bluuebunny/crossref_metadata_2025_split huggingface dataset:
Signal setting with demand assignment: global optimization with day‐to‐day dynamic stability constraints
Authors: Cantarella Giulio Erberto , Velonà Pietro , Vitetta Antonino 
Published: March 2012

SUMMARYThis paper deals with traffic signal setting with demand assignment. All approaches proposed in literature to address this problem are based on equilibrium assignment, well established in literature as well as in practice. Still, it is widely acknowledged that there are some relevant issues that may not be effectively addressed under the equilibrium approach, mainly uniqueness and stability, sensitivity to parameters and/or starting state. These issues should be better dealt with a day‐to‐day dynamic approach, through deterministic (or stochastic) process models. This issue seems relevant because optimization of signal timings under equilibrium assumptions may not guarantee that an effective solution is obtained, because it may well be not an attractor of the evolution over time.The main contributions of this paper are as follows:

A simple but still effective deterministic process models based on exponential smoothing filters, which also include effects of signal setting, this model allows to state local stability of fixed‐point states (consistent with equilibrium patterns) through the spectral analysis of the Jacobian matrix of the recursive equations modelling the evolution over time of the system.
An expression of equilibrium stability conditions that can be included as constraints within global optimization models for signal setting; such models guarantee that stability conditions are satisfied by obtained solution.Results from an application to a toy network, supporting major theoretical findings, are also reported. The very simple example allows for graphical representation to develop a general method useful to address implementation at real scale. Copyright © 2012 John Wiley & Sons, Ltd.
Simultaneous determination of atorvastatin and niacin in human plasma by LC‐MS/MS and its application to a human pharmacokinetic study
Authors: Ravi Vasu Babu , Mullangi Ramesh , Inamadugu Jaswanth Kumar , Pilli Nageswara Rao , Gajula Ramakrishna , Ponneri Venkateswarlu 
Published: March 2012

ABSTRACTA rapid, simple, sensitive and selective LC‐MS/MS method has been developed and validated for quantification of the atorvastatin (AT) and niacin (NA) in 250 μL human plasma. The analytical procedure involves a liquid–liquid extraction method using nevirapine as an internal standard (IS). The chromatographic separation was achieved on a Hypurity Advance (4.6 × 50 mm, 5 µm) column using a mobile phase consisting of 0.1% formic acid buffer–acetonitrile (20:80, v/v) at flow rate of 0.8 mL/min. The API‐4000 LC‐MS/MS was operated in the multiple‐reaction monitoring mode using electrospray ionization. The total run time of analysis was 3 min and elution of AT, NA and IS occurred at 1.06, 1.84 and 0.92 min, respectively. A detailed validation of the method was performed as per the US Food and Drug Administration guidelines and the standard curves found to be linear in the range of 0.10–30.0 ng/mL for AT and 20.2–6026 ng/mL for NA, with a coefficient of correlation of ≥0.99 for both the compounds. AT and NA were found to be stable in a battery of stability studies, viz. bench‐top, autosampler, re‐injection, wet‐extract and repeated freeze–thaw cycles. The developed assay method was successfully applied to a pharmacokinetic study in humans. Copyright © 2012 John Wiley & Sons, Ltd.
Rapid‐exchange guide catheter extension for extending the reach of an AL3 guide in a patient with a long, dilated ascending aorta
Authors: Roth Gregory A. , Dean Larry S. , Don Creighton W. 
Published: March 2012

AbstractWe describe the use of a rapid‐exchange style guide catheter extension to facilitate diagnostic coronary angiography in a patient with a long, dilated ascending aorta. The guide catheter extension is an easy to use device that can extend the reach of 110 cm catheters. There are several advantages to this “mother and child” guide catheter extension over the traditional telescoping catheter approach. © 2012 Wiley Periodicals, Inc.
Angiographic investigation of the pathophysiology of perioperative myocardial infarction
Authors: Duvall W. Lane , Sealove Brett , Pungoti Chetan , Katz Daniel , Moreno Pedro , Kim Michael 
Published: March 2012

AbstractBackground: The study of the pathophysiologic mechanism of perioperative myocardial infarctions is limited to two small autopsy studies suggesting a major role for plaque rupture and thrombosis. However, the perioperative period is characterized by increased cardiac metabolic demand that may lead to infarction in patients with otherwise stable obstructive coronary artery disease. The purpose of this study is to investigate the pathophysiology of perioperative myocardial infarctions. Methods: Hospital records and coronary angiograms from patients from 1998 to 2006 who underwent noncardiac surgery complicated by a perioperative myocardial infarction (MI) were reviewed. The culprit lesion was identified based on ECG, left ventriculography, and coronary angiography. Degree of stenosis, TIMI flow, ACC thrombus grade, calcification score, and lesion morphology were evaluated. Based on these criteria, MIs were categorized as thrombotic, demand, or nonobstructive. Results: Sixty‐six patients (average age, 71 years and 44% male), 77% of whom underwent an intermediate risk surgery with a 2% perioperative mortality, were identified. The distribution of demand, thrombotic, and nonobstructive MI was 55%, 26%, and 19%, respectively. There was neither statistical difference in the occurrence of prolonged hypotension or tachycardia between groups nor was there any difference in the use of antiplatelets, β‐blockers, or statins. Conclusion: This study identified demand ischemia as the predominant etiology of perioperative MIs in this cohort. An improved understanding of the pathophysiologic mechanism of perioperative MIs may facilitate the evaluation and management of preoperative patients. © 2012 Wiley Periodicals, Inc.
Impact of three‐dimensional transesophageal echocardiography on prosthesis sizing for transcatheter aortic valve implantation
Authors: Husser Oliver , Rauch Simon , Endemann Dierk H. , Resch Markus , Nunez Julio , Bodi Vicente , Hilker Michael , Schmid Christof , Riegger Günter A.J. , Luchner Andreas , Hengstenberg Christian 
Published: March 2012

AbstractObjectives: To compare aortic annulus diameters obtained by 3D transesophageal echocardiography (TEE) with 2D‐TEE and the impact on prosthesis size selection in transcatheter aortic valve implantation (TAVI). Background: In TAVI the aortic annulus diameter determines prosthesis size. The ideal modality for annulus assessment has not been defined yet. Methods: Annulus diameters in 2D‐TEE (long‐axis view) and in 3D‐TEE (long‐axis view in multiple‐plane‐reconstruction) were compared in consecutive patients with aortic stenosis screened for TAVI. Prosthesis size was selected according to industry guidelines, integrating data from 3D‐TEE, angiography and computed tomography. The percentage of cases in which 2D‐TEE and 3D‐TEE correctly predicted final prosthesis size was calculated. Results: Forty‐nine patients were studied (Age 80 ± 5, 39% male, logistic EuroScore 17 ± 11%). Annulus diameters from 2D‐ and 3D‐TEE correlated (r = 0.808, P < 0.0001). Mean diameters were significantly larger on 3D‐ vs. 2D‐TEE (23.4 ± 2.2 vs. 22.1 ± 2.6 mm, P < 0.001) with a mean difference of 1.2 mm (limits of agreement: −1.8 to 4.3). The interobserver variability of 2D‐ and 3D‐TEE was 3.5 ± 5.6% and 0.9 ± 5.1%, respectively. Thirty‐nine patients underwent TAVI (27 CoreValve™, 12 Edwards Sapien™). The procedure was successful in 37 (95%) patients. Postprocedural regurgitation was none or mild in 89% of the cases with no severe insufficiency. Final prosthesis size was correctly predicted by 2D‐TEE in 67% while in 80% by 3D‐TEE. Overall, 3D‐TEE suggested a different prosthesis size in 26% of all cases compared to 2D‐TEE. Conclusions: Aortic annulus measurement by 3D‐TEE yields significantly larger diameters than 2D‐TEE. This impacts prosthesis size selection in a considerable percentage of cases. © 2012 Wiley Periodicals, Inc.
Chronic kidney disease and the risk of stent thrombosis after percutaneous coronary intervention with drug‐eluting stents
Authors: Miao Yu , Yu‐Jie Zhou , Zhi‐Jian Wang , Dong‐Mei Shi , Yu‐Yang Liu , Ying‐Xin Zhao , Fei Gao , Shi‐Wei Yang , De‐An Jia 
Published: March 2012

AbstractBackgroundChronic kidney disease (CKD) has been demonstrated to be associated with adverse clinical outcomes for patients with coronary artery disease (CAD). However, data on relation of CKD and stent thrombosis (ST) after drug‐eluting stent (DES) implantation are limited.ObjectivesThis study was designed to examine whether CKD is associated with higher incidence of ST after elective coronary DES implantation compared with patients with normal renal function.MethodsWe consecutively enrolled 2,862 patients undergoing elective percutaneous coronary intervention (PCI) with DES. Demographic and clinical data were collected preoperatively. CKD was defined as estimated glomerular filtration rate (eGFR) < 60 ml/min, calculated using the modified MDRD equation. The primary outcome was 1‐year definite or probable ST.ResultsFour hundred and forty‐five participants (15.5%) had CKD before procedure. The incidence of 1‐year definite or probable ST was significantly higher in CKD patients compared with patients with normal renal function (1.8% vs. 0.6%, P = 0.014). After adjustment for multiple clinical and biochemical covariates, CKD was an independent predictor of 1‐year definite or probable ST (hazard rate [HR] 0.396, 95% CI 0.165–0.951, P = 0.038).ConclusionCKD is significantly associated with increased incidence of 1‐year definite or probable ST in patients undergoing PCI with DES. © 2012 Wiley Periodicals Inc.
Magnetic Nanoparticles of Ferrite Complex Oxides: A Cheap, Efficient, Recyclable Catalyst for Building the CN Bond under Ligand‐Free Conditions
Authors: Zhang Rongzhao , Miao Chengxia , Shen Zhiqiang , Wang Shoufeng , Xia Chungu , Sun Wei 
Published: March 2012

AbstractA series of magnetic nanoparticles of ferrite complex oxides were simply prepared by using a citric acid complex method and characterized by using XRD, FT‐IR spectroscopy, TEM, the BET nitrogen adsorption/desorption technique, and a vibrating sample magnetometer. The magnetic nanoparticles were used for the N‐arylation of nitrogen nucleophiles to form new CN bonds. CuFe2O4 nanoparticles calcined at 850 °C exhibited the best activity with moderate to excellent yields under ligand‐free conditions. Notably, CuFe2O4 is completely recoverable with an external magnet and can be reused eight times without significant loss of catalytic activity.
Kinetic Study of Spent Nickel Catalyst Dissolution in HCl and Aqua Regia Medium
Authors: Hosseini S. A. , Khalilzadeh M. A. , Jamshidi A. 
Published: March 2012

AbstractThe leaching kinetics of spent nickel oxide catalysts in HCl and aqua regia solution is described. The considered parameters affecting nickel recovery are particle size, reaction time, acid concentration, and reaction temperature. Nickel could be extracted with HCl by ∼87.41 % and with aqua regia by ∼81.01 % using a spent catalyst with 200 mesh particle size at a reaction temperature of 100 °C. The reaction time was 360 min and the concentrations of HCl and aqua regia were 37 % and 80 %, respectively. The leaching kinetics indicates that shrinking sphere and diffusion were the rate‐controlling processes during the reactions with HCl and aqua regia, respectively. The activation energies for HCl and aqua regia were determined as 24.04 and 19.03 kJ mol–1, respectively.
Experimental and Kinetic Studies on a Homogeneous System for Diethyl Carbonate Synthesis by Transesterification
Authors: Zhang Y. , Ji Z. , Xu R. , Fang Y. 
Published: March 2012

AbstractA synthesis of diethyl carbonate through transesterification of propylene carbonate and ethanol, coproducing useful propylene glycol, was carried out in the presence of sodium ethoxide as catalyst. The effects of reaction parameters such as catalyst concentration, mole ratio of ethanol to propylene carbonate and reaction temperature on the transesterfication reaction were investigated. The results showed that the reaction is reversible with a propylene carbonate equilibrium conversion of about 64 % at an ethanol to propylene carbonate mole ratio of 8.0 and a reaction temperature of 303 K. A kinetic model was proposed based on the reaction mechanism. The model parameters were estimated by the Runge‐Kutta method. The statistical test showed that the model calculation results were in good agreement with the experimental data.
Online Monitoring of Vinyl Chloride Polymerization in a Microreactor Using Raman Spectroscopy
Authors: Dorobantu Bodoc M. , Prat L. , Xuereb C. , Gourdon C. , Lasuye T. 
Published: March 2012

AbstractA novel capillary‐based microfluidic device has been designed to follow the vinyl chloride polymerization reaction. Monodisperse droplets of 200 μm diameter could be obtained by means of a co‐flow generation system, each one being considered as a polymerization reactor. Monomer droplets were visualized in a microchannel with a high‐speed camera. At the end of the reaction, PVC grains were observed with a scanning electron microscopy technique. Real‐time non‐invasive Raman measurement was performed on stationary vinyl chloride monomer droplets and provided values of effective reaction orders and rate constants. This microdevice allowed reaction investigation under difficult conditions of pressure and temperature with a minimal amount of reagents.
Nitrogen‐Doped Carbon Monolith for Alkaline Supercapacitors and Understanding Nitrogen‐Induced Redox Transitions
Authors: Wang Da‐Wei , Li Feng , Yin Li‐Chang , Lu Xu , Chen Zhi‐Gang , Gentle Ian R. , Lu Gao Qing (Max) , Cheng Hui‐Ming 
Published: March 2012

AbstractA nitrogen‐doped porous carbon monolith was synthesized as a pseudo‐capacitive electrode for use in alkaline supercapacitors. Ammonia‐assisted carbonization was used to dope the surface with nitrogen heteroatoms in a way that replaced carbon atoms but kept the oxygen content constant. Ammonia treatment expanded the micropore size‐distributions and increased the specific surface area from 383 m2 g−1 to 679 m2 g−1. The nitrogen‐containing porous carbon material showed a higher capacitance (246 F g−1) in comparison with the nitrogen‐free one (186 F g−1). Ex situ electrochemical spectroscopy was used to investigate the evolution of the nitrogen‐containing functional groups on the surface of the N‐doped carbon electrodes in a three‐electrode cell. In addition, first‐principles calculations were explored regarding the electronic structures of different nitrogen groups to determine their relative redox potentials. We proposed possible redox reaction pathways based on the calculated redox affinity of different groups and surface analysis, which involved the reversible attachment/detachment of hydroxy groups between pyridone and pyridine. The oxidation of nitrogen atoms in pyridine was also suggested as a possible reaction pathway.
ChemInform Abstract: Highly Enantioselective Michael Addition of Ketones to Nitroolefins with a Pyrrolidine‐Based Phthalimide as an Enamine‐Type Organocatalyst.
Authors: Ban Shu‐rong , Xie Hong‐yu , Zhu Xi‐xia , Li Qing‐shan 
Published: March 2012

AbstractA new N‐(pyrrolidinylmethyl)phthalimide organocatalyst is successfully applied in the Michael addition reaction of nitroolefins towards cyclohexanone (I).
ChemInform Abstract: Co(I)‐ versus Ru(II)‐Catalyzed [2 + 2 + 2] Cycloadditions Involving Alkynyl Halides.
Authors: Iannazzo Laura , Kotera Naoko , Malacria Max , Aubert Corinne , Gandon Vincent 
Published: March 2012

AbstractWhile Ru catalysts remain the best choice for [2 + 2 + 2] cycloaddition reactions of alkynyl chlorides and iodides, the cheap air‐stable cobalt complex under certain conditions proves efficient with alkynyl bromides.
ChemInform Abstract: N‐Heterocyclic Carbene Based Ruthenium‐Catalyzed Direct Amide Synthesis from Alcohols and Secondary Amines: Involvement of Esters.
Authors: Chen Cheng , Zhang Yao , Hong Soon Hyeok 
Published: March 2012

AbstractThe Ru‐complex in combination with KOtBu efficiently promotes the coupling of alcohols with secondary amines.
ChemInform Abstract: First Nucleophilic Addition of Acetylide to 1,3‐Diketonate Anions: Reaction of 1‐Aryl‐4,4,4‐trifluorobutane‐1,3‐diones with Sodium Acetylide.
Authors: Usachev Boris I. 
Published: March 2012

AbstractRegioselective nucleophilic addition affords alkyne diols (III) which are converted into bisfurans (IV) via a novel double cyclization.
ChemInform Abstract: Palladium‐Catalyzed C—C Bond Formation of Arylhydrazines with Olefins via Carbon—Nitrogen Bond Cleavage.
Authors: Zhu Ming‐Kui , Zhao Jun‐Feng , Loh Teck‐Peng 
Published: March 2012

AbstractThe unactivated C—N bond of various aryl hydrazines (I), (IV), (VII), and (X) is cleaved under mild conditions by Pd(0) with the assistance of Pd(II).
ChemInform Abstract: Synthesis of Biaryls via AlCl3 Catalyzed Domino Reaction Involving Cyclization, Dehydration, and Oxidation.
Authors: Narender Tardigoppula , Sarkar Satinath , Rajendar Kandikonda , Tiwari Sriniwas 
Published: March 2012

AbstractA novel method for the synthesis of biaryls (IV) and (VII) is elaborated using a prenylation reaction of aromatic ketones (I) and (V) and a subsequent AlCl3‐catalyzed domino reaction of resulting prenylated ketones (III) and (VI) respectively.
ChemInform Abstract: Catalytic Asymmetric Construction of Spirocyclopentaneoxindoles by a Combined Ru‐Catalyzed Cross‐Metathesis/Double Michael Addition Sequence.
Authors: Li Ying‐Mei , Li Xiang , Peng Fang‐Zhi , Li Ze‐Qian , Wu Shou‐Tao , Sun Zhong‐Wen , Zhang Hong‐Bin , Shao Zhi‐Hui 
Published: March 2012

AbstractThe ruthenium‐catalyzed cross‐metathesis of 3‐allyloxindoles (I) with ethyl acrylate followed by an asymmetric double‐Michael addition reaction of resulting oxindoles (III) with nitroolefins (IV) provides access to spirocyclopentaneoxindoles (V) with high diastereo‐ and enantioselectivity.
ChemInform Abstract: An Efficient and Convenient Approach for the Synthesis of Novel 2‐Hydroxy‐12‐aryl‐8,9,10,12‐tetrahydrobenzo[a]xanthene‐11‐ones Using p‐Toluenesulfonic Acid in Ethanol and Ionic Liquid.
Authors: Khurana Jitender M. , Nand Bhaskara , Sneha Sneha 
Published: March 2012

AbstractThe presented method is operationally convenient, gives excellent yields of the title compounds in high purity with easy work‐up.
ChemInform Abstract: New Spirocyclic Δ2‐Isoxazoline Derivatives Related to Selective Agonists of α7 Neuronal Nicotinic Acetylcholine Receptor.
Authors: Dallanoce Clelia , et al. et al. 
Published: March 2012

AbstractCompounds (VI) and (XIV) exhibit an equal binding affinity in the nanomolar range at the α7 nAChRs as the reference compounds.
Methodical Approaches to Experimental Investigations on Surface Filtration using Flexible Filter Media on a Standard Laboratory Filter Test Rig
Authors: Zhang Qian , Schmidt Eberhard 
Published: March 2012

AbstractDie Partikelabscheidung aus Gasen mit Oberflächenfiltern ist sowohl bei der Emissionsminderung als auch bei der Wertstoffgewinnung ein bewährtes Standardverfahren. Experimentelle Untersuchungen zur Oberflächenfiltration werden häufig mit Testfiltern, die an Filteranlagen im Labormaßstab eingebaut sind, durchgeführt. Am Beispiel einer bekannten genormten Labor‐Filterprüfapparatur werden Ansatzpunkte zum methodischen Vorgehen bei experimentellen Untersuchungen zur Oberflächenfiltration mit flexiblen Filtermedien beschrieben und diskutiert, die einen schlüssigen quantitativen Vergleich der experimentellen Ergebnisse ermöglichen bzw. erleichtern sollen.
Impact of density gradients on the fluid flow inside a vibrating cavity subjected to soret effect
Authors: Parsa Aram , Srinivasan Seshasai , Saghir M. Ziad 
Published: March 2012

AbstractComputational fluid dynamics simulations of thermovibrational flows in a square cavity filled with a water–isopropanol mixture has shown that inaccurate density calculations can predict very different flow behaviours. Specifically, comparison has been made between two density calculation models, viz., a weighted‐average scheme and the Perturbed Chain Statistical Associating Fluid Theory equation of state. While the latter approach predicts a stronger flow in the cavity due to the convective instabilities that are induced by the large spatial gradients in density, the weighted‐average scheme cannot predict this since it does not explicitly depend on the temperature of the mixture. © 2012 Canadian Society for Chemical Engineering
The Binding of a Hydroxy‐9,10‐anthraquinone CuII Complex to Calf Thymus DNA: Electrochemistry and UV/Vis Spectroscopy
Authors: Guin Partha S. , Mandal Parikshit C. , Das Saurabh 
Published: March 2012

AbstractAnthracyclines are broad‐spectrum antibiotics that are used against several human cancers. Hydroxy‐9,10‐anthraquinone compounds closely resemble anthracycline antibiotics from a structural and functional viewpoint. High cost and aspects of toxicity introduce limitations on its use. On complex formation the toxicities of anthracyclines decrease. A close analogue is sodium 1,4‐dihydroxy‐9,10‐anthraquinone‐2‐sulphonate (AS), which is a comparatively cheaper molecule and resembles a good number of anthracycline derivatives. It forms a complex with CuII, [Cu(AS)2]. The complex interacts with calf thymus DNA that was studied by UV/Vis spectroscopy and cyclic voltammetry. The experimental data obtained from the two techniques was analyzed for binding constant and size of the binding site. These results not only corroborate each other but also justify earlier data obtained using fluorescence spectroscopy. An important aspect to this study was that nonlinear curve fitting, which is usually applied for analyzing DNA interaction using fluorescence and absorption spectroscopy, was used for the first time to analyze the interaction of the complex with DNA using cyclic voltammetry by monitoring the change in the reduction peak current (Ip). The DNA binding data provides an insight into a probable mode of action of the hydroxy‐9,10‐anthraquinones within cells as modification of DNA that leads to cell death is an important aspect in cancer research.
An indicator kriging method for distributed estimation in wireless sensor networks
Authors: Liu Guiyun , Xu Bugong , Chen Hongbin 
Published: March 2012

SUMMARYThe problem of distributed estimation in a wireless sensor network with unknown observation noise distribution is investigated, where each sensor only sends quantized data to a fusion center. The sensing field is modeled as a spatially random field. The objective was to accurately estimate a hidden parameter at the location where no sensor exists, while minimizing the total energy consumption. Driven by the lack of a prior knowledge of the sensing field and the existence of some outliers, an indicator kriging estimator is developed for distributed estimation under imperfect communication channels between the sensors and the fusion center. The tradeoff between estimation performance and energy consumption is formulated as an optimization problem, and a global search algorithm is proposed to approximate the solution. The results show that the proposed indicator kriging estimator achieves better performance than the inverse distance estimator and the simple averaging estimator. Moreover, the proposed search algorithm can schedule the sensors to reach the tradeoff. Copyright © 2012 John Wiley & Sons, Ltd.