bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Interplay of Age Stratification and HPV Testing on the Predictive Value of ASC-US Cytology
Authors: Stoler Mark H. , Wright Thomas C. , Sharma Abha , Zhang Guili , Apple Raymond , Wright Teresa L. , Behrens Catherine M. ,   the ATHENA (Addressing THE Need for Advanced HPV Diagnostics) Study Group
Published: January 2012

Abstract
We have previously shown that human papillomavirus (HPV) genotyping, using the cobas HPV Test (Roche Molecular Systems, Pleasanton, CA), can be used to identify women with atypical squamous cells of undetermined significance (ASC-US) at the highest risk for cervical intraepithelial neoplasia (CIN) grade 2 or worse. We investigated the impact of age stratification on the risk of CIN 2 or worse in women with ASC-US and the performance of HPV genotyping in different age strata.
The sensitivity of the cobas HPV Test was 93.3% in the 21- to 29-year-old age group and 67.7% in the 40 years or older group, most likely owing to pathologic misclassification of CIN 2 or worse in older women. The prevalence of CIN 2 or worse in younger women was nearly 4-fold that detected in older women and was predominantly HPV-16–related.
Age-specific evaluation of ASC-US cytology in conjunction with HPV genotype status enables more effective risk assessment and could be used in clinical management.
CD117 Expression Is a Sensitive but Nonspecific Predictor of FLT3 Mutation in T Acute Lymphoblastic Leukemia and T/Myeloid Acute Leukemia
Authors: Hoehn Daniela , Medeiros L. Jeffrey , Chen Su S. , Tian Tian , Jorgensen Jeffrey L. , Ahmed Yasin , Lin Pei 
Published: January 2012

Abstract
Others have suggested that CD117, or an immunophenotypic profile including CD117, can serve as surrogate for FLT3 mutation in T acute lymphoblastic leukemia (ALL), thereby guiding targeted therapy. We report the results of flow cytometry immunophenotypic analysis in 42 cases of T-ALL and T/myeloid acute leukemia also assessed for FLT3 mutation. CD117 was expressed in 21 (50%), and FLT3 was mutated in 8 cases (19%; 1 T-ALL and 7 T/myeloid). FLT3-mutated cases were terminal deoxynucleotidyl transferase (TdT)+/CD2+ (7/8), cytoplasmic CD3+/CD5+ (5/8), CD7+/CD13+/CD15+ (4/6), CD33+ (4/8), CD34+, and CD117+ (bright). Cytochemistry showed myeloperoxidase-positive cells in all T/myeloid acute leukemias (3%–50%). We conclude that FLT3 mutation is rare in T-ALL, and its presence supports T/myeloid lineage. CD117 expression alone is sensitive but not specific for FLT3 mutation. The immunophenotypic profile of TdT, CD7, CD13, CD34, and CD117 (bright) is helpful for predicting FLT3 mutation, with a sensitivity of 100% and specificity of 94%.
Engineering Properties of Cement–Treated Granular Soil for Geotechnical Application
Authors: Dong P. H. , Hayano K. , Morikawa Y. , Takahashi H. 
Published: January 2012

Abstract
This study introduces a new method to produce a granular material to encourage use of dredged materials for construction applications. Cement Treated Granular Soil (CTGS) was produced from dredged marine clay mixed with proper amounts of cement and polymer. This study focuses on lean mixture design to reduce the production cost. The applicability of CTGS as a geomaterial was verified based on engineering properties (i.e., compaction characteristics, California Bearing Ratio, compressibility, strength and deformation characteristics) obtained from laboratory tests. The principle of treatment and physical properties of CTGS are also discussed. It was found that CTGS is lightweight, has high porosity, and possesses similar characteristics to conventional granular materials. The densification is not sensitive to water content, and the strength and stiffness parameters obtained from the tests indicate that CTGS shows high potential for applications such as reclamation, subgrade, or backfill material.
Infinit-dimensionaler Reglerentwurf für Euler-Bernoulli Balken mit Macro-Fibre Composite Aktoren
Authors: Henikl Johannes , Schröck Johannes , Meurer Thomas , Kugi Andreas 
Published: January 2012

Zusammenfassung
Dieser Beitrag beschäftigt sich mit der Regelung eines einseitig eingespannten Euler-Bernoulli Balkens mit piezoelektrischen Aktoren, die in Form von Macro-Fibre Composite Patches realisiert sind. Auf Basis des verteilt-parametrischen mathematischen Modells wird eine nicht-kollokierte dynamische Ausgangsregelung entworfen, die die asymptotische Stabilität des geschlossenen Regelkreises gewährleistet. Neben der mathematischen Analyse werden die entwickelten Methoden an einem Versuchsstand experimentell validiert. Die Messergebnisse zeigen die Machbarkeit des vorgestellten Ansatzes.
What Is the Utility of Distal Forearm DXA in Primary Hyperparathyroidism?
Authors: Wood Kelly , Dhital Subarna , Chen Herbert , Sippel Rebecca S. 
Published: January 2012

Abstract

Background.
Primary hyperparathyroidism (PHPT) leads to increased bone turnover, low bone mineral density, and increased fracture risk. These effects are, however, preferentially seen in the distal forearm, which is rich in cortical bone. This study aimed to determine how frequently the distal forearm T score was the worst T score and if this T score alone led to higher rate of diagnosis of osteopenia or osteoporosis.

Materials and Methods.
We retrospectively reviewed a prospective database of 300 patients undergoing parathyroidectomy at our institution between November 2000 and January 2009. The bone mineral density of the lumbar spine, total proximal femurs, and distal third of the nondominant radius was measured by dual x-ray absorptiometry. Data on bone density are reported as T scores.

Results.
The mean T scores were −1.30 ± 0.2 in the distal forearm, −1.0 ± 0.1 in the total proximal femurs, and −0.9 ± 0.1 in the spine. The distal forearm T score was the worst bone mineral density T score in 39% of patients. This T score alone led to an upstaging in diagnosis to osteopenia or osteoporosis in 9.4% of patients.

Conclusion.
In patients with PHPT, the worst T score is commonly found in the distal forearm. This T score can identify additional patients with a diagnosis of osteopenia or osteoporosis. Distal forearm bone mineral density should, therefore, be assessed in all patients who have a diagnosis of PHPT.
Prevalence of Perceived Stress and Mental Health Indicators Among Reserve-Component and Active-Duty Military Personnel
Authors: Lane Marian E. , Hourani Laurel L. , Bray Robert M. , Williams Jason 
Published: January 2012

Objectives. We examined stress levels and other indicators of mental health in reservists and active-duty military personnel by deployment status. Methods. We used data from the Department of Defense Health-Related Behaviors surveys, which collect comprehensive, population-based data for reserve and active-duty forces. Data were collected from 18 342 reservists and 16 146 active-duty personnel. Results. Overall, with adjustment for sociodemographic and service differences, reservists reported similar or less work and family stress, depression, and anxiety symptoms than did active-duty personnel. However, reservists who had been deployed reported higher rates of suicidal ideation and attempts than did active-duty personnel who had been deployed and higher rates of post-traumatic stress disorder symptomatology than did any active-duty personnel and reservists who had not been deployed. The highest rates of suicidal ideation and attempts were among reservists who had served in theaters other than Iraq and Afghanistan. Conclusions. Our results suggest that deployment has a greater impact on reservists than on active-duty members, thus highlighting the urgent need for services addressing reservists’ unique postdeployment mental health issues. Also, deployment to any theater, not only Iraq or Afghanistan, represents unique threats to all service members’ mental well-being.
Correlates of Suicidality: Investigation of a Representative Sample of Manitoba First Nations Adolescents
Authors: Mota Natalie , Elias Brenda , Tefft Bruce , Medved Maria , Munro Garry , Sareen Jitender 
Published: January 2012

Objectives. We examined individual, friend or family, and community or tribe correlates of suicidality in a representative on-reserve sample of First Nations adolescents.Methods. Data came from the 2002–2003 Manitoba First Nations Regional Longitudinal Health Survey of Youth. Interviews were conducted with adolescents aged 12 to 17 years (n = 1125) from 23 First Nations communities in Manitoba. We used bivariate logistic regression analyses to examine the relationships between a range of factors and lifetime suicidality. We conducted sex-by-correlate interactions for each significant correlate at the bivariate level. A multivariate logistic regression analysis identified those correlates most strongly related to suicidality.Results. We found several variables to be associated with an increased likelihood of suicidality in the multivariate model, including being female, depressed mood, abuse or fear of abuse, a hospital stay, and substance use (adjusted odds ratio range = 2.43–11.73). Perceived community caring was protective against suicidality (adjusted odds ratio = 0.93; 95% confidence interval = 0.88, 0.97) in the same model.Conclusions. Results of this study may be important in informing First Nations and government policy related to the implementation of suicide prevention strategies in First Nations communities.
Enumeration and Composition of the Public Health Workforce: Challenges and Strategies
Authors: Sumaya Ciro V. 
Published: January 2012

The field of public health needs a comprehensive classification data system that provides a better assessment of the size and composition of its workforce. Such a data system is necessary for understanding the capacity, trend projections, and policy development critical to the future workforce. Previous enumeration and composition studies on the public health workforce have been helpful, but the methodology used needs further improvements in standardization, specificity, data storage, and data availability. Resolving this issue should follow a consensus-based course of action that includes public and private stakeholders at the national, state, and local level. This prime issue should be addressed now, particularly in the current environment of comprehensive health care reform.
Sexual Timetables for Oral-Genital, Vaginal, and Anal Intercourse: Sociodemographic Comparisons in a Nationally Representative Sample of Adolescents
Authors: Halpern Carolyn Tucker , Haydon Abigail A. 
Published: January 2012

Objectives. We documented the prevalence and relative timing of oral-genital, vaginal, and anal intercourse during adolescence and examined whether these timetables varied by sociodemographic factors.Methods. We used data from almost 14 000 Wave IV respondents to the National Longitudinal Study of Adolescent Health to generate prevalence estimates for adolescents who reached age 18 years by 2001 and logistic and ordinary least squares regression to examine sociodemographic correlates of sexual patterns.Results. One in 5 adolescents did not engage in any of these sexual behaviors by age 18 years. More than two thirds reported vaginal or oral-genital sexual activity, but only about half experienced both. One in 10 reported anal intercourse experience. A third initiated 2 or more behaviors within a 1-year period. In longer timetables, vaginal intercourse was more often initiated first. Most sociodemographic characteristics examined were uniquely associated with prevalence and sexual timing.Conclusions. Diversity in patterns of sexual initiation occurring in the 1990s underscores the ongoing need for comprehensive and nuanced examinations of adolescent sexual trajectories and their implications for sexual health in more recent cohorts.
Public Health Surveillance and Meaningful Use Regulations: A Crisis of Opportunity
Authors: Lenert Leslie , Sundwall David N. 
Published: January 2012

The Health Information Technology for Economic and Clinical Health Act is intended to enhance reimbursement of health care providers for meaningful use of electronic health records systems. This presents both opportunities and challenges for public health departments. To earn incentive payments, clinical providers must exchange specified types of data with the public health system, such as immunization and syndromic surveillance data and notifiable disease reporting. However, a crisis looms because public health’s information technology systems largely lack the capabilities to accept the types of data proposed for exchange. Cloud computing may be a solution for public health information systems. Through shared computing resources, public health departments could reap the benefits of electronic reporting within federal funding constraints.
Avondale Estates: A Case Study in Governmental Accounting and Auditing—A Historical Approach
Authors: Ariail Donald L. , Durden Joe , Leathart Marilynn , Chapman-Vasill Lynette 
Published: January 2012

ABSTRACT
The 82 years of accounting evolution that separate the audits of 1928 and 2009 under different accounting and auditing standards are examined through a cross-disciplined case study that compares the historical 1928 and the contemporary 2009 financial statements and the accompanying audit reports of Avondale Estates, Georgia. The 1928 and 2009 reports and financial statements of this municipality, along with the municipality's current budget information accessible over the Internet, can be used in a number of ways to enhance the instruction of governmental accounting at the undergraduate, graduate, and doctoral levels. In addition to aiding in the teaching of current governmental accounting standards, the case also can be used to give the student a historical perspective on governmental accounting and the accounting profession. By comparing the accounting and reporting standards used in 1928 and 2009, the student will gain an understanding of the evolution of accounting thought. Moreover, the auditors' reports for the two periods illustrate the historical and continuing public service role of the CPA profession as detailed in ET Section 53 of the AICPA Professional Standards (AICPA 2010). Thus, this case study gives the accounting instructor a useful vehicle for teaching accounting history and thought.
Cancer screening in the United States, 2012
Authors: Smith Robert A. , Cokkinides Vilma , Brawley Otis W. 
Published: January 2012

AbstractEach year the American Cancer Society (ACS) publishes a summary of its recommendations for early cancer detection, a report on data and trends in cancer screening rates, and select issues related to cancer screening. In this issue of the journal, current ACS cancer screening guidelines are summarized, as are the latest data on the use of cancer screening from the National Health Interview Survey. CA Cancer J Clin 2012. © 2012 American Cancer Society.
De l’expérimentation multimédia à l’analyse
Authors: Cazade Alain 
Published: January 2012

La recherche sur les « parcours apprenants » à l’aide d’outils électroniques est encore jeune. Pourtant, avec les développements actuels de l’enseignement des langues appuyé sur le multimédia, avec l’évolution des outils et des matériels dans ce secteur, de plus en plus accessibles et/ou adaptables aux besoins tant sur le plan de la recherche que sur celui de la pédagogie, elle ne peut que se révéler très prometteuse à maints égards. Malgré ce que d’aucuns seraient tentés de croire, la difficulté la plus sérieuse n’est pas liée à la maîtrise de ces outils, mais bien plutôt au choix des données que l’on souhaite analyser, à la mise au point de protocoles d’expérimentation productifs et fiables et donc à la réflexion sur ce que peut être un parcours apprenant.
La maille et le nœud : apprendre en réseau
Authors: Rézeau Joseph 
Published: January 2012

Le thème proposé à la réflexion des congressistes du GERAS en mars 1999, « Les réseaux », a été pour nous l’occasion de parcourir divers aspects de la métaphore réticulaire dans la perspective de notre travail de didacticien des langues. Nous évoquons le réseau comme filet permettant de retenir l’apprenant puis permettant à celui-ci de retenir le savoir ; puis le réseau comme support de l’information et du savoir, avec en particulier les réseaux sémantiques.
Homing and Adhesion Patterns Determine the Cellular Composition of the Bone Marrow Plasma Cell Niche
Authors: Belnoue Elodie , Tougne Chantal , Rochat Anne-Françoise , Lambert Paul-Henri , Pinschewer Daniel D. , Siegrist Claire-Anne 
Published: January 2012

Abstract
According to commonly held concepts, plasma cell (PC) longevity in bone marrow (BM) depends upon their access to survival niches. These are thought to exist in nursery cell types, which support PCs by secreting PC survival factors. To better define PC survival niches and their functioning, we adoptively transferred traceable Blimp-1-GFP PCs into recipient mice lacking a proliferation-inducing ligand (APRIL), IL-6, or macrophage migration inhibitory factor. Transferred BMPCs were preferentially associated with Ly-6Chigh monocytes (normalized colocalization index: 9.84), eosinophils (4.29), and megakaryocytes (2.12). Although APRIL was essential for BMPC survival, PC recruitment into the proximity of nursery cells was unimpaired in APRIL-deficient mice, questioning the concept that the same factors account for attraction/retention of PCs as for their local survival. Rather, the order of colocalization with BMPCs (monocytes &gt; eosinophils &gt; megakaryocytes) reflected these cells’ relative expression of CXCR4, VLA-4, and LFA-1, the homing and adhesion molecules that direct/retain PCs in the BM. This suggests a scenario wherein the cellular composition of the BMPC niche is defined by a common pattern of attraction/retention on CXCL12-abundant reticular docking cells. Thereby, PCs are directed to associate in a functional BM niche with hematopoietic CXCR4+VLA-4+LFA-1+ nursery cells, which provide PC survival factors.
The Influence of Hand Use on Dressing Outcome in Cognitively Impaired Stroke Survivors
Authors: Fletcher-Smith Joanna , Walker Marion F , Drummond Avril 
Published: January 2012

Introduction: The daily task of dressing oneself requires multiple complex skills, which are often taken for granted by those free from ill-health or disability. Independence in dressing allows an individual to maintain a sense of dignity and choice over his or her appearance. Occupational therapy aims to restore independent functional performance in daily activities. Dressing independence requires both physical and cognitive skills. For survivors of stroke, impairment of such skills can pose great difficulty to their dressing performance. Method: The aim of this study was to examine the effect of arm paresis and cognitive impairment on upper body dressing ability using a cognitively impaired cohort of stroke participants (n = 70), and to explore the importance of bimanual activity when dressing in the presence of cognitive impairment. Dressing ability was assessed at baseline and immediately following a 6-week period of dressing practice with an occupational therapist. Results: Thirty-six participants were able to use a bimanual dressing method at baseline. The chi-square test for independence indicated a strong association between dressing method (bimanual or unimanual) and independence in upper body dressing, p<0.001. The dressing success of the bimanual group was significantly greater than that of the unimanual group at both assessment time points. Conclusion: Cognitively impaired stroke survivors do perform better at upper body dressing when they are able to use both hands as compared with one, but those with arm paresis preventing bimanual activity may still improve their dressing performance significantly with practice.
Reticulated Organic Photovoltaics
Authors: Schiros Theanne , Mannsfeld Stefan , Chiu Chien‐yang , Yager Kevin G. , Ciston James , Gorodetsky Alon A. , Palma Matteo , Bullard Zac , Kramer Theodore , Delongchamp Dean , Fischer Daniel , Kymissis Ioannis , Toney Michael F. , Nuckolls Colin 
Published: January 2012

AbstractThis paper shows how the self‐assembled interlocking of two nanostructured materials can lead to increased photovoltaic performance. A detailed picture of the reticulated 6‐DBTTC/C60 organic photovoltaic (OPV) heterojunction, which produces devices approaching the theoretical maximum for these materials, is presented from near edge X‐ray absorption spectroscopy (NEXAFS), X‐ray photoelectron spectroscopy (XPS), Grazing Incidence X‐ray diffraction (GIXD) and transmission electron microscopy (TEM). The complementary suite of techniques shows how self‐assembly can be exploited to engineer the interface and morphology between the cables of donor (6‐DBTTC) material and a polycrystalline acceptor (C60) to create an interpenetrating network of pure phases expected to be optimal for OPV device design. Moreover, we find that there is also a structural and electronic interaction between the two materials at the molecular interface. The data show how molecular self‐assembly can facilitate 3‐D nanostructured photovoltaic cells that are made with the simplicity and control of bilayer device fabrication. The significant improvement in photovoltaic performance of the reticulated heterojunction over the flat analog highlights the potential of these strategies to improve the efficiency of organic solar cells.
Pinacol as a New Green Reducing Agent: Molybdenum‐ Catalyzed Chemoselective Reduction of Sulfoxides and Nitroaromatics
Authors: García Nuria , García‐García Patricia , Fernández‐Rodríguez Manuel A. , Rubio Rubén , Pedrosa María R. , Arnáiz Francisco J. , Sanz Roberto 
Published: January 2012

AbstractPinacol is disclosed as a new chemoselective and environmentally benign reducing agent for sulfoxides and nitroaromatics assisted by readily available dichlorodioxomolybdenum(VI) complexes as catalysts. A wide range of substrates including those bearing challenging functional groups has been efficiently and selectively reduced with acetone and water being the only by‐products of these reactions.
Incidence of thromboembolic complications in patients with atrial fibrillation or mechanical heart valves with a subtherapeutic international normalized ratio: A prospective multicenter cohort study
Authors: Dentali Francesco , Pignatelli Pasquale , Malato Alessandra , Poli Daniela , Di Minno Matteo Nicola Dario , Di Gennaro Leonardo , Rancan Elena , Pastori Daniele , Grifoni Elena , Squizzato Alessandro , Siragusa Sergio , Minno Giovanni di , Ageno Walter 
Published: January 2012

AbstractSubtherapeutic international normalized ratio (INR) is frequently encountered in clinical practice, and patients with high‐risk atrial fibrillation (AF) and with mechanical heart valve (MHV) with inadequate anticoagulation may be exposed to an increased risk of thromboembolic events (TE). However, there are no prospective data evaluating this risk. Consecutive patients with a history of stable anticoagulation, but with a subtherapeutic INR, were prospectively included. Data on use and dose of low‐molecular weight heparin (LMWH) bridging therapy were collected. The incidence of objectively confirmed TE and of major bleeding events within 90 days after the index INR was assessed. Five hundred and one patients with INR value 0.5–1 INR units below the lower limit of the patient‐specific target INR were included in the study (280 with MHV and 221 with AF and CHADS2 score ≥3). LMWH was prescribed for 64 patients (12.8%). During follow‐up, seven patients had a TE (1.40%; 95% confidence interval 0.68, 2.86%; 5.58 events for 100 patients year). All the events occurred within 14 days after the index INR. When we consider only patients who did not receive bridging therapy, the incidence of TE was 1.14% (5 of 437 patients; 95% confidence interval 0.49, 2.64%; 4.58 events for 100 patients year). There were no major bleeding events. The risk of TE in this population was not negligible. Given the frequent observation of subtherapeutic INR levels when monitoring vitamin K antagonists, this finding warrants additional investigation to improve the management of these patients. Am. J. Hematol. 2012. © 2012 Wiley Periodicals, Inc.