bluuebunny/crossref_metadata_2025_split huggingface dataset:
Practice is the best of all instructors—Effects of enactment encoding and episodic future thinking on prospective memory performance in high‐functioning adults with autism spectrum disorder
Authors: Faustmann Larissa L. , Altgassen Mareike 
Published: May 2024

AbstractProspective memory (PM) is the ability to remember to carry out intended actions in the future. The present study investigated the effects of episodic future thinking (EFT) and enactment encoding (EE) on PM performance in autistic adults (ASD). A total of 72 autistic individuals and 70 controls matched for age, gender, and cognitive abilities completed a computerized version of the Dresden breakfast Task, which required participants to prepare breakfast following a set of rules and time restrictions. A two (group: ASD vs. controls) by three (encoding condition: EFT vs. EE vs. standard) between‐subjects design was applied. Participants were either instructed to engage in EFT or EE to prepare to the different tasks prior to performing the Dresden breakfast or received standard instructions. Analyses of variance were conducted. Autism‐spectrum‐disorders (ASD) participants did not differ from control participants in their PM performance, regardless of which strategy they used. Compared to the standard condition, EE but not EFT improved time‐based PM performance in all participants. This is the first study to find spared time‐based PM performance in autistic individuals. The results confirm earlier results of beneficial effects of EE on PM performance. Findings are discussed with regards to the methodology used, sample composition as well as autistic characteristics.
Potential risk factors for hypospadias and negative correlation with DICER1 (rs3742330) A>G variant in Algerian population: A case‐control study
Authors: Rania Laouar , Djalila Chellat , Brahim Djoudi , Rayene Achou , Meroua Horchi , Souhem Touabti , Zoubir Atrih , Hichem Choutri , Asma Boukri , Dalila Satta , Karima Sifi 
Published: May 2024

AbstractBackgroundHypospadias continues to be a prevalent congenital anomaly affecting the male external genitalia, characterized by an unclear origin and complex treatment approaches. This study aimed to investigate the risk factors associated with hypospadias and explore its genetic link with the DICER1 rs3742330 variant.MethodsThe study involved two groups: 105 male children with hypospadias and 111 healthy male children as matched controls. Detailed history and physical examinations were conducted for all patients and controls. PCR‐restriction fragment length polymorphism was utilized to identify the DICER1 rs3742330 variant, analyzing genotype distribution and allele frequency. Logistic regression analysis estimated the risk factors for hypospadias.ResultsThe mean age in the hypospadias group was 4.56 ± 2.50 years. The most prevalent type of hypospadias observed was the anterior type in 60 children (57.14%). Intrauterine growth restriction, advanced maternal age, and gestational hypertension were identified as significant risk factors for hypospadias (p = .011, p = .016, and p = .041, respectively). Regarding the genetic study, no significant difference was found in both genotype and allele frequencies of the DICER1 rs3742330 variant between case and control groups.ConclusionsThe rs3742330 variant in the DICER1 gene showed no association with hypospadias cases in the Algerian population. However, multivariate logistic regression analysis identified preterm birth, low birth weight, intrauterine growth restriction, advanced maternal age, gestational diabetes, and rural residence as the most significant independent predictors for hypospadias.
Luftporenbeton mit superabsorbierenden Polymeren (SAP) Teil 1
Authors: Schack Tobias , Dittmar Sebastian , Schauerte Matthias , Mazanec Oliver , Haist Michael 
Published: May 2024

AbstractSuperabsorbierende Polymere (SAP) besitzen die Fähigkeit, ein Vielfaches ihres eigenen Trockengewichts an wässriger Lösung aufzunehmen und zu speichern. Entsprechend wird in der Literatur vielfach der Einsatz von SAP zur inneren Nachbehandlung von Beton beschrieben. Die SAP speichern Wasser und geben es während der Hydratation langsam ab. Infolge der Wasserabgabe schwinden die Polymere und es verbleiben entsprechende Luftporen im Betongefüge zurück. So stellen SAP gleichzeitig eine Alternative zu klassischen LP‐Bildnern zur Steigerung des Frost‐ und Frost‐Tausalz‐Widerstands von Beton dar. Im Rahmen des vorliegenden Beitrags werden systematische Untersuchungen zur Herstellung von LP‐Betonen mittels superabsorbierender Polymere als Alternative zu klassischen LP‐Bildnern beschrieben und diskutiert. In Teil 1 des Beitrags wird der Einfluss der SAP auf die Frischbetoneigenschaften beschrieben. Der Fokus der experimentellen Untersuchungen lag dabei auf den resultierenden Veränderungen der rheologischen Eigenschaften sowie der Entmischungsneigung (Sedimentation der groben Gesteinskörnung und Neigung zur Wasserabsonderung) des Frischbetons bei Anwendung von superabsorbierenden Polymeren. In weiteren Teilen werden die Festbetoneigenschaften (Teil 2) sowie die Robustheit gegenüber stofflichen und umgebungsbedingten Schwankungen (Teil 3) der Betone mit SAP beschrieben und diskutiert.
Fluorescent‐protein co‐expression to select CHO cells expressing high quantities of vaccine antigens
Authors: Ganguly Jishna , Fu Zongming , Marion James , Pan Yan , Ruano John , Dahle Michael , Li Xiangming 
Published: May 2024

AbstractCell line development for production of vaccine antigens or therapeutic proteins typically involves transfection, selection, and enrichment for high‐expressing cells. Enrichment methods include minipool enrichment, antibody‐based enrichment, and enrichment based on co‐expressed fluorescent biosensor proteins. However, these methods have limitations regarding labor and cost intensity, the generation of antibodies and assurance of their viral safety, and potential expression‐interference or signal‐saturation of the co‐expressed fluorescent protein. To improve the method of fluorescent‐protein co‐expression, expression constructs were created that constitutively express a model vaccine antigen together with one of three fluorescent proteins having translation initiation controlled by a wildtype or mutant internal ribosome entry site (IRES), for a total of six constructs. The constructs were transfected into Chinese hamster ovary cells (CHO) cells, enriched for high fluorescence, cultured, and tested in a mini bioreactor to identify the most promising construct. The fluorescent protein, Fluorescent Ubiquitination‐based Cell Cycle Indicator (FUCCI) with a mutant IRES performed best and was further tested with three additional vaccine antigens. Across the four vaccine antigens, the FUCCI fluorescent protein yielded productivity enhancements, without the need for generating an antibody and assuring its viral safety. Furthermore, FUCCI protein was present in negligible quantities in the cell supernatant, indicating a low risk for contaminating drug substances or vaccine antigen.
Measuring crowdfunding success for small and medium‐sized enterprises sustainable development: Insight from the social networking theory
Authors: Okine Agnes Naa Dedei , Li Yao , Djimesah Isaac Edem , Zhao Hongjiang , Duah Elijah , Kissi Mireku Kingsford , Adjei Budu Kenneth Wilson , Adjei Daniel Baani 
Published: May 2024

AbstractWith little to no study on the effect of social networking theory on the success of a crowdfunding campaign in Africa, this study investigated some of the factors that influence the success of a crowdfunding campaign using Ghana as a case for a broader justification and generalization of findings that has been obtained in previous studies. This study identified four factors through an extensive literature review of the social networking theory. These are the number of social network handless of an entrepreneur, activeness of an entrepreneur on a social network, number of social network friends of an entrepreneur and the availability of project videos on an entrepreneur's social network. Data were then collected empirically from 462 respondents using a questionnaire. The data obtained were analyzed using the partial least square structural equation modeling. The results revealed that all the identified factors positively influence the success of a crowdfunding campaign. The study further proposes that fund seekers on the crowdfunding platform post their project information on weekends and evenings on weekdays since people pay special attention to information posted at these times. Also, the outcome of the importance performance map analysis disclosed that the number of social network handles of an entrepreneur is the most essential in terms of importance when seeking funds on the crowdfunding platform. This study provides valuable insight into how small and medium‐sized enterprises in Ghana and other stakeholders of crowdfunding platforms can use the concept of social networking theory to achieve funding success on crowdfunding platforms.
Lateral medullary syndrome in a resources limited hospital: A rare clinical anatomical variation of ischemic stroke
Authors: Ebraheem Ahmed Alsiddig , Dafallah Mumen Abdalazim , Mohamamed Khawla Abdelmonem Yousef 
Published: May 2024

Key Clinical MessageAlthough it is rare, physicians should be familiar with the presentation of lateral medullary syndrome (LMS). Urgent neuroimaging is crucial to distinguish LMS from other causes of stroke. The majority experience significant improvement within months.AbstractLateral medullary syndrome is a rare type of stroke resulting from a vascular event in the lateral part of the medulla oblongata. Loss of pain and temperature in the ipsilateral side of the face, and contralateral side of the body along with ipsilateral ataxia, vertigo, nystagmus, dysphagia, and hiccups are the hallmark clinical presentation. We reported a case of a 51‐year‐old male with a long history of smoking and newly discovered hypertension who presented complaining of vomiting, regurgitation, and hiccups for 1 month; tingling and numbness sensation in the left side of the face and the right side of the body, and unsteady gait for 2 weeks. Neurological examinations revealed left‐sided ptosis and miosis, diminished sensation of the three divisions of the trigeminal nerve, deviated uvula to the right side, absent gag reflex, and intention tremors. The patient received the appropriate treatment; showed a good recovery with his symptoms, was able to walk unsteady, and was discharged after 10 days in a good condition.
Exploiting Hydrophobic Amino Acid Scanning to Develop Cyclic Peptide Inhibitors of the SARS‐CoV‐2 Main Protease with Antiviral Activity
Authors: Harrison Katriona , Carlos Patrick W. , Ullrich Sven , Aggarwal Anupriya , Johansen‐Leete Jason , Sasi Vishnu Mini , Barter Isabel , Maxwell Joshua W. C. , Bedding Max J. , Larance Mark , Turville Stuart , Norman Alexander , Jackson Colin J. , Nitsche Christoph , Payne Richard J. 
Published: May 2024

AbstractThe development of novel antivirals is crucial not only for managing current COVID‐19 infections but for addressing potential future zoonotic outbreaks. SARS‐CoV‐2 main protease (Mpro) is vital for viral replication and viability and therefore serves as an attractive target for antiviral intervention. Herein, we report the optimization of a cyclic peptide inhibitor that emerged from an mRNA display selection against the SARS‐CoV‐2 Mpro to enhance its cell permeability and in vitro antiviral activity. By identifying mutation‐tolerant amino acid residues within the peptide sequence, we describe the development of a second‐generation Mpro inhibitor bearing five cyclohexylalanine residues. This cyclic peptide analogue exhibited significantly improved cell permeability and antiviral activity compared to the parent peptide. This approach highlights the importance of optimizing cyclic peptide hits for activity against intracellular targets such as the SARS‐CoV‐2 Mpro.
Boron‐Stereogenic Compounds: Synthetic Developments and Opportunities
Authors: Guo Yonghong , Zu Bing , Du Chen Cadmus , He Chuan 
Published: May 2024

Comprehensive SummaryThe 21st century has witnessed a continuous evolution in the development of boron‐stereogenic chemistry. Since the 1990s, various innovations for the synthesis of tetracoordinate boron‐stereogenic compounds, which exhibited great potential applications, have been demonstrated by synthetic chemists. This paper reviews the significant progress and recent advances towards the assembly of enantioenriched boron‐stereogenic compounds, and hopes to shed light on new perspectives and inspire further research in this emerging field.
Rational Designing MxSy@C (M=Ni, Co, Zn, Cu, Mn) Composites with Controlled Polysuifides Shuttling Behaviors towards Advanced Stable Room Temperature Na‐S Batteries†
Authors: Huang Wei , Chen Yumeng , Chen Jing , Shi Wei , Xua Guangliang , Yang Yingchang 
Published: May 2024

Comprehensive SummaryRoom‐temperature sodium‐sulfur (RT‐Na/S) batteries display attractive potential in large‐scale energy‐storage, but their practical application was still restricted by the serious dissolution of polysulfides. Herein, supported by the constructing of interface engineering, the metal sulfide‐carbon nanocomposite can be prepared with considerable electrochemical properties. Utilizing the double‐helix structure of carrageenan‐metal hydrogels as precursors, in‐situ metal sulfide (MxSy) nanostructure/3D carbon aerogels (3D CAs) can be successfully constructed. Importantly, with the assistance of the vulcanization process, 3D carbon architecture was maintained in the composites and acted as a skeleton to optimize their structural stability. As the cathode of RT‐Na/S batteries, ZnS/S@C and NiS2/S@C delivered an excellent cycling stability and rate performance (179.8 mAh·g−1 at 20 A·g−1 after 10000 cycling for ZnS/S@C, 220.3 mAh·g−1 at 10 A·g−1 after 3000 cycling for NiS2/S@C). The detailed investigation of mechanism revealed that the powerful adsorption for Na2S4 originated from 3D metal sulfide‐carbon structure. The well‐designed architecture of sulfide‐carbon composites servers as an electrocatalyst to alleviate the shuttle effect of polysulfides, resulting in the long‐term electrochemical stability. Given this, the work is expected to provide promising insights for designing advanced cathode materials for RT‐Na/S batteries.
Gradual or Hysteretic Transition: Anion Effects on Cobalt(II) Spin Crossover Complexes
Authors: Sun Yu‐Chen , Li Ying‐Lian , Zhang Cheng‐Cheng , Chen Feng‐Li , Shao Dong , Zhao Yue , Wei Hai‐Yan , Wang Xin‐Yi 
Published: May 2024

Comprehensive SummaryTo better understand the impact of different anions on the structures and SCO properties of the CoII SCO complexes, six new complexes [Co(terpy‐CH2OH)2]A2·sol (terpy‐CH2OH = 4′‐(hydroxymethyl)‐2,2′;6′,2″‐terpyridine, A = Br– (1, sol = 1.5H2O), I– (2), N3– (3, sol = 2H2O), H3BCN– (4), OTf– (5), and TsO– (6, sol = 4H2O·CH3CN), have been synthesized and characterized. All six compounds consist of mononuclear [Co(terpy‐CH2OH)2]2+ cations and charge‐balancing anions that differ in size, shape, and hydrogen bonding capacity. Complexes 1, 2, 3, and 6 displayed incomplete gradual SCO transitions, whereas 4 and 5 exhibited abrupt hysteretic spin transitions with loops of 12 and 16 K (250.0—262.0 K for 4, and 370.0—386.0 K for 5, respectively), closely resembling our previously reported complexes with SCN– and SeCN– anions. The occurrence of the order‐disorder transition of the CH2OH groups and their transition temperatures are determined by the size and hydrogen bonding capability of the anions. Remarkably, the transition temperatures of complexes with H3BCN–, SCN–, OTf–, and SeCN– anions exhibit an upward trend as the size and mass of the anions increase, as confirmed through detailed single crystal structure analyses conducted in both high‐spin and low‐spin states for all four complexes.
Roles of Metal‐Organic Framework Supports in Base‐Free Oxidation of 5‐Hydroxymethylfurfural to Furan‐2,5‐Dicarboxylic Acid over Pt‐Based Catalysts
Authors: Seehamongkol Theerada , Rungtaweevoranit Bunyarat , Chakthranont Pongkarn , Butburee Teera , Nimsaila Weerawan , Faungnawakij Kajornsak 
Published: May 2024

AbstractThe catalytic oxidation of 5‐hydroxymethylfurfural (HMF) is an important process for producing a renewable furan‐2,5‐dicarboxylic acid (FDCA). Although several Pt‐based catalysts have been reported to efficiently catalyze the oxidation of HMF, the functional roles of catalyst supports, as corroborated by spectroscopic techniques, have not been fully described. Here, we report on Pt nanoparticles supported on metal‐organic frameworks (MOFs) that catalyze the oxidation of HMF to FDCA in the absence of base. Several catalysts are prepared by immobilizing pre‐synthesized Pt nanoparticles on supports, allowing for the investigation of the role of the supports without the influence of the size of Pt nanoparticles (Pt NPs). By analyzing the catalytic performances along with the electronic properties using X‐ray photoelectron spectroscopy and surface properties of the catalysts using in situ infrared spectroscopy of adsorbed CO2, we find that the presence of Pt NPs in the metallic phase and basic hydroxyl groups on the support promote the HMF oxidation.
Control of Iron(II)‐Tris(2,2’‐Bipyridine) Light‐Induced Excited‐State Trapping via External Electromagnetic Fields
Authors: Alías‐Rodríguez M. , Huix‐Rotllant M. 
Published: May 2024

AbstractLight‐induced excited spin‐state trapping reactions in iron pyridinic complexes allow the iron's low‐to‐high spin transition in a sub‐picosecond timescale. Employing a recently developed model for [Fe(2,2′‐bipyridine)3]2+ photochemical spin‐crossover reaction in conjunction with quantum wavepacket dynamics, we explore the possibility of controlling the reaction through external electromagnetic fields, aiming at stabilizing the initial metal‐to‐ligand charge transfer states. We show that simple Gaussian‐shaped electromagnetic fields have a minor effect on the population kinetics. However, introducing vibrationally excited initial wavepacket representations allows for maintaining the population trapped in the metal‐to‐ligand charge transfer states. Using optimal control theory, we propose an electromagnetic field shape that increases the lifetime of metal‐to‐ligand charge transfer states. These results open the route for controlling the iron photochemistry through the action of external electric fields.
Powerful Role of Benzotriazole Polymers and Small Molecules in Organic Solar Cells
Authors: Torres‐Moya I. 
Published: May 2024

AbstractIn the dynamic landscape of renewable energy technologies, organic solar cells (OSCs) have emerged as frontrunners, offering a sustainable and promising alternative for harnessing solar energy. This review article delves into the recent strides made in leveraging the potential of the benzotriazole nucleus within the context of organic solar cells. The unique electronic properties of benzotriazole, coupled with its structural adaptability, position it as a key component in the pursuit of enhancing OSC performance. As researchers delve deeper into the intricacies of this compound, a clearer understanding of its impact on light absorption, charge transport, and overall device stability emerges. The exploration of recent literature in the last three years reveals a rich landscape with innovation and discovery, showcasing the diverse approaches taken to incorporate benzotriazole into different OSC architectures. From fundamental studies elucidating its electronic interactions to applied research refining its integration strategies, the potential of benzotriazole in advancing the capabilities of organic solar cells becomes increasingly evident, and showing that, with the most important advances in the last three years, is the main goal of this article.
Comparing the efficacy of a novel mucoadhesive patch containing Nigella sativa 10% with triamcinolone 0.1% in patients with erosive‐atrophic oral lichen planus: A pilot study
Authors: Pakfetrat Atessa , Delavarian Zahra , Malakooti Mahshid , Bagheri Hossein , Esmaily Habibollah , Ghorbani Mahsa , Saeedi Pooya 
Published: May 2024

AbstractObjectiveThis study evaluates the efficacy of a novel mucoadhesive patch containing Nigella sativa 10% extract compared to triamcinolone 0.1% in alleviating symptoms and reducing lesion severity in patients with erosive‐atrophic oral lichen planus.Methods and MaterialsA pilot study comprising two groups, each with 10 patients, was conducted. The intervention group received mucoadhesive patches containing N. sativa 10% extract, while the control group received triamcinolone acetonide 0.1% patches. Pain and burning intensity, measured through visual analog scale, and lesion severity based on the Thongprasom scale were assessed weekly for 4 weeks. Descriptive records were kept for side effects and patient satisfaction.ResultsPain and burning intensity decreased in both groups throughout the sessions, with the N. sativa group showing a greater reduction than the triamcinolone group. The reduction in burning intensity within each group was significant (p < .001), and there was a significant difference between groups only in the second session (p = .045). The overall difference between groups was not significant (p > .05). Lesion severity also decreased significantly in both groups (p < .001), with a significant difference between groups observed in the third session (p = .043) and overall throughout the study (p = .006).ConclusionThe use of N. sativa extract in mucoadhesive patches was as effective as corticosteroids in reducing pain, burning, and lesion severity in patients with oral lichen planus, with N. sativa showing superior results in some sessions. Notably, no significant complications were observed with N. sativa use, making it a promising treatment option for lichen planus.