bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal subwork zone operational strategy for short‐term work zone projects in four‐lane two‐way freeways
Authors: Meng Qiang , Weng Jinxian 
Published: November 2010

SUMMARYRoadside trees in Singapore are regularly trimmed for the purpose of traffic safety and roadside tree‐trimming project is one typical type of short‐term work zone projects. To implement such a short‐term work zone project, contractors usually divide an entire work zone into multiple subwork zones with the uniform length. This paper aims to determine an optimal subwork zone strategy for the short‐term work zone projects in four‐lane two‐way freeways with time window and uniform subwork zone length constraints. The deterministic queuing model is employed to estimate total user delay caused by the work zone project by taking into account variable traffic speeds. Based on the user delay estimations, this paper proceeds to build a minimization model subject to time window and uniform length constraints for the optimal subwork zone strategy problem. This paper also presents a variation of the minimization model to examine the impact of unequal subwork zone length constraint. Since these minimization models belong to the mixed‐integer non‐differentiable optimization problems, an iterative algorithm embedding with the genetic simulated annealing method is thus proposed to solve these models. Finally, a numerical example is carried out to investigate the effectiveness of the proposed models. Copyright © 2010 John Wiley & Sons, Ltd.
Solvent‐Dependent cis/trans Isomerism at the Paddlewheel Mo2 Core of Linear Tetranuclear Clusters of MoII and CuI Supported by 6‐(Diphenylphosphanyl)pyridin‐2‐olate (pyphos)
Authors: Pal Kuntal , Nakao Keisuke , Mashima Kazushi 
Published: November 2010

AbstractThe treatment of [Mo2(pyphos)4] (1) (pyphos = 6‐diphenylphosphanyl‐2‐pyridonate) with [Cu(NCCH3)4](PF6) in CH2Cl2 and CH3CN mixed solvent (1:5 v/v) led to the formation of a linear tetranuclear cluster, cis‐[Mo2{Cu(NCCH3)2}2][(pyphos)4](PF6)2 (cis‐2a‐PF6), as a thermodynamic product that was structurally characterized as a tetrakis[3,5‐bis(trifluoromethyl)phenylborate] salt (cis‐2a‐BArF). In the solid‐state structure of cis‐2a‐BArF, the Mo2 core was bridged by two O–N chelating pyphos ligands in a cis fashion, in sharp contrast to a trans fashion in 1. The trans isomer (trans‐2b‐PF6) was isolated from a noncoordinating solvent such as CH2Cl2 and structurally characterized. The transformation from trans‐2b to cis‐2a proceeded in acetonitrile by means of an intramolecular rearrangement of the paddlewheel Mo2 core upon dissolution in acetonitrile, in which the coordinating solvent stabilizes the transient, coordinatively unsaturated Mo2 core upon the release of the pyridonate moiety from the Mo2 core; whereas the reverse reaction did not occur under any trial conditions. A further substitution reaction at the Cu center of cis‐2a‐PF6 and trans‐2b‐PF6 with Et4NCl afforded cis‐3a and trans‐3b, respectively, which have the molecular formula [Mo2(pyphos)4Cu2(Cl)2]. Compounds trans‐3a and cis‐3b do not show any solvent‐dependent interconversion phenomena by changing the solvent.
Synthesis of Aziridine‐ and Oxirane‐2‐phosphonates Spiro‐Fused with Oxindoles
Authors: Gasperi Tecla , Loreto M. Antonietta , Migliorini Antonella , Ventura Claudia 
Published: November 2010

Abstract3‐(Phosphorylmethylene)oxindoles have been prepared by a straightforward Horner–Wadsworth–Emmons reaction. They were treated with ethyl N‐{[(4‐nitrophenyl)sulfonyl]oxy}carbamate (NsONHCO2Et) in the presence of CaO to afford new aziridine‐2‐phosphonates spiro‐fused with oxindole. 3‐(Phosphorylmethylene)oxindoles were also transformed into novel spiro[oxindole‐oxiranes] by reaction with H2O2/NaOH.
Experimental behavior of transfer story connections for high‐rise SRC structures under seismic loading
Authors: Wang Wei , Chen Yiyi , Dong Baiping , Leon Roberto T. 
Published: November 2010

AbstractResults from an investigation aimed at assessing seismic behavior of transfer story connections for high‐rise building consisting of steel‐reinforced concrete (SRC) frame and reinforced concrete (RC) core tube are presented. Two types of transfer story connections were experimentally evaluated for adequate strength, ductility and energy dissipation. For each type of connection, two large‐scale subassembly tests were carried out under monotonic and cyclic lateral displacement, respectively. Detailed observations and behavior responses were obtained to contrast the differences between monotonic and cyclic performance of the connections. Test results showed that the SRC column failed before connection collapse and that loading types have little effect on the strength but greatly affect the failure modes and the ductility of the connections. All specimens exhibited good properties for earthquake resistance since they all kept a stable inelastic behavior up to the interstory drift demand suggested by the AISC Seismic Provisions. Based on test observations, support stiffeners with appropriate width‐to‐thickness ratio and mechanical connectors connecting bars with the steel plate are recommended for design purposes in order to achieve more ductile and reliable seismic behavior of transfer story connections. Copyright © 2010 John Wiley & Sons, Ltd.
Genomic signature of BRCA1 deficiency in sporadic basal‐like breast tumors
Authors: Joosse Simon A. , Brandwijk Kim I. M. , Mulder Lennart , Wesseling Jelle , Hannemann Juliane , Nederlof Petra M. 
Published: November 2010

AbstractAbout 10–20% of all breast carcinomas show a basal‐like phenotype, while ∼ 90% of breast tumors from BRCA1‐mutation carriers are of this subtype. There is growing evidence that BRCA1‐mutated tumors are not just a specific subset of the basal‐like tumors, but that (the majority of) basal‐like tumors show a dysfunctional BRCA1 pathway. This has major treatment implications, because emerging regimens specifically targeting DNA repair mechanisms would then be most effective against these tumors. To further understand the involvement of BRCA1 deficiency in sporadic basal‐like tumors, we investigated 41 basal‐like tumors for BRCA1 mRNA expression by quantitative real‐time polymerase chain reaction, BRCA1 promoter methylation, their genomic profile by array‐CGH, and gene expression levels by whole genome expression arrays. Array‐CGH results were compared to those of 34 proven BRCA1‐mutated tumors. Basal‐like tumors were subdivided into two equal groups: deficient and proficient in BRCA1 gene expression. The chromosomal makeup of BRCA1 deficient sporadic basal‐like tumors was similar to that of BRCA1‐mutated tumors. BRCA1 proficient sporadic basal‐like tumors were more similar to nonbasal‐like tumors. Only half of the basal‐like breast tumors are actually deficient in BRCA1 expression. Gain of chromosome arm 3q is a marker for BRCA1 deficiency in hereditary and sporadic breast tumors. © 2010 Wiley‐Liss, Inc.
Sulfatase 1 and sulfatase 2 in hepatocellular carcinoma: Associated signaling pathways, tumor phenotypes, and survival
Authors: Yang Ju Dong , Sun Zhifu , Hu Chunling , Lai Jinping , Dove Rebecca , Nakamura Ikuo , Lee Ju‐Seog , Thorgeirsson Snorri S. , Kang Koo Jeong , Chu In‐Sun , Roberts Lewis R. 
Published: November 2010

AbstractThe heparin‐degrading endosulfatases sulfatase 1 (SULF1) and sulfatase 2 (SULF2) have opposing effects in hepatocarcinogenesis despite structural similarity. Using mRNA expression arrays, we analyzed the correlations of SULF expression with signaling networks in human hepatocellular carcinomas (HCCs) and the associations of SULF expression with tumor phenotype and patient survival. Data from two mRNA microarray analyses of 139 and 36 HCCs and adjacent tissues were used as training and validation sets. Partek and Metacore software were used to identify SULF correlated genes and their associated signaling pathways. Associations between SULF expression, the hepatoblast subtype of HCC, and survival were examined. Both SULF1 and 2 had strong positive correlations with periostin, IQGAP1, TGFB1, and vimentin and inverse correlations with HNF4A and IQGAP2. Genes correlated with both SULFs were highly associated with the cell adhesion, cytoskeletal remodeling, blood coagulation, TGFB, and Wnt/β‐catenin and epithelial mesenchymal transition signaling pathways. Genes uniquely correlated with SULF2 were more associated with neoplastic processes than genes uniquely correlated with SULF1. High SULF expression was associated with the hepatoblast subtype of HCC. There was a bimodal effect of SULF1 expression on prognosis, with patients in the lowest or highest tertile having a worse prognosis than those in the middle tertile. SULFs have complex effects on HCC signaling and patient survival. There are functionally similar associations with cell adhesion, ECM remodeling, TGFB, and WNT pathways, but also unique associations of SULF1 and SULF2. The roles and targeting of the SULFs in cancer require further investigation. © 2010 Wiley‐Liss, Inc.
A simple and fast two‐locus quality control test to detect false positives due to batch effects in genome‐wide association studies
Authors: Lee Sang Hong , Nyholt Dale R. , Macgregor Stuart , Henders Anjali K. , Zondervan Krina T. , Montgomery Grant W. , Visscher Peter M. 
Published: November 2010

AbstractThe impact of erroneous genotypes having passed standard quality control (QC) can be severe in genome‐wide association studies, genotype imputation, and estimation of heritability and prediction of genetic risk based on single nucleotide polymorphisms (SNP). To detect such genotyping errors, a simple two‐locus QC method, based on the difference in test statistic of association between single SNPs and pairs of SNPs, was developed and applied. The proposed approach could detect many problematic SNPs with statistical significance even when standard single SNP QC analyses fail to detect them in real data. Depending on the data set used, the number of erroneous SNPs that were not filtered out by standard single SNP QC but detected by the proposed approach varied from a few hundred to thousands. Using simulated data, it was shown that the proposed method was powerful and performed better than other tested existing methods. The power of the proposed approach to detect erroneous genotypes was ∼80% for a 3% error rate per SNP. This novel QC approach is easy to implement and computationally efficient, and can lead to a better quality of genotypes for subsequent genotype‐phenotype investigations. Genet. Epidemiol. 34:854–862, 2010. © 2010 Wiley‐Liss, Inc.
The impact of diversity and equality management on firm performance: Beyond high performance work systems
Authors: Armstrong Claire , Flood Patrick C. , Guthrie James P. , Liu Wenchuan , MacCurtain Sarah , Mkamwa Thadeus 
Published: November 2010

AbstractThis article demonstrates that a diversity and equality management system (DEMS) contributes to firm performance beyond the effects of a traditional high‐performance work system (HPWS), which consists of bundles of work practices and policies used extensively in high‐performing firms. A DEMS typically includes diversity training and monitoring recruitment, pay, and promotion across minority or other disadvantaged groups. Our analysis of quantitative data from service and manufacturing organizations in Ireland confirms that HPWS practices are associated with positive business performance and finds specifically that DEMS practices are positively associated with higher labor productivity and workforce innovation and lower voluntary employee turnover. © 2010 Wiley Periodicals, Inc.
Comparison of flood management options for the Yang River Basin, Thailand
Authors: Kuntiyawichai Kittiwet , Schultz Bart , Uhlenbrook Stefan , Suryadi F. X. , Van Griensven A. 
Published: November 2010

ABSTRACTThe Yang River Basin, Thailand, has always been subjected to flooding, but due to recent developments in land use there is an increase in the vulnerability in several parts of the river basin. To mitigate impacts of flooding, both structural and non‐structural measures can be taken. This paper discusses three scenario simulations focusing on flood retardation, retention, and damage mitigation measures. A main tributary was simulated by a process‐based hydrological model (SWAT) and coupled to the 1D/2D SOBEK river routing model. The first scenario focused on retarding basins, the so‐called natural flood storage, to reduce downstream flood flows by storing excess floodwater in low‐lying areas and releasing it after the peak has passed. The second scenario concerned a green river (bypass channel) to provide storage and drainage through a large, shallow retardation basin, and an outlet for water discharge from upstream. The third scenario concerned the effect of dikes to protect areas from inundation. The results show that the green river is the most appropriate solution since it can potentially reduce a 1% to a 10% per year flood event, with a reduction of peak discharges of 14% in comparison to 9.2% reduced by natural flood storage. Copyright © 2010 John Wiley & Sons, Ltd.
Proteasome inhibition causes epithelial–mesenchymal transition upon TM4SF5 expression
Authors: Kim Jin Young , Nam Jae Kook , Lee Sin‐Ae , Lee Mi‐Sook , Cho Somi K. , Park Zee‐Yong , Lee Jung Weon , Cho Moonjae 
Published: November 2010

AbstractTransmembrane 4 L six family member 5 (TM4SF5) is highly expressed in hepatocarcinoma and causes epithelial–mesenchymal transition (EMT) of hepatocytes. We found that TM4SF5‐expressing cells showed lower mRNA levels but maintained normal protein levels in certain gene cases, indicating that TM4SF5 mediates stabilization of proteins. In this study, we explored whether regulation of proteasome activity and TM4SF5 expression led to EMT. We observed that TM4SF5 expression caused inhibition of proteasome activity and proteasome subunit expression, causing morphological changes and loss of cell–cell contacts. shRNA against TM4SF5 recovered proteasome expression, with leading to blockade of proteasome inactivation and EMT. Altogether, TM4SF5 expression appeared to cause loss of cell–cell adhesions via proteasome suppression and thereby proteasome inhibition, leading to repression of cell–cell adhesion molecules, such as E‐cadherin. J. Cell. Biochem. 112: 782–792, 2011. © 2010 Wiley‐Liss, Inc.
The effects of different methods of emotional disclosure: differentiating post‐traumatic growth from stress symptoms
Authors: Slavin‐Spenny Olga M. , Cohen Jay L. , Oberleitner Lindsay M. , Lumley Mark A. 
Published: November 2010

AbstractResearch on emotional disclosure should test the effects of different disclosure methods and whether symptoms are affected differently than post‐traumatic growth. We randomized 214 participants with unresolved stressful experiences to four disclosure conditions (written, private spoken, talking to a passive listener, talking to an active facilitator) or two control conditions. All groups had one 30‐minute session. After 6 weeks, disclosure groups reported more post‐traumatic growth than controls, and disclosure conditions were similar in this effect. All groups decreased in stress symptoms (intrusions, avoidance, psychological and physical symptoms), but disclosure did not differ from control. We conclude that 30 minutes of disclosure leads to post‐traumatic growth but not necessarily symptom reduction, and various disclosure methods have similar effects. Research on the effects of disclosure should focus on the benefits of growth as well as symptom reduction. © 2010 Wiley Periodicals, Inc. J Clin Psychol 00:1‐15, 2010.
Development of a New Polypropylene‐Based Suture: Plasma Grafting, Surface Treatment, Characterization, and Biocompatibility Studies
Authors: Saxena Shalini , Ray Alok R. , Kapil Arti , Pavon‐Djavid Graciela , Letourneur Didier , Gupta Bhuvanesh , Meddahi‐Pellé Anne 
Published: November 2010

AbstractPolypropylene sutures (PP) are already used in surgery. Because microbial infection leads to complications, we developed antimicrobial PP suture by plasma‐induced graft polymerization of acrylic acid followed by chitosan binding on the remaining carboxyl groups. Mechanical properties and surface morphologies were analyzed on these sutures. Tetracycline hydrochloride (TC) or nanosilver (NS) was then immobilized to PP. The resulting PP sutures evidenced drug release properties and antimicrobial activity in vitro. PP implanted in vivo for 30 days in the muscle of rats showed the absence of adverse effects and a tissue organization. This new polypropylene suture with suitable antimicrobial features appears to be a promising macromolecular material for clinical and cosmetic applications.
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Effects of Viscosity‐Controlled Interfacial Mobility on the Coalescence of Immiscible Polymer Blends
Authors: Gabriele Massimiliano , Pasquino Rossana , Grizzuti Nino 
Published: November 2010

AbstractThe consequences of the interfacial mobility on the coalescence process in immiscible polymer blends was studied. Blends of PIB and PDMS with 10 vol.% PIB were subjected to shear‐flow step‐down experiments under controlled conditions. The blend was initially sheared at high shear rate to obtain a fine dispersion (small drop size). The shear rate was then stepped down and the coalescence process was monitored by performing repeated SAOS experiments. In the limit of high and low viscosity ratios, the experimental results were in excellent agreement with theory predictions for IMI and FMI conditions. In the intermediate range of viscosity ratio, corresponding to PMI conditions, a smooth transition between the limiting IMI and FMI states was found.
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Metal‐Catalyzed Synthesis of Alternating Copolymers
Authors: Brulé Emilie , Guo Jia , Coates Geoffrey W. , Thomas Christophe M. 
Published: November 2010

AbstractThe creation of polymers with a high degree of sequence and/or stereocontrol represents an exciting frontier in materials science. In order to obtain alternating polymers, coordination polymerization using well‐defined metal complexes has played a leading role in the last two decades. In the following paper, we will describe selected published efforts to achieve these research goals using discrete, structurally well‐characterized metal complexes.
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Self‐Consistent Theory of Structures and Transitions in Weak Polyampholytes
Authors: Bhattacharjee Abir , Kundu Prasanta , Dua Arti 
Published: November 2010

AbstractWeak polyampholytes are charged polymers, where the charge asymmetry can be tuned by varying the solution pH. We determine the size of a randomly charged weak polyampholyte in dilute solution as a function of charge asymmetry, Bjerrum length, salt concentration, pH, and degree of polymerization, using a self‐consistent method. It is known that in the limiting cases of low and high charge asymmetries, polyampholytes behave as neutral polyampholytes and polyelectrolytes, respectively. We explore in detail the regime of intermediate charge asymmetry where a polyampholyte show non‐monotonic change in the chain size as a function of Bjerrum length. A hierarchy of structures exists at different length scales, ranging from ideal coils at low Bjerrum length, extended rod‐like state at intermediate Bjerrum length to globular states at high Bjerrum length. The transition between ideal coil and rod‐like states is continuous, while that between rod‐like and globular states is discontinuous. The addition of salt changes the nature of the rod‐to‐globule transition from discontinuous to continuous. The effective free energy shows a double minimum at intermediate charge asymmetry, indicating the coexistence of globules and extended states. The size as a function of the solution pH shows a minimum at the isoelectric point. The size of neutral polyampholytes at the isoelectric pH increases with the increase in the salt concentration. The size of charge excess polyampholytes far away from the isoelectric pH decreases with the increase in the salt concentration.
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A wideband standing wave‐based spectrometer swifts for the 22‐GHz water‐line detection
Authors: Hemour Simon , Podevin Florence , Xavier Pascal , Rauly Dominique , Benech Pierre , le Coarer Etienne 
Published: November 2010

AbstractA compact spectrometer, in the 19–25 GHz range, named stationary waves integrated Fourier transform spectrometer (SWIFTS) has been designed and used for single‐tone spectrum recovery. The experimental results show a very good agreement with the simulated ones obtained from combined circuit and 2D electromagnetic simulations. The application aims at observing the 22‐GHz water line for astronomical purpose. The SWIFTS is inherently a real‐time spectrometer. Presented results are state‐of‐the‐art results when compared with actual real‐time spectrometry in terms of compactness and acquisition fastness. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:62–65, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25669
On the design of wheel‐shaped fractal antenna
Authors: Kumar Raj , Malathi P. , Sawant K. 
Published: November 2010

AbstractThis article presents the design of a wheel‐shaped wide band fractal antenna. This fractal antenna has been designed on substrate εr = 4.3 and thickness h = 1.53 mm. The new antenna has been fed with coplanar waveguide‐fed. The antenna exhibits the excellent ultrawide bandwidth from 0.95 to 4.495 GHz corresponding 130.21% at S11 < −10 dB. The fractal antenna has been curved from the solid circular patch of 50 mm diameter. The first resonant frequency of this fractal antenna shifted to 1.15 GHz in comparison to 1.64 GHz first resonant frequency of circular disk monopole antenna. This indicates the size reduction of the antenna. The experimental radiation pattern of antenna is nearly omnidirectional. Such type of antenna can be useful for mobile and wireless communication. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:155–158, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25677
A novel concurrent dual‐mode class‐e PA using dual‐band stub tapped transformer
Authors: Chen Wenhua , Li Xiang , Wang Li , Zhang Zhijun , Feng Zhenghe 
Published: November 2010

AbstractA novel concurrent dual‐mode class‐E power amplifier is proposed.Owing to the stub tapped transformer and compensation inductance, a dual‐band output matching network is achieved. Experimental results show the output powers of 38.1 and 38.6 dBm, and the drain efficiency of 63.4% and 65.1% are obtained at 920 MHz and 1200 MHz, respectively. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:171–174, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25684
Nemaline myopathy type 6: Clinical and myopathological features
Authors: Olivé Montse , Goldfarb Lev G. , Lee Hee‐Suk , Odgerel Zagaa , Blokhin Andre , Gonzalez‐Mera Laura , Moreno Dolores , Laing Nigel G. , Sambuughin Nyamkhishig 
Published: November 2010

AbstractNemaline myopathy (NEM) is one of the most common congenital myopathies. A unique subtype, NEM6, maps to chromosome 15q21‐q23 in two pedigrees, but the causative gene has not been determined. We conducted clinical examination and myopathological studies in a new NEM family. Genotyping and gene screening were accomplished by searching known and 18 new candidate genes. The disease started in childhood by affecting proximal and distal muscles and causing slowness of movements. Muscle biopsies showed numerous nemaline rods and core‐like formations. Suggestive linkage to chromosome 15q22‐q23 was established. Genes known to be mutated in NEM or core‐rod myopathy were screened and excluded. No pathogenic mutations were identified in other candidate genes. The disease in this Spanish family was classified as NEM6. It is phenotypically similar and probably allelic to the two previously reported NEM6 pedigrees. Further studies of these families will lead to the identification of the NEM6 gene. Muscle Nerve 42: 901–907, 2010