bluuebunny/crossref_metadata_2025_split huggingface dataset:
Touch Imprint Cytology Evaluation of Sentinel Lymph Node in Breast Cancer
Authors: Khanna Rahul , Bhadani Shilpi , Khanna Seema , Pandey Manoj , Kumar Mohan 
Published: April 2011

AbstractBackgroundMost centers use lymphoscintiscan for identification of a sentinel lymph node (SLN) and frozen section for its evaluation. The aim of the present study was to assess the accuracy of peritumoral methylene blue dye injection for SLN identification and the technique of touch imprint cytology (TIC) for its evaluation.Patients and MethodsOne hundred and eight fine needle aspiration cytology (FNAC)–proven breast cancer patients with clinically N0 axilla were recruited for the study. Prior to the induction of anesthesia, 5 ml of 1% methylene blue was injected in the peritumoral region to stain the sentinel node, following which conventional modified radical mastectomy was performed. Touch imprint cytology was obtained from the cut surface of the SLN, and then the SLN along with all nonsentinel nodes were sent for histopathology.ResultsIntraoperative identification of a blue node was possible in 102 of 108 patients (94%). Touch imprint cytology had a sensitivity of 88%, specificity of 98%, and overall diagnostic accuracy of 94% for diagnosing metastasis in the SLN. The false positive rate for malignancy of TIC versus histology was 2.5% and the false negative rate 7.8%.ConclusionsBlue dye lymphatic mapping by peritumoral injection of methylene blue was found to be accurate and cost effective for SLN identification. It avoids the expenses of lymphoscintiscanning, which requires special infrastructure and expertise with a significant learning curve. The identified SLN can, with reasonable accuracy, be assessed for metastasis by TIC. The frequently used method of frozen section requires a cryostat and a pathologist trained in the technique. Additionally scanty SLN tissue can be wasted in the cryostat and freezing artifacts can be introduced in the imprint, both of which are avoided by TIC.
Surgical Care in the Solomon Islands: A Road Map for Universal Surgical Care Delivery
Authors: Natuzzi Eileen S. , Kushner Adam , Jagilly Rooney , Pickacha Douglas , Agiomea Kaeni , Hou Levi , Houasia Patrick , Hendricks Phillip L. , Ba’erodo Dudley 
Published: April 2011

AbstractBackgroundAccess to surgical care and emergency obstetrical care is limited in low‐income countries. The Solomon Islands is one of the poorest countries in the Pacific region. Access to surgical care in Solomon Islands is limited and severely affected by a country made up of islands. Surgical care is centralized to the National Referral Hospital (NRH) on Guadalcanal, leaving a void of care in the provinces where more than 80% of the people live.MethodsTo assess the ability to provide surgical care to the people living on outer islands in the Solomon Islands, the provincial hospitals were evaluated using the World Health Organization’s Global Initiative for Emergency and Essential Surgical Care Needs Assessment Tool questionnaire. Data on infrastructure, workforce, and equipment available for treating surgical disease was collected at each provincial hospital visited.ResultsSurgical services are centralized to the NRH on Guadalcanal in Solomon Islands. Two provincial hospitals provide surgical care when a surgeon is available. Six of the hospitals evaluated provide only very basic surgical procedures. Infrastructure problems exist at every hospital including lack of running water, electricity, adequate diagnostic equipment, and surgical supplies. The number of surgeons and obstetricians employed by the Ministry of Health is currently inadequate for delivering care at the outer island hospitals.ConclusionsShortages in the surgical workforce can be resolved in Solomon Islands with focused training of new graduates. Training surgeons locally, in the Pacific region, can minimize the “brain drain.” Redistribution of surgeons and obstetricians to the provincial hospitals can be accomplished by creating supportive connections between these hospitals, the NRH, and international medical institutions.
Robotic hepatobiliary and pancreatic surgery: a cohort study
Authors: Chan Oliver C. Y. , Tang Chung Ngai , Lai Eric C. H. , Yang George P. C. , Li Michael K. W. 
Published: April 2011

AbstractBackgroundRobotic surgery has emerged as one of the most promising surgical advances since its launch at the turn of the millennium. Despite its worldwide acceptance in many different surgical specialties, the use of robotic assistance in the field of hepatobiliary and pancreatic (HBP) surgery remains relatively unexplored. This article aims to evaluate the efficacy and outcomes of robotic HBP surgery in a single surgical center.MethodsBetween May 2009 and December 2010, all patients admitted to our unit for robotic HBP surgery were evaluated. A retrospective analysis of a prospectively maintained database on clinical outcomes was performed.ResultsThere were 55 robotic HBP operations performed during the study period. There were 27 robotic liver resections (left lateral sectionectomiesn = 17, left hepatectomyn = 1, other segmentectomiesn = 2 and wedge resectionsn = 7), 12 robotic pancreatic procedures (Whipple's operationsn = 8, spleen‐preserving distal pancreatectomiesn = 2, double bypassn = 1 and cystojejunostomyn = 1) and 16 biliary procedures (biliary enteric bypassn = 9, bile duct exploration and related proceduresn = 7). The median postoperative hospital stays for robotic liver resections, biliary procedures and pancreatic operations were 5.5 days (range 3–11 days), 6 days (range 4–11 days) and 12 days (range 6–21 days), respectively. Morbidities for liver resection, biliary procedures and pancreatic operations were 7.4, 18 and 33%, respectively. There was no mortality in our series.ConclusionsRobotic surgery is feasible and can be safely performed in patients with complicated HBP pathologies. Further evaluation with clinical trials is required to validate its real benefits.
Interactions and Solubilization of Disperse Dye with Modified Gemini Surfactants: Investigation Using the Taguchi Method
Authors: Su Te‐Li , Lai Chiu‐Chun , Tsai Pi‐Chen 
Published: April 2011

AbstractSince the interaction of a disperse dye with a surfactant in micelles plays an important role in textile industry, the purpose of this study was to find out the optimal conditions that describe the dye–surfactant interaction. The effects of temperature, gemini surfactant concentration and ethylene‐oxide chain length of gemini surfactants were investigated and optimized using the Taguchi method. First, this method was adopted to carry out the parameter design, and the interaction parameters that would affect the absorbance of UV–visible spectrum were chosen as the control factors. After the selection of an appropriate orthogonal array, an analysis of variance was applied to decide upon the optimal conditions of solubilization parameters and determine the significant factors of the UV–visible absorbance. The optimized conditions were as follow: surfactant concentration 5.6 × 10−4 M, length of ethylene oxide chain 20, and temperature 40 °C. Finally, the experimental results of confirmation tests with a confidence interval of 95%, indicated that the experiment is reliable and reproducible. Under these optimum conditions, it was also determined that the solubilization of disperse dye using modified gemini surfactants increased when the surfactant concentration and the ethylene oxide chain length increased.
Pharmacokinetics of alkylresorcinol metabolites in human urine
Authors: Söderholm Päivi P. , Lundin Johan E. , Koskela Anja H. , Tikkanen Matti J. , Adlercreutz Herman C. 
Published: April 2011

Wholegrain cereals are reported to promote beneficial health effects. Wholegrain wheat and rye are almost exclusive sources of alkylresorcinols, and intact alkylresorcinols together with their plasma and urinary metabolites, 3-(3,5-dihydroxyphenyl)-1-propanoic acid (DHPPA) and 3,5-dihydroxybenzoic acid (DHBA), have been proposed as biomarkers of the intake of these foods in humans. The pharmacokinetics of alkylresorcinols and their metabolites in plasma have been determined but not that of the urinary metabolites. We aimed to characterise the urinary pharmacokinetics of alkylresorcinol metabolites in humans to evaluate their potential as biomarkers of wholegrain wheat and rye. A group of fifteen volunteers followed a low-alkylresorcinol diet for 2 d before ingesting a single dose of rye bread, containing 100 mg alkylresorcinols. Urine was collected between baseline (0 h) and 25 h after administration. Thereafter alkylresorcinol metabolites were quantified by HPLC with coulometric electrode array detection. Maximum excretion rates were observed at 5–6 h for both metabolites, DHPPA being predominant over DHBA and also possessing a greater area under the curve0–25 h. Total urinary recovery between 0 and 25 h yielded 43 % of ingested alkylresorcinols, and at 25 h significant amounts of metabolites were still retained in the body, suggesting that even a spot urine sample may be sufficient to indicate whether or not wholegrain wheat or rye is a daily dietary component. These results support the use of urinary DHPPA and DHBA as biomarkers of wholegrain wheat and rye and enable new potential for studying the association between wholegrain intake and diseases, even in the absence of dietary data.
The nutrition transition in the Republic of Ireland: trends in energy and nutrient supply from 1961 to 2007 using Food and Agriculture Organization food balance sheets
Authors: Sheehy Tony , Sharma Sangita 
Published: April 2011

Over the course of the last 50 years the Republic of Ireland has gone from being one of the poorest countries in Europe to one of the richest; however, it is now experiencing increasing rates of obesity and non-communicable chronic disease. Although several national nutrition surveys have been carried out in Ireland since 1990, there is little information on the Irish diet before then. We analysed the FAO food balance sheets for Ireland from 1961 to 2007 in order to characterise the changes in energy and nutrient supply that took place during that period. Food balance sheets were downloaded from the FAOSTAT database and per capita supply of commodities was analysed using dietary analysis software. Energy from carbohydrate as a percentage of total energy fell from 55 % in 1961 to 46 % in 2007, whereas energy from fat increased from 29 % to 34 %; these values are well outside WHO recommendations for the prevention of chronic disease. Energy from alcohol as a percentage of total energy has doubled within the last 20 years. On a nutrient-density basis, vitamins and minerals met or exceeded WHO recommendations, apart from vitamin D, folate, Ca and Fe. Although there are methodological limitations associated with the use of food balance sheets, the present results demonstrate that the current imbalances in the Irish diet were already evident several decades ago. Because they are so long established, they will be difficult to reverse unless major public health nutrition interventions are implemented.
Geometry, kinematics and fracture pattern of the Bangestan anticline, Zagros, SW Iran
Authors: TAVANI STEFANO , STORTI FABRIZIO , SOLEIMANY BAHMAN , FALLAH MOHAMMAD , MUÑOZ JOSEP A. , GAMBINI ROBERTO 
Published: April 2011

AbstractThrust-related anticlines in the Zagros Simply Folded Belt provide excellent exposed analogue structures for fractured reservoirs located in the more external sectors of the belt. In these structures it is possible to study the fracture network attributes and understand their relationships to the folding process, thus gathering fundamental information for fracture modelling in reservoirs. In this work we analyse the mesoscopic deformation pattern of the NW–SE-trending Bangestan anticline (SW Zagros, Iran) and discuss its relationship to the kinematic evolution of the hosting structure. The deformation pattern mostly includes extensional structures and pressure solution cleavages striking parallel to the fold axial trend (i.e. longitudinal), transversal extensional structures, and N–S- and E–W-striking extensional structures (oriented oblique to the fold axis). With the aid of deep wells and a transversal reflection seismic profile, we constructed a balanced cross-section of the anticline and propose a kinematic evolution pathway constrained by the mesoscopic deformation pattern. Longitudinal and transversal deformation structures developed before and/or in the very early stages of fold growth. During this stage, the Bangestan anticline grew as a set of unconnected décollement anticlines involving the Cambrian to Pliocenic sedimentary cover. In a later stage, inherited basement faults were reactivated with a right-lateral strike-slip component and the previously developed anticlines propagated laterally up to their complete linkage and thrust breakthrough. This produced the right-lateral strike-slip reactivation of longitudinal joints and the development of N–S- and E–W-striking extensional structures, which were also frequently reworked as strike-slip faults.
Portfolio allocation for public pension funds
Authors: PENNACCHI GEORGE , RASTAD MAHDI 
Published: April 2011

AbstractThis paper presents a model of a public pension fund's choice of portfolio risk. Optimal portfolio allocations are derived when pension fund management maximize the utility of wealth of a representative taxpayer or when pension fund management maximize their own utility of compensation. The model's implications are examined using annual data on the portfolio allocations and plan characteristics of 125 state pension funds over the 2000–2009 period. Consistent with agency behavior by public pension fund management, we find evidence that funds chose greater overall asset – liability portfolio risk following periods of relatively poor investment performance. In addition, pension plans that select a relatively high rate with which to discount their liabilities tend to choose riskier portfolios. Moreover, consistent with a desire to gamble for higher benefits, pension plans take more risk when they have greater representation by plan participants on their Boards of Trustees.
Stability of hydrocarbons at deep Earth pressures and temperatures
Authors: Spanu Leonardo , Donadio Davide , Hohl Detlef , Schwegler Eric , Galli Giulia 
Published: April 2011

Determining the thermochemical properties of hydrocarbons (HCs) at high pressure and temperature is a key step toward understanding carbon reservoirs and fluxes in the deep Earth. The stability of carbon-hydrogen systems at depths greater than a few thousand meters is poorly understood and the extent of abiogenic HCs in the Earth mantle remains controversial. We report ab initio molecular dynamics simulations and free energy calculations aimed at investigating the formation of higher HCs from dissociation of pure methane, and in the presence of carbon surfaces and transition metals, for pressures of 2 to 30 GPa and temperatures of 800 to 4,000 K. We show that for T≥2,000 K and P≥4 GPa HCs higher than methane are energetically favored. Our results indicate that higher HCs become more stable between 1,000 and 2,000 K and P≥4 GPa. The interaction of methane with a transition metal facilitates the formation of these HCs in a range of temperature where otherwise pure methane would be metastable. Our results provide a unified interpretation of several recent experiments and a detailed microscopic model of methane dissociation and polymerization at high pressure and temperature.
A simple cost-effective and scale-less empirical approach to harvest strategies
Authors: Prince Jeremy D. , Dowling Natalie A. , Davies Campbell R. , Campbell Robert A. , Kolody Dale S. 
Published: April 2011

Abstract
Prince, J. D., Dowling, N. A., Davies, C. R., Campbell, R. A., and Kolody, D. S. 2011. A simple cost-effective and scale-less empirical approach to harvest strategies. – ICES Journal of Marine Science, 68: 947–960. An empirical harvest strategy for an Australian longline fishery was developed and tested using harvest strategy evaluation. The approach is based on catch rate and size composition indices and iteratively drives the population towards a target level of spawning potential ratio. The simulation model assumed traditional age-structured population dynamics. The results demonstrate that the empirical approach represents a promising feedback strategy that becomes more precautionary as data errors and recruitment variance increase. Given the urgent need for formal harvest strategies to replace ad hoc decision-making in data-poor fisheries, the approach offers considerable promise. Independent implementation at local scales across the range of a species is speculated to result in management that is robust to uncertainty about stock structure.
Predicting habitat to optimize sampling of Pacific sardine (Sardinops sagax)
Authors: Zwolinski Juan P. , Emmett Robert L. , Demer David A. 
Published: April 2011

AbstractZwolinski, J. P., Emmett, R. L., and Demer, D. A. 2011. Predicting habitat to optimize sampling of Pacific sardine (Sardinops sagax). – ICES Journal of Marine Science, 68: 867–879. More than 40 years after the collapse of the fishery for Pacific sardine, a renewed fishery has emerged off the west coasts of the United States and Canada. The daily egg production method (DEPM) and acoustic-trawl surveys are performed annually and, to minimize the uncertainties in the estimates, sampling effort needs to be allocated optimally. Here, based on a 12-year dataset including the presence/absence of sardine eggs and concomitant remotely sensed oceanographic variables, a probabilistic generalized additive model is developed to predict spatio-temporal distributions of habitat for the northern stock of Pacific sardine in the California Current. Significant relationships are identified between eggs and sea surface temperature, chlorophyll a concentration, and the gradient of sea surface altitude. The model accurately predicts the habitat and seasonal migration pattern of sardine, irrespective of spawning condition. The predictions of potential habitat are validated extensively by fishery landings and net-sample data from the northeast Pacific. The predicted habitat can be used to optimize the time and location of the DEPM, acoustic-trawl, and aerial surveys of sardine. The method developed and illustrated may be applicable too to studies of other stocks of sardine and other epipelagic fish in other eastern boundary, upwelling regions.
Using bycatch data to understand habitat use of small cetaceans: lessons from an experimental driftnet fishery
Authors: Stenson Garry B. , Benjamins Steven , Reddin David G. 
Published: April 2011

AbstractStenson, G. B., Benjamins, S., and Reddin, D. G. 2011. Using bycatch data to understand habitat use of small cetaceans: lessons from an experimental driftnet fishery. – ICES Journal of Marine Science, 68: 937–946. Many marine mammals inhabit offshore areas where it is difficult to determine distribution and abundance. Historical bycatch data of marine mammals in the Northwest Atlantic obtained from the Canadian experimental Atlantic salmon (Salmo salar) driftnet fishery were examined to obtain information on seasonal distribution and relative abundance. From 1965 to 2001, 47 cruises were undertaken totalling 12 566.5 km-h of fishing effort; four species of small cetacean and two species of pinniped were caught. Harbour porpoises (Phocoena phocoena) were the most frequently caught species in all areas except the Labrador Sea, where Atlantic white-sided dolphins (Lagenorhynchus acutus) were more common. Long-finned pilot whales (Globicephala melas), common dolphins (Delphinus delphis), harp seals (Pagophilus groenlandicus), and harbour seals (Phoca vitulina) were also taken occasionally. Although typically considered an inshore species, harbour porpoises were regularly reported in deep water (>2000 m), in the Newfoundland Basin and Labrador Sea. Atlantic white-sided dolphins were often caught along the edge of the continental shelf and appeared to prefer relatively warm water. Finally, catch records indicate that waters of the Newfoundland Basin and Southern Grand Banks may contain important winter habitat for several small species of cetacean.
Genetic identification of farmed and wild Atlantic cod, Gadus morhua, in coastal Norway
Authors: Glover Kevin A. , Dahle Geir , Jørstad Knut E. 
Published: April 2011

AbstractGlover, K. A., Dahle, G., and Jørstad, K. E. 2011. Genetic identification of farmed and wild Atlantic cod, Gadus morhua, in coastal Norway. – ICES Journal of Marine Science, 68: 901–910. Each year thousands of Atlantic cod escape from Norwegian fish farms. To investigate the potential for the genetic identification of farmed–escaped cod in the wild, three case studies were examined. Samples of farmed, recaptured farmed escapees, and wild cod were screened for ten microsatellite loci and the Pan I locus. Variable genetic differences were observed among cod sampled from different farms and cages (pairwise FST = 0.0–0.1), and in two of the case studies, the most likely farm(s) of origin for most of the recaptured escapees were identified. In case study 2, wild cod were genetically distinct from both farmed fish (pairwise FST = 0.026–0.06) and recaptured farmed–escaped cod (pairwise FST = 0.029 and 0.039), demonstrating the potential to detect genetic interactions in that fjord. Genetic identification of escapees was more challenging in case study 3, and some morphologically characterized wild cod were found to most likely represent farmed escapees. It is concluded that where cod are farmed in the same region as their own parents/grandparents were initially sourced, or where farmed escapees originate from multiple sources, quantifying genetic interactions with wild populations will be challenging with neutral or nearly neutral markers such as microsatellites.
Tissue-Specific Regulation of Gibberellin Biosynthesis in Developing Pea Seeds
Authors: Nadeau Courtney D. , Ozga Jocelyn A. , Kurepin Leonid V. , Jin Alena , Pharis Richard P. , Reinecke Dennis M. 
Published: April 2011

Abstract
Previous work suggests that gibberellins (GAs) play an important role in early seed development. To more fully understand the roles of GAs throughout seed development, tissue-specific transcription profiles of GA metabolism genes and quantitative profiles of key GAs were determined in pea (Pisum sativum) seeds during the seed-filling development period (8–20 d after anthesis [DAA]). These profiles were correlated with seed photoassimilate acquisition and storage as well as morphological development. Seed coat growth (8–12 DAA) and the subsequent dramatic expansion of branched parenchyma cells were correlated with both transcript abundance of GA biosynthesis genes and the concentration of the growth effector GA, GA1. These results suggest GA1 involvement in determining the rate of seed coat growth and sink strength. The endosperm’s PsGA20ox transcript abundance and the concentration of GA20 increased markedly as the endosperm reached its maximum volume (12 DAA), thus providing ample GA20 substrate for the GA 3-oxidases present in both the embryo and seed coat. Furthermore, PsGA3ox transcript profiles and trends in GA1 levels in embryos at 10 to 16 DAA and also in embryo axes at 18 DAA suggest localized GA1-induced growth in these tissues. A shift from synthesis of GA1 to that of GA8 occurred after 18 DAA in the embryo axis, suggesting that deactivation of GA1 to GA8 is a likely mechanism to limit embryo axis growth and allow embryo maturation to proceed. We hypothesize that GA biosynthesis and catabolism are tightly regulated to bring about the unique developmental events that occur during seed growth, development, and maturation.