bluuebunny/crossref_metadata_2025_split huggingface dataset:
Same, but different: similar states of forest structure in temperate mountain regions of Europe despite different social-ecological forest disturbance regimes
Authors: Stritih Ana , Senf Cornelius , Kuemmerle Tobias , Munteanu Catalina , Dzadzamia Lasha , Stritih Jernej , Matijašić Dragan , Cortner Owen , Seidl Rupert 
Published: June 2024

Abstract
Context
Ecosystem services provided by mountain forests are critically linked to forest structure. Social-ecological disturbance regimes (i.e., the rate, frequency, and patch size distribution of disturbances driven by interacting natural and anthropogenic processes) and land use affect forest structure, but their specific impacts are not fully understood.

Objectives
We examine how differences in disturbance regimes affect patterns of forest structure across three European mountain ranges with similar vegetation types but different land-use histories: the European Alps, the Carpathians, and the Caucasus.

Methods
We related data on horizontal and vertical forest structure, measured by spaceborne lidar (GEDI), with Landsat-derived information on forest disturbances (1986–2020) and topographic, climatic, and anthropogenic predictors.

Results
We found similar social-ecological disturbance regimes in the Alps and Carpathians (average annual disturbance rates of 0.34% and 0.39%, respectively, and median patch size < 0.5 ha), yet much lower disturbance rates and patch sizes in the Caucasus (0.08% yr−1 and < 0.2 ha). Despite different disturbance regimes, we found similar patterns of forest structure. Two alternative states emerged consistently across all mountain ranges: a tall and closed-canopy state in 74–80% of forests and a low and open-canopy state (< 50% canopy cover) in the rest. While forest structure responded consistently to abiotic drivers such as topography and climate, its association with anthropogenic pressures differed between mountain ranges. Stand-replacing disturbances played an important role in the Carpathians, while forest structure in the Caucasus was related to proximity to settlements, reflecting local forest use.

Conclusions
Different social-ecological contexts in mountain regions can produce markedly different forest disturbance regimes. Despite these differences, similar states of forest structures emerge, suggesting strong attractors of structure in temperate mountain forests.
Preventing Type 2 Diabetes after Gestational Diabetes: A Systematic Review Mapping Physical Activity Components using the Socio-Ecological Model
Authors: Ioannou Elysa , Humphreys Helen , Homer Catherine , Purvis Alison 
Published: June 2024

Abstract
Objectives
Gestational diabetes commonly occurs during pregnancy and increases lifetime risk of type 2 diabetes following pregnancy. Engaging in physical activity postnatally can reduce this subsequent risk. Interventions aiming to increase physical activity after gestational diabetes may not address the wide range of post-pregnancy barriers. A socio-ecological approach highlights the need to include multi-level factors such as social, community and organisational factors. The aim of the review was to map intervention components to prevent type 2 diabetes after gestational diabetes using the socio-ecological model as a framework and investigate how physical activity changes align with different intervention components utilised.

Methods
Eligible studies included any study type within 5 years of a gestational diabetes diagnosis and targeted physical activity. A systematic search of MEDLINE, Cochrane Library, Web of Science, CINAHL Complete, and Scopus was conducted in October 2022. Results were categorised based on whether findings demonstrated no increases, non-statistically significant increases or statistically significant increases in physical activity.

Results
Forty-eight studies were included (37 different interventions). Thirty-eight studies were assessed as “adequate” quality, only two studies were “good” quality, and the remaining were limited quality. Mixed physical activity outcomes were observed across components used at the intrapersonal level, with components across other levels of the socio-ecological model showing more increases in physical activity. Intervention components within the social and organisational levels, for example childcare provision, providing group-based sessions and offering remote delivery, were more often present in interventions with physical activity increases.

Conclusions for Practice
Future interventions targeting physical activity after gestational diabetes should aim to include social and organisational-level components in their intervention design.
This systematic review was registered in PROSPERO (ID: CRD42021272044).
Design and performance evaluation of UCX for the Tofu Interconnect D on Fugaku towards efficient multithreaded communication
Authors: Watanabe Yutaka , Tsuji Miwako , Murai Hitoshi , Boku Taisuke , Sato Mitsuhisa 
Published: June 2024

AbstractThe increasing trend of manycore processors makes multithreaded communication more important to avoid costly global synchronization among cores. One of the representative approaches that require multithreaded communication is the global task-based programming model. In the model, a program is divided into tasks, and tasks are asynchronously executed by each node, and independent thread-to-thread communications are expected. However, the Message passing interface (MPI) based approach is not efficient because of design issues. In this research, we design and implement the utofu transport layer in an abstracted communication library called Unified communication-X (UCX) for efficient remote direct memory access (RDMA) based multithreaded communication on Tofu Interconnect D. The evaluation results on Fugaku show that UCX can significantly improve the multithreaded performance over MPI, while maintaining portability between systems thanks to UCX. UCX shows about 32.8 times lower latency than Fujitsu MPI with 24 threads in the multithreaded pingpong benchmark and about 37.8 times higher update rate than Fujitsu MPI with 24 threads on 256 nodes in multithreaded GUPs benchmark.
Unraveling the link between cardiorespiratory fitness and cancer: a state-of-the-art review
Authors: Kunutsor Setor K. , Kaminsky Leonard A. , Lehoczki Andrea , Laukkanen Jari A. 
Published: June 2024

AbstractCardiorespiratory fitness (CRF) not only reflects an individual’s capacity to perform physical activities but also encapsulates broader effects on the basic biology of aging. This review aims to summarize the evidence on the influence of CRF on overall and site-specific cancer risks. It delves into the biological mechanisms through which CRF may exert its effects, explores the clinical implications of these findings, identifies gaps in the current evidence base, and suggests directions for future research. The synthesis of findings reveals that higher CRF levels (general threshold of > 7 METs) are consistently associated with a reduced risk of a range of cancers, including head and neck, lung, breast, gastrointestinal, particularly pancreatic and colorectal, bladder, overall cancer incidence and mortality, and potentially stomach and liver, bile duct, and gall bladder cancers. These inverse associations between CRF and cancer risk do not generally differ across age groups, sex, race, or adiposity, suggesting a universal protective effect of CRF. Nonetheless, evidence linking CRF with skin, mouth and pharynx, kidney, and endometrial cancers is limited and inconclusive. Conversely, higher CRF levels may be potentially linked to an increased risk of prostate cancer and hematological malignancies, such as leukemia and myeloma, although the evidence is still not conclusive. CRF appears to play a significant role in reducing the risk of several cancers through various biological mechanisms, including inflammation reduction, immune system enhancement, hormonal regulation, and metabolic improvements. Overall, enhancing CRF through regular physical activity offers a vital, accessible strategy for reducing cancer risk and extending the health span. Future research should aim to fill the existing evidence gaps regarding specific cancers and elucidate the detailed dose–response relationships between CRF levels and cancer risk. Studies are also needed to elucidate the causal relationships and mechanistic pathways linking CRF to cancer outcomes.
The Promising Role of Selenium and Yeast in the Fight Against Protein Amyloidosis
Authors: Kieliszek Marek , Sapazhenkava Katsiaryna 
Published: June 2024

AbstractIn recent years, increasing attention has been paid to research on diseases related to the deposition of misfolded proteins (amyloids) in various organs. Moreover, modern scientists emphasise the importance of selenium as a bioelement necessary for the proper functioning of living organisms. The inorganic form of selenium—sodium selenite (redox-active)—can prevent the formation of an insoluble polymer in proteins. It is very important to undertake tasks aimed at understanding the mechanisms of action of this element in inhibiting the formation of various types of amyloid. Furthermore, yeast cells play an important role in this matter as a eukaryotic model organism, which is intensively used in molecular research on protein amyloidosis. Due to the lack of appropriate treatment in the general population, the problem of amyloidosis remains unsolved. This extracellular accumulation of amyloid is one of the main factors responsible for the occurrence of Alzheimer’s disease. The review presented here contains scientific information discussing a brief description of the possibility of amyloid formation in cells and the use of selenium as a factor preventing the formation of these protein aggregates. Recent studies have shown that the yeast model can be successfully used as a eukaryotic organism in biotechnological research aimed at understanding the essence of the entire amyloidosis process. Understanding the mechanisms that regulate the reaction of yeast to selenium and the phenomenon of amyloidosis is important in the aetiology and pathogenesis of various disease states. Therefore, it is imperative to conduct further research and analysis aimed at explaining and confirming the role of selenium in the processes of protein misfolding disorders. The rest of the article discusses the characteristics of food protein amyloidosis and their use in the food industry. During such tests, their toxicity is checked because not all food proteins can produce amyloid that is toxic to cells. It should also be noted that a moderate diet is beneficial for the corresponding disease relief caused by amyloidosis.
Diabetes and obesity: the role of stress in the development of cancer
Authors: Avogaro Angelo 
Published: June 2024

AbstractDiabesity is a condition where an individual has both diabetes and obesity, which can lead to severe complications including cardiovascular disease, a leading cause of mortality. Recently, cancer has become a leading cause of excess hospitalizations, and both diabetes and obesity are associated with a higher risk of developing several types of cancer. In this review, we propose that chronic stress significantly increases this association. Managing diabetes and obesity is challenging as they both cause significant distress. The relationship between stress and cancer is interconnected, with anxiety and depression being common in cancer patients. Cancer diagnosis and treatment can cause lasting changes in the body’s neuroendocrine system, with stress causing an excessive release of catecholamines and prostaglandins in patients undergoing cancer surgery, which promotes the spread of cancer to other parts of the body. Furthermore, stress could significantly increase the risk of cancer in patients with diabetes, obesity, or both.
Clinical features and potential markers of disease in idiopathic non-histaminergic angioedema, a real-life study
Authors: Mormile Ilaria , Gigliotti Maria Celeste , Ferrara Anne Lise , Gatti Roberta , Spadaro Giuseppe , de Paulis Amato , Loffredo Stefania , Bova Maria , Petraroli Angelica 
Published: June 2024

AbstractIdiopathic non-histaminergic acquired angioedema (InH-AAE) is a rare disease, with unknown etiology and pathogenesis, characterized by recurrent clinical manifestations and resistance to antihistamines and corticosteroids. We aim to evaluate clinical features and potential markers of disease in an Italian cohort of patients with InH-AAE. We enrolled 26 patients diagnosed with InH-AAE. Information about clinical features, treatments, routine laboratory investigations, immunological and genetic tests were collected. We assessed plasma levels of complement components, angiogenic and lymphangiogenic mediators, proinflammatory cytokines and chemokines, and activity of phospholipases A2. Finally, patients underwent nailfold videocapillaroscopy (NVC); both quantitative and qualitative capillaroscopic parameters were analyzed. Plasma levels of VEGFs were similar in healthy controls and in InH-AAE patients. ANGPT1 was decreased in InH-AAE patients compared to controls while ANGPT2 was similar to controls. Interestingly, the ANGPT2/ANGPT1 ratio (an index of vascular permeability) was increased in InH-AAE patients compared to controls. sPLA2 activity, elevated in patients with C1-INH-HAE, showed differences also when measured in InH-AAE patients. TNF-α concentration was higher in InH-AAE patients than in healthy controls, conversely, the levels of CXCL8, and IL-6 were similar in both groups. At the NVC, the capillary loops mainly appeared short and tortuous in InH-AAE patients. InH-AAE represents a diagnostic challenge. Due to the potential life-threatening character of this condition, a prompt identification of the potentially bradykinin-mediated forms is crucial. A better comprehension of the mechanism involved in InH-AAE would also lead to the development of new therapeutic approaches to improve life quality of patients affected by this disabling disease.
Invertebrate Responses to Large- and Small-Scale Drivers in Coastal Phragmites australis Beds in the Northern Baltic Sea
Authors: Eveleens Maarse Floriaan , Gagnon Karine , Snickars Martin , Salovius-Laurén Sonja 
Published: June 2024

AbstractPhragmites australis is a common helophyte, covering much of the sheltered and shallow soft bottoms along the coasts of the Baltic Sea. Despite the expansion of P. australis over the past decades, there is little information on aquatic macroinvertebrates within P. australis beds. In this study, we examined the effect of large-scale (wave exposure, nutrients) and small-scale (distance from the seaward edge, live and dead stalk density, epiphyte and rhizome biomass) drivers on the density, taxa richness, diversity, and community structure of epifauna and infauna in monospecific P. australis beds around the Åland Islands and the Archipelago Sea. We found that higher wave exposure and nutrient levels generally supported higher epi- and infauna abundance and taxa richness. The effects on Shannon–Wiener diversity were less evident apart from an increase of the infauna diversity in the Archipelago Sea with increasing nutrient levels. On a local scale, the distance from the seaward edge, live and dead stalk density, and epiphyte biomass had varying effects on both epi- and infauna communities in the different regions. Rhizome biomass had no effect on either the epi- or infauna abundance, taxa richness, or diversity. Furthermore, according to existing studies, other habitats, e.g., Zostera marina meadows, Fucus vesiculosus belts, and vegetated soft-bottomed shallow bays, are generally characterized by more abundant fauna, except for the infauna, which had a higher density in P. australis beds than in vegetated soft-bottomed shallow bays. P. australis are a widespread, expanding, and understudied habitat with an important role in supporting coastal biodiversity.
Microtopographic Variation as a Potential Early Indicator of Ecosystem State Change and Vulnerability in Salt Marshes
Authors: Smith Alexander J. , Guntenspergen Glenn R. , Carr Joel A. , Walters David C. , Kirwan Matthew L. 
Published: June 2024

AbstractAs global climate change alters the magnitude and rates of environmental stressors, predicting the extent of ecosystem degradation driven by these rapidly changing conditions becomes increasingly urgent. At the landscape scale, disturbances and stressors can increase spatial variability and heterogeneity — indicators that can serve as potential early warnings of declining ecosystem resilience. Increased spatial variability in salt marshes at the landscape scale has been used to quantify the propagation of ponding in salt marsh interiors, but ponding at the landscape scale follows a state change rather than predicts it. Here, we suggest a novel application of commonly collected surface elevation table (SET) data and explore millimeter-scale marsh surface microtopography as a potential early indicator of ecosystem transition. We find an increase in spatial variability using multiple metrics of microtopographic heterogeneity in vulnerable salt marsh communities across the North American Atlantic seaboard. Increasing microtopographic heterogeneity in vulnerable salt marshes mirrored increasing trends in variance when a tipping point is approached in other alternative stable state systems — indicating that early warning signals of marsh drowning and ecosystem transition are observable at small-spatial scales prior to runaway ecosystem degradation. Congruence between traditional and novel metrics of marsh vulnerability suggests that microtopographic metrics can be used to identify hidden vulnerability before widespread marsh degradation. This novel analysis can be easily applied to existing SET records expanding the traditional focus on vertical change to additionally encapsulate lateral processes.
Generic load regulation strategy for enhancing energy efficiency of chiller plants
Authors: Wan Hang , Gong Yuyang , Wang Shengwei , Sun Yongjun , Xu Tao , Huang Gongsheng 
Published: June 2024

AbstractIn many chiller plants, high coefficient of performance (COP) is only achieved at a few favorable part load ratios (PLRs), while the COP is low at many other non-favorable PLRs. To address this issue, this study proposes a generic load regulation strategy that aims to maintain chiller plants operating at high COP, particularly under non-favorable PLRs. This is achieved by incorporating thermal energy storage (TES) units and timely optimizing the charging and discharging power of the integrated TES units. The optimal charging and discharging power is determined by solving a dynamic optimization problem, taking into account the performance constraints of the TES units and the chiller plants. To provide an overview of the energy-saving potential of the proposed strategy, a comprehensive analysis was conducted, considering factors such as building load profiles, COP/PLR curves of chillers, and attributes of the TES units. The analysis revealed that the proposed load regulation strategy has the potential to achieve energy savings ranging from 5.7% to 10.8% for chiller plants with poor COPs under unfavorable PLRs, particularly in buildings with significant load variations.
Agent-based decision-support model for bus route redesign in networks of small cities and towns: case study of Agder, Norway
Authors: Rasca Sinziana I. , Hu Bin , Biesinger Benjamin , Prandtstetter Matthias 
Published: June 2024

AbstractSmall cities and towns often struggle to provide high-quality public transport services to daily commuters. This is reflected in the modal split, where the share of car users dominates. Such a problem requires a modern solution, where transport planners can verify the impact of potential transport network improvements on the travel behavior of the residents before the changes are actually deployed. This study aims to demonstrate the usefulness of employing an agent-based simulation tool in the decision process for redesigning an express service regional bus route connecting a network of small cities and towns. The model was initially developed as a Mobility as a Service simulation solution for suburban areas of European metropolises. The model is adapted and applied to a case study for the region of Agder, Norway, simulating the impact of nine different scenarios on the patronage of a specific bus route. The simulation model proposes to upgrade the classic agent structure to a persona profile designed specifically for the case study. The main objective of this research is to identify the scenario that maximizes patronage while minimizing total route travel time and additional costs. The results suggest that the proposed model can be successfully adapted from suburban metropolitan areas to the realities of the considered case study, and potentially other similar regions. Specifically, out of the nine proposed scenarios, the model identified four promising ones. One of the four scenarios also fits the cost constraints imposed by the transport provider. The model provides a solid approach for analyzing complex transport systems that are practically impossible to consider in detail if the analysis is done without computer support. Thus, the results can be used as a decision support system for public transport planning and operations in networks of small cities and towns.
Geriatric Facial Dermatosis
Authors: Flowers R. Hal , Im Grace Y. , Jowdy Peter , Cohen Olivia G. , Lanyi Shira , Omesiete Wilson 
Published: June 2024

Abstract
Purpose of Review
The objective of this review is to identify and describe common facial dermatoses in the geriatric population. This review includes relevant clinical presentation, statistical data (when available), pathogenesis, differential diagnosis, associated systemic diseases, updated treatment recommendations, and recent advances in the field.

Recent Findings
Several medications including biological agents were recently approved by Food and Drug Administration (FDA) for treating skin diseases in general population. However, limited research data are available for the geriatric population. The choice of treatment should be guided by factors such as the specific disease type, locations of the lesions, patients’ comorbidities, and their individual preferences.

Summary
Recognizing and addressing facial dermatosis is becoming more crucial as the elderly population is projected to increase in the coming decades. Healthcare providers should familiarize themselves with common facial dermatoses that affect the elderly, enabling them to deliver appropriate care to enhance patients’ well-being. Managing skin dermatoses requires a comprehensive evaluation, considering the patient's comorbidities and polypharmacy, ruling out differential diagnoses, and meticulously assessing the risks and benefits of potential interventions. Future research should prioritize evaluating the effectiveness and safety of treatments specifically tailored for the geriatric population.