bluuebunny/crossref_metadata_2025_split huggingface dataset:
Closed FRW holography: a time-dependent ER=EPR realization
Authors: Franken Victor , Partouche Hervé , Rondeau François , Toumbas Nicolaos 
Published: May 2024

Abstract
We extend a recent de Sitter holographic proposal and entanglement entropy prescription to generic closed FRW cosmologies in arbitrary dimensions, and propose that for large classes of bouncing and Big Bang/Big Crunch cosmologies, the full spacetime can be encoded holographically on two holographic screens, associated to two antipodal observers. In the expanding phase, the two screens lie at the apparent horizons. In the contracting phase, there is an infinite number of possible trajectories of the holographic screens, which can be grouped in equivalence classes. In each class the effective holographic theory can be derived from a pair of “parent” screens on the apparent horizons. A number of cases including moduli dominated cosmologies escape our discussion, and it is expected that two antipodal observers and their associated screens do not suffice to reconstruct these cosmologies. The leading contributions to the entanglement entropy between the screens arise from a minimal extremal trapped or anti-trapped surface lying in the region between them. This picture entails a time-dependent realization of the ER=EPR conjecture, where an effective geometrical bridge connecting the screens via the minimal extremal surface emerges from entanglement. For the Big Crunch contracting cases, the screens disentangle and the geometrical bridge closes off when the minimal extremal trapped sphere hits the Big Crunch singularity at a finite time before the collapse of the Universe. Semiclassical, thermal corrections are incorporated in the cases of radiation dominated cosmologies.
Di-electron production at the LHC: unravelling virtual-photon and heavy-flavour contributions
Authors: Andronic Anton , Ježo Tomáš , Klasen Michael , Klein-Bösing Christian , Neuwirth Alexander Puck 
Published: May 2024

Abstract
The production of virtual photons is a very sensitive probe of the properties of the quark-gluon plasma. As they are experimentally detected by lepton pairs, they suffer from a large background arising from hadron decays. Light-flavour hadrons dominate at low invariant masses below mee ~ 0.5 GeV and heavy flavours above. These contributions must therefore also be taken into account in experimental analyses at the LHC. In this paper, we calculate the direct contribution from virtual photons produced in the Drell-Yan process with an additional jet in POWHEG and find that it is significant at low invariant masses. We also simulate the background contributions from $$ c\overline{c} $$
c

c
¯

and $$ b\overline{b} $$
b

b
¯

production with POWHEG and quantify the theoretical uncertainties due to variations of the perturbative scales and parton distribution functions. We find larger relative and absolute uncertainties for the lighter c quarks than for heavier b quarks.
νe → νe scattering with massive Dirac or Majorana neutrinos and general interactions
Authors: Márquez Juan Manuel , Roig Pablo , Salinas Mónica 
Published: May 2024

Abstract
We calculate the neutrino-electron elastic scattering cross section, extending the results previously obtained in ref. [1], in the presence of generic new interactions that take into account all the effects caused by finite neutrino masses. We address the potential significance of a heavy neutrino sector during precision measurements, particularly for tau neutrinos scattering with masses in the MeV range, for which the existing upper bounds on |Uτ4|2 would result in conceivably measurable contributions. Finally, we comment on the possibility to distinguish between Dirac and Majorana neutrinos, including the analysis of the new emerging parameters and its application to illustrative model-dependent scenarios.
Variations of the Mutual Curvature of Two Orthogonal Non-complementary Distributions
Authors: Rovenski Vladimir , Zawadzki Tomasz 
Published: May 2024

AbstractOn a smooth manifold with distributions $$\mathcal {D}_1$$

D
1

and $$\mathcal {D}_2$$

D
2

having trivial intersection, we consider the integral of their mutual curvature, as a functional of Riemannian metrics that make the distributions orthogonal. The mutual curvature is defined as the sum of sectional curvatures of planes spanned by all pairs of vectors from an orthonormal basis, such that one vector of the pair belongs to $$\mathcal {D}_1$$

D
1

and the second vector belongs to $$\mathcal {D}_2$$

D
2

. As such, it interpolates between the sectional curvature of a plane field (if both distributions are one-dimensional), and the mixed scalar curvature of a Riemannian almost product structure (if both distributions together span the tangent bundle). We derive Euler–Lagrange equations for the functional, formulated in terms of extrinsic geometry of distributions, i.e., their second fundamental forms and integrability tensors. We give examples of critical metrics for distributions defined on domains of Riemannian submersions, twisted products and f–K-contact manifolds.
Borsik’s Properties of Topological Spaces and Their Applications
Authors: Natkaniec Tomasz 
Published: May 2024

AbstractLet X be an uncountable Polish space. L̆ubica Holá showed recently that there are $$2^{\mathfrak {c}}$$

2
c

quasi-continuous real valued functions defined on the uncountable Polish space X that are not Borel measurable. Inspired by Holá’s result, we are extending it in two directions. First, we prove that if X is an uncountable Polish space and Y is any Hausdorff space with $$|Y|\ge 2$$

|
Y
|
≥
2

then the family of all non-Borel measurable quasi-continuous functions has cardinality $$\ge 2^{{\mathfrak {c}}}$$

≥

2
c

. Secondly, we show that the family of quasi-continuous non Borel functions from X to Y may contain big algebraic structures.
The emergence of sulfo-click amidation in kinetic target-guided synthesis
Authors: Parvatkar Prakash T. , Manetsch Roman 
Published: May 2024

AbstractSulfo-click is a chemoselective and biocompatible reaction between thioacids and sulfonyl azides that forms highly versatile N-acylsulfonamides, interesting bioisosteres of carboxylic acids. This reaction is useful for chemists and biologists and has many applications in medicinal chemistry, drug discovery, bioconjugation chemistry, and chemical biology. Sulfo-click amidations have been extensively used in kinetic target-guided synthesis (KTGS) to identify modulators of protein-protein interactions (PPIs). Different variants of KTGS screening, such as binary and multi-fragments, as well as one-pot deprotection/amidation strategies, have been successfully performed using sulfo-click chemistry. In this mini-review, we discuss the recent developments of sulfo-click amidation in KTGS and provide directions for future research.
Chronische Rhinosinusitis mit nasalen Polypen – Verlängerung der Dupilumab-Therapieintervalle
Authors: Appel H. M. , Lochbaum R. , Hoffmann T. K. , Hahn J. 
Published: May 2024

Zusammenfassung
Hintergrund
Eine schwere, nicht kontrollierte chronische Rhinosinusitis mit nasalen Polypen (CRSwNP) kann sich unter Dupilumab 300 mg 2‑wöchentlich komplett zurückbilden. Spätestens dann folgt die Frage der Patienten nach einer möglichen Therapiedeeskalation. Eine Beendigung der Antikörpertherapie nach 24 Wochen führte zum Rezidiv, hingegen blieb unter reduzierter Dupilumab-Dosis durch Streckung des Intervalls auf 4 Wochen die Kontrolle erhalten. Eine vom Zulassungstext abweichende Verlängerung der Therapieintervalle wird jedoch aktuell nicht empfohlen.

Methoden
Es erfolgte eine retrospektive Untersuchung des Verlaufs von 29 Patienten mit schwerer CRSwNP, mit Typ-2-Inflammation assoziierten Komorbiditäten und bestehender Indikation zur Biologikatherapie. Nach Rückbildung der CRSwNP und der Beschwerden unter Dupilumab 300 mg 2‑wöchentlich war das Applikationsintervall individuell zunächst auf 4 Wochen, danach ggf. auf 6 Wochen verlängert worden. Erfasst wurden u. a. die Lebensqualität (Sinonasal Outcome Test, SNOT-22), der nasale Polypenscore (NPS) und das Riechvermögen (Sniffinʼ Sticks, Fa. Burghart Messtechnik, Holm, Deutschland).

Ergebnisse
Alle Patienten zeigten innerhalb der ersten 3 Monate ein sehr gutes Therapieansprechen. Eine Verlängerung des Dupilumab-Intervalls auf 4 Wochen erfolgte nach 7–31 Monaten (median 13 Monate), auf 6 Wochen (n = 9) nach 17–35 Monaten (median 23 Monate). Im Verlauf traten bei keinem Patienten ein Rezidiv, eine Verschlechterung der Lebensqualität oder des Riechens auf.

Schlussfolgerung
Eine Verlängerung der Dupilumab-Injektionsintervalle auf 4 evtl. auch 6 Wochen ist individuell nach weitestgehender Rückbildung der Polypen und Beschwerden ohne klinische Verschlechterung möglich. Weitere Studien zur Deeskalation bzw. Beendigung der Biologikatherapie bei erzielter CRSwNP-Kontrolle sind unabdingbar.
Low frequency of the wild-type freezing-tolerance LsCBF7 allele among lettuce population suggests a negative selection during domestication and breeding
Authors: Park Sunchung , Shi Ainong , Mou Beiquan 
Published: May 2024

Abstract
Key message
Sustainable winter production in lettuce requires freezing tolerant varieties. This study identified a wild-type allele of LsCBF7 that could contribute to freezing tolerance improvement in lettuce.

Abstract
Lettuce is one of the most consumed vegetables globally. While ideally grown in 13–21 °C, its cultivation extends into winter in milder climates. However, occasional freezing temperatures can significantly reduce yields. Therefore, the development of freezing-tolerant lettuce varieties has become a long-term goal of lettuce breeding programs. Despite its significance, our understanding of freezing tolerance in lettuce remains limited. Plants have evolved a coping mechanism against freezing, known as cold acclimation, whereby they can increase freezing tolerance when pre-exposed to low nonfreezing temperatures. The CBF pathway is well-known for its central role in cold acclimation. Previously, we identified 14 CBF genes in lettuce and discovered that one of them, LsCBF7, had a loss-of-function mutation. In this study, we uncovered that accessions from colder regions carried the wild-type allele of LsCBF7 and this allele likely contributed to increased freezing tolerance, with 14% of the lettuce population carrying this allele. Interestingly, in wild lettuce (L. serriola) that is considered a progenitor of cultivated lettuce, this wild-type allele was much more common, with a frequency of 90%. This finding suggests that this wild-type allele may have undergone negative selection during the domestication or breeding of lettuce. Our data strongly indicate that this allele could be linked to early bolting, an undesirable trait in lettuce, which may have driven the negative selection. While this wild-type allele shows promise for improving freezing tolerance in lettuce, it is crucial to decouple it from the early bolting trait to fully harness its potential in lettuce breeding.
Bone metabolism in diabetes: a clinician’s guide to understanding the bone–glucose interplay
Authors: Sheu Angela , White Christopher P. , Center Jacqueline R. 
Published: May 2024

AbstractSkeletal fragility is an increasingly recognised, but poorly understood, complication of both type 1 and type 2 diabetes. Fracture risk varies according to skeletal site and diabetes-related characteristics. Post-fracture outcomes, including mortality risk, are worse in those with diabetes, placing these people at significant risk. Each fracture therefore represents a sentinel event that warrants targeted management. However, diabetes is a very heterogeneous condition with complex interactions between multiple co-existing, and highly correlated, factors that preclude a clear assessment of the independent clinical markers and pathophysiological drivers for diabetic osteopathy. Additionally, fracture risk calculators and routinely used clinical bone measurements generally underestimate fracture risk in people with diabetes. In the absence of dedicated prospective studies including detailed bone and metabolic characteristics, optimal management centres around selecting treatments that minimise skeletal and metabolic harm. This review summarises the clinical landscape of diabetic osteopathy and outlines the interplay between metabolic and skeletal health. The underlying pathophysiology of skeletal fragility in diabetes and a rationale for considering a diabetes-based paradigm in assessing and managing diabetic bone disease will be discussed.
Graphical Abstract
Role of buttering layer composition on microstructural heterogeneity and mechanical properties of Alloy 617 and P92 steel dissimilar welded joints for future Indian AUSC program
Authors: Rathore Saurabh , Kumar Amit , Sirohi Sachin , Singh Vivek , Gupta Ankur , Fydrych Dariusz , Pandey Chandan 
Published: May 2024

AbstractRestrictive operating conditions (even exceeding 700 °C) of materials in advanced ultra super critical (AUSC) power plants and the need to minimize manufacturing and maintenance costs require the production of dissimilar metal welded joints (DMW). Significant differences in the physical and chemical properties of welded materials lead to phenomena that reduce the weldability of the metals used and force the search for solutions that limit unfavorable phenomena, e.g., the use of buttering layers. The study presents a comparison of two types of joints with Alloy 617 (UNS N06617) and ferritic P92 (UNS K92460) steel made using Inconel 82 (ENiCrFe-3) and Inconel 617 (ERNiCrCoMo-1) alloys buttering layer and the corresponding chemical composition of filler metals. All areas of the joints made with the gas tungsten arc welding process were subjected to structural investigations (optical microscopy, scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDS) and mechanical tests (microhardness, room and high temperature tensile, and toughness testing). Despite the more complicated welding procedure, sound welded joints were obtained with favorable properties resulting, inter alia, from the reduced thickness of the martensite layer in HAZ of P92 steel and the limited diffusion of alloy components compared to welded joints without the buttering layer. This also resulted in a reduction of the maximum hardness (especially in the case of Inconel 82 buttering—by 15–30 HV0.5 in comparison with Inconel 617 buttering) and an increase in strength while limiting the decrease in plasticity (even 663 MPa tensile strength and 21% of elongation for Inconel 617 buttered joint). Moreover, improved high-temperature performance (approximately 70–100 MPa) of the welded joint following the application of the buttering layer was confirmed. The presented results allow for drawing general conclusions that both proposed welding procedures can be recommended for use in the working conditions occurring at AUSC.
Design, motion-planning, and manufacturing of custom-shaped tools for five-axis super abrasive machining of a turbomachinery blade type component
Authors: Martinez-Aguirre Maialen , Gómez Gaizka , Bo Pengbo , Barton Michael , González-Barrio Haizea , Calleja-Ochoa Amaia , de Lacalle Luis Norberto López 
Published: May 2024

AbstractFree-form surfaces generated by non-uniform rational B-splines (NURBS) are evolving to face turbomachinery component requirements, such as turbine blades to enhanced efficiency. Super abrasive machining (SAM) is presented as a potential process for high-added value components using custom-shaped tools to be adapted to any surface. The adaptability and flexibility of these tool concepts are specifically designed to fit these complex surfaces. This paper presents an innovative manufacturing approach for blade type components using a custom-shaped tool designed through an optimization process that simultaneously optimizes both the shape of the tool and its motion. The proposed method with SAM finishing using a custom-shaped tool is compared against a standard tool and traditional machining process. The result obtained on the blade test case shows that the custom-shaped tools need fewer paths, yet produce more accurate surface finish.
Novel Uses of the SwiftNinja Steerable Microcatheter for Pediatric Cardiovascular Interventions
Authors: Herron Christopher , Shahanavaz Shabana 
Published: May 2024

Abstract
In the present era, the intricacy of procedures undertaken by a pediatric interventional cardiologist has increased, primarily attributed to dealing with smaller, younger patients with more complex anatomies. To adapt to these smaller and more complex patients, we must adapt our interventions and our equipment to perform these procedures. This article outlines various innovative applications of the SwiftNinja steerable microcatheter within the pediatric cardiac catheterization laboratory.
Coaggregated E. faecalis with F. nucleatum regulated environmental stress responses and inflammatory effects
Authors: Zhou Jiani , Yuan Zijian , Yang Ruiqi , Liu Tingjun , Lu Xianjun , Huang Wenling , Guo Lihong 
Published: May 2024

Abstract
To investigate the cell-cell interactions of intergeneric bacterial species, the study detected the survival of Enterococcus faecalis (Ef) under monospecies or coaggregation state with Fusobacterium nucleatum subsp. polymorphum (Fnp) in environmental stress. Ef and Fnp infected the human macrophages with different forms (Ef and Fnp monospecies, Ef-Fnp coaggregates, Ef + Fnp cocultures) for exploring the immunoregulatory effects and the relevant molecular mechanisms. Meanwhile, the transcriptomic profiles of coaggregated Ef and Fnp were analyzed. Ef was shown to coaggregate with Fnp strongly in CAB within 90 min by forming multiplexes clumps. Coaggregation with Fnp reinforced Ef resistance against unfavorable conditions including alkaline, hypertonic, nutrient-starvation, and antibiotic challenges. Compared with monospecies and coculture species, the coaggregation of Ef and Fnp significantly facilitates both species to invade dTHP-1 cells and aid Ef to survive within the cells. Compared with coculture species, dual-species interaction of Ef and Fnp significantly decreased the levels of pro-inflammatory cytokines IL-6, TNF-α, and chemokines MCP-1 secreted by dTHP-1 cells and lessened the phosphorylation of p38, JNK, and p65 signaling pathways. The transcriptome sequencing results showed that 111 genes were differentially expressed or Ef-Fnp coaggregated species compared to Ef monospecies; 651 genes were differentially expressed for Fnp when coaggregation with Ef. The analysis of KEGG pathway showed that Ef differentially expressed genes (DEGs) were enriched in quorum sensing and arginine biosynthesis pathway; Fnp DEGs were differentially concentrated in lipopolysaccharide (LPS) biosynthesis, biofilm formation, and lysine degradation pathway compared to monospecies.

Key points
• Coaggregated with Fnp aids Ef’s survival in environmental stress, especially in root canals after endodontic treatment.
• The coaggregation of Ef and Fnp may weaken the pro-inflammatory response and facilitate Ef to evade killed by macrophages.
• The coaggregation between Ef and Fnp altered interspecies transcriptional profiles.
TP-PROFILE: Monitoring the Thermodynamic Structure of the Troposphere over the Third Pole
Authors: Chen Xuelong , Liu Yajing , Ma Yaoming , Ma Weiqiang , Xu Xiangde , Cheng Xinghong , Li Luhan , Xu Xin , Wang Binbin 
Published: May 2024

AbstractGround-based microwave radiometers (MWRs) operating in the K- and V-bands (20–60 GHz) can help us obtain temperature and humidity profiles in the troposphere. Aside from some soundings from local meteorological observatories, the tropospheric atmosphere over the Tibetan Plateau (TP) has never been continuously observed. As part of the Chinese Second Tibetan Plateau Scientific Expedition and Research Program (STEP), the Tibetan Plateau Atmospheric Profile (TP-PROFILE) project aims to construct a comprehensive MWR troposphere observation network to study the synoptic processes and environmental changes on the TP. This initiative has collected three years of data from the MWR network. This paper introduces the data information, the data quality, and data downloading. Some applications of the data obtained from these MWRs were also demonstrated. Our comparisons of MWR against the nearest radiosonde observation demonstrate that the TP-PROFILE MWR system is adequate for monitoring the thermal and moisture variability of the troposphere over the TP. The continuous temperature and moisture profiles derived from the MWR data provide a unique perspective on the evolution of the thermodynamic structure associated with the heating of the TP. The TP-PROFILE project reveals that the low-temporal resolution instruments are prone to large uncertainties in their vapor estimation in the mountain valleys on the TP.
The effect of a collar on primary stability of standard and undersized cementless hip stems: a biomechanical study
Authors: Kistler Manuel , Steinbrück Arnd , Schmidutz Florian , Paulus Alexander C. , Holzapfel Boris Michael , Woiczinski Matthias 
Published: May 2024

Abstract
Introduction
Aseptic loosening and periprosthetic fractures are main reasons for revision after THA. Quite different from most other stem systems, Corail cementless hip stems show better survival rates than their cemented counterpart, which can possibly be explained by the use of a collar. The study aimed to investigate primary stability with standard and undersized hip stems both collared and collarless.

Materials and methods
Primary stability of cementless, collared and collarless, femoral stems was measured in artificial bones using both undersized and standard size. After preconditioning, 3D micromotion was measured under cyclic loading at the bone-implant interface.

Results
The use of a collar resulted in higher micromotion within the same stem size but showed no statistically significant difference for both standard and undersized hip stems. The collared and collarless undersized stems showed no significant differences in 3D micromotion at the upper measuring positions compared to the standard stem size. Micromotion was significantly higher in the distal measuring positions, with and without collar, for the undersized stems (vs. standard collarless stem size).

Conclusion
The key finding is that the collarless and collared Corail hip stems, within one stem size, showed no significant differences in primary stability. Undersized stems showed significantly higher micromotion in the distal area both with and without collar.