bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interleukin-30: A novel antiinflammatory cytokine candidate for prevention and treatment of inflammatory cytokine-induced liver injury
Authors: Dibra Denada , Cutrera Jeffry , Xia Xueqing , Kallakury Bhaskar , Mishra Lopa , Li Shulin 
Published: November 2011

Abstract

The liver is the major metabolic organ and is subjected to constant attacks from chronic viral infection, uptake of therapeutic drugs, life behavior (alcoholic), and environmental contaminants, all of which result in chronic inflammation, fibrosis, and, ultimately, cancer. Therefore, there is an urgent need to discover effective therapeutic agents for the prevention and treatment of liver injury, the ideal drug being a naturally occurring biological inhibitor. Here we establish the role of IL30 as a potent antiinflammatory cytokine that can inhibit inflammation-induced liver injury. In contrast, interleukin (IL)27, which contains IL30 as a subunit, is not hepatoprotective. Interestingly, IL30 is induced by the proinflammatory signal such as IL12 through interferon-gamma (IFN-γ) / signal transducer and activator of transcription 1 signaling. In animal models, administration of IL30 by way of a gene therapy approach prevents and treats both IL12-, IFN-γ-, and concanavalin A-induced liver toxicity. Likewise, immunohistochemistry analysis of human tissue samples revealed that IL30 is highly expressed in hepatocytes, yet barely expressed in inflammation-induced tissue such as fibrous/connective tissue. Conclusion: These novel observations reveal a novel role of IL30 as a therapeutic cytokine that suppresses proinflammatory cytokine-associated liver toxicity. (Hepatology 2012)
Brief review on physiological and biochemical evaluations of human mental workload
Authors: Lean Ying , Shan Fu 
Published: November 2011

AbstractThis paper gives a brief review and short summary on physiological and biochemical evaluations of human mental workloads. Physiological evaluations consist of peripheral physiological evaluations and central physiological evaluations. Peripheral physiological evaluations mainly include heart rate and heart rate variability (HRV) recorded from electrocardiograms (ECGs), blood pressure, respiration, eye blinks, skin potential, and hemodynamic indices. Central physiological evaluations mainly refer to the cerebral cortex, including electroencephalograms (EEGs) and event‐related potentials (ERPs). Biochemical evaluations mainly include catecholamines, cortisol, and immunoglobulin A (IgA) collected from blood, salivary, or urinary samples. They are all objective measurements to evaluate mental workloads when particular mental tasks are performed. © 2011 Wiley Periodicals, Inc.
Modelling in‐pool temperature variability in a beaded arctic stream
Authors: Merck M. F. , Neilson B. T. 
Published: November 2011

AbstractThis study examines the variability of in‐pool temperatures in Imnavait Creek, a beaded arctic stream consisting of small pools connected by shallow chutes, for the purpose of predicting potential impacts of climate variations on the system. To better understand heat fate and transport through this system, the dominant heat sources and sinks creating and influencing thermal stratification within even the smallest and shallowest pools must be quantified. To do this, temperature data were collected vertically within the pool water column and surrounding bed sediments during stratified conditions. These temperature and other supporting data (e.g. instream flow, weather data, and bathymetry) were used to formulate and develop an instream temperature model that captures the site‐specific processes occurring within the pools during summer low flow conditions. The model includes advective, air–water interface, and bed conduction fluxes, simplified vertical exchange between stratified pool layers, and attenuation of shortwave radiation within the water column. We present the model formulation, data collection methods used in support of model development and population, and the resulting model calibration and validation for one of the study pools. We also provide information regarding dominant heat sources and sinks and residence times of different layers within the stratified pool. We found that the dominant heat sources vary between stratified layers and that increases in thaw depths surrounding these pools due to possible climate changes can shift stratification, mixing, and instream storage dynamics, thereby influencing the fate and transport of heat and other constituents of interest (e.g. nutrients). Copyright © 2011 John Wiley & Sons, Ltd.
Spontaneous antibody, and CD4 and CD8 T‐cell responses against XAGE‐1b (GAGED2a) in non‐small cell lung cancer patients
Authors: Ohue Yoshihiro , Eikawa Shingo , Okazaki Nami , Mizote Yu , Isobe Midori , Uenaka Akiko , Fukuda Minoru , Old Lloyd J. , Oka Mikio , Nakayama Eiichi 
Published: November 2011

AbstractThe spontaneous immune responses against XAGE‐1b (GAGED2a) were analyzed in non‐small cell lung cancer (NSCLC) patients. An antibody response against XAGE‐1b (GAGED2a) was observed in 10% (20/200) of NSCLC patients and in 19% (13/69) of stage IIIB/IV lung adenocarcinoma patients. A CD4 T‐cell response was detected in 88% (14/16) and a CD8 T‐cell response in 67% (6/9) in the XAGE‐1b (GAGED2a) antibody‐positive patients examined. Frequent antibody responses and CD4 and CD8 T‐cell responses in XAGE‐1b (GAGED2a) antibody‐positive patients indicate the strong immunogenicity of the XAGE‐1b (GAGED2a) antigen in NSCLC patients. We established T‐cell clones from PBMCs of antibody‐positive patients and determined the DRB1*04:05‐restricted XAGE‐1b (GAGED2a) 18–31 peptide (14‐mer) as a CD4 T cell epitope and the A*02:06‐restricted XAGE‐1b (GAGED2a) 21‐29 peptide (9‐mer) as a CD8 T cell epitope. As for peptide recognition, CD4 and CD8 T‐cell clones responded to naturally processed antigen. The CD4 T‐cell clone recognized DCs pulsed with the synthetic protein or a lysate from XAGE‐1b‐transfected 293T cells. The CD8 T‐cell clone showed cytotoxicity against a tumor expressing XAGE‐1b (GAGED2a) and the appropriate HLA class I allele. These findings establish XAGE‐1b (GAGED2a) as a promising target for a lung cancer vaccine.
Targeting Radioresistant Osteosarcoma Cells With Parthenolide
Authors: Zuch Daniel , Giang An‐Hoa , Shapovalov Yuriy , Schwarz Edward , Rosier Randy , O'Keefe Regis , Eliseev Roman A. 
Published: November 2011

AbstractOsteosarcoma is a devastating tumor of bone, primarily affecting adolescents. Osteosarcoma tumors are notoriously radioresistant. Radioresistant cancers, including osteosarcoma, typically exhibit a considerable potential for relapse and development of metastases following treatment. Relapse and metastatic potential can, in part, be due to a specific radioresistant subpopulation of cells with stem‐like characteristics, cancer stem cells, which maintain the capacity to regenerate entire tumors. In the current study, we have investigated whether in vitro treatments with parthenolide, a naturally occurring small molecule that interferes with NF‐κB signaling and has various other effects, will re‐sensitize cancer stem cells and the entire cell population to radiotherapy in osteosarcoma. Our results indicate that parthenolide and ionizing radiation synergistically induce cell death in LM7 osteosarcoma cells. Importantly, the combination treatment results in a significant reduction in the viability of both the overall population of osteosarcoma cells and the cancer stem cell subpopulation. This effect is dependent on the ability of parthenolide to induce oxidative stress. Therefore, as a supplement to current multimodal therapy, parthenolide may sensitize osteosarcoma tumors to radiation and greatly reduce the prevalence of relapse and metastatic progression. J. Cell. Biochem. 113: 1282–1291, 2012. © 2011 Wiley Periodicals, Inc.
On Meyniel's conjecture of the cop number
Authors: Lu Linyuan , Peng Xing 
Published: November 2011

AbstractMeyniel conjectured that the cop number c(G) of any connected graph G on n vertices is at most for some constant C. In this article, we prove Meyniel's conjecture in special cases that G has diameter 2 or G is a bipartite graph of diameter 3. For general connected graphs, we prove , improving the best previously known upper‐bound O(n/ lnn) due to Chiniforooshan.
Responses of cucumber grown in recirculating nutrient solution to gradual Mn and Zn accumulation in the root zone owing to excessive supply via the irrigation water
Authors: Tzerakis Constantinos , Savvas Dimitrios , Sigrimis Nick 
Published: November 2011

AbstractA standard and a high manganese (Mn) level (10 and 160 μM) were combined with a standard and a high zinc (Zn) level (4 and 64 μM) in the nutrient solution supplied to cucumber in closed‐cycle hydroponic units to compensate for nutrient uptake. The concentrations of all nutrients except Mn and Zn were identical in all treatments. The objectives of the experiment were to establish critical Zn and Mn levels in both nutrient solutions and leaves of cucumber grown hydroponically, to assess the impact of gradual Zn and/or Mn accumulation in the external solution on nutrient uptake and gas exchange, and to find whether Mn and Zn have additive effects when the levels of both ions are excessively high in the root zone. The first symptoms of Mn and Zn toxicity appeared when the concentrations of Mn and Zn in the leaves of cucumber reached 900 and 450 mg kg–1 in the dry weight, respectively. Excessively high Mn or/and Zn concentrations in the leaves reduced the fruit biomass production due to decreases in the number of fruits per plant, as well as the net assimilation rate, stomatal conductance, and transpiration rate, but increased the intercellular CO2 levels. Initially, the Mn or Zn concentrations in the recirculating nutrient solution increased rapidly but gradually stabilized to maximal levels, while the corresponding concentrations in the leaves constantly increased until the end of the experiment. The uptake of Mg, Ca, Fe, and Cu was negatively affected, while that of K and P remained unaffected by the external Mn and Zn levels. The combination of high Mn and Zn seems to have no additive effects on the parameters investigated.
Nanoshell assisted laser soldering of vascular tissue
Authors: Schöni Daniel S. , Bogni Serge , Bregy Amadé , Wirth Amina , Raabe Andreas , Vajtai Istvan , Pieles Uwe , Reinert Michael , Frenz Martin 
Published: November 2011

AbstractBackground and ObjectivesLaser tissue soldering (LTS) is a promising technique for tissue fusion but is limited by the lack of reproducibility particularly when the amount of indocyanine green (ICG) applied as energy absorber cannot be controlled during the soldering procedure. Nanotechnology enables the control over the quantitative binding of the ICG. The aim of this study was to establish a highly reproducible and strong tissue fusion using ICG packed nanoshells. By including the chromophore in the soldering scaffold, dilution of the energy absorber during the soldering procedure is prevented. The feasibility of this novel nanoshell soldering technique was studied by assessing the local heating of the area and tensile strength of the resulting fused tissue.Study Design/Materials and MethodsNanoshells with a diameter of 250–270 nm were loaded with ICG and included in a porous polycaprolactone (PCL) scaffold doped with albumin solder. The nanoshell scaffold was used in a flexible, semi‐dry formulation suitable for surgical use. Heat development, tensile strength as well as tissue damage were assessed.ResultsRabbit aortic arteries were successfully soldered using an ICG packed nanoshell scaffold. Tensile strengths of these nanoshell soldered anastomoses were found to be 734 ± 327 mN (median = 640 mN). Thermal damage was restricted to the adventitia at the irradiated area. In addition, absorber dilution was prevented during the soldering procedure resulting in significantly lower variance in maximum temperature (P = 0.03) compared to the classical liquid ICG soldering technique.ConclusionUsing nanoshells, controlled amounts of chromophore could successfully be bound into the polymer scaffold. Diode laser soldering of vascular tissue using ICG‐nanoshell scaffolds leads to strong and reproducible tissue fusion. With optimally chosen settings of irradiation time, nanoshells coating and scaffold properties, our improved LTS procedure demonstrates the potential for a clinically applicable anastomosis technique. Lasers Surg. Med. 43:975–983, 2011. © 2011 Wiley Periodicals, Inc.
Formation of Structured Polygonal Nanoparticles by Phase‐Separated Comb‐Like Polymers
Authors: Weiss Verena M. , Naolou Toufik , Amado Elkin , Busse Karsten , Mäder Karsten , Kressler Jörg 
Published: November 2011

AbstractA simple approach using comb‐like polymers that undergo nanophase separation between the polyester backbone and the stearoyl side chains is proposed for the preparation of structured non‐spherical nanoparticles from a nanoemulsion. Depending on the degree of esterification of the OH groups of poly(glycerol adipate) differently ordered nanostructures is obtained. A perfect lamellar arrangement is obtained for polymers with a high degree of esterification and leads to spherical nanoparticles with an internal onion‐like structure. However, when the degree of esterification is only 20 mol%, polygonal nanoparticles with an internal pseudo‐hexagonal structure are obtained. The differences in the nanoparticle shapes are related to the volume fraction of the paraffinic pool.
Propagation and excitation of the higher‐order E mode in an insulated image guide
Authors: Dolatsha Nemat , Hesselbarth Jan 
Published: November 2011

AbstractThe use of E mode in an insulated image guide is proposed. This mode has much lower conductor loss than the fundamental, E mode. The electric field of the mode is primarily parallel to the metal ground‐plane; therefore, the mode can be efficiently excited with a compact dipole structure oriented parallel to the ground‐plane. When the insulating layer is of low permittivity and relatively thick, the E mode exhibits the highest effective permittivity (largest propagation constant) of all modes. This reduces unwanted mode coupling at discontinuities. Two example structures, a straight line and a double‐bended line are measured at frequencies around 8 GHz. The excitation of the waveguide causes insertion loss of less than 0.4 dB, and the radiation loss of the bends and the waveguide itself appears to be negligible. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:179–181, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26450
Switchable loop‐loaded printed dipole antenna with a balun/feed structure
Authors: Sondas Adnan , Ucar Mustafa H. B. , Erdemli Yunus E. 
Published: November 2011

AbstractA switchable loop‐loaded printed dipole antenna is introduced for a frequency‐tuning operation. Two loop elements with extensions are placed asymmetrically at each side of a twisted dipole excited by a balun/feed vertically placed underneath the dipole. PIN diodes are used between each loop element and its extension to achieve switchable antenna operation for 3 and 5.5 GHz bands. Simulated and measurement results are presented to demonstrate the proposed tuning performance. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:76–79, 2012, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26453
Fabrication and sensing characteristics of the chemical composition grating sensor at high temperatures
Authors: Li Guoyu , Liu Mingsheng , Li Yan , Guan Bai‐ou 
Published: November 2011

AbstractThe fabrication of the chemical composition gratings at high temperatures has been described.In the process of chemical composition, gratings formation, annealing, and development are necessary steps. Furthermore, the sensing characteristics of chemical composition grating sensor have been studied. Experimental results show that the temperature response is nonlinear over a temperature range from room temperature to 900°C, strain response of chemical composition grating sensor is linear at each temperature, and the strain sensitivity of the chemical composition grating sensor is about 1.10 pm με−1 over a temperature range from room temperature to 900°C. So, the chemical composition grating sensors will be an attractive solution for sensing application at high‐temperature environments. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26454
RF B1 field localization through convex optimization
Authors: Olson Chris , Yoo Hyoungsuk , Delabarre Lance , Vaughan J.Thomas , Gopinath Anand 
Published: November 2011

AbstractA 9‐cm wavelength in the human brain at the 400‐MHz Larmor frequency for 9.4‐T leads to pronounced B1 field contours and consequential image inhomogeneity. The objective of this study was to develop a new technique to control this nonuniformity by designing the phase and magnitude of radiofrequency (RF) power emanating from RF coil antenna elements in a multichannel transceiver array. Nonuniformity was used to steer a constructively interfering B1 field node to spatially correlate with an anatomic region of interest. This work outlines a convex (quadratically constrained quadratic problem) formulation of the B1 localization problem and the benefits of such a formulation. This convex formulation was used to design antenna excitation magnitude and phase. Localization is demonstrated in simulated finite difference time domain (FDTD) B1 field human head distributions and human head phantom measurement. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:31–37, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26456
Low‐cost, compact printed circular monopole UWB antenna with 3.5/5.5‐GHz dual band‐notched characteristics
Authors: Mishra Sanjeev K. , Gupta Rajiv K. , Vaidya Avinash , Mukherjee Jayanta 
Published: November 2011

AbstractIn this article, a low‐cost, compact printed microstrip‐fed circular monopole ultra‐wideband antenna with dual band‐notched function is proposed.By embedding a C‐shaped slot on the circular radiating patch and a pair of L‐shaped slots on the rectangular ground patch, dual band notched characteristics around 3.5 GHz for WiMAX and 5.5 GHz for wireless local‐area network (WLAN) can be obtained. The proposed antenna is designed, fabricated, and tested. The measured results show UWB impedance bandwidth with dual notch, stable radiation patterns, and constant gain. The proposed antenna, with a compact dimension of 24 × 36 mm2, operates over the frequency band from 2.5 to 10.6 GHz with S11 ≤ −10 dB, except the over the dual notch bands of 3.3–4.2 and 5.1–5.9 GHz. Group delay and transfer function indicate that the antenna has good transient response. In addition, the radiation patterns are nearly omnidirectional in H‐plane and typical monopole‐like in E‐plane. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:242–246, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26457
A circularly polarized microstrip antenna with an arrow‐shaped slotted ground
Authors: Pyo Seongmin , Sung Youngje 
Published: November 2011

AbstractA new microstrip antenna employing an arrow‐shaped slotted ground has been developed to enable circularly polarized radiation with a super‐compact size. By embedding the axis‐symmetrical arrow‐shaped slot on the ground plane, the resonant frequency is substantially lowered and orthogonally polarized modes are achieved without any degradation in the radiation performance. Simulated and measured results show that the proposed antenna has about a 62% reduction in size and a remarkable circular polarization performance at the resonant frequency. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:271–273, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26466
Novel CPW‐FED printed monopole antenna with an n‐shaped slot for dual‐band operations
Authors: Fan S. T. , Yin Y. Z. , Hu W. , Song K. , Li B. 
Published: November 2011

AbstractA novel coplanar waveguide (CPW)‐fed printed monopole antenna with an n‐shaped slot for dual‐band operations is proposed. By etching an n‐shaped slot on the radiating element, two tunable operating bands can be obtained. The measured results indicate that the impedance bandwidths of the proposed antenna, defined by 10‐dB return loss, are 13.6% (1.85–2.12 GHz) and 5.7% (2.39–2.53 GHz), covering the required bandwidths for PCS (1850.5–1989.5 MHz), CDMA2000 (1850–1990 MHz), TD‐SCDMA (1880–2025 MHz), and 2.4 GHz WLAN (2400–2484 MHz). In addition, good omnidirectional radiation characteristics have been obtained over the entire frequency range of interest. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:240–242, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26475
Branch line coupler using hybrid T‐model structure
Authors: Ali Mohamad , Rahim S.K. A. , Nor M. Z. M. , Jamlos M. F. 
Published: November 2011

AbstractA reduced size branch line coupler (BLC), which does not use bonding wires, lumped elements, or via holes, is reported in this article. The technique presented uses T‐model approach, which is a combination of low‐impedance and high‐impedance quarter wave transmission lines for realizing the proposed structure. The coupler's operating frequency bandwidth is between 2.1 and 2.67 GHz, and its size has been reduced by almost 75.31% compared with the conventional BLC. The S‐parameters and the phase difference between the output ports are simulated using CST microwave studio, and the simulation results have been compared with the measurements. The BLC has been designed to operate at 2.5 GHz and fabricated on flame resistance board (FR4 Board). The study shows that there is good agreement between the simulated and measured results. The proposed coupler has promising potentials for beam‐forming network applications such as butler matrix due to its smaller size. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:237–240, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26476
Investigation of optical clock division and demultiplexing based on a commercial lithium niobate‐intensity modulator
Authors: Yu Wenke , Lu Dan , Huo Li , Lou Caiyun , Zhao Xiaofan 
Published: November 2011

AbstractWe demonstrate and investigate a simple technique to realize multichannel optical clock division by using a commercial lithium niobate‐intensity modulator (LN‐IM). Optical clock division is achieved by controlling the driving and dc bias voltage of the LN‐IM. 20‐ to 10‐GHz optical clock division experiments of both single and double channel are implemented to verify the performance of the proposed optical clock divider. The phase noise of the extracted 10‐GHz optical clock is less than 95 dBc/Hz. The other function of this technique, demultiplexing of optical time division multiplexing (OTDM) signal is also demonstrated experimentally. The 20‐Gb/s PRBS OTDM signal is successfully demultiplexed to two 10 Gb/s with high quality. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:94–99, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26477