bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inverse kinematics solution and control method of 6-degree-of-freedom manipulator based on deep reinforcement learning
Authors: Zhao Chengyi , Wei Yimin , Xiao Junfeng , Sun Yong , Zhang Dongxing , Guo Qiuquan , Yang Jun 
Published: May 2024

AbstractThe advent of Industry 4.0 has significantly promoted the field of intelligent manufacturing, which is facilitated by the development of new technologies are emerging. Robot technology and robot intelligence methods have rapidly developed and been widely applied. Manipulators are widely used in industry, and their control is a crucial research topic. The inverse kinematics solution of manipulators is an important part of manipulator control, which calculates the joint angles required for the end effector to reach a desired position and posture. Traditional inverse kinematics solution algorithms often face the problem of insufficient generalization, and iterative methods have challenges such as large computation and long solution time. This paper proposes a reinforcement learning-based inverse kinematics solution algorithm, called the MAPPO-IK algorithm. The algorithm trains the manipulator agent using the MAPPO algorithm and calculates the difference between the end effector state of the manipulator and the target posture in real-time by designing a reward mechanism, while considering Gaussian distance and cosine distance. Through experimental comparative analysis, the feasibility, computational efficiency, and superiority of this reinforcement learning algorithm are verified. Compared with traditional inverse kinematics solution algorithms, this method has good generalization and supports real-time computation, and the obtained result is a unique solution. Reinforcement learning algorithms have better adaptability to complex environments and can handle different sudden situations in different environments. This algorithm also has the advantages of path planning, intelligent obstacle avoidance, and other advantages in dynamically processing complex environmental scenes.
Disseminated intravascular coagulation is associated with poor prognosis in patients with COVID-19
Authors: Gando Satoshi , Akiyama Takayuki 
Published: May 2024

AbstractThis study aimed to investigate the incidence and significance of disseminated intravascular coagulation (DIC) in coronavirus disease 2019 (COVID-19). A multicenter cohort study was conducted using large-scale COVID-19 registry data. The patients were classified into DIC and non-DIC groups based on the diagnosis on admission (day 1) and on any of the days 1, 4, 8, and 15. In total, 23,054 patients were divided into DIC (n = 264) and non-DIC (n = 22,790) groups on admission. Thereafter, 1654 patients were divided into 181 patients with DIC and 1473 non-DIC patients based on the DIC diagnosis on any of the days from 1 to 15. DIC incidence was 1.1% on admission, increasing to 10.9% by day 15. DIC diagnosis on admission had moderate predictive performance for developing multiple organ dysfunction syndrome (MODS) on day 4 and in-hospital death and was independently associated with MODS and in-hospital death. DIC diagnosis on any of the days from 1 to 15, especially days 8 and 15, was associated with lower survival probability than those without DIC and showed significant association with in-hospital death. In conclusion, despite its low incidence, DIC, particularly late-onset DIC, plays a significant role in the pathogenesis of poor prognosis in patients with COVID-19.
Determination of cinnamaldehyde, thymol and eugenol in essential oils by LC–MS/MS and antibacterial activity of them against bacteria
Authors: Li Zhi , Li Yan , Cheng Wenbo 
Published: May 2024

AbstractPlant essential oils contain many secondary metabolites, some of which can effectively inhibit the growth of pathogenic microorganisms, so it is a very promising antibacterial agent. In this study, a qualitative and quantitative method based on high performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) was developed for the simultaneous determination of three bioactive substances, cinnamaldehyde (CNM), thymol (THY), and eugenol (EUG), in the essential oils of plants. Necessary tests for linearity, limit of quantification, recovery, carryover contamination and precision of the method were carried out. Then, the antibacterial activity of 3 bioactive compounds against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) was evaluated by minimal inhibitory concentration and the synergistic antimicrobial effect. The results indicated that CNM, THY and EUG had good antibacterial activity. According to the results of fractional inhibitory concentration index (FICI), it is considered that CNM + THY and CNM + THY + EUG has obvious synergistic inhibitory effect on E. coli, and CNM + THY and CNM + EUG has obvious synergistic inhibitory effect on S. aureus. Finally, we analyzed the effect of the bioactive compounds on trace elements in bacteria and found significant changes in magnesium, calcium, copper and iron.
Capillary wave tweezer
Authors: Orme Bethany , Torun Hamdi , Unthank Matthew , Fu Yong-Qing , Ford Bethan , Agrawal Prashant 
Published: May 2024

AbstractPrecise control of microparticle movement is crucial in high throughput processing for various applications in scalable manufacturing, such as particle monolayer assembly and 3D bio-printing. Current techniques using acoustic, electrical and optical methods offer precise manipulation advantages, but their scalability is restricted due to issues such as, high input powers and complex fabrication and operation processes. In this work, we introduce the concept of capillary wave tweezers, where mm-scale capillary wave fields are dynamically manipulated to control the position of microparticles in a liquid volume. Capillary waves are generated in an open liquid volume using low frequency vibrations (in the range of 10–100 Hz) to trap particles underneath the nodes of the capillary waves. By shifting the displacement nodes of the waves, the trapped particles are precisely displaced. Using analytical and numerical models, we identify conditions under which a stable control over particle motion is achieved. By showcasing the ability to dynamically control the movement of microparticles, our concept offers a simple and high throughput method to manipulate particles in open systems.
Multiscale knowledge distillation with attention based fusion for robust human activity recognition
Authors: Yuan Zhaohui , Yang Zhengzhe , Ning Hao , Tang Xiangyang 
Published: May 2024

AbstractKnowledge distillation is an effective approach for training robust multi-modal machine learning models when synchronous multimodal data are unavailable. However, traditional knowledge distillation techniques have limitations in comprehensively transferring knowledge across modalities and models. This paper proposes a multiscale knowledge distillation framework to address these limitations. Specifically, we introduce a multiscale semantic graph mapping (SGM) loss function to enable more comprehensive knowledge transfer between teacher and student networks at multiple feature scales. We also design a fusion and tuning (FT) module to fully utilize correlations within and between different data types of the same modality when training teacher networks. Furthermore, we adopt transformer-based backbones to improve feature learning compared to traditional convolutional neural networks. We apply the proposed techniques to multimodal human activity recognition and compared with the baseline method, it improved by 2.31% and 0.29% on the MMAct and UTD-MHAD datasets. Ablation studies validate the necessity of each component.
Estimation of patient-reported outcome measures based on features of knee joint muscle co-activation in advanced knee osteoarthritis
Authors: Hussain Iqram , Kim Sung Eun , Kwon Chiheon , Hoon Seo Kyung , Kim Hee Chan , Ku Yunseo , Ro Du Hyun 
Published: May 2024

AbstractElectromyography (EMG) is considered a potential predictive tool for the severity of knee osteoarthritis (OA) symptoms and functional outcomes. Patient-reported outcome measures (PROMs), such as the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and visual analog scale (VAS), are used to determine the severity of knee OA. We aim to investigate muscle activation and co-contraction patterns through EMG from the lower extremity muscles of patients with advanced knee OA patients and evaluate the effectiveness of an interpretable machine-learning model to estimate the severity of knee OA according to the WOMAC (pain, stiffness, and physical function) and VAS using EMG gait features. To explore neuromuscular gait patterns with knee OA severity, EMG from rectus femoris, medial hamstring, tibialis anterior, and gastrocnemius muscles were recorded from 84 patients diagnosed with advanced knee OA during ground walking. Muscle activation patterns and co-activation indices were calculated over the gait cycle for pairs of medial and lateral muscles. We utilized machine-learning regression models to estimate the severity of knee OA symptoms according to the PROMs using muscle activity and co-contraction features. Additionally, we utilized the Shapley Additive Explanations (SHAP) to interpret the contribution of the EMG features to the regression model for estimation of knee OA severity according to WOMAC and VAS. Muscle activity and co-contraction patterns varied according to the functional limitations associated with knee OA severity according to VAS and WOMAC. The coefficient of determination of the cross-validated regression model is 0.85 for estimating WOMAC, 0.82 for pain, 0.85 for stiffness, and 0.85 for physical function, as well as VAS scores, utilizing the gait features. SHAP explanation revealed that greater co-contraction of lower extremity muscles during the weight acceptance and swing phases indicated more severe knee OA. The identified muscle co-activation patterns may be utilized as objective candidate outcomes to better understand the severity of knee OA.
Equivalence study of the resin-dentine interface of internal tunnel restorations when using an enamel infiltrant resin with ethanol-wet dentine bonding
Authors: Kielbassa Andrej M. , Summer Sabrina , Frank Wilhelm , Lynch Edward , Batzer Julia-Susanne 
Published: May 2024

AbstractThis preregistered ex vivo investigation examined the dentinal hybrid layer formation of a resinous infiltrant (Icon), with reference to both thickness (HLT) and homogeneity when combined with modified tunnel preparation (occlusal cavity only) and internal/external caries infiltration. The adhesives Syntac and Scotchbond MP were used as controls (Groups 1 and 3) or in combination with Icon (Groups 2 and 4). A split-tooth design using healthy third molars from 20 donors resulted in 20 prepared dentine cavities per experimental group. The cavity surfaces (n = 80) were etched (37% H3PO4), rinsed, and air-dried. Rewetting with ethanol was followed by application of the respective primers. After labeling with fluorescent dyes, either Syntac Adhesive/Heliobond or Scotchbond MP Adhesive was used alone or supplemented with Icon. HLT, as evaluated by scanning electron microscopy, did not significantly differ (P > 0.05), and confocal laser scanning microscopy revealed homogeneously mixed/polymerized resin-dentine interdiffusion zones in all groups. Icon can be successfully integrated into an ethanol-wet dentine bonding strategy, and will result in compact and homogeneous hybrid layers of comparable thickness considered equivalent to the non-Icon controls, thus allowing for preservation of the tooth’s marginal ridge and interdental space in the case of internal/external infiltration of proximal caries.
Analysis of the synergistic benefits of typical technologies for pollution reduction and carbon reduction in the iron and steel industry in the Beijing–Tianjin–Hebei region
Authors: Wen Wei , Deng Zifan , Ma Xin , Xing Yi , Pan Chongchao , Liu Yusong , Zhang Han , Tharaka W. A. N. D. , Hua Tongxin , Shen Liyao 
Published: May 2024

AbstractWith its high energy consumption and pollutant emissions, the iron and steel industry is a significant source of air pollution and carbon emissions in the Beijing–Tianjin–Hebei (BTH) region. To improve air quality and reduce greenhouse gas emissions, a series of policies involving ultra-low emission, synergistic reduction of pollution, and carbon application have been implemented in the region. This study has assessed air pollutant and CO2 emission patterns in the iron and steel industry of the region by employing co-control effects coordinate system, marginal abatement cost curve, and numerical modeling, along with the synergistic benefits of typical technologies. The results have demonstrated that: (1) the intensive production activities pertinent to iron and steel enterprises has contributed greatly to the emission in Tangshan and Handan, where the sintering process is the main source of SO2, NOx, PM2.5, and CO, accounting for 64.86%, 55.15%, 29.98%, and 46.43% of the total emissions, respectively. (2) Among the typical pollution control and reduction measures, industrial restructuring and adjustment of the energy-resource structure have led to the greatest effects on emission reduction. Technologies exhibiting great potential in emission reduction and high-cost efficiency such as Blast Furnace Top Gas Recovery Turbine Unit (TRT) need to be promoted. (3) In Tangshan city with the highest level of steel production, the iron and steel production activities contributed to the concentration of 30.51% of PM2.5, 50.67% of SO2, and 42.54% of NO2 during the non-heating period. During the heating period, pollutants pertinent to the combustion of fossil energy for heating have increased, while iron and steel induced emissions have decreased to 23.7%, 34.32%, and 29.13%, respectively. By 2030, it is speculated that the contribution of the iron and steel industry to air quality will be significantly decreased as result of successful implementation of ultra-low emission policies and typical synergistic reduction technologies.
TCF7L1 regulates colorectal cancer cell migration by repressing GAS1 expression
Authors: King Carli M. , Ding Wei , Eshelman Melanie A. , Yochum Gregory S. 
Published: May 2024

AbstractDysregulated Wnt/β-catenin signaling is a common feature of colorectal cancer (CRC). The T-cell factor/lymphoid enhancer factor (TCF/LEF; hereafter, TCF) family of transcription factors are critical regulators of Wnt/β-catenin target gene expression. Of the four TCF family members, TCF7L1 predominantly functions as a transcriptional repressor. Although TCF7L1 has been ascribed an oncogenic role in CRC, only a few target genes whose expression it regulates have been characterized in this cancer. Through transcriptome analyses of TCF7L1 regulated genes, we noted enrichment for those associated with cellular migration. By silencing and overexpressing TCF7L1 in CRC cell lines, we demonstrated that TCF7L1 promoted migration, invasion, and adhesion. We localized TCF7L1 binding across the CRC genome and overlapped enriched regions with transcriptome data to identify candidate target genes. The growth arrest-specific 1 (GAS1) gene was among these and we demonstrated that GAS1 is a critical mediator of TCF7L1-dependent CRC cell migratory phenotypes. Together, these findings uncover a novel role for TCF7L1 in repressing GAS1 expression to enhance migration and invasion of CRC cells.
Abrupt reduction in shipping emission as an inadvertent geoengineering termination shock produces substantial radiative warming
Authors: Yuan Tianle , Song Hua , Oreopoulos Lazaros , Wood Robert , Bian Huisheng , Breen Katherine , Chin Mian , Yu Hongbin , Barahona Donifan , Meyer Kerry , Platnick Steven 
Published: May 2024

AbstractHuman activities affect the Earth’s climate through modifying the composition of the atmosphere, which then creates radiative forcing that drives climate change. The warming effect of anthropogenic greenhouse gases has been partially balanced by the cooling effect of anthropogenic aerosols. In 2020, fuel regulations abruptly reduced the emission of sulfur dioxide from international shipping by about 80% and created an inadvertent geoengineering termination shock with global impact. Here we estimate the regulation leads to a radiative forcing of$$+0.2\pm 0.11$$+0.2±0.11Wm−2averaged over the global ocean. The amount of radiative forcing could lead to a doubling (or more) of the warming rate in the 2020 s compared with the rate since 1980 with strong spatiotemporal heterogeneity. The warming effect is consistent with the recent observed strong warming in 2023 and expected to make the 2020 s anomalously warm. The forcing is equivalent in magnitude to 80% of the measured increase in planetary heat uptake since 2020. The radiative forcing also has strong hemispheric contrast, which has important implications for precipitation pattern changes. Our result suggests marine cloud brightening may be a viable geoengineering method in temporarily cooling the climate that has its unique challenges due to inherent spatiotemporal heterogeneity.
Group‐weighted oscillatory containment for multiple robots under heterogeneous cooperation and competition
Authors: Zhao L. Y. , Ren Y. , Li W. , Liang P. 
Published: May 2024

AbstractThe group‐weighted containment (GWC) problem is studied for swarms of robots, where the information flow among agents is heterogeneous (weighted) cooperative‐competitive and the whole networked systems are composed of multiple different groups. Each group is formed by multiple harmonic oscillator leaders and multiple robot followers governed by Euler‐Lagrange (EL) equations. After introducing the definition of group‐weighted containment to the networked robot systems, the control algorithms for the agents containing followers and leaders are formulated over newly weighted cooperative‐competitive network. Some necessary conditions for solving the weighted containment control problem are established. It is shown that the followers in every group can achieve a kind of novel coordinated behaviors. Specifically, the followers can converge to the dynamic convex hull spanned by the corresponding leaders' weighted coordinates under some conditions. Simulation results are provided to illustrate the effectiveness of the proposed control schemes.
Clinical Significance of Hyperhomocysteinemia in Free Flap Failure: A Case Report
Authors: Menjeta Abeje Brhanu , Jeong Hyung Hwa , Kim Tae Hyung , Jeong Seongsu , Pak Changsik John , Suh Hyunsuk Peter , Hong Joon Pio 
Published: May 2024

AbstractFailure of a microvascular free flap remains rare, yet multiple failures can occur, particularly in the presence of hypercoagulable conditions. This case series highlights our experience with a rare hypercoagulable state: hyperhomocysteinemia.We present two cases of patients with hyperhomocysteinemia in this report. High-dose heparinization was administered to both patients, resulting in successful salvage of one flap and failure of the other. Notably, one patient had a history of prior free flap failures. However, after correcting hyperhomocysteinemia, subsequent free flaps were successful.In cases of detected complications, a coagulability study is warranted, and adjustments to anticoagulation treatment may be necessary. Furthermore, when a history of flap failures is evident, screening for hyperhomocysteinemia may be warranted, with correction made prior to reconstruction.
Comparative Study of Degree of Great Toe Movement after Complete and Partial Flexor Hallucis Longus Harvest in Free Fibula Flap
Authors: Agnihotri Ishan , Nayak Bibhuti Bhusan , Lakhotia Puja , Patnaik Aashish , Mohanty Rasmi Ranjan 
Published: May 2024

Abstract
Background The flexor hallucis longus (FHL) muscle is crucial in fine motor control of the great toe but the muscle is often sacrificed in free fibula flap (FFF) reconstruction. The aim of this study was to compare great toe movement between complete and partial FHL resection during FFF harvest to see if FHL can be left behind (without undergoing fibrosis) in situ when bulk is not required at the recipient site.
Methods A prospective, cross-sectional, observational study was performed including patients undergoing FFF harvest over a 2-year period. Movement of great toe interphalangeal joint was recorded of operated and unoperated legs in patients undergoing partial and complete FHL harvest and data analyzed.
Results There was a statistically significant (p < 0.05) difference between the two groups of patients.
Conclusion FHL can be safely left in situ in patients not requiring bulk at the recipient site as blood supply, nerve supply, and muscle function are not compromised in partial FHL harvest. Further image-based and dye-based studies are warranted.
Tailoring of ALT Flap for Optimizing Donor Site Morbidity
Authors: Bag Soumya Kanti , Das Cinjini 
Published: May 2024

AbstractWide and irregular-shaped defects at the lower trunk region are not uncommon following wide local excision of tumors. Pedicled anterolateral thigh (ALT) perforator flap has been the workhorse for these types of defects. But, in most of the cases flap donor sites cannot be closed primarily due to wide and irregular-shaped flap requirement. We propose a method of harvesting ALT flap in elliptical shape, dividing it into two or more geometrically predesigned islands based on perforators and rearranging them to fit into the defect, and thus achieving primary closure of the flap donor site.
Use of a Smartphone Digital Goniometer Combined with the Freehand Pedicle-Probing Technique for Repair of a Comminuted L6 Fracture in a 4 kg Dog
Authors: Mullins Ronan A. , Santos Bruno , Jamont Wiktoria 
Published: May 2024

AbstractA 10-month-old, 4 kg, Bichon Frise cross was referred for surgical stabilization of a highly comminuted L6 vertebral fracture after a road traffic accident. Nonambulatory paraparesis was present, with weak voluntary motor function in both pelvic limbs. Computed tomography (CT) of T6 to Cd1 identified a highly comminuted fracture of vertebral body and cranial endplate of L6 with severe narrowing of vertebral canal. A left-sided L6 pediculectomy was performed. The cauda equina was mildly bruised. Smaller bone fragments were removed, whereas larger bone fragments were depressed ventrally. Two 1.5-mm cortical screws were inserted into pedicles of L7 and a further two 2.0-mm screws into L5 vertebral body using the pedicle-probing technique. Following exposure of underlying cancellous bone, a smartphone digital goniometer, held by a nonsterile assistant, was used to guide advancement of a blunted Kirschner wire acting as a probe according to preoperative CT-determined safe angles. Postoperative CT identified excellent vertebral column alignment with improvement in spinal cord compression and optimal placement of implants at L5 and L7 (grade 1 modified Zdichavsky). Repeat CT at 3 months postoperatively identified well-seated implants. This report highlights that use of a smartphone goniometer may be a useful adjunct to the freehand pedicle-probing technique to guide correct trajectory of the probe and may also have application in other regions of the spine.