bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Assessment of Invitro Anti-Alzheimer Activity of Ammania Bacciferra Linn.
Authors: Maskwade Rahul , Daniel Kratika , Jain Sachin K , Vengurlekar Sudha 
Published: May 2024

Neurodegenerative disorders are characterized by the progressive and irreversible loss of neurons from specific brain areas. Alzheimer's disease (AD), where loss of hippocampal and cortical neurons impairs memory and cognitive function. From the literature review it was revealed that Ammania bacciferra linn. possess good antioxidant activity because of its active constituents and anti-oxidant may treat some neurodegenerative disorders. The main objective of this work is to identify the Alzheimer activity of Ammania bacciferra linn. Invitro activity was performed by Ellman method and IC50 Value was found to be 315 µg/mL Further extract was subjected for in vivo activity.
Keywords: Neurodegenerative disorders, neurons, Alzheimer's diseases. Memory enhancer.
Pemodelan Regresi Semiparametrik Spline pada Persentase Penduduk Miskin di Provinsi Kalimantan Selatan
Authors: Muhammad Munawwir  , Farid Fuad Muhajirin , Rahkmawati Yeni 
Published: May 2024

Kemiskinan merupakan salah satu tantangan pembangunan yang belum terselesaikan di seluruh dunia, termasuk Indonesia. Salah satu wilayah di Indonesia yang persentase penduduk miskinnya berada di bawah tingkat persentase penduduk miskin secara nasional adalah Provinsi Kalimantan Selatan. Persentase penduduk miskin di Kalimantan Selatan dari Tahun 2000 hingga Maret 2022 selalu berada di bawah tingkat nasional. Perekonomian di Kalimantan Selatan didominasi oleh sektor pertambangan dan penggalian yang kurang berkelanjutan sehingga memungkinkan persentase penduduk miskin di Kalimantan Selatan rentan mengalami kenaikan. Oleh sebab itu, pemodelan persentase penduduk miskin serta variabel lain yang diamati perlu dilakukan. Penelitian ini bertujuan untuk menjelaskan bagaimana pemodelan persentase penduduk miskin berdasarkan variabel yang diamati diasumsikan mempengaruhinya. Untuk mencapai tujuan tersebut, teknik yang diterapkan dalam memodelkan persentase penduduk miskin adalah regresi semiparametrik spline. Hasil dari penggunaan regresi spline semiparametrik ini didapatkan bahwa parameter model tidak signifikan sehingga membutuhkan pemodelan terpisah untuk regresi parametrik dan nonparametrik. Berdasarkan pemisahan model tersebut didapatkan bahwa menggunakan regresi linier berganda terdapat 2 variabel prediktor yang berpengaruh, yaitu pengeluaran per kapita yang disesuaikan dan persentase rumah tangga yang menggunakan air layak.
Traffic Characteristics on Soekarno Hatta Road After the Operation of Kopo Flyover, Bandung City
Authors: Akbardin Juang , Kurnia Mulyawanti Widia , Mohamad Ma’soem Dadang 
Published: May 2024

Bandung is one of the major cities in Indonesia located in West Java Province. One of the roads that is often traveled by vehicles in Bandung is Soekarno Hatta road, which is the longest road in Bandung that cuts from Cibiru to Sudirman road. The emergence of congestion on the Soekarno Hatta road in Bandung City is a problem that is often faced by motorists. This is caused by excessive mobility and declining road facilities. The purpose of this study is to analyze the characteristics of traffic flow on Soekarno Hatta Road after the operation of Kopo Flyover, precisely above and below Kopo Flyover, Bandung City. From the results of data analysis, it can be seen that the largest vehicle volume occurred at Point III on Thursday which amounted to 10954.40 skr/hour, the largest speed occurred at Point I on Sunday at 59.10 km/hour and the densest density occurred at Point III on Tuesday at 306.69 skr/km. Traffic performance in terms of degree of saturation (D), at Point I obtained 0.90926 has level of service E, at Point II obtained 0.71992 has level of service C and at Point III obtained 0.93963 has level of service E.
Role Of Youth Information Centers And Counseling In Minimizing Premature Wedding Events
Authors: Putri Hernisa Trisna , Yuliana Fitri , Mahdiyah Dede , TM M. Fajriannor 
Published: May 2024

Latar Belakang: Pusat Informasi Konseling Remaja (PIK-R) adalah suatu wadah yang dikembangkan dalam program GenRe, yang dikelola dari, oleh dan untuk remaja guna memebrikan pelayanan informasi dan konseling kepada remaja salah satunya upaya pendewasaan usia perwakinan untuk meminimalkan kejadian dari pernikahan usia dini. Kejadian pernikahan usia 15-19 tahun pada tahun 2018 Barito Kuala menduduki peringkat tertinggi sedangkan pada tahun 2022 barito Kuala menduduki peringkat ke 12.Tujuan: Mengetahui peranan Pusat Informasi Konseling remaja (PIK R) dalam meminimalkan kejadian pernikahan usia dini di Barito Kuala.Metode: Penelitian ini menggunakan metode deskriptif kualitatif, informan dalam penelitian sebanyak lima orang informan utama dan empat orang informan triangulasi. Pengumpulan data menggunakan wawancara mendalam dengan analisis isi.Hasil: Pernikahan usia dini yang terjadi di Barito Kuala masih sering terjadi dengan beberapa faktor yang mempengaruhinya yaitu pengetahuan, pergaulan, orang tua dan kebiasaan turun-temurun. Peran dari PIK R sendiri sudah cukup baik, namun SDM untuk PIK masih kurang, sehingga pelayanan yang diberikan masih sangat terbatas.Simpulan: Pusat Informasi Konseling Remaja di Barito Kuala berperan dalam meminimalkan kejadian pernikahan di usia dini.Saran: Diharapkan untuk meningkatkan promosi PIK R di kalangan remaja, agar peranan dari PIK R sendiri bisa terjalankan dengan baik Kata Kunci: pernikahan usia dini, Pusat Informasi Konseling Remaja (PIK R), remaja ABSTRACT Background: The youth counseling information center (PIK R) is a vessel developed in genre, run of, by, and for youth to provide information services and counseling to youth, one of which is an effort to increase the age of the delegation to minimize incidents of premature marriage. The incidence of a 15-19 - year - old wedding in 2018 named Barito Kuala finished its high rating by 2022; Barito Kuala received its 12th.Objective: Knowing the role of the youth counseling information center (PIK R) in minimizing youth wedding events in Barito Kuala.Methods: Qualitative descriptive methods, Informant in research as many as five key informant and four persons informant triangulation. Data collection USES in-depth interviews with content analysis.Results: Early marriage that takes place in barito Kuala Lumpur is not uncommon with some factors affecting his knowledge, associations, parents, and past customs. Whereas the role of the PIK R itself was good enough, however, because human resources for PIK R were so small that service was still so limited.Conclusion: The role of the youth counseling information center in Barito Kuala plays in minimizing premature marriage events.Suggestion: It is hoped to enhance the PIK R promotion among teenagers, so that the role of PIK R properly carried out. Keywords: youth, Youth Counseling Information Center (PIK R), Youth marriage,
Aplikasi Pemantauan Distribusi Air Minum dalam Kemasan (AMDK) Berbasis Website (Studi Kasus: CV. Sentosa Abadi)
Authors: Jaya Tri Kusuma , Ripanti Eva Faja , Asrin Fauzan 
Published: May 2024

Aplikasi pemantauan distribusi air minum dalam kemasan merupakan kegiatan yang melakukan proses pengelolaan data distribusi yang memiliki fungsi atau peran dalam menyelesaikan permasalahan seputar pencatatan, perhitungan, pembuatan laporan pendistribusian air minum dalam kemasan. Saat ini pendistribusian air minum dalam kemasan pada CV. Sentosa Abadi Sekadau kerap ditemukan adanya permasalahan, seperti belum adanya teknologi informasi pendukung untuk melakukan proses pencatatan, perhitungan serta penyimpanan data-data terkait pendistribusian, proses mengelola order, pencatatan produksi, pencatatan produk yang masih dikerjakan secara konvensional sehingga kerap terjadinya salah perhitungan maupun kehilangan data. Hal ini berdampak dalam pengelolaan pendistribusian air minum dalam kemasan menjadi tidak efektif dan efisien. Oleh karena itu, diperlukan sebuah teknologi informasi yang mampu untuk mewujudkan proses pemantauan distribusi menjadi lebih akurat dan optimal. Sistem yang dirancang ini menggunakan metode SDLC dengan pendekatan model Prototype dengan perancangan sistem menggunakan pemodelan Unified Modelling Language (UML). Hasil pengujian Black Box Testing dan User Acceptance Test (UAT) yang dilakukan menunjukan hasil positif bahwa proses yang ditampilkan telah sesuai harapan dan aplikasi berjalan dengan baik pada saat diuji dengan pengujian Black Box Testing dan diperoleh nilai dari pengujian User Acceptance Test (UAT) dari hasil kuesioner menggunakan Google Form dengan perhitungan Skala Likert kepada pengguna dengan keseluruhan nilai persentase 92% dengan hasil pengujian tersebut dapat dikatakan sangat setuju. Total responden yang mengisi kuesioner pengujian User Acceptance Test (UAT) berjumlah 11 responden. Berdasarkan dari hasil pengujian yang telah dilakukan pada pengguna bahwa aplikasi yang dibangun layak untuk diterapkan.
Salivary biomarkers as pioneering indicators for diagnosis and severity stratification of pediatric long COVID
Authors: Tyrkalska Sylwia D. , Pérez-Sanz Fernando , Franco-Martínez Lorena , Rubio Camila P. , Tvarijonaviciute Asta , Martínez-Subiela Silvia , Méndez-Hernández María , González-Aumatell Alba , Carreras-Abad Clara , Domènech-Marçal Èlia , Cerón José J. , Cayuela María L. , Mulero Victoriano , Candel Sergio 
Published: May 2024

IntroductionLong COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC), manifests as persistent and often debilitating symptoms enduring well beyond the initial COVID-19 infection. This disease is especially worrying in children since it can seriously alter their development. Presently, a specific diagnostic test or definitive biomarker set for confirming long COVID is lacking, relying instead on the protracted presence of symptoms post-acute infection.MethodsWe measured the levels of 13 biomarkers in 105 saliva samples (49 from children with long COVID and 56 controls), and the Pearson correlation coefficient was used to analyse the correlations between the levels of the different salivary biomarkers. Multivariate logistic regression analyses were performed to determine which of the 13 analysed salivary biomarkers were useful to discriminate between children with long COVID and controls, as well as between children with mild and severe long COVID symptoms.ResultsPediatric long COVID exhibited increased oxidant biomarkers and decreased antioxidant, immune response, and stress-related biomarkers. Correlation analyses unveiled distinct patterns between biomarkers in long COVID and controls. Notably, a multivariate logistic regression pinpointed TOS, ADA2, total proteins, and AOPP as pivotal variables, culminating in a remarkably accurate predictive model distinguishing long COVID from controls. Furthermore, total proteins and ADA1 were instrumental in discerning between mild and severe long COVID symptoms.DiscussionThis research sheds light on the potential clinical utility of salivary biomarkers in diagnosing and categorizing the severity of pediatric long COVID. It also lays the groundwork for future investigations aimed at unravelling the prognostic value of these biomarkers in predicting the trajectory of long COVID in affected individuals.
Harnessing the power of artificial intelligence in predicting all-cause mortality in transcatheter aortic valve replacement: a systematic review and meta-analysis
Authors: Sazzad Faizus , Ler Ashlynn Ai Li , Furqan Mohammad Shaheryar , Tan Linus Kai Zhe , Leo Hwa Liang , Kuntjoro Ivandito , Tay Edgar , Kofidis Theo 
Published: May 2024

ObjectivesIn recent years, the use of artificial intelligence (AI) models to generate individualised risk assessments and predict patient outcomes post-Transcatheter Aortic Valve Implantation (TAVI) has been a topic of increasing relevance in literature. This study aims to evaluate the predictive accuracy of AI algorithms in forecasting post-TAVI mortality as compared to traditional risk scores.MethodsFollowing the Preferred Reporting Items for Systematic Reviews and Meta-analyses for Systematic Reviews (PRISMA) standard, a systematic review was carried out. We searched four databases in total—PubMed, Medline, Embase, and Cochrane—from 19 June 2023–24 June, 2023.ResultsFrom 2,239 identified records, 1,504 duplicates were removed, 735 manuscripts were screened, and 10 studies were included in our review. Our pooled analysis of 5 studies and 9,398 patients revealed a significantly higher mean area under curve (AUC) associated with AI mortality predictions than traditional score predictions (MD: −0.16, CI: −0.22 to −0.10, p &lt; 0.00001). Subgroup analyses of 30-day mortality (MD: −0.08, CI: −0.13 to −0.03, p = 0.001) and 1-year mortality (MD: −0.18, CI: −0.27 to −0.10, p &lt; 0.0001) also showed significantly higher mean AUC with AI predictions than traditional score predictions. Pooled mean AUC of all 10 studies and 22,933 patients was 0.79 [0.73, 0.85].ConclusionAI models have a higher predictive accuracy as compared to traditional risk scores in predicting post-TAVI mortality. Overall, this review demonstrates the potential of AI in achieving personalised risk assessment in TAVI patients.Registration and protocolThis systematic review and meta-analysis was registered under the International Prospective Register of Systematic Reviews (PROSPERO), under the registration name “All-Cause Mortality in Transcatheter Aortic Valve Replacement Assessed by Artificial Intelligence” and registration number CRD42023437705. A review protocol was not prepared. There were no amendments to the information provided at registration.Systematic Review Registrationhttps://www.crd.york.ac.uk/, PROSPERO (CRD42023437705).
Effects of renin-angiotensin system inhibitor and beta-blocker use on mortality in older patients with heart failure with reduced ejection fraction in Japan
Authors: Kawada Kei , Ishida Tomoaki , Fukuda Hitoshi , Hyohdoh Yuki , Kubo Toru , Hamada Tomoyuki , Baba Yuichi , Hayashi Toshinobu , Aizawa Fuka , Yagi Kenta , Izawa-Ishizawa Yuki , Niimura Takahiro , Abe Shinji , Goda Mitsuhiro , Kitaoka Hiroaki , Ishizawa Keisuke 
Published: May 2024

IntroductionGuideline-directed medical therapy with renin-angiotensin system (RAS) inhibitors and beta-blockers has improved the survival of patients with heart failure (HF) and reduced left ventricular ejection fraction (HFrEF). However, it is unclear whether RAS inhibitors and beta-blockers can be administered to older patients with HF. Therefore, this study aimed to investigate the effects of beta-blockers and RAS inhibitors on the prognosis of older patients with HFrEF.MethodsDemographic, clinical, and pharmacological data from 1,061 patients with acute decompensated HF, enrolled in the Kochi Registry of Subjects with Acute Decompensated Heart Failure (Kochi YOSACOI study), were analyzed to assess their impact on mortality. Additionally, a machine learning approach was applied to complement the conventional statistical model for analysis. Patients with HFrEF (n = 314) were divided into the all-cause mortality within 2 years group (n = 80) and the survivor group (n = 234).ResultsOverall, 41.1% (129/314) of the patients were aged ≥80, and 25.5% (80/314) experienced all-cause mortality within 2 years. Furthermore, 57.6% (181/314) and 79.0% (248/314) were prescribed RAS inhibitors and beta-blockers, respectively. Our analysis showed that RAS inhibitor use was associated with reduced all-cause mortality and cardiac death in patients with HFrEF of all ages (P &lt; 0.001), and beta-blocker use had an interaction with age. Machine learning revealed that the use of beta-blockers altered the risk of mortality, with a threshold of approximately 80 years of age. Beta-blocker use was associated with lower all-cause mortality and cardiac death in patients with HFrEF aged &lt;80 years (P &lt; 0.001) but not in those aged ≥80 years (P = 0.319 and P = 0.246, respectively). These results suggest that beta blockers may differ in their all-cause mortality benefits according to age.ConclusionsRAS inhibitors prevented all-cause mortality and cardiac death at all ages, whereas beta-blockers had different effects depending on the patient's age. This study suggested that the choice of beta-blockers and RAS inhibitors is more important in older patients with HFrEF than in younger patients with the same condition.
Smoothelin-like protein 1 promotes insulin sensitivity and modulates the contractile properties of endometrial epithelial cells with insulin resistance
Authors: Keller Ilka , Ungvári Ádám , Kinter Richárd , Szalmás Fanni , Kókai Endre , Lontay Beáta 
Published: May 2024

IntroductionThe incidence of infertility is significantly higher in women with diseases linked to impaired glucose homeostasis, such as insulin resistance. Defective glucose metabolism interferes with fertilization; however, the molecular mechanism underlying this interference is unclear. Smoothelin-like protein 1 (SMTNL1) was isolated from muscle and steroid hormone-responsive tissues and regulates the contractile functions of various cell types through the inhibition of myosin phosphatase (MP) holoenzyme. In addition, SMTNL-1 after phosphorylation at Ser301 by protein kinase A translocates to the nucleus and functions as a transcriptional co-activator of the progesterone receptor-B. SMTNL1 null mice exhibit reduced reproductive fitness and are more prone to type 2 diabetes mellitus. However, the role of SMTNL1 in endometrial epithelial cells is not known.MethodsThe effect of SMTNL1 overexpression was investigated in pregnancy and in gestational diabetic endometrial epithelial cell models by immunofluorescent staining, cell migration, and semi quantitative Western blot analysis and glucose uptake assay.ResultsWe show that SMTNL1 promotes the differentiation of endometrial epithelial cells in a progesterone-dependent manner to attenuate insulin resistance. Furthermore, SMTNL1 hampers the migration capacity of epithelial cells in a gestational diabetes model by inhibiting the expression of MYPT1, the regulatory subunit of MP, and the activity of the holoenzyme, resulting in increased phosphorylation of the 20 kDa regulatory myosin light chain. SMTNL1 also acts as an insulin-sensitizing agent by increasing the gene expression of PP2A and DUPS9 protein phosphatases, resulting in decreased ERK1/2 activity and, hence, decreasing the phosphorylation of IRS-1 at Ser612 under gestational diabetes conditions.ConclusionSMTNL1 may have therapeutic relevance to the progesterone-dependent inhibition of endometrial epithelial cell migration under hyperglycemic conditions and insulin sensitivity in the endometrium in gestational diabetes or other metabolic disorders.
C1q is elevated during chronic Staphylococcus epidermidis central nervous system catheter infection
Authors: Beaver Matthew , Bergdolt Lara , Dunaevsky Anna , Kielian Tammy , Skar Gwenn L. 
Published: May 2024

IntroductionSignificant neurologic morbidity is caused by pediatric cerebrospinal fluid (CSF) shunt infections. The underlying mechanisms leading to impaired school performance and increased risk of seizures are unknown, however, a better understanding of these mechanisms may allow us to temper their consequences. Recent evidence has demonstrated important roles for complement proteins in neurodevelopment and neuroinflammation.MethodsWe examined complement activation throughout Staphylococcus epidermidis (S. epidermidis) central nervous system (CNS) catheter infection. In addition, based on accumulating evidence that C3 plays a role in synaptic pruning in other neuroinflammatory states we determined if C3 and downstream C5 led to alterations in synaptic protein levels. Using our murine model of S. epidermidis catheter infection we quantified levels of the complement components C1q, Factor B, MASP2, C3, and C5 over the course of infection along with bacterial burdens.ResultsWe found that MASP2 predominated early in catheter infection, but that Factor B was elevated at intermediate time points. Unexpectedly C1q was elevated at late timepoints when bacterial burdens were low or undetectable. Based on these findings and the wealth of information regarding the emerging roles of C1q in the CNS, this suggests functions beyond pathogen elimination during S. epidermidis CNS catheter infection. To identify if C3 impacted synaptic protein levels we performed synaptosome isolation and quantified levels of VGLUT1 and PSD95 as well as pre-, post- and total synaptic puncta in cortical layer V of C3 knockout (KO) and wild type mice. We also used C5 KO and wild type mice to determine if there was any difference in pre-, post- and total synaptic puncta.DiscussionNeither C3 nor C5 impacted synaptic protein abundance. These findings suggest that chronic elevations in C1q in the brain that persist once CNS catheter infection has resolved may be modulating disease sequalae.
TLR2/4 are novel activating receptors for SARS-CoV-2 spike protein on NK cells
Authors: Landolina Nadine , Ricci Biancamaria , Veneziani Irene , Alicata Claudia , Mariotti Francesca Romana , Pelosi Andrea , Quatrini Linda , Mortari Eva Piano , Carsetti Rita , Vacca Paola , Tumino Nicola , Azzarone Bruno , Moretta Lorenzo , Maggi Enrico 
Published: May 2024

BackgroundIn early infected or severe coronavirus disease 2019 (COVID-19) patients, circulating NK cells are consistently reduced, despite being highly activated or exhausted. The aim of this paper was to establish whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein (SP) may directly trigger NK cells and through which receptor(s).MethodsSP-stimulated human NK cells have been evaluated for the expression of activation markers, cytokine release, and cytotoxic activity, as well as for gene expression profiles and NF-kB phosphorylation, and they have been silenced with specific small interfering RNAs.ResultsSPs from the Wuhan strain and other variants of concern (VOCs) directly bind and stimulate purified NK cells by increasing activation marker expression, cytokine release, and cytolytic activity, prevalently in the CD56brightNK cell subset. VOC-SPs differ in their ability to activate NK cells, G614, and Delta-Plus strains providing the strongest activity in the majority of donors. While VOC-SPs do not trigger ACE2, which is not expressed on NK cells, or other activating receptors, they directly and variably bind to both Toll-like receptor 2 (TLR2) and TLR4. Moreover, SP-driven NK cell functions are inhibited upon masking such receptors or silencing the relative genes. Lastly, VOC-SPs upregulate CD56dimNK cell functions in COVID-19 recovered, but not in non-infected, individuals.ConclusionsTLR2 and TLR4 are novel activating receptors for SP in NK cells, suggesting a new role of these cells in orchestrating the pathophysiology of SARS-CoV-2 infection. The pathogenic relevance of this finding is highlighted by the fact that free SP providing NK cell activation is frequently detected in a SARS-CoV-2 inflamed environment and in plasma of infected and long-COVID‐19 subjects.