bluuebunny/crossref_metadata_2025_split huggingface dataset:
research paper: Differential expression of HDAC3, HDAC7 and HDAC9 is associated with prognosis and survival in childhood acute lymphoblastic leukaemia
Authors: Moreno Daniel Antunes , Scrideli Carlos Alberto , Cortez Maria Angélica Abdala , De Paula Queiroz Rosane , Valera Elvis Terci , Da Silva Silveira Vanessa , Yunes José Andres , Brandalise Silvia Regina , Tone Luiz Gonzaga 
Published: July 2010

SummaryAltered expression of histone deacetylases (HDACs) is a common feature in several human malignancies and may represent an interesting target for cancer treatment, including haematological malignancies. We evaluated the mRNA gene expression profile of 12 HDAC genes by quantitative real‐time polymerase chain reaction in 94 consecutive childhood acute lymphoblastic leukaemia (ALL) samples and its association with clinical/biological features and survival. ALL samples showed higher expression levels of HDAC2, HDAC3, HDAC8, HDAC6 and HDAC7 when compared to normal bone marrow samples. HDAC1 and HDAC4 showed high expression in T‐ALL and HDAC5 was highly expressed in B‐lineage ALL. Higher than median expression levels of HDAC3 were associated with a significantly lower 5‐year event‐free survival (EFS) in the overall group of patients (P = 0·03) and in T‐ALL patients (P = 0·01). HDAC7 and HADC9 expression levels higher than median were associated with a lower 5‐year EFS in the overall group (P = 0·04 and P = 0·003, respectively) and in B‐lineage CD10‐positive patients (P = 0·009 and P = 0·005, respectively). Our data suggest that higher expression of HDAC7 and HDAC9 is associated with poor prognosis in childhood ALL and could be promising therapeutic targets for the treatment of refractory childhood ALL.
Kinetics and cellular sources of cathelicidin during the course of experimental latent tuberculous infection and progressive pulmonary tuberculosis
Authors: Castañeda-Delgado J , Hernández-Pando R , Serrano C J , Aguilar-León D , León-Contreras J , Rivas-Santiago C , Méndez R , González-Curiel I , Enciso-Moreno A , Rivas-Santiago B 
Published: July 2010

Summary
In spite of advances in immunology on mycobacterial infection, there are few studies on the role of anti-microbial peptides in tuberculosis. The cathelin-related anti-microbial peptide (CRAMP) is the only cathelicidin isolated from mice. In this work we investigated the cellular sources and the production kinetics of this molecule during experimental tuberculosis, using two well-characterized models of latent or chronic infection and progressive disease. The lung of non-infected control mice expressed CRAMP at very low levels. In both models of experimental tuberculosis the main cells immunolabelled for CRAMP were bronchial epithelial cells, macrophages and pneumocytes types II and I. After intratracheal infection with a high bacilli dose (H37Rv strain) in Balb/c mice to produce progressive disease, a high CRAMP gene expression was induced showing three peaks: very early after 1 day of infection, at day 21 when the peak of protective immunity in this model is raised, and at day 28 when the progressive phase starts and the immunoelectronmicroscopy study showed intense immunolabelling in the cell wall and cytoplasm of intracellular bacilli, as well as in cytoplasmic vacuoles. Interestingly, at day 60 post-infection, when advanced progressive disease is well established, characterized by high bacillary loads and extensive tissue damage, CRAMP gene expression decreased but strong CRAMP immunostaining was detected in vacuolated macrophages filled with bacilli. Thus, cathelecidin is highly produced during experimental pulmonary tuberculosis from diverse cellular sources and could have significant participation in its pathogenesis.
Women’s perceptions and experiences of a traumatic birth: a meta‐ethnography
Authors: Elmir Rakime , Schmied Virginia , Wilkes Lesley , Jackson Debra 
Published: July 2010

elmir r., schmied v., wilkes l. & jackson d. (2010) Women’s perceptions and experiences of a traumatic birth: a meta‐ethnography. Journal of Advanced Nursing 66(10), 2142–2153.AbstractAim.  This study presents the findings a meta‐ethnographic study reporting women’s perceptions and experiences of traumatic birth.Background.  Childbirth is viewed by many as a life transition that can bring a sense of accomplishment. However, for some women, birth is experienced as a traumatic event with a minority experiencing post‐traumatic stress. A traumatic birth experience can have a significant impact on the physical and emotional well‐being of a woman, her infant and family.Data source.  The CINAHL, MEDLINE, Scopus and PubMed databases were searched for the period January 1994 to October 2009 using the keywords birth trauma, traumatic birth, qualitative research, birth narrative and birth stories.Review methods.  A meta‐ethnographic approach was used. Quality appraisal was carried out. An index paper served as a guide in identifying particular findings and comparing them with other findings. This ‘reciprocal translation’ process started with a search for common themes, phrases and metaphors.Results.  Ten qualitative studies were included in the final sample. Six major themes were identified: ‘feeling invisible and out of control’, ‘to be treated humanely’, ‘feeling trapped: the reoccurring nightmare of my childbirth experience’, ‘a rollercoaster of emotions’, ‘disrupted relationships’ and ‘strength of purpose: a way to succeed as a mother’.Conclusions.  It is evident that a small percentage of women experience a traumatic birth. Although some women who experience a traumatic birth do not necessarily have physical or psychological adverse outcomes, others identify a significant personal impact. Healthcare professionals must recognize women’s need to be involved in decision‐making and to be fully informed about all aspects of their labour and birth to increase their sense of control.
Collaborative recommendation of e‐learning resources: an experimental investigation
Authors: Manouselis N. , Vuorikari R. , Van Assche F. 
Published: July 2010

AbstractRepositories with educational resources can support the formation of online learning communities by providing a platform for collaboration. Users (e.g. teachers, tutors and learners) access repositories, search for interesting resources to access and use, and in many cases, also exchange experiences and opinions. A particular class of online services that take advantage of the collected knowledge and experience of users are collaborative filtering ones. The successful operation of such services in the context of real‐life applications requires careful testing and parameterization before their actual deployment. In this paper, the case of developing a learning resources' collaborative filtering service for an online community of teachers in Europe was examined. More specifically, a data set of evaluations of learning resources was collected from the teachers that use the European Schoolnet's learning resource portal. These evaluations were then used to support the experimental investigation of design choices for an online collaborative filtering service for the portal's learning resources. A candidate multi‐attribute utility collaborative filtering algorithm was appropriately parameterized and tested for this purpose. Results indicated that the development of such systems should be taking place considering the particularities of the actual communities that are to be served.
Adaptation provisioning with respect to learning styles in a Web‐based educational system: an experimental study
Authors: Popescu E. 
Published: July 2010

AbstractPersonalized instruction is seen as a desideratum of today's e‐learning systems. The focus of this paper is on those platforms that use learning styles as personalization criterion called learning style‐based adaptive educational systems. The paper presents an innovative approach based on an integrative set of learning preferences that alleviates some of the limitations of similar systems. The adaptive methods used as well as their implementation in a dedicated system (WELSA) are presented, together with a thorough evaluation of the approach. The results of the experimental study involving 64 undergraduate students show that accommodating learning styles in WELSA has a beneficial effect on the learning process.
Effect of unilateral endobronchial valve insertion on pulmonary ventilation and perfusion: A pilot study
Authors: CHUNG Steven C. S. , PETERS Matthew J. , CHEN Stephanie , EMMETT Louise , ING Alvin J. 
Published: July 2010

ABSTRACTBackground and objective:  The effects of bronchoscopic lung volume reduction (BLVR) on pulmonary ventilation and perfusion are incompletely understood. In this pilot trial, we investigated serial changes in regional ventilation and perfusion following unilateral endobronchial valve placement in COPD patients with heterogeneous emphysema.Methods:  At baseline and at days 30 and 90 following BLVR, subjects underwent lung function, 6MWD and St George's Respiratory Questionnaire. Ventilation and perfusion scintigraphy were performed to quantitate and serially compare regional differences.Results:  Six out of eight subjects completed the study; all had endobronchial valves targeting their left upper lobe. At day 90 post‐BLVR, there was a trend towards an increase in FEV1 and a mean reduction in St George's Respiratory Questionnaire score of nine units. In the targeted left upper zone there was reduced ventilation and perfusion. Ventilation and perfusion to the right lung; and specifically the right lower zone, significantly increased.Conclusions:  There appears to be redistribution of ventilation and perfusion to the contralateral lung following endobronchial valve placement. This may be of importance when assessing patients for unilateral BLVR. Selecting patients with heterogeneous disease is emphasized, taking into consideration not just comparison between upper and lower lobes, but between left and right lungs. A larger trial is currently underway, guided by these findings.
Full‐term interstitial retroperitoneal pregnancy with delivery of a healthy infant
Authors: Milićević Srboljub , Jovanović Dragoljub , Vilendečić Zoran , Ljubić Aleksandar , Božanović Tanja , Niketić Ljiljana 
Published: July 2010

AbstractImplantation in the interstitial part of the oviduct is frequently associated with severe fetal and maternal morbidity. We present a patient with primary interstitial and secondary retroperitoneal ectopic pregnancy. The suspicion of an ectopic pregnancy was raised after an ultrasound examination during the 18th week of pregnancy. An almost complete lack of symptoms led us to discard the possibility of an ectopic pregnancy. This normal‐course pregnancy advanced to term. Due to anhydramnios and fetal malpresentation, a laparotomy was performed at 39 weeks of pregnancy and a healthy infant was delivered via cesarean section.
Vascular endothelial growth factor, fms‐like tyrosine kinase‐1 (Flt‐1) and soluble Flt‐1 gene expressions in Korean pre‐eclamptic placentas
Authors: Park Jong‐Sik , Baik Haing‐Woon , Lee Seong‐Kyu , Na Woo‐Suk , Song Young‐Rae , Yang Yun‐Suk , Park Mi‐Hae , Hwang In‐Taek , Park Joon‐Sook , Oh Kwan‐Young 
Published: July 2010

AbstractAim:  To assess the expressions of vascular endothelial growth factor (VEGF), fms‐like tyrosine kinase‐1 (Flt‐1), and soluble Flt‐1 (sFlt‐1) genes in healthy normotensive and pre‐eclamptic placentas of Korean women.Methods:  We investigated 12 healthy normotensive pregnant women and 10 pre‐eclamptic pregnant women at Eulji University Hospital. The obtained placental tissues were analyzed using reverse transcription polymerase chain reaction and real‐time quantitative polymerase chain reaction.Results:  The sFlt‐1 messenger ribonucleic acid (mRNA) level was elevated 2.6 times more in pre‐eclamptic placentas than in normal control placentas. However, the VEGF mRNA level of pre‐eclamptic placentas was decreased. There was no difference in the Flt‐1 mRNA level between control and pre‐eclamptic placentas.Conclusions:  Our study showed that expressions of genes relating to angiogenesis were altered in Korean pre‐eclamptic placentas. These results suggest that the alteration in expressions of sFlt‐1 and VEGF genes might be associated with the pathogenesis of pre‐eclampsia.
Neuronal localization of the mitochondrial protein NIPSNAP1 in rat nervous system
Authors: Nautiyal Manisha , Sweatt Andrew J. , MacKenzie James A. , Mark Payne R. , Szucs Sylvia , Matalon Reuben , Wallin Reidar , Hutson Susan M. 
Published: July 2010

AbstractThe NIPSNAP (4‐nitrophenylphosphatase domain and non‐neuronal SNAP25‐like protein homolog 1) proteins belong to a highly conserved family of proteins of unknown function. We found that NIPSNAP1 binds to the branched‐chain α‐keto acid (BCKA) dehydrogenase enzyme complex, which is disrupted in maple syrup urine disease, a disease of branched‐chain amino acid catabolism that results in neurological dysfunction. Phenylketonuric (PKU) and epileptic mice show altered expression of NIPSNAP1 in the brain. Therefore, the distribution and localization of NIPSNAP1 in rat brain was determined. Results show that NIPSNAP1 is expressed exclusively in neurons including pyramidal neurons in the cerebral cortex, Purkinje neurons in the cerebellum and motor neurons in the spinal cord. Dopaminergic neurons in midbrain and noradrenergic neurons in the brainstem, which are affected in PKU, also express NIPSNAP1. NIPSNAP1 is found to be localized in the mitochondrial matrix and can bind dihydrolipoyl‐transacylase and ‐transacetylase components of the BCKA and pyruvate dehydrogenase complexes in vitro. Our data provide the first experimental evidence for a strictly neuronal expression of this mitochondrial protein in the rat nervous system.
Immigration and Outsourcing: A General‐Equilibrium Analysis
Authors: Bandyopadhyay Subhayu , Wall Howard J. 
Published: July 2010

AbstractThis paper analyzes immigration and outsourcing in a general‐equilibrium model of international factor mobility. In our model, legal immigration of skilled labor is controlled through a quota, while outsourcing is determined both by the firms in response to market conditions and through policy‐imposed barriers. A loosening of the immigration quota reduces outsourcing, enriches capitalists, leads to losses for native workers, and raises national income. If the nation targets an exogenously determined immigration level, the second‐best outsourcing tax can be either positive or negative. If in addition to the immigration target there is a wage target arising out of income distribution concerns, an outsourcing subsidy is required. We extend the analysis to consider illegal immigration of unskilled labor. A higher legal immigration quota will lead to more (less) illegal immigration if skilled and unskilled labor are complements (substitutes) in production.
FDI Flows to Latin America, East and Southeast Asia, and China: Substitutes or Complements?
Authors: Chantasasawat Busakorn , Fung K. C. , Iizaka Hitomi , Siu Alan 
Published: July 2010

AbstractIs China diverting foreign direct investment (FDI) from other developing countries? Theoretically, a growing China augments other countries' FDI by creating more production networking and raising demand for resources. However, low Chinese costs lure multinationals away from other production sites. Here we explore this issue empirically. We focus on East and Southeast Asia and Latin America for 1985–2002. We control for the standard determinants of inward FDI, then add China FDI to represent the “China Effect.” We found that China's FDI is positively related to FDI in Asia, while the China Effect is insignificant for Latin America. Also the China Effect is generally not the most important determinant of other countries' FDI. Market sizes and policies such as corporate tax rates and openness tend to be more important.
Negotiating fair pay and conditions: low paid women's experience and perceptions of labour market deregulation and individual wage bargaining
Authors: Jefferson Therese , Preston Alison 
Published: July 2010

ABSTRACTThe OECD is strongly supportive of the industrial relations changes recently introduced in Australia. This article examines the experiences of low paid women in a deregulated labour market context. The research highlights the gendered effects of the recent reforms and cautions against the use of Australia as a model framework.
Origin and flux of a gas seep in the Northern Alps (Giswil, Switzerland)
Authors: ETIOPE G. , ZWAHLEN C. , ANSELMETTI F. S. , KIPFER R. , SCHUBERT C. J. 
Published: July 2010

AbstractNatural gas seeps in the Alpine region are poorly investigated. However, they can provide useful information regarding the hydrocarbon potential of sedimentary Alpine units and related geofluid migration, typically controlled by pressurized gas accumulations and tectonics. A gas seep located near Giswil, in the Swiss Northern Alps, was investigated, for the first time, for molecular and isotopic gas composition, methane flux to the atmosphere, and gas flux variations over time. The analyses indicated that the gas was thermogenic (CH4 > 96%; δ13C1: −35.5‰ to −40.2‰) and showed evidence of subsurface petroleum biodegradation (13C‐enriched CO2, and very low C3+ concentrations). The source rock in the region is marine Type II kerogen, which is likely the same as that providing thermogenic gas in the nearby Wilen shallow well, close to Lake Sarnen. However, the lack of δ13CCO2 and δ13C3 data for that well prevented us from determining whether the Wilen and Giswil seeps are fed by the same reservoir and seepage system. Gas fluxes from the Giswil seep, measured using a closed‐chamber system, were significant and mainly from two major vents. However, a substantial gas exhalation from the soil occurs diffusely in an area of at least 115 m2, leading to a total CH4 output conservatively estimated to be at least 16 tonnes per year. Gas flux variations, monitored over a 1‐month period by a special tent and flowmeter, showed not only daily meteorological oscillations, but also an intrinsic ‘pulsation’ with periods of enhanced flux that lasted 2–6 h each, occurring every few days. The pulses are likely related to episodes of gas pressure build‐up and discharge along the seepage system. However, to date, no relationship to seismicity in the active Sarnen strike‐slip fault system has been established.
Cognitive Impairment in New Cases of Epilepsy Randomly Assigned to Carbamazepine, Phenytoin and Sodium Valproate
Authors: Forsythe Ian , Butler Richard , Berg Ian , McGuire Ralph 
Published: July 2010

SUMMARYSixty‐four new cases of childhood epilepsy were randomly assigned to either carbamazepine, phenytoin or sodium valproate, and were assessed with cognitive tests before medication and three subsequent times over a year. Carbamazepine in moderate dosage adversely affected memory, but sodium valproate and phenytoin did not.RÉSUMÉAltérations cognitives dans les nouveaux cas d'épilepsie traités au hasard par la carbamazépine, la phénytoine et le valproate de sodiumSoixante‐quatre nouveaux cas d'épilepsie de I'enfance ont été orientés au hasard vers un traitement par carbamazépine, phénytoine ou valproate de sodium et furent, évalués par des tests cognitifs avant le début de la médication et ultérieurement trois fois au cours d'une année. La carbamazépine à doses modérées altérait le mémoire, mais le valproate de sodium et la phénytoine ne le faisaient pas.ZUSAMMENFASSUNGKognifive Störungen bei neuen Epilepsiefällen, die wahllos mit Carbamazepin, Phenytoin oder Valproinsäure behandelt worden waren.64 Neue Fälle mit kindlicher Epilepsie wurden willkürlich entweder mit Carbamazepin, Phenytoin oder Valproinsäure behandelt und vor der Therapie, sowie dreimal danach irn Verlauf eines Jahres, mit kognitiven Tests untersucht. Carbamazepin hatte in mäßiger Dosierung einen negativen Effekt auf das Gedächtnis, Valproinsäure und Phenytoin nicht.RESUMENAlteración cognitiva en casos nuevos de epilepsia tratados al azar con carbatnazepina, fenitoína y valproato sódicoSesenta y cuatro casos de epilepsia infantil fueron tratados al azar con carbamazepina, fenitoina y valproato sódico y fueron examinados con tests cognitivos antes de la medicación y tres veces más en el curso de un año. La carbamazepina a dosis moderadas afectaba adversamente a la memoria, cosa que no hacían ni el valproato ni la fenitoína.
Left Unilateral Neglect in a Preschool Child
Authors: Thompson Nora M. , Ewing‐Cobbs Linda , Fletcher Jack M. , Miner Michael E. , Levin Harvey S. 
Published: July 2010

SUMMARYThe authors present a case of transient left hemispatial inattention following traumatic brain injury in a three‐year‐old child. Computed tomographic scan revealed a small right frontal and a right temporo‐parietal contusion. Stimuli were developed to quantify the response difference between hemifields in this pre‐literate child. Hemispatial inattention showed resolution at 19 days post‐trauma and had completely resolved six months later. These findings suggest that right hemisphere systems subserve visually guided attention before six years of age.RÉSUMÉNégligence gauche unilatérale chez un enfant d'âge préscolaireLes auteurs rapportent le cas d'une inattention hémispatiale gauche transitoire à la suite d'une lésion cérébrale chez un enfant de trois ans. Les scanner révéla une petite contusion frontale droite et une contusion temporo‐pariétale droite. Des stimulations furent provoquées pour quantifier les différences de réponses entre les deux hémi‐champs chez cet enfant de capacité pré‐scolaire. L'inattention hémispatiale s'atténua 19 jours après le traumatisme et disparut complètement six mois plus tard. Ces données suggèrent que les systèmes hémisphériques droits participent à l'attention sous contrôle visuel avant l'âge de six ans.ZUSAMMENFASSUNGLinksseitige laterale Aufmerksamkeitsstörung bei einem VorschulkindDie Autoren stellen ein dreijähriges Kind vor, das nach einem Hirntrauma eine passagere räumliche Aufmerksamkeitsstörung links aufwies. Im Computertomogramm zeigten sich rechts frontal und rechts temporoparietal kleine Contusionsherde. Es wurden Stimuli entwickelt, um die Wahrnehungsunterschiede der zwei Sehfeldabschnitte bei diesem Vorschulkind zu quantifizieren. Die räumliche Aufmerksamkeitsstörung begann sich am 19 posttraumatischen Tag zurückzubilden und war sechs Monate später vollständig verschwunden. Diese Befunde deuten darauf hin, daß die visuell gelenkte Aufmerksamkeit vor dem sechsten Lebensjahr von der rechten Hemisphäre gesteuert wird.RESUMENNegligencia unilateral izquierda en el preescolarLos autores presentan un caso de inatención transitoria hemiespacial izquierda después de una lesión traumática del cerebro en un niño de tres años de edad. La TAC reveló una pequeña contusión frontal y temporoparietal del lado izquierdo. Se aplicaron estímulos para cuantificar la diferencia de respuestas entre ambos hemisferios en este niño prelectivo. La inatención hemiespacial empezó a resolverse a los 19 dias después del trauma habiendo desaparecido totalmente seis meses más tarde. Estos hallazgos sugieren que los sistemas del hemisferio derecho subsirven la atención guiada visualmente antes de los seis años de edad.