bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structuring a scientific publication—what authors should pay attention to
Authors: Herbst Elmar , Kopf Sebastian , Günther Daniel ,   AGA Research Committee
Published: May 2024

AbstractThis article gives a brief overview on how to prepare a scientific publication. Considerations relevant before preparing the manuscript are presented (i.e., preparation of a bulleted outline), and tips are provided for choosing an appropriate and catchy title. When preparing a manuscript, the introduction section is often too long. Here, authors should directly present the scientific/clinical problem, current knowledge on the topic, and the research question, followed by a clear hypothesis. The methods section should be prepared as a detailed recipe in order to make the study reproducible for others. The results section should focus on the primary and secondary endpoints of the study, with key results highlighted in figures and tables. In the discussion section, these endpoints should be discussed on the basis of current literature after a short summary of the main findings. Importantly, results should be discussed on the basis of scientific and clinical relevance rather than in terms of statistical significance.
Prediction and optimization kerf width in laser beam machining of titanium alloy using genetic algorithm tuned adaptive neuro-fuzzy inference system
Authors: Ji Min , Thangaraj Muthuramalingam , Devaraj Saravanakumar , Machnik Ryszard , Karkalos Nikolaos E. , Karmiris-Obratański Panagiotis 
Published: May 2024

AbstractIn the power diode laser beam machining (DLBM) process, the kerf width (KW) and surface roughness (SR) are important factors in evaluating the cutting quality of the machined specimens. Apart from determining the influence of process parameters on these factors, it is also very important to adopt multi-response optimization approaches for them, in order to achieve better processing of specimens, especially for hard-to-cut materials. In this investigation, adaptive neuro-fuzzy inference system (ANFIS) and genetic algorithm tuned ANFIS (GA-ANFIS) were used to predict the KW on a titanium alloy workpiece during DLBM. Five machining process factors, namely power diode, standoff distance, feed rate, duty cycle, and frequency, were used for the development of the model due to their correlation with KW. As in some cases, traditional soft computing methods cannot achieve high accuracy; in this investigation, an endeavor was made to introduce the GA-assisted ANFIS technique to predict kerf width while machining grooves in a titanium alloy workpiece using the DLBM process based on experimental results of a total of 50 combinations of the process parameters. It was observed that FIS was tuned well using the ANN in the ANFIS model with an R2 value of 0.99 for the training data but only 0.94 value for the testing dataset. The predicting performance of the GA-ANFIS model was better with less value for error parameters (MSE, RMSE, MAE) and a higher R2 value of 0.98 across different folds. Comparison with other state-of-the-art models further indicated the superiority of the GA-ANFIS predictive model, as its performance was superior in terms of all metrics. Finally, the optimal process parameters for minimum KW and SR, from gray relational–based (GRB) multi-response optimization (MRO) approach, were found as 20 W (level 2) for laser power, 22 mm (level 5) for standoff distance, 300 mm/min (level 5) for feed rate, 85% (level 5) for duty cycle, and 18 kHz (level 3) for frequency.
A biharmonic analogue of the Alt–Caffarelli problem
Authors: Grunau Hans-Christoph , Müller Marius 
Published: May 2024

AbstractWe study a natural biharmonic analogue of the classical Alt–Caffarelli problem, both under Dirichlet and under Navier boundary conditions. We show existence, basic properties and $$C^{1,\alpha }$$

C

1
,
α

-regularity of minimisers. For the Navier problem we also obtain a symmetry result in case that the boundary data are radial. We find this remarkable because the problem under investigation is of higher order. Computing radial minimisers explicitly we find that the obtained regularity is optimal.
Cycle-Star Motifs: Network Response to Link Modifications
Authors: Bakrani Sajjad , Kiran Narcicegi , Eroglu Deniz , Pereira Tiago 
Published: May 2024

AbstractUnderstanding efficient modifications to improve network functionality is a fundamental problem of scientific and industrial interest. We study the response of network dynamics against link modifications on a weakly connected directed graph consisting of two strongly connected components: an undirected star and an undirected cycle. We assume that there are directed edges starting from the cycle and ending at the star (master–slave formalism). We modify the graph by adding directed edges of arbitrarily large weights starting from the star and ending at the cycle (opposite direction of the cutset). We provide criteria (based on the sizes of the star and cycle, the coupling structure, and the weights of cutset and modification edges) that determine how the modification affects the spectral gap of the Laplacian matrix. We apply our approach to understand the modifications that either enhance or hinder synchronization in networks of chaotic Lorenz systems as well as Rössler. Our results show that the hindrance of collective dynamics due to link additions is not atypical as previously anticipated by modification analysis and thus allows for better control of collective properties.
Thematic coverage and readability of online patient information on cochlear implant care
Authors: Levi Anna , Leinung Martin , Helbig Silke , Guderian Daniela , Issing Christian , Weissgerber Tobias , Hartmann Maria , Stöver Timo , Loth Andreas G. 
Published: May 2024

Abstract
Introduction
The treatment of patients with a cochlear implant (CI) is usually an elective, complex and interdisciplinary process. As an important source of information, patients often access the internet prior to treatment. The quality of internet-based information regarding thematic coverage has not yet been analysed in detail. Therefore, the aim of this study was to analyse the information on CI care available on the internet regarding its thematic coverage and readability.

Material methods
Eight search phrases related to CI care were defined as part of the study. A checklist for completeness of thematic coverage was then created for each search phrase. The current German CI clinical practice guideline and the white paper on CI care in Germany were used as a basis. As a further parameter, readability was assessed using Flesch Reading Ease Scores. The search phrases were used for an internet search with Google. The first ten results were then analysed with regard to thematic coverage, readability and the provider of the website.

Results
A total of 80 websites were identified, which were set up by 54 different providers (16 providers were found in multiple entries) from eight different provider groups. The average completeness of thematic coverage was 41.6 ± 28.2%. Readability according to the Flesch Reading Ease Score was categorised as "hard to read" on average (34.7 ± 14.2 points, range: 0–72). There was a negative statistically significant correlation between the thematic coverage of content and readability (Spearman's rank correlation: r = − 0.413, p = 0.00014).

Summary
The completeness of thematic coverage of information on CI care available on the internet was highly heterogeneous and had a significant negative correlation with the readability. This result should be taken into account by both the providers of internet information and by patients when using internet-based information on CI care and help to further improve the quality of web-based information.
Persistent increased severity of cannabis use disorder symptoms in adolescents compared to adults: a one-year longitudinal study
Authors: Lees Rachel , Lawn Will , Petrilli Kat , Brown Amelia , Trinci Katie , Borissova Anya , Ofori Shelan , Mokrysz Claire , Curran H. Valerie , Hines Lindsey A. , Freeman Tom P. 
Published: May 2024

AbstractAdolescence is a developmental period characterised by increased vulnerability to cannabis use disorder (CUD). However, previous investigations of this vulnerability have relied on cross-sectional comparisons and lack a detailed assessment of cannabis quantity, a potentially important confounding factor. Here, we aimed to investigate the one-year course of CUD in adolescents compared to adults who currently use cannabis, adjusting for a comprehensive measure of cannabis quantity. Data are from a one-year observational longitudinal study (CannTeen) of adolescents and adults who currently used cannabis regularly with five waves of assessment at 3-monthly intervals, based in London, UK. Participants were n = 70 adults (26–29, 45.7% female), who did not regularly use cannabis when they were under age 18, and n = 76 adolescents (16–17, 50.0% female). The exposure was adolescent (compared to adult) frequent cannabis use. The primary outcome was CUD symptoms measured using the cannabis use disorder identification test revised (CUDIT-R) at five time points. Models were adjusted for cannabis quantity using mean weekly standard THC units (one unit = 5 mg THC). Other covariates included gender, and whether each session occurred before or during the COVID-19 pandemic. In models adjusted for pre-registered covariates, adolescents scored 3.7 points higher on the CUDIT-R compared to the adult group across the 5 assessment waves (3.66 95% CIs 1.99, 5.34). There was also evidence of a linear reduction in symptoms over time in both groups (−0.47, 95%CIs −0.67, −0.27). Adolescents had persistently increased CUD symptoms compared to adults across the 12-month period. This association was robust after adjusting for the quantity of cannabis consumed and other covariates.
Intraday repeatability of macular layers measurements in glaucomatous and non-glaucomatous patients using spectral-domain optical coherence tomography
Authors: Makhmutov Vadim , Adler Werner , Matos Philomena A. Wawer , Kopecky Adam , Nemcansky Jan , Rokohl Alexander C. , Heindl Ludwig M. 
Published: May 2024

Abstract
Purpose
To assess the intraday repeatability of macular architecture measurements in glaucomatous and non-glaucomatous patients using spectral-domain optical coherence tomography (SD-OCT) and to evaluate the independence from intraindividual intraocular pressure (IOP) fluctuations.

Methods
In this single-center, time-point comparison study, 88 eyes with glaucoma, 53 eyes with ocular hypertension (OHT), and 253 healthy eyes underwent two standardized SD-OCT and intraocular pressure (IOP) measurements on the same day with a 5-h time gap. Bland–Altman plots, intraclass correlation coefficients (ICC), and random-effects model were used to analyze repeatability of entire retinal thickness, retinal nerve fiber layer, ganglion cell layer, inner plexiform layer, and inner nuclear layer measurements.

Results
Intraday measurements were highly reproducible in all 3 groups. ICC were greater than 0.90, respectively. The pairwise comparisons of morphometric parameters showed a statistically significant difference (P < 0.001, respectively) between groups (glaucoma vs. control, glaucoma vs. OHT) and a significant influence of time points. No correlation was found between IOP fluctuations and morphometric parameters (P > 0.05, respectively), except for a weak positive correlation with GCL (rho = 0.109, P = 0.031).

Conclusions
The evaluation of macular morphometric parameters of SD-OCT showed a high intraday repeatability and an excellent degree of agreement in glaucoma, ocular hypertension, and healthy groups. The fixed effects of time points were statistically significant. Except for a weak positive correlation of ganglion cell layer, variability did not appear to be affected by intraday IOP changes. Additional research is required to fully understand the impact of IOP fluctuations on macular morphometric parameters, considering the small observed IOP changes.
Expression patterns of HNF4α, TTF-1, and SMARCA4 in lung adenocarcinomas: impacts on clinicopathological and genetic features
Authors: Kawai Hitomi , Miura Tamaki , Kawamatsu Natsumi , Nakagawa Tomoki , Shiba-Ishii Aya , Yoshimoto Taichiro , Amano Yusuke , Kihara Atsushi , Sakuma Yuji , Fujita Kazutaka , Shibano Tomoki , Ishikawa Shumpei , Ushiku Tetsuo , Fukayama Masashi , Tsubochi Hiroyoshi , Endo Shunsuke , Hagiwara Koichi , Matsubara Daisuke , Niki Toshiro 
Published: May 2024

Abstract
Introduction
HNF4α expression and SMARCA4 loss were thought to be features of non-terminal respiratory unit (TRU)-type lung adenocarcinomas, but their relationships remained unclear.

Materials and methods
HNF4α-positive cases among 241 lung adenocarcinomas were stratified based on TTF-1 and SMARCA4 expressions, histological subtypes, and driver mutations. Immunohistochemical analysis was performed using xenograft tumors of lung adenocarcinoma cell lines with high HNF4A expression.

Result
HNF4α-positive adenocarcinomas(n = 33) were divided into two groups: the variant group(15 mucinous, 2 enteric, and 1 colloid), where SMARCA4 was retained in all cases, and the conventional non-mucinous group(6 papillary, 5 solid, and 4 acinar), where SMARCA4 was lost in 3/15 cases(20%). All variant cases were negative for TTF-1 and showed wild-type EGFR and frequent KRAS mutations(10/18, 56%). The non-mucinous group was further divided into two groups: TRU-type(n = 7), which was positive for TTF-1 and showed predominantly papillary histology(6/7, 86%) and EGFR mutations(3/7, 43%), and non-TRU-type(n = 8), which was negative for TTF-1, showed frequent loss of SMARCA4(2/8, 25%) and predominantly solid histology(4/8, 50%), and never harbored EGFR mutations. Survival analysis of 230 cases based on histological grading and HNF4α expression revealed that HNF4α-positive poorly differentiated (grade 3) adenocarcinoma showed the worst prognosis. Among 39 cell lines, A549 showed the highest level of HNF4A, immunohistochemically HNF4α expression positive and SMARCA4 lost, and exhibited non-mucinous, high-grade morphology in xenograft tumors.

Conclusion
HNF4α-positive non-mucinous adenocarcinomas included TRU-type and non-TRU-type cases; the latter tended to exhibit the high-grade phenotype with frequent loss of SMARCA4, and A549 was a representative cell line.
Exploring the Triplet State of Chlorophyll a in Mesoporous Silica Matrices by Time-Resolved EPR
Authors: Zatta Samuel , Calcinoni Andrea , Agostini Alessandro , Leccese Silvia , Onfroy Thomas , Jolivalt Claude , Mezzetti Alberto , Bortolus Marco , Carbonera Donatella 
Published: May 2024

AbstractChlorophyll is a pivotal molecule in photosynthesis due to its ability to absorb solar light and start the photochemical process. The chlorophyll triplet state is easily populated from the light-induced singlet excited state via Intersystem Crossing (ISC) and can react with oxygen generating singlet oxygen, posing a threat to the stability of chlorophyll, but also an opportunity for photodynamic therapy. Here, we focus on the study of the photo-physical properties of chlorophyll a and WSCP (Water-Soluble Chlorophyll Protein, a protein binding the pigment), which have been adsorbed in mesoporous silica matrices. We adopt SBA-15, a silica matrix with well-ordered hexagonal structure with pores of 70 Å of diameter. The triplet formed upon illumination in these systems is studied by time-resolved EPR spectroscopy. Analysis of the EPR spectra shows that the triplet state is very sensitive to the inclusion in the pores of SBA-15 modifying its spin polarization. Chl a in SBA-15 loses its central metal ion, while its structure remains unchanged if the mesoporous silica is previously soaked into a basic solution before Chl a adsorption, as revealed by its zero-field splitting parameters of the triplet state. WSCP is readily included in the silica matrix, but its embedded pigments are no longer protected by the protein core.
Predicting Airbnb pricing: a comparative analysis of artificial intelligence and traditional approaches
Authors: Camatti Nicola , di Tollo Giacomo , Filograsso Gianni , Ghilardi Sara 
Published: May 2024

AbstractAirbnb's distinctive model accommodates a broad spectrum of hosts, ranging from non-professionals to traditional establishments, resulting in a nuanced pricing system that poses challenges for prediction. This paper delves into Airbnb pricing and, to address this exercise, introduces computational approaches that combine traditional linear methods and advanced artificial intelligence techniques. Utilizing real data from the Netherlands, the study specifically focuses on all active Airbnb listings until September 2019. Our contribution stands out by incorporating the financial history of diverse rental offerings, a novel aspect compared to existing literature. Unlike other studies, our investigation spans various cities in the Netherlands, providing a comprehensive view beyond individual regions. Our results highlight the robust predictive capabilities of Artificial Intelligence techniques, that lead to lower susceptibility to overfitting and to superior overall performances. However, traditional methods also prove to be valuable, aiding in determining the significance of predictors in the predicting exercise. Collectively, these approaches offer valuable insights to enhance pricing strategies and overall performances within the Airbnb market.
Clinical and molecular predictors of very late recurrence in oestrogen receptor-positive breast cancer patients
Authors: Richman Juliet , Schuster Gene , Buus Richard , Lopez-Knowles Elena , Dowsett Mitch 
Published: May 2024

Abstract
Background
Risk of recurrence from primary ER+ breast cancer continues for at least 20 years. We aimed to identify clinical and molecular features associated with risk of recurrence after 10 years.

Methods
ER+ breast cancers from patients with and without recurrence were analysed with the BC360 NanoString Panel and an 87 gene targeted-exome panel. Frequency of clinical, pathologic and molecular characteristics was compared between cases (recurred between 10 and 20 years) and controls (no recurrence by 20 years) in the Very Late Recurrence (VLR) cohort. Analogous data from METABRIC were examined to confirm or refute findings.

Results
VLR cases had larger tumours and higher node positivity. Both VLR and METABRIC cases had higher clinical treatment score at 5 years (CTS5). There was a trend for fewer GATA3 mutations in cases in both VLR and METABRIC but no statistically significant differences in mutation frequency. Cell cycle and proliferation genes were strongly expressed in VLR cases. Immune-related genes and cell cycle inhibitors were highly expressed in controls. Neither of these changes were significant after correction for multiple testing.

Conclusions
Clinicopathologic features are prognostic beyond 10 years. Conversely, molecular features, such as copy number alterations, TP53 mutations and intrinsic subtype which have early prognostic significance, have little prognostic value after 10 years.
Effectiveness of gonadotropin-releasing hormone agonists for ovarian function suppression in premenopausal patients with hormone receptor-positive breast cancer: a retrospective single-center real-world study
Authors: Chen Yifei , Zhang Ruyan , Yan Ying , Li Huiping , Song Guohong 
Published: May 2024

Abstract
Purpose
This study evaluated the effectiveness of ovarian function suppression (OFS) of various gonadotropin-releasing hormone agonists (GnRHa) combined with aromatase inhibitors (AI) in premenopausal patients with hormone receptor-positive (HR-positive) breast cancer. Potential risk factors associated with insufficient OFS were analyzed.

Patients and methods
Premenopausal HR-positive breast cancer patients who had received AI with GnRHa were studied retrospectively. Patients were divided into different groups according to monthly or trimonthly GnRHa schedules they received, and the effectiveness of OFS was compared between groups. Insufficient OFS was defined as at least one instance of estradiol ≥ 30 pg/ml. Patient data was gathered from medical records for this comparison.

Results
Of the 264 patients enrolled in this study, 117 were administered 3.6 mg of goserelin monthly (goserelin 1 M group), 63 received 3.75 mg of leuprorelin monthly (leuprorelin 1 M group) and 84 were given 11.25 mg of leuprorelin every three months (leuprorelin 3 M group). Overall, 7.20% experienced insufficient OFS. The incidence rates in the three GnRHa depot groups were 7.69%, 6.35%, and 7.14%, respectively, without a significant statistical difference (P = 0.900). Notably, younger patients exhibited a higher likelihood of insufficient OFS [OR = 0.900, 95%CI (0.824–0.982), P = 0.018].

Conclusion
Insufficient OFS remains a concern during GnRHa and AI treatment. The effectiveness of the three GnRHa depots commonly used in China seems comparable. Younger patients face a heightened risk of insufficient OFS.
A ‘greenhouse affect’? Exploring young Australians’ emotional responses to climate change
Authors: Russell Tanja 
Published: May 2024

AbstractRecent studies reveal that young people are experiencing a range of emotions relating to climate change, including anxiety, anger and a sense of powerlessness. Young people have also voiced distrust in governments for failing to adequately address climate change, which they see as a critical threat to their future. However, there is limited research considering the interplay between young people’s emotions about climate change and the broader social context in which they live; social-ecological theory can assist in identifying important systemic factors influencing emotional responses to climate change. In this qualitative research project, I drew upon a social-ecological theoretical framework to explore the affective dimensions of climate change as experienced by young Australians aged 18–24 (N = 14). A primary, overarching finding was of climate change as a multidimensional emotional challenge for young people, with four sub-themes that describe key experiences through which it manifests: a fragmented climate education; disillusionment with politics, but hope for change; reckoning with uncertain futures; and grappling with agency. The findings contribute to the growing literature on climate-related emotions, highlighting experiences of interrelated emotions that resist being reduced to one label (e.g., ‘eco-anxiety’). Accordingly, I discuss a ‘greenhouse affect’ to convey the affective quandary provoked by climate change, expanding upon established anxiety-centred concepts. I also discuss implications for educating young Australians about climate change, and how this might improve their sense of agency to meaningfully contribute to climate solutions.