bluuebunny/crossref_metadata_2025_split huggingface dataset:
The paclitaxel‐eluting coroflex™ please stent study (PECOPS I): The 3‐year clinical follow‐up
Authors: Unverdorben Martin , Degenhardt Ralf , Wiemer Marcus , Horstkotte Dieter , Schneider Henrik , Nienaber Christoph , Bocksch Wolfgang , Gross Michael , Boxberger Michael , Vallbracht Christian 
Published: April 2009

AbstractBackground: The evaluation of drug‐eluting devices in humans should include longterm follow‐up owing to risk of late target vessel thrombosis with the possible fatal sequel. Methods and Results: Therefore, the three‐year clinical outcome of the paclitaxeleluting Corofiex® Please stent in patients with de‐novo coronary lesions was evaluated in the single‐arm PECOPS I pilot study. The clinical data of 123/125 (98.4%) of all patients included were available 3.05 ± 0.12 years following stent deployment. In the intention‐to‐treat analysis the incidence of cardiac death was 9/123 (7.3%), of myocardial infarction 4/123 (3.3%), and of in‐segment target lesion revascularization 14/123 (11.4%). Target lesion revascularizations tended (p = 0.30) to occur less frequently (9/96 (16.6%)) in those patients in whom the stent length was longer than the lesion (4.80 ± 2.71 mm) compared to 5/27 (18.5%) in those patients in whom the stent was shorter than the lesion (−3.0 ± 2.43 mm). Stent thromboses occurred in 2/123 (1.6%) patients during the first 6 months, one of which two days after premature discontinuation of clopidogrel. The total 3‐year MACE rate was 22/123 (17.9%). Conclusion: The present study describes the paclitaxel‐eluting Corotlex Please stent as a safe device with good long term performance when deployed in native coronary arteries. The occurrence of late major adverse events and late thromboses in particular seem to be very low. © 2009 Wiley‐Liss, Inc.
Coronary revascularization for patients with unprotected left main coronary artery disease: Evidence, guidelines, and judgment! making clinical decisions in 2009
Authors: Moussa Issam D. , Wong S. Chiu , Feldman Ted 
Published: April 2009

AbstractThe current clinical practice guidelines categorize the use of coronary artery bypass graft (CABG) surgery for revascularization of patients with unprotected left main coronary artery disease (ULMCAD) as a class IA recommendation while it categorize the use of percutaneous coronary interventions (PCI) as a class III recommendation. The evidence underlying these recommendations is weak and out dated. The purpose of this review is to critically reevaluate current state‐of‐the‐art with respect to revascularization of patients with ULMCAD who are acceptable surgical candidates. In doing so we will highlight the divergence between practice guidelines and patient‐centered clinical decision‐making; critically appraise the “evidence” underlying the current practice guidelines; review the emerging data regarding utility of CABG versus PCI in these patients; and finally discuss the elements of a contemporary approach to clinical decision‐making in light of the current state of knowledge. © 2009 Wiley‐Liss, Inc.
Deep‐vein thrombosis in malignancy: How long should patients be treated, and with what?
Authors: Merli Geno J. 
Published: April 2009

AbstractCancer patients are at high‐risk of venous thromboembolism (VTE). However, the optimal VTE prophylaxis and treatment options for this population are currently unclear. Surgical cancer patients have been shown to benefit from pharmacological VTE prophylaxis, with a number of trials suggesting that prophylaxis duration should extend beyond the traditional 7 day period. Medical (nonsurgical) cancer patients are also at high‐risk of VTE, and evidence‐based guidelines recommend pharmacological VTE prophylaxis in hospitalized cancer patients who are bedridden. In cancer patients with confirmed VTE, questions remain over the most effective long‐term treatment regimen. Further trials are required to help physicians to make evidence‐based choices for the management of VTE in these patients. © 2009 Wiley‐Liss, Inc.
Factors influencing changes in employment among women with newly diagnosed breast cancer
Authors: Hassett Michael J. , O'Malley A. James , Keating Nancy L. 
Published: April 2009

AbstractBACKGROUND:Although studies have demonstrated that women are less likely to work after they are diagnosed with breast cancer, the influence of cancer treatments on employment is less clear. The authors of this report assessed whether chemotherapy or radiation therapy was associated with a disruption in employment during the year after a breast cancer diagnosis.METHODS:Using a database of health insurance claims that covered 5.6 million US residents, 3233 women aged ≤63 years were identified who were working full time or part time when they were diagnosed with breast cancer between 1998 and 2002. All changes in employment during the year after a breast cancer diagnosis were identified. Using a Cox proportional hazards model that incorporated time‐varying treatment variables, the authors evaluated the impact of chemotherapy and radiation therapy on the likelihood of experiencing an employment disruption.RESULTS:Although most women (93%) continued to work, chemotherapy recipients were more likely than nonrecipients to go on long‐term disability, stop working, or retire (hazards ratio, 1.8; P < .01). Women aged ≥54 years were more likely to experience a change in employment than women aged ≤44 years (P < .01). Radiation therapy did not influence employment (P = .22).CONCLUSIONS:In this population of employed, insured women, chemotherapy had a negative impact on employment. This finding may aid treatment decision making and could foster the development of interventions that support a patient's ability to continue working after treatment. It also reinforces the need to assess the impact of treatments, especially new treatments, on patient‐centered outcomes such as employment. Cancer 2009. © 2009 American Cancer Society.
Prognostic significance of carbonic anhydrase IX expression by cancer‐associated fibroblasts in lung adenocarcinoma
Authors: Nakao Masayuki , Ishii Genichiro , Nagai Kanji , Kawase Akikazu , Kenmotsu Hirotsugu , Kon‐no Hidehiro , Hishida Tomoyuki , Nishimura Mitsuyo , Yoshida Junji , Ochiai Atsushi 
Published: April 2009

AbstractBACKGROUND:Cancer tissue is comprised of cancer cells and several types of stromal cells, including cancer‐associated fibroblasts (CAFs). Carbonic anhydrase (CA) IX has been used as an endogenous hypoxia marker, and although its expression by cancer cells has been reported to be associated with a poor outcome in a board range of tumors, to the authors' knowledge, the biologic significance of its expression by CAFs remains unclear.METHODS:The authors investigated CA IX expression by CAFs and cancer cells immunohistochemically in 158 consecutive resected cases of lung adenocarcinoma.RESULTS:CA IX was expressed by CAFs in 39 (24.7%) of the 158 cases and by cancer cells in 40 (25.3%) cases. CA IX expression by CAFs was found to be significantly correlated with conventional prognostic factors, including pathologic tumor classification and lymph node involvement. A univariate analysis and the log‐rank test demonstrated a significant association between CA IX expression by CAFs (P = .006 and P = .0052, respectively) and by cancer cells (P = .020 and P = .0179, respectively) with lower survival rate. A multivariate analysis of these 2 factors indicated a statistically significant association between CA IX expression by CAFs and a lower survival rate (hazards ratio [HR], 1.797; P = .032), but not between expression by cancer cells and lower survival rate (HR, 1.561; P = .102).CONCLUSIONS:The findings of the current study indicate that CA IX expression by CAFs was a better predictor of outcome than CA IX expression by cancer cells and provides new insights into the biologic significance of CAFs in the hypoxic microenvironment of the lung adenocarcinoma. Cancer 2009. © 2009 American Cancer Society.
SALL4 is a novel sensitive and specific marker for metastatic germ cell tumors, with particular utility in detection of metastatic yolk sac tumors
Authors: Cao Dengfeng , Humphrey Peter A. , Allan Robert W. 
Published: April 2009

AbstractBACKGROUND:The correct diagnosis of metastatic germ cell tumors is critical, because these tumors can be effectively treated and are even cured with modern therapy. Their histopathologic diagnosis can be challenging without immunohistochemical markers, which currently have limitations. SALL4 is a novel stem cell marker essential to maintain pluripotency and self‐renewal of embryonic stem cells. In the current study, the authors investigated the utility of SALL4 as a potential diagnostic marker for metastatic germ cell tumors.METHODS:Ninety metastatic germ cell tumors from testis, ovary, and extragonadal sites were stained with a monoclonal SALL4 antibody. In addition, 170 metastatic nongerm cell malignancies, including 158 carcinomas (6 head and neck, 8 thyroid, 12 lung, 8 breast, 7 hepatocellular, 3 cholangiocarcinomas, 2 ampullary, 10 pancreatic, 18 gastric, 15 esophageal, 10 renal cell, 10 urothelial, 12 prostatic, 18 ovarian, 6 uterine, and 13 colonic) and 12 melanomas, were also stained to test SALL4 specificity.RESULTS:All 22 seminomas, 7 dysgerminomas, 22 embryonal carcinomas, and 14 of 15 yolk sac tumors displayed strong and diffuse SALL positivity in >90% of tumor cells (80% of tumor cells were strongly positive in the remaining yolk sac tumor). Five of 7 choriocarcinomas and 9 of 18 teratomas were also variably positive for SALL4. In contrast, only 10 (esophageal, gastric, and colonic adenocarcinomas) of 170 metastatic somatic tumors demonstrated focally weak SALL4 reactivity (<25% tumor cells).CONCLUSIONS:SALL4 is a novel sensitive and highly specific marker for metastatic germ cell tumors, and is particularly useful for detecting metastatic yolk sac tumors. Cancer 2009. © 2009 American Cancer Society.
Human papillomaviruses are identified in a subgroup of sinonasal squamous cell carcinomas with favorable outcome
Authors: Alos Llucia , Moyano Susana , Nadal Alfons , Alobid Isam , Blanch Jose L. , Ayala Edgar , Lloveras Belén , Quint Wim , Cardesa Antonio , Ordi Jaume 
Published: April 2009

AbstractBACKGROUND:The role of human papillomavirus (HPV) in the pathogenesis of squamous cell carcinomas (SCCs) of the sinonasal tract and its clinicopathological implications were evaluated.METHODS:All SCCs of the sinonasal tract diagnosed in the Hospital Clinic of Barcelona from 1981 to 2006 were retrospectively evaluated (N = 60). Clinical and pathological data were reviewed. HPV infection was determined and typed by amplification of HPV DNA by polymerase chain reaction using the SPF‐10 primers. p16INK4a expression was determined by immunohistochemistry. Overall and progression‐free survival for HPV‐positive and ‐negative patients was estimated by Kaplan‐Meier analysis and by the use of a multivariate Cox proportional hazards model.RESULTS:HPV DNA was detected in tumor tissue of 12 of 60 (20%) patients. HPV16 was identified in 11 tumors and HPV35 in 1. Immunohistochemistry for p16INK4a stained all HPV‐positive and no HPV‐negative tumors (P < .001). No differences were observed in terms of site and histological grade or stage at presentation between HPV‐positive and ‐negative tumors. However, HPV‐positive patients had a significantly better 5‐year progression‐free survival (62%; 95% confidence interval [CI], 23%‐86% vs 20%; 95% CI, 9%‐34%; P = .0043, log‐rank test) and overall survival (80%; 95% CI, 20%‐96% vs 31%; 95% CI, 15%‐47%; P = .036, log‐rank test) than patients with HPV‐negative tumors. In multivariate analysis, HPV‐positive tumors were associated with improved progression‐free survival (hazard ratio, 0.21; 95% CI, 0.17‐0.98; P = .012).CONCLUSIONS:A subgroup of sinonasal SCCs is associated with HPV infection. These tumors have a significantly better prognosis. Cancer 2009. © 2009 American Cancer Society.
Cystic pancreatic endocrine tumors
Authors: Charfi Slim , Marcy Myriam , Bories Erwan , Pesanti Christian , Caillol Fabrice , Giovannini Marc , Viret Fréderic , Robert Delpero Jean , Xerri Luc , Monges Genevieve 
Published: April 2009

AbstractBACKGROUND:Cystic pancreatic endocrine tumors (PETs) are rare neoplasms with a preoperative diagnostic challenge. The aim of this study was to evaluate the preoperative diagnostic strategy for these tumors and to assess the clinical and pathologic characteristics.METHODS:Six cases of cystic PET were retrospectively enrolled. Endoscopic ultrasound‐guided fine‐needle aspiration biopsy (EUS‐FNAB) was performed in 4 cases. All cytomorphologic data from conventional smears, ThinPrep preparations, and cell block preparations were reported in detail.RESULTS:There were 3 male and 3 female patients with a mean age of 52.3 years. Tumor size ranged from 10 mm to 60 mm (mean, 29.8 mm). EUS‐FNAB contributed to an accurate diagnosis in all cases. Cytologically, loosely cohesive aggregates and single cells were predominant. Cells were small and typically plasmacytoid, with occasional cytoplasmic vacuolization. Nuclei were round or oval, uniform, with finely and evenly distributed chromatin. Immunocytochemistry confirmed the endocrine differentiation. Histologic findings were typical for endocrine proliferation. All tumors were well differentiated.CONCLUSIONS:Cystic PET is an unusual finding that presents diagnostic challenges for both endoscopists and cytologists. EUS‐FNAB with the Thinprep preparation technique and cell block material were found to be helpful in improving diagnostic accuracy. Immunocytochemical staining with endocrine markers confirmed the diagnosis. Cancer (Cancer Cytopathol) 2009. © 2009 American Cancer Society.
Slow energy dissipation in anharmonic oscillator chains
Authors: Hairer Martin , Mattingly Jonathan C. 
Published: April 2009

AbstractWe study the dynamic behavior at high energies of a chain of anharmonic oscillators coupled at its ends to heat baths at possibly different temperatures. In our setup, each oscillator is subject to a homogeneous anharmonic pinning potential V1(qi) = |qi|2k/2k and harmonic coupling potentials V2(qi − qi − 1) = (qi − qi − 1)2/2 between itself and its nearest neighbors. We consider the case k > 1 when the pinning potential is stronger than the coupling potential. At high energy, when a large fraction of the energy is located in the bulk of the chain, breathers appear and block the transport of energy through the system, thus slowing its convergence to equilibrium.In such a regime, we obtain equations for an effective dynamics by averaging out the fast oscillation of the breather. Using this representation and related ideas, we can prove a number of results. When the chain is of length 3 and $k > {3 \over 2}$, we show that there exists a unique invariant measure. If k > 2 we further show that the system does not relax exponentially fast to this equilibrium by demonstrating that 0 is in the essential spectrum of the generator of the dynamics. When the chain has five or more oscillators and $k > {3 \over 2}$, we show that the generator again has 0 in its essential spectrum.In addition to these rigorous results, a theory is given for the rate of decrease of the energy when it is concentrated in one of the oscillators without dissipation. Numerical simulations are included that confirm the theory. © 2009 Wiley Periodicals, Inc.
Convergence of voices: Assimilation in linguistic therapy of evaluation
Authors: Gabalda Isabel Caro 
Published: April 2009

AbstractThis paper shows the convergence of voices in psychotherapy in the context of the assimilation model. Convergence is the link between patients' voices within the community of voices. The main aim of the paper was to explore (a) how convergence (and divergence) is shown during sessions and the usefulness of convergence for the process of assimilation; (b) if a well‐structured patient is able to track the sociohistorical antecedents of his/her main voices; and (c) if, at the end of the therapy, the self becomes richer and with more resources.For this aim to be realized, a case study of a patient, María, treated with linguistic therapy of evaluation for 14 sessions, was analysed by using the Assimilation of Problematic Experiences Scale (APES). Three main problematic experiences or non‐dominant voices were identified with the APES: inability to do things, dizziness and tiredness. María's main dominant voices were to cure, solve and overcome problems, to be always doing things and to cope.Results showed a convergence but no divergence of voices as early as session 3. Results also showed how continuity‐benevolence assumptions were broken and that, at the end of therapy, the patient's self became richer due to assimilation through the dialogue between non‐dominant and dominant voices.Discussion emphasized these results, which are especially representative of a well‐integrated patient who showed a healthy multiplicity. Copyright © 2009 John Wiley & Sons, Ltd.
Social motivation affects the display of individual discrimination in young and adult japanese quail(Coturnix japonica)
Authors: Schweitzer C. , Poindron P. , Arnould C. 
Published: April 2009

AbstractA simultaneous two‐choice test was used to investigate discrimination between a familiar (F) and an unfamiliar conspecific (U) in Japanese quail, selected for high (HSR) or low (LSR) social reinstatement behavior (tendency to rejoin and stay close to conspecifics). Animals were 1‐week unsexed and 6‐week‐old male quail. One‐week‐old LSR quail and 6‐week‐old male HSR quail displayed discrimination after 24 hr of pair contact (p < 0.05), and a tendency to discriminate (p < 0.10) was found in adult male LSR quail. After 1 week of pair contact, results were similar in LSR quail chicks, but no discrimination was evidenced in adult quail of either line. Therefore, Japanese quail are able to discriminate between a familiar cagemate and an unfamiliar conspecific after only 24 hr of pair contact. Moreover, this study reveals for the first time in this species that social motivation and age both influence the display of individual discrimination. © 2009 Wiley Periodicals, Inc. Dev Psychobiol 51: 311–321, 2009.
Examining maternal influence on OLETF rats' early overweight: Insights from a cross‐fostering study
Authors: Schroeder Mariana , Schechter Michal , Fride Ester , Moran Timothy H. , Weller Aron 
Published: April 2009

AbstractObese female Otsuka Long Evans Tokushima Fatty (OLETF) rats display increased nursing time and frequency compared to lean LETO controls, suggesting a maternal contribution to pup preobesity. In previous studies, OLETF pups presented high adiposity, showed greater suckling efficiency, initiative and weight gain from nursing than controls throughout lactation. To further elucidate maternal–infant interactions contributing to pup preobesity, we cross‐fostered pups a day after birth and examined maternal behavior. Nursing frequency decreased in OLETF dams raising LETO pups (OdLp) in the third postnatal week, while LETO dams raising OLETF pups showed no significant changes. Fat % was greater in the milk of OLETF versus LETO dams. OdLp pups showed long‐term body weight (BW) increase, suggesting that maternal environment can induce BW increases even in the absence of a genetic tendency. Additionally, interaction between OLETF dams and pups produces high nursing frequency, exposing the pups to abundant high‐fat milk, thus strengthening their preobese phenotype. © 2009 Wiley Periodicals, Inc. Dev. Psychobiol 51: 358–366, 2009.
Maternal care affects the development of maternal behavior in inbred mice
Authors: Shoji Hirotaka , Kato Katsunori 
Published: April 2009

AbstractThe present study investigated the effects of variations in maternal behavior on the development of maternal behavior of female offspring in BALB/c and CBA/Ca inbred mice. In Experiment 1, we conducted fostering within or between the two strains and observed the maternal behaviors of mothers and female offspring for 2 weeks postpartum. Although fostering changed the maternal behavior of mothers in both strains, CBA mothers generally showed greater frequency of nursing posture and pup licking than BALB mothers. BALB female offspring reared by CBA mothers showed more body licking than those reared by BALB mothers, whereas fostering did not affect the maternal behavior of CBA female offspring. In Experiment 2, we examined the maternal behavior of females of F1 hybrids derived from reciprocal crosses between the two strains to confirm the maternal effect demonstrated in Experiment 1. Female F1 hybrids from CBA mothers showed more arched‐back nursing, body licking, and nest building than those from BALB mothers. These results suggested that maternal care affect the development of maternal behavior in inbred mice, though the contributions of genetic and prenatal factors cannot be ignored. © 2009 Wiley Periodicals, Inc. Dev. Psychobiol 51: 345–357, 2009.
Early independent walking: A longitudinal study of load perturbation effects
Authors: Vereijken Beatrix , Pedersen Arve Vorland , Størksen Jan Harry 
Published: April 2009

AbstractThis study investigated infants' ability to adapt to experimentally induced changes in their body dimensions at walk onset, and how this ability is affected by increased walking experience. Fifteen infants were studied over their first 6 months of independent walking with a load perturbation design. They traversed a walkway with loads symmetrically placed around the shoulders, waist, or ankles, and without loading. At walk onset, infants fell more with shoulder and ankle loads than with waist or no loads. Shoulder loads further resulted in higher walking speed and longer steps, while waist loads resulted in increased walking speed and larger foot rotation. Ankle loads disrupted walking proficiency the most, as indicated by lower walking speed, shorter steps, larger foot rotation, and smaller step‐to‐step angle. Step width was not differentially affected by the conditions. With increased experience, walking proficiency increased across all conditions, but ankle loads lagged behind the other conditions. Loading effects are discussed with respect to walking experience and position of the loads on the body. © 2009 Wiley Periodicals, Inc. Dev Psychobiol 51: 374–383, 2009.
N‐cadherin prodomain cleavage regulates synapse formation in vivo
Authors: Latefi Nazlie S. , Pedraza Liliana , Schohl Anne , Li Ziwei , Ruthazer Edward S. 
Published: April 2009

AbstractCadherins are initially synthesized bearing a prodomain that is thought to limit adhesion during early stages of biosynthesis. Functional cadherins lack this prodomain, raising the intriguing possibility that cells may utilize prodomain cleavage as a means to temporally or spatially regulate adhesion after delivery of cadherin to the cell surface. In support of this idea, immunostaining for the prodomain of zebrafish N‐cadherin revealed enriched labeling at neuronal surfaces at the soma and along axonal processes. To determine whether post‐translational cleavage of the prodomain affects synapse formation, we imaged Rohon‐Beard cells in zebrafish embryos expressing GFP‐tagged wild‐type N‐cadherin (NCAD‐GFP) or a GFP‐tagged N‐cadherin mutant expressing an uncleavable prodomain (PRON‐GFP) rendering it nonadhesive. NCAD‐GFP accumulated at synaptic microdomains in a developmentally regulated manner, and its overexpression transiently accelerated synapse formation. PRON‐GFP was much more diffusely distributed along the axon and its overexpression delayed synapse formation. Our results support the notion that N‐cadherin serves to stabilize pre‐ to postsynaptic contacts early in synapse development and suggests that regulated cleavage of the N‐cadherin prodomain may be a mechanism by which the kinetics of synaptogenesis are regulated. © 2009 Wiley Periodicals, Inc. Develop Neurobiol 2009