bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Combined Approach Using IncobotulinumtoxinA and CPM-Hyaluronic Acid Injections for the Periorbital Complex Improvement: A Pilot Study
Authors: de Sanctis Pecora Carla , Pateo Bruno Vella , Nunes Gisele Jacobino de Barros , Queiroz Abdulay Ezequiel Machado Lanna , da Silveira Bruno Rebelo Lages , Van Loghen Jani 
Published: May 2024

Abstract

Background
Previous reports have objectively demonstrated the efficacy of botulinum toxin for brow elevation. No previous clinical trial has reported a combined approach to botulinum toxin A injection with hyaluronic acid (HA) injection in the upper face for periorbital region beautification focusing on eyebrow reshaping.

Objectives
To evaluate the effect of IncobotulinumtoxinA injection using the ONE21 technique combined with HA injection (CPM technology) to redefine brow shape and position.

Methods
A prospective pilot study was designed to evaluate the effect of IncobotulinumtoxinA injection using the ONE21 technique—with a preestablished scheme of doses and injection-site distribution—combined with HA injection (CPM technology) periosteally into the palpebromalar groove and subdermally in the anterior temporal region, to redefine brow shape and position. Objective eyebrow measurements were taken by an independent investigator using the Merz Aesthetic Scale (MAS) for brow positioning. Patient satisfaction was also evaluated. Some patients were also assessed using the Vectra System (Canfield Scientific, Parsippany, NJ).

Results
Eleven females, aged 29 to 55 years, were included in this prospective pilot study. The totality of patients (11/100%) had at least ≥1-point improvement in the MAS brow positioning. All patients (100%) reported significant aesthetic improvement of their periorbital region and appearance, with 82% of the patients much improved. Mild side effects, such as ecchymosis and transient temporal edema, were reported.

Conclusions
The combined technique improved the appearance of the orbital area by uplifting the lateral eyebrow and creating an almond-shaped eye effect, which characterizes the trending marketing term Foxy eyes. Further studies, including more cases, are needed to obtain a statistically significant outcome.

Level of Evidence: 4
Biology’s transformation: from observation through experiment to computation
Authors: Ouzounis Christos A 
Published: May 2024

Abstract

Summary
We explore the nuanced temporal and epistemological distinctions among natural sciences, particularly the contrasting treatment of time and the interplay between theory and experimentation. Physics, an exemplar of mature science, relies on theoretical models for predictability and simulations. In contrast, biology, traditionally experimental, is witnessing a computational surge, with data analytics and simulations reshaping its research paradigms. Despite these strides, a unified theoretical framework in biology remains elusive. We propose that contemporary global challenges might usher in a renewed emphasis, presenting an opportunity for the establishment of a novel theoretical underpinning for the life sciences.

Availability and implementation
https://github.com/ouzounis/CLS-emerges Data in Json format, Images in PNG format.
Serum hydroxysteroid (17beta) dehydrogenase 1 concentration in pregnant women correlates with pregnancy-associated plasma protein A but does not serve as an independent marker for preeclampsia
Authors: Heinosalo Taija , Saarinen Niina , Biehl Alexander , Rytkönen Kalle T , Villa Pia M , Juhila Juuso , Koskimies Pasi , Laiho Asta , Hämäläinen Esa , Kajantie Eero , Räikkönen Katri , Elo Laura L , Laivuori Hannele , Poutanen Matti 
Published: May 2024

Abstract
Hydroxysteroid (17beta) dehydrogenase 1 (HSD17B1) is a steroid synthetic enzyme expressed in ovarian granulosa cells and placental syncytiotrophoblasts. Here, HSD17B1 serum concentration was measured with a validated immunoassay during pregnancy at three time points (12–14, 18–20 and 26–28 weeks of gestation). The concentration increased 2.5-fold (P &lt; 0.0001) and 1.7-fold (P = 0.0019) during the follow-up period for control women and women who later developed preeclampsia (PE), respectively, and a significant difference was observed at weeks 26–28 (P = 0.0266). HSD17B1 concentration at all the three time points positively correlated with serum PAPPA measured at the first time point (first time point r = 0.38, P = 1.1 × 10−10; second time point r = 0.27, P = 5.9 × 10−6 and third timepoint r = 0.26, P = 2.3 × 10−5). No correlation was observed between HSD17B1 and placental growth factor (PLGF). Serum HSD17B1 negatively correlated with the mother’s weight and body mass index (BMI), mirroring the pattern observed for PAPPA. The univariable logistic regression identified a weak association between HSD17B1 at 26–28 weeks and later development of PE (P = 0.04). The best multivariable model obtained using penalized logistic regression with stable iterative variable selection at 26–28 weeks included HSD17B1, together with PLGF, PAPPA and mother’s BMI. While the area under the receiver operating characteristic curve of the model was higher than that of the adjusted PLGF, the difference was not statistically significant. In summary, the serum concentration of HSD17B1 correlated with PAPPA, another protein expressed in syncytiotrophoblasts, and with mother’s weight and BMI but could not be considered as an independent marker for PE.
111 UTILIZATION OF ARTIFICIAL INTELLIGENCE IN MINIMALLY INVASIVE RIGHT ADRENALECTOMY: RECOGNITION OF ANATOMICAL LANDMARKS WITH DEEP LEARNING
Authors: Sengun B , Iscan Y , Yazici Z A , Cem Sormaz I , Aksakal N , Tunca F , Ekenel Hazim Kemal , Senyurek Y G 
Published: May 2024

Abstract

Background
The primary surgical approach for removing adrenal masses is minimally invasive adrenalectomy. Recognition of anatomical landmarks during surgery is critical for minimizing complications. Artificial intelligence-based tools can be utilized to create real-time surgical navigation systems.

Methods
In this experimental feasibility study, intraoperative videos of 20 patients who underwent minimally invasive right adrenalectomy in a tertiary care center between 2011 and 2023 were analyzed and used to develop an artificial intelligence-based anatomical landmark recognition system. Semantic segmentation of the liver, the inferior vena cava (IVC), and the right adrenal gland was performed. Fifty random images per patient during the dissection phase were extracted. The experiments on the annotated images were performed on two state-of-the-art segmentation models named U-Net and SwinUNETR. The dataset was split into training and validation subsets with an 80:20 distribution. The models were trained with the Dice-Cross Entropy loss function, and the dice similarity coefficient (DSC) was calculated for the predictions on the validation subset.

Results
Out of 20 videos, 1000 images were extracted, and anatomical landmarks (liver, IVC, and right adrenal gland) were annotated. Randomly distributed 800 and 200 images were selected for the training and the validation subsets, respectively. Our benchmark results show that the transformer-based SwinUNETR model achieved 78.37%, and the U-Net model with the EfficientNet-0 backbone achieved 77.95% DSC scores on a three-region prediction task.

Conclusions
Artificial intelligence-based systems can predict anatomical landmarks with high performance in minimally invasive right adrenalectomy. Such tools can be used to create real-time navigation systems during surgery in the near future.
316 HALF OF THE PATIENTS WITH CLINICALLY UNIFOCAL T1B/SMALL T2 NODE NEGATIVE PAPILLARY THYROID CARCINOMA SCHEDULED FOR THYROID LOBECTOMY MAY REQUIRE COMPLETION THYROIDECTOMY IF THE NODAL STATUS IS EVALUATED
Authors: Laurino A , Pennestrì F , Martullo A , Gallucci P , Prioli F , Sessa L , Rossi E D , De Crea C , Raffaelli M 
Published: May 2024

Abstract

Background
Thyroid lobectomy (TL) should be preferred over total thyroidectomy (TT) for small unifocal, papillary thyroid carcinoma (PTC), in the absence of aggressive features. Despite prophylactic central neck dissection is not usually recommended, occult, non-microscopic (&gt;2 mm), nodal metastases (ONM) may occur in clinically node-negative (cN0) PTC, increasing the risk of recurrence.

Methods
Among 4216 patients operated for thyroid malignancies (January 2014-Nomber 2023), 110 (2.6%) with unifocal cT1b/small cT2 (&lt;3 cm) cN0 PTCs were scheduled for TL plus ipsilateral central neck dissection (I-CND). Completion thyroidectomy (CT) was accomplished during the same procedure when frozen section examination (FSE) of removed nodes showed ONM and within 6 months in case of aggressive pathologic features at final pathology.

Results
There were 102 (92.7%) cT1b and 8 (7.3%) cT2 PTC. FSE was positive for ONM in 33 (30%) cases, requiring immediate CT. Median number of removed and metastatic nodes at definitive pathology were 12 and 5, respectively. Multifocality was present in 25 (75.7%) cases, angioinvasion in 25 (75.7%), aggressive variants in 9 (27.3%) and extracapsular extension in 1 (3.0%). Among the remaining 77 patients, 24 (31.2%) were subsequently scheduled for CT, due to ONM/aggressive histopathological features. Overall, 57 (51.8%) patients underwent immediate or delayed CT.

Conclusions
Half of unifocal cT1b/small cT2 (1-3 cm) cN0 PTC scheduled for TL required CT because of ONM/aggressive features. I-CND and FSE evaluation of the removed nodes allow to intraoperatively modulate the extension of resection, ensuring accurate staging and reducing the risk of recurrence and the need for reoperation.
26 TALKING THE TALK AND POSTING THE PAPERS: UNVEILING PUBLISHING PATTERNS IN ESES CONGRESS ABSTRACTS
Authors: Schneider M , Dukaczewska A , van Beek D J , Van den Heede K , Sharma G , Almquist Martin 
Published: May 2024

Abstract

Background
The biannual congresses of the European Society of Endocrine Surgeons (ESES) have been a valuable platform for presenting research since 2004. However, the publication rate of abstracts presented at ESES congresses is unknown.

Methods
We searched for full publications using titles and authors of abstracts presented orally or as posters at ESES congresses from 2004 to 2018. Abstract factors, such as type of study and number of patients, were investigated in relation to publication rate, journal impact factor, and citation rates of published studies.

Results
Out of 733 abstracts presented at ESES during this period, 207 (28%) were presented orally and 528 (72%) as a poster. The median number of patients included per study was 72 [1-22,580]. Overall, 456 of the abstracts (62%) were published, with a median time of 11.4 months from the ESES congress to publication [range -64.5 - 156]. The median number of citations per published abstract was 21 [range 0-821], the average annual citation rate was 2.3 [0-54], and the median journal impact factor was 2.2 [0-21.3]. Abstracts that were published were more often presented orally and were more often prospective.

Conclusions
While the publication rates of ESES congress abstracts are high, studies involved a limited number of patients. Collaborative efforts to include more patients in prospective studies could increase the publication rate of abstracts and enhance the overall scientific impact of the ESES congresses.
99 THE USE OF THYROID CARTILAGE NEEDLE ELECTRODES DURING INTRAOPERATIVE NERVE MONITORING IN THYROID SURGERY: A MULTI-CENTER RETROSPECTIVE STUDY
Authors: Balci K , Turk Y , Ozdemir M , Kuczma P , Trésallet C , Wu C W , Huang T Y , Muhammed A S , Muhammad R , Niza S , Harlina N , Buzejic M , Zivaljevic V , Jovanovic M , Makay Ö 
Published: May 2024

Abstract

Background
In previous studies, the use of thyroid cartilage needle electrodes (TCN) was defined as an inexpensive method for intraoperative nerve monitoring (IONM) in thyroid surgery. This multicenter retrospective study aims to determine the effectiveness and reliability of TCN in thyroid surgery.

Methods
Patients operated on between January 2018 and August 2023 from five centers in five countries and two continents were included in this study. Demographic data, indications, type of surgery, IONM recording system, pre-post resection vagus nerve(V1-V2), pre-post resection recurrent laryngeal nerve(R1-R2) amplitudes and latency values, type of loss of signal(LOS), adverse event(AE), intraoperative injury mechanism, postoperative vocal cord examination(VCE) were evaluated. Patients with abnormal preoperative vocal cord examination were excluded.

Results
A total of 2105 patients (3772 nerves at risk) were included [1626 (77.3%) female, 479 (22.7%) males]; within this study, 1112 patients (52.8%) received a diagnosis of malignancy, while 993 (47.2%) were diagnosed with benign conditions. The mean initial vagus amplitude was 1093.74 µV(±861.39). LOS occurred in 57 patients [Type 1 (91.2%), Type 2 (8.8%)] and AE in 36. No false positive LOS occurred. Forty-five(86.5%) of LOS type-1 patients and 4 (80%) of LOS type-2 patients had vocal cord palsy (VCP) during VCE (p&lt; 0.05). In AE patients, there were only two (5.5%) patients who had VCP during VCE (p&lt;0.05). VCP occurred in 34(1.6%) patients, with 9 (0.42%) remaining permanent.

Conclusions
TCN is an inexpensive and feasible alternative to endotracheal tube electrodes and a system with satisfying amplitudes. It can also precisely predict post-operative vocal cord functions.
Threshold Decisions in Social Work: Using Theory to Support Practice
Authors: Turney Danielle , Alfandari Ravit , Taylor Brian J , Ghanem Christian , Helm Duncan , Killick Campbell , Lyons Olive , O’Leary Donna , Ebsen Frank , Bertotti Teresa 
Published: May 2024

Abstract
Decision making is an intrinsic and complex aspect of social work practice, requiring consideration of diverse but connected aspects. Decisions are often required as to whether a situation requires protective state intervention or whether it reaches the criteria for public or charitable services. Such instances of deciding whether or not a situation is ‘on one side of the line or the other’ are referred to in this article as ‘threshold judgements’. This article draws on experiences and material from a range of social work contexts to explore generalisable theory-informed understandings of ‘threshold judgements’ and ‘threshold decisions’ to develop knowledge and skills on this topic. The article outlines signal detection theory and evidence accumulation (‘tipping point’) theory and discusses these as ways to understand the key concepts underpinning threshold decisions in social work. We then argue that although these threshold concepts are a necessary part of decision making in social work, as in many other aspects of life, they are not sufficient. Operationalising such decisions requires some form of sense-making. Naturalistic decision making and heuristic models of judgement are discussed as frameworks for practice which seem to be useful in this context.
The struggle for land by indigenous groups: from conflict to cooperation in Kasepuhan Ciptagelar, Indonesia
Authors: Sutiyo Sutiyo 
Published: May 2024

Abstract
This study discusses the perspective of a positive-sum game in land conflicts involving indigenous groups. It is based on a case study using qualitative methods in the Kasepuhan Ciptagelar, an indigenous group in Indonesia. Findings show the perspective enables collaborative resource management for conflict resolution. Semi-legal agreements reduce uncertainty, prevent violence, and provide opportunities for the group to earn livelihoods along with forest conservation. These are enabled by the principle of mutual respect as the rule in use by all parties. Certain limitations are still associated with the outcomes, which indicate the need for a more equitable, written, and permanent settlement. Decentralizing conflict resolution to the local level can lead to innovative solutions if the interactions among all actors are based on the principle of mutual respect and a commitment to prevent violence.
A framework for tourism value chain ownership in rural communities
Authors: Chambwe Michael , Saayman Andrea 
Published: May 2024

Abstract
Tourism is prevalent in rural areas of South Africa, where natural settings provide attractive opportunities. Despite tourism’s potential to improve societies, many surrounding rural populations struggle with poverty. They have low involvement in tourism activity and need more access to empowerment programmes, and there need to be community-based structures that encourage equitable tourism engagement. This conceptual paper presents a framework for action designed for rural communities’ participation in a business or earning capacity in the local area’s tourism potential. The framework draws on published secondary data sources related to community-based tourism, community involvement, and potential rural community ownership of the tourism value chain. The literature is used to inform the development of our tourism value chain ownership framework, which can be applied in rural communities for poverty reduction and community empowerment.
Zirconium-based metal-organic framework with bis(hydroxyphenyl)anthracene derivative: molecular design, synthesis, crystal structures, and methane adsorption
Authors: Ohmura Tetsushi , Hosokawa Yoichi , Motegi Hirofumi , Mukae Yusuke , Senda Shunsuke , Matsumoto Tsuyoshi , Tatsumi Kazuyuki , Shichi Akira , Nakamura Hiroshi , Usuki Arimitsu 
Published: May 2024

Abstract
A metal-organic framework (MOF) composed of a zirconium cluster with a bis(hydroxyphenyl)anthracene linker, Zr6O4(OH)4(adhb)6 (adhb: 4,4′-(anthracene-9,10-diyl)bis(2-hydroxybenzoic acid), was designed to achieve methane storage up to 300 g and batch synthesized without using an autoclave. This MOF can adsorb 65.4 cm3STP/cm3 and 4.7w% of methane at 294 K and 9.8 bar due to its large specific surface area of 1,818 m2/g and void fraction of 0.78 cm3/g. Furthermore, an octahedral cage model indicated that the anthracene ring provides a suitable pore entrance and steric hindrance for methane inclusion.
Acclimation of thermal tolerance in juvenile plants from three biomes is suppressed when extremes co-occur
Authors: Harris Rosalie J , Alvarez Philippa R , Bryant Callum , Briceño Verónica F , Cook Alicia M , Leigh Andrea , Nicotra Adrienne B 
Published: May 2024

Abstract
Given the rising frequency of thermal extremes (heatwaves and cold snaps) due to climate change, comprehending how a plant’s origin affects its thermal tolerance breadth (TTB) becomes vital. We studied juvenile plants from three biomes: temperate coastal rainforest, desert and alpine. In controlled settings, plants underwent hot days and cold nights in a factorial design to examine thermal tolerance acclimation. We assessed thermal thresholds (Tcrit-hot and Tcrit-cold) and TTB. We hypothesized that (i) desert species would show the highest heat tolerance, alpine species the greatest cold tolerance and temperate species intermediate tolerance; (ii) all species would increase heat tolerance after hot days and cold tolerance after cold nights; (iii) combined exposure would broaden TTB more than individual conditions, especially in desert and alpine species. We found that biome responses were minor compared to the responses to the extreme temperature treatments. All plants increased thermal tolerance in response to hot 40°C days (Tcrit-hot increased by ~3.5°C), but there was minimal change in Tcrit-cold in response to the cold −2°C nights. In contrast, when exposed to both hot days and cold nights, on average, plants exhibited an antagonistic response in TTB, where cold tolerance decreased and heat tolerance was reduced, and so we did not see the bi-directional expansion we hypothesized. There was, however, considerable variation among species in these responses. As climate change intensifies, plant communities, especially in transitional seasons, will regularly face such temperature swings. Our results shed light on potential plant responses under these extremes, emphasizing the need for deeper species-specific thermal acclimation insights, ultimately guiding conservation efforts.
A Call to Action: Unifying School Social Work Practice Models
Authors: Lucio Robert , Souhrada Emilie , Shayman Emily , Michalczak Hannah 
Published: May 2024

Abstract
School social work (SSW) roles are often surrounded by ambiguity across schools, districts, states, and nationally. The School Social Work Association of America’s National Practice Model and National Evaluation Framework, along with the National Association of Social Workers’ Standards for School Social Work Services are the guidance provided at the national level for practitioners and scholars alike. This study examined each of these pieces to thoroughly understand existing critical components of SSW practice. Comparing and analyzing these critical components across all three resources through systematic content analysis led to findings that illuminate the limited shared components. This call for action—to unify SSW practice models and frameworks in a way to prescribe justice-oriented work—comes from these findings, which indicate that current national-level resources are disjointed, incohesive, and lack focus on diversity, equity, and inclusion practices, which are the foundational values of the social work profession. A unified framework would not only represent the current challenges and needs of SSW practitioners, but would also help establish clear roles, responsibilities, and boundaries for SSW practice.
Environmental impact of dietary patterns in 10 European countries; a cross-sectional analysis of nationally representative dietary surveys
Authors: Alves Ricardo , Perelman Julian , Chang Kiara , Millett Christopher 
Published: May 2024

Abstract

Background
Changing dietary patterns is essential to reducing the substantial environment impact of agriculture and food production systems. We performed a cross-country comparison of dietary patterns and their associated environmental impact in Europe, including by sociodemographic factors.

Methods
We analyzed pooled cross-sectional dietary records collected during 2010–18 from 10 European countries using the European Food Safety Authority (EFSA) Comprehensive European Food Database (16 508 adults; aged 18–79 years). Each food consumed was mapped to the corresponding environmental impact data using the SHARP Indicators Database, which provides greenhouse gas emission (GHGE) and land use (LU) values of approximately 900 foods. Total diet-associated environmental impact was calculated for each person and averaged across multiple days. Multivariable linear regression models were used to compare diet-associated GHGE and LU between population subgroups (gender, age, education and diet type) with country-level fixed effects.

Results
The mean dietary GHGE and LU per capita ranged from 4.0 kgCO2/day and 5.0 m2*year/day in Spain to 6.5 kgCO2eq/day and 8.2 m2*year/day in France. Diet-related GHGE and LU (per kg/food) were lower among females (2.6 kgCO2eq/day, B = −0.08, P &lt; 0.01; 3.2 m2*year/day, B = −0.11, P &lt; 0.01), older population aged 66–79 (2.6 kgCO2eq/day, B = −0.03, P &lt; 0.01; 3.4 m2*year/day, B = −0.4, P &lt; 0.01), people following vegetarian diets (1.7 kgCO2eq/day, B = −0.07, P &lt; 0.01; 2.0 m2*year/day, B = −0.07, P &lt; 0.01), and higher among individuals with secondary education (2.7 kgCO2eq/day, B = 0.05, P &lt; 0.01; 3.6 m2*year/day, B = −0.05, P &lt; 0.01).

Conclusions
Environmental footprints vary substantially across countries, dietary patterns and between different sociodemographic groups in Europe. These findings are crucial for the development of country-specific food policies aimed at promoting environmentally sustainable diets.