bluuebunny/crossref_metadata_2025_split huggingface dataset:
Excimer laser coronary angioplasty combined with drug‐coated balloon in the treatment of in‐stent restenosis
Authors: He Pan , Chen Haiwei , Yang Junjie , Gao Lei , Guo Jun , Chen Yundai , Wang Qi 
Published: May 2024

AbstractObjectivesThe aim of this study is to investigate the safety and efficacy of excimer laser coronary angioplasty (ELCA) combined with drug‐coated balloons (DCBs) in the treatment of in‐stent restenosis (ISR), and to explore whether the contrast injection technique would improve the neointimal tissue ablation of ELCA.MethodsWe studied patients diagnosed with ISR between January 2019 and October 2022 at two medical centers. These patients underwent DCB angioplasty guided by optical coherence tomography (OCT). Based on whether ELCA was performed before DCB treatment, patients were categorized into two groups: the ELCA + DCB group and the DCB group. All patients underwent clinical follow‐up 1 year after the procedure. The primary endpoint was the 1‐year rate of target lesion revascularization (TLR), which was defined as any repeat percutaneous intervention or bypass surgery on the target vessel conducted to address restenosis or other complications related to the target lesion. The secondary endpoints including immediate luminal gain (ΔMLA, defined as the difference in minimum lumen area before and after the intervention).ResultsA total of 85 lesions in 75 patients were included. The mean age of the study population was 64.2 ± 12.0 years, with 81.3% male. Baseline clinical characteristics were well‐balanced, and procedural success was 100% in both groups. The ELCA + DCB group (n = 24) exhibited a greater ΔMLA compared to the DCB group (n = 61) (3.57 ± 0.79 mm² vs. 2.50 ± 1.06 mm², [95% confidence interval, CI: 0.57–1.69],p < 0.001), The reduction in 1‐year TLR was more frequently observed in patients from the ELCA + DCB group compared to the DCB group (hazard ratio 0.33 [95% CI: 0.11–0.99]; log‐rankp = 0.048). The exploratory analysis showed that ELCA with contrast infusion is associated with greater acute lumen gain compared to ELCA with saline infusion (p < 0.001).ConclusionsThe combination of ELCA and DCB is a safe and effective treatment strategy for in‐stent stenosis. Additionally, compared with saline injection, ELCA with contrast injection is associated with greater acute lumen gain. However, the optimal contrast agent concentration and long‐term outcome of the contrast injection technique need confirmation through larger sample sizes and prospective studies.
Current progress in chimeric antigen receptor T‐cell therapy for malignant tumors
Authors: Zheng Yashang , Huang Jiaqian , Xu Yuhong , Luo Hui‐Yan 
Published: May 2024

AbstractIn the realm of malignant tumor treatment, particularly regarding hematologic malignancies, chimeric antigen receptor T‐cell (CAR‐T) immunotherapy has witnessed remarkable advancements in recent years. This approach involves genetically modifying and engineering a patient's T‐cells ex vivo to express a specific CAR, known as CAR‐T cells. When these modified cells are reintroduced into the patient, they can specifically recognize target antigens and exhibit highly efficient cytotoxicity against cells expressing these antigens, making them suitable for the treatment of malignant tumors. CD19, which is expressed on the surface of B lymphocytes at different stages of differentiation, has been identified as a suitable target for the treatment of most B‐cell lymphomas. CAR‐T cells targeting CD19 have demonstrated excellent specificity, cytotoxicity, and persistence in both in vitro and clinical trials, showing tremendous potential for application. However, identifying appropriate targets for CAR‐T therapy in solid tumors remains a challenge, leading to limited advancements in this area. This review discusses the mechanisms, applications, limitations, and prospects of CAR‐T therapy in hematologic malignancies and solid tumors, aiming to provide directions for future research in this field.
Fusarium mycotoxins: The major food contaminants
Authors: Qu Zheng , Ren Xianfeng , Du Zhaolin , Hou Jie , Li Ye , Yao Yanpo , An Yi 
Published: May 2024

AbstractMycotoxins, which are secondary metabolites produced by toxicogenic fungi, are natural food toxins that cause acute and chronic adverse reactions in humans and animals. The genus Fusarium is one of three major genera of mycotoxin‐producing fungi. Trichothecenes, fumonisins, and zearalenone are the major Fusarium mycotoxins that occur worldwide. Fusarium mycotoxins have the potential to infiltrate the human food chain via contamination during crop production and food processing, eventually threatening human health. The occurrence and development of Fusarium mycotoxin contamination will change with climate change, especially with variations in temperature, precipitation, and carbon dioxide concentration. To address these challenges, researchers have built a series of effective models to forecast the occurrence of Fusarium mycotoxins and provide guidance for crop production. Fusarium mycotoxins frequently exist in food products at extremely low levels, thus necessitating the development of highly sensitive and reliable detection techniques. Numerous successful detection methods have been developed to meet the requirements of various situations, and an increasing number of methods are moving toward high‐throughput features. Although Fusarium mycotoxins cannot be completely eliminated, numerous agronomic, chemical, physical, and biological methods can lower Fusarium mycotoxin contamination to safe levels during the preharvest and postharvest stages. These theoretical innovations and technological advances have the potential to facilitate the development of comprehensive strategies for effectively managing Fusarium mycotoxin contamination in the future.
Pathogenic mechanisms and etiologic aspects of Mycobacterium avium subspecies paratuberculosis as an infectious cause of cutaneous melanoma
Authors: Pierce Ellen S. , Jindal Charulata , Choi Yuk Ming , Cassidy Kaitlin , Efird Jimmy T. 
Published: May 2024

AbstractInfectious etiologies have previously been proposed as causes of both melanoma and non‐melanoma skin cancer. This exploratory overview explains and presents the evidence for the hypothesis that a microorganism excreted in infected ruminant animal feces, Mycobacterium avium subspecies paratuberculosis (MAP), is the cause of some cases of cutaneous melanoma (CM). Occupational, residential, and recreational contact with MAP‐contaminated feces, soil, sand, and natural bodies of water may confer a higher rate of CM. Included in our hypothesis are possible reasons for the differing rates and locations of CM in persons with white versus nonwhite skin, why CM develops underneath nails and in vulvar skin, why canine melanoma is an excellent model for human melanoma, and why the Bacille Calmette‐Guérin (BCG) vaccine has demonstrated efficacy in the prevention and treatment of CM. The pathogenic mechanisms and etiologic aspects of MAP, as a transmittable agent underlying CM risk, are carefully deliberated in this paper. Imbalances in gut and skin bacteria, genetic risk factors, and vaccine prevention/therapy are also discussed, while acknowledging that the evidence for a causal association between MAP exposure and CM remains circumstantial.
Postoperative Cosmetic Scores and Revision Rates After Nasal Mohs Reconstructive Surgery
Authors: Sharma Rahul K. , DeSisto Nicole G. , Longino Elizabeth S. , Stephan Scott J. , Patel Priyesh N. , Yang Shiayin F. 
Published: May 2024

AbstractObjectiveFew studies have examined the impact of preoperative and surgical factors on the change in cosmetic survey scores after nasal Mohs reconstruction using a subset of the 10‐item Standardized Cosmesis and Health Nasal Outcomes Survey‐Cosmesis (SCHNOS‐C). We aim to determine preoperative and surgical factors that impact cosmetic outcomes following Mohs nasal reconstruction.Study DesignRetrospective analysis.SettingNasal Mohs reconstruction patients at a tertiary medical center.MethodsAll patients receiving Mohs reconstruction of any nasal subunit at a tertiary medical center were analyzed. Variables collected included demographic and Mohs defect/reconstruction characteristics. Primary outcomes were changes in cosmetic (SCHNOS‐C) scores and revision rates. Multivariable analysis was used to identify independent predictors of cosmetic scores/revision.ResultsWe included 296 patients for analysis. On multivariable logistic regression, factors contributing to better final cosmetic scores were receiving a skin/composite graft (odds ratio [OR]: 0.22, 95% confidence interval: 0.06‐0.68, P = .014) compared to a local flaps. Women were more likely to have worsening cosmetic scores (OR: 2.27, 1.06‐4.99, P = .037). Only initial cosmetic scores independently predicted receiving any revision (OR: 1.11, 1.03‐1.20, P = .006).ConclusionAverage SCHNOS‐C scores after nasal reconstruction of Mohs defects are low. Only worse patient reported SCHNOS‐C scores predicted revision. It is important to understand preoperative and surgical factors that affect cosmetic outcomes to optimize patient counseling and reconstructive planning. Patient perception is a key factor in predicting revisions.
A short banana fiber—PLA filament for 3D printing: Development and characterization
Authors: P.P Mohamed Shafeer , Pitchaimani Jeyaraj , Doddamani Mrityunjay 
Published: May 2024

AbstractThis study aims to develop a 3D printable composite filament using short banana fiber and polylactic acid (PLA). The filament was acquired through a single screw extruder, employing various blending techniques. Various fiber loadings were examined, impacting PLA's mechanical, thermal, and printability properties. The results revealed altered mechanical characteristics, with reduced tensile and flexural properties compared with pure PLA. However, these values are at an acceptable level for non‐structural applications. Compared with previous works, the filament developed in the present work is found out to be second strongest among the cellulose fiber‐reinforced PLA filaments. 3D printing with the composite filament encountered no significant issues. A modified mixing method improved mechanical characteristics, although 3D‐printed samples showed deteriorated mechanical characteristics due to poor interfacial bonding. This research introduces an environmentally viable strategy for advancing 3D printing technology by integrating banana fibers into PLA filament. The proposed strategy can be effectively utilized in making cellulose/PLA filaments for 3D printing applications. This innovative approach preserves PLA's natural biodegradability while carefully managing the integration of banana fibers and their potential effects on mechanical properties.Highlights
Fiber loading influences mechanical, with minimal impact on thermal properties.
Solution casting improved fiber/matrix bonding and filler homogeneity.
Plasticizing effect reduces the tensile strength.
Modified mixing resulted in even filament diameter and improved tensile properties.
Experimental design approach for the quantitative analysis of multicomponents by single marker and HPLC fingerprinting of Thunbergia laurifolia aqueous extract
Authors: Onsawang Thanapat , Suwanvecho Chaweewan , Sithisarn Pongtip , Phechkrajang Chutima , Rojsanga Piyanuch 
Published: May 2024

AbstractIntroductionThunbergia laurifolia is used in traditional Thai medicine to reduce fever and treat mouth ulcers. However, the quantitative analysis of chemical markers has not yet been officially defined.ObjectiveThe objective of this study is to develop a high‐performance liquid chromatography (HPLC) method using a design of experiment (DoE) for the quantitative analysis of multicomponents by single marker (QAMS) and fingerprinting of the T. laurifolia aqueous extract.Materials and MethodsCritical variables were screened using a two‐level fractional factorial design, followed by the optimization of the selected variables using a central composite design. The validated method was applied for quality assessment based on QAMS and fingerprinting of the extract.ResultsOptimum conditions of DoE for the analysis of caffeic acid, vicenin‐2, and rosmarinic acid were determined. The relative correction factors for caffeic acid and vicenin‐2 were calculated using rosmarinic acid as an internal reference standard, and their contents in 30 samples were determined. The differences between the external standard method (ESM) and QAMS were compared. No significant difference was observed in the quantitative determination, proving the consistency QAMS and ESM. HPLC fingerprints of T. laurifolia were established with 8 of 12 characteristic peaks that were structurally characterized using HPLC‐diode array detection‐electrospray ionization/tandem mass spectrometry. The similarity of the fingerprints in all samples was ≥0.74, and the pattern recognition of the characteristic peaks was satisfied.ConclusionThe proposed method efficiently detected multiple components of the T. laurifolia extract. Thus, the method is beneficial in providing references for enhancing the quality control of other herbal medicines.
Investigation of the influence of nano ZnO particle doping in electrode membrane on the output characteristics of biomimetic artificial muscles
Authors: Ji Yingxin , Wang Keyi , Zhao Gang 
Published: May 2024

AbstractBiomimetic artificial muscles (BMAMs) aim to imitate the movement and capabilities of natural muscles, drawing inspiration from their structure and function. This research utilized multiwalled carbon nanotubes to increase the conductivity of the electrode membrane and replaced traditional electroactive polymers with sodium alginate to improve the output performance of BMAMs. To further strengthen the output force of the electrode membrane, nanoscale ZnO was chosen as the doping material. Various composite electrode membranes were created during the experiments, each containing varying amounts of ZnO nanoparticles. The membranes' surface morphology was extensively examined with scanning electron microscopy, and the composite electrode membranes were fully assessed on an electrochemical workstation. Electrochemical testing showed that adding nanoscale ZnO particles greatly boosted the specific capacitance of the electrode membrane, which was directly linked to the performance of BMAMs. Impedance spectroscopy test results indicated a minimal impact of nanoscale ZnO particle doping on the internal resistance of the electrode membrane.Highlights
Sodium alginate replaces electroactive polymers, easing environmental impact.
Nano ZnO doping boosts electrode membrane's capacitance for stronger muscles.
ZnO doping shows minimal effect on electrode membrane's resistance.
(Thermo)mechanical and chemical characteristics of photochemically crosslinked acrylates from bio‐ and fossil‐based origin
Authors: Samyn Pieter , Adeel Muhammad , Pazdur Lukasz , Billen Pieter 
Published: May 2024

AbstractThe acrylates with oligomers and monomers from (partially) bio‐based feedstock become available at (semi‐)industrial scale, which can be processed through photochemical crosslinking for applications in coatings, additive manufacturing, electronics, or inks. Although fossil‐ and bio‐based acrylates may have a similar chemical composition, it requires good understanding of processing and structure–property relationships as minor changes in microstructure may strongly alter the performance. A comparative study on mechanical properties and chemical structure of bio‐ and fossil‐based acrylates with different functionalities and backbone structures reveals higher ductility of bio‐based acrylates, in relation with a more complex organization of the intrinsic molecular structure. The latter is confirmed by mechanical testing and visco‐elastic characteristics (dynamic mechanical analysis) yielding lower stiffness and higher dampening of bio‐based acrylates, in parallel with a lower glass transition temperature (differential scanning calorimetry). The complex molecular arrangements include a nanoscale morphology with ordered structure (X‐ray diffraction), conformational changes (infrared spectroscopy), and a residual high‐molecular weight fraction (size exclusion chromatography). The visco‐elastic calculations indicate only 4% to 5% lower crosslinking density and around 10% higher mean molar mass of the polymer chains segments between chemical crosslinks and trapped chain entanglements, which explain the unique structure and performance of bio‐based acrylates.
Trinitroethyl hydrazides of dicarbonic acids – Energetic compounds with high oxygen and nitrogen content
Authors: Klapötke Thomas M. , Krumm Burkhard , Riedelsheimer Christian 
Published: May 2024

AbstractMany currently used energetic materials need to be replaced with new compounds due to toxicity or other drawbacks. Among these is the oxidizer ammonium perchlorate, often used in solid state propellants, which itself, as well as its combustion products, poses health and environmental issues. Herein, three new polynitro energetic compounds are presented containing trinitroethyl moieties. Starting from easily available starting materials, such as malonic acid ethylester, diglycolic and diaminodiacetic acid, simple and straightforward syntheses were performed to obtain first the corresponding hydrazides and subsequently the trinitroethyl hydrazides in good yields and high purity. These compounds have a positive oxygen balance (assuming to the formation of CO), a high oxygen and nitrogen content and moderate densities. Full characterization was performed by NMR spectroscopy, vibrational analysis and elemental analysis. By using the Gaussian program package, the heats of formation were calculated and the energetic parameters were estimated utilizing the EXPLO5 computer code.
Research on the thermal runaway characteristics and risks of square soft lithium‐ion batteries nail penetration
Authors: Wang Jun , Wang Le , Pan Renming , Zhou Xia 
Published: May 2024

AbstractTo conduct a comprehensive investigation into the nail penetration thermal runaway (TR) characteristics of 16 Ah/5 Ah lithium‐ion batteries (LIBs) and their modules. The study aims to analyze the burst characteristics and examine the variations in TR behavior under specific conditions, with the goal of improving early warning and protection against LIB TR incidents. The research findings demonstrate that mechanical nail penetration can rapidly trigger TR, resulting in the highest temperature 522.3°C within 51.9 s, and the fastest is 20 s. In the case of LIB modules, a secondary temperature rise occurs, exhibiting an increased rate of up to 77%. Notably, when the battery bulges, there is a release of high‐temperature two‐phase heat flow accompanied by a significant discharge of combustible gases. This escalation increases the risk of further explosions. Moreover, the study observes repeated spray fires and the generation of a considerable amount of smoke. Additionally, the study highlights the role of sudden rise in temperature and the release of H2 as early indicators of TR. These findings provide valuable theoretical insights into the characteristics and risks of square soft LIBs, enhance safety measures, and contribute to the development of early warning systems for LIBs.
Front Cover Image
Authors: Peirce Erika S , Evers Byron , Winn Zachary J , Raupp W John , Guttieri Mary , Fritz Allan K , Poland Jesse , Akhunov Eduard , Haley Scott , Mason Esten , Nachappa Punya 
Published: May 2024

The cover image is based on the Research Article Identifying novel sources of resistance to wheat stem sawfly in five wild wheat species by Erika S Peirce et al., https://doi.org/10.1002/ps.8008.
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Heat stress‐induced oviposition behavioral change correlates with sperm damage in the pine sawyer beetle, Monochamus alternatus
Authors: Li Hui , Li Shouyin , Chen Jin , Tan Yushan , Ye Jianren , Hao Dejun 
Published: May 2024

AbstractBackgroundGlobal climate change is causing an increase in extreme high temperatures (EHTs), which subject insects to unprecedented stress. Behavior plasticity in response to EHTs, particularly oviposition behavior, is important for the persistence and outbreak of insect populations. Investigating the plasticity of oviposition behavior and its underlying mechanisms has theoretical importance to pest management, but knowledge gaps still remain.ResultsHerein, we characterized the reproductive traits of Monochamus alternatus, a dominant insect vector of the destructive pine wilt disease, including oviposition behavioral patterns, fecundity, offspring fitness and sperm viability, under simulated heatwave conditions in the laboratory. The results showed that (i) EHTs induced a novel oviposition behavior, whereby females deposited multiple eggs into a single groove rather than laying one egg per groove under normal condition; (ii) EHTs exerted stage‐ and sex‐specific effects on fecundity, offspring fitness and sperm viability; and (iii) there was a significant correlation between frequency of the novel oviposition strategy and sperm viability.ConclusionWe hypothesized that this beetle pest has the ability to flexibly shift towards a low‐cost oviposition strategy to counteract the fitness costs caused by heat stress. Taken together, these findings provide a theoretical foundation for personalized pest management strategies in the context of climate change. © 2024 Society of Chemical Industry.
Educators' invisible labour: A systematic review
Authors: Staudt Willet K. Bret , He Dan 
Published: May 2024

AbstractThe hidden or overlooked nature of many of educators' professional activities complicates the already difficult task of supporting educators' labour—in both K‐12 and higher education settings. These efforts can be understood as types of invisible labour. Following PRISMA standards, we conducted a systematic literature review to answer a single research question: How have scholars framed educators' professional activities in terms of invisible labour? This systematic review searched 10 educational databases and identified 16 peer‐reviewed journal articles spanning 2011–2021. From thematic analysis of these studies, we developed a model of five types of invisibility that intersect and mask educators' professional efforts: background, care, precarious, identity and remote labour. The review also showed several overall themes related to educators' invisible labour, which we discuss in connection to the literature: effort is often semivisible, invisibility is subjective, effort by marginalised educators is often overlooked, labour in unexpected places often means effort is overlooked, and there are layers of factors masking effort. We then discuss implications for practice, starting with five invisible labour questions to prompt reflection, then how to apply invisible labour as an improvement lens for identifying needs, allocating resources, analysing jobs and tasks, and evaluating performance.