bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward a Better Understanding of Psychological Well‐Being in Dementia Caregivers: The Link Between Marital Communication and Depression
Authors: BRAUN MELANIE , MURA KATHARINA , PETER‐WIGHT MELANIE , HORNUNG RAINER , SCHOLZ URTE 
Published: May 2010

To read this article's abstract in both Spanish and Mandarin Chinese, please visit the article's full‐text page on Wiley InterScience (http://interscience.wiley.com/journal/famp).Dementia research has frequently documented high rates of caregiver depression and distress in spouses providing care for a partner suffering from dementia. However, the role of marital communication in understanding caregiver distress has not been examined sufficiently. Studies with healthy couples demonstrated an association between marital communication and the partners' psychological well‐being, depressiveness, respectively (e.g., Heene, Buysee, & Van Oost, 2005). The current study investigates the relationship between caregiver depression and communication in 37 couples in which the wives care for their partners with dementia. Nonsequential and sequential analyses revealed significant correlations between caregiver depression and marital communication quality. Caregivers whose husbands used more positive communication reported less depression and distress. Additionally, caregiver depression was negatively correlated with rates of positive reciprocal communication indicating dependence between the couples' interaction patterns. This study is one of the first to illustrate the relevance of spousal communication in understanding caregiver distress and depression.
Structural Ecosystems Therapy for HIV+ African‐American Women and Drug Abuse Relapse
Authors: FEASTER DANIEL J. , BURNS MYRON J. , BRINCKS AHNALEE M. , PRADO GUILLERMO , MITRANI VICTORIA B. , MAUER MEGALY H. , SZAPOCZNIK JOSE 
Published: May 2010

To read this article's abstract in both Spanish and Mandarin Chinese, please visit the article's full‐text page on Wiley InterScience (http://interscience.wiley.com/journal/famp).This report examines the effect of Structural Ecosystems Therapy (SET) for (n=143) HIV+ African‐American women on rate of relapse to substance use relative to both a person‐centered approach (PCA) to therapy and a community control (CC) group. A prior report has shown SET to decrease psychological distress and family hassles relative to these 2 comparison groups. In new analyses, SET and CC had a significant protective effect against relapse as compared with PCA. There is evidence that SET's protective effect on relapse was related to reductions in family hassles, whereas there was not a direct impact of change in psychological distress on rates of relapse. Lower retention in PCA, perhaps caused by the lack of a directive component to PCA, may have put these women at greater risk for relapse. Whereas SET did not specifically address substance abuse, SET indirectly protected at‐risk women from relapse through reductions in family hassles.
A Dyadic Analysis of the Between‐ and Within‐System Alliances on Distress
Authors: ANDERSON SHAYNE R. , JOHNSON LEE N. 
Published: May 2010

To read this article's abstract in both Spanish and Mandarin Chinese, please visit the article's full‐text page on Wiley InterScience (http://interscience.wiley.com/journal/famp).This study examines the relationship between the therapeutic alliance and distress using the couple rather than the individual as the unit of analysis. One hundred and seventy‐three couples receiving treatment for relational distress at two university clinics participated in this study. The actor–partner interdependence model was used to analyze the relationship of each partner's between‐ and within‐system alliance scores and distress at session four. Results provide support for actor effects on relational distress for both male and female partners and for actor effects on psychological distress for female partners. Limited support was found for partner effects on distress. Furthermore, results indicate that the alliance between partners is a stronger predictor of improvement in early sessions in comparison with the alliance between the individual and the therapist.
Family Microtransitions: Observing the Process of Change in Families with Adolescent Children
Authors: MOLINARI LUISA , EVERRI MARINA , FRUGGERI LAURA 
Published: May 2010

To read this article in Spanish, please see this article's Supporting Information on Wiley InterScience (http://interscience.wiley.com/journal/famp). To read this article's abstract in both Spanish and Mandarin Chinese, please visit the article's full‐text page on Wiley InterScience (http://interscience.wiley.com/journal/famp).The aim of the study is to explore the process of microtransitions in families with adolescent children. Original methodological procedures were designed in order to have families as the objects of study and to analyze data with particular attention to the family process of change. A family interview focused on the adolescent and family change was conducted with 12 families having an adolescent child. As indicators of change, we used coordination and oscillation. Our results highlight different patterns of family interactions, illustrating various ways through which families deal with change. Conclusive remarks focus on the theoretical relevance of the study, the method and the implications for family practice and policy.
Beyond the “Birds and the Bees”: Gender Differences in Sex‐Related Communication Among Urban African‐American Adolescents
Authors: KAPUNGU CHISINA TSVAKAYI , BAPTISTE DONNA , HOLMBECK GRAYSON , MCBRIDE CAMI , ROBINSON‐BROWN MELISSA , STURDIVANT ALLYSE , CROWN LAUREL , PAIKOFF ROBERTA 
Published: May 2010

To read this article's abstract in both Spanish and Mandarin Chinese, please visit the article's full‐text page on Wiley InterScience (http://interscience.wiley.com/journal/famp).The current study examined gender differences in communication about sex‐related topics in a community sample of urban, African‐American mothers and adolescents living in impoverished neighborhoods with high HIV rates. One hundred and sixty‐two mother–adolescent dyads completed self‐report measures of sex‐related communication. Youth also reported on their sexual risk. We identified the range of sexual‐based topics that adolescents discussed with their mothers, fathers, friends, and at school. The relationship between the frequency of sexual communication and sexual risk was examined. We also investigated congruency between adolescent and mother report about whether sexual‐based discussions occurred. Consistent with prior research, girls talked to their mothers, fathers, friends, and at school about sex‐related topics more than boys. Findings indicated that mothers not only communicated more frequently about sexual issues with their daughters than sons but that parental messages for girls were more protective. Greater sexual communication with mother was significantly associated with decreased HIV risk in the past 90 days and increased protection from HIV. Inconsistencies between mother and adolescent reports about sexual communication were marginally associated with decreased protection from HIV. Findings reveal the protective effect of sexual communication and the general lack of congruence between mother and adolescent reports of sexual communication.
The STTI Practice‐Academe Innovative Collaboration Award: Honoring Innovation, Partnership, and Excellence
Authors: Kirschling Jane Marie , Erickson Jeanette Ives 
Published: May 2010

Abstract Purpose: To describe the benefits and barriers associated with practice‐academe partnerships and introduce Sigma Theta Tau International's (STTI's) Practice‐Academe Innovative Collaboration Award and the 2009 award recipients. Design and Methods: In 2008, STTI created the CNO‐Dean Advisory Council and charged it with reviewing the state of practice‐academe collaborations and developing strategies for optimizing how chief nursing officers (CNOs) and deans work together to advance the profession and discipline of nursing. The Council, in turn, developed the Practice‐Academe Innovative Collaboration Award to encourage collaboration across sectors, recognize innovative collaborative efforts, and spotlight best practices. A call for award submissions resulted in 24 applications from around the globe. Findings: An award winner and seven initiatives receiving honorable mentions were selected. The winning initiatives reflect innovative academe‐service partnerships that advance evidence‐based practice, nursing education, nursing research, and patient care. The proposals were distinguished by their collaborators’ shared vision and unity of purpose, ability to leverage strengths and resources, and willingness to recognize opportunities and take risks. Conclusions: By partnering with one another, nurses in academe and in service settings can directly impact nursing education and practice, often effecting changes and achieving outcomes that are more extensive and powerful than could be achieved by working alone. Clinical Relevance: The award‐winning initiatives represent best practices for bridging the practice‐academe divide and can serve as guides for nurse leaders in both settings.
The effect of diet on total antioxidant status, ceruloplasmin, transferrin and ferritin serum levels in phenylketonuric children
Authors: Schulpis Kleopatra H , Papastamataki Maria , Stamou Helen , Papassotiriou Ioannis , Margeli Alexandra 
Published: May 2010

AbstractObjectives:  To investigate the effect of diet on total antioxidative status (TAS), transferrin, ferritin and ceruloplasmin serum levels in phenylketonuric (PKU) children.Patients and methods:  Seventeen poorly controlled PKU children underwent clinical and laboratory examinations before, ‘off diet’, and 60 days after adhering to their special diet ‘on diet’, whereas controls (N = 24) were examined once. Blood chemistry was performed with the appropriate methodologies.Results:  Phenylalanine levels differed significantly among the examined groups. Lipids and lipoproteins were higher in ‘off diet’ than in ‘on diet’ group, except of high density lipoprotein and apolipoprotein AI that remained unaffected. Total antioxidative status (386 ± 30 vs 204 ± 23 μmol/L, p < 0.001), ferritin (48.2 ± 2.3 vs 33.0 ± 2.8 μg/L, p < 0.001) and ceruloplasmin (40.02 ± 2.5 vs 25.5 ± 2.8 mg/dL, p < 0.001) levels were significantly higher in ‘on diet’ patients’ group compared to ‘off diet’ one. The low lipoprotein and the high TAS and ferritin levels in patients with PKU ‘on diet’ may be related to the vegetarian diet and the rich in iron formula supplementation.Conclusions:  The low ferritin levels found in ‘off diet’ patients with PKU may be attributed to a decreased liver production of ceruloplasmin, which evaluation may be a useful tool for the follow‐up of patients with PKU.
The E3 ubiquitin ligase Itch regulates sorting nexin 9 through an unconventional substrate recognition domain
Authors: Baumann Claudia , Lindholm Cecilia K. , Rimoldi Donata , Lévy Frédéric 
Published: May 2010

The level of intracellular proteins is mainly regulated through modifications by ubiquitin ligases that target them for degradation. Members of the NEDD4 family of E3 ubiquitin ligases, such as Itch (atrophin‐1 interacting protein 4), possess up to four WW domains for specific association with PY motif‐containing substrates. We have identified sorting nexin 9 (SNX9), a protein involved in endocytic processes, as a new substrate of Itch. Itch ubiquitylates SNX9 and regulates intracellular SNX9 levels. Using truncated proteins, we found that the interaction with SNX9 is mediated by the proline‐rich domain (PRD) of Itch, a domain distinct from the conventional WW recognition domain, and the SH3 domain of SNX9. Interaction with the PRD of Itch is essential for SNX9 ubiquitylation and degradation. Furthermore, this effect is specific for Itch, as NEDD4, a related PRD‐containing E3 ligase, does not bind SNX9. SNX18, a second member of the SNX family containing an SH3 domain, was also found to bind to Itch. Our results indicate that the pool of substrates of NEDD4 family E3 ubiquitin ligases extends beyond proteins containing PY motifs.Structured digital abstract
MINT‐7889719: SNX18 (uniprotkb:Q96RF0) physically interacts (MI:0915) with ITCH (uniprotkb:Q96J02) by anti tag coimmunoprecipitation (MI:0007)
MINT‐7889571, MINT‐7889619: ITCH (uniprotkb:Q96J02) physically interacts (MI:0915) with SNX9 (uniprotkb:Q9Y5X1) by pull down (MI:0096)
MINT‐7889653: Melan‐A (uniprotkb:Q16655) physically interacts (MI:0914) with NEDD4 (uniprotkb:P46934) and ITCH (uniprotkb:Q96J02) by pull down (MI:0096)
MINT‐7889591, MINT‐7889673, MINT‐7890033: SNX9 (uniprotkb:Q9Y5X1) physically interacts (MI:0915) with ITCH (uniprotkb:Q96J02) by anti tag coimmunoprecipitation (MI:0007)
MINT‐7889689: SNX9 (uniprotkb:Q9Y5X1) physically interacts (MI:0914) with ITCH (uniprotkb:Q96J02) and Ubiquitin (uniprotkb:P62988) by anti tag coimmunoprecipitation (MI:0007)
MINT‐7889928: Ub (uniprotkb:P62988) physically interacts (MI:0915) with SNX9 (uniprotkb:Q9Y5X1) by anti tag coimmunoprecipitation (MI:0007)
MINT‐7889610: SNX9 (uniprotkb:Q9Y5X1) physically interacts (MI:0915) with ITCH (uniprotkb:Q96J02) by anti bait coimmunoprecipitation (MI:0006)
Comparative Cardiac Gene Delivery of Adeno‐Associated Virus Serotypes 1–9 reveals that AAV6 Mediates the Most Efficient Transduction in Mouse Heart
Authors: Zincarelli Carmela , Soltys Stephen , Rengo Giuseppe , Koch Walter J. , Rabinowitz Joseph E. 
Published: May 2010

AbstractCardiac gene transfer is an attractive tool for developing novel heart disease treatments. Adeno‐associated viral (AAV) vectors are widely used to mediate transgene expression in animal models and are being evaluated for human gene therapy. However, it is not clear which serotype displays the best cardiac tropism. Therefore, we curried out this study to directly compare AAV serotypes 1–9 heart transduction efficiency after indirect intracoronary injection. AAV‐cytomegalovirus immediate early enhancer promoter (CMV)‐luciferase serotypes 1–9 were injected in the left ventricular cavity of adult mice, after cross‐clamping the ascending aorta and pulmonary artery. An imaging system was used to visualize luciferase expression at 3, 7, 21, 70, and 140 days postinjection. Echocardiography was performed to evaluate cardiac function on day 140. At the end of the study, luciferase enzyme activity and genome copies of the different AAV serotypes were assessed in several tissues and potential AAV immunogenicity was evaluated on heart sections by staining for macrophage and lymphocyte antigens. Among AAV serotypes 1–9, AAV6 showed the best capability of achieving high transduction levels in the myocardium in a tissue‐specific manner, whereas the other serotypes had less cardiac transduction and more extracardiac expression, especially in the liver. Importantly, none of the serotypes tested with this marker gene affected cardiac function nor was associated with inflammation.
Designing an “Architecture of Information”— The United States Holocaust Memorial Museum
Authors: Appelbaum Ralph 
Published: May 2010

ABSTRACTFor the permanent exhibition at the United States Holocaust Memorial Museum the design approach was minimal and transparent, and the designers were in dialogue only with the story — not with the history of design or the conventions governing most museum presentations. We reached for a sense of immersion by trying to erase the seams between exhibits and architecture. Display strategies included the removal of conventional barriers of certain glass‐encased vitrines: some objects can be touched, and reactions sought are as visceral as they are intellectual. We tried above all to see that people leave the museum not profoundly dejected but with some other feeling evoking the resilience of life and hope. The design intended to make the environment so united with its subject that memory of the museum experience and the sharing of memory through discussion will carry on in the lives of the visitors.
Museum Fever in France
Authors: Grasset Constance Dedieu 
Published: May 2010

ABSTRACTIn the 1980s, a wave of construction and renovation swept through the French museum world. It was driven by the need to renovate badly deteriorating museums and a growing awareness of the importance and potential of museums for tourism, economic dynamism, and local prestige. Until the early 1990s, a new museum opened every month, covering an impressive scale of subjects from art and archaeology to salt and combs. The French museum has witnessed many relatively sudden changes, some of them bringing French practice closer to American methods. But change is selective, and the French museum remains typically French. Recent developments are here evaluated in the dual context of the history of French museums and the ways in which they differ from the American style.
Developing Family‐Friendly Exhibits
Authors: Borun Minda , Dritsas Jennifer 
Published: May 2010

ABSTRACTHow can museums encourage active family learning? Four Philadelphia area science institutions—The Franklin Institute Science Museum, the New Jersey State Aquarium, the Academy of Natural Sciences, and the Philadelphia Zoo—have investigated the answer to this question as part of the PISEC (Philadelphia‐Camden Informal Science Education Collaborative) Family Learning Project. PISEC is conducting research and exhibit development aimed at increasing understanding of family learning in science museums and identifying the characteristics of successful family learning exhibits. The PISEC project has three phases, two of which have been completed: (1) a research study to establish behavioral indicators for family learning; (2) the development and evaluation of four exhibit enhancements aimed at achieving family learning goals; (3) a research study of the impact of the four enhanced exhibits.This article will describe the results of formative evaluation conducted during Phase 2 of the project. “Family learning components,” or exhibit enhancements, designed to help adults and children learn together, were developed, field‐tested, revised, and installed at each of the four museums. PISEC has identified seven characteristics of successful family learning exhibits: multi‐sided, multi‐user, accessible, multi‐outcome, multi‐modal, readable, and relevant. The four PISEC family learning components, embodying these characteristics, appear to have increased active family learning.
Functional regulation of vascular and platelet activity during thrombosis by nitric oxide and endothelial nitric oxide synthase
Authors: Moore Christopher , Tymvios Charalambos , Michael Emerson 
Published: May 2010

SummaryNitric oxide (NO) regulates both vascular tone and platelet function. Since thrombotic diseases and their animal models consist of both vascular and platelet components, the functional mechanisms by which NO and endothelial nitric oxide synthase (eNOS) regulate thrombotic events are unclear. Experiments were conducted by measuring collagen-induced aggregation of freely circulating radio-labelled platelets in the pulmonary vasculature of anaesthetised mice via external detection probes. In addition, cardiac haemodynamic function was assessed by invasive catheterisation during thrombotic stimulation. Platelet aggregation responses were shown to occur independently of changes in vessel tone induced by pharmacological vasoconstriction or vasodilatation. Acute NOS inhibition significantly potentiated the amplitude and duration of platelet aggregation and an NO donor had an inhibitory effect. In contrast, in eNOS−/− mice, the amplitude of platelet aggregation was not affected although the response was protracted following moderate thrombotic stimulation. Thrombosis induced changes in haemodynamic performance were sensitive to vasomodulation and were potentiated by both NOS inhibition and in eNOS−/− mice. In conclusion, endogenous NO and exogenously applied NO donors exert an antithrombotic effect in vivo through a direct suppression of platelet aggregation. In contrast, eNOS exerts a powerful antithrombotic effect upon the vascular components of thrombosis but has a more subtle effect on the duration of thrombotic responses that are platelet-mediated. Our data demonstrate the differential roles of eNOS and general NO bioavailability in regulating vascular and platelet activity during thrombosis.
Multi-Reanalysis Climatology of Intermountain Cyclones
Authors: Jeglum Matthew E. , Steenburgh W. James , Lee Tiros P. , Bosart Lance F. 
Published: May 2010

Abstract
The topography in and around the Intermountain West strongly affects the genesis, migration, and lysis of extratropical cyclones. Here intermountain (i.e., Nevada or Great Basin) cyclone (IC) activity and evolution are examined using the ECMWF Re-Analysis Interim (ERA-Interim) the North American Regional Reanalysis (NARR), and the NCEP–NCAR reanalysis from 1989 to 2008, the period during which all three are available. The ICs are defined and tracked objectively as 850-hPa geopotential height depressions of ≥40 m that persist for ≥12 h.
The monthly distribution of IC center and genesis frequency in all three reanalyses is bimodal with spring (absolute) and fall (secondary) maxima. Although the results are sensitive to differences in resolution, topographic representation, and reanalysis methodology, both the ERA-Interim and NARR produce frequent IC centers and genesis in the Great Basin cyclone region, which extends from the southern “high” Sierra to northwest Utah, and the Canyonlands cyclone region, which lies over the upper Colorado River basin of southeast Utah. The NCEP–NCAR reanalysis fails to resolve these two distinct cyclone regions and produces less frequent IC centers and genesis than the ERA-Interim and NARR.
An ERA-Interim-based composite of strong ICs generated in cross-Sierra (210°–300°) 500-hPa flow shows that cyclogenesis is preceded by the development of the Great Basin confluence zone (GBCZ), a regional airstream boundary that extends downstream from the Sierra Nevada across the Intermountain West. Cyclogenesis occurs along the GBCZ as large-scale ascent develops over the Intermountain West in advance of an approaching upper-level trough. Flow splitting around the high Sierra and the presence of low-level baroclinicity along the GBCZ suggest that IC evolution may be better conceptualized from a potential vorticity perspective than from traditional quasigeostrophic models of lee cyclogenesis. Although these results provide new insights into IC activity and evolution, analysis uncertainty and the cyclone identification criteria are important sources of ambiguity that cannot be fully eliminated.