bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seafloor geomorphology of the Wrigley Gulf shelf, Amundsen Sea, West Antarctica, reveals two different phases of glaciation
Authors: Lee Jae Il , Hillenbrand Claus‐Dieter , Wellner Julia S. , Kim Hyoung Jun , Rhee Hyun Hee , Yoo Kyu‐Cheul , Kim Sunghan , Lee Min Kyung 
Published: May 2024

AbstractKnowledge of the behaviour of marine‐based ice sheets during times of climatic warming, such as the last deglaciation, provides important information to understand how ice sheets respond to external forcing. We analysed swath bathymetric and acoustic sub‐bottom profiler data from Wrigley Gulf on the western Amundsen Sea shelf, West Antarctica, to identify glacial features and reconstruct past changes in the extent of the West Antarctic Ice Sheet (WAIS) and ice flow directions. Glacial bedforms mapped within a bathymetric cross‐shelf trough include features showing cross‐cutting and overprinting relationship and indicate changes in ice‐flow orientation. Here, we distinguish at least two phases of different ice‐flow patterns on the Wrigley Gulf shelf. During the earlier phase, seaward ice stream flow on the inner shelf was deflected towards the east due to the existence of an ice dome on the middle‐outer continental shelf. Retreat of grounded ice towards the centre of this dome is indicated by the asymmetric cross profile of recessional moraines mapped on the middle shelf. The later glaciation phase was characterized by fast, NNW‐directed ice flow across the shelf along a broad front and subsequent stepwise landward retreat, which is evident from the common occurrence and orientation of mega‐scale glaciation lineations and grounding zone wedges on the middle‐inner shelf. It is uncertain whether the two phases of glaciation recorded on the seafloor occurred during the last and penultimate glacial periods or at different times of the last glaciation. Reliable chronological constraints from sediment cores and additional geomorphological information are needed to understand the cause of the changes in WAIS dynamics reflected by the two ice‐flow phases.
Size‐dependent asymmetry of barchans indicates dune growth controlled by basal area or bulk volume
Authors: Robson Dominic T. , Baas Andreas C. W. 
Published: May 2024

AbstractWe introduce a novel analytical model of the growth of barchan dunes in terms of their two flanks, from which we derive expressions for the size‐dependence of the bilateral asymmetry of these bedforms in three cases where different mechanisms dominate the growth process. Analysis of the morphology of barchans on Mars and Earth suggest that there may exist two distinct attractor states for the asymmetry distribution. By comparing our analytical results with the observations, we show that the growth of barchan dunes appears to be dominated by processes, which are proportional to the basal area or volume of the bedforms, rather than being linear to their width as is typically assumed. We propose hypotheses explaining area‐dominated growth as a result of variable wind regimes and volume‐dominated growth from collisions. These predictions appear to be in line with the available data for the terrestrial swarms and barchan‐like submarine bedforms and offer the potential of predicting patterns in inaccessible wind regimes from data on the morphology of the dunes.
Effect of different cooking conditions on the quality characteristics of chicken claws
Authors: Yu Yifan , Yuan Xianling , Zhang Zhouyou , Zheng Yidan , He Ying , Zhou Yingru 
Published: May 2024

AbstractChicken claw products with their unique texture are loved by consumers, and cooking is a key step to affect the taste of chicken claw consumption, through the moderate hydrolysis of proteins and a series of physicochemical changes, so that the chicken claw gets tender and presents a crispy taste, but the current research on the optimal cooking conditions for chicken claw is still relatively small. In the present work, combinations of time (11, 13, 15, 17, and 19 min) and temperature (82, 86, 90, 94, and 98°C) were applied to the cooking of chicken claws. The effects of different cooking conditions on the quality characteristics of chicken claws were investigated, with special emphasis on the cooking loss rate, color, texture properties, lipid oxidation, myofibrillar fragmentation index (MFI), and total sulfhydryl content. The results showed that the cooking loss rate, lipid oxidation, and MFI value of chicken claws gradually increased, and the total color difference (∆E), puncture force, shear force, and total sulfhydryl content gradually decreased with the increase of cooking temperature and cooking time. Overall, chicken claws cooked at 86, 90, and 94°C for 15 and 17 min had better texture and flavor.
Myomucosal composite graft: A simple technique for full‐thickness vermilion defects of the lower lip
Authors: Lee Kyu‐Il , Han Seung‐Kyu , Jeong Seong‐Ho , Dhong Eun‐Sang 
Published: May 2024

AbstractReconstruction of vermillion defects of the lower lip requires careful consideration of functional and aesthetic aspects. Traditionally, various local flap methods involving tissue advancement from the corner of the mouth, lateral chin, and medial cheek have been commonly employed to fill lower lip defects. However, these approaches have inherent limitations, which include technical complexity, disruption of the orbicularis oris muscle, lip tightening, microstomia, and visible scarring. To overcome these limitations, we employed a free myomucosal composite graft from the lower lip to reconstruct small to medium vermilion defects. Our technique is based on a simple and reproducible surgical approach that facilitates natural volume rearrangement of tissues. Moreover, this method enables precise inset and tension‐free repair, prevents lip tightening, and offers excellent aesthetic outcomes with no vertical scarring and appropriate color matching with surrounding tissues.
Ambrox through the Looking Glass: Chemoenzymatic Synthesis and GC‐Olfactometric Analysis of 15 Ambrox Stereoisomers
Authors: Flachsmann Felix , Aeberli Natalie , Dossenbach Sandro , Hortencio Lucas , Koch Heinz , Brunner Gerhard , Spenger Benjamin , Eichhorn Eric , Fonzo Alessio , Berweger Raphael , Lelièvre Dominique 
Published: May 2024

AbstractAll eight theoretical stereoisomers of (10S)‐Ambrox have been synthesized by enzymatic polycyclization of the four geometric isomers of homofarnesol with selected squalene hopene cyclases. This includes the highly strained (+)‐(8S,9S)‐Ambrox, an isomer historically considered unlikely to exist. The enantiomeric (10R)‐series has been prepared by a combination of diastereoselective synthesis and preparative chiral HPLC. Thus, for the first time, the synthesis and sensory properties of all but one stereoisomers of Ambrox are presented. The results solve a long standing peradventure: the commercial product (−)‐Ambrox exhibits by far the strongest odour, the previously described 9‐epi‐Ambrox is 26 times weaker. The enantiomer difference between (−)‐and (+)‐Ambrox was also found much higher than in previous reports (1000 vs. 8 times). The (8R)‐configuration was identified as the single most important structural feature for high odour strength.
Identifying modifiable risk factors to prevent aggressive colorectal cancer
Authors: Wang Peilu , Song Mingyang , Eliassen A. Heather , Wang Molin , Chan Andrew T. , Meyerhardt Jeffrey A. , Tabung Fred K. , Zhang Xuehong , Ugai Tomotaka , Ogino Shuji , Giovannucci Edward L. 
Published: May 2024

AbstractIt remains unclear if pre‐diagnostic factors influence the developmental pathways of colorectal cancer (CRC) that could enhance tumor aggressiveness. This study used prospective data from 205,489 cancer‐free US health professionals to investigate the associations of 31 known or putative risk factors with the risk of aggressive CRC. Tumor aggressiveness was characterized by three endpoints: aggressive CRC (cancer that causes death within 5 years of diagnosis), fatal CRC, and tumor stage at diagnosis. The data augmentation method was used to assess the difference in the associations between risk factors and endpoints. We documented 3201 CRC cases, of which 899 were aggressive. The protective associations of undergoing lower endoscopy (hazard ratios [HR] 0.43, 95% confidence interval (CI) 0.37, 0.49 for aggressive versus HR 0.61, 95% CI 0.56, 0.67 for non‐aggressive) and regular use of aspirin (HR 0.70, 95% CI 0.61, 0.81 versus HR 0.84, 95% CI 0.77, 0.92) were stronger for aggressive than non‐aggressive CRC (pHeterogeneity <0.05). Lower intake of whole grains or cereal fiber and greater dietary inflammatory potential were associated with a higher risk of aggressive but not non‐aggressive CRC. The remaining risk factors showed comparable associations with aggressive CRC and non‐aggressive CRC. Aggressive cases were more likely to have KRAS‐mutated tumors but less likely to have distal or MSI‐high tumors (p < .007). Similar results were observed for fatal CRC and advanced tumor stages at diagnosis. These findings provide initial evidence for the role of pre‐diagnostic risk factors in the pathogenesis of aggressive CRC and suggest research priorities for preventive interventions.
Uterine lithiasis, management by hysteroscopy: Case report and literature review
Authors: Sepúlveda Agudelo Janer , Torres Lucero Andrés Sebastián , Sepúlveda Sanguino Andrea Juliana 
Published: May 2024

AbstractThe presence of calculi inside the uterine cavity is an uncommon finding, with few cases described in the literature. Here, we present a clinical case of a 30‐year‐old patient with uterine lithiasis. The patient presented with 3 months of evolution, characterized by abdominal pain in the hypogastrium, with a report of transvaginal ultrasound of hematometra with suggestive images of endometrial polyps. For this reason, she was scheduled for hysteroscopy, where three lesions of hard consistency were found, with the largest 1.5 cm. Currently, due to the few cases of uterine lithiasis described, there is no explanation of how the stones are formed in the uterine cavity. The age of the patient in this case report and the absence of predisposing factors for uterine calcifications reported in the literature is striking, which leads us to propose a hypothesis of the origin of uterine lithiasis, which is related to the history of cesarean section and the presence of hematometra, such hematic retention could have predisposed to the development of calculi in this patient. Uterine lithiasis is an extremely rare entity with few published cases; therefore, further studies are necessary.
Exposure of cinnamyl alcohol in co‐culture of BEAS‐2B and dendritic cells: Interaction between CYP450 and cytokines
Authors: Yoshizaki Kelly , Frias Daniela Perroni , Maier Kevin , Smelan Juliana , Correia Aristides Tadeu , Oliveira Luanda Mara da Silva , Amato‐Lourenço Luís Fernando , Santillo Bruna Tereso , Prado Carla Máximo , Oshiro Telma Miyuki , Barbuto Jose Alexandre M. , Mauad Thais , Macchione Mariangela 
Published: May 2024

AbstractThe prevalence of fragrances in various hygiene products contributes to their sensorial allure. However, fragrances can induce sensitization in the skin or respiratory system, and the mechanisms involved in this process are incompletely understood. This study investigated the intricate mechanisms underlying the fragrance's effects on sensitization response, focusing on the interplay between CYP450 enzymes, a class of drug‐metabolizing enzymes, and the adaptive immune system. Specifically, we assessed the expression of CYP450 enzymes and cytokine profiles in culture of BEAS‐2B and mature dendritic cells (mDC) alone or in co‐culture stimulated with 2 mM of a common fragrance, cinnamyl alcohol (CA) for 20 h. CYP1A1, CYP1A2, CYP1B1, CYP2A6, and CYP2A13 were analyzed by RT‐PCR and IL‐10, IL‐12p70, IL‐18, IL‐33, and thymic stromal lymphopoietin (TSLP) by Cytometric Bead Array (CBA). Through RT–PCR analysis, we observed that CA increased CYP1A2 and CYP1B1 expression in BEAS‐2B, with a further increased in BEAS‐2B‐mDC co‐culture. Additionally, exposure to CA increased IL‐12p70 levels in mDC rather than in BEAS‐2B‐mDC co‐culture. In regards to IL‐18, level was higher in BEAS‐2B than in BEAS‐2B‐mDC co‐culture. A positive correlation between the levels of IL‐10 and CYP1B1 was found in mDC‐CA‐exposed and between IL‐12p70 and CYP1A1 was found in BEAS‐2B after CA exposure. However, IL‐12p70 and CYP1A2 as well as IL‐18, IL‐33, and CYP1A1 levels were negative, correlated mainly in co‐culture control. These correlations highlight potential immunomodulatory interactions and complex regulatory relationships. Overall, exposure to CA enhances CYP450 expression, suggesting that CA can influence immune responses by degrading ligands on xenosensitive transcription factors.
Beyond life: Exploring hemodynamic patterns in postmortem mice brains
Authors: Sdobnov Anton , Tsytsarev Vassiliy , Piavchenko Gennadi , Bykov Alexander , Meglinski Igor 
Published: May 2024

AbstractWe utilize Laser Speckle Contrast Imaging (LSCI) for visualizing cerebral blood flow in mice during and post‐cardiac arrest. Analyzing LSCI images, we noted temporal blood flow variations across the brain surface for hours postmortem. Fast Fourier Transform (FFT) analysis depicted blood flow and microcirculation decay post‐death. Continuous Wavelet Transform (CWT) identified potential cerebral hemodynamic synchronization patterns. Additionally, non‐negative matrix factorization (NMF) with four components segmented LSCI images, revealing structural subcomponent alterations over time. This integrated approach of LSCI, FFT, CWT, and NMF offers a comprehensive tool for studying cerebral blood flow dynamics, metaphorically capturing the ‘end of the tunnel’ experience. Results showed primary postmortem hemodynamic activity in the olfactory bulbs, followed by blood microflow relocations between somatosensory and visual cortical regions via the superior sagittal sinus. This method opens new avenues for exploring these phenomena, potentially linking neuroscientific insights with mysteries surrounding consciousness and perception at life's end.
Lead independent director reputation incentives and audit fees
Authors: Bryan David B. , Mason Terry W. 
Published: May 2024

AbstractAlthough prior research has recently begun to examine the effects of independent director reputation incentives and the benefits of having a lead independent director, no study has considered the combined impact: the reputation incentives of lead independent directors. This study integrates these emerging streams of research to investigate whether the reputation incentives of lead independent directors affect audit fees. We find that firms with a lead independent director who has relatively low reputation incentives are associated with audit fees that are 4.39% higher than firms with a lead independent director who has neutral reputation incentives, consistent with auditors viewing these firms as riskier. We also find that this association is driven by auditors who are not industry specialists. Our results continue to hold when using an entropy balancing approach and when conducting other robustness tests.
Characterization and correlations of dominant microorganisms and volatile compounds in fermentation process of Yangjiang douchi
Authors: Zhang Jing , Han Zhuoxuan , Chen Haitao , Wang Shuqi , Sun Jie , Zhang Ning , Zhang Huiying 
Published: May 2024

AbstractBACKGROUNDYangjiang douchi (YD) is a traditional fermented soybean product, which is popular in Chinese cuisine for its unique flavor. However, due to its high salt content and unstable flavor, its competitiveness in the international market is gradually weakening. Microorganisms have a key role in the production process of YD because it is a fermented food but the effect of microorganisms on the volatile compounds of YD is also not currently clear.RESULTSIn this paper, aroma compounds and microbial diversity in different fermentation stages of YD were analyzed using gas chromatography–mass spectrometry/olfactometry (GC–MS/O) and IlluminaMiseq system sequencing. A total of 78 aroma‐active compounds were detected throughout the fermentation process and they influenced the formation of flavor in YD. Fungi flora were relatively single in YD, and bacteria were rich and varied. A total of 418 species of bacteria were present during fermentation, with unclassified_Staphylococcus, Staphylococcus_kloosii, and Bacillus_velezensis_Bacillus predominating. There were 25 species of fungi at the species level, and Aspergillus minisclerotigenes (OTU 4) played a dominant role in the whole fermentation process.CONCLUSIONStaphylococcus and Bacillus in the bacterial genus were strongly correlated with most flavor compounds detected, and A. minisclerotigenes in the fungi were more relevant to flavor compounds. This research provides a theoretical basis for the enhancement of the flavor of traditional fermented douchi in China. © 2024 Society of Chemical Industry.
47.5‐inch 8K inkjet printing AMOLED monitor with local boosting gate driver on array design
Authors: Hsu Minghung , Fan Zhaokang , Wang Huifeng , Yuan Can , Yuan Zhidong , Wei Xiaolong , Liu Jun , Zhao Ce , Cheng Xuelian , Yan Guang , Yan Liangchen , Li Yongqian , Li Sun , Shih Huaiting , Yu Jianwei , Dong Xue 
Published: May 2024

AbstractIn this paper, we presented a 47.5 in. 8K2K AMOLED MNT employing a low temperature poly‐silicon (LTPS) backplane, top emissive inkjet printing (IJP) OLED devices, and gate driver on array (GOA) supporting independent 32 * 9 zone control and internal compensation driving. By combining printed RGB units with a common evaporative blue stack, we proposed the hybrid tandem IJP devices that improved both device efficiency and operation load balance. In the local boosting GOA design, a novel architecture for independent display partition control was developed. The GOA cascading and timing scheme was carefully considered by reusing several clock signals to support both TFT internal compensation and display zone control. It is so far the first prototype AMOLED MNT integrating inkjet printing process and local high frame rate (up to 960 Hz) driving. Thanks to the 8K2K high resolution, local frame rate data processing, and IJP OLED EL reaching HDR brightness up to 580 nits with superior optical performance, it shows a brand‐new approach to deliver a premium display.
Nutritional Composition, Bioactive Compounds, Food Applications, and Health Benefits of Pigeon Pea (Cajanus cajan L. Millsp.): A Review
Authors: Haji Abdulmajid , Teka Tilahun A. , Yirga Bereka Tizazu , Negasa Andersa Kumsa , Desalegn Nekera Kasahun , Geleta Abdi Gemechu , Lema Abelti Alemu , Makiso Urugo Markos 
Published: May 2024

ABSTRACTPigeon pea is one of the most multipurpose grain legumes in the tropical and subtropical world. It is highly resilient to climate change due to drought tolerance. It ranks sixth following common beans, chickpeas, field peas, cowpeas, and lentils globally. Pigeon pea is an excellent source of high‐quality protein, essential amino acids, and minerals. Furthermore, pigeon pea is endowed with valuable water‐soluble vitamins such as thiamin, ascorbic acid, riboflavin, and niacin. With low levels of saturated fat and sodium and being cholesterol free, pigeon peas emerge as a nutritious dietary choice. Pigeon peas are rich sources of bioactive compounds with various potential health properties, including anti‐inflammatory, antibacterial, antioxidant, anticarcinogenic, and antidiabetic effects. Pigeon peas can be consumed in diverse forms, including whole seeds, split seeds (known as dhal), vegetables using green seeds, and fresh pods. Moreover, pigeon peas find application in a variety of food products, including bread, pasta, noodles, snacks, and biscuits. Despite their nutritional and medicinal properties, pigeon peas remain among the least utilized legumes globally. This review paper aims to provide up‐to‐date information on the nutritional compositions, bioactive compounds, food applications, and health benefits of pigeon peas.
Species richness and intraspecific variation interactively shape marine diatom community functioning
Authors: Thomas Patrick K. , Jacob Marrit , Acevedo‐Trejos Esteban , Hillebrand Helmut , Striebel Maren 
Published: May 2024

AbstractBiodiversity generally increases productivity in ecosystems; however, this is mediated by the specific functional traits that come with biodiversity loss or gain and how these traits interact with environmental conditions. Most biodiversity studies evaluate the effects of species richness alone, despite our increasing understanding that intraspecific diversity can have equally strong impacts. Here, we manipulate both species richness and intraspecific richness (i.e., number of distinct strains) in marine diatom communities to explicitly test the relative importance of species and strain richness for biomass and trait diversity in six distinct temperature/nutrient environments. We show that species and strain richness both have significant effects on biomass and growth rates, but more importantly, they interact with each other, indicating that cross‐species diversity effects depend on within‐species diversity and vice versa. This intertwined relationship thus calls for more integrative approaches quantifying the relative importance of distinct biodiversity components and environmental context on ecosystem functioning.
A POLICY ENTREPRENEUR’S EIGHT‐STEP GUIDE TO TURN IDEAS TO IMPACT
Authors: Sheldrick Michael 
Published: May 2024

AbstractSheldrick, the co‐founder of Global Citizen, writes about “how to bring about meaningful change in today’s divided world.” He discusses the concept of the policy entrepreneur, which he says is “a term coined by political scientist John Kingdon.” Sheldrick’s eight steps of policy entrepreneurship are, in his words, (1) Know your policy goal (2) Know which stakeholders matter and how to influence them (3) Mastering the art of timing (4) Mastering the art of storytelling (5) Embrace pragmatic idealism (6) Leveraging your partners’ strengths (7) Know your endgame (8) Communicate stories of success. Within step one: “A well‐defined policy goal is a linchpin that turns good intentions, such as halting illegal deforestation or curbing the spread of infectious diseases, into impactful change.” In step two: “To drive effective change, you must go where those in power meet.” In step three: “Effective policy entrepreneurs identify the opportune moment to advocate for their policy goal and proactively explore ways to expand its acceptability.” In step four: “To craft a memorable story, emphasize the “why” to build trust and provide practical solutions—the “how” —for a chaotic world.”
Crossmodal compensation: Sensory discomfort affects consumer preferences across modalities
Authors: Groth Oden H. , Hadi Rhonda , Block Lauren 
Published: May 2024

AbstractConsumers are frequently exposed to uncomfortable sensory circumstances (e.g., hot weather and noise pollution), yet little research has examined how such discomfort might systematically shape preferences. Drawing from research on crossmodal associations, we propose and empirically support a discomfort‐driven crossmodal compensation effect in which consumers exposed to uncomfortable atmospheric sensations in one modality (e.g., loud noise) compensate through product choices across other modalities (e.g., choosing visually “quiet” products). Across five studies, we document the consequences of this phenomenon on actual (studies 1 and 2) and hypothetical (studies 3, 4, and 5) consumer choices and preferences. Further, we demonstrate that a desire to reduce sensory discomfort drives this crossmodal compensation effect, and the spillover only manifests when individuals are unable to adjust within the initially disturbed modality. Our research contributes to the literature on goal theory and crossmodal associations by demonstrating that discomfort experienced in one modality can systematically affect product preferences in other modalities.