bluuebunny/crossref_metadata_2025_split huggingface dataset:
Movement of adult temperate reef fishes off the west coast of North America
Authors: Freiwald Jan 
Published: July 2012

Movement of reef fishes has important consequences for the demography, spatial structure, and connectivity of their populations and their conservation and management. I synthesized and analyzed the available data on the movement of adult temperate reef fishes along the west coast of North America to summarize our current knowledge and identify future research needs. For 80% of analyzed species, the 75th percentile movement distance was less than 1.5 km. Movement distances of examined species are characterized by positively skewed frequency distributions and discrete movement ranges rather than unbounded diffusive or directional movement. There is no relationship between species body size and movement distance, but shallower living species move much shorter distances than deeper dwelling reef fishes. Such limited movement suggests that ecological neighborhoods of adult individuals are small, and finite movement ranges will have important consequences for understanding and modeling population connectivity in ecological and management contexts. Future research should focus on effects of habitat heterogeneity and population parameters on movement to investigate variability in movement patterns and its consequences for species’ ecology and management.
Might Cigarettes Be a “Smoking Gun” to Reduce Taxane Myelotoxicity?
Authors: Lewis Lionel D. , Ratain Mark J. 
Published: August 2012

Abstract
de Graan and colleagues report a retrospective study of the effects of cigarette smoking on taxane pharmacokinetics and myelosuppression. There was no difference in taxane pharmacokinetic clearance between smokers and nonsmokers. Further prospective studies of the effects of cigarette smoking on myelosuppression would be of interest. Clin Cancer Res; 18(16); 4219–21. ©2012 AACR.
The Precipitation Characteristics of ISCCP Tropical Weather States
Authors: Lee Dongmin , Oreopoulos Lazaros , Huffman George J. , Rossow William B. , Kang In-Sik 
Published: August 2012

Abstract
The authors examine the daytime precipitation characteristics of the International Satellite Cloud Climatology Project (ISCCP) weather states in the extended tropics (35°S–35°N) for a 10-yr period. The main precipitation dataset used is the Tropical Rainfall Measuring Mission (TRMM) Multisatellite Precipitation Analysis operational product 3B42 dataset, but Global Precipitation Climatology Project daily data are also used for comparison. It is found that the most convectively active ISCCP weather state (WS1), despite an occurrence frequency below 10%, is the most dominant state with regard to surface precipitation, producing both the largest mean precipitation rates when present and the largest percent contribution to the total precipitation of the tropics; yet, even this weather state appears to not precipitate about half the time, although this may be to some extent an artifact of detection and spatiotemporal matching limitations of the precipitation dataset. WS1 exhibits a modest annual cycle of the domain-average precipitation rate, but notable seasonal shifts in its geographic distribution. The precipitation rates of the other weather states appear to be stronger when occurring before or after WS1. The precipitation rates of the various weather states are different between ocean and land, with WS1 producing higher daytime rates on average over ocean than land, likely because of the larger size and more persistent nature of oceanic WS1s. The results of this study, in addition to advancing the understanding of tropical hydrology, can serve as higher-order diagnostics for evaluating the realism of tropical precipitation distributions in large-scale models.
Implications of Parameter Uncertainty on Soil Moisture Drought Analysis in Germany
Authors: Samaniego Luis , Kumar Rohini , Zink Matthias 
Published: August 2012

Abstract
Simulated soil moisture is increasingly used to characterize agricultural droughts but its parametric uncertainty, which essentially affects all hydrological fluxes and state variables, is rarely considered for identifying major drought events. In this study, a high-resolution, 200-member ensemble of land surface hydrology simulations obtained with the mesoscale Hydrologic Model is used to investigate the effects of the parametric uncertainty on drought statistics such as duration, extension, and severity. Simulated daily soil moisture fields over Germany at the spatial resolution of 4 × 4 km2 from 1950 to 2010 are used to derive a hydrologically consistent soil moisture index (SMI) representing the monthly soil water quantile at every grid cell. This index allows a quantification of major drought events in Germany. Results of this study indicated that the large parametric uncertainty inherent to the model did not allow discriminating major drought events without a significant classification error. The parametric uncertainty of simulated soil moisture exhibited a strong spatiotemporal variability, which significantly affects all derived drought statistics. Drought statistics of events occurring in summer with at most 6 months duration were found to be more uncertain than those occurring in winter. Based on the ensemble drought statistics, the event from 1971 to 1974 appeared to have a 67% probability of being the longest and most severe drought event since 1950. Results of this study emphasize the importance of accounting for the parametric uncertainty for identifying benchmark drought events as well as the fact that using a single model simulation would very likely lead to inconclusive results.
Seasonal and Interannual Modulation of the Eddy Kinetic Energy in the Caribbean Sea
Authors: Jouanno Julien , Sheinbaum Julio , Barnier Bernard , Molines Jean Marc , Candela Julio 
Published: August 2012

Abstract
Variability of the mesoscale eddy field in the Caribbean Sea is analyzed over the period 1993–2009 using geostrophic anomalies derived from altimeter data and a high-resolution regional model. The Colombia Basin presents the largest values of eddy kinetic energy (EKE) and its semiannual cycle, with a main peak in August–October and a secondary peak in February–March, is the dominant feature in the whole Caribbean EKE cycle. The analysis of energy conversion terms between low-frequency currents and eddies explains these peaks by enhanced baroclinic and barotropic instabilities, in response to seasonally varying currents in the region of the Guajira Peninsula. The semiannual acceleration of the atmospheric Caribbean low-level jet intensifies the southern Caribbean Current (sCC) twice a year in this region, together with its vertical and horizontal velocity shears. The asymmetry of the EKE seasonal cycle in the Colombia Basin is explained by a summer peak in the annual cycle of the whole sCC. Numerical results suggest that the arrival of more energetic North Brazil Current rings during part of the year have almost no impact on the seasonal cycle of EKE in the Colombia Basin. Instead, they are shown to contribute, together with the annual cycle of the Caribbean inflow through the southern passages of the Lesser Antilles, to an annual peak of EKE in the Venezuela Basin between May and August. At the interannual scale the mechanism is similar: interannual variability of the alongshore wind stress controls the speed of the southern Caribbean Current and the energy of the eddies in the Colombia Basin through instability.
An Analysis of Cold Season Supercell Storms Using the Synthetic Dual-Doppler Technique
Authors: Murphy Todd A. , Knupp Kevin R. 
Published: August 2012

Abstract
Cold season tornadic outbreaks occur with regularity in the southeastern United States; however, detailed analyses of parent supercell storms in the cold season environment (often low CAPE, high shear) are scarce. This is often because storms do not always move close enough to radars for a comprehensive single-Doppler analysis and significant topography or trees in the Southeast make it difficult for mobile radars to operate, thus limiting dual-Doppler coverage. However, during the Super Tuesday tornado outbreak of 5–6 February 2008, two tornadic supercell storms passed within 30–40 km of the Weather Surveillance Radar-1988 Doppler (WSR-88D) sites in Memphis and Nashville, Tennessee (KNQA and KOHX, respectively). The relative steadiness of these storms during passage, along with the large motion vector (from the southwest at 20–25 m s−1), allowed the application of a synthetic dual-Doppler (SDD) analysis. As such, a detailed analysis of these storms was completed, including examinations of low-level circulations, updraft strength and location, as well as retrievals and evaluations of perturbation pressure and the vertical pressure gradient. This study presents one of the first comprehensive analyses of cold season supercells using only one Doppler radar. Additionally, the relative success and failures of using the SDD technique on supercell storms are discussed. Major findings for the primary case include the updraft maximizing at a very low height (3.0 km AGL), and weak pressure forcing within the rear flank resulting in a nonexistent rear-flank downdraft (RFD).
A novel synthesis, characterization and application of an anionic Cr-complexed azo dye based on environmental considerations
Authors: Zarkogianni Maria , Coutouli-Argyropoulou Evdoxia , Samara Constantini , Anthemidis Aristidis , Nikolaidis Nikolaos , Tsatsaroni Eforia 
Published: August 2012

A simplified novel one pot method of synthesis of a Cr-complex anionic azo dye and the subsequent minimization of the Cr-content in the final dye by ultrafiltration was carried out. Ultrafiltration allows the production of highly concentrated purified metal-complex dyes with drastically reduced free metal and electrolyte content. All dyes were characterized by FT-IR, UV-Vis, NMR and their melting points. X-ray fluorescence analysis and atomic absorption measurements were performed for the determination of free and total Cr-content for the synthesized metal-complex dye before and after ultrafiltration. All of the synthesized dyes (before and after ultrafiltration) were applied for the dyeing of wool and polyamide fibres, and colour measurements and fastness property tests were carried out. The wash and light fastness properties of the dyeings were excellent for the metal-complex dyes, but inferior for the non-metallized dye.
Blood pressure and plasma renin activity responses to different strategies to inhibit the renin-angiotensin-aldosterone system during exercise
Authors: Williams Bryan , Baschiera Fabio , Lacy Peter S , Botha Jaco , Prescott Margaret F , Brunel Patrick 
Published: August 2012

Objective: The effect of two different strategies for renin–angiotensin–aldosterone system (RAAS) blockade; direct renin inhibition (DRI) versus angiotensin receptor blockade (ARB) on blood pressure (BP) and plasma renin activity (PRA) was compared during exercise. Methods: Hypertensive adults were randomised to aliskiren (300 mg once daily, n=33) or valsartan (320 mg once daily, n=35). BP and PRA were measured during treadmill exercise (Bruce protocol), at baseline, end of treatment (eight weeks), and after treatment withdrawal (48 hours after last dose). Results: After eight weeks treatment, Aliskiren inhibited PRA (>80%) at rest and during exercise, with inhibition remaining undiminished 48 hours after treatment withdrawal. In contrast, valsartan increased PRA at rest, and more-so during exercise (>400%). Angiotensin receptor blockade, as indicated by PRA increase, was reduced, 48 hours after valsartan treatment withdrawal, suggesting more sustained RAAS blockade with aliskiren. Despite divergent effects on PRA, similar exercise-induced changes in BP were seen. The primary outcome, the rise in systolic BP from rest to peak exercise (baseline to after treatment withdrawal) did not differ between treatments ( p=0.25). Conclusion: Measurement of PRA is a more sensitive index of RAAS blockade than the BP response during exercise. Furthermore, after treatment withdrawal, aliskiren provides more sustained RAAS inhibition than valsartan at rest and during exercise.
Effect of MHC and non-MHC donor/recipient genetic disparity on the outcome of allogeneic HCT
Authors: Warren Edus H. , Zhang Xinyi Cindy , Li Shuying , Fan Wenhong , Storer Barry E. , Chien Jason W. , Boeckh Michael J. , Zhao Lue Ping , Martin Paul J. , Hansen John A. 
Published: August 2012

AbstractThe outcome of allogeneic hematopoietic cell transplantation is influenced by donor/recipient genetic disparity at loci both inside and outside the MHC on chromosome 6p. Although disparity at loci within the MHC is the most important risk factor for the development of severe GVHD, disparity at loci outside the MHC that encode minor histocompatibility (H) antigens can elicit GVHD and GVL activity in donor/recipient pairs who are otherwise genetically identical across the MHC. Minor H antigens are created by sequence and structural variations within the genome. The enormous variation that characterizes the human genome suggests that the total number of minor H loci is probably large and ensures that all donor/recipient pairs, despite selection for identity at the MHC, will be mismatched for many minor H antigens. In addition to mismatch at minor H loci, unrelated donor/recipient pairs exhibit genetic disparity at numerous loci within the MHC, particularly HLA-DP, despite selection for identity at HLA-A, -B, -C, and -DRB1. Disparity at HLA-DP exists in 80% of unrelated pairs and clearly influences the outcome of unrelated hematopoietic cell transplantation; the magnitude of this effect probably exceeds that associated with disparity at any locus outside the MHC.
Safety and pharmacokinetics of a novel recombinant fusion protein linking coagulation factor IX with albumin (rIX-FP) in hemophilia B patients
Authors: Santagostino Elena , Negrier Claude , Klamroth Robert , Tiede Andreas , Pabinger-Fasching Ingrid , Voigt Christine , Jacobs Iris , Morfini Massimo 
Published: August 2012

Abstract
A recombinant fusion protein linking coagulation factor IX (FIX) with human albumin (rIX-FP) has been developed to facilitate hemophilia B treatment by less frequent FIX dosing. This first-in-human dose-escalation trial in 25 previously treated subjects with hemophilia B (FIX ≤ 2 IU/dL) examined the safety and pharmacokinetics of 25, 50, and 75 IU/kg rIX-FP. Patients in the 50-IU/kg cohort underwent a comparative pharmacokinetics assessment with their previous FIX product (plasma-derived or recombinant). No allergic reactions or inhibitors were observed. Four mild, possibly treatment-related adverse events were reported. In the 50-IU/kg cohort (13 subjects), the mean half-life of rIX-FP was 92 hours, more than 5 times longer than the subjects' previous FIX product. After 25 or 50 IU/kg rIX-FP administration, the baseline-corrected mean FIX activity remained elevated at day 7 (7.4 IU/dL and 13.4 IU/dL, respectively) and day 14 (2.5 IU/dL and 5.5 IU/dL, respectively). The incremental recovery of rIX-FP was higher than both recombinant and plasma-derived FIX (1.4 vs 0.95 and 1.1 IU/dL per IU/kg, respectively). These results demonstrated both the safety and improved pharmacokinetics of rIX-FP, thus indicating this new product with extended half-life as possibly able to control and prevent bleeding with less frequent injection. The trial was registered at www.clinicaltrials.gov as no. NCT01233440.
Defective regulatory B-cell compartment in patients with immune thrombocytopenia
Authors: Li Xiaojuan , Zhong Hui , Bao Weili , Boulad Nayla , Evangelista Jessie , Haider Muhammad Anis , Bussel James , Yazdanbakhsh Karina 
Published: August 2012

AbstractB lymphocytes producing antiplatelet autoantibodies play a major role in autoimmune thrombocytopenia (ITP). However, certain B cells, including the human CD19+CD24hiCD38hi subpopulation, possess regulatory functions mediated partly by IL-10. In a cohort of chronic ITP patients with low platelet counts who consisted of patients off treatment, we found a lower frequency of CD19+CD24hiCD38hi in the peripheral compartment of nonsplenectomized patients (P = .03). IL-10 expression after activation was decreased in all ITP circulating CD19+ subpopulations (P < .03), and inhibition of monocyte TNF-α expression by activated B cells was reduced in patients with platelet numbers of < 50 × 109 cells/L (P = .001), indicating that regulatory B cells of patients with ITP are functionally impaired in their ability to dampen monocyte activation. Interestingly, in nonsplenectomized patients whose platelet counts were elevated after treatment with thrombopoietic agents, the frequency of CD19+CD24hiCD38hi B cells was increased compared with those before treatment (P = .02). Altogether, these data indicate a compromised regulatory B-cell com-partment as an additional defect in immune regulation in patients with chronic ITP that may be restored in responders to thrombopoietic treatment.
STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia
Authors: Jerez Andres , Clemente Michael J. , Makishima Hideki , Koskela Hanna , LeBlanc Francis , Peng Ng Kwok , Olson Thomas , Przychodzen Bartlomiej , Afable Manuel , Gomez-Segui Ines , Guinta Kathryn , Durkin Lisa , Hsi Eric D. , McGraw Kathy , Zhang Dan , Wlodarski Marcin W. , Porkka Kimmo , Sekeres Mikkael A. , List Alan , Mustjoki Satu , Loughran Thomas P. , Maciejewski Jaroslaw P. 
Published: August 2012

AbstractChronic lymphoproliferative disorders of natural killer cells (CLPD-NKs) and T-cell large granular lymphocytic leukemias (T-LGLs) are clonal lymphoproliferations arising from either natural killer cells or cytotoxic T lymphocytes (CTLs). We have investigated for distribution and functional significance of mutations in 50 CLPD-NKs and 120 T-LGL patients by direct sequencing, allele-specific PCR, and microarray analysis. STAT3 gene mutations are present in both T and NK diseases: approximately one-third of patients with each type of disorder convey these mutations. Mutations were found in exons 21 and 20, encoding the Src homology 2 domain. Patients with mutations are characterized by symptomatic disease (75%), history of multiple treatments, and a specific pattern of STAT3 activation and gene deregulation, including increased expression of genes activated by STAT3. Many of these features are also found in patients with wild-type STAT3, indicating that other mechanisms of STAT3 activation can be operative in these chronic lymphoproliferative disorders. Treatment with STAT3 inhibitors, both in wild-type and mutant cases, resulted in accelerated apoptosis. STAT3 mutations are frequent in large granular lymphocytes suggesting a similar molecular dysregulation in malignant chronic expansions of NK and CTL origin. STAT3 mutations may distinguish truly malignant lymphoproliferations involving T and NK cells from reactive expansions.
Effectiveness of genomic prediction on milk flow traits in dairy cattle
Authors: Gray Kent A , Cassady Joseph P , Huang Yijian , Maltecca Christian 
Published: July 2012

Abstract

Background
Milkability, primarily evaluated by measurements of milking speed and time, has an economic impact in milk production of dairy cattle. Recently the Italian Brown Swiss Breeders Association has included milking speed in genetic evaluations. The main objective of this study was to investigate the possibility of implementing genomic selection for milk flow traits in the Italian Brown Swiss population and thereby evaluate the potential of genomic selection for novel traits in medium-sized populations. Predicted breeding values and reliabilities based on genomic information were compared with those obtained from traditional breeding values.

Methods
Milk flow measures for total milking time, ascending time, time of plateau, descending time, average milk flow and maximum milk flow were collected on 37 213 Italian Brown Swiss cows. Breeding values for genotyped sires (n = 1351) were obtained from standard BLUP and genome-enhanced breeding value techniques utilizing two-stage and single-step methods. Reliabilities from a validation dataset were estimated and used to compare accuracies obtained from parental averages with genome-enhanced predictions.

Results
Genome-enhanced breeding values evaluated using two-stage methods had similar reliabilities with values ranging from 0.34 to 0.49 for the different traits. Across two-stage methods, the average increase in reliability from parental average was approximately 0.17 for all traits, with the exception of descending time, for which reliability increased to 0.11. Combining genomic and pedigree information in a single-step produced the largest increases in reliability over parent averages: 0.20, 0.24, 0.21, 0.14, 0.20 and 0.21 for total milking time, ascending time, time of plateau, descending time, average milk flow and maximum milk flow, respectively.

Conclusions
Using genomic models increased the accuracy of prediction compared to traditional BLUP methods. Our results show that, among the methods used to predict genome-enhanced breeding values, the single-step method was the most successful at increasing the reliability for most traits. The single-step method takes advantage of all the data available, including phenotypes from non-genotyped animals, and can easily be incorporated into current breeding evaluations.
Evidence for a divergence in function between two glucocorticoid receptors from a basal teleost
Authors: Li Yi , Sturm Armin , Cunningham Phil , Bury Nicolas R 
Published: August 2012

Abstract

Background
Duplicated glucocorticoid receptors (GR) are present in most teleost fish. The evolutionary advantage of retaining two GRs is unclear, as no subtype specific functional traits or physiological roles have been defined. To identify factors driving the retention of duplicate GRs in teleosts, the current study examined GRs in representatives of two basal ray-finned fish taxa that emerged either side of the teleost lineage whole genome duplication event (WGD) event, the acipenseriform, Acipenser ruthenus, (pre-WGD) and the osteoglossimorph, Pantodon buchholzi, (post-WGD).

Results
The study identified a single GR in A. ruthenus (ArGR) and two GRs in P. buchholzi (PbGR1 and PbGR2). Phylogenetic analyses showed that ArGR formed a distinct branch separate from the teleosts GRs. The teleost GR lineage was subdivded into two sublineages, each of which contained one of the two P. buchholzi GRs. ArGR, PbGR1 and PbGR2 all possess the unique 9 amino acid insert between the zinc-fingers of the DNA-binding domain that is present in one of the teleost GR lineages (GR1), but not the other (GR2). A splice variant of PbGR2 produces an isoform that lacked these 9 amino acids (PbGR2b). Cortisol stimulated transactivation activity of ArGR, PbGR2b and PbGR1 in vitro; with PbGR2b and PbGR1, the glucocorticoid 11-deoxycortisol was a more potent agonist than cortisol. The hormone sensitivity of PbGR2b and PbGR1 differed in the transactivation assay, with PbGR2b having lower EC50 values and greater fold induction.

Conclusions
The difference in transactivation activity sensitivity between duplicated GRs of P. buchholzi suggests potential functional differences between the paralogs emerged early in the teleost lineage. Given the pleiotropic nature of GR function in vertebrates, this finding is in accordance with the hypothesis that duplicated GRs were potentially retained through subfunctionalisation followed by gene sharing. A 9 amino acid insert in the DNA-binding domain emerged in basal ray-finned fish GRs. However, the presence of a PbGR2 splice variant that lacks this insert, as well as the loss of the exon encoding these amino acids in the genes encoding for other teleost GR2 suggests the selection of two receptors with different DNA-binding domain structures in teleosts.