bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social isolation and mental well-being among Korean older adults: a focus on living arrangements
Authors: Lee Geon , Kim Chulwoo 
Published: April 2024

IntroductionThe aging population in South Korea, characterized by an increasing number of older adults living alone, has raised concerns about its implications on mental health, specifically social isolation and loneliness that accompanies solitary living arrangements. This study explores the impact of living arrangements on the mental well-being of Korean older adults by focusing on the prevalence of depression and the role of social isolation in the context of evolving family structures and the COVID-19 pandemic.MethodsThis cross-sectional study analyzed the responses of older adults aged 65 years and above (mean: 73.1, SD: 5.1) by using data from the Korea National Health and Nutrition Examination Survey conducted in 2018 and 2020. In total, responses from 3,365 older adults (1,653 in 2018 and 1,712 in 2020) were employed in this research. The participants’ mental health status was assessed using the Patient Health Questionnaire-9, with living arrangements categorized by household size. A zero-inflated Poisson regression analysis was employed to investigate the relationship between living arrangements and depression severity, controlling for demographic, socioeconomic, and psychological factors.ResultsThe study found that older adults living with others exhibited a lower depression severity than those living alone. Notably, the severity of depression decreased as the number of household members increased up to a certain threshold. Socio-economic factors, such as income level, marital status, and psychological stress were also identified as significant predictors of depression severity. However, the COVID-19 pandemic did not have a statistically significant impact on depression rates among older adults during the study period.ConclusionLiving arrangements play a critical role in the mental health of Korean older adults, with solitary living being associated with higher levels of depression. These findings underscore the importance of social support systems and suggest the need for policies and interventions that promote social connectivity and address the challenges of loneliness faced by them. Future research should explore longitudinal and qualitative studies to further understand causal relationships and develop targeted interventions to improve the mental well-being of the aging population.
Patient perspectives on BCMA-targeted therapies for multiple myeloma: a survey conducted in a patient advocacy group
Authors: Hydren Jay R. , Lin Dee , Sweeney Nathan W. , Wu Bingcao , Kim Nina , Patel Saurabh , Sborov Douglas W. , Berdeja Jesus G. , Anderson Larry D. , Huo Stephen , Hurtado Martínez Jorge Arturo , Ahlstrom Jennifer M. 
Published: April 2024

BackgroundAdvances in multiple myeloma (MM) treatment have shifted the therapeutic landscape. Understanding patients' perspectives can assist physicians in helping patients make informed decisions. This study aimed to understand the patient decision-making process and gain insights into patient perspectives on B-cell maturation antigen (BCMA)-targeted therapies for MM.MethodsAn 18-question survey was completed by patients with MM enrolled in HealthTree® Cure Hub, an online portal helping patients with plasma cell dyscrasias navigate their disease.ResultsFrom October 28, 2022, to January 12, 2023, 325 patients with MM participated in the survey. The mean age (standard deviation) of the respondents was 66 (8) years; 54% were female and 90% were White. Among 218 patients with complete clinical records in the database, the median (min, max) lines of therapy (LOT) was 2 (1,16). Among 61 (28%) patients who had received ≥4 LOTs, 55 (90%) were triple-class exposed. Of the 290 patients who responded to the question about openness to new therapies, 76 (26%) were open to trying a new therapy immediately and 125 (43%) wanted more information on safety and efficacy. Most respondents reported likely or very likely to try a BCMA CAR T-cell therapy (60%) or a bispecific antibody (74%) and some needed more information to decide (16% for CAR T-cell therapy and 13% for bispecific antibody). The most requested information included efficacy, side effects (SEs), eligibility, and administration process for both CAR T-cell and bispecific therapies. When 2 therapies with the same efficacy and duration of response were offered, 69% of respondents would prefer the therapy with a lower risk of severe SEs but requires continuous dosing with no treatment-free interval, and 31% preferred a therapy given once followed by a treatment-free interval but with a potentially higher risk of severe SEs. To receive an effective therapy, the top acceptable trade-offs included frequent monitoring of SEs and initiating a new therapy in a hospital setting, and the least acceptable compromise was caregiver burden.ConclusionsThis study found a high level of openness in patients with MM to try BCMA-targeted therapies. Information on efficacy, safety, availability, and eligibility may assist patients on decision-making.
Differences in income, farm size and nutritional status between female and male farmers in a region of Haiti
Authors: Duvivier Predner , Tescar Robers Pierre , Halliday Cassandra , Murphy Madhuvanti M. , Guell Cornelia , Howitt Christina , Augustus Eden , Haynes Emily , Unwin Nigel 
Published: April 2024

IntroductionHaiti is the poorest country in the Americas and has the highest levels of gender inequality. It has high burdens of malnutrition and food insecurity. Our aim in this study was to investigate differences between female and male heads of farms in their farm's size and income and in their nutritional status.MethodsWe conducted a mixed-method study with a quantitative survey with 28 female and 80 male farmers and qualitative semi-structured interviews with seven women and 11 men, in nine rural communities, Plateau de Rochelois, Nippes, Haïti.ResultsWe found that significant inequalities existed between female and male heads of farms in this region of Haiti. Farm income was associated with farm size, with female farmers having on average smaller farms, and markedly lower farm incomes compared to male farmers, even after adjusting for the fact that their farms were smaller. Male farmers also had more access to seeds, financing and transportation to market. In addition, female farmers had markedly higher levels of overweight and obesity. In both male and female heads of farms around 1 in 20 were underweight.DiscussionThese findings complement those from other settings, showing that female farmers in low- and middle- income countries typically face severe challenges in accessing resources such as land, credit, and inputs, which can limit their productivity and income-generating potential. Gender sensitive interventions to promote farmer health, well-being and productivity are required.
Malignant peritoneal mesothelioma presenting with bilateral hydronephrosis and renal insufficiency: a case report and literature review
Authors: Luo Jisheng , Pan Jinhong , Zhong Chuanhua , Wang Lina , Zhang Heng 
Published: April 2024

IntroductionMalignant peritoneal mesothelioma (MPM) is an extremely rare tumor with nonspecific clinical manifestations, making diagnosis challenging.Case presentationHerein, we report a case of MPM with occult onset presenting with bilateral hydronephrosis and renal insufficiency. A 30-year-old man was admitted to the Urology Department because of recurrent bilateral lower back pain. The etiology was unclear after a series of laboratory tests, imaging examinations, bone marrow aspiration, renal puncture biopsy, ascites examination, ureteroscopy, and so on. Finally, MPM was diagnosed by laparoscopic exploration and biopsy. Moreover, during the course of the disease, the patient's bilateral ureters were compressed, and the obstruction could not be relieved after the placement of ordinary ureteral stents. Percutaneous nephrostomy or metal ureteral stenosis was appropriate in managing malignant ureteral obstruction as it could improve renal function.ConclusionsThe onset of this case was insidious, and the diagnosis was difficult, with a poor prognosis. To date, only a handful of cases have been reported. We hope this case can provide some enlightenment for our clinical work.
Comparison of the analgesic effects of oxycodone vs. sufentanil on postoperative pain after laparoscopic gallbladder-preserving cholecystolithotomy: a prospective randomized controlled trial
Authors: Wang Ye , Wu Meng , Zhao Lin , Yan Xiaojian , Zhao Lei 
Published: April 2024

BackgroundWe aimed to compare the anesthesia induction effects of oxycodone and sufentanil on postoperative pain in patients undergoing laparoscopic gallbladder-preserving cholecystolithotomy, as well as changes in serum levels of inflammatory factors (TNF-α, IL-6, and IL-10) in the perioperative period.MethodsSixty patients who underwent laparoscopic gallbladder-preserving cholecystolithotomy were evenly divided into oxycodone (O) and sufentanil (S) groups. In groups O and S, oxycodone (0.3 mg/kg) and sufentanil (0.3 ug/kg) were administered, respectively, followed by propofol (2 mg/kg) and rocuronium (0.6 mg/kg). In both groups, the intraoperative electroencephalography double-frequency index was used to guide the use of sedative and analgesic drugs, assessing the follow-up analgesic effect (VAS), degree of sedation (Ramsey), and postoperative complications at seven different time points (0, 0.5, 2, 4, 6, 8, and 24 h postoperatively).ResultsCompared with the S group, patients in the O group exhibited lower VAS scores within 24 h postoperatively (P &lt; 0.001), but there was no statistical difference between wound and shoulder pain scores (P &gt; 0.05). Regarding postoperative awakening and extubation duration, O group patients experienced shorter times and better remedial analgesia (P &lt; 0.05). In terms of the degree of sedation, the Ramsay score decreased at 0 h postoperatively compared with the S group (P &lt; 0.001).ConclusionCompared with sufentanil, oxycodone anesthesia induced better postoperative analgesia and less inflammatory responses in patients undergoing laparoscopic gallbladder-preserving cholecystolithotomy.Clinical Trial RegistrationThis study has been approved by the Ethics Committee of Peking University Shougang Hospital, with ethical approval (No. IRBK-2020-009), and has completed registration in the Chinese Clinical Trials Register (http://www.chictr.org.cn/) (ChiCTR2000031230).
Multidrug-Resistant Escherichia coli Remains Susceptible to Metal Ions and Graphene-Based Compounds
Authors: Karaky Nathalie , Tang Shiying , Ramalingam Parameshwari , Kirby Andrew , McBain Andrew J. , Banks Craig E. , Whitehead Kathryn A. 
Published: April 2024

Escherichia coli is listed as a priority 1 pathogen on the World Health Organization (WHO) priority pathogen list. For this list of pathogens, new antibiotics are urgently needed to control the emergence and spread of multidrug-resistant strains. This study assessed eighteen metal ions, graphene, and graphene oxide for their antimicrobial efficacy against E. coli in both planktonic and biofilm growth states and the potential synergy between metal ions and graphene-based compounds. Molybdenum and tin ions exhibited the greatest antimicrobial activity against the planktonic states of the isolates with minimal inhibitory concentrations (MIC) ranging between 13 mg/L and 15.6 mg/L. Graphene oxide had no antimicrobial effect against any of the isolates, while graphene showed a moderate effect against E. coli (MIC, 62.5 mg/L). Combinations of metal ions and graphene-based compounds including tin–graphene, tin–graphene oxide, gold–graphene, platinum–graphene, and platinum–graphene oxide exhibited a synergistic antimicrobial effect (FIC ≤ 0.5), inhibiting the planktonic and biofilm formation of the isolates regardless of their antibiotic-resistant profiles. The bactericidal effect of the metal ions and the synergistic effects when combined with graphene/graphene oxide against medically relevant pathogens demonstrated that the antimicrobial efficacy was increased. Hence, such agents may potentially be used in the production of novel antimicrobial/antiseptic agents.
Beampattern Synthesis and Optimization Method Based on Circular Frequency Diverse Array Engineering Model
Authors: Xu Wei , Pei Changyu , Huang Pingping , Tan Weixian , Gao Zhiqi 
Published: April 2024

The frequency diverse array (FDA) is capable of generating range-angle-dependent beampatterns by introducing a tiny frequency offset to the transmit carrier frequency of each array element. However, the beam-scanning potential of conventional linear FDA applications is limited, notably in their incapacity for 360° omnidirectional scanning. This paper introduces a method that leverages the geometric configuration of circular frequency diverse arrays (CFDAs) for synthesizing and optimizing beampatterns through a practical engineering approach. Initially, we compute the structural parameters and configurations of CFDA. Subsequently, the isophase plane is utilized to adjust the phase of each array element. Ultimately, the CFDA structure is used to optimize the non-uniform frequency offset, and the beampattern, which is capable of 360° omnidirectional scanning, is realized by low sidelobe optimization. Simulation results affirm that the CFDA antenna, as per the actual engineering model, possesses precise dot-shaped beampattern scanning abilities across both range and angle dimensions.
Linear Fiber Laser Configurations for Optical Concentration Sensing in Liquid Solutions
Authors: Soares Liliana , Perez-Herrera Rosa Ana , Novais Susana , Ferreira António , Silva Susana , Frazão Orlando 
Published: April 2024

In this study, different configurations based on linear fiber lasers were proposed and experimentally demonstrated to measure the concentration of liquid solutions. Samples of paracetamol liquid solutions with different concentrations, in the range from 52.61 to 201.33 g/kg, were used as a case-study. The optical gain was provided by a commercial bidirectional Erbium-Doped Fiber Amplifier (EDFA) and the linear cavity was obtained using two commercial Fiber Bragg Gratings (FBGs). The main difference of each configuration was the coupling ratio of the optical coupler used to extract the system signal. The sensing head corresponded to a Single-Mode Fiber (SMF) tip that worked as an intensity sensor. The results reveal that, despite the optical coupler used (50:50, 60:40, 70:30 or 80:20), all the configurations reached the laser condition, however, the concentration sensing was only possible using a laser drive current near to the threshold value. The configurations using a 70:30 and an 80:20 optical coupler allowed paracetamol concentration measurements with a higher sensitivity of (−3.00 ± 0.24) pW/(g/kg) to be performed. In terms of resolution, the highest value obtained was 1.75 g/kg, when it was extracted at 20% of the output power to the linear cavity fiber laser configuration.
Atuação do profissional farmacêutico no combate do uso irracional de medicamento durante a pandemia da SARS-CoV-2: uma revisão integrativa de literatura
Authors: Rocha João Marcos Rodrigues , Dutra Aline Soares de Santana , Dutra Rafael Filipe Ferreira , Gomides Rafael Rodrigues , França Stephany Martins de Almeida , Oliveira Kleberson de , Souza Verônica Duarte de 
Published: April 2024

Automedicação é um dos principais problemas de saúde mundial, provocando mascaramento dos sinais e sintomas de doenças de baixa e alta gravidade. A falta de profissionais de saúde, erro de prescrição, erro de diagnóstico, prescrição ilegível tornou-se os principais fatores do uso incorreto e inapropriado de medicamentos. O farmacêutico junto com uma equipe multidisciplinar promove o uso correto de medicamentos, diminuindo os efeitos adversos, intoxicação medicamentosa, interação medicamentosa e óbito. Com a pandemia da Covid-19, a falta de leitos, vagas em hospitais, profissionais de saúde e o isolamento social acentuou aumento na prática da automedicação. As informações ou fake news sobre tratamento precoce, sem embaseamento cientifico, é possível acarretar diversas ocorrências de efeitos colaterais. Objetivo desta pesquisa é mostrar a importância do farmacêutico no combate do uso irracional de medicamentos na pandemia da covid-19. É uma pesquisa de revisão integrativa de literatura, com dados coletados no ano de 2019-2022, na plataforma do Google Acadêmico, BVS e Scielo. A pesquisa demontrou que o farmacêutico é o profissional de saúde com habilidades no comabate a uso incoreto e desnecessário de medicamentos, diminuindo os riscos gerados por medicamentos utilizados de forma inapropriada com acompanhamento farmacoterapêutico.
Evaluation of cutoff characteristics in oscillating liquid crystal molecules under sinusoidal electric fields
Authors: Inoue Yo , Shikada Tateaki , Bono Shinji , Moritake Hiroshi 
Published: April 2024

Abstract
Sinusoidal electric fields are applied to liquid crystals (LCs) across various frequencies ranging from 0.1 Hz to 10 kHz to investigate the oscillatory behavior of LC directors. In a 1.5 μm thick 5CB cell, a significant decline in refractive index change occurs in the frequency range greater than 10 Hz, in which the LC director cannot sufficiently follow the rapid fluctuations in field intensity. To evaluate the response speed of the LCs under sinusoidal electric fields, the cutoff frequency is introduced as a response indicator. Enhancement of the cutoff frequency can be achieved through conventional fast response techniques such as polymer-stabilized LCs.
Il lavoro come storia. Il contributo marxista di Antonio Labriola
Authors: Basile Luca 
Published: April 2024

The script addresses the role of the theme of work in Labriola's thought, and attempts to demonstrate how this can be assumed as the key to all of his Marxist reflection. "Self-government of work", construction of an "artificial ground" thanks to working praxis, primacy of praxis itself: these are the conceptual passages that attest this centrality. The text tries to account for this in their development.
TREN PEMANFAATAN TIK TOK OLEH MEDIA ONLINE LOKAL DI KOTA BATAM
Authors: Abidin Sholihul , Purwanti Angel , Cindoswari Ageng Rara 
Published: April 2024

Penetrasi penggunaan medsos TikTok oleh masyarakat mendorong media massa ikut mengimbangi pemanfaatan medsos guna menyasar netizen. Tidak sedikit media-media online nasional maupun lokal yang memiliki medsos TikTok sebagai sarana dan media komunikasi institusi kepada publik. Di Kota Batam sendiri masih belum banyak media online yang memanfaatkan platform TikTok sebagai akun medsos resmi institusi. Berdasarkan hasil observasi yang dilakukan terhadap media online lokal di Kota Batam, terdapat dua media yang memanfaatkan platform medsos TikTok yaitu tribunbatam dan batamnews. Kedua media ini memiliki akun medsos TikTok dengan jumlah followers atau pengikut yang cukup banyak. Hingga 12 November 2021, akun tik tok tribunbatam memiliki 666,2 ribu pengikut serta sudah terverifikasi. Sedangkan batamnews memiliki pengikut sebanyak 71,8 ribu pengikut. Kedua media ini merupakan representasi media online lokal di batam yang telah memanfaatkan tik tok sebagai salah satu platform medsos resmi. Klasifikasi konten Tribun Batam dan Batam News adalah konten informasi terkini. Informasi yang banyak dijadikan konten adalah konten artis, berita gossip, berita-berita popular (viral), yang dikemas dalam bentuk gambar bergerak, video-video pendek sementara untuk sumber data kontennya variatif dari produksi sendiri serta sumber-sumber lain. Baik tribun batam maupun batam news sama-sama memanfaatkan media sosial tiktok sebagai alat pendukung website berita.
Partisipasi Perempuan pada Usahatani Hortikultura Unggulan di Kabupaten Agam
Authors: Haditia Mega , R. Panuju Dyah , A. Kinseng Rilus 
Published: April 2024

Kawasan pertanian berbasis agropolitan di Kabupaten Agam merupakan kawasan yang mampu menjalankan sistem dan usaha agribisnis di dalam kawasan serta menjalin kerja sama dengan kawasan lainnya. Di dalam kawasan pertanian tersebut terdapat komoditas hortikultura unggulan yang menjadi komoditas andalan dalam menyokong perekonomian wilayah dan kesejahteraan masyarakat. Kegiatan pertanian berbasis agropolitan melibatkan banyak pihak di dalamnya termasuk perempuan. Namun sayangnya, partisipasi perempuan dalam pertanian belum terserap secara optimal. Penelitian ini bertujuan mengetahui komoditas hortikultura unggulan di Kabupaten Agam, menganalisis tingkat partisipasi perempuan pada komoditas unggulan tersebut, dan strategi untuk meningkatkan partisipasinya. Metode yang digunakan dalam penelitian ini adalah metode LQ, SSA, Analisis Kerangka Harvard, SWOT, dan QSPM. Hasil penelitian menunjukkan Kabupaten Agam memiliki tujuh komoditas unggulan di antaranya bawang merah, cabai besar, kubis, tomat, terung, kentang, dan buncis dengan tingkat partisipasi perempuan berada pada kategori sedang. Terdapat lima strategi yang direkomendasikan untuk meningkatkan paartisipasi perempuan pada usahatani hortikultura unggulan di Kabupaten Agam.
Differences in Mean Anti-Pertussis Antibody Levels in Children with Acellular Pertussis Immunization and Whole Pertussis Without Booster
Authors: Rezki Wenny Rahmalia , Rinang Mariko  , Rizanda Machmud  , Rusdi  , Asrawati  , Indra Ihsan  
Published: April 2024

Background: The incidence of pertussis is increasing every year, especially in developing countries. Low immunization coverage and decreased immunity are some of the factors causing the re-increase in pertussis cases. The protection provided by the pertussis vaccine whole and acellular pertussis given as a baby will decrease with age. This study aims to determine the difference in mean levels of anti-pertussis antibodies in children who received acellular pertussis and whole pertussis immunization without a booster.
Methods: A cross-sectional study was carried out at the pediatric polyclinic of Dr. M. Djamil General Hospital Padang from December 2022 to December 2023. Research subjects were children aged 5-9 years with a history of whole pertussis immunization (DPwT) 3 times or acellular pertussis immunization (DPaT) 3 times. The research subjects were examined for anti-pertussis antibody titers using the ELISA technique.
Results: Thirty-four children with a history of DPwT immunization 3 times and 34 children with a history of DPwT immunization 3 times were research subjects, with mean age 6.94±1.49 in the DPwT group and 6.88 ±1.61 in the DPaT group. The mean anti-pertussis antibody level in the DPwT group (9.54 IU/mL) was higher than the DPaT group (6.96 IU/mL) but was not statistically significant (p>0.05). The average antibody results showed that the antibody levels in both groups were below the antibody titer threshold that provides protection against pertussis. The results of the analysis showed that there was a significant difference in the incidence of AEFI between the DPwT and DPaT immunization groups (p<0.05).
Conclusion: There was no difference in anti-pertussis antibody levels in children who received DPwT and DPaT immunization 3 times. Pertussis immunization is a required booster so that antibody levels are sufficient to provide protection against pertussis.