bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Maxillary Sinus Floor Augmentation on Sinus Membrane Thickness in Computed Tomography
Authors: Pommer Bernhard , Dvorak Gabriella , Jesch Philip , Palmer Richard M. , Watzek Georg , Gahleitner André 
Published: November 2011

Background: Little is known about maxillary sinus compliance, i.e., the intrinsic potential of the sinus membrane to resume its homeostatic status after the surgical trauma caused by sinus floor elevation. The aim of the present study is to investigate the effect of maxillary sinus floor augmentation on sinus membrane thickness.Methods: Within‐patient comparison of computed tomographic scans before bone grafting versus 4 to 6 months after bone grafting was performed. Changes in membrane thickness were evaluated in 65 maxillary sinus floor augmentation procedures via a lateral approach in 35 patients without clinical signs of sinus pathology at any time.Results: Sinus membrane thickness differed significantly before (0.8 ± 1.2 mm) versus after (1.5 ± 1.3 mm) augmentation surgery (P <0.001), with a mean increase of 0.8 ± 1.6 mm (maximum: 4.4 mm). Only 28% of augmented sinuses did not show membrane thickening. In non‐augmented control sinuses, there was no evidence of membrane thickness increase.Conclusions: The results indicate that the maxillary sinus membrane, even in healthy clinical conditions, undergoes morphologic modifications after sinus floor elevation, yet membrane reactions demonstrate significant variability. Future research on the effect of augmentation surgery on maxillary sinus physiology is recommended.
Analysis of Copper and Zinc Plasma Concentration and the Efficacy of Zinc Therapy in Individuals with Asperger's Syndrome, Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) and Autism
Authors: Russo A.J. , deVito Robert 
Published: November 2011

AimTo assess plasma zinc and copper concentration in individuals with Asperger's Syndrome, Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS) and autistic disorder, and to analyze the efficacy of zinc therapy on the normalization of zinc and copper levels and symptom severity in these disorders.Subjects and methodsPlasma from 79 autistic individuals, 52 individuals with PDD-NOS, 21 individuals with Asperger's Syndrome (all meeting DSM-IV diagnostic criteria), and 18 age and gender similar neurotypical controls, were tested for plasma zinc and copper using inductively-coupled plasma-mass spectrometry.ResultsAutistic and PDD-NOS individuals had significantly elevated plasma levels of copper. None of the groups (autism, Asperger's or PDD-NOS) had significantly lower plasma zinc concentrations. Post zinc and B-6 therapy, individuals with autism and PDD-NOS had significantly lower levels of copper, but individuals with Asperger's did not have significantly lower copper. Individuals with autism, PDD-NOS and Asperger's all had significantly higher zinc levels. Severity of symptoms decreased in autistic individuals following zinc and B-6 therapy with respect to awareness, receptive language, focus and attention, hyperactivity, tip toeing, eye contact, sound sensitivity, tactile sensitivity and seizures. None of the measured symptoms worsened after therapy. None of the symptoms in the Asperger's patients improved after therapy.DiscussionThese results suggest an association between copper and zinc plasma levels and individuals with autism, PDD-NOS and Asperger's Syndrome. The data also indicates that copper levels normalize (decrease to levels of controls) in individuals with autism and PDD-NOS, but not in individuals with Asperger's. These same Asperger's patients do not improve with respect to symptoms after therapy, whereas many symptoms improved in the autism group. This may indicate an association between copper levels and symptom severity.
Stochastic Resonance Activity Influences Serum Tryptophan Metabolism in Healthy Human Subjects
Authors: Kepplinger Berthold , Baran Halina , Sedlnitzky-Semler Brenda , Badawi Nagy-Roland , Erhart Helene 
Published: November 2011

Background Stochastic resonance therapy (SRT) is used for rehabilitation of patients with various neuropsychiatric diseases. An alteration in tryptophan metabolism along the kynurenine pathway has been identified in the central and peripheral nervous systems in patients with neuroinflammatory and neurodegenerative diseases and during the aging process. This study investigated the effect of SRT as an exercise activity on serum tryptophan metabolites in healthy subjects. Methods Serum L-tryptophan, L-kynurenine, kynurenic acid, and anthranilic acid levels were measured one minute before SRT and at one, 5, 15, 30, and 60 minutes after SRT. We found that SRT affected tryptophan metabolism. Serum levels of L-tryptophan, L-kynurenine, and kynurenic acid were significantly reduced for up to 60 minutes after SRT. Anthranilic acid levels were characterized by a moderate, non significant transient decrease for up to 15 minutes, followed by normalization at 60 minutes. Tryptophan metabolite ratios were moderately altered, suggesting activation of metabolism after SRT. Lowering of tryptophan would generally involve activation of tryptophan catabolism and neurotransmitter, protein, and bone biosynthesis. Lowering of kynurenic acid by SRT might be relevant for improving symptoms in patients with neuropsychiatric disorders, such as Parkinson's disease, Alzheimer's disease, schizophrenia, and depression, as well as certain pain conditions.
Validity of Using the Assessment of Motor and Process Skills to Determine the Need for Assistance
Authors: Merritt Brenda K. 
Published: November 2011

Abstract
OBJECTIVE. This study evaluated the validity of using Assessment of Motor and Process Skills (AMPS) measures as evidence of the need for assistance in the community.
METHOD. In a retrospective analysis of existing data (N = 64,466), receiver operating characteristic (ROC) curves were generated, and a split-sample method was used to validate the predictions.
RESULTS. When identifying people who need assistance versus those who do not need assistance in the community, activity of daily living (ADL) motor and ADL process measures have fair and good discriminating value, respectively (areas under the ROC curves were .78 and .84). Evidence supports placing ADL motor and ADL process independence cutoff measures at 1.50 logits (sensitivity = .67, specificity = .72) and 1.00 logit (sensitivity = .81, specificity = .70), respectively. Accuracy was highest when matched motor and process decisions occurred (sensitivity = .85, specificity = .83).
CONCLUSION. Evidence supports using ADL ability measures from the AMPS to provide evidence of a client’s need for assistance in the community.
Correlations Between Quality of Life and Adaptation Factors Among People With Multiple Sclerosis
Authors: Hwang Jengliang Eric , Cvitanovich Danielle C. , Doroski Erin K. , Vajarakitipongse Jessica G. 
Published: November 2011

Abstract
OBJECTIVE. We examined the correlations between quality of life and three adaptation factors—adjusted self-concept, social support, and accessibility—in people with multiple sclerosis (MS).
METHOD. A convenience sample of 68 participants completed the Leeds Multiple Sclerosis Quality of Life scale (LMSQoL) and a questionnaire assessing the three adaptation factors.
RESULTS. We found significant moderate correlations between LMSQoL scores and adjusted self-concept (r = .56, p &lt; .0001) and LMSQoL scores and social support (r = .52, p &lt; .0001); a significant low correlation was found between LMSQoL and accessibility (r = .36, p = .003).
DISCUSSION. Adjusted self-concept, social support, and accessibility were found to be critical in participants’ psychosocial adaptation to the course of MS. Occupational therapy intervention should address these adaptation factors to help clients cope with MS and promote quality of life.
Driving to Learn in a Powered Wheelchair: The Process of Learning Joystick Use in People With Profound Cognitive Disabilities
Authors: Nilsson Lisbeth , Eklund Mona , Nyberg Per , Thulesius Hans 
Published: November 2011

Abstract
The Driving to Learn project explored ways to help people with profound cognitive disabilities practice operating a joystick-operated powered wheelchair. The project used a grounded theory approach with constant comparative analysis and was carried out over 12 yr. The participants were 45 children and adults with profound cognitive disabilities. Reference groups included 17 typically developing infants and 64 participants with lesser degrees of cognitive disability. The data sources included video recordings, field notes, open interviews, and a rich mixture of literature. The findings that emerged yielded strategies for facilitating achievements, an 8-phase learning process, an assessment tool, and a grounded theory of deplateauing explaining the properties necessary for participants to exceed expected limitations and plateaus. Eight participants with profound cognitive disabilities reached goal-directed driving or higher. Participants were empowered by attaining increased control over tool use, improving their autonomy and quality of life.
Improving Measurement Properties of the Recovery Assessment Scale With Rasch Analysis
Authors: Hancock Nicola , Bundy Anita , Honey Anne , James Geoffrey , Tamsett Sally 
Published: November 2011

Abstract
Recovery from serious mental illness refers to the attainment of a meaningful, productive, and satisfying life, regardless of the presence or absence of reoccurring symptoms. A lack of psychometrically sound instruments has thwarted attempts to measure recovery. With the goal of addressing this need, we administered the Recovery Assessment Scale (RAS) to 92 people with serious mental illness attending a Clubhouse program. Clubhouses are community-based psychosocial rehabilitation programs for people living with mental illness. Rasch analysis enabled close examination of the RAS’s internal validity and reliability. Through iterative analyses, we made enhancements to the instrument where possible. The preponderance of evidence suggests that the modified RAS forms a unidimensional construct; however, the instrument remains far from a gold standard. Occupational therapy is well suited to take leadership in further development of this instrument.
Venöse Thrombembolien bei Tumorpatienten
Authors: Alt-Epping B. , Demarmels Biasutti F. , Langer F. , Wörmann B. , Riess H. , Pabinger I. 
Published: November 2011

SummaryVenous thrombembolism (VTE) is one of the most frequent complication in cancer patients. The current options in prophylaxis and therapy have to be balanced against the risks of major bleeding and the burden for the patients. The Gesellschaft für Thrombose- und Hämostaseforschung, the Deutsche Gesellschaft für Palliativmedizin and the German speaking Societies of Hematology and Oncology have recently published guidelines on VTE in cancer patients. Recommendations include diagnostics, individual prophylaxis and treatment.
Pituitary iron and volume predict hypogonadism in transfusional iron overload
Authors: Noetzli Leila J. , Panigrahy Ashok , Mittelman Steven D. , Hyderi Aleya , Dongelyan Ani , Coates Thomas D. , Wood John C. 
Published: November 2011

AbstractHypogonadism is the most common morbidity in patients with transfusion‐dependent anemias such as thalassemia major. We used magnetic resonance imaging (MRI) to measure pituitary R2 (iron) and volume to determine at what age these patients develop pituitary iron overload and volume loss. We recruited 56 patients (47 with thalassemia major, five with chronically transfused thalassemia intermedia and four with Blackfan‐Diamond syndrome) to have pituitary MRIs to measure pituitary R2 and volume. Hypogonadism was defined clinically based on the timing of secondary sexual characteristics or the need for sex hormone replacement therapy. Patients with transfusional iron overload begin to develop pituitary iron overload in the first decade of life; however, clinically significant volume loss was not observed until the second decade of life. Severe pituitary iron deposition (Z > 5) and volume loss (Z < −2.5) were independently predictive of hypogonadism. Pituitary R2 correlated significantly with serum ferritin as well as liver, pancreatic, and cardiac iron deposition by MRI. Log pancreas R2* was the best single predictor for pituitary iron, with an area under the receiving operator characteristic curve of 0.88, but log cardiac R2* and ferritin were retained on multivariate regression with a combined r2 of 0.71. Pituitary iron overload and volume loss were independently predictive of hypogonadism. Many patients with moderate‐to‐severe pituitary iron overload retained normal gland volume and function, representing a potential therapeutic window. The subset of hypogonadal patients having preserved gland volumes may also explain improvements in pituitary function observed following intensive chelation therapy. Am. J. Hematol. 2011. © 2011 Wiley Periodicals, Inc.
Nationwide incidence of major complications in endoscopic sinus surgery
Authors: Ramakrishnan Vijay R. , Kingdom Todd T. , Nayak Jayakar V. , Hwang Peter H. , Orlandi Richard R. 
Published: November 2011

AbstractBackground:Endoscopic sinus surgery (ESS) is one of the most commonly performed procedures in otolaryngology. Major complications are estimated to occur in 1–3% of cases, based on early studies with relatively small patient cohorts in academic institutions. The aim of this study was to update data regarding major complication rates associated with ESS by analyzing a large patient database.Methods:Retrospective review of a nationwide database of patients who underwent ESS between 2003 and 2007. Major postoperative complications—cerebrospinal fluid (CSF) leak, orbital injury, and hemorrhage requiring blood transfusion—were identified by searching the database for related International Classification of Diseases, 9th edition (ICD‐9) and Current Procedural Terminology (CPT) codes. Complication rates were examined and time to occurrence analyzed. Two‐tailed test of proportions, global chi‐square test, and logistical regression analysis were used for statistical comparison.Results:A total of 62,823 patients who met rigorous inclusion criteria were included. The overall major complication rate was 1.00% (CSF leak 0.17%; orbital injury 0.07%; hemorrhage requiring transfusion 0.76%). CSF leak was less likely to occur in the pediatric population (p = 0.05), whereas orbital injury was more likely to occur in children (p < 0.001). Examination of the impact of image guidance (IGS) was limited by study design.Conclusion:The incidence of major complications associated with ESS appears to have decreased since early reports over 10 years ago. There may be different complication rates in the pediatric population. Study design limitations did not allow for comprehensive assessment of IGS in the development of these complications. These data help to educate otolaryngologists and patients about complication rates in ESS in a modern context. © 2011 ARS‐AAOA, LLC.
On the general structure of mathematical models for physical systems
Authors: Delphenich D.H. 
Published: November 2011

AbstractIt is proposed that the mathematical models for any physical systems that are based in first principles, such as conservation laws or balance principles, have some common elements, namely, a space of kinematical states, a space of dynamical states, a constitutive law that associates dynamical states with kinematical states, as well as a duality principle. The equations of motion or statics then come about from, on the one hand, specifying the integrability of the kinematical state, and on the other hand, specifying a statement that is dual to it for the dynamical states. Examples are given from various fundamental physical systems.
Retracted: Palladium (II)—rare earth metal catalyzed copolymerization of CO and styrene in [bmim]+PF6− ionic liquid
Authors: Guo Jintang , Hu Guang , Gao Shan , Li Peng 
Published: November 2011

AbstractThe following article from the Journal of Applied Polymer Science, “Palladium (II)—Rare Earth Metal Catalyzed Copolymerization of CO and Styrene in [bmim]+PF6− Ionic Liquid” by Jintang Guo, Guang Hu, Shan Gao, and Peng Li, published online on 14 November 2011 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors; the journal's Managing Editor, Stefano Tonzani; and Wiley Periodicals, Inc. The retraction has been agreed due to the inappropriate use of previously published work, in particular Figures 6 and 7.
Regioregular improvement on the oxidative polymerization of poly‐3‐octylthiophenes by slow addition of oxidant at low temperature
Authors: Torres B. B. M. , Balogh D. T. 
Published: November 2011

AbstractMany pathways can be used to synthesize polythiophenes derivatives. The polycondensation reactions performed with organometallics are preferred since they lead to regioregular polymers (with high content of heat‐to‐tail coupling) which have enhanced conductivity and luminescence. However, these pathways have several steps; the reactants are highly moisture sensitive and expensive. On the other hand, the oxidative polymerization using FeCl3 is a one‐pot reaction that requires less moisture sensitive reactants with lower cost, although the most common reaction conditions lead to polymers with low regioregularity. Here, we report that by changing the reaction conditions, such as FeCl3 addition rate and reaction temperature, poly‐3‐octylthiophenes with different the regioregularities can be obtained, reaching about 80% of heat‐to‐tail coupling. Different molar mass distributions and polydispersivities were obtained. The preliminary results suggest that the oxidative polymerization process could be improved to yield polythiophenes with higher regioregularity degree and narrower molar mass distributions by just setting some reaction conditions. We also verified that it is possible to solvent extract part of the lower regioregular fraction of the polymer further improving the regioregularity degree. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Chain extension reactions of unsaturated polyesters with bis(2‐oxazoline)s
Authors: Taylan Ediz , Küsefoğlu Selim H. 
Published: November 2011

AbstractTwo different bisoxazolines, 2,2′‐(1,3‐phenylene) bis(2‐oxazoline) (1,3‐PBO) and 2,2′‐bis(2‐oxazoline) (BO) were investigated as chain extenders for short chain unsaturated polyesters (UPEs). These extenders reacted readily with carboxyl ends of unsaturated polyesters, leading to rapid molecular weight increase through coupling of oligomeric chains. Commercially available unsaturated polyesters commonly have molecular weights around 1500, usually reached after a 20‐h polyesterification reaction. When bisoxazolines were reacted with short UPE chains obtained at the 6th hour of a commercial polyesterification reaction, the molecular weight of UPE reached 1500 within 5–30 min, which provides economies and prevents the glycol loss and yellowing which are associated with extended reaction times. Styrene solubility, gel time, and thermal and mechanical properties of the chain extended polyesters remained comparable to the commercial UPE, with 8–10 min of gel time and a storage modulus about 3000 MPa. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Adaptive Fuzzy Control for Nonlinear Time‐Delay Systems with Dynamical Uncertainties
Authors: Tong Shaocheng , Sheng Ning , Li Yongming 
Published: November 2011

AbstractIn this paper, an adaptive fuzzy backstepping robust control approach is proposed for a class of SISO nonlinear strict‐feedback systems. The nonlinear systems addressed in this paper are assumed to possess three uncertainties: (i) the unstructured uncertainties; (ii) the time delays; and (iii) the dynamics uncertainties. In adaptive backstepping recursive design, fuzzy logic systems are used to approximate the unstructured uncertainties. A nonlinear damping technique and Lyapunov–Krasovskii functions are introduced to cancel the effects of the dynamics uncertainties and deal with the time delays, respectively. Combining the backstepping technique and a small gain approach, a stable adaptive fuzzy robust control approach is developed. It is proved that all the signals of the closed‐loop system are semi‐golablly uniformaly ultimately bounded (SUUB). The effectiveness of the proposed approach is illustrated by a simulation example.
Modeling and design of optimal flow perfusion bioreactors for tissue engineering applications
Authors: Hidalgo‐Bastida L. Araida , Thirunavukkarasu Sundaramoorthy , Griffiths Sarah , Cartmell Sarah H. , Naire Shailesh 
Published: November 2011

AbstractPerfusion bioreactors have been used in different tissue engineering applications because of their consistent distribution of nutrients and flow‐induced shear stress within the tissue‐engineering scaffold. A widely used configuration uses a scaffold with a circular cross‐section enclosed within a cylindrical chamber and inlet and outlet pipes which are connected to the chamber on either side through which media is continuously circulated. However, fluid‐flow experiments and simulations have shown that the majority of the flow perfuses through the center. This pattern creates stagnant zones in the peripheral regions as well as in those of high flow rate near the inlet and outlet. This non‐uniformity of flow and shear stress, owing to a circular design, results in limited cell proliferation and differentiation in these areas. The focus of this communication is to design an optimized perfusion system using computational fluid dynamics as a mathematical tool to overcome the time‐consuming trial and error experimental method. We compared the flow within a circular and a rectangular bioreactor system. Flow simulations within the rectangular bioreactor are shown to overcome the limitations in the circular design. This communication challenges the circular cross‐section bioreactor configuration paradigm and provides proof of the advantages of the new design over the existing one. Biotechnol. Bioeng. 2012; 109:1095–1099. © 2011 Wiley Periodicals, Inc.
Differential contribution of Neurog1 and Neurog2 on the formation of cranial ganglia along the anterior‐posterior axis
Authors: Takano‐Maruyama Masumi , Chen Yiju , Gaufo Gary O. 
Published: November 2011

AbstractBackground: The neural crest (NC) and placode are transient neurogenic cell populations that give rise to cranial ganglia of the vertebrate head. The formation of the anterior NC‐ and placode‐derived ganglia has been shown to depend on the single activity of either Neurog1 or Neurog2. The requirement of the more posterior cranial ganglia on Neurog1 and Neurog2 is unknown. Results: Here we show that the formation of the NC‐derived parasympathetic otic ganglia and placode‐derived visceral sensory petrosal and nodose ganglia are dependent on the redundant activities of Neurog1 and Neurog2. Tamoxifen‐inducible Cre lineage labeling of Neurog1 and Neurog2 show a dynamic spatiotemporal expression profile in both NC and epibranchial placode that correlates with the phenotypes of the Neurog‐mutant embryos. Conclusion: Our data, together with previous studies, suggest that the formation of cranial ganglia along the anterior‐posterior axis is dependent on the dynamic spatiotemporal activities of Neurog1 and/or Neurog2 in both NC and epibranchial placode. Developmental Dynamics 241:229–241, 2012. © 2011 Wiley Periodicals, Inc.