bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discovery and structural characterization of a small molecule 14-3-3 protein-protein interaction inhibitor
Authors: Zhao Jing , Du Yuhong , Horton John R. , Upadhyay Anup K. , Lou Bin , Bai Yan , Zhang Xing , Du Lupei , Li Minyong , Wang Binghe , Zhang Lixin , Barbieri Joseph T. , Khuri Fadlo R. , Cheng Xiaodong , Fu Haian 
Published: September 2011

The 14-3-3 family of phosphoserine/threonine-recognition proteins engage multiple nodes in signaling networks that control diverse physiological and pathophysiological functions and have emerged as promising therapeutic targets for such diseases as cancer and neurodegenerative disorders. Thus, small molecule modulators of 14-3-3 are much needed agents for chemical biology investigations and therapeutic development. To analyze 14-3-3 function and modulate its activity, we conducted a chemical screen and identified 4-[(2Z)-2-[4-formyl-6-methyl-5-oxo-3-(phosphonatooxymethyl)pyridin-2-ylidene]hydrazinyl]benzoate as a 14-3-3 inhibitor, which we termed FOBISIN (FOurteen-three-three BInding Small molecule INhibitor) 101. FOBISIN101 effectively blocked the binding of 14-3-3 with Raf-1 and proline-rich AKT substrate, 40 kD
a
and neutralized the ability of 14-3-3 to activate exoenzyme S ADP-ribosyltransferase. To provide a mechanistic basis for 14-3-3 inhibition, the crystal structure of 14-3-3
ζ
in complex with FOBISIN101 was solved. Unexpectedly, the double bond linking the pyridoxal-phosphate and benzoate moieties was reduced by X-rays to create a covalent linkage of the pyridoxal-phosphate moiety to lysine 120 in the binding groove of 14-3-3, leading to persistent 14-3-3 inactivation. We suggest that FOBISIN101-like molecules could be developed as an entirely unique class of 14-3-3 inhibitors, which may serve as radiation-triggered therapeutic agents for the treatment of 14-3-3-mediated diseases, such as cancer.
The Signature Effect: Signing Influences Consumption-Related Behavior by Priming Self-Identity
Authors: Kettle Keri L. , Häubl Gerald 
Published: September 2011

Abstract
Evidence from four studies shows that signing one’s name influences consumption-related behavior in a predictable manner. Signing acts as a general self-identity prime that facilitates the activation of the particular aspect of a consumer’s self-identity that is afforded by the situation, resulting in behavior congruent with that aspect. Our findings demonstrate that signing causes consumers to become more (less) engaged when shopping in a product domain they (do not) closely identify with (studies 1 and 2), to identify more (less) closely with in(out)-groups (study 3), and to conform more with (diverge more from) in(out)-groups when making consumption choices in preference domains that are relevant to signaling one’s identity (study 4). We discuss the theoretical and practical implications of these findings.
Psychological Distance and the Dual Role of Price
Authors: Bornemann Torsten , Homburg Christian 
Published: September 2011

Abstract
When evaluating a product, consumers may interpret price information as either an indicator of quality or an indicator of monetary sacrifice. On the basis of construal level theory, we propose that psychological distance alters the weight consumers attach to these opposing roles of price. Four experiments show (1) that from both a temporally and a socially distant perspective, the price–perceived quality relationship is more pronounced; (2) that from a temporally proximal perspective, the price–perceived sacrifice relationship is more pronounced; (3) that these effects stem from differences in the way consumers mentally construe price information; and (4) that when people initially use price to judge a product for distant future consumption, it receives less attention as an indicator of sacrifice in a later evaluation for near future consumption. These findings have implications for prelaunch communication activities and preference elicitation methods such as conjoint analysis.
The impact of manager and top management identification on the relationship between perceived organizational justice and change‐oriented behavior
Authors: Fuchs Sebastian 
Published: September 2011

PurposeThe purpose of this study is threefold: to better understand what predicts individuals pro‐change behavior (PCB) and anti‐change behavior (ACB) during organizational renewal with respect to organizational justice perceptions, given its significance for change intervention success; to identify and empirically test two new foci of organizational identification, namely manager and top management identification (TMID); and to investigate how these two new identification foci affect the relationship between various types of organizational justice and change‐oriented behavior.Design/methodology/approachSurvey data from 137 market research employees on their perceptions of organizational distributive, procedural and interactional justice, manager and TMID and PCB and ACB were collected. Multiple hierarchical regression analysis was used for testing direct relationships between organizational justice and change‐oriented behavior and moderation effects of manager and TMID on these relationships.FindingsThe findings indicate that all types of justice predict PCB and that, in addition, interactional justice perceptions are negatively related to employees' ACB. Neither manager nor TMID had a moderating effect on the relationship between organizational justice and PCB, but both moderated the relationship between distributive justice perceptions and ACB. Moreover, identification with top management moderated the relationship between procedural justice perceptions and ACB.Research limitations/implicationsThe use of self‐reported measures on PCB and ACB may present a too optimistic reflection of people's actual behavior during organizational change based on social desirability considerations in organizational research.Practical implicationsThe findings contribute to a better understanding of how organizations and change agents can foster PCB and what role a psychological bond of employees with managers and an organization's top management can play during change interventions. Specifically, organizational leaders should seek both some professional and personal credentials in order to tap into the positive self‐concept element of identification and also adopt a leadership style during change which is associated with charismatic leadership behaviors. Scholars in the areas of organizational behavior and I/O psychology benefit from this study as it sheds light on the antecedents of PCB and ACB and offers two new identification foci that interact with the variables at hand.Originality/valueThe creation of manager and TMID as new foci in organizational identification research and their use as a moderating force on the relationship between both PCB and ACB is unprecedented.
Poverty as a transient reality in a globalised world: an economic choice
Authors: Slabbert A.D. , Ukpere W.I. 
Published: September 2011

PurposePoverty is indeed a terrible monster confronting humanity today. It is alarming and, indeed, not without despair to note that 22,000 children under five die every day as a result of poverty. Thus, in a calendar year, more than eight million children do not progress past the age of five years. One of the world's worst atrocities, which has endured in the minds and hearts of humanity, was the Holocaust, in which six million people were murdered. It continues to be viewed with indignation and revulsion. Bizarrely, the deaths of eight million innocents pass without notice, without indignation and revulsion, and with very few tears being shed. Does this mean that in maybe 50 years from now, we will be condemned as mass murderers, and mentioned in the same context as Hitler's murderers? It is necessary to take note of this. It is necessary to consider our own personal position vis‐à‐vis this reality and take moral decisions. This paper aims to address this issue.Design/methodology/approachThe paper is a meta‐analysis, which relied on secondary sources of information. It is a qualitative study which is based on conceptual analysis, theory building, and the emic perspective (authors' viewpoint).FindingsHumanity is entrusted with the wellbeing and survival of our planet and its inhabitants, and we have definitive custodian responsibilities to exercise. In the final analysis, the hallmark of a successful life is the ability to say: I have left this earth a better place than when I arrived. If poverty is left unchecked, will we be able to make that statement with a clear and untroubled conscience?Social implicationsThere is indeed a solution to global poverty. In order to reach this desired state of affairs, there is just one requirement: international commitment and willingness to change the current status quo. This is not negotiable, but a necessary and sufficient ingredient for change. The rest is detail and can be achieved through a process of hard work, involvement, and essentially, empathy.Originality/valueThis paper is valuable because it confronts one of the disgusting issues affecting humankind today – poverty. Poverty cannot be eradicated if we stand akimbo watching without addressing it. This piece of treatise is an effort by the authors to address it, and proffer possible ways to tackle the malady.
An economic analysis of sports performance in Africa
Authors: Manuel Luiz John , Fadal Riyas 
Published: September 2011

PurposeThe purpose of this study is to develop insight into the socio‐economic determinants of African sports performance. Previous studies have argued that a country's success in sports is directly related to the economic resources that are available for those sports. However, factors that are used to determine the levels of success for developed countries are not necessarily the same, or bear the same weight, as for developing countries.Design/methodology/approachThe premise of this study is to identify specific factors that increase success in sports in developing countries by means of several econometric specifications using cross sectional data for African countries.FindingsThis study finds evidence that suggests that Africa's performance in sports is dependent on a range of socio‐economic factors, which in some respects confirms worldwide studies. Money does indeed matter: GDP was the overwhelmingly consistent dependent variable in all four models tested. Interestingly, important shades of distinction between the various dependent variables are found.Originality/valueThere is a lack of research in the field of sports and organizational economics especially in emerging countries. Previous studies have treated countries as a homogeneous grouping and allowed the broad aggregates to reveal the determinants. This study focuses on a sub‐group of countries that are relatively poor, have had a complex past with colonial masters, and that generally have weak administrative structures.
Financial implications of implementing an e‐learning project
Authors: Sharma Kunal 
Published: September 2011

PurposeThis paper aims to outline the financial implications, while deploying information and communication technologies for implementing e‐learning, and to elucidate them, while implementing an e‐learning project in a conventional university environment.Design/methodology/approachThe paper is a descriptive account of the various cost factors and benefits accrued in implementing an e‐learning project and draws on a variety of secondary sources both published and unpublished.FindingsThe paper identifies the various cost factors as well as the benefits involved in e‐learning implementation in conventional educational institutions, so that e‐learning implementation is a smooth process. Three modes of e‐learning exist, namely, substantially online mode; replacement mode; and supplemental mode, and the costs of e‐learning vary for each. The paper also describes how to assess the success or failure of an e‐learning project.Research limitations/implicationsThe paper presents a review of literature developed from secondary sources since e‐learning implementation is in a budding stage in conventional universities, particularly in the Asian context.Practical implicationsThe paper outlines the financial implications of e‐learning and provides information on the various cost factors in implementing an e‐learning project for the first time. These factors should be duly acknowledged and given consideration, if the advantages of e‐learning are to be fully realised and e‐learning implementation is to succeed.Originality/valueThis paper provides a valuable summary of the state of affairs of financial implications, for instance the cost factors and benefits accrued while implementing an e‐learning project in the case of conventional universities. From this summary of the current situation, it goes on to suggest potential ways to transform the “digital divide” into “digital opportunities”.
A practical application of SurveyMonkey as a remote usability‐testing tool
Authors: Symonds Emily 
Published: September 2011

PurposeThe aim of this paper is to discuss the application of a web‐based tool as a remote asynchronous usability testing method based on an assessment of an academic library's digital collections website.Design/methodology/approachThe paper examines the selection of an asynchronous remote usability testing method, the reasons for the selection of SurveyMonkey, an evaluation of its effectiveness through an assessment of the digital collections web site, and the potential for its application in future usability studies.FindingsSurveyMonkey can be employed as an assessment tool with advance planning by evaluators to capture the responses and opinions of users. Overall, it is a cost effective and time‐saving option for small assessment projects.Research limitations/implicationsThis was an informal study where a specific product, SurveyMonkey, was tested with the purpose of evaluating its effectiveness as a remote asynchronous assessment tool through its application for a specific website usability study. The assessment was not compared to other testing methods, and the tool was not evaluated through formal methods.Practical implicationsLibraries and other organizations can look to free, or low‐cost, web‐based tools as an alternative to more traditional methods, such as focus groups, when evaluating services.Originality/valueThe paper describes the creation and implementation of a web‐based usability test for a library website using a specific product. It looks at the effectiveness of the assessment tool based on cost and time requirements, in addition to the benefits and disadvantages of conducting remote usability testing.
Designing the reverse supply chain: the impact of the product residual value
Authors: Gobbi Chiara 
Published: September 2011

PurposeThe purpose of this paper is to explore the impact of the product residual value (PRV) and the loss of value over time of returned products in the reverse supply chain configuration. It also examines whether or not the distinction of Fisher's functional and innovative products holds for the reverse supply chain.Design/methodology/approachIn order to identify the relevance of the Fisher model, the model needs to be recast in terms of PRV, which, in this context, is considered the independent variable in the reverse logistics arena. Products defined as innovative in Fisher's taxonomy correspond to disposed products with high residual value, whereas functional products correspond to disposed products with low residual value. Furthermore, the PRV and the speed at which returned products lose their value are considered in order to determine the configuration of the reverse supply chain that allows for recapturing most of the PRV. These notions have then been tested by analyzing two reverse supply chains with a case study research methodology.FindingsThe findings show that low PRV is associated with second‐class recovery options (recycling and energy recovery) and that high PRV is associated with first‐class recovery options (reconditioning and remarketing). When the recovery option is recycling, time is not relevant, the primary objective is cost reduction (efficiency), the chain is centralized, and actors and phases of the reverse chain are determined by the specificity of the recycling process. When the recovery option is reconditioning, time is primarily relevant, tradeoffs between costs and time efficiency are necessary, the chain presents a centralized structure, and the presence of other types of actors and phases influences the structure of the reverse supply chain.Research limitations/implicationsThe focus is restricted to the industry of electrical and electronic products.Practical implicationsBased on the outcome of the study, managers are able to determine the basic prerequisites for the design of their reverse supply chains.Originality/valuePrevious literature suggests that when the PRV is high, early product differentiation is necessary, and the chain is therefore decentralized. The paper demonstrates that this is not confirmed in the case of low returned volumes and high reconditioning quality standards.
A cybernetic analysis of a university‐wide curriculum innovation
Authors: Millwood Richard , Powell Stephen 
Published: September 2011

PurposeThis paper seeks to describe and analyse an approach to course design as part of a strategic, technology‐inspired, cross‐university intervention to widen participation. A curriculum framework was developed for students who wished to make their work the focus of their study and could not readily access current university provision. A deliberate assumption was made that this would require a technologically inspired response to teaching, learning and assessment.Design/methodology/approachThe approach taken was one of action research, by planning the curriculum framework, validating a course, delivery and review through interviews. Cybernetics was applied post‐hoc to analyse the data generated.FindingsStaff found the framework a useful source of inspiration and critique for current practices, although established practice and preconceptions could render the framework meaningless. The ideas in the framework are not enough to change the institution – authoritative sanction may be needed. The cybernetic concepts of variety and its absorption proved useful in analysing the framework, and highlighted weaknesses in the design of the framework regarding the organisation of teaching.Research limitations/implicationsClarity about strategic purpose when making a change intervention is vital – in this instance raising the level of critical debate was more successful than recruitment. The establishment of an independent unit may be a more successful strategy than embedding university‐wide. Further work is required to understand how to market novel approaches. The action research shows that the university has the capability to develop curriculum designs that offer new groups of students access to higher education while improving their work practice.Originality/valueThe findings from interview confirm the value that peers attach to this development. Although the pedagogical design in this action research is based on previous work, the cybernetic analysis and conclusions are new.
Service‐oriented architecture and curriculum transformation at Manchester Metropolitan University
Authors: Stubbs Mark , Range Phil 
Published: September 2011

PurposeThe need to establish more flexible and adaptable university curricula has been recognised as a strategic priority in recent years and has been supported by a number of initiatives including the Curriculum Design and Delivery programme funded by the Joint Information System Committee (JISC) in the UK. The challenges of addressing flexibility of curriculum design are both technical and pedagogical. Manchester Metropolitan University has been developing an integrated, institution‐wide virtual learning environment (VLE) since 2006 and this paper seeks to consider the impact of this system.Design/methodology/approachA case study is used to illustrate how one institution has developed and integrated a curriculum design system.FindingsBy adopting a streamlined technology strategy the university can provide learners with personalized and flexible access to the university's resources from the range of different devices and contexts (whether mobile, VLE, or social software) in which learners may find themselves as they engage with their education.Originality/valueA need to establish more flexible and adaptable university curricula is a strategic priority for academic institutions. This case study provides an insight into how one institution is achieving this.
Efficacy and safety of infliximab vs. methotrexate in patients with moderate-to-severe plaque psoriasis: results of an open-label, active-controlled, randomized trial (RESTORE1)
Authors: Barker J. , Hoffmann M. , Wozel G. , Ortonne J.-P. , Zheng H. , van Hoogstraten H. , Reich K. 
Published: September 2011

Summary
Background Infliximab is indicated for treatment of moderate-to-severe plaque psoriasis in adults whose disease cannot be controlled with other systemic therapies, including methotrexate (MTX). To date, no studies have directly compared the efficacy and safety of infliximab and MTX.
Objectives To compare the efficacy and safety of infliximab vs. MTX in adults with moderate-to-severe plaque psoriasis.
Methods MTX-naïve patients (n =868) were randomized 3 : 1 to receive infliximab 5 mg kg−1 at weeks 0, 2, 6, 14 and 22 or MTX 15 mg weekly with a dose increase to 20 mg weekly at week 6 if the Psoriasis Area and Severity Index (PASI) response was &lt; 25%. At week 16, patients with &lt; PASI 50 response could switch treatment groups. The primary efficacy endpoint was PASI 75 response at week 16. Major secondary efficacy endpoints were PASI 75 response at week 26, and the proportion of patients achieving a Physician’s Global Assessment (PGA) score of cleared (0) or minimal (1) at weeks 16 and 26. Others included Dermatology Life Quality Index, 36-Item Short Form Health Survey, and PGA, PASI 50, PASI 75 and PASI 90 responses over time.
Results The primary endpoint was achieved by a significantly greater proportion of infliximab-treated patients (508/653, 78%) than MTX-treated patients (90/215, 42%; P &lt;0·001). Key secondary endpoints also were achieved by a greater proportion of infliximab-treated patients. Similar responses were observed at week 26 in patients who switched from MTX to infliximab at week 16. Overall adverse event (AE) incidence was comparable between groups, but incidence of serious and severe AEs was slightly higher in the infliximab group.
Conclusions Infliximab was well tolerated and more efficacious than MTX in patients with moderate-to-severe plaque psoriasis. Infliximab also was efficacious in patients who failed MTX and switched to infliximab.
Usability problem identification in culturally diverse settings
Authors: Clemmensen Torkil 
Published: September 2011

AbstractThere are indications that established methods for evaluating information system usability that have been developed for use in, e.g. Europe or the USA, fail to give reliable results in countries such as India, China or Malaysia. This paper presents the theoretical background, related work and a definition of culture that should be useful for studies of multiple‐country usability testing. This includes a discussion of cultural fit and the consequences of cultural (in)consistencies between stakeholders in system development and use. As an illustrative example of the kind of academic research that needs to be done, a pilot study is described. The pilot study exemplifies themes to explore, who should be participants and where should the study be done, how to find examples of multiple‐country usability testing, how to collect data and how to analyse that data and what kind of results and discussion of results that may be expected. The conclusion summarises the paper, discusses the limitations of the pilot study and gives detailed suggestions to future research.