bluuebunny/crossref_metadata_2025_split huggingface dataset:
A genome-scale screen identifies sulfated glycosaminoglycans as pivotal in epithelial cell damage byCandida albicans
Authors: Lin Jianfeng , Miao Jian , Schaefer Katherine G. , Russell Charles M. , Pyron Robert J. , Zhang Fuming , Phan Quynh T. , Solis-Swidergall Norma V. , Liu Hong , Tashiro Masato , Dordick Jonathan S. , Linhardt Robert J. , Yeaman Michael R. , King Gavin M. , Barrera Francisco N. , Peters Brian M. , Filler Scott G. 
Published: May 2024

AbstractCandidalysin is a cytolytic peptide produced by the opportunistic fungal pathogenCandida albicans.This peptide is a key virulence factor in mouse models of mucosal and hematogenously disseminated candidiasis. Despite intense interest in the role of candidalysin inC. albicanspathogenicity, its host cell targets have remained elusive. To fill this knowledge gap, we performed a genome-wide loss-of-function CRISPR screen in a human oral epithelial cell line to identify specific host factors required for susceptibility to candidalysin-induced cellular damage. Among the top hits wereXYLT2,B3GALT6andB3GAT3, genes that function in glycosaminoglycan (GAG) biosynthesis. Deletion of these genes led to the absence of GAGs such as heparan sulfate on the epithelial cell surface and increased resistance to damage induced by both candidalysin and liveC. albicans.Biophysical analyses including surface plasmon resonance and atomic force and electron microscopy indicated that candidalysin physically binds to sulfated GAGs, facilitating its oligomerization or enrichment on the host cell surface. The addition of exogenous sulfated GAGs or the GAG analogue dextran sulfate protected cells against candidalysin-induced damage. Dextran sulfate, but not non-sulfated dextran, also inhibited epithelial cell endocytosis ofC. albicansand fungal-induced epithelial cell cytokine and chemokine production. In a murine model of vulvovaginal candidiasis, topical dextran sulfate administration reduced host tissue damage and decreased intravaginal IL-1β and neutrophil levels. Collectively, these data indicate that GAGs are epithelial cell targets of candidalysin and can be used therapeutically to protect cells from candidalysin-induced damage.
Sex and the facilitation of cued fear by prior contextual fear conditioning in rats
Authors: Vazquez Katherine , Cole Kehinde E. , Parsons Ryan G. 
Published: May 2024

AbstractPrevious studies have shown that the formation of new memories can be influenced by prior experience. This includes work using pavlovian fear conditioning in rodents that have shown that an initial fear conditioning experience can become associated with and facilitate the acquisition of new fear memories, especially when they occur close together in time. However, most of the prior studies used only males as subjects resulting in questions about the generalizability of the findings from this work. Here we tested whether prior contextual fear conditioning would facilitate later learning of cued fear conditioning in both male and female rats, and if there were differences based on the interval between the two conditioning episodes. Our results showed that levels of cued fear were not influenced by prior contextual fear conditioning or by the interval between training, however, females showed lower levels of cued fear. Freezing behavior in the initial training context differed by sex, with females showing lower levels of contextual fear, and by the type of initial training, with rats given delayed shock showing higher levels of fear than rats given immediate shock during contextual fear conditioning. These results indicate that contextual fear conditioning does not prime subsequent cued fear conditioning and that female rats express lower levels of cued and contextual fear conditioning than males.
Role of influencer–follower congruence in influencing followers’ food choices and brand advocacy: mediating role of perceived trust
Authors: Verma Simran , Kapoor Deepa , Gupta Ruchika 
Published: May 2024

PurposeThis study attempts to encapsulate the idea of influencer marketing in the food sector and the vital role played by food influencers in shaping the dietary preferences, tastes and decisions of their social media followers and turning them into brand advocates.Design/methodology/approachAn online survey of 383 social media users, utilizing a self-administered questionnaire, was undertaken to validate the proposed research design. The partial least squares structural equation modeling (PLS-SEM) methodology was used to analyze the data and test the relationships between the constructs.FindingsThe results confirm the validity and reliability of the research model. The research revealed the positive influence of influencer–follower demographics and attitude congruence on followers’ food choices, which in turn leads to followers’ delight and significantly impacts their brand advocacy. It also depicts how followers’ perceived trust in an influencer mediates the relationship between their similarity with the influencers, their food choices and brand advocacy.Originality/valueThe study proposes a new theoretical framework and empirically tests the effectiveness of influencer marketing in influencing social media users’ food choice behavior and brand advocacy through the medium of followers’ congruence with social media influencers. The findings offer noteworthy theoretical and managerial implications for academicians as well as marketing practitioners.
The bright side of flight delay: How do flight delays affect auditing quality?
Authors: Cheng Silu , Hu Wenyao 
Published: May 2024

Purpose This study explores how auditors' emotions, specifically negative moods triggered by flight delays, impact auditing quality.Design/methodology/approach Utilizing flight delays during audit assignments as a mood indicator, weather conditions at departure airports serve as an instrumental variable to provide a robustness check between flight delays and audit outcomes, employing a two-stage least squares model.Findings The findings suggest that such negative moods improve auditing effort and quality, as evidenced by reduced future accounting restatements and increased audit fees. The positive effect of flight delays on auditing quality is consistent across different tests and measures.Originality/value This study highlights the significance of auditors' emotional states on their professional performance, indicating a unique angle on auditing quality research by focusing on the emotional well-being of auditors as influenced by external factors such as flight delays.
Do personality traits affect entrepreneurial intention? The mediating role of the theory of planned behavior
Authors: Tsaknis Panagiotis A. , Sahinidis Alexandros G. 
Published: May 2024

Purpose
The purpose of this study is to determine the factors affecting entrepreneurial intention by combining the big five personality traits with the theory of planned behavior (TPB).

Design/methodology/approach
The study was conducted with the use of an online questionnaire. The sample was comprised of 257 students from the business department of a public university in Athens.

Findings
The results of this study indicated a statistically significant and positive relationship of openness, extraversion, attitude, and perceived behavioral control to entrepreneurial intention. Furthermore, there is a positive relationship of openness, conscientiousness and extraversion towards entrepreneurial intention through perceived behavioral control. Finally, the findings indicated a positive relationship of extraversion with entrepreneurial intention through attitude.

Research limitations/implications
The findings are limited to a specific student environment and should be replicated across various university settings to reach generalizable conclusions. The sample consists of only Greek students, which is another limitation of the study. The effects of entrepreneurship education vary with different ethnic backgrounds as seen in other studies. Finally, the research did not address the issue of gender or work experience among other variables discussed in other studies.

Practical implications
Several practical aspects of entrepreneurial intention can be considered, including entrepreneurship education, strategic investment, government and business organizations, mentoring issues and policymaking. This research can assist in various ways, enabling educational institutions to customize entrepreneurship courses, helping students choose suitable courses, aiding policymakers in developing supportive policies, and allowing organizations to identify employees with an entrepreneurial mindset.

Originality/value
Although the big five personality traits and the Theory of Planned Behavior have been combined in numerous fields such as behavioral economics, psychology, and health behaviors, their integration in studying entrepreneurial intention remains scant. With this approach, researchers can gain a deeper understanding of the factors that affect entrepreneurial intention.
Innovation strategy, digital transformation and competitive advantage of manufacturing enterprises: evidence from China
Authors: Xue Fang , Tan Yunqing , Anwar Sajid 
Published: May 2024

PurposeThis study aims to integrate the concepts of digital transformation, innovation strategy, and competitive advantage, into a novel research model in an effort to identify a more competitive path for digital transformation within manufacturing enterprises.Design/methodology/approachThe research model was tested through multivariate hierarchical regression analyses, and Hayes’ PROCESS for SPSS, utilizing survey data collected from 183 manufacturing enterprises in China.FindingsThe results indicate that, in comparison to research and development (R&D) and production, digital transformation in service and organizational activities exert a more significant impact on competitive advantage. Conversely, digital transformation in sales does not exhibit a significant impact on competitive advantage. Furthermore, in contrast to exploratory innovation and ambidexterity, exploitative innovation has a more pronounced influence on digital transformation. Additionally, digital transformation has been confirmed as a mediator in the relationship between innovation strategy and competitive advantage.Originality/valueThese findings expand our comprehension of digital transformation as an evolving process and shed light on the relationship between digital transformation and competitive advantage across various value-creating activities. This research serves as a valuable resource for decision-makers in selecting the most suitable path for digital transformation and configuring innovative resources.
Employee job security and job performance: the mediating role of well-being and the moderating role of perceived organizational support and psychological capital
Authors: Al Nahyan Moza Tahnoon , Al Ahbabi Jawaher Majdi , Alabdulrahman Mesheal Abdulmohsen , Alhosani Ibrahim , Jabeen Fauzia , Farouk Sherine 
Published: May 2024

PurposeGrounded in social cognitive career theory, this study investigates how employees' perceptions of job security and well-being affected their performance during the COVID-19 pandemic. It also examines the moderating effects of perceived organizational support and psychological capital on well-being and performance.Design/methodology/approachUsing a two-wave time-lagged design, data were collected from 279 frontline employees in public service organizations in Saudi Arabia.FindingsThe study’s results show that perceived job security significantly affects job performance. Employee well-being significantly and positively influences job performance and partially mediates the relationship between perceived job security and job performance. Additionally, perceived organizational support and psychological capital positively moderated the relationship between employee well-being and job performance during the pandemic.Practical implicationsThis study suggests that policymakers and practitioners need to prioritize addressing the job security concerns and well-being of frontline employees during a pandemic to enhance employee performance.Originality/valueOur findings present significant implications for policymakers in the context of job security and performance within public organizations in emerging countries.
Satisfaction of households in surrounding communities of protected areas with economic compensation for wildlife accidents: a case study of Xishuangbanna National Nature Reserve in China
Authors: Zhang Wei , Xie Mengling , Solomon Tamirat , Li Ming , Yin Xinan , Wang Changhai 
Published: May 2024

PurposeThis study aims to investigate the satisfaction of farmers with the compensation policy for wildlife-caused damages and its influencing factors, analyze the current situation of satisfaction with the compensation policy among farmers, identify factors significantly affecting satisfaction, and explore ways to optimize the compensation policy and improve the satisfaction of farmers based on the effects of various influencing factors.Design/methodology/approachThe Xishuangbanna National Nature Reserve in Yunnan Province, China, is selected as the research area for the study. Through field interviews, 370 valid questionnaires were collected to obtain relevant data on farmers' satisfaction with the compensation policy for wildlife-caused damages. The Oprobit model is utilized to explore the factors influencing farmer satisfaction and to analyze their underlying reasons.FindingsThe study reveals that farmers in the communities surrounding the Xishuangbanna National Nature Reserve generally experience low satisfaction with the compensation policy, particularly concerning satisfaction with compensation amounts, which tends to be dissatisfied on average. Satisfaction with the compensation policy is significantly influenced by individual characteristics and household labor structure, while the degree of human-wildlife conflict, wildlife conservation attitudes and household income structure have insignificant impact. Among individual characteristics, gender, education level, health status, and ethnicity are highly significant. In household labor structure, the number of agricultural laborers, non-agricultural laborers, and household agricultural labor time are highly significant.Originality/valueBuilding on the overall satisfaction of farmers with the compensation policy, this study further decomposes policy satisfaction into satisfaction with compensation amounts, coverage, and procedures. It provides more targeted recommendations for enhancing satisfaction with the compensation policy, which can help effectively mitigate human-wildlife conflicts and achieve harmonious coexistence between humans and nature.
Enterprise social networks and the work context: a case study of mandated use
Authors: Ollier-Malaterre Ariane , Redston Marianne 
Published: May 2024

PurposeEnterprise social networks (ESN) that enable faster communications and knowledge sharing at work are an integral part of many workplaces. Although the affordances potency and actualization constructs identify work context as important, few studies to date have teased out how the interactions between ESN’s affordances, users’ goals and the work context drive affordances actualization.Design/methodology/approachThis research is a case study of a technology multinational that made the ESN Chatter mandatory for all internal communications. We conducted a thematic analysis of 40 h of non-participatory observation, 15 in-depth interviews and eight informal conversations with employees.FindingsThere was considerable variation in how employees across different functional roles perceived affordances’ potencies, leading to differences in the nature and intensity of actualization: while sales and project managers embraced Chatter, technical support participants mostly resisted it; visibility was the central affordance for sales and human resources, but persistence was more important for project managers and association for technical support and billing. An organizational culture of accountability, urgency and efficiency interacted with Chatter’s affordances in a mutually reinforcing way, strengthening accountability and accelerating processes. Collaboration was enhanced but in a mostly coercive way. While sales participants' motivation was boosted, the mandated use of Chatter rendered tasks not inputted in Chatter invisible and created antagonism between departments.Practical implicationsPractitioners should not underestimate the influence of different work contexts and employees' goals when implementing an ESN. Since employees are concerned with managing their workload and how others perceive them, they may resist ESNs that they perceive as creating additional work and they may attempt to manage impressions at the expense of the work climate. Organizations looking to implement an ESN as their main communication tool would greatly benefit from establishing training programs and clear guidelines on positive communication practices across functional roles such as sales and technical support, and between peers.Originality/valueOur study is one of the first to shed light on the role of the work context, i.e. functional role and organizational culture, in explaining the intensity and specificity of affordance actualization across an organization.
The chronic illness of poverty: the effects of microfinance on the severity of poverty and the cost of its eradication
Authors: Hailat Mahmoud Ali , Alomari Mohammad W. , Bashayreh Ala' 
Published: May 2024

PurposeThis paper investigates the impact of microfinance on poverty gap which is the shortfall in income or consumption expenditures below $1.90, $3.20 and $5.50 per day. The paper’s primary goal is to investigate how microloans have impacted the severity of poverty and influenced the cost of poverty eradication in Latin America, empirically evaluate these effects and offer appropriate policy recommendations.Design/methodology/approachThis paper used panel data for 13 Latin American countries from world bank spanning the period 2001–2019 and Fully Modified Ordinary Least Squares model for heterogeneous cointegrated panels. This study used Gross Loan Portfolio per active borrowers, gross domestic product per capita, Gini index, Inflation and Unemployment rate as independent variables and poverty gaps as dependent variables.FindingsPoverty gaps narrow as the loan per borrower increases, and the degree of effect differs with the poverty line, with the magnitude increasing as the poverty line falls, underscoring microloans as an effective tool in closing poverty gaps and lowering the cost of poverty eradication. Growth of GDP per capita is helpful reducing the poverty gap, especially for the less poor of the poor. Inflation and unemployment have no to little impact on the severe poverty gaps, but they start to matter when the poverty line is $5.5 per day. Finally, income distribution inequality widens the poverty gap regardless of the poverty line used.Originality/valueThis study suggests several implications. For example, Latin American nations need to embrace tangible policies that encourage economic growth while reducing inequalities in income distribution to effectively eradicate poverty. More supportive environment is necessary to increase the effectiveness of microfinance operations, particularly for the poorest populations. Microfinance institutions need to set less stringent conditions for loan accessibility and repayment schedules that are commensurate with different levels of poverty. Finally, strengthening microfinance as a strategic policy to gradually close poverty gaps and reduce the cost of poverty eradication.
How coworker undermining leads justice-sensitive employees to miss deadlines
Authors: De Clercq Dirk , Azeem Muhammad Umer , Haq Inam Ul 
Published: May 2024

PurposeThis study examines how employees’ exposure to coworker undermining may lead them to miss work deadlines. It offers a particular focus on the mediating role of diminished organization-based self-esteem and the moderating role of justice sensitivity in this connection.Design/methodology/approachThe research hypotheses are tested with data collected among employees and supervisors who work in various industries.FindingsPurposeful efforts by coworkers to cause harm translate into an increased propensity to fail to complete work on time, because the focal employees consider themselves unworthy organizational members. The extent to which employees feel upset with unfair treatments invigorates this process.Practical implicationsFor employees who are frustrated with coworkers who deliberately compromise their professional functioning, diminished self-worth in relation to work and the subsequent reduced willingness to exhibit timely work efforts might make it more difficult to convince organizational leaders to do something about the negative coworker treatment. Pertinent personal characteristics can serve as a catalyst of this dynamic.Originality/valueThis study contributes to extant human resource management research by detailing the link between coworker undermining and a reduced propensity to finish work on time, pinpointing the roles of two hitherto overlooked factors (organization-based self-esteem and justice sensitivity) in this link.
Modernizing the photogrammetry curriculum by integrating the entrepreneurial mindset, bio-inspired design and STEAM approach
Authors: Elaksher Ahmed , Kotla Bhavana 
Published: May 2024

PurposePhotogrammetry enables scientists and engineers to make accurate and precise measurements from optical images and other patterns of reflected electromagnetic energy. Photogrammetry is taught in surveying, geomatics and similar academic programs. For a long time, it has been observed that there is a lack of diversity and underrepresentation of different groups in the surveying and geomatics workforces for various reasons. Diversity fosters more innovative environments, helps employees be more engaged and boosts productivity rates. Although efforts are being made to solve this problem, most attempts did not significantly improve the diversity issues in this field. To address this problem, we designed a new curriculum for a photogrammetry course, which integrates entrepreneurial mindset (EM), bio-inspired design and Science, Technology, Engineering, Arts and Mathematics (STEAM) into the photogrammetry course for this study.Design/methodology/approachIn this study, the participatory action research method, Photovoice, was used to gather data. Students were asked to respond to photovoice and metacognitive reflection prompts to understand student perceptions about the importance of Unmanned Aerial Vehicles (UAVs) in photogrammetric mapping. Students were required to respond to each prompt with three pictures and a narrative. These reflections were analyzed using thematic analysis.FindingsThe analysis of the photovoice and metacognitive reflections resulted in six themes: promoting digital literacy, promoting job readiness and awareness, improving perceived learning outcomes, increasing interest in pursuing careers in surveying/geomatics, encouraging learner engagement and increasing awareness of the role of art in map making.Originality/valueThis is the first study conducted at our Hispanic Serving Institution, which specifically designed a curriculum integrating EM, bio-inspired design and STEAM concepts to address diversity issues in surveying and geomatics engineering disciplines.