bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensitivity of Heavy Precipitation Forecasts to Small Modifications of Large-Scale Weather Patterns for the Elbe River
Authors: Schlüter Ingo , Schädler Gerd 
Published: February 2010

Abstract
Extreme flood events are caused by long-lasting and/or intensive precipitation. The detailed knowledge of the distribution, intensity, and spatiotemporal variability of precipitation is, therefore, a prerequisite for hydrological flood modeling and flood risk management. For hydrological modeling, temporal and spatial high-resolution precipitation data can be provided by meteorological models. This study deals with the question of how small changes in the synoptic situation affect the characteristics of extreme forecasts. For that purpose, two historic extreme precipitation events were hindcasted using the Consortium for Small Scale Modeling (COSMO) model of the German Weather Service (DWD) with different grid resolutions (28, 7, and 2.8 km), where the domains with finer resolutions were nested into the ones with coarser resolution. The results show that the model is capable of simulating such extreme precipitation events in a satisfactory way. To assess the impact of small changes in the synoptic situations on extreme precipitation events, the large-scale atmospheric fields were shifted to north, south, east, and west with respect to the orography by about 28 and 56 km, respectively, in one series of runs while in another series, the relative humidity and temperature were increased to modify the amount of precipitable water. Both series were performed for the Elbe flood events in August 2002 and January 2003, corresponding to two very different synoptic situations. The results show that the modeled precipitation can be quite sensitive to small changes of the synoptic situation with changes in the order of 20% for the maximum daily precipitation and that the types of synoptic situations play an important role. While van Bebber weather conditions, of Mediterranean origin, were quite sensitive to modifications, more homogeneous weather patterns were less sensitive.
Near-Inertial Wave Wake of Hurricanes Katrina and Rita over Mesoscale Oceanic Eddies
Authors: Jaimes Benjamin , Shay Lynn K. 
Published: February 2010

Abstract
Tropical cyclones (TCs) Katrina and Rita moved as major hurricanes over energetic geostrophic ocean features in the Gulf of Mexico. Increased and reduced oceanic mixed layer (OML) cooling was measured following the passage of both storms over cyclonic and anticyclonic geostrophic relative vorticity ζg, respectively. This contrasting thermal response is investigated here in terms of the evolution of the storms’ near-inertial wave wake in geostrophic eddies. Observational data and ray-tracing techniques in realistic geostrophic flow indicate that TC-forced OML near-inertial waves are trapped in regions of negative ζg, where they rapidly propagate into the thermocline. These anticyclonic-rotating regimes coincided with the distribution of reduced OML cooling because rapid downward dispersion of near-inertial energy reduced the amount of kinetic energy available to increase vertical shears at the OML base. By contrast, TC-forced OML near-inertial waves were stalled in upper layers of cyclonic circulations, which strengthened vertical shears and entrainment cooling. Upgoing near-inertial energy propagation dominated inside a geostrophic cyclone that interacted with Katrina; the salient characteristics of these upward-propagating waves were the following: (i) they were radiated from the ocean interior because of geostrophic adjustment following upwelling–downwelling processes; (ii) rather than with the buoyancy frequency, they amplified horizontally as they encountered increasing values of f + ζg/2 during upward propagation; and (iii) they produced episodic vertical mixing through shear instability at a critical layer underneath the OML. To improve the prediction of TC-induced OML cooling, models must capture geostrophic features and turbulence closures must represent near-inertial wave processes such as dispersion and breaking between the OML base and the thermocline.
Performance of an Eddy Diffusivity–Mass Flux Scheme for Shallow Cumulus Boundary Layers
Authors: Angevine Wayne M. , Jiang Hongli , Mauritsen Thorsten 
Published: February 2010

Abstract
Comparisons between single-column (SCM) simulations with the total energy–mass flux boundary layer scheme (TEMF) and large-eddy simulations (LES) are shown for four cases from the Gulf of Mexico Atmospheric Composition and Climate Study (GoMACCS) 2006 field experiment in the vicinity of Houston, Texas. The SCM simulations were run with initial soundings and surface forcing identical to those in the LES, providing a clean comparison with the boundary layer scheme isolated from any other influences. Good agreement is found in the simulated vertical transport and resulting moisture profiles. Notable differences are seen in the cloud base and in the distribution of moisture between the lower and upper cloud layer. By the end of the simulations, TEMF has dried the subcloud layer and moistened the lower cloud layer more than LES. TEMF gives more realistic profiles for shallow cumulus conditions than traditional boundary layer schemes, which have no transport above the dry convective boundary layer. Changes to the formulation and its parameters from previous publications are discussed.
The Role of Atmospheric Conditions in Determining Intensity of Crepuscular and Anticrepuscular Rays
Authors: Van Den Broeke Matthew S. , Beasley William H. , Richman Michael B. 
Published: February 2010

Abstract
During the summer of 2006, daily observations of crepuscular and anticrepuscular rays were made around sunset from central Oklahoma. A relative scale of ray intensity was developed and used to relate the rays to concurrent meteorological conditions. Evidence is presented suggesting that both topography and clouds can cast shadows leading to rays. Relationships are hypothesized between estimated ray intensity and atmospheric variables, and predictive equations are developed for ray intensity and assessed using data from the summer of 2008. Except for a few cases in which rays were traced back to topography east of the Rocky Mountains, the most intense rays were produced by towering cumulus (Cu) and cumulonimbus (Cb) clouds to the west after hot days with light winds.
Visuo-proprioceptive training reduces risk of falls in patients with multiple sclerosis
Authors: Prosperini Luca , Leonardi Laura , De Carli Paolo , Mannocchi Maria Letizia , Pozzilli Carlo 
Published: February 2010

Lack of balance and falls are common and disabling symptoms of multiple sclerosis. The aim of this study was to investigate the effectiveness of a novel visuo-proprioceptive feedback training in ameliorating balance and reducing the risk of falls. Patients with multiple sclerosis with unrestricted walking ability and healthy age/sex-matched controls were recruited. After a baseline clinical evaluation, including a postural assessment in double- (stabilometric test) and single-leg stance (monopodalic test) by a computerized postural recorder device, patients were submitted to a run-in period lasting 6 weeks without any rehabilitative intervention. Two further clinical and postural evaluations before and after a 6-week period of training were performed. The training protocol provided static and dynamic exercises both in double- and single-leg stance, with and without a translating Freeman-like board. Visual feedback was shown on the computer screen during the exercises. We recruited 40 consecutive patients and 12 controls. Patients had significantly poorer postural performances than controls. Twenty-eight patients completed the study follow-up. No significant changes in risk of falls emerged after the run-in period. A significant reduction in the median percentage of risk of falls in single-leg stance (open eyes: 39.3 versus 15.7; closed eyes: 67.3 versus 52.6; p < 0.001, respectively) were observed after rehabilitation. Moreover, an improvement in walking speed (median time: 7.4 s versus 6.3; p = 0.001) was detected in the absence of Expanded Disability Status Scale changes. We conclude that visuo-proprioceptive training improves balance and reduces falls in multiple sclerosis.
Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching
Authors: Strasser Geraldine A. , Kaminker Joshua S. , Tessier-Lavigne Marc 
Published: February 2010

Abstract
The development of the vertebrate vascular system is mediated by both genetic patterning of vessels and by angiogenic sprouting in response to hypoxia. Both of these processes depend on the detection of environmental guidance cues by endothelial cells. A specialized subtype of endothelial cell known as the tip cell is thought to be involved in the detection and response to these cues, but the molecular signaling pathways used by tip cells to mediate tissue vascularization remain largely uncharacterized. To identify genes critical to tip cell function, we have developed a method to isolate them using laser capture microdissection, permitting comparison of RNA extracted from endothelial tip cells with that of endothelial stalk cells using microarray analysis. Genes enriched in tip cells include ESM-1, angiopoietin-2, and SLP-76. CXCR4, a receptor for the chemokine stromal-cell derived factor-1, was also identified as a tip cell-enriched gene, and we provide evidence for a novel role for this receptor in mediating tip cell morphology and vascular patterning in the neonatal retina.
Azithromycin induces anti-viral responses in bronchial epithelial cells
Authors: Gielen V. , Johnston S.L. , Edwards M.R. 
Published: February 2010

The majority of asthma exacerbations are caused by rhinovirus. Currently the treatment of asthma exacerbations is inadequate. Previous evidence suggests that macrolide antibiotics have anti-inflammatory and antiviral effects; however, the mechanism is unknown.We investigated the anti-rhinoviral potential of macrolides through the induction of antiviral gene mRNA and protein. Primary human bronchial epithelial cells were pre-treated with the macrolides azithromycin, erythromycin and telithromycin, and infected with minor-group rhinovirus 1B and major-group rhinovirus 16. The mRNA expression of the antiviral genes, type I interferon-β and type III interferon-λ1, interferon-λ2/3, and interferon-stimulated genes (retinoic acid inducible gene I, melanoma differentiation associated gene 5, oligoadenylate synthase, MxA and viperin) and pro-inflammatory cytokines (interleukin (IL)-6 and IL-8), and rhinovirus replication and release were measured.Azithromycin, but not erythromycin or telithromycin, significantly increased rhinovirus 1B- and rhinovirus 16-induced interferons and interferon-stimulated gene mRNA expression and protein production. Furthermore, azithromycin significantly reduced rhinovirus replication and release. Rhinovirus induced IL-6 and IL-8 protein and mRNA expression were not significantly reduced by azithromycin pre-treatment.In conclusion, the results demonstrate that azithromycin has anti-rhinoviral activity in bronchial epithelial cells and, during rhinovirus infection, increases the production of interferon-stimulated genes.
Impact of dietary shift to higher-antioxidant foods in COPD: a randomised trial
Authors: Keranis E. , Makris D. , Rodopoulou P. , Martinou H. , Papamakarios G. , Daniil Z. , Zintzaras E. , Gourgoulianis K.I. 
Published: February 2010

Chronic obstructive pulmonary disease (COPD) is characterised by increased oxidative stress. Dietary factors, such as ample consumption of foods rich in antioxidants, such as fruit and vegetables, might have beneficial effects in COPD patients.The association between dietary shift to foods rich in antioxidants and lung function in COPD was investigated in a 3-yr prospective study. A total of 120 COPD patients were randomised to follow either a diet based on increased consumption of fresh fruit and vegetables (intervention group (IG)) or a free diet (control group (CG)).The mean consumption of foods containing antioxidants was higher in the IG than in the CG throughout the study period (p<0.05). The relationship between consumption of foods rich in antioxidants and percentage predicted forced expiratory volume in 1 s was assessed using a general linear model for repeated measures; the two groups overall were different in time (p = 0.03), with the IG showing a better outcome. In investigating the effect of several confounders (sex, age, smoking status, comorbid conditions and exacerbation) of group response over time, nonsignificant interactions were found between confounders, group and time.These findings suggest that a dietary shift to higher-antioxidant food intake may be associated with improvement in lung function, and, in this respect, dietary interventions might be considered in COPD management.
Socioeconomic risk factors for lung function decline in a general population
Authors: Johannessen A. , Eagan T.M.L. , Omenaas E.R. , Bakke P.S. , Gulsvik A. 
Published: February 2010

The aim of our study was to examine sex-specific associations between different aspects of socioeconomic status (SES) (educational level, occupational status, income) and lung function in a general adult population.In the Hordaland County Cohort Study, 1,644 subjects aged 26–82 yrs at baseline answered questionnaires and performed post-bronchodilator spirometry both in 1996–1997 and in 2003–2006. We performed adjusted linear regression analysis on the effect of SES on decline in forced experimental volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC.Mean annual decline in FEV1from baseline to follow-up was 57 mL (se1.3) and 48 mL (se1.0) for males and females, respectively. Males had a larger decline in FVC than females, while females had a larger decline in FEV1/FVC. Lower education and low occupational status were associated with larger male lung function decline. SES did not affect female lung function decline. However, marital status was a significant predictor; unmarried females had less decline than both married and widowed females in both FEV1(adjusted mean annual difference 8 mL and 16 mL) and FVC (adjusted mean annual difference 8 mL and 18 mL).Low SES was associated with increased lung function decline in males. For females, marital status was more important.
Reduction of oxidative cellular damage by overexpression of the thioredoxin TRX2 gene improves yield and quality of wine yeast dry active biomass
Authors: Gómez-Pastor Rocío , Pérez-Torrado Roberto , Cabiscol Elisa , Ros Joaquim , Matallana Emilia 
Published: February 2010

Abstract

Background
Wine Saccharomyces cerevisiae strains, adapted to anaerobic must fermentations, suffer oxidative stress when they are grown under aerobic conditions for biomass propagation in the industrial process of active dry yeast production. Oxidative metabolism of sugars favors high biomass yields but also causes increased oxidation damage of cell components. The overexpression of the TRX2 gene, coding for a thioredoxin, enhances oxidative stress resistance in a wine yeast strain model. The thioredoxin and also the glutathione/glutaredoxin system constitute the most important defense against oxidation. Trx2p is also involved in the regulation of Yap1p-driven transcriptional response against some reactive oxygen species.

Results
Laboratory scale simulations of the industrial active dry biomass production process demonstrate that TRX2 overexpression increases the wine yeast final biomass yield and also its fermentative capacity both after the batch and fed-batch phases. Microvinifications carried out with the modified strain show a fast start phenotype derived from its enhanced fermentative capacity and also increased content of beneficial aroma compounds. The modified strain displays an increased transcriptional response of Yap1p regulated genes and other oxidative stress related genes. Activities of antioxidant enzymes like Sod1p, Sod2p and catalase are also enhanced. Consequently, diminished oxidation of lipids and proteins is observed in the modified strain, which can explain the improved performance of the thioredoxin overexpressing strain.

Conclusions
We report several beneficial effects of overexpressing the thioredoxin gene TRX2 in a wine yeast strain. We show that this strain presents an enhanced redox defense. Increased yield of biomass production process in TRX2 overexpressing strain can be of special interest for several industrial applications.
Development and comparison of a minimally-invasive model of autologous clot pulmonary embolism in Sprague-Dawley and Copenhagen rats
Authors: Runyon Michael S , Gellar Michael A , Sanapareddy Nina , Kline Jeffrey A , Watts John A 
Published: February 2010

Abstract

Background
Experimental models of pulmonary embolism (PE) that produce pulmonary hypertension (PH) employ many different methods of inducing acute pulmonary occlusion. Many of these models induce PE with intravenous injection of exogenous impervious objects that may not completely reproduce the physiological properties of autologous thromboembolism. Current literature lacks a simple, well-described rat model of autlogous PE. Objective: Test if moderate-severity autologous PE in Sprague-Dawley (SD) and Copenhagen (Cop) rats can produce persistent PH.

Methods
blood was withdrawn from the jugular vein, treated with thrombin-Ca++ and re-injected following pretreatment with tranexamic acid. Hemodynamic values, clot weights and biochemical measurements were performed at 1 and 5 days.

Results
Infusion of clot significantly increased the right ventricular peak systolic pressure to 45-55 mm Hg, followed by normalization within 24 hours in SD rats, and within 5 days in COP rats. Clot lysis was 95% (24 hours) and 97% (5 days) in SD rats and was significantly lower in COP rats (70%, 24 hours; 87% 5 days). Plasma D-dimer was elevated in surgical sham animals and was further increased 8 hours after pulmonary embolism. Neither strain showed a significant increase in bronchoalveolar chemotactic activity, myeloperoxidase activity, leukocyte infiltration, or chemokine accumulation, indicating that there was no significant pulmonary inflammation.

Conclusions
Both SD and COP rats exhibited near complete fibrinolysis of autologous clot PE within 5 days. Neither strain developed persistent PH. Experimental models of PE designed to induce sustained PH and a robust inflammatory response appear to require significant, persistent pulmonary vascular occlusion.
Expression Genetics Identifies Spinal Mechanisms Supporting Formalin Late Phase Behaviors
Authors: Li Xiangqi , Sahbaie Peyman , Zheng Ming , Ritchie Jennifer , Peltz Gary , Mogil Jeffrey S , Clark J David 
Published: February 2010

Background: Formalin injection into rodent hind paws is one of the most commonly employed pain assays. The resulting nocifensive behaviors can be divided into two phases differing in timing, duration and underlying mechanisms. Spinal sensitization has long been felt to participate in the second phase of this response, although this sensitization is incompletely understood. By using correlative analysis between spinal gene expression and mouse strain-dependent intensity of late phase behavior, we hypothesized genes participating in variability of the response could be identified. Results: Late phase formalin behavior scores among 10 inbred mouse strains were correlated with a spinal cord gene expression database constructed using expression arrays. Messenger RNA levels for several genes were highly correlated with the late phase behavioral responses. Most of these genes had already been implicated in mechanisms regulating pain and analgesia. One of the most strongly correlated genes, Mapk8 coding for c-Jun N-terminal kinase 1 (JNK1), was chosen for further analysis. Studies using additional strains of mice confirmed that spinal cord mRNA expression levels of Mapk8 followed the pattern predicted by strain-specific levels of formalin behavior. Interestingly, spinal cord JNK1 protein levels displayed an inverse relationship with mRNA measurements. Finally, intrathecal injections of the selective JNK inhibitor, SP600125, selectively reduced late phase licking behavior. Conclusions: Wide differences in pain behaviors, including those resulting from the injection of formalin, can be observed in inbred strains of mice suggesting strong genetic influences. Correlating levels of gene expression in tissues established to be mechanistically implicated in the expression of specific behaviors can identify genes involved in the behaviors of interest. Comparing formalin late phase behavior levels with spinal cord gene expression yielded several plausible gene candidates, including the Mapk8 gene. Additional molecular and pharmacologic evidence confirmed a functional role for this gene in supporting formalin late phase responses.
Midgut pain due to an intussuscepting terminal ileal lipoma: a case report
Authors: Abbasakoor Noormuhammad O , Kavanagh Dara O , Moran Diarmaid C , Ryan Barbara , Neary Paul C 
Published: February 2010

Abstract

Introduction
The occurrence of intussusception in adults is rare. The condition is found in 1 in 1300 abdominal operations and 1 in 100 patients operated for intestinal obstruction. The child to adult ratio is 20:1.

Case presentation
A 52-year-old Irish Caucasian woman was investigated for a 3-month history of intermittent episodes of colicky midgut pain and associated constipation. Ileocolonoscopy revealed a pedunculated lesion in the terminal ileum prolapsing into the caecum. Computed tomography confirmed a smooth-walled, nonobstructing, low density intramural lesion in the terminal ileum with secondary intussusception. A laparoscopic small bowel resection was performed. Histology revealed a large pedunculated polypoidal mass measuring 4 × 2.5 × 2 cm consistent with a submucosal lipoma. She had complete resolution of her symptoms and remained well at 12-month follow-up.

Conclusion
This case highlights an unusual cause of incomplete small bowel obstruction successfully treated through interdisciplinary cooperation. Ileal lipomas are not typically amenable to endoscopic removal and require resection. This can be successfully achieved via a laparoscopic approach with early restoration of premorbid functioning.