bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional dependence as a contributing factor for patient hand contamination by multi-drug resistant organisms (MDROs) in acute care
Authors: Behunin Trenton , Vijayasiri Ganga , Gibson Kristen E. , Mody Lona , Cassone Marco 
Published: May 2024

AbstractObjective:Patient hands’ contribution to disease transmission in healthcare settings is an important, understudied topic. We assessed correlation between patient functional dependence and hand contamination with multi-drug resistant organisms (MDROs) in acute-care settings.Design, setting, and patients:Secondary, cross-sectional analyses of 399 general medicine patients enrolled in two tertiary-care hospitals over a six-month period. Our predictor was patient functional status evaluated using Katz Activities of Daily Living scale, scored as follows: functionally independent (scored 0), moderately dependent (score 1–3), and severely dependent (score of 4 or more). Our outcome was patient hand contamination with MDROs, including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus, and resistant gram-negative bacteria.Results:Of 399 patients, 298 were functionally independent, 45 were moderately dependent, and 56 were severely dependent. Odds of MDRO hand contamination were 2.63 (95% CI, 1.21–5.72) times higher in the severely dependent category compared to the independent category. Patients with feeding dependence had the highest odds of hand contamination with MDROs (OR 4.76, 95% CI, 1.54–14.71), followed by continence, dressing, and toileting. In addition to patient colonization, environmental contamination with MRSA was associated with patient function, with odds 2.60 (95% CI, 1.16–5.82) times higher in severely dependent patients.Conclusions:Patients with severe functional dependence are more likely to harbor MDROs on their hands and less likely to be able to cleanse them independently. Functionally dependent patients have high room contamination with MDROs. Patient hand hygiene interventions in the hospital should target this high-risk group.
A new morphotype description of Arbacia spatuligera Valenciennes, 1846 (Arbacioida, Echinoidea) and bathymetric range extension from mesophotic reefs of the central coast of Chile
Authors: Moreno-Mendoza Rigoberto , Courville Erwan , Angeles-Gonzalez Luis Enrique , Duarte Julio , Carulla Marc , Malfanti-Bravo Daniel , Mena-Auladell Andrés , Saucède Thomas , Simões Nuno , Poulin Elie 
Published: May 2024

Abstract
The sea urchin Arbacia spatuligera is an echinoid distributed in the Southeastern Pacific Ocean from Peru to Chile. This species was previously reported from the subtidal zone with a bathymetric distribution up to 30 m depth. In this work, 128 individuals were found in four mesophotic reefs along the central coast off Chile using closed-circuit rebreathers in technical diving at higher depths than previously, ranging from 36 to 63 m in depth. A population exhibits unexpected morphological characters, requiring an emended diagnosis and description of a new morphotype for A. spatuligera. These morphological traits are further discussed as potential ecophenotypic adaptations.
Beyond the Politics of Fear: Machiavelli on Hope
Authors: Mitchell Colleen E. 
Published: May 2024

AbstractMany Machiavelli scholars emphasize his discussion of fear and neglect the important role that hope plays in his thought. I analyze Machiavelli's frequent references to hope throughout his corpus to offer an explanation of what he means by ‘hope,” examine the relation between hope and fear, and identify the benefits, dangers, and limits of these two foundational and complementary passions. Greater attention to the role of hope in Machiavelli's thought can help us understand the significance of this passion for Machiavelli's political project, particularly his view of freedom.
Female bodies and dynastic legitimacy in the Nereid Monument at Xanthos
Authors: Kim Patricia Eunji 
Published: May 2024

AbstractThis article reassesses the so-called Nereid Monument (ca 380 BCE) at Xanthos in Lycia by focusing on the narrative and symbolic role of female figures within its sculptural programme. Constructed as the tomb for the Lycian dynast Erbbina, the monument has been noted for its over-human-size sculpture of Nereids, its historicising city-siege reliefs, as well as its spectacular fusion of visual and architectural styles, motifs and themes from various contexts throughout the Aegean and Anatolia. Building on this scholarship, I turn specifically to the monument’s innovative representations of non-mythological women in prominent areas of its visual programme: Erbbina’s dynastic consort and a distressed woman who is caught in the throes of military violence. By focusing on the role of female bodies in Erbbina’s funerary qua triumphal monument, I argue for the important narrative function of female bodies in articulating dynastic legitimacy and continuity. Finally, this article comments on the importance of femininity in addition to masculinity in dynastic expressions in the fourth century, thus anticipating major art-historical changes in the art of power at the beginning of the Hellenistic period.
Lifecycle HTA: promising applications and a framework for implementation. An HTAi Global Policy Forum Task Force report
Authors: Pichler Franz B. , Boysen Meindert , Mittmann Nicole , Gilardino Ramiro , Bruce Andrew , Bond Kenneth , Vreman Rick A. , Largeron Nathalie , Banhazi Judit , Ollendorf Daniel A. , Jain Mohit , Upadhyaya Sheela , Goettsch Wim G. 
Published: May 2024

Abstract
The 2022 Health Technology Assessment International (HTAi) Global Policy Forum (GPF) established the goal of developing a position statement and framework for lifecycle HTA (LC-HTA), through a Task Force leveraging multi-stakeholder monthly discussions and GPF member input. The Task Force developed a working definition: LC-HTA is a systematic process utilizing sequential HTA activities to inform decision making where the evidence base, the health technology itself, or the context in which it is applied, has a potential to meaningfully change at different points in its LC. Four key scenarios were identified where it was considered that an LC-HTA approach would add sufficient value to HTA bodies and their key stakeholders to justify the additional resource burden. Based on the four scenarios, a high-level LC-HTA framework was developed consisting of (i) defining the decision problem, (ii) sequencing of HTA activities, and (iii) developing optimization criteria. Subsequently, the Task Force developed operationalization guidance for LC-HTA in a companion paper.
Chemically induced cone degeneration in the 13-lined ground squirrel
Authors: Follett Hannah M. , Warr Emma , Grieshop Jenna , Yu Ching Tzu , Gaffney Mina , Bowie Owen R. , Lee Jong Won , Tarima Sergey , Merriman Dana K. , Carroll Joseph 
Published: May 2024

Abstract
Animal models of retinal degeneration are critical for understanding disease and testing potential therapies. Inducing degeneration commonly involves the administration of chemicals that kill photoreceptors by disrupting metabolic pathways, signaling pathways, or protein synthesis. While chemically induced degeneration has been demonstrated in a variety of animals (mice, rats, rabbits, felines, 13-lined ground squirrels (13-LGS), pigs, chicks), few studies have used noninvasive high-resolution retinal imaging to monitor the in vivo cellular effects. Here, we used longitudinal scanning light ophthalmoscopy (SLO), optical coherence tomography, and adaptive optics SLO imaging in the euthermic, cone-dominant 13-LGS (46 animals, 52 eyes) to examine retinal structure following intravitreal injections of chemicals, which were previously shown to induce photoreceptor degeneration, throughout the active season of 2019 and 2020. We found that iodoacetic acid induced severe pan-retinal damage in all but one eye, which received the lowest concentration. While sodium nitroprusside successfully induced degeneration of the outer retinal layers, the results were variable, and damage was also observed in 50% of contralateral control eyes. Adenosine triphosphate and tunicamycin induced outer retinal specific damage with varying results, while eyes injected with thapsigargin did not show signs of degeneration. Given the variability of damage we observed, follow-up studies examining the possible physiological origins of this variability are critical. These additional studies should further advance the utility of chemically induced photoreceptor degeneration models in the cone-dominant 13-LGS.
The typical and atypical developing mind: a common model
Authors: Demetriou Andreas , Spanoudis George , Papadopoulos Timothy C. 
Published: May 2024

Abstract
We present a theory of atypical development based on a developmental theory of the typical mind integrating developmental, cognitive, and psychometric theory and research. The paper comprises three parts. First, it outlines the theory of typical development. The theory postulates central cognitive mechanisms, such as relational integration, executive and inferential processes, and domain-specific processes underlying different environmental relations, such as visuospatial or quantitative relations. Cognitive development advances in cycles satisfying developmental priorities in mastering these systems, such as executive control from 2–6 years, inferential control from 7–11 years, and truth control from 12–18 years. Second, we discuss atypical development, showing how each neurodevelopmental disorder emerges from deficiencies in one or more of the processes comprising the architecture of the mind. Deficiencies in relational integration mechanisms, together with deficiencies in social understanding, yield autism spectrum disorder. Deficiencies in executive processes yield attention-deficit and hyperactivity disorder. Deficiencies in symbolic representation yield specialized learning difficulties, such as dyslexia and dyscalculia. Finally, we discuss clinical and educational implications, suggesting the importance of early diagnosis of malfunctioning in each of these dimensions and specific programs for their remediation.
Regulating surrogacy intermediaries: a comparative analysis of regulatory approaches and implications in the Chinese context
Authors: Luo Yingyi 
Published: May 2024

AbstractThis article addresses the significant research gap concerning the regulation of surrogacy intermediaries in China’s rapidly growing surrogacy market. Employing a ‘law in context’ perspective, it explores the question of how to effectively regulate surrogacy intermediaries in the Chinese context. Situated within China’s unique socio-cultural landscape, where procreation carries profound significance, the study navigates the complexities of surrogacy regulation, including ethical dilemmas, rights infringements and regulatory ambiguities. The article advocates for the regulation of surrogacy in China to prevent possible exploitation, referencing three international models: prohibiting commercial surrogacy, governing non-profit surrogacy organisations and imposing duties on for-profit surrogacy agents. The aim is to construct a robust, context-sensitive regulatory framework for surrogacy in China, focusing on identifying suitable intermediaries and defining the scope of effective regulatory oversight.
Onset of Plate Motion in the Presence of Chemical Heterogeneities in the Mantle and the Effect of Mantle Temperature
Authors: Stein Claudia , Hansen Ulrich 
Published: May 2024

AbstractChemical heterogeneities of various origins have been observed in the Earth's mantle. Their assumed higher density acts on the style of mantle convection and therefore, as tectonic plates form the highly viscous upper boundary layer of mantle convection, the onset of surface motion is also affected by chemical heterogeneities. We perform 2D basally heated thermochemical mantle convection models which initially include layers of dense material at different mantle depths. In comparison to purely thermal convection models, the onset of first plate motion is delayed. This delay is even more pronounced, the deeper the location of dense material, the larger its volume and the higher its density. Additionally, we varied the starting temperature of our models. In an initially hot mantle, a strong temperature‐dependent viscosity contrast between the mantle and cold surface leads to a cold, highly viscous plate (stagnant lid). For an initially cold mantle, rising plumes first need to transport basal heat upwards to create a sufficient viscosity contrast. Consequently, the formation and subsequent breaking of the stagnant lid is delayed. Considering a hotter mantle after Earth's magma ocean phase, we find that plate motion can occur within approximately the first 0.5 Gyr of solid‐state convection if no chemical structures are present or for dense material situated at the surface. Deep chemical heterogeneities delay the onset by at least one order of magnitude. Furthermore, the early surface motion will have been more erratic than todays stable plate motion, probably with a few single subduction events.
On the Relative Importance of Buoyancy and Thickening of Aging Lithosphere in Mantle Upwelling and Crustal Production Beneath Global Mid‐Ocean Ridge System
Authors: Zha Caicai , Zhang Fan , Lin Jian , Zhang Tao , Tian Jinyu 
Published: May 2024

AbstractBeneath mid‐ocean ridges, mantle upwelling and decompression melting are fundamental processes contributing to the formation of oceanic crust. Previous geodynamic models have suggested that mantle upwelling driven by separating plates can be intensified by thermochemical buoyancy and the thickening of aging lithosphere, resulting in thicker crust. However, the relative contributions of these factors to crustal accretion remain uncertain. We conducted numerical modeling in three scenarios to investigate this: (a) buoyant flow models incorporating age‐dependent lithospheric thickening as a reference; (b) passive flow models incorporating age‐dependent lithospheric thickening to isolate the effect of buoyancy; and (c) passive flow models that neglect age‐dependent lithospheric thickening to isolate its effect. Models are performed under varying potential mantle temperatures (Tp), viscosity structures, and spreading rates. The model‐predicted crustal thickness suggests that both buoyancy and thickening of aging lithosphere increasingly contribute to crustal production as spreading rate decreases. However, given the range of reference mantle viscosities examined here (1019–1020 Pa s), except in ultraslow spreading rates with lower reference viscosity and warmer Tp, the impact of the thickening of aging lithosphere predominates over buoyancy. Furthermore, the relative importance of buoyancy‐induced crustal production increases as spreading rates decrease. Variations in Tp further amplify the variability in crustal thickness compared to that at fast‐spreading ridges where passive upwelling dominates, when combined with 3‐D effects of buoyant flow on altering axial crustal production at ultraslow‐spreading ridge segments. This 4‐D effects of buoyant flow on melt production may explain the observed more variable crustal thickness at ultraslow‐spreading ridges.
Magnitude of and Hydroclimatic Controls on CO2 and CH4 Emissions in the Subtropical Monsoon Pearl River Basin
Authors: Chen Shuai , Ran Lishan , Zhong Jun , Liu Boyi , Yang Xiankun , Yang Ping , Tian Mingyang , Yang Qianqian , Li Si‐Liang , Yan Zhifeng , Fang Nufang 
Published: May 2024

AbstractRivers are important ecosystems for carbon emissions and play a crucial role in the global carbon cycle. However, CO2 and CH4 emissions from subtropical rivers are substantially under‐represented in global‐scale estimates. Here, we explored the regional patterns of riverine CO2 and CH4 dynamics in the Pearl River basin with a subtropical monsoon climate. We found that its CO2 and diffusive CH4 emissions showed a decreasing trend with increasing stream order. Seasonality in CO2 and diffusive CH4 emissions was primarily driven by variations in partial pressure of CO2 (pCO2) and CH4 (pCH4) and gas transfer velocities, which were strongly regulated by hydrology and climate. We further estimated the basin‐wide CO2 and diffusive CH4 fluxes at 17.8 ± 7.4 Tg C yr−1 and 191.5 ± 139.9 Gg C yr−1, respectively. When normalized to the water surface, the mean diffusive fluxes were 790.1 and 8.5 mmol m−2 d−1 for CO2 and CH4, respectively, which were 1.3 and 2.5 times higher than the global mean riverine CO2 and CH4 fluxes, respectively. This suggests that the global significance of subtropical rivers is probably underestimated because their substantially higher CH4 fluxes are unaccounted for. Furthermore, compared with measured pCO2, the alkalinity‐based pCO2 could introduce significant errors by 20% at ∼30% of the sampling sites, underscoring the necessity of direct measurements to reduce uncertainty. This study provides the first estimate of basin‐wide CO2 and diffusive CH4 emissions in the PRB through direct pCO2 and pCH4 measurements, and highlights the role of hydrologic and climatic factors in governing riverine carbon emissions.
On the Formation of Trapped Electron Radiation Belts at Ganymede
Authors: Liuzzo Lucas , Nénon Quentin , Poppe Andrew R. , Stahl Aaron , Simon Sven , Fatemi Shahab 
Published: May 2024

AbstractThis study presents evidence of stably trapped electrons at Jupiter's moon Ganymede. We model energetic electron pitch angle distributions and compare them to observations from the Galileo Energetic Particle Detector to identify signatures of trapped particles during the G28 encounter. We trace electron trajectories to show that they enter Ganymede's mini‐magnetospheric environment, become trapped, and drift around the moon for up to 30 min, in some cases stably orbiting the moon multiple times. Conservation of the first adiabatic invariant partially contributes to energy changes throughout the electrons' orbits, with additional acceleration driven by local electric fields, before they return to Jupiter's magnetosphere or impact the surface. These trapped particles manifest as an electron population with an enhanced flux compared to elsewhere within the mini‐magnetosphere that are detectable by future spacecraft.
Fundamentals for predicting transcriptional regulations from DNA sequence patterns
Authors: Koido Masaru , Tomizuka Kohei , Terao Chikashi 
Published: May 2024

AbstractCell-type-specific regulatory elements, cataloged through extensive experiments and bioinformatics in large-scale consortiums, have enabled enrichment analyses of genetic associations that primarily utilize positional information of the regulatory elements. These analyses have identified cell types and pathways genetically associated with human complex traits. However, our understanding of detailed allelic effects on these elements’ activities and on-off states remains incomplete, hampering the interpretation of human genetic study results. This review introduces machine learning methods to learn sequence-dependent transcriptional regulation mechanisms from DNA sequences for predicting such allelic effects (not associations). We provide a concise history of machine-learning-based approaches, the requirements, and the key computational processes, focusing on primers in machine learning. Convolution and self-attention, pivotal in modern deep-learning models, are explained through geometrical interpretations using dot products. This facilitates understanding of the concept and why these have been used for machine learning for DNA sequences. These will inspire further research in this genetics and genomics field.
m1A inhibition fuels oncolytic virus-elicited antitumor immunity via downregulating MYC/PD-L1 signaling
Authors: Li Shujin , Feng Tian , Liu Yuantong , Yang Qichao , Song An , Wang Shuo , Xie Jun , Zhang Junjie , Yuan Bifeng , Sun Zhijun 
Published: May 2024

AbstractN1-methyladenosine (m1A) RNA methylation is critical for regulating mRNA translation; however, its role in the development, progression, and immunotherapy response of head and neck squamous cell carcinoma (HNSCC) remains largely unknown. Using Tgfbr1 and Pten conditional knockout (2cKO) mice, we found the neoplastic transformation of oral mucosa was accompanied by increased m1A modification levels. Analysis of m1A-associated genes identified TRMT61A as a key m1A writer linked to cancer progression and poor prognosis. Mechanistically, TRMT61A-mediated tRNA-m1A modification promotes MYC protein synthesis, upregulating programmed death-ligand 1 (PD-L1) expression. Moreover, m1A modification levels were also elevated in tumors treated with oncolytic herpes simplex virus (oHSV), contributing to reactive PD-L1 upregulation. Therapeutic m1A inhibition sustained oHSV-induced antitumor immunity and reduced tumor growth, representing a promising strategy to alleviate resistance. These findings indicate that m1A inhibition can prevent immune escape after oHSV therapy by reducing PD-L1 expression, providing a mutually reinforcing combination immunotherapy approach.
Arginine methylation of caspase-8 controls life/death decisions in extrinsic apoptotic networks
Authors: Wohlfromm Fabian , Ivanisenko Nikita V. , Pietkiewicz Sabine , König Corinna , Seyrek Kamil , Kähne Thilo , Lavrik Inna N. 
Published: May 2024

AbstractProcaspase-8 is a key mediator of death receptor (DR)-mediated pathways. Recently, the role of post-translational modifications (PTMs) of procaspase-8 in controlling cell death has received increasing attention. Here, using mass spectrometry screening, pharmacological inhibition and biochemical assays, we show that procaspase-8 can be targeted by the PRMT5/RIOK1/WD45 methylosome complex. Furthermore, two potential methylation sites of PRMT5 on procaspase-8, R233 and R435, were identified in silico. R233 and R435 are highly conserved in mammals and their point mutations are among the most common mutations of caspase-8 in cancer. The introduction of mutations at these positions resulted in inhibitory effects on CD95L-induced caspase-8 activity, effector caspase activation and apoptosis. In addition, we show that procaspase-8 can undergo symmetric di-methylation. Finally, the pharmacological inhibition of PRMT5 resulted in the inhibitory effects on caspase activity and apoptotic cell death. Taken together, we have unraveled the additional control checkpoint in procaspase-8 activation and the arginine methylation network in the extrinsic apoptosis pathway.
New evidence calls into question NICE's endocarditis prevention guidance
Authors: Thornhill Martin , Prendergast Bernard , Dayer Mark , Frisby Ash , Lockhart Peter , Baddour Larry M. 
Published: May 2024

AbstractIn 2008, National Institute for Health and Care Excellence (NICE) guidelines recommended against the use of antibiotic prophylaxis (AP) before invasive dental procedures (IDPs) to prevent infective endocarditis (IE). They did so because of lack of AP efficacy evidence and adverse reaction concerns. Consequently, NICE concluded AP was not cost-effective and should not be recommended. In 2015, NICE reviewed its guidance and continued to recommend against AP. However, it subsequently changed its wording to ‘antibiotic prophylaxis against infective endocarditis is not routinely recommended'. The lack of explanation of what constituted routinely (and not routinely), or how to manage non-routine patients, caused enormous confusion and NICE remained out of step with all major international guideline committees who continued to recommend AP for those at high risk.Since the 2015 guideline review, new data have confirmed an association between IDPs and subsequent IE and demonstrated AP efficacy in reducing IE risk following IDPs in high-risk patients. New evidence also shows that in high-risk patients, the IE risk following IDPs substantially exceeds any adverse reaction risk, and that AP is therefore highly cost-effective. Given the new evidence, a NICE guideline review would seem appropriate so that UK high-risk patients can receive the same protection afforded high-risk patients in the rest of the world.