bluuebunny/crossref_metadata_2025_split huggingface dataset:
Watching the fetal brain at ‘rest’
Authors: Schöpf V. , Kasprian G. , Brugger P.C. , Prayer D. 
Published: October 2011

AbstractFunctional magnetic resonance imaging (fMRI) has allowed insights into the spatiotemporal distribution of human brain networks. According to the neurophysiological property of the fetal brain to generate spontaneous activity, we aimed to determine the feasibility of investigating the maturation of intrinsic networks, beginning at gestational week 20 in healthy human fetuses by combining resting‐state fMRI and an analytical approach, independent component analysis (ICA).In this study, functional images of 16 fetuses with morphologically normal brain development, from 20 to 36 gestational weeks of age, were acquired on a 1.5 T unit (Philips Medical Systems, Best, The Netherlands) using single‐shot, gradient‐recalled echo‐planar imaging. After preprocessing (motion correction, brain extraction), images were analyzed using single‐subject ICA.We visualized a bilateral occipital network and medial and lateral prefrontal activity pattern that involved the future Brodmann areas 9–11. Furthermore, there was one either predominantly right (3/7 cases) or left (4/7 cases) hemispheric lateralized network that involved the superior temporal cortical regions (Brodmann areas 22 and 39). Frequency oscillations were in the range of 0.01–0.06 Hz for all networks.This study shows that resting‐state networks (RSNs) are shaped and are detectable in utero. Further investigations of resting‐state measurements in the fetus may therefore allow developmental brain activity monitoring and may provide insights into early brain function.
Assessment of knowledge and stigmatizing attitudes related to human papillomavirus among Hong Kong Chinese healthcare providers
Authors: Kwan Tracy T.C. , Lo Sue S.T. , Tam Kar‐Fai , Chan Karen K.L. , Ngan Hextan Y.S. 
Published: October 2011

AbstractObjectiveTo assess knowledge and stigmatizing attitudes related to human papillomavirus (HPV) and HPV testing among Chinese healthcare providers in Hong Kong.MethodsBetween May and September 2010, an anonymous self‐administered questionnaire was sent to 247 doctors, nurses, and smear‐taking trainees providing cervical screening in Hong Kong.ResultsIn total, 137 questionnaires were returned. Most participants had basic knowledge about HPV infection and HPV vaccination. Only about 33% knew that high‐risk HPV does not cause genital warts, infection is most common among young women, or infected individuals might not have any identifiable sexual risk factors. Regarding HPV testing, 6 of 7 knowledge items were answered incorrectly by many participants (≥ 50%), highlighting a lack of understanding of the indications for HPV testing and the implications of a positive result. About 30% of participants agreed that individuals with HPV infection were sexually easy, responsible for their infection, or had more than 1 sexual partner. More knowledge about HPV infection predicted less stigmatizing attitudes.ConclusionContinued education on HPV and HPV testing is needed for frontline healthcare providers of screening in Hong Kong. The stigmatizing attitudes toward HPV‐infected individuals warrant further exploration of the impact of HPV infection on patient care and interventions.
Regional variation in histopathology‐specific incidence of invasive cervical cancer among Peruvian women
Authors: Pierce Campbell Christine M. , Curado Maria P. , Harlow Siobán D. , Soliman Amr S. 
Published: October 2011

AbstractObjectiveTo evaluate patterns of cervical cancer incidence in Peru by examining variation in 2 common histopathologic types, squamous cell carcinoma (SCC) and adenocarcinoma (ADC), and analyzing trends over time.MethodsData on the incidence of invasive cervical cancer between 1984 and 2006 were obtained from 3 population‐based cancer registries in Peru: Lima, Trujillo, and Arequipa. For each registry, data quality assessment was performed, crude and age‐specific incidence was calculated, and time trends were analyzed.ResultsOverall and SCC incidence varied across registries but incidence of ADC did not. Overall and SCC incidence showed significant declines in Trujillo (P < 0.05) and modest declines in Lima (P > 0.05) over time. ADC incidence showed marginally significant increases among women aged 15–29 years in Trujillo (P = 0.10) and modest increases among young women in Lima (P > 0.05).ConclusionPopulation‐based cancer registries were an efficient source of data for evaluating the incidence of cervical cancer once data quality had been established. Geographic and temporal variations in cervical cancer burden were documented in Peru. The trends suggest that cervical ADC is increasing among young women in urban Peru, particularly in Trujillo. We recommend supplementing current Papanicolaou test screening with complementary methods of cervical cancer control, including human papillomavirus (HPV) vaccination and HPV DNA testing.
Biomarkers, Genetics, and Risk Factors for Concussion
Authors: Finnoff Jonathan T. , Jelsing Elena J. , Smith Jay 
Published: October 2011

AbstractIt is estimated that between 1.6 and 3.8 million concussions occur annually in the United States. Although frequently regarded as benign, concussions can lead to multiple different adverse outcomes, including prolonged postconcussive symptoms, chronic traumatic encephalopathy, cognitive impairment, early onset dementia, movement disorders, psychiatric disorders, motor neuron disease, and even death. Therefore it is important to identify individuals with concussion to provide appropriate medical care and minimize adverse outcomes. Furthermore, it is important to identify individuals who are predisposed to sustaining a concussion or to having an adverse outcome after concussion. This article will discuss the current research on serum biomarkers for concussion, genetic influence on concussion, risk factors associated with concussion predisposition and poor outcome, and practical suggestions for the application of this information in clinical practice.
Concussions and the Military: Issues Specific to Service Members
Authors: Rigg John L. , Mooney Scott R. 
Published: October 2011

AbstractSince October 2001, more than 1.6 million American military service members have deployed to Iraq and Afghanistan in the Global War on Terrorism. It is estimated that between 5% and 35% of them have sustained a concussion, also called mild traumatic brain injury (mTBI), during their deployment. Up to 80% of the concussions experienced in theater are secondary to blast exposures. The unique circumstances and consequences of sustaining a concussion in combat demands a unique understanding and treatment plan. The current literature was reviewed and revealed a paucity of pathophysiological explanations on the nature of the injury and informed treatment plans. However, through observation and experience, a theoretical but scientifically plausible model for why and how blast injuries experienced in combat give rise to the symptoms that affect day‐to‐day function of service members who have been concussed has been developed. We also are able to offer treatment strategies based on our evaluation of the current literature and experience to help palliate postconcussive symptoms. The purpose of this review is to elucidate common physical, cognitive, emotional, and situational challenges, and possible solutions for this special population of patients who will be transitioning into the civilian sector and interfacing with health professionals. There is a need for further investigation and testing of these strategies.
Long‐term Consequences of Repetitive Brain Trauma: Chronic Traumatic Encephalopathy
Authors: Stern Robert A. , Riley David O. , Daneshvar Daniel H. , Nowinski Christopher J. , Cantu Robert C. , McKee Ann C. 
Published: October 2011

AbstractChronic traumatic encephalopathy (CTE) has been linked to participation in contact sports such as boxing and American football. CTE results in a progressive decline of memory and cognition, as well as depression, suicidal behavior, poor impulse control, aggressiveness, parkinsonism, and, eventually, dementia. In some individuals, it is associated with motor neuron disease, referred to as chronic traumatic encephalomyelopathy, which appears clinically similar to amyotrophic lateral sclerosis. Results of neuropathologic research has shown that CTE may be more common in former contact sports athletes than previously believed. It is believed that repetitive brain trauma, with or possibly without symptomatic concussion, is responsible for neurodegenerative changes highlighted by accumulations of hyperphosphorylated tau and TDP‐43 proteins. Given the millions of youth, high school, collegiate, and professional athletes participating in contact sports that involve repetitive brain trauma, as well as military personnel exposed to repeated brain trauma from blast and other injuries in the military, CTE represents an important public health issue. Focused and intensive study of the risk factors and in vivo diagnosis of CTE will potentially allow for methods to prevent and treat these diseases. Research also will provide policy makers with the scientific knowledge to make appropriate guidelines regarding the prevention and treatment of brain trauma in all levels of athletic involvement as well as the military theater.
Transition to turbulence through steep global-modes cascade in an open rotating cavity
Authors: Viaud Bertrand , Serre Eric , Chomaz Jean-Marc 
Published: October 2011

AbstractThe transition to turbulence in a rotating boundary layer is analysed via direct numerical simulation (DNS) in an annular cavity made of two parallel corotating discs of finite radial extent, with a forced inflow at the hub and free outflow at the rim. In a former numerical investigation (Viaud, Serre & Chomaz J. Fluid Mech., vol. 598, 2008, pp. 451–464) realized in a sectorial cavity of azimuthal extent $2\lrm{\pi} / 68$, we have established the existence of a primary bifurcation to nonlinear global mode with angular phase velocity and radial envelope coherent with the so-called elephant mode theory. The former study has demonstrated the subcritical nature of this primary bifurcation with a base flow that keeps being linearly stable for all Reynolds numbers studied. The present work investigates the stability of this elephant mode by extending the cavity both in the radial and azimuthal direction. When the Reynolds number based on the forced throughflow is increased above a threshold value for the existence of the nonlinear global mode, a large-amplitude impulsive perturbation gives rise to a self-sustained saturated wave with characteristics identical to the 68-fold global elephant mode obtained in the smaller cavity. This saturated wave is itself globally unstable and a second front appears in the lee of the primary where small-scale instability develops. These secondary instabilities are identical for the $2\lrm{\pi} / 68$ and the $2\lrm{\pi} / 4$ long sectorial cavities, indicating that transition involves a Floquet mode of zero azimuthal wavenumber. This secondary instability leads to a very disorganized state, defining the transition to turbulence. The observed transition to turbulence linked to the secondary instability of a global mode confirms, for the first time on a real flow, the possibility of a direct transition to turbulence through an elephant mode cascade, a scenario that was up to now only observed on the Ginzburg–Landau model.
Comparing the genetic structure of codling mothCydia pomonella(L.) from Greece and France: long distance gene-flow in a sedentary pest species
Authors: Voudouris C.Ch. , Franck P. , Olivares J. , Sauphanor B. , Mamuris Z. , Tsitsipis J.A. , Margaritopoulos J.T. 
Published: October 2011

AbstractCodling mothCydia pomonellaL. (Lepidoptera: Tortricidae) is the most important insect pest of apple production in Europe. Despite the economic importance of this pest, there is not information about the genetic structure of its population in Greece and the patterns of gene-flow which might affect the success of control programs. In this study, we analysed nine samples from apple, pear and walnut from various regions of mainland Greece using 11 microsatellite loci. Six samples from the aforementioned hosts from southern France were also examined for comparison. Bayesian clustering and genetic distance analyses separated the codling moth samples in two genetic clusters. The first cluster consisted mainly of the individuals from Greece, and the second of those from France, although admixture and miss-classified individuals were also observed. The low genetic differentiation among samples within each country was also revealed byFSTstatistics (0.009 among Greek samples and 0.0150 among French samples compared to 0.050 global value among all samples and 0.032 the mean of the pair-wise values between the two countries). TheseFSTvalues suggest little structuring at large geographical scales in agreement with previous published studies. The host species and local factors (climatic conditions, topography, pest control programs) did not affect the genetic structure of codling moth populations within each country. The results are discussed in relation to human-made activities that promote gene-flow even at large geographic distances. Possible factors for the genetic differentiation between the two genetic clusters are also discussed.
Exploring the pattern and neural correlates of neuropsychological impairment in late-life depression
Authors: Sexton C. E. , McDermott L. , Kalu U. G. , Herrmann L. L. , Bradley K. M. , Allan C. L. , Le Masurier M. , Mackay C. E. , Ebmeier K. P. 
Published: October 2011

BackgroundNeuropsychological impairment is a key feature of late-life depression, with deficits observed across multiple domains. However, it is unclear whether deficits in multiple domains represent relatively independent processes with specific neural correlates or whether they can be explained by cognitive deficits in executive function or processing speed.MethodWe examined group differences across five domains (episodic memory; executive function; language skills; processing speed; visuospatial skills) in a sample of 36 depressed participants and 25 control participants, all aged ⩾60 years. The influence of executive function and processing speed deficits on other neuropsychological domains was also investigated. Magnetic resonance imaging correlates of executive function, processing speed and episodic memory were explored in the late-life depression group.ResultsRelative to controls, the late-life depression group performed significantly worse in the domains of executive function, processing speed, episodic memory and language skills. Impairments in executive function or processing speed were sufficient to explain differences in episodic memory and language skills. Executive function was correlated with anisotropy of the anterior thalamic radiation and uncinate fasciculus; processing speed was correlated with anisotropy of genu of the corpus callosum. Episodic memory was correlated with anisotropy of the anterior thalamic radiation, the genu and body of the corpus callosum and the fornix.ConclusionsExecutive function and processing speed appear to represent important cognitive deficits in late-life depression, which contribute to deficits in other domains, and are related to reductions in anisotropy in frontal tracts.
Political Theory beyond the Rhetoric–Reason Divide: Hobbes, Semantic Indeterminacy, and Political Order
Authors: Skinner Daniel 
Published: October 2011

AbstractThis article engages the longstanding debate over Hobbes's use of rhetoric, with the aim of rethinking both the political logic ofLeviathanand the way contemporary theorists approach rhetoric in relation to reason. Rhetoric was a particularly acute problem for Thomas Hobbes, whose pursuit of a stable political order may appear to require the absence of rhetoric and the presence of a purely rational order. This appearance is misleading, and it is suggested therefore that political theorists rethink how they understand rhetoric to grasp more fully Hobbes's understanding of political order. The common view that Hobbes resolves the problem of semantic indeterminacy must be questioned. Hobbes in effect understands that stable meaning structures are impossible to attain, even under Leviathan. This reworking suggests the need for refining our understanding of Hobbes, who envisions political order not by privileging reason over rhetoric, but by moving beyond engagements with language altogether.
Rights and the Heart: Emotions and Rights Claims in the Political Theory of Edmund Burke
Authors: Hall Lauren 
Published: October 2011

AbstractEdmund Burke's emphasis on emotional phenomena is often seen as a rejection of reason. The relationship between reason and the emotions in Burke's work is paralleled by the relationships between the individual and society and between rights and duties. Emotions support duties because they bind us to social life and a particular social location. Burke filters rights claims through our emotional attachment to specific circumstances, thus creating social rights of man in contrast to the individualistic, abstract rights of men of the social contract theorists. Prejudice is presented as an example of a Burkean filter for rights that moderates rights claims by binding individuals to society. Thus, Burke sees reason and emotion as interconnected phenomena that support the balancing of the claims of both individual and the community.
Is there linguistic life after high school? Longitudinal changes in the bilingual repertoire in metropolitan Barcelona
Authors: Woolard Kathryn 
Published: October 2011

AbstractDo linguistic identities formed in high school endure after adolescence? Do age-related linguistic differences represent community trends over historical time, or are they age-graded practices that change over biographical time? Catalan advocates worry that perceived Castilian dominance in adolescents' peer relations and media consumption forecasts the community's sociolinguistic future. To investigate the possibility of change in bilingual repertoires after adolescence, participants in a 1987 ethnographic study of high school students in metropolitan Barcelona were reinterviewed after twenty years. The reinterviews of L1 Castilian-speakers showed increased mastery and use of Catalan even among those who had been functionally monolingual and most resistant to Catalan in high school. Higher education, the workplace, romance, cosmopolitan travel, and parenthood were triggers of such postadolescent change in the linguistic repertoire. Informants produce a common narrative attributing linguistic transformations to maturational processes that reduce the shame and intolerance of difference that inhibit adolescent second language use. (Bilingualism, second language acquisition, longitudinal research, language and identity, adolescence, Catalan, Catalonia)*
High zooplankton diversity in the extreme environments of the McMurdo Dry Valley lakes, Antarctica
Authors: Hansson Lars-Anders , Hylander Samuel , Dartnall Herbert J.G. , Lidström Sven , Svensson Jan-Erik 
Published: October 2011

AbstractThe McMurdo Dry Valley lakes of Antarctica constitute some of the harshest and most isolated freshwater environments on Earth which might be expected to limit the biogeographical expansion of many organisms. Despite this, we found that the biodiversity of rotifer zooplankton is the highest ever recorded on the Antarctic mainland. We identified in total nine rotifer taxa, of which six are new to the Antarctic continent, in Lake Hoare, and also the first sub-adult crustacean copepod belonging to the genusBoeckella. A possible explanation for the high biodiversity is that many of the recorded species have arrived in the region in relatively recent times and then established invasive populations, suggesting that their distribution pattern was previously limited only by biogeographical borders. Interestingly, we show that the cosmopolitan rotifer taxa identified are relatively abundant, suggesting that they have established viable populations. Hence, our study suggests that the biogeographical maps have to be redrawn for several species.
Autumn migration of soaring birds through the Gebel El Zeit Important Bird Area (IBA), Egypt, threatened by wind farm projects
Authors: HILGERLOH GUDRUN , MICHALIK ANDREAS , RADDATZ BERND 
Published: October 2011

SummarySystematic bird observations were performed during autumn 2006 in the migration bottleneck area of Zeit Bay, Egypt (27.73°N, 33.51°E), situated on the coast of the Gulf of Suez, opposite southern Sinai. Owing to the strong northerly winds in that area, considerable pressure exists to construct wind farms. A total of 145,432 soaring birds, including 134,599 storks and 9,376 raptors over a period of 453.6 hours were observed between 20 August and 29 October by two teams working daily in two shifts. White Stork Ciconia ciconia and European Honey Buzzard Pernis apivorus were the most numerous species (91.4% and 5.7% respectively) of all soaring birds observed. As both species migrate early, relatively few birds were recorded passing through in October. A total of 57,179 soaring birds were observed within a range of 2.5 km from the observers, and of these 32,248 were flying at heights up to 200 m. Few individuals of the rapidly declining breeding populations of Egyptian Vulture Neophron percnotperus (‘Endangered’) and Lesser Kestrel Falco naumanni (‘Vulnerable’) passed (8 and 33 respectively). Pallid Harriers Circus macrourus (‘Near Threatened’) however, were more numerous (100) than at other migration sites along the East African-West Asian Flyway (Israel, southern tip of Sinai, Suez and Bab-el-Mandeb). Western Marsh Harrier Circus aeruginosus and Montagu’s Harrier Circus pygargus were also more numerous than at these sites. Some other large migrant species, observed at Suez, Bab el-Mandeb or in Israel, were seen only in small numbers or not at all at Zeit Bay in autumn. Among them, the Steppe Eagle Aquila nipalensis being the best known example of loop migration, entering Africa at Suez and Bab el-Mandeb, is for this reason not expected in autumn at Zeit Bay, while in spring it is a regular migrant. The number of Black Storks Ciconia nigra observed accounted for 4.8% of the flyway population, that of White Storks for 33.3%, Great White Pelicans Pelecanus onocrotalus for a further 3.5% and European Honey Buzzards for 0.8%. The extrapolation of the number of birds passing through the study area during the migration season, suggests that it was used by 92% of the White Stork, 12% of the Black Stork, 5% of the Great White Pelican, 4% of the European Honey Buzzard and 2% of the Pallid Harrier flyway populations in autumn 2006.
A Method for Quick, Low-Cost Automated Confluency Measurements
Authors: Topman Gil , Sharabani-Yosef Orna , Gefen Amit 
Published: October 2011

AbstractA culture's confluency is a fundamental measure in the field of biology, and routine quantification of confluence in cell culture protocols, biological assays and tissue engineering work is important. However, current techniques for obtaining confluency are either subjective, destructive, not simple enough, or time-consuming. We developed an image processing method for automated confluency measurement from a single microscope image without any chemical staining. To demonstrate utility we monitored the confluency of three cell types: NIH3T3 fibroblasts, C2C12 myoblasts, and 3T3L1 pre-adipocytes for 5 days, twice a day. The captured micrographs had different and uneven illumination, the cell types varied in cell-to-background contrast, and the confluency ranged between 10% and 100%. Despite these variable conditions, our method was shown to be practical, economic, and easy to implement, providing quantitative confluency measurements over time in each culture case. The method is hence suitable for routine automatic determination of confluency to standardize handling of cells, achieve reproducibility across trials, and improve accuracy in experimental outcome measures.