bluuebunny/crossref_metadata_2025_split huggingface dataset:
How UN peacekeeping missions enforce peace agreements
Authors: Mailhot Cameron 
Published: April 2024

AbstractHow do UN peacekeeping missions enforce peace agreements, and what effect do higher rates of enforcement have on agreement implementation and conflict termination? Peace agreement enforcement forms a central component of peacekeeping effectiveness, yet missions are often mandated to enforce a minority of agreement provisions, and they vary across both time and space in the ways in which they do so. I identify the three dimensions along which enforcement operates—the proportion and type of provisions that missions are mandated to enforce, alongside their mandated level of involvement in their implementation—and theorize about their positive effects on agreement implementation and conflict termination. Analyzing the Peacekeeping Enforcement Dataset, an original data set of the enforcement patterns of all UN peacekeeping missions (1989–2015), I find that each dimension of enforcement has, at various time points, a distinct impact on agreement implementation and preventing conflict recidivism.
Cassia angustifolia and tacrolimus interaction in a liver transplant patient, a case report
Authors: Beltrá‐Picó Iván , Díaz‐González Marcos , Nalda‐Molina Ricardo , Ramon‐Lopez Amelia , Pascual‐Bartolomé Sonia , Miralles‐Macià Cayetano F. , Rodríguez‐Soler María , Más‐Serrano Patricio 
Published: April 2024

Cassia angustifolia is a species of plant from the Senna family that has traditionally been used as a laxative in different herbal products and commercial medicines. Even though there are few documented drug–plant interactions, the use of C. angustifolia with different drugs may have additive effects, such as with other laxatives or potassium‐depleting diuretics. Its use also increases peristalsis which, may reduce drug absorption. The combination with digoxin has been associated with an increased risk of digoxin toxicity, probably due to an increase in plasma digoxin concentrations and hypokalaemia. We present a case with supratherapeutic trough concentration of tacrolimus, an immunosuppressive agent, and a herbal product in a liver transplant patient after concomitant intake of tacrolimus and a herbal product based on C. angustifolia, suggesting a possible drug–lant interaction through by P‐glycoprotein. We observed an increase in the patient’s blood concentration 2.8‐fold and the area under the curve at steady state 2.1‐fold. This interaction could be of clinical relevance, given the dose‐dependent side effects of tacrolimus, such as nephrotoxicity, neurotoxicity, hypertension, hyperglycaemia, or electrolyte alterations.
On subjective measures of decision quality
Authors: Debrabander Jasper 
Published: April 2024

AbstractIn times of person‐centered care, it is all the more important to support patients in making good decisions about their care. One way to offer such support to patients is by way of Patient Decision Aids (PDAs). Ranging from patient brochures to web‐based tools, PDAs explicitly state the decisions patients face, inform them about their medical options, help them to clarify and discuss their values, and ultimately make a decision. However, lingering discussions surround effectiveness research on PDAs. In this article, I focus on two subjective measures of decision quality that are widely used as outcome measures in effectiveness research on PDAs (i.e., the Decisional Conflict Scale (DCS) and measures of regret). Although these measurement instruments have attracted critical attention in the scientific literature, bioethicists have hardly engaged with them. Therefore, I set myself to analyze the relationship between (the different subscales of) the DCS and measures of regret, on the one hand, and ethical principles such as beneficence and autonomy, on the other hand. In light of that analysis, I will clarify some discussions regarding the use of these measures of decision quality in effectiveness research on PDAs. This should help us to align the way we evaluate PDAs with ethical principles and avoid that our attempts to support patients in making good decisions about their care that is so central to person‐centered care point in unethical directions.
Prognostic impact of genetic abnormalities in 536 first‐line chronic lymphocytic leukaemia patients without 17p deletion treated with chemoimmunotherapy in two prospective trials: Focus on IGHV‐mutated subgroups (a FILO study)
Authors: Nguyen‐Khac Florence , Baron Marine , Guièze Romain , Feugier Pierre , Fayault Alexandra , Raynaud Sophie , Troussard Xavier , Droin Nathalie , Damm Frederik , Smagghe Luce , Susin Santos , Leblond Véronique , Dartigeas Caroline , Van den Neste Eric , Leprêtre Stéphane , Bernard Olivier A. , Roos‐Weil Damien ,   on behalf the FILO (French Innovative Leukaemia Organization) Group
Published: April 2024

SummaryThe potential prognostic influence of genetic aberrations on chronic lymphocytic leukaemia (CLL) can vary based on various factors, such as the immunoglobulin heavy variable (IGHV) status. We conducted an integrative analysis on genetic abnormalities identified through cytogenetics and targeted next‐generation sequencing in 536 CLL patients receiving first‐line chemo(immuno)therapies (CIT) as part of two prospective trials. We evaluated the prognostic implications of the main abnormalities, with specific attention to their relative impact according to IGHV status. In the entire cohort, unmutated (UM)‐IGHV, complex karyotype, del(11q) and ATM mutations correlated significantly with shorter progression‐free survival (PFS). Focusing on the subset of mutated IGHV (M‐IGHV) patients, univariate analysis showed that complex karyotype, del(11q), SF3B1 and SAMHD1 mutations were associated with significant lower PFS. The prognostic influence varied based on the patient's IGHV status, as these abnormalities did not affect outcomes in the UM‐IGHV subgroup. TP53 mutations had no significant impact on outcomes in the M‐IGHV subgroup. Our findings highlight the diverse prognostic influence of genetic aberrations depending on the IGHV status in symptomatic CLL patients receiving first‐line CIT. The prognosis of gene mutations and cytogenetic abnormalities needs to be investigated with a compartmentalized methodology, taking into account the IGVH status of patients receiving first‐line BTK and/or BCL2 inhibitors.
On the Dialectical Dialogue in Supervision
Authors: Yerushalmi Hanoch 
Published: April 2024

AbstractWhereas the therapeutic action centres on emotional participation and containment of the patient's intolerable experiences, the supervisory action centres on interpreting the reconstructed therapeutic reality. Since the emergent interpretation is subjective and contextual, it requires processing in a dialogue between the supervisor and the supervisee. However, their existential need to define and assert themselves as professionals often urges them to highlight the differences between their perceptions and beliefs and keenly convince each other. Uncontained, this dialectical tension might disrupt the supervisory process and the participants' well‐being. Despite the existential urges, when the supervisor and the supervisee recognize and validate each other as independent and autonomous professionals, they can restrain their competitiveness, maintain a productive dialectical dialogue, achieve creative and integrated understandings of the therapeutic process and consolidate their professional identities. Moreover, despite the hierarchical supervisory relationship, acknowledging their vulnerability helps supervisors recognize and validate their supervisees and facilitate the dialectical supervisory dialogue.
Child and Family Social Work as a Space for Promoting Social Cohesion
Authors: Dierckx Melissa , Vandenbroeck Michel , Devlieghere Jochen 
Published: April 2024

ABSTRACTPromoting social cohesion is frequently mentioned as an objective for child and family social work from a policy perspective. However, it is unclear how policies shape concrete child and family social work practices. The aim of the current study is to analyse how early childhood services in Flanders (Belgium) commit to the promotion social cohesion. An explorative multiple case study in Flanders, using (non)participatory observations (N = 40), was performed in child and family social work practices to answer the following research question: What is going on in child and family social work regarding the promotion of social cohesion? The research indicates that in the context of child and family social work, it is important to pay attention to the meaning of these light encounters as a possible way to foster social cohesion. Given the importance of light encounters in child and family social work, a reflection on the role of the infrastructure should be made. To end, a clear need and challenge became visible regarding the diversity in child and family social work practices. It is necessary to reach a diversity of families, but this implies that practitioners have the knowledge and know‐how in approaching and dealing with diversity issues.
Forming Evaluations of Moral Character: How Are Multiple Pieces of Information Prioritized and Integrated?
Authors: Landy Justin F. , Perry Alexander D. 
Published: April 2024

AbstractEvaluating other people's moral character is a crucial social cognitive task. However, the cognitive processes by which people seek out, prioritize, and integrate multiple pieces of character‐relevant information have not been studied empirically. The first aim of this research was to examine which character traits are considered most important when forming an impression of a person's overall moral character. The second aim was to understand how differing levels of trait expression affect overall character judgments. Four preregistered studies and one supplemental study (total N = 720), using five different measures of importance and sampling undergraduates, online workers, and community members, found that our participants placed the most importance on the traits honest, helpful, compassionate, loyal, and responsible. Also, when integrating the information that they have learned, our participants seemed to engage in a simple averaging process in which all available, relevant information is combined in a linear fashion to form an overall evaluation of moral character. This research provides new insights into the cognitive processes by which evaluations of moral character are formed.
Unusual isolated cytomegalovirus cutaneous infections: A subtle histopathologic diagnosis with review of the literature
Authors: Hartsough Emily M. , Nazarian Rosalynn M. , Cornejo Kristine M. , Stagner Anna M. 
Published: April 2024

AbstractCytomegalovirus (CMV) infection is common and often self‐limited. Reactivation results in a variety of disease presentations, especially in the setting of immunocompromise. While cutaneous manifestations of systemic CMV infection are rare, dermatologic manifestations of CMV are increasingly reported with a wide morphologic spectrum clinically. Three male patients, with untreated human immunodeficiency virus (HIV), penile lichenoid dermatitis treated with long‐term topical and intralesional corticosteroids, and metastatic Merkel cell carcinoma on immune checkpoint inhibitor therapy, each presented with isolated cutaneous ulcers. The ulcers were located on the perianal skin, glans of the penis, and distal thumb. In each case, nonspecific histopathologic features were seen. However, very rare dermal cytomegalic cells with nuclear and cytoplasmic inclusions were present and highlighted with an immunohistochemical stain for CMV. Isolated ulcers due to CMV infection may occur in the setting of systemic or localized immunosuppression. A high index of suspicion is needed upon histopathologic evaluation, as few cytomegalic cells may be present and accurate diagnosis is crucial for prompt and appropriate clinical management.
Mental health profiles of depressive symptoms and personal well‐being among active‐duty military families
Authors: O'Neal Catherine Walker , Lavner Justin A. , Jensen Todd M. , Lucier‐Greer Mallory 
Published: April 2024

AbstractAlthough some research has examined the mental health of individual family members in military families, additional research is needed that considers mental health among multiple members of the family system simultaneously and that characterizes subsets of families with distinct patterns. Mental health patterns of depressive symptoms and well‐being in and among families were identified using latent profile analysis with a community sample of 236 military families with a service member (SM) parent, civilian partner, and adolescent. Drawing from the Family Adjustment and Adaptation Response model, we examined several military‐related family demands (e.g., relocations, deployments) and capabilities (e.g., family cohesion, social support outside the family) as correlates of the family profiles. Three profiles emerged: thriving families (62.3% of the sample where all three family members reported relatively low depressive symptoms and high personal well‐being), families with a relatively distressed SM (24.2%), and families with a relatively distressed adolescent (13.5%). Overall, there were no differences between the groups of families regarding military‐related demands, yet there were differences between the groups regarding their capabilities, namely family cohesion and social support. In general, families in the thriving profile tended to have higher family cohesion and social support as reported by multiple family members compared to the other two profiles. Findings can inform the development of family needs assessments and tailored interventions (and intervention points) based on family profiles and current capabilities.
Neotropical mammal responses to megafires in the Brazilian Pantanal
Authors: Bardales Rocío , Boron Valeria , Passos Viana Diego Francis , Sousa Lara L. , Dröge Egil , Porfirio Grasiela , Jaramillo Maricruz , Payán Esteban , Sillero‐Zubiri Claudio , Hyde Matthew 
Published: April 2024

AbstractThe increasing frequency and severity of human‐caused fires likely have deleterious effects on species distribution and persistence. In 2020, megafires in the Brazilian Pantanal burned 43% of the biome's unburned area and resulted in mass mortality of wildlife. We investigated changes in habitat use or occupancy for an assemblage of eight mammal species in Serra do Amolar, Brazil, following the 2020 fires using a pre‐ and post‐fire camera trap dataset. Additionally, we estimated the density for two naturally marked species, jaguars Panthera onca and ocelots Leopardus pardalis. Of the eight species, six (ocelots, collared peccaries Dicotyles tajacu, giant armadillos Priodontes maximus, Azara's agouti Dasyprocta azarae, red brocket deer Mazama americana, and tapirs Tapirus terrestris) had declining occupancy following fires, and one had stable habitat use (pumas Puma concolor). Giant armadillo experienced the most precipitous decline in occupancy from 0.431 ± 0.171 to 0.077 ± 0.044 after the fires. Jaguars were the only species with increasing habitat use, from 0.393 ± 0.127 to 0.753 ± 0.085. Jaguar density remained stable across years (2.8 ± 1.3, 3.7 ± 1.3, 2.6 ± 0.85/100 km2), while ocelot density increased from 13.9 ± 3.2 to 16.1 ± 5.2/100 km2. However, the low number of both jaguars and ocelots recaptured after the fire period suggests that immigration may have sustained the population. Our results indicate that the megafires will have significant consequences for species occupancy and fitness in fire‐affected areas. The scale of megafires may inhibit successful recolonization, thus wider studies are needed to investigate population trends.
Transect walks and malaise traps differ in temperature sensitivity but reveal consistent drivers of pollinator richness
Authors: Kerner Janika M. , König Sebastian , Maihoff Fabienne , Bofinger Lukas , Sauer Nikki , Ssymank Axel , Väth Peter , Classen Alice 
Published: April 2024

Abstract
While transect walks have long been the preferred monitoring method for many flying insect taxa, malaise traps combined with DNA metabarcoding have gained growing prominence. However, it remains unclear whether both methods reveal comparable species richness and the same ecological drivers along environmental gradients.
We selected three groups of pollinators (wild bees, hoverflies and butterflies) and one group of herbivores (grasshoppers) as functionally important and conservation‐relevant model groups, comparing results of both methods along an elevational gradient in the German Alps.
Across the study region, both methods detected a similarly high species richness of pollinators with ~50% overlap of species pools, but transect walks revealed more species per site, especially in higher elevations and under low temperatures. Body size spectra differed between methods, with on average more large butterfly and more small bee species in transect walks. Nevertheless, temperature and flower richness were consistent drivers of pollinator richness, independent of the sampling method. Grasshopper richness from transect walks was considerably higher than from malaise traps. Both methods identified temperature and only malaise traps also identified management as drivers of grasshopper richness.
We conclude that malaise traps are principally suitable substitutes for the more time‐consuming pollinator transect walks. However, the effectiveness of these passive traps is more susceptible to changes in sampling temperature, and in some pollinator groups, body size classes are presented differently, which is important to consider during analyses. For grasshoppers, transect walks appear to be more suitable to assess species richness, as considerably more species can be monitored.
Association between STAT4 gene polymorphism and susceptibility to pulmonary tuberculosis in the Moldavian population
Authors: Varzari Alexander , Tudor Elena , Corloteanu Andrei , Axentii Ecaterina , Vladei Iurie , Deyneko Igor V. 
Published: April 2024

AbstractSignal transducer and activator of transcription 4 (STAT4) plays a crucial role in the host immune response against Mycobacterium tuberculosis. This study investigates the association between STAT4 gene polymorphisms and pulmonary tuberculosis (TB) risk in the Moldavian population. A total of 272 TB patients and 251 community‐matched controls underwent screening for functional single‐nucleotide polymorphisms (SNPs) rs897200 and rs7574865 in the STAT4 gene. The minor T allele and the TT/CT genotype of rs897200 demonstrated a significant association with reduced pulmonary TB risk (allelic model: adjusted OR = .74, p = .025; log‐additive model: adjusted OR = .72, p = .02; and dominant model: adjusted OR = .65, p = .023), indicating a protective effect. Similar associations, characterized by an even more pronounced reduction in risk, were observed among females and late‐onset TB patients (>44 years). No significant associations were found for rs7574865. In addition, a combined genotype analysis incorporating 43 SNPs from our previous studies revealed potential associations, such as STAT4 rs897200 CT with IFNG rs2430561 AA (adjusted OR = .36, p = .0025) and STAT4 rs897200 CT with TNFA rs1800629 GA (adjusted OR = .33, p = .0012). This study emphasizes the significant association of STAT4 rs897200 with pulmonary TB risk in the Moldavian population, underscoring its role in the disease development.
Indications and outcomes of transjugular intrahepatic portosystemic shunt insertion in two regional Australian hepatology centres
Authors: Commins Natalie , Subhaharan Deloshaan , Kurup Rajiv , Wickremeratne Tehara , Mitchell Jonathan , Elmes Julie , Braund Alicia , Funakoshi Natalie , Langton Jonathan , Leschke Paul , O'Beirne James 
Published: April 2024

ABSTRACTBackgroundTransjugular intrahepatic portosystemic shunt (TIPS) is an important therapy for complications of portal hypertension but remains underutilised in regional settings.AimsThe aim of this study is to explore the demographics, indications, outcomes and complications in patients undergoing TIPS in two regional hepatology centres.MethodsRetrospective analysis was undertaken of all patients undergoing TIPS at two regional centres between January 2017 and March 2023. The primary outcome measures were efficacy and complications of TIPS. Patient demographics (such as age, baseline liver severity scores and aetiology of liver disease) and indications for TIPS are detailed.ResultsForty‐eight patients underwent TIPS. Median age was 56 years (interquartile range (IQR): 46–65). The most common indications for TIPS were refractory ascites (n = 17) and failure of secondary prophylaxis of variceal bleeding (n = 13). Cumulative survival at 3 months and 1 year was 93% and 77% respectively. There was no significant difference in outcomes based on TIPS indication. The median number of paracenteses in patients undergoing TIPS for refractory ascites 1 year pre‐ and post‐TIPS were 10 (IQR: 4.5–16) and 2 (IQR: 0–4) respectively (P < 0.001). There were no procedure‐related deaths. Inpatient management of liver disease complications had a mean cost of $32 874.67 (SEM: 7779) in 1 year pre‐TIPS compared with $12 304.70 (SEM: 3531.1) in 1 year post‐TIPS (P < 0.001).ConclusionsTIPS is a safe and effective treatment to reduce complications of portal hypertension and can be performed successfully in the regional setting.
RETRACTED: Clinical observation of ultraviolet therapy combined with autologous platelet‐rich plasma in the treatment of chronic refractory wounds
Authors: Li Gaoquan , Liu Songtao , Tan Guange , Wang Shanxi , Xie Juying 
Published: April 2024

AbstractRefractory wounds present complex and serious clinical dilemmas in plastic and reconstructive surgeries. Currently, there are no standard guidelines for the treatment of refractory wounds. To observe the clinical effects of ultraviolet (UV) therapy combined with autologous platelet‐rich plasma (PRP) on chronic refractory wounds. Between January 2021 and December 2022, 60 inpatients with chronic refractory wounds were enrolled. Twenty patients were assigned to each of control groups 1 and 2 and treatment group according to whether they received PRP or UV treatment. All the patients underwent thorough debridement. Control group 2 received UV radiation. The treatment group underwent UV radiation combined with PRP gel covering the wound. Control group 1 underwent routine dressing changes after surgery, followed by skin grafting or skin key transfer if needed. One month later, we observed the wound healing in the two groups. After 2—4 PRP gel treatments, the wounds of patients in the treatment group healed. The healing time was 25.25 ± 4.93 days, and the dressings were changed 4.15 ± 3.30 times, both of which were better outcomes than in both control groups. In the treatment group, epidermal growth factor (EGF), insulin‐like growth factor (IGF), platelet‐derived growth factor (PGF), and transforming growth factor β (TGF‐β) were slightly higher, and the concentration of vascular endothelial growth factor (VEGF) was significantly higher than in the control group (p < 0.05). PRP combined with UV therapy significantly increased the concentration of wound growth factors, accelerated wound healing, shortened treatment time, reduced treatment costs, and alleviated pain in patients.