bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluoride bioavailability in saliva during acute psychological stress
Authors: Naumova Ella , Sandulescu Tudor , Benson Sven , Engler Harald , Schedlowski Manfred , Zimmer Stefan , Gaengler Peter , Thie Michael , Arnold Wolfgang 
Published: May 2012

Abstract
The aim of this study was to investigate the influence of acute stress on salivary fluoride bioavailability. Acute psychological stress was induced using a standardized model of public speaking. The saliva of male subjects was collected before and after the public speaking task and immediately, 10, 30, and 120 minutes after tooth brushing according to the Bass method with a dentifrice containing amine fluoride (AmF) or oral hygiene tablets containing sodium fluoride (NaF). Subjective psychological responses to public speaking were evaluated using the State-Trait Anxiety Inventory (STAI). Saliva cortisol levels were analyzed as an objective stress marker. The saliva secretion rate was measured both before and after public speaking. Saliva fluoride content was measured. Group comparisons were calculated using a univariate analysis of variance (ANOVA). In all analyses, the alpha-level was set at 0.05. Public speaking significantly increased state anxiety (p<0.001) and salivary cortisol concentrations (p<0.001). Acute stress did not influence salivary secretion rates. In the AmF group, stressed individuals exhibited statistically significant (p=0.044) lower fluoride concentration in saliva compared with the nonstressed subjects Acute psychological stress reactions do not cause hyposalivation but decrease fluoride bioavailability after using a dentifrice containing AmF. Fluoride bioavailability during acute stress is dependent on fluoride formulation.
Novel ammonium phosphinates containing peptide moiety: Synthesis, structure, and in vitro antimicrobial activity
Authors: Gholivand Khodayar , Dorosti Niloufar 
Published: May 2012

AbstractFive new ammonium phosphinates with formula [XC6H4NHC(O)NHP(O)YO]−[H2Y]+ (Y = N(CH3)(CH2C6H5), X = H (IV), CH3 (V), NO2 (VI); Y = NH(CH2C6H5), X = H (VII), NO2 (VIII)) were synthesised by the reaction of N-arylureidophoshoryl dichlorides with N-methylbenzylamine or benzylamine in the presence of an excess amount of the corresponding amine. All new compounds were characterised by NMR and IR spectral data and elemental analysis. Their antimicrobial activity was tested against some Gram-positive and Gram-negative bacteria and fungi. Compounds IV and VIII exhibited moderate activity in vitro against Bacillus subtilis. In addition, compound VIII moderately inhibited Pseudomonas aeruginosa. The crystal structure of benzylmethylammonium(3-phenylureido)(benzylmethylamino)phosphinate (IV) was also determined. This compound crystallises in the orthorhombic system.
Effect of animal age and gender on fatty acid and elemental composition in Austrian beef applicable for authentication purposes
Authors: Bednárová Adriána , Mocák Ján , Gössler Walter , Velik Margit , Kaufmann Josef , Staruch Ladislav 
Published: May 2012

AbstractThe main aim of the present study was to find differences in the content of fatty acids and variations in elemental composition in beef samples of longissimus dorsi muscle related to cattle age and gender. A further goal was to describe interrelations among the selected variables (descriptors) characterising the samples. For this purpose, an extensive data table was compiled, which contains chemical descriptors specifying forty-six beef samples originating from four well-known Austrian grassland-based beef labels. The following descriptors were investigated: (a) concentrations of 33 fatty acids, (b) concentrations of 19 elements, (c) contents of dry-mass, protein, intramuscular fat, and ash, (d) total content of saturated fatty acids (SFA), mono-unsaturated fatty acids (MUFA), and poly-unsaturated fatty acids (PUFA), (e) total contents of omega-3 (n-3) and omega-6 (n-6) PUFA and their ratio. The correlation analysis provided a number of statistically significant correlations among the descriptors, which were concordant with the results of the principal component analysis and cluster analysis. Furthermore, the effect of age and gender of cattle (both acting as target factors) on the fatty acid content and elemental composition of beef was examined by analysis of variance (ANOVA) and appropriate non-parametric tests. Several important interrelations among the beef characteristics investigated were also discovered. Finally, the most relevant beef descriptors were utilised in linear discrimination analysis (LDA) for predicting the slaughter age of the cattle for beef authentication.
Effect of Ag-doping of nanosized FeMgO system on its structural, surface, spectral, and catalytic properties
Authors: El-Molla Sahar , Ali Laila , Amin Nabil , Ebrahim Anwer , Mahmoud Hala 
Published: May 2012

AbstractThe effects of Ag-doping on the physico-chemical, spectral, surface, and catalytic properties of the FeMgO system with various Fe2O3 loadings were investigated. The dopant (Ag) molar ratio varied between 0.01 % and 0.05 %. The techniques employed for characterisation of catalysts were TG/DTG, XRD, ESR, N2 adsorption at −196°C, and catalytic decomposition of H2O2 at 25–35°C. The results obtained revealed that the investigated catalysts consisted of nanosized MgO as the major phase, apart from the MgFe2O4 and/or Fe3O4 phases. ESR result of the FeMgO system revealed the presence of paramagnetic species as a result of Ag-doping. The textural properties including SBET, porosity and St were modified by Ag-doping. The doping process with Ag-species improved the catalytic activity of the FeMgO system. Increasing the calcination temperature from 400°C to 800°C increased the catalytic activity (k*30 °C) of 0.05 AgFeMgO in H2O2 decomposition by 21.2 times.
Metabolomic approach to Alzheimer’s disease diagnosis based on mass spectrometry
Authors: González-Domínguez Raúl , García-Barrera Tamara , Gómez-Ariza José-Luis 
Published: May 2012

AbstractAlzheimer’s disease is the most common neurodegenerative disease, but there is still no cure and early diagnosis remains very difficult. For this reason, the discovery of new biomarkers is of great importance. The application of metabolomics is emerging in this field, based on the use of mass spectrometry as a technique of analysis. In this work, blood serum samples (from Alzheimer’s disease patients and healthy controls) were analysed by mass spectrometry in order to search for potential metabolomic biomarkers. The application of multivariate statistical tools (PLS-DA) enabled us to discriminate between groups. In addition, some phosphatidylcholine compounds were identified as markers of the disease.
Ethylcellulose, polycaprolactone, and eudragit matrices for controlled release of piroxicam from tablets and microspheres
Authors: Diaf Kheira , Bahri Zineb , Chafi Nafa , Belarbi Lahcen , Mesli Abderrezzak 
Published: May 2012

AbstractThe present paper provides details of the preparation of polymeric tablets and microspheres based on piroxicam as a therapeutic active agent and the drug release study from these formulations. Tablets composed of ethylcellulose, Eudragit® or mixtures of Eudragit® and synthesised poly(oxepan-2-one) were prepared and tested. The effect of the matrix on the drug release at 37°C was studied. The drug-loaded microparticles were prepared using solvent evaporation microencapsulation. These systems were characterised by SEM and FTIR spectroscopy and the size and size distribution were also determined. The results demonstrated that the drug release could be modified by means of these formulations. Finally, piroxicam dissolution rate constants were calculated from Higuchi’s release model.
Adsorption kinetics and equilibrium of phenol drifts on three zeolites
Authors: Koubaissy Bachar , Toufaily Joumana , El-Murr Maya , Jean Daou T. , Hafez Hala , Joly Guy , Magnoux Patrick , Hamieh Tayssir 
Published: May 2012

Abstract
In this study, the sorption of phenol drifts was studied by performing batch kinetic sorption experiments. The equilibrium kinetic data was analyzed using the pseudo-second-order kinetic model. Fowler-Guggenheim model gives a perfect fitting with the isotherm data. The influence of porous structure of a zeolite particle on phenol adsorption from aqueous solutions is analyzed and discussed. The adsorption for phenol drifts on zeolite was proved to be an exothermic process. Thus the solubility of the phenolic compound and the pH of the solution play also an important role in adsorption phenomena.
The relative affinity of the phenolic compound toward the zeolite was related to the electron donor-acceptor complexes that were formed between the basic sites on the zeolite (oxygen) and hydrogens (acidic site) of the phenols. Finally zeolite seems to be an efficient adsorbent; it can be easily regenerated by methanol leaching.
Les smart shoppers : profils et reactions de ces acheteurs « malins » face à des réductions de prix immédiates
Authors: Labbé-Pinlon Blandine , Lombart Cindy , Louis Didier 
Published: May 2012

Résumé L’objectif de cette recherche est de dresser un profil actuel des smart shoppers pour des produits d’achats courants et de différencier les réactions en magasins (perceptions et comportements) de ces acheteurs « malins » face à des réductions de prix immédiates, de celles des autres acheteurs, notamment des acheteurs utilitaires. L’expérimentation menée dans un magasin laboratoire confirme que les smart shoppers prêtent plus attention aux promotions-prix et achètent plus de produits en promotion que les autres acheteurs. Ils seraient toutefois plus réactifs au signal promotionnel qu’au bénéfice économique réel dans la mesure où ils ont les mêmes réactions face à des réductions de prix faibles versus fortes.
Au confluent du droit et de la gestion : la légistique pour évaluer l'utilisation de la dimension entrepreneuriale de la loi sur l'Innovation
Authors: Philippart Pascal 
Published: May 2012

Résumé Partant du constat que peu d’entreprises innovantes étaient créées par ou avec des chercheurs publics pour valoriser leurs travaux, le législateur français a voté en 1999 une loi, dite loi sur l’Innovation. Plus de dix ans après, ce dispositif à l’intention entrepreneuriale clairement affichée est-il une réussite ? Son évaluation, inscrite dans le cadre théorique de la légistique, articule les objectifs affichés, leur traduction normative et leur utilisation concrète. Les résultats auxquels nous parvenons sont clairs : la loi est un échec qu’il faut relativiser... Plusieurs explications sont proposées et discutées.
Place de la culture d'entreprise dans un processus d'innovation chez les PME de haute technologie : une étude de cas par comparaison inter sites
Authors: Rave-Habhab Saida 
Published: May 2012

Résumé Les entreprises, à l’instar des autres collectivités humaines, ont une culture d’entreprise. Celle-ci est le fruit d’une dynamique complexe où, jouent des facteurs aussi divers que la nature de l’activité, l’histoire de l’organisation et la mémorisation de ses réussites et de ses échecs, la personnalité du dirigeant, etc. Or, l’innovation, par son importance stratégique comme par sa force suggestive et symbolique, constitue un « pivot » crucial de la culture d’entreprise, autour duquel se structurent et se positionnent les représentations collectives constituant la culture de l’entreprise. La reconnaissance de la culture d’entreprise constitue une avancée significative pour l’analyse des processus d’innovation. Elle introduit toutefois un certain nombre d’interrogations, la littérature en la matière restant encore largement exploratoire. Parmi ces questionnements, la nature de relation (interaction) entre l’innovation et la culture d’entreprise ainsi que l’étude des mécanismes de l’émergence d’une culture d’innovation apparaissent encore peu explorées. Nous nous sommes donc intéressés à ces deux volets afin de rendre compte de la complexité de la relation entre innovation et culture d’entreprise. Plus précisément, notre article se propose de répondre aux questions suivantes : « Comment les innovations technologiques et la culture d’entreprise évoluent-elles et s’influencent-elles dans un environnement technologique ? » ; « Quels sont les mécanismes de création d’une culture d’innovation dans leur dimension technologique et organisationnelle ? ». Pour répondre à ces questions, nous avons eu recours à une analyse qualitative reposant sur une étude de cas par inter sites, centrée sur les PME innovantes de haute technologie. Les principaux résultats de notre recherche ont souligné l’existence d’une relation d’influence mutuelle entre innovation et culture d’entreprise. De plus, l’étude des mécanismes de l’émergence de culture d’innovation donne une compréhension plus fine de cette relation. Elle permet enfin de spécifier le rapport entre innovation et culture et souligne l’existence d’une nouvelle forme de rapport à l’innovation et, plus largement aux choix technologiques. Cette forme souligne l’importance (la place) de la culture d’entreprise dans un processus d’innovation.
The Cytoskeletal Adaptor Protein IQGAP1 Regulates TCR-Mediated Signaling and Filamentous Actin Dynamics
Authors: Gorman Jacquelyn A. , Babich Alexander , Dick Christopher J. , Schoon Renee A. , Koenig Alexander , Gomez Timothy S. , Burkhardt Janis K. , Billadeau Daniel D. 
Published: May 2012

AbstractThe Ras GTPase-activating-like protein IQGAP1 is a multimodular scaffold that controls signaling and cytoskeletal regulation in fibroblasts and epithelial cells. However, the functional role of IQGAP1 in T cell development, activation, and cytoskeletal regulation has not been investigated. In this study, we show that IQGAP1 is dispensable for thymocyte development as well as microtubule organizing center polarization and cytolytic function in CD8+ T cells. However, IQGAP1-deficient CD8+ T cells as well as Jurkat T cells suppressed for IQGAP1 were hyperresponsive, displaying increased IL-2 and IFN-γ production, heightened LCK activation, and augmented global phosphorylation kinetics after TCR ligation. In addition, IQGAP1-deficient T cells exhibited increased TCR-mediated F-actin assembly and amplified F-actin velocities during spreading. Moreover, we found that discrete regions of IQGAP1 regulated cellular activation and F-actin accumulation. Taken together, our data suggest that IQGAP1 acts as a dual negative regulator in T cells, limiting both TCR-mediated activation kinetics and F-actin dynamics via distinct mechanisms.
Amino-Terminal Extended Peptide Single-Chain Trimers Are Potent Synthetic Agonists for Memory Human CD8+ T Cells
Authors: Carreno Beatriz M. , Becker-Hapak Michelle , Chan Megan , Lie Wen-Rong , Wang Xiaoli , Hansen Ted H. , Linette Gerald P. 
Published: May 2012

Abstract
Upon Ag exposure, most memory T cells undergo restimulation-induced cell death. In this article, we describe a novel synthetic agonist, an N-terminal extended decamer peptide expressed as a single-chain trimer, the amino-terminal extended peptide MHC class I single-chain trimer (AT-SCT), which preferentially promotes the growth of memory human CD8+ T cells with minimal restimulation-induced cell death. Using CMV pp65 and melanoma gp100 Ags, we observe the in vitro numerical expansion of a clonally diverse polyfunctional population of Ag-specific CD8+ T cells from healthy individuals and vaccinated melanoma patients, respectively. Memory CD8+ T cells stimulated with AT-SCT presented on MHC class I/II-null cells show reduced cytokine production, slower kinetics of TCR downregulation, and decreased cell death compared with native nonamer MHC class I single-chain trimer (SCT)-activated T cells. However, both ERK phosphorylation and cell cycle kinetics are identical in AT-SCT– and SCT-activated T cells. Probing of SCT and AT-SCT peptide–MHC complexes using fluorochrome-conjugated TCR multimers suggests that nonamer- and decamer-linked peptides may be anchored differently to the HLA-A2 peptide-binding groove. Our findings demonstrate that modified peptide–MHC structures, such as AT-SCT, can be engineered as T cell agonists to promote the growth and expansion of memory human CD8+ T cells.
Identification of TLT2 as an Engulfment Receptor for Apoptotic Cells
Authors: de Freitas Andressa , Banerjee Sami , Xie Na , Cui Huachun , Davis Kasey I. , Friggeri Arnaud , Fu Mingui , Abraham Edward , Liu Gang 
Published: May 2012

Abstract
Clearance of apoptotic cells (efferocytosis) is critical to the homeostasis of the immune system by restraining inflammation and autoimmune response to intracellular Ags released from dying cells. TLRs-mediated innate immunity plays an important role in pathogen clearance and in regulation of the adaptive immune response. However, the regulation of efferocytosis by activation of TLRs has not been well characterized. In this study, we found that activation of TLR3 or TLR9, but not of TLR2, enhances engulfment of apoptotic cells by macrophages. We found that the activation of TLR3 upregulates the expression of triggering receptor expressed on myeloid cells (TREM)-like protein 2 (TLT2), a member of the TREM receptor family, on the surface of macrophages. Blocking TLT2 on the macrophage surface by either specific anti-TLT2 Ab or soluble TLT2 extracellular domain attenuated the enhanced ability of macrophages with TLR3 activation to engulf apoptotic cells. To the contrary, overexpression of TLT2 increased the phagocytosis of apoptotic cells. We found that TLT2 specifically binds to phosphatidylserine, a major “eat me” signal that is exposed on the surface of apoptotic cells. Furthermore, we found that TLT2 mediates phagocytosis of apoptotic cells in vivo. Thus, our studies identified TLT2 as an engulfment receptor for apoptotic cells. Our data also suggest a novel mechanism by which TREM receptors regulate inflammation and autoimmune response.
Natural and laser-induced cavitation in corn stems: On the mechanisms of acoustic emissions
Authors: Fernández E. , Fernández R. J. , Bilmes Gabriel Mario 
Published: May 2012

Water in plant xylem is often superheated, and therefore in a meta-stable state. Under certain conditions, it may suddenly turn from the liquid to the vapor state. This cavitation process produces acoustic emissions. We report the measurement of ultrasonic acoustic emissions (UAE) produced by natural and induced cavitation in corn stems. We induced cavitation and UAE in vivo, in well controlled and reproducible experiments, by irradiating the bare stem of the plants with a continuous-wave laser beam. By tracing the source of UAE, we were able to detect absorption and frequency filtering of the UAE propagating through the stem. This technique allows the unique possibility of studying localized embolism of plant conduits, and thus to test hypotheses on the hydraulic architecture of plants. Based on our results, we postulate that the source of UAE is a transient "cavity oscillation"' triggered by the disruptive effect of cavitation inception.Received: 14 March 2011, Accepted: 23 April 2012; Edited by: V. Lakshminarayanan; Reviewed by: C. Negreira, Laboratorio de Acústica Ultrasonora, Universidad de la República, Uruguay; DOI: http://dx.doi.org/10.4279/PIP.040003Cite as: E. Fernández, R. J. Fernández, G. M. Bilmes, Papers in Physics 4, 040003 (2012)
Cross-Country Growth Empirics and Model Uncertainty: An Overview
Authors: Ulaşan Bülent 
Published: May 2012

Abstract
The aim of this paper is to provide an overview of empirical cross-country growth literature. The paper begins with describing the basic framework used in recent empirical crosscountry growth research. Even though this literature was mainly inspired by endogenous growth theories, the neoclassical growth model is still the workhorse for cross-country growth empirics. The second part of the paper emphasises model uncertainty, which is indeed immense but generally neglected in the empirical cross-country growth literature. The most outstanding feature of the literature is that a large number of factors have been suggested as fundamental growth determinants. Together with the small sample property, this leads to an important problem: model uncertainty. The questions which factors are more fundamental in explaining growth dynamics and hence growth differences are still the subject of academic research. Recent attempts based on general-to-specific modeling or model averaging are promising but have their own limits. Finally, the paper highlights the implications of model uncertainty for policy evaluation.
Metal Painting by Plasma Jet
Authors: Lockwood Estrin Francis , Hagger Oliver S.J. , Sener M. Emre , Caruana Daren J. 
Published: June 2024

AbstractConducting metal interconnections are essential to link electronic components or multiple circuits for electronic device fabrication. Scalable, rapid, and sustainable methods for printing adherent metal interconnections on dielectric materials are lacking, which stifles the development of new electronic consumer devices. Here a breakthrough single‐step and rapid process to deposit highly conducting metal tracks is introduced, using an atmospheric pressure plasma jet. The deposition process used a rudimentary aqueous solution of metal salts as ink, that was introduced as a mist into a helium plasma gas. The metal salt was reduced and deposited with spatiotemporal control using a plasma jet generated at radio frequency with 15 W power at room temperature and pressure. The conductive metal layers were highly adhesive on glass, ceramics, polymeric materials, even biological surfaces such as plant leaves and animal skin, depostedwith little damage to the substrate. The conductivity of deposited tracks on glass shows 50.8 ± 8.6% and 5.2 ± 1.6% of bulk silver and copper metal conductivity respectively.
Regioselective Annulation of 3(5)‐Aminopyrazole with Aryl Ketones or Aryl Alkynes Using N,N‐Dimethylethanolamine as a Single/Triple Carbon Synthon
Authors: Zhang Xinyu , Chen Jing , Chen Rener , Wang Lei , Ma Yongmin 
Published: June 2024

AbstractAn efficient and regioselective cyclization for construction of pyrazolo[3,4‐b]pyridines and methylene‐bridged bis(pyrazolo[1,5‐a]pyrimidines) has been established. It involves a [3+2+1] annulation of 3(5)‐aminopyrazole, N,N‐dimethylethanolamine (DMEA), with 1,2‐insertion of aryl methyl ketones or 2,1‐insertion of aryl alkynes. DMEA is oxidized through C(sp3)‐H activation to provide a single or triple carbon source.