bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of p53 mutation in the effect of boron neutron capture therapy on oral squamous cell carcinoma
Authors: Fujita Yusei , Kato Itsuro , Iwai Soichi , Ono Koji , Suzuki Minoru , Sakurai Yoshinori , Ohnishi Ken , Ohnishi Takeo , Yura Yoshiaki 
Published: December 2009

Abstract

Background
Boron neutron capture therapy (BNCT) is a selective radiotherapy, being effective for the treatment of even advanced malignancies in head and neck regions as well as brain tumors and skin melanomas. To clarify the role of p53 gene, the effect of BNCT on oral squamous cell carcinoma (SCC) cells showing either wild- (SAS/neo) or mutant-type (SAS/mp53) p53 was examined.

Methods
Cells were exposed to neutron beams in the presence of boronophenylalanine (BPA) at Kyoto University Research Reactor. Treated cells were monitored for modulations in colony formation, proliferation, cell cycle, and expression of cell cycle-associated proteins.

Results
When SAS/neo and SAS/mp53 cells were subjected to BNCT, more suppressive effects on colony formation and cell viability were observed in SAS/neo compared with SAS/mp53 cells. Cell cycle arrest at the G1 checkpoint was observed in SAS/neo, but not in SAS/mp53. Apoptotic cells increased from 6 h after BNCT in SAS/neo and 48 h in SAS/mp53 cells. The expression of p21 was induced in SAS/neo only, but G2 arrest-associated proteins including Wee1, cdc2, and cyclin B1 were altered in both cell lines.

Conclusion
These results indicate that oral SCC cells with mutant-type are more resistant to BNCT than those with wild-type p53, and that the lack of G1 arrest and related apoptosis may contribute to the resistance. At a physical dose affecting the cell cycle, BNCT inhibits oral SCC cells in p53-dependent and -independent manners.
Lanthanum associated abnormal liver function tests in two patients on dialysis: a case report
Authors: Namagondlu Girish , Main Norman , Yates Lucy , Mooney Joanne , Sathyamurthy Sangita , Daryanani Indiver , Crowe Alex , Ledson Tom , Banerjee Anindya 
Published: December 2009

Abstract
Lanthanum (La) is a phosphate binder used in patients on dialysis in the UK. As it has only recently been in use, there are no long-term data about safety of this rare metal in human subjects with renal failure on renal replacement therapy. La has not been previously reported to cause any adverse reactions apart from nausea, sickness, dialysis graft occlusion and abdominal pain. We report here La induced abnormal liver function tests in a male and a female patient of 70 and 44 years old each, on peritoneal dialysis (PD) and haemodialysis (HD) respectively, the first report of such an adverse reaction to this agent.
Silicone migration to the contralateral axillary lymph nodes and breast after highly cohesive silicone gel implant failure: a case report
Authors: Kaufman Gabriel J , Sakr Rita A , Inguenault Cyrille , Sarfati Isabelle , Nos Claude , Clough Krishna B 
Published: December 2009

Abstract
Highly cohesive silicone gel implants are advertised for aesthetic and safety advantages. Our case is the fourth report describing early implant rupture and contralateral migration of siliconoma. Despite the greater degree of gel cohesiveness, a continued vigilance for signs and symptoms of migration is highly recommended.
Chronic slowly progressive monoarthritis tuberculosis of the hip without systemic symptoms mimicking osteoarthritis: a case report
Authors: Ramos Carina Guedes , Alves Marcelle Duarte , Santos Rodrigo Pires dos , Falci Diego , Goldani Luciano Zubaran 
Published: December 2009

Abstract
The authors report and discuss the clinical and radiological features of a immunocompetent patient with chronic progressive monoarthritis tuberculosis of the hip without systemic symptoms such as fever, and weight loss presenting as caseating abscess and severe destruction of the hip joint, treated with resection arthroplasty.
A welder with pneumosiderosis: a case report
Authors: Khalid Imran , Khalid Tabindeh J , Jennings Jeffrey H 
Published: December 2009

Abstract
Pneumosiderosis or Welder's lung is an occupational lung disease which is usually seen after chronic exposure to iron dust. We present a case of a 64-year-old welder in whom the diagnosis of pneumosiderosis was made by lung biopsies. We also briefly review the literature regarding the disease, its prognosis and association with development of lung cancer. Avoidance of iron dust exposure and implementing prevention strategies in people at risk are the mainstay of therapy.
Predictors of the first cardiovascular event in patients with systemic lupus erythematosus - a prospective cohort study
Authors: Gustafsson Johanna , Gunnarsson Iva , Börjesson Ola , Pettersson Susanne , Möller Sonia , Fei Guo-Zhong , Elvin Kerstin , Simard Julia F , Hansson Lars-Olof , Lundberg Ingrid E , Larsson Anders , Svenungsson Elisabet 
Published: December 2009

Abstract
Introduction
Cardiovascular disease (CVD) is a major cause of premature mortality among Systemic lupus erythematosus (SLE) patients. Many studies have measured and evaluated risk factors for premature subclinical atherosclerosis, but few studies are prospective and few have evaluated risk factors for hard endpoints, i.e. clinically important cardiovascular events (CVE). We investigated the impact of traditional and lupus associated risk factors for the first ever CVE in a longitudinal cohort of SLE patients.

Methods
A total of 182 SLE patients (mean age 43.9 years) selected to be free of CVE were included. Cardiovascular and autoimmune biomarkers were measured on samples collected after overnight fasting at baseline. Clinical information was collected at baseline and at follow up. End point was the first ever CVE (ischemic heart, cerebrovascular or peripheral vascular disease or death due to CVD). Impact of baseline characteristics/biomarkers on the risk of having a first CVE was evaluated with Cox regression.

Results
Follow up was 99.5% after a mean time of 8.3 years. Twenty-four patients (13%) had a first CVE. In age-adjusted Cox regression, any positive antiphospholipid antibody (aPL), elevated markers of endothelial activation (von Willebrand factor (vWf), soluble vascular cellular adhesion molecule-1 (sVCAM-1)) and fibrinogen predicted CVEs. Of SLE manifestations, arthritis, pleuritis and previous venous occlusion were positively associated with future CVEs while thrombocytopenia was negatively associated. Among traditional risk factors only age and smoking were significant predictors. In a multivariable Cox regression model age, any positive aPL, vWf and absence of thrombocytopenia were all predictors of the first CVE.

Conclusions
In addition to age, positive aPL, biomarkers indicating increased endothelial cell activity/damage, and absence of thrombocytopenia were independent predictors of CVEs in this prospective study. Our results indicate that activation of the endothelium and the coagulation system are important features in SLE related CVD. Furthermore, we observed that the risk of CVEs seems to differ between subgroups of SLE patients.
Intensive insulin treatment improves forearm blood flow in critically ill patients: a randomized parallel design clinical trial
Authors: Žuran Ivan , Poredoš Pavel , Skale Rafael , Voga Gorazd , Gabršček Lucija , Parežnik Roman 
Published: December 2009

Abstract
Introduction
Intensive insulin treatment of critically ill patients was seen as a promising method of treatment, though recent studies showed that reducing the blood glucose level below 6 mmol/l had a detrimental outcome. The mechanisms of the effects of insulin in the critically ill are not completely understood. The purpose of the study was to test the hypothesis that intensive insulin treatment may influence forearm blood flow independently of global hemodynamic indicators.

Methods
The study encompassed 29 patients of both sexes who were admitted to the intensive care unit due to sepsis and required artificial ventilation as the result of acute respiratory failure. 14 patients were randomly selected for intensive insulin treatment (Group 1; blood glucose concentration 4.4-6.1 mmol/l), and 15 were selected for conventional insulin treatment (Group 2; blood glucose level 7.0 mmol/l-11.0 mmol/l). At the start of the study (t0, beginning up to 48 hours after admittance and the commencement of artificial ventilation), at 2 hours (t1), 24 hours (t2), and 72 hours (t3) flow in the forearm was measured for 60 minutes using the strain-gauge plethysmography method. Student's t-test of independent samples was used for comparisons between the two groups, and Mann-Whitney's U-test where appropriate. Linear regression analysis and the Pearson correlation coefficient were used to determine the levels of correlation.

Results
The difference in 60-minute forearm flow at the start of the study (t0) was not statistically significant between groups, while at t2 and t3 significantly higher values were recorded in Group 1 (t2; Group 1: 420.6 ± 188.8 ml/100 ml tissue; Group 2: 266.1 ± 122.2 ml/100 ml tissue (95% CI 30.9-278.0, P = 0.02); t3; Group 1: 369.9 ± 150.3 ml/100 ml tissue; Group 2: 272.6 ± 85.7 ml/100 ml tissue (95% CI 5.4-190.0, P = 0.04). At t1 a trend towards significantly higher values in Group 1 was noted (P = 0.05). The level of forearm flow was related to the amount of insulin infusion (r = 0.40).

Conclusions
Compared to standard treatment, intensive insulin treatment of critically ill patients increases forearm flow. Flow increase was weakly related to the insulin dose, though not to blood glucose concentration.

Trial Registration
Trial number: ISRCTN39026810.
Pressure-dependent stress relaxation in acute respiratory distress syndrome and healthy lungs: an investigation based on a viscoelastic model
Authors: Ganzert Steven , Möller Knut , Steinmann Daniel , Schumann Stefan , Guttmann Josef 
Published: December 2009

Abstract
Introduction
Limiting the energy transfer between ventilator and lung is crucial for ventilatory strategy in acute respiratory distress syndrome (ARDS). Part of the energy is transmitted to the viscoelastic tissue components where it is stored or dissipates. In mechanically ventilated patients, viscoelasticity can be investigated by analyzing pulmonary stress relaxation. While stress relaxation processes of the lung have been intensively investigated, non-linear interrelations have not been systematically analyzed, and such analyses have been limited to small volume or pressure ranges. In this study, stress relaxation of mechanically ventilated lungs was investigated, focusing on non-linear dependence on pressure. The range of inspiratory capacity was analyzed up to a plateau pressure of 45 cmH2O.

Methods
Twenty ARDS patients and eleven patients with normal lungs under mechanical ventilation were included. Rapid flow interruptions were repetitively applied using an automated super-syringe maneuver. Viscoelastic resistance, compliance and time constant were determined by multiple regression analysis using a lumped parameter model. This same viscoelastic model was used to investigate the frequency dependence of the respiratory system's impedance.

Results
The viscoelastic time constant was independent of pressure, and it did not differ between normal and ARDS lungs. In contrast, viscoelastic resistance increased non-linearly with pressure (normal: 8.4 (7.4-11.9) [median (lower - upper quartile)] to 35.2 (25.6-39.5) cmH2O·sec/L; ARDS: 11.9 (9.2-22.1) to 73.5 (56.8-98.7)cmH2O·sec/L), and viscoelastic compliance decreased non-linearly with pressure (normal: 130.1(116.9-151.3) to 37.4(34.7-46.3) mL/cmH2O; ARDS: 125.8(80.0-211.0) to 17.1(13.8-24.7)mL/cmH2O). The pulmonary impedance increased with pressure and decreased with respiratory frequency.

Conclusions
Viscoelastic compliance and resistance are highly non-linear with respect to pressure and differ considerably between ARDS and normal lungs. None of these characteristics can be observed for the viscoelastic time constant. From our analysis of viscoelastic properties we cautiously conclude that the energy transfer from the respirator to the lung can be reduced by application of low inspiratory plateau pressures and high respiratory frequencies. This we consider to be potentially lung protective.
Altered eosinophil profile in mice with ST6Gal-1 deficiency: an additional role for ST6Gal-1 generated by the P1 promoter in regulating allergic inflammation
Authors: Nasirikenari Mehrab , Chandrasekaran E V , Matta Khushi L , Segal Brahm H , Bogner Paul N , Lugade Amit A , Thanavala Yasmin , Lee James J , Lau Joseph T Y 
Published: December 2009

Abstract
ST6Gal-1 is a participant in regulating not only Th1 but also Th2 responses; ST6Gal-1 deficiency can lead to the development of more severe allergic inflammation with excessive eosinophil production.
Cumulative evidence indicates that the sialyltransferase ST6Gal-1 and the sialyl-glycans, which it constructs, are functionally pleiotropic. Expression of the ST6Gal-1 gene is mediated by six distinct promoter/regulatory regions, and we hypothesized that these promoters may be used differentially to produce ST6Gal-1 for different biologic purposes. To examine this hypothesis, we compared a mouse with a complete deficiency in ST6Gal-1 (Siat1 null) with another mouse that we have created previously with a disruption only in the P1 promoter (Siat1ΔP1). We noted previously greater neutrophilic inflammation associated with ST6Gal-1 deficiency. Here, we report that ST6Gal-1-deficient mice also have significantly elevated eosinophilic responses. Upon i.p. thioglycollate elicitation, eosinophils accounted for over 20% of the total peritoneal inflammatory cell pool in ST6Gal-1-deficient animals, which was threefold greater than in corresponding wild-type animals. A principal feature of allergic respiratory inflammation is pulmonary eosinophilia, we evaluated the role of ST6Gal-1 in allergic lung inflammation. Using OVA and ABPA experimental models of allergic airways, we showed that ST6Gal-1 deficiency led to greater airway inflammation characterized by excessive airway eosinophilia. The severity of airway inflammation was similar between Siat1ΔP1 and Siat1 null mice, indicating a role for P1-generated ST6Gal-1 in regulating eosinophilic inflammation. Colony-forming assays suggested greater IL-5-dependent eosinophil progenitor numbers in the marrow of ST6Gal-1-deficient animals. Moreover, allergen provocation of wild-type mice led to a significant reduction in P1-mediated ST6Gal-1 mRNA and accompanied decline in circulatory ST6Gal-1 levels. Taken together, the data implicate ST6Gal-1 as a participant in regulating not only Th1 but also Th2 responses, and ST6Gal-1 deficiency can lead to the development of more severe allergic inflammation with excessive eosinophil production.
Adorno'sComment C'est
Authors: ULLYOT JONATHAN 
Published: December 2009

According to Theodor Adorno, the modern artwork makes the beholder shudder and reflect, purging his habit of over-conceptualizing. Furthermore, although the modern artwork may seem incomprehensible and foreign to the beholder, it expresses only a simple message: “this is how it is.” The artwork is not in itself an imposition, demand, or confrontation, though it may have all of these effects. Ontologically, the artwork is an expression: “It is thus.” To avoid the trap of conceptualization, Adorno varies the concept-name of this simple expression throughout Aesthetic Theory—from Sosein (or So-und-nicht-anders-Seins) to So ist es (with some other variations: for example, the “Here I am” or “This is what I am” of Etruscan vases), and finally to “Comment c'est,” which Adorno equates with “that's what it's like out there” (“so geht es zu, so ist es draussen”) as well as with “how it is” (“wie es ist”). This concept-name at times appears demonstrative—“It is thus”—at times general—“how it is”—and at times self-referential—“here I am.”Although Adorno's English translator Hullot-Kentor notes that the meaning of Sosein for Adorno is equivalent to that of Beckett's “Comment c'est,” he refers to the French phrase as though it were a theoretical concept instead of the title of a prose work by Beckett published in 1961. In this essay I attempt to rectify that oversight by demonstrating that within Adorno's Aesthetic Theory Beckett's Comment c'est functions not as an artwork but as the slippage of the concept Sosein. Comment c'est remains a “comment c'est” for Adorno—not just an exemplum, or a reference, but something between a concept-name and an actual artwork: a “title” that reveals not only its own essence but also the essence of modern art. My analysis thus moves between reading Comment c'est as, on the one hand, a literalization of Adorno's ideas in Aesthetic Theory (in other words, as a kind of meta-text) and, on the other, as an exemplum of his views on the new, on unity and meaning, and on mimesis and expression. In doing so, I hope to deepen our understanding of the special place that Beckett occupies within Adorno's philosophy.
Erlotinib resistance in mouse models of epidermal growth factor receptor-induced lung adenocarcinoma
Authors: Politi Katerina , Fan Pang-Dian , Shen Ronglai , Zakowski Maureen , Varmus Harold 
Published: December 2009

SUMMARY
Seventy-five percent of lung adenocarcinomas with epidermal growth factor receptor (EGFR) mutations respond to treatment with the tyrosine kinase inhibitors (TKIs) gefitinib and erlotinib; however, drug-resistant tumors eventually emerge. In 60% of cases, resistant tumors carry a secondary mutation in EGFR (T790M), amplification of MET, or both. Here, we describe the establishment of erlotinib resistance in lung tumors, which were induced by mutant EGFR, in transgenic mice after multiple cycles of drug treatment; we detect the T790M mutation in five out of 24 tumors or Met amplification in one out of 11 tumors in these mice. This preclinical mouse model, therefore, recapitulates the molecular changes responsible for resistance to TKIs in human tumors and holds promise for the discovery of additional mechanisms of drug resistance in lung cancer.
A DFT and CASSCF Study of Photocycloaddition Reactions of Biradicals from 6-Amino-2-(3-thienoyl)-1,4-benzoquinone
Authors: Sharma Gitanjali , Abraham Ignatious , Pardasani Ram T , Bharatam Prasad V , Mukherjee Tulsi 
Published: December 2009

Abstract
DFT-B3LYP and CASSCF calculations have been performed using a 6-31G* basis set to study photocycloaddition reactions of biradicals, generated by irradiation of 6-amino-2-(3-thienoyl)-1,4-benzoquinone, with ethylene. The calculated parameters of biradicals and transition states have also been compared with ground state parameters to completely elucidate the reaction mechanism of [2 + 2] and [3 + 2] photocycloaddition reactions. Preference for a particular cycloaddition pathway is ascertained by the relative stability between initially formed triplet biradical and another triplet biradical formed by hydrogen shift.
Local Structure around the Amino Group of Glycine Carbamate in Concentrated Aqueous Solutions
Authors: Kameda Yasuo , Amo Yuko , Usuki Takeshi 
Published: December 2009

Abstract
Neutron diffraction measurements were carried out on aqueous alkaline 2 mol % glycine heavy water solutions absorbing CO2. 14N/15N isotopic substitution was applied to obtain information on the molecular structure of glycine carbamate formed in the solution and the hydration structure around the nitrogen atom of the carbamate molecule. The least-squares fitting analysis of the higher-Q region of the observed first-order difference function Δ′N(Q) between 14N- and 15N-enriched sample solutions revealed that the intramolecular distances within the carbamate molecule, r(N–CC) = 1.58(1) Å and r(CC–OC) = 1.25(1) Å, where CC and OC denote the carbamate carbon and oxygen atoms, respectively. It was shown that on the average 2.1(2) D2O molecules were hydrogen-bonded to the amino-hydrogen atoms of the carbamate molecule with the intermolecular distances of r(N···OW) = 2.86(3) Å and r(N···DW) = 3.18(5) Å (OW: water oxygen, DW: water deuterium atoms), respectively.
197Au Mössbauer Spectroscopic Studies of Cyclometalated Gold Dimers Containing 2-C6F4PPh2 Ligands
Authors: Bennett Martin A , Mirzadeh Nedaossadat , Privér Steven H , Takahashi Masashi , Bhargava Suresh K 
Published: December 2009

Abstract
197Au Mössbauer spectra have been measured on a series of homovalent and heterovalent dinuclear gold complexes containing the 2-C6F4PPh2 ligand. The correlation plot indicates that the electron densities of the 6s and 6p orbitals of the gold atoms in these complexes are less than those of their protio and 6-methyl analogs, reflecting the electron-withdrawing property of the fluorine substituents.
Catalytic Electrosynthesis in Ionic Liquid: Performance of Nickel–(2,2′-Bipyridine) Complexes for Production of Aryl Propan-2-ones
Authors: Barhdadi Rachid , Maekawa Hirofumi , Comminges Clément , Troupel Michel 
Published: December 2009

Abstract
The nickel-catalyzed electroreductive coupling of a benzylic chloride with an acyl donor reagent in the ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate has been studied in the preparative scale to obtain aryl propan-2-ones in galvanostatic mode. Poor solubility of metallic salts prevents the use of the sacrificial anode process in an undivided cell. Moderate chemical yields are obtained within a divided cell configuration using an anionic membrane as a separator, which shows the compatibility of ionic liquids with this kind of electrochemical device. Aryl propan-2-ones were prepared with chemical yield up to 65%. Cyclic voltammetry and UV–vis spectroscopy confirm that the mechanism is the same in the ionic liquid and in a classical molecular solvent such as DMF. Nevertheless, degradation of the imidazolium cation induced by redox catalysis involving the bipyridine ligand has been observed, which explains the low faradaic yields.
Biomass Carbon Ratio of Biomass Chemicals Measured by Accelerator Mass Spectrometry
Authors: Funabashi Masahiro , Ninomiya Fumi , Kunioka Masao , Ohara Keiichi 
Published: December 2009

Abstract
The biomass carbon ratios of various chemical products were studied. The biomass carbon ratios of chemicals such as polymers, their monomers, starches, cellulose, calcium carbonate, charcoal, ethanol, and polymer blends were estimated by the ratios of 14C to 12C measured by accelerator mass spectrometry (AMS) based on ASTM D 6866. Preparations of the gaseous and liquid samples for the AMS measurements are described, and the pretreatment for carbonate is also explained. Repeatability and accuracy of the biomass carbon ratio evaluation by AMS are discussed. It was found that a new correction factor is necessary for cellulose other than 0.93, which is regulated as the correction factor for present modern carbon newer than 1950 in ASTM D 6866. The developed sample preparations of gaseous materials and carbonate were confirmed to be applicable for the AMS measurement of the biomass carbon ratio. The repeatability and accuracy of the biomass carbon ratio evaluation by AMS were confirmed for ethanol derived from biomass (bioethanol), a polymer blend of biomass-based poly(lactic acid) (PLA), and petroleum-based poly(butylene succinate) (PBS). Standard deviations of the bioethanol and the blend of PLA and PBS are 0.36 and 0.84%, respectively. The biomass carbon ratio evaluation by AMS has been proposed for the International Standard (ISO).