bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isoflavones from Phytoestrogens and Gastric Cancer Risk: A Nested Case-Control Study within the Korean Multicenter Cancer Cohort
Authors: Ko Kwang-Pil , Park Sue K. , Park Boyoung , Yang Jae Jeong , Cho Lisa Y. , Kang Chungwon , Kim Cheong Sik , Gwack Jin , Shin Aesun , Kim Yeonju , Kim Jeongseon , Yang Han-Kwang , Kang Daehee , Chang Soung-Hoon , Shin Hai-Rim , Yoo Keun-Young 
Published: May 2010

AbstractBackground: The role of soybean products in gastric cancer risk is not clear in epidemiologic studies due to measurement error from dietary intake questionnaires and due to different degrees of bias according to study design. To examine the association between soybean products and gastric cancer risk, we measured phytoestrogen biological markers in a nested case-control study.Methods: The study population was composed of 131 cases and 393 matched controls within the Korean Multicenter Cancer Cohort. The concentrations of the four biomarkers in the plasma samples were measured using time-resolved fluoroimmunoassay. Conditional and unconditional logistic regression models were used to compute the odds ratio (OR) and 95% confidence intervals (CI).Results: Median plasma concentrations of genistein (229 nmol/L for controls, 181.8 nmol/L for cases; P = 0.07) and daidzein (131.2 nmol/L for controls, 80.5 nmol/L for cases; P = 0.04) in cases were lower than in controls, whereas equol concentrations were similar. Compared with the reference group, gastric cancer risk decreased in the highest groups for genistein (OR, 0.54; 95% CI, 0.31-0.93) and daidzein (OR, 0.21; 95% CI, 0.08-0.58). Higher equol concentrations were associated with a decreased risk for gastric cancer (OR, 0.50; 95% CI, 0.27-0.90). The combination of the highest concentrations for each isoflavone category was associated with a 0.09-fold decreased risk for gastric cancer compared with the combination of the lowest concentrations for each category. There was no association between plasma lignan concentrations and gastric cancer.Conclusions: High serum concentrations of isoflavones were associated with a decreased risk for gastric cancer.Impact: These results suggest a beneficial effect of high soybean product intake for gastric cancer risk. Cancer Epidemiol Biomarkers Prev; 19(5); 1292–300. ©2010 AACR.
Effect of Baseline Breast Density on Breast Cancer Incidence, Stage, Mortality, and Screening Parameters: 25-Year Follow-up of a Swedish Mammographic Screening
Authors: Chiu Sherry Yueh-Hsia , Duffy Stephen , Yen Amy Ming-Fang , Tabár Laszlo , Smith Robert A. , Chen Hsiu-Hsi 
Published: May 2010

AbstractBackground: We aimed to quantitatively assess the effect of baseline breast density on the incidence, stage, and mortality, and also the natural course of the disease, considering the sensitivity of mammography to clarify its causal or masking effect.Methods: In total, 15,658 women ages 45 to 59 years from the Kopparberg randomized controlled trial in Sweden were prospectively followed from 1977 until 2004 to ascertain breast cancer incidence and death. Dense breast tissue collected at the beginning of the study was defined as pattern IV or V by the Tabár classification. Conventional risk factors were also collected at baseline. The three-state Markov model was used to estimate the preclinical incidence rate and the mean sojourn time given the fixed sensitivity.Results: Dense breast tissue was significantly associated with breast cancer incidence [relative risk (RR) = 1.57 (1.18-1.67)] and with breast cancer mortality [RR = 1.91 (1.26-2.91)] after adjusting for other risk factors. Cumulative incidence rates irrespective of nonadvanced and advanced breast cancer were higher in dense breast tissue compared with nondense tissue but no difference in survival was detected between dense and nondense breast tissue. Dense breast tissue had a higher preclinical incidence rate (causal effect) and shorter mean sojourn time (masking effect) compared with nondense breast tissue by controlling the sensitivity of mammography.Conclusion: We corroborated the effect of baseline breast density with a higher incidence and mortality and also showed its contribution to a masking effect with long-term follow-up data.Impact: Results suggest that the screening policy with a predominantly shorter screening interval and with alternative imaging techniques might be indicated in women with dense breast tissue. Cancer Epidemiol Biomarkers Prev; 19(5); 1219–28. ©2010 AACR.
Meat Mutagens and Breast Cancer in Postmenopausal Women—A Cohort Analysis
Authors: Wu Kana , Sinha Rashmi , Holmes Michelle D. , Giovannucci Edward , Willett Walter , Cho Eunyoung 
Published: May 2010

Abstract
Background: Mutagenic compounds produced when meats are cooked at high temperatures have been hypothesized to increase risk of breast cancer.
Methods: We examined the association between intakes of the heterocyclic amines (HCA) MeIQx (2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline), PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine), DiMeIQx (2-amino-3,4,8-trimethylimidazo[4,5-f]), and meat-derived mutagenic (MDM) activity and risk of breast cancer using a cooking method questionnaire administered in 1996 in the Nurses' Health Study. Between 1996 and 2006, 2,317 breast cancer cases were diagnosed during 533,618 person-years.
Results: Higher intake of HCAs or MDM was not associated with elevated risk of breast cancer [multivariate relative risk and 95% confidence interval for the highest versus lowest quintile: MeIQx: 0.90 (0.79-1.03); PhIP: 0.92 (0.80-1.05); DiMeIQx: 0.92 (0.80-1.05); and MDM: 0.98 (0.85-1.12)]. HCA or MDM was not associated with estrogen receptor–positive/progesterone receptor–positive breast cancer risk either. There was some suggestion of a decreased risk of estrogen receptor–negative/progesterone receptor–negative breast cancer with higher intakes of MeIQx, DiMeIQx, and PhIP, but none of the associations were statistically significant. There was little evidence for an interaction between intake of cruciferous vegetables and HCA or MDM intake and risk of breast cancer.
Conclusion: Higher consumption of mutagens from meats cooked at higher temperature and longer duration was not associated with increased risk of postmenopausal breast cancer.
Impact: Overall prospective data including results from our study do not provide support for a substantial increase in risk of breast cancer with higher intake of HCAs. Cancer Epidemiol Biomarkers Prev; 19(5); 1301–10. ©2010 AACR.
Plasma Organochlorine Levels and Risk of Non–Hodgkin Lymphoma in the Nurses' Health Study
Authors: Laden Francine , Bertrand Kimberly A. , Altshul Larisa , Aster Jon C. , Korrick Susan A. , Sagiv Sharon K. 
Published: May 2010

Abstract
Numerous studies have reported positive associations of environmental exposure to polychlorinated biphenyls (PCB) and p,p′-dichlorodiphenyldichloroethylene (p,p′-DDE) with the risk of non–Hodgkin lymphoma (NHL). In a case-control study nested within the Nurses' Health Study, a prospective cohort of U.S. women, we measured concentrations of PCBs and p,p′-DDE in blood samples from 145 women diagnosed with NHL at least 6 months after blood draw and 290 age- and race-matched controls. We used conditional logistic regression to estimate the odds ratios and 95% confidence intervals for each quartile of exposure relative to the lowest quartile. We also evaluated these associations for major histologic subtypes of NHL. There was no consistent evidence of an association of p,p′-DDE, total PCBs, immunotoxic, or individual PCB congeners with risk of NHL. These results do not support the hypothesis of a positive association between PCB exposure and development of NHL. Cancer Epidemiol Biomarkers Prev; 19(5); 1381–4. ©2010 AACR.
Differences in Albuminuria Between Hispanics and Whites: An Evaluation by Genetic Ancestry and Country of Origin
Authors: Peralta Carmen A. , Li Yongmei , Wassel Christina , Choudhry Shweta , Palmas Walter , Seldin Michael F. , Risch Neil , Siscovick David , Arnett Donna , Psaty Bruce , Shlipak Michael G. 
Published: May 2010

Background—
Reports show higher prevalence of albuminuria among Hispanics compared with whites. Differences by country of origin or genetic background are unknown.

Methods and Results—

In Multi-Ethnic Study of Atherosclerosis, we studied the associations of both genetic ancestry and country of origin with albumin to creatinine ratio among 1417 Hispanic versus white participants using multivariable linear regression and back transforming beta coefficients into relative difference (%RD, 95% CI). Percentage European, Native American, and African ancestry components for Hispanics were estimated using genetic admixture analysis. The proportions of European, Native American, and African genetic ancestry differed significantly by country of origin (
P
<0.0001); Mexican/Central Americans had the highest Native American (41±13%), Puerto Ricans had the highest European (61±15%), and Dominicans had the highest African (39±21%) ancestry. Hispanic ethnicity was associated with higher albumin/creatinine ratio compared with whites, but the association varied with the country of origin (adjusted
P
interaction=0.04). Mexican/Central Americans and Dominicans had higher albumin/creatinine ratio compared with whites after adjustment (RD 19%, 2% to 40% and RD 27%, 1% to 61%), but not Puerto Ricans (RD 8%, −12% to 34%). Higher Native American ancestry was associated with higher albuminuria after age and sex adjustment among all Hispanics (RD 11%, 1% to 21%) but was attenuated after further adjustment. Higher European ancestry was independently associated with lower albumin/creatinine ratio among Puerto Ricans (−21%, −34% to −6%) but not among Mexican/Central Americans and Dominicans.

Conclusions—
Hispanics are a heterogeneous group with varying genetic ancestry. Risks of albuminuria differ across the country of origin groups. These differences may be due, in part, to differences in genetic ancestral components.
Beyond Abstraction: Marx and the Critique of the Critique of Religion
Authors: Toscano Alberto 
Published: May 2010

AbstractThis article reconsiders Marx’s thinking on religion in light of current preoccupations with the encroachment of religious practices and beliefs into political life. It argues that Marx formulates a critique of the anticlerical and Enlightenment-critique of religion, in which he subsumes the secular repudiation of spiritual authority and religious transcendence into a broader analysis of the ‘real abstractions’ that dominate our social existence. The tools forged by Marx in his engagement with critiques of religious authority allow him to discern the ‘religious’ and ‘transcendent’ dimension of state and capital, and may contribute to a contemporary investigation into the links between capitalism as a religion of everyday life and what Mike Davis has called the current ‘reenchantment of catastrophic modernity’.
Rethinking Venezuelan Politics: Class, Conflict and the Chávez Phenomenon, Steve Ellner, Boulder: Lynne Rienner, 2008. Bush vs. Chávez: Washington’s War on Venezuela, Eva Golinger, New York: Monthly Review Press, 2007. Changing Venezuela by Taking Power: The History and Policies of the Chávez Government, Gregory Wilpert, London: Verso, 2007.
Authors: Donald V. Kingsbury 
Published: May 2010

AbstractAfter a decade in power, Venezuela’s Bolivarian Revolution faces a newly multilateral Washington DC and global capitalism’s most significant crisis in a generation. In order to properly understand the hopes and impediments for the future of the Revolution, I argue, it is first necessary to consider the current trajectory and series of accomplishments it has made. In this review-essay, I consider the three most recent and comprehensive works on the foreign and domestic situations in Venezuela in English ‐ Eva Golinger’s Bush vs Chávez, Gregory Wilpert’s Changing Venezuela by Taking Power, and Steve Ellner’s Rethinking Venezuelan Politics.
Editorial Introduction to the Symposium on Giovanni Arrighi’s Adam Smith in Beijing
Authors: Campling Liam 
Published: May 2010

AbstractGiovanni Arrighi (1937‐2009) was a leading figure in the development of world-systems theory and also contributed to a range of debates in Marxist thought. This symposium engages with Arrighi’s last book, Adam Smith in Beijing, which was the final instalment in his ‘trilogy’, following The Long Twentieth Century (1994) and Chaos and Governance in the Modern World System (with Beverly Silver, 1999). This Editorial Introduction traces the broad trajectory of Arrighi’s ‘trilogy’ and its concern with systemic cycles of accumulation, highlights additional major contributions by Arrighi, and sketches some of the central arguments of the five symposium articles.<xref ref-type="fn" rid="FN0">*</xref>
Beijing between Smith and Marx
Authors: Pradella Lucia 
Published: May 2010

AbstractIn Adam Smith in Beijing, Giovanni Arrighi attempts to outline the possible consequences of the growth of China through a rereading of the work of Adam Smith and a critique of Marx. This article analyses and sheds light on the limits of this reading, upon which Arrighi bases his prediction of a possible peaceful growth in collaboration amongst the various nations within the world-market. It also seeks to identify what makes Marx’s work so timely for the understanding of the contemporary phase of capitalist globalisation, with its escalation of the exploitation of ever more globalised labour-power, and of international competition.<xref ref-type="fn" rid="FN1">1</xref>
Exploring the role of spirituality in self-management practices among older African-American and non-Hispanic White women with chronic conditions
Authors: Shevon Harvey Idethia , Cook Lawanda 
Published: May 2010

Objective: The purpose of this study was to examine the role of spirituality in the self-management of chronic illness among older women with chronic conditions. Methods: A sample of 41 African-American and non-Hispanic White women, of age 66 and older, participated in the process of self-care study. Data were collected from semi-structured interviews and analysed for common themes using the Grounded Theory method. Results: Audiotaped and transcribed interviews identified four categories that emerged to suggest the influence of spirituality in behavioural change and disease management: (1) God’s involvement in illness management; (2) prayer as a mediator; (3) spirituality as a coping mechanism; and (4) the combination of conventional and spiritual practices. Discussion: Older women with various chronic illnesses defined ‘spirituality’ in a broad, holistic way, and the findings suggest that spirituality played a part in documenting the self-management process. Knowledge of spirituality and the role it plays in illness management may assist public health gerontologists in designing effective and culturally appropriate self-management programmes.
Gender differences and clustering pattern of behavioural risk factors for chronic non-communicable diseases: community-based study from a developing country
Authors: Ali Khan Khuwaja  , Muhammad Masood Kadir  
Published: May 2010

Objectives: This study estimates the burden of behavioural risk factors for chronic non-communicable diseases (CNDs) to evaluate the degree of clustering and the differential of these factors by gender in adults. Methods: In a community-based survey, information was obtained about behavioural risk factors for CNDs among 534 adults in Karachi, Pakistan. Chi-square test and odds ratio (OR) with 95% confidence interval (CI) were calculated to evaluate the differences of these factors by gender. Results: Overall, 22.5% of adults had anxiety/depression, 47.8% did not have adequate intake of fruits and vegetables, 60.1% were physically inactive while 49.8% were overweight/obese. More women had anxiety/ depression (OR = 2.1; 95% CI = 1.4—3.1), were physically inactive (OR=2.1; 95% CI = 1.5—3.1) and overweight/ obese (OR= 6.2; 95% CI = 4.3—9.1). On the contrary, greater number of men were found to have inadequate fruit and vegetable consumption (OR = 1.8; 95% CI = 1.3—2.5). Only 1.1% of study subjects had none of the studied risk factors, 16.9% had one while 82% had ≥2 factors. The clustering of these risk factors was significantly higher in women (p<0.001). Discussion: This study shows that almost all of the adults in the study had behavioural risk factors for CNDs and clustering of these factors is very common and significantly higher in women. The tendency of clustering risk factors in individuals provides opportunities to address factors with integrated approaches to prevent/delay the onset of CNDs.
Bringing self-management into clinical view: a qualitative study of long-term condition management in primary care consultations
Authors: Blakeman Tom , Bower Peter , Reeves David , Chew-Graham Carolyn 
Published: May 2010

Objectives: To understand social processes underpinning support for self-management of long-term conditions in primary care. Methods: Comparative analysis of observational and interview data concerning the management of long-term conditions in UK primary-care consultations. Analysis of recordings of primary care consultations (n = 86) was conducted in conjunction with analysis of semi-structured interviews with health professionals (n = 17) and patients (n = 12) living with a long-term condition. Results: A key finding was the infrequency with which self-management topics became legitimate objects for discussion in consultations. Analysis suggested that the maintenance of self—other relations was a prime objective for both patients and professionals, and the introduction of self-management topics threatened this process. Technology and the division of labour among primary-care professionals reinforced this tension. Discussion: In order for self-management support to become embedded and integrated into primary care, interventions concerning long-term condition management need to take into account this tension underpinning care.
Melphalan and prednisone plus thalidomide or placebo in elderly patients with multiple myeloma
Authors: Waage Anders , Gimsing Peter , Fayers Peter , Abildgaard Niels , Ahlberg Lucia , Björkstrand Bo , Carlson Kristina , Dahl Inger Marie , Forsberg Karin , Gulbrandsen Nina , Haukås Einar , Hjertner Øyvind , Hjorth Martin , Karlsson Torbjörn , Knudsen Lene Meldgaard , Nielsen Johan Lanng , Linder Olle , Mellqvist Ulf-Henrik , Nesthus Ingerid , Rolke Jürgen , Strandberg Maria , Sørbø Jon Hjalmar , Wisløff Finn , Juliusson Gunnar , Turesson Ingemar ,   for the Nordic Myeloma Study Group
Published: May 2010

Abstract
In this double-blind, placebo-controlled study, 363 patients with untreated multiple myeloma were randomized to receive either melphalan-prednisone and thalidomide (MPT) or melphalan-prednisone and placebo (MP). The dose of melphalan was 0.25 mg/kg and prednisone was 100 mg given daily for 4 days every 6 weeks until plateau phase. The dose of thalidomide/placebo was escalated to 400 mg daily until plateau phase and thereafter reduced to 200 mg daily until progression. A total of 357 patients were analyzed. Partial response was 34% and 33%, and very good partial response or better was 23% and 7% in the MPT and MP arms, respectively (P < .001). There was no significant difference in progression-free or overall survival, with median survival being 29 months in the MPT arm and 32 months in the MP arm. Most quality of life outcomes improved equally in both arms, apart from constipation, which was markedly increased in the MPT arm. Constipation, neuropathy, nonneuropathy neurologic toxicity, and skin reactions were significantly more frequent in the MPT arm. The number of thromboembolic events was equal in the 2 treatment arms. In conclusion, MPT had a significant antimyeloma effect, but this did not translate into improved survival. This trial was registered at www.clinicaltrials.gov as #NCT00218855.
BISMA - Fast and accurate bisulfite sequencing data analysis of individual clones from unique and repetitive sequences
Authors: Rohde Christian , Zhang Yingying , Reinhardt Richard , Jeltsch Albert 
Published: May 2010

Abstract

Background
Bisulfite sequencing is a popular method to analyze DNA methylation patterns at high resolution. A region of interest is targeted by PCR and about 20-50 subcloned DNA molecules are usually analyzed, to determine the methylation status at single CpG sites and molecule resolution.

Results
The BISMA (Bisulfite Sequencing DNA Methylation Analysis) software for analysis of primary bisulfite sequencing data implements sequencing data extraction and enhanced data processing, quality controls, analysis and presentation of the methylation state. It uses an improved strategy for detection of clonal molecules and accurate CpG site detection and it supports for the first time analysis of repetitive sequences.

Conclusions
BISMA works highly automated but still provides the user full control over all steps of the analysis. The BISMA software is freely available as an online tool for academic purposes for the analysis of bisulfite sequencing data from both unique and repetitive sequences http://biochem.jacobs-university.de/BDPC/BISMA/.
WD-repeat instability and diversification of the Podospora anserina hnwd non-self recognition gene family
Authors: Chevanne Damien , Saupe Sven J , Clavé Corinne , Paoletti Mathieu 
Published: May 2010

Abstract

Background
Genes involved in non-self recognition and host defence are typically capable of rapid diversification and exploit specialized genetic mechanism to that end. Fungi display a non-self recognition phenomenon termed heterokaryon incompatibility that operates when cells of unlike genotype fuse and leads to the cell death of the fusion cell. In the fungus Podospora anserina, three genes controlling this allorecognition process het-d, het-e and het-r are paralogs belonging to the same hnwd gene family. HNWD proteins are STAND proteins (signal transduction NTPase with multiple domains) that display a WD-repeat domain controlling recognition specificity. Based on genomic sequence analysis of different P. anserina isolates, it was established that repeat regions of all members of the gene family are extremely polymorphic and undergoing concerted evolution arguing for frequent recombination within and between family members.

Results
Herein, we directly analyzed the genetic instability and diversification of this allorecognition gene family. We have constituted a collection of 143 spontaneous mutants of the het-R (HNWD2) and het-E (hnwd5) genes with altered recognition specificities. The vast majority of the mutants present rearrangements in the repeat arrays with deletions, duplications and other modifications as well as creation of novel repeat unit variants.

Conclusions
We investigate the extreme genetic instability of these genes and provide a direct illustration of the diversification strategy of this eukaryotic allorecognition gene family.