bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two Uterine Arterial Management Methods in Laparoscopic Hysterectomy*
Authors: Song Joon , Cho Sung Jin , Park Chang Seo , Kim Sun Haeng , Ku Pyong Sahm , Lee Myung Ah 
Published: May 2010

AbstractObjective: The purpose of this study was to evaluate whether laparoscopic separation with coagulation of the uterine arteries and uterosacral ligaments can be used in an attempt to improve the operative procedure when hysterectomy is carried out by laparoscopic and vaginal method.Method: A prospective study was carried out in 70 women who underwent laparoscopic hysterectomy excluding total laparoscopic hysterectomy. Laparoscopic uterine arterial separation with coagulation (include laparoscopic reperitonization) was performed after laparoscopic detachment of the bladder and resection of the broad ligament (or adnexa) in 39 cases (Group 1). Uterine artery was coagulated by bipolar electrocoagulator and separated from the uterine side wall by scissors. Endoloop tie was applied to the arterial pedicle, if bleeding occurred. Uterine arterial management was performed through the vaginal route (include vaginal reperitonization) after laparoscopic procedure which was finished at the lower part of broad ligament with bladder detachment in 31 cases (Group 2).Results:The average duration of operation was 84.0 min and 101.8 min in Groups 1 and 2, respectively (p < 0.05). The average amount of bleeding was 154.8 ml and 298.4 ml in Groups 1 and 2, respectively (p < 0.05). Hemoglobin decreased in average by 0.9 g/100 ml and 1.6 g/100 ml in Groups 1 and 2, respectively (p < 0.05).Conclusion:These results demonstrate that laparoscopic management of uterine arterial pedicles after bladder detachment could reduce the duration of operation time and amount of bleeding in laparoscopic hysterectomy.
Non‐Hodgkin's Lymphoma Presenting as a Primary Lesion in Uterine Cervix:Case Report
Authors: Chandy Lata , Kumar Lalit , Dawar Ramesh 
Published: May 2010

AbstractNon‐Hodgkin's lymphoma (NHL) arising from extra nodal tissue and staying localized to that region is rare. Rarer still is primary NHL of the uterine cervix. We describe a patient with primary extra nodal NHL of the uterine cervix and vagina who was treated successfully with chemotherapy and radiotherapy. She is free of disease 17 months after treatment. Data of 52 patients collected from the literature (Medline, National Library of Medicine, Bethesda, MD) is reviewed.
Triplet Pregnancy Complicated by a Gradual Decline in Antithrombin‐IH Activity and HELLP Syndrome: A Case Report
Authors: Izumi Akio , Minakami Hisanori , Matsubara Shigeki , Sato Ikuo 
Published: May 2010

AbstractWe prospectively evaluated the antenatal changes in antithrombin‐III (AT‐III) activity and liver enzymes in a woman with a triplet pregnancy. A gradual decline in AT‐III activity occurred in the absence of clinical signs of preeclampsia and preceded the onset of the typical HELLP syndrome in this patient. Monitoring of AT‐III activity might help to avoid the development of severe HELLP syndrome.
Differences of IgG and IgM Antibodies to Phospholipids and APTT among Non‐Pregnant and Pregnant Women
Authors: Shimano Satoshi , Kurosu Takaji , Hayama Kenji , Aoki Sigeo , Ishida Yuiti , Komae Yoshio 
Published: May 2010

AbstractObjective: The objective of our study was to assess the difference in IgG and IgM antibodies to cardiolipin(CL), phosphatidylserine(PS), and APTT among non‐pregnant and pregnant women.Methods: IgG and IgM antibodies to CL and PS among 102 healthy non‐pregnant women and 154 healthy pregnant women were measured by an ELISA. The activated partial thromboplastin time(APTT) was measured in 67 healthy non‐pregnant women, in 67 healthy women at 10—14 weeks of gestation, and in 67 healthy women at 30–32 weeks of gestation. We compared the titer of + 2SD in each group.Results: The titers + 2SD of IgG antibodies to CL and PS in pregnant women were lower than in non‐pregnant women (p < 0.05), whereas the values of the IgM antibody to CL and PS were the same in pregnant and non‐pregnant women. The APTT in pregnant women was significantly shorter than in non‐pregnant women (p = 0.0001).Conclusion: Standard criteria for the positivity of the IgG antibody to CL and PS and the prolongation of APTT in pregnancy should employ the values of normal pregnant women rather than those of non‐pregnant women.
Detection of Numerical Chromosome Abnormalities in Human Spermatozoa by Three‐Color Fluorescence in situ Hybridization
Authors: Li Ping , Hoshiai Hiroshi 
Published: May 2010

AbstractThree‐color fluorescence in situ hybridization (FISH) was used to detect numerical X, Y, and 17 chromosomal aberrations in human sperm nuclei. Digoxigenin‐labeled alpha satellite chromosome X‐specific probe DXZ1, biotin‐labeled classical satellite chromosome Y‐specific probe DYZ1, and biotin plus digoxigenin‐labeled alpha satellite chromosome 17‐specific probe D17Z1 were simultaneously hybridized to sperm preparations from donors with normal semen (group A) and abnormal semen (group B) characteristics. The proportions of haploid X, Y, 17 and disomy, diploidy of them before and after swim‐up were determined. At least 3,000 sperm were analyzed for each sample. Overall, up to 98% of sperm were labeled with the probes, and all statistical analyses were performed using χ2 tests. A significant difference was observed between group A and group B in frequency of sex chromosome disomy (p < 0.05). In group B, there were significant differences in frequencies of sex chromosomes disomy (p < 0.05) and diploidy (p < 0.01) before to after swim‐up. There was no significant difference in frequency of disomy 17 between the 2 groups. In group A and B, the ratios of X‐ to Y‐bearing sperm were 1:1 (neat semen), but in both groups there was a significant increase in Y‐bearing sperm after swim‐up. The results of this study demonstrated that abnormal semen has sex chromosome disomy more frequently than does normal semen and that portion of sex chromosome di‐somic and diploid sperm is removed by swim‐up, especially for abnormal semen. These findings suggest that we should be careful in using abnormal semen for IVF, especially for ICSI, and should perform swim‐up if possible.
Single Agent Versus Combination Chemotherapy in Recurrent Cervical Cancer
Authors: Kumar Lalit , Pokharel Y. H. , Kumar S. , Singh Rajveer , Rath G. K. , Kochupillai V. 
Published: May 2010

AbstractObjective:Cisplatin and ifosfamide are two most active agents in patients with recurrent and metastatic cervical cancer. Combination of bleomycin, ifosfamide and cisplatinum (BIP) was compared with cisplatinum alone.Patients and Methods: One hundred and six patients with recurrent/persistent and metastatic cervical cancer received either a combination of bleomycin, ifosfamide and cisplatinum, (Group A, n = 50) or cisplatinum alone (Group B, n = 56) every 3 weeks for up to 6 courses. Ninety‐seven patients were evaluable and were analysed for response and survival.Results:Patients receiving BIP (Group A) had a higher response rate (complete and partial responses), 52.2% vs 29.4%, p < 0.01 with overall median survival, 8 months (1 to 92+ months) vs 6 months (1 to 40+ months), p = 0.18. Chemotherapy responders had a significantly higher survival in both groups compared to the non‐responders (Group A: 17 vs 6 months, p< 0.001, Group B: 20.5 months vs 5 months, p < 0.001). Patients in good performance status (ECOG, 0—2) had a significantly higher response rate to chemotherapy (Group A: 70.3% vs 26.3%, p < 0.01, Group B: 38.2% vs 11.7%, p < 0.05). In Group A, patients with extrapelvic disease responded better compared to pelvic disease (83.3% vs 34.5%, p < 0.01).Chemotherapy side effects were mainly nausea/vomiting, alopecia, myelosuppres‐sion, reversible encephalopathy (in Group A), and impaired renal functions. Chemotherapy toxicity was higher for patients receiving BIP, 2 patients died of BIP toxic‐ity. Currently, in ‘Group A’ 8 patients are alive, 7 disease‐free and one with disease at a median interval of 51 months after chemotherapy treatment. While in Group B, 3 patients are alive, 2 disease‐free and one with disease.Conclusions:Bleomycin, ifosfamide and cisplatin improved the response rate in recurrent and metastatic cervical cancer compared with cisplatinum alone. However, the toxicity was moderate and survival was not significantly improved. These results need to be confirmed in a phase III, randomized study in larger number of patients.
The Necessity for a Progressing Dialog between Basic Science and Clinical Research in Obstetrics and Gynecology*
Authors: Graeff Henner 
Published: May 2010

AbstractScientific breakthroughs and basic research are frequently published in prestigious journals and praised for their impact. However, progress in clinical medicine is tedious and slow. There is still a distinct and even widening gap between basic science and clinical application. The dialog between basic science and clinical research has therefore to be intensified and a new culture of cooperation between basic and physician‐scientists will become necessary to accelerate the transfer of new drugs into clinical practice.
Psychological and Obstetrical Responses of Mothers Following Antenatal Fetal Sex Identification
Authors: Kamel Hassan S. , Ahmed Hamdy N. , Eissa Mohammed A. , Abol‐Oyoun Al‐Sayed M. 
Published: May 2010

AbstractThis work was designed to study the impact of prenatal knowledge of fetal sex both on the psychological and obstetrical aspects of the expectant mothers during pregnancy and labour. One hundred pregnant women attending the outpatient antenatal clinic of Assiut University Hospital were recruited. All were in the third trimester, parous, with normal pregnancy and having no past or present psychiatric disorders. The desired sex of the expected child was registered. Symptom checklist 90 (SCL‐90) was applied before, and 2 weeks after sonographic fetal sex determination. Women who desired male sex scored significantly higher depressive symptoms than those who desired female sex. Women who were proven sonographically to have the undesired fetal sex showed significantly higher scores of depression, somatization, anxiety, hostility and phobia scales of SCL‐90 than women whose desired fetal sex was confirmed. The second part of the study to evaluate the effect of knowing the fetal sex on the progress of labour was designed as a case control study including 57 women previously informed about their fetal sex and 40 women ignorant of their fetal sex as controls. Women delivering a baby with undesired sex showed more obstetric difficulties. In the first stage of labour, they had significant reduction in frequency of uterine contractions and rate of cervical dilatation. They also needed much more sedation, analgesia and oxytocin augmentation.
Pregnancy‐Associated Osteoporosis with Elevated Levels of Circulating Parathyroid Hormone‐Related Protein: A Report of Two Cases
Authors: Anai Takanobu , Tomiyasu Toshiko , Arima Kazuyo , Miyakawa Isao 
Published: May 2010

AbstractTwo lactating women who had complained of back pain developed spontaneous vertebral fractures with low bone mineral density (BMD) several months postpartum. The back pain and biochemical abnormalities presented as hypercalcemia and elevated plasma levels of the parathyroid hormone‐related protein (PTH‐rP) that returned to normal indices with increasing BMD after weaning. The increased circulating PTH‐rP might contribute to the pregnancy‐associated osteoporosis in women who probably are already osteopenic.
Primary Malignant Melanoma of the Uterine Cervix: A Case Report
Authors: Takehara Masaki , Ito Eiki , Saito Tsuyoshi , Nishioka Yoshihiro , Kudo Ryuichi 
Published: May 2010

AbstractWe report on a case of a malignant melanoma of the uterine cervix. Histological and immunohistological examinations of a postsurgical specimen revealed malignant melanoma. The junctional activities did not occur due to extensive superficial ulceration. Radical surgery was performed. The patient is doing well and free of symptoms at this time, 2 1/2 year later.
A Prospective Study on the Effects of Reformulated 2‐rod Norplant Implant on Haemostasis after Five Years of Use
Authors: Koh Stephen C. L. , Viegas O. A. C. , Ratnam S. S. 
Published: May 2010

AbstractObjective: To evaluate the long‐term effects of the new reformulated 2‐rod Norplantr̀ implant on haemostasis in a prospective group of subjects who have completed 5 years of use.Methods: Data from 11 women who have completed 5 years' use of the new reformulated 2‐rod subdermal implant from the original 16 women who were recruited and randomized to receive this new improved implant in a comparative study were analysed. Clinical assessment and serial blood sampling were done prior to insertion of implant and after 1, 3, 12, 18, 24, 36, 48 and 60 months of implant use. Each subject served as its own control and Analysis of Variance with Student‐Newman‐Kuels test was used for statistical analysis. The following parameters were determined: plasminogen activators (t‐PA, u‐PA), plasminogen activator inhibitor‐1 (PAI‐1), D‐dimer, β‐thromboglobulin (β‐TG), thrombin‐antithrombin (TAT)‐complex, fibrinogen, Factor VII, platelets, haematocrit and haemoglobin levels.Results: No significant change was observed for t‐PA levels in prolonged implant use. u‐PA antigen showed a significant decrease whilst D‐dimer were significantly elevated at only 24 months of implant use compared to pre‐implant level. PAI‐1 levels were not significantly changed but fibrinogen and FVII levels increased at 36 months and 42 months of use with enhanced platelet activation shown by β‐TG levels at 24 months. Platelet numbers were not affected by prolonged implant use. Haemoglobin concentration and haematocrit level showed significant fluctuations and then return to pre‐implant level by 54 and 60 months.Conclusion: Enhanced fibrinolysis with platelet activation at 24 months of implant use were seen during the 60 months of 2‐rod reformulated Norplantr̀ implant use. Hypercoagu‐lable state was not observed although fibrinogen and FVII levels remain above the pre‐implant levels as coagulation activation was not enhanced. The increased haemoglobin and haematocrit levels seen indicate enhanced bone marrow activity. There was no association between the use of reformulated 2‐rod Norplantr̀ implant over 60 months of use and prothrombotic state.
Choriocarcinoma Co‐Existent with an Intact Pregnancy: Case Report and Review of the Literature
Authors: Steigrad Stephen J. , Cheung Anthony P. , Osborn Robert A. 
Published: May 2010

AbstractA patient presenting with antepartum haemorrhage due to a vaginal metastasis of choriocarcinoma is reported. Following delivery she was successfully treated with chemotherapy and surgery. This report details this unusual presentation and reviews the literature on this rare condition.
Sonographically Guided Intralesional Antibiotic Injection for Treatment of a Recalcitrant Pelvic Abscess: A Case Report*
Authors: Ou Ming‐Cheh , Ng Heung‐Tat , Tzeng Chii‐Ruey 
Published: May 2010

AbstractA pelvic abscess occurred in an infertile woman with an endocervical gonococcal infection after hysterosalpingographical examination. The pelvic abscess was not cured despite rigorous antimicrobial chemotherapy until two intra‐abscess ceftriaxone injections were administered. This shows that antibiotics administered systemically may not reach therapeutic concentration in an abscess and an intra‐abscess antibiotic injection may help to cure it.
Efficacy of Selective Venous Sampling to Localize a Small Ovarian Androgen‐Producing Tumor
Authors: Inoue Yoshihito , Kamura Toshiharu , Okuma Akiko , Shigematsu Toshiyuki , Amada Satoshi , Ogata Rika , Koga Miho , Nozaki Masahiro , Nakano Hitoo 
Published: May 2010

AbstractTwo cases of androgen‐producing tumors, including a Sertoli‐Leydig cell tumor in a woman of reproductive age and a Leydig cell tumor in a postmenopausal woman, are reported herein. In both cases, only selective venous sampling was able to detect the presence of the androgen‐producing ovarian tumors.
Remission of Idiopathic Hypoparathyroidism during Lactation: A Case Report
Authors: Anai Takanobu , Tomiyasu Toshiko , Takai Noriyuki , Miyakawa Isao 
Published: May 2010

AbstractA 35‐year‐old woman with idiopathic hypoparathyroidism achieved a spontaneous remission during lactation even though 1‐α‐hydroxyvitamin D3 therapy was discontinued after delivery. Urinary excretion of cyclic adenosine 3′,5′‐monophosphate and phosphate was significantly increased during lactation, probably in response to the increased levels of circulating parathyroid hormone‐related protein derived from the breast tissue.
A Case of Huge Ovarian Cyst of 21‐Year‐Old Young Woman
Authors: Kim Young Tae , Kim Jae Wook , Choe Byung Hoon 
Published: May 2010

AbstractHuge ovarian tumors are rarely seen in modern surgical practice. As health care education and access to hospitals have improved over the past 30 years, the number of these reports have become almost negligible. However, these huge ovarian tumors still present many challenge, even life‐threatening risks due to severe cardiovascular, pulmonary, and circulatory problems, including technical difficulties of surgery, massive hemorrhage, and postoperative complications. A knowledge of the deranged physiology and its management may avert these complications. We present the case of a 21‐year‐old woman with huge ovarian tumor. The total weight of the tumor was 136 pounds (62 kg). She was treated surgically with good results.
Uterine Leiomyoma in Pregnancy: Its Influence on Obstetric Performance
Authors: Koike Toshimitsu , Minakami Hisanori , Kosuge Shuichi , Usui Rie , Matsubara Shigeki , Izumi Akio , Sato Ikuo 
Published: May 2010

AbstractObjective: To assess the effects of uterine leiomyoma on obstetrical performance.Methods: We reviewed the medical records of 102 women with singleton pregnancies who were found ultrasonographically to have uterine leiomyomas during the first half of their pregnancy and who gave birth at our hospital at ≥ 22 weeks of gestation between January 1990 and December 1997.Results: The 102 women gave birth to 101 healthy infants, weighing 2,974 + 579 g at 38.8 + 2.6 weeks of pregnancy. One woman experienced an unexplained antepartum fetal death at 24 weeks of gestation. Bleeding at the first trimester occurred in 16% of the women. Pain localized in the lower abdomen and requiring relief occurred in 28% of the women during the first or second trimester. Tocolytic treatment was required in 25% of the pregnancies, and preterm delivery occurred in 12% thereof. A cesarean section was performed in 39% of the pregnancies. Bleeding ≥ 500 ml occurred at delivery in 48% of the cases. The largest fibroid, > 6 cm in diameter, which was seen in 51 women, was associated with higher frequencies of tocolytic treatment (41%), preterm delivery (24%), bleeding ≥ 500 ml at delivery (59%), and cesarean delivery (51%). In 76 women (75%) who attempted vaginal delivery, the obstetrical outcome was comparable to that of 115 control women who were matched regarding age, parity, and gestational week.Conclusions: Although pain in the lower abdomen, the requirement of tocolytic treatment, preterm delivery, and cesarean delivery were common, the neonatal outcome was fairly good in women with uterine leiomyomas. The present data might be encouraging to pregnant women with uterine leiomyomas.
Prenatal Diagnosis of Meckel Syndrome: A Case Report
Authors: Tongsong Theera , Piyamongkol Wirawit , Pongsatha Saipin 
Published: May 2010

AbstractObjective: To demonstrate the major sonographic findings associated with Meckel syndrome and to emphasize the importance of prenatal sonography in helping to establish the correct diagnosis.Subjects: Two fetuses with prenatal diagnosis of Meckel syndrome were sonographically evaluated.Results: Both fetuses were demonstrated to have evidence of renal cystic dysplasia, occipital cephalocele and postaxial polydactyly. One case was diagnosed at 16 weeks of gestation whereas the other was detected at 36 weeks. Of interest, the first case had only unilateral renal cystic dysplasia and contralateral renal agenesis and mild degree of oligohydramnios. The other related anomalies which were not detected prenatally included cerebellar hypoplasia in case 1 and micrognathia in case 2.Conclusion: The main sonographic findings included renal cystic dysplasia, occipital cephalocele and postaxial polydactyly.
Microsatellite Instability and hMSH2 Gene Mutation in a Triple Cancer (Colon Cancer, Endometrial Cancer, Ovarian Cancer) Patient in Hereditary Non‐Polyposis Colorectal Cancer (HNPCC) Kindred
Authors: Shigemasa Kazushi , Yokozaki Hiroshi , Honda Nao , Sakata Kenichirou , Oshita Takafumi , Nagai Nobutaka , Ohama Koso 
Published: May 2010

AbstractA patient who had triple cancer (colon cancer, endometrial cancer, and ovarian cancer) in HNPCC kindred is reported. Her family history revealed the occurrence of colon cancer in her paternal aunt and in two cousins, fulfilling the minimum HNPCC criteria. Microsatellite instability analysis revealed replication error (RER)' in all cancer lesions at 2 microsatellite loci (D1S191, BAT 40). SSCP analysis suggested germline mutation in exon 2 of the hMSH2 gene. This case showed the importance of complete family‐history investigations to identify HNPCC patients. In the near future, definitive diagnosis of HNPCC will be possible on the basis of DNA studies.
Effect of Labour and Delivery on Plasma Hepatic Enzymes in the Newborn
Authors: Mongelli Max , Kwan Yiu , Kay Law Lap , Hjelm Magnus , Rogers M. S. 
Published: May 2010

AbstractObjective: To study the relationship between cord blood hepatic enzymes and obstetric and neonatal outcome in a Chinese population.Materials and Methods: The study group consisted of 288 low‐risk Chinese women with singleton term pregnancies. The following enzymes were assayed in cord blood: lactate dehydrogenase (LDH), glutamyl transferase (GGT), aspartate aminotransferase (AST) and alanine transferase (ALT). These were correlated to maternal and neonatal characteristics.Results: A strong correlation was noted between cord blood AST and LDH (R = 0.582, p < 0.01), which was absent amongst those infants delivered by elective cesarean section. LDH, AST and ALT were negatively correlated with cord arterial pH and base excess (BE). GGT was inversely related only to gestational age (R = ‐ 0.18, p < 0.01). Both LDH and AST were weakly correlated with the duration of the first and second stages of labour. LDH was most closely linked to arterial pH, whereas AST was related to both arterial BE and duration of the second stage.Conclusions: The reference values are comparable to those published for Caucasian populations. There are moderate elevations in LDH and AST associated with the onset of labour and changes in acid‐base status.