bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Movement Disorders task force review of dysautonomia rating scales in Parkinson's disease with regard to symptoms of orthostatic hypotension
Authors: Pavy‐Le Traon Anne , Amarenco Gerard , Duerr Susanne , Kaufmann Horacio , Lahrmann Heinz , Shaftman Stephanie R. , Tison François , Wenning Gregor K. , Goetz Christopher G. , Poewe Werner , Sampaio Cristina , Schrag Anette , Stebbins Glenn T. , Rascol Olivier 
Published: May 2011

AbstractOrthostatic hypotension is defined as a blood pressure fall of > 20 mm Hg systolic and/or 10 mm Hg diastolic within 3 minutes of an upright position. The Movement Disorders Society commissioned a task force to assess existing clinical rating scales addressing symptoms of orthostatic hypotension in Parkinson's disease. Seven neurologists and a clinimetrician assessed each scale's previous use and critiqued its clinimetric properties. A scale was “recommended” if it had been applied to populations of patients with Parkinson's disease, with data on its use in studies beyond the group that developed the scale, and was found to be clinimetrically valid. A scale was considered “suggested” if it had been applied to Parkinson's disease, but only 1 of the other criteria was applied. A scale was “listed” if it met only 1 criterion. Symptoms of orthostatic hypotension are generally assessed in scales on wider autonomic or nonmotor symptoms. Some scales designed to detect orthostatic hypotension–related symptoms provide information on their severity: the AUTonomic SCale for Outcomes in PArkinson's Disease and the COMPosite Autonomic Symptom Scale met criteria for recommended with some limitations; the Novel Non‐Motor Symptoms Scale and the Orthostatic Grading Scale were classified as suggested. The Self‐completed Non‐Motor Symptoms Questionnaire for Parkinson's Disease was classified as suggested as a tool for screening orthostatic symptoms. However, these and the listed scales need further validation and application before they can be recommended for clinical use in patients with Parkinson's disease. © 2011 Movement Disorder Society
Docking and Molecular Dynamics Calculations of Pyrrolidinone Analog MMK16 Bound to COX and LOX Enzymes
Authors: Neophytou N. , Leonis G. , Stavrinoudakis N. , Simčič M. , Grdadolnik S. Golič , Papavassilopoulou E. , Michas G. , Moutevelis‐Minakakis P. , Papadopoulos M. G. , Zing M. , Mavromoustakos T. 
Published: May 2011

AbstractThe new molecule 4‐[(2S)‐2‐(1H‐imidazol‐1‐ylmethyl)‐5‐oxotetrahydro‐1H‐pyrrol‐1‐yl]methylbenzenecarboxylic acid (MMK16) was found to have promising anti‐inflammatory activity. This biological behavior of MMK16 triggered our interest to study its binding affinity using NMR spectroscopy in LOX and its docking and molecular dynamics (MD) properties in LOX and COX enzymes. The present NMR and docking binding studies not only rationalize the obtained biological results since in all three receptors MMK16 shows high affinity and scoring but also make it a potential dual LOX‐5/COX‐2 inhibitor. Thus, this class of molecules must be further investigated for discovering compounds possessing better biological activity and more lasting biological effect.
An iterative method for the shape reconstruction of the inverse Euler problem
Authors: Yan Wenjing , He Yaling , Ma Yichen 
Published: May 2011

AbstractThis article is concerned with the shape reconstruction for the inviscid fluid governed by the Euler equations. By formulating the domain derivative of the Euler equations and applying a regularized Gauss‐Newton iterative algorithm, the numerical examples are given for recovering the shape. The results show that our theory is useful for practical purpose and the proposed algorithm is feasible. © 2011 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq 28: 587–596, 2012
Analysis of a discontinuous galerkin method for heterogeneous diffusion problems with low‐regularity solutions
Authors: Di Pietro Daniele A. , Ern Alexandre 
Published: May 2011

AbstractWe study the convergence of the Symmetric Weighted Interior Penalty discontinuous Galerkin method for heterogeneous diffusion problems with low‐regularity solutions only belonging to W2, p with p ∈ (1,2]. In 2d, we infer an optimal algebraic convergence rate. In any space dimension d, we achieve the same result for p > 2 d/( d + 2). We also prove convergence without algebraic rates for exact solutions only belonging to the energy space. © 2011 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq, 2012
Late sequelae of symptomatic epidural compression in children with localized neuroblastoma
Authors: Angelini Paola , Plantaz Dominique , De Bernardi Bruno , Passagia Jean‐Guy , Rubie Hervé , Pastore Guido 
Published: May 2011

AbstractBackgroundTo describe late sequelae and their correlation with presenting clinical features and tumor treatment in children with symptomatic epidural compression (EC) secondary to localized neuroblastoma.ProceduresA total of 98 evaluable children diagnosed with neuroblastoma and EC, who survived a minimum of 2 years were identified in two Italian and French neuroblastoma series.ResultsSymptoms of EC at diagnosis included motor deficit in 94 cases and sphincter deficits in 33. Initial treatment was chemotherapy in 66 cases, neurosurgical decompression in 29 and radiotherapy in 3. Chemotherapy was chosen more frequently for younger children and for those with stage 3 disease. Overall treatment consisted of chemotherapy alone in 44 cases, neurosurgery and chemotherapy in 38, radiotherapy and chemotherapy, with or without neurosurgery, in 16. After a median follow‐up of 7.3 years, 57 children (58.2%) had one or more sequelae. Motor sequelae involved 50/57 of these children and correlated with age and severity of motor deficit at diagnosis and neurosurgical treatment. Spine deformities involved 27/57 children and were more frequent in those with severe motor deficit at diagnosis, or who were treated by neurosurgery or radiotherapy. Sphincter dysfunctions involved 31/57 children and were more frequent among children who presented with sphincter symptoms and severe motor deficit.ConclusionsFifty‐eight percent of the children with localized neuroblastoma and symptomatic EC registered in this study developed late sequelae. The severity of motor deficit at diagnosis was the main risk factor. Pediatr Blood Cancer 2011; 57: 473–480. © 2011 Wiley‐Liss, Inc.
Congenital pancytopenia and absence of B lymphocytes in a neonate with a mutation in the ikaros gene
Authors: Goldman Frederick D. , Gurel Zafer , Al‐Zubeidi Duha , Fried Ari J. , Icardi Michael , Song Chunhua , Dovat Sinisa 
Published: May 2011

AbstractBackgroundCongenital pancytopenia is a rare and often lethal condition. Current knowledge of lymphoid and hematopoietic development in mice, as well as understanding regulators of human hematopoiesis, have led to the recent discovery of genetic causes of bone marrow failure disorders. However, in the absence of mutations of specific genes or a distinct clinical phenotype, many cases of aplastic anemia are labeled as idiopathic, while congenital immune deficiencies are described as combined immune deficiency.ProcedureWe describe the case of a 33‐week gestation age male with severe polyhydramnios, hydrops, and ascites who was noted to be pancytopenic at birth. Bone marrow examination revealed a hypocellular marrow with absent myelopoiesis. An immune workup demonstrated profound B lymphopenia, near absent NK cells, and normal T cell number. Due to the similarity of the patient's phenotype with the IKAROS knockout mouse, studies were performed on bone marrow and peripheral blood to assess a potential pathogenic role of Ikaros.ResultsDNA studies revealed a point mutation in one allele of the IKAROS gene, resulting in an amino acid substitution in the DNA‐binding zinc finger domain. Functional studies demonstrated that the observed mutation decreased Ikaros DNA‐binding affinity, and immunofluorescence microscopy revealed aberrant Ikaros pericentromeric localization.ConclusionsOur report describes a novel case of congenital pancytopenia associated with mutation of the IKAROS gene. Furthermore, these data suggest a critical role of IKAROS in human hematopoiesis and immune development. Pediatr Blood Cancer 2012; 58: 591–597. © 2011 Wiley Periodicals, Inc.
Reduced bone mineral density in adult patients with Langerhans cell histiocytosis
Authors: Makras Polyzois , Terpos Evangelos , Kanakis George , Papatheodorou Athanasios , Anastasilakis Athanasios D. , Kokkoris Panagiotis , Kaltsas Gregory A. 
Published: May 2011

AbstractThis retrospective study evaluated bone mineral density (BMD) and bone turnover in adults with LCH. Twenty‐five adult patients and 25 matched controls were evaluated with BMD measurement and indices of bone metabolism. A BMD value below the expected range for age (Z‐score ≤ − 2.0) was found in 20% of patients; in particular, all postmenopausal women and men over 50‐years had either osteoporosis or osteopenia. Patients with active disease had significantly lower Z‐scores compared to patients with inactive disease and controls. Reduced bone turnover was found in all 14 patients treated with chemotherapy. No fractures due to osteoporosis were identified during 305.15 patient‐years of follow‐up. Pediatr Blood Cancer 2012; 58: 819–822. © 2011 Wiley Periodicals, Inc.
Cord blood iron profile and breast milk micronutrients in maternal iron deficiency anemia
Authors: El‐Farrash Rania Ali , Ismail Eman Abdel Rahman , Nada Ahmed Shafik 
Published: May 2011

AbstractBackgroundMicronutrient deficiencies among pregnant women are widespread in low‐income countries, including Egypt. Iron deficiency anemia (IDA) is the most frequent nutritional deficiency during pregnancy, with an impact on maternal and fetal morbidity and mortality. We aimed to evaluate the effect of maternal IDA and nutritional status on birth anthropometry, cord blood iron profile and breast milk micronutrients in 50 anemic (hemoglobin <11 g/dl) and 30 healthy pregnant women.ProcedureMaternal and neonatal anthropometric measures were recorded. Hemoglobin, red blood cell (RBC) indices, and indices of iron nutriture were measured in maternal and cord blood. Breast milk minerals; iron, copper, zinc, calcium, and magnesium were assessed.ResultsHemoglobin, RBC indices, and iron profile showed significant differences in the neonates born to anemic mothers compared to controls, particularly in moderate to severe anemia and linear correlations with maternal hemoglobin, iron, and ferritin levels were found (P < 0.01). Anthropometric measurements of anemic mothers and their neonates were positively correlated (P < 0.05). Breast milk micronutrients were significantly reduced in all anemic mothers showing significant relations with maternal serum iron (P < 0.01).ConclusionsMaternal IDA wields a significant influence on maternal and fetal nutritional status. IDA during pregnancy adversely affects both cord blood iron and breast milk mineral status, particularly in moderate to severe anemia and concurrent micronutrient deficiencies occur in maternal IDA. Further investigations including larger population of pregnant women with severe anemia are needed to verify the nutritional interrelation between maternal anemia and breast milk mineral status. Pediatr Blood Cancer 2012; 58: 233–238. © 2011 Wiley Periodicals, Inc.
A fast computational model to the simulation of non‐isothermal mold filling process in resin transfer molding
Authors: Saad Aouatif , Echchelh Adil , Hattabi Mohamed , Ganaoui Mohammed El 
Published: May 2011

AbstractThe numerical simulation of mass and heat transfer model for the curing stage of the resin transfer molding (RTM) process is known as a useful method to analyze the process before the mold is actually built. Despite the intense interest in the modeling and simulation of this process, the relevant work is currently limited to development of flow models during filling stage. Optimization of non‐isothermal mold filling simulation time without losing the efficiency remains an important challenge in RTM process. These were some reasons that motivate our work; namely the interested on the amelioration of the performance of RTM simulation code in term of execution time and memory space occupation. Our approach is accomplished in two steps; first by the modification of the control volume/ finite element method (CV/FEM) and second by the implementation in the modified code of an adapted conjugate gradient algorithm to the compressed sparse row storage scheme. The validity of our approach is evaluated with analytical results and excellent agreement was found. The results show that our optimization strategy leads to maximum reduction in time and space memory. This allows one to deal with problems with great and complex dimensions mostly encountered in RTM application field, without interesting in the constraint of space or time. POLYM. COMPOS., 2011. © 2011 Society of Plastics Engineers
Nonisothermal crystallization kinetics of polypropylene‐layered double hydroxide composites: Correlation with morphology
Authors: Penco Maurizio , Spagnoli Gloria , Arifur Rahman Md. , Passaglia Elisa , Coiai Serena , Ciardelli Francesco 
Published: May 2011

AbstractIn this work the effect of nanofiller on nonisothermal crystallization behavior of composites based on polypropylene (PP) was investigated by differential scanning calorimetry. The materials were prepared by melt mixing. Both an alkyl sulfonate salt modified layered double hydroxide (LDH) and an unmodified LDH were used as nanofillers and both PP and PP/polypropylene grafted with maleic anhydride (PP‐g‐MA) blend were used as matrices. The morphology of composites was investigated by X‐ray diffraction and transmission electron microscopy. No exfoliation was noticed in all prepared composites, but the hybrid materials showed an intercalated structure. The thermal properties and crystallization behavior were studied by conventional differential scanning calorimetry. In particular, the kinetic crystallization parameters were obtained using the modified Avrami equation for a nonisothermal process, whereas the activation energy of the global crystallization process was estimated using the Kissinger equation. The Avrami parameters suggest a significant effect on the crystallization of PP for the composites containing both the organically modified LDH and PP‐g‐MA. The results indicate a complex crystallization process of PP and evidence that the crystallization process can not be only explained by intercalation phenomenon, but the constrain effect ofpolymer chains on the filler surface and/or betweenthe filler clusters should play a significant role. POLYM. COMPOS., 2011. © 2011 Society of Plastics Engineers
Cellulose fiber‐reinforced polylactic acid
Authors: Frone A.N. , Berlioz S. , Chailan J.‐F. , Panaitescu D.M. , Donescu D. 
Published: May 2011

AbstractPolymer composites from polylactic acid (PLA) and two types of cellulose fibers obtained either by acid hydrolysis of microcrystalline cellulose (HMCC) or by mechanical disintegration of regenerated wood fibers (MF) were prepared and characterized. To enhance the compatibility of the cellulose fibers with PLA matrix, a surface treatment based on 3‐aminopropyltriethoxysilane (APS) was performed. The Fourier Transform Infrared (FTIR) spectroscopy was used to determine the chemical groups involved in the surface modification reaction. The silanization treatment resulted in different modifications on both types of cellulose fibers because of their different structural and morphological characteristics. The composites were prepared by incorporating 2.5% of the treated or untreated HMCC and MF into a PLA matrix using a melt‐compounding technique. An improved adhesion between the two phases of the composite materials was observed by scanning electron microscopy thanks to treatment. The dynamic mechanical thermal analyses showed that both untreated and silane treated fibers led to an improvement of the storage modulus of PLA in the glassy state. A higher enhancement of the storage modulus in the case of PLA/HMCC composites than the composites containing MF was obtained as a result of the high aspect ratio of these fibers which allows better matrix‐to‐filler stress transfer. Furthermore, the storage modulus of PLA composites was enhanced by silanization even at higher temperatures especially after thermal treatment. The cellulose fibers addition in PLA matrix modified significantly the relaxation phenomenon as observed in tan δ curves, emphasizing strongly modified molecular mobility of PLA macromolecules and crystallization changes. POLYM. COMPOS., 2011. © 2011 Society of Plastics Engineers.
Making Your Emotions Work for You: A pilot brief intervention for alexithymia with personality‐disordered offenders
Authors: McMurran Mary , Jinks Mary 
Published: May 2011

ABSTRACTOne strategy for reducing premature termination of therapy is to offer pre‐therapy preparation. Here, we describe an intervention targeting alexithymia in offenders with personality disorders. ‘Making Your Emotions Work for You’ is a one‐day group intervention consisting of four evidence‐based components: Psychoeducation, Recognizing Emotions, Self‐Awareness and Seeking Information. Pre‐intervention and post‐intervention scores on measures of alexithymia (Toronto Alexithymia Scale‐20 (TAS‐20)) and psychological mindedness (Balanced Index of Psychological Mindedness (BIPM)) are presented for five male personality‐disordered offenders. This small sample showed consistent scores in the dysfunctional direction on both psychometric measures, indicating that there does appear to be a need to address alexithymia in this group. Overall, participants reported positive experiences with the intervention. No reliable pre‐intervention to post‐intervention changes were observed on TAS‐20 scores. On the BIPM Interest scale, reliable improvement was observed for three participants and reliable deterioration for one participant. On the BIPM Insight scale, one participant reliably improved, and one reliably deteriorated. While alexithymia may not be changed by this intervention, participants may become more interested in exploring their emotions, which may enhance engagement in therapy. Copyright © 2011 John Wiley & Sons, Ltd.
Chiral Azo polyurethane(urea): Preparation, optical properties and low power consumption polymeric thermo‐optic switch
Authors: Liu Jinhua , Qiu Fengxian , Cao Guorong , Guan Yijun , Shen Qiang , Yang Dongya , Guo Qing 
Published: May 2011

AbstractAzo chromophore molecule (NPMBR) was synthesized by using 4‐nitroaniline, sodium nitrite and chiral reagent, R‐α‐methyl benzylamine. Then, NPMBR was polymerized with isophorone diisocyanate and polyether polyol to obtain novel chiral azo polyurethane(urea) (PUUR). The chemical structures of NPMBR and PUUR were characterized by FTIR and UV‐Vis spectroscopy. The UV‐induced trans/cis photoisomerization and reflex‐isomerization behaviors were investigated and the results indicated that the PUUR solution could undergo photochromism after irradiated by UV light. The measurements of refractive index and thermo‐optic coefficient (dn/dT) of PUUR were demonstrated at different wavelengths and different temperatures by ATR technique. By using CCD digital imaging devices, transmission loss of the internal waveguide was measured. The refractive index dispersions and Sellmeyer coefficients of PUUR were obtained by Sellmeyer equation. A Y‐branched switch based on thermo‐optic effect was proposed and the performance of switch was simulated. With branching angle of 0.143° and FD‐BPM method, the result showed that the power consumption of the thermo‐optic switch could be only 0.4 mW, and the response time of the switch could reach about 3 ms. It has a significant improvement in reducing the power consumption and response time compared with those of the normal Y‐branched polymer thermo‐optic switch. © 2011 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2011
Benchmark study on glyphosate‐resistant cropping systems in the United States. Part 6: Timeliness of economic decision‐making in implementing weed resistance management strategies
Authors: Weirich Jason W , Shaw David R , Coble Keith H , Owen Micheal DK , Dixon Philip M , Weller Stephen C , Young Bryan G , Wilson Robert G , Jordan David L 
Published: May 2011

AbstractBACKGROUND:The introduction of glyphosate‐resistant (GR) crops in the late 1990s made weed control in maize, cotton and soybean simple. With the rapid adoption of GR crops, many growers began to rely solely on glyphosate for weed control. This eventually led to the evolution of GR weeds. Growers are often reluctant to adopt a weed resistance best management practice (BMP) because of the added cost of additional herbicides to weed control programs which would reduce short‐term revenue. This study was designed to evaluate when a grower that is risk neutral (profit maximizing) or risk averse should adopt a weed resistance BMP.RESULTS:Whether a grower is risk neutral or risk averse, the optimal decision would be to adopt a weed resistance BMP when the expected loss in revenue is greater than 30% and the probability of resistance evolution is 0.1 or greater. However, if the probability of developing resistance increases to 0.3, then the best decision would be to adopt a weed resistance BMP when the expected loss is 10% or greater.CONCLUSION:Given the scenarios analyzed, risk‐neutral or risk‐averse growers should implement a weed resistance BMP with confidence that they have made the right decision economically and avoided the risk of lost revenue from resistance. If the grower wants to continue to see the same level of return, adoption of BMP is required. Copyright © 2011 Society of Chemical Industry
Herbicide‐resistant weed management: focus on glyphosate
Authors: Beckie Hugh J 
Published: May 2011

AbstractThis review focuses on proactive and reactive management of glyphosate‐resistant (GR) weeds. Glyphosate resistance in weeds has evolved under recurrent glyphosate usage, with little or no diversity in weed management practices. The main herbicide strategy for proactively or reactively managing GR weeds is to supplement glyphosate with herbicides of alternative modes of action and with soil‐residual activity. These herbicides can be applied in sequences or mixtures. Proactive or reactive GR weed management can be aided by crop cultivars with alternative single or stacked herbicide‐resistance traits, which will become increasingly available to growers in the future. Many growers with GR weeds continue to use glyphosate because of its economical broad‐spectrum weed control. Government farm policies, pesticide regulatory policies and industry actions should encourage growers to adopt a more proactive approach to GR weed management by providing the best information and training on management practices, information on the benefits of proactive management and voluntary incentives, as appropriate. Results from recent surveys in the United States indicate that such a change in grower attitudes may be occurring because of enhanced awareness of the benefits of proactive management and the relative cost of the reactive management of GR weeds. Copyright © 2011 Society of Chemical Industry