bluuebunny/crossref_metadata_2025_split huggingface dataset:
Telemedicine impact on patient disparities and physician practice patterns in cancer rehabilitation: A multicenter retrospective study
Authors: Leong David , Ng Amy , Chang Philip , Zheng Jasmine , Wilson Richard , Chen Matthew Edwin , Vargo Mary 
Published: June 2024

AbstractObjectiveTo examine the impact of telemedicine on demographic and practice patterns between outpatients receiving virtual versus in‐person cancer rehabilitation physiatry care.DesignMulticenter retrospective study.SettingOutpatient cancer rehabilitation physiatry clinics at four academic medical centers in the United States.PatientsPatients with cancer diagnoses or history of cancer diagnosis.InterventionsCancer rehabilitation physiatry encounters.Main Outcome MeasuresVisit mode (in‐person, telemedicine); disparities variables (age, race, and gender) by visit mode, and practice interventions (imaging, medications, procedures, other orders, and orders of any type) by visit mode.ResultsAmong a total of 7004 encounters, 2687 unique patients were found. In‐person participants were significantly older than the average telemedicine participant (mean 62.9 vs. 60.7 years; p < .001). A race effect was seen (p = .037) with individuals reporting as Asian or other being more likely to have telemedicine encounters. No gender disparities were seen. Using a random visit analysis model to compare populations receiving in‐person versus telemedicine care, a slight majority (53%) of follow‐up visits were via telemedicine, versus 40% of new patient visits (p < .001). No significant differences were seen in medication prescribing frequency (38.9% telemedicine vs. 36.7% in‐person, adjusted relative risk [RR]: 0.988, confidence interval [CI]: 0.73–1.34; p = .988) or imaging frequency (2.4% telemedicine vs. 7.6%; adjusted RR: 0.784, CI: 0.44–1.39; p = .408) between telemedicine versus in‐person visit types. Other orders were significantly less likely to be placed during telemedicine than in‐person visits (19.9% telemedicine vs. 28.6% in‐person; adjusted RR: 0.623, CI: 0.45–0.86, p = .004). Order(s) of any type were placed in 54% of visits (52% telemedicine vs. 56% in‐person; adjusted RR: 0.92 for telemedicine, CI: 0.83–1.01, p = .082).ConclusionsTelemedicine has been integrated into cancer rehabilitation physiatry practices and appears to be conducive for placing many types of orders, especially medications. Age was found to be the only major demographic difference between in‐person and telehealth patients.
Rhodamine‐based force‐sensitive organic polysiloxane for hardness recognition of inorganic particles
Authors: Wu Yifan , Xia Yangguang , Yuan Ye , Dou Ziyi , Kan Chenqun , Zhang Na , Wang Taisheng 
Published: June 2024

AbstractThe mechanochromic materials can respond to environmental changes by altering the optical properties of the system, which has garnered significant attention in recently. The utilization of these materials for the purpose of sensing tensile and compressive stress has been extensively documented. However, the mechanochromic polymer that can effectively discriminate hardness of inorganic particles is still rarely reported. In this article, a force‐sensitive organic polysiloxane was developed by introducing triethenyl‐substituted rhodamine derivatives crosslinker into the polymethylhydrosiloxane network through hydrosilylation addition reaction. The results demonstrated that the grinding of the crosslinked polysiloxane effectively facilitated the transmission of external force to the polymeric network, leading to an open ring isomerization of rhodamine accompanied by significant alterations in visible and fluorescent color. In addition, we found that the optical properties of the system showed distinct variations when the inorganic particles with different Moh's hardness were co‐ground with the polysiloxane. High Moh's hardness particles, such as Al2O3, could effectively trigger the mechanochromic behavior of the polymer, while Na2SO4 particles with low hardness failed to induce the corresponding change. Therefore, this organic polysiloxane could be used as a potential fluorescent indicator for hardness recognition.
Kinetic isotope effect reveals rate‐limiting step in green‐to‐red photoconvertible fluorescent proteins
Authors: Breen Bella , Whitelegge Julian P. , Wachter Rebekka M. 
Published: June 2024

AbstractPhotoconvertible fluorescent proteins (pcFPs) undergo a slow photochemical transformation when irradiated with blue light. Since their emission is shifted from green to red, pcFPs serve as convenient fusion tags in several cutting‐edge biological imaging technologies. Here, a pcFP termed the Least Evolved Ancestor (LEA) was used as a model system to determine the rate‐limiting step of photoconversion. Perdeuterated histidine residues were introduced by isotopic enrichment and chromophore content was monitored by absorbance. pH‐dependent photoconversion experiments were carried out by exposure to 405‐nm light followed by dark equilibration. The loss of green chromophore correlated well with the rise of red, and maximum photoconversion rates were observed at pH 6.5 (0.059 ± 0.001 min−1 for red color acquisition). The loss of green and the rise of red provided deuterium kinetic isotope effects (DKIEs) that were identical within error, 2.9 ± 0.9 and 3.8 ± 0.6, respectively. These data indicate that there is one rate‐determining step in the light reactions of photoconversion, and that CH bond cleavage occurs in the transition state of this step. We propose that these reactions are rate‐limited on the min time scale by the abstraction of a proton at the His62 beta‐carbon. A conformational intermediate such as a twisted or isomerized chromophore is proposed to slowly equilibrate in the dark to generate the red form. Additionally, His62 may shuttle protons to activate Glu211 to serve as a general base, while also facilitating beta‐elimination. This idea is supported by a recent X‐ray structure of methylated His62.
California provider and advocate perspectives about opportunities to optimize nutrition services and resources in the first 1000 days
Authors: Lindsay Karen L. , Robertson Trina , Leka Helen , Rosales Ashley , Smilowitz Jennifer T. , Lucas Candice Taylor 
Published: June 2024

AbstractBackgroundNutrition in the first 1000 days of life, from conception to age 2 years, plays a critical role in shaping offspring's physical and mental development, yet many families from underserved backgrounds suffer from nutrition inequity during this important stage of development. The objective of this study is to assess nutrition services and resources provided to families during the first 1000 days across diverse settings in California.MethodsA semistructured survey was disseminated to healthcare and educational providers who offer services to pregnant and/or postpartum women and children up to age 2 years. Perspectives about five domains of early‐life nutrition services and resources were assessed: (1) accessibility, (2) mode of content delivery, (3) content of messages, (4) breastfeeding support, and (5) professional development on early‐life nutrition. Mixed methodology was used to conduct descriptive and thematic analyses for closed and open‐ended survey questions, respectively.ResultsSurvey respondents (n = 148) worked in healthcare (37%), governmental (20%), community (20%), and childcare settings (23%). Over 60% primarily served low‐income families. Less than 9% reported that their organizations provide prenatal nutrition messaging about critical micronutrients required to support foetal neurodevelopment, highlighting an opportunity for professional development training in nutrition. Need for equitable access to nutrition education and resources by addressing
Language,
Income,
Food resources,
Time and
Transportation (LIFTT) was a cross‐cutting theme that emerged.ConclusionProviders perceive a need to enhance LIFTT accessibility and improve delivery of early‐life nutrition‐related services for families in the first 1000 days by providing topic‐specific education and culturally responsive resources with consistent, evidence‐based messages.
Air‐Stable Na3.5C6O6 as a Sodium Compensation Additive in Cathode of Na‐Ion Batteries
Authors: Cao Mengyan , Xu Liang , Guo Yujie , Li Yixin , Fang Qiu , Liu Yuan , Bai Rui , Zhu Jiacheng , Gao Yurui , Cheng Tao , Li Jifang , Wang Xuefeng , Guo Yuguo , Wang Zhaoxiang , Chen Liquan 
Published: June 2024

AbstractSodium‐ion battery (SIB) is a candidate for the stationary energy storage systems because of the low cost and high abundance of sodium. However, the energy density and lifespan of SIBs suffer severely from the irreversible consumption of the Na‐ions for the formation of the solid electrolyte interphase (SEI) layer and other side reactions on the electrodes. Here, Na3.5C6O6 is proposed as an air‐stable high‐efficiency sacrificial additive in the cathode to compensate for the lost sodium. It is characteristic of low desodiation (oxidation) potential (3.4–3.6 V vs. Na+/Na) and high irreversible desodiation capacity (theoretically 378 mAh g−1). The feasibility of using Na3.5C6O6 as a sodium compensation additive is verified with the improved electrochemical performances of a Na2/3Ni1/3Mn1/3Ti1/3O2ǀǀhard carbon cells and cells using other cathode materials. In addition, the structure of Na3.5C6O6 and its desodiation path are also clarified on the basis of comprehensive physical characterizations and the density functional theory (DFT) calculations. This additive decomposes completely to supply abundant Na ions during the initial charge without leaving any electrochemically inert species in the cathode. Its decomposition product C6O6 enters the carbonate electrolyte without bringing any detectable negative effects. These findings open a new avenue for elevating the energy density and/or prolonging the lifetime of the high‐energy‐density secondary batteries.
Strategic Buried Defect Passivation of Perovskite Emitting Layers by Guanidinium Chloride for High‐Performance Pure Blue Perovskite Light Emitting Diodes
Authors: Do Jung Jae , Jung Jae Woong 
Published: June 2024

AbstractPerovskite light‐emitting diodes (PeLEDs) show promise for high‐definition displays due to their exceptional electroluminescent properties. However, the performance of pure blue PeLEDs is hindered by the unfavorable ionic behavior of halides and the presence of defective antisites in blue‐emitting perovskite materials. An unstable buried interface between charge transport layers and the perovskite emitting layer is a major issue that limits carrier transport and recombination behavior in PeLEDs. In this study, effective buried defect passivation of pure blue perovskite emitting layers by introducing guanidinium chloride (GACl) as a bottom‐passivating layer is demonstrated. The GACl bottom layer not only passivates the point defects present at the buried interface but also provides chloride anions to suppress ion migration and halide vacancy formation. Along with the defect passivation, GACl also enforces phase purity of 2D layered structure in the perovskite emitting layers to improve crystallinity and optoelectronic properties. As a result, the PeLEDs with high brightness (1200 cd m−2) and excellent external quantum efficiency (6.61%) are achieved at a spectrally stable pure blue electroluminescence at 471 nm (band width = 17.63 nm). This study offers insights into the straightforward way for effective buried passivation for preparing high‐performance PeLEDs.
Lithium Tris(Oxalato)Aaluminate and its Hydrates: Structure, Dehydration and Thermal Decomposition
Authors: Missyul Alexander , Kreuzer Martin , Usoltsev Oleg , Arsentev Maxim , Chislov Mikhail 
Published: June 2024

AbstractThe double oxalates MI3[MIII(C2O4)3] possess rich crystallochemistry and can be used as precursors for various ceramic materials. The article discusses a case of Li3[Al(C2O4)3]. A series of previously unknown hydrates (Li3[Al(C2O4)3] ⋅ 5.5H2O, Li3[Al(C2O4)3] ⋅ 4H2O, Li3[Al(C2O4)3] ⋅ H2O) was found for this composition, their crystal structure and temperatures of mutual transformations determined. Transformation from Li3[Al(C2O4)3] ⋅ 4H2O to Li3[Al(C2O4)3] ⋅ H2O was found to be accompanied by a change in the topology of the bonding network. Uniaxial negative thermal expansion was found for anhydrous Li3[Al(C2O4)3]. Thermal decomposition of Li3[Al(C2O4)3] was demonstrated to be a promising way to obtain precursors for aluminate ceramics.
Dynamic Coordination Behavior of a Structurally Constrained, Nucleophilic Sn(II) Towards Gold(I)
Authors: Ruppert Heiko , Schreyer Till , Dietl Martin C. , Rudolph Matthias , Hashmi A. Stephen K. , Greb Lutz 
Published: June 2024

AbstractTetradentate meso‐octaalkylcalix[4]pyrroles are well‐established ligands in d‐ and f‐block chemistry. In contrast to the related porphyrins, the sp3‐hybridized meso‐carbon atoms linking the four pyrrole units result in highly divers coordination modes. We previously reported on the combination of this ligand system with Sn(II) centers yielding tetracoordinated stannate(II) anions which could be employed as electron‐rich, strong σ‐donor ligands in transition metal chemistry. With this work we are extending the coordination chemistry of meso‐octaethylcalix[4]pyrrolato stannate(II) [1]2− onto gold(I). Synthesis of mono‐ and dinuclear gold complexes reveal a new dynamic binding mode involving μ2‐bridging coordination of a pyrrole nitrogen atom to both Sn and Au. Single‐crystal X‐ray diffraction and variable temperature NMR spectroscopy combined with quantum mechanical computations and bond analysis tools shed light on the involved intermediates.
Pulmonary artery intimal sarcoma: Case report of a patient managed with multimodality treatment and a comprehensive literature review
Authors: Atahan C. , Güral Z. , Yücel S. , Ağaoğlu F. 
Published: June 2024

AbstractPulmonary artery intimal sarcoma (PAIS) is a rare and aggressive malignancy originating from the intimal layer of the pulmonary artery with poor prognosis due to its aggressive nature. The management of PAIS poses both diagnostic and therapeutic challenges. It presents with nonspecific symptoms and is often misdiagnosed as pulmonary embolism. While surgical resection is the primary treatment modality, the role of adjuvant chemotherapy and radiotherapy remains uncertain. However, given the high recurrence rate, adjuvant chemotherapy and/or radiotherapy have been utilized in a limited number of case reports. We present the case of a 46-year-old woman who was diagnosed with PAIS and underwent surgical resection followed by adjuvant chemotherapy (ChT) and radiotherapy (RT), demonstrating good tolerance to this multimodal treatment approach.
Minimum Cut in $$O(m\log ^2 n)$$ Time
Authors: Gawrychowski Paweł , Mozes Shay , Weimann Oren 
Published: June 2024

AbstractWe give a randomized algorithm that finds a minimum cut in an undirected weighted m-edge n-vertex graph G with high probability in $$O(m \log ^2 n)$$

O
(
m

log
2

n
)

time. This is the first improvement to Karger’s celebrated $$O(m \log ^3 n)$$

O
(
m

log
3

n
)

time algorithm from 1996. Our main technical contribution is a deterministic $$O(m \log n)$$

O
(
m
log
n
)

time algorithm that, given a spanning tree T of G, finds a minimum cut of G that 2-respects (cuts two edges of) T.
Birds do not use social learning of landmarks to locate favorable nest sites
Authors: Slagsvold Tore , Wiebe Karen L. 
Published: June 2024

AbstractExperiments since the classic studies of Niko Tinbergen have provided evidence that animals use visual landmarks to navigate. We tested whether birds use visual landmarks to relocate their nest sites by presenting two species of cavity nesting birds with a dyad of nest boxes with different white markings around the entrance, a circle or a triangle. When the two boxes were erected in close proximity on the same tree, pied flycatchers Ficedula hypoleuca and blue tits Cyanistes caeruleus confused the entrance of their nest both when the boxes had different external markings and when they were unmarked. Most females added nest material to both boxes of a dyad and one third of the flycatchers laid eggs in both boxes although a female can only incubate the eggs in one nest at a time. Thus, the birds did not use external markings around cavity entrances for orientation. We also tried to replicate a previous study purporting to show that migratory birds use social learning of the external appearance of nests from other species. However, pied flycatchers did not choose boxes with the same painted markings as those applied to nests of resident great tits Parus major which were judged to be high quality “demonstrators” from their large clutch sizes. We argue that conclusions from previous studies on social learning based on external markings as landmarks on nest cavities in birds need to be reconsidered.
Morphological and life-history plastic responses to predators and competitors in two brown frogs,Rana dalmatina and R. Latastei
Authors: Castellano Sergio , Seglie Daniele , Friard Olivier 
Published: June 2024

AbstractPredation and competition are two major factors that drive natural selection. When they vary unpredictably, selection has promoted the evolution of plastic responses in behavioral, morphological and life-history traits. These responses are not independent of each other and often represent a trade-off between conflicting interests. We conducted a common-garden experiment to study the effects of predation and competition on the morphology and life history of R. dalmatina and R. latastei tadpoles. The experiment used a randomized-block design, where tadpoles were raised either with or without siblings and either with or without predators. Regardless of the treatments, R. dalmatina grew faster, developed proportionally larger tails, proportionally smaller bodies, and completed metamorphosis earlier than R. latastei. Both species developed relatively larger bodies with competitors, and relatively larger tails with predators. While the relative increase in body size with competitors was similar in the two species, the increase in tail size with predators was greater in R. dalmatina, suggesting that this species invested more in defense than R latastei. Competitors delayed metamorphosis in both species and in R. latastei they negatively affected froglet body size and shape. Conversely, predators delayed the metamorphosis only in R. dalmatina. This delay was the long-term cost paid by R. dalmatina for the short-term benefits of developing more effective behavioral and morphological defensive traits.
Obesity is associated with adverse outcomes in primary immune thrombocytopenia - a retrospective single-center study
Authors: Xiao Zhengrui , He Zhiqiang , Nguyen Hieu Liem Le , Thakur Rahul Kumar , Hammami M. Bakri , Narvel Hiba , Vegivinti Charan Thej Reddy , Townsend Noelle , Billett Henny , Murakhovskaya Irina 
Published: June 2024

AbstractThe pathophysiology of immune thrombocytopenia (ITP) involves immune-mediated platelet destruction. The presence of adipose tissue in obese individuals creates an inflammatory environment that could potentially impact the clinical course and outcomes of ITP. However the relationship between obesity and ITP outcomes has not been well described. We evaluated ITP outcomes in 275 patients diagnosed with primary ITP from 2012 to 2022. Patients were categorized into four groups based on their body mass index (BMI) at diagnosis. Female gender was associated with a lower platelet count at the time of diagnosis at any BMI. Patients with high BMI had lower platelet counts at diagnosis and at platelet nadir (p < 0.001), an increased likelihood of requiring therapy (p < 0.001) and requiring multiple lines of therapy (p = 0.032). Non-obese patients who required corticosteroid treatment experienced a longer remission duration compared to obese patients (p = 0.009) and were less likely to be steroid-dependent (p = 0.048). Our findings suggest that obesity may be a significant risk factor for developing ITP and for ITP prognosis. Future studies are needed to evaluate the role of weight loss intervention in improving ITP outcomes.
Performance of MRI for standardized lymph nodes assessment in breast cancer: are we ready for Node-RADS?
Authors: Pediconi Federica , Maroncelli Roberto , Pasculli Marcella , Galati Francesca , Moffa Giuliana , Marra Andrea , Polistena Andrea , Rizzo Veronica 
Published: June 2024

Abstract
Objectives
The Node-RADS score was recently introduced to offer a standardized assessment of lymph node invasion (LNI). We tested its diagnostic performance in accurately predicting LNI in breast cancer (BC) patients with magnetic resonance imaging. The study also explores the consistency of the score across three readers.

Materials and methods
A retrospective study was conducted on BC patients who underwent preoperative breast contrast-enhanced magnetic resonance imaging and lymph node dissection between January 2020 and January 2023. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value were calculated for different Node-RADS cut-off values. Pathologic results were considered the gold standard. The overall diagnostic performance was evaluated using receiver operating characteristic curves and the area under the curve (AUC). A logistic regression analysis was performed. Cohen’s Kappa analysis was used for inter-reader agreement.

Results
The final population includes 192 patients and a total of 1134 lymph nodes analyzed (372 metastatic and 762 benign). Increasing the Node-RADS cut-off values, specificity and PPV rose from 71.4% to 100% and 76.7% to 100%, respectively, for Reader 1, 69.4% to 100% and 74.6% to 100% for Reader 2, and from 64.3% to 100% and 72% to 100% for Reader 3. Node-RADS > 2 could be considered the best cut-off value due to its balanced performance. Node-RADS exhibited a similar AUC for the three readers (0.97, 0.93, and 0.93). An excellent inter-reader agreement was found (Kappa values between 0.71 and 0.83).

Conclusions
The Node-RADS score demonstrated moderate-to-high overall accuracy in identifying LNI in patients with BC, suggesting that the scoring system can aid in the identification of suspicious lymph nodes and facilitate appropriate treatment decisions.

Clinical relevance statement
Node-RADS > 2 can be considered the best cut-off for discriminating malignant nodes, suggesting that the scoring system can effectively help identify suspicious lymph nodes by staging the disease and providing a global standardized language for clear communication.

Key Points

Axillary lymphadenopathies in breast cancer are crucial for determining the disease stage.

Node-RADS was introduced to provide a standardized evaluation of breast cancer lymph nodes.

RADS > 2 can be considered the best cut-off for discriminating malignant nodes.