bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mitomycin C in the treatment of early triple-negative locally advanced BRCA-associated breast cancer
Authors: Enaldieva D. A. , Krivorotko P. V. , Imyanitov E. N. , Donskih R. V. , Sokolenko A. P. , Azaova V. O. , Amirov N. N. , Bondarchuk Ya. Ig. , Levcheko V. E. , Ulrikh D. G. , Semiglazov V. F. 
Published: May 2024

Rationale. BRCA1 associated triple-negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer. At the same time, carcinomas that develop in carriers of BRCA1 mutations are characterized by extremely high sensitivity to DNA-damaging chemotherapy. Mitomycin C alone or in combination with platinum agents has already demonstrated promising results in the treatment of BRCA-associated ovarian cancer (OC) and metastatic breast cancer. In this article, we present the results of a retrospective study aimed at comparing standard neoadjuvant chemotherapy regimens (NACT) with mitomycin-based regimens for primary locally advanced BRCA1-associated TNBC.The aim of the study is to determine the effectiveness of the combination of mitomycin and platinum compounds during neoadjuvant therapy in patients with primary locally advanced BRCA1 – associated TNBC.Materials and methods. The study included 89 patients diagnosed with primary locally advanced BRCA1-associated TNBC. Patients were divided into three groups depending on the therapy: 1) 4 cycles of anthracycline and cyclophosphamide followed by 12 weekly injections of paclitaxel (n = 48) (AC + T), 2) 4 cycles of anthracycline and cyclophosphamide followed by 12 weekly injections of paclitaxel and carboplatin (n = 27) (AC + TCbP), 3) mitomycin C plus platinum followed by 12 weekly injections of paclitaxel (n = 14) (MR + T). Pathological complete response (pCR) rates were compared.Results. The pCR rate in the MP+T group was 10/14 (71%). In patients with BRCA1-associated breast cancer who received AC + T and AC + TCbP regimens as NACT, the pCR rate was 17/48 (35%) and 19/27 (70%), respectively. The difference in pCR rate between mitomycin-containing therapy and the standard AC + T regimen was statistically significant (p = 0.03); the frequency of regressions was comparable to the frequency in the AC + TCbP group. During the 20-month follow-up period, no relapses were observed in the MR + T group. Relapses were more frequent in the AC + T group compared with the AC + TCbP group (16/48 (33%) vs 1/27 (4%), p = 0.003, Fisher’s exact test). The toxicity profile of the mitomycin-containing regimen included hematologic adverse events, the most common of which were anemia and leukopenia. Compared to standard regimens, nausea was significantly less pronounced. No patients reported alopecia with this regimen.Conclusions. The addition of mitomycin C to neoadjuvant therapy for BRCA1-associated TNBC may be a promising treatment option for this category of patients and merits further study.
B vitamins and homocysteine in cancer patients with solid malignancies before chemotherapy administration
Authors: Tikhonova O. A. , Druzhinin D. S. , Litvinova L. S. , Doktorova S. A. , Todosenko N. M. , Gazatova N. D. , Bograya M. M. , Naumova E. L. , Dolgaleva M. I. 
Published: May 2024

Recently, the role of vitamin imbalance in carcinogenesis has been actively discussed. Studies aimed at assessing their role in the processes of cancer development are various, and the evaluation of the initial level of vitamins is relevant when planning antitumor therapy.Objective. To determine the state of the initial level of B vitamins and homocysteine before chemotherapy in patients of different oncologic profile.Material sand Methods. The level of vitamins B1, B6, B9, active form of B12* and homocysteine in fresh frozen plasma was determined by enzyme[1]linked immunosorbent assay (ELISA) using test systems in 66 patients with verified malignant neoplasms before chemotherapy. The study included 66 patients: women n=40 and men n=26, with cancer: gastric n=12, colorectal cancer n=21, cancer lung n=11, cancer pelvic organs n=22.Results. According to the results of the study the increase in the level of holotranscobalamin (Holo-TC) and decrease in homocysteine in comparison with reference values was observed in 100% of cases. Significant difference was found only for B1: reliable differences between patients with colorectal cancer and with pelvic cancer (in the latter the mean value of B1 levels was 2.4 times higher at p = 0.0425). According to the results of correlation analysis, a weak correlation between B12 and B9 was determined. When comparing the levels of vitamin B12 and homocysteine in patients after surgical treatment and without it, no significant differences were found.Conclusion. Increased Holo-TC levels and decreased homocysteine levels by ELISA are characteristic of all varieties of solid cancer, independent of sex, age, stage and previous surgical intervention. A relative decrease in vitamin B1 is characteristic of colorectal cancer
Association between the triglyceride glucose index and length of hospital stay in patients with heart failure and type 2 diabetes in the intensive care unit: a retrospective cohort study
Authors: Zhang Kai , Han Yu , Gao Yu Xuan , Gu Fang Ming , Cai Tianyi , Gu Zhao Xuan , Yu Zhao Jia , Min Gao , Gao Ya Fang , Hu Rui , Huang Mao Xun 
Published: May 2024

BackgroundThe coexistence of heart failure and diabetes is prevalent, particularly in Intensive Care Units (ICU). However, the relationship between the triglyceride-glucose (TyG) index, heart failure, diabetes, and the length of hospital stay (LHS) in patients with cerebrovascular disease in the ICU remains uncertain. This study aims to investigate the association between the TyG index and LHS in patients with heart failure and diabetes.MethodsThis retrospective study utilized the Medical Information Mart for Intensive Care (MIMIC)-IV database to analyze patients with diabetes and heart failure. Participants were categorized into quartiles based on the TyG index, and the primary outcome was LHS. The association between the TyG index at ICU admission and LHS was examined through multivariable logistic regression models, restricted cubic spline regression, and subgroup analysis.ResultsThe study included 635 patients with concurrent diabetes and heart failure. The fully adjusted model demonstrated a positive association between the TyG index and LHS. As a tertile variable (Q2 and Q3 vs Q1), the beta (β) values were 0.88 and 2.04, with a 95% confidence interval (95%CI) of -0.68 to 2.44 and 0.33 to 3.74, respectively. As a continuous variable, per 1 unit increment, the β (95% CI) was 1.13 (0.18 to 2.08). The TyG index’s relationship with LHS showed linearity (non-linear p = 0.751). Stratified analyses further confirmed the robustness of this correlation.ConclusionThe TyG index exhibited a linearly positive association with the LHS in patients with both heart failure and diabetes. Nevertheless, prospective, randomized, controlled studies are imperative to substantiate and validate the findings presented in this investigation.
Glocalization: an analysis into it’s conceptual and strategic underpinnings
Authors: Alamuri Suryanarayana , Aluvala Ravi 
Published: May 2024

Glocalization is a “simultaneity—the co-presence—of both universalizing and particularizing tendencies” emphasizing the need for tempering the effects of local conditions on global pressures. While the increasing presence of best-known fast food chain restaurants worldwide such as McDonald’s and KFC is a manifestation of globalization, the shrewd and strategic adaptations of their menu to satiate the local palates and tastes by these “Glocal Enterprises” is illustrative of glocalization. Conversely, the chief point of glocalization perspective is: “even the most local ways of carrying out business operations are more and more co-constituted by economic and social trends that are most global.” Language has a huge role to play in addressing the cultural and linguistic barriers and designing a successful global talent management and language learning solution that is complemented by local support. When used as an extension of the “Think Global, Act Local” grassroots movement, glocalization also refers to market advantage of local businesses versus global companies. In the face of globalization, both the little guys and would-be entrepreneurs can emerge triumphant by tapping into their hometown markets and then scaling up. However, it is imperative that MNCs restructure the national economies to become and remain more resilient, sustainable, and inclusive in their globalization to glocalization migration odyssey. An attempt would be made in this conceptual Paper to address this issue—a challenge and an opportunity—for the key players by enumerating the stories of successful transition into glocalization by several popular Multi National Corporations in the Indian context.
Currículo FIPAD-TCD: diretrizes iniciais para a reestruturação curricular da formação inicial de professores a distância com base na transversalidade das competências digitais
Authors: Silva Gleice Assunção da , Ramos Daniela Karine 
Published: May 2024

Este estudo aborda a formação inicial de professores em EAD, partindo da perspectiva de que o ambiente de formação pode proporcionar o desenvolvimento de competências digitais. O objetivo é sistematizar diretrizes iniciais do currículo de formação inicial de professores remotos com ênfase na transversalidade das competências digitais. Os resultados desta pesquisa apontam caminhos para a integração das competências digitais no currículo da formação inicial de professores a distância e na elaboração de vinte e cinco diretrizes para o desenho curricular das licenciaturas na modalidade a distância a partir da transversalidade das competências digitais.
Climate Change and Socio-Economic Impacts: Determinants of Vulnerability for Developing Countries
Authors: Dr. Afzaal Afzal  , Dr. Nazia Salah ud Din  , Dr. Sumera Tul Hasan  
Published: May 2024

Climate change is the connected system of solar cycle that creates fluctuations weather arrays across tropics to polls. Anticipated climate changes for the 21st century have been encountered complex challenges for humanity that significantly influence over diverse components such as environmental, ecological, socio-political and socio-economic systems among others. This study incorporates a desk literature review and at the first step researchers shortlisted the keywords regarding climate change, socioeconomic impacts and determinants of vulnerability. Mixed method approach applied for this desk review. Numerous online search engines such as Google, Google Scholar, Scopus, Web of Science and Springer were selected to review the published research studies. The collected data comprises on various forms such as book chapters, books, research articles, reports, working papers, organizational evaluation studies and conferences papers. After strict inclusion and exclusion criteria researchers gathered to 89 studies from 31 publications outlets, which were interrelated to different search engine and covering climate change impacts on developing countries. The findings endorsed the climate change socio-economic impacts are more sever particularly in developing countries of south Asia like Pakistan. The astonishing and spatial heterogeneities are the clear indications for comprehensive integrated interventions, policies and procedure to eliminate or reduce socio-economic climate change impacts of developing countries.
Keywords:	Climate change, Socio-economic impacts, Determinants of vulnerability,	Environmental degradation, climate change and developing countries
Following the 15th International Scientific and Practical Seminar of the Cycle “Dialogue of Civilizations and Intercultural Cooperation”
Authors: Горячев Ю.А. , Захаров В.Ф. , Кривенькая М.А. , Омельченко Е.А. , Власенко И.А. , Шевцова А.А. , Теплова Е.Ф. , Яшина О.Н. , Орлова А.Ю. , Хабенская Е.О. 
Published: May 2024

6–7 декабря 2023 года в Московском педагогическом государственном университете (Москва, РФ) состоялся XV международный научно-практический семинар из цикла «Диалог цивилизаций и межкультурное сотрудничество». Семинар проводился в рамках Года педагога и наставника в РФ и был приурочен к 70-летнему юбилею международного проекта «Ассоциированные школы ЮНЕСКО». Проблемное поле семинара включало следующие темы: потенциал научного знания и образования для мира и развития, право на образование для всех; роль учителя и просветителя в обществе, поддержка русского языка и образования на русском языке в мире, этнокультурное просвещение и межкультурная компетентность участников образовательного процесса, межэтнические и межконфессиональные отношения в образовании, адаптация и интеграция мигрантов средствами образования, гражданское образование и воспитание; цифровая среда и гуманизация образования.
On December 6-7, 2023, the 15th International Seminar of the cycle "Dialogue of Civilizations and Intercultural Cooperation" was held at the Moscow Pedagogical State University. Seminar was held in the Year of Teacher and Tutor in the Russian Federation and in the framework of the events dedicated to the 70th anniversary of the UNESCO Associated Schools Project. The subject matter of the seminar included: potential of scientific knowledge and education for peace and development; right to education for all; role of the teacher and educator in society; support of Russian language and education in Russian in the world; ethnocultural education and intercultural competence of educational process participants; interethnic and interreligious relations in education; adaptation and integration of migrants by means of education; civic education and awareness; digitalization and humanization of education.
Artist Alexander Yerashov about Suzdal anniversary, as well as creativity and heritage
Authors: Шевцова А.А. , Ерашов А.В. 
Published: May 2024

Вниманию читателей альманах «Этнодиалоги» предлагается интервью с современным российским и казахстанским художником-графиком и иллюстратором Александром Васильевичем Ерашовым, в котором особое внимание уделено серии графических листов «Летопись», в которой представлена тысячелетняя история Владимиро-Суздальской земли, включающая как известнейшие летописные исторические эпизоды, так и авторское прочтение героев, ситуаций, историко-культурного наследия. В серии уже более 70 листов, работа продолжается.
The readers of the almanac “Ethnodialogues” are invited to an interview with Alexander Yerashov, the contemporary Russian and Kazakh graphic artist and illustrator. Special attention is paid to his series of graphic sheets “Chronicle”, which presents a thousand-year history of the Vladimir-Suzdal land, including both the most famous chronicle historical episodes and the author's reading of heroes, situations, historical and cultural heritage. There are over 70 sheets in the series, the work continues.
Archaeological debut in the oldest city of Russia
Authors: Бурова А.А. 
Published: May 2024

В формате путевых заметок и дневниковых записей освещается первый опыт прохождения археологической практики студентами-первокурсниками направления «История и воспитательная работа» факультета регионоведения и этнокультурного образования Института социально-гуманитарного образования ФГБОУ ВО «Московский педагогический государственный университет».
The 1st year students of bachelor degree program «History and educational work» at the Faculty of Regional Studies and Ethno-Cultural Education, Institute of Social and Humanitarian Education, Moscow Pedagogical State University. This article represents the first experience of archaeological work in the form of travel notes and diaries written by the 1st year students of Moscow Pedagogical State University (MPGU) who choose History and educational work as their first qualification.
Multicultural educational environment as a condition for the formation of socially significant qualities of students
Authors: Осипова М.В. 
Published: May 2024

Автор рассматривает проблему формирования социально значимых качеств обучающихся в поликультурной образовательной среде. Задачами современной школы являются максимальное раскрытие индивидуальных способностей каждого обучающегося, воспитание цельной личности, готовой к адаптации в быстро меняющемся мире. Современному обществу, как и современному образованию, необходима свободная, творчески развитая личность, наделенная определенными социально значимыми качествами. Раскрыты теоретические понятия социально значимых качеств личности в работах отечественных педагогов. Автор характеризует важность формирования данных качеств среди подрастающего поколения. Необходимые умения и навыки межкультурного и межличностного взаимодействия в обществе и достижение уровня поликультурной образованности является одним из важных критериев качества современной системы образования. Также автор выделила организацию проектной деятельности в условиях поликультурной образовательной среды как составляющую часть учебно-воспитательной работы, которая будет способствовать формированию социально значимых качеств у обучающихся.
The author examines the problem of developing socially significant qualities of learners in a multicultural educational environment. The objectives of a modern school are to maximize the individual abilities of each learner and to develop an integral personality ready to adapt to a rapidly changing world. Modern society, like modern education, requires a free, creatively developed personality, endowed with certain socially significant qualities. The article reveals the theoretical concepts of socially significant personality traits in the works of domestic teachers. The author characterizes the importance of developing these qualities among the younger generation, for whom the necessary skills and abilities of intercultural and interpersonal interaction in society and achieving a level of multicultural education is one of the important criteria for the quality of the modern education system. The author also highlights the organization of project activities in a multicultural educational environment as an integral part of educational work that will contribute to the formation of socially significant qualities in learners.
Análisis de las Estrategias Implementadas Hacia el Mejoramiento del Ahorro, la Fidelización y la Cobertura en los Vinculados al Programa BEPS en el Departamento de Santander
Authors: Velasquez Villar Maria Consuelo , Castillo Tavera Fernando 
Published: May 2024

El programa Beneficios Económicos Periódicos, Beps, de Colpensiones, cumple siete años de operación en el país, logrando en este tiempo más de 1,7 millones de colombianos vinculados. Asimismo, ha beneficiado a 40.599 personas mayores a través de las Anualidades Vitalicias. (La República, 2022). A través de esta investigación se realizó un análisis de las estrategias implementadas hacia el mejoramiento del ahorro, la fidelización y la cobertura en los vinculados al programa BEPS en el departamento de Santander con el fin proponer un plan de acción dirigido hacia el mejoramiento del ahorro, la fidelización y la cobertura en los vinculados al programa BEPS. Para lograr lo anterior se realizó una investigación de tipo analítico-descriptivo, con un enfoque cualitativo; mediante técnicas de recolección de información como la encuesta y la publicación de informes consolidados por parte de Colpensiones para determinar el cumplimiento de las metas establecidas.
Conception des enseignants universitaires marocains à propos de l’enseignement efficace
Authors: Mkhdramine Said , Essafi Khadija 
Published: May 2024

Cette étude a deux objectifs : (1) déterminer les caractéristiques de l’enseignement efficace de point de vue des enseignants du supérieur ; et (2) identifier leur conception quant à ce concept. Les auteurs ont tenté d'atteindre ces objectifs par le biais d’une enquête. Douze enseignants universitaires, du département des sciences de la vie de la faculté des sciences, ont été sollicités répondre à un questionnaire qualitatif. Les résultats nous ont permis d’énumérer 23 caractéristiques de l’enseignement efficace. Leur répartition en catégories, nous a permis de conclure que les enseignants constituant notre échantillon adoptent une conception d’enseignement efficace axée sur l’étudiant.
Dynamical Modeling and Dynamic Characteristics Analysis of a Coaxial Dual-Rotor System
Authors: Yue Yubin , Wang Hongjun , Zhang Shenglun 
Published: May 2024

The dual-rotor structure is the primary excitation source of aero-engine vibration. It is essential to study the dynamical model and analyse the dynamic characteristics such as critical speed and the unbalanced response for rotor system dynamics. The coaxial dual-rotor support scheme of an aero-engine was introduced in the previous work, and the physical model with a high-speed flexible inner rotor of a sizeable length-diameter ratio has been designed. Then a finite element dynamic model based on the Timoshenko beam elements and rigid body kinematics of the dual-rotor system is modelled, with the Newmark-β method and Newton-Raphson method used for the numerical calculation to study the dynamic characteristics of the system. Three different simulation models, including beam-based FE (1D finite element) model, solid-based FE (3D finite element) model, and TM (transfer matrix) model, were designed to study the characteristics of mode and the critical speed characteristic of the dual-rotor system. The unbalanced response of the dual-rotor system was analysed to study the influence of mass unbalance on the rotor system. The effect of different disc unbalance phases and different speed ratios on the dynamic characteristics of the dual-rotor system were investigated in detail. The experimental result shows that the beam-based FE model is effective and suitable for studying the dual-rotor system.

Conflict of Interest Statement
The authors declare no conflicts of interest.
PHUBBING DALAM PERSPEKTIF ETIS TOLOGIS: KAJIAN MEREDUKSI ANTI SOSIAL DALAM MASYARAKAT
Authors: Budiyana Hardi , Arifianto Yonatan Alex , Purdaryanto Samuel 
Published: May 2024

Kecanggihan teknologi dan informasi yang kian masif hadir untuk memanjakan dan membantu manusia melakukan tugasnya dengan mudah, namun ketergantungan atau kecanduan akan gadget memicu timbulnya karakter baru dalam masyarakat. Salah satu karakter baru yang muncul di era teknologi ini yaitu phubbing. Tujuan penulisan Artikel ini, agar umat Tuhan dapat memahami pentingnya sikap menghargai dalam komunikasi. Dan prilaku tersebut dapat merusak hubungan. Menggunakan metode kualitatif dengan pendekatan studi literatur dan wawancara maka dapat disimpulkan bahwa kekristenan harus mengetahui hakikat dan definisi phubbing dan dampaknya, dimana Phubbing merupakan perilaku kurang peduli dianggap sebagai perilaku anti-sosial yang dapat merusak hubungan sosial dan kesehatan mental. Maka orang Kristen dapat menggunakan prinsip-prinsip Alkitab untuk membimbing perilaku dan interaksi dengan orang lain, termasuk penggunaan teknologi dan memberikan pengajaran pendidikan Kristen terkait menghormati dan menempatkan skala prioritas dalam peribadatan. Phubbing dan anti sosial dalam perspektif etis teologis dapat dianggap sebagai perilaku yang mereduksi anti-sosial dalam masyarakat. Oleh karena itu, menghindari phubbing dapat membantu meningkatkan kualitas hubungan sosial dan mengurangi dampak negatif dari kebiasaan ini pada kesehatan mental. Maka aktualisasi dari peran gereja dalam mereduksi anti sosial dapat dilakukan dengan berbagai cara untuk menghindari sikap dan prilaku phubbing.