bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic impact of heart failure admission in survivors of acute myocardial infarction
Authors: Takeuchi Satoshi , Honda Satoshi , Nishihira Kensaku , Kojima Sunao , Takegami Misa , Asaumi Yasuhide , Saji Mike , Yamashita Jun , Hibi Kiyoshi , Takahashi Jun , Sakata Yasuhiko , Takayama Morimasa , Sumiyoshi Tetsuya , Ogawa Hisao , Kimura Kazuo , Yasuda Satoshi ,   JAMIR Investigators
Published: April 2024

AbstractAimsThe incidence and prognosis of symptomatic heart failure following acute myocardial infarction (AMI) in the primary percutaneous coronary intervention era have rarely been reported in the literature. This study aimed to (i) determine the incidence of heart failure admission among AMI survivors, (ii) compare 1 year outcomes between patients with heart failure admission and those without, and (iii) identify the independent risk factors associated with heart failure admission.Methods and resultsThe Japan Acute Myocardial Infarction Registry is a prospective multicentre registry from which data on consecutively enrolled patients with AMI from 50 institutions between 2015 and 2017 were obtained. Among the 3411 patients enrolled, 3226 who survived until discharge were included in this study. The primary endpoint was all‐cause mortality. The secondary endpoints were major adverse cardiovascular events (defined as cardiovascular mortality, non‐fatal myocardial infarction, or non‐fatal cerebral infarction) and major bleeding events corresponding to Bleeding Academic Research Consortium Type 3 or 5. Clinical outcomes were compared between the patients who were and were not admitted for heart failure. Over a median follow‐up of 12 months, 124 patients (3.8%) were admitted due to heart failure. Independent risk factors for heart failure admission included older age, female sex, Killip class ≥2 on admission, left ventricular ejection fraction <40%, estimated glomerular filtration rate ≤30 mL/min/1.73 m2, a history of malignancy, and non‐use of angiotensin‐converting enzyme inhibitors at discharge. The cumulative incidence of all‐cause mortality was significantly higher in the heart failure admission group than in the no heart failure admission group (11.3% vs. 2.5%, P < 0.001). The rates of major adverse cardiovascular events (16.9% vs. 2.7%, P < 0.001) and major bleeding (6.5% vs. 1.6%, P < 0.001) were significantly higher in the heart failure admission group. Heart failure admission was associated with a higher risk of all‐cause mortality, even after adjusting for potential confounders (adjusted hazard ratio: 2.41, 95% confidence interval: 1.33–4.39, P = 0.004).ConclusionsUtilizing real‐world data of the contemporary percutaneous coronary intervention era from the Japan Acute Myocardial Infarction Registry database, this study demonstrates that the heart failure admission of AMI survivors was significantly associated with higher all‐cause mortality rates.
Relationship of interleukin‐16 with different phenogroups in acute heart failure with preserved ejection fraction
Authors: Tamaki Shunsuke , Sotomi Yohei , Nagai Yoshiyuki , Shutta Ryu , Masuda Daisaku , Makino Nobuhiko , Yamashita Shizuya , Seo Masahiro , Yamada Takahisa , Nakagawa Akito , Yasumura Yoshio , Nakagawa Yusuke , Yano Masamichi , Hayashi Takaharu , Hikoso Shungo , Nakatani Daisaku , Ohtani Tomohito , Sakata Yasushi ,   the OCVC‐Heart Failure Investigators
Published: April 2024

AbstractAimsInterleukin‐16 (IL‐16) has been reported to mediate left ventricular myocardial fibrosis and stiffening in patients with heart failure with preserved ejection fraction (HFpEF). We sought to elucidate whether IL‐16 has a distinct impact on pathophysiology and prognosis across different subphenotypes of acute HFpEF.Methods and resultsWe analysed 211 patients enrolled in a prospective multicentre registry of acute decompensated HFpEF for whom serum IL‐16 levels after stabilization were available (53% female, median age 81 [interquartile range 75–85] years). We divided this sub‐cohort into four phenogroups using our established clustering algorithm. The study endpoint was all‐cause death. Patients were subclassified into phenogroup 1 (‘rhythm trouble’ [n = 69]), phenogroup 2 (‘ventricular‐arterial uncoupling’ [n = 49]), phenogroup 3 (‘low output and systemic congestion’ [n = 41]), and phenogroup 4 (‘systemic failure’ [n = 52]). After a median follow‐up of 640 days, 38 patients had died. Among the four phenogroups, phenogroup 2 had the highest IL‐16 level. The IL‐16 level showed significant associations with indices of cardiac hypertrophy, diastolic dysfunction, and congestion only in phenogroup 2. Furthermore, the IL‐16 level had a significant predictive value for all‐cause death only in phenogroup 2 (C‐statistic 0.750, 95% confidence interval 0.606–0.863, P = 0.017), while there was no association between the IL‐16 level and the endpoint in the other phenogroups.ConclusionsOur results indicated that the serum IL‐16 level had a significant association with indices that reflect the pathophysiology and prognosis of HFpEF in a specific phenogroup in acute HFpEF.
Light‐assisted drying (LAD): A new process for producing an amorphous trehalose preservation matrix for the storage of biologics
Authors: Furr Daniel P. , Tsegaye Anteneh A. , Kern Madeline R. , Olson Gunnar , Ye Tang , Zhang Yong , Trammell Susan R. 
Published: April 2024

AbstractThe requirement for temperature‐controlled storage can be challenging and expensive for the transportation and storage of biologics. Light‐assisted drying (LAD) is a new processing technique to prepare biologics for storage in a trehalose amorphous solid matrix at ambient temperatures. Samples are illuminated with near‐infrared laser light to speed dehydration. Previous work has shown LAD can prepare small‐volume (40 μL) samples, but the feasibility of applying LAD to larger samples remains unexplored. Here, LAD is applied to large‐volume samples (250 μL). Samples of a trehalose solution with an embedded protein were LAD processed and stored for 1 month. The end moisture contents of samples were determined after processing and storage. Thermal histories were monitored to determine optimal drying times. The trehalose matrix was characterized using polarized light imaging and Raman spectroscopy. Karl‐Fischer (KF) titration was used to measure the water content. The end moisture contents and thermal histories show high repeatability for LAD processing. Polarized light imaging demonstrates that the trehalose matrix was resistant to crystallization. Raman spectroscopy indicates uniform water distribution and KF titration reveals a low average water content (2.5%). LAD can stabilize large‐volume samples for dry‐state storage at ambient temperatures and offers a potential solution for cold‐chain storage challenges.
Accelerated time history iteration method for offline real‐time hybrid testing
Authors: Guo Youming , Pan Peng 
Published: April 2024

AbstractReal‐time hybrid testing (RTHT) is an efficient method to simulate the dynamic behavior of complex engineering systems. A novel offline RTHT method has been developed in recent years, wherein the computation of the numerical substructure and the loading of the experimental substructure are independent. Offline RTHT has obvious advantages in terms of accuracy, stability, and cost compared with conventional online RTHT. However, due to the excessive number of iterations, the application range of the existing offline RTHT methods is limited. This paper proposes an accelerated time history iteration (ATHI) method based on system identification and virtual iteration. A two‐loop parameter optimization (TLPO) method is developed to obtain an accurate discrete transfer function. Virtual iterations are performed by replacing the real system with an identified transfer function, which can reduce the number of real iterations. Physical tests were performed on structures equipped with a tuned mass damper or active mass damper, where resonance, nonlinearity, closed‐loop control, and measurement noise exist. The test results suggest that the real system can be accurately represented by the identified transfer function when adopting the TLPO method. The proposed ATHI successfully accelerates the convergence process while ensuring stability and accuracy.
Early change in gastric‐specific anxiety sensitivity as a predictor of eating disorder treatment outcome
Authors: Velkoff Elizabeth A. , Lusich Rylee , Kaye Walter H. , Wierenga Christina E. , Brown Tiffany A. 
Published: April 2024

AbstractEating disorders (EDs) are often accompanied by gastrointestinal (GI) distress. Anxiety sensitivity is the tendency to interpret sensations of anxiety as threatening or dangerous, and includes both broad physical symptoms (e.g., elevated heartrate) and GI‐specific symptoms. Physical and GI‐specific anxiety sensitivity may be important risk and maintaining factors in EDs. This study tested the hypothesis that greater reductions in both types of anxiety sensitivity during the first month of treatment would predict lower ED symptoms and trait anxiety at discharge and 6‐month follow‐up. Patients (n = 424) in ED treatment reported physical and GI‐specific anxiety sensitivity, ED symptoms, and trait anxiety at treatment admission, 1‐month into treatment, discharge, and 6‐month follow‐up. Analyses were conducted with hierarchical linear regression with imputation, controlling for relevant covariates. Results indicated that early reduction in GI‐specific but not general physical anxiety sensitivity predicted both lower ED symptoms and lower trait anxiety at discharge and 6‐month follow‐up. These findings demonstrate the importance of GI‐specific anxiety sensitivity as a potential maintaining factor in EDs. Developing and refining treatments to target GI‐specific anxiety sensitivity may have promise in improving the treatment not only of EDs, but also of commonly co‐morbid anxiety disorders.
Seed morphology in the genus Matthiola R. Br. (Brassicaceae): Identification of species and systematic implications
Authors: Abdel Khalik Kadry N. , Al‐Juhani Widad S. 
Published: April 2024

AbstractSeed coat morphology of 34 species of Matthiola R.Br. has been studied using light and scanning electron microscopy to assess their investigative value for systematic studies. Macro‐ and micromorphological characters, including seed shape, color, size, wing, and radicle position relative to cotyledons, epidermal cell shape, anticlinal boundaries, and periclinal cell wall are presented. Seed shape, color, and radicle position relative to cotyledons have limited taxonomic significance, as their variation is unhelpful. There against, seed size, wing, and seed coat ornamentation present informative characteristics that can be used professionally in distinguishing the studied taxa. Six different types of seed anticlinal cell wall boundaries are recognized and five different outer periclinal cell wall shapes are described. The sculpture of the secondary cell wall varies from striate, micropapillate to microreticulate, and smooth to fine folds. The taxonomic and phylogenetic implications of seed coat micromorphology were compared with those of the existing gross morphological and molecular data. Seed character analysis offered useful data for evaluating the taxonomy of Matthiola both on subgeneric and sectional levels. Seed micromorphological characters provide evidence that M. odoratissima and M. ovatifolia should be preserved as separate species. In addition, M. ghorana is not conspecific with M. graminea. Furthermore, M. tricuspidata was unique in the seed characters. A key to the identification of the examined taxa based on seed characters is provided.
Pu‐erh tea reduces the transmission of CRD‐mediated alopecia risk to offspring
Authors: Hu Shanshan , Wang Jie , Lin Zhiyuan , Zhang Bowen , Luo Liyong , Zeng Liang 
Published: April 2024

AbstractCircadian rhythm disorder (CRD) is closely associated with hair regression and shedding, but whether this risk can be transmitted to the offspring is unknown. Whether Pu‐erh tea, with alleviating effects of CRD‐mediated syndrome, can act on the transmission of alopecia risk to offspring is also unproven. Here, we obtained CRD parental mice offspring and found that CRD‐mediated alopecia risk can be transmitted to offspring, especially male offspring. Parental consumption of Pu‐erh tea, especially in females or both parents, reduced the risk of CRD‐mediated alopecia transmitted to offspring by inhibiting subcutaneous fat accumulation (downregulation of Rab18, fat‐specific protein 27 (Fsp27), and perilipin 1 (Plin1)), reducing oxidative stress and inflammation in skin tissue (NADPH oxidase 4 (NOX4)/ nuclear factor kappa‐B (NF‐κB)), balancing androgen and hair growth factor release (hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), insulin‐like growth factor 1 (IGF‐1)), and restoring hair follicle DNA repair function (upregulation of Ku70, 8‐Oxoguanine DNA glycosylase 1 (OGG1), and Rad51). Transcriptomic analysis further clarified that the mechanism stemmed from the upregulation of gene expression in pathways such as the Wnt, Hippo, and other signaling pathways.
Advances in the Synthesis of Heterocycles with Two and Three Heteroatoms using Hydrazonoyl Halides
Authors: Yamaletdinova Nargiza R. , Gataullin Rail R. 
Published: April 2024

AbstractThe review covers the results of studies published in the literature on the use of hydrazonoyl halides in the synthesis of five‐ (pyrazoles, thiazoles, triazoles, oxa‐ and thiadiazoles), six‐ (oxa‐ and thiadiazines, indazoles, pyridazines, pyrazines, tetrazines) or seven‐membered (benzotriazepine) heterocycles. In the formation of these heterocycles, the main intermediate stage of the reaction is the in situ generation of nitrilimine, which enters into a cycloaddition reaction with substituted acetylenes (including in situ generated benzynes, naphthynes), allenes, activated olefins, anthranilic acid derivatives, organosulfur compounds (mercaptoaldehydes, mercaptocarboxylic acids) or with fused heterocycles. Examples are given of the formation of heterocycles by replacing the halogen atom from a hydrazonoyl halide molecule with a nucleophilic group, followed by exhaustive intramolecular cyclization into the target compound. There are discussions of reactions in which the cycloaddition of the nitrilimine to the in situ synthesized Knoevenagel condensation product (from CH‐acid compounds, such as di‐ and monocarbonyl compounds, dinitrile malonic acid) occurs, leading to spiro‐linked or conventional pyrazoles. Some syntheses of biologically active representatives are shown.
Perovskite solar cells with ferroelectricity
Authors: Zhang Tie , Luo Huiming , Abdi‐Jalebi Mojtaba , Chen Hongzheng , Zuo Lijian 
Published: April 2024

AbstractHalide perovskites show excellent optoelectronic properties for solar cell application. Notably, perovskite crystalline structures have been widely reported to deliver superior ferroelectric properties. As a result, the integration of the ferroelectric process with the photon‐to‐electron energy conversion process becomes feasible to generate interesting photo‐physical properties and further boost the device performance of perovskite solar cells (PSCs), which have started to attract more and more attention in recent years. Here, we have reviewed the recent progress in PSCs with ferroelectricity (FE‐PSCs), by classifying them into three regimes according to the degree of phase segregation, for example, the layer‐structured ferroelectric/halide perovskite composite, micro phase‐separated ferroelectric/halide perovskite composite, and the intrinsic ferroelectric halide perovskite composite. The different composite structures enable a large range of interesting optoelectronic properties and the specific structure significantly enhances the device performance of PSCs. The most prominent contribution of ferroelectricity is that it can provide an extra electrical field to drive charge generation, transport, and collection. Further, key challenges and opportunities of the integration of ferroelectricity with photovoltaics are discussed. We hope our work can draw intensive attention in this field to accelerate the establishment of the basic theories in ferroelectricity and the commercialization of PSCs.
Polyp segmentation network based on lightweight model and reverse attention mechanisms
Authors: Long Jianwu , Yang Chengxin , Song Xinlei , Zeng Ziqin , Ren Yan 
Published: April 2024

AbstractColorectal cancer is a common gastrointestinal malignancy. Early screening and segmentation of colorectal polyps are of great clinical significance. Colonoscopy is the most effective method to detect polyps, but some polyps may be missed in the detection process. On this basis, the use of computer‐aided diagnosis technology is particularly important for colorectal polyp segmentation. To improve the detection rate of intestinal polyps under colonoscopy, a polyp segmentation network (MobileRaNet) based on a lightweight model and reverse attention (RA) mechanism was proposed to accurately segment polyps in colonoscopy images. The coordinated attention module is used to improve MobileNetV3 and make it the backbone network (CaNet). Second, a part of the output of the high‐level feature from the backbone network is passed into the parallel axial receptive field module (PA_RFB) to extract the global dependency representation without losing the details. Third, a global map is generated based on this combined feature as the initial boot area of the subsequent components. Finally, the RA module is used to mine the target region and boundary clues to improve the segmentation accuracy. To verify the effectiveness and lightweight performance of the algorithm, five challenging datasets, including CVC‐ColonDB, CVC‐300, and Kvasir, are used in this paper. In six indexes, including MeanDice, MeanIoU, and MAE, compared with seven typical models such as PraNet and TransUnet, accuracy, FLOPs, parameters, and FPS were compared. The experimental results show that the MobileRaNet proposed in this paper has improved the performance of the five datasets to varying degrees, especially the MeanDice and MeanIOU indexes of the Kvasir dataset reach 91.2% and 85.6%, which are, respectively, increased by 1.4% and 1.6% compared with PraNet. Compared with PraNet, FLOPs and parameters decreased by 83.3% and 76.7%, respectively.
Self‐powered sensor based on compressible ionic gel electrolyte for simultaneous determination of temperature and pressure
Authors: Zou Junjie , Ma Yanan , Liu Chenxu , Xie Yimei , Dai Xingyao , Li Xinhui , Li Shuxuan , Peng Shaohui , Yue Yang , Wang Shuo , Nan Ce‐Wen , Zhang Xin 
Published: April 2024

AbstractThe simultaneous detection of multiple stimuli, such as pressure and temperature, has long been a persistent challenge for developing electronic skin (e‐skin) to emulate the functionality of human skin. Meanwhile, the demand for integrated power supply units is an additional pressing concern to achieve its lightweightness and flexibility. Herein, we propose a self‐powered dual temperature–pressure (SPDM) sensor, which utilizes a compressible ionic gel electrolyte driven by the potential difference between MXene and Al electrodes. The SPDM sensor exhibits a rapid and timely response to changes in pressure‐induced deformation, while exhibiting a slow and hysteretic response to temperature variations. These distinct response characteristics enable the differentiation of current signals generated by different stimuli through machine learning, resulting in an impressive accuracy rate of 99.1%. Furthermore, the developed SPDM sensor exhibits a wide pressure detection range of 0–800 kPa and a broad temperature detection range of 5–75°C, encompassing the environmental conditions encountered in daily human life. The dual‐mode coupled strategy by machine learning provides an effective approach for temperature and pressure detection and discrimination, showcasing its potential applications in wearable electronics, intelligent robots, human–machine interactions, and so on.
Lack of women physician representation in the Japanese Society of Hospital General Medicine
Authors: Shiota Seiji , Utsunomiya‐Nishimizu Rie , Goto Ryo , Hirabayashi Ayana , Horinouchi Noboru , Doi Eri , Yoshimura Katsuhiko , Yamamoto Kyoko , Yoshiiwa Aoi , Miyazaki Eishi 
Published: April 2024

AbstractBackgroundThe increasing number of women physicians is in contrast to their underrepresentation in academic positions and professional associations. This study aimed to evaluate the status of women physicians in the Japanese Society of Hospital General Medicine (JHGM) based on society membership, board membership, and annual meeting authorship.MethodsA cross‐sectional analysis was conducted. Information on women physicians, society and board membership, and annual meeting authorship was collected. Data from the Japanese Primary Care Association (JPCA) served as the control. The gender of authors with accepted abstracts in the JHGM and JPCA annual meetings was determined by name or Internet search.ResultsIn the JHGM, 14.2% of members were women physicians, compared to 19.1% in the JPCA (p < 0.001). None of the 21 JHGM board members were women, compared to 20.5% in the JPCA (p < 0.001). The average number of years of experience was significantly higher for the JHGM board members than for the JPCA board members (37.0 vs. 28.1 years, p < 0.001). Women first authors in the 2022–2023 JHGM meeting comprised 17.9%, significantly lower than the 28.4% in the 2023 JPCA meeting (p = 0.002). Similar patterns were seen for women last authors (6.0% in the JHGM vs. 18.8% in the JPCA, p < 0.001) and women chairpersons (17.9% in the JHGM vs. 40.3% in the JPCA, p = 0.036).ConclusionsThe JHGM has low women representation in society and board membership, and annual meeting authorship. Strategies are needed to enhance diversity and inclusion by increasing women's participation and leadership in the JHGM.
Timing and prediction of secondary bacteremia in patients with COVID‐19: A retrospective cohort study
Authors: Yogo Aoi , Yamamoto Shungo , Tochitani Kentaro 
Published: April 2024

AbstractBackgroundWe aimed to aid the appropriate use of antimicrobial agents by determining the timing of secondary bacteremia and validating and updating clinical prediction models for bacteremia in patients with COVID‐19.MethodsWe performed a retrospective cohort study on all hospitalized patients diagnosed with COVID‐19 who underwent blood culture tests from January 1, 2020, and September 30, 2021, at an urban teaching hospital in Japan. The primary outcome measure was secondary bacteremia in patients with COVID‐19.ResultsOf the 507 patients hospitalized with COVID‐19, 169 underwent blood culture tests. Eleven of them had secondary bacteremia. The majority of secondary bacteremia occurred on or later than the 9th day after symptom onset. Positive blood culture samples collected on day 9 or later after disease onset had an odds ratio of 22.4 (95% CI 2.76–181.2,p < 0.001) compared with those collected less than 9 days after onset. The area under the receiver operating characteristic curve of the modified Shapiro rule combined with blood culture collection on or after the 9th day from onset was 0.919 (95% CI, 0.843–0.995), and the net benefit was high according to the decision curve analysis.ConclusionsThe timings of symptom onset and hospital admission may be valuable indicators for making a clinical decision to perform blood cultures in patients hospitalized with COVID‐19.