bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do Adult Disease Severity Subclassifications Predict Use of Cyclophosphamide in Children with ANCA-associated Vasculitis? An Analysis of ARChiVe Study Treatment Decisions
Authors: MORISHITA KIMBERLY , GUZMAN JAIME , CHIRA PETER , MUSCAL EYAL , ZEFT ANDREW , KLEIN-GITELMAN MARISA , URIBE AMERICA G. , ABRAMSON LESLIE , BENSELER SUSANNE M. , EBERHARD ANNE , EDE KALEO , HASHKES PHILIP J. , HERSH AIMEE O. , HIGGINS GLORIA , IMUNDO LISA F. , JUNG LAWRENCE , KIM SUSAN , KINGSBURY DANIEL J. , LAWSON ERICA F. , LEE TZIELAN , LI SUZANNE C. , LOVELL DANIEL J. , MASON THOMAS , McCURDY DEBORAH , O’NEIL KATHLEEN M. , PUNARO MARILYNN , RAMSEY SUZANNE E. , REIFF ANDREAS , ROSENKRANZ MARGALIT , SCHIKLER KENNETH N. , SCUCCIMARRI ROSIE , SINGER NORA G. , STEVENS ANNE M. , van MATER HEATHER , WAHEZI DAWN M. , WHITE ANDREW J. , CABRAL DAVID A. 
Published: August 2012

Objective.To determine whether adult disease severity subclassification systems for antineutrophil cytoplasmic antibody-associated vasculitis (AAV) are concordant with the decision to treat pediatric patients with cyclophosphamide (CYC).Methods.We applied the European Vasculitis Study (EUVAS) and Wegener’s Granulomatosis Etanercept Trial (WGET) disease severity subclassification systems to pediatric patients with AAV in A Registry for Childhood Vasculitis (ARChiVe). Modifications were made to the EUVAS and WGET systems to enable their application to this cohort of children. Treatment was categorized into 2 groups, “cyclophosphamide” and “no cyclophosphamide.” Pearson’s chi-square and Kendall’s rank correlation coefficient statistical analyses were used to determine the relationship between disease severity subgroup and treatment at the time of diagnosis.Results.In total, 125 children with AAV were studied. Severity subgroup was associated with treatment group in both the EUVAS (chi-square 45.14, p < 0.001, Kendall’s tau-b 0.601, p < 0.001) and WGET (chi-square 59.33, p < 0.001, Kendall’s tau-b 0.689, p < 0.001) systems; however, 7 children classified by both systems as having less severe disease received CYC, and 6 children classified as having severe disease by both systems did not receive CYC.Conclusion.In this pediatric AAV cohort, the EUVAS and WGET adult severity subclassification systems had strong correlation with physician choice of treatment. However, a proportion of patients received treatment that was not concordant with their assigned severity subclass.
Drilling the Femoral Tunnel During ACL Reconstruction: Transtibial Versus Anteromedial Portal Techniques
Authors: Tudisco Cosimo , Bisicchia Salvatore 
Published: August 2012

Incorrect bone tunnel position, particularly on the femoral side, is a frequent cause of failed anterior cruciate ligament reconstruction. Several studies have reported that drilling the femoral tunnel through the anteromedial portal allows a more anatomical placement on the lateral femoral condyle and higher knee stability than does transtibial reconstruction.
In the current study, the femoral tunnel was drilled with transtibial (n=6) and anteromedial (n=6) portal techniques in 12 cadaveric knees. With appropriate landmarks inserted into bone tunnels, the direction and length of the tunnels were determined on anteroposterior and lateral radiographs. Knee stability was evaluated with a KT1000 arthrometer (MEDmetric Corporation, San Diego, California) and pivot shift test, comparing the pre- and postoperative values of both techniques. Finally, all knees were dissected to enhance vision of the insertion of the reconstructed ligament. The anteromedial portal technique led to better placement of the femoral tunnel in the coronal and sagittal planes, with higher knee stability according to the pivot shift test but not the KT1000 arthrometer.
Anatomical and clinical results reported in the literature on transtibial and anteromedial portal techniques are controversial, but most of studies report better results with the anteromedial portal technique, especially regarding rotational stability. The current cadaveric study showed that the anteromedial portal technique provided better tunnel placement on the lateral femoral condyle in the coronal and sagittal planes, with an improvement in the rotational stability of the knee.
Effect of Donor Age on Patellar Tendon Allograft ACL Reconstruction
Authors: Hampton Daniel M. , Lamb Joshua , Klimkiewicz John J. 
Published: August 2012

Anterior cruciate ligament reconstruction with patellar tendon allograft tissue is a common orthopedic procedure. It is unknown what effect, if any, the donor age has on clinical outcomes. Biomechanical studies have shown the strength of cadaveric patellar tendon to be independent of age, but no clinical studies have evaluated patient outcomes related to this variable. The purpose of this study was to evaluate the effect of allograft donor age on clinical outcomes of patients undergoing allograft anterior cruciate ligament reconstruction with patellar tendon allograft.
Case logs were reviewed to identify primary anterior cruciate ligament reconstruction with allograft patellar tendon by a single surgeon using a standard endoscopic transtibial technique with interference screw fixation. Revision and multiligamentous surgeries were excluded. Seventy-seven patients who met these criteria were identified. Allografts were fresh-frozen, aseptically harvested patellar tendons from a single tissue bank. The donor age was obtained. Clinical outcomes were obtained by contacting patients by telephone and retrospective chart review. Pre- and postoperative Lysholm and Tegner knee scores were used for comparison.

Data from 75 patients with an average follow-up of 24 months were obtained. Average donor age was 44 years (range, 14–65 years), and average patient age was 37 years (range, 18–60 years). Statistical analysis of pre- and postoperative Lysholm scores demonstrated statistically significant improvement (
P
⩽.001). Using donor age as a continuous variable, no effect was found on postoperative improvement in Lysholm score or Tegner score (
P
=.6).
Knee Pain in Patients With Cancer After Chemotherapy, Radiotherapy, and Bone Marrow Transplantation
Authors: Chen Eileen , Sethi Sajiv , Lee Adrienne , Sethi Anil , Vaidya Rahul 
Published: August 2012

The causes of knee pain in patients with cancer with are different from those without cancer, and the purpose of this study was to evaluate these differences. Thirty-six patients with cancer who had knee pain who had undergone 1 or more modalities of treatment, including chemotherapy, radiotherapy, and bone marrow transplant, for a primary diagnosis of cancer were compared with a cohort of 40 patients without cancer who had knee pain. All patients were evaluated clinically and underwent radiographic examination, and some underwent computed tomography or magnetic resonance imaging examination. Among patients with a primary diagnosis of cancer, the most common diagnosis was lymphoma (n=10), and the most common causes of knee pain were avascular necrosis of bone, osteoarthritis, insufficiency fractures, and septic arthritis. In 5 patients, the classical signs of a septic knee were not present. Other causes of knee pain included meniscus tear and anterior cruciate ligament rupture with instability. The most common diagnosis in patients without cancer was osteoarthritis of the knee. No patient without cancer was diagnosed with avascular necrosis, metastatic lesion, or insufficiency fracture. Two patients without cancer were diagnosed with septic arthritis of the knee.
This study showed that the causes of knee pain in patients with cancer are different from those without cancer. Septic arthritis may present without the classical clinical signs in patients with cancer, and a high index of suspicion should be maintained for it.
Catastrophic Fracture of a Stable Metal Acetabular Component
Authors: Papaliodis Dean N. , Uhl Richard L. , Fuchs Marc D. 
Published: August 2012

Various modes of failure of primary and revision total hip arthroplasty have been well documented in the literature over the past 30 years. Concerns over polyethylene wear, osteolysis, and hypersensitivity reactions leading to component loosening and early revision have been evaluated and reported in the literature. Routine follow-up is important to monitor for postoperative issues that might lead to the subsequent need for revision.
This article describes a case of a 64-year-old man who initially presented 11 years prior with an intertrochanteric fracture, which failed secondary to varus alignment and femoral head osteonecrosis. The fixation was converted to a total hip replacement using the S-ROM system (DePuy, Warsaw, Indiana). Subsequently, the patient was lost to follow-up after primary total hip arthroplasty and presented with a catastrophic fracture of the metal acetabular cup system. The failure was suggested by clinical presentation and confirmed by imaging studies showing a fractured acetabular shell with femoral head prosthesis resting in the superolateral ileum. The contributing factors that resulted in mechanical failure were polyethylene wear and component fracture. The acetabular component was revised with an in-growth cementless trabecular metal multihole cup (Zimmer, Warsaw, Indiana) with bone grafting of acetabular defects.
Routine assessments help educate patients and allow careful monitoring by physicians while establishing a radiographic timeline for the identification, progression, or lack of postoperative complications.
Parallel Plating for a Sternomanubrial Dislocation
Authors: Gaines Robert J. , Wilson Addison , Antevil Jared , Demaio Marlene 
Published: August 2012

Sternomanubrial dislocations are rare injuries. Although few cases of this injury have been reported in the literature, the etiology has varied widely: trampoline injury, seizures, falls from height, sporting injuries, gradual deformities from spine fractures, and motor vehicle collisions. This injury has been classified into 2 types: in type I, the sternal body is displaced posteriorly to the manubrium, and in the more common type II, the sternal body is displaced anteriorly. The sternomanubrial joint is an amphiarthroidal joint that bears hyaline cartilage on both surfaces connected by a fibrocartilage meniscus. It serves a protective role to vital thoracic structures and is an anterior stabilizing strut to the thorax, assisting the thoracic spine in upright stability. It is important to not ignore type I dislocations because posterior sternum displacement is a harbinger of injury to the pulmonary tree, heart, and esophagus. Chronic instability at this joint can lead to dyspnea and dysphasia due to sternum displacement. In the right scenario, type II injuries are occasionally treated conservatively with palliative treatment until the sternum heals with malformation.
This article describes the case of a 20-year-old man who was treated surgically for symptomatic type II sternomanubrial dislocation with dual anterior locked plating. Locked plating gives the benefit of unicortical fixation, with the screws and plate acting as a unit to resist motion. Screw pullout and failure is less common, and the construct is more resistant for this application. The patient returned to full participation in activities of daily living and military duty 4 months postoperatively.
Single-level Calcified Cervical Disk Herniation in a 13-year-old Girl
Authors: Li Min , Rong Weiping , Pan Xianming , Yu Lin 
Published: August 2012

This article describes a case of a 13-year-old girl with single-level calcified cervical disk herniation. The patient was treated conservatively for a symptomatic intervertebral calcification that caused neurological compression, and the data were reviewed retrospectively. Previous reports have shown that the natural history of the disease is self-limiting with a benign course and an excellent prognosis. However, on rare occasions when the calcified nucleus pulposus herniates into the spinal canal and compresses the spinal cord or its roots, neurological abnormalities can occur, such as radiculopathy and myelopathy. This also raises the question of whether operative therapy will eventually be necessary.
In the current case, conservative treatment was applied. Plain radiographs are usually sufficient to determine the presence and extent of a calcified cervical disk, and computed tomography or magnetic resonance imaging can detect an associated disk herniation. Conservative treatment with antalgics, muscle relaxants, neurotrophic drugs, and a cervical collar were applied. The patient was completely free of symptoms 3 weeks after the initial treatment. Magnetic resonance imaging indicated complete vertebral canal clearance at final follow-up.
Cervical intervertebral disk calcification and herniation is a rare disorder in children with an obscure etiology but a good prognosis. Conservative therapy produces satisfactory results, even if clinical symptoms due to nerve root or spinal cord compression are present. Surgical treatments are only suitable in rare cases with severe progressive radicular pain or neurological deficit.
Comparison of Keratometric Data Obtained by Automated Keratometer, Dicon CT 200, Allegro Topolyzer, and Pentacam
Authors: Gonen Tansu , Cosar C. Banu , Sener Bozkurt , Keskinbora Kadircan H. 
Published: August 2012

PURPOSE:
To compare the keratometric values measured by the automated keratometer, two Placido-based computerized topography systems (Dicon CT 200 [Vismed Inc] and Allegro Topolyzer [WaveLight Inc]), and Scheimpflug analysis (Pentacam [Oculus Optikgeräte GmbH]).

METHODS:
The keratometric data of 200 eyes from 200 patients evaluated for refractive surgery were reviewed retrospectively. Mean simulated keratometry (Sim K) and mean corneal astigmatism measured by the four devices were compared using repeated measures analysis of variance with Bonferroni correction. The analysis of agreement between two measurements was assessed using the method of Bland and Altman.

RESULTS:

Mean Sim K as measured by the automated keratometer, Dicon CT 200, Allegro Topolyzer, and Pentacam was 43.39±1.50 diopters (D), 43.55±1.50 D, 43.45±1.50 D, and 43.43±1.45 D, respectively. The Dicon CT 200 measured the mean Sim K to be steeper and the automated keratometer measured the mean Sim K to be flatter than the other devices. Significant differences in corneal astigmatism were noted among the four devices except Dicon CT 200 versus Allegro Topolyzer and Allegro Topolyzer versus Pentacam comparisons (
P
<.013). For mean Sim K, the 95% limits of agreement between the Pentacam and other three devices were significantly wider than the other comparisons. In Bland-Altman plots comparing the Pentacam to the other devices, extreme outliers were present in 11 (5.5%) eyes.

CONCLUSIONS:
Because of the wide distribution range and presence of extreme outliers, Pentacam data should be used cautiously in IOL power calculation and astigmatic keratotomy procedures.
Morphometric Analysis of Epiretinal Membranes Using SD-OCT
Authors: Gao Yuduan , Smiddy William E. 
Published: August 2012

BACKGROUND AND OBJECTIVE:To determine whether the volumes of macular layers before and after epiretinal membrane (ERM) peeling as measured by spectral-domain optical coherence tomography (SD-OCT) correlated with best-corrected visual acuity (BCVA) or ERM location.PATIENTS AND METHODS:Thirty-six eyes with idiopathic ERM and 12 control eyes were imaged preoperatively and postoperatively using SD-OCT. The inner, middle, and outer retinal layers were measured in the temporal and nasal half of the central 1,500 μm of the macula for each of the SD-OCT five raster scans and used to estimate the volumes for each group.RESULTS:The inner layer volumes were larger in cases compared with control eyes. The nasal inner and temporal inner layer volumes decreased after ERM removal in the nasal dominant, macular dominant, and temporal dominant groups. The inner layer volume decreased more temporally than nasally in the macular dominant and temporal dominant groups but not in the nasal dominant group. The volume decreased more in the temporal middle than the nasal middle layer for the temporal dominant group. The BCVA improvement correlated with nasal inner layer volume decrease and nasal outer and temporal outer layer volume increase.CONCLUSION:The volume of the inner perifoveal retinal sections decreases after ERM peeling, possibly representing resolution of edema or reorganization of the nerve fiber layer on release of mechanical traction. Visual improvement correlated with volume increase of the outer retinal layers and may represent photoreceptor cell recovery after ERM peeling.
The timing and significance of gully incision on the eastern flank of the Faroe–Shetland Channel and its impact on seafloor infrastructure
Authors: Stewart Heather A. , Long David 
Published: August 2012

AbstractThe Faroe–Shetland Channel is an area of active offshore development and the safety of the sea‐floor infrastructure is paramount. This study has concentrated on a system of down‐slope linear gullies and associated debris fans located to the west of Shetland in water depths of between 465m and 995m. Three‐dimensional seismic, two‐dimensional seismic and multibeam echosounder data have been combined to map the sea‐bed morphology and shallow sub‐surface geology associated with these features. The localised debris fans and gullies are interpreted as the products of high energy mass‐flow fed by an ancient ice‐stream constrained to this part of the West Shetland Shelf. During decay of this ice‐stream, melt‐water plumes of sediment released from the retreating ice front have formed a thin (<5m) laminated sediment drape overlying the debris fans observed from seismic data. At present locally strong oceanic currents rework and redistribute sea‐bed sediments into sediment drifts called contourites that cover much of the sea bed of the Faroe–Shetland Channel. These along‐slope deposits have been shown to infill erosional features located further northeast along the continental slope, however, these deposits thin to the southwest reflecting the increasing strength of present day oceanic currents impeding deposition. This study shows that slope angles within the down‐slope gullies exceed 20° and cut down into earlier contouritic sediments. The high slope angles recorded on the multibeam echosounder data combined with video data confirm the presence of near‐vertical sediment cliffs within the gullies. This is of significance to industry as there are currently producing hydrocarbon fields and continued exploration in and around these sea‐bed features.
Multidisciplinary investigation of a shallow near‐shore landslide, Finneidfjord, Norway
Authors: Vardy Mark E. , L’Heureux Jean‐Sebastien , Vanneste Maarten , Longva Oddvar , Steiner Alois , Forsberg Carl Fredrik , Haflidason Haflidi , Brendryen Jo 
Published: August 2012

ABSTRACTThe 1996 landslide near Finneidfjord, Norway, involved the displacement of c. 1 x 106 m3 of sediment. Failure initiated offshore and developed in a retrogressive manner, 100–150 m inland and removing a 250 m long section of the main north‐south highway. The landslide caused the loss of four human lives and may have been triggered by human activity (e.g., blasting for road works and/or placement of fill along the shore). Acquisition of an extensive and multidisciplinary data set, including high‐resolution swath bathymetry, 2D/3D seismic data, multiple short (up to 6 m) and two long (12 m and 14 m, respectively) sediment cores and in situ Free‐Fall Piezocone Penetrometer (FF‐CPTU) profiles complemented with geotechnical laboratory data, has provided a detailed analysis of both the landslide morphology and stratigraphic controls. Using regional 2D parametric sub‐bottom profiler (TOPAS) profiles and a targeted decimetre‐resolution 3D Chirp seismic volume (950 m x 140 m), we focus on post‐failure material transport/deposition, correlating the failure plane against one of several regionally extensive packets of high‐amplitude, composite reflections. In seismic reflection data, the slide plane lies within a distinct, thin (< 0.5 m) stratigraphic bed of lower acoustic impedance than the background sedimentation (indicated by high amplitude reverse‐polarity top reflection), which is extensively deformed or completely scoured by motion of the overlying material. Within the body of the landslide, two different flow facies are identified. Inversion of these broadband (1.5–13.0 kHz) seismic data has allowed the calculation of remote physical properties (using acoustic quality factor, ), affording a depth and spatial assessment of the relationship between morphology and grain size. These remote physical properties are correlated against high‐resolution geotechnical data from core logs and FF‐CPTU profiles, identifying the slide plane as a weak, laminated, clay‐rich bed. This combined geophysical/geotechnical assessment of the landslide morphology and internal architecture supports previous work indicating a complex, multi‐stage failure. These combined data illustrate how seafloor stability is strongly influenced by a shallow subsurface structure, with geotechnical properties and lateral continuity of stratified beds acting as a primary control on slide plane depth and failure probability.
Parasitoids (Hymenoptera: Braconidae: Aphidiinae) of rabbitbrush aphids and linkage with agriculturally important pest aphids in Washington State, United States of America
Authors: Hollingbery Erin N. , Pike K.S. , Graf G. , Graf D. 
Published: August 2012

AbstractRabbitbrush, Chrysothamnus Nuttall spp. (Asteraceae), is a common perennial native shrub across the inland western United States. In the Columbia Basin growing district of Washington State, rabbitbrush is often found in close proximity to potatoes and other agronomic crops, but its value as a conservation reservoir and source of parasitoids of merit in agriculture is unknown. Here, we define the aphid parasitoids frequenting rabbitbrush, their aphid host preferences, seasonal occurrence, and linkage or association with other aphids of economic and noneconomic importance. Extensive field collections, lab-holdings, and rearings were used to explore and characterise the fauna. One new species of aphidiine parasitoid is described and illustrated: Praon cowiche Hollingbery and Pike, new species and a key to the parasitoids of rabbitbrush aphids is provided.
CD4+ T Cells Are Necessary and Sufficient To Confer Protection againstChlamydia trachomatisInfection in the Murine Upper Genital Tract
Authors: Gondek David C. , Olive Andrew J. , Stary Georg , Starnbach Michael N. 
Published: August 2012

AbstractChlamydia trachomatis infection is the most common bacterial sexually transmitted disease in the United States. Chlamydia infections that ascend to the upper genital tract can persist, trigger inflammation, and result in serious sequelae such as infertility. However, mouse models in which the vaginal vault is inoculated with C. trachomatis do not recapitulate the course of human disease. These intravaginal infections of the mouse do not ascend efficiently to the upper genital tract, do not cause persistent infection, do not induce significant inflammation, and do not induce significant CD4+ T cell infiltration. In this article, we describe a noninvasive transcervical infection model in which we bypass the cervix and directly inoculate C. trachomatis into the uterus. We show that direct C. trachomatis infection of the murine upper genital tract stimulates a robust Chlamydia-specific CD4+ T cell response that is both necessary and sufficient to clear infection and provide protection against reinfection.