bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are you fun, funny and laughing? The friendships and social relationships of students with complex communication needs in and outside of special school settings
Authors: Ho Hui Jun , Kamenopoulou Leda , Pinto Cynthia 
Published: June 2024

AbstractFriendships and social relationships are central to wellbeing but the friendships of those with complex needs are often ignored. This study explored the friendships and social relationships of students with complex communication needs (CCN) in and outside of special school settings, to understand how they view and experience them. There were 20 participants—6 students, 8 of their parents and 6 of their teachers. The research was conducted in two stages: Stage 1 included semi‐structured interviews with adults and unstructured observations of students in class and at breaktimes. Stage 2 included working with students through a Mosaic approach, using six tools (pyramid ranking activity, preferred activity with friends cards, best friends activity, school tours, collections from home and book‐making). Transcripts of recordings were analysed using reflexive thematic analysis. The four themes generated highlight how students with CCN have more accurate views of their social lives than adults, students and adults have differing views about what makes a good friend, students with CCN find ways to enact meaningful social contact through a connection beyond words, and reciprocity in friendships means no distinction between ‘helper’ and ‘needing help’. Strengths and limitations are highlighted and implications for researchers and practitioners are discussed.
Assessment of urine drug screen utility at autopsy to predict laboratory postmortem blood toxicology
Authors: Arndt Crystal , Huestis Marilyn A. , Jarvis Hannah C. , Gray Teresa R. 
Published: June 2024

AbstractWhen faced with increasing drug‐related deaths and decline in practicing forensic pathologists, the need to quickly identify toxicology‐related deaths is evident in order to appropriately triage cases and expedite turnaround times. Lateral flow immunoassays conducted pre‐autopsy offer quick urine drug screen (UDS) results in minutes and are used to inform the need for autopsy. Over 1000 medicolegal cases were reviewed to compare UDS results to laboratory enzyme‐linked immunosorbent assay (ELISA) blood results to evaluate how well autopsy UDS predicted laboratory findings. Mass spectral analysis was performed on ELISA‐positive specimens and these data were used to investigate UDS false‐negative (FN) results when possible. Five different UDS devices (STAT One Step Drug of Abuse dip card and cassette, Premiere Biotech multi‐drug and fentanyl dip cards and ATTEST 6‐acetylmorphine (6‐AM) dip card) were tested encompassing 11 drug classes: 6‐AM, amphetamine/methamphetamine, benzodiazepines, benzoylecgonine, fentanyl, methadone, opioids, phencyclidine, and delta‐9‐tetrahydrocannabinol. Sensitivity, specificity, efficiency, and positive and negative predictive values >80% indicated that UDS was useful for predicting cases involving benzoylecgonine, methadone, methamphetamine, and phencyclidine. UDS was unreliable in predicting amphetamine, benzodiazepines, fentanyl, and opiates‐related cases due to a high percentage of FN (up to 11.2%, 8.0%, 12.4%, and 5.5%, respectively) when compared to ELISA blood results. For the later analytes, sensitivities were as low as 57.5%, 60.0%, 72.2%, and 66.7%, respectively. Overall results support that UDS cannot replace laboratory testing. Because UDS is subject to false‐positive and FN results users must understand the limitations of using UDS for triage or decision‐making purposes.
Orchidinae‐205: A new genome‐wide custom bait set for studying the evolution, systematics, and trade of terrestrial orchids
Authors: Veltman Margaretha A. , Anthoons Bastien , Schrøder‐Nielsen Audun , Gravendeel Barbara , de Boer Hugo J. 
Published: June 2024

AbstractTerrestrial orchids are a group of genetically understudied, yet culturally and economically important plants. The Orchidinae tribe contains many species that produce edible tubers that are used for the production of traditional delicacies collectively called ‘salep’. Overexploitation of wild orchids in the Eastern Mediterranean and Western Asia threatens to drive many of these species to extinction, but cost‐effective tools for monitoring their trade are currently lacking. Here we present a custom bait kit for target enrichment and sequencing of 205 novel genetic markers that are tailored to phylogenomic applications in Orchidinae s.l. A subset of 31 markers capture genes putatively involved in the production of glucomannan, a water‐soluble polysaccharide that gives salep its distinctive properties. We tested the kit on 73 taxa native to the area, demonstrating universally high locus recovery irrespective of species identity, that exceeds the total sequence length obtained with alternative kits currently available. Phylogenetic inference with concatenation and coalescent approaches was robust and showed high levels of support for most clades, including some which were previously unresolved. Resolution for hybridizing and recently radiated lineages remains difficult, but could be further improved by analysing multiple haplotypes and the non‐exonic sequences captured by our kit, with the promise to shed new light on the evolution of enigmatic taxa with a complex speciation history. Offering a step‐up from traditional barcoding and universal markers, the genome‐wide custom loci targeted by Orchidinae‐205 are a valuable new resource to study the evolution, systematics and trade of terrestrial orchids.
SpatMCDA: An R package for assessing areas at risk of infectious diseases based on spatial multi‐criteria decision analysis
Authors: Wang Haoran , Zeng Jiankai , Gao Xiang , Wang Hongbin , Xiao Jianhua 
Published: June 2024

Abstract

Effective visualization of infectious disease risks is crucial for the development of efficient prevention and control strategies. However, the efficacy of mainstream models is hindered by a scarcity of reliable data in target areas, a situation that is particularly acute when dealing with emerging or re‐emerging infectious diseases. Additionally, these models typically fail to integrate local disease‐related risk factors in line with the ‘One Health’ concept, resulting in inaccurate predictions. Consequently, accurately assessing infectious disease risks without reliable data is challenging.

This study introduces SpatMCDA, an innovative R package designed to assess infectious disease risk areas through spatial multi‐criteria decision analysis (MCDA). SpatMCDA is structured around six core modelling steps: standardizing risk factors, determining factor weights, constructing risk maps, performing One‐at‐a‐Time sensitivity analysis, calculating the Mean of Absolute Change Rates and conducting an uncertainty analysis.

By examining the case of West Nile virus (WNV) in China, this study illustrates how SpatMCDA can be useful in identifying disease transmission risks in the absence of reliable outbreak data. The assessment identified areas at risk for WNV in northwestern, eastern and southern China.

By integrating spatial and epidemiological data, SpatMCDA enhances infectious diseases risk assessment in situations where data are limited. Its efficiency in using available data for accurate risk mapping and adaptability in weighting various risk factors enables tailored analyses. This tool enhances public health strategies, contributing to global health security.
Correlation of striatal dopamine D2/3 receptor availability with GABA level in the anterior cingulate cortex in healthy controls but not in alcohol‐dependent subjects and individuals at high risk: A multimodal magnetic resonance spectroscopy and positron emission tomography study
Authors: Spitta Gianna , Gleich Tobias , Rosenthal Annika , Schubert Florian , Aydin Semiha , Heinz Andreas , Buchert Ralph , Gallinat Jürgen 
Published: June 2024

AbstractBackgroundThe association of impaired dopaminergic neurotransmission with the development and maintenance of alcohol use disorder is well known. More specifically, reduced dopamine D2/3 receptors in the striatum of subjects with alcohol dependence (AD) compared to healthy controls have been found in previous studies. Furthermore, alterations of gamma‐aminobutyric acid (GABA) and glutamate (Glu) levels in the anterior cingulate cortex (ACC) of AD subjects have been documented in several studies. However, the interaction between cortical Glu levels and striatal dopamine D2/3 receptors has not been investigated in AD thus far.MethodsThis study investigated dopamine D2/3 receptor availability via 18F‐fallypride positron emission tomography (PET) and GABA as well as Glu levels via magnetic resonance spectroscopy (MRS) in 19 detoxified AD subjects, 18 healthy controls (low risk, LR) controls and 19 individuals at high risk (HR) for developing AD, carefully matched for sex, age and smoking status.ResultsWe found a significant negative correlation between GABA levels in the ACC and dopamine D2/3 receptor availability in the associative striatum of LR but not in AD or HR individuals. Contrary to our expectations, we did not observe a correlation between Glu concentrations in the ACC and striatal D2/3 receptor availability.ConclusionsThe results may reflect potential regulatory cortical mechanisms on mesolimbic dopamine receptors and their disruption in AD and individuals at high risk, mirroring complex neurotransmitter interactions associated with the pathogenesis of addiction. This is the first study combining 18F‐fallypride PET and MRS in AD subjects and individuals at high risk.
Responsibility to future generations: A strategy for combatting climate change across political divides
Authors: Syropoulos Stylianos , Law Kyle Fiore , Kraft‐Todd Gordon , Mah Andrea , Markowitz Ezra , Young Liane 
Published: June 2024

AbstractIndividuals and governments often fail to take action to address climate change owing largely to widespread politicization of the issue and related discourse. In response to recent appeals for non‐partisan approaches to pro‐environmentalism, we propose that highlighting one's responsibility to future generations (RFG) could offer promise across the political spectrum. We argue that RFG may be effective because it is widely endorsed, uncorrelated with demographic indicators and less tied to political ideology compared to other forms of responsibility, such as personal responsibility for climate change mitigation. Across six main and seven supplementary studies (N = 161,633), we provide evidence for these claims. RFG is not only widely endorsed across countries and demographic groups but it also significantly predicts various measures of pro‐environmental behaviour, both in correlational and pre‐registered experimental contexts. These findings confirm established effects, reconcile inconsistencies and suggest prioritizing intergenerational responsibility may effectively reshape climate change narratives for the most resistant parties.
Large language models reshaping molecular biology and drug development
Authors: Tripathi Satvik , Gabriel Kyla , Tripathi Pushpendra Kumar , Kim Edward 
Published: June 2024

AbstractThe utilization of large language models (LLMs) has become a significant advancement in the domains of medicine and clinical informatics, providing a revolutionary potential for scientific breakthroughs and customized therapies. LLM models are trained on large datasets and exhibit the capacity to comprehend and analyze intricate biological data, encompassing genomic sequences, protein structures, and clinical health records. With the utilization of their comprehension of the language of biology, they possess the ability to reveal concealed patterns and insights that may evade human researchers. LLMs have been shown to positively impact various aspects of molecular biology, including the following: genomic analysis, drug development, precision medicine, biomarker development, experimental design, collaborative research, and accessibility to specialized expertise. However, it is imperative to acknowledge and tackle the obstacles and ethical implications involved. The careful consideration of data bias and generalization, data privacy and security, explainability and interpretability, and ethical concerns around responsible application is vital. The successful resolution of these obstacles will enable us to fully utilize the capabilities of LLMs, leading to substantial progress in the fields of molecular biology and pharmaceutical research. This progression also has the ability to bolster influential impacts for both the individual and the broader community.
Denosumab, for osteoporosis, reduces the incidence of type 2 diabetes, risk of foot ulceration and all‐cause mortality in adults, compared with bisphosphonates: An analysis of real‐world, cohort data, with a systematic review and meta‐analysis
Authors: Henney Alex E. , Riley David R. , O'Connor Ben , Hydes Theresa J. , Anson Matthew , Zhao Sizheng Steven , Alam Uazman , Cuthbertson Daniel J. 
Published: June 2024

AbstractAimTo evaluate the impact of denosumab on (i) the incidence of type 2 diabetes (T2D), and (ii) long‐term health outcomes (microvascular [neuropathy, retinopathy, nephropathy] and macrovascular [cardiovascular disease, cerebrovascular accident] complications, and all‐cause mortality) in patients with T2D, before (iii) combining results with prior studies using meta‐analysis.MethodsA retrospective analysis of data in a large global federated database (TriNetX; Cambridge, MA) was conducted from 331 375 patients, without baseline T2D or cancer, prescribed either denosumab (treatment, n = 45 854) or bisphosphonates (control, n = 285 521), across 83 healthcare organizations. Propensity score matching (1:1) of confounders was undertaken that resulted in 45 851 in each cohort. Secondary analysis further evaluated the impact of denosumab on long‐term health outcomes in patients with T2D. Additionally, we systematically searched prior literature that assessed the association between denosumab and T2D. Estimates were pooled using random‐effects meta‐analysis. Risk of bias and evidence quality were assessed using Cochrane‐endorsed tools.ResultsDenosumab (vs. bisphosphonates) was associated with a lower risk of incident T2D over 5 years (hazard ratio 0.83 [95% confidence interval {CI} 0.78‐0.88]). Secondary analysis showed significant risk reduction in all‐cause mortality (0.79 [0.72‐0.87]) and foot ulceration (0.67 [0.53‐0.86]). Also, pooled results from four studies (three observational, one randomized controlled trial) following meta‐analysis showed a reduced relative risk (RR [95% CI]) for incident T2D in patients prescribed denosumab (0.83 [0.79‐0.87]) (I2 = 10.76%).ConclusionsThis is the largest cohort study to show that denosumab treatment is associated with a reduced RR of incident T2D, as well as an associated reduced RR of all‐cause mortality and microvascular complications, findings that may influence guideline development in the treatment of osteoporosis, particularly in patients who are at a high risk of T2D.
Navigating new norms: Essay and personal reflections on gender identity and affirming care
Authors: Meade Gavin 
Published: June 2024

AbstractGender‐affirming care saves lives. Research indicates that social interventions such as name/pronoun changes and medical interventions such as hormone therapy directly benefit youth and adolescents and can be a protective factor for the maladaptive effects of gender dysphoria and the all‐too‐common associated depression, anxiety, and suicidal ideation. This piece takes personal experiences supporting a sibling through their transition as well as the professional experiences garnered to comment on the impact of gender‐affirming care on a more personal level.
Relationship of microstructure on the mechanical and splitting fracture properties of a high carbon forging steel for connecting rod
Authors: Li Jin‐Cheng , Wang Xian‐Wen , Zhang Chao‐Lei , Liu Guanglei , Chen Lie 
Published: June 2024

AbstractThe influence of austenitizing temperature and isothermal transition temperature on the mechanical properties and splitting characteristics of C70S6 were investigated. The maximum ultimate tensile strength and yield strength were 1032 and 625 MPa, respectively, when the lamellar spacing of sorbite was 0.195 μm. The greatest elongation was 17% when the size of the pearlite colony was 13 μm, which suggested an approach for enhancing the properties of pearlite steel at a low cost. The splitting property performed excellent when the proeutectoid ferrite content is 0.3%, the prior austenite grain is 38.9 μm, and the yield ratio is 0.57 currently. The connection between the process performance and the microstructure parameters was established, allowing process improvement to be guided accurately.
The effects of mandala coloring on fatigue, psychological well‐being, and coping with stress in patients receiving hemodialysis treatment
Authors: Özer Zülfünaz , Bahçecioğlu Turan Gülcan , Uyman Mine , Mollaoğlu Mukadder 
Published: June 2024

AbstractBackgroundHemodialysis is an important health problem that negatively affects psychosocial status and support systems. Through practices such as mandala coloring, individuals transfer the unknowns they experience to the outside and make them visible. This study was conducted to examine the effects of mandala coloring on fatigue, psychological well‐being, and factors associate with coping with stress in patients receiving hemodialysis treatment.MethodsThe design was a prospective, parallel‐group controlled trial. The study was conducted in the dialysis unit of a university hospital in eastern Turkey between April 4 and October 31, 2022, with a total of 60 patients, 30 in the intervention group, and 30 in the control group. The patients in the intervention group colored mandala once a week for 2 h, for a total of 8 weeks. The data were collected face‐to‐face using a patient information form, a Fatigue Severity Scale, a Psychological Well‐Being Scale, and a Ways of Coping Questionnaire.ResultsThere were improvements in fatigue severity and psychological well‐being over the 8‐week study period in both the intervention and control groups. Scores were similar at baseline in the control and intervention groups, but better in the intervention groups compared to controls at 4 and 8 weeks for both metrics (p < 0001). Five factors from the Ways of Coping Questionnaire (self‐confident approach, optimistic approach, seeking social support, helpless approach, and submissive approach) each improved during the 8‐week period in the intervention group (p < 0.001). Three of these five factors improved in the control group as well. Scores for each of the five coping factors were better in the intervention group compared to controls at 4 and 8 weeks (p < 0.001).ConclusionMandala coloring improved fatigue and psychological well‐being and was associated with improved patient coping strategies.
A 3‐year follow‐up study of outcomes associated with patterns of traditional acute and preventive migraine treatment: An administrative claims‐based cohort study in the United States
Authors: Joshi Shivang , Spargo Andrew , Hoyt Margaret , Panni Tommaso , Viktrup Lars , Kim Gilwan , Hasan Anthony , Liu Yan Yun , Zakharyan Armen 
Published: June 2024

AbstractObjectiveTo describe treatment patterns and direct healthcare costs over 3 years following initiation of standard of care acute and preventive migraine medications in patients with migraine in the United States.BackgroundThere are limited data on long‐term (>1 year) migraine treatments patterns and associated outcomes.MethodsThis was a retrospective, observational cohort study using US claims data from the IBM® MarketScan® Research Database (January 2010–December 2017). Adults were included if they had a prescription claim for acute migraine treatments (AMT) or preventive migraine treatments (PMT) in the index period (January 2011–December 2014). The AMT cohort was categorized as persistent, cycled, or added‐on subgroups; the PMT cohort was categorized PMT‐persistent, switched without gaps, or cycled with gaps. Migraine‐specific annual direct costs (2017 US$) across AMT and PMT cohort subgroups were summarized at baseline through 3 years from index (follow‐up).ResultsDuring the index period, 20,778 and 42,259 patients initiated an AMT and a PMT, respectively. At the 3‐year follow‐up, migraine‐specific direct costs were lower in the persistent subgroup relative to the non‐persistent subgroups in both AMT (mean [SD]: $789 [$1741] vs. $2847 [$8149] in the added‐on subgroup and $862 [$5426] for the cycled subgroup) and PMT cohorts (mean [SD]: $1817 [$5892] in the persistent subgroup vs. $4257 [$11,392] in the switched without gaps subgroup and $3269 [$18,540] in the cycled with gaps subgroup). Acute medication overuse was lower in the persistent subgroup (1025/6504 [27.2%]) vs. non‐persistent subgroups (11,236/58,863 [32.2%] in cycled with gaps subgroup and 1431/6504 [39.4%] in the switched without gaps subgroup). Most patients used multiple acute (19,717/20,778 [94.9%]) or preventive (38,494/42,259 [91.1%]) pharmacological therapies over 3 years following treatment initiation. Gaps in preventive therapy were common; an average gap ranged from 85 to 211 days (~3–7 months).ConclusionMigraine‐specific annual healthcare costs and acute migraine medication overuse remained lowest among patients with persistent AMT and PMT versus non‐persistent treatment. Study findings are limited to the US population. Future studies should compare costs and associated outcomes between newer preventive migraine medications in patients with migraine.
Our Wished‐for Responses: Recommendations for Creating a Lived and Embodied Sense of Safety During Mental Health Crisis
Authors: Roennfeldt Helena , Hamilton Bridget Elizabeth , Hill Nicole , Castles Calista , Glover Helen , Byrne Louise , Roper Cath 
Published: June 2024

AbstractBackgroundMedical interventions have a place in crisis support; however, narrow biomedical and risk‐driven responses negatively impact people seeking crisis care. With increasing shifts towards involving people with lived experience (service users) in designing services, foregrounding people's desired responses is critical. Accordingly, the aim of the study was to explore the wished‐for crisis responses from the perspective of people who have experienced crisis and accessed crisis care.MethodUsing a hermeneutical phenomenological approach, in‐depth interviews were conducted to determine the desired crisis responses of 31 people who self‐reported experiencing mental health crises and accessed crisis services at ED, phone lines and/or crisis alternatives.ResultsThe findings identified wished‐for responses that gave a felt and embodied sense of their own safety influenced by a human‐to‐human response, emotional holding, a place of safety and choice within holistic care. For such responses to be possible, participants identified organising principles, including recognising crisis as meaningful and part of our shared human experience, understanding risk as fluid and a whole‐of‐community responsibility for responding to crises.ConclusionThis paper proposes how insights from people who have experienced crises can be translated into more beneficial crisis care.Patient or Consumer ContributionMost authors are in identified lived experience roles. The first author engaged with participants during the recruitment and interviews and was explicit regarding their lived experience. Service users were involved as advisors, providing input throughout the study.