bluuebunny/crossref_metadata_2025_split huggingface dataset:
Classification of single‐voxel 1H spectra of childhood cerebellar tumors using lcmodel and whole tissue representations
Authors: Raschke Felix , Davies Nigel P. , Wilson Martin , Peet Andrew C. , Howe Franklyn A. 
Published: August 2012

AbstractIn this study, mean tumor spectra are used as the basis functions in LCModel to create a direct classification tool for short echo time 1H magnetic resonance spectroscopy of pediatric brain tumors. LCModel is a widely used analysis tool designed to fit a linear combination of individual metabolite spectra to in vivo spectra. Here, we have used LCModel to fit mean spectra and corresponding variability components of childhood cerebellar tumors, as calculated using principal component analysis, and assessed for classification accuracy. Classification was performed according to the highest estimated tumor proportion. This method was tested in a leave‐one‐out analysis discriminating between pediatric brain tumor spectra of medulloblastoma vs. pilocytic astrocytoma and medulloblastoma vs. pilocytic astrocytoma vs. ependymoma. Additionally, the effect of accepting different Cramér‐Rao Lower Bound cut‐off criteria on classification accuracy and estimated tissue proportions was investigated. The best classification results differentiating medulloblastoma vs. pilocytic astrocytoma and medulloblastoma vs. pilocytic astrocytoma vs. ependymoma were 100 and 87.7%, respectively. These results are comparable to a specialized pattern recognition analysis of this data set and give easy to interpret results in the form of estimated tissue proportions. The method requires minimal user input and is easily transferable across sites and to other magnetic resonance spectroscopy classification problems. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.
Proton pump inhibitors and traditional nonsteroidal anti‐inflammatory drugs and the risk of acute interstitial nephritis and acute kidney injury
Authors: Leonard Charles E. , Freeman Cristin P. , Newcomb Craig W. , Reese Peter P. , Herlim Maximilian , Bilker Warren B. , Hennessy Sean , Strom Brian L. 
Published: August 2012

ABSTRACTPurposeThis study aims to examine the associations between proton pump inhibitors (PPIs), traditional nonsteroidal anti‐inflammatory drugs (tNSAIDs), PPI + tNSAID co‐exposure, and the development of the following: (i) acute interstitial nephritis (AIN), a specific kidney injury often attributed to these drugs, and (ii) acute kidney injury (AKI), a general kidney injury encompassing AIN.MethodsTwo retrospective case–control studies were conducted, one for each outcome, within the General Practice Research Database. Cases were diagnostic‐coded AIN (primary outcome) or AKI (secondary outcome) events. Controls were matched on age, sex, and general practitioner practice. Exposures were defined by the presence/absence of the following mutually exclusive therapies on the index date: (i) PPI alone; (ii) tNSAID alone; (iii) PPI + tNSAID; or (iv) neither PPI nor tNSAID (referent).ResultsSixty‐eight AIN cases and 3347 controls were identified. The adjusted odds ratios (ORs) for PPI and tNSAID exposures alone were 3.20 (0.80–12.79) and 1.90 (0.65–5.51), respectively. Numerous sensitivity analyses produced adjusted ORs for AIN between 3.0 and 7.7, and 1.6 and 1.9, respectively. We identified 27 982 AKI cases and 1 323 850 controls. The adjusted ORs for PPI alone, tNSAID alone, and PPI + tNSAID exposures were 1.05 (0.97–1.14), 1.31 (1.25–1.37), and 1.33 (1.07–1.64), respectively. Numerous sensitivity analyses produced adjusted ORs for AKI between 1.0 and 1.1, 1.1 and 1.3, and 1.3 and 1.4, respectively.ConclusionsProton pump inhibitor exposure may increase the odds of AIN, but this result was not definitive and should be confirmed in a dataset with more AIN cases to allow for increased statistical precision. tNSAIDs, yet not PPIs, were associated with a significantly increased odds of AKI. Copyright © 2012 John Wiley & Sons, Ltd.
Synthesis and properties of novel high oil‐absorbing resin based on poly(ethylene‐propylene‐diene/ α‐methylstyrene/itaconic acid)
Authors: Zhou Xiao‐Ming , Chuai Cheng‐Zhi 
Published: August 2012

AbstractA novel high oil‐absorbing resin, P(EPDM/α‐MSt/ITA), was synthesized by suspension copolymerization with ethylene‐propylene‐diene (EPDM), α‐methylstyrene (α‐MSt), and itaconic acid (ITA) as monomers, benzoyl peroxide as initiator, and divinylbenzene as crosslink agent in this study. By using methods such as infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy, we studied the oil‐absorbing resin structure, oil‐absorption rate, oil‐absorption saturation time, and submicroscopic structure of oil‐absorption resin after oil absorption. The experiment results show that the highest oil absorptivity of the resin was about 21.9 g/g in diesel oil, obviously increasing the oil absorptive properties by the addition of itaconic acid as reaction monomer. We can draw a conclusion from scanning electron microscopy observation of sample after oil absorption that the oil‐absorption resin was filled with diesel oil, and a kind of morphology structure similar with embossment can be produced during the oil‐absorbing process. The oil‐absorbing resin was used repeatedly through the extraction by ethanol. Experiment result proved to have little effect on oil‐absorption properties. Otherwise, the oil‐absorption rate constant K of novel high oil‐absorbing resin was evaluated for diesel oil, and the oil‐absorbing process obeyed the first‐order kinetics equation. POLYM. ENG. SCI. 2013. © 2012 Society of Plastics Engineers
Structure and performance of temperature‐sensitive poly(vinylidene fluoride) hollow fiber membrane fabricated at different take‐up speeds
Authors: Shen Xiang , Zhao Yiping , Chen Li , Feng Xia , Yang Duo , Zhang Qiang , Su Dan 
Published: August 2012

AbstractGraft copolymer (PVDF‐g‐PNIPAAm) having poly(vinylidene fluoride) (PVDF) backbones and poly(N‐isopropylacrylamide) (PNIPAAm) side chains was synthesized via radical copolymerization and its hollow fiber membrane was fabricated from dry–wet spinning technique with N, N‐dimethylformamide as the solvent and poly(ethylene glycol) (10,000) as the additive. The effects of spinning condition (take‐up speeds) on the structures and performances of resulting fiber membranes were systematically considered. The structures and performances of fiber membranes were characterized by element analysis, X‐ray photoelectron spectroscopy, water contact angle measurement, scanning electron microscope, atom force microscope, and filtration experiments. The results indicate that PNIPAAm side chains tended to enrich on the membrane surface and pore surface and especially tended to aggregate on the inner surface due to the effect of bore fluid. The hollow fiber membrane exhibits an obvious temperature‐sensitive property. The pure water flux increases remarkably around 32°C, while the retention of albumin egg decreases accordingly, when the permeation temperature rises from 20 to 45°C. As the take‐up speed increases, both the inner and outer diameters of fiber membranes decrease. A higher take‐up speed favors higher pure water permeation flux, which allows larger molecules to permeate through the fiber membrane. POLYM. ENG. SCI. 2013. © 2012 Society of Plastics Engineers
The preparation and adsorption properties of electrospun aramid nanofibers
Authors: Wei Zhimei , Zhang Quanchao , Wang Lihua , Peng Minle , Wang Xiaojun , long Shengru , Yang Jie 
Published: August 2012

AbstractThe focus of this work is the preparation of aramid nanofibers via electrospinning technology and the study of their adsorption properties. In this article, aramid nanofibers were prepared by electrospinning aramid fibers solution with the addition of lithium chloride (LiCl). It showed a good adsorption capacity when methylene blue (MB) was used as the model target. There were much larger adsorption amounts and faster kinetics of uptaking target species of electrospun aramid nanofibers to MB than that of electrospun polyethersulfone (PES) nanofibers. Compared with activated carbon, aramid nanofibers also have a much faster adsorption rate to MB. Aramid nanofibers were subsequently used to effectively remove endocrine disruptors such as bisphenol A (BPA), phenol (Phe), and p‐hydroquinone (BPhe) from their aqueous solutions. Additionally, molecule imprinted technology enhances aramid nanofibers with much higher adsorption amounts and special adsorption property for endocrine disruptors. These results showed that aramid nanofibers have the potential to be used in environmental applications. © 2012 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2012
Engineered variants of InlB with an additional leucine‐rich repeat discriminate between physiologically relevant and packing contacts in crystal structures of the InlB:MET complex
Authors: Niemann Hartmut H. , Gherardi Ermanno , Bleymüller Willem M. , Heinz Dirk W. 
Published: August 2012

AbstractThe physiological relevance of contacts in crystal lattices often remains elusive. This was also the case for the complex between the invasion protein internalin B (InlB) from Listeria monocytogenes and its host cell receptor, the human receptor tyrosine kinase (RTK) MET. InlB is a MET agonist and induces bacterial host cell invasion. Activation of RTKs generally involves ligand‐induced dimerization of the receptor ectodomain. The two currently available crystal structures of the InlB:MET complex show the same arrangement of InlB and MET in a 1:1 complex, but different dimeric 2:2 assemblies. Only one of these 2:2 assemblies is predicted to be stable by a computational procedure. This assembly is mainly stabilized by a contact between the Cap domain of InlB from one and the Sema domain of MET from another 1:1 complex. Here, we probe the physiological relevance of this interaction. We generated variants of the leucine‐rich repeat (LRR) protein InlB by inserting an additional repeat between the first and the second LRR. This should allow formation of the 1:1 complex but disrupt the potential 2:2 complex involving the Cap‐Sema contact due to steric distortions. A crystal structure of one of the engineered proteins showed that it folded properly. Binding affinity to MET was comparable to that of wild‐type InlB. The InlB variant induced MET phosphorylation and cell scatter like wild‐type InlB. These results suggest that the Cap‐Sema interaction is not physiologically relevant and support the previously proposed assembly, in which a 2:2 InlB:MET complex is built around a ligand dimer.
Expression differences of circulating microRNAs in metastatic castration resistant prostate cancer and low‐risk, localized prostate cancer
Authors: Nguyen Han Christine Ngoc , Xie Wanling , Yang Ming , Hsieh Chen‐Lin , Drouin Sarah , Lee Gwo‐Shu Mary , Kantoff Philip W. 
Published: August 2012

AbstractBACKGROUNDRecent studies show that microRNAs (miRNAs), small non‐coding RNAs that negatively regulate gene expression, may have potential for monitoring cancer status. We investigated circulating miRNAs in prostate cancer that may be associated with the progression of hormone‐sensitive primary tumors to metastatic castration resistant prostate cancer (CRPC) after androgen deprivation therapy.METHODSUsing genome‐wide expression profiling by TaqMan Human MicroRNA Arrays (Applied Biosystems) and/or quantitative real‐time polymerase chain reaction, we compared the expression levels of miRNAs in serum samples from 28 patients of low‐risk localized disease, 30 of high‐risk localized disease and 26 of metastatic CRPC.RESULTSWe demonstrated that serum samples from patients of low risk, localized prostate cancer and metastatic CRPC patients exhibit distinct circulating miRNA signatures. MiR‐375, miR‐378*, and miR‐141 were significantly over‐expressed in serum from CRPC patients compared with serum from low‐risk localized patients, while miR‐409‐3p was significantly under‐expressed. In prostate primary tumor samples, miR‐375 and miR‐141 also had significantly higher expression levels compared with those in normal prostate tissue.CONCLUSIONSCirculating miRNAs, particularly miR‐375, miR‐141, miR‐378*, and miR‐409‐3p, are differentially expressed in serum samples from prostate cancer patients. In the search for improved minimally invasive methods to follow cancer pathogenesis, the correlation of disease status with the expression patterns of circulating miRNAs may indicate the potential importance of circulating miRNAs as prognostic markers for prostate cancer progression. Prostate 73: 346–354, 2013. © 2012 Wiley Periodicals, Inc.
Ab‐Initio study of Helium‐small carbon cage systems
Authors: Cheng Cheng , Sheng Li 
Published: August 2012

AbstractThe traditional method for opening the electron shells of noble gas atoms involves a strong electronegative atom or group. However, this approach is limited to only heavy noble‐gas atoms, such as Kr and Xe. In this paper, we performed accurate calculations of He@C8H8 and He@C10H16 and showed the possibility of opening the electron shell of a light noble‐gas atom. © 2012 Wiley Periodicals, Inc.
Cognitive Appraisals, Coping and Depressive Symptoms in Breast Cancer Patients
Authors: Bigatti Silvia M. , Steiner Jennifer L. , Miller Kathy D. 
Published: August 2012

AbstractDepression in breast cancer patients and survivors is related to negative disease outcomes and worse quality of life. Factors that explain this depression can serve as targets of intervention. This study, guided by the Transactional Theory of Stress, examined the relationship between cognitive appraisals, coping strategies and depressive symptoms in a group of women with mostly advanced‐stage breast cancer (N = 65), who scored mostly within the normal range for depressive symptoms. Path analysis was used to determine the relationships among variables, measured with the Cognitive Appraisals of Illness Scale, the Ways of Coping Questionnaire and the Center for Epidemiological Studies Depression Scale. The results of the path analysis showed that higher appraisals of harm/loss and greater use of escape–avoidance coping predicted higher depressive symptoms. These findings enhance the prediction of depression among breast cancer patients and suggest the need to examine cognitive appraisals when attempting to understand depressive symptoms. Copyright © 2012 John Wiley & Sons, Ltd.
RDB2RDF: A relational to RDF plug‐in for Eclipse
Authors: Marx Edgard , Salas Percy , Breitman Karin , Viterbo José , Casanova Marco Antonio 
Published: August 2012

SUMMARYThe process of transforming data stored in relational databases (RDBs) into sets of Resource Description Framework (RDF) triples is known as triplification or RDB2RDF. It consists of two consecutive operations, schema extraction and data conversion. Schema extraction is a process similar to creating an external schema, and contains a collection of database views. The data conversion is divided into two steps. The first step consists of deciding how to represent database schema concepts in terms of RDF classes and properties, defining an RDB2RDF mapping. The second step consists of the actual conversion of relational data to RDF data instances, based on the mapping previously defined. Although the schema extraction is very well understood, the data conversion operation is still murky. Indeed, the World Wide Web Consortium RDB2RDF Working Group has been working to define a standard language, called R2RML, to describe RDB2RDF mapping files. The definition of the R2RML, however, is still undergoing changes. In this paper, we introduce an Eclipse plug‐in that supports the entire conversion process. Its architecture takes into consideration the specificities of the triplification process by providing a modular structure that encapsulates the stable and well‐understood components separately from the volatile, change‐prone mapping strategies. The latter are accessible via a well‐defined interface to promote information hiding and separation of concerns and to facilitate evolution. Copyright © 2012 John Wiley & Sons, Ltd.
Studies on various structural system design options for twisted tall buildings and their performances
Authors: Moon Kyoung Sun 
Published: August 2012

SUMMARYEmploying twisted forms for tall buildings is a recent architectural phenomenon. This paper studies various structural system design options for twisted tall buildings and their performances based on lateral stiffness. Twisted tall buildings of various heights and rates of twist are designed with different types of contemporary tall building structural systems, such as diagrids, braced tubes and outrigger systems. The heights of the studied buildings range from 60 to 100 stories, and the rates of twist range from 0° to 3° per floor. As the rate of twist increases, the lateral stiffness of the tower decreases. The stiffness reduction rate caused by twisting is very much dependent upon the structural systems employed for twisted tall buildings. While an emphasis is placed on the structural performance of twisted tall buildings, other aspects, such as architectural and constructional issues, are also discussed holistically. Copyright © 2012 John Wiley & Sons, Ltd.
Greenland climate change: from the past to the future
Authors: Masson‐Delmotte Valérie , Swingedouw Didier , Landais Amaëlle , Seidenkrantz Marit‐Solveig , Gauthier Emilie , Bichet Vincent , Massa Charly , Perren Bianca , Jomelli Vincent , Adalgeirsdottir Gudfinna , Hesselbjerg Christensen Jens , Arneborg Jette , Bhatt Uma , Walker Donald A. , Elberling Bo , Gillet‐Chaulet Fabien , Ritz Catherine , Gallée Hubert , van den Broeke Michiel , Fettweis Xavier , de Vernal Anne , Vinther Bo 
Published: August 2012

AbstractClimate archives available from deep sea and marine shelf sediments, glaciers, lakes, and ice cores in and around Greenland allow us to place the current trends in regional climate, ice sheet dynamics, and land surface changes in a broader perspective. We show that, during the last decade (2000s), atmospheric and sea surface temperatures are reaching levels last encountered millennia ago, when northern high latitude summer insolation was higher due to a different orbital configuration. Records from lake sediments in southern Greenland document major environmental and climatic conditions during the last 10,000 years, highlighting the role of soil dynamics in past vegetation changes, and stressing the growing anthropogenic impacts on soil erosion during the recent decades. Furthermore, past and present changes in atmospheric and oceanic heat advection appear to strongly influence both regional climate and ice sheet dynamics. Projections from climate models are investigated to quantify the magnitude and rates of future changes in Greenland temperature, which may be faster than past abrupt events occurring under interglacial conditions. Within one century, in response to increasing greenhouse gas emissions, Greenland may reach temperatures last time encountered during the last interglacial period, approximately 125,000 years ago. We review and discuss whether analogies between the last interglacial and future changes are reasonable, because of the different seasonal impacts of orbital and greenhouse gas forcings. Over several decades to centuries, future Greenland melt may act as a negative feedback, limiting regional warming albeit with global sea level and climatic impacts.WIREs Clim Change2012 doi: 10.1002/wcc.186This article is categorized under:Paleoclimates and Current Trends > Modern Climate Change
Evaluation of the effects of september hunting seasons on Canada geese in Nebraska
Authors: Groepper Scott R. , Vrtiska Mark P. , Powell Larkin A. , Hygnstrom Scott E. 
Published: August 2012

AbstractPopulations of temperate‐nesting Canada geese (Branta canadensis) have increased in Nebraska, USA, resulting in an increased number of nuisance and damage complaints. September hunting seasons were initiated in southeastern Nebraska in 2004 to reduce populations of Canada geese. We analyzed band recoveries from Canada geese banded in southeastern Nebraska during their hatch‐year (HY) or after‐hatch‐year (AHY) to determine whether September hunting seasons affected survival, harvest, and recovery rates. Survival analyses revealed that HY geese had higher survival than AHY geese (SAHY = 0.696, 95% CI = 0.679–0.713; SHY = 0.896, 95% CI = 0.786–0.953) and September seasons did not affect survival of geese in southeastern Nebraska. Geese banded in the geographic zone with the September seasons (southeastern Nebraska) had the same survival as did geese outside the hunt zone (northeastern Nebraska; S = 0.711, 95% CI = 0.666–0.752). September hunting seasons affected timing of band recovery; 23–49% of annual band recoveries occurred during the month of September. Prior to the initiation of the September seasons, the highest percent of recoveries occurred during November. The September seasons appeared to temporally redistribute harvest but did not reduce survival for populations of Canada geese in southeastern Nebraska. Continuation of the season may not be warranted, because management does not appear to be affecting AHY survival, which is needed to reduce the population. Additional or new methods are likely needed to control populations of temperate‐nesting Canada geese in Nebraska and managers should evaluate the effectiveness of these methods as they are implemented. © 2012 The Wildlife Society.
The golden‐cheeked warbler: History of a conflict
Authors: Groce Julie E. , Smith Kathryn N. , Wilkins R. Neal , Wolfe David 
Published: August 2012

AbstractWildlife biologists are undoubtedly familiar with the decades‐long debate over the Endangered Species Act and the conflicts that often arise among people of differing interests when a species is listed as federally threatened or endangered. One example that made local and national headlines in the 1990s was the golden‐cheeked warbler (Setophaga chrysoparia), which breeds exclusively in central Texas, USA, and primarily on private lands. The inclusion of the warbler on the federal endangered species list in 1990 prompted conflict between land developers, environmentalists, ranchers, and the U.S. Fish and Wildlife Service. Miscommunication and mistrust among the groups resulted in purposeful destruction of habitat and delayed or lost opportunities for species' conservation and scientific research. Now, 20 years later, we have taken the opportunity to review some of the events and conflicts surrounding the listing of the warbler such that a new generation of researchers and biologists can understand the progress made and identify where additional work may be needed. The significance of threatened and endangered species conservation varies among people and places; thus, there will be a continual need for agencies and biologists to develop relationships with local communities formed around understanding the values and motivations of all stakeholders, in an effort to limit conflict and create an atmosphere that promotes cooperative approaches to research on, and recovery of, at‐risk species. © 2012 The Wildlife Society.