bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fine‐needle aspiration biopsy of breast adenomyoepithelioma: A potential false positive pitfall and presence of intranuclear cytoplasmic inclusions
Authors: Saad Reda S. , Richmond Lara , Nofech‐Mozes Sharon , Ghorab Zeina 
Published: May 2011

AbstractCytologic diagnosis of adenomyoepithelioma can be very challenging. We report fine needle aspiration cytology (FNAC) findings of a benign adenomyoepithelioma. The cytologic features are characterized by hypercellularity and the presence of numerous atypical dispersed cells with epithelioid morphology and intact cytoplasm. The nuclei showed stippled chromatin, irregular nuclear membrane, and prominent eosinophilic nucleoli. No necrosis or mitoses were seen. The presence of naked nuclei, and extensive intranuclear cytoplasmic inclusions were identified and raised the possibility of adenomyoepithelioma. Immunohistochemically, the atypical cells showed strong positivity for myosin heavy chain, p63, and CK5/6, while the epithelial cells reacted with estrogen receptors. This immunophenotypic pattern supports the myoepithelial origin of the atypical cell proliferation and favors the diagnosis of benign adenomyoepithelioma. However, biopsy was recommended to exclude malignancy. Histologically, the tumor showed prominent myoepithelial cells with significant atypia, intranuclear cytoplasmic inclusions, and dense cytoplasm. No evidence of malignancy was identified. In conclusion, we report a case of adenomyoepithelioma with a significant cytological atypia that may result in confusion with malignant breast tumors. The presence of intranuclear cytoplasmic inclusions, naked nuclei, and expression of myoepithelial markers should provide clues to the right diagnosis and benign nature of this lesion. Cytopathologists should be familiarized with this entity to avoid a misdiagnosis of carcinoma. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.
Intranuclear peudoinclusions: Morphology, pathogenesis, and significance
Authors: Arora Sandeep Kumar , Dey Pranab 
Published: May 2011

AbstractIntranuclear pseudoinclusions represent invaginations of the cytoplasm into the nucleus. The nuclear pseudoinclusions are generally easier to appreciate in cytological preparations than frozen sections or histopathology thus forming an important cytological feature. In the present article we have reviewed the morphology, pathogenesis, differential diagnosis, and clinical significance of intranuclear cytoplasmic pseudoinclusion. Diagn.Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.
Primary Ewing's sarcoma/primitive neuroectodermal tumor of the kidney: Report of a case diagnosed by fine needle aspiration cytology and confirmed by immunocytochemistry and RT‐PCR along with review of literature
Authors: Kumar Rajiv , Gautam Upasana , Srinivasan Radhika , Lal Anupam , Sharma Upender , Nijhawan Raje , Kumar Santosh 
Published: May 2011

AbstractPrimary Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET) of the kidney is a distinct entity that can be mistaken for variety of round cell tumors. We report a rare case of ES/PNET of the kidney in a 35‐year‐old female patient diagnosed by fine needle aspiration cytology (FNAC) and confirmed by immunohistochemistry (IHC) and reverse‐transcriptase polymerase chain reaction (RT‐PCR). Ultrasound guided FNAC smears from the kidney mass showed a population of malignant small round cells with perivascular arrangement and focal rosette formation. IHC performed on the cell block, showed strong immunopositivity for CD99 (MIC2) and vimentin. Molecular analysis of the aspirate by RT‐PCR confirmed the EWS‐FLI type1 transcript. The application of RT‐PCR on FNAC material for establishing a diagnosis of renal ES/PNET is being reported for the first time. FNAC also confirmed metastases in the right level I cervical lymph node. The utility of IHC and molecular techniques in diagnosis of such a rare case is stressed and relevant literature is discussed. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.
Cytological diagnostic clues in fine needle aspiration of breast myofibroblastoma: A case report
Authors: Landeyro Julieta , Díaz M. Luisa , Raventós Antoni , Vadillo Jordi , Martínez M. Salomé 
Published: May 2011

AbstractMyofibroblastoma of the breast is a rare, benign mesenchymal tumor derived from the stroma and tends to occur mainly in middle‐aged to elderly men. There are a few cases reported in the literature describing its cytological features. We report the cytological and histological findings of a breast myofibroblastoma in a 68‐year‐old man. He presented with a palpable nodule of 2‐months duration in his left breast. The cytological smears obtained by fine needle aspiration showed less cohesive cellularity in a fascicular arrangement consisting of spindle cells with elongated cytoplasm, occasional nuclear grooves, and intranuclear cytoplasmic inclusions associated to fragments of stromal collagen. The cytological diagnosis was a mesenchymal proliferation suggesting the possibility of myofibroblastoma which was confirmed on histopathological examination. The breast myofibroblastoma has distinctive cytological features that in conjunction with the clinical and radiological data allow a specific diagnosis. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.
Acral myxoinflammatory fibroblastic sarcoma fine needle aspiration: A case report
Authors: Wickham M. Quinn , Youens Kenneth E. , Dodd Leslie G. 
Published: May 2011

AbstractCytological diagnosis of low grade sarcomas can be a daunting task, owing to the varied cytomorphological appearances possible. We report a case of acral myxoinflammatory fibroblastic sarcoma (AMIFS) in a woman who presented with a longstanding mass on the dorsum of her left foot. The diagnosis was suggested by fine needle aspiration cytology and established by wide excision. Microscopic examination showed that fine needle aspirate smears of this lesion contained the characteristic features seen in the surgical excision of this AMIFS: myxoid material, spindled to epithelioid cells with variably prominent nucleoli, nuclear pseudoinclusions, bipolar cytoplasmic extensions, globules of extracellular material, and bizarre virocyte or ganglion‐like giant cells. Diagn. Cytopathol. 2012. © 2012 Wiley Periodicals, Inc.
Fine‐needle aspiration features of paraduodenal pancreatitis (groove pancreatitis): A report of three cases
Authors: Chute Deborah J. , Stelow Edward B. 
Published: May 2011

AbstractChronic pancreatitis is notorious for mimicking both the clinical and radiologic presentation of pancreatic carcinoma. Paraduodenal pancreatitis is believed to result from focal chronic pancreatitis which affects the minor papilla of the duodenum. Currently, there is limited information available regarding the cytologic features of paraduodenal pancreatitis. In this study, we report the cytologic features of three patients with paraduodenal pancreatitis who had EUS‐guided FNAs of the pancreas. The cytologic features were highly variable between cases, likely due to sampling of the various components of paraduodenal pancreatitis. The most common findings were spindled stromal cells, foamy cells, and granular debris. Although most often interpreted as negative for malignancy, the sampling of an area with abundant spindle cells or Brunner gland hyperplasia can mimic neoplasia. Careful attention to the clinical history and radiologic description can help to prevent over‐diagnosis on FNA. Diagn. Cytopathol. 2011;. © 2011 Wiley Periodicals, Inc.
The potential impact of climate change on groundwater‐fed wetlands in eastern England
Authors: Herrera‐Pantoja M. , Hiscock K. M. , Boar R. R. 
Published: May 2011

ABSTRACTWetlands are fragile ecosystems that provide a range of useful functions. However, such ecosystems have been experiencing persistent pressures and stresses from a range of socio‐economic drivers in the last few centuries. In the 21st century, changes in global climate are expected to have impacts on hydrological and water supply regimes, which will in turn impose additional pressures on wetlands. Consequently, the need for quantitative methods to evaluate the likely impact of climate change is essential if appropriate conservation strategies and integrated water management regimes are to be developed. In this paper, a methodology is presented to evaluate the implications of potential climate change on groundwater‐fed wetlands underlain by an unconfined limestone (Chalk) aquifer in eastern England, one of the most vulnerable regions to climate change in the UK. A daily weather generator, a recharge model and a groundwater model have been coupled to investigate the most extreme consequences of future climate change as described by the UKCIP02 ‘high’ greenhouse gas emissions scenario. Simulations showed that a declining trend in wetland water levels could result in loss of species with a small tolerance to dry conditions by the end of the 21st century. Copyright © 2011 John Wiley & Sons, Ltd.
Binuclear Pentalene Iron Carbonyl Complexes
Authors: Li Huidong , Feng Hao , Sun Weiguo , Xie Yaoming , King R. Bruce , Schaefer Henry F. 
Published: May 2011

AbstractThe bicyclic hydrocarbon pentalene, although unstable in the free state, forms a stable iron carbonyl derivative cis‐(η5,η5‐C8H6)Fe2(CO)4(μ‐CO). In this connection, the series of binuclear pentalene iron carbonyl derivatives C8H6Fe2(CO)n (n = 7, 6, 5, 4) have been investigated by density functional theory. The lowest energy C8H6Fe2(CO)6 structure is predicted to be trans‐(η5,η5‐C8H6)Fe2(CO)6 without an iron–iron bond. However, a cis‐(η5,η1‐C8H6)Fe2(CO)6 structure with an uncomplexed pentalene C=C double bond and a formal Fe–Fe bond of length 2.646 Å (BP86) lies only ca. 3 kcal/mol above this global minimum. The CO dissociation energy of C8H6Fe2(CO)6 to give C8H6Fe2(CO)5 is predicted to be only ca. 12 kcal/mol, explaining the formation of C8H6Fe2(CO)5 rather than C8H6Fe2(CO)6 in reactions of dihydropentalene with iron carbonyls. In addition, the experimentally known cis‐(η5,η5‐C8H6)Fe2(CO)4(μ‐CO) structure is found to be the lowest energy C8H6Fe2(CO)5 structure by more than 25 kcal/mol (BP86). For the tetracarbonyl two triplet and two singlet cis‐C8H6Fe2(CO)4 structures lie within 7 kcal/mol of each other (BP86) with the triplet structures being of slightly lower energies. The singlet C8H6Fe2(CO)4 structure is predicted to be thermodynamically unfavorable with respect to disproportionation into C8H6Fe2(CO)5 + C8H6Fe2(CO)3.
Synthesis and Olfactory Characterization of Novel Silicon‐Containing Acyclic Dienone Musk Odorants
Authors: Geyer Marcel , Bauer Jennifer , Burschka Christian , Kraft Philip , Tacke Reinhold 
Published: May 2011

AbstractWith an odor threshold value of 0.54 ng L–1 air, (3E,5E)‐7,7‐dimethyl‐5‐tert‐butylocta‐3,5‐dien‐2‐one (1a) constitutes the most potent member of a new family of acyclic musk odorants with ionone aspects. Replacement of the quaternary carbon atoms of 1a with silicon atoms leads to the (di)sila analogues 1b (replacement of the carbon atom C‐7), 1c (replacement of the quaternary carbon atom of the 5‐tert‐butyl group), and 1d (replacement of both quaternary carbon atoms). Compounds 1b–1d were prepared in multistep syntheses, and their olfactory properties were characterized. The disila analogue 1d turned out to be the weakest compound of the series (197 ng L–1 air), with only very faint musky aspects. The 7‐sila analogue 1b was very floral, of iononeand rose character, and also had a distinct musky note (1.63 ng L–1 air). The 5‐trimethylsilyl analogue 1c was the most musky sila odorant of the series (10.6 ng L–1 air), with rosy but not ionone‐like facets. Thus, exchange of one or both tert‐butyl groups of 1a for a trimethylsilyl substituent had quite dramatic effects on the odor, and steric bulk at the carbon atom C‐5 seems to be important for creating a musk odor impression.
Synthesis of Photochromic Compounds for Aqueous Solutions and Focusable Light
Authors: Polyakova Svetlana M. , Belov Vladimir N. , Bossi Mariano L. , Hell Stefan W. 
Published: May 2011

AbstractPhotochromic compounds with improved performance in pure water have been prepared and characterized. They possess an asymmetrical and extended conjugation system with a 1,2‐bis(3‐thienyl)perfluorocyclopentene core, additional thiophene rings connected with sulfonic acid residues, as well as terminal pyrid‐4‐yl and 4‐alkoxyphenyl groups. A multistep synthetic route to a key compound with an amino group required for further derivatization has been developed. The complete photocyclization reaction of the initial “open ring” compound (with absorption maximum at 340 nm in MeOH or water) can be performed with a diode laser in pure water or aqueous buffer solutions (without added organic solvents) under irradiation at 366–375 nm, and the reverse ring‐opening reaction of the colored “closed ring” compound (λmax = 628 or 624 nm in MeOH or water) takes place under irradiation with visible green or red light (>500 nm). Building block 57, with a secondary amino group, can further be used in the synthesis of practically important, reversibly switchable, fluorescent compounds in which the fluorescent dye (donor) is attached to a photochromic unit (acceptor), and the resonant energy transfer from a donor to the colored form of an acceptor provides a reversible quenching of the fluorescence signal in aqueous solutions.
Seismic risk assessment of interdependent critical infrastructure systems: The case of European gas and electricity networks
Authors: Poljanšek Karmen , Bono Flavio , Gutiérrez Eugenio 
Published: May 2011

AbstractWe study the seismic vulnerability of the interdependent European gas and electricity transmission networks from a topological point of view, whereby the electricity network depends on the gas network through gas‐fired power plants. First, we assessed the seismic response for each independent network; then we analyzed the increased vulnerability due to their interdependency. We implemented a probabilistic reliability model that encompasses the spatial distribution of both network structures and their seismic hazard exposure using a Geographic Information System. We characterized the network interdependency using the strength of coupling of the interconnections, together with the seismic response of the independent—gas—network. We calculated the network fragility curves of the independent and dependent networks in terms of various performance measures (connectivity loss, power loss, and impact on the population) and found that the gas network is more seismically vulnerable than the electricity network. The interdependency introduces an extra vulnerability to the electricity network response that decreases with the extensiveness of the networks' damage states. Damage was also evaluated at a local level in order to identify the most vulnerable parts of the network, where it was found that the potential for the highest power loss is located in southeast Europe. Copyright © 2011 John Wiley & Sons, Ltd.
Mercury bioaccumulation, speciation, and influence on web structure in orb-weaving spiders from a forested watershed
Authors: Wyman Katherine E , Rodenhouse Nicholas L , Bank Michael S 
Published: May 2011

Abstract
Atmospheric deposition is an important source of Hg in remote terrestrial ecosystems of northeastern North America. As high-level invertebrate consumers, orb-weaving spiders (family Araneidae) are excellent subjects for studying the impact of sublethal levels of Hg on forest animals because their webs provide snapshots of behavior and neurological function. Spiders of the diadematus group of the genus Araneus were collected from the Jeffers Brook watershed in the White Mountain National Forest, New Hampshire (USA), and analyzed for Hg content. Webs were photographed and measured to test for correlations between Hg body burden and web structure. Collected spiders contained concentrations of total Hg averaging 44.7 ± 10.0 ng/g Hg (wet mass; mean ± standard deviation), with 37 ± 6% of the total Hg present in the methylmercury form. Mercury loads were likely accumulated through diet (potential prey items contained an average of 43% of the Hg load in collected spiders) and possibly web ingestion. The present study found no direct evidence that the web structure—and thus the prey-capture ability—of spiders in the study area was affected by their Hg body burden. Environ. Toxicol. Chem. 2011; 30:1873–1878. © 2011 SETAC
Health status of native fish (Percilia gillissi and Trichomycterus areolatus) downstream of the discharge of effluent from a tertiary-treated elemental chlorine-free pulp mill in Chile
Authors: Chiang Gustavo , McMaster Mark E , Urrutia Roberto , Saavedra M. Fernanda , Gavilán J. Francisco , Tucca Felipe , Barra Ricardo , Munkittrick Kelly R 
Published: May 2011

Abstract
Few data exist on the possible effects of pulp and paper effluent discharge on native fish populations in the Southern Hemisphere, relative to the research done in the Northern Hemisphere. The present research examined two native fish species (Trichomycterus areolatus and Percilia gillissi) for effects at both the molecular and individual level due to the discharge of effluent from a tertiary treated elemental chlorine-free pulp mill into a fluvial system in Central Chile over three seasons (February 2007, October 2007, January 2008). Different responses were observed between species and between sexes. There was an increase in the production of gonadal 17β-estradiol in the females of both species but a drop in 11-ketotestosterone production in P. gillissi males. Female gonadal size was increased, especially during the summer period, with corresponding increases the frequency of advanced oocyte development, and in the oocyte diameter in both species. Hepatic ethoxyresorufin-O-deethylase (EROD) activity was elevated for both species downstream of the discharge point, although overall it was higher in P. gillissi than T. areolatus. Decreases in the frequency of smaller-sized fish for both species, as well as a drop in the size of the adults downstream of the discharge point, were observed. The present study is the first evidence of endocrine disruption in native freshwater fish associated with modern pulp mills in South America. This study establishes possible links in the reproductive alterations observed at the subindividual and individual levels that could explain the changes observed at the population level. Environ. Toxicol. Chem. 2011; 30:1793–1809. © 2011 SETAC
The ultrastructure of lamellar stack astrocytes
Authors: Holen Torgeir 
Published: May 2011

AbstractAstrocytes support neurons and map out nonoverlapping domains in grey matter of the brain. The astrocytes of the glia limitans, however, do overlap. Using ultrastructural tools and immunogold histochemistry a subtype of astrocyte able to assemble large lamellar stacks was investigated at the ventral surface of the brain near the hypothalamus. Lamellar stacks were subsequently discovered also in the internal glia limitans of the epithalamus. Circular lamellar stacks containing AQP4 water channels surround neuronal processes, and might serve as osmosensors. The lamellar stacks are well‐organized and can form over 100 membrane layers between neuropil and the basal membrane, but a barrier function is not obvious from the noncontinuous character of the stacks along the glia limitans. © 2011 Wiley‐Liss, Inc.
Serum enterolactone and postmenopausal breast cancer risk by estrogen, progesterone and herceptin 2 receptor status
Authors: Zaineddin Aida Karina , Vrieling Alina , Buck Katharina , Becker Susen , Linseisen Jakob , Flesch‐Janys Dieter , Kaaks Rudolf , Chang‐Claude Jenny 
Published: May 2011

AbstractLignans are a group of estrogenic compounds present in plants. Several epidemiological studies proposed that lignans may protect against breast cancer by exerting anticarcinogenic activity. Levels of enterolactone were determined in serum samples of 1,250 cases and 2,164 controls from a large population‐based case–control study. We assessed the association between serum enterolactone and postmenopausal breast cancer risk using conditional logistic regression accounting for potential risk and confounding factors. Fractional polynomials were used to determine the function that best fitted the data. Moreover, we assessed heterogeneity by estrogen/progesterone/herceptin (ER/PR/HER2) status of the tumor. Additionally, a meta‐analysis with seven further studies addressing enterolactone concentrations and breast cancer risk was performed. Postmenopausal breast cancer risk decreased with increasing serum enterolactone levels [highest compared to lowest quintile: [odds ratio = 0.65; 95% confidence interval (CI) 0.52–0.83, ptrend = <0.0001]. A significant inverse association for ER+/PR+ as well as ER−/PR− tumors was observed, with a significantly stronger association for ER−/PR− tumors (pheterogeneity = 0.03). The association for ER−/PR− tumors did not differ by expression of HER2 (pheterogeneity = 0.3). The meta‐analysis yielded a significant reduced pooled risk estimate of: 0.66; 95% CI: 0.55–0.77) comparing the highest to the lowest quantiles of enterolactone levels. We found strong evidence for a significant inverse association between serum enterolactone and postmenopausal breast cancer risk, which was stronger for ER−PR− than for ER+PR+ tumors but not differential by further expression of HER2. The overall evidence together with other studies supports an inverse association between higher serum enterolactone levels and postmenopausal breast cancer risk.
Variations in sex hormone metabolism genes, postmenopausal hormone therapy and risk of endometrial cancer
Authors: Razavi Pedram , Lee Eunjung , Bernstein Leslie , Van Den Berg David , Horn‐Ross Pamela L. , Ursin Giske 
Published: May 2011

AbstractWe investigated whether variants in sex steroid hormone metabolism genes modify the effect of hormone therapy (HT) on endometrial cancer risk in postmenopausal non‐Hispanic white women. A nested case–control study was conducted within the California Teachers Study (CTS). We genotyped htSNPs in six genes involved in the hormone metabolism in 286 endometrial cancer cases and 488 controls. Odds ratio (OR) and 95% confidence interval (CI) were estimated for each haplotype using unconditional logistic regression, adjusting for age. The strongest interaction was observed between duration of estrogen therapy (ET) use and haplotype 1A in CYP11A1 (pinteraction = 0.0027; pinteraction = 0.010 after correcting for multiple testing within each gene). The OR for endometrial cancer per copy of haplotype 1A was 2.00 (95% CI: 1.05–3.96) for long‐term ET users and 0.90 (95% CI: 0.69–1.18) for never users. The most significant interaction with estrogen‐progestin therapy (EPT) was found for two haplotypes on CYP19A1 and EPT use (haplotype 4A, pinteraction = 0.024 and haplotype 3B, pinteraction = 0.043). However, neither this interaction, nor the ET or EPT interactions for any other genes, was statistically significant after correction for multiple testing. Variations in CYP11A1 may modify the effect of ET use on risk of postmenopausal endometrial cancer; however, larger studies are needed to explore these findings further.