bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leadership, sourcing modes and IT project management
Authors: Roy Vital , Bernier Carmen , Danis Martin 
Published: August 2010

AbstractInformation technology (IT) project management has always been a major concern for firms. Researchers have demonstrated that the different characteristics of a project directly affect project management practices and have suggested that different leadership profiles are better suited to different project conditions. The aim of the proposed model is to aid in the understanding of the relationship between the type of IT project (represented by its sourcing mode) and the leadership profile adopted by a project manager. Using a case approach, we studied four successful IT projects. Our results suggest that projects using a partnership or recuperation sourcing mode require a more flexible profile of management than projects characterized by internal governance or outsourcing, which require a more control‐oriented profile of management. Copyright © 2010 ASAC. Published by John Wiley & Sons, Ltd.
“Work is my passion”: The different affective, behavioural, and cognitive consequences of harmonious and obsessive passion toward work
Authors: Forest Jacques , Mageau Geneviève A. , Sarrazin Claude , Morin Estelle M. 
Published: August 2010

AbstractThis study applies the dualistic model of passion (Vallerand et al., 2003) to the work setting and examines the relationships between harmonious passion (characterized by a strong but controllable desire to engage in an activity), obsessive passion (characterized by an internal pressure to carry out an activity), and optimal functioning outcomes at work. Harmonious passion associated positively with: mental health; three elements of flow (i.e., concentration, control, and autotelic experience); vitality, and affective commitment. These relationships were partly mediated by satisfaction of the basic psychological needs of autonomy, competence, and relatedness. In contrast, obsessive passion directly and negatively predicted mental health and weakly but positively predicted autotelic experience. Theoretical and applied implications are discussed. Copyright ©2010 ASAC. Published by John Wiley & Sons, Ltd.
Dynamic Treatment Response of Olive Mills Wastewater Using Series of Adsorption Steps
Authors: Azzam Mohammed‐Osama J. , Al‐Malah Kamal , Al‐Gazzawi Ziad , Al‐Omari Saad A. 
Published: August 2010

AbstractOlive mills wastewater (OMW) is a critical environmental problem in the Mediterranean area due to its extremely high levels of COD and phenols. In this study, a group of adsorption experiments were conducted to investigate the dynamic response of the pH, COD, phenols, TSS, TDS, and TS concentrations of pretreated OMW, using different concentrations of activated carbon as adsorbent. The pretreatment included sedimentation and filtration of OMW. The pretreated OMW was then subjected to adsorption. A series of adsorption steps in stirred batch vessels were studied, namely, one stage, two‐stage countercurrent, and three‐stage countercurrent adsorption systems. A combined two‐ two‐stage countercurrent adsorption steps were also studied. Experimental results showed that such treatment protocols were promising. For example, a treatment protocol composed of a three‐stage countercurrent adsorption process using activated carbon of concentration of 24 g/L of OMW was able to reduce the COD from 60 000 mg/L down to 22 300 mg/L, while phenols were reduced from 450 to 15 mg/L.
Removal of Cadmium from Aqueous Solution Using Castor Seed Hull: A Kinetic and Equilibrium Study
Authors: Sen Tushar Kanti , Mohammod Masita , Maitra Saikat , Dutta Binay K. 
Published: August 2010

AbstractThe effects of various parameters such as initial concentration, adsorbent loading, pH, and contact time on kinetics and equilibrium of adsorption of Cd2+ metal ion from its aqueous solution by castor seed hull (CSH) and also by activated carbon have been investigated by batch adsorption experiments. The amount of adsorption increases with initial metal ion concentration, contact time, solution pH, and the loading of adsorbent for both the systems. Kinetic experiments indicate that adsorption of cadmium metal ion on both CSH and on activated carbon consists of three steps – a rapid adsorption of cadmium metal ion, a transition phase, and an almost flat plateau region. This has also been confirmed by the intraparticle diffusion model. The lumped kinetic results show that the cadmium adsorption process follows a pseudo‐second order rate law. The kinetic parameters including the rate constant are determined at different initial metal ion concentrations, pH, amount, and type of adsorbent, respectively. The Langmuir and Freundlich adsorption isotherm models are used to describe the experimental data. The Langmuir model yields a better correlation coefficient than the other model. A comparison of the monolayer adsorption capacity (qm) of CSH, activated carbon, and several other reported adsorbents has been provided. The value of separation factor (RL) calculated from the Langmuir equation also gives an indication of favorable adsorption of the metal ion. From comparative studies, it has been found that CSH is a potentially attractive adsorbent than commercial activated carbon for cadmium metal ion (Cd2+) removal.
Modeling and Optimization of Fluoride and Cadmium Trapping in Phosphogypsum Using Design Methodology
Authors: Hajem Besma , Djebali Kais , M'nif Adel 
Published: August 2010

AbstractThe manufacturing of phosphoric acid from natural calcium phosphate generates a solid residue containing 25–30% humidity. This solid residue (phosphogypsum) generates acidic solution (pH ≈ 2.5) containing several toxic ionic species, that coat its grains. Fluorides and heavy metals such as cadmium are considered the most harmful species contained in the released solution from phosphogypsum. The purpose of this work is to study the trapping of fluorides and cadmium in phosphogypsum as well as effluent neutralization before its discharge into natural recipient. Therefore, calcium carbonate finely ground was added and fully mixed with wet phosphogypsum. A four factors central composite design was used to model and to optimize the operating parameters that govern the process. The studied factors were temperature, reaction time, mass, and grains size of CaCO3. Considered responses were pH, F−, and Cd2+ concentrations in the released solution after reaction with CaCO3. The optimum operating conditions were quite efficient to trap, respectively, 99% Cd2+ and 97% of F− with a final pH of 6.66. So an original, easy, simple, and cost effective method to trap some toxic species on phosphogypsum through CaCO3 addition would likely to be integrated in phosphoric acid manufacturing plant.
The actin gene family: Function follows isoform
Authors: Perrin Benjamin J. , Ervasti James M. 
Published: August 2010

AbstractAlthough actin is often thought of as a single protein, in mammals it actually consists of six different isoforms encoded by separate genes. Each isoform is remarkably similar to every other isoform, with only slight variations in amino acid sequence. Nevertheless, recent work indicates that actin isoforms carry out unique cellular functions. Here, we review evidence drawn from localization studies, mouse models, and biochemical characterization to suggest a model for how in vivo mixing of actin isoforms may influence cytoskeletal function in cells. © 2010 Wiley‐Liss, Inc.
Dynamic regulation of sarcomeric actin filaments in striated muscle
Authors: Ono Shoichiro 
Published: August 2010

AbstractIn striated muscle, the actin cytoskeleton is differentiated into myofibrils. Actin and myosin filaments are organized in sarcomeres and specialized for producing contractile forces. Regular arrangement of actin filaments with uniform length and polarity is critical for the contractile function. However, the mechanisms of assembly and maintenance of sarcomeric actin filaments in striated muscle are not completely understood. Live imaging of actin in striated muscle has revealed that actin subunits within sarcomeric actin filaments are dynamically exchanged without altering overall sarcomeric structures. A number of regulators for actin dynamics have been identified, and malfunction of these regulators often result in disorganization of myofibril structures or muscle diseases. Therefore, proper regulation of actin dynamics in striated muscle is critical for assembly and maintenance of functional myofibrils. Recent studies have suggested that both enhancers of actin dynamics and stabilizers of actin filaments are important for sarcomeric actin organization. Further investigation of the regulatory mechanism of actin dynamics in striated muscle should be a key to understanding how myofibrils develop and operate. © 2010 Wiley‐Liss, Inc.
The Abl and Arg non‐receptor tyrosine kinases regulate different zones of stress fiber, focal adhesion, and contractile network localization in spreading fibroblasts
Authors: Peacock Justin G. , Couch Brian A. , Koleske Anthony J. 
Published: August 2010

AbstractDirected cell migration requires precise spatial control of F‐actin‐based leading edge protrusion, focal adhesion (FA) dynamics, and actomyosin contractility. In spreading fibroblasts, the Abl family kinases, Abl and Arg, primarily localize to the nucleus and cell periphery, respectively. Here we provide evidence that Abl and Arg exert different spatial regulation on cellular contractile and adhesive structures. Loss of Abl function reduces FA, F‐actin, and phosphorylated myosin light chain (pMLC) staining at the cell periphery, shifting the distribution of these elements more to the center of the cell than in wild‐type (WT) and arg−/− cells. Conversely, loss of Arg function shifts the distribution of these contractile and adhesion elements more to the cell periphery relative to WT and abl−/− cells. Abl/Arg‐dependent phosphorylation of p190RhoGAP (p190) promotes its binding to p120RasGAP (p120) to form a functional RhoA GTPase inhibitory complex, which attenuates RhoA activity and downstream pMLC and FA formation. p120 and p190 colocalize both in the central region and at the cell periphery in WT cells. This p120:p190 colocalization redistributes to a more peripheral distribution in abl−/− cells and to a more centralized distribution in arg−/− cells, and these altered distributions can be restored to WT patterns via re‐expression of Abl or Arg, respectively. Thus, the altered p120:p190 distribution in the mutant cells correlates inversely with the redistribution in adhesions, actin, and pMLC staining in these cells. Our studies suggest that Abl and Arg exert different spatial regulation on actomyosin contractility and focal adhesions within cells. © 2010 Wiley‐Liss, Inc.
Effect of TBCD and its regulatory interactor Arl2 on tubulin and microtubule integrity
Authors: Tian Guoling , Thomas Simi , Cowan Nicholas J. 
Published: August 2010

AbstractAssembly of the α/β tubulin heterodimer requires the participation of a series of chaperone proteins (TBCA‐E) that function downstream of the cytosolic chaperonin (CCT) as a heterodimer assembly machine. TBCD and TBCE are also capable of acting in a reverse reaction in which they disrupt native heterodimers. Homologs of TBCA‐E exist in all eukaryotes, and the amino acid sequences of α‐ and β‐tubulin isotypes are rigidly conserved among vertebrates. However, the efficiency with which TBCD effects tubulin disruption in vivo depends on its origin: bovine (but not human) TBCD efficiently destroys tubulin and microtubules upon overexpression in cultured cells. Here we show that recombinant bovine TBCD is produced in HeLa cells as a stoichiometric cocomplex with β‐tubulin, consistent with its behavior in vitro and in vivo. In contrast, expression of human TBCD using the same host/vector system results in the generation of TBCD that is not complexed with β‐tubulin. We show that recombinant human TBCD functions indistinguishably from its nonrecombinant bovine counterpart in in vitro CCT‐driven folding reactions, in tubulin disruption reactions, and in tubulin GTPase activating protein assays in which TBCD and TBCC stimulate GTP hydrolysis by β‐tubulin at a heterodimer concentration far below that required for polymerization into microtubules. We conclude that bovine and human TBCD have functionally identical roles in de novo tubulin heterodimer assembly, and show that the inability of human TBCD to disrupt microtubule integrity upon overexpression in vivo can be overcome by siRNA‐mediated suppression of expression of the TBCD regulator Arl2 (ADP ribosylation factor‐like protein). © 2010 Wiley‐Liss, Inc.
Structure–Activity Relationships and Molecular Docking of Novel Dihydropyrimidine‐Based Mitotic Eg5 Inhibitors
Authors: Prokopcová Hana , Dallinger Doris , Uray Georg , Kaan Hung Yi Kristal , Ulaganathan Venkatasubramanian , Kozielski Frank , Laggner Christian , Kappe C. Oliver 
Published: August 2010

AbstractDihydropyrimidine‐based compounds belong to the first discovered inhibitors of the human mitotic kinesin Eg5. Although they are used by many research groups as model compounds for chemical genetics, considerably less emphasis has been placed on the improvement of this type of inhibitor, with the exception of two recent studies. Dihydropyrimidines can be divided into class I (analogues that bind in the S configuration) and class II type inhibitors, which bind in the R configuration. Herein we report the synthesis and optimization of novel class II type dihydropyrimidines using a combination of in vitro and docking techniques.
α‐Ketoheterocycles as Inhibitors of Leishmania mexicana Cysteine Protease CPB
Authors: Steert Koen , Berg Maya , Mottram Jeremy C. , Westrop Gareth D. , Coombs Graham H. , Cos Paul , Maes Louis , Joossens Jurgen , Van der Veken Pieter , Haemers Achiel , Augustyns Koen 
Published: August 2010

AbstractCysteine proteases of the papain superfamily are present in nearly all eukaryotes and also play pivotal roles in the biology of parasites. Inhibition of cysteine proteases is emerging as an important strategy to combat parasitic diseases such as sleeping sickness, Chagas disease, and leishmaniasis. Inspired by the in vivo antiparasitic activity of the vinylsulfone‐based cysteine protease inhibitors, a series of α‐ketoheterocycles were developed as reversible inhibitors of a recombinant L. mexicana cysteine protease, CPB2.8. Three isoxazoles and especially one oxadiazole compound are potent reversible inhibitors of CPB2.8; however, in vitro whole‐organism screening against a panel of protozoan parasites did not fully correlate with the observed inhibition of the cysteine protease.
Prevalence, predictors, and characteristics of off‐treatment fatigue in breast cancer survivors
Authors: Andrykowski Michael A. , Donovan Kristine A. , Laronga Christine , Jacobsen Paul B. 
Published: August 2010

AbstractBACKGROUND:Lack of consensus regarding how to identify cancer patients with significant fatigue has hampered research regarding cancer‐related fatigue (CRF).METHODS:Specific criteria were used to identify CRF cases in women with stage 0‐II breast cancer (BC group, n = 304). Women completed assessments before adjuvant therapy (baseline), end of adjuvant therapy (Post‐Tx), and 6 and 42 months after end of adjuvant therapy (6 and 42 Month Post‐Tx). At each, women completed a clinical interview and questionnaires assessing physical and mental health. A healthy control (HC) group with no history of BC (n = 337) completed 2 similar assessments 36 months apart.RESULTS:Off‐treatment CRF prevalence was 9% and 13% at the 6 and 42 Month Post‐Tx assessments, respectively. Thus, 15% of the sample evidenced off‐treatment CRF with 7% evidencing delayed onset CRF. CRF at the 6 Month Post‐Tx assessment was associated only with CRF at baseline (OR = 3.2) and Post‐Tx assessments (OR = 3.9). CRF at the 42 Month Post‐Tx assessment was associated with CRF at the Post‐Tx assessment (OR = 6.1), obesity at baseline, and several baseline measures of coping in response to fatigue. Off‐treatment CRF cases differed markedly from CRF noncases and healthy controls on a spectrum of health status indices (mean effect size >1.0 SD).CONCLUSIONS:Results document the prevalence of off‐treatment and delayed onset CRF, suggest the utility of a cognitive‐behavioral model of CRF, and support NCCN guidelines recommending monitoring fatigue across the cancer trajectory. Cancer 2010. © 2010 American Cancer Society.
Cognitive impairment in men with testicular cancer prior to adjuvant therapy
Authors: Wefel Jeffrey S. , Vidrine Damon J. , Veramonti Tracy L. , Meyers Christina A. , Marani Salma K. , Hoekstra Harald J. , Hoekstra‐Weebers Josette E. H. M. , Shahani Lokesh , Gritz Ellen R. 
Published: August 2010

AbstractBACKGROUND:Cognitive dysfunction experienced by individuals with cancer represents an important survivorship issue because of its potential to affect occupational, scholastic, and social activities. Whereas early efforts to characterize cognitive dysfunction primarily focused on the effects of chemotherapy, more recent evidence indicates that impairment may exist before systemic treatment. This study characterized cognitive dysfunction before adjuvant chemotherapy in a sample of men diagnosed with nonseminomatous germ cell tumors (NSGCT) of the testis.METHODS:Men with newly diagnosed NSGCT were recruited after orchiectomy but before adjuvant chemotherapy. Patients completed neuropsychological tests to assess attention, learning, language, executive function, and motor function. Self‐report measures of depression and anxiety were also administered. An overall cognitive function index was computed for participants. Cognitive impairment was defined as a z‐score of less than or equal to −1.5 on 2 or more tests, or a z‐score of less than or equal to −2.0 on a single test.RESULTS:Approximately 46% of patients exhibited cognitive impairment at the time of assessment, which is significantly greater than would be expected considering healthy population norms (binomial test: P < .0001). Patients exhibited impairments in motor function, verbal learning, and executive function much more frequently relative to normative expectations (binomial test: P < .0001).CONCLUSIONS:The prevalence of cognitive impairment in men with newly diagnosed NSGCT is unexpectedly high before the receipt of adjuvant chemotherapy. Efforts to track cognitive function over time and to develop effective interventions are warranted. Cancer 2011. © 2010 American Cancer Society.
Association of PAI‐1 gene polymorphism with survival and chemotherapy‐related vascular toxicity in testicular cancer
Authors: de Haas Esther C. , Zwart Nynke , Meijer Coby , Suurmeijer Albert J.H. , Meijer Karina , Guchelaar Henk‐Jan , Hoekstra Harald J. , van Leeuwen Flora E. , Sleijfer Dirk Th. , Boezen H. Marike , Gietema Jourik A. 
Published: August 2010

AbstractBACKGROUND:High Plasminogen‐Activator Inhibitor 1 (PAI‐1) expression by tumors has been associated with poor prognosis in several cancer types, and high systemic PAI‐1 levels with increased thrombosis risk. The authors investigated whether the germline 4G/5G deletion/insertion polymorphism in the PAI‐1 promoter (rs1799889), which may influence PAI‐1 expression, is associated with survival and chemotherapy‐related vascular toxicity in testicular cancer (TC).METHODS:Data were collected on PAI‐1 4G/5G polymorphism, survival, venous thromboembolism (VTE), and coronary heart disease (CHD) for 324 non‐seminomatous TC patients treated with platinum‐based chemotherapy. Genotypes were compared regarding survival and disease outcome. VTE and CHD incidence were compared with adjustment for cardiovascular risk factors and prothrombotic gene polymorphisms of coagulation factors II/prothrombin (G20210A) and V (G1691A).RESULTS:The 4G/4G variant of PAI‐1 4G/5G polymorphism shows a higher prevalence of International Germ Cell Cancer Classification (IGCCC) poor prognosis compared with 4G/5G and 5G/5G (24% vs 8% and 15%; chi‐square P = .003). In addition, the 4G/4G variant shows reduced TC‐related survival with a hazard ratio of 2.69 (95% CI, 1.26‐5.73; P = .010) for TC‐related death (adjusted for IGCCC). This is related to an increased risk for refractory disease and early relapses (odds ratio, 3.35; 95% CI, 1.48‐7.59; P = .004). PAI‐1 4G/5G polymorphism is not associated with VTE and CHD risk.CONCLUSIONS:The 4G/4G variant of PAI‐1 4G/5G polymorphism may be an unfavorable prognostic as well as predictive factor for response to chemotherapy in TC patients. If confirmed, it may contribute to the identification of patients with increased risk for refractory disease. Cancer 2010. © 2010 American Cancer Society.
Genetic variants in one‐carbon metabolism‐related genes contribute to NSCLC prognosis in a Chinese population
Authors: Jin Guangfu , Huang Jinlin , Hu Zhibin , Dai Juncheng , Tang Rong , Chen Yijiang , Xu Lin , Huang Xinen , Shu Yongqian , Shen Hongbing 
Published: August 2010

AbstractBACKGROUND:One‐carbon metabolism plays a critical role in DNA methylation and DNA synthesis. Variants of genes involved in one‐carbon metabolism may result in aberrant methylation and/or DNA synthesis inhibition, and ultimately modulate the initiation and progression of tumors. In this study, the authors hypothesized that polymorphisms in one‐carbon metabolism‐related genes may contribute to the prognosis of nonsmall cell lung cancer (NSCLC).METHODS:The authors screened 57 potentially functional single nucleotide polymorphisms (SNPs) from 11 candidate genes involved in one‐carbon metabolism and genotyped them in a cohort of 568 NSCLC patients by using Illumina Golden Gate platform. The Kaplan‐Meier method with log‐rank test and Cox proportional hazards model were used for survival analyses.RESULTS:Variant alleles were significantly associated with favorable survivals of NSCLC for MTR rs3768160 A>G (allelic hazards ratio [HR], 0.78; 95% confidence interval [CI], 0.62‐0.98), MTRR rs2966952 G>A (allelic HR, 0.84; 95% CI, 0.71‐0.99) and DHFR rs1650697 G>A (allelic HR, 0.83; 95% CI, 0.70‐0.99) and with unfavorable prognosis for MTHFD1 rs1950902 G>A with borderline significance (allelic HR, 1.18; 95% CI, 0.99‐1.40). In addition, the combined genotypes of these four SNPs showed a locus‐dosage effect on NSCLC survival (Ptrend = 6.9 × 10−5). In the final multivariate Cox regression model, combined genotypes based on 3 categories may be an independent prognostic factor for NSCLC with adjusted trend HR of 0.78 (95% CI, 0.66‐0.92).CONCLUSION:Genetic variants in one‐carbon metabolism pathway may be candidate biomarkers for NSCLC prognosis. Cancer 2010. © 2010 American Cancer Society.