bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transmission patterns of multiple strains producing New Delhi metallo-β-lactamase variants among animals and the environment in live poultry markets
Authors: Yin Yi , Peng Kai , Li Yan , Zhang Wenhui , Gao Yanyun , Sun Xinran , Chen Sheng , Wang Zhiqiang , Li Ruichao 
Published: May 2024

AbstractThe widespread transmission of blaNDM among livestock and the live poultry industry attracts considerable public attention. However, studies have not yet addressed its impact on public health in live poultry markets (LPMs). Herein, we investigated the prevalence and genomic epidemiology of blaNDM-positive bacteria in various niches, and explored the transmission patterns of blaNDM within LPMs. Samples were collected between 2019 and 2022 from two LPMs in China. blaNDM was most prevalent in wastewater (35/66, 53.03%). All vegetable samples were negative for blaNDM. blaNDM was mainly distributed among Escherichia coli (266/336, 79.17%), Klebsiella pneumoniae (62/336, 18.45%), and Acinetobacter baumannii (3/336, 0.89%). Some novel hosts, including Pseudomonas monteilii and Pseudomonas otitis, were also identified. Diverse variants blaNDM-1, blaNDM-5, blaNDM-9, blaNDM-13, and blaNDM-27 were identified. The blaNDM-positive E. coli ST2659 was dominant. blaNDM was found to coexist with mcr-1 (4/51, 7.84%). Horizontal gene transfer plays a vital role in blaNDM transmission within the LPMs. Some blaNDM-harboring clones transfer among animals and the environment through the food chain and close contact. More efforts are needed to curb the transmission trend of blaNDM among humans, animals, and the environment within LPMs.
Determining cut-off values and predictors for the Snaith–Hamilton Pleasure Scale: comparison between clinical and school settings
Authors: Ho Yen-Chung , Gau Susan Shur-Fen , Wu Ying-Sian , Chen Chun-Hsin , Wang Jiunn-Kae , Lee Hsin-Chien , Chung Kuo-Hsuan , Chiu Yi-Hang , Goh Kah Kheng , Lu Mong-Liang , Lin Yu-Chun , Chang Pi-Chen , Chang Hsiu-Ju 
Published: May 2024

BackgroundFew previous studies have established Snaith–Hamilton Pleasure Scale (SHAPS) cut-off values using receiver operating characteristic curve analysis and applied these values to compare predictors of anhedonia between clinical and nonclinical groups.AimsTo determine the optimal cut-off values for the SHAPS and use them to identify predictors of anhedonia in clinical and nonclinical groups in Taiwan.MethodThis cross-sectional and correlational study used convenience sampling to recruit 160 patients from three hospitals and 412 students from two universities in northern Taiwan. Data analysis included receiver operating characteristic curve, univariate and multivariate analyses.ResultsThe optimal SHAPS cut-off values were 29.5 and 23.5 for the clinical and nonclinical groups, respectively. Moreover, two-stage analysis revealed that participants in the clinical group who perceived themselves as nondepressed, and participants in the nonclinical group who did not skip classes and whose fathers exhibited higher levels of care and protection were less likely to attain the cut-off values. Conversely, participants in the nonclinical group who reported lower academic satisfaction and were unwilling to seek help from family or friends were more likely to attain the cut-off values.ConclusionsOur findings highlight the importance of optimal cut-off values in screening for depression risk within clinical and nonclinical groups. Accordingly, the development of comprehensive, individualised programmes to monitor variation trends in SHAPS scores and relevant predictors of anhedonia across different target populations is crucial.
Radiation Oncology Training in the Philippines: Bridging Gaps for Improved Cancer Care in Low- and Middle-Income Countries
Authors: Jacomina Luisa E. , Agas Ryan Anthony F. , Benedicto Maria Teresa Julieta U. , Vega Gaudencio P. , Paulino Arnold C. , Mejia Michael Benedict A. 
Published: May 2024

PURPOSE Radiation oncology in the Philippines, a large lower- and middle-income country in Southeast Asia, is facing a critical shortage in manpower, with only 113 radiation oncologists (ROs) over 55 radiotherapy (RT) centers serving 100 million population. Paramount to workforce expansion is ensuring that training programs can produce adequately trained specialists. In this study, we describe the current state of radiation oncology training programs in the Philippines. METHODS This is a cross-sectional observational analysis of the nine radiation oncology residency training programs in the Philippines. Data were collected from a survey of the program directors, the Philippine Radiation Oncology Society database, and a PubMed literature search. RESULTS Eight of the nine programs are in the National Capital Region. Since program standardization in 2005, there have been 82 four-year residency graduates, with up to 18 new graduates annually. Faculty-to-trainee ratio ranges from 0.5 to 2.67. In terms of technology, all programs have intensity-modulated RT and high-dose-rate brachytherapy, but only six are equipped with computed tomography–based image guidance and stereotactic capabilities. Clinical education schemes vary per institution regarding curriculum implementation, resident activities, and methods of evaluation. Required resident case logs are not met for lung, GI, genitourinary, bone and soft tissue, and hematologic malignancies. In total, there are only 22 resident-led publications from 10 unique individuals in two training programs. CONCLUSION Program expansions are warranted to meet the projected demand for ROs in the Philippines, but training programs must first improve key aspects of staffing, technology, clinical education, and research. Addressing training challenges related to resource limitations necessitates local and international collaborations with higher-capacity centers to bridge gaps for continued quality improvement with the aim of ultimately delivering better overall cancer care.
First-Line Nivolumab and Relatlimab Plus Chemotherapy for Gastric or Gastroesophageal Junction Adenocarcinoma: The Phase II RELATIVITY-060 Study
Authors: Hegewisch-Becker Susanna , Mendez Guillermo , Chao Joseph , Nemecek Radim , Feeney Kynan , Van Cutsem Eric , Al-Batran Salah-Eddin , Mansoor Wasat , Maisey Nicholas , Pazo Cid Roberto , Burge Matthew , Perez-Callejo David , Hipkin R. William , Mukherjee Sourav , Lei Ming , Tang Hao , Suryawanshi Satyendra , Kelly Ronan J. , Tebbutt Niall C. 
Published: May 2024

PURPOSE Open-label phase II study (RELATIVITY-060) to investigate the efficacy and safety of first-line nivolumab, a PD-1–blocking antibody, plus relatlimab, a lymphocyte-activation gene 3 (LAG-3)–blocking antibody, plus chemotherapy in patients with previously untreated advanced gastric cancer (GC) or gastroesophageal junction cancer (GEJC). METHODS Patients with unresectable, locally advanced or metastatic GC/GEJC were randomly assigned 1:1 to nivolumab + relatlimab (fixed-dose combination) + chemotherapy or nivolumab + chemotherapy. The primary end point was objective response rate (ORR; per RECIST v1.1 by blinded independent central review [BICR]) in patients whose tumors had LAG-3 expression ≥1%. RESULTS Of 274 patients, 138 were randomly assigned to nivolumab + relatlimab + chemotherapy and 136 to nivolumab + chemotherapy. Median follow-up was 11.9 months. In patients with LAG-3 expression ≥1%, BICR-assessed ORR (95% CI) was 48% (38 to 59) in the nivolumab + relatlimab + chemotherapy arm and 61% (51 to 71) in the nivolumab + chemotherapy arm; median progression-free survival (95% CI) by BICR was 7.0 months (5.8 to 8.4) versus 8.3 months (6.9 to 12.1; hazard ratio [HR], 1.41 [95% CI, 0.97 to 2.05]), and median overall survival (95% CI) was 13.5 months (11.9 to 19.1) versus 16.0 months (10.9 to not estimable; HR, 1.04 [95% CI, 0.70 to 1.54]), respectively. Grade 3 or 4 treatment-related adverse events (TRAEs) occurred in 69% and 61% of all treated patients, and 42% and 36% of patients discontinued because of any-grade TRAEs in the nivolumab + relatlimab + chemotherapy and nivolumab + chemotherapy arms, respectively. CONCLUSION RELATIVITY-060 did not meet its primary end point of improved ORR in patients with LAG-3 expression ≥1% when relatlimab was added to nivolumab + chemotherapy compared with nivolumab + chemotherapy. Further studies are needed to address whether adding anti–LAG-3 to anti–PD-1 plus chemotherapy can benefit specific GC/GEJC patient subgroups.
Genomic Profiling of Rare Undifferentiated Sarcomatoid Subtypes of Pancreatic Carcinomas: In Search of Therapeutic Targets
Authors: Faber Erik B. , Krause Harris B. , Amin Khalid , Walker Philip , Hosein Peter J. , Shields Anthony F. , Lenz Heinz-Josef , Prakash Ajay , Goel Sanjay , Oberley Matthew , Malleo Giuseppe , Luchini Claudio , Hwang Justin , Florou Vaia , Garrido‐Laguna Ignacio , Lou Emil 
Published: May 2024

PURPOSE The highly aggressive undifferentiated sarcomatoid carcinoma (USC) subtype of pancreatic ductal adenocarcinoma (PDAC) remains poorly characterized because of its rarity. Previous case reports suggest that immune checkpoint inhibitors could be a promising treatment strategy, but the prevalence of established predictive biomarkers of response is largely unknown. The objective of this study was to leverage comprehensive genomic profiling of USC PDAC tumors to determine the prevalence of biomarkers associated with potential response to targeted therapies. METHODS USC tumors (n = 20) underwent central pathology review by a board-certified gastrointestinal pathologist to confirm the diagnosis. These samples were compared with non-USC PDAC tumors (N = 5,562). Retrospective analysis of DNA and RNA next-generation sequencing data was performed. RESULTS USC PDACs were more frequently PD-L1+ by immunohistochemistry than non-USC PDAC (63% v 16%, respectively, P < .001). Furthermore, USC PDAC had an increase in neutrophils (8.99% v 5.55%, P = .005) and dendritic cells (1.08% v 0.00%, q = 0.022) and an increased expression of PDCD1LG2 (4.6% v 1.3%, q = 0.001), PDCD1 (2.0% v 0.8%, q = 0.060), and HAVCR2 (45.9% v 21.7%, q = 0.107) than non-USC PDAC. Similar to non-USC PDAC, KRAS was the most commonly mutated gene (86% v 90%, respectively, P = 1). CONCLUSION To our knowledge, this work represents the largest molecular analysis of USC tumors to date and showed an increased expression of immune checkpoint genes in USC tumors. These findings provide evidence for further investigation into immune checkpoint inhibitors in USC tumors.
Behavior and morphology combine to influence energy dissipation in mantis shrimp (Stomatopoda)
Authors: Green P. A. 
Published: May 2024

ABSTRACT
Animals deliver and withstand physical impacts in diverse behavioral contexts, from competing rams clashing their antlers together to archerfish impacting prey with jets of water. Though the ability of animals to withstand impact has generally been studied by focusing on morphology, behaviors may also influence impact resistance. Mantis shrimp exchange high-force strikes on each other's coiled, armored telsons (tailplates) during contests over territory. Prior work has shown that telson morphology has high impact resistance. I hypothesized that the behavior of coiling the telson also contributes to impact energy dissipation. By measuring impact dynamics from high-speed videos of strikes exchanged during contests between freely moving animals, I found that approximately 20% more impact energy was dissipated by the telson as compared with findings from a prior study that focused solely on morphology. This increase is likely due to behavior: because the telson is lifted off the substrate, the entire body flexes after contact, dissipating more energy than exoskeletal morphology does on its own. While variation in the degree of telson coil did not affect energy dissipation, proportionally more energy was dissipated from higher velocity strikes and from strikes from more massive appendages. Overall, these findings show that analysis of both behavior and morphology is crucial to understanding impact resistance, and suggest future research on the evolution of structure and function under the selective pressure of biological impacts.
Stable polyethylene inlay fixation and low polyethylene wear rate in fixed-bearing total knee arthroplasty at five to six years’ follow-up
Authors: Jürgens-Lahnstein Jonathan H. , Petersen Emil T. , Rytter Søren , Madsen Frank , Søballe Kjeld , Stilling Maiken 
Published: May 2024

AimsMicromotion of the polyethylene (PE) inlay may contribute to backside PE wear in addition to articulate wear of total knee arthroplasty (TKA). Using radiostereometric analysis (RSA) with tantalum beads in the PE inlay, we evaluated PE micromotion and its relationship to PE wear.MethodsA total of 23 patients with a mean age of 83 years (77 to 91), were available from a RSA study on cemented TKA with Maxim tibial components (Zimmer Biomet). PE inlay migration, PE wear, tibial component migration, and the anatomical knee axis were evaluated on weightbearing stereoradiographs. PE inlay wear was measured as the deepest penetration of the femoral component into the PE inlay.ResultsAt mean six years’ follow-up, the PE wear rate was 0.08 mm/year (95% confidence interval 0.06 to 0.09 mm/year). PE inlay external rotation was below the precision limit and did not influence PE wear. Varus knee alignment did not influence PE wear (p = 0.874), but increased tibial component total translation (p = 0.041).ConclusionThe PE inlay was well fixed and there was no relationship between PE stability and PE wear. The PE wear rate was low and similar in the medial and lateral compartments. Varus knee alignment did not influence PE wear.Cite this article: Bone Joint Res 2024;13(5):226–236.
Machine Vision for Knot Detection and Location in Chinese Fir Lumber
Authors: Ji Min , Zhang Wei , Wang Guo-fu , Diao Xing-liang , Miao Hu , Gao Rui 
Published: May 2024

Abstract
In order to be utilized in the design of a wood building, the lumber must pass grade. Machine-vision inspection grading offers higher efficiency and accuracy than traditional manual visual grading. In this paper, a fast and accurate method for identifying defects in large-size structural lumber based on machine vision of Fujian Chinese fir (Cunninghamia lanceolata (Lamb.) Hook) constructional lumber (FCF CL) is proposed. Specifically, the grey matrix of the captured images on the surface of the sawn timber is initially scanned and the pixel weights on the edges of the image greyness variables are calculated. A matrix-valued torus was formed by fitting the knot edge profile and analyzing changes in the gradient values at the knot's edge, as well as calculating the directional derivative's rate of change. The knot three-dimensional mapping curves were projected onto the plane to form horizontal rise contours. Observe from the contour map of the whole large-size sawn timber, and extract the positional information of the knot where there is a trough (groove).
The test results show that the rRMSE (Relative Root Mean Square Error) measured at the x axis position of knots is within 0.49 percent; the rRMSE measured at the y axis is 0.35 percent, which has high detection accuracy and meets the production requirements. We also investigated the effect of knots in different positions on the modulus of elasticity and the bending strength of FCF CL, with a view to establishing a link between machine-vision knot detection and mechanical properties of sawn timber in our next work.
Comparing Wood Chip Quality from Different Sources across the Southeastern United States
Authors: Satterlee Dean L. , Hiesl Patrick , Smidt Mathew , Hagan Donald , Watson Edd , Gregory Leah , Rodrigues Brunella 
Published: May 2024

Abstract
Global use of renewable energy has risen over the past few decades because of international energy policy changes, new legislation, and an effort to create a more sustainable energy source for a rapidly growing global population. One of these renewable energy sources is biofuels, specifically in the form of wood pellets created from wood chips. Wood pellet manufacturers in the southeastern United States must adhere to rigid quality-control standards of the European markets where their pellets are shipped and consumed. Thus, there is a need to improve our understanding of the factors that influence the quality of the source materials. Higher heating value (HHV), moisture content (MC), ash content, elemental composition, and size stratification are all important quality factors to consider when analyzing wood chips. Variations in these quality factors can cause longer drying times, blockages in feed systems, excess waste, and fluctuations in energy output. The objective of this study was to quantify these quality factors across multiple sources of wood chips. Softwood and hardwood in-woods chip samples as well as softwood mill residual chips were collected from thinnings and clear-cuts across the southeastern United States. Softwoods had a greater HHV and MC than hardwood chips, with 18,949 kJ/kg and 18,242 kJ/kg, respectively. Softwood thinnings had the highest HHV and lowest ash content. However, only 4 of the 60 samples analyzed were from softwood thinnings. This study provides an overview of the variation in wood chip quality across the southeastern United States.
A Machine Learning Approach to Predict Properties of Wood Products during Milling
Authors: Derbas Mehieddine , Jaquemod André , Frömel-Frybort Stephan , Güzel Kamil , Moehring Hans-Christian , Riegler Martin 
Published: May 2024

Abstract
The wood industry seeks innovative methods to improve process monitoring and adaptive control by modeling workpiece characteristics. This study proposes a sensor fusion approach that integrates data from airborne sound, cutting forces, power consumption, and acoustic emissions while milling diverse wood-based products. The objective of this research is to accurately predict workpiece attributes, such as the density of the wood products to achieve strength grading and the roughness of the machined surfaces to identify tool wear or unsuitable process parameters. To accomplish this objective, machine learning regression was employed by training a model on the predictors chosen through supervised univariate feature ranking. Individual linear regression models per workpiece type depended heavily on the material, where the validation R2 values ranged from 0.1 to 0.99, due to presplitting in the case of samples machined across the fiber and porosity in the case of particleboard samples. A validation R2 of 0.99 could be achieved for the collective modeling of density based on all the collected samples, with samples machined against the fiber being excluded. Surface roughness could be predicted with a validation R2 of 0.91 by excluding samples machined across the fiber and particleboards.
Polymeric microlens array formed on a discontinuous wetting surface using a self-assembly technique
Authors: Xu Miao , Bian Zhenyao , Chen Qilong , Wang Haoran , Chen Cuifen , Lu Hongbo 
Published: May 2024

In this paper, we demonstrate a facile way to prepare polymeric microlens arrays (MLAs) based on a discontinuous wetting surface using a self-assembly technique. A patterned hydrophobic-octadecyltrichlorosilane (OTS) surface was prepared by UV/O3 irradiation through a shadow mask. The area exposed to UV/O3 irradiation turned highly hydrophilic, whereas the area protected by the mask remained highly hydrophobic, generating the patterned OTS surface. The surface energy of the OTS/glass surface changed from 23 to 72.8 mN/m after 17 min of UV/O3 treatment. The scribing of the optical glue-NOA 81 onto the microhole array enabled one to obtain the MLAs due to the generation of the NOA 81 droplet array via the surface tension. After UV light curing, the cured NOA 81 droplet array with uniform dimensions within a large area exhibited excellent MLA characteristics. Moreover, the method developed in this study is simple in operation, low-cost, and requires neither a clean room nor expensive equipment.
Analysis of continuous laser-irradiation resistance of liquid-crystal optical switch based on sapphire-substrate GaN
Authors: Han Zhilan , Fan Wei , Song Yantao , Huang Dajie , Cheng He , Pan Haoyuan , Lin Chen 
Published: May 2024

Developing high-power laser technology and its applications necessitates improvements in the laser-irradiation resistance of liquid-crystal modulation devices. In this study, the thermal characteristics of substrate and electrode materials, including sapphire-substrate indium tin oxide (ITO) electrodes, K9 glass-substrate ITO electrodes, sapphire-substrate gallium nitride (GaN) electrodes, and liquid-crystal optical switches, are investigated using simulation and experimental methods. Results show that the sapphire-substrate GaN electrode demonstrates the best heat dissipation and that the maximum temperature at the center of the spot under 75 W laser irradiation is 319 K, 52 K lower than that of an equally thick sapphire-substrate ITO electrode and 225 K lower than that of an equally thick K9 glass-substrate ITO electrode (steady state and test time >2min). Additionally, the experimental results show that the liquid-crystal optical switch, comprising a sapphire substrate and GaN electrode, can endure continuous laser irradiation up to 18 W with a switching ratio of approximately 20:1. The optical switch with GaN electrodes on a sapphire substrate can endure a power density of 156W/cm2, much higher than that (21W/cm2, steady state and test time >2min) tolerable by the liquid-crystal optical switch with ITO transparent electrodes and K9 glass substrates.
Clinical usability of 3D gradient-echo-based ultrashort echo time imaging: Is it enough to facilitate diagnostic decision in real-world practice?
Authors: Bak So Hyeon , Park Jinil , Lee Seokwon , Kim Jong Hee , Lee Ho Yun , Park Jang-Yeon 
Published: May 2024

Background
With recent advances in magnetic resonance imaging (MRI) technology, the practical role of lung MRI is expanding despite the inherent challenges of the thorax. The purpose of our study was to evaluate the current status of the concurrent dephasing and excitation (CODE) ultrashort echo-time sequence and the T1-weighted volumetric interpolated breath-hold examination (VIBE) sequence in the evaluation of thoracic disease by comparing it with the gold standard computed tomography (CT).

Methods
Twenty-four patients with lung cancer and mediastinal masses underwent both CT and MRI including T1-weighted VIBE and CODE. For CODE images, data were acquired in free breathing and end-expiratory images were reconstructed using retrospective respiratory gating. All images were evaluated through qualitative and quantitative approaches regarding various anatomical structures and lesions (nodule, mediastinal mass, emphysema, reticulation, honeycombing, bronchiectasis, pleural plaque and lymphadenopathy) inside the thorax in terms of diagnostic performance in making specific decisions.

Results
Depiction of the lung parenchyma, mediastinal and pleural lesion was not significant different among the three modalities (p > 0.05). Intra-tumoral and peritumoral features of lung nodules were not significant different in the CT, VIBE or CODE images (p > 0.05). However, VIBE and CODE had significantly lower image quality and poorer depiction of airway, great vessels, and emphysema compared to CT (p < 0.05). Image quality of central airways and depiction of bronchi were significantly better in CODE than in VIBE (p < 0.001 and p = 0.005). In contrast, the depiction of the vasculature was better for VIBE than CODE images (p = 0.003). The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were significant greater in VIBE than CODE except for SNRlung and SNRnodule (p < 0.05).

Conclusions
Our study showed the potential of CODE and VIBE sequences in the evaluation of localized thoracic abnormalities including solid pulmonary nodules.