bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discovery and Validation of a 15-Gene Prognostic Signature for Clear Cell Renal Cell Carcinoma
Authors: Mehra Rohit , Nallandhighal Srinivas , Cotta Brittney , Knuth Zayne , Su Fengyun , Kasputis Amy , Zhang Yuping , Wang Rui , Cao Xuhong , Udager Aaron M. , Dhanasekaran Saravana M. , Cieslik Marcin P. , Morgan Todd M. , Salami Simpa S. 
Published: May 2024

PURPOSE Develop and validate gene expression–based biomarker associated with recurrent disease to facilitate risk stratification of clear cell renal cell carcinoma (ccRCC). MATERIALS AND METHODS We retrospectively identified 110 patients who underwent radical nephrectomy for ccRCC ( discovery cohort). Patients who recurred were matched on the basis of grade/stage to patients without recurrence. Capture whole-transcriptome sequencing was performed on RNA isolated from archival tissue using the Illumina platform. We developed a gene-expression signature to predict recurrence-free survival/disease-free survival (DFS) using a 15-fold lasso and elastic-net regularized linear Cox model. We derived the 31-gene cell cycle progression (mxCCP) score using RNA-seq data for each patient. Kaplan-Meier (KM) curves and multivariable Cox proportional hazard testing were used to validate the independent prognostic impact of the gene-expression signature on DFS, disease-specific survival (DSS), and overall survival (OS) in two validation data sets (combined n = 761). RESULTS After quality control, the discovery cohort comprised 50 patients with recurrence and 41 patients without, with a median follow-up of 26 and 36 months, respectively. We developed a 15-gene (15G) signature, which was independently associated with worse DFS and DSS (DFS: hazard ratio [HR], 11.08 [95% CI, 4.9 to 25.1]; DSS: HR, 9.67 [95% CI, 3.4 to 27.7]) in a multivariable model adjusting for clinicopathologic parameters (including stage, size, grade, and necrosis [SSIGN] score and Memorial Sloan Kettering Cancer Center nomogram) and mxCCP score. The 15G signature was also independently associated with worse DFS and DSS in both validation data sets (Validation A [n = 382], DFS: HR, 2.6 [95% CI, 1.6 to 4.3]; DSS: HR, 3 [95% CI, 1.4 to 6.1] and Validation B (n = 379), DFS: HR, 2.1 [95% CI, 1.2 to 3.6]; OS: HR, 3 [95% CI, 1.6 to 5.7]) adjusting for clinicopathologic variables and mxCCP score. CONCLUSION We developed and validated a novel 15G prognostic signature to improve risk stratification of patients with ccRCC. Pending further validation, this signature has the potential to facilitate optimal treatment allocation.
Telling late-time tails for a massive scalar field in the background of brane-localized black holes
Authors: Dubinsky Alexey 
Published: May 2024

Abstract
We examine perturbations of a massive scalar field around spherically symmetric, brane-localized black holes. Although the ringdown and asymptotic tails of various brane-world black holes have been extensively studied, there has been no analysis of the massive late-time tails for the simplest Schwarzschild-like, brane-localized black hole to date. We demonstrate that after the ringdown phase, two stages of oscillatory tails emerge —intermediate and asymptotic. The asymptotic decay law is distinct from those associated with Schwarzschild or Reissner-Nordström solutions. Specifically, during intermediate times, the signal decays as

, while the asymptotic decay law is

.
Novel Detection and Progression Markers for Diabetes Based on Continuous Glucose Monitoring Data Dynamics
Authors: Montaser Eslam , Farhy Leon S , Kovatchev Boris P 
Published: May 2024

Abstract

Context
Static measures of continuous glucose monitoring (CGM) data, such as time spent in specific glucose ranges (70-180 mg/dL or 70-140 mg/dL), do not fully capture the dynamic nature of blood glucose, particularly the subtle gradual deterioration of glycemic control over time in individuals with early-stage type 1 diabetes.

Objective
Develop a diabetes diagnostic tool based on 2 markers of CGM dynamics: CGM entropy rate (ER) and Poincaré plot (PP) ellipse area (S).

Methods
A total of 5754 daily CGM profiles from 843 individuals with type 1, type 2 diabetes, or healthy individuals with or without islet autoantibody status were used to compute 2 individual dynamic markers: ER (in bits per transition; BPT) of daily probability matrices describing CGM transitions between 8 glycemic states, and the area S (mg2/dL2) of individual CGM PP ellipses using standard PP descriptors. The Youden index was used to determine “optimal” cut-points for ER and S for health vs diabetes (case 1); type 1 vs type 2 (case 2); and low vs high type 1 immunological risk (case 3). The markers’ discriminative power was assessed through the area under the receiver operating characteristics curves (AUC).

Results
Optimal cutoff points were determined for ER and S for each of the 3 cases. ER and S discriminated case 1 with AUC = 0.98 (95% CI, 0.97-0.99) and AUC = 0.99 (95% CI, 0.99-1.00), respectively (cutoffs ERcase1 = 0.76 BPT, Scase1 = 1993.91 mg2/dL2), case 2 with AUC = 0.81 (95% CI, 0.77-0.84) and AUC = 0.76 (95% CI, 0.72-0.81), respectively (ERcase2 = 1.00 BPT, Scase2 = 5112.98 mg2/dL2), and case 3 with AUC = 0.72 (95% CI, 0.58-0.86), and AUC = 0.66 (95% CI, 0.47-0.86), respectively (ERcase3 = 0.52 BPT, Scase3 = 923.65 mg2/dL2).

Conclusion
CGM dynamics markers can be an alternative to fasting plasma glucose or glucose tolerance testing to identify individuals at higher immunological risk of progressing to type 1 diabetes.
The Burning of Bédoin
Authors: Clarke Joseph 
Published: May 2024

AbstractOn May 28, 1794, a criminal investigation that had begun almost a month before concluded with the execution of sixty-three men and women, the imprisonment of fifteen more, and a few days later the destruction of an entire village. This article examines the burning of Bédoin, the crime that provoked it, and the judicial process that accompanied it, to explore the relationship between criminal cause and punitive effect during the Terror of year II. As a case study in revolutionary justice, this episode appears extreme, but this article argues that it allows us to interrogate the meanings that ordinary revolutionaries attached to terms like crime and complicity when the survival of the state seemed at stake. In looking beyond the Terror to the controversies that enveloped this village's destruction, this article also examines the aftermath of atrocity to consider how a society comes to terms with crime when both the definition of criminality and the identity of the criminal are in flux.
The Algerian Enemy Within
Authors: Beaujon Danielle 
Published: May 2024

Abstract
During World War II police officers in Marseille and Algiers relentlessly hunted Algerian black market operatives. Hundreds of reports from these two cities detail the actions taken to prevent individuals from selling contraband goods, exceeding fixed market prices, or ignoring rationing protocols. Long-standing colonial stereotypes had labeled Algerians as prone to theft and violence, but the economic restrictions of war created a new category of the imagined Algerian criminal: the black market trafficker. In police reports the figure of the Algerian profiteer is omnipresent, but internal communications acknowledged that Europeans profited from the black market, too. Why, then, the fixation on Algerians? This article argues that police developed a narrative of Algerians as “internal enemies” of France. Their underlying suspicion of Algerians endured throughout World War II even as governments rose and fell in France and loyalties of the entire nation shifted. In treating Algerians as threats to national security, the police justified a system of control that homogenized the Algerian community along racial lines. The racialized policing of “anti-French” Algerian traffickers built not just on visual codes of race but also on how police practice mapped ideas of race onto the space of the city.
Anthony Trollope's Formal Experiment: Repetition and the Anti-romantic Marriage Plot
Authors: Lewis Christian 
Published: May 2024

Abstract
In Miss Mackenzie, Anthony Trollope attempted to write a marriage plot without love or romance but admitted that he was unable to do so. This essay argues that Trollope's formal experiment developing the “anti-romantic” marriage plot did not end with Miss Mackenzie but continued across eighteen novels written from 1864 to 1876. The essay performs a midrange reading of this set of novels to argue that across this experiment Trollope iterates his anti-romantic marriage plot, replicating his central conflict and establishing three stock characters (moral maidens, hesitating heroines, and husband hunters). Trollope's experiment clashed against his own gender and class politics, forcing him to confront and reevaluate his own ideas and gradually empathize with women who choose to marry not for romance but for financial security. While Trollope's novels have, since their publication, been criticized as repetitious, the essay argues that his use of repetition is not a weakness but a strength, a formal tactic with unique affordances. This reframing offers a way to reconsider Trollope's literary technique and prodigious output as well as appreciate the impact that his experiment had on the trajectory of the Victorian realist novel. While the 1860s and 1870s are often considered the peak of Victorian high realism, Trollope's novels (and the influence they have on other major novelists) reveal how during these decades the marriage plot and realism itself was in crisis.
Institutional Context Shapes the Physical Health of College Graduates Differently for U.S. White, Black, and Hispanic Adults
Authors: Gaydosh Lauren , Harris Kathleen Mullan 
Published: May 2024

Abstract
Greater educational attainment is generally associated with healthier and longer lives. However, important heterogeneity in who benefits from educational attainment, how much, and why remains underexplored. In particular, in the United States, the physical health returns to educational attainment are not as large for minoritized racial and ethnic groups compared with individuals racialized as White. Yet, our current understanding of ethnoracial differences in educational health disparities is limited by an almost exclusive focus on the quantity of education attained without sufficient attention to heterogeneity within educational attainment categories, such as different institution types among college graduates. Using biomarker data from the National Longitudinal Study of Adolescent to Adult Health (Add Health), we test whether the physical health of college graduates in early adulthood (aged 24–32) varies by institution type and for White, Black, and Hispanic adults. In considering the role of the college context, we conceptualize postsecondary institutions as horizontally stratified and racialized institutional spaces with different implications for the health of their graduates. Finally, we quantify the role of differential attendance at and returns to postsecondary institution type in shaping ethnoracialized health disparities among college graduates in early adulthood.
Antibiotic-Impregnated Ventriculoperitoneal Shunts Decrease Bacterial Shunt Infection: A Systematic Review and Meta-Analysis
Authors: Kovács Janka , Máté Vanda , Obeidat Mahmoud , Nagy Rita , Agócs Gergely , Kiss-Dala Szilvia , Hegyi Péter , Kiss-Miki Renáta , Párniczky Andrea , Müller Katalin E. , Garami Miklós 
Published: May 2024

BACKGROUND AND OBJECTIVES:
Antibiotic-impregnated shunts seem to be beneficial in preventing bacterial infections and decreasing mortality by effectively inhibiting microbial growth in the shunt system and reducing the risk of shunt-associated infections. This study aimed to evaluate the efficacy of antibiotic-impregnated shunt catheters (AISC) in reducing the incidence of bacterial shunt infection in patients with hydrocephalus.

METHODS:
The protocol was registered on PROSPERO. A meta-analysis was conducted by searching 3 databases (PubMed, Scopus, CENTRAL) for relevant randomized controlled trials and observational studies. We included all studies published until November 2022 in any language. The primary outcome was the rate of bacterial infections, whereas the rate of shunt failure was our secondary endpoint. Odds ratios (OR) with 95% CI were calculated using a random-effects model.

RESULTS:
A total of 27 articles with 27 266 shunt operations were included in this study. The results indicated that using AISC is significantly associated with reduction in infections (OR = 0.42; 95% CI: 0.33-0.54). Regarding shunt failure, there was a tendency in favor of AISC use (OR = 0.73; 95% CI: 0.51-1.06).

CONCLUSION:
Our study provided evidence that AISC is significantly associated with the reduction in the rate of bacterial ventriculoperitoneal-shunt infection. In addition, there was a tendency toward AISC to decrease shunt failure compared with the standard shunt.
Maternal mental health and breastfeeding duration: the role of optimism and coping strategies
Authors: Bacon Alison M , Norman Alyson , Mason Eleanor 
Published: May 2024

Background/Aims Mental health can influence the likelihood that a woman will initiate and continue breastfeeding behaviour that is associated with improved infant and maternal health. Mental health outcomes are associated with variables such as optimism and coping. The aim of this study was to explore the relationship between coping, optimism and mental health, and their impact on breastfeeding duration. Methods A total of 612 women who had breastfed completed an online questionnaire comprising the hospital anxiety and depression scale, cognitive emotional regulation questionnaire, brief coping orientation to problems experienced inventory and life orientation test. Data were analysed using correlations, ordinal linear regression and mediation analysis. Results There was a direct relationship between breastfeeding duration and depression but no direct relationship between duration and anxiety. A mediation analysis showed no mediating between breastfeeding duration and depression. Optimism did mediate the relationship between anxiety and duration, with optimism being associated with reduced anxiety and increased duration. Conclusions The findings highlight the importance of support for mothers while breastfeeding to improve mental health outcomes and foster coping strategies, such as optimism.
Real-world adolescent smartphone use is associated with improvements in mood: An ecological momentary assessment study
Authors: Minich Matt , Moreno Megan 
Published: May 2024

Objective
Rates of adolescent mood disorders and adolescent smartphone use have risen in parallel, leading some to suggest that smartphone use might have detrimental effects on adolescents’ moods. Alternatively, it is possible that adolescents turn to smartphone use when experiencing negative mood. The purpose of this study was to explore the relationship between adolescent smartphone use and mood using a longitudinal methodology that measured both in real-time.

Method
This study used an Ecological Momentary Assessment (EMA) procedure completed by 253 12-17-year old participants from across the United States. Participants received short surveys delivered to their smartphones at random points throughout the day. Measures included real-time, in-situ assessments of smartphone use, current mood, and mood before smartphone use.

Results
Based on tests of a multilevel regression model, adolescent moods were positively associated with smartphone use (β = 0.261, F(1,259.49) = 19.120, p < 0.001), and that mood was positively associated with the length of phone use sessions (length of phone use β = 0.100, F(1, 112.88) = 5.616, p = 0.020). Participants also reported significant changes in mood during phone use, such that moods before phone use were significantly lower than moods during phone use (MChange = 0.539, t(2491) = 23.174, p < 0.001). Change in mood (mood before minus mood during phone use) was positively associated with the length of smartphone use sessions (β = 0.097, F(1,122.20) = 4.178, p = 0.043), such that participants who had a higher change in mood were more likely to report a longer length of smartphone use.

Conclusions
Findings suggest that adolescent smartphone use is positively associated with mood. This finding may suggest that adolescents use smartphones for mood modification, which aligns with an understanding of smartphone use as potentially addictive behavior.
Entomological assessment of hessian fabric transfluthrin vapour emanators for protecting against outdoor-biting Aedes aegypti in coastal Tanzania
Authors: Govella Nicodem J. , Assenga Alphonce , Mlwale Amos T. , Mirzai Nosrat , Heffernan Eimear , Moriarty Jennie , Wenger John , Corbel Vincent , McBeath Justin , Ogoma Sheila B. , Killeen Gerry F. 
Published: May 2024

Background
A low technology emanator device for slowly releasing vapour of the volatile pyrethroid transfluthrin was recently developed in Tanzania that provides robust protection against night biting Anopheles and Culex vectors of malaria and filariasis for several months. Here these same emanator devices were assessed in Dar es Salaam city, as a means of protection against outdoor-biting Aedes (Stegomia) aegypti, the most important vector of human arboviruses worldwide, in parallel with similar studies in Haiti and Brazil.

Methods
A series of entomological experiments were conducted under field and semi-field conditions, to evaluate whether transfluthrin emanators protect against wild Ae. aegypti, and also compare the transfluthrin responsiveness of Ae. aegypti originating from wild-caught eggs to established pyrethroid-susceptible Ae. aegypti and Anopheles gambiae colonies. Preliminary measurements of transfluthrin vapour concentration in air samples collected near treated emanators were conducted by gas chromatography-mass spectrometry.

Results
Two full field experiments with four different emanator designs and three different transfluthrin formulations consistently indicated negligible reduction of human landing rates by wild Ae. aegypti. Under semi-field conditions in large cages, 50 to 60% reductions of landing rates were observed, regardless of which transfluthrin dose, capture method, emanator placement position, or source of mosquitoes (mildly pyrethroid resistant wild caught Ae. aegypti or pyrethroid-susceptible colonies of Ae. aegypti and An. gambiae) was used. Air samples collected immediately downwind from an emanator treated with the highest transfluthrin dose (15g), contained 12 to 19 μg/m3 transfluthrin vapour.

Conclusions
It appears unlikely that the moderate levels of pyrethroid resistance observed in wild Ae. aegypti can explain the modest-to-undetectable levels of protection exhibited. While potential inhalation exposure could be of concern for the highest (15g) dose evaluated, 3g of transfluthrin appears sufficient to achieve the modest levels of protection that were demonstrated entomologically. While the generally low levels of protection against Aedes reported here from Tanzania, and from similar entomological studies in Haiti and Brazil, are discouraging, complementary social science studies in Haiti and Brazil suggest end-users perceive valuable levels of protection against mosquitoes. It therefore remains unclear whether transfluthrin emanators have potential for protecting against Aedes vectors of important human arboviruses.
Meningeal contrast enhancement in multiple sclerosis: Assessment of field strength, acquisition delay, and clinical relevance
Authors: Harrison Daniel M. , Allette Yohance M. , Zeng Yuxin , Cohen Amanda , Dahal Shishir , Choi Seongjin , Zhuo Jiachen , Hua Jun 
Published: May 2024

Background/Purpose
Leptomeningeal enhancement (LME) on post-contrast FLAIR is described as a potential biomarker of meningeal inflammation in multiple sclerosis (MS). Here we report an assessment of the impact of MRI field strength and acquisition timing on meningeal contrast enhancement (MCE).

Methods
This was a cross-sectional, observational study of 95 participants with MS and 17 healthy controls (HC) subjects. Each participant underwent an MRI of the brain on both a 7 Tesla (7T) and 3 Tesla (3T) MRI scanner. 7T protocols included a FLAIR image before, soon after (Gd+ Early 7T FLAIR), and 23 minutes after gadolinium (Gd+ Delayed 7T FLAIR). 3T protocol included FLAIR before and 21 minutes after gadolinium (Gd+ Delayed 3T FLAIR).

Results
LME was seen in 23.3% of participants with MS on Gd+ Delayed 3T FLAIR, 47.4% on Gd+ Early 7T FLAIR (p = 0.002) and 57.9% on Gd+ Delayed 7T FLAIR (p < 0.001 and p = 0.008, respectively). The count and volume of LME, leptomeningeal and paravascular enhancement (LMPE), and paravascular and dural enhancement (PDE) were all highest for Gd+ Delayed 7T FLAIR and lowest for Gd+ Delayed 3T FLAIR. Non-significant trends were seen for higher proportion, counts, and volumes for LME and PDE in MS compared to HCs. The rate of LMPE was different between MS and HCs on Gd+ Delayed 7T FLAIR (98.9% vs 82.4%, p = 0.003). MS participants with LME on Gd+ Delayed 7T FLAIR were older (47.6 (10.6) years) than those without (42.0 (9.7), p = 0.008).

Conclusion
7T MRI and a delay after contrast injection increased sensitivity for all forms of MCE. However, the lack of difference between groups for LME and its association with age calls into question its relevance as a biomarker of meningeal inflammation in MS.
Impact of integrative care on cardiovascular disease risk in newly diagnosed type 2 diabetes mellitus patients: A BI-VitalLife Cohort study
Authors: Khunlertkit Tanawat , Viangteeravat Teeradache , Wangprapa Panupong , Siriwechdaruk Suthee , Ford Jeremy Mark , Pongpirul Krit 
Published: May 2024

Introduction
Type 2 diabetes mellitus (T2DM), a chronic metabolic disorder, significantly increases cardiovascular disease (CVD) risk. Integrative care (IC) offers a personalized health management approach, utilizing various interventions to mitigate this risk. However, the impact of IC on CVD risk in newly diagnosed T2Dm patients remains unclear. This study aims to assess the differences in CVD risk development within 120 months following a new diagnosis of T2DM, using real-world data from Bumrungrad International Hospital and Vitallife Scientific Wellness Center.

Methods
This study utilized the BI-VitalLife Cohort dataset that contains de-identified demographics, vitals, diagnoses and clinical information, laboratory and radiological data, medications, and treatments of more than 2.8 million patients who visited Bumrungrad International Hospital and/or VitalLife Scientific Wellness Center from June 1, 1999, to May 31, 2022. This study focused on newly diagnosed T2DM patients, defined according to American Diabetes Association criteria. We compared CVD risk between the IC and conventional care (CC) groups using the Kaplan-Meier curve and Cox proportional hazard model, adjusted for age, sex, and laboratory values. Propensity score matching was employed to enhance comparability.

Results
Of the 5,687 patients included, 236 were in the IC group and 5,451 in the CC group. The IC group, characterized by a lower age at T2DM diagnosis, showed favorable hematological and metabolic profiles. The Cox proportional hazard ratios revealed a significantly lower CVD risk in the IC group within 120 months post-T2DM diagnosis compared to the CC group, consistent even after adjusting for confounding factors. Propensity score-matched analysis supported these findings.

Conclusion
Personalized integrative care may offer a significant advantage in reducing CVD risk among newly diagnosed T2DM patients compared to conventional care, even when considering various confounding factors. This study sheds light on the potential of integrative care in informing treatment strategies for T2DM patients at risk of developing CVD.