bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: A Magnetic Nanoparticle Supported Dual Acidic Ionic Liquid: A “Quasi‐homogeneous” Catalyst for the One‐Pot Synthesis of Benzoxanthenes.
Authors: Zhang Qiang , Su Hong , Luo Jun , Wei Yunyang 
Published: May 2012

AbstractThe three‐component condensation of naphthol (I), aldehyde (II), and dimedone (III) is catalyzed by action of a “quasi‐homogeneous” catalyst, due to a combination of nano‐support features and flexible imidazolium linkers.
ChemInform Abstract: Design and Synthesis of Novel Cytotoxic Agents Based on Combined Framework of Quinoline and Nimesulide.
Authors: Reddy Lingam Venkata , Kethavath Mohan , Nakka Mamatha , Beevi Syed Sultan , Mangamoori Lakshmi Narasu , Mukkanti Khagga , Pal Sarbani 
Published: May 2012

AbstractAmong a variety of nimesulide‐derived Morita—Baylis—Hillman adducts (III), derivative (IIIc) shows the highest in vitro activity against human prostate cancer cell lines.
ChemInform Abstract: MCM‐41‐SO3H as a Nanoreactor for the One‐Pot, Solvent‐Free Synthesis of 1,8‐Dioxo‐9‐aryl Decahydroacridines.
Authors: Rostamizadeh Shahnaz , Amirahmadi Asiyeh , Shadjou Nasrin , Amani Ali M. 
Published: May 2012

AbstractCyclocondensation of dimedone (I) with aromatic aldehydes and ammonium acetate proceeds in short reaction times with high yields in the presence of MCM‐41‐SO3H catalyst.
ChemInform Abstract: Palladium(II)/Copper Halide/Solvent Combination for Selective Intramolecular Domino Reactions of Indolecarboxylic Acid Allylamides: An Unprecedented Arylation/Esterification Sequence.
Authors: Broggini Gianluigi , Barbera Vincenzina , Beccalli Egle M. , Borsini Elena , Galli Simona , Lanza Giuseppe , Zecchi Gaetano 
Published: May 2012

AbstractIndolylallylamides (I) and (IX) undergo intramolecular oxidation reactions in the presence of PdCl2(MeCN)2 and CuCl2 to produce functionalized β‐carbolinones (II).
ChemInform Abstract: Synthesis of Pyrazolo[3,4‐b]pyridines under Microwave Irradiation in Multi‐Component Reactions and Their Antitumor and Antimicrobial Activities. Part 1.
Authors: El‐borai M. A. , Rizk H. F. , Abd‐Aal M. F. , El‐Deeb I. Y. 
Published: May 2012

AbstractMost synthesized compounds (IV) and (VI) exhibit antimicrobial activity, while compounds (VIa) and (VIc) show significant activity against HEPG2 human liver cancer cell line.
ChemInform Abstract: Substituted Azabicyclo[2.2.1]heptanes via Nitrenium Ion Rearrangement.
Authors: Piotrowski David W. , Rolph Marianne , Wei Liuqing 
Published: May 2012

AbstractN‐Chlorination of exo‐arylated bicyclic substrates and subsequent AgNO3‐mediated nitrenium ion rearrangement produces endo‐arylated products, which represent the skeleton of pharmaceutically important alkaloid systems.
ChemInform Abstract: Synthetic Studies on Novel 1,4‐Dihydro‐2‐methylthio‐4,4,6‐trisubstituted Pyrimidine‐5‐carboxylic Acid Esters and Their Tautomers.
Authors: Nishimura Yoshio , Okamoto Yasuko , Ikunaka Masaya , Ohyama Yoshihiko 
Published: May 2012

AbstractTitle compounds (V) and (VI) are synthesized by Atwal—Biginelli cyclocondensation of oxoesters (III), obtained by the Lehnert procedure for the Knoevenagel‐type condensation with S‐methylisothiourea salt (IV).
ChemInform Abstract: Hydrazonoyl Halides as Precursors for New Fused Heterocycles of 5α‐Reductase Inhibitors.
Authors: Farghaly Thoraya A. , Gomha Sobhi M. , Abbas Eman M. H. , Abdalla Mohamed M. 
Published: May 2012

AbstractFused heterocycles (III), (V), and (VII) are synthesized by reaction of thione (I) or its methyl derivative with hydrazonoyl halides of type (II).
ChemInform Abstract: New Lithium‐Zincate Approaches for the Selective Functionalization of Pyrazine: Direct Dideprotozincation vs. Nucleophilic Alkylation.
Authors: Baillie Sharon E. , Blair Victoria L. , Blakemore David C. , Hay Duncan , Kennedy Alan R. , Pryde David C. , Hevia Eva 
Published: May 2012

AbstractTwo new bimetallic approaches for the selective 2,5‐dideprotonation and chemoselective room temperature C‐H alkylation of pyrazine are presented.
ChemInform Abstract: One‐Pot Synthesis of Macrocyclic Di‐ and Tetralactones Using [2 + 2] Photocycloaddition Reactions of Di‐2‐pyrones with α,ω‐Diolefins
Authors: Zhang Hui Min , Kawabata Kazuya , Miyauchi Hideki , Shimo Tetsuro 
Published: May 2012

Abstract5 examples
ChemInform Abstract: [1,5]‐Anion Relay/[2,3]‐Wittig Rearrangement of 3,3‐Bis(silyl) Allyl Enol Ethers: Synthesis of Useful Vinyl Bis(silane) Species.
Authors: Sun Xianwei , Lei Jian , Sun Changzhen , Song Zhenlei , Yan Linjie 
Published: May 2012

AbstractA new strategy to trisubstituted vinylsilanes is developed: the vinyl bissilanes can be transformed into trisubstituted vinylsilanes through a [1,4]‐Brook rearrangement/alkylation protocol using different electrophiles.
ChemInform Abstract: Elaborating on Efficient Antiproliferation Agents of Cancer Cells and Antiinflammatory‐Based N‐Bisphosphonic Acids.
Authors: Abdou Wafaa M. , Khidre Rizk E. , Kamel Azza A. 
Published: May 2012

AbstractQuinoline based bisphosphonates [(III), (VI), (IX), and (XII)] and corresponding phosphonic acids [(IV), (VII), (X), and (XIII)] are synthesized via Michael addition and hydrolysis.
ChemInform Abstract: Convenient Peptide Synthesis Without Protection of C‐Terminals.
Authors: Noguchi Takuya , Tehara Naoka , Uesugi Yuki , Jung Seunghee , Imai Nobuyuki 
Published: May 2012

AbstractA convenient protocol for the condensation of carboxylic acids with unprotected α‐amino acids via activation by ethyl chloroformate and triethylamine is presented.
ChemInform Abstract: Two New Alkaloids from Crinum asiaticum var. sinicum.
Authors: Kogure Noriyuki , Katsuta Noriko , Kitajima Mariko , Takayama Hiromitsu 
Published: May 2012

Abstractisolation and structure determination of two new alkaloids, seco‐isopowellaminone (I), and crinamine N‐oxide (II)
ChemInform Abstract: A New Lycopodine Alkaloid from Huperzia serrata
Authors: Shan Wei‐Guang , Ren Feng‐Yun , Ying You‐Min , Tong Cui‐Ping , Zhan Zha‐Jun 
Published: May 2012

Abstractisolation and structure elucidation of 6α,11α‐dihydroxylycopodine (I)
The Development of FtsZ Inhibitors as Potential Antibacterial Agents
Authors: Ma Siti , Ma Shutao 
Published: May 2012

AbstractThe emergence and prevalence of bacterial resistance has resulted in a clear demand for novel antibacterial drugs. As a tubulin homologue, FtsZ is an essential cell‐division protein in prokaryotic organisms and is showing increasing promise as a target for antibacterial drug discovery. This review describes the role of FtsZ in bacterial cytokinesis and various FtsZ inhibitors, with particular focus on their discovery, antibacterial activities, mechanisms of action, synthetic methods, and representative analogues.
Strategies in Sustainable Supply Chain Management: An Empirical Investigation of Large German Companies
Authors: Harms Dorli , Hansen Erik G. , Schaltegger Stefan 
Published: May 2012

ABSTRACTCompanies which manage global supply chains face a high level of complexity with a large number of suppliers in diverse socio‐economic contexts and growing expectations of customers and standardization schemes to control social and environmental aspects. In the context of sustainable development, the effective management of supplier relationships has therefore attracted particular attention in sustainable supply chain management (SSCM). This paper investigates two SSCM strategic approaches in Germany's largest stock companies with regard to supplier management. Supplier evaluation and selection adopts a risk‐oriented strategic perspective whereas supplier development represents a business‐opportunity‐oriented approach to managing supplier chains for sustainable products. The survey‐based analysis reveals that large German stock companies mainly implement risk‐oriented SSCM strategies. Copyright © 2012 John Wiley & Sons, Ltd and ERP Environment
New class of filter functions generated directly by the modified Christoffel–Darboux formula for classical orthonormal Jacobi polynomials
Authors: Pavlović Vlastimir D. 
Published: May 2012

ABSTRACTThe new solution of determining the prototype analogue filter function as the response that satisfies the specifications of all pole low‐pass continual time filter functions of odd and even order is presented in this article.The approximation problem of filter function was solved mathematically, applying the summed Christoffel–Darboux formula for the orthonormal polynomials. The starting point in solving the approximation problem is the direct application of the Christoffel–Darboux formula for the initial set of continual Jacobi orthonormal polynomials in the finite interval [−1, + 1] in full respect to the weighting function with two free real parameters.Solution for the monotonic and non‐monotonic filter functions is obtained in an explicit form, which is shown to enable generation of the Jacobi filter functions in a simple way by choosing the values of the free real parameters.Moreover, the proposed solution with the same criterion of approximation is used to generate for particular specifications the appropriate best known classical approximation functions of free parameters: the Gegenbauer, Legendre, and Chebyshev filter functions of the first and second kind as well. The example of the proposed all‐pole low‐pass lossless LC filter in the frequency domain for frequency responses of the 11th‐order filter is illustrated.This work is concerned with the approximation of an all‐pole low‐pass filter to design a circuit assuring an optimum realization of the required specifications. The article proposes new class filter functions with an approach to ideal filter magnitude characteristic. Copyright © 2012 John Wiley & Sons, Ltd.
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ILF‐3 is a regulator of the neural plate border marker Zic1 in chick embryos
Authors: Fishwick K. J. , Kim E. , Bronner M. E. 
Published: May 2012

AbstractBackground: The neural crest is a multipotent cell type unique to the vertebrate lineage and capable of differentiating into a large number of varied cell types, including ganglia of the peripheral nervous system, cartilage, and glia. An early step in neural crest specification occurs at the neural plate border, a region defined by the overlap of transcription factors of the Zic, Msx, and Pax families. Results: Here we identify a novel chick gene with close homology to double‐stranded RNA‐binding protein Interleukin enhancer binding factor 3 (ILF‐3) in other species. Our results show that chick Ilf‐3 is required for proper expression of the transcription factor, Zic‐1, at the neural plate border. Conclusion: We have identified a novel chick gene and show it has a role in the correct specification of Zic‐1 at the neural plate border. Developmental Dynamics 241:1325–1332, 2012. © 2012 Wiley Periodicals, Inc.
Cholinergic‐associated loss of hnRNP‐A/B in Alzheimer's disease impairs cortical splicing and cognitive function in mice
Authors: Berson Amit , Barbash Shahar , Shaltiel Galit , Goll Yael , Hanin Geula , Greenberg David S. , Ketzef Maya , Becker Albert J , Friedman Alon , Soreq Hermona 
Published: May 2012

AbstractGenetic studies link inherited errors in RNA metabolism to familial neurodegenerative disease. Here, we report such errors and the underlying mechanism in sporadic Alzheimer's disease (AD). AD entorhinal cortices presented globally impaired exon exclusions and selective loss of the hnRNP A/B splicing factors. Supporting functional relevance, hnRNP A/B knockdown induced alternative splicing impairments and dendrite loss in primary neurons, and memory and electrocorticographic impairments in mice. Transgenic mice with disease‐associated mutations in APP or Tau displayed no alterations in hnRNP A/B suggesting that its loss in AD is independent of Aβ and Tau toxicity. However, cholinergic excitation increased hnRNP A/B levels while in vivo neurotoxin‐mediated destruction of cholinergic neurons caused cortical AD‐like decrease in hnRNP A/B and recapitulated the alternative splicing pattern of AD patients. Our findings present cholinergic‐mediated hnRNP A/B loss and impaired RNA metabolism as important mechanisms involved in AD.
Adult tree swallow survival on the polychlorinated biphenyl–contaminated Hudson River, New York, USA, between 2006 and 2010
Authors: Custer Christine M. , Custer Thomas W. , Hines James E. 
Published: May 2012

Abstract
The upper Hudson River basin in east central New York, USA, is highly contaminated, primarily with polychlorinated biphenyls (PCBs). Reduced adult survival has been documented in tree swallows (Tachycineta bicolor) at a similarly PCB-contaminated river system in western Massachusetts. The purpose of the present study was to assess whether adult survival of tree swallows was likewise affected in the Hudson River basin. Between 2006 and 2010, a total of 521 female tree swallows were banded, of which 148 were retrapped at least once. The authors used Program MARK and an information theoretic approach to test the hypothesis that PCB contamination reduced annual survival of female tree swallows. The model that best described the processes that generated the capture history data included covariate effects of year and female plumage coloration on survival but not PCB/river. Annual survival rates of brown-plumaged females (mostly one year old) were generally lower (mean phi = 0.39) than those of blue-plumaged females (mean phi = 0.50, one year or older). Poor early spring weather in 2007 was associated with reduced survival in both plumage-color groups compared to later years. Models with the effects of PCB exposure on survival (all ΔAICc values &gt;5.0) received little support. Environ. Toxicol. Chem. 2012; 31: 1788–1792. © 2012 SETAC
Mercury in litterfall and upper soil horizons in forested ecosystems in Vermont, USA
Authors: Juillerat Juliette I. , Ross Donald S. , Bank Michael S. 
Published: May 2012

Abstract
Mercury (Hg) is an atmospheric pollutant that, in forest ecosystems, accumulates in foliage and upper soil horizons. The authors measured soil and litterfall Hg at 15 forest sites (northern hardwood to mixed hardwood/conifer) throughout Vermont, USA, to examine variation among tree species, forest type, and soils. Differences were found among the 12 tree species sampled from at least two sites, with Acer pensylvanicum having significantly greater litterfall total Hg concentration. Senescent leaves had greater Hg concentrations if they originated lower in the canopy or had higher surface:weight ratios. Annual litterfall Hg flux had a wide range, 12.6 to 28.5 µg/m2 (mean, 17.9 µg/m2), not related to forest type. Soil and Hg pools in the Oi horizon (litter layer) were not related to the measured Hg deposition flux in litterfall or to total modeled Hg deposition. Despite having lower Hg concentrations, upper mineral soil (A horizons) had greater Hg pools than organic soil horizons (forest floor) due to greater bulk density. Significant differences were found in Hg concentration and Hg/C ratio among soil horizons but not among forest types. Overall, our findings highlight the importance of site history and the benefits of collecting litterfall and soils simultaneously. Observed differences in forest floor Hg pools were strongly correlated with carbon pools, which appeared to be a function of historic land-use patterns. Environ. Toxicol. Chem. 2012; 31: 1720–1729. © 2012 SETAC
Screening for DSM‐IV‐TR cognitive disorder NOS in Parkinson's disease using the Mattis Dementia Rating Scale
Authors: Pontone Gregory M. , Palanci Justin , Williams James R. , Bassett Susan Spear 
Published: May 2012

ObjectiveThis study explores the utility of the Mattis Dementia Rating Scale (MDRS) as a screening tool for the Diagnostic and Statistical Manual for Mental Disorders 4th edition (DSM‐IV‐TR) diagnosis cognitive disorder not otherwise specified (NOS) in Parkinson's disease (PD).MethodsA total of 125 individuals with PD were diagnosed using DSM‐IV‐TR criteria for cognitive disorder NOS and dementia. Receiver operating characteristics (ROC) tested the discriminant validity of the MDRS, with the clinician's diagnosis serving as the gold standard.ResultsThe MDRS ROC curve to discriminate subjects with cognitive disorder NOS from non‐demented subjects had an area under the curve of 0.59 (standard error = 0.08, 95% CI: 0.43–0.74).ConclusionsThe MDRS is not effective for identifying PD patients with cognitive disorder NOS without dementia. Copyright © 2012 John Wiley & Sons, Ltd.
IS THERE EMPIRICAL EVIDENCE FOR DECREASING RETURNS TO SCALE IN A HEALTH CAPITAL MODEL?
Authors: Galama Titus J. , Hullegie Patrick , Meijer Erik , Outcault Sarah 
Published: May 2012

ABSTRACTWe estimate a health investment equation, derived from a health capital model that is an extension of the well‐known Grossman model. Of particular interest is whether the health production function has constant returns to scale, as in the standard Grossman model, or decreasing returns to scale, as in the Ehrlich–Chuma model and extensions thereof. The model with decreasing returns to scale has a number of theoretically and empirically desirable characteristics that the constant returns model does not have. Although our empirical equation does not point‐identify the decreasing returns to scale curvature parameter, it does allow us to test for constant versus decreasing returns to scale. The results are suggestive of decreasing returns and in line with prior estimates from the literature. But when we attempt to control for the endogeneity of health by using instrumental variables, the results become inconclusive. This brings into question the robustness of prior estimates in this literature. Copyright © 2012 John Wiley & Sons, Ltd.
A comparison of adverse impact levels based on top‐down, multisource, and assessment center data: Promoting diversity and reducing legal challenges
Authors: John Bernardin H. , Konopaske Robert , Hagan Christine M. 
Published: May 2012

AbstractWe compared levels of adverse impact (AI) against minorities and women based on three promotional decision methods for 428 associate store managers of a Fortune 500 retailer: top‐down appraisal (TDA), multisource appraisal (MSA), and an assessment center (AC). We found significant effects for race and minority status (favoring whites) but no significant effects for gender across all three methods. Comparisons were analyzed using two definitions of AI (four‐fifths rule and the Fisher Exact Test) with a selection ratio (SR) of .25. No evidence of AI was found against blacks for any of the methods. For Hispanics, AI was found under the four‐fifths rule for the AC. For women, the four‐fifths rule was violated using TDA. Results provide some partial support for the argument that diversity goals are more likely to be met using assessment centers compared to TDA when the preponderance of raters are white men. Our data also suggest that carefully crafted, job‐related, top‐down appraisal, combined with rater training, may be effective in facilitating the promotion of more women and minorities and reducing the probability of legal problems. © 2012 Wiley Periodicals, Inc.
Screening‐oriented recruitment messages: Antecedents and relationships with applicant pool quality
Authors: Dineen Brian R. , Williamson Ian O. 
Published: May 2012

AbstractThe ability of firms to attract qualified job applicants is a critical component of the human resource management process. However, while a large body of research has examined the relationship between firm recruitment practices and applicant pool attributes, very little research has investigated what factors are associated with organizational decision makers' utilization of specific recruitment tactics. We draw on labor economics, sociological, and agency theoretical perspectives to make predictions regarding the use of screening‐oriented recruitment messages in actual web‐based job advertisements. Results suggest that perceptions of labor supply, recruiting firm reputation, and the use of quality‐based compensation incentives are associated with use of screening‐oriented messages, which in turn are associated with applicant pool quality. These findings hold important theoretical insights into the factors shaping firm recruitment activity and provide practical strategic implications for managing firm recruitment objectives. © 2012 Wiley Periodicals, Inc.
Further experience with the local lymph node assay using standard radioactive and nonradioactive cell count measurements
Authors: Kolle Susanne N. , Basketter David , Schrage Arnhild , Gamer Armin O. , van Ravenzwaay Bennard , Landsiedel Robert 
Published: May 2012

ABSTRACTIn a previous study, the predictive capacity of a modified local lymph node assay (LLNA) based on cell counts, the LNCC, was demonstrated to be closely similar to that of the original assay. In addition, a range of substances, including some technical/commercial materials and a range of agrochemical formulations (n = 180) have also been assessed in both methods in parallel. The results in the LNCC and LLNA were generally consistent, with 86% yielding an identical classification outcome. Discordant results were associated with borderline data and were evenly distributed between the two methods. Potency information derived from each method also demonstrated good consistency (n = 101), with 93% of predictions being close. Skin irritation was observed only infrequently and was most commonly associated with positive results; it was not associated with the discordant results. Where different vehicles were used with the same test material, the effect on sensitizing activity was modest, consistent with historical data. Analysis of positive control data indicated that the LNCC and LLNA displayed similar levels of biological variation. When taken in combination with the previously published results on LLNA Performance Standard chemicals, it is concluded that the LNCC provides a viable non‐radioactive alternative to the LLNA for the assessment of substances, including potency predictions, as well as for the evaluation of preparations. Copyright © 2012 John Wiley & Sons, Ltd.
Sonography for appendicitis: Nonvisualization of the appendix is an indication for active clinical observation rather than direct referral for computed tomography
Authors: Stewart Jessica K. , Olcott Eric W. , Jeffrey R. Brooke 
Published: May 2012

AbstractPurpose.To determine the prevalence of perforated and nonperforated appendicitis in patients with nonvisualization of the appendix on ultrasound (US) performed for suspected appendicitis, and to evaluate the value of CT in these patients.Methods.We analyzed 400 consecutive patients undergoing US for suspected appendicitis. Of these patients, 260 had nonvisualization of the appendix, but otherwise normal scans. We analyzed the clinical outcome in these patients to determine the prevalence of appendicitis, referrals for CT, and the contribution of CT in these patients.Results.Of the 400 patients, 140 (35%) had either a normal (80 patients, 25%) or an abnormal appendix (60 patients, 15%); 260 (65%) had nonvisualization of the appendix. Overall 75 patients had appendicitis (18.8%) and 17 (4.3%) had appendicitis with perforation. Of the 260 patients with nonvisualization of the appendix, 14 patients (5.4%) had appendicitis and 2 were perforated (0.8%). The prevalence of perforated and nonperforated appendicitis in this group was significantly lower than the overall group (p < 0.001 and p < 0.01, respectively). Of these 260 patients, 101 patients (38.8%) had CT within 48 hours and 79 (78.2%) had normal scans.Conclusions.Patients with nonvisualization of the appendix on US, but otherwise normal scans, are at significantly lower risk for appendicitis, either perforated or nonperforated. Active clinical observation should be considered in these patients, rather than direct referral for CT. © 2012 Wiley Periodicals, Inc. J Clin Ultrasound 40:455–461,2012