bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative detection of the new polyomaviruses KI, WU and Merkel cell virus in transbronchial biopsies from lung transplant recipients: Table 1
Authors: Bergallo Massimiliano , Costa Cristina , Terlizzi Maria Elena , Astegiano Sara , Curtoni Antonio , Solidoro Paolo , Delsedime Luisa , Cavallo Rossana 
Published: July 2010

BackgroundRecently, three new polyomaviruses—KI, WU and Merkel cell (MCV)—have been discovered and their detection has been reported in different types of specimens, including respiratory samples, suggesting their shedding in the airways. In lung graft recipients, viral agents are associated with events that may limit the success of transplantation, including organ infection/disease and allograft rejection.AimsTo evaluate the prevalence of KI, WU and MCV in transbronchial biopsies from lung transplant recipients and investigate the association with clinical and histopathological features.MethodsThe quantitation of new polyomaviruses DNA by real-time PCR and association with clinical and histopathological findings were evaluated in 66 transbronchial biopsies from lung transplant recipients.ResultsKI, WU and MCV were detected in 9.2%, 12.3% and 33.8% of specimens, respectively; with mean viral load ranging from 81 copies/104cells for WU to 258 for MCV, thus not differing from that previously reported in native lungs. No significant association with clinical and histopathological findings (including acute respiratory insufficiency, interstitial and organising pneumonia, acute and chronic rejection) was found.ConclusionsResults showed a relatively high frequency of detection of the novel polyomaviruses in transbronchial biopsies from lung transplant recipients. It is likely that this accounted for the positive results found in some cases with different pathological background, although no significant association with a specific clinical and/or histopathological pattern was found.
A Seven-Gene Set Associated with Chronic Hypoxia of Prognostic Importance in Hepatocellular Carcinoma
Authors: van Malenstein Hannah , Gevaert Olivier , Libbrecht Louis , Daemen Anneleen , Allemeersch Joke , Nevens Frederik , Van Cutsem Eric , Cassiman David , De Moor Bart , Verslype Chris , van Pelt Jos 
Published: July 2010

AbstractPurpose: Hepatocellular carcinomas (HCC) have an unpredictable clinical course, and molecular classification could provide better insights into prognosis and patient-directed therapy. We hypothesized that in HCC, certain microenvironmental regions exist with a characteristic gene expression related to chronic hypoxia which would induce aggressive behavior.Experimental Design: We determined the gene expression pattern for human HepG2 liver cells under chronic hypoxia by microarray analysis. Differentially expressed genes were selected and their clinical values were assessed. In our hypothesis-driven analysis, we included available independent microarray studies of patients with HCC in one single analysis. Three microarray studies encompassing 272 patients were used as training sets to determine a minimal prognostic gene set, and one recent study of 91 patients was used for validation.Results: Using computational methods, we identified seven genes (out of 3,592 differentially expressed under chronic hypoxia) that showed correlation with poor prognostic indicators in all three training sets (65/139/73 patients) and this was validated in a fourth data set (91 patients). Retrospectively, the seven-gene set was associated with poor survival (hazard ratio, 1.39; P = 0.007) and early recurrence (hazard ratio, 2.92; P = 0.007) in 135 patients. Moreover, using a hypoxia score based on this seven-gene set, we found that patients with a score of &gt;0.35 (n = 42) had a median survival of 307 days, whereas patients with a score of ≤0.35 (n = 93) had a median survival of 1,602 days (P = 0.005).Conclusions: We identified a unique, liver-specific, seven-gene signature associated with chronic hypoxia that correlates with poor prognosis in HCCs. Clin Cancer Res; 16(16); 4278–88. ©2010 AACR.
Ecological Studies On Carabid Beetles
Authors: Richter C.J.J. , Hartsuijker L. , Vlijm L. 
Published: July 2010

AbstractWith the aid of a trapping techniques with tins (one tin to the square meter) carabid beetles were collected at Schiermonnikoog, one of the Wadden-islands, in 1958, 1959 and 1960. Calathus melanocephalus was most active at the beginning of the nocturnal period. The number of animals which were caught in different nights is related to the temperature. The higher temperature in the nocturnal period, the more animals are trapped. The animals in some periods prefer a very dense vegetation as LINDROTH (1945) has remarked; at other times (as LARSSON, 1939, noted), a scarce vegetation. This is most probably related to the amount of rainfall. In dryer periods Calathus melanocephalus prefers dense vegetation, whereas in periods with a good amount of rainfall areas with scarce vegetation are preferred.
Drosophila Andalusiaca, a Polymorphic Species New To Holland
Authors: Beardmore J.A. 
Published: July 2010

AbstractDrosophila andalusiaca, with one qualified exception hitherto unreported from Holland, has been found in various localities including some of the coastal islands. The sex-limited polymorphism for abdomen colour is also found to occur in some populations, the gene frequencies for the two alleles in one population being roughly equal.
De schiet- en loterijprijzen van de Delftse schutters uit 1621 en 1631
Authors: Huys Janssen Paul 
Published: July 2010

AbstractIn the municipal archives in Delft are two unique printed lists that inform us about events organised by the Delft civic guard in 1621 and 1631. In 1621 a shooting contest was being held and the prices were several pieces of silver and a number of paintings. These were mainly by Esaias van de Velde, but there were also works by Bartholomeus van Bassen, Cornelis Jacobsz Delff, Joos de Momper together with Jan Brueghel the Elder, Pieter van Bronckhorst, the unknown Pieter Jacobsz Lupert and two works by Hendrick Gerritsz Pot. In the document he titles of the paintings are given, but it is not possible to trace any of these works. In 1631 the civic guard organised a lottery. A large number of paintings were to be won, mainly by painters from Utrecht. The first prize was a series of the five senses by Gerard van Honthorst, Abraham (or maybe Hendrick ?) Bloemaert, Paulus Moreelse, Jan van Bijlert and Hendrick ter Brugghen. There were also paintings by Roelandt Saverij, Adam Willaerts, Joost Cornelisz Droochsloot and Gijsbert and Gillis Hondecoeter. Prom Delft Leonaert Bramer, Cornelis Jacobsz Delff, Anthonie Palamedesz together with Barthomeus van Bassen, Palamedes Palamedesz and Jacob Vosmaer are represented. Also two paintings by Esaias van de Velde are mentioned. Again the titles are given, but they offer no clues to any present whereabouts. From a notarial act it appears that in 1644 again a shooting contest was being held. Now there were only seven paintings to be won. They were supplied by the still life painter Evert van Aelst, and he undoubtedly painted them. No titles are given. Again in 1647 and 1661 shooting contests were being held. Now the prices were simple pieces of silver. According to this pattern, over the decades the populariry of paintings in Delft was diminishing.
Twee onbekende luiken met stichtersportretten door Aertgen van Leyden
Authors: Ekkart Rudolf E.O. 
Published: July 2010

AbstractIn the Musée des Beaux-Arts at Lille there are two shutters from a North-Netherlandish commemorative painting (fig. 2/3) which on comparison with two others in the museums at Valenciennes (fig. i) and La Fère may be attributed to the painter Aertgen van Leyden. The coats of arms painted on the outsides of the shutters (fig-4/5) identify the sitters as Claes Alewijn Claeszz., burgomaster of Leiden (d. 1561), and his wife Anna Cornelisdr. van der Hooch (d.1558) with their children. The whereabouts of the central panel are unknown, but the work must have been painted for the Pieterskerk in Leiden, where the same couple's tombstone, made by the Frisian carver Pieter Dircksz., still is (fig. 6).
Wolfgang Avemann (I583 - nach I620) und die frühe Verbreitung der niederländischen Architekturmalerei
Authors: Fusenig Thomas 
Published: July 2010

AbstractIt is sometimes difficult to distinguish the work of those Netherlandish painters who left their homeland in the second half of the I6th century, from that of their German pupils and followers from around I600. The genre of architectural painting is a particularly informative example of the complexities involved in this cultural exchange. Some years ago, the Gemäldegalerie Alte Meister, Kassel, acquired a very interesting interior by an almost unknown Hessian painter Wolfgang Avemann (I583- after I620) (fig. I). With this as the starting point, it is possible to reattribute to Avemann a number of perspective paintings (fig. 3, 5-8, I2, 13), which until now were mostly attributed to either Hendrik van Steenwijck the Elder (around I550 - I603) or the Younger (I58I/82-I649). The Van Steenwijck workshop was active at Frankfurt around I600, and since in almost all his paintings Avemann used the Van Steenwijck compositional structure (fig. 2, 4, 9), it is most probable that he was an apprentice in their workshop in Frankfurt. Moreover, his figures were influenced by Frederik and Gillis van Valckenborch (fig. I0), who returned to Frankfurt from Italy just at the time when Avemann was learning his craft. Avemann became a master in Nuremberg in I6I2. Another young master of perspective painting working in the city at the same time was Paul Juvenel (I579-I643) (fig. II), whose father was a Netherlandish émigré. Interestingly, Juvenel's pictures are sometimes mistaken for works by the Van Steenwijcks. Clarifying Avemann's role as a painter of perspective pictures expands not only our understanding of the genre of perspective painting in the early I7th century, but also sheds light on the important influence of Netherlandish artists living in Frankfurt (and Nuremberg) - and just at the time when the young Adam Elsheimer departed for Italy.
Herman van Swanevelt als Radierer. Zur Chronologie der Entwürfe und der Drucke
Authors: Steland Anne Charlotte 
Published: July 2010

AbstractIn the 1630s the Dutch Italianate painter Herman van Swanevelt (ca. 1603-1655) developed in Rome, in collaboration with his colleague and contemporary Claude Lorrain, what in those days was a new type of idyllic ideal landscape whose sunlit 'contrejours' reflected the times of day and which Swanevelt continued to disseminate in the North after he moved to Paris. It was however chiefly his etchings which made this new type of landscape accessible to a large public, and which decisively contributed to the development of the taste for landscape art into the eighteenth century, notably in France. In terms of quality and quantity, Swanevelt was the foremost etcher among the early Italianates. The first of his etchings were made in Rome, probably stimulated by the French etchers Charles Audran, who lived in his house there from 1632 to 1634, and by Claude Lorrain, who made 39 etchings in the 1630s, while most of Swanevelt's - 90 - originated in Paris. The only works he dated are two late series (1653 and 1654). However, during the preparation of Swanevelt's monograph with its critical catalogue of the paintings and drawings, it emerged that the dates of all his authentic, undated designs and prints can be ascertained with a fair degree of accuracy, particularly with the aid of his dated and datable drawings and paintings. Two additional drawings could be established as designs for etchings by Pierre Mariette which were first published after Swanevelt's death, and also four drawings in the Uffizi in Florence, two of them with the visible traces of the etching needle, for four etchings without signature or address. This essay rectifies dates published in A.C. Blume's article of 1994. It makes use of newly found documents, published by M. Szanto in his excellent, substantial article (2003), and facts, published in less accessible literature and providing valuable information pertaining to the biographical background of Swanevelts activity as an etcher during his Paris years. It furthermore combines the familiar signatures, names and addresses of publishers with the critical evaluation of Swanevelt's numerous drawn designs with the nature studies used for this and, for the Paris years, with the new findings in Szanto's monograph. This essay for the first time provides a more exact survey of Swanevelt's development as a draughtsman, the times at which his designs were made and his etchings were printed.
Gender differences in the knowledge, attitude and practice towards mental health illness in a rapidly developing Arab society
Authors: Bener Abdulbari , Ghuloum Suhaila 
Published: July 2010

Background: Mental disorders are common in all countries and cause immense suffering. Both gender and low socioeconomic status have been related to depression and other common mental disorders, but their possible relationship to mental health literacy remains uncertain. Aim: The aim of this study was to determine the gender differences in knowledge, attitudes and practices towards mental illness in a sample of Qatari and other Arab expatriates residing in the State of Qatar. Design: This is a cross-sectional survey. Setting: Primary healthcare centres in the State of Qatar. Subjects: A multi-stage sampling design was used and a representative sample of 3,300 Qatari and other Arab expatriates above 20 years of age were surveyed during the period from October 2008 to June 2009. Of the study sample of 3,300, 2,514 subjects (76.2%) expressed their consent to participate. Methods: A questionnaire was designed to assess the gender difference in knowledge, attitudes and practice towards mental illness.This questionnaire was administered to the Arab adult population above 20 years of age who were attending primary healthcare centres for various reasons other than mental illness. Face-to-face interviews were based on this questionnaire, which included variables on socio-demographic characteristics, knowledge, attitude and practice towards mental illness. Results: Of the study sample, 49.2% were men and 50.8% were women. Overall, the studied women held more to the cultural beliefs related to some aspects of mental illness. For example, more women than men believed that mental illness is due to possession by evil spirits. Also, nearly half of the women thought traditional healers can treat mental illness; this belief was significantly lower in men. Some of the women considered people with mental illness as dangerous; a belief also significantly lower in men. Men had a better attitude towards mental illness than women. Men were more willing to visit a psychiatrist for their emotional problems, while women preferred a traditional healer. Women were more afraid than men to talk to the mentally ill. Knowledge of common mental illnesses was generally poor, and it seemed to be lower among women. Men obtained more information than women from the media; women favoured healthcare staff more than men did. Conclusion: The study reveals that men had better knowledge, beliefs and attitudes towards mental illness than women. Most of the women were afraid and not willing to keep friendships with the mentally ill. The results of this study underline the importance of information in changing people’s attitude towards mental illness. Recognition of common mental disorders was very poor in men and women.
Contact with Birth Parents
Authors: Curtis Reagan , Pearson Frances 
Published: July 2010

• Summary: Adults adopted as infants ( N = 130) in the United States were surveyed to determine the degree to which they experienced psychological effects of adoption during adolescence and adulthood and the relationship between psychological effects and whether or not they had contact with their birth parents. • Findings: Those who were in contact reported more psychological issues than those who were not in contact. A qualitative analysis of comments made by the respondents demonstrated differences in the types of issues associated with difficulties depending upon whether they had contact with their birth parents or not. • Applications : The results are discussed in light of the literature on searching behaviors among adopted individuals.
Understanding Attrition and Predicting Employment Durations of Former Staff in a Public Social Service Organization
Authors: Thaden Emily , Jacobs-Priebe Lynette , Evans Scot 
Published: July 2010

• Summary: This study examines factors related to employee attrition in a US state social service organization (SSSO) that administers welfare, food stamps, and Medicaid. • Findings: Semi-structured telephone interviews were conducted with 132 former SSSO employees. Qualitative analyses found that informants reported insufficient resources to do their jobs, inconsistent or inadequate training experiences, negative perceptions of the organizational culture and management (e.g. minimal recognition and inadequate support for professional growth or innovation), and typically positive perceptions of co-worker relationships during their tenures at the SSSO. To examine the relative impact of these factors and background variables (age, race, office location, and position) on duration of employment, a multiple linear regression was conducted. Age, office location, position, and perceptions of organizational culture significantly predicted duration of employment ( F(7,123) = 24.19, p < .001, R2 = .56). • Application: Findings suggest that organizational culture may be an important change target for retaining workers in SSSOs.
The Millennium Development Goals and tobacco control
Authors: Collishaw Neil E. 
Published: July 2010

The eight Millennium Development Goals were proposed by the UN Secretary-General in 2001. They are goals with measurable targets to be achieved by 2015 or earlier. The Goals were distilled from the 2000 United Nations Millennium Declaration, a sweeping statement of development values, principles, objectives and proposed actions. The Framework Convention on Tobacco Control (FCTC) is a demonstrable translation of some of the ideas in the Millennium Declaration into reality. With 165i Parties, the FCTC does more than just improve global tobacco control: • The FCTC contributes to achievement of many of the Millennium Development Goals, and benefits from success in implementation of the Goals in other sectors. • The treaty itself is a demonstration of strengthened international and national rule of law, central tenets of the Millennium Declaration. • The FCTC expands international law into the health sector and provides better balance of international law among economic, environmental, social and health sectors. The Millennium Declaration calls for a more equitable distribution of the benefits of globalization, and the FCTC delivers this result. • The FCTC provides a model for addressing other unsolved global problems through greater use of international law. Alcohol control and dietary improvements including greater control of empty calories in manufactured foods are examples of problems that may benefit from greater governance by international law. Were that to come to pass, those new treaties would also improve implementation of the Millennium Declaration and the Millennium Development Goals.
Reimplantation of cryopreserved ovarian tissue from patients with acute lymphoblastic leukemia is potentially unsafe
Authors: Dolmans Marie-Madeleine , Marinescu Cristina , Saussoy Pascale , Van Langendonckt Anne , Amorim Christiani , Donnez Jacques 
Published: July 2010

Abstract
Ovarian tissue cryopreservation is currently proposed to young cancer patients to preserve their fertility before radiochemotherapy. The potential risk is that the tissue might harbor malignant cells that could induce disease recurrence. We therefore decided to evaluate the presence of leukemic cells in cryopreserved ovarian tissue from 18 leukemic patients: 6 with chronic myeloid leukemia (CML) and 12 with acute lymphoblastic leukemia (ALL). In each case, histology, quantitative reverse-transcribed polymerase chain reaction (RT-PCR) and long-term (6 months) xenografting to immunodeficient mice were used. Histology did not identify any malignant cells in the ovarian tissue. By quantitative RT-PCR, 2 of 6 CML patients were positive for BCR-ABL in their ovarian tissue. Among the 12 ALL patients, 7 of the 10 with available molecular markers showed positive leukemic markers in their ovarian tissue (translocations or rearrangement genes). Four mice grafted with ovarian tissue from ALL patients developed intraperitoneal leukemic masses. In conclusion, this study demonstrates, by quantitative RT-PCR, ovarian contamination by malignant cells in acute as well as chronic leukemia, whereas histology fails to do so. Moreover, chemotherapy before ovarian cryopreservation does not exclude malignant contamination. Finally, reimplantation of cryopreserved ovarian tissue from ALL and CML patients puts them at risk of disease recurrence.
Improved outcome with hematopoietic stem cell transplantation in a poor prognostic subgroup of infants with mixed-lineage-leukemia (MLL)–rearranged acute lymphoblastic leukemia: results from the Interfant-99 Study
Authors: Mann Georg , Attarbaschi Andishe , Schrappe Martin , De Lorenzo Paola , Peters Christina , Hann Ian , De Rossi Giulio , Felice Maria , Lausen Birgitte , LeBlanc Thierry , Szczepanski Tomasz , Ferster Alina , Janka-Schaub Gritta , Rubnitz Jeffrey , Silverman Lewis B. , Stary Jan , Campbell Myriam , Li Chi Kong , Suppiah Ram , Biondi Andrea , Vora Ajay , Valsecchi Maria Grazia , Pieters Rob ,   on behalf of the Interfant-99 Study Group
Published: July 2010

AbstractTo define a role for hematopoietic stem cell transplantation (HSCT) in infants with acute lymphoblastic leukemia and rearrangements of the mixed-lineage-leukemia gene (MLL+), we compared the outcome of MLL+ patients from trial Interfant-99 who either received chemotherapy only or HSCT. Of 376 patients with a known MLL status in the trial, 297 (79%) were MLL+. Among the 277 of 297 MLL+ patients (93%) in first remission (CR), there appeared to be a significant difference in disease-free survival (adjusted by waiting time to HSCT) between the 37 (13%) who received HSCT and the 240 (87%) who received chemotherapy only (P = .03). However, the advantage was restricted to a subgroup with 2 additional unfavorable prognostic features: age less than 6 months and either poor response to steroids at day 8 or leukocytes more than or equal to 300 g/L. Ninety-seven of 297 MLL+ patients (33%) had such high-risk criteria, with 87 achieving CR. In this group, HSCT was associated with a 64% reduction in the risk of failure resulting from relapse or death in CR (hazard ratio = 0.36, 95% confidence interval, 0.15-0.86). In the remaining patients, there was no advantage for HSCT over chemotherapy only. In summary, HSCT seems to be a valuable option for a subgroup of infant MLL+ acute lymphoblastic leukemia carrying further poor prognostic factors. The trial was registered at www.clinicaltrials.gov as #NCT00015873 and at www.controlled-trials.com as #ISRCTN24251487.