bluuebunny/crossref_metadata_2025_split huggingface dataset:
Desmopressin for prevention of bleeding for thrombocytopenic, critically ill patients undergoing invasive procedures: A randomised, double‐blind, placebo‐controlled feasibility trial
Authors: Desborough Michael J. R. , Laing Emma , Kounali Daphne , Mora Ana , Hodge Renate , Martin Siobhan , Thomas Helen , Hudson Cara , Parsons Joseph , Shah Akshay , Hutton Paula , Parke Tim , Wise Matthew P. , Morgan Matthew , McKechnie Stuart , Stanworth Simon J. 
Published: June 2024

AbstractThrombocytopenic patients have an increased risk of bleeding when undergoing invasive procedures. In a multicentre, phase II, blinded, randomised, controlled feasibility trial, critically ill patients with platelet count 100 × 109/L or less were randomised 1:1 to intravenous desmopressin (0.3 µg/kg) or placebo before an invasive procedure. Forty‐three participants (18.8% of those eligible) were recruited, with 41 eligible for analysis. Post‐procedure bleeding occurred in one of 22 (4.5%) in the placebo arm and zero of 19 in the desmopressin arm. Despite liberal inclusion criteria, there were significant feasibility challenges recruiting patients in the critical care setting prior to invasive procedures.
Gastrectomies for the treatment of gastric cancer in a reference cancer center present better pathological results and survival compared to non‐specialized hospitals
Authors: Ramos Marcus F. K. P. , Pereira Marina A. , Santos Sarah Moreira , Dias Andre R. , Ribeiro‐Junior Ulysses 
Published: June 2024

AbstractBackgroundSome studies have shown that gastrectomy performed by experienced surgeons in high‐volume specialized hospitals with the possibility of complete treatment has better results. This study aimed to compare the results of patients who underwent surgery at a reference center with non‐specialized centers.MethodsPatients with gastric adenocarcinoma stage as pTNM II and III who underwent curative gastrectomy and were referred for adjuvant chemotherapy between 2009 and 2018 were included. Patients were divided into two groups: patients operated on in a reference center with complete oncological treatment (Reference Group); and those operated on in an external Hospital and referred for adjuvant treatment at the reference center (External Group).ResultsA total of 643 patients were evaluated, 307 in the external group and 336 in the reference group. Patients in the external group were younger (58.9 vs. 62.6 years; p < 0.001) and with fewer comorbidities according to the Charlson‐Deyo index (p < 0.001). The pathological result showed more dissected lymph nodes (41.4 vs. 23.5; p < 0.001) and a higher R0 resection rate (98.5% vs. 95.1%; p = 0.013) in the reference group. Patients of the external group underwent more adjuvant radiotherapy (49.5% vs. 33.9%; p < 0.001) with no difference concerning adjuvant chemotherapy (p = 0.066). Peritoneal recurrence was more common in the external group (63.2% vs 38.7%, p < 0.001). The disease‐free survival rate was higher in the reference group (p < 0.001) as well as overall survival (p = 0.01).ConclusionPatients who received full oncological treatment at a reference center had better survival outcomes compared to those operated in external services.
A robust ultra‐performance liquid chromatography‐tandem mass spectrometry method for simultaneous determination of 10 components in glutathione cycle
Authors: Qin Xiang‐Ling , Wang Si‐Yu , Li Qi‐Long , Wang Jun‐Jie , Yao Zhong‐Wei , Zhu Jin‐Hao , Chen Lin‐Xia , Huo Jie‐Ge , Li Song‐Lin , Zhou Jing , Zhu He 
Published: June 2024

Glutathione (GSH) is an important antioxidant that is generated and degraded via the GSH cycle. Quantification of the main components in the GSH cycle is necessary to evaluate the process of GSH. In this study, a robust ultra‐performance liquid chromatography‐tandem mass spectrometry method for the simultaneous quantification of 10 components (GSH; γ‐glutamylcysteine; cysteinyl‐glycine; n‐acetylcysteine; homocysteine; cysteine; cystine; methionine; glutamate; pyroglutamic acid) in GSH cycle was developed. The approach was optimized in terms of derivative, chromatographic, and spectrometric conditions as well as sample preparation. The unstable thiol groups of GSH, γ‐glutamylcysteine, cysteinyl‐glycine, n‐acetylcysteine, cysteine, and homocysteine were derivatized by n‐ethylmaleimide. The derivatized and underivatized analytes were separated on an amino column with gradient elution. The method was further validated in terms of selectivity (no interference), linearity (R2 > 0.99), precision (% relative standard deviation [RSD%] range from 0.57 to 10.33), accuracy (% relative error [RE%] range from ‐3.42 to 10.92), stability (RSD% < 5.68, RE% range from ‐2.54 to 4.40), recovery (RSD% range from 1.87 to 7.87) and matrix effect (RSD% < 5.42). The validated method was applied to compare the components in the GSH cycle between normal and oxidative stress cells, which would be helpful in clarifying the effect of oxidative stress on the GSH cycle.
Comparing Outcomes Between Standard Mepilex and Mepilex Silver for Tracheotomy Dressings
Authors: Marcet‐Gonzalez Jessie , Mizu Ruth K. , Brown Jennifer N. , Prasla Heena N. , Pham Tien , Ongkasuwan Julina , Lambert Elton , Raynor Tiffany , Bedwell Joshua R. 
Published: June 2024

ObjectiveThe purpose of the study is to compare the incidence of early postoperative tracheotomy stoma wound complications in pediatric patients using a silver‐impregnated barrier dressing (Mepilex Ag) versus a standard absorbent foam dressing (standard Mepilex).MethodsThis is a prospective, non‐blinded, randomized trial of pediatric patients undergoing tracheotomy at a tertiary care children's hospital. Patients were randomized to receive Mepilex Ag versus standard Mepilex tracheostoma dressings following tracheotomy. All patients received standard postoperative wound care and daily stomal examination. Wound related complications, breakdown, granulation, and infection were recorded for the first 7 days after surgery. A non‐inferiority study design was used to test the hypothesis that the Mepilex group had a non‐inferior wound complication rate (within 10% margin) compared to the Mepilex Ag group.ResultsEighty‐two patients were enrolled; 52 received Mepilex Ag, and 30 received standard Mepilex. There was no difference between the groups with respect to age, sex, race, surgical indication, or postoperative length of stay. Non‐inferiority testing demonstrated that the Mepilex standard cohort had no more than 10% greater stomal wound complication rate than that of Mepilex Ag dressing group (p = 0.0108).ConclusionStandard Mepilex was found to be non‐inferior to Mepilex Ag in the prevention of tracheotomy stomal wound complications. Standard Mepilex may be used effectively in the postoperative period, potentially reducing costs to caregivers and the institution. Further work is needed to analyze additional factors that could contribute to poor postoperative stoma healing such as bacterial colonization.Level of EvidenceRandomized Controlled Trial, 2 Laryngoscope, 134:5160–5163, 2024
Association of Hearing Loss Onset and Etiology with Psychosocial Outcomes Among US Older Adults
Authors: Gallagher Tyler J. , Jamal Malaika , Choi Janet S. 
Published: June 2024

ObjectiveUnderstand the differential association of onset and etiology of hearing loss with psychosocial outcomes among older adults.MethodsThis is a cross‐sectional cohort study based on 2017–2020 National Health and Nutrition Examination Survey. Adults aged ≥70 years who completed audiometric testing and questionnaires on onset and etiologies of hearing loss were included (n = 612). Outcomes included report of social avoidance and major depressive disorder (MDD, PHQ‐9). Multivariable regression was utilized to examine differential associations of onset and etiology of hearing loss on psychosocial outcomes while adjusting for relevant factors.ResultsIn this nationally representative sample of US older adults with hearing loss, 20.8% [95%CI: 14.5–29.0%] reported social avoidance due to hearing loss and 7.2% [95%CI: 4.3–11.8] reported symptoms suggestive of MDD. Multivariable regression demonstrated self‐reported onset of hearing loss between ages 6–19 years (OR:2.49 [95%CI: 1.52–4.10]) and 20–59 years (OR:1.95 [95%CI: 1.07–3.55]) was associated with higher avoidance of social interaction than reported onset at ≥70 years. Those with onset between 20–59 years (OR:4.28 [95%CI: 1.17–15.6]) and 60–69 years (OR:5.68 [95%CI: 1.85–17.5]) were more likely to report symptoms consistent with MDD than those with onset at ≥70. Multivariable regression did not demonstrate increased risk of avoiding social interactions or MDD due to hearing loss from noise exposure, ear infection, or ear disease versus aging alone.ConclusionThere was an association between earlier hearing loss onset with social avoidance and MDD. This suggests a need for research to investigate the impact of earlier diagnosis and intervention for hearing loss on psychosocial outcomes.Level of Evidence2b Laryngoscope, 134:5073–5079, 2024
Study of phosphorus status and sorption properties in reclaimed lignite mine soils under different age stands of Robinia pseudoacacia L. in Welzow, Germany
Authors: Hashar Mohammad Rafiul , Nasrin Shamima , Freese Dirk , Veste Maik 
Published: June 2024

AbstractDue to the open‐cast mining activities, a large area in the Lusatian region in eastern Germany was left unproductive. Robinia pseudoacacia L. was planted within different ages in that large area as a short rotation coppice for woody biomass cultivation as well as to increase soil nutrients by increasing plant phosphorous (P) availability, accumulating organic matter input and biological nitrogen fixation. In this experiment, soil chemical analysis has been done to investigate the improvement and status of P in the mining soil depending on the ages of plantation (16, 17, 18, and 27 years old) of Robinia pseudoacacia L. The results show a higher P sorption in the oldest site, and the average P sorption capacity (PSC) obtained in the oldest site was 21.0 mmol Kg−1, which was 3–4 times higher than the youngest site. However, all the values were very low compared with the optimum plant growth level, and low P desorption indicates a low level of plant‐available P in the soil. The lower sorption properties with the small amount of oxalate iron (Feox) and oxalate aluminum (Alox) indicate the general P deficiency in the soil. However, a comparison from a previous study on the same experimental areas shows that not much improvement has occurred in soil P, and the change in soil P dynamics is very low. Nevertheless, the improvement of the values with increasing ages of Robinia pseudoacacia L. indicates that further improvement may be expected in soil nutrients with time.
Luminescence Improvement of Hybrid Zinc‐Based Halides via Sb3+‐Doping for Flexible X‐Ray Imaging
Authors: Liang Dehai , Wang Meng , Zhao Shuangyi , Xu Zhiyuan , Qaid Saif M. H. , Qian Qingkai , Zang Zhigang 
Published: June 2024

AbstractRecently, zinc‐based metal halides have attracted numerous attention due to their excellent stability, low toxicity, and wide bandgaps. However, [ZnX4]2− tetrahedra in zinc‐based halides are found to be non‐optically active, which leads to poor photoluminescence quantum yields (PLQYs). Herein, Sb3+ ions are doped into hybrid zinc‐based halides of (C8H26N4)ZnCl6 single crystals (SCs) via an evaporative crystallization method. Compared with undoped (C8H26N4)ZnCl6 SCs with weak blue emission, Sb3+‐doped (C8H26N4)ZnCl6 SCs exhibit a strong broadband emission centered at 694 nm with a high PLQY of 67%, which is confirmed to be derived from self‐trapped excitons (STEs) of Sb3+ luminescent centers. Subsequently, Sb3+‐doped (C8H26N4)ZnCl6 is employed in flexible scintillation films, which demonstrates remarkable X‐ray imaging of complex objects with a spatial resolution of 3.6 lp mm−1 and a detection limit of 123.8 µGyair s−1, proving its promising potential in flexible X‐ray imaging applications.
All‐Biomass‐Based Hierarchical Photonic Crystals with Multimode Modulable Structural Colors and Morphing Properties for Optical Encryption
Authors: Ji Yue‐E , Wang Yushu , Wang Ziting , Wang Tao , Fu Yinghao , Zhu Zhenghua , Wang Yu , Ma Lingling , Lu Yanqing 
Published: June 2024

AbstractMaterials with structural coloration capable of multimode color manipulation are gaining growing significance for advanced encryption and high‐security anti‐counterfeiting applications. Among the most promising candidates are naturally derived biomaterials, owing to their renewable, biocompatible, and biodegradable features for developing sustainable, bio‐interfaced photonic platforms. Nevertheless, structural color encryption strategies developed from biological materials usually exhibit limited optical operation modes, lowering their encryption capability and security level. Here, an all‐biomass‐based photonic crystal platform is reported that hierarchically integrates chiral nematic and inverse opal structures through a combination of colloidal assembly, silk protein self‐assembly, and chiral self‐assembly of cellulose nanocrystals, enabling multiplex structural color manipulation in 2D and 3D spaces. The platform's Janus‐style integration brings specular and diffuse reflection, direction‐dependent reflection, circular dichroism, and birefringence into a single form, thereby facilitating multimode structural color tuning in a 2D plane by altering the illumination‐viewing modes. The inherent shape plasticity of silk proteins allows the subsequent creation of 3D photonic platforms with diverse configurations, offering additional spatial flexibility for color encoding. It is demonstrated that this all‐biomass‐based photonic framework exhibits versatile, multilevel, and high‐capacity encryption capability in 2D and 3D spaces, representing an innovative solution to bolster security measures against counterfeiting for future technologies.
Application of Organic Gel on Skin Realized by Hydrogel/Organic Gel Adhesion
Authors: Hu Ziqing , Tang Wei , Ji Xiaofan 
Published: June 2024

AbstractDiversity in solvent selection bestows the organic gel with appealing characteristics embracing antidrying, anti‐icing, and antifouling abilities. However, organic gel, subjected to the “toxic” inherent property of solvent, is not able to be manipulated on skin. Herein, introducing the hydrogel layer amid organic gel and skin is envisaged to realize application of organic gel on skin. Hydrogel, inserted as the medium layer, works for the coupling role between skin and organic gel, also avoids the direct contact of organic gel toward skin. First, hydrogel system composed of acrylic acid is fabricated, meanwhile organic gel is prepared employing 2‐hydroxyethyl methacrylate, ethylene glycol (EG) as solvent. Organic gel is able to adhere to hydrogel by hydrogen bonding resulting from carboxyl groups of polyacrylic acid chains and hydroxyl groups occurring on 2‐hydroxyethyl methacrylate or EG. Additionally, hydrogen bonding enables the hydrogel to be firmly attached to skin, thus organic gel/hydrogel/skin assembly is produced. The further application of organic gel is exploited by incorporating stimuli‐responsive dyes including spiropyran and rhodamine derivative.
Adaptive light intensity aided wavelength tuning for phase‐shifting interferometric measurement system
Authors: Lu Qingjie , Wang Ji , Liu Wenjing , Liu Chang 
Published: June 2024

AbstractIn phase‐shifting interferometric measurement system, using wavelength‐tuned phase‐shifting technology to measure optical surface can improve vibration errors. However, the wavelength‐tuned phase‐shifting interferometry is greatly challenged by nonlinear distortion between wavelength‐tuned light intensity and voltage modulation, which has a certain impact on phase calculation accuracy. To address this issue, an adaptive light intensity‐aided interferometric measurement scheme is proposed in this study. To improve the adjustment time of voltage response, an improved fuzzy single‐neuron adaptive proportional differential integral constant amplitude control algorithm is built. By exploiting the online detection and feedback control of light intensity, the stable output of light intensity is integrated into phase‐shifting measurement system. Experiment results verify that the improvement of light intensity fluctuation range, root mean square, and peak‐to‐valley measurement repeatability can be achieved with the proposed scheme.
Clinical and patient‐reported outcomes and neurofilament response during tofersen treatment in SOD1‐related ALS—A multicenter observational study over 18 months
Authors: Meyer Thomas , Schumann Peggy , Weydt Patrick , Petri Susanne , Weishaupt Jochen H. , Weyen Ute , Koch Jan C. , Günther René , Regensburger Martin , Boentert Matthias , Wiesenfarth Maximilian , Koc Yasemin , Kolzarek Felix , Kettemann Dagmar , Norden Jenny , Bernsen Sarah , Elmas Zeynep , Conrad Julian , Valkadinov Ivan , Vidovic Maximilian , Dorst Johannes , Ludolph Albert C. , Hesebeck‐Brinckmann Jasper , Spittel Susanne , Münch Christoph , Maier André , Körtvélyessy Péter 
Published: June 2024

AbstractIntroduction/AimsIn amyotrophic lateral sclerosis (ALS) caused by SOD1 mutations (SOD1‐ALS), tofersen received accelerated approval in the United States and is available via expanded access programs (EAP) outside the United States. This multicenter study investigates clinical and patient‐reported outcomes (PRO) and serum neurofilament light chain (sNfL) during tofersen treatment in an EAP in Germany.MethodsSixteen SOD1‐ALS patients receiving tofersen for at least 6 months were analyzed. The ALS progression rate (ALS‐PR), as measured by the monthly change of the ALS functional rating scale—revised (ALSFRS‐R), slow vital capacity (SVC), and sNfL were investigated. PRO included the Measure Yourself Medical Outcome Profile (MYMOP2), Treatment Satisfaction Questionnaire for Medication (TSQM‐9), and Net Promoter Score (NPS).ResultsMean tofersen treatment was 11 months (6–18 months). ALS‐PR showed a mean change of −0.2 (range 0 to −1.1) and relative reduction by 25%. Seven patients demonstrated increased ALSFRS‐R. SVC was stable (mean 88%, range −15% to +28%). sNfL decreased in all patients except one heterozygous D91A‐SOD1 mutation carrier (mean change of sNfL −58%, range −91 to +27%, p < .01). MYMOP2 indicated improved symptom severity (n = 10) or yet perception of partial response (n = 6). TSQM‐9 showed high global treatment satisfaction (mean 83, SD 16) although the convenience of drug administration was modest (mean 50, SD 27). NPS revealed a very high recommendation rate for tofersen (NPS +80).DiscussionData from this EAP supported the clinical and sNfL response to tofersen in SOD1‐ALS. PRO suggested a favorable patient perception of tofersen treatment in clinical practice.
How to promote geophysics as a standard tool for geotechnical investigations
Authors: Gustafsson J. , Higgs H. 
Published: June 2024

AbstractThere are a number of success stories of how geophysical investigations have been combined with geotechnical investigations to increase the knowledge of our subsurface from around the world. However, there is still a lack of understanding between these two professions, geophysicists and geotechnical engineers. The lack of understanding mainly considers what different geophysical methods deliver in form of results and accuracy. To promote the use of geophysical investigations even more, we need to address the purpose and expectations of the geophysical investigations, the awareness of method limitations and uncertainties of the different methods, and which standards and tools for interpretation and visualization are used.
A Scoping Review of Pain Management After Transoral Robotic Surgery
Authors: Snyder Vusala , Kraft Daniel O. , Creamer Andrew , Spector Matthew E. , Sridharan Shaum S. 
Published: June 2024

AbstractObjectivePain following transoral robotic surgery (TORS) is a driver of adverse outcomes and can lead to readmission and treatment delays. A scoping review was conducted to characterize TORS‐related pain and identify key management strategies utilized in the literature.Data SourcesOVID Medline, CINAHL, Cochrane, Pubmed, and Embase databases were queried.Review MethodsTwo team members independently screened titles and abstracts and completed full‐text reviews. Studies examining TORS for OPSCC with quantitative pain data were included. The study followed the PRISMA guidelines.ResultsA total of 1467 studies were imported for screening and 25 studies were ultimately included. The average study sample size was 89 participants. 68% were conducted in a single‐center academic setting. Pain was assessed on varying timelines up to 3 years using 13 different metrics. Pain peaks days‐weeks postoperatively and returns to baseline thereafter. Postoperative pain is a significant cause of morbidity and limited data exist about optimal management.ConclusionProspective studies are needed to characterize and address TORS‐related pain.
Reflexive thematic analysis of interviews with postprimary educators' experience and attitudes toward concussion
Authors: Conaghan Caomhan , Daly Ed , Ryan Lisa 
Published: June 2024

AbstractConcussions from sport and recreational activities can negatively impact academic performance in adolescents. This study aims to use reflexive thematic analysis to understand the knowledge, management, and education of concussion among Irish postprimary educators. A cross‐sectional study that involved semistructured interviews with 18 secondary school teachers was conducted. Interviews were recorded and transcribed in preparation for a reflexive thematic analysis process according to research conducted by Braun and Clarke. A total of 664 data items were coded which led to the development of 5 themes (i.e., teacher's background experience, consequences of concussion, concussion in school, educating educators, and existing standards) and 22 subthemes. The implementation of concussion education initiatives for improving student safety, injury management, and recovery through mandatory teacher‐continued professional development should be explored. Teachers' knowledge of concussion is influenced by personal experiences, with safer attitudes observed in those who have witnessed or experienced concussions. The role of the Year Head in concussion management should be explored with a focus on communication pathways and dissemination of materials. Protocols for medical emergencies and academic adjustments for concussed students should be made readily available to secondary school teachers.
Decision‐making regarding safety investments: A case study of fluidized‐bed reactors
Authors: Sano Kazuhiko , Koshiba Yusuke 
Published: June 2024

AbstractIn chemical plants, the pressure to prioritize production and minimize operating costs often leads to delays in safety investments. To allocate limited management resources effectively, decision‐making regarding safety investments must follow a logical approach. This article outlines how engineers can provide valuable information to the management, enabling them to make informed decisions. We demonstrate that decision‐making involves both technical and economic considerations, following a well‐defined process with distinct stages. This study highlights the importance of technical data in making informed decisions regarding safety investments. Decision makers must consider various factors, including risk assessment, economic efficiency, technology reliability, and construction safety. In addition, economic efficiency considerations should incorporate new proposals that account for environmental profit/loss. Our findings confirm that effectiveness of the proposed method, particularly when applied to fluidized‐bed reactors. In conclusion, accurate allocation of management resources at appropriate times leads to reasonable risk reduction.