bluuebunny/crossref_metadata_2025_split huggingface dataset:
Direct magnetic resonance arthrography of the wrist with axial traction: A feasibility study to assess joint cartilage
Authors: Guntern Daniel , Becce Fabio , Richarme Delphine , Palhais Nuno S , Meuli Reto , Theumann Nicolas 
Published: May 2011

AbstractPurpose:To assess the impact of axial traction during acquisition of direct magnetic resonance (MR) arthrography of the wrist with regard to joint space width and amount of contrast material between the opposing cartilage surfaces.Materials and Methods:Fifteen consecutive patients (12 male, mean age 38.1 years) were included in this Institutional Review Board‐approved prospective study. Three‐compartment wrist MR arthrographies were performed between October and December 2009 on a 3 T unit using a fat‐suppressed T1‐weighted isotropic high‐resolution volumetric interpolated breathhold examination (VIBE) sequence in the coronal plane, with and without axial traction (3 kg). Two radiologists measured radiocarpal (radioscaphoid, radiolunate) and midcarpal (lunocapitate, hamatolunate) joint space widths, with and without traction, and assessed the amount of contrast material between the opposing cartilage surfaces using a three‐point scale: 0 = absence, 1 = partial, 2 = complete.Results:With traction, joint space width increased significantly at the radioscaphoid (Δ = 0.78 mm, P < 0.01), radiolunate (Δ = 0.18 mm, P < 0.01), and lunocapitate (Δ = 0.45 mm, P < 0.01) spaces, and both observers detected significantly more contrast material between the cartilage surfaces. At the hamatolunate space, the differences in joint space width (Δ = 0.14 mm, P = 0.54) and amount of contrast material were not significant.Conclusion:Direct wrist MR arthrography with axial traction of 3 kg increases joint space width at the radiocarpal and lunocapitate spaces, and prompts better coverage of the articular cartilage by the contrast material. J. Magn. Reson. Imaging 2011;. © 2011 Wiley‐Liss, Inc.
Skull‐stripping method for brain MRI using a 3D level set with a speedup operator
Authors: Hwang Jinyoung , Han Yeji , Park HyunWook 
Published: May 2011

AbstractPurpose:To extract the brain region from brain magnetic resonance (MR) images using a fast 3D level set method and a refinement process.Materials and Methods:The proposed method introduces a speedup operator to the conventional 3D level set method in order to accelerate the level set evolution. While the processing time for brain extraction is reduced by the speedup operator, the accuracy of brain extraction is also improved by adopting a refinement process.Results:The speedup operator yielded a 75% reduction in the total iteration numbers for the synthesized volume. The proposed method was applied to several datasets and compared with previous methods, ie, BrainVisa, BET, and FreeSurfer. The proposed method provided a Jaccard index of 0.971 ± 0.0114 for the BrainWeb dataset, 0.864 ± 0.035 for the IBSR dataset, and 0.9414 ± 0.0517 for a self‐produced dataset acquired with a 3T MRI system.Conclusion:Utilizing a speedup operator, the proposed method reduced the evolution time. Robust and accurate results for various datasets were obtained in experiments. J. Magn. Reson. Imaging 2011;. © 2011 Wiley‐Liss, Inc.
Does surgery or radiation therapy impact survival for patients with extrapulmonary small cell cancers?
Authors: Grossman Robert A. , Pedroso Felipe E. , Byrne Margaret M. , Koniaris Leonidas G. , Misra Subhasis 
Published: May 2011

AbstractBackground and ObjectivesExtrapulmonary small cell carcinomas (EPSCC) are rare tumors where therapy remains poorly defined. We sought to determine the impact of surgical extirpation and radiation therapy for outcomes of EPSCC.MethodsThe Surveillance, Epidemiology, and End Results (SEER) database was queried for patients with EPSCC which were further categorized by site and evaluated for survival by specific treatment strategy.ResultsWe identified 94,173 patients with small cell carcinoma of which 88,605 (94.1%) and 5,568 (5.9%) had pulmonary small cell carcinoma and EPSCC, respectively. EPSCC patients were subdivided by site with the following proportions: genitourinary (24.1%), gastrointestinal (22.1%), head and neck (7.1%), breast (4%), and miscellaneous (42.7%). Overall EPSSC and specifically gastrointestinal disease had significantly improved median, 5‐ and 10‐year survival with surgery and/or radiation for all stages and sizes. For all EPSCCs multivariate analysis revealed age (>50), gender (female), stage (regional, distant), radiation, and surgery to be independent predictors of survival.ConclusionsAlthough outcomes for EPSCC remains poor, both surgery and radiation is shown to significantly improve median, 5‐ and 10‐year survival rates. EPSCC patients who are potential candidates for surgical resection or radiation therapy may benefit from these treatments. J. Surg. Oncol. 2011; 104:604–612. © 2011 Wiley Periodicals, Inc.
Identification and validation of Kallikrein‐ralated peptidase 11 as a novel prognostic marker of gastric cancer based on immunohistochemistry
Authors: Wen Yu‐Gang , Wang Quan , Zhou Chong‐Zhi , Yan Dong‐Wang , Qiu Guo‐Qiang , Yang Chun , Tang Hua‐Mei , Peng Zhi‐Hai 
Published: May 2011

AbstractBackground and ObjectivesIt is important to identify and validate the differentially expressed genes in gastric cancer to screen diagnostic and/or prognostic tumor markers.MethodscDNA expression microarray, gene set enrichment analysis, and bioinformatics approaches were used to screen the differentially expressed genes between gastric cancer tissues and adjacent non‐cancerous mucosa. A novel candidate prognostic marker, Kallikrein‐related peptidase 11 (KLK11), was validated in 400 Chinese gastric cancer patients. KLK11 expression in gastric cancer tissues was detected using real‐time PCR and Western blot. KLK11 protein expression was further analyzed by immunostaining on tissue microarray, followed with clinicopathological significance and survival analysis.ResultsKLK11 expression was significantly decreased in gastric cancer compared with that in normal gastric mucosa (P < 0.001). Furthermore, KLK11 expression was much lower in poorly differentiated cancer samples than that in well‐differentiated group (P < 0.01). Survival analysis showed that negative KLK11 expression was associated with nearly fivefold increased risk of distant metastasis after curative gastrectomy (HR 4.65, P < 0.01). Multivariate Cox regression analysis showed that KLK11 expression emerged as a significant independent prognostic factor for disease‐free survival and overall survival (P < 0.05).ConclusionsThe results indicated that KLK11 expression was decreased in gastric cancer and might serve as a novel independent prognostic marker. J. Surg. Oncol. 2011; 104:516–524. © 2011 Wiley‐Liss, Inc.
Surgical outcomes for gastric cancer patients with intraperitoneal free cancer cell, but no macroscopic peritoneal metastasis
Authors: Saito Hiroaki , Kihara Kyoichi , Kuroda Hirohiko , Matsunaga Tomoyuki , Tatebe Shigeru , Ikeguchi Masahide 
Published: May 2011

AbstractBackground and ObjectivesGastric cancer patients with intraperitoneal cancer cells have extremely poor prognoses, because they frequently develop peritoneal metastasis. The aim of the current study is to clarify the clinicopathologic characteristics of patients with intraperitoneal free cancer cells who do not have recurrences.MethodsThis study examined 1,985 gastric adenocarcinoma patients who underwent gastrectomies at our institution between January 1975 and December 2000.ResultsThe 5‐year survival rate of advanced gastric cancer patients with intraperitoneal free cancer cells, but no macroscopic peritoneal metastases (P0Cy1), is 15.3%. Multivariate analysis identified only lymph node metastasis as an independent prognostic indicator in P0Cy1 patients. The 5‐year survival rates of P0Cy1 patients were 62.5%, 19.1%, 17.6%, and 9.4% in n0, n1, n2, and n3 patients, respectively. Peritoneal recurrence was observed significantly more often in P0Cy1 patients than in advanced gastric cancer patients without intraperitoneal free cancer cells.ConclusionsOur data indicate that prognoses of P0Cy1 patients without lymph node metastasis are good, whereas the prognoses of those with lymph node metastasis are extremely poor. Therefore, radical surgery and adequate adjuvant chemotherapy should be performed for P0Cy1 patients with no lymph node metastasis. J. Surg. Oncol. 2011; 104:534–537. © 2011 Wiley‐Liss, Inc.
Expression and prognostic significance of CEACAM6, ITGB1, and CYR61 in peripheral blood of patients with gastric cancer
Authors: Zhao Zhong‐Sheng , Li Li , Wang Hui‐Ju , Wang Yuan‐Yu 
Published: May 2011

AbstractBackgroundWe examined CEACAM6, ITGB1, and cyr61 concentrations from patients with gastric cancers (GCs) to assess their clinical application for diagnosing and monitoring diseases.MethodsReal‐time reverse transcription‐polymerase chain reaction was used to detect the expressions of CEA, CEACAM6, ITGB1, IGF1R, CK20, cyr61, and S100A4 in peripheral blood karyocyte from 82 patients with GC, 24 patients with recurrence, and 37 healthy volunteers. Receiver operating characteristics (ROC) curves were constructed.ResultsThere were significant association between these CEACAM6, ITGB1, and cyr61 and TNM Stages and distant metastasis. The AUC of CEACAM6 was 0.884 ± 0.044 (P = 0.0001), the AUC of cyr61 was 0.833 ± 0.047 (P = 0.0001), and the AUC of ITGB1 was 0.838 ± 0.042 (P = 0.0001) by differentiating preoperative GC patients from healthy volunteers from ROC curve analysis. The AUC of CEACAM6 was 0.761 ± 0.066 (P = 0.001), the AUC of CYR61 was 0.762 ± 0.063 (P = 0.001), and the AUC of ITGB1 was 0.824 ± 0.051 (P = 0.0001), by differentiating recurrence of GC from healthy volunteers from ROC curve analysis.ConclusionThe method of detecting the expression of CEACAM6, ITGB1, and CYR61 in peripheral blood of GC patients was more sensitive than CEA, IGF1R, CK20, and S100A4 for the early diagnosis of metastasis and recurrence. J. Surg. Oncol. 2011; 104:525–529. © 2011 Wiley‐Liss, Inc.
A unique deep inferior epigastric artery perforator and implications for a muscle and fascia sparing vertical rectus abdominis myocutaneous flap: A case report
Authors: Iyengar Ajay J. , Rozen Warren M. , Kapila Shivam , Donahoe Simon , Heriot Alexander G. 
Published: May 2011

AbstractDespite the sacrifice of rectus abdominis muscle, the vertical rectus abdominis musculocutaneous (VRAM) flap is still a preferred option for perineal reconstruction. This journal has previously reported on the utility of preoperative computed tomographic angiography (CTA) in this setting to identify cases that are both suitable and unsuitable for rectus abdominis flaps after previous surgery. We report a case which highlights a unique example of the benefits of such imaging, with the largest deep inferior epigastric artery (DIEA) perforator described to date identified on imaging, and used to potentiate a donor‐site sparing procedure. The use of this dominant perforator was able to limit donor site harvest to only a small cuff of anterior rectus sheath and a small segment of rectus abdominis, potentiating a muscle‐sparing and fascia‐sparing VRAM flap for perineal reconstruction. As such, preoperative CTA was found to be a useful tool in identifying a unique anatomical variant in the largest DIEA perforator described to date, and was used to potentiate a muscle‐sparing and fascia‐sparing VRAM flap for perineal reconstruction. © 2011 Wiley‐Liss, Inc. Microsurgery, 2011.
Relationship between lunasin's sequence and its inhibitory activity of histones H3 and H4 acetylation
Authors: Hernández‐Ledesma Blanca , Hsieh Chia‐Chien , de Lumen Ben O. 
Published: May 2011

AbstractScope: Dysfunction of histone acetyltransferases (HATs) or histone deacetylases (HDACs) involved in histones acetylation has been associated with cancer. Inhibitors of these enzymes are becoming potential targets for new therapies.Methods and Results: This study reports by Western‐Blot analysis, that peptide lunasin is mainly an in vitro inhibitor of histone H4 acetylation by P300/cAMP‐response element‐binding protein (CBP)‐associated factor (PCAF), with IC50 values dependent on the lysine position sensitive to be acetylated (0.83 μM (H4‐Lys 8), 1.27 μM (H4‐Lys 12) and 0.40 μM (H4‐Lys 5, 8, 12, 16)). Lunasin is also capable of inhibiting H3 acetylation (IC50 of 5.91 μM (H3‐Lys 9) and 7.81 μM (H3‐Lys 9, 14)). Studies on structure‐activity relationship establish that lunasin's sequence are essential for inhibiting H4 acetylation whereas poly‐D sequence is the main active sequence responsible for H3 acetylation inhibition. Lunasin also inhibits H3 and H4 acetylation and cell proliferation (IC50 of 181μM) in breast cancer MDA‐MB‐231 cells. Moreover, this peptide decreases expression of cyclins and cyclin dependent kinases‐4 and ‐6, implicated in cell cycle pathways.Conclusion: Results from this study demonstrates lunasin's role as modulator of histone acetylation and protein expression that might contribute on its chemopreventive properties against breast cancer.
Urinary N‐methylpyridinium and trigonelline as candidate dietary biomarkers of coffee consumption
Authors: Lang Roman , Wahl Anika , Stark Timo , Hofmann Thomas 
Published: May 2011

AbstractScope: In order to validate the in vivo function of putatively healthy molecules in foods, human intervention studies are required. As the subject's compliance concerning intake or abstinence of a given food is considered mandatory to be monitored by biomarkers, the objective was to identify analytical markers for coffee consumption.Methods and results: Urine samples collected from coffee drinkers were compared with those of non‐coffee drinkers using hydrophilic liquid interaction chromatography (HILIC)/time‐of‐flight mass spectrometry‐based metabolite profiling. Two urinary molecules, found to be contributing most to the dissimilarities between both groups, were identified as N‐methylpyridinium (NMP) and trigonelline and their suitability as coffee‐specific biomarkers was validated by means of a coffee intervention study. After the volunteers (five females and four males) consumed a single dose of coffee, morning urine was collected for 10 days while staying abstinent from any coffee. HILIC‐MS/MS‐stable isotope dilution analysis (SIDA) revealed elevated urinary concentrations of trigonelline and NMP for up to 48 (p=0.001) and 72 h (p=0.002), respectively, after coffee consumption when compared with non‐coffee drinkers.Conclusion: Analysis of urinary NMP allows to check for coffee consumption within a period of 3 days and is proposed as a dietary biomarker which might be used as an analytical probe to control compliance in human intervention studies on coffee.
Mothers in Recovery: An Occupational Perspective
Authors: Martin Linda M. , Smith Melissa , Rogers Jenna , Wallen Tyler , Boisvert Rosemary 
Published: May 2011

AbstractThe purposes of this study were to discover the stories of mothers regarding their journeys to addiction and through recovery, to explore the impact of addiction on the occupational performance of mothers and to identify the factors perceived by these mothers as important in their treatment.A narrative inquiry with thematic analysis of data was utilized; semi‐structured interviews were conducted with 10 women in treatment for alcohol or other drug addiction who were all mothers of minor children.Alterations in occupational identity, occupational performance patterns and performance capacity were revealed. Environmental elements contributing to addiction and those important in recovery were identified and included structure (or the lack of it) and the persons populating the social environment.This qualitative study is not generalizable and should be viewed as relevant to these informants in this context; participants had histories of chronic substance addiction and are not representative of all addictions patients. Findings can be viewed within the context of other research to help enrich the reader's understanding of the complexity of issues.Further research is recommended to test the efficacy of occupational therapy interventions for substance addictions. Possible intervention studies might include those focused on environmental structure, exploration of interests in treatment and co‐occupations of mother and child. Copyright © 2011 John Wiley & Sons, Ltd.
Heterozygous M1V variant of ELA‐2 gene mutation associated with G‐CSF refractory severe congenital neutropenia
Authors: Setty Bhuvana A. , Yeager Nicholas D. , Bajwa Rajinder P. 
Published: May 2011

AbstractSevere congenital neutropenia is an autosomal recessive disorder characterized by maturation arrest at the promyelocyte/myelocyte phase in the bone marrow, absolute neutrophil count <0.5 × 109/L and recurrent bacterial infections. Homozygous mutations of either HAX‐1 or ELA‐2 have been described. We report the case of a premature male infant with congenital neutropenia, associated with multiple infections, refractory to treatment with granulocyte colony stimulating factor who subsequently underwent matched sibling donor stem‐cell transplant. He was found to be heterozygous for the M1V variant of the ELA‐2 gene that we postulate to be causative for his severe neutropenia. Pediatr Blood Cancer 2011; 57: 514–515. © 2011 Wiley‐Liss, Inc.
A novel mutation Gly603Arg of TMPRSS6 in a Korean female with iron‐refractory iron deficiency anemia
Authors: Choi Hyoung Soo , Yang Hye Ran , Song Sang Hoon , Seo Ja‐Young , Lee Ki‐O , Kim Hee‐Jin 
Published: May 2011

AbstractIron‐refractory iron deficiency anemia (IRIDA) is a rare hereditary form of IDA with autosomal recessive inheritance. IRIDA is characterized by hypochromic microcytic anemia unresponsive to oral iron treatment, low transferrin saturation, and a high level of iron‐regulated hormone hepcidin. The genetic background of IRIDA is mutations in the TMPRSS6 gene encoding matriptase‐2 (TMPRSS6) that prevent inactivation of hemojuvelin, an activator of hepcidin transcription. We herein report a Korean female with IRIDA who was compound heterozygous for two mutations in TMPRSS6: a novel missense mutation c.1807G>C (p.Gly603Arg) in the serine protease domain and a known splicing mutation c.863+1G>T (IVS6+1G>T). Pediatr Blood Cancer 2012; 58: 640–642. © 2011 Wiley Periodicals, Inc.
Germline genetic variation and treatment response on CCG‐1891
Authors: Sepe Dana M. , McWilliams Thomas , Chen Jinbo , Kershenbaum Aaron , Zhao Huaqing , La Mei , Devidas Meenakshi , Lange Beverly , Rebbeck Timothy R. , Aplenc Richard 
Published: May 2011

AbstractBackgroundRecent studies suggest that polymorphisms in genes encoding enzymes involved in drug detoxification and metabolism may influence disease outcome in pediatric acute lymphoblastic leukemia (ALL). We sought to extend current knowledge by using standard and novel statistical methodology to examine polymorphic variants of genes and relapse risk, toxicity, and drug dose delivery in standard risk ALL.ProcedureWe genotyped and abstracted chemotherapy drug dose data from treatment roadmaps on 557 patients on the Children's Cancer Group ALL study, CCG‐1891. Fourteen common polymorphisms in genes involved in folate metabolism and/or phase I and II drug detoxification were evaluated individually and clique‐finding methodology was employed for detection of significant gene–gene interactions.ResultsAfter controlling for known risk factors, polymorphisms in four genes: GSTP1*B (HR = 1.94,P = 0.047), MTHFR (HR = 1.61,P = 0.034), MTRR (HR = 1.95,P = 0.01), and TS (3R/4R, HR = 3.69,P = 0.007) were found to significantly increase relapse risk. One gene–gene pair, MTRR A/G and GSTM1 null genotype, significantly increased the risk of relapse after correction for multiple comparisons (P = 0.012). Multiple polymorphisms were associated with various toxicities and there was no significant difference in dose of chemotherapy delivered by genotypes.ConclusionsThese data suggest that various polymorphisms play a role in relapse risk and toxicity during childhood ALL therapy and that genotype does not play a role in adjustment of drug dose administered. Additionally, gene–gene interactions may increase the risk of relapse in childhood ALL and the clique method may have utility in further exploring these interactions. childhood ALL therapy. Pediatr Blood Cancer 2012; 58: 695–700. © 2011 Wiley Periodicals, Inc.
Effects of thermal aging on morphology, resistivity, and thermal properties of extruded high‐density polyethylene/carbon black heating elements
Authors: Seob Jong Young , Han Sien‐Ho , Park Eun‐Soo 
Published: May 2011

AbstractVarious output heating elements were extruded with carbon black (CB)‐filled high‐density polyethylene (HDPE) composites. After thermal aging near melting point of HDPE, the effects of thermal aging on the morphology, resistivity, and thermal properties of the extruded and electron beam (EB)‐irradiated heating elements were examined using scanning electron microscopy (SEM) megohmmeter and differential scanning calorimetry, respectively. The heating element was insulated with a polytetrafluoroethylene tape wrap. The SEM image of HDPE is covered with microvoids that leave a dimple‐like structure on the surface. As the percolation threshold is achieved, CB aggregates are usually located in oval cavities larger than the particles themselves. During the resistivity–temperature cycling test, significant change in resistivity was observed for extruded and EB‐irradiated heaters. In case of thermal‐aged samples at 140°C for 120 h, both heaters showed good stability without pronounced changes in resistivity after resistivity–temperature cycling test. After thermal aged at 140°C for 120 h, the Heater02‐EB composite recovered the oval cavity structure, whereas for Heater02, the amorphous region became narrower and formed a more electroconductive pathway. POLYM. COMPOS., 2011. © 2011 Society of Plastics Engineers
A Comparison of Headspace Solid‐phase Microextraction and Classic Hydrodistillation for the Identification of Volatile Constituents from Thapsia spp. Provides Insights into Guaianolide Biosynthesis in Apiaceae
Authors: Drew Damian Paul , Rasmussen Søren K. , Avato Pinarosa , Simonsen Henrik Toft 
Published: May 2011

ABSTRACTIntroductionThapsia spp. (Apiaceae) are the major natural source of polyoxygenated guaianolide sesquiterpene lactones known as thapsigargins, which induce apoptosis in mammalian cells via a high affinity inhibition of the sarco/endoplasmic reticulum Ca2+ ATPase. The mechanism of biosynthesis of thapsigargins has not been elucidated, and probable biochemical precursors such as hydrocarbon or oxygenated sesquiterpenes have not been identified in previous phytochemical analyses of essential oils from this genus.ObjectiveTo investigate the utility of solid phase micro‐extraction (SPME), when compared with classical essential oil distillates, for identifying potential precursors of guaianolide sesquiterpene lactones from Thapsia garganica L. and Thapsia villosa L. type II.MethodologyA systematic description of the volatile components of roots, flowers, stems and fruits of T. villosa and of root, flower and fruits of T. garganica was constructed via GC‐MS analyses of SPME‐adsorbed compounds and of essential oils obtained through hydrodistillation of the same tissues.ResultsThe sesquiterpenoids δ‐cadinene, α‐ and δ‐guaiene, elemol and guaiols were found to be major volatile constituents of the roots of T. garganica and T. villosa trapped using SPME. In contrast, these sesquiterpenoids were not detected or were at negligible levels in essential oils, where sesquiterpenoids are potentially converted to azulenes during hydrodistillation.ConclusionThe new data reported in this study demonstrates that SPME is a valuable tool for the identification of volatile sesquiterpenes when compared with analysis of essential oils, and we postulate that guaiene is the likely precursor of guaianolide sesquiterpenes from Thapsia. Copyright © 2011 John Wiley & Sons, Ltd.