bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurophysiological assessment of the condition of the masticatory muscle group in patients with occlusion disorders and chronic generalized periodontitis
Authors: Domenyuk D. A. , Davydov B. N. , Kochkonyan T. S. , Kokareva A. V. , Glushanyan J. I. , Ivanyuta O. O. , Domenyuk S. D. 
Published: May 2024

Background. Recently, the interest of dentists and physiologists has been focused on the development of a set of informative computerized techniques for an objective analysis of the functional state of the dentofacial apparatus. Achieving certain successes in conducting functional diagnostic examinations contributes to the development of algorithms for complex treatment of patients with generalized periodontitis and premature occlusal contacts.Goal. Study of the functional state of the dentofacial apparatus according to the parameters of bioelectrical activity of muscles in patients with chronic generalized periodontitis and occlusal disorders in static and dynamic conditions of the lower jaw.Materials and methods. The study involved 37 people with clinically healthy periodontium, physiological occlusion, and absence of occlusal disorders (Group 1) and 45 patients with physiological types of occlusion, generalized chronic periodontitis and premature occlusal contacts (Group 2). Functional methods included electronic registration of occlusal relationships with the T-Scan® III computer occlusion analysis system and study of the bioelectrical activity of the masticatory muscles using the Bio-EMG® III electromyography using standard functional tests.Results. In patients of group 2, in comparison with patients of group 1, neuromuscular discoordination of the functional activity of the masticatory muscles was diagnosed. This condition is confirmed by the asymmetry and lack of muscle synergy when performing the “Maximum volitional compression” test, an improvement in the symmetry of the work of the muscles of the same name on the right and left sides and the synergy of the work of the muscles of the right and left masticatory groups, as well as a statistically significant increase in the values of biopotentials m. temporalis and m. masseter during the “Maximum volitional compression on rollers” test.Conclusions. Disturbances in the coordinated work of the muscles of the craniofacial region in patients with chronic generalized periodontitis and premature occlusal contacts are realized in a statistically significant increase in the biopotentials of the masticatory muscle group at rest, a decrease in biopotentials during functional loading, as well as a reduction in the values of symmetry and synergy in relation to similar values patients of group 1.
Організація діяльності Міського Товариства взаємного страхування майна від вогню в кінці ХІХ століття (на прикладі міста Харкова)
Authors: Хорошев Олександр 
Published: May 2024

У статті розглядяться історія виникнення Товариства взаємного страхування від вогню в місті Харкові як одного з найстаріших подібних об’єднань Наддніпрянщини в кінці ХІХ ст. Особливу увагу автор приділяє організаційній структурі товариства, його управлінню та фінансовій діяльності. Аналіз діяльності та організаційних принципів існування Товариств взаємного страхування дозволяє висвітлити побут українського міста тієї епохи та стан соціальної підтримки міського населення. Вивчення вітчизняних традицій системи взаємного страхування майна від пожеж є важливим у процесі становлення та подальшого удосконалення сучасної системи соціальної підтримки населення, у тому числі економічного захисту населення від збитків, нанесених пожежами, бойовими діями, природними катаклізмами тощо. Тому історичний аналіз розвитку страхування може дозволити уникнути фатальних помилок у його подальшому становленні та майбутньому розвиткові нашої країни.
Одеса під владою червоних «військових начальників»: особливості військової окупації Одещини (квітень 1919 р.)
Authors: Савченко Віктор 
Published: May 2024

Стаття присвячена аналізу формування московської військової диктатури в Одесі у квітні 1919 р., процесу формування армії «вторгнення» – 3-ї Української радянської армії, яку Москва планувала використати для війни проти Румунії та «походу на Європу». Московський колоніалізм проявився у тому, що всі владні рішення приймалися «посланцями Москви», які формували військові структури, надзвичайні методи влади, відсторонивши від прийняття владних рішень місцеве самоврядування та ради. Військові структури червоної армії в Україні формувалися з місцевих повстанців, які були введені в оману примарними обіцянками більшовиків. На плечі повстанців та їхніх ватажків сідали нові господарі життя – московські більшовицькі керівники та червоні військові командири, що перетворювали життя в містах і селах України на надзвичайний військовий режим. У той же час ці «лідери охласу» так і не змогли організувати на Півдні України чітку структуру військового командування та міської влади. Повний хаос в управлінні, «війна штабів», доповнювалася колонізаторською політикою червоних окупантів українських теренів. У квітні 1919 р. Україна була в стані гострого соціального, політичного та національного конфлікту, повстанці, з яких складалися частини 3-ї української радянської армії не підтримали утвердження «військового комунізму» й сама ця армія створювалася як примарне формування з вкрай завищеними показниками особистого складу.
3-я Українська радянська армія у хаосі самознищення (травень 1919 р.)
Authors: Савченко Віктор 
Published: May 2024

Стаття присвячена аналізу подій на південному заході України пов’язаних з повстанням отамана Н. Григор’єва. Розглядаючи особливості російської агресії в Україні у 1919 р., треба зазначити, що російський колоніалізм, використовуючи оманливу пропаганду, спромігся залучити значну частину мешканців України до трьох червоних армій радянського Українського фронту. Але, в травні 1919 р. частини 3-ї армії цього фронту повстали проти колоніальної політики «червоної» влади. На Півдні України отаману Н. Григор’єву вдалося підняти на повстання не тільки свою 6-ту дивізію 3-ї армії, але й частини 5-ї дивізії, радянські гарнізони Миколаєва, Херсона, Очакова, невдала спроба повстання військових фіксувалася в Одесі. Можна твердити, що в середині травня 1919 р. 3-я армія Українського фронту опинилася в стані руйнації та хаосу, з якого вона так і не вийшла до своєї ліквідації у червні 1919 р. Повстання отамана Н. Григор’єва зруйнувала тили Червоної Армії, не давши їй змоги провести запланований «похід на Європу» (захоплення Румунії), зробивши її неспроможною опиратися наступу частин армії УНР і «білої» армії. Повстання показало силу українського спротиву «червоній» диктатурі та привела до загальної кризи владних інститутів, у той же час повстанці виявили свої вади: антисемітизм, що досяг рівня погромів, недисциплінованість частин, хаотичність військового стратегічного планування.
Identidade Profissional de Futuros Professores de Matemática:
Authors: Lira de Brito Leonardo , Fiorentini Dario 
Published: May 2024

Este artigo tem como objetivo descrever e analisar como a Identidade Profissional Docente (IPD) de futuros professores de matemática (FPM) vem sendo abordada nos diferentes contextos formativos discutida em pesquisas brasileiras (Dissertações e teses) e quais contribuições são evidenciadas para a formação inicial. Para isso fizemos uma revisão da literatura do tipo estado do conhecimento dos últimos 10 anos (2013 a 2022) disponíveis na Biblioteca Nacional de Teses e Dissertações (BDTD) e no catálogo de teses e dissertações da CAPES que discutem acerca da identidade profissional docente do futuro professor de matemática. Essas pesquisas mostram uma grande variedade de abordagens teóricas, objetivos e resultados, dentre os quais foram associados aos seus contextos de investigação, a saber: IPD de futuros professores de matemática no contexto do Estágio Supervisionado; IPD de futuros professores de matemática no contexto do PIBID; IPD de futuros professores de matemática no contexto do Programa de Residência Pedagógica (PRP); IPD de futuros professores de matemática no contexto da educação a distância e IDP de futuros professores de matemática em outros contextos. A partir do estudo realizado, considera-se que a IPD de futuros professores de matemática se apresenta como um campo de investigação promissor para área de formação inicial de futuros professores de matemática.
Atividade Orientadora de Ensino na Educação de Jovens e Adultos: compreensões das professoras
Authors: Guimarães Jez Andreia , Liduário Cyone Soares Pereira , Rodrigues Jocimara Rossa , Vendrametto Mara Sueli , Panossian Maria Lucia , Gonçalez Mirian Maria Andrade 
Published: May 2024

O objetivo deste artigo é apresentar a experiência de professoras que lecionam na modalidade de ensino da Educação de Jovens e Adultos em uma escola do município de Piraquara-PR. A experiência demonstra como as professoras articularam em sua prática pedagógica os pressupostos teóricos e metodológicos da Atividade Orientadora de Ensino (AOE) em sala de aula. As interações aconteceram durante as reuniões na Oficina Pedagógica de Matemática (OPM), uma ação de extensão da universidade na escola, por meio de um processo formativo de professores cuja intenção é proporcionar interações que atribuam novo sentido à organização do ensino, problematizando os desafios e potencialidades da Atividade Orientadora de Ensino no contexto da Educação de Jovens e Adultos. O projeto possibilitou que as professoras se colocassem em um movimento que instiga a reflexão teórico e prática, sistematizando ações que envolvem conceitos matemáticos com função social, contribuindo para a aprendizagem e desenvolvimento dos estudantes da Educação de Jovens e Adultos. As professoras discutiram e adaptaram uma Situação Desencadeadora de Aprendizagem elaborada na OPM considerando os estudantes jovens e adultos e a desenvolveram em sala de aula. A partir disso, se conscientizaram das mudanças que ocorreram em sua prática pedagógica pela mediação da AOE, o que gerou resultados positivos em suas ações e nas dos estudantes, sendo que esta forma de organizar o ensino se mostrou como uma proposta eficaz de ensinar e aprender os conceitos matemáticos.
Metode Pembelajaran, E-Learning, Siswa
Authors: Fauzi Rahmat , Arista Anggia 
Published: May 2024

Internet merupakan jaringan global antar komputer untuk berkomunikasi dari satu lokasi ke lokasi lainnya di belahan dunia seperti sekolah, universitas, institusi riset, museum, bank, perusahaan bisnis, perorangan, stasiun TV ataupun radio. Internet berfungsi sebagai aspek komunikasi, penyedia informasi, dan fasilitas untuk promosi. Internet, kata yang tidak asing di telinga setiap orang, terutama para remaja yang senantiasa bergaul melalui situs jejaring sosial. Selain itu, penggunaan internet sebagai media pembelajaran dilatar belakangi oleh Masalah keterbatasan sumber informasi konvensional tidak dapat memenuhi harapan siswa untuk mendapatkan informasi yang layak dan berguna sebagai bahan referensi pembelajaran di kelas. Adanya Internet merupakan salah satu solusi pamungkas untuk mengatasi masalah ini. Internet menghilangkan batas ruang dan waktu sehingga memungkinan seorang siswa berkomunikasi dengan pakar di tempat lain. Internet dalam fungsinya sebagai penyedia informasi sangat membantu siswa dalam proses pembelajaran. E-learning merupakan singkatan dari Elektronic Learning, merupakan cara baru dalam proses belajar mengajar yang menggunakan media elektronik khususnya internet sebagai sistem pembelajarannya. E-learning merupakan dasar dan konsekuensi logis dari perkembangan teknologi informasi dan komunikasi.. Diharapkan dengan adanya pelatihan penggunaan E-learning dalam proses belajar mengajar dapat membantu para siswa dan juga tenaga pendidik dalam menambah wawasan dan mendapatkan materi baru yang lebih banyak dan dapat digunakan dalam pembelajaran kususnya pada Yayasan Sahabat Cendikia
The myxozoans Myxobolus cerebralis and Tetracapsuloides bryosalmonae modulate rainbow trout immune responses: quantitative shotgun proteomics at the portals of entry after single and co-infections
Authors: Saleh Mona , Hummel Karin , Schlosser Sarah , Razzazi-Fazeli Ebrahim , Bartholomew Jerri L. , Holzer Astrid , Secombes Christopher J. , El-Matbouli Mansour 
Published: May 2024

IntroductionLittle is known about the proteomic changes at the portals of entry in rainbow trout after infection with the myxozoan parasites, Myxobolus cerebralis, and Tetracapsuloides bryosalmonae. Whirling disease (WD) is a severe disease of salmonids, caused by the myxosporean M. cerebralis, while, proliferative kidney disease (PKD) is caused by T. bryosalmonae, which instead belongs to the class Malacosporea. Climate change is providing more suitable conditions for myxozoan parasites lifecycle, posing a high risk to salmonid aquaculture and contributing to the decline of wild trout populations in North America and Europe. Therefore, the aim of this study was to provide the first proteomic profiles of the host in the search for evasion strategies during single and coinfection with M. cerebralis and T. bryosalmonae.MethodsOne group of fish was initially infected with M. cerebralis and another group with T. bryosalmonae. After 30 days, half of the fish in each group were co-infected with the other parasite. Using a quantitative proteomic approach, we investigated proteomic changes in the caudal fins and gills of rainbow trout before and after co-infection.ResultsIn the caudal fins, 16 proteins were differentially regulated post exposure to M. cerebralis, whereas 27 proteins were differentially modulated in the gills of the infected rainbow trout post exposure to T. bryosalmonae. After co-infection, 4 proteins involved in parasite recognition and the regulation of host immune responses were differentially modulated between the groups in the caudal fin. In the gills, 11 proteins involved in parasite recognition and host immunity, including 4 myxozoan proteins predicted to be virulence factors, were differentially modulated.DiscussionThe results of this study increase our knowledge on rainbow trout co-infections by myxozoan parasites and rainbow trout immune responses against myxozoans at the portals of entry, supporting a better understanding of these host-parasite interactions.
Holography-guided procedural planning for modifying Venus P-valve implantation technique in patients with left pulmonary artery stents: a case-series
Authors: d’Aiello Angelo Fabio , Schianchi Laura , Bevilacqua Francesca , Ferrero Paolo , Micheletti Angelo , Negura Diana Gabriela , Pasqualin Giulia , Chessa Massimo 
Published: May 2024

BackgroundVenus P-valve™ (Venus Medtech, Hangzhou, China) is a self-expandable bioprosthetic valve that can be transcatheter-implanted in native right ventricular outflow tract (RVOT) patients. Valve implantation is technically challenging. Due to the implantation technique, left pulmonary artery (LPA) stents represent a relative contraindication to Venus P-valve. In this case series, we describe our experience in implanting Venus P-valve in patients with previous LPA stents and the use of holographic models to facilitate procedural planning.Methods and resultsFrom January to October 2023, 17 patients were scheduled for Venus P-Valve implantation. 16/17 (94%) patients were successfully implanted. 3/16 (18.7%) patients underwent Venus P-valve implantation with LPA stents. All patients underwent pre-operative CT scan. CT data set were employed to create three-dimensional (3D) holographic models (Artiness, Milan, Italy) of the entire heart, which were useful to plan valve implantation with a modified technique. Procedural success rate was 100%. No procedural complications occurred. All three patients presented good haemodynamic and angiographic results at discharge and follow-up visits.ConclusionThis case-series underscores the feasibility of Venus P-valve implantation in patients with previous LPA stents. The use of holographic models facilitated procedural planning in these challenging anatomical scenarios.
Progressive multifocal leukoencephalopathy reports in rheumatoid arthritis concerning different treatment patterns-an exploratory assessment using the food and drug administration adverse event reporting system
Authors: Honma Takeshi , Onda Kenji , Masuyama Koichi 
Published: May 2024

Introduction: Progressive multifocal leukoencephalopathy (PML) is a rare but potentially life-threatening brain infection caused by the John Cunningham virus. PML is a known adverse effect associated with molecular-targeted drugs and immunosuppressive agents. Recent concerns have emerged regarding the link between methotrexate (MTX) and PML. However, limited information exists on the influence of concomitant drug use in rheumatoid arthritis (RA) treatment, where various medications are often used together.Methods: To explore treatment patterns and patient background that affect PML reporting in RA, we analyzed data on RA cases from the Food and Drug Administration Adverse Event Reporting System (FAERS; JAPIC AERS) database between 1997 and 2019.Results and Discussion: Our analysis revealed significantly elevated crude and adjusted reporting odds ratios (aROR) for MTX, rituximab (RIT), azathioprine, and cyclophosphamide. When considering treatment patterns, the concomitant use of MTX and RIT showed a higher aROR than using MTX or RIT alone. Additional TNF-α inhibitors or glucocorticoids did not increase PML reports. Moreover, male sex and older age were associated with increased PML reports. While limitations are inherent in studies using spontaneous reporting data, our exploratory assessment suggests an association between PML and the combination of MTX and RIT and a higher risk in men and older patients. These findings help enhance our understanding of PML risk factors in the context of RA treatment.
Online poetry writing at school – comparing lower secondary students’ experiences between individual and collaborative poetry writing
Authors: Kangasharju Arja. I. , Ilomäki Liisa , Toom Auli 
Published: May 2024

IntroductionThis study investigates how seventh-grade students experience online collaborative writing, its support in writing poems, and how collaboratively and individually written poems differ.MethodsThe educational design research method was used in this mixed-methods study, which was conducted in natural classroom settings to investigate students’ individual and collaborative poetry writing.ResultsThe quantitative analysis of questionnaires and qualitative thematic analysis of postexperimental interviews show that the students enjoyed collaborative writing more and found it more accessible than individual writing. They experienced that it supported them in writing better poems and increased their writing confidence. They also appreciated the support of teamwork, although individual writing gave them more liberty to explore various aspects of poetry and express their feelings.DiscussionFrom a pedagogical point of view, the students need to be provided with opportunities for collaborative poetry writing to make the writing process easier and more enjoyable. Online collaborative writing supports the process of poetry writing.
A novel nomogram and prognostic factor for metastatic soft tissue sarcoma survival
Authors: Han Dan , Li Bing , Xu Jie , Hu Yajie , Chen Xi , Wang Ruizhi 
Published: May 2024

BackgroundThis study represented the inaugural effort to develop predictive survival nomograms for metastatic soft tissue sarcoma (mSTS) patients in the era of immune checkpoint inhibitors.MethodFrom the Surveillance, Epidemiology, and End Results (SEER) program database, we extracted 3078 eligible patients with mSTS between 2016 and 2022. Kaplan-Meier survival analysis, univariate and multivariable Cox analyses, and univariate and multivariable logistic analyses were conducted. Subsequently, predictive nomograms were constructed. Clinical effectiveness was validated using the area under the curve (AUC), calibration curve, and decision curve analysis (DCA) methods.ResultsWe used the SEER database to include 3078 eligible patients with mSTS between 2016 and 2022. All the eligible patients were randomly allocated in a ratio of 6:4 and stratified into a training group (n = 1846) and a validation group (n = 1232). In the multivariate Cox analysis, age, race, marital status, pathological grade, histologic subtype, surgery, and chemotherapy were identified as independent prognostic factors. These factors were used to construct the nomogram to predict the 1-, 3-, and 5-year OS of mSTS patients. The C-index for the training cohort and the validation cohort was 0.722(95% confidence interval [CI]: 0.708–0.736), and 0.716(95% CI: 0.698–0.734), respectively. The calibration curves for 1-, 3-, and 5-year OS probability demonstrated excellent calibration between the predicted and the actual survival. The AUC values of the nomogram at 1-, 3-, and 5-year were 0.785, 0.767, and 0.757 in the training cohort, 0.773, 0.754, and 0.751 in the validation cohort, respectively. Furthermore, DCA indicated the favorable clinical utility of the nomogram in both cohorts. The risk stratification system was constructed using the established nomogram, which enhanced prediction accuracy, aided clinicians in identifying high-risk patients and informing treatment decisions.ConclusionThis study marked the inaugural effort in constructing predictive survival nomograms mSTS patients in the era of immune checkpoint inhibitors. The robustly constructed nomograms, alongside actual outcomes, offered valuable insights to inform follow-up management strategies.
Causal relationship between type 2 diabetes mellitus and aortic dissection: insights from two-sample Mendelian randomization and mediation analysis
Authors: Zhang Weizong , Sun Jindong , Yu Huamin , Shi Minjuan , Hu Haiqiang , Yuan Hong 
Published: May 2024

ObjectiveSome evidence suggests a reduced prevalence of type 2 diabetes mellitus (T2DM) in patients with aortic dissection (AD), a catastrophic cardiovascular illness, compared to general population. However, the conclusions were inconsistent, and the causal relationship between T2DM and AD remains unclear.MethodsIn this study, we aimed to explore the causal relationship between T2DM and AD using bidirectional Mendelian randomization (MR) analysis. Mediation MR analysis was conducted to explore and quantify the possible mediation effects of 1400 metabolites in T2DM and AD.ResultsThe results of 26 datasets showed no causal relationship between T2DM and AD (P&gt;0.05). Only one dataset (ebi-a-GCST90006934) showed that T2DM was a protective factor for AD (I9-AORTDIS) (OR=0.815, 95%CI: 0.692-0.960, P=0.014), and did not show horizontal pleiotropy (P=0.808) and heterogeneity (P=0.525). Vanillic acid glycine plays a mediator in the causal relationship between T2DM and AD. The mediator effect for vanillic acid glycine levels was -0.023 (95%CI: -0.066-0.021).ConclusionFrom the perspective of MR analysis, there might not be a causal relationship between T2DM and AD, and T2DM might not be a protective factor for AD. If a causal relationship does exist between T2DM and AD, with T2DM serving as a protective factor, vanillic acid glycine may act as a mediator and enhance such a protective effect.