bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengenalan Metode Tilawati pada Jama’ah Pengajian Musholla Nurul Iman di Desa Mekar Sari Kecamatan Tanjung Raya Kabupaten Mesuji Provinsi Lampung
Authors: Afifah Noor , Nopriansyah Untung , Agustina Irani , Adyan Asyrofal , Hidayat Ananda 
Published: June 2024

This article contains the results of research during the community service period in Mekar Sari Village, Tanjung Raya District, Mesuji Regency, Lampung Province. Based on the results of observations when participating in the routine recitation activities of the Nurul Iman prayer room, there are several problems and one of them is the lack of interest in learning and reading the Koran by mothers in Mekar Sari village which is one of the problems that is the focus of this article's research. The use of inappropriate methods in a lesson can cause learning outcomes to be less than optimal. The application of the tilawati method is an alternative in increasing the motivation and ability of mothers to read the Qur'an. The principle of teaching the Qur'an using the tilawati method is that it is taught practically using the rost song, taught in a classical manner, taught in groups with reading and listening techniques using the Al-Qur'an. The implementation of Al-Qur'an learning using the tilawati method in the prayer congregation of the Nurul Iman musholla has had the effect of changing the ability of mothers to read the Al-Qur'an. Supporting factors and inhibiting factors for learning the Qur'an with the tilawati method are influenced by technical and field conditions, as well as the conditions of the recitation congregation. From this it is hoped that the interest and ability of the women in the prayer congregation at the Nurul Iman prayer room can increase so that learning outcomes are more effective and of good quality.
Impact of Pressure-Dependent Interfacial Tension and Contact Angle on Capillary Heterogeneity Trapping of CO2 in Storage Aquifers
Authors: Ren Bo , Littlefield James , Jia Cunqi , Ni Hailun , Duncan Ian 
Published: June 2024

Summary
Carbon dioxide (CO2) capillary trapping increases the total amount of CO2 that can be effectively immobilized in storage aquifers. This trapping, manifesting itself as accumulated CO2 columns at a continuum scale, is because of capillary threshold effects that occur below low-permeability barriers. Considering that capillary pressure is dictated by heterogeneous pore throat size, the trapped CO2 column height and associated CO2 saturation will vary spatially within a storage aquifer. This variation will be influenced by two pressure-dependent interfacial parameters—CO2/brine interfacial tension (IFT) and CO2/brine/rock contact angle. Our objective is to understand how the pressure dependence of these two parameters affects the heterogeneity of capillary trapped CO2 at a continuum scale.
Our conceptual model is a 1D two-zone system with the upper zone being a flow barrier (low permeability) and the lower zone being a flow path (high permeability). The inputs to this model include microfacies-dependent capillary pressure vs. saturation curves and permeability values. The input capillary pressure curves were collected in the literature that represents carbonate microfacies (e.g., dolograinstone) in a prevalent formation in the Permian Basin.
We then used the Leverett j-function to scale the capillary pressure curve for the two zones that are assigned with the same or different microfacies. During scaling, we considered the influence of pressure on both the IFT and contact angle of CO2/brine/dolomite systems. We varied the zone permeability contrast ratio from 2 to 50. We then assumed capillary gravity equilibriums and calculated the CO2 saturation buildup corresponding to various trapped CO2 column heights. The CO2 saturation buildup is defined as the CO2 saturation in the lower layer minus that in the upper one.
We found that the saturation buildup can be doubled when varying pressure in a storage aquifer, after considering pressure-dependent IFT and contact angles. Thus, assuming these two parameters to be constant across such aquifers would cause large errors in the quantification of capillary trapping of CO2. The whole study demonstrates the importance of considering pressure-dependent interfacial properties in predicting the vertical distribution of capillary trapped CO2. It has important implications in developing a better understanding of leakage risks and consequent storage safety.
Effect of exercise and Yoga program on renin-angiotensin mechanism in cardiac autonomic neuropathy in Diabetes mellitus patients.
Authors: Hulke Sandip Meghnad , Khadanga Sagar , Kotnis Ashwin Laxmikant , Thakare Avinash Eknath , Parashar Rachna , Bharshankar Rajay , Wakode Santosh , Mishra Shweta 
Published: June 2024

Abstract

Background: Cardiac autonomic neuropathy (CAN) is one of the frequent complications of diabetes mellitus. Renin-angiotensin mechanism play role in the development of CAN which may be affected by exercise as well as yoga. Aim of the study was to study the effect of a 6-month supervised exercise program/ Yoga program on cardiac autonomic neuropathy (CAN) status and renin angiotensin (RAAS) parameters in a diagnosed case of CAN in Diabetes mellitus patients.
Method: Diagnosed patients with CAN in diabetes mellitus would be randomly divided into two groups. One group will undergo a supervised exercise program and the other would follow a supervised YOGA program. CAN parameters and RAS mechanism parameters would be assessed before and after the start of the exercise/Yoga program. CAN parameters and RAAS parameters would be assessed using a cardiac autonomic function test battery and measurement of Plasma renin, Serum aldosterone, Angiotensin II, ACE, and Angiotensin (1-7) respectively.
Discussion: The effect of exercise on cardiac autonomic function has been assessed, however, these studies are limited, the strength of evidence is low, and the need for RCT was stressed. How does exercise affect the RAS mechanism? There are limited studies in this area. Further various research has been recommended to study various components of the RAS mechanism. In India, work has been done mainly to assess the effect of the YOGA program on cardiac autonomic function in diabetes mellitus. There are no uniform findings. Further, literature regarding its effect on the RAS mechanism is limited. Internationally, work is focused on various exercise programs, while the focus was on the yoga program in India. There is a need to assess the effect of such a supervised program on the Indian population.
Trial registration: Registered with clinical trial registry of India and registration number is CTRI/2023/05/052268, registered retrospectively Keywords: Diabetes mellitus, cardiac autonomic neuropathy, angiotensin, rennin
Ultrafast optical switching to a heterochiral charge-density wave state
Authors: Ropers Claus , Huang Wayne , Mu Sai , von Witte Gevin , Li Yanshuo , Kurtz Felix , Hung Sheng-Hsiung , Jeng Horng-Tay , Rossnagel Kai , Horstmann Jan 
Published: June 2024

Abstract

Optical control of correlated electronic states promises unprecedented tunability of novel functional materials [1-3]. Tailored optical excitations can steer a system along non-equilibrium pathways to metastable states with specific structural or electronic properties [4-6]. A much-desired feature is the reproducible and ultrafast switching to functional states. The light-induced hidden state of 1T-TaS2, with its strongly enhanced conductivity and exceptionally long lifetime, represents a unique model system for studying the switching of correlated electronic states using femtosecond optical stimuli. [4-7] However, despite intense investigation, the switching mechanism and the structural origins of the distinctive electronic properties of the hidden state have not been fully uncovered. Here, we use surface-sensitive electron diffraction in combination with a femtosecond optical quench to reveal coexistent charge-density wave chiralities as a new structural feature of the hidden state. We find that a single-pulse optical quench produces a state with long-range structural order and different weights of the two chiral enantiomorphs of the charge-density wave. Harnessing a double-pulse optical quench [5, 7-9], we trace the origin of the mixed chirality to the transient electronic excitation of the host crystal. The coexistent long-range-order of both chiralities suggests the presence of extended heterochiral charge-density wave interfaces, which results in a higher-level, fractal-type moiré superstructure. Density functional theory simulations for such a charge-density wave moiré superstructure reveal multiple flat bands, Dirac cones, and a kagome electronic subsystem around the Fermi energy. Our findings shed light on novel electronic properties gained by chiral interface engineering, and create avenues for light-induced moiré superstructures in quasi-two-dimensional materials.
Optimal Lymph node yield for long-term survival in elderly patients with right-sided colon cancer: a large population-based cohort study
Authors: Liu Tianyi , Jiao Shuai , Gao Shan , Shi Yan 
Published: June 2024

Abstract

Background
Although the recommended minimal lymph node yield (LNY) in colon cancer is 12, this standard remains controversial in elderly patients with right-sided colon cancer (RSCC) due to insufficient evidence. This study aims to clarify this issue by assessing the relationship between LNY and long-term survival in elderly patients with RSCC.
Methods
Data from the SEER database (split into 7:3 training and testing sets) and patients from the colorectal surgery departments of two tertiary hospitals in China (validation set) were analyzed. Elderly patients with stages I-III RSCC undergoing resection were included. The correlation between LNY and overall survival (OS) was evaluated by a multivariate model and the application of the restricted cubic spline curve (RCS). The odds ratios (ORs) for stage migration and the hazard ratios (HRs) for OS with increased LNY were estimated using Locally Weighted Scatterplot Smoothing (LOWESS), with structural breakpoints identified using the Chow test.
Results
The distribution of LNY was similar across the training (median: 18, IQR [14, 23]), testing (median: 18, IQR [14, 23]), and validation (median: 17, IQR [14, 20]) sets. Increasing LNY was associated with significantly improved OS in all datasets (Training set: HR = 0.983; Testing set: HR = 0.981; Validation set: HR = 0.944, all P < 0.001) after adjusting for confounders. Cut-point analysis identified an optimal LNY threshold of 18, validated across datasets, effectively discriminating survival probabilities.
Conclusions
A higher LNY is associated with improved survival. Our findings robustly support 18 LNYs as the optimal threshold for assessing the quality of lymph node dissection and prognosis stratification in elderly patients with RSCC.
Mechanical properties and acoustic emission characteristics of basalt fiber reinforced cemented silty sand subjected to freeze-thaw cycles
Authors: Sun Shuang , Liu Xue , Liu Hanbing , Shi Chenglin , Xu Lina , Huang Zhanfang , Sui Yongqiang 
Published: June 2024

Abstract

Freeze-thaw (F-T) cycling was a crucial issue in seasonal frozen zones and it will significantly influence the mechanical properties of soil, which must be strictly considered for subgrade engineering. Therefore, a series of unconfined compression test was conducted to analyze the effects of multiple factors i.e., fiber content, fiber length, curing time and F-T cycles on unconfined compression strength (UCS), as well as find the optimal ratio of fiber reinforced cemented silty sand. Meanwhile, based on the optimal ratio, AE test was adopt to further evaluate the AE characteristic parameters (i.e. cumulative ring count and cumulative energy, energy, amplitude, RA and AF) of fiber reinforced cemented silty sand subjected to F-T cycles, to reveal the F-T damage process. The results showed that the UCS first increased and then decreased with the increase of fiber content, increased with the increase of curing time, decreased with the increase of fiber length and F-T cycles, and stabilized after 6 ~ 10 cycles.. The optimal ratio was 0.2% fiber content, 12 mm fiber length and 14 days of curing. Moreover, AE characteristic parameters had a great correlation with the damage stages. The F-T damage could be divided into three stages by cumulative ring count and cumulative energy. The sudden change in AE amplitude symbolized the transformation of damage stage. The amplitude of 67 dB after 6 F-T cycles could be used as an early failure warning.
Evaluation of the performance of Fe 3 O 4 /MnO 2 hybrid nanozymes with doxorubicin on multicellular structure and their therapeutic management to limit the growth of human breast cancer cells
Authors: Sharifi Majid , Kamalabadi-Farahani Mohammad , Salmani Amir-Abas , Malaki Mahmoud 
Published: June 2024

Abstract

Overwhelming evidence suggests that nanozymes show great promise in cancer therapy due to their stable catalytic properties and cost-effectiveness. However, the diverse responses of nanozymes in therapy have presented challenges. After designing pH-sensitive Fe3O4/MnO2@DOX hybrid nanozymes with catalytic properties, we analyzed their characteristics using various techniques such as SEM, TEM, DLS, XRD, TGA, EDS, etc. We evaluated the nanozymes' toxicity on MCF-7 cells and their spheroids through MTT and flow cytometry assays, while also exploring their synergistic effects with photothermal therapy (PTT). The findings reveal that the 150–270 nm Fe3O4/MnO2@DOX hybrid nanozymes demonstrate stable DOX release and catalytic activity in generating O2 and °OH, effectively inhibiting the growth of MCF-7 cells. It was found that the effective concentration for MCF-7 cells had to be raised from 2.13 to 4.64 µg/mL to inhibit spheroid growth. Because of the toxicity of this concentration on normal cells, using synergistic approaches is crucial to minimize side effects. Also, the results of cytotoxicity mechanism in spheroids highlight the significant impact of PTT with Fe3O4/MnO2@DOX hybrid nanozymes in enhancing pro-inflammatory cytokines like TNF-α, CASP9, CASP7, and CASP3. Ultimately, optimizing the concentration of pH-sensitive hybrid nanozymes with PTT synergistic effects shows great potential for cancer treatment.
Design, Analysis and Comparison of Hybrid and Non-Pneumatic Tires
Authors: Ali Shamsher , Shah Syed Aliyar , Ahmad Moiz , Zain Syed Muhammad , Khan Ahsan Rehman 
Published: June 2024

Abstract

Tires are the only medium that moves a vehicle back and forth while also providing directional stability. This paper provides a comparative study that delves into the contrast between Non-Pneumatic Tires (NPT) and Hybrid Tires, analyzing their respective merits and demerits. Non- pneumatic tires (NPT) emerged as an alternative to traditional tube tires, aiming to mitigate issues such as tube bursts, maintenance, air pressure, and susceptibility to external factors. However, NPTs exhibit drawbacks including limited shock absorption, reduced ride comfort, and elevated costs. In response, Hybrid Tires emerge as a promising solution, offering a balance between the strengths of pneumatic and non-pneumatic designs while addressing the shortcomings of NPTs. By integrating pneumatic elements, Hybrid Tires enhance shock absorption, reduce weight, and improve ride comfort without compromising overall strength. This paper advocates for the superiority of Hybrid Tires over NPTs, presenting them as a viable alternative poised to advance the realm of tire technology toward greater efficiency, safety, and sustainability.
Primary Tubercular Osteomyelitis of Lateral Orbital Wall: A Rare Presentation
Authors: Sharma Vandana , gupta vikasdeep , kaur harmeet , raj anuradha 
Published: June 2024

Abstract

Osteomyelitis of facial bones is a very rare presentation. Primary presentation of tubercular osteomyelitis in facial bones is even rarer. We are reporting a case of zygomatic tubercular osteomyelitis presenting in a very innocuous way. Identification of such cases in early stage can help in timely intervention. A 30 years old female presented to Ophthalmology Out Patient Department (OPD) with complain of a mildly painful nodule over left lower eyelid, turning into an ulcer. After appropriate investigation, diagnosis of primary tubercular osteomyelitis of left zygomatic bone was made and patient underwent debridement and anti-tubercular treatment. Patient has healed satisfactorily, with no sinus formation, no residual bony on filtration and good cosmetic results. Early diagnosis and timely management of such cases can avoid extensive involvement of bone, thereby reducing the subsequent morbidity of the patients.
Characterization of exosome-mediated propagation of systemic inflammatory responses into the Central Nervous System
Authors: Kodali Mahesh Chandra , Salim Chinnu , Ismael Saifudeen , Lebovitz Sarah Grace , Lin Geng , Liao Francesca-fang 
Published: June 2024

Abstract

The mechanisms through which systemic inflammation exerts its effect on the CNS are still not completely understood. Exosomes are small (30 to 100 nanometers) membrane-bound extracellular vesicles released by most of the mammalian cells. Exosomes play a vital role in cell-to-cell communication. This includes regulation of inflammatory responses by shuttling mRNAs, miRNAs, and cytokines both locally and systemically to the neighboring as well as distant cells to further modulate their transcriptional and/or translational states and affect the functional phenotype of those cells that have taken up these exosomes. The role of circulating blood exosomes leading to neuroinflammation during systemic inflammatory conditions was further characterized. Serum-derived exosomes from LPS-challenged mice (SDEL) were freshly isolated from the sera of the mice that were earlier treated with LPS and used to study SDEL effects on neuroinflammation. Exosomes isolated from the sera of the mice injected with saline were used as a control. In-vitro studies showed that the SDEL upregulate pro-inflammatory cytokine gene expression in the murine cell lines of microglia (BV-2), astrocytes (C8-D1A), and cerebral microvascular endothelial cells (bEnd.3). To further study their effects in-vivo, SDEL were intravenously injected into normal adult mice. Elevated mRNA expression of pro-inflammatory cytokines was observed in the brains of SDEL recipient mice. Proteomic analysis of the SDEL confirmed the increased expression of inflammatory cytokines in them. Together, these results further demonstrate and strengthen the novel role of peripheral circulating exosomes in causing neuroinflammation during systemic inflammatory conditions.
Effects Of Different Frequencies Of Concurrent Training On Cardiometabolic Risk Factors In Young Adults With Overweight And Obesity: A Randomized Controlled Trial
Authors: Wu Yigao , Wang Jiacheng , Liu Ying , Li Youyou , Li Yixuan , zhang Yunqing , Yan Xu , Wu Min , Li Yanchun 
Published: June 2024

Abstract

BackgroundCardiometabolic risk factors are a significant health concern, particularly among young adults with overweight and obesity. Concurrent training, which combines aerobic and strength exercise, has been shown to improve cardiometabolic health. However, the effects of different training frequencies are not well understood.MethodForty-three participants (mean age: 19 years) were randomly assigned to either the CT-2 group (concurrent training twice per week, n = 22) or the CT-3 group (concurrent training three times per week, n = 21). The training regimen included 40 minutes of strength training followed by 40 minutes of aerobic exercises. Baseline and eight-week follow-up assessments included anthropometric measurements, body composition analysis, cardiovascular and metabolic parameters, VO2 max, and 1RM squat strength.ResultsBoth the CT-2 and CT-3 groups showed significant improvements in body mass, body fat percentage, fat mass, android fat mass, and gynoid fat mass (p < 0.01). However, the reduction in android/gynoid fat mass ratio was significant only in the CT-3 group (p < 0.05). Additionally, fasting glucose, fasting insulin, total cholesterol, triglycerides, HDL-C, LDL-C, TC/HDL-C, HOMA-IR, HOMA-IS, and HOMA-β levels decreased significantly in both groups post-intervention (p < 0.01). Increases in VO2 max (CT-2: p < 0.05; CT-3: p < 0.01) and 1RM squat strength (CT-2: p < 0.01; CT-3: p < 0.05) were also observed. Comparing the two groups, CT-3 group demonstrated more significant improvements in HDL-C (p < 0.05) and HOMA-IS (p < 0.05).ConclusionThese findings highlight the effectiveness of concurrent training in improving cardiometabolic risk factors in young adults with overweight and obesity. Both twice-weekly and three times-weekly training significantly improved these risk factors, with higher frequency training providing additional benefits.
Eccentric exercise-induced delayed onset trunk muscle soreness alters high-density surface EMG- torque relationships and lumbar kinematics
Authors: Arvanitidis Michail , Jiménez-Grande David , Haouidji-Javaux Nadège , Falla Deborah , Martinez-Valdes Eduardo 
Published: June 2024

Abstract

We aimed to assess high-density surface electromyography (HDsEMG)-torque relationships in the presence of delayed onset trunk muscle soreness (DOMS) and the effect of these relationships on torque steadiness (TS) and lumbar movement during concentric/eccentric submaximal trunk extension contractions. Twenty healthy individuals attended three laboratory sessions (24 hours apart). HDsEMG signals were recorded unilaterally from the thoracolumbar erector spinae with two 64-electrode grids. HDsEMG-torque signal relationships were explored via coherence (0-5Hz) and cross-correlation analyses. Principal component analysis was used for HDsEMG-data dimensionality reduction and improvement of HDsEMG-torque-based estimations. DOMS did not reduce either concentric or eccentric trunk extensor muscle strength. However, in the presence of DOMS, improved TS, alongside an altered HDsEMG-torque relationship and kinematic changes were observed, in a contraction-dependent manner. For eccentric trunk extension, improved TS was observed, with greater lumbar flexion movement and a reduction in δ-band HDsEMG-torque coherence and cross-correlation. For concentric trunk extensions, TS improvements were observed alongside reduced thoracolumbar sagittal movement. DOMS does not seem to impair the ability to control trunk muscle force, however, perceived soreness induced changes in lumbar movement and muscle recruitment strategies, which could alter motor performance if the exposure to pain is maintained in the long term.