bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frostbite injuries to the upper aerodigestive tract sustained from inhaled nitrous oxide
Authors: Gao Junru 
Published: May 2024

Abstract

Background
Nitrous oxide (N2O) has been in industrial and recreational use since the 18th century and is commonly perceived as a safe substance. Despite its increasing uptake, there is a lack of data on N2O-related harm. This article explores the misuse of N2O associated with various complications, with a focus on frostbite as a novel phenomenon. We aimed to review the existing body of literature and describe the epidemiology, presentation, pathophysiology, and management of patients with N2O-related frostbite injuries in the upper aerodigestive tract.

Methods
A literature search was conducted across PubMed, MEDLINE and Embase databases, focusing on English language articles related to N2O use patterns, associated injuries, pathophysiology, investigations, and management.

Results
The search yielded 122 results, of which fifteen case reports and case series were included in the study. There are 54 total cases included in the analysis. There is an equal distribution of males and females among a young population with a median age of 27.5 years. Presentations of skin and mucosal injuries across different anatomical sites as well as their management approaches are described.

Conclusions
The pathophysiology of frostbite involves both direct and indirect effects, leading to tissue ischaemia, inflammation, and immune responses. Complications, including airway obstruction, underscore the severity of N2O-related injuries. Management strategies include securing the airway, surgical debridement, and pharmacological interventions such as prophylactic corticosteroids and antibiotics. N2O is a documented causative agent of frostbite injuries. Awareness of its rising prevalence and potential complications is key in the treatment of patients with complications sustained from the use of N2O.

Level of evidence
Not ratable
Assessment of cerebral drug occupancy in humans using a single PET-scan: A [11C]UCB-J PET study
Authors: Marstrand-Joergensen Maja R. , Laurell Gjertrud L. , Herrmann Susan , Nasser Arafat , Johansen Annette , Lund Anton , Andersen Thomas L. , Knudsen Gitte M. , Pinborg Lars H. 
Published: May 2024

Abstract
Purpose
Here, we evaluate a PET displacement model with a Single-step and Numerical solution in healthy individuals using the synaptic vesicle glycoprotein (SV2A) PET-tracer [11C]UCB-J and the anti-seizure medication levetiracetam (LEV). We aimed to (1) validate the displacement model by comparing the brain LEV-SV2A occupancy from a single PET scan with the occupancy derived from two PET scans and the Lassen plot and (2) determine the plasma LEV concentration-SV2A occupancy curve in healthy individuals.

Methods
Eleven healthy individuals (five females, mean age 35.5 [range: 25–47] years) underwent two 120-min [11C]UCB-J PET scans where an LEV dose (5–30 mg/kg) was administered intravenously halfway through the first PET scan to partially displace radioligand binding to SV2A. Five individuals were scanned twice on the same day; the remaining six were scanned once on two separate days, receiving two identical LEV doses. Arterial blood samples were acquired to determine the arterial input function and plasma LEV concentrations. Using the displacement model, the SV2A-LEV target engagement was calculated and compared with the Lassen plot method. The resulting data were fitted with a single-site binding model.

Results
SV2A occupancies and VND estimates derived from the displacement model were not significantly different from the Lassen plot (p = 0.55 and 0.13, respectively). The coefficient of variation was 14.6% vs. 17.3% for the Numerical and the Single-step solution in Bland-Altman comparisons with the Lassen plot. The average half maximal inhibitory concentration (IC50), as estimated from the area under the curve of the plasma LEV concentration, was 12.5 µg/mL (95% CI: 5–25) for the Single-Step solution, 11.8 µg/mL (95% CI: 4–25) for the Numerical solution, and 6.3 µg/mL (95% CI: 0.08-21) for the Lassen plot. Constraining Emax to 100% did not significantly improve model fits.

Conclusion
Plasma LEV concentration vs. SV2A occupancy can be determined in humans using a single PET scan displacement model. The average concentration of the three computed IC50 values ranges between 6.3 and 12.5 µg/mL. The next step is to use the displacement model to evaluate LEV occupancy and corresponding plasma concentrations in relation to treatment efficacy.

Clinical trial registration
NCT05450822. Retrospectively registered 5 July 2022 https://clinicaltrials.gov/ct2/results? term=NCT05450822&Search=Search.
Declining freshwater habitats in Greenland may shift diets of the ubiquitous wolf spider Pardosa glacialis
Authors: Bliska Hanna M. , DeSiervo Melissa H. , Virginia Ross A. , Ayres Matthew P. , Culler Lauren E. 
Published: May 2024

AbstractFreshwater habitats in Arctic landscapes provide essential food resources to predaceous terrestrial fauna. However, climate change threatens the continuation of aquatic resources as increased temperatures prompt widespread drying. We investigated how declines in surface waters in the Arctic may have implications for the diets of the wolf spider Pardosa glacialis (Araneae: Lycosidae), an abundant top predator in western Greenland known to consume both aquatic and terrestrial prey. We estimated the abundance of ground-dwelling prey taxa near and far from shallow ponds to compare resource availability for P. glacialis. We also measured the stable isotopes ratios of carbon and nitrogen of potential prey taxa and used linear mixing models to estimate the relative proportions of aquatic and terrestrial prey in the diets of P. glacialis collected near ponds versus drier, upland locations. Overall, near ponds there was a 3.7 times greater abundance of ground-dwelling organisms compared to locations far from ponds. Near ponds, depleted δ13C values of P. glacialis compared to the upland locations were explained by the consumption of aquatic insects, which were relatively depleted in 13C compared to terrestrial ground-dwelling and canopy taxa. Our linear mixing model indicated that the mean relative contribution of aquatic taxa to the diets of P. glacialis at pond locations was ~ 23% versus ~ 0% at upland locations, though these results were accompanied by significant uncertainty. Our results emphasize the importance of Arctic ponds in providing habitat to potential prey of terrestrial predators. We highlight how climate change, and the continued disappearance of aquatic habitats, could disrupt critical linkages between aquatic insects and terrestrial predators.
Exciplex-driven blue OLEDs: unlocking multifunctionality applications
Authors: Weber Dominik , Morgenstern Annika , Beer Daniel , Zahn Dietrich R. T. , Deibel Carsten , Salvan Georgeta , Schondelmaier Daniel 
Published: May 2024

AbstractWe present the development of multifunctional blue-emission organic light-emitting diodes (OLEDs) using TADF-exciplex materials. These OLEDs exhibit sensitivity to external stimuli and achieve a maximum external quantum efficiency (EQE) of 11.6% through partly liquid processing. This technique allows for large-scale production on arbitrary geometries.The potential multifunctionality of the devices arises from their response to low external magnetic fields (up to 100 mT) with an efficiency up to 2.5% for magnetoconductance, while maximum magneto-electroluminescence effects of 4.1% were detected. We investigated novel aspects, including the utilization of two organic materials without further doping and the investigation of the impact of 2,2ʹ,2″-(1,3,5-Benzinetriyl)-tris(1-phenyl-1-H-benzimidazole) (TPBi) processing in liquid and vapor form. The insights gained provide a fundamental understanding regarding the applicability of exciplex (EX) materials for fully solution-processed OLEDs through a deliberate omission of doping. Our work represents a significant advancement on the path towards multifunctional OLED technology, with potential applications in cost-efficient, scalable organic full-color displays and advanced sensing system.
Do alpha blockers reduce the risk of urinary retention post-transperineal prostate biopsy? A systematic narrative review
Authors: Alhamdani Zein , Poppenbeek Samuel , Bolton Damien , Wong Lih-Ming , Sethi Kapil 
Published: May 2024

Abstract
Background
Transperineal Prostate Biopsy (TPB) is a commonly used technique for the diagnosis of prostate cancer due to growing concerns related to infectious complications associated with transrectal ultrasound-guided prostate biopsy (TRUSB). TPB is associated with an infective complication rate of near zero, however, acute urinary retention (AUR) remains the leading complication causing morbidity. Previously in TRUSB, there was weak evidence that alpha-blockers reduce AUR rates, and their usage has been extrapolated to clinical practice with TPB. This review aims to explore if there is an evidence base for using alpha-blockers to prevent AUR following TPB.

Methods
A systematic approach was used to search Ovid Medline and Embase using keywords related to “Transperineal” and “Retention”. Articles were then screened by applying inclusion and exclusion criteria to find studies that compared alpha-blocker recipients to no alpha-blocker use in the perioperative period and the subsequent effect on AUR in TPB.

Results
361 records were identified in the initial search to produce 5 studies included in the final review. No randomised controlled trials (RCTs) were identified. One observational study showed a reduction in AUR rate from 12.5% to 5.3% with a single dose of tamsulosin. A previous systematic review of complications associated with prostate biopsy concluded there may be a potential benefit to alpha-blockers given in the TPB perioperative period. Three observational studies demonstrated a harmful effect related to alpha-blocker use; however, this was well explained by their clear limitations.

Conclusion
Based on this review and the extrapolation from TRUSB data, perioperative alpha-blockers may offer some weak benefits in preventing AUR following TPB. However, there is significant scope and need for an RCT to further develop the evidence base further given the significant gap in the literature and lack of a standard alpha blocker protocol in TPB.
Diffusion-driven fed-batch fermentation in perforated ring flasks
Authors: Lüchtrath Clara , Lamping Felix , Hansen Sven , Finger Maurice , Magnus Jørgen , Büchs Jochen 
Published: May 2024

Abstract
Purpose
Simultaneous membrane-based feeding and monitoring of the oxygen transfer rate shall be introduced to the newly established perforated ring flask, which consists of a cylindrical glass flask with an additional perforated inner glass ring, for rapid bioprocess development.

Methods
A 3D-printed adapter was constructed to enable monitoring of the oxygen transfer rate in the perforated ring flasks. Escherichia coli experiments in batch were performed to validate the adapter. Fed-batch experiments with different diffusion rates and feed solutions were performed.

Results
The adapter and the performed experiments allowed a direct comparison of the perforated ring flasks with Erlenmeyer flasks. In batch cultivations, maximum oxygen transfer capacities of 80 mmol L−1 h−1 were reached with perforated ring flasks, corresponding to a 3.5 times higher capacity than in Erlenmeyer flasks. Fed-batch experiments with a feed reservoir concentration of 500 g glucose L−1 were successfully conducted. Based on the oxygen transfer rate, an ammonium limitation could be observed. By adding 40 g ammonium sulfate L−1 to the feed reservoir, the limitation could be prevented.

Conclusion
The membrane-based feeding, an online monitoring technique, and the perforated ring flask were successfully combined and offer a new and promising tool for screening and process development in biotechnology.
Development of the Parent-to-Infant Bonding Scale: Validation in Swedish Mothers and Fathers in Community and Clinical Contexts
Authors: Lindeberg Sara , Tedgård Eva , Kerstis Birgitta , Tedgård Ulf , Taylor Alyx , Jönsson Peter 
Published: May 2024

AbstractValid measurement instruments are needed to investigate the impact of parental bonding on child health development. The aim was to develop and validate a self-report questionnaire, the Parent-to-Infant Bonding Scale (PIBS) to measure bonding in both mothers and fathers. Internal consistency and construct validity were analysed using data from Swedish parents from both clinical (N = 182), and community (N = 122) population samples. Overall, good or acceptable internal consistency of the PIBS appeared. Convergent validity (against the Postpartum Bonding Questionnaire, analysed in the clinical sample) and discriminant validity (against the mental health constructs of depressive symptoms and anxiety) were demonstrated. The results support the PIBS as a measure of maternal and paternal bonding in community and clinical populations. Assessments of criterion validity in these populations are desirable. The similarities in PIBS measurement properties between the parent groups suggest its usefulness for comparisons between mothers and fathers, and for future investigations of unique and interactive impacts of maternal and paternal bonding on child outcomes using community and clinical cohorts.
The long-term implications of destruction during the Second World War on private wealth in Germany
Authors: Halbmeier Christoph , Schröder Carsten 
Published: May 2024

AbstractBy the end of the Second World War, an estimated 20% of the West German housing stock had been destroyed. Building on a theoretical life-cycle model, this paper examines the persistent consequences of the war for individual wealth across generations. As our empirical basis, we link a unique historical dataset on the levels of wartime destruction in 1739 West German cities with micro data on individual wealth at the beginning of the twenty-first century from the German Socio-Economic Panel. Among individuals born in cities or villages that were badly damaged during the Second World War, wealth is still about 10% lower today. Similarly, the destruction of parental birthplace has significant negative implications for the wealth of their descendants. These negative implications are robust after controlling for a rich set of pre-war regional and city-level control variables. In complementary empirical exercises, we study potential channels such as inheritances, health, and education, through which the wartime destruction could have affected wealth accumulation across generations.
Regulation by Design: Features, Practices, Limitations, and Governance Implications
Authors: Prifti Kostina , Morley Jessica , Novelli Claudio , Floridi Luciano 
Published: May 2024

AbstractRegulation by design (RBD) is a growing research field that explores, develops, and criticises the regulative function of design. In this article, we provide a qualitative thematic synthesis of the existing literature. The aim is to explore and analyse RBD’s core features, practices, limitations, and related governance implications. To fulfil this aim, we examine the extant literature on RBD in the context of digital technologies. We start by identifying and structuring the core features of RBD, namely the goals, regulators, regulatees, methods, and technologies. Building on that structure, we distinguish among three types of RBD practices: compliance by design, value creation by design, and optimisation by design. We then explore the challenges and limitations of RBD practices, which stem from risks associated with compliance by design, contextual limitations, or methodological uncertainty. Finally, we examine the governance implications of RBD and outline possible future directions of the research field and its practices.
Enhancing Argumentation and Decision-Making of Preservice Early Childhood Education Teachers Through Role-Playing on Animal Experimentation
Authors: Vicente Juan José , Franco-Mariscal Antonio Joaquín , Oliva José María 
Published: May 2024

AbstractThis study explores the socio-scientific issue of the relevance of animal experimentation using a role-playing game to develop argumentation and decision-making skills as key components of critical thinking. The activity was conducted with two cohorts, each consisting of 30 pre-service early childhood education teachers at the University of Málaga (Málaga, Spain). The study analyzes the arguments provided by the participants to justify their decisions and perceptions on the issue before and after engaging in the role-playing. The findings reveal a progression of participants from the initial rejection of animal experimentation to recognizing its imperative role in shaping scientific knowledge. Additionally, an enhancement in the understanding of rational aspects of the issue is detected, as observed through the evolution of the types of arguments employed in justifications before and after the intervention. Furthermore, emotionally charged arguments related to ethical and moral aspects of the issue are also observed.
IT-Sicherheitsmaßnahmen beim Versand von E-Mails im Geschäftsverkehr
Authors: Hofmann Sebastian 
Published: May 2024

ZusammenfassungFür den Fall, dass sich ein deliktisch handelnder Dritter Zugriff auf den E-Mail-Account verschafft
und mehrere Rechnungen mit verfälschten Bankinformationen versendet, lehnt das OLG Karlsruhe einen
Schadenersatzanspruch eines im guten Glauben Leistenden ab. Dies gilt, wenn weder Pflichtverletzung noch
Kausalität für den eingetretenen Schaden nachgewiesen werden können. Das OLG Karlsruhe hat
einen Beweis ersten Anscheins für fehlende IT-Sicherheitsmaßnahmen, die deliktisches Handeln eines
Dritten ermöglicht haben, verneint. 1 In diesem Beitrag soll mithilfe eines dem Fall nachgestellten
Beispiels gezeigt werden, welche technischen Hintergründe für die Annahme eines Anscheinsbeweises
sprechen und wie diese in der Beweiswürdigung Berücksichtigung finden können.
Use of mixed gas pneumoperitoneum during minimally invasive surgery: a systematic review of human and mouse modelled laparoscopic interventions
Authors: Chen Leon , Dasgupta Prokar , Vasdev Nikhil 
Published: May 2024

AbstractThe formation of pneumoperitoneum involves the process of inflating the peritoneal cavity during laparoscopic and typically uses CO2 as the insufflation gas. This review aims to identify ideal gas mixtures for establishing the pneumoperitoneum with animal and human studies undertaken up to the writing of this review. A systematic search of PubMed, OVID, and clinicaltrials.gov was performed to identify studies on the utilisation of mixed gases in laparoscopic surgery, including non-randomised/randomised trials, animal and human studies, and studies with inflating pressures between 12 and 16 mmHg. ROBINS-I and RoB2 tool was used to assess the risk of bias. A narrative synthesis of results was performed due to the heterogeneity of the studies. 5 studies from the database search and 5 studies from citation search comprising 128 animal subjects and 61 human patients were found. These studies collated results based on adhesion formation (6 studies), pain scores (2 studies) and other outcomes, with results favouring the use of carbon dioxide + 10% nitrous oxide + 4% oxygen. This has shown a significant reduction in adhesion formation, pain scores and inflammation. The use of this gas mixture provides promising results for future practice. Several of the studies available require larger sample sizes to develop a more definitive answer on the effects of different gas mixtures. Furthermore, the number of confounding factors in randomised trials should be reduced so that each component of the current suggested gas mixture can be tested for safety and efficacy.
Tribo-Corrosion Control with Molecules of Bio-Origin: Experimental Studies and Theoretical Insights
Authors: Mulky Lavanya , Rao Padmalatha 
Published: May 2024

AbstractTribo corrosion control of 6061 aluminum alloy was done by using naturally available Boswellia serrata (BWS) extract as green inhibitor. Studies were done in artificial sea water slurry containing 0.03% sand particles via a submerged jet impingement technique. Electrochemical studies were the majour techniques adopted for corrosion rate measurement in the absence and in the presence of inhibitor. Investigation was done at different flow rates and at different temperatures. Detailed surface study was done for sand particles before and after impingement using scanning electron microscope. Surface morphology of aluminum sample was done before and after the addition of inhibitor. For a given flowrate inhibition efficiency decreased with increase in temperature. This suggested the possibility of physical adsorption. Results were fitted into suitable adsorption isotherm. Mechanism of adsorption was supported and substantiated by quantum chemical calculations using Density Functional Theory (DFT). The best corrosion–erosion resistance was obtained at a concentration of 1000 ppm Boswellia serrata at 303 K under 4 L min−1. DFT studies supported the adsorption mechanism of the inhibitor on the surface of metal under tribological conditions. The outcome of this work will help in research that is focused on development on green inhibitors for corrosion inhibition under dynamic multi flow conditions.
Uncertainty-aware non-invasive patient–ventilator asynchrony detection using latent Gaussian mixture generative classifier with noisy label correction
Authors: Wang Chenyang , Luo Ling , Aickelin Uwe , Berlowitz David J. , Howard Mark E. 
Published: May 2024

AbstractPatient–ventilator asynchrony (PVA) refers to instances where a mechanical ventilator’s cycles are desynchronised from the patient’s breathing efforts, and may result in patient discomfort and potential ineffective ventilation. Typically, they are identified with constant monitoring by trained clinicians. Such expertise is often limited; therefore, it is desirable to automate PVA detection with machine learning methods. However, there are three major challenges to applying machine learning to the problem: data collected from non-invasive ventilation are often noisy, there exists high variability between patients or between setting changes, and manual annotations of PVA events are not always consistent. To produce meaningful inference from such noisy data, a model needs to not only provide a measure of uncertainty, but also take into account potential inconsistencies in the training signal it is based on. In this work, we propose a conditional latent Gaussian mixture generative classifier with noisy label correction, which is capable of capturing variations within and between classes, providing well-calibrated class probabilities, detecting unlikely input instances that deviates from training data, while also taking into account possible mislabelling of event classes. We show that our model is able to match the performance of a well-tuned gradient boosting classifier, but also produce better calibrated predictions and smaller performance variability between patients.