bluuebunny/crossref_metadata_2025_split huggingface dataset:
Limiting and detecting bacterial contamination of apheresis platelets: inlet‐line diversion and increased culture volume improve component safety
Authors: Eder Anne F. , Kennedy Jean M. , Dy Beth A. , Notari Edward P. , Skeate Robert , Bachowski Gary , Mair David C. , Webb Jonathan S. , Wagner Stephen J. , Dodd Roger Y. , Benjamin Richard J. ,   the American Red Cross Regional Blood Centers
Published: April 2009

BACKGROUND: Septic transfusion reactions to apheresis platelets (PLTs) continue to occur despite preventive measures. This study evaluated the effect of two operational changes designed to reduce bacterial risk: 1) introducing inlet‐line sample diversion on two‐arm procedures and 2) increasing the sample volume cultured from 4 to 8 mL from all donations.STUDY DESIGN AND METHODS: Aerobic culture results and septic transfusion reactions reported between December 1, 2006, and July 31, 2008 (Period 2), were compared to March 1, 2004, to May 31, 2006 (Period 1).RESULTS: During Period 2, a total of 781,936 apheresis PLT collections were cultured, of which 130 donations (1:6015) were confirmed positive and 9 (1:86,882) had negative culture results but were associated with 11 septic reactions. Confirmed‐positive cultures from two‐arm procedures decreased (27.2 to 14.7 per 105 collections; odds ratio [OR], 0.54; 95% confidence interval [CI], 0.41‐0.70) in Period 2, owing to a lower rate of skin flora contamination. Detection of contamination of one‐arm collections significantly increased by 54% in Period 2 (13.7 vs. 21.1 per 105 collections; OR, 1.54; 95% CI, 1.05‐2.27). Fewer septic transfusion reactions occurred in Period 2, but the difference did not reach significance (1.7 vs. 1.2 per 105 donations; OR, 0.68; 95% CI, 0.30‐1.53).CONCLUSION: Inlet‐line diversion decreased bacterial contamination during two‐arm collections by more than 46%. Concurrently, doubling the sample volume was associated with a 54% relative increase in culture sensitivity. These interventions act cooperatively to decrease bacterial risk.
Dombrock genotyping in a native Congolese cohort reveals two novel alleles
Authors: Chapel‐Fernandes Sylvie , Callebaut Isabelle , Halverson Gregory R. , Reid Marion E. , Bailly Pascal , Chiaroni Jacques 
Published: April 2009

BACKGROUND: Since variant alleles in the Dombrock (DO) blood group system are common in Africans, DNA typing of DO alleles in an uninvestigated Congolese Teke ethnic group was performed.STUDY DESIGN AND METHODS: DO exons were polymerase chain reaction amplified, using genomic DNA extracted from blood samples, and sequenced. Membrane expression in K562 cells transduced with DO‐cDNAs using lentiviral vectors was studied by flow cytometry. Amino acid changes were mapped on the protein structure, predicted by homology modeling.RESULTS: In 41 samples investigated, there were 56 DOB or DOB‐WL (68%), 15 DOA (18%), 6 HY (7%), and 3 JO (4%) alleles. The remaining two alleles were novel, that is, DOB‐SH‐Gln149Lys carrying a 445C>A transversion and DOB‐(WL)‐Ile175Asn showing a 524T>A transversion on a DOB or DOB‐WL background. Transduced K562 cells revealed that DOB‐SH‐Gln149Lys variant was expressed to the same extent as DOB‐SH but to a lesser extent than the DOB control. The DOB‐Ile175Asn variant shows equivalent expression to DOB but is not recognized by monoclonal antibodies MIMA‐53. As deduced from the protein model, these missense changes would lead to structure similar to the wild‐type one, with only modified surface features.CONCLUSION: Molecular screening of Teke individuals revealed a high frequency of HY and JO alleles and two novel alleles, one on the DOB (or DOB‐WL) and one on the DOB‐SH background. Expression studies highlighted the impact of changes on Do protein expression. These findings suggest that allelic diversity is greater than expected and that expression level of DO alleles should be taken into account in transfusion.
Peri‐Implant Endosseous Healing Properties of Dual Acid‐Etched Mini‐Implants with a Nanometer‐Sized Deposition of CaP: A Histological and Histomorphometric Human Study
Authors: Telleman Gerdien , Albrektsson Tomas , Hoffman Maria , Johansson Carina B. , Vissink Arjan , Meijer Henny J.A. , Raghoebar Gerry M. 
Published: April 2009

ABSTRACTPurpose: The aim of this histological and histomorphometric study was to compare the early peri‐implant endosseous healing properties of a dual acid‐etched (DAE) surface (Osseotite®, Implant Innovations Inc., Palm Beach Gardens, FL, USA) with a DAE surface modified with nanometer‐sized calcium phosphate (CaP) particles (NanoTite™, Implant Innovations Inc.) in grafted and mature maxillary bone.Materials and Methods: Fifteen patients received two mini‐implants, 1 with DAE surface (control) and 1 with a DAE + CaP surface (test), to fixate an iliac crest bone graft to the maxilla. A part of each mini‐implant was in contact with the grafted bone and a part extended into the native maxillary bone. After a healing period of 3 months, the specimens were harvested and analyzed.Results: Overall, a trend was seen for stronger bone response around the test mini‐implants in the native bone of the maxilla. However, only the old bone particles measured by percentages of bone‐to‐implant contact and bone area were statistically significant (p = .025 and p = .042, respectively).Conclusions: The NanoTite surface increases the peri‐implant endosseous healing properties in the native bone of the maxilla compared with the Osseotite surface, while this difference was not visible in the bone graft area. This might be a result of the lower remodeling process of the graft.
Loading Protocols for Mandibular Implant Overdentures: A Systematic Review with Meta‐Analysis
Authors: Alsabeeha Nabeel , Atieh Momen , Payne Alan G.T. 
Published: April 2009

ABSTRACTBackground: Mandibular overdentures are a successful treatment option for the edentulous patients with long‐term predictable outcomes, using conventional loading protocols. Currently, both early and immediate loading protocols for mandibular implant overdentures are prevalent in the literature.Purpose: A systematic review and meta‐analysis of the current published literature on comparative studies using conventional versus either early and/or immediate loading protocols for mandibular implant overdentures.Materials and Methods: The review was carried out in accordance with the QUOROM (Quality of Reporting of Meta‐Analyses) guidelines. The PICO (Population, Intervention, Comparisons, Outcomes) format was used in conjunction with predefined inclusion criteria. A literature search of PubMed (1969–October 2008), EMBASE (1998–October 2008), the Cochrane Database of Systematic Reviews, and the Cochrane Controlled Trial Register was conducted. In addition, hand searching through refereed dental journals was also performed for the years 2000 to 2008. The meta‐analysis was conducted by using the MIX software v.1.7 (Kitasato Clinical Research Center, Kanagawa, Japan).Results: A total of 191 studies were identified through the electronic search. After full‐text screening and cross‐matching with the predefined inclusion criteria, only 10 studies with a minimum follow‐up of 2 years were eligible for inclusion in this review. Of the 10 included studies, seven have compared the outcome of conventional versus early loading of implants supporting mandibular overdentures. The remaining three studies, on the other hand, compared the outcome of conventional versus immediate loading. The meta‐analysis revealed no significant difference in the outcome between conventional and either early (p = .72) or immediate (p = .08) loading of implants supporting mandibular implant overdentures.Conclusions: Short‐term outcomes of early or immediate loading protocols for mandibular implant overdentures achieved comparable success to conventional loading ones. No evidence was found of long‐term studies to support or refute either early or immediate loading protocols for mandibular implant overdentures.
One‐Year Outcome of Implants Strategically Placed in the Retrocanine Bone Triangle
Authors: Balleri Piero , Ferrari Marco , Veltri Mario 
Published: April 2009

ABSTRACTBackground: Implant treatment in the partially edentulous maxilla is often challenging because of minimum bone volumes in distal direction.Purpose: The aim of this study was to evaluate, after 1 year of loading, the outcome of three‐unit fixed partial dentures supported by two implants in the retrocanine triangle.Materials and Methods: Twenty patients with atrophic posterior maxillae participated in the study. A total of 40 implants were placed in residual bone anterior to the sinus wall and posterior to the canine. Implant angulations and lengths were chosen to match as much as possible boundaries of the available bone. After a 6‐month healing period, three‐unit, screw‐retained, fixed partial dentures were delivered. The patients were clinically and radiographically reexamined after 1 year of loading.Results: All the implants survived at the end of the follow‐up. No differences in bone level changes resulted between axial and tilted implants. No biological or mechanical complications were recorded.Conclusions: Within the limitations of this short‐term study on relatively few patients, a positive outcome was seen for three‐unit fixed partial dentures supported by two implants. Retrocanine placement of implants with carefully planned lengths and angulations might be an alternative to grafting procedures for restoration of atrophic posterior maxillae.
Effect of Systemic Tetracycline on the Degradation of Tetracycline‐Impregnated Bilayered Collagen Membranes: An Animal Study
Authors: Moses Ofer , Frenkel Tami , Tal Haim , Weinreb Miron , Bornstein Michael M. , Nemcovsky Carlos E. 
Published: April 2009

ABSTRACTBackground: Premature collagen membrane degradation may compromise the outcome of osseous regenerative procedures. Tetracyclines (TTCs) inhibit the catalytic activities of human metalloproteinases. Preprocedural immersion of collagen membranes in TTC and systemic administration of TTC may be possible alternatives to reduce the biodegradation of native collagen membranes.Aim: To evaluate the in vivo degradation of collagen membranes treated by combined TTC immersion and systemic administration.Materials and Methods: Seventy‐eight bilayered porcine collagen membrane disks were divided into three groups and were immersed in 0, 50, or 100 mg/mL TTC solution. Three disks, one of each of the three groups, were implanted on the calvaria of each of 26 Wistar rats. Thirteen (study group) were administered with systemic TTC (10 mg/kg), while the remaining 13 received saline injections (control group). Calvarial tissues were retrieved after 3 weeks, and histological sections were analyzed by image analysis software.Results: Percentage of remaining collagen area within nonimpregnated membranes was 52.26 ± 20.67% in the study group, and 32.74 ± 13.81% in the control group. Immersion of membranes in 100 mg/mL TTC increased the amount of residual collagen to 63.46 ± 18.19% and 42.82 ± 12.99% (study and control groups, respectively). Immersion in 50 mg/mL TTC yielded maximal residual collagen values: 80.75 ± 14.86% and 59.15 ± 8.01% (study and control groups, respectively). Differences between the TTC concentrations, and between the control and the study groups were statistically significant.Conclusions: Immersion of collagen membranes in TTC solution prior to their implantation and systemic administration of TTC significantly decreased the membranes' degradation.
Newborn Individual Development Care and Assessment Program (NIDCAP): A Systematic Review of the Literature
Authors: Wallin Lars , Eriksson Mats 
Published: April 2009

ABSTRACT Background: Important advancements have been made in the care of preterm infants. Health services have introduced various methods aimed at promoting attachment, breastfeeding, and neurological development. The Newborn Individualized Developmental Care and Assessment Program (NIDCAP), developed to stimulate preterm infants at levels adapted to the child's degree of neurological maturity, is increasingly being used. Objectives: The aim was to investigate the impact of NIDCAP on the psychomotor development, neurological status, medical/nursing care outcomes, and parental perceptions. A further aim was to evaluate the cost‐related effects of NIDCAP. Data Extraction and Analysis: A literature search up to September 2007 was performed. The reviewed papers were assessed for methodological quality and only statistically significant findings were extracted. Findings: The evidence compiled on the effects of NIDCAP is based on 12 articles from six randomized controlled trials that included approximately 250 children. Each of the studies was assessed as having medium quality. Most of the studies were small and many investigated a huge number of outcome variables, which decreased their scientific strength. On outcome variables in which a significant difference was found between the intervention (NIDCAP) and control groups, most studies showed better results for the NIDCAP group. This was particularly valid for cognitive and psychomotor development. Four studies also showed a reduced need for respiratory support for the NIDCAP group. No studies were identified that weighed the total cost of NIDCAP against its effects. Conclusions: Despite promising findings, primarily on cognitive and motor development, the scientific evidence on the effects of NIDCAP is limited. Shortcomings in design and methods in the reviewed studies hamper far‐reaching claims on the effectiveness of the method. Scientific grounds for assessing the effects of NIDCAP would be substantially enhanced by a sufficiently comprehensive study with extended follow‐up and a clear focus on a few important outcome variables.
Evoked Human Oesophageal Hyperalgesia: A Potential Tool for Analgesic Evaluation?
Authors: Olesen Anne Estrup , Staahl Camilla , Brock Christina , Arendt‐Nielsen Lars , Drewes Asbjørn Mohr 
Published: April 2009

Abstract:  Hypersensitivity is a common finding in visceral disorders. Therefore, in the development and testing of analgesics for the treatment of visceral pain, it is important to establish an experimental pain model of visceral hypersensitivity. Such a model will mimic the clinical situation to a higher degree than pain models where the receptors and peripheral afferents are briefly activated as with, for example, electrical, thermal, and mechanical stimulations. In this study, a model to evoke experimental hyperalgesia of the oesophagus with a combination of acid and capsaicin was introduced. The study was a randomised, double‐blind, cross‐over study. Fifteen healthy volunteers were included. Sensory assessments to mechanical, heat, and electrical stimulations were done in the distal oesophagus, before and after perfusion with a 200 ml solution of acid+capsaicin (180 ml HCL 0.1 M and 2 mg capsaicin in 20 ml solvent) or saline. Oesophageal pain assessment and referred pain areas were evaluated. There were reproducible pain assessments between repetitions within the same day and between days (all P > 0.05). Acid+capsaicin perfusion induced 56% reduction of the pain threshold to heat (P = 0.04), 19% reduction of the pain threshold to electrical stimuli (P < 0.001), 78% increase of the referred pain areas to mechanical stimulation (P < 0.001) and 52% increase of the referred pain areas to electrical stimulus (P = 0.045). All volunteers were sensitised to one or more modalities by acid+capsaicin. The model was able to evoke consistent hyperalgesia and may be useful in future pharmacological studies.
Parenting Stress in Mothers of Children With Autism Spectrum Disorders
Authors: Phetrasuwan Supapak , Shandor Miles Margaret 
Published: April 2009

PURPOSE.  The purpose of this paper is to describe the sources of parenting stress in mothers of children with Autism Spectrum Disorders (ASD) and examine the relationship between parenting stress and maternal psychological status (depression and well‐being).DESIGN AND METHODS.  A descriptive correlational design was used. Data were collected via mailed questionnaires.RESULTS.  Behavioral symptoms were the primary source of parenting stress for mothers. There was no relationship between child characteristics and parenting stress. Mothers reporting more parenting stress had more depressive symptoms and lower levels of well‐being.PRACTICE IMPLICATIONS.  Our findings have implications for interventions with mothers to help them manage their children's behavior and focus on stress reduction and well‐being.
Institutional foodservice benchmarking: survey of administrators' attitudes and practices in the USA
Authors: Bright Saunya N. , Kwon Junehee , Bednar Carolyn , Newcomer Julia 
Published: April 2009

AbstractBenchmarking is an ongoing process that gathers information to evaluate the best practices and improve performance. Despite possible changes and benefits, research reporting current foodservice benchmarking is limited. A nationwide survey of foodservice administrators was conducted to determine current practices and administrators' attitudes toward benchmarking. A questionnaire was developed, validated by experts and pilot‐tested. Randomly selected, 600 foodservice administrators from health‐care, school, correctional and university facilities received questionnaires, and 121 provided usable data (20%). Food cost percentage, labor cost percentage, and percent customer satisfaction with service were the three most used measures. Benchmarking was regarded as important in performing most respondents' jobs (61%), but fewer indicated their benchmarking knowledge as being above average (48%). For training, 41% indicated needs for training on ways to collaborate with benchmarking partners. The majority preferred training through professional association meetings (70%) and Internet‐based training (69%). Results indicate opportunities for benchmarking training preferably through meetings and Internet.
Longterm follow‐up of diode laser transscleral cyclophotocoagulation in the treatment of refractory glaucoma
Authors: Frezzotti Paolo , Mittica Vincenzo , Martone Gianluca , Motolese Ilaria , Lomurno Luca , Peruzzi Sabrina , Motolese Edoardo 
Published: April 2009

Abstract.Purpose:  This prospective study was conducted to evaluate the efficacy and safety of transscleral diode laser cyclophotocoagulation (TDLCP) in advanced refractory glaucoma.Methods:  A total of 124 eyes in 121 patients with advanced glaucoma refractory to medical treatment were treated consecutively with TDLCP. Success was defined as final intraocular pressure (IOP) of 5−21 mmHg in eyes with visual acuity (VA) of more than hand movements (HM) and relief of pain in eyes with VA of HM or less, including blind eyes.Results:  Mean patient age was 65.6 ± 17.1 years (range 14–91 years). Mean follow‐up was 17 ± 14.6 months (range 3–42 months). Mean pretreatment IOP was 29.9 ± 8.4 mmHg (range 17–58 mmHg) and IOP at last follow‐up was 20.8 ± 8 mmHg (range 6–45 mmHg) (p < 0.001). The number of laser applications (mean 9.2 ± 2.8, range 4–15) and maximal laser power (mean 2.01 ± 0.22 mW, range 1.3–3.0 mW) were not associated with lower postoperative IOP. Intraocular pressure of ≤ 21 mmHg was recorded in 63.0% of eyes at the last follow‐up visit. Overall, 28 (21.7%) eyes required at least one retreatment. No phthisis bulbi or persistent hypotonia developed.Conclusions:  TDLCP is an effective and safe method for the treatment of advanced refractory glaucoma, although repeated treatments are often necessary.
Organizational Self‐Censorship: Corporate Sponsorship, Nonprofit Funding, and the Educational Experience*
Authors: GRAY GARRY C. , BISHOP KENDZIA VICTORIA 
Published: April 2009

La dépendance croissante du secteur privé envers la commandite a eu des conséquences sur la gouvernance des organismes sans but lucratif (OSBL). La recherche traditionnelle sur le financement a pris un angle d'observation essentiellement positif, montrant que les OSBL peuvent trouver des occasions d'influencer les intérêts de leurs bailleurs de fonds de manière à ce qu'ils deviennent plus compatibles avec la mission de l'OSBL. Dans cet article, les auteurs s'inspirent de ce travail en fournissant un examen plus nuancé de l'intermédiaire dans l'OSBL. Plus précisément, les auteurs introduisent une forme négative d'intermédiaire connue sous le nom d'autocensure organisationnelle. En examinant l'autocensure, ils montrent que les OSBL devraient plutôt redéfinir leurs propres buts de manière à attirer les bailleurs de fonds du secteur privé.Increasing reliance on corporate sponsorship has impacted the governance of nonprofit organizations. Traditional research on funding has taken a predominately positive vantage point, expressing that nonprofit organizations may find opportunities to influence their funder's interests such that they become more compatible with the nonprofit organization's mission. In this article, we build upon this work by providing a more nuanced examination of agency in the nonprofit organization. Specifically, we introduce a negative form of agency known as organizational self‐censorship. By examining self‐censorship, we reveal that nonprofit organizations may instead redefine their own goals in order to appeal to private sector funders.
Rare association of Parvovirus B19 infection in Kikuchi's lymphadenitis in Korea
Authors: Shin Bongkyung , Choi Jung Woo , Kim Insun 
Published: April 2009

ABSTRACTBackground and aims:To determine the role of parvovirus B19 (PVB19) in Kikuchi's lymphadenitis of Korean patients.Methods:We detected PVB19 DNA by polymerase chain reaction, and confirmed by DNA sequencing, and immunohistochemical stain in 67 histologically confirmed cases.Results:Male to female ratio was 1:3 and the mean age was 24.6 years. The cases were classified into proliferative type (60.8%), necrotizing type (33.3%), and xanthomatous type (5.7%) and the duration of the disease was well correlated with progression from proliferative, necrotizing and xanthomatous types. PVB19 was detected in only one patient, who was a 33‐year old woman and did not show any specific clinicopathologic characteristics from other patients.Conclusions:Although parvovirus may not play an important role in Kikuchi's lymphadenitis in Korean patients, PVB19 may be still considered one of the agents, relating with Kikuchi's lymphadenitis in Korea. In contrast to the previous studies, we concluded that the association of PVB19 in Kikuchi's lymphadenitis may be an incidental finding rather than a constant features of this disease.