bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hierarchical clustering of flow cytometry data for the study of conventional central chondrosarcoma
Authors: Diaz‐Romero Jose , Romeo Salvatore , Bovée Judith V.M.G. , Hogendoorn Pancras C.W. , Heini Paul F. , Mainil‐Varlet Pierre 
Published: May 2010

AbstractWe have investigated the use of hierarchical clustering of flow cytometry data to classify samples of conventional central chondrosarcoma, a malignant cartilage forming tumor of uncertain cellular origin, according to similarities with surface marker profiles of several known cell types. Human primary chondrosarcoma cells, articular chondrocytes, mesenchymal stem cells, fibroblasts, and a panel of tumor cell lines from chondrocytic or epithelial origin were clustered based on the expression profile of eleven surface markers. For clustering, eight hierarchical clustering algorithms, three distance metrics, as well as several approaches for data preprocessing, including multivariate outlier detection, logarithmic transformation, and z‐score normalization, were systematically evaluated. By selecting clustering approaches shown to give reproducible results for cluster recovery of known cell types, primary conventional central chondrosacoma cells could be grouped in two main clusters with distinctive marker expression signatures: one group clustering together with mesenchymal stem cells (CD49b‐high/CD10‐low/CD221‐high) and a second group clustering close to fibroblasts (CD49b‐low/CD10‐high/CD221‐low). Hierarchical clustering also revealed substantial differences between primary conventional central chondrosarcoma cells and established chondrosarcoma cell lines, with the latter not only segregating apart from primary tumor cells and normal tissue cells, but clustering together with cell lines from epithelial lineage. Our study provides a foundation for the use of hierarchical clustering applied to flow cytometry data as a powerful tool to classify samples according to marker expression patterns, which could lead to uncover new cancer subtypes. J. Cell. Physiol. 225: 601–611, 2010. © 2010 Wiley‐Liss, Inc.
PTP1B deficiency enhances liver growth during suckling by increasing the expression of insulin‐like growth factor‐I
Authors: Escrivá Fernando , González‐Rodriguez Águeda , Fernández‐Millán Elisa , Rondinone Cristina M. , Álvarez Carmen , Valverde Ángela M. 
Published: May 2010

AbstractProtein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin and tyrosine kinase growth factor signaling. We have recently demonstrated that PTP1B deficiency increases GLUT2/insulin receptor (IR) A complexes and glucose uptake in suckling, but not adult, primary hepatocytes. Herein we have investigated intrahepatic glucose utilization in 3–5 days old wild‐type and PTP1B−/− mice. PTP1B deficiency decreased glycogen, lactate, and pyruvate content in the livers from suckling mice. Conversely, the activity of glucose 6‐phosphate dehydrogenase (G6PD), the rate limiting enzyme of the pentose phosphate cycle (PPC) which provides substrates for DNA synthesis, was enhanced in the liver of PTP1B−/− animals. Liver weight, liver‐to‐body mass ratio, DNA content, and PCNA expression were increased in PTP1B−/− suckling mice compared to the wild‐type controls. At the molecular level, STAT 5B phosphorylation, IGF‐I mRNA, and protein levels as well as IGF‐IR tyrosine phosphorylation were increased in the livers of PTP1B‐deficient neonates. Unexpectedly, hepatic and serum triglycerides (TG) were increased by PTP1B deficiency, although the expression of lipogenic enzymes remained as in the wild‐type controls. However, the analysis of milk composition revealed higher TG content in lactating females lacking PTP1B. The effects of PTP1B deficiency on G6PD activity, STAT 5B/IGF‐I/IGF‐IR axis, PCNA expression and liver growth during suckling were maintained by transferring PTP1B−/− embryos (PTP1B−/−T) to a wild‐type female. Conversely, PTP1B−/−T mice did not show hepatic fat accumulation. In conclusion, the present study suggests that PTP1B plays a unique role in the control of the physiological liver development after birth. J. Cell. Physiol. 225: 214–222, 2010. © 2010 Wiley‐Liss, Inc.
Syzygium cumini leaf and seed extract mediated biosynthesis of silver nanoparticles and their characterization
Authors: Kumar Vineet , Yadav Subhash C , Yadav Sudesh Kumar 
Published: May 2010

AbstractBACKGROUND: Plant mediated synthesis of metallic nanoparticles has been studied and reported, however, to date, the biomolecules involved in the synthesis of metallic nanoparticles have not been characterized. This study was therefore undertaken to characterize the biomolecules of Syzygium cumini involved in the synthesis of silver nanoparticles.RESULTS: Synthesis kinetics and morphological characterization of silver nanoparticles (SNP) synthesized using leaf extract (LE) and seed extract (SE) as well as their polar (water) fractions from Syzygium cumini were compared. The polyphenols content and high performance liquid chromatography (HPLC) profile of different fractions revealed good correlation between size and synthesis rate of SNP. SE contains more polyphenols and biochemical constituents than LE and therefore, showed higher synthesis rate and bigger sized SNP. To analyse the nature of biomolecules involved in the synthesis of SNP, LE and SE were fractionated on a polarity basis by solvent–solvent partitioning. Only the water fractions of LE and SE showed potential for SNP synthesis. Atomic force microscopy (AFM) and scanning electron microscopy (SEM) analysis of SNP indicated that all fractions catalyze the synthesis of spherical nanoparticles. The average size of SNP synthesized by LE, leaf water fraction, SE and seed water fraction were 30, 29, 92, and 73 nm respectively.CONCLUSION: Results suggest that only highly polar soluble constituents are responsible for SNP synthesis. The size of SNP was found to be directly correlated with the amount of polyphenols as well as surfactants present in the reaction solution. Thus, the amount of polyphenols could be one of the crucial parameters determining the size and distribution of SNP. Copyright © 2010 Society of Chemical Industry
Iodide mumps: Sonographic appearance
Authors: Greco S. , Centenaro R. , Lavecchia G. , Rossi F. 
Published: May 2010

AbstractSwelling of the salivary glands occurring after injection of iodine‐based contrast agent is a rare late adverse reaction. Only a few cases in the literature illustrate such ultrasound findings. © 2010 Wiley Periodicals, Inc. J Clin Ultrasound 38:438–439, 2010
“But we can't go back”
Authors: Spiers Judith A. , Cummings Greta G. , Langenhoff Paula , Sharlow Janice , Bhatti Aslam 
Published: May 2010

AbstractIn 2004, a provincial cancer agency in Canada developed and implemented a provincewide Leadership Development Initiative (LDI) to enhance organizational leadership and relationships. Research using a quasi‐experimental survey design determined whether LDI implementation influenced the emotional health and leadership practices of LDI participants. An ethnographic approach (18 focus groups and 13 individual interviews) explored participants' perceptions of the LDI. This article presents qualitative findings that contribute to understanding the statistically significant findings of increasing levels of cynicism, emotional exhaustion, and burnout for most LDI participants. The LDI was regarded as a critical strategy for helping leaders grow and cope with change and help in changing organizational leadership culture to be more collaborative and inclusive. However, an organizational history of short‐lived, flavor‐of‐the‐month development initiatives and growing skepticism and disengagement by leaders represented in the themes of Catch‐22 and “there is no going back” contributes to understanding why these quantitative measures increased. Few studies have explored the hypothesis that real organizational development happens through a series of planned stages. In this study, leaders experienced escalating frustration because change was not seen to occur fast enough in “others” and reported that this was necessary before they would alter their own behavior. Leadership development programs in general need to reflect the reality that it takes considerable time, patience, and effort to effect fundamental change in leadership culture.
Enabling or “real” power and influence in leadership
Authors: Drew Glenys M. 
Published: May 2010

AbstractOn the theme of personal development, this conceptual article aims to provoke thought about power and influence in leadership by means of a short excursion into character depictions in J.R.R. Tolkien's The Lord of the Rings (1966). It is said of mythopoeic literature, the genre of Tolkien's work, that the very simplicity of the lens “pares away distractions,” “opens the way to unexpected connections, … [and] draws attention to alternative modes of being and thinking” (Greene, 1994, p. 457). Taking the liberty of perceived applicability of Tolkien's literary genius to motifs on leadership, this article provokes thinking on what constitutes “real” power and influence in leadership. It is contended that demonstrating real power and influence in leadership lies not in coercive tactics of wielding power over others but in withholding usurping power to work with and enable others to achieve worthwhile ends. Three suggested markers of enabling or real power and influence in leadership are explored. Each one contains an element of paradox. The proposed markers suggest, in turn, that enabling or real power and influence does not usurp but serves, that it sublimates self‐interest for the interests of others and the intended goal, and that it positions for growth for the self and others and fosters true engagement in leadership. The article offers some empirical evidence as to the efficacy of the proposed markers for effective leadership and suggests a further research strategy to test the proposed markers empirically.
Higher education in the global knowledge economy
Authors: Molina‐Ray Caroline 
Published: May 2010

AbstractTechnology and globalization have the potential to make higher education more affordable and accessible. In practice, however, rising costs limit educational access, and competition threatens the sustainability of many colleges and universities (Grummon, 2009). With the relevance of traditional curricula in question and the demand for alternate delivery methods expanding, many higher learning institutions face a challenge to reinvent themselves (Barnatt, 2008; Grummon, 2009; Lee, Brennan, & Green, 2009).We asked four higher education leaders from demographically and structurally diverse institutions to address the question, “How will colleges and universities serve the global knowledge economy in the coming decades?” Our respondents represent perspectives from multiple educational paradigms—public and private, local and international, for‐profit and nonprofit, brick‐and‐mortar and online.George Mihel, president of Sauk Valley Community College in Illinois, offers a position paper on the need to transform some of higher education’s deep‐rooted institutional traditions. George Miller, chancellor of American InterContinental University, teams with Caroline Molina‐Ray, a University of Phoenix faculty member, to address how higher education can foster both technological competency and critically reflexive thinking. Naana J. S. Opoku‐Agyemang, vice chancellor of the University of Cape Coast in Ghana, offers insight into the unique challenges and accomplishments of higher education in Africa. Finally, Vicki T. Purslow, associate dean of the College of Arts and Sciences at Southern Oregon University, and Christine Cook Florence, a higher education marketing consultant, present a commentary synthesizing the symposium contributions and issuing a call to action for higher education leaders. Together, these diverse perspectives offer a glimpse into the higher education of the future.
Resolving the Holocene alluvial record in southeastern Australia using luminescence and radiocarbon techniques
Authors: Cheetham Michael D. , Keene Annabelle F. , Erskine Wayne D. , Bush Richard T. , Fitzsimmons Kathryn , Jacobsen Geraldine E. , Fallon Stewart J. 
Published: May 2010

AbstractA previous assessment of radiocarbon (14C) dates from alluvial units in southeastern Australia revealed a gap in the geochronological record that coincides with the Holocene climatic optimum. This gap in the alluvial record can be further refined using optically stimulated luminescence (OSL). The chronology of Holocene river terraces on Widden Brook, a sandy alluvial stream in southeastern Australia, was established using14C and OSL techniques. Combined use of these independent techniques allows for a more rigorous assessment of the alluvial record. The robust chronology, consisting of 3814C and 11 OSL samples, permitted identification of significant depositional variation within the catchment, resulting from localised geomorphic processes. The three terrace sequences identified yielded distinct chronologies, suggesting alluvial deposition at different times. The sequences exhibited a continuous chronology, which indicated continuous deposition throughout the Holocene. The chronology of terrace sequences within this catchment suggests that terrace formation can be attributed to localised geomorphic processes rather than climatic forcing. Copyright © 2010 John Wiley & Sons, Ltd.
Single‐molecule surface‐enhanced Raman scattering of fullerene C60
Authors: Luo Zhixun , Loo Boon H. , Peng Aidong , Ma Ying , Fu Hongbing , Yao Jiannian 
Published: May 2010

AbstractWe achieved single‐molecule surface‐enhanced Raman scattering (SM‐SERS) spectra from ultralow concentrations (10−15 M) of fullerene C60 on uniformly assembled Au nanoparticles. It was found that resonant excitation at 785 nm is a powerful tool to probe SM‐SERS in this system. The appearance of additional bands and splitting of some vibrational modes were observed because of the symmetry reduction of the adsorbed molecule and a relaxation in the surface selection rules. Time‐evolved spectral fluctuation and ‘hot spot’ dependence in the SM‐SERS spectra were demonstrated to result from the single‐molecule Raman behavior of the spherical C60 on Au nanoparticles. Copyright © 2010 John Wiley & Sons, Ltd.
Aspirin and compression devices versus low‐molecular‐weight heparin and PCD for VTE prophylaxis in orthopedic oncology patients
Authors: Patel Anay R. , Crist Martha K. , Nemitz Jason , Mayerson Joel L. 
Published: May 2010

AbstractBackgroundDeep venous thrombosis (DVT) and pulmonary embolism (PE) are possible sources of morbidity and mortality in patients with musculoskeletal neoplasms (MSN).ObjectiveTo compare the efficacy of aspirin (ASA) and pneumatic compression devices (PCD) to low‐molecular‐weight heparin (LMWH) and PCD in patients undergoing orthopedic procedures for MSN of the pelvis or lower extremity.MethodsOf 348 patients who met the study criteria, 195 were treated with ASA/PCD and 153 with LMWH/PCD. There were 18 DVT including 8 in ASA/PCD group and 10 in LMWH/PCD group. There were four PEs, all in the LMWH/PCD group.ResultsWe found no significant difference in DVT rate between ASA/PCD and LMWH/PCD when used for prophylaxis against thromboembolic complications. Our analysis shows that procedures of the thigh, soft tissue resections, and malignant disease were more often managed with ASA/PCD while joint arthroplasty, procedures of the hip/pelvis, and metastatic disease were more often managed with LMWH/PCD.ConclusionDVT prophylaxis in orthopedic oncology remains a complex topic in which physicians must balance the risks of thromboembolic disease against the risks of post‐operative complications. J. Surg. Oncol. 2010;102:276–281. © 2010 Wiley‐Liss, Inc.
Monitoring land use change in the Çeşme coastal zone, Turkey using aerial photographs and satellite imaging
Authors: Hepcan Ç. C. , Turan İ. A. , Özkan M. B. 
Published: May 2010

AbstractHumans change the landscapes and especially the coastal zones for their requirements. The aim of the study was to analyse land use changes in the Çeşme coastal zone, Turkey, during a 48‐year period (1957–2005) using remote sensing and GIS. In this study, land use changes in the Çeşme coastal zone were analysed using the four sets of land use maps derived from aerial photographs and classified satellite image taken in the years 1957, 1976, 1995 and 2005. Post‐classification algorithm change detection was applied to observe land use changes during three time periods: Period 1 (1957–1976), Period 2 (1976–1995) and Period 3 (1995–2005). The results showed that natural land cover and agricultural lands decreased and built‐up area increased throughout the study area during the 48‐year period between 1957 and 2005. Furthermore, land use change was successively increased in Period 1, Period 3 and Period 2. Copyright © 2010 John Wiley & Sons, Ltd.
Successful outcomes following living donor liver transplantation for portopulmonary hypertension
Authors: Bandara Mahesh , Gordon Fredric D. , Sarwar Akmal , Knauft Elizabeth M. , Pomfret Elizabeth A. , Freeman Richard B. , Wirth Joel A. 
Published: May 2010

Abstract
Pulmonary arterial hypertension (PAH) associated with portal hypertension [portopulmonary hypertension (PPHTN)] occurs in 2% to 10% of patients with advanced liver disease and carries a very poor prognosis without treatment. Most hepatic transplantation centers consider moderate to severe PPHTN to be a contraindication to liver transplantation because of the high rate of perioperative complications. We present 3 patients with PPHTN who were managed with intravenous prostacyclin therapy followed by living donor liver transplantation (LDLT). These individuals demonstrated subsequent resolution of their pulmonary hypertension and were weaned off all PAH-specific medical therapy. We present their demographics, clinical courses, and hemodynamics. We discuss the potential indications for LDLT and risks with respect to this patient population. Limitations of the Model for End-Stage Liver Disease scoring system and outcome data for this patient population are reviewed. Future studies should be directed toward better defining indications for LDLT in patients with PPHTN, improving medicosurgical management, and assessing long-term outcomes. Liver Transpl 16:983-989, 2010. © 2010 AASLD.
A Galois correspondence for countable short recursively saturated models of PA
Authors: Shochat Erez 
Published: May 2010

AbstractIn this paper we investigate the properties of automorphism groups of countable short recursively saturated models of arithmetic. In particular, we show that Kaye's Theorem concerning the closed normal subgroups of automorphism groups of countable recursively saturated models of arithmetic applies to automorphism groups of countable short recursively saturated models as well. That is, the closed normal subgroups of the automorphism group of a countable short recursively saturated model of PA are exactly the stabilizers of the invariant cuts of the model which are closed under exponentiation. This Galois correspondence is used to show that there are countable short recursively saturated models of arithmetic whose automorphism groups are not isomorphic as topological groups. Moreover, we show that the automorphism groups of countable short arithmetically saturated models of PA are not topologically isomorphic to the automorphism groups of countable short recursively saturated models of PA which are not short arithmetically saturated (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A note on stability spectrum of generic structures
Authors: Anbo Yuki , Ikeda Koichiro 
Published: May 2010

AbstractWe show that if a class K of finite relational structures is closed under quasi‐substructures, then there is no saturated K‐generic structure that is superstable but not ω ‐stable (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Some observations on the substructure lattice of a Δ1 ultrapower
Authors: McLaughlin Thomas G. 
Published: May 2010

AbstractGiven a (nontrivial) Δ1 ultrapower ℱ/𝒰, let ℒ︁U denote the set of all Π2‐correct substructures of ℱ/𝒰; i.e., ℒ︁U is the collection of all those subsets of |ℱ/𝒰| that are closed under computable (in the sense of ℱ/𝒰) functions. Defining in the obvious way the lattice ℒ︁(ℱ/𝒰)) with domain ℒ︁U, we obtain some preliminary results about lattice embeddings into – or realization as – an ℒ︁(ℱ/𝒰). The basis for these results, as far as we take the matter, consists of (1) the well‐known class of (non‐trivial) minimal ℱ/𝒰's, which function as atoms, and (2) the class of minimalfree ℱ/𝒰's, to whose nonemptiness a substantial section of the paper is devoted. It is shown that an infinite, convergent monotone sequence together with its limit point is embeddable in an ℒ︁(ℱ/𝒰), and that the initial segment lattices {0, 1,…, n } are not just embeddable in (as is trivial), but in fact realizable as, lattices ℒ︁(ℱ/𝒰). Finally, the diamond is (easily) embeddable; and if it is not realizable, then either the 1 ‐ 3 ‐ 1 lattice or the pentagon is at least embeddable (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Boolean products of R0‐algebras
Authors: Zhou Xiangnan , Li Qingguo 
Published: May 2010

AbstractIn this paper, the (weak) Boolean representation of R0‐algebras are investigated. In particular, we show that directly indecomposable R0‐algebras are equivalent to local R0‐algebras and any nontrivial R0‐algebra is representable as a weak Boolean product of local R0‐algebras (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Abelian groups and quadratic residues in weak arithmetic
Authors: Jeřábek Emil 
Published: May 2010

AbstractWe investigate the provability of some properties of abelian groups and quadratic residues in variants of bounded arithmetic. Specifically, we show that the structure theorem for finite abelian groups is provable in S22 + iWPHP(Σ1b), and use it to derive Fermat's little theorem and Euler's criterion for the Legendre symbol in S22 + iWPHP(PV) extended by the pigeonhole principle PHP(PV). We prove the quadratic reciprocity theorem (including the supplementary laws) in the arithmetic theories T20 + Count2(PV) and I Δ0 + Count2(Δ0) with modulo‐2 counting principles (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Zariski‐type topology for implication algebras
Authors: Abad Manuel , Castaño Diego , Díaz Varela José P. 
Published: May 2010

AbstractIn this work we provide a new topological representation for implication algebras in such a way that its one‐point compactification is the topological space given in [1]. Some applications are given thereof (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Lévy processes on a first order model
Authors: Ng Siu‐Ah 
Published: May 2010

AbstractThe classical notion of Lévy process is generalized to one that takes as its values probabilities on a first or‐der model equipped with a commutative semigroup. This is achieved by applying a convolution product on definable probabilities and the infinite divisibility with respect to it (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A discrete representation of free MV‐algebras
Authors: Di Nola Antonio , Grigolia Revaz , Spada Luca 
Published: May 2010

AbstractWe prove that the m ‐generated free MV‐algebra is isomorphic to a quotient of the disjoint union of all the m ‐generated free MV(n)‐algebras. Such a quotient can be seen as the direct limit of a system consisting of all free MV(n)‐algebras and special maps between them as morphisms (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)