bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natural killer cell-mediated response to human cytomegalovirus-infected macrophages is modulated by their functional polarization
Authors: Romo Neus , Magri Giuliana , Muntasell Aura , Heredia Gemma , Baía Diogo , Angulo Ana , Guma Monica , López-Botet Miguel 
Published: July 2011

ABSTRACTMΦ comprise a heterogeneous population of cells, which contribute to host defense and maintenance of immune homeostasis. MΦ may be infected by human cytomegalovirus (HCMV), which has evolved different strategies to subvert the immune response. In the present study, we comparatively analyzed the natural killer (NK) cell response against HCMV (TB40E)-infected proinflammatory (M1) and antinflammatory (M2) MΦ, derived from autologous monocytes, cultured in the presence of GM-CSF and M-CSF, respectively. M1 MΦ were more resistant to infection and secreted IL-6, TNF-α, IFN-α, and IL-12; by contrast, in HCMV-infected M2 MΦ, proinflammatory cytokines, IL-10, and IFN-α production were limited and IL-12 was undetectable. NK cell degranulation was triggered by interaction with HCMV-infected M1 and M2 MΦ at 48 h postinfection. The response was partially inhibited by specific anti-NKp46, anti-DNAM-1, and anti-2B4 mAb, thus supporting a dominant role of these activating receptors. By contrast, only HCMV-infected M1 MΦ efficiently promoted NK cell-mediated IFN-γ secretion, an effect partially related to IL-12 production. These observations reveal differences in the NK cell response triggered by distinct, HCMV-infected, monocyte-derived cell types, which may be relevant in the immunopathology of this viral infection.
MR staging accuracy for endometrial cancer based on the new FIGO stage
Authors: Shin Kyung Eun , Park Byung Kwan , Kim Chan Kyo , Bae Duk Soo , Song Sang Yong , Kim Bohyun 
Published: July 2011

Background Magnetic resonance imaging (MRI) has been frequently used to determine a preoperative treatment plan for gynecologic cancers. However, the MR accuracy for staging an endometrial cancer is not satisfactory based on the old FIGO staging system. Purpose To evaluate MR accuracy for staging endometrial cancer using the new FIGO staging system. Material and Methods Between January 2005 and May 2009, 199 women underwent surgery due to endometrial cancer. In each patient, an endometrial cancer was staged using MR findings based on the old FIGO staging system and then repeated according to the new FIGO staging system for comparison. Histopathologic findings were used as a standard of reference. Results The accuracy of MRI in the staging of endometrial carcinoma stage I, II, III, and IV using the old FIGO staging system were 80% (159/199), 89% (178/199), 90% (179/199), and 99% (198/199), respectively, compared to 87% (174/199), 97% (193/199), 90% (179/199), and 99% (198/199), respectively, when using the new FIGO staging criteria. The overall MR accuracy of the old and new staging systems were 51% (101/199) and 81% (161/199), respectively. Conclusion MRI has become a more useful tool in the preoperative staging of endometrial cancers using the new FIGO staging system compared to the old one with increased accuracy.
Utility of time-resolved three-dimensional magnetic resonance digital subtraction angiography without contrast material for assessment of intracranial dural arterio-venous fistula
Authors: Hori Masaaki , Aoki Shigeki , Oishi Hidenori , Nakanishi Atsushi , Shimoji Keigo , Kamagata Koji , Houshito Haruyoshi , Kuwatsuru Ryohei , Arai Hajime 
Published: July 2011

Background Intracranial dural arteriovenous fistula (DAVF) is an arteriovenous shunting disease of the dura. Magnetic resonance angiography (MRA) is expected to be a safer alternative method in evaluation of DAVF, compared with invasive intra-arterial digital subtraction angiography (IADSA). Purpose To evaluate the diagnostic use of time-spatial labeling inversion pulse (Time-SLIP) three-dimensional (3D) magnetic resonance digital subtraction angiography (MRDSA) without contrast material in six patients with DAVF. Material and Methods Images for 3D time-of-flight MRA, which has been a valuable tool for the diagnosis of DAVF but provide little or less hemodynamic information, and Time-SLIP 3D MRDSA, were acquired for each patient. The presence, side, and grade of the disease were evaluated according to IADSA. Results In all patients, the presence and side of the DAVF were correctly identified by both 3D time-of-flight MRA and Time-SLIP 3D MRDSA. Cortical reflux present in a patient with a grade 2b DAVF was not detected by Time-SLIP 3D MRDSA, when compared with IADSA findings. Conclusion Time-SLIP 3D MRDSA provides hemodynamic information without contrast material and is a useful complementary tool for diagnosis of DAVF.
Do sonographic and cytological features predict malignancy in cytologically indeterminate thyroid nodules?
Authors: Dutta S , Thaha MA , Smith DM 
Published: July 2011

INTRODUCTION The current algorithm for managing patients with indeterminate (Thy3) thyroid cytology is a thyroid lobectomy followed by a completion thyroidectomy depending on histology. We investigated whether sonographic and or cytological features in addition to clinical characteristics would predict the potential for malignancy in a cohort of patients with thyroid nodules of indeterminate cytology. METHODS Perusing a clinical database of all patients undergoing ultrasonography guided fine needle aspiration (FNA) of thyroid nodules, we identified all Thy3 lesions. The demographic, ultrasonography and cytological details of benign and malignant groups were compared by t-test, chi-square test and, when appropriate, Fisher's exact test. Association between studied characteristics and malignancy was tested by binary logistic regression using single input. A p-value of <0.05 was considered significant. RESULTS During the retrospective study period of January 2003 to July 2010, a total of 1,019 patients underwent FNA, of which 69 (6.8%) were classed as Thy3. Of these, 59 underwent surgical treatment and the histological outcomes were grouped as benign (n=42, 71.2%) and malignant (n=17, 28.8%). These groups were analysed for the predictive variables. Age, sex and sonological characters were similar in the two groups (p>0.05). The two microcalcifications observed were both in the malignant group. Among all the variables assessed, only the absence of normal follicular cells was associated with malignant nodules (univariate analysis, p=0.034). CONCLUSIONS Malignancy was more common in Thy3 patients with an absence of normal follicular cells and such patients may therefore warrant a total thyroidectomy.
Use of Reporting Guidelines in Scientific Writing: PRISMA, CONSORT, STROBE, STARD and Other Resources
Authors: Tate Robyn L. , Douglas Jacinta 
Published: July 2011

AbstractIn this special article we describe a number of reporting guidelines endorsed by the CONSORT (Consolidated Standards of Reporting Trials) group for a range of research designs that commonly appear in scientific journals: systematic reviews, clinical trials with and without randomisation, observational studies, n-of-1 (or single-case experimental design) trials, and diagnostic studies. We also consider reporting guidelines for studies using qualitative methodology. In addition to reporting guidelines, we present method quality rating scales, which aim to measure risk of bias that threatens the internal validity of a study. Advantages of reporting guidelines and method quality rating scales for authors include the provision of a structure by which to improve the clarity and transparency of report writing; for reviewers and readers advantages include a method by which to critically appraise an article.Brain Impairmentendorses these reporting guidelines and applies them within the review process for submissions to the journal.
‘Cutting Edge’ Developments in Neuropsychological Rehabilitation and Possible Future Directions
Authors: Wilson Barbara A. 
Published: July 2011

AbstractThis article considers 10 of the most important developments in neuropsychological rehabilitation over the past 5 years. While several leaders in the field were contacted to discover what they considered to be the most important developments, the selection discussed here is the author's alone and is, therefore, a personal view. Included are: computational models; support for people with dementia; new assessment procedures; new treatment strategies for cognitive, emotional and psychosocial problems; new theoretical models to improve our understanding of the consequences of brain injury; and recognition of the need to find new ways to evaluate the efficacy of rehabilitation. The final section of the article considers possible future developments in rehabilitation, including stronger links with basic neuro-science; better use of imaging procedures; collaboration with pharmaceutical companies; better evaluation of our programs; and the need to educate researchers and practitioners as to the meaning of rehabilitation.
A Systematic Review of Acceptance and Commitment Therapy (ACT) for Managing Anxiety: Applicability for People With Acquired Brain Injury?
Authors: Soo Cheryl , Tate Robyn L. , Lane-Brown Amanda 
Published: July 2011

AbstractAcceptance and commitment therapy (ACT) is increasingly used in clinical practice to manage anxiety conditions. This psychotherapeutic approach focuses on the following: (1) acceptance of an individual's experience of the spectrum of psychological and emotional states, (2) choosing valued direction for the individual's life, and (3) commitment to action that leads the individual in the direction of those values. This article presents an empirical review of ACT for treatment of anxiety in two parts. In the first part we systematically review the literature for studies examining ACT for anxiety management in the general population with anxiety problems. In the second part, we discuss applicability of acceptance-based approaches for a health population in which these techniques may have applicability, that is, for people with acquired brain injury (ABI). Electronic searches for the review were conducted on PsycINFO and Medline. Inclusion criteria were as follows: (1) used an ACT intervention study, (2) the target of the intervention was an anxiety disorder or anxiety symptomatology, (3) the intervention used a randomised controlled trial (RCT) or single case experimental design (SCED) methodology, and (4) the paper was available in English. Studies were rated for methodological quality using standardised assessment procedures. Four RCTs provided support for ACT for obsessive compulsive disorder (OCD), maths anxiety, trichotillomania (TTM), and mixed anxiety and depression. Three SCED trials scoring in the high range on the scale of methodological quality revealed some support for ACT for managing TTM, skin picking, and OCD. Although no studies were identified that investigated ACT for managing anxiety in people with ABI, the review highlights issues for consideration when applying ACT in this population.
What Are the Characteristics of Traumatic Brain Injury in Older Adults?
Authors: Kinsella Glynda J. 
Published: July 2011

AbstractThe Australian community is ageing; over the next 40 years, our population over the age of 65 years will double to around 23%, and this considerable increase in older adults means an increasing number of people will be at risk of sustaining trauma through falls or road traffic accidents. In contrast to the increasingly well-documented outcome literature on younger adults, very few studies have focused on older adults. Instead of assuming that outcomes posttraumatic brain injury (post-TBI) will follow similar patterns as in younger samples, there are several reasons to investigate older age recovery separately, and these issues will be discussed by reviewing some of the primary characteristics of older adults who experience traumatic brain injury.
Student Prize-Winning Abstracts 2010
Authors: Hsieh Sharpley , Piguet Olivier , Hodges John R. 
Published: July 2011

AbstractIntroduction: Frontotemporal dementia (FTD) is a progressive neurode-generative brain disease characterised clinically by abnormalities in behaviour, cognition and language. Two subgroups, behavioural-variant FTD (bvFTD) and semantic dementia (SD), also show impaired emotion recognition particularly for negative emotions. This deficit has been demonstrated using visual stimuli such as facial expressions. Whether recognition of emotions conveyed through other modalities — for example, music — is also impaired has not been investigated. Methods: Patients with bvFTD, SD and Alzheimer's disease (AD), as well as healthy age-matched controls, labeled tunes according to the emotion conveyed (happy, sad, peaceful or scary). In addition, each tune was also rated along two orthogonal emotional dimensions: valence (pleasant/unpleasant) and arousal (stimulating/relaxing). Participants also undertook a facial emotion recognition test and other cognitive tests. Integrity of basic music detection (tone, tempo) was also examined. Results: Patient groups were matched for disease severity. Overall, patients did not differ from controls with regard to basic music processing or for the recognition of facial expressions. Ratings of valence and arousal were similar across groups. In contrast, SD patients were selectively impaired at recognising music conveying negative emotions (sad and scary). Patients with bvFTD did not differ from controls. Conclusion: Recognition of emotions in music appears to be selectively affected in some FTD subgroups more than others, a disturbance of emotion detection which appears to be modality specific. This finding suggests dissociation in the neural networks necessary for the processing of emotions depending on modality.
A Colorless and Bidirectional WDM-PON Doubling System Capacity
Authors: Cao Yanan , Gan Chaoqin 
Published: July 2011

Abstract
A colorless and bidirectional WDM-PON based on wavelength-locked RSOA technology is proposed. In this scheme, two service-ONUs in different wavelength bands are close to the user terminations. The broadband spectrum from either service-ONU is sliced by AWG located at the RN, and then the sliced lightwave is injected into the RSOA for upstream data. The system capacity can be doubled by adding some passive components at the RN. In simulation system, 2.5 Gb/s up/downstream data are transported successfully. In addition, transmission distance can be extended due to the less path loss of injected lightwave.
Ultracapacitors Based on Graphene/MWNT Composite Films
Authors: Wang Wei , Guo Shirui , Zhong Jiebin , Lin Jian , Ozkan Mihrimah , Ozkan Cengiz 
Published: July 2011

ABSTRACTUltracapacitors are promising candidate for alternative energy storage applications since they can store and deliver energy at relatively high rates. In this work, we integrated large area CVD graphene with multi-walled carbon nanotubes (MWNTs) to fabricate highly conductive, large surface-area composite thin films used as electrodes in ultracapacitors. Uniform, large area graphene layers were produced by CVD on copper foils and were chemically modified. Chemically shortened MWNTs, ranging in length of 200~500 nm, were deposited by dropping on graphene layers. Graphene/MWNT composite films with different thicknesses were obtained. The surface morphology was investigated by SEM. The results demonstrated relatively dense and homogeneous net nanostructure. The measurements of cyclic voltammetry, chronopotentiometry, and electrochemical impedance spectroscopy (EIS) are conducted to determine its performance of graphene/MWNT film structures.
Cardiovascular Toxicity Profiles of Vascular-Disrupting Agents
Authors: Subbiah Ishwaria M. , Lenihan Daniel J. , Tsimberidou Apostolia M. 
Published: July 2011

AbstractBackground.Vascular-disrupting agents (VDAs) represent a new class of chemotherapeutic agent that targets the existing vasculature in solid tumors. Preclinical and early-phase trials have demonstrated the promising therapeutic benefits of VDAs but have also uncovered a distinctive toxicity profile highlighted by cardiovascular events.Methods.We reviewed all preclinical and prospective phase I–III clinical trials published up to August 2010 in MEDLINE and the American Association of Cancer Research and American Society of Clinical Oncology meeting abstracts of small-molecule VDAs, including combretastatin A4 phosphate (CA4P), combretastatin A1 phosphate (CA1P), MPC-6827, ZD6126, AVE8062, and ASA404.Results.Phase I and II studies of CA1P, ASA404, MPC-6827, and CA4P all reported cardiovascular toxicities, with the most common cardiac events being National Cancer Institute Common Toxicity Criteria (version 3) grade 1–3 hypertension, tachyarrhythmias and bradyarrhythmias, atrial fibrillation, and myocardial infarction. Cardiac events were dose-limiting toxicities in phase I trials with VDA monotherapy and combination therapy.Conclusions.Early-phase trials of VDAs have revealed a cardiovascular toxicity profile similar to that of their vascular-targeting counterparts, the angiogenesis inhibitors. As these agents are added to the mainstream chemotherapeutic arsenal, careful identification of baseline cardiovascular risk factors would seem to be a prudent strategy. Close collaboration with cardiology colleagues for early indicators of serious cardiac adverse events will likely minimize toxicity while optimizing the therapeutic potential of VDAs and ultimately enhancing patient outcomes.
Concordance of Predictive Markers for EGFR Inhibitors in Primary Tumors and Metastases in Colorectal Cancer: A Review
Authors: Baas Jara M. , Krens Lisanne L. , Guchelaar Henk-Jan , Morreau Hans , Gelderblom Hans 
Published: July 2011

Abstract

Background.
Currently, only Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) mutational status is used as a decisional marker for epidermal growth factor receptor (EGFR) inhibitor therapy in colorectal cancer (CRC) patients. Concordance of KRAS status between primary tumors and metastases has always been considered to be close to perfect; however, cases of discordance have been reported. The actual rate of concordance of KRAS status remains unclear, as is the same for v-raf murine sarcoma viral oncogene homolog B1 (BRAF), phosphatidylinositol 3-kinase CA subunit (PIK3CA), and loss of phosphatase and tensin homologue deleted on chromosome ten (PTEN). Therefore, it is unknown whether it is necessary to perform mutational analysis on metastases instead of on (or in addition to) primary tumors.

Design.
A systematic literature search was conducted to collect all studies testing concordance of KRAS in CRC, and also of BRAF, PIK3CA, and loss of PTEN.

Results.
Twenty-one studies have reported concordance of KRAS, with an overall concordance rate of 93% (range, 76%–100%). Overall concordance rates of studies testing concordance of BRAF status and loss of PTEN were 98% and 68%, respectively. Three studies reported concordance of PIK3CA status (range, 89%–94%).

Conclusion.
Though discordance of KRAS status does occur, it is uncommon. When considering the downsides of testing metastatic tissue in all patients along with the low incidence of discordance, we conclude that that testing the primary tumor (or whatever tissue available) is sufficient for clinical decision making on EGFR inhibitor therapy.
Toxic Choices: The Theory and Impact of Smoking Bans
Authors: Irvine Ian J , Nguyen Hai V 
Published: July 2011

Abstract
This paper first proposes a theoretical model of smoker behaviour that serves as a vehicle to evaluate workplace smoking bans. It is a nicotine inventory management model where smoking during one phase of the day impacts utility in other phases. Smoking intensity choice forms part of the optimization. Calibrated model simulations suggest that, with the exception of heavy smokers, workplace bans have small impacts due to substitution possibilities. Quantile regression estimates support the theory. However, restrictions on smoking in the home are an order of greater importance, even when instrumented. The policy conclusion is that workplace ban effectiveness depends heavily upon private choices.
Nitrogen Inflation for Passenger Car and Light Truck Tires
Authors: Daws John 
Published: July 2011

Abstract
Nitrogen as an inflation gas for passenger car and light truck tires use is widely available commercially. Consumers are confronted with a bewildering selection of offerings, and suppliers tout the purity of their nitrogen generation systems and effectiveness of using the gas in place of air. This paper develops models for the initial tire nitrogen purity, the inflation pressure loss rate, and the evolution of the nitrogen gas purity in the tire as a function of the gas used to top off the tire over its life. A series of simulations using the basic model is developed for air and various purities of nitrogen initial inflation with monthly top-off using air or various purities of nitrogen. The initial inflation pressure loss rate is shown as a function of the tire’s initial nitrogen purity. This paper proposes the use of the total oxygen passing through the tire over its lifetime as a metric for evaluation of various inflation schemes. This metric is developed for several of the popular available nitrogen inflation purities using both air and nitrogen as a top-off gas.
Algebraic axiomatization of tense intuitionistic logic
Authors: Chajda Ivan 
Published: July 2011

Abstract
We introduce two unary operators G and H on a relatively pseudocomplemented lattice which form an algebraic axiomatization of the tense quantifiers “it is always going to be the case that” and “it has always been the case that”. Their axiomatization is an extended version for the classical logic and it is in accordance with these operators on many-valued Łukasiewicz logic. Finally, we get a general construction of these tense operators on complete relatively pseudocomplemented lattice which is a power lattice via the so-called frame.
Nondipole parameters of TDCS for electron impact ionization and drag current
Authors: Baltenkov Arkadiy , Manson Steven , Msezane Alfred 
Published: July 2011

Abstract
A comprehensive study is undertaken of angular distributions of electron knock-out from atomic targets by fast electrons with a small transfer of momentum. The general expressions for the parameters of the triple differential cross-section of impact ionization in the optical limit are derived. The calculated parameters are compared with those of the angular distribution of electrons ejected from an atom in the process of photoionization. In these processes, when the multipole transitions are involved, the one-to-one correspondence between the photoionization and impact ionization parameters disappears. The nondipole transitions lead to the backward/forward asymmetry of the angular distribution of ejected electrons that is absent in the dipole approximation for ionization by both fast electrons and photons. Using the He atom as an example, the character of the asymmetry for these two processes is qualitatively different and the backward/forward asymmetry results in macroscopic directed motion of secondary electrons accompanying the passing of a fast electron beam through gas or plasma. The general formulas for this drag current are derived and applied to gaseous He.