bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global Precipitation Extremes Associated with Diurnally Varying Low-Level Jets
Authors: Monaghan Andrew J. , Rife Daran L. , Pinto James O. , Davis Christopher A. , Hannan John R. 
Published: May 2010

AbstractExtreme rainfall events have important societal impacts: for example, by causing flooding, replenishing reservoirs, and affecting agricultural yields. Previous literature has documented linkages between rainfall extremes and nocturnal low-level jets (NLLJs) over the Great Plains of North America and the La Plata River basin of South America. In this study, the authors utilize a 21-yr, hourly global 40-km reanalysis based on the fifth-generation Pennsylvania State University–NCAR Mesoscale Model (MM5) to examine whether NLLJ–rainfall linkages are common elsewhere on the earth. The reanalysis is uniquely suited for the task because of its comparatively high spatial and temporal resolution and because a companion paper demonstrated that it realistically simulates the vertical, horizontal, and diurnal structure of the winds in well-known NLLJ regions. The companion paper employed the reanalysis to identify and describe numerous NLLJs across the planet, including several previously unknown NLLJs.The authors demonstrate here that the reanalysis reasonably simulates the diurnal cycle, extremes, and spatial structure of rainfall globally compared to satellite-based precipitation datasets and therefore that it is suitable for examining NLLJ–rainfall linkages. A statistical approach is then introduced to categorize nocturnal precipitation extremes as a function of the NLLJ magnitude, wind direction, and wind frequency for January and July. Statistically significant relationships between NLLJs and nocturnal precipitation extremes exist in at least 10 widely disparate regions around the world, some of which are well known and others that have been undocumented until now. The regions include the U.S. Great Plains, Tibet, northwest China, India, Southeast Asia, southeast China, Argentina, Namibia, Botswana, and Ethiopia. Recent studies have recorded widespread changes in the amplitudes of near-surface diurnal heating cycles that in turn play key roles in driving NLLJs. It will thus be important for future work to address how rainfall extremes may be impacted if trends in diurnal cycles cause the position, magnitude, and frequency of NLLJs to change.
Strengthening of Tropical Indian Ocean Teleconnection to the Northwest Pacific since the Mid-1970s: An Atmospheric GCM Study*
Authors: Huang Gang , Hu Kaiming , Xie Shang-Ping 
Published: May 2010

Abstract
The correlation of northwest (NW) Pacific climate anomalies during summer with El Niño–Southern Oscillation (ENSO) in the preceding winter strengthens in the mid-1970s and remains high. This study investigates the hypothesis that the tropical Indian Ocean (TIO) response to ENSO is key to this interdecadal change, using a 21-member ensemble simulation with the Community Atmosphere Model, version 3 (CAM3) forced by the observed history of sea surface temperature (SST) for 1950–2000. In the model hindcast, the TIO influence on the summer NW Pacific strengthens in the mid-1970s, and the strengthened TIO teleconnection coincides with an intensification of summer SST variability over the TIO. This result is corroborated by the fact the model’s skills in simulating NW Pacific climate anomalies during summer increase after the 1970s shift.
During late spring to early summer, El Niño–induced TIO warming decays rapidly for the epoch prior to the 1970s shift but grows and persists through summer for the epoch occurring after it. This difference in the evolution of the TIO warming determines the strength of the TIO teleconnection to the NW Pacific in the subsequent summer. An antisymmetric wind pattern develops in spring across the equator over the TIO, and the associated northeasterly anomalies aid the summer warming over the north Indian Ocean by opposing the prevailing southwest monsoon. In the model, this antisymmetric spring wind pattern is well developed after but absent before the 1970s shift.
Asymmetry in the Duration of El Niño and La Niña
Authors: Okumura Yuko M. , Deser Clara 
Published: May 2010

Abstract
El Niño and La Niña are not a simple mirror image, but exhibit significant differences in their spatial structure and seasonal evolution. In particular, sea surface temperature (SST) anomalies over the equatorial Pacific cold tongue are larger in magnitude during El Niño compared to La Niña, resulting in positive skewness of interannual SST variations. The associated atmospheric deep convection anomalies are displaced eastward during El Niño compared to La Niña because of the nonlinear atmospheric response to SST. In addition to these well-known features, an analysis of observational data for the past century shows that there is a robust asymmetry in the duration of El Niño and La Niña. Most El Niños and La Niñas develop in late boreal spring/summer, when the climatological cold tongue is intensifying, and they peak near the end of the calendar year. After the mature phase, El Niños tend to decay rapidly by next summer, but many La Niñas persist through the following year and often reintensify in the subsequent winter. Throughout the analysis period, this asymmetric feature is evident for strong events in which Niño-3.4 SST anomalies exceed one standard deviation in December. Seasonally stratified composite analysis suggests that the eastward displacement of atmospheric deep convection anomalies during El Niño enables surface winds in the western equatorial Pacific to be more affected by remote forcing from the Indian Ocean, which acts to terminate the Pacific events.
Observed Characteristics of Hail Size in Four Regions in China during 1980–2005
Authors: Xie Baoguo , Zhang Qinghong , Wang Yuqing 
Published: May 2010

Abstract
The climatology and long-term trend of hail size in four regions of China are documented for the period of 1980–2005 using the maximum hail diameter (MHD) data obtained from the Meteorological Administrations of Xinjiang Uygur Autonomous Region (XUAR), the Inner Mongolia Autonomous Region (IMAR), Guizhou Province, and Hebei Province. The reported MHD is mainly around 10 mm in the four regions. Guizhou (in southwestern China) has the largest proportion of severe hail (MHD greater than 15 mm) among the four regions. Severe hail in southwestern China mainly occurs between February and June, while in northern China it occurs in summer (from May to August) with the peak in June. During the period studied, the size of severe hail shows a slight downtrend in Guizhou and IMAR, whereas it shows an uptrend and a flat trend in Hebei and XUAR, respectively. However, none of the trends is statistically significant. Results from sensitivity experiments using a one-dimensional numerical model show that hail size is sensitive to the freezing level height, the maximum updraft, and column cloud liquid water—all working together to determine the geographic distribution and long-term trend of the observed hail size in China.
Isotopic and Elemental Changes in Winter Snow Accumulation on Glaciers in the Southern Alps of New Zealand
Authors: Purdie Heather , Bertler Nancy , Mackintosh Andrew , Baker Joel , Rhodes Rachael 
Published: May 2010

Abstract
The authors present stable water isotope and trace element data for fresh winter snow from two temperate maritime glaciers located on opposite sides of the New Zealand Southern Alps. The isotopes δ18O and δD were more depleted at the eastern Tasman Glacier site because of prevailing westerly flow and preferential rainout of heavy isotopes as air masses crossed the Alps. The deuterium excess provided some indication of moisture provenance, with the Tasman Sea contributing ∼70% of the moisture received at Franz Josef and Tasman Glaciers. This source signal was also evident in trace elements, with a stronger marine signal (Na, Mg, and Sr) associated with snow from the Tasman Sea and larger concentrations of terrestrial species (Pb, V, and Zr) in air masses from the Southern and Pacific Oceans. Although postdepositional modification of signals was detected, the results indicate that there is exciting potential to learn more about climate trends and moisture source pathways and to learn from geochemical signals contained in snow and ice in the New Zealand region.
Lidar Observations of Aircraft Exhaust Plumes
Authors: Bennett Michael , Christie Simon , Graham Angus , Raper David 
Published: May 2010

Abstract
A series of field campaigns has been made at British airports using a rapid-scanning lidar and other instrumentation in order to measure the dispersion of exhaust plumes from commercial aircraft. The lidar operated at a wavelength of 355 nm and was thus effectively eye safe. Analysis software for the lidar signals has been elaborated to enable the rather weak signals (typically a few tens of percent of ambient backscatter) from aircraft exhaust to be distinguished and to facilitate automatic processing of the measurements obtained. Such processing can deliver images, animations, and numerical parameterizations of the dispersing plumes.
Overall, 1353 air traffic movements were monitored over two campaigns at Manchester and 439 in a single campaign at Heathrow. All modes were observed: taxiing, takeoff, rotation, climb-out, approach, and landing. Of these, the most complete dataset was that obtained for the start of the takeoff run: in this mode, the source is on full power but is still moving relatively slowly. Emissions thus remain at their most concentrated. For the same reason, this is the most important mode in respect to local air quality. Tire smoke on landing was likewise easily detected. Conversely, the lidar could only see the engine emissions from about 30% of the aircraft on approach. These data have been archived in an accessible form and are currently being used to develop improved regulatory dispersion models for airports.
Implementation of the Fit Body and Soul, a Church-Based Life Style Program for Diabetes Prevention in High-Risk African Americans
Authors: Dodani S. , Fields J.Z. 
Published: May 2010

Purpose The purpose of this study was to determine the effects of a behavioral faith-based diabetes prevention program called the Fit Body and Soul program in a semi-urban African-American church using a community-based participatory approach. Methods The 12-session Fit Body and Soul program was modified from the group lifestyle balance intervention that was modified from the successful National Institute of Health (NIH) funded Diabetes Prevention Program. The Fit Body and Soul program was implemented in a semi-urban African-American church community. Based on the results of physical examinations and increased body mass index (BMI ≥ 25), 40 adult members of the church were identified as being at high risk for diabetes. Four church ministers, after receiving Fit Body and Soul program training for 2 days, served as study interventionists. The primary objective was weight loss of at least 5% by the end of the 12-session Fit Body and Soul intervention. Results Screening of church participants was conducted at the Gospel Water Branch Baptist Church in Augusta, Georgia. A total of 40 individuals having a BMI ≥ 25 were selected. Of the 40, a total of 35 (87.5%) attended at least 10 sessions and provided information required for the study. Of the 35, a total of 48% lost at least 5% of baseline weight, 26% lost 7% or more, and 14% lost >10% of baseline weight. Conclusions This pilot trial suggests that carrying out a larger Fit Body and Soul study in a faith-based setting, using behavioral lifestyle interventions, in the context of a diabetes prevention program for African American communities is feasible, as is the possibility that subjects in that larger study will achieve a clinically significant degree of weight loss.
An exploration of the relationship between self-esteem, health knowledge, chronic dieting and body shape accuracy
Authors: Feero Sara Ann Muir , Steadman Liz 
Published: May 2010

Aims: To explore the relationship between self-esteem, health knowledge, chronic dieting and perceived body size and shape. Method: The study design was cross-sectional in nature; 41 women from diet and health clubs participated by completing a questionnaire containing scales that assessed levels of self-esteem, health knowledge and chronic dieting. They also responded to a body shape accuracy instrument that was designed to measure accurately the percentage of over- or underestimation of body size and shape. Results: Correlational analyses showed that there was a statistically significant negative relationship between self-esteem and chronic dieting and a significant positive relationship between chronic dieting and health knowledge. Chi squared (χ 2) analysis revealed that women with higher levels of health knowledge had low self-esteem and that low self-esteem women were significantly more likely than women with high self-esteem to underestimate their body size. Conclusions: Levels of health knowledge and self-esteem appear to play a complex role in chronic dieting and subjective perceptions of body shape and it is an area that warrants further investigation. The body shape scale proved to be a successful instrument and further trials using this scale are recommended.
Working as a community food worker: Voices from the inside
Authors: Coufopoulos Anne , Coffey Margaret , Dugdill Lindsey 
Published: May 2010

Aims: Community food worker (CFW) is one of the new roles that were proposed in the 2004 White Paper Choosing Health: Making Healthier Choices Easier. CFWs are recruited from local communities and generally operate in areas characterized by extreme social deprivation. The aim of this paper is to illuminate the experience of being a CFW in the context of working in a relatively new non-professional role. Methods: As part of an ongoing evaluation of a CFW scheme in the north west of England, a qualitative interview and two focus groups were conducted with CFWs. Thematic analysis of the data was undertaken. Results: Emergent issues faced by these new practitioners include: the nature of their role; quantifying success; working with other health professionals; skills and knowledge; and strategies used to work with communities. Conclusion: This study has highlighted some pertinent and previously unreported issues related to the experience of being a CFW, raising questions about their assimilation into the public health workforce and their use in delivering effective public health interventions without further integration.
Scavenger receptor BI modulates platelet reactivity and thrombosis in dyslipidemia
Authors: Ma Yi , Ashraf Mohammad Z. , Podrez Eugene A. 
Published: May 2010

AbstractHypercholesterolemia is associated with increased platelet sensitivity to agonists and a prothrombotic phenotype. Mechanisms of platelet hypersensitivity are poorly understood; however, increased platelet cholesterol levels associated with hypercholesterolemia were proposed as leading to hypersensitivity. Scavenger receptor class B type I (SR-BI) in the liver controls plasma high-density lipoprotein (HDL) levels, and SR-BI–deficient mice display a profound dyslipoproteinemia. SR-BI is also expressed on platelets, and recent studies have suggested a role for SR-BI in platelet function; however, its role in hemostasis is unknown. Our present studies demonstrated that non-bone marrow–derived SR-BI deficiency and the dyslipidemia associated with it lead to platelet hyperreactivity that was mechanistically linked to increased platelet cholesterol content. Platelet-specific deficiency of SR-BI, on the other hand, was associated with resistance to hyperreactivity induced by increased platelet cholesterol content. Intravital thrombosis studies demonstrated that platelet SR-BI deficiency protected mice from prothrombotic phenotype in 2 types of dyslipidemia associated with increased platelet cholesterol content. These novel findings demonstrate that SR-BI plays dual roles in thrombosis and may contribute to acute cardiovascular events in vivo in hypercholesterolemia.
TargetSpy: a supervised machine learning approach for microRNA target prediction
Authors: Sturm Martin , Hackenberg Michael , Langenberger David , Frishman Dmitrij 
Published: May 2010

Abstract

Background
Virtually all currently available microRNA target site prediction algorithms require the presence of a (conserved) seed match to the 5' end of the microRNA. Recently however, it has been shown that this requirement might be too stringent, leading to a substantial number of missed target sites.

Results
We developed TargetSpy, a novel computational approach for predicting target sites regardless of the presence of a seed match. It is based on machine learning and automatic feature selection using a wide spectrum of compositional, structural, and base pairing features covering current biological knowledge. Our model does not rely on evolutionary conservation, which allows the detection of species-specific interactions and makes TargetSpy suitable for analyzing unconserved genomic sequences.
In order to allow for an unbiased comparison of TargetSpy to other methods, we classified all algorithms into three groups: I) no seed match requirement, II) seed match requirement, and III) conserved seed match requirement. TargetSpy predictions for classes II and III are generated by appropriate postfiltering. On a human dataset revealing fold-change in protein production for five selected microRNAs our method shows superior performance in all classes. In Drosophila melanogaster not only our class II and III predictions are on par with other algorithms, but notably the class I (no-seed) predictions are just marginally less accurate. We estimate that TargetSpy predicts between 26 and 112 functional target sites without a seed match per microRNA that are missed by all other currently available algorithms.

Conclusion
Only a few algorithms can predict target sites without demanding a seed match and TargetSpy demonstrates a substantial improvement in prediction accuracy in that class. Furthermore, when conservation and the presence of a seed match are required, the performance is comparable with state-of-the-art algorithms. TargetSpy was trained on mouse and performs well in human and drosophila, suggesting that it may be applicable to a broad range of species. Moreover, we have demonstrated that the application of machine learning techniques in combination with upcoming deep sequencing data results in a powerful microRNA target site prediction tool http://www.targetspy.org.
Identification of the heart as the critical site of adenosine mediated embryo protection
Authors: Wendler Christopher C , Poulsen Ryan R , Ghatpande Satish , Greene Robert W , Rivkees Scott A 
Published: May 2010

AbstractBackgroundOur understanding of the mechanisms that protect the developing embryo from intrauterine stress is limited. Recently, adenosine has been demonstrated to play a critical role in protecting the embryo against hypoxia via adenosine A1 receptors (A1ARs), which are expressed in the heart, nervous system, and other sites during development. However, the sites of A1AR action that mediate embryo protection are not known. To determine if the heart is a key site of adenosine-mediated embryo protection, A1ARs were selectively deleted in the embryonic heart using a Cre-LoxP system in which the alpha-myosin heavy chain promoter drives Cre-recombinase expression and excision of the A1AR gene from cardiomyocytes.ResultsWith increasing exposure of maternal hypoxia (10% O2) from 48-96 hours beginning at embryonic day (E) 8.5, embryo viability decreased in the cardiac-A1AR deleted embryos. 48 hours of hypoxia reduced embryonic viability by 49% in embryos exposed from E10.5-12.5 but no effect on viability was observed in younger embryos exposed to hypoxia from E8.5-10.5. After 72 hours of hypoxia, 57.8% of the cardiac-A1AR deleted embryos were either dead or re-absorbed compared to 13.7% of control littermates and after 96 hours 81.6% of cardiac-A1AR deleted embryos were dead or re-absorbed. After 72 hours of hypoxia, cardiac size was reduced significantly more in the cardiac-A1AR deleted hearts compared to controls. Gene expression analysis revealed clusters of genes that are regulated by both hypoxia and A1AR expression.ConclusionsThese data identify the embryonic heart as the critical site where adenosine acts to protect the embryo against hypoxia. As such these studies identify a previously unrecognized mechanism of embryo protection.
Prevalence of Borrelia burgdorferi sensu lato in rodents from Gansu, northwestern China
Authors: Zhang Fang , Gong Zhanwei , Zhang Jijun , Liu Zengjia 
Published: May 2010

Abstract

Background
Lyme disease is a multi-organ infection disease caused by Borrelia burgdorferi sensu lato. Lyme disease was first documented in north-east China in 1986. Since then more than 20 provinces in China were confirmed the existence of nature foci of Lyme disease. In the present study, a molecular epidemiological survey was conducted to investigate the presence of Borrelia burgdorferi sensu lato in rodents from Gansu Province for the first time.

Result
A total of 140 rodents of 7 species were examined for Borrelia burgdorferi sensu lato. by nested-PCR and culture isolation. The overall infection rate was 22.86%. Two rodent species most frequently trapped were responsible for all positive. 3 strains were isolated from Apodemus agrarius, which belonged to B. garinii, 1 strain isolated from Rattus losea was identified as B. afzelii.

Conclusion
The study firstly showed the role of rodents in maintaining the pathogen of Lyme disease in the environment from Gansu Province and there existed at least two genotypes of Lyme disease spirochaetes in rodents.
Imbalances in serum angiopoietin concentrations are early predictors of septic shock development in patients with post chemotherapy febrile neutropenia
Authors: Alves Brunna E , Montalvao Silmara AL , Aranha Franciso JP , Siegl Tania FG , Souza Carmino A , Lorand-Metze Irene , Annichino-Bizzacchi Joyce M , De Paula Erich V 
Published: May 2010

Abstract

Background
Febrile neutropenia carries a high risk of sepsis complications, and the identification of biomarkers capable to identify high risk patients is a great challenge. Angiopoietins (Ang -) are cytokines involved in the control microvascular permeability. It is accepted that Ang-1 expression maintains endothelial barrier integrity, and that Ang-2 acts as an antagonizing cytokine with barrier-disrupting functions in inflammatory situations. Ang-2 levels have been recently correlated with sepsis mortality in intensive care units.

Methods
We prospectively evaluated concentrations of Ang-1 and Ang-2 at different time-points during febrile neutropenia, and explored the diagnostic accuracy of these mediators as potential predictors of poor outcome in this clinical setting before the development of sepsis complications.

Results
Patients that evolved with septic shock (n = 10) presented higher levels of Ang-2 measured 48 hours after fever onset, and of the Ang-2/Ang-1 ratio at the time of fever onset compared to patients with non-complicated sepsis (n = 31). These levels correlated with sepsis severity scores.

Conclusions
Our data suggest that imbalances in the concentrations of Ang-1 and Ang-2 are independent and early markers of the risk of developing septic shock and of sepsis mortality in febrile neutropenia, and larger studies are warranted to validate their clinical usefulness. Therapeutic strategies that manipulate this Ang-2/Ang-1 imbalance can potentially offer new and promising treatments for sepsis in febrile neutropenia.