bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental implementation of Super-Twisting Based High Order Sliding Mode Control for MCT driven DFIG-DC energy conversion system
Authors: Smai Yosra , Azza Hechmi Ben , Touaiti Bilel , Boussak Mohamed , Jemli Mohamed 
Published: June 2024

Abstract

This paper develops a High Order Sliding Mode Control for energy conversion system DC-link based on DFIG. In the studied system, a bridge rectifier ensures the connection between the stator windings and the DC bus, while a PWM power converter is placed between the DC bus and the rotor windings. The proposed topology presents the most appropriate solution which allows to connect marine renewable energy farms to the High Voltage Direct Current transmission systems. Unfortunately, the major drawback of the energy conversion system DC-link based on DFIG is the highly distorted stator voltage due to the bridge rectifier on stator side. So, in order to regulate the DC voltage and the stator frequency with harmonic current suppression, this paper includes the development of super-twisting sliding mode algorithm for a stand-alone DFIG-DC system which is used in a tidal stream turbine. Indeed, to improve the quality of stator currents, reference rotor harmonic currents are calculated and injected with the fundamental d and q-axis reference rotor currents. Finally, the performances of the DFIG-DC energy conversion system are shown through digital simulation and experimental results. These results give high dynamic performances of the DC voltage regulation and the reduction capability of the harmonics.
Semi-field evaluation of electrocuting eave tubes for the control of endophagic mosquitoes in south-east Tanzania
Authors: Shirima Ruth S. , Katusi Godfrey C. , Mmbando Arnold S. , Fanuel Gracious , Knols Bart G.J. , Okumu Fredros O. , Kaindoa Emmanuel W. 
Published: June 2024

Abstract

Background: Eave spaces are major entry points through which malaria vectors enter houses. Interventions that target mosquitoes at the eaves have recently been developed. However, most of these interventions are based on insecticides for which resistance has been reported. Here we evaluated the efficacy of mosquito electrocuting eave tubes (MEETs) against Anopheles gambiae s.s. and An. funestus under semi-field conditions.
Methods: Experiments were conducted in two semi-field chambers each containing one experimental hut. Six electrocuting eave tubes were installed in each hut, to assess their impact on laboratory-reared Anopheles gambiae s.s. and An. funestus. Each species was assessed separately over ten nights by releasing 200 unfed females per night into each chamber. One volunteer slept in each hut from 7 pm to 5 am. Mosquitoes were collected indoors and outdoors using mouth and prokopack aspirators.
Results: MEETs significantly reduced the nightly An. gambiae s.s. indoor and outdoor biting, by 21.1% and 37.4%, respectively. Indoor biting An. funestus were reduced by 87.5% while outdoor biting numbers of An. funestus declined by 10.4%.
Conclusions: MEETs pose a promising tool for controlling mosquitoes at the point of house entry. Further validation of its potential under natural field conditions is necessary. Several advantages over insecticide-based eave tubes are foreseen and discussed in this article.
Analyzing Interactions in Donation-Based Live Streaming Platforms: A Multi-Leader-Follower Game Approach
Authors: Fargetta Georgia , Ortis Alessandro , Battiato Sebastiano , Scrimali Laura Rosa Maria 
Published: June 2024

Abstract

This paper investigates the interactions between content creators and viewersin donation-based live streaming platforms. In these social media systems,creators produce their content, while viewers enjoy the live streaming and decide to donate money to creators, making decisions to contribute financial support to the creators. To capture the sequential decisionprocess of the model, we introduce a multi-leader-follower game, inwhich creators act as the leaders of the game and viewers as the followers. Creators first optimize their performance level and the duration of the streams to maximize their profit. Then, viewers optimize the time spent watching a live stream to maximize their utility. Thus, the first stage of the game models thenon-cooperative competition among creators, while the second stage represents the behaviour of viewers deciding on their content demands.We formulate these stages as Nash equilibrium problems, and then as variational inequalities. We analyze the existence and uniqueness of the Stackelberg equilibrium. Then, we derive a supervised learning algorithm to estimate the parameters of the Artificial Neural Network model, focused on the advertisement function to properly verify the proposed model in a realistic setting.
HSP90 provides plasticity to plant development by gradually stabilizing plasma membrane presence of ABCB-type auxin transporters
Authors: Geisler Markus , Tsering Tashi , Donato Martin Di , Samakovli Despina , Milioni Dimitra , Azarello Elisa , Mancuso Stefano , Pukyšová Vendula , Zwiewka Marta , Nodzynski Tomasz , Stumpe Michael , Ludwig-Müller Jutta , Bailly Aurelien , Hatzopoulos Polydefkis 
Published: June 2024

Abstract

Closely related FKBP orthologs, FKBP42/TWISTED DWARF1 (TWD1) and FKBP38, have been shown to control the biogenesis of plant and mammalian ATP-binding cassette (ABC) transporters, respectively. However, the mechanistic role of described FKBP-ABCB interaction is widely unknown.
Here, we verify cytosolic HEAT-SHOCK PROTEIN90 (HSP90) isoforms as valid interactors of TWD1 and map HSP90 binding to an amphiphilic alpha-helix preceding its TPR domain. We provide pharmacological and genetic evidence that a subset of TWD1-interacting ABCBs, in contrast to mammalian ABCBs, are constitutive HSP90 clients in plants. This effect and its specificity are presumably provided by TWD1. Our data strongly correlate the effect of HSP90 inhibition on ABCB-mediated development and ABCB plasma membrane stability on the one hand and ABCB cycling rate on the other
Our results uncover a dynamic mechanism of HSP90 for gradual stabilization of the plasma membrane ABCB isoforms to regulate polar auxin transport and to confer developmental plasticity.
Improvement in growth performance, digestive enzymes activity, immune-related gene expression, and resistance against Edwardsiella tarda ETS1.1 in African catfish (Clarias sp.) with dietary supplementation of euryhaline probiotic and paraprobiotic Bacillus cereus BR2
Authors: YUHANA MUNTI , ASVIA SAUFA , AFIFF USAMAH , WIDANARNI WIDANARNI 
Published: June 2024

Abstract

The use of probiotics has become an alternative in the aquaculture industry and is considered a new tool for disease control. However, the maintenance of viability of probiotic bacterial cells during storage is quite challenging. This study aimed to investigate the potential effects of euryhaline probiotic and paraprobiotic B. cereus BR2 on African catfish, specifically on growth performance, gastrointestinal health, immune-related gene expression, and resistance to E. tarda ETS1.1. The test feed was enriched with a 1% (w/w) dose of probiotics and paraprobiotics at a cells density of 108 and 1010 CFU mL− 1, each with replications. For diet supplementation experiment, African catfish fry with initial average body weight of 6.67 ± 0.34 g were randomly placed into six aquaria containing 60 L volume of freshwater and reared for 30 days. Afterwards, fish were challenged intraperitoneally on day 31− th with E. tarda ETS1.1 at cell density of 107 CFU mL− 1, and reared for 14 days. The results showed that diets treated with probiotics and paraprobiotics 108 and 1010 CFU mL− 1 significantly (p < 0.05) increased mean final weight, mean final biomass, specific growth rate (SGR), disease resistance (survival rate) and reduced feed conversion ratio (FCR) values. Digestive enzyme (amylase, protease, lipase) activities, total bacterial population and abundance of B. cereus BR2 in the intestine were measured higher in supplementation treatments than control fish. After the challenge test, decreased E. tarda ETS1.1 abundance in kidney and liver of fish were measured in both probiotic and paraprobiotic treatments. Furthermore, interleukin 1β (IL-1β) gene expression showed upregulation in fish after treatment. Similarly, major histocompatibility complex 2β (MHC-2β) expression was significantly upregulated after supplementation and post-challenge, with the highest level of MHC-2β mRNA expression found in DPI 7. The supplementation of probiotic and paraprobiotic B. cereus BR2 per oral effectively improved growth performance, digestive enzymes activity, immune-related gene expression, resistance of African catfish to E. tarda ETS1.1.
Lightweight Ship Target Detection based on CA-Yolov5
Authors: Wu Xia 
Published: June 2024

Abstract

The models of existing ship target detection algorithms are large and not suitable for deployment at the edge devices, therefore, a lightweight ship target detection algorithm named CA-Yolov5 based on coordinate attention mechanism is proposed. Firstly, CA-Yolov5 takes YOLOv5s as the baseline and replaces the backbone with ShuffleNet v2 which effectively reduces the number of parameters and the amount of calculation. Secondly, the coordinate attention module is introduced to improve the cross-channel positioning ability of the model. Finally, the experimental results on the Seaships dataset show that compared with YOLOv5s, the size of the CA-Yolov5 model is reduced by 90.8% to only 1.3M, and the accuracy can reach 96.9%, which is only 0.2%. CA-Yolov5 is small and accurate, making it more suitable and feasible for deployment on mobile and edge devices.
Influence of Carbon ionization increment by adding Ne on the Bonding, Electrical, and Tribological properties of Carbon Thin Films deposited by HiPIMS
Authors: Tello Cesar D. Rivera , Ruiz Francisco Javier Flores , Alvarez Jonathan Perez , Guerrero Jesus Alonso , Farías Ivan , Cova Luis Flores , Flores Martín 
Published: June 2024

Abstract

In this work, we use mass quadrupole spectroscopy to analyze the ion energy distribution function for C+ ions from different gas composition discharges (20, 40, 60, 80, and 90% Ne) + Ar in a plasma sputtering process. Carbon films were obtained for each gas composition discharge. The carbon bonding structure of films was analyzed by Raman spectroscopy using deconvolution fitting of the G and D Raman peaks. The C-sp3 content was correlated with the electrical and tribological properties of the carbon films. Our results provide further corroboration for High Power Impulse Magnetron Sputtering or HiPIMS processes of the enhancement of carbon ionization by adding neon in conventional argon gas during the deposition process. Furthermore, we found that excessive levels of carbon ionization were detrimental in the formation of C-sp3 decreasing the resistivity, elastic modulus, and hardness of the samples. In addition, the use of neon in the gas working mixture increased the deposition rate significantly compared to argon-only processes. Tribology showed that an intermediate C-sp3 content in the carbon films developed desirable tribological behaviors with lower friction coefficients and wear rates, revealing that higher values of C-sp3 content are not necessarily for robust solid lubricious and wear resistance.
Active Oxidative Metabolism and Impaired Glyoxalase System Under Increased Intracellular Oxidative Stress in Non-Small Cell Lung Cancer
Authors: Birner-Gruenberger Ruth , Tomin Tamara , Honeder Sophie , Liesinger Laura , Gremel Daniela , Retzl Bermhard , Lindenmann Joerg , Brcic Luka , Schittmayer Matthias 
Published: June 2024

Abstract

Reactive oxygen species can oxidatively modify enzymes to reroute metabolic pathways according to tumor needs but we lack overview of all potential targets. Thiol groups are most susceptible to oxidative modifications but rarely analyzed in clinical settings due to their reactivity. To accurately address the cross-talk between redox signaling and metabolism we collected tumor and healthy tissue from 70 individuals with non-small cell lung cancer right after surgery into a thiol-quenching solution, then carried out redox-proteomics. As a result of such an unbiased approach, we for the first time show evidence of higher oxidation of a number of key metabolic enzymes in tumor (especially glucose-related); we demonstrate that cancer strives to maintain oxidative metabolism amid the rise of intracellular oxidative stress; and report both redox and protein level deactivation of the glyoxalase system, which might be compensated by higher excretion or lower production of toxic methylglyoxal, aiding cancer progression.
Research on Intelligent Multimodal Gesture-Guided Control of Robotic Arms
Authors: Xu Shizhou , Zhang Mengjie , Lu Chenshuo 
Published: June 2024

Abstract

With the continuous advancement of industrial intelligence, robotic arms have become essential tools for sorting materials and addressing safety hazards in work environments. Traditional robotic arm control technologies, while playing a significant role in high-risk environments such as factories, nuclear power plants, and toxic substance handling sites, are limited by the complexity of their operation and programming, as well as the high cost of wearable equipment. This research proposes a multimodal robotic arm control scheme that does not require the use of wearable sensors, enhancing the operational flexibility and safety of robotic arms in tasks such as material sorting, quality inspection, and hazard elimination. The proposed scheme captures hand gestures through computer vision technology and utilizes artificial intelligence to parse natural language commands, ultimately integrating multimodal signals to achieve precise control of the robotic arm. Experimental results demonstrate that the proposed control scheme can accurately map hand gestures to the robotic arm's coordinate system, efficiently performing sorting and hazard elimination tasks without the need for any wearable sensor devices. This approach has the potential to drive the manufacturing industry towards greater efficiency and intelligence.
Dexamethasone and IFN-γ primed mesenchymal stem cells conditioned media immunomodulates aberrant NETosis in SLE via PGE2 and IDO
Authors: Priya Khushbu , Thacker Hiral , Chaubey Manaswi , Rai Madhukar , Singh Shambhavi , Rawat Sonali , Giri Kiran , Mohanty Sujata , Rai Geeta 
Published: June 2024

Abstract

Background
Systemic Lupus Erythematosus (SLE) is characterized by dysregulated immune responses, with neutrophil extracellular traps (NETs) playing a significant role. NETs are recognized by autoantibodies in SLE patients, exacerbating pathology. Both excessive NET formation and impaired degradation contribute to SLE pathophysiology.
Objective
To investigate the immunomodulatory effects of DW and IW on NETosis and associated protein markers in SLE patients’ LPS or ribonucleoprotein immune complexes (RNP ICs) induced neutrophils and in pristane induced lupus (PIL) model. And to elucidate the mechanism involved therein.
Methods
We investigated the immunomodulatory effects of DW and IW on NETosis in SLE. Utilizing in vitro and in vivo models, we assessed the impact of preconditioned media on NET formation and associated protein markers neutrophil elastase (NE), citrullinated histone (citH3), myeloperoxidase (MPO), cytoplasmic and mitochondrial ROS production. We also examined the involvement of key immunomodulatory factors present in DW and IW, including prostaglandin E2 (PGE2), indoleamine 2,3-dioxygenase (IDO), and transforming growth factor-beta (TGF-β).
Results
Preconditioned media effectively suppressed NETosis and reduced ROS generation in SLE neutrophils, indicating their immunomodulatory potential. Inhibition studies implicated IDO and PGE2 in mediating this effect. Combined treatment with DW or IW together with hydroxychloroquine (HCQ) demonstrated superior efficacy over HCQ alone, a standard SLE medication. In PIL mouse model, DW and IW treatments reduced NETosis, ROS generation, as evidenced by decreased NET-associated protein expression in vital organs.
Conclusion
Our study highlights the multifaceted impact of IW and DW on NETosis, ROS dynamics, and lupus severity in SLE. These findings underscore the potential of preconditioned media for the development of targeted, personalized approaches for SLE treatment.
Human post-implantation blastocyst-like characteristics of Muse cells isolated from human umbilical cord
Authors: Kushida Yoshihiro , Oguma Yo , Abe Kana , Deguchi Taichi , Barbera Federico Girolamo , Nishimura Noriyuki , Fujioka Kazumichi , Iwatani Sota , Dezawa Mari 
Published: June 2024

Abstract

Muse cells, identified as cells positive for the pluripotent surface marker SSEA-3, are pluripotent-like endogenous stem cells located in the bone marrow (BM), peripheral blood, and organ connective tissues. The detailed characteristics of SSEA-3(+) cells in extraembryonic tissue, however, are unknown. Here, we demonstrated that similar to human-adult tissue-Muse cells collected from the BM, adipose tissue, and dermis as SSEA-3(+), human-umbilical cord (UC)-SSEA-3(+) cells express pluripotency markers, differentiate into triploblastic-lineage cells at a single cell level, migrate to damaged tissue, and exhibit low telomerase activity and non-tumorigenicity. Notably, ~ 20% of human-UC-SSEA-3(+) cells were negative for X-inactive specific transcript (XIST), a naïve pluripotent stem cell characteristic, whereas all human adult tissue-Muse cells are XIST-positive. Single-cell RNA sequencing revealed that the gene expression profile of human-UC-SSEA-3(+) cells was more similar to that of human post-implantation blastocysts than human-adult tissue-Muse cells. The DNA methylation level showed the same trend, and notably, the methylation levels in genes particularly related to differentiation were lower in human-UC-SSEA-3(+) cells than in human-adult tissue-Muse cells. Furthermore, human-UC-SSEA-3(+) cells newly express markers specific to extraembryonic-, germline-, and hematopoietic-lineages after differentiation induction in vitro whereas human-adult tissue-Muse cells respond only partially to the induction. Among various stem/progenitor cells in living bodies, those that exhibit properties similar to post-implantation blastocysts in a naïve state have not yet been found in humans. Easily accessible human-UC-SSEA-3(+) cells may be a valuable tool for studying early-stage human development and human reproductive medicine.
Catechin, Epicatechin and Quercetin against Gamma-irradiation- induced Nrf-2, Nf-kB and Antioxidant Enzymes alterations in Cellular System of Rats
Authors: BELLO Olamilekan Kabir , Salawu Musa Oyewole , Samuel Joseph Asuku , Henrietta Omotayo , Samiatu LUKMAN 
Published: June 2024

Abstract

Background: Cell are prone to oxidative insults that are mediated by Rats exposure to gamma (γ) irradiation. These insult are nuclear factor kappa-B (Nf-kB) mediated, but the activation of nuclear related factor-2 (Nrf-2) renders cells resistant to oxidative insult and inflammatory challenges, mediated by Nf-kB. Plant materials have been used successfully to restore cellular alterations mediated by Nf-kB. Contain in these plants are catechin, epicatechin, astragalin and quercetin. Hence this study investigated the effects of catechin, epicatechin and quercetin against γ-irradiation-induced Nrf-2, Nf-kB and antioxidant enzymes alterations in Rats.
Materials and Method: A total of thirty (30) rats (200 ± 5g) were distributed into 5 groups of 6 each. Except group 1, all other groups were exposed to 6 grey γ-irradiation. Group 2 were fed with rat chow and water only such that groups 3, 4 and 5 were administered catechin (CAT), epicatechin (EPC) and quercetin (QCT) at 40 mg/kg body weight respectively. The rats were sacrificed and biochemical parameters were assayed. Data were analyzed using SPSS.
Results:Irradiation significantly (p<0.05) increased Nf-kB, reduced antioxidant enzymes activities, with a significant (p<0.05) decreased in Nrf-2 concentration of irradiated rats. Administration of CAT, EPC and QCT significantly (p<0.05) decreased Nf-kB and a corresponding significant (p<0.05) increased in Nrf-2 concentration and antioxidant enzymes activities of administered groups when compared with control.
Conclusion: CAT, EPC and QCT have restored cellular alterations caused by γ-irradiation, hence can be used as protection against irradiation-induced alterations.
A prognostic matrix gene expression signature defines functional glioblastoma phenotypes and niches
Authors: Vishnoi Monika , Dereli Zeynep , Yin Zheng , Kong Elisabeth K. , Kinali Meric , Thapa Kisan , Babur Ozgun , Yun Kyuson , Abdelfattah Nourhan , Li Xubin , Bozorgui Behnaz , Farach-Carson Mary C. , Rostomily Robert C. , Korkut Anil 
Published: June 2024

Abstract

Background. Interactions among tumor, immune, and vascular niches play major roles in driving glioblastoma (GBM) malignancy and treatment responses. The composition, heterogeneity, and localization of extracellular core matrix proteins (CMPs) that mediate such interactions, however, are not well understood.
Methods. Here, through computational genomics and proteomics approaches, we analyzed the functional and clinical relevance of CMP expression in GBM at bulk, single cell, and spatial anatomical resolution.
Results. We identified genes encoding CMPs whose expression levels categorize GBM tumors into CMP expression-high (M-H) and CMP expression-low (M-L) groups. CMP enrichment is associated with worse patient survival, specific driver oncogenic alterations, mesenchymal state, infiltration of pro-tumor immune cells, and immune checkpoint gene expression. Anatomical and single-cell transcriptome analyses indicate that matrisome gene expression is enriched in vascular and leading edge/infiltrative niches that are known to harbor glioma stem cells driving GBM progression. Finally, we identified a 17-gene CMP expression signature, termed Matrisome 17 (M17) signature that further refines the prognostic value of CMP genes. The M17 signature is a significantly stronger prognostic factor compared to MGMT promoter methylation status as well as canonical subtypes, and importantly, potentially predicts responses to PD1 blockade.
Conclusion. The matrisome gene expression signature provides a robust stratification of GBM patients by survival and potential biomarkers of functionally relevant GBM niches that can mediate mesenchymal-immune cross talk. Patient stratification based on matrisome profiles can contribute to selection and optimization of treatment strategies.
ZIF-8-on-MIL-68(Ga) Derived S-scheme Heterojunction for Photocatalytic Reduction CO2 to CH4 in Pure Water
Authors: Hu Juncheng 
Published: June 2024

Abstract

ZnGa2O4 possess the potential for simultaneously reduction CO2 and oxide water with photogenerated electrons and holes, however, pure ZnGa2O4 suffers from wide bandgap and sluggish migration kinetics of charge carriers. In this work, the MOF-on-MOF precursors of ZIF-8-on-MIL-68(Ga) were first synthesized and in situ converted into the ZnGa2O4/ZnO heterostructure. After loading of Au cocatalyst, the ternary Au/ZnGa2O4/ZnO photocatalyst could reduce CO2 into CH4 in pure water without any sacrificial reagent, reaching a CH4 yield of 21.1 umol g-1 h-1 as well as high selectivity of 93.8%. The unique MOF-on-MOF derived hollow structure provides large specific surface area, abundant heterogeneous interfaces as well as increases the light harvesting ability. Moreover, experimental results and DFT calculation reveal that the S-scheme heterojunction deriving from ZIF-8-on-MIL-68(Ga) could efficiently promote charge separation and enable strong photoredox ability while the decoration of Au cocatalyst could further lower the Gibbs free energy barriers for the rate-determining step, thereby leading to CH4 production with high activity and selectivity. This study verified the strategy of converting MOF-on-MOF composites into S-scheme heterostructures was feasible, which could be extended to other MOF-on-MOF precursors to exploit the synergistic effects between different photocatalysis.