bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mucoepidermoid carcinoma of the parotid gland: Factors affecting outcome
Authors: Ghosh‐Laskar Sarbani , Murthy Vedang , Wadasadawala Tabassum , Agarwal Jaiprakash , Budrukkar Ashwini , Patil Nikhilesh , Kane Shubhada , Chaukar Devendra , Pai Prathamesh , Chaturvedi Pankaj , D'Cruz Anil 
Published: July 2010

AbstractBackgroundThe purpose of this study was to identify the prognostic factors affecting the outcome in patients with mucoepidermoid carcinoma (MEC) of the parotid gland.MethodsA total of 113 patients with MEC who were treated between 1993 and 2002 were analyzed.ResultsAt median follow‐up of 49 months (range, 1–143 months), disease‐free survival (DFS) at 5 and 10 years was 84.6 and 84.6%, 80.7% and 67.3%, and 52.5% and 35.0% for low‐grade, intermediate‐grade, and high‐grade tumors, respectively. Five‐year and 10‐year overall survival was 96.8% for low‐grade tumors; 94.1% and 82.4%, respectively, for intermediate‐grade tumors; and 73.3% for high‐grade tumors. High‐grade tumors and lymph node cancer‐positive neck tumors strongly predicted poor locoregional control and DFS, while close or positive cut margins showed a trend toward poorer outcomes.ConclusionHistologic grade is the most important factor affecting outcome in parotid MEC. Adjuvant radiotherapy is recommended for high‐grade tumors and should be tailored according to the expected risk of recurrence for low‐grade and intermediate‐grade tumors. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Analyzing governance reforms in irrigation: Central, South and West Asian experience
Authors: Ul Hassan Muhammad Mehmood 
Published: July 2010

AbstractThe concepts of irrigation governance and management are often confused while reforming irrigation institutions. This paper distinguishes between irrigation governance and management and articulates the governance concept and its ingredients through a literature review. The governance performance of irrigation reforms from selected cases in Asia is analyzed using a conceptual model. The paper identifies five key concepts in analyzing governance reform as institutions, intentions, instruments, implementation and impact. The analysis reveals that poor governance results from poor design of representation and accountability in the reform. The interplay between institutions, their intentions, instruments and implementation arrangements used by reformers in the selected cases have tended to create information asymmetries amongst the users, which have led to poor awareness and participation by potential members for effective governance. When reforming irrigation governance attention needs to be paid to institutions, reform intentions, instruments, and implementation arrangements simultaneously. Design weaknesses of any one of these four components of governance can lead to suboptimal impacts. The studied management transfer programs remained unable to improve irrigation governance owing to weakness in one or more of these governance ingredients. Copyright © 2010 John Wiley & Sons, Ltd.
OCT‐guided laser hyperthermia with passively tumor‐targeted gold nanoparticles
Authors: Sirotkina Marina A. , Elagin Vadim V. , Shirmanova Marina V. , Bugrova Marina L. , Snopova Ludmila B. , Kamensky Vladislav A. , Nadtochenko Victor A. , Denisov Nikolay N. , Zagaynova Elena V. 
Published: July 2010

AbstractThe goal of this study is the development of a method of local laser hyperthermia with gold nanoparticles under noninvasive optical monitoring of nanoparticle accumulation in tumor tissue in vivo. Bifunctional plasmon resonant nanoparticles that are optimal for OCT diagnostics and laser heating at the wavelength of 810 nm were used in the study. The OCT examination showed that the accumulation of gold nanoparticles in the tumor invading into skin was maximal 4–5 h after intravenous injection. It was demonstrated that nanoparticle accumulation in tumor allowed more local heating and enhanced thermal sensitivity of tumor tissue. Laser hyperthermia that heated tumor up to 44–45 °C at maximum nanoparticle accumulation induced apoptotic death of tumor cells and inhibited tumor growth by 104% on the 5th day after treatment. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Efficacy of two breath condensers
Authors: Davidsson A. , Schmekel B. 
Published: July 2010

AbstractBackground: Examination of Exhaled Breath Condensate has been suggested to give information about inflammatory airway diseases. Objectives: The aim was to compare efficacy and variability in gain of two commercially available exhaled breath condensers, ECoScreen® and RTube™ in an in vitro set up. Methods: Test fluids containing myeloperoxidase (MPO) or human neutrophil lipocalin (HNL) in addition to saline and bovine serum albumin were nebulized and aerosols were transferred by a servo ventilator to either of the two condensers. Analyses of MPO, HNL, or chlorine were done by means of ELISA, RIA, or a modified adsorbed organic halogen technique (AOX), respectively. Results: Recoveries of HNL were higher when using ECoScreen than RTube (P<0.05). In contrast, there were no significant differences between the two condensers in recoveries of MPO or chlorine. The spread of data was wide regarding all tested compounds. Conclusion: Variability in gain was large and ECoScreen was more efficacious then RTube in condensing the tested solutes of HNL, but not those of MPO or chlorine J. Clin. Lab. Anal. 24:219–223, 2010. © 2010 Wiley‐Liss, Inc.
Determination of cut‐off titers and agreement between immunofluorescence and immunoblotting methods for detecting antinuclear antibodies in children
Authors: Aksu G. , Gulez N. , Azarsız E. , Karaca N. , Kutukçuler N. 
Published: July 2010

AbstractDetection of antinuclear antibodies (ANA) is a diagnostic adjunct in patients with suspected autoimmune connective tissue diseases, and various detection methods are in use. The aim of this study was to analyze the agreement between the ANA immunoflourescence (IF) and immunoblotting (IB) methods and determine cut‐off for children subjects in a laboratory setting. We evaluated 729 serum samples that were analyzed by both ANA IF and IB. The results were evaluated by χ2 test and, for agreement, κ index was used. Frequencies determined for both 1:40–1:100 cut‐off titers of ANA IF in relation to IB testing supported the idea that 1:100 starting dilution should be recommended in children subjects for ANA IF method and antigen specific immunoblot testing was needed, especially for some of the ANA IF negative samples. Agreement between the two methods, especially with homogenous, granular, and nucleolar ANA IF patterns, was statistically significant. J. Clin. Lab. Anal. 24:230–236, 2010. © 2010 Wiley‐Liss, Inc.
Plasma levels of matrix metalloproteinase‐8 in patients with carotid atherosclerosis
Authors: Djurić Tamara , Živković Maja , Stanković Aleksandra , Kolaković Ana , Jekić Djole , Selaković Vesna , Alavantić Dragan 
Published: July 2010

AbstractMatrix metalloproteinases (MMPs) are involved in the remodeling of the extracellular matrix (ECM) in the arterial wall during atherogenesis. Collagens are the most abundant proteins in the ECM. MMP‐8 is expressed by cells associated with the development of the atherosclerotic plaque. It cleaves collagen type I three times more potently than two other interstitial collagenases MMP‐1 and MMP‐13. The aim of this study was to investigate whether plasma MMP‐8 values are associated with occurrence of carotid plaque (CP) and possible correlations with clinical and biochemical parameters in carotid atherosclerosis (CA) patients. Total plasma MMP‐8 levels were quantified by ELISA in 63 patients with ultrasonographic evidence of CP presence and 12 controls. Plasma MMP‐8 values were significantly higher in patients with CA compared with controls (median 23.36 ng/ml vs. 13.02 ng/ml, P<0.001) but they did not differ significantly according to gender, smoking and hypertensive status, associated diseases, and use of statins. Statistically significant positive correlations were observed between MMP‐8 plasma values and C reactive protein (r=0.41, P=0.001), urea (r=0.50, P<0.001), aspartate transaminase (r=0.48, P=0.001), and creatinine levels (r=0.38, P=0.006). These results suggest association of MMP‐8 plasma levels with occurrence of CP and correlation with certain biochemical markers. J. Clin. Lab. Anal. 24:246–251, 2010. © 2010 Wiley‐Liss, Inc.
Flow cytometric reticulocyte counting: a comparison between two methods
Authors: Maconi M. , Danise P. , Cavalca L. , Formisano D. 
Published: July 2010

AbstractThe peripheral reticulocyte count is commonly used as an indicator of the erythropoietic activity of the bone marrow. Manual counting provides results with a high degree of inaccuracy and imprecision. Automation of counting is therefore needed. The increase in the number of methods available requires however that the results from the various methods agree with one another. The aim of our study was to evaluate the analytic performance of two automated hematology analyzers by a parallel study. We compared the analyzers between them and with manual counting. We enrolled in our study a total of 100 healthy subjects and an additional 80 patients affected by various hematological diseases. Difference between methods is statistically significant: the reference intervals of ADVIA2120 are higher than the Sysmex XE‐2100. The correlation between methods and correlation with the microscopic method are excellent and statistically significant. In conclusion, we can affirm that total automation of reticulocyte counts represents a definite improvement over microscopic counts. This study confirms the diversity of the reference intervals still exists in the new automated hematology analyzers. J. Clin. Lab. Anal. 24:252–255, 2010. © 2010 Wiley‐Liss, Inc.
Diagnostic usefulness of serum interleukin 6 (IL‐6) and C‐reactive protein (CRP) in the differentiation between pancreatic cancer and chronic pancreatitis
Authors: Mroczko Barbara , Groblewska Magdalena , Gryko Mariusz , Kędra Bogusław , Szmitkowski Maciej 
Published: July 2010

AbstractPrevious studies have shown elevated serum levels of interleukin 6 (IL‐6) and C‐reactive protein (CRP) in patients with pancreatic cancer (PC). The aim of this study was to assess the diagnostic usefulness of pretreatment serum levels of IL‐6 and CRP to differentiate between PC and chronic pancreatitis (CP) patients. Serum levels of CRP, IL‐6, carcinoembryonic antigen (CEA), and carbohydrate antigen 19‐9 (CA 19‐9) were determined in 78 patients with PC before surgery, in 45 patients with CP, and in 70 healthy controls. Serum levels of all the proteins tested were significantly higher in cancer patients when compared with CP and healthy subjects, and increased in more advanced tumor stages. Concentrations of IL‐6 were significantly higher in nonresectable tumors and in patients who died during the 2‐year observation period. Area under receiver operating characteristic curve for IL‐6 was higher than for other substances tested in the differentiation between PC and CP. Cox's univariate analysis revealed serum IL‐6 as a significant prognostic factor of patients' survival. Our findings suggest higher diagnostic usefulness of serum IL‐6 than CRP, CEA, and CA 19‐9 in the diagnosis and prognosis of patients with PC and in the differentiation with CP. J. Clin. Lab. Anal. 24:256–261, 2010. © 2010 Wiley‐Liss, Inc.
Human lymphocyte antigen B‐associated transcript 2, 3, and 5 polymorphisms and haplotypes are associated with susceptibility of Kawasaki disease and coronary artery aneurysm
Authors: Hsieh Yao‐Yuan , Lin Ying‐Ju , Chang Chi‐Chen , Chen Da‐Yuan , Hsu Chin‐Mu , Lo Ming‐Min , Hsu Kung‐Hao , Tsai Fuu‐Jen 
Published: July 2010

AbstractCapsule: HLA‐B associated transcript (BAT) 2, 3, and 5 polymorphisms and haplotypes are associated with Kawasaki disease (KD) and coronary artery aneurysm (CAA) formations. Objective: KD, an acute vasculitis with unknown etiology, involves a complex interaction of immuno‐inflammatory process, cytokines activation, and genetic factors. We aimed to investigate if genetic variants of human lymphocyte antigen (HLA)‐BAT2, 3, and 5 (BAT2, 3, and 5) could be used as markers of susceptibility in KD and CAA. Methods: Individuals were divided into three groups: (1) normal controls; (2) KD with CAA; and (3) KD without CAA. Polymorphisms for BAT2 (−8671, 16483), BAT3 (8854, 2–24), and BAT5 (22655, 9569) were genotyped by PCR system with TaqMan allelic discrimination assay. Genotype/allelic frequencies and haplotypes (BAT2−8671‐BAT216483‐BAT38854‐BAT32–24‐BAT522655‐BAT59569) in each group were compared. Results: Genotype distribution and allele frequency of BAT2 −8671, BAT3 8854, and BAT5 22655, 9569 polymorphisms in each group were significantly different. BAT2 −8671*G, BAT3 8854*C, BAT5 22655*C, and 9569*A‐related genotypes and alleles are correlated with the developments of KD and CAA. BAT haplotypes of ATTGTG and ATCATG are associated with higher susceptibilities of KD with CAA susceptibility. Conclusion: BAT2 −8671, BAT3 8854, and BAT5 22655, 9569 polymorphisms as well as BAT haplotypes (ATTGTG and ATCATG) might be associated with higher KD susceptibility and CAA formation. HLA‐B region polymorphisms might contribute to the pathogenesis of KD and CAA. J. Clin. Lab. Anal. 24:262–268, 2010. © 2010 Wiley‐Liss, Inc.
Measuring sense of community in the military: cross‐cultural evidence for the validity of the brief sense of community scale and its underlying theory
Authors: Wombacher Jörg , Tagg Stephen K. , Bürgi Thomas , MacBryde Jillian 
Published: July 2010

AbstractIn this article, the authors present a German Sense of Community (SOC) Scale for use in military settings. The scale is based on the translation and field‐testing of an existing U.S.‐based measure of neighborhood SOC (Peterson, Speer, & McMillan, 2008). The methodological intricacies underlying cross‐cultural scale development are highlighted, as are the strategies used to overcome them. Administered in a navy context (n=270), the newly developed German measure improves the psychometric credentials of the existing scale by confirming the principal theory of SOC and its applicability across borders and contexts. Future research is encouraged to build on the strength and flexibility of the existing U.S. instrument for further cross‐cultural scale development, thus enabling SOC theory to attain its full international potential. © 2010 Wiley Periodicals, Inc.
Associations among socioeconomic status, perceived neighborhood control, perceived individual control, and self‐reported health
Authors: Moore Spencer , Daniel Mark , Bockenholt Ulf , Gauvin Lise , Richard Lucie , Stewart Steven , Dubé Laurette 
Published: July 2010

AbstractRecent research has suggested that perceived control and a person's perceptions of their neighborhood environment may mediate the association between socioeconomic status (SES) and health. This cross‐sectional study assessed whether perceptions of informal social control mediated the association between SES and self‐reported health, and if these two constructs represented distinct mechanisms linking SES with self‐reported health. The sample consisted of 869 adults residing in 300 census tracts in Montreal, Canada. Multilevel methods were used to assess the associations among self‐reported health, SES, perceived control, and perceived informal social control adjusting for sociodemographic variables. Perceived control (mediation estimate=−0.16, p<.001) and perceived informal social control (mediation estimate=−0.05, p<.05) partially mediated the association between SES and self‐reported health. Perceived control did not mediate the association of perceived informal social control with self‐reported health. Perceived informal social control may act alongside but distinct from perceived control as a mechanism linking SES to self‐reported health. © 2010 Wiley Periodicals, Inc.
Help‐seeking among male victims of partner abuse: men's hard times
Authors: Tsui Venus , Cheung Monit , Leung Patrick 
Published: July 2010

AbstractSixty‐eight agency representatives in the United States completed a survey to identify issues of male victims in partner abuse: half referenced responses from male clients and the other half responses from male victims who were their family members, friends, colleagues, or themselves. Almost 25% revealed that male victims did not utilize social services. For those men who used services, individual counseling and legal advice were most popular; group counseling and sharing through the Internet were least used. Qualitative data found five themes that triggered men's hard times: service target perception, shame and embarrassment, denial, stigmatization, and fear. The study resulted in three recommendations: (a) increase public awareness and education; (b) provide gender‐inclusive practice and services, and (c) strengthen training for service providers working with domestic violence male victims. © 2010 Wiley Periodicals, Inc.
Biocatalytic ester synthesis in ionic liquid media
Authors: Hernández‐Fernández Francisco J. , de los Ríos Antonia P. , Lozano‐Blanco Luis J. , Godínez Carlos 
Published: July 2010

AbstractIonic liquids have shown potential as green reaction media compared with organic solvents, mainly due to their lack of vapour pressure. In non‐aqueous enzymology, ionic liquids are opening up new fields. The advantages of using ionic liquids over the use of organic solvents as reaction medium for biocatalysis include enhancement of enzyme activity, stability and selectivity.In this work, the enzymatic synthesis of esters in ionic liquids has been extensively reviewed. Numerous examples of the application of ionic liquids as reaction medium for the enzymatic production of esters have been included. The effect of the nature of the ionic liquid on activity, selectivity and stability of enzymes which catalyze esters synthesis has been carefully analysed. Innovative reaction methodologies for the biosynthesis of esters, including ionic liquid/supercritical carbon dioxide biphasic systems and the integrated reaction/separation processes using supported liquid membranes based on ionic liquids have been revised. Copyright © 2010 Society of Chemical Industry
Bio‐electrochemical denitrification by a novel proton‐exchange membrane electrodialysis system—a batch mode study
Authors: Wan Dongjin , Liu Huijuan , Qu Jiuhui , Lei Pengju 
Published: July 2010

AbstractBACKGROUND: Contamination of nitrate in ground and surface water has become an ever‐increasing and serious environmental problem. Biological methods hold the promise of converting nitrate into harmless nitrogen. A novel denitrification system which combines proton‐exchange membrane electrodialysis with simultaneous bio‐electrochemical autotrophic denitrification has been developed. The proton‐exchange membrane was used to transfer current and to exclude oxygen or other oxidative chemicals generated in the anode reaction. The H2 generated by the cathode was utilized by autotrophic denitrifying microorganisms in the cathode cell to reduce nitrate. In this study, the transport of H+, a denitrification kinetics model and factors influencing the denitrification rate were explored in batch mode.RESULTS: The addition of 0.03 mol L−1 H2SO4 into the anode cell enhanced proton transport and maintained the pH of the cathode cell in an appropriate range for biological denitrification. The denitrification rate was affected by applied current and biomass. Under adequate current conditions, the kinetics of the denitrification process followed a zero‐order kinetics model; the average denitrification rate for unit biomass was calculated to be 9.36 mg NO3−‐N VSS g−1 h−1.CONCLUSIONS: Results indicate that the system is suitable for denitrification. Owing to its simple structure and operation, it has the potential for use as a system to reduce nitrate in water. Copyright © 2010 Society of Chemical Industry
Model simulations for in situ aerobic cometabolism of trichloroethylene
Authors: Su Chien Y. , Kuo M.C. Tom , Liang Kang F. , Lin Chun Y. 
Published: July 2010

AbstractBACKGROUND: While overall removal of trichloroethylene (TCE) can be estimated from in situ pilot studies of aerobic cometabolism, no quantitative information on the relative importance of the biodegradation and sorption processes is currently available. This paper presents a quantitative method to evaluate the dynamics and the individual removal efficiencies of cometabolic biodegradation and sorption processes using model simulations for in situ aerobic cometabolism.RESULTS: The first‐order rate constant of TCE cometabolism by aerobic toluene‐utilizing bacteria was around 0.2 to 0.3 L mg−1 day−1. The TCE partition coefficient of sorption was determined at 16.4 L kg−1. The sorption process diminished as the sorption capacity of the aquifer solids became saturated. The sustainable TCE removal efficiency due to cometabolic biodegradation for the in situ pilot was determined at 25.8%, 51.8%, and 75.2% for residence times of 0.14 day, 0.57 day, and 1.16 day, respectively, after establishing an indigenous toluene‐degrading consortium.CONCLUSION: The agreement between model simulations and pilot results demonstrates the validity of a model that incorporates fundamental microbial and transport processes of advection, dispersion, and sorption onto the aquifer solids. The mathematical model aids the understanding of both the dynamics and the individual removal efficiencies of sorption and biodegradation processes of in situ bioremediation. Copyright © 2010 Society of Chemical Industry
Synthesis of some novel 3‐alkyl/aryl‐6‐((1H‐benzo[d][1,2,3]triazol‐1‐yl)methyl)‐[1,2,4]triazolo[3,4‐b][1,3,4]thiadiazoles
Authors: Chen Xiqing , Liu Chenjiang , Wang Jide , Li Yanping 
Published: July 2010

Abstractmagnified imageA series of 3‐alkyl/aryl substituted‐6‐((1H‐benzo[d][1,2,3]triazol‐1‐yl)methyl)‐[1,2,4]triazolo[3,4‐b][1, 3,4]thiadizoles4a,4b,4c,4d,4e,4f,4g,4h,4i,4j,4k,4l,4mare prepared by the condensation of 3‐alkyl/aryl substituted‐4‐amino‐5‐mercapto‐1,2,4‐triazoles2a,2b,2c,2d,2e,2f,2g,2h,2i,2j,2k,2l,2mwith benzotriazole‐1‐yl acetic acid3through a single step reaction. The structures of all newly synthesized compounds are established on the basis of their IR,1H NMR, and elemental analyses data. Two selected compounds4land4mare investigated for their analgesic and anti‐inflammatory activities; they showed weak anti‐inflammatory activity and no analgesic activity. J. Heterocyclic Chem., (2010).
Synthesis and crystal structure of 3,5‐diacetyl‐4‐methylpyrazole
Authors: Outirite Moha , Bentiss Fouad , Buisine Eric , Capet Frédéric , Lagrenée Michel 
Published: July 2010

Abstract
magnified image The 3,5‐diacetyl‐4‐methylpyrazole diketone has been synthesized and its crystal structure has been determined. This diketone reacts with hydroxylamine hydrochloride to give the dioxime derivative. This reaction, conducted in presence of copper II ions, leads to the formation of L2M2 copper II complexes. J. Heterocyclic Chem., (2010).
Facile synthesis of 2,4‐diamino‐6‐alkyl‐ or 6‐aryl‐pyrimidine derivatives
Authors: Wang Xihong , Sathunuru Ramadas , Melendez Victor , Kozar Michael P. , Lin Ai J. 
Published: July 2010

Abstract
magnified image Facile methods were developed to prepare a series of 6‐phenyl and 6‐alkyl‐2,4‐diaminopyrimidine derivatives. The pyrimidine ring of the final products was constructed by treatment of a 1,3‐dicarbonyl derivative with an amidine or guanidine. The 6‐phenyl‐pyrimidine derivatives were also prepared by Suzuki coupling reaction, using 2‐methylthio‐4,6‐dichloropyrimidine as the starting material. J. Heterocyclic Chem., (2010).