bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Computer-based Clinical Decision Support Systems and Content for Diabetes Mellitus
Authors: Wright A. , Burton M. , Fraser G. , Krall M. , Maviglia S. , Mohammed-Rajput N. , Simonaitis L. , Sonnenberg F. , Middleton B. , Kantor M. 
Published: August 2011

SummaryBackground: Computer-based clinical decision support (CDS) systems have been shown to improve quality of care and workflow efficiency, and health care reform legislation relies on electronic health records and CDS systems to improve the cost and quality of health care in the United States; however, the heterogeneity of CDS content and infrastructure of CDS systems across sites is not well known.Objective: We aimed to determine the scope of CDS content in diabetes care at six sites, assess the capabilities of CDS in use at these sites, characterize the scope of CDS infrastructure at these sites, and determine how the sites use CDS beyond individual patient care in order to identify characteristics of CDS systems and content that have been successfully implemented in diabetes care.Methods: We compared CDS systems in six collaborating sites of the Clinical Decision Support Consortium. We gathered CDS content on care for patients with diabetes mellitus and surveyed institutions on characteristics of their site, the infrastructure of CDS at these sites, and the capabilities of CDS at these sites.Results: The approach to CDS and the characteristics of CDS content varied among sites. Some commonalities included providing customizability by role or user, applying sophisticated exclusion criteria, and using CDS automatically at the time of decision-making. Many messages were actionable recommendations. Most sites had monitoring rules (e.g. assessing hemoglobin A1c), but few had rules to diagnose diabetes or suggest specific treatments. All sites had numerous prevention rules including reminders for providing eye examinations, influenza vaccines, lipid screenings, nephropathy screenings, and pneumococcal vaccines.Conclusion: Computer-based CDS systems vary widely across sites in content and scope, but both institution-created and purchased systems had many similar features and functionality, such as integration of alerts and reminders into the decision-making workflow of the provider and providing messages that are actionable recommendations.
C2‐Symmetrical Bipyridyldiols as Promising Enantioselective Catalysts in Nozaki–Hiyama Allylation
Authors: Huang Xin‐Ren , Pan Xin‐Hong , Lee Gene‐Hsian , Chen Chinpiao 
Published: August 2011

AbstractSeveral new chiral bipyridyldiol ligands that promote the chromium‐catalyzed enantioselective addition of allylic halides to aldehydes in up to 99% ee were synthesized. The chromium‐catalyzed allylation of aldehydes using ligands 4 and 4a in the presence of chromium(III) chloride and allyl chloride provided the highest enantioselectivity.
Rhodium‐Catalyzed Allylation of Benzyl Acetates with Allylsilanes
Authors: Onodera Gen , Yamamoto Eriko , Tonegawa Shota , Iezumi Makoto , Takeuchi Ryo 
Published: August 2011

AbstractBenzyl acetate reacted with allyltrimethylsilane to give an allylation product in the presence of a catalytic amount of the (cyclooctadiene)rhodium(I) chloride dimer {[Rh(cod)Cl]2}, sodium tetrakis[3,5‐bis(trifluoromethyl)phenyl]borate (NaBARF), and triphenyl phosphite [P(OPh)3] in refluxing 1,2‐dichloroethane. Primary, secondary and tertiary benzyl acetates could be used for the reaction. Moreover, allylation of gem‐benzyl acetate was possible with [Rh(cod)Cl]2, NaBARF, and P(OPh)3. Monoallylation and diallylation of gem‐benzyl acetate could be controlled by altering the reaction conditions. Cationic rhodium species generated in situ act as a Lewis acid catalyst to give a benzyl carbocation by elimination of the acetoxy group from the benzylic carbon.
Synthesis of α‐Hydroxy Carboxylic Acids via a Nickel(II)‐ Catalyzed Hydrogen Transfer Process
Authors: Tang Guo , Cheng Chien‐Hong 
Published: August 2011

AbstractA new catalytic system for β‐alkylation of lactic acid with primary alcohols has been developed. In the presence of nickel(II) acetate tetrahydrate [Ni(OAc)2(H2O)4] and base, lactic acid reacts with primary alcohols to afford the corresponding coupled α‐hydroxy carboxylic acids in good to excellent yields via a hydrogen transfer process without any hydrogen acceptor or hydrogen donor.
Desymmetrization of meso‐Glycerol Derivatives Induced by L‐Histidine‐Derived Acylation Catalysts
Authors: Sakakura Akira , Umemura Shuhei , Ishihara Kazuaki 
Published: August 2011

AbstractThe desymmetrization of meso‐glycerol derivatives bearing a 3‐pyrroline‐1‐carbonyl (Pyroc) directing group is demonstrated through an enantioselective acylation reaction promoted by L‐histidine‐derived bifunctional catalysts. The desired monoacylated products are obtained in good yields (up to 74%) with high enantioselectivities (up to 99% ee).
Lewis Acid‐Mediated Acetal Substitution Reactions: Mechanism and Application to Asymmetric Catalysis
Authors: Kobayashi Shū , Arai Kenzo , Yamakawa Takeshi , Chen Yi‐Jing , Salter Matthew M. , Yamashita Yasuhiro 
Published: August 2011

AbstractSubstitution reactions of acetals with carbon nucleophiles are fundamental and conventional organic reactions. We succeeded in the preparation of an optically active acetal, which reacted with a silyl enol ether smoothly to afford the desired adducts in racemic forms. By comparison of the ees of the products with the ees of the recovered acetals, we concluded that the aldol‐type reactions proceeded not via direct displacement (SN2) or contact ion pairs (intimate ion pair) (SN1) but by a free oxocarbenium ion (SN1) mechanism. Next, a study to achieve asymmetric catalysis of the acetal substitution reactions was conducted. After many trials, it was found that a chiral niobium complex prepared from pentamethoxyniobium [Nb(OMe)5] and a tetradentate BINOL derivative could achieve high enantioselectivities. Asymmetric aldol‐type reactions of acetals with silyl enol ethers proceeded smoothly to afford the corresponding aldol‐type adducts in good yields with high enantioselectivities.
Subtelomeric monosomy 11q and trisomy 16q in siblings and an unrelated child: Molecular characterization of two der(11)t(11;16)
Authors: Basinko Audrey , Audebert‐Bellanger Séverine , Douet‐Guilbert Nathalie , Le Franc Jérémie , Parent Philippe , Quemener Sylvia , La Selve Philippe , Bovo Clément , Morel Frédéric , Le Bris Marie‐Josée , De Braekeleer Marc 
Published: August 2011

AbstractWe report here three children with a der(11)t(11;16), two sibs (patients 1 and 2) having inherited a recombinant chromosome from a maternal t(11;16)(q24.3;q23.2) and a third unrelated child with a de novo der(11)t(11;16)(q25;q22.1), leading to partial monosomy 11q and trisomy 16q. Fluorescent in situ hybridization (FISH) using bacterial artificial chromosome (BAC) clones and array‐CGH were performed to determine the breakpoints involved in the familial and the de novo rearrangements. The partial 11 monosomy extended from 11q24.3 to 11qter and measured 6.17–6.21 Mb in Patients 1 and 2 while the size of the partial 11q25‐>qter monosomy was estimated at 1.97–2.11 Mb for Patient 3. The partial 16 trisomy extended from 16q23.2 to 16qter and measured 8.93–8.95 Mb in Patients 1 and 2 while the size of the partial 16q22.1‐>qter trisomy was 20.82 Mb for Patient 3. Intraventricular hemorrhage and transitional thrombocytopenia were found in both sibs but not in the third patient. The FLI1 gene, which is the most relevant gene for thrombocytopenia in Jacobsen syndrome, was neither deleted in family A nor in Patient 3. We suggest that a positional effect could affect the FLI1 expression for these two sibs. Deafness of our three patients confirmed the association of this anomaly to 11q monosomy and tended to confirm the hypothetic role of DFNB20 in Jacobsen syndrome hearing loss. Both sibs shared most of the features commonly observed in Jacobsen syndrome, but not the third patient. This confirmed that terminal 11q trisomy spanning 1 to 1.97–2.11 Mb is not associated with a typical Jacobsen syndrome. © 2011 Wiley‐Liss, Inc.
Preparation and properties of polyhedral oligomeric silsesquioxane polymers
Authors: Shioda Takahiro , Gunji Takahiro , Abe Noritaka , Abe Yoshimoto 
Published: August 2011

AbstractPolyhedral oligomeric silsesquioxane (POSS) polymers were synthesized by the dehydrogenative condensation of (HSiO3/2)8 with water in the presence of diethylhydroxylamine followed by trimethylsilylation. Coating films were prepared by spin‐coating of the coating solution prepared by the dehydrogenative condensation of POSS. The hardness of the coating films was evaluated using a pencil‐hardness test and was found to increase up to 8H with increases in the curing temperature. Free‐standing film and silica gel powder were prepared by aging the coating solution at room temperature. The silica gel powder was subjected to heat treatment under air atmosphere to show a specific surface area of 440 m2 g−1 at 100 °C, which showed a maximum at 400 °C as 550 m2 g−1. Copyright © 2011 John Wiley & Sons, Ltd.
Carbon–carbon bond formation between secondary alcohols and aldehydes under ruthenium‐catalyzed redox shuttle
Authors: Cho Chan Sik , Kim Bok Tae , Yoon Nam Sik 
Published: August 2011

AbstractSecondary alcohols are coupled with aldehydes in dioxane in the presence of a catalytic amount of a ruthenium catalyst along with KOH to give coupled ketones or coupled secondary alcohols depending on the molar ratio of secondary alcohols to aldehydes and the presence (or absence) of a sacrificial hydrogen acceptor. Copyright © 2011 John Wiley & Sons, Ltd.
Copper(II) complexes of hydroxyflavone derivatives as potential bioactive molecule to combat antioxidants: synthesis, characterization and pharmacological activities
Authors: Nagashri K. , Joseph J. , Dhanaraj C. Justin 
Published: August 2011

AbstractA variety of novel copper complexes were synthesized and characterized of the formulae [Cu(L1)(OAc)], [CuL2(H2O)], [CuL3(H2O)], [CuL4(OAc)], [CuL5(H2O)] [CuL6], [CuL7], [CuL8](OAc) and [CuL9], where L1L9 represents Schiff base ligands [derived by the condensation of 5‐hydroxyflavone with 4‐aminoantipyrine (L1), o‐aminophenol (L2), o‐aminobenzoic acid (L3), o‐aminothiazole (L4), thiosemicarbazide (L5), 4‐aminoantipyrine‐o‐aminophenol (L6), 4‐aminoantipyrine‐o‐aminobenzoic acid (L7), 4‐aminoantipyrine‐o‐aminothiazole(L8) and 4‐aminoantipyrine‐thiosemicarbazide (L9)]. The spectral and magnetic results of the Cu(II) complexes exhibit square planar geometry. The DNA binding properties of copper complexes were studied by using electronic absorption spectra, viscosity and thermal denaturation experiments. The results show that the complexes were interacting with calf thymus (CT DNA). The in vitro antimicrobial activities of the investigated compounds were tested against the bacterial species and fungal species. Superoxide dismutase and antioxidant activities of the copper complexes have also been studied. Copyright © 2011 John Wiley & Sons, Ltd.
Effect of nucleating agents on the molar mass distribution and its correlation with the isothermal crystallization behavior of poly(L‐lactic acid)
Authors: Penco Maurizio , Spagnoli Gloria , Peroni Isabella , Rahman M. Arifur , Frediani Marco , Oberhauser Werner , Lazzeri Andrea 
Published: August 2011

AbstractIn this work, the effect of the processing conditions on the thermal behavior of a commercial poly(L‐lactic acid) (PLLA) was investigated. In particular, PLLA having a very high molecular weight was processed by a discontinuous mixer at different mixing conditions. The molar mass variation was investigated by size exclusion chromatography–multiangle laser light scattering chromatography, and the thermal characteristics were detected by the conventional differential scanning calorimetry and dynamic mechanical thermal analysis. Tensile tests were performed at room temperature and at 60°C. Our attention was essentially focused on the crystallization behavior of the various samples obtained. A modest decline in the molar mass was obtained with two mixing temperatures of 210 and 250°C, but a significant increase in the crystalline phase content was noticed, with a concomitant tremendous increment in the crystallization rate. A correlation was also made between the molar mass distribution and crystallization rate in isothermal conditions, where clearly visible were the effects of the processing temperature on both the molar mass distribution and how the nucleating agents affected the crystallinity of PLLA. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Mechanical properties of injection‐molded binary blends of polyethylene with small additions of a liquid‐crystalline polymer
Authors: Ivanova Tatjana , Zicans Janis , Elksnite Ilze , Kalnins Martins , Maksimov Robert 
Published: August 2011

AbstractThe results of the investigation of the mechanical properties of polyethylene (PE) blends with small (<3 wt %) additions of thermotropic liquid‐crystalline polymers (LCPs) are reported. PE/LCP compositions with various LCP weight contents were obtained by thermoplastic mixing in a two‐stage process. Short‐term and long‐term mechanical behavior of various PE/LCP compositions were analyzed. Data on the influence of LCP addition on the tensile elastic modulus [or Young's modulus (E)], stress at yield (σY), stress at break (σB), strain at yield, strain at break, and deformation at long‐term (1000‐h) tensile creep were obtained. The experimental results of the investigation show that even small additions of LCP allowed considerable increases in E, σY, σB, and creep resistance of PE. To support the experimental data, we mathematically analyzed the elastic properties of the materials by taking into account the effect of self‐reinforcement due to the formation of extended LCP inclusions. The results of the theoretical analysis testify that LCP inclusions in the continuous PE matrix were elongated 5–10 times because of their orientation during the manufacturing of the test specimens. Analytical descriptions of the creep of the PE/LCP blends are also presented. It is demonstrated that the creep behavior of the PE/LCP blends could be sufficiently well described by power law. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Risk and Prisoner's Dilemma: A Reinterpretation of Coombs' Re‐parameterization
Authors: Au Wing Tung , Lu Su , Leung Hildie , Yam Paton , Fung Jane M. Y. 
Published: August 2011

AbstractWe propose a model to measure risk in a prisoner's dilemma based on Coombs' (1973) re‐parameterization of the game as an individual risk decision‐making task that chooses between a gamble of cooperation and another gamble of defection. Specifically, we propose an index,r, to represent the risk associated with cooperation relative to defection. In conjunction with Rapoport's (1967) index of cooperation (K), our formulation of risk allows us to construct games that vary in risk (as indexed byr) while controlling for cooperativeness (as indexed byK). Following utility analysis that models risk seeking as a convex utility function and risk averse as a concave function, we predict that risk‐seeking people cooperate more in games that the cooperation choice is more risky, whereas risk‐averse people cooperate more in games that the cooperation choice is less risky. In the three studies that we varied game parameters, used different measures of risk orientation and prosocial orientation and used different experimental procedures, we found robust results supporting our predictions. Theoretical analysis of our formulation further suggests that risk and cooperativeness of a prisoner's dilemma game is not entirely independent. Games that have a higher cooperativeness index are necessarily more risky. Copyright © 2011 John Wiley & Sons, Ltd.
The genous™ endothelial progenitor cell capture stent accelerates stent re‐endothelialization but does not affect intimal hyperplasia in porcine coronary arteries
Authors: van Beusekom Heleen M.M. , Ertaş Gökhan , Sorop Oana , Serruys Patrick W. , van der Giessen Willem J. 
Published: August 2011

AbstractObjectives: To study the effect of endothelial progenitor cell (EPC) capture on the vascular response to coronary stenting. Background: The introduction of drug‐eluting stents has reduced the need for target lesion revascularization, but their effect on delayed healing, inflammation, and vascular dysfunction has emphasized the need to design strategies that improve current DES. One such strategy is to improve endothelialization by capturing CD34‐positive cells (EPC) by the stent surface. The first human clinical trial using coronary EPC capture stents showed stent safety but neointimal thickness (NIT) was not reduced compared to bare metal stents (BMS). To understand these responses we studied the coronary response to the EPC capture stent in swine. Methods and Results: The stent, coated with murine antihuman monoclonal CD34 antibodies, was assessed with QCA guided stent implantation in normal swine coronary arteries for early endothelialization at 2 and 5 days, and NIT at 28 and 90 days in comparison to control stents carrying a non‐specific murine antibody or to BMS. The main finding was that while the EPC capture stent significantly improved early endothelialization it did not reduce NIT at 28 and 90 days. Conclusions: The EPC capture stent improves early endothelialization in swine but this does not affect neointimal thickness as compared to control stents at 28 and 90 days. © 2011 Wiley Periodicals, Inc.
Chiroptical Nanofibers Generated from Achiral Metallophthalocyanines Induced by Diamine Homochirality
Authors: Zhang Wei , Fujiki Michiya , Zhu Xiulin 
Published: August 2011

AbstractOptically active cofacial π–π phthalocyanine (Pc) stacked supramolecules were spontaneously and successfully generated from a mixture of four possible geometric isomers (C4h, D2h, C2v, Cs) of achiral 4(5),4′(5′),4′′(5′′),4′′′(5′′′)‐tetracarboxymetallophthalocyanine (tcPcM; M=Ni, Cu) induced by an equimolar amount of inexpensive chiral diamine molecular sources in DMSO/CHCl3 mixed solvent under optimized conditions of the volume ratio of poor/good cosolvents, the molar ratio of chiral molecular diamine to tcPcM, the cavity metal of phthalocyanine, and the addition order of the amines. The sign and amplitude of circular dichroism spectra due to the supramolecular chirality and structure of the diamine molecules are impossible to remove by additions of the antipode diamine and trifluoroacetic acid. The chiral diamine was partly contained in nanofibers, and that retained in the solution can be recycled and reused to induce optically active tcPcM supramolecules.
Thiodiacetate–Manganese Chemistry with N ligands: Unique Control of the Supramolecular Arrangement over the Metal Coordination Mode
Authors: Grirrane Abdessamad , Pastor Antonio , Galindo Agustín , Álvarez Eleuterio , Mealli Carlo , Ienco Andrea , Orlandini Annabella , Rosa Patrick , Caneschi Andrea , Barra Anne‐Laure , Sanz Javier Fernández 
Published: August 2011

AbstractCompounds based on the Mn–tda unit (tda=S(CH2COO)2−2) and N co‐ligands have been analyzed in terms of structural, spectroscopic, magnetic properties and DFT calculations. The precursors [Mn(tda)(H2O)]n (1) and [Mn(tda)(H2O)3]⋅H2O (2) have been characterized by powder and X‐ray diffraction, respectively. Their derivatives with bipyridyl‐type ligands have formulas [Mn(tda)(bipy)]n (3), [{Mn(N‐N)}2(μ‐H2O)(μ‐tda)2]n (N‐N=4,4′‐Me2bipy (4), 5,5′‐Me2bipy, (5)) and [Mn(tda){(MeO)2bipy}⋅2 H2O]n (6). Depending on the presence/position of substituents at bipy, the supramolecular arrangement can affect the metal coordination type. While all the complexes consist of 1D coordination polymers, only 3 has a copper–acetate core with local trigonal prismatic metal coordination. The presence of substituents in 4–6, together with water co‐ligands, reduces the supramolecular interactions and typical octahedral MnII ions are observed. The unicity of 3 is also supported by magnetic studies and by DFT calculations, which confirm that the unusual Mn coordination is a consequence of extended noncovalent interactions (π–π stacking) between bipy ligands. Moreover, 3 is an example of broken paradigm for supramolecular chemistry. In fact, the desired stereochemical properties are achieved by using rigid metal building blocks, whereas in 3 the accumulation of weak noncovalent interactions controls the metal geometry. Other N co‐ligands have also been reacted with 1 to give the compounds [Mn(tda)(phen)]2⋅6 H2O (7) (phen=1,10‐phenanthroline), [Mn(tda)(terpy)]n (8) (terpy=2,2′:6,2′′‐terpyridine), [Mn(tda)(pyterpy)]n (9) (pyterpy=4′‐(4‐pyridyl)‐2,2′:6,2′′‐terpyridine), [Mn(tda)(tpt)(H2O)]⋅2 H2O (10) and [Mn(tda)(tpt)(H2O)]2⋅2 H2O (11) (tpt=2,4,6‐tris(2‐pyridyl)‐1,3,5‐triazine). Their identified mono‐, bi‐ or polynuclear structures clearly indicate that hydrogen bonding is variously competitive with π–π stacking.
Delayed synapse elimination in mouse levator palpebrae superioris muscle
Authors: Fox Michael A. , Tapia Juan Carlos , Kasthuri Narayanan , Lichtman Jeff W. 
Published: August 2011

AbstractAt birth, synaptic sites in developing rodent muscles are innervated by numerous motor axons. During subsequent weeks, this multiple innervation disappears as one terminal strengthens, and all the others are eliminated. Experimental perturbations that alter neuromuscular activity affect the rate of synaptic refinement, with more activity accelerating the time to single innervation and neuromuscular blockade retarding it. However, it remains unclear whether patterns of muscle use (driven by endogenous neuronal activity) contribute to the rate of synapse elimination. For this reason we examined the timing of supernumerary nerve terminal elimination at synapses in extraocular muscles (EOMs), a specialized set of muscles controlling eye movements. On the basis of their exceptionally high patterns of activity, we hypothesized that synaptic refinement would be greatly accelerated at these synapses. We found, however, that rates of synaptic refinement were only modestly accelerated in rectus and oblique EOMs compared with synapses in somite‐derived skeletal muscle. In contrast to these results, we observed a dramatic delay in the elimination of supernumerary nerve terminals from synapses in the levator palpebrae superioris (LPS) muscle, a specialized EOM that initiates and maintains eyelid elevation. In mice, natural eye opening occurs at the end of the second postnatal week of development. Thus, although synapse elimination is occurring in most EOMs and somite‐derived skeletal muscles, it appears to be dramatically delayed in a set of specialized eyelid muscles that remain immobile during early postnatal development. J. Comp. Neurol. 519:2907‐2921, 2011. � 2011 Wiley‐Liss, Inc.