bluuebunny/crossref_metadata_2025_split huggingface dataset:
Homeodomain‐interacting protein kinase2 in human idiopathic pulmonary fibrosis
Authors: Ricci Alberto , Cherubini Emanuela , Ulivieri Alessandra , Lavra Luca , Sciacchitano Salvatore , Scozzi Davide , Mancini Rita , Ciliberto Gennaro , Bartolazzi Armando , Bruno Pierdonato , Graziano Paolo , Mariotta Salvatore 
Published: June 2012

AbstractHomeodomain‐interacting protein kinase 2 (Hipk2) is an emerging player in cell response to genotoxic agents that contributes to the cell's decision between cell cycle arrest or apoptosis. HIPK2 acts as co‐regulator of an increasing number of transcription factors and modulates many different basic cellular processes such as apoptosis, proliferation, DNA damage response, differentiation. Idiopathic pulmonary fibrosis (IPF) is characterized by an anatomical disarrangement of the lung due to fibroblast proliferation, extracellular matrix deposition and lung function impairment. Although the role of inflammation is still debated, attention has been focused on lung cell functions as fibroblast phenotype and activity. Aim of the present study was to analyze the loss of heterozygosity (LOH) at HIPK2 locus 7q32.34 in human lung fibroblasts and the HIPK2 expression in 15 IPF samples and in four primary fibroblast cell cultures isolated from IPF biopsies using semi‐quantitative RT‐PCR, Western blots and immunohistochemistry. We demonstrated a frequency of LOH in IPF fibroblasts of 46% for the internal D7S6440 microsatellite and 26.6% for the external D7S2468 microsatellite. Furthermore, we demonstrated low HIPK2 protein expression in those fibroblasts from IPF patients that present the HIPK2 LOH. The restoration of HIPK2 expression in IPF derived cells induced a significant reduction of chemoresistance after treatment with cisplatin. The results obtained allow us to hypothesize that HIPK2 dysfunction may play a role in fibroblasts behavior and in IPF pathogenesis. HIPK2 may be considered as a novel potential target for anti‐fibrosis therapy. J. Cell. Physiol. 228: 235–241, 2013. © 2012 Wiley Periodicals, Inc.
Peritraumatic distress: Its relationship to posttraumatic stress and complicated grief symptoms in sudden death survivors
Authors: Hargrave Petrina A. , Leathem Janet M. , Long Nigel R. 
Published: June 2012

AbstractAlthough sudden death has been linked to posttraumatic stress disorder (PTSD), its role in complicated grief (CG) and sudden death survivors is unknown. This questionnaire study investigated the role of peritraumatic distress in PTSD and CG symptoms in adults (n = 125) an average of 28.37 months (SD = 3.12) after a loved one's sudden death. The Peritraumatic Distress Inventory, Impact of Event Scale‐Revised, and Inventory of Complicated Grief were administered to assess symptoms of peritraumatic distress, PTSD, and CG, respectively. Peritraumatic distress was the strongest correlate of both PTSD (β = .42, p < .001) and CG (β = .39, p < .001) symptoms, in a model containing current distress (Hopkins Symptom Checklist‐21). Peritraumatic distress may be a key mechanism in the development of both PTSD and CG, therefore suddenly bereaved individuals reporting higher peritraumatic distress may be at risk of both adverse trauma and grief reactions.
Synthesis of α,ω‐Isocyanate–Telechelic Poly(methyl methacrylate)
Authors: Greving Nebia , Keul Helmut , Millaruelo Marta , Weberskirch Ralf , Moeller Martin 
Published: June 2012

AbstractThe preparation of α,ω‐isocyanate–telechelic poly(methyl methacrylate) using RAFT polymerization and two postpolymerization modification steps is presented. The synthetic strategy includes the RAFT polymerization of methyl methacrylate, which results in a hetero telechelic polymer. In the first modification step by radical exchange, a carboxylic acid homo telechelic PMMA was successfully prepared. Second, the carboxylic acid end groups are reacted with hexamethylene diisocyanate in excess and magnesium chloride as a catalyst. Under mild reaction conditions (80 °C, 4 h), the isocyanate homo telechelic PMMA is obtained. A conversion of 86% of the carboxylic acid end groups was achieved.
Kontinuierlich produzieren
Authors: Bauer Tobias 
Published: June 2012

AbstractStrömungschemische Verfahren dienen zunehmend der Erforschung von Synthesewegen. Insbesondere mikrofluidische Apparate und Bauteile, die bei höheren Temperaturen und Drucken betrieben werden und mit schneller Messtechnik ausgestattet sind, geben umfangreiche Informationen über den Syntheseweg.
Die Metallabscheider
Authors: Jordan Manfred , Dietterle Michael 
Published: June 2012

AbstractDie Galvanotechnik ist als relativ kleine Branche in der Öffentlichkeit nicht so präsent, wie es ihrer Bedeutung als Schlüsseltechnologie für viele Industriezweige angemessen wäre. In der Wertschöpfungskette nimmt sie eine wichtige Position ein.
Biotech erwartet stärkeres Bekenntnis der Politik
Authors: Bengs Holger 
Published: June 2012

AbstractDer deutschen Biotechindustrie geht es den Umständen entsprechend gut. Ob es für den großen internationalen Sprung reicht, ist unsicher. Politiker sind gefordert, endlich die Rahmenbedingungen für kleine und mittlere Unternehmen angemessen zu verbessern.
Die Trends in der Prozessindustrie
Authors: Graf Katharina 
Published: June 2012

AbstractEnde Juni findet in Frankfurt am Main die 30. Achema statt. In Ausstellung, Kongress und Sonderveranstaltungen findet der Besucher Produkte, Dienstleistungen und Informationen rund um die Prozessindustrie. Neue Schwerpunkte sind Energiespeicherung und ‐nutzung sowie Bioökonomie.
Regularized integral equations and fast high‐order solvers for sound‐hard acoustic scattering problems
Authors: Bruno Oscar , Elling Tim , Turc Catalin 
Published: June 2012

SUMMARYThis text introduces the following: (1) new regularized combined field integral equations (CFIE‐R) for frequency‐domain sound‐hard scattering problems; and (2) fast, high‐order algorithms for the numerical solution of the CFIE‐R and related integral equations. Similar to the classical combined field integral equation (CFIE), the CFIE‐R are uniquely‐solvable integral equations based on the use of single and double layer potentials. Unlike the CFIE, however, the CFIE‐R utilize a composition of the double‐layer potential with a regularizing operator that gives rise to highly favorable spectral properties—thus making it possible to produce accurate solutions by means of iterative solvers in small numbers of iterations. The CFIE‐R‐based fast high‐order integral algorithms introduced in this text enable highly accurate solution of challenging sound‐hard scattering problems, including hundred‐wavelength cases, in single‐processor runs on present‐day desktop computers. A variety of numerical results demonstrate the qualities of the numerical solvers as well as the advantages that arise from the new integral equation formulation. Copyright © 2012 John Wiley & Sons, Ltd.
Terms used in patient safety related to medication: a literature review
Authors: Pintor‐Mármol Antonio , Baena María Isabel , Fajardo Paloma C. , Sabater‐Hernández Daniel , Sáez‐Benito Loreto , García‐Cárdenas María Victoria , Fikri‐Benbrahim Narjis , Azpilicueta Inés , Faus Maria José 
Published: June 2012

ABSTRACTPurposeThere is a lack of homogeneity in the terminology used in the context of patient safety related to medication. The aim of this review was to identify the terms and definitions used in patient safety related to medication within the scientific literature.MethodsOriginal and review articles that were indexed between 1998 and 2008 in MEDLINE and EMBASE and contained terms used in patient safety related to medication were included. Terms and definitions were extracted and categorised according to whether its definition referred to the process of medication use, or to the clinical outcome of medication use, or both.ResultsOf 2564 articles, 147 were included. Sixty terms used in patient safety related to medication with 189 different definitions were identified. Among terms that referred only to the process of medication use (n = 23), medication error provided the greatest number of definitions (n = 29). Among terms that referred only to the clinical outcome of medication use (n = 31), adverse drug event provided the greatest number of definitions (n = 15). Finally, among terms that referred both to the process of use and to the clinical outcome of medication use (n = 13), drug‐related problem provided the greatest number of definitions (n = 7).ConclusionsA multitude of terms and definitions are used in patient safety related to medication. This heterogeneity makes it difficult to compare the results among studies and to appreciate the true magnitude of the problem. Classifying and unifying the terminology is necessary to advance in patient safety strategies. Copyright © 2012 John Wiley & Sons, Ltd.
Techniques for characterization of charge carrier mobility in organic semiconductors
Authors: Kokil Akshay , Yang Ke , Kumar Jayant 
Published: June 2012

AbstractThe charge transport characteristics of organic semiconductors are one of the key attributes that impacts the performance of organic electronic and optoelectronic devices in which they are utilized. For improved performance in organic photovoltaic cells, light‐emitting diodes, and field‐effect transistors (FETs), efficient transport of the charge carriers within the organic semiconductor is especially critical. Characterization of charge transport in these organic semiconductors is important both from scientific and technological perspectives. In this review, we shall mainly discuss the techniques for measuring the charge carrier mobility and not the theoretical underpinnings of the mechanism of charge transport. Mobility measurements in organic semiconductors and particularly in conjugated polymers, using space‐charge‐limited current, time of flight, carrier extraction by linearly increasing voltage, double injection, FETs, and impedance spectroscopy are discussed. The relative merits, as well as limitations for each of these techniques are reviewed. © 2012 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2012
Does Internal Migration in Northern Ireland Increase Religious and Social Segregation? Perspectives from the Northern Ireland Longitudinal Study (NILS) 2001–2007
Authors: Shuttleworth Ian , Barr Paul James , Gould Myles 
Published: June 2012

ABSTRACTInternal migration, because of its selectivity, has been recognised in Britain, Europe, and the USA as a major influence on geographical patterns of ethnic and social segregation. Despite this, and despite its history of communal division, plus accounts which have emphasised population moves as a cause of segregation, far less academic attention has been paid to dynamic migration processes in understanding the evolution of spatial population patterns in Northern Ireland (NI). This paper attempts to address this gap by considering how far internal migration ‐ defined as address changes ‐ has redistributed the population with regard to (a) religion and (b) social deprivation between 2001 and 2007. Using data from the Northern Ireland Longitudinal Study (NILS), the paper finds that Catholics and Protestants move from and to the same sorts of places with regard to deprivation but that there was some evidence of differential mobility behaviour with regard to individual community affiliation and other individual socio‐demographic characteristics. However, there is no evidence for increases in either communal or social segregation. It is suggested that this is because relatively few people move, they move only short distances, and the current net redistributive impact of migration is therefore small. It is hypothesised that a much more dynamic population with regard to migration is needed to increase or decrease segregation. Copyright © 2012 John Wiley & Sons, Ltd.
Electronic states of mixed base pairs systems of dna and the effect of base composition and sequences on the band structures using screw axis translational symmetry
Authors: Xie Peng , Teramae Hiroyuki , Liu Kai , Aoki Yuriko 
Published: June 2012

AbstractWe perform the conventional band structure and local density of states (LDOS) calculations in the vicinity of the Fermi level at ab initio molecular orbital level with 6‐31G base set for one DNA duplex with repeated mononucleotide sequences and four DNA duplexes with repeated dinucleotide sequences in B form neutralized by Na+. The LDOS of six other DNA duplexes with repeated trinucleotide sequences in the same states are analyzed. The obtained results are compared with those by the band calculations based on periodic boundary condition using screw axis symmetry. The investigations focused on the influence of the base composition and base sequence on the DNA conductivity. The band structure and LDOS calculation results indicated that base guanine is more important for DNA conductivity than the other bases, and DNA conductivity varies with base sequence of DNA. Moreover, poly (dG) • poly (dC) shows the best conductor in our DNA duplex models. © 2012 Wiley Periodicals, Inc.
Theoretical models for the antitrypanosomal activity of thiosemicarbazone derivatives
Authors: Lozano N. B. H. , Weber K. C. , Honorio K. M. , Guido R. V. C. , Andricopulo A. D. , Da Silva A. B. F. 
Published: June 2012

AbstractThiosemicarbazones are cruzain inhibitors which have been identified as potential antitrypanosomal agents. In this work, several molecular properties were calculated at the density functional theory (DFT)/B3LYP/6‐311G* level for a set of 44 thiosemicarbazones. Unsupervised and supervised pattern recognition techniques (hierarchical cluster analysis, principal component analysis, kth‐nearest neighbors, and soft independent modeling by class analogy) were used to obtain structure–activity relationship models, which are able to classify unknown compounds according to their activities. The chemometric analyses performed here revealed that 12 descriptors can be considered responsible for the discrimination between high and low activity compounds. Classification models were validated with an external test set, showing that predictive classifications were achieved with the selected variable set. The results obtained here are in good agreement with previous findings from the literature, suggesting that our models can be useful on further investigations on the molecular determinants for the antichagasic activity. © 2012 Wiley Periodicals, Inc.
Concurrent phenomena at the transition region of selected elementary chemical reactions: An information‐theoretical complexity analysis
Authors: Esquivel Rodolfo O. , Molina‐Espíritu Moyocoyani , Dehesa Jesús S. , Angulo Juan Carlos , Antolín Juan 
Published: June 2012

AbstractIn this work, we have investigated in position (r) and momentum (p) spaces the concurrent phenomena occurring at the vicinity of the transition state (TS) (the so‐called transition region) of selected chemical reactions (such as the hydrogenic abstraction and the exchange hydrogenic reactions) by means of a broad set of single information‐theoretic functionals of the one‐particle density (such as the disequilibrium (D), exponential entropy (L), Fisher information (I) and the power entropy (J)) and composite information‐theoretic measures which includes various information planes (such as the I‐D, D‐L, and I‐J planes) and complexities of the Fisher‐Shannon and López‐Mancini‐Calbet (LMC) types. The analysis of the single functionals and the information planes revealed that these information‐theoretical elements can identify all the chemically significant regions, not only the reactant/product regions (R/P) and the TS but also those that are not present in the energy profile, such as the bond cleavage energy region (BCER), the bond breaking/forming regions (B‐B/F) and the charge transfer complex. Moreover, the analysis of the complexities shows that in position as well as in the joint (r‐p) spaces, the energy profile of the abstraction reaction bears the same information‐theoretical features of the LMC and FS measures. Finally, it is shown why most of the chemical features of interest (such as e.g., BCER and B‐B/F) are lost in the energy profile, being only revealed when particular information‐theoretical aspects of localizability (L or J), uniformity (D) and disorder (I) are considered. © 2012 Wiley Periodicals, Inc.
Investigating the Mechanism of Hysteresis Effect in Graphene Electrical Field Device Fabricated on SiO2 Substrates using Raman Spectroscopy
Authors: Xu Hua , Chen Yabin , Zhang Jin , Zhang Haoli 
Published: June 2012

AbstractThe hysteresis effect is a common problem in graphene field‐effect transistors (FETs). Usually, the external doping to graphene is considered to be responsible for the hysteresis behavior, but is not yet clearly understood. By monitoring the doping of graphene and the hysteresis in graphene FETs under different atmospheres using in situ Raman spectroscopy, it is confirmed that the electrochemical doping of O2/H2O redox couple to graphene is responsible for the hysteresis effect. In addition, Raman spectra of graphene on SiO2 substrate show stronger doping than that suspended, which indicates that SiO2 substrate plays an important role in the doping of graphene. Herein it is proposed that the doping species (H2O and O2) are bounded at the interface of graphene/SiO2 substrate by hydrogen‐bonds with the silanol groups on SiO2 substrate. The dynamic equilibrium process of the charge‐transfer between H2O/O2 redox couple and graphene under electrical field modulation is carefully analyzed using Marcus–Gerischer theory. This work provides a clear view to the mechanism of the hysteresis effect, and is of benefit to a reliable design to suppress the hysteresis in graphene FETs.
Topological susceptibility on the lattice and the three-flavour quark condensate
Authors: Bernard Véronique , Descotes-Genon Sébastien , Toucas Guillaume 
Published: June 2012

Abstract

We reanalyse the topological susceptibility assuming the possibility of a significant paramagnetic suppression of the three-flavour quark condensate and a correlated enhancement of vacuum fluctuations of
$ s\overline s $
pairs. Using the framework of resummed χPT, we point out that simulations performed near the physical point, with a significant mass hierarchy between u, d and s dynamical quarks, are not able to disentangle the contributions from the quark condensate and sea
$ s\overline s $
-pair fluctuations, and that simulations with three light quark masses of the same order are better suited for this purpose. We perform a combined fit of recent RBC/UKQCD data on pseudoscalar masses and decay constants as well as the topological susceptibility, and we reconsider the determination of lattice spacings in our framework, working out the consequences on the parameters of the chiral Lagrangian. We obtain (Σ(3; 2 GeV))1/3 = 243 ± 12 MeV for the three-flavour quark condensate in the chiral limit. We notice a significant suppression compared to the two-flavour quark condensate Σ(2; 2 GeV)/Σ(3; 2 GeV) = 1.51 ± 0.11 and we confirm previous findings of a competition between leading order and next-to-leading order contributions in three-flavour chiral series.
2‐[(E)‐{(1S,2R)‐1‐Hydroxy‐1‐phenylpropan‐2‐ylimino}methyl]phenol for Inhibition of Acid Corrosion of Mild Steel
Authors: Kesavan Devarayan , Muthu Tamizh Manoharan , Sulochana Nagarajan , Karvembu Ramasamy 
Published: June 2012

Abstract2‐[(E)‐{(1S,2R)‐1‐hydroxy‐1‐phenylpropan‐2‐ylimino}methyl]phenol has been synthesized and its influence on corrosion of mild steel in 1 M HCl solution has been studied by means of weight loss and electrochemical measurements under various circumstances. The inhibitor showed a maximum of 91 % of inhibition efficiency at 100 ppm. Interestingly, the inhibition efficiency has decreased on increasing the inhibitor concentration. This abnormal behavior is attributed to the release of phenolic hydrogen from the molecule. The mechanism of corrosion inhibition follows Langmuir adsorption isotherm. The negative ∆Gads indicates the spontaneous adsorption of the inhibitor on mild steel surface. Potentiodynamic polarization studies show that it is a mixed type inhibitor with predominant cathodic inhibition. UV–Visible spectroscopy of the inhibitor and inhibitor adsorbed on the mild steel confirmed the chemical interaction of the inhibitor with the metal surface.
Multi-detector CT angiographic imaging in the follow-up of patients after endovascular abdominal aortic aneurysm repair (EVAR)
Authors: Iezzi Roberto , Santoro M. , Dattesi R. , Pirro F. , Nestola M. , Spigonardo F. , Cotroneo A. R. , Bonomo L. 
Published: June 2012

Abstract
Background
Multidetector computed tomography (MDCT) angiography represents the standard of reference in the follow-up of patients after endovascular abdominal aortic aneurysm repair (EVAR), being effective in the detection of the full spectrum of possible complications on both axial and 3D images.

Methods
The purpose of this article is to review the normal CT angiography findings of the different types of stent-grafts and to describe the radiological findings of early and late complications after EVAR on axial and reconstructed images. A selection of cases of post-EVAR MDCT angiography is presented to learn the techniques most commonly used for endovascular treatment, the correct CT scanning technique to acquire the data, the full gamut of possible procedure-related complications and how these complications usually appear on CT images.

Conclusion
MDCT angiography is an effective and specific technique in both the pre- and postoperative settings of EVAR procedures. A better understanding of the procedure, the devices, the normal postoperative imaging features and the possible procedure-related complications ensures optimal planning and follow-up of patients undergoing an EVAR procedure.
Effects of sleep fragmentation on appetite and related hormone concentrations over 24 h in healthy men
Authors: Gonnissen Hanne K. J. , Hursel Rick , Rutters Femke , Martens Eveline A. P. , Westerterp-Plantenga Margriet S. 
Published: June 2012

In addition to short sleep duration, reduced sleep quality is also associated with appetite control. The present study examined the effect of sleep fragmentation, independent of sleep duration, on appetite profiles and 24 h profiles of hormones involved in energy balance regulation. A total of twelve healthy male subjects (age 23 (sd4) years, BMI 24·4 (sd1·9) kg/m2) completed a 24 h randomised crossover study in which sleep (23.30–07.30 hours) was either fragmented or non-fragmented. Polysomnography was used to determine rapid-eye movement (REM) sleep, slow-wave sleep (SWS) and total sleep time (TST). Blood samples were taken at baseline and continued hourly for the 24 h period to measure glucose, insulin, ghrelin, leptin, glucagon-like peptide 1 (GLP-1) and melatonin concentrations. In addition, salivary cortisol levels were measured. Visual analogue scales were used to score appetite-related feelings. Sleep fragmentation resulted in reduced REM sleep (69·4 min compared with 83·5 min;P< 0·05) and preservation of SWS without changes in TST. In fragmentedv.non-fragmented sleep, glucose concentrations did not change, while insulin secretion was decreased in the morning, and increased in the afternoon (P< 0·05), and GLP-1 concentrations and fullness scores were lower (P< 0·05). After dinner, desire-to-eat ratings were higher after fragmented sleep (P< 0·05). A single night of fragmented sleep, resulting in reduced REM sleep, induced a shift in insulin concentrations, from being lower in the morning and higher in the afternoon, while GLP-1 concentrations and fullness scores were decreased. These results may lead to increased food intake and snacking, thus contributing to a positive energy balance.