bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immune checkpoint inhibitors and pericardial disease: a systematic review
Authors: Mudra Sarah E. , Rayes Danny L. , Agrawal Ankit , Kumar Ashwin K. , Li Jason Z. , Njus Meredith , McGowan Kevin , Kalam Kazi A. , Charalampous Charalompos , Schleicher Mary , Majid Muhammad , Syed Alvena , Yesilyaprak Abdullah , Klein Allan L. 
Published: May 2024

Abstract
Introduction
Despite the growing use of immune checkpoint inhibitors (ICI) in cancer treatment, data regarding ICI-associated pericardial disease are primarily derived from case reports and case series. ICI related pericardial disease can be difficult to diagnose and is associated with significant morbidity. We conducted a systematic review to further characterize the epidemiology, clinical presentation, and outcomes of this patient population.

Methods
A search of four databases resulted in 31 studies meeting inclusion criteria. Patients > 18 years old who presented with ICI mediated pericardial disease were included. Intervention was medical + surgical therapy and outcomes were development of cardiac tamponade, morbidity, and mortality.

Results
Thirty- eight patients across 31 cases were included. Patients were majority male (72%) with a median age of 63. Common symptoms included dyspnea (59%) and chest pain (32%), with 41% presenting with cardiac tamponade. Lung cancer (81%) was the most prevalent, and nivolumab (61%) and pembrolizumab (34%) were the most used ICIs. Pericardiocentesis was performed in 68% of patients, and 92% experienced symptom improvement upon ICI cessation. Overall mortality was 16%.

Discussion
This study provides the most comprehensive analysis of ICI-mediated pericardial disease to date. Patients affected were most commonly male with lung cancer treated with either Nivolumab or Pembrolizumab. Diagnosis may be challenging in the setting of occult presentation with normal EKG and physical exam as well as delayed onset from therapy initiation. ICI-associated pericardial disease demonstrates high morbidity and mortality, as evidenced by a majority of patients requiring pericardiocentesis.
Effect of Maitland mobilization versus deep cervical flexors muscles training on proprioception in adults with chronic mechanical neck pain: a randomized controlled trial
Authors: Amin Fatma Sadeek , Abdel-Aal Nabil Mahmoud , El Shater Ban Saleh 
Published: May 2024

AbstractObjectiveTo examine the effect of adding Maitland mobilization (MM) versus deep cervical flexors muscles training (DCFMT) to conventional physical therapy (CPT) on proprioception in adults with chronic mechanical neck pain (CMNP).Materials and methodsA randomized controlled study was carried out at the outpatient clinics of physical therapy at Cairo and Suez universities. Sixty participants (27 males, 33 females) with CMNP were randomized into 3 equivalent groups. Group I received MM plus CPT, group II received DCFMT in addition to CPT, and group III received CPT only. All individuals were given three sessions a week for 4 weeks. The primary outcomes were proprioception (CROM), and pain (VAS). The secondary outcomes were cranio-vertebral angle (CVA), and upper cervical angle (C0–C2). Outcomes were evaluated at baseline and following 4 weeks of treatment.ResultsFollowing 4 weeks of treatment, the DCFMT group showed statistically significant improvement to the MM group as well as the CPT group in all outcome measures (p > 0.05). Also, the MM group was remarkably better than the CPT group in all measured outcomes (p > 0.05). The mean signed difference (M±SD) post-treatment within the group of VAS were 6.87 ± 1.26, 7.15 ± 1.38, and 7.20 ± 1.39 cm for MM, DCFMT, and CPT groups respectively. The (M±SD) of CVA were 42.61 ± 4.36, 42.24 ± 3.64, and 42.32 ± 4.81 degrees for MM, DCFMT, and CPT groups respectively. The (M±SD) of C0–C2 were 24.25 ± 2.98, 23.37 ± 1.94, and 24.95 ± 3.01 degrees for MM, DCFMT, and CPT groups respectively. The (M±SD) of flexion JPE to target were 3.62 ± 0.91, 2.86 ± 0.77, and 4.35 ± 0.91 degrees for MM, DCFMT, and CPT groups respectively. The (M±SD) of flexion JPE to neutral were 3.96 ± 0.78, 2.66 ± 1.03, and 5.23 ± 1.52 degrees for MM, DCFMT, and CPT groups respectively.ConclusionAdding MM and DCFMT to CPT revealed significant enhancement, favoring DCFMT, on proprioception, pain, cranio-vertebral angle (CVA), upper cervical angle (C0–C2), and intensity than CPT alone in adults with CMNP.Trial registrationPan African Clinical Trails Registry with a registration No. PACTR202211651838599 on the 3rd of November 2022.
Investigation of the epidemiology, pathogenicity and immunogenicity of Bordetella bronchiseptica isolated from cats and dogs in China from 2021 to 2023
Authors: Shang Qinghua , Gao Wenhui , Zhang Xiangting , Zhao Jianqing , Wu Ying , Li Haoqi , Zhou Ming , Fu Zhen F. , Zhang Chengguang , Zhao Ling 
Published: May 2024

AbstractBordetella bronchiseptica (Bb) is recognized as a leading cause of respiratory diseases in dogs and cats. However, epidemiological data on Bb in dogs and cats in China are still limited, and there is no commercially available vaccine. Live vaccines containing Bb that are widely used abroad are generally effective but can establish latency and potentially reactivate to cause illness in some immunodeficient vaccinated recipients, raising safety concerns. In this study, 34 canine-derived and two feline-derived Bb strains were isolated from 1809 canine and 113 feline nasopharyngeal swab samples collected from eight provinces in China from 2021 to 2023. The PCR results showed that the percentage of positive Bb was 22.94% (441/1922), and more than 90% of the Bb isolates had four virulence factor-encoding genes (VFGs), namely, fhaB, prn, betA and dnt. All the isolated strains displayed a multidrug-resistant phenotype. The virulence of 10 Bb strains isolated from dogs with respiratory symptoms was tested in mice, and we found that eight isolates were highly virulent. Furthermore, the eight Bb isolates with high virulence were inactivated and intramuscularly injected into mice, and three Bb strains (WH1218, WH1203 and WH1224) with the best protective efficacy were selected. Dogs immunized with these three strains exhibited strong protection against challenge with the Bb field strain WH1218. Ultimately, the WH1218 strain with the greatest protection in dogs was selected as the vaccine candidate. Dogs and cats that received a vaccine containing 109 CFU of the inactivated WH1218 strain showed complete protection against challenge with the Bb field strain WH1218. This study revealed that Bb is an important pathogen that causes respiratory diseases in domestic dogs and cats in China, and all the isolates exhibited multidrug resistance. The present work contributes to the current understanding of the prevalence, antimicrobial resistance, and virulence genes of Bb in domestic dogs and cats. Additionally, our results suggest that the WH1218 strain is a promising candidate safe and efficacious inactivated Bb vaccine.
Significance of QTc Interval in Chronic Hypoparathyroidism and its Correlates
Authors: Namjoshi Preeti , Saha Soma , Sharma Vibhav , Kalaivani Mani , Narang Rajiv , Goswami Ravinder 
Published: May 2024

Abstract

Context
Hypocalcemia predisposes patients with chronic hypoparathyroidism (cHypoPT) to an increased risk of QTc prolongation and life-threatening arrhythmias. Information on clinical and biochemical correlates of QTc in cHypoPT is limited.

Objective
To assess the significance of QTc interval in chronic hypoparathyroidism and its correlates.

Methods
This was an observational cohort study at a tertiary care center. Eighty-eight nonsurgical patients with cHypoPT (mean age 44.1 ± 15.4 years, 45 males) were assessed for QTc interval and its possible correlates including arrhythmic symptoms (palpitation/giddiness/syncope), serum total calcium, phosphate, 25(OH)D, and intact parathyroid hormone.

Results
The mean QTc in the HypoPT cohort was 428 ± 34 ms with 13.6% having prolonged QTc. There was a significant inverse correlation between QTc interval and serum total calcium measured on the same day (r = −0.43, P &lt; .001). The mean serum total calcium was significantly lower in patients with prolonged QTc (7.05 ± 1.94 vs 8.49 ± 1.01 mg/dL, P = .02). Of patients with cHypoPT 21.6% had arrhythmic symptoms. They had significantly higher mean QTc (P = .02) and also tended to have lower mean serum total calcium during follow-up (P = .06). In multivariable regression, female gender, higher current age, higher body mass index, and low serum total calcium showed significant association with prolonged QTc. For every mg/dL decrease in serum total calcium, QTc increased by 13 ms. Receiver operating characteristic analysis revealed serum total calcium at cut-off of 8.3 mg/dL discriminated prolonged QTc with area under the curve being 0.72 (95% CI 0.51, 0.93).

Conclusion
One-fifth of patients with cHypoPT had arrhythmic symptoms and a significant proportion had prolonged QTc. This highlights the need for close monitoring of patients with cHypoPT for arrhythmic symptoms and QTc prolongation. The serum total calcium should be maintained to at least 8.3 mg/dL to minimize the risk of potentially life-threatening arrhythmia in cHypoPT.
Hybrid Baihua 白話 as a Third Space: East Asian Anticolonial Writing in Modern China
Authors: Lin Chai , Dongmei Li 
Published: May 2024

Abstract
After the colonial invasion of East Asia, numerous Koreans, Vietnamese, and Japanese went to China and began a long anticolonial struggle. During this period, they chose to write and communicate in a fourth language, Baihua 白話, for anticolonial purposes. While writing in Baihua, they brought the grammar and word order of their mother tongues into Baihua, creating “Korean-style vernacular Chinese,” “Japanese-style vernacular Chinese,” and “Vietnamese-style vernacular Chinese.” The emergence of these hybridized Baihuas is related to the anticolonialists’ cooperation with the Kuomintang government, the oppression of the Kuomintang government, and the authority of Literary Sinitic and Baihua. As a form of subversion of and resistance to the authority of Literary Sinitic and Baihua, the hybrid Baihuas thus constructed served as an anticolonial third space.
Acute Vigorous Exercise Decreases Subsequent Nonexercise Physical Activity and Body Temperature Linked to Weight Gain
Authors: FUNABASHI DAISUKE , DOBASHI SHOHEI , SAMESHIMA KAZUKI , SAGAYAMA HIROYUKI , NISHIJIMA TAKESHI , MATSUI TAKASHI 
Published: May 2024

ABSTRACT

Purpose
Exercise benefits the body and mind, but its weight loss effect is less than generally expected. Although this phenomenon is likely due to an exercise intensity–dependent decrease in non-exercise physical activity (NEPA), resulting in a decrease in non-exercise activity thermogenesis, the underlying mechanisms and effects of exercise intensity remain unknown. Here we show that acute vigorous exercise decreases subsequent NEPA and body temperature (BT) in association with body weight gain.

Methods
Adult male C57BL/6J mice were categorized into three groups: sedentary, moderate exercise, and vigorous exercise, with exercise groups undergoing a 30-min treadmill session. Using an intraperitoneally implanted activity monitor, NEPA and BT were monitored for 2 d before and 3 d after exercise. The daily synchrony between NEPA and BT was evaluated using a cross-correlation function. Plasma corticosterone was also detected 6 and 24 h after exercise.

Results
Notably, only the vigorous exercise group exhibited a decline in both NEPA and BT, resulting in body weight gain the following day, despite no observed changes in food intake. Furthermore, vigorous exercise induces a distinct delay in the daily dynamics of NEPA compared with BT. A positive correlation was observed between plasma corticosterone levels and changes in NEPA levels before and after exercise across all exercise groups.

Conclusions
Our findings provide evidence for vigorous exercise–specific reduction in subsequent NEPA, BT, and their synchrony linked to weight gain, likely due to the disturbed circadian rhythm of corticosterone. This is an initial investigation redefining the significance of exercise intensity in beneficial effects beyond the energy expenditure of the exercise itself.
Neoplatonic and Gnostic Resonances in the Martyrdom of Cyprian of Athenais Eudocia
Authors: Dendrinos Markos , Griva Anna 
Published: May 2024

Aelia Eudocia Augusta (formerly Athenais), wife of the emperor Theodosius II, lives at the borderline between the ancient and the Christian world and writes one of the most distinctive poetic texts of Byzantine literature. In the Martyrdom of Cyprian, written in Homeric language, the Saint's past, when he was a magician and initiated into a multitude of Greek mysteries, is presented in an original and remarkable way. Within this text, the resonance of philosophical ideas originating from Neoplatonism and Gnosticism is of particular interest. This article attempts to highlight these resonances in order to open a research dialogue regarding the complex network of ideas and the coexistence of different worldviews in early Byzantium.
Parallels between Maximus the Confessor and Vladimir Soloviev (1853-1900)
Authors: Zacharia Paraskevi 
Published: May 2024

The philosophical thought of Vladimir Soloviev (1853-1900) does not appear to significantly abstain from the wholeness of humanity and the deification of human being that Maximus synthesises. In Maximus’ writings Christology is strongly bounded to love, under the soteriological meaning of Christ’s Incarnation. In Soloviev’s philosophical thought love plays the role of the cosmic power which, by transcending the historical process, leads the humanity to the deification. This paper aims at the exegesis of the three-fold nature of love (love for one’s brothers, and self-love) in Maximus’ works, while discussing the points of convergence with Soloviev’s ontology of love in Smysl lyubvi (The Meaning of Love) (1892-1894).
Lactase Deficiency and Lactose Intolerance: Current Understanding and Future Directions
Authors: Rachwał Krystian , Wielgus Karol , Bator Piotr , Razik Wiktor , Łyko Grzegorz , Antos Maria , Furgalska Julia , Pawłowska Maria , Wawryszuk Angelika 
Published: May 2024

Introduction and purpose: Lactose, the primary carbohydrate in milk, requires the enzyme lactase for digestion. Deficiency in lactase activity leads to lactose intolerance, causing gastrointestinal symptoms. Understanding the genetic and environmental factors influencing lactase expression and activity is crucial. Moreover, accurate diagnostic methods and effective treatments are needed to manage lactose intolerance. This review aims to explore the current knowledge on lactase deficiency, lactose intolerance, diagnostic methods, and treatment options. State of knowledge: Lactase deficiency encompasses congenital, primary, and secondary forms, each with distinct etiologies. Although often used interchangeably, lactase deficiency and lactose intolerance differ. However, the association between lactase deficiency and lactose intolerance is complex, influenced by various factors including dietary habits, gut microbiota, and gastrointestinal motility. Diagnostic methods are limited, and treatment strategies primarily involve dietary modifications, lactase supplementation, and probiotics. Conclusion: Lactose intolerance presents significant clinical challenges, often underrecognized and misdiagnosed. Despite diagnostic advancements further research is needed to refine diagnostic accuracy. Treatment focuses on dietary adjustments, enzyme supplementation, and probiotics. Balancing symptom relief with nutritional adequacy is essential. Future studies should explore the role of gut microbiome modulation in lactose intolerance management through clinical trials.
Address Terms Used in Discount Account Found in Instagram
Authors: Giyatmi Giyatmi - , Astuti Purwani Indri 
Published: May 2024

Addressing the customer is one way to attract the interest of the customers as well as to build intimacy with them. This study aims at describing the types of address terms used in discount account in Instagram. This research is classified as a descriptive qualitative research because it observes the address terms used by discount account in Instagram. The data of the study are the address terms found in discount accounts in Instagram. The writers use three account discounts in Instagram such as; @giladiskonn https://www.instagram.com/giladiskonn/#, @diskondijogja https://www.instagram.com/diskondijogja/, @info_diskon https://www.instagram.com/info_diskon/. To collect the data, the writers use documentation. The technic of data analysis consists of four steps such as data collection, data reduction, data display, and conclusion. The research found 37 address terms used by discount accounts in Instagram. Next, they are distributed into 4 types of address terms, namely Kinship address term (5), Pet name/nickname/special nick name (23), pronoun (2), and slang address term (7). Pet names/nicknames/special nicknames are the most dominant address terms used in discount accounts. The use of pet name/nicknames/special nicknames includes pet name with product names, pet names with company names, pet names with brands, pet names with account names. Pet name address terms are used to show close relation between buyers and sellers which is important in running online business. Meanwhile, the least address terms used in discount account is pronoun.
Fenomena LGBT di Indonesia dan Jepang dalam Perspektif Wacana Seksualitas dan Kekuasaan Michel Foucault
Authors: Nurdiniyah Hayun , Dehars Rizky Aurelia Putri 
Published: May 2024

Penelitian ini bertujuan untuk mengidentifikasi keberadaan kaum LGBT antara Indonesia dan Jepang melalui wacana seksualitas dan kekuasaan Michel Focault. Penelitian ini merupakan penelitian bersifat kualitatif dengan metode yang digunakan adalah studi kepustakaan. Sumber data utama yang digunakan dalam penelitian ini adalah buku, jurnal penelitian ilmiah dan artikel yang berkaitan dengan LGBT di Indonesia dan Jepang. Hasil penelitian ini menunjukkan bahwa di Indonesia gerakan LGBT tetap eksi bahkan para sastrawan mulai aktif menghasilkan karya bertemakan LGBT di tengah berbagai macam aturan normatif keagamaan, khususnya setelah masa Orde Baru runtuh. Sedangkan di Jepang, gerakan LGBT lebih mengedepankan pada program-program kesehatan seperti pencegahan HIW/AIDS, Selain itu, perkembangan karya sastra yang bertemakan homoseksual sudah ada sejak era Tokugawa dan semakin berkembang hingga saat ini dengan munculnya genre karya sastra Boys Love dan Girls Love, dan terlebih lagi sistim keagamaan di Jepang tidak sekuat di Indonesia dalam mengatur orientasi seksual seseorang. Namun, dewasa ini baik di Indonesia maupun Jepang, masyarakat mulai mengedepankan sikap kritis dalam menghadapi fenomena LGBT ini.
The semiotic phenomenology of inverse alteroception
Authors: Pelkey Jamin 
Published: May 2024

Abstract
Alteroception is the virtual experience of another person’s bodily movement centered in the perspective of the other person. In face-to-face interactions, human beings tend to assume a special mode of alteroception by mutually but tacitly recognizing that ‘your right is on my left and your left is on my right’. Researchers of neonatal cognition and early childhood development describe this mode of alteroception as “reverse” or “inverted”. Inverse alteroception goes beyond mirror-image mimesis to chiastic (crisscrossing) mimesis in acts of intersubjective sense-making; but the cognitive and cultural affordances of this inverse reciprocal ability are largely untreated in the literature. I argue that this unique aspect of human phenomenology deserves closer attention since it enables a broader palette of diagrammatic contrasts that extend far beyond face-to-face interaction. In this paper, I apply insights from Peircean and Greimasian semiotics to argue that salient features of the human lifeworld originate from imaginative mappings of inverse alteroception onto other domains. From diagrams of gesture space and contemporary visual design to the structures of the Proscenium stage, from historic heraldry to Aristotle’s logical square of oppositions and beyond, many visual/spatial designs and their reciprocal interaction with human experience are linked to this ability – an ability that owes its origins, in turn, to the evolution of upright posture.
Using a reverse life plot for estimating fatigue endurance/limit
Authors: Kujawski Daniel , Vasudevan Asuri K. , Plano Stefano , Gabellone Davide 
Published: May 2024

Abstract
This short review paper describes the use of a reverse life plot, σ

a
versus 1/N

f
, for estimating a fatigue endurance/limit, σ
FL. The method is applicable for different alloy-environment systems and load R-ratios. Due to inherent scatter in the fatigue data approaching fatigue limit, a ‘staircase’ method is often utilized that requires relatively large number of specimens (around 15–30) to be tested just for fatigue endurance/limit determination alone. The proposed method uses only high-cycle-fatigue (HCF) S-N data. The estimated fatigue endurance/limit is verified against the data from staircase method for 7000 Al alloy in air and corrosive 0.5 % NaCl solution environment. The comparison with the staircase method shows fairly good agreement. An additional example shows how this method estimates endurance limits for 4140 steels tested in three environments: dry air, air with 93 % RH, and aerated 3 % NaCl solution.
Impact of thermosonication treatment on passion fruit juice: ANN/GA optimization, predictive modelling for shelf life and quality changes during storage
Authors: Chutia Hemanta , Begum Fogila , Rohilla Shubham , Mahanta Charu Lata 
Published: May 2024

Abstract
Optimized sugar-added passion fruit juice (OPFJ) was obtained after optimization of thermosonication treatments of passion fruit juice using hybrid Artificial neural network/Genetic algorithm. The quality parameters and shelf life of OPFJ stored at various temperatures were assessed. Baranyi and Ratkowsky’s square-root models proved the prediction accuracy of the theoretical model concerning the microbial population during storage. The lag phase value decreased with increasing storage temperature. Temperature rise from 8 to 25 °C decreased the shelf life from 17 to 8 days for OPFJ and 3.5 to 1.5 days for untreated juice. The activation energy and increase in the reaction rate on increase in temperature by 10 °C (Q
10 value) were also evaluated. Thermosonication increased the phenolic and β-carotene contents and maintained the pH, titratable acidity, ascorbic acid content, and antioxidant activity during storage. Thermosonication enhanced the quality and shelf life of juice. Predictive modelling effectively predicted the shelf life.