bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antiviral activity of temporin-1CEb analogues against gingival infection with herpes simplex virus type 1
Authors: Golda Anna , Kosikowska-Adamus Paulina , Wadowska Marta , Dobosz Ewelina , Potempa Jan , Koziel Joanna 
Published: June 2024

IntroductionOral herpes infections caused by herpes simplex virus type 1 (HSV-1) are one of the most common in the human population. Recently, they have been classified as an increasing problem in immunocompromised patients and those suffering from chronic inflammation of the oral mucosa and gums. Treatment mainly involves nucleoside analogues, such as acyclovir and its derivatives, which reduce virus replication and shedding. As drug-resistant strains of herpes emerge rapidly, there is a need for the development of novel anti-herpes agents. The aim of the study was to design an antiviral peptide, based on natural compounds, non-toxic to the host, and efficient against drug-resistant HSV-1. Here, we designed a lysine-rich derivative of amphibian temporin-1CEb conjugated to peptides penetrating the host cell membrane and examined their activity against HSV-1 infection of oral mucosa.MethodsWe assessed the antiviral efficiency of the tested compound in simple 2D cell models (VeroE6 and TIGKs cells) and a 3D organotypic model of human gingiva (OTG) using titration assay, qPCR, and confocal imaging. To identify the molecular mechanism of antiviral activity, we applied the Azure A metachromatic test, and attachment assays techniques. Toxicity of the conjugates was examined using XTT and LDH assays.ResultsOur results showed that temporin-1CEb analogues significantly reduce viral replication in oral mucosa. The mechanism of peptide analogues is based on the interaction with heparan sulfate, leading to the reduce attachment of HSV-1 to the cell membrane. Moreover, temporin-1CEb conjugates effectively penetrate the gingival tissue being effective against acyclovir-resistant strains. Collectively, we showed that temporin-1CEb can be regarded as a novel, naturally derived antiviral compound for HSV-1 treatment.
The first report of single nucleotide polymorphisms in the open reading frame of the prion-like protein gene in rabbits
Authors: Jeong Min-Ju , Kim Yong-Chan , Jeong Byung-Hoon 
Published: June 2024

BackgroundNatural cases of prion disease have not been reported in rabbits, and prior attempts to identify a prion conversion agent have been unsuccessful. However, recent applications of prion seed amplifying experimental techniques have sparked renewed interest in the potential susceptibility of rabbits to prion disease infections. Among several factors related to prion disease, polymorphisms within the prion-like protein gene (PRND), a member of the prion protein family, have been reported as significantly associated with disease susceptibility in various species. Therefore, our study aimed to investigate polymorphisms in the PRND gene of rabbits and analyze their genetic characteristics.MethodsGenomic DNA was extracted from 207 rabbit samples to investigate leporine PRND polymorphisms. Subsequently, amplicon sequencing targeting the coding region of the leporine PRND gene was conducted. Additionally, linkage disequilibrium (LD) analysis was employed to assess the connection within and between loci. The impact of non-synonymous single nucleotide polymorphisms (SNPs) on the Doppel protein was evaluated using PolyPhen-2.ResultsWe found nine novel SNPs in the leporine PRND gene: c.18A &gt; G, c.76G &gt; C, c.128C &gt; T, c.146C &gt; T, c.315A &gt; G, c.488G &gt; A, c.525G &gt; C, c.544G &gt; A, and c.579A &gt; G. Notably, seven of these PRND SNPs, excluding c.525G &gt; C and c.579A &gt; G, exhibited strong LD values exceeding 0.3. In addition, LD analysis confirmed a robust link between PRNP SNP c.234C &gt; T and PRND SNPs at c.525G &gt; C and c.579A &gt; G. Furthermore, according to PolyPhen-2 and SIFT analyses, the four non-synonymous SNPs were predicted to have deleterious effects on the function or structure of the Doppel protein. However, PANTHER and Missense3D did not indicate such effects.ConclusionIn this paper, we have identified novel SNPs in the rabbit PRND gene and predicted their potential detrimental effects on protein function or structure through four non-synonymous SNPs. Additionally, we observed a genetic linkage between SNPs in the PRND and PRNP genes. These findings may provide insights into understanding the characteristics of rabbits as partially resistant species. To the best of our knowledge, this study is the first to genetically characterize PRND SNPs in rabbits.
Limitations of Transversus Abdominis Release (TAR)—Additional Bridging of the Posterior Layer And/Or Anterior Fascia Is the Preferred Solution in Our Clinical Routine If Primary Closure is Not Possible
Authors: Riediger Hartwig , Köckerling Ferdinand 
Published: June 2024

Background: By separating the abdominal wall, transversus abdominis release (TAR) permits reconstruction of the abdominal wall and the placement of large mesh for many types of hernias. However, in borderline cases, the mobility of the layers is inadequate, and additional bridging techniques may be required for tension-free closure. We now present our own data in this regard.Patients and Methods: In 2023, we performed transversus abdominis release on 50 patients as part of hernia repair. The procedures were carried out using open (n = 25), robotic (n = 24), and laparoscopic (n = 1) techniques. The hernia sac was always integrated into the anterior suture and, in the case of medial hernias, was used for linea alba reconstruction.Results: For medial hernias, open TAR was performed in 22 cases. Additional posterior bridging was performed in 7 of these cases. The ratio of mesh size in the TAR plane to the defect area (median in cm) was 1200cm2/177 cm2 = 6.8 in patients without bridging, and 1750cm2/452 cm2 = 3.8 in those with bridging. The duration of surgery (median in min) was 139 and 222 min and the hospital stay was 6 and 10 days, respectively. Robotic TAR was performed predominantly for lateral and parastomal hernias. These procedures took a median of 143 and 242 min, and the hospital stay was 2 and 3 days, respectively. For robotic repair, posterior bridging was performed in 3 cases.Discussion: Using the TAR technique, even complex hernias can be safely repaired. Additional posterior bridging provides a reliable separation of the posterior plane from the intestines. Therefore, the hernia sac is always available for anterior reconstruction of the linea alba. The technique can be implemented as an open or minimally invasive procedure.
«The Space of the Saints» as a Feature of the Sacred Geography in Late Antiquity (Using the Example of Egypt)
Authors: Войтенко А.В. 
Published: June 2024

В статье предпринято исследование типов христианских сакральных пространств в период поздней Античности. Автор статьи считает храм (церковь) и монастырь наиболее адекватными типами таких пространств в социологическом плане. Однако в поздней Античности к ним присоединяется еще один феномен, который можно обозначить как «пространство святых». Этот феномен имел два типа: пространство, сформированное вокруг мощей святых (прежде всего мучеников), и «cиловое поле», образуемое вокруг живых святых (прежде всего монахов). В поздней Античности, как представляется автору статьи, это пространство обладало определенной автономией по отношению к храму и монастырю. Причины этого феномена лучше всего объясняет П. Браун: в условиях эрозии старых (античных) структур и только еще кристаллизации новых (средневековых) «локус» сверхъестественного в общественных представлениях переходит к отдельным людям. Соответственно, при окончательной институционализации новых «безличных агентов» пространство святых потеряло свою автономность и встроилось в сакральное пространство храма или монастыря.
The article focuses on a study of the types of Christian sacred spaces (sacra spatia) during the period of late Antiquity. The author considers the identification of a temple (a church) and a monastery as the most adequate types of sacra spatia in sociological context. However, in late Antiquity they were joined by another phenomenon, which can be designated as the «space of the saints» (spatio sanctorum). This phenomenon had two types: a space formed around the relics of saints or «dead saints» (primarily martyrs), and a «force field» (locus potestatis) formed around living saints or «holy men» (primarily monks). In late Antiquity, this space seems to have a certain autonomy in relation to a church and a monastery. The reasons for this phenomenon are best explained by Peter Brown: in conditions of erosion of old (antique) structures and only rising new (medieval) ones, the locus of the supernatural in public oppinions passed to an individual man. Accordingly, with the final institutionalization of new «impersonal agents», the space of saints has lost its autonomy and been integrated into the sacred space of a church or a monastery.
Рilgrimage of Nil Sorskyto the Christian East
Authors: Романенко Е.В. 
Published: June 2024

В статье реконструируется маршрут паломничества Нила Сорского на Восток, предпринятого им в начале 80-х годов XV в. В своих сочинениях русский святой свидетельствовал, что посещал Константинополь и Афон. Автор статьи приводит ряд аргументов в пользу того, что Нил Сорский, возможно, побывал в Палестине и на Синае. Вернувшись на Русь, он переписал и отредактировал более 20 житий древних святых, и опыт паломничества помогал ему в этой работе. Множество исправлений и уточнений он внес в тексты, опираясь на уже знакомые ему реалии. Собранные вместе жития образовали знаменитый «Соборник» Нила Сорского,. В статье поднимается вопрос об авторской структуре этого фундаментального труда. Скорее всего, первоначальной замысел Нила Сорского воплощен в рукописях Гурия (Тушина), монаха Кирилло-Белозерского монастыря, который в 1508/09 годах, сразу после смерти Нила Сорского, сделал копии «Соборника» в 2 книгах. Отличительной особенностью этих копий является включение в их состав «мучений» и «Слов» святых отцов. Тушинский сборник РНБ. Кир.-Бел. № 141/1218 открывает Повесть монаха Аммония о убиении святых отцов в Синае и Раифе. Ее наличие в первоначальном варианте «Соборника», возможно, связано с посещением преподобным Нилом этих мест.
Рilgrimage of Nil Sorsky to the Christian East The article reconstructs the pilgrimage route of Nil Sorsky to the East, which he undertook in the early 80s of the 15th century. In his essays, the Russian saint testified that he visited Constantinople and Athos. The author of the article gives a number of arguments in favor of the fact that Nil Sorsky may have visited Palestine and Sinai. Upon his return to Rus, he rewrote and edited more than 20 lives of ancient saints, and the experience of pilgrimage helped him in this work. He made many corrections and clarifications to the texts, based on realities already familiar to him. The lives collected together formed the famous «Sobornik» («Collection») of Nil Sorsky. The article raises the question of the author's structure of this fundamental work. Most likely, the original plan of Nil Sorsky was embodied in the manuscripts of Gury (Tushin), a monk of the Kirillo-Belozersky Monastery, who made copies of the «Sobornik» in 2 books in 1508/09, immediately after the death of Nil Sorsky. A distinctive feature of these copies is the inclusion in their composition of the «torment» and «Words» of the holy fathers. The Tale of the monk Ammonius about the murder of the holy fathers in Sinai and Raifa opens Tushin’s collection of the Russian National Library. Kir.-Bel., №. 141/1218. Its presence in the original version of the «Sobornik» may be associated with the visit of the reverend Nil to these places.
The Gate of the Kaaba: Damascus and the Syrian Hajj Route in the Sacred Geography of Ottoman Syria from the 16th to the 19th Centuries
Authors: Жантиев Д.Р. 
Published: June 2024

В статье анализируются взаимосвязи между ролью Дамаска как одного из двух важнейших отправных пунктов маршрутов хаджа и восприятием города как сакрального пространства в османскую эпоху. Особое внимание уделяется традиции организации османскими властями сирийского каравана хаджа, монументальному строительству в Дамаске религиозных сооружений при попечительстве османских властей, а также распространению практики почитания гробниц суфийских шейхов и святых. На протяжении четырех веков османского господства над Сирией (1516—1918) османские правители расценивали сирийский маршрут хаджа как продолжение «Султанской дороги» от Стамбула до Дамаска, который, в свою очередь, воспринимался в качестве «Врат Каабы». Османские вакуфные комплексы XVI в. в Дамаске органично соседствовали с более старинными постройками и сыграли особо значимую роль в «османизации» сакрального пространства города как в институциональном, так и в пространственно-визуальном плане. Давняя традиция посещения прибывающими в Дамаск паломниками Омейядской мечети с ее реликвиями стала дополняться посещением могилы «Величайшего шейха» Ибн Араби и величественных османских мечетей, возведенных при попечении султанов и их наместников. Особую роль в расширении сакральной географии Дамаска в османскую эпоху играли суфийские братства. Контроль над Дамаском как отправным пунктом хаджа способствовал поддержанию и укреплению авторитета османских султанов как халифов и хранителей исламских святынь Мекки и Медины.
The article explores the connections between Damascus's role as one of the two main starting points for the Hajj routes and its reputation as a sacred ground during the Ottoman period. Special attention is given to the Ottoman authorities' tradition of organizing the Syrian Hajj caravan, the monumental construction of religious buildings in Damascus under Ottoman patronage, and the widespread practice of venerating the tombs of Sufi sheikhs and saints. Over four centuries of Ottoman rule in Syria (1516-1918), the Ottoman rulers viewed the Syrian Hajj route as an extension of the 'Sultan's Road' from Istanbul to Damascus, which was in turn seen as the 'Gate of the Kaaba'. Ottoman waqf complexes from the 16th century in Damascus blended seamlessly with older structures and played a crucial role in the «Ottomanization» of the city's sacred spaces, both institutionally and in terms of their spatial and visual impact. The longstanding tradition of pilgrims visiting the Umayyad Mosque and its relics upon arriving in Damascus was enriched by visits to the tomb of 'The Greatest Sheikh' Ibn Arabi and the grand Ottoman mosques built under the supervision of the sultans and their viceroys. Sufi brotherhoods played a pivotal role in expanding the sacred geography of Damascus during the Ottoman era. Control over Damascus as the starting point for the Hajj contributed to maintaining and strengthening the authority of the Ottoman sultans as caliphs and guardians of the Islamic holy sites of Mecca and Medina.
The February Revolution in Moscow Through Observations, Rumors, and Dialogues. Based on the Diaries of N.P. Vishnyakov
Authors: Хутарев-Гарнишевский В.В. 
Published: June 2024

Ход Февральской революции в Москве является одним из «белых пятен» в истории падения монархии в России. В связи с тем, что основные события революции происходили в Петрограде, Могилеве и Пскове, политическая и общественная жизни Москвы февраля – марта 1917 года оказалась мало изучена историками. Данная статья представляет собой публикацию отрывков из двух рукописей гласного городской думы Николая Петровича Вишнякова: «Автобиографических заметок» и «Думских воспоминаний и впечатлений». Приводимые записи датируются 21 февраля – 31 марта 1917 года. Первая часть записей носит описательный характер, воссоздает атмосферу тех дней. Вторая часть написана вскоре после революции и представляет собой первые попытки анализа причин падения монархии. Представляет интерес описание городской жизни, зарисовки быта, невероятных слухов, массовых настроений и волнений, охвативших Москву. Вишняков приводит характеристики некоторых деятелей революции, например, министра Временного правительства Николая Кишкина и московского городского головы Николая Астрова. В публикации приведены диаметрально противоположные оценки, данные революции двумя близкими автору людьми: известным историком, академиком Владимиром Герье и оренбургским губернатором генералом Михаилом Тюлиным. Публикация продолжает издание эпистолярного наследия Вишнякова, начатого в 38-ом томе журнала «Исторический вестник».
The Moscow events of the February Revolution remain a «blank spot» in the history of the monarchy's downfall in Russia. Given that the main events of the revolution took place in Petrograd, Mogilev, and Pskov, the political and social life of Moscow during February and March 1917 has been scarcely studied by historians. This article publishes excerpts from two manuscripts by Nikolai Vishnyakov, a vocal member of the City Duma: «Autobiographical Notes» and «Duma Memories and Impressions». The entries provided are dated from February 21 to March 31, 1917. The initial part of the records is descriptive, vividly capturing the atmosphere of that days. The latter part, written shortly after the revolution, attempts to analyze the causes of the monarchy's downfall. The description of city life, everyday scenes, wild rumors, and the widespread unrest that swept through Moscow is of particular interest. Vishnyakov offers insights into various revolutionary figures, including Provisional Government Minister Nikolai Kishkin and Moscow Mayor Nikolai Astrov. The publication offers contrasting assessments of the revolution from two acquaintances of the author: distinguished historian and academician Vladimir Guerrier and Orenburg Governor General Mikhail Tyulin. The publication continues the unveiling of Vishnyakov's collection of letters, commenced in the 38th volume of the Historical Reporter.
Addition of Caulerpa racemosa on Commercial Goldfish Ornamental Fish Feed to Increase Color Saturation
Authors: Ngangi Edwin L. A. , Longdong Sammy N.J. , Mudeng Joppy D. 
Published: June 2024

The brightness and high color saturation determine the selling price of ornamental goldfish. Color saturation is the color intensity visible to the naked eye from the appearance of goldfish. Caulerpa racemosa seaweed contains β-carotene, a type of carotenoid that is a red, yellow, and orange pigment. The research aimed to determine the effectiveness of adding C. racemosa flour to artificial goldfish (Carrasius auratus) feed. The experimental design used was three treatments of adding C. racemosa flour to artificial feed, namely 0%, 1%, and 1.5%. The experiment was carried out for 45 days with intensive fish care in an aquarium. Observation of color intensity using M-TCF (toca color finder) at the beginning and end of the study by three panelists. The results showed that increasing the color saturation of goldfish with the addition of 1.5% C. recomosa seaweed flour gave the best results.
Caulerpa racemosa; Carrasius auratus; artificial feed; carotenoids; M-TCF.
Abstrak
Nilai jual ikan hias mas koki salah satunya ditentukan oleh kecerahan dan tingginya saturasi warna. Saturasi warna merupakan intensitas warna yang secara kasat mata tampak dari performans ikan mas koki. Rumput laut Caulerpa racemosa mengandung β-karoten yaitu jenis karotenoid yang merupakan zat pigmen warna merah, kuning dan jingga. Tujuan penelitian untuk mengetahui efektifiktas tepung C. racemosa yang ditambahkan pada pakan artifisial untuk ikan mas koki (Carrasius auratus). Rancangan percobaan yaitu 3 perlakuan penambahan tepung C. racemosa pada pakan artifisial: 0%, 1%, dan 1,5%. Percobaan dilakukan selama 45 hari dengan perawatan ikan secara intensif dalam akuarium. Pengamatan intensitas warna menggunakan M-TCF (toca color finder) pada warna awal dan warna akhir penelitian oleh 3 panelis. Hasil penelitian menunjukkan bahwa peningkatan saturasi warna ikan mas koki dengan penambahan tepung rumput laut C. recomosa sebanyak 1,5% memberikan hasil terbaik.
Kata kunci: Caulerpa racemosa; Carrasius auratus; pakan artifisial; karotenoid; M-TCF.
Demonstrasi dan Peningkatan Keterampilan Ibu dalam Pengolahan Makanan Kudapan Pendamping ASI Berbasis Pangan Lokal
Authors: Syah Justiyulfah , Abdullah Anisa Dwirizky , Fauziah Fauziah , Rahmaniah Rahmaniah , Sari Riska Mayang , Zakiah Nur 
Published: June 2024

Angka stunting Polewali Mandar hingga Tahun 2022 berdasarkan data nasional masih menunjukkan masalah yang cukup tinggi. Desa Nepo kecamatan Wonomulyo merupakan salah satu desa yang berada di, Kabupaten Polewali Mandar, Sulawesi Barat, Indonesia. Alternatif pencegahan dan penanganan stunting ialah dengan perbaikan gizi dengan meningkatkan pengetahuan ibu tentang pengaturan makanan bergizi untuk balita serta pemanfaatan bahan pangan lokal. Tujuan dari pelaksanaan program pengabdian kepada masyarakat ini adalah pemberdayaan masyarakat dalam upaya pencegahan stunting melalui peningkatkan pengetahuan dan keterampilan untuk mengolah ikan tuna sebagai bahan pangan lokal menjadi olahan kudapan pendamping ASI bernilai gizi tinggi. Metode yang digunakan dalam pengabdian masyarakat ini adalah dengan penyuluhan menggunakan metode ceramah dan diskusi dengan media lembar balik. Kegiatan ini dapat meningkatkan keterampilan pengolahan pangan lokal berbasis ikan tuna menggunakan metode demonstrasi pembuatan kudapan. Hasil yang diharapkan dari kegiatan ini adalah terjadi peningkatan pengetahuan dan meningkatkan keterampilan ibu dalam penggunaan pangan lokal berbasis ikan tuna.
Komposisi Gender Dan Tingkat Pendidikan Pada Manajemen Level Dan Pengaruhnya Pada Profitabilitas Perusahaan
Authors: Gunawan Moses 
Published: June 2024

Gender diversity and education level of management level is one from many issues that raised where companies are continually innovating and seeking the best ways to generate higher profit through years. Therefore this research aims to find evidence of whether there is an influence of gender diversity and education level on the increase of companyâ€™s profitability, which is studied through descriptive analysis by reviewing the literature from 15 studies obtained from google scholar and emerald insight. The result was found that the gender composition and the level of education do not have a direct impact on a company's profitability but rather depend on how the company can maximize them to get more benefits from the existency of woman on the companyyâ€™s management level job.

Keywords: Gender Diversity, Education level, and Profitability