bluuebunny/crossref_metadata_2025_split huggingface dataset:
Skrining Bank Darah untuk Test Virus HIV di Kelurahan Tukmudal Kecamatan Sumber
Authors: Setiawan Fiki , Al Sas Oktafirani , Aji Rizal Ibrahim 
Published: May 2024

ABSTRAK Human Immunodeficiency Virus (HIV) adalah virus yang menyerang sistem kekebalan tubuh. Virusnya mampu menyebabkan imunitas tubuh menurun dalam melawan benda-benda asing. Transfusi darah dapat menimbulkan risiko penularan penyakit menular, terutama HIV/AIDS. Tingkat risiko penularan melalui transfusi dipengaruhi oleh faktor-faktor seperti tingkat penyakit di masyarakat, efektivitas skrining yang diterapkan, status kekebalan penerima, dan jumlah pendonor per unit darah. Oleh karena itu, setiap produk darah diwajibkan untuk menjalani proses skrining darah guna mencegah penyakit menular termasuk HIV/AIDS. Tujuan dari PKMD ini adalah membantu program puskesmas yang belum terlaksana mengenai Optimalisasi Skrining Bank Darah guna mendeteksi virus HIV. Metode yang digunakan adalah sosialisasi kepada masyarakat desa dengan membagikan kuesioner sebelum dilakukan pemeriksaan HIV secara kualitatif (Rapid Test). Hasil Skrining Bank Darah dari sampel Kelurahan Tukmudal yang berjumlah 48 orang, diperoleh hasil rata rata Hb sebesar 13,59 gr/dL. Rata-rata golongan darah A yang berjumlah 15 orang dengan persentase 31%, golongan darah B yang berjumlah 16 orang dengan persentase 34%, golongan darah 0 berjumlah 16 orang dengan persentase 33%, golongan darah AB yang berjumlah 1 orang dengan persentase 2%. Dan pemeriksaan imunoserelogi meliputi HCV dan HIV. Kata Kunci: HIV, AIDS, Skrining Bank Darah ABSTRACT Human Immunodeficiency Virus (HIV) is a virus that attacks the immune system. The virus can cause the body's immunity to decrease against foreign objects. Blood transfusions can pose a risk of transmission of infectious diseases, especially HIV/AIDS. The level of risk of transmission through transfusion is influenced by factors such as the level of disease in the community, the effectiveness of the screening applied, the immune status of the recipient, and the number of donors per unit of blood. Therefore, every blood product is required to undergo a blood screening process to prevent infectious diseases including HIV/AIDS. The purpose of this PKMD is to help the unimplemented puskesmas program regarding the Optimization of Blood Bank Screening to detect HIV. The method used is socialization to the village community by distributing questionnaires before qualitative HIV testing (Rapid Test). Blood Bank Screening Results from the sample of Tukmudal Village, which amounted to 48 people, obtained an average Hb result of 13.59 gr/dL. The average blood type A is 15 people with a percentage of 31%, blood type B is 16 people with a percentage of 34%, blood type 0 is 16 people with a percentage of 33%, and blood type AB is 1 person with a percentage of 2%. And immunocerelogy tests include HCV and HIV. Keywords: HIV, AIDS, Blood Bank Screening
Skrining Bank Darah untuk Pemeriksaan Sifilis di Kelurahan Pasalakan Kecamatan Sumber
Authors: Solikhah Solikhah , Supriyatin Supriyatin , Supenah Pipin 
Published: May 2024

ABSTRAK Sifilis atau penyakit raja singa merupakan penyakit Infeksi Menular seksual (IMS) yang disebabkan oleh bakteri Treponema pallidum. Penyakit sifilis dapat menular melalui hubungan seksual, transfusi darah, dan dari ibu ke janin. Tes serologis untuk deteksi antibodi mencakup tes rnon-treponemal untuk menyaring dan mengevaluasi pengobatan serta tes treponemal untuk Konfirmasi diagnosis. Berdasarkan standar WHO, jumlah kebutuhan minimal darah di Indonesia sekitar 5,1 juta kantong darah pertahun (2% jumlah penduduk Indonesia), Data Kementerian Kesehatan menunjukkan pada 2016, kebutuhan total kantong darah se-Indonesia sekitar 5,1 juta kantong tapi yang tersedia hanya 4,2 juta atau sekitar 81% dari kebutuhan. Artinya, masih ada sekitar 19% atau 1 juta kantong darah yang belum terpenuhi. Donor darah atau donasi darah di Indonesia naik dalam 10 tahun namun masih kurang 20%. Jumlah pendonor darah di Indonesia dalam 10 tahun terakhir terjadi peningkatan. Kegiatan ini bertujuan untuk mengetahui skrining donor darah untuk sifilis pada masyarakat Kelurahan Pesalakan Kec. Sumber Kab. Cirebon. Didapatkan hasil RPR dan TP Rapid reaktif (terinfeksi sifilis) sebanyak 0 orang dan dengan hasil non reaktif (tidak terinfeksi sifilis) Kelurahan Pasalakan sebanyak 45 orang. Kata Kunci: Skrining Bank Darah, Tes Serologi, Sifilis, Transfusi Darah ABSTRACT Syphilis or lion king disease is a sexually transmitted infectious disease (STI) caused by the bacterium Treponema pallidum. Serological tests for antibody detection include rnon-treponemal tests to filter and evaluate treatment as well as treponemal testing for confirmation of diagnosis. According to WHO standards, the minimum blood requirement in Indonesia is about 5.1 million blood bags per year (2% of the Indonesian population), according to data from the Ministry of Health, in 2016, the total needs of Indonesians in blood bags are about 5,1 million bags but are available only 4.2 million or about 81% of the needs. I mean, there's still about 19% or 1 million blood bags out of stock. The number of blood donors in Indonesia has increased in the last 10 years but is still below 20%. This activity aims to find out the screening of blood donors for syphilis in the community Kelurahan Pesalakan Kec. Source Kab. Cirebon. RPR and Rapid Reactive (infected with syphilis) results were obtained of 0 people and with non-reactive (non-infected) results of 45 people. Keywords: Blood Bank Screening, Serology Test, Syphilis, Blood transfusion.
The Effect of Booklet Education on Mothers' Knowledge Related to Stunting
Authors: Hany Alfrina , Vatmasari Ratih Arum , Putri Farah Oktaviani , Alizain Azmy Avi 
Published: May 2024

ABSTRACT The growth and development of children is impacted by stunting, a serious public health issue. Mother knowledge is one aspect that affects stunting. Stunting-related education by booklets could improve mothers' awareness. To analyze the effect of education using booklets on maternal knowledge related to stunting. The study design used was a pre-experiment with a one group pre-test and post-test approach. The sample in this study were mothers who had children aged 0-5 years. The sampling technique used purposive sampling. The instrument used was a stunting knowledge questionnaire. The results of the Wilcoxon-test statistical test showed that there was a significant effect before and after education using booklets on mothers' knowledge related to stunting (p value = 0.002). Therefore, it can be concluded that providing education using booklets is effective in increasing mothers' knowledge related to stunting. Nurses could provide education using educational media such as booklets to increase mothers' knowledge related to stunting. Keywords: Education, Booklet, Stunting, Mothers' Knowledge
Pengaruh Pengetahuan Ibu Post Partum Terhadap Pemberian Kolostrum Pada Bayi Baru Lahir di BPM Nurul Hidayah
Authors: Ningrum Widya Pratiwi , Ningsih Sukarni Setya 
Published: May 2024

ABSTRACT UNICEF and WHO recommend optimal breastfeeding in order to reduce child morbidity and mortality. Children should get breast milk immediately after birth which is known as Early Breastfeeding Initiation. WHO says that giving colostrum in the first hour of a baby's life can strengthen the baby's immune system and can support successful breastfeeding. Breast milk contains colostrum which is rich in antibodies because it contains protein for immunity and is useful for killing germs in high numbers so that exclusive breastfeeding can reduce the risk of death in infants. Knowing the effect of knowledge of post partum mothers on giving colostrum to newborns. Analytical with cross sectional approach. The sample in this study were all postpartum mothers who gave birth at BPM Nurul Hidayah Bekasi in May - June 2023 as many as 30 people. The sampling technique used the total sampling technique. the majority of postpartum mothers gave colostrum 76.7% and most of them were knowledgeable enough 46.7%. There is a relationship between the knowledge of postpartum mothers and giving colostrum to newborns (p.value 0.002). There is a relationship between the knowledge of postpartum mothers and giving colostrum to newborns. It is hoped that postpartum mothers with good knowledge can also change their behavior well so that they can continue to give exclusive breastfeeding to their babies Keywords: Knowledge, Colostrum, Newborn baby ABSTRAK UNICEF dan WHO merekomendasikan ASI secara optimal dalam rangka menurunkan angka kesakitan dan kematian anak. Anak sebaiknya mendapatkan ASI segera setelah dilahirkan yang disebut sebagai Inisiasi Menyusui Dini. WHO mengatakan bahwa pemberian kolostrum pada jam pertama kehidupan seorang bayi dapat memperkuat daya tahan tubuh bayi dan dapat mendukung keberhasilan menyusui. ASI mengandung kolostrum yang kaya akan antibodi karena mengandung protein untuk daya tahan tubuh dan bermanfaat untuk mematikan kuman dalam jumlah tinggi sehingga pemberian ASI eksklusif dapat mengurangi risiko kematian pada bayi. Mengetahui pengaruh pengetahuan ibu post partum terhadap pemberian kolostrum pada bayi baru lahir. Analitik dengan pendekatan cross sectional. Sampel dalam penelitian ini adalah Seluruh ibu nifas yang melakukan persalinan di BPM Nurul Hidayah Bekasi pada bulan Mei - Juni 2023 sebanyak 30 orang. Teknik pengambilan sampel menggunakan teknik total sampling. Mayoritas ibu nifas memberikan kolostrum 60,0% dan sebagian besar berpengetahuan kurang 40,0%. Ada pengaruh pengetahuan ibu nifas terhadap pemberian kolostrum pada bayi baru lahir (p.value 0,003). Ada hubungan pengetahuan ibu nifas terhadap pemberian kolostrum pada bayi baru lahir. Diharapkan Ibu nifas dengan pengetahuan yang baik dapat merubah perilakunya dengan baik pula sehingga dapat melanjutkan untuk memberikan ASI eksklusif pada bayinya. Kata Kunci: Pengetahuan, Kolostrum, Bayi Baru Lahir
Hubungan Peran Orang Tua Terhadap Perkembangan Motorik Pada Anak Usia 1-2 Tahun di Wilayah Kerja Puskesmas Telagasari Kabupaten Karawang
Authors: RizkaPuriUtami Nuralya , Wintarsih Wintarsih 
Published: May 2024

ABSTRACT The growth and development of children is referred to as the golden age because at this time the physical condition as well as all the abilities of the child are developing rapidly, namely all movements that can be obtained by the whole body and motor development can be referred to as the development of elements of maturity and control of body movements. To determine the relationship between the role of parents and motor skills in children aged 1 - 2 years in the working area of the Telagasari Health Center. This research was conducted using quantitative research methods with cross sectional analysis using Chi square. Based on statistical results, it shows that the role of parents in motor development in children 1-2 years own p-value 0,000 < 0,05. There is a relationship between the role of parents on motor development in children aged 1 - 2 years in the working area of the Telagasari Health Center, Karawang Regency in 2023 the next researcher is expected to add other variable. Keyword: Parental Role, Motoric Development, Parenting ABSTRAK Pertumbuhan dan perkembangan anak disebut sebagai masa keemas an, karena pada masa ini keadaan fisik maupun segala kemampuan anak sedang berkembang cepat. Motorik yaitu semua Gerakan yang mungkin didapat oleh seluruh tubuh dan perkembangan motorik dapat disebut sebagai perkembangan dari unsur kematangan dan pengendalian gerak tubuh. Untuk mengetahui Hubungan Peran Orang Tua Terhadap Perkembangan Motorik Pada Anak Usia 1-2 Tahun di Wilayah Kerja Puskesmas Telagasari Kabupaten Karawang Tahun 2023. Penelitian ini dilakukan dengan menggunakan metode penelitian kuantitatif dengan cross secsional. Dengan menggunakan Analisa chi-square. Berdasarkan hasil statistik menunjukan bahwa Peran Orang Tua Terhadap Perkembangan Motorik Pada Anak Usia 1-2 memiliki p-value 0,000 < 0,05. Terdapat hubungan antara peran orang tua terhadap perkembangan motorik pada anak usia 1-2 tahun di Wilayah Kerja Puskesmas Telagasari Kabupaten Karawang tahun 2023. Peneliti selanjutnya diharapkan untuk menambah variabel yang lain. Kata Kunci: Peran Orang Tua, Perkembangan Motorik, Pola Asuh
The unmet drug-related needs of patients with diabetes in Ethiopia: a systematic review and meta-analysis
Authors: Gobezie Mengistie Yirsaw , Tesfaye Nuhamin Alemayehu , Solomon Tewodros , Demessie Mulat Belete , Wendie Teklehaimanot Fentie , Belayneh Yaschilal Muche , Baye Assefa Mulu , Hassen Minimize 
Published: May 2024

BackgroundDiabetes is a major health concern globally and in Ethiopia. Ensuring optimal diabetes management through minimizing drug therapy problems is important for improving patient outcomes. However, data on the prevalence and factors associated with unmet drug-related needs in patients with diabetes in Ethiopia is limited. This systematic review and meta-analysis aims to provide a comprehensive analysis of the prevalence of unmet drug-related needs among patients with diabetes mellitus in Ethiopia.MethodsA thorough exploration of databases, including PubMed, Scopus, Hinari, and Embase and Google Scholar, was conducted to identify pertinent studies. Inclusion criteria involved observational studies that reported the prevalence of unmet drug-related needs in Ethiopian patients with diabetes. The quality of the studies was assessed using Joanna Briggs Institute (JBI) checklists. A random-effects meta-analysis was employed to amalgamate data on study characteristics and prevalence estimates, followed by subsequent subgroup and sensitivity analyses. Graphical and statistical assessments were employed to evaluate publication bias.ResultsAnalysis of twelve studies involving 4,017 patients revealed a pooled prevalence of unmet drug-related needs at 74% (95% CI 63-83%). On average, each patient had 1.45 unmet drug-related needs. The most prevalent type of unmet need was ineffective drug therapy, 35% (95% CI 20-50). Type 2 diabetes, retrospective study designs, and studies from the Harari Region were associated with a higher prevalence. Frequently reported factors associated with the unmet drug-related needs includes multiple comorbidities, older age, and polypharmacy. Notably, the results indicated significant heterogeneity (I2 = 99.0%; p value &lt; 0.001), and Egger’s regression test revealed publication bias with p&lt;0.001.ConclusionThe prevalence of unmet drug-related needs among diabetes patients with diabetes in Ethiopia is high with the most prevalent issue being ineffective drug therapy. Targeted interventions are needed; especially patients on multiple medications, advanced age, with comorbidities, and prolonged illness duration to improve diabetes management and outcomes.Systematic review registrationhttps://www.crd.york.ac.uk/prospero, identifier CRD42024501096.
Assessing breast self-examination knowledge, attitude and practice as a secondary prevention of breast cancer among female undergraduates at the University of Dodoma: a protocol of analytical cross-sectional study
Authors: Masawa Glory , Mboineki Joanes Faustine 
Published: May 2024

BackgroundBreast cancer is a global disease affecting an enormous number of women worldwide and a primary cause of cancer-related deaths in women. In Tanzania, women's breast cancer is the second-ranked among all types of cancers, with an incidence of 15.9%. Despite the Breast Self Examination (BSE) being one of the secondary prevention of breast cancer and an important measure for early diagnosis of breast cancer, little is known whether women could practice routine BSE.ObjectivesThe study aims to Assess breast self-examination (BSE) knowledge, attitude, and practice among female undergraduates at the University of Dodoma.MethodologyAn institutionally-based analytical cross-sectional study will be carried out in the Dodoma region of Tanzania through a validated questionnaire. The study will involve 384 female undergraduate students aged 18 years. The data will be entered and analyzed in the Statistical Package for Social Sciences (SPSS) Version 25. Descriptive analysis (frequencies and percentages) and inferential statistics [Cross-tabulation, Chi-square (χ2), and Regression analysis] will be used.ConclusionThe practice of BSE among women remains unsatisfactory, which is highly linked to the lack of BSE knowledge. The deficit knowledge is on how to perform BSE, the benefit of BSE, and the interval of doing BSE. Most of the women seem to possess a positive attitude towards BSE.
Exploring the impact of a KCNH2 missense variant on Long QT syndrome: insights into a novel gender-selective, incomplete penetrance inheritance mode
Authors: Chen Peng , Zampawala Zainul , Wang Hong , Wang Luyun 
Published: May 2024

BackgroundLong QT syndrome (LQTS) is an inherited malignant arrhythmia syndrome that poses a risk of sudden death. Variants in the Potassium Voltage-Gated Channel Subfamily H Member 2 (KCNH2) gene are known to cause Long QT syndrome through an autosomal dominant inheritance pattern. However, as of now, there have been no reports of any KCNH2 variant leading to Long QT syndrome exhibiting incomplete penetrance that is influenced by gender.MethodsWhole-exome sequencing (WES) was conducted on the proband to identify pathogenic variants. Subsequently, Sanger sequencing was employed to validate the identified likely pathogenic variants in all family members.ResultsWe analyzed a pedigree spanning three-generations afflicted by Long QT syndrome. WES revealed a novel KCNH2 missense variant (p.Val630Gly, c.1889 T&gt;G) as the causative factor for the family’s phenotype. Within this family, all three male carriers of the KCNH2 variant carriers exhibited the Long QT syndrome phenotype: one experienced sudden death during sleep, another received an implantable cardioverter defibrillator (ICD), and a younger man displayed a prolonged QTc interval without any instances of syncope or malignant arrhythmia to date. Interestingly, the middle-aged female carrier showed no Long QT Syndrome phenotype. However, her offspring, diagnosed with Turner syndrome (45, X) and also a carrier of this variant, experienced frequent syncope starting at 12 years old and was diagnosed with Long QT syndrome, leading to an ICD implantation when she was 15 years old. These observations suggest that the manifestation of Long QT syndrome associated with this KCNH2 variant exhibits incomplete penetrance influenced by gender within this family, indicating potential protective mechanisms against the syndrome in females affected by this variant.ConclusionOur investigation has led to the identification of a novel pathogenic KCNH2 variant responsible for Long QT syndrome within a familial context characterized by gender-selective, incomplete penetrance. This discovery highlights a unique pathogenic inheritance pattern for the KCNH2 gene associated with Long QT syndrome, and could potentially shed light on the distinct penetrance behaviors and patterns of the KCNH2 gene. This discovery broadens our exploration of the KCNH2 gene in cardiac arrhythmias, highlighting the intricate genetic dynamics behind Long QT syndrome.
Traditional, complementary, and alternative medicine and the provision of health care to internally displaced persons in South Kivu, Democratic Republic of the Congo
Authors: Kazamwali Muzee , Kisanga Arsène , Balegamire Juvenal B. , Kaningini Euphrasie , Falisse Jean-Benoît , Furaha Germaine , Mapendo Denise M. , Boeyink Clayton 
Published: May 2024

IntroductionTraditional, complementary and alternative medicine (TCAM) providers are central for many when seeking healthcare. Internally Displaced Persons (IDPs) are no exception. This paper seeks to better understand the use of TCAM by IDPs and its connection with the local integration of IDPs into the social fabric of the communities where they have taken refuge. We compare IDPs and non-IDPs access to TCAM providers and their level of confidence in having their healthcare needs met by these sources in Uvira and Kabare territories of South Kivu, Democratic Republic of Congo (DRC).MethodsWe draw from a mixed method, social connections design comprised of participatory workshops with 111 participants; a survey with 847 participants capturing exploring access and trust of TCAM and other wealth and demographic indicators; 24 interviews with traditional healthcare providers; and 56 in-depth life history interviews with IDPs. Collected data were analysed using both qualitative and quantitative approaches. Descriptive statistics (mean, percentage, and standard deviation) and statistical tests (proportions test and t test) were used as quantitative analysis tools whereas thematic content analysis was used for qualitative data.ResultsWe show that IDPs use TCAM more than non IDPs. Access to and trust in traditional healers seems dependent on the exact nature of the services they offer, which varies across our sample. As such, processes of recognition and integration of both IDPs and TCAM providers into formal healthcare systems should be treated cautiously with an understanding of the socio-economic rationales that displaced people and TCAM providers operate under. While many of these TCAM providers are not highly trusted sources in South Kivu, their highly valued treatment of certain conditions such as what is locally known as “mulonge” (and bears similarities with the Buruli ulcer) suggest there may be potential specific areas where collaboration could be successful between biomedical health workers and TCAM providers.
Extracellular CIRP promotes Kupffer cell inflammatory polarization in sepsis
Authors: Shimizu Junji , Murao Atsushi , Lee Yongchan , Aziz Monowar , Wang Ping 
Published: May 2024

IntroductionSepsis is a life-threatening inflammatory condition caused by dysregulated host responses to infection. Extracellular cold-inducible RNA-binding protein (eCIRP) is a recently discovered damage-associated molecular pattern that causes inflammation and organ injury in sepsis. Kupffer cells can be activated and polarized to the inflammatory M1 phenotype, contributing to tissue damage by producing proinflammatory mediators. We hypothesized that eCIRP promotes Kupffer cell M1 polarization in sepsis.MethodsWe stimulated Kupffer cells isolated from wild-type (WT) and TLR4-/- mice with recombinant mouse (rm) CIRP (i.e., eCIRP) and assessed supernatant IL-6 and TNFα levels by ELISA. The mRNA expression of iNOS and CD206 for M1 and M2 markers, respectively, was assessed by qPCR. We induced sepsis in WT and CIRP-/- mice by cecal ligation and puncture (CLP) and assessed iNOS and CD206 expression in Kupffer cells by flow cytometry.ResultseCIRP dose- and time-dependently increased IL-6 and TNFα release from WT Kupffer cells. In TLR4-/- Kupffer cells, their increase after eCIRP stimulation was prevented. eCIRP significantly increased iNOS gene expression, while it did not alter CD206 expression in WT Kupffer cells. In TLR4-/- Kupffer cells, however, iNOS expression was significantly decreased compared with WT Kupffer cells after eCIRP stimulation. iNOS expression in Kupffer cells was significantly increased at 20 h after CLP in WT mice. In contrast, Kupffer cell iNOS expression in CIRP-/- mice was significantly decreased compared with WT mice after CLP. CD206 expression in Kupffer cells was not different across all groups. Kupffer cell M1/M2 ratio was significantly increased in WT septic mice, while it was significantly decreased in CIRP-/- mice compared to WT mice after CLP.ConclusionOur data have clearly shown that eCIRP induces Kupffer cell M1 polarization via TLR4 pathway in sepsis, resulting in overproduction of inflammatory cytokines. eCIRP could be a promising therapeutic target to attenuate inflammation by preventing Kupffer cell M1 polarization in sepsis.