bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of vitamin D replacement therapy on serum FGF23 concentrations in vitamin D-deficient women in short term
Authors: Kubat Uzum Ayse , Salman Serpil , Telci Aysegul , Boztepe Harika , Tanakol Refik , Alagol Faruk , Colak Ozbey Nese 
Published: August 2010

ObjectiveFibroblast growth factor 23 (FGF23), a phosphatonin, inhibits renal phosphate reabsorption and suppresses 1-α hydroxylase activity. Calcitriol stimulates FGF23 synthesis in bone. We aimed to determine the effect of vitamin D replacement therapy on serum FGF23 concentrations in vitamin D-deficient women and to compare the FGF23 concentrations of vitamin D-deficient patients with healthy subjects and patients with genetically determined hypophosphatemic rachitis.Design and methodsThe study group was composed of vitamin D-deficient females (n=18, mean age 29.1±9.9 years), vitamin D-sufficient healthy females (control group;n=19, mean age 28.5±5.2 years), and patients with genetically determined hypophosphatemic rachitis (n=13, mean age 26.5±15.1 years). The groups were compared for serum FGF23, 1,25-dihydroxyvitamin D3 (1,25(OH)2D), calcium, phosphate, bone turnover markers, intact parathyroid hormone (PTH), and urinary excretion of calcium and phosphate. The vitamin D-deficient group was re-evaluated after a standard treatment regimen.ResultsSerum FGF23 concentrations were significantly lower in vitamin D-deficient patients than in vitamin D-sufficient women and hypophosphatemic rachitis group. Serum FGF23 and phosphate concentrations further decreased significantly during replacement of vitamin D (P<0.05). A significant negative correlation was evident between FGF23 and PTH before vitamin D replacement in the patients (r=−0.469,P<0.05).ConclusionDecreased FGF23 concentrations, which further decline during vitamin D replacement therapy, may have favorable action on bone mineralization by counterregulatory effect on phosphate homeostasis. Lower 1,25(OH)2D concentrations at baseline and hypophosphatemia during treatment may have dominating effects on FGF23 concentrations in vitamin D deficiency, leading to decreased FGF23 concentrations at baseline and during replacement therapy.
Media Literacy Education for Elementary School Substance Use Prevention: Study of Media Detective
Authors: Kupersmidt Janis B. , Scull Tracy M. , Austin Erica Weintraub 
Published: August 2010

OBJECTIVES:
Media Detective is a 10-lesson elementary school substance use prevention program developed on the basis of the message interpretation processing model designed to increase children's critical thinking skills about media messages and reduce intent to use tobacco and alcohol products. The purpose of this study was to conduct a short-term, randomized, controlled trial to evaluate the effectiveness of Media Detective for achieving these goals.

METHODS:
Elementary schools were randomly assigned to conditions to either receive the Media Detective program (n = 344) or serve in a waiting list control group (n = 335).

RESULTS:
Boys in the Media Detective group reported significantly less interest in alcohol-branded merchandise than boys in the control group. Also, students who were in the Media Detective group and had used alcohol or tobacco in the past reported significantly less intention to use and more self-efficacy to refuse substances than students who were in the control group and had previously used alcohol or tobacco.

CONCLUSIONS:
This evaluation provides evidence that Media Detective can be effective for substance use prevention in elementary school–aged children. Notably, media-related cognitions about alcohol and tobacco products are malleable and relevant to the development and maintenance of substance use behaviors during late childhood. The findings from this study suggest that media literacy–based interventions may serve as both a universal and a targeted prevention program that has potential for assisting elementary school children in making healthier, more informed decisions about use of alcohol and tobacco products.
Pentavalent Rotavirus Vaccine and Prevention of Gastroenteritis Hospitalizations in Australia
Authors: Field Emma J. , Vally Hassan , Grimwood Keith , Lambert Stephen B. 
Published: August 2010

OBJECTIVE:
A publicly funded, universal infant pentavalent rotavirus vaccine (RV5) program was implemented in Queensland, Australia, in mid-2007. We sought to assess vaccine effectiveness (VE) of 3 doses of RV5 at preventing rotavirus and nonrotavirus acute gastroenteritis (AGE) hospitalizations in the first birth cohort and impact on hospitalizations in all age groups.

METHODS:
Hospitalization rates for rotavirus and nonrotavirus AGE in all age groups before and after RV5 introduction were compared. Population vaccine coverage, hospitalization data, and individual vaccination status were obtained from routinely collected, publicly funded state- and nationally based data sets. Data linkage was performed to calculate 3-dose VE for preventing hospitalization in the eligible age group.

RESULTS:
RV5 coverage in the first eligible birth cohort was 89.6% for at least 1 dose and 73.1% for 3 doses. Three-dose VE for preventing nonrotavirus AGE hospitalization was 62.3% to 63.9% (any/primary diagnosis) and 89.3% to 93.9% (any/primary diagnosis) for rotavirus hospitalizations. After program implementation, there were immediate and sustained reductions in rotavirus hospitalizations for those who were younger than 20 years and nonrotavirus AGE-coded hospitalizations for those who were younger than 5 years.

CONCLUSIONS:
RV5 is highly effective at preventing rotavirus hospitalizations in a developed country setting, confirming efficacy figures from the pivotal clinical trial. Additional direct and indirect effects are substantial and include reductions in nonrotavirus AGE hospitalizations in vaccinated age groups and rotavirus and nonrotavirus AGE hospitalization rates in older age groups.
Expression of human growth hormone gene in Pleurotus eryngii
Authors: Kim Seung , Sapkota Kumar , Choi Bong-Suk , Kim Sung-Jun 
Published: August 2010

Abstract
Recombinant human growth hormone (rhGH) has been widely used in many medical applications. Large scale production of rhGH is important for a wider application of this molecule in the field of proteomics. This investigation reports a modified Agrobacterium-mediated method for transfer and expression of human growth hormone gene in the popular edible mushroom Pleurotus eryngii. A binary vector pCAMBIA1304 containing the hGH2 gene was constructed and introduced into Pleurotus eryngii via Agrobacterium tumefaciens-mediated transformation. Integration of hGH2 into mushroom genome was detected by PCR and expression was confirmed by Western blot assay. The successful expression of the human growth hormone gene in mushroom suggests that the proposed modified transformation system is probably useful for the production of transgenic mushrooms.
Using Talking Mats to support communication in persons with Huntington's Disease
Authors: Ferm Ulrika , Sahlin Anna , Sundin Linda , Hartelius Lena 
Published: August 2010

Background: Many individuals with Huntington's disease experience reduced functioning in cognition, language and communication. Talking Mats is a visually based low technological augmentative communication framework that supports communication in people with different cognitive and communicative disabilities.Aims: To evaluate Talking Mats as a communication tool for people in the later stages of Huntington's disease.Methods & Procedures: Five individuals with Huntington's disease participated in the study. Three conditions were compared: unstructured communication, verbally structured communication, and communication using Talking Mats. The conversations were videotaped and analysed quantitatively and qualitatively.Outcomes & Results: Talking Mats increased communicative effectiveness for all participants. Verbally structured conversation resulted in higher effectiveness than the unstructured counterpart and effectiveness differed depending on the type of conversational topic.Conclusions & Implications: Talking Mats could be a valuable resource for people with Huntington's disease and their conversation partners. It could be used for social purposes, for understanding a person's opinions and for making decisions. Additional research is necessary in order to generalize the results to the population of individuals with Huntington's disease and to understand better the mechanisms behind the positive effects observed.
Children’s fracture: an experience from a zonal hospital in Nepal
Authors: Paudel KP , Thapa SK 
Published: August 2010

A retrospective study of all paediatric fractures presenting to Bharatpur hospital in two years was undertaken. The aim of this study is to find out incidence of fractures in children attending Bharatpur Hospital, their risk factors, problem magnitude and problem areas, preventability, disease burden socio-economically, so that it will be helpful in formulations of plans and policies at national or regional level to prevent or to decrease the injury incidences among children in populations in Nepal. Details are collected from children with fractures attending Bharatpur hospital in emergency, outdoor and indoors including their variables, geographical distribution, injury mechanism and pattern, time of seeking treatment and places etc. the study period is from January 2008 to December 2009. 1216 children were treated ranging in age from 0 to 14 year. 35% of cases were from Chitwan district. Incidence of fracture increases with age. Left sided limbs had more fractures as they assume the role of protection. 67% of children's fractures occurred in males. The majority of fractures in children involve the upper limb i.e. 80%. Supracondylar fractures of humerus predominate all incidences. Mode of injury in majority of the cases was fall. Key words: Children; fractures; humerus DOI: 10.3126/jcmsn.v6i2.3611 Journal of college of Medical Sciences-Nepal, 2010, Vol.6, No-2, 14-17
Prevalence of hyperuricemia in Chitwan District of Nepal
Authors: Kumar S , Singh AR , Takhelmayum R , Shrestha P , Sinha JN 
Published: August 2010

The prevalence of hyperuricemia has been increasing in both developed and developing countries. The purpose of present study was to know the prevalence of hyperuricemia in the population of Chitwan district as well as to compare the prevalence of hyperuricemia between Mongolian and non-Mongolian races of Chitwan district, who had attended the College of Medical Sciences and Teaching Hospital, Bharatpur, Nepal during the period of January 1999 to December 2003. In this study 3794 subjects were investigated for serum uric acid level (SUA). Hyperuricemia is defined as SUA more than 7mg/dl for males and menopausal women and 6mg/dl for pre-menopausal females. SUA was estimated by Caraway method in digital colorimeter. Overall prevalence was 21.42%; the condition was more common in men than women (26.78% vs. 16.82%; p<0.001). The prevalence was higher in Mongolian than non Mongolian both in males and females (24.50 % Vs 21.06%; p>0.05). Key words: Hyperuricemia; SUA; digital colorimeter DOI: 10.3126/jcmsn.v6i2.3612 Journal of college of Medical Sciences-Nepal, 2010, Vol.6, No-2, 18-23
Evolutionary and ecophysiological significance of sugar utilization by the peat moss Sphagnum compactum (Sphagnaceae) and the common charophycean associates Cylindrocystis brebissonii and Mougeotia sp. (Zygnemataceae)
Authors: Graham Linda E. , Kim Eunsoo , Arancibia‐Avila Patricia , Graham James M. , Wilcox Lee W. 
Published: August 2010

• Premise of the study: The goal of this study was to illuminate the evolutionary history and ecological importance of plant mixotrophy—the uptake and utilization of exogenous organic compounds.• Methods: We quantitatively assessed the effect of sugar amendments on laboratory growth of Sphagnum compactum as a representative emergent peat moss and two species of ecologically associated zygnematalean algae, Cylindrocystis brebissonii and Mougeotia sp.• Key results: Together with observations published elsewhere, our results suggest that under carbon or light limitation, the uptake of exogenous sugars by cells of charophycean algae and peat mosses may help these organisms maintain positive carbon balance. Utilization of 1% glucose by aquatic‐grown algae helped to relieve dissolved inorganic carbon limitation, enhancing photoautotrophic growth by factors of 9.0 and 1.7, respectively. After an 8‐wk growth period, amendments of 1% and 2% glucose enhanced air‐grown moss biomass by 28 and 39 times, respectively, that of controls lacking sugar amendments. After 9 wk, 1% fructose enhanced biomass by 21 times, and 2% sucrose enhanced biomass by 31 times.• Conclusion: Our results indicate that plant mixotrophy is an early‐evolved trait. The results also indicate that quantitative differences in sugar utilization by bryophytes and charophycean algae correlate with relative investments in protective cell‐wall polyphenolics measured in previous studies, suggesting that sugar utilization may subsidize the cost of producing phenolic wall compounds in bryophytes.
Children as Bellwethers of Recovery: Dysfunctional Systems and the Effects of Parents, Households, and Neighborhoods on Serious Emotional Disturbance in Children After Hurricane Katrina
Authors: Abramson David M. , Park Yoon Soo , Stehling-Ariza Tasha , Redlener Irwin 
Published: August 2010

ABSTRACTBackground:Over 160 000 children were displaced from their homes after Hurricane Katrina. Tens of thousands of these children experienced the ongoing chaos and uncertainty of displacement and transiency, as well as significant social disruptions in their lives. The objectives of this study were to estimate the long-term mental health effects of such exposure among children, and to elucidate the systemic pathways through which the disaster effect operates.Methods:The prevalence of serious emotional disturbance was assessed among 283 school-aged children in Louisiana and Mississippi. These children are part of the Gulf Coast Child & Family Health Study, involving a longitudinal cohort of 1079 randomly sampled households in the two states, encompassing a total of 427 children, who have been interviewed in 4 annual waves of data collection since January 2006. The majority of data for this analysis was drawn from the fourth round of data.Results:Although access to medical care for children has expanded considerably since 2005 in the region affected by Hurricane Katrina, more than 37% of children have received a clinical mental health diagnosis of depression, anxiety, or behavior disorder, according to parent reports. Children exposed to Hurricane Katrina were nearly 5 times as likely as a pre-Katrina cohort to exhibit serious emotional disturbance. Path analyses confirm the roles played by neighborhood social disorder, household stressors, and parental limitations on children's emotional and behavioral functioning.Conclusions:Children and youth are particularly vulnerable to the effects of disasters. They have limited capacity to independently mobilize resources to help them adapt to stressful postdisaster circumstances, and are instead dependent upon others to make choices that will influence their household, neighborhood, school, and larger social environment. Children's mental health recovery in a postdisaster setting can serve as a bellwether indicator of successful recovery or as a lagging indicator of system dysfunction and failed recovery.(Disaster Med Public Health Preparedness. 2010;4:S17-S27)
Evaluation of toxicity and antitumor activity of cycloviolacin O2 in mice
Authors: Burman Robert , Svedlund Erika , Felth Jenny , Hassan Saadia , Herrmann Anders , Clark Richard J. , Craik David J. , Bohlin Lars , Claeson Per , Göransson Ulf , Gullbo Joachim 
Published: August 2010

AbstractCycloviolacin O2 is a small cyclic cysteine‐rich protein belonging to the group of plant proteins called cyclotides. This cyclotide has been previously shown to exert cytotoxic activity against a variety of human tumor cell lines as well as primary cultures of human tumor cells in vitro. This study is the first evaluation of its tolerability and antitumor activity in vivo. Maximal‐tolerated doses were estimated to 1.5 mg/kg for single intravenous (i.v.) dosing and 0.5 mg/kg for daily repeated dosing, respectively. Two different in vivo methods were used: the hollow fiber method with single dosing (i.v. 1.0 mg/kg) and traditional xenografts with repeated dosing over 2 weeks (i.v. 0.5 mg/kg daily, 5 days a week). The human tumor cell lines used displayed dose‐dependent in vitro sensitivity (including growth in hollow fibers to confirm passage of cycloviolacin O2 through the polyvinylidene fluoride fibers), with IC50 values in the micromolar range. Despite this sensitivity in vitro, no significant antitumor effects were detected in vivo, neither with single dosing in the hollow fiber method nor with repeated dosing in xenografts. In summary, the results indicate that antitumor effects are minor or absent at tolerable (sublethal) doses, and cycloviolacin O2 has a very abrupt in vivo toxicity profile, with lethality after single injection at 2 mg/kg, but no signs of discomfort to the animals at 1.5 mg/kg. Repeated dosing of 1 mg/kg gave a local‐inflammatory reaction at the site of injection after 2–3 days; lower doses were without complications. © 2010 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 94: 626–634, 2010.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Analysis and classification of circular proteins in CyBase
Authors: Kaas Quentin , Craik David J. 
Published: August 2010

AbstractCyBase is a database dedicated to the study of the sequences and three‐dimensional structures of ribosomally synthesized, backbone cyclized proteins, and their synthetic variants. This article describes CyBase data and tools that are useful in the analysis of circular proteins. Circular proteins have now been discovered in organisms from all kingdoms of life, and given the current rate of discovery they could soon number in the thousands. Presently CyBase manages 427 protein sequences, 106 nucleic acid sequences, and 49 protein three‐dimensional structures from 44 different species. Circular proteins are grouped into distinct classes according to their origin and sequence similarities. These classes include trypsin inhibitors, bacterial proteins, mushroom toxins, cyclotides, and cyclic defensins from primates. Several protein classification types are used in CyBase to designate proteins extracted from natural resources (wild type and precursor) or engineered (modified wild type, grafted, mutant, cyclic permutant, and acyclic permutant). CyBase has tools for the analysis of mass spectrum fingerprints of cyclic peptides, and assists in the discovery of new circular proteins. Some of the developments detailed here have been made specifically for the largest class of circular proteins, thecyclotides, but could be adapted for other classes of cyclic proteins. The cyclotide‐specific tools include two‐dimensional representations of domains and alternative displays of alignments for precursor sequences. This alignment prompted us to propose a revision of the cyclotide precursor organization, in which the repeated regions now include a small C‐terminal region, which appears to have a significant role in the biosynthesis of mature cyclotides. © 2010 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 94: 584–591, 2010.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
ChemInform Abstract: Synthesis and Structure of Cs3Ti3As5O20.
Authors: LII K.‐H. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Structure of SrPdH2.7.
Authors: BRONGER W. , RIDDER G. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Mixed Valence Oxovanadate: La11V(IV)V(V)3O26.
Authors: MUELLER‐BUSCHBAUM HK. , WERNER J.‐P. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Single Crystal X‐Ray Structure Analysis and Magnetic Properties of Ba3YRu2O9, Ba3GdRu2O9, and Ba3YbRu2O9.
Authors: RATH M. , MUELLER‐BUSCHBAUM HK. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Crystal Structures of VSn2, NbSn2 and CrSn2 with Mg2Cu‐Type Structure and NbSnSb with CuAl2‐Type Structure.
Authors: WOELPL T. , JEITSCHKO W. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: LiMg2RuH7, a New Quaternary Metal Hydride Containing Octahedral (Ru(II) H6)4‐ Complex Anions.
Authors: HUANG B. , YVON K. , FISCHER P. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Crystal Structure of KCr0.8Al0.2Mo2O8.
Authors: SEDELLO O. , MUELLER‐BUSCHBAUM HK. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Luminescence and Energy Migration in the Oxyapatite Ca2Gd8(SiO4)6O2 Doped with Several Rare Earth and Mercury‐Like Ions.
Authors: LIN J. , SU Q. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.