bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidence for the Credibility of Health Economic Models for Health Policy Decisionmaking: A Systematic Literature Review of Screening for Abdominal Aortic Aneurysms
Authors: SØGaard Rikke , Lindholt Jes 
Published: September 2011

Objective To investigate whether the credibility of health economic models of screening for abdominal aortic aneurysms for health policy decisionmaking has improved since 2005 when a systematic review by Campbell et al. concluded that reporting standards were poor and there was divergence between the findings of studies that was hard to explain. Methods A systematic literature review was carried out following PRISMA reporting principles. Health economic models of the cost-effectiveness of screening for abdominal aortic aneurysms published between 2005-2010 were included. Key characteristics were extracted and the models were assessed for quality against guidelines for best practice by a multidisciplinary team. Results Seven models were identified and found to provide divergent guidance. Only three reports met 10 of the 15 quality criteria. Conclusions Researchers in the field seem to have benefited from general advances in health economic modelling and some improvements in reporting were noted. However, the low level of agreement between studies in model structures and assumptions, and difficulty in justifying these (convergent validity), remain a threat to the credibility of health economic models. Decision-makers should not accept the results of a modelling study if the methods are not fully transparent and justified. Modellers should, whenever relevant, supplement a primary report of results with a technical report detailing and discussing the methodological choices made.
Convenient way of synthesis and crystal structure of 1-[(5-chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine, a histamine H4 receptor antagonist
Authors: Łażewska Dorota , Karolak-Wojciechowska Janina , Kolesińska Beata , Kamiński Zbigniew , Kieć-Kononowicz Katarzyna 
Published: September 2011

Abstract
1-[(5-Chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine (JNJ 7777120) is the known histamine H4 receptor reference compound. The convenient way of its synthesis and the crystal structure are described.
Recycled Asphalt Shingles Mixed with Granular Byproducts as Structural Fills
Authors: Soleimanbeigi Ali , Edil Tuncer B. , Benson Craig H. 
Published: September 2011

Abstract
In this study, recycled asphalt shingles (RAS) were evaluated for potential use as structural fill in highway embankments or backfills behind retaining walls. Bottom ash (BA) and foundry slag (FS) were also investigated as additives to RAS to enhance its mechanical properties. The engineering properties of RAS:BA/FS mixtures including compaction characteristics, hydraulic conductivity, compressibility, shear strength, and the coefficient of lateral earth pressure at rest were evaluated in a systematic manner. The results show that the addition of bottom ash and foundry slag significantly reduces the compressibility of RAS while increasing the drainage capacity and shear strength. The RAS:BA/FS mixtures are a favorable light weight material for use as embankment fills or backfill behind retaining walls.
Complete Oral Rehabilitation of a Postresection Ameloblastoma Patient: A Clinical Case Report
Authors: Minichetti John C. , D'Amore Joseph C. , Schwarz Evan 
Published: September 2011

Conventional ameloblastomas are rare, benign, epithelial odontogenic tumors that tend to grow slowly in the mandible or maxilla, but are locally invasive and can be highly destructive of the surrounding dental anatomy. Aggressive resection is the most effective method of eliminating the tumors, but treatment can further contribute to patient deformity and malfunction. Ameloblastomas also have a high rate of recurrence, which significantly diminishes 8 years after resection, but still requires vigilant clinical monitoring. This case report describes the complete oral rehabilitation of a postresection ameloblastoma patient with a mandibular reconstruction plate and partial edentulism. An autogenous graft was taken from the patient's iliac crest, shaped to fit the defect, and attached with bone screws. After graft incorporation, dental implants were successfully placed into the augmented ridge and restored with a fixed partial denture. There was no evidence of tumor recurrence during the 10 months of treatment or 8 years of subsequent clinical monitoring.
Effect of Cytochrome P450 3A5 Genotype on Atorvastatin Pharmacokinetics and Its Interaction with Clarithromycin
Authors: Shin Jaekyu , Pauly Daniel F. , Pacanowski Michael A. , Langaee Taimour , Frye Reginald F. , Johnson Julie A. 
Published: September 2011

Study Objective. To assess the effects of the cytochrome P450 (CYP) 3A genotype, CYP3A5, on atorvastatin pharmacokinetics and its interaction with clarithromycin.Design. Prospective, two‐phase, randomized‐sequence, open‐label pharmacokinetic study.Setting. Clinical research center at a teaching hospital.Subjects. Twenty‐three healthy volunteers who were screened for genotype: 10 subjects carried the CYP3A5*1 allele (expressors) and 13 subjects did not (nonexpressors).Intervention. In one phase, subjects received a single oral dose of atorvastatin 20 mg. In the other phase, subjects received clarithromycin 500 mg twice/day for 5 days; on day 4 after the morning dose, subjects also received a single oral dose of atorvastatin 20 mg. All subjects participated in both phases of the study, which were separated by at least 14 days.Measurements and Main Results. Pharmacokinetic parameters of both forms of atorvastatin—atorvastatin acid and atorvastatin lactone—were compared between CYP3A5 expressors and nonexpressors, both in the absence and presence of clarithromycin, a strong CYP3A inhibitor. The acid form is pharmacologically active, and the lactone form has been associated with the atorvastatin's muscle‐related adverse effects. Atorvastatin acid exposure did not differ significantly between CYP3A5 genotype groups. When subjects had not received clarithromycin pretreatment, the area under the concentration‐time curve from time zero extrapolated to infinity (AUC0‐∞) of atorvastatin lactone was 36% higher in nonexpressors than in expressors (median 47.6 ng•hr/ml [interquartile range (IQR) 37.8–64.3 ng•hr/ml] vs 34.9 ng•hr/ml [IQR 21.6–42.2 ng•hr/ml], p=0.038). After clarithromycin pretreatment, changes in the pharmacokinetic parameters of atorvastatin acid and lactone were not significantly different between the nonexpressors versus the expressors; however, the increase in the AUC0‐∞ of atorvastatin lactone was 37% greater in expressors than in nonexpressors (geometric mean ± SD 3.59 ± 0.57 vs 2.62 ± 0.35, p=0.049).Conclusion. Our data suggest that the CYP3A5 genotype has minimal effects on the pharmacokinetic parameters of atorvastatin and its interaction with clarithromycin; these effects are unlikely to be clinically significant.
Optimizing Insulin Glargine Plus One Injection of Insulin Glulisine in Type 2 Diabetes in the ELEONOR Study
Authors: Nicolucci Antonio , Del Prato Stefano , Vespasiani Giacomo ,   on behalf of the ELEONOR Study Group
Published: September 2011

OBJECTIVE
To determine the functional health status and treatment satisfaction in patients with type 2 diabetes from the Evaluation of Lantus Effect ON Optimization of use of single dose Rapid insulin (ELEONOR) study that investigated whether a telecare program helps optimization of basal insulin glargine with one bolus injection of insulin glulisine.

RESEARCH DESIGN AND METHODS
Functional health status and treatment satisfaction were investigated using the 36-Item Short-Form (SF-36) Health Survey, the World Health Organization Well-Being Questionnaire (WBQ), and the Diabetes Treatment Satisfaction Questionnaire.

RESULTS
Of 291 randomized patients, 238 completed the study (telecare: 114; self-monitoring blood glucose: 124). Significant improvements were detected in most SF-36 domains, in WBQ depression and anxiety scores, and in treatment satisfaction, without differences between study groups.

CONCLUSIONS
An insulin regimen that substantially improves metabolic control, while minimizing the risk of hypoglycemia, can positively affect physical and psychologic well-being and treatment satisfaction irrespective of the educational support system used.
Population Pharmacokinetics of Lopinavir and Ritonavir in Combination with Rifampicin-Based Antitubercular Treatment in HIV-Infected Children
Authors: Zhang Chao , McIlleron Helen , Ren Yuan , van der Walt Jan-Stefan , Karlsson Mats O , Simonsson Ulrika SH , Denti Paolo 
Published: September 2011

Background The preferred antiretroviral regimen for young children previously exposed to non-nucleoside reverse transcriptase inhibitors is lopinavir/ ritonavir plus two nucleoside reverse transcriptase inhibitors. Rifampicin-based antitubercular treatment reduces lopinavir concentrations. Adding extra ritonavir to lopinavir/ ritonavir overcomes the effect of rifampicin, however this approach is not feasible in many settings. Methods We developed an integrated population model describing lopinavir and ritonavir pharmacokinetics to predict lopinavir/ritonavir (4:1) doses achieving target lopinavir exposures in children treated for tuberculosis. The model included data from 15 children given ‘super-boosted’ lopinavir (lopinavir/ritonavir = 1:1) and 20 children given twice the standard dose of lopinavir/ritonavir every 12 h during antitubercular treatment, and from children given standard lopinavir/ritonavir doses every 12 h (39 without tuberculosis and 11 sampled again after antitubercular treatment). Results A one-compartment model with first- order absorption and elimination best described the pharmacokinetics of lopinavir and a one-compartment model with transit absorption compartments described ritonavir pharmacokinetics. The dynamic influence of ritonavir concentration on lopinavir oral clearance was modelled as direct inhibition with an Emax model. Antitubercular treatment reduced the oral bioavailability of lopinavir by 77% in children receiving twice usual lopinavir/ritonavir doses and increased ritonavir clearance by 50%. Simulations predicted that respective 27, 21, 20 and 18 mg/kg 8-hourly doses of lopinavir (in lopinavir/ritonavir, 4:1) maintains lopinavir concentrations >1 mg/l in at least 95% of children weighing 3–5.9, 6–9.9, 10–13.9 and 14–19.9 kg. Conclusions The model describing the interactions between lopinavir, ritonavir and rifampicin in young children predicted feasible 8-hourly doses of lopinavir/ ritonavir resulting in therapeutic lopinavir concentrations during antitubercular treatment.
Une lecture de la révolution tunisienne
Authors: Dakhli Leyla 
Published: September 2011

Résumé Issue d’une observation sur le vif des événements qui se sont déroulés en Tunisie du 17 décembre 2010 à la fin mai 2011, cette chronique sur la « révolution tunisienne » propose quelques pistes de réflexion et ouvre sur des questions qui se posent pour l’historien, en particulier face à la profusion de sources numériques et face à l’étude de réseaux de contestation et de mobilisation à travers les outils du web 2.0.
Le développement de l'équitation de loisir dans les territoires ruraux : entre influences sectorielles et périurbanisation
Authors: Vial Céline , Aubert Magali , Perrier-Cornet Philippe 
Published: September 2011

Le développement des loisirs équestres en France est en grande partie porté par des particuliers, propriétaires de leur(s) équidé(s). Cet article étudie les facteurs susceptibles de rendre compte de la plus ou moins grande importance de ces équidés dans les espaces ruraux et périurbains. Les résultats mettent en évidence des influences réciproques entre la densité d’équidés et l’intensité du développement résidentiel de ces territoires. Des effets sectoriels sont également testés : l’influence du secteur agricole est complexe, relevant à la fois de concurrences et complémentarités pour l’occupation de l’espace. On constate en revanche un effet très net d’entraînement local de la dynamique professionnelle équestre sur la présence de ces équidés. Finalement, ce travail, en mettant l’accent sur l’imbrication entre le développement des loisirs équestres et les transformations actuelles des campagnes, présente les équidés de ces propriétaires amateurs comme de bons révélateurs et marqueurs des nouvelles dynamiques rurales.
Long-term Results of Arthroscopic Labral Debridement: Predictors of Outcomes
Authors: Meftah Morteza , Rodriguez Jose A. , Panagopoulos Georgia , Alexiades Michael M. 
Published: September 2011

Limited data exist regarding the long-term results of labral debridement and the effect of coexisting pathology on outcomes. Our hypothesis was that untreated coexisting hip pathologies such as femoroacetabular impingement and arthritis significantly affect the outcomes of arthroscopic labral debridement.
Between 1996 and 2003, fifty consecutive patients who underwent hip arthroscopy and labral debridement with a mean follow-up of 8.4 years were included in our study. Patients’ preoperative Harris Hip Scores and coexisting pathologies such as femoroacetabular impingement, dysplasia, or arthritis were recorded as variables. Postoperative Harris Hip Score and satisfaction at final follow-up were recorded as outcomes. Good or excellent results were achieved in 62% of cases (58% in patients with untreated femoroacetabular impingement and 19% in patients with arthritis). Failures included 2 cases that were converted to total hip replacement (4.5 and 5.2 years after index procedure) due to advancement of arthritis and 1 case of repeat arthroscopy for cam decompression. Patients with no coexisting pathology had significantly higher satisfaction and Harris Hip Scores. Almost all of the patients with low postoperative Harris Hip Scores had arthritic changes. Arthritis had a significant correlation with low postoperative Harris Hip Scores and satisfaction.
Coexisting pathology, especially arthritis and untreated femoroacetabular impingement, can result in inferior outcomes. Arthroscopic labral debridement of symptomatic tears in selected patients with no coexisting pathology can result in favorable long-term results. Arthritis is the strongest independent predictor of poor outcomes.
Use of a Rugby Helmet Brace for Postoperative Treatment of Muscular Torticollis
Authors: Yamada Naotake , Kim Wook-Cheol , Hosokawa Motoo , Yoshida Takashi , Mouri Hisashi , Oka Yoshinobu , Kotoura Yoshihiro , Nakase Masashi , Nishida Atsushi , Kusakabe Torao , Kubo Toshikazu 
Published: September 2011

Prior to 1992, our postoperative management for congenital muscular torticollis consisted of either plaster cast immobilization or no immobilization, depending on the patient’s age and the degree of contracture. However, some patients required further surgery and developed complications. In 1992, we produced rugby helmet braces for postoperative management. The purpose of this study was to compare the clinical results of the previous postoperative management with the results achieved using rugby helmet braces.
Twenty-five children aged younger than 6 years underwent caudal partial resection of the sternocleidomastoid muscle. Twelve children aged 6 years and older underwent cranial tenotomy. These 37 patients were divided into 2 groups: no immobilization or plaster immobilization (group A; n=19) and rugby helmet braces (group B; n=18). Canale’s method was used for evaluation of clinical results. In group A, the results were good in 12 patients, fair in 4, and poor in 3, whereas all 18 patients in group B had good results. Two patients in group A required further surgery, and complications were observed in 5 patients. In group B, alopecia areata was observed in 1 patient.
The rugby helmet brace is easy to put on and remove, providing good retention and allowing for physiotherapy. It provides a useful method of postoperative management for congenital muscular torticollis.
Preferred Use of Polyhexanide in Orthopedic Surgery
Authors: Röhner Eric , Seeger Jörn B. , Hoff Paula , Pfitzner Tilman , Preininger Bernd , Andreas Kristin , Buttgereit Frank , Perka Carsten , Matziolis Georg 
Published: September 2011

In orthopedic and trauma surgery, the most frequently used antiseptic is polyhexanide. Its favored application is based on prepossessing tissue compatibility in contrast to various antiseptics and a high antimicrobiological effect. Recent studies showed toxic effects of this antiseptic on human chondrocytes. The aim of this study was to further analyze the toxic and apoptotic effects of polyhexanide on primary human chondrocytes. The hypothesis of this study was that polyhexanide induces apoptosis on human chondrocytes.
Primary human chondrocytes were isolated and cultured from human donors with osteoarthritis of the knee who underwent total arthroplasty and had no indication of infection. Polyhexanide at a standard concentration of 0.04% was added to the monolayer cultures. Early and late apoptotic cells were analyzed by flow cytometric detection of annexin V, active caspases, and 7AAD, and by fluorescence microscopy using annexin V and propidium iodide staining. Flow cytometric analysis demonstrated an increase of annexin V and active caspases expression of human chondrocytes after incubation with polyhexanide. Fluorescence microscopy demonstrated a high number of annexin V positive and propidium iodide negative early apoptotic cells. The data show that polyhexanide promotes apoptosis on primary human chondrocytes in vitro, which may indicate the use of polyhexanide in septic joint surgery.
Uniquely D-colourable Digraphs with Large Girth
Authors: Harutyunyan Ararat , Kayll P. Mark , Mohar Bojan , Rafferty Liam 
Published: September 2011

Abstract Let C and D be digraphs. A mapping f : V(D) →V(C) is a C-colouring if for every arc uv of D, either f (u) f (v) is an arc of C or f (u) = f (v), and the preimage of every vertex of C induces an acyclic subdigraph in D. We say that D is C-colourable if it admits a C-colouring and that D is uniquely C-colourable if it is surjectively C-colourable and any two C-colourings of D differ by an automorphism of C. We prove that if a digraph D is not C-colourable, then there exist digraphs of arbitrarily large girth that are D-colourable but not C-colourable. Moreover, for every digraph D that is uniquely D-colourable, there exists a uniquely D-colourable digraph of arbitrarily large girth. In particular, this implies that for every rational number r ≥ 1, there are uniquely circularly r-colourable digraphs with arbitrarily large girth.
Effect of a Laboratory Result Pager on Provider Behavior in a Neonatal Intensive Care Unit
Authors: Stavroudis TA. , Miller RE. , Lehmann HP. , Lehmann CU. , Samal L. 
Published: September 2011

SummaryBackground: A computerized laboratory result paging system (LRPS) that alerts providers about abnormal results (“push”) may improve upon active laboratory result review (“pull”). However, implementing such a system in the intensive care setting may be hindered by low signal-to-noise ratio, which may lead to alert fatigue.Objective: To evaluate the impact of an LRPS in a Neonatal Intensive Care Unit.Methods: Utilizing paper chart review, we tallied provider orders following an abnormal laboratory result before and after implementation of an LRPS. Orders were compared with a predefined set of appropriate orders for such an abnormal result. The likelihood of a provider response in the post-implementation period as compared to the pre-implementation period was analyzed using logistic regression. The provider responses were analyzed using logistic regression to control for potential confounders.Results: The likelihood of a provider response to an abnormal laboratory result did not change significantly after implementation of an LRPS. (Odds Ratio 0.90, 95% CI 0.63–1.30, p-value 0.58) However, when providers did respond to an alert, the type of response was different. The proportion of repeat laboratory tests increased. (26/378 vs. 7/278, p-value = 0.02)Conclusion: Although the laboratory result pager altered healthcare provider behavior in the Neonatal Intensive Care Unit, it did not increase the overall likelihood of provider response.
Urinary Peptides and Calcium Oxalate Nephrolithiasis, A Combined Approach: MALDI-TOF Mass Spectrometry and MicroBCA Protein Assay
Authors: Vittori Matteo , D'addessi Alessandro , Sacco Emilio , Inzitari Rosanna , Fanali Chiara , Totaro Angelo , Bassi Pierfrancesco 
Published: September 2011

Background Urinary lithiasis is one of the most common benign urological diseases. There is growing evidence that a delicate equilibrium regulated by the function of proteins, soluble peptides, membrane proteins and intracellular mechanisms actually exists. We have studied the urinary protein composition of patients affected by calcium oxalate nephrolithiasis in order to discover a biomarker or any predisposing factors. Methods The urinary protein composition of 17 patients (11 males, 6 females; mean age 45yrs ± 14SD), affected by calcium oxalate nephrolithiasis, was assessed in comparison with 17 healthy subjects. A qualitative assay was performed using MALDI-TOF mass spectrometry in a spectrum between 1 and 5kDa (medium size peptides), and a numerical (quantitative) assay using specific filters and MicroBCA Protein Assay Results No differences were detected in the mass spectrums between patients and control subjects: all peaks overlapped perfectly. The results of the numerical assay suggest that concentrations of protein species <5kDa in control samples were actually higher than those which were found in patients. The differences are statistically significant. Conclusions The study detected neither a biomarker nor any predisposing factors in “stone former” patients. The assessment of the results obtained, in terms of quantitative differences, indicate the need for further research.
Disrupting Sacred Time:
Authors: Schroeder Joy A. 
Published: September 2011

ABSTRACT
The Franciscan tertiary Angela of Foligno (ca. 1248–1309) reports that a demon tempted her with pride and desolation, falsely claiming to be the apostle Bartholomew and that it was his feast day. Other women (Christina of Stommeln, Gertrude of Helfta, and Catherine of Genoa) likewise received ominous visitations connected with Bartholomew. Angela’s experience reflects the influence of legends that associated Bartholomew with trickster demons. Her confusion about the date of Bartholomew’s festival may derive from a liturgical calendar error or disputes about the proper day for observing Bartholomew’s feast. The desolation caused by the Bartholomew impersonator foreshadows the intense interior struggles that occur later in Angela’s spiritual journey. This episode illustrates the importance of liturgical time. Disruption of Angela’s observance of a saint’s day brings about emotional suffering, while proper liturgical observance and attendance at mass have the power to restore her from demonic affliction and inspire profound spiritual experiences.