bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hepatitis‐B Vaccination in Pregnancy: Safety and Immunogenic Response in Mothers and Antibody Transfer to Neonates
Authors: Reddy Pranathi A. , Gupta Indu , Ganguly N.K. 
Published: August 2010

AbstractHepatitis B infection during pregnancy causes increased, maternal morbidity and perinatal mortality. No specific therapy is available, hence neonatal immuno‐prophylaxis is recommended by WHO. However, the advantages of maternal immunization are manifold. Therefore, 15 pregnant HBsAg negative women were studied after 3 dozes of hepatitis B specific vaccine. No untoward effects of vaccine were observed and a good immunogenic response with very high antibody titres 178 IU/ l and 184 IU/l at delivery and 3 months post delivery respectively were noted. Passive transfer of antibodies to the neonates was 100% at birth but these levels declined rapidly. Hence hepatitis B specific vaccine is safe and immunogenic in pregnant women and protects their babies in the immediate neonatal period.
Determinants of Birth Weight in Vietnamese Detainees in Hong Kong
Authors: Rogers M.S. , Rogers Kay 
Published: August 2010

AbstractFive hundred and fifty singleton pregnancies amongst Vietnamese Boat People delivering between January and December 1993 were studied post‐natally. Multiple regression analysis showed no direct effect of ethnic origin on birth weight. When analyses were repeated on the two main ethnic subgroups we found that, amongst Anamese patients, both gestation at delivery and birth weight independently increased with longer duration of stay in Hong Kong. This relationship was not seen in Vietnamese patients of Chinese ethnic origin. Possible reasons for these different relationships are discussed.
Macrophage Activation Factors and Cytokines in Peritoneal Fluid from Patients with Endometriosis
Authors: Ueki Minoru , Tsurunaga Takemitsu , Ushiroyama Takahisa , Ueda Masatsugu 
Published: August 2010

AbstractEndometriosis is often associated with infertility, which might be a consequence of intraperitoneal macrophage activation and various immunological events related to it. To determine what triggers macrophage activation and what immunologic conditions occur in the peritoneal cavity of a patient with endometriosis, we measured the amounts of phospholipase A2, cholesterol fractions (HDL, LDL, and VLDL), interleukins (IL)‐l and 6, granulocyte‐macrophage‐colony stimulating factor (GM‐CSF), and phosphatidylserine in peritoneal fluid. Peritoneal‐fluid samples were collected during laparoscopy or laparotomy from 14 patients with endometriosis and from 11 patients with other diseases (5 with myoma uteri, 5 with benign ovarian cysts and 1 with a double uterus) as controls. With regard to phospholipase A2, there were no significant differences between the endometriosis group and the control group. LDL was significantly lower in the endometriosis group than in the control (p < 0.05). The levels of IL‐1 and GM‐CSF were similar in both groups; IL‐6, however, was higher in 7 endometriosis patients with associated infertility than in the 9 non‐endometriosis fertile patients. These findings suggest that inflammatory tissues are not related to the activation of intraperitoneal macrophages in endometriosis patients. Cholesterol fractions (HDL or LDL) might participate in macrophage activation in these patients, but this remains to be clarified. The high IL‐6 levels observed in infertile endometriosis suggest that some immunological events that prevent patients from becoming pregnant take place in women with endometriosis‐associated infertility.
Vasospastic Action of Serotonin on the Umbilical Artery in Normal and Preeclamptic Patients
Authors: Taniguchi Katsunori 
Published: August 2010

AbstractThe purpose of this study was to determine whether elevated plasma‐free‐serototnin (5‐HT) levels in preeclampsia could evoke abnormal vasoconstriction in the umbilical artery (UmA). Threshold concentrations of 5‐HT in the UmA from 12 normal pregnant (NP) women were 5 ng/ml. Plasma‐free 5‐HT levels in the UmA (14.38 ± 5.68 ng/ml) in severe preeclampsia (SP) were higher than the threshold value. Plasma‐free 5‐HT levels in UmA blood (1.6 ± 1.2 ng/ml) in NP women were lower than the threshold value. There were significant increases in sensitivity to 5‐HT in the UmA from SP; the threshold value of 5‐HT was low (1.0 ng/ml), and the EC50 value (5.2 ± 2.4 ng/ml) was significantly lower than that of NP women (13.9 ± 3.0 ng/ml, p < 0.001). These results strongly suggest that increased plasma‐free 5‐HT and vascular hypersensitivity to 5‐HT in preeclampsia can cause vasospasms and a disturbance of the feto‐placental circulation.
Early Oral Hydration: A Novel Regimen for Management after Elective Cesarean Section
Authors: Rabbo Salah A. Abd 
Published: August 2010

AbstractObjective: To compare early oral hydration versus the conventional intravenous fluid replacement after elective cesarean section.Methods: Two hundred women performed elective cesarean section were selected and randomized to: Regimen I (n = 100): early oral hydration (sips of fruit juices sweetened with honey once the women felt thirst immediately after the operation, then solid food 24 hours later, the amounts of juice or food were determined by the patient herself, i.e. she would regulate her physiological needs) versus regimen II (n = 100): conventional intravenous hydration (2–3 L of dextrose saline/24 hours and solid food thereafter).Biochemical, metabolic values, postoperative nausea and vomiting, propulsive bowel movements, tolerance of solid food, hospital stay and successful continuation of breast feeding were compared in both groups.Results: The two regimens were equally effective in maintaining fluid balance and normal plasma and urinary electrolytes without any observed differences in biochemical or metabolic values. The return of bowel sounds, first occurrence of flatus and tolerance of solid food were achieved in regimen I at time periods significantly shorter than those attained with regimen II (p < 0.0001). The incidence of nausea and vomiting, ileus and deep vein thrombosis was higher in regimen II than in regimen I but the difference is statistically insignificant (p > 0.05). Patients in regimen II were hospitalized for significantly longer times than those on regimen I (p < 0.0001). Successful continuation of breast feeding was significantly more in regimen I than in regimen II (p < 0.01).Conclusion: Early oral hydration after elective cesarean section effectively maintained fluid balance and it was associated with rapid return of propulsive bowel movements, successful breast feeding, less side effects and shorter hospital stay than the conventional intravenous hydration. So, it should be used in most cases after elective cesarean section.
Anaphylactic Reaction to Cefazolin in Pregnancy
Authors: Konno Ryo , Nagase Satoru 
Published: August 2010

AbstractAnaphylaxis is a rare event in pregnancy, but is one that can have serious implications for both the mother and fetus. We report a case of severe anaphylactic reaction to intravenous (IV) cefazolin (CEZ) given during labor with premature rupture of membranes. Maternal shock and prolonged fetal bradycardia occurred. Both the maternal and fetal outcomes were good following treatment with ephedrine, glucocorticoids, and emergency caesarean section.
Antibodies Prevalence against HPV‐6b and ‐16 Recombinant Fusion Proteins in Korean Patients with Cervical Neoplasia*
Authors: Park Sue Nie , Yoon Hee Shick , Choi Yong Kyung , Choe In Seong , Chung Roh Pal , Chee Yong Hun , Namkoong Sung Eun , Kim Seung Jo , Park Jong Sup 
Published: August 2010

AbstractObjectives: This study was to investigate the adjunctive diagnostic utility of HPV fusion proteins from the sera in the patients with cervical neoplasia. Immunologic researches on host factors in HPV infection could contribute to better understanding of patho‐physiologic mechanisms of cervical carcinogenesis, and provide valuable informations for HPV vaccine development.Methods: Prevalence of antibodies against human papillomavirus (HPV) in sera of the patients with carcinomas (n = 81), precancers (n = 25) of uterine cervix and normal controls (n = 40) in Korean women were investigated by Western blot immunoassay using partially purified TrpE fusion recombinant proteins for HPV‐6b and HPV‐16.Results: In 81 patients with cervical cancer, 15 (19%) and 54 (67%) patients were positive for antibodies to at least one of the tested recombinant proteins related to HPV‐6b or HPV‐16, respectively. And in 25 patients with HPV‐related squamous intraepithelial lesion (SIL) of cervix, 10 were positive for at least one of the tested antibodies for HPV‐6b gene products (40%) and 11 were positive for HPV‐16 related antibodies (44%). The prevalence rates of antibodies for HPV‐6b in the sera of SIL patients were significantly higher than those from the sera of cervical cancer patients (p < 0.05). There was an inverse correlation between increasing the positivity against HPV‐16 E6 protein and progression of cervical lesions, but there was no significant correlation between the positivities of the other antibodies to HPV‐16 and the severity of disease.Conclusion: These results suggest that the recombinant proteins related to HPV‐6b and HPV‐16 could be useful in evaluation of the patients with HPV‐related cervical lesions and these might play an adjunctive role in diagnosis and management of cervical neoplasia.
Purification and Characterization of 1,25(OH)2D3 Receptor from Human Placenta
Authors: Tanamura Atsushi , Nomura Seiji , Kurauchi Osamu , Furui Toshimitsu , Mizutani Shigehiko , Tomoda Yutaka 
Published: August 2010

AbstractObjective: To characterize the receptor for 1,25‐dihydroxycholecalciferol [1,25‐(OH)2D3], we purified it from nuclear fractions of human placentae.Methods: Human placental fractions were concentrated with ammonium sulfate, extracted from hydroxylapatite, and then chromatographed on Sephacryl S‐200 and DEAE‐cellulose.Results: The receptor for [1,25‐(OH)2D3] was purified approximately 1,500‐fold. The molecular weight of the receptor was estimated to be 55 K dalton by gel filtration. The receptor fractions showed a dissociation constant (Kd) of 3.0 × 10−10 mol/l, and adsorbed to the DNA cellulose column. D3 analogs, estradiol, and progesterone had almost no effect on 1,25‐(OH)2D3 binding.Conclusion: These properties of the 1,25‐(OH)2D3 receptor in human placenta are similar to those of the chicken intestinal 1,25‐(OH)2D3 receptor.
Cytogenetic Effects of Cryopreservation on Human Sperm: Assessment Using an Improved Method for Analyzing Human Sperm Chromosomes
Authors: Okada Setsuo , Suzumori Kaoru , Yagami Yoshiaki 
Published: August 2010

AbstractObjective: To evaluate any cytogenetic effects of cryopreservation on human sperm by comparing the frequencies of sperm chromosome anomalies and sex ratios before and after freezing.Methods: Using in vitro fertilization of zona‐free hamster oocytes, analysis of sperm chromosomes was first performed on portions of fresh human semen samples. The residual semen was then analyzed for sperm chromosomes after cryopreservation for several weeks. Sperm donors were 5 healthy men aged 26–38 years.Results: A total of 166 sperm karyotypes were analyzed, 94 before freezing and 72 after freezing. The results indicated no significant differences between fresh and frozen sperm in either frequencies of aneuploidy (fresh: 0%, frozen: 2.8%) or structural anomalies (fresh: 7.5%, frozen: 9.7%). The sex ratios did not differ from the expected 1 : 1 ratio under either condition.Conclusions: The results of these studies indicate that cryopreservation does not exert any cytogenetic mutagenicity on human spermatozoa or alter X/Y ratio of human sperm.
In vitro Fertilization in a Spontaneous Cycle: A Successful Simple Protocol
Authors: Aboulghar Mohamed A. , Mansour Ragaa T. , Serour Gamal A. , Amin Yehya M. , Sattar Mehanny A. , Ramzy Abdel Megid 
Published: August 2010

AbstractObjective: To study the efficacy of a simple protocol of in vitro fertilization in the spontaneous natural cycle.Method: A prospective study using in vitro fertilization in a natural cycle for the treatment of infertility due to tubal factor.Results: Fifty‐eight patients were monitored by vaginal ultrasound and LH in urine for 229 cycles. In 49.8% of the cycles the pick‐up was canceled because of the early LH rise or failure to visualize a dominant follicle. Ovum pick‐up was performed in 112 cycles and oocyte retrieval rate was 87.5%. Embryo transfer was performed in 86 cycles, pregnancy rate per pick‐up was 10.2%, and there was no pregnancy wastage.Conclusion: IVF in a spontaneous cycle is a simple, low cost and safe treatment, which yields reasonable PR, for young regularly menstruating women with tubal factors of infertility.
A New Computer Network System for Communicating Perinatal Decision Support Information via a Telephone Line*
Authors: Kubo Takahiko , Sagara Yusuke 
Published: August 2010

AbstractObjective: For fetal monitoring and assessment of high risk mother and fetus at regional hospitals, we developed a new computer network system.Methods: The system incorporates a notebook‐type personal computer (PC‐9801nv) at regional hospital for communication in with 3 servers (IBM5580‐YOC) connected via 2 Ethernet LANs to 2 host computers (IBM3080, IBM3174) and 5 workstations (IBM5521 V2b), and transmits the compressed data by telephone. When the data arrive, the doctor in perinatal center can immediately display and interpret the data on his workstation and give appropriate advice to the doctor at the regional hospital.Results: The rate of reliable data transmission was 100%. Each 1 hour recording session and characteristic perinatal information was transmitted in less than 2 minutes. Regional medical institutions can easily access the center, and thereby can receive both simplified automatic diagnosis by fetal cardiotocography and pregnancy‐risk evaluation.Conclusions: Because this system uses telephone circuits, it can be accessed from all regions of the country. Thus, our system is useful for perinatal management of high risk mother and fetus.
Changes of Bone Mineral Density in Pregnant and Postpartum Women
Authors: Matsumoto Isamu , Kosha Shoichiro , Noguchi Shin‐ichi , Kojima Nobuko , Oki Toshimichi , Douchi Tsutomu , Nagata Yukihiro 
Published: August 2010

AbstractObjective: To explore the effects of pregnancy and postpartal lactation on bone mineral density (BMD).Methods: In this study, the BMD of 22 pregnant women in a longitudinal study, and of 75 pregnant and 111 puerperant women in a cross‐sectional study was estimated at the distal radius of the forearm by dual energy X‐ray absorptiometry. BMD was measured on 8 separate occasions from the first trimester of pregnancy to 24 months' postpartum.Results: In none of 22 pregnant women was there any noticeable change in BMD during pregnancy. Whereas no significant change in BMD occurred during the 12‐month postpartum period in 11 non‐lactating women, 11 women who breastfed had a significant decrease in BMD at 1, 3, and 6 months' postpartum, with all of them showing a further decrease in BMD at 12 months' postpartum. The BMD of the radius was significantly lower in the breast‐feeders than in the formula‐feeders at all postpartal times of evaluation except at 24 months' postpartum.Conclusion: It can be recommended that lactating women receive appropriate treatments for saving BMD during lactation.
Second and Early Third Trimester Atrial Natriuretic Peptide (ANP) Levels in Pregnancies Subsequently Complicated by Hypertension
Authors: Chung Tony K. H. , Rogers Michael S. , Baldwin Sally , Chang Allan M. S. , Nicholls M. Gary 
Published: August 2010

AbstractObjective: To explore the clinical utility of measuring atrial natriuretic peptide (ANP) in the second and early third trimesters of pregnancy in order to predict pregnancy induced hypertension (PIH).Methods and Materials: The study was done in a University Teaching Hospital. A prospective study of 200 women in their first pregnancy was conducted. ANP was measured at 2 gestational windows, 20–26 weeks and 30–34 weeks. This was correlated with pregnancy outcomes, in particular PIH. Student's t‐test was used to compare ANP levels between women who developed PIH and those who did not. The receiver operator curve (ROC) was used to determine its clinical utility.Results: ANP levels were lower at 20–26 weeks in women who subsequently developed PIH but there was no significant difference at 30–34 weeks between women who had normotensive pregnancies and those who later developed PIH. The character of the ROC would indicate that it is not useful for prediction.Conclusion: ANP levels in the second and early third trimesters has limited clinical utility for the prediction of PIH.
Laparoscopic Assisted Vaginal Hysterectomy: An Audit Plus a Word of Caution
Authors: Jones Ian S. C. , Flynn Michael , Hall Barbara , Perrin Lewis , Howland John 
Published: August 2010

AbstractLaparoscopic assisted vaginal hysterectomy (LAVH) performed in 109 cases has been reviewed. In this series the mean operative time was 89 minutes and mean inpatient hospitalization was 3.7 days. Throughout the review, 6 patients were considered to have major complications and each is discussed. The association of previous caesarean section and bladder damage is noted. LAVH widens the indications available for vaginal hysterectomy in younger women in whom the abdominal approach would previously be indicated, but extra caution is advised when this technique is first introduced to a gynaecological service.
Use of Bromodeoxyuridine, Proliferating Cell Nuclear Antigen, and Nucleolar Organizer Regions in the Multiparametric Assessment of Proliferating Potency in Cervical Intraepithelial Neoplasia
Authors: Kaneko Shigenobu , Izutsu Toshihiko 
Published: August 2010

AbstractThe authors analysed of the proliferative activity of intraepithelial neoplasia of the cervix utilizing the labeling index of monoclonal antibody to Bromodeoxyuridine (BrdU) or proliferating cell nuclear antigen (PCNA), and the number of Nucleolar organizer regions (Ag‐NOR). The BrdU labeling index (B.L.I.) for normal squamous epithelium, mild dysplasia, and moderate dysplasia were significantly lower than for severe dysplasia or carcinomain situ.The PCNA labeling index (P.L.I.) for normal squamous epithelium, mild dysplasia, and moderate dysplasia were significantly lower than for severe dysolasia or carcinomain situ.The number of Ag‐NOR dots of normal squamous epithelium and mild dysplasia were lower than those of severe dysplasia or carcinomain situ.There are significantly positive correlations of the B.L.I., P.L.I., and the number of Ag‐NORs in cervical intraepithelial neoplasia.
EGF‐R and Overexpression of the Oncogene c‐erbB‐2 in Ovarian Cancer: Immunohistochemical Findings and Prognostic Value
Authors: Meden H. , Marx D. , Raab T. , Kron M. , Schauer A. , Kuhn W. 
Published: August 2010

AbstractPurpose: The purpose of this study was to investigate the prognostic value of EGF‐R (c‐erbB‐1) compared to the overexpression of the c‐erbB‐2 oncogene product p185 in ovarian cancer.Patients and methods: The study was conducted on 266 previously untreated ovarian cancer patients with FIGO stage I–IV disease. EGF‐R and c‐erbB‐2 oncogene product p185 have been evaluated using immunohistochemistry. Survival times were analyzed according to the method described by Kaplan and Meier. For the simultaneous evaluation of the prognostic relevance of the analyzed factors, a Cox proportional hazards regression was performed.Results: EGF‐R was detected in 13%, and c‐erbB‐2 oncogene product p185 in 18% of primary tumors. EGF‐R showed no significant impact on the survival time, whereas c‐erbB‐2 oncogene product p185 positive patients had a significantly worse prognosis compared to p185 negative cases (p = 0.002). In the multivariate analysis, c‐erbB‐2 oncogene product p185, like tumor stage, histological grade and age, was found to be a significant prognostic factor.Conclusion: These data confirm the prognostic importance of the c‐erbB‐2; oncogene product p185 in ovarian cancer at the time of primary surgery, while EGF‐ R does not seem to have prognostic relevance.
Sublingual Nifedipine Compared with Intravenous Hydrallazine in the Acute Treatment of Severe Hypertension in Pregnancy: Potential for Use in Rural Practice
Authors: Jegasothy Ravindran , Paranthaman Sri 
Published: August 2010

AbstractObjectives: The purposes of this study were to compare the efficacy of sublingual nifedipine with intravenous hydrallazine in the control of acute hypertension of pregnancy and to make a preliminary assesment whether sublingual nifedipine could be recommended for use by midwives faced with severe hypertension in pregnancy in a rural setting.Methods: Subjects were 200 consecutive patients admitted to Kuala Terengganu General Hospital, Malaysia with severe hypertension in pregnancy between August 1989 and June 1990.Admission criteria were an ongoing viable pregnancy more than 28 weeks and diastolic blood pressure (DBP) more than 120 mmHg.The patients were randomly divided into 2 groups. In group I, sublingual nifedipine 5 mg was administered and repeated after 15 minutes if DBP > 120 mmHg; and in group II hydrallazine 5 mg was intravenously injected and repeated after 15 minutes if DBP > 120 mmHg. Both groups were put on hydrallazine infusion if DBP > 120 mmHg after 30 minutes. The Chi‐square test was used for analysis with significance at p < 0.05.Results: There was no statistical difference in the efficacy of therapy for decreasing blood pressure between the 2 groups. The groups were comparable by age, parity, gestational age at presentation, birth weight of infants, incidence of postpartum haemorrhage and fetal distress. Caesarian section rates were similar. In the observational studies on nurses administering the drugs, no significant difficulties were observed.Conclusion: Sublingual nifedipine was comparable to IV hydrallazine in the treatment of acute hypertension of pregnancy. Nurses were able to administer sublingual nifedipine without difficulty.
A Comparative Study of Outcome of Laparoscopic Salpingo‐Oophorectomy versus Open Salpingo‐Oophorectomy
Authors: Leetanaporn Roengsak , Tintara Hatern 
Published: August 2010

AbstractObjective: To determine the effectiveness and appropriateness of laparoscopic salpingo‐oophorectomy (LSO) versus open salpingo‐oophorectomy (OSO) in developing country.Method: A clinical study with historical control consisted of 31 LSO cases of benign ovarian cysts were compared with 41 OSO cases matched by diagnosis and difficulty.Results: The operative time of the LSO cases was higher (p < 0.001), but the morbidity was comparable (p = 0.22). The postoperative hospital stay of the LSO was shorter (p < 0.001). Patients who had LSO revealed meaningfully decreased postoperative use of analgesic (p < 0.05). The time to full recovery for LSO was shorter (p < 0.001), but the hospital charges were higher (p < 0.001).Conclusions: LSO is considerable safe and effective alternative to OSO but incurs higher hospital charges. The overall cost effectiveness of LSO, especially in the developing countries, need further evaluation.