bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relation between illness cognitions and quality of life in people with and without a stoma following rectal cancer treatment
Authors: Bossema Ercolie R. , Seuntiëns Marina W. M. , Marijnen Corrie A. M. , Baas‐Thijssen Monique C. M. , van de Velde Cornelis J. H. , Stiggelbout Anne M. 
Published: May 2010

AbstractObjectives: To compare health‐related quality of life, emotional functioning and illness cognitions between people with and without a stoma after rectal cancer treatment about 8 years ago and to examine the relation between illness cognitions and health‐related quality of life and emotional functioning.Methods: Sixty‐two people who had undergone abdominoperineal resection with a permanent stoma and 60 people who had undergone low anterior resection without a permanent stoma participated. Questionnaires included the European Organization of Research and Treatment of Cancer Quality of Life Questionnaire—C30, the Hospital Anxiety and Depression Scale, and the Illness Cognition Questionnaire.Results: There were no significant differences between people with and without a stoma in health‐related quality of life, emotional functioning and illness cognitions. There were moderate and significant relations between the illness cognitions helplessness (negative) and disease acceptance (positive) on the one hand and health‐related quality of life and emotional functioning on the other. For helplessness this relation barely differed between people with and without a stoma, but for disease acceptance this relation was stronger for people without a stoma than for people with a stoma.Conclusions: The study showed no differences in health‐related quality of life, but a stronger relation between disease acceptance and health‐related quality of life for people without a stoma than for people with a stoma. If this relation is causal, people with negative illness cognitions after rectal cancer treatment might be identified and offered help. Copyright © 2010 John Wiley & Sons, Ltd.
Structure, magnetic, and optical properties in Zn0.98−xCu0.02FexO diluted magnetic semiconductors
Authors: Liu Huilian , Yang Jinghai , Hua Zhong , Zhang Yongjun , Yang Lili , Wang Dandan 
Published: May 2010

AbstractCu‐doped and Cu, Fe codoped ZnO diluted magnetic semiconductors (DMSs) powders samples were synthesized by the sol–gel method. The X‐ray diffraction (XRD) results showed the Zn0.985Cu0.02O and Zn0.95Fe0.03Cu0.02O samples were of single phase with the ZnO‐like wurtzite structure. Magnetic measurements indicated that room‐temperature ferromagnetism of Zn0.98Cu0.02O was intrinsic in nature and the saturation magnetization of Zn0.98Cu0.02O DMSs increased after Fe doping. Photoluminescence (PL) measurements showed that the intensity of the ultraviolet (UV) emission band and the visible‐light emission band of Zn0.95Cu0.02Fe0.03O samples increased and the UV emission peak exhibited blue shift compared to Zn0.98Cu0.02O samples.
A coupling of rapid crystallization and plastic consolidation as a method for mass scale production of bulk submicrocrystalline aluminum alloys
Authors: Dybiec Henryk 
Published: May 2010

AbstractRapid crystallization is a well‐known method for production of ultrafine‐grained metallic materials using the overcooling effect. Unfortunately, this method provides material in dispersed form with very limited dimensions of individual particles, which must be consolidated to bulk form for engineering use. To prevent destabilization of ultrafine‐grain structure of polycrystalline particles the consolidation process should to be quick enough and must be conducted at reasonably low temperatures. Such reasons suggest the process of plastic consolidation. In this process plastic deformation of individual particles develops new surfaces in status nascendi, which is able to create strong bonds between collectively deformed particles of dispersed materials and converts the powder to the bulk form. The plastic consolidation by isothermal extrusion is the agglomeration process of plastically deformable particles without involving diffusion effects. Bulk materials with no measurable porosity are the product of this process, in which the character of interaction among individual particles of powder shows similar character to interaction at grain boundaries in polycrystalline metals.
Solution processed ZnO – Challenges in processing and performance on flexible substrates
Authors: Hoffmann Rudolf C. , Dilfer Stefan , Issanin Alexander , Schneider Jörg J. 
Published: May 2010

AbstractThin films of the semiconductor ZnO were be obtained by thermal decomposition of the complex diaqua‐bis[2‐(methoxyimino)‐propanato]‐zinc(II) to nanoscale ZnO at moderate temperatures. This single source precursor is suitable for spincoating and inkjet printing on polymer substrates like polyethylene terephtalate (PET) and polyethylene naphthalate (PEN) transparencies on which the conversion to ZnO has been performed. The influence of different drying procedures and conversion temperatures to the active semiconductor material ZnO on the film morphology and the electronic performance in field effect transistors is studied. magnified image
Differences between chloro‐carbon and hydro‐carbon precursors in low‐temperature epitaxial growth of 4H‐SiC
Authors: Kotamraju Siva , Krishnan Bharat , Koshka Yaroslav 
Published: May 2010

AbstractThe advantages of using the chlorinated carbon precursor chloromethane instead of the hydrocarbon precursor propane in low‐temperature (1300 °C) epitaxial growth of 4H‐SiC were investigated. Chloromethane was found to provide a much wider process window for variation of the C/Si ratio between the lower boundary corresponding to the formation of condensed silicon face and the upper boundary corresponding to polytype inclusions and polycrystalline degradation, which is critical for achieving high growth rates without epilayer quality degradation. Use of a high Cl/Si ratio provided by HCl addition in the propane‐based epitaxial growth did not eliminate the critical differences between chloro‐carbon and hydro‐carbon precursors. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Successful use of albuterol in a patient with central core disease and mitochondrial dysfunction
Authors: Schreuder L. T. W. , Nijhuis‐van der Sanden M. W. G. , de Hair A. , Peters G. , Wortmann S. , Bok L. A. , Morava E. 
Published: May 2010

AbstractAlbuterol, a selective beta‐adrenergic agonist, has been used experimentally in combination with exercise therapy in a few inherited neuromuscular disorders to increase muscle strength and muscle volume . We report on a 9‐year‐old boy with central core disease and mitochondrial dysfunction due to compound heterozygous RYR1 mutations receiving albuterol treatment for 1 year. Throughout the period of albuterol administration, the patient underwent an aerobic exercise regime of training sessions three times a week that lasted 20 min each. No side effects of albuterol use were seen. Significant clinical progress, including self care, sitting up, raising arms above the shoulders, independent feeding, and better speech and writing were observed compared with minimal development of these abilities in the previous years on physiotherapy. Improved forced expiratory volume in 1 s (FEV1) score was detected and increased muscle strength was noted: progress was measured using various functional tests and assessment scales. The only complication observed was a mild progression of the joint contractures, possibly due to an unbalance between the flexor and extensor musculature. In general, in this pilot study in a complex case of metabolic myopathy our patient has shown promising results following albuterol treatment and aerobic exercise therapy.
Antioxidant dysfunction: potential risk for neurotoxicity in ethylmalonic aciduria
Authors: Pedersen Christina B. , Zolkipli Zarazuela , Vang Søren , Palmfeldt Johan , Kjeldsen Margrethe , Stenbroen Vibeke , Schmidt Stinne P. , Wanders Ronald J. A. , Ruiter Jos P. N. , Wibrand Flemming , Tein Ingrid , Gregersen Niels 
Published: May 2010

AbstractMitochondrial dysfunction and oxidative stress are central to the molecular basis of several human diseases associated with neuromuscular disabilities. We hypothesize that mitochondrial dysfunction also contributes to the neuromuscular symptoms observed in patients with ethylmalonic aciduria and homozygosity for ACADS c.625G>A‐a common variant of the short‐chain acyl‐coenzyme A (CoA) dehydrogenase (SCAD) enzyme in the mitochondrial fatty acid oxidation pathway. This study sought to identify the specific factors that initiate cell dysfunction in these patients. We investigated fibroblast cultures from 10 patients with neuromuscular disabilities, elevated levels of ethylmalonic acid (EMA) (>50 mmol/mol creatinine), and ACADS c.625G>A homozygosity. Functional analyses, i.e., ACADS gene and protein expression as well as SCAD enzyme activity measurements, were performed together with a global nano liquid chromatography tandem mass spectroscopy (nano‐LC‐MS/MS)‐based screening of the mitochondrial proteome in patient fibroblasts. Moreover, cell viability of patient fibroblasts exposed to menadione‐induced oxidative stress was evaluated. Loss of SCAD function was detected in the patient group, most likely due to decreased ACADS gene expression and/or elimination of misfolded SCAD protein. Analysis of the mitochondrial proteome in patient fibroblasts identified a number of differentially expressed protein candidates, including reduced expression of the antioxidant superoxide dismutase 2 (SOD2). Additionally, patient fibroblasts demonstrated significantly higher sensitivity to oxidative stress than control fibroblasts. We propose that reduced mitochondrial antioxidant capacity is a potential risk factor for ACADS c.625G>A‐associated ethylmalonic aciduria and that mitochondrial dysfunction contributes to the neurotoxicity observed in patients.
Prevalence of pain in head and neck cancer out-patients
Authors: Williams J E , Yen J T C , Parker G , Chapman S , Kandikattu S , Barbachano Y 
Published: May 2010

AbstractBackground:This study aimed to determine the prevalence of pain, and the adequacy of its treatment, amongst patients with head and neck cancer, and to determine whether specific groups could be identified as being at risk of pain.Methods:Consecutive patients attending head and neck oncology out-patient services were surveyed.Results:The prevalence of pain was 34 per cent, lower than that found in systematic reviews. No specific risk factors for pain were identified. Particular pain problems in this population comprised a high incidence of neuropathic pain, breakthrough pain and pain of non-malignant origin.Conclusion:The prevalence of unrelieved pain was high in this study population, although no specific risk factors were found. A further study is planned to determine the effect of using a routine screening tool and an immediate pain treatment protocol in this group of patients.
Stabilizing American Society: Kenneth Boulding and the Integration of the Social Sciences, 1943–1980
Authors: Fontaine Philippe 
Published: May 2010

ArgumentFor more than thirty years after World War II, the unconventional economist Kenneth E. Boulding (1910–1993) was a fervent advocate of the integration of the social sciences. Building on common general principles from various fields, notably economics, political science, and sociology, Boulding claimed that an integrated social science in which mental images were recognized as the main determinant of human behavior would allow for a better understanding of society. Boulding's approach culminated in the social triangle, a view of society as comprised of three main social organizers – exchange, threat, and love – combined in varying proportions. According to this view, the problems of American society were caused by an unbalanced combination of these three organizers. The goal of integrated social scientific knowledge was therefore to help policy makers achieve the “right” proportions of exchange, threat, and love that would lead to social stabilization. Though he was hopeful that cross-disciplinary exchanges would overcome the shortcomings of too narrow specialization, Boulding found that rather than being the locus of a peaceful and mutually beneficial exchange, disciplinary boundaries were often the occasion of conflict and miscommunication.
Working with Asplund
Authors: Grice Michael 
Published: May 2010

In 1935 I worked for Mendelsohn and Chermayeff on the Gilbey building for three months in the summer – and Birkin Haward took me under his wing.By 1937, I'd finished my first three years at the Architectural Association and felt that I wasn't getting anywhere – producing schemes overnight. I wanted to work on real buildings.
Leisure-time physical activity and nutrition: a twin study
Authors: Rintala Mirva , Lyytikäinen Arja , Leskinen Tuija , Alen Markku , Pietiläinen Kirsi H , Kaprio Jaakko , Kujala Urho M 
Published: May 2010

AbstractObjectiveTo determine the association between long-term leisure-time physical activity/inactivity and eating behaviours in twin pairs discordant for physical activity for 30 years.DesignCo-twin control design with cross-sectional data collection using questionnaire on eating habits and 5 d food diary. Differences in eating behaviours between physically active and inactive co-twins were analysed with pairwise tests.SettingFinland.SubjectsSixteen same-sex twin pairs (seven monozygotic and nine dizygotic, mean age 60 years) discordant for physical activity, selected from the Finnish Twin Cohort on the basis of physical activity discordance for 30 years, blinded to their possible differences in eating behaviours.ResultsThe eating habits questionnaire revealed that physically active co-twins more frequently reported that it is easy to eat according to need, whereas overeating and/or restrictive eating was more common among the inactive co-twins (P = 0·035). Avoiding calories was more common among the active than inactive co-twins (P = 0·034). Based on food diaries the physically active co-twins had daily energy intake on average 15·5 kJ/kg higher than their inactive co-twins (P = 0·030). The active co-twins also had a higher intake of vitamin C (P = 0·004), total water (P = 0·044), legumes and nuts (P = 0·015) and sweets (P = 0·036), as well as a lower energy-adjusted intake of meat (P = 0·013).ConclusionsThe physically active persons seem to eat more but not necessarily healthier food. However, habitual physical activity may help in eating according to need and in reaching and maintaining a healthy body composition. Therefore, it is necessary to incorporate both dietary and physical activity advice into health counselling.
Agency and personhood at the onset of the Mycenaean period
Authors: Voutsaki Sofia 
Published: May 2010

AbstractThis paper offers a critical evaluation of the debate on agency and personhood in archaeology. Despite some very interesting and sharp discussions, the debate has suffered from the projection of anachronistic definitions of the person and an overreliance on specific ethnographic readings. In addition, little attempt is made to integrate abstract theoretical discussions with close analyses of empirical data. I would like to suggest that this should be our priority. In the second part of the paper, I will apply these ideas by examining notions of personhood and agency held by the inhabitants of the southern Greek mainland between ca 1800 and 1600 B.C. The analysis will be based on the mortuary practices and imagery of the period.
Surface-wave-enabled darkfield aperture for background suppression during weak signal detection
Authors: Zheng Guoan , Cui Xiquan , Yang Changhuei 
Published: May 2010

Sensitive optical signal detection can often be confounded by the presence of a significant background, and, as such, predetection background suppression is substantively important for weak signal detection. In this paper, we present a novel optical structure design, termed surface-wave-enabled darkfield aperture (SWEDA), which can be directly incorporated onto optical sensors to accomplish predetection background suppression. This SWEDA structure consists of a central hole and a set of groove pattern that channels incident light to the central hole via surface plasmon wave and surface-scattered wave coupling. We show that the surface wave component can mutually cancel the direct transmission component, resulting in near-zero net transmission under uniform normal incidence illumination. Here, we report the implementation of two SWEDA structures. The first structure, circular-groove-based SWEDA, is able to provide polarization-independent suppression of uniform illumination with a suppression factor of 1230. The second structure, linear-groove-based SWEDA, is able to provide a suppression factor of 5080 for transverse-magnetic wave and can serve as a highly compact (5.5 micrometer length) polarization sensor (the measured transmission ratio of two orthogonal polarizations is 6100). Because the exact destructive interference balance is highly delicate and can be easily disrupted by the nonuniformity of the localized light field or light field deviation from normal incidence, the SWEDA can therefore be used to suppress a bright background and allow for sensitive darkfield sensing and imaging (observed image contrast enhancement of 27 dB for the first SWEDA).
A low-polynomial algorithm for assembling clusters of orthologous groups from intergenomic symmetric best matches
Authors: Kristensen David M. , Kannan Lavanya , Coleman Michael K. , Wolf Yuri I. , Sorokin Alexander , Koonin Eugene V. , Mushegian Arcady 
Published: May 2010

Abstract
Motivation: Identifying orthologous genes in multiple genomes is a fundamental task in comparative genomics. Construction of intergenomic symmetrical best matches (SymBets) and joining them into clusters is a popular method of ortholog definition, embodied in several software programs. Despite their wide use, the computational complexity of these programs has not been thoroughly examined.
Results: In this work, we show that in the standard approach of iteration through all triangles of SymBets, the memory scales with at least the number of these triangles, O(g3) (where g = number of genomes), and construction time scales with the iteration through each pair, i.e. O(g6). We propose the EdgeSearch algorithm that iterates over edges in the SymBet graph rather than triangles of SymBets, and as a result has a worst-case complexity of only O(g3log g). Several optimizations reduce the run-time even further in realistically sparse graphs. In two real-world datasets of genomes from bacteriophages (POGs) and Mollicutes (MOGs), an implementation of the EdgeSearch algorithm runs about an order of magnitude faster than the original algorithm and scales much better with increasing number of genomes, with only minor differences in the final results, and up to 60 times faster than the popular OrthoMCL program with a 90% overlap between the identified groups of orthologs.
Availability and implementation: C++ source code freely available for download at ftp.ncbi.nih.gov/pub/wolf/COGs/COGsoft/
Contact: dmk@stowers.org
Supplementary information: Supplementary materials are available at Bioinformatics online.
Differential Auxin-Transporting Activities of PIN-FORMED Proteins in Arabidopsis Root Hair Cells
Authors: Ganguly Anindya , Lee Sang Ho , Cho Misuk , Lee Ok Ran , Yoo Heejin , Cho Hyung-Taeg 
Published: May 2010

Abstract
The Arabidopsis (Arabidopsis thaliana) genome includes eight PIN-FORMED (PIN) members that are molecularly diverged. To comparatively examine their differences in auxin-transporting activity and subcellular behaviors, we expressed seven PIN proteins specifically in Arabidopsis root hairs and analyzed their activities in terms of the degree of PIN-mediated root hair inhibition or enhancement and determined their subcellular localization. Expression of six PINs (PIN1–PIN4, PIN7, and PIN8) in root hair cells greatly inhibited root hair growth, most likely by lowering auxin levels in the root hair cell by their auxin efflux activities. The auxin efflux activity of PIN8, which had not been previously demonstrated, was further confirmed using a tobacco (Nicotiana tabacum) cell assay system. In accordance with these results, those PINs were localized in the plasma membrane, where they likely export auxin to the apoplast and formed internal compartments in response to brefeldin A. These six PINs conferred different degrees of root hair inhibition and sensitivities to auxin or auxin transport inhibitors. Conversely, PIN5 mostly localized to internal compartments, and its expression in root hair cells rather slightly stimulated hair growth, implying that PIN5 enhanced internal auxin availability. These results suggest that different PINs behave differentially in catalyzing auxin transport depending upon their molecular activity and subcellular localization in the root hair cell.
Similarity of pharmacodynamic effects of a single injection of insulin glargine, insulin detemir and NPH insulin on glucose metabolism assessed by 24‐h euglycaemic clamp studies in healthy humans
Authors: Sørensen L. P. , Brock B. , Mengel A. , Rungby J. , Moller N. , Nielsen S. , Vølund A. , Schmitz O. 
Published: May 2010

Diabet. Med. 27, 830–837 (2010)AbstractAims  Two long‐acting insulin analogues, insulin glargine and insulin detemir, have been developed as alternatives to neutral protamine Hagedorn (NPH) insulin, which has been the preferred basal insulin preparation for decades. The aim was to directly compare the pharmacodynamic properties of the long‐acting insulin analogues and NPH insulin after a single subcutaneous injection.Methods  The study was conducted as a double‐blind, controlled, three‐arm, crossover study including 10 healthy lean male volunteers. On three different occasions, each subject was challenged with 0.4 U kg−1 of either insulin glargine, insulin detemir or NPH insulin. Plasma glucose was maintained at 0.3 mmol l−1 below fasting level by glucose clamping for 24 h. C‐peptide, insulin, free fatty acids (FFAs) and counter regulatory hormones were measured throughout the clamp period, whereas endogenous glucose release (EGR) was assessed by isotope dilution technique (3‐3H‐glucose).Results  The mean glucose infusion rate (GIR)–time profiles revealed no significant differences between the three preparations in the primary endpoints: Maximal GIR of approximately 3.4 mg kg−1 min−1 (P = 0.68), time to maximal GIR of approximately 10 h (TRmax) (P = 0.35) and area under the GIR curve (GIRAUC) (P = 0.81). Compared with the other insulin preparations, EGR (see above)was lower for insulin detemir at the beginning of the clamp period (330–360 min) (P = 0.007) while GIR was lower (P = 0.005) and FFA concentrations were higher (P = 0.005) during the last 4 h of the clamp.Conclusions  In this experimental design, only minor pharmacodynamic differences were demonstrated between insulin detemir, insulin glargine and NPH insulin.