bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inertial Sensor-Based Feedback Can Reduce Key Risk Metrics for Anterior Cruciate Ligament Injury During Jump Landings
Authors: Dowling Ariel V. , Favre Julien , Andriacchi Thomas P. 
Published: March 2012

Background: The incidence of anterior cruciate ligament (ACL) injury can be decreased through the use of intervention programs. However, the success of these programs is dependent on access to a skilled trainer who provides feedback; as such, these programs would benefit from a simple device with the capacity to provide high-quality feedback. Hypothesis: Feedback based on kinematic measurements from a simple inertial sensor-based system can be used to modify key ACL injury risk metrics (knee flexion angle, trunk lean, knee abduction moment) during jump landing. Study Design: Controlled laboratory study. Methods: Seventeen subjects (7 male) were tested during drop jump tasks. Their movements were measured simultaneously with inertial, optoelectronic, and force platform systems. Feedback provided to the subjects was based only on measurements from the inertial sensor-based system (knee flexion angle, trunk lean, and thigh coronal velocity). The subjects conducted a baseline session (without landing instructions), then a training session (with immediate feedback), and finally an evaluation session (without feedback). The baseline and evaluation sessions were then tested for changes in the key risk metrics. Results: The subjects increased their knee flexion angle (16.2°) and trunk lean (17.4°) after the training. They also altered their thigh coronal angular velocity by 29.4 deg/s and reduced their knee abduction moment by 0.5 %BW·Ht. There was a significant correlation ( R2 = 0.55) between the change in thigh coronal angular velocity and the change in knee abduction moment. Conclusion: Subjects reduced key risk metrics for ACL injury after training with the system, suggesting the potential benefit of instrumented feedback for interventional training. Clinical Relevance: Interventional training for reducing the risk of ACL injury could be improved with a simple device that provides immediate feedback.
News Media Outreach and Newspaper Coverage of Tobacco Control
Authors: Pederson Linda L. , Nelson David E. , Babb Stephen , London Joel , Promoff Gabbi , Pechacek Terry 
Published: March 2012

Introduction. Little is known about the impact of media outreach on news media coverage of tobacco control. Methods. Media outreach data were obtained from the Centers for Disease Control and Prevention’s Office on Smoking and Health (CDC/OSH) from 2003 to 2006; one to six types of outreach activities for 50 scientific publications were performed during 35 discrete time periods. The authors analyzed quantitatively and qualitatively 205 newspaper articles generated based on the CDC/OSH scientific publications. Results. Media coverage of specific CDC/OSH-related tobacco themes was highest for disparities (100%) and tobacco statistics (98%). More outreach activities increased the likelihood of moderate pickup of the number of themes in newspaper articles (odds ratio = 2.0, 95% confidence interval = 1.5-2.8), but there appeared to be a ceiling effect. Certain types of outreach were more strongly associated with front page and headline coverage. Conclusions. The extent and type of outreach were associated with increased newspaper coverage but the relationship is not necessarily straightforward. Additional research is needed to better understand relationships between scientific findings, outreach, and news media coverage of tobacco.
STI571 reduces TRAIL-induced apoptosis in colon cancer cells: c-Abl activation by the death receptor leads to stress kinase-dependent cell death
Authors: Huang Duen-Yi , Chao Yee , Tai Ming-Hui , Yu Yang-Hao , Lin Wan-Wan 
Published: March 2012

Abstract

Background
In an effort to achieve better cancer therapies, we elucidated the combination cancer therapy of STI571 (an inhibitor of Bcr-Abl and clinically used for chronic myelogenous leukemia) and TNF-related apoptosis-inducing ligand (TRAIL, a developing antitumor agent) in leukemia, colon, and prostate cancer cells.

Methods
Colon cancer (HCT116, SW480), prostate cancer (PC3, LNCaP) and leukemia (K562) cells were treated with STI571 and TRAIL. Cell viability was determined by MTT assay and sub-G1 appearance. Protein expression and kinase phosphorylation were determined by Western blotting. c-Abl and p73 activities were inhibited by target-specific small interfering (si)RNA. In vitro kinase assay of c-Abl was conducted using CRK as a substrate.

Results
We found that STI571 exerts opposite effects on the antitumor activity of TRAIL. It enhanced cytotoxicity in TRAIL-treated K562 leukemia cells and reduced TRAIL-induced apoptosis in HCT116 and SW480 colon cancer cells, while having no effect on PC3 and LNCaP cells. In colon and prostate cancer cells, TRAIL caused c-Abl cleavage to the active form via a caspase pathway. Interestingly, JNK and p38 MAPK inhibitors effectively blocked TRAIL-induced toxicity in the colon, but not in prostate cancer cells. Next, we found that STI571 could attenuate TRAIL-induced c-Abl, JNK and p38 activation in HCT116 cells. In addition, siRNA targeting knockdown of c-Abl and p73 also reduced TRAIL-induced cytotoxicity, rendering HCT116 cells less responsive to stress kinase activation, and masking the cytoprotective effect of STI571.

Conclusions
All together we demonstrate a novel mediator role of p73 in activating the stress kinases p38 and JNK in the classical apoptotic pathway of TRAIL. TRAIL via caspase-dependent action can sequentially activate c-Abl, p73, and stress kinases, which contribute to apoptosis in colon cancer cells. Through the inhibition of c-Abl-mediated apoptotic p73 signaling, STI571 reduces the antitumor activity of TRAIL in colon cancer cells. Our results raise additional concerns when developing combination cancer therapy with TRAIL and STI571 in the future.
The burden of antenatal heart disease in South Africa: a systematic review
Authors: Watkins David A , Sebitloane Motshedisi , Engel Mark E , Mayosi Bongani M 
Published: March 2012

Abstract

Background
Maternal mortality in South Africa is rising, and heart conditions currently account for 41 per cent of indirect causes of deaths. Little is known about the burden of heart disease in pregnant South Africans.

Methods
We systematically reviewed the contemporary epidemiology and peripartum outcomes of heart disease in South African women attending antenatal care. Searches were performed in PubMed, ISI Web of Science, the EBSCO Africa-Wide database, the South African Union Catalogue, and the Current and Completed Research database (South Africa). References of included articles were also hand-searched. Studies reporting epidemiologic data on antenatal heart disease in South Africa were included. Data on morbidity and mortality were also collected.

Results
Seven studies were included in the systematic review. The prevalence of heart disease ranged from 123 to 943 per 100,000 deliveries, with a median prevalence of 616 per 100,000. Rheumatic valvular lesions were the commonest abnormalities, although cardiomyopathies were disproportionately high in comparison with other developing countries. Peripartum case-fatality rates were as high as 9.5 per cent in areas with limited access to care. The most frequent complications were pulmonary oedema, thromboembolism, and major bleeding with warfarin use. Perinatal mortality ranged from 8.9 to 23.8 per cent, whilst mitral lesions were associated with low birth weight. Meta-analysis could not be performed due to clinical and statistical heterogeneity of the included studies.

Conclusion
Approximately 0.6 per cent of pregnant South Africans have pre-existing cardiac abnormalities, with rheumatic lesions being the commonest. Maternal and perinatal morbidity and mortality continue to be very high. We conclude this review by summarising limitations of the current literature and recommending standard reporting criteria for future reports.
Expression TGM2 and BNIP3 have prognostic significance in laryngeal cancer patients receiving surgery and postoperative radiotherapy: A retrospective study
Authors: Jin Ting , Lin Huan-Xin , Lin Hui , Guo Li-Bing , Ge Nan , Cai Xiu-Yu , Sun Rui , Chen Wen-Kuan , Li Qiu-Li , Hu Wei-Han 
Published: March 2012

Abstract

Background
This study was designed to determine the pattern and correlation between expression of the HIF-1α transcriptional targets TGM2 and BNIP3 in laryngeal cancer, and investigate the association of BNIP3 and TGM2 with clinical outcome in laryngeal squamous cell carcinoma (SCC) patients receiving postoperative radiotherapy.

Methods
Immunostaining with antibodies specific to BNIP3 and TGM2 was performed in formalin-fixed, paraffin-embedded specimens from 148 laryngeal SCC patients. BNIP3 and TGM2 expression was scored as high or low, based on the number of tumor cells stained and the staining intensity. All patients received postoperative radiotherapy. Patient follow up and clinicopathological data were compared using the Chi-squared test, univariate and multivariate analyses, and survival curves were generated using the Kaplan-Meier method and log-rank test.

Results
The 3, 5 and 10-year overall survival rates (OS) for all patients were 77.7%, 71.6%, 56.4%, respectively. Primary tumor site, T stage, overall stage, lymph-node metastasis, BNIP3 expression and TGM2 expression were significant prognostic factors for OS in univariate analysis. Negative cervical lymph nodes, high BNIP3 expression and low TGM2 expression were independent prognostic factors of improved OS in multivariate analysis. BNIP3 expression correlates with TGM2 expression in laryngeal SCC (P = 0.012).

Conclusions
This study indicates that lymph-node metastasis, BNIP3 expression and TGM2 expression are independent prognostic factors in laryngeal SCC patients receiving postoperative radiotherapy. Further studies are required to investigate how BNIP3 and/or TGM2 influence the prognosis of laryngeal SCC patients treated with postoperative radiotherapy, and to determine how TGM2 and BNIP3 expression are regulated.
Successful mobilization using a combination of plerixafor and G-CSF in pediatric patients who failed previous chemomobilization with G-CSF alone and possible complications of the treatment
Authors: Hong Kyung Taek , Kang Hyoung Jin , Kim Nam Hee , Kim Min Sun , Lee Ji Won , Kim Hyery , Park Kyung Duk , Shin Hee Young , Ahn Hyo Seop 
Published: March 2012

Abstract
Peripheral blood stem cell (PBSC) mobilization, which uses plerixafor (AMD 3100), a newly developed specific inhibitor of the CXCR4 receptor, in combination with granulocyte-colony stimulating factor(G-CSF), has been shown to enhance the stem cell mobilization in adult patients, but pediatric data are scarce. We documented our experience with this drug in 6 Korean pediatric patients who had failed in chemomobilization, using G-CSF, alone. All patients were mobilized CD34+ cells (median, 11.08 × 106/kg: range, 6.34-28.97 × 106/kg) successfully within 2 to 3 cycles of apheresis, without complications. A total of 7 autologous transplantations were performed, including 1 tandem transplantation. However, 2 patients with brain tumors showed severe pulmonary complications, including spontaneous pneumomediastinum. This is the first study of PBSC mobilization with plerixafor in Asian pediatric patients. Furthermore our study suggests that mobilization with plerixafor may be effective in Korean pediatric patients, who have previously been heavily treated and have failed PBSC mobilization with classical chemomobilization, using G-CSF. However, further studies are needed to examine the possible complications of autologous transplantation, using a mobilized plerixafor product in children.
A decade plus of translation: what do we understand?
Authors: Wang Xiangdong , Marincola Francesco M 
Published: March 2012

AbstractIt has been more than a decade that the term “Translational” (medicine, Research, Science) has trickled through the minds of academics, clinicians, business persons, regulators, policy makers, patients and their families, patient advocates, politicians and the public. Although the term means different things for different stake holders, it reflect and eagerness to see a fruitful outcome of the resources invested in biotechnology to benefit primarily the patients but also provide financial return for those who invested. Skeptics remain who feel the concept if abused by those attempting to deviate funds for basic or clinical research to a new domain performing similar tasks under a different egida. In reality, translational sciences are not different in scope any from previous efforts to focus the goals of research toward the relevant object of helping the disabled. The difference is that, in recent decades, awareness has risen about the difficulties of reaching this goal. In particular, it has become clear that the difficulties are not limited to scientific challenges, but to a myriad of hurdles that make testing and licensing of novel concepts unnecessarily burdensome. Moreover, it was recognized that the infrastructure to support clinical research is frequently outdated and inappropriate. The biggest hurdle, however, remains the cost and the length of clinical testing that could prolong of decades the application of even the most successful treatments. As for any expanding field, a plethora of journals has appeared with “Translational” in their title. This is a positive sign of the growth in interest for the field and the need to respond to a need for editorial boards competent in the challenges of judging clinical testing. In this editorial, we will discuss the meaning of translational medicine, its goals and needs; we will summarize the remaining challenges and will provide a personal overview of the strategies that remain to be implemented.
Role of MMPs in orchestrating inflammatory response in human monocytes via a TREM-1-PI3K-NF-κB pathway
Authors: Gómez-Piña Vanesa , Martínez Eriel , Fernández-Ruíz Irene , del Fresno Carlos , Soares-Schanoski Alessandra , Jurado Teresa , Siliceo María , Toledano Victor , Fernández-Palomares Rosa , García-Rio Francisco , Arnalich Francisco , Biswas Subhra K , López-Collazo Eduardo 
Published: March 2012

ABSTRACTThe MMPs constitute a family of endopeptidases that can cleavage extracellular proteins. They are involved in a number of events; some of these include inflammatory processes. One of its targets is the TREM-1, which has emerged as an important modulator of innate immune responses in mammals. This transmembrane glycoprotein possesses an Ig-like ectodomain readily shed by MMPs to generate sTREM-1. Whereas membrane-anchored TREM-1 amplifies inflammatory responses, sTREM-1 exhibits anti-inflammatory properties. Here we show that sustained cell surface expression of TREM-1 in human monocytes, through metalloproteinase inhibition, counteracts the well-characterized down-regulation of several proinflammatory cytokines during the ET time-frame, also known as M2 or alternative activation. In addition to the cytokines profile, other features of the ET phenotype were underdeveloped when TREM-1 was stabilized at the cell surface. These events were mediated by the signal transducers PI3Ks and Syk. We also show that sTREM-1 counteracts the proinflammatory response obtained by membrane TREM-1 stabilization but failed to induce ET on naïve human monocytes. As the sustained TREM-1 expression at the cell surface suffices to block the progress of a refractory state in human monocytes, our data indicate that TREM-1 and MMPs orchestrate an “adaptive” form of innate immunity by modulating the human monocytes response to endotoxin.
Prospective risk of stillbirth: monochorionic diamniotic twins vs. dichorionic twins
Authors: Morikawa Mamoru , Yamada Takashi , Yamada Takahiro , Sato Shoji , Cho Kazutoshi , Minakami Hisanori 
Published: March 2012

Abstract

Aims: To determine reliably the risk of stillbirth among twin pregnancies.

Methods: A data analysis of 3241 and 6581 women with monochorionic diamniotic (MD) and dichorionic (DD) twins, respectively, who gave birth at ≥22 weeks of gestation.

Results: The prospective risk (per 1000 women) of stillbirth, 25.3 and 11.5 at gestational week 22, decreased to <10.0 at gestational weeks 31 and 28 among the MD and DD twins, respectively. After single intrauterine fetal death, the co-twin died in utero or within 7 days of life more frequently among MD twins than among DD twins [42.7% (35/82) vs. 2.6% (2/76); relative risk, 16.2; 95% confidence interval, 4.0–65.1].

Conclusion: Women with MD twins were 2.2-fold more likely to experience stillbirth than women with DD twins. The prospective risks of stillbirth were <1.0% for both groups of women at ≥32 weeks of gestation.
Cross-over training in neonatology and obstetrics
Authors: Ismail Abdul Qader Tahir 
Published: March 2012

Abstract
Neonatology is a relatively new subspeciality of paediatrics, and before this, newborn babies were often managed by obstetricians. The two fields are closely related in the continuity of care that is being provided, and both specialities involve difficult and critical decisions. From personal experience, training in both specialities, even at a junior level, allows a greater understanding of the complexities surrounding these choices and their implications. As such, I propose a short period of mandatory training in both specialities for anyone considering a career in either.
ZnO Coated Nanoparticle Phosphors
Authors: Kobayashi Masakazu 
Published: March 2012

ABSTRACTConventional phosphor materials are doped ternary or quaternary compounds; hence it would be difficult to prepare nanoparticles of those materials by build up methods. Ba2ZnS3:Mn (BZS), SrGa2S4:Eu, and BaAl2S4:Eu nanoparticles were prepared by a break down method, namely the ball-milling method. Transmission electron microscopy (TEM) and TEM- energy-dispersive X-ray spectroscopy (EDX) measurements showed several-nanometer-size stoichiometric and dispersed nanoparticles were achieved. ZnO-coating was performed and the uniform coating layers were formed on the phosphor nanoparticles. The ZnO-coated nanoparticles exhibited an improved stability in Photoluminescence. Red color phosphor material, namely BZS, was ball-milled and sprayed on the glass substrate. Mn doped BZS absorbs ultra violet light and emits red light peaking at around 640nm. When the single crystal Si solar cell was placed under the transparent nanoparticle layer, short wavelength light was absorbed and converted to long wavelength light.
Potential Bone Replacement Materials Prepared by Two Methods
Authors: Lee Steve , Porter Michael , Wasko Scott , Lau Grace , Chen Po-Yu , Novitskaya Ekaterina E. , Tomsia Antoni P. , Almutairi Adah , Meyers Marc A. , McKittrick Joanna 
Published: March 2012

ABSTRACTNatural and synthetic hydroxyapatite (HA) scaffolds for potential load-bearing bone implants were fabricated by two methods. The natural scaffolds were formed by heating bovine cancellous bone at 1325°C, which removed the organic and sintered the HA. The synthetic scaffolds were prepared by freeze-casting HA powders, using different solid loadings (20–35 vol.%) and cooling rates (1–10°C/min). Both types of scaffolds were infiltrated with polymethylmethacrylate (PMMA). The porosity, pore size, and compressive mechanical properties of the natural and synthetic scaffolds were investigated and compared to that of natural cortical and cancellous bone. Prior to infiltration, the sintered cancellous scaffolds exhibited pore sizes of 100 – 300 μm, a strength of 0.4 – 9.7 MPa, and a Young’s modulus of 0.1 – 1.2 GPa. The freeze-casted scaffolds had pore sizes of 10 – 50 μm, strengths of 0.7 – 95.1 MPa, and Young’s moduli of 0.1 –19.2 GPa. When infiltrated with PMMA, the cancellous bone- PMMA composite showed a strength of 55 MPa and a Young’s modulus of 4.5 GPa. Preliminary data for the synthetic HA-PMMA composite showed a strength of 42 MPa and a modulus of 0.8 GPa.
Confidence intervals for the duration of a mass extinction
Authors: Wang Steve C. , Zimmerman Aaron E. , McVeigh Brendan S. , Everson Philip J. , Wong Heidi 
Published: March 2012

A key question in studies of mass extinctions is whether the extinction was a sudden or gradual event. This question may be addressed by examining the locations of fossil occurrences in a stratigraphic section. However, the fossil record can be consistent with both sudden and gradual extinctions. Rather than being limited to rejecting or not rejecting a particular scenario, ideally we should estimate therangeof extinction scenarios that is consistent with the fossil record. In other words, rather than testing the simplified distinction of “sudden versus gradual,” we should be asking, “How gradual?”In this paper we answer the question “How gradual could the extinction have been?” by developing a confidence interval for the duration of a mass extinction. We define the duration of the extinction as the time or stratigraphic thickness between the first and last taxon to go extinct, which we denote by Δ. For example, we would like to be able to say with 90% confidence that the extinction took place over a duration of 0.3 to 1.1 million years, or 24 to 57 meters of stratigraphic thickness. Our method does not deny the possibility of a truly simultaneous extinction; rather, in this framework, a simultaneous extinction is one whose value of Δ is equal to zero years or meters.We present an algorithm to derive such estimates and show that it produces valid confidence intervals. We illustrate its use with data from Late Permian ostracodes from Meishan, China, and Late Cretaceous ammonites from Seymour Island, Antarctica.
Communicating HSE to a New Generation
Authors: López Juan Carlos 
Published: April 2012

Abstract
Traditional means of communicating health, safety and environment (HSE) issues to a company workforce include alerts explaining accidents, stand-downs, magazines, celebrations, award ceremonies and HSE notice boards. The author values such tools, but believes their effectiveness can be limited, particularly in working environments that often involve employees of a wide diversity of cultures, languages and backgrounds. The author also considers that companies would benefit from adapting their communication strategies to mechanisms such as blogs, interactive video clips, and games, which are routinely used by, and are popular with, new generations of employees.
This paper describes initiatives implemented in an oilfield services company and the results, and concludes with proposed recommendations to improve the effectiveness of HSE communications to field employees. The main conclusion is that the more involved employees feel the more chance there is to learn from the message. In addition, no communication tool can replace the power of a manager taking the time to have face-to-face open and honest discussions with employees.