bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peak study: A phase 3, randomized, open-label multi-center clinical study of bezuclastinib (CGT9486) and sunitinib combination versus sunitinib in patients with gastrointestinal stromal tumors (GIST).
Authors: Tap William D. , Somaiah Neeta , Kang Yoon-Koo , Abdul Razak Albiruni Ryan , Garrido Marcelo , Desar Ingrid M.E. , Italiano Antoine , Reichardt Peter , Wilky Breelyn A. , Heinrich Michael C. , Druta Mihaela , Singh Arun S. , Attia Steven , Bauer Sebastian , Serrano Cesar , Moynihan Kevin , Lawrence Julia , Wagner Andrew J. , Trent Jonathan C. 
Published: June 2024

TPS11588 Background: Imatinib is the worldwide standard for first-line therapy of advanced KIT-mutant GIST. However, secondary resistance mutations in the KIT ATP-binding domain (exons 13, 14), activation loop (exons 17, 18), or both develop and result in loss of imatinib-sensitivity. Bezuclastinib has a highly selective inhibition profile, leading to minimal off-target toxicities and allowing for combination with sunitinib. While no single tyrosine kinase inhibitor (TKI) inhibits all KIT mutations, the combination of bezuclastinib + sunitinib targets commonly occurring primary (exons 9, 11) and secondary (exons 13, 14, 17, and 18) KIT mutations and may provide more durable responses. The early signs of clinical activity, tolerability, and safety observed with the combination thus far in Peak Part 1 (Somaiah et al. [presentation] CTOS 2023. Paper 62) are consistent with the completed Phase 1/2 study (PLX121-01). Methods: Peak (NCT05208047) is a global, randomized, open-label, multi-part Phase 3 study evaluating the efficacy and safety of bezuclastinib + sunitinib versus sunitinib as second-line treatment in adult pts who were intolerant to imatinib or whose tumors had imatinib-resistance. Current Peak study sites are located in North America (3 countries), South America (3 countries), Europe (12 countries), and Asia-Pacific (4 countries). The lead-in portion to test a new formulation of bezuclastinib, (Part 1) completed enrollment in April 2023. Based upon PK and safety, a dose of bezuclastinib 600 mg QD + sunitinib 37.5 mg QD was determined for Part 2 of the Peak study. Part 2 will enroll ~388 pts to be randomized (1:1) to bezuclastinib 600 mg QD + sunitinib 37.5 mg QD or sunitinib 37.5 mg QD alone. Key inclusion: >1 measurable lesion per modified Response Evaluation Criteria in Solid Tumors (mRECIST) v1.1, Eastern Cooperative Oncology Group Performance Status 0-2, adequate organ function, and prior imatinib therapy (no other prior therapy). Key exclusion: known PDGFR mutations or succinate dehydrogenase deficiency, clinically significant cardiac disease, and use of strong CYP3A4 inhibitors or inducers. The primary endpoint is progression-free survival (PFS) confirmed by blinded independent central review per mRECIST v1.1. Additional efficacy (including overall survival and objective response rate) and safety endpoints will be evaluated and circulating tumor DNA (ctDNA) will be collected and assessed. Clinical trial information: NCT05208047 .
Trigger Warning
Authors: Herzig Rebecca M. 
Published: May 2024

Abstract
Trigger warnings, statements alerting readers, listeners, or viewers to the presence of content that might revive distressing memories, have become a flash point in recent discussions about the US academy. Providing a genealogy of the concept and practice in US colleges and universities, this article situates the trigger warning's growing cultural prominence within twined changes in computer-mediated communication and legal understandings of embodied consent. Seen against this backdrop of racialized, gendered struggles over the meanings of free, voluntary action, the trigger warning debate helps illuminate how the normative regimes of the contemporary university reflect the long afterlife of US racial slavery.
Solving the Minimum Sum Coloring Problem: Alternative Models, Exact Solvers, and Metaheuristics
Authors: Du Yu , Glover Fred , Kochenberger Gary , Hennig Rick , Wang Haibo , Hulandageri Amit 
Published: May 2024

The minimum sum coloring problem (MSCP), a well-known NP-hard (nondeterministic polynomial time) problem with important practical applications, has been the subject of several papers in recent years. Because of the computational challenge posed by these problems, most solution methods employed are metaheuristics designed to find high-quality solutions with no guarantee of optimality. Exact methods (like Gurobi) and metaheuristic solvers have greatly improved in recent years, enabling high-quality and often optimal solutions to be found to a growing set of MSCPs. Alternative model forms can have a significant impact on the success of exact and heuristic methods in such settings, often providing enhanced performance compared with traditional model forms. In this paper, we introduce several alternative models for MSCP, including the quadratic unconstrained binary problem plus (QUBO-Plus) model for solving problems with constraints that are not folded into the objective function of the basic quadratic unconstrained binary problem (QUBO) model. We provide a computational study using a standard set of test problems from the literature that compares the general purpose exact solver from Gurobi with the leading QUBO metaheuristic solver NGQ and a special solver called Q-Card that belongs to the QUBO-Plus class. Our results highlight the effectiveness of the QUBO and QUBO-Plus models when solved with these metaheuristic solvers on this test bed, showing that the QUBO-Plus solver Q-Card provides the best performance for finding high-quality solutions to these important problems. History: Accepted by Pascal Van Hentenryck, Area Editor for Computational Modeling: Methods & Analysis. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2022.0334 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2022.0334 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .
The efficacy of Topical Clascoterone versus systematic spironolactone for treatment of acne vulgaris: A systematic review and network meta-analysis
Authors: Basendwh Mohammad A. , Alharbi Amer Abdulaziz , Bukhamsin Sarah Abdulla , Abdulwahab Rahaf Abdulrashid , Alaboud Sarah Abdullah 
Published: May 2024

Objectives
This study aimed to evaluate the effectiveness of topical clascoterone (TC) compared to oral spironolactone for acne vulgaris treatment.

Methods
A computerized search through PubMed/MEDLINE, SCOPUS, and the Cochrane Library was conducted to find relevant papers. We used the "netmeta" and "meta" packages for network meta-analysis (NMA) in RStudio 1.2.5019 (2009–2019 RStudio, Inc.) to conduct all of our statistical tests.

Results
Seven articles (n = 2,006 patients) were included. The fixed-effect size showed that TC 1% bis in die (BID) showed potential effectiveness in reducing the inflammatory and non-inflammatory lesion count compared to placebo (Standardized mean difference, SMD = -0.27, 95% CI: -0.36 to -0.17) and (SMD = -0.31, 95% CI: -0.41 to -0.22), respectively. The random-effect size showed that TC 1% BID was significantly associated with a 12-week treatment success compared to placebo (Odds ratio, OR = 2.44, 95% CI: 1.12 to 5.30). Spironolactone 200 mg was associated with a significant reduction in total lesion count (SMD = -4.46, 95% CI: -5.60 to -3.32).

Conclusion
TC appears to reduce both inflammatory and non-inflammatory lesion count and may lead to treatment success. Spironolactone at 200 mg showed potential effectiveness in terms of total lesion count reduction. These results suggest that both TC and Spironolactone could be beneficial in treating patients with acne vulgaris.
The association of caffeine intake and prevalence of obesity among children and adolescents: A cross-sectional survey from NHANES 2011–2020 March
Authors: Liu Zi Rui , Cui Kai 
Published: June 2024

BackgroundMany studies have demonstrated the beneficial health effects of caffeine. However, its association with obesity prevalence and caffeine intake remains controversial. Notably, the impact of caffeine on children and adolescents needs to be more adequately represented in large-scale epidemiological investigations.ObjectiveThis study examines the association between caffeine intake and obesity prevalence in children and adolescents aged 2 to 19.MethodsThis study used the database from the National Health and Nutrition Examination Survey (NHANES, 2011–2020 March) to perform a cross-sectional study. A total of 10,001 classified children and adolescents were included in this analysis. All data were survey-weighted, and corresponding logistic regression models were performed to examine the associations between caffeine intake and the prevalence of obesity.ResultsIn a fully adjusted model, a per-quartile increase in caffeine intake was associated with a 0.05% increased prevalence of obesity. In the subgroup analysis, the multivariate-adjusted ORs (95% CIs) of the prevalence of obesity for per-quartile 1.3497 (1.2014, 1.5163) increments in caffeine intake were 1.5961 (1.3127, 1.9406) for boys and 1.4418 (1.1861, 1.7525) for girls, 1.5807 (1.3131, 1.9027) for white race and 1.3181 (1.0613, 1.6370), 1.0500 (0.6676, 1.6515) for the age of 2–5, 1.4996 (1.1997, 1.8745) for the age of 6–12, and 1.2321 (0.9924, 1597) for the age of 13–19.ConclusionThe study suggested that higher caffeine intake may have a protective effect against obesity in specific subgroups, particularly among no overweight individuals. However, the association was not significant in other groups, indicating the need for a nuanced understanding of caffeine’s impact on obesity in diverse populations.
Leukocytoclastic Vasculitis-Associated Myocarditis as an Extraintestinal Manifestation of Crohn's Disease
Authors: Shibu Roney , Mohsen Waled 
Published: June 2024

ABSTRACTCardiac extraintestinal manifestations (EIMs) of Crohn's disease (CD) are uncommon. They include pericarditis, myocarditis, and arrhythmias; however, distinguishing these from alternative causes including medication-related adverse effects is often challenging. Leukocytoclastic vasculitis is another uncommon EIM of CD that may present with systemic involvement. We present a rare case of myocarditis associated with leukocytoclastic vasculitis occurring as EIMs of CD. The myocarditis proved refractory to standard therapy and biologics targeting underlying gut inflammation. She developed an inflammatory cardiomyopathy and symptoms consistent with heart failure with preserved ejection fraction. Anakinra was tried, but despite the initial response, it should be used cautiously in patients with CD.
Molecular distinctions of bronchoalveolar and alveolar organoids under differentiation conditions
Authors: Yu Yan , Chen Zexin , Zheng Bin , Huang Min , Li Junlang , Li Gang 
Published: June 2024

AbstractThe bronchoalveolar organoid (BAO) model is increasingly acknowledged as an ex‐vivo platform that accurately emulates the structural and functional attributes of proximal airway tissue. The transition from bronchoalveolar progenitor cells to alveolar organoids is a common event during the generation of BAOs. However, there is a pressing need for comprehensive analysis to elucidate the molecular distinctions characterizing the pre‐differentiated and post‐differentiated states within BAO models. This study established a murine BAO model and subsequently triggered its differentiation. Thereafter, a suite of multidimensional analytical procedures was employed, including the morphological recognition and examination of organoids utilizing an established artificial intelligence (AI) image tracking system, quantification of cellular composition, proteomic profiling and immunoblots of selected proteins. Our investigation yielded a detailed evaluation of the morphologic, cellular, and molecular variances demarcating the pre‐ and post‐differentiation phases of the BAO model. We also identified of a potential molecular signature reflective of the observed morphological transformations. The integration of cutting‐edge AI‐driven image analysis with traditional cellular and molecular investigative methods has illuminated key features of this nascent model.
The (almost) integral Chow ring of ℳ̅3
Authors: Pernice Michele 
Published: June 2024

Abstract
This paper is the fourth in a series of four papers aiming to describe the (almost integral) Chow ring of

M
̄

3

\overline{\mathcal{M}}_{3}

, the moduli stack of stable curves of genus 3.
In this paper, we finally compute the Chow ring of

M
̄

3

\overline{\mathcal{M}}_{3}

with

Z
⁢

[

1
/
6

]

\mathbb{Z}[1/6]

-coefficients.
Teachers’ Perceptions of a Chatbot’s Role in School-based Professional Learning
Authors: Beyer Steven , Arndt Kerstin 
Published: May 2024

Abstract
This article focuses on the gap in research concerning the insufficient availability of information and communication technologies for teacher professional learning (TPL) and the consequent scarcity of research on technology acceptance (TA) in TPL. These research gaps are addressed through the implementation of a chatbot designed to support school-based TPL activities. Mathematics teachers and teacher training facilitators (n = 11) were interviewed regarding their TA after testing the chatbot, as a crucial factor for its implementation. The chatbot was developed to assist teachers in structuring planning tasks and facilitating the exploration and application of well-prepared knowledge. Results from qualitative content analysis indicate that this presumed potential of the chatbot can be considered confirmed in the present context. Additionally, four external variables were identified as key evaluation factors, with Perceived Quality standing out as the main reference point for Perceived Usefulness.
Eco-fertility: examining the climate change-total fertility rate nexus in the context of sustainable developmental goals in a systematic review approach
Authors: Sengupta Pallav , Dutta Sulagna 
Published: June 2024

Abstract
Sustainable Development Goals (SDGs) are paramount as the global community confronts the ramifications of climate alterations, especially its implications on population dynamics. Initial studies suggest an intricate relationship between environmental determinants and reproductive choices. This systematic review elucidates the complex interplay between climate-related challenges and observed global fertility rate variations. A comprehensive search and analysis of literature published in the last 10 years (2013–2023), available in the PubMed database, delineates the relationship between environmental changes and fertility patterns in both human and animal populations. The review highlighted significant effects of climatic fluctuations on reproductive health, manifested as either adaptive or maladaptive responses to environmental stressors. This relationship not only influences population trajectories but may also have complications for the SDGs, specifically those pertaining to health, well-being, and gender equality. The study emphasizes the importance of intertwining demographic insights with ecological considerations. A deeper understanding of the nexus between climate and fertility can augment strategies aimed at global sustainability. The synthesized evidence underscores the urgency for further research, which seeks to seamlessly incorporate eco-fertility perspectives into wider climate and sustainability discussions.
Modality and Actuality: Lukács’s Criticism of Hegel in History and Class Consciousness
Authors: Rametta Gaetano 
Published: June 2024

Abstract
The present article tries to show the originality of Lukács’s theory of Actuality (Wirklichkeit) by comparing it with the same notion in Hegel’s Logic. It results that Lukács’s interpretation of Marxism and the Russian Revolution depends on a clear and independent theoretical position with regard to Hegel and his Idealistic theory of Modality. Particular importance is given to the new conception of the Dialectical interplay between the notions of Objective Possibility and Historical Necessity.
Cushing’s disease presenting with recurrent abscesses followed by post-remission hyperthyroidism
Authors: Stogowska Ewa , Łebkowska Agnieszka , Kościuszko Maria , Zieliński Grzegorz , Kowalska Irina , Karczewska-Kupczewska Monika 
Published: June 2024

Summary
We report a case of a 59-year-old woman with Cushing’s disease who developed hyperthyroidism following treatment of hypercortisolaemia. The patient with a history of recurrent hospitalisations caused by multi-sited soft tissue abscesses was admitted with sepsis. Both her medical history and physical examination suggested Cushing’s syndrome. The initial hormonal diagnostic process, conducted after sepsis treatment, brought forth conflicting results. However, hormonal assessment repeated 3 months later indicated pituitary hypercortisolaemia, which was confirmed through bilateral inferior petrosal sinus sampling and was successfully treated with transsphenoidal pituitary surgery. Three months after the surgery, the patient was readmitted to our epartment with symptoms of hyperthyroidism, which was confirmed by laboratory tests. Thyroid scintiscans indicated Graves’ disease. However, the absence of anti-thyroid stimulating hormone antibodies suggested other etiologies of hyperthyroidism. Eventually, the patient underwent radioiodine therapy. Currently, her condition is improving and she has had no recurrence of abscesses, severe infections, or hyperthyroidism. In conclusion, while clinical manifestation of hypercortisolaemia might be non-specific, its treatment may trigger the development of autoimmune diseases.

Learning points

The presence of recurrent severe infections should prompt physicians to consider the possibility of hypercortisolaemia.

Chronic hypercortisolism is debilitating and can lead to significant disability.

Dexamethasone suppression testing in patients with active or recent severe inflammatory or infectious illnesses may produce misleading or confusing results.

Clinicians should be aware of the potential development of autoimmune diseases following successful treatment of hypercortisolaemia.
Advanced facial recognition with LBP-URIGL hybrid descriptors
Authors: Hendi Sajjad H. , Taher Hazeem B. , Hussein Karim Q. 
Published: June 2024

AbstractFacial recognition technology is transformative in security and human-machine interaction, reshaping societal interactions. Robust descriptors, essential for high precision in machine learning tasks like recognition and recall, are integral to this transformation. This paper presents a hybrid model enhancing local binary pattern descriptors for facial representation. By integrating rotation-invariant local binary pattern with uniform rotation-invariant grey-level co-occurrence, employing linear discriminant analysis for feature space optimization, and utilizing an artificial neural network for classification, the model achieves exceptional accuracy rates of 100% for Olivetti Research Laboratory, 99.98% for Maastricht University Computer Vision Test, and 99.17% for Extended Yale B, surpassing traditional methods significantly.
Sacred Landscapes and Wisdom Maps: Keawaʻula's Legacy
Authors: Spencer Kekaha Kalikolehua Pōmaikaʻināmeaapau 
Published: May 2024

In the realm of indigenous knowledge systems, Kanaka researcher and scholar Oliveira's wisdom maps (2019) are a profound means to capture the intangible aspects of our cultural heritage and ancestral knowledge. They serve as metaphorical oral repositories, containing experiential, relational, and historical knowledge, which may not be easily reduced to written form. This essay integrates ethnographic research, historical accounts, and Hawaiian and indigenous knowledge such as moʻolelo (stories, literature, history) to demonstrate the significance of one such wahi pana (celebrated place), Keawaʻula, Oʻahu. The mo'olelo of Hiʻiakaikapoliopele, Pele's younger sister, offers us a rich example of ancestral knowledge and cultural heritage transmission transcending time and place. By tracing Hiʻiaka's journey and her interactions with the landscape of Keawaʻula and its surrounding areas, we gain a deeper understanding of ʻike Hawaiʻi (Hawaiian knowledge) and ʻike kūpuna (ancestral knowledge) through lessons of resilience, transformation, and the potential for positive change in the face of adversity, emphasizing the importance of place and the enduring connection between Hawaiians and 'āina (land). These moʻolelo are not mere relics of the past but vital tools for uplifting ʻike Hawaiʻi and ʻike kūpuna, playing a central role in our indigenous resurgence, preserving the indigeneity of these places. They also reveal their relevance in contemporary contexts inspiring a deeper connection to 'āina (land, that which feeds) by acting as a powerful link between the past, present, and future. Transformation encompasses significant changes in ʻāina and people over time, reflecting our adaptive response to life's challenges, demonstrating the depth of our connection with 'āina. Meanwhile, potential for positive change embodies hopeful anticipation of beneficial outcomes, recognizing every situation as an opportunity for improvement. This paper invites exploration of how wisdom maps reaffirm the importance of mo'olelo and our connection to 'āina, resisting the erasure of our presence from our kulāiwi (homeland). In embracing the insights of our kūpuna, we find pathways to thrive, highlighting the strength and richness ingrained in our heritage and homeland. Hiʻiakaikapoliopele's moʻolelo takes us on a journey through Keawaʻula and its neighboring ahupuaʻa (land divisions), revealing ancestral knowledge crucial for understanding our identity as Kānaka. This example of Kanaka geography illustrates methods used to map ancestral places and retain moʻolelo, shaping our identity and connection with ʻāina (Oliveira, 2019).
Analysis of February 2023 Thatri Landslide in Doda, Jammu and
Kashmir: Insights from Field Observations, Geotechnical Parameters, and GPR
Survey
Authors: Singh Yudhbir , Ul Haq Ahsan , Bhat G.M. , Johar Sumit , Chib Shifali , Pandita S.K. 
Published: June 2024

Abstract
The present study deals with the field observations and results obtained from the Geotechnical investigations and Ground Penetrating Radar survey carried out on Thatri landslide. Thatri township is situated on the left bank of the Chenab River along NH-244, 43 km from district headquarter Doda, Jammu and Kashmir. The landslide occurred on 2nd February, 2023 damaged 21 buildings, affected about 150 people and created situation like Joshimath tragedy. Detailed field investigations on lithology, sub-surface structure determined by GPR investigations and geotechnical parameters of the soil revealed that the leading edge of the slide caused most damage due to cracks developed in the slope wash deposits followed by subsidence and down slope movement of a portion of the township (Nai Basti). The study revealed that percolation of water from soak pits, sewerage, and rain water into the terrace deposits comprising of clays, silt, sand and gravels was the major triggering factors.