bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comorbidity of partial and subthreshold ptsd among men and women with eating disorders in the national comorbidity survey‐replication study
Authors: Mitchell Karen S. , Mazzeo Suzanne E. , Schlesinger Michelle R. , Brewerton Timothy D. , Smith Brian N. 
Published: October 2011

AbstractObjective:The comorbidity of posttraumatic stress disorder (PTSD) and eating disorders (EDs) is high among women but has been understudied in men. Little is known about the association between partial or subthreshold PTSD and EDs among women or men.Method:This study included PTSD and ED data from male (n = 2,382) and female (n = 3,310) National Comorbidity Survey‐Replication study participants.Results:The vast majority of women and men with anorexia nervosa, bulimia nervosa (BN), and binge eating disorder (BED) reported a history of interpersonal trauma. Rates of PTSD were significantly higher among women and men with BN and BED. Subthreshold PTSD was more prevalent than threshold PTSD among women with BN and women and men with BED.Discussion:Interpersonal forms of trauma, PTSD, and subthreshold/partial PTSD, were prevalent among men and women with EDs. Findings highlight the importance of assessing for trauma and PTSD in ED patients. © 2011 by Wiley Periodicals, Inc. (Int J Eat Disord 2012)
Convenient Synthesis and Evaluation of a Heptadentate Bifunctional Ligand for Radioimmunotherapy Applications
Authors: Chong Hyun‐Soon , Sun Xiang , Dong Pengfei , Kang Chi Soo 
Published: October 2011

AbstractAn efficient synthetic route to a bifunctional chelating agent C‐NE3TA‐NCS for antibody‐targeted radioimmunotherapy (RIT) applications was developed. Various synthetic methods centered on key reaction steps, including bimolecular cyclization, ring‐opening reactions of aziridine and aziridinium cations, and reductive amination, were explored to optimize the preparation of a tetraaza‐based chelate TANPA and C‐NE3TA analogues. Heptadentate C‐NE3TA‐NCS was conjugated to a tumor‐targeting antibody and compared with hexadentate C‐NOTA‐NCS for radiolabeling reaction kinetics with lanthanides for RIT. The C‐NE3TA–antibody conjugate displayed significantly enhanced complexation kinetics with 90Y compared with the C‐NOTA–antibody conjugate. The synthetic methods for TANPA and C‐NE3TA‐NCS reported herein have broad applications for the preparation of bifunctional and macrocyclic chelating agents.
Asymmetric Synthesis of (+)‐Tanikolide and the β‐Methyl‐Substituted Analogues of (+)‐Tanikolide and (–)‐Malyngolide
Authors: Doran Robert , Duggan Lesley , Singh Surrendra , Duffy Colm D. , Guiry Patrick J. 
Published: October 2011

AbstractThe δ‐lactone‐containing natural product (+)‐tanikolide, a brine shrimp toxin and antifungal compound, was synthesized in nine steps with an overall yield of 26.4 % by employing Sharpless asymmetric epoxidation and ZrCl4‐catalyzed intramolecular acetalization as the key steps. The novel β‐methyl‐substituted analogues of (+)‐tanikolide and(–)‐malyngolide have also been prepared by using the same asymmetric synthetic approach.
Phase II trial of induction chemotherapy followed by surgery for squamous cell carcinoma of the oral tongue in young adults
Authors: Kies Merrill S. , Boatright Dowin H. , Li Guojun , Blumenschein George , El‐Naggar Adel K. , Brandon Gunn G. , Lewin Jan S. , Steinhaus Ganene D. , Sturgis Erich M. 
Published: October 2011

AbstractBackgroundWe conducted a phase II clinical trial of induction chemotherapy followed by surgery ± radiotherapy for squamous cell carcinoma of the oral tongue (SCCOT) in young adults.MethodsFrom September 2001 to October 2004, 23 patients aged 18 to 49 years with clinical T2–3 N0–2 M0 SCCOT and no prior radiotherapy, chemotherapy, or neck dissection underwent induction chemotherapy (paclitaxel, ifosfamide, and carboplatin) followed by glossectomy and neck dissection ± radiotherapy and chemotherapy.ResultsOn final surgical pathology, 9 patients (39%) had a complete/major (2 complete) histologic response at the primary tumor site; 8 patients (35%) had no response or progression. Similarly, 9 patients (39%) had a complete response in the neck or remained node negative; 6 patients (26%) had an increase in nodal category. No treatment‐associated deaths occurred, and toxicity was modest. At a median follow‐up from the end of treatment of 52 months (minimum, 23 months), 10 patients (43%) developed recurrence, and all 10 died of cancer. Crude recurrence/cancer death rates were associated with ≤ a partial response at the tongue (p = .029), poor histologic differentiation (p = .012), and multiple adverse features on final surgical pathology (p = .040).ConclusionResponse rates and overall survival with this induction chemotherapy regimen were limited, but complete/major response at the tongue was associated with excellent prognosis. Additionally, improved patient selection and predictive tumor biomarkers will be needed for induction chemotherapy to be routinely incorporated into the treatment of oral tongue cancer in young adults. © 2011 Wiley Periodicals, Inc. Head Neck, 2012
Water storage in a till catchment. II: Implications of transmissivity feedback for flow paths and turnover times
Authors: Bishop Kevin , Seibert Jan , Nyberg Lars , Rodhe Allan 
Published: October 2011

AbstractThis paper explores the flow paths and turnover times within a catchment characterized by the transmissivity feedback mechanism where there is a strong increase in the saturated hydraulic conductivity towards the soil surface and precipitation inputs saturate progressively more superficial layers of the soil profile. The analysis is facilitated by the correlation between catchment water storage and groundwater levels, which made it possible to model the daily spatial distribution of water storage, both vertically in different soil horizons and horizontally across a 6300‐m2 till catchment. Soil properties and episodic precipitation input dynamics, combined with the influence of topographic features, concentrate flow in the horizontal, vertical, and temporal dimensions. Within the soil profile, there was a vertical concentration of lateral flow to superficial soil horizons (upper 30 cm of the soil), where much of the annual flow occurred during runoff episodes. Overland flow from a limited portion of the catchment can contribute to peak flows but is not a necessary condition for runoff episodes. The spatial concentration of flow, and the episodic nature of runoff events, resulted in a strong and spatially structured differentiation of local flow velocities within the catchment. There were large differences in the time spent by the laterally flowing water at different depths, with turnover times of lateral flow across a 1‐m‐wide soil pedon ranging from under 1 h at 10‐ to 20‐cm depth to a month at 70‐ to 80‐cm depth. In many regards, the hydrology of this catchment appears typical of the hydrology in till soils, which are widespread in Fenno‐Scandia. Copyright © 2011 John Wiley & Sons, Ltd.
Impact of grout curtains on karst groundwater behaviour: an example from the Dinaric karst
Authors: Bonacci Ognjen , Roje‐Bonacci Tanja 
Published: October 2011

AbstractGrout curtains are vertical grout walls installed in the ground. In karst terrains, their construction is primarily connected with dams and reservoirs. Their main role is to increase water tightness and to prevent progressive erosion, blocking possible seepage paths along karst fissures and conduits. In this article, changes in the behaviour of the groundwater level (GWL) and the water temperature in nine deep piezometers, which were caused by the construction of a grout curtain at the Đale Reservoir on the Cetina River (Croatia), were analysed. The total length of the grout curtain is 3966 m. It spreads 120 m below the dam. The most analysed data are from the period after the dam had been built. Only few data and figures concern the comparison between pre‐ and post‐dam periods. The hourly data of the GWL and the water temperature were analysed for the period between 1 September 2008 at 02:00 h to 31 December 2009 at 23:00 h (11 687 h total) in six deep piezometers (marked in the text and figures as 1, 2, 3, 4, 5 and 6). For three piezometers (marked in the text and figures as A, B and C), some discontinuous measurements of the GWL and the water temperature were available for analysis. The construction of the grout curtain made strong, sudden and possibly dangerous changes to the characteristics of the aquifer and the circulation of groundwater in the local area. Special attention is paid to analyses of the behaviour of the hourly GWL data measured in the piezometers pairs (two neighbouring piezometers, one inside and the other outside of the grout curtain). During more than 80% of the analysed period, the GWL was higher in the piezometer inside the grout curtain than the one outside of it. The intensity and range of the dynamics of GWL was higher in piezometer outside the grout curtain than the inside ones. After the construction of the grout curtain, the maximum measured hydrostatic pressure on some parts of the grout curtain was approximately 40 m. It changes quickly in both time and direction. The water temperature was found to be similar in all of the measured piezometers, and it varies between 10.2 and 15.7 °C with an average value of 12.7 °C. Copyright © 2011 John Wiley & Sons, Ltd.
Late‐summer thermal regime of a small proglacial lake
Authors: Richards J. , Moore R. D. , Forrest A. L. 
Published: October 2011

AbstractThis study was motivated by an interest in understanding the potential effects of climate change and glacier retreat on late summer water temperatures in alpine areas. Fieldwork was carried out between July and September 2007 at Place Lake, located below Place Glacier in the southern Coast Mountains of British Columbia. Place Lake has an area of 72 000 m2, a single inlet and outlet channel, and an approximate residence time of 4 days. Warming between the inlet and outlet of the lake ranged up to 3 °C and averaged 1.8 °C, which exceeds the amount of warming that occurred over the 1 km reach of Place Creek between the lake outlet and tree line. Over a 23‐day period, net radiation totalled about 210 MJ·m–2, with sensible heat flux adding another 56 MJ m‐2. The latent heat flux consumed about 8% of the surface heat input. The dominant heat sink was the net horizontal advection associated with lake inflow and outflow. Early in the study period, temperatures between the surface and 6‐m depth were dominantly at or above 4 °C and were generally neutral to thermally stable, whereas temperatures decreased with depth below 6 m and exhibited irregular sub‐diurnal variations. The maximum outflow temperature of almost 7 °C occurred in this period. We hypothesize that turbidity currents associated with cold, sediment‐laden glacier discharge formed an underflow and influenced temperatures in the deeper portion of the lake but did not mix with the upper layers. Later in the study period, the lake was dominantly well mixed with some near‐surface stability associated with nocturnal cooling. Further research is required to examine the combined effects of sediment concentrations and thermal processes on mixing in small proglacial lakes to make projections of the consequences of glacier retreat on alpine lake and stream temperatures. Copyright © 2011 John Wiley & Sons, Ltd.
Hydrochemical characteristics and salinization processes of groundwater in the shallow aquifer of Eastern Laizhou Bay, China
Authors: Wen Xiaohu , Diao Meina , Wang De , Gao Meng 
Published: October 2011

AbstractGroundwater salinization has become a crucial environmental problem worldwide and is considered the most widespread form of groundwater contamination in the coastal zone. In this study, a hydrochemical investigation was conducted in the eastern coastal shallow aquifer of Laizhou Bay to identify the hydrochemical characteristics and the salinity of groundwater using ionic ratios, deficit or excess of each ions, saturation indices and factor analysis. The results indicate that groundwater in the study area showed wide ranges and high standard deviations for most of hydrochemical parameters and can be classified into two hydrochemical facies, Ca2+‐Mg2+‐Cl‐ facies and Na+‐Cl‐ facies. The ionic ratio, deficit or excess of each ions and SI were applied to evaluate hydrochemical processes. The results obtained indicate that the salinization processes in the coastal zones were inverse cation exchange, dissolution of calcite and dolomite, and intensive agricultural practices. Factor analysis shows that three factors were determined (Factor 1: TDS, EC, Cl‐, Mg2+, Na+, K+, Ca2+ and SO42‐; Factor 2: HCO3‐ and pH; Factor 3: NO3‐ and pH), representing the signature of seawater intrusion in the coastal zone, weathering of water–soil/rock interaction, and nitrate contamination, respectively. Copyright © 2011 John Wiley & Sons, Ltd.
Evaluation of an empirical orthogonal function–based method to downscale soil moisture patterns based on topographical attributes
Authors: Busch Frederick A. , Niemann Jeffrey D. , Coleman Michael 
Published: October 2011

AbstractSoil moisture influences many hydrologic applications including agriculture, land management and flood prediction. Most remote‐sensing methods that estimate soil moisture produce coarse resolution patterns, so methods are required to downscale such patterns to the resolutions required by these applications (e.g. 10‐ to 30‐m grid cells). At such resolutions, topography is known to affect soil moisture patterns. Although methods have been proposed to downscale soil moisture based on topography, they usually require the availability of past high‐resolution soil moisture patterns from the application region. The objective of this article is to determine whether a single topographic‐based downscaling method can be used at multiple locations without relying on detailed local observations. The evaluated downscaling method is developed on the basis of empirical orthogonal function (EOF) analysis of space–time soil moisture data at a reference catchment. The most important EOFs are then estimated from topographic attributes, and the associated expansion coefficients are estimated on the basis of the spatial‐average soil moisture. To test the portability of this EOF‐based method, it is developed separately using four data sets (Tarrawarra, Tarrawarra 2, Cache la Poudre and Satellite Station), and the relationships that are derived from these data sets to estimate the EOFs and expansion coefficients are compared. In addition, each of these downscaling methods is applied not only for the catchment where it was developed but also to the other three catchments. The results suggest that the EOF downscaling method performs well for the location where it is developed, but its performance degrades when applied to other catchments. Copyright © 2011 John Wiley & Sons, Ltd.
Osteochondral interface regeneration of the rabbit knee with macroscopic gradients of bioactive signals
Authors: Dormer Nathan H. , Singh Milind , Zhao Liang , Mohan Neethu , Berkland Cory J. , Detamore Michael S. 
Published: October 2011

AbstractTo date, most interfacial tissue engineering approaches have used stratified designs, in which there are two or more discrete layers comprising the interface. Continuously graded interfacial designs, where there is no discrete transition from one tissue type to another, are gaining attention as an alternative to stratified designs. Given that osteochondral regeneration holds the potential to enhance cartilage regeneration by leveraging the healing capacity of the underlying bone, we endeavored to introduce a continuously‐graded approach to osteochondral regeneration. The purpose of this study was thus to evaluate the performance of a novel gradient‐based scaffolding approach to regenerate osteochondral defects in the New Zealand White rabbit femoral condyle. Bioactive plugs were constructed from poly(D,L‐lactic‐co‐glycolic acid) microspheres with a continuous gradient transition between cartilage‐promoting and bone‐promoting growth factors. At 6 and 12 weeks of healing, results suggested that the implants provided support for the neo‐synthesized tissue, and the gradient in bioactive signaling may have been beneficial for bone and cartilage regeneration compared to the blank control implant, as evidenced by histology. In addition, the effects of preseeding gradient scaffolds with umbilical cord mesenchymal stromal cells (UCMSCs) from the Wharton's jelly of New Zealand White rabbits were evaluated. Results indicated that there may be regenerative benefits to prelocalizing UCMSCs within scaffold interiors. The inclusion of bioactive factors in a gradient‐based scaffolding design is a promising new treatment strategy for defect repair in the femoral condyle. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.
Synthesis and characterization of injectable, thermosensitive, and biocompatible acellular bone matrix/poly(ethylene glycol)‐poly (ε‐caprolactone)‐poly(ethylene glycol) hydrogel composite
Authors: Ni Pei‐Yan , Fan Min , Qian Zhi‐Yong , Luo Jing‐Cong , Gong Chang‐Yang , Fu Shao‐Zhi , Shi Shuai , Luo Feng , Yang Zhi‐Ming 
Published: October 2011

AbstractIn orthopedic tissue engineering, the extensively applied acellular bone matrix (ABM) can seldom be prefabricated just right to mold the cavity of the diverse defects, might induce severe inflammation on account of the migration of small granules and usually bring the patients great pain in the treatment. In this study, a new injectable thermosensitive ABM/PECE composite with good biocompatibility was designed and prepared by adding the ABM granules into the triblock copolymer poly(ethylene eglycol)‐poly(ε‐caprolactone)‐poly(ethylene eglycol) (PEG‐PCL‐PEG, PECE). The PECE was synthesized by ring‐opening copolymerization and characterized by 1H NMR. The ABM was prepared by acellular treatment of natural bone and ground to fine granules. The obtained ABM/PECE composite showed the most important absorption bands of ABM and PECE copolymer in FT‐IR spectroscopy and underwent sol–gel phage transition from solution to nonflowing hydrogel at 37°C. SEM results indicated that the ABM/PECE composite with different ABM contents all presented similar porous 3D structure. ABM/PECE composite presented mild cytotoxicity to rat MSCs in vitro and good biocompatibility in the BALB/c mice subcutis up to 4 weeks. In conclusion, all the results confirmed that the injectable thermosensitive ABM/PECE composite was a promising candidate for orthopedic tissue engineering in a minimally‐invasive way. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.
Characterization of norovirus strains in Australian children from 2006 to 2008: Prevalence of recombinant strains
Authors: Mahar Jackie E. , Kirkwood Carl D. 
Published: October 2011

AbstractNoroviruses are highly infectious and are the most common cause of gastroenteritis outbreaks. Genotype II.4 strains have been the dominant type identified in adults, however the genotype distribution in children is less clearly defined. This study aimed to detect and genotype norovirus strains infecting children hospitalized with acute gastroenteritis in Melbourne, Australia from 2006 to 2008. Stool samples were collected from 272 children admitted to the Royal Children's Hospital, Melbourne, Australia, with non‐rotavirus acute gastroenteritis between April 2006 and December 2008. Using RT‐PCR, norovirus was detected in 36% of samples. Strains were genetically characterized via analysis of regions from both the capsid gene and the RNA dependent RNA polymerase (RdRp) gene, to investigate genotype distribution and incidence of recombination. Typing based on the capsid gene (n = 70) detected GII.4 (49%) and GII.3 (46%) as the most predominant genotypes. Strains with a GII.4 capsid were usually assigned a GII.4 RdRp, whereas most strains identified as GII.3 based on capsid typing were assigned a GIIb RdRp (71%). The GII.3/GIIb represent recombinant strains. Sequence analysis of the putative recombination breakpoint was performed for three representative suspected recombinants: GII.3/GIIb (n = 2) and GII.3/GII.12 (n = 1). Recombination analysis confirmed these strains as recombinants and identified putative breakpoints adjacent to the ORF1/ORF2 junction. This study highlights the importance of norovirus infection as a cause of pediatric gastroenteritis. It also reinforces the high circulation of recombinant strains causing disease in children, particularly the GII.3/GIIb strain. J. Med. Virol. 83:2213–2219, 2011. © 2011 Wiley Periodicals, Inc.
High prevalence of human papillomaviruses in fresh frozen breast cancer samples
Authors: Antonsson Annika , Spurr Terrence P. , Chen Alice C. , Francis Glenn D. , McMillan Nigel A.J. , Saunders Nicholas A. , Law Michael , Bennett Ian C. 
Published: October 2011

AbstractWhile the etiology of breast cancer remains enigmatic, some recent reports have examined the role of human papillomavirus (HPV) in breast carcinogenesis. The purpose of this study was to determine the prevalence of HPV in breast cancer tissue using PCR analysis and sequencing. Fifty‐four (54) fresh frozen breast cancers samples that were removed from a cohort of breast cancer patients were analyzed. Samples were tested for HPV using comprehensive PCR primers, and in situ hybridization was performed on paraffin embedded tissue sections. Findings were correlated with clinical and pathological characteristics. The HPV DNA prevalence in the breast cancer samples was 50% (27/54) with sequence analysis indicating all cases to be positive for HPV‐18 type. While HPV patients were slightly younger, no correlation was noted for menopausal status or family history. HPV positive tumors were smaller with earlier T staging and demonstrated lesser nodal involvement compared to HPV negative cancers. In situ hybridization analyses proved negative. The high proportion of HPV positive breast cancers detected in this series using fresh frozen tissues cannot be dismissed, however the role of HPV in breast carcinogenesis remains unclear and may ultimately be ascertained by monitoring future breast cancer incidence amongst women vaccinated against high risk HPV types. J. Med. Virol. 83:2157–2163, 2011. © 2011 Wiley Periodicals, Inc.
Intrathecal antibody production in two cases of yellow fever vaccine associated neurotropic disease in Argentina
Authors: Pires‐Marczeski Fanny Clara , Martinez Valeria Paula , Nemirovsky Corina , Padula Paula Julieta 
Published: October 2011

AbstractDuring the period 2007–2008 several epizootics of Yellow fever with dead of monkeys occurred in southeastern Brasil, Paraguay, and northeastern Argentina. In 2008 after a Yellow fever outbreak an exhaustive prevention campaign took place in Argentina using 17D live attenuated Yellow fever vaccine. This vaccine is considered one of the safest live virus vaccines, although serious adverse reactions may occur after vaccination, and vaccine‐associated neurotropic disease are reported rarely. The aim of this study was to confirm two serious adverse events associated to Yellow fever vaccine in Argentina, and to describe the analysis performed to assess the origin of specific IgM against Yellow fever virus (YFV) in cerebrospinal fluid (CSF). Both cases coincided with the Yellow fever vaccine‐associated neurotropic disease case definition, being clinical diagnosis longitudinal myelitis (case 1) and meningoencephalitis (case 2). Specific YFV antibodies were detected in CSF and serum samples in both cases by IgM antibody‐capture ELISA. No other cause of neurological disease was identified. In order to obtain a conclusive diagnosis of central nervous system (CNS) infection the IgM antibody index (AIIgM) was calculated. High AIIgMvalues were found in both cases indicating intrathecal production of antibodies and, therefore, CNS post‐vaccinal YFV infection could be definitively associated to YFV vaccination. J. Med. Virol. 83:2208–2212, 2011. © 2011 Wiley Periodicals, Inc.