bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential impact of asparaginase discontinuation on outcomes of children with T‐cell acute lymphoblastic leukemia and T‐cell lymphoblastic lymphoma
Authors: Ishida Hisashi , Imamura Toshihiko , Kobayashi Ryoji , Hashii Yoshiko , Deguchi Takao , Miyamura Takako , Oda Megumi , Yamamoto Masaki , Okada Keiko , Sano Hideki , Koh Katsuyoshi , Yuza Yuki , Watanabe Kenichiro , Nishimura Noriyuki , Takimoto Tetsuya , Moriya‐Saito Akiko , Sekimizu Masahiro , Suenobu Souichi , Sunami Shosuke , Horibe Keizo 
Published: June 2024

AbstractBackgroundAsparaginase is essential for treating T‐cell acute lymphoblastic leukemia (T‐ALL). Despite the ongoing debate on whether T‐ALL and T‐cell lymphoblastic lymphoma (T‐LBL) are the same disease entity or two distinct diseases, patients with T‐LBL often receive the same or similar treatment protocols as those with T‐ALL.MethodsThe outcomes of patients with or without L‐asparaginase discontinuation were retrospectively analyzed among four national protocols: Japan Association of Childhood Leukemia Study (JACLS) ALL‐02 and ALL‐97 for T‐ALL and Japanese Pediatric Leukemia/Lymphoma Study Group ALB‐NHL03 and JACLS NHL‐98 for T‐LBL. The hazard ratio (HR) was calculated with the Cox regression model by considering L‐asparaginase discontinuation as a time‐dependent variable.ResultsIn total, 199 patients with T‐ALL, and 133 patients with T‐LBL were included. L‐asparaginase discontinuation compromised event‐free survival (EFS) of T‐ALL patients (ALL‐02: HR 3.32, 95% confidence interval [CI] 1.40–7.90; ALL‐97: HR 3.39, 95%CI 1.19–9.67). Conversely, EFS compromise was not detected among T‐LBL patients (ALB‐NHL03: HR 1.39, 95%CI 0.41–4.68; NHL‐98: HR 0.92, 95%CI 0.11–7.60).ConclusionThe effects of L‐asparaginase discontinuation differed between T‐ALL and T‐LBL. We assume that the differential impact results from (1) the inherent differential response to L‐asparaginase between them and/or (2) a less stringent assessment of early treatment response in T‐LBL than in T‐ALL. Given the poor salvage rate of refractory or relapsed T‐ALL and T‐LBL, optimization of the frontline therapy is critical, and the current study provides a new suggestion for further treatment modifications. However, larger studies in contemporary intensified treatment protocols are required.
Trajectories of squamous cell carcinoma antigen and outcomes of patients with advanced penile cancer after chemotherapy based on paclitaxel, ifosfamid, and cisplatin regimen
Authors: Ma Nan , Gan Yi‐Xiang , Chao Yin‐Yao , Liu Zhen‐Hua , Chen Xian‐Da , Yao Kai , Han Hui , Guo Sheng‐Jie 
Published: June 2024

AbstractIntroductionPenile cancer (PC) is a lethal malignancy with no effective prognostic biomarker. We aim to investigate associations between trajectories of squamous cell carcinoma antigen (SCC‐A) and patient outcomes after chemotherapy based on paclitaxel, ifosfamid, and cisplatin (TIP) regimen.MethodsConsecutive AJCC staging III/IV PC patients who received TIP chemotherapy and repeated SCC‐A measurements in 2014–2022 were analyzed. Latent class growth mixed (LCGM) models were employed to characterize patients' serum SCC‐A trajectories. Patient survival, and clinical and pathological tumor responses were compared. Inverse probability treatment weighting was used to adjust confounding factors.ResultsEighty patients were included. LCGM models identified two distinct trajectories of SCC‐A: low‐stable (40%; n = 32) and high‐decline (60%; n = 48). Overall survival (HR [95% CI]: 3.60 [1.23–10.53], p = 0.019), progression‐free survival (HR [95% CI]: 11.33 [3.19–40.3], p < 0.001), objective response rate (37.5% vs. 62.5% p = 0.028), disease control rate (60.4% vs. 96.9% p < 0.00), and pathological complete response rate (21.2% vs. 51.9%, p = 0.014) were significantly worse in the high‐decline arm.ConclusionPC patients' SCC‐A change rate was associated with tumor response and patient survival after TIP chemotherapy. SCC‐A might assist tumor monitoring after systemic therapies.
The impact of particle size distribution of haematite‐based drilling fluid on perlite functionality
Authors: Al Jaber Jaber , Bageri Badr , Alshehri Yazeed , Otain Waleed 
Published: June 2024

AbstractDrilling fluid additives are essential in formulating an optimal mud composition for the desired geological formation. They provide different functions that enable the drilling process to reach a target zone. However, the effectiveness of these additives may be limited under certain conditions. The physical attributes of the weighting material additives such as solid particle size (particle size distribution [PSD]). The PSD can influence multiple drilling fluid properties, including the rheology, filtration, and filter cake properties. This work examined the performance of perlite when incorporated into water‐based mud with three different grades of haematite particle sizes. The investigation focused on the rheological properties, filtration, and filter cake characteristics utilizing two distinct filtration mediums: the ceramic disk and core sample. The results indicated that the PSD minimally impacts the filtration and the filter cake properties when the pore distribution of the filtration medium is uniform at low drilling mud density. However, a more pronounced effect was observed when core samples were utilized during the filtration test, reflecting the variation in pore distribution. Remarkably, perlite exhibited exceptional effectiveness in improving the drilling fluid properties. Its influence became particularly evident when core samples were employed as the filtration medium, demonstrating resilience against changes in both filtration medium pore distribution and haematite‐varied particle size grades. In this case, maximum improvements of 69%, 84%, and 86% were achieved in filtration volume, filter cake thickness, and filter cake permeability, respectively. Perlite showed an excellent performance at varied conditions represented by filtration medium and weighting material PSD.
Six‐Coordinated CoII Single‐Molecule Magnets: Synthetic Strategy, Structure and Magnetic Properties
Authors: Wang Mengmeng , Han Zongsu , Garcia Yann , Cheng Peng 
Published: June 2024

AbstractThe pursuit of molecule‐based magnetic memory materials contributes significantly to high‐density information storage research in the frame of the ongoing information technologies revolution. Remarkable progress has been achieved in both transition metal (TM) and lanthanide based single‐molecule magnets (SMMs). Notably, six‐coordinated CoII SMMs hold particular research significance owing to the economic and abundant nature of 3d TM ions compared to lanthanide ions, the substantial spin‐orbit coupling of CoII ions, the potential for precise control over coordination geometry, and the air‐stability of coordination‐saturated structures. In this review, we will summarize the progress made in six‐coordinated CoII SMMs, organized by their coordination geometry and molecular structure similarity. Valuable insights, principles, and new mechanism gleaned from this research and remaining issues that need to be addressed will also be discussed to guide future optimization.
Does Aromaticity Play a Role in Electronic and Structural Properties of YBn (n=2–14) Clusters?
Authors: Gallegos Miguel , Guevara‐Vela José Manuel , Costales Aurora , Rocha‐Rinza Tomás , Pendás Ángel Martín 
Published: June 2024

AbstractNanoclusters exhibit electronic, optical, and magnetic properties that differ significantly from those of extended and molecular systems with comparable stoichiometries. In this work, we examined the structural, energetic, and electronic characteristics of yttrium‐doped boron clusters (YBn, where n ranges from 2 to 14) with the aid of robust wavefunction analysis tools. Special emphasis is placed on the elucidation of the potential aromatic character exhibited by the resultant molecules and how it can affect their chemical bonding and stability. Our results revealed that the YBn stability is governed by the maximization of the ionic Y−B interactions. This circumstance is evidenced from the lowest‐energy conformations, which manifest as half‐sandwich structures wherein the majority of boron atoms are bonded to yttrium. The stabilization of such chemical contacts comes at the expense of a notorious depletion of the Y local electron density, crystallizing in a considerable ionic character, close to Y2++
. Such a prominent charge transfer is coupled to the enhancement of the electron delocalization within the Bn lattice, resulting in quite remarkable local and global aromatic characters. Altogether, this study shows how the toolkit of real space chemical bonding descriptors can offer valuable insights into the structural and electronic properties, along with the chemical bonding, of YBn clusters, contributing to a more comprehensive understanding of their behavior.
Self‐help or self‐sabotage? A common invader's soil legacy does not impede, and may facilitate, potential competitors
Authors: Lee Katie , Endriss Stacy B. , Blossey Bernd 
Published: June 2024

AbstractIntroduced plants create lasting abiotic and biotic changes to soil that are increasingly implicated as major drivers of invasion success, yet models for investigating patterns in the impacts of these soil legacies are lacking. Here, we used Bohemian knotweed (Reynoutria × bohemica) to present a novel approach for testing whether accounting for diverse evolutionary drivers can clarify how an invader's soil legacy mediates its success. For most tested species, R. × bohemica's soil legacy did not influence seedling performance irrespective of its evolutionary history or the evolutionary novelty of species that share its soil. However, we found the relative importance of legacy effects versus other mechanisms of invader dominance depends on the life stage of the plants growing in soil conditioned by the invader. While the effects of R. × bohemica's soil legacy on seedling performance were context dependent, emergence was, on average, higher in R. × bohemica‐conditioned soils than in unconditioned soils. Thus, contrary to theory, R. × bohemica's soil legacy not only fails to impede potential competitors but may also facilitate them. Our results are particularly powerful: we detected novel insights in the face of biological complexity, even for R. × bohemica, which likely does not depend on heterospecific plant–soil feedbacks for its competitive dominance in its introduced range. Designing rigorous investigations that explore how plant species' evolutionary histories mediate an invader's soil legacy across diverse abiotic environments, as shown here, is key for producing insights in other systems.
Complexities of treating co‐morbidities in heart failure with preserved ejection fraction
Authors: Žlahtič Tadej , Mrak Miha , Žižek David 
Published: June 2024

AbstractAtrial fibrillation and heart failure with preserved ejection fraction (HFpEF) are frequent concomitant diseases sharing several pathophysiological mechanisms leading to structural remodelling of both atria and ventricles. We present a case of an HFpEF patient with rapid atrial fibrillation who remained symptomatic even after successful cardioversion, initiation of antiarrhythmic therapy, and treatment of comorbidities. Due to asymmetric septal hypertrophy, the stress test was performed to exclude outflow tract obstruction and revealed a low basal heart rate with significant chronotropic insufficiency. In addition to SGLT2 initiation, the beta‐blocker dose was reduced, and amiodarone was discontinued. This therapy modification led to a marked improvement in exercise capacity, significant reduction of palpitations, reduction of NT‐proBNP, and signs of a decreased left ventricular filling pressure with reverse remodelling of LA. This case shows the importance of both individual tailoring of medical therapy and chronotropic insufficiency in HFpEF patients.
Determining female‐specific high‐intensity activity GPS thresholds in women's rugby union: Use of current use of male‐derived absolute speed thresholds underestimates true levels
Authors: Bradley Eddie , Roberts Jenny , Archer David 
Published: June 2024

AbstractGPS speed thresholds in women's rugby union are usually based on data derived from the men's game. However, evidence suggests the maximum speeds achieved by female players are 2–8 km.h−1 slower and the volume of high‐intensity running (HIR) in women's rugby may be underestimated. The aim of the study was to examine the effect of adjusting absolute thresholds on the volume of high‐intensity locomotion. GPS units recorded movement data from 58 players across 18 English Premier15 s matches. Distance in HIR and sprint (Spr) zones were calculated using male‐derived criteria: AbsMale (HIR >18 km.h−1; Spr ≥21 km.h−1). Two alternative thresholds were compared: AbsFVmax (HIR >16 km.h−1; Spr ≥19 km.h−1); AbsFemale (HIR >14 km.h−1; Spr ≥17 km.h−1). Data were analysed using one‐way ANOVA and effect sizes to determine differences in distances between thresholds. AbsMale HIR and Spr distances were 63 ± 71 m and 30 ± 53 m. Significantly greater distances at higher‐intensity speeds were observed with female‐adjusted thresholds. AbsFVmax: HIR: 139 ± 116 m (p = 0.01, ES 0.80); Spr: 60 ± 90 m (p = 0.131, ES 0.41) and AbsFemale: HIR: 239 ± 157 m (p < 0.01, ES 1.45); Spr: 137 ± 152 m (p < 0.01, ES 0.94). 24 players (41%) achieved speeds greater than the 21 km·h−1 threshold with the male‐derived thresholds. At AbsFVmax threshold this increased to 44 (76%) and 100% at the AbsFemale threshold. Existing male‐derived thresholds appear to underestimate high‐intensity locomotion of female players. With adjusted thresholds, specifically the AbsFemale, the proportional volume of high‐intensity activity in the women's game (8.2% total distance) aligns more closely to that observed during men's match‐play.
A kinetic analysis of four high velocity, horizontally focused step‐up variations for acceleration training
Authors: Glassbrook Daniel J. , Dorman Chris A. , Doyle Tim L.A. , Wade Jarrod A. , Fuller Joel T. 
Published: June 2024

AbstractStep‐up variations are frequently used in sports performance to develop coordinated and powerful movements that transfer to running. This study aimed to quantify the kinetic characteristics of the first foot contact of four different step‐up variations. Ten professional rugby league players participated in this study and performed the Barbell One Box Step‐Up with Catch (BB1), Barbell Two Box Step‐Up (BB2), Vest Two Box Run (VEST) and Step‐Up Jump (JUMP) as part of routine in‐season strength training sessions during one season. Peak force, total impulse and maximal rate of force development (RFD) were measured from first foot contact on the step‐up box. Significantly greater peak force and RFD were observed in JUMP than any other variation (standardized mean difference; SMD: 3.9–5.5; p < 0.001). Total impulse was equal between JUMP and BB1, and significantly greater in JUMP than BB2 and VEST (SMD: 1.3–2.3; p < 0.001), and in BB1 than BB2 and VEST (SMD: 1.8–2.8; p < 0.001). Significantly larger peak force and RFD were observed in BB2 and VEST than BB1 (SMD: 0.6–0.7) and in total impulse in BB2 than VEST (SMD: 1.6) (p < 0.05). The results of this study highlight that step‐up exercise variations maximize different kinetic characteristics, which may transfer differently to athlete running performance.
Two‐dimensionalization of 3D perovskites for passive narrowband Photodetection
Authors: Song Xin , Liu Siwen , Ren Lizhi , Zuo Yunxian , Wang Shimin , Wang Erjing , Qian Jin , Ye Tao , Wang Kai , Wu Congcong 
Published: June 2024

AbstractIn the rapidly advancing field of information technology, passive sensors with the exemption of external power input can serve as intelligent instruments for end‐node data acquisition. 3D perovskites have been recognized as a superior optoelectronic material but suffering from notorious instability due to their “soft lattice” nature. Replacing by their 2D counterparts in these photo‐sensing applications can boost the reliability level. However, traditional fabrication for 2D perovskite relay on wet chemistry methods, exhibiting complication, and inefficiency in making high‐quality films for device integration. This study unveils a new solid–solid conversion routing toward a direct transformation from 3D orientated films into 2D highly crystalline configuration, based on a spontaneous lattice regulation mechanism through an amine steam treatment. The resultant 2D film exhibits greater orientational micromorphology and a distinct monochromatic narrowband light sensing behavior after integration into a self‐powered photodetector. This method on perovskite conversion bears the promise of advanced future‐manufacturing for high‐performance photonic sensing.image
Solute export patterns across the contiguous USA
Authors: Kincaid Dustin W. , Underwood Kristen L. , Hamshaw Scott D. , Li Li , Seybold Erin C. , Stewart Bryn , Rizzo Donna M. , Haq Ijaz Ul , Perdrial Julia N. 
Published: June 2024

AbstractUnderstanding controls on solute export to streams is challenging because heterogeneous catchments can respond uniquely to drivers of environmental change. To understand general solute export patterns, we used a large‐scale inductive approach to evaluate concentration–discharge (C–Q) metrics across catchments spanning a broad range of catchment attributes and hydroclimatic drivers. We leveraged paired C–Q data for 11 solutes from CAMELS‐Chem, a database built upon an existing dataset of catchment and hydroclimatic attributes from relatively undisturbed catchments across the contiguous USA. Because C–Q relationships with Q thresholds reflect a shift in solute export dynamics and are poorly characterized across solutes and diverse catchments, we analysed C–Q relationships using Bayesian segmented regression to quantify Q thresholds in the C–Q relationship. Threshold responses were rare, representing only 12% of C–Q relationships, 56% of which occurred for solutes predominantly sourced from bedrock. Further, solutes were dominated by one or two C–Q patterns that reflected vertical solute–source distributions. Specifically, solutes predominantly sourced from bedrock had diluting C–Q responses in 43%–70% of catchments, and solutes predominantly sourced from soils had more enrichment responses in 35%–51% of catchments. We also linked C–Q relationships to catchment and hydroclimatic attributes to understand controls on export patterns. The relationships were generally weak despite the diversity of solutes and attribute types considered. However, catchment and hydroclimatic attributes in the central USA typically drove the most divergent export behaviour for solutes. Further, we illustrate how our inductive approach generated new hypotheses that can be tested at discrete, representative catchments using deductive approaches to better understand the processes underlying solute export patterns. Finally, given these long‐term C–Q relationships are from minimally disturbed catchments, our findings can be used as benchmarks for change in more disturbed catchments.
The experiences and outcomes of Gypsy, Roma, and Traveller pregnant people in pregnancy: A scoping review
Authors: O'Brien M. , Dempsey B. , Higgins M. F. 
Published: June 2024

AbstractBackgroundWithin Europe, Roma, Gypsy, and Traveller groups have been marginalized and discriminated against by larger society. Persecution and displacement have resulted in high rates of unemployment, reduced access to education, and poorer health, with significantly increased risk of poverty compared with the general population. In pregnancy, there appears to be a gap in the literature surrounding the experiences and outcomes of pregnant people within these ethnic groups.ObjectivesThe aim of this study was therefore to scope published research, specifically questioning “What is the experience of Roma Gypsy and Traveller pregnant people who access maternity care?” and “What are the obstetric outcomes within these groups?”Search StrategyThis review followed frameworks proposed by Arksey and O'Malley, Levac, and the Joanna Brigg's Institute. The PRISMA extension for Scoping Reviews (PRISMA‐ScR) tool was used. The search strategy and specific terms were chosen using the population–concepts–context framework.Selection CriteriaTitles and abstracts were reviewed independently by two reviewers. Inclusion and exclusion criteria were defined to set clear guidance for reviewers to identify appropriate studies.Data Collection and AnalysisFive electronic databases were searched (CINAHL, EMBASE, MEDLINE [OVID] Web of Science and SCOPUS). A charting form was developed to record key characteristics systematically and uniformly from the studies.Main ResultsFive themes were identified: systemic issues, antenatal care, complications of pregnancy, birth experience, and postnatal care. Systemic issues included racism, barriers to care, and adapted antenatal care. Antenatal issues included teenage pregnancy, smoking, risk of venous thrombus embolism, dietary issues, risk of communicable diseases, domestic violence, and mental health concerns. Increased risks of congenital abnormalities, growth restriction, premature labor, and perinatal and early childhood mortality were identified. For Roma women, negative birth experiences were reported, whereas the experiences of Traveller women varied.ConclusionsThe findings identified in this study serve to create a framework upon which healthcare providers can tailor the way in which pregnant people from a Roma, Gypsy, or Irish Traveller background are cared for. Using such a framework would hopefully begin to reduce the systematic marginalization and discrimination of these minorities.
Exploring pregnancy‐related stigma experiences among adolescents in rural Uganda
Authors: Sakakibara Koichi , Murray Sarah McIvor , Arima Ethan Godwills , Ojuka Caesar , Familiar‐Lopez Itziar 
Published: June 2024

AbstractIntroductionPregnant adolescents face multiple adverse experiences that vary by context due to pregnancy‐related stigma. We explored experiences of pregnancy‐related stigma and psychosocial issues among adolescents living in rural eastern Uganda.MethodsWe conducted in‐depth semi‐structured interviews with 15 adolescents (15–19 years old) who were pregnant (>3 months) or had recently given birth (<3 months) at Tororo District Hospital in Uganda. All interviews were translated from Dhopadhola to English. Thematic analysis was conducted to identify major themes, which were interpreted using the Health Stigma and Discrimination Framework.ResultsSix key themes were identified and were organized under the Health Stigma and Discrimination Framework. Social and gender norms for adolescent women and their lack of autonomy were identified as drivers and facilitators of pregnancy‐related stigma. Results show how stigma is experienced by adolescents through the lack of social support, multiple forms of abuse, and negative judgement. Such manifested stigma negatively impacted their psychosocial wellbeing and resulted in limited access to socioeconomic resources and educational opportunities.ConclusionThis study acknowledges the multilevel nature of pregnancy‐related stigma among adolescents in the context of existing policy and programming. Recognizing the impact of pregnancy‐related stigma on the health and wellbeing of adolescent girls necessitates prioritizing comprehensive stigma reduction interventions that address main drivers and facilitators, and that are rooted in the communities to harness support.
The stability and economic relevance of output gap estimates
Authors: Barbarino Alessandro , Berge Travis J. , Stella Andrea 
Published: June 2024

SummaryOutput gaps that are estimated in real time can differ substantially from those estimated after the fact. We provide a comprehensive comparison of real‐time output gap estimates, with the aim of understanding this real‐time instability. Using a statistical decomposition, we find that including Okun's law relationship improves real‐time stability by alleviating the end‐point problem. Models that include the unemployment rate also produce output gaps with relevant economic content.