bluuebunny/crossref_metadata_2025_split huggingface dataset:
Model Pembelajaran Somatic, Auditory, Visual, Intellectual untuk Kemampuan Pemahaman Matematis Siswa SMK
Authors: Mahardika Dhita Ayu , Gumilar Agung Cahya , Retnaningrum Elly 
Published: June 2024

Proses pembelajaran yang disajikan guru dipandang belum merangsang siswa untuk mengoptimalkan seluruh indra yang dimilikinya. Perlu model/strategi pembelajaran yang mampu mengoptimalkan seluruh indra siswa sehingga proses pembelajaran lebih optimal yang berdampak terhadap optimalnya pemahaman siswa. Penelitian ini merupakan penelitian kuantitatif, kuasi eksperimen, pretest-posttest control group design, dimana populasinya adalah siswa kelas X di salah satu SMK di Bandung, dan dengan menggunakan teknik purposif sampling maka diperoleh sampel kelas X AKL 2 dan X AKL 3. Kelas X AKL 2 sebagai kelas eksperimen dan X AKL 3 sebagai kelas kontrol. Metode penelitian adalah metode eksperimen dengan menggunakan uji independent sample t-test. Hasil penelitian menunjukkan bahwa model pembelajaran Somatic, Auditory, Visual, Intellectual berpengaruh terhadap kemampuan pemahaman matematis siswa di SMK; dan model pembelajaran Somatic, Auditory, Visual, Intellectual memiliki pengaruh yang lebih baik dibandingkan dengan model pembelajaran konvensional dalam meningkatkan kemampuan pemahaman matematis siswa SMK.
The learning process presented by the teacher is seen as not stimulating students to optimize all their senses. Learning models/strategies are needed that can optimize all of the student's senses so that the learning process is more optimal which has an impact on optimal student understanding. This research is a quantitative, quasi-experimental, pretest-posttest control group design, where the population is students of class X at an SMK in Bandung, and by using a purposive sampling technique, samples of class X AKL 2 and X AKL 3 are obtained. Class X AKL 2 is the experimental class and X AKL 3 is the control class. The research method is an experimental method using an independent sample t-test. The results showed that the Somatic, Auditory, Visual, and Intellectual learning models affected students' mathematical understanding abilities in SMK; and Somatic, Auditory, Visual, and Intellectual learning models have a better effect compared to conventional learning models in improving the mathematical understanding abilities of SMK students.
The Influence of Ultraviolet-A on Indicators of Plant Stress in Cannabis Sativa
Authors: Muir-Guarnaccia Jillian 
Published: June 2024

<p>The economic value of Cannabis sativa is influenced by inflorescence quality. Exposure to ultraviolet light (UV) has been shown to increase concentrations of Δ9-tetrahydrocannabinolic acid in drug-type plants. High doses of UV-B are physiologically damaging and this damage is theorized to be repaired photo-enzymatically, through exposure to white light or UV-A light. I assessed chlorophyll content, stomatal conductance, sexual lability, vegetative biomass, floral biomass, Δ9-tetrahydrocannabinol and cannabidiol content in C. sativa using light emitting diodes (LED) receiving 4h of UV-B alone or with 6h UV-A daily for five weeks. Significant (or interactive) effects of UV-A were not detected for any trait measured. However, plants exposed to UV-A+B showed a negative correlation between stomatal size and density, not seen under UV-B, suggesting UV-A impacts stomatal physiology. Results suggest a limited impact of UV-A exposure when white light is sufficient. Alternatively, further environmental variables may have obscured any effects from UV-A exposure. Keywords: </p>
Opportunities and Barriers to the Delivery of Place-based Environmental Education During Emergency and Non-emergency Teaching: An Information and Communication Technology Approach
Authors: Borisenoka Inga 
Published: June 2024

<p>Place-based environmental education (PBEE) can enrich environmental education outcomes for youth through direct contact with nature. However, PBEE in K-12 can face barriers, some of which have been exacerbated during emergency teaching protocols, as observed during the COVID-19 pandemic. This research investigates K-12 teachers' perspectives on the potential of leveraging information and communication technology (ICT) to support PBEE during emergency and non-emergency teaching. Survey (n=122) and focus group (n=24) findings identify barriers and opportunities to PBEE before and after emergency protocols and how teachers view the use of ICT in PBEE. There was a negative association between PBEE frequency and grade level taught. The emergency protocols decreased time availability to plan for PBEE due to other work responsibilities. There were more references about potential positive aspects of ICT in PBEE than negative. Nevertheless, teachers emphasized that ICT use should be intentional and limited to allow students to engage thoroughly with the environment. </p>
Investigating the Effectiveness of Equine-assisted Therapy on Children Regardless of Their Mental Disorder
Authors: Ágoston Dorottya , Bozori Gabriella , Kiss Rita Mária 
Published: June 2024

Equine-assisted therapy (EAT) is a common and popular complementary and alternative therapy among children with different mental disorders. In this study, the effectiveness of EAT was investigated on children with diverse mental disorders by analyzing their gait. Fifty-six children (age: 8.30 ± 3.77 years) were involved in the research who participated weekly in equine-assisted therapy during a school year. The gait of the children was measured twice with the GAITRite® pressure-sensing mat, before and after the therapy period. The participants did ten sections of walking on the pressure-sensing mat. Twenty-one spatial and temporal gait parameters were chosen and evaluated for further statistical analysis. To determine the normal distribution of the parameters, the Lilliefors normality test was carried out. Depending on the result, the paired t test or the Wilcoxon signed-rank test was used to compare the means of the results of the two measurements (p < 0.05). Significant differences were observed for eight out of the twenty-one parameters which investigation provides some promising results regarding the benefits of equine-assisted therapy for children's quality of life.
SOSIALISASI PENGOLAHAN MINYAK JELANTAH MENJADI SABUN CUCI
Authors: Hermansyah Amir  , Hersy Khosyati  , Intan Putri Utami  , Nining Febri Busraningsih  , Novri Hemdi Saputra  , Okta Rahmadany Arkanshi  , Perti Ulandari  , Ranti Oktiandi  , Sekar Chairunisa Regianti  , Shelvyna Woulandari  , Yenni Anggriani  
Published: June 2024

Kegiatan pengabdian kepada Masyarakat dilakukan di JL. Melinjo RT 01 RW.01 Kel. Kandang Kota Bengkulu, dengan peserta para ibu-ibu PKK. Kegiatan ini bertujuan untuk memberikan informasi tentang pemanfaatan limbah minyak jelantah sebagai bahan baku produk sabun yang bernilai dan episien untuk rumah tangga. Kegiatan dilakukan melalui sosialisai pembuatan produk sabun. Kegiatan diikuti oleh 20 orang ibu-ibu PKK RT 01 RW.01 Kel. Kandang Kota Bengkulu pada tanggal 27 April 2024 yang menunjukkan antusiasme terhadap sosialisasi yang ditampilkan. Diharapkan hasil sosialisasi yang dilakukan memberikan gambaran kepada masyarakat khususnya para ibu-ibu dilingkungan RT 01 RW.01 Kel. Kandang Kota Bengkulu untuk pengoptimalan limbah minyak jelantah yang ada . Selain itu, kegiatan ini dapat menjadi kegiatan yang produktif dan memperdayakan masyarakat untuk mengolah dan memproduksi sabun dari limbah minyak jelantah serta diharapkan berdampak positif karena dapat memberikan alternative untuk menanggulangi penumpukan sampah dan pembuangan limbah yang tidak tepat, serta dapat membuka peluang usaha baru guna meningkatkan perekonomian masyarakat.
Kata kunci: minyak jelantah, sabun, penanggulangan limbah
Budget impact analysis of natalizumab biosimilar on pharmaceutical expenditure for the treatment of relapsing-remitting multiple sclerosis in Italy
Authors: Bergamaschi Roberto , Capobianco Marco , Ravasio Roberto 
Published: June 2024

Background: The availability of high-efficacy disease-modifying therapy (DMT), including natalizumab, improved treatment efficacy in adults with highly-active relapsing-remitting multiple sclerosis (RRMS). Natalizumab patent protection has expired, and the natalizumab biosimilar (Tyruko®) has been recently reimbursed by AIFA. As the price of natalizumab biosimilar is expected to be lower as compared with natalizumab originator’s price, a budget impact analysis was conducted to assess the economic impact associated to the introduction of natalizumab biosimilar for patients with highly-active RRMS.
Methods: A budget impact model was developed, considering the INHS perspective and a 5-years time horizon. The number of patients treated with natalizumab was estimated based on historical natalizumab consumption data, disease prevalence rates and natalizumab market share. The budget impact population was divided into prevalent and incident patients. The model assumes that some patients in treatment with natalizumab originator will switch to natalizumab biosimilar and that some naïve patients will directly start treatment with natalizumab biosimilar. The ex-factory price of natalizumab originator (intravenous and subcutaneous) and biosimilar (intravenous) and the corresponding administration costs were included. All assumptions were validated by expert opinion.
Results: Eligible population was estimated at 7,552, 7,779, 8,090, 8,494 and 8,834 in years 1, 2, 3, 4 and 5 respectively. The introduction of natalizumab biosimilar, considering a progressive increase in market share from 9.6% (year 1) to 40.5% (year 5), would provide an overall savings (5-years time horizon) over € 47 million to the INHS. The scenario analysis highlights that the lower treatment cost of biosimilar natalizumab compared to originator natalizumab would offset the higher cost associated with intravenous versus subcutaneous administration.
Conclusion: Considering the results of this budget impact analysis, it is realistic to expect that the presence of biosimilar natalizumab will contribute to the sustainability of public pharmaceutical expenditure.
In vivo analgesic, anti-inflammatory, sedative, muscle relaxant activities, and docking studies of 3’,4’,7,8-tetrahydroxy-3-methoxyflavone isolated from Pistacia chinensis
Authors: Rauf Abdur , Rashid Umer , Akram Zuneera , Saeed Anees , Muhammad Naveed , Al Masoud Najla , Alomar Taghrid S. , Naz Saima , Iriti Marcello 
Published: June 2024

Background: Pistacia chinensis is extensively employed in traditional medicine. This study aimed to isolate and evaluate the therapeutic effects of 3’4’78-tetrahydroxy-3-methoxyflavone from P. chinensis crude extract.
Materials and Methods: The study utilized column chromatography for isolation. The plant extract and its isolated compound were assessed for in vivo analgesic (hot plate model), anti-inflammatory (carrageenan-induced paw edema), sedative (open field model), and muscle relaxing properties (inclined plane and traction test).
Results: In the thermal-induced analgesic model, a significant analgesic effect was observed for the extract (25, 50, and 100 mg/kg) and the isolated compound (2.5, 5, 10, and 15 mg/kg) at higher doses. The extract (100 mg/kg) significantly prolonged latency time (21.98 seconds) after 120 minutes of administration. The isolated compound elevated the latency time (20.03 seconds) after 30 minutes, remaining significant up to 120 minutes with a latency time of 24.11 seconds. The anti-inflammatory effect showed a reduction in inflammatory reactions by 50.23% (extract) and 67.09% (compound) after the fifth hour of treatment. Both samples demonstrated significant sedative effects, with the extract hindering movement by 54.11 lines crossed compared to the negative control (180.99 lines). The isolated compound reduced the number of lines crossed to 15.23±SEM compared to the negative control. Both samples were also significant muscle relaxants. Docking studies indicated that the compound’s therapeutic effect is due to inhibiting COX and nociceptive pathways.
Conclusion: The isolated compound from Pistacia chinensis exhibits significant analgesic, anti-inflammatory, sedative, and muscle relaxing properties, with potential therapeutic applications by inhibiting COX and nociceptive pathways.
Host specificity and zoonotic Enterocytozoon bieneusi genotypes in wild rodents from the Inner Mongolian Autonomous Region and Liaoning Province of China
Authors: Zhao Wei , Sun Lijie , Liu Li , Jiang Aiying , Xiao Qiang , Tan Feng 
Published: June 2024

IntroductionWild rodents can serve as reservoirs or carriers of E. bieneusi, thereby enabling parasite transmission to domestic animals and humans. This study aimed to investigate the prevalence of E. bieneusi in wild rodents from the Inner Mongolian Autonomous Region and Liaoning Province of China. Moreover, to evaluate the potential for zoonotic transmission at the genotype level, a genetic analysis of the isolates was performed.MethodsA total of 486 wild rodents were captured from two provinces in China. Polymerase chain reaction (PCR) was performed to amplify the vertebrate cytochrome b (cytb) gene in the fecal DNA of the rodents to detect their species. The genotype of E. bieneusi was determined via PCR amplification of the internal transcribed spacer (ITS) region of rDNA. The examination of genetic characteristics and zoonotic potential requires the application of similarity and phylogenetic analysis.ResultsThe infection rates of E. bieneusi in the four identified rodent species were 5.2% for Apodemus agrarius (n = 89), 4.5% for Cricetulus barabensis (n = 96), 11.3% for Mus musculus (n = 106), and 38.5% for Rattus norvegicus (n = 195). Infection was detected at an average rate of 17.4% among 486 rodents. Of the 11 identified genotypes, nine were known: SHR1 (detected in 32 samples), D (30 samples), EbpA (9 samples), PigEbITS7 (8 samples), HNR-IV (6 samples), Type IV (5 samples), HNR-VII (2 samples), HNH7 (1 sample), and HNPL-V (1 sample). Two novel genotypes were also discovered, NMR-I and NMR-II, each comprising one sample. The genotypes were classified into group 1 and group 13 via phylogenetic analysis.DiscussionBased on the initial report, E. bieneusi is highly prevalent and genetically diverse in wild rodents residing in the respective province and region. This indicates that these animals are crucial for the dissemination of E. bieneusi. Zoonotic E. bieneusi-carrying animals present a significant hazard to local inhabitants. Therefore, it is necessary to increase awareness regarding the dangers presented by these rodents and reduce their population to prevent environmental contamination.
Glycemic variability through the perspective of the glycemia risk index and time in range and their association with glycated hemoglobin A1c in pediatric patients on sensor-augmented pump therapy
Authors: Bukara-Radujkovic Gordana , Miljkovic Vesna 
Published: June 2024

IntroductionFrom the introduction of continuous glucose monitoring (CGM) in treatments of type 1 diabetes, particularly its integration with insulin pumps, there has been a quest for new parameters that describe optimal glycemic control. As of the consensus reached in 2019, the ambulatory glucose profile (AGP) has become the standard, with time in range (TIR) emerging as a fundamental parameter for metabolic control assessment. However, with technological advancements, new parameters, such as the glycemia risk index (GRI), have been introduced and clinically utilized. Therefore, exploring the relationships between traditional and novel parameters to understand metabolic control comprehensively is imperative.Materials and methodsThis study was conducted at the Pediatric Clinic of the University Hospital of the Republic of Srpska Banja Luka between January and July 2023. The participants were randomly selected, with the inclusion criteria specifying an age greater than eight years and a diabetes type 1 duration exceeding two years. All participants were required to use a sensor-augmented insulin pump for the next three months (90 days), irrespective of prior use, with the suspend-before-low option activated.ResultsOf the 35 participants, 30 completed the study, 14 (46.7%) of whom were male. The mean age of the subjects was 14.90 ± 2.88 years, and the mean duration of diabetes was 7.83 ± 4.76 years. Over the 90-day period, HbA1c increased to an average of 7.31%. The analysis revealed significant effects of TIR (β=-0.771) and GRI (β=0.651) on HbA1c. Furthermore, GRI and TIR strongly correlated (β=-0.953).Discussion and conclusionNew parameters generated from the ambulatory glucose profile (AGP) can help clinicians create a complete picture of a patient’s metabolic control in relation to HbA1c levels. Additionally, the GRI is a mathematically tailored parameter that incorporates all components of the ambulatory glucose profile and demonstrates strong correlations with laboratory-measured HbA1c and TIR. The GRI potentially can become a valuable statistical parameter for evaluating and managing patients in routine clinical practice.
LoadNet: enhancing energy storage system integration in power system operation using temporal convolutional and recurrent models with self-attention
Authors: Liu Minggang , Hu Xiaoxu 
Published: June 2024

Introduction: In the context of the evolving energy landscape, the efficient integration of energy storage systems (ESS) has become essential for optimizing power system operation and accommodating renewable energy sources.Methods: This study introduces LoadNet, an innovative approach that combines the fusion of Temporal Convolutional Network (TCN) and Gated Recurrent Unit (GRU) models, along with a self-attention mechanism, to address the challenges associated with ESS integration in power system operation. LoadNet aims to enhance the management and utilization of ESS by effectively capturing the complex temporal dependencies present in time-series data. The fusion architecture of TCN-GRU in LoadNet enables the modeling of both short-term and long-term dependencies, allowing for accurate representation of dynamic power system behaviors. Additionally, the incorporation of a self-attention mechanism enables LoadNet to focus on relevant information, facilitating informed decision-making for optimal ESS operation. To assess the efficacy of LoadNet, comprehensive experiments were conducted using real-world power system datasets.Results and Discussion: The results demonstrate that LoadNet significantly improves the efficiency and reliability of power system operation with ESS. By effectively managing the integration of ESS, LoadNet enhances grid stability and reliability, while promoting the seamless integration of renewable energy sources. This contributes to the development of a more sustainable and resilient power system. The proposed LoadNet model represents a significant advancement in power system management. Its ability to optimize power system operation by integrating ESS using the TCN-GRU fusion and self-attention mechanism holds great promise for future power system planning and operation. Ultimately, LoadNet can pave the way for a more sustainable and efficient power grid, supporting the transition to a clean and renewable energy future.
Comprehensive transcriptomic analysis identifies SLC25A4 as a key predictor of prognosis in osteosarcoma
Authors: Zhang Ying , Wang Yinghui , Zhang Wenyan , Feng Shaojie , Xing Yuanxin , Wang Tianjiao , Huang Nana , Li Ka , Zhang Aijun 
Published: June 2024

BackgroundOsteosarcoma (OS) is highly malignant and prone to local infiltration and distant metastasis. Due to the poor outcomes of OS patients, the study aimed to identify differentially expressed genes (DEGs) in OS and explore their role in the carcinogenesis and progression of OS.MethodsRNA sequencing was performed to identify DEGs in OS. The functions of the DEGs in OS were investigated using bioinformatics analysis, and DEG expression was verified using RT-qPCR and Western blotting. The role of SLC25A4 was evaluated using gene set enrichment analysis (GSEA) and then investigated using functional assays in OS cells.ResultsIn all, 8353 DEGs were screened. GO and KEGG enrichment analyses indicated these DEGs showed strong enrichment in the calcium signaling pathway and pathways in cancer. Moreover, the Kaplan-Meier survival analysis showed ten hub genes were related to the outcomes of OS patients. Both SLC25A4 transcript and protein expression were significantly reduced in OS, and GSEA suggested that SLC25A4 was associated with cell cycle, apoptosis and inflammation. SLC25A4-overexpressing OS cells exhibited suppressed proliferation, migration, invasion and enhanced apoptosis.ConclusionSLC25A4 was found to be significantly downregulated in OS patients, which was associated with poor prognosis. Modulation of SLC25A4 expression levels may be beneficial in OS treatment.
Integrative analysis of blood transcriptome profiles in small-cell lung cancer patients for identification of novel chemotherapy resistance-related biomarkers
Authors: Yang Fang , Fan Jinhua , Yang Runxiang , Cun Yupeng 
Published: June 2024

IntroductionChemoresistance constitutes a prevalent factor that significantly impacts thesurvival of patients undergoing treatment for smal-cell lung cancer (SCLC). Chemotherapy resistance in SCLC patients is generally classified as primary or acquired resistance, each governedby distinct mechanisms that remain inadequately researched.MethodsIn this study, we performed transcriptome screening of peripheral blood plasma obtainedfrom 17 patients before and after receiving combined etoposide and platinum treatment. We firs testimated pseudo-single-cell analysis using xCell and ESTIMATE and identified differentially expressed genes (DEGs), then performed network analysis to discover key hub genes involved in chemotherapy resistance.ResultsOur analysis showed a significant increase in class-switched memory B cell scores acrossboth chemotherapy resistance patterns, indicating their potential crucial role in mediatingresistance. Moreover, network analysis identifed PRICKLE3, TNFSFI0, ACSLl and EP300 as potential contributors to primary resistance, with SNWl, SENP2 and SMNDCl emerging assignificant factors in acquired resistance, providing valuable insights into chemotherapy resistancein SCLC.DiscussionThese findings offer valuable insights for understanding chemotherapy resistance and related gene signatures in SCLC, which could help further biological validation studies.