bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Enrichment Study of the Minnesota Twin Family Study: Increasing the Yield of Twin Families at High Risk for Externalizing Psychopathology
Authors: Keyes Margaret A. , Malone Stephen M. , Elkins Irene J. , Legrand Lisa N. , McGue Matt , Iacono William G. 
Published: October 2009

AbstractThe Enrichment Study (ES) was designed to extend the Minnesota Twin Family Study (MTFS) by oversampling 11-year-old twins at especially high risk for substance use disorders by virtue of having a childhood disruptive disorder. The sample was ascertained from Minnesota birth records. To identify high-risk twins, we conducted telephone screening interviews for parent-reported symptoms of attention-deficit/hyperactivity disorder (ADHD) and conduct disorder (CD) as well as indications of academic disengagement. Twins who exceeded a predetermined threshold were invited to participate. To facilitate comparison with the previously ascertained MTFS participants, a random sample of 11-year-old twins was also recruited. As part of the ES study, 499 twin pairs, and their parents, visited the University of Minnesota, where each participant completed a clinical interview, psychophysiological evaluation, and thorough assessment of environmental risk. We were highly successful in recruiting at-risk twins; 52% of the screened male twins and 41% of the screened females met criteria for a diagnosis of ADHD, CD, or oppositional defiant disorder (ODD). At the pair level, 63% of the screened pairs had at least one member with a childhood disruptive disorder. This article provides an overview of the study design and includes a review of recent findings using this sample of twins.
X Chromosome Inactivation Pattern is not Associated With Interindividual Variations in Thyroid Volume: A Study of Euthyroid Danish Female Twins
Authors: Brix Thomas Heiberg , Hansen Pia Skov , Bennedbæk Finn Noe , Bonnema Steen Joop , Kyvik Kirsten Ohm , Ørstavik Karen Helene , Hegedüs Laszlo 
Published: October 2009

AbstractAhigher frequency of skewed X chromosome inactivation (XCI) is found in patients with autoimmune thyroid disease (AITD) than in controls. Although goitre is often present in AITD, a recent study failed to show an association between XCI and clinically overt nontoxic goitre. However, the etiology of overt goitre is complex, and the mechanisms influencing thyroid volume may involve fewer factors than the mechanisms underlying overt goitre. In order to examine the impact of XCI on thyroid volume in euthyroid females, we studied whether within cohort (n= 138) and within twin pair (n= 69) differences in XCI are correlated with differences in thyroid volume. XCI was determined by PCR analysis of a polymorphic CAG repeat in the first exon of the androgen receptor gene. Thyroid volume was determined by ultrasound. Neither in the within cohort nor in the within twin pair analysis could we demonstrate a statistically significant association between XCI and thyroid volume: Regression coefficient (β) = 0.023 (95% confidence interval, –0.062–0.108),p= 0.592 and β = 0.038 (–0.080–0.156),p= 0.521, respectively. Controlling for potential confounders such as zygosity, age, TSH, smoking habits and use of oral contraceptives did not change the findings. In conclusion, in a sample of euthyroid Danish female twins, we found no evidence of a relationship between XCI pattern and thyroid volume.
Genetic Influences on Individual Differences in Nicotine Glucuronidation
Authors: Lessov-Schlaggar Christina N. , Benowitz Neal L. , Jacob Peyton , Swan Gary E. 
Published: October 2009

AbstractNicotine and its primary oxidative metabolites are metabolized in part by glucuronidation. Genetic variation in UGT isoenzymes that catalyze glucuronidation activity suggests that variation in glucuronidation rate is in part genetically determined. The relative contribution of genetic and environmental sources to individual differences in the rate of glucuronidation of nicotine, cotinine, andtrans-3'-hydroxycotinine was estimated in a twin study of nicotine pharmacokinetics. Glucuronidation rate was defined using measures that either accounted for variability in renal clearance or assumed the same relative renal clearance of parent drug and glucuronide conjugate across individuals. The former definition resulted in highly correlated nicotine and cotinine glucuronidation measures that were substantially influenced by the combined effect of additive (heritable) and non-additive (dominant and epistatic) genetic effects. These findings suggest that genetic variation in UGT isoenzymes that act in additive and interactive ways is an important determinant of individual variability in nicotine and cotinine metabolism via glucuronidation pathways.
Estimating the Heritability of Hair Curliness in Twins of European Ancestry
Authors: Medland Sarah E. , Zhu Gu , Martin Nicholas G. 
Published: October 2009

AbstractRecent studies in Asian populations have identified variants in theEDARandFGFR2genes that arose following the divergence of Asians and Europeans and are associated with thick straight hair. To date no genetic variants have been identified influencing hair texture in Europeans. In the current study we examined the heritability of hair curliness in three unselected samples of predominantly European ancestry (NS1= 2717;NS2= 3904;NS3= 5079). When rated using a three point scale (Straight/Wavy/Curly) males were ~5% more likely to report straight hair than females and there were suggestions in the data that curliness increased slightly with age. Across samples significant additive and dominant genetic influences were detected resulting in a broad sense heritability of 85–95%. Given the magnitude and the specificity of the EDAR effect on hair morphology in Asian populations we are hopeful that future association studies will detect similar genetic influences in European populations.
Effects of selected key chromophores on cellulose integrity upon bleaching 10th EWLP, Stockholm, Sweden, August 25–28, 2008
Authors: Krainz Karin , Potthast Antje , Suess Ulrich , Dietz Thomas , Nimmerfroh Norbert , Rosenau Thomas 
Published: October 2009

Abstract
In the present study, three representative residual chromophores recently isolated from highly bleached and aged pulps, 2,5-dihydroxy-[1,4]-benzoquinone (1), 5,8-dihydroxy-[1,4]-naphthoquinone (2), and 2,6-dihydroxy-acetophenone (3), were selected to study their effects with regard to cellulose degradation under bleaching conditions, similar to those typically used in the pulp and paper industries.
Revisiting the USPTO's Examination Guidelines for Gene Patents: Congressional Inaction, USPTO Restraint, and Judicial Remedy
Authors: Drabiak-Syed Katherine 
Published: October 2009

AbstractSince 1992 the USPTO has been issuing gene patents based on the premise that a gene sequence consists of patentable subject matter and meets the requirements set forth in 35 USC § 101 et seq. Various scholars and international societies have recently questioned the USPTO's stance, raising both normative concerns as well substantive problems associated with the number and scope of gene patents on the availability and access of diagnostic tests as well as their effect on scientific innovation and method validation. This paper examines recent Congressional testimony, USPTO's deference to Congress' inaction, and the possibility of judicial remedy through currently pending litigation of
The Growing Role of Genetic Professionals in Forensic DNA
Authors: Pinto Cristina 
Published: October 2009

AbstractThrough the last decade there was an enormous revolution in the field of forensic genetic.The Author reviews some of the methodologies used in the definitions of DNA profiling tackling the principles of recombinant DNA techniques. The potentiality of polymorphic DNA fragments in vertebrates is focused as well as the revolution implied in forensic medicine. The resource to DNA-DNA hybridization combined to oligonucleotide probes is emphasized leading to the production of an individual bar code with the resource of genomic polymorphism which leads to a pattern known as genetic fingerprinting. Other techniques for individual identification and paternity testing are focused as well as the use of short tandem repeats (STR's). Mitochondrial DNA sequencing use to complement nuclear DNA typing may also be profitable in certain instances. Relevant problems within the context of the use of these techniques in forensic medicine and law suits are discussed. Final considerations viewing the resource to DNA technology within the scope of the last two decades are referred regarding the resource to DNA profiles not only in the US but in Europe in general and in Portugal in special having lead to compensation and uncover of justice errors.
A constraint on copy deletion
Authors: Trinh Tue 
Published: October 2009

Abstract
One version of the copy theory of movement holds that syntactic traces are full-fledged constituents which undergo a PF-deletion rule. In this paper, I propose a constraint on this rule. The constraint says that the lower copy of a chain can be phonologically deleted only if it ends an XP. I show that this constraint, conjoined with proposals that have been made concerning phrase structure (Chomsky, Bare phrase structure, 1994) and the semantics of NP in classifier languages (Chierchia, Natural Language Semantics 6: 339–405, 1998), explains a variety of facts in Dutch, German, Hebrew, Norwegian, Swedish and Vietnamese.
The Zen of Anarchy: Japanese Exceptionalism and the Anarchist Roots of the San Francisco Poetry Renaissance
Authors: Brown James 
Published: October 2009

AbstractThis essay explores the political origins and implications of Beat Zen anarchism, a cultural phenomenon located in the intersection between American anarchist traditions and Zen Buddhism in the San Francisco Poetry Renaissance. Focusing on the writings of D. T. Suzuki, Alan Watts, Gary Snyder, and Philip Whalen, it shows how Beat Zen emerged not primarily from an Orientalist appropriation of “the East” but rather from an Occidentalist, Japanese-centered criticism of American materialism that followed from the complex legacy of the World’s Parliament of Religions at the 1893 World's Columbian Exposition. In staking their claims to Zen, in other words, Philip Whalen and Gary Snyder—the Beat poets on whom this essay focuses—along with Alan Watts expressed the views not of cultural imperialists, as one might suppose, but of converts to what they regarded as a superior way of life.The Beat adoption of Zen intersected with a broadly libertarian and specifically anarchist social milieu in San Francisco that congregated around Kenneth Roxroth's Libertarian Club and Anarchist Circle. The individualist, anti-statist, and anarchist political outlooks of Beat Zen anarchists were directly confirmed by the writings of D. T. Suzuki, who presented Zen as a practice of personal liberation from cultural conditioning. Suzuki's rhetorical approach—which treated Japanese Zen as both a pinnacle of Asian civilization and a key to the liberation of Western humanity from its stifling and destructive rationalism—was informed by Meiji-era Japanese nationalism and exceptionalism and by the universalism that Buddhist missionaries brought to their explanations of Zen to Westerners. Arguing that Beat Zen poets, in adopting Buddhism as it was presented to them, were foremost Occidentalist rather than Orientalist in outlook, this essay concludes that the Beat Zen anarchist cultural formation suggests a libertarian alternative to Orientalism and also reconfigures common conceptions of American radical literary history as primarily Marxistinflected.
Almost everywhere elimination of probability quantifiers
Authors: Keisler H. Jerome , Lotfallah Wafik Boulos 
Published: October 2009

AbstractWe obtain an almost everywhere quantifier elimination for (the noncritical fragment of) the logic with probability quantifiers, introduced by the first author in [10]. This logic has quantifiers like ∃≥3/4y which says that “for at least 3/4 of all y”. These results improve upon the 0-1 law for a fragment of this logic obtained by Knyazev [11]. Our improvements are:1. We deal with the quantifier ∃≥ry, where y is a tuple of variables.2. We remove the closedness restriction, which requires that the variables in y occur in all atomic subformulas of the quantifier scope.3. Instead of the unbiased measure where each model with universe n has the same probability, we work with any measure generated by independent atomic probabilities PR for each predicate symbol R.4. We extend the results to parametric classes of finite models (for example, the classes of bipartite graphs, undirected graphs, and oriented graphs).5. We extend the results to a natural (noncritical) fragment of the infinitary logic with probability quantifiers.6. We allow each PR, as well as each r in the probability quantifier (∃≥ry), to depend on the size of the universe.
Some remarks on generic structures
Authors: Evans David M. , Wong Mark Wing Ho 
Published: October 2009

AbstractWe show that the ℵ0-categorical structures produced by Hrushovski's predimension construction with a control function fit neatly into Shelah's SOPn hierarchy: if they are not simple, then they have SOP3 and NSOP4. We also show that structures produced without using a control function can be undecidable and have SOP.
A note on defining transcendentals in function fields
Authors: Fehm Arno , Geyer Wulf-Dieter 
Published: October 2009

AbstractThe work [11] deals with questions of first-order definability in algebraic function fields. In particular, it exhibits new cases in which the field of constant functions is definable, and it investigates the phenomenon of definable transcendental elements. We fix some of its proofs and make additional observations concerning definable closure in these fields.
Heirs of box types in polynomially bounded structures
Authors: Tressl Marcus 
Published: October 2009

AbstractA box type is an n-type of an o-minimal structure which is uniquely determined by the projections to the coordinate axes. We characterize heirs of box types of a polynomially bounded o-minimal structure M. From this, we deduce various structure theorems for subsets of Mk, definable in the expansion of M by all convex subsets of the line. We show that after naming constants, is model complete provided M is model complete.
The strength of the rainbow Ramsey Theorem
Authors: Csima Barbara F. , Mileti Joseph R. 
Published: October 2009

AbstractThe Rainbow Ramsey Theorem is essentially an “anti-Ramsey” theorem which states that certain types of colorings must be injective on a large subset (rather than constant on a large subset). Surprisingly, this version follows easily from Ramsey's Theorem, even in the weak system RCA0 of reverse mathematics. We answer the question of the converse implication for pairs, showing that the Rainbow Ramsey Theorem for pairs is in fact strictly weaker than Ramsey's Theorem for pairs over RCA0. The separation involves techniques from the theory of randomness by showing that every 2-random bounds an ω-model of the Rainbow Ramsey Theorem for pairs. These results also provide as a corollary a new proof of Martin's theorem that the hyperimmune degrees have measure one.
d-computable categoricity for algebraic fields
Authors: Miller Russell 
Published: October 2009

AbstractWe use the Low Basis Theorem of Jockusch and Soare to show that all computable algebraic fields are d-computably categorical for a particular Turing degree d with d′ = 0″, but that not all such fields are 0′-computably categorical. We also prove related results about algebraic fields with splitting algorithms, and fields of finite transcendence degree over ℚ.
The modalμ-calculus hierarchy over restricted classes of transition systems
Authors: Alberucci Luca , Facchini Alessandro 
Published: October 2009

AbstractWe study the strictness of the modalμ-calculus hierarchy over some restricted classes of transition systems. First, we prove that over transitive systems the hierarchy collapses to the alternation-free fragment. In order to do this the finite model theorem for transitive transition systems is proved. Further, we verify that if symmetry is added to transitivity the hierarchy collapses to the purely modal fragment. Finally, we show that the hierarchy is strict over reflexive frames. By proving the finite model theorem for reflexive systems the same results holds for finite models.
Logical aspects of rates of convergence in metric spaces
Authors: Briseid Eyvind Martol 
Published: October 2009

AbstractIn this paper we develop a method for finding, under general conditions, explicit and highly uniform rates of convergence for the Picard iteration sequences for selfmaps on bounded metric spaces from ineffective proofs of convergence to a unique fixed point. We are able to extract full rates of convergence by extending the use of a logical metatheorem recently proved by Kohlenbach. In recent case studies we were able to find such explicit rates of convergence in two concrete cases. Our novel method now provides an explanation in logical terms for these findings. This amounts, loosely speaking, to general conditions under which we in this specific setting can transform a ∀∃∀-sentence into a ∀∃-sentence via an argument involving product spaces. This reduction in logical complexity allows us to use the existing machinery to extract quantitative bounds of the sort we need.
Silver sorption on acrylic copolymers functionalized with amines. Equilibrium and kinetic studies
Authors: Buhaceanu Rodica , Sarghie Ioan , Barsanescu Adriana , Dulman Viorica , Bunia Ioan 
Published: October 2009

Abstract
The sorption capacity of three weak base ion exchangers based on acrylic copolymers functionalized with ethylenediamine, triethylenetetramine and N, N- dimethylamino propylamine for Ag(I) ions was evaluated. Adsorption experiments were carried out by batch method. The effect of pH, crosslinking degree of copolymers, amount of sorbent, initial ion concentration, contact time and temperature was studied. The parameters which characterize the retention process were estimated using Langmuir and Freundlich isotherm models, the best fitting being for the first model. Kinetic data were fitted to pseudo-first order, pseudo-second order and intraparticle diffusion models. Experimental data were in good agreement with the pseudo second order.
Catalytic reduction of NO by CO over Pd — doped Perovskite-type catalysts
Authors: Khristova Mariana , Petrović Srdjan , Terlecki-Baričević Ana , Mehandjiev Dimitar 
Published: October 2009

Abstract
The perovskite type oxides (nominal formula LaTi0.5Mg0.5O3) with addition of Pd were prepared by annealing the ethanol solution of precursors in nitrogen flow at 1200°C and characterized by X-ray powder diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and temperature programmed desorption of NO (NO-TPD). Their activity was evaluated for NO reduction by CO under stoichiometric and oxidizing conditions and for direct decomposition of NO. Pd substituted samples exhibited high NO reduction activity and selectivity towards N2. Nearly complete elimination of NO was achieved at 200°C. Two simultaneous reactions, NO reduction by CO and direct decomposition of NO as well as two forms of NO adsorption were observed on the surface of Pd substituted perovskite samples. The distribution of Pd in different catalytically active sites or complexes on at the catalyst surface may be responsible for the proceeding of two reactions: NO reduction with CO and direct NO decomposition.
Organic / inorganic bioactive materials Part I: Synthesis, structure and in vitro assessment of collagen/silicocarnotite biocoatings
Authors: Hristov Vladimir , Radev Lachezar , Samuneva Bisserka , Apostolov Georgi 
Published: October 2009

Abstract
The silicocarnotite, as an inorganic part of the coatings, has been synthesized using a polystep sol-gel method. The chemical composition of the prepared silicocarnotite sol is described as 58.12 CaO, 29.42 P2O5, 12.45 SiO2 (wt%), where Ca/P+Si = 1,67. The acid soluble type I collagen, as an organic part of the obtained coatings, was mixed with silicocarnotite powder in a weight ratio of 25:75 and 75:25 weight ratio without cross-linkage. The acidity of the obtained mixture was readjust with 25% NH4OH to pH = 9.0. The mixture was then dried at 37°C for 12 h.
The growth of B-type carbonate containing hydroxyapatite (B-type CO3HA) in which CO3
2+→PO4
3− on the surface of collagen/silicocarnotite coatings soaked in 1.5 simulated body fluid (1.5 SBF) was observed. The nucleation of B-type CO3HA was estimated on the obtained coatings after 3 days immersion in 1.5 SBF. The negatively charged carboxylate groups from the collagen surface may be responsible for the HA deposition. This was confirmed by the “red shift” of carboxylate groups of collagen molecules in the FTIR spectra. After soaking in 1.5 SBF, the morphology of prepared coatings and HA formation was observed by SEM.
One step synthesis of Diflunisal using a Pd-diamine complex
Authors: Kylmälä Tuula , Tois Jan , Xu Youjun , Franzén Robert 
Published: October 2009

Abstract
Diflunisal and Felbinac, two FDA-approved NSAIDs and other biphenyl carboxylic acids were prepared in one step by a simple and clean Suzuki cross-coupling reaction using an easily synthesized, air and moisture stable, palladium-diamine complex. The yield (93%) for the one-step preparation of Diflunisal is the best reported without using a glovebox and a phoshine-based catalyst.
CP-MLR directed QSAR study of carbonic anhydrase inhibitors: sulfonamide and sulfamate inhibitors
Authors: Sharma Brij , Pilania Pradeep , Singh Prithvi , Sharma Susheela , Prabhakar Yenamandra 
Published: October 2009

Abstract
The inhibition activities of sulfonamide and sulfamate derivatives for human carbonic anhydrases have been quantitatively analyzed using DRAGON descriptors. QSAR models have been obtained through combinatorial protocol-multiple linear regression (CP-MLR) computational procedure. For the hCA I inhibition activity, a higher value of information content index of the 1-order neighborhood symmetry (IC1) and a lower value of the Moran autocorrelations, MATS2v and MATS1p, along with a lower number of sulfur atoms in a molecular structure (nRSR) is beneficial to the activity. A higher number of 5-membered rings (nR05), a bigger distance between nitrogen and sulfur T(N..S), and a higher value of van der Waals volume weighted descriptor (GATS6v), are helpful to improve the hCA II inhibition activity. For the inhibition of hpCA, a lower value of the descriptors Jhetv and PW5, and higher values of the eigenvalue sum from Z weighted distance matrix, SEigZ, the Moran autocorrelation of lag 8 weighted by atomic van der Waals volumes, MATS8v and the Moran autocorrelation of lag 4 weighted by atomic Sanderson electronegativities, MATS4e are favorable. The derived significant models in such descriptors may further be used to synthesize new potential compounds and to decipher the mode of their actions at molecular level.