bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute Posttraumatic Catastrophic Failure of a Second-generation, Highly Cross-linked Ultra-high-molecular-weight Polyethylene Patellar Component
Authors: Goldstein Matthew J. , Ast Michael P. , DiMaio Frank R. 
Published: July 2012

A 74-year-old man underwent total knee arthroplasty in 1996 and subsequent revision total knee arthroplasty for aseptic loosening in 2005. During revision, an all-polyethylene, 7-mm, second-generation, highly cross-linked ultra-high-molecular-weight polyethylene patellar component (Durasul; Zimmer, Warsaw, Indiana) was used. The patient recovered well, but he presented with severe acute pain after a popping feeling was detected during a game of golf in postoperative year 4. Radiographs demonstrated a fracture of the patellar component. At re-revision surgery, polyethylene fragments were encountered without visual evidence of wear. Appropriate rotational and axial alignment of the components was confirmed. Patellar revision was performed.
To the authors’ knowledge, this is the first report of an acute posttraumatic catastrophic fracture of a second-generation, highly cross-linked ultra-high-molecular-weight polyethylene patellar component. Although no malposition of the components was noted, abnormal tensile forces across the patellar component can be transmitted by altered patellofemoral kinematics. This combination could lead to a small surface crack that propagates deeper into the component with continued impaction and an eventual acute fracture of the entire component. The patellar component failed in a piecemeal fashion following acute trauma. Although many advantages exist to the enhancement of polyethylene patellar components, including the potential for improved wear characteristics, cross-linking has reduced resistance to crack initiation and propagation. Therefore, fracture risk should be considered when using second-generation, highly cross-linked ultra-high-molecular-weight polyethylene.
Penetrating Injury of the Spinal Cord Treated Surgically
Authors: Wang Zhenyu , Liu Yi , Qu Zhigang , Leng Jiali , Fu Changfeng , Liu Guomin 
Published: July 2012

A 44-year-old man reported acute neck pain, hyperalgesia, and mild paraplegia caused by a wire-penetrating injury of the neck and was hospitalized. The foreign body was located at the C6 level. Pre- and postoperative physical examination and imaging studies were performed to assess the degree of injury. Emergent surgery was performed 30 minutes after admission to prevent the patient from potential severe neurological impairment and infection.
The patient’s postoperative recovery was significant. Only hyperalgesia at the ulnar side of the forearm remained, with no other positive signs of neurologic loss. Motor strength of the upper and lower extremities returned to normal. The postoperative degree of the spinal cord injury was assessed as American Spinal Injury Association grade E.
Surgical removal of foreign bodies retained in the spinal canal may prevent infection, myelopathy, and delayed neurologic loss. Removal of retained intraspinal metallic fragments can improve neurologic outcome.
Effect of Autoclave Postpolymerization Treatments on the Fracture Toughness of Autopolymerizing Dental Acrylic Resins
Authors: Durkan Rukiye , Gürbüz Ayhan , Yilmaz Burak , Özel M. Birol , Bağιş Bora 
Published: July 2012

Introduction Microwave and water bath postpolymerization have been suggested as methods to improve the mechanical properties of heat and autopolymerizing acrylic resins. However, the effects of autoclave heating on the fracture properties of autopolymerizing acrylic resins have not been investigated. Purpose The aim of this study was to assess the effectiveness of various autoclave postpolymerization methods on the fracture properties of 3 different autopolymerizing acrylic resins. Methods Forty-two specimens of 3 different autopolymerizing acrylic resins (Orthocryl, Paladent RR and Futurajet) were fabricated (40×8×4mm), and each group was further divided into 6 subgroups (n=7). Control group specimens remained as processed (Group 1). The first test group was postpolymerized in a cassette autoclave at 135°C for 6 minutes and the other groups were postpolymerized in a conventional autoclave at 130°C using different time settings (5, 10, 20 or 30 minutes). Fracture toughness was then measured with a three-point bending test. Data were analyzed by ANOVA followed by the Duncan test (α=0.05). Results The fracture toughness of Orthocryl and Paladent-RR acrylic resins significantly increased following conventional autoclave postpolymerization at 130°C for 10 minutes (P<.05). However, the fracture toughness of autoclave postpolymerized Futurajet was not significantly different than its control specimens (P<.05). The fracture toughness of Futurajet was significantly less than Paladent RR and Orthocryl specimens when autoclaved at 130°C for 10 minutes. Conclusions Within the limitations of this study, it can be suggested that autoclave postpolymerization is an effective method for increasing the fracture toughness of tested autoploymerized acrylic resins.
L’évaluation de la performance des collèges publics québécois par la méthode du Data Envelopment Analysis
Authors: Broussau Frédéric , Ouellette Pierre , Vierstraete Valérie 
Published: July 2012

Le système collégial public québécois est très dépendant financièrement des subventions accordées par le gouvernement provincial. En effet, 85 % des revenus des collèges d’enseignement général et professionnel (cégeps) proviennent de subventions gouvernementales. Les cégeps se plaignent d’un sous-financement chronique depuis les fortes coupures budgétaires qu’a connu le système d’enseignement québécois pendant les années quatre-vingt-dix. Avant d’appuyer ce discours, il faut vérifier si les cégeps prouvent leur efficience dans la gestion des fonds publics. C’est cette mesure d’efficience des cégeps que nous faisons dans cette étude.Nous évaluons l’efficience des cégeps à l’aide de la méthode duData Envelopment Analysis(DEA) à partir d’une banque de données originale fournie par le ministère de l’Éducation, du Loisir et du Sport du Québec. Nous calculons ainsi une efficience relative, en comparant les cégeps les uns aux autres. Notre étude établit que les cégeps sont, en moyenne, efficients à 90 %. Ceci représente des économies potentielles d’environ 140 millions de dollars, soit 10 % des dépenses totales des cégeps. Nous montrons également que l’efficience des cégeps a varié dans le temps et est inversement liée aux subventions budgétaires, l’efficience ayant augmenté lors des coupures budgétaires.
Le gradient santé / revenu familial des nouveau-nés québécois de 1998 après quatre ans : faible ou inexistant?
Authors: Lefebvre Pierre 
Published: July 2012

La relation (le « gradient ») entre l’indice de santé des adultes et leur statut socio-économique (SSE) - mesuré notamment par le revenu, l’éducation et l’emploi – est un des constats les plus robustes des recherches en santé. Dans une étude marquante appuyée sur des données américaines, Case et alii (2002) montrent que la santé des jeunes enfants est non seulement liée positivement avec le revenu familial mais que la relation est plus prononcée avec l’âge. Ce travail analyse la relation entre le revenu familial et les états de santé d’un échantillon représentatif d’environ 2 000 nouveau-nés du Québec, suivis annuellement depuis l’âge de 5 mois (en 1998) jusqu’à l’âge d’environ 50 mois (en 2002). Les résultats pour chacun des cinq cycles de l’enquête indiquent la présence d’un lien positif mais très faible entre le niveau de santé des enfants et le revenu familial. La relation est instable dans le temps et semble jouer seulement au-delà de certains seuils de revenu. Cependant, les problèmes de santé chroniques ont un effet important sur l’indice de santé des enfants que le revenu familial parvient mal à contrer. À l’égard du gradient de santé des enfants et ses répercussions, les résultats suggèrent que tout se joue plutôt après cinq ans.
Sur le nombre optimal d’organismes de bienfaisance
Authors: Barla Philippe , Pestieau Pierre 
Published: July 2012

Dans cet article, nous supposons que contribuer à un organisme de bienfaisance (OB) procure du « plaisir de donner » (ou un « effet d’aura ») uniquement si les valeurs idéologiques de l’organisme sont proches de celle du donateur. Nous supposons également que la création d’un nouvel OB génère un coût d’entrée. Ainsi, si un plus grand nombre d’OB conduit à plus de dons, cela entraîne également une réplication des coûts fixes. Nous comparons le nombre d’OB dans une situation de « laissez-faire » avec le nombre optimal à l’équilibre de premier rang. Nous examinons ensuite la solution de second rang lorsque le seul instrument de politique publique est le nombre d’OB.
De la transmission de la volatilité à la contagion entre marchés boursiers : l’éclairage d’un modèle VAR non linéaire avec bris structurels en variance
Authors: Bensafta Kamel Malik , Semedo Gervasio 
Published: July 2012

Nous développons dans cet article une modélisation vectorielle autorégressive non linéaire pour l’étude des interdépendances entre les marchés boursiers. Parmi les innovations de ce travail, nous introduisons un bris structurel dans la matrice des variances-covariances conditionnelle d’un processus GARCH multivarié. Dans cet ordre d’idée, nous considérons une spécification BEKK de cette matrice augmentée avec des régresseurs de transmission des chocs de volatilité entre les marchés. L’objectif de cette modification est de répondre à plusieurs biais importants dans la mesure des volatilités et des corrélations entre les marchés : d’une part, le biais de surestimation de la persistance des chocs de volatilité; d’autre part, les biais d’hétéroscédasticité et de variables omises dans la mesure des corrélations. Nous considérons ici un échantillon de 11 marchés boursiers d’Europe, d’Amérique du Nord et d’Asie avec des données hebdomadaires des indices les plus larges entre 1985 et 2006. Plusieurs résultats intéressants sont obtenus avec cette modélisation : la réduction de la persistance des chocs de volatilité; l’évidence d’une transmission des prix et des incertitudes du marché américain vers les marchés européens et asiatiques; l’existence de phénomène de transmission régionale en Europe et en Asie; mis à part le krach américain d’octobre 1987, toutes les crises ne sont pas systématiquement contagieuses. Au final, il n’est pas évident que la libéralisation financière isole les marchés des crises financières diverses, bien que l’intégration soit un vecteur d’efficience des marchés. Les crises et le phénomène de contagion en période de crise peuvent être considérés comme des processus de rééquilibrage des marchés qui doivent être encadrés, régulés et supervisés.
Postrecurrence Treatment in Neoadjuvant or Adjuvant FDA Registration Trials
Authors: Olivier Timothée , Haslam Alyson , Prasad Vinay 
Published: June 2024

ImportanceIn oncology randomized clinical trials, suboptimal access to best available care at recurrence (or relapse) may affect overall survival results.ObjectiveTo assess the proportion and the quality of postrecurrence treatment received by patients enrolled in US Food and Drug Administration (FDA) registration trials of systemic therapy in the adjuvant or neoadjuvant setting.Evidence ReviewFor this systematic review, all trials leading to an FDA approval from January 2018 through May 2023 were obtained from the FDA website and drug announcements. Randomized clinical trials of an anticancer drug in the neoadjuvant or the adjuvant setting were included. Trials of supportive care treatment and treatments given in combination with radiotherapy were excluded. Information abstracted for each trial included tumor type, setting, phase, type of sponsor, reporting and assessment of postrecurrence, and overall survival data.FindingsA total of 14 FDA trials met the inclusion criteria. Postrecurrence data were not available in 6 of 14 registration trials (43%). Of the 8 remaining trials, postrecurrence treatment was assessed as suboptimal in 6 (75%). Overall, only 2 of 14 trials (14%) had data assessed as appropriate.Conclusions and RelevanceThis systematic review found that 43% of randomized clinical trials of anticancer treatment in the adjuvant or neoadjuvant context failed to present any assessable postrecurrence treatment data. In instances in which these data were shared, postrecurrence treatment was suboptimal 75% of the time. The findings suggest that regulatory bodies should enforce rules stipulating that patients have access to the best standard of care at recurrence.
Manipulating Molecular Stacking to Achieve High Electron Mobility in 2D Conjugated Ultra‐Narrow Bandgap Non‐Fullerene Acceptors with Absorption Beyond 1000 nm
Authors: Liao Xunfan , Liu Mingtao , Xie Wenchao , Wang Junwei , Zhu Peipei , Yu Shicheng , Fu Yuang , Lu Xinhui , Feng Kui , Guo Xugang , Chen Yiwang 
Published: June 2024

AbstractN‐type organic semiconductors are essential for the advancement of organic electronic devices. However, in relation to extensive research on n‐type and p‐type polymers, studies on high‐mobility n‐type small‐molecule semiconductors (SMSCs) are limited. Here, a series of ultra‐narrow bandgap n‐type SMSCs are developed on an A‐D‐A‐type structure. These SMSCs feature an exceptionally large π‐conjugated area, leading to strong intramolecular charge transfer and robust π‐π interactions. For the first time, central core and terminal halogenation are employed to control molecular surface electrostatic potential distribution, thereby regulating the π‐π stacking area (Sπ‐π) and studying their correlation. The research reveals that, in n‐type SMSCs with an edge‐on arrangement, introducing fluorine into the 2D central core can reduce the Sπ‐π, which is detrimental to the electron mobility (µe) of organic field‐effect transistors (OFETs). Conversely, terminal chlorination facilitates electron injection and improves µe. Consequently, DTPC‐OD‐4Cl, featuring shorter alkyl side chains and a non‐fluorinated 2D central core and undergoing terminal chlorination, achieved the highest µe of up to 0.52 cm2 V−1 s−1, ranking among the highest values reported for A‐D‐A type SMSCs. This work not only systematically investigated the influence of molecular structure on mobility but also provided novel insights for designing more efficient n‐type SMSCs.
Extreme Hydrogel Bioelectronics
Authors: He Xuecheng , Liu Dingyao , Cui Binbin , Huang Hao , Dai Shilei , Pang Ivo , Qiao Yuchun , Xu Tailin , Zhang Shiming 
Published: June 2024

AbstractThe last decades have witnessed the rapid growth of hydrogel bioelectronics. Traditional hydrogels face challenges when working under extreme conditions, causing a loss of stabilities and functionalities. This review provides a systematic overview of hydrogels capable of working under extreme conditions, with a focus on their applications in bioelectronic systems. These hydrogels are summarized into categories of anti‐mechanical damage, anti‐detachment, anti‐swelling, anti‐freezing, and anti‐foreign body response. Strategies including material development and structural design that can endow hydrogels with the above extreme properties are introduced. Finally, current challenges and new opportunities in developing extreme hydrogel bioelectronic devices and systems are discussed.
Freezing, Salting‐Out and Mineralization — A Simple, Universal and Modular Strategy for Constructing Mineralized Hydrogels
Authors: Xu Liupan , Kang Haifei , Wei Wenying , Goto Takashi , Wu Xiaopei , Dai Honglian 
Published: June 2024

AbstractMineralized hydrogels have attracted significant attention in the field of bone repair. Herein, an innovative strategy of “freezing, salting‐out and mineralizing” (FSM) is proposed for the construction of mineralized hydrogels. Based on this strategy, a collagen/hydroxyapatite (HA) mineralized hydrogel is synthesized as the template of mineralized hydrogels, and the critical roles of freezing and salting‐out in the formation of hydrogels are demonstrated. Comparative analyses with collagen/HA mineralized hydrogels synthesized through two other traditional methods reveal that the hydrogel constructed by FSM exhibits satisfactory operation simplicity, mineralization degree, uniformity distribution, mechanical property, degradation stability, cytocompatibility, and osteogenic property, indicating that it can serve as an ideal mineralized hydrogel scaffold for bone repair. Furthermore, 16 other kinds of mineralized hydrogels with different systems are constructed by modularly expanding the raw materials used in the FSM process to nine common biomedical polymers, four metal cations and three anions, confirming the universality of the proposed FSM strategy for most mineralized hydrogel. Overall, the three‐step FSM strategy, which integrates the salting‐out effect with mineralization, represents a groundbreaking approach for the fabrication of mineralized hydrogels, offering a simple, universal and modular method for their construction.
First Structured Uranium‐Based Monoliths Produced via Vat Photopolymerization for Nuclear Applications
Authors: Zanini Alice , Celdran Pedro Amador , Walter Olaf , Carturan Sara Maria , Boshoven Jacobus , Bulgheroni Antonio , Biasetto Lisa , Manzolaro Mattia , Eloirdi Rachel , Corradetti Stefano , Franchin Giorgia 
Published: June 2024

AbstractUranium plays an unquestionable role in the framework of nuclear physics, biology, and radiopharmacy. Moreover, uranyl ion UO22+ offers an immense variety of applications due to the unique photosensitivity of its complexes. The excited state of uranyl cation is indeed accessible under ultraviolet‐visible (UV–vis) light, readily producing radical species UO22+* upon light irradiation. Herein, an innovative synthesis protocol is presented to explore the use of uranyl cations as photocatalyst systems for photocurable sol–gel‐based formulations, coupling the photochemical reactions of uranyl cations with photopolymerization‐based additive manufacturing processes. Additive manufacturing has nowadays revolutionized the production of complex structures with arbitrary geometries and has opened up enticing opportunities for innovative technological breakthroughs and highly tailorable systems. The fabrication of micro‐architected components is shown via vat photopolymerization, namely, the Digital Light Processing technique, and ‐3D) printed parts are converted into uranium dicarbide (UC2)/carbon nanocomposite upon carbothermal reduction. This uranyl‐mediated additive manufacturing process constitutes the first application of the synergistic role of uranyl motifs in a photopolymer platform, demonstrating for the first time the possibility to directly pattern uranium‐based materials in complex structures.
Persistent Room‐Temperature Phosphorescent Organohydrogels Based on Nonaromatic Luminogens Crosslinked by Hydrogen Bonds
Authors: Deng Junwen , Liu Deyu , Liu Haiqi , Yu Linxuan , Bai Yunhao , Xiao Jinsheng , Wang Huiliang 
Published: June 2024

AbstractThe development of persistent room‐temperature phosphorescent (pRTP) hydrogels is important for the practical applications of organic phosphors. Unfortunately, the phosphorescence emission of nontraditional luminogens (NTLs) can be strongly quenched by water in hydrogel networks. Herein, a series of pRTP organohydrogels based on NTLs are prepared by dissolving poly(vinyl alcohol) (PVA), biuret (BIU) and poly(maleic acid) (PMAc) (or other nonaromatic macromolecular acids) in a glycerol/water mixed solvent, followed by a simple freezing‐thawing treatment. Very impressively, the organohydrogel exhibits remarkable excitation‐dependent and metal cation‐responsive phosphorescence with a maximum lifetime up to 782.8 ms at ambient conditions. Moreover, the organohydrogels treated with metal cations also have excitation‐dependent phosphorescence. Multidimensional information encryption can be achieved by simply printing solutions of metal cations onto the gel surface and switching the irradiation lights, or using gel blocks prepared with different macromolecular acids. Structural characterizations, mechanical tests, and comparative studies prove that hydrogen bonding between BIU and macromolecular chains leads to rigidification of molecular conformations and the cooperative effect of the components leads to the pRTP of the organohydrogels. This work provides a reliable strategy for the preparation of nonaromatic phosphorescent hydrogels with long afterglows and greatly expands the practical applications of phosphorescent materials.
Heterostructure Nanozyme with Hyperthermia‐Amplified Enzyme‐Like Activity and Controlled Silver Release for Synergistic Antibacterial Therapy
Authors: Zhang Meng , Yue Wenhui , Ma Weishuai , Wang Xiaoning , Xu Yuanhong , Li Aihua 
Published: June 2024

AbstractHeterostructure nanozymes as antibiotic‐free antimicrobial agents exhibit great potential for multidrug‐resistant (MDR) bacterial strains elimination. However, realization of heterostructure antimicrobials with enhanced interfacial interaction for synergistically amplified antibacterial therapy is still a great challenge. Herein, oxygen‐vacancy‐enriched glucose modified MoOx (G‐MoOx) is exploited as a reducing agent to spontaneously reduce Ag (I) into Ag (0) that in situ grows onto the surface of G‐MoOx. The resultant Ag doped G‐MoOx (Ag/G‐MoOx) heterostructure displays augmenting photothermal effect and NIR‐enhanced oxidase‐like activity after introducing Ag nanoparticles. What's more, NIR hyperthermia accelerate Ag+ ions release from Ag nanoparticles. Introduction of Ag greatly enhances antimicrobial activities of Ag/G‐MoOx against MDR bacteria, especially the hybrid loading with 1 wt% Ag NPs exhibiting antibacterial efficacy up to 99.99% against Methicillin‐resistant Staphylococcus aureus (MRSA, 1×106 CFU mL−1).
Photoactivation of Millimeters Thick Liquid Crystal Elastomers with Broadband Visible Light Using Donor–Acceptor Stenhouse Adducts
Authors: Guillen Campos Jesus , Tobin Cassidy , Sandlass Sara , Park Minwook , Wu Yuhang , Gordon Michael , Read de Alaniz Javier 
Published: June 2024

AbstractLight‐responsive liquid crystal elastomers (LCEs) are stimuli‐responsive materials that facilitate the conversion of light energy into a mechanical response. In this work, a novel polysiloxane‐based LCE with donor–acceptor Stenhouse adduct (DASA) side‐chains is synthesized using a late‐stage functionalization strategy. It is demonstrated that this approach does not compromise the molecular alignment observed in the traditional Finkelmann method. This easy, single‐batch process provides a robust platform to access well‐aligned, light‐responsive LCE films with thickness ranging from 400 µm to a 14‐layer stack that is 5 mm thick. Upon irradiation with low‐intensity broadband visible light (100–200 mW cm−2), these systems undergo 2D planar actuation and complete bleaching. Conversely, exposure to higher‐intensity visible light induces bending followed by contraction (300 mW cm−2). These processes are repeatable over several cycles. Finally, it is demonstrated how light intensity and the resulting heat generation influences the photothermal stationary state equilibrium of DASA, thereby controlling its photoresponsive properties. This work establishes the groundwork for advancement of LCE‐based actuators beyond thin film and UV‐light reliant systems.