bluuebunny/crossref_metadata_2025_split huggingface dataset:
CONSUMPTION PATTERNS OF A VASSAL: THE CASE OF LACHISH AND JERUSALEM
Authors: Avisar Reli 
Published: February 2025

SummaryThis study analyzes the complex interplay of material culture, elite consumption and imperial power dynamics as they relate to the roles of Lachish and Jerusalem in the Iron IIA and to the formation of the Kingdom of Judah. Based on an analysis of luxury goods and social practices, it explores established interpretations of the geopolitical development of southern Canaan and challenges some of them.Analysis of the elite consumption patterns at the two sites reveals imperial and local Levantine powers functioning in the background: Aram Damascus in the Iron IIA, which used Lachish as a central hub; and Assyria in the Iron IIB–C, when Judah emerged as a regional player, and Jerusalem functioned as the southern centre of imperial interests, generating a significant transformation in the region’s geopolitical landscape.
Whose public reason? Which reasonableness?
Authors: Tahzib Collis 
Published: February 2025

AbstractRawlsian public reason liberalism holds that laws must be justified in terms of reasons that all reasonable citizens can accept. But who counts as a “reasonable” citizen? Rawlsians typically answer that reasonableness is conditional on acceptance of liberal values. But they do not typically defend this answer by explaining why the Rawlsian definition is superior to alternative possible definitions of reasonableness—for instance, libertarian reasonableness, perfectionist reasonableness, communitarian reasonableness, and so on. Once this full range of possibilities is set out in plain view, it creates a novel challenge which I call the which‐reasonableness challenge. This is the challenge of showing that the Rawlsian definition of reasonableness is superior to all the alternatives. In this paper, I set out this challenge (Section 1) and consider potential ways to overcome it: namely, by arguing that the Rawlsian definition of reasonableness is superior to the alternatives on grounds of its free‐standingness and stability (Section 2), its implicitness in the public political culture (Section 3), its anti‐sectarianism (Section 4), its fidelity to the underlying motivations of the public reason project (Section 5), and its avoidance of triviality, ad‐hocness, shoehorning and related perils (Section 6). I argue that while these considerations narrow the range of possible definitions of reasonableness, they do not do so by enough to uniquely pick out the Rawlsian definition. Rawlsian public reason liberals thus face a pressing challenge stemming from the simple question: Whose public reason? Which reasonableness?
Identification of the Novel HLA‐DQB1*06:524 Allele by Sanger Dideoxy Nucleotide Sequencing
Authors: Zhang Dan , Wang Dongmei , Liu Na , Sun Tiecheng , Wang Lijun 
Published: February 2025

ABSTRACTThe HLA‐DQB1*06:524 allele differs from HLA‐DQB1*06:02:43 by one nucleotide substitution in codon 57 in exon 2.
Common, Intermediate and Well‐Documented HLA Alleles in the Brazilian Population: An Analysis of the Brazilian Bone Marrow Donor Registry (REDOME)
Authors: da Silva Jose Samuel , Visentainer Jeane Eliete Laguila , Fabreti‐Oliveira Raquel Aparecida , de Souza Felipe Carlos Brito , Silva Marcio Nogueira Pereira , da Costa Sena Alexandre , Goldenstein Monica , Claudino Renata Esterque , de Souza Mendonça‐Mattos Patricia Jeanne , Motta Juliana Pessanha Rodrigues , Secco Danielle Angst , Oliveira Danielli , Porto Luís Cristóvão 
Published: February 2025

ABSTRACTThis study investigates the HLA allele diversity in Brazil, a reflection of the country's unique history of population admixture. The international comparison of findings emphasises the importance of incorporating underrepresented populations into global HLA databases. We present a comprehensive analysis of HLA alleles within the Brazilian population, utilising high‐resolution sequencing data from 298,000 unrelated haematopoietic stem cell volunteer donors registered with the Brazilian Bone Marrow Donor Registry (REDOME). Our research encompasses donors from all regions of Brazil, identifying HLA alleles that are catalogued as common, intermediate or well‐documented (CIWD Version 3.0). We evaluated the alleles of HLA‐A, HLA‐B, HLA‐C, HLA‐DRB1, HLA‐DQA1, HLA‐DQB1, HLA‐DPA1 and HLA‐DPB1. At a two‐field resolution, we identified 1969 alleles: 418 were classified as common, 358 as intermediate and 1193 as non‐CIWD in Brazil. Notably, we report HLA alleles that, while not classified as common or intermediate in the CIWD 3.0 catalogue, are prevalent within the Brazilian population. A detailed list of alleles from the registry, presented at a two‐field resolution and supplemented with grouped ARD levels, including three‐ or four‐field resolution when available, serves as an essential reference for HLA typing frequencies specific to the Brazilian population.
Characterisation of the Novel HLA‐DRB1*13:01:44 Allele by Sequencing‐Based Typing
Authors: Pajot Thibault , Elsermans Vincent , Top Isabelle , Labalette Myriam 
Published: February 2025

ABSTRACTHLA‐DRB1*13:01:44 differs from HLA‐DRB1*13:01:01:01 by one nucleotide substitution in codon 180 in exon 3.
Effectiveness of a Brief Mindfulness‐Based Intervention on Compassion Fatigue and Compassion Satisfaction in Pediatric Nurses
Authors: AL‐Jdeetawey Nid'a A. , Al‐Hammouri Mohammed Munther , Rababah Jehad A. , Ta'an Wafa'a F. , Suliman Mohammad 
Published: February 2025

ABSTRACTBackgroundUnlike other medical practitioners, nurses working in pediatric intensive care units face uniquely challenging workplace conditions because they care for preterm newborns and critically ill patients. These workplace challenges led to increased compassion fatigue (i.e., burnout and secondary traumatic stress) and decreased compassion satisfaction. Compassion fatigue and compassion satisfaction strongly influence the quality of care and patient outcomes, and these need to be addressed through effective interventions such as mindfulness‐based interventions.AimThis study aimed to examine the impact of a brief mindfulness‐based intervention on compassion fatigue and compassion satisfaction among pediatric intensive care nurses.MethodsA quasi experimental study with a pretest posttest design was used to recruit 204 nurses: 102 in the intervention group and 102 in the control group with randomization by hospital (n = 4). The brief mindfulness‐based intervention was delivered over 6 weeks. Data were collected using a demographics questionnaire and the Professional Quality of Life Scale, Version 5.ResultsThe intervention group's mean scores of burnout and secondary traumatic stress were significantly lower postinterventions compared with the control group. Similarly, the mean compassion satisfaction score for the intervention group indicated a significant improvement post‐intervention compared with the control group. Additional evidence for the effectiveness of the intervention was the disappearance of low compassion satisfaction, high burnout, and high secondary traumatic stress categorizations postintervention in the intervention group, contrary to the control group.Linking Evidence to ActionImplementing brief mindfulness‐based interventions can improve pediatric intensive care nurses' well‐being by reducing burnout and secondary traumatic stress while enhancing compassion satisfaction. By using the study's findings, nurse managers can make these practices essential for high‐quality care and effective workforce management.Trial RegistrationClinicalTrials.gov identifier: ACTRN12622000389707
Association of Gait Speed With Cognitive Outcomes in Older Adults With Hypertension: A Secondary SPRINT MIND Analysis
Authors: Mirzai Saeid , Volk Maximilian C. , Kazibwe Richard , Gabani Mohanad , Schaich Christopher L. , Hammonds Racquel , Seals Austin , Singleton Matthew J. , Yeboah Joseph , Shapiro Michael D. , Herrington David , Kitzman Dalane W. , Hughes Timothy M. , Williamson Jeff D. , Kritchevsky Stephen B. 
Published: February 2025

Background/Objectives: Hypertension is linked to slower walking pace and cognitive decline, but the ability of slow gait to predict dementia in older adults with hypertension is unclear. This study examined whether slow baseline gait predicts future cognitive impairment in older adults with hypertension enrolled in the Systolic Blood Pressure Intervention Trial (SPRINT) Memory and Cognition in Decreased Hypertension (MIND) study. Methods: SPRINTMIND randomized adults ≥50 years of age with hypertension to intensive (target systolic blood pressure <120 mmHg) or standard (<140 mmHg) blood pressure control. Baseline gait speed was measured in participants ≥75 years of age. We defined slow gait as speed ≤0.8 m/s. Outcomes were probable dementia (pD), mild cognitive impairment (MCI), and composite pD or MCI. Results: Among 2,351 participants, 33.3% had slow baseline gait. Over median 4-year follow-up, the slow gait group had higher rates of incident pD (13.5% vs 6.4%), MCI (19.4% vs 11.9%), and pD or MCI (29.2% vs 16.3%) compared with normal gait. Adjusted Cox regression models revealed that slow gait was associated with a 1.85-fold higher risk of pD (95% confidence interval [1.37, 2.50], p < .001), 1.52-fold higher risk of MCI (95% confidence interval [1.20, 1.93], p = .001), and 1.61-fold higher risk of pD or MCI (95% confidence interval [1.32, 1.97], p < .001). Intensive blood pressure control did not significantly affect cognitive outcomes in either gait group. Conclusion: Slow gait speed predicts increased cognitive decline risk among older adults with hypertension. Significance/Implications: Gait speed assessment can identify older adults with hypertension at higher risk of cognitive decline, allowing earlier intervention to potentially delay progression.
Anti-NMDA receptor encephalitis following Murray Valley encephalitis: a case report
Authors: Yerramilli Arvind , Ramachandran Prashanth , Burston John , Howard-Jones Annaleise R. , Lim Chuan Kok , Kok Jen , Fitzpatrick Leigh , Hingston Peter , Jackson Justin 
Published: February 2025

ABSTRACT

Background
Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is an autoimmune condition that is increasingly being recognized as a complication of central nervous system infections. While association with herpes simplex virus encephalitis is well established, the condition has also been reported to occur following Japanese encephalitis virus infection and yellow fever vaccination.

Case Summary
Here, we report a case of anti-NMDA receptor encephalitis following infection with Murray Valley encephalitis virus (MVEV), another virus of the family Flaviviridae. Following initial recovery, and 34 days after the onset of illness, our patient developed autonomic instability, orofacial dyskinesia, and decreased level of consciousness. Diagnosis was established with the detection of anti-NMDA receptor antibodies in cerebrospinal fluid. Immunosuppressive therapy with rituximab and corticosteroids resulted in a favorable outcome.

Conclusion
This case report raises awareness of post-viral autoimmune encephalitis which should be considered in patients with a biphasic pattern of illness following viral encephalitis or a compatible clinical syndrome. Given the initial diagnosis of Murray Valley encephalitis, clinicians should be alert to the possibility of MVEV as an infectious trigger associated with the development of anti-NMDA receptor encephalitis. We also highlight the challenges inherent in the diagnosis of flavivirus infections, which may require a combination of clinical, epidemiological, and laboratory evidence.
Severe accidental poisonings in children: a British Paediatric Surveillance Unit nationwide prospective study
Authors: King Charlotte , Anderson Mark , Agarwal Abhishek , Fakis Apostolos , Parry Christopher M , Lynn Richard Michael , Hawcutt Daniel B , Starkey Elizabeth Sarah 
Published: February 2025

BackgroundPoisoning in children and young people is common. Understanding the incidence, causes and circumstances of severe accidental poisonings, requiring admission and medical intervention, may help healthcare professionals and shape public health interventions.MethodsA prospective, population-based surveillance study using the British Paediatric Surveillance Unit (BPSU)’s active surveillance methodology (July 2018–July 2019) in the UK and Ireland. Inclusion criteria were as follows: all children aged <15 years; accidental poisoning requiring intervention; Poisoning Severity Score (PSS) score ≥2 (moderate or severe). Intentional poisonings were excluded.Results116 cases of poisoning were reported, and 31 cases met the inclusion criteria. The overall incidence of reported severe accidental poisoning was 2.4 cases per million children (3.2 per million in male, 1.6 per million in female), with 7.3 cases per million in children under 2 years. On PSS scoring, 14 (45%) cases were classified as moderate, 16 (52%) cases severe and 1 (3%) case fatal. The frequency of fatal poisonings reported was 0.08 per million children. Prescription medications were the most common substance implicated (n=13, 42%), with opioids (n=6, 19%) being the most common medication group. Common non-medication causes were illicit drugs or alcohol (n=12, 39%), household or industrial products (n=5, 16%), and carbon monoxide (n=1, 3%). The most cited circumstance was ‘the substance being left unattended’ (n=8, 26%).ConclusionSevere accidental poisoning remains a significant problem for children, but the most common causes have changed, underscoring the importance of updating public health initiatives.
Feasibility, acceptability and preliminary effectiveness of the Hospital to Home discharge and follow-up programme in rural Uganda: a mixed-methods intervention study
Authors: Niyonshaba Beatrice , Kabugo Daniel , Nakiganda Cornety , Otai Christine , Seela Margret , Nankabala Joyce , Nyonyintono James , Nakakande Josephine , Kigozi Tadeo , Vaughan Madeline , Nakamura Heidi , Paudel Mohan , Haddix-McKay Kimber , al-Haddad Benjamin J S , Tann Cally J , Mubiri Paul , Waiswa Peter , Magnusson Brooke 
Published: February 2025

IntroductionOver 60% of premature infants are born in Africa or South Asia. Infants born early, small or who become sick after birth have a higher risk of death, poor growth and developmental impairments. Innovative interventions tailored for low- and middle-income countries are essential to help these newborns survive and develop optimally. This study evaluated the feasibility, acceptability and preliminary effectiveness of Hospital to Home (H2H), a discharge and follow-up programme for small and sick newborns in rural Uganda.MethodsWe compared two cohorts of high-risk hospitalised neonates in Uganda: a historical-comparison cohort receiving standard facility-based care and an intervention cohort that received the H2H programme, a hospital and community spanning package of interventions designed to improve neurodevelopmental outcomes. We compared 6-month corrected neurodevelopmental, growth, nutritional and vaccination outcomes between the cohorts complemented by qualitative interviews of caregivers, community health workers and health facility staff.ResultsWe recruited 191 participants: 91 historical-comparison cohort (born between July and September 2018), and 100 intervention cohort (born July 2019 to February 2020). No statistically significant difference was seen in neurodevelopmental outcomes (adjusted OR 0.68; 95% CI: 0.32 to 1.46). Improved vaccination completion (88.5% intervention vs 76.9% comparison, p=0.041), and exclusive breastfeeding rates (42% vs 6.6%, p<0.001) were seen. Caregivers and healthcare workers reported the intervention to be acceptable and feasible in this rural Ugandan setting.ConclusionThe H2H programme was feasible and acceptable to caregivers and healthcare providers. Improved vaccination and exclusive breastfeeding rates were seen in the intervention group when compared with a historical comparison cohort in this rural Ugandan setting. Further investigation on the short and long-term effectiveness of the H2H programme in a government health services setting is warranted.Trial registration numberISRCTN51636372.
Trends in the prevalence and factors associated with indoor smoking in 24 countries Party to the WHO FCTC: implications for equitable policy implementation
Authors: Odo Daniel Bogale , Ayo-Yusuf Olalekan , Dinku Yonatan , Mekonnen Alemayehu Gonie , Maddox Raglan 
Published: February 2025

IntroductionThe health consequences of secondhand smoke (SHS) are a long-standing concern. The WHO Framework Convention on Tobacco Control (FCTC) is an evidence-based treaty that aims to protect people from health and environmental harms of commercial tobacco use and exposure to SHS. This study quantified the prevalence of daily smoking inside the house (indoor smoking) and change over time and examined the determinants of indoor smoking in 24 WHO FCTC Parties.MethodsWe used data from the 2 most recent Demographic and Health Surveys (DHS) from 24 countries. Counties were selected if they submitted at least one FCTC implementation report and had two DHS surveys conducted after 2010. The weighted prevalence and percentage changes in daily indoor smoking in the two consecutive surveys were calculated, including rate of change, and a two-sample test of proportions was used to assess changes. Multinomial logistic regression model was employed to examine the association between socioeconomic characteristics and indoor smoking. All results were presented by country.ResultsA significant decline in the prevalence of daily indoor smoking was detected in 16/24 countries, with the rate of decline ranging from −45.8% in Liberia to −15.2% in India. Jordan reported a significant increase in daily indoor smoking from 57% to 60%; p=0.002. The meta-analytical estimate showed that overall, the relative risk ratio (RRR) of daily indoor smoking was significantly lower for households in the 5th wealth quintile compared with counterparts in the 1st quintile (RRR=0.40; 95% CI: 0.30 to 0.52), and in households where head of the household attended higher education compared with no formal education (RRR=0.60; 95% CI: 0.53 to 0.69).ConclusionsThis study demonstrated that prevalence of daily indoor smoking was associated with low socioeconomic status. Reducing SHS exposure is critical, including addressing inequities to help improve health outcomes. Currently, over 2.8 billion people in low-income countries are not protected by smoke-free environment laws, and only 18% of the world’s population is covered by strong restrictions on tobacco marketing.
Association between high-sensitivity C-reactive protein and bleeding in dual antiplatelet therapy age: a retrospective observational study
Authors: He Wen-fei , Zeng Li-huan , Lin Zi-jing , Chen Peng-yuan , Liu Yuan-hui , Duan Chongyang , Jiang Lei , Guo Zhi-qiang , He Peng-cheng 
Published: February 2025

ObjectivesThe aim of the present study was to investigate the association of high-sensitivity C-reactive protein (hs-CRP) with bleeding events among patients with acute coronary syndrome (ACS) received dual antiplatelet therapy (DAPT) after percutaneous coronary intervention.DesignAn observational and multicentre study was conducted among non-ST-segment elevation ACS (NSTE-ACS).SettingThe study was conducted at five medical centres in China.ParticipantsThis study retrospectively included 2583 adults with NSTE-ACS between 1 January 2010 and 31 December 2014.Primary and secondary outcome measuresThe primary outcome was major bleeding, defined by the Bleeding Academic Research Consortium definition (grades 3–5). The second outcome was death and any bleeding.Results53 (2.1%) patients experienced major bleeding in the hospital. Patients with hs-CRP levels greater than 8.20 mg/L had the highest incidence of in-hospital major bleeding (25 (3.9%), p<0.001) compared with the other groups. Multivariable analysis indicated that hs-CRP was an independent factor associated with in-hospital major bleeding (continuous: adjusted OR=1.01, 95% CI: 1.01 to 1.02, p<0.001; quartiles: adjusted OR for quartile 4 (referring to quartile 1) =3.71, 95% CI: 1.35~10.23, p=0.011), which was further confirmed by subgroup analysis and receiver operating characteristic curves. The restricted cubic spline analysis demonstrated an S-shaped association between hs-CRP and major bleeding. During the 5-year follow-up, there was a significantly high risk of bleeding in patients with higher hs-CRP levels.ConclusionsSystemic inflammation marker hs-CRP in patients with NSTE-ACS who received DAPT is associated with a high risk of in-hospital major bleeding. An S-shaped association was found between hs-CRP and bleeding events. Further studies are warranted to optimise antithrombotic drug therapy in high bleeding risk patients during follow-up.
Development and validation of a questionnaire on parental health literacy in the context of promoting healthy lifestyles during childhood: a study protocol
Authors: Flügel Verena , Hering Thomas , Dadaczynski Kevin 
Published: February 2025

IntroductionBecoming a parent presents profound changes and numerous challenges, notably the necessity for reliable information regarding their child’s health. Given the overabundance of information available today, it is important for parents to acquire the skills necessary to find, understand, evaluate and apply health information. Research demonstrates that this ability, known as parental health literacy (PHL), is crucial for developing and maintaining a healthy lifestyle during childhood. However, there is currently no reliable instrument for measuring PHL in the field of prevention and health promotion. This paper presents the development and validation of a new questionnaire designed to assess parents’ ability to process health-related information to support the healthy development of their children aged 3–6 years.Methods and analysisThe development of the item pool is based on Sørensenet al’s conceptualisation of general health literacy (finding, understanding, evaluating and applying health information). Empirical findings suggest that communication with healthcare providers and the social network represents another important skill area for parents and is therefore included as an additional subscale. The questionnaire will be developed in four stages, including a literature search and analysis, expert consultations via Delphi study, cognitive interviews with parents and a validation study. The validation study uses exploratory (EFA) and confirmatory factor analysis (CFA) for construct validity, first identifying test dimensions through EFA, then confirming these dimensions with CFA to ensure the factor structure aligns with theoretical expectations. This methodology, alongside reliability and correlational analyses, seeks to assess the questionnaire’s validity and reliability, expecting strong correlations with existing related constructs.Ethics and disseminationEthical approval was obtained from the Ethics Committee of Fulda University of Applied Sciences. All participants receive a consent form together with the study information, in which they give their written consent to the storage, processing and linking of all data collected. The results of the study will be presented at national and international conferences and published in specialist journals.Trial registration numberDRKS00033482.