bluuebunny/crossref_metadata_2025_split huggingface dataset:
Premature aging in aneuploid yeast is caused in part by aneuploidy-induced defects in Ribosome Quality Control
Authors: Escalante Leah E. , Hose James , Howe Hollis , Paulsen Norah , Place Michael , Gasch Audrey P. 
Published: June 2024

ABSTRACTPremature aging is a hallmark of Down syndrome, caused by trisomy of human chromosome 21, but the reason is unclear and difficult to study in humans. We used an aneuploid model in wild yeast to show that chromosome amplification disrupts nutrient-induced cell-cycle arrest, quiescence entry, and healthy aging, across genetic backgrounds and amplified chromosomes. We discovered that these defects are due in part to aneuploidy-induced dysfunction in Ribosome Quality Control (RQC). Compared to euploids, aneuploids entering quiescence display aberrant ribosome profiles, accumulate RQC intermediates, and harbor an increased load of protein aggregates. Although they have normal proteasome capacity, aneuploids show signs of ubiquitin dysregulation, which impacts cyclin abundance to disrupt arrest. Remarkably, inducing ribosome stalling in euploids produces similar aberrations, while up-regulating limiting RQC subunits or proteins in ubiquitin metabolism alleviates many of the aneuploid defects. Our results provide implications for other aneuploidy disorders including Down syndrome.
Differences in sensory nerve block between levobupivacaine and bupivacaine at low concentrations in humans and animals
Authors: Sakamoto Akiyuki , Tanaka Satoshi , Ishida Takashi , Kawamata Mikito 
Published: June 2024

AbstractPhysiochemical properties of levobupivacaine and bupivacaine are identical, but pharmacokinetic and pharmacodynamics properties differ due to stereoselective interactions at the molecular sites of action. An evaluation of nerve block characteristicsis essential for optimal clinical application. This study compared the sensory blocking characteristics of levobupivacaine to bupivacaine in humans and model animals. Levobupivacaine and bupivacaine were compared for sensory block efficacy using a randomized, double-blinded, crossover study design. Eighteen healthy volunteers were randomized to receive levobupivacaine or bupivacaine by subcutaneous injection into the forearm, followed by the other drug 1 week later with injection order counterbalanced across subjects. Tactile detection and mechanical pain thresholds were determined using von Frey hairs and thermal pain threshold using a thermal stimulator. Effects of levobupivacaine and bupivacaine, on the spiking activity of spinal dorsal horn (SDH) neurons evoked by innocuous or noxious stimuli were also compared in anesthetized Sprague–Dawley rats by in vivo extracellular recordings. There were no significant differences in mechanical and thermal pain thresholds following levobupivacaine or bupivacaine injection at 0.025%, 0.0625%, and 0.125%. There was also no significant difference in tactile detection threshold following levobupivacaine or bupivacaine injection at 0.125%. However, tactile detection threshold was significantly higher after administration of bupivacaine at 0.025% and 0.0625% compared to equivalent doses of levobupivacaine. Subcutaneous injection of bupivacaine at 0.05% also induced significantly greater inhibition of SDH neuron spiking activity evoked by innocuous stimuli compared to an equivalent dose of levobupivacaine, while there was no significant difference in suppression of spiking activity evoked by noxious stimuli. Low-dose bupivacaine induces greater suppression tactile sensation than low-dose levobupivacaine. Thus, low-dose levobupivacaine demonstrates relatively greater blocking selectivity for noxious over innocuous stimuli compared to low-dose bupivacaine. Levobupivacaine may be advantageous for applications where pain must be suppressed but non-nociceptive sensations maintained.
Influence of wind direction on flow over a cliff and its interaction with a wind turbine wake
Authors: Dar Arslan Salim , Porté-Agel Fernando 
Published: June 2024

This work investigates the effect of wind direction on the flow over a cliff and its interaction with the wake of a wind turbine sited on the cliff. The cliff is modeled as a forward-facing step, and five wind directions are tested (θ=0∘, 15∘, 30∘, 45∘, and −45∘), where 0∘ represents a wind direction perpendicular to the cliff edge. The flow becomes increasingly three-dimensional with the increase in the wind direction magnitude and a cross-stream flow separation develops from the cliff leading edge. The turbulence kinetic energy decreases for wind directions higher than 15∘, which is due to the absence of the streamwise flow separation for higher wind directions. The cross-stream flow development in the base flow affects the shape of the turbine wake. A two-dimensional Gaussian fit is performed on the wake velocity deficit, which shows a slight departure from self-similarity in the lateral direction. The wake recovery slows down for wind directions higher than 15∘, which is consistent with the decrease in the wake growth rate for θ>15∘. The wake shows higher deflection and tilt angle for higher wind directions. Analysis of the streamwise momentum in the wake reveals that the advection terms play a role in slowing the wake recovery for higher wind directions.

Published by the American Physical Society
2024
Should I voice to improve workplace practices?
Authors: Rani Hira , Syed Obed Rashdi , Amin Muslim , Umrani Waheed Ali , Herjanto Halimin 
Published: June 2024

PurposeThis study attempts to examine how employee orientations and paranoid arousal intersect and influence the voice behaviors of employees, as they significantly influence workplace practices.Design/methodology/approachDrawing on a multi-source and multi-time-based survey, the data were collected from 37 supervisors and 270 employees in 80 branches of 11 microfinance banks. SmartPLS-4.1 was used to test the measurement and structural model. A total of 307 questionnaires were used for the data analysis.FindingsThis research presents the contrasting results of employee orientations with voice behavior. Results support the direct relationship between paranoid arousal and promotive-prohibitive voice behaviors. However, no support was found for approach-avoidance orientation and promotive-prohibitive voice behaviors.Practical implicationsEmployees' ability to voice-out in organizations depends on several motivational factors, consolidated into three areas – organizational culture, leadership, and individual traits. Organizations must implement a culture of transparency and open communication. Participative and inclusive leadership styles increase the quality of relationships with employees, stimulating a promotive voice. A support system for employees is needed to advance in their careers, increasing promotive behaviors.Originality/valueThe study adds value to the existing body of knowledge by studying approach-avoidance orientations and voice behaviors through the lens of paranoid arousal in the framework.
Healthcare service quality: a systematic review based on PRISMA guidelines
Authors: Rauf Abdul , Muhammad Norhilmi , Mahmood Hamid , Aftab Muhammad 
Published: June 2024

PurposeThe primary objective of this study is to conduct a comprehensive literature review focused on the concept of service quality within the healthcare sector. This research aims to categorize and analyze the various dimensions associated with service quality.Design/methodology/approachThe systematic literature review methodology was employed to accomplish current study goals, and specific criteria were utilized to select relevant research articles spanning the years from 2000 to 2023. Ultimately, 57 articles met the criteria and were included in the study.FindingsThrough a meticulous review of selected articles, our research identified and categorized 29 distinct measures for evaluating service quality in the healthcare sector. These measures were further grouped into five overarching categories, namely: overall service quality, personal characteristics, healthcare facility administration, patient attributes and the servicescape. Our investigation highlighted that the dimensions commonly utilized to assess service quality in healthcare primarily draw from the SERVQUAL framework. Additionally, there is significant emphasis on measurements related to the physical environment's quality, overall patient satisfaction and behavioral intention.Originality/valueThis review offers original value by synthesizing diverse literature on healthcare service quality, highlighting SEVQUAL dimensions and critical variables used for assessment. It provides insight into the subjective nature of service quality and varied sampling methods and contributes to enhancing service quality and patient satisfaction in healthcare settings.
The audit expectations gap firms listed on the Palestine Stock Exchange: empirical evidence on Palestinian stakeholders
Authors: Faza’ Mustafa , Badwan Nemer , Hamdan Montaser 
Published: June 2024

Purpose
The purpose of this study is to empirically evaluate the audit expectations gap among stakeholders in listed firms in Palestine. The purpose of the investigation is to determine whether or not there is a gap in audit expectations between auditors and investors, auditors and board directors, as well as among auditors and financial managers and also among auditors and shareholders.

Design/methodology/approach
To attain its ultimate objective, this study was created using an exploratory descriptive methodology grounded in the use of quantitative methods. A structured questionnaire was used to gather study data from 81 respondents, and a statistical package for the social sciences-26 was then used for analysis.

Findings
The results of this research showed that there is a sizable difference in audit expectations among shareholders, financial managers and board directors, as well as among auditors and investors. The findings also demonstrate that, in comparison to the difference between auditors and financial managers, the gap between auditors and board directors and auditors and shareholders is very narrow.

Research limitations/implications
This investigation, which examines the audit expectations gap in great detail, has some significant limitations. This study was limited to the Palestinian market alone. Future research might compare or examine the variations in audit expectations in Jordan, Lebanon, Syria, Iraq and Iran, among different countries. In addition, the demand for accurate and reliable financial reports has sparked a recent increase in interest in auditing, a long-standing sector that has expanded in recent years.

Practical implications
The study has several practical implications, for example, it underlines how crucial it is to make stakeholders aware of the limitations and difficulties related to the auditing process. By doing this, the situation that audit committees and listed firms find themselves in will be easier for investors, board directors, financial managers and shareholders to understand. The way that auditors and stakeholders communicate can help reduce this gap since it affects how much each party underestimates or understates the other’s obligations.

Originality/value
This paper contributes to the literature by analysing and identifying the causes of the audit expectations gap in companies listed on the Palestine Stock Exchange and providing useful insights and potential solutions to close or mitigate it. It also adds a new contribution to the literature related to the audit expectation gap. This investigation offers unambiguous evidence of a sizable discrepancy between audit expectations and actual performance in terms of formal auditor obligations as outlined by current law, as well as auditor reliability standards and practices, between auditors, board directors, investors, shareholders and financial managers in listed Palestinian firms.
A research on the Italian fiscal shell companies turnover
Authors: Pellegrini Antonio 
Published: June 2024

Purpose
The purpose of this paper is to study the turnover of Italian shell companies (SCs)/missing traders used for tax crimes, a predicate offence of money laundering. This research could be useful for Italian obliged entities to the Anti-Money Laundering Law to detect and report SCs, as soon as possible, to the Financial Intelligence Unit for Italy.

Design/methodology/approach
The author uses a sample of 32 SCs that are present in the Third Penal Section of the Italian Supreme Court in the period 2018–2020, involved in tax crimes and that have presented their balance sheets for two or more years. For SCs, the author computes the averages for: the turnover growth rate from first and the maximum turnover; the years between these two values; and the years in which SCs are active. Moreover, the author verifies if SCs are similar in terms of turnover by studying the relationship between the turnover growth rate and the first turnover and the reduction of turnover standard deviations.

Findings
SCs growth is very high and they reach, on average, their peak in less than three years; SCs are active, on average, for about four years; eventually, SCs exhibit a convergence process in turnover levels.

Originality/value
To the best of the author’s knowledge, there are no studies that analyse the SC turnover.
The study on the impact of environmental regulation on ecological innovation: considering the joint action of internal and external factors
Authors: Zhao Shuliang , Liu Li 
Published: June 2024

Purpose
The impact of environmental regulations on ecological innovation is a contested issue in current research. However, there is no uniform consensus on existing conclusions. It is commonly accepted among scholars that external environment and organizational characteristics are key factors affecting ecological innovation. However, these are often analyzed in isolation, without consideration of the interaction between leadership and external environment. So this study aims to explore the impact of environmental regulation on ecological innovation by combining internal and external factors.

Design/methodology/approach
Based on institutional theory and leadership theory, this paper takes environmental regulation as the independent variable, environmental leadership as the intermediary variable and intellectual property protection level as the regulating variable to explore the impact mechanism of environmental regulation on ecological innovation.

Findings
The findings indicate an inverted U-shaped relationship between environmental regulation and ecological innovation. Additionally, there is a positive correlation between environmental leadership and intellectual property protection level with ecological innovation. Furthermore, environmental leadership partially mediates the relationship between environmental regulation and ecological innovation. However, the level of intellectual property protection does not have a significant moderating effect on the relationship between environmental leadership and ecological innovation.

Originality/value
This paper proposes suggestions for regional ecological innovation based on the current policy and research situation to promote its development.
A conceptual framework for measuring and improving the resilience of biosecurity systems
Authors: Arndt Edith , Schneider Karen , Bland Lucie , Robinson Andrew , Gibert Anaïs , Camac James , Kompas Tom 
Published: June 2024

Abstract

Resilient systems can absorb and recover from disturbances and adapt to changed conditions to maintain system functionality. Uncertainty about the meaning of resilience and the attributes it requires has limited the application of resilience thinking in biosecurity. However, considering increasing pressures from trade, travel and climate change, enhancing the resilience of biosecurity systems is likely to be critical to reduce the impacts of pests and diseases on economies, societies and environments.

Here we provide a pathway for resilience thinking into risk management. Based on a literature review we discuss its benefits, develop an operational definition of resilience for biosecurity systems and identify the fundamental attributes that support resilience.

We show that resilient biosecurity systems can anticipate disturbances, cope with low‐probability high‐impact events and adapt to new and changing circumstances. The status of biosecurity system resilience can be measured using evaluative rubrics, which give decision‐makers an overall performance rating and insight into system weaknesses. General measures, objective functions and simulation approaches are potential avenues for quantifying biosecurity system resilience in practice.

Policy implications: Adopting resilience thinking into biosecurity risk management has the potential to reduce the damages caused by invading pests and diseases. If resilience thinking is used alongside traditional risk analysis, then regulators can more effectively address and prepare for the systemic consequences of high‐impact incursions and outbreaks of pests and diseases, which are unpredictable, low‐probability events. However, the design of resilience‐enhancing measures should be guided by economic principles and consider the rate of return of these measures over time.
Multimammate rat (Mastomys erythroleucus) capture‐mark‐recapture data in Bandia (Senegal) between 1984 and 2012
Authors: Granjon Laurent , Bâ Khalilou , Niang Youssoupha , Papillon Yves , Duplantier Jean‐Marc 
Published: June 2024

AbstractLong‐term ecological data are of paramount importance to document the effects of global changes on biodiversity and dynamics of populations and communities. The site of Bandia, 70 km southeast of Dakar in western Senegal, has been the scene of numerous ecological studies since the 1970s. In the frame of projects led by researchers of the Institut de Recherche pour le Développement (IRD), rodent populations were monitored at various periods using capture‐mark‐recapture (CMR) protocols on trapping grids that yielded important datasets on population dynamics and ecology of the main species present. Among them, the Guinea Multimammate Rat Mastomys erythroleucus proved to represent the dominant species. Thus, CMR data were collected on M. erythroleucus between (i) November 1975–March 1981, (ii) January 1983–October 1986, (iii) January 1997–April 2001, and (iv) June 2007–June 2012. Raw data from the 1975–1981 period were not available, but those from the three other periods are now in the IRD data repository DataSuds at https://doi.org/10.23708/YEA5AR. They represent 2556 (re)captures of 1296 M. erythroleucus individuals. They include the identity of each animal captured with some biological attributes (sex, weight at first capture, and reproductive activity), exact date and point of capture (via a trap‐specific code) at each trapping occasion, and additional comments that may help to interpret the data. This dataset concerning one of the most widespread rodent species of the Sahelo‐Sudanian bioclimatic belt provides information that can be used to address various questions such as outbreak prediction or effects of climate change. The complete data set for this abstract published in the Data Article section of the journal is also available in electronic format in MetaCat in JaLTER at http://db.cger.nies.go.jp/JaLTER/metacat/metacat/ERDP-2024-05.1/jalter-en.
Bidirectional associations between perinatal allopregnanolone and depression severity with postpartum gray matter volume in adult women
Authors: Hare Megan M. , Barber Anita , Shaffer Scott A. , Deligiannidis Kristina M. 
Published: June 2024

AbstractBackgroundPerinatal depression (PND) is a debilitating condition affecting maternal well‐being and child development. Allopregnanolone (ALLO) is important to perinatal neuroplasticity, however its relationship with depression severity and postpartum structural brain volume is unknown.MethodWe examined perinatal temporal dynamics and bidirectional associations between ALLO and depression severity and the association between these variables and postpartum gray matter volume, using a random intercept cross‐lagged panel model.ResultsWe identified a unidirectional predictive relationship between PND severity and ALLO concentration, suggesting greater depression severity early in the perinatal period may contribute to subsequent changes in ALLO concentration (β = 0.26, p = 0.009), while variations in ALLO levels during the perinatal period influences the development and severity of depressive symptoms later in the postpartum period (β = 0.38, p = 0.007). Antepartum depression severity (Visit 2, β = 0.35, p = 0.004), ALLO concentration (Visit 2, β = 0.37, p = 0.001), and postpartum depression severity (Visit 3, β = 0.39, p = 0.031), each predicted the right anterior cingulate volume. Antepartum ALLO concentration (Visit 2, β = 0.29, p = 0.001) predicted left suborbital sulcus volume. Antepartum depression severity (Visit 1, β = 0.39, p = 0.006 and Visit 2, β = 0.48, p < 0.001) predicted the right straight gyrus volume. Postpartum depression severity (Visit 3, β = 0.36, p = 0.001) predicted left middle‐posterior cingulate volume.ConclusionThese results provide the first evidence of bidirectional associations between perinatal ALLO and depression severity with postpartum gray matter volume.
The impact of high‐IgE levels on metabolome and microbiome in experimental allergic enteritis
Authors: Zubeldia‐Varela Elisa , Blanco‐Pérez Frank , Barker‐Tejeda Tomás Clive , Rojo David , Villaseñor Alma , Islam Jahidul , Gonzalez‐Menendez Irene , Laiño Jonathan , Krause Maren , Steigerwald Hanna , Martella Manuela , Quintanilla‐Martinez Leticia , Yu Philipp , Barbas Coral , Vieths Stefan , Nochi Tomonori , Barber Domingo , Toda Masako , Pérez‐Gordo Marina 
Published: June 2024

AbstractBackgroundThe pathological mechanism of the gastrointestinal forms of food allergies is less understood in comparison to other clinical phenotypes, such as asthma and anaphylaxis Importantly, high‐IgE levels are a poor prognostic factor in gastrointestinal allergies.MethodsThis study investigated how high‐IgE levels influence the development of intestinal inflammation and the metabolome in allergic enteritis (AE), using IgE knock‐in (IgEki) mice expressing high levels of IgE. In addition, correlation of the altered metabolome with gut microbiome was analysed.ResultsOvalbumin‐sensitized and egg‐white diet‐fed (OVA/EW) BALB/c WT mice developed moderate AE, whereas OVA/EW IgEki mice induced more aggravated intestinal inflammation with enhanced eosinophil accumulation. Untargeted metabolomics detected the increased levels of N‐tau‐methylhistamine and 2,3‐butanediol, and reduced levels of butyric acid in faeces and/or sera of OVA/EW IgEki mice, which was accompanied with reduced Clostridium and increased Lactobacillus at the genus level. Non‐sensitized and egg‐white diet‐fed (NC/EW) WT mice did not exhibit any signs of AE, whereas NC/EW IgEki mice developed marginal degrees of AE. Compared to NC/EW WT mice, enhanced levels of lysophospholipids, sphinganine and sphingosine were detected in serum and faecal samples of NC/EW IgEki mice. In addition, several associations of altered metabolome with gut microbiome—for example Akkermansia with lysophosphatidylserine—were detected.ConclusionsOur results suggest that high‐IgE levels alter intestinal and systemic levels of endogenous and microbiota‐associated metabolites in experimental AE. This study contributes to deepening the knowledge of molecular mechanisms for the development of AE and provides clues to advance diagnostic and therapeutic strategies of allergic diseases.