bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rugulactone and its Analogues Exert Antibacterial Effects through Multiple Mechanisms Including Inhibition of Thiamine Biosynthesis
Authors: Nodwell Matthew B. , Menz Helge , Kirsch Stefan F. , Sieber Stephan A. 
Published: May 2012

AbstractRugulactone is a dihydro‐α‐pyrone isolated from the plant Cryptocarya rugulosa in 2009. It has been reported to display IkB kinase (IKK) inhibitory activity, as well as antibiotic activity in several strains of pathogenic bacteria. However, its biological targets and mode of action in bacteria have not yet been explored. Here we present enantioselective syntheses of rugulactone and of some corresponding activity‐based protein profiling (ABPP) probes. We found that the ABPP probes in this study are more potent than rugulactone against Staphyloccocus aureus NCTC 8325, S. aureus Mu50, Listeria welshimeri SLCC 5334 and Listeria monocytogenes EGD‐e, and that molecules of this class probably exert their antibacterial effect through a combination of targets. These targets include covalent inhibition of 4‐amino‐5‐hydroxymethyl‐2‐methylpyrimidine phosphate (HMPP) kinase (ThiD), which is an essential component of the thiamine biosynthesis pathway in bacteria. This represents the first example of a small‐molecule inhibitor of ThiD.
ChemInform Abstract: Ammonium and Caesium Carbonate Peroxosolvates: Supramolecular Networks Formed by Hydrogen Bonds.
Authors: Medvedev Alexander G. , Mikhaylov Alexey A. , Churakov Andrei V. , Prikhodchenko Petr V. , Lev Ovadia 
Published: May 2012

AbstractColorless single crystals of (NH4)2CO3·H2O2 (I) and Cs2CO3·3H2O2 (II) are prepared by cooling saturated solutions of (NH4)(COONH2) or Cs2CO3 in 98% H2O2 from room temperature to ‐18 °C.
ChemInform Abstract: The Incommensurately Modulated Structures of the Perovskites NaCeMnWO6 and NaPrMnWO6.
Authors: Garcia‐Martin Susana , King Graham , Nenert Gwilherm , Ritter C. , Woodward Patrick M. 
Published: May 2012

AbstractThe structures of the title perovskites are investigated by TEM, SAED, neutron, and synchrotron X‐ray powder diffraction.
ChemInform Abstract: Zero Thermal Expansion Fluid and Oriented Film Based on a Bistable Metal‐Cyanide Polymer.
Authors: Tokoro Hiroko , Nakagawa Kosuke , Imoto Kenta , Hakoe Fumiyoshi , Ohkoshi Shin‐ichi 
Published: May 2012

AbstractPlate‐shaped microcrystals of Rb0.97Mn [Fe(CN)6]0.99·0.3H2O are synthesized by mixing an aqueous solution containing polyethylene glycol monolaurate, MnCl2, and RbCl with an aqueous solution of polyethylene glycol monolaurate, K3[Fe(CN)6], and RbCl.
ChemInform Abstract: Low‐Temperature Sintering and Microwave Dielectric Properties of Li3MO4 (M: Ta, Sb) Ceramics.
Authors: Pang Li‐Xia , Liu Huan , Zhou Di , Yang Jia‐Xing , Li Dang‐Juan , Liu Wei‐Guo 
Published: May 2012

AbstractThe title ceramics are prepared by solid state reaction from mixtures of Li2CO3 and Ta2O5 or Sb2O3.
ChemInform Abstract: Critical Systematic Evaluation and Thermodynamic Optimization of the Mn—RE System: RE: La, Ce, Pr, Nd and Sm.
Authors: Kim Junghwan , Jung In‐Ho 
Published: May 2012

AbstractCritical evaluation and optimization of all available phase diagram and thermodynamic data for the title systems is conducted to obtain reliable thermodynamic functions of all the phases in the system.
ChemInform Abstract: Multivariate Method‐Assisted ab initio Study of Olivine‐Type LiMXO4 (Main Group M2+—X5+ and M3+—X4+) Compositions as Potential Solid Electrolytes.
Authors: Jalem Randy , Aoyama Takahiro , Nakayama Masanobu , Nogami Masayuki 
Published: May 2012

AbstractA combination of ab initio calculations and multivariate analysis is used to find potential solid electrolyte materials with low Li‐ion hopping energies among 66 olivine‐type oxides with an ordered LiMXO4 structure.
ChemInform Abstract: Ozone‐Based Atomic Layer Deposition of Crystalline V2O5 Films for High Performance Electrochemical Energy Storage.
Authors: Chen Xinyi , Pomerantseva Ekaterina , Banerjee Parag , Gregorczyk Keith , Ghodssi Reza , Rubloff Gary 
Published: May 2012

AbstractSingle‐phase, crystalline V2O5 thin films are prepared on various substrates (Si, Au‐coated stainless steel, anodic aluminium oxide) by atomic layer deposition from VO(OPr)3 and O3 (170—185 °C).
ChemInform Abstract: Halogenated Xenon Cyanides ClXeCN, ClXeNC, and BrXeCN.
Authors: Arppe Teemu , Khriachtchev Leonid , Lignell Antti , Domanskaya Alexandra V. , Raesaenen Markku 
Published: May 2012

AbstractThe title compounds are prepared by 193 nm photolysis and thermal annealing of ClCN and BrCN in a xenon matrix.
ChemInform Abstract: Two Novel Acentric Borate Fluorides: M3B6O11F2 (M: Sr, Ba).
Authors: McMillen Colin D. , Stritzinger Jared T. , Kolis Joseph W. 
Published: May 2012

AbstractCrystals of the new title compounds are synthesized by solid state reactions of MF2 (M: Sr, Ba), H3BO3, and NH4F (Pt crucible, 800 °C, 24 h) followed by hydrothermal reaction of the obtained powders with aqueous solutions of KF (for M: Sr) or KHF2 (for M: Ba) at 540 °C (welded silver ampules, 7 d).
ChemInform Abstract: Hydrothermal Synthesis and Crystal Structure of Two New Hydrated Alkaline Earth Metal Borates Sr3B6O11(OH)2 and Ba3B6O11(OH)2.
Authors: Heyward Carla , McMillen Colin , Kolis Joseph 
Published: May 2012

AbstractSr3B6O11(OH)2 (I) is synthesized by solid state reaction of LiOH, B2O3, Sr(OH)2, and KOH (Pt crucible, 900 °C in air, 16 h) followed by reaction of the obtained product with aqueous SrCl2 solution (autoclave, 560 °C, 6 d, 90% yield).
ChemInform Abstract: Extreme Differences in Oxidation States: Synthesis and Structural Analysis of the Germanide Oxometallates A10[Ge9]2[WO4] as well as A10+x[Ge9]2 [W1‐xNbxO4] with A = K and Rb Containing [Ge9]4‐ Polyanions.
Authors: Hlukhyy Viktor , Faessler Thomas F. , Ponou Simeon , Lidin Sven , Ivleva Natalia P. , Niessner Reinhard 
Published: May 2012

AbstractSemitransparent dark‐red or ruby‐red single crystals of K10.35Ge18W0.65Nb0.35 O4, Rb10.35Ge18W0.65Nb0.35 O4, K10Ge18WO4, and Rb10Ge18WO4 are synthesized by solid state reactions using K, Rb, Ge, W, WO3, K2WO4, Rb2WO4, GeO2 and HgO as starting materials (Nb crucible, 800 °C, 120 h).
ChemInform Abstract: Syntheses and Characterization of Nine Quaternary Uranium Chalcogenides Among the Compounds A2M3UQ6 (A: K, Rb, Cs; M: Pd, Pt; Q: S, Se).
Authors: Oh George N. , Choi Eun Sang , Ibers James A. 
Published: May 2012

AbstractCs2Pd3USe6 (50% yield), Cs2Pd3US6 (40% yield), Cs2Pt3USe6 (20% yield), Cs2Pt3US6 (20% yield), Rb2Pd3USe6 (50% yield), Rb2Pd3US6 (60% yield), Rb2Pt3USe6 (20% yield), Rb2Pt3US6 (20% yield), and K2Pd3US6 (40% yield) are synthesized by solid state reaction of U, Pd or Pt, and S or Se in ACl (A: K, Rb, Cs) or A2Qx (Q: S, Se) fluxes (1173—1223 K, 24—192 h).
ChemInform Abstract: Novel Triarylimidazole Redox Catalysts: Synthesis, Electrochemical Properties, and Applicability to Electrooxidative C—H Activation.
Authors: Zeng Cheng‐chu , Zhang Ni‐tao , Lam Chiu Marco , Little R. Daniel 
Published: May 2012

AbstractTAI is the most effective mediator to achieve the oxidation of benzyl alcohols and ethers in the presence of 2,6‐lutidine.
ChemInform Abstract: Rhodium‐Catalyzed and Zinc(II) Triflate Promoted Asymmetric Hydrogenation of Tetrasubstituted α,β‐Unsaturated Ketones.
Authors: Calvin Joel R. , Frederick Michael O. , Laird Dana L. T. , Remacle Jacob R. , May Scott A. 
Published: May 2012

AbstractA key feature is the use of catalytic zinc triflate, which significantly improves turnover frequency and suppresses epimerization in the α‐position of the products.
ChemInform Abstract: Stable Axial Chirality in Metal Complexes Bearing 4,4′‐Substituted BIPHEPs: Application to Catalytic Asymmetric Carbon—Carbon Bond‐Forming Reactions.
Authors: Aikawa Kohsuke , Miyazaki Yoshitaka , Mikami Koichi 
Published: May 2012

AbstractThe investigations reveal that not only electronic but also steric effects of 4,4′‐disubstituted BIPHEP derivatives (I) and their metal complexes influence the stability of the single bond rotation of biphenyl ring.
ChemInform Abstract: Acid—Base‐Catalyzed Condensation Reaction in Water: Isoxazolines and Isoxazoles from Nitroacetates and Dipolarophiles.
Authors: Trogu Elena , Vinattieri Claudia , De Sarlo Francesco , Machetti Fabrizio 
Published: May 2012

AbstractAlkenes or alkynes bearing a wide variety of functional groups including carboxylic acids and ammonium salts are subjected to optimized conditions.
ChemInform Abstract: Regio‐Selective Reduction of the C—C Double Bonds in α,β‐Unsaturated Acyl 4‐Substituted Oxazolidin‐2‐ones and Oxazolidine‐2‐thiones.
Authors: Li Shao‐Gang , Jin Jian‐Wei , Wu Yikang 
Published: May 2012

AbstractAn effective protocol for the regio‐ and chemoselective reduction of internal double bonds in α,β‐unsaturated 4‐substituted oxazolidine derivatives is developed.
ChemInform Abstract: Regio‐ and Stereoselective Hydroxybromination and Dibromination of Olefins Using Ammonium Bromide and Oxone®.
Authors: Macharla Arun Kumar , Nappunni Rohitha Chozhiyath , Nama Narender 
Published: May 2012

AbstractThe reagent mixture is efficiently used to convert a variety of non‐activated olefins to bromohydrins in aqueous MeCN.
ChemInform Abstract: Microwave‐Enhanced Triton B Catalyzed Suzuki Coupling Reaction.
Authors: Meshram H. M. , Prasad B. R. V. , Kumar D. A. , Reddy B. Ch. K. 
Published: May 2012

AbstractAn efficient method for the Suzuki coupling of aryl and heteroaryl halides with aryl and heteroaryl boronic acids is presented.
ChemInform Abstract: One‐Pot Synthesis of Enantiomerically Pure 1,2‐Diols: Asymmetric Reduction of Aromatic α‐Oxoaldehydes Catalyzed by Candida parapsilosis ATCC 7330.
Authors: Mahajabeen Pula , Chadha Anju 
Published: May 2012

AbstractThe position of the substituents on the aromatic ring of the oxoaldehydes has a large influence on the enantioselectivity and the configuration of the diols.
ChemInform Abstract: Direct Oxidative Conversion of 3‐Aryl Propionaldehydes to 3‐Aryl Acroleins Promoted by SOMO Catalysis.
Authors: Zhu Jin , Yu Shunting , Lu Wenchao , Deng Jing , Li Jian , Wang Wei 
Published: May 2012

AbstractThe transformation is efficiently achieved by an amine‐catalyzed CAN‐mediated single electron transfer oxidation process.
ChemInform Abstract: A Straightforward Synthesis of N‐Monosubstituted α‐Keto Amides via Aerobic Benzylic Oxidation of Amides.
Authors: Shao Jun , Huang Xiaomei , Wang Siyuan , Liu Bingxin , Xu Bin 
Published: May 2012

AbstractAn efficient, very simple, and convenient route to the title compounds (II) and (IV) starts from the easily available aryl‐ and heteroarylacetamides (I) and (III).
ChemInform Abstract: Oxidation of Acyclic Alkenes and Allyl and Benzyl Ethers with DIB/t‐BuOOH/Mg(OAc)2.
Authors: Sastraruji Thanapat , Pyne Stephen G. , Ung Alison T. 
Published: May 2012

AbstractThe ethers (VIII) and (XII) can be chemoselectively oxidized in the presence of a terminal alkene.
ChemInform Abstract: Thiophilic Nucleophilic Trifluoromethylation of α‐Substituted Dithioesters. Access to S‐Trifluoromethyl Ketene Dithioacetals and Their Reactivity with Electrophilic Species.
Authors: Gouault‐Bironneau Sonia , Timoshenko Vadim M. , Grellepois Fabienne , Portella Charles 
Published: May 2012

AbstractNucleophilic fluoroalkylation of dithioesters bearing a non‐enolizable α‐carbamoyloxy group (I) provides access towards S‐perfluoroalkyl ketene dithioacetals in good yields as E/Z‐mixtures.
ChemInform Abstract: Biodeposited Pd/Au Bimetallic Nanoparticles as Novel Suzuki Catalysts.
Authors: Heugebaert Thomas S. A. , De Corte Simon , Sabbe Tom , Hennebel Tom , Verstraete Willy , Boon Nico , Stevens Christian V. 
Published: May 2012

AbstractNanotype Pd and bimetallic Pd/Au materials are produced by reductive deposition of Na2PdCl2 or Na2PdCl4/HAuCl4 with Shewanella oneidensis growing overnight in Luria—Bertani medium.
ChemInform Abstract: ortho‐Methylated Tribenzotriquinacenes — Paving the Way to Curved Carbon Networks.
Authors: Kirchwehm Yvonne , Damme Alexander , Kupfer Thomas , Braunschweig Holger , Krueger Anke 
Published: May 2012

AbstractThe synthesis of sterically crowded tribenzotriquinacenes (III) with complete and partial methylation of the ortho‐positions is achieved using the double cyclodehydration strategy.
ChemInform Abstract: One‐Pot Synthesis of Pyranocoumarins via Microwave‐Assisted Pseudo Multicomponent Reactions and Their Molecular Switching Properties.
Authors: Li Kuan‐Ting , Lin Yong‐Bo , Yang Ding‐Yah 
Published: May 2012

AbstractThe optical properties of the new pyranocoumarins (IV) and (VI) are investigated.
ChemInform Abstract: Towards Chemical Libraries Based on Heterocyclic Scaffolds with Monofluorinated and Difluoroalkyl Side Chains.
Authors: Bannwarth Pierre , Gree Danielle , Das Saibal , Yadav Jhillu Singh , Gree Rene 
Published: May 2012

AbstractA small library of 26 arylhetaryl systems containing fluorinated side chains, e.g. (III) and (V), is prepared by means of Suzuki—Miyaura and Still cross coupling reactions.
ChemInform Abstract: Highly Enantioselective Synthesis of Biologically Important 2,5‐Dihydropyrroles via Phosphoric Acid Catalyzed Three‐Component Reactions and Evaluation of Their Cytotoxicity.
Authors: Shi Feng , Tao Zhong‐Lin , Yu Jie , Tu Shu‐Jiang 
Published: May 2012

AbstractSeveral of the synthesized dihydropyrroles exhibit moderate cytotoxicity towards the mammary carcinoma cell line MCF7.
ChemInform Abstract: Highly Efficient Narasaka—Heck Cyclizations Mediated by P(3,5‐(CF3)2C6H3)3: Facile Access to N‐Heterobicyclic Scaffolds.
Authors: Faulkner Adele , Bower John F. 
Published: May 2012

AbstractA facile access to perhydroindole and related scaffolds via a highly efficient Pd‐catalyzed intramolecular cyclization of oxime esters with cyclic alkenes is given.
ChemInform Abstract: Furan Ring Opening—Indole Ring Closure: Recyclization of 2‐(2‐Aminophenyl)furans into 2‐(2‐Oxoalkyl)indoles.
Authors: Pilipenko Arkady S. , Mel'chin Vladimir V. , Trushkov Igor V. , Cheshkov Dmitry A. , Butin Alexander V. 
Published: May 2012

AbstractA simple and efficient approach to the compounds (II) is presented.
ChemInform Abstract: Pd‐Catalyzed Asymmetric Hydrogenation of 3‐(Toluenesulfonamidoalkyl)indoles.
Authors: Duan Ying , Chen Mu‐Wang , Chen Qing‐An , Yu Chang‐Bin , Zhou Yong‐Gui 
Published: May 2012

AbstractA series of title compounds (III) is prepared and hydrogenated using a chiral Pd catalyst to give the 2,3‐disubstituted indolines (IV) and (V) with up to 97% e.e.
ChemInform Abstract: Highly Efficient Conversion of Carbon Dioxide Catalyzed by Polyethylene Glycol‐Functionalized Basic Ionic Liquids.
Authors: Yang Zhen‐Zhen , Zhao Ya‐Nan , He Liang‐Nian , Gao Jian , Yin Zhong‐Shu 
Published: May 2012

AbstractThe polyethylene glycol‐functionalized basic ionic liquid TBDP is found to be a highly efficient and recyclable catalyst for the synthesis of cyclic carbonates (III) via direct carboxylation of epoxides (I) without the need of any organic solvents or additives.
ChemInform Abstract: Palladium‐Catalyzed Dehalogenation of 5‐Halopyrazoles.
Authors: Chen Chun‐Yen , Huang Yu‐Ying , Su Wei‐Nien , Kaneko Kimiyoshi , Kimura Masayuki , Takayama Hiroyuki , Wong Fung‐Fuh 
Published: May 2012

AbstractA new and efficient method for the dehalogenation of 5‐halopyrazoles is developed.
ChemInform Abstract: Transformations of Enaminones. A Simple One‐Pot Synthesis of Imidazolone Derivatives.
Authors: Bezensek Jure , Groselj Uros , Stare Katarina , Svete Jurij , Stanovnik Branko 
Published: May 2012

AbstractA three‐step one‐pot synthesis of various target compounds (IV), (VI), (VIII), (X), (XII), and (XIV) is presented.
ChemInform Abstract: Synthesis and Antimicrobial Activity of Substituted [(Pyrazol‐4‐yl)methylene]hydrazono‐2,3‐dihydrothiazoles and Their Sugar Derivatives.
Authors: Abdel‐Rahman Adel A.‐H. , El‐Sayed Wael A. , Zaki El‐Sayed G. , Mohamed Asem A. , Fadda Ahmed A. 
Published: May 2012

AbstractA variety of N‐alkylated title thiazoles, e.g. (III), derivatives thereof, e.g. (IV), as well as N‐glycosyl analogues, e.g. (VI), are prepared.
ChemInform Abstract: A General Procedure for the Synthesis of Alkyl‐ and Arylethynyl‐1,2,3‐triazole‐Fused Dihydroisoquinolines.
Authors: Fiandanese Vito , Maurantonio Silvia , Punzi Angela , Rafaschieri Giacomo G. 
Published: May 2012

AbstractStarting from 2‐halophenylethyl azides, a series of click reactions with trimethylsilylacetylenes and following C—C coupling reactions leads to the title compounds.
ChemInform Abstract: Synthesis Antimicrobial and Antioxidant Activities of Some New 3‐Indolyl Pyrazolo[2,3‐c]pyran and Its Derivatives.
Authors: Saundane Anand R. , Manjunatha Yarlakatti 
Published: May 2012

AbstractThe title compounds (III) show good antimicrobial and antioxidant activities.
ChemInform Abstract: Intramolecular 1,3‐Dipolar Cycloaddition of Nitrile N‐Oxide Accompanied by Dearomatization.
Authors: Yonekawa Morio , Koyama Yasuhito , Kuwata Shigeki , Takata Toshikazu 
Published: May 2012

AbstractAn easy approach to partially dearomatized cis‐dihydrobenzoisoxazole frameworks is presented.
ChemInform Abstract: Transformation of a Hydroxyl into an Acyl Group on α‐Pyrone Ring: A Novel Route to 3,4‐Diacylcoumarins.
Authors: Kotali Antigoni , Nasiopoulou Despina A. , Harris Philip A. , Helliwell Madeleine , Joule John A. 
Published: May 2012

AbstractFor the first time, the title transformation is applied to a heterocyclic ring.
ChemInform Abstract: Facile Synthesis of 1,3,4‐Thiadiazole Appended to Coumarins as Antimicrobial Agents.
Authors: Gireesh Tegginamath , Khan Gouse Mohiddin Z. , Kamble Ravindra R. 
Published: May 2012

AbstractThe title compounds (III) are obtained from semicarbazones (I) and acetic anhydride (II) and screened for their pharmacological parameters for bioavailability.
ChemInform Abstract: Three‐Component Reactions of N‐Nucleophiles and Activated Acetylenes with NH‐Acids: A Facile Synthesis in Water.
Authors: Charati Faramarz Rostami , Hossaini Zinatossadat , Hosseini‐Tabatabaei Mohammad R. 
Published: May 2012

AbstractThe reaction is conducted under environmentally benign conditions.
ChemInform Abstract: Microwave‐Assisted Synthesis of 1,3′‐Diaza‐flavanone/flavone and Their Alkyl Derivatives with Antimicrobial Activity.
Authors: Kahriman Nuran , Iskender Nagihan Yilmaz , Yuecel Murat , Yayli Nurettin , Demir Emine , Demirbag Zihni 
Published: May 2012

AbstractA variety of N‐alkyl dihydroquinolinylpyridinium bromides, e.g. (V) and (VII), is prepared.
ChemInform Abstract: An Efficient One‐Pot Three‐Component Synthesis of Tetrahydrofuro[3,4‐b]quinoline‐1,8(3H,4H)‐dione Derivatives Catalyzed by L‐Proline.
Authors: Shi Chun‐Ling , Chen Hui , Shi Daqing 
Published: May 2012

AbstractThe reaction is conducted under environmentally benign conditions.
ChemInform Abstract: Synthesis and Biological Study of Some New Chalcones and Oxopyrimidines Containing Imidazo[1,2‐a]pyridine Nucleus.
Authors: Joshi M. J. , Vekariya P. B. , Dodiya B. L. , Ghetiya R. M. , Joshi H. S. 
Published: May 2012

AbstractThe highest activity against B.
ChemInform Abstract: Microwave‐Assisted Synthesis of 1,3‐Disubstituted β‐Carbolines from α‐(Alkylideneamino)nitriles and Gramine.
Authors: Letessier Julien , Detert Heiner , Goetz Katharina , Opatz Till 
Published: May 2012

AbstractThe title reaction produces indole derivatives of type (V) whose cyclization leads to formation of the desired alkaloid skeletons.
ChemInform Abstract: An Efficient One‐Pot Synthesis of a New Heterocyclic System.
Authors: Rahimizadeh Mohammad , Pordel Mehdi , Ranaei Mahsa , Bakavoli Mehdi 
Published: May 2012

AbstractThe nucleophilic substitution of hydrogen in a nitro derivative of imidazo[1,2‐a]pyridine (I) is used as key step in the one‐pot synthesis of a new, highly fluorescent heterocyclic system, pyridoimidazopyridoindoles (III).
ChemInform Abstract: Synthesis of 3‐Substituted and 2,3‐Disubstituted Quinazolinones via Cu‐Catalyzed Aryl Amidation.
Authors: Xu Lanting , Jiang Yongwen , Ma Dawei 
Published: May 2012

AbstractCoupling and cyclization of N‐substituted o‐bromobenzamides with formamide takes place at 80°C, whereas the other amides are converted into the target compounds via HMDS/ZnCl2‐mediated condensative cyclization.
ChemInform Abstract: Ionic Liquid Mediated One‐Pot Synthesis of 6‐Aminouracils.
Authors: Chavan Sunil S. , Degani Mariam S. 
Published: May 2012

AbstractThe novel one‐pot synthesis of title aminouracils (IV) and (VII) proceeds via tetramethylguanidinium acetate‐promoted generation of urea and cyanoacetylurea intermediates.
ChemInform Abstract: [5 + 1] Cycloaddition of C,N‐Cyclic N′‐Acyl Azomethine Imines with Isocyanides.
Authors: Soeta Takahiro , Tamura Kaname , Ukaji Yutaka 
Published: May 2012

AbstractNovel oxadiazine derivatives are constructed via a catalyst‐free reaction of azomethine imines and isocyanides.
ChemInform Abstract: Amine‐Directed Intramolecular Hydroacylation of Alkenes and Alkynes.
Authors: Bendorf Holly D. , Ruhl Kyle E. , Shurer Andrew J. , Shaffer Jennie B. , Duffin Tess O. , LaBarte Theresa L. , Maddock Michelle L. , Wheeler Oscar W. 
Published: May 2012

AbstractThe reaction offers a convenient access to medium‐sized N‐heterocycles and the process is significantly accelerated by the N‐allyl substituent.
ChemInform Abstract: Rapid Access to Pyrido[1,2,5]triazepin‐4‐ones Through Intramolecular Nucleophilic Aromatic Substitution.
Authors: Jin Shujuan , St‐Jean Olivier , Baltatu Sandra I. , Santhakumar Vijayaratnam , Tomaszewski Miroslaw J. 
Published: May 2012

AbstractThe condensation of ketoamides (I) and (IV) with methyl hydrazine produces hydrazones which undergo intramolecular nucleophilic aromatic substitution to yield the title compounds (III) and their benzo analogues (V).
ChemInform Abstract: Synthesis and Biological Activity of Novel Organoselenium Derivatives Targeting Multiple Kinases and Capable of Inhibiting Cancer Progression to Metastases.
Authors: Bijian Krikor , Zhang Zhongwei , Xu bin , Jie Su , Chen Bo , Wan Shengbiao , Wu JianHui , Jiang Tao , Alaoui‐Jamali Moulay A. 
Published: May 2012

AbstractCompound (III) exhibits a potent anti‐metastatic activity at well‐tolerated doses in an invasive human brest cancer orthotropic mouse model.
ChemInform Abstract: New Polyhydroxypregnane Glycosides from Cynanchum otophyllum
Authors: Shan Wei‐Guang , Liu Xiao , Ma Lie‐Feng , Zhan Zha‐Jun 
Published: May 2012

Abstractisolation and structural elucidation of two new pregnane glycosides, cynotophylloside G (I) and cynotophylloside H (II)
ChemInform Abstract: Pd‐Catalyzed Amidation of 2,6‐Dihalopurine Nucleosides. Replacement of Iodine at 0 °C.
Authors: Bosch Lluis , Cialicu Ionela , Caner Joaquim , Ariza Xavier , Costa Anna M. , Terrazas Montserrat , Vilarrasa Jaume 
Published: May 2012

AbstractThe replacement of halogen substituents by different N‐nucleophiles is investigated.
ChemInform Abstract: Chiral Ionic Liquids Derived from (‐)‐Ephedrine and Carbohydrates: Synthesis, Properties and Applications to Asymmetric Synthesis and Catalysis
Authors: Truong Thi‐Kim‐Thu , Van Buu Olivier Nguyen , Aupoix Audrey , Pegot Bruce , Vo‐Thanh Giang 
Published: May 2012

AbstractReview: 78 refs.
Superparamagnetic iron oxide nanoparticles conjugated to a grass pollen allergen and an optical probe
Authors: Herranz Fernando , Schmidt‐Weber Carsten B. , Shamji Mohamed H. , Narkus Annemarie , Ruiz‐Cabello Jesus , Vilar Ramon 
Published: May 2012

ABSTRACTIn this study we report the development of a bioconjugate between superparamagnetic iron oxide nanoparticles and Phl p5a (one of the major allergens from grass pollen). The bioconjugate also contains an optical probe (Alexa647) conjugated to the nanoparticle via biotin–streptavidin association. We show that this conjugate has a range of features that makes it a very promising candidate to image the localization of this allergen in vivo: (a) upon conjugation to the iron oxide nanoparticles, the allergen retains its ability to interact with IgE antibodies; (b) the magnetic properties of the iron oxide core of this bioconjugate are suitable for MR imaging; and (c) Alexa647 fluorophore retains its emission properties once attached to the iron oxide nanoparticles, yielding a dual modality MRI‐optical probe. Copyright © 2012 John Wiley & Sons, Ltd.