bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spring and Summer Midwestern Severe Weather Reports in Supercells Compared to Other Morphologies
Authors: Duda Jeffrey D. , Gallus William A. 
Published: October 2009

Abstract
This study compares severe weather reports associated with the nine convective system morphologies used in a recent study by Gallus et al. to an additional morphology, supercell storms. As in that previous study, all convective systems occurring in a 10-state region covering parts of the Midwestern United States and central plains were classified according to their dominant morphology, and severe weather reports associated with each morphology were then analyzed. Unlike the previous study, which examined systems from 2002, the time period over which the climatology was performed was shifted to 2007 to allow access to radar algorithm information needed to classify a storm as a supercell.
Archived radar imagery was used to classify systems as nonlinear convective events, isolated cells, clusters of cells, broken lines of cells, squall lines with no stratiform precipitation, trailing stratiform precipitation, parallel stratiform precipitation, and leading stratiform precipitation, and bow echoes. In addition, the three cellular classifications were subdivided to allow an analysis of severe weather reports for events in which supercells were present and those in which they were not.
As in the earlier study, all morphologies were found to pose some risk of severe weather, and differences in the two datasets were generally small. The 2007 climatology confirmed the theory that supercellular systems produce severe weather more frequently than other morphologies, and also produce more intense severe weather. Supercell systems were especially prolific producers of tornadoes and hail relative to all other morphologies, but also produced severe wind and flooding much more often than nonsupercell cellular morphologies. These results suggest that it is important to differentiate between cellular morphologies containing rotation and those that do not when associating severe weather reports with convective morphology.
Comparison between Single- and Double-Bundle Anterior Cruciate Ligament Reconstruction
Authors: Aglietti Paolo , Giron Francesco , Losco Michele , Cuomo Pierluigi , Ciardullo Antonio , Mondanelli Nicola 
Published: October 2009

Background Double-bundle ACL reconstruction popularity is increasing with the aim to reproduce native ACL anatomy and improve ACL reconstruction outcome. However, to date, only a few randomized clinical studies have been published. Purpose The aim of this study was to prospectively compare the clinical results of single- and double-bundle ACL reconstruction. Study Design Randomized controlled clinical trial; Level of evidence, 1. Methods Seventy patients with a chronic unilateral ACL rupture who underwent arthroscopically assisted ACL reconstruction using a hamstring graft were randomized to receive a single- (SB) or double-bundle (DB) reconstruction. Both groups were comparable with regard to preoperative data. A double-incision surgical technique was adopted in both groups. The graft was fixed by looping the hamstring tendons around a bony (DB) or a metallic (SB) bridge on the tibial side and with interference screws reinforced with a staple on the femur. The same rehabilitation protocol was adopted. Outcome assessment was performed by a blinded, independent observer using the visual analog scale (VAS) score, the new International Knee Documentation Committee (IKDC) form, the Knee Injury and Osteoarthritis Outcome Score (KOOS), and KT-1000 arthrometer evaluation. Results All the patients reached a minimum follow-up of 2 years. No differences between the 2 groups were observed in terms of KOOS and IKDC subjective score. A statistically significant difference in favor of the DB group was found with the VAS (P < .03). The objective IKDC final scores showed statistically significantly more “normal knees” in the DB group than in the SB group (P = .03). There was 1 stability failure in the DB group and 3 in the SB group. The KT-1000 arthrometer data showed a statistically significant decrease in the average anterior tibial translation in the DB group (1.2 mm DB vs 2.1 mm SB; P < .03). The incidence of a residual pivot-shift glide was 14% in DB and 26% in SB (P = .08). Conclusion In the 2-year minimum follow-up, DB ACL reconstructions showed better VAS, anterior knee laxity, and final objective IKDC scores than SB. However, longer follow-up and accurate instrumented in vivo rotational stability assessment are needed.
An Examination of the Psychometric Properties of the Pediatric Symptom Checklist With Children Enrolled in Medicaid
Authors: Boothroyd Roger Alan , Armstrong Mary 
Published: October 2009

The federal Early and Periodic Screening, Diagnosis, and Treatment (EPSDT) program requires mental health screening of Medicaid-eligible children as part of primary care medical assessments. However, decisions related to selection of a screening tool remain with the states. States need access to brief, cost effective, easily administered screening tools to comply with these regulations. This paper examines the psychometric properties of the Pediatric Symptom Checklist (PSC) reported on 6,590 children ages 6-22 enrolled in Florida’s Medicaid program across seven areas of the state, whose caregivers participated in a mail survey at least once between 1998 and 2007. Results suggest the PSC has both good internal consistency and stability over time across children with varying health and mental health conditions. The PSC demonstrated excellent discriminant validity regarding its ability to differentiate among children with varying levels of disabilities. Evidence of the PSCs construct validity was found based on its significant associations with other measures in predicted directions. At the recommended cut-off score of 28, the PSC exhibited good sensitivity, specificity, positive predictive value, and negative predictive value. Collectively, these findings support the use of the PSC as an appropriate measure for screening the psychosocial needs of children enrolled in Medicaid.
Chronic myeloid leukemia: a prospective comparison of interphase fluorescence in situ hybridization and chromosome banding analysis for the definition of complete cytogenetic response: a study of the GIMEMA CML WP
Authors: Testoni Nicoletta , Marzocchi Giulia , Luatti Simona , Amabile Marilina , Baldazzi Carmen , Stacchini Monica , Nanni Mauro , Rege-Cambrin Giovanna , Giugliano Emilia , Giussani Ursula , Abruzzese Elisabetta , Kerim Simonetta , Grimoldi Maria Grazia , Gozzetti Alessandro , Crescenzi Barbara , Carcassi Carlo , Bernasconi Paolo , Cuneo Antonio , Albano Francesco , Fugazza Giuseppina , Zaccaria Alfonso , Martinelli Giovanni , Pane Fabrizio , Rosti Gianantonio , Baccarani Michele 
Published: October 2009

Abstract
In chronic myeloid leukemia, different methods are available to monitor the response to therapy: chromosome banding analysis (CBA), interphase fluorescence in situ hybridization (I-FISH), and real-time quantitative polymerase chain reaction (RT-Q-PCR). The GIMEMA CML WP (Gruppo Italiano Malattie Ematologiche Adulto Chronic Myeloid Leukemia Working Party) has performed a prospective study to compare CBA and I-FISH for the definition of complete cytogenetic response (CCgR). Samples (n = 664) were evaluated simultaneously by CBA and I-FISH. Of 537 cases in CCgR, the number of positive nuclei by I-FISH was less than 1% in 444 cases (82.7%). Of 451 cases with less than 1% positive nuclei by I-FISH, 444 (98.4%) were classified as CCgR by CBA. The major molecular response rate was significantly greater in cases with I-FISH less than 1% than in those with I-FISH 1% to 5% (66.8% vs 51.6%, P < .001) and in cases with CCgR and I-FISH less than 1% than in cases with CCgR and I-FISH 1% to 5% (66.1% vs 49.4%, P = .004). I-FISH is more sensitive than CBA and can be used to monitor CCgR. With appropriate probes, the cutoff value of I-FISH may be established at 1%. These trials are registered at http://www.clinicaltrials.gov as NCT00514488 and NCT00510926.
The effect of titanium dioxide nanoparticles on pulmonary surfactant function and ultrastructure
Authors: Schleh Carsten , Mühlfeld Christian , Pulskamp Karin , Schmiedl Andreas , Nassimi Matthias , Lauenstein Hans D , Braun Armin , Krug Norbert , Erpenbeck Veit J , Hohlfeld Jens M 
Published: October 2009

Abstract

Background
Pulmonary surfactant reduces surface tension and is present at the air-liquid interface in the alveoli where inhaled nanoparticles preferentially deposit. We investigated the effect of titanium dioxide (TiO2) nanosized particles (NSP) and microsized particles (MSP) on biophysical surfactant function after direct particle contact and after surface area cycling in vitro. In addition, TiO2 effects on surfactant ultrastructure were visualized.

Methods
A natural porcine surfactant preparation was incubated with increasing concentrations (50-500 μg/ml) of TiO2 NSP or MSP, respectively. Biophysical surfactant function was measured in a pulsating bubble surfactometer before and after surface area cycling. Furthermore, surfactant ultrastructure was evaluated with a transmission electron microscope.

Results
TiO2 NSP, but not MSP, induced a surfactant dysfunction. For TiO2 NSP, adsorption surface tension (γads) increased in a dose-dependent manner from 28.2 ± 2.3 mN/m to 33.2 ± 2.3 mN/m (p < 0.01), and surface tension at minimum bubble size (γmin) slightly increased from 4.8 ± 0.5 mN/m up to 8.4 ± 1.3 mN/m (p < 0.01) at high TiO2 NSP concentrations. Presence of NSP during surface area cycling caused large and significant increases in both γads (63.6 ± 0.4 mN/m) and γmin (21.1 ± 0.4 mN/m). Interestingly, TiO2 NSP induced aberrations in the surfactant ultrastructure. Lamellar body like structures were deformed and decreased in size. In addition, unilamellar vesicles were formed. Particle aggregates were found between single lamellae.

Conclusion
TiO2 nanosized particles can alter the structure and function of pulmonary surfactant. Particle size and surface area respectively play a critical role for the biophysical surfactant response in the lung.
BioGateway: a semantic systems biology tool for the life sciences
Authors: Antezana Erick , Blondé Ward , Egaña Mikel , Rutherford Alistair , Stevens Robert , De Baets Bernard , Mironov Vladimir , Kuiper Martin 
Published: October 2009

Abstract

Background
Life scientists need help in coping with the plethora of fast growing and scattered knowledge resources. Ideally, this knowledge should be integrated in a form that allows them to pose complex questions that address the properties of biological systems, independently from the origin of the knowledge. Semantic Web technologies prove to be well suited for knowledge integration, knowledge production (hypothesis formulation), knowledge querying and knowledge maintenance.

Results
We implemented a semantically integrated resource named BioGateway, comprising the entire set of the OBO foundry candidate ontologies, the GO annotation files, the SWISS-PROT protein set, the NCBI taxonomy and several in-house ontologies. BioGateway provides a single entry point to query these resources through SPARQL. It constitutes a key component for a Semantic Systems Biology approach to generate new hypotheses concerning systems properties. In the course of developing BioGateway, we faced challenges that are common to other projects that involve large datasets in diverse representations. We present a detailed analysis of the obstacles that had to be overcome in creating BioGateway. We demonstrate the potential of a comprehensive application of Semantic Web technologies to global biomedical data.

Conclusion
The time is ripe for launching a community effort aimed at a wider acceptance and application of Semantic Web technologies in the life sciences. We call for the creation of a forum that strives to implement a truly semantic life science foundation for Semantic Systems Biology.
Access to the system and supplementary information (such as a listing of the data sources in RDF, and sample queries) can be found at http://www.semantic-systems-biology.org/biogateway.
Combined phylogeny and neighborhood analysis of the evolution of the ABC transporters conferring multiple drug resistance in hemiascomycete yeasts
Authors: Seret Marie-Line , Diffels Julie F , Goffeau André , Baret Philippe V 
Published: October 2009

Abstract

Background
Pleiotropic Drug Resistant transporters (PDR) are members of the ATP-Binding Cassette (ABC) subfamily which export antifungals and other xenobiotics in fungi and plants. This subfamily of transmembrane transporters has nine known members in Saccharomyces cerevisiae.
We have analyzed the complex evolution of the pleiotropic drug resistance proteins (Pdrp) subfamily where gene duplications and deletions occur independently in individual genomes.
This study was carried out on 62 Pdrp from nine hemiascomycetous species, seven of which span 6 of the 14 clades of the Saccharomyces complex while the two others species, Debaryomyces hansenii and Yarrowia lipolytica, are further apart from an evolutive point of view.

Results
Combined phylogenetic and neighborhood analyses enabled us to identify five Pdrp clusters in the Saccharomyces complex. Three of them comprise orthologs of the Pdrp sensu stricto, Pdr5p, Pdr10p, Pdr12p, Pdr15p, Snq2p and YNR070wp. The evolutive pathway of the orthologs of Snq2 and YNR070w is particularly complex due to a tandem gene array in Eremothecium gossypii, Kluyveromyces lactis and Saccharomyces (Lachancea) kluyveri. This pathway and different cases of duplications and deletions were clarified by using a neighborhood analysis based on synteny.
For the two distant species, Yarrowia lipolytica and Debaryomyces hansenii, no neighborhood evidence is available for these clusters and many homologs of Pdr5 and Pdr15 are phylogenetically assigned to species-based clusters.
Two other clusters comprise the orthologs of the sensu lato Pdrp, Aus1p/Pdr11p and YOL075cp respectively. The evolutionary pathway of these clusters is simpler. Nevertheless, orthologs of these genes are missing in some species.

Conclusion
Numerous duplications were traced among the Hemiascomycetous Pdrp studied. The role of the Whole Genome Duplication (WGD) is sorted out and our analyses confirm the common ancestrality of Pdr5p and Pdr15p. A tandem gene array is observed in Eremothecium gossypii. One of the copies is the ortholog of Snq2 while the other one is lost in the post-WGD species.
The neighborhood analysis provides an efficient method to trace the history of genes and disentangle the orthology and paralogy relationships.
An evaluation of the appropriateness of advice and healthcare contacts made following calls to NHS Direct Wales
Authors: Snooks Helen , Peconi Julie , Munro James , Cheung Wai-Yee , Rance Jaynie , Williams Anne 
Published: October 2009

Abstract

Background
An evaluation of NHS Direct Wales (NHSDW), a national telephone-based healthcare advice and information service, was undertaken. A key objective was to describe the actions of callers and assess the appropriateness of advice and healthcare contacts made following calls, results of which are reported here.

Methods
Postal questionnaires were sent to consecutive callers to NHSDW in May 2002 and February 2004 to determine 1) callers' actions following calls and 2) their views about the appropriateness of: advice given; and when to seek further care. An independent clinical panel agreed and applied a set of rules about healthcare sites where examinations, investigations, treatments and referrals could be obtained. The rules were then applied to the subsequent contacts to healthcare services reported by respondents and actions were classified in terms of whether they had been necessary and sufficient for the care received.

Results
Response rates were similar in each survey: 1033/1897 (54.5%); 606/1204 (50.3%), with 75% reporting contacting NHSDW. In both surveys, nearly half of all callers reported making no further healthcare contact after their call to NHSDW. The most frequent subsequent contacts made were with GPs.
More than four fifths of callers rated the advice given - concerning any further care needed and when to seek it - as appropriate (further care needed: survey 1: 673/729, 82.3%; survey 2: 389/421, 92.4%; when to seek further care - survey 1: 462/555, 83.2%; survey 2: n = 295/346, 85.3%). A similar proportion of cases was also rated through the rule set and backed up by the clinical panel as having taken necessary and sufficient actions following their calls to NHSDW (survey 1: 624/729, 80.6%; survey 2: 362/421, 84.4%), with more unnecessary than insufficient actions identified at each survey (survey 1: unnecessary 132/729, 17.1% versus insufficient 11/729, 1.4%; survey 2: unnecessary 47/421, 11.0% versus insufficient 14/421, 3.3%).

Conclusion
Based on NHSDW caller surveys responses and applying a transparent rule set to caller actions a large majority of subsequent actions were assessed as appropriate, with insufficient contacts particularly infrequent. The challenge for NHSDW is to reduce the number of unnecessary contacts made following calls to the service, whilst maintaining safety.
Positive anti-citrullinated protein antibody status and small joint arthritis are consistent predictors of chronic disease in patients with very early arthritis: results from the NOR-VEAC cohort
Authors: Mjaavatten Maria D , Uhlig Till , Haugen Anne J , Nygaard Halvor , Sidenvall Göran , Helgetveit Knut , Kvien Tore K 
Published: October 2009

Abstract
Introduction
The current 1987 American College of Rheumatology (ACR) classification criteria for rheumatoid arthritis (RA) have proven less useful in early arthritis. The objective of this study was to identify and compare predictors of three relevant outcomes of chronic arthritis in a cohort of very early arthritis patients.

Methods
The Norwegian Very Early Arthritis Cohort (NOR-VEAC) includes adult patients with at least one swollen joint of ≤16 weeks' duration. Patients are followed for 2 years with comprehensive clinical and laboratory examinations. Logistic regression analyses were performed to determine independent predictors of three outcomes: persistent synovitis, prescription of disease-modifying anti-rheumatic drugs (DMARDs), and established clinical RA diagnosis within one year.

Results
Of 384 patients eligible for one year follow-up (56.3% females, mean (SD) age 45.8 (14.7) years, median (IQR) duration of arthritis 31 (10-62) days), 14.4% were anti-CCP2 positive, and 11.2% were IgM RF positive. 98 patients (25.5%) had persistent synovitis, 106 (27.6%) had received DMARD treatment during follow-up, while 68 (17.7%) were diagnosed with RA. Consistent independent predictors across all three outcomes were positive anti-citrullinated protein antibody (ACPA) status (odds ratio (OR) 3.2, 5.6 and 19.3), respectively, and small joint arthritis (proximal interphalangeal joint (PIP), metacarpo-phalangeal joint (MCP), and/or metatarso-phalangeal joint (MTP) joint swelling) (OR 1.9, 3.5, and 3.5, respectively).

Conclusions
Positive ACPA status and small joint arthritis were consistent predictors of three relevant outcomes of chronic arthritis in very early arthritis patients. This consistency supports DMARD prescription as a valid surrogate endpoint for chronic arthritis. Importantly, this surrogate is used in ongoing efforts to develop new diagnostic criteria for early RA.
Syntactic probabilities affect pronunciation variation in spontaneous speech
Authors: Tily Harry , Gahl Susanne , Arnon Inbal , Snider Neal , Kothari Anubha , Bresnan Joan 
Published: October 2009

AbstractSpeakers frequently have a choice among multiple ways of expressing one and the same thought. When choosing between syntactic constructions for expressing a given meaning, speakers are sensitive to probabilistic tendencies for syntactic, semantic or contextual properties of an utterance to favor one construction or another. Taken together, such tendencies may align to make one construction overwhelmingly more probable, marginally more probable, or no more probable than another. Here, we present evidence that acoustic features of spontaneous speech reflect these probabilities: when speakers choose a less probable construction, they are more likely to be disfluent, and their fluent words are likely to have a relatively longer duration. Conversely, words in more probable constructions are shorter and spoken more fluently. Our findings suggest that the differing probabilities of a syntactic construction in context are not epiphenomenal, but reflect a part of a speakers' knowledge of their language.
Correlation versus prediction in children's word learning: Cross-linguistic evidence and simulations
Authors: Colunga Eliana , Smith Linda B. , Gasser Michael 
Published: October 2009

AbstractThe ontological distinction between discrete individuated objects and continuous substances, and the way this distinction is expressed in different languages has been a fertile area for examining the relation between language and thought. In this paper we combine simulations and a cross-linguistic word learning task as a way to gain insight into the nature of the learning mechanisms involved in word learning. First, we look at the effect of the different correlational structures on novel generalizations with two kinds of learning tasks implemented in neural networks—prediction and correlation. Second, we look at English- and Spanish-speaking 2-3-year-olds' novel noun generalizations, and find that count/mass syntax has a stronger effect on Spanish- than on English-speaking children's novel noun generalizations, consistent with the predicting networks. The results suggest that it is not just the correlational structure of different linguistic cues that will determine how they are learned, but the specific learning mechanism and task in which they are involved.
Toward a theory of semantic representation
Authors: Vigliocco Gabriella , Meteyard Lotte , Andrews Mark , Kousta Stavroula 
Published: October 2009

AbstractWe present an account of semantic representation that focuses on distinct types of information from which word meanings can be learned. In particular, we argue that there are at least two major types of information from which we learn word meanings. The first is what we call experiential information. This is data derived both from our sensory-motor interactions with the outside world, as well as from our experience of own inner states, particularly our emotions. The second type of information is language-based. In particular, it is derived from the general linguistic context in which words appear. The paper spells out this proposal, summarizes research supporting this view and presents new predictions emerging from this framework.