bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linking information technology use with corporate entrepreneurship: The mediation role of openness to external knowledge
Authors: Cao Chuhan , Chen Meng , Tang Xinlin , Liu Hefu 
Published: May 2024

AbstractFirms are increasingly applying multiple information technologies (ITs) to pursue corporate entrepreneurship. However, how different ITs can be leveraged collectively to achieve corporate entrepreneurship remains largely underexplored. Drawing upon the knowledge‐based view, we develop an integrative theoretical model to delineate how three types of commonly deployed IT (i.e. organisational enterprise systems use, organisational social media use and top management team social media use) can be used collectively in the knowledge acquisition and utilisation processes to achieve corporate entrepreneurship. Specifically, we posit that organisational IT uses (i.e. organisational enterprise systems use and organisational social media use) enhance openness to external knowledge in the knowledge acquisition process, which in turn serves as the mediation mechanism to channel organisational IT uses into corporate entrepreneurship. Moreover, top management team IT use (i.e. top management team social media use) shapes the effect of openness to external knowledge on corporate entrepreneurship in the knowledge utilisation process. The empirical analysis using multi‐respondent survey data from 1252 managers in 313 firms provides strong support for the proposed model. This study contributes to the information systems research on how IT influences corporate entrepreneurship by distinguishing the roles of organisational enterprise systems use, organisational social media use and top management team social media use in enhancing corporate entrepreneurship through firms' openness to external knowledge.
A protocol for a systematic review of social dimensions of resilience in older adults
Authors: Soares Mantere Eerik , Rostgaard Tine , Timonen Virpi , Perek‐Białas Jolanta 
Published: May 2024

AbstractBackgroundPopulations are ageing, making the quality of old age a crucial issue. Some adversity in old age, such as loss of loved one or loss of physical function, is often experienced, as is the need for recovery from such adversity. Resilience in later life has become an important topic and has accumulated much empirical research. However, the research has mainly centred on individual factors, such as personality, rather than social factors, such as family relationships or community engagement. There is no systematic review of the social dimensions of resilience in old age, a focus that should be especially important for policy and practice seeking to create supporting environments.MethodsOur review comprises quantitative and qualitative empirical original English language studies, published 2013–2023, using predefined search phrases including ‘resilience’ and various terms for old age and social dimensions. Titles and abstracts are screened by the first two authors using registered exclusion criteria. Final inclusion, based on full‐text reading, is decided using registered inclusion criteria, and verified by co‐authors. Qualitative articles are read by authors specialized in qualitative research and quantitative articles by authors specialized in quantitative research. Due to large expected heterogeneity, meta‐analysis is not conducted, but weighted effect sizes or funnel plots may be prepared if parallel quantitative studies are encountered. Qualitative studies are synthesized using meta‐aggregation. The risk of bias is evaluated with applicable Joanna Briggs Institute checklists for each study design. A narrative synthesis brings together the qualitative and quantitative studies.ConclusionMethodological strengths and weaknesses of the included studies are reported to assess the quality of the research. Summary of the most significant social dimensions of resilience in old age is prepared, emphasizing interactions between contexts, stressors, mechanisms and outcomes; and research gaps are identified.Systematic Review RegistrationProtocol is registered in PROSPERO (CRD42023412532).
Contemporary trends of leadless pacemaker implantation in the United States
Authors: Khan Muhammad Z. , Nassar Sameh , Nguyen Amanda , Khan Muhammad Usman , Sattar Yasar , Alruwaili Waleed , Gonuguntla Karthik , Mazek Haitham , Asad Zain Ul Abideen , Agarwal Siddharth , Raina Sameer , Balla Sudarshan , Nguyen Bao , Fan Dali , Darden Douglas , Munir Muhammad Bilal 
Published: May 2024

AbstractIntroductionLeadless pacemakers (LPM) have established themselves as the important therapeutic modality in management of selected patients with symptomatic bradycardia. To determine real‐world utilization and in‐hospital outcomes of LPM implantation since its approval by the Food and Drug Administration in 2016.MethodsFor this retrospective cohort study, data were extracted from the National Inpatient Sample database from the years 2016−2020. The outcomes analyzed in our study included implantation trends of LPM over study years, mortality, major complications (defined as pericardial effusion requiring intervention, any vascular complication, or acute kidney injury), length of stay, and cost of hospitalization. Implantation trends of LPM were assessed using linear regression. Using years 2016−2017 as a reference, adjusted outcomes of mortality, major complications, prolonged length of stay (defined as >6 days), and increased hospitalization cost (defined as median cost >34 098$) were analyzed for subsequent years using a multivariable logistic regression model.ResultsThere was a gradual increased trend of LPM implantation over our study years (3230 devices in years 2016−2017 to 11 815 devices in year 2020, p for trend <.01). The adjusted mortality improved significantly after LPM implantation in subsequent years compared to the reference years 2016−2017 (aOR for the year 2018: 0.61, 95% CI: 0.51−0.73; aOR for the year 2019: 0.49, 95% CI: 0.41−0.59; and aOR for the year 2020: 0.52, 95% CI: 0.44−0.62). No differences in adjusted rates of major complications were demonstrated over the subsequent years. The adjusted cost of hospitalization was higher for the years 2019 (aOR: 1.33, 95% CI: 1.22−1.46) and 2020 (aOR: 1.69, 95% CI: 1.55−1.84).ConclusionThe contemporary US practice has shown significantly increased implantation rates of LPM since its approval with reduced rates of inpatient mortality.
Molecular and functional characterization of reversible‐sunitinib‐tolerance state in human renal cell carcinoma
Authors: Zaccagnino Angela , Vynnytska‐Myronovska Bozhena , Stöckle Michael , Junker Kerstin 
Published: May 2024

AbstractTherapy failure with the tyrosine kinase inhibitor (TKI) sunitinib remains a great challenge in metastatic renal cell carcinoma (mRCC). Growing evidence indicates that the tumour subpopulation can enter a transient, non‐mutagenic drug‐tolerant state to endure the treatment underlying the minimal residual disease and tumour relapse. Drug tolerance to sunitinib remains largely unexplored in RCC. Here, we show that sunitinib‐tolerant 786‐O/S and Caki‐2/S cells are induced by prolonged drug treatment showing reduced drug sensitivity, enhanced clonogenicity, and DNA synthesis. Sunitinib‐tolerance developed via dynamic processes, including (i) engagement of c‐MET and AXL pathways, (ii) alteration of stress‐induced p38 kinase and pro‐survival BCL‐2 signalling, (iii) extensive actin remodelling, which was correlated with activation of focal adhesion proteins. Remarkably, the acute drug response in both sensitive and sunitinib‐tolerant cell lines led to dramatic fine‐tuning of the actin‐cytoskeleton and boosted cellular migration and invasion, indicating that the drug‐response might depend on cell state transition rather than pre‐existing mutations. The drug‐tolerant state was transiently acquired, as the cells resumed initial drug sensitivity after >10 passages under drug withdrawal, reinforcing the concept of dynamic regulation and phenotypic heterogeneity. Our study described molecular events contributing to the reversible switch into sunitinib‐tolerance, providing possible novel therapeutic opportunities in RCC.
Prognostic and immunotherapeutic implications of bilirubin metabolism‐associated genes in lung adenocarcinoma
Authors: Ren Kangqi , Ling Xiean , Chen Lin , Li Zeyao , Huang Tonghai 
Published: May 2024

AbstractLung adenocarcinoma (LUAD) is a major subtype of non‐small‐cell lung cancer and accompanies high mortality rates. While the role of bilirubin metabolism in cancer is recognized, its specific impact on LUAD and patient response to immunotherapy needs to be elucidated. This study aimed to develop a prognostic signature of bilirubin metabolism‐associated genes (BMAGs) to predict outcomes and efficacy of immunotherapy in LUAD. We analysed gene expression data from The Cancer Genome Atlas (TCGA) to identify survival‐related BMAGs and construct a prognostic model in LUAD. The prognostic efficacy of our model was corroborated by employing TCGA‐LUAD and five Gene Expression Omnibus datasets, effectively stratifying patients into risk‐defined cohorts with marked disparities in survival. The BMAG signature was indeed an independent prognostic determinant, outperforming established clinical parameters. The low‐risk group exhibited a more favourable response to immunotherapy, highlighted by increased immune checkpoint expression and immune cell infiltration. Further, somatic mutation profiling differentiated the molecular landscapes of the risk categories. Our screening further identified potential drug candidates preferentially targeting the high‐risk group. Our analysis of critical BMAGs showed the tumour‐suppressive role of FBP1, highlighting its suppression in LUAD and its inhibitory effects on tumour proliferation, migration and invasion, in addition to its involvement in cell cycle and apoptosis regulation. These findings introduce a potent BMAG‐based prognostic indicator and offer valuable insights for prognostication and tailored immunotherapy in LUAD.
Improved therapeutic effects on vascular intimal hyperplasia by mesenchymal stem cells expressing MIR155HG that function as a ceRNA for microRNA‐205
Authors: Bai Xiao , Qi Zaiwen , Cai Chuanliang , Song Hao , Song Guangmin , Zhao Xin 
Published: May 2024

AbstractCoronary artery bypass grafting (CABG) is an effective treatment for coronary heart disease, with vascular transplantation as the key procedure. Intimal hyperplasia (IH) gradually leads to vascular stenosis, seriously affecting the curative effect of CABG. Mesenchymal stem cells (MSCs) were used to alleviate IH, but the effect was not satisfactory. This work aimed to investigate whether lncRNA MIR155HG could improve the efficacy of MSCs in the treatment of IH and to elucidate the role of the competing endogenous RNA (ceRNA). The effect of MIR155HG on MSCs function was investigated, while the proteins involved were assessed. IH was detected by HE and Van Gieson staining. miRNAs as the target of lncRNA were selected by bioinformatics analysis. qRT‐PCR and dual‐luciferase reporter assay were performed to verify the binding sites of lncRNA‐miRNA. The apoptosis, Elisa and tube formation assay revealed the effect of ceRNA on the endothelial protection of MIR155HG‐MSCs. We observed that MIR155HG improved the effect of MSCs on IH by promoting viability and migration. MIR155HG worked as a sponge for miR‐205. MIR155HG/miR‐205 significantly improved the function of MSCs, avoiding apoptosis and inducing angiogenesis. The improved therapeutic effects of MSCs on IH might be due to the ceRNA role of MIR155HG/miR‐205.
Validation of the pink esthetic score/white esthetic score at single tooth‐supported prostheses in the esthetic zone: A randomized clinical trial
Authors: Dash Sreeprada , Srivastava Gunjan , Padhiary Subrat Kumar , Samal Monika , Çakmak Gülce , Roccuzzo Andrea , Molinero‐Mourelle Pedro 
Published: May 2024

AbstractObjectivesTo validate the reproducibility and inter/intra‐observer variability of the Pink Esthetic Score/White Esthetic Score (PES/WES) of single tooth‐supported prostheses in the maxillary esthetic zone (13–23).Materials and MethodsForty‐five patients were randomly assigned to one of the three treatment options (15 patients per group) receiving each one a different crown type: Porcelain fused to metal (PFM), monolithic zirconia, and lithium disilicate. Eight observers from each of four different specialties (Prosthodontists, Orthodontists, Periodontists, and Oral Surgeons) were recruited and assessed twice and four weeks apart (i.e., T1 and T2) 45 photographs of the single tooth‐supported prosthesis using PES/WES and compared them with contralateral teeth.ResultsAccording to the ANOVA and post hoc tests, the zirconia crown type obtained the highest mean score by all observers, with a mean value of 16.70 ± 2.94. The prosthodontists and oral surgeons assigned the lowest mean score to PFM crowns, 13.03 ± 3.47 and 13.80 ± 3.17, respectively. Notably, the prosthodontists awarded the highest scores, specifically 17.50 ± 2.81 for the zirconia crowns. Intraobserver agreement was calculated utilizing the paired t‐test. Pairwise comparisons between observers of different specialties revealed significant intraobserver agreement. Interclass correlation coefficient (ICC) scores were statistically significant among four specialties. No difference was detected concerning the interobserver agreement.ConclusionsThe PES/WES index remains consistent across various observers from different specializations, yielding uniform results in the overall esthetic evaluation. Consequently, in light of the presented preliminary positive results, its use might also be considered for the esthetic assessment of single‐tooth‐supported prostheses.Clinical SignificanceThe PES/WES index may be employed clinically to evaluate single tooth‐supported prostheses as it emerged as a reproducible esthetic scoring system.
Development and evaluation of a modified most probable number (MPN) method for enumerating rifampicin‐resistant Escherichia coli in agricultural, food, and environmental samples
Authors: Gao Zhujun , Jha Aprajeeta , Hudson Claire L. , Hopper Adam L. , Micallef Shirley A. , Tikekar Rohan V. 
Published: May 2024

AbstractLow level of rifampicin‐resistant E. coli is frequently used in food safety research as a model microorganism and is typically enumerated using traditional Most Probable Number (MPN) method. To simplify the process, we developed and validated a modified MPN method based on lactose peptone broth (LPB) containing rifampicin and bromocresol purple, the broth changes to a yellow color due to pH shifts induced by lactose fermentation from E. coli. E. coli TVS353 were prepared in following suspensions including healthy cells, injured cells, competitive bacteria with or without rifampicin resistance, and unknown natural microflora. E. coli TVS353 was quantified by traditional MPN method and our improved method. At a predicted level of 1 log CFU/mL, there was no significant difference in the MPN index of LPBR compared with TSB and TSBR in these suspensions (p > 0.05). Confirmation results generated from this new color change MPN method were analogous to traditional MPN methods.
Long chain unsaturated fatty acids alter growth and reduce biofilm formation of Cronobacter sakazakii
Authors: Phair Katie , Culliton David , Kealey Carmel , Brady Damien 
Published: May 2024

AbstractCronobacter sakazakii is a foodborne pathogen predominately transmitted through contaminated dried foods and affects populations including neonates, infants, and the elderly. Following several recent outbreaks, it is now a notifiable infection in those under 12 months of age. Current control methods include strict manufacturing guidelines, with monitoring of this genus a legal requirement in powdered infant formula production. Fatty acids have long been known as antimicrobials, with long‐chain fatty acids increasingly identified as agents that target virulence factors. This study gives insight into the changes promoted by three long‐chain unsaturated fatty acids (oleic, linoleic, and α‐linolenic) on C. sakazakii growth, morphology, and biofilm formation. Each fatty acid was individually introduced to C. sakazakii 29544 both as a sole carbon source and as an addition to complex media. Following comparison to the untreated control, bacterial cells treated with these fatty acids showed a significant and media‐dependent impact on growth and biofilm inhibition. With further characterization, long‐chain fatty acids, including α‐linolenic acid, could be utilized as a control method with minimal safety constraints regarding their use in the food production environment.
A vicinal oxygen chelate protein facilitates viral infection by triggering the unfolded protein response in Nicotiana benthamiana
Authors: Guo Zhihong , Jiang Ning , Li Menglin , Guo Hongfang , Liu Qi , Qin Xinyu , Zhang Zongying , Han Chenggui , Wang Ying 
Published: May 2024

ABSTRACTVicinal oxygen chelate (VOC) proteins are members of an enzyme superfamily with dioxygenase or non‐dioxygenase activities. However, the biological functions of VOC proteins in plants are poorly understood. Here, we show that a VOC in Nicotiana benthamiana (NbVOC1) facilitates viral infection. NbVOC1 was significantly induced by infection by beet necrotic yellow vein virus (BNYVV). Transient overexpression of NbVOC1 or its homolog from Beta vulgaris (BvVOC1) enhanced BNYVV infection in N. benthamiana, which required the nuclear localization of VOC1. Consistent with this result, overexpressing NbVOC1 facilitated BNYVV infection, whereas, knockdown and knockout of NbVOC1 inhibited BNYVV infection in transgenic N. benthamiana plants. NbVOC1 interacts with the basic leucine zipper transcription factors bZIP17/28, which enhances their self‐interaction and DNA binding to the promoters of unfolded protein response (UPR)‐related genes. We propose that bZIP17/28 directly binds to the NbVOC1 promoter and induces its transcription, forming a positive feedback loop to induce the UPR and facilitating BNYVV infection. Collectively, our results demonstrate that NbVOC1 positively regulates the UPR that enhances viral infection in plants.
Mortality in French people with polyhandicap/profound intellectual and multiple disabilities
Authors: Hamouda I. , Baumstarck K. , Aim M.‐A. , Beltran Anzola A. , Loundou A. , Billette de Villemeur T. , Boyer L. ,   the EVAL‐PLH group, Auquier P. , Rousseau M.‐C. 
Published: May 2024

AbstractBackgroundIn recent decades, progress has been made in the care of people with polyhandicap/profound intellectual and multiple disabilities (PIMD) through a better understanding of the pathophysiology and the development of new care management and rehabilitation strategies adapted to these extreme pathologies. Although there is a lack of knowledge about the health status and care management of the oldest people, a better understanding of the natural course of life of people with polyhandicap/PIMD would consequently allow the optimisation of preventive and curative care management strategies. Few robust data on mortality and life expectancy have been documented for this population in France. Our aims are to estimate the median survival time and assess the factors associated with mortality in people with polyhandicap/PIMD receiving care in France.MethodsThis study included people with polyhandicap/PIMD, followed by the French national cohort ‘Eval‐PLH’ since 2015. These individuals were included in specialised rehabilitation centres and residential institutions. The people included in the first wave of the cohort (2015–2016) were eligible for the present study. Vital status on 1 January 2022 (censoring date) was collected in two ways: (1) spontaneous reporting by the participating centre to the coordinating team and (2) systematic checking on the French national death platform. According to the vital status, survival was calculated in years from the date of birth to the date of death or from the date of birth to the censoring date. The factors associated with mortality were evaluated using the Cox proportional regression hazards model.ResultsData from 780 individuals aged between 3 and 67 years were analysed. At the censoring date, 176 (22.6%) had died, and the mean survival was 52.8 years (95% confidence interval: 51.1–54.5). Mortality was significantly associated with a progressive aetiology, recurrent pulmonary infections, drug‐resistant epilepsy and a higher number of medical devices.ConclusionsThis study shows for the first time the survival and impact of factors associated with mortality in people with polyhandicap/PIMD in France.
Complications of collagen biostimulators in Brazil: Description of products, treatments, and evolution of 55 cases
Authors: Ianhez Mayra , de Goés e Silva Freire Giselle , Sigrist Rosa Maria Silveira , Colpas Paula Tavares , de Faria Isabella Alves , Parada Meire Odete Américo Brasil , Miot Hélio Amante 
Published: May 2024

AbstractBackgroundComplications of temporary and permanent fillers have been extensively studied. However, there is a lack of comparative data regarding poly‐L‐lactic acid (PLLA), calcium hydroxyapatite (CaHA), and polycaprolactone (PCL) known as collagen biostimulators.AimsThis study addressed the complications of collagen biostimulators concerning their diagnosis, type of product, treatment, and monitoring.Patients/MethodsAn electronic questionnaire was sent to Brazilian dermatologic ultrasound experts to identify complications related to biostimulators. The type of biostimulator, location of application, number of vials injected, application plan, time between injection treatment and complication, injector profile, treatment, and prognosis were assessed.ResultsFifty‐five cases were identified, of which 49.1% were caused by PLLA‐Elleva®, 23.6% by CaHA (alone or combined with hyaluronic acid), 20.0% by PLLA‐Sculptra®, and 7.3% by PCL. The most affected area was the face (72.7%), with nodules being the most common clinical form (89.1%), generally occurring late (60.0%) (>1 month). Only one case was injected at an incorrect depth (musculoaponeurotic system—SMAS). Despite several treatments, including saline (45.5%), hyaluronidase (25.5%), diluted corticosteroids (23.6%), and energy‐based devices (10.9%), only five cases showed complete resolution. Hyaluronidase was beneficial in complications related to fillers when there was an association of calcium hydroxyapatite with hyaluronic acid (p < 0.01).ConclusionsComplications from collagen biostimulators were more common on the face, typically manifesting about 1 month after treatment. These issues seemed to be related more to the properties of the products rather than inadequate technique. Furthermore, hyaluronidase demonstrated efficacy only in cases where there was an association with HA.