bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduced erythrocyte deformability in active and untreated Behçet’s disease patients
Authors: Tatlican Semih , Duran Fatma Simsek , Eren Cemile , Eskioglu Fatma , Dikmenoglu Neslihan , Oktay Bilgen , Durmazlar Selda Pelin Kartal , Canpolat Filiz 
Published: January 2010

AbstractObjective  Although the etiology of Behcet’s disease is not clarified yet, the vascular endothelial damage and thrombosis are prominent features of the disease. The underlying mechanisms of increased risk of thrombosis in Behcet’s disease are not completely understood. It is stated that the changes in blood rheology such as erythrocyte deformability take part in the thrombosis. There are limited numbers of studies with conflicting results about the erythrocyte deformability in Behcet’s disease. The previous studies were not limited to the untreated patients with active disease.Method  Blood samples were filtered immediately by “Imugard‐ leukocyte removal filter”. After plasma and erythrocytes were separated by centrifugation, 10% erythrocyte suspensions were prepared with isotonic Tris NaCl buffer solution. These erythrocyte suspensions were filtered under gravitational force by “Nucleopore” to determine the filtration time. The filtration times of the erythrocyte and buffer solutions were referred as t1 and t2 respectively. Finally, deformability indices were obtained by dividing the t1 by t2. A decrease in the deformability of the erythrocytes would result in an increase in the filtration time of the erythrocyte suspension and deformability indices.Results  The median deformability indices were 3.090 and 2.170 for patients and control subjects respectively and the difference was statistically significant (P = 0.000).Conclusion  We suggest that the decrease in erythrocyte deformability in Behcet’s disease may be related to oxidative damage of erythrocytes and subsequently takes part in the development of thrombosis in Behcet’s disease.
A randomized and controlled trial about the use of oral isotretinoin for photoaging
Authors: Bagatin Ediléia , Parada Meire O B , Miot Hélio A , Hassun Karime M , Michalany Nilceo , Talarico Sergio 
Published: January 2010

AbstractTopical retinoids are used to treat photoaging; oral isotretinoin is gold standard for acne; “off label” indications, including photoaging, have been reported with insufficient evidence of efficacy. This is a randomized controlled phase II trial with clinical and histological assessment to evaluate efficacy and safety of oral isotretinoin for photoaging. Study population was comprised of 32 menopausal or sterilized women, aged 40–55, divided in 2 groups: A (21) received 20mg isotretinoin, 3 times per week, nightly moisturizer, and daily sunscreen, for three months; B (11) just moisturizer/sunscreen. Main outcome measures were: overall clinical assessment; profilometry, corneometer and elasticity tests in periocular regions and left forearm; before/after biopsies from left forearm in patients of B and in 10 randomly selected of A. Microscopic blinded evaluation of epidermal thickness, dermal elastosis, new collagen, p53 epidermal expression was performed by quantitative digital image analysis. All data were submitted to statistical analysis. Clinical evaluation showed slight improvement; profilometry, corneometer and skin elasticity tests presented significant difference in pre/post values (P = 0.001 to 0.028), but no differences between A/B. Histological findings and p53 expression were comparable between groups before treatment (P > 0.1); microscopic analysis showed no differences between groups for most variables, after treatment. Slight but significant difference between A/B for p53 with major reduction post isotretinoin [0.66±0.31 vs. 0.94±0.34 respectively (P = 0.04) was observed. There were minor side effects and no significant laboratory test alterations. We concluded that no significant clinical, microscopic changes but p53 epidermal expression reduction were observed. The role of ultra‐violet induced p53 mutation in skin carcinogenesis reinforces retinoids chemoprevention. Oral isotretinoin seemed safe but not effective to treat photoaging. Caution should be considered for women prone to pregnancy. Further controlled studies are necessary.
Reduction of asthma burden is possible through National Asthma Plans
Authors: Kupczyk M. , Haahtela T. , Cruz A. A. , Kuna P. 
Published: January 2010

To cite this article: Kupczyk M, Haahtela T, Cruz AA, Kuna P. Reduction of asthma burden is possible through National Asthma. Allergy 2010; 65: 415–419.AbstractDespite increase in understanding of asthma patomechanisms the practical actions to lessen asthma burden in the communities are far behind of scientific knowledge. There are still reports of uderdiagnosis and poor treatment leading to repeated severe exacerbations, often demanding emergency care and hospitalisation, which cause most of the economic burden both for families and society. From the public health perspective, the key issue is to implement the best standards of care in every‐day practice. The problems are different in high income compared to low‐ and middle‐income countries, and the solutions have to be tailored to each country needs and resources. We present here examples from Finland, Poland and Brazil, to show that asthma burden can be reduced using varied strategies in quite different societal, economical and health care environments. The experience from those interventions confirms that regardless of the health care system and its coverage, a major change for the better can be achieved by local efforts, systematic planning and networking to implement the best asthma practice.
Consumption of vegetables, fruit, and antioxidants during pregnancy and wheeze and eczema in infants
Authors: Miyake Y. , Sasaki S. , Tanaka K. , Hirota Y. 
Published: January 2010

To cite this article: Miyake Y, Sasaki S, Tanaka K, Hirota Y. Consumption of vegetables, fruit, and antioxidants during pregnancy and wheeze and eczema in infants. Allergy 2010; 65: 758–765.AbstractBackground:  Two previous cohort studies showed inverse relationships between maternal vitamin E and zinc intake during pregnancy and the risk of wheeze and/or asthma in the offspring. We investigated the association between maternal intake of vegetables, fruit, and selected antioxidants during pregnancy and the risk of wheeze and eczema in the offspring aged 16–24 months.Methods:  Subjects were 763 Japanese mother–child pairs. Data on maternal intake during pregnancy were assessed with a diet history questionnaire. Data on symptoms of wheeze and eczema were based on criteria of the International Study of Asthma and Allergies in Childhood.Results:  Higher maternal intake of green and yellow vegetables, citrus fruit, and β‐carotene during pregnancy was significantly associated with a reduced risk of eczema, but not wheeze, in the offspring {adjusted odds ratios (ORs) between extreme quartiles [95% confidence intervals (CIs)] = 0.41 (0.24–0.71), 0.53 (0.30–0.93), and 0.52 (0.30–0.89), respectively}. Maternal vitamin E consumption during pregnancy was significantly inversely related to the risk of infantile wheeze, but not eczema [adjusted OR (95% CI) = 0.54 (0.32–0.90)]. No statistically significant exposure–response associations were observed between maternal intake of total vegetables, vegetables other than green and yellow vegetables, total fruit, apples, α‐carotene, vitamin C, or zinc and the risk of wheeze or eczema in the children.Conclusions:  Higher maternal consumption of green and yellow vegetables, citrus fruit, and β‐carotene during pregnancy may be protective against the development of eczema in the offspring. Higher maternal vitamin E intake during pregnancy may reduce the risk of infantile wheeze.
Influence of Cysteamine on In Vitro Maturation, In Vitro and In Vivo Fertilization of Equine Oocytes
Authors: Deleuze S , Dubois CS , Caillaud M , Bruneau B , Goudet G , Duchamp G 
Published: January 2010

ContentsThe effect of cysteamine on in vitro nuclear and cytoplasmic maturation of equine oocytes collected by transvaginal ultrasound guided follicular aspiration was assessed. Oocytes were matured in vitro with (cysteamine group) or without (control group) cysteamine. The nuclear stage after DNA Hoechst staining, penetration rates after two different in vitro fertilization (IVF) techniques (IVF media with ionophore and Hepes buffer with heparin) and the embryo yield following oocyte intra‐oviductal transfer were used as a criterion for assessing nuclear and cytoplasmic maturation, respectively. Contrary to the data described in other domestic species, there was no effect of cysteamine on in vitro nuclear maturation, IVF or in vivo embryonic development under our conditions. Ovum pick up yields (52%) and maturation rates (control group: 47% and cysteamine group: 55%) were similar to those previously reported. From 57 oocytes transferred to the oviduct in each group, the number of embryos collected was 10 (17%) in the control group and five in the cysteamine group (9%). Those two percentages were not statistically different (p > 0.05). No effect of IVF technique was seen on the success rate (6%) in each group.
The Effect of a Chronic Stressor, Lameness, on Detailed Sexual Behaviour and Hormonal Profiles in Milk and Plasma of Dairy Cattle
Authors: Walker SL , Smith RF , Jones DN , Routly JE , Morris MJ , Dobson H 
Published: January 2010

ContentThe objectives of the present study were to quantify the effects of a biological chronic stressor (lameness) on the duration and frequency of different oestrous behaviours in parallel with milk hormone profiles. Dairy cows 51.8 ± 1.4 days postpartum (n = 59), including 18 non‐lame control cows, were scored for lameness and closely observed for signs of oestrus having had their follicular phases synchronized by administration of gonadotrophin‐releasing‐hormone (GnRH) followed by prostaglandin F2α (PG) 7 days later. Lameness shortened the period when herd‐mates attempted to mount the lame cows (1.83 ± 0.69 h vs 5.20 ± 1.53 h; p = 0.042) but did not affect the overall duration of total behaviours (lame 12.3 ± 1.3 h vs non‐lame 15.2 ± 1.3 h). Lameness also lowered the intensity of oestrus [1417 ± 206 points (n = 18) vs 2260 ± 307 points (n = 15); p = 0.029]. Throughout the synchronized oestrous period, lame cows mounted the rear of herd‐mates less frequently (p = 0.020) and tended to chin rest less (p = 0.075). Around the period of maximum oestrous intensity, lameness also diminished the proportion of cows mounting the rear of another cow and chin resting (p = 0.048, p = 0.037, respectively). Furthermore, lame cows had lower progesterone values during the 6 days before oestrous (p ≤ 0.05). Fewer lame cows were observed in oestrus following PG (non‐lame 83%, lame 53%; p = 0.030); however, if prior progesterone concentrations were elevated, lame cows were just as likely to be observed in oestrus. In conclusion, following endogenous progesterone exposure, lameness shortens the period when herd‐mates attempt to mount lame cows but does not affect the incidence of oestrous. However, lame cows are mounted less frequently and express oestrus of lower intensity. This is associated with lower progesterone prior to oestrus but not with abnormal oestradiol or cortisol profiles in daily milk samples.
Clinical and pharmacologic risk factors for neuroleptic malignant syndrome and their association with death
Authors: Tural Ümit , Önder Emin 
Published: January 2010

Aim:  The aim of the present study was to evaluate demographics, clinical features, psychiatric diagnoses and prognosis of neuroleptic malignant syndrome (NMS) reported in Turkey, and to assess their association with mortality.Methods:  Data on all reported cases of NMS in the Turkish Psychiatric Index between 1985 and 2005 were collected. The type, dosage and administration period of neuroleptics, the clinical and laboratory findings; and prognosis were compared in terms of mortality.Results:  Thirty‐six patients with a mean age of 33.67 ± 16.98 years were identified. Fifteen (41.7%) were diagnosed as having schizophrenia or other psychotic disorders and the same number were diagnosed as having affective disorder. Remaining five (13.9%) were diagnosed with other psychiatric disorders and 1 (2.7%) had no psychiatric diagnosis. Twenty‐two (61.1%) of the NMS cases were associated with high potency typical neuroleptics. Association between an atypical antipsychotic and NMS has been reported in one case. NMS appeared within 7 days after initiation of the antipsychotic medication in the majority of samples (n = 19, 52.8%). Several combinations of rescue treatments were used in the majority of cases (n = 19, 52.8%), although bromocriptine (n = 22, 61.1%) was the most frequently preferred rescue treatment for NMS. Benzodiazepines were significantly better than the other treatment options in preventing mortality. Five out of the 36 patients (13.9%) with NMS had died. Age was the only significant independent factor that was associated with mortality.Conclusions:  Benzodiazepines may be included in the treatment of NMS. The mortality rate due to NMS in Turkey was lower than the previously reported rates from other developing countries.
A Simple Two‐Sector Model of Outsourcing
Authors: Batra Ravi , Beladi Hamid 
Published: January 2010

AbstractOutsourcing has become an increasingly contentious subject ever since N. Gregory Mankiw remarked in 2004 that outsourcing is just another way of doing international trade, and must be beneficial to the nation, including the workers. We construct a simple two‐sector specific‐factor model and explore the validity of Mankiw's remarks. We find his ideas are valid when the country does not produce any outsourced factor's work at home in that both the laborers and the nation benefit. But when some outsourced factorcumintermediate good is also produced at home, the nation still benefits but the workers may suffer.
Technology Gap Matters on Spillover
Authors: Sawada Naotaka 
Published: January 2010

AbstractThis paper develops an oligopoly model with endogenous technology spillovers through foreign direct investment (FDI). The foreign entrant brings a superior technology and therefore may spend resources to prevent spillovers of its technology to the home firm. The home firm has an incentive to spend resources to gain these spillovers. After firms strategically choose their expenditures to influence technology spillovers, they compete in a Cournot–Nash quantity game. This study provides theoretical insight on the positive and negative empirical spillover results of FDI on productivity of local firms. Up to a critical bound, the larger the initial technology gap between the foreign and home firms, the more the home firm spends to gain spillovers. Past that boundary, the home firm decreases spending. As a result, the home firm's profits from spillovers vary, but larger technology gaps engender greater net profit losses from FDI.
Arteriolosclerotic ulcer of Martorell
Authors: Vuerstaek JDD , Reeder SWI , Henquet CJM , Neumann HAM 
Published: January 2010

AbstractIn 1945, Martorell described ischaemic leg ulcers in patients with hypertension. He suggested that the ischaemic necrosis was secondary to a hypertensive arteriolar disease and referred to them as ‘hypertensive ischaemic ulcers’. In recent years, the specific entity of these ulcers has been questioned. Others claim they have a much higher incidence, but presume the diagnosis is frequently missed. Almost 900 cases of Martorell’s ulcers have been reported in literature since the first description. A systematic review and comprehensive search of literature (evidence‐based) was needed to characterize this type of ulcer. Based on aetiology and histopathology, it seems to be justified to maintain the name ‘arteriolosclerotic ulcer of Martorell’. We conclude that the arteriolosclerotic ulcer of Martorell is a specific entity with its own clinical and histological diagnostic keys, wound management and preventive measures. We introduce a set of criteria that may be used to facilitate diagnosing arteriolosclerotic ulcer of Martorell as well as a flowchart that includes diagnosis, treatment and prevention of this particular type of vascular leg ulcer.
The interplay of permeability and fluid properties as a first order control of heat transport, venting temperatures and venting salinities at mid‐ocean ridge hydrothermal systems
Authors: DRIESNER T. 
Published: January 2010

Geofluids (2010) 10, 132–141AbstractWhile the fundamental influence of fluid properties on venting temperatures in mid‐ocean ridge (MOR) hydrothermal systems is now well established, the potential interplay of fluid properties with permeability in controlling heat transfer, venting temperatures, and venting salinities has so far received little attention. A series of numerical simulations of fully transient fluid flow in a generic, across‐axis model of a MOR with a heat input equivalent to magmatic supply at a spreading rate of 10 cm year−1 shows a strong dependence of venting temperature and salinity on the system’s permeability. At high permeability, venting temperatures are low because fluid fluxes are so high that the basal conductive heating cannot warm the large fluid masses rapidly enough. The highest venting temperature around 400°C as well as sub‐seafloor fluid phase separation occur when the permeability is just high enough that the fluid flux can still accommodate all heat input for advection, or for lower permeabilities where advection is no longer capable to transfer all incoming magmatic heat. In the latter case, additional mechanisms such as eruptions of basaltic magma may become relevant in balancing heat flow in MOR settings. The results can quantitatively be explained by the ‘fluxibility’ hypothesis of Jupp & Schultz (Nature, 403, 2000, 880), which is used to derive diagrams for the relations between basal heat input, permeability and venting temperatures. Its predictive capabilities are tested against additional simulations. Potential implications of this work are that permeability in high‐temperature MOR hydrothermal systems may be lower than previously thought and that low‐temperature systems at high permeability may be an efficient way of removing heat at MOR.
Edge effects and the impact of non‐protected areas in carnivore conservation: leopards in the Phinda–Mkhuze Complex, South Africa
Authors: Balme G. A. , Slotow R. , Hunter L. T. B. 
Published: January 2010

AbstractAlthough high rates of anthropogenic mortality are often reported for carnivores near reserve borders, the resulting edge effects are rarely quantified, and the consequences on conservation goals are usually unknown. Here, we assess the extent and impact of edge effects on a protected leopard Panthera pardus population in the Phinda‐Mkhuze Complex (PMC), South Africa. We compared the spatial and demographic characteristics of leopards in two areas of the PMC, one closer to the border than the other. Leopard density declined from the core of the reserve (11.11 ± 1.31 leopards 100 km−2) to the border (7.17 ± 1.12  leopards 100 km−2), and was the lowest in non‐protected areas adjoining the PMC (2.49 ± 0.87 leopards 100 km−2), but was not related to prey abundance or interspecific competition. Radiotelemetry showed that leopards near the border spent a greater proportion of their time outside the reserve and suffered higher annual mortality rates (0.358 ± 0.075) than those closer to the core (0.122 ± 0.065). A Cox proportional hazards model further demonstrated the negative effect of time spent outside the reserve on the survival probability of leopards. Despite an increased risk of mortality, leopards did not avoid non‐protected areas, which may have functioned as an ecological trap for predators. Although the overall conservation outcome of the reserve was positive, edge effects clearly weakened the potential of the PMC to protect leopards. Our findings show that high mortality rates of carnivores in areas bordering reserves can extend to protected populations. Management approaches that control human activities on both sides of administrative borders are therefore essential if reserves are to conserve large carnivores effectively.
Evaluation of a classroom‐based psychosocial intervention in conflict‐affected Nepal: a cluster randomized controlled trial
Authors: Jordans Mark J.D. , Komproe Ivan H. , Tol Wietse A. , Kohrt Brandon A. , Luitel Nagendra P. , Macy Robert D. , De Jong Joop T.V.M. 
Published: January 2010

Background:  In situations of ongoing violence, childhood psychosocial and mental health problems require care. However, resources and evidence for adequate interventions are scarce for children in low‐ and middle‐income countries. This study evaluated a school‐based psychosocial intervention in conflict‐affected, rural Nepal.Methods:  A cluster randomized controlled trial was used to evaluate changes on a range of indicators, including psychiatric symptoms (depression, anxiety, posttraumatic stress disorder), psychological difficulties, resilience indicators (hope, prosocial behavior) and function impairment. Children (n = 325) (mean age = 12.7, SD = 1.04, range 11–14 years) with elevated psychosocial distress were allocated to a treatment or waitlist group.Results:  Comparisons of crude change scores showed significant between‐group differences on several outcome indicators, with moderate effect sizes (Cohen d = .41 to .58). After correcting for nested variance within schools, no evidence for treatment effects was found on any outcome variable. Additional analyses showed gender effects for treatment on prosocial behavior (mean change difference: 2.70; 95% CI, .97 to 4.44), psychological difficulties (−2.19; 95% CI, −3.82 to −.56), and aggression (−4.42; 95% CI, −6.16 to −2.67). An age effect for treatment was found for hope (.90; 95% CI, −1.54 to −.26).Conclusions:  A school‐based psychosocial intervention demonstrated moderate short‐term beneficial effects for improving social‐behavioral and resilience indicators among subgroups of children exposed to armed conflict. The intervention reduced psychological difficulties and aggression among boys, increased prosocial behavior among girls, and increased hope for older children. The intervention did not result in reduction of psychiatric symptoms.