bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exponential Stability of an Improved Dual-Phase-Lag Model for Ultrafast Heating of Materials
Authors: Sachan Satyam , Kumar Roushan 
Published: June 2024

Abstract

The goal of this work is to demonstrate the exponential stability of a recently proposed thermoelastic theory called the improved dual-phase-lag (IDPL) model given by Zarei and Pilla (2023), precisely to address the encounters posed by fast and ultrafast heating of materials. In order to obtain it, we consider the one-dimensional problem of the theory of thermoelasticity with an IDPL model. Then, using the Routh-Hurwitz criterion, we prove that when τ0 < τ1, the solutions are obtained exponentially stable, and when τ0 < τ1, there exist unstable solutions.
Parent-led Communication Therapy for Young Bilingual Autistic Children: A Scoping Review
Authors: Oudet Sarah , Howard Katie , Gilhuber Christina , Robert Marie , Zimmerli Joanna , Katsos Napoleon , Durrleman Stephanie 
Published: June 2024

Abstract

Purpose: A scoping review of the literature was undertaken using JBI guidelines to map the evidence of parent-led therapy (PLT) for young autistic children (£6 years) raised in bilingual environments. Methods: Databases were searched on 11 January 2023 (Medline – EBSCO, PsychINFO, ERIC, Web of Science, and ProQuest Dissertations). Eligible papers included peer-reviewed and grey literature that was empirical in nature documenting PLT targeted to parents of young autistic children in bilingual environments. Reviewers used Covidence to screen titles and abstracts of located sources, and to screen full-text papers. Results Sixteen papers met inclusion criteria. A strong acceleration of reports of PLT for young autistic children measured in bilingual environments was observed, with 93.8% of papers (n = 15) published since 2015. A large majority of these studies, 87.5% (n = 14) were conducted in North America. Diverse PLT programs and methodologies were identified. Reporting of participants’ language environments was inconsistent. Five programs are identified to be publicly available as a clinical service. Conclusion PLT is a rapidly emerging approach to addressing complex issues at the intersection of autism, bilingualism, and service accessibility. Measuring the feasibility and effectiveness of PLT in bilingual environments is relatively novel in research. The synthesised results of this review alert researchers, clinicians, and the autism community, alike, to different types of service and different delivery options for families of young autistic children in bilingual environments, and the evidence gaps in the literature.
Cost-effective phosphates redox-neutral transformation to bench-stable phosphorylation precursor
Authors: Quan Zheng-Jun , Tian Yaling , Chen Dongping , Chai Yao , Li Ming , Wang Xi-Cun , Du Zhengyin , Wu Xiaofeng 
Published: June 2024

Abstract

Modern synthesis methods of organophosphorus heavily rely on white phosphorus and its
(oxy)chlorination reagents. Phosphates have the potential to serve as the perfect natural building blocks, forming the basis for organic and biochemical syntheses. However, poor solubility, high stability, and low reactivity make it challenging for transformation of phosphates to active reagents under mild conditions. Here we show an efficient conversion in which various phosphate sources are directly transformed into the [TBA][PO2X2] (X = Cl, F) phosphorylation reagents through a redox-neutral process by using cyanuric chloride and 1-formylpyrrolidine in the presence of a tetrabutylammonium chloride at ambient conditions. Key features of this conversion involve the utilization of cost-effective and readily available chemicals, circumventing the need of redox reactions with high-energy and forming a reactive yet stable P(V)-reagent. In comparison with the known phosphorylation precursor, [PO2X2]- salts are bench-stable, easy to handle, affording the phosphorylation compounds with before challenging substrates.
High-throughput RNA-Seq and In-silico analysis of glioblastoma cells treated with cold atmospheric plasma and temozolomide.
Authors: Soni Vikas , Dawson Tyson , Lin Li , Crandall Keith , Sherman Jonathan , Keidar Michael 
Published: June 2024

Abstract

Glioblastoma multiforme (GBM) is one of the most common and aggressive forms of malignant brain cancer in adults and is classified based on its isocitrate dehydrogenase (IDH) mutation. Surgery, radiotherapy, and Temozolomide (TMZ) are the standard treatment methods for GBM. Here we present a combination therapy of cold atmospheric plasma (CAP) and TMZ as a key treatment for GBM. CAP works by increasing reactive oxygen and nitrogen species (RONS) and targets the spread of the tumor. In this study, we performed the transcriptomic analysis of U-87MG cells by high throughput deep RNA-Seq analysis to quantify differential gene expression across the genome. Furthermore, we studied various signaling pathways and predicted structural changes of consequential proteins to elucidate the functional changes caused by up or down-regulation of the most altered genes. Our results demonstrate that combination treatment downregulated key genes like p53, histones, DNA damage markers, cyclins, in the following pathways: MAPK, P53, DNA damage and cell cycle. Moreover, in silico studies were conducted for further investigation to verify these results, and the combination of CAP & TMZ showed a significant antitumor effect in the GBM cells leading to apoptosis and damaged key proteins. Further studies of the impact of TMZ on gene expression, biochemical pathways, and protein structure will lead to improved treatment approaches for GBM.
A Microphysiological HHT-on-a-Chip Platform Recapitulates Patient Vascular Lesions
Authors: Hughes Christopher C.W. , Fang Jennifer , Hatch Christopher , Andrejecsk Jillian , Trigt William Van , Juat Damie , Chen Yu-Hsi , Matsumoto Satomi , Lee Abraham 
Published: June 2024

Abstract

Hereditary Hemorrhagic Telangiectasia (HHT) is a rare congenital disease in which fragile vascular malformations (VM) – including small telangiectasias and large arteriovenous malformations (AVMs) – focally develop in multiple organs. There are few treatment options and no cure for HHT. Most HHT patients are heterozygous for loss-of-function mutations affecting Endoglin (ENG) or Alk1 (ACVRL1); however, why loss of these genes manifests as VMs remains poorly understood. To complement ongoing work in animal models, we have developed a fully human, cell-based microphysiological model based on our Vascularized Micro-organ (VMO) platform (the HHT-VMO) that recapitulates HHT patient VMs. Using inducible ACVRL1 -knockdown, we control timing and extent of endogenous Alk1 expression in primary human endothelial cells (EC). Resulting HHT-VMO VMs develop over several days. Interestingly, in chimera experiments AVM-like lesions can be comprised of both Alk1-intact and Alk1-deficient EC, suggesting possible cell non-autonomous effects. Single cell RNA sequencing data are consistent with microvessel pruning/regression as contributing to AVM formation, while loss of PDGFB implicates mural cell recruitment. Finally, lesion formation is blocked by the VEGFR inhibitor pazopanib, mirroring positive effects of this drug in patients. In summary, we have developed a novel HHT-on-a-chip model that faithfully reproduces HHT patient lesions and that can be used to better understand HHT disease biology and identify potential new HHT drugs. Word Count: 213
Classification. Biological Sciences, Cell Biology
Navigating Ethical Frameworks to Mitigate Academic Misconduct While Leveraging Generative AI
Authors: Uddin Mohammad Mohi , Abu Stephen Emmanuel 
Published: June 2024

Abstract

The rapid advancement of Generative AI in academia raises ethical concerns about academic integrity. This study aims to delineate the key ethical concerns prevalent in academia and propose a theoretical framework that incorporates deontological ethics for learners and teleological ethics for evaluators. Employing a qualitative methodology and thematic analysis, this research undertakes a systematic scoping review of scholarly articles. The researcher searched various academic databases, following specific inclusion and exclusion criteria, and he selected a final set of 68 relevant studies out of 200 for review. The study found the lack of academic integrity, particularly in written assignments, due to the heightened risk of plagiarism, and to address them, the establishment of ethical guidelines was effective for learners' ethical awareness in using AI and inspiring educators to assess learners’ academic creation emphasizing learners’ own creativity. The study has the potential to inform the development of ethical guidelines for the use of AI in academia. As generative AI tools become increasingly prevalent, the risk of academic misconduct escalates, thereby threatening educational institutions' credibility and academic qualifications' integrity. The study will help to understand how ethical frameworks can mitigate the risk of plagiarism and foster a culture of ethical awareness among students and educators.
“In the USSR, Philately Will Either Be Accessible to the Masses or Will Not Exist at All”: The Genesis of Soviet Mass Collecting in the 1920s–1930s
Authors: Иванов А.С. 
Published: June 2024

В статье представлены результаты исследования дискурса коллекционирования в РСФСР/СССР в период 1922–1932 гг., развернувшегося на страницах тематических журналов. Источниковой базой работы стали журналы, выходившие в разных регионах страны. Особое внимание уделено установлению монополии на коллекционирование и деятельности основателей советского коллекционирования – уполномоченного Центральной Комиссии помощи голодающим при ВЦИК по филателии и бонам Ф.Г. Чучина и историка-византиниста М.Я. Сюзюмова. Изучение литературы по указанной теме позволило систематизировать историографию, а также предложить объяснительную модель советского коллекционирования, которое зиждилось на политическом (идеологическом), экономическом, социальном и культурном аспектах. Анализ литературы и источников позволяет сделать вывод, что легальное коллекционирование в этот период, во-первых, сужается до филателии и других форм собирательства, и, во-вторых, проходит путь от беспартийности и аполитичности к многофакторному вспомогательному средству воспитания советских граждан в рамках досуговых практик. Вопреки устоявшемуся в историографии тезису, массовое коллекционирование в СССР на этом этапе не прекращало своего существования, а стало распространенной детской досуговой практикой в созданных ранее институтах.
The article presents the results of the study of the discourse of collecting in the pages of thematic magazines in the RSFSR/USSR in the period between 1922 and 1932. The source base of the research includes magazines that were published in different regions of the country. Special attention is paid to the establishment of a monopoly on collecting and to the activities of the founders of Soviet collecting (F. Chuchin, Commissioner of the Central Commission for Famine Relief under the VTsIK on Philately and Notaphily, and M. Syuzyumov, an expert in Byzantine history). The study of literature on the topic made it possible to systematize historiography and to offer an explanatory model of Soviet collecting, which was based on political (ideological), economic, social, and cultural aspects. The analysis of literature and sources allows us to conclude that, firstly, legal collecting during that period narrowed down to philately and other forms of collecting, and secondly, from being non-partisan and apolitical, it evolved into a multifactorial auxiliary means of educating Soviet citizens within leisure practices. Contrary to the well-established in historiography thesis, mass collecting in the USSR did not cease to exist at that stage, but it became a widespread children’s leisure practice in the institutions that had been created earlier.
Vinblastine/prednisolone chemotherapy leads to hematological toxicity in dogs with high-grade or metastatic mast cell tumors
Authors: Soussa Ryan W. , Jaderberg Suzie , Williams Tim L. , Dobson Jane M. 
Published: June 2024

Abstract

OBJECTIVE
To determine the myelosuppressive effects/hematological toxicities, other general toxicities, and when these occur during vinblastine/prednisolone chemotherapy in dogs bearing high-grade or metastatic cutaneous/subcutaneous mast cell tumors (MCTs).

METHODS
Medical records were retrospectively reviewed between November 1, 2016, and March 1, 2023. Thirty client-owned dogs with histopathologically confirmed cutaneous high-grade MCTs/metastatic subcutaneous MCTs and that subsequently completed a 12-week vinblastine/prednisolone chemotherapy protocol were included. Hematology was assessed before commencing chemotherapy and before each vinblastine treatment. The effect of each treatment upon hematological values was evaluated. Measured outcomes included the type, frequency, and severity of hematological and other more general toxicities.

RESULTS
24 of 30 dogs experienced at least 1 hematological toxicity, 6 experienced gastrointestinal toxicity, and 4 experienced lethargy. The most common toxicity was anemia (15/30 [50%]), with 93.3% (14/15 dogs) classified as Veterinary Cooperative Oncology Group–Common Terminology Criteria for Adverse Events grade I and 6.6% (1/15) classified as grade II. The second most common toxicity was neutropenia (14/30 [46.6%]), with 71.4% (10/14) classified as grade I and 28.6% (4/14) as grade III. The least common hematological toxicity was thrombocytopenia (4/30 [13%]), all grade I. Neutropenia mainly occurred during weeks 2 and 3; however, there was no significant decrease in neutrophil count relative to baseline. Neutrophil count increased and Hct decreased during weeks 6 to 12 of treatment when compared to baseline. No change in platelet count was observed.

CLINICAL RELEVANCE
Vinblastine/prednisolone chemotherapy leads to hematological toxicity; however, this was mostly low-grade and did not require major intervention. Vinblastine/prednisolone chemotherapy is well tolerated in dogs bearing high-grade or metastatic MCTs.
Modeling Financial Risk Attitude: The Role of Education And Financial Literacy
Authors: Iannario Maria , Monti Anna Clara , Scalera Domenico 
Published: June 2024

Abstract
This paper studies the relationship between risk propensity, education and financial literacy. The results of the empirical investigation confirm the importance of the key explanatory variables of education and financial competence. Since they are both included in the model, the different roles of each are singled out. In particular, while education turns out to be a factor contributing to raising risk tolerance, financial literacy tends to reduce risk propensity. Risk attitude is evaluated by self-reported assessment and modeled through cumulative logit models. In order to handle anomalous data, M estimators with a bounded influence function are considered.
Impact of Institutions on Financial Inclusion in Africa
Authors: Łaszewski Antoni Ludwik 
Published: June 2024

Abstract
Financial inclusion, for which the keystone is access to a bank account, is crucial to overcome the socioeconomic backwardness of African countries and to improve the African societies’ well-being. The study concentrates on this continent to better understand the nature of its development in terms of financial inclusion. The research aims to identify the institutions’ impact on financial inclusion in 35 African countries in the years 2010-2019. The analysis is based on a panel model with fixed individual effects. Novelty of the study rests in incorporation of four institutional variables: constraints on the executive, resolving insolvency, property rights, and WGI. The results showed a positive and statistically significant impact of resolving insolvency on financial inclusion (a measure covering people with financial institution accounts) across the entire sample. However, this relationship is especially visible in more developed countries, while constraints on the executive turned out to be crucial for low-income countries. Another novelty of the study is creation of an index of financial inclusion covering Mobile Money which was used to verify the obtained results. In this case, no positive impact of any institutional variable was identified which may mean that a favourable institutional environment is not required for the development of Mobile Money.
The Change of the Monetary Paradigm: Financial Security and Cryptocurrency
Authors: Mihus Iryna , Marchenko Volodymyr , Dombrovska Alla , Panchenko Oksana 
Published: June 2024

Abstract
This study aims to investigate the economic characteristics of cryptocurrencies and assess the current legal framework regarding the potential to regulate transactions involving cryptocurrencies and other virtual assets. To achieve this goal, a complex set of general scientific and specialized research methods was applied, including comparative legal analysis, system-structural examination, generalization method, as well as methods of analysis and synthesis, DFD to build a model of the influence of cryptocurrency on the financial security of the state. As a result, we delved into the economic essence of blockchain-based cryptocurrencies as an alternative to traditional fiat currencies based on the principle of decentralization. It has been established that Bitcoin has a unique "hardness", due to which this cryptocurrency is rightly called «digital gold». The article analyzed the dynamics of the development of the use of blockchain technologies for 2009-2022, the results of which indicated the continuation of their annual growth in use. The article presents the results of a study on the introduction of cryptocurrency in Ukraine, which made it possible to systematize the main risks associated with it. In further research, it is possible to continue studying the economic-legal mechanism of the introduction of the national cryptocurrency in Ukraine and the use of blockchain in other financial processes at the state level.
Pile–Soil Interaction during Static Load Test
Authors: Siemaszko Paweł 
Published: June 2024

Abstract
This study highlights the possibility of determining the shear stress distribution along the skin of a pile, which represents skin resistance. Geotechnical engineering is plagued by the challenge of designing appropriate piles as a sufficient foundation construction while being economically justified solution. Static load testing facilitates verification if the pile satisfies these requirements. In most cases, the pile skin resistance is undervalued. This study first introduces the general approach based on static load test results using an appropriate mathematical approach in the presence of linear, vertical shear stress distribution boundary conditions as well as phenomena such as pile shortening and Kirchhoff's principle. Moreover, a scientific approach for pile compression and shear stress distribution is presented. Further, the study expands upon previous work by applying mathematical calculus to displacement piles. The promising results indicate that further work on greater number of piles may lead to a better understanding of pile–soil interaction and a more accurate design process.
Stromgestehungskosten von Erneuerbaren sind kein guter Indikator für zukünftige Stromkosten
Authors: Grimm Veronika , Oechsle Leon , Zöttl Gregor 
Published: June 2024

Abstract
The falling levelised cost of electricity (LCOE) of renewables is often used to argue that electricity costs in Germany will decline. However, the LCOE is not a reliable basis for estimating future electricity costs because gaps between demand and supply of insufficient renewable production will have to be covered by complementary technologies such as battery storage or gas-fired power plants and, in the future, hydrogen-fueled power plants. The investment costs of these plants and their operation must be included in the calculation of the costs of meeting demand. The “Levelised Cost of Load Coverage” (LCOLC) calculated in this way does not indicate that electricity costs will fall significantly in the coming decade.
Evidenzbasierte Forschung – die Irrelevanz des Manipulationsverdachts
Authors: Winkler Adalbert 
Published: June 2024

Abstract
On the occasion of the 80th birthday of Hayek‘s “The Road to Serfdom“, Veronika Grimm, Stefan Kolev and Jens Weidmann have drawn attention to the core messages of the book. In doing so, they relativise the accusation of ideology levelled at the book by instead being suspicious of the manipulation by evidence-based research as it may potentially contain hidden normative statements. This relativisation attempt is contradicted in the following article.
Arbeits- und Lebensbedingungen in Deutschland und den USA im Vergleich
Authors: Priewe Jan 
Published: June 2024

Abstract
A comparison of working and living conditions in the USA and Germany in 2022 shows that Germany performs better than the USA on a large number of indicators. Working and living conditions are measured on the basis of twelve dimensions using over 80 sub-indicators. For comparison: the traditional indicator “gross domestic product”, which is often used for international comparisons, was higher in the USA than in Germany in 2022. In the following, the alternative measurement of prosperity is presented and its results analysed.
Evaluasi Resiko Ergonomi Postur Pekerja Pencelupan Batik Menggunakan Rapid Upper Limb Assessment dan Quick Exposure Check di UKM Batik Pasha
Authors: Amalia Amalia , Jannah Vivin Noviatun 
Published: June 2024

ABSTRAKBatik pasha adalah salah satu UKM yang memproduksi berbagai kerajinan batik. Batik Pasha melakukan proses pencelupan secara manual yaitu menggunakan bak pencelupan dilantai dengan postur kerja yang jongkok atau membungkuk. Hal tersebut menyebabkan pekerja mengalami keluhan tubuh. Penelitian ini bertujuan untuk mengetahui bagian tubuh yang mengalami nyeri serta tingkat resiko postur kerja pada proses pencelupan di UKM Batik Pasha. Metode yang digunakan adalah Nordic Body Map (NBM), Rapid Upper Limb Assesment (RULA), dan Quick Exposure Check (QEC). Hasil pengukuran ergonomi pekerja mengalami keluhan pada beberapa bagian tubuh, serta final score metode Rapid Upper Limb Assesment (RULA) yaitu 7, dan Quick Exposure Check (QEC) level 3, hasil tersebut menunjukkan perlunya identifikasi dan perubahan segera. Tindakan perbaikan kerja yang dapat dilakukan adalah pekerja melakukan peregangan otot dan melakukan perubahan bentuk bak pencelupan yang sesuai dengan anthropometri. Kesimpulan dari penelitian ini adalah postur kerja stasiun pencelupan di UKM Batik Pasha dibutuhkan perubahan segera. Kata kunci: Pencelupan, Nordic Body Map (NBM), Rapid Upper Limb Assesment (RULA), Quick Exposure Check (QEC), Postur Kerja. ABSTRACTBatik pasha is one of the SMEs that produces various batik crafts. Batik Pasha does the dyeing process manually by using a dyeing bath on the floor with a squat or dyeing work posture. This causes workers to experience body complaints. This study aims to determine the parts of the body that are affected and the level of risk of work posture in the dyeing process at SME’s Batik Pasha. The methods used are Nordic Body Map (NBM), Rapid Upper Limb Assessment (RULA), and Quick Exposure Check (QEC). The results of the ergonomics measurement of workers experience complaints in several parts of the body, as well as the final score of the Rapid Upper Limb Assessment (RULA) method of 7, and the Quick Exposure Check (QEC) level 3, these results indicate the need for an immediate view and change. The work action that can be done is that the worker stretches the muscles and changes the shape of the immersion bath according to anthropometry. The conclusion of this study is that the work posture of the dyeing station at SME’s Batik Pasha needs immediate changes. Keyword: Dyeing, Nordic Body Map (NBM), Rapid Upper Limb Assesment (RULA), Quick Exposure Check (QEC), Work Posture