bluuebunny/crossref_metadata_2025_split huggingface dataset:
Allogeneic CAR T Cell Products Cemacabtagene Ansegedleucel/ALLO-501 in Relapsed/Refractory Large B-Cell Lymphoma: Phase 1 Experience From the ALPHA2/ALPHA Clinical Studies
Authors: Locke Frederick L. , Munoz Javier L. , Tees Michael T. , Lekakis Lazaros J. , de Vos Sven , Nath Rajneesh , Stevens Don A. , Malik Shahbaz A. , Shouse Geoffrey P. , Hamadani Mehdi , Oluwole Olalekan O. , Perales Miguel-Angel , Miklos David B. , Fisher Paul W. , Feng Amy , Navale Lynn , Le Gall John B. , Neelapu Sattva S. 
Published: February 2025

Purpose
Off-the-shelf, allogeneic CD19 chimeric antigen receptor (CAR) T cell products may improve access to treatment versus autologous ones. We report the phase 1 experience of the allogeneic CD19 CAR T-cell product cemacabtagene ansegedleucel (cema-cel) and its predecessor, ALLO-501, in CD19 CAR T-naive patients with relapsed/refractory large B-cell lymphoma (R/R LBCL).

Patients and Methods

In the ALPHA2/ALPHA studies, safety and efficacy of allogeneic CD19 CAR T cells were evaluated in CD19 CAR T treatment-naive patients with R/R LBCL. Patients received healthy donor-derived, human leukocyte antigen–unmatched cema-cel/ALLO-501 following a 3-day lymphodepletion regimen of fludarabine (30 mg/m
2
/day), cyclophosphamide (300 or 500 mg/m
2
/day), and escalating doses of the anti-CD52 monoclonal antibody, ALLO-647.

Results
As of September 26, 2024, 33 CD19 CAR T-naive patients with LBCL (median age, 66 years; median number of prior therapies, 3) received allogeneic CAR T cells. CAR T cell expansion was observed following infusion, with persistence observed up to 4 months. Overall and complete response rates were 58% and 42%, respectively; median duration of response in patients with a complete response was 23.1 months. The most common treatment-emergent adverse events were hematologic toxicities. No cases of graft-versus-host disease, immune effector cell-associated neurotoxicity syndrome, or grade ≥3 cytokine release syndrome were reported.

Conclusion
Allogeneic CD19 CAR T cells demonstrated promising overall and durable complete response rates with a manageable safety profile in CD19 CAR T-naive patients with R/R LBCL, supporting additional evaluation of cema-cel in patients with LBCL.
Organ development in growth‐restricted fetuses in the reduced uterine perfusion pressure rat model: A vascular approach of brain, heart, and kidney
Authors: Alhama‐Riba J. , van Kammen C. M. , Nijholt K. T. , Viveen D. , Amarouchi K. , Shasha D. , Krebber M. M. , Hoebeek F. E. , Lely A. T. , Nijboer C. H. A. , Terstappen F. 
Published: February 2025

AbstractFetal growth restriction (FGR) increases the risk of developing cardiovascular, renal, and neurovascular diseases. An overlapping vascular pathophysiology as a response to chronic hypoxia and circulatory redistribution in utero, might underlie this lifelong burden. This study aims to assess potential vascular detoriations in multiple organs following FGR using the Reduced Uterine Perfusion Pressure (RUPP) rat model. The fetal brain, heart, and kidney were collected (RUPP n = 16 vs. sham n = 13) at embryonic day (E)19 for histological assessment of various aspects of vascular and structural development. Results indicated similar microvascularisation in all organs between the groups. Structural assessment demonstrated a decreased brain area and thickness of the somatosensory cortex and thicker right ventricular wall of the heart (not driven by increased proliferation) in RUPP fetuses, and no differences in renal development. In conclusion, the fetal stage might be too early to detect detoriation in organ vasculature, while this study did reveal subtle alterations in structural development of mostly the brain, followed by the heart with sparing of the kidneys. Potentially compensatory mechanisms may be at play at this fetal stage. Nevertheless, small subclinical adaptations could make the FGR offspring more susceptible for second hits with manifestation at older age.
A non-overwintering urban population of the African fig fly (Diptera: Drosophilidae) impacts the reproductive output of locally adapted fruit flies
Authors: Kohlmeier Pinar , Kohlmeier Philip 
Published: February 2025

Abstract
The African fig fly, Zaprionus indianus (Gupta) (Diptera: Drosophilidae), is a highly invasive species originally from tropical Africa that has rapidly spread across the Americas, first arriving via Brazil and subsequently via Florida. Monitoring efforts have primarily focused on orchards which might underestimate the actual spread of Z. indianus because the species may also thrive in natural habitats, urban areas, and other unmanaged environments that are not routinely surveyed. This study investigates the ability of Z. indianus to establish non-overwintering populations in urban environments and its potential impact on local Drosophila melanogaster (Meigen) (Diptera: Drosophilidae) populations. Over 41 weeks, the presence and population dynamics of Z. indianus were monitored in a residential area in Memphis, Tennessee, alongside D. melanogaster. The study also examined the effects of interspecific competition between these two species through competitive breeding assays. Results show that Z. indianus successfully established a stable population during the summer and fall of 2023 but failed to survive the winter as the Z. indianus population was likely eradicated during the cold weather. Additionally, the presence of Z. indianus was found to reduce the reproductive output of D. melanogaster females, although the impact was less severe compared to intraspecific competition among D. melanogaster. These findings highlight the need for increased monitoring of Z. indianus in urban areas across North America, as such environments may serve as reservoirs facilitating the spread of this pest into agricultural sites.
Thermal conductivity of lunar regolith simulant using a thermal microscope
Authors: Kudo Naoto , Watanabe Shunsuke , Nishi Tsuyoshi , Ohta Hiromichi , Tachikawa Sumitaka , Endo Rie 
Published: February 2025

Abstract
In this study, thermal effusivity distributions of two polished JSC-1A particles, a lunar regolith-simulating material, were measured using a thermal microscope. The results confirmed that the average thermal effusivity of the JSC-1A single particle was approximately half that of the FJS-1 single particle, a different type of lunar regolith-simulating material measured by a similar method. Also, the thermal effusivities of the existing mineral phases of pyroxene and anorthite in the particles were obtained and were comparable to those reported in the literature. A possible reason for the lower thermal conductivity of JSC-1A than that of FJS-1 could be the differences in the ratio of the mineral phases, and phase boundaries between the mineral phases.
Distribution and Specialties of Broadly Versus Narrowly Defined Public Health Nurses Working in Government Settings in the United States, 2022
Authors: Bekemeier Betty , Kett Paula M. , Whitman Greg , Chadwick Kelly , Edmonds Joyce K. 
Published: February 2025

Objectives. To estimate the size of the US governmental public health nurse (PHN) workforce by setting and specialty, including those working outside of health departments. Methods. We used 2022 data from the National Council of State Boards of Nursing, representing 2846 registered nurses (RNs) in almost all states, with weights applied. We examined “setting” and “specialty” of PHNs according to broad and more restricted definitions. Results. Using a broad definition, PHNs in government settings made up 3.7% of the RN workforce, and 1.8% when specialty areas were narrowly defined. These percentages varied by state. PHNs working in public health, school health, and correctional health settings largely indicated their specialty practice areas as public health, school health, and “unspecified” rather than more narrow specialty areas. Conclusions. PHNs are a small proportion of the RN workforce. They consider themselves generalists and can be identified by specialty and when working in governmental settings outside of health departments. Public Health Implications. States with few PHNs may be underserving their communities. Better data are needed to understand specific functions and activities of the PHN workforce. ( Am J Public Health. Published online ahead of print February 13, 2025:e1–e10. https://doi.org/10.2105/AJPH.2024.307950 )
WITHDRAWN: Could Halal Label Enhance Sales?: Indonesian Consumer Behaviour Research
Authors: Setianingrum Any , Deviastri Lily 
Published: February 2025

Abstract

A Muslim is obliged to consume halal products according to the commandments of his religion. To what extent is the halal label a determinant of a Muslim's purchasing decision? This study aims to analyze the extent to which halal-labeled products, compared to other important variables, affect a product's selling power, both partially and simultaneously. The data analysis method used is Structural Equation Modeling (SEM). The study's results indicate that only aspects of product quality and ease of purchase access partially affect consumer satisfaction, while halal label and price aspects do not. Moreover, not all independent variables partially affect purchasing decisions. However, the study's results using the F test showed that the halal label variables, ease of purchase access, and product quality significantly affect satisfaction. Likewise, all independent variables mediated by the satisfaction variable affect the purchasing decision of a product. This means that in addition to the halal label, support for ease of purchase access and quality is also needed to increase consumer satisfaction and purchasing decisions. Research limitations: Respondents are only consumers of 1 cosmetic product, so they do not represent consumer behaviour towards halal products, of which there are many types in Indonesia. The implication is that in addition to the halal label, support for ease of purchase access and quality is also needed to increase consumer satisfaction and purchasing decisions. Value producers must also prioritize product quality, ease of purchasing access, and price, not just the halal label.
JEL Classification: D12, M31, Z12
Symmetry to asymmetry: innovative evolvement of a gas–liquid–solid (GLS) separator in UASB/EGSB reactors on a new perspective
Authors: Hao Feilin , Shen Mingwei 
Published: February 2025

ABSTRACT

The transition from up-flow anaerobic sludge blanket (UASB) reactors to expanded granular sludge bed (EGSB) reactors presents challenges for traditional symmetric critical gas–liquid–solid (GLS) separators, including high spatial occupation, fluid-energy consumption, and reduced separation efficiency. This study introduced a novel GLS separation mechanism based on vortex circulation-induced deposition, agglomeration, and flowback of solid separation. Leveraging this mechanism, an innovative asymmetrical laboratory-scale GLS separator was developed and tested with both granular and flocculent sludge. The new prototype demonstrates superior solid separation performance, achieving 98.3% for granular sludge and 96.0% for flocculent sludge. It features a simple structure and optimized flow paths, resulting in approximately 30% reduction in height and 14.8% less material consumption compared to existing models. Flocculent sludge shows greater sensitivity to operational factors than granular sludge, with higher sludge concentration and smaller fragment size being preferable for high separation efficiency. This mechanism is validated by experimental observations and computational fluid dynamics (CFD) simulations, providing a new perspective on GLS separation and establishing the new model as a promising candidate for UASB/EGSB bio-reactors.
A Polish Composer of Jewish Descent: in Interwar Lwów. Reflections on the National and Religious Identity of Józef Koffler
Authors: Piekarski Michał 
Published: February 2025

Abstract
Józef Koffler (born 1896 in Stryj, died 1943/1944) has so far usually been perceived as a Polish composer of Jewish origin. He was a composer and professor at the PTM Conservatory of Music in Polish Lwów (now Lviv, Ukraine) in the years 1924–1939. This article attempts to analyse his identity against the background of his education, work, professional activity, and circle of acquaintances and friends. The problem deserves attention, especially since the fact that Koffler abandoned Judaism in favour of Christianity before World War II has been completely unknown so far. The composer’s letter of December 1941, especially important in this context, has likewise been unknown. This paper inquires whether baptism influenced Koffler’s career in any way, and whether this decision could have resulted from internal motives. Koffler’s conversion at a rather late age may have been related to his late fatherhood. However, the wish to ensure his son’s full (including religious) assimilation did not necessarily preclude a change in the Koffler couple’s personal beliefs.
Efektivitas Kahoot vs. PowerPoint dalam meningkatkan hasil belajar siswa: Studi kuasi eksperimen
Authors: Faradila Ainis , Saeroji Ahmad 
Published: February 2025

Tujuan penelitian ini adalah untuk mengetahui perbedaan hasil belajar siswa yang menggunakan media PowerPoint dan hasil belajar siswa yang menggunakan media Kahoot. Subjek dalam penelitian ini adalah seluruh siswa kelas XI OTKP di SMK Teuku Umar Semarang. Penelitian ini menggunakan pendekatan kuantitatif dengan jenis penelitian kuasi eksperimen. Metode pengumpulan data menggunakan butir soal pilihan ganda. Metode analisis data menggunakan uji normalitas, uji homogenitas, uji t, dan uji n-gain. Hasil penelitian menunjukkan bahwa nilai rata-rata pre test kelas kontrol sebesar 49,65 dan rata-rata nilai post test sebesar 69,76. Nilai rata-rata pre test kelas eksperimen sebesar 46,71 dan rata-rata nilai post test sebesar 85,65. Terdapat peningkatan hasil belajar (n-gain) pada kelas kontrol sebesar 0,38 sedangkan peningkatan hasil belajar (n-gain) pada kelas eksperimen adalah sebesar 0,72. Kesimpulannya adalah hasil belajar siswa yang menggunakan media Kahoot lebih tinggi daripada hasil belajar siswa yang menggunakan media PowerPoint. Effectiveness of Kahoot vs. PowerPoint in improving student learning outcomes: A quasi-experimental study Abstract: This research aims to determine the different learning outcomes of students who use PowerPoint media and the learning outcomes of students who use Kahoot media. The subjects in this research were all class XI OTKP students at Teuku Umar Vocational School, Semarang. This research uses a quantitative approach with a quasi-experimental type of research. The data collection method uses multiple-choice questions. The data analysis method uses the normality test, homogeneity test, t-test, and n-gain test. The research results showed that the average pre-test score for the control class was 49.65 and the average post-test score was 69.76. The average pre-test score for the experimental class was 46.71 and the average post-test score was 85.65. There was an increase in learning outcomes (n-gain) in the control class of 0.38, while an increase in learning outcomes (n-gain) in the experimental class was 0.72. The conclusion is that the learning outcomes of students who use Kahoot media are higher than the learning outcomes of students who use PowerPoint media.
Demonstration of InGaN full-color monolithic micro-LED display using stacking and selective removal of the light-emitting layer
Authors: Goshonoo Koichi , Okuno Koji , Ohya Masaki 
Published: February 2025

Abstract
A full-color monolithic micro-light-emitting diode (LED) display based on InGaN quantum wells is demonstrated. We stacked red, green, and blue (RGB) light-emitting layers and selectively removed and regrew a p-type layer to create distinct areas on a single chip that emitted RGB colors. Subsequently, we fabricated a full-color monolithic micro-LED chip with a pixel pitch of 30 μm and pixel number of 96 × 96. Each color subpixel emits light with a single peak. We obtained a full-color image by driving the chip using a microcontroller. The proposed semiconductor process-based method enables the fabrication of low-cost and high-resolution microdisplays.
Planets Around Solar Twins/Analogs (PASTA). I. High-precision Stellar Chemical Abundances for 17 Planet-hosting Stars and the Condensation Temperature Trend*
Authors: Sun Qinghui , Wang Sharon Xuesong , Gan Tianjun , Ji Chenyang , Lin Zitao , Ting Yuan-Sen , Teske Johanna , Li Haining , Liu Fan , Hua Xinyan , Tang Jiaxin , Yu Jie , Zhang Jiayue , Badenas-Agusti Mariona , Vanderburg Andrew , Ricker George R. , Vanderspek Roland , Latham David W. , Seager Sara , Jenkins Jon M. , Schwarz Richard P. , Guillot Tristan , Tan Thiam-Guan , Conti Dennis M. , Collins Kevin I. , Srdoc Gregor , Stockdale Chris , Suarez Olga , Zambelli Roberto , Radford Don , Barkaoui Khalid , Evans Phil , Bieryla Allyson 
Published: February 2025

Abstract
The Sun is depleted in refractory elements compared to nearby solar twins, which may be linked to the formation of giant or terrestrial planets. Here we present high-resolution, high signal-to-noise spectroscopic data for 17 solar-like stars hosting planets, obtained with Magellan II/MIKE, to investigate whether this depletion is related to planet formation. We derive stellar parameters, including stellar atmosphere, age, radius, mass, and chemical abundances for 22 elements from carbon to europium through line-by-line differential analysis. Our uncertainties range from 0.01 dex for Fe and Si to 0.08 dex for Sr, Y, and Eu. By comparing the solar abundances to those of the 17 stars, we investigate the differential abundance ([X/Fe]solar–[X/Fe]star) versus condensation temperature (T

c
) trend. In particular, we apply Galactic chemical evolution corrections to five solar twins within the full sample. Our results conform to previous studies that the Sun is relatively depleted in refractory compared to volatile elements. For both five solar twins and the rest of the solar-like stars, we find that all stars hosting known gas giant planets exhibit negative T

c
trend slopes, suggesting that the Sun is relatively depleted in refractory elements compared to similar giant planet-hosting stars. Additionally, we find no correlation between T

c
trend slopes and the total mass of detected terrestrial planets in each system, suggesting that terrestrial planet formation may not be the cause of refractory element depletion in the Sun.
De l’invisibilité à l’hyper-visibilité : « faire image » à partir d’Invisible Man
Authors: Martinière Nathalie 
Published: February 2025

Le roman de Ralph Ellison, Invisible Man (1952) est devenu un classique. La scène inaugurale du Prologue a suscité nombre de commentaires, mais également des reprises ou variations, y compris dans des media différents. Celles de Jeff Wall (intitulée After Invisible Man, the Prologue, by Ralph Ellison) et de Glenn Ligon (Untitled [I am an invisible man]) illustrent toutes deux le potentiel à « faire image » d’un passage dont le titre proclame pourtant l’invisibilité. Les deux œuvres témoignent également de la manière dont le Prologue peut être réinvesti par des imaginaires personnels et des objectifs spécifiques. Elles relèvent de l’appropriation (ou de la ré-vision) plus que de l’illustration ou même de l’adaptation. Dans ces reprises en effet, l’écart inhérent à la transmission intermédiale se double d’un décalage dû à la distance temporelle mais aussi à des partis pris artistiques très différents qui soulignent le processus de sélection à l’œuvre dans la transmission. Ni Wall ni Ligon n’illustrent ce passage du roman : ils le font leur et le soumettent à leur propre grammaire esthétique, remettant finalement en question le rapport texte-image. Chaque œuvre peut alors se lire avec ou sans le Prologue, interrogeant ainsi les enjeux de la transmission et la portée politique de la dialectique « visibilité/invisibilité » posée par Ellison.
Décadence iconique du texte-image dans l’œuvre d’Aubrey Beardsley
Authors: Tonnel Stéphanie 
Published: February 2025

Résumé du mémoire de master lauréat ex aequo du prix de la SAIT (Société Angliciste : Arts, Images, Textes), à laquelle est adossée la revue Polysèmes.
Políticas de lo imposible. La ontología de la comunidad y del prójimo en Slavoj Žižek
Authors: Butierrez Luis 
Published: February 2025

En el siguiente trabajo analizaremos las consideraciones político-sociales en elaboraciones de Slavoj Žižek, desde su apropiación específica de la perspectiva psicoanalítica de Lacan. En especial, buscaremos dar cuenta de la ontología política con la que desarrolla sus críticas de las políticas identitarias, los discursos multiculturalistas y movimientos socio-políticos recientes. En ese marco, distinguiremos sus comprensiones del sujeto y el prójimo, en las respectivas consideraciones sobre las formas de relación con el otro. Por esta vía nos proponemos desarrollar un análisis crítico de las bases con las que articula sus propuestas políticas de emancipación.
Detection and separation methods for resolution of products of enzymatic reactions
Authors: Meyer Elazar 
Published: February 2025

Special analytical methods have been developed for the detection and separation of the resolved products of several kinetic enzymatic resolutions employing enzymes such as lipases and transglutaminase, which are useful as catalysts in nearly anhydrous organic solvents to carry out stereospecific and selective enzymatic resolutions of compounds such as (+/-)-2-bromohexadecanoic acid (2-Br-HDA), (R,S)-mandelic acid, DL-β-phenyllactic acid and (R,S)-2-phenylpropionic acid.
Research on the Evaluation of Henan Province's Construction of National Innovation Highland Level
Authors: Zhang Kai 
Published: February 2025

In recent years, China's rapid economic growth has driven investment expansion at various levels of government, resulting in a continuous increase in local government debt. While local governments often rely on substantial borrowing to meet funding needs in economic development and infrastructure improvement, this accumulation of debt also introduces potential fiscal risks. To effectively prevent and manage these risks and ensure national economic security, China launched a comprehensive government accounting reform in 2019, shifting from the traditional cash-based accounting method to the accrual basis, which better reflects the true financial status of the government. This shift represents a significant improvement in government financial management, enabling a more systematic and transparent presentation of assets, liabilities, revenues, and expenses through the consolidated government financial report. This enhanced transparency not only provides essential data to assess the financial health of local governments but also supports in-depth analysis of debt composition and risk points from perspectives like the balance sheet. Such insights offer a scientific basis for identifying, assessing, and mitigating debt risks, aiding governments in developing more effective debt management strategies, and promoting sustainable fiscal development alongside robust risk control.

Received: 24 September 2024 | Revised: 15 November 2024 | Accepted: 23 January 2025

Conflicts of Interest
The author declares that he has no conflicts of interest to this work.

Data Availability Statement
The data supporting the results of this study can be publicly obtained on the website of the China National Bureau of Statistics at https://www.stats.gov.cn/.

Author Contribution Statement
Kai Zhang: Conceptualization, Methodology, Validation, Investigation, Resources, Data curation, Writing – original draft, Writing – review & editing, Visualization, Supervision, Project administration, Funding acquisition.