bluuebunny/crossref_metadata_2025_split huggingface dataset:
HPV genotype prevalence in women with abnormal pap smears in Melbourne, Australia
Authors: Stevens Matthew P. , Garland Suzanne M. , Tan Jeffrey H. , Quinn Michael A. , Petersen Rodney W. , Tabrizi Sepehr N. 
Published: May 2009

AbstractCarcinoma of the cervix and its precursor, high‐grade cervical intraepithelial neoplasia (CIN2/3), are associated with persistent oncogenic Human papillomavirus (HPV) infection, particularly HPV 16 and 18. HPV genotype distribution varies with severity of cervical disease, patient demographics such as age, as well as geographical location. In this study, HPV genotype prevalence was determined, using the Roche Linear Array genotyping test, among a cohort of 1,676 women being managed with ablative or excisional treatment following colposcopically directed biopsies, who were referred initially due to cytological abnormalities. HPV genotype prevalence, including presence of single and multiple infections was assessed against both histological diagnosis and age. Overall, 83.9% of women were identified as HPV positive, comprising of 32.2% single and 51.7% multiple HPV infections. Of those with an available histological diagnosis at time‐of‐treatment (n = 899), HPV positivity increased significantly with disease severity: 62.4% (normal), 77.6% (CIN1), 92.6% (CIN2), and 97.9% (≥CIN3) (P < 0.006). Similarly, a significant increase in high‐risk (HR) HPV detection was observed with severity of disease (P < 0.005). The five most prevalent genotypes were HPV 16 (35.1%), 31 (12.6%), 51 (11.1%), 52 (9.9%), and 18 (8.5%). HPV 16 was the only genotype to demonstrate a significant increase in prevalence with increasing severity of histological or cytological disease (P < 0.0001). Multiple HPV infections, including multiple HR‐HPV infections, declined significantly with age (P < 0.02). These findings provide the largest dataset of HPV genotype prevalence rates within Australian women, though are not representative of the general population. J. Med. Virol. 81:1283–1291, 2009. © 2009 Wiley‐Liss, Inc.
Tracking the entry routes of hepatitis C virus as a surrogate of HIV in an HIV‐low prevalence country, the Philippines
Authors: Kageyama Seiji , Agdamag Dorothy May D. , Alesna Evelyn T. , Abellanosa‐Tac‐An Ilya P. , Corpuz Aura C. , Telan Elizabeth Freda O. , Que Ernesto R. , Leaño Prisca Susan A. , Jereza Lourdes D. , Emphasis Yvonne Ethyl E. , Prasetyo Afiono A. , Tanimoto Tomoaki , Ichimura Hiroshi 
Published: May 2009

AbstractFrom 2002 to 2007, 1,590 individuals were enrolled in an active surveillance program conducted in Metro Cebu, Philippines, where the anti‐HCV‐positive rate was significantly and constantly high among injecting drug users (83%, 793/960; 71–88%), especially among those living in downtown (89%, 683/770; 87–100%), despite the extremely low percentage of anti‐HIV‐positives (0.34%, 3/874). Sampling areas were then enlarged nationwide and the number of samples increased to 2,645 at the end of 2007. A total of 444 samples were positive for HCV RNA. Phylogenetic analysis based on NS5B and E1–E2 regions revealed that the most dominant HCV subtype was 1a, and followed by 2b, 2a, and 1b, and that the HCV strains had the largest variety in Metro Manila and its vicinity (P < 0.01). Interestingly, subtype 1b was detected solely in Metro Manila, and four HCV strains collected in this area showed higher homology to specific foreign strains retrieved from the Genbank/EMBL/DDBJ database with bootstrap values of 68–95% comparing with other strains analyzed in this nationwide study. These data suggest that HCV strains may be introduced occasionally into the Philippines possibly through Metro Manila as a main entry point. Considering the fact that an HIV epidemic started primarily via contaminated needle sharing in Asia, the constantly high rate of HCV infections and the newly introduced foreign HCV strains in the absence of HIV epidemic warrant further investigation on HCV entry and spread for early detection of an HIV epidemic in the Philippines. J. Med. Virol. 81:1157–1162, 2009. © 2009 Wiley‐Liss, Inc.
A peptide derived from hepatitis C virus (HCV) core protein inducing cellular responses in patients with HCV with various HLA class IA alleles
Authors: Niu Yamei , Komatsu Nobukazu , Komohara Yoshihiro , Matsueda Satoko , Yutani Shigeru , Ishihara Yuki , Itou Minoru , Yamada Akira , Itoh Kyogo , Shichijo Shigeki 
Published: May 2009

AbstractC35‐44 peptide is a well known HLA‐A2‐restricted CTL epitope originating from hepatitis C virus (HCV) core protein. It was reported that the majority of HCV positive patients had significant levels of serum IgG specific to this peptide. This study addressed whether C35‐44 peptide could induce CTL activity restricted to various HLA class IA alleles or could not. This peptide demonstrated binding activity to HLA‐A*2402, ‐A*2601, ‐A*3101, and ‐A*3303 molecules, but not to HLA‐A*1101 by means of stabilization assay. This peptide also induced CTL activity restricted to each of them, except HLA‐A11+ peripheral blood mononuclear cells from HCV 1b+ patients by means of 51Cr‐release assay. With regard to HLA‐A2 subtypes, this peptide demonstrated binding activity to HLA‐A*0201 and ‐A*0206, but not to ‐A*0207 molecules. Furthermore, this peptide induced CTL activity from both the patients and healthy donors with all the HLA class IA molecules mentioned above by means of interferon‐γ production assay. These results may provide new insights for the development of a novel peptide vaccine against HCV compatible with various HLA class IA types. J. Med. Virol. 81:1232–1240, 2009. © 2009 Wiley‐Liss, Inc.
Clinical evaluation of highly pathogenic tick‐borne flavivirus infection in the mouse model
Authors: Tigabu Bersabeh , Juelich Terry , Bertrand Joseph , Holbrook Michael R. 
Published: May 2009

AbstractThe objective of this study was to evaluate the feasibility of using clinical parameters to demonstrate disease progression and differentiate between Omsk hemorrhagic fever virus (OHFV) and Russian spring‐summer encephalitis virus (RSSEV) infection in the mouse model. Adult C57BL/6 and balb/c mice were infected with either OHFV or RSSEV by footpad inoculation and their temperature, body weight, clinical signs complete blood count, and blood chemistries were evaluated for up to 15 days post‐infection (dpi). Clinical evaluation showed that OHFV infection seriously affects balb/c mice, which had shorter average survival times (ASTs) than other groups. On the contrary, RSSEV infection of C57BL/6 mice was more severe than in balb/c mice. During these studies, the development of fever was not observed and the body weight of OHFV infected balb/c and C57BL/6 mice began to decline sharply starting from day 7 and 8, respectively, which correlated with disease onset. Peak increase of globulin and neutrophils was demonstrated after 9 dpi in OHFV infected mice; however, the lymphocyte number was not affected. Viremia was undetectable in these animals with either virus infection, but virus was found in most organs tested. These results indicate marked differences in the clinical signs, pathology, and immune response of mice infected with either OHFV or RSSEV and further validate the use of this mouse model system to evaluate human disease. J. Med. Virol. 81:1261–1269, 2009. © 2009 Wiley‐Liss, Inc.
Epidemiological study of genotypes of hepatitis B virus in northern Portugal
Authors: Mota Ana , Guedes Fátima , Areias Jorge , Pinho Luciana , Cardoso Margarida Fonseca 
Published: May 2009

AbstractWhile the overall prevalence of hepatitis B virus (HBV) infection in Portugal is around 1%, there are no published studies examining HBV genotypes in this country. This study aimed to survey HBV genotypes in the northern Portugal and to examine the possible associations between genotypes and gender, viral transmission routes, viral markers, viral load, and biochemical tests of liver function. The study sample consists of 340 patients with HBV infection of whom 42.9% were women. Tests were carried out for HBV genotypes and biochemical liver function while demographic information, including alcohol intake, was obtained from the patient files. The results indicate the predominance of genotype D (60.3%) and genotype A (31.5%). Intrafamilial transmission was predominant in female patients, while males were infected in equal proportions by perinatal, sexual, and intrafamilial transmission. Absence of HBeAg was found in a significantly smaller proportion of female patients with genotype D as compared to A (56.6% vs. 82.1%, P = 0.028). High viral load was associated significantly and independently with genotype D and HBeAg. Both alanine and aspartate aminotransferases (ALT and AST) were associated with gender and HBeAg. Thus, genotypes A and D were found to be the most prevalent in the north of Portugal. Patients infected with genotype D had higher levels of HBV DNA. HBeAg was associated with genotype D, viral load, and ALT and AST. J. Med. Virol. 81:1170–1176, 2009. © 2009 Wiley‐Liss, Inc.
Population‐based study on the seroprevalence of parvovirus B19 in Amsterdam
Authors: van Rijckevorsel G.G.C. , Sonder G.J.B. , Schim van der Loeff M.F. , van den Hoek J.A.R. 
Published: May 2009

AbstractA study was undertaken to estimate the seroprevalence of parvovirus B19 infection in the general adult population of Amsterdam, The Netherlands. To our knowledge this is the first study testing parvovirus B19 in a random sample of the Dutch adult population. The study was a cross‐sectional survey, and the study sample was stratified by age and ethnicity, with deliberate oversampling of minority ethnic groups. Serum samples obtained from 1,323 residents in 2004 were tested for antibodies to parvovirus B19. Basic demographic data (gender, age, country of birth, and number of children) were also available. Sixty‐two percent of the participants were seropositive; corrected for the oversampling the estimated prevalence in the Amsterdam adult population was 61%. No specific predictors or risk groups for seropositivity were identified. In our urban adult study population no positive correlation with increasing neither age, nor significant differences between age groups were found. These results imply that almost 40% of the adult Amsterdam population is susceptible to infection. J. Med. Virol. 81:1305–1309, 2009. © 2009 Wiley‐Liss, Inc.
Is managing the work–family interface worthwhile? Benefits for employee health and performance
Authors: van Steenbergen Elianne F. , Ellemers Naomi 
Published: May 2009

AbstractPast work–family research has shown that employees' work–family conflict experiences relate to adverse self‐reported health and performance outcomes, whereas work–family facilitation experiences relate positively to these self‐reports. The present research extends these findings by relating experiences in the work–family interface to objective health and performance indicators. We conducted two studies within a multinational financial services organization. The results of Study 1, a large‐scale cross‐sectional study (N = 1134), supported our hypotheses that conflict experiences relate to objective indicators of poor health (cholesterol level, body mass index, physical stamina), whereas facilitation experiences indicated better health. Study 2 (N = 58) was designed to longitudinally examine the relationship between employees' facilitation experiences and their objective physical health (cholesterol level, body mass index), actual sickness absence, and objective job performance over time. Corroborating our hypotheses, facilitation at Time 1 reliably predicted better physical health (cholesterol level and BMI), lower absenteeism, and increased job performance one year later (after correction for base‐line indicators). This research makes an important and much needed contribution to the literature and indicates that supporting employees to combine work and family roles not only enhances subjective well‐being of individual employees but also objectively benefits the organizations they work in. Copyright © 2009 John Wiley & Sons, Ltd.
Family friendly work practices, organizational climate, and firm performance: A study of multinational corporations in Hong Kong
Authors: Ngo Hang‐yue , Foley Sharon , Loi Raymond 
Published: May 2009

AbstractWe developed and tested a conceptual model to examine the impact of family friendly work practices (FFWPs) at the organizational level. In our model, top management support for equal opportunities is considered an antecedent of FFWPs and positive organizational climate, and firm performance and employee turnover are considered outcome variables. Structural equation modeling (SEM) was used to analyze the data collected from a sample of HR managers in multinational corporations (MNCs) in Hong Kong. The results showed that top management support for equal opportunities was positively related to a firm's level of FFWPs and organizational climate. In addition, FFWPs were positively related to organizational climate. We further found that organizational climate acted as a mediator between FFWPs and firm‐level outcomes. Copyright © 2009 John Wiley & Sons, Ltd.
Expert commentary on work–life balance and crossover of emotions and experiences: Theoretical and practice advancements
Authors: Westman Mina , Brough Paula , Kalliath Thomas 
Published: May 2009

AbstractProfessor Mina Westman, the head of Organisational Behaviour Program at the Tel Aviv is a leading international expert on the crossover of emotions and experiences in the family and the workplace. In this interview with Paula Brough and Thomas Kalliath (guest editors), Professor Westman clarifies the nature of two related constructs: Work–life balance and crossover. Work–life balance is the perception that work and non‐work activities are compatible and promote growth in accordance with an individual's current life priorities. Crossover focuses on how stress experienced by the individual influences strain experienced by the individual's spouse or team member. In this expert commentary, Professor Westman discusses the philosophical underpinnings of work–life balance, the significance of crossover of emotions and experiences for organizations and individuals, current advances in the field and sets out the new directions for this research. Copyright © 2009 John Wiley & Sons, Ltd.
A predictive study of emotional labor and turnover
Authors: Chau Samantha L. , Dahling Jason J. , Levy Paul E. , Diefendorff James M. 
Published: May 2009

AbstractThe current study examined how the emotional labor strategies of deep acting and surface acting directly influence emotional exhaustion and turnover intentions, and indirectly impact actual turnover among a sample of bank tellers. Turnover data were collected from organizational records 6 months after participants responded to a survey that measured emotional labor strategies, emotional exhaustion, and turnover intentions. Results showed that turnover intentions mediated the relationship between deep acting and actual turnover. Additionally, surface acting had indirect effects on turnover through emotional exhaustion and turnover intentions. Copyright © 2009 John Wiley & Sons, Ltd.
Emotions research in OB: The challenges that lie ahead
Authors: Gooty Janaki , Gavin Mark , Ashkanasy Neal M. 
Published: May 2009

AbstractWe discuss four challenges facing emotion scholarship in organizational behavior: (1) inconsistent definitions; (2) aggregation of discrete emotions into affective dimensions; (3) aggregation across time; and (4) failure to recognize the role of context. We discuss literature related to these challenges, and call for empirical research to address them. Copyright © 2009 John Wiley & Sons, Ltd.
Seasonal and inter‐annual variability of the moisture sources for Alpine precipitation during 1995–2002
Authors: Sodemann Harald , Zubler Elias 
Published: May 2009

AbstractThis study presents a first quantitative climatology of the moisture sources for precipitation in the European Alps, covering a 7‐year period from January 1995 to August 2002. Using a Lagrangian moisture source diagnostic and data from the ERA‐40: European Centre for Medium‐Range Weather Forecasts (ECMWF) reanalysis, the contribution of the following moisture sources to annual mean precipitation has been diagnosed: North Atlantic ocean 39.6%, Mediterranean 23.3%, North Sea and Baltic Sea 16.6%, and European land surface 20.8%. However, strong seasonal variability of the influence of various moisture sources is evident. Most notably, moisture transport to the Alps changes from an oceanic mode characterised by dominantly North Atlantic moisture sources during winter to a continental mode during summer with a marked contribution from Central European land areas. The method identifies inter‐annual variability with respect to the location of the moisture sources in the North Atlantic, and the importance of precipitation recycling during summer. Despite the smoothed Alpine orography in the ERA‐40 model, the Alps act as an effective barrier for meridional moisture transport, leading to distinct mean moisture source locations at their northern and southern slopes. The Northern Alps are predominantly influenced by the North Atlantic ocean and Central European land sources with a clear seasonality and limited monthly variability. In contrast, the Southern Alps receive a large fraction of precipitation from the Mediterranean with considerable month‐to‐month variability. Possible implications of these differences for precipitation extremes and stable isotopes in precipitation are discussed. Copyright © 2009 Royal Meteorological Society
Spatial and temporal variability of extreme precipitation in Poland in the period 1951–2006
Authors: Lupikasza Ewa 
Published: May 2009

AbstractThe study investigated spatial and temporal variability of extreme precipitation trend magnitudes and their directions. Daily precipitation from 48 synoptic stations in Poland for the period 1951‐2006 were used. Five indices of precipitation extremes were chosen: the highest 5‐day precipitation total, precipitation total from events ≥90th and 95th percentiles as well as number of days with precipitation ≥ 90th and 95th percentiles of daily precipitation amount. Trends in extreme precipitation indicators were analysed over semi‐annual periods as well as over the standard climatological seasons. Trends were calculated for each of the 30‐year moving periods within 1951‐2006 using a simple linear regression method. Their significance was tested with the Mann‐Kendall method.Decreasing trends in extreme precipitation indices dominated in both the warm and cool halves of the year and in the seasons. The greatest change was recorded in the least extreme precipitation indices. Summer was the season with the greatest number of statistically significant trends, mostly decreasing ones. Upward trends, having the greatest spatial extend in autumn, dominated the initial 30‐year periods of the study period whereas the decreasing trends were common in the 30‐years from 1956. In summer and winter, decreasing trends reached the greatest degrees of stability in southern Poland. In spring and autumn, a stable fall of extreme precipitation indices was mainly recorded in the south‐western part of the country. Stable increasing trends were recorded sporadically. However, in spring trends towards an increase were more frequent than in other seasons. The strongest decreasing trends were observed in summer and winter, mainly in the south, while in autumn they also occurred in the west. Copyright © 2009 Royal Meteorological Society
Relationship between monthly rainfall in northwest Iberian Peninsula and North Atlantic sea surface temperature
Authors: Lorenzo M. N. , Iglesias I. , Taboada J. J. , Gómez‐Gesteira M. 
Published: May 2009

AbstractThis study assesses the relationship between monthly North Atlantic sea surface temperature anomalies (SSTAs) and a regional index of rainfall (NWIPR) in northwest Iberian Peninsula during the period 1951–2006 by means of the Pearson product‐moment correlation. Results show a strong influence of SSTA on NWIPR in several months (February, April, May, October and December). The observed persistence of this influence up to 2‐months in advance can be used for monthly predictions of rainfall. The most significant areas of the North Atlantic were clustered to be used as input variables in linear regression models. Correlations up to 0.59 between observed and predicted rainfall anomalies were obtained. Predictability ranged from 76 to 86% when considering rainfall as a discrete predictand. Copyright © 2009 Royal Meteorological Society
A multicentury perspective on the summer North Atlantic Oscillation (SNAO) and drought in the eastern Atlantic Region
Authors: Linderholm Hans W. , Folland Chris K. , Walther Alexander 
Published: May 2009

AbstractThe summer North Atlantic Oscillation (SNAO) is strongly associated with July–August climate variability over Europe, especially in northern regions. This association includes drought, where a positive SNAO corresponds to dry conditions over much of northern Europe and wet conditions in southern Europe, but the SNAO/climate association is weaker and less homogeneous in the south. Here we use a dendroclimatological reconstruction of the SNAO for the last 550 a to investigate the SNAO/drought relationship in the past. An association between the SNAO and a regional summer drought index from Sweden suggests that the northern European drought relationship holds back to 1700. In the last 550 a, the relationship between SNAO and drought in the Mediterranean region as a whole is weak, but over the Eastern Mediterranean the relationship is clearer and statistically significant (P < 0.05 level). The Mediterranean relationship is clearest at century scales. An association between the SNAO and Sahel rainfall can clearly be seen on interannual as well as longer timescales in the 20th century. Past droughts in the Sahel, as inferred from historical data, correspond quite well with positive phases of the SNAO on multidecadal timescales back to 1500, the phase expected from instrumental data. The physical reasons for the relationship between Sahel rainfall and the SNAO are, however, not yet understood. This research is a first step towards understanding how the atmospheric circulation over the North Atlantic region affects drought, necessary for forecast future droughts. Copyright © 2009 John Wiley & Sons, Ltd. and © Crown Copyright 2009.