bluuebunny/crossref_metadata_2025_split huggingface dataset:
The assessment of glutathione, glutathione peroxidase, glutathione reductase, and oxidized glutathione in patients with periodontitis—A systematic review and meta‐analysis
Authors: Mohideen Khadijah , Krithika Chandrasekaran , Jeyanthikumari T. , Vani N. V. , Dhungel Safal , Ghosh Snehashish 
Published: June 2024

AbstractObjectiveThe present systematic review explored the involvement of enzymatic and nonenzymatic antioxidants in periodontitis, drawing from established literature.Materials and MethodsThe research approach encompassed an extensive electronic search from 2000 to 2023 across databases such as PubMed, Science Direct, and Wiley Online Library and cross‐referencing using specific keywords.ResultsThe initial literature exploration generated a total of 766 articles. After thoroughly examining the abstracts, 693 articles were excluded from consideration due to duplication and lack of relevance to the central research inquiry. Following that, 73 articles were left for in‐depth evaluation. Following a qualitative assessment, 35 studies that satisfied the inclusion criteria were chosen, while 38 were removed for not meeting the necessary standards. Within this selection, a meta‐analysis was conducted on 11 articles that provided consistent data for quantitative synthesis. Specifically, the analysis of glutathione (GSH) levels in serum samples revealed a standardized mean difference (SMD) of −5.552 µg/mL (CI 95%: −9.078 to −2.026; P‐0.002). In contrast, the analysis of glutathione peroxidase (GPx) enzymes in gingival crevicular fluid (GCF) samples displayed an overall SMD of 2.918 ng/µL (CI 95%: 0.372–5.465; P‐0.025), while salivary samples exhibited an overall SMD value of 0.709 U/l (95% CI: −1.907–3.325; P‐0.596) which is of insignificant.ConclusionThe systematic review findings suggest a notable decrease in antioxidant enzymes across various systemic biological samples among patients with periodontitis, contrasting with the results from gingival tissue samples meta‐analysis of GPx enzyme.
Investigating the effect of depression on clinical symptoms of temporomandibular disorder in young stressful men
Authors: Sadrzadeh Afshar Maryam , Salari Behzad , Nejad Sina Varasteh 
Published: June 2024

AbstractObjectivesThe objective of this study was to investigate the relationship of the depression level with temporomandibular disorders (TMDs) in young conscripts as a population with chronic stresses.Material and MethodsA total number of 144 male conscripts with chronic stress and different levels of depression were assigned to four groups according to the Beck's Depression Inventory (BDI). The control group consisted of age‐matched male conscripts without chronic stress. The diagnosis of TMD was made according to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD). Data were analyzed using Mann–Whitney and chi‐square tests.ResultsThe participants with severe depression were significantly more susceptible to have TMD (p = .001) followed by the moderate depression, borderline clinical depression, mild mood disturbance, and control groups. The TMD diagnoses were more prevalent within depression groups compared with the control population (p = .01).ConclusionsThe level of depression is directly associated with the presence of TMD in young men with chronic stress.
Prevalence of Histopathologic Types of Gingival Lesions in the Iranian Population: A 22‐Year Retrospective Study
Authors: Shamloo Nafiseh , Alam Mostafa , Khaleghi Armin 
Published: June 2024

ABSTRACTObjectivesGingiva is one of the supporting tissues around the teeth that can be affected by various neoplastic or nonneoplastic lesions. Previous studies have examined several types of gingival lesions, but the lack of a standardized classification system has hindered meaningful comparisons. Additionally, many studies focused primarily on reactive lesions. Our study aims to contribute to the understanding of gingival lesions by investigating their prevalence across age groups, genders, sites, and by their clinical presentation. This research could lead to improved diagnostic accuracy and treatment strategies.Materials and MethodsThis retrospective study explores the prevalence of gingival lesions based on biopsies during a 22‐year span. The patient's demographic details, including age, gender, and lesion's clinical presentation were systematically collected. These lesions were categorized into six groups. Descriptive statistics, χ2 test of independence, and one‐way ANOVA were used for data analysis.ResultsAmong the 7668 biopsied lesions, 684 (8.9%) lesions were located in the gingiva, with a greater occurrence in women (63.5%). Soft tissue tumors represented the most prevalent group in the gingival lesions (72.1%), and peripheral giant cell granuloma (PGCG) was the most frequent lesion (21.2%), followed by, pyogenic granuloma (19.3%), peripheral ossifying fibroma (17.8%) and focal fibrous hyperplasia (7.6%); all of which predominantly affected women, with mean ages falling in the fourth decade of life. Squamous cell carcinoma was recognized as the most common malignancy.ConclusionIn this study, PGCG was found to be the most common lesion in the gingiva in Iranian population. Further analysis using a unanimous categorization is required to confirm these results.
Synergy of 6G technology and IoT networks for transformative applications
Authors: Das Moupriya , Nag Anindya , Hassan Md. Mehedi , Santra Arkya , Chand Nisarga , Yasmin Farhana , Sinha Anurag , Bairagi Anupam Kumar , Alkhayyat Ahmed 
Published: June 2024

SummaryThe rapid growth of Wi‐Fi networking and intelligent systems, fueled by the emergence of the Internet of Things (IoT), has enabled significant transformative advancements. The imminent arrival of sixth‐generation (6G) wireless networks offers more opportunities as fifth‐generation (5G) wireless networks improve IoT connections. This study explores the potential advantages of 6G technology and IoT networks, focusing on edge intelligence, reconfigurable smart surfaces, Terahertz communications, and blockchain integration. The study examines potential implementation challenges and highlights the potential impact of 6G on IoT device usage. This research outlines potential applications of 6G in many sectors like the internet of vehicles, healthcare, autonomous driving, unmanned aerial vehicles, satellite television, and industrial IoT. This research elaborates on specific research topics related to 6G‐IoT technologies to enhance understanding and practical applicability.
Experimental and numerical studies on the seismic performance of fully cast‐in‐situ concrete exterior walls
Authors: Jiang Qing , Su Wenji , Chong Xun , Liang Jiahui , Yin Bo , Song Pengcheng , Feng Yulong 
Published: June 2024

AbstractTo investigate differences in the seismic performance of the main structure between a window sill wall and a coupling beam under two different flexible connections, two coupled shear wall specimens with concrete window sill walls and one counterpart specimen without infill walls (S‐1) were designed for quasistatic tests. The test results indicated the following: In specimen S‐2, fully disconnected by polyvinyl chloride (PVC) tubes, the coupling beam and window sill wall formed a double coupling beam working mode. The failure mode of the main structure of specimens S‐1 and S‐2 was the beam‐hinge mechanism. In specimen S‐3, which was partially disconnected by extruded polystyrene board strips, the coupling beam and the window sill wall worked together as an integral beam and underwent shear failure, revealing significant differences in failure mode compared to S‐1. In addition, the relative deformation between the first‐floor window wall and the main structure of specimen S‐2 could occur, and the interaction between the two was relatively small compared with that of specimen S‐3. Similarly, compared with those of specimen S‐1, the peak loads of specimens S‐2 and S‐3 were approximately 52.37% and 79.99% greater, respectively. The ductility coefficient of S‐2 was equivalent to that of S‐1, while the displacement ductility coefficient of S‐3 decreased by approximately 41.95% compared to that of S‐1. The connection between the main structure and the concrete infill wall with PVC effectively reduced the interaction between the two components and reduced the damage. Finally, MSC. Marc software was used to establish a solid model and simplified model of the equivalent compression bars of all the specimens, and the results were compared with the test results.
Seismic fragility analysis of human perception in high‐rise buildings subjected to far‐field long‐period earthquake ground motions: A case study for Shanghai tower
Authors: Ning Chao‐Lie , Samit Shrestha , Ji Kun 
Published: June 2024

AbstractHuman perception in high‐rise buildings during far‐field long‐period earthquake ground motions often induces psychological discomfort, including fear and anxiety. A comprehensive understanding on human perception of seismic events is vital for city planning and emergency management, facilitating effective evacuation plans and minimizing stampede risks. This study addresses a gap by employing the seismic fragility analysis method to delineate how human perception in high‐rise buildings is affected during far‐field long‐period ground motions. The methodology involves several key steps. First, the far‐field long‐period earthquake ground motion was identified by detecting the later‐arriving surface waves, and a series of records were selected from the next generation attenuation (NGA) West‐2 ground motion database of the Pacific Earthquake Engineering Research center. Then, a high‐rise building in Shanghai, China was modeled using ETABS 20. Through the linear‐elastic time history analysis, the structural seismic response at each floor was computed. Furthermore, human perception thresholds to vibration were introduced to assess the degree of human perception at each floor, illustrating the difference of human perception to seismic tremor at different floors. Finally, a novel earthquake intensity measure (IM), namely average response spectrum intensity (ARSI) within the vibration period ranging from 0.1 s to 10 s was introduced to generate seismic fragility curves for human perception. According to the investigation, it was found that the corner frequency and the associated energy ratio are useful indicators to identify the far‐field long‐period earthquake ground motions. The ARSI is an effective parameter to assess human perception to seismic tremor compared to the spectral acceleration at a given fundamental period. The generated seismic fragility analysis can provide a complete and thorough understanding on the probability of people that should be evacuated under different earthquake intensity levels. The probability of human perception at different floors varies along the building height, demonstrating the difficulty to make crowd evacuation plan in practice. This insight is vital for understanding and mitigating seismic concerns in high‐rise buildings, particularly in low‐to‐moderate seismicity regions.
Organocatalytic Diastereo‐ and Enantioselective Michael Addition of α‐Aryl Isocyanoacetates to Aurone‐Derived Azadienes
Authors: Laviós Adrián , Sanz‐Marco Amparo , Vila Carlos , Blay Gonzalo 
Published: June 2024

AbstractA highly diastereo‐ and enantioselective organocatalytic Michael addition of α‐aryl isocyanoacetates to aurone‐derived azadienes under mild conditions has been developed. This efficient methodology enables access to chiral α,α‐disubstituted α‐amino ester derivatives with two adjacent stereocenters, one of them quaternary, bearing a benzofuran scaffold in their structure in high yields and stereocontrol. Furthermore, the reaction product can be readily converted into an α,α‐disubstituted α‐amino acid in high yield via hydrolysis of the isocyano group without compromising enantioselectivity.
Organocatalytic Activation of Unsymmetrical 2,3‐Diketones Towards Catalytic Asymmetric Domino Michael–Henry Reaction
Authors: Adam Włoszczak Łukasz , Górecki Marcin , Mlynarski Jacek 
Published: June 2024

AbstractIn this study, we explored a method to distinguish between both enolizable regions of unsymmetrical 2,3‐diketones in organocatalytic domino reactions involving nitroalkenes. The selective formation of an enamine from only one side of the molecule was made possible by the use of optically pure 2‐(trifluoromethyl)pyrrolidine. This catalyst, remarkably enhancing the reaction, owes its efficacy to a unique interplay between basicity and nucleophilicity. These features caused the enolization of the substrate at the second possible site to be omitted. The approach resulted in excellent regio‐ diastereo‐ and enantioselectivity (91–99 % ee) across various nitroalkenes, leading to the synthesis of novel cyclopentanone derivatives with three contiguous stereogenic center.
Water exchange across the blood–brain barrier and epilepsy: Review on pathophysiology and neuroimaging
Authors: Abdennadher Myriam , Jacobellis Sara , Václavů Lena , Juttukonda Meher , Inati Sara , Goldstein Lee , van Osch Matthias J. P. , Rosen Bruce , Hua Ning , Theodore William 
Published: June 2024

AbstractThe blood–brain barrier (BBB) is a barrier protecting the brain and a milieu of continuous exchanges between blood and brain. There is emerging evidence that the BBB plays a major role in epileptogenesis and drug‐resistant epilepsy, through several mechanisms, such as water homeostasis dysregulation, overexpression of drug transporters, and inflammation. Studies have shown abnormal water homeostasis in epileptic tissue and altered aquaporin‐4 water channel expression in animal epilepsy models. This review focuses on abnormal water exchange in epilepsy and describes recent non‐invasive MRI methods of quantifying water exchange.Plain Language SummaryAbnormal exchange between blood and brain contribute to seizures and epilepsy. The authors describe why correct water balance is necessary for healthy brain functioning and how it is impacted in epilepsy. This review also presents recent MRI methods to measure water exchange in human brain. These measures would improve our understanding of factors leading to seizures.
Thermoeconomic analysis of the IWERS system for steam heat recovery from bakery ovens
Authors: Ríos‐Fernández Juan Carlos 
Published: June 2024

AbstractThe integrated waste energy recovery system (IWERS) recovers heat from bakery ovens in supermarkets and other commercial facilities to heat domestic hot water, resulting in energy savings. This article presents a thermoeconomic analysis of the system's operation in a supermarket over the course of 1 year. The study shows that exergy destruction in IWERS is directly proportional to ambient temperature. During the hottest months of the year, IWERS experiences a 4% decrease in exergy performance, while the exergy unit cost of the product increases by up to 4.2%. Additionally, the steam condenser is responsible for the highest relative exergy destruction, reaching almost 45%. Moreover, the addition of equipment upstream of the process increases the exergy cost of production due to the destruction of exergy in the equipment. These results provide valuable information with important implications for energy efficiency, economic savings, and sustainability. Improving system efficiency would generate substantial benefits in energy savings, economic savings, and environmental impact for all commercial and industrial establishments that use bakery ovens.
Survey respondents' inflation forecasts and the COVID period
Authors: Clements Michael P. 
Published: June 2024

AbstractHow do professionals forecast in uncertain times, when the relationships between variables that held in the past may no longer be useful for forecasting the future? For inflation forecasting, we answer this question by measuring survey respondents' adherence to their pre‐COVID‐19 Phillips curve models during the pandemic. We also ask whether professionals ought to have put their trust in their Phillips curve models over the COVID‐19 period. We address these questions allowing for heterogeneity in respondents' forecasts and in their perceptions of the Phillips curve relationship.
In vitro digestion and culture in Caco‐2 cells to assess the bioavailability of fatty acids: A case study in meat matrix enriched with ω‐3 microcapsules
Authors: Solomando Juan Carlos , Antequera Teresa , Estaras Matías , González Antonio , Perez‐Palacios Trinidad 
Published: June 2024

AbstractThis work aimed to evaluate the Caco‐2 cells as a model to study the epithelial transport of intestinal lipid extracts subjected to in vitro digestion, to establish a standard protocol for the determination of bioaccessibility and bioavailability of fatty acids in meat matrix, especially in those enriched with ω‐3 (eicosapentaenoic (EPA) and docosahexaenoic acids (DHA)). Samples were first subjected to in vitro digestion, and then, the intestinal extract was incubated with Caco‐2 cells. A first trial was conducted to select the most influencing variables on the fatty acid transport during Caco‐2 cell incubation: fat quantity on the intestinal extract, incubation time, and shaking. Then, a second experiment was carried out to determine the influence of these variables, being the fat quantity and the incubation time the most influencing factors on the transport and bioavailability of fatty acids. The effect of shaking was not so marked but seemed to improve the bioavailability of saturated fatty acids. This study also allows establishing the most suitable conditions: intestinal extracts with 30 mg of fat, longer incubation times (8 h), and shaking, achieving active and passive fatty acid transport without compromising the integrity of the Caco‐2 cell monolayer. The accurate results obtained for major and minor fatty acids, especially EPA and DHA are remarkable, due to the interest in these bioactive compounds. Thus, this study provides a combined protocol based on static in vitro digestion followed by Caco‐2 cell incubation to assess the bioaccessibility and bioavailability of fatty acids in meat samples.
Detection of pathogenic bacteria in retailed shrimp from Bangladesh
Authors: Khan Murshida , Rahman Md. Mahbubur , Paul Sulav Indra , Lively Julie Anderson 
Published: June 2024

AbstractThe presence of pathogenic bacteria is a problem that might be present in farmed shrimp due to exposure in the environment or post‐harvest handling. Retail farmed shrimp in Bangladesh (Penaeus monodon and Macrobrachium rosenbergii) were tested for common pathogenic bacteria namely Salmonella, L. monocytogenes, Vibrio spp., and E. coli. None of these bacteria were found and instead Enterobacter cloacae, Escherichia fergusonii, Proteus penneri, Klebsiella aerogenes, Enterococcus faecalis, Serratia marcescens, Citrobacter freundii, and Aeromonas dhakensis were detected. Pathogenic bacteria found in Bangladeshi shrimp may be due to the farm environment, poor handling during harvest or post‐harvest, or unhygienic market conditions. The results indicate that retail shrimp from Bangladesh have food safety concerns. Proper laws and policies need to be enforced and implemented to ensure food safety related to fish and shrimp.
Rethinking counterfeit medical supply chains: A critical review of the current literature
Authors: Syed Iffath U. , Milburn Travis W. 
Published: June 2024

AbstractThe medical device and pharmaceutical industries include a range of drugs, machines, instruments, and apparatuses used to prevent, diagnose, treat disease and illness, or aid in rehabilitation for patients, and are expected to grow substantially in the coming years. However, they are often targets of criminal organizations who manufacture and profit from fraudulent products, infiltrating the market with counterfeit medical supply chains. In this paper, we discuss and analyze the extent and nature of this problem and make suggestions for mitigation and prevention of this worldwide challenge. Ultimately, we argue that a holistic approach is essential to addressing this problem, including the creation and dissemination of reliable and good quality data, developing healthcare systems to be more robust, establishing/enhancing intra‐ and international cooperation around this issue, and employing effective technological solutions, such as digital tracing.
Comparative analysis of viscous dissipation effects on Prandtl fluid including contraction and relaxation phenomena
Authors: Shaheen Aqila , Siddique Imran , Huma Zile , Ahsan Muhammad , Khalid Zainab 
Published: June 2024

AbstractThis paper investigates the effects of magnetohydrodynamics and heat transfer on the peristaltic transport of Prandtl fluid in a vertical endoscopic tube. The reduction of the complexity of the equations governing the flow of Prandtl fluid entails the use of long wavelength and low Reynolds number approximations. These complex equations for the pressure gradient and velocity profile are handled analytically using the perturbation technique with convective boundary conditions, and the temperature and concentration profiles are carefully solved for the exact solution. The frictional forces and pressure rise are also simulated with numerical integration. The resulting formulas for velocity, temperature, concentration, pressure rise, and pressure gradient are graphed using the MATLAB and MATHMATICA software, and the effects of all the different physical parameters are investigated and assessed. The streamlines with five distinct wave types are sketched at the conclusion to show the phenomenon of trapping. It is investigated that the velocity profile rises due to buoyancy forces and falls due to the influence of magnetic forces.
Numerical and experimental investigation of the effect of intact egg orientation and yolk positions on heat transfer and cold point location
Authors: Wantha Channarong 
Published: June 2024

AbstractThis paper explores the effects of egg orientation and yolk position during thermal processing using computational fluid dynamics simulation and experimentation. A carboxymethyl cellulose suspension was used to simulate the egg white, and a two‐dimensional model incorporated an air cell near the larger end. The simulation included four cases: two focused on vertical orientation with the yolk at the rear shell and the geometric center, and two on horizontal orientation with similar yolk positions. Repositioning the yolk in a horizontal orientation near the eggshell resulted in significant temperature variations. The findings show that a horizontal egg position, especially with the yolk near the eggshell, led to a significant 8%–16% reduction in heating times. This configuration also improved pasteurization efficiency, assessed by the F value, by about 13.8%. The study also revealed distinct flow patterns influenced by buoyancy forces, significantly related to temperature distribution inside the egg.
Expanding the Scope of Ribosome‐Mediated Biosynthesis in vitro using tRNA‐Aminoacylating Ribozyme
Authors: Cho Namjin , Jin Haneul , Jeon Hyewon , Lee Kanghun , Lee Joongoo 
Published: June 2024

AbstractProteins are synthesized within ribosomes through the polymerization of amino acids (AAs). This process requires prior activation of AAs through aminoacylation that attaches them to their corresponding transfer RNAs (tRNAs). Within cells, this attachment is facilitated by aminoacyl‐tRNA synthetase, resulting in a tRNA:AA conjugate. A set of ribozymes developed to acylate tRNA with non‐canonical substrates enables this process outside the confines of living cells, thereby facilitating the synthesis of novel bio‐based products. In modern biotechnology, aminoacylating ribozymes contribute to the production of innovative bio‐based materials bearing functional non‐canonical chemical substrates (NCSs) and fill the gaps in synthesizing unique polymeric backbones, extending the scope beyond traditional peptide bonds. This review summarizes current understanding of flexizymes at the molecular level and their application in generating exceptional polymeric backbones through ribosome‐mediated synthesis in vitro.