bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of heel lifts for lower limb musculoskeletal conditions: A systematic review
Authors: Bourke Jaryd , Munteanu Shannon , Merza Eman , Garofolini Alessandro , Taylor Simon , Malliaras Peter 
Published: June 2024

AbstractIntroductionThe objective of this systematic review is to determine the benefits and harms of heel lifts to any comparator for lower limb musculoskeletal conditions.MethodsOvid MEDLINE, Ovid AMED, Ovid EMCARE, CINAHL Plus and SPORTDiscus were searched from inception to the end of May 2024. Randomised, quasi‐randomised or non‐randomised trials comparing heel lifts to any other intervention or no‐treatment were eligible for inclusion. Data was extracted for the outcomes of pain, disability/function, participation, participant rating of overall condition, quality of life, composite measures and adverse events. Two authors independently assessed risk of bias and certainty of evidence using the GRADE approach at the primary time point 12 weeks (or next closest).ResultsEight trials (n = 903), investigating mid‐portion Achilles tendinopathy, calcaneal apophysitis and plantar heel pain were included. Heel lifts were compared to exercise, ultrasound, cryotherapy orthotics, stretching, footwear, activity modification, felt pads and analgesic medication. No outcome was at low risk of bias and few effects (2 out of 47) were clinically important. Low‐certainty evidence (1 trial, n = 199) indicates improved pain relief (55.7 points [95% CI: 50.3–61.1], on a 100 mm visual analogue scale) with custom orthotics compared to heel lifts at 12 weeks for calcaneal apophysitis. Very low‐certainty evidence (1 trial, n = 62) indicates improved pain and function with heel lifts over indomethacin (35.5 points [95% CI: 21.1–49.9], Foot Function Index) at 12 months for plantar heel pain.ConclusionsFew trials have assessed the benefits and harms of heel lifts for lower limb musculoskeletal conditions. Only two outcomes out of 47 showed clinically meaningful between group differences. However, due to very low to low certainty evidence we are unable to be confident in the results and the true effect may be substantially different.RegistrationPROSPERO registration number CRD42022309644.
The effect of jaw suspension on cartilage strength in elasmobranchs
Authors: Wilga Cheryl , Ferry Lara , Dumont Elizabeth 
Published: June 2024

AbstractThe jaws and their supporting cartilages are tessellated in elasmobranchs and exhibit an abrupt increase in stiffness under compression. The major jaw‐supporting cartilage, the hyomandibula, varies widely by shape and size and the extent of the load‐bearing role is hypothesized to be inversely related to the number of craniopalatine articulations. Here, we test this hypothesis by evaluating the strength of the hyomandibular cartilage under compression in 13 species that represent all four jaw suspension systems in elasmobranchs (amphistyly, orbitostyly, hyostyly, and euhyostyly). The strength of the hyomandibular cartilages was measured directly using a material testing machine under compressive load, and indirectly by measuring morphological variables putatively associated with strength. The first measure of strength is force to yield (Fy), which was the peak force (N) exerted on the hyomandibula before plastic deformation. The second measure was compressive yield strength (σy, also called yield stress), which is calculated as peak force (N) before plastic deformation/cross‐sectional area (mm2) of the specimen. Our results show that the load‐bearing role of the hyomandibular cartilage, as measured by yield strength, is inversely related to the number of craniopalatine articulations, as predicted. Force to yield was lower for euhyostylic jaw suspensions and similar for the others. We also found that mineralization is associated with greater yield strength, while the second moment of area is associated with greater force to yield.
Beyond Google Scholar, Scopus, and Web of Science: An evaluation of the backward and forward citation coverage of 59 databases' citation indices
Authors: Gusenbauer Michael 
Published: June 2024

AbstractCitation indices providing information on backward citation (BWC) and forward citation (FWC) links are essential for literature discovery, bibliographic analysis, and knowledge synthesis, especially when language barriers impede document identification. However, the suitability of citation indices varies. While some have been analyzed, the majority, whether new or established, lack comprehensive evaluation. Therefore, this study evaluates the citation coverage of the citation indices of 59 databases, encompassing the widely used Google Scholar, Scopus, and Web of Science alongside many others never previously analyzed, such as the emerging Lens, Scite, Dimensions, and OpenAlex or the subject‐specific PubMed and JSTOR. Through a comprehensive analysis using 259 journal articles from across disciplines, this research aims to guide scholars in selecting indices with broader document coverage and more accurate and comprehensive backward and forward citation links. Key findings highlight Google Scholar, ResearchGate, Semantic Scholar, and Lens as leading options for FWC searching, with Lens providing superior download capabilities. For BWC searching, the Web of Science Core Collection can be recommended over Scopus for accuracy. BWC information from publisher databases such as IEEE Xplore or ScienceDirect was generally found to be the most accurate, yet only available for a limited number of articles. The findings will help scholars conducting systematic reviews, meta‐analyses, and bibliometric analyses to select the most suitable databases for citation searching.
Progress of research on aroma absorption mechanism and aroma fixation pathway of jasmine green tea
Authors: Wang Yueguang , Huang Zifeng , Zhou Taoyi , Li Charlie , Sun Yilan , Pang Jie 
Published: June 2024

AbstractThis overview summarizes the latest research progress on the aroma absorption mechanism and aroma fixation pathway of jasmine green tea, and discusses in depth the aroma absorption mechanism of green tea, the aroma release mechanism of jasmine flowers, as well as the absorption and fixation mechanism of the aroma components of jasmine green tea in the process of scenting, to provide a theoretical basis for the improvement of the quality of jasmine green tea and the innovation of processing technology. It was found that the aroma absorption mechanism of jasmine green tea is mainly associated with both physical and chemical adsorption, aroma release in jasmine involves the phenylpropanoid/benzoin biosynthetic pathway, β‐glycosidase enzymes interpreting putative glycosidic groups, and heat shock proteins (HSPs) as molecular chaperones to prevent stress damage in postharvest flowers due to high temperatures and to promote the release of aroma components, and so forth. The preparation of aroma‐protein nano‐complexes, heat stress microcapsules, and the spraying of polymeric substances – β‐cyclodextrin are three examples of aroma‐fixing pathways. This overview also summarizes the problems and future development trends of the current research and proposes the method of loading benzyl acetate, the main aroma component of jasmine, through konjac glucomannan (KGM)‐based gel to solve the problem of volatile aroma and difficult‐to‐fix aroma, which provides a reference for the sustainable development of the jasmine green tea industry. © 2024 Society of Chemical Industry.
Orange passion fruit (Passiflora caerulea L.) as a new raw material for acetic fermentation: evaluation of organic acids and phenolic profile, in vitro digestion, and biological activities
Authors: da Silva Monteiro Wanderley Bruna Rafaela , de Lima Natália Duarte , Deolindo Carolina Turnes Pasini , Ansiliero Rafaela , Kempka Aniela Pinto , Moroni Liziane Schittler , Louredo Francisca Jamila Correia , Gonzaga Luciano Valdemiro , Costa Ana Carolina Oliveira , Amboni Renata Dias De Mello Castanho , de Sena Aquino Ana Carolina Moura , Fritzen‐Freire Carlise Beddin 
Published: June 2024

AbstractBACKGROUNDThis study evaluated for the first time the potential of orange passion fruit as a base for alcoholic and acetic fermentations, with a view to assessing its profile of organic acids and polyphenols, in vitro digestion, and biological activities.RESULTSIn terms of aliphatic organic acids, malic acid was the majority in the wine (3.19 g L−1), while in the vinegar, it was acetic acid (46.84 g L−1). 3,4‐Dihydroxybenzoic acid (3,4‐DHB) was the major phenolic compound in the wine and vinegar samples (3443.93 and 2980.00 μg L−1, respectively). After the in vitro gastrointestinal simulation stage, the wine showed high bioaccessibility for the compounds sinipaldehyde (82.97%) and 2,4‐dihydroxybenzoic acid (2,4‐DHBA, 81.27%), while the vinegar exhibited high bioaccessibility for sinipaldehyde (89.39%). Through multivariate analysis, it was observed that 3,4‐DHB was highly concentrated in the different digested fractions obtained from the wine. In contrast, in the vinegar, the stability of isorahmenetin and Quercetin 3‐o‐rhamnoside was observed during the in vitro digestion simulation. Lastly, the vinegar stood out for its inhibition rates of α‐amylase (23.93%), α‐glucoside (18.34%), and angiotensin‐converting enzyme (10.92%). In addition, the vinegar had an inhibitory effect on the pathogenic microorganisms Salmonella enteritidis, Escherichia coli, and Listeria monocytogenes.CONCLUSIONOrange passion fruit has proved to be a promising raw material for the development of fermented beverages. Therefore, this study provides an unprecedented perspective on the use and valorization of orange passion fruit, contributing significantly to the advancement of knowledge about fermented products and the associated nutritional and functional possibilities. © 2024 Society of Chemical Industry.
Endoscopic Distance and its Impact on Quantified Age‐related Vocal Fold Atrophy Measures
Authors: Aboueisha Mohamed A. , Sauder Cara , Jaleel Zaroug , Fatahallah Yasmine , Adcock Kelson , Al‐awadi Hamzah , Jafari Aria , Bhatt Neel K. 
Published: June 2024

IntroductionThe bowing index (BI) and normalized glottal gap area (NGGA) are used to quantify vocal fold morphology in ARVA; however, the influence of the distance between the flexible laryngoscope lens and the target area is not known. The goal is to test whether the endoscopic distance impacts vocal fold morphology measurements in patients with ARVA during flexible video laryngostroboscopy (VLS).MethodPatients with ARVA who underwent VLS were included. Images were classified into near (close to the petiole of the epiglottis) and far (below nasopharynx, with tongue base and entire epiglottis visible) conditions. BI was calculated using a mobile application, and NGGA was measured using ImageJ.ResultsThis study included 23 patients; the mean age was 77 ± 7 years. Mean BI measured at the near distance was higher than far distances with a mean difference of 1.94 (95% CI: 0.92–2.96, p = 0.001). NGGA showed difference with changed distance −0.24 (95% CI: −0.48 to 0.01, p < 0.05).When stratifying patients into two groups based on median BI measurement, there was a statistically significant difference between near and far conditions, with increased BI in the near condition for patients above the median (p < 0.05), but no difference between the near and far condition for patients with BI below the median.ConclusionThe BI and NGGA were impacted by the endoscopic distance during flexible VLS. BI was significantly higher in the near condition compared with the far condition. The difference in BI between the near and far conditions was more pronounced when the vocal fold bowing was greater. These findings call for heightened awareness of measurement discrepancies secondary to the endoscopic distance during flexible laryngostroboscopy.Level of Evidence2 Laryngoscope, 134:4649–4655, 2024
Thermal and Mechanical Properties of Bio‐Based Polyamide 56/6 Filled with Talc
Authors: Zhang Xiaoqi , Yang Haoyu , Liu Yiming , Liu Jilin , Zhou Jie , Liu Wentao 
Published: June 2024

AbstractPolyamide composites with varying filler concentrations are prepared using the hot melt extrusion method, employing polyamide 56/6 (PA56/6) and modified talc as fillers. Initially, the thermal characteristics of PA56/6 composites (PA56/6‐talc) are examined through thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), encompassing parameters such as melting temperature, crystallinity, and decomposition temperature. The hydrophilicity and barrier properties of PA56/6‐talc are assessed using an optical contact angle meter, a water vapor transmission rate tester, and an oxygen transmission rate tester. Furthermore, the mechanical properties of PA56/6‐talc are also scrutinized. The results indicate that PA56/6 exhibits superior hydrophobic, barrier, and mechanical properties, thereby demonstrating its immense potential in garment fabrics and packaging materials.
Spider minor ampullate silk protein nanoparticles: an effective protein delivery system capable of enhancing systemic immune responses
Authors: Yu Hairui , Chen Gefei , Li Linchao , Wei Guoqiang , Li Yanan , Xiong Sidong , Qi Xingmei 
Published: June 2024

AbstractSpider silk proteins (spidroins) are particularly attractive due to their excellent biocompatibility. Spider can produce up to seven different types of spidroins, each with unique properties and functions. Spider minor ampullate silk protein (MiSp) might be particularly interesting for biomedical applications, as the constituent silk is mechanically strong and does not super‐contract in water, attributed to its amino acid composition. In this study, we evaluate the potential of recombinant nanoparticles derived from Araneus ventricosus MiSp as a protein delivery carrier. The MiSp‐based nanoparticles were able to serve as an effective delivery system, achieving nearly 100% efficiency in loading the model protein lysozyme, and displayed a sustained release profile at physiological pH. These nanoparticles could significantly improve the delivery efficacy of the model proteins through different administration routes. Furthermore, nanoparticles loaded with model protein antigen lysozyme after subcutaneous or intramuscular administration could enhance antigen‐specific immune responses in mouse models, through a mechanism involving antigen‐depot effects at the injection site, long‐term antigen persistence, and efficient uptake by dendritic cells as well as internalization by lymph nodes. These findings highlight the transnational potential of MiSp‐based nanoparticle system for protein drug and vaccine delivery.
Natural killer cells in cancer immunotherapy
Authors: Wang DanRu , Dou LingYun , Sui LiHao , Xue Yiquan , Xu Sheng 
Published: June 2024

AbstractNatural killer (NK) cells, as innate lymphocytes, possess cytotoxic capabilities and engage target cells through a repertoire of activating and inhibitory receptors. Particularly, natural killer group 2, member D (NKG2D) receptor on NK cells recognizes stress‐induced ligands—the MHC class I chain‐related molecules A and B (MICA/B) presented on tumor cells and is key to trigger the cytolytic response of NK cells. However, tumors have developed sophisticated strategies to evade NK cell surveillance, which lead to failure of tumor immunotherapy. In this paper, we summarized these immune escaping strategies, including the downregulation of ligands for activating receptors, upregulation of ligands for inhibitory receptors, secretion of immunosuppressive compounds, and the development of apoptosis resistance. Then, we focus on recent advancements in NK cell immune therapies, which include engaging activating NK cell receptors, upregulating NKG2D ligand MICA/B expression, blocking inhibitory NK cell receptors, adoptive NK cell therapy, chimeric antigen receptor (CAR)‐engineered NK cells (CAR‐NK), and NKG2D CAR‐T cells, especially several vaccines targeting MICA/B. This review will inspire the research in NK cell biology in tumor and provide significant hope for improving cancer treatment outcomes by harnessing the potent cytotoxic activity of NK cells.
Responsive Versus Continuous Deep Brain Stimulation for Speech in Essential Tremor: A Pilot Study
Authors: Cernera Stephanie , Long Sarah , Kelberman Madison , Hegland Karen W. , Hicks Julie , Smith‐Hublou May , Taylor Bryn , Mou Yuhan , de Hemptinne Coralie , Johnson Kara A. , Cagle Jackson N. , Moore Kathryn , Foote Kelly D. , Okun Michael S. , Gunduz Aysegul 
Published: June 2024

AbstractBackgroundResponsive deep brain stimulation (rDBS) uses physiological signals to deliver stimulation when needed. rDBS is hypothesized to reduce stimulation‐induced speech effects associated with continuous DBS (cDBS) in patients with essential tremor (ET).ObjectiveTo determine if rDBS reduces cDBS speech‐related side effects while maintaining tremor suppression.MethodsEight ET participants with thalamic DBS underwent unilateral rDBS. Both speech evaluations and tremor severity were assessed across three conditions (DBS OFF, cDBS ON, and rDBS ON). Speech was analyzed using intelligibility ratings. Tremor severity was scored using the Fahn‐Tolosa‐Marin Tremor Rating Scale (TRS).ResultsDuring unilateral cDBS, participants experienced reduced speech intelligibility (P = 0.025) compared to DBS OFF. rDBS was not associated with a deterioration of intelligibility. Both rDBS (P = 0.026) and cDBS (P = 0.038) improved the contralateral TRS score compared to DBS OFF.ConclusionsrDBS maintained speech intelligibility without loss of tremor suppression. A larger prospective chronic study of rDBS in ET is justified. © 2024 International Parkinson and Movement Disorder Society.
Sciatic nerve fascicle differentiation on high‐resolution ultrasound with histological verification: An ex vivo study
Authors: Snoj Žiga , Pušnik Luka , Cvetko Erika , Burica Matičič Urša , Jengojan Suren Armeni , Omejec Gregor 
Published: June 2024

AbstractIntroduction/AimsThe development of high‐resolution ultrasound (HRUS) has enabled the depiction of peripheral nerve microanatomy in vivo. This study compared HRUS fascicle differentiation to the structural depiction in histological cross‐sections (HCS).MethodsA human cadaveric sciatic nerve was marked with 10 surgical sutures, and HRUS image acquisition was performed with a 22‐MHz probe. The nerve was excised and cut into five segments for HCS preparation. Selected HCS were cross‐referenced to HRUS, with sutures to improve orientation. Sciatic nerve and fascicle contouring were performed to assess nerve and fascicular cross‐sectional area (CSA), fascicle count, and interfascicular distances. Three groups were defined based on HRUS fascicle differentiation in comparison to HCS, namely single fascicle (SF), fascicular cluster (FC), and no depiction (ND) group.ResultsOn cross‐referenced HRUS to HCS images, 58% of fascicles were differentiated. On HRUS, significantly larger fascicle CSA and smaller fascicle count were observed compared with HCS. Group analysis showed that 41% of fascicles were defined as SF, 47% as FC, and 12% as ND. The mean fascicle CSA in the ND group was 0.05 mm2. Compared with the SF, the FC had significantly larger fascicle CSA (1.2 ± 0.7 vs. 0.6 ± 0.4 mm2; p < .001) and shorter interfascicular distances (0.1 ± 0.04 vs. 0.5 ± 0.3 μm; p < .001).DiscussionWhile HRUS can depict fascicular anatomy, only half of the fascicles visualized on HRUS directly correspond to single fascicles observed on HCS. The amount of interfascicular epineurium appears to influence the ability of HRUS to differentiate individual fascicles.
Firm decisions and government subsidies in a supply chain with consumer surplus consideration
Authors: Xiao Yongbo , Zhang Xiuyi , Wu Xiaole 
Published: June 2024

AbstractThis paper considers a supply chain that consists of a manufacturer and a retailer, who concern their respective profits as well as consumer welfare. Each firm's objective is modelled as a weighted sum of its profit and consumer surplus, with the weight on consumer surplus representing the concern level of the firm. We first examine a push supply chain where the manufacturer determines the wholesale price and the retailer determines the order quantity. We derive the optimal decisions and investigate the impact of the firms' consumer surplus consideration on the interactive decisions of the supply chain members and the overall performance of the supply chain. We show that a higher level of retailer's consumer concern does not necessarily lead to higher consumer surplus because her concern on consumers may be exploited by the manufacturer to improve his objective; and the manufacturer's concern on consumers may not benefit the retailer in terms of her profit, especially when the manufacturer's concern level is relatively low. Nevertheless, compared to the for‐profit supply chain, concern on consumer surplus could be beneficial to both firms' profits as well as consumer surplus, inducing a “win‐win‐win” situation under certain conditions. Furthermore, as a social planner, the government seeks to optimize social welfare by adopting subsidy policies, and we examine two types of intervention policies, that is, subsidizing firms and subsidizing consumers. We show that when subsidizing firms, government's quantity‐based subsidy is always more cost‐effective than sales‐based subsidy. As the firms' concern levels become higher or the demand uncertainty becomes lower, subsidizing consumers can achieve higher social welfare than subsidizing firms. Moreover, we examine the impact of the government's budget constraint and concern level on consumer surplus, and extend the analysis to a pull supply chain to show the robustness of the major findings.
Simultaneous improvement of tensile strength and toughness of polylactic acid by incorporating a biodegradable core‐shell nanofiller with double polymer layers
Authors: Gao Yuan , Peng Zhiyuan , Deng Tianbo , Zhang Ling , Li Chunzhong 
Published: June 2024

AbstractWhile blending with flexible polymers has been a commonly employed strategy to enhance the toughness of polylactic acid (PLA), it's still a great challenge to avoid the sacrifice of tensile strength at the same time. In this work, we demonstrate a promising route to simultaneously improve the strength and toughness of PLA by compounding PLA with poly(ε‐caprolactone) (PCL) and PLA grafted multi‐walled carbon nanotubes core‐shell nanofiller (MWNT‐PCLPLA) via a two‐step ring‐opening polymerization and have analyzed the strengthening and toughening mechanism through molecular dynamics simulation. The double polymer layers of MWNT‐PCLPLA effectively improve the interfacial interaction between MWNTs and the matrix, in which the outer PLA layer has the same molecular structure with the matrix and facilitates stress transfer, while the flexible PCL layer can absorb energy through self‐deformation and induce local plastic deformation of the matrix. When the content of MWNTs was only 1 wt%, the strength and elongation at break of PLA/MWNT‐PCLPLA nanocomposites were increased by 47.92% and 690.11% compared to neat PLA. Furthermore, the toughness of nanocomposites reached 11.93 MJ/m3, which is about 16 times that of neat PLA. This novel core‐shell nanofiller with double polymer layers is expected to be further applied in other polymer systems.Highlights
A core‐shell nanofiller with double polymer layers was synthesized.
Improved dispersion and interfacial compatibility of nanofillers in matrix.
The crystallization ability of PLA was improved by functionalized MWNTs.
Simultaneously improved strength and toughness of PLA/MWNT‐PCLPLA nanocomposite.