bluuebunny/crossref_metadata_2025_split huggingface dataset:
Approaching the Holy with Thomas B. Dozeman and Rudolf Otto
Authors: Shah Bruno M. 
Published: June 2011

AbstractThis article considers Thomas B. Dozeman's ecumenically orientated and biblically situated theology of ministry (Holiness and Ministry, 2008) by assessing his utilisation of Rudolf Otto's ‘idea of the holy’. Despite significant promise, basic obstacles to appreciating Dozeman's theology of ministry appear to a Catholic perspective. In order to understand the reason for this tension, Dozeman's methodology is analysed. Because of the particular way in which he incorporates the work of Rudolf Otto on the nature of holiness, Dozeman is unable to present a model of ministry wherein ‘word’ and ‘sacrament’ exist in harmony, or a model of ministry which looks to Jesus Christ for its formal type – two issues which any Christian theology of ministry must find problematic. In general, ecumenical and ministerial theologies are ill served by methodologies which are based in a transcendental anthropology of holy experience.
Albert Camus: The challenge of the unbeliever
Authors: Blackburn Vivienne 
Published: June 2011

AbstractAlbert Camus (1913–60), novelist, essayist, journalist and member of the French Resistance, reflected in his work the turbulent period through which he lived. His powerful portrayal of a world dominated by violence and suffering resonates with us today. An atheist, Camus had been, as a young man, drawn to the Christian faith: his postgraduate thesis was on the development of early Christianity. The thesis reveals the nature of the attraction which the faith held for Camus, and the unresolved problems which prevented him from embracing it. In maturity, Camus sought rather to convince fellow human beings of the need to work together to reduce suffering, without relying on belief in a transcendent being. He respected Christians, however, and welcomed dialogue with them. This article examines the possible basis for such dialogue revealed by the thesis. It goes on to consider the possibilities opened up by contemporary theology for dialogue between Christians and those unbelievers who share the perspective, the doubts and concerns of Albert Camus.
Explaining the Accountability of Independent Agencies: The Importance of Political Salience
Authors: Koop Christel 
Published: June 2011

AbstractIndependent agencies are exempted from the accountability mechanisms inherent in the ministerial hierarchy. To compensate for this, politicians incorporate all kinds of information and reporting requirements into the statutes of the organizations. However, the degree to which this occurs varies considerably, which raises the question: Why are some agencies are made more accountable than others? This study examines the impact of political salience on degrees of accountability, controlling for other potential explanations. Using original data on 103 independent agencies in the Netherlands, the analysis demonstrates that salience has a twofold effect. First, agencies dealing with more salient issues are made more politically accountable. Second, agencies whose statutes are written when the issue of accountability is more salient are also subject to higher degrees of accountability. Other explanatory factors are the number of veto players and the legal basis of the organization.
Nonprobabilistic anytime algorithm for high-quality trajectories in high-dimensional spaces
Authors: Vázquez Andrés S. , Adán Antonio 
Published: June 2011

SUMMARYThis paper proposes a feasible variation of approximate grid-based path-planning methods, which have been replaced with probabilistic methods nowadays, due mainly to their impracticality in high-dimensional spaces. Our aim is to demonstrate that, with an incremental exploration of the CSpace by means of Interpolated walk primitives and ANY-Time algorithms, we can generate – online – high-quality solutions that can be compared with probabilistic methods and can even improve some aspects, such as the completeness. Computational time, path smoothness, path clearance, and path distance are the qualifiers used to evaluate the path planner. These quality factors are critical in robotics. In fact, in both mobile and industrial robots, the computational time is a primary requirement to work online, the clearance gives security to the movements of the robot, and the smoothness can prolong the life of the mechanical components. Our method has been compared to probabilistic path planners, with the feasibility and benefits of our algorithm being proved in terms of the quality factors aforementioned.
Adjusting Astronomical Practices: The “Carte du Ciel”, the democratic rules and the circulation of opinions at the end 19th century
Authors: Lamy Jérôme 
Published: June 2011

AbstractLaunched in 1887, the “Carte du Ciel” was an international project aiming at photographing the entirety of the celestial vault. Tasks required for this huge undertaking were divided among 18 observatories around the globe. Instruments were standardized and a series of international conferences established operating modes and prescribed norms to be followed everywhere. In each observatory, however, the drive toward uniformity ran into a variety of minor technical and practical problems. In this paper, we examine the strategies mobilized by observers to tinker with stated rules and adapt them to their own experience as astronomers. To underscore the tension between normative prescriptions and individual practices, we consider theBulletin of the Permanent International Committee for the execution of the Carte du Cielas an informal forum where various queries raised and arrangements adopted were shared among the scientific community.
The creation of the International Astronomical Union as a result of scientific diplomacy
Authors: Saint-Martin Arnaud 
Published: June 2011

AbstractAfter World War I, the foundation of the International Astronomical Union delimited a space for a new form of internationality, which led to a rapid change in the way astronomical research had previously been pursued. This structure was to be a sort of parliament of astronomical nations which planned to supervise scientific programs and to rationalise inter-observatory cooperation. In this article, I will discuss the sociological aspects of this institutional process and introduce the idea of ‘scientific diplomacy’.
From Giza to the Pantheon: astronomy as a key to the architectural projects of the ancient past
Authors: Magli Giulio 
Published: June 2011

AbstractIn many of the “wonders” of our past, information about their meaning and scope has been encoded in the form of astronomical alignments to celestial bodies. Therefore, in many cases, understanding the ideas of the ancient architects turns out to be connected with the study of the relationship of their cultures with the sky. This is the aim of archaeoastronomy, a discipline which is a quite efficacious tool in unraveling the original projects of many monuments. This issue is briefly discussed here by means of three examples taken from three completely different cultures and historical periods: the so-called “air shafts” of the Great Pyramid, the urban layout of the capital of the Incas, and the design of the Pantheon.
Michelangelo, Copernicus and the Sistine chapel
Authors: Shrimplin Valerie 
Published: June 2011

AbstractIt is argued that Copernican astronomy is a key theme in Michelangelo's fresco of the Last Judgment in the Sistine Chapel, and was incorporated with the knowledge, consent and approval of the Popes concerned. In Christian art, the iconography of the Last Judgment (depicting the three parts of the universe: heaven, Earth and hell) was traditionally based on a layered structure relating to perceptions of the flat Earth covered by the dome of heaven according to biblical cosmology. In Michelangelo's revolutionary work, Christ is significantly depicted as a beardless Apollonian Sun-god, positioned in the centre of a dramatic circular design rather than at the top of a layered format. This appears to relate to the traditional Christian analogy between the deity and the astronomical feature of the sun, the neoplatonic cult of Sun-symbolism and sources in Dante. More importantly, the influence of the Copernican theory of heliocentricity is argued, since interest in such ideas in papal circles is demonstrated at exactly the time of the commission of the painting (1533). This provides important evidence of papal support for Copernican heliocentricity as early as the 1530s.
Astronomy, technology development and industry
Authors: Vigroux Laurent 
Published: June 2011

AbstractAstronomy is perhaps the best example of fundamental research aiming to increase our knowledge well beyond our human neighborhood. But astronomy is also a Big Science, which is partly technology-driven. Progress in observational capabilities is due to progress in detectors, telescopes, satellites, etc. I use three examples –radio astronomy, adaptive optics and detectors– to describe the complex interactions between astronomy, technology development and industry. I conclude by a short description of the global economic impact of astronomy.
Improving the scientific literacy of Aboriginal students through astronomy
Authors: Bhathal Ragbir 
Published: June 2011

AbstractSeventy per cent of Aboriginal students drop out of school before the end of their secondary school years and very few go on to do science at the Higher School Certificate level. As a result of this statistics reveal that only 0.003% of the 9000 university science graduates in 2005 in Australia were of Aboriginal origin. This paper discusses an astronomy project which seeks to improve the scientific literacy of Aboriginal students so as to motivate them to take up careers in science and engineering.
Astronomical education in Tajikistan. Project TAJASTRO
Authors: Ibadinov Khursandkul I. , Rahmonov A. A. 
Published: June 2011

AbstractThe centre of astronomy in Tajikistan is the Institute of Astrophysics of the Academy of Sciences of Tajikistan. This institute carries out scientific research and contributes to the preparation of the astronomical staff and to astronomical education. The reform of education in Tajikistan continues and now astronomy is studied in schools (together with physics) and at universities. The Tajik State Pedagogical University resumed in 2007 the training of teachers in physics and astronomy. Since 1999 the Tajik National University (TNU) offers a a specialty in astronomy. In 2006 is restored the Small Academy of Sciences (SAS) of Tajikistan. There is a planetarium in Khujand and in 2006 the Institute of Astrophysics, TNU and the Astronomical Society of Tajikistan, along with the support IBSP/UNESCO, organised the Training Methodical Center (TMC) “TAJASTRO” at the Hisar astronomical observatory for students, graduate students, young scientists, and teachers at secondary schools.
Popularising astronomy in Iran
Authors: Tafreshi Babak A. 
Published: June 2011

AbstractThe interest to astronomy has incredibly risen in the younger generation of Iranians during the last two decades. By the end of the devastating war with Iraq, science popularisation activities started again in Iran and with only a handful of astronomers and few dozens of serious amateur astronomers in the whole country in late 1980s now there are thousands of amateur astronomers (60% female on average) and over 100 professional astronomers propelling the fun and science of astronomy in the society.
Astrokeltoi: an archaeoastronomical project in the Celtiberian area
Authors: Mejuto Javier , Cerdeño Maria Luisa , Caderot Gracia Rodríguez , Rodríguez César 
Published: June 2011

AbstractWe present an archaeoastronomical project as a part of a cultural heritage project on Celtiberian cultures. Following a study on the Iron Age's sky and its relationship with Celtiberian cultures, we present the Celtiberian Archaeological Route. This information is presented to visitors in relation to the landscape and the archaeological site. The ASTROKELTOI project attempts to link the archaeoastronomical popularisation to its cultural and historical frameworks.
Introducing astronomy: a way to renovate school curricula
Authors: Godunova Vira 
Published: June 2011

AbstractOne of the most urgent tasks facing society today is to make science more attractive to the younger generation and to foster the continuous improvement of the knowledge and skills. These objectives assume ever greater importance because, firstly, young people are opting less and less for scientific studies, secondly, we need to establish new starting points for them in order that they could better understand and improve our changing world. To achieve these aims, it is necessary to expand innovation in secondary education. In this paper, a few suggestions, which can help assess and prioritize the usefulness of astronomy-related material for improving the educational process, are presented.
Inhibiting myosin-ATPase reveals a dynamic range of mitochondrial respiratory control in skeletal muscle
Authors: Perry Christopher G. R. , Kane Daniel A. , Lin Chien-Te , Kozy Rachel , Cathey Brook L. , Lark Daniel S. , Kane Constance L. , Brophy Patricia M. , Gavin Timothy P. , Anderson Ethan J. , Neufer P. Darrell 
Published: June 2011

Assessment of mitochondrial ADP-stimulated respiratory kinetics in PmFBs (permeabilized fibre bundles) is increasingly used in clinical diagnostic and basic research settings. However, estimates of the Km for ADP vary considerably (~20–300 μM) and tend to overestimate respiration at rest. Noting that PmFBs spontaneously contract during respiration experiments, we systematically determined the impact of contraction, temperature and oxygenation on ADP-stimulated respiratory kinetics. BLEB (blebbistatin), a myosin II ATPase inhibitor, blocked contraction under all conditions and yielded high Km values for ADP of &gt;~250 and ~80 μM in red and white rat PmFBs respectively. In the absence of BLEB, PmFBs contracted and the Km for ADP decreased ~2–10-fold in a temperature-dependent manner. PmFBs were sensitive to hyperoxia (increased Km) in the absence of BLEB (contracted) at 30 °C but not 37 °C. In PmFBs from humans, contraction elicited high sensitivity to ADP (Km&lt;100 μM), whereas blocking contraction (+BLEB) and including a phosphocreatine/creatine ratio of 2:1 to mimic the resting energetic state yielded a Km for ADP of ~1560 μM, consistent with estimates of in vivo resting respiratory rates of &lt;1% maximum. These results demonstrate that the sensitivity of muscle to ADP varies over a wide range in relation to contractile state and cellular energy charge, providing evidence that enzymatic coupling of energy transfer within skeletal muscle becomes more efficient in the working state.
ontoCAT: an R package for ontology traversal and search
Authors: Kurbatova Natalja , Adamusiak Tomasz , Kurnosov Pavel , Swertz Morris A. , Kapushesky Misha 
Published: June 2011

Abstract
Motivation: There exist few simple and easily accessible methods to integrate ontologies programmatically in the R environment. We present ontoCAT—an R package to access ontologies in widely used standard formats, stored locally in the filesystem or available online. The ontoCAT package supports a number of traversal and search functions on a single ontology, as well as searching for ontology terms across multiple ontologies and in major ontology repositories.
Availability: The package and sources are freely available in Bioconductor starting from version 2.8: http://bioconductor.org/help/bioc-views/release/bioc/html/ontoCAT.html or via the OntoCAT website http://www.ontocat.org/wiki/r.
Contact: natalja@ebi.ac.uk; natalja@ebi.ac.uk
Metab: an R package for high-throughput analysis of metabolomics data generated by GC-MS
Authors: Aggio Raphael , Villas−Bôas Silas Granato , Ruggiero Katya 
Published: June 2011

Abstract
Motivation: The Automated Mass Spectral Deconvolution and Identification System (AMDIS) is freeware extensively applied in metabolomics. However, datasets processed by AMDIS require extensive data correction, filtering and reshaping to create reliable datasets for further downstream analysis. Performed manually, these processes are laborious and extremely time consuming. Furthermore, manual corrections increase the chance of human error and can introduce additional technical variability to the data. Thus, an automated pipeline for curating GC-MS data is urgently needed.
Results: We present the Metab R package designed to automate the pipeline for analysis of metabolomics GC-MS datasets processed by AMDIS.
Availability: The Metab package, the AMDIS library and the reference ion library are available at www.metabolomics.auckland.ac.nz/index.php/downloads.
Contact: k.ruggiero@auckland.ac.nz
CytoscapeRPC: a plugin to create, modify and query Cytoscape networks from scripting languages
Authors: Bot Jan J. , Reinders Marcel J. T. 
Published: June 2011

Abstract
Summary: CytoscapeRPC is a plugin for Cytoscape which allows users to create, query and modify Cytoscape networks from any programming language which supports XML-RPC. This enables them to access Cytoscape functionality and visualize their data interactively without leaving the programming environment with which they are familiar.
Availability: Install through the Cytoscape plugin manager or visit the web page: http://wiki.nbic.nl/index.php/CytoscapeRPC for the user tutorial and download.
Contact: j.j.bot@tudelft.nl; j.j.bot@tudelft.nl
BRISK—research-oriented storage kit for biology-related data
Authors: Tan Alan , Tripp Ben , Daley Denise 
Published: June 2011

Abstract
Motivation: In genetic science, large-scale international research collaborations represent a growing trend. These collaborations have demanding and challenging database, storage, retrieval and communication needs. These studies typically involve demographic and clinical data, in addition to the results from numerous genomic studies (omics studies) such as gene expression, eQTL, genome-wide association and methylation studies, which present numerous challenges, thus the need for data integration platforms that can handle these complex data structures. Inefficient methods of data transfer and access control still plague research collaboration. As science becomes more and more collaborative in nature, the need for a system that adequately manages data sharing becomes paramount.
Results: Biology-Related Information Storage Kit (BRISK) is a package of several web-based data management tools that provide a cohesive data integration and management platform. It was specifically designed to provide the architecture necessary to promote collaboration and expedite data sharing between scientists.
Availability and Implementation: The software, documentation, Java source code and demo are available at http://genapha.icapture.ubc.ca/brisk/index.jsp. BRISK was developed in Java, and tested on an Apache Tomcat 6 server with a MySQL database.
Contact: denise.daley@hli.ubc.ca
Integration and visualization of host–pathogen data related to infectious diseases
Authors: Driscoll Timothy , Gabbard Joseph L. , Mao Chunhong , Dalay Oral , Shukla Maulik , Freifeld Clark C. , Hoen Anne Gatewood , Brownstein John S. , Sobral Bruno W. 
Published: June 2011

Abstract
Motivation: Infectious disease research is generating an increasing amount of disparate data on pathogenic systems. There is a growing need for resources that effectively integrate, analyze, deliver and visualize these data, both to improve our understanding of infectious diseases and to facilitate the development of strategies for disease control and prevention.
Results: We have developed Disease View, an online host–pathogen resource that enables infectious disease-centric access, analysis and visualization of host–pathogen interactions. In this resource, we associate infectious diseases with corresponding pathogens, provide information on pathogens, pathogen virulence genes and the genetic and chemical evidences for the human genes that are associated with the diseases. We also deliver the relationships between pathogens, genes and diseases in an interactive graph and provide the geolocation reports of associated diseases around the globe in real time. Unlike many other resources, we have applied an iterative, user-centered design process to the entire resource development, including data acquisition, analysis and visualization.
Availability and Implementation: Freely available at http://www.patricbrc.org; all major web browsers supported.
Contact: cmao@vbi.vt.edu
Supplementary information: Supplementary data are available at Bioinformatics online.
Developmental Stage-dependent Persistent Impact of Propofol Anesthesia on Dendritic Spines in the Rat Medial Prefrontal Cortex
Authors: Briner Adrian , Nikonenko Irina , De Roo Mathias , Dayer Alexandre , Muller Dominique , Vutskits Laszlo 
Published: June 2011

Background
Recent observations demonstrate that anesthetics rapidly impair synaptogenesis during neuronal circuitry development. Whether these effects are lasting and depend on the developmental stage at which these drugs are administered remains, however, to be explored.

Methods
Wistar rats received propofol anesthesia at defined developmental stages during early postnatal life. The acute and long-term effects of these treatments on neuronal cytoarchitecture were evaluated by Neurolucida and confocal microscopy analysis after iontophoretic injections of Lucifer Yellow into layer 5 pyramidal neurons in the medial prefrontal cortex. Quantitative electron microscopy was applied to investigate synapse density.

Results
Layer 5 pyramidal neurons of the medial prefrontal cortex displayed intense dendritic growth and spinogenesis during the first postnatal month. Exposure of rat pups to propofol at postnatal days 5 and 10 significantly decreased dendritic spine density, whereas this drug induced a significant increase in spine density when administered at postnatal days 15, 20, or 30. Quantitative electron microscopy revealed that the propofol-induced increase in spine density was accompanied by a significant increase in the number of synapses. Importantly, the propofol-induced modifications in dendritic spine densities persisted up to postnatal day 90.

Conclusion
These new results demonstrate that propofol anesthesia can rapidly induce significant changes in dendritic spine density and that these effects are developmental stage-dependent, persist into adulthood, and are accompanied by alterations in synapse number. These data suggest that anesthesia in the early postnatal period might permanently impair circuit assembly in the developing brain.