bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of gynecologic cancer on female sexuality in Europe and MENA (Middle East and North Africa): a literature review
Authors: Shams Malihe , Coman Claudia , Fatone Fabiola , Marenesi Vittoria , Bernorio Roberto , Feltrin Alessandra , Groff Elena 
Published: June 2024

Abstract

Introduction
Gynecologic cancer has a negative impact on the sexuality of women who are or have been affected by this disease. In fact, gynecologic cancers cause negative changes in female sexuality, affecting body image and psychophysical well-being, with serious consequences for women’s sex lives.

Objectives
The aim of this study is to analyze the differences in sexuality among women who have or have had gynecologic cancer in Europe and in the Middle East and North Africa (MENA). We also explored possible factors that may influence women’s sexuality in the 2 populations compared.

Methods
The literature search was carried out using PubMed and Google Scholar, considering the 10-year period of 2013 to 2023. Studies were initially selected according to the criterion that the title and abstract were in English. We then reviewed all the articles selected in the first phase and analyzed the following information: author, year of publication, type of gynecologic cancer, country in which the study was conducted, design, and materials used. Finally, we defined the inclusion criteria for the present paper: women 18 years of age or older, diagnosed with gynecologic cancer, and who had undergone treatment (surgery, chemotherapy, radiotherapy). The studies reviewed were conducted between 2013 and 2023 in Europe and MENA, and all analyzed sexual function after the disease, understood as a general dimension that includes physiological and psychological aspects.

Results
The results of this research show that patients in both geographical areas (Europe and MENA) report changes in sexuality as a result of the cancer. Studies show that cancer reduces, interrupts, and impairs women’s sexual activity, resulting in experiences of discomfort, anxiety, guilt, inadequacy, pain, and poorer quality of life.

Conclusions
The data analyzed in this review show that cancer causes changes and deterioration in sexuality in both populations studied. No cultural or social factors were found to cause differences between the variables studied in the 2 populations. In the future, it may be interesting to carry out further studies to improve the treatment of women with gynecologic cancer, as sexuality is a very important part of a person’s life.
TRPV4 mediates IL‐1‐induced Ca2+ signaling, ERK activation and MMP expression
Authors: Wang Qin , Ji Chenfan , Ali Aiman , Ding Isabel , Wang Yongqiang , McCulloch Christopher A. 
Published: June 2024

AbstractCa2+ permeation through TRPV4 in fibroblasts is associated with pathological matrix degradation. In human gingival fibroblasts, IL‐1β binding to its signaling receptor (IL‐1R1) induces activation of extracellular regulated kinase (ERK) and MMP1 expression, processes that require Ca2+ flux across the plasma membrane. It is not known how IL‐1R1, which does not conduct Ca2+, generates Ca2+ signals in response to IL‐1. We examined whether TRPV4 mediates the Ca2+ fluxes required for ERK signaling in IL‐1 stimulated gingival fibroblasts. TRPV4 was immunostained in fibroblasts of human gingival connective tissue and in focal adhesions of cultured mouse gingival fibroblasts. Human gingival fibroblasts treated with IL‐1β showed no change of TRPV4 expression but there was increased MMP1 expression. In mouse, gingival fibroblasts expressing TRPV4, IL‐1 strongly increased [Ca2+]i. Pre‐incubation of cells with IL‐1 Receptor Antagonist blocked Ca2+ entry induced by IL‐1 or the TRPV4 agonist GSK101. Knockout of TRPV4 or expression of a non‐Ca2+‐conducting TRPV4 pore‐mutant or pre‐incubation with the TRPV4 inhibitor RN1734, blocked IL‐1‐induced Ca2+ transients and expression of the mouse interstitial collagenase, MMP13. Treatment of mouse gingival fibroblasts with GSK101 phenocopied Ca2+ and ERK responses induced by IL‐1; these responses were absent in TRPV4‐null cells or cells expressing a non‐conducting TRPV4 pore‐mutant. Immunostained IL‐1R1 localized with TRPV4 in adhesions within cell extensions. While TRPV4 immunoprecipitates analyzed by mass spectrometry showed no association with IL‐1R1, TRPV4 associated with Src‐related proteins and Src co‐immunoprecipitated with TRPV4. Src inhibition reduced IL‐1‐induced Ca2+ responses. The functional linkage of TRPV4 with IL‐1R1 expands its repertoire of innate immune signaling processes by mediating IL‐1‐driven Ca2+ responses that drive matrix remodeling in fibroblasts. Thus, inhibiting TRPV4 activity may provide a new pharmacological approach for blunting matrix degradation in inflammatory diseases.
Association of embryonic inositol status with susceptibility to neural tube defects, metabolite profile, and maternal inositol intake
Authors: Leung Kit‐Yi , Weston Eleanor , De Castro Sandra C. P. , Nikolopoulou Evanthia , Sudiwala Sonia , Savery Dawn , Eaton Simon , Copp Andrew J. , Greene Nicholas D. E. 
Published: June 2024

AbstractMaternal nutrition contributes to gene–environment interactions that influence susceptibility to common congenital anomalies such as neural tube defects (NTDs). Supplemental myo‐inositol (MI) can prevent NTDs in some mouse models and shows potential for prevention of human NTDs. We investigated effects of maternal MI intake on embryonic MI status and metabolism in curly tail mice, which are genetically predisposed to NTDs that are inositol‐responsive but folic acid resistant. Dietary MI deficiency caused diminished MI in maternal plasma and embryos, showing that de novo synthesis is insufficient to maintain MI levels in either adult or embryonic mice. Under normal maternal dietary conditions, curly tail embryos that developed cranial NTDs had significantly lower MI content than unaffected embryos, revealing an association between diminished MI status and failure of cranial neurulation. Expression of inositol‐3‐phosphate synthase 1, required for inositol biosynthesis, was less abundant in the cranial neural tube than at other axial levels. Supplemental MI or d‐chiro‐inositol (DCI) have previously been found to prevent NTDs in curly tail embryos. Here, we investigated the metabolic effects of MI and DCI treatments by mass spectrometry‐based metabolome analysis. Among inositol‐responsive metabolites, we noted a disproportionate effect on nucleotides, especially purines. We also found altered proportions of 5‐methyltetrahydrolate and tetrahydrofolate in MI‐treated embryos suggesting altered folate metabolism. Treatment with nucleotides or the one‐carbon donor formate has also been found to prevent NTDs in curly tail embryos. Together, these findings suggest that the protective effect of inositol may be mediated through the enhanced supply of nucleotides during neural tube closure.
Comparison of Patients Operated for Lumbar Spinal Stenosis With and Without Spondylolisthesis​​​​​
Authors: Weber Clemens , Hermansen Erland , Myklebust Tor Åge , Banitalebi Hasan , Brisby Helena , Brox Jens I. , Franssen Eric , Hellum Christian , Indrekvam Kari , Harboe Knut , Rekeland Frode , Solberg Tore , Storheim Kjersti , Austevoll Ivar M. 
Published: June 2024

Study Design.
Observational cohort study (secondary analysis of two randomized trials).

Objective.
The aim of this study was to investigate whether function, disability, pain, and quality of life before surgery and patient-reported outcome as well as complication and reoperation rates up to 2 years after surgery differ between lumbar spinal stenosis patients with and without spondylolisthesis.

Summary of Background Data.
Lumbar spinal stenosis is a degenerative condition of the spine, which appears with or without degenerative spondylolisthesis often presenting similar signs and symptoms.

Materials and Methods.
This study is a secondary analysis of two randomized trials on patients with lumbar spinal stenosis with and without spondylolisthesis conducted at 16 public Norwegian hospitals. Disability, function, back pain, leg pain, quality of life, complication, and reoperation rates up to 2 years after surgery were compared between the two cohorts.

Results.
A total of 704 patients were included in this study, 267 patients with spondylolisthesis [median age: 67.0 yr (IQR: 61.0–72.0 yr); 68.7% female] and 437 patients without spondylolisthesis [median age: 68.0 yr (IQR: 62.0–73.0 yr); 52.9% female]. In the linear mixed-model analysis there were no significant differences in disability, function, back pain, leg pain, and quality of life scores between the two cohorts of patient with and without spondylolisthesis before surgery or at 2 years of follow-up. The complication rate was 22.9% in patients with spondylolisthesis and 12.1% in patients without spondylolisthesis (P<0.001). There were no significant differences in reoperation rates.

Conclusions.
In patients with lumbar spinal stenosis the symptom burden before surgery and the clinical outcome up to 2 years after surgery were similar independently of a concomitant spondylolisthesis.

Level of Evidence.
II.
One-Hour Suicide Prevention Training Makes a Difference!
Authors: Lyon Nour R. , Thomas Robi , Kwasky Andrea N. 
Published: June 2024

ABSTRACT:
Nurses and other healthcare workers in the United States are at increased risk of suicide compared to non-healthcare workers. College students also experience high suicide risk. To impact suicide prevention in these populations, a Question, Persuade, Refer (QPR) 1-hour gatekeeper suicide prevention training program was implemented at the University of Detroit Mercy for faculty, staff, and administrators in the College of Health Professions (N = 43). Knowledge in seven areas of suicide significantly increased after the training (p < .001). Sixteen attitudes about suicide improved; however, only two showed a statistically significant change. Results support that 1-hour QPR training can be effectively implemented in a large organization.
Jumps and Plyometric Exercises in the Return to Play After Sports Injuries
Authors: Arias-Vázquez Pedro Iván , Quezada-González Héctor Ricardo , Loeza-Magaña Pavel , Castillo-Ávila Rosa Giannina , Hernández-Gil Karen del Carmen , Poblete-Magaña Jesus 
Published: June 2024

Background:
Jumps and plyometric exercises represent a fundamental component of high-intensity sports activities and must be included in the return to play programs after a sports injury. However, the scientific literature focused on the prescription methodology of these activities in the return to play programs is limited.

Objective:
The aim of this manuscript was to provide an overview of the aspects related to the incorporation of jumps and plyometric exercises in the return to play programs.

Results:
Some clinical criteria that the athlete must meet to be incorporated into jump work and plyometric exercises in return to play programs are capacity of the injured tissue to support the load, absence of symptoms, complete joint mobility, previous acquisition of basic motor patterns of the lower limbs, adequate level of strength and muscular balance and technically consolidated jump gesture. The methodological prescription of jumps and plyometric exercises in return to play programs must consider variables such as the type of jumps, intensity, volume, and execution surface, to guarantee adequate progression and minimize the risk of injury recurrence.

Conclusions:
Jumps and plyometric exercises are frequently included in intermediate and advanced phases of return to play programs but the information on their prescription in this area is scarce; we establish a methodological guide that can be useful for the prescription of jumps and plyometric exercises in return to play programs, based mainly on biomechanical studies that evaluate various aspects of the joint load during its execution.
Act or Wait? Presentation Delay in Symptomatic Breast Cancer in China
Authors: An Jinghua , Steffen Alana D. , Collins Eileen G. , Molina Yamilé , Li Xiaomei , Ferrans Carol E. 
Published: June 2024

BackgroundIn Western countries, factors contributing to breast cancer presentation delay have been identified, but little is known about presentation delay in China, where culture and healthcare systems are quite different.ObjectiveTo describe the delay interval among newly diagnosed breast cancer patients in China and to identify factors influencing delay, including the COVID-19 pandemic.MethodsUsing a cross-sectional design, we recruited 154 participants within 3 months of pathological diagnosis of breast cancer. Data were collected using standardized scales and open-ended questions.ResultsWe found 44.8% of participants delayed ≥1 month, and 24.7% delayed ≥3 months before presentation, after self-discovery of symptoms. Logistic regression analysis showed that factors associated with longer delay (≥1 month) included preferring female physicians for breast examination, fewer negative emotions (afraid, anxious, distressed) regarding breast symptoms, more competing priorities, believing folk therapy can help treat lumps, and visiting a secondary or tertiary hospital instead of primary healthcare providers (P< .05 for all). Interaction tests showed perceived seriousness of symptoms significantly predicted delay of ≥1 month only when perceived healthcare access or trust in physicians was low. Patients (14%) reported delaying due to fear of COVID-19 infection and inability to leave home.ConclusionsPresentation delays were substantial and multilevel barriers to timely presentation were identified, which would be expected to contribute to later-stage cancer at diagnosis.Implications for practiceFindings suggest that nursing interventions and improved health policies are urgently needed in China, including breast cancer education to increase awareness.
Extended and Long-term Cancer Survivorship of Childhood Survivors
Authors: Leite Ana Carolina Andrade Biaggi , Nascimento Lucila Castanheira , Neris Rhyquelle Rhibna , Soto-Ruiz Nelia , Escalada-Hernández Paula , Martín-Rodríguez Leticia San , García-Vivar Cristina 
Published: June 2024

Background
With the increasing survival rates of childhood cancer, nurses’ familiarity with published evidence has become crucial to care for this population and their families throughout the survival process.

Objective
To systematically identify and conduct a bibliometric analysis of nursing-related evidence concerning extended and long-term survival of childhood survivors.

Methods
A scoping review was conducted using bibliometric analysis with searches performed in the PubMed, CINAHL, SCOPUS, and Web of Science databases. A total of 300 studies on childhood cancer survival within the nursing field were included.

Results
The first study on this topic was published in 1975. American and Chinese researchers lead study publications, primarily publishing in nursing journals such as Cancer Nursing. Quantitative designs were prevalent, and the majority of the studies focused on physical late effects, overall quality of life, and survivor follow-up care.

Conclusions
This study has allowed us to map and synthesize the bibliometric evidence pertaining to the extended and long-term survivorship of childhood cancer survivors in the nursing field. Consequently, it identifies gaps in knowledge, research trends, and areas necessitating further exploration.

Implications for Practice
The evidence presented in this review can facilitate academic and clinical discussions, offering a comprehensive synthesis of the published knowledge. More research needs to be developed on the topic, particularly in Central and Latin America, Africa, Southern and Eastern Europe, and in some regions of Asia. Furthermore, the scope of studies should extend beyond late effects and quality of life, encompassing the experience of surviving childhood cancer, including psychosocial and spiritual dimensions.
Dispelling the Myths of Isotretinoin and Implications for Rhinoplasty
Authors: Blough Jordan T. , Rohrich Rachel , Wyles Saranya P. , Rohrich Rodney J. 
Published: June 2024

Summary:
Despite concerns from 1980s case reports, oral isotretinoin, a derivative of Vitamin A, has largely proven to be safe in surgical procedures with the exception of deep skin resurfacing. Isotretinoin modulates thinning skin and internal scarring in select rhinoplasty patients who may otherwise have poor definition and excessive scarring. A review of patients undergoing surgical interventions including rhinoplasty in the setting of concomitant isotretinoin was performed to examine safety and therapeutic potential. Forty-nine studies were reviewed. Isotretinoin use appears to be safe in a wide variety of surgical procedures relying on internal scar formation. In rhinoplasty, studies utilized oral isotretinoin to thin skin and improve appearance, patient and surgeon satisfaction. As such, the clinical potential for using oral isotretinoin in select rhinoplasty candidates such as those with thick glaborous sebaceous skin, ethnic, male, and/or revision patients, could mitigate internal scarring processes. Further studies examining the optimal dosing regimen and long-term benefits are warranted.
Modeling the HIV cascade of care using routinely collected clinical data to guide programmatic interventions and policy decisions
Authors: Bakoyannis Giorgos , Elul Batya , Wools-Kaloustian Kara K. , Brown Steven , Semeere Aggrey , Castelnuovo Barbara , Diero Lameck , Nakigozi Gertrude , Lyamuya Rita , Yiannoutsos Constantin T. ,   for the East Africa IeDEA Regional Consortium
Published: June 2024

Background:
The HIV care cascade is a framework to examine effectiveness of HIV programs and progress toward global targets to end the epidemic but has been conceptualized as a unidirectional process that ignores cyclical care patterns. We present a dynamic cascade that accounts for patient “churn,” and apply novel analytic techniques to readily available clinical data to robustly estimate program outcomes and efficiently assess progress towards global targets.

Methods:
Data were assessed for 35,649 people living with HIV and receiving care at 78 clinics in East Africa between 2014-2020. Patients were aged >15 years and had >1 viral load measurements. We used multi-state models to estimate the probability of being in 1 of 5 states of a dynamic HIV cascade: (1) in HIV care but not on antiretroviral therapy (ART); (2) on ART; (3) virally suppressed; (4) in a gap-in-care; and (5) deceased; and compared these among subgroups. To assess progress towards global targets, we summed those probabilities across patients and generated population-level proportions of patients on ART and virally suppressed in mid-2020.

Results:
One year following enrollment, 2.8% of patients had not initiated ART, 86.7% were receiving ART, 57.4% were virally suppressed,10.2% were disengaged from care, and 0.3% had died. At 5 years, the proportion on ART remained steady but viral suppression increased to 77.2%. Of those aged 15-25, >20% had disengaged from care and <60% were virally suppressed. In mid-2020, 90.1% of the cohort was on ART, 90.7% of whom had suppressed virus.

Conclusion:
Novel analytic approaches can characterize patient movement through a dynamic HIV cascade and, importantly, by capitalizing on readily available data from clinical cohorts, offer an efficient approach to estimate population-level proportions of patients on ART and virally suppressed. Significant progress towards global targets was observed in our cohort but challenges remain among younger patients.
Deep Learning Reconstructed New-Generation 0.55 T MRI of the Knee—A Prospective Comparison With Conventional 3 T MRI
Authors: Donners Ricardo , Vosshenrich Jan , Segeroth Martin , Seng Magdalena , Fenchel Matthias , Nickel Marcel Dominik , Bach Michael , Schmaranzer Florian , Todorski Inga , Obmann Markus M. , Harder Dorothee , Breit Hanns-Christian 
Published: June 2024

Objectives
The aim of this study was to compare deep learning reconstructed (DLR) 0.55 T magnetic resonance imaging (MRI) quality, identification, and grading of structural anomalies and reader confidence levels with conventional 3 T knee MRI in patients with knee pain following trauma.

Materials and Methods
This prospective study of 26 symptomatic patients (5 women) includes 52 paired DLR 0.55 T and conventional 3 T MRI examinations obtained in 1 setting. A novel, commercially available DLR algorithm was employed for 0.55 T image reconstruction. Four board-certified radiologists reviewed all images independently and graded image quality, noted structural anomalies and their respective reporting confidence levels for the presence or absence, as well as grading of bone, cartilage, meniscus, ligament, and tendon lesions. Image quality and reader confidence levels were compared (P < 0.05, significant), and MRI findings were correlated between 0.55 T and 3 T MRI using Cohen kappa (κ).

Results
In reader's consensus, good image quality was found for DLR 0.55 T MRI and 3 T MRI (3.8 vs 4.1/5 points, P = 0.06). There was near-perfect agreement between 0.55 T DLR and 3 T MRI regarding the identification of structural anomalies for all readers (each κ ≥ 0.80). Substantial to near-perfection agreement between 0.55 T and 3 T MRI was reported for grading of cartilage (κ = 0.65–0.86) and meniscus lesions (κ = 0.71–1.0). High confidence levels were found for all readers for DLR 0.55 T and 3 T MRI, with 3 readers showing higher confidence levels for reporting cartilage lesions on 3 T MRI.

Conclusions
In conclusion, new-generation 0.55 T DLR MRI provides good image quality, comparable to conventional 3 T MRI, and allows for reliable identification of internal derangement of the knee with high reader confidence.
NeuroNella: A Robust Unsupervised Algorithm for Identification of Neural Activity from Multielectrode Arrays
Authors: Germer C. , Farina D. , Baker S.N. , Del Vecchio A. 
Published: June 2024

ABSTRACTWe introduce NeuroNella, an automated algorithm developed for the identification of neuronal activity from multichannel electrode arrays. In evaluations conducted on recordings from implanted probes in the nervous system of rodents and primates, the algorithm demonstrated remarkable accuracy, showcasing an error rate of less than 1% compared to ground-truth patch clamp signals. Notably, the proposed algorithm handles large datasets efficiently without the necessity of a GPU system. The results highlighted the algorithm’s efficacy in detecting sources in a wide amplitude range and its adaptability in accommodating minor probe shifts. Moreover, the high robustness exhibited by the algorithm in decomposing recordings lasting up to 30 minutes underscores its potential for enabling longitudinal studies and prolonged recording sessions, thus opening new avenues for future brain/machine interface applications.