bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurosurgical Management of Patients with Alpha-Gal Syndrome
Authors: Carlstrom Lucas P. , Akhter Asad , Macielak Robert J. , Callejas Claudio A. , Eickstaedt Jennifer E. , Brooks Christopher , Koevering Kyle Van , Schoo Desi , Wu Kyle C. , Prevedello Daniel M. 
Published: June 2024

AbstractAlpha-gal syndrome (AGS) is an immunoglobulin E–mediated hypersensitivity to galatcose-alpha-1,3-galactose (alpha-gal), a carbohydrate compound present in nonprimate mammalian products. Initial exposure to alpha-gal most often occurs through a tick bite, most commonly the lone star tick in the United States. Repeated exposure to alpha-gal may elicit severe allergic reactions, including anaphylaxis. The allergy restricts dietary intake and may significantly impact perioperative risk, as many medications, anesthetics, and intraoperative surgical products utilize bovine or porcine-derived agents, including those containing magnesium stearate, glycerol, and gelatin. Here, we review the perineurosurgical care of two individuals with AGS and highlight pertinent clinical practices and perioperative management of these patients.
A Patient with Multiple System Atrophy-Parkinsonian Type Presenting with Progressive Micrographia
Authors: Onder Halil , Cetin Beyza Nur , Comoglu Selcuk 
Published: June 2024

AbstractHerein, we present the case of a 57-year-old male patient who was admitted to our center due to progressive writing difficulty and slowness of his right hand over the last 3 years. In conclusion of the clinical and laboratory workup, a diagnosis of multiple system atrophy (MSA) was established. Our report on progressive micrographia (PM) constitutes a crucial sample remarking on this intriguing manifestation in another disease subtype of MSA, which differs from Parkinson's disease in terms of the clinical and pathophysiological processes. We think that further studies are warranted to clarify the significance of this entity in movement disorder in clinical practice and to reveal the underlying neural mechanisms.
Hair Transplantation on the Baldness Region with Free Latissimus Dorsi Flap for Scalp Reconstruction: A Case Report
Authors: Han Man Wong , Moh Jaeseong , Park Ji-Ung 
Published: June 2024

AbstractScalp reconstruction, particularly with complex defects and infection risks, often favors microvascular free flaps. However, this method can result in unavoidable alopecia and undesirable aesthetics. This report describes a novel case where hair transplantation via follicular unit extraction (FUE) was applied to a free myocutaneous flap. A 44-year-old woman with Moyamoya disease suffered intracerebral hemorrhage a decade ago. Craniotomies and autologous bone cranioplasties led to wound dehiscence, with subsequent failed local flaps and skin grafts, and identification of a methicillin-resistant Staphylococcus aureus infection. The final scalp defect, measuring 13 × 9 cm, was reconstructed using a free myocutaneous latissimus dorsi flap. Nine years post-surgery, a 1,500-unit FUE hair transplantation procedure was conducted. The transplanted hair exhibited robust survival with adequate blood supply, achieving a satisfactory 80 to 85% survival rate at 12 months. This resulted in a notable improvement in the patient's external alopecia, with reported high levels of satisfaction. Free flaps offer a valuable method for scalp defect reconstruction; however, they may not ensure optimal aesthetic satisfaction due to alopecia. Nonetheless, successful FUE hair transplantation on a myocutaneous free flap can yield satisfactory aesthetic results.
Induction versus Adjuvant Chemotherapy Combined with Concurrent Chemoradiation: What Is Beneficial in Locally Advanced Nasopharyngeal Carcinoma—A 5-Year Comparative Study at a Tertiary Care Center in North India
Authors: Fatima Kaneez , Andleeb Asifa , Nasreen Shahida , Sofi Mushtaq Ahmad , Wani Ulfat Ara , Rasool Malik Tariq , Najmi Arshad Manzoor , Qamar Shaqul , Ahmad Nazir , Ryhan Rubiya 
Published: June 2024

Background In locally advanced nasopharyngeal cancer (LANPC), concurrent chemoradiotherapy (CCRT) has been established as the current standard of care, but recently, the addition of induction chemotherapy to CCRT has presented an attractive multidisciplinary approach.
Objectives The aim of the study was to explore the clinical outcome of induction chemotherapy (IC) followed by CCRT and CCRT followed by adjuvant chemotherapy (AC) in LANPC.
Material and Methods In this propensity score–matched retrospective cohort study, we enrolled LANPC patients from October 2016 to June 2022. Study variables were evenly distributed by propensity score matching. Independent prognostic factors were identified using Cox regression analysis, and the outcome between the two chemotherapy treatment combinations was compared for patients in different subgroups.
Result A total of 80 patients were included in the study. Survival outcomes indicated that the IC followed by CCRT group (IC + CCRT) achieved a higher 5-year overall survival (OS; 90 vs. 81%, p = 0.253), failure-free survival (FFS; 80 vs. 77.50%, p = 0.17), and distant metastasis-free survival (DMFS; 88 vs. 82.50%, p = 0.314) compared with the CCRT followed by AC group (CCRT + AC), although it was not statistically significant. The stratified analysis revealed that IC followed by CCRT (IC + CCRT) was associated with significantly improved OS (hazard ratio [HR] = 0.212; 95% confidence interval [CI] = 0.014–3.16; p = 0.0026) in N2 disease. However, the superiority of CCRT followed by AC (CCRT + AC) was only observed in LRRFS (HR = 0.45; 95% CI = 0.05–0.89; p = 0.036) for the T4 subgroup.
Conclusion In patients with LANPC, especially with T3 or N2 disease, IC should be strongly considered followed by CCRT.
Analyzing market basket data through sparse multivariate logit models
Authors: Hruschka Harald 
Published: June 2024

AbstractUsing multivariate logit models, we analyze purchases of product categories made by individual households. We introduce a sparse multivariate logit model that considers only a subset of all two-way interactions. A combined forward and backward selection procedure based on a cross-validated performance measure excludes about 74 % of the possible two-way interactions. We also specify random coefficient versions of both the non-sparse and the sparse model. The fact that the random coefficient models lead to better values of the Bayesian information criterion demonstrates the importance of latent heterogeneity. The random coefficients sparse model attains the best statistical performance if we consider model complexity and offers a better interpretability. We investigate the cross-purchase effects of household segments derived from this random coefficient model. As additional interpretation aid we cluster categories and category pairs by integer programming. We demonstrate what the best performing sparse model implies for cross-selling by product recommendations and store layout. The sparse model leads to managerial implications with respect to the effects of advertising in local newspapers and flyers that are as a rule close to those implied by its non-sparse counterpart.
Revolving door benefits? The consequences of the revolving door for political access
Authors: Egerod Benjamin C. K. , Rasmussen Anne , van der Ploeg Jens 
Published: June 2024

AbstractDo policymakers grant greater access to organized interests employing their former colleagues? While a growing literature examines the “revolving door” between business and politics, we know little about whether organized interests can extract political favors by hiring revolvers. Combining novel data on the career trajectories of European Union officials and politicians with access data to the European Commission, we use a difference-in-differences strategy to estimate how hiring revolvers shapes access to meetings with policymakers. Surprisingly, we find limited evidence that employing politically connected staff shapes access overall. However, we uncover substantial heterogeneities in the effects, suggesting that revolvers do increase access to meetings about the broader legislative agenda when institutional friction is low. Moreover, contract lobbying firms, which arguably possess the weakest level of legitimacy, experience increased access. Our article sheds new light on the circumstances under which revolvers with political connections help private interests and have important implications for understanding the political effects of the revolving door.
Camel milk composition and future market potential
Authors: Faye Bernard , Konuspayeva Gaukhar 
Published: June 2024

Abstract
Many “reviews of reviews” were published almost every month to vent the health claims of camel milk, attributing to it, many “therapeutic virtues” without critical look. However, camel milk cannot be considered as a medicine because it is first and foremost a food even if some health effects and undeniable dietetic properties can be attributed to some of its components. However, these health claims are undeniable commercial arguments contributing to the current development of the sector on a global scale (around 5.5% annual growth), despite the many constraints linked to the desert environment in which most of the camel farms are living. This publication therefore briefly reviews the main components of milk with a potential health effect and/or dietary interest and which constitute a springboard for a rapid development of the camel milk economy worldwide.
Res-BiLSTMs model based on multi-task attention for real-time measurement of the free calcium oxide content
Authors: Zhao Yantao , Wang Yao , Zhang Shanshan , Wang Xin , Yu Hongnian 
Published: June 2024

Abstract
The content of free calcium oxide (f-CaO) is the primary economic index to evaluate the quality of cement. A residual bidirectional long short-term memory network model (Res-BiLSTMs) based on a multi-task attention mechanism was proposed for the characteristics of cement clinker production, used for online monitoring f-CaO content. The model utilizes the Bi-LSTM as the foundational component and combines the residual network to construct the Res-BiLSTMs coding structure, which aims to summarize the multi-level characteristic information of the input sequence. Additionally, a multi-task attention mechanism is introduced, combining the attention mechanism with semi-supervision to extract control coupling and data coupling among devices and variables. The results demonstrate that the addition of the multi-task attention mechanism led to a reduction in model errors by 0.0175 and 0.022, respectively, and an improvement in the degree of fit by 14.61%. The effectiveness of the multi-task attention mechanism for quality monitoring is confirmed. Compared to traditional LSTM, this model exhibited a reduction in errors by 0.0469 and 0.019, respectively, an increase in the correlation coefficient by 45.37%, and outperformed all other models in the comparison. The model’s measurement performance under limited labeled samples is also validated.
Glutathione and acid dual-responsive bismuth-based nanosensitizer for chemo-mediated cancer sonodynamic therapy
Authors: Chen Guobo , Ping Jing , Du Jun , Zhao Linghao , Li Yuhao , Liu Hui 
Published: June 2024

Abstract
Chemotherapeutic agents hold significant clinical potential in combating tumors. However, delivering these drugs to the tumor site for controlled release remains a crucial challenge. In this study, we synthesize and construct a glutathione (GSH) and acid dual-responsive bismuth-based nano-delivery platform (BOD), aiming for sonodynamic enhancement of docetaxel (DTX)-mediated tumor therapy. The bismuth nanomaterial can generate multiple reactive oxygen species under ultrasound stimulation. Furthermore, the loading of DTX to form BOD effectively reduces the toxicity of DTX in the bloodstream, ensuring its cytotoxic effect is predominantly exerted at the tumor site. DTX can be well released in high expression of GSH and acidic tumor microenvironment. Meanwhile, ultrasound can also promote the release of DTX. Results from both in vitro and in vivo experiments substantiate that the synergistic therapy involving chemotherapy and sonodynamic therapy significantly inhibits the growth and proliferation of tumor cells. This study provides a favorable paradigm for developing a synergistic tumor treatment platform for tumor microenvironment response and ultrasound-promoted drug release.
Greenhouse gas emissions from hydropower reservoirs: emission processes and management approaches
Authors: Wang Zilin , Chan Faith Ka Shun , Feng Meili , Johnson Matthew F 
Published: June 2024

Abstract
Hydropower reservoirs, as vital inland waters bodies of anthropogenic origin, exhibit distinct characteristics from natural waters, thereby garnering research interest in the quantification and mapping of greenhouse gas (GHG) emissions. In this review, we systematically examine studies focusing on GHG emissions from hydropower reservoirs. We identify two key primary physical mechanisms resulting from river damming, namely water impoundment and water regulation, which can significantly influence GHG emissions in hydropower reservoirs. Reservoirs vary in size, with smaller reservoirs exhibiting higher CH4 emissions per unit area. For instance, small reservoirs have an average flux rate of 327.54 mg C–CH4/m2/day, while medium-sized reservoirs emit 267.12 mg C–CH4/m2/day, and large ones emit 37.34 mg C–CH4/m2/day. This difference is potentially attributable to shorter water residence times in small reservoirs and increased susceptibility to littoral disturbance. In addition to reservoir scale, variations in GHG emissions between reservoirs are also influenced by the type of hydropower. Run-of-river and closed-loop pumped storage hydropower (PSH) systems are anticipated to exhibit lower GHG emissions (PSH: 4.2–46.5 mg C–CH4/m2/day) in comparison to conventional impoundment hydropower, owing to their operational characteristics, facilitating mixing and oxygenation within the reservoir water column and reducing sedimentation. Nonetheless, further field measurements are warranted. Through the integration of literature insights, we propose solutions aimed at managing emissions, considering both physical mechanisms and hydropower planning. Ultimately, these findings will advance our understanding of GHG emissions from hydropower reservoirs and facilitate sustainable carbon reduction management practices.
Voluntary uptake of flood insurance in post-fire landscapes: insights from household surveys after two wildfires in northern Arizona
Authors: Edgeley Catrin M , Colavito Melanie M , vonHedemann Nicolena , Burnett Jack T 
Published: June 2024

Abstract
Wildfires can rapidly generate post-fire flood risk for downslope communities, complicating recovery and necessitating accelerated cross-boundary responses on both public and private lands. Flood insurance is one of a suite of efforts to minimize the social and financial impacts associated with post-fire flood events, but little is known about who purchases coverage after wildfires or their experiences with insurance claims. We provide an opportunistic contribution to this research gap by comparing data gathered via three mixed-mode household surveys conducted in areas with modeled flood risk after two wildfires in the greater Flagstaff, Arizona area. Two surveys were administered—one in 2011 and one in 2020—after the 2010 Schultz Fire, which resulted in significant flooding, providing a longitudinal insight into insurance experiences. A third survey was administered in 2022 following flooding adjacent to the 2019 Museum Fire. Together, these surveys resulted in a total of 1,351 usable responses. We find that several groups are significantly less likely to purchase flood insurance, including residents who moved to their property after the studied fire event and renters. The reported cost of flood insurance among households affected by the Schultz Fire doubled over a 10-year period; those who no longer maintained coverage typically reported that they stopped renewing between 2–5 years after the fire. Second homeowners were more likely to report damages that were not covered by insurance. We provide recommendations for engaging residents in uptake, renewal, and use of flood insurance and conclude that there is an urgent need to better understand decision-making surrounding post-fire flood insurance to support more equitable recovery.
First measurements of the airglow emissions from Kolhapur using an in-house developed Fabry–Perot interferometer
Authors: Mahavarkar Prasanna , Sriram S , Joshi Bhagyashree , Gurubaran S 
Published: June 2024

Abstract
First-time airglow observations of the nighttime thermospheric wind from an in-house developed ground-based Fabry–Perot Interferometer are recorded from the Kolhapur location of India. This was the first attempt to build such an instrument, and thus the quality of the data recorded in the field is satisfactory. The instrument has been thoroughly calibrated in the laboratory, and the accuracy of the important parameter finesse of the etalon is found to be ≈94% in agreement with the value supplied by the manufacturer. The airglow observations from the field indicate that the vertical wind observed looking toward Zenith over the course of the night is zero, ensuring a 100% accuracy. However, the temperature measurements were found to be approximately 30% in agreement with the measurements repoted in literature. To improve this measurement, improvements in the optical design need to be made. The paper concludes with conclusions and a brief idea of the proposed improvisations in the design.
The EU Web of Competences and Food Law
Authors: Schebesta Hanna , Purnhagen Kai 
Published: June 2024

Abstract
The EU can legislate in the food domain only within the confines of competences conferred to it by the Member States in EU Treaties. This chapter provides an overview of the various competence areas that are relevant in EU Food Law (section 2.2). These are, namely, agriculture (section 2.2.1), the internal market (section 2.2.2), consumer law (section 2.2.3), the environment (section 2.2.4), health (section 2.2.5), and solidarity (section 2.2.6). The implications of fundamental rights are also discussed (section 2.3). The chapter shows that EU food law is based on a ‘web of competences’ rather than a specific isolated competence norm.
Pre-Market Authorizations of Novel Products
Authors: Schebesta Hanna , Purnhagen Kai 
Published: June 2024

Abstract
This chapter discusses the pre-market authorization of novel food according to the Novel Food Regulation (NFR) (section 7.2). It outlines its legal basis, objectives (section 7.3), and scope (section 7.4), after which a closer look is taken at more specific regulatory aspects, such as the consultation process to determine the novel food status (section 7.5), the Union list of novel food (section 7.6), and the general authorization process to be listed on it (section 7.6.2). The alternative process of notifying or applying for authorization of a traditional food from a third country is also explained (section 7.6.3). In addition, the chapter outlines the inherent risk assessment process by the European Food Safety Authority (EFSA) (section 7.7) and the effects of authorization with regard to data ownership (section 7.8). The final section reflects on the advantages and disadvantages of the NFR (section 7.9).
Philosophy, the Good Life, and Spirituality
Authors: Cottingham John 
Published: June 2024

AbstractThis chapter, drawing on the work of the philosopher Pierre Hadot, distinguishes between philosophy as a specialized academic discipline, concerned with careful examination of our concepts, and philosophy as a way of life, concerned with an examination of the overall meaning and purpose of our lives and with the ‘care of the soul’. The latter conception is connected with the kinds of human need that tend to be labelled ‘spiritual’, and the chapter proceeds to examine various purely secular treatments of spiritual praxis and spiritual experience, contrasting these with the kinds of account found in religious writers. It is concluded that when we unpack exactly what is involved in the activities and experiences we call spiritual, it is not easy to make adequate sense of spirituality, and of its importance for human life, without something close to a theistic framework.
Which Naturalism?
Authors: Cottingham John 
Published: June 2024

AbstractThis chapter examines the ‘naturalizing’ agenda of contemporary secularist philosophy. The history of the terms ‘nature’ and ‘natural’ reveals a discontinuity between present-day and earlier understandings of these terms. Given the radical shift in how the natural domain is understood, today’s ‘naturalist’ philosophers, insisting that all phenomena fall within the domain of the natural, are advancing a thesis that many classical, medieval, and early-modern philosophers and theologians would have regarded as self-evident. The philosophically interesting question is not whether we should be naturalists, but which of two naturalisms we should adopt: secular naturalism, with its neutral or blank conception of nature in general and human nature in particular, or theistic naturalism, according to which both the natural world and our own nature bear the stamp of the divine. The chapter concludes by suggesting that the former (secularist) view faces serious difficulties, on both the epistemic and the moral fronts.
Exploring the link between occupationally relevant whole body vibration and headache and neck pain: is elevated muscle tension an intermediary factor?
Authors: Yung Marcus , Milosavljevic Stephan , Lang Angelica E , Tennant Liana M , Trask Catherine 
Published: June 2024

Abstract
Whole body vibration (WBV) is linked to short- and longer-term adverse health outcomes, including cognitive impairment, stress and memory loss, loss of balance, reduced proprioception, visual and vestibular disturbances, gastrointestinal problems, and musculoskeletal disorders. Epidemiological evidence supports the link between WBV and headache and head discomfort, but few experimental studies have examined this relationship, particularly with increased muscle tension, as an intermediary. This study aimed to investigate the relationship between muscle tension and vibration intensity, between perceived neck pain and headache/head discomfort and vibration intensity, and between muscle tension and reported neck pain and headache symptoms from simulated WBV based on field measurements of all-terrain vehicle operation on farm terrain. We observed significantly higher electromyography amplitude in the High condition (equivalent to EU Directive’s Exposure Limit Value) compared to both Low (equivalent to EU Directive’s Exposure Action Value) and Control (quiet sitting) conditions at the left upper trapezius muscle but there were no significant time effects. Neck pain and headache/head discomfort significantly increased after both Low (91% increase from baseline) and High (154% increase from baseline) vibration conditions but there were no significant differences between conditions. Based on simple regression modeling, the relationship between muscle activity and neck pain or headache was very weak (R2 = 0–0.093). Given the possibility of multiple factors contributing to headache symptoms, future research should not only consider the role of muscle tension but also sensory conflict, excessive noise, biodynamic responses, and a combination of these factors.