bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aesthetic Changes of Edentulous Patients Before and After Full-arch Implant Restoration by 3D Facial Scanning
Authors: Ma Hongyang , Wu Yuwei , Cao Jia , Han Yu , Deng Xuliang , Tang Zhihui 
Published: June 2024

Abstract

Background:
Edentulous patients often experience psychological occlusal fatigue, dysphonia and facial deformity which severely decreased quality of life. Recovery of facial aesthetic is one of important concerns of dentulous patients, however, traditional two-dimensional pictures are not enough to accurately evaluate the three-dimensional changes in patients after full-arch implant restoration. Facial scanning technology, a cutting-edge validation method for facial transformation evaluation device, makes it possible to realize high-precision facial scanning and measuring.
Methods:
Edentulous patients were prospectively enrolled in this study. Preoperative and postoperative Cone beam Computed Tomography (CBCT) and intra-oral scans were obtained for each patient. The CBCT and intra-oral images were then imported into the three dimensional (3D) facial scanner, where they were reconstructed into three-dimensional models for evaluation.
Results:
A total of 10 patients were included in this study. All edentulous patients underwent three-dimensional facial scanning before and after implant restoration and were evaluated for facial aesthetic parameters. The mean age of the patients was 64.9 ± 11.4 years (range, 38–78 years), and the mean follow-up time was 12 months (range, 3–24 months). All patients had satisfactory outcomes without major complications. This method accurately validates the postoperative facial transformation in all patients. All measured aesthetic parameters suggest that the patient received a very favorable improvement in the contour of the face.
Conclusions:
By a high precision scanner that oral implant restorations can effectively improve the convexity of the lower third of the face and lips in edentulous jaw patients, thus realizing an improvement in facial aesthetics.
Adherence to Iron-Folic Acid Supplementation and Associated Factors Among Pregnant Women Attending Antenatal Clinic In Shashemene town Health Facility, Southeast Ethiopia,2024; Facility based cross-sectional Study
Authors: washo Assefa , Tsegaye Ashenafi 
Published: June 2024

Abstract

Background; Pregnant women are at a high risk of anemia, with iron-folate deficiency being the most common cause of anemia among pregnant women. Despite the well-known importance of iron and folic acid supplementation (IFAS) during pregnancy, adherence to these supplements is relatively low and associated factors were not well identified in the study area. The aim of this study was to assess Iron - Folic Acid Supplementation adherence and Associated Factors among Pregnant Women Attending Antenatal Clinic in Shashemene town public health facilities, Southeast Ethiopia; 2024. Method Facility-based cross-sectional study design was employed selecting 415 pregnant women attending antenatal care services in four public health institutions of Shashemene town. Health facility were selected by simple random sampling using lottery method. Based on quarterly report of population size, proportion to sample size allocation made at each selected health facilities. Finally, pregnant women who visited for Antenatal care service at selected health facilities during data collection period were consecutively included in the study. Data were collected by interview. Then it was entered into EPI Data version 3.1 and exported to SPSS version 27 for analysis. Bivariate and multivariate binary logistic regression techniques were used to identify independent predictors. A p-value < 0.05 was taken as indication of statistical significance Results The overall adherence status of pregnant women attending antenatal clinic was found to be 66.5%. Participating on pregnant mother conference (AOR = 5.39, 95%CI: 3.29–8.83), having less than four children (AOR = 1.88, 95% CI (1.12, 3.13) and good knowledge of IFAS (AOR = 2.61, 95% CI (1.51, 4.53), were statistically and positively associated with pregnant mothers adherence to iron and folic acid supplementation. Conclusions The study revealed a notably high adherence to iron-folic acid (IFA) supplementation among the women included, surpassing rates observed in both national and international studies. Factors contributing to this included receiving information and education on IFA supplementation during pregnant mother conferences conducted by health professionals, possessing knowledge about IFAS, and having fewer than or equal to four children. Intervention strategies targeting these factors are strongly recommended to sustain and potentially increase mothers' adherence to IFA supplementation.
Ecosystem transformation upon Aptian seawater ingress into the Proto-South Atlantic Ocean
Authors: Ma Jian , Cury Leonardo , Rumbelsperger Anelize , Albrecht Heidi , Adams Erwin , Amthor Joachim , Cui Xingqian , Cremiere Antoine , Sato Kei , Bergmann Kristin , Summons Roger 
Published: June 2024

Abstract

The early evolution of the South Atlantic Ocean following the Cretaceous break-up of Gondwana is extensively recorded in rift basins along the conjugate margins of Africa and Brazil. For the Brazil margin, divergent views of the source and pathway of the initial seawater incursion persist due to a paucity of recognized transitional sequences that document marine transgressive deposits over the continental interior. To address this, we conducted a high-resolution sedimentological and geochemical study through a core in the Campos Basin that encompasses the key lithologic switch from lacustrine carbonate to marine evaporite settings. Steroid lipid biomarkers, derived from marine algae, make a striking appearance in concert with a pronounced negative shift of 87Sr/86Sr ratios and coincident with the appearance of anhydrite. Importantly, the sulfur-sequestered biomarkers reveal a dynamic system where redox-stratified and anoxic conditions were amplified along with a deepening chemocline through the marine transition.
Prediction of early postoperative functional outcomes in patients with aneurysmal subarachnoid hemorrhage: a Chinese bicenter retrospective study
Authors: Chu Liang , Qi Ming , Ding Yingying , Jiang Kuan , Lu Yunpeng , Cao Kan , Wu Da 
Published: June 2024

Abstract

Objectives
This study aims to analyze the early functional outcomes of patients with aneurysmal subarachnoid hemorrhage (aSAH) undergoing endovascular coiling or surgical clipping, and to construct predictive models based on both treatment modalities.
Materials and Methods
Patients diagnosed with aSAH were recruited from two Chinese hospitals between 1st January ,2015 and 31st December,2022. These patients were categorized into two groups: the endovascular coiling group and the surgical clipping group. Independent risk factors were determined using Least Absolute Shrinkage and Selection Operator regression and multivariate logistic regression. The relative weights of these significant factors were computed, and nomograms were developed accordingly. Subsequent validation analyses were conducted to assess the performance of the nomograms.
Results
Multifactorial analyses revealed that Hunt-Hess grade, GCS score, mFS, D-dimer, age, and body temperature can predict early functional outcomes of endovascular coiling (all P values < 0.05), while Hunt-Hess grade, GCS score, mFS, and D-dimer can predict early functional outcomes of surgical clipping (all P values < 0.05). Further computation of weights showed that the contributions of Hunt-Hess grade, mFS, GCS score and D-dimer were 32.78%, 31.99%, 4.63% and 13.73%, respectively, for endovascular coiling, and 33.55%, 38.02%, 8.44% and 19.99% for surgical clipping. Nomograms were constructed for the endovascular coiling and surgical clipping groups, and their discriminative ability and clinical utility were validated using ROC curves, calibration curves, and DCA curves, demonstrating good performance.
Conclusion
This study developed predictive nomogram models for early functional outcomes of patients with aSAH undergoing endovascular coiling or surgical clipping. It underscores the significance of scoring systems and clinical parameters (such as D-dimer), showing strong clinical utility.
Enhancing the Validity of the SARC-CalF Questionnaire with a Sit-to-Stand Question for Sarcopenia Screening
Authors: Kingpetch Kanaungnit , Mungcharoenporm Isaya 
Published: June 2024

Abstract

The SARC-CalF questionnaire is a screening tool for sarcopenia, but its sensitivity remains limited. To enhance the sensitivity of this questionnaire for sarcopenia screening, we modified it by incorporating a question about the 5-time sit-to-stand test and renamed it the "SARC-CalF-STS questionnaire". This study aimed to evaluate the diagnostic validity of the SARC-CalF-STS questionnaire for screening sarcopenia among elderly individuals. The SARC-CalF-STS questionnaire was tested on outpatients aged ≥ 60 years who had visited at our hospital. Sarcopenia diagnosis was established by measuring the appendicular skeletal muscle mass index (ASM) using Dual Energy X-ray Absorptiometry (DXA) scans and handgrip strength. Diagnoses were based on the Asian Working Group for Sarcopenia (AWGS) 2019 criteria. The study included 170 participants with a mean age of 68.8 ± 6.4 years. The prevalence of sarcopenia was found to be 20.59%. The SARC-CalF-STS questionnaire demonstrated a sensitivity of 77.1%, specificity of 54.1%, positive predictive value of 30.3%, and negative predictive value of 90.1%. The SARC-CalF-STS questionnaire displayed relatively high sensitivity, suggesting that it may serve as a potentially valuable initial screening tool for sarcopenia, especially among elderly female populations.
Construction of an Aspergillus oryzae △nptB△pyrG host for homologous expression of Aspergillus oryzae lipase and catalytic properties characterization of recombinant lipase
Authors: Zhang Yueting , Nie Hongmei , Zhang Fei , Jin Mengmeng , Wang Zhao , zheng jianyong 
Published: June 2024

Abstract

Aspergillus oryzae is an ideal cell factory for protein expression with powerful protein processing and secretion capabilities, and is suitable for expression of fungus-derived proteins. The current study aimed to explore the homologous expression of A. oryzae lipase AOL (GenBank: KP975533) by constructing an auxotrophic A. oryzae △pyrG△nptB, and subsequently characterizing the immobilization and catalytic properties of recombinant lipase. Initially, the pyrG gene knocked out in wild-type A. oryzae by homologous recombination of the transformed linearized fragments, followed by the creation of a uridine/uracil auxotroph transformation. Through this system, the protease gene nptB was precisely knocked out, leading to a substantial decrease in extracellular (39.04%) and intracellular (90.07%) protease activity. The A. oryzae △nptB△pyrG strain was used as host for homologous expression of lipase AOL. The engineered A. oryzae AOL-8 was screened out, which exhibiting extracellular and intracellular lipase activities of 1.75 U/mL and 46.4 U/g, respectively. Quantitative PCR analysis revealed that the lipase gene copy number in the engineered strain AOL-8 was 14. Subsequently, the production and immobilization of the recombinant lipase, via physical adsorption on macroporous resin, was achieved through submerged fermentation of the AOL-8 strain. The esterification catalytic properties of recombinant lipase with carboxylic acid and short-chain alcohols were characterized. The results indicated that the lipase exhibited optimal catalytic activity with lauric acid and methanol as substrates, a reaction temperature of 35°C, and n-hexane as the preferred solvent medium.
Protocol for a Study Investigating Context-Specific Sedentary Behaviors and Cardiometabolic Health in College-Based Young Adults (CONTEXT-SB)
Authors: Diana Jake C. , Chauntry Aiden J. , Cowley Emma , Paterson Craig , Struder Jeb , Pagan-Lasalle Patricia , Meyer Michelle L. , Lin Feng-Chang , Moore Justin B. , Hanson Erik D. , Stoner Lee 
Published: June 2024

Abstract

Background
Sedentary behavior (SB) is detrimental to cardiometabolic disease (CMD) risk, which can begin in young adulthood. To devise effective SB-CMD interventions in young adults, it is important to understand which context-specific sedentary behaviors (CS-SB) are most detrimental for CMD risk, the lifestyle behaviors that co-exist with CS-SBs, and the socioecological predictors of CS-SB.
Methods
This longitudinal observational study will recruit 500 college-aged (18–24 years) individuals. Two laboratory visits will occur, spaced 12 months apart, where a composite CMD risk score (e.g., arterial stiffness, metabolic and inflammatory biomarkers, heart rate variability, and body composition) will be calculated, and questionnaires to measure lifestyle behaviors and different levels of the socioecological model will be administered. After each visit, total SB (activPAL) and CS-SB (television, transportation, academic/ occupational, leisure computer, “other”; ecological momentary assessment) will be measured across seven days.
Discussion
It is hypothesized that certain CS-SB will show stronger associations with CMD risk, compared to T-SB, even after accounting for coexisting lifestyle behaviors. It is expected that a range of intra-individual, inter-individual, and physical environment socioecological factors will predict CS-SB. The findings from this study will support the development of an evidence-based, multi-level intervention to target SB reduction and mitigate CMD risk in CBYA.
Mitigating COVID-19-Related Depression: A Meta-Analysis of Cognitive Behavioral Therapy Efficacy with Subgroup Analysis
Authors: Jumadi Jumadi , Puspita Kartika , Anasanti Mila Desi 
Published: June 2024

Abstract

Background
Amidst the global prevalence of COVID-19, depression has emerged as a leading mental health concern, underscoring the urgent need to address psychological distress during this public health crisis. Despite its widespread impact, there is a notable dearth of research focusing on interventions tailored specifically for COVID-19 patients.
Objective
Against the backdrop of the COVID-19 pandemic's profound effect on mental health, particularly concerning depression, this study aims to evaluate the efficacy of cognitive behavioral therapy (CBT) in mitigating psychological distress among individuals affected by COVID-19.
Method
A comprehensive literature search was conducted across multiple databases, including PubMed, Google Scholar, ScienceDirect, Crossref, and Web of Science, adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology. Randomized controlled trials (RCTs) meeting the inclusion criteria were selected for analysis. Cochrane's Risk of Bias (RoB) tool was utilized to ensure rigorous evaluation. Subgroup meta-analysis was employed to explore variations in treatment effects among different demographic or clinical subgroups, including factors such as country of origin, age groups, duration of therapy sessions, and baseline assessment scores. A random-effects model was utilized to assess the standard deviation from the mean (SMD) and its associated p-value for meta-analysis.
Results
A total of 30 RCTs were included in the analysis, comprising 12,428 depression patients during the COVID-19 pandemic. Subgroup analysis revealed significant variations across countries. Despite differences, all studies demonstrated low bias risk. The forest plot indicated a significant reduction in depression scores post-CBT intervention (p = 0.0002, SMD: 1.27, 95% CI: 0.61; 1.93). Subgroup analyses based on therapy duration and assessment methods showed consistent reductions in depression scores across different lengths of therapy and assessment tools: 6-week (SMD: -0.09 [-0.32; 0.14]), 8-week (SMD: -0.26 [-0.74; 0.22]), 1-week (SMD: -0.09 [-0.21; 0.03]), 2-week (SMD: 0.04 [-0.11; 0.19]), and 12-week (SMD: -0.14 [-0.27; -0.01]). These results highlight CBT's efficacy in managing COVID-19-related depression.
Conclusions
CBT significantly reduces depression scores among individuals with COVID-19-related depression, highlighting its effectiveness across diverse populations and treatment durations.
Extracorporeal membrane oxygenation in Trauma: A single-center review
Authors: Ahlqvist Mathias , Forsman Pär , Morberg Pål , Larsson Magnus , Broman Lars Mikael , Akram Shahzad 
Published: June 2024

Abstract

Purpose
Globally, trauma is a leading cause of death in young adults. The use of extracorporeal membrane oxygenation (ECMO) in the trauma population remains controversial due to the limited published research. This study aimed to analyze 30-day survival of all the trauma ECMO patients at our center, with respect to injury severity score (ISS), new injury severity score (NISS).
Methods
We performed a retrospective analysis of all trauma patients receiving ECMO support at a Level 1 trauma center in Sweden between 1997 and 2019.
Results
A total of 53 trauma patients received ECMO support. Eighty-five percent were male; the median age was 24, with interquartile range (IQR) 17–44 years. More than 70% were multi-trauma patients. The mean NISS and ISS were 50 (IQR:34–57) and 42 (IQR:33–57), respectively. Sixty-two percent were supported on veno-arterial ECMO with a survival benefit for veno-venous ECMO (75% vs. 36%, respectively (p = 0.01)). There was no association between severity in terms of trauma-score and survival. Sixteen patients (30%) were cannulated at referring hospitals and transported to our unit on ECMO with a survival of 69%, similar to those cannulated in-house. Sixty percent of patients survived ECMO, and 51% survived to hospital discharge.
Conclusions
This study indicates that trauma patients benefit from ECMO, independent of severity. Furthermore, our results support ECMO transport as feasible in trauma patients. We recommend larger multi-center studies to determine which trauma patients would have the greatest benefit of ECMO.
Animal pollination contributes to more than half of Citrus production
Authors: MONASTEROLO MARCOS , Ramírez-Mejía Andrés Felipe , Cavigliasso Pablo , Schliserman Pablo , Chavanne Valentina , Carro Claudia Melissa , Chacoff Natacha Paola 
Published: June 2024

Abstract

Animal pollination is crucial for the reproduction and economic viability of a wide range of crops. Despite the existing data, the extent to which citrus crops depend on pollinators to guarantee fruit production still needs to be determined. Here, we described the composition of flower visitors in citrus (Citrus spp.) from the main growing areas of Argentina; moreover, we combined Bayesian models and empirical simulations to assess the contribution of animal pollination on fruit set and yield ha− 1 in different species and cultivars of lemon, grapefruit, mandarin, and orange in the same regions. Honeybee (A. mellifera L.) was the most commonly observed visitor, followed by a diverse group of insects, mainly native bees. Regardless of citrus species and cultivars, the probability of flowers setting fruit in pollinated flowers was 2.4 times higher than unpollinated flowers. Furthermore, our simulations showed that about 60% of the citrus yield ha− 1 can be attributable to animal pollination across all species and cultivars. Therefore, it is crucial to maintain environments that support pollinator diversity and increase consumer and to producer awareness and demand in order to ensure the significant benefits of animal pollination in citrus production.
Psoriasis and Pulmonary Function - Unveiling Genetic Connections
Authors: Tanimura Kazuya , Aldrich Melinda , Jaworski James , Xing Jinchuan , Okawa Satoshi , Chandra Divay , Nouraie Seyed , Nyunoya Toru 
Published: June 2024

Abstract

Psoriasis, an immune-mediated skin disease characterized by erythematous plaques, is often associated with chronic lung diseases that impair pulmonary function. To investigate a potential genetic link between psoriasis and pulmonary function, we analyzed 63 previously reported psoriasis-associated single nucleotide polymorphisms (SNPs) for their associations with both psoriasis and pulmonary function measurements using data from the UK Biobank (UKBB) and Vanderbilt University Medical Center Biobank (BioVU). Our results confirm significant associations of specific SNPs with both the risk of psoriasis and changes in pulmonary function. Notably, the minor alleles of rs17716942 and rs8016947 were linked to a lower risk of psoriasis and improved pulmonary function across both biobank cohorts. These findings highlight potential genetic intersections involving immune regulation and inflammatory responses, mediated by genes such as IFIH1, GCA, and NFKBIA, which may underlie the observed "skin-lung axis" in psoriatic patients.
5-Fluorouracil plus L-leucovorin and oxaliplatin treatment for esophageal squamous cell carcinoma: A multicenter retrospective study
Authors: Shiraishi Kazuhiro , Okada Mao , Yamamoto Shun , Matsubara Yuki , Masuishi Toshiki , Shimozaki Keitaro , Yamamoto Yoshiyuki , Hirose Suguru , Sugiyama Keiji , Furuta Mitsuhiro , Machida Nozomu , Takahashi Naoki , Yoshii Takako , Kito Yosuke , Tsuzuki Takao , Boku Shogen , Tsuchihashi Kenji , Akinori Sugaya , Takayama Toshizo , Komori Azusa , Mitani Seiichiro , Matsumoto Toshihiko , Hirata Kenro , Nishimura Takashi 
Published: June 2024

Abstract

Background
Cisplatin-based chemotherapy is the standard treatment for advanced esophageal squamous cell carcinoma (ESCC). However, the 5-fluorouracil plus L-leucovorin and oxaliplatin (FOLFOX) regimen is available in Japan as an alternative to cisplatin-based chemotherapy, but its efficacy and safety remain unclear. Hence, we aimed to retrospectively evaluate patients with advanced ESCC who received FOLFOX therapy.
Methods
Patients with advanced ESCC who received FOLFOX therapy at 18 institutions between April 2019 and October 2020 were included. Fifty-two patients were received first-line FOLFOX treatment, while 39 patients received later-line FOLFOX treatment.
Results
The median progression-free survival, median overall survival, and objective response rate were 3.8 months (95% confidence interval [CI]: 3.0–5.0), 13.9 months (95% CI: 10.3–17.9 months), and 35% in the first-line group and 2.4 months (95% CI: 2.1–3.8 months), 7.2 months (95% CI: 5.3–9.8 months), and 4% in the later-line group, respectively. The most frequent grade 3 or 4 adverse events were neutropenia (23%) and anemia (12%) in the first-line group and neutropenia (18%), anorexia (13%), anemia (10%), and nausea (10%) in the later-line group.
Conclusion
First-line FOLFOX treatment is suitable for patients with advanced ESCC. However, FOLFOX has shown limited efficacy as a later-line treatment.