bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Base‐Catalyzed Cascade 1,3‐H Shift/Cyclization Reaction to Construct Polyaromatic Furans.
Authors: Wang Ya‐Hui , Liu Heng , Zhu Li‐Li , Li Xiao‐Xiao , Chen Zili 
Published: June 2011

AbstractThe tandem process using base‐catalyzed 1,3‐H shift as the starting step is applicable to symmetrical aryl diynes (I) as well as unsymmetrical ones.
ChemInform Abstract: Nucleophilic Reactions of 9‐Isopropyl‐2,4‐dimethoxy‐7,12‐dimethyl‐3‐(phenylsulfonyl)benzo [a]heptalene with Lithium Dialkylamides.
Authors: El Rayes Samir , Linden Anthony , Abou‐Hadeed Khaled , Hansen Hans‐Juergen 
Published: June 2011

AbstractTreatment of the title compound (I) with lithium piperidide (II) leads to substitution of the two methoxy groups by piperidino substituents, whereas lithium diisopropylamide induces the formation of heptaleno‐annulated dibenzothiophenes (V) and (VI).
ChemInform Abstract: Domino Ligand‐Free Copper‐Catalyzed Synthesis of Polysubstituted Indoles.
Authors: Ali Md Ashif , Punniyamurthy Tharmalingam 
Published: June 2011

AbstractThe reaction of 2‐iodoanilines with 1,3‐dicarbonyl compounds affords a variety of polysubstituted indoles as subunits of natural products.
ChemInform Abstract: Iodobenzene‐Mediated Intramolecular Oxidative Coupling of Substituted 4‐Hydroxyphenyl‐N‐phenylbenzamides for the Synthesis of Spirooxindoles.
Authors: Yu Zhengsen , Ju Xuhui , Wang Junyan , Yu Wei 
Published: June 2011

AbstractA series of spirooxindoles (II) is readily prepared by an intramolecular oxidative coupling reaction of benzamides (I).
ChemInform Abstract: Asymmetric Friedel—Crafts Reaction of Indoles with Ethyl Trifluoropyruvate Using a Copper(I)‐Bisoxazolidine Catalyst.
Authors: Wolf Christian , Zhang Peng 
Published: June 2011

AbstractA range of indolyl trifluorohydroxypropanoates is produced in high yield and enantioselectivity in relatively short reaction times.
ChemInform Abstract: An Efficient, Ligand‐Free, Heterogeneous Supported Copper Hydroxide Catalyst for the Synthesis of N,N‐Bicyclic Pyrazolidinone Derivatives.
Authors: Yoshimura Kazuaki , Oishi Takamichi , Yamaguchi Kazuya , Mizuno Noritaka 
Published: June 2011

AbstractCycloaddition of a variety of azomethine imines with electron‐deficient terminal alkynes proceeds smoothly in the presence of a heterogeneous Cu(OH)x—Al2O3 catalyst to give bicyclic pyrazolidinone derivatives in high yields.
ChemInform Abstract: Copper‐Catalyzed Synthesis of 2‐Imidazolines and Their N‐Hydroxyethyl Derivatives under Various Conditions.
Authors: Zhang Jin , Wang Xiao , Yang Meipan , Wan Kerou , Yin Bing , Wang Yunxia , Li Jianli , Shi Zhen 
Published: June 2011

AbstractIt is demonstrated, that CIA is an efficient reusable catalyst for the synthesis of imidazolines under either thermal or microwave conditions.
ChemInform Abstract: Guiding the Nitrogen Nucleophile to the Middle: Palladium‐Catalyzed Decarboxylative Cyclopropanation of 2‐Alkylidenetrimethylene Carbonates with Isocyanates.
Authors: Shintani Ryo , Moriya Kohei , Hayashi Tamio 
Published: June 2011

AbstractThe decarboxylative cyclopropanation of carbonates (Va)—(Vh) gives rise to oxazolidinones (VII) as main or sole products, whilst the reaction of carbonate (Va) with phenyl isocyanate leads only to the allylic amination product (VIIIi).
ChemInform Abstract: Nitrosonium Hexachlorostannate: Synthesis, Crystal Structure, and Nitrosating Activity in the Reactions with Arylcyclopropanes.
Authors: Morozov I. V. , Bondarenko O. B. , Karpova E. V. , Pryadchenko A. S. , Korenev Yu. M. , Troyanov S. I. , Zyk N. V. 
Published: June 2011

Abstract(NO)2 [SnCl6] appears to be a mild nitrosating agent that can be successfully used for the synthesis of isoxazolines (II) from arylcyclopropanes (I) containing electron‐donor substituents in the aromatic ring.
ChemInform Abstract: Cobalt(I) Catalysis in the Diastereoselective Two‐Step Synthesis of Tricyclic Systems.
Authors: Erver Florian , Hilt Gerhard , Harms Klaus 
Published: June 2011

AbstractThe cobalt‐catalyzed cycloaddition reaction of dienes (I) with alkynes (II) and (VII) followed by a Knoevenagel—hetero—Diels—Alder multicomponent reaction of resulting cyclooctatrienes (III) and cyclohexa‐1,4‐dienes (VIII) with diones (IV) and formaldehyde leads to desired tricyclic pyran derivatives (VI) and (VIII), respectively.
ChemInform Abstract: Aromatic Electrophilic Substitution vs. Intramolecular Wittig Reaction: Vinyltriphenylphosphonium Salt Mediated Synthesis of 4‐Carboxyalkyl‐8‐formyl Coumarins.
Authors: Majumdar K. C. , Ansary Inul , Samanta Srikanta , Roy Brindaban 
Published: June 2011

AbstractOptimized reaction conditions using DMF as the solvent are developed to obtain the desired benzopyrans (III) exclusively.
ChemInform Abstract: Rhodium‐Catalyzed Enantioselective Addition of Boronic Acids to N‐Benzylnicotinate Salts.
Authors: Nadeau Christian , Aly Sara , Belyk Kevin 
Published: June 2011

AbstractUnder optimized conditions concerning the solvent, chiral ligand and rhodium complex, the addition of both aryl‐ and alkenylboronic acids proceeds with <90% regioselectivity toward the formation of 6‐ over 4‐substituted dihydropyridines.
ChemInform Abstract: 1‐(1‐Acetyl‐piperidin‐4‐yl)‐3‐adamantan‐1‐yl‐urea (AR9281) as a Potent, Selective, and Orally Available Soluble Epoxide Hydrolase Inhibitor with Efficacy in Rodent Models of Hypertension and Dysglycemia.
Authors: Anandan Sampath‐Kumar , et al. et al. 
Published: June 2011

AbstractThe synthesis of the clinical candidate (I) and its analogues is achieved via a library approach allowing the facile preparation of various left hand side and right hand side combinations around the piperidinyl urea nucleus.
ChemInform Abstract: Synthesis of Nicotinonitrile Derivatives and Study of Their Photophysical Properties.
Authors: Toche Raghunath B. , Kazi Muddassar A. , Nikam Prashant S. , Bhavsar Dinesh C. 
Published: June 2011

AbstractNicotinonitrile derivatives are conveniently obtained by a three‐component Dimroth reaction of chalcones, malononitrile, and secondary heterocyclic amines or sodium alcoholates.
ChemInform Abstract: Synthesis of Isoquinolines via Rhodium(III)‐Catalyzed Dehydrative C—C and C—N Coupling Between Oximines and Alkynes.
Authors: Zhang Xingping , Chen Dan , Zhao Miao , Zhao Jing , Jia Aiqun , Li Xingwei 
Published: June 2011

AbstractThe coupling proceeds under mild conditions using a low rhodium‐catalyst loading.
ChemInform Abstract: Basic Alumina Supported One‐Pot Synthesis of Structurally Diverse Pyridine/Quinolinine‐Fused Novel Diazepanium, Diazocanium, Imidazodilinium and Tetrahydro‐pyrimidiniums.
Authors: Mondal Nirup B. , et al. et al. 
Published: June 2011

AbstractThe reaction affords diversely fused cationic heterocycles as pharmacophores.
ChemInform Abstract: Synthesis, Reactions and Antibacterial Activity of 3‐Acetyl[1,2,4]triazolo[3,4‐a]isoquinoline Derivatives Using Chitosan as Heterogeneous Catalyst under Microwave Irradiation.
Authors: Hassaneen Hamdi M. , Hassaneen Huwaida M. E. , Mohammed Yasmin Sh. , Pagni Richard M. 
Published: June 2011

AbstractAntibacterial effects of title compounds (VII) and (VIII) are studied.
ChemInform Abstract: Synthesis and Evaluation of Novel Pyrimidine‐Based Dual EGFR/Her‐2 Inhibitors.
Authors: Suzuki Naoyuki , et al. et al. 
Published: June 2011

Abstract4‐Anilino‐5‐alkenyl or 5‐alkynyl‐6‐methylpyrimidine derivatives exhibiting inhibitory activity against both enzymes are identified.
ChemInform Abstract: Synthesis and Characterization of Substituted Pyrazino[2′,3′:4,5]thieno[3,2‐d]pyrimidines and Related Molecules.
Authors: Fernandez‐Mato Antonio , Peinador Carlos , Quintela Jose M. 
Published: June 2011

AbstractNitrile (III) is used as a convenient starting compound for the synthesis of a variety of fused pyrazine derivatives.
ChemInform Abstract: Stereoconvergent Synthesis of Chiral Allylboronates from an E/Z Mixture of Allylic Aryl Ethers Using a 6‐NHC—Cu(II) Catalyst.
Authors: Park Jin Kyoon , Lackey Hershel H. , Ondrusek Brian A. , McQuade D. Tyler 
Published: June 2011

AbstractThe six‐membered N‐heterocyclic carbene‐copper complex IQC catalyzes the asymmetric borylation of both the (E)‐ and (Z)‐isomer of an allylic m‐nitrophenyl ether to give the α‐substituted allylboronate with the same absolute configuration.
ChemInform Abstract: A Nickel‐Catalyzed Benzannulation Approach to Aromatic Boronic Esters.
Authors: Auvinet Anne‐Laure , Harrity Joseph P. A. 
Published: June 2011

AbstractIt is demonstrated, that alkynylborononates participate in regioselective Ni‐catalyzed benzannulation reaction with cyclobutenones to yield phenols which can be readily oxidized to p‐benzoquinones.
ChemInform Abstract: Copper(I)‐Catalyzed Regioselective Monoborylation of 1,3‐Enynes with an Internal Triple Bond: Selective Synthesis of 1,3‐Dienylboronates and 3‐Alkynylboronates.
Authors: Sasaki Yusuke , Horita Yuko , Zhong Chongmin , Sawamura Masaya , Ito Hajime 
Published: June 2011

AbstractThe regioselectivity is primarily determined by the substrate structure, whereas for moderately substituted 1,3‐enynes (IV), the catalytic phosphine ligand displays a significant role.
ChemInform Abstract: Highly Unsaturated Phosphorus Compounds: Trimeric and Dimeric Sulfides of a α,β‐Di‐tert‐butyl Vinyl Phosphaalkyne.
Authors: Ionkin Alex S. , Marshall William J. , Fish Brian M. 
Published: June 2011

AbstractThe first examples of sulfides of a 1,3,5‐triphosphabenzene are synthesized by sulfurization of parent phosphabenzene derivative (I).
ChemInform Abstract: A Two‐Step Practical Synthesis of Dehydroalanine Derivatives.
Authors: Perez‐Labrada Karell , Florez‐Lopez Edwin , Paz‐Morales Evelyn , Miranda Luis D. , Rivera Daniel G. 
Published: June 2011

AbstractThe synthesis of title compounds (VI) and (X) is achieved by Ugi four‐component reaction and subsequent elimination of the benzoate group.
ChemInform Abstract: An Improved Procedure for the Preparation of β‐Thiohydroximates for Glucosinolate Synthesis.
Authors: Cobb Susan E. , Morgan Kate F. , Botting Nigel P. 
Published: June 2011

AbstractA new coupling method for the formation of β‐thiohydroximate bonds involves in situ generation of an oximyl chloride from the corresponding oxime and inexpensive chlorine bleach followed by base‐mediated formation of nitrile oxides which react with thioglucopyranose (II).
ChemInform Abstract: Indium‐Mediated Allenylation of Aldehydes and Its Application in Carbohydrate Chemistry: Efficient Synthesis of D‐Ribulose and 1‐Deoxy‐D‐ribulose.
Authors: Fischer Michael , Schmoelzer Christoph , Nowikow Christina , Schmid Walther 
Published: June 2011

AbstractIndium‐mediated reaction of a diversity of aldehydes with bromobutynols (II) proceeds under ultrasonication to give the corresponding allene products, e.g. (III), (VIII), (XI) or (XIV).
ChemInform Abstract: Efficient Synthesis of Key Intermediate Toward Liphagal Synthesis.
Authors: Deore Vijaykumar , Lohar Manoj Kumar , Mundada Ramswaroop , Roychowdhury Abhijit , Vishwakarma Ram , Kumar Sanjay 
Published: June 2011

AbstractA facile method for the synthesis of the key intermediates (VI) and (VII) is presented starting from the inexpensive and readily available starting material 2,4,5‐trimethoxy benzaldehyde.
ChemInform Abstract: Synthesis and Antibacterial Evaluation of Novel 8‐Fluoro Norfloxacin Derivatives as Potential Probes for Methicillin and Vancomycin‐Resistant Staphylococcus aureus.
Authors: Sunduru Naresh , Gupta Leena , Chauhan Kuldeep , Mishra Nripendra N. , Shukla Praveen K. , Chauhan Prem M. S. 
Published: June 2011

AbstractNovel fluoroquinolones (I) are synthesized and evaluated for their antibacterial activity against K.
ChemInform Abstract: Design, Synthesis, and Biological Evaluation of Novel γ‐Carboline Ketones as Anticancer Agents.
Authors: Chen Jing , Liu Tao , Wu Rui , Lou Jianshu , Dong Xiaowu , He Qiaojun , Yang Bo , Hu Yongzhou 
Published: June 2011

AbstractA series of novel γ‐carboline ketones (I) is designed, synthesized and evaluated for their cytotoxic activity against several human cancer cell lines.
ChemInform Abstract: 2‐Acylamino‐5‐chlorobenzophenones with Enhanced Selectivity Towards Malaria Parasites.
Authors: Heinrich Swetlana , Altenkaemper Mirko , Bechem Benjamin , Perruchon Johann , Ortmann Regina , Dahse Hans‐Martin , Wang Yulin , Lanzer Michael , Schlitzer Martin 
Published: June 2011

AbstractSynthesis and SAR discussion are given.
ChemInform Abstract: 2‐Substituted 5,6‐Dimethyl‐3‐phenylsulfonyl‐pyrazolo[1,5‐a]pyrimidines: New Series of Highly Potent and Specific Serotonin 5‐HT6 Receptor Antagonists.
Authors: Ivachtchenko Alexandre V. , Golovina Elena S. , Kadieva Madina G. , Koryakova Angela G. , Mitkin Oleg D. , Tkachenko Sergey E. , Kysil Volodymyr M. , Okun Ilya 
Published: June 2011

AbstractSynthesis, biological evaluation, and SAR for novel title compounds (I) are disclosed.
Effects of Fenton Pre‐Treatment on Waste Activated Sludge Properties
Authors: Erden Gulbin , Filibeli Ayse 
Published: June 2011

AbstractFenton process was investigated for the purpose of biological sludge disintegration. The Box–Wilson experimental design was employed to evaluate the effects of major process variables (Fe(II) and H2O2 concentrations) on both disintegration and dewatering performance of sludge. Results showed that 4 g Fe(II)/kg total solids (TSs) and 60 g H2O2/kg TS are efficient for floc disintegration. Fenton pre‐treatment enhanced the biodegradability of sludge. For 4 g Fe(II)/kg TS and 60 g H2O2/kg TS, 19.4% higher methane production was achieved compared to raw sludge in biochemical methane potential assay. Fenton pre‐treatment resulted in the release of organic sludge components into the liquid phase. For 4 g Fe(II)/kg TS and 60 g H2O2/kg TS, dissolved organic carbon and total nitrogen in sludge's supernatant increased by 75.74 and 60.60%, respectively. Fenton pre‐treatment enhanced the filterability of sludge and it can be applied for conditioning purpose before mechanical dewatering units.
Physician over‐recommendation of mammography for terminally ill women
Authors: Leach Corinne R. , Klabunde Carrie N. , Alfano Catherine M. , Smith Judith Lee , Rowland Julia H. 
Published: June 2011

AbstractBACKGROUND:There has been recent, sometimes intense, debate about when to begin screening and how often to screen women for breast cancer with mammography. However, there should be no controversy regarding screening women who are unlikely to benefit from the procedure, such as those with a serious, life‐limiting illness who would not live long enough to benefit from the potential detection and treatment of breast cancer. Identifying characteristics of physicians who recommend mammography for terminally ill women can help guide efforts to minimize patient risks and make better use of health care resources.METHODS:The authors used data from a nationally representative survey of primary care physicians (PCPs) (N = 1196; response rate, 67.5%) conducted in 2006 and 2007 to examine PCPs' breast cancer screening recommendations for hypothetical patients ages 50 years, 65 years, and 80 years who were healthy, had a moderate comorbidity, or had a terminal comorbidity.RESULTS:Many PCPs (47.7%) reported that they would recommend mammography to a woman aged 50 years, 65 years, or 80 years with terminal lung cancer, indicating over‐recommendation. Physician characteristics associated with over‐recommending mammography included obstetrician/gynecologist (odds ratio [OR], 1.69) or internal medicine (OR, 0.45) specialty, being a woman (OR, 1.40), being a racial/ethnic minority (OR, 1.72), and working in a smaller practice (OR, 1.41).CONCLUSIONS:The current results indicated that physician over‐recommendation of screening mammography among terminally ill women is common. Certain physician and practice characteristics, including specialty, were associated with over‐recommending mammography. The authors concluded that an informed and shared mammography decision‐making process for terminally ill women may eliminate unnecessary patient risks and health care expenditures. Cancer 2012;. © 2011 American Cancer Society.
Retinal remodeling in the Tg P347L rabbit, a large‐eye model of retinal degeneration
Authors: Jones Bryan William , Kondo Mineo , Terasaki Hiroko , Watt Carl Brock , Rapp Kevin , Anderson James , Lin Yanhua , Shaw Marguerite Victoria , Yang Jia‐Hui , Marc Robert Edward 
Published: June 2011

AbstractRetinitis pigmentosa (RP) is an inherited blinding disease characterized by progressive loss of retinal photoreceptors. There are numerous rodent models of retinal degeneration, but most are poor platforms for interventions that will translate into clinical practice. The rabbit possesses a number of desirable qualities for a model of retinal disease including a large eye and an existing and substantial knowledge base in retinal circuitry, anatomy, and ophthalmology. We have analyzed degeneration, remodeling, and reprogramming in a rabbit model of retinal degeneration, expressing a rhodopsin proline 347 to leucine transgene in a TgP347L rabbit as a powerful model to study the pathophysiology and treatment of retinal degeneration. We show that disease progression in the TgP347L rabbit closely tracks human cone‐sparing RP, including the cone‐associated preservation of bipolar cell signaling and triggering of reprogramming. The relatively fast disease progression makes the TgP347L rabbit an excellent model for gene therapy, cell biological intervention, progenitor cell transplantation, surgical interventions, and bionic prosthetic studies. J. Comp. Neurol. 519:2713–2733, 2011. © 2011 Wiley‐Liss, Inc.
Expression analysis of the regenerating gene (Reg) family members Reg‐IIIβ and Reg‐IIIγ in the mouse during development
Authors: Matsumoto Sakiko , Konishi Hiroyuki , Maeda Rie , Kiryu‐Seo Sumiko , Kiyama Hiroshi 
Published: June 2011

AbstractThe regenerating gene/regenerating islet‐derived (Reg) family is a group of small secretory proteins. Within this family, Reg type‐III (Reg‐III) consists of: Reg‐IIIα, ‐β, ‐γ, and ‐δ. To elucidate the physiological relevance of Reg‐III, we examined the localization and ontogeny of Reg‐IIIβ and Reg‐IIIγ in mice at different time points spanning from embryonic day 13.5 to 7 weeks old, using in situ hybridization and immunohistochemistry. Our results showed that Reg‐IIIβ was expressed in specific subsets of primary sensory neurons and motor neurons, and that expression was transient during the embryonic and perinatal periods. Reg‐IIIβ expression was also observed in absorptive epithelial cells of the intestine. In contrast, Reg‐IIIγ expression was mainly observed in epithelial cells of the airways and intestine, but not in the nervous system, and expression levels showed a gradually increasing pattern along with development. In the airways Reg‐IIIγ was expressed in goblet and Clara‐like cells, whereas in the intestine Reg‐IIIγ was expressed in the absorptive epithelial cells and Paneth cells, and was found to be expressed in development before these organs had been exposed to the outside world. The present findings imply that Reg‐IIIβ and Reg‐IIIγ expression is regulated along divergent pathways. Furthermore, we also suggest that expression of Reg‐IIIγ in the airway and intestinal epithelia may occur to protect these organs from exposure to antigens or other factors (e.g., microbes) in the outer world, whereas the transient expression of Reg‐IIIβ in the nervous system may be associated with the development of the peripheral nervous system including such processes as myelination. J. Comp. Neurol., 2012;520:479–494. © 2011 Wiley Periodicals, Inc.
Tuning of Photocatalytic Hydrogen Production and Photoinduced Intramolecular Electron Transfer Rates by Regioselective Bridging Ligand Substitution
Authors: Karnahl Michael , Kuhnt Christian , Ma Fei , Yartsev Arkady , Schmitt Michael , Dietzek Benjamin , Rau Sven , Popp Jürgen 
Published: June 2011

AbstractArtificial photosynthesis based on supramolecular photocatalysts offers the unique possibility to study the molecular processes underlying catalytic conversion of photons into chemical fuels in great detail and to tune the properties of the photocatalyst by alterations of the molecular framework. Herein we focus on both possibilities in studying the photocatalytic reduction of protons by derivatives of the well‐known photocatalyst [(tbbpy)2Ru(tpphz)PdCl2](PF6)2 [4,4′‐di‐tert‐butyl‐2,2′‐bipyridine (tbbpy), tetrapyrido[3,2‐a:2′,3′‐c:3′′,2′′‐h:2′′′,3′′′‐j]phenazine (tpphz)]. We report on a modified photocatalyst where the crucial bridging ligand tpphz is substituted by bromine and investigate the effect of the structural variation on the catalytic properties of the complex and its ultrafast intramolecular charge transfer behavior. It is found that structural modification stabilizes the phenanthroline‐centered metal‐to‐ligand charge‐transfer state on the tpphz moiety, thereby reducing the electron transfer gradient across the entire electron‐relaying bridging ligand and at the same time accelerating nanosecond ground‐state recovery. The same structural modifications cause an overall reduction of the catalytic activity of the complex. Thus, the results highlight the potential of small structural variations in the molecular framework of supramolecular catalysts in understanding the photoinduced charge‐transfer processes and optimizing their catalytic performance.
Mechanism of increase of electrostatic charging tendency in insulating oil for oil‐immersed transformer
Authors: Okabe Sigemitsu , Kotoh Masanori , Tsuchie Motoo , Amimoto Tsuyoshi 
Published: June 2011

AbstractThe mechanism of the increase in the electrostatic charging tendency (ECT) of insulating oil and causative compounds were investigated by accelerated deterioration tests with the addition of various compounds. Although the ECT of the insulating oil was almost constant when only sulfoxide compounds were added, a marked increase was observed when either hydrochloric acid or moisture, which was considered to be generated by the aging of insulating oil, was also added to oil containing sulfoxide compounds. It is assumed that the sulfonium ion, which is generated by the reaction between sulfoxide compounds and hydrogen ion, is the compound that directly contributes to the increase in the ECT. Hydrogen ions can be supplied from organic acids generated by the oxidation of hydrocarbons in aging insulating oil. It is considered that the increase in the ECT of insulating oil is caused by the generation of sulfoxides by the oxidation of sulfide, which are present in fresh oil (originating compounds), and the generation of sulfonium ions by a reaction between sulfoxide and hydrogen ions, which are formed during aging. © 2011 Wiley Periodicals, Inc. Electr Eng Jpn, 176(4): 26–33, 2011; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.21113
Design of multi‐input multi‐output delay time control system with feedforward compensation
Authors: Tomaru Takao , Mori Yasuchika 
Published: June 2011

AbstractIn this paper, for the design of delay time control systems the minimum‐phase state of the controlled object is considered. By feedback on the observed minimum‐phase state, the control system can be stabilized, diminishing the effect of delay times. Feedforward compensation offers the possibility of canceling the delay times in the input–output characteristics. For delay time control systems decoupling control is necessary, and the design of a decoupling tandem compensator with the minimum degree is shown. Feedback on the observed minimum‐phase state and feedforward compensation are also useful for delay time decoupling control systems. A numerical example for a two‐input two‐output controlled object with delay time characteristics is presented and decoupling control with feedforward compensation is designed. © 2011 Wiley Periodicals, Inc. Electr Eng Jpn, 176(4): 34–44, 2011; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.21118