bluuebunny/crossref_metadata_2025_split huggingface dataset:
Second Look Arthroscopic Findings after Tibial Plateau Leveling Osteotomy
Authors: Hulse Don , Beale Brian , Kerwin Sharon 
Published: April 2010

Objective: To describe the long‐term (range, 2–69 months) arthroscopic appearance of intraarticular structures of the stifle after tibial plateau leveling osteotomy (TPLO).Study Design: Case series.Animals: Dogs (n=63) that had repeat arthroscopic examination of the stifle after TPLO for treatment of a cranial cruciate ligament (CCL) deficient stifle.Methods: Medical records (2002–2008) of dogs that had repeat arthroscopic examination to evaluate intraarticular structures after previous TPLO for treatment of CCL injury. Regions of interest were the CCL, caudal cruciate ligament, articular cartilage, and menisci. Signalment, weight, and time to 2nd look arthroscopy were recorded. Radiographs were reviewed to measure pre‐ and postoperative tibial plateau angle, and craniocaudal limb alignment.Results: There were 17 partial CCL tears with early fiber tearing and 46 stifles with a complete CCL tear or incompetent partial CCL tear. Stifles with an early partial tear had normal to near normal appearance of intraarticular structures. Most dogs with a complete or incompetent partial CCL tear had axial or abaxial grades 3 or 4 articular cartilage abrasion of the medial or lateral femoral condyle.Conclusion: Intraarticular structures appeared normal or near normal in dogs with early fiber tearing (caudolateral or craniomedial fibers). Most dogs that had a partial tear with an incompetent remaining CCL or a completely ruptured CCL had grades 3 or 4 articular cartilage abrasion.Clinical Relevance: Early diagnosis of a CCL injury and treatment by TPLO may be protective against further CCL disruption lending stability to the joint and decreasing the incidence of meniscal injury and articular cartilage damage.
Long‐Term Follow‐Up of Patients with Syncope Evaluated by Head‐Up Tilt Test
Authors: Domenichini Giulia , Diemberger Igor , Biffi Mauro , Martignani Cristian , Valzania Cinzia , Bertini Matteo , Saporito Davide , Ziacchi Matteo , Branzi Angelo , Boriani Giuseppe 
Published: April 2010

Background: Clinicians may be tempted to consider a positive head‐up tilt test (HUTT) an unfavorable prognostic indicator. We investigated whether results of routine HUTT predict long‐term recurrence of syncope. Methods: We analyzed syncope recurrence at long‐term among 107 patients (mean age 51 ± 20 years) receiving HUTT for diagnostic evaluation of unexplained/suspected neurocardiogenic syncope in our Institute. Results: HUTT was positive in 76 patients (vasodepressive response, n = 58; cardioinhibitory, n = 5; mixed, n = 13). During a median follow‐up of 113 months (range, 7–161), 34 (32%) patients experienced recurrence (24 [32%] with positive HUTT during 110 months (7–159); 10 [32%] with negative HUTT during 120 [22–161] months). Actuarial freedom from recurrence at 10 years did not significantly differ for patients with positive/negative test results (after passive/active phases) or with different positive response patterns (vasodepressive, cardioinhibitory, mixed). By contrast, history of >4 syncopes in the 12 months preceding HUTT stratified risk of recurrence, irrespective of HUTT positivity/negativity. At Cox proportional hazards analysis, history of >4 syncopes in the 12 months preceding HUTT was the single independent risk factor for recurrence both in the overall study population (HR, 1.7; 95% CI, 1.07–2.69) and within the subset of patients who tested positive (HR, 1.83; 95% CI, 1.07–3.17). Conclusions: This long‐term follow‐up study reinforces the concept that a positive HUTT should not be considered an unfavorable prognostic indicator; frequency of recent occurrences may be a more valid predictor. Ann Noninvasive Electrocardiol 2010;15(2):101–106
ST‐Segment Resolution Prior to Primary Percutaneous Coronary Intervention Is a Poor Indicator of Coronary Artery Patency in Patients with Acute Myocardial Infarction
Authors: Verouden Niels J. , Haeck Joost D. , Koch Karel T. , Henriques José P. , Baan Jan , Van Der Schaaf René J. , Vis Marije M. , Peters Ron J. , Wilde Arthur A. , Piek Jan J. , Tijssen Jan G. , De Winter Robbert J. 
Published: April 2010

Background: The prognostic value of ST‐segment resolution (STR) after initiation of reperfusion therapy has been established by various studies conducted in both the thrombolytic and mechanic reperfusion era. However, data regarding the value of STR immediately prior to primary percutaneous coronary intervention (PCI) to predict infarct‐related artery (IRA) patency remain limited. We investigated whether STR prior to primary PCI is a reliable, noninvasive indicator of IRA patency in patients with ST‐segment elevation myocardial infarction (STEMI). Methods: The study population consisted of STEMI patients who underwent primary PCI at our institution between 2000 and 2007. STR was analyzed in 12‐lead electrocardiograms recorded at first medical contact and immediately prior to primary PCI and defined as complete (≥70%), partial (70%− 30%), or absent (<30%). Results: In 1253 patients with a complete data set, STR was inversely related to the probability of impaired preprocedural flow (Pfor  trend < 0.001). Although the sensitivity of incomplete (<70%) STR to predict a Thrombolysis in Myocardial Infarction (TIMI) flow of <3 was 96%, the specificity was 23%, and the negative predictive value of incomplete STR to predict normal coronary flow was only 44%. Conclusions: This study establishes the correlation between STR prior to primary PCI and preprocedural TIMI flow in STEMI patients treated with primary PCI. However, the negative predictive value of incomplete STR for detection of TIMI‐3 flow is only 44% and therefore should not be a criterion to refrain from immediate coronary angiography in STEMI patients. Ann Noninvasive Electrocardiol 2010;15(2):107–115
Diagnostic Significance of a Small Q Wave in Precordial Leads V2 or V3
Authors: Katsuno Tetsuya , Hirao Kenzo , Kimura Shigeki , Komura Masatoshi , Haraguchi Go , Inagaki Hiroshi , Hachiya Hitoshi , Isobe Mitsuaki 
Published: April 2010

Background: An abnormal Q wave is usually defined as an initial depression of the QRS complex having a duration of ≥40 ms and amplitude exceeding 25% of the following R wave in any contiguous leads on the 12‐lead electrocardiogram (ECG). However, much smaller Q waves are sometimes recorded on the ECG. This study investigated the diagnostic value of the small Q wave recorded in precordial leads V2 or V3 on the ECG. Methods: We investigated 807 consecutive patients who underwent coronary angiography. A small Q wave was defined as any negative deflection preceding the R wave in V2 or V3 with <40‐ms duration and <0.5‐mV amplitude, with or without a small (<0.1‐mV) slurred, spiky fragmented initial QRS deflection before the Q wave (early fragmentation). ECG and coronary angiographic findings were analyzed. Results: The small Q wave was present in 87 patients. Multiple logistic regression analysis revealed that presence of a small Q wave was a strong independent predictor of any coronary artery stenosis or left anterior descending artery (LAD) stenosis (odds ratio = 2.706, 2.902; P < 0.001, < 0.001, respectively). Conclusion: A small Q wave (<40‐ms duration and <0.5‐mV amplitude) in V2 or V3 with or without early fragmentation significantly predicted the presence of CAD and, especially, significant stenosis in the LAD. Ann Noninvasive Electrocardiol 2010;15(2):116–123
Aspects of Left Ventricular Morphology Outperform Left Ventricular Mass for Prediction of QRS Duration
Authors: Hakacova Nina , Steding Katarina , Engblom Henrik , Sjögren Jane , Maynard Charles , Pahlm Olle 
Published: April 2010

Background: The knowledge of the case‐specific normal QRS duration in each individual is needed when determining the onset, severity and progression of the heart disease. However, large interindividual variability even of the normal QRS duration exists. The aims of the study were to develop a model for prediction of normal QRS complex duration and to test it on healthy individuals. Methods: The study population of healthy adult volunteers was divided into a sample for development of a prediction model (n = 63) and a testing sample (n = 30). Magnetic resonance imaging data were used to assess anatomical characteristics of the left ventricle: the angle between papillary muscles (PMA), the length of the left ventricle (LVL) and left ventricular mass (LVM). Twelve‐lead electrocardiogram (ECG) was used for measurement of the QRS duration. Multiple linear regression analysis was used to develop a prediction model to estimate the QRS duration. The accuracy of the prediction model was assessed by comparing predicted with measured QRS duration in the test set. Results: The angle between PMA and the length of the LVL were statistically significant predictors of QRS duration. Correlation between QRS duration and PMA and LVL was r = 0.57, P = 0.0001 and r = 0.45, P = 0.0002, respectively. The final model for prediction of the QRS was: QRSPredicted= 97 + (0.35 × LVL) − (0.45 × PMA). The predicted and real QRS duration differed with median 1 ms. Conclusions: The model for prediction of QRS duration opens the ability to predict case‐specific normal QRS duration. This knowledge can have clinical importance, when determining the normality on case‐specific basis. Ann Noninvasive Electrocardiol 2010;15(2):124–129
Microvolt T‐Wave Alternans during Holter Monitoring in Children and Adolescents
Authors: Makarov Leonid , Komoliatova Vera 
Published: April 2010

Background: Time‐domain microvolt T‐wave alternans (TWA) has been described as a noninvasive marker of sudden cardiac death in adults. The incidence of TWA in pediatric populations has not been defined well. The aim of the study was to determine peculiarities of TWA in children. Methods: We examined 68 healthy patients—newborns (20) and children in age group of 7–17 years (48)—and 85 pediatric patients: ventricular premature beats—65; dilated cardiomyopathy (DCMP)—2; long QT syndrome (LQTS)—10; Brugada syndrome (BrS)—5, catecholaminergic ventricular tachycardia (CVT)—3. All underwent Holter monitoring (HM) with definition of the peak value of TWA by modified moving average method. Results: In healthy newborns, TWA was 32 ± 8 (12–55) μV (HR 123–156 bmp). In healthy children (7–17 years) it was 30 ± 11 (10–l 55) μV, (HR 64–132 bmp) without any differences between boys and girls. In all group of patients, TWA were significantly higher (P < 0.05) than in healthy. Circadian peak of TWA was found (90%) in a second part of day and at sleep (8%). Among them 60% (LQTS, BrS, and DCPM) had TWA > 55 μV. Conclusion: Time‐domain TWA during HM in children was independent of age, gender, and heart rate. In 94% healthy children, values of TWA do not exceed 55 μV but 20–50% children with cardiac pathology had TWA more than 55 μV. Night circadian type of TWA in diseases with risk of life‐threatening arrhythmias associated with TWA was more than 55 μV. Ann Noninvasive Electrocardiol 2010;15(2):138–144
Implantable Cardioverter‐Defibrillator Shock: Appropriate or Inappropriate?
Authors: Nault Michael A. , McIntyre William F. , Simpson Christopher S. , Redfearn Damian P. , Abdollah Hoshiar , Brennan F. James , Baranchuk Adrian 
Published: April 2010

A 76‐year‐old female with a single chamber implantable cardioverter‐defibrillator implanted for secondary prevention was referred due to multiple discharges. The device was programmed for ventricular tachycardia (VT) detection at 400 ms, fast VT detection at 280 ms, and ventricular fibrillation detection at 320 ms. Antitachycardia pacing (ATP) during charge was enabled. Interrogation revealed a VT episode with a mean cycle length of 270 ms, which was successfully terminated with ATP during charge. Seconds later, the device delivered a shock. This case illustrates the importance of understanding programming algorithms as part of troubleshooting when facing a scenario of device discharge. Ann Noninvasive Electrocardiol 2010;15(2):181–183
The Relationship Between Cesarean Section and Labor Induction
Authors: Wilson Barbara L. , Effken Judith , Butler Richard J. 
Published: April 2010

Abstract Background: Numerous study results vary when analyzing the relationship between labor induction and the likelihood of cesarean delivery; and few have accounted for the multiple influences of maternal sociodemographic characteristics combined with the provider and hospital in subsequent birth outcomes such as cesarean section. Objective: This study evaluated the likelihood of cesarean birth following labor induction while accounting for maternal, hospital, and provider characteristics. Methods: A cross‐sectional retrospective descriptive design using secondary data was employed to determine what variation in cesarean births was due to differences of hospitals, providers, and patients using the Quality Health Outcomes Model (QHOM). Data were partitioned by primiparous and multiparous women. The individual demographic, system, and provider outcomes in all hospitals and single birth center for Maricopa County in 2005 (N=62,816) were analyzed, using both random effects and fixed effects models. Results: For primiparous women, an increased likelihood of cesarean births was associated with medical inductions, maternal age, being Black, and the number of prenatal visits; and less likely in teaching hospitals and women with higher educational attainment. In multiparous women, cesarean births were associated with increased maternal age and medical inductions; and less likely in for‐profit hospitals and following elective induction. Discussion: Labor inductions were associated with an increased likelihood of cesarean sections based on parity, age, race, number of prenatal visits, education, and hospital teaching status and ownership. Because the QHOM emphasizes multiple contextual variables that influence the delivery and outcomes of care, it can prove ideal for the study of birth outcomes following interventions such as the induction of labor. Clinical Relevance: Nurses should be well educated about the risks of elective labor induction prior to term gestation and “elective” cesarean birth.
PAS is optimal for diagnosing onychomycosis
Authors: Barak Orr , Asarch Adam , Horn Thomas 
Published: April 2010

Onychomycosis is a frequently treated fungal infection of the nail plate with morbidity in high‐risk populations. The diagnosis often relies on histopathologic analysis of nail plate specimens with the assistance of special stains. Pathologists utilize periodic acid schiff (PAS) and/or Gomori methenamine silver (GMS) stains to highlight fungi within the nail plate. In a recent study of 51 PAS‐negative nail cases, it was concluded that GMS is superior to PAS in the diagnosis of onychomycosis. We expand on this study by investigating a larger number of PAS‐negative nail clippings determining whether GMS or PAS is superior in highlighting fungi in additional sections. There was no difference in the sensitivity of PAS vs. GMS (4.2 vs. 4.3%, p = 0.57); however, PAS was found to be significantly less expensive by 2.6‐fold. Taken together, these data suggest that the PAS stain is the optimal method for diagnosing onychomycosis.Barak O, Asarch A, Horn T. PAS is optimal for diagnosing onychomycosis.
The molecular skin pathology of familial primary localized cutaneous amyloidosis
Authors: Tanaka Akio , Lai‐Cheong Joey E. , Van Den Akker Peter C. , Nagy Nikoletta , Millington George , Diercks Gilles F. H. , Van Voorst Vader Pieter C. , Clements Suzanne E. , Almaani Noor , Techanukul Tanasit , Hide Michihiro , South Andrew P. , McGrath John A. 
Published: April 2010

Please cite this paper as: The molecular skin pathology of familial primary localized cutaneous amyloidosis. Experimental Dermatology 2010; 19: 416–423.Abstract:  Familial primary localized cutaneous amyloidosis (FPLCA) is an autosomal dominant disorder associated with chronic itching and skin lichenification. In lesional skin, there are apoptotic basal keratinocytes and deposits of amyloid material on degenerate keratin filaments in the upper dermis. The genetic basis of FPLCA involves mutations in the OSMR and IL31RA genes but the disease pathophysiology is not fully understood. In this study, we identified new pathogenic heterozygous missense mutations in the OSMR gene (p.Val631Leu and p.Asp647Tyr) in two Dutch FPLCA families. We then compared gene expression profiles between FPLCA lesional skin (n = 4) and site‐matched control skin (n = 6). There was twofold or greater upregulation of 34 genes and downregulation of 43 genes. Most changes in gene expression (verified by quantitative RT‐PCR) reflected alterations in epidermal differentiation and proliferation consistent with lichenification, but we also noted a reduction in several interfollicular keratinocyte stem cell markers in FPLCA skin. Differences in gene expression were also noted for proteins involved in apoptosis and nerve conduction. Collectively, this study expands the molecular basis of FPLCA and provides new insight into the skin pathology of this condition.
Investigating Association of Three Polymorphisms of Coagulation Factor XIII and Recurrent Pregnancy Loss
Authors: Jeddi‐Tehrani Mahmood , Torabi Raheleh , Mohammadzadeh Afsaneh , Arefi Soheila , Keramatipour Mohammad , Zeraati Hojjat , Zarnani Amir Hasan , Akhondi Mohammad Mehdi , Mahmoudian Jafar , Mahmoudi Ahmad Reza , Zarei Saeed 
Published: April 2010

Citation Jeddi‐Tehrani M, Torabi R, Mohammadzadeh A, Arefi S, Keramatipour M, Zeraati H, Zarnani AH, Akhondi MM, Mahmoudian J, Mahmoudi AR, Zarei S. Investigating association of three polymorphisms of coagulation factor XIII and recurrent pregnancy loss. Am J Reprod Immunol 2010; 64: 212–217Problem  Among important suspected causes of thrombophilia in women with recurrent pregnancy loss (RPL) are the polymorphisms of coagulation factor XIII (FXIII) gene. We performed a case–control study on the association between three polymorphisms of factor XIII (FXIII G103T, FXIII A614T and FXIII C1694T) and RPL in Iranian women.Method of study  DNA samples from peripheral blood of 100 female patients with at least two recurrent abortions, as case group, and 100 healthy women with history of at least two successful deliveries were subjected to PCR‐RFLP, and the frequencies of the polymorphisms were calculated and compared between the two groups.Results  The prevalence of FXIII G103T polymorphism was 29% in the case group and 17% in the control group (P = 0.158). The frequencies of FXIII A614T and FXIII C1694T were 84% and 66% in the case group and 48% and 31% in the control group (P < 0.001 and P < 0.001), respectively. The two latter polymorphisms are associated with RPL in Iranian women and increase the risk of RPL. A correlation was also found between FXIII A614T and FXIII C1694T polymorphisms (P < 0.001).Conclusion  We suggest the evaluation of FXIII A614T and FXIII C1694T polymorphisms in women with RPL.
Pregnancy Complication and Outcome in Women with History of Allergy to Medicinal Agents
Authors: Ohel Iris , Levy Amalia , Zweig Aya , Holcberg Gershon , Sheiner Eyal 
Published: April 2010

Citation Ohel I, Levy A, Zweig A, Holcberg G, Sheiner E. Pregnancy complication and outcome in women with history of allergy to medicinal agents. Am J Reprod Immunol 2010; 64: 152–158Problem  Pregnancy outcome in women with a previous history of drug allergy and the role of drug allergies in adverse pregnancy outcomes is unclear.Method of study  A retrospective cohort study comparing pregnancies of women with and without history of drug allergy was conducted. Data were collected from the computerized perinatal database. A multiple logistic regression model, with background elimination, was constructed to control for confounders.Results  Of 186,443 deliveries, 4.6% (n = 8647) occurred in patients with a history of drug allergy. The following conditions were significantly associated with a history of drug allergy: advanced maternal age, recurrent abortions, fertility treatments, hypertensive disorders, and diabetes mellitus. Using multivariate analysis, with background elimination, history of drug allergy was significantly associated with intrauterine growth restriction (OR = 1.52, CI = 1.3–0.8, P < 0.001) and with preterm delivery (OR = 1.26, CI = 1.14–1.38, P < 0.001).Conclusion  A history of drug allergy is an independent risk factor for intrauterine growth restriction and preterm delivery. Further prospective studies are needed to investigate the nature of this association.
PHYSICOCHEMICAL, NUTRITIONAL AND MICROBIAL QUALITY OF FRESH‐CUT AND FROZEN PAPAYA PREPARED FROM CULTIVARS WITH VARYING RESISTANCE TO INTERNAL YELLOWING DISEASE
Authors: WALL M.M. , NISHIJIMA K.A. , FITCH M.M. , NISHIJIMA W.T. 
Published: April 2010

ABSTRACT Quality, nutritional and microbial analyses were completed for fresh‐cut and frozen papaya cubes prepared from cultivars with varying resistance to internal yellowing (IY) disease caused by the bacterium Enterobacter cloacae. In general, fresh‐cut and frozen papaya retained nutritional and microbial quality, but visual and textural quality declined. Fresh‐cut fruit pretreated with 1% calcium lactate solution were firmer than control fruit, but translucency limited the shelf life of cubes dipped in either water or calcium lactate. Vitamin C content averaged 61.5 mg/100 g and 52.2 mg/100 g for fresh‐cut and frozen fruit, respectively. Vitamin A content was greatest in fresh‐cut “Laie Gold” and “Rainbow” fruit, and averaged 35.1 µg retinol activity equivalents per 100 g for all cultivars. Microbial counts were very low or not detectable for most samples. Among the cultivars resistant to IY, “Rainbow” had the highest vitamin A and sugar contents, and did not develop translucency.PRACTICAL APPLICATIONSThis study provides new nutritional information for fresh‐cut and frozen papaya products that can be included in the U.S. Department of Agriculture National Nutrient Database. Also, data on cultivar attributes may assist processors of fresh‐cut or frozen papaya products in choosing the best cultivars by considering appearance, texture, flavor, nutritional content and microbial quality. The selection of papaya cultivars with resistance to internal yellowing disease will allow processors to produce nutritious value‐added products that conform to food safety guidelines.