bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Perspective on Interventional Practices and Engagement of Adolescents for Their Overall Development and Well-Being
Authors: Mahapatro Meerambika , Roy Sudeshna , Nayar Poonam , Garikai Mantiziba Edmund 
Published: February 2025

Background: Adolescence is marked by rapid neurodevelopmental changes, including a significant shift in self-perception and worldview. Factors such as rapid urbanization, technological advancements, excessive social networking, media influences, and unfiltered information overload contribute to acute confusion among adolescents. This is exacerbated by peer pressure, a lack of essential life skills, and an urge to move away from traditional family values, resulting in mental health challenges. Objective: The article aims to describe intervention practices, policies, and engagement of adolescents for development and well-being. Methodology: The study adopts a narrative review approach, focusing on the adolescent population (aged 10–19 years) with specific emphasis on India. Literature published from 2015 onward is reviewed, and thematic analysis is conducted using electronic database searches with keywords aligned to Medical Subject Headings (MeSH). The findings are categorized into three thematic areas: family level, school level, and state level. Findings: Adolescent mental health is recognized, yet there remains a gap in addressing the full spectrum of mental health issues and overcoming barriers to implementing interventions across all levels. Effective family communication has been shown to significantly impact adolescents’ psychological well-being. Integrating life skills education, including yoga, into school curricula can further support preventive efforts through awareness campaigns, workshops, and peer-led programs. These integrated approaches can enhance understanding of how family and school environments influence adolescent mental health. Conclusion: Sustainable preventive intervention practices targeting social capital and social cohesion development for adolescent development and mental well-being are imperative and needed to be effectively delivered.
Midline catheter insertion as a strategic component of intravenous infusion: A single-centre retrospective analysis
Authors: Cichowlas Grzegorz , Fornal Izabela , Latos Maciej , Kosson Dariusz 
Published: February 2025

Background: Intravenous infusion is a key aspect of therapy in hospitalised patients. Choosing the right vascular catheter is important to minimise damage to the patient’s tissues, improve the quality of medical care and reduce costs associated with treatment complications. The purpose of this study was to review the effectiveness of midline catheters as a strategic component of intravenous infusions in a Polish hospital. Material and methods: The study material consists of medical records of patients with midline catheters at Czerniakowski Hospital in Warsaw over the period from 5th October 2021 to 19th May 2023. An analysis of 341 infusion observation charts was performed, excluding illegible and incomplete data. In this article, all of the catheters we used were inserted under ultrasound guidance. Results: The type of vein chosen has no significant effect on the catheter dwell time ( p = 0.984). Catheter length correlates with catheter dwell time ( r = 0.133; p = 0.016). Catheters with a length of 15 cm have the longest dwell time, while those with a length of 20 cm have the shortest. Completion of therapy or patient death was the most common reason for catheter removal (46.9%). Catheter size had an impact on catheter dwell time ( p = 0.034). The text presents observations regarding the relationship between catheter diameter and total aspiration time, based on all days during which blood was aspirated through the catheter. The statistical test results ( H = 118.268; p < 0.001) indicate a significant impact of catheter diameter size on total aspiration time. Conclusions: Midline catheters are an effective solution for patients with difficult vascular access, increase the possibility of intravenous therapy. Moreover, they improve patient comfort and reduce the number of multiple cannulations. Developing vascular access teams can better control infusion management and care.
Prevalence, trends, and correlates of HIV, syphilis, and HCV infections among male attendees at STD clinics in Southwest China: a 13-year cross-sectional study (2010–2022)
Authors: Tao Chunxing , Che Jianhua , Huang Rongye , He Jinfeng , Wu Zhenxian , Liang Fengfeng , Cai Jie , Ou Yanyun , Bao Lijuan , Ye Li , Liang Hao , Lin Zhaosen , Nong Aidan , Liang Bingyu 
Published: February 2025

Abstract

Background
Sexually transmitted infections (STIs) impose a substantial health burden and pose a significant threat to human health. However, data regarding long-term epidemiology patterns of STIs among high-risk groups are scarce. This study aimed to evaluate the prevalence, trends, and correlates of HIV, syphilis, and HCV among male attendees at sexually transmitted disease (STD) clinics in Southwest China.

Methods
Serial cross-sectional surveys were performed annually among male STD clinic attendees in Southwest China from 2010 to 2022. Blood specimens were collected to test HIV, syphilis, and HCV infections. Mann-Kendall trend test was used to assess the trends of HIV, syphilis, and HCV prevalence. Rare even logistic regression model (relogit) was used to identify correlates of HIV, syphilis, and HCV infections.

Results
This study included a total of 23,964 male attendees at STD clinics. The prevalence of HIV, syphilis, and HCV among participants was 0.98%, 2.16%, and 0.61%, respectively. While the prevalence of syphilis and HCV decreased from 3.64% to 1.81% in 2010 to 1.05% and 0.38% in 2022, the HIV prevalence did not show a downward trend. Relogit analysis revealed that participants with a history of STD had significantly increased risks of HIV (aOR = 1.90, 95%CI: 1.14–3.15) and HCV (aOR = 4.91, 95%CI: 3.22–7.49) infections. Participants who had ever engaged in homosexual behavior had significantly increased risks of HIV (aOR = 14.66, 95%CI: 5.49–39.14) and syphilis (aOR = 3.95, 95%CI:1.41–13.71) infections. Age also played a role, with those aged 50 years and above having a higher likelihood of HIV infection (aOR = 2.55, 95%CI: 1.91–3.39), while those under 50 years were more likely to be infected with HCV (aOR = 1.94, 95%CI: 1.19–3.16). Moreover, individuals of Han ethnicity were more likely to be infected with syphilis (aOR = 2.12, 95%CI: 1.75–2.57) and HCV (aOR = 1.65, 95%CI: 1.16–2.33). Being married or cohabiting increased the likelihood of syphilis infection (aOR = 1.40, 95%CI: 1.09–1.80), and a history of intravenous drug use (IDU) significantly increased the risk of HCV infection (aOR = 10.97, 95%CI: 5.21–23.12).

Conclusions
This study found a low prevalence of HIV, syphilis, and HCV among male attendees at STD clinics. Despite the declining prevalence of syphilis and HCV, HIV prevalence did not show a downward trend. This underscores the crucial need for continued and targeted prevention efforts, especially promoting STIs testing for men who have sex with men (MSM) and individuals with a history of intravenous drug use (IDU).
Characterization of spreading depolarizations in swine following superior sagittal sinus occlusion: a novel gyrencephalic model study
Authors: Sanchez-Porras Renan , Ramírez-Cuapio Francisco L. , Gutiérrez-Herrera Mildred A. , Puig-Lagunes Ángel Alberto , Albiña-Palmarola Pablo , López-Navarro Juan M. , Suárez-Gutiérrez Marcos Alejandro , Díaz-Peregrino Roberto , Sandoval-Lopez Diego A. , Fischer Gregor , Vazifehdan Farzam , Woitzik Johannes , Santos Edgar 
Published: February 2025

Abstract
Cerebral sinus thrombosis, which constitutes a small percentage of all strokes, usually affects young individuals and can lead to venous stroke. Ischemic and hemorrhagic Stroke are associated with Spreading Depolarization (SD) waves in brain tissue, which propagate through the affected areas and cause a transient disruption of ionic homeostasis and neuronal function. This interaction highlights the complexity of the neurological consequences associated with SD. In this study, we investigated the occurrence of SDs following the occlusion of the superior sagittal sinus (SSS) in a gyrencephalic model, specifically swine. To instigate an occlusion, we surgically clipped the middle third of the SSS. The animals were grouped and monitored using one of three methods: electrocorticography (ECoG) alone, ECoG with intrinsic optical signal (IOS) imaging, or ECoG in conjunction with laser speckle contrast and oxygen imaging (LSCI). Post-mortem, the brains were analyzed using 2,3,5-triphenyl tetrazolium chloride (TTC) staining to check for venous infarction. Our results confirmed the spontaneous occurrence of SDs in the gyrencephalic swine brain after SSS occlusion, which was detectable via all monitoring methodologies. SD activity was most frequent in the first hour post-occlusion, subsequently diminishing. IOS imaging identified four unique hemodynamic responses, while TTC staining indicated no infarction. This research is the first to document SDs in the gyrencephalic swine brain following SSS occlusion, laying the groundwork for future investigations in both animal models and human clinical studies.
Unveiling the potential of CLL-1: a promising target for AML therapy
Authors: Soleimani Samarkhazan Hamed , Zehtabcheh Sara , Seraji Hamideh Rahmani , Beqaj Safedin H. , Tayefeh Shamim , Mohammadi Mohammad Hossein , Aghaei Mojtaba 
Published: February 2025

Abstract
Acute myeloid leukemia (AML) remains a formidable blood cancer, despite recent advances in treatment. A significant challenge persists in improving patient outcomes, particularly in addressing relapse and treatment resistance. Identifying new therapeutic targets is critical for advancing AML therapy. C-type lectin-like molecule-1 (CLL-1) has emerged as a promising therapeutic target in AML. This cell surface receptor is highly expressed on AML blasts and demonstrates stable expression throughout disease progression. CLL-1’s consistent presence makes it an ideal candidate for monitoring minimal residual disease (MRD), which is a critical indicator for predicting relapse. Beyond its utility as a diagnostic marker, CLL-1 offers exciting potential in the development of immunotherapies. Emerging strategies, such as CAR-T-cell therapy and antibody-drug conjugates (ADCs), are being investigated to leverage the immune system against CLL-1-expressing AML cells. This review examines the structure, function, and expression patterns of CLL-1 in AML and other hematologic malignancies, providing insights into its role in disease pathogenesis and treatment potential. Exploring CLL-1 as a target for diagnosis, MRD monitoring, and immunotherapy opens new avenues for AML treatment. A deeper understanding of its relationship with AML pathogenesis will aid in the development of targeted therapies, offering hope for improved patient outcomes in the future.
Freeze-dried herbal Kaempferia galanga supplementation effectively modulates hyperglycemia-induced oxidative stress and apoptosis in diabetic BALB/c mice
Authors: Nonglang Flavius Phrangsngi , Snaitang Revelbornstar , Roy Dhritiman , Bhan Surya 
Published: February 2025

Abstract

Background
A dysfunction in insulin secretion or action leads to hyperglycemia. Hyperglycemia then causes the activation of pathways that result in increased production of reactive oxygen and nitrogen species (ROS/RNS) levels, ultimately causing oxidative stress. Oxidative stress overload then causes cellular damage and also promotes the increased activation of the apoptosis pathway inducing cell death. Thus, regulation of glucose homeostasis to prevent hyperglycemia is crucial. In this study, the potential protective effect of Kaempferia galanga herbal extract (KGE) on hyperglycemia-induced oxidative stress and apoptosis was investigated.

Result
In this study, Kaempferia galanga (KG) herbal extracts, namely aqueous (KGA), ethanolic (KGE), methanolic (KGM), and chloroform (KGC), were tested for their antioxidant activity. In in vitro antioxidant assays, KG ethanolic extract (KGE) has the highest antioxidant activity out of all the extracts. High-performance thin layer chromatography phytochemical fingerprinting (HPTLC) analysis confirms that the presence of more antioxidant compounds in herbal KGE and ethyl-p methoxy cinnamate (EPMC) was the active phytochemical. Thus, KGE was chosen for in vivo studies. An intraperitoneal streptozotocin (STZ) administration produced a diabetic mouse model. In vivo herbal KGE treatment positively modulates SOD and CAT gene and protein expression in diabetic mice. Tissue protection from herbal KGE supplementation is supported by liver electron microscopy. In diabetic mice, herbal KGE supplementation reduces DNA fragmentation in the liver, kidney, pancreas, and heart by upregulating the gene and protein expression of anti-apoptotic BCL-2, inhibiting BAX expression, and ultimately inhibiting caspase-3 (CAS-3) expression. Herbal KGE supplementation in diabetic mice maintains insulin levels in serum and pancreas, indicating its protective role in preventing pancreatic damage or promoting β cell regeneration. Molecular docking analysis shows EPMC's high binding affinity for CAS-3, BAX, and BCL-2 compared to metformin suggesting that it may be responsible for modulating apoptotic protein expression.

Discussion
Herbal KGE supplementation protects against diabetes-induced tissue damage and apoptosis by reducing hyperglycemia-induced oxidative stress and apoptosis, and EPMC may be the active component eliciting the effect.
Analysis on the Impact of U.S. FDA’s Narrow Therapeutic Index Bioequivalence Criteria on Generic Drug Applications
Authors: Anim Anno Krista , Mina Mirette , Zhang Zhen , Zhang Lei , Jiang Wenlei 
Published: February 2025

Abstract
Since 2012, the U.S. Food and Drug Administration (FDA) has developed classification criteria of narrow therapeutic index (NTI) drug products and tightened bioequivalence (BE) standards for these products by recommending a fully replicated, two-sequence, two-treatment, four-period crossover study design where BE is based on passing both scaled average BE criterion and within-subject variability comparison criterion, as well as the average BE criterion of 80.00%-125.00%. Currently, the BE study design and criteria for NTI drugs are somewhat different across regulatory agencies. The objective of this study is to survey pharmacokinetic BE data of abbreviated new drug applications (ANDAs) of NTI drugs submitted to the FDA with initial submission dates between January 1, 2013 and October 1, 2022 to identify the impact of FDA’s current BE approach on generic NTI approval. Thirty-three NTI drug products from 100 ANDAs were identified with 93 ANDAs included in analysis. Eighty-seven ANDAs had four-way crossover studies, with 69 and 106 fed and fasting BE studies, respectively. For all NTI drugs, the range of average SWR for Cmax, AUCt, and AUCinf was between 0.05 and 0.27. Of the 20 studies that failed BE, 90%, 5%, and 5% failed reference scaled criteria only, variability comparison criteria only, and both, respectively. Further communication of this work with global regulatory agencies and the scientific community will help better understand current FDA NTI BE criteria and review experiences. These efforts will support the development of harmonized BE criteria for NTI drugs, in turn improving patient access to generic NTI drugs.

Graphical Abstract
The Road to Serfdom and the Definitions of Socialism, Planning, and the Welfare State, 1930–1950
Authors: Benzecry Gabriel F. , Jensen Nicholas , Smith Daniel J. 
Published: February 2025

Abstract
There is a long-standing debate about whether the central hypothesis of F. A. Hayek's The Road to Serfdom, warning of the incompatibility between socialism and democracy, extended to welfare states. The empirical validity of Hayek's hypothesis hinges on his definition of socialism. We build on previous works contextualizing and interpreting The Road to Serfdom by examining the common definitions of socialism, capitalism, and the welfare state primarily between 1930 and 1950 according to (1) socialist intellectuals, especially those Hayek was engaging in The Road to Serfdom, (2) reviews of and responses to Hayek's book, and (3) prominent politicians and other public intellectuals in London. We find that socialism was commonly understood to mean economic planning under state ownership or control of the means of production. Those advocating for the expansion of welfare programs often held that state control or ownership of the means of production was necessary to fund social redistribution. Our findings bolster the interpretation of Hayek's central hypothesis in The Road to Serfdom as being limited to economic planning under state control or ownership of the means of production.
Predicting patent challenges for small-molecule drugs: A cross-sectional study
Authors: Memedovich Ally , Steele Brian , Orr Taylor , Chaudhry Shanzeh , Tadrous Mina , Kesselheim Aaron S. , Hollis Aidan , Beall Reed F. 
Published: February 2025

Background
The high cost of prescription drugs in the United States is maintained by brand-name manufacturers’ competition-free period made possible in part through patent protection, which generic competitors must challenge to enter the market early. Understanding the predictors of these challenges can inform policy development to encourage timely generic competition. Identifying categories of drugs systematically overlooked by challengers, such as those with low market size, highlights gaps where unchecked patent quality and high prices persist, and can help design policy interventions to help promote timely patient access to generic drugs including enhanced patent scrutiny or incentives for challenges. Our objective was to characterize and assess the extent to which market size and other drug characteristics can predict patent challenges for brand-name drugs.

Methods and findings
This cross-sectional study included new patented small-molecule drugs approved by the FDA from 2007 to 2018. Market size, patent, and patent challenge data came from IQVIA MIDAS pharmaceutical quarterly sales data, the FDA’s Orange Book database, and the FDA’s Paragraph IV list. Predictive models were constructed using random forest and elastic net classification. The primary outcome was the occurrence of a patent challenge within the first year of eligibility. Of the 210 new small-molecule drugs included in the sample, 55% experienced initiation of patent challenge within the first year of eligibility. Market value was the most important predictor variable, with larger markets being more likely to be associated with patent challenges. Drugs in the anti-infective therapeutic class or those with fast-track approval were less likely to be challenged. The limitations of this work arise from the exclusion of variables that were not readily available publicly, will be the target of future research, or were deemed beyond the scope of this project.

Conclusions
Generic competition does not occur with the same timeliness across all drug markets, which can leave granted patents of questionable merit in place and sustain high brand-name drug prices. Predictive models may help direct limited resources for post-grant patent validity review and adjust policy when generic competition is lacking.
Geographical mapping and seroprevalence of Burkholderia pseudomallei amongst livestock species in Lao People’s Democratic Republic
Authors: Zheng Suwei , Young James R. , Khounsy Syseng , Phommachanh Phouvong , Christensen Peter , Theppangna Watthana , Hughes Tom , Temmerath Adisone , Inthavong Alex , Inthapanya Phoummavanh , Panyasith Sivone , Phommasone Koukeo , Limmathurotsakul Direk , Ashley Elizabeth A. , Blacksell Stuart D. , Ward Michael P. 
Published: February 2025

The Gram-negative bacterium Burkholderia pseudomallei causes a severe infectious disease known as melioidosis in humans and animals. It is considered endemic in tropical countries, including Thailand, Lao PDR (Laos), and Northern Australia. B. pseudomallei is a saprophyte found in contaminated soil and surface water. Humans and animals can become infected via direct exposure to contaminated water or soil and inhalation of dust or water droplets. Despite the high morbidity and mortality rates of melioidosis, there is a lack of knowledge of its geographical distribution and seroprevalence, even within endemic countries, raising a significant public health concern. For a better understanding of melioidosis in livestock in Laos, both as an animal health concern and as an indicator of human risk, we collected serum samples from an abattoir monitoring program for B. pseudomallei antibody testing using the Indirect Haemagglutination Assay (IHA). Out of the 917 sera collected, major findings included the identification of a significant cluster (p = 0.041) in the southwest border region adjoining northeastern Thailand, in the province of Savannakhet in Laos. Sera collected in January 2020 had the highest B. pseudomallei seroprevalence (17.0%), and cattle had the highest seroprevalence (22.8%), followed by buffalo (19.7%) and swine (4.0%). The B. pseudomallei seroprevalence results among the common livestock species and the maps generated can assist with future monitoring, prevention, and detection of melioidosis in Laos.
Construction of a nomogram to predict urethral stricture after transurethral resection of the prostate: A retrospective cohort study
Authors: Wan Mokhter Wan Mokhzani , Duan Xiaoping , Yang Jin , Mohamed Daud Mohamed Ashraf 
Published: February 2025

Background
To investigate the risk factors for urethral stricture (US) in patients with benign prostatic hyperplasia (BPH) after transurethral resection of the prostate (TURP) and to construct a nomogram model with predictive features.

Methods
Clinical data of 400 patients with BPH who underwent TURP between June 2020 and June 2023 at Chengdu University Hospital were retrospectively collected. The data were divided into US group and no US group. Univariate and multivariate logistic regression analyses were performed sequentially to identify independent risk factors associated with US. Based on the results of the multivariate analysis, a nomogram model predicting the risk of US was constructed. We assessed the discriminatory power and calibration of the models using the C index, ROC curves, and calibration plots. In addition, we performed a decision curve analysis to validate the clinical utility of the model.

Results
Data from a total of 400 patients were included in this study, and 35 (8.75%) were diagnosed with US. The results of univariate and multivariate analyses indicated that the following five factors age, prostate size, Preoperative indwelling catheter, Preoperative urethral dilation, Postoperative indwelling catheter time were independent influences on the risk of US. Nomogram model of US was constructed using these independent influences. The area under the curve (AUC) of the subject’s operating characteristic was 0.916 (95% CI: 0.868–0.959), and after internal validation, the corrected C-index remained at 0.916. This further validates the accuracy and reliability of the predictive model. Calibration plots and decision curve analyses demonstrated the good clinical value of the column-line diagram model.

Conclusions
The nomogram model we constructed can have some guidance in clinical work.