bluuebunny/crossref_metadata_2025_split huggingface dataset:
A bibliometric analysis of scientific literature in digital dentistry from low- and lower-middle income countries
Authors: Adnan Samira , Lal Abhishek , Naved Nighat , Umer Fahad 
Published: May 2024

Abstract
Objective
Bibliometric analysis and citation counts help to acknowledge influence of publications. The aim of this study was to conduct bibliometric and citation analysis of top-cited articles, from low- and lower-middle income countries, on use and application of digital technology in dentistry.

Methodology
A search strategy based on “Digital Dentistry”, “Low Income Countries”, and “Lower-Middle Income Countries” was used in October 2023 using Scopus database to retrieve articles relevant to digital dentistry, with citation count of 10 or more. From 44 included articles, bibliometric information was analyzed on SPSS version 23. Network analysis based on co-citations, keywords, and number of citations was conducted on VOS software (version 1.6.20).

Results
Most relevant articles were published in 2021 (n = 8), with 52.3% original articles, out of which 40.9% were in vitro studies. India had the highest number of articles (n = 24), with most publications in The Journal of Indian Prosthodontic Society (n = 4), and in the domain of General Dentistry (n = 15, 34.1%). Co-authorship network analysis was not significant, but country-wise co-authorship analysis revealed India with the greatest link strength (4.0). Highest occurring keyword was 3D printing (link strength 5.0), and the citation analysis revealed Journal of Prosthetic Dentistry with the most number of published documents (3), having a citation count of 275. Bibliographic coupling for sources revealed Journal of Indian Prosthodontic Society to have the highest link strength of 15.33.

Conclusion
This analysis uncovers interesting bibliometric and citation based information including key thematic trends, emphasizing crucial role of technologies like 3D printing, CAD/CAM, and CBCT in digital dentistry. The study underscores the imperative for increased original research efforts in low- and lower middle-income countries.
Timing and co-occurrence of symptoms prior to a diagnosis of light chain (AL) amyloidosis
Authors: Singh Ashima , Szabo Aniko , Lian Qinghua , Pezzin Liliana , Sparapani Rodney , D’Souza Anita 
Published: May 2024

AbstractIt is well-established that most patients with systemic light chain (AL) amyloidosis have multi-organ involvement and are often diagnosed after a lag period of increasing symptoms. We leverage electronic health record (EHR) data from the TriNetX research network to describe the incidence, timing, and co-occurrence of precursor conditions of interests in a cohort of AL amyloidosis patients identified between October 2015-December 2020. Nineteen precursor diagnoses of interest representing features of AL amyloidosis were identified using ICD codes up to 36 months prior to AL amyloidosis diagnosis. Among 1,401 patients with at least 36 months of EHR data prior to AL amyloidosis diagnosis, 46% were females, 16% were non-Hispanic Black, and 6% were Hispanic. The median age was 71 (range, 21–91) years. The median number of precursor diagnoses was 5 with dyspnea and fatigue being the most prevalent. The time from the first occurrence of a precursor to AL diagnosis ranged from 3.2 to 21.4 months. Analyses of pairwise co-occurrence of specific diagnoses indicated a high association (Cole’s coefficient >0.6) among the examined precursor diagnoses. These findings provide novel information about the timing and co-occurrence of key precursor conditions and could be used to develop algorithms for early identification of AL amyloidosis.
Selective targeting of IRAK1 attenuates low molecular weight hyaluronic acid-induced stemness and non-canonical STAT3 activation in epithelial ovarian cancer
Authors: Standing David , Dandawate Prasad , Gunewardena Sumedha , Covarrubias-Zambrano Obdulia , Roby Katherine F. , Khabele Dineo , Jewell Andrea , Tawfik Ossama , Bossmann Stefan H. , Godwin Andrew K. , Weir Scott J. , Jensen Roy A. , Anant Shrikant 
Published: May 2024

AbstractAdvanced epithelial ovarian cancer (EOC) survival rates are dishearteningly low, with ~25% surviving beyond 5 years. Evidence suggests that cancer stem cells contribute to acquired chemoresistance and tumor recurrence. Here, we show that IRAK1 is upregulated in EOC tissues, and enhanced expression correlates with poorer overall survival. Moreover, low molecular weight hyaluronic acid, which is abundant in malignant ascites from patients with advanced EOC, induced IRAK1 phosphorylation leading to STAT3 activation and enhanced spheroid formation. Knockdown of IRAK1 impaired tumor growth in peritoneal disease models, and impaired HA-induced spheroid growth and STAT3 phosphorylation. Finally, we determined that TCS2210, a known inducer of neuronal differentiation in mesenchymal stem cells, is a selective inhibitor of IRAK1. TCS2210 significantly inhibited EOC growth in vitro and in vivo both as monotherapy, and in combination with cisplatin. Collectively, these data demonstrate IRAK1 as a druggable target for EOC.
Neuronal autosis is Na+/K+-ATPase alpha 3-dependent and involved in hypoxic-ischemic neuronal death
Authors: Depierre Pauline , Ginet Vanessa , Truttmann Anita C. , Puyal Julien 
Published: May 2024

AbstractMacroautophagy (hereafter called autophagy) is an essential physiological process of degradation of organelles and long-lived proteins. The discovery of autosis, a Na+/K+-ATPase (ATP1)-dependent type of autophagic cell death with specific morphological and biochemical features, has strongly contributed to the acceptance of a pro-death role of autophagy. However, the occurrence and relevance of autosis in neurons has never been clearly investigated, whereas we previously provided evidence that autophagy mechanisms could be involved in neuronal death in different in vitro and in vivo rodent models of hypoxia-ischemia (HI) and that morphological features of autosis were observed in dying neurons following rat perinatal cerebral HI. In the present study, we demonstrated that neuronal autosis could occur in primary cortical neurons using two different stimulations enhancing autophagy flux and neuronal death: a neurotoxic concentration of Tat-BECN1 (an autophagy-inducing peptide) and a hypoxic/excitotoxic stimulus (mimicking neuronal death induced by cerebral HI). Both stimulations induce autophagic neuronal death (dependent on canonical autophagic genes and independent on apoptotic, necroptotic or ferroptotic pathways) with all morphological and biochemical (ATP1a-dependent) features of autosis. However, we demonstrated that autosis is not dependent on the ubiquitous subunit ATP1a1 in neurons, as in dividing cell types, but on the neuronal specific ATP1a3 subunit. We also provided evidence that, in different in vitro and in vivo models where autosis is induced, ATP1a3-BECN1 interaction is increased and prevented by cardiac glycosides treatment. Interestingly, an increase in ATP1a3-BECN1 interaction is also detected in dying neurons in the autoptic brains of human newborns with severe hypoxic-ischemic encephalopathy (HIE). Altogether, these results suggest that ATP1a3-BECN1-dependent autosis could play an important role in neuronal death in HI conditions, paving the way for the development of new neuroprotective strategies in hypoxic-ischemic conditions including in severe case of human HIE.
Synergizing habits and goals with variational Bayes
Authors: Han Dongqi , Doya Kenji , Li Dongsheng , Tani Jun 
Published: May 2024

AbstractBehaving efficiently and flexibly is crucial for biological and artificial embodied agents. Behavior is generally classified into two types: habitual (fast but inflexible), and goal-directed (flexible but slow). While these two types of behaviors are typically considered to be managed by two distinct systems in the brain, recent studies have revealed a more sophisticated interplay between them. We introduce a theoretical framework using variational Bayesian theory, incorporating a Bayesian intention variable. Habitual behavior depends on the prior distribution of intention, computed from sensory context without goal-specification. In contrast, goal-directed behavior relies on the goal-conditioned posterior distribution of intention, inferred through variational free energy minimization. Assuming that an agent behaves using a synergized intention, our simulations in vision-based sensorimotor tasks explain the key properties of their interaction as observed in experiments. Our work suggests a fresh perspective on the neural mechanisms of habits and goals, shedding light on future research in decision making.
Lateral parabrachial FoxP2 neurons regulate respiratory responses to hypercapnia
Authors: Kaur Satvinder , Lynch Nicole , Sela Yaniv , Lima Janayna D. , Thomas Renner C. , Bandaru Sathyajit S. , Saper Clifford B. 
Published: May 2024

AbstractAbout half of the neurons in the parabrachial nucleus (PB) that are activated by CO2 are located in the external lateral (el) subnucleus, express calcitonin gene-related peptide (CGRP), and cause forebrain arousal. We report here, in male mice, that most of the remaining CO2-responsive neurons in the adjacent central lateral (PBcl) and Kölliker-Fuse (KF) PB subnuclei express the transcription factor FoxP2 and many of these neurons project to respiratory sites in the medulla. PBclFoxP2 neurons show increased intracellular calcium during wakefulness and REM sleep and in response to elevated CO2 during NREM sleep. Photo-activation of the PBclFoxP2 neurons increases respiration, whereas either photo-inhibition of PBclFoxP2 or genetic deletion of PB/KFFoxP2 neurons reduces the respiratory response to CO2 stimulation without preventing awakening. Thus, augmenting the PBcl/KFFoxP2 response to CO2 in patients with sleep apnea in combination with inhibition of the PBelCGRP neurons may avoid hypoventilation and minimize EEG arousals.
Electrostatically controlled spin polarization in Graphene-CrSBr magnetic proximity heterostructures
Authors: Yang Boxuan , Bhujel Bibek , Chica Daniel G. , Telford Evan J. , Roy Xavier , Ibrahim Fatima , Chshiev Mairbek , Cosset-Chéneau Maxen , Wees Bart J. van 
Published: May 2024

AbstractThe magnetic proximity effect can induce a spin dependent exchange shift in the band structure of graphene. This produces a magnetization and a spin polarization of the electron/hole carriers in this material, paving the way for its use as an active component in spintronics devices. The electrostatic control of this spin polarization in graphene has however never been demonstrated so far. We show that interfacing graphene with the van der Waals antiferromagnet CrSBr results in an unconventional manifestation of the quantum Hall effect, which can be attributed to the presence of counterflowing spin-polarized edge channels originating from the spin-dependent exchange shift in graphene. We extract an exchange shift ranging from 27 – 32 meV, and show that it also produces an electrostatically tunable spin polarization of the electron/hole carriers in graphene ranging from − 50% to + 69% in the absence of a magnetic field. This proof of principle provides a starting point for the use of graphene as an electrostatically tunable source of spin current and could allow this system to generate a large magnetoresistance in gate tunable spin valve devices.
9-fold symmetry is not essential for centriole elongation and formation of new centriole-like structures
Authors: Panda Pallavi , Ladinsky Mark S. , Glover David M. 
Published: May 2024

AbstractAs daughter centrioles assemble during G2, they recruit conserved Ana3/RTTN followed by its partner Rcd4/PPP1R35. Together, this contributes to the subsequent recruitment of Ana1/CEP295, required for the centriole’s conversion to a centrosome. Here, we show that Rcd4/PPP1R35 is also required to maintain 9-fold centriole symmetry in theDrosophilamale germline; its absence causes microtubule triplets to disperse into a reduced number of doublet or singlet microtubules.rcd4-null mutant spermatocytes display skinny centrioles that elongate normally and localize centriolar components correctly. Mutant spermatocytes also have centrioles of normal girth that splay at their proximal ends when induced to elongate by Ana1 overexpression. Skinny and splayed spermatid centrioles can still recruit a proximal centriole-like (PCL) structure marking a capability to initiate features of centriole duplication in developing sperm. Thus, stable 9-fold symmetry of microtubule triplets is not essential for centriole growth, correct longitudinal association of centriole components, and aspects of centriole duplication.
Early aerial expedition photos reveal 85 years of glacier growth and stability in East Antarctica
Authors: Dømgaard Mads , Schomacker Anders , Isaksson Elisabeth , Millan Romain , Huiban Flora , Dehecq Amaury , Fleischer Amanda , Moholdt Geir , Andersen Jonas K. , Bjørk Anders A. 
Published: May 2024

AbstractDuring the last few decades, several sectors in Antarctica have transitioned from glacial mass balance equilibrium to mass loss. In order to determine if recent trends exceed the scale of natural variability, long-term observations are vital. Here we explore the earliest, large-scale, aerial image archive of Antarctica to provide a unique record of 21 outlet glaciers along the coastline of East Antarctica since the 1930s. In Lützow-Holm Bay, our results reveal constant ice surface elevations since the 1930s, and indications of a weakening of local land-fast sea-ice conditions. Along the coastline of Kemp and Mac Robertson, and Ingrid Christensen Coast, we observe a long-term moderate thickening of the glaciers since 1937 and 1960 with periodic thinning and decadal variability. In all regions, the long-term changes in ice thickness correspond with the trends in snowfall since 1940. Our results demonstrate that the stability and growth in ice elevations observed in terrestrial basins over the past few decades are part of a trend spanning at least a century, and highlight the importance of understanding long-term changes when interpreting current dynamics.
Synergetic regulation of SEI mechanics and crystallographic orientation for stable lithium metal pouch cells
Authors: Zhang Yanhua , Qiao Rui , Nie Qiaona , Zhao Peiyu , Li Yong , Hong Yunfei , Chen Shengjie , Li Chao , Sun Baoyu , Fan Hao , Deng Junkai , Xie Jingying , Liu Feng , Song Jiangxuan 
Published: May 2024

AbstractThe advancement of Li-metal batteries is significantly impeded by the presence of unstable solid electrolyte interphase and Li dendrites upon cycling. Herein, we present an innovative approach to address these issues through the synergetic regulation of solid electrolyte interphase mechanics and Li crystallography using yttrium fluoride/polymethyl methacrylate composite layer. Specifically, we demonstrate the in-situ generation of Y-doped lithium metal through the reaction of composite layer with Li metal, which reduces the surface energy of the (200) plane, and tunes the preferential crystallographic orientation to (200) plane from conventional (110) plane during Li plating. These changes effectively passivate Li metal, thereby significantly reducing undesired side reactions between Li and electrolytes by 4 times. Meanwhile, the composite layer with suitable modulus (~1.02 GPa) can enhance mechanical stability and maintain structural stability of SEI. Consequently, a 4.2 Ah pouch cell with high energy density of 468 Wh kg−1 and remarkable capacity stability of 0.08% decay/cycle is demonstrated under harsh condition, such as high-areal-capacity cathode (6 mAh cm−2), lean electrolyte (1.98 g Ah−1), and high current density (3 mA cm−2). Our findings highlight the potential of reactive composite layer as a promising strategy for the development of stable Li-metal batteries.
A conserved Pol II elongator SPT6L mediates Pol V transcription to regulate RNA-directed DNA methylation in Arabidopsis
Authors: Liu Yujuan , Shu Jie , Zhang Zhi , Ding Ning , Liu Jinyuan , Liu Jun , Cui Yuhai , Wang Changhu , Chen Chen 
Published: May 2024

AbstractIn plants, the plant-specific RNA polymerase V (Pol V) transcripts non-coding RNAs and provides a docking platform for the association of accessory proteins in the RNA-directed DNA methylation (RdDM) pathway. Various components have been uncovered that are involved in the process of DNA methylation, but it is still not clear how the transcription of Pol V is regulated. Here, we report that the conserved RNA polymerase II (Pol II) elongator, SPT6L, binds to thousands of intergenic regions in a Pol II-independent manner. The intergenic enrichment of SPT6L, interestingly, co-occupies with the largest subunit of Pol V (NRPE1) and mutation of SPT6L leads to the reduction of DNA methylation but not Pol V enrichment. Furthermore, the association of SPT6L at Pol V loci is dependent on the Pol V associated factor, SPT5L, rather than the presence of Pol V, and the interaction between SPT6L and NRPE1 is compromised in spt5l. Finally, Pol V RIP-seq reveals that SPT6L is required to maintain the amount and length of Pol V transcripts. Our findings thus uncover the critical role of a Pol II conserved elongator in Pol V mediated DNA methylation and transcription, and shed light on the mutual regulation between Pol V and II in plants.
Enhancement of phase transition temperature through hydrogen bond modification in molecular ferroelectrics
Authors: Xiong Yu-An , Duan Sheng-Shun , Hu Hui-Hui , Yao Jie , Pan Qiang , Sha Tai-Ting , Wei Xiao , Ji Hao-Ran , Wu Jun , You Yu-Meng 
Published: May 2024

AbstractMolecular ferroelectrics are attracting great interest due to their light weight, mechanical flexibility, low cost, ease of processing and environmental friendliness. These advantages make molecular ferroelectrics viable alternatives or supplements to inorganic ceramics and polymer ferroelectrics. It is expected that molecular ferroelectrics with good performance can be fabricated, which in turns calls for effective chemical design strategies in crystal engineering. To achieve so, we propose a hydrogen bond modification method by introducing the hydroxyl group, and successfully boost the phase transition temperature (Tc) by at least 336 K. As a result, the molecular ferroelectric 1-hydroxy-3-adamantanammonium tetrafluoroborate [(HaaOH)BF4] can maintain ferroelectricity until 528 K, a Tc value much larger than that of BTO (390 K). Meanwhile, micro-domain patterns, in stable state for 2 years, can be directly written on the film of (HaaOH)BF4. In this respect, hydrogen bond modification is a feasible and effective strategy for designing molecular ferroelectrics with high Tc and stable ferroelectric domains. Such an organic molecule with varied modification sites and the precise crystal engineering can provide an efficient route to enrich high-Tc ferroelectrics with various physical properties.
Rab30 facilitates lipid homeostasis during fasting
Authors: Smith Danielle M. , Liu Brian Y. , Wolfgang Michael J. 
Published: May 2024

AbstractTo facilitate inter-tissue communication and the exchange of proteins, lipoproteins, and metabolites with the circulation, hepatocytes have an intricate and efficient intracellular trafficking system regulated by small Rab GTPases. Here, we show that Rab30 is induced in the mouse liver by fasting, which is amplified in liver-specific carnitine palmitoyltransferase 2 knockout mice (Cpt2L−/−) lacking the ability to oxidize fatty acids, in a Pparα-dependent manner. Live-cell super-resolution imaging and in vivo proximity labeling demonstrates that Rab30-marked vesicles are highly dynamic and interact with proteins throughout the secretory pathway. Rab30 whole-body, liver-specific, and Rab30; Cpt2 liver-specific double knockout (DKO) mice are viable with intact Golgi ultrastructure, although Rab30 deficiency in DKO mice suppresses the serum dyslipidemia observed in Cpt2L−/− mice. Corresponding with decreased serum triglyceride and cholesterol levels, DKO mice exhibit decreased circulating but not hepatic ApoA4 protein, indicative of a trafficking defect. Together, these data suggest a role for Rab30 in the selective sorting of lipoproteins to influence hepatocyte and circulating triglyceride levels, particularly during times of excessive lipid burden.
Undetected perovskite phase interference with zirconolite dissolution measurements
Authors: Goût Thomas L. , Mir Anamul H. , Fairclough Simon M. , Pletser Dimitri , Farnan Ian 
Published: May 2024

AbstractZirconolite ceramics present a chemically durable host matrix for waste actinides, but zirconolite dissolution rates reported in the literature often vary significantly. Here, the release of Ca and Al from a hot isostatically pressed zirconolite (Ca0.8Zr0.9Ce0.3Ti1.6Al0.4O7.0) was shown to be predominantly driven by preferential dissolution of minor perovskite and alumina phases. Both phases were undetectable by XRD, and the perovskite was difficult to detect by SEM-EDS. Whilst the zirconolite phase exhibited no signs of alteration, dissolution of the perovskite proceeded congruently without forming a hydrated altered layer or diffusion of protons into the solid that would be indicative of an ion-exchange mechanism. The weak temperature dependence of dissolution (40, 90 and 150 °C) showed that kinetics were limited by transport and a mixed transport-surface controlled reaction for Ca and Al, respectively. A significant H2O-D2O isotope effect on dissolution was observed for Ca but not for Al at all temperatures. The former was consistent with an abated rate of hydrolysis in the absence of a contribution from diffusion, whilst the latter could be attributed to differences in the activated complex for Ca and Al release through hydrolysis. These results demonstrate the role of a secondary phase perovskite in the dissolution kinetics of zirconolite even when perovskite occurs at low concentration and evades detection by bulk techniques such as XRD. This study provides a potential explanation of variations in zirconolite ceramic dissolution rates present in the literature and provides a null result to tests of an incongruent Ca release mechanism from zirconolite.
Relationship between obstructive sleep apnoea syndrome and gastrointestinal diseases: a systematic review and Meta-analysis
Authors: Cao Liubin , Zhou Chengpei , Zhang Rupei , Zhou Shan , Sun Xiaolei , Yan Jun 
Published: May 2024

AbstractStudies exploring the association between obstructive sleep apnoea syndrome (OSA) and gastrointestinal diseases (GID) are important for enhancing clinical outcomes. This study aimed to systematically assess the association between these two diseases. Adhering to PRISMA guidelines, a comprehensive literature search was conducted across databases including PubMed, Web of Science, Willey Library, Cochrane Library and Scopus. This search focused on English literature published up to January 2024. Literature screening, quality assessment (using the NOS scale) and data extraction were performed by two independent researchers. Statistical analyses were performed using the meta-package of the R.4.2.2 software. An initial screening of 2178 papers was conducted and 11 studies were included. Meta-analysis results showed a significant association between OSA and GID (p < 0.01). Subgroup analyses further indicated a stronger association between OSA and GID in Asian populations compared to Europe and the United States. In addition, both benign and malignant GID were significantly associated with OSA, with a pronounced association for malignant GID than for benign GID. The results of publication bias analysis revealed no significant bias (Begg’s test p = 0.45, Egger’s test p = 0.60). This study uncovers a notable association between OSA and GID, especially in Asian populations, suggesting that clinicians should consider the potential connection between these two diseases during diagnosis and treatment. However, due to the heterogeneity and limitations of the study, these conclusions need to be further validated through more comprehensive research.