bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Paleozoic accretionary history of the Pearya terrane: New insights from igneous and detrital zircon signatures of the Kulutingwak Formation, Ellesmere Island, Nunavut, Canada
Authors: Koch Megan M. , McClelland William C. , Gilotti Jane A. , Kośmińska Karolina , Strauss Justin V. , Faehnrich Karol , Beranek Luke P. , Pease Victoria 
Published: April 2024

AbstractThe juxtaposition of the composite Pearya terrane and the northern Laurentian margin at Ellesmere Island, Nunavut, Canada, has significant ramifications for the Paleozoic tectonic history of the circum-Arctic region. Published tectonic models rely upon interpretation of the subduction-related Kulutingwak Formation as an indicator of Ordovician and/or Silurian accretion (Trettin, 1998). New igneous and detrital zircon U-Pb and Lu-Hf isotopic data from 16 samples collected in the Yelverton Inlet–Kulutingwak Fiord region of northern Ellesmere Island suggest that the Kulutingwak Formation of Trettin (1998) contains structural blocks derived from both the Pearya terrane and Silurian strata associated with the ancestral Laurentian margin. Data from this study demonstrate a complex provenance history for rocks within the Petersen Bay, Kulutingwak Fiord, and Emma Fiord fault zones, with age probability peaks of ca. 470 Ma, 650 Ma, and 960–980 Ma that suggest affinity with the Pearya terrane, and age probability peaks of ca. 1800 Ma and 2700 Ma that indicate connections to the Laurentian margin. The combination of these signatures in Kulutingwak Formation rocks suggests that the Pearya terrane was proximal to the northern Laurentian margin by Late Ordovician time. Silurian and younger strike-slip displacement on the major fault zones resulted in the incorporation of blocks derived from the Pearya terrane basement and Silurian clastic rocks into the Kulutingwak Formation. Silurian displacement along these strike-slip faults, which are integral components of the Canadian Arctic transform system, is recorded by syndepositional deformation structures in the Danish River Formation and prevented the transition from soft to hard collision of the Pearya terrane. The two-stage model for the Pearya terrane—accretion followed by significant translation—provides a process for developing complex steep terrane boundaries with contentious displacement histories that are common in accretionary orogens.
Fifteen-minute consultation: Approach to a child with congenital insensitivity to pain
Authors: Anuar Muhamad Azamin , Whitehouse Emily Rose , Varma Uma , McCullagh Gary , Hughes Imelda 
Published: April 2024

The hereditary sensory and autonomic neuropathies (HSANs) are a group of rare genetic disorders characterised by variable phenotypic expression affecting both sensory and autonomic dysfunction. Diagnosing these conditions can be a challenge as the presenting symptoms can be diverse and may overlap. This often leads to a delay in referral and diagnosis.Pain is often used by clinicians as a marker for systemic diseases. The key feature of HSAN conditions is the absence of pain perception and its consequences such as unexplained injuries. When a child presents with an unexplained injury, a diagnosis of non-accidental injuries must be considered, but rarely HSAN could be a possibility.The diagnosis of HSANs in children is both important and rare. This article aims to discuss an approach to the diagnosis and management of HSANs.
How therapeutic relationships develop in group-based telehealth and their perceived impact on processes and outcomes of a complex intervention: a qualitative study
Authors: Sousa Filho Luis Fernando , Farlie Melanie K , Haines Terry P , Malliaras Peter 
Published: April 2024

Background
Therapeutic relationships are a key domain in healthcare delivery. While well-understood in in-person interventions, how therapeutic relationships develop in more complex contexts is unclear. This study aimed to understand (1) how therapeutic relationships are developed during the telehealth delivery of a group-based, complex intervention and (2) the perceived impact of these relationships on intervention processes, such as intervention delivery and engagement, and patient outcomes, such as patient safety and satisfaction.

Methods
This qualitative study, nested within a randomised controlled trial, used an interpretivist approach to explore the perceptions of 25 participants (18 patients with shoulder pain and 7 clinicians) regarding developing therapeutic relationships in a group-based, complex intervention delivered via telehealth. Semi-structured interviews were conducted within 4 weeks of the telehealth intervention period and then analysed through in-depth, inductive thematic analysis.

Results
We identified six themes: (1) ‘Patients trust clinicians who demonstrate credibility, promoting the development of therapeutic relationships’; (2) ‘Simple features and approaches shape the therapeutic relationship’, including small talk, time spent together and social observation; (3) ‘A sense of belonging and support fosters connections’, facilitated by clinicians providing individualised attention within the group; (4) ‘Developing therapeutic relationships can impact the delivery of core intervention components’, reflecting challenges clinicians faced; (5) ‘Therapeutic relationships can facilitate intervention engagement’, through enhanced patient understanding and confidence and (6) ‘Therapeutic relationships can contribute to patient safety and satisfaction’, with patients feeling more comfortable reporting intervention-related issues.

Conclusions
Therapeutic relationships were developed during group-based telehealth sessions through a set of factors that may require additional skills and effort compared with in-person interactions. While these relationships have a perceived positive impact on intervention engagement and patient outcomes, clinicians need to find a balance between building relationships and delivering the telehealth intervention with fidelity.

Trial registration number
ACTRN12621001650886.
Incidence, prevalence and mortality of idiopathic pulmonary fibrosis in England from 2008 to 2018: a cohort study
Authors: Gupta Rikisha , Morgan Ann Dorothy , George Peter M , Quint Jennifer K 
Published: April 2024

BackgroundOwing to discrepancies in methodologies and how idiopathic pulmonary fibrosis (IPF) is diagnosed it is challenging to establish a consistent understanding of the disease burden In the UK, over 10 years ago, the incidence and prevalence of IPF were reported as 2.8–8.7 per 100 000 person-years (from 2000 to 2012) and 39 per 100 000 persons (in 2012), respectively. Here, we estimated the incidence and prevalence of IPF in England from 2008 to 2018 and investigated IPF mortality.MethodsUsing Clinical Practice Research Datalink Aurum and Hospital Episode Statistics (HES) linked datasets, we estimated incidence and prevalence using four validated diagnostic-code-based algorithms. Using the registered number of deaths (from Office of National Statistics) with the underlying cause being recorded as IPF, we estimated IPF mortality for the same period.ResultsUsing Aurum-based definitions, incidence increased over time by 100% for Aurum narrow (3–6.1 per 100 000 person-years) and by 25% for Aurum broad (22.4–28.6 per 100 000 person-years). However, using HES-based definitions showed a decrease in incidence over the same period and lay between the two extremes derived for Aurum-based definition. IPF mortality in 2018 was 7.9 per 100 000 person-years and increased by 53% between 2008 and 2018.InterpretationWhen using best-case definitions, incidence rose throughout the study period. Scaling this to England’s population (2018), our best estimate would be in the range of 8000–9000 new cases per year which is higher than previously reported estimates (5000–6000). This increased burden in the new cases of IPF each year impacts future health service planning and resource allocation.
Quantum soft-covering lemma with applications to rate-distortion coding, resolvability and identification via quantum channels
Authors: Atif Touheed Anwar , Pradhan S. Sandeep , Winter Andreas 
Published: April 2024

We propose a quantum soft-covering problem for a given general quantum channel and one of its output states, which consists in finding the minimum rank of an input state needed to approximate the given channel output. We then prove a one-shot quantum covering lemma in terms of smooth min-entropies by leveraging decoupling techniques from quantum Shannon theory. This covering result is shown to be equivalent to a coding theorem for rate distortion under a posterior (reverse) channel distortion criterion by two of the present authors. Both one-shot results directly yield corollaries about the i.i.d. asymptotics, in terms of the coherent information of the channel. The power of our quantum covering lemma is demonstrated by two additional applications: first, we formulate a quantum channel resolvability problem, and provide one-shot as well as asymptotic upper and lower bounds. Second, we provide new upper bounds on the unrestricted and simultaneous identification capacities of quantum channels, in particular separating for the first time the simultaneous identification capacity from the unrestricted one, proving a long-standing conjecture of the last author.
Anadyr Basin Composite Tectono-Sedimentary Element, Chukotka Peninsula, NE Asia
Authors: Ershova V. B. , Antipov M. P. , Agapitov D. D. , Bordovskaya T. O. , Prokopiev A. V. , Shimanskiy S. V. , Akinin V. 
Published: April 2024

The Anadyr Basin reflects the tectonic history of the Chukotka and Kamchatka peninsulas in the late Mesozoic and Cenozoic. It is located at the junction of the Novosibirsk–Chukotka, West Koryak and Koryak–Kamchatka fold and thrust belts (FTBs) along the NE margin of Eurasia. The basin includes a latest Cretaceous–Cenozoic succession that is divided by several unconformities caused by tectonic events within the surrounding thrust belts, resulting in several episodes of basin inversion, uplift and erosion. Accordingly, and in the framework of this memoir, the basin is described as a composite tectono-sedimentary element (CTSE).
Four gas and oil discoveries are known from the onshore part of the basin. The hydrocarbon prospectivity of the area is determined by the presence of latest Cretaceous–Eocene source rocks and Miocene reservoirs.
The purpose of this chapter is to provide an overview of geological and geophysical studies, as well as exploration work for oil and gas undertaken during the late Soviet period and in more recent times in the Anadyr Basin.
Case 324: CHANTER Syndrome
Authors: Suthar Pokhraj Prakashchandra , Hughes Kathryn , Mafraji Mustafa , Akyuz Melih , Jhaveri Miral , Dua Sumeet G. 
Published: April 2024

History A 69-year-old right-handed man with a history of substance use disorder, hypertension, and diabetes presented to the emergency department in an unresponsive state. Upon examination, apart from tachycardia (heart rate, 108 beats per minute), vital signs were within normal ranges (blood pressure, 134/102 mm Hg; temperature, 97.9 ºF (36.6 ºC); respiratory rate, 16 per minute; oxygen saturation, 96%). The patient had a Glasgow coma scale score of 8. Otherwise, the physical examination revealed no abnormalities. Prior psychiatric and surgical histories were unremarkable. There was no history of recent travel, camping, hiking, or vaccination. No family history could be obtained. Laboratory work-up revealed an elevated creatine kinase level (49 006 U/L [818.4 μkat/L]; normal reference range, 10–205 U/L [0.17–3.42 μkat/L]). An electrocardiogram showed sinus tachycardia without evidence of cardiac ischemia. An echocardiogram was unremarkable. Alanine aminotransferase (126 U/L [2.10 μkat/L]; normal reference range, 0–40 U/L [0–0.67 μkat/L]) and aspartate aminotransferase (488 U/L [8.15 μkat/L]; normal reference range, 3–44 U/L [0.05–0.74 μkat/L]) levels were elevated. Polymerase chain reaction results were negative for HIV-1, HIV-2, syphilis treponemal, and COVID-19 antibodies. The remaining routine laboratory work-up findings were within normal limits. Urine drug screening was positive for cocaine, marijuana, fentanyl, and benzodiazepines. Naloxone was administered, but the patient remained unresponsive. Intubation was performed for airway protection. Noncontrast and contrast-enhanced CT of the head and CT angiography were performed in the emergency department to rule out an acute intracranial abnormality. Multisequence MRI of the brain with administration of intravenous contrast material was ordered for further assessment. CT of the abdomen and pelvis was unremarkable (images not shown).
Toripalimab Plus Bevacizumab as First-line Treatment for Advanced Hepatocellular Carcinoma: A Prospective, Multicenter, Single-Arm, Phase II Trial
Authors: Chen Yajin , Du Chengyou , Shen Shunli , Zhang Wu , Shan Yunfeng , Lyu Ang , Wu Jianhui , Shang Changzhen , Luo Xuan , Wei Jinxing , Xiao Heng , Qiu Jianguo , Hua Yunpeng , Wang Shutong , Wang Ting , Dai Shengjie , Zhang Shuhao , Xie Bingying , Wu Yinghao , Hao Chunyi 
Published: April 2024

Abstract

Purpose:
This phase II, multicenter, prospective, single-arm study aimed to evaluate the efficacy and safety of toripalimab plus bevacizumab for treating advanced hepatocellular carcinoma (HCC).

Patients and Methods:
Treatment-naïve patients with advanced HCC received toripalimab 240 mg plus bevacizumab 15 mg/kg every 3 weeks. The primary endpoints included safety and tolerability and objective response rate (ORR) assessed by the investigator per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1.

Results:
Fifty-four patients were enrolled between April 17, 2020, and December 11, 2020. As assessed by the investigator according to RECIST v1.1, the ORR was 31.5% [95% confidence interval (CI), 19.5–45.6] and the lower bound of the 95% CI was above the prespecified boundary of 10%. The independent review committee (IRC) assessed ORR according to the modified RECIST (mRECIST), which was 46.3% (95% CI, 32.6–60.4). The median progression-free survival was 8.5 (95% CI, 5.5–11.0) and 9.8 months (95% CI, 5.6 to not evaluable) as assessed by the investigator according to RECIST v1.1 and IRC according to mRECIST criteria, respectively. The median overall survival (OS) was not reached, and the 12- and 24-month OS rates were 77.3% and 63.5%, respectively. Grade 3 or higher treatment-emergent adverse events (TEAEs) occurred in 27 patients (50.0%). The most common TEAEs were proteinuria (59.3%), hypertension (38.9%), increased aspartate aminotransferase (33.3%), increased amylase (29.6%), decreased platelet count (27.8%), and increased bilirubin levels (27.8%).

Conclusions:
Toripalimab plus bevacizumab showed a favorable efficacy and safety profile, supporting further studies on this combination regimen as a first-line treatment for advanced HCC.
Spatiotemporal ATF3 Expression Determines VSMC Fate in Abdominal Aortic Aneurysm
Authors: Wen Ying , Liu Yingying , Li Qiang , Tan Jinlin , Fu Xing , Liang Yiwen , Tuo Yonghua , Liu Luhao , Zhou Xueqiong , LiuFu Dongkai , Fan Xuejiao , Chen Chaofei , Chen Zheng , Wang Zhouping , Fan Shunyang , Liu Renjing , Pan Lei , Zhang Yuan , Tang Wai Ho 
Published: April 2024

BACKGROUND:
Abdominal aortic aneurysm (AAA) is a catastrophic disease with little effective therapy, likely due to the limited understanding of the mechanisms underlying AAA development and progression. ATF3 (activating transcription factor 3) has been increasingly recognized as a key regulator of cardiovascular diseases. However, the role of ATF3 in AAA development and progression remains elusive.

METHODS:
Genome-wide RNA sequencing analysis was performed on the aorta isolated from saline or Ang II (angiotensin II)–induced AAA mice, and ATF3 was identified as the potential key gene for AAA development. To examine the role of ATF3 in AAA development, vascular smooth muscle cell–specific ATF3 knockdown or overexpressed mice by recombinant adeno-associated virus serotype 9 vectors carrying ATF3, or shRNA-ATF3 with SM22α (smooth muscle protein 22-α) promoter were used in Ang II–induced AAA mice. In human and murine vascular smooth muscle cells, gain or loss of function experiments were performed to investigate the role of ATF3 in vascular smooth muscle cell proliferation and apoptosis.

RESULTS:
In both Ang II–induced AAA mice and patients with AAA, the expression of ATF3 was reduced in aneurysm tissues but increased in aortic lesion tissues. The deficiency of ATF3 in vascular smooth muscle cell promoted AAA formation in Ang II–induced AAA mice. PDGFRB (platelet-derived growth factor receptor β) was identified as the target of ATF3, which mediated vascular smooth muscle cell proliferation in response to TNF-alpha (tumor necrosis factor-α) at the early stage of AAA. ATF3 suppressed the mitochondria-dependent apoptosis at the advanced stage by upregulating its direct target BCL2. Our chromatin immunoprecipitation results also demonstrated that the recruitment of NFκB1 and P300/BAF/H3K27ac complex to the ATF3 promoter induces ATF3 transcription via enhancer activation. NFKB1 inhibitor (andrographolide) inhibits the expression of ATF3 by blocking the recruiters NFKB1 and ATF3-enhancer to the ATF3-promoter region, ultimately leading to AAA development.

CONCLUSIONS:
Our results demonstrate a previously unrecognized role of ATF3 in AAA development and progression, and ATF3 may serve as a novel therapeutic and prognostic marker for AAA.
Atherosclerosis Is a Smooth Muscle Cell–Driven Tumor-Like Disease
Authors: Pan Huize , Ho Sebastian E. , Xue Chenyi , Cui Jian , Johanson Quinian S. , Sachs Nadja , Ross Leila S. , Li Fang , Solomon Robert A. , Connolly E. Sander , Patel Virendra I. , Maegdefessel Lars , Zhang Hanrui , Reilly Muredach P. 
Published: April 2024

BACKGROUND:
Atherosclerosis, a leading cause of cardiovascular disease, involves the pathological activation of various cell types, including immunocytes (eg, macrophages and T cells), smooth muscle cells (SMCs), and endothelial cells. Accumulating evidence suggests that transition of SMCs to other cell types, known as phenotypic switching, plays a central role in atherosclerosis development and complications. However, the characteristics of SMC-derived cells and the underlying mechanisms of SMC transition in disease pathogenesis remain poorly understood. Our objective is to characterize tumor cell–like behaviors of SMC-derived cells in atherosclerosis, with the ultimate goal of developing interventions targeting SMC transition for the prevention and treatment of atherosclerosis.

METHODS:
We used SMC lineage tracing mice and human tissues and applied a range of methods, including molecular, cellular, histological, computational, human genetics, and pharmacological approaches, to investigate the features of SMC-derived cells in atherosclerosis.

RESULTS:

SMC-derived cells in mouse and human atherosclerosis exhibit multiple tumor cell–like characteristics, including genomic instability, evasion of senescence, hyperproliferation, resistance to cell death, invasiveness, and activation of comprehensive cancer-associated gene regulatory networks. Specific expression of the oncogenic mutant

Kras
G12D

in SMCs accelerates phenotypic switching and exacerbates atherosclerosis. Furthermore, we provide proof of concept that niraparib, an anticancer drug targeting DNA damage repair, attenuates atherosclerosis progression and induces regression of lesions in advanced disease in mouse models.

CONCLUSIONS:
Our findings demonstrate that atherosclerosis is an SMC-driven tumor-like disease, advancing our understanding of its pathogenesis and opening prospects for innovative precision molecular strategies aimed at preventing and treating atherosclerotic cardiovascular disease.
Unconstrained quantitative magnetization transfer imaging: Disentangling T1 of the free and semi-solid spin pools
Authors: Assländer Jakob , Mao Andrew , Marchetto Elisa , Beck Erin S. , Rosa Francesco La , Charlson Robert W. , Shepherd Timothy M. , Flassbeck Sebastian 
Published: April 2024

Abstract
Since the inception of magnetization transfer (MT) imaging, it has been widely assumed that Henkelman’s two spin pools have similar longitudinal relaxation times, which motivated many researchers to constrain them to each other. However, several recent publications reported a T1s of the semi-solid spin pool that is much shorter than T1f of the free pool. While these studies tailored experiments for robust proofs-of-concept, we here aim to quantify the disentangled relaxation processes on a voxel-by-voxel basis in a clinical imaging setting, that is, with an effective resolution of 1.24mm isotropic and full brain coverage in 12min. To this end, we optimized a hybrid-state pulse sequence for mapping the parameters of an unconstrained MT model. We scanned four people with relapsing-remitting multiple sclerosis (MS) and four healthy controls with this pulse sequence and estimated T1f≈1.84s and T1s≈0.34s in healthy white matter. Our results confirm the reports that T1s≪T1f and we argue that this finding identifies MT as an inherent driver of longitudinal relaxation in brain tissue. Moreover, we estimated a fractional size of the semi-solid spin pool of m0s≈0.212, which is larger than previously assumed. An analysis of T1f in normal-appearing white matter revealed statistically significant differences between individuals with MS and controls.
Symeon the New Theologian and The Life of St. Nephon of Constantiane (BHG 1371z)
Authors: Ivanov Sergey A. 
Published: April 2024

Abstract
The Life of St. Nephon (BHG 1371z) has been written between 970 and 992 and became extremely popular immediately after its publication. Therefore, it could become accessible to Symeon the New Theologian very soon after his conversion to spiritual life. The peculiar combination of ecstatic confessions of abominable sins and the simultaneous confidence in his divine chosenness, characteristic of the Life of Nephon, influenced Symeon and became the main style of self-representation in his writings.
An Early Renaissance Hebrew Alchemical Treatise in French Translation (ca. 1540)?
Authors: Kahn Didier , Freudenthal Gad 
Published: April 2024

Abstract
A manuscript, bearing the title Petit traicté de alkimie tourné de langue hebraique en langue francoyse, containing a collection of technical and alchemical recipes allegedly translated from Hebrew, was once donated by the Connétable Anne of Montmorency to his master, the French King François I. Our purpose is to examine whether or not the text indeed goes back to a Hebrew original. We first summarize the manuscript’s history, then examine the modern attribution of the text to Paul Paradis (or Paolo Canossa, 1511–1549), a well-known Hebraist appointed Royal Lecturer in 1530 by King François I. We finally turn to the contents of the Petit traicté de alkimie, and offer our conclusions as to its alleged Hebrew original. In an Appendix we offer a transcription of the entire text of the Petit traicté de alkimie.