bluuebunny/crossref_metadata_2025_split huggingface dataset:
57: EVALUATION OF THE CIRCULATING LEVELS OF IL-12 AND IL-33 IN PATIENTS WITH BREAST CANCER: INFLUENCES OF THE TUMOR STAGES AND CYTOKINE GENE POLYMORPHISMS
Authors: Minaee Keyhan , Jafarzadeh Abdolahe , Rostami Maryam , Bonyani Mehdi , Eftekhari Moohamadhassan , Tabrizi Reza 
Published: May 2024

Background and aims:IL-12 as an anti-tumor cytokine and IL-33 a novel identified cytokine with both pro- or anti-tumor activities, play important roles in response against tumor cells. Our aim was to evaluate the IL-12 and IL-33 levels and single nucleotide polymorphisms (SNP) in their genes in patients with breast cancer.Methods:Blood samples were collected from 100 patients with breast cancer, and 100 healthy women were controls. The serum IL-12 and IL-33 levels were measured by ELISA. The SNP rs3212227 (in IL-12 gene) and rs1929992 (in IL-33 gene) were determined using PCR-RFLP.Results:The IL-12 levels similarly expressed in patients and controls. IL-12 levels in patients at stage I were significantly lower than in the healthy group (P<0.05). IL-33 levels and the IL-33/IL-12 ratio were significantly higher in patients than the control group (P<0.001). The IL-33 levels and IL-33/IL-12 ratio in stage IV patients were significantly higher than other stages and controls (PP<0.001, respectively). There were no significant differences in the frequencies of genotypes in rs3212227 and rs1929992 between patients and the control group. No significant differences were observed between subjects with various genotypes at rs3212227 and rs1929992 with respect to related cytokine levels.Conclusion:These results indicate that the diminished IL-12 production may contribute to the tumor establishment. The higher IL-33 levels and IL-33/IL-12 ratio in patients also indicate an imbalance in Th1/Th2 responses that may contribute to tumor development. Thus, correcting the imbalance of Th1/Th2 could be an important strategy for cancer immunotherapy.
66: EXPLORING THE APPLICATION OF EVIDENCE IN THE IRANIAN NURSES' CLINICAL JUDGMENT AND DECISION MAKING: A HYBRID QUALITATIVE STUDY
Authors: Seidi Jamal , Alhani Fatemah , Salsali Mahvash , Kazemnejad Anoushirvan 
Published: May 2024

Background and aims:Clinical judgment is based on data collection, information, interpretation, and deduction due to clinical decision making for election of kind/place and time for an intervention or priority. This process needs to apply appropriate evidences; so this study was conducted in order to explain how to use the evidence of Iranian Nurses' Clinical Judgment and Decision Making.Methods:This Qualitative Study was a hybrid content and concept analysis. This study was a part of a research project approved by the National Institute of Health Research that was conducted at Kurdistan University of medical sciences in 2015. Based on purposive sampling, 26 open and semi structure interviews were conducted with 18 participants. Data collection simultaneously analyzing was continued till saturation and emerging themes. In the concept analyzing, literatures including, 12 articles, 2 books, and 1thesis were selected. Then these literatures were reviewed based on thematic analyzing,Results:Results of content analysis showed two main themes including; integration of the type of evidence based on situational of practice (for example guidelines in emergency ward) and how to access evidence (for example access by internet). Results of content analysis showed two factors determining the level of evidence used, including normal or urgent clinical conditions, having enough time.Conclusion:Combined results showed that integrating evidence in clinical judgment and decision making were based on access to evidence; clinical conditions, and time. Guidelines are the best integrated evidence in emergency wards and critical condition. When the guidelines were not available or there was insufficient time, nurses used their own experiences or the expert opinion. Therefore, it is recommended to update the guidelines and localize them for having appropriate integration of evidence.
8: ACADEMIC SELF-EFFICACY AND TEST ANXIETY AMONG STUDENTS OF MEDICAL SCIENCES
Authors: Taheri-Kharameh Zahra 
Published: May 2024

Background and aims:A student's level of self-efficacy and test anxiety directly impacts their academic performance. The aim of study was to determine the relationship between academic self-efficacy and test anxiety among the students of the Qom medical sciences university.Methods:In this descriptive and analytical study, 100 students of the Qom University of Medical Sciences were selected via random sampling methods. The students completed the test anxiety and academic self-efficacy Questionnaires. Logistic regression analysis and Pearson correlation coefficient were used for data analysis.Results:The score of test anxiety of 48.2% of the students was more than the mean of test anxiety score. Results showed a negative and significant relationship between academic self-efficacy and test anxiety (r=0.21;p=0.04). Multivariate logistic regression analysis showed self-efficacy predicts the test anxiety (OR=0.34, % 95 CI: 0.16–0.74).Conclusion:The findings of this study showed that the students with higher self-efficacy experience lower test anxiety. Therefore, the strengthening of this individual feature in students can lead to the better performance of students in the exam situation by decreasing of test anxiety
88: MANAGER'S PERSONALITY TYPE: DOES IT MAKE DIFFERENCE IN THE APPLICATION OF EVIDENCE-BASED PRACTICE APPROACH
Authors: Sokhanvar Mobin , Naderi Bahar , Kakemam Edris , Arab-Zozani Morteza , Mousazadeh Yalda 
Published: May 2024

Background and aims:Managers are responsible for their decisions and organizational performance. Evidence-based practice (EBP) can improve decision effectiveness and secure organization against potential risks. This study was conducted to investigate the relationship between managers personality type and using evidence- based practice approach.Methods:This descriptive-analytical study was done in 2015 among managers of Tehran teaching hospitals. Census method was used to sampling and all hospital managers (44 managers) were selected. Standard DISC personality test and researcher-designed questionnaire (about using EBP approach) were used for data collection. Data analyzes were performed through SPSS-V20 software by using One-Way ANOVA and Tukey statistical tests.Results:The response rate was 86.4 percent. The 81.6 percent of managers were men and mean age of all participates was 46.7 years. The 57.8 percent of managers had academic education in management. Findings showed that the portion of dominant, influential, steady and conscientious personality types were 36.4, 27.3, 13.6, and 22.7 percent, respectively. The mean of using EBP approach was 3.1 of five point scale. The results of One-Way ANOVA showed that the scores of EBP using were different based on personality types (p<0.05). The Tukey's results determined that the mentioned difference was related to conscientious personality type.Conclusion:Managers with conscientious personality type had used EBP approach more than others. Therefore, it can be suggested to conduct similar studies in larger samples and using the results of these studies in recruiting processes particularly for key jobs.
91: NARRATIVE REVIEW OF WOMEN'S HEALTH IN IRAN: CHALLENGES AND SUCCESSES
Authors: Akbari Maryam , Joulaei Hasan 
Published: May 2024

Background and aims:In each society, the health of women in different periods may be endangered by an unequal distribution of resources, facilities, and gender prejudices. The present study evaluated the time trend of Iranian women's health between 1990 and 2013.Methods:This narrative review includes an integration and descriptive summary of the existing evidence on trends and criteria of different aspects of women's health from social determinant point of view. The evidence was drawn from peer-reviewed, cross-national or large-scale studies, official sources of the Ministry of Health, reviews, and online scientific databases published between 1990 and 2013.Results:The average life expectancy of Iranian women has increased from 44.15 years in 1960 to 75.75 years in 2012; in most deprived provinces of Iran, however, this criterion is about 67.3 years, and in the capital it is 75.8 years. In 2011, 43.37% of DALYS, 36.21% of YLL, and 1.92% of YLD were dedicated to women; these figures were 3.63% lower than they were in 2003. Although a significant reduction has occurred in maternal mortality rate, which dropped from 83 to 23 per 100,000 between 1990 and 2013, there is no equal distribution in maternal mortality across the country as manifested by the unfavorable conditions of border provinces (SD=19.2). The prevalence of HIV/AIDS is an alarming health problem among Iranian females, increasing approximately 546% between 2007 and 2015. As for mental health, depression in women was ranked first among diseases in 2011 compared to a second place ranking in 2003. As regards social health, the delinquency of women has increased in recent years compared to men with women committing more crimes related to drugs and actions against virtue. The annual report of the United Nations for the gender gap index in 2013 ranked Iran as 130 among 136 countries (from 0.622 in 2000 to 0.584 in 2013).Conclusion:Generally, over the last three decades, the health indices of Iranian women have grown in aspects of physical, mental, and social health. Remarkable differences can be seen among female health indices based on geographic location and in comparison with men. To promote an improved health status for Iranian women, the root causes of the discrepancies must be identified and a comprehensive national plan must be established.
Scoping review of exposure questionnaires and surveys in interstitial lung disease
Authors: Barnes Hayley , Elmrayed Seham , Barber Christopher Michael , Feary Johanna , Lee Cathryn T , Gandhi Sheiphali , Peters Cheryl E , Salisbury Margaret L , Johannson Kerri A 
Published: May 2024

BackgroundMany interstitial lung diseases (ILDs) have clear causal relationships with environmental and occupational exposures. Exposure identification can assist with diagnosis, understanding disease pathogenesis, prognostication and prevention of disease progression and occurrence in others at risk. Despite the importance of exposure identification in ILD, there is no standardised assessment approach. Many questionnaires are in clinical and research use, yet their utility, applicability, relevance and performance characteristics are unknown.ObjectivesThis scoping review aimed to summarise the available evidence relating to ILD exposure assessment questionnaires, identify research gaps and inform the content for a future single evidence-based ILD questionnaire.MethodsA scoping review based on Arksey and O’Malley’s methodological framework was conducted. Eligibility criteria: Any questionnaire that elicited exposures specific to ILD was included. A modified COSMIN Risk of Bias Framework was used to assess quality. Sources of evidence: Relevant articles were identified from MEDLINE and EMBASE up to 23 July 2023.Results22 exposure questionnaires were identified, including 15 generally pertaining to ILD, along with several disease-specific questionnaires for hypersensitivity pneumonitis (n=4), chronic beryllium disease, sarcoidosis and silicosis (1 questionnaire each). For most questionnaires, quality was low, whereby the methods used to determine exposure inclusion and questionnaire validation were not reported or not performed. Collectively the questionnaires covered 158 unique exposures and at-risk occupations, most commonly birds, mould/water damage, wood dust, asbestos, farming, automotive mechanic and miners. Only five questionnaires also provided free-text fields, and 13 queried qualifiers such as temporality or respiratory protection.ConclusionsDesigning a robust ILD-specific questionnaire should include an evidence-based and relevance-based approach to exposure derivation, with clinicians and patients involved in its development and tested to ensure relevance and feasibility.
13 What works, for whom and in which circumstances when implementing the namaste advanced dementia care programme in the home setting?
Authors: Dalkin Sonia Michelle , Lhussier Monique , Atkinson Joanne , Kendall Nicola , Tolman Sharron 
Published: May 2024

IntroductionThe Namaste Advanced Demntia Care Programme is a holistic, novel approach based on the five senses, aimed at evoking an emotional response and providing positive ways of communicating with those who have advanced dementia (www.namastecare.com). Namaste has been utilised in care homes internationally (Simard and Volicer, 2010) yet use in the home setting has been scarce. A hospice in the North East of England has implemented Namaste in peoples’ homes through training and matching volunteers to families.AimTo begin to understand what works, for whom and in which circumstances when implementing Namaste Care in the home setting.MethodsA realist evaluation framework was utilised to develop initial programme theories about the use of Namaste in the home setting (Pawson and Tilley, 1997). The theories were developed through three realist focus groups with Namaste volunteers. Data was analysed using context-mechanism-outcome configurations (CMOC). The theories detail if, how and under which circumstances the Namaste Programme works.ResultsFour initial programme theories were developed which were focused around (1) the impact on the person (2) the use of Namaste in the home setting (3) family’s independent use of Namaste (4) the relationships between the person with dementia, the volunteer and the family.ConclusionDe-hospitalisation is a current policy driver (Foot et al., 2014); this public health approach works towards creating a community of care through engaging the family and community volunteers. The programme theories developed can now be tested in a larger scale study to further demonstrate the impact of Namaste in the home setting.References. Foot C, Sonola L, Bennett L, Fitzsimons B, Raleigh V, Gregory S. Managing quality in community health care services.The King’s Fund2014.. Pawson R, Tilley N.Realistic Evaluation,London Sage.. Simard J, Volicer L. Effects of Namaste Care on Residents Who Do Not Benefit From Usual Activities.American Journal of Alzheimer’s Disease & Other Dementias2010;25:46–50.
29 Working with dying men in a group setting
Authors: Kravitz Peter 
Published: May 2024

This workshop explores working with long-term men’s groups. It will examine the breadth of topics involved and describe the range of skills required by the facilitators.‘My pain has stabilised – I now have to find a way of living again.’This presentation follows someone who has always thought of themselves as the hero becoming the one who is being looked after. However gradual this transition may be, to the person experiencing it, it can seem so sudden as to be shocking.‘In the group anything can come up. It’s people sharing experiences, good or bad, funny or sad. It’s a type of conversation that is hard to get elsewhere.’These are typical words from one member of the weekly Men’s Group. This presentation will consider what happens when patients with an advanced cancer diagnosis begin to meet regularly in a facilitated single gender setting.What are the ways back to finding meaning when your life is significantly abbreviated? Shifts occur and this can be challenging to follow in facilitation.Conversation topics amongst men such as current affairs and sport flow into comparisons of how each person’s pain is treated. A dominant theme is fear of loss of control. Indeed, such issues inevitably arise between group members as well. This may provoke reaction, where a response is what is required.What happens within the envelope of confidentiality of the group is surprising. In the privacy of a regular group, men here show that courage is a lot more than a wall-off-fear-and-battle-on approach.
32 Improving patient and public involvement in end of life care research
Authors: Seddon Kathy , Murray Alexandra , Buckle Peter 
Published: May 2024

IntroductionMembers of the Marie Curie (MC) Expert Voices Group (EVG) have all cared for someone at the end of life. Research EVG (REVG) members use this experience to contribute to research. To improve Patient and Public Involvement (PPI) in end of life research they used motivation theory to review case studies of their contributionsAim(s)To improve the quality of PPI in end of life care (EOLC) research through consideration of motivation, using REVG case studies.Method(s)Review case studies of REVG involvement in EOLC research.Note factors contributing to participant sense of efficacy.Explore alignment with participant professed reasons for contributing to research thus draw together key factors promoting successful PPI.ResultsCase Studies of REVG involvement at all stages of research cycles included:• Reviewing research submissions e.g. Research Centre QQR• Questionnaire design and wording e.g. Delphi study on advance care planning• Consensus days e.g. Bereavement consensus days• Dissemination e.g. Presentations to government. Brain Tumour information sheet• Impact e.g. Use of case studies for review publicationsFactors found to contribute to participant sense of efficacy in these examples included:• Targeted informative invitations• Clear jargon free instructions• Good facilitation drawing out participant experiencesEnsuring alignment with participant’s reasons for action included:• Opportunities to use all expertise• Understanding the range of participant goals and planning to allow them to be metConclusion(s)PPI may be more effective if participant motivational needs are understood and planned for.References. Bandura, A. (1993). Perceived self-efficacy in cognitive development and functioning. Educational Psychologist, 28, 117–148.. Csikszentmihalyi, M. (1997b). Finding flow. New York: Basic Books.. de Charms, R. (1976). Enhancing motivation. New York: Irvington.. Deci, E. L. (1980). The psychology of self-determination. Lexington MA: D. C. Heath.. Maslow, A. H. (1968). Towards a psychology of being. New York: Van Nostrand-Rheinhold.. Yin, R. (1994). Case study research: Design and methods (2nd edn.). Thousand Oaks, CA: Sage Publishing.
44 Marie curie echo network: an innovative practice development initiative
Authors: Cassidy Lyndsay , Heneghan Paula , O’Kane Eamon 
Published: May 2024

IntroductionPalliative care is increasingly delivered in the community by health care assistants caring for people in their own homes. To ensure these lone workers are well supported and have access to evidence based education is crucial. Due to the geographical challenges, Marie Curie considered novel ways in which we could reach these workers better.Marie Curie in Northern Ireland successfully submitted a bid to be part of Project Echo NI. Project Echo is a telementoring programme which uses video-conferencing and is led in Northern Ireland by Northern Ireland Hospice.AimThis model aimed to enable community based health care assistants to access education, and increase their knowledge and confidence in caring for people living with a terminal illness.MethodsProject Echo uses a hub and spoke model, with members of a multi-disciplinary team being at the hub and participants logging in from around Northern Ireland (spokes). Participants generate the topics that they wish to cover in the programme. Evaluation data was collected at 6 time points throughout the programme.ResultsComplete evaluation data will be presented. Positive evaluation results around the technology and method of learning demonstrate how this could be replicated in other areas around the country. Peer learning and access to the multi-disciplinary team were all seen as key in making the programme effective.ConclusionsProject Echo is an internationally recognised programme, which has been used effectively to deliver a person centred approach to practice development. Marie Curie is now considering other uses for this technology.References. Devlin, M. & Mcilfatrick, S. 2010. Providing Palliative and End-of-Life Care in the Community: The Role of the Home Care Worker.International Journal of Palliative Care,16(4), 195–203.. Herber, O. R. & Johnston, B. M. 2013. The Role of Healthcare Support Workers in Providing Palliative and End-of-Life Care in the Community: A Systematic Literature Review. Health & Social Care in the Community, 21(3), 225–235.
47 The wow consultation
Authors: Laidlaw Sheonad , Carduff Emma 
Published: May 2024

Marie Curie Care are in the final stages of implementing an Electronic Patient Records (EPR) and Patient Administration System (PAS), via EmisWeb, enabling the recording of real time patient data on the ward by means of Workstations on Wheels (WOWS). It is hoped that the WOWs will be used at the bedside but health care professionals (HCP) are concerned that this will affect the patient centred care that is the cornerstone of Palliative Care.Computers are common place in general practice. Studies by Pearce et al (2011, 2008) have been conducted looking at the relationship and interaction between doctor, patient and computer – the third party in the consultation – and show that the doctor-patient relationship changes as each relates to the computer. No research has looked at this relationship in palliative care.A qualitative study was conducted at the Glasgow hospice using a questionnaire exploring the staff’s feelings about using the WOW in a consultation; their perception of how the patient and their family would feel; how they think that the computer will affect the consultation; and the positives and negatives of using a computer with their patients.Results show that staff are hesitant and nervous of using WOWs by the bedside, seeing it as a physical barrier to verbal and non-verbal communication, potentially impeding the rapport – and ultimately the relationship - between HCP and patient. Staff see the benefit of using computers to capture patient centred data but not at the expense of their relationship with the patient.References. Pearce, C, et al. (2011) “The patient and the computer in the primary care consultation”J Am Med Inform Assoc18 (2): 138–142. Pearce, C, et al. (2008) “Computers in the new consultation: within the first minute”Fam Pract2008 Jun; 25 (3): 202–8