bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementasi Edukasi yang Dipimpin Perawat (Nurse-Led) Terhadap Kualitas Hidup Pasien dengan Penyakit Jantung Koroner: Systematic Review
Authors: Aprilia Nita , Nurachmah Elly , Maria Riri 
Published: May 2024

ABSTRACT Patient management that is led, organized, and carried out by nurses or Nurse-led is proven to be able to improve self-management, prevent rehospitalizations and improve the quality of life in coronary heart disease (CHD) patients. It is necessary to review further the educational interventions provided to improve the quality of life in CHD patients. The aim of this study was to determine the effect of nurse-led educational interventions to improve the quality of life in CHD patients. Systematic review of four databases: PubMed, Scopus, ProQuest and ScienceDirect. Articles spanning the last 10 years with experimental designs were searched. Education led by nurses to explain quality of life in CHD patients is mostly long term, namely more than 6 months. However, all of them can significantly improve the quality of life of CHD patients with significance values of p<0.05 and p<0.001. Nurse-led education has proven to be effective in improving the quality of life in CHD patients. Future research is expected to develop the implementation of continuous nurse-led education to improve functional capacity and quality of life and further reduce the number of disability-adjusted life years (DALYs) in CHD patients. Keywords: Coronary Heart Disease; Coronary Artery Disease; Acute Coronary Syndrome; Myocardial Infarction; Angina; Percutaneous Coronary Intervention ABSTRAK Pengelolaan pasien yang dipimpin, diatur dan dilakukan oleh perawat atau nurse-led terbukti dapat meningkatkan manajemen diri, mencegah kejadian rawat inap berulang dan meningkatkan kualitas hidup pada pasien dengan penyakit jantung koroner (PJK), perlu ditinjau lebih lanjut terkait implementasi edukasi yang diberikan untuk dapat meningkatkan kualitas hidup pada pasien PJK. Tujuan dari penelitian ini adalah untuk mengetahui implementasi edukasi yang dipimpin oleh perawat untuk meningkatkan kualitas hidup pada pasien PJK. Systematic review pada empat database: PubMed, Scopus, ProQuest dan ScienceDirect. Artikel dalam rentang waktu 10 tahun terakhir dengan desain eksperimental ditelusuri. Edukasi yang dipimpin oleh perawat untuk peningkatkan kualitas hidup pada pasien PJK sebagian besar bersifat jangka panjang, yaitu lebih lebih dari 6 bulan. Meskipun demikian, seluruhnya secara signifikan dapat meningkatkan kualitas hidup pasien PJK dengan nilai signifikansi yaitu p<0,05 dan p<0,001. Edukasi yang dipimpin perawat (nurse-led) terbukti efektif untuk meningkatan kualitas hidup pada pasien PJK. Penelitian selanjutnya diharapkan dapat mengembangkan implementasi edukasi yang dipimpin oleh perawat secara berkesinambungan untuk meningkatkan kapasitas fungsional dan kualitas hidup serta lebih lanjut menurunkan angka disability-adjusted life years (DALYs) pada pasien PJK. Kata kunci: Penyakit jantung koroner; Penyakit arteri koroner; Sindrom Koroner Akut; Infark Miokard; Angina; Intervensi Koroner Perkutan.
Impact of focused wave groups on pier structures: a case study of severe breaking waves at Pont del Petroli during storm Gloria
Authors: Altomare Corrado , Gironella Xavier , Marzeddu Andrea , Viñes Recasens Manuel , Mösso Cesar , Sospedra Joaquim 
Published: May 2024

In January 2020, the footbridge connecting the seaward platform of the Pont del Petroli pier to Badalona beach collapsed due to the severe sea storm named Gloria. Approximately 15 m of the footbridge fell into the sea as a result of prolonged wave action and strong impacts. To understand the complex interaction between waves and structures that led to the pier’s collapse during the storm, a composite modelling approach was developed. The loads on each pier element were initially evaluated using the meshless DualSPHysics code, which employs the Smoothed Particle Hydrodynamics (SPH) method. This evaluation was conducted under severe wave conditions analogous to those experienced during the storm. Numerical models informed the design of an experimental campaign carried out at the Maritime Engineering Laboratory of Universitat Politècnica de Catalunya—BarcelonaTech, using the CIEM large-scale wave flume facility in Barcelona, Spain. Post-storm bathymetric surveys revealed significant alterations in the seabed profile near the affected infrastructure, including sediment deposition and a reduction in water depth from 10 m to 8 m. Consequently, it was anticipated that wave transformation and breaking in the vicinity of the structure would be substantially affected. To explore this phenomenon, various extreme wave impacts were experimentally simulated using focused wave groups. The physical model findings unveiled the forces that the pier endured during the storm Gloria. The results indicate that wave phases influence individual waves, with waves that are biased and asymmetric experiencing higher peaks than those focused on the crest. This insight helps to explain the structural failure of the footbridge during the storm and underscores the importance of considering wave phase impacts in the design and assessment of coastal infrastructure. The combined numerical and experimental approach provides a comprehensive understanding of the forces at play, contributing valuable knowledge to the field of coastal engineering and infrastructure resilience.
Casual associations of thyroid function with inflammatory bowel disease and the mediating role of cytokines
Authors: Wu Shuyun , Yi Jiazhi , Wu Bin 
Published: May 2024

BackgroundPrevious observational epidemiological studies have suggested a potential association between thyroid function and inflammatory bowel disease (IBD). However, the findings remain inconclusive, and whether this association is causal remains uncertain. The objective of this study is to investigate the causal association between thyroid function and IBD.MethodsGenome-wide association studies (GWAS) involving seven indicators of thyroid function, IBD, and 41 cytokines were analyzed. Bidirectional two-sample Mendelian randomization (MR) and multivariable MR were conducted to examine the causal relationship between thyroid function and IBD and to explore the potential mechanisms underlying the associations.ResultsGenetically determined hypothyroidism significantly reduced the risk of CD (odds ratio [OR] = 0.761, 95% CI: 0.655–0.882, p &lt; 0.001). Genetically determined reference-range TSH was found to have a suggestive causal effect on IBD (OR = 0.931, 95% CI: 0.888–0.976, p = 0.003), (Crohn disease) CD (OR = 0.915, 95% CI: 0.857–0.977, p = 0.008), and ulcerative colitis (UC) (OR =0.910, 95% CI: 0.830–0.997, p = 0.043). In reverse MR analysis, both IBD and CD appeared to have a suggestive causal effect on the fT3/fT4 ratio (OR = 1.002, p = 0.013 and OR = 1.001, p = 0.015, respectively). Among 41 cytokines, hypothyroidism had a significant impact on interferon-inducible protein-10 (IP-10) (OR = 1.465, 95% CI: 1.094–1.962, p = 0.010). The results of multivariable MR showed that IP-10 may mediate the causal effects of hypothyroidism with CD.ConclusionOur results suggest that an elevated TSH level reduces the risk of CD, with IP-10 potentially mediating this association. This highlights the pituitary-thyroid axis could serve as a potential therapeutic strategy for CD.
Exploratory metabolomic analysis for characterizing the metabolic profile of the urinary bladder under estrogen deprivation
Authors: Zhang Wei , Yang Qingbo , Song Yingying , Liu Wenheng , Li Yao 
Published: May 2024

BackgroundEstrogen homeostasis is crucial for bladder function, and estrogen deprivation resulting from menopause, ovariectomy or ovarian dysfunction may lead to various bladder dysfunctions. However, the specific mechanisms are not fully understood.MethodsWe simulated estrogen deprivation using a rat ovariectomy model and supplemented estrogen through subcutaneous injections. The metabolic characteristics of bladder tissue were analyzed using non-targeted metabolomics, followed by bioinformatics analysis to preliminarily reveal the association between estrogen deprivation and bladder function.ResultsWe successfully established a rat model with estrogen deprivation and, through multivariate analysis and validation, identified several promising biomarkers represented by 3, 5-tetradecadiencarnitine, lysoPC (15:0), and cortisol. Furthermore, we explored estrogen deprivation-related metabolic changes in the bladder primarily characterized by amino acid metabolism imbalance.ConclusionThis study, for the first time, depicts the metabolic landscape of bladder resulting from estrogen deprivation, providing an important experimental basis for future research on bladder dysfunctions caused by menopause.
Rare taxa mediate microbial carbon and nutrient limitation in the rhizosphere and bulk soil under sugarcane–peanut intercropping systems
Authors: Fu Yue , Tang Xiumei , Sun Tingting , Lin Litao , Wu Lixue , Zhang Tian , Gong Yifei , Li Yuting , Wu Haining , Xiong Jun , Tang Ronghua 
Published: May 2024

IntroductionMicrobial carbon (C) and nutrient limitation exert key influences on soil organic carbon (SOC) and nutrient cycling through enzyme production for C and nutrient acquisition. However, the intercropping effects on microbial C and nutrient limitation and its driving factors between rhizosphere and bulk soil are unclear.MethodsTherefore, we conducted a field experiment that covered sugarcane–peanut intercropping with sole sugarcane and peanut as controls and to explore microbial C and nutrient limitation based on the vector analysis of enzyme stoichiometry; in addition, microbial diversity was investigated in the rhizosphere and bulk soil. High throughput sequencing was used to analyze soil bacterial and fungal diversity through the 16S rRNA gene and internal transcribed spacer (ITS) gene at a phylum level.ResultsOur results showed that sugarcane–peanut intercropping alleviated microbial C limitation in all soils, whereas enhanced microbial phosphorus (P) limitation solely in bulk soil. Microbial P limitation was also stronger in the rhizosphere than in bulk soil. These results revealed that sugarcane-peanut intercropping and rhizosphere promoted soil P decomposition and facilitated soil nutrient cycles. The Pearson correlation results showed that microbial C limitation was primarily correlated with fungal diversity and fungal rare taxa (Rozellomycota, Chyltridiomycota, and Calcarisporiellomycota) in rhizosphere soil and was correlated with bacterial diversity and most rare taxa in bulk soil. Microbial P limitation was solely related to rare taxa (Patescibacteria and Glomeromycota) in rhizosphere soil and related to microbial diversity and most rare taxa in bulk soil. The variation partitioning analysis further indicated that microbial C and P limitation was explained by rare taxa (7%–35%) and the interactions of rare and abundant taxa (65%–93%).ConclusionThis study indicated the different intercropping effects on microbial C and nutrient limitation in the rhizosphere and bulk soil and emphasized the importance of microbial diversity, particularly rare taxa.
Clinical and prognostic implications of hyaluronic acid in patients with COVID-19 reinfection and first infection
Authors: Li Yanyan , Han Ming , Li Xin 
Published: May 2024

ObjectivePrevious research has shown that human identical sequences of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) promote coronavirus disease 2019 (COVID-19) progression by upregulating hyaluronic acid (HA). However, the association of HA with mortality and long COVID in SARS-CoV-2 reinfection and first infection is unclear.MethodsPatients with COVID-19 at Beijing Ditan Hospital from September 2023 to November 2023 were consecutively enrolled. SARS-CoV-2 reinfections were matched 1:2 with first infections using a nearest neighbor propensity score matching algorithm. We compared the hospital outcomes between patients with COVID-19 reinfection and first infection. The association between HA levels and mortality and long COVID in the matched cohort was analyzed.ResultsThe reinfection rate among COVID-19 hospitalized patients was 25.4% (62 cases). After propensity score matching, we found that reinfection was associated with a better clinical course and prognosis, including lower levels of C-reactive protein and erythrocyte sedimentation rate, fewer cases of bilateral lung infiltration and respiratory failure, and shorter viral clearance time and duration of symptoms (p &lt; 0.05). HA levels were significantly higher in patients with primary infection [128.0 (90.5, 185.0) vs. 94.5 (62.0, 167.3), p = 0.008], those with prolonged viral clearance time [90.5 (61.5, 130.8) vs. 130.0 (95.0, 188.0), p &lt; 0.001], and deceased patients [105.5 (76.8, 164.5) vs. 188.0 (118.0, 208.0), p = 0.002]. Further analysis showed that HA was an independent predictor of death (AUC: 0.789), and the risk of death increased by 4.435 times (OR = 5.435, 95% CI = 1.205–24.510, p = 0.028) in patients with high HA levels. We found that patients with HA levels above 116 ng/mL had an increased risk of death. However, the incidence of long COVID was similar in the different HA level groups (p &gt; 0.05).ConclusionSerum HA may serve as a novel biomarker for predicting COVID-19 mortality in patients with SARS-CoV-2 reinfection and first infection. However, HA levels may not be associated with long COVID.
ACTL6A: unraveling its prognostic impact and paving the way for targeted therapeutics in carcinogenesis
Authors: Eid Refaat A. , Mamdouh Farag , Abdulsahib Waleed K. , Alshaya Dalal Sulaiman , Al-Salmi Fawziah A. , Ali Alghamdi Maha , Jafri Ibrahim , Fayad Eman , Alsharif Ghadi , Zaki Mohamed Samir A. , Alshehri Mohammed A. , Noreldin Ahmed E. , Alaa Eldeen Muhammad 
Published: May 2024

Introduction: Increased Actin-like 6A (ACTL6A) expression is associated with various cancers, but its comprehensive investigation across different malignancies is lacking. We aimed to analyze ACTL6A as a potential oncogene and therapeutic target using bioinformatics tools.Methods: We comprehensively analyzed ACTL6A expression profiles across human malignancies, focusing on correlations with tumor grade, stage, metastasis, and patient survival. Genetic alterations were examined, and the epigenetic landscape of ACTL6A was assessed using rigorous methods. The impact of ACTL6A on immune cell infiltration in the tumor microenvironment was evaluated, along with molecular docking studies and machine learning models.Results: Our analysis revealed elevated ACTL6A expression in various tumors, correlating with poor prognostic indicators such as tumor grade, stage, metastasis, and patient survival. Genetic mutations and epigenetic modifications were identified, along with associations with immune cell infiltration and key cellular pathways. Machine learning models demonstrated ACTL6A's potential for cancer detection.Discussion: ACTL6A emerges as a promising diagnostic and therapeutic target in cancer, with implications for prognosis and therapy. Our study provides comprehensive insights into its carcinogenic actions, highlighting its potential as both a prognostic indicator and a target for anti-cancer therapy. This integrative approach enhances our understanding of ACTL6A's role in cancer pathogenesis and treatment.
Enhanced organic photovoltaic-based retinal prosthesis using a cathode-modified structure with plasmonic silver nanoparticles: a computational study
Authors: Rahmani Ali , Eom Kyungsik 
Published: May 2024

IntroductionOrganic interfaces have recently emerged as a breakthrough trend in biomedical applications, demonstrating exceptional performance in stimulating retinal neuronal cells owing to their high flexibility and compatibility with tissues. However, the primary challenge associated with organic photovoltaics is their low efficiency compared to that of their inorganic counterparts. Among different approaches, embedding plasmonic metal nanoparticles (NPs) in active or buffer layers can efficiently improve photovoltaic cell performance.MethodsA cathode decorated with silver nanoparticles is introduced to increase the absorption Phenomenon and improve the interface performance as a computational study. In addition to embedding spherical silver nanoparticles in the active layer (A-AgNPs), a monolayer array of spherical AgNPs in the cathode electrode (K-AgNPs) is incorporated. In this configuration, the large K-AgNPs play dual roles: acting as cathode electrode and serving as plasmonic centers to increase light trapping and absorption. The bulk heterojunction PCPDTBT:PCBM is chosen as the active layer due to its favorable electronic properties.ResultsOur computational analysis demonstrates a notable 10% enhancement in the photovoltaic cell current density for the developed structure with K-AgNPs in contrast to without them. Additionally, the simulation results reveal that the modeled device achieves a two-fold efficiency of the bare photovoltaic cell (without A-AgNPs and K-AgNPs), which is particularly evident at a low intensity of 0.26 mW/mm2.DiscussionThis study aims to propose an efficient epiretinal prosthesis structure using a different strategy for plasmonic effects rather than conventional methods, such as incorporating NPs into the active or buffer layer. This structure can prevent the harmful side effects of using large metal NPs (r &gt; 10 nm) in the active layer during exciton quenching, charge trapping, and recombination, which deteriorate the power conversion efficiency (PCE).
Investigation of the differential susceptibility of extraocular muscles in patients diagnosed with ocular myasthenia gravis based on the computerized diplopia test and the Ocular Motor Nerve Palsy Scale
Authors: Fan Yi-fei , Tu Sai-jun , Liu Yani , Li Xue-mei , Liu Tie-juan , Zhou Ling-yun 
Published: May 2024

IntroductionThe pattern of extraocular muscle involvement in ocular myasthenia gravis varies across different reports, diverging from our own observations. Thus, we employed two novel tools to discern this pattern.MethodsA retrospective analysis was conducted to collect and organize clinical data from 43 patients diagnosed with ocular myasthenia gravis. Each patient underwent both the computerized diplopia test and the Ocular Motor Nerve Palsy Scale assessment to evaluate the involvement of extraocular muscles.ResultsAmong the patients, there were 30 male and 13 female individuals, with a total of 113 affected extraocular muscles identified. Among all the affected extraocular muscles, the involvement of the levator palpebrae superioris muscle accounted for 35.40%, medial rectus muscle 7.7%, lateral rectus muscle 16.81%, superior rectus muscle 13.27%, inferior rectus muscle 12.39%, superior oblique muscle 1.77%, and inferior oblique muscle 2.65% of the total affected extraocular muscles. The positivity rates of the Neostigmine test were 89.19%, AChR antibody detection was 59.38%, and repetitive nerve stimulation was 34.38%. The AChR antibody positive rate among patients with only diplopia was 100%; among those with only ptosis, it was 80%; and among those with both diplopia and ptosis, it was 86.67%.ConclusionThe involvement of the extraocular muscles is not uniform. The levator palpebrae superioris exhibits the highest incidence rate, followed by the four rectus muscles and two oblique muscles. The inferior oblique involvement typically occurs when four or more EOMs are affected. Moreover, the levator palpebrae superioris and medial rectus show a higher tendency for bilateral involvement compared with other extraocular muscles.
Improving rehabilitation motivation and motor learning ability of stroke patients using different reward strategies: study protocol for a single-center, randomized controlled trial
Authors: Zhao Jingwang , Guo Jiangling , Chen Yeping , Li Wenxi , Zhou Ping , Zhu Guangyue , Han Peipei , Xu Dongsheng 
Published: May 2024

BackgroundStroke survivors often face challenges in motor learning and motivation during rehabilitation, which can impede their recovery progress. Traditional rehabilitation methods vary in effectiveness, prompting the exploration of novel approaches such as reward strategies. Previous research indicates that rewards can enhance rehabilitation motivation and facilitate motor learning. However, most reward paradigms have utilized fixed reward amounts, which also have limitations. Exploring alternative, more effective reward strategies, such as probabilistic rewards, is warranted to optimize stroke patient rehabilitation.MethodsA total of 81 stroke patients will be recruited and randomly assigned to control, fixed reward, or probabilistic reward groups at a ratio of 1:1:1 using a randomized number table method. Participants will undergo 10 days of daily hand motor function rehabilitation training, with sessions lasting 20 min each. The training will involve pegboard tests and box and block tests. Control group participants will receive standard training, while fixed reward group members will receive monetary incentives for completing tests, and probabilistic reward group members will have the chance to win monetary rewards through a lottery box. Rehabilitation motivation and motor performance and functional near-infrared spectroscopy brain imaging will be conducted at designated time points. The primary outcome measure is the stroke rehabilitation motivation scale, and the second outcome measures include motor performance, simple test for evaluating hand function, motivation and pleasure scale self-report, and Pittsburgh rehabilitation participation scale.DiscussionReward-based training enhance rehabilitation participation and adherence, it also improve motor learning speed and memory retention of stroke patients. The fixed reward applied in the past studies could diminish the sensitivity of stroke patients to rewards, while probabilistic reward may provide unpredictable or variable incentives or reinforcements for motor rehabilitation. This study will compare the efficacy of different reward strategies in enhancing motor learning ability and rehabilitation motivation among stroke patients. By conducting a randomized controlled trial, the study seeks to provide valuable insights into optimizing stroke rehabilitation protocols and improving patient outcomes.Clinical Trial Registration:https://www.chictr.org.cn/, ChiCTR2400082419.