bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uncovering further diversity of Ochoterenatrema Caballero, 1943 (Digenea: Lecithodendriidae) in South American bats
Authors: Tkach Vasyl V. , Gasperetti Roxanne , Fernandes Thayane F. , Carrión-Bonilla Carlos A. , Cook Joseph A. , Achatz Tyler J. 
Published: May 2024

AbstractOchoterenatrema Caballero, 1943 is a genus of lecithodendriid digeneans that prior to this study included 8 species parasitic in bats in the Western Hemisphere. Species of Ochoterenatrema possess a unique morphological feature in form of the pseudogonotyl on the sinistral side of the ventral sucker. In this study, we describe 2 new species of Ochoterenatrema from bats in Ecuador. The new species are readily differentiated from their congeners by a combination of morphological characters, including the distribution of vitelline follicles, length of oesophagus, sucker ratio and the body shape, among other features. We have generated partial nuclear 28S rDNA and mitochondrial cox1 gene DNA sequences from both new species. The newly obtained sequences were used to differentiate among species and study the phylogenetic interrelationships among Ochoterenatrema spp. The internal topology of the clade was weakly supported, although the cox1 tree was much better resolved than the 28S tree. Comparison of sequences revealed 0–1.2% interspecific divergence in 28S and 3.3–20.5% interspecific divergence in cox1 among Ochoterenatrema spp. The new findings demonstrate that bats in South America likely harbor multiple additional undescribed species of Ochoterenatrema. More extensive sampling from broader geographic and host ranges, especially in North America, should allow for a better understanding of the evolution of host associations and morphological traits of this lineage of lecithodendriid digeneans.
Green synthesis of silver nanoparticles using Hebeloma excedens mushroom extract as a new source: Anti-lipid peroxidation, bioaccessibility and antidiabetic properties
Authors: Okumus Emine 
Published: May 2024

AbstractA traditional source of natural bioactive compounds, mushrooms are used to synthesize biomaterials, thanks to their potential applications in the medicine, pharmacology and cosmetics industries. In this study, the vitamin C and E contents of the Hebeloma excedens mushroom species were determined as 64.2 mg/g and 38.6 mg/g, respectively. In the mineral substance analysis, the highest amount of magnesium (32.16 mg/g) and trace amounts of iron (0.22 mg/g) were detected. In the nanoparticles (AgNPs/He) synthesized using this mushroom species, the colour of the mixture first changed to dark brown and exhibited maximum absorption at 428 nm, corresponding to the surface plasmon resonance. Fourier transform infrared spectroscopy (FTIR) results revealed the binding properties of the biocomponents responsible for coating and stabilizing the nanoparticles. The resulting nanostructures were much more stable than the mushroom extract and showed strong antioxidant activity (22.93 mg/ml). A significant decrease in phenolic compounds was observed after the gastrointestinal digestion process applied to the mushroom extract and AgNPs/He samples (p < 0.05). However, a significant increase in the bioaccessibility of phenolic compounds was detected in AgNPs/He particles (p < 0.05). It was determined that there was a significant increase in the thermal stability, inhibition against lipid peroxidation (6.64 mg/ml) and antidiabetic activities (29.20 mg/ml) of silver structures synthesized using the green synthesis method. As a result, the existence and current potential of a new biomaterial suitable for cost-effective and large-scale production in the synthesis of AgNPs/He has been demonstrated for the first time.
Oncological outcomes post transoral robotic surgery (TORS) for HPV-associated oropharyngeal squamous cell carcinoma, a single-centre retrospective Australian study
Authors: Kornfeld Belen , Taha Ahmed , Kyang Lee , Sim Hao-wen , Dewhurst Suzannah , McCloy Rachael , Chin Vanessa , Earls Peter , Parker Andrew , Leavers Brett , Forstner Dion , Floros Peter , Crawford Julia , Gallagher Richard 
Published: May 2024

AbstractWe present a cohort review of TORS resection for HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) and its associated oncological outcomes spanning a 10-year period. A retrospective case series review was performed of patients undergoing primary surgical treatment for HPV-associated OPSCC through the St. Vincent’s Head and Neck Cancer service from 2011 to 2022. The primary outcomes were to investigate complete resection of the primary tumour, rates of recurrence, and survival analysis. Secondary outcomes included complications, rates of adjuvant therapy, sites of recurrence and rates of percutaneous endoscopic gastrostomy (PEG). 184 patients underwent TORS-based therapy with neck dissection, and guideline-directed adjuvant therapy for HPV-associated OPSCC. Our median follow-up was 46 months. The positive margin rate on final histopathology analysis was 10.9%. Adjuvant therapy was indicated in 85 patients (46%). The local recurrence rate was 10.9% with the majority (80%) of patients recurring in the first 3 years since treatment. The disease-specific survival at 3 years was 98.6% and at 5 years was 94.4%. The 3-year and 5-year OS for the cohort was 96.7% and 92.5%, respectively. The presence of extranodal extension and positive margins were associated with increased risk of recurrence, whereas adjuvant therapy was found to be a protective factor for both overall recurrence and survival. Major complications occurred in 12 patients (6.5%), resulting in one death. This study has demonstrated that primary surgical therapy for HPV-associated OPSCC is a safe and effective treatment modality with low local recurrence and complication rates, and overall survival benefits.
Ladybird predators in natural and agricultural landscapes in Mexico: diversity and parasitism
Authors: Mendoza-Arroyo W. , del-Val E. 
Published: May 2024

AbstractLadybirds (Coleoptera: Coccinellidae) are a significant predator group that plays a role in agricultural contexts. They serve as important biocontrol agents against several agricultural pests. However, there is limited information available about how ladybirds’ populations are regulated by their natural enemies and habitat perturbation. In this study, we evaluated ladybird communities associated with natural and managed areas during the agricultural cycle of 2018 (June–September). We identified seven ladybird species; the most abundant species were Hippodamia convergens (70% individuals) and Cycloneda sanguinea (20% individuals), followed by the exotic species Harmonia axyridis (3.33% individuals), while Paranaemia vittigera, Coleomegilla maculata, Brachiacantha sp., and Olla v-nigrum represented less than 3% each. Ladybirds were more abundant in agricultural fields than in natural habitats. We identified several natural enemies associated with the collected ladybirds, including parasitoids (Dinocampus coccinellae, Hymenoptera: Braconidae), ectoparasitic Acari (Coccipolipus sp., Podapolipidae), and nematodes (Mermithidae). However, none of the natural enemies affected more than 10% of the ladybirds, so natural enemies do not appear to be exerting substantial control over their populations. Our results corroborated that ladybirds can efficiently thrive in anthropogenic habitats in Mexico and therefore may represent good biocontrol agents for agriculture. It is important to consider the ecology of agriculturally important ladybirds in programs for integrated pest management. This includes factors contributing to the mortality of ladybirds, including their natural enemies.
Nerve Injury Following Regional Nerve Block: A Literature Review of Its Etiologies, Risk Factors, and Prevention
Authors: Bais Kimmy , Guirguis Fady , Guirguis Mina 
Published: May 2024

Abstract
Purpose of Review
Postoperative nerve injury after nerve block is complex and multifactorial. The mechanisms, etiologies, and risk factors are explored. This review article conducts a literature search and summarizes current evidence and best practices in prevention of nerve injury.

Recent Findings
Emerging technology such as ultrasound, injection pressure monitors, and nerve stimulators for peripheral nerve block have been incorporated into regular practice to reduce the rate of nerve injury. Studies show avoidance of intrafascicular injection, limiting concentrations/volumes of local anesthetic, and appropriate patient selection are the most significant controllable factors in limiting the negative consequences of nerve block.

Summary
Peripheral nerve injury is an uncommon occurrence after nerve block and is obscured by surgical manipulation, positioning, and underlying neural integrity. Underlying neural integrity is not always evident despite an adequate history and physical exam. Surgical stress, independently of nerve block, may exacerbate these neurologic disease processes and make diagnosing a postoperative nerve injury more challenging. Prevention of nerve injury by surgical teams, care with positioning, and avoidance of intrafascicular injection with nerve block are the most evidence-based practices.
Protective Effect of CXCR7 Against Hypoxia/Reoxygenation Injury in Renal Tubular Epithelial Cells
Authors: Meng Ping , Liu Chunli , Li Jingchun , Fang Ping , Chen Liling 
Published: May 2024

AbstractAcute kidney injury (AKI) is a multifactorial syndrome with complex pathophysiology and prognosis. Ischaemia‒reperfusion injury (IRI) is a major cause of induced AKI. The aim of this study was to investigate the effect of upregulated CXCR7 expression on renal tubular epithelial cell apoptosis induced by hypoxia/reoxygenation (H/R). HK-2 cells were divided into three groups: control group (pcDNA3.1), hypoxia/reoxygenation + pcDNA3.1 group (H/R+pcDNA3.1) and CXCR7 overexpression + hypoxia/reoxygenation group (H/R+ Flag-CXCR7). Protein levels of renal tubular epithelial cell injury-, apoptosis- and autophagy-related markers were assessed by qRT‒PCR, Western blotting, flow cytometry (FCM), immunofluorescence and transmission electron microscopy (TEM). In addition, HK-2 cells were treated with the autophagy inhibitor 3-MA and divided into 3 groups: control group, 3-MA + pcDNA3.1 group, and 3-MA + Flag-CXCR7 group. Changes in autophagy and apoptosis in renal tubule epithelial cells were assessed by Western blotting and FCM. Compared with those in the control group, the protein and mRNA expression levels of CXCR7 in HK-2 cells were significantly lower under H/R conditions. Under H/R conditions, CXCR7 overexpression in HK-2 cells significantly downregulated the expression of NGAL. Moreover, CXCR7 overexpression significantly decreased H/R-induced cleaved PARP-1 and cleaved Caspase 3 levels, increased the level of the antiapoptotic protein BCL-2 and the autophagy-related molecules ATG5 and LC3B II, and significantly inhibited the expression of P62. Autophagy flow and TEM also showed that CXCR7 significantly promoted autophagy. CXCR7 significantly alleviated the 3-MA-induced inhibition of autophagy and increase in apoptosis. Upregulated CXCR7 expression can inhibit renal tubular epithelial cell apoptosis and damage by regulating autophagy. In conclusion, CXCR7 is a promising target for the prevention and/or treatment of AKI.
A General Integral Identity with Applications to a Reverse Serrin Problem
Authors: Magnanini Rolando , Molinarolo Riccardo , Poggesi Giorgio 
Published: May 2024

AbstractWe prove a new general differential identity and an associated integral identity, which entails a pair of solutions of the Poisson equation with constant source term. This generalizes a formula that the first and third authors previously proved and used to obtain quantitative estimates of spherical symmetry for the Serrin overdetermined boundary value problem. As an application, we prove a quantitative symmetry result for the reverse Serrin problem, which we introduce for the first time in this paper. In passing, we obtain a rigidity result for solutions of the aforementioned Poisson equation subject to a constant Neumann condition.
Improving motion management in radiation therapy: findings from a workshop and survey in Australia and New Zealand
Authors: Claridge Mackonis Elizabeth , Stensmyr Rachel , Poldy Rachel , White Paul , Moutrie Zoë , Gorjiara Tina , Seymour Erin , Erven Tania , Hardcastle Nicholas , Haworth Annette 
Published: May 2024

AbstractMotion management has become an integral part of radiation therapy. Multiple approaches to motion management have been reported in the literature. To allow the sharing of experiences on current practice and emerging technology, the University of Sydney and the New South Wales/Australian Capital Territory branch of the Australasian College of Physical Scientists and Engineers in Medicine (ACPSEM) held a two-day motion management workshop. To inform the workshop program, participants were invited to complete a survey prior to the workshop on current use of motion management techniques and their opinion on the effectiveness of each approach. A post-workshop survey was also conducted, designed to capture changes in opinion as a result of workshop participation. The online workshop was the most well attended ever hosted by the ACPSEM, with over 300 participants and a response to the pre-workshop survey was received from at least 60% of the radiation therapy centres in Australia and New Zealand. Motion management is extensively used in the region with use of deep inspiration breath-hold (DIBH) reported by 98% of centres for left-sided breast treatments and 91% for at least some right-sided breast treatments. Surface guided radiation therapy (SGRT) was the most popular session at the workshop and survey results showed that the use of SGRT is likely to increase. The workshop provided an excellent opportunity for the exchange of knowledge and experience, with most survey respondents indicating that their participation would lead to improvements in the quality of delivery of treatments at their centres.
Hypomineralised second primary molars: the Würzburg concept
Authors: Bekes K. , Steffen R. , Krämer N. 
Published: May 2024

Abstract
Purpose
In addition to molar incisor hypomineralisation, the occurrence of enamel hypomineralisation in the primary dentition has become increasingly important in recent years. Hypomineralised second primary molar (HSPM) is defined as hypomineralisation of systemic origin affecting from one to all four second primary molars. Some years ago, the “Würzburg concept” was introduced, which proposed a grading of MIH findings (MIH treatment need index) in combination with an appropriate treatment plan depending on the severity of the affected tooth. Recently, this concept was updated and new treatment approaches have been added. However, currently, the concept solely addresses the treatment plan for permanent teeth. As there is a need to expand its scope to encompass primary teeth and, consequently, HSPM, this paper seeks to develop the second component of the Würzburg concept, the treatment plan, for the primary dentition in response to the increased focus on the disease in recent years. Although the evidence base for the different treatment options is still weak, there is a need for guidance for clinicians in their day-to-day practice.

Methods
The authors conducted a comprehensive review of the literature, encompassing clinical and laboratory studies along with published guidelines.

Results
The treatment plan of the HSPM Würzburg concept contains prophylactic and regenerative aspects, non-invasive interventions, temporary and permanent restorative techniques, and extraction.

Conclusions
The intention is to provide practical guidance to practitioners, acknowledging the necessity for further validation through clinical trials.
The Ketogenic Diet as a Treatment for Mood Disorders
Authors: Ozan Elif , Chouinard Virginie-Anne , Palmer Christopher M. 
Published: May 2024

Abstract
Purpose of Review
The ketogenic diet is a low carbohydrate, moderate protein, and high fat diet which results in a metabolic state known as ketosis, in which fats are broken down into ketone bodies. The ketogenic diet is a 100-year-old evidence-based treatment for epilepsy and is gaining popularity as a treatment for various mental disorders, including mood disorders. Our objective is to explain the potential mechanisms through which ketogenic diets may improve the pathophysiology of mood disorders and provide a comprehensive review of recent clinical literature on the topic

Recent Findings
Mood disorders are associated with several proposed pathophysiological mechanisms, including mitochondrial dysfunction, oxidative stress, inflammation, and insulin resistance. The ketogenic diet shows promise in addressing these underlying pathophysiological mechanisms and emerging clinical data suggest that ketogenic diets may improve symptoms in people with mood disorders.

Summary
The ketogenic diet shows promise in the treatment of mood disorders. This metabolic intervention has the potential to directly target underlying disease mechanisms, potentially reduce the need for medications, and reduce common side effects and comorbidities, such as weight gain and insulin resistance.
Discrete element model for effective electrical conductivity of spark plasma sintered porous materials
Authors: Nisar F. , Rojek J. , Nosewicz S. , Szczepański J. , Kaszyca K. , Chmielewski M. 
Published: May 2024

AbstractThis paper aims to analyse electrical conduction in partially sintered porous materials using an original resistor network model within discrete element framework. The model is based on sintering geometry, where two particles are connected via neck. Particle-to-particle conductance depends on neck size in sintered materials. Therefore, accurate evaluation of neck size is essential to determine conductance. The neck size was determined using volume preservation criterion. Additionally, grain boundary correction factor was introduced to compensate for any non-physical overlaps between particles, particularly at higher densification. Furthermore, grain boundary resistance was added to account for the porosity within necks. For numerical analysis, the DEM sample was generated using real particle size distribution, ensuring a heterogeneous and realistic microstructure characterized by a maximum-to-minimum particle diameter ratio of 15. The DEM sample was subjected to hot press simulation to obtain geometries with different porosity levels. These representative geometries were used to simulate current flow and determine effective electrical conductivity as a function of porosity. The discrete element model (DEM) was validated using experimentally measured electrical conductivities of porous NiAl samples manufactured using spark plasma sintering (SPS). The numerical results were in close agreement with the experimental results, hence proving the accuracy of the model. The model can be used for microscopic analysis and can also be coupled with sintering models to evaluate effective properties during the sintering process.
Anti-corruption disclosure: evidence from the natural experiment of the Non-Financial Reporting Directive
Authors: Aluchna Maria , Kamiński Bogumił , Wrzosek Małgorzata 
Published: May 2024

AbstractDrawing upon institutional theory, we investigate how companies react to coercive pressures which impose anti-corruption disclosure practices. We adopt the concept of change in the institutionalized field and investigate the impact of the natural experiment of the Non-Financial Reporting Directive (NFRD) implementation on a company’s choice for disclosing its anti-corruption policy. We examine the relationship between firm linkages with the external environment, proxied by board independence and ownership dispersion, and anti-corruption disclosure. We use a sample of 72 companies listed on the Warsaw Stock Exchange over the period of 2015–2019 that were subject to the NFRD legislation. The evidence from the Tobit model shows that the linkages with the external environment differentiate company reactions to the implementation of the mandatory reporting legislation. In particular, greater company linkages via interdependent directors and ownership dispersion increase the scope of the anti-corruption disclosure in the post-NFRD period. Our study offers policy implications suggesting that corporate scrutiny and exposure to external constituencies may improve implementation of legislation into company practice and enhance anti-corruption disclosure.
A Working Framework to Address Diversity, Equity, and Inclusion in Undergraduate Medical Education
Authors: Jiang K. , Blumer J. B. , Zaveri N. T. , Schneid S. D. , Lee E. M. , Szarek J. L. , Kruidering M. , Quesnelle K. M. , Lee M. W. 
Published: May 2024

AbstractHealth disparities exist among groups that are based on race, ethnicity, gender, socioeconomic status, and geography. Often, interventions directed at addressing these disparities are episodically incorporated into health professions education as opposed to a more uniform integration throughout a curriculum. Thus, a working framework for integrating and assessing diversity, equity, and inclusion (DEI) specifically into foundational science teaching in health professions’ education is needed. Current frameworks are theoretically based and often bereft of practical examples that basic science and clinical educators would find useful in educational settings. Here we analyzed examples in pharmacology, therapeutics, and clinical medicine to create a tool aimed at identifying and remediating biases and disparities across the undergraduate medical education (UME) curriculum. We initially focused on pharmacology examples and performed a literature search followed by an in-depth analysis of the literature together with our experiences teaching topics with a DEI component. It became clear that, in addition to pure pharmacology topics, there are many pharmacology- and therapeutics-related topics that also involve race, gender, and sexual orientation. These include clinical guidelines and clinical screening criteria. Further analysis of all of the examples derived from our multi-faceted analysis revealed common themes that we, in turn, compiled into a framework. This framework can be used by foundational science and clinical educators to help both students and faculty understand how to navigate DEI-associated foundational science content.
From Liberal Democracy to Illiberal Populist Autocracy: Possible Reasons for Hungary’s Autocratization
Authors: Halmai Gábor 
Published: May 2024

AbstractThe paper looks for the main reasons of how was the Hungarian government of the Fidesz Party lead by Prime Minister Viktor Orbán able to within 13 years undermine the independent checks on their power so that it could convert what had looked like a stable but imperfect democracy into an autocracy? After listing the most obvious reasons the paper looks particularly at, how much is the way of a mostly elite-driven democratic transition using the tools of ‚legal constitutionalism‘and ‚undemocratic liberalism‘without real historical traditions of a liberal democratic constitutional culture and with the regionally determined value system is to blame. This also leads to the question, how to allocate the responsibility for the backsliding between the elites and the citizens, influenced and often manipulated by the leaders.