bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions
Authors: Kunová Nina , Ondrovičová Gabriela , Bauer Jacob A. , Krajčovičová Veronika , Pinkas Matyáš , Stojkovičová Barbora , Havalová Henrieta , Lukáčová Veronika , Kohútová Lenka , Košťan Július , Martináková Lucia , Baráth Peter , Nováček Jiří , Zoll Sebastian , Kereϊche Sami , Kutejová Eva , Pevala Vladimír 
Published: April 2024

AbstractPhosphorylation plays a crucial role in the regulation of many fundamental cellular processes. Phosphorylation levels are increased in many cancer cells where they may promote changes in mitochondrial homeostasis. Proteomic studies on various types of cancer identified 17 phosphorylation sites within the human ATP-dependent protease Lon, which degrades misfolded, unassembled and oxidatively damaged proteins in mitochondria. Most of these sites were found in Lon’s N-terminal (NTD) and ATPase domains, though little is known about the effects on their function. By combining the biochemical and cryo-electron microscopy studies, we show the effect of Tyr186 and Tyr394 phosphorylations in Lon’s NTD, which greatly reduce all Lon activities without affecting its ability to bind substrates or perturbing its tertiary structure. A substantial reduction in Lon’s activities is also observed in the presence of polyphosphate, whose amount significantly increases in cancer cells. Our study thus provides an insight into the possible fine-tuning of Lon activities in human diseases, which highlights Lon’s importance in maintaining proteostasis in mitochondria.
Low-cost dual-energy CBCT by spectral filtration of a dual focal spot X-ray source
Authors: Li Boyuan , Hu Yuanming , Xu Shuang , Li Bokuan , Inscoe Christina R. , Tyndall Donald A. , Lee Yueh Z. , Lu Jianping , Zhou Otto 
Published: April 2024

AbstractDual-energy cone beam computed tomography (DE-CBCT) has been shown to provide more information and improve performance compared to a conventional single energy spectrum CBCT. Here we report a low-cost DE-CBCT by spectral filtration of a carbon nanotube x-ray source array. The x-ray photons from two focal spots were filtered respectively by a low and a high energy filter. Projection images were collected by alternatively activating the two beams while the source array and detector rotated around the object, and were processed by a one-step materials decomposition and reconstruction method. The performance of the DE-CBCT scanner was evaluated by imaging a water-equivalent plastic phantom with inserts containing known densities of calcium or iodine and an anthropomorphic head phantom with dental implants. A mean energy separation of 15.5 keV was achieved at acceptable dose rates and imaging time. Accurate materials quantification was obtained by materials decomposition. Metal artifacts were reduced in the virtual monoenergetic images synthesized at high energies. The results demonstrated the feasibility of high quality DE-CBCT imaging by spectral filtration without using either an energy sensitive detector or rapid high voltage switching.
Incipient interturn fault detection for ONAN power transformers using electrothermal characteristic fusion analysis
Authors: Zhang Lijing , Sheng Gehao , Zhou Nan , Ni Zizhan , Jiang Xiuchen 
Published: April 2024

AbstractExisting interturn fault detecting methods rely on winding impedance, winding current, and dissolved gases. They are effective only when the insulation is severely damaged. This paper proposes a novel detection method based on fusion analysis of electrothermal characteristics including winding currents, temperatures of four areas on the tank wall, top oil and ambient temperatures, which can identify the interturn fault at an early stage. When an incipient interturn fault occurs, the heat generated by the faulty turns is transferred to the oil and tank wall, leading to an increase in top oil and tank wall temperatures. Thus, the incipient fault can be detected by analysing these electrothermal characteristic parameters. Borrowing the idea of digital twin (DT), this method establishes a high‐fidelity simulation model to simulate the transformer electrothermal characteristics under different operating conditions. Afterward, an intelligent neural network is adopted to extract the quantitative relationship between the eight feature attributions and fault conditions. Finally, this neural network is utilized to detect the incipient interturn fault for the transformer entity. Case studies are conducted on a 100 kVA transformer with oil natural air natural (ONAN) cooling mode. The detection accuracy is improved by 68.5% compared to the winding current‐based method.
Meaning as referential work
Authors: Koole Tom 
Published: April 2024

Abstract
This epilogue to the Special Issue on Interactional Semantics discusses the contributions to the Special Issue in
relation to other research to support three arguments. (i) The choice of Interactional Semantics to take the referential function
of language (Jakobson) as its object of research is a welcome choice. (ii) The use of the term ‘meaning’ for this research object
is potentially confusing and could be replaced by ‘referential work’. (iii) A research topic which could be included in
Interactional Semantics and has not been articulated as such, is the way in which the choice of a referential expression
establishes the referent as a particular social reality and is a tacit proposal to the interlocutors to talk about this referent
in these terms.
When dissatisfactory experiences turn into conflict
Authors: Hernández López María de la O 
Published: April 2024

Abstract
Online reviews have partly become a complaints channel in which posters vent their negative feelings (Henning-Thurau et al. 2004), but the contents, as well as the way posters express their
opinions, may vary depending on the type of review, the platform, and the consumers’ expectations, among others. This study
explores 600 negative reviews in Spanish, posted to the outsourced review site Trustpilot about three different companies: Zara,
Airbnb, and Travelgenio. The aim of this study is to examine: (1) the themes that posters raise as the source of complaint or
conflict; and (2) the impoliteness formulae (Culpeper 2016) found in the three
datasets. The results show that reviews are structured around a limited set of themes and formulae, which range from rather
descriptive evaluations that report moderate dissatisfaction (Zara reviews) to highly aggressive reviews related to communication
problems and significant loss of money and time (Travelgenio).
Actional nominalization in Present-Day English in the light of
the Referenced Index of Competition
Authors: Fernández-Domínguez Jesús 
Published: April 2024

Abstract
The suffix ‑ment is a
nominalizer which has been portrayed as practically “defunct” (Anshen & Aronoff
1999: 24), although recent coinages cast doubts on conclusive
statements (Bauer et al.
2013). This investigation is based on nonce formations
from the BNC and COCA and aims at exploring nominalizations which
compete for the meaning action in order to understand the
current degree of productivity of the processes involved. This is
done through a corpus-based quantitative approach which considers
‑ment in the light of its relationship to other
competitors, e.g. ‑ing or conversion. The results
reveal that ‑ment is normally surpassed by other
processes, but also that it has found a niche of application which
secures a minimal productive status.
Competition of lexicon vs. pragmatics in word formation
Authors: Fukushima Kazuhiko 
Published: April 2024

Abstract
Pragmatic information (motivating an
onomasiological perspective) interacts and competes with formal
grammar (embodying a semasiological inclination), namely, the
lexicon and its formal word-formation mechanisms to give rise to
intricate patterns of argument structures of Japanese lexical V-V
compounds. The compound formation process involves argument
synthesis (argument matching) displaying intricacies
inexplicable without appealing to speaker intentions regarding
reference choices, argument designation preferences, perspective
adjustment, etc. Downplaying or denying interaction and competition
between the two domains above would undermine generalization,
analytical precision, efficiency, and creativity within
morphology.
Computational Description of Physical Systems
Authors: Anderson Neal G , Piccinini Gualtiero 
Published: April 2024

Abstract
This chapter introduces computational descriptions of physical systems (CDPSs), which are physical descriptions of physical systems (PDPSs) that map onto abstract computational definitions of computing systems (CDCSs) via physical-to-computational mappings (PCMs). Physical-to-computational mappings are dynamically self-consistent mappings from some or all elements of a PDPS to all elements of a CDCS, where dynamical self-consistency requires that the transformations of all computationally relevant physical states conform to the transformations of the computational states onto which they map. This minimal notion of a CDPS will be placed in the context of stronger alternatives in Chapter 4, where minimal qualifying criteria that any CDPS must satisfy are supplemented by additional criteria that give rise to stronger classes of CDPSs. The classification of CDPSs by the restrictiveness of the strength criteria they satisfy provides a useful and transparent strategy for evaluating claims that particular physical systems implement particular computations.
Unlimited Pancomputationalism
Authors: Anderson Neal G , Piccinini Gualtiero 
Published: April 2024

Abstract
This chapter considers unlimited pancomputationalism, which in its simplest form holds that every physical system implements every computation. It briefly reviews the origins of unlimited pancomputationalism and considers in detail the most precise and influential arguments that support it. It analyzes these arguments through the lens of our evaluation framework, reveals the underlying computational descriptions of physical systems employed in these arguments to be weak, and discusses what one must accept about the nature of physical computation to accept these arguments. It concludes that, in failing to satisfy criterion PCE (physical-computational equivalence) and thus failing to ensure that formal features of computations are fully and faithfully reflected in physical dynamics of systems taken to implement them, the physical systems employed in arguments for unlimited pancomputationalism lack meaningful signatures of computation. This undercuts the strongest arguments for unlimited pancomputationalism and identifies the missing ingredient responsible for their failure: physical-computational equivalence.
Discovery of New Genomic Configuration of Mating-Type Loci in the Largest Lineage of Lichen-Forming Fungi
Authors: White Kristin H , Keepers Kyle , Kane Nolan , Lendemer James C 
Published: April 2024

Abstract
The genetic architecture of mating-type loci in lichen-forming fungi has been characterized in very few taxa. Despite the limited data, and in contrast to all other major fungal lineages, arrangements that have both mating-type alleles in a single haploid genome have been hypothesized to be absent from the largest lineage of lichen-forming fungi, the Lecanoromycetes. We report the discovery of both mating-type alleles from the haploid genomes of three species within this group. Our results demonstrate that Lecanoromycetes are not an outlier among Ascomycetes.
Opportunities and Barriers to Pediatric Antimicrobial Stewardship by Community Pharmacists
Authors: Alzard Shahd , Wen Jane , Huynh Nguyen Phuong Quynh , Shirkhanzadeh Shahrzad , Tso Jocelyn Y , Rabino Meynard , Vanevski Marijana , Bryant Penelope A , Buttery Jim , Haeusler Gabrielle M , Lim Angelina S 
Published: April 2024

Abstract
Community Pharmacists (CPs) are easily accessible and can advocate for the appropriate use of antibiotics in children. Semi-structured interviews were conducted with 47 CPs and 46 parents/caregivers. Both groups expressed challenges to intervening when antibiotics have already been prescribed and highlighted the need for more support for CPs to make informed decisions.
Underreporting Supplements: A Case of Drug-induced Liver Injury Due to a Testosterone Booster
Authors: Manhas Ashna , Arnold Casey Genevieve , Bush Allison Marie 
Published: April 2024

ABSTRACT
Acute liver injuries (ALIs) are caused by a wide range of etiologies, and determining the cause can often be challenging. Detailed history taking is essential in patients with liver injuries to promptly determine the underlying source of injury and for timely treatment and prognosis. A 27-year-old active duty man presented to the emergency department (ED) with jaundice. On medication reconciliation, he only reported taking acetaminophen for a recent upper respiratory infection. The patient had an ALI and was treated with N-acetyl cysteine for presumed acetaminophen toxicity. Initially, his liver-associated enzymes (LAEs) improved, but 2 weeks after discharge, he returned to the ED upon referral from ship medical for jaundice and worsening liver injury. Repeated query into the patient’s history revealed that he was using a testosterone booster supplement for 6 months preceding initial hospitalization. After evaluation of other etiologies for liver injury returned negative, drug-induced liver injury from the testosterone booster was determined to be the underlying etiology. With discontinuation of the supplement, his liver injury improved. Hepatotoxicity is a major concern in supplement use; however, it is largely underreported. Supplements are often not recognized or reported as medications by patients, leading to failure to identify them as potential toxicants. This case highlights the importance of including supplement education and questioning in the evaluation of ALI and maintaining a high index of suspicion when other common etiologies of liver disease are negative.
Bad Air and Boiled Horsehair
Authors: Fazal Tanisha M. 
Published: April 2024

Abstract
This chapter analyzes Civil War military medicine in two parts. The first part focuses on the role of disease, which was the primary killer in the Civil War. The second part focuses on the role of “medical logistics,” such as hospitals, staffing, evacuation, and data collection. Unlike the treatment of disease, which remained fairly rudimentary over the course of the war, the Civil War saw significant advancements in medical logistics. The chapter also contains an analysis of Civil War veterans’ benefits, with a focus on the historically expansive pension system set up after the war. Combined, the discussion of military medicine and veterans’ benefits provides a window into the long-term costs of the Civil War.
Introduction
Authors: Varon Elizabeth R 
Published: April 2024

Abstract
In July 1864, in the fourth summer of the Civil War, the popular Northern journal Harper’s Weekly featured an article entitled “Fighting for Our Foes.” The article invoked the “terrorism under which the people of the rebellious States have long suffered”—the extortion, intimidation, and violence perpetrated by elite slaveholders against the Southern masses in order to keep “their white fellow-citizens ignorant and debased.”
March of Redemption
Authors: Varon Elizabeth R 
Published: April 2024

Abstract
“Startling News from Washington—A Promising Victory Turned into a Disastrous Defeat.” So the New York Herald reported from Manassas, Virginia, where the Federals clashed with the Confederates on July 21, 1861, along a tributary stream of the Potomac River called Bull Run. As Lincoln and his allies regrouped in the wake of this alarming start to the war, three major challenges loomed: thwarting secessionists in the slaveholding border states, resolving the status of slaves who ran from their masters to Union lines, and finding commanders who would not just win battles but also set the right tone for the war effort. Addressing these challenges was politically delicate work. Northerners struggled to discern what sorts of policies—what combination of force and incentive—would break the spell of secession and bring the Southern rebels to their senses.
Sacred Soil
Authors: Varon Elizabeth R 
Published: April 2024

Abstract
As McClellan’s army bore down on the rebel capital in May 1862, the Richmond Daily Dispatch conjured images of the “pollution” of her soil by the “hireling hoards of the North.” The city must be defended at all costs, it warned, for “to lose Richmond is to lose Virginia.” “To die in her streets would be bliss,” the paper intoned, and “would consecrate the spot anew, and wash it of every stain.” In Confederate eyes, McClellan’s grand campaign in Virginia epitomized the dark dreams of invasion and conquest that secessionists had long imputed to the abolitionist North. But Federal soldiers who moved up the Peninsula imagined themselves to be an army of liberation: they claimed Southern soil and Southern history as American, and imagined that Union victory would both regenerate the land and perpetuate the true legacy of the Revolution and of the Virginia Founders. On the Northern home front, defenders of an expanded confiscation policy aimed to punish treason and reward loyalty in the name of military necessity, while Lincoln, whose offer of compensated emancipation was rebuffed again by the border states, laid the groundwork for emancipation by presidential fiat in the insurgent states. In the face of renewed calls for colonization, African Americans staked their own claim, based on centuries of sacrifice and labor, to American soil and citizenship.
Countdown to Jubilee
Authors: Varon Elizabeth R 
Published: April 2024

Abstract
Antietam was the victory Lincoln had waited for, and on September 22, 1862, in keeping with the secret pledge he had made to his cabinet, he promulgated his preliminary Emancipation Proclamation. The document reiterated the standing offer to loyal slaveholders: if they undertook their own voluntary measures to gradually dismantle slavery, Lincoln would urge Congress to provide them with pecuniary compensation for their lost property and federal aid for colonization of the freedpeople. It reprised the major provisions of the Second Confiscation Act, underscoring that U.S. military forces would no more act as slave catchers: all slaves of rebels who came to Union lines or under Union occupation would be “deemed captives of war... forever free of their servitude and not again held as slaves.” But Lincoln’s edict also went beyond the earlier colonization proposals and Confiscation Acts. Levied under his presidential war powers, the preliminary proclamation was a warning: as of January 1, 1863, Lincoln told disloyal Southerners, “all persons held as slaves within any state, or designated part of a state, the people whereof shall then be in rebellion against the United States shall be then, thenceforward, and forever free.” Implicitly acknowledging both the self-emancipation of fugitive slaves and the army’s role as the beacon for flight, the proclamation promised that the federal government and military would “recognize and maintain the freedom of such persons” and “not repress... any efforts they may make for their actual freedom.”
The Emancipation Proclamation
Authors: Varon Elizabeth R 
Published: April 2024

Abstract
Lincoln inscribed the Emancipation Proclamation into law at 2:00 p.m. on January 1, 1863, after the conclusion of a three-hour New Year’s Day reception at the Executive Mansion. The president’s hand trembled as he wrote his name, a sign of physical wear from glad-handing with the public. But his sense of purpose was unshakeable. “I never in my life felt more certain that I was doing right than I do in signing this paper,” he said to Seward.
Rallying Point
Authors: Varon Elizabeth R 
Published: April 2024

Abstract
“What Horror surrounds me! Here I am, helpless and bleeding, my flesh lacerated, my thigh-bone broken; the dead so ghastly, the dying and the wounded all about me; my regiment falling back, the enemy advancing. What will become of me?” The terror Union private Arthur van Lisle felt on September 19, 1863, the first day of the battle of Chickamauga, is palpable, even in words he wrote thirty years after the event. Van Lisle’s 1893 reminiscence continued, “My eyes are riveted to that glorious old banner.... Will it recover its lost ground and save the boys who fell where it first advanced? Will it ever reach me?”
Is This Hell?
Authors: Varon Elizabeth R 
Published: April 2024

Abstract
In February 1864 Brigadier General Judson Kilpatrick, a brash Union cavalry commander known for his bravery and recklessness, proposed to Stanton and then to Lincoln a plan for a raid directly on Richmond. Kilpatrick imagined that the raid would disrupt Confederate communications and supply lines, strike fear in the hearts of the city’s inhabitants, and free inmates languishing in Confederate prisons; Stanton directed that Kilpatrick’s raiders should also distribute hundreds of copies of the December 8 amnesty proclamation among civilians. The plan called for a carefully orchestrated joint action by Kilpatrick and his compatriot Colonel Ulric Dahlgren: Kilpatrick would attack Richmond with a force of 3,000 troops from the northwest, while Dahlgren and a smaller force assailed it from the south. The raid started promisingly enough. Setting out on February 28 and meeting little Confederate resistance, Kilpatrick’s troopers reached Richmond’s outer fortifications by March 1, 1864. But then the mission went off the rails. Under artillery fire from the Confederates, Kilpatrick lost his nerve and retreated, leaving Dahlgren’s men isolated and forcing them to retreat as well. Groping their way through hostile terrain, under rebel pursuit in the darkness of night, Dahlgren and some ninety of his men got separated from the rest of his command and then ambushed on March 2 by rebel cavalry. The young colonel was killed and all but twenty-one of his soldiers captured.
Campaign Season
Authors: Varon Elizabeth R 
Published: April 2024

Abstract
“Atlanta is ours, and fairly won,” read William Sherman’s September 3, 1864, dispatch to Washington, D.C., announcing his capture of the rebel stronghold. “Since the 5th of May, we have been in one constant battle or skirmish.” Over four months, the Union had sustained 37,000 casualties and inflicted 32,000 on the Confederate army. This news, coming across the telegraph wires just two days after the Chicago convention declared the war effort a failure, could not have come at a more propitious time for Lincoln. In Auburn, New York, at a public celebration of Sherman’s victory, William Seward offered a de facto campaign speech for Lincoln, calling the National Union party the true peace party. Propositions of peace with a restoration of the Union, he explained, would come “not from the Confederates in authority, nor through them, but from citizens and states under and behind them... just so fast as those citizens and states shall have been delivered by the Federal arms from the usurpation by which they are oppressed.” The Union would greet liberated Southerners as “brethren who have come back from their wanderings, to seek a shelter in the common ark of our national security and happiness.” And redeemed white Southerners would do the right thing by dismantling slavery, the “mainspring of the rebellion.” “The Union men in all the slave states that we have delivered are even more anxious than we are to abolish slavery.