bluuebunny/crossref_metadata_2025_split huggingface dataset:
The treatment of sinusitis following maxillary sinus grafting with the association of functional endoscopic sinus surgery (FESS) and an intra‐oral approach
Authors: Chiapasco M. , Felisati G. , Zaniboni M. , Pipolo C. , Borloni R. , Lozza P. 
Published: March 2012

AbstractAim of the studyTo present the results of a prospective study on the management of infectious complications following maxillary sinus floor elevation procedures with a combined endoscopic (FESS) and intra‐oral approach.Materials and methodsFrom 2005 to 2009, twenty consecutive patients were diagnosed for sinusal chronic infectious complications refractory to medical treatment following maxillary sinus floor elevation and grafting procedures. All patients were treated with a combination of functional endoscopic sinus surgery (FESS) through a transnasal approach and an intra‐oral approach, performed by an ear, nose, and throat team and an oral and maxillofacial team, respectively, in the same surgical session under general anesthesia.ResultsIn 16 of 20 patients, the 4‐week endoscopic control demonstrated a complete clinical healing and recovery of the normal sinus ventilation and drainage. In two patients, the persisting sinusitis at the 4‐week control was successfully treated (8th week) with an antibiotic therapy based on the antibiogram carried out on the bacterial culture obtained by the aspiration of the sinusal content. In one patient, the persisting sinusitis (3 months after surgery) was successfully treated with the aspiration of the infectious material from the maxillary sinus. In one patient, finally, it was necessary to perform a second combined surgical treatment to treat the persisting sinusitis.Discussion and conclusionsIn this study, a relevant number of cases of chronic infectious complications following sinus floor elevation procedures are presented. To the authors' knowledge, it is the first time that well‐defined treatment protocols based on a combined endoscopic (FESS) and intra‐oral surgical approach are proposed. The positive, albeit preliminary, results obtained in this study seem to validate this treatment modality.
Thalidomide and dexamethasone vs. bortezomib and dexamethasone for melphalan refractory myeloma: a randomized study
Authors: Hjorth Martin , Hjertner Øyvind , Knudsen Lene Meldgaard , Gulbrandsen Nina , Holmberg Erik , Pedersen Per Trøllund , Andersen Niels Frost , Andréasson Björn , Billström Rolf , Carlson Kristina , Carlsson Margaretha S. , Flogegård Max , Forsberg Karin , Gimsing Peter , Karlsson Torbjörn , Linder Olle , Nahi Hareth , Othzén Annika , Swedin Agneta ,   for the Nordic Myeloma Study Group (NMSG)
Published: March 2012

AbstractObjectives:  Thalidomide and bortezomib have been frequently used for second‐line therapy in patients with myeloma relapsing after or refractory to initial melphalan‐based treatment, but no randomized trials have been published comparing these two treatment alternatives.Methods:  Thalidomide‐ and bortezomib‐naïve patients with melphalan refractory myeloma were randomly assigned to low‐dose thalidomide + dexamethasone (Thal‐Dex) or bortezomib + dexamethasone (Bort‐Dex). At progression on either therapy, the patients were offered crossover to the alternative drug combination. An estimated 300 patients would be needed for the trial to detect a 50% difference in median PFS between the treatment arms.Results:  After inclusion of 131 patients, the trial was prematurely closed because of low accrual. Sixty‐seven patients were randomized to Thal‐Dex and 64 to Bort‐Dex. Progression‐free survival was similar (median, 9.0 months for Thal‐Dex and 7.2 for Bort‐Dex). Response rate was similar (55% for Thal‐Dex and 63% for Bort‐Dex), but time to response was shorter (P < 0.05) and the VGPR rate higher (P < 0.01) for Bort‐Dex. Time‐to‐other treatment after crossover was similar (median, 13.2 months for Thal‐Dex and 11.2 months for Bort‐Dex), as was overall survival (22.8 months for Thal‐Dex and 19.0 for Bort‐Dex). Venous thromboembolism was seen in seven patients and cerebrovascular events in four patients in the Thal‐Dex group. Severe neuropathy, reactivation of herpes virus infections, and mental depression were more frequently observed in the Bort‐Dex group. In the quality‐of‐life analysis, no difference was noted for physical function, pain, and global quality of life. Fatigue and sleep disturbances were significantly more prevalent in the Bort‐Dex group.Conclusions:  Thalidomide (50–100 mg daily) in combination with dexamethasone seems to have an efficacy comparable with that of bortezomib and dexamethasone in melphalan refractory myeloma. However, the statistical strength of the results in this study is limited by the low number of included patients.
T‐type calcium channel blockade improves survival and cardiovascular function in thalassemic mice
Authors: Kumfu Sirinart , Chattipakorn Siriporn , Chinda Kroekkiat , Fucharoen Suthat , Chattipakorn Nipon 
Published: March 2012

AbstractObjectives:  Iron‐overload cardiomyopathy is a major cause of morbidity and mortality in patients with thalassemia. However, the precise mechanisms of iron entry and sequestration in the heart are still unclear. Our previous study showed that Fe2+ uptake in thalassemic cardiomyocytes are mainly mediated by T‐type calcium channels (TTCC). Nevertheless, the role of TTCC as well as other transporters such as divalent metal transporter1 (DMT1) and L‐type calcium channels (LTCC) as possible portals for iron entry into the heart in in vivo thalassemic mice under an iron‐overload condition has not been investigated.Methods:  An iron‐overload condition was induced in genetically altered β‐thalassemic mice and adult wild‐type mice by feeding them with an iron diet (0.2% ferrocene w/w) for 3 months. Then, blockers for LTCC (verapamil and nifedipine), TTCC (efonidipine), and DMT1 (ebselen) as well as iron chelator desferoxamine (DFO) were given for 1 month with continuous iron feeding.Results:  Treatment with LTCC, TTCC, DMT1 blockers, and DFO reduced cardiac iron deposit, cardiac malondialdehyde (MDA), plasma non‐transferrin‐bound iron, and improved heart rate variability and left ventricular (LV) function in thalassemic mice with iron overload. Only TTCC and DMT1 blockers and DFO reduced liver iron accumulation, liver MDA, plasma MDA, and decreased mortality rate in iron‐overloaded thalassemic mice.Conclusions:  DMT1, LTCC, and TTCC played important roles for iron entry in the thalassemic heart under an iron‐overloaded condition. Unlike LTCC blocker, TTCC blocker provided all benefits including attenuating iron deposit in both the heart and liver, reduced oxidative stress, and decreased mortality in iron‐overloaded mice.
An evidence‐based view on hyperbilirubinaemia
Authors: Dijk Peter H. , Hulzebos Christian V. 
Published: March 2012

AbstractIntroduction:  We conducted a review of the evidence which contributes to the current care of jaundiced newborn infants.Methods:  Literature was searched for reviews and randomized controlled trials (RCTs).Results:  Six Cochrane reviews and eight other reviews and eighteen recent RCTs are discussed.Conclusions:  Many children still suffer life‐long consequences of severe hyperbilirubinaemia, which could almost always have been prevented relatively easily. Up to date, guidelines summarizing the available evidence into unambiguous recommendations are needed to guide healthcare professionals in the prevention, diagnosis and treatment for infants with hyperbilirubinaemia.
Hyperoxia in the term newborn: more evidence is still needed for optimal oxygen therapy
Authors: Saugstad Ola Didrik 
Published: March 2012

AbstractIt took more than 30 years from the first observations that oxygen may be toxic during resuscitation till international guidelines changed to recommend that term and near term newborn infants should be resuscitated with air instead of 100% oxygen. There are still a number of unanswered questions related to oxygen therapy of the newborn infant. The newborn brain, lungs and other organs are susceptible to oxygen injury, and newborns still develop injury caused by hyperoxia.
Evidence for oxygen use in preterm infants
Authors: Triven Bashambu Monuj , Bhola Monika , Walsh Michele 
Published: March 2012

AbstractAim:  To review the evidence for optimal oxygen use in preterm infants.Results:  Clinicians have embraced lower saturation targets to minimize retinopathy of prematurity (ROP). Large randomized trials now have shown that while such targets reduce ROP, neonatal mortality is increased significantly.Conclusions:  Preterm infants should be resuscitated with blended oxygen (30–90%) targeted to avoid hyperoxia. Later, saturation management remains uncertain. Until ongoing trials and follow‐up are complete, it is prudent to avoid saturation of 85–89%.
Interventions to improve the oral feeding performance of preterm infants
Authors: Lau C , Smith EO 
Published: March 2012

AbstractAim:  Preterm infants have difficulty oral feeding. We hypothesized that a specific sucking and swallowing exercises vs. no intervention accelerate the attainment of independent oral feeding through a faster maturation of infants’ oral feeding skills (OFS).Methods:  Very low birthweight infants were randomized to a control, sucking and swallowing groups. Sucking consisted of active sucking on a pacifier, and swallowing of placing a milk bolus (0.05–0.2 mL) on the tongue where the bolus rests prior to entering the pharynx. Primary outcome was days from start to independent oral feeding (SOF‐IOF). Secondary outcomes included overall transfer (OT, % volume taken/volume prescribed), proficiency (PRO, % volume taken at 5 min/volume prescribed), rate of transfer (RT, mL/min) over the entire feeding and infants’ OFS levels. OFS levels were defined by PRO and RT.Results:  Days from SOF to IOF vs controls (21 ± 2) were similar for the sucking group (19 ± 2) and shorter for the swallowing group (15 ± 2; p = 0.019). Only the latter infants demonstrated more mature OFS levels than controls.Conclusion:  The swallowing exercise is an efficacious intervention in facilitating the attainment of independent oral feeding, but not the sucking exercise. We speculate that the swallowing benefit resulted from an accelerated maturation of infants’ OFS levels.
Structural and Dielectric Studies of Nanocrystalline Calcium Substituted Magnesium Titanate Synthesized Through an Auto‐Igniting Combustion Technique
Authors: Suresh Madukayil Kunjoonju , Thomas Jijimon Kumpukattu , Sreemoolanadhan Hariharan , George Chandy Nellimmoottil , John Annamma , Solomon Sam , Wariar Palakkattumala Ramachandra Sobhana , Koshy Jacob 
Published: March 2012

Nanocrystalline calcium substituted magnesium titanate was synthesized through an auto‐igniting combustion technique. The phase constitution of the powder was examined using X‐ray diffraction, thermal analyses, and spectroscopic studies. The particle size of ~30 nm was obtained, and that could be sintered to 96% of the theoretic density at 1150°C/2 h. The microstructure of the sintered surface was examined using scanning electron microscopy. The quality factor (Qu × f ) of 65,110 GHz, dielectric constant (εr) of 20.25, and temperature coefficient of resonant frequency (τf) of ~0 ppm/°C suggest that the sintered sample can be used for microwave applications.
Capacity for Freedom – Using a New Poverty Measure to Look at Regional Differences in Living Standards within Australia
Authors: CALLANDER EMILY J. , SCHOFIELD DEBORAH J. , SHRESTHA RUPENDRA N. 
Published: March 2012

AbstractUsing a recently developed measure of multidimensional poverty, the Freedom Poverty Measure, the difference in poverty rates of major cities, inner regional, and other areas have been compared. The population living in ‘other areas’ had the highest proportion of individuals living in freedom poverty. Those in inner regional areas (P = 0.0303) and those in major cities (P < 0.0001) were significantly less likely to be in freedom poverty than those in ‘other areas’. However, when breaking the analysis down to look at the different poverty rates for different age groups across the three regional classifications, it was found that there was no difference in the likelihood of being in freedom poverty between children in inner regional and other areas, adults in inner regional and other areas, and older people in inner regional and other areas. This may indicate that the disadvantage experienced by those living in regional centres has been overlooked in the past and is an emerging contemporary issue for health and education equity as well as economic equality.
Urban Homebodies: Embodiment, Masculinity, and Domesticity in Inner Sydney
Authors: GORMAN‐MURRAY ANDREW 
Published: March 2012

AbstractGender is a key lens for interpreting meanings and practices of home(making) in urban neighbourhoods, but while there is a rich understanding of women's experiences, there is a paucity of work on men's. To advance insights into gendered dimensions of home in urban contexts, this paper discusses men's embodied experiences of home in inner Sydney, drawing data from fieldwork with 52 men. This focus is prompted by scholarly and policy concern with men's emotional wellbeing. I seek to understand how these men deploy their homes to pursue work/life balance and how domestic activities contribute to their emotional wellbeing. I find that these men use their bodies as emotional and sensuous instruments to manage the interplay of work(place) and home(place). Moreover, I suggest that these men's embodied emotional engagements with domesticity reconfigure the gendered practices and imaginaries of homelife, and challenge persistent gender inequalities and stereotypes by providing alternatives to hegemonic masculinity.
Preliminary Investigations of the Effect of Lipophilic Analogues of the Active Metabolite of Isoniazid Toward Bacterial and Plasmodial Strains
Authors: Delaine Tamara , Bernardes‐Génisson Vania , Quémard Annaïk , Constant Patricia , Cosledan Frédéric , Meunier Bernard , Bernadou Jean 
Published: March 2012

Five lipophilic analogues 1–5 of the active metabolite of the antitubercular drug isoniazid (INH), selected as inhibitors of Mycobacterium smegmatis and Mycobacterium tuberculosis growth, were evaluated for their activity against Corynebacterium glutamicum (lacking in InhA activity), Escherichia coli (to test mycobacteria selectivity), and Plasmodium falciparum (as possible parasite target). Compound 3 was the only one that did not inhibit C. glutamicum growth. The poor InhA inhibitors 1 and 2 were able to inhibit C. glutamicum and their anti(myco)bacterial mechanisms of action involve targets other than InhA. For the effective InhA inhibitors 4 and 5, also active against C. glutamicum and M. tuberculosis strains, more than one pathway should be envisaged to explain their actions. Pyridine‐base ring analogues (1, 2, and 3) have no ability to inhibit the growth of E. coli even at a high concentration. Compound 3 thus exhibited a selective inhibitory action toward M. tuberculosis, while it was inactive on C. glutamicum and on E. coli growth. It presented an activity profile similar to that of INH suggesting InhA inhibition as one of the possible mechanisms of action. Finally, although a homologue of the reductase InhA exists in the FAS‐II system of P. falciparum, 3 was unable to display antiplasmodial activity.
Involvement of the γ‐Secretase‐Mediated EphA4 Signaling Pathway in Synaptic Pathogenesis of Alzheimer's Disease
Authors: Matsui Chiyuki , Inoue Eiji , Kakita Akiyoshi , Arita Kohei , Deguchi‐Tawarada Maki , Togawa Aki , Yamada Akio , Takai Yoshimi , Takahashi Hitoshi 
Published: March 2012

AbstractLoss of synapses is associated with cognitive impairment in Alzheimer's disease (AD). However, the molecular mechanism underlying this synaptic impairment is not well understood. EphA4 is a substrate of γ‐secretase, and the γ‐secretase‐cleaved EphA4 intracellular domain (EICD) is known to enhance the formation of dendritic spines via activation of the Rac signaling pathway. Here, we show that the amount of Rac1 is significantly reduced, and correlated with the level of EICD in the frontal lobes of AD patients. Biochemical analyses revealed that the amount of membrane‐associated EICD was decreased and strongly correlated with the level of membrane‐associated Rac1, which is considered to be active Rac1. The synaptic scaffolding protein, postsynaptic density (PSD)‐95, was specifically decreased in AD, and the amount of PSD‐95 correlated with the level of Rac1. Moreover, the amounts of Rac1 and PSD‐95 were negatively correlated with the extent of tau phosphorylation, which is crucial for neurofibrillary tangle formation. These results suggest that attenuation of the EICD‐mediated Rac signaling pathway is involved in the synaptic pathogenesis of AD.
Transnasal esophagogastroduodenoscopy for placement of nasoenteric feeding tubes in patients with severe upper gastrointestinal diseases
Authors: ZHANG Li , HUANG Yong Hui , YAO Wei , CHANG Hong , GUO Chang Ji , LIN San Ren 
Published: March 2012

OBJECTIVE:  To evaluate the feasibility and efficacy of small‐caliber transnasal esophagogastroduodenoscopy for the placement of nasoenteric feeding tubes (NET) in patients with severe upper gastrointestinal (GI) diseases.METHODS:  Between January 2007 and March 2010, 51 patients underwent transnasal endoscopy for the placement of NET in Peking University Third Hospital. Indications for NET included esophageal stricture or gastric outlet obstruction because of corrosive esophagitis or gastritis, partial obstruction due to malignancy, stenosis in stoma or efferent loop, gastroparesis, metallic stent in upper GI tract, tracheoesophageal fistula, severe acute pancreatitis, anorexia nervosa and intensive care patients. The tubes were endoscopically placed using the guidewire technique. The position of the tube was confirmed by the immediate second endoscopy or abdominal X‐ray. If the initiate placement was not correct, an adjustment or a second placement was conducted immediately.RESULTS:  Initial post‐pyloric placement of NET was achieved in 43 of 51 patients (84.3%), but the total success rate reached 98.0% (50/51) after the second placement. The time required for the procedure ranged from 10 to 35 min, with a median time of 20.4 min. Epistaxis occurred in 2 patients. There were no complications of hemorrhage, perforation or aspiration.CONCLUSION:  The transnasal endoscopic placement of NET was feasible in patients with upper GI diseases, especially in those with changed anatomy.
On the Generalized Bootstrap for Sample Surveys with Special Attention to Poisson Sampling
Authors: Beaumont Jean‐François , Patak Zdenek 
Published: March 2012

Résumé Nous étudions la technique du bootstrap généralisé pour des plans de sondage généraux. Nous nous concentrons principalement sur l’estimation bootstrap de la variance mais nous étudions également les propriétés empiriques des intervalles de confiance bootstrap obtenus en utilisant la méthode des percentiles. Le bootstrap généralisé consiste à générer aléatoirement des poids bootstrap de telle sorte que les deux (ou plus) premiers moments selon le plan de l’erreur d’échantillonnage soient approchés par leurs moments correspondants selon le mécanisme bootstrap. On peut voir la plupart des méthodes bootstrap dans la littérature comme étant des cas particuliers du bootstrap généralisé. Nous discutons de considérations telles que le choix de la distribution utilisée pour générer les poids bootstrap, le choix du nombre de répliques bootstrap et la présence possible de poids bootstrap négatifs. Nous décrivons d’abord le bootstrap généralisé pour l’estimateur linéaire de Horvitz‐Thompson et considérons ensuite les estimateurs non linéaires tels que ceux définis au moyen d’équations d’estimation. Nous développons également deux façons d’appliquer le bootstrap à l’estimateur par la régression généralisée du total d’une population. Nous étudions plus en profondeur le cas de l’échantillonnage de Poisson qui est souvent utilisé pour sélectionner des échantillons dans les enquêtes sur les indices de prix effectuées par les agences statistiques nationales dans le monde. Pour l’échantillonnage de Poisson, nous considérons une approche par pseudo‐population et montrons que les poids bootstrap qui en résultent capturent les trois premiers moments sous le plan de l’erreur d’échantillonnage. Nous utilisons une étude par simulation et un exemple avec des données d’enquêtes réelles pour illustrer la théorie.
Can they keep up with climate change? – Integrating specific dispersal abilities of protected Odonata in species distribution modelling
Authors: JAESCHKE ANJA , BITTNER TORSTEN , REINEKING BJÖRN , BEIERKUHNLEIN CARL 
Published: March 2012

Abstract.  1. The effects of climate change on the distribution of species are typically inferred using bioclimatic envelope models, assuming either no or unrestricted dispersal abilities. Information on species‐specific dispersal abilities, especially of animals, is rarely incorporated.2. We analysed European records of two damselflies and four dragonflies protected by the Habitats Directive of the European Union. In addition to no or unrestricted dispersal scenarios, we considered species‐specific dispersal distances based on literature information to improve realism in assessing conservation implications of climate change. The climate model HadCM3 and the emission scenario A2 were applied to project potential changes in occurrence probabilities up to 2035. As modelling algorithms, generalised linear models (GLM) and boosted regression trees (BRT) were used.3. The species Coenagrion ornatum, Coenagrion mercuriale and Ophiogomphus cecilia are projected to lose range (up to −68%) when incorporating specific dispersal distances, while they are projected to extend their range (up to +23%) in the unrestricted dispersal scenario. Furthermore, suitable climatic conditions tend to decline for Leucorrhinia albifrons and Leucorrhina caudalis (up to −73%), whereas Leucorrhinia pectoralis is projected to gain distribution area (up to +37%) assuming either species‐specific or unrestricted dispersal and subsequently successful breeding. Cross‐validated model performance (AUC values) ranges between 0.77 and 0.92.4. The integration of species‐specific knowledge about dispersal distances in species distribution models promises to improve estimates of potential range changes and their implications for conservation management. Contrasting model results under different dispersal scenarios highlight the importance of research on species’ ecology including dispersal distances.