bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanisms responsible for the altered pharmacokinetics of Bosentan: analysis utilizing rats with bile duct ligation‐induced liver dysfunction
Authors: Horiuchi Isao , Mori Yun‐i , Taguchi Masato , Ichida Fukiko , Miyawaki Toshio , Hashimoto Yukiya 
Published: July 2009

AbstractThe purpose of this study was to evaluate the mechanisms responsible for the pharmacokinetic variability of bosentan utilizing rats with liver dysfunction induced by 7‐day bile duct ligation (BDL). Bosentan was administered intravenously at a constant infusion rate (I) of 24, 40 or 60 µg/min/kg. The blood bosentan concentration (BBC) following infusion was measured by HPLC, and apparent clearance (CL) of the drug was estimated asI/BBC. TheCLvalues in normal rats were 30.5 and 19.3 ml/min/kg at infusion rates of 24 and 60 µg/min/kg, respectively, suggesting non‐linear pharmacokinetics of bosentan. TheBBCin BDL rats was much higher than that in normal rats, and theCLvalues in BDL rats were 3.80 and 3.08 ml/min/kg at infusion rates of 24 and 60 µg/min/kg, respectively. TheCLvalue of bosentan at an infusion rate of 40 µg/min/kg in normal rats was decreased significantly by the coadministration of taurocholic acid or bilirubin. In addition, the hepatic mRNA expression of CYP2C6, CYP3A2, Oatp1a1, Oatp1a4 and Oatp1b2 in BDL rats decreased to 77.6%, 34.0%, 65.4%, 84.8% and 44.2% of that in normal rats, respectively. These results suggested that bile acids and/or bilirubin accumulated in BDL rat plasma inhibited the hepatic uptake of bosentan, and that the decreased bosentan clearance in BDL rats was caused at least partly by the impaired expression of hepatic drug‐metabolizing enzymes and uptake transporters. Moreover, because the pharmacokinetics of bosentan was non‐linear at the tested doses, the increasedBBCin BDL rats might further induce the saturation of hepatic uptake and/or metabolism of bosentan. Copyright © 2009 John Wiley & Sons, Ltd.
Genomic mutation rates: what high‐throughput methods can tell us
Authors: Nishant Koodali T. , Singh Nadia D. , Alani Eric 
Published: July 2009

AbstractHigh‐throughput DNA analyses are increasingly being used to detect rare mutations in moderately sized genomes. These methods have yielded genome mutation rates that are markedly higher than those obtained using pre‐genomic strategies. Recent work in a variety of organisms has shown that mutation rate is strongly affected by sequence context and genome position. These observations suggest that high‐throughput DNA analyses will ultimately allow researchers to identify trans‐acting factors and cis sequences that underlie mutation rate variation. Such work should provide insights on how mutation rate variability can impact genome organization and disease progression.
Characterisation of normal and cancer stem cells: One experimental paradigm for two kinds of stem cells
Authors: Mayol Jean‐François , Loeuillet Corinne , Hérodin Francis , Wion Didier 
Published: July 2009

AbstractThe characterisation of normal stem cells and cancer stem cells uses the same paradigm. These cells are isolated by a fluorescence‐activated cell sorting step and their stemness is assayed following implantation into animals. However, differences exist between these two kinds of stem cells. Therefore, the translation of the experimental procedures used for normal stem cell isolation into the research field of cancer stem cells is a potential source of artefacts. In addition, normal stem cell therapy has the objective of regenerating a tissue, while cancer stem cell‐centred therapy seeks the destruction of the cancer tissue. Taking these differences into account is critical for anticipating problems that might arise in cancer stem cell‐centred therapy and for upgrading the cancer stem cell paradigm accordingly.
Incomplete penetrance and variable expressivity: is there a microRNA connection?
Authors: Ahluwalia Jasmine K. , Hariharan Manoj , Bargaje Rhishikesh , Pillai Beena , Brahmachari Vani 
Published: July 2009

AbstractIncomplete penetrance and variable expressivity are non‐Mendelian phenomena resulting in the lack of correlation between genotype and phenotype. Not withstanding the diversity in mechanisms, differential expression of homologous alleles within cells manifests as variations in penetrance and expressivity of mutations between individuals of the same genotype. These phenomena are seen most often in dominantly inherited diseases, implying that they are sensitive to concentration of the gene product. In this framework and the advances in understanding the role of microRNA (miRNA) in fine‐tuning gene expression at translational level, we propose miRNA‐mediated regulation as a mechanism for incomplete penetrance and variable expressivity. The presence of miRNA binding sites at 3′ UTR, co‐expression of target gene–miRNA pairs for genes showing incomplete penetrance and variable expressivity derived from available data lend support to our hypothesis. Single nucleotide polymorphisms in the miRNA target site facilitate the implied differential targeting of the transcripts from homologous alleles.
Electron microscopy of helical filaments: rediscovering buried treasures in negative stain
Authors: Egelman Edward H. , Amos Linda A. 
Published: July 2009

AbstractAlthough negative stain electron microscopy is a wonderfully simple way of directly visualizing protein complexes and other biological macromolecules, the images are not really comparable to those of objects seen in everyday life. The failure to appreciate this has recently led to an incorrect interpretation of RecA‐family filament structures.
Diverse modes of 5′‐[4‐(aminoiminomethyl)phenyl]‐[2,2′‐bifuran]‐5‐carboximidamide (DB832) interaction with multi‐stranded DNA structures
Authors: Kaluzhny Dmitry N. , Borisova Olga F. , Shchyolkina Anna K. 
Published: July 2009

AbstractThe modes of binding of 5′‐[4‐(aminoiminomethyl)phenyl]‐[2,2′‐Bifuran]‐5‐carboximidamide (DB832) to multi‐stranded DNAs: human telomere quadruplex, monomolecular R‐triplex, pyr/pur/pyr triplex consisting of 12 T*(T·A) triplets, and DNA double helical hairpin were studied. The optical adsorption of the ligand was used for monitoring the binding and for determination of the association constants and the numbers of binding sites. CD spectra of DB832 complexes with the oligonucleotides and the data on the energy transfer from DNA bases to the bound DB832 assisted in elucidating the binding modes. The affinity of DB832 to the studied multi‐stranded DNAs was found to be greater (Kass ≈ 107M−1) than to the duplex DNA (Kass ≈ 2 × 105M−1). A considerable stabilizing effect of DB832 binding on R‐triplex conformation was detected. The nature of the ligand tight binding differed for the studied multi‐stranded DNA depending on their specific conformational features: recombination‐type R‐triplex demonstrated the highest affinity for DB832 groove binding, while pyr/pur/pyr TTA triplex favored DB832 intercalation at the end stacking contacts and the human telomere quadruplex d[AG3(T2AG3)3] accommodated the ligand in a capping mode. Additionally, the pyr/pur/pyr TTA triplex and d[AG3(T2AG3)3] quadruplex bound DB832 into their grooves, though with a markedly lesser affinity. DB832 may be useful for discrimination of the multi‐sranded DNA conformations and for R‐triplex stabilization. © 2009 Wiley Periodicals, Inc. Biopolymers 93: 8–20, 2010.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Simultaneous determination of β2‐agonists in human urine by fast‐gas chromatography/mass spectrometry: method validation and clinical application
Authors: Di Corcia Daniele , Morra Veronica , Pazzi Marco , Vincenti Marco 
Published: July 2009

AbstractA fast screening protocol was developed and validated for the simultaneous determination of 15 β2‐agonists in human urine (bambuterol, cimbuterol, clenbuterol, fenoterol, formoterol, isoproterenol, mapenterol, metaproterenol, procaterol, ractopamine, ritodrine, salbutamol, salmeterol, terbutaline, tulobuterol). The overall sample processing includes deconjugation with enzyme hydrolysis, liquid–liquid extraction, followed by derivatization of the extract and detection of β2‐agonists trimethylsilyl‐derivatives by fast‐gas chromatography/electron impact–mass spectrometry (fast‐GC/EI‐MS). Sample extraction and derivatization were optimized with the purpose of improving recoveries and reaction yields for a variety of analytes with different structures simultaneously, while keeping the procedure simple and reliable. Validation parameters were determined for each analyte under investigation, including selectivity, linearity, intra‐ and inter‐assay precision, extraction recoveries and signal to noise ratio (S/N) at the lowest calibration level. Fast‐GC/MS sequences, based on the use of short columns, high carrier‐gas velocity and fast temperature ramping, allow considerable reduction of the analysis time (7 min), while maintaining adequate chromatographic resolution. The overall GC cycle time was less than 9 min, allowing a processing rate of 6 samples/h. High MS‐sampling rate, using a benchtop quadrupole mass analyzer, resulted in accurate peak shape definition under both scan and selected ion monitoring modes, and high sensitivity in the latter mode. The method was successfully tested on real samples arising from clinical treatments. Copyright © 2009 John Wiley & Sons, Ltd.
Fetal topohistology of the mesocolon transversum with special reference to fusion with other mesenteries and fasciae
Authors: Jeong Yeon Jun , Cho Baik Hwan , Kinugasa Yusuke , Song Chang Ho , Hirai Ichiro , Kimura Wataru , Fujimiya Mineko , Murakami Gen 
Published: July 2009

AbstractThe developing mesocolon transversum was investigated using hematoxylin and eosin‐stained semiserial sections derived from 17 human fetuses between 12 and 30 weeks of gestation. The mesocolon was attached to the mesoduodenum and greater omentum until 12 weeks. However, the fetal duodenal attachment appeared not to correspond to the right colic flexure in adults. The greater omentum and mesocolon were likely to be irregularly folded at the attachment site possibly because the developing transverse colon “ran into” and pushed up the greater omentum and pancreatic head. Lymphatic vessels invaded the indistinct fusion plane to destroy the primary configuration. Moreover, the mesocolon seemed to “seize” or take‐over some parts of the splenic side of the greater omentum, but the thick gastric side containing the right gastroepiploic artery and vein remained along the greater curvature. Until 20 weeks, the left colic flexure was fixed to the pancreatic tail, and near the flexure the mesocolon also fused with the renal fascia. The left splenic end of the greater omentum was folded and fused together to form a thick ligament‐like structure, i.e., the gastrocolic ligament. In addition, near the duodenojejunal junction, a peritoneal bridge was often seen containing the inferior mesenteric artery or vein. Although surgeons generally believe that the mesocolon can be gently detached from the greater omentum, the fusion plane in adults appears to be the result of secondary modification and simplification by vascular development. Clin. Anat. 22:716–729, 2009. © 2009 Wiley‐Liss, Inc.
ChemInform Abstract: The Chemical Stability and Conductivity of BaCe0.9‐xYxSn0.1O3‐ δ Solid Proton Conductor for SOFC.
Authors: Xie Kui , Yan Ruiqiang , Liu Xingqin 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Structure and Charge Transport Properties of Yb5Al2Sb6: A Zintl Phase with Incomplete Electron Transfer.
Authors: Todorov Iliya , Chung Duck Young , Ye Linhui , Freeman Arthur J. , Kanatzidis Mercouri G. 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Catalytic atropo‐Enantioselective Preparation of Axially Chiral Biaryl Compounds.
Authors: Ashizawa Tomoko , Yamada Tohru 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Convenient Synthesis of Chlorohydrins from Epoxides Using Zinc Oxide: Application to 5,6‐Epoxysitosterol (X).
Authors: Moghaddam Firouz Matloubi , Saeidian Hamdollah , Mirjafary Zohreh , Javan Marjan Jebeli , Farimani Mehdi Moridi , Seirafi Marjan 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Efficient and Chemoselective Acetalization of Carbonyl Compounds Catalyzed by New and Reusable Zirconyl Triflate, ZrO(OTf)2.
Authors: Moghadam Majid , Mohammadpoor‐Baltork Iraj , Tangestaninejad Shahram , Mirkhani Valiollah , Yazdani Parvin , Ghorjipoor Saeedeh 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Conjugate Addition of 1‐Bromonitroalkanes to α,β‐Unsaturated Aldehydes Catalyzed by Chiral Secondary Amines.
Authors: Zhang Jun‐min , Hu Zhi‐peng , Dong Li‐ting , Xuan Yi‐ning , Lou Chun‐Liang , Yan Ming 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Iron‐Catalyzed Carbolithiation of Alkynes Having no Heteroatoms.
Authors: Shirakawa Eiji , Ikeda Daiji , Ozawa Tsubasa , Watanabe Shogo , Hayashi Tamio 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Highly α‐Regioselective In(OTf)3‐Catalyzed N‐Nucleophilic Substitution of Cyclic Baylis—Hillman Adducts with Aromatic Amines.
Authors: Liu Yu‐Liang , Liu Li , Wang Dong , Chen Yong‐Jun 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reaction of Allylic Phosphoranes with Iron Porphyrin Carbenoids: Efficient, Selective, and Catalytic Intermolecular Formal Carbenoid Insertion into Olefinic C—H Bonds.
Authors: Wang Sunewang R. , Zhu Chun‐Yin , Sun Xiu‐Li , Tang Yong 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Desymmetrization of meso‐N‐Acylaziridines with Benzenethiols Promoted by α,α‐Diaryl‐L‐prolinols.
Authors: Lattanzi Alessandra , Della Sala Giorgio 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Complete Regio‐ and Stereoselectivity Control in the Halohydroxylation of Non‐Activated Allenes Mediated by a Remote Sulfinyl Group.
Authors: Garcia Ruano Jose Luis , Marcos Vanesa , Aleman Jose 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Chiral Schiff Bases Derived from (+)‐ and (‐)‐α‐Pinenes in the Metal Complex Catalyzed Asymmetric Oxidation of Sulfides.
Authors: Koneva E. A. , Volcho K. P. , Korchagina D. V. , Komarova N. I. , Kochnev A. I. , Salakhutdinov N. F. , Tolstikov A. G. 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chiral Broensted Acid Catalyzed Enantioselective α‐Hydroxylation of β‐Dicarbonyl Compounds.
Authors: Lu Min , Zhu Di , Lu Yunpeng , Zeng Xiaofei , Tan Bin , Xu Zhenjiang , Zhong Guofu 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Regioselective Synthesis of Benz[a]anthracene Derivatives via a Pd‐Catalyzed Tandem C—H Activation/Biscyclization Reaction.
Authors: Ren Zhi‐Hui , Guan Zheng‐Hui , Liang Yong‐Min 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Simple and Efficient Oxidation Procedure for the Synthesis of Acid‐Sensitive Epoxides.
Authors: Bortolini Olga , Fantin Giancarlo , Fogagnolo Marco 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: One‐Pot [1 + 1 + 1] Synthesis of Dithieno[2,3‐b:3′,2′‐d]thiophene (DTT) and Their Functionalized Derivatives for Organic Thin‐Film Transistors.
Authors: Chen Ming‐Chou , et al. et al. 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Direct Approach to Multi‐Substituted Pyrroles from 2‐Propynylamine and 1,3‐Diketone or β‐Keto Ester Using Bi(OTf)3 Catalyst.
Authors: Komeyama Kimihiro , Miyagi Motoyoshi , Takaki Ken 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Formation of 1,2‐Dioxolanes Using Mn(III)‐Based Reaction of Various Arylacetylenes with 2,4‐Pentanedione and Related Reaction.
Authors: Tsubusaki Takuma , Nishino Hiroshi 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Simple and Quick Preparation of α‐Thiocyanate Ketones in Hydroalcoholic Media. Access to 5‐Aryl‐2‐imino‐1,3‐oxathiolanes.
Authors: Bisogno Fabricio R. , Cuetos Anibal , Lavandera Ivan , Gotor Vicente 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Microwave‐Assisted Synthesis of Some 2,4‐Thiazolidinedione Derivatives.
Authors: Mahalle Shital , Ligampalle Dinesh , Mane Ramrao 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Copper Nanoparticles in Click Chemistry: An Alternative Catalytic System for the Cycloaddition of Terminal Alkynes and Azides.
Authors: Alonso Francisco , Moglie Yanina , Radivoy Gabriel , Yus Miguel 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Evaluation of Benzophenone Oximes Derivatized with Sydnone as Inhibitors of Secretory Phospholipase A2 with Antiinflammatory Activity.
Authors: Kamble Ravindra Ramappa , Belgur Sudha Sathyanarayanrao , Aladkatti Ravindranath , Khazi Imthiyaz Ahmed 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Fully Substituted Pyrano[2,3‐c]pyrazole Derivatives via a Multicomponent Reaction of Isocyanides.
Authors: Shaabani Ahmad , Sarvary Afshin , Rezayan Ali Hossein , Keshipour Sajjad 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.