bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implications of Representing Snowpack Stratigraphy for the Assimilation of Passive Microwave Satellite Observations
Authors: Andreadis Konstantinos M. , Lettenmaier Dennis P. 
Published: May 2012

Abstract
Under certain conditions, passive microwave satellite observations can be used to estimate snow water equivalent (SWE) across large areas, either through direct retrieval or data assimilation. However, the layered character of snowpacks increases the complexities of estimation algorithms. A multilayer model of snowpack stratigraphy that can serve as the forward model of a snow data assimilation system is described and evaluated. The model’s ability to replicate large-scale snowpack layer features is evaluated using observations from the Cold Land Processes Experiment (Colorado, 2002 and 2003) and a 2002 Nome–Barrow snowpit transect [Snow Science Traverse—Alaska Region (SnowSTAR2002)]. The multilayer model linked with a radiative transfer scheme improved the estimation of brightness temperatures both in terms of absolute values and frequency/polarization differences (error reductions ranging from 47% to 72%) relative to a one-layer model with similar, but depth-averaged, physics at the Colorado sites. The two models were also employed along the SnowSTAR2002 transect of snowpit measurements. The general unavailability of meteorological forcings along the transect made the use of coarse-scale reanalysis data necessary to simulate snow properties and microwave radiances. Errors in the precipitation forcings led to overestimation of SWE, and the simulated brightness temperatures from the two models showed large differences, due mostly to the inability of the single-layer model to simulate the observed larger grain sizes. These differences had implications for the estimation of snow depth; assimilation of Special Sensor Microwave Imager (SSM/I) observations into the multilayer model resulted in improved snow depth estimates (RMSEs of 18.1 cm versus 34.1 cm without assimilation), while the single-layer assimilation slightly decreased the estimation skill (RMSEs of 34.1 versus 33.6 cm).
Two-Component Horizontal Aerosol Motion Vectors in the Atmospheric Surface Layer from a Cross-Correlation Algorithm Applied to Scanning Elastic Backscatter Lidar Data*
Authors: Mayor Shane D. , Lowe Jennifer P. , Mauzey Christopher F. 
Published: May 2012

Abstract
Two-component horizontal motion vectors of aerosol features were calculated by applying a cross-correlation algorithm to square image blocks extracted from consecutive pairs of elastic backscatter lidar scans. The resulting vector components were compared with corresponding horizontal wind components from tower-mounted sonic anemometers located at the center of the image blocks. In the analysis 180 245 pairs of vectors derived from 75 days of field data collected between 19 March and 11 June 2007 were used. Examples of time series comparisons from 4-h periods during light, strong, and changing wind conditions are presented. Mean signal-to-noise ratios (SNRs) of the block backscatter data, maxima of the cross-correlation functions (CCFs), observed wind speed, and turbulent kinetic energy (TKE) were also calculated for each velocity component comparison. The correlation between the lidar-derived motion components and sonic anemometer wind components tends to be highest during light wind conditions with low TKE. An empirical relationship is presented that enables the elimination of vectors that are likely to be significantly different than the anemometer measurement. When applied to the entire set of scans available, this quality control (QC) method increases the correlation between the two forms of measurements. Finally, the cross-correlation algorithm and QC method are applied to a mesh of locations over pairs of scans. Two examples of two-dimensional and two-component vector flow fields are shown. In one case, the flow field reveals a rotational circulation associated with a vortex and, in the other case, convergence and transport near the leading edge of a density current front.
Continuous Parenteral and Enteral Nutrition Induces Metabolic Dysfunction in Neonatal Pigs
Authors: Stoll Barbara , Puiman Patrycja Jolanta , Cui Liwei , Chang Xiaoyan , Benight Nancy Marie , Bauchart‐Thevret Caroline , Hartmann Bolette , Holst Jens Juul , Burrin Douglas Guy 
Published: May 2012

Background:We previously showed that parenteral nutrition (PN) compared with formula feeding results in hepatic insulin resistance and steatosis in neonatal pigs. The current aim was to test whether the route of feeding (intravenous [IV] vs enteral) rather than other feeding modalities (diet, pattern) had contributed to the outcome.Methods:Neonatal pigs were fed enterally or parenterally for 14 days with 1 of 4 feeding modalities as follows: (1) enteral polymeric formula intermittently (FORM), (2) enteral elemental diet (ED) intermittently (IEN), (3) enteral ED continuously (CEN), and (4) parenteral ED continuously (PN). Subgroups of pigs underwent IV glucose tolerance tests (IVGTT) and hyperinsulinemic‐euglycemic clamps (CLAMP). Following CLAMP, pigs were euthanized and tissues collected for further analysis.Results:Insulin secretion during IVGTT was significantly higher and glucose infusion rates during CLAMP were lower in CEN and PN than in FORM and IEN. Endogenous glucose production rate was suppressed to zero in all groups during CLAMP. In the fed state, plasma glucose‐dependent insulinotropic polypeptide (GIP), glucagon‐like peptide (GLP)–1, and GLP‐2 were different between feeding modalities. Insulin receptor phosphorylation in liver and muscle was decreased in IEN, CEN, and PN compared with FORM. Liver weight was highest in PN. Steatosis and myeloperoxidase (MPO) activity tended to be highest in PN and CEN. Enterally fed groups had higher plasma GLP‐2 and jejunum weight compared with PN.Conclusions:PN and enteral nutrition (EN) when given continuously as an elemental diet reduces insulin sensitivity and the secretion of key gut incretins. The intermittent vs continuous pattern of EN produced the optimal effect on metabolic function.
Renal Histopathology of a Baboon Model with Type 2 Diabetes
Authors: Rincon-Choles Hernan , Abboud Hanna E. , Lee Shuko , Shade Robert E. , Rice Karen S. , Carey K. Dee , Comuzzie Anthony G. , Barnes Jeffrey L. 
Published: May 2012

Naturally occurring type 2 diabetes has been found in a colony of baboons. Ongoing characterization of the baboon colony maintained at the Southwest National Primate Research Center has revealed a significant range of glucose sensitivity with some animals clearly diabetic. Seven baboons, four with diabetes and three without diabetes, underwent histopathological investigation. Three diabetic animals were diagnosed using fasting blood glucose, hemoglobin A1C, and intravenous glucose tolerance test, and a fourth one was known to have hyperglycemia. One control baboon and three baboons with diabetes had microalbuminuria. On kidney biopsy, diabetic baboons had thickening of the glomerular basement membrane and mesangial matrix expansion compared to controls. Immunohistochemistry showed the diabetic animals had increased mesangial expression of cellular fibronectin ED-A. Two diabetic animals with microalbuminuria had evidence of mesangiolysis with the formation of an early nodule. One diabetic animal had a Kimmestiel–Wilson nodule. We conclude that the baboon represents a useful primate model of diabetes and nephropathy that resembles the nephropathy associated with type 2 diabetes in humans.
A Multilevel Evaluation of a Comprehensive Child Abuse Prevention Program
Authors: Lawson Michael A. , Alameda-Lawson Tania , Byrnes Edward C. 
Published: May 2012

Objectives: The purpose of this study is to examine the extent to which participation in a county-wide prevention program leads to improvements in protective factors associated with child abuse prevention (CAP) and whether improvements in measured protective factors relate to decreased odds of child abuse. Method: Using multilevel growth modeling, our analyses focus on an economically poor, culturally diverse sample of 1,184 mothers who maintained their involvement in the program for at least 6 months. Results: Our results support a limited association between program participation and improvements in maternal protective factors. Nevertheless, pursuant to the working theory of many CAP programs, improvements in maternal social support and mental health, when evident, were significantly associated with reduced odds of child abuse. Conclusion: More robustly specified interventions and supports are needed to enhance outcomes for the majority of families targeted by the program, including those who present the greatest vulnerability for child abuse.
The Item Veto's Sting
Authors: Brown Adam R. 
Published: May 2012

AbstractDespite lofty expectations from the item veto's proponents (and fears from its opponents), formal models have suggested that the item veto is unlikely to have much effect beyond what a full veto could render. However, I show that different findings obtain when item vetoes are appreciated more fully as a dimensionality-reducing institution. I begin by developing a package veto model in a generalized multidimensional space. I then show how introducing the item veto changes the outcome by forcing veto bargaining into what is essentially a unidimensional space. As a result, executives with an item veto or other dimensionality-reducing institution (such as a single-subject rule) can be far more powerful in legislative bargaining than executives who lack these tools, other things being equal. I use simulations to demonstrate the model's main implications.
NF-κB p50 subunit knockout impairs late LTP and alters long term memory in the mouse hippocampus
Authors: Oikawa Kensuke , Odero Gary L , Platt Eric , Neuendorff Melanie , Hatherell Avril , Bernstein Michael J , Albensi Benedict C 
Published: May 2012

Abstract

Background
Nuclear factor kappa B (NF-κB) is a transcription factor typically expressed with two specific subunits (p50, p65). Investigators have reported that NF-κB is activated during the induction of in vitro long term potentiation (LTP), a paradigm of synaptic plasticity and correlate of memory, suggesting that NF-κB may be necessary for some aspects of memory encoding. Furthermore, NF-κB has been implicated as a potential requirement in behavioral tests of memory. Unfortunately, very little work has been done to explore the effects of deleting specific NF-κB subunits on memory. Studies have shown that NF-κB p50 subunit deletion (p50−/−) leads to memory deficits, however some recent studies suggest the contrary where p50−/− mice show enhanced memory in the Morris water maze (MWM). To more critically explore the role of the NF-κB p50 subunit in synaptic plasticity and memory, we assessed long term spatial memory in vivo using the MWM, and synaptic plasticity in vitro utilizing high frequency stimuli capable of eliciting LTP in slices from the hippocampus of NF-κB p50−/− versus their controls (p50+/+).

Results
We found that the lack of the NF-κB p50 subunit led to significant decreases in late LTP and in selective but significant alterations in MWM tests (i.e., some improvements during acquisition, but deficits during retention).

Conclusions
These results support the hypothesis that the NF-κ p50 subunit is required in long term spatial memory in the hippocampus.
Cross-sectional study of availability and pharmaceutical quality of antibiotics requested with or without prescription (Over The Counter) in Surabaya, Indonesia
Authors: Hadi Usman , van den Broek Peterhans , Kolopaking Erni P , Zairina Nun , Gardjito Widjoseno , Gyssens Inge C ,   the Study Group 'Antimicrobial Resistance in Indonesia: Prevalence and Prevention' (AMRIN)
Published: May 2012

Abstract

Background
Antimicrobial resistance is an increasing problem in developing countries and antibiotic use is widespread. Our previous surveys in Java, Indonesia, revealed that most antibiotic use was probably unnecessary or ineffective. The aim of this study was to explore a potential connection between resistance and substandard antibiotics sold in the area.

Methods
A cross-sectional field study using the simulated client method was conducted in Surabaya. Five first-line antibiotics were requested with or without prescription (OTC). A certified laboratory analysed the drug content using validated methods. Possible determinants of substandard quality were explored.

Results
In total, 104 samples from 75 pharmacies, ten drug stores and 39 roadside stalls (kiosks) were obtained. Pharmacy employees filled all OTC requests. Three quarters of kiosks sold antibiotics. Antibiotics were dispensed as single blister strips or repackaged (16%) without label. Ninety five percent of samples carried the label of 14 Indonesian manufacturers. The pharmaceutical quality did not meet BP standards for 18% of samples. Deviations (less active ingredient) were small. There was no association between low content and type of outlet, sold with or without prescription, registration type, price or packaging. Median retail prices of products carrying the same label varied up to 20 fold.

Conclusions
Antibiotics were available OTC in all visited pharmacies and sold in the streets of an Indonesian city. Most samples contained an active ingredient. We urge to increase enforcement of existing regulations, including legislation that categorizes antibiotics as prescription-only drugs for all types of medicine outlets, to limit further selection of antimicrobial resistance.
Extraperitoneal urine leak after renal transplantation: the role of radionuclide imaging and the value of accompanying SPECT/CT - a case report
Authors: Son Hongju , Heiba Sherif , Kostakoglu Lale , Machac Josef 
Published: May 2012

Abstract

Background
The differentiation of the nature of a fluid collection as a complication of kidney transplantation is important for management and treatment planning. Early and delayed radionuclide renography can play an important role in the evaluation of a urine leak. However, it is sometimes limited in the evaluation of the exact location and extent of a urine leak.

Case Presentation
A 71-year-old male who had sudden anuria, scrotal swelling and elevated creatinine level after cadaveric renal transplantation performed Tc-99 m MAG3 renography to evaluate the renal function, followed by an ultrasound which was unremarkable. An extensive urine leak was evident on the planar images. However, an exact location of the urine leak was unknown. Accompanying SPECT/CT images confirmed a urine leak extending from the lower aspect of the transplant kidney to the floor of the pelvic cavity, presacral region and the scrotum via right inguinal canal as well as to the right abdominal wall.

Conclusions
Renal scintigraphy is very useful to detect a urine leak after renal transplantation. However, planar imaging is sometimes limited in evaluating the anatomical location and extent of a urine leak accurately. In that case accompanying SPECT/CT images are very helpful and valuable to evaluate the anatomical relationships exactly.
Clinical outcomes and immune benefits of anti-epileptic drug therapy in HIV/AIDS
Authors: Lee Kathy , Vivithanaporn Pornpun , Siemieniuk Reed A , Krentz Hartmut B , Maingat Ferdinand , Gill M John , Power Christopher 
Published: May 2012

Abstract

Background
Anti-epileptic drugs (AEDs) are frequently prescribed to persons with HIV/AIDS receiving combination antiretroviral therapy (cART) although the extent of AED use and their interactions with cART are uncertain. Herein, AED usage, associated toxicities and immune consequences were investigated.

Methods
HIV replication was analysed in proliferating human T cells during AED exposure. Patients receiving AEDs in a geographically-based HIV care program were assessed using clinical and laboratory variables in addition to assessing AED indication, type, and cumulative exposures.

Results
Valproate suppressed proliferation in vitro of both HIV-infected and uninfected T cells (p < 0.05) but AED exposures did not affect HIV production in vitro. Among 1345 HIV/AIDS persons in active care between 2001 and 2007, 169 individuals were exposed to AEDs for the following indications: peripheral neuropathy/neuropathic pain (60%), seizure/epilepsy (24%), mood disorder (13%) and movement disorder (2%). The most frequently prescribed AEDs were calcium channel blockers (gabapentin/pregabalin), followed by sodium channel blockers (phenytoin, carbamazepine, lamotrigine) and valproate. In a nested cohort of 55 AED-treated patients receiving cART and aviremic, chronic exposure to sodium and calcium channel blocking AEDs was associated with increased CD4+ T cell levels (p < 0.05) with no change in CD8+ T cell levels over 12 months from the beginning of AED therapy.

Conclusions
AEDs were prescribed for multiple indications without major adverse effects in this population but immune status in patients receiving sodium or calcium channel blocking drugs was improved.
Contractile properties and movement behaviour in neonatal rats with axotomy, treated with the NMDA antagonist DAP5
Authors: Petsanis Konstantinos , Chatzisotiriou Athanasios , Kapoukranidou Dorothea , Simeonidou Constantina , Kouvelas Dimitrios , Albani Maria 
Published: May 2012

Abstract

Background
It is well known that axotomy in the neonatal period causes massive loss of motoneurons, which is reflected in the reduction of the number of motor units and the alteration in muscle properties. This type of neuronal death is attributed to the excessive activation of the ionotropic glutamate receptors (glutamate excitotoxicity). In the present study we investigated the effect of the NMDA antagonist DAP5 [D-2-amino-5-phosphonopentanoic acid] in systemic administration, on muscle properties and on behavioural aspects following peripheral nerve injury.

Methods
Wistar rats were subjected to sciatic nerve crush on the second postnatal day. Four experimental groups were included in this study: a) controls (injection of 0.9% NaCl solution) b) crush c) DAP5 treated and d) crush and DAP5 treated. Animals were examined with isometric tension recordings of the fast extensor digitorum longus and the slow soleus muscles, as well as with locomotor tests at four time points, at P14, P21, P28 and adulthood (2 months).

Results
1. Administration of DAP5 alone provoked no apparent adverse effects. 2. In all age groups, animals with crush developed significantly less tension than the controls in both muscles and had a worse performance in locomotor tests (p<0.01). Crush animals injected with DAP5 were definitely improved as their tension recordings and their locomotor behaviour were significantly improved compared to axotomized ones (p<0.01). 3. The time course of soleus contraction was not altered by axotomy and the muscle remained slow-contracting in all developmental stages in all experimental groups. EDL, on the other hand, became slower after the crush (p<0.05). DAP5 administration restored the contraction velocity, even up to the level of control animals 4. Following crush, EDL becomes fatigue resistant after P21 (p<0.01). Soleus, on the other hand, becomes less fatigue resistant. DAP5 restored the profile in both muscles.

Conclusions
Our results confirm that contractile properties and locomotor behaviour of animals are severely affected by axotomy, with a differential impact on fast contracting muscles. Administration of DAP5 reverses these devastating effects, without any observable side-effects. This agent could possibly show a therapeutic potential in other models of excitotoxic injury as well.
Angiotensin II directly regulates intestinal epithelial NHE3 in Caco2BBE cells
Authors: Musch Mark W , Li Yan Chun , Chang Eugene B 
Published: May 2012

Abstract

Background
Angiotensin II (AII) effects on intestinal Na+ transport may be multifactorial. To determine if AII might have a direct effect on intestinal epithelial Na+ transport, we investigated its actions on Na+ transport in human intestinal epithelial Caco2BBE cells.

Results
AII increased apical (brush border) sodium-hydrogen exchanger (NHE)-3, but not NHE2, activity within one hour. Similarly, only apical membrane NHE3 abundance increased at 1–2 hours without any change in total NHE3 protein abundance. From 4–48 hours, AII stimulated progressively larger increases in apical NHE3 activity and surface abundance, which was associated with increases in NHE3 protein expression. At 4–24 hours, NHE3 mRNA increases over baseline expression, suggesting increased gene transcription. This was supported by AII induced increases in rat NHE3 gene promoter-reporter activity. AII induction of NHE3 was blocked by the AII type I receptor antagonist losartan. Acute changes in AII-induced increases in NHE3 exocytosis were blocked by a phospholipase C inhibitor, an arachidonic acid cytochrome P450 epoxygenase inhibitor, as well as phosphatidylinositol 3 kinase (PI3K) inhibitors and Akt inhibitor, partially blocked by a metalloproteinase inhibitor and an EGF (epidermal growth factor) receptor kinase inhibitor, but not affected by an inhibitor of MEK-1 (MAPKK-1, mitogen activated protein kinase kinase-1).

Conclusion
We conclude that angiotensin II has a direct role in regulating intestinal fluid and electrolyte absorption which may contribute to its overall effects in regulation systemic volume and blood pressure. AII activates several key signaling pathways that induce acute and chronic changes in NHE3 membrane trafficking and gene transcription.
Malocclusion, psycho-social impacts and treatment need: A cross-sectional study of Tanzanian primary school-children
Authors: Mtaya Matilda , Astrom Anne N , Brudvik Pongsri 
Published: May 2012

Abstract

Background
studies on the relationship between children's malocclusion and its psycho-social impacts are so far largely unexplored in low-income countries. This study aimed to assess the prevalence of malocclusion, reported dental problems and dissatisfaction with dental appearance among primary school children in Tanzania. The relationship of dissatisfaction with socio-demographic characteristics, clinically defined malocclusion and psychosocial impacts of dental anomalies was investigated. Orthodontic treatment need was estimated using an integrated socio-dental approach.

Method
One thousand six hundred and one children (mean age 13 yr) attending primary schools in the districts of Kinondoni and Temeke completed face to face interviews and a full mouth clinical examination. The survey instrument was designed to measure a Kiswahili translated and culturally adapted Child Oral Impact on Daily Performance (Child-OIDP) frequency score, reported dental problems, dissatisfaction with dental appearance/function and socio-demographic characteristics.

Results
The prevalence of malocclusion varied from 0.9% (deep bite) to 22.5% (midline shift) with a total of 63.8% having at least one type of anomaly. Moderate proportions of children admitted dental problems; ranging from 7% (space position) to 20% (pain). The odds ratio of having problems with teeth position, spaces, pain and swallowing if having any malocclusion were, respectively 6.7, 3.9, 1.4 and 6.8. A total of 23.3% children were dissatisfied with dental appearance/function. Children dissatisfied with their dental appearance were less likely to be Temeke residents (OR = 0.5) and having parents of higher education (OR = 0.6) and more likely to reporting problem with teeth position (OR = 4.3) and having oral impacts (OR = 2.7). The socio-dental treatment need of 12% was five times lower than the normative need assessment of 63.8%.

Conclusion
Compared to the high prevalence of malocclusion, psycho social impacts and dissatisfaction with appearance/function was not frequent among Tanzanian schoolchildren. Subjects with malocclusion reported problems most frequently and malocclusion together with other psycho-social impact scores determined children's satisfaction with teeth appearance- and function.