bluuebunny/crossref_metadata_2025_split huggingface dataset:
Statistical downscaling of precipitation in northwestern Iran using a hybrid model of discrete wavelet transform, artificial neural networks, and quantile mapping
Authors: Taie Semiromi Majid , Koch Manfred 
Published: May 2024

AbstractDownscaling of daily precipitation from Global Circulation Models (GCMs)-predictors at a station level, especially in arid and semi-arid regions, has remained a formidable challenge yet. The current study aims at proposing a coupled model of Discrete Wavelet Transform (DWT), Artificial Neural Networks (ANNs), and Quantile Mapping (QM) for statistical downscaling of daily precipitation. Given the historic (1978–2005) and future (2006–2100) predictors of eight-selected GCMs under Representative Concentration Pathways (RCPs) 2.6, 4.5, and 8.5, a viable DWT-ANN model was developed for each station. Subsequently, we linked QM to DWT-ANN for bias correction and drizzle effect postprocessing of the DWT-ANN-historic/future projected precipitation. The skill of DWT-ANN-QM was demonstrated using various evaluation metrics, including Taylor diagram, Quantile–Quantile plot, Empirical Cumulative Distribution Function, and wet/dry spell analysis. We appraise the efficacy of the coupled model at 12 weather stations over the Gharehsoo River Basin (GRB) in northwestern Iran. Compared to the observed wet/dry spells, the dry-spells were better simulated via DWT-ANN-QM rather than the wet-spells wherein length and exceedance probability of the spells were overestimated. Results indicated that the future precipitation across the GRB will rise, on average, from 10 to 17% depending on weather station. Seasonal spatial distribution of the middle future (2041–2070) precipitation illustrated that an increase for fall and winter, especially, is expected, whereas the amount of the future spring and summer precipitation is projected to be declined. Having been developed and tested in a semi-arid basin, the efficacy of the coupled model should be further assessed in more humid climates.
Sexually transmitted infection and teenage pregnancy in adolescents having parents with schizophrenia: a retrospective cohort study of 64,350 participants
Authors: Hsu Ju-Wei , Chen Li-Chi , Huang Kai-Lin , Tsai Shih-Jen , Bai Ya-Mei , Su Tung-Ping , Chen Tzeng-Ji , Chen Mu-Hong 
Published: May 2024

Abstract
Background
The risks of sexually transmitted infections (STIs) and teenage pregnancy in the offspring of parents with schizophrenia remain unknown.

Methods
From the Taiwan National Health Insurance Research Database, 5,850 individuals born between 1980 and 1999 having any parent with schizophrenia and 58,500 age-, sex-, income- and residence-matched controls without parents with severe mental disorders were enrolled in 1996 or on their birthdate and followed up to the end of 2011. Those who contracted any STI or became pregnant in adolescence during the follow-up period were identified.

Results
Cox regression analyses demonstrated that offspring of parents with schizophrenia (hazard ratio [HR]: 1.21, 95% confidence interval [CI]: 1.02–1.44), especially daughters (HR: 1.30, 95% CI: 1.06–1.58), were more likely to contract any STI later in life than the control comparisons. In addition, daughters of parents with schizophrenia had an elevated risk of being pregnant in their adolescence (HR: 1.47, 95% CI: 1.29–1.67) compared with those having no parents with severe mental disorders.

Discussion
The positive relationship between parental schizophrenia and offspring STIs and teenage pregnancy necessitates clinicians and public health officers to closely monitor the sexual health in the offspring of parents with schizophrenia so that optimal and prompt preventive measures can be taken in the at-risk group.
Green subsidies as strategic trade policy tools
Authors: Buccella Domenico , Fanti Luciano , Gori Luca , Sodini Mauro 
Published: May 2024

AbstractIn a third-country market model in which two export countries adopt environmental policies (taxes and subsidies), this article analyses how an abatement (“green”) subsidy can become a potential strategic trade policy tool. When governments set the optimal policy considering their local environmental damages, a rich set of equilibria arises. In contrast to the standard result, it is shown that subsidising pollution abatement can 1) emerge as the unique Pareto-efficient Nash equilibrium of the policy game, 2) be the only feasible environmental policy when environmental awareness is low, irrespective of the efficiency of the cleaning technology, and 3) emerge as the unique Pareto-inefficient Nash equilibrium of the policy game at the end of the ecological transition. The article also tackles some dynamic issues that the policy game implies.
Social cognition training using virtual reality for people with schizophrenia: a scoping review
Authors: Pérez-Ferrara D. A. , Flores-Medina G. Y. , Landa-Ramírez E. , González-Sánchez D. J. , Luna-Padilla J. A. , Sosa-Millán A. L. , Mondragón-Maya A. 
Published: May 2024

AbstractTo date, many interventions for social cognition have been developed. Nevertheless, the use of social cognition training with virtual reality (SCT-VR) in schizophrenia is a recent field of study. Therefore, a scoping review is a suitable method to examine the extent of existing literature, the characteristics of the studies, and the SCT-VR. Additionally, it allows us to summarize findings from a heterogeneous body of knowledge and identify gaps in the literature favoring the planning and conduct of future research. The aim of this review was to explore and describe the characteristics of SCT-VR in schizophrenia. The searched databases were MEDLINE, PsycInfo, Web of Science, and CINAHL. This scoping review considered experimental, quasi-experimental, analytical observational and descriptive observational study designs. The full text of selected citations was assessed by two independent reviewers. Data were extracted from papers included in the scoping review by two independent reviewers. We identified 1,407 records. A total of twelve studies were included for analyses. Study designs were variable, most research was proof-of-concept or pilot studies. Most SCT-VR were immersive and targeted interventions. Number of sessions ranged from 9 to 16, and the duration of each session ranged from 45 to 120 min. Some studies reported a significant improvement in emotion recognition and/or theory of mind. However, SCT-VR is a recent research field in which the heterogeneity in methodological approaches is evident and has prevented the reaching of robust conclusions. Preliminary evidence has shown that SCT-VR could represent a feasible and promising approach for improving SC deficits in schizophrenia.
Blood pressure monitoring in elderly migraineurs starting an anti-CGRP monoclonal antibody: a real-world prospective study
Authors: Mascarella Davide , Andrini Giorgia , Baraldi Carlo , Altamura Claudia , Favoni Valentina , Lo Castro Flavia , Pierangeli Giulia , Vernieri Fabrizio , Guerzoni Simona , Cevoli Sabina 
Published: May 2024

Abstract
Background
While monoclonal antibodies (mAbs) targeting the CGRP pathway have revolutionized migraine management due to their improved tolerance and adherence, concerns remain about their potential impact on blood pressure (BP), especially in older patients, due to CGRP-mediated vasodilation blockade. Given the growing use of these therapies in older populations, assessing their cardiovascular (CV) safety is of paramount importance.

Methods
This multicentric observational prospective study focused on migraine sufferers aged ≥ 60 who began erenumab, galcanezumab, or fremanezumab for prevention. Baseline, three-month, and twelve-month BP measurements were collected. Changes in antihypertensive medication and "Newly or Worsened Hypertensive" patients (NWHP) were assessed.

Results
Among 155 patients receiving anti-CGRP mAbs (40 Erenumab, 47 Galcanezumab, 68 Fremanezumab), 42.5% had hypertension history and 39% were on antihypertensive treatment. No significant systolic or diastolic BP changes occurred at any time point compared to baseline (all p > 0.05), with no differences between the three groups. After one year, 20/155 (12.9%) patients were considered NWHP; 11/20 had prior hypertension, and 5/11 adjusted antihypertensive therapy. Among 9/20 newly hypertensive patients, 5/9 had a single measurement above the normal threshold with no requirement for new pharmacological therapy. A higher baseline BP value was associated with increased BP (p = 0.002).

Conclusions
The study concludes that treatment with anti-CGRP mAbs over one year does not significantly affect BP in patients aged ≥ 60, nor does it increase the incidence of hypertension compared to general population trends. Nonetheless, continuous monitoring and further long-term studies are necessary to fullya scertain the cardiovascular safety of these medications in the elderly.
Phosphodiesterase-5 inhibitors use and the risk of alzheimer's disease: a systematic review and meta-analysis
Authors: Abouelmagd Moaz Elsayed , Abdelmeseh Maickel , Elrosasy Amr , Saad Yousef Hesham , Alnajjar Asmaa Zakria , Eid Mahmoud , Hassan Atef , Abbas Abdallah 
Published: May 2024

Abstract
Background
The management of Alzheimer's disease (AD) poses considerable challenges, necessitating the pursuit of innovative therapeutic approaches. Recent research has spotlighted the promising role of phosphodiesterase type 5 inhibitors (PDE5Is) in reducing the prevalence of AD, utilizing their vasodilatory properties to suggest a potential neuroprotective effect. This meta-analysis and systematic review aims to assess the relationship between the use of PDE5Is and the risk of AD.

Methods
A detailed examination was carried out across several electronic databases till March 2024, including PubMed, Web of Science, Scopus, CENTRAL, and Embase. The focus was on identifying studies that compare the occurrence of AD among PDE5I users vs non-users. Through a random-effects model, pooled hazard ratios (HRs) were calculated, in alignment with guidelines from the Cochrane Handbook for Systematic Reviews and Meta-Analysis and the PRISMA standards.

Results
This analysis included six studies, cumulating a participant count of 8,337,313, involving individuals treated with sildenafil, tadalafil, and vardenafil, against a control group undergoing other or no treatments. The cumulative HR for AD risk among PDE5I users versus the control group was 0.53 (95% CI: 0.32–0.86, p = 0.008), signaling a markedly reduced likelihood of AD development in the PDE5I group. Particularly, sildenafil usage showed a significant risk reduction (HR: 0.46, 95% CI: 0.31–0.70, p < 0.001), while findings for tadalafil and vardenafil were not significant. Test of subgroup differences found no difference between male and female participants in the risk of AD.

Conclusions
Our findings suggest that the use of PDE5Is is associated with a reduced risk of AD, highlighting its potential as a protective agent against neurodegenerative diseases. Given the very low quality of evidence and the heterogeneity among the included studies, further high-quality research is warranted to confirm these findings and elucidate the underlying mechanisms. Register number PROSPERO 2024: CRD42024522197.
Measuring digital development: ranking using data envelopment analysis (DEA) and network readiness index (NRI)
Authors: Bánhidi Zoltán , Dobos Imre 
Published: May 2024

AbstractThe Network Readiness Index (NRI) is one of the most prominent indicators that shows the digital development of countries. In contrast to the International Digital Economy and Social Index (I-DESI) of the European Union (EU), in 2020, it showed the development of 134 countries compared to 45 countries in I-DESI of EU, which measures only the most developed countries. The aim of this paper is to provide a viable alternative framework to the equal weights scheme of the original NRI scoring model using the Data Envelopment Analysis (DEA) Without Explicit Input (WEI) method and Common Weight Analysis (CWA) method. After determining the common weights, we compare the digital development of the countries in the NRI dataset based on the results obtained, focusing on the countries of the Central and Eastern European (CEE) region and the former Soviet Union.
Perceptions on and impacts of environmental changes under multiple stressors: a case study from two communities in northern Fennoscandia
Authors: Eilola Salla , Horstkotte Tim , Forbes Bruce C. , Habeck Joachim Otto , Komu Teresa , Rasmus Sirpa , Fagerholm Nora 
Published: May 2024

AbstractAgainst the backcloth of particularly fast environmental change in the Arctic, this study juxtaposes local perceptions of environmental change in two communities in the boreal zone of Northern Europe with scientific data. The local knowledge was gathered through an online participatory mapping survey among the two communities and scientific evidence was gathered from various peer-reviewed and official monitoring sources. Local knowledge of environmental change in Savukoski (Finland) resembles that in Jokkmokk (Sweden). Most perceived changes are in line with scientific studies, public discourse, and local concerns in the Arctic. What differs, however, is the degree of correspondence between local and scientific knowledge on certain phenomena: some dynamics are well documented in both local and scientific observations whereas other dynamics require more nuanced scientific research, particularly considering their relevance for local livelihoods. Among these are: berry yields, the abundance of mosquitoes and other Nematocera, peatland thaw and frost, and changes in river and lake ice conditions. It is noteworthy that in both Savukoski and Jokkmokk, for many people the most impactful changes are caused by resource extraction rather than climate change. Local concerns and perceptions of environmental change are not all shared nor easily translate into adaptation strategies, but nonetheless they have clear policy implications.
Precipitation and hydrological extremes during the warm season in response to climate change: the example from the Polish Carpathians
Authors: Wypych Agnieszka , Ustrnul Zbigniew 
Published: May 2024

AbstractThis study assesses the long-term variability of extreme precipitation events in the Carpathian region of Poland in relation to climate change and its potential impact on river regime. Focusing on eight catchments with undisturbed runoff regimes, the research utilized daily data from May to October between 1951 and 2022. This data included precipitation totals from 23 gauging stations, discharge values from eight water level gauging stations, and gridded precipitation data from the E-OBS dataset. Additionally, future projections for 2026–2060 under two RCP scenarios (4.5 and 8.5) were generated using five GCM-RCM model combinations from the EURO-CORDEX simulations. The study explored the relationship between precipitation and discharge, using probability techniques to identify extreme events. This study highlights the strong linkages between extreme precipitation and discharge in the region, indicating an elevated flood risk due to increased precipitation variability and volume. Despite no significant trends in the frequency of precipitation extremes being observed in the historical analysis, an increase in seasonal precipitation totals is projected, although with considerable uncertainty.
Establishment of a neutrophil extracellular trap-related prognostic signature for colorectal cancer liver metastasis and expression validation of CYP4F3
Authors: Tang Xiao-Li , Xu Zi-Yang , Guan Jiao , Yao Jing , Tang Xiao-Long , Zhou Zun-Qiang , Zhang Zheng-Yun 
Published: May 2024

AbstractLiver metastasis stands as the primary contributor to mortality among patients diagnosed with colorectal cancer (CRC). Neutrophil extracellular traps (NETs) emerge as pivotal players in the progression and metastasis of cancer, showcasing promise as prognostic biomarkers. Our objective is to formulate a predictive model grounded in genes associated with neutrophil extracellular traps and identify novel therapeutic targets for combating CRLM. We sourced gene expression profiles from the Gene Expression Omnibus (GEO) database. Neutrophil extracellular trap-related gene set was obtained from relevant literature and cross-referenced with the GEO datasets. Differentially expressed genes (DEGs) were identified through screening via the least absolute shrinkage and selection operator regression and random forest modeling, leading to the establishment of a nomogram and subtype analysis. Subsequently, a thorough analysis of the characteristic gene CYP4F3 was undertaken, and our findings were corroborated through immunohistochemical staining. We identified seven DEGs (ATG7, CTSG, CYP4F3, F3, IL1B, PDE4B, and TNF) and established nomograms for the occurrence and prognosis of CRLM. CYP4F3 is highly expressed in CRC and colorectal liver metastasis (CRLM), exhibiting a negative correlation with CRLM prognosis. It may serve as a potential therapeutic target for CRLM. A novel prognostic signature related to NETs has been developed, with CYP4F3 identified as a risk factor and potential target for CRLM.
Stand structural effects on growth distribution and growth efficiency in Scots pine and Mediterranean pine in Spain
Authors: Ordóñez Cristobal , Maguire Douglas A. , Pando Valentín , Bravo Felipe 
Published: May 2024

AbstractUnderstanding the growth efficiency of individual trees, or growth per unit of resource utilization, can inform silvicultural management strategies to maximize tree and stand growth. Stand structure—the size and spatial distributions of trees within the stand—strongly influences water, light, and nutrient availability, as well as the resource-use efficiency of each tree. Key silvicultural tools for stand management include manipulating tree density, size distribution, and arrangement by controlling natural regeneration, artificial seeding, planting seedlings, and/or subsequent thinning of established trees. We analyzed two sets of plots from even-aged stands of common coniferous species in central Spain, 106 pure Scots pine (Pinus sylvestris) and 92 pure Mediterranean pine (Pinus pinaster), to examine the dynamics of the dominance hypothesis, the relationship between stand structure and growth, and the relationship between structure and growth efficiency. Our main findings revealed a negative impact of size-class uniformity on stand growth in both Scots pine and Mediterranean pine, while the positive effect of tree size on growth efficiency was supported for Mediterranean pine stands but uncertain for Scots pine. At the operational level, our results highlight how thinning intensity is more important than the thinning method in Mediterranean pinewoods and how thinning can benefit the provision of multiple ecosystem services. We also recommend integrating dominance effects on growth into individual tree modelling.
Trans-eyelid distribution of epinastine to the conjunctiva following eyelid application in rabbits
Authors: Mochizuki Takaharu , Hata Tatsuya , Mori Naoto , Yamazaki Takashi , Noto Takahisa , Mano Hidetoshi 
Published: May 2024

Abstract
Purpose
To reveal the penetration of epinastine, an anti-allergic ophthalmic agent, into the eyelid and its distribution to the conjunctiva after administration of a cream formulation on rabbit eyelid skin.

Study design
Experimental study.

Methods
Rabbits were treated with 0.5% epinastine cream on hair-shaved eyelids, followed by preparation of eyelid tissue slices to determine spatial tissue distribution of epinastine by liquid chromatography-tandem mass spectrometry (LC-MS/MS) quantification using laser-microdissected tissues and desorption electrospray ionization mass spectrometry imaging (DESI-MSI). In addition, following either eyelid application of 0.5% epinastine cream or ocular instillation of 0.1% epinastine eye drops, concentration-time profiles of epinastine in the palpebral conjunctiva and bulbar conjunctiva were determined using LC-MS/MS.

Results
Laser microdissection coupled with LC-MS/MS analysis detected high concentrations of epinastine around the outermost layer of the eyelid at 0.5 h post-administration that gradually diffused deeper into the eyelid and was distributed in the conjunctival layer at 8 and 24 h post-administration. Similar time-dependent drug distribution was observed in high-spatial-resolution images obtained using DESI-MSI. Epinastine concentrations in the conjunctival tissues peaked at 4–8 h after administration of 0.5% epinastine cream and then decreased slowly over 72 h post-administration. In contrast, epinastine concentrations peaked quickly and decreased sharply after epinastine eye drop administration.

Conclusion
After the application of epinastine cream to the eyelid skin, epinastine gradually permeated the eyelid. The compound was retained in the conjunctiva for 8–24 h post-administration, indicating that epinastine cream is a promising long-acting formulation for treating allergic conjunctivitis.
Beyond biophobia: positive appraisal of bats among German residents during the COVID-19 pandemic - with consequences for conservation intentions
Authors: Straka Tanja M. , Coleman Joanna L. , Macdonald Ewan A. , Rogge Svea , Kingston Tigga , Jacobs Maarten H. 
Published: May 2024

AbstractBats are often considered to be objects of biophobia, i.e., the tendency to respond with a negative emotion, such as fear or disgust, especially during the COVID-19 pandemic. However, existing studies have rarely compared both positive and negative emotions towards bats, leading to a potential negativity bias. This is crucial given the importance of emotions to bat-related human behaviours, such as in bat conservation-related actions. Via two online surveys conducted among German residents, we aimed to (i) assess positive and negative emotions towards bats, (ii) examine emotional shifts during the pandemic and (iii) explore how emotions, along with socio-demographics, predict the intent to perform bat-conservation actions. The first survey was undertaken ten months after the official declaration of the COVID-19 pandemic (December 2020 - January 2021), when bats gained societal attention due to speculation about the origin of the SARS-CoV-2 virus, and the second one ran twelve months later (January 2022). Overall, respondents held higher positive emotions than negative ones towards bats in both surveys, with no significant emotional shift observed. Positive emotions positively correlated with intentions to perform bat-conservation actions, while negative emotions showed no such relationship. Although our findings might be context-specific to populations in Germany or Europe, given European-Union legislation protecting bats and their habitats, they highlight the nuanced and complicated emotions that can be associated with certain species. Understanding these emotions can guide targeted conservation strategies and public outreach. Our results caution against overly generalising discussions of biophobia in conservation.