bluuebunny/crossref_metadata_2025_split huggingface dataset:
Membangun Literasi Baca Tulis: Mengeksplorasi Strategi Holistik dan Konstruktivis melalui ZPD dalam Pendidikan Anak Usia Dini
Authors: Nurhayati Yuliana , - Wahyu , - Novitawati 
Published: June 2024

Tujuan penelitian adalah mendeskripsikan strategi pembelajaran literasi baca tulis anak usia 4-5 tahun serta fasilitas pendukung pembelajaran dan bentuk kolaborasi guru dan orang tua siswa. Penelitian ini dilakukan di PAUD Terpadu Islam Sabilal Muhtadin dan PAUD Terpadu Islam Baitul Makmur Kota Banjarmasin. Penelitian ini menggunakan pendekatan kualitatif dengan metode multi situs. Teknik pengumpulan data menggunakan observasi, wawancara, dan dokumentasi. Analisis data tunggal dan data lintas situs dilakukan melalui kondensi data, penyajian data, dan verifikasi data. Teknik untuk menguji keabsahan data melalui perpanjangan pengamatan, meningkatkan ketekunan, penggunaan bahan referensi dan trianggulasi data, member scheck data dan analisis kasus. Hasil penelitian menunjukan bahwa : (1) strategi penekanan pembelajaran aktif dan interaksi sosial dalam pengembangan pengetahuan anak melalui ragam main dan media seperti musik, kartu bergambar, storytelling, dan media elektronik, dapat menciptakan lingkungan stimulatif. Pendekatan holistik dan pembelajaran konstruktivis dalam literasi baca tulis anak usia dini memberikan kontribusi positif terhadap perkembangan literasi anak usia dini; (2) keseluruhan fasilitas pendukung yang lengkap dapat menciptakan ekosistem pembelajaran holistik, melibatkan semua pihak terkait dalam mendukung perkembangan anak-anak usia dini; (3) kesadaran tinggi, komunikasi aktif, dan pertemuan dari kedua belah pihak terhadap kebutuhan anak-anak dalam mendukung kegiatan literasi di rumah dan di sekolah sangat di utamakan untuk mencapai kemampuan potensi anak secara optimal.
Single-cell and Bulk Transcriptomic Analyses Reveal a Stemness and Circadian Rhythm Disturbance-related Signature Predicting Clinical Outcome and Immunotherapy Response in Hepatocellular Carcinoma
Authors: Zhu Xiaojing , Zhang Zixin , Zhang Jiaxing , Xiao Yanqi , Wang Hao , Wang Mingwei , Jiang Minghui , Xu Yan 
Published: June 2024

Aims:
Investigating the impact of stemness-related circadian rhythm disruption
(SCRD) on hepatocellular carcinoma (HCC) prognosis and its potential as a predictor for immunotherapy
response.

Background:
Circadian disruption has been linked to tumor progression through its effect on the
stemness of cancer cells.

Objective:
Develop a novel signature for SCRD to accurately predict clinical outcomes and immune
therapy response in patients with HCC.

Methods:
The stemness degree of patients with HCC was assessed based on the stemness index
(mRNAsi). The co-expression circadian genes significantly correlated with mRNAsi were identified
and defined as stemness- and circadian-related genes (SCRGs). The SCRD scores of samples
and cells were calculated based on the SCRGs. Differentially expressed genes with a prognostic
value between distinct SCRD groups were identified in bulk and single-cell datasets to develop an
SCRD signature.

Results:
A higher SCRD score indicates a worse patient survival rate. Analysis of the tumor microenvironment
revealed a significant correlation between SCRD and infiltrating immune cells.
Heterogeneous expression patterns, functional states, genomic variants, and cell-cell interactions
between two SCRD populations were revealed by transcriptomic, genomic, and interaction analyses.
The robust SCRD signature for predicting immunotherapy response and prognosis in patients
with HCC was developed and validated in multiple independent cohorts.

Conclusions:
In summary, distinct tumor immune microenvironment patterns were confirmed under
SCRD in bulk and single-cell transcriptomic, and SCRD signature associated with clinical outcomes
and immunotherapy response was developed and validated in HCC.
Characterization and In vivo Evaluation of Polymorphic Valnemulin Hydrogen Fumarate
Authors: Xinle Zhu , Li Zhang , Jian Li , Hui Zhao , Jinhua Gu , Hejia Wang 
Published: June 2024

Aims:
In the present study, a valnemulin hydrogen fumarate prodrug was characterized,
its stability was compared with valnemulin hydrochloride, and the efficacy was evaluated in Actinobacillus
pleuropneumoniae-induced pneumonia in mice.

Method:
Optical microscopy, X-ray powder diffraction, infrared spectroscopy, and hydrogen nuclear
magnetic resonance spectroscopy were used to study the physical and chemical properties of
the prodrug. The thermal stability was investigated in comparison with valnemulin hydrochloride
to improve the preparation process of valnemulin hydrogen fumarate soluble powder and maximize
its drug effect. Additionally, the efficacy of valnemulin hydrogen fumarate was evaluated in
a challenge-treatment trial in mice using an in vitro antimicrobial susceptibility test.

Results:
The valnemulin hydrogen fumarate had high crystallinity. After light irradiation for 20
days, valnemulin hydrogen fumarate did not degrade, whereas valnemulin hydrochloride did. These
results showed that the valnemulin hydrogen fumarate was stable. At the same dose in drinking
water, the valnemulin hydrogen fumarate was more effective than the reference drug (tiamulin
fumarate) in an Actinobacillus pleuropneumoniae challenge-treatment trial.

Conclusion:
Valnemulin hydrogen fumarate shows excellent potential for application as a veterinary
drug.
Current Aspects of Nanotechnology Based Healing Approaches for
Diabetic Wounds
Authors: Rautela Deepraj Singh , Das Saumya , Mazumder Avijit , Sharma Bhawana , Mishra Rashmi , Singh Gurvinder 
Published: June 2024

Abstract:
Diabetic wounds represent a significant clinical challenge due to their chronic nature,
slow healing rates, and susceptibility to infections, often leading to severe complications. Nanotechnology
plays a transforming role in advancing diabetic wound repair therapies. The field of
nanotechnology has shown great promise in the medical field in recent years, offering precise
tools and materials at the nanoscale to address the complexities of diabetic wound management.
The latest breakthroughs in nanomaterial design and fabrication showcase nanoparticles, nanofibers,
and hydrogels tailored to enhance tissue regeneration, promote angiogenesis, and modulate
the wound microenvironment. These engineered materials serve as versatile systems for the regulated
release of cytokines and antimicrobial agents, offering a multifaceted approach to diabetic
wound healing. Nanotechnology enables the growth of smart medication delivery technologies
with accurate targeting and sustained delivery of medicinal substances right to the location of the
wound. Prolonged injuries in hyperglycemic patients are particularly prone to infections, leading
to prolonged healing times and increased morbidity. Some of the nanoscale antimicrobial agents,
such as nanozyme-chitosan-derived hydrogel, silver nanoparticles, and antimicrobial peptides that
exhibit potent bactericidal properties, reduce the risk of infections and associated complications.
Nanosensors and advanced imaging techniques enable real-time monitoring of wound healing
progress. These tools provide clinicians with valuable insights into tissue viability, inflammation
levels, and treatment efficacy, facilitating timely adjustments to therapeutic regimens. This is an
inclusive overview of the current state of nanotechnology for the treatment of diabetic wounds, offering
insights into the promise and challenges of this innovative approach, by harnessing the
unique properties of nanoscale materials and technologies.
E-learning, assessment competency and academic performance: A structural equation modelling approach
Authors: Chemdghazali Nor Hasnida , Suppian Zahari , Ahmad Hishamuddin , Zaini Syaza Hazwani , Shuib Tajul Rosli 
Published: June 2024

E-learning practices and the competency in assessing should facilitate ones’ academic performance. The main purpose of this study is to explore the degree of influence of e-learning practices and competency in assessment on academic achievement of students. This study is a quantitative approach using survey method involving the process of data collection through the administration of constructed instruments. The population of the study involves student teachers from the three selected universities in Selangor and Perak. Sample selection is made using random sampling technique. 460 student teachers are selected. The questionnaire for e-learning practices is adapted from OLES (Renee, 2011) and for the competency in assessment comes from Zahari (2018). The structural equation modelling (SEM) analysis is used to test the hypothesized relationship. The results show that, e-learning practices, knowledge and skills in assessing and attitude in assessment significantly influence academic achievement of students. E-learning practices has a highest value and a significant standardized regression coefficient with students’ achievement (0.39) followed by skills in assessment (0.27), knowledge in assessment (0.09) and lastly is attitude in assessment (0.08). The core findings of the study have few implications for higher education and practice, measurement and theory development, and future research.
Investigation of Public Acceptance of Misinformation Correction in Social Media Based on Sentiment Attributions: Infodemiology Study Using Aspect-Based Sentiment Analysis
Authors: Ma Ning , Yu Guang , Jin Xin 
Published: June 2024

Background
The proliferation of misinformation on social media is a significant concern due to its frequent occurrence and subsequent adverse social consequences. Effective interventions for and corrections of misinformation have become a focal point of scholarly inquiry. However, exploration of the underlying causes that affect the public acceptance of misinformation correction is still important and not yet sufficient.

Objective
This study aims to identify the critical attributions that influence public acceptance of misinformation correction by using attribution analysis of aspects of public sentiment, as well as investigate the differences and similarities in public sentiment attributions in different types of misinformation correction.

Methods
A theoretical framework was developed for analysis based on attribution theory, and public sentiment attributions were divided into 6 aspects and 11 dimensions. The correction posts for the 31 screened misinformation events comprised 33,422 Weibo posts, and the corresponding Weibo comments amounted to 370,218. A pretraining model was used to assess public acceptance of misinformation correction from these comments, and the aspect-based sentiment analysis method was used to identify the attributions of public sentiment response. Ultimately, this study revealed the causality between public sentiment attributions and public acceptance of misinformation correction through logistic regression analysis.

Results
The findings were as follows: First, public sentiments attributed to external attribution had a greater impact on public acceptance than those attributed to internal attribution. The public associated different aspects with correction depending on the type of misinformation. The accuracy of the correction and the entity responsible for carrying it out had a significant impact on public acceptance of misinformation correction. Second, negative sentiments toward the media significantly increased, and public trust in the media significantly decreased. The collapse of media credibility had a detrimental effect on the actual effectiveness of misinformation correction. Third, there was a significant difference in public attitudes toward the official government and local governments. Public negative sentiments toward local governments were more pronounced.

Conclusions
Our findings imply that public acceptance of misinformation correction requires flexible communication tailored to public sentiment attribution. The media need to rebuild their image and regain public trust. Moreover, the government plays a central role in public acceptance of misinformation correction. Some local governments need to repair trust with the public. Overall, this study offered insights into practical experience and a theoretical foundation for controlling various types of misinformation based on attribution analysis of public sentiment.
Artificial Intelligence in Dental Education: Opportunities and Challenges of Large Language Models and Multimodal Foundation Models
Authors: Claman Daniel , Sezgin Emre 
Published: June 2024

Abstract
Instructional and clinical technologies have been transforming dental education. With the emergence of artificial intelligence (AI), the opportunities of using AI in education has increased. With the recent advancement of generative AI, large language models (LLMs) and foundation models gained attention with their capabilities in natural language understanding and generation as well as combining multiple types of data, such as text, images, and audio. A common example has been ChatGPT, which is based on a powerful LLM—the GPT model. This paper discusses the potential benefits and challenges of incorporating LLMs in dental education, focusing on periodontal charting with a use case to outline capabilities of LLMs. LLMs can provide personalized feedback, generate case scenarios, and create educational content to contribute to the quality of dental education. However, challenges, limitations, and risks exist, including bias and inaccuracy in the content created, privacy and security concerns, and the risk of overreliance. With guidance and oversight, and by effectively and ethically integrating LLMs, dental education can incorporate engaging and personalized learning experiences for students toward readiness for real-life clinical practice.
Implementasi teori the seven pillars of information literacy sconul dalam menganalisis kemampuan literasi informasi masyarakat Kelurahan Pattallassang
Authors: Lukman Lukman , Hamna Dian Muhtadiah , Azzahra A Nurul Fatimah 
Published: June 2024

Introduction. Information literacy is one of the keys to improve the quality of human resources. This study aims to determine the level of information literacy of the Pattallassang Village community and obtain solutions to optimize problems related to information literacy in the community.
Data Collection Methods. We collected the data using a quantitative descriptive approach. The data collection technique was carried out by distributing questionnaires. There were 80 respondents participated as a result of an accidental sampling.
Data Analysis. The research variable used was information literacy skills with indicators of the seven pillars of information literacy theory by the Standing Conference of National and University Libraries. The data analysis technique was descriptive resulted by the Likert scale.
Results and Discussion. Referring to the seven pillars of information literacy, the average score of Pattallassang Village community information literacy level showed a moderate category. Solutions to optimize the problem, namely community education, is recommended to the government to form community information groups by providing anti-hoax information media platforms.
Conclusion and Suggestion. Implementing information literacy in life is very important in the current era. Research related to information literacy in society needs to be carried out by providing education to support sustainability.
Upaya guru memanfaatkan perpustakaan sekolah sebagai sumber belajar di Sekolah Dasar Negeri Tosanan Ponorogo
Authors: Riyanto Riyanto , Tajab Muh. , Rifan Moh. , Wuryono Wuryono , Nursiah Nursiah , Setyaningrum Krista Alifa , Ridhwan M. Habib Izazur 
Published: June 2024

Introduction. The aim of the paper is to understand the efforts of Islamic education teachers in utilizing the library as one of the school's facilities and infrastructure, at State Elementary School of Tosanan Ponorogo by using the approach of the Association for Education Communication Technology (AECT).
Data Collection Methods. This was a qualitative descriptive with by observations and, structured interviews.
Data Analysis. The interview data was transcribed for analysis.
Results and Discussion. The efforts showing by teacher’s to utilize the school library as a learning resource are shown by improving their quality. These Include how to absorb information from the library as teaching, to increase the intensity of visits to the library, to increase the collection/number of books and to make the best use of the existing library facilities.
Conclusions and Recommendations. The library at State Elementary School of Tosanan Ponorogo has not been maximally utilized as a learning resource in every lesson. This library should increase the number of books, support facilities for users and manage library base on standards. For further research it is hoped that it can be expanded, so that it is not limited to Islamic religious education teachers but to teachers of other subjects.
Peran GLAM dalam pendidikan tinggi untuk pelestarian budaya
Authors: Istiarni Atin , Widayati Jamzanah Wahyu 
Published: June 2024

Introduction: This research aims to explore the factors influencing the implementation of GLAM in academic libraries considering technological, organizational and environmental factors.
Method: We used a quantitative approach with Structural Equation Modelling. 91 university librarians in Indonesia responded to the distributed questionnaires.
Data analysis: The data was analysed using Exploratory Factor Analysis.
Results: The most influential factor is technology at 31.31%, obtained from observations to 14 variables. The second influencing factor is organization with a calculation result of 27.10% obtained from the 10 observed variables. The third influencing factor is environment, with a calculation result of 17.3% based on 3 observed variables. The innovation diffusion in the implementation of GLAM in university libraries as an effort to preserve culture however is not yet ready from a technological and organizational perspective. It is noted that environment is the factor with the least influence.
Conclusion: This research uses three factors, namely technology, organization and environment as a theoretical basis for answering problems. Based on the research results, technology is the most influential dominant factor in implementing the GLAM in university libraries. Organization is the second influencing factor, while environment is the third factor.
Nanodispersion of TiO2 in hypochlorous acid and its antimicrobial effect against oral pathogens
Authors: Morales-Noriega Juan Rafael , López-Ayuso Christian Andrea , Acosta-Torres Laura Susana , Manisekaran Ravichandran 
Published: June 2024

The continuous and inappropriate use of traditionally used antimicrobial agents has caused the rise of multidrug-resistant (MDR) bacterial strains and the mutation of microorganisms in the field of dentistry. Therefore, various nanoparticles have been developed to combat resistant pathogens. Titanium dioxide (TiO2) nanoparticles have been attractive antimicrobial agents because of their chemical stability, non-toxicity, and inexpensive precursors. Therefore, TiO2-based nanodispersions were explored by preparing them with well-known antimicrobial agents, such as hypochlorous acid (HOCl), to enhance the antimicrobial effect. In this study, sol-gel-based TiO2 NPs-HOCl nanodispersions were synthesized and characterized. The antimicrobial effect was assessed by a microdilution assay using S. mutans, S. aureus, E. faecalis, and C. albicans strains by incubating different concentrations of the nanodispersions. To evaluate the cytotoxic effects, stem cells from the apical papilla (SCAPs) were inoculated and evaluated using the MTT assay. The nanodispersion exhibited an enhanced antimicrobial effect, with almost no cytotoxicity. The HOCl-based nanodispersion exhibited a greater antimicrobial effect and high stability. Thus, it can be used as a promising antimicrobial agent for the treatment of various dental pathogens.
Dasar Pertimbangan Hakim Dalam Memberikan Putusan Lepas (Onslag) Terhadap Pelaku Tindak Pidana Korupsi
Authors: Sulistiani Sulistiani , Hafrida Hafrida , Monita Yulia 
Published: June 2024

The purpose of this study was to find out and analyze the basic considerations of judges in passing decisions to release all lawsuits against perpetrators of corruption in Decision Number 4/PID.TPK/2022/PT.MTR. The problem of this research is what is the basis for the judge's considerations in passing the decision to release all lawsuits in Decision Number 4/PID.TPK/2022/PT.MTR against the defendant Aryanto Prametu. The normative juridical research method uses several approaches, namely, statutory approach (statute approach), case approach (case approach), and conceptual approach (conceptual approach). The legal materials used are primary legal materials, secondary legal materials, and tertiary legal materials. The results of the study show that the judge's consideration in passing the decision to release all lawsuits against the defendant Aryanto Prametu in Decision Number 4/PID.TPK/2022/PT.MTR is due to the reasons for abolishing the crime in the form of justification reasons. As for what he considered, namely that the defendant had fulfilled the procurement interests even though the work was late from the contract period and with different varieties but the quality and price were not much different, there was no loss to state finances because the defendant had paid in full, and the defendant did not get any profit at all. So the defendant's actions have fulfilled the aims and objectives of Supreme Court Jurisprudence No. 42K/KR/1966 dated 08 January 1966.
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Tujuan penelitian ini adalah untuk menganalisis dasar pertimbangan hakim dalam menjatuhkan putusan lepas dari segala tuntutan hukum terhadap pelaku tindak pidana korupsi pada Putusan Nomor 4/PID.TPK/2022/PT.MTR. Permasalahan dari penelitian ini adalah apakah dasar pertimbangan hakim dalam menjatuhkan putusan lepas dari segala tuntutan hukum pada Putusan Nomor 4/PID.TPK/2022/PT.MTR terhadap terdakwa Aryanto Prametu. Metode penelitian yuridis normatif dengan menggunakan beberapa pendekatan yaitu, pendekatan perundang-undangan (statute approach), pendekatan kasus (case approach), dan pendekatan konseptual (conceptual approach). Bahan hukum yang digunakan adalah bahan hukum primer, bahan hukum sekunder, dan bahan hukum tersier. Hasil penelitian menunjukkan bahwa yang menjadi pertimbangan hakim dalam menjatuhkan putusan lepas dari segala tuntutan hukum terhadap terdakwa Aryanto Prametu pada Putusan Nomor 4/PID.TPK/2022/PT.MTR dikarenakan adanya alasan penghapus pidana yang berupa alasan pembenar. Adapun yang menjadi pertimbangannya yaitu bahwa terdakwa telah memenuhi kepentingan pengadaan walaupun pengerjaannya terlambat dari masa kontrak dan dengan varietas yang berbeda tetapi kualitas dan harganya tidak jauh berbeda, tidak ada kerugian keuangan negara dikarenakan telah dibayar lunas oleh terdakwa, dan terdakwa tidak mendapatkan untung sama sekali. Maka perbuatan terdakwa telah memenuhi maksud dan tujuan Yurisprudensi Mahkamah Agung No. 42K/KR/1966 tanggal 08 Januari 1966.