bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mapping Neuroimaging Findings of Creativity and Brain Disease Onto a Common Brain Circuit
Authors: Kutsche Julian , Taylor Joseph J. , Erkkinen Michael G. , Akkad Haya , Khosravani Sanaz , Drew William , Abraham Anna , Ott Derek V. M. , Wall Juliana , Cohen Alexander Li , Horn Andreas , Neumann Wolf-Julian , Kletenik Isaiah , Fox Michael D. 
Published: February 2025

ImportanceCreativity is important for problem solving, adaptation to a changing environment, and innovation. Neuroimaging studies seeking to map creativity have yielded conflicting results, and studies of patients with brain disease have reported both decreases and paradoxical increases in creativity, leaving the neural basis of creativity unclear.ObjectiveTo investigate the brain circuit underlying creativity and assess its association with brain injury and neurodegenerative disease.Design, Setting, and ParticipantsThis study examined neuroimaging coordinates from a meta-analysis of 36 studies published between 2004 and 2019 associated with increased activity during creative tasks in healthy participants. A validated method termed coordinate network mapping and a database of resting-state functional connectivity from 1000 healthy individuals were used to test whether these coordinates mapped to a common brain circuit. Specificity was assessed through comparison to random coordinates and coordinates from working memory tasks in healthy participants. Reproducibility was assessed using an independent dataset of coordinates from additional studies of creativity in healthy participants. Finally, alignment with effects of focal brain damage on creativity was tested using data from patients with brain lesions and coordinates of brain atrophy from 7 different neurodegenerative disorders.Main Outcomes and MeasuresThe primary outcomes were creativity or no creativity and alignment with a creativity circuit or no alignment.ResultsCreativity tasks activated heterogenous locations, with coordinates scattered across many different brain regions (415 coordinates derived from 857 healthy participants; pooled mean [SD] age, 24.1 [6.91] years; 461 [54%] female). However, these activation coordinates were part of a common brain circuit, defined by negative connectivity to the right frontal pole. This result was consistent across creative domains, reproducible in an independent dataset (383 coordinates derived from 691 participants) and specific to creativity when compared with random gray matter coordinates (n = 415) or coordinates activated by working memory tasks (3072 coordinates derived from 2900 healthy participants). Damage to this creativity circuit by lesions (n = 56 patients) or neurodegenerative disease (2262 coordinates derived from 4804 patients) aligned with both decreases and increases in creativity observed in these disorders.Conclusions and RelevanceFindings from this study suggest that brain regions activated by creativity tasks map to a brain circuit defined by negative functional connectivity to the right frontal pole. Damage to this circuit aligned with changes in creativity observed in individuals with certain brain diseases, including paradoxical creativity increases.
Robust automated method of spatial resolution measurement in radiotherapy CT simulation images
Authors: Govyadinov Pavel , Layman Rick. R. , Netherton Tucker , Mumme Raymond , Jones Aaron. K. , Court Laurence. E. , Ahmad Moiz 
Published: February 2025

AbstractBackgroundVariation in imaging protocol, patient positioning, and the presence of artifacts can vary image quality in CT images used for radiotherapy planning. Automated methods for spatial resolution (SR) estimation exist but require further investigation and validation for wider adoption.PurposeTo validated previously existing algorithm for SR estimation and introduce improvements that make it robust to patient positioning, CT protocol, site, and artifacts.MethodA reference algorithm based on the previous gold standard was recreated and modified to improve robustness. The algorithms were tested on three different datasets: (1) a cylindrical ACR CT QC phantom scanned using a Siemens SOMATOM Definition Edge scanner and reconstructed using 61 different kernels, (2) a set of anthropomorphic phantoms scanned with the presence of artifacts common to clinical acquisitions such as blankets and immobilization devices, and (3) a clinical patient dataset of head and neck (HN) CT scans (nine patients) and spine/pelvis (10 patients). The robustness of both algorithms was tested on the clinical patient data.ResultsOver the range of tested kernels, both algorithms were accurate when the ground truth MTF f50 was within the range 0.2–0.7 mm−1 in the cylindrical phantom datasets with an RMS error of 10.3% and 3.8% for the reference and modified versions of the algorithm, respectively, as compared to the ground truth. In the anthropomorphic phantom datasets the reference algorithm showed an 8.4% and 30.0% difference from ground truth for the Pelvic and HN phantoms, respectively, while the modified algorithm showed 4.9% and 3.9% percent difference from ground truth. In the clinical dataset the reference algorithm estimated a mean f50 value of 0.21 ± 0.03 mm−1 and 0.25 ± 0.03 mm−1 for pelvis/spine while the reference algorithm estimated mean of 0.28 ± 0.02 and 0.29 ± 0.01 mm−1 for HN and pelvis/spine, respectively, as compared to the ground truth found to be 0.28 mm−1 on the cylindrical phantom.ConclusionThe SR algorithm was validated cylindrical/anthropomorphic phantoms and clinical CT scans. Further modifications were tested and showed improved accuracy in more challenging CT acquisitions.
The Fertile Ground Between Sustainability and Religious Education
Authors: Windsor Sally , Franck Olof 
Published: February 2025

Abstract
This chapter introduces the aims of this book and the chapter contributions that are contained within. It identifies a gap in the research that scrutinises the types of education that sit at the nexus of religious education and sustainability education and argues that the core of both of these forms of education should be to enhance the ‘ethical literacy’ of students for a sustainable future.
Reframing the Human–Nature Relationship in Worldview Education: The Case of Finnish Lutheran and Orthodox Textbooks
Authors: Zilliacus Harriet , Wolff Lili-Ann , Mikander Pia , Kallioniemi Arto 
Published: February 2025

Abstract
To support new ways of thinking and acting that could create sustainable lifestyles and societies, it is necessary to consider how education attends to the human relationship with the non-human world. In this study, we investigated how the human–nature relationship introduced into Finnish worldview education in the initial comprehensive school years. Through discourse analysis grounded in Laclau and Mouffe, we examined textbooks in Lutheran and Orthodox religious education from 2015 to 2022. Our focus was on how textbooks support international policy and the curricular aims of sustainability in Finland. The results showed that the textbooks introduced the human–nature relationship through a distinct view of separation and dualism between humans and non-human nature. Discourses that might support a change in the human–nature relationship were not found. Given the policy and curricular aims, this raises the concern whether Finnish worldview education can encourage students to recognize the interconnectedness of all life and humans’ complete dependence on viable ecosystems. There is a substantial and pressing need for the development of textbooks to provide more opportunities to learn about various human–nature relationships and to re-imagine new ones, as well as to encourage student agency with respect to the sustainability crisis.
Indigenous Spirituality with a Focus on Maya Religion and Ritual Practices in Connection with Education on Sustainable Development in RE Classrooms
Authors: Liljefors Persson Bodil 
Published: February 2025

Abstract
This contribution has two purposes. It aims at grasping Indigenous religions with an emphasis on Maya religious discourse seen in long term perspective and aims to give examples of how teaching about ecology, sustainability and global ethics and values can benefit from connecting to Indigenous religious traditions rituals within Religious Education. Questions of powerful knowledge and religious literacy are also discussed in this context.
Central themes in Maya cosmology, mythology and rituals will be highlighted together with the viability of Maya view on nature, agriculture, ecology and thus sustainability. Local knowledge of agriculture and ethnobotany, as well as ritual healing ceremonies are handed down from ancient traditions and still visible in present everyday life. These ritual practices today still communicate meaning and spirituality in the Maya area.
Knowledge of Indigenous religions and spirituality, exemplified by the case of Maya cosmology and ritual practices, will deepen understanding of processes of change and permanence and thus of sustainability. The objective is to emphasise the importance of integrating questions of sustainability and ecology in RE classrooms and to encourage future teachers in RE to develop their knowledge on the relations between religion(s) and sustainability.
Comparative evaluation of the performance of orthodontic retainers using different surface protocols: an in vitro study
Authors: Kurnaz Merve , Nazan Ali Arslan , Eraydın Feyza 
Published: February 2025

Abstract
This study aims to assess the in vitro durability of Nitinol retainers, manufactured using computer-aided methods with hydrophilic or superhydrophilic surfaces to reduce debonding, alongside a commonly used composite adhesive. The 112 lower incisor teeth were embedded in blocks in pairs. Retainer wires were made up of 0.018 × 0.018 inch Nickel Titanium alloy(G4™ Nickel Titanium G&H Orthodontics, USA) by bending a robot arm. A total of 16 teeth(8 blocks) were used for each of the mentioned 7 groups Ni-Ti Retainer; Laser Textured Ni-Ti Retainer; Laser Texturing and Atmospheric Plasma Applicated Ni-Ti Retainer; Atmospheric Plasma Applicated Ni-Ti Retainer; Laser Texturing and Atmospheric Plasma Applicated Ni-Ti Retainer*2; Laser Texturing and Atmospheric Plasma Applicated Ni-Ti Retainer*3; SS-0.0018“(Morelli, Brazil). Transbond LR(3 M Unitek, California) was used. The shear bond strength tests were conducted. The Kruskal-Wallis H test was employed, pairwise comparisons followed by Dunn’s test with Bonferroni correction as a post-hoc analysis. There was no statistically significant difference between the groups for maximum force and maximum stress(p > 0.05). However, a significant difference was found in maximum elongation (p:0.0023). Pairwise comparisons highlighted significantly higher elongation values in the SS-0.0018” group. The stainless-steel wire demonstrated higher elongation values, which may offer clinical advantages in cases with higher occlusal forces and periodontal problems due to its material flexibility. Laser Texturing and Atmospheric Plasma Applied Ni-Ti Retainers exhibited higher test performance. Surface treatments applied to CAD/CAM retainers can provide an advantage by enhancing bond strength, potentially reducing the risk of debonding. These findings underline the importance of material selection and surface treatments in optimizing fixed retention strategies for long-term clinical success.
Impact of pharmacist-physician collaboration on patient outcomes in Parkinson’s disease: a randomised controlled trial in tertiary care
Authors: Techa-angkoon Phanutgorn , Pitakpatapee Yuvadee , Saengphatrachai Weerawat , Srivanitchapoom Prachaya , Suansanae Thanarat 
Published: February 2025

Abstract

Background
Previous studies have shown that reducing drug-related problems (DRPs) may improve therapeutic outcomes in patients with Parkinson’s disease (PD).

Aim
To investigate the impact of pharmacist participation in Parkinson’s disease clinic on the number of DRPs, clinical outcomes, and the quality of life of PD patients.

Method
This single-blinded randomised controlled trial was conducted at the Parkinson’s Disease and Movement Disorders Clinic. Patients aged ≥ 18 years, diagnosed with idiopathic PD for at least 3 years, and receiving antiparkinsonian drugs were randomly assigned (1:1) to the pharmacist-physician (PP) or usual care (UC) groups. The primary outcome was changes in the number of DRPs from baseline to 24 weeks between groups. Secondary outcomes included the Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) score, eight-item version of the Parkinson’s Disease Questionnaire (PDQ-8) score, and Patients’ Global Impression of Change (PGIC) score at week 24.

Results
A total of 80 patients were randomised, with 40 in each group. The mean number of DRPs reduced in both groups; however, the reduction was greater in the PP group compared to the UC group (− 7.2 ± 3.6 vs. − 3.0 ± 1.8, p < 0.001), especially non-adherence issues. The MDS-UPDRS and PDQ-8 scores showed significantly greater improvement in the PP group. A higher proportion of patients in the PP group achieved improvement in PGIC scales compared to those in the UC group.

Conclusion
Our findings demonstrated that pharmacist-physician collaboration service in the PD clinic positively impacted patient outcomes.

Trial registration
ClinicalTrials.gov NCT05410210 (date 13 May 2022).
Measuring thymic output across the human lifespan: a critical challenge in laboratory medicine
Authors: Middelkamp Vera , Kekäläinen Eliisa 
Published: February 2025

Abstract
Age-associated thymic involution leads to a significant decline in thymic T cell output, a major contributor to immunosenescence in the elderly. Accurately measuring thymic output is therefore critical for understanding the mechanisms behind immune aging. Furthermore, robust quantification of thymic output is essential in various other clinical and research settings, including the diagnosis of immunodeficiencies and the monitoring of T cell reconstitution following therapeutic interventions like hematopoietic stem cell transplantation. Current methodologies for measuring thymic output include T cell receptor excision circle (TREC) quantification via quantitative polymerase chain reaction and the enumeration of recent thymic emigrants (RTEs) using flow cytometry. However, TREC-based assays are inherently insensitive to subtle changes in thymic output, limiting their applicability beyond neonatal immunodeficiency screening. Similarly, RTE enumeration presents challenges; while surface markers exist for CD4⁺ RTEs, validated markers for CD8⁺ cytotoxic T lymphocytes are lacking. This represents a significant knowledge gap, particularly as aging has been shown to disproportionally affect the CD8 T cell pool. Moreover, while flow cytometry effectively measures mature naïve T cells, these cells do not accurately represent real-time thymic output, as they can persist in peripheral circulation for extended periods. These limitations highlight the pressing need for more accurate and sensitive methods to assess thymic output. Improved measurement techniques would not only enhance our understanding of thymic involution in the context of aging but also enable large-scale investigations into thymic function and the mechanisms driving its decline in both health and disease. In this review, we examine current methodologies for measuring thymic output in humans, critically evaluate their limitations, and discuss emerging approaches to address these gaps in the field.
Tellurium Oxides: Thermodynamics and Phase Relations in the Te–O System
Authors: Gossé S. 
Published: February 2025

Abstract
The Te–O phase diagram and the TeO2 thermodynamic properties are of interest for many industrial fields: nuclear applications, steel making industry and chalcogenide glass processes. Both, the thermodynamic properties and phase diagram of this relevant binary system were reviewed and assessed using the Calphad method. From this assessment, the standard Gibbs free energy and corresponding heat capacity of the binary oxides are calculated as:

$$\begin{gathered} \Delta_{{\text{f}}} {\text{G}}_{{{\text{TeO}}_{2} }}^{ \circ } \left( {{\text{KJ}} \cdot {\text{mol}}^{ - 1} } \right) = - 109.646 + 0.1034 \cdot T - 0.0064 \cdot T \cdot \ln (T) \hfill \\ {\text{C}}_{{{\text{p}}_{{{\text{TeO}}_{2} }} }} \left( {{\text{J}} \cdot {\text{K}} \cdot {\text{mol}}^{ - 1} } \right) = 19.59 + 0.0101 \cdot {\text{T}} - 1.6 \cdot 10 ^{- 6}.T^{2} - 186517 \cdot T^{ - 2} \hfill \\ \end{gathered}$$

Δ
f

G

TeO
2

∘

KJ
·

mol

-
1

=
-
109.646
+
0.1034
·
T
-
0.0064
·
T
·
ln

(
T
)

C

p

TeO
2

J
·
K
·

mol

-
1

=
19.59
+
0.0101
·
T
-
1.6
·

10

-
6

.

T
2

-
186517
·

T

-
2

$$\begin{gathered} \Delta_{{\text{f}}} {\text{G}}_{{{\text{Te}}_{2} {\text{O}}_{5} }}^{ \circ } \left( {{\text{KJ}} \cdot {\text{mol}}^{ - 1} } \right) = - 104.81 + 0.1175 \cdot T - 0.0077 \cdot T \cdot \ln (T) \hfill \\ {\text{C}}_{{{\text{p}}_{{{\text{Te}}_{2} {\text{O}}_{5} }} }} \left( {{\text{J}} \cdot {\text{K}}^{ - 1} \cdot {\text{mol}}^{ - 1} } \right) = 19.86 + 0.0091 \cdot T - 285181 \cdot T^{ - 2} \hfill \\ \end{gathered}$$

Δ
f

G

Te
2

O
5

∘

KJ
·

mol

-
1

=
-
104.81
+
0.1175
·
T
-
0.0077
·
T
·
ln

(
T
)

C

p

Te
2

O
5

J
·

K

-
1

·

mol

-
1

=
19.86
+
0.0091
·
T
-
285181
·

T

-
2

$$\begin{gathered} \Delta_{{\text{f}}} {\text{G}}_{{{\text{TeO}}_{3} }}^{ \circ } \left( {{\text{KJ}} \cdot {\text{mol}}^{ - 1} } \right) = - 92.79 + 0.111 \cdot T - 0.00776 \cdot T \cdot \ln (T) \hfill \\ {\text{C}}_{{{\text{PTeO}}_{3} }} \left( {{\text{J}} \cdot {\text{K}}^{ - 1} \cdot {\text{mol}}^{ - 1} } \right) = 17.475 + 0.013 \cdot {\text{T}} - 2.085 \cdot 10^{ - 6} \cdot T^{2} - 280000 \cdot T^{ - 2} \hfill \\ \end{gathered}$$

Δ
f

G

TeO
3

∘

KJ
·

mol

-
1

=
-
92.79
+
0.111
·
T
-
0.00776
·
T
·
ln

(
T
)

C

PTeO
3

J
·

K

-
1

·

mol

-
1

=
17.475
+
0.013
·
T
-
2.085
·

10

-
6

·

T
2

-
280000
·

T

-
2
Enhancing Societal Value of Early Warning Early Action and Anticipatory Action Frameworks Using NOAA’s Oceanic Niño Index
Authors: Glantz Michael H. , Ramírez Ivan J. 
Published: February 2025

Abstract
Given the contemporary increase in the frequency, intensity, and duration of extreme anomalous hydromet hazards (droughts, floods, tropical storms, heatwaves), heightened attention of governments, scientists, media, and humanitarian organizations is being given to hydromet early warning systems. The focus of this article is multidisciplinary and multifaceted: it involves connecting an earliest warning indicator associated with the Oceanic Niño Index, one that complements the existing National Oceanic and Atmospheric Administration indicator, with early warning early action and anticipatory action approaches for disaster risk reduction (DRR). This new indicator in theory at least could increase the lead time between the release of an official forecast of an El Niño and the first appearance of its adverse impacts, thereby serving as the earliest warning of an event. As such, this DRR research links new usable earliest warning information, providing additional time to initiate tactical actions to cope with El Niño-spawned hydromet hazards. Integrating an earliest indicator of the likely onset of an El Niño into early action frameworks would hasten humanitarian assistance by providing at-risk communities and humanitarian organizations with more time to consider a range of options for responding to El Niño’s impacts.
Synthetic aspects, structural insights and pharmacological potential of pyrazole derivatives: an overview
Authors: Menezes Rachel Alveera , Bhat K. Subrahmanya 
Published: February 2025

Abstract
There is an increase in infectious diseases every year. Heterocyclic compounds have been in use as drugs for a long time. Amongst many heterocyclic derivatives, the drugs containing the pyrazole core has been in limelight because of its relative ease of synthesis and excellent biological activities. Pyrazoles are aromatic compounds consisting of ring structure where two nitrogen atoms are adjacent to each other and contain three carbon atoms. Over the years pyrazoles have been explored for a variety of pharmacological applications. Herein, this review overviews the information related to industrially important pyrazoline scaffolds and their applications, recent literature on synthesizing the pyrazole derivatives, providing an explanation for their biological activity by focusing on their structural activity relationship and hence affording ideas to design the compounds containing pyrazole scaffolds.

Graphical abstract
Poets, Resistance, Translation, and Ethics in a Time of War
Authors: Sandler Stephanie 
Published: February 2025

AbstractPoetry has proven a productive aesthetic discourse for those working in Russian and in Ukrainian, documented by a huge outpouring of verse and by both the articles in this forum. This viewpoint piece zeroes in on the ways in which poems have become a means of resistance, particularly for those writing in Russian, and on the roles played by translation as its own ethical act and as a form of further resistance. It ends with the example of Igor’ Bulatovskii's poetry and his broader actions as translator and editor.
Global Warming Is Likely Affecting Regional Drought Across Eurasia
Authors: Marvel Kate , Cook Benjamin I. , Cook Edward 
Published: February 2025

AbstractWhile rising global temperatures have altered global drought risk and are projected to continue to change large‐scale hydroclimate, it has proved difficult to detect the influence of external factors on drought‐relevant variables at regional scales. In addition to the inherent difficulty in identifying signals in noisy data, detection and attribution studies generally rely on general circulation models, which may fail to accurately capture the characteristics of naturally forced and internal hydroclimate variability. Here, we use a long tree‐ring based paleoclimate record of drought to estimate pre‐industrial variability in the Palmer Drought Severity Index (PDSI), a commonly used metric of drought risk. Using a Bayesian framework, we estimate the temporal and spatial characteristics of hydroclimate variability prior to 1850. We assess whether observed twenty‐first century PDSI is compatible with this pre‐industrial variability or is better explained by a forced response that scales with the global mean temperature. Our results suggest that global warming likely contributed to dry PDSI in Eastern Europe, the Mediterranean, and Arctic Russia and to wet PDSI in Northern Europe, East‐central Asia, and Tibet.