bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blood transfusions and the subsequent risk of hematologic malignancies
Authors: Chang Cindy M. , Quinlan Scott C. , Warren Joan L. , Engels Eric A. 
Published: May 2010

BACKGROUND: Blood transfusions are associated with viral transmission and immunomodulation, perhaps increasing subsequent risk of hematologic malignancies (HMs). Prior studies of transfusion recipients have lacked details on specific HM subtypes.STUDY DESIGN AND METHODS: Risk of HM after blood transfusion was evaluated in a US population‐based case‐control study (77,488 elderly HM cases identified through cancer registries, 154,509 controls). Transfusions were identified using linked Medicare hospitalization claims. Polytomous logistic regression was used to calculate odds ratios (ORs) associating transfusion and HM subtypes by features suggestive of a causal relationship.RESULTS: A history of transfusion was present in 7.9% of HM cases versus 5.9% of controls. Associations for most HM subtypes suggested reverse causality: ORs were elevated only during the shortest latency periods; ORs for unspecified anemia and gastrointestinal bleeding, which may be related to undiagnosed HM, were stronger than for surgeries, which are unlikely to be related to HM; and/or there was no dose response. In contrast, risk for lymphoplasmacytic lymphoma (1397 cases) was elevated at long latency (OR, 1.56 at 10+ years after transfusion), after transfusions related to surgeries (OR, 1.22‐1.47), and in a dose‐response relationship with number of transfusion‐related hospitalizations (OR, 1.53 with one hospitalization; OR, 1.80 with two or more hospitalizations, p trend < 0.0001). Risk for marginal zone lymphoma (1915 cases) was also elevated at 10+ years after transfusion (OR, 1.80).CONCLUSION: Consistent with prior studies, blood transfusions did not increase risk of most HM subtypes. Patterns of elevated risk for lymphoplasmacytic and marginal zone lymphomas suggest an etiologic role for transfusion.
A large number of mature and functional dendritic cells can be efficiently generated from umbilical cord blood–derived mononuclear cells by a simple two‐step culture method
Authors: Balan Sreekumar , Kale Vaijayanti P. , Limaye Lalita S. 
Published: May 2010

BACKGROUND: Advances in the past two decades in dendritic cell (DC) biology paved the way to exploit them as a promising tool in cancer immunotherapy. The prerequisite for DC vaccine preparations is large‐scale in vitro generations of homogeneous, mature, and functional DCs. Frequent improvements are being made in the existing in vitro DC production protocols to achieve this goal. In our previous study we reported a large‐scale generation of mature, functional DCs from umbilical cord blood (UCB) CD34+ cells. Here we report that this method can be used for the efficient generation of DCs from UCB mononuclear cells (MNCs) and thus the hematopoietic stem cell isolation step is not essential.STUDY DESIGN AND METHODS: MNCs or CD34+ cells isolated from the same cord blood (CB) samples were used for the generation of DCs. DCs were characterized for morphology, phenotype, and functional assays including antigen uptake, chemotaxis, and mixed leukocyte reaction. Similarly DCs generated from the MNCs of same fresh and frozen CB units were compared.RESULTS: The morphologic, phenotypic, and functional characterization of the DCs generated from various sets show that they were comparable in nature irrespective of the starting population used.CONCLUSION: We conclude that the CD34+ isolation step is not essential for the generation of mature, functional DCs and thus can be eliminated. More importantly, we show that DCs can be generated with equal efficiency from the MNCs of frozen CB units. Our culture method will be useful for exploiting the potential of UCB as an additional source for allogeneic DCs in the clinical settings.
Long‐Term Outcome of Atrial Fibrillation Ablation: Impact and Predictors of Very Late Recurrence
Authors: WOKHLU ANITA , HODGE DAVID O. , MONAHAN KRISTI H. , ASIRVATHAM SAMUEL J. , FRIEDMAN PAUL A. , MUNGER THOMAS M. , CHA YONG‐MEI , SHEN WIN‐KUANG , BRADY PETER A. , BLUHM CHRISTINE M. , HAROLDSON JANIS M. , HAMMILL STEPHEN C. , PACKER DOUGLAS L. 
Published: May 2010

Long‐Term Outcome of AF Ablation. Introduction: Ablation eliminates atrial fibrillation (AF) in studies with 1 year follow‐up, but very late recurrences may compromise long‐term efficacy. In a large cohort, we sought to describe the determinants of delayed recurrence after AF ablation.
Methods and Results: Seven hundred and seventy‐four patients with AF (428 paroxysmal [PAF, 55%] and 346 persistent or longstanding persistent [PersAF, 45%]) underwent wide area circumferential ablation (WACA, 62%) or pulmonary vein isolation (38%). Over 3.0 ± 1.9 years, there were 135 recurrences in PAF patients and 142 in PersAF patients. AF elimination was achieved in 61% of patients with PersAF at 2 years after last ablation and in 71% of patients with PAF (P = 0.04). This finding was related to a higher initial rate of very late recurrence in PersAF. From 1.0 to 2.5 years, the recurrence increased by 20% (from 37% to 57%) in PersAF patients versus only 12% (from 27% to 39%) in PAF patients. Independent predictors of overall recurrence included diabetes (HR 1.9 [1.3–2.9], P = 0.002) and PersAF (HR 1.6 [1.2–2.0], P < 0.001). Independent predictors of very late recurrence included PersAF (HR 1.7 [1.1–2.7], P = 0.018) and WACA (HR 1.8 [1.1–2.7], P = 0.018), while diabetes came close to significance. In PAF patients, left atrial size >45 mm was identified as an AF‐type specific predictor (HR 2.4 [1.3–4.7], P = 0.009), whereas in PersAF patients, no unique predictors were identified.
Conclusion: Late recurrences reduced the long‐term efficacy of AF ablation, particularly in patients with PersAF and underlying cardiovascular diseases. (J Cardiovasc Electrophysiol, Vol. 21, pp. 1071‐1078)
Predictors of Poor Outcome in Female Patients Undergoing Endovascular Intervention
Authors: ABBAS AMR E. , GOODMAN LAURA M. , TIMMIS RYAN , BOURA JUDITH 
Published: May 2010

Background:
Peripheral arterial disease (PAD) is widely accepted as an independent predictor of cardiovascular morbidity and mortality. The majority of subjects studied in PAD literature have been male, leaving female patients an underrepresented population with regard to revascularization outcomes and prognosis. The purpose of our study was to determine predictors of poor outcomes in female patients undergoing endovascular intervention (EI) for symptomatic PAD.
Methods:
This study was conducted as a single‐center retrospective chart review of 292 consecutive female patients who underwent EI for symptomatic PAD. Patient variables including baseline demographics, and procedural data were analyzed for statistical significance with regard to repeat EI including target vessel revascularization (TVR), amputation or vascular surgery, and death.
Results:
On multivariate analysis, increased preintervention creatinine ≥1.5 mg/dL (PRE‐CR) and lower preprocedure hemoglobin were the strongest predictors of subsequent EI and TVR. Significant predictors for amputation or surgery included decreased body mass index (BMI) and increased Rutherford class at presentation. Only age, history of congestive heart failure (CHF), and PRE‐CR remained significant predictors of mortality.
Conclusions:
Our study is the first of its kind to specify predictors of poor outcomes after EI in female patients with symptomatic PAD. The strongest predictors of subsequent EI and TVR, limb loss, and vascular surgery, as well as death, were found to be chronic kidney disease (CKD; PRE‐CR > 1.5 mg/dL), decreased BMI, Rutherford class, and anemia. (J Interven Cardiol 2010;23:401–410)
Diferencias de satisfacción con el trabajo en Europa según nivel salarial
Authors: POULIAKAS Konstantinos , THEODOSSIOU Ioannis 
Published: May 2010

Resumen.Los datos de seis olas (1996–2001) del Panel de Hogares de la Unión Europea (PHOGUE) indican que los trabajadores que cobran salarios bajos están mucho menos contentos que los que perciben una remuneración alta en el sur de Europa, si bien no ocurre lo mismo en los países del norte. Los empleos europeos de remuneración modesta no son forzosamente malos, aunque sí lo son en algunos países donde un sector de los trabajadores sufre de lleno el doble infortunio del trabajo mediocre con salario bajo. Las diferencias nacionales obedecen a las características propias de la transacción entre flexibilidad y seguridad, por lo que es esencial impulsar políticas que mejoren la calidad del trabajo.
Costos empresariales y reglamentación del trabajo en Sudáfrica
Authors: BENJAMIN Paul , BHORAT Haroon , CHEADLE Halton 
Published: May 2010

Resumen.Los indicadores de las normas laborales publicados en el estudio del Banco Mundial Doing Business 2007 son ambiguos sobre la naturaleza e intensidad de la reglamentación del trabajo en Sudáfrica. Estos indicadores, al centrarse exclusivamente en la legislación, dan una imagen parcial, por lo que los autores exploran tres posibles elementos para ampliarlos con miras a trazar un panorama más realista de la situación normativa del mundo del trabajo: la «microlegislación», las instituciones la‐borales y la interpretación judicial. Abogan por que se tengan muy presentes estos elementos al valorar el ordenamiento laboral.
La legalización del trabajo eventual realizada en Hungría
Authors: Tésits Róbert , Szenoradszki Endre 
Published: May 2010

Resumen.Hungría promulgó en 1997 la Ley del Trabajo Eventual con el fin de formalizar este régimen de empleo y simplificar los procedimientos administrativos. A su amparo se producían muchos abusos, pese a lo cual esta norma flexible se amplió en 2002 de los empleadores individuales a todas las empresas, elevándose el número de días anuales autorizados, rebajándose drásticamente las cotizaciones a la seguridad social y dando bonificaciones fiscales cuantiosas. El objetivo pasó a ser reducir el desempleo y el trabajo ilegal ampliando las fronteras del empleo «legal» o «regular», pero no se consiguieron buenos resultados. Al contrario, se ha ahondado considerablemente la vulnerabilidad de los trabajadores.
Agricultural trade and poverty in Chile: a spatial analysis of product tradability
Authors: Fleming David A. , Abler David G. , Goetz Stephan J. 
Published: May 2010

AbstractMany questions have arisen about the relationship between international agricultural trade and poverty in developing countries. This article explores these questions by analyzing local agricultural tradability indices, which measure the degree to which commodities produced in a particular region are traded internationally. Data are examined for Chile, a middle‐income country with a history of international agricultural trade over the last decades. Empirical results indicate that a higher agricultural tradability index is associated with lower poverty rates across Chilean comunas.
Using choice experiments to estimate consumer valuation: the role of experimental design and attribute information loads
Authors: Gao Zhifeng , House Lisa O. , Yu Xiaohua 
Published: May 2010

AbstractWith fixed dimensionality of choice experiments (CEs), previous simulation results show that D‐optimal design with correct a priori information generates more accurate valuation. In the absence of a priori information, random designs and designs incorporate attribute interactions result in more precise valuation estimates. In this article, Monte Carlo simulations demonstrate that the performances of different design strategies are affected by attribute information loads in CEs. Consumer valuation estimates in simulation settings vary with the number of attributes.
10‐Year trends in the treatment and outcomes of patients with first‐episode schizophrenia
Authors: Nielsen J. , Le Quach P. , Emborg C. , Foldager L. , Correll C. U. 
Published: May 2010

Nielsen J, le Quach P, Emborg C, Foldager L, Correll CU. 10‐Year trends in the treatment and outcomes of patients with first‐episode schizophrenia.Objective:  The first episode of schizophrenia is a critical period for illness course and outcomes. We aimed to investigate treatments and outcomes during the first year after the diagnosis of schizophrenia.Method:  Pharmacoepidemiologic inception cohort study of all newly diagnosed patients with schizophrenia in Denmark (n = 13 600) 1996–2005.Results:  From 1996 to 2005, the mean age at first diagnosis decreased significantly (29.2–26.1 years), more patients received antipsychotics (67.2–80.7%, annual OR = 1.07, CI: 1.06–1.09, P < 0.001) and antipsychotic polypharmacy for >4 months (16.7–37.1%, OR = 1.14, CI: 1.12–1.57, P < 0.001). The antipsychotic defined daily dosage (DDD) doubled (150–332 DDD, P < 0.001), use of antidepressants (24.3–40.6%, P < 0.001). Bed days [89.9 days (CI: 81.8–98.8) to 71.8 days, CI: 63.7–80.8, P < 0.0001] decreased, whereas outpatient contacts [10.2 (CI: 9.5–11.0) to 21.4 (CI: 19.9–21.0), P < 0.0001] doubled.Conclusion:  Between 1996 and 2005, there was an earlier recognition of schizophrenia, intensified outpatient treatment, increased use and dosing of antipsychotics and antidepressants, but also more antipsychotic polypharmacy.
Clinical follow‐up of unilateral, fixed dental prosthesis on maxillary implants
Authors: Wahlström Monica , Sagulin Gun‐Britt , Jansson Leif E. 
Published: May 2010

AbstractAims/Background: The aims of the present study were to evaluate (1) the success rate of unilateral maxillary fixed dental prosthesis (FDPs) on implants in patients at a periodontal clinic referred for periodontal treatment, (2) the prevalence of varying mechanical and biological complications and (3) effects of potential risk factors on the success rate.Material and methods: Fifty consecutive patients were invited to participate in a follow‐up. The patients had received FDPs on implants between November 2000 and December 2003 after treatment to achieve optimal peridontal health, and the FDPs had been in function for at least 3 years. A questionnaire was sent to the patients before the follow‐up examination. Forty‐six patients with 116 implants were examined. The follow‐up comprised clinical and radiographic examinations and evaluations of treatment outcome.Results: Before implant treatment, 13% of the teeth were extracted; of these, 80% were extracted due to periodontal disease. No implants had been lost before implant loading. One implant in one patient fractured after 3 years of functional loading and three implants in another patient after 6.5 years. The most frequent mechanical complications were veneer fractures and loose bridge screws. Patients with peri‐implant mucositis had significantly more bleeding on probing around teeth and implants. Patients with peri‐implantitis at the follow‐up had more deep periodontal pockets around their remaining teeth compared with individuals without peri‐implantitis, but these differences were not significant. Smokers had significantly fewer teeth, more periodontal pockets ≥4 mm and a tendency towards greater marginal bone loss at the follow‐up, compared with non‐smokers.Conclusion: In the short term, overloading and bruxism seem more hazardous for implant treatment, compared with a history of periodontitis. To cite this article:
Wahlström M, Sagulin G‐B, Jansson LE. Clinical follow‐up of unilateral, fixed dental prosthesis on maxillary implants Clin. Oral Impl. Res. 21, 2010; 1294–1300. doi: 10.1111/j.1600‐0501.2010.01948.x
An animal model for sinus floor elevation with great elevation heights. Macroscopic, microscopic, radiological and micro‐CT analysis: ex vivo
Authors: Stelzle Florian , Benner Klaus‐Ulrich 
Published: May 2010

AbstractObjectives: Different animal models are used for research and training concerning sinus floor elevation. However, there is little information regarding an animal model for elevation heights of approximately 10 mm. The aim of this study was to explore the anatomical aspects of the maxillary sinus of adult pigs and to investigate the suitability of this animal as a model for sinus floor elevation training and research with great elevation heights.Material and methods: Thirty‐four bisected heads of adult domestic pigs were examined 6 h postmortem. Direct sinus floor elevation was performed with an elevation height of 10 mm. Localization, diameters, volume and septa of the maxillary sinus were recorded on lateral X‐rays and macroscopically. The thickness and structure of the maxillary sinus were investigated microscopically. The osseous microstructure of the lateral sinus wall was assessed microscopically and via micro‐CT.Results: The maxillary sinus of the adult pig exhibits an average length of 51±6.2 mm, a height of 31±4.1 mm, a width of 19±1.6 mm and a volume of 31±7.6 cm3. At least one septum could be observed on the floor of each sinus. The mucosal thickness amounted to a mean of 1692±138 μm, and the lateral bony wall of the sinus to a mean of 3±0.3 mm. A laceration of the Schneiderian membrane occurred in 25% during the elevation process.Conclusion: The maxillary sinus of adult domestic pigs is a suitable model for sinus floor elevation training and research with greater elevation heights of up to 10 mm. To cite this article:
Stelzle F, Benner K‐U. An animal model for sinus floor elevation with great elevation heights. Macroscopic, microscopic, radiological and micro‐CT analysis: ex vivo. Clin. Oral Impl. Res. 21, 2010; 1370–1378. doi: 10.1111/j.1600‐0501.2010.01958.x
Periodontal infection and subclinical atherosclerosis: the role of high‐density lipoprotein as a modifying factor
Authors: Ylöstalo Pekka , Anttila Sirpa , Rajala Ulla , Päivänsalo Markku , Keinänen‐Kiukaanniemi Sirkka , Sakki Tero , Knuuttila Matti 
Published: May 2010

Ylöstalo P, Anttila S, Rajala U, Päivänsalo M, Keinänen‐Kiukaanniemi S, Sakki T, Knuuttila M. Periodontal infection and subclinical atherosclerosis: the role of high‐density lipoprotein as a modifying factor. J Clin Periodontol 2010; 37: 617–624. doi: 10.1111/j.1600‐051X.2010.01572.x.AbstractBackground: Periodontitis is suggested to enhance the process of vascular inflammation leading to atherosclerosis. The purpose was to study the relation between periodontal infection and subclinical atherosclerosis, and whether this relation is dependent on high‐density lipoprotein (HDL) cholesterol levels.Methods: A secondary analysis of the data of a diabetic study, confined to 60 dentate subjects who underwent clinical examinations in 1990–1992 and in 1996–1998, was carried out. Ultrasonographic measurements of carotid, aortic and femoral atherosclerosis were performed in 2000.Results: No consistent association was found between the presence of periodontal pockets and subclinical atherosclerosis in the total population, but a fairly strong association was found among subjects with a low HDL level, whereas in subjects with a high HDL level, an opposing and less consistent association was found. Product terms indicating a possible modification by HDL were statistically significant (at p=0.05 level) for total plaques with all cut‐off values, for plaques in carotid arteries with cut‐off values 1.2–1.4 and for intima‐media thickness with cut‐off values of 1.1–1.2, but not for aorta plaques.Conclusions: HDL levels or factors closely associated with HDL levels appear to modify the association between periodontal infection and certain parameters of subclinical atherosclerosis.
Interleukin‐1β levels in gingival crevicular fluid and serum under naturally occurring and experimentally induced gingivitis
Authors: Trombelli Leonardo , Scapoli Chiara , Carrieri Alberto , Giovannini Gloria , Calura Giorgio , Farina Roberto 
Published: May 2010

Trombelli L, Scapoli C, Carrieri A, Giovannini G, Calura G, Farina R. Interleukin‐1β levels in gingival crevicular fluid and serum under naturally occurring and experimentally induced gingivitis. J Clin Periodontol 2010; 37: 697‐704 doi: 10.1111/j.1600-051X.2010.01573.x.AbstractAims: To evaluate the interleukin‐1β (IL‐1β) levels in gingival crevicular fluid (GCF) and serum in either naturally occurring (N‐O) or experimentally induced (E‐I) plaque‐associated gingivitis.Material and Methods: Thirty‐seven periodontally healthy subjects were evaluated in real life conditions (N‐O gingivitis) as well as after 21 days of experimental gingivitis trial (E‐I gingivitis). During the experimental gingivitis trial, in one maxillary quadrant (test quadrant), gingival inflammation was induced by oral hygiene abstention, while in the contralateral (control) quadrant, oral hygiene was routinely continued. IL‐1β concentrations in N‐O and E‐I gingivitis were investigated for IL‐1B+3954 and IL‐1B−511 gene polymorphisms.Results: (i) GCF IL‐1β concentrations in E‐I gingivitis were significantly higher compared with N‐O gingivitis; (ii) an intra‐individual correlation between GCF concentrations of IL‐1β detected in N‐O and E‐I gingivitis was observed in control quadrants, but not in test quadrants; (iii) IL‐1β concentration in GCF was associated with IL‐1B+3954 genotype only at test quadrants; (iv) IL‐1β was detectable in serum only at low levels in a limited number of subjects, without difference between gingivitis conditions.Conclusions: Aspects of the bacterial challenge to the gingival tissues, such as the amount of plaque deposits and plaque accumulation rate, appear to affect the IL‐1β levels in GCF in subjects with a specific IL‐1B genotype.