bluuebunny/crossref_metadata_2025_split huggingface dataset:
Results of epistaxis embosurgery using detachable platinum fibered coils
Authors: Lesley Walter S , Rangaswamy Rajesh , Patel Delip V 
Published: June 2010

BackgroundSafety and efficacy outcomes are lacking for embosurgery of the distal internal maxillary artery (IMax) using detachable platinum fibered coils (DPFCs) in patients with uncontrollable epistaxis.MethodsA retrospective analysis was conducted on patients treated October 2006 through May 2009 with a diagnosis of uncontrollable or recurrent epistaxis managed by DPFC. Inclusion criteria included patients with epistaxis complicating open or endoscopic nasal surgery, or patients with the following covariant risk factors: aspirin, clopidogrel, warfarin, ibuprofen or hypertension. Patients were excluded if particulates, liquid glue or non-permanent embolics were used as adjuvants. Medical record review and follow-up for 1 month were performed on all patients to determine treatment results and complications.ResultsA cohort of 20 patients meeting enrollment criteria was comprised of 13 men and 7 women with a mean age of 63 years (range 35–85 years). Epistaxis etiologies included recent nasal surgery (N=2) while all patients (N=20) had one or more covariant epistaxis risk factors. 17 patients underwent bilateral IMax embolization. Three patients had unilateral IMax embosurgery in which two patients had a remote history of contralateral IMax open ligation for previous epistaxis. 95% of the cohort remained free of recurrent nose bleeding requiring medical or surgical intervention. 95% of the patients had no complications while one patient (5%) had transient unilateral facial pain. There was no procedure-related death, blindness or stroke. One patient died during follow-up from unrelated causes.ConclusionDPFC embosurgery is effective and safe in managing uncontrollable epistaxis.
Intra-arterial abciximab for the treatment of thrombus formation during coil embolization of intracranial aneurysms
Authors: Linfante Italo , Etezadi Vahid , Andreone Vincenzo , DeLeo Michael , Alehashemi Sara , Shaw Kate , Wakhloo Ajay 
Published: June 2010

Background and purposeThrombus formation during endovascular embolization of intracranial aneurysms occurs in 2.9%–6% of patients. Use of IIb/IIIA inhibitors such as abciximab or eptifibatide intravenously has been reported in management of this complication. Because the intra-arterial infusion of IIb/IIIA inhibitors may require lower doses to achieve thrombolysis, it may reduce the risk of haemorrhage. Therefore, we retrospectively analyze our database and review the literature.MethodsThis is a retrospective analysis of a prospectively acquired database of patients with ruptured or unruptured aneurysm treated intra-arterially for thrombus formation during endovascular coil embolization between July 2005 and August 2008. Patient demographics, aneurysmal characteristics, procedural, clinical outcome and complications were recorded.ResultsFrom July 2005 to August 2008, out of 184 patients who underwent coil embolization, 19 patients (15 smokers, 14 female, mean age 52) developed intraprocedural thrombus formation and received intra-arterial abciximab treatment. Mean aneurysm size was 6.6 mm±4.9 mm; neck size was 3.8 mm±2.1 mm. Eight (42.1%) aneurysms were ruptured. Most aneurysms (63.1%) were in anterior communicating and middle cerebral arteries. Thrombus was visualized in all cases by angiogram and treated intra-arterially with a mean dose of 10.5 mg±4.2. There were no periprocedural hemorrhagic complications. No deaths or other complications occurred during follow-up.ConclusionThrombus formation during coil embolization of intracranial aneurysms occurred more in women and smokers. Low doses of intra-arterial abciximab may be effective in the thromboembolic complications occurring during endovascular embolization of intracranial aneurysms.
Associations of SRAP markers with dried-shrink disease resistance in a germplasm collection of sea buckthorn (Hippophae L.)
Authors: Li He , Ruan Cheng-Jiang , Teixeira da Silva Jaime A. , Liu Bao-Quan 
Published: June 2010

Sea buckthorn ( Hippophae L.) is a woody, outcrossing dioecious pioneer plant, being widely planted as a new berry crop with rich nutritional and medicinal compounds. This long-juvenile and long-lived woody plant can be more difficult to cultivate than other crop plants. Dried-shrink disease (DSD) is a dangerous pathogen that destroys sea buckthorn and halts commercial production. We estimated variability of sequence-related amplified polymorphism (SRAP) markers in 77 accessions of 22 sea buckthorn cultivars to seek markers associated with DSD resistance and help to identify potential breeding cultivars. Seventeen SRAP primer combinations generated 289 bands, with a mean of 17 bands per primer combination. At a Dice coefficient of 0.852, the dendrogram generated with 191 polymorphic bands clustered 73 accessions of Hippophae rhamnoides into 2 groups and 4 accessions of Hippophae salicifolia into 1 group. Eleven SRAP markers (Me1-Em3600, Me1-Em1680, Me2-Em1650, Me2-Em1950, Me3-Em61300, Me2-Em6320, Me2-Em6400, Me1-Em2600, Me1-Em11200, Me1-Em11700, Me2-Em2250) were significantly correlated with DSD resistance (P < 0.001). These markers provide a viable option for breeding programs that select lineages with DSD resistance, especially when no other genetic information, such as linkage maps and quantitative trait loci, are available.
Numerical investigation of the response of expansion anchors used to attach helical pile connectors to concrete foundations
Authors: El Sharnouby M.M. , El Naggar M.H. 
Published: June 2010

This paper evaluates the performance of expansion anchors used to attach helical pile connectors to foundations. The anchors’ response to pullout loads was evaluated using nonlinear finite element analysis with the aid of the commercial software, Abaqus. The connector capacity under horizontal movement of the foundation for different anchor diameters, embedment depths, and anchors’ spacing is reported. It was found that the pre-tension load had no influence on the anchor ultimate capacity, but affected the anchor response at service load levels and the displacement at failure. Under pullout loading, increasing the anchor diameter resulted in a more brittle response, but did not affect the ultimate capacity when the concrete tensile strength dominated the response. No interaction between anchors was observed for spacing ≥ 1.67 times the anchor’s embedment depth. A modification to the helical pile connector configuration is proposed.
Physical and computational modelling of residence and flow development time in a large municipal disinfection clearwell
Authors: Yu Xiaoli , Mazurek Kerry Anne , Putz Gordon , Albers Cory 
Published: June 2010

In this study, a two-dimensional, depth-averaged computational model (River2DMix) was used to predict the flow pattern and residence time distribution for flow through the Calgary Glenmore Water Treatment Plant northeast clearwell. Results are compared to those from flow visualization and tracer studies in a 1 : 19 scale model of the clearwell, as well as tracer studies conducted at the plant. Tests were carried out for three flow rates that ranged from minimum to maximum operating conditions. A key observation in the physical model was that it was necessary to let the flow fully develop before starting a tracer test to determine the residence time distribution. This flow development time to achieve steady-state results was approximately 10.5 h at the minimum flow rate tested. Results also show that it was unnecessary to model the structural columns either in the simulation or the scale model for developed flow in this clearwell, although for undeveloped or transient flow conditions the columns were important to consider.
Mycovirus inPseudocercospora griseola, the causal agent of angular leaf spot in common bean
Authors: Lima Swiany Silveira , Abadio Ana Karina Rodrigues , Araújo Elza Fernandes , Kitajima Elliot Watanabe , Sartorato Aloísio , Vieira de Queiroz Marisa 
Published: June 2010

Pseudocercospora griseola (Sacc.) Crous & Braun is a widespread fungal phytopathogen that is responsible for angular leaf spot in the common bean ( Phaseolus vulgaris L.). A number of fungal phytopathogens have been shown to harbour mycoviruses, and this possibility was investigated in populations of Pseudocercospora griseola. The total nucleic acid extracts of 61 fungal isolates were subjected to agarose gel electrophoresis. Small fragments (800–4800 bp) could be identified in 42 of the samples. The presence of dsRNA in isolate Ig838 was confirmed by treatment of total nucleic acid with DNase, RNase A, and nuclease S1. Transmission electron microscopy revealed the presence of viral-like particles 40 nm in diameter in the mycelia of 2 fungal isolates, namely 29-3 and Ig838. The transmission of dsRNA by means of conidia was 100% for isolate 29-3, but there was loss of 1–6 fragments of dsRNA in monosporic colonies of isolate Ig848. Cycloheximide treatment failed to inhibit the mycovirus in isolate 29-3, but proved efficient in the elimination of the 2.2, 2.0, 1.8, 1.2 and 1.0 kb fragments in 2 colonies of isolate Ig848. The occurrence of a mycovirus in Pseudocercospora griseola was demonstrated for the first time in the present study.
Intragastric immunization of mice with enterohemorrhagicEscherichia coliO157:H7 bacterial ghosts reduces mortality and shedding and induces a Th2-type dominated mixed immune response
Authors: Cai Kun , Gao Xiang , Li Tao , Hou Xiaojun , Wang Qin , Liu Hao , Xiao Le , Tu Wei , Liu Yuenan , Shi Jing , Wang Hui 
Published: June 2010

A bacterial ghost (BG)-based vaccine was developed against enterohemorrhagic Escherichia coli O157:H7 infection. The aim of this study was to evaluate the protective effect of E. coli O157:H7 BGs in a mouse model and to reveal the mechanism of the immune response. Booster immunization provided a higher protection rate (84%) than single-dose immunization (56%). Intragastric immunization of E. coli O157:H7 BGs induced both humoral and cellular immune responses. The proliferative response of CD4+T cells was mediated by the antigen-presenting cells. The humoral immune response dominated the immune response, while the cellular immune response developed later. Inflammatory reaction was balanced by the mixed Th1/Th2 immune response. The immune sera anti-adhesion effect was confirmed by the inhibition effect, which could inhibit >90% of the adhesion of E. coli O157:H7 to Hep-2 target cells in vitro. Antibody titer specific for intimin, a molecule important for adhesion of E. coli O157:H7 to target cells, correlated with specific immunoglobulin A or G antibody titer. Therefore, it might be feasible to clinically test BG vaccines in the future.
Microbial community characterization of the Gully: a marine protected area
Authors: Yeung C. William , Lee Kenneth , Whyte Lyle G. , Greer Charles W. 
Published: June 2010

The Gully is the first Fisheries and Oceans Canada marine protected area off the eastern coast of Canada. To ensure success of conservation efforts in this area, it is essential to develop a better understanding of microbial community composition from the euphotic zone to the deep sea in this previously unsurveyed environment. Denaturing gradient gel electrophoresis (DGGE) and nucleotide sequencing were used to characterize microbial community structure. DGGE results showed a clear difference in the microbial community structure between the euphotic zone and the deep sea water. Cluster analysis showed high similarity (>85%) for all the samples taken from below 500 m, but lower similarity (49%–72%) when comparing samples from above and below 500 m. Changes in microbial community structure with depth corresponded well with changes in oceanographic physical parameters. Furthermore, 16S rRNA gene analysis showed that the bacterioplankton sequences generally clustered into 1 of 9 major lineages commonly found in marine systems. However, not all the major lineages were detected at all the different depths. The SAR11 and SAR116 sequences were only present in the surface water, and the SAR324 and Actinobacteria sequences were only present in deep sea water. These findings provide a preliminary characterization of the microbial communities of this unique ecosystem.
Exacerbation of acute viral myocarditis by tobacco smoke is associated with increased viral load and cardiac apoptosis
Authors: Bae Soochan , Ke Qingen , Koh Young Youp , Lee Wooseung , Choi Jun H. , Kang Peter M. , Morgan James P. 
Published: June 2010

Exposure to tobacco smoke is known to have deleterious cardiovascular effects. In this study, we tested whether exposure to tobacco smoke exacerbates the severity of viral myocarditis in mice. Viral myocarditis was generated in 4-week-old male BALB/c mice by injection of Encephalomyocarditis virus (EMCV). Four groups were studied: (1) control (C, no smoke and no virus); (2) smoke only (S, exposure to cigarette smoke for 90 min/day for 15 days); (3) virus only (V); and (4) exposure to smoke for 5 days before plus 10 days following virus injection (S+V). We found that viral inoculation preceded by smoke exposure increased mortality more than twofold compared with virus inoculation alone. In addition, the mRNA level of atrial natriuretic factor was significantly higher in S+V than among any of the other 3 groups. Virus injection significantly decreased cardiac function compared with controls, with further deterioration observed in the S+V group. We also observed a significantly increased rate of apoptosis, with an increased activation of apoptosis-inducing factor in hearts exposed to S+V compared with those exposed to V alone. Our results suggest that preexposure to smoke significantly exacerbates the severity of viral myocarditis, likely through increased viral load and increased cardiomyocyte cell death.
Involvement of imidazoline and opioid receptors in the enhancement of clonidine-induced analgesia by sulfisoxazole
Authors: Boxwalla Mustufa , Matwyshyn George , Puppala Bhagya L. , Andurkar Shridhar V. , Gulati Anil 
Published: June 2010

Clonidine, an α2-adrenergic agonist, has been demonstrated to produce significant analgesia and potentiate morphine analgesia. Endothelin (ETA) receptor antagonists have also been found to potentiate the antinociceptive response to morphine. Clonidine and ET have been reported to have cardiovascular interactions involving the sympathetic nervous system, but it is not known whether ETAreceptor antagonist affects clonidine analgesia. This study examined the influence of sulfisoxazole (ETAreceptor antagonist) on clonidine analgesia. Male Swiss Webster mice were used to determine antinociceptive response of drugs by measuring tail-flick latency. The effect of clonidine (0.3, 1.0, and 3.0 mg/kg, i.p.) alone or in combination with sulfisoxazole (25, 75, and 225 mg/kg, p.o.) on analgesia and body temperature was determined. Clonidine produced a dose-dependent analgesia and hypothermia. Sulfisoxazole (25, 75, and 225 mg/kg), when administered with clonidine (0.3 mg/kg), significantly potentiated (31% increase in area under the curve (AUC)) the analgesic effect of clonidine. Yohimbine (α2-adrenergic receptor antagonist) did not affect analgesic effect of clonidine plus sulfisoxazole. Idazoxan (I1-imidazoline and α2-adrenergic receptor antagonist) reduced (47% decrease in AUC) the analgesic effect of clonidine plus sulfisoxazole. Treatment with naloxone reduced (46% decrease in AUC) the analgesic effect of clonidine plus sulfisoxazole. The effect of another ETAreceptor antagonist, BMS-182874 (2, 10, and 50 µg, i.c.v.) was studied, and it was found that the dose of 10 µg significantly potentiated (26% increase in AUC) the analgesic effect of clonidine. These results indicate that sulfisoxazole, an ETAreceptor antagonist, potentiates the analgesic effect of clonidine, which could be mediated through I1-imidazoline receptors and opioid receptors.
The role of the DDAH–ADMA pathway in the protective effect of resveratrol analog BTM-0512 on gastric mucosal injury
Authors: Li Li , Luo Xiu-Ju , Liu Ying-Zi , Zhang Yi-Shuai , Yuan Qiong , Tan Na , Xiang Da-Xiong , Peng Jun 
Published: June 2010

A recent study showed that resveratrol, a polyphenol found in many plant species, exerts dual effects on gastric mucosal injury. By using the model of ethanol-induced gastric mucosal injury in the present study, we explored the effect of trans-3,5,4′-trimethoxystilbene (BTM-0512), a novel analog of resveratrol, on gastric mucosal injury and the possible underlying mechanisms. Gastric mucosal injury in the rat was induced by oral administration of acidified ethanol. The gastric tissues were collected for determination of the gastric ulcer index, asymmetric dimethylarginine (ADMA) and nitric oxide (NO) contents, the activity of dimethylarginine dimethylaminohydrolase (DDAH) and superoxide anion (O2–) or hydroxyl radical (OH·) formation. The results showed that acute administration of ethanol significantly increased the gastric ulcer index concomitantly with the decrease in DDAH activity and NO content as well as the increase in ADMA content, effects that were reversed by pretreatment with BTM-0512 (100 mg/kg) or l-arginine (300 mg/kg). Administration of BTM-0512 did not show a significant effect on O2–or OH· formation. The results suggest that BTM-0512 could protect the gastric mucosa against ethanol-induced injury, which is mainly related to an increase in DDAH activity and subsequent decrease in ADMA content.
Survival and nesting success of the Pacific Eider (Somateria mollissima v-nigrum) near Bathurst Inlet, Nunavut
Authors: Hoover A. K. , Dickson D. L. , Dufour K. W. 
Published: June 2010

We used resighting data from 242 individually marked females to estimate apparent survival of Pacific Eiders ( Somateria mollissima v-nigrum Bonaparte, 1855) at a nesting colony in central arctic Canada from 2001 to 2007. In addition, we used data from nest searches conducted on islands at a freshwater lake and an adjacent marine environment to estimate annual breeding success. Annual survival rate estimates ranged from 0.84 ± 0.04 (mean ± SE) to 0.86 ± 0.05. Mayfield estimates of nest success ranged from 48.8% to 68.1% at the freshwater colony, and from 13.9% to 43.5% at the marine nesting colonies. The overwhelming cause of nest failure at both nesting areas was predation by grizzly bear ( Ursus arctos horribilis Ord, 1815), arctic fox ( Vulpes lagopus (L., 1758)), and wolverine ( Gulo gulo (L., 1758)). The majority of nests were initiated prior to ocean ice breakup in mid-July, thus mammalian predators had access to the islands well into incubation. Our results suggest that during the period from 2001 to 2007, the population of Pacific Eiders was likely not in decline. Therefore, the marked decline observed for eiders migrating past Point Barrow, Alaska, from 1976 to 1996 was more likely attributable to a stochastic event, such as unfavourable ice conditions, than to a chronic factor.
Fine-scale population structure and sex-biased dispersal in bobcats (Lynx rufus) from southern Illinois
Authors: Croteau Emily K. , Heist Edward J. , Nielsen Clayton K. 
Published: June 2010

In mammal populations, the spatial and genetic structure can be affected by dispersal, philopatry, and relatedness. Bobcats ( Lynx rufus (Schreber, 1777)) are thought to exhibit typical mammalian dispersal behaviour where males disperse and females are philopatric, potentially leading to higher relatedness among females compared with males. We used 10 microsatellite loci to examine population structure and sex-biased dispersal in 146 bobcats sampled in southern Illinois during 1993–2001 using population genetic descriptive statistics, a Bayesian clustering algorithm, relatedness (rxy), and autocorrelation analyses. A randomization test demonstrated that female dyads had significantly higher rxy values with respect to randomly selected dyads (rxy = 0.093 ± 0.222, P = 0.012) and spatial autocorrelation analyses determined that females in close proximity (<5 km) had a high probability of being related (P = 0.001). Conversely, rxy values for males were not different from the null distribution (rxy = 0.019 ± 0.122, P = 0.3158) and no significant relationships were found with spatial autocorrelation analysis. Additionally, it was demonstrated that bobcats in southern Illinois approximated a panmictic population with no obvious barriers to gene flow. The pattern of relatedness observed in this study confirmed that females were philopatric and males dispersed, corroborating existing observational data for this species.
Marine nutrient transport: anadromous fish migration linked to the freshwater amphipod Gammarus fasciatus
Authors: Hanson Natalie , Fogel Marilyn , Fong Daniel W. , MacAvoy Stephen E. 
Published: June 2010

Migrating anadromous fish may transfer marine-derived nutrients to oligotrophic tidal fresh water. River herrings (genus Alosa Linck, 1790) are the dominant anadromous genus in Virginia, USA. This study investigates whether marine nutrients derived from spawning Alosa spp. were incorporated into benthic invertebrates by using the stable isotopes of carbon and nitrogen. Spawning Alosa spp. had higher δ13C and δ15N values (–18.5‰ and 13.9‰, respectively) than resident freshwater omnivorous fishes (–25.7‰ and 11.8‰, respectively). In a tidal stream supporting abundant spawning Alosa spp., 13C and 15N enrichment was observed in stream amphipods (Gammarus fasciatus Say, 1818) coincident with the spawning migration of Alosa spp. The δ13C value for G. fasciatus increased from –28.5‰ to –26.0‰ from early to late April then fell to –28.1‰ in early June. A similar trend was observed in mayflies (Heptageniidae). Particulate organic matter and sediments from both streams remained depleted in 13C (between –29‰ and –28‰) and 15N (between 0.5‰ and 3.0‰) during the spawning run of Alosa spp. It is estimated that between 5% and 35% of amphipod biomass may be derived from marine carbon brought to tidal fresh water by spawning Alosa spp.
A NOTE ON COMPLETELY PRIME IDEALS OF ORE EXTENSIONS
Authors: BHAT V. K. 
Published: June 2010

The study of prime ideals has been an area of active research. In recent past a considerable work has been done in this direction. Associated prime ideals and minimal prime ideals of certain types of Ore extensions have been characterized.In this paper a relation between completely prime ideals of a ring R and those of R[x; σ, δ] has been given; σ is an automorphisms of R and δ is a σ-derivation of R. It has been proved that if P is a completely prime ideal of R such that σ(P) = P and δ(P) ⊆ P, then P[x; σ, δ] is a completely prime ideal of R[x; σ, δ]. It has also been proved that this type of relation does not hold for strongly prime ideals.