bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Digital Interventions on the Treatment Burden of Patients With Chronic Conditions: Protocol for a Systematic Review
Authors: Polus Manria , Keikhosrokiani Pantea , Korhonen Olli , Behutiye Woubshet , Isomursu Minna 
Published: April 2024

Background
There is great potential for delivering cost-effective, quality health care for patients with chronic conditions through digital interventions. Managing chronic conditions often includes a substantial workload required for adhering to the treatment regimen and negative consequences on the patient’s function and well-being. This treatment burden affects adherence to treatment and disease outcomes. Digital interventions can potentially exacerbate the burden but also alleviate it.

Objective
The objective of this review is to identify, summarize, and synthesize the evidence of how digital interventions impact the treatment burden of people with chronic conditions.

Methods
The search, selection, and data synthesis processes were designed according to the PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols) 2015. A systematic search was conducted on October 16, 2023, from databases PubMed, Scopus, Web of Science, ACM, PubMed Central, and CINAHL.

Results
Preliminary searches have been conducted, and screening has been started. The review is expected to be completed in October 2024.

Conclusions
As the number of patients with chronic conditions is increasing, it is essential to design new digital interventions for managing chronic conditions in a way that supports patients with their treatment burden. To the best of our knowledge, the proposed systematic review will be the first review that investigates the impact of digital interventions on the treatment burden of patients. The results of this review will contribute to the field of health informatics regarding knowledge of the treatment burden associated with digital interventions and practical implications for developing better digital health care for patients with chronic conditions.

Trial Registration
PROSPERO CRD42023477605; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=477605

International Registered Report Identifier (IRRID)
DERR1-10.2196/54833
Deenz Multidimensional Schizoid Personality Scale (DMSPS-28): Measuring Multiple Facets of Schizoid Personality
Authors: Dar Deen Mohd 
Published: April 2024

This research paper examines the effectiveness of the Deenz
Multidimensional Schizoid Personality Scale (DMSPS-28) in assessing
various dimensions of schizoid personality among graduate students. The
study involved a sample of 103 participants, comprising 67 males and 36
females. The DMSPS-28, designed to evaluate five key facets of schizoid
personality—social detachment, anhedonia, blunted affect, solitude,
and friendlessness—was employed as the primary assessment instrument.
Utilizing factor analysis, the study scrutinized the data to determine
the reliability and validity of the DMSPS-28. Results indicated
discernible gender differences in schizoid traits, with males exhibiting
heightened tendencies towards social detachment and solitude, while
females displayed elevated levels of anhedonia and blunted affect. The
DMSPS-28 demonstrated a robust level of reliability, with a coefficient
of 0.91, attesting to its consistency in measuring schizoid personality
dimensions.
These findings hold significance for advancing our comprehension of
schizoid personality and affirm the utility of the DMSPS-28 as an
effective tool for assessment.
What Stops Markers from Providing Consistent and Effective Feedback: Lessons from the Enhanced Rubric Method
Authors: Grozev Vladislav H. , Smalley David 
Published: April 2024

The present qualitative research explored the barriers for markers to
provide consistent and effective essay feedback when they used the
Enhanced Rubric Method (ERM) which is a highly structured method for
providing feedback. We identified three categories of barriers -
markers’ underpinning values when providing feedback (different beliefs
as to what is good feedback and empathy with students), personal
differences in feedback provision (preferring certain assessment
criteria and overusing feedback), and discrepant use of the ERM
(learning the Quickmarks and criteria, creating own Quickmarks,
different uses of positive feedback, and increased use of personalised
feedback). These factors suggest that, despite markers’ best intentions
towards students and principles of consistency, specific practical
recommendations are necessary to ensure consistent and effective
feedback across all markers on a given assignment. We provided three
specific recommendations for practitioners, namely, assessing markers’
levels of feedback literacy prior to marking and reassuring markers that
consistent and effective feedback helps students, co-designing the
feedback method with markers, and providing continued targeted training
for markers. Our results, practical, and future research recommendations
can lead practitioners and academics to achieving satisfactory levels of
consistent and effective feedback, can help markers’ professional
development, and can aid student learning.
Keywords: feedback, Quickmarks, values, markers
Secondary anetoderma associated with Molluscum Contagiosum: a case report study
Authors: VALSAINT Christopher Williams , JOSEPH Thaimye , JUSCA Erley kohlz SAINT , SAMSON Yardley Marie Carmelle , Paul Axler Jean 
Published: April 2024

Introduction/Background: Anetoderma is a rare and
benign skin disorder characterized by a loss of elastic tissue in the
mid-dermis. Among the five main types, the secondary form typically
develops in areas of damaged or pathological skin. Understanding the
origin of the anetoderma is pivotal for accurate diagnosis and
management, considering the impact on patient outcomes. Therefore, in
our study, we describe a patient who presented to Hospital of the State
University of Haiti with secondary anetoderma.
Case presentation: Here we present a case study of a
26-year-old male who presented to the dermatology department with a
protruding oval mass located at the lateral third of the posterior right
arm. The patient did not experience any associated symptoms such as
pain, erythema, or tenderness. The mass evolved over 30 months following
the resection by cautery of a molluscum contagiosum (Figure 1). After
the wound had healed, he noticed a hyperchromic macule with a wrinkled
center that evolved overtime, eventually taking on the appearance of a
cystic mass (Figure 2) with wrinkling and a bulged-out appearance.
Routine evaluations were normal. The mass was surgically resected, and
the cutaneous specimen was sent to pathology. The skin fragment measured
2 x 1.9 x 1.5 cm with a raised flaccid area, and the average resection
margin was 0.7 cm. Upon sectioning, the tissue appeared firm and
whitish. The adipose fragment was irregular and measured 1 x 1 x 0.4 cm.
Microscopically, sections of skin including the epidermis and dermis
were observed. Fragments of adipose tissue from the subcutaneous tissue
were also present. The epidermis appeared regular, and the dense
underlying dermis showed a few vessels with a discrete lymphoplasmacytic
infiltrate surrounding them. The clinical and pathological findings
allowed us to confirm the diagnosis of secondary anetoderma. No atypical
changes were observed. Since the resection, the patient has
shown improvement with the incision site now displaying a mild
hypertrophic scar. Regular monitoring and appropriate scar
management has ensured favorable recovery.
Conclusion: This case illustrates the classic presentation of
secondary anetoderma. Based on the available information, it is
recommended to consider the possibility of anetoderma in patients
presenting with skin lesions following molluscum contagiosum or other
skin disorders where the integrity of the underlying elastic tissue is
compromised. Consultation with a dermatologist and additional
investigations, such as skin biopsy, may be necessary to confirm the
diagnosis.
Liraglutide and Exercise Synergistically Attenuate Vascular Inflammation and Enhance Metabolic Insulin Action in Early Diet-induced Obesity
Authors: Liu Jia , W. Aylor Kevin , Liu Zhenqi 
Published: April 2024

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<p>Inflammation-induced vascular insulin resistance is an early event in diet-induced obesity and contributes to metabolic insulin resistance. To examine whether exercise and glucagon-like peptide 1 (GLP-1) receptor agonism, alone or in combination, modulate vascular and metabolic insulin actions during obesity development, we performed a euglycemic insulin clamp in adult male rats after 2 weeks of high-fat diet feeding with either access to running wheel (exercise), liraglutide, or both. Rats exhibited increased visceral adiposity and blunted microvascular and metabolic insulin responses. Exercise and liraglutide alone each improved muscle insulin sensitivity but their combination fully restored insulin-mediated glucose infusion rates. The combined exercise and liraglutide intervention enhanced insulin-mediated muscle microvascular perfusion, reduced perivascular macrophage accumulation and superoxide production in the muscle, attenuated blood vessel inflammation and improved endothelial function, along with increased endothelial nucleus translocation of NRF2 and increased endothelial AMPK phosphorylation. We conclude that exercise and liraglutide synergistically enhance the metabolic actions of insulin and reduce vascular oxidative stress and inflammation in the early stage of obesity development. Our data suggest that early combination use of exercise and GLP-1 receptor agonism might be an effective strategy in preventing vascular and metabolic insulin resistance and associated complications during the development of obesity.</p>
Response of the Soil Organic Matter to Clear-cutting in the Face of Climate Change – a Report from the East Sudety Mountains, South-West Poland
Authors: Jamroz Elżbieta , Kocowicz Andrzej , Bekier Jakub , Dębicka Magdalena , Ćwieląg-Piasecka Irmina 
Published: April 2024

Abstract
Clear-cutting induces biogeochemical, ecological, and hydrological changes in the soil environment, especially in the conditions of climate change effect. This type of management affects soil carbon sequestration. In this paper, we generalize the effect of clear-cutting in mountainous mixed coniferous forests on the direction of organic matter transformation and the properties of humic substances. Soil samples of dystric Cambisols were taken two and ten years after clear-cutting (CC). Soil profiles located at the same elevation under forest cover without any harvesting were used as references. The contents of total organic carbon, total nitrogen, qualitative and quantitative characteristics of humic substances, as well as the mineralogical composition and the clay-associated C fraction, were analysed. Under mountainous conditions, clear-cutting in the mixed coniferous forest enhanced organic matter decomposition and decreased the low-molecular weight humic fraction. It also caused the accumulation of more stable humic acids, particularly in the upper soil horizons, and resulted in accumulation of humic substances with higher contents of C and O and lower H content in the first years after CC. Clear-cutting in the first two years reduced the aliphacity of humic acids in the topsoil. Ten years after harvesting, a significant increase in aliphacity in the Oa horizon confirmed organic matter recovery. Mixed coniferous forests are more resistant to biotic and abiotic disturbances, which is particularly important in the face of violent weather phenomena related to climate change. Thus, forest management plans should consider the conversion of spruce monocultures to mixed coniferous forests.
Vehicle Routing Optimization Algorithms for Pharmaceutical Supply Chain: A Systematic Comparison
Authors: Mamoun Khadija Ait , Hammadi Lamia , Ballouti Abdessamad El , Novaes Antonio G.N. , Cursi Eduardo Souza De 
Published: April 2024

Abstract
Nowadays, supply chain and road networks are full of complexity. Companies can differentiate themselves by offering superior customer service. Therefore, pharmaceutical distributors need to optimize route distribution for efficient and effective delivery to pharmacies, enhancing their competitiveness. In the field of operations research (OR), efficient route optimization is a significant function of the Vehicle Routing Problem (VRP) where the goal is to find the optimal distance travelled. The VRP can be solved using a range of algorithms, comprising exact methods, heuristics and meta-heuristics. This paper gives the basic concepts of some algorithms and these algorithms are compared based on the results. This study also extends its focus to the variation known as the Vehicle Routing Problem with Time Windows (VRPTW), that closely mirrors real-world scenarios, allowing for a more practical assessment of pharmaceutical distribution challenges and optimization solutions.
Kualitas Tidur Berhubungan dengan Fungsi Kognitif pada Lansia di Desa Guwang: Studi Obervasional
Authors: Suputri Ni Wayan Bintang Mida , Wibawa Ari , Putra I Putu Yudi Pramana , Saraswati Putu Ayu Sita 
Published: April 2024

Pendahuluan: Menua merupakan kondisi yang tak terelakkan dalam perjalanan kehidupan manusia. Seseorang yang memasuki usia lansia menjadi rentan terhadap permasalahan kesehatan. Menurut sebuah studi komunitas, prevalensi permasalahan fungsi kognitif pada lansia mencapai 17-34%. Fungsi kognitif merujuk pada proses mental yang terlibat dalam perolehan pengetahuan, manipulasi informasi, dan pemikiran. Berbagai aspek, termasuk kualitas tidur, dapat memengaruhi fungsi kognitif. Kualitas tidur didefinisikan sebagai tingkat kesulitan seseorang dalam memulai dan mempertahankan tidur. Penelitian ini bertujuan untuk mengetahui hubungan antara kualitas tidur dan fungsi kognitif pada lansia di Perkumpulan Lansia Desa Guwang, Sukawati, Gianyar.
Metode: Penelitian ini menggunakan metode observasional analitik dengan pendekatan cross-sectional. Teknik pengambilan sampel yang digunakan adalah consecutive sampling, dengan jumlah sampel sebanyak 66 orang yang memenuhi kriteria inklusi dan eksklusi. Data penelitian terdiri dari skor Pittsburgh Sleep Quality Index (PSQI) dan Mini-Mental State Examination (MMSE).
Hasil: Setelah dilakukan analisis data, diketahui bahwa mayoritas subjek penelitian merupakan lansia dengan kualitas tidur baik, sebanyak 56,1% (n=37), dan fungsi kognitif baik, sebanyak 66,7% (n=44). Uji hipotesis menggunakan spearman’s rho menghasilkan nilai p = 0,001 (p<0,05) dengan koefisien korelasi sebesar 0,406.
Simpulan: Dapat disimpulkan bahwa terdapat hubungan signifikan dan korelasi sedang secara searah antara kualitas tidur dan fungsi kognitif pada lansia di Perkumpulan Lansia Desa Guwang, Sukawati, Gianyar.

Kata Kunci: kualitas tidur, fungsi kognitif, lansia
Studi Perbandingan Otago Exercise dan Star Excursion Balance Exercise dalam Meningkatkan Keseimbangan Dinamis Lansia
Authors: Widyantari Desak Putu Resmi , Prianthara I Made Dhita , Manuaba I A Ratih Wulansari , Suadnyana Ida Ayu Astiti 
Published: April 2024

Pendahuluan: Seiring bertambahnya usia, lansia sering mengalami penurunan fungsi organ, termasuk gangguan keseimbangan. Gangguan keseimbangan dinamis pada lansia dapat berdampak pada kesehatan fisik dan fisiologis, meningkatkan risiko cedera akibat jatuh, bahkan potensial menyebabkan cacat fisik dan kematian. Oleh karena itu, penting untuk melakukan latihan guna mengurangi risiko jatuh. Penelitian ini bertujuan untuk menilai perbedaan efektivitas otago exercise dan star excursion balance exercise dalam meningkatkan keseimbangan dinamis pada lansia di Banjar Sapat, Tegallalang.
Metode: Penelitian ini merupakan penelitian eksperimental dengan desain pre dan post-test two-group. Sampel penelitian terdiri dari 20 orang yang dibagi menjadi dua kelompok. Kelompok pertama menjalani intervensi otago exercise, sedangkan kelompok kedua menjalani intervensi star excursion balance exercise. Pengukuran keseimbangan dinamis dilakukan dengan menggunakan timed up and go test (TUGT).
Hasil: Hasil analisis perbedaan selisih antara kelompok otago exercise dan kelompok star excursion balance exercise menggunakan independent samples t-test menunjukkan nilai p=0,000 (p<0,05), menunjukkan penolakan terhadap hipotesis nol (Ho) dan penerimaan hipotesis alternatif (Ha).
Simpulan: Otago Exercise terbukti lebih efektif dalam meningkatkan keseimbangan dinamis dibandingkan dengan Star Excursion Balance Exercise pada lansia di Banjar Sapat, Tegallalang.

Kata Kunci: keseimbangan dinamis, lansia, otago exercise, star excursion balance exercise
MANAGEMENT OF MAMMARY FIBROADENOMA IN ROTTWEILER DOGS
Authors: Rista Ranggalan Putri  , Anak Agung Gde Jayawardhita  , I Wayan Gorda  
Published: April 2024

Fibroadenoma mammae is a tumor that is formed from a mixture of fibrous and glandular tissue, usually known as a type of benign tumor that grows on mammae. The aim of this study is to report case management fibroadenoma in rottweiler dogs. A Rottweiler dog eight-year-old with a body weight of 24 kg, female sex with a lump in the left (sinistra) second mammary gland. A physical and clinical examination of the dog showed a healthy dog with a good appetite and drink, normal defecation and urination. Routine hematological examination showed an increase in MCV (Mean Corpuscular Volume) and a decrease in MCHC (Mean Corpuscular Hemoglobin Concentration), but not very significant. The results of histopathological examination of tumor tissue samples, the dog was diagnosed with fibroadenoma mammae with a fausta prognosis. Dogs are handled by performing surgery (excision) with the method of mastectomy (regional) to remove the tumor mass and give the antibiotics cefotaxim, cefixime with anti-inflammatory meloxicam, topical drugs such as Enbatic® and hematodin. After surgical removal of the tumor mass and administration of post-operative therapy, the case dog was declared cured with the surgical wound dry and fused on the fourteenth day. Handling fibroadenoma mammae it must be done as quickly as possible to prevent the tumor from metastasizing to other parts of the body.
Implementation of Virtual Reality as an Educational Tool in Higher Education Teaching: A Case Study at the National University of San Marcos, Peru
Authors: Palomino Mauro Betancurt , Carrión Eloy Robles , Mora Víctor Crespo , Zapana Eber Apaza 
Published: April 2024

Objective: Analyze in detail the implementation of virtual reality (VR) as an educational tool in the field of higher education teaching in the specific Peruvian context.

Methods: The study employs a mixed methodology that includes surveys and interviews with teachers and students to assess various aspects, such as the perception of VR usage, its effectiveness in the educational process, and the challenges associated with its implementation. In addition to data collection through surveys and interviews, a detailed analysis of the technological infrastructure available at UNMSM is carried out. This analysis covers aspects such as the availability of equipment and devices compatible with VR, as well as the existence of support resources, such as specialized laboratories or trained technical personnel, to support the effective integration of this technology into the educational environment.
Result: When studying perception, effectiveness, and challenges related to the use of VR in university teaching, this study seeks to provide a comprehensive understanding of how this technology is being adopted and utilized in the Peruvian context. The findings of this research can not only be useful for UNMSM but also serve as a reference for other educational institutions considering the implementation of VR as part of their teaching and learning strategy in higher education.
Hydrothermal Alteration Zones Mapping Using Sentinel 2 MSI and Terra Aster Data in The Uruguay Mine, Minas do Camaquã District
Authors: Novaes Rodrigo Carneiro , Souza Luis Eduardo de , Temporim Filipe Altoé , Abichequer Luciana Arnt 
Published: April 2024

Objective: This work has as main objective to evaluate the usage of data from the Terra ASTER multispectral sensor, as well as data from Sentinel 2 MSI for the identification of hydrothermal alteration zones in the Uruguay Mine. Another objective of this work was to map a not-so-great scale deposit that present a hydrothermal pattern associated in a tropical country.

Method: Were applied principal component analysis and entropy analysis technique to the ASTER surface reflectance data and principal components only to the surface reflectance MSI data. The field spectra provided were obtained with the ASD FieldSpec-3 High-Resolution spectroradiometer. The samples collected contained spectral features characteristic of minerals such as ferric chlorite, hematite, goethite and illite (Phengite).

Result and Conclusion: The ASTER data resulted in a good radial highlighted pattern at the mine location indicating that the processing was able to map the target spectral patterns. The MSI data were processed to map the ferric minerals and presented a pattern highlighting the mine contours and slopes, demonstrating the possible occurrence of minerals containing the aimed spectral features. The entropy usage as an intensity factor applied to intensity-hue-saturation (IHS) fusion on ASTER data improved the reliability of the results, by highlighting the pixels with deepest absorbance features, reducing the uncertainty associated with the process. The results were considered good since both processes showed correspondence in the location of the mine.

Implication of the research: This work contributes for the understanding of spectroscopy analysis of alteration minerals related to copper mineralization, and techniques of remote sensing to map them.

Originality/value: Good results of the application of principal component analysis in the studied area and application of entropy concept in spectral analysis.
The Capacity of Wharton's Jelly to Prolong the Survival of Skin Tissues ex vivo
Authors: Minh Nguyen Quang , Dai Nguyen Dang , Uyen Than Thi Trang 
Published: April 2024

Developing models for preclinical examinations to avoid using animals has been increasing worldwide. Besides creating cell lines or tissues specialized for in vitro testing, biological wastes are also utilized as a potential tissue source for ex vivo examinations. In particular, the human skin from plastic surgery can be an ideal source of skin models to evaluate the effectiveness of some biological products with the advantage of possessing a natural finished skin structure. However, to maintain skin viability under laboratory conditions, it is necessary to establish ex vivo skin tissue nurturing conditions. Therefore, we tested conditions for culturing skin tissue outside the body using the air-liquid interface tissue culture method and Wharton's Jelly (WJ) from the umbilical cords and nutrient medium. The results showed that the skin tissue could maintain and survive in the air-liquid interface tissue culture conditions. Results from observations showed that the size and color of skin tissues were consistent until ten days and 15 days, when skin tissues were maintained in the nutrient media or nutrient media combined with WJ, respectively. Additionally, the histological analysis indicated that cultured skin tissues could maintain their normal structure of three epidermis, dermis, and hypodermis layers; the epidermis started to separate from the dermis after ten days or 15 days, depending on whether skin tissues were maintained in nutrient media only or nutrient media combined with WJ, respectively. Moreover, hair follicles, melanocytes, and keratinocytes were observed at their right location and typical structure. These results indicated that skin could survive in a nutrient medium for ten days, particularly prolonged over 15 days in a combination of nutrient medium and WJ. These results indicated the potential to maintain skin tissue ex vivo and use it for different tests under laboratory conditions.