bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alterations in microbiome associated with acute pancreatitis
Authors: Yazici Cemal , Priyadarshini Medha , Boulay Brian , Dai Yang , Layden Brian T. 
Published: June 2024

Purpose of review
This review evaluates the current knowledge of gut microbiome alterations in acute pancreatitis, including those that can increase acute pancreatitis risk or worsen disease severity, and the mechanisms of gut microbiome driven injury in acute pancreatitis.

Recent findings
Recent observational studies in humans showed the association of gut microbiome changes (decreased gut microbiome diversity, alterations in relative abundances of certain species, and association of unique species with functional pathways) with acute pancreatitis risk and severity. Furthermore, in-vivo studies highlighted the role of gut microbiome in the development and severity of acute pancreatitis using FMT models. The gut barrier integrity, immune cell homeostasis, and microbial metabolites appear to play key roles in acute pancreatitis risk and severity.

Summary
Large human cohort studies that assess gut microbiome profile, its metabolites and impact on acute pancreatitis risk and severity will be crucial for development of innovative prediction, prevention and treatment strategies.
Atypical facial clefts: Tessier number 3 and 4 clefts
Authors: Civantos Alyssa M. , Shakya Pramila , Shaye David A. 
Published: June 2024

Purpose of review
Tessier number 3 and 4 clefts result from failed fusion of facial processes during embryogenesis, and cause functional, psychosocial, and cosmetic morbidity. Given their rarity and heterogeneity, they present a unique challenge to the reconstructive surgeon, with limited literature for guidance. The purpose of this update is to summarize Tessier number 3 and 4 clefts with a focus on recent literature and expert opinion.

Recent findings
The incidence of atypical facial clefts has been estimated between 1.4 and 4.9 per 100 000 live births. Several retrospective chart reviews have been published in recent years; however, the epidemiologic data remains limited. Surgical management must be individualized and guided by classic reconstructive principles. The goal of surgery is to return the three soft tissue components (lip, nasomalar, and eyelid) to their proper anatomical location.

Summary
Tessier number 3 and 4 clefts are rare, demonstrate a wide spectrum of clinical presentation, and remain challenging to gain a breadth of experience for any single surgeon. They are classified based on their location along well defined anatomical axes. Component repair is performed with attention to the lip, nasomalar, and eyelid regions to restore facial symmetry and function.
The Effect of Real-Time Medication Monitoring-Based Digital Adherence Tools on Adherence to Antiretroviral Therapy and Viral Suppression in People Living With HIV: A Systematic Literature Review and Meta-Analysis
Authors: Msosa Takondwa Charles , Swai Iraseni , Aarnoutse Rob , Rinke de Wit Tobias F. , Ngowi Kennedy , Msefula Chisomo , Nliwasa Marriott , Boer Marion Sumari-de 
Published: June 2024

Background:
Universal antiretroviral therapy (ART) has led to improved treatment outcomes in persons living with HIV. Adherence to ART is required to achieve viral suppression. Real-time medication monitoring (RTMM)–based digital adherence tools (DATs) could be effective in improving ART adherence and viral suppression in persons living with HIV.

Objectives:
The primary and secondary objectives of this review were to assess the effect of RTMM-based DATs on improving ART adherence and viral load suppression.

Methods:
We searched MEDLINE, Embase, and Global Health for publications published through October 11, 2022. Narrative synthesis and random effects meta-analyses were conducted to synthesize the results.

Results:
Of 638 papers identified, 8 were included. Six studies were randomized controlled trials (RCTs), and 2 were cohort studies. Two studies, an RCT in China (mean adherence: 96.2% vs 89.1%) and a crossover cohort study in Uganda (mean adherence: 84% vs 93%), demonstrated improved ART adherence. No studies demonstrated improved viral suppression. In the meta-analyses, we estimated that RTMM-based digital adherence tools had a statistically insignificant small positive effect on ART adherence and viral suppression with a standardized mean difference of 0.1922 [95% CI: −0.0268 to 0.4112, P-value: 0.0854] and viral suppression with an odds ratio of 1.3148 [95% CI: 0.9199 to 1.8791, P-value: 0.1331].

Conclusions:
Our meta-analyses found that RTMM-based DATs did not have a significant effect on ART adherence and viral suppression. However, due to few published studies available, heterogeneity of target populations, intervention designs, and adherence measurement instruments, more data are required to provide conclusive evidence.
Diabetes is not a negative prognostic factor for 30-days mortality after surgery for acute type A aortic dissection
Authors: Lorenz Veronica , Muzzi Luigi , Neri Eugenio 
Published: June 2024

Background
The correlation between diabetes and aortic dissection is not fully understood yet, although in literature many studies have suggested that there may be an association between the two conditions. The purpose of this study is to evaluate whether diabetes represents a short- and long-term risk factor for mortality from type A acute aortic dissection.

Materials and methods
A total of 340 patients with the diagnosis of type A acute aortic dissection underwent aortic surgery between January 2002 and March 2023. The sample was divided into 2 cohorts according to the presence of diabetes (n = 34) or not (n = 306).

Results
The mean age was 66 (±12.4) years and 60.9% were male. The primary endpoint was 30-day mortality. Hospital mortality was 12 (35.3%) for the diabetes group and 70 (22.9%) for nondiabetes group (P = 0.098). Overall survival at 10 years was 48.3% [95% confidence interval (CI): 41.6–54.7%], while the 10-year survival for people with diabetes was 29.5% (95% CI: 13.2–47.9%) and for nondiabetes group 50.6% (95% CI: 43.4–57.3%) (Log-rank, P = 0.024).

Conclusion
Diabetes was not found to be a risk factor associated with 30-day mortality in patients undergoing surgery for type A acute aortic dissection. It was a risk factor for long-term survival, but this may be related to diabetes complications.
Long-read sequencing reveals the allelic diversity of the self-incompatibility gene across natural populations inPetunia(Solanaceae)
Authors: Maenosono Taiga , Isono Kazuho , Kuronuma Takanori , Hatai Miho , Chimura Kaori , Kubo Ken-ichi , Kokubun Hisashi , Greppi Julián Alejandro , Watanabe Hitoshi , Uehara Koichi , Tsuchimatsu Takashi 
Published: June 2024

AbstractSelf-incompatibility (SI) is a genetic mechanism to prevent self-fertilization and thereby promote outcrossing in hermaphroditic plant species through discrimination of self and non-self pollen by pistils. In many SI systems, recognition between pollen and pistils is controlled by a single multiallelic locus (calledS-locus), in which numbers of alleles (calledS-alleles) are segregating. Because of the extreme level of polymorphism of theS-locus, identifications ofS-alleles have been a major issue in many SI studies for decades. Here we report an RNA-seq-based method to explore allelic diversity of theS-locus by employing the long-read sequencing technology of the Oxford Nanopore MinION, and applied it for the gametophytic SI system ofPetunia(Solanaceae), in which the female determinant is a secreted ribonuclease called S-RNase that inhibits the elongation of self-pollen tubes by degrading RNA. We developed a method to identifyS-alleles by the search ofS-RNasesequences, using the previously reported sequences as queries, and found in total 62 types ofS-RNaseincluding 45 novel types. We validated this method through Sanger sequencing and crossing experiments, confirming the sequencing accuracy and SI phenotypes corresponding to genotypes. Then, using the obtained sequence data together with PCR-based genotyping in a larger sample set of 187 plants, we investigated the diversity, frequency, and the level of shared polymorphism ofS-alleles across populations and species. The method as well as the dataset obtained inPetuniawill be an important basis for further studying the evolution of S-RNase-based gametophytic SI systems in natural populations.Significance statementFlowering plants have evolved molecular mechanisms called self-incompatibility (SI) for discriminating self and non-self pollen at pistils to prevent self-fertilization, which is often deleterious due to inbreeding depression. The specificity of SI is usually determined by numbers of highly divergent alleles (calledS-alleles) segregating at a single locus, and identifications ofS-alleles have been a major issue in many SI systems. Here we report a new method to identifyS-alleles by employing a long-read sequencing technology and applied it for the gametophytic SI system ofPetunia, identifying 62 types ofS-alleles including 45 novel types. The method as well as the dataset obtained in this study will be an important basis for the research of SI evolution.
Quantitative sodium-MRI detects differential sodium content in benign vs. malignant oncocytic renal tumours
Authors: Horvat-Menih Ines , Birchall Jonathan R , Zamora-Morales Maria J , Bebb Alice , Kaggie Joshua D , Riemer Frank , Gill Andrew B , Priest Andrew N , Wylot Marta , Mendichovszky Iosif A , Warren Anne Y , Jones James , Armitage James N , Mitchell Thomas J , Stewart Grant D , McLean Mary A , Gallagher Ferdia A 
Published: June 2024

AbstractBackgroundAccurate non-invasive subtyping of localised kidney tumours is an unmet clinical question in uro-oncology. Differentiation of benign renal oncocytomas (RO) from malignant chromophobe renal cell carcinomas (chRCC) is not possible using conventional imaging. Despite the importance of renal function for sodium regulation, little is known about sodium handling in kidney tumours.PurposeHere we used non-invasive sodium MRI (23Na-MRI) to quantify sodium concentration and relaxation dynamics across a range of different kidney tumour subtypes and have correlated these findings with imaging surrogates for perfusion, hypoxia, and cellularity.Materials and MethodsBetween January and April 2023, patients with localised renal masses were prospectively recruited and underwent23Na and proton (1H) MRI at 3T to acquire 3D maps of B1, total sodium concentration (TSC), proton and sodium relaxation rates (R2*), and diffusion weighted imaging (DWI). Statistical analysis included comparison and correlation of quantified imaging parameters across kidney tumour subtypes.ResultsTen patients were included in the final analysis (mean age±S.D. = 64±8 years; 7:3 male:female ratio) encompassing seven ROs, two chRCCs, two clear cell RCCs (ccRCC), and one papillary RCC (pRCC). The TSC was significantly higher in the ROs compared to the chRCCs: 162±58 mM vs. 71±2 mM (P< 0.05). The mean TSC in ccRCC was 135±59 mM, and 81 mM in pRCC. The23Na-derived and1H-derivedR2* values showed a weak correlation (Spearman r = 0.17;P= 0.50). There was a significant inverse correlation between TSC and1H-R2* (Spearman r = -0.39,P< 0.05), but TSC was independent of the DWI-derived imaging parameters.Conclusion23Na-MRI detected markedly different sodium concentrations within benign ROs and malignant chRCCs. In addition, the sodium signal inversely correlated with1H-R2* as a surrogate for hypoxia. Therefore we have shown the feasibility and potential of23Na-MRI for future research in renal tumours.Key results23Na-MRI was used to non-invasively assess kidney tumour subtypes for the first time.A significantly higher total sodium concentration was detected in benign renal oncocytoma (162±58 mM), compared to chromophobe renal cell carcinoma (71±2 mM), as the malignant counterpart:P< 0.05.Total sodium concentration showed a significant inverse correlation with1H-R2* (Spearman r = -0.39,P< 0.05), but it was independent of the diffusion-weighted imaging-derived parameters.Summary statement23Na-MRI showed potential for differentiating benign and malignant masses, to characterise kidney tumours, which may be linked to the underlying differences in deoxygenation as measured with1H-MRI.
Multi-ancestry genome-wide association study of neutrophil-lymphocyte ratio and polygenic risk score development to explore causal association with diabetic retinopathy
Authors: Lathika Rajendrakumar Aravind , Narayanan Nair Anand Thakarakkattil , Chourasia Mehul Kumar , Nangia Charvi , Srinivasan Sundararajan , Radha Venkateshan , Anjana Ranjit Mohan , Siddiqui Moneeza K , Meng Weihua , Mohan Viswanathan , Palmer Colin N A 
Published: June 2024

AbstractBackgroundNeutrophil–lymphocyte Ratio(NLR) is a biomarker of inflammation and was associated with diabetic retinopathy (DR) in earlier studies.ObjectiveTo investigate the genetic loci influencing NLR and to estimate the heritability and causality of DR with the NLR polygenic risk score (PRS).DesignGenome-wide association study, conditional analysis, Fine and Gray model (FGR), Mendelian Randomization (MR)SettingScottish and South Indian populations drawn from population cohorts and electronic medical records.Participants29,317 individuals, with a considerable proportion diagnosed with diabetes.MeasurementsEffect estimates from GWAS to compute PRS and causal association with DR.ResultsHeritability estimates for the Scottish and Indian cohorts were 35.3% and 8.7% respectively. The top Single Nucleotide Polymorphisms (SNPs) in the multi-ancestry analysis (n=29,317) were intergenic: rs1825819 (Chr4:T/C) (Beta=-0.05, p=2.00×10-9), rs2980871 (Chr8:A/G) (Beta=0.04, p=4.64×10-8), rs2227322 (Chr17:C/G) (Beta=0.07, p=4.12×10-20) and rs4808047 (Chr19:T/C) (Beta= - 0.07, p=5.93×10-12). For the construction of best-fit PRS, we used 74,377 of 55,333,12 variants. There was a dose-response relationship between the PRS and NLR. The subhazard ratio (sHR) for NLR PRS association with DR was not statistically significant sHR=1.01 (95% CI: 0.97, 1.06, p=0.48). Null associations were observed in both cross-sectional and time-based MR analyses for PRS with DR.LimitationsA substantial proportion of the dataset was used for training the PRS algorithm. Due to trans-ancestry differences, PRS and subsequent analysis were conducted only in the Scottish cohorts.ConclusionsMultiple novel intergenic SNP associations were discovered, complementing those previously identified. Of these, some SNPs were also associated with genes known to regulate white blood cells, but not specifically NLR. More studies are required to confirm the causality between systemic inflammation and DR.Primary Funding SourceNational Institute for Health Research, Pioneer and Leading Goose R&D Program of Zhejiang 2023, and the Ningbo International Collaboration Program 2023.
Negative charge-transfer energy in
SrFeO3
revisited with hard x-ray photoemission spectroscopy
Authors: Takegami D. , Nakamura M. , Melendez-Sans A. , Fujinuma K. , Nakamura R. , Yoshimura M. , Tsuei K.-D. , Tanaka A. , Gen M. , Tokunaga Y. , Ishiwata S. , Mizokawa T. 
Published: June 2024

We report hard x-ray photoelectron spectroscopy on SrFeO3 which is one of the classical conducting transition-metal oxides with a noncollinear magnetic structure. The obtained spectra show a detailed charge-transfer (CT) satellite structure, the Fe 2p3/2 main peak exhibits multiplet splitting, and the deterioration signs present in previous reports are absent here, allowing for a better determination of its intrinsic electronic structure. The results are well described by a FeO6 cluster model with a charge-transfer energy of about −1.0 eV, confirming the values obtained in the previous works. The negative CT energy indicates that the electronic configuration of the tetravalent Fe is d5L rather than d4 where L represents an O 2p hole. The small spectral weight observed at the Fermi level indicates the correlated metallic state with localized Fe 3d electrons and mobile O 2p holes which are governed by a large d−d Coulomb interaction and negative CT energy.

Published by the American Physical Society
2024
Comment on “Fusion-fission dynamics of
Pt188,190
through fission fragment mass distribution measurements”
Authors: Caamaño M. 
Published: June 2024

Kavita [] analyze the width of the mass distributions of fission fragments from Si28+Gd160 and C12+Hf178 collisions. The authors report that the distributions “are reproducible with a single Gaussian at all studied energies”. However, the fits presented in the figures show functions that do not correspond to single-Gaussian distributions. A critical analysis, presented here, sheds doubts on the characterization of the mass distributions.

Published by the American Physical Society
2024
Effect of wind on quadrotor battery consumption
Authors: Ercan Hamdi , Ulucan Hamdi , Kılıç Şekibe 
Published: June 2024

Purpose
The advancements in battery technologies, while trailing behind technological progress, face challenges meeting the soaring energy demands of quadrotors, resulting in flight durations that are far from satisfactory. Hence, this study aims to empirically investigate the impact of wind on battery consumption.

Design/methodology/approach
Flight tests were conducted using the Pixhawk 4 along identical flight paths and durations. In these flight tests, the quadrotor was exposed to different wind speeds.

Findings
The amount of energy consumed in the flight tests was examined. It has been observed that wind poses a serious threat to battery consumption and thus flight safety.

Practical implications
It is predicted that the data obtained from these studies will be useful in the battery and route selection of quadrotors used in many areas in the future.

Originality/value
This experimental investigation involved conducting numerous flight trials at diverse wind speeds under genuine atmospheric conditions. The energy consumption data acquired holds significance as it directly mirrors real-world scenarios encountered in practical applications.
Computational investigation of the aerodynamic performance of an optimised alternative fuselage shape
Authors: Odendaal Diwan U. , Smith Lelanie , Craig Kenneth J. , Sanders Drewan S. 
Published: June 2024

Purpose
The purpose of this study is to re-evaluation fuselage design when the main wing’s has the ability to fulfill stability requirements without the need for a tailplane. The aerodynamic requirements of the fuselage usually involve a trade-off between reducing drag and providing enough length for positioning the empennage to ensure stability. However, if the main wing can fulfill the stability requirements without the need for a tailplane, then the fuselage design requirements can be re-evaluated. The optimisation of the fuselage can then include reducing drag and also providing a component of lift amongst other potential new requirements.

Design/methodology/approach
A careful investigation of parameterisation and trade-off optimisation methods to create such fuselage shapes was performed. The A320 Neo aircraft is optimised using a parameterised 3D fuselage model constructed with a modified PARSEC method and the SHERPA optimisation strategy, which was validated through three case studies. The geometry adjustments in relation to the specific flow phenomena are considered for the three optimal designs to investigate the influencing factors that should be considered for further optimisation.

Findings
The top three aerodynamic designs show a distinctive characteristic in the low aspect ratio thick wing-like aftbody that has pressure drag penalties, and the aftbody camber increased surface area notably improved the fuselage’s lift characteristics.

Originality/value
This work contributes to the development of a novel set of design requirements for a fuselage, free from the constraints imposed by stability requirements. By gaining insights into the flow phenomena that influence geometric designs when a lift requirement is introduced to the fuselage, we can understand how the fuselage configuration was optimised. This research lays the groundwork for identifying innovative design criteria that could extend into the integration of propulsion of the aftbody.
Relationship between workplace ostracism and job productivity: the mediating effect of emotional exhaustion and lack of motivation
Authors: Ibrahim Raed , Olaleye Banji Rildwan 
Published: June 2024

PurposeDrawing on the transactional theory of stress and coping, this paper aims to identify the relationship between workplace ostracism and job productivity by analyzing the mediating role of emotional exhaustion and lack of motivation.Design/methodology/approachWe collected data from a sample of 396 employees from 20 manufacturing companies in Jordan using a survey-based, two-tiered approach. The partial least squares structural equation modeling method was used to test the direct and indirect effects of ostracism on productivity.FindingsThe findings show that workplace ostracism increases emotional exhaustion and motivation, and indirectly decreases job productivity through the mediating role of emotional exhaustion and lack of motivation.Originality/valueThe study provides a theoretical foundation on which various companies can base their understanding of workplace ostracism and its relationship to job productivity. By focusing on increased exhaustion and lack of motivation, this study analyzes current literature to establish the impacts on areas of interest and identify expectations in the context of productivity, as well as enhance comprehension of the detrimental effects of workplace ostracism on productivity.
A case study and empirical examination of creating a new premium new energy vehicle brand by NIO
Authors: Yang Yiweng , Zhang Hui , Tao Xiaobo , Ji Xuehong , Li Jipeng 
Published: June 2024

PurposeThe purpose is to investigate how to create a new premium new energy vehicle brand.Design/methodology/approachThis study employed a two-stage design. Firstly, a single-case study of NIO was undertaken to execute a thematic analysis, from which propositions were proposed and a theoretical model was constructed. Subsequently, quantitative data were collected through the questionnaire method to empirically test the model developed in the first stage.FindingsNIO creates great user experience through four aspects: product, service, digital touchpoints and lifestyle. Functional experience is shaped by product and digital touchpoints, while emotional experience is affected by service and lifestyle. NIO wins extremely high user satisfaction through great user experience. User satisfaction is affected by both functional and emotional experience. Taking extremely satisfied users as the core, NIO leverages word-of-mouth recommendations to increase brand awareness and build premium brand image, so as to achieve high performance in the long term.Originality/valueThis study contributes to the literature by proposing and testing a theoretical model of creating a new premium new energy vehicle brand. It highlights the significance of emotional factors in the process of creating a new premium brand. It proposes employing the “ripple model” to translate user satisfaction into financial performance. It provides a three-step guide to creating a new premium brand for managers.