bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short-term outcomes after elective minimally invasive colectomy for diverticulitis
Authors: Pendlimari R , Touzios J G , Azodo I A , Chua H K , Dozois E J , Cima R R , Larson D W 
Published: November 2010

Abstract

Background
The role of minimally invasive surgery in complicated diverticulitis is still being elucidated. The aim of this study was to compare short-term outcomes in patients undergoing minimally invasive surgery for complicated or uncomplicated diverticular disease.

Methods
All patients who had elective minimally invasive surgery for diverticulitis between 2003 and 2008 were identified from a prospectively maintained database. Complicated disease was defined as diverticulitis associated with abscess, fistula, stricture or bleeding. Univariable analysis was performed to compare safety and short-term outcomes in patients with complicated and uncomplicated diverticulitis.

Results
A total of 361 patients (136 with complicated and 225 with uncomplicated diverticulitis) were operated on with either a laparoscopic (36·0 per cent) or a hand-assisted laparoscopic (64·0 per cent) surgical technique. There were no significant differences between the groups with respect to age, sex, body mass index, laparoscopic approach, postoperative recovery protocol or previous open surgery. Conversion rates were similar for complicated and uncomplicated disease (14·0 versus 11·6 per cent respectively; P = 0·514). There was no difference between the groups with respect to return of bowel function (mean 3·1 versus 3·2 days respectively; P = 0·156), morbidity (27·9 versus 19·6 per cent; P = 0·070) or mean length of stay (5·4 versus 4·8 days; P = 0·186). There were no deaths within 30 days.

Conclusion
Elective minimally invasive colectomy is feasible for patients with uncomplicated and complicated diverticulitis, with equivalent outcomes.
Cationic Peptides that Increase the Thermal Stabilities of 2′‐O‐MeRNA/RNA Duplexes but Do Not Affect DNA/DNA Melting
Authors: Murtola Merita , Zaramella Simone , Yeheskiely Esther , Strömberg Roger 
Published: November 2010

AbstractSeveral different cationic nonapeptides have been synthesized and investigated with respect to how they can influence the thermal melting of 2′‐O‐methylRNA/RNA and DNA/DNA duplexes. Each peptide has a C‐terminal L‐phenylalanine unit and is otherwise uniformly composed of a sequence of a specific basic D‐amino acid that in most cases will be largely charged at neutral pH. These N‐terminal octamer stretches are composed variously of the amino acids D‐lysine, D‐diaminobutyric acid (D‐Dab), D‐diaminopropionic acid (D‐Dap), or D‐histidine. None of the peptides substantially affected the thermal melting of DNA/DNA duplexes, which was in sharp contrast with their effects on 2′‐O‐methylRNA/RNA duplexes. In particular, the peptides based on diaminopropionic and diaminobutyric acid units had strong positive effects on the melting temperatures of the 2′‐O‐methylRNA duplexes (up to 16 °C higher with 1 equivalent of peptide) at pH 7, whereas at pH 6 the effect was even more drastic (ΔTm up to +25 °C). The shorter R groups of the Dap and Dab groups appear to have a better length than lysine for enhancement of the thermal melting of the 2′‐O‐methylRNA/RNA duplex, an effect that is more pronounced at lower pH but substantial even at pH 7, although the Dap derivative is not likely to be fully protonated. The dramatic difference between the influence, or lack thereof, on the 2′‐O‐methylRNA/RNA and the DNA/DNA thermal meltings suggest that, although electrostatic interactions probably play a role, there is another major and structurally dependent component influencing the properties of the duplexes. This is also seen in the observation that the oligo‐Dap and oligo‐Dab peptides give greater melting point enhancements than both the lysine peptide (with a longer side chain) and a β‐linked Dap peptide with a shorter side chain and a longer backbone.
Options for the Treatment and Management of Municipal Landfill Leachate: Common and Specific Issues
Authors: Schiopu Ana‐Maria , Gavrilescu Maria 
Published: November 2010

AbstractThis paper aims to explore information from the literature for emphasizing the state‐of‐the art and progress in landfill leachate generation, fate and migration, and treatment. Leachate composition is discussed in terms of types of waste disposed and the processes occurring within landfill. The focus is also on potential pathways of environmental contamination by leachate, which may increase environmental and human health risk. The analysis addresses the opportunity and support for decision making concerning alternatives for leachate management and treatment. Advantages and limitations of treatment methods and processes are discussed considering leachate transfer, physico‐chemical methods, biodegradation, and combined methods.
Influence of Hydrogen Bonds and Nonspecific Interactions on the Spectral and Photophysical Properties of the Excited Singlet States of 4‐Aminophthalimide in Amine Solution
Authors: Maciejewski Andrzej , Krystkowiak Ewa , Koput Jacek , Dobek Krzysztof 
Published: November 2010

AbstractThe hydrogen‐bond and nonspecific interaction energies for 4‐aminophthalimide (4‐AP), often used as a probe, in the ground electronic and excited singlet states are determined using ab initio computational methods. It is shown that the 4‐AP molecule can form three relatively strong hydrogen bonds with trimethylamine (TMA) and triethylamine (TEA), which leads to the formation of S0‐complexes between the solute and solvent molecules. Only two of the hydrogen bonds with the amine group of 4‐AP change significantly their energies upon excitation and deactivation. The theoretical results are necessary to explain the spectral and unusual photophysical properties of 4‐AP in amine solutions.
Electrical and optical properties of Co doped TlGaS2 crystals
Authors: Karabulut O. , Yilmaz K. , Boz B. 
Published: November 2010

AbstractIn this study, Co doped TlGaS2 single crystals which belongs to the class of AIIIBIIIX2VI have been investigated by means of XRD, temperature dependent dark and illuminated conductivity, Space Charge Limited Currents and absorption measurements. The room temperature conductivity and trap concentration values were about 10‐8 (Ω‐cm)‐1 and 7.5 × 1013 cm‐3, respectively. From the temperature dependent conductivity measurements, two activation energies namely 271 and 12 meV have been determined in the high and low temperature regions, respectively. The trap level at 271 meV that was determined by the dark temperature dependent conductivity measurement has also been verified by Space Charge Limited Currents analysis. The absorption measurements have showed that the layered compound had indirect and direct band gaps and the values were determined to be 2.49 and 2.56 eV, respectively. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Nickel(II) and Cobalt(II) 3‐Hydroxy‐4‐pyridinone Complexes: Synthesis, Characterization and Speciation Studies in Aqueous Solution
Authors: Queiros Carla , Amorim M. João , Leite Andreia , Ferreira Monica , Gameiro Paula , de Castro Baltazar , Biernacki Krzysztof , Magalhães Alexandre , Burgess John , Rangel Maria 
Published: November 2010

AbstractThe interaction of nickel(II) and cobalt(II) with a set of 3‐hydroxy‐4‐pyridinone ligands (Hmpp, Hmepp, Hetpp, Hempp, Hdepp and Hdmpp) was investigated in aqueous solution. The family of chelators under study is pharmaceutically relevant in the treatment of iron‐overloaded patients and it is foreseen to be of use in occupational health situations associated with accumulation of nickel and cobalt such as nasal/pulmonary and skin hazards and allergies. Ligand dissociation constants and stability constants for the cobalt(II) and nickel(II) complexes have been determined by potentiometric methods allowing the establishment of the corresponding speciation plots as a function of pH. The values of the stability constants are consistent with the Irving–Williams series and indicate the formation of stable ML2 complexes which were isolated and characterized. Following the trend observed for 3‐hydroxy‐4‐pyridinone ligands the solids were obtained as hydrates whose composition was characterized as [ML2(H2O)2]·xH2O complexes. DFT calculations allowed geometry optimization and provided information about bond lengths and angles.
Recent advances in the MS analysis of glycoproteins: Capillary and microfluidic workflows
Authors: Cortes Diego F. , Kabulski Jarod L. , Lazar Alexandru C. , Lazar Iulia M. 
Published: November 2010

AbstractRecent developments in bioanalytical instrumentation, MS detection, and computational data analysis approaches have provided researchers with capabilities for interrogating the complex cellular glycoproteome, to help gain a better insight into the cellular and physiological processes that are associated with a disease and to facilitate the efforts centered on identifying disease‐specific biomarkers. This review describes the progress achieved in the characterization of protein glycosylation by using advanced capillary and microfluidic MS technologies. The major steps involved in large‐scale glycoproteomic analysis approaches are discussed, with special emphasis given to workflows that have evolved around complex MS detection functions. In addition, quantitative analysis strategies are assessed, and the bioinformatics aspects of glycoproteomic data processing are summarized. The developments in commercial and custom fabricated microfluidic front‐end platforms to ESI‐ and MALDI‐MS instrumentation, for addressing major challenges in carbohydrate analysis such as sensitivity, throughput, and ability to perform structural characterization, are further evaluated and illustrated with relevant examples.
Thermophilic digestion of cellulose at high‐organic loading rates
Authors: Golkowska Katarzyna , Greger Manfred 
Published: November 2010

AbstractThe influence of high punctual organic loadings on performance of anaerobic biocenosis was examined. Thermophilic batch series with microcrystalline cellulose at six organic loading rates (OLRs) were performed (5.7–34.3 kg VS/m3). With the loading increase and exceeding of recommended substrate/inoculum ratio of 0.5 for volatile solids, an inhibitory state was targeted. Although extreme OLRs had been applied, they did not lead to the permanent acidosis. The only explicit sign of system stress was the increasing total degradation time and the extended period of higher biogas production rate with every increase of OLR. Measured fermentation parameters (pH, oxidation–reduction potential, volatile acids and acids/buffer capacity ratio) were changed simultaneously during fermentation. A clear system evaluation was not possible with any of these parameters without gas production. This confirms gas production as the first and most important control parameter for the supervision of the fermenting process. Also, propionic/acetic acid ratio as well as C4‐C5 fatty acids delivered only ambiguous results. Even significant exceeding of limits given by the literature did not result in extreme system performance. The observed signs of system stress were not proportional to the applied OLRs. They resulted from hydrolysis or acetogenesis rate delay. In addition, they prove a much higher than expected adaptation level of microbial biocenosis to increasing OLR if the loads are introduced gradually.
Use of zeolite to alleviate water stress on subsurface drip irrigated barley under hot environments
Authors: AL‐Busaidi Ahmed , Yamamoto Tahei , Tanigawa Torahiko , Rahman Hayder Abdel 
Published: November 2010

AbstractWater stress is the primary environmental factor that limits cereal production in Mediterranean environments, where barley (Hordeum vulgare L.) is one of the main crops. This investigation aimed at evaluating the effects of zeolite on barley growth under subsurface drip irrigation, subjected to water and heat stress. A sand dune soil was amended with Ca‐type zeolite and irrigated every 2nd, 3rd, 4th and 5th day. The results showed that zeolite application significantly increased water‐holding capacity of the soil and improved plant growth. Using subsurface irrigation with zeolite amendment helped to reduce water evaporation, kept more water in lower horizons, encouraged salt leaching, and the plants used water more efficiently. Plant growth parameters showed significant differences among treatments and were negatively affected by heat and water stress conditions. High temperatures caused accelerated evapotranspiration, water stress in plants and faster depletion of water from the root zone, causing substantial water loss and inducing water deficit conditions in plants. Using subsurface irrigation poses a better option for the reduction of evaporation and achieving higher water use efficiency. Application of zeolite together with subsurface irrigation may provide favorable conditions for crop production in water‐scarce areas under warm environments. Copyright © 2010 John Wiley & Sons, Ltd.
The flawed interview of a psychopathic killer: what went wrong?
Authors: Perri Frank S. 
Published: November 2010

AbstractThe flawed interview of convicted killer Christopher Porco illustrates what occurs when a suspect's psychopathic traits are not considered in formulating an interview strategy. Specific areas of the dialogue between Christopher Porco and law enforcement demonstrates that traditional methods of interviewing may not produce a confession or valuable information when it comes to psychopathic suspects. Although the traditional goal of an interview is to obtain a confession or valuable information, law enforcement will have to display flexibility in the interview process by implementing alternative interview strategies and redefining what a successful interview is composed of when these suspects are unwilling to confess to their crimes. Failure to remain flexible, as displayed in the Christopher Porco case, which yielded neither a confession nor valuable information, can jeopardise the strength of a homicide case that ultimately may go to trial. Copyright © 2010 John Wiley & Sons, Ltd.
Intra‐individual variation in stable carbon (δ13C) and nitrogen (δ15N) isotopes in mandibles of modern caribou of Qamanirjuaq (Rangifer tarandus groenlandicus) and Banks Island (Rangifer tarandus pearyi): Implications for tracing seasonal and temporal changes in diet
Authors: Drucker D.G. , Hobson K.A , Münzel S.C. , Pike‐Tay A. 
Published: November 2010

ABSTRACTIntra‐individual variations in carbon (δ13C) and nitrogen (δ15N) isotope measurements of dentine collagen in ungulate teeth can be related to diet and environmental changes at different periods during the life of the animal. A protocol of serial sampling of first, second and third molar roots was applied to modern caribou (17–27 months old) of the Qamanirjuaq herd (Rangifer tarandus groenlandicus), Canada. Based on a previous study, we predicted that M2 would reflect winter, M3 summer and M1 a complete year in terms of the isotopic record. Relatively high δ15N values (ca. 6 to 8‰), previously attributed to winter stress, were found in different molars of different specimens, reflecting a period of growth between April 1966 to April 1967. Previous results on other teeth from the same population confirmed that a high δ15Ncoll value signal corresponded to the winter of 1966/67. This temporary increase in δ15N value was probably linked to diet and/or environmental change. Collagen from M1 reflects the first winter whereas M2 and M3 reflect the second winter of life of young caribou. A longer time record including summer is represented by the bone collagen of the mandible. Results obtained on molar roots and mandible bone of the modern caribou of Banks Island herd (Rangifer tarandus pearyi) confirmed this seasonal record. Such collagen isotopic analysis on M1, M2 and M3 roots and jawbone can be applied to reindeer found in archaeological sites. Mandibles retaining deciduous premolars are preferable to avoid the possible loss of the winter tooth signal observed in animals older than 2 years. Copyright © 2010 John Wiley & Sons, Ltd.
Amplification and overexpression of vinculin are associated with increased tumour cell proliferation and progression in advanced prostate cancer
Authors: Ruiz Christian , Holz David R , Oeggerli Martin , Schneider Sandra , Gonzales Irma M , Kiefer Jeffrey M , Zellweger Tobias , Bachmann Alexander , Koivisto Pasi A , Helin Heikki J , Mousses Spyro , Barrett Michael T , Azorsa David O , Bubendorf Lukas 
Published: November 2010

AbstractAndrogen withdrawal is the standard treatment for advanced prostate cancer. Although this therapy is initially effective, nearly all prostate cancers become refractory to it. Approximately 15% of these castration‐resistant prostate cancers harbour a genomic amplification at 10q22. The aim of this study was to explore the structure of the 10q22 amplicon and to determine the major driving genes. Application of high‐resolution array‐CGH using the 244k Agilent microarrays to cell lines with 10q22 amplification allowed us to narrow down the common amplified region to a region of 5.8 megabases. We silenced each of the genes of this region by an RNAi screen in the prostate cancer cell lines PC‐3 and 22Rv1. We selected genes with a significant growth reduction in the 10q22 amplified cell line PC‐3, but not in the non‐amplified 22Rv1 cells, as putative target genes of this amplicon. Immunohistochemical analysis of the protein expression of these candidate genes on a tissue microarray enriched for 10q22 amplified prostate cancers revealed vinculin as the most promising target of this amplicon. We found a strong association between vinculin gene amplification and overexpression (p < 0.001). Further analysis of 443 specimens from across all stages of prostate cancer progression showed that vinculin expression was highest in castration‐resistant prostate cancers, but negative or very low in benign prostatic hyperplasia (p < 0.0001). Additionally, high tumour cell proliferation measured by Ki67 expression was significantly associated with high vinculin expression in prostate cancer (p < 0.0001). Our data suggest that vinculin is a major driving gene of the 10q22 amplification in prostate cancer and that vinculin overexpression might contribute to prostate cancer progression by enhancing tumour cell proliferation. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Infection with human immunodeficiency virus‐1 (HIV) among children with cancer in South Africa
Authors: Stefan D. Cristina , Wessels Glynn , Poole Janet , Wainwright Linda , Stones David , Johnston W. Tom , Newton Robert 
Published: November 2010

AbstractBackground In adults,HIV increases the risk of certain cancers known, or thought, to have an underlying infectious etiology; the impact on the risk of cancer in children is less clear.MethodsHere, we report results of an on‐going study at four pediatric oncology centers in South Africa in which children diagnosed with cancer are tested routinely for HIV. Odds ratios (OR) for the prevalence of various malignancies were calculated (with adjustment for age, sex, and center) for the children infected with HIV using all children with cancer and non‐malignant conditions, but not infected with HIV, as a comparison group.ResultsOf 882 children with cancer, 38 were HIV infected (for 12 the HIV status was unknown). HIV was associated with Kaposi sarcoma (all 10 cases were HIV infected; P < 0.001) and with Burkitt lymphoma (OR = 46.2, 95% confidence interval (CI) 16.4–130.3; 13/33). For non‐Burkitt non‐Hodgkin lymphoma (NHL), 2/39 were HIV infected (OR = 5.0, 95% CI 0.9–27.0). No other cancer type was significantly associated with HIV, including lymphoid leukemias (OR = 0.4, 95% CI 0.04–2.9; 1/172).ConclusionsOnly Kaposi sarcoma and Burkitt lymphoma were significantly associated with HIV infection although results for non‐Burkitt NHL were suggestive. Notably, we did not identify an association between infection with HIV and lymphoid leukemias, for which an underlying infectious etiology has been suggested. Pediatr Blood Cancer. 2011;56:77–79. © 2010 Wiley‐Liss, Inc.
3‐Morpholinosydnonimine participates in the attenuation of neointima formation via inhibition of annexin A2‐mediated vascular smooth muscle cell migration
Authors: Won Kyung‐Jong , Lee Philyoung , Jung Seung Hyo , Jiang Xiaowen , Lee Chang‐Kwon , Lin Hai Yue , Kang Hyun , Lee Hwan Myung , Kim Junghwan , Toyokuni Shinya , Kim Bokyung 
Published: November 2010

Abstract3‐Morpholinosydnonimine (SIN‐1) affects vascular smooth muscle cell migration and proliferation, processes essential for atherosclerosis. However, the mechanism by which SIN‐1 exerts these effects has not been elucidated. We used 2‐DE followed by MALDI‐TOF/TOF MS to identify responses in protein expression to SIN‐1 in rat aortic smooth muscle. Platelet‐derived growth factor‐BB increased cell migration and proliferation in rat aortic smooth muscle cells, and subsequent SIN‐1 treatment inhibited it. Administration of SIN‐1 in vivo attenuated neointima formation in balloon‐injured rat carotid arteries. Proteomic analysis showed that glutathione peroxidase and 40S ribosomal protein S12 were differentially expressed in aortic strips exposed to SIN‐1. Expression of annexin A2 was decreased by SIN‐1. Platelet‐derived growth factor‐BB‐induced cell migration was increased and inhibited in rat aortic smooth muscle cells with overexpression and knockdown of annexin A2 gene, respectively. The expression of annexin A2 was increased in vascular neointima compared with the intact control, which was inhibited by SIN‐1 treatment. These results demonstrate that SIN‐1 may attenuate vascular neointima formation by inhibiting annexin A2‐mediated migration. Therefore, annexin A2 may be a potential target for therapeutic strategies for atherosclerosis.
Morphinome – A meta‐analysis applied to proteomics studies in morphine dependence
Authors: Bodzon‐Kułakowska Anna , Kułakowski Konrad , Drabik Anna , Moszczynski Adam , Silberring Jerzy , Suder Piotr 
Published: November 2010

AbstractThis review is a meta‐analysis of data describing proteins regulated by morphine influence studied worldwide across last years administration. Up to date (July 2010), 15 studies concerning this subject have been published. Animal models, examined brain structures, the route of morphine administration and proteomic platforms used for identification of differentially expressed proteins were described. Standardization of obtained results allowed for creation of database of proteins, whose expression was altered by morphine administration (www.addiction‐proteomics.org). Their analysis by tools available in Celera Panther Database was possible too. Proteins, which seem to be the most promising candidates for further research, due to their consistent appearance in different studies, were indicated. Created database may facilitate further studies by providing a possibility to compare results obtained during different experiments. At the end, dynamic picture of proteome after morphine administration, which emerges from the obtained results, is discussed and need for standardization of proteomics experiments is stressed. As meta‐analysis is a very powerful tool for evaluation and comparison of multiple data. We believe this approach will be useful in the nearest future to extract vital information from a vast number of similar publications. Morphinome database created already by our group is a comfortable tool for validation and verification of new data received after morphine influence on proteomes investigations. It gives a chance for fast comparison of results without hours spent on life science literature mining.