bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prolonged Antigen Storage Endows Merocytic Dendritic Cells with Enhanced Capacity To Prime Anti-Tumor Responses in Tumor-Bearing Mice
Authors: Reboulet Rachel A. , Hennies Cassandra M. , Garcia Zacarias , Nierkens Stefan , Janssen Edith M. 
Published: August 2010

Abstract
Tumor cell vaccination with irradiated autologous tumor cells is a promising approach to activate tumor-specific T cell responses without the need for tumor Ag identification. However, uptake of dying cells by dendritic cells (DCs) is generally a noninflammatory or tolerizing event to prevent the development of autoreactive immune responses. In this study, we describe the mechanisms that confer the potent T cell priming capacity of a recently identified a population of DCs (merocytic DCs [mcDCs]) that potently primes both CD8+ and CD4+ T cells to cell-associated Ags upon uptake of apoptotic cells. mcDCs acquired cell-associated materials through a process of merocytosis that is defined by the uptake of small particles that are stored in nonacidic compartments for prolonged periods, sustained Ag presentation, and the induction of type I IFN. T cells primed by mcDCs to cell-associated Ags exhibit increased primary expansion, enhanced effector function, and increased memory formation. By using transgenic T cell transfer models and endogenous models, we show that treatment of tumor-bearing mice with mcDCs that have been exposed to dying tumor cells results in tumor suppression and increased host survival through the activation of naive tumor-specific CD8+ T cells as well as the reinvigoration of tumor-specific T cells that had been rendered nonresponsive by the tumor in vivo. The potent capacity of mcDCs to prime both CD4+ and CD8+ T cells to cell-associated Ags under immunosuppressive conditions makes this DC subset an attractive target for tumor therapies as well as interventional strategies for autoimmunity and transplantation.
Nonmalignant Clonal Expansions of Memory CD8+ T Cells That Arise with Age Vary in Their Capacity To Mount Recall Responses to Infection
Authors: Kohlmeier Jacob E. , Connor Lisa M. , Roberts Alan D. , Cookenham Tres , Martin Kyle , Woodland David L. 
Published: August 2010

Abstract
Immune responsiveness declines with age in part due to the development of CD8+ T cell clonal expansions (TCEs) that can dominate the peripheral T cell pool. Although some TCEs arise due to persistent Ag stimulation from chronic infections, others arise in the apparent absence of chronic infection. We have recently shown that this latter class of TCEs can arise over time from the memory CD8+ T cell pool established by an acute viral infection. Unlike TCEs driven by chronic infections, these age-related TCEs do not display the phenotypic and in vitro functional characteristics of exhausted cells. However, the rate at which these age-related TCEs develop from the memory CD8+ T cell pool, as well as their ability to mount a recall response to secondary pathogen challenge in vivo, is not known. In this study, we analyzed large cohorts of mice over time for the development of TCE following Sendai virus infection and found a progressive increase in the appearance of TCEs, such that most mice showed evidence of TCE within the memory T cell pool by 2 y postinfection. Using a dual adoptive transfer approach to address the recall potential of virus-specific TCEs, we also demonstrate that most TCEs examined are poorly responsive to a secondary infection. Therefore, we provide evidence that the development of TCE is a common occurrence due to the progressive dysregulation of the virus-specific memory T cell pool with age, but many TCEs are profoundly defective in their ability to mediate recall responses.
Assessment of the natural history of forefoot bursae using ultrasonography in patients with rheumatoid arthritis: A twelve‐month investigation
Authors: Bowen Catherine J. , Hooper Lindsey , Culliford David , Dewbury Keith , Sampson Madeleine , Burridge Jane , Edwards Christopher J. , Arden Nigel K. 
Published: August 2010

AbstractObjectiveTo determine the natural history and clinical significance of forefoot bursae over a 12‐month period in patients with rheumatoid arthritis (RA).MethodsPatients with RA (n = 149) attending rheumatology outpatient clinics were assessed at baseline. A total of 120 participants, mean ± SD age 60.7 ± 12.1 years and mean ± SD disease duration 12.99 ± 10.4 years, completed the 12‐month followup (98 women, 22 men, 93 rheumatoid factor positive, 24 rheumatoid factor negative, and 3 unknown). Musculoskeletal ultrasound (US) was used to identify forefoot bursae in all of the participants. Clinical markers of disease activity (well‐being visual analog scale [VAS], erythrocyte sedimentation rate [ESR], C‐reactive protein [CRP] level, and Disease Activity Score in 28 joints [DAS28]) and foot symptoms on the Leeds Foot Impact Scale (LFIS) Questionnaire were recorded on both occasions.ResultsPresence of US‐detectable forefoot bursae was identified in 93.3% of returnee (n = 120) participants (individual mean 3.7, range 0–11) at baseline. Significant associations were identified between bursae presence and patient‐reported foot impact for impairment/footwear (LFISIF; baseline: r = 0.226, P = 0.013 and 12 months: r = 0.236, P = 0.009) and activity limitation/participation restriction (LFISAP; baseline: r = 0.254, P = 0.005 and 12 months: r = 0.235, P = 0.010). After 12 months, 42.5% of participants had an increase in the number of US‐detectable forefoot bursae and 45% of participants had a decrease. Changes in bursae number significantly correlated with changes in LFISIF (r = 0.216, P = 0.018) and LFISAP (r = 0.193, P = 0.036). No significant associations were identified between changes in bursae and changes in global well‐being VAS, ESR, CRP level, or DAS28.ConclusionThe findings of this study suggest that forefoot bursae may regress or hypertrophy over time in patients with RA, and that these changes may be associated with self‐reported foot impairment and activity restriction.
Emotional, physical, and sexual abuse in fibromyalgia syndrome: A systematic review with meta‐analysis
Authors: Häuser Winfried , Kosseva Maria , Üceyler Nurcan , Klose Petra , Sommer Claudia 
Published: August 2010

AbstractObjectiveTo systematically assess the potential association of fibromyalgia syndrome (FMS) with emotional, physical, and sexual abuse.MethodsThe databases EMBase, Google Scholar, Medline, and PsycINFO (through April 2010) and the reference sections of original studies were searched for eligible studies. Eligible studies were cohort or case–control studies that assessed at least one type of emotional, physical, or sexual abuse in childhood or adulthood in patients with FMS and in controls. Two authors independently extracted descriptive, quality, and outcome data from included studies. Methodologic quality was assessed by the Newcastle‐Ottawa Quality Assessment Scale. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were pooled across studies by using the random‐effects model. Heterogeneity was assessed by I2 statistics.ResultsThe search identified 18 eligible case–control studies with 13,095 subjects. There were significant associations between FMS and self‐reported physical abuse in childhood (OR 2.49 [95% CI 1.81–3.42], I2 = 0%; 9 studies) and adulthood (OR 3.07 [95% CI 1.01–9.39], I2 = 79%; 3 studies), and sexual abuse in childhood (OR 1.94 [95% CI 1.36–2.75], I2 = 20%; 10 studies) and adulthood (OR 2.24 [95% CI 1.07–4.70], I2 = 64%; 4 studies). Study quality was mostly poor. Low study quality was associated with higher effect sizes for sexual abuse in childhood, but not with other effect sizes.ConclusionThe association of FMS with physical and sexual abuse could be confirmed, but is confounded by study quality.
Do spouses know how much fatigue, pain, and physical limitation their partners with rheumatoid arthritis experience? Implications for social support
Authors: Lehman Allen J. , Pratt Daniel D. , DeLongis Anita , Collins John B. , Shojania Kam , Koehler Barry , Offer Robert , Esdaile John M. 
Published: August 2010

AbstractObjectiveTo determine whether perceptions of clinical manifestations (fatigue, pain, and physical limitation) of rheumatoid arthritis (RA) differ between spouses and their partners with RA, and to determine whether the differences are associated with the perception of beneficial and problematic spousal social support.MethodsEnglish‐speaking adults with RA of ≥6 months' duration and their spouses (n = 222 couples) completed standardized questionnaires for fatigue, pain, physical limitation, beneficial spousal support, and problematic spousal support. Spouses completed questionnaires based on their perception of their partner with RA. Agreement scores for fatigue, pain, and physical limitation were calculated by subtracting spouse scores from the scores of the partner with RA. Agreement levels were defined a priori: agreement (within ± one‐half of a minimum clinically important difference [MCID] unit), overestimator (< one‐half an MCID), and underestimator (> one‐half an MCID). Separate hierarchical linear regression models were used to measure the association between beneficial support and problematic support after adjusting for RA duration, physical health, sex, educational level, relationship duration, and satisfaction.ResultsResponse rate for couples was 82%. Relative to participants with RA, spouses overestimated fatigue (26%), pain (29%), and physical limitation (39%), and underestimated fatigue (11%), pain (17%), and physical limitation (34%). After statistically controlling for demographic, disease, and psychosocial variables, participants with RA whose spouses underestimated fatigue received more problematic support (R2 = 3.7%, P = 0.002), as did those whose spouses underestimated or overestimated physical limitation (R2 = 3.4%, P = 0.017).ConclusionPersons with RA perceived more problematic spousal support when their spouse underestimated fatigue, or underestimated or overestimated physical limitation levels.
Prophylactic antibiotics for the prevention of neutropenic fever in patients undergoing autologous stem‐cell transplantation: Results of a single institution, randomized phase 2 trial
Authors: Eleutherakis‐Papaiakovou Evangelos , Kostis Evangelos , Migkou Magda , Christoulas Dimitrios , Terpos Evangelos , Gavriatopoulou Maria , Roussou Maria , Bournakis Evangelos , Kastritis Efstathios , Efstathiou Eleni , Dimopoulos Meletios A. , Papadimitriou Christos A. 
Published: August 2010

AbstractOne hundred and fifty‐seven patients undergoing high‐dose chemotherapy (HDT) and autologous stem‐cell transplantation (ASCT) for hematopoietic malignancies and solid tumors were randomly assigned to receive (Group A) or not (Group B) prophylaxis with ciprofloxacin, orally, and vancomycin, intravenously. Prophylactic antibiotics were given from day 0 until resolution of neutropenia or the appearance of a febrile event. Furthermore, patients in both groups received once a day fluconazole, orally. The primary end‐point of our study was the incidence of neutropenic febrile episodes attributed to infection. One hundred and twelve (71.3%) patients developed neutropenic fever, 50 (56.2%) in Group A and 62 (91.2%) in Group B (P < 0.001) with the majority (82%) of patients developing fever of unknown origin. Patients on prophylactic antibiotics had a significantly lower rate of bacteremias (5.6%) than did those randomized to no prophylaxis (29.4%) (P = 0.005) and, when developing neutropenic fever, they had a lower probability of response to first‐line empirical antibiotics (P = 0.025). Prophylactic administration of ciprofloxacin and vancomycin reduced the incidence of neutropenic fever in patients receiving HDT with ASCT, however, without affecting the total interval of hospitalization, time to engraftment, or all‐cause mortality. Therefore, our results do not support the use of antibiotic prophylaxis for patients undergoing HDT and ASCT. Am. J. Hematol., 2010. © 2010 Wiley‐Liss, Inc.
A case of occupational peritoneal mesothelioma from exposure to tremolite‐free chrysotile in Quebec, Canada: A black swan case
Authors: Egilman David , Menéndez Lelia M. 
Published: August 2010

AbstractBackgroundTremolite contamination has been proposed as the cause of mesothelioma in workers exposed to commercial chrysotile. The asbestos industry and scientists it has sponsored, for example, have argued that commercial chrysotile does not cause peritoneal mesothelioma.MethodCase report of peritoneal mesothelioma in a mill worker from a tremolite free Canadian mine.ResultsReports from pathology and occupational health and safety panels conclude that this mill worker developed work‐related peritoneal mesothelioma.ConclusionChrysotile without tremolite can cause peritoneal mesothelioma. Am. J. Ind. Med. 54:153–156, 2011. © 2010 Wiley‐Liss, Inc.
The estimated national burden of physical ergonomic hazards among US workers
Authors: Tak SangWoo , Calvert Geoffrey M. 
Published: August 2010

AbstractPurposeTo estimate the national burden of physical ergonomic hazards among working adults in the US.MethodsWe estimated the population prevalence of and the total number of workers who are exposed to physical ergonomic hazards, such as vibration, working in cramped space, kneeling, body bending or twisting, climbing, and repetitive motions using Occupational Information Network (O*NET) data and the Occupational Employment Statistics (OES) from the U.S. Bureau of Labor Statistics (BLS) stratified by occupation title.ResultsRepetitive motion was the most prevalent of all ergonomic hazards (27% of US workers are estimated to be exposed continually). Bending or twisting of the body more than half their time at work was also common, involving over 32 million US workers (25% of US workforce). Kneeling, crouching, stooping, or crawling was another ergonomic hazard that 14 million US workers perform more than half their time at work. Almost 4 million workers climb ladders, scaffolds, poles, etc. for more than half their time at work. We estimate that over 13 million workers (10% of US workforce) were exposed to cramped workspace that requires getting into awkward positions every day. Finally, about 3.5 million workers (2.7% of US workforce) were estimated to be exposed to whole body vibration every day.ConclusionA large portion of the US work force is exposed to ergonomic hazards known to be associated with musculoskeletal disorders (MSDs). The occupations with the highest prevalence of each ergonomic hazard may be deserving of prompt efforts toward prevention of MSDs. Am. J. Ind. Med. 54:395–404, 2011. © 2010 Wiley‐Liss, Inc.
Work‐relatedness of selected chronic medical conditions and workers' compensation utilization: National health interview survey occupational health supplement data
Authors: Luckhaupt Sara E. , Calvert Geoffrey M. 
Published: August 2010

AbstractBackgroundAn occupational health supplement (OHS) to the 1988 National Health Interview Survey (NHIS) bypassed many limitations of traditional occupational health surveillance systems, but the data collected about chronic work‐related conditions have not yet been reported.MethodsWe calculated the prevalence and proportion of cases related to work for the aggregation of 13 chronic conditions included in the NHIS‐OHS, and for 11 conditions individually. For each of nine conditions, and for the aggregation of all conditions, we also calculated the prevalence of workers' compensation claims filed.ResultsThe overall prevalence of work‐related chronic conditions was 7.5% (SE = 0.16). The work‐related conditions with the highest prevalence were repeated trouble with the back/neck/spine (4.91%; SE = 0.13) and trouble hearing (1.14%; SE = 0.06). Overall, workers' compensation claims were filed for 39.0% (SE = 1.00) of work‐related cases.ConclusionsThe burden of work‐related illnesses in the US is substantial, and the workers' compensation system is underutilized. Am. J. Ind. Med. 53:1252–1263, 2010. © 2010 Wiley‐Liss, Inc.
Diverse morphologies of PVDF hollow fiber membranes and their performance analysis as gas/liquid contactors
Authors: Feng Chunsheng , Wang Rong , Zhang Hongyan , Shi Lei 
Published: August 2010

AbstractA systematic investigation on the morphology development of polyvinylidene fluoride hollow fiber membrane made using various N‐methyl‐2‐pyrrolidone (NMP) aqueous solutions as an inner coagulant was carried out. The cross‐sectional and inner surface morphology were analyzed with scanning electronic microscopy (SEM). It is found that with increase on NMP concentration, the morphology of the resultant membranes gradually shifted from a double‐skin to a single‐skin structure. When 40.0 ∼ 55.0 wt.% NMP solution was used, some unexpected macrovoids near the inner region were observed. This special morphology feature was attributed to the reduced solidification rate of the inner surface as a result of increase on NMP concentration, which sharply weakened the inner skin strength. While the existence of centralized stress formed in the phase inversion process, such as shrinkage stress from syneresis, resulted in fractured points in the nascent skin surface that finally made it difficult to maintain a uniform structure. Investigations on effects of the dope flow rate and the bore fluid velocity on the morphology of PVDF fiber membranes experimentally confirmed the suggestion. Three model membranes with double skins, single skin and single skin with macrovoids structures, respectively, were used to test their permeation performance in a CO2 membrane contactor system. The experimental results show the membranes without an inner skin present higher permeability and lower mass transfer resistance than the membrane with a double skin structure. © 2010 Wiley Periodicals, Inc. Journal of Applied Polymer Science, 2010
Crystallization behavior and foaming properties of polypropylene containing ultra‐high molecular weight polyethylene under supercritical carbondioxide
Authors: Xin Chunling , He Yadong , Li Qingchun , Huang Yingzhu , Yan Baorui , Wang Xiaodong 
Published: August 2010

AbstractIn this study, a systematic investigation on the nonisothermal crystallization kinetics of conversional polypropylene (PP) containing various amounts of ultra‐high molecular weight polyethylene (UHMWPE) was reported, and the effects of UHMWPE on crystallization behavior of these PP materials and their foaming properties were also presented. The kinetic studies revealed that the incorporation of UHMWPE into PP led to an increase in the crystallization temperature and temperature range during the crystallization process as well as the relative crystallinity. This behavior was attributed to a comprehensive effect of the nucleation and entanglement of the UHMWPE chains. The kinetic models based on Ozawa's and Mo's methods were used to analyze the nonisothermal crystallization behaviors. It was found that the latter succeeded in describing the nonisothermal crystallization behavior of the PP containing UHMWPE, while the former was not appropriate. The activation energy for the nonisothermal crystallization determined by Kissinger's method also indicated that the crystallization ability of PP was improved with the addition of UHMWPE. Owing to the modification of the crystallization kinetics of the PP materials by introduction of UHMWPE, the foaming properties (i.e., cell uniformity and expandability etc.) were improved significantly. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Formulation and in vitro evaluation of transdermal delivery of zidovudine—An anti‐HIV drug
Authors: Mundargi Raghavendra C. , Babu V. Ramesh , Rangaswamy Vidhya , Aminabhavi Tejraj M. 
Published: August 2010

AbstractThis study was designed to develop matrix type of transdermal‐controlled delivery system for zidovudine using Eudragit L100 by varying the amounts of drug in addition to polyethylene glycol as a plasticizer and Tween 80® as a penetration enhancer. Transparent smooth and flexible films were characterized for weight, thickness uniformity, and drug content. Drug interactions with the polymer films were studied by differential scanning calorimetry, whereas X‐ray diffraction was used to understand the drug polymorphism in the films. The in vitro drug release experiments were performed in phosphate buffer using the Keshary‐Chien diffusion cell. Variations of drug release profiles were analyzed using the Ritger and Peppas empirical equation to describe the type of release mechanism. The exponent n values of the equation varied over the wide range of 0.75–2.23, suggesting non‐Fickian to super Case‐II type of diffusion transport. Statistical analyses of release data performed by the analysis of variance (ANOVA) method indicated significant differences within experimental measurements. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Montmorillonite‐filled nanocomposites of tung oil/styrene/divinylbenzene polymers prepared by thermal polymerization
Authors: Kundu P. P. , Larock R. C. 
Published: August 2010

AbstractMontmorillonite‐filled nanocomposites were prepared by the thermal copolymerization of tung oil (TUNG), styrene (ST), and divinylbenzene (DVB). These nanocomposites were characterized by X‐ray diffraction (XRD), transmission electron microscopy (TEM), dynamic mechanical analysis (DMA), and their mechanical properties. The XRD of the modified montmorillonite exhibited a peak that vanished completely in the nanocomposites. Thus, the XRD results apparently indicate a distortion of the platy layers of the nanofiller in the TUNG–ST–DVB polymers. A platy nanolayered structure of the modified montmorillonite in the TUNG–ST–DVB polymers was observed by TEM. The extent of separation of the platy layers as observed by the TEM reached a maximum for the 5% modified nanofiller (at a fixed polymer composition), 50%‐oil‐containing polymer (at a fixed nanofiller concentration of 5%), and TUNG intragallery nanocomposites (at both fixed polymer and nanofiller concentrations). The DMA results show a broadened glass‐transition temperature along with a hump for these nanofilled polymers, indicating the presence as a majority constituent of a copolymer consisting of TUNG and aromatics, along with a grafted TUNG polymer, respectively. The improvements in the Young's modulus and compressive strength upon incorporation of the nanofiller indicated the presence of a partially intercalated and distorted platy‐layered structure of the nanofiller. However, from the results of all of these studies, it was tough to estimate the exact level of delamination/exfoliation in these TUNG nanocomoposites. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Synthesis, characterization, and preliminary antimicrobial evaluation of bisphenol‐A formaldehyde resin coordinated with transition metal complexes of ethylenediamine
Authors: Nishat Nahid , Asma  , Manisha  
Published: August 2010

AbstractCoordination polymers containing bisphenol‐A, formaldehyde, and transition metal complexes of ethylenediamine [M(en)2] were synthesized by the reaction of bisphenol‐A, formaldehyde, and M(en)2 complex in alkaline medium, using M for Fe+3, Co+2, Ni+2, Cu+2, and Zn+2. The materials were characterized by elemental analysis, FTIR, UV–Vis, 1H‐NMR spectra, TGA, and magnetic susceptibility measurement. The geometry of the central metal ions was determined by electronic spectral studies and magnetic moment measurement. The MN and CN bonds were confirmed by the IR spectra of the polychelates. The 1H‐NMR spectra of the chelating resins confirmed polycondensation with well‐defined peaks for bridging methylene functions. Complexation studies with transition metal ions revealed effective coordination of the bisphenol‐A formaldehyde resin. The antimicrobial activities of these chelated resins were screened against E. coli, S. dysantrea (bacteria), and C. albicans, A. niger (fungi) by using agar well diffusion method. All the polymeric chelates show promising antimicrobial activities. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011