bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nephrology referral slows the progression of chronic kidney disease, especially among patients with anaemia, diabetes mellitus, or hypoalbuminemia: A single‐centre, retrospective cohort study
Authors: Ide Atsuki , Ota Keisuke , Murashima Miho , Suzuki Kodai , Kasugai Takahisa , Miyaguchi Yuki , Tomonari Tatsuya , Ono Minamo , Mizuno Masashi , Hiratsuka Maki , Kawai Takeshi , Suzuki Takashi , Murakami Kazutaka , Hamano Takayuki 
Published: May 2024

AbstractBackgroundThe Kidney Disease Improving Global Outcomes guidelines recommend nephrology referral for patients with chronic kidney disease (CKD) stages 4 to 5, significant proteinuria and persistent microscopic haematuria. However, the recommendations are opinion‐based and which patients with CKD benefit more from nephrology referral has not been elucidated.MethodsIn this retrospective cohort study, patients referred to our nephrology outpatient clinic from April 2017 to March 2019 were included. We excluded patients considered to have an acute decline in kidney function (annual decline in estimated glomerular filtration rate [eGFR] >10 mL/min/1.73 m2). The slopes of eGFR before and after nephrology referral were estimated and compared by linear mixed effects models. Interaction between time and referral status (before or after referral) was assessed and effect modifications by the presence of diabetes, proteinuria (defined by urine dipstick protein 2+ or more), urine occult blood, hypoalbuminemia (defined by albumin levels less than 3.5 g/dL) and anaemia (defined by haemoglobin levels less than 11.0 g/dL) were evaluated.ResultsThe eGFR slope significantly improved from −2.05 (−2.39 to −1.72) to −0.96 (−1.36 to −0.56) mL/min/1.73 m2/year after nephrology referral (p < .001). The improvement in eGFR slope was more prominent among those with diabetes mellitus, anaemia, and hypoalbuminemia (all p‐values for three‐way interaction <.001 after adjustment for covariates). Further adjustments for time‐dependent haemoglobin levels, the use of erythropoiesis‐stimulating agents, iron supplementation, anti‐hypertensives and anti‐diabetic medications did not change the significance of the interactions.ConclusionsNephrology referral slows CKD progression, especially among those with hypoalbuminemia, diabetes or anaemia. Patients with hypoalbuminemia, diabetes or anaemia might benefit more from specialized care and lifestyle modifications by nephrologists. The inclusion of anaemia and hypoalbuminemia in nephrology referral criteria should be considered.image
Food insecurity during pregnancy in high‐income countries, and maternal weight and diet: A systematic review and meta‐analysis
Authors: Nguyen Giang , Bell Zoë , Andreae Gemma , Scott Stephanie , Sermin‐Reed Letitia , Lake Amelia A. , Heslehurst Nicola 
Published: May 2024

SummaryFood insecurity is a well‐established obesity driver. Less is known about food insecurity during pregnancy. This review (PROSPERO:CRD42022311669) aimed to explore associations between food insecurity, maternal obesity, gestational weight gain (GWG), and nutrition. Searches included seven databases, gray literature, references, citations, and contacting authors. Observational studies reporting data from January 1st, 2008 to 21 November 2023 in high‐income countries were included. Duplicate screening, data extraction, and quality assessments were performed. Random effects meta‐analysis estimated odds ratios (OR), mean difference (MD), and 95% confidence intervals (CI). Narrative synthesis was conducted when data could not be pooled. Database searches identified 22,272 results; 20 studies were included (n = 19 North America, n = 1 Europe; n = 32,803 women). Food insecurity significantly increased obesity (OR 1.53 95%CI 1.39, 1.66), but not underweight (OR 1.12 95%CI 0.89, 1.34) or overweight (OR 1.18 95%CI 0.90, 1.46). Food insecurity significantly reduced GWG (MD ‐0.42 kg 95%CI ‐0.62, −0.22) and increased inadequate GWG (OR 1.16 95%CI 1.05, 1.28), but not excessive GWG (OR 1.04 95%CI 0.96, 1.13). Diet outcomes were inconsistent, with some evidence of reduced vitamin E and diet quality and increased red/processed meat consumption. Further studies outside of North America are needed to inform practice and policy to support maternal health.
A cleaved adhesin DNA vaccine targeting dendritic cell against Porphyromonas gingivalis–induced periodontal disease
Authors: Fan Xin , Qu Peng‐Yu , Luan Ke‐Feng , Sun Chen‐Yu , Ren Hui‐Ping , Sun Xue‐Hui , Lan Jing 
Published: May 2024

AbstractBackgroundArg‐gingipain A (RgpA) is the primary virulence factor of Porphyromonas gingivalis and contains hemagglutinin adhesin (HA), which helps bacteria adhere to cells and proteins. Hemagglutinin's functional domains include cleaved adhesin (CA), which acts as a hemagglutination and hemoglobin‐binding actor. Here, we confirmed that the HA and CA genes are immunogenic, and using adjuvant chemokine to target dendritic cells (DCs) enhanced protective autoimmunity against P. gingivalis–induced periodontal disease.MethodsC57 mice were immunized prophylactically with pVAX1‐CA, pVAX1‐HA, pVAX1, and phosphate‐buffered saline (PBS) through intramuscular injection every 2 weeks for a total of three administrations before P. gingivalis–induced periodontitis. The DCs were analyzed using flow cytometry and ribonucleic acid sequencing (RNA‐seq) transcriptomic assays following transfection with CA lentivirus. The efficacy of the co‐delivered molecular adjuvant CA DNA vaccine was evaluated in vivo using flow cytometry, immunofluorescence techniques, and micro‐computed tomography.ResultsAfter the immunization, both the pVAX1‐CA and pVAX1‐HA groups exhibited significantly elevated P. gingivalis–specific IgG and IgG1, as well as a reduction in bone loss around periodontitis‐affected teeth, compared to the pVAX1 and PBS groups (p < 0.05). The expression of CA promoted the secretion of HLA, CD86, CD83, and DC‐specific intercellular adhesion molecule‐3‐grabbing non‐integrin (DC‐SIGN) in DCs. Furthermore, the RNA‐seq analysis revealed a significant increase in the chemokine (C–C motif) ligand 19 (p < 0.05). A notable elevation in the quantities of DCs co‐labeled with CD11c and major histocompatibility complex class II, along with an increase in interferon‐gamma (IFN‐γ) cells, was observed in the inguinal lymph nodes of mice subjected to CCL19‐CA immunization. This outcome effectively illustrated the preservation of peri‐implant bone mass in rats afflicted with P. gingivalis–induced peri‐implantitis (p < 0.05).ConclusionsThe co‐administration of a CCL19‐conjugated CA DNA vaccine holds promise as an innovative and targeted immunization strategy against P. gingivalis–induced periodontitis and peri‐implantitis.
Clinical Study of a Four‐Step Program for the Treatment of Plantar Fasciitis with Bone Spurs
Authors: Jiang Lu , Liu Tianyu , Li Zhenyi , Tang Zihui , Zhou Xin , Xiong Bin , Zhang Lei 
Published: May 2024

ObjectiveThe most common causes of plantar and heel pain are plantar fasciitis and calcaneal spurs, and they often co‐exist. Surgery is a recognized treatment for refractory plantar fasciitis. However, few studies have proposed treatment options for patients with metatarsophalangeal fasciitis with bone spurs. Accordingly, this study's purpose was to propose a four‐step surgical regimen, and to improve the surgical outcome of plantar fasciitis with osteophytes and to establish a procedure for surgical treatment.MethodsRetrospective analysis of 45 patients suffering from plantar fasciitis with bone spurs from 2020 to 2023. All patients underwent a four‐step procedure, including plantar fascia release, calcaneal spur grinding, inflammatory tissue removal, and calcaneal burr decompression. The imaging parameters and functional scores were recorded before and after the operation. The objective evaluation included the measurement of calcaneal spur length on radiographs. Clinical evaluation included the American Orthopaedic Foot and Ankle Society (AOFAS), the Visual Analog Scale (VAS), and the Foot and Ankle Outcome Scale (FAOS). Measurement data that conformed to normal distribution were expressed as (x2 ± s), and pre‐and postoperative AOFAS, FAOS, and VAS scores were compared using repeated‐measures ANOVA, and preoperative and postoperative spur lengths were compared using paired t‐tests.ResultsThe 45 patients were followed up for 3 to 30 months, (17.72 ± 8.53) months, at final follow‐up, the patient's AOFAS score improved from preoperative (74.93 ± 5.56) to (94.78 ± 3.98), FAOS score increased from preoperative (76.42 ± 3.37) to (96.16 ± 2.74), the VAS score decreased from (3.18 ± 0.54) to (1.07 ± 1.20) (p < 0.05), the length of spur decreased from (0.72 ± 1.81) cm to (0.23 ± 1.19) cm, and there were significant differences before and after operation (p < 0.05).ConclusionThe four‐step surgical regimen is an appropriate and effective surgical procedure to treat plantar fasciitis with bone spurs.
Effectiveness of implementing a standardized perioperative pain management protocol in children undergoing tonsillectomy: A quality improvement project
Authors: Freedman Lauren , Varughese Anna , Koirala Binu , Pandian Vinciya 
Published: May 2024

AbstractBackground and PurposeTonsillectomy procedures are commonly performed worldwide. At our academic tertiary care facility, we perform approximately 1000 tonsillectomy procedures annually. We have found inconsistent pain management strategies in pediatric tonsillectomy patients have contributed to variability in postoperative complications and the number and types of postoperative pain medications required in the Post Anesthesia Care Unit (PACU). This project aimed to assess the impact of implementing a standardized perioperative pain management protocol on reducing postoperative complications in pediatric patients who underwent a tonsillectomy procedure.MethodsA pre‐post‐intervention design was utilized, comparing characteristics and outcomes of pediatric patients for whom a standardized perioperative pain management protocol was implemented over a 12‐week period compared to those who did not. The standardized perioperative pain management protocol was utilized intraoperatively by the anesthesiologists, nurse anesthetists, and residents. A Qualtrics survey was used by the Post Anesthesia Care Unit (PACU) nurses to gather data as they cared for patients who underwent tonsillectomy. Four outcomes were measured: (1) postoperative pain medication administration, (2) rate of postoperative respiratory complications, (3) rate of adherence, and (4) usability of a standardized pain management protocol. Data were compared between pre and post‐implementation groups.ResultsDuring the quality improvement project, 180 children underwent tonsillectomy, with 81 in the control group and 99 in the intervention group. The median age did not differ between groups. The control group had higher postoperative opioid medication usage (93.8% vs. 54.5%) and a higher number of opioids administered in the recovery room. Postoperative IV fentanyl was reduced in the intervention group (49.4% vs. 28.3% in the intervention, p = .004). Respiratory interventions were more frequent in the control group (24.7% vs. 7.1%), with increased respiratory team activation. Respiratory team activation in the Post Anesthesia Care Unit (PACU) includes a 511 page for anesthesia provider assistance. Respiratory interventions included bag‐mask ventilation, lidocaine, propofol or succinylcholine administration, and reintubation. The intervention group had 100% adherence to the pain management protocol, and providers found it easy to use.ConclusionThe quality improvement project highlighted notable improvements in the intervention group for whom a standardized perioperative pain management protocol was used, including reduced opioid medication administration, lower incidence of respiratory interventions, and high adherence to the pain management protocol. These findings underscore the effectiveness and feasibility of standardized protocols in enhancing patient outcomes.
CRISPR/Cas9 edited SlGT30 improved both drought resistance and fruit yield through endoreduplication
Authors: Lv Hongmei , Wang Xuewei , Dong Xiaonan , Gao Ming , Dong Danhui , Li Chonghua , Jing Shirui , Guo Yang‐Dong , Zhang Na 
Published: May 2024

AbstractThere is often a trade‐off effect between different agronomic traits due to gene pleiotropy, leading to a negative correlation between yield and resistance. Consequently, using gene‐editing techniques to develop superior traits becomes challenging. Genetic resources that defy this constraint are scarce but hold great potential as targets for improvement through the utilisation of CRISPR. Transcription factors are critical in modulating numerous gene expressions across diverse biological processes. Here, we found that the trihelix transcription factor SlGT30 plays a role in drought resistance and tomato fruit development. We edited the SlGT30 gene with CRISPR/Cas9 technology and found that the knockout lines showed decreased stomata density in the leaves and large fruits. Subsequent examination revealed that cell ploidy was impacted in the leaves and fruits of SlGT30 knockout lines. SlGT30 knockout affected cell size through the endoreduplication pathway, manifested in decreased stomata density and reduced water loss. Consequently, this resulted in an enhancement of drought resistance. For the fruit, both cell size and cell number increased in the fruit pericarp of knockout lines, improving the fruit size and weight accordingly. Therefore, SlGT30 represents a promising candidate gene for gene editing in breeding practice.
Recent advances of Terminalia catappa and its application in fish culture: A review
Authors: Wang Xu , Taufek Norhidayah Mohd , Arshad Norhafiza Mohd 
Published: May 2024

AbstractHigh‐intensity aquaculture may cause the aquatic animals to experience elevated stress levels, which in turn will increase their susceptibility to illness and result in substantial losses. Farmers frequently use chemical and antibiotic treatments for fish diseases, which have led to drug‐resistant and hazardous residues in farmed fish and the environment. Consequently, finding substitutes for chemicals and antibiotics is crucial for disease management in aquaculture. Terminalia catappa L. or commonly called Indian almond is well known for its medicinal properties and widely distributed in tropical and subtropical regions. T. catappa contains chemical compounds such as tannin and flavonoid that play an important role in antibacterial, anti‐allergy, anti‐inflammation, and anti‐cancer. Numerous studies have been conducted on leaves, bark, fruits, and seed of T. catappa for their applications, including medicinal, bioremediation (dye absorption), and aquaculture use. Much research can be found on the utilization of T. catappa leaves to improve fish well‐being, mostly in the ornamental fish industry. Extract of T. catappa has been found to improve fish survival, growth rate, inhibit bacterial infection, improve water quality, enhance fish colouration, and boost the immune response. Although T. catappa leaves have undergone substantial research, it has not been systematically described in connection to fish species used in aquaculture. This review will systematically discuss the biotoxicity of T. catappa evaluation of growth‐promoting properties, eggs and larviculture performance, and enhancement of fish resistance to various bacteria, fungi, and parasites. In addition, the article also highlights the future perspectives of using T. catappa to improve fish culture.
A review of the benefits and limitations of waste nutrient treatment in aquaculture pond facilities
Authors: Tabrett Simon , Ramsay Ian , Paterson Brian , Burford Michele A. 
Published: May 2024

AbstractManaging waste nutrients from intensive freshwater and marine pond aquaculture is a global challenge. Nutrient‐enriched water released from farms can have detrimental effects on aquatic ecosystem health. There are a range of treatment options for discharge water from fish and crustacean ponds, and this review examines the benefits and limitations of these options. Much of the nutrient waste is derived from the addition of formulated feed. In recent years, reduction in waste from feeds and feeding has been largely incremental. In terms of treatment, there are low‐cost approaches, such as settlement ponds, but they are inefficient at reducing nutrients. Biological systems, using aquatic plants, microalgae and filter feeders to reduce nutrient release from farms have variable levels of effectiveness. Establishing wetlands requires considerable additional land area, and success to date has been highly variable. Overall, this review found no simple cost‐effective solution for managing nutrient enriched water from ponds. This is due, in many cases, to challenges with treating the large volumes of discharge water with relatively low nutrient concentrations. This means that more technologically advanced and reliable treatment options, for example, bioreactors, are prohibitively expensive. However, some systems, such as use of recirculation systems typically increase nutrient concentrations, and hence the efficiency and effectiveness of more expensive treatment methods. Biofloc systems can also provide a mechanism for in‐situ nutrient treatment as well as a supplementary food source for animals. Overall, there is scope to improve treatment of waste nutrients, but significant modifications to many production systems are needed to achieve this.
Vacterl syndrome: Medical and stomatological considerations for comprehensive patient management
Authors: Do Amaral Cristhiane Olívia Ferreira , Souza Ana Flávia Ferreira Barros De , Carlucci Guilherme Peratelli , Lima Leticia Da Silva , Amaral Mariana Olívia Ferreira Do , Straioto Fabiana Gouveia 
Published: May 2024

AbstractAimThe VACTERL association or Syndrome consists of Vertebral, Anorectal, Cardiac, Tracheo–Esophageal, Renal, and Limb defects. The diagnosis relies on the presence of at least three of these structural abnormalities. This study reports a single case of a patient with VACTERL Syndrome (VS), aiming to assist dentists in recognizing the general aspects, systemic changes, and oral care related to this condition.Case reportA 14‐year‐old female patient medically diagnosed with VS. The study evaluated the presence of systemic alterations, medication use, behavioral deviations, cognitive development, and oral aspects. The patient exhibited cardiovascular alterations including a ventricular septal defect (C), anal atresia (A), polydactyly (considered limb alteration—L), and scoliosis (a possible indication of vertebral anomalies—V). In the intraoral examination, findings included tooth crowding, enamel hypomineralization in several teeth, a deep and atretic palate, generalized gingivitis, bleeding, gingival hyperplasia, Class III malocclusion, and a right unilateral crossbite.ConclusionPatients diagnosed with VACTERL syndrome experience significant systemic impairments. The research subject presented compromised oral health, challenges in dental management, delays in neuropsychomotor development, though these are not inherent to the syndrome. It is crucial to prevent oral diseases and provide early dental care for these patients to avoid the need for complex and invasive dental treatments due to systemic impairments.
Turning green through within‐firm adjustment: Evidence from environmental court in China
Authors: Gao Xiang , Tian Suhua , Wang Huanhuan , Wang Xuan 
Published: May 2024

AbstractThis paper investigates how the setup of special environmental courts is accountable for firms' internal adjustment of production and export across industries with different pollution intensities. Inspired by a simple theoretical model, we find that, after the establishment of environmental courts, firms see a larger decrease in export value, export quantity, export variety as well as export destination in more polluting industries. We further find different impacts on firms with varying ownership and size. These findings imply that companies reallocate their available resources from more polluting varieties to less polluting ones, thus turning green through this within‐firm adjustment.
Outcome of video‐assisted thoracoscopic treatment of idiopathic chylothorax in 15 cats
Authors: Dickson Rachel , Adam Antoine , Garcia Rubio David , Cinti Filippo , Singh Ameet , Mayhew Philipp , Case J. Brad , Fransson Boel A. 
Published: May 2024

AbstractObjectiveTo evaluate the outcomes and complications of video‐assisted thoracoscopic (VATS) treatment of chylothorax in cats.Study designMulti‐institutional retrospective study.AnimalsFifteen client‐owned cats.MethodsThe medical records of cats undergoing thoracoscopic thoracic duct ligation (TDL) for treatment of idiopathic chylothorax were reviewed. Cats undergoing additional procedures including thoracoscopic pericardectomy and/or laparoscopic cisterna chyli ablation (CCA)_were included. Follow up was obtained through communication with the referring veterinarian or owner.ResultsAll cats underwent thoracoscopic TDL. Thirteen cats underwent simultaneous pericardectomy and two cats underwent laparoscopic CCA without pericardectomy. Conversion from a thoracoscopic to open approach was necessary in 2/15 (13%) of thoracic duct ligations and 1/11 (9%) of pericardectomies. The most common postoperative complication was persistent pleural effusion in five cats (33%). Four of 15 cats (27%) died or were euthanized prior to hospital discharge following surgery. Recurrence of effusion occurred in 1/7 (14%) of cats that sustained resolution of the effusion at the time of surgery with a median follow up of 8 months. The overall mortality attributed to chylothorax was 47%.ConclusionThoracoscopic treatment of idiopathic chylothorax resulted in a low incidence of intraoperative complications or conversion in the study population; however, mortality related to feline idiopathic chylothorax remained high.Clinical significanceWhile VATS treatment of idiopathic chylothorax is technically feasible, further consideration of the underlying pathology and current treatment algorithm is needed to improve outcomes as this remains a frustrating disease to treat in the feline population.
Water Transfer Energy Efficiency Index for inter‐basin water transfer projects
Authors: Yi Sooyeon 
Published: May 2024

AbstractInter‐basin water transfer projects (WTPs) address water scarcity by lifting water uphill, posing energy challenges due to diverse topography. This study therefore analyses historical trends in WTP distance, average annual water volumes delivered, water lift and pumping capacity to develop the Water Transfer Energy Efficiency Index (WTEEI) and apply it for the assessment of WTPs. Results indicate that the WTEEI is a valuable tool for evaluating WTP energy efficiency. While no definitive trend in WTEEI values was observed, the findings suggest the need for monitoring of energy use of WTPs and more research to better understand and improve the energy efficiency of these large‐scale infrastructure projects. By introducing a simple, intuitive and rapid assessment tool for evaluating energy efficiency in WTPs, this study addresses a critical gap in the water–energy field, namely, the evaluation of energy usage in WTPs and the identification of energy‐efficiency improvements for current and future WTPs.