bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case–control study of the clinical and economic impact of infections caused by Carbapenemase-producing Enterobacterales (CPE)
Authors: López Montesinos Inmaculada , Carot-Coll Aina , Montero Maria Milagro , Sorli Redó Luisa , Siverio-Parès Ana , Esteban-Cucó Sandra , Durán Xavier , Gomez-Zorrilla Silvia , Horcajada Juan Pablo 
Published: May 2024

Abstract
Purpose
The aim was to analyse the clinical and economic impact of carbapenemase-producing Enterobacterales (CPE) infections.

Methods
Case–control study. Adult patients with CPE infections were considered cases, while those with non-CPE infections were controls. Matching criteria were age (± 5 years), sex, source of infection and microorganism (ratio 1:2). Primary outcome was 30-day mortality. Secondary outcomes were 90-day mortality, clinical failure, hospitalisation costs and resource consumption.

Results
246 patients (82 cases and 164 controls) were included. Klebsiella pneumoniae OXA-48 was the most common microorganism causing CPE infections. CPE cases had more prior comorbidities (p = 0.007), septic shock (p = 0.003), and were more likely to receive inappropriate empirical and definitive antibiotic treatment (both p < 0.001). Multivariate analysis identified septic shock and inappropriate empirical treatment as independent predictors for 7-day and end-of-treatment clinical failure, whereas Charlson Index and septic shock were associated with 30- and 90-day mortality. CPE infection was independently associated with early clinical failure (OR 2.18, 95% CI, 1.03–4.59), but not with end-of-treatment clinical failure or 30- or 90-day mortality. In terms of resource consumption, hospitalisation costs for CPE were double those of the non-CPE group. CPE cases had longer hospital stay (p < 0.001), required more long-term care facilities (p < 0.001) and outpatient parenteral antibiotic therapy (p = 0.007).

Conclusions
The CPE group was associated with worse clinical outcomes, but this was mainly due to a higher comorbidity burden, more severe illness, and more frequent inappropriate antibiotic treatment rather than resistance patterns as such. However, the CPE group consumed more healthcare resources and incurred higher costs.
Militant Rule of Law and Not-so-Bad Law
Authors: Sajó András 
Published: May 2024

AbstractThe article provides intellectual arguments and tools from legal dogmatics that can help to counter the rule of law backlash. It argues that resilience can be boosted by a systemic militant rule of law approach. When it comes to restoring the rule of law, legal theory turns to the Radbruch formula (supra-statutory law). This approach remains contested by lawyers who are convinced – following the tradition of positivist legal theory – that invoking this formula is unacceptable because it violates a fundamental requirement of the rule of law, namely that of legality. Irrespective of the value of this concern, Radbruch’s formula is not applicable to the current demise of the rule of law, as the law resulting from cheating and abuse in illiberal regimes does not result in evil law (though it may facilitate such developments). Instead of evil law, we face not-so-bad law. Legal imperfections exist in every legal system, and militant rule of law necessitates the systemic revision of these shortcomings in order to preempt the abuses of an anti-formalistic populist regime. In illiberal regimes, the self-corrective mechanisms of the rule of law are gradually eliminated, but the name of the game remains the rule of law. It means that judges still have (some) power to counter the backlash using extant interpretive techniques (for a while). This article will begin by introducing the concept of not-so-bad (NSB) law as an imperfection of the rule of law. In Part Two, the validity of NSB laws is discussed by relying on the source theory. It argues that even if validity is a matter of conformity to the source, the source can be understood to contain a legal merit component as determined by the rule of law, and falling short on this legal merit component can constitute a ground for declaring the norm’s invalid. Part Three describes the abuses of the rule of law in illiberal democracies and describes how the NSB law of illiberal regimes does not satisfy the validity requirements of legal positivism. Part Four discusses the opportunities open to judges for resisting or undoing NSB law using existing techniques of legal interpretation and without violating rule of law principles.
Bad Religion and Bad Business: The History of the Canadian Witchcraft Provision
Authors: Klassen-Molyneaux Riley 
Published: May 2024

AbstractWitchcraft is a fascinating subject on which many volumes continue to be published. But not in Canada. This article stands in contrast to earlier Canadian pieces on witchcraft whose primary goals were to prove that the witchcraft provision marginalized women and to encourage legislators to repeal it. Parliament finally repealed the Canadian witchcraft prohibition in 2018. The moment is thus ripe to ask how—and why—this legislative oddity migrated from England into Canada. The first section of the paper considers the religious origins of the witchcraft prohibition in England and how it made its way into the Canadian Criminal Code. The second section explores how the prohibition evolved from one against unwanted spiritual practices to one against unwanted economic practices. The last section of the paper considers how witchcraft morphed into a viable Charter defence based on freedom of religion and why the prohibition against it was eventually repealed. In conclusion, the article reflects on the peculiar trajectory of witchcraft in Canada and what it might suggest not only about Canadian criminal law, but also about broader Canadian society.
The Feminine Force in Early Daoist Thought
Authors: Small Sharon Y. 
Published: May 2024

AbstractAccording to theLaozione of the ways to cultivate and grasp Dao is through “remaining female” and “nourishing the mother.” The term mother is used in reference to the beginning of all existence—“the mother of all under heaven,” “the mother of all existences.” The mother is both an active force of generation and the concreteness of the generated beings. In this sense, the feminine attribute of motherhood is a living embodiment of Dao. In the world of myriad phenomena, the mother provides a location of interaction between “absence” and “presence,” betweenwuandyou. In this paper, I suggest an analysis of the metaphor of mother and other “feminine roles” in early Daoist thought through a textual examination of the Laozi. Considering the intellectual background in Warring States period China in which the common understanding of the universe and all phenomena is revealed through the interactions of correlative and complementary forces, the esteem of one over the other—the feminine over the male, the mother over father—is outstanding and deserves serious investigation. The question is what can we learn from the feminine, what can femininity teach us about the world, its generation, and even political practice?
A remark on exact simulation of tempered stable Ornstein–Uhlenbeck processes
Authors: Arai Takuji , Imai Yuto 
Published: May 2024

AbstractQu, Dassios, and Zhao (2021) suggested an exact simulation method for tempered stable Ornstein–Uhlenbeck processes, but their algorithms contain some errors. This short note aims to correct their algorithms and conduct some numerical experiments.
The Translational Turn and the Dual Pressures on Chinese Literary Studies
Authors: Klein Lucas 
Published: May 2024

AbstractWhereas sinology, or the study of Chinese literature in English, has often been identifiable by a Chinese culturism, or belief in Chinese civilization as a coherent whole united by its writing system, this review article looks at five books that could be described as participating in a “translational turn” in Chinese literary studies. Yet even as they make powerful arguments against the fundamental unity and cohesiveness of a diachronic Chinese cultural-political identity in their translingual and translational approaches to scholarship, the books—Carla Nappi’s Translating Early Modern China (2021), Haun Saussy’s The Making of Barbarians (2022), Tze-Yin Teo’s If Babel Had A Form (2022), Yunte Huang’s Chinese Whispers (2022), and Nan Z. Da’s Intransitive Encounter (2018)—risk taking for granted the longevity of China’s participation in globalization and its economic integration with the United States. In light of current changes to the relationship between China, the US, and the world order, this review article reads these books while attempting to think through the gains and pitfalls of the translational turn in Chinese literary studies.
Risk of spread of the Asian citrus psyllid Diaphorina citri Kuwayama (Hemiptera: Liviidae) in Ghana
Authors: Ninsin Kodwo Dadzie , Souza Philipe Guilherme Corcino , Amaro George Correa , Aidoo Owusu Fordjour , Barry Edmond Joseph Djibril Victor , da Silva Ricardo Siqueira , Osei-Owusu Jonathan , Dofuor Aboagye Kwarteng , Ablormeti Fred Kormla , Heve William K. , Edusei George , Agboyi Lakpo Koku , Beseh Patrick , Boafo Hettie Arwoh , Borgemeister Christian , Sétamou Mamoudou 
Published: May 2024

AbstractThe impact of invasive species on biodiversity, food security and economy is increasingly noticeable in various regions of the globe as a consequence of climate change. Yet, there is limited research on how climate change affects the distribution of the invasive Asian citrus psyllid Diaphorina citri Kuwayama (Hemiptera:Liviidae) in Ghana. Using maxnet package to fit the Maxent model in R software, we answered the following questions; (i) what are the main drivers for D. citri distribution, (ii) what are the D. citri-specific habitat requirements and (iii) how well do the risk maps fit with what we know to be correctly based on the available evidence?. We found that temperature seasonality (Bio04), mean temperature of warmest quarter (Bio10), precipitation of driest quarter (Bio17), moderate resolution imaging spectroradiometer land cover and precipitation seasonality (Bio15), were the most important drivers of D. citri distribution. The results follow the known distribution records of the pest with potential expansion of habitat suitability in the future. Because many invasive species, including D. citri, can adapt to the changing climates, our findings can serve as a guide for surveillance, tracking and prevention of D. citri spread in Ghana.
The role of environmental sensitivity in the mental health of Syrian refugee children: a multi-level analysis
Authors: May Andrew K. , Smeeth Demelza , McEwen Fiona , Karam Elie , Rieder Michael J. , Elzagallaai Abdelbaset A. , van Uum Stan , Lionetti Francesca , Pluess Michael 
Published: May 2024

AbstractIndividuals with high environmental sensitivity have nervous systems that are disproportionately receptive to both the protective and imperilling aspects of the environment, suggesting their mental health is strongly context-dependent. However, there have been few consolidated attempts to examine putative markers of sensitivity, across different levels of analysis, within a single cohort of individuals with high-priority mental health needs. Here, we examine psychological (self-report), physiological (hair hormones) and genetic (polygenic scores) markers of sensitivity in a large cohort of 1591 Syrian refugee children across two waves of data. Child-caregiver dyads were recruited from informal tented settlements in Lebanon, and completed a battery of psychological instruments at baseline and follow-up (12 months apart). Univariate and multivariate Bayesian linear mixed models were used to examine a) the interrelationships between markers of sensitivity and b) the ability of sensitivity markers to predict anxiety, depression, post-traumatic stress disorder, and externalising behaviour. Self-reported sensitivity (using the Highly Sensitive Child Scale) significantly predicted a higher burden of all forms of mental illness across both waves, however, there were no significant cross-lagged pathways. Physiological and genetic markers were not stably predictive of self-reported sensitivity, and failed to similarly predict mental health outcomes. The measurement of environmental sensitivity may have significant implications for identifying and treating mental illness, especially amongst vulnerable populations, but clinical utility is currently limited to self-report assessment.
COQ7 defect causes prenatal onset of mitochondrial CoQ10 deficiency with cardiomyopathy and gastrointestinal obstruction
Authors: Pettenuzzo Ilaria , Carli Sara , Sánchez-Cuesta Ana , Isidori Federica , Montanari Francesca , Grippa Mina , Lanzoni Giulia , Ambrosetti Irene , Di Pisa Veronica , Cordelli Duccio Maria , Mondardini Maria Cristina , Pippucci Tommaso , Ragni Luca , Cenacchi Giovanna , Costa Roberta , Lima Mario , Capristo Maria Antonietta , Tropeano Concetta Valentina , Caporali Leonardo , Carelli Valerio , Brunelli Elena , Maffei Monica , Ahmed Sheikhmaye Hodman , Fetta Anna , Brea-Calvo Gloria , Garone Caterina 
Published: May 2024

AbstractCOQ7pathogenetic variants cause primary CoQ10deficiency and a clinical phenotype of encephalopathy, peripheral neuropathy, or multisystemic disorder. Early diagnosis is essential for promptly starting CoQ10supplementation. Here, we report novel compound heterozygous variants in theCOQ7gene responsible for a prenatal onset (20 weeks of gestation) of hypertrophic cardiomyopathy and intestinal dysmotility in a Bangladesh consanguineous family with two affected siblings. The main clinical findings were dysmorphisms, recurrent intestinal occlusions that required ileostomy, left ventricular non-compaction cardiomyopathy, ascending aorta dilation, arterial hypertension, renal dysfunction, diffuse skin desquamation, axial hypotonia, neurodevelopmental delay, and growth retardation. Exome sequencing revealed compound heterozygous rare variants in theCOQ7gene, c.613_617delGCCGGinsCAT (p.Ala205HisfsTer48) and c.403A>G (p.Met135Val). In silico analysis and functional in vitro studies confirmed the pathogenicity of the variants responsible for abolished activities of complexes I + III and II + III in muscle homogenate, severe decrease of CoQ10levels, and reduced basal and maximal respiration in patients’ fibroblasts. The first proband deceased at 14 months of age, whereas supplementation with a high dose of CoQ10(30 mg/kg/day) since the first days of life modified the clinical course in the second child, showing a recovery of milestones acquirement at the last follow-up (18 months of age). Our study expands the clinical spectrum of primary CoQ10deficiency due toCOQ7gene defects and highlights the essential role of multidisciplinary and combined approaches for a timely diagnosis.
ETV4 is a mechanical transducer linking cell crowding dynamics to lineage specification
Authors: Yang Seungbok , Golkaram Mahdi , Oh Seyoun , Oh Yujeong , Cho Yoonjae , Yoe Jeehyun , Ju Sungeun , Lalli Matthew A. , Park Seung-Yeol , Lee Yoontae , Jang Jiwon 
Published: May 2024

AbstractDynamic changes in mechanical microenvironments, such as cell crowding, regulate lineage fates as well as cell proliferation. Although regulatory mechanisms for contact inhibition of proliferation have been extensively studied, it remains unclear how cell crowding induces lineage specification. Here we found that a well-known oncogene, ETS variant transcription factor 4 (ETV4), serves as a molecular transducer that links mechanical microenvironments and gene expression. In a growing epithelium of human embryonic stem cells, cell crowding dynamics is translated into ETV4 expression, serving as a pre-pattern for future lineage fates. A switch-like ETV4 inactivation by cell crowding derepresses the potential for neuroectoderm differentiation in human embryonic stem cell epithelia. Mechanistically, cell crowding inactivates the integrin–actomyosin pathway and blocks the endocytosis of fibroblast growth factor receptors (FGFRs). The disrupted FGFR endocytosis induces a marked decrease in ETV4 protein stability through ERK inactivation. Mathematical modelling demonstrates that the dynamics of cell density in a growing human embryonic stem cell epithelium precisely determines the spatiotemporal ETV4 expression pattern and, consequently, the timing and geometry of lineage development. Our findings suggest that cell crowding dynamics in a stem cell epithelium drives spatiotemporal lineage specification using ETV4 as a key mechanical transducer.
Research on the method of determining the block size for an open-pit mine integrating mining parameters and shovel-truck’s operation efficiency
Authors: Guo Weiqiang , Liu Guangwei , Li Jiaming , Chai Senlin , Guo Shupeng 
Published: May 2024

AbstractThe production plan of an open-pit mine depends on the block model, so it's crucial to determine the appropriate method and size for partitioning it. This study proposes a new method based on a closed shell three-dimensional geological model for determining block model size in open-pit mines. Instead of using regular block models, the shell model is directly cut, and the discrete geological body is referred to as the "mining model." Mining parameters and the shovel-truck's performance are integrated into the method. Bench height determines the Z-axis size, bench slope angle determines the inclination angle, and shovel width determines the X-axis size of the block model. The operation efficiency of the shovel-truck considers the probability distribution of simultaneous operations, allowing the determination of the Y-axis size of block models for different types of shovels. The developed "Mining Model" module in the software "Life Cycle Mining System" is used for practical implementation. By comparing the results with traditional block models, the superiority of the proposed method is demonstrated. This study provides a more accurate model for optimizing the production plan of open-pit mines throughout their life cycle.
Elucidating immunological characteristics of the adenoma-carcinoma sequence in colorectal cancer patients in South Korea using a bioinformatics approach
Authors: Song Jaeseung , Kim Daeun , Jung Junghyun , Choi Eunyoung , Lee Yubin , Jeong Yeonbin , Lee Byungjo , Lee Sora , Shim Yujeong , Won Youngtae , Cho Hyeki , Jang Dong Kee , Kang Hyoun Woo , Joo Jong Wha J. , Jang Wonhee 
Published: May 2024

AbstractColorectal cancer (CRC) is one of the top five most common and life-threatening malignancies worldwide. Most CRC develops from advanced colorectal adenoma (ACA), a precancerous stage, through the adenoma-carcinoma sequence. However, its underlying mechanisms, including how the tumor microenvironment changes, remain elusive. Therefore, we conducted an integrative analysis comparing RNA-seq data collected from 40 ACA patients who visited Dongguk University Ilsan Hospital with normal adjacent colons and tumor samples from 18 CRC patients collected from a public database. Differential expression analysis identified 21 and 79 sequentially up- or down-regulated genes across the continuum, respectively. The functional centrality of the continuum genes was assessed through network analysis, identifying 11 up- and 13 down-regulated hub-genes. Subsequently, we validated the prognostic effects of hub-genes using the Kaplan–Meier survival analysis. To estimate the immunological transition of the adenoma-carcinoma sequence, single-cell deconvolution and immune repertoire analyses were conducted. Significant composition changes for innate immunity cells and decreased plasma B-cells with immunoglobulin diversity were observed, along with distinctive immunoglobulin recombination patterns. Taken together, we believe our findings suggest underlying transcriptional and immunological changes during the adenoma-carcinoma sequence, contributing to the further development of pre-diagnostic markers for CRC.
Enhanced microstructure and mechanical properties of ZrN-reinforced AlSi10Mg aluminum matrix composite
Authors: Suvorova Veronika , Volodko Sergey , Suvorov Dmitrii , Chernyshikhin Stanislav , Nepapushev Andrey , Korol Artem , Volkova Lidiya , Sokolov Pavel , Khort Alexander , Moskovskikh Dmitry 
Published: May 2024

AbstractAluminum matrix composites (AMCs), incorporating Zirconium Nitride (ZrN) as reinforcing additives, demonstrate immense promise for applications in aerospace, automotive, and power generation due to their unique combination of low density, superior mechanical properties, and excellent thermal/electrical conductivity. This study explores the influence of ZrN reinforcement on the microstructure and mechanical properties of AlSi10Mg metal-matrix composites. Utilizing high-energy ball milling (HEBM) and spark-plasma sintering (SPS), ZrN/AlSi10Mg composites were synthesized, achieving nearly full density with uniform ZrN distribution, while phase and chemical transformations were not observed in the bulk composites. The addition of ZrN resulted in a notable increase in hardness of 237% (182 ± 8 HV2), elastic modulus of 56% (114 ± 3 GPa), compressive and tensile strength of 183% (565 ± 15 GPa), and 125% (387 ± 9 GPa), respectively, for composites containing 30% ZrN, compared to the non-reinforced alloy. Experimentally determined coefficients of thermal expansion (CTEs) for composites with 10%, 20%, and 30% ZrN content were 19.8 × 10−6 °C−1, 19.1 × 10−6 °C−1, and 18 × 10−6 °C−1, respectively, which well relates to Schapery’s model. These findings contribute to understanding the synthesis, mechanical behavior, and thermal properties of ZrN/AlSi10Mg composites, demonstrating their potential for diverse engineering applications.
Unlocking the potential of blockchain technology in enhancing the fisheries supply chain: an exploration of critical adoption barriers in China
Authors: Nisar Ubair , Zhang Zhixin , Wood Bronwyn P. , Ahmad Shadab , Ellahi Ehsan , Ul Haq Syed Ijaz , Alnafissa Mohamad , Fathi Abd-Allah Elsayed 
Published: May 2024

AbstractThe application of blockchain technology holds significant potential for improving efficiency, resilience, and transparency within the Fisheries Supply Chain (FSC). This study addresses the critical barriers hindering the adoption of blockchain technology (BT) in the Chinese FSC, recognizing the unique challenges posed by its intricacies. Through a comprehensive literature review, fourteen Critical Barrier Factors (CBFs) were identified, and a grey Delphi method was employed to distill this set. Five pivotal CBFs emerged, including "Regulatory Compliance," "Cost of Implementation," and "Complex Supply Chain Network". A subsequent grey Decision-Making Trial and Evaluation Laboratory (DEMATEL) analysis revealed the causal relationships among these factors, categorizing them into effect and cause groups. "Regulatory Compliance," "Cost of Implementation," and "Complex Supply Chain Network" were identified as primary influencing factors demanding attention for effective BT integration in the FSC. The findings serve as a valuable resource for FSC stakeholders, assisting in prioritizing efforts to address these barriers. The discerned causal relationships provide guidance for managers in optimizing resource allocation. Ultimately, this research advocates for the adoption of blockchain technology in the fisheries supply chain to enhance overall performance and operational efficiency.