bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time to surgery after completion of neoadjuvant chemotherapy does not negatively impact recurrence and survival outcomes in breast cancer patients
Authors: Bek Schin , Sultana Rehena , Du Sherry De Xuan , Tan Qing Ting 
Published: June 2024

AbstractBackgroundThe effect of time to surgery after completion of neoadjuvant chemotherapy and outcomes in breast cancer patients remains poorly defined. Acceptable time to surgery has frequently been arbitrarily defined as between four to eight weeks. This study aims to ascertain if time to surgery after completion of neoadjuvant chemotherapy impacts disease‐free survival (DFS) and overall survival (OS).Materials and methodsThis single‐institution retrospective study included patients who underwent neoadjuvant therapy and subsequent surgery from 2006 to 2017. Demographic, clinicopathological factors, and surgical data from 259 patients were analyzed. 105 patients received surgery within 28 days (group 1). 128 patients received surgery within 29–56 days (group 2), and 26 patients received surgery after 57 days or more (group 3). DFS and OS among the three groups were compared.ResultsAge, race, pre‐chemotherapy stage, tumor type, grade, hormone receptor status, Her2 status, focality, lymphovascular invasion, radiological response to chemotherapy, type of surgery, pathological response to chemotherapy, and receipt of adjuvant radiotherapy were not significantly different between the three groups. Only receipt of adjuvant chemotherapy was statistically significant (p = 0.0230). DFS and OS between the three groups were not found to be significantly different (p = 0.520 and p = 0.369, respectively).ConclusionTime to surgery after completion of neoadjuvant chemotherapy did not appear to affect recurrence or survival outcomes. Findings from this study may allow more flexibility and reduce the burden of scheduling patients for surgery within the usual four‐to‐eight‐week window in centers with resource and scheduling constraints.
Priorities and Distribution in Care
Authors: Werner Gijsbert D. A. , van Riel Arthur , Gijsberts Mérove I. L. , de Visser Marianne 
Published: June 2024

AbstractIn the third part of this report we look at choices with regard to health and social care. In what ways can people and resources be distributed across sectors, organizations, treatments and preventive interventions? How do we divide our public resources between care and other goals? And how do we decide on such questions? Whereas our focus in the previous part was the organization of care and achieving effectiveness or productive efficiency—how to provide care—we now turn our attention to what to do? What care do we offer? And how much of it? Economists refer to this as allocative efficiency: to what ends should resources be allocated and what should attract fewer, or none at all? Allocative efficiency also concerns the extent to which that allocation is in line with society’s wishes and preferences. In other words, are we doing the right things? This is all about priorities, not to mention the practical limits we set to the growth of health and social care. And perhaps even more importantly, about how the choices are made.
Economic consequences of inland waterway disruptions in the Upper Mississippi River region in a changing climate
Authors: Chen Zhenhua , Cheng Junmei 
Published: June 2024

AbstractInland waterway locks have become significant bottlenecks in waterway networks worldwide due to the disruptions caused by aging infrastructure and climate change. While these locks have traditionally received attention for traffic issues, the disruptive impact on the regional economy remains unclear. This study addresses this knowledge gap by assessing the economic impacts of inland water transportation system failures, specifically focusing on disruptions in agricultural commodities within the Upper Mississippi River–Illinois River (UMR–IR) region. These disruptions encompass both unscheduled climate-induced extreme weather events and scheduled maintenance and repair work due to internal system failure. To capture the spatial interdependence between the regional economy and shipping rate changes caused by disruptions, we developed an integrated modeling approach. This approach combines spatial econometric modeling and multi-regional computable general equilibrium modeling techniques. Detailed weekly data from 2013 to 2021, including variations in inland barge rates and environmental conditions, were utilized. The assessment reveals that lock closure events in the UMR-IR region have severe economic consequences, impacting both the region itself and beyond. Conversely, transportation resilience achieved through modal substitution from barge to rail services during disruptive events can substantially reduce GDP losses. Specifically, such resilience measures can reduce GDP losses in the UMR-IR region by 6.6–24.2% and in the rest of the USA by 5.2–19.5%. Overall, these research findings carry significant implications for future planning and investment in inland waterway systems.
Determination of the urinary concentrations of six bisphenols in public servants by online solid-phase extraction-liquid chromatography tandem mass spectrometry
Authors: Estévez-Danta Andrea , Rodil Rosario , Quintana José Benito , Montes Rosa 
Published: June 2024

AbstractBisphenols are widely used as monomers and additives in plastic production. Thus, bisphenol A (BPA) and its most prominent substitutes have been detected in many environmental and human samples. This study proposes an online solid-phase extraction analytical methodology coupled to liquid chromatography with tandem mass spectrometry for the determination of six bisphenols (BPA and bisphenols F (BPF), S (BPS), AF (BPAF), B (BPB), and E (BPE)) in urine samples as an efficient and automated methodology. The method was developed and validated for all bisphenols with good recoveries (92–112%) and repeatability (RSD ≤ 10%) despite the variable matrix effects, except BPAF (which would require a dedicated internal standard), achieving method quantification limits in the 0.05–2.2 ng mL−1 range. The methodology was subsequently applied to 435 urine samples from a non-occupational exposure population (civil servants for the regional government) from Santiago de Compostela (Galicia, Spain). Only BPA, BPF, and BPS were positively detected; the last two presented higher detection frequencies than BPA. When the urinary concentrations are extrapolated to human intake and compared to the European Food Safety Agency (EFSA) tolerable daily intake (TDI) of 2 × 10−4 µg kg−1 day−1 (TDI), all BPA positively identified samples would surpass this threshold. Although no TDI exists currently for the other two identified bisphenols, it is evident that human exposure to bisphenols should be limited. Finally, the results stratification by gender revealed higher levels of exposure to BPF in the women group.
Cohomology Chambers on Complex Surfaces and Elliptically Fibered Calabi–Yau Three-Folds
Authors: Brodie Callum R. , Constantin Andrei 
Published: June 2024

AbstractWe determine several classes of smooth complex projective surfaces on which Zariski decomposition can be combined with vanishing theorems to yield cohomology formulae for all line bundles. The obtained formulae express cohomologies in terms of divisor class intersections, and are adapted to the decomposition of the effective cone into Zariski chambers. In particular, we show this occurs on generalised del Pezzo surfaces, toric surfaces, and K3 surfaces. In the second part we use these surface results to derive formulae for all line bundle cohomology on a simple class of elliptically fibered Calabi–Yau three-folds. Computing such quantities is a crucial step in deriving the massless spectrum in string compactifications.
Entropic Approximation of $$\infty $$-Optimal Transport Problems
Authors: Brizzi Camilla , Carlier Guillaume , De Pascale Luigi 
Published: June 2024

AbstractWe propose an entropic approximation approach for optimal transportation problems with a supremal cost. We establish $$\Gamma $$
Γ
-convergence for suitably chosen parameters for the entropic penalization and that this procedure selects $$\infty $$
∞
-cyclically monotone plans at the limit. We also present some numerical illustrations performed with Sinkhorn’s algorithm.
Inhibiting the CB1 receptor in CIH-induced animal model alleviates colon injury
Authors: Wang Pei-Pei , Cheng Xiao-Qian , Dou Zhan-Jun , Fan Yong-Qiang , Chen Jie , Zhao Li , Han Jian-Xing , Lin Xian-Wang , Wang Bei 
Published: June 2024

Abstract
Obstructive sleep apnea (OSA) can lead to intestinal injury, endotoxemia, and disturbance of intestinal flora. Additionally, as a crucial component of the endocannabinoid system, some studies have demonstrated that cannabinoid 1 (CB1) receptors are closely linked to the multiple organ dysfunction triggered by OSA. However, the role of the CB1 receptor in alleviating OSA-induced colon injury remains unclear. Here, through the construction of the OSA classic model, we found that the colon tissue of chronic intermittent hypoxia (CIH)–induced mice exhibited an overexpression of the CB1 receptor. The results of hematoxylin-eosin staining and transmission electron microscopy revealed that inhibition of the CB1 receptor could decrease the gap between the mucosa and muscularis mucosae, alleviate mitochondrial swelling, reduce microvilli shedding, and promote the recovery of tight junctions of CIH-induced mice. Furthermore, CB1 receptor inhibition reduced the levels of metabolic endotoxemia and inflammatory responses, exhibiting significant protective effects on the colon injury caused by CIH. At the molecular level, through western blotting and real-time polymerase chain reaction techniques, we found that inhibiting the CB1 receptor can significantly increase the expression of ZO-1 and Occludin proteins, which are closely related to the maintenance of intestinal mucosal barrier function. Through 16S rRNA high-throughput sequencing and short-chain fatty acid (SCFA) determination, we found that inhibition of the CB1 receptor increased the diversity of the microbial flora and controlled the makeup of intestinal flora. Moreover, butyric acid concentration and the amount of SCFA-producing bacteria, such as Ruminococcaceae and Lachnospiraceae, were both markedly elevated by CB1 receptor inhibition. The results of the spearman correlation study indicated that Lachnospiraceae showed a positive association with both ZO-1 and Occludin but was negatively correlated with the colon CB1 receptor, IL-1β, and TNF-α. According to this study, we found that inhibiting CB1 receptor can improve CIH-induced colon injury by regulating gut microbiota, reducing mucosal damage and promoting tight junction recovery.

Key points
•CIH leads to overexpression of CB1 receptor in colon tissue.
•CIH causes intestinal flora disorder, intestinal mucosal damage, and disruption of tight junctions.
•Inhibition of CB1 receptor can alleviate the colon injury caused by CIH through regulating the gut microbiota, reducing mucosal injury, and promoting tight junction recovery.

Graphical abstract
Airlift bioreactor–based strategies for prolonged semi-continuous cultivation of edible Agaricomycetes
Authors: Cerrone Federico , Lochlainn Conor Ó , Callaghan Tony , McDonald Peter , O’Connor Kevin E 
Published: June 2024

Abstract
Submerged cultivation of edible filamentous fungi (Agaricomycetes) in bioreactors enables maximum mass transfer of nutrients and has the potential to increase the volumetric productivity of fungal biomass compared to solid state cultivation. These aspects are paramount if one wants to increase the range of bioactives (e.g. glucans) in convenient time frames. In this study, Trametes versicolor (M9911) outperformed four other Agaricomycetes tested strains (during batch cultivations in an airlift bioreactor). This strain was therefore further tested in semi-continuous cultivation. Continuous and semi-continuous cultivations (driven by the dilution rate, D) are the preferred bioprocess strategies for biomass production. We examined the semi-continuous cultivation of T. versicolor at dilution rates between 0.02 and 0.1 h−1. A maximum volumetric productivity of 0.87 g/L/h was obtained with a D of 0.1 h−1 but with a lower total biomass production (cell dry weight, CDW 8.7 g/L) than the one obtained at lower dilution rates (12.3 g/L at D of 0.04 and vs 13.4 g/L, at a D of 0.02 h−1). However, growth at a D of 0.1 h−1 resulted in a very short fermentation (18 h) which terminated due to washout (the specific D exceeded the maximum growth rate of the fungal biomass). At a D of 0.04 h−1, a CDW of 12.3 g/L was achieved without compromising the total residence time (184 h) of the fermentation. While the D of 0.04 h−1 and 0.07 h−1 achieved comparable volumetric productivities (0.5 g/L/h), the total duration of the fermentation at D of 0.07 h−1 was only 85 h. The highest glucan content of cells (27.8 as percentage of CDW) was obtained at a D of 0.07 h−1, while the lowest glucan content was observed in T. versicolor cells grown at a D of 0.02 h−1.

Key points
• The highest reported volumetric productivity for fungal biomass was 0.87 g/L/h.
• Semi-continuous fermentation at D of 0.02 h−1 resulted in 13.4 g/L of fungal biomass.
• Semi-continuous fermentation at D of 0.07 h−1 resulted in fungal biomass with 28% of total glucans.
Retrieval optimization in a warehouse with multiple input/output-points
Authors: Buckow Jan-Niklas , Goerigk Marc , Knust Sigrid 
Published: June 2024

AbstractOptimizing retrieval requests in warehouses is essential for maintaining a smooth flow of products. Most studies on warehouse retrieval optimization have considered no more than two input/output-points for product retrieval. In this paper, we study different variants of a new stacker crane scheduling problem, where pallets have to be retrieved in a warehouse with multiple input/output-points. The goal is to minimize the total travel time of the stacker crane to perform all retrievals. The problem variants we consider require determining either the pallet retrieval sequence, the assignment of pallets to input/output-points, or both. We prove NP-hardness results and identify cases that can be solved in strongly polynomial time. Additionally, we propose transformations to the traveling salesman problem, enabling the application of a vast collection of existing solution techniques. Finally, in an extensive computational study, we compare different problem variants, assess their gain of optimization, and experimentally analyze the impact of various instance parameters.
Low vision aids provision in an urban setting in Germany between 2014 and 2017: a regional population based study with healthcare claims data
Authors: Stolwijk M. L. , Meyer I. , van der Pas S. L. , Twisk J. W.R. , van Nispen R. M.A. , van Rens G. H.M.B. 
Published: June 2024

Abstract
Purpose
Little is known about the utilization of low vision services (LVS) in Germany. To understand which persons and how often these services would be utilized, this study aimed to investigate low vision aids (LVAs) provision in an urban setting and to describe user characteristics and trends in their characteristics.

Methods
A retrospective study based on a population-based healthcare claims database in Cologne (N = ~ 500,000), Germany. The study population comprised individuals, who were continuously insured at four large statutory health insurers and who redeemed a prescription for visual aids or aids for blindness between January 2014 and December 2017. We examined their socio-demographic and clinical characteristics. Trends in characteristics were examined with logistic and linear regression models over time.

Results
Out of ~ 500,000 persons, 781 unique individuals (~ 0.2%) redeemed an LVA prescription. They were mainly female (68.7%), 60 years or older (75.3%) and had macular degeneration (50.6%) and/or glaucoma (25.9%). In the working-age subgroup, 33.8% were employed. Visual aids were most often prescribed (74.1%) and of all types of LVAs, individuals most commonly redeemed a prescription for magnifiers (35.8%), screen readers (34.3%) and/or canes (17.1%). Of the entire study population, 75.4% received their prescription from an ophthalmologist, 5.3% from a general practitioner and 7.1% from other medical specialists. Significant trends in characteristics of individuals who redeemed an LVA prescription were not found.

Conclusions
Between 2014 and 2017, 781 individuals in Cologne redeemed an LVA prescription. They had characteristics which mostly can be explained by the epidemiology of VI. Results indicate that individuals that redeemed LVAs have a magnification requirement of ≥ 1.5-fold and ≥ 6-fold. Furthermore, next to ophthalmologists, general practitioners and other medical specialists seem to play a role in LVA provision as well, which should be taken into account by policy makers when planning interventions for increasing LVS provision. Our findings provide a starting point to examine LVS provision in Germany.
To become part of the team—patient experiences of participating in decision-making for a new treatment (proton beam therapy)
Authors: Sjövall K. , Ahlberg K. , Fessé P. , Fransson P. , Kristensen I. , Ohlsson-Nevo E. , Åkeflo L. , Langegård U. 
Published: June 2024

Abstract
Purpose
The aim of this study was to explore patients’ experience of participation in the treatment decision of proton beam therapy versus conventional radiotherapy.

Background
Proton beam therapy (PBT) has become a treatment option for some cancer patients receiving radiotherapy. The decision to give PBT instead of conventional radiotherapy (CRT) needs to be carefully planned together with the patient to ensure that the degree of participation is based on individuals’ preferences. There is a knowledge gap of successful approaches to support patients’ participation in the decision-making process, which is particularly important when it comes to the situation of having to choose between two treatment options such as PBT and CRT, with similar expected outcomes.

Method
We conducted a secondary analysis of qualitative data collected from interviews with patients who received PBT for their brain tumor. Transcribed verbatims from interviews with 22 patients were analyzed regarding experiences of participation in the decision-making process leading to PBT.

Findings
Participants experienced their participation in the decision-making process to a varying degree, and with individual preferences. Four themes emerged from data: to be a voice that matters, to get control over what will happen, being in the hand of doctors’ choice, and feeling selected for treatment.

Conclusion
A decision for treatment with PBT can be experienced as a privilege but can also cause stress as it might entail practical issues affecting everyday life in a considerable way. For the patient to have confidence in the decision-making process, patients’ preferences, expectations, and experiences must be included by the healthcare team. Including the patient in the healthcare team as an equal partner by confirming the person enables and facilitates for patients’ voice to be heard and reckoned with. Person-centered care building on a partnership between patients and healthcare professionals should provide the right basis for the decision-making process.
Development and validation of the caregiver-report version of the international depression questionnaire (IDQ-CG) and international anxiety questionnaire (IAQ-CG)
Authors: Redican Enya , Sachser Cedric , Berliner Lucy , Pfeiffer Elisa , Martsenkovskyi Dmytro , Hyland Philip , Ben-Ezra Menachem , Shevlin Mark 
Published: June 2024

Abstract
The International Depression Questionnaire (IDQ) and International Anxiety Questionnaire (IAQ) are self-report measures of ICD-11 single episode depressive disorder (DD) and generalised anxiety disorder (GAD). The present study sought to describe the development and psychometric evaluation of the caregiver-report versions of the IDQ and IAQ for children, referred to as the IDQ-CG and IAQ-CG, respectively. Participants were 639 parents living in Ukraine who provided data on themselves and one child in their household as part of “The Mental Health of Parents and Children in Ukraine Study: 2023 Follow-up” study. The latent structure of the IDQ-CG and IAQ-CG were tested using confirmatory factor analysis (CFA), composite reliability (CR) estimates were estimated, and convergent validity was assessed. Prevalence rates of probable ICD-11 DD and GAD were also estimated. CFA results indicated that the IDQ-CG and IAQ-CG were unidimensional, while the internal reliability of both scales was excellent. Convergent validity was established via associations with external measures of internalizing, externalizing, and attention problems as well as trauma exposure. Factors associated with increased IDQ-CG and IAQ-CG scores included pharmacological support for emotional or behavioural problems, delayed milestone development, being forced to move to another part of Ukraine, serious life disruption due to the war, and having experienced a bereavement. Of the total sample, 1.6% met diagnostic requirements for ICD-11 DD and 5.8% met diagnostic requirements for ICD-11 GAD. This study supports the psychometric properties of the IDQ-CG and IAQ-CG. These measures can be effectively used to identify young people in need of mental health support.
Sense of relatedness and study engagement as mediators between students’ peer support and life satisfaction
Authors: Ulmanen Sanna , Tikkanen Lotta , Pyhältö Kirsi 
Published: June 2024

AbstractPrevious research suggests that peer support is an essential component of adolescents’ sense of relatedness in peer relationships and correlates with study engagement and life satisfaction. However, what the underlying mechanisms of these relationships are, has remained unclear. This study examined 1) whether the sense of relatedness or study engagement mediate the effect of peer support on students’ life satisfaction, and 2) whether sense of relatedness mediates the effects of peer support on students’ study engagement. The data were analysed with the structural equation modelling (SEM), using a cross-sectional sample of Finnish upper secondary education students (n = 293) (63% female, 31% male). The results showed that the relationship between peer support and the student life satisfaction beyond the school was fully mediated by students’ experiences of study engagement and sense of relatedness. This suggests that peer support for studying by itself is not sufficient for cultivating student life satisfaction, but its effectiveness depends on whether it positively impacts their study engagement and sense of relatedness. To improve the life satisfaction of upper secondary education students, study-related peer support needs to be cultivated so that it triggers students’ sense of relatedness and study engagement.