bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychologie des rêves et plaisir d’écriture
Authors: Carroy Jacqueline 
Published: May 2024

Dans ces extraits sont transcrits des récits de ses rêves manuscrits inédits déposés à la Bibliothèque de Genève par le physicien et psychologue genevois Pierre Prévost entre 1803 et 1834. Ces « songes et exemples » semblent avoir été conservés pour leur caractère savoureux et énigmatique. Se mélangent, dans cette collection, exemples humoristiques et savants, tandis que l’actualité brûlante y apparaît en sourdine. La psychologie de Prévost s’est nourrie d’un plaisir d’écriture, puis de relecture. Elle renvoie peut-être à un « Ancien Régime » des songes, où l’on pouvait souvent, plus que maintenant, s’amuser des visions et des voix de ses nuits.
Replication Stress in Activated Human NK Cells Induces Sensitivity to Apoptosis
Authors: Guilz Nicole C , Ahn Yong-Oon , Fatima Hijab , Pedroza Luis Alberto , Seo Seungmae , Soni Rajesh Kumar , Wang Ning , Egli Dieter , Mace Emily M 
Published: May 2024

Abstract
NK cells are innate immune effectors that kill virally infected or malignant cells. NK cell deficiency (NKD) occurs when NK cell development or function is impaired and variants in MCM4, GINS1, MCM10, and GINS4 result in NKD. Although NK cells are strongly impacted by mutational deficiencies in helicase proteins, the mechanisms underlying this specific susceptibility are poorly understood. In this study, we induced replication stress in activated NK cells or T cells by chemical and genetic methods. We found that the CD56bright subset of NK cells accumulates more DNA damage and replication stress during activation than do CD56dim NK cells or T cells. Aphidicolin treatment increases apoptosis of CD56bright NK cells through increased pan-caspase expression and decreases perforin expression in surviving cells. These findings show that sensitivity to replication stress affects NK cell survival and function and contributes to NKD.
Functional Heterogeneity of Umbilical Cord Blood Monocyte-Derived Dendritic Cells
Authors: Schweiger Petra , Hamann Livia , Strobel Julian , Weisbach Volker , Wandersee Alexandra , Christ Julia , Kehl Sven , Weidenthaler Filip , Antoniadis Sophia , Hackstein Holger , Cunningham Sarah 
Published: May 2024

Abstract
Human umbilical cord blood (UCB) represents a unique resource for hematopoietic stem cell transplantation for children and patients lacking suitable donors. UCB harbors a diverse set of leukocytes such as professional APCs, including monocytes, that could act as a novel source for cellular therapies. However, the immunological properties of UCB monocytes and monocyte-derived dendritic cells (MoDCs) are not fully characterized. In this study, we characterized the phenotype and functions of UCB-MoDCs to gauge their potential for future applications. UCB exhibited higher frequencies of platelets and lymphocytes as well as lower frequencies of neutrophils in comparison with adult whole blood. Leukocyte subset evaluation revealed significantly lower frequencies of granulocytes, NK cells, and CD14+CD16− monocytes. Surface marker evaluation revealed significantly lower rates of costimulatory molecules CD80 and CD83 while chemokine receptors CCR7 and CXCR4, as well as markers for Ag presentation, were similarly expressed. UCB-MoDCs were sensitive to TLR1–9 stimulation and presented quantitative differences in the release of proinflammatory cytokines. UCB-MoDCs presented functional CCR7-, CXCR4-, and CCR5-associated migratory behavior as well as adequate receptor- and micropinocytosis-mediated Ag uptake. When cocultured with allogeneic T lymphocytes, UCB-MoDCs induced weak CD4+ T lymphocyte proliferation, CD71 expression, and release of IFN-γ and IL-2. Taken together, UCB-MoDCs present potentially advantageous properties for future medical applications.
Mechanical ventilation and outcomes in COVID-19 patients admitted to intensive care unit in a low-resources setting: A retrospective study
Authors: Assenouwe Sarakawabalo , Mouzou Tabana Essohanam , Ahounou Ernest , Bawe Lidaw Déassoua , Kotosso Awèréou , Aziagbe Koffi Atsu , Amekoudi Eyram Makafui Yoan , Omourou Mamoudou , Anoudem Chimene Etonga , Adjoh Komi Séraphin 
Published: May 2024

Objective:
To describe the strategies and outcomes of mechanical ventilation in a poorly equipped facility.

Methods:
This retrospective descriptive study included patients with COVID-19 who were admitted to the intensive care unit (ICU) and mechanically ventilated between September 1, 2020, and May 31, 2021. Data were collected from medical records and databases.

Results:
54 Patients aged (62.9±13.3) years were included. Among these cases, 79.6% had at least one comorbidity. On admission, all patients had hypoxia. The median peripheral oxygen saturation in room air was 76% (61%, 83%). Non-invasive ventilation (NIV) was performed in 75.9% of the patients, and invasive mechanical ventilation (IMV) in 68.5%. IMV was performed on patients due to severe coma (8.1%), failure of standard oxygen therapy (27.0%), and failure of NIV (64.9%). An arterial blood gas test was performed in 14.8% of the patients. NIV failed in 90.2% of cases and succeeded in 9.8%. IMV was successful in 5.4% of cases, vs. 94.6% of mortality. The overall mortality rate of patients on ventilation in the ICU was 88.9%. The causes of death included severe respiratory distress syndrome (85.2%), multiple organ failure (14.8%), and pulmonary embolism (13.0%).

Conclusions:
The ventilation management of COVID-19 patients in the ICU with NIV and IMV in a scarce resource setting is associated with a high mortality rate. Shortcomings are identified in ventilation strategies, protocols, and monitoring. Required improvements were also proposed.
Infantile Systemic Hyalinosis
Authors: Al Kaissi Ali , Hilmi Marwa , Betadolova Zulfiya , Bouchoucha Sami , Trofimova Svetlana , Shboul Mohammad , Rustamov Guseyn , Dwera Wiam , Sigl Katharina , Kenis Vladimir , Kircher Susanne Gerit 
Published: May 2024

Background:
Infantile systemic hyalinosis (ISH) is an autosomal recessively inherited disorder. The classical natural history of the disease is characterised by hypotonia, multiple contractures, skin lesions, osteopenia, joint pain, bone fractures, persistent diarrhoea and growth deficiency.

Materials and Methods:
Two children manifested the severe type of ISH underwent genotypic confirmation. In order to identify which other family members have inherited the disease. We included siblings and cousins in this study. The baseline tool to study other family subjects was based on the phenotypic characterisations of each child.

Results:
Two children with the severe type of ISH showed craniosynostosis (brachycephaly and scaphocephaly) associated with multiple contractures, progressive joint osteolysis ending up with multiple joint dislocations. The full exome sequencing was carried out, revealing a previously reported heterozygous nonsense mutation с.1294С>Т and a novel heterozygous non-synonymous substitution c. 58T>A in ANTRX2 gene. Three children (sibling and cousins) manifested variable clinical manifestations relevant to ISH. Specifically, asymptoamtic skin and skeletal abnormalities of hypoplastic clavicles and 'shepherd's crook' deformity and coxa vara.

Conclusion:
It is mandatory to perform extensive family pedigree search to detect asymptomatic clinical features in siblings and cousins in families with first degree related marriages. Interestingly, in the mild and the moderate types of ISH, we observed undescribed combination of asymptomatic skin and skeletal abnormalities. This is a comparative study between the severe and the mild/moderate types in a group of children from consanguineous families. Our current study extends the phenotypic characterisations of ISH.
Efficacy of Fluocinonide\Bifonazole Cream for the Treatment of Trachyonychia
Authors: Shemer Avner , Daniel Ralph , Kassem Riad , Sharon Nechama , Farhi Renata , Kaplan Baruch , Hermush Vered , Galili Eran 
Published: May 2024

Background:
Trachyonychia is a benign nail condition, most commonly seen in children. Trachyonychia manifests as excessive longitudinal ridging, nail roughness, and nail brittleness. Treatment is sought mainly for esthetic reasons as well as functional reasons. A number of therapeutic approaches exist, mainly based on case reports or small non-comparative case series.

Aims:
To report treatment outcome among patients with trachyonychia.

Methods:
A retrospective case-series study was conducted among patients who were treated trachyonychia between years 2017 and 2020. Patients were prescribed fluocinonide 0.05% with bifonazole 1% cream, applied with or without occlusion, and methylprednisolone 1–2 mg/nail, injected into the involved nail matrix, or oral cyclosporine 3 mg/kg. Complete response (over 90% improvement) and partial response (over 50% improvement) were assessed.

Results:
A total of 43 patients with trachyonychia were included [mean age 10.0 years (±5.7), 69.8% males, mean disease duration 4.7 years (±3.0)]. In 90.7% of the cases, topical fluocinonide\bifonazole cream was prescribed. Under-occlusion topical application was found to be highly effective, achieving complete response in 35.3% and partial response in an additional 52.9% of the patients. Occluded application was also found to be significantly more effective than non-occluded application. Treatment efficacy was not affected by the severity of nail roughness, trachyonychia morphology, or whether trachyonychia was idiopathic or coexisted with other dermatological conditions.

Conclusion:
Occluded application of fluocinonide plus bifonazole cream is efficient for the treatment of trachyonychia and should be considered a first line of treatment.
Evaluation of Dermoscopic Patterns of Vesiculobullous Disorders
Authors: Narkhede Namita D. , Nikham Balakrishna , Jamale Varsha , Hussain Asma , Kale Mohan 
Published: May 2024

Background:
Clinical diagnosis of vesiculobullous disorders (VBD) is not always straightforward. It is a challenge for a dermatologist to make the right diagnosis noninvasively in a short time.

Objective:
To evaluate dermoscopic patterns associated with vesiculobullous disorders.

Methods:
A total of 230 patients, irrespective of age and gender, with a history and clinical presentation suggestive of VBD (including primarily infectious, inflammatory, genetic, antibody-mediated, mechanical, environmental, metabolic, and drug-related) were recruited into the study. Patients with secondarily infected lesions were excluded. Dermoscopic examination along with Tzanck smear/skin biopsy smear test was performed on the most representative lesions. Data were compiled and statistically analyzed using SPSS version 21.0.

Results:
Lesions with erythematous (vascular) and yellowish (serum) translucent background with regular margins were seen in most of the VBD studied. Chickenpox (CP) and herpes zoster (HZ) lesions evolved with the progress of their clinical stages. Follicular and eccrine openings were commonly seen, but the pigmentation around them was specific to pemphigus vulgaris. A distorted pigment network was noted in bullous pemphigoid. White rosettes (keratin blockage) were characteristic of epidermolysis bullosa, Wickham striae (orthokeratosis) of lichen planus, and crumpled fabric appearance (flaccidity) of Hailey-Hailey disease. Globules/dots (microvesicles) of different colors were also seen in various VBD. Blue/black color usually corresponded to retained melanin.

Conclusion:
Some dermoscopic patterns are observed consistently with certain diseases, and these can be used for their diagnosis, complementary to histopathological examination.
Fragrance, Sunscreens, Botanicals, and Potential Allergens in Bestseller 'Fairness' Creams in the Indian Market
Authors: Gopinath Hima , Manjula Bodicharla , Karthikeyan Kaliaperumal 
Published: May 2024

Background:
The skin lightening industry has seen exponential growth in India. Consumers often present to the dermatologist with adverse cutaneous reactions to these 'fairness' (skin lightening) creams. The composition of these creams has not received sufficient attention.

Objective:
To identify fragrance, sunscreens, botanicals and potential allergens in the bestseller 'fairness' creams available in the Indian market.

Methods:
Twenty fairness (or whitening or lightening) creams were selected based on the 'bestseller' creams of one of the largest electronic commerce websites in India, and availability in local stores and unlabelled brands were excluded. Fragrance, sunscreens, botanicals and potential allergens were identified from the ingredient labels.

Results:
Twenty bestseller fairness creams were included. The number of the listed ingredients in the fairness creams ranged from 6 to 49 (mean = 32.2). The most frequently listed ingredients included water, fragrance or parfum, glycerin, tocopherol/tocopherylacetate and titanium dioxide. Hydroquinone, monobenzyl hydroquinone, corticosteroids, tretinoin and mercury were not listed in any of the creams. Unspecified fragrance was listed in 19 (95%) creams and linalool (8,40%) was the most frequent specified fragrance. Titanium dioxide (14, 70 %) was the most common inorganic sunscreen and ethylhexyl methoxycinnamate (12 creams or 60% of creams) was the most common organic sunscreen. Twenty-seven botanicals were identified. Eight ingredients were potential allergens according to the Indian Cosmetic and Fragrance Series. The cost of the creams ranged from 95 to 1,095 in Indian rupees (mean 300.5).

Conclusions:
Consumers are exposed to a vast range of compounds in the quest for a lighter skin tone. Several potential allergens, particularly fragrance allergens, are present in addition to the eight allergens that were identified with the Indian Cosmetic and Fragrance Series. Increased awareness of the composition of skin lightening creams available in the market and strict regulation of these creams is needed.
Reliability of Two Newly Designed Pelvic Inclinometer for Measurement of Pelvic Inclination in Sagittal Plane
Authors: Bali Nishant Kumar , Raghav Deepak , Dwivedi Amit 
Published: May 2024

Context:
The use of a pelvic inclinometer in medical practice to evaluate pelvic inclination angle is speedy, noninvasive, and easy to use. There is currently no goniometer available for objective measurement of innominate bone inclination in standing. In clinical assessment, it is necessary to employ portable, reliable, low-cost, and safe measurement apparatus for the measurement of pelvic inclination.

Aims:
To assess the inter- and intra-tester reliability of a tripod-mounted pelvic inclinometer and a hand-held inclinometer with smartphone application for measuring the angle of pelvic inclination in the sagittal plane.

Study Setting and Design:
Design of assessing and measuring reliability of pelvic inclinometer in India.

Materials and Methods:
A total of 160 individuals aged between 18 and 30 years volunteered to participate in the study. Pelvic inclination angle was measured on both sides using two newly developed pelvic inclinometers in the sagittal plane. One was tripod-mounted wooden arm inclinometer and the other was hand-held inclinometer with smartphone software application. Reliability was assessed for the tripod-mounted pelvic inclinometer apparatus that is based on the idea of measuring pelvic tilts with caliper. Further, reliability was also assessed for hand-held pelvic inclinometer with software application in a mobile cell device.

Statistical Analysis Used:
Cronbach's alpha (C-alpha) and intraclass correlation coefficient (ICC) were used to test reliability.

Results:
The intratester reliability of the tripod-mounted wooden arm inclinometer on both left (C-alpha - 0.98; ICC - 0.94) and right sides (C alpha - 0.97; ICC - 0.93) was high. Similar findings were noted with the hand-held inclinometer with smartphone software application, with intrarater reliability being high on both right (C-alpha - 0.98; ICC - 0.95) and left sides (C-alpha - 0.98; ICC - 0.96).

Conclusion:
Both the newly designed pelvic inclinometers, i.e., tripod-mounted wooden arm inclinometer and hand-held inclinometer with smartphone software application, are reliable and consistent for measuring pelvic inclination in the sagittal plane.
Depression, Anxiety, and Stress among Parents of Children with Special Needs during the COVID-19 Pandemic in Belagavi City
Authors: Metgud Deepa , Patil Chandana Suresh , Cotta Emika Ann 
Published: May 2024

Context:
Lockdown and social isolation during the pandemic situation caused an especially stressful situation for families with children with special educational needs and disabilities. The psychological repercussions on parents of these children remain unattended.

Aims:
The primary aim was to find the prevalence of depression, anxiety, and stress among parents of children with special needs during COVID-19 pandemic using Depression, Anxiety, and Stress Scale (DASS)-21. The secondary aim was to determine the correlation between the three domains of DASS-21 scale with the parent characteristics.

Settings and Design:
This was an observational study on parents of children with special needs visiting tertiary care center and special schools.

Subjects and Methods:
Eighty-seven parents of children with special needs participated Either parent of each child with special needs answered the questionnaire DASS-21. The total score of each participant was calculated for each component under each domain of the questionnaire.

Statistical Analysis Used:
Frequency distribution for occurrence of depression, anxiety and stress was analyzed. The linear associations were studied using correlation coefficient.

Results:
Out of 87 parents who participated in the study, 5.6% of the subjects had depression, 15.3% had anxiety, and 12.5% had stress. There was no significant correlation noted between individual domains of DASS-21 and the parent characteristics (P < 0.05).

Conclusion:
The study concludes that during the COVID-19 pandemic, the prevalence of depression, anxiety, and stress in parents of children with special needs was not significant. Further, no correlation was found between DASS-21 and the demographic characteristics of the parents.
Survey of the salt (NaCl) Contents of Traditional Breads in Tehran, 2016[FIGURE DASH]2018
Authors: Hadian Zahra , Fatemeh S. , Reihani S. , Mirmoghtadaie Leila , Tan Thuan Chew 
Published: May 2024

Background:
Considering the importance of non-communicable diseases (NCDs) in Iran, the aim of this study is to identify the trend in the salt (NaCl) levels of various types of traditional bread (sangak, barbari, taftoon, and lavash breads) in Tehran in 2016 and 2018 and its implication for public health.

Methods:
A total of 777 samples of various traditional breads were randomly collected from various districts located in Tehran in 2018. The salt content (expressed as g/100 g dry weight) in these breads were determined according to Volhard method. Results from this study were compared with those reported in 2016.

Results:
The present study indicated that the mean salt content in traditional breads in 2018 was significantly higher than that reported in 2016. Salt content in traditional breads collected in 2018 ranged from 0.03 to 6.52/100 g dry weight, with mean value of 1.43 g/100 g dry weight. When comparing with the permitted limit set by Institute of Standards and Industrial Research of Iran (ISIRI), there was an increase in the percentage of samples complying with the permitted limit; 50.8% (2016) vs 54.1% (2018).

Conclusions:
The daily salt intake increased from 1.56 g per person in 2016 to 2.31 g per person in 2018. Considering the high bread per capita consumption in Iran, it seems that half of the daily recommended salt intake could be reached exclusively through breads. Hence, the main strategies for salt intake reduction from bread could be achieved through evaluation of salt reduction programs and development of technological factors in bread baking.
The Association Between the Dietary Inflammatory Index (DII) and Some Serum Oxidative Stress Markers in Non-Alcoholic Fatty Liver Disease
Authors: Moradi Fateme , Heidari Zahra , Teimori Azam , Ghazvini Mohammadreza , Imani Zahra Faghih , Naeini Amirmansour Alavi 
Published: May 2024

Purpose:
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder. The purpose of this study was to determine the relationship between the dietary inflammatory index (DII) and the serum oxidative stress markers in patients with NAFLD.

Methods:
In this case-control study, 121 patients with NAFLD and 119 healthy subjects were frequency-matched on gender. DII scores were calculated by using a 168-item food frequency questionnaire (FFQ). Blood samples were collected to measure serum oxidative markers. Linear regression and odds ratio (OR) were also used in this study.

Results:
The mean ± standard deviation of age for case and control group was 38.04 ± 6.7 and 35.6 ± 10.2, respectively. The gender ratio (female to male) for the case and control group was 1:1.42 and 1:1.38, respectively. The mean of the DII in the patient group was significantly higher than the healthy group, (P-values < 0.01). There was a significant negative relationship between TAC and DII (B = -2.63 (95%CI: -4.59, -0.68) and there was also a positive relationship between Malondialdehyde (MDA) and DII (B = 0.15 (95%CI: 0.02, 0.28) in the healthy group, but they were not significant in the case group. After multivariate adjustment, subjects in the most pro-inflammatory DII group had 73 times higher odds of NAFLD compared to subjects in tertile 1 (OR = 72.9; 95%CI (14.3-371.9)).

Conclusions:
Our findings suggest a direct association between the pro inflammatory properties of diet in patient and healthy group, but no relationship between TAC, MDA, and DII in the case group.
Radiomorphometric Indices and their Relation to Alveolar Bone Loss
Authors: Bangar Bhushan R. , Rampati Sandhya R. , Gajare Susheen M. , Vanama Yamini , Tummala Sai S. , Vemulapalli Charita C. , Suresh B. J , Swarnalatha C , Nayyar Abhishek S. 
Published: May 2024

Aim:
To assess the influence of gender and age on different parameters of alveolar bone loss using specific radiomorphometric indices on panoramic radiographs to aid in identifying patients with possible low bone mineral density (BMD).

Materials and Methods:
The present cross-sectional study included 80 subjects in whom mandibular cortical index (MCI), mandibular cortical width (MCW), panoramic mandibular index (PMI), alveolar bone loss (ABL), and bone height in 1st premolar (Hp) and 1st molar (Hm) were assessed to evaluate the alveolar bone loss.

Results:
The findings of the present study revealed a significant association between MCI and age for females with C2 and C3 categories being more common with advancing age. Also, a significant difference could be seen in relation to gender (p-value = 0.0315) for MCW with a concomitant decrease in values of MCW in females >60 years of age. The vertical bone height of the edentulous mandible at 1st premolar (Hp) (p-value = 0.0071) and 1st molar (Hm) (p-value = 0.0044) regions were also found to be more in males than females.

Conclusion:
Panoramic radiographic measurements provided valuable information for alveolar bone loss in terms of gender and age based on specific radiomorphometric parameters.