bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anatomical structures in the maxillary sinus related to lateral sinus elevation: a cone beam computed tomographic analysis
Authors: Kang So‐Jin , Shin Seung‐Il , Herr Yeek , Kwon Young‐Hyuk , Kim Gyu‐Tae , Chung Jong‐Hyuk 
Published: December 2011

AbstractObjectivesThe objective of this study is to evaluate the anatomical structures in the maxillary sinus with relation to lateral approach sinus elevation utilizing cone beam computed tomography (CT) scans taken prior to sinus elevation surgery.Materials and methodsA total of 150 CT images were acquired from 150 patients (90 men and 60 women; mean age, 49.4 years, range 23–86 years) who were being treated with implant‐supported restorations in the posterior edentulous maxilla. Of the 150 CT scans, 65 were of the right sinus and 85 of the left sinus. Measurements of the anatomical structures in the maxillary sinus were conducted on the CT images.ResultsIn the mean width of the lateral wall, there were statistically significant values among the measurement points (P < 0.05). The anterior area of the sinus lateral wall was thicker than the posterior lateral wall. There was a statistically significant difference between the vessel diameter and lateral wall width (P < 0.05). As sinus lateral wall width increased, so did the vessel diameter. The mean distance to the inferior border of the vessel from the sinus floor and from the alveolar crest was 8.25 and 17.03 mm, respectively. The intraosseous group among the vessel position was 64.3%, so the intraosseous vessel could be visualized in CT scans at 64.3%. In angle A, the group of less than 30° was 4.8%. Schneiderian membrane perforation by narrow angle had a low risk. The prevalence of the septa related to Schneiderian membrane perforation was 44%. The distance to the inferior border of the vessel from the alveolar crest being less than 15 mm was 31%. The vessel diameter greater than 1 mm was 37.8%.ConclusionsBased on present research about utilizing cone beam CT scans for sinus elevation, the alteration of the lateral approach sinus elevation technique is highly recommended if complications such as membrane perforation or bleeding are expected.
MBL2, MASP2, AMELX, and ENAM gene polymorphisms and dental caries in Polish children
Authors: Olszowski T , Adler G , Janiszewska‐Olszowska J , Safranow K , Kaczmarczyk M 
Published: December 2011

Oral Diseases (2012) 18, 389–395Objective:  The aim of the study was to examine whether the MBL2 C(‐290)G and G161A, MASP2 A359G, AMELX C287T and C522T, and ENAM C2452T polymorphisms are associated with dental caries.Subjects and methods:  Genomic DNA of 95 Polish children with ‘higher caries experience’ (HC) and 84 subjects with ‘lower caries experience’ (LC) belonging to two age‐groups (5 and 13 years old) was extracted from the buccal mucosa. SNPs were genotyped with PCR‐RFLP methods.Results:  Among 5‐year‐old children, we found significantly higher percentage of subjects carrying MBL2 (‐290)G allele in HC group compared with LC group (43.2%vs 17.6%, P = 0.023). MBL2 C(‐290)G–G161A C–G haplotype was overrepresented in LC group in 5‐year‐olds (P = 0.01), while the opposite association was observed in 13‐year‐olds, where C–G was overrepresented in HC group (P = 0.028). In 5‐year‐old children, the frequency of MBL2 G–G haplotype was higher in HC group compared with LC subjects (P = 0.045), while the opposite association (with borderline significance) was observed in 13‐year‐old children (P = 0.057). SNPs in MASP2, AMELX, and ENAM were not associated with dental caries.Conclusion:  MBL2 gene polymorphism is associated with caries experience in Polish children, but the direction of this association seems to be opposite in primary and permanent dentition.
Demographic and behavioural profiles of patients with common oral mucosal lesions by a homogeneity analysis
Authors: Matranga D , Di Fede O , Paderni C , Albanese A , Pizzo G , Magro R , Compilato D , Campisi G 
Published: December 2011

Oral Diseases(2012)18, 396–401Objective: The aim of this study is to assess the main oral mucosal lesions (OMLs) within a hospital base and to provide an anamnestic, diagnostic model based on homogeneity analysis of some variables.Methods: The demographic and behavioural data (i.e. gender, age, smoking status, alcohol consumption and therapeutic drug usage) of 1753 patients with at least one OML were considered. Multiple correspondence analysis (MCA) and multivariate tests of the simultaneous marginal homogeneity hypothesis (SMH) were used to analyse the evidence of any differences between the demographic and behavioural profiles relating to OMLs diagnoses. Statistical significance ofP < 0.05 was chosen.Results: With respect to the model used, patients affected by oral squamous cell carcinoma (n = 65; 3.5%) and oral leukoplakia (n = 73; 4.0%) differed significantly for demographic and behavioural characteristics analyzed, in particular with respect to gender (63.9%vs50.1% males) and alcohol consumption (29.1%vs12.1%). Patients affected by burning mouth syndrome (n = 134; 7.3%) and bisphosphonate‐related osteonecrosis of the jaw (n = 40; 2.2%) differed significantly for chronic use of drugs (45.7%vs71.6%). Finally, patients with halitosis (n = 60; 3.3%) and recurrent aphthous stomatitis (n = 103; 5.6%) showed similar profile, mainly in terms of men (47.6%), drinker (4.8%), drug user (34.9%), ≥60 years old (20.8%) and smoker (6.4%).Conclusion: Knowledge of some similarities in patients’ profile could help in positing the likely presence of OML when making diagnosis process by either general physicians or dentists, especially those without extensive experience in the field of oral medicine.
Effect of summer heat environment on body temperature, estrous cycles and blood antioxidant levels in Japanese Black cow
Authors: SAKATANI Miki , BALBOULA Ahmed Z. , YAMANAKA Kenichi , TAKAHASHI Masashi 
Published: December 2011

ABSTRACTThis study investigated the effect of summer heat environment on estrous cycles and blood antioxidant levels in Japanese Black cows. A total of 13 non‐lactating Japanese Black cows (summer: 9, winter: 4) were examined. Body temperature was measured rectally and intravaginally using a thermometer and data logger, respectively. Estrous behavior was monitored using a radiotelemetric pedometer that recorded walking activity. Rectal temperatures were higher during summer than winter (P < 0.001). There was an acute increase in vaginal temperature at the onset of estrus during winter but such an increase was not observed during summer. Walking activity during estrus decreased dramatically in the summer compared to the winter. Duration of estrous cycle was longer in summer (23.4 days, P < 0.05) than winter (21.5 days), and the subsequent rise in progesterone concentrations following estrus tended to be delayed in summer. The level of thiobarbituric acid reactive substances (TBARS) in peripheral blood cells was higher during summer (P < 0.05), while the levels of superoixde dismutase (SOD), glutathione peroxidase (GPx) and glutathione were lower (P < 0.05). These results indicate that high ambient temperature during summer increases both body temperature and oxidative stress, and also reduces signs of estrus in Japanese Black cows.
In vivo gene transfer into skeletal muscle of neonatal chicks by electroporation
Authors: IJIRI Daichi , SAEGUSA Akito , MATSUBARA Tomoko , KANAI Yukio , HIRABAYASHI Miho 
Published: December 2011

ABSTRACTChicks (Gallus gallus domesticus) show considerable growth of skeletal muscle during the neonatal period. The in vivo gene transfer method is useful for studying gene function and can be employed to elucidate the molecular mechanisms of skeletal muscle growth in chicks. We evaluated the following conditions for gene transfer to the skeletal muscle of neonatal chicks by electroporation: (i) voltage; (ii) age of the chick; (iii) plasmid DNA injected amount; and (iv) duration of gene expression. The results obtained from this study indicate that the most efficient gene transfer condition was as follows: 75 µg of plasmid DNA encoding β‐galactosidase was injected into the gastrocnemius muscle of chicks at 4 days of age electroporated at 50 V/cm. In addition, peak transferred gene expression was observed from 3 days to 5 days after electroporation. Our results provide optimal electroporation conditions for elucidating the gene function related to skeletal muscle growth and development in neonatal chicks.
Barriers and Enablers to Implementation of a New Zealand‐Wide Guideline for Assessment and Management of Cardiovascular Risk in Primary Health Care: A Template Analysis
Authors: McKillop Ann , Crisp Jackie , Walsh Kenneth 
Published: December 2011

ABSTRACTAim: The aim of this study was to identify the enablers and barriers to guideline implementation in a primary healthcare setting by employing the Promoting Action on Research Implementation in Health Services (PARIHS) framework as a template for data analysis and interpretation.Background: The use of clinical practice guidelines is pivotal to improving health outcomes. However, the implementation of guidelines into practice is complex, unpredictable, and, in spite of much investigation, remains resistant to explanation of what works and why. Optimising the enablers and minimising the barriers to implementation of a guideline for reducing cardiovascular disease risk has the potential to significantly reduce the burden of disease. The PARIHS framework has been successfully applied in a number of clinical contexts and has been found useful in illuminating the barriers and enablers to evidence implementation.Approach: This qualitative study involved focus groups with 20 primary healthcare nurses, 4 general practitioners, 5 managers, and individual interviews with 3 funder/planners who discussed their contribution to the use of a guideline for the assessment and management of cardiovascular risk. Template analysis based on the PARIHS framework was applied to semi‐structured narrative data to provide an in‐depth analysis of the barriers and enablers to implementation of the guideline.Conclusions: The lack of facilitation of the guideline into practice was a major barrier to implementation. Implementation plans that address the concerns and complexities of everyday practice are an essential aspect of guideline development. The PARIHS framework was found to be comprehensive and accommodating of the complexity of everyday practice associated with guideline implementation in primary health care. The pertinence of the framework confirms its usefulness as a tool to guide implementation.
Neoplastic infiltration of the sphenoid wing: A rare manifestation of metastatic colorectal cancer
Authors: PINATO David James , KRELL Jonathan , WASAN Harpreet , SHARMA Rohini 
Published: December 2011

AbstractAtypical patterns of metastatic spread from colorectal primary tumors are often misdiagnosed, with potential implications for the clinical outcome. Metastatic diffusion to the splanchnocranium is extremely rare in colorectal cancer. A histological proof of diagnosis is rarely obtained and therapeutic management is a challenge. We describe the case of a 46‐year‐old patient who presented with a radiologically proven sphenoid wing metastasis. The patient presented with left‐sided exophthalmos while receiving systemic chemotherapy for relapsed high‐risk colorectal cancer. A left sphenoid wing metastasis was proven by a head computed tomography scan. A metastatic spread to the sino‐nasal tract is regarded as a poor prognosis determinant in colorectal cancer and presents a unique set of diagnostic and therapeutic challenges. The compression of noble structures such as the optic nerve holds serious implications in terms of quality of life but there is insufficient evidence clarifying whether radiotherapy or surgery represent the best option for these patients, leaving the therapeutic plan to be decided case by case.
The Association between Major Depression, Health Behaviors, and Quality of Life in Adults with Stroke
Authors: Ellis Charles , Grubaugh Anouk L. , Egede Leonard E. 
Published: December 2011

Aim The study aims to examine the association between major depression, healthcare behaviors, and quality of life indices among adults with stroke. Methods Data from 5869 participants with stroke in the 2006 Behavioral Risk Factor Surveillance Survey were examined. Multiple logistic regression was used to assess the independent association between depression status, self-care and preventive health behaviors, and quality of life indices, after accounting for relevant covariates. Results In multivariate models, individuals with major depression were less likely to engage in physical activity (odds ratio 0.41; 95% confidence interval 0.29, 0.56) than those without major depression. Women with major depression were also less likely to have received a mammogram in the past two-years (odds ratio 0.61; 95% confidence interval 0.40, 0.96 for women ≥ age 40 and odds ratio 0.58; 95% confidence interval 0.36, 0.72 for women ≥ age 50) and a pap smear in the past three-years (odds ratio 0.40; 95% CI 0.22, 0.72). In comparisons of quality of life, individuals with major depression were less likely to perceive their health as excellent/very good/good (odds ratio 0.36; 95% confidence interval 0.25, 0.53), to report being satisfied with life (odds ratio 0.13; 95% confidence interval 0.08, 0.20), and to report receiving needed social support (odds ratio 0.42; 95% confidence interval 0.28, 0.63). Individuals who were depressed were also more likely to report one or more poor physical and poor mental health days in the past 30 days (odds ratio 4.56; 95% confidence interval 3.08, 6.76 and odds ratio 10.97; 95% confidence interval 7.75, 15.52, respectively). Conclusions In adults with stroke, major depression is associated with decreased engagement in stroke-specific and gender-specific self-care and preventive health behaviors, as well as a broad range of quality of life indices.
Does Acute Behavioral Testing Reflect Successful Ischemia in Rats with Transient Middle Cerebral Artery Occlusion?
Authors: Chauveau Fabien , Cho Tae-Hee , Riou Adrien , Langlois Jean-Baptiste , Berthezène Yves , Nighoghossian Norbert , Wiart Marlène 
Published: December 2011

Background Models of intraluminal middle cerebral artery occlusion present an intrinsic variability in infarct size. Behavioral evaluation is frequently performed during arterial occlusion to confirm success of surgery. Aims and/or hypothesis We compared the value of behavioral testing and multimodal magnetic resonance imaging performed during arterial occlusion for identifying successfully operated animals. Methods Rats were tested with behavioral assessment (using three scoring scales and the adhesive removal test) and multimodal magnetic resonance imaging (including magnetic resonance angiography, diffusion-weighted and perfusion-weighted imaging), both performed during the two-hours of middle cerebral artery occlusion using the intraluminal suture model. Behavioral assessment was repeated 24 h after reperfusion, followed by sacrifice. Results Acute apparent diffusion coefficient lesion volume was correlated with both 2,3,5-triphenyl tetrazolium chloride infarct size ( r = 0.75, P = 0.02) and behavioral status ( r = 0.66, P = 0.05) on day one. Conversely, no correlation was found between acute behavioral examination and day one outcomes (2,3,5-triphenyl tetrazolium chloride infarct volume, r = 0.40, P = 0.28; behavioral examination, r = 0.39, P = 0.30). Day zero apparent diffusion coefficient volumes ( P = 0.04), but not behavioral assessment ( P = 0.60), discriminated animals with day one corticostriatal infarcts from these with subcortical infarcts. Conclusions Acute behavioral testing performed during arterial occlusion fails to identify successfully operated animals. Acute diffusion magnetic resonance imaging may be more appropriate to assess and reduce infarct size variability in this model.
Factors Associated with Severity on Admission and In-Hospital Mortality after Primary Intracerebral Hemorrhage in China
Authors: Fu Xian , Wong Ka Sing , Wei Jade W. , Chen Xiangyan , Lin Yueqing , Zeng JinSheng , Huang Ruxun , Gao Qingchun 
Published: December 2011

Background and purpose Of the stroke types, intracerebral hemorrhage is the most debilitating and fatal. The aim of the current study was to determine factors that influence the severity and in-hospital mortality after primary intracerebral hemorrhage. Methods Data were collected retrospectively on 1268 patients with primary intracerebral hemorrhage admitted to stroke units at participating hospitals in Guangzhou between January 2005 and August 2008. Logistic regression analysis was used to determine factors associated with severity on admission and in-hospital mortality. Results Of the 1268 patients, 20·4% were reported to have a severe stroke on admission, and the in-hospital mortality rate was 12·5%. Severity on admission was strongly associated with Glasgow Coma Scale score on admission (odds ratio = 0·89, 95% confidence interval 0·85–0·94) and hematoma location. Notably, basal ganglia hemorrhages were associated with increased severity (odds ratio = 1·40, 95% confidence interval 1·03–1·90), and cerebellar hemorrhages were associated with reduced severity (odds ratio = 0·29, 95% confidence interval 0·10–0·84). In-hospital mortality was not only correlated with Glasgow Coma Scale score on admission (odds ratio = 0·79, 95% confidence interval 0·74–0·84) and basal ganglia location (odds ratio = 0·47, 95% confidence interval 0·26–0·83), but also with dysnatremia (odds ratio =1·91, 95% confidence interval 1·08–3·40) and comorbidities such as upper gastrointestinal hemorrhage (odds ratio = 2·28, 95% confidence interval 1·33–3·91), pneumonia (odds ratio = 3·50, 95% confidence interval 2·17–5·63), urinary incontinence (odds ratio = 2·22, 95% confidence interval 1·40–3·51), and renal dysfunction (odds ratio = 2·28, 95% confidence interval 1·42–3·65). Conclusion Glasgow Coma Scale score and hematoma locations were independently associated with severity on admission and in-hospital mortality after primary intracerebral hemorrhage. The study also highlights the deleterious effect of comorbidities on in-hospital mortality following primary intracerebral hemorrhage in China.
Evidence on the Effects of Money Growth on Inflation with Regime Switching
Authors: Liu Jinquan , Pang Chunyang 
Published: December 2011

AbstractSince the latter half of 2010, a new round of inflation has gradually been manifesting in China. The debate regarding whether excess money supply is responsible for this inflation has attracted scholars to investigate the effects of money growth on inflation. In this paper, we use correlation analysis to confirm the comovement between growth of monetary aggregates and inflation. We explore the asymmetric effects of monetary policy on inflation using the Markov regime‐switching model. The empirical results show that monetary policy can be more effective in curbing inflation in a high inflation state than in boosting the price level in a low inflation state. However, simply tightening the money supply might not be sufficient to suppress the price level. To this end, the Chinese Government should adopt other policies, such as supply stabilization policies, to help suppress the price level. Our study can help policy‐makers to determine the actual economic state and provides some policy implications for the current inflation.
Autophagy Dysregulation in Amyotrophic Lateral Sclerosis
Authors: Chen Sheng , Zhang Xiaojie , Song Lin , Le Weidong 
Published: December 2011

AbstractAutophagy is an intracellular lysosomal degradation process, which plays an important role in cell growth and development, and keeping cellular homeostasis in all eukaryotes. Autophagy has multiple physiological functions, including protein degradation, organelle turnover and response to stress. Emerging evidences support the notion that dysregulation of autophagy might be critical for pathogenesis of amyotrophic lateral sclerosis (ALS). The autophagy dysregulation in motor neurons of ALS may occur in different steps of the autophagic process. Recent studies have shown that two ALS associated proteins, TDP‐43 and superoxide dismutase 1 (SOD1), are involved in the abnormal autophagy regulation. Furthermore, it is reported that several genetic mutations in ALS disturb the autophagic process in the motor neurons. This review will provide new evidence of autophagy dysregulation as a critical pathogenic process leading to ALS, and will discuss the prospect of future therapeutic targets using autophagic regulation to treat this disease.
Postoperative microhyphema as a positive prognostic indicator in canaloplasty
Authors: Grieshaber Matthias C. , Schoetzau Andreas , Flammer Josef , Orgül Selim 
Published: December 2011

Abstract.Purpose:  To assess risk factors for failure in canaloplasty.Methods:  Nonrandomized prospective study involving 51 eyes of 51 patients with medically uncontrolled primary open‐angle glaucoma undergoing canaloplasty. Visual acuity, intraocular pressure (IOP) and slit‐lamp examinations were performed before and after surgery at 1 and 7 days, and at 1 month and every 3 months thereafter. Factors like age, gender, preoperative IOP and microhyphema on day 1 were evaluated.Results:  The mean follow‐up was 20.6 (SD 8.3) months. The mean preoperative IOP was 26.8 (SD 5.2) mmHg; the mean postoperative IOP was 8.4 (4.2) mmHg at day 1 and 12.7 (1.7) mmHg at month 24. Microhyphema was found in 40 patients (85.1%) on day 1 after surgery. The height of microhyphema was 1.8 mm ± 0.4 (SD) (range 1–2.5), and the time of resorption was 6.6 days ± 2.8 (SD) (range 3–14) on average. No recurrence of hyphema has been observed. IOP < 16 mmHg without medications depended significantly on the presence of microhyphema (hazard ratios, HR 0.03, 95% CI 0.01–0.25, p < 0.001), but not on age (HR 1.00, 95% CI 0.91–1.09, p = 0.32), preoperative IOP (HR 0.98, 95% CI 0.85–1.12, p = 0.80), cup‐to‐disc ratio (HR 0.15, 95% CI 0.00–20.01, p = 0.45) and gender (HR 0.24, 95% CI 0.05–1.12, p = 0.07). Factors like preoperative IOP, age, gender, cup‐to‐disc ratio were not associated with microhyphema. There were no significant differences between patients with versus without microhyphema in regard to age, preoperative IOP, morphological and functional glaucomatous damage, number of medications and postoperative day 1 IOP. However, patients with microhyphema had significantly fewer Nd:YAG goniopunctures after surgery than patients without microhyphema (p < 0.001).Conclusion:  Microhyphema the first postoperative day seems to be a significant positive prognostic indicator in uneventful canaloplasty in regard to IOP reduction, possibly representing a restored and patent physiologic aqueous outflow system.