bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of resilience‐related psychological interventions in patients with long‐term diseases: A meta‐analysis of randomised controlled trials
Authors: Janitra Fitria Endah , Chen Ruey , Lin Hui‐Chen , Sung Chien‐Mei , Chu Hsin , Lee Chiu‐Kuei , Niu Shu‐Fen , Liu Hsin‐I. , Chang Li‐Fang , Banda Kondwani Joseph , Chou Kuei‐Ru 
Published: April 2024

AbstractPatients with long‐term disease experience low resilience, emphasising the importance of psychological interventions to improve resilience. However, there is no comprehensive evidence on the efficacy of resilience‐related psychological interventions (RRPIs) in this population. Therefore, we performed a meta‐analysis to evaluate and extend knowledge from previous meta‐analyses on the efficacy of RRPIs on resilience, stress, anxiety, depression and quality of life among patients with long‐term disease. Cochrane Library, Embase, Ovid‐MEDLINE, PubMed, Scopus, Web of Science and CINAHL electronic databases were searched until 3 February 2023. The pooled effect size of the efficacy of RRPIs was calculated using the Hedges' g (g) with random‐effects model, while Cochrane Q‐statistics and I2 tests assessed heterogeneity in Comprehensive Meta‐Analysis 3.0 software. The Cochrane Risk of Bias 2.0 tool evaluated the quality of studies. Moderator analysis was used to explore sources of heterogeneity. Twenty randomised controlled trial studies were identified, representing a total of 1388 individuals with long‐term disease. RRPIs significantly enhance resilience (g = 0.79), alleviate stress (g = −0.78), decrease anxiety (g = −1.14), mitigate depression (g = −0.96) and improve quality of life (g = 0.48). Positive psychology, mindfulness, cognitive behavioural therapy, acceptance and commitment‐based intervention exhibited medium effects in strengthening resilience. Short‐term effects of RRPIs on enhancing resilience were observed at 3‐month follow‐up period (g = 0.50). The incorporation of RRPIs into the management of patients with long‐term disease shows a positive impact on their resilience, stress, anxiety, depression and quality of life. The results offer an evidence‐based foundation for nurses in promoting resilience among patients with long‐term disease.
The prevalence and factors of posttraumatic growth among nurses based on the PTGI: A systematic review and meta‐analysis
Authors: Zeng Li , Wang Jialin , Liu Guiling , Yuan Zhongqing , Yang Fengxue , Liu Dong , Li Lan , Peng Yihang 
Published: April 2024

AbstractBackgroundThe urgency and risk of clinical nursing may cause nurses to experience traumatic stress, but it may also lead to posttraumatic growth. However, no study has comprehensively analyzed the prevalence of posttraumatic growth among nurses using a unified outcome measure and a validated assessment tool.AimThis study aims to systematically assess the prevalence and factors of posttraumatic growth among nurses based on the Posttraumatic Growth Inventory (PTGI).MethodsTen databases, including The Cochrane Library, PubMed, Web of Science, CINAHL, Springerlink, Embase, Chinese Biomedical (CBM), China National Knowledge Infrastructure (CNKI), WanFang, and VIP databases, were searched as of December 31, 2022. The prevalence of posttraumatic growth was pooled using Stata 17.0 software. The PRISMA guideline was used to report the systematic review and meta‐analysis. PROSPERO registration number: CRD42022365620.ResultsA total of 30 studies were included in this systematic review and meta‐analysis, consisting of 14,022 nurses worldwide from four countries. In our study, the pooled mean score of posttraumatic growth among nurses was 66.34 (95% CI: 61.25–71.43). From 2015 to 2022, nurses’ posttraumatic growth levels gradually increased. In addition, Turkey nurses have the lowest posttraumatic growth levelnurses who experienced workplace violence have a lower posttraumatic growth level compared with other nurses; while nurses aged over 30 and male have higher posttraumatic growth levels.ConclusionsWhile several studies on the prevalence of posttraumatic growth among nurses have been published, the reported data are quite different. Our systematic review and meta‐analysis found that nurses’ posttraumatic growth level was “moderate,” and nurses’ posttraumatic growth may vary based on publication year, country, traumatic event, age, and gender.Implications for nursing and health policyOur findings may provide a theoretical basis for hospital administrators and policy makers to scientifically manage human resources, comprehensively evaluate nurses’ mental health, and promote nurses’ posttraumatic growth in different traumatic events, which is conducive to the formulation and implementation of relevant policy guidelines.
Self‐reported cultural competence among Czech and Slovakian nurses: A comparative correlation study
Authors: Červený Martin , Tóthová Valérie 
Published: April 2024

AbstractAimThis study aimed to compare the level of cultural competence among nurses working in clinical practice in Slovakia and the Czech Republic.BackgroundDemographic changes have greatly affected the health sector in Slovakia and the Czech Republic. By identifying the level of nurses’ cultural competence, many of the complications encountered in caring for patients from different cultures can be avoided. However, few studies have explored the cultural competence of nurses in clinical practice in these countries.MethodThis study was cross‐sectional, descriptive, and comparative. It followed the STROBE checklist and used the Cultural Competence Assessment Tool questionnaire to collect data. Descriptive and inferential statistical tests were utilized for data analysis, using SASD 1.5.8 and IBM SPSS Statistics version 28.0.0.ResultsThe sample comprised 424 nurses, with 202 from the Czech Republic and 222 from Slovakia, primarily female. Most nurses in both countries have not received cultural diversity training. Nevertheless, nurses in both countries indicate the necessity of conducting a cultural impact assessment of patients’ health. Cultural diversity training significantly increases the level of cultural competence in nurses.DiscussionLower cultural competence scores can negatively impact nursing care for patients from different cultures, leading to additional cultural challenges.Implications for nursing and health policyThe findings highlight the need for enhanced cultural competence among nurses. Nurses need to learn and utilize cultural information to help maximize healthcare for patients from different cultures. By providing nurses with cultural knowledge and skills, they will be able to deliver more effective and culturally competent care to patients from varied cultural backgrounds.
Effects of a structured educational program on nursing students' level of knowledge and awareness toward child neglect and abuse: A quasi‐experimental evaluation
Authors: Öztürk Ayfer 
Published: April 2024

AbstractBackgroundNurses have a key role in the recognition, reporting, and channelization of child abuse and neglect. Nurses should have sufficient knowledge about the presentation of child abuse and neglect. They also need to understand their role in reporting any instance where they detect cases of abuse and neglect.PurposeThe aim of this study is to determine the effect of a structured Child Neglect and Abuse Educational Program (CNaA‐EP) on the level of knowledge and awareness of nursing students about child neglect and abuse.MethodsThis study conducted with nursing students used a pretest−post‐test quasi‐experimental design. The third‐year nursing students were divided into two groups: experimental (n = 25) and control groups (n = 30). The intervention group received CNaA‐EP. In both groups, pretests were performed using the “Child Abuse and Neglect Awareness Scale,” and “Child Abuse and Neglect Knowledge Test” The posttest was conducted 1 week after the 14‐week CNaA‐EP course was completed. Numbers, percentages, chi‐square test, t‐test, Kolmogorov–Smirnov test, Fisher's exact test were conducted using SPSS 22.00 software.ResultsThe education group's scores of child abuse/neglect awareness (t = −2.768 p < 0.05) and child abuse/neglect knowledge (t = −12.416 p < 0.01) were significantly higher than those of the control group. After the education program, a significant difference was found between the education and control groups on the core measures.ConclusionA child neglect and abuse education program was an effective method of educating nursing students on knowledge and awareness of child abuse and neglect. For this reason, education programs should be planned and implemented to increase awareness about abuse and neglect problems that threaten children's health and development.
Validation of the RBP‐9801 oscillometric blood pressure monitor in the general population according to the association for the Advancement of Medical Instrumentation/European Society of Hypertension/ International Organization for Standardization Universal Standard
Authors: Yang Shijie , Zhou Zhanyang , Miao Huanhuan , Zhou Qiong , Zhai Mei , Zhang Yuqing 
Published: April 2024

AbstractThe aim of this study was to evaluate the accuracy of the single upper‐arm cuff oscillometric blood pressure (BP) monitor RBP‐9801 developed for office and home BP measurement in the general population according to the Association for the Advancement of Medical Instrumentation/European Society of Hypertension/International Organization for Standardization (AAMI/ESH/ISO) Universal Standard (ISO 81060–2:2018). Subjects were recruited to fulfil the age, gender, BP and cuff distribution criteria of the AAMI/ESH/ISO Universal Standard in general population using the same arm sequential BP measurement method. A total of 105 subjects were recruited and 85 were analyzed. For validation criterion 1, the mean ± SD of the differences between the test device and reference BP readings was 2.3 ± 6.4/3.1 ± 5.8 mmHg (systolic/diastolic). For criterion 2, the SD of the mean BP differences between the test device and reference BP per subject was 5.24/5.03 mmHg (systolic/diastolic). The conclusion is that the RBP‐9801 oscillometric device for office and home BP measurement fulfilled all the requirements of the AAMI/ESH/ISO Universal Standard (ISO 81060–2:2018) in the general population and can be recommended for clinic and self‐use at home.
Interplay of precision therapeutics and MD study: Calocybe indica's potentials against cervical cancer and its interaction with VEGF via octadecanoic acid
Authors: Datta Suhana , Verma Preeti , Dhara Bikram , Kundu Rita , Maitra Swastika , Mitra Arup Kumar , Khan Mohd Shahnawaz , Zughaibi Torki A. , Tabrez Shams , Kumer Ajoy 
Published: April 2024

AbstractThe evolving landscape of personalized medicine necessitates a shift from traditional therapeutic interventions towards precision‐driven approaches. Embracing this paradigm, our research probes the therapeutic efficacy of the aqueous crude extract (ACE) of Calocybe indica in cervical cancer treatment, merging botanical insights with advanced molecular research. We observed that ACE exerts significant influences on nuclear morphology and cell cycle modulation, further inducing early apoptosis and showcasing prebiotic attributes. Characterization of ACE have identified several phytochemicals including significant presence of octadeconoic acid. Simultaneously, utilizing advanced Molecular Dynamics (MD) simulations, we deciphered the intricate molecular interactions between Vascular Endothelial Growth Factor (VEGF) and Octadecanoic acid to establish C.indica's role as an anticancer agent. Our study delineates Octadecanoic acid's potential as a robust binding partner for VEGF, with comprehensive analyses from RMSD and RMSF profiles highlighting the stability and adaptability of the protein–ligand interactions. Further in‐depth thermodynamic explorations via MM‐GBSA calculations reveal the binding landscape of the VEGF–Octadecanoic acid complex. Emerging therapeutic innovations, encompassing proteolysis‐targeting chimeras (PROTACs) and avant‐garde nanocarriers, are discussed in the context of their synergy with compounds like Calocybe indica P&C. This convergence underscores the profound therapeutic potential awaiting clinical exploration. This study offers a holistic perspective on the promising therapeutic avenues facilitated by C. indica against cervical cancer, intricately woven with advanced molecular interactions and the prospective integration of precision therapeutics in modern oncology.
Weekly links among irritability and suicidal thoughts and behaviors in high‐risk youth
Authors: Kaurin Aleksandra , Wright Aidan G.C. , Porta Giovanna , Hamilton Edward , Poling Kimberly , Bero Kelsey , Brent David , Goldstein Tina R. 
Published: April 2024

BackgroundPrevious studies demonstrate a link between irritability and suicidal thoughts and behaviors (STBs) in youth samples. However, they have mostly assessed irritability in community samples and as a largely dispositional (i.e. trait‐like) construct. Thus, it remains unclear to what extent links between irritability and STBs reflect within‐person processes of elevated risk in clinically meaningful time periods.MethodsThe present study used clinical data from 689 adolescents aged 12–19 years attending a total of 6,128 visits at a specialty Intensive Outpatient Program for depressed and suicidal youth to examine patterns in weekly assessments of irritability and STBs throughout treatment, including associations among trends and fluctuations departing from these trends via multilevel structural equation modeling. Youth completed self‐report measures of irritability, depression, and STBs weekly as part of standard IOP clinical care.ResultsOverall, two‐thirds of variance in weekly irritable mood was accounted for by between‐person differences and the remaining portion by weekly fluctuations. After controlling for depression, during weeks when youth were more irritable they experienced increased STBs. Rates of change in irritability and STBs tended to track together at early stages of treatment, but these effects were generally accounted for by depression severity.ConclusionsOur results suggest that although changes in STBs are best accounted for by depression, irritability can be understood as a specific, proximal risk factor for youth STBs that exacerbates youth STBs in clinically informative timeframes above and beyond depression.
Tanshinone IIA suppresses ferroptosis to attenuate renal podocyte injury in diabetic nephropathy through the embryonic lethal abnormal visual‐like protein 1 and acyl‐coenzyme A synthetase long‐chain family member 4 signaling pathway
Authors: Zhu Shuai , Kang Zhiqiang , Zhang Fengjiao 
Published: April 2024

AbstractAims/IntroductionTanshinone IIA (TIIA) is one of the main components of the root of the red‐rooted Salvia miltiorrhiza Bunge. However, the molecular mechanisms underlying TIIA‐mediated protective effects in diabetic nephropathy (DN) are still unclear.Materials and MethodsHigh glucose (HG)‐induced mouse podocyte cell line (MPC5) cells were used as the in vitro model of DN and treated with TIIA. Cell viability, proliferation and apoptosis were detected using 3‐(4, 5‐dimethylthiazolyl‐2)‐2, 5‐diphenyltetrazolium bromide, 5‐ethynyl‐2′‐deoxyuridine and flow cytometry assays. The protein levels were assessed using western blot assay. The levels of inflammatory factors were deleted by enzyme‐linked immunoassay. Fe+ level, reactive oxygen species, malondialdehyde and glutathione products were detected using special assay kits. After ENCORI prediction, the interaction between embryonic lethal abnormal visual‐like protein 1 (ELAVL1) and acyl‐coenzyme A synthetase long‐chain family member 4 (ACSL4) was verified using co‐immunoprecipitation assay and dual‐luciferase reporter assays. ACSL4 messenger ribonucleic acid expression was measured using real‐time quantitative polymerase chain reaction.ResultsTIIA repressed HG‐induced MPC5 cell apoptosis, inflammatory response and ferroptosis. ACSL4 upregulation relieved the repression of TIIA on HG‐mediated MPC5 cell injury and ferroptosis. ELAVL1 is bound with ACSL4 to positively regulate the stability of ACSL4 messenger ribonucleic acid. TIIA hindered HG‐triggered MPC5 cell injury and ferroptosis by regulating the ELAVL1–ACSL4 pathway. TIIA blocked DN progression in in vivo research.ConclusionTIIA treatment restrained HG‐caused MPC5 cell injury and ferroptosis partly through targeting the ELAVL1–ACSL4 axis, providing a promising therapeutic target for DN treatment.
Implementation of virtual academic detailing in North America: A qualitative study
Authors: Nazari Jonathan L. , Kulbokas Victoria , Smart Mary H. , Hensle Tara R. , Lee Todd A. , Pickard A. Simon 
Published: April 2024

AbstractRationaleThe shift toward virtual academic detailing (AD) was accelerated by the COVID‐19 pandemic.Aims and ObjectivesWe aimed to examine the role of external, contextual, and intrinsic programme‐specific factors in virtual engagement of healthcare providers (HCPs) and delivery of AD.MethodsAD groups throughout North America were contacted to participate in semistructured interviews. An interview guide was constructed by adapting the Consolidated Framework for Implementation Research (CFIR). A point of emphasis included strategies AD groups employed for provider engagement while implementing virtual AD programmes. Independent coders conducted qualitative analysis using the framework method.ResultsFifteen AD groups from Canada (n = 3) and the United States (n = 12) participated. Technological issues and training detailers and HCPs were challenges during the transition to virtual AD visits. Restrictions on in‐person activities during the pandemic created difficulties engaging HCPs and fewer AD visits. Continuing education was one strategy to incentivize participation, but credits were often not claimed by HCPs. Groups with established networks and prior experience with virtual AD leveraged connections to mitigate disruptions and continue AD visits. Other facilitators included emphasizing contemporary topics, including opioid education beyond fundamental guidelines. Virtual AD had the additional benefit of expanding geographic reach and flexible scheduling with providers.ConclusionsAD groups across North America have shifted to virtual outreach and delivery strategies. This trend toward virtual AD may aid outreach to vulnerable rural communities, improving health equity. More research is needed on the effectiveness of virtual AD and its future implications.
The role of tumor‐associated macrophages in hepatocellular carcinoma—from bench to bedside: A review
Authors: Gryziak Maciej , Kraj Leszek , Stec Rafał 
Published: April 2024

AbstractHepatocellular carcinoma is one of the most common cancers worldwide. Despite progress in treatment, recurrence after radical treatment is common, and the prognosis remains poor for patients with advanced disease. Therefore, there is a need to identify prognostic and predictive factors for the response to therapy or more intensive surveillance or treatment. Because the tumor microenvironment plays a crucial role in the development of cancer and metastasis, it is a crucial need to understand processes that are involved in carcinogenesis. Within the microenvironment, several immune cells with different roles are present. One of the most important of these is tumor‐associated macrophages. These cells may exert either antitumor or protumor roles. Several studies have suggested that tumor‐associated macrophages can be used as prognostic markers. Furthermore, they may be involved in resistance to immunotherapy or systemic treatment. As they play an important role in cancer development, tumor‐associated macrophages are also a good target for therapy. In this review, we briefly summarize recent progress on knowledge regarding the basic molecular characteristics, impact on prognosis and potential clinical implications of tumor‐associated macrophages in hepatocellular carcinoma.
Enhancing oral function: A case report on mandibular overdenture utilization with custom‐made subperiosteal implant
Authors: Fathi Amirhossein , Nadian Farshad , Ghorbani Mahsa , Razavi Pouyan , Mosharraf Ramin , Ebadian Behnaz 
Published: April 2024

AbstractSubperiosteal implants, previously set aside because of complications, are now emerging again as effective treatments for severe mandibular atrophy, aided by recent improvements in digital dentistry. Traditional dentures in such cases often face challenges with support and retention, necessitating complex regenerative procedures. This paper presents a case report of a 54‐year‐old male patient with significant mandibular atrophy who received a custom‐made subperiosteal implant, showcasing promising results. The implant was precisely designed utilizing computed tomography (CT) scans, a 3D‐printed model, the selective laser melting (SLM) technique, and constructed with biocompatible Ti6Al4V material. This innovative approach offered a practical solution, resulting in high patient satisfaction and no complications over a year of use.
Development and initial validation of the parental response to adolescents' emotions scale: A mixed methods approach
Authors: Hu Jennifer , Zheng Qinliang , Zhou Ting , Huang Zheng 
Published: April 2024

AbstractAn exploratory mixed methods design was used to explore age‐appropriate characteristics of parental response to emotion (PRE) during adolescence in Chinese families and develop the parental response to adolescents' emotions scale (C‐PRAES). Qualitative interviews with 21 parent–adolescent dyads were employed to explore characteristics of PRE in adolescence and generate item pools. Structural validity, criterion validity, measurement invariance across informants (adolescents vs. parents, mothers vs. fathers) and consistency reliability were examined in the quantitative phase (Nadolescent = 702, Nparent = 476). New age‐appropriate strategies were generated from qualitative phase: Guidance in reappraisal, Allowing independent regulation, and Avoiding escalation of conflict. The formal version of the C‐PRAES comprised items in two dimensions (supportive/non‐supportive) and exhibited good validity, reliability, and measurement invariance.
Using GPT‐4 for LI‐RADS feature extraction and categorization with multilingual free‐text reports
Authors: Gu Kyowon , Lee Jeong Hyun , Shin Jaeseung , Hwang Jeong Ah , Min Ji Hye , Jeong Woo Kyoung , Lee Min Woo , Song Kyoung Doo , Bae Sung Hwan 
Published: April 2024

AbstractBackground and AimsThe Liver Imaging Reporting and Data System (LI‐RADS) offers a standardized approach for imaging hepatocellular carcinoma. However, the diverse styles and structures of radiology reports complicate automatic data extraction. Large language models hold the potential for structured data extraction from free‐text reports. Our objective was to evaluate the performance of Generative Pre‐trained Transformer (GPT)‐4 in extracting LI‐RADS features and categories from free‐text liver magnetic resonance imaging (MRI) reports.MethodsThree radiologists generated 160 fictitious free‐text liver MRI reports written in Korean and English, simulating real‐world practice. Of these, 20 were used for prompt engineering, and 140 formed the internal test cohort. Seventy‐two genuine reports, authored by 17 radiologists were collected and de‐identified for the external test cohort. LI‐RADS features were extracted using GPT‐4, with a Python script calculating categories. Accuracies in each test cohort were compared.ResultsOn the external test, the accuracy for the extraction of major LI‐RADS features, which encompass size, nonrim arterial phase hyperenhancement, nonperipheral ‘washout’, enhancing ‘capsule’ and threshold growth, ranged from .92 to .99. For the rest of the LI‐RADS features, the accuracy ranged from .86 to .97. For the LI‐RADS category, the model showed an accuracy of .85 (95% CI: .76, .93).ConclusionsGPT‐4 shows promise in extracting LI‐RADS features, yet further refinement of its prompting strategy and advancements in its neural network architecture are crucial for reliable use in processing complex real‐world MRI reports.