bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Preliminary Pharmacological Investigation of New N‐Substituted‐N‐[ω‐(ω‐phenoxy‐alkylpiperazin‐1‐yl)alkyl]guanidines as Non‐Imidazole Histamine H3 Antagonists
Authors: Staszewski Marek , Walczyński Krzysztof 
Published: March 2012

AbstractNovel, potent non‐imidazole histamine H3 receptor antagonists were prepared. Detailed structure–activity studies revealed that N‐(4‐trifluoromethylbenzyl)‐N‐[4‐(7‐phenoxyheptylpiperazin‐1‐yl)butyl]guanidine (pA2 = 8.49 ± 0.05), 1h, and N‐(4‐nitrobenzyl)‐N‐[4‐(7‐phenoxyheptylpiperazin‐1‐yl)butyl]guanidine (pA2 = 8.43 ± 0.05), 1l, exhibit high affinity for the H3 histamine receptor. The most potent antagonists in this series, 1e, 1h, and 1l, were also in vitro tested as H1 receptor antagonists, showing weak H1‐antagonistic activity with pA2 = 6.70 ± 0.09, pA2 = 6.46 ± 0.09, and pA2 = 6.65 ± 0.11, respectively.
Friedel–Crafts Acylation on Graphene
Authors: Chua Chun Kiang , Pumera Martin 
Published: March 2012

AbstractThere is an excitement around graphene as a promising new material for nanotechnological and nanoarchitectonic applications. Despite the low chemical reactivity of graphene, chemical functionalization remains a prominent and viable solution to tailor its chemical, physical, and electronic properties. Herein, we report the covalent functionalization of reduced graphene oxide through Friedel–Crafts reactions under mild conditions of polyphosphoric‐acid/phosphorus‐pentoxide and 4‐aminobenzoic acid. Successful functionalization was confirmed by X‐ray photoelectron spectroscopy (XPS), FTIR, and Raman spectroscopy. The success of the Friedel–Crafts reaction provides an important expansion of the synthetic “toolbox” for future modifications of graphene towards the specific needs of different applications.
The Cognitive Processes Underlying Risky Choice
Authors: Brandstätter Eduard , Gussmack Manuela 
Published: March 2012

ABSTRACTIn this article, we tested two concepts of decision making: expected utility theory and heuristic choice. In Experiment 1, we applied think‐aloud protocols to investigate violations of expected utility theory. In Experiments 2 to 4, we introduced a new process‐tracing method—called predict‐aloud protocols—that has advantages over previously suggested research methods. Results show the following: (i) people examine information between rather than within gambles; (ii) the priority heuristic emerges as the most frequently used strategy when problems are difficult; and (iii) people check for similarity when problems are easy. Copyright © 2012 John Wiley & Sons, Ltd.
Super‐resolution imaging prompts re‐thinking of cell biology mechanisms
Authors: Saka Sinem , Rizzoli Silvio O. 
Published: March 2012

AbstractThe use of super‐resolution imaging techniques in cell biology has yielded a wealth of information regarding cellular elements and processes that were invisible to conventional imaging. Focusing on images obtained by stimulated emission depletion (STED) microscopy, we discuss how the new high‐resolution data influence the ways in which we use and interpret images in cell biology. Super‐resolution images have lent support to some of our current hypotheses. But, more significantly, they have revealed unexpectedly complex processes that cannot be accounted for by the simpler models based on diffraction‐limited imaging. The super‐resolution imaging data challenge cell biologists to change their theoretical framework, by including, for instance, interpretations that describe multiple functions, functional errors or lack of function for cellular elements. In this context, we argue that descriptive research using super‐resolution microscopy is now as necessary as hypothesis‐driven research.
Immunofluorescent spectral analysis reveals the intrathecal cannabinoid agonist, AM1241, produces spinal anti‐inflammatory cytokine responses in neuropathic rats exhibiting relief from allodynia
Authors: Wilkerson Jenny L. , Gentry Katherine R. , Dengler Ellen C. , Wallace James A. , Kerwin Audra A. , Kuhn Megan N. , Zvonok Alexander M. , Thakur Ganesh A. , Makriyannis Alexandros , Milligan Erin D. 
Published: March 2012

AbstractDuring pathological pain, the actions of the endocannabinoid system, including the cannabinoid 2 receptor (CB2R), leads to effective anti‐allodynia and modifies a variety of spinal microglial and astrocyte responses. Here, following spinal administration of the CB2R compound, AM1241, we examined immunoreactive alterations in markers for activated p38 mitogen‐activated protein kinase, interleukin‐1β (IL‐1β), the anti‐inflammatory cytokine, interleukin‐10 (IL‐10) as well as degradative endocannabinoid enzymes, and markers for altered glial responses in neuropathic rats. In these studies, the dorsal horn of the spinal cord and dorsal root ganglia were examined. AM1241 produced profound anti‐allodynia with corresponding immunoreactive levels of p38 mitogen‐activated kinase, IL‐1β, IL‐10, the endocannabinoid enzyme monoacylglycerol lipase, and astrocyte activation markers that were similar to nonneuropathic controls. In contrast, spinal AM1241 did not suppress the increased microglial responses observed in neuropathic rats. The differences in fluorescent markers were determined within discrete anatomical regions by applying spectral analysis methods, which virtually eliminated nonspecific signal during the quantification of specific immunofluorescent intensity. These data reveal expression profiles that support the actions of intrathecal AM1241 control pathological pain through anti‐inflammatory mechanisms by modulating critical glial factors, and additionally decrease expression levels of endocannabinoid degradative enzymes.
A Bond Path and an Attractive Ehrenfest Force Do Not Necessarily Indicate Bonding Interactions: Case Study on M2X2(M=Li, Na, K; X=H, OH, F, Cl)
Authors: Dem'yanov Piotr , Polestshuk Pavel 
Published: March 2012

AbstractInteractions in dimers of model alkali metal derivatives M2X2(M=Li or Na or K; X=H or F, Cl, OH) are studied in the frame of the quantum theory of atoms in molecules (QTAIM) using the interacting quantum atoms approach (IQA). Contrary to opinion prevalent in QTAIM studies, the interaction between two anions linked by a bond path is demonstrated to be strongly repulsive. One may therefore say that a bond path does not necessarily indicate bonding interactions. The interactions between two anions or two cations that are not linked by a bond path are also strongly repulsive. The repulsive anion–anion and cation–cation interactions are outweighed by much stronger attractive anion–cation interactions, and the model molecules are therefore in a stable state. The attractive Ehrenfest forces (calculated in the frame of the QTAIM) acting across interatomic surfaces shared by anions in the dimers do not reflect the repulsive interactions between anions. Probable reasons of this disagreement are discussed. The force exerted on the nucleus and the electrons of a particular atom by the nucleus and the electrons of any another atom in question is proposed. It is assumed that this force unambiguously exposes whether basins of two atoms are attracted or repelled by each other in a polyatomic molecule.
Supported Pd–Cu Bimetallic Nanoparticles That Have High Activity for the Electrochemical Oxidation of Methanol
Authors: Yin Zhen , Zhou Wu , Gao Yongjun , Ma Ding , Kiely Christopher J. , Bao Xinhe 
Published: March 2012

AbstractMonodisperse bimetallic Pd–Cu nanoparticles with controllable size and composition were synthesized by a one‐step multiphase ethylene glycol (EG) method. Adjusting the stoichiometric ratio of the Pd and Cu precursors afforded nanoparticles with different compositions, such as Pd85–Cu15, Pd56–Cu44, and Pd39–Cu61. The nanoparticles were separated from the solution mixture by extraction with non‐polar solvents, such as n‐hexane. Monodisperse bimetallic Pd–Cu nanoparticles with narrow size‐distribution were obtained without the need for a size‐selection process. Capping ligands that were bound to the surface of the particles were removed through heat treatment when the as‐prepared nanoparticles were loaded onto a Vulcan XC‐72 carbon support. Supported bimetallic Pd–Cu nanoparticles showed enhanced electrocatalytic activity towards methanol oxidation compared with supported Pd nanoparticles that were fabricated according to the same EG method. For a bimetallic Pd–Cu catalyst that contained 15 % Cu, the activity was even comparable to the state‐of‐the‐art commercially available Pt/C catalysts. A STEM‐HAADF study indicated that the formation of random solid‐solution alloy structures in the bimetallic Pd85–Cu15/C catalysts played a key role in improving the electrochemical activity.
On Oxygen‐Containing Groups in Chemically Modified Graphenes
Authors: Bonanni Alessandra , Ambrosi Adriano , Pumera Martin 
Published: March 2012

AbstractReduced graphenes (belonging to the class of chemically modified graphenes, CMG) are one of the most investigated and utilized materials in current research. Oxygen functionalities on the CMG surfaces have dramatic influences on material properties. Interestingly, these functionalities are rarely comprehensively characterized. Herein, the four most commonly used CMGs, mainly electrochemically reduced graphene oxide (ER‐GO), thermally reduced graphene oxide (TR‐GO), and the corresponding starting materials, that is, graphene oxide and graphite oxide, were comprehensively characterized by a wide variety of methods, such as high‐resolution X‐ray photoelectron spectroscopy, electrochemical impedance spectroscopy, UV/Vis spectroscopy, transmission electron microscopy (TEM), and voltammetry, to establish connections between the structures of these materials that carry different oxygen functionalities and their electrochemical behaviors. This was followed by the quantification of the negatively charged oxygen‐containing groups (OCGs) by UV/Vis spectroscopy and of the electrochemically reducible OCGs by voltammetry. Lastly, a biofunctionalization with gold nanoparticle (AuNP)‐modified DNA sequences was performed by the formation of covalent bonds with the carboxylic groups (COOH) on the CMG surfaces. There was an evident predominance of functionalizable COOH groups on the ER‐GO surface, as confirmed by a higher amount of Au detected both with differential‐pulse voltammetry and impedance spectroscopy, coupled with visualization by TEM. We exploited the DNA–Au bioconjugates as highly specific stains to localize and visualize the positions of carboxylic groups. Our findings are very important to clearly identify the presence, nature, and distribution of oxygen functionalities on different chemically modified graphenes.
ChemInform Abstract: Ba6P12N17O9Br3 — A Column‐Type Phosphate Structure Solved from Single‐Nanocrystal Data Obtained by Automated Electron Diffraction Tomography.
Authors: Mugnaioli Enrico , Sedlmaier Stefan J. , Oeckler Oliver , Kolb Ute , Schnick Wolfgang 
Published: March 2012

AbstractThe new title compound is obtained as main product from a mixture of BaBr2, BaS, PS(NH2)3, and PO(NH2)3 (silica glass ampule, 750 °C, 48 h).
ChemInform Abstract: Structural Studies of Magnesium Nitride Fluorides by Powder Neutron Diffraction.
Authors: Brogan Michael A. , Hughes Robert W. , Smith Ronald I. , Gregory Duncan H. 
Published: March 2012

AbstractMgNF3 and Mg2NF are synthesized by solid state reaction of stoichiometric mixtures of Mg3N2 and MgF2 (flowing Ar, 1323—1423 K, 5 d).
ChemInform Abstract: Unprecedented Bidentate Coordination of the Uranyl Cation by the Chromate Anion in the Structure of [(CH3)2CHNH3]2 [UO2(CrO4)2].
Authors: Siidra Oleg I. , Nazarchuk Evgeny V. , Krivovichev Sergey V. 
Published: March 2012

AbstractOrange‐yellow crystals of the title compound are hydrothermally prepared from a mixture of CrO3, UO2(NO3)2, iPrNH2, and H2O (autoclave, 100 °C, 6 d).
ChemInform Abstract: Facile Regio‐ and Stereoselective Hydrometalation of Alkynes with a Combination of Carboxylic Acids and Group 10 Transition Metal Complexes: Selective Hydrogenation of Alkynes with Formic Acid.
Authors: Shen Ruwei , Chen Tieqiao , Zhao Yalei , Qiu Renhua , Zhou Yongbo , Yin Shuangfeng , Wang Xiangbo , Goto Midori , Han Li‐Biao 
Published: March 2012

AbstractThe catalytic hydrogenation of alkynes such as (I) with formic acid can be controlled by changing the conditions to selectively produce (Z)‐alkenes such as (II), (E)‐alkenes such as (III), or alkanes such as (IV).
ChemInform Abstract: Aryl—Aryl Bond Formation by the Fluoride‐Free Cross‐Coupling of Aryldisiloxanes with Aryl Bromides.
Authors: Spring David R. , et al. et al. 
Published: March 2012

AbstractThe procedure described herein offers a novel, cost‐effective, fluoride‐free, operationally simple and robust alternative for the preparation of a wide range of substituted biaryl systems.
ChemInform Abstract: Well‐Defined Cyclopentadienyl NHC Iron Complex as the Catalyst for Efficient Hydrosilylation of Amides to Amines and Nitriles.
Authors: Bezier David , Venkanna Gopaladasu T. , Sortais Jean‐Baptiste , Darcel Christophe 
Published: March 2012

AbstractA variety of secondary and tertiary aromatic and aliphatic amides is successfully reduced to the corresponding amines, e.g. (II), (IV), (VI) and (VIII), by visible light‐induced Fe—NHC‐catalyzed hydrosilylation reaction.
ChemInform Abstract: Tandem Reaction of 1,2‐Allenic Ketone with α‐Halo Ketone or α‐Halo Ester in Water: An Efficient and Sustainable Synthesis of 1,3,4′‐Tricarbonyl Compounds.
Authors: Fan Xuesen , He Yan , Cui Liangyan , Zhang Xinying , Wang Jianji 
Published: March 2012

AbstractIt is further noticed that with 1,4‐diaryl‐buta‐2,3‐dien‐1‐ones, e.g. (IV), 2‐allenyl‐1,4‐diketones (V) rather than their 1,3,4′‐tricarbonyl counterparts are obtained.
ChemInform Abstract: Cationic Palladium Complex Catalyzed Diastereoselective Tandem Annulation of 2‐Iminoarylboronic Acids with Substituted Alkynes: Enantioselective Synthesis of Aminoindene Derivatives by Double Asymmetric Induction.
Authors: Yu Xufen , Lu Xiyan 
Published: March 2012

AbstractA new and efficient method to prepare chiral and achiral aminoindenes is reported.
ChemInform Abstract: Pd(0)‐Catalyzed Oxy‐ and Aminoalkynylation of Olefins for the Synthesis of Tetrahydrofurans and Pyrrolidines.
Authors: Nicolai Stefano , Waser Jerome 
Published: March 2012

AbstractThe first Pd‐catalyzed intramolecular oxy‐ and aminoalkynylation of nonactivated olefins is reported.
ChemInform Abstract: A Dual‐Catalysis Approach to the Asymmetric Steglich Rearrangement and Catalytic Enantioselective Addition of O‐Acylated Azlactones to Isoquinolines.
Authors: De Chandra Kanta , Mittal Nisha , Seidel Daniel 
Published: March 2012

AbstractO‐acylated azlactones (I) can be efficiently rearranged to the corresponding C‐acylated products (II) by using the combination of a chiral hydrogen‐bonding catalyst and a simple nucleophilic catalyst.
ChemInform Abstract: The Solvent‐Free and Catalyst‐Free Conversion of an Aziridine to an Oxazolidinone Using Only Carbon Dioxide.
Authors: Phung Chau , Ulrich Rani M. , Ibrahim Mostafa , Tighe Nathaniel T. G. , Lieberman Deborah L. , Pinhas Allan R. 
Published: March 2012

AbstractThe conversion of unactivated 2‐alkyl or 2‐aryl aziridines (I) and (IV) with CO2 (II) generates the corresponding oxazolidones (III) and (V) without the need of catalysis or solvent in high yields, especially when using high speed ball milling.
ChemInform Abstract: A Facile Synthetic Route for the Preparation of 4‐Substituted 6‐Methyl‐2‐pyrone Derivatives via Organozinc Reagents.
Authors: Rieke Reuben D. , Kim Seung‐Hoi 
Published: March 2012

AbstractTwo different approaches are presented, the first includes the novel organozinc reagent (I) for Pd‐ or Cu‐catalyzed reactions with acid chlorides, heteroaryl bromides, or aryl iodides.
ChemInform Abstract: Tin‐Free Radical Reactions under Minimal Solvent Conditions for the Synthesis of Substituted Chromones and Coumarins.
Authors: Zimmerman Jake R. , Manpadi Madhuri , Spatney Russell 
Published: March 2012

AbstractThe radical addition of alkyl iodides (II) to chromone (I) proceeds readily in the presence of triethylborane as both a radical initiator and a chain transfer agent.
ChemInform Abstract: Synthesis of a New Class of β‐Iodo N‐Alkenyl 2‐Pyridones.
Authors: Tasker Sarah Z. , Brandsen Benjamin M. , Ryu Keun Ah , Snapper Gregory S. , Staples Richard J. , DeKock Roger L. , Anderson Carolyn E. 
Published: March 2012

AbstractA new method for the synthesis of title compounds (II) from 2‐propargyloxypyridines (I) is described and a mechanism for the transformation is suggested.
ChemInform Abstract: Highly Efficient Synthesis of Quinoxalinone‐N‐oxide via Tandem Nitrosation/Aerobic Oxidative C—N Bond Formation.
Authors: Kobayashi Yusuke , Kuroda Mami , Toba Natsuki , Okada Mari , Tanaka Rie , Kimachi Tetsutaro 
Published: March 2012

AbstractAn new method for the preparation of quinoxalinone‐N‐oxides (II) from cyanoacetanilides (I) via a tandem reaction sequence is developed.
ChemInform Abstract: A New Way for Synthesis of Phenoxazine and Diphenoxazine Derivatives via Electrochemical Method.
Authors: Davarani Saied Saeed Hosseiny , Bojdi Majid Kalate , Mehdinia Ali 
Published: March 2012

AbstractThe electrochemical oxidation of hydroquinones (I) and (VI) in the presence of phenols (II) and (IV) as nucleophiles is studied.
ChemInform Abstract: Synthesis of Azepino[1,2‐a]benzimidazoles and Imidazo[1,2‐a]azepines
Authors: Potikha L. M. , Turelyk A. R. , Kovtunenko V. A. 
Published: March 2012

Abstractvia reactions of benzimidazole or imidazoles with γ‐bromodypnones
ChemInform Abstract: Synthesis and Biological Activity of Alkylidene‐Substituted Cephems and Penams.
Authors: Potorocina I. , Vorona M. , Shestakova I. , Domracheva I. , Liepinsh E. , Veinberg G. 
Published: March 2012

AbstractNew tert‐butyl esters of cephalosporin and penicillin analogs with an alkylidene substituent in the β‐lactam ring are synthesized.
ChemInform Abstract: Potential of Nanocarbons and Related Substances as Adsorbents and Chemical Storage Materials for H2, CO2 and Other Gases
Authors: Rao C. N. R. , Maitra Urmimala , Subrahmanyam K. S. , Gopalakrishnan K. , Kumar Nitesh , Kumar Ram , Govindaraj A. 
Published: March 2012

AbstractReview: 120 refs.
ChemInform Abstract: Cobalt‐Catalyzed Coupling of Alkyl Iodides with Alkenes: Deprotonation of Hydridocobalt Enables Turnover.
Authors: Weiss Matthias E. , Kreis Lukas M. , Lauber Alex , Carreira Erick M. 
Published: March 2012

AbstractA novel method using cobalt catalysts (I) and irradiation with blue LEDs allows the intramolecular Heck‐type coupling yield the corresponding cyclic products under mild conditions.
ChemInform Abstract: Synthesis of Chiral Sulfoximines Derived from 3‐Aminoquinazolinones and Their Catalysis of Enantioselective Diethylzinc Addition to Aldehydes.
Authors: Karabuga Semistan , Cakici Murat , Kazaz Cavit , Sahin Ertan , Kilic Hamdullah , Ulukanli Sabri 
Published: March 2012

AbstractThe sulfoximine QAS, which can be easily prepared in 5 steps in a 41% overall yield, shows the best results in the title reaction [cf.
ChemInform Abstract: A Sustainable Byproduct‐Catalyzed Domino Strategy: Facile Synthesis of α‐Formyloxy and Acetoxy Ketones via Iodination/Nucleophilic Substitution/Hydrolyzation/Oxidation Sequences.
Authors: Zhu Yan‐Ping , Gao Qing‐He , Lian Mi , Yuan Jing‐Jing , Liu Mei‐Cai , Zhao Qin , Yang Yan , Wu An‐Xin 
Published: March 2012

Abstractα‐Formyloxy and acetoxy ketones (III) and (V) are prepared from aromatic and unsaturated methyl ketones (I).
ChemInform Abstract: Palladium‐Catalyzed Aromatic Sulfonylation: A New Catalytic Domino Process Exploiting in situ Generated Sulfinate Anions.
Authors: Le Duc Gaetan , Bernoud Elise , Prestat Guillaume , Cacchi Sandro , Fabrizi Giancarlo , Iazzetti Antonia , Madec David , Poli Giovanni 
Published: March 2012

AbstractPd‐catalyzed generation of sulfinate anions and subsequent reaction with aryl iodides gives sulfones in varying yields.
ChemInform Abstract: Synthesis of Diaryl Ketones via a Phosphine‐Free Fukuyama Reaction.
Authors: Kunchithapatham Kamala , Eichman Chad C. , Stambuli James P. 
Published: March 2012

AbstractSignificant improvements in the diaryl ketone synthesis via the Fukuyama reaction are achieved by employing Pd(dba)2 without an external ligand.
ChemInform Abstract: Metal‐Free Synthesis of 3‐Chalcogen Benzo[b]furans via an Iodine‐Mediated Electrophilic Cyclization of 2‐Alkynylanisoles.
Authors: Xu Mei , Zhang Xiao‐Hong , Zhong Ping 
Published: March 2012

AbstractThe convenient protocol is applied to various aliphatic and aromatic disulfides and some diselenides.
ChemInform Abstract: Regioselective and Stereoselective Cyclizations of Cyclohexadienones Tethered to Active Methylene Groups.
Authors: Tello‐Aburto Rodolfo , Kalstabakken Kyle A. , Volp Kelly A. , Harned Andrew M. 
Published: March 2012

AbstractThe regio‐ and stereoselectivity is primarily influenced by electronic effects.
ChemInform Abstract: Synthesis of Benzothiophene Derivatives from Dilithio Reagents, Sulfur, and Electrophiles via Electrophilic Cyclization.
Authors: Wang Zitao , Geng Weizhi , Wang Hanliu , Zhang Shaoguang , Zhang Wen‐Xiong , Xi Zhenfeng 
Published: March 2012

AbstractTwofold lithiation of o‐bromoethynylbenzenes (I) followed by addition of 0.25 equiv.
ChemInform Abstract: [(S)‐BINAP]PdBr2‐Catalyzed Direct Synthesis of 2,3‐Disubstituted Indoles via a Tandem Reaction Between Arylamines and α‐Diketones.
Authors: Cabrera A. , Sharma P. , Ayala M. , Rubio‐Perez L. , Amezquita‐Valencia Manuel 
Published: March 2012

AbstractInterestingly, unsymmetrical 1,2‐diones react highly regioselectively with the bulkier substituent at the 2‐position of the resulting indole.
ChemInform Abstract: Solvent‐Free, Microwave Assisted Knoevenagel Condensation of Novel 2,5‐Disubstituted Indole Analogues and Their Biological Evaluation.
Authors: Biradar J. S. , Sasidhar B. S. 
Published: March 2012

AbstractSynthesis of Knoevenagel condensation products (III), (V), (VII) and screening for their cytotoxic and antioxidant activities are described.
ChemInform Abstract: Synthesis and Antileishmanial Evaluation of 1‐Aryl‐4‐(4,5‐dihydro‐1H‐imidazol‐2‐yl)‐1H‐pyrazole Derivatives.
Authors: dos Santos Mauricio S. , Oliveira Mariana L. V. , Bernardino Alice M. R. , de Leo Rosa M. , Amaral Veronica F. , de Carvalho Flavia T. , Leon Leonor L. , Canto‐Cavalheiro Marilene M. 
Published: March 2012

AbstractA series of title compounds of type (I) (14 examples) is prepared and tested in vitro against three Leishmania species.
ChemInform Abstract: Synthesis of Unsymmetrical Polysubstituted Pyridines from β‐Sulfonylvinylamines via 1‐Aza‐Allyl Anion Intermediates.
Authors: Lau Chan , Tsui Gavin Chit , Lautens Mark 
Published: March 2012

AbstractA modular synthesis of 2,4,6‐trisubstituted pyridines is developed using the base‐promoted cyclocondensation of (Z)‐β‐sulfonylvinylamines with chalcone‐type α,β‐unsaturated ketones.
ChemInform Abstract: Synthesis of N‐(3‐Cyano‐7‐ethoxy‐1,4‐dihydro‐4‐oxoquinolin‐6‐yl)acetamide.
Authors: Zhang Qiang , Mao Yongjun , Liu Zheng , Xie Kai , Zhu Yi , Wei Yabing , Jiang Xiangrui , Shen Jingshan 
Published: March 2012

AbstractCompound (VIII) (overall yield: 31% over 10 steps) is an important key intermediate for the synthesis of EKB‐569 or neratinib which are dual irreversible inhibitors of the epitermal growth factor receptor.
ChemInform Abstract: Synthesis and Biological Assessment of Diversely Substituted Furo[2,3‐b]quinolin‐4‐amine and Pyrrolo[2,3‐b]quinolin‐4‐amine Derivatives, as Novel Tacrine Analogues.
Authors: Carreiras M. Carmo , et al. et al. 
Published: March 2012

AbstractTitle compounds (III) are obtained by a Friedlaender‐type reaction using excess cycloalkanone (2 to 4 equiv.).
ChemInform Abstract: Facile Synthesis of New 4‐Aza‐podophyllotoxin Analogues via Microwave‐Assisted Multi‐Component Reactions and Evaluation of Their Cytotoxic Activity.
Authors: Shi Feng , Zeng Xiao‐Ning , Zhang Ge , Ma Ning , Jiang Bo , Tu Shujiang 
Published: March 2012

AbstractA simple, atom‐economical, and environmentally friendly synthesis of the title compounds (IV) is presented.