bluuebunny/crossref_metadata_2025_split huggingface dataset:
Las emociones del lugar: de los afectos de Baruch Spinoza a la topofilia de Yi-Fu Tuan
Authors: Rojas López José 
Published: May 2024

La emergencia de la geografía humanista renovó un inusitado interés por las relaciones del mundo interior del sujeto con el lugar de su residencia o pertenencia. El tradicional lugar geográfico es ahora visto, desde una perspectiva fenomenológica, como espacio vivido, de identidad y significado para los individuos que lo habitan y lo hacen suyo. ¿Es posible establecer una relación entre la teoría de los afectos de Baruch Spinoza y el concepto de topofilia de Yi-fu Tuan? La búsqueda de respuesta es el tema de esta nota, a través de una lectura de la Etica de Spinoza y la Topofilia de Tuan, lo que permitió un acercamiento fenomenológico al lugar desde las “geografías afectivas”.
Analysis of benzimidazole anthelmintic resistance in parasitic nematodes <i>Haemonchus contortus</i> using nested isothermal amplification (PCR)
Authors: Pimenov I. A. , Varlamova A. I. , Afanasyev A. D. , Odoevskaya I. M. 
Published: May 2024

The purpose of the research is to monitor farms located in the European part of the Russian Federation to identify resistance to effects of benzimidazole anthelmintics in populations of nematodes Haemonchus contortus dwelling in the gastrointestinal tract of small cattle.Materials and methods. The studies were conducted in slaughterhouses located in the Moscow Region in 2023–2024. At the first stage, taxonomic identification of parasitic nematodes and larvae (L3) was made, and Strongylata species was determined from sheep. The study material was the abomasum with duodenum fragments and a distal rectum fragment with feces. For molecular studies, we used mature nematodes and H. contortus L3 larvae isolated from the abomasum and feces of small cattle brought to slaughterhouses in the Moscow Region from 8 regions of the European part of the Russian Federation: Moscow, Astrakhan, Oryol, Lipetsk, Tula, Bryansk regions, Stavropol and Dagestan. The studies were conducted at the premises of the Laboratory of Molecular Biology, the VNIIP – FSC VIEV. Statistical processing of the obtained data was made, and mean infection rates of parasitic nematodes (infection intensity and prevalence) were determined. Fifty-six DNA samples of nematodes H. contortus were examined using nested isothermal amplification (PCR) to identify gene alleles that determine resistance to benzimidazole drugs.Results and discussion. Molecular genetic studies of H. contortus DNA sampled from sheep brought from different Regions only detected homozygous individuals (100%) resistant to benzimidazole in the parasitic nematode population from the Oryol Region. Other regions identified only homozygous and heterozygous individuals susceptible to benzimidazole.
Clinical Care Pathway Time Intervals and Tumor Progression Among Head and Neck Cancer Patients at East Avenue Medical Center Before and During the COVID-19 Pandemic
Authors: Rafanan Fery Mai , Alfanta Eduard , Instrella Romulus Roberto Peter 
Published: May 2024

Objective: To investigate the association between the time intervals of key clinical time points and tumor progression (increase in clinical staging) in head and neck cancer patients before and during the pandemic.
Methods:
Design: Retrospective Cohort Study
Setting: Tertiary Government Training Hospital
Participants: A total of 81 head and neck cancer patients who consulted at the OPD and underwent elective surgery between January 1, 2018, and December 31, 2022, under the Department of Otorhinolaryngology – Head and Neck Surgery of East Avenue Medical Center were included in the study; 40 patients comprised the pre-pandemic group and 41 patients-the pandemic group.
Results:Majority of patients were men (61.73%), and the mean age was 54 years. The most prevalent tumor site was the oral cavity (37.04%). Most patients were Clinical Stage IV at the time of diagnosis (32.10%) and at the time of surgery (58.02%). In the pre-pandemic period, median time-to-consult was 180 days, time-to-diagnosis was 14 days, and time-to-treatment was 57 days. During the pandemic, median time-to-consult significantly increased to 365 days (Mann-Whitney test, U = 589, p = .028), but time-to-diagnosis decreased to 10 days, and time to-treatment decreased to 43 days, although these were not significant (U = 775, p = .667; U = 809, p = .917). Among the 81 patients in the study, 14 (17.28%) showed tumor progression (pre-pandemic: 6; 15%; pandemic: 8; 19.51%), but there was no significant association between time-to-consult and increase in clinical staging for both pre-pandemic (χ2(38) = 34.2, p = .646) and pandemic groups (χ2(16) = 23.1, p = .110) or between time-to-diagnosis and increase in clinical staging for pre-pandemic (χ2(56) = 36.8, p = .978) and pandemic groups (χ2(23) = 28.3, p = .267). Overall, there was no significant association between time-to-treatment and increase in clinical staging for both pre-pandemic (χ2(62) = 80.00, p = .062) and pandemic groups (χ2(32) = 30.4, p = .548), but a subset of patients with larynx primary tumor site had a statistically significant association between time-to-treatment and tumor progression (χ2(5) = 12.00, p = .035).
Conclusion:This study revealed that there was an increase in time to-consult for head and neck cancer patients during the pandemic. However, there was no significant difference in time-to-diagnosis and time-to-treatment. This shows that the Department of ORL-HNS, East Avenue Medical Center has provided pandemic head and neck cancer care similar to before the pandemic. No significant associations were found between tumor progression and time intervals of the key clinical time points but patients who had an increase in clinical stage were noted with longer time-to treatment. It was also observed that more patients were in advanced clinical stages during the pandemic.
Masalah dan Tantangan Desa Wisata Pasca Pandemi Covid-19
Authors: Santika Ismawati Zulfa , Wibowo Agung , Lestari Eny 
Published: May 2024

Pasca pandemi Covid-19 berpengaruh pada semakin banyaknya objek wisata yang kembali dibuka. Pembangunan dan pengelolaan potensi wisata daerah pasca pandemi perlu dilakukan melalui penentuan strategi yang tepat guna meningkatkan daya tarik wisatawan untuk berkunjung. Penelitian ini bertujuan untuk mengetahui pembangunan Embung Pengantin pasca pandemi Covid-19. Metode penelitian yang digunakan dalam penelitian ini berupa pendekatan kualitatif studi kasus. Metode pengumpulan data berupa wawancara mendalam (in depth interview), observasi, dan dokumentasi. Berdasarkan hasil penelitian yang telah dilakukan maka diperoleh kesimpulan bahwa pembangunan potensi wisata Embung Pengantin pasca pandemi Covid-19 berjalan kurang baik karena adanya masalah dan tantangan pada beberapa aspek sehingga mengakibatkan kesulitan bagi masyarakat pengelola dalam melakukan pembangunan wisata Embung Pengantin. Diperlukan strategi atau upaya khusus yang harus dilakukan oleh seluruh pemangku kepentingan guna mencapai keberhasilan dan keberlanjutan pembangunan wisata Embung sehingga nantinya dapat mendorong kembali peningkatan minat wisatawan untuk berkunjung.
Dairy product enriched with triple manganese complex
Authors: Blinov A. V. , Rekhman Z. A. , Gvozdenko A. A. , Golik A. B. , Nagdalуan A. A. , Rebezov M. B. 
Published: May 2024

Micronutrient deficiency is a serious problem in Russia. In this article, we developed a complex of the essential microelement manganese with ascorbic acid and L-isoleucine. The properties of the resulting compound were studied by X-ray phase analysis, IR spectroscopy, and computer quantum chemical modeling. It was established that the complex has an amorphous structure. As a result of the simulation, the optimal interaction model was determined: through the carboxyl group and α-amino group of L-isoleucine, and through the C2 and C3 atoms of ascorbic acid ( E = -2264.757 kcal/mol). Quantum chemical modeling data were confirmed by IR spectroscopy. The stability of the complex was studied under various technological parameters (pH, temperature and exposure time). To do this, a multifactorial experiment was carried out with three input parameters and three levels of variation. It has been shown that the stability of the ternary complex of the essential microelement manganese with ascorbic acid and the essential amino acid L-isoleucine is significantly influenced by all parameters (pH, temperature and exposure time). It was found that with increasing pH, temperature and exposure time, ∆ Eh increases, which indicates a loss of stability of the complex and its destruction. The parameters at which the stability of the samples is observed correspond to the lowest values of ∆ Eh: pH = 3–7, t = 25–60°, τ = 5–15. At the next stage, milk was enriched with the resulting compound at the rate of 30% of the daily dose of manganese consumption and studied the physicochemical parameters of milk depending on the concentration of the developed complex. It was found that for the enrichment of manganese ascorbate isoleucinate it is necessary to use concentrations of 0.005 mol/l or less, since the obtained indicators correspond to the quality standards established in the Russian Federation. According to the organoleptic assessment, the values of the indicators (smell and taste) of milk enriched with manganese ascorbate isoleucinate exceed the values of the indicators of the control sample (JSC MKS, Stavropol, Russia) and the sample enriched with the inorganic form of iron — manganese sulfate.
A scientifically-based approach to the prevention and treatment of cow mastitis with complex immunotropic drugs
Authors: Semenov V. G. , Tyurin V. G. , Musaev F. A. , Morozova N. I. , Luzova A. V. , Biryukova D. E. 
Published: May 2024

Relevance. Mastitis of cattle should be considered as one of the most important and serious problems in dairy cattle breeding. Antibiotic therapy is traditionally considered the most effective method of treatment, however, despite the observed therapeutic effect, relapses often occur. Therefore, the search for new methods of treatment and prevention of mastitis is extremely relevant.Methods. The objects of research were black-and-white cows. In the first series of tests, according to the principle of analog groups, four groups of cows of 10 heads were selected: one control and three experimental, in the second series – three experimental groups of 15 heads. In the first series of experiments, we carried out the prevention of cow mastitis using the immunotropic drugs “Prevention-N-A-M” and “Prevention-N-B-S” developed in the Chuvash State Agrarian University, as well as the drug “Mastinol” used on the farm. The drugs were applied to animals of the experimental groups at a dose of 10 ml 45–40, 25–20, 15–10 days before calving, in the control group the drugs were not used. In the second series of experiments, mastitis therapy was carried out according to the following scheme: in the 1st experimental group, “Prevention-N-A-M” was administered to animals, in the 2nd experimental group “Prevention-N-B-S” 40 ml every 24 hours, in the 3rd experimental group “Amoxicillin” 40 ml twice with 48 hours apart.Results. It has been established that immunotropic drugs contribute to the prevention and treatment of cow mastitis, improve hematopoiesis, metabolism, activate factors of nonspecific resistance, reproductive and productive qualities of the body, with a more pronounced — “Prevention-N-A-M” effect.
The productivity of spring wheat and the content of certain groups of microorganisms in the soil depend on nanopreparations
Authors: Zinkovskaya T. S. , Rabinovich G. Yu. , Podolyan E. A. 
Published: May 2024

Relevance. An important factor in reducing the dependence of crop productivity on various limiting factors is the use of fertilizers and biological products, which include nano-preparations. The work studied the effect of nano-preparations on the productivity of spring wheat and individual microbiological indicators of sod-podzolic light loamy soil when regulating the water-air regime.Methods. The research was carried out at the Gubino agro-testing site (Tver region) on soddy-podzolic light loamy drained soil. When the humidity in the 0–50 cm layer decreased below 70% of the PPV, the water regime was regulated by irrigation. Nanopreparations fulvohumate “Ivan Ovsinsky” and n-BoGum were used by spraying spring wheat plants of the Irgina variety. Nanopreparations were studied both separately and against the background of organic fertilizer — multi-purpose compost at a dose of 10 t/ha. Determination of individual groups of microorganisms in the soil was carried out using generally accepted methods in microbiology.Results. During the three-year experiment, a significant increase (significance of differences p < 0.05) in the yield of spring wheat was obtained in the variants with nanopreparations relative to the control. Their use against the background of multi-purpose compost when regulating the water-air regime gave the highest wheat productivity in all years of research. The effect of both nanopreparations was almost the same. The yield increase from nanopreparations relative to multi-purpose compost over an average of three years was 18–20% for irrigation and 11–13% for non-irrigation options and amounted to 3.58 t/ha and 2.83 t/ha respectively. When regulating the water regime, the content of ammonifying and phosphate-mobilizing microorganisms increased, associated with optimal hydration for their vital functions. This was especially evident during the dry period, when irrigation was carried out. The largest number of studied microorganisms was observed in the variants of multi-purpose compost + nanopreparations and with the addition of only multi-purpose compost. At the same time, a high connection with productivity was noted.
Faecal Immunochemical Test (FIT) Sensitivity; A Five Year Audit
Authors: Cole Eddie , Narayanan Deepa , Tiam Ree Nee , Shepherd John , Hajjawi Mark O. R. 
Published: May 2024

Introduction: Colorectal cancer has a high prevalence and mortality rate in the United Kingdom. Cancerous colorectal lesions often bleed into the gastrointestinal lumen. The faecal immunochemical test (FIT) detects haemoglobin (Hb) in the faeces of patients and is used as a first line test in the diagnosis of colorectal cancer.Materials and Methods: A retrospective audit of all FIT performed and all colorectal cancers diagnosed in the Hull and East Riding of Yorkshire counties of the United Kingdom (population approximately 609,300) between 2018 and 2022 was conducted. FIT were performed using a HM-JACKarc analyser from Kyowa medical. The predominant symptom suggestive of colorectal cancer which prompted the FIT was recorded. Colorectal cancer was diagnosed using the gold standard of histological biopsy following colonoscopy.Results: Between 2018 and 2022, 56,202 FIT were performed on symptomatic patients. Follow on testing identified 1,511 with colorectal cancer. Of these people, only 450 people with a confirmed colorectal cancer had a FIT within the 12 months preceding their diagnosis. Of these 450 FIT results, 36 had a concentration of &lt;10 μg/g and may be considered to be a false negative. The sensitivity of FIT in the patients identified was 92.00%. The most common reason stated by the clinician for a FIT being performed in patients with colorectal cancer was a change in bowel habits, followed by iron deficient anaemia. The number of patients diagnosed with colorectal cancer decreased in 2020, but increased significantly in 2021.Discussion: This study shows that 8.00% of people diagnosed with colorectal cancer in the Hull and East Riding of Yorkshire regions had a negative FIT. This study also shows that the SARS-CoV-2 pandemic affected the number of people diagnosed with colorectal cancer, and therefore skews the prevalence and pre-test probability of a positive test. There are many reasons why a FIT could produce a false negative result, the most likely being biological factors affecting the stability of haemoglobin within the gastrointestinal tract, or pre-analytical factors influencing faecal sampling preventing the detection of haemoglobin. Some colorectal lesions do not protrude into the gastrointestinal lumen and are less likely to bleed.Conclusion: This is the first study showing data from outside of a structured clinical trial and provides the largest study to date showing the sensitivity of FIT in a routine clinical setting. This study also provides evidence for the impact COVID-19 had on the rate of colorectal cancer diagnosis.
RESPUESTA A LA SEQUIA DE UN HIBRIDO DE MAIZ Y SU GENERACION F4
Authors: Peña Ramos Alfonso , Del Campo Valle Salvador Martín , Zapata Altamirano Ricardo J. 
Published: May 2024

El H-24 es un híbrido de maíz (Zea mays L.) de excelente comportamiento bajo temporales deficientes, pero ha sido poco usado debido a su alto costo de producción de semilla. Recientemente se derivó de este híbrido una generación F4 con la finalidadde tener una variedad de polinización Libre de mas fácil multiplicación. El objetivo del presente trabajo fue determinar si ambos maíces presentan respuestas similares bajo sequía. El estudio se realizó en Aguascalientes, bajo invernadero en macetas que contenían 19 kg de suelo seco. Se utilizó como testigo la variedad VS-201. Se establecieron tres tratamientos de humedad: R 0: Riego, R .= 15 días. sin riego durante. la floracion y R 2; 15 días sin riego durante el inicio del llenado de grano. cada tratamientoinvolucró 12 plantas de cada variedad. Se encontró que el híbrido y su generación F 4 tuvieron respuestas similares a la sequía en las dos etapas de desarrollo estudiadas. En R 1 se afectaron en menor grado que el testigo VS·201: perdieron menos área foliar; emergieron sus estigmas más temprano; dismirtuyeron menos tanto el rendimiento de grano (37% en promedio comparado con 72% del testigo) comom el peso seco total (66 g pl en promedio contra 138 g pl- del testigo) y no se afectaron en su índice de cosecha cuando en el testigo disminuyó 56%. En el tratamiento R2, los tres materiales se afectaron igual en todos los aspectos estudiados. Dentro de tratamientos, la generación F4 mostró una depresión promedio en el rendimiento del 11% respecto a su F1
APORTAClONES AL ESTUDIO DE LA DIVERSIDAD DE MAIZ DE LAS PARTES ALTAS DE MEXICO
Authors: Ortega-Paczka Rafael , Sánchez-González Jesús 
Published: May 2024

Como parte de un proyecto para el análisis de la diversidad de maíz (Zea mays L.) de México, se estudió la variación presente en las partes altas -arriba de 1850 msnm- del centro y norte del país, con el objeto de precisar mejor las razas existentes en estas áreas, las relaciones de similitud entre ellas y sus colectas representativas. En 1975 se inició la inspección de aproximadamente 2000 colectas, de las cuales se eligieron 35 que se consideraron representativas del conjunto; las 35 muestras se sembraron en Chapingo, Méx. en 1978 y se describieron con cierto detalle. Los datos obtenidos se analizaron con técnicas de taxonomía numérica. En general, los resultados confirmaron los obtenidos en estudios previos, tanto a nivel de razas como de complejos (grupos) raciales. Se definieron las colectas más adecuadas para representar a las razas Palomero Toluqueño, Cacahuacintle, Cónico, Cónico Norteño, Chalqueño, Bolita, Arrocillo Amarillo, Apachito y Palomero de Chihuahua. Las colectas estudiadas de Cristalino de Chihuahua, Gordo y Azul mostraron niveles altos de sisimilitud entre sí, sugieriendo que pueden representar el mismo germoplasma básico y debieran considerarse como una misma raza. En cuanto a grupos raciales, se forma uno integrado por las formas provenientesde la Alta Babícora, otro por Cacahuacintle y Elotes Cónicos y un tercero con el resto.
AS CONSTELAÇÕES SISTÊMICAS COMO FERRAMENTA PARA A SOLUÇÃO DE CONFLITOS ENVOLVENDO A CRIANÇA E ADOLESCENTE
Authors: Calegari Rosa Inaiara , Lopes da Silva Francisco , Mendonça Dias Camila , Luiz Alves Ricardo 
Published: May 2024

Resumo: Este estudo traz em seu contexto um método inovador, baseado nas técnicas da filosofia de vida do alemão Bert Hellinger. Essa ciência faz junção da filosofia com a psicologia e as normas jurídicas que direcionam a aplicabilidade da lei em nosso ordenamento jurídico. Nos últimos períodos a mesma teve grande crescimento, conhecida por constelação familiar está inclusa dentro do direito sistêmico. O Código Processo Civil atual traz em seu teor a grande importância das partes se conciliarem entre si, desse modo foi observado que seria um método judicial de extrema importância para resolução dos conflitos, haja vista, que as modalidades atualmente utilizadas pelos juristas não estavam sendo satisfatórias e suficientes para atender a todas as demandas. Nesse sentido, o objetivo do presente estudo é demonstrar a eficácia das Constelações Sistêmicas como ferramenta para a solução de conflitos familiares que envolvam crianças e adolescentes. Para tanto, será utilizada a metodologia qualitativa exploratória, por meio da consulta em materiais já produzidos em livros e artigos científicos sobre o assunto. Consignou-se que, o procedimento proporciona harmonia entre as partes envolvidas no litígio, quando é utilizado do meio convencional para obter resolução ao conflito no processo sempre temos deferimento ou indeferimento dos pedidos arrolados na petição, alguns são providos em sua totalidade outros são parcialmente aceitos pelo magistrado responsável por aquele desfecho processual.
A PEDAGOGIA VISUAL E O USO DAS TECNOLOGIAS NO PROCESSO DE ENSINO-APRENDIZAGEM DO ALUNO SURDO
Authors: Alves Pereira Vanessa , Máximo Purificação Marcelo , Lima de Almeida Silva Jucineide 
Published: May 2024

Resumo: A pedagogia visual é um campo que recentemente tem sido explorado de maneira mais ampla no âmbito educacional, ocorre que no que tange a educação dos surdos, experiências visuais são de ampla importância e quando alinhadas as tecnologias, podem potencializar a aprendizagem do aluno surdo. O objetivo central do trabalho é conhecer aspectos da pedagogia visual, refletindo a respeito de seu uso associado as tecnologias. A metodologia do trabalho é de cunho qualitativo, com pesquisas realizadas em sites acadêmicos como Scielo, Google Acadêmico, dentre outros. Nas discussões suscitadas, algumas dificuldades são encontradas no processo de aprendizagem do aluno surdo, como o desconhecimento da Libras por parte do professor e a dificuldade de utilizar metodologias inclusivas. Conclui-se que a pedagogia visual proporciona ao aluno surdo que sua aprendizagem seja intensificada e efetiva, juntamente com o uso das tecnologias, mas este campo necessita de ser explorado de modo mais amplo, além da necessidade de ser incorporado na práxis pedagógica do professor.