bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENYELESAIAN SENGKETA MELALUI LEMBAGA ALTERNATIF PENYELESAIAN SENGKETA (LAPS) PADA SECURITIES CROWDFUNDING DI INDONESIA
Authors: Suprapdi Suprapdi 
Published: April 2024

This article discusses dispute resolution of the risks faced by parties in securities crowdfunding in Indonesia through Alternative Dispute Resolution Institutions (LAPS). Securities crowdfunding itself is a refinement of equity crowdfunding, which has been running first. This is because equity crowdfunding cannot be utilized by small and medium enterprises (SMEs) or start-up companies because both are not limited liability company (PT) legal entities and only issue stock securities. This research uses normative juridical research methods and a legal research approach. The results of research on securities crowdfunding dispute resolution in Indonesia through LAPS were conducted by BAPMI because securities crowdfunding is included in the capital market sector. Dispute resolution in securities crowdfunding can be through internal dispute resolution forums (settlements are carried out by internal organizers) or external dispute resolution (settlements can be through LAPS and litigation).
Keywords: Dispute, LAPS, Securities Crowdfunding.
JUAL BELI DENGAN SISTEM ARISAN KABUPATEN KOTA WARINGIN TIMUR DESA SAMUDA
Authors: Amin Muhammad 
Published: April 2024

Along with its development, buying and selling have been carried out through the gathering system. Buying and selling with the gathering system aims to help meet the needs of the gathering participants and help sell merchant merchandise. Apart from the benefits, there are also several problems when buying and selling with this system, as happened in a village in Indonesia where gold is a commodity object. This type of research is empirical juridical research with a socio-legal approach. Data collection techniques in this study were observation, interviews, and documentation. This study aims to determine the practice of buying and selling using the gathering system in Samuda Village, East Kotawaringin Regency, Central Kalimantan. The result shows that buying and selling with the gathering system is istishna and permissible to implement. However, if there are gathering participants who default, it will provide a gap for losses to one of the parties. Then, the objects of buying and selling by the gathering system carried out by the people in the village are various kinds of goods. However, when the practice of buying and selling through the gathering system with gold jewelry objects, the law is prohibited based on the losses experienced by the gathering participants and the prohibition in Islam against crediting gold, it can be concluded that the law of gold gathering is unlawful. Hopefully, this research can provide understanding to the public to avoid harmful buying and selling and can increase Sharia buying and selling.
PENAFSIRAN KONSEP KONTEN YOUTUBE SEBAGAI BENTUK ASET YANG BISA DIIKAT OLEH FIDUSIA TINAJUAN HUKUM EKONOMI SYARIAH
Authors: Nurcahyo Febry Wahyu 
Published: April 2024

Saat ini, pemerintah mendukung bisnis kreatif melalui fasilitas perancangan pembiayaan hak kekayaan intelektual dengan tujuan agar bisnis kreatif, khususnya para YouTuber, dapat menggadaikan hak cipta pada saluran YouTube mereka melalui lembaga keuangan seperti Bank dan Non Bank.
Dalam konteks penelitian ini, akan dibahas permasalahan mengenai peraturan hukum terkait hak cipta yang berlaku terhadap saluran YouTube sebagai objek jaminan fidusia, serta mengidentifikasi hambatan-hambatan yang ada dalam menjadikan saluran YouTube sebagai objek jaminan fidusia. Penelitian ini merupakan studi hukum yang bersifat normatif, yang didukung analisis studi pustaka. Pendekatan yang digunakan dalam penelitian ini mencakup pendekatan perundang-undangan, pendekatan konseptual, dan pendekatan Analisis Ekonomi Hukum Syariah. Sumber data sekunder diperoleh dari perpustakaan.
Berdasarkan hasil studi pustaka yang telah dilakukan, disimpulkan bahwa hak cipta atas saluran YouTube memiliki potensi untuk menjadi objek jaminan fidusia sesuai dengan ketentuan yang terdapat dalam Pasal 16 Undang-Undang Nomor 28 Tahun 2014 tentang Hak Cipta, Undang-Undang Nomor 42 Tahun 1999 tentang Jaminan Fidusia, dan Peraturan Pemerintah Nomor 24 Tahun 2022 tentang Ketentuan Pelaksanaan Ekonomi Kreatif.
APPLICATION OF ENVIRONMENTALLY BASED EXPERIMENTAL METHODS TO IMPROVE LEARNING OUTCOMES IN ACID-BASE SOLUTION
Authors: Ismulyati Sri , Rahmi Rauzatur , Adiska Dessi Nur , Astryna Syarifah Yanti 
Published: April 2024

Based on the data obtained, the chemistry learning process still uses lecture and question-and-answer methods. Because of that the students are less active and the learning atmosphere is less enjoyable. It showed that there are still many students who are not happy when starting to learn. Students play around in learning activities; they experience difficulties and obstacles in learning, and do not understand the material presented by the teacher. The aim of this research was to determine whether environmental-based experimental methods can improve student learning outcomes in acid-based solution material in class VII of SMPN.2 Alafan, Simeulue Regency. This research method is descriptive-qualitative, which uses direct observation data on the classroom learning process. The research subjects were 19 students, consisting of 9 males and 10 females. The test was given in the form of multiple-choice questions with 20 questions. The research results showed that the completeness of student learning outcomes was 94.74%. This shows the results of learning using environmental-based experimental methods, especially on acid-based solution material.
PENGARUH MOTIVASI KERJA TERHADAP KINERJA KARYAWAN DENGAN PELAYANAN SEBAGAI VARIABEL MODERASI
Authors: Yabani Awang , Effendi Muhamad 
Published: April 2024

Masalah dalam penelitian ini adalah belum tercapainya hasil kerja yang baik, sehingga kinerja yang dilakukan karyawan belum sesuai dengan keinginan dan harapan Nasabah. Hasil pengujian hipotesis pertama dengan regresi liniear sederhana menemukan yang di peroleh nilai persamaan regresi liniear sederhana Y = a+bX (Kinerja Karyawan= 42,613+ 0,266 Motivasi Kerja). Jenis penelitian yang digunakan dalam penelitian ini menggunakan metode penelitian kualitatif. Teknik pengumpulan data dalam penelitian ini adalah observasi, kuesioner dan dokumentasi. Hasil penelitian ini menunjukan bahwa terdapat pengaruh antara variabel motivasi kerja terhadap kinerja karyawan dengan pelayanan sebagai variabel moderasi yang menunjukan nilai R Square sebesar 0,415 atau 41,5% meningkat sebesar 58,5% dari hasil nilai R Square sebelum adanya variabel moderasi (motivasi) sebesar 0,129 atau 12,9%.
The Interface between Human Rights and Terrorism: Towards Achieving an Effective Counter-Terrorism Regime
Authors: Shafiq Asma Bint , Faruque Abdullah Al 
Published: April 2024

Terrorism has become an emerging challenge to human rights protections today. Although terrorism has been present throughout modern history, international concern against it has become more visible since September 11, 2001. The international community has adopted various instruments on counterterrorism, provisions of which have been incorporated into the domestic laws of different countries. These instruments representing the current counterterrorism regime prioritise national security over other issues including human rights. Therefore, while employing counterterrorism measures states often tend to promote their security at the expense of the lives, liberties, and properties of civilians. To protect the human rights of innocent people against such actions it is crucial to adopt an effective counterterrorism regime. This article explores how states could establish such a regime. It suggests that the proposed regime should be based on the human rights framework. The principles of necessity and proportionality will provide a useful guideline in this respect.
Dhaka University Law Journal, Vol. 34(2), 2024 P. 1-23
Circulating mortalin in blood and activation of the alternative complement pathway as risk indicators in COVID-19 infection
Authors: Avraham Maya , Sinkovits György , Hurler Lisa , Prohászka Zoltán , Fishelson Zvi 
Published: April 2024

BackgroundMortalin/GRP75 is a ubiquitous mitochondrial chaperone related to the cytosolic heat shock protein 70. It protects cells from various types of damages and from senescence. Our goal was to determine whether COVID-19 patients have circulating mortalin in their blood and to assess its prognostic value in anticipating disease severity.MethodsMortalin was determined by ELISA in the sera of 83 COVID-19 patients enrolled in the study. Patients were categorized into 4 groups: critical patients who died (FATAL) or required intensive care and survived (ICU), patients of mild severity (hospitalized but not critical) who required nasal oxygen support (HOSP+O2), and patients who did not need oxygen therapy (HOSP).ResultsThe mortalin concentration in the serum of all COVID-19 patients in the cohort was 194-2324 pg/mL. A comparison of the mortalin levels by peak severity among the various patient groups showed a highly significant difference between the HOSP and FATAL groups and a significant difference between the HOSP and the ICU groups. COVID-19 patients who eventually failed to survive had at hospitalization a markedly higher level of mortalin in their sera. Cox regression analysis revealed a high mortality hazard (HR=3.96, p&lt;0.01) in patients with high mortalin circulating levels (above the median, ≥651 pg/mL). This was confirmed in survival curve analysis (Kaplan-Meier; p=0.0032, log-rank test). Mortalin remained an independent predictor of mortality even after adjusting for age and sex or various complement activation products. Complement activation data collected in an earlier study in the same cohort was compared regarding the mortalin levels. Patients with higher circulating mortalin levels also had higher levels of complement C3a but reduced levels of properdin.DiscussionThis is the first report on circulating mortalin in COVID-19 patients. Higher mortalin levels were associated with more severe illnesses and a higher risk of death. We claim that quantifying the blood levels of mortalin and activated complement proteins will provide important information on the prognosis of COVID-19 patients and will serve as a useful tool for guiding their clinical management and treatment.
Comparison between different advanced cannulation techniques for difficult biliary cannulation: a systematic review with a meta-analysis
Authors: Wang Liangjing , Wang Limin , Huang Nan , Li Tian , Shi Xiaohua , Zhu Qilin 
Published: April 2024

ObjectiveThis study aimed to systematically evaluate the efficacy and safety of the double-guidewire technique along with other methods (persistent standard cannulation techniques, transpancreatic sphincterotomy, and pancreatic stent-assisted technique) for difficult biliary cannulation.MethodsTwo researchers searched for literature on the efficacy and safety of the double-guidewire technique and other techniques in difficult biliary cannulation in databases, including PubMed, Embase, Cochrane, China National Knowledge Infrastructure, and Wanfang Data, based on the inclusion and exclusion criteria. The success rate of cannulation, duration of cannulation, post-ERCP pancreatitis, and overall postoperative complications were also analyzed using RevMan 5.4 software.ResultsIn total, 20 randomized controlled trial (RCT) studies involving 2008 participants were identified. The success rate of cannulation in the double-guidewire technique was much higher than that in persistent standard cannulation techniques [RR = 1.37, 95%CI (1.05, 1.79), p = 0.02]. However, it was lower than the success rate observed with transpancreatic sphincterotomy [RR = 0.89, 95%CI (0.81, 0.97), p = 0.01]. There was no significance in post-ERCP pancreatitis [RR = 1.09, 95% CI (0.85, 1.40), p = 0.49], overall postoperative complications [RR = 0.90, 95% CI (0.56, 1.45), p = 0.66], and duration of cannulation [SMD = -0.14, 95%C I (−1.43, 1.15), p = 0.83] between the double-guidewire technique and other techniques.ConclusionThis study demonstrated that the success rate of cannulation ranged from transpancreatic sphincterotomy to the double-guidewire technique and then to persistent standard cannulation techniques.
Effect of 0.01% atropine combined with orthokeratology lens on axial elongation: a 2-year randomized, double-masked, placebo-controlled, cross-over trial
Authors: Li Binbin , Yu Shiao , Gao Shasha , Sun Guangli , Pang Xuena , Li Xiuhong , Wang Ming , Zhang Fengyan , Fu Aicun 
Published: April 2024

PurposeTo evaluate the effect of 0.01% atropine combined with orthokeratology (OK) lens on axial elongation in schoolchildren with myopia.MethodsSixty children aged 8–12 years with spherical equivalent refraction (SER) from -1.00D to -4.00D in both eyes were enrolled in this randomized, double-masked, placebo-controlled, cross-over trial. Children who had been wearing OK lenses for 2 months were randomly assigned into combination group (combination of OK lens and 0.01% atropine) for 1 year followed by control group (combination of OK lens and placebo) for another 1 year or vice versa. This trial was registered in the Chinese Clinical Trial Registry (Number: ChiCTR2000033904, 16/06/2020). The primary outcome was changes in axial length (AL). Data of right eyes were analyzed.ResultsThere were statistically significant differences in the changes in AL between combination and control groups after generalized estimating equation model adjusting for age and baseline SER (p = 0.001). The mean axial elongation difference between combination and control groups was 0.10 mm in the first year (0.10 ± 0.13 mm vs. 0.20 ±0.15 mm; p = 0.01), and 0.09 mm in the second year (0.22 ± 0.10 mm vs. 0.13 ± 0.14 mm; p = 0.01), respectively. The mean axial elongation difference of two groups in the first year was similar to that in the second year during the cross-over treatment.ConclusionIn central Mainland China in myopic children, the treatment of combination therapy is more effective than single OK lens in controlling axial elongation.
Circulating plasma-derived extracellular vesicles expressing bone and kidney markers are associated with neurocognitive impairment in people living with HIV
Authors: Marques de Menezes Erika G. , Bowler Scott A. , Shikuma Cecilia M. , Ndhlovu Lishomwa C. , Norris Philip J. 
Published: April 2024

BackgroundAlthough effective antiretroviral therapy (ART) has improved the life expectancy of people with HIV (PWH), the prevalence of milder forms of HIV-associated neurocognitive disorders (HAND) persist, and it is associated with systemic and neuro-inflammatory processes that could impact other organ systems. However, the complex signaling mechanisms between the bone-kidney systems and the brain in HAND remain unknown. Extracellular vesicles (EVs) play a potential role in inter-organ communication and are involved in regulating cell activity in distant tissues. In this study, we examined whether levels of EVs from bone-and kidney-related cells associate with cognitive dysfunction and explored the relationship between kidney-bone EV axis in PWH experiencing cognitive deficits.MethodsEV subtypes were characterized in plasma from 61 PWH with either cognitive impairment (CI, n = 53) or normal cognition (NC, n = 8) based on the American Academy of Neurology criteria for HIV-associated dementia (HAD, n = 11), minor cognitive motor disorder (MCMD, n = 25) or asymptomatic neurocognitive impairment (ANI, n = 17) by spectral flow cytometry. EVs were profiled with markers reflecting bone and kidney cell origin. A support vector machine learning-based model was employed for analyses of EV phenotypes to predict the cognitive dysfunction.ResultsPlasma-EVs expressing osteocalcin, sclerostin, and nephrin were significantly higher in the cognitive impairment group compared to the normal cognition group. EVs bearing kidney cell markers correlated significantly with bone-derived EVs. A machine learning-based model, comprised of osteocalcin+, nephrin+, and CD24+ EVs predicted cognitive impairment in PWH on ART.ConclusionOur study reveals that neurocognitive impairment in PWH is associated with increased levels of plasma EVs enriched with the bone markers osteocalcin and sclerostin and the kidney marker nephrin, suggesting that these EV subtypes may be novel candidate biomarkers for disease-spanning neurocognitive dysfunction. Moreover, the relationship between bone-derived EVs with kidney-derived EVs may suggest their role in mediating inter-organ crosstalk in the pathogenesis of HIV-associated cognitive impairment.
Assessment of body composition in breast cancer patients: concordance between transverse computed tomography analysis at the fourth thoracic and third lumbar vertebrae
Authors: Daly Alex , Newman Lydia , Thomas Alexandra , Munro Alicia , Spence Cameron , Long Joe , Arnott Jonathan , Durkin Kesta , Layfield David , Heetun Adam , Wootton Stephen , Copson Ellen R. , Cutress Ramsey I. 
Published: April 2024

IntroductionSpecific body composition markers derived from L3 axial computed tomography (CT) images predict clinical cancer outcomes, including chemotherapy toxicity and survival. However, this method is only applicable to those undergoing lumbar (L3) CT scanning, which is not universally conducted in early breast cancer cases. This study aimed to evaluate CT analysis at T4 as a feasible alternative marker of body composition in breast cancer.MethodAll patients participated in the Investigating Outcomes from Breast Cancer: Correlating Genetic, Immunological, and Nutritional (BeGIN) Predictors observational cohort study (REC reference number: 14/EE/1297). Staging chest-abdomen-pelvic CT scan images from 24 women diagnosed with early breast cancer at University Hospital Southampton were analysed. Adipose tissue, skeletal muscle, and muscle attenuation were measured from the transverse CT slices’ cross-sectional area (CSA) at T4 and L3. Adipose tissue and skeletal muscle area measurements were adjusted for height. Spearman’s rank correlation coefficient analysis was used to determine concordance between body composition measurements using CT analysis at L3 and T4 regions.ResultsDerived estimates for total adipose tissue, subcutaneous adipose tissue, and intramuscular adipose tissue mass following adjustment for height were highly concordant when determined from CSAs of CT slices at T4 and L3 (Rs = 0.821, p &lt; 0.001; Rs = 0.816, p &lt; 0.001; and Rs = 0.830, p &lt; 0.001). In this cohort, visceral adipose tissue (VAT) and skeletal muscle estimates following height adjustment were less concordant when measured by CT at T4 and L3 (Rs = 0.477, p = 0.039 and Rs = 0.578, p = 0.003). The assessment of muscle attenuation was also highly concordant when measured by CT at T4 and L3 (Rs = 0.840, p &lt; 0.001).DiscussionThese results suggest that the CT analysis at T4 and L3 provides highly concordant markers for total adipose, subcutaneous adipose, and intramuscular adipose estimation, but not VAT, in this breast cancer population. High concordance between T4 and L3 was also found when assessing skeletal muscle attenuation. Lower concordance was observed for the estimates of skeletal muscle area, potentially explained by differences in the quantity and proportions of axial and appendicular muscle between the thorax and abdomen. Future studies will determine the value of T4 metrics as predictive tools for clinical outcomes in breast cancer.
Association between oxidative balance score in adults with and without chronic kidney disease: 2011–2028 NHANES
Authors: Cao Yuyu , Zhou Yishan , Zhong Yanghong , Liao Xianyong , Chen Xushan , Pi Ying 
Published: April 2024

IntroductionOxidative stress status is associated with CKD; however, few studies have investigated this association. The oxidative balance score (OBS) reflects systemic stress status and consists of 16 anti-and pro-oxidant dietary factors and four anti-and pro-oxidant lifestyle factors. Higher OBS implies exposure to more antioxidants. The purpose of this study was to explore the association between OBS and CKD.MethodsWe enrolled 8,134 study participants from the 2011–2018 National Health and Nutrition Examination Survey and obtained OBS by adding the 20 dietary and lifestyle factors. Based on OBS, the participants were divided into three groups. We performed logistic regression, subgroup analyzes, and restricted cubic spline regression to explore the association between OBS and CKD. In addition, we tested the adjusted model.ResultsOBS was negatively associated with CKD (OR: 0.54; 0.66, 0.82). After adjusting for all confounders, when dietary OBS was &gt;20, the prevalence of CKD was reduced by 42% for each unit increase in OBS (p &lt; 0.05). The negative associations of total OBS, dietary OBS, and lifestyle OBS with CKD were more significant in the female group. When the total OBS was ~20, the trend of decreasing prevalence in the female group was more significant.ConclusionOBS is negatively associated with chronic kidney disease.
Acoustic analysis of clients’ expression of self-compassion, self-criticism, and self-protection within emotion focused therapy video sessions
Authors: Bailey Ghazaleh , Halamová Júlia , Vráblová Viktória 
Published: April 2024

IntroductionWhen it comes to the non-verbal communication of emotions, it is apparent that the human voice is one of the main ways of expressing emotion and is increasingly important in psychotherapeutic dialog. There is ample research focusing on the vocal expression of emotions. However, to date the analysis of the vocal quality of clients’ in-sessional emotional experience remains largely unexplored. Moreover, there is generally a gap within the psychotherapy literature in the understanding of the vocal character of self-compassion, self-criticism, and protective anger.MethodsIn this study we investigated how clients vocally convey self-compassion, self-protection and self-criticism in Emotion Focused therapy sessions. For this purpose we investigated 12 commercially available Emotion Focused Therapy videos that employed a two chair or empty chair dialog. Praat software was used for the acoustic analysis of the most common features – pitch (known as fundamental frequency or F0) and intensity (voice amplitude, i.e., loudness).ResultsResults showed that intensity was significantly higher for self-criticism and self-protection than for self-compassion. Regarding pitch the findings showed no significant differences between the three states.DiscussionMore research analyzing acoustic features in a larger number of cases is required to obtain a deeper understanding of clients’ vocal expression of self-compassion, self-protection and self-criticism in Emotion Focused Therapy.