bluuebunny/crossref_metadata_2025_split huggingface dataset:
Apple Down 152: A putative case of syphilis from sixth century AD Anglo‐Saxon England
Authors: Cole Garrard , Waldron Tony 
Published: August 2010

AbstractThis report describes a putative case of a treponemal infection observed on a skeleton of a young male adult from the Apple Down Anglo‐Saxon cemetery dating to the sixth century AD, accompanied by grave goods indicative of a high status burial. The skeleton is well preserved and almost complete. The pathological evidence includes an extensive area of lytic destruction to the frontal bone of the skull, widespread profuse bilateral symmetrical periosteal reaction affecting scapulae, clavicles, arms, legs, hands, feet and ribs. There is also evidence of gummatous destruction on some of the long bones. Application of a differential diagnosis of all probable diseases exhibiting the individual symptoms leads to a clear conclusion that the person was infected with a treponemal pathogen. The skeleton shows none of the stigmata associated with the congenital form of treponemal disease. We propose that the evidence suggests a possible case of venereal syphilis rather than one of the endemic forms of treponemal disease. This diagnosis is based on the geographical pathogen range, the apparent low prevalence of the disease, significant social upheaval at the time, the high social status and early age of death of the individual. Am J Phys Anthropol, 2010. © 2010 Wiley‐Liss, Inc.
Endocrinology of year‐round reproduction in a highly seasonal habitat: Environmental variability in testosterone and glucocorticoids in baboon males
Authors: Gesquiere Laurence R. , Onyango Patrick O. , Alberts Susan C. , Altmann Jeanne 
Published: August 2010

AbstractIn conditions characterized by energetic constraints, such as in periods of low food availability, some trade‐offs between reproduction and self‐maintenance may be necessary; even year‐round breeders may then be forced to exhibit some reproductive seasonality. Prior research has largely focused on female reproduction and physiology, and few studies have evaluated the impact of environmental factors on males. Here we assessed the effects of season and ambient temperatures on fecal glucocorticoid (fGC) and testosterone (fT) levels in male baboons in Amboseli, Kenya. The Amboseli basin is a highly challenging, semiarid tropical habitat that is characterized by strongly seasonal patterns of rainfall and by high ambient temperatures. We previously reported that female baboons were impacted by these challenging environmental conditions. We ask here whether male baboons in the same environment and groups as females exhibit similar physiological effects. We found that after accounting for male age and individual variability, males exhibited higher fGC levels and lower fT levels during the dry season than during the wet season. Furthermore, fT but not fGC levels were lower in months of high average daily maximum temperatures, suggesting a direct impact of heat on testes. Our results demonstrate that male baboons, like females, experience ecological stress that alters their reproductive physiology. The impact of the environment on male reproduction deserves more attention both in its own right and because alteration in male physiology may contribute to the reduction in female fertility observed inchallenging environments. Am J Phys Anthropol, 2011. © 2010 Wiley‐Liss, Inc.
Semiconductor Gas Sensors: Dry Synthesis and Application
Authors: Tricoli Antonio , Righettoni Marco , Teleki Alexandra 
Published: August 2010

AbstractSince the development of the first chemoresistive metal oxide based gas sensors, transducers with innovative properties have been prepared by a variety of wet‐ and dry‐deposition methods. Among these, direct assembly of nanostructured films from the gas phase promises simple fabrication and control and with the appropriate synthesis and deposition methods nm to μm thick films, can be prepared. Dense structures are achieved by tuning chemical or vapor deposition methods whereas particulate films are obtained by deposition of airborne, mono‐ or polydisperse, aggregated or agglomerated nanoparticles. Innovative materials in non‐equilibrium or sub‐stoichiometric states are captured by rapid cooling during their synthesis. This Review presents some of the most common chemical and vapor‐deposition methods for the synthesis of semiconductor metal oxide based detectors for chemical gas sensors. In addition, the synthesis of highly porous films by novel aerosol methods is discussed. A direct comparison of structural and chemical properties with sensing performance is given.
The American College of Rheumatology 1990 criteria for the classification of giant cell arteritis
Authors: Hunder Gene G. , Bloch Daniel A. , Michel Beat A. , Stevens Mary Betty , Arend William P. , Calabrese Leonard H. , Edworthy Steven M. , Fauci Anthony S. , Leavitt Randi Y. , Lie J. T. , Lightfoot Robert W. , Masi Alfonse T. , McShane Dennis J. , Mills John A. , Wallace Stanley L. , Zvaifler Nathan J. 
Published: August 2010

AbstractCriteria for the classification of giant cell (temporal) arteritis were developed by comparing 214 patients who had this disease with 593 patients with other forms of vasculitis. For the traditional format classification, 5 criteria were selected: age ≥50 years at disease onset, new onset of localized headache, temporal artery tenderness or decreased temporal artery pulse, elevated erythrocyte sedimentation rate (Westergren) ≥50 mm/hour, and biopsy sample including an artery, showing necrotizing arteritis, characterized by a predominance of mononuclear cell infiltrates or a granulomatous process with multinucleated giant cells. The presence of 3 or more of these 5 criteria was associated with a sensitivity of 93.5% and a specificity of 91.2%. A classification tree was also constructed using 6 criteria. These criteria were the same as for the traditional format, except that elevated erythrocyte sedimentation rate was excluded, and 2 other variables were included: scalp tenderness and claudication of the jaw or tongue or on deglutition. The classification tree was associated with a sensitivity of 95.3% and specificity of 90.7%.
The American College of Rheumatology 1990 criteria for the classification of takayasu arteritis
Authors: Arend William P. , Michel Beat A. , Bloch Daniel A. , Hunder Gene G. , Calabrese Leonard H. , Edworthy Steven M. , Fauci Anthony S. , Leavitt Randi Y. , Lie J. T. , Lightfoot Robert W. , Masi Alfonse T. , McShane Dennis J. , Mills John A. , Stevens Mary Betty , Wallace Stanley L. , Zvaifler Nathan J. 
Published: August 2010

AbstractCriteria for the classification of Takayasu arteritis were developed by comparing 63 patients who had this disease with 744 control patients with other forms of vasculitis. Six criteria were selected for the traditional format classification: onset at age ≤40 years, claudication of an extremity, decreased brachial artery pulse, >10 mm Hg difference in systolic blood pressure between arms, a bruit over the subclavian arteries or the aorta, and arteriographic evidence of narrowing or occlusion of the entire aorta, its primary branches, or large arteries in the proximal upper or lower extremities. The presence of 3 or more of these 6 criteria demonstrated a sensitivity of 90.5% and a specificity of 97.8%. A classification tree also was constructed with 5 of these 6 criteria, omitting claudication of an extremity. The classification tree demonstrated a sensitivity of 92.1% and a specificity of 97.0%.
Inhibition of Leukotriene B4 synthesis in neutrophils from patients with rheumatoid arthritis by a single oral dose of methotrexate
Authors: Sperling Richard I. , Coblyn Jonathan S. , Larkin John K. , Benincaso Anthony I. , Frank Austen K. , Weinblatt Michael E. 
Published: August 2010

AbstractWe studied the effects of a single, oral dose of methotrexate (MTX) on arachidonic acid metabolism in neutrophils from 6 patients with rheumatoid arthritis, which were obtained 1 day before and 1 day after their usual weekly MTX dose. The 6 patients had received a mean weekly MTX dose of 9.6 mg (range 5–15) for a mean of 61.7 months (range 58–64), and none received concomitant corticosteroids. Total generation of leukotriene B4 (LTB4) in neutrophils stimulated ex vivo with 10 μM calcium ionophore A23187 for 20 minutes was significantly suppressed, by a mean of 53%, after the MTX dose compared with the predose levels (mean ± SEM 13.0 ± 1.4 ng/106 cells versus 6.0 ± 0.9 ng/106 cells; P = 0.0019), reflecting a comparable suppression of both released and cell‐retained LTB4. A 49% decrease in ω‐oxidation products of LTB4 demonstrates that decreased LTB4 synthesis, rather than increased degradation, is responsible for the decrease in LTB4 generation. The absence of a significant change in either 3H‐labeled arachidonic acid release or platelet‐activating factor generation indicates that the observed decrease in LTB4 synthesis was apparently not caused by diminished phospholipase A2 activity. A 28% decrease in the total formation of the 5‐lipoxygenase products 5‐hydroxyeicosatetraenoic acid and the 6‐trans‐LTB4 diastereoisomers, and a 48% suppression of production of LTB4 plus its ω‐oxidation metabolites after the MTX dose suggest inhibition of 5‐lipoxygenase activity and possible suppression of leukotriene A4 epoxide hydrolase activity.
Enhanced prostaglandin E2 secretion by cytokine‐stimulated human synoviocytes in the presence of subtherapeutic concentrations of nonsteroidal antiinflammatory drugs
Authors: Lindsley Herbert B. , Smith Donald D. 
Published: August 2010

AbstractHuman synoviocytes were stimulated for 48 hours or 72 hours with cytokines (recombinant interleukin‐1β and/or recombinant tumor necrosis factor α) in the presence or absence of selected nonsteroidal antiinflammatory drugs. The drugs were tested at subtherapeutic and clinically therapeutic levels, as follows: piroxicam 0.3 pM to 3 × 106 pM, sodium salicylate 30 nM to 3 × 106 nM, and indomethacin 3 pM to 3 × 106 pM. At low concentrations, all 3 drugs showed significant enhancement of prostaglandin E2 (PGE2) secretion (piroxicam, salicylate > indomethacin). At high, clinically therapeutic concentrations, all drugs showed suppression of PGE2 secretion (indomethacin > piroxicam > salicylate). The enhancement of PGE2 secretion may be partially responsible for the flare of arthralgia or arthritis frequently seen after termination of drug therapy.
Low levels of interleukin‐4 and high levels of transforming growth factor β in rheumatoid synovitis
Authors: Miossec Pierre , Naviliat Mercedes , D'Angeac Arnaud Dupuy , Sany Jacques , Banchereau Jacques 
Published: August 2010

AbstractSince interleukin‐4 (IL‐4) displays agonistic effects on both T and B cells, we studied whether this lymphokine is involved in rheumatoid synovitis, a disease characterized by intense T cell infiltration and B cell stimulation. Rheumatoid arthritis synovial fluids (RA SF) contained no (<15 pg/ml) or very low amounts (<25 pg/ml) of IL‐4, as measured by a sensitive and specific enzyme‐linked immunosorbent assay. No IL‐4 was produced by unstimulated rheumatoid synovial membrane. RA SF were found to inhibit phorbol myristate acetate (PMA)‐dependent proliferation of normal peripheral blood lymphocytes (PBL). An inhibitory fraction with an apparent molecular weight of 150 kd was isolated by gel filtration. The inhibitory fraction strongly blocked the proliferation of PBL induced by PMA, PMA + IL‐2, or PMA + IL‐4. However, this fraction was less effective in blocking the proliferation of PBL induced by PMA + IL‐2 + IL‐4. High levels of transforming growth factor β (TGFβ) were found in these RA SF, and an anti‐TGFβ antibody was able to partially reduce the inhibitory activity. RA SF were found to inhibit phytohemagglutinin‐induced IL‐4 production by PBL. These data indicate that IL‐4, similar to other T cell lymphokines, cannot be detected in RA SF and that RA SF contains an inhibitory activity, related in part to TGFβ, which blocks mitogen‐induced proliferation of PBL, at least in part through an inhibition of T cell‐derived lymphokine release.
Serologic and molecular characterization of a human monoclonal rheumatoid factor derived from rheumatoid synovial cells
Authors: Robbins Dick L. , Kenny Thomas P. , Coloma Maria J. , Gavilondo‐Cowley Jorge V. , Soto‐Gil Rafael W. , Chen Pojen P. , Larrick James W. 
Published: August 2010

AbstractMolecular characterization of rheumatoid factors (RF) in rheumatoid arthritis (RA) has been hampered because of their polyclonality. To overcome this problem, we generated monoclonal RF‐secreting hybridomas from rheumatoid synovial cells. Among the RF‐secreting hybridomas, HAF10 secreted an IgM‐RF that was monospecific for human IgG. It bound well to IgG1 and IgG2, but not to IgG3 and IgG4. Sequence analysis of its heavy and light chains showed that it contained a VH1 heavy chain and a Vλ light chain that did not belong to any known λ light chain subgroup, and therefore, probably represented a new λ subgroup. These results indicated that both the heavy and light chains of a monoclonal IgM‐RF from rheumatoid synovial cells were quite different from the reported variable region sequences of several monoclonal RF derived mainly from patients with mixed cryoglobulinemia. Further studies of additional monoclonal RF from RA patients are warranted to define precisely their genetic basis and to further our understanding of the immunopathology of RA.
Association of autoantibodies to myeloperoxidase with different forms of vasculitis
Authors: Tervaert J. W. Cohen , Goldschmeding R. , Elema J. D. , Limburg P. C. , van der Giessen M. , Huitema M. G. , Koolen M. I. , Hené R. J. , The T. H. , van der Hem G. K. , von dem Borne A. E. G. Kr. , Kallenberg C. G. M. 
Published: August 2010

AbstractAntineutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase (MPO) were found in 53 patient sera that were routinely submitted for antineutrophil cytoplasmic antibody determination. Based on clinical and histologic criteria, 15 of these 53 patients were classified as having systemic necrotizing vasculitis of the polyarteritis group, 11 patients were classified as having Wegener's granulomatosis (WG), and 14 were classified as having idiopathic crescentic glomerulonephritis. The remaining 13 patients did not fulfill the diagnostic criteria for these disorders, although most of these patients had clinical symptoms compatible with these disorders. While all patients with WG had renal involvement, only 4 of the 15 patients with systemic necrotizing vasculitis of the polyarteritis group had glomerulonephritis. The sensitivity of autoantibodies to MPO for either systemic necrotizing vasculitis of the polyarteritis group, WG, or idiopathic crescentic glomerulonephritis was further tested in all our patients with these disorders (n = 104). Twenty‐seven of 104 patients had autoantibodies to MPO. Furthermore, 69 of the remaining 77 patients had autoantibodies specific for the 29‐kd serine protease, which has been reported to be specifically associated with WG. Sera from 8 patients were negative for either of these antibodies (92% sensitivity of autoantibodies to MPO and/or the 29‐kd serine protease). The specificity of autoantibodies to MPO for either systemic necrotizing vasculitis of the polyarteritis group, WG, or idiopathic crescentic glomerulonephritis was also tested in selected groups of patients who had closely related diseases. Two of 144 patients had autoantibodies to MPO (specificity 99%). We conclude that these antibodies are not only associated with idiopathic and vasculitis‐associated crescentic glomerulonephritis, but also with classic polyarteritis nodosa, Churg‐Strauss syndrome, and the polyangiitis overlap syndrome without renal involvement. The presence of autoantibodies to MPO or the 29‐kd serine protease is highly sensitive and specific for systemic necrotizing vasculitis of the polyarteritis group, WG, and idiopathic crescentic glomerulonephritis.
Immediate “steroid flare” from intraarticular triamcinolone hexacetonide injection: Case report and review of the literature
Authors: Berger Robert G. , Yount William J. 
Published: August 2010

AbstractWe describe a patient who had an immediate, intense, localized synovitis due to intraarticular triamcinolone hexacetonide injection. The reaction was secondary to rapid intracellular ingestion of the steroid microcrystals as demonstrated by compensated polarized microscopy. We report the unique nature of this patient's response, and we review previous literature regarding “steroid flare” after intraarticular injection.
The effect of diltiazem on calcinosis in a patient with the crest syndrome
Authors: Farah Maged J. , Palmieri Genaro M. A. , Sebes Jeno I. , Cremer Michael A. , Massie James D. , Pinals Robert S. 
Published: August 2010

AbstractWe describe a patient with a 23‐year history of progressive calcinosis and features of the CREST syndrome (calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, telangiectasias) who was treated with diltiazem, 240 mg/day, for 5 years. No clinical exacerbation of calcinosis occurred during treatment. Radiographs showed no new lesions, and there was reduction in the size of the existing lesions. Bone scans revealed a progressive decrease in the uptake of the radionuclide by soft tissue foci. We propose that diltiazem may stop the progression of calcinosis by reducing the cellular calcium influx in affected tissues.
Exploring the Limits of Frustrated Lewis Pair Chemistry with Alkynes: Detection of a System that Favors 1,1‐Carboboration over Cooperative 1,2‐P/B‐Addition
Authors: Chen Chao , Eweiner Florian , Wibbeling Birgit , Fröhlich Roland , Senda Shunsuke , Ohki Yasuhiro , Tatsumi Kazuyuki , Grimme Stefan , Kehr Gerald , Erker Gerhard 
Published: August 2010

AbstractThe zirconocene complex [{(C6F5)2B‐(CH2)3‐Cp}(Cp‐PtBu2)ZrCl2] (6; Cp=cyclo‐C5H4) was prepared by hydroboration of [(allyl‐Cp)(Cp‐PtBu2)ZrCl2] (5) with HB(C6F5)2 (“Piers’ borane”). It represents a frustrated Lewis pair (FLP) in which both the Lewis acid and the Lewis base were attached at the metallocene framework. Its reaction with 1‐pentyne did not result in the 1,2‐addition of or deprotonation reaction by the FLP, but rather in the 1,1‐carboboration of the triple bond, thereby obtaining a Z/E mixture (1.2:1) of the respective organometallic substituted alkenes 7. The analogous reaction of 1‐pentyne with the phosphorous‐free system [{(C6F5)2B‐(CH2)3‐Cp)}CpZrCl2] (9) gave the respective 1,1‐carboboration products (Z‐10/E‐10≈1.3:1).
Observer‐based finite‐time stabilization for extended Markov jump systems
Authors: Luan Xiaoli , Liu Fei , Shi Peng 
Published: August 2010

AbstractIn this paper, we study the problem of observer‐based finite‐time stabilization for a class of extended Markov jump systems with norm‐bounded uncertainties and external disturbances. The stochastic character under consideration is governed by a finite‐state Markov process, but with only partial information on the transition jump rates. Based on the finite‐time stability analysis, sufficient conditions for the existence of the observer‐based controller are derived via a linear matrix inequality approach such that the closed‐loop system trajectory stays within a prescribed bound in a fixed time interval. When these conditions are satisfied, the designed observer‐based controller gain matrices can be obtained by solving a convex optimization problem. Simulation results demonstrate the effectiveness of the approaches proposed in this paper.Copyright © 2010 John Wiley and Sons Asia Pte Ltd and Chinese Automatic Control Society
ChemInform Abstract: Synthesis and Crystal Structure of Cu3SbSe3.
Authors: PFITZNER A. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: High Ionic Conductivity of Solid Solutions of Lithium Sulfate in Hexagonal Sodium Sulfate Na2SO4 (I).
Authors: LUNDEN A. , NILSSON L. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electrocatalytic Reduction of Nitrite with Silicotungstic Heteropolyanion.
Authors: DONG S. , XI X. , TIAN M. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Formation of Fullerenes and Endohedral Metallofullerenes: Preparation in a Radiofrequency Furnace.
Authors: JANSEN M. , PETERS G. , WAGNER N. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: State and Crystal Structure of the Products of the Reaction of SiC with SiO2.
Authors: KHAENKO B. V. , PRILUTSKII E. V. , MIKHAILIK A. A. , KARPETS M. V. , KRAINIKOV A. V. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Crystal and Molecular Structure of Cesium Hexakis( fluorosulfato)antimonate(V) and Its Role in the HSO3F‐Sb(SO3F)5 Conjugate Superacid System.
Authors: ZHANG D. , RETTIG S. J. , TROTTER J. , AUBKE F. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Structural Characterization of Three New Compounds Containing (Nb6Cl12)2+ Units as Hydrated Hydroxides.
Authors: BRNICEVIC N. , PLANINIC P. , MCCARLEY R. E. , ANTOLIC S. , LUIC M. , KOJIC‐PRODIC B. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Structure of the Novel Diphosphate Rb(Ni0.35Cr0.3Ti0.35) P2O7. ‐ The new title diphosphate is prepared from NiO, Cr2
Authors: YAKUBOVICH O. V. , DIMITROVA O. V. , STRELKOVA E. E. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.