bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Salivary Micro RNAs as a Diagnostic Marker in Early Detection of Oral Squamous Cell Carcinoma
Authors: Munwar Baloch  , Sana Javed Khoso  , Saima Saman  , Sajid Ali Majeedano  , Muhammad Aqeel  , Faiz Muhammad Khoso  
Published: May 2024

OBJECTIVE: To assess the diagnostic role of salivary microRNA for early detection oforal squamous cell carcinoma and to compare the salivary microRNA with Biopsy in thediagnosis of oral squamous cell carcinoma.Methodology: The descriptive cross-sectional study was conducted in the department of pathology and molecular laboratory, department of oral &amp; maxillofacial surgery of Liaquat University of Medical Health Sciences, Jamshoro / Hyderabad.Inclusion Criteria: All histopathologicaly diagnosed OSCC patients of both genders with age group 18 years and above will be included in the study after taking their informed consent. Whole saliva samples (inactivated) were collectedfrom subjects diagnosed as OSCC and controls. The subjects were counseled to avoid eating, drinking, smoking or oral procedures for at least 1 h prior to the collection of saliva. Subjects are asked to rinse their mouth well with distilled drinking water for one minute before taking the saliva samples. After five minutes of oral rinsing spit 5 mL of saliva into a 50 mL sterile tube placed on the ice. The tube should remain on ice while collecting the saliva samples. Fourhundred microliters of the whole saliva mixture (200 ?L whole saliva and 200 ?L RNA later),and 400 ?L of the supernatant saliva was used for RNA extraction. Saliva samples wereextracted using the mirVana™ miRNA Isolation Kit according to the manufacturer&#39;s guideline(Ambion Inc., Austin, TX). Whole saliva samples were preserved with RN Alater (QIAGENInc., Valencia, CA) and supernatant saliva samples were preserved with SUPE Rase. In™ (Ambion Inc., Austin, TX). The data was entered in the statistical package for social sciences for windows (SPSS) V: 26.RESULTS: A total of 120 samples of oral squamous cell carcinoma were taken, which met theinclusion criteria. Mean age of the patients was 47.45+10.85 years. 85(70.8%) were married and35 (29.2%) were unmarried. 90.0% were married and 5.0% were unmarried, while 5.0% werewidow. Cigarette smoking, paan, chaalia and naswar were the commonest cause of the oralsquamous cell carcinoma. Lips, buccal mucosa and tong were the commonest t sites of the oralsquamous cell carcinoma. 16.7% cases had positive family history of oral squamous cellcarcinoma. Out of all study subjects, most of the cases 59.2% had moderately differentiatedSCC, 30.0% cases had well-differentiated SCC and 10.8% of the cases had poor differentiatedSCC. Out of all study subjects, 87.5% of the patients had positive micro-RNA expression.Micro-RNA expression was significantly associated, with poorly differentiated squamous cellcarcinoma (p=0.016).
CONCLUSION: Study revealed that the salivary miroRNA expression were significantlypositive in patients of OSCC. Therefore, salivary microRNA could be considered as a useful andadvantageous biomarker for the detection and tracking of OSCC across various levels of tissueabnormalities
ĐẶC ĐIỂM KÍCH THƯỚC, CHỨC NĂNG THẬN VÀ QUAN ĐIỂM LỰA CHỌN THẬN HIẾN TRONG GHÉP THẬN TỪ NGƯỜI CHO SỐNG CÙNG HUYẾT THỐNG TẠI BỆNH VIỆN HỮU NGHỊ VIỆT ĐỨC
Authors: Lê Nguyên Vũ , Nguyễn Quang Nghĩa 
Published: May 2024

Mục tiêu: Đánh giá đặc điểm kích thước thận trên MSCT, chức năng thận trên xạ hình với 99mTcDTPA và cách chọn thận hiến của người hiến thận cùng huyết thống. Đối tượng và phương pháp: Nghiên cứu mô tả, cắt ngang trên 84 người bình thường, khỏe mạnh có cùng huyết thống với người nhận thận, sau khi làm mức lọc cầu thận 24h đạt được đánh giá hình thái thận qua MSCT 256 dãy và làm xạ hình với 99mTcDTPA, từ tháng 01/2021 - 4/2022. Kết quả: Độ tuổi hiến thận thấp nhất là 30 tuổi, cao nhất là 64 tuổi, TB ± SD là 49,49 ± 7,44. Người hiến có độ tuổi từ 41 – 60 là chủ yếu, chiếm tỷ lệ 82,15%. Tỷ lệ nam/nữ ở người hiến thận là 25/59. Đa số các trường hợp, mẹ sẽ là người tình nguyện hiến thận cho con ruột, chiếm tỷ lệ 54,76%. Tỷ lệ cha hiến thận cho con (23,81%) và anh chị em hiến thận cho nhau (21,43%) là tương đối bằng nhau. Kích thước của thận trên MSCT 256 dãy là: Thận phải nam 100,64 ± 7,58 mm, nữ: 100,05 ± 8,36 mm, thận trái nam 100,5 ± 11,03 mm, nữ 103,00 ± 11,51 mm. Kích thước thận hiến 100,1 ± 7,79 mm, thận để lại: 102,35 ± 8.89 mm. Chức năng thận trên xạ hình với 99mTcDTPA, mức lọc cầu thận trung bình ở cả hai giới 113,26 ± 14,91 mL/phút; thận phải 55,73 ± 8,02 mL/ phút, thận trái 57,53 ± 7,78 mL/phút; tỷ lệ % chức năng thận hiến: 48,43 ± 1,92 (%), thận để lại: 51,57 ± 1,92 (%). Không có mối tương đồng giữa mức lọc cầu thận trên xạ hình thận và công thức ước tính. Kết luận: Kích thước thận trên cắt lớp vi tính và xạ hình chức năng thận có ý nghĩa quan trọng trong lựa chọn thận hiến thận. Việc chọn thận hiến được cá thể hóa trên nhiều yếu tố.
Shallow- and deep-convection characteristics in the greater Houston, Texas, area using cell tracking methodology
Authors: Tuftedal Kristofer S. , Treserras Bernat Puigdomènech , Oue Mariko , Kollias Pavlos 
Published: May 2024

Abstract. The convective lifecycle, from initiation to maturity and dissipation, is driven by a combination of kinematic, thermodynamic, microphysical, and radiative processes that are strongly coupled and variable in time and space. Weather radars have been traditionally used to provide various convective-cloud characteristics. Here, we analyzed climatological convective-cell radar characteristics to obtain and assess the diurnal cycles of three convective-cell types – shallow, modest deep, and vigorous deep convective cells – that formed in the greater Houston area, using the National Weather Service radar from Houston, Texas, and a multi-cell identification and tracking algorithm. The examined dataset spans 4 years (2018–2021) and covers the warm-season months (June to September) in those years. The analysis showed clear diurnal cycles in cell initiation (CI) consistent with the sea breeze circulation and showed diurnal and normalized lifetime relationships in cell evolution parameters (e.g., maximum reflectivity, echo-top height, Geostationary Operational Environmental Satellite-16 (GOES-16) channel 13 brightness temperature, and the height of maximum reflectivity). The cell evolution is well represented by relationships between (1) the height and value of the maximum radar reflectivity, (2) the minimum GOES-16 channel 13 brightness temperature and the maximum vertically integrated liquid, (3) the maximum reflectivity and columnar-average reflectivity, and (4) the echo-top ascent rate and cell lifetime. The relationships presented herein help to identify the cell lifecycle stages such as early shallow convection, vigorous vertical development, anvil development, and convective core dissipation. GOES-16 Aerosol Optical Depth values are also used as a proxy for cell initiation aerosol concentrations to investigate any potential relationships between initiation location and aerosol concentration. Overall, no significant relationships between initiation location and aerosol concentration were found for the three cell types investigated, but there are some minor differences in the pre-CI aerosol optical depth for vigorous deep convective cells.
Mechanisms of global ocean ventilation age change during the last deglaciation
Authors: Li Lingwei , Liu Zhengyu , Du Jinbo , Wan Lingfeng , Lu Jiuyou 
Published: May 2024

Abstract. Marine radiocarbon (14C) is widely used to trace deep-ocean circulation, providing insight into the atmosphere–ocean exchange of CO2 during the last deglaciation. Evidence shows a significantly depleted Δ14C in the glacial deep ocean, suggesting an increased ventilation age at the Last Glacial Maximum (LGM). In this study, using two transient simulations with tracers of 14C and ideal age (IAGE), we found that the oldest ventilation age is not observed at the LGM. In contrast, the models show a modestly younger ventilation age during the LGM compared to the present day. The global mean ventilation ages averaged below 1 km are approximately 800 (630) years and 930 (2000) years at the LGM and in the present day, respectively, in two simulations. This younger glacial ventilation age is mainly caused by the stronger glacial Antarctic Bottom Water (AABW) transport associated with sea ice expansion. Notably, the ocean ventilation age is significantly older predominantly in the deep Pacific during deglaciation compared to the age at the LGM, with global mean ventilation ages peaking at 1900 and 2200 years around 14–12 ka in two simulations, primarily due to the weakening of AABW transport.
Quantifying the impact of SST feedback frequency on Madden–Julian oscillation simulations
Authors: Lan Yung-Yao , Hsu Huang-Hsiung , Tseng Wan-Ling 
Published: May 2024

Abstract. This study uses the Community Atmosphere Model 5.3 coupled to a 1-D ocean model to investigate the effects of intraseasonal sea surface temperature (SST) feedback frequency on Madden–Julian oscillation (MJO) simulations with intervals at 30 min and 1, 3, 6, 12, 18, 24, and 30 d. The large-scale nature of the MJO in simulations remains intact with decreasing feedback frequency, although it becomes increasingly unrealistic in both structure and amplitude, until 1 per 30 d when the intraseasonal fluctuations are overwhelmingly dominated by unorganized small-scale perturbations in both atmosphere and ocean, as well as at the atmosphere–ocean interface where heat and energy are rigorously exchanged. The main conclusion is that the less frequent the SST feedback, the more unrealistic the simulations. Our results suggest that more spontaneous atmosphere–ocean interaction (e.g., ocean response once every time step to every 3 d in this study) with high vertical resolution in the ocean model is a key to the realistic simulation of the MJO and should be properly implemented in climate models.
OVERVIEW OF THE POSITIONS OF THE INTERNATIONAL COMMUNITY ON THE REFORM OF THE UN SECURITY COUNCIL OF THE UNITED NATIONS
Authors: ФИРСОВ Ю.И. 
Published: May 2024

Совет Безопасности Организации Объединенных Наций (СБ ООН) является ведущим органом в системе ООН, имеющим полномочия по формированию и установлению международного правопорядка и принятию решения в области международной безопасности. Конкуренция на международной арене и геопо- литика оказывают влияние на международный правопорядок и безопасность. Со времени Карибского кризиса вопрос о полномочиях и реформировании СБ ООН стал актуальным. В статье рассмотрены позиции ряда стран и международных организаций по вопросу реформирования СБ ООН. Актуальность темы обусловлена ролью Организации Объединенных Наций в современных международных отношениях в связи с их неопределенно- стью, в результате которой у участников международных отношений сформировались свои принципы между- народного права. В статье проводится сопоставительный анализ позиций государств, групп государств и международных ор- ганизаций по вопросу о реформе ООН, констатируется необходимость дальнейшего укрепления сотрудничества участников международных отношений в интересах реформирования СБ ООН и будущего мироустройства.
The UN Security Council is the leading body in the UN system with the authority to form and establish the international legal order and make decisions in the field of international security. Competition in the international arena and geopolitics have an impact on international law and order and security. Since the Caribbean crisis, the issue of the powers and reform of the UN Security Council has become relevant. The article examines the positions of a number of countries and international organizations on the issue of reforming the UN Security Council. The relevance of the topic is due to the role of the United Nations in modern international relations. Due to the uncertainty in modern international relations, as a result of which the participants in international relations have formed their own principles of international law. The article provides a comparative analysis of the positions of states, groups of states and international organizations on the issue of UN reform and states the need to further strengthen cooperation among participants in international relations in the interests of reforming the UN Security Council and the future world order.
CONVICTED MINORS AS AN OBJECT OF CRIMINAL LAW AND PENITENTIARY RESEARCH
Authors: КОСТЮК М.Ф. , КУНЦ Е.В. 
Published: May 2024

Преступность молодеет и приобретает устойчивый рецидивный и повторный характер. Крими- нализация лиц подросткового возраста, молодёжи лишает общество перспективы социального благополучия и стабильности. Основной причиной того, что несовершеннолетние идут на преступления, является их неспособ- ность анализировать серьезность действий и то, что зачастую они ассоциируют свои поступки с увлекательной игрой. В связи с этим актуально вести речь о профилактике правонарушений несовершеннолетних, а также достижении главной цели наказания – исправления несовершеннолетнего осужденного и предупреждения со- вершения новых преступлений.
Crime is getting younger and acquiring a stable relapse and repeat character. The criminalization of adolescents and young people deprives society of the prospects for social well-being and stability. The main reason that minors commit crimes is their inability to analyze the seriousness of actions and the fact that they often associate their actions with an exciting game. In this regard, it is important to talk about the prevention of juvenile delinquency, as well as achieving the main goal of punishment – the correction of a convicted minor and the prevention of the commission of new crimes.
SIKAP PASANGAN DALAM MENGHADAPI PERUBAHAN PSIKOLOGIS WANITA MENOPAUSE KECAMATAN LARANGAN PAMEKASAN
Authors: Fauziyah Susilawati Endang 
Published: May 2024

Periode menopause memungkinkan wanita dapat mengalami perubahan psikologis pada.Wanita menopause yang sangat terganggu psikologisnya besar kemungkin karena kurang mempunyai informasi yang benar mengenai seluk beluk menopause. Tujuan penelitian ini untuk mengetahui persepsi pasangan terhadap perubahan psikologis pada wanita yang telah menopause. Penelitian ini menggunakan metode deskriptif, dengan populasi dan jumlah sampel 23 responden yaitu seluruh suami yang mempunyi pasangan menopause dengan teknik total sampling. Pengambilan data dengan menggunakan questioner Tipe Skala Likert serta dianalisa secara deskriptif dan disajikan dalam bentuk tabel dan narasi. Berdasarkan hasil penelitian didapatkan bahwa responden hampir seluruhnya menunjukkan sikap mendukung terhadap sikap psikologis pasangannya sebanyak 14 orang (60%) dan dan yang menunjukkan sikap kurang mendukung sebanyak 9 orang (39%). Perlu diadakan beberapa penyuluhan pada pasangan menopause sebagai tambahan informasi, dan juga perlu adanya komunikasi yang baik antara suami dan istri.
A klinikai gyógyszerész szerepe az elektronikus gyógyszeradminisztrációban
Authors: Bertalan Ádám , Dinya Elek 
Published: May 2024

A tanulmány a klinikai gyógyszerészek szerepét mutatja be az elektronikus gyógyszeradminisztrációs rendszer bevezetésében és működtetésében a Mosonmagyaróvári Karolina Kórház - Rendelőintézetben. A gyógyszeres terápia hatékonyságának és biztonságának növelése az egészségügyi ellátórendszer minden résztvevőjének jól felfogott érdeke. Kórházunkban a 20 éves múltra visszatekintő centralizált betegszintű gyógyszerelési folyamatának digitális adminisztrációval történő modernizálását tűztük ki célul. Az 1960-as évek óta bizonyított tény, hogy a gyógyszerészek bevonása a gyógyszeres terápia összeállításába és felülvizsgálatába pozitív hatást gyakorol a betegellátás hatékonyságára. A közlemény bemutatja a klinikai gyógyszerészek osztályos tevékenységét, és a gyógyszerelés folyamatát. Az új e-lázlap segítségével naponta 70-90 beteg gyógyszerelését rögzítettük digitálisan, jelentősen csökkentve a gyógyszerelési hibák és ezáltal a gyógyszerek okozta problémák valószínűségét. A papír alapú adminisztrációval összehasonlítva az e-lázlappal sikerült kiküszöbölnünk az adminisztrációs hibák 92%-át a gyógyszerelrendelés folyamatában. A mérhető eredményeink alapján leszögezhetjük, hogy a klinikai gyógyszerészek kulcsszerepet töltöttek be a fejlesztés végrehajtásában és a folyamat fenntartásában egyaránt. A projektben az eredeti célon túlmutatóan gyógyszeradminisztráció mellett a gyógyszerészi kompetenciát is sikeresen terjesztettük ki azáltal, hogy a szükséges gyógyszerészi jelenlét magával hozta a gyógyszerészi revízió, és részben a gyógyszerelés egyeztetés kivitelezésének lehetőségét is.
Vitamin E Cup Cross-linked Polyethylene in Total Hip Arthroplasty: A Meta-analysis of Randomized Controlled Trials
Authors: Lamo-Espinosa José María , Mariscal Gonzalo , Gómez-Álvarez Jorge , San-Julian Mikel 
Published: May 2024

Introduction:
The goal of this study was to assess the efficacy and safety of vitamin E cup cross-linked polyethylene (VEPE) liners compared with standard polyethylene (PE) liners in total hip arthroplasty.

Methods:
A systematic search of the PubMed, EMBASE, Scopus, and Cochrane Collaboration Library databases was conducted. The evaluated outcomes were radiological parameters, functional scores (Harris Hip Score, Numeric Rating Scale, and Activity Scale from the University of California), and adverse events. Odds ratios and mean differences (MD) were calculated for the dichotomous and continuous variables. Meta-analysis was done using Review Manager.

Results:
Seven randomized controlled trials (n = 990) were included. VEPE liners showed markedly lower penetration at the last follow-up (MD, −0.15; 95% confidence interval [CI], −0.18 to −0.11) and penetration rate at last follow-up (MD, −0.01; 95% CI, −0.01 to −0.00) than standard PE liners. However, no notable differences were observed in cup migration, inclination, anteversion, or patient-reported outcomes. The complication rate was not markedly different between the groups (odds ratio, 1.07; 95% CI, 0.42 to 2.73).

Discussion:
This meta-analysis found that while VEPE demonstrated decreased penetration rates in total hip arthroplasty, no differences were observed in patient outcomes or complications compared with standard PE. However, the clinical relevance of penetration rate reduction remains uncertain, given the short follow-up period.
Prevalence and risk factors of depression among patients with perianal fistulizing Crohn’s disease
Authors: Li Jing , Ng Wing-Yi , Qiao Li-Chao , Yuan Fen , Lan Xing , Zhu Li-Bei , Yang Bo-Lin , Wang Zhong-Qiu 
Published: May 2024

BACKGROUND
Psychological distress, especially depression, associated with perianal fistulizing Crohn’s disease (PFCD) is widespread and refractory. However, there is a surprising paucity of studies to date that have sought to identify the prevalence and risk factors of depression associated with PFCD.
AIM
To estimate the prevalence of depressive symptoms and investigate the depression-related risk factors in patients with PFCD.
METHODS
The study was conducted in the form of survey and clinical data collection via questionnaire and specialized medical staff. Depressive symptoms, life quality, and fatigue severity of patients with PFCD were assessed by Patient Health Questionnaire-9, Inflammatory Bowel Disease Patient Quality of Life Questionnaire (IBDQ), and Inflammatory Bowel Disease (IBD) Fatigue Patient Self-assessment Scale. The basic demographic information, overall disease features, perianal clinical information, and laboratory inflammation indicators were also gathered. Multivariate regression analysis was ultimately used to ascertain the risk factors of depression associated with PFCD.
RESULTS
A total of 123 patients with PFCD were involved, and 56.91% were suffering from depression. According to multivariate logistic regression analysis, Perianal Disease Activity Index (PDAI) score [odds ratio (OR) = 0.69, 95% confidence interval (CI): 0.50 to 0.95], IBDQ score (OR = 0.93, 95%CI: 0.88 to 0.97), modified Van Assche index (OR = 1.24, 95%CI: 1.01 to 1.53), and IBD Fatigue score (OR = 1.72, 95%CI: 1.23 to 2.42) were independent risk factors of depression-related prevalence among patients with PFCD (P < 0.05). Multiple linear regression analysis revealed that the increasing perianal modified Van Assche index (β value = 0.166, 95%CI: 0.02 to 0.31) and decreasing IBDQ score (β value = -0.116, 95%CI: -0.14 to -0.09) were independently associated with the severity of depression (P < 0.05).
CONCLUSION
Depressive symptoms in PFCD patients have significantly high prevalence. PDAI score, modified Van Assche index, quality of life, and fatigue severity were the main independent risk factors.
Efeito dos diversos tênis de corrida no desempenho e na prevenção de lesões em corredores de meia-maratona e maratona
Authors: Lima Vitor Rodrigues Pacheco de , Cavalcante Diego Vinícius Duarte , Borges José Alex Almeira , Andrade Samanta Gomes Lima de , Silva Taís Feitosa da 
Published: May 2024

A corrida de rua vem ganhando cada vez mais adeptos e com isso as marcas investem em tecnologias que prometem melhorar o desempenho e evitar lesões. A partir disso, o objetivo deste estudo é identificar quais os efeitos do calçado de corrida no desempenho e na prevenção de lesões em corredores de meia-maratona e maratona. Para isso, foi feita uma revisão integrativa da literatura, na qual foram analisados 16 artigos originais, em língua portuguesa, utilizando os descritores: Corrida de longa distância, desempenho, lesão, economia da corrida e tênis. Os artigos incluídos foram dos últimos 10 anos, além de avaliarem corredores amadores de longas distâncias com idade entre 18 e 40 anos. Dos artigos encontrados, 4 falam sobre a análise das tecnologias na corrida; 9 abordam o tema: corrida e lesões; 1 estudou sobre a escolha dos calçados e lesões e 2 analisaram os calçados. Em conclusão, percebeu-se que os atletas são influenciados pelas marcas e grandes atletas da modalidade. Além disso, não foram observadas diferenças significativas no ganho de desempenho relacionadas ao tênis, e sim características físicas, como a altura, percentual de gordura e o peso. O que se encontrou foi uma melhor economia de energia e amortecimento utilizando um tênis com maior entressola. No que diz respeito às lesões, elas têm aumentado entre os corredores, e os fatores observados foram: idade, gênero e características antropométricas, do treino e do tênis. Além de ocasionar entorse de tornozelo, favorecidas pela instabilidade do calçado.
Organizational work and adoption of standards of the All-Russian Sports Society “Ready for Labor and Defense” (GTO) in an educational organization
Authors: Svetlakova M. V. , Markova S. V. , Panshina S. A. 
Published: May 2024

Relevance. Currently, the competence of health-saving behavior is indicated in all areas of educational activity. It correlates with the upbringing of the younger generation of a health culture, which means not only health literacy, but also the practical embodiment of the need to lead a healthy lifestyle, take responsibility for yourself and take care of your own health. Methods and organization of research are the essence of aspects of health-saving pedagogy, according to which the consistent formation of a healthy environment at school, college, and institute involves the use and possession by teachers of technologies that do not harm health. The results of the study. For the first time, such a large-scale event was held, where teachers of the Yekaterinburg Institute of Physical Culture, together with the judging panel of the Kalininets Sports and Recreation Complex, conducted a Sports quest, and participants in the quest to fulfill the standards of the TRP were both students of the college and the Institute of Physical Culture, as well as physical education teachers of schools in Yekaterinburg. Conclusions: The focus of attention when introducing the WFSK TRP into the education system should be not only the actual preparation for the implementation of standards, but also the formation of a physical culture of the individual, which is advisable to carry out through spiritual and moral, patriotic education and tourism and local history activities as an element of spiritual, moral and patriotic education.