bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parenting of 7‐month‐old infants at familial risk for attention deficit/hyperactivity disorder
Authors: Landau Rivka , Avital Miri , Berger Andrea , Atzaba‐Poria Naama , Arbelle Shoshana , Faroy Michal , Auerbach Judith G. 
Published: March 2010

AbstractPatterns of interaction between parents and 7‐month‐old boys at familial risk for attention deficit/hyperactivity disorder (ADHD) and a comparison group were studied during a warm‐up and two play episodes. The sample included 78 (47 at‐risk, 31 comparison) mother–child and 45 (27 at‐risk, 18 comparison) father–child dyads. A coding system developed by G. Kochanska (1997, 1998) was used. Infants in the risk group did not differ from the comparison group in the rate of emission of infant‐related events. However, they received less adequate responsivity from both their fathers and their mothers to these events, and specifically to negative emotions or distress, than did the comparison group. Maternal psychopathology did not account for these findings. Mothers were more adequately responsive than were fathers, especially for physiological needs. The association between nonoptimal interaction in infancy and the development of ADHD is discussed.
Adaptation of a behavioral parent‐training curriculum for Hispanic caregivers: HOT DOCS Español
Authors: Agazzi Heather , Salinas Abraham , Williams Jillian , Chiriboga Daniela , Ortiz Cristina , Armstrong Kathleen 
Published: March 2010

AbstractThis article presents the process utilized to adapt a behavioral parent‐training curriculum for Hispanic caregivers from a program currently available in English. Throughout this process, a number of cultural and language elements were identified as needing to be modified to meet the needs of the Hispanic population served. Fidelity and fit were balanced to develop a curriculum acceptable to diverse Hispanic caregivers while also incorporating all the essential elements of a theory‐based approach to training caregivers. The lessons learned from this adaptation may assist others in their attempts to meet the needs of Hispanic families.
A caregiver–child socioemotional and relationship rating scale
Authors: McCall Robert B. , Groark Christina J. , Fish Larry 
Published: March 2010

AbstractThis article reports the construction and pilot reliability, validity, and psychometric properties of a new caregiver–child rating scale that emphasizes caregiver–child socioemotional interactions and relationships. While the scale was developed and studied in orphanages for young children, it potentially could be used in nonresidential early care and education settings as well as for parent–child interactions in the home. The intent was to assess a few dimensions that comprehensively cover the range of caregiver–child socioemotional interactions and relationships, by means of a scale that could be administered in a relatively short time period in a variety of situations and would not require extensive coder training, manuals, or materials. Results showed that the scale can be reliably administered even using observation periods as short as 5 min, that inter‐rater reliability was acceptable (based on data from two raters working in two orphanages, and five raters working in another), and that ratings of caregivers were similar across different types of caregiving activities (i.e., feeding, dressing/bathing, free play) and for caregivers attending to children birth to 4 and 4 to 8 years of age. In the orphanage context, factor analyses showed that the scale primarily reflects caregiver–child mutual engagement and relationship with subordinate components of caregiver punitiveness and caregiver‐ versus child‐directed behaviors and intrusiveness.
The child as held in the mind of the mother: The influence of prenatal maternal representations on parenting behaviors
Authors: Dayton Carolyn Joy , Levendosky Alytia A. , Davidson William S. , Bogat G. Anne 
Published: March 2010

AbstractUsing a longitudinal design, this study examined the relationship of a mother's prenatal representation of her child and her parenting behavior with that child at 1 year of age in a sample of women who were either exposed or not exposed to intimate partner violence (IPV) (N = 164; M child age = 1.1 years, SD = .11 years; 52% male). Controlling for prenatal IPV, a MANCOVA analysis revealed that prenatal representational typology was significantly related to parenting behavior 1 year postpartum. Mothers whose representations were affectively deactivated (disengaged) were more behaviorally controlling with their children. Mothers whose representations were affectively overactivated (distorted) were more hostile with their children. Mothers with balanced representations demonstrated more positive parenting. Exposure to IPV did not moderate this relationship. There was no direct association between prenatal or postnatal IPV and parenting behavior. These findings suggest that prenatal representations influence postnatal parenting behavior in significant and theoretically consistent ways and that this relationship functions similarly for both abused and nonabused women. Results add to the growing literature that internal representations serve to guide behavior throughout development and suggest that maternal working models may be one important link in the intergenerational transmission of attachment relationships.
Phenomenology, psychopathology, and short‐term therapeutic outcome of 102 infants aged 0 to 12 months consecutively referred to a community‐based 0 to 3 mental health clinic
Authors: Viaux‐Savelon Sylvie , Rabain Didier , Aidane Elisabeth , Bonnet Philippe , Montes de Oca Marcella , Camon‐Sénéchal Laurence , David Michéle , Couëtoux Francine , Wendland Jaqueline , Gérardin Priscille , Mazet Philippe , Guedeney Antoine , Keren Miri , Cohen David 
Published: March 2010

AbstractInfants ages 0 to 1 year consecutively referred for psychiatric treatment during the year 2005 were followed, and variables associated with diagnosis and short‐term outcome were assessed. Infants were evaluated using the Psychiatric Infant Navigator Chart and Evaluation that includes nosological diagnoses [Diagnostic Classification of Mental Health and Developmental Disorders of Infancy and Early Childhood, (DC 0–3), Zero to Three, 1994] as well as risk and protective factors, treatment procedure, and outcomes. Seventy‐six percent of the infants had an Axis I diagnosis, with anxiety disorders and a mixed disorder of emotional expressiveness being the most frequent. Twenty‐five percent had an Axis II diagnosis. Multiple correspondence analyses showed that two dimensions corresponding grossly to DC 0–3 Axes I and II emerged. They emphasized three clinical profiles characterized by (a) good infant functioning, parent's awareness of their own difficulties, and a good outcome; (b) moderate child symptoms, overinvolved relating, and a good/intermediate outcome; (c) severe child symptoms, underinvolved relating, and a less favorable short‐term outcome, signaling the risk for developmental disorders. Among the associated risk factors were cumulative parental stress, maternal psychopathology, and family dysfunction. Clinical implications of these findings indicated that infants under the age of 1 year who are referred for mental health evaluation and intervention are a heterogeneous group in terms of both severity and prognosis. Clinicians should differentiate subgroups of young children to detect those infants at risk for persistent psychopathology.
Oligomeric alpha‐synuclein and its role in neuronal death
Authors: Brown David R. 
Published: March 2010

AbstractAlpha‐synuclein is a natively unfolded protein associated with a number of neurodegenerative disorders that include Parkinson's disease. In the past, research has focused on the fibrillar form of the protein. Current research now indicates that oligomeric alpha‐synuclein is the form of the protein most likely to causes neuronal death. Recent research has suggested that a unique oligomer associated with the copper binding capacity of the protein is the neurotoxic form of the protein. This review looks at the evidence for this possibility. © 2010 IUBMB IUBMB Life, 62(5): 334–339, 2010
Competition in large markets
Authors: Campbell Jeffrey R. 
Published: March 2010

AbstractThis paper evaluates the simplifying assumption that producers compete in a large market without substantial strategic interactions using nonparametric regressions of producers' choices on market size. With such atomistic competition, increasing the number of consumers leaves the distributions of producers' prices and other choices unchanged. In many models featuring non‐trivial strategic considerations, producers' prices fall as their numbers increase. I examine observations of restaurants' sales, seating capacities, exit decisions, and prices from 222 US cities. Given factor prices and demographic variables, increasing a city's size increases restaurants' average sales and decreases their exit rate and prices. These results suggest that strategic considerations lie at the heart of restaurant pricing and turnover. Copyright © 2010 John Wiley & Sons, Ltd.
High‐resolution tomographic diffractive microscopy of biological samples
Authors: Simon Bertrand , Debailleul Matthieu , Beghin Anne , Tourneur Yves , Haeberlé Olivier 
Published: March 2010

AbstractThe authors have developed a tomographic diffractive microscope that combines microholography with illumination from an angular synthetic aperture. It images specimens relative to their complex index of refraction distribution (index and absorption) and permits imaging of unlabelled specimens, with high lateral resolution. The authors now study its use for biological applications, and imaged several preparations with fluorescence confocal microscopy and tomographic diffractive microscopy. The results highlight some interesting features of this instrument, which should attract the interest of biologists for this new technique. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
How neighborhoods matter for rural and urban children's language and cognitive development at kindergarten and Grade 4
Authors: Lloyd Jennifer E.V. , Hertzman Clyde 
Published: March 2010

AbstractThe authors took a population‐based approach to testing how commonly studied neighborhood socioeconomic conditions are associated with the language and cognitive outcomes of residentially stable rural and urban children tracked from kindergarten (ages 5–6) to Grade 4 (ages 9–10). Child‐level kindergarten Early Development Instrument (EDI) data were probabilistically linked to scores on Grade 4's Foundation Skills Assessment (FSA), 4 years later, and to socioeconomic data describing the children's residential neighborhoods. Multilevel analyses were performed for a study population of 5,022 children residing in 105 neighborhoods across British Columbia, Canada: 635 children in 20 rural neighborhoods and 4,825 children in 85 urban neighborhoods. Concentrated immigration consistently predicted better child outcomes. Moreover, the determinants of children's language and cognitive outcomes analyzed cross‐sectionally differed from the determinants of outcomes analyzed longitudinally. Furthermore, there were notable differences in the extent of the relationship between neighborhood socioeconomic conditions and rural and urban children's outcomes over time. © 2010 Wiley Periodicals, Inc.
Social capital, safety concerns, parenting, and early adolescents' antisocial behavior
Authors: Vieno Alessio , Nation Maury , Perkins Douglas D. , Pastore Massimiliano , Santinello Massimo 
Published: March 2010

AbstractThis study explores the relations between neighborhood social capital (neighbor support and social climate), safety concerns (fear of crime and concern for one's child), parenting (solicitation and support), and adolescent antisocial behavior in a sample of 952 parents (742 mothers) and 588 boys and 559 girls from five middle schools (sixth through eighth grades) in a midsize Italian city. In structural equation models, social capital is strongly and inversely related to safety concerns and positively related to parental support and solicitation. In turn, safety concerns are also positively related to parental support and solicitation. Social capital and safety concerns have indirect effects on children's antisocial behavior through their effects on parenting. Implications are discussed for parenting and community‐based interventions to prevent or reduce youth antisocial behaviors. © 2010 Wiley Periodicals, Inc.
Participation in boys and girls clubs: motivation and stage environment fit
Authors: Fredricks Jennifer A. , Hackett Kristen , Bregman Allyson 
Published: March 2010

AbstractThis article presents the results of semi‐structured in‐depth interviews conducted with 54 youth attending six elementary school‐based and middle school‐based Boys and Girls Clubs in two low‐income communities. The first goal of this study was to examine why youth choose to participate in these clubs. The most commonly reported motives include fun activities, opportunities to be with friends, parent has to work, and getting help with homework. The second goal was to examine youths' perceptions of staff, peers, activities, and the extent to which clubs are organized in a way to support the need for relatedness, competence, and autonomy. Variations in youths' perceptions of the quality of relationships with staff and peers, level of interest and challenge, and opportunities for decision making, by developmental level (elementary versus middle school) are discussed. Implications of our findings for sustaining youths' interest and continued involvement in out‐of‐school youth development programs are highlighted. © 2010 Wiley Periodicals, Inc.
African American high school students and variability in behavior across classrooms
Authors: Gregory Anne , Thompson Aisha R. 
Published: March 2010

AbstractMany African American adolescents who enter high school with low achievement are at‐risk for being perceived as defiant and uncooperative by their classroom teachers. This generalized view of risk, however, offers little understanding of the differentiated behavior these students have with their teachers. The study followed 35 African American students, who have a history of low achievement, across multiple classrooms in their school day. Hierarchical linear modeling showed that there was greater variability in teacher‐perceived defiance, cooperation, and office discipline referrals “within‐student” compared with “between‐students.” This shows that individual students tended to be perceived differently across their teachers. Similarly, the study found that students also tended to differentiate their teachers. Students who reported unfair treatment with a particular teacher were more likely to receive a discipline referral and be perceived as defiant and uncooperative by that teacher. Implications for a strengths‐based approach to classroom behavior are discussed. © 2010 Wiley Periodicals, Inc.
The relation of perceived and received social support to mental health among first responders: a meta‐analytic review
Authors: Prati Gabriele , Pietrantoni Luca 
Published: March 2010

AbstractThere are plenty of theories that may support the protective role of social support in the aftermath of potentially traumatic events. This meta‐analytic review examined the role of received and perceived social support in promoting mental health among first responders (e.g., firefighters, police officers, and paramedics or emergency medical services personnel). Results showed that the effect sizes derived from 37 empirical studies ranged from 0 to 0.46. The overall weighted mean effect size was of medium magnitude (r=0.27). Moreover, moderator analysis showed that the effect size of perceived social support (r=0.31) was significantly higher than the effect size of received social support (r=0.22). Participants' age and gender or research design did not exert an influence on the relationship between social support and mental health. Theoretical implications and limitations are discussed. © 2010 Wiley Periodicals, Inc.
Functional aspects of factor VIII expression after transplantation of genetically‐modified hematopoietic stem cells for hemophilia A
Authors: Ide Lucienne M. , Iwakoshi Neal N. , Gangadharan Bagirath , Jobe Shawn , Moot Robert , McCarty David , Doering Christopher B. , Spencer H. Trent 
Published: March 2010

AbstractBackgroundMajor complications with respect to the development of gene therapy treatments for hemophilia A include low factor VIII (fVIII) expression and humoral immune responses resulting in inhibitory anti‐fVIII antibodies. We previously achieved sustained curative fVIII activity levels in hemophilia A mice after nonmyeloablative transplantation of genetically‐modified hematopoietic stem cells (HSCs) encoding a B‐domain deleted porcine fVIII (BDDpfVIII) transgene with no evidence of an immune response.MethodsMouse HSCs were transduced using MSCV‐based recombinant virus encoding BDDpfVIII and transplanted into hemophilia A mice. Transplanted mice were followed for donor cell engraftment, fVIII expression and activity, and generation of anti‐fVIII immune response.ResultsWe now show that: (i) the protein expressed by hematopoietic cells has a specific activity similar to that of purified protein; (ii) BDDpfVIII expressed from hematopoietic cells effectively induces thrombus formation, which is shown using a new method of in vivo analysis of fVIII function; (iii) naïve and pre‐immunized mice receiving HSC gene therapy are nonresponsive to challenges with recombinant human fVIII; (iv) nonresponsiveness is not broken after stringent challenges with BDDpfVIII; and (v) T cells from these mice are unresponsive to BDDpfVIII presentation. Furthermore, stem cells isolated from donors with high titer anti‐human fVIII antibodies show no defects in donor cell engraftment or the ability to express BDDpfVIII.ConclusionsThese results demonstrate that HSC gene therapy can be an effective alternative treatment for individuals with hemophilia A and may benefit patients by inducing immunological nonresponsiveness to fVIII replacement products. Copyright © 2010 John Wiley & Sons, Ltd.
Interaction of neurotrophin signaling with Bcl‐2 localized to the mitochondria and endoplasmic reticulum on spiral ganglion neuron survival and neurite growth
Authors: Renton John P. , Xu Ningyong , Clark J. Jason , Hansen Marlan R. 
Published: March 2010

AbstractEnhanced spiral ganglion neuron (SGN) survival and regeneration of peripheral axons following deafness will likely enhance the efficacy of cochlear implants. Overexpression of Bcl‐2 prevents SGN death but inhibits neurite growth. Here we assessed the consequences of Bcl‐2 targeted to either the mitochondria (GFP‐Bcl‐2‐Maob) or the endoplasmic reticulum (ER, GFP‐Bcl‐2‐Cb5) on cultured SGN survival and neurite growth. Transfection of wild‐type GFP‐Bcl‐2, GFP‐Bcl‐2‐Cb5, or GFP‐Bcl‐2‐Maob increased SGN survival, with GFP‐Bcl‐2‐Cb5 providing the most robust response. Paradoxically, expression of GFP‐Bcl‐2‐Maob results in SGN death in the presence of neurotrophin‐3 (NT‐3) and brain‐derived neurotrophic factor (BDNF), neurotrophins that independently promote SGN survival via Trk receptors. This loss of SGNs is associated with cleavage of caspase 3 and appears to be specific for neurotrophin signaling, insofar as coexpression of constitutively active mitogen‐activated kinase kinase (MEKΔEE) or phosphatidyl inositol‐3 kinase (P110), but not other prosurvival stimuli (e.g., membrane depolarization), also results in the loss of SGNs expressing GFP‐Bcl‐2‐Maob. MEKΔEE and P110 promote SGN survival, whereas P110 promotes neurite growth to a greater extent than NT‐3 or MEKΔEE. However, wild‐type GFP‐Bcl‐2, GFP‐Bcl‐2‐Cb5, and GFP‐Bcl‐2‐Maob inhibit neurite growth even in the presence of neurotrophins, MEKΔEE, or P110. Historically, Bcl‐2 has been thought to act primarily at the mitochondria to prevent neuronal apoptosis. Nevertheless, our data show that Bcl‐2 targeted to the ER is more effective at rescuing SGNs in the absence of trophic factors. Additionally, Bcl‐2 targeted to the mitochondria results in SGN death in the presence of neurotrophins. © 2010 Wiley‐Liss, Inc.
Meta‐analysis of a binary outcome using individual participant data and aggregate data
Authors: Riley Richard D. , Steyerberg Ewout W. 
Published: March 2010

AbstractIn this paper, we develop meta‐analysis models that synthesize a binary outcome from health‐care studies while accounting for participant‐level covariates. In particular, we show how to synthesize the observed event‐risk across studies while accounting for the within‐study association between participant‐level covariates and individual event probability. The models are adapted for situations where studies provide individual participant data (IPD), or a mixture of IPD and aggregate data. We show that the availability of IPD is crucial in at least some studies; this allows one to model potentially complex within‐study associations and separate them from across‐study associations, so as to account for potential ecological bias and study‐level confounding. The models can produce pertinent population‐level and individual‐level results, such as the pooled event‐risk and the covariate‐specific event probability for an individual. Application is made to 14 studies of traumatic brain injury, where IPD are available for four studies and the six‐month mortality risk is synthesized in relation to individual age. The results show that as individual age increases the probability of six‐month mortality also increases; further, the models reveal clear evidence of ecological bias, with the mean age in each study additionally influencing an individual's mortality probability. Copyright © 2010 John Wiley & Sons, Ltd.
Robust variance estimation in meta‐regression with dependent effect size estimates
Authors: Hedges Larry V. , Tipton Elizabeth , Johnson Matthew C. 
Published: March 2010

AbstractConventional meta‐analytic techniques rely on the assumption that effect size estimates from different studies are independent and have sampling distributions with known conditional variances. The independence assumption is violated when studies produce several estimates based on the same individuals or there are clusters of studies that are not independent (such as those carried out by the same investigator or laboratory). This paper provides an estimator of the covariance matrix of meta‐regression coefficients that are applicable when there are clusters of internally correlated estimates. It makes no assumptions about the specific form of the sampling distributions of the effect sizes, nor does it require knowledge of the covariance structure of the dependent estimates. Moreover, this paper demonstrates that the meta‐regression coefficients are consistent and asymptotically normally distributed and that the robust variance estimator is valid even when the covariates are random. The theory is asymptotic in the number of studies, but simulations suggest that the theory may yield accurate results with as few as 20–40 studies. Copyright © 2010 John Wiley & Sons, Ltd.