bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypothermia‐induced increase of oligodendrocyte precursor cells: Possible involvement of plasmalemmal voltage‐dependent anion channel 1
Authors: Imada Shinya , Yamamoto Masahiro , Tanaka Kayoko , Seiwa Chika , Watanabe Kenji , Kamei Yoshimasa , Kozuma Shiro , Taketani Yuji , Asou Hiroaki 
Published: October 2010

AbstractHypothermia is believed to suppress cell proliferation by inducing apoptosis/necrosis and phase‐specific/nonspecific cell cycle arrest, which are, directly or indirectly, related to a reduced energy supply. Intriguingly, hypothermia is known to improve neurological recovery of animals and humans exposed to focal brain hypoxic‐ischemic injury. The underlying mechanism of the neuroprotective effect of hypothermia is unclear, although the prevention of neural cell apoptosis is thought to play a role. Herein we demonstrate that in vitro cell culture of oligodendrocyte precursor cells (OPCs) under conditions of mild hypothermia (31.5°C) results in an increase in cell number relative to cells cultured under normothermic conditions (37°C). Cell cycle analysis, immunoblotting of cyclins, TUNEL assay, and immunocytochemistry of OPC differentiation markers suggest that hypothermia shifts the balance between proliferation and apoptosis/differentiation toward proliferation. A combination of transcriptome analysis, pharmacological intervention, and immunoaffinity‐based assays suggests a possible involvement of the Gα13–Rho GTPase Cdc42–ERK1/2 signaling cascade and voltage‐dependent anion channel 1 (VDAC1), which associate or dissociate with Gα13 protein at 37°C and 31.5°C, respectively. Immunoelectron microscopy revealed the presence of VDAC1 in the plasma membrane of OPCs. Furthermore, the exogenous addition of impermeable VDAC1 inhibitors enhanced proliferation of OPCs at 37°C. These results may contribute to the elucidation of the mechanism of hypothermic neuroprotection as well as the possible novel role of plasmalemmal VDAC1. © 2010 Wiley‐Liss, Inc.
The wheat germ agglutinin‐fractionated proteome of subjects with Alzheimer's disease and mild cognitive impairment hippocampus and inferior parietal lobule: Implications for disease pathogenesis and progression
Authors: Di Domenico Fabio , Owen Joshua B. , Sultana Rukhsana , Sowell Rena A. , Perluigi Marzia , Cini Chiara , Cai Jian , Pierce William M. , Butterfield D. Allan 
Published: October 2010

AbstractLectin affinity chromatography is a powerful separation technique that fractionates proteins by selectively binding to specific carbohydrate moieties characteristic of protein glycosylation type. Wheat germ agglutinin (WGA) selectively binds terminal N‐acetylglucosamine (O‐GlcNAc) and sialic acid moieties characteristic of O‐linked glycosylation. The current study utilizes WGA affinity chromatography to fractionate proteins from hippocampus and inferior parietal lobule (IPL) from subjects with Alzheimer's disease (AD) and arguably its earliest form, mild cognitive impairment (MCI). Proteins identified by proteomics that were fractionated from MCI and AD hippocampus by WGA affinity chromatography with altered levels compared with age‐matched controls included GP96, γ‐enolase, glutamate dehydrogenase, glucosidase IIα, 14‐3‐3ϵ, 14‐3‐3γ, 14‐3‐3ζ, tropomyosin‐2, calmodulin 2, gelsolin, β‐synuclein, α1‐antichymotrypsin, and dimethylguanosine tRNA methyltransferase. Proteins identified by proteomics that were fractionated from MCI and AD IPL by WGA affinity chromatography showing altered levels compared with age‐matched controls included protein disulfide isomerase, calreticulin, and GP96. The proteins described in this study are involved in diverse processes, including glucose metabolism, endoplasmic reticulum (ER) functions, chaperoning, cytoskeletal assembly, and proteolysis, all of which are affected in AD. This study, the first to use proteomics to identify WGA‐fractionated proteins isolated from brains from subjects with MCI and AD, provides additional information about the active proteome of the brain throughout AD progression. © 2010 Wiley‐Liss, Inc.
Functionalization of Polysulfones by Click Chemistry
Authors: Toiserkani Hojjat , Yilmaz Gorkem , Yagci Yusuf , Torun Lokman 
Published: October 2010

AbstractFunctionalization of polysulfones by using “Click” chemistry is described for the example of a small fluorescent analyte propargylpyrene. First, PSUs were converted to azido‐functionalized polymers by successive chloromethylation and azidation. Propargylpyrene was prepared independently as a fluorescent click component. Finally, the azido‐functionalized PSUs were coupled with propargylpyrene with high efficiency by copper‐catalyzed azide/alkyne click reactions. The final polymers and intermediates at various stages were characterized by 1H NMR, FT‐IR, GPC, UV‐Vis, and fluorescence spectroscopy techniques. magnified image
Effect of Silicone Carbide on the Elastic Properties of Starch‐Based Composites: A Three‐Phase Model
Authors: Rjafiallah Said , Guessasma Sofiane 
Published: October 2010

AbstractThe effect of a rigid filler on the elastic properties of starch‐based composites is investigated. Thermomolding of the targeted composite is conducted using a starch matrix with varying silicone carbide content. Mechanical testing reveals that the composite's Young modulus cannot be rationalized using two‐phase analytical models. The effect of a weak interphase region is highlighted using a finite‐element model that assumes the generation of virtual microstructures. Numerical results are discussed by describing the influence of the structural and interphase parameters on the composite's elastic modulus. Identification of optimal interphase parameters quantitatively demonstrates the weak adhesion between intrinsic phases for all studied filler fractions. magnified image
The role of emotional wisdom in salespersons' relationships with colleagues and customers
Authors: Bagozzi Richard P. , Belschak Frank , Verbeke Willem 
Published: October 2010

AbstractEmotional wisdom is defined as a set of seven dimensions of basic skills and meta‐narratives concerning how to regulate emotions within specific domains in such a way that the individual's and firm's well‐being are tied together. Using operationalizations of emotional wisdom for salespersons from a wide range of industries (Study 1) and in automotive dealerships (Study 2), with respect to both colleagues and customers, it is discovered that salespeople who score high on emotional wisdom cope differently with socially challenging situations and achieve better social relationships than those who score low on emotional wisdom. © 2010 Wiley Periodicals, Inc.
“I won't leave you although you disappoint me”: The interplay between satisfaction, investment, and alternatives in determining consumer–brand relationship commitment
Authors: Sung Yongjun , Choi Sejung Marina 
Published: October 2010

AbstractWhile commitment is among the key constructs of consumer–brand relationships, past research has regarded the impact of predictors of brand commitment as being linear and has ignored potential interactive effects among the different antecedents. Applying the investment model of interpersonal relationship, the present research examines the dynamic interplay among the key determinants of consumers' commitment to their relationship with brands (satisfaction, alternatives, and investment) and substantiates the roles of the antecedents in consumer–brand relationship contexts. Results of two studies demonstrate that greater consumer satisfaction and investment and less attractive alternatives lead to a higher level of consumers' commitment to their relationship with a brand. Most important, the results suggest that the perceived size of investment exerts a stronger impact on brand relationship commitment when satisfaction is low while making no significant difference in the commitment level when satisfaction is high. Conversely, the influence of alternative attractiveness on brand relationship commitment appeared to be largely monotonic. © 2010 Wiley Periodicals, Inc.
Silica‐Protected Micron and Sub‐Micron Capsules and Particles for Self‐Healing at the Microscale
Authors: Jackson Aaron C. , Bartelt Jonathan A. , Marczewski Kamil , Sottos Nancy R. , Braun Paul V. 
Published: October 2010

AbstractA generalized silica coating scheme is used to functionalize and protect sub‐micron and micron size dicyclopentadiene monomer‐filled capsules and polymer‐protected Grubbs' catalyst particles. These capsules and particles are used for self‐healing of microscale damage in an epoxy‐based polymer. The silica layer both protects the capsules and particles, and limits their aggregation when added to an epoxy matrix, enabling the capsules and particles to be dispersed at high concentrations with little loss of reactivity. magnified image
A comparison of archaeological and dental evidence to determine diet at a predynastic Egyptian site
Authors: Gamza T. , Irish J. 
Published: October 2010

ABSTRACTThis paper explores the relationship between dietary evidence found in the archaeological record and that of the dentitions on a sample of working class Predynastic Egyptians from Hierakonpolis in Upper Egypt. The samples consist of 196 individuals (3800–3600BC) ranging from 6 years to over 50 years of age. Archaeological and archaeobotanical evidence at Hierakonpolis suggests manufacture of bread, presence of some domesticated animals, hunting and fishing, and a number of fruits and vegetables. Dental indicators of diet studied include carious lesions, macrowear, microwear and linear enamel hypoplasia. The patterns on the dentition match well with a number of food stuffs found as burial offerings and within settlements at Hierakonpolis. Overall, individuals at Hierakonpolis exhibited a low incidence of small carious lesions, a low frequency of acute hypoplastic defects, steady attrition, few microwear features, a low density of large (> 4 microns) pits, and wide scratches with poorly defined margins. Based on the dentition, the working class population would have relied heavily on bread and raw, but also consumed some meat and/or fish. Within sample variation shows that the proportion of certain food categories differ between adult males and females and between adults and juveniles. LEH data suggests that children suffered no long‐term starvation or chronic stress. Copyright © 2010 John Wiley & Sons, Ltd.
Immunohistochemical expression of conjugating UGT1A‐derived isoforms in normal and tumoral drug‐metabolizing tissues in humans
Authors: Bellemare Judith , Rouleau Mélanie , Harvey Mario , Popa Ion , Pelletier Georges , Têtu Bernard , Guillemette Chantal 
Published: October 2010

AbstractGlucuronidation by UDP‐glucuronyltransferase (UGT) enzymes is the prevailing conjugative pathway for the metabolism of both xenobiotics and endogenous compounds. Alterations in this pathway, such as those generated by common genetic polymorphisms, have been shown to significantly impact on the health of individuals, influencing cancer susceptibility, responsiveness to drugs and drug‐induced toxicity. Alternative usage of terminal exons leads to UGT1A‐derived splice variants, namely the classical and enzymatically active isoforms 1 (i1) and the novel enzymatically inactive isoforms 2 (i2).In vitrofunctional data from heterologous expression and RNA interference experiments indicate that these i2 isoforms act as negative modulators of glucuronidation, likely by forming inactive complexes with active isoform 1. We used specific antibodies against either active i1 or inactive i2 proteins to examine their distribution in major drug‐metabolizing tissues. Data revealed that UGT1A_i1 and inactive UGT1A_i2 are co‐produced in the same tissue structures, including liver, kidney, stomach, intestine and colon. Examination of the cellular distribution and semi‐quantitative level of expression of UGT1As revealed heterogeneous expression of i1 and i2 proteins, with increased expression of i2 in liver tumours and decreased levels of i1 and i2 in colon cancer specimens, compared to normal tissues. These differences in expression may be relevant to human colon and liver cancer tumorigenesis. Our data clearly demonstrate the similar immunolocalization of active and inactive UGT1A isoforms in most UGT1A‐expressing cell types of major tissues involved in drug metabolism. These expression patterns are consistent with a dominant‐negative function for the i2 encoded by theUGT1Agene. Copyright © 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Development of a novel, ultra‐performance polymer cement: In situ formation of benzoxazine monomer and subsequent formation of polybenzoxazine/cement composites
Authors: Ishida Hatsuo , McCoy Michelle , Bando Takamasa , Hatta Hiroshi 
Published: October 2010

AbstractThe feasibility of making a high strength, water resistant polymer cement with 6,6′‐bis(2,3‐dihydro‐3‐methyl‐4H‐1,3‐benzoxazinyl) isopropylidiene (bisphenol‐A) and methylamine‐based benzoxazine, is examined. The polymer cement composites are made by room temperature combination of monomer precursors, solvent, and alumina cement. The subsequent monomer formation, in both the presence and absence of cement, is measured with respect to time by 1H nuclear magnetic resonance spectroscopic analysis (NMR) of the reaction products. The addition of high alumina cement to the monomer precursors results in accelerated benzoxazine monomer formation at room temperature. The mechanism of monomer formation is discussed. Decreased polymerization temperature of the benzoxazine monomer in the presence of cement is studied by thermal analysis. Solvent is found to have little to no effect on the monomer formation and cure. A compressive strength as high as 250 MPa and a 90 day room temperature water absorption of less than 3% is achieved with no further addition of modifiers. POLYM. COMPOS., 2010. © 2010 Society of Plastics Engineers
Pediatric outcome of children with the prenatal diagnosis of isolated septal agenesis
Authors: Damaj L. , Bruneau B. , Ferry M. , Moutard M.‐L. , Garel C. , Odent S. , Adamsbaum C. , Avni F. , Tréguier C. , Lazaro L. 
Published: October 2010

AbstractBackgroundIsolated Septal Agenesis (SA) is a rare disease with clinical outcomes (especially neurological outcomes) that are unknown. The purpose of this study was to evaluate the clinical outcome of these children.MethodsWe conducted a retrospective multicenter study of 17 children with an isolated SA or SA combined with a moderate ventricular dilatation (VD) that was diagnosed antenatally and confirmed by a magnetic resonance imaging (MRI) performed in the antenatal period.ResultsOf the 17 children, 14 had normal neurological examinations, 2 had language development delay and visuo‐spatial dyspraxia, and 3 of the 17 children had behavioral problems. Eight children had neuropsychological evaluations, and the results were normal in six cases. There were 3 cases of septo‐optic dysplasia (SOD) diagnosed postnatally, which highlighted the difficulties in assessing the optic tract and hypothalamic‐pituitary region in antenatal imaging. Language delay and behavioral disorders were the main abnormalities at follow‐up.ConclusionThe discovery of an isolated SA reveals the difficulties of prenatal diagnosis to correlate the neurological and functional prognosis to morphological findings. The prognosis seemed to be good. It appears necessary to improve the diagnostic performance of fetal brain imaging and to follow‐up these children prospectively to assess their long‐term cognitive‐behavioral outcomes. Copyright © 2010 John Wiley & Sons, Ltd.
Modifications and applications of hyperbranched aliphatic polyesters based on dimethylolpropionic acid
Authors: Zhang Xinli 
Published: October 2010

AbstractOver the past 16 years, hyperbranched polyesters (HBPEs) based on dimethylolpropionic acid have received much attention due to their unique structural characters, their excellent physical and chemical properties as well as their potential applications in coatings, additives, drug delivery, composites, membrane science and supermolecular chemistry. HBPEs have recently become one of the types of commercialized hyperbranched polymers, and their modifications and applications are focuses of research. This paper reviews the developments in the modifications and applications of HBPEs. Copyright © 2010 Society of Chemical Industry
Structure and rheology of polypropylene with various architectures prepared by coagent‐assisted radical processing
Authors: Augier Sylvain , Coiai Serena , Passaglia Elisa , Ciardelli Francesco , Zulli Fabio , Andreozzi Laura , Giordano Marco 
Published: October 2010

AbstractThe grafting of polar monomers to polyolefin backbones carried out in the melt in the presence of peroxides is accompanied by a restructuring of the pristine macromolecule architecture depending on reaction conditions and original polyolefin structure. In the case of polypropylene (PP), side reactions, mainly degradation, are often controlled by the use of coagents which also provide a more complex scenario as far as possible reactions and final polymer structure are concerned. We have demonstrated that 2‐furyl acrylates are very active in maintaining the high molecular weight of PP during various functionalization processes carried out in the melt in the presence of peroxides. In the study reported here, PP samples modified in the melt by free radical processes initiated with peroxides in the presence of butyl‐3‐(2‐furyl) propenoate and its mixture with maleic anhydride were examined, and the effect of structural changes achieved were related to the rheology of the melt and morphological behaviour under heating. Rheological analysis is consistent with the formation of long branched macromolecules to an increasing extent with increasing content of reagents with respect to the polyolefin. Differential scanning calorimetry shows that the amount of long‐chain branching is responsible for a decrease of the melting temperature and an increase of the crystallization temperature. These results confirm that the functionalization coagent and monomer can give large macromolecule structure changes which can be driven in different directions depending on feed composition. Copyright © 2010 Society of Chemical Industry
Efficient formation of stereocomplexes of poly(L‐lactide) and poly(D‐lactide) by terminal Diels–Alder coupling
Authors: Masutani Kazunari , Kawabata Seiji , Aoki Takashi , Kimura Yoshiharu 
Published: October 2010

AbstractPoly(L‐lactide) (PLLA) and poly(D‐lactide) (PDLA) having anthracene and maleimide terminals were prepared and mixed together to induce a terminal Diels–Alder reaction providing PLLA–PDLA diblock copolymers. The resultant Diels–Alder adducts showed a sole melting peak of stereocomplex crystals around 220 °C without homochiral crystallization. In addition to their highly improved stereocomplex formation, the adducts showed no decomposition due to the retro Diels–Alder reaction below the melting temperature of the stereocomplex crystals. Copyright © 2010 Society of Chemical Industry
Explosive Mixture for Explosive Welding of Thin Foils
Authors: Andreevskikh Leonid A. , Dendenkov Yu. P. , Drennov Oleg B. , Mikhailov Anatoly L. , Titova Nadezhda N. , Deribas Andrey A. 
Published: October 2010

AbstractAn explosive mixture of PETN and baking soda has been investigated. It was found that the size of the PETN particles had crucial influence on the detonation properties of these explosives. The suggested mix of explosives can be recommended for use in explosive welding.
Migration and everyday matters: Sociality and materiality
Authors: Ho Elaine Lynn‐Ee , Hatfield (née Dobson) Madeleine E. 
Published: October 2010

AbstractIn order to provide a framework for the four papers in this special issue, this editorial foregrounds the relevance of studying migration from the perspective of everyday matters. We examine the multiple and overlapping meanings associated with the idea of the everyday and what these conceptualisations offer to migration studies. In particular, we suggest that understanding sociality and materiality as part of the experience of migration can help to illuminate migrants' everyday experiences as well as refine accepted notions of the everyday. We introduce how the papers engage with the social relations and material cultures that constitute experiences of migration in different contexts and via a variety of methodologies that lend insights into understandings of migration. In the conclusion we reflect on some of the ways in which studying the everyday can help to inform not just academic agendas but also policy and community programmes in order to better address migrants' experiences and needs. Copyright © 2010 John Wiley & Sons, Ltd.
Control of number of graphene layers grown by chemical vapor deposition
Authors: Rybin Maxim G. , Pozharov Anatoliy S. , Obraztsova Elena D. 
Published: October 2010

AbstractHere we report the data on the few layer graphene films grown by a chemical vapour deposition on nickel foils and transferred onto desirable substrates for different applications. The experimental conditions have been optimized to prepare a really single graphene layer. A strong influence of the growth conditions onto the number of graphene layers has been revealed. Raman spectroscopy was used to confirm the formation of the single graphene layer with a little amount of defects. To estimate a transmittance of graphene films the optical absorption spectra have been measured. A number of graphene layers in different samples has been estimated on the base of an optical absorbance of a monolayer graphene (2.3% of the incident light intensity). (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Large sample inference for an assay quality measure used in high‐throughput screening
Authors: Majumdar Antara , Stock David 
Published: October 2010

AbstractThe Z′ factor, introduced by Zhang et al. (J. Biomol. Screening 1999; 4(10):67–73), is used extensively in drug discovery for evaluating the performance of high‐throughput screening (HTS) assays. These assays are time consuming and expensive. Important decisions regarding HTS assay development, validation and quality are often based solely on point estimates of Z′. Although it would be beneficial to have a confidence interval for Z′, it appears that a formal inferential procedure has not yet been proposed. We fill this gap in the literature by deriving a large sample interval estimator for Z′. Simulation studies found that the proposed confidence interval performed well with both independent and moderately correlated data. Our confidence interval is algebraically simple and amenable to spreadsheet programming. The new interval allows researchers to explicitly consider the variability of estimation when making decisions based on Z′. Copyright © 2010 John Wiley & Sons, Ltd.
Nested autonomy for unmanned marine vehicles with MOOS‐IvP
Authors: Benjamin Michael R. , Schmidt Henrik , Newman Paul M. , Leonard John J. 
Published: October 2010

AbstractThis document describes the MOOS‐IvP autonomy software for unmanned marine vehicles and its use in large‐scale ocean sensing systems. MOOS‐IvP is composed of two open‐source software projects funded by the Office of Naval Research. MOOS provides a core autonomy middleware capability, and the MOOS project additionally provides a set of ubiquitous infrastructure utilities. The IvP Helm is the primary component of an additional set of capabilities implemented to form a full marine autonomy suite known as MOOS‐IvP. This software and architecture are platform and mission agnostic and allow for a scalable nesting of unmanned vehicle nodes to form large‐scale, long‐endurance ocean sensing systems composed of heterogeneous platform types with varying degrees of communications connectivity, bandwidth, and latency. © 2010 Wiley Periodicals, Inc.