bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased Copper in Individuals with Autism Normalizes Post Zinc Therapy More Efficiently in Individuals with Concurrent GI Disease
Authors: Russo Anthony J. 
Published: September 2011

Aim To assess plasma zinc and copper concentration in individuals with autism. Subjects and Methods Plasma from 79 autistic individuals, and 18 age and gender similar neurotypical controls, were tested for plasma zinc and copper using inductively-coupled plasma-mass spectrometry. Results Autistic individuals had significantly elevated plasma levels of copper and Cu/Zn and lower, but not significantly lower, plasma Zn compared to neurotypical controls. Zn levels increased significantly in autistic individuals with and without GI disease after zinc therapy. Cu decreased significantly after zinc therapy in the GI disease group but not in the autistic group without GI disease. Autistic children significantly improved with respect to hyperactivity and stimming after zinc therapy in autistic children with GI disease. Autistic children without GI disease did not improve in these symptoms after the same therapy. Discussion These results suggest an association between zinc and copper plasma levels and autism, and they suggest that zinc therapy may be most effective at lowering copper levels in autistic children with GI disease.
Evaluation of Cell‐Material Interactions on Newly Designed, Printable Polymers for Tissue Engineering Applications
Authors: Novosel Esther C. , Meyer Wolfdietrich , Klechowitz Nadine , Krüger Hartmut , Wegener Michael , Walles Heike , Tovar Günter E. M. , Hirth Thomas , Kluger Petra J. 
Published: September 2011

AbstractThe generation of advanced scaffolds for tissue engineering is increasingly implemented by rapid prototyping techniques and therefore designed materials. Two novel polymeric networks based on newly synthesized carboxyfunctionalized polyacrylates were created to fit the requirements of 3D printing processes regarding viscosity and their surface tension. The polyacrylates presented carboxylic groups either without any spacer, or, in the case of mono‐(2‐acryloxyethyl)‐succinate, with a substantial spacing from the polymer backbone. The material properties were characterized with rheometry, FTIR, XPS, and contact angle measurements. Polymer surfaces were prepared and seeded with primary human dermal microvascular endothelial cells (HDMEC). Cell–material interaction with the different polymer surfaces were investigated by light microscopy, water soluble tetrazolium‐1 (WST‐1) viability assay, fluorescein diacetate/propidium iodide (FDA/PI) staining, and acetylated low‐density lipoprotein (acLDL) assay. Thus, the cell confluence, viability, and functionality of the HDMEC were evaluated. The non‐spaced methacrylic acid derivative was proved in cell culture regarding its biocompatibility. Along with its appropriate physical properties, the novel network‐generating polymeric blends constitute promising candidates for future scaffold design in tissue engineering.
Near‐Surface Microstructural Reorganization of UHMWPE under Cyclic Load – A Pilot Study
Authors: Keller Thomas F. , Engelhardt Hannes , Adam Peter , Galetz Mathias C. , Glatzel Uwe , Jandt Klaus D. 
Published: September 2011

AbstractWe report a depth‐resolved analysis of the microstructure of a bulge‐like failure in a medical grade ultra high molecular weight polyethylene (UHMWPE) implant material induced by a cyclic load. The depth‐dependent arrangement of the crystalline lamellae was analyzed by cross‐sectional transmission electron microscopy (TEM). The failure emerges at the top wear surface as an amorphous bulge with a maximum thickness of approximately 300 µm. A sharp interface below the bulge consists of an approximately 0.1 µm thick boundary layer with stacked lamellae with an outstanding degree of orientation perpendicular to the wear surface. The boundary layer is separated from the intact, unmodified base material with random lamellar orientation by an approximately 5 µm thick transition zone with a lamellar alignment perpendicular to the wear surface, which decreases toward the center of the UHMWPE test specimen. We further observed an overall decrease of lamellar thickness toward the wear surface within the influence zone. This indicates the strength and heterogeneity of the local dynamic stress field during cyclic wear and the ease for lamellar rearrangements presumably facilitated by a locally elevated temperature. We propose the bulge to originate from either wear material dragged along the wear surface or from a retransfer from the articulating counter surface, and discuss implications on the degree and relevance of adhesive wear. This study stresses the importance of the UHMWPE transfer material under such dynamic load conditions. Our approach seems suitable for investigating the mechanical aspect of failure mechanisms at the UHMWPE polymer biointerface under cyclic load.
Synthesis of Arylated Quinolines by Chemo‐ and Site‐selective Suzuki–Miyaura Reactions of 5,7‐Dibromo‐8‐(trifluoromethanesulfonyloxy)quinoline
Authors: Eleya Nadi , Mahal Ahmed , Hein Martin , Villinger Alexander , Langer Peter 
Published: September 2011

AbstractArylated quinolines were prepared by Suzuki–Miyaura reactions of 5,7‐dibromo‐8‐(trifluoromethanesulfonyloxy)quinoline. The reactions proceed with excellent site‐selectivity. The first, second and third attack occur at positions 5, 7 and 8, respectively.
Human neoteny revisited: The case of synaptic plasticity
Authors: Bufill Enric , Agustí Jordi , Blesa Rafael 
Published: September 2011

AbstractThe process of learning requires morphological changes in the neuronal connections and the formation of new synapses. Due to the importance of memory and learning in our species, it has been suggested that the synaptic plasticity in a number of association areas is higher in the human brain than in other primates. Cortical neurons in mammals are characterized by higher metabolism, activity, and synaptic plasticity during development and the juvenile stage than in the adult. In Homo sapiens, brain development is retarded compared with other primates, especially in some association areas. These areas are characterized by the presence of neurons, which remain structurally immature throughout their lifespans and show an increase in the expression of the genes, which deal with metabolism and the activity and synaptic plasticity in adulthood. The retention of juvenile features in some adult neurons in our species has occurred in areas, which are related to episodic memory, planning, and social navigation. The increase of the aerobic metabolism in these neurons may lead, however, to higher levels of oxidative stress, therefore, favoring the development of neurodegenerative diseases which are exclusive, or almost exclusive, to humans, such as Alzheimer's disease. Am. J. Hum. Biol. 2011. © 2011 Wiley‐Liss, Inc.
CO Oxidation as a Prototypical Reaction for Heterogeneous Processes
Authors: Freund Hans‐Joachim , Meijer Gerard , Scheffler Matthias , Schlögl Robert , Wolf Martin 
Published: September 2011

AbstractCO oxidation, although seemingly a simple chemical reaction, provides us with a panacea that reveals the richness and beauty of heterogeneous catalysis. The Fritz Haber Institute is a place where a multidisciplinary approach to study the course of such a heterogeneous reaction can be generated in house. Research at the institute is primarily curiosity driven, which is reflected in the five sections comprising this Review. We use an approach based on microscopic concepts to study the interaction of simple molecules with well‐defined materials, such as clusters in the gas phase or solid surfaces. This approach often asks for the development of new methods, tools, and materials to prove them, and it is exactly this aspect, both, with respect to experiment and theory, that is a trade mark of our institute.
Synthesis and Biological Evaluation of Novel Homocamptothecins Conjugating with Dihydropyrimidine Derivatives as Potent Topoisomerase I Inhibitors
Authors: Zhu Lingjian , Cheng Pengfei , Lei Ning , Yao Jianzhong , Sheng Chunquan , Zhuang Chunlin , Guo Wei , Liu Wenfeng , Zhang Yongqiang , Dong Guoqiang , Wang Shengzhang , Miao Zhenyuan , Zhang Wannian 
Published: September 2011

AbstractHomocamptothecin (hCPT) is a camptothecin (CPT) homologue with the insertion of a methylene (CH2) spacer between the alcohol moiety and carbonyl group of the classical six‐membered α‐hydroxylactone ring. This modification provides higher lactone stability and did not impair its activity against topoisomerase I (Topo I), but rather appears to improve it compared to CPT. In an attempt to improve the antitumor activity of homocamptothecins, a series of novel hCPT derivatives conjugating with dihydropyrimidine (DHPM) derivatives was designed and synthesized based on a synthetic route which couples 7‐formylhomocamptothecin with different dihydropyrimidine derivates. Most of the synthesized compounds exhibited good antiproliferative activity on tumor cell lines A549, MDA‐MB‐435 and HCT116. Furthermore, this class of compounds showed superior Topo I inhibition activity comparable to or higher than CPT.
SVEEVA Descriptor Application to Peptide QSAR
Authors: Tong Jianbo , Che Ting , Liu Shuling , Li Yunfei , Wang Ping , Xu Xiameng , Chen Yang 
Published: September 2011

AbstractA new descriptor, SVEEVA (principal component scores vector of electronic eigenvalue descriptors), was derived from principal component analysis (PCA) of a matrix of 220 electronic eigenvalue descriptors of coded amino acids. SVEEVA scales were then applied in three panels of peptide quantitative structure–activity relationship (QSAR) that were modeled by partial least squares regression (PLS). The obtained models with the correlation coefficient ($R_{{\rm cum}}^{2} $), cross‐validation correlation coefficient ($Q_{{\rm LOO}}^{2} $) were 0.894 and 0.839 for 58 angiotensin‐converting enzyme inhibitors, 0.995 and 0.949 for 12 antimicrobial polypeptides, and 0.995 and 0.976 for 20 thromboplastin inhibitors. Satisfactory results showed that information related to biological activity can be systemically expressed by SVEEVA scales, which may be a useful structural expression methodology for study on peptide QSAR.
Synthesis, Telomerase Evaluation and Anti‐Proliferative Studies on Various Series of Diaminoanthraquinone‐Linked Aminoacyl Residue Derivatives
Authors: Huang Fong‐Chun , Huang Kuo‐Feng , Chen Ruey‐Hui , Wu Jia‐Er , Chen Tsung‐Chih , Chen Chun‐Liang , Lee Chia‐Chung , Chen Jin‐Yang , Lin Jing‐Jer , Huang Hsu‐Shan 
Published: September 2011

AbstractFour series of compounds containing an anthraquinone‐linked moiety and symmetrical or asymmetrical aminoacyl residues in side chains at positions 1,4‐, 1,5‐, 2,6‐, and 2,7‐ were synthesized and evaluated for their inhibitory effects toward telomerase and hTERT expression. Of these, only compound B11 showed selective inhibition of telomerase activity. Although it is not as competent as several of the anthraquinones we identified previously, nevertheless, the result is consistent with that the general structure moiety at the 1,5‐position of diaminoanthraquinone‐linked compound is important for the telomerase inhibitory activity. Interestingly, compounds A6, A8, C8, and D8 exhibited selective repressing activities toward hTERT expression and showed less effect toward proliferation of the treated cancer cells. Although it is not apparent which structure moiety is responsible for the telomerase repression effects of these compounds, they could be further developed as potential anti‐tumor agents.
Constitutive and dark‐induced expression of Solanum tuberosum phosphoenolpyruvate carboxylase enhances stomatal opening and photosynthetic performance of Arabidopsis thaliana
Authors: Kebeish Rashad , Niessen Markus , Oksaksin Mehtap , Blume Christian , Peterhaensel Christoph 
Published: September 2011

AbstractThe effect of constitutive and dark‐induced expression of Solanum tuberosum phosphoenolpyruvate carboxylase (PEPC) on the opening state of stomata and photosynthetic performance in Arabidopsis thaliana plants was studied. Transcript accumulation analyses of the A. thaliana dark‐induced (Din10 and Din6) and the Pisum sativum asparagine synthetase 2 promoters (Asn2) in transiently transformed tobacco leaves showed that Din10 promoter induced more DsRed accumulation in the dark compared to the other din genes. Overexpression of PEPC under the control of the constitutive enhanced CaMV 35S (p35SS) and dark‐induced Din10 promoter in stably transformed A. thaliana plants increased the number of opened stomata in dark adapted leaves. Gas exchange measurements using A. thaliana plants transgenic for p35SS‐PEPC and Din10‐PEPC revealed a marked increase in stomatal conductance, transpiration, and dark respiration rates measured in the dark compared to wild‐type plants. Moreover, measurement of CO2 assimilation rates at different external CO2 concentrations (Ca) and different light intensities shows an increase in the CO2 assimilation rates in transgenic Arabidopsis lines compared to wild‐type plants. This is considered as first step towards transferring the aspects of Crassulacean acid metabolism‐like photosynthetic mechanism into C3 plants. Biotechnol. Bioeng. 2012; 109:536–544. © 2011 Wiley Periodicals, Inc.
Statistical Analysis of Past Catalytic Data on Oxidative Methane Coupling for New Insights into the Composition of High‐Performance Catalysts
Authors: Zavyalova Ulyana , Holena Martin , Schlögl Robert , Baerns Manfred 
Published: September 2011

AbstractA database consisting of 1870 data sets on catalyst compositions and their performances in the oxidative coupling of methane was compiled. For this goal, about 1000 full‐text references from the last 30 years have been analyzed and about 420 of them, which contained all the necessary information, were selected for the data extraction. The accumulated data were subject to statistical analysis: analysis of variance, correlation analysis, and decision tree. On the basis of the results, 18 catalytic key elements were selected from originally 68 elements. All oxides of the selected elements, which positively affect the selectivity to C2 products, show strong basicity. Analysis of binary and ternary interactions between the selected key elements shows that high‐performance catalysts are mainly based on Mg and La oxides. Alkali (Cs, Na) and alkaline‐earth (Sr, Ba) metals used as dopants increase the selectivity of the host oxides, whereas dopants such as Mn, W, and the Cl anion have positive effects on the catalyst activity. The maximal C2 selectivities for the proposed catalyst compositions range from 72 to 82 %, and the respective C2 yields range from 16 to 26 %.
Route to a Family of Robust, Non‐interpenetrated Metal–Organic Frameworks with pto‐like Topology
Authors: Klein Nicole , Senkovska Irena , Baburin Igor A. , Grünker Ronny , Stoeck Ulrich , Schlichtenmayer Maurice , Streppel Barbara , Mueller Uwe , Leoni Stefano , Hirscher Michael , Kaskel Stefan 
Published: September 2011

AbstractA combination of topological rules and quantum chemical calculations has facilitated the development of a rational metal–organic framework (MOF) synthetic strategy using the tritopic benzene‐1,3,5‐tribenzoate (btb) linker and a neutral cross‐linker 4,4′‐bipyridine (bipy). A series of new compounds, namely [M2(bipy)]3(btb)4 (DUT‐23(M), M=Zn, Co, Cu, Ni), [Cu2(bisqui)0.5]3(btb)4 (DUT‐24, bisqui=diethyl (R,S)‐4,4′‐biquinoline‐3,3′‐dicarboxylate), [Cu2(py)1.5(H2O)0.5]3(btb)4 (DUT‐33, py=pyridine), and [Cu2(H2O)2]3(btb)4 (DUT‐34), with high specific surface areas and pore volumes (up to 2.03 m3 g−1 for DUT‐23(Co)) were synthesized. For DUT‐23(Co), excess storage capacities were determined for methane (268 mg g−1 at 100 bar and 298 K), hydrogen (74 mg g−1 at 40 bar and 77 K), and n‐butane (99 mg g−1at 293 K). DUT‐34 is a non‐cross‐linked version of DUT‐23 (non‐interpenetrated pendant to MOF‐14) that possesses open metal sites and can therefore be used as a catalyst. The accessibility of the pores in DUT‐34 to potential substrate molecules was proven by liquid phase adsorption. By exchanging the N,N donor 4,4′‐bipyridine with a substituted racemic biquinoline, DUT‐24 was obtained. This opens a route to the synthesis of a chiral compound, which could be interesting for enantioselective separation.
ChemInform Abstract: The Remarkable Improvement of a Ce—Ti Based Catalyst for NOx Abatement, Prepared by a Homogeneous Precipitation Method.
Authors: Shan Wenpo , Liu Fudong , He Hong , Shi Xiaoyan , Zhang Changbin 
Published: September 2011

AbstractCe—Ti mixed oxide catalysts are prepared by precipitation from aqueous solutions of Ce(NO3)3 and Ti(SO4)2 with molar Ce/Ti ratios of 0.1, 0.2, 0.5, and 1.0 using excessive aqueous solution of urea (90 °C, 8 h), followed by calcination of the precipitate at 400, 500, or 600 °C for 5 h in air.
ChemInform Abstract: Rapid (≈10 min) Synthesis of Single‐Crystalline, Nanorice TiO2 Mesoparticles with a High Photovoltaic Efficiency of above 8%.
Authors: Parmar K. P. S. , Ramasamy Easwaramoorthi , Lee Jinwoo , Lee Jae Sung 
Published: September 2011

AbstractAnatase TiO2 mesopowders of single‐crystalline rice‐like nanoparticles (6—15 nm wide, 30—100 nm long) are hydrothermally synthesized from a mixture of Ti(OPr)4, acac, NH3, and H2O (autoclave, microwave irradiation, pH 11.7, 180 °C, 10 min).
ChemInform Abstract: Assembly of a Family of Mixed Metal {Mo : V} Polyoxometalates Templated by TeO32‐: {Mo12V12Te3}, {Mo12V12Te2} and {Mo17V8Te}.
Authors: Corella‐Ochoa M. Nieves , Miras Haralampos N. , Kidd Alastair , Long De‐Liang , Cronin Leroy 
Published: September 2011

AbstractThe crystal structures of (IV), (VII), and (VIII) are determined by single crystal XRD.
ChemInform Abstract: An Efficient and Heterogeneous Recyclable Palladium Catalyst for Chemoselective Conjugate Reduction of α,β‐Unsaturated Carbonyls in Aqueous Medium.
Authors: Bagal Dattatraya B. , Qureshi Ziyauddin S. , Dhake Kishor P. , Khan Shoeb R. , Bhanage Bhalchandra M. 
Published: September 2011

AbstractA complete green and convenient strategy for the chemoselective transfer hydrogenation of various α,β‐unsaturated carbonyl compounds using HCOONa as hydrogen source and a polymer‐supported Pd‐NHC catalyst system is given.
ChemInform Abstract: Preparation of Secondary and Tertiary Amines from Nitroarenes and Alcohols.
Authors: Lee Chun‐Chin , Liu Shiuh‐Tzung 
Published: September 2011

AbstractVarious secondary amines (III) are obtained from the reaction of nitroarenes (I) with primary alcohols (II) in the presence of Ru(II) complexes having phosphine‐amine ligands as the catalyst.
ChemInform Abstract: New Ligands and Structural Insights into the Catalytic Asymmetric Addition of Organozinc Reagents to Ketones.
Authors: Huelgas Gabriela , LaRochelle Lynne K. , Rivas Lucrecia , Luchinina Yekaterina , Toscano Ruben A. , Carroll Patrick J. , Walsh Patrick J. , Anaya de Parrodi Cecilia 
Published: September 2011

AbstractThe scope of the novel chiral ligand ADA is evaluated in the catalytic asymmetric addition of ZnEt2 to ketones.
ChemInform Abstract: Chiral Primary Amine Catalyzed Asymmetric Direct Cross‐Aldol Reaction of Acetaldehyde.
Authors: Hu Shenshen , Zhang Long , Li Jiuyuan , Luo Sanzhong , Cheng Jin‐Pei 
Published: September 2011

AbstractAqueous acetaldehyde solution and paraldehyde can be conveniently applied in this reaction.
ChemInform Abstract: Asymmetric Aza‐Henry Reaction with α‐Substituted Nitroacetates Catalyzed by a Bifunctional Thiourea‐Guanidine Catalyst.
Authors: Han Bo , Huang Wei , Xu Zhen Rui , Dong Xiao Ping 
Published: September 2011

AbstractThe process renders possible a facile access to β‐nitroamine derivatives bearing adjacent quaternary and tertiary chiral centers.
ChemInform Abstract: Stereoselective Synthesis of Ambiphilic Alkenes via Regioselective Methylation of α‐Trifluoromethanesulfonyl Carbonyl Compounds with Trimethylsilyldiazomethane.
Authors: Kong Han Il , Crichton Jennifer E. , Manthorpe Jeffrey M. 
Published: September 2011

AbstractTriflyl‐substituted enol ethers or ketene aminals are synthesized through a selective O‐methylation of the corresponding carbonyl compounds with azo compound (VI).
ChemInform Abstract: Suzuki—Miyaura Cross‐Coupling Reactions in Flow: Multistep Synthesis Enabled by a Microfluidic Extraction.
Authors: Noel Timothy , Kuhn Simon , Musacchio Andrew J. , Jensen Klavs F. , Buchwald Stephen L. 
Published: September 2011

AbstractA continuous‐flow microfluidic system is developed for the transformation of phenols into their corresponding aryl triflates followed by Suzuki—Miyaura cross‐coupling reaction to afford biaryls directly.
ChemInform Abstract: Reductive Coupling of Aromatic N,N‐Acetals Using Zinc and Chlorotrimethylsilane.
Authors: Hatano Bunpei , Tachikawa Tomoharu , Mori Tetsunori , Nagahashi Keita , Kijima Tatsuro 
Published: September 2011

AbstractAromatic N,N‐acetals and N,O‐acetal (X), activated by TmsCl, are coupled in the presence of zinc to give mixtures of dl‐ and meso‐diamines.
ChemInform Abstract: Highly Selective Synthesis of β‐Amino Carbonyl Compounds over ZSM‐5‐SO3H under Solvent‐Free Conditions.
Authors: Massah Ahmad Reza , Kalbasi Roozbeh , Samah Neda 
Published: September 2011

AbstractA new mild method for the Mannich reaction including an easy work‐up and the use of a recoverable and reusable catalyst is presented.
ChemInform Abstract: Lead(IV) Acetate Oxidative Ring‐Opening of 2,3‐Epoxy Primary Alcohols: A New Entry to Optically Active α‐Hydroxy Carbonyl Compounds.
Authors: Alvarez‐Manzaneda Enrique , Chahboun Rachid , Alvarez Esteban , Alvarez‐Manzaneda Ramon , Munoz Pedro E. , Jimenez Fermin , Bouanou Hanane 
Published: September 2011

AbstractNucleophilic ring‐opening of hydroxymethyl‐substituted substrates with Pb(OAc)4 results in formation of α‐acetoxy aldehydes or α‐acetoxy ketones.
ChemInform Abstract: AgBF4/[Bmim]BF4‐Catalyzed [3 + 2] Cycloaddition of Cyclic Diazodicarbonyl Compounds: Efficient Synthesis of 2,3‐Dihydrofurans and Conversion to 3‐Acylfurans.
Authors: Xia Likai , Lee Yong Rok , Kim Sung Hong , Lyoo Won Seok 
Published: September 2011

AbstractA novel, mild, and efficient method for the synthesis of the title compounds (III) and (V) is presented.
ChemInform Abstract: Synthesis of Novel Triazol Compounds Containing Isatin as Potential Antibacterial and Antifungal Agents by Microwave and Conventional Methods.
Authors: Oezil Musa , Mentese Emre , Yilmaz Fatih , Islamoglu Fatih , Kahveci Bahittin 
Published: September 2011

AbstractA variety of novel Schiff bases (III) is synthesized by reaction of isatin derivatives (I) with aminotriazolones (II) under both conventional thermal and microwave irradiation conditions.
ChemInform Abstract: Oxidation of Urazoles to Their Corresponding Triazolinediones Using Benzyltriphenylphosphonium Nitrate.
Authors: Samimi Heshmat Allah , Parvanak Kaveh 
Published: September 2011

AbstractBenzyltriphenylphosphonium nitrate is a mild, stable and easily available reagent for the oxidation of different types of urazoles.
ChemInform Abstract: CuFe2O4 Nanoparticles: A Magnetically Recoverable and Reusable Catalyst for the Synthesis of 5‐Substituted 1H‐Tetrazoles.
Authors: Sreedhar B. , Kumar A. Suresh , Yada Divya 
Published: September 2011

AbstractThe catalyst can be reused five times without significant loss of activity.
ChemInform Abstract: Reaction of 1,3‐Bis(trimethylsilyloxy)‐1,3‐butadienes with 2,4,6‐Tris(trifluoromethyl)‐1,3,5‐triazine: Planning and Serendipity.
Authors: Iaroshenko Viktor O. , Bunescu Alina , Spannenberg Anke , Langer Peter 
Published: September 2011

AbstractA new type of formal [3 + 3] cyclization reaction of triazine (I) with silyloxybutadienes (II) is discovered.
ChemInform Abstract: Synthesis of Antagonists of Muscarinic (M3) Receptors.
Authors: Broadley Kenneth J. , Davies Robin H. , Escargueil Christine , Lee Alan T. L. , Penson Peter , Thomas Eric J. 
Published: September 2011

AbstractA series of α‐hydroxyamides of type (VII) and (VIII) are prepared and evaluated as antagonists of the M3 muscarinic receptor in guinea pig ileum.