bluuebunny/crossref_metadata_2025_split huggingface dataset:
Logit modeling for classification of monocultivar olive oils from southwest Spain: A preliminary study
Authors: Sayago Ana , de la Luz Pizarro María , Beltrán María , Beltrán Rafael 
Published: October 2011

AbstractA characterization study of the main olive oil cultivars of southwest Spain (Picual, Arbequina, and Verdial) has been performed in order to establish logistic regression models. Several quality characteristics (free acidity, peroxide value, K232, K270, oxidative stability index) and chemical data (fatty acids, sterols, erythrodiol–uvaol composition) were measured. Logit regressions were used to evaluate the correlation of the parameters and to create models that allow saving costs on identifying oils as Arbequina, Picual, or Verdial type. Multiple logit regression models were developed: one for Arbequina, three models for Picual, and two models for Verdial cultivar, allowing in this way to minimize the cost for classifying oil samples.Practical application: The olive oil marketing is increasingly focused on the chemical differentiation and characterization of the product because the chemical composition of these virgin oils is responsible for their valuable sensory and nutritional properties. Here we present a characterization study (quality characteristics and chemical data) from the main olive oil cultivars of southwest Spain, Picual, Arbequina, and Verdial, as a first step for the traceability of these three types of monocultivar virgin olive oils. The results may be used as a training to create models for other olive oil cultivars.
Need and potential value of the Pig‐ain vivo mutation assay—A hesi perspective
Authors: Schuler Maik , Gollapudi B. Bhaskar , Thybaud Véronique , Kim James H. 
Published: October 2011

AbstractThe Health and Environmental Sciences Institute (HESI), a global branch of the International Life Sciences Institute (ILSI), initiated a project committee entitled “Relevance and Follow‐up of Positive Results from In Vitro Genetic Toxicity Testing (IVGT)” with the overall objective of improving the scientific basis for the interpretation of results from genetic toxicology testing. The IVGT committee has also recognized the need to develop follow‐up strategies for determining the relevance of in vitro test results to human health, and moving genetic toxicology testing from the sole purpose of hazard identification toward a more quantitative risk assessment approach. In this context, a group of experts evaluated the potential utility of the emerging in vivo mutational assessment model commonly known as the Pig‐a gene mutation assay to follow‐up positive in vitro genetic toxicology findings and to generate robust dose‐response data for quantitative assessment of the in vivo mutagenicity. The IVGT experts participating in this effort represented academia, industry, and government agencies from across the globe and addressed such issues as the optimal sample size and experimental design for generating robust dose‐response data. This expert group concluded that the emerging Pig‐a gene mutation assay holds great promise as an in vivo mutagenicity assay, either as a stand‐alone study or integrated into repeat‐dose toxicology studies, and therefore supports further validation of the model. Environ. Mol. Mutagen. 2011. © 2011 Wiley‐Liss, Inc.
Including of branch resistances in linear power transmission distribution factors for fast contingency analysis
Authors: Krsman Vladan D. , Sarić Andrija T. , Kovački Neven V. 
Published: October 2011

SUMMARYThis paper proposes an extension of the traditional DC‐based power flow model for obtaining the linear power transmission distribution factors (PTDFs) that includes the influence of the branch resistances. The proposed model is adopted for the fast contingency analysis, including cases of injection changes, branch outages and their combination. Proposed formulation saves the efficiency of the DC‐based model, such as linearity, fast matrix inversion by matrix inversion lemma for branch outages as well as fast block matrix inversion. This model is appropriate for subtransmission and transmission networks, where neglecting the branch resistances and other approximations introduced in DC‐based power model is not acceptable. The proposed generalized linear PTDF‐based model is successfully verified on the basis of the results for two examples: small (for educational purposes) test system and large‐scale (for industry applicability purposes) test system of Continental Europe Synchronous Area (ex‐UCTE) for characteristic contingencies (including the generation/load changes and branch outages). Copyright © 2011 John Wiley & Sons, Ltd.
Single end feeder arcing fault location using mutual inductance
Authors: Alamuti Mohsen Mohammadi , Nouri Hassan 
Published: October 2011

SUMMARYImpedance‐based fault location methods to date are able to locate only permanent and linear faults. Current fault location methods assume that arc resistance is constant to locate the fault. However, because of the variable nature of the arc resistance, arcing faults cannot be considered as a linear fault. Furthermore, the duration of intermittent and transitory faults is not necessarily enough for fundamental frequency‐based fault location methods. Therefore, available methods are not applicable for arcing fault location. In this article, a novel method is proposed for arcing fault location using time‐based formulation. The advantages of the proposed method over available methods are as follows: (i) fewer samples are necessary for the algorithm to calculate the location, (ii) it is capable of locating variable resistance faults, and (iii) it is independent of arcing fault type.The validity of the devised algorithm is studied within the power system computer aided design‐electromagnetic DC (PSCAD‐EMTDC) environment. Two different arc models have been simulated, and the produced data have been used for fault location algorithm. The results show a good accuracy for both arcing fault models. Copyright © 2011 John Wiley & Sons, Ltd.
MINIMUM SAVINGS REQUIREMENTS IN SHARED SAVINGS PROVIDER PAYMENT
Authors: Pope Gregory C. , Kautter John 
Published: October 2011

ABSTRACTPayer (insurer) sharing of savings is a way of motivating providers of medical services to reduce cost growth. A Medicare shared savings program is established for accountable care organizations in the 2010 Patient Protection and Affordable Care Act. However, savings created by providers cannot be distinguished from the normal (random) variation in medical claims costs, setting up a classic principal–agent problem. To lessen the likelihood of paying undeserved bonuses, payers may pay bonuses only if observed savings exceed minimum levels. We study the trade‐off between two types of errors in setting minimum savings requirements: paying bonuses when providers do not create savings and not paying bonuses when providers create savings. Copyright © 2011 John Wiley & Sons, Ltd.
Variations in glutathione‐S‐transferase genes influence risk of chronic myeloid leukemia
Authors: Özten Nur , Sunguroğlu Asuman , Bosland Maarten C. 
Published: October 2011

AbstractGlutathione S‐transferases (GSTs) are phase II enzymes that detoxify hazardous xenobiotics including carcinogens. Inter‐individual variations in GSTM1 and GSTT1 loci have been associated with several types of cancer, including leukemias. In this study, we investigated the possible association between GSTM1 and GSTT1 polymorphisms and susceptibility to chronic myeloid leukemia (CML) in a Turkish population. In a case‐control study, 106 CML patients and 190 healthy controls were evaluated for GSTM1 and GSTT1 polymorphisms. GSTM1 null (GSTM1‐) genotype frequencies in CML cases and controls were 45.3% and 42.6%, respectively. GSTT1 null (GSTT1‐) genotype frequencies were 44.3% and 18.4%, respectively. The frequency of the GSTT1‐ genotype among CML patients was significantly higher than in controls [odds ratio (OR) 3.53, 95% confidence interval (CI) 2.08‐6.00; P < 0.0001]. Individuals with the GSTM1‐ genotype did not have increased risk of CML [OR: 1.11; 95% CI: 0.69‐1.80; P = 0.714]. The combined GSTM1‐/ GSTT1‐ genotype was significantly associated with risk of CML compared to the GSTM1+/GSTT1+ genotype which was most frequent in both cases and controls [OR: 9.47; 95% CI: 3.61‐24.87]. Similar findings have only been obtained in Turkish and Indian populations but not elsewhere. The GSTM1+/GSTT1‐ genotype was associated with a 2.5‐fold increased risk compared with the GSTM1‐/GSTT1+ genotype, the second most frequent genotype (OR; 2.46; 95% CI: 1.17, 5.20), suggesting a complex interaction between GSTM1 and GSTT1. Our results indicate an association between the GSTT1‐ genotype, either alone or in combination with GSTM1‐ genotype, and risk of CML, suggesting a possible interaction between GSTM1 and GSTT1. These findings, which are possibly restricted to Turkey and India, warrant further research. Copyright © 2011 John Wiley & Sons, Ltd.
Antibacterial nanofiber materials activated by light
Authors: Jesenská Soňa , Plíštil Lukáš , Kubát Pavel , Lang Kamil , Brožová Libuše , Popelka Štěpán , Szatmáry Lórant , Mosinger Jiří 
Published: October 2011

AbstractElectrospun polymeric nanofiber materials doped with 5,10,15,20‐tetraphenylporphyrin (TPP) photosensitizer were prepared from four different polymers and were characterized with microscopic methods, steady‐state, and time‐resolved fluorescence and absorption spectroscopy. The polymers used included polyurethane Larithane™ (PUR), polystyrene (PS), polycaprolactone (PCL), and polyamide 6 (PA6). The antibacterial activity of all nanofiber materials against E. coli was activated by visible light and it was dependent on oxygen permeability/diffusion coefficients and the diameter of the polymeric nanofibers. This activity is based on oxidation ability of singlet oxygen O2(1Δg) that is generated upon irradiation. All tested nanofiber materials exhibited prolonged antibacterial properties, even in the dark after long‐duration irradiation. The post‐irradiation effect was explained by the photogeneration of H2O2, which provided the material with long‐lasting antibacterial properties. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2011.
In vitro evaluation of glass–glass ceramic thermoseed‐induced hyperthermia on human osteosarcoma cell line
Authors: Alcaide María , Ramírez‐Santillán Cecilia , Feito María José , de la Concepción Matesanz María , Ruiz‐Hernández Eduardo , Arcos Daniel , Vallet‐Regí María , Portolés María Teresa 
Published: October 2011

AbstractThe use of biomaterials as implantable thermoseeds under the action of an external magnetic field is a very interesting methodology to focus the heat into the target tumors as osteosarcoma. In this study, biocompatible and bioactive G15GC85 thermoseeds, tailored through the combination of sol–gel glasses (G) with a magnetic glass ceramic (GC), were used to induce hyperthermia on cultured human osteosarcoma cells after exposition to alternating magnetic field (MF, 100 kHz/200 Oe). G15GC85 magnetic glass–glass ceramic thermoseeds induced in vitro effective hyperthermia with drastic reduction in proliferation of human osteosarcoma Saos‐2 cells and high increase of apoptotic cells after two 40 min consecutive sessions of MF. Deep cell morphology alterations were observed after this hyperthermic treatment, and the proteomic analysis revealed modification of gamma actin molecular properties related to cytoskeleton alterations. These results indicate that G15GC85 thermoseeds allow to induce in vitro effective hyperthermia on human osteosarcoma cells. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2012.
Comparative study of myocytes from normal and mdx mice iPS cells
Authors: Chen Fei , Cao Jiqing , Liu Qiang , Qin Jie , Kong Jie , Wang Yanyun , Li Yaqin , Geng Jia , Li Qiuling , Yang Liqing , Xiang Andy Peng , Zhang Cheng 
Published: October 2011

AbstractRecently, induced pluripotent stem cells (iPS cells) have been derived from various techniques and show great potential for therapy of human diseases. Furthermore, the iPS technique can be used to provide cell models to explore pathological mechanisms of many human diseases in vitro, such as Duchenne muscular dystrophy (DMD), which is a severe recessive X‐linked form of muscular dystrophy without effective treatment. In this study, we try to determine whether there are different characteristics of myocytes from mdx iPS cells and C57BL/10 iPS cells. Our results showed that both of mdx and C57BL/10 cells could be induced into iPS cells in vitro, whereas colony‐forming ability of mdx iPS cells was much weaker than that of C57BL/10 iPS cells. Meanwhile, mdx iPS cells could be induced to differentiate into myocytes, whereas their differentiation efficiency was much lower than that of C57BL/10 iPS cells. And, the number of apoptotic cells in differentiated myocytes from mdx iPS cells was significantly higher than that from C57BL/10 iPS cells. More importantly, treatment of a pan‐caspase inhibitor (Z‐VAD) produced a significant decrease in apoptotic cells. This study might add some insight to the biology study of dystrophin gene. J. Cell. Biochem. 113: 678–684, 2012. © 2011 Wiley Periodicals, Inc.
Separation strategies for untargeted metabolomics
Authors: Patti Gary J. 
Published: October 2011

AbstractMetabolomics has rapidly become a profiling technique of choice for biomarker elucidation and molecular diagnostics in addition to studies focused on understanding disease pathogenesis. Key to the success of metabolomics in these areas has been the techniques to separate and analyze the chemically diverse group of compounds comprising the metabolome by using global and untargeted approaches. Untargeted metabolomic efforts have the goal of examining as many metabolites as possible simultaneously and most frequently use an LC/MS‐based approach. Here, the importance of LC in an untargeted metabolomic workflow is outlined and separation strategies for optimization are reviewed within the context of these criteria.
In Situ Spectroelectrochemical Study of Positively and Negatively Charged States in a Donor/Acceptor EDOT/Benzotriazole‐Based Polymer
Authors: Meana‐Esteban Beatriz , Balan Abidin , Baran Derya , Neugebauer Helmut , Toppare Levent , Sariciftci Niyazi Serdar 
Published: October 2011

AbstractPositively and negatively charged states in cPBEBT, which consists of EDOT/benzotriazole/EDOT as the building block, are studied using CV, in situ UV‐Vis, and FTIR‐ATR spectroscopy. The results show that cPBEBT is an ambipolar D‐A‐type polymer capable of conducting both holes and electrons. The injected positive and negative charges are distributed over the whole polymer backbone, which is proven by in situ FTIR‐ATR where spectral signatures associated with the benzotriazole unit are observed in both p‐ and n‐doped cPBEBT. HOMO and LUMO values obtained from CV and FTIR‐ATR experiments during oxidation and reduction are compared. cPBEBT is an example of the D‐A approach towards the improvement of the electronic properties of the resultant polymer.
Hydrogen‐Bonding‐Induced One‐Handed Helical Polynorbornenes Appended With Chiral Alaninegland
Authors: Kao Ming‐Jui , Chen Chih‐Hsien , Tsai Po‐Yu , Lim Tsong‐Shin , Lin Kin‐Chuan , Luh Tien‐Yau 
Published: October 2011

AbstractPolynorbornenes appended with anthracene and chiral alanine linkers are synthesized. Hydrogen bonding between the adjacent bisamidic linkers brings adjacent anthracene chromophores in a more suitable orientation for exciton coupling and renders one‐handed helical structures for these polymers. Excimer formation is observed from their emission spectra. Monoamidic linkers provide only one hydrogen bond, which would be less robust and result in much lower circular dichroic response.
Associations of lifestyle‐related factors, hsa‐miR‐149 and hsa‐miR‐605 gene polymorphisms with gastrointestinal cancer risk
Authors: MW Zhang , MJ Jin , YX Yu , SC Zhang , B Liu , X Jiang , YF Pan , QL Li , XY Ma , K Chen 
Published: October 2011

AbstractTo explore the associations of SNPs within hsa‐miR‐605 (rs2043556) and hsa‐miR‐149 (rs2292832) and lifestyle‐related factors with gastrointestinal cancer, a case–control study including 762 cases and 757 controls was conducted. Marginally significant associations were found both for hsa‐miR‐149 rs2292832 with gastric cancer risk (TC + CC vs. TT, OR = 0.68, 95% CI: 0.44–1.04) and for hsa‐miR‐605 rs2043556 with colorectal cancer risk (AG + GG vs. AA, OR = 0.70, 95% CI: 0.48–1.02) in males. Tea drinking showed a protective effect on gastric cancer risk (OR = 0.28, 95% CI: 0.13–0.60), while smoke inhalation increased the risk of gastric cancer (OR = 1.94, 95% CI: 1.08–3.47). Irritability was found to be a risk factor for both colorectal cancer (OR = 1.61, 95% CI: 1.02–2.53) and gastric cancer (OR = 1.96, 95% CI: 1.17–3.29). Among those that engaged in smoke inhalation, miR‐149 CT/CC and miR‐605 AG/GG genotype carriers had increased susceptibilities to colorectal cancer (OR = 1.90, 95% CI: 1.11–3.25) and gastric cancer (OR = 1.87, 95% CI: 1.03–3.42), respectively. Among the tea drinkers, there exists a marginally protective effect of miR‐605 AG/GG genotypes on colorectal cancer incidence (OR = 0.71, 95% CI: 0.47–1.06) and a significantly protective effect of miR‐149 CT/CC on gastric cancer incidence (OR = 0.47, 95% CI: 0.29–0.77). The SNPs of rs2292832 and rs2043556 might be able to modify the susceptibility to male gastric and colorectal cancers, respectively. Tea drinking is a protective factor, while smoke inhalation is a risk factor for gastric cancer, and they might have the potential to modify the associations between miR‐149 and miR‐605 polymorphisms with gastrointestinal cancer risk. In addition, irritability was shown to be a risk factor for both gastric and colorectal cancers. © 2011 Wiley Periodicals, Inc.
ATR controls the p21WAF1/Cip1 protein up‐regulation and apoptosis in response to low UV fluences
Authors: Al‐Khalaf Huda H. , Hendrayani Siti‐Faujiah , Aboussekhra Abdelilah 
Published: October 2011

AbstractThe universal cyclin‐dependent kinase inhibitor p21WAF1/Cip1 promotes cell cycle arrest and inhibits apoptosis in response to UV‐induced DNA damage. Since the protein kinase ATR plays a major role in the cellular response to these carcinogenic lesions, we investigated the possible role of ATR in the modulation of p21WAF1/Cip1 expression in response to UVC radiation. We have shown that p21WAF1/Cip1 is up‐regulated in human fibroblast and epithelial cells, but only in response to low UV fluences and low passage cells. Importantly, this up‐regulation is ATR‐dependent. In fact, in ATR‐deficient or caffeine‐treated cells UV light rather down‐regulated the p21WAF1/Cip1 protein through SKP2‐dependent ubiquitination and degradation via the proteasomal pathway. Furthermore, we present evidence that ATR inhibits apoptosis in response to low fluences of UV light, through inhibiting the cleavage of caspase 3 and PARP as well as the repression of the proapoptotic proteins BAX and BAK. Interestingly, ATR is also required for the stability of the p21WAF1/Cip1 protein in absence of genotoxic stress. Together, these results indicate that during the cellular response to low UVC fluences the ATR protein kinase up‐regulates p21WAF1/Cip1 and inhibits apoptosis. © 2011 Wiley Periodicals, Inc.
A long‐term assessment of precipitation forecast skill using the Fractions Skill Score
Authors: Mittermaier Marion , Roberts Nigel , Thompson Simon A. 
Published: October 2011

AbstractThe Fractions Skill Score (FSS) is a spatial verification metric routinely computed in the operational verification suite. It enables the comparison of forecasts of different resolutions against a common spatial truth (radar rainfall analyses) in such a way that high‐resolution forecasts are not penalized for representativeness errors that arise from the ‘double penalty’ problem. Officially Met Office model precipitation forecast accuracy is monitored using the Equitable Threat Score (ETS) at gauge locations. These precipitation scores form part of a basket of measures assessing six surface parameters known as the UK index, which forms the basis for making decisions regarding model upgrades (especially over the UK). It is used to monitor the impact of continuous model improvements. This framework and the methodology underlying it, is less appropriate for high‐resolution forecasts for reasons as described above. For precipitation forecasts in particular, a new framework for long‐term monitoring is necessary and the FSS provides such a potential framework.This paper provides an objective critique of FSS results to date. It has been shown that the ‘convection‐permitting’ (4 km) Unified Model (MetUM) forecasts are better than the 12 km MetUM (significant at the 5% level). The scale at which the models have sufficient practical skill is typically 10 km better for the high‐resolution forecasts, and are better at forecasting afternoon convection exceeding 4 mm (6 h)−1. The use of frequency (percentile) thresholds is recommended because of the implicit bias removal this approach provides, as any rain in a forecast period is treated as ‘the event of interest’. © 2011 British Crown Copyright, the Met Office. Published by John Wiley & Sons Ltd.
DAS28 and Rheumatoid Arthritis: The Need for Standardization
Authors: Porter Duncan , Gadsby Kate , Thompson Paul , White Jo , McClinton Catherine , Oliver Sue 
Published: October 2011

AbstractDisease Activity Score in 28 Joints (DAS28) scoring in rheumatoid arthritis (RA) is now recommended as a basis for clinical decisions about treatment initiation and alteration. The British Society of Rheumatology suggests that most RA patients should have a DAS28 assessment at every clinic visit, to monitor disease activity and the impact of therapy. Establishing an accurate baseline assessment of DAS28, with regular re‐evaluation, is considered crucial, so that progress towards a defined target of remission (or low disease activity) can be measured. The Treat‐to‐Target initiative, launched in March 2010, is now impacting on clinical practice throughout the UK and Europe. One of its key recommendations is that patients should be regularly monitored using validated composite measures of disease activity that include joint assessments. DAS28 is recommended as one of the most useful of these methods but, although it is becoming more widely adopted and training is ongoing, supported by materials produced by the European League Against Rheumatism (EULAR), the variability inherent in the four components of DAS28 means that standardization of practice methods is now an important issue. This short report details some of the pitfalls that can occur when applying DAS28 in clinical practice and suggests some workable solutions to enable departments to set up their own standard operating procedure Copyright © 2011 John Wiley & Sons, Ltd.
Lebensmittelassoziierten Bakterientoxinen auf der Spur
Authors: Aust Olivier 
Published: October 2011

AbstractWenn Krankheiten ausbrechen, die von Bakterien auf Lebensmitteln ausgehen, stellt sich für Lebens mittelüberwachungs‐ und Gesundheitsbehörden die Frage nach der Herkunft und damit nach der Nachweismethode. Das gilt für epidemieartige Ausbrüche wie die Ehec‐Infektionen durch kontaminiertes Sprossengemüse in diesem Frühsommer ebenso wie für Einzelfälle etwa von Botulismus durch verdorbene Lebensmittelkonserven.