bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal debulking surgery in ovarian cancer patients: MRI may predict the necessity of rectosigmoid resection
Authors: Zhao Xiaofang , Yang Ping , Liu Liu , Li Yi , Huang Yang , Tang Huali , Zhou Yin , Mao Yun 
Published: June 2024

Abstract
Objectives
To determine whether MRI can predict the necessity of rectosigmoid resection (RR) for optimal debulking surgery (ODS) in ovarian cancer (OC) patients and to compare the predictive accuracy of pre- and post-neoadjuvant chemotherapy (NACT) MRI.

Methods
The MRI of 82 OC were retrospectively analyzed, including six bowel signs (length, transverse axis, thickness, circumference, muscularis involvement, and submucosal edema) and four para-intestinal signs (vaginal, parametrial, ureteral, and sacro-recto-genital septum involvement). The parameters reflecting the degree of muscularis involvement were measured. Patients were divided into non-RR and RR groups based on the operation and postoperative outcomes. The independent predictors of the need for RR were identified by multivariate logistic regression analysis.

Results
Imaging for 82 patients was evaluated (67 without and 15 with NACT). Submucosal edema and muscularis involvement (OR 13.33 and 8.40, respectively) were independent predictors of the need for RR, with sensitivities of 83.3% and 94.4% and specificities of 93.9% and 81.6%, respectively. Among the parameters reflecting the degree of muscularis involvement, circumference ≥ 3/12 had the highest prediction accuracy, increasing the specificity from 81.6% for muscularis involvement only to 98.0%, with only a slight decrease in sensitivity (from 94.4% to 88.9%). The predictive sensitivities of pre-NACT and post-NACT MRI were 100.0% and 12.5%, respectively, and the specificities were 85.7% and 100.0%, respectively.

Conclusions
MRI analysis of rectosigmoid muscularis involvement and its circumference can help predict the necessity of RR in OC patients, and pre-NACT MRI may be more suitable for evaluation.

Critical relevance statement
We analyzed preoperative pelvic MRI in OC patients. Our findings suggest that MRI has predictive potential for identifying patients who require RR to achieve ODS.

Key Points

The need for RR must be determined to optimize treatment for OC patients.

Muscularis involvement circumference ≥ 3/12 could help predict RR.

Pre-NACT MRI may be superior to post-NACT MRI in predicting RR.

Graphical Abstract
The impact of hepatic and splenic volumetric assessment in imaging for chronic liver disease: a narrative review
Authors: Kutaiba Numan , Chung William , Goodwin Mark , Testro Adam , Egan Gary , Lim Ruth 
Published: June 2024

Abstract
Chronic liver disease is responsible for significant morbidity and mortality worldwide. Abdominal computed tomography (CT) and magnetic resonance imaging (MRI) can fully visualise the liver and adjacent structures in the upper abdomen providing a reproducible assessment of the liver and biliary system and can detect features of portal hypertension. Subjective interpretation of CT and MRI in the assessment of liver parenchyma for early and advanced stages of fibrosis (pre-cirrhosis), as well as severity of portal hypertension, is limited. Quantitative and reproducible measurements of hepatic and splenic volumes have been shown to correlate with fibrosis staging, clinical outcomes, and mortality. In this review, we will explore the role of volumetric measurements in relation to diagnosis, assessment of severity and prediction of outcomes in chronic liver disease patients. We conclude that volumetric analysis of the liver and spleen can provide important information in such patients, has the potential to stratify patients’ stage of hepatic fibrosis and disease severity, and can provide critical prognostic information.

Critical relevance statement
This review highlights the role of volumetric measurements of the liver and spleen using CT and MRI in relation to diagnosis, assessment of severity, and prediction of outcomes in chronic liver disease patients.

Key Points

Volumetry of the liver and spleen using CT and MRI correlates with hepatic fibrosis stages and cirrhosis.

Volumetric measurements correlate with chronic liver disease outcomes.

Fully automated methods for volumetry are required for implementation into routine clinical practice.

Graphical Abstract
Sexually dimorphic effects of prenatal alcohol exposure on the murine skeleton
Authors: Bourne Lucie E. , Jayash Soher N. , Michels Lysanne V. , Hopkinson Mark , Guppy Fergus M. , Clarkin Claire E. , Gard Paul , Brissett Nigel , Staines Katherine A. 
Published: June 2024

Abstract
Background
Prenatal alcohol exposure (PAE) can result in lifelong disabilities known as foetal alcohol spectrum disorder (FASD) and is associated with childhood growth deficiencies and increased bone fracture risk. However, the effects of PAE on the adult skeleton remain unclear and any potential sexual dimorphism is undetermined. Therefore, we utilised a murine model to examine sex differences with PAE on in vitro bone formation, and in the juvenile and adult skeleton.

Methods
Pregnant C57BL/6J female mice received 5% ethanol in their drinking water during gestation. Primary calvarial osteoblasts were isolated from neonatal offspring and mineralised bone nodule formation and gene expression assessed. Skeletal phenotyping of 4- and 12-week-old male and female offspring was conducted by micro-computed tomography (µCT), 3-point bending, growth plate analyses, and histology.

Results
Osteoblasts from male and female PAE mice displayed reduced bone formation, compared to control (≤ 30%). Vegfa, Vegfb, Bmp6, Tgfbr1, Flt1 and Ahsg were downregulated in PAE male osteoblasts only, whilst Ahsg was upregulated in PAE females. In 12-week-old mice, µCT analysis revealed a sex and exposure interaction across several trabecular bone parameters. PAE was detrimental to the trabecular compartment in male mice compared to control, yet PAE females were unaffected. Both male and female mice had significant reductions in cortical parameters with PAE. Whilst male mice were negatively affected along the tibial length, females were only distally affected. Posterior cortical porosity was increased in PAE females only. Mechanical testing revealed PAE males had significantly reduced bone stiffness compared to controls; maximum load and yield were reduced in both sexes. PAE had no effect on total body weight or tibial bone length in either sex. However, total growth plate width in male PAE mice compared to control was reduced, whilst female PAE mice were unaffected. 4-week-old mice did not display the altered skeletal phenotype with PAE observed in 12-week-old animals.

Conclusions
Evidence herein suggests, for the first time, that PAE exerts divergent sex effects on the skeleton, possibly influenced by underlying sex-specific transcriptional mechanisms of osteoblasts. Establishing these sex differences will support future policies and clinical management of FASD.
Empowering standardization of cancer vaccines through ontology: enhanced modeling and data analysis
Authors: Zheng Jie , Li Xingxian , Masci Anna Maria , Kahn Hayleigh , Huffman Anthony , Asfaw Eliyas , Pan Yuanyi , Guo Jinjing , He Virginia , Song Justin , Seleznev Andrey I. , Lin Asiyah Yu , He Yongqun 
Published: June 2024

Abstract
Background
The exploration of cancer vaccines has yielded a multitude of studies, resulting in a diverse collection of information. The heterogeneity of cancer vaccine data significantly impedes effective integration and analysis. While CanVaxKB serves as a pioneering database for over 670 manually annotated cancer vaccines, it is important to distinguish that a database, on its own, does not offer the structured relationships and standardized definitions found in an ontology. Recognizing this, we expanded the Vaccine Ontology (VO) to include those cancer vaccines present in CanVaxKB that were not initially covered, enhancing VO’s capacity to systematically define and interrelate cancer vaccines.

Results
An ontology design pattern (ODP) was first developed and applied to semantically represent various cancer vaccines, capturing their associated entities and relations. By applying the ODP, we generated a cancer vaccine template in a tabular format and converted it into the RDF/OWL format for generation of cancer vaccine terms in the VO. ‘12MP vaccine’ was used as an example of cancer vaccines to demonstrate the application of the ODP. VO also reuses reference ontology terms to represent entities such as cancer diseases and vaccine hosts. Description Logic (DL) and SPARQL query scripts were developed and used to query for cancer vaccines based on different vaccine’s features and to demonstrate the versatility of the VO representation. Additionally, ontological modeling was applied to illustrate cancer vaccine related concepts and studies for in-depth cancer vaccine analysis. A cancer vaccine-specific VO view, referred to as “CVO,” was generated, and it contains 928 classes including 704 cancer vaccines. The CVO OWL file is publicly available on: http://purl.obolibrary.org/obo/vo/cvo.owl, for sharing and applications.

Conclusion
To facilitate the standardization, integration, and analysis of cancer vaccine data, we expanded the Vaccine Ontology (VO) to systematically model and represent cancer vaccines. We also developed a pipeline to automate the inclusion of cancer vaccines and associated terms in the VO. This not only enriches the data’s standardization and integration, but also leverages ontological modeling to deepen the analysis of cancer vaccine information, maximizing benefits for researchers and clinicians.

Availability
The VO-cancer GitHub website is: https://github.com/vaccineontology/VO/tree/master/CVO.
Early diagnosis and staging of paraquat-induced pulmonary fibrosis using [18F]F-FAPI-42 PET/CT imaging
Authors: Zhang Dimei , Shi Yusheng , Kong Jiangwei , Chen Na , Li Guiting , Wang Mingfang , Zhang Guoxia , Zhai Chuangyan 
Published: June 2024

Abstract
Background
Paraquat (PQ) -induced pulmonary fibrosis poses a significant medical challenge due to limited treatment options and high mortality rates. Consequently, there is an urgent need for early diagnosis and accurate staging to facilitate appropriate treatment strategies. In this study, we assessed the diagnostic potential of [18F]F-FAPI-42 PET/CT imaging for early detection and disease staging in a rat model of PQ-induced lung fibrosis.

Methods
After administering 80 mg/kg of PQ orally to Sprague-Dawley rats, we intravenously injected 3-3.5 MBq of [18F]F-FAPI-42 on day 7, 14, and 21 post-dosing. Dynamic PET/CT imaging was carried out for one hour immediately after the administration of [18F]F-FAPI-42. Subsequently, the lung tissues were collected for Hematoxylin and Eosin (HE) staining, Masson’s trichrome staining, and NOTA-FAPI-04-MB fluorescent probe staining. Data analysis was performed using the Imalytics preclinical software, and the mean standardized uptake value (SUVmean) was calculated.

Results
PET signals revealed that in areas with evident lesions on CT, the SUVmean on day 14 was significantly higher than on day 7 and 21, indicating that changes in fibrosis activity levels contribute to the staging of pulmonary fibrosis. Additionally, the NOTA-FAPI-04-MB fluorescent probe staining also demonstrated the most pronounced probe uptake on day 14. In regions without apparent lesions on CT, the SUVmean gradually increased from day 7 to day 21, reflecting ongoing fibrotic activity. Moreover, HE staining and Masson’s trichrome staining did not reveal pulmonary fibrosis, while PET imaging was able to detect it, serving the purpose of early diagnosis. At 30 min and 60 min, the target-to-background ratio (TBR) of the PQ groups on day 7, 14, and 21 was significantly higher than the control group, suggesting a high specificity of [18F]F-FAPI-42 binding to activated fibroblasts.

Conclusion
[18F]F-FAPI-42 PET/CT imaging enables early diagnosis and staging of PQ-induced pulmonary fibrosis, demonstrating its feasibility and potential for characterizing early disease stages.
Bradykinin promotes immune responses in differentiated embryonic neurospheres carrying APPswe and PS1dE9 mutations
Authors: Juvenal Guilherme , Meinerz Carine , Ayupe Ana Carolina , Campos Henrique Correia , Reis Eduardo Moraes , Longo Beatriz Monteiro , Pillat Micheli Mainardi , Ulrich Henning 
Published: June 2024

Abstract
Background
Neural progenitor cells (NPCs) can be cultivated from developing brains, reproducing many of the processes that occur during neural development. They can be isolated from a variety of animal models, such as transgenic mice carrying mutations in amyloid precursor protein (APP) and presenilin 1 and 2 (PSEN 1 and 2), characteristic of familial Alzheimer’s disease (fAD). Modulating the development of these cells with inflammation-related peptides, such as bradykinin (BK) and its antagonist HOE-140, enables the understanding of the impact of such molecules in a relevant AD model.

Results
We performed a global gene expression analysis on transgenic neurospheres treated with BK and HOE-140. To validate the microarray data, quantitative real-time reverse-transcription polymerase chain reaction (RT-PCR) was performed on 8 important genes related to the immune response in AD such as CCL12, CCL5, CCL3, C3, CX3CR1, TLR2 and TNF alpha and Iba-1. Furthermore, comparative analysis of the transcriptional profiles was performed between treatments, including gene ontology and reactome enrichment, construction and analysis of protein-protein interaction networks and, finally, comparison of our data with human dataset from AD patients. The treatments affected the expression levels of genes mainly related to microglia-mediated neuroinflammatory responses, with BK promoting an increase in the expression of genes that enrich processes, biological pathways, and cellular components related to immune dysfunction, neurodegeneration and cell cycle. B2 receptor inhibition by HOE-140 resulted in the reduction of AD-related anomalies caused in this system.

Conclusions
BK is an important immunomodulatory agent and enhances the immunological changes identified in transgenic neurospheres carrying the genetic load of AD. Bradykinin treatments modulate the expression rates of genes related to microglia-mediated neuroinflammation. Inhibiting bradykinin activity in Alzheimer’s disease may slow disease progression.
Effects of exercise training on cardiac output in subjects with heart failure with preserved ejection fraction (HFpEF) — a protocol for a systematic review and meta-analysis
Authors: Schoch Raphael , Gasser Benedikt , Beck Philippe , Appenzeller-Herzog Christian , Schmidt-Trucksäss Arno 
Published: June 2024

AbstractBackgroundPatients with heart failure with preserved ejection fraction (HFpEF) commonly experience exercise intolerance, resulting in reduced cardiorespiratory fitness. This is characterised by a decreased maximal oxygen uptake (V̇O2peak), which is determined by the product of cardiac output (CO) and arteriovenous oxygen difference (a-vDO2). While exercise training has been shown to improve V̇O2peakin HFpEF patients, the effects on CO remain unclear. The aim of this study is to systematically review and analyse the current evidence on the effects of supervised exercise training on CO in patients with HFpEF.MethodsWe will systematically search for literature describing the effects of supervised exercise training on CO in patients with HFpEF. All eligible studies published before 30 June 2023 in the following electronic databases will be included: MEDLINE (Ovid), Embase (Ovid), SPORTDiscus (EBSCOhost), and CENTRAL (Cochrane Library). Effect sizes will be extracted for CO before and after a supervised exercise training intervention at rest and maximal exercise. Mass of heterogeneity (I2) will be calculated, and either fixed-effect models or random-effect models will be used for meta-analysis. To detect a potential publication bias, funnel plot analyses will be performed.DiscussionWhile several studies have reported a positive effect of supervised exercise training on cardiorespiratory fitness, attempts to assess the underlying determinants of V̇O2peak, CO, and a-vDO2are much scarcer, especially in patients with HFpEF. From a physiological perspective, measuring CO before and after supervised exercise training seems to be a reasonable way to accurately operationalise a potential improvement in cardiac function.Systematic review registrationPROSPERO CRD42022361485.
Weighted fractional inequalities for new conditions on h-convex functions
Authors: Benaissa Bouharket , Azzouz Noureddine , Budak Hüseyin 
Published: June 2024

AbstractWe use a new function class called B-function to establish a novel version of Hermite–Hadamard inequality for weighted ψ-Hilfer operators. Additionally, we prove two new identities involving weighted ψ-Hilfer operators for differentiable functions. Moreover, by employing these equalities and the properties of the B-function, we derive several trapezoid- and midpoint-type inequalities for h-convex functions. Furthermore, the obtained results are reduced to several well-known and some new inequalities by making specific choices of the function h.
Autumn sunlight promotes aboveground carbon loss in a temperate mixed forest
Authors: Li Xingzhi , Wang Yanan , Zhang Juanjuan , Robson Thomas Matthew , Kurokawa Hiroko , Peng Huan , Zhou Li , Yu Dapao , Deng Jiaojiao , Wang Qing-Wei 
Published: June 2024

Abstract
Background
Photodegradation of plant litter plays a pivotal role in the global carbon (C) cycle. In temperate forest ecosystems, the exposure of plant litter to solar radiation can be significantly altered by changes in autumn phenology and snow cover due to climatic change. How this will affect litter decomposition and nutrient dynamic interacting with forest canopy structure (understorey vs. gaps) is uncertain. In the present study, we conducted a field experiment using leaf litter of early-fall deciduous Betula platyphylla (Asian white birch) and late-fall deciduous Quercus mongolica (Mongolian oak) to explore the effect of change in autumn solar radiation on dynamics of litter decomposition in a gap and understorey of a temperate mixed forest.

Results
Exposure to the full-spectrum of not only significantly increased the loss of mass, C, and lignin, but also modified N loss through both immobilization and mineralization during the initial decomposition during autumn canopy opening, irrespective of canopy structure and litter species. These effects were mainly driven by the blue-green spectral region of sunlight. Short-term photodegradation by autumn solar radiation had a positive legacy effect on the later decomposition particularly in the forest gap, increasing mass loss by 16% and 19% for Asian white birch and Mongolia oak, respectively.

Conclusions
Our results suggest that earlier autumn leaf-fall phenology and/or later snow cover due to land-use or climate change would increase the exposure of plant organic matter to solar radiation, and accelerate ecosystem processes, C and nutrient cycling in temperate forest ecosystems. The study provides a reference for predictive research on carbon cycling under the background of global climate change.
Knowledge management and sustainable entrepreneurship: a bibliometric overview and research agenda
Authors: Alkathiri Nasser Alhamar , Said Foued Ben , Meyer Natanya , Soliman Mohammad 
Published: June 2024

AbstractThe current work highlights the evolution in knowledge management for sustainable entrepreneurship research by analyzing the key trends and major concepts. Additionally, the knowledge structures of such research themes were analyzed and mapped. Moreover, this paper seeks to present a research agenda concerning the study subject. It employed an integrated bibliometric approach and systematic review of knowledge management and sustainable entrepreneurship research by conducting two main procedures, namely domain analysis (i.e., key trends and evolution) and knowledge structures analysis (i.e., intellectual, social, and conceptual structure). A total of 233 documents were obtained from Scopus and Web of Science datasets and analyzed using both R 4.1.2 and VOSviewer software. The findings demonstrated that the contributors (i.e., the authors, nations, journals, and institutions) produced a discernible evolution in the body of knowledge on the themes of knowledge management and sustainable business within the designated period. Furthermore, science mapping approaches deeply grasp the social, conceptual, and intellectual structures of such research themes. This current work is considered one of the first attempts to systematically review, analyze, and visualize the scientific productions on knowledge management and sustainable entrepreneurship. The findings of the current work also offer a solid understanding and insights into the potential directions for the research agenda in these disciplines.
Automated surveillance of antimicrobial consumption in intensive care, northern Sweden: an observational case study
Authors: Winroth Andreas , Andersson Mattias , Fjällström Peter , Johansson Anders F. , Lind Alicia 
Published: June 2024

AbstractBackgroundThe digitalization of information systems allows automatic measurement of antimicrobial consumption (AMC), helping address antibiotic resistance from inappropriate drug use without compromising patient safety.ObjectivesDescribe and characterize a new automated AMC surveillance service for intensive care units (ICUs), with data stratified by referral clinic and linked with individual patient risk factors, disease severity, and mortality.MethodsAn automated service collecting data from the electronic medical record was developed, implemented, and validated in a healthcare region in northern Sweden. We performed an observational study from January 1, 2018, to December 31, 2021, encompassing general ICU care for all ≥18-years-olds in a catchment population of 270000 in secondary care and 900000 in tertiary care. We used descriptive analyses to associate ICU population characteristics with AMC outcomes over time, including days of therapy (DOT), length of therapy, defined daily doses, and mortality.ResultsThere were 5608 admissions among 5190 patients with a median age of 65 (IQR 48-75) years, 41.2% females. The 30-day mortality was 18.3%. Total AMC was 1177 DOTs in secondary and 1261 DOTs per 1000 patient days and tertiary care. AMC varied significantly among referral clinics, with the highest total among 810 general surgery admissions in tertiary care at 1486 DOTs per 1000 patient days. Case-mix effects on the AMC were apparent during COVID-19 waves highlighting the need to account for case-mix. Patients exposed to more than three antimicrobial drug classes (N= 242) had a 30-day mortality rate of 40.6%, with significant variability in their expected rates based on admission scores.ConclusionWe introduce a new service and instructions for automating local ICU-AMC data collection. The versatile long-term ICU-AMC metrics presented, covering patient factors, referral clinics and mortality outcomes, are expected to be beneficial in refining antimicrobial drug use.