bluuebunny/crossref_metadata_2025_split huggingface dataset:
Benign Paroxysmal Positional Vertigo Is Not a Prognostic Factor in Sudden Sensorineural Hearing Loss
Authors: Kim Young Hyo , Kim Kyu‐Sung , Choi Hoseok , Choi Jeong‐Seok , Han Chang Dok 
Published: December 2011

ObjectiveLittle is known concerning the role of benign paroxysmal positional vertigo (BPPV) as a prognostic factor for sudden sensorineural hearing loss (SSNHL). The purpose of this study is to analyze the hearing recovery in patients who have SSNHL with BPPV compared with those who have SSNHL without BPPV. The study also documented the relative incidence of each semicircular canal involvement.Study DesignCase‐control study.SettingAcademic tertiary otologic practice.Subjects and MethodsNinety patients diagnosed with SSNHL with vertigo were enrolled. Clinical characteristics such as gender, age, and pure tone audiogram threshold were compared between group A (SSNHL with BPPV, n = 17) and group B (SSNHL without BPPV, n = 73). The frequency of each canal involvement was compared between group A and another 111 patients with BPPV only (group C). The proportion of patients with hearing recovery was compared between patients with or without BPPV, and between those with or without canal paresis.ResultsPatients in group A did not display significant differences in the sex ratio, mean age, or initial results of pure tone audiogram threshold compared with those in group B. Most patients with SSNHL with BPPV had lateral canal canalithiasis (64.7%). The presence of BPPV had no influence on the recovery of hearing.ConclusionsThe clinical characteristics of patients with SSNHL with BPPV were not different from those with SSNHL without BPPV. The lateral canal was the most frequently involved, and the presence or absence of BPPV had no dramatic impact on the outcome of SSNHL.
Women’s Leadership Development in Higher Education
Authors: Madsen Susan R. , Longman Karen A. , Daniels Jessica R. 
Published: December 2011

The Problem. The intentional preparation of future leaders for higher education remains a critical need today in institutions across the globe. Many colleges and universities are now seeking to design programs that develop the leadership skills of faculty, staff, and administrators, and because of the shortage of women in leadership positions, special efforts need to focus on the development of women. Yet guidance and assistance are required to do so effectively and efficiently. The Solution. The purpose of this final article is to highlight a few of the particularly important findings across all articles in this Special Issue, offer some overall implications for leadership development and the HRD field, and provide tables of sample leadership programs for women in higher education at the national, state, and institutional levels. The Stakeholders. This article provides researchers and practitioners in various fields of study with implications toward more effectively developing, evaluating, researching, and implementing leadership programs for women in higher education.
Lessons learned from an osteoporosis clinical trial in frail long-term care residents
Authors: Greenspan SL , Nace D , Perera S , Ferchak M , Fiorito G , Medich D , Zukowski K , Adams D , Lee C , Saul M , Resnick NM 
Published: December 2011

Background Although osteoporosis affects women of all ages, the impact is most pronounced in frail residents in long-term care. Nevertheless, few interventional trials have been performed in this population, and few data on therapeutic alternatives are available in this cohort. Purpose We describe the challenges and lessons learned in developing and carrying out a trial in frail long-term-care residents. Methods The Zoledronic acid in frail Elders to STrengthen bone (ZEST) study was designed to examine the safety and efficacy of a single-dose therapy for osteoporosis in frail residents in long-term care in the Pittsburgh area. Women with osteoporosis who were 65 years of age and older and currently not on therapy were randomized in a blinded fashion to intravenous zoledronic acid or placebo. Follow-up of each participant was planned for 2 years. All participants received appropriate calcium and vitamin D supplementation. Results Seven hundred and thirty-three contacts were made with long-term care residents of nine participating facilities. Of 252 women screened, 181 were eligible, enrolled, and randomized. Multiple barriers to research in long-term-care facilities were encountered but overcome with direct communication, information sessions, in-service trainings, and social events. Lessons learned included designing the study in a manner that avoided placing an additional burden on an already overcommitted facility staff, a two-stage consent process to separate screening from randomization, and a flexible examination schedule to accommodate residents while obtaining the necessary outcome measurements. Furthermore, a mobile unit accessible to participants containing state-of-the-art dual x-ray absorptiometry (DXA), assessment for vertebral fractures, and phlebotomy equipment allows all assessments to be performed on-site at each facility. Serious adverse events are collected from affiliated hospitals in real time with a novel electronic surveillance system. Limitations The major limitation is selection of outcomes that can be assessed at participating facilities and do not require transport of participants to hospitals or clinics. Conclusions Clinical research for osteoporosis can be successfully and safely performed with frail residents in long-term care facilities. Lessons learned from this study may inform future investigations among frail elderly residents of these facilities.
Identification and analysis of phosphorylation status of proteins in dormant terminal buds of poplar
Authors: Liu Chang-Cai , Liu Chang-Fu , Wang Hong-Xia , Shen Zhi-Ying , Yang Chuan-Ping , Wei Zhi-Gang 
Published: December 2011

AbstractBackgroundAlthough there has been considerable progress made towards understanding the molecular mechanisms of bud dormancy, the roles of protein phosphorylation in the process of dormancy regulation in woody plants remain unclear.ResultsWe used mass spectrometry combined with TiO2phosphopeptide-enrichment strategies to investigate the phosphoproteome of dormant terminal buds (DTBs) in poplar (Populus simonii × P. nigra). There were 161 unique phosphorylated sites in 161 phosphopeptides from 151 proteins; 141 proteins have orthologs inArabidopsis, and 10 proteins are unique to poplar. Only 34 sites in proteins in poplar did not match well with the equivalent phosphorylation sites of their orthologs inArabidopsis, indicating that regulatory mechanisms are well conserved between poplar andArabidopsis. Further functional classifications showed that most of these phosphoproteins were involved in binding and catalytic activity. Extraction of the phosphorylation motif using Motif-X indicated that proline-directed kinases are a major kinase group involved in protein phosphorylation in dormant poplar tissues.ConclusionsThis study provides evidence about the significance of protein phosphorylation during dormancy, and will be useful for similar studies on other woody plants.
The dynamic system of parental work of care for children with special health care needs: A conceptual model to guide quality improvement efforts
Authors: Hexem Kari R , Bosk Abigail M , Feudtner Chris 
Published: December 2011

AbstractBackgroundThe work of care for parents of children with complex special health care needs may be increasing, while excessive work demands may erode the quality of care. We sought to summarize knowledge and develop a general conceptual model of the work of care.MethodsSystematic review of peer-reviewed journal articles that focused on parents of children with special health care needs and addressed factors related to the physical and emotional work of providing care for these children. From the large pool of eligible articles, we selected articles in a randomized sequence, using qualitative techniques to identify the conceptual components of the work of care and their relationship to the family system.ResultsThe work of care for a child with special health care needs occurs within a dynamic system that comprises 5 core components: (1) performance oftaskssuch as monitoring symptoms or administering treatments, (2) the occurrence of variouseventsand the pursuit ofvalued outcomesregarding the child's physical health, the parent's mental health, or other attributes of the child or family, (3) operating with availableresourcesand within certainconstraints(4) over the passage oftime, (5) while mentally representing ordepictingthe ever-changing situation anddetectingpossible problems and opportunities. These components interact, some with simple cause-effect relationships and others with more complex interdependencies.ConclusionsThe work of care affecting the health of children with special health care needs and their families can best be understood, studied, and managed as a multilevel complex system.
Molecular features of the complementarity determining region 3 motif of the T cell population and subsets in the blood of patients with chronic severe hepatitis B
Authors: Yang Jiezuan , He Jianqin , Lu Haifeng , Wei Li , Li Sujun , Wang Baohong , Diao Hongyan , Li Lanjuan 
Published: December 2011

Abstract

Background
T cell receptor (TCR) reflects the status and function of T cells. We previously developed a gene melting spectral pattern (GMSP) assay, which rapidly detects clonal expansion of the T cell receptor β variable gene (TCRBV) in patients with HBV by using quantitative real-time reverse transcription PCR (qRT-PCR) with DNA melting curve analysis. However, the molecular profiles of TCRBV in peripheral blood mononuclear cells (PBMCs) and CD8+, CD8- cell subsets from chronic severe hepatitis B (CSHB) patients have not been well described.

Methods
Human PBMCs were separated and sorted into CD8+ and CD8- cell subsets using density gradient centrifugation and magnetic activated cell sorting (MACS). The molecular features of the TCRBV CDR3 motif were determined using GMSP analysis; the TCRBV families were cloned and sequenced when the GMSP profile showed a single-peak, indicative of a monoclonal population.

Results
The number of skewed TCRBV in the CD8+ cell subset was significantly higher than that of the CD8- cell subset as assessed by GMSP analysis. The TCRBV11 and BV7 were expressed more frequently than other members of TCRBV family in PBMCs and CD8+, CD8- subsets. Also the relatively conserved amino acid motifs were detected in the TCRBV22, BV18 and BV11 CDR3 in PBMCs among patients with CSHB.

Conclusions
The molecular features of the TCRBV CDR3 were markedly different among PBMCs and CD8+, CD8- cell subsets derived from CSHB patients. Analysis of the TCRBV expression in the CD8+ subset was more accurate in assessing the status and function of circulating T cells. The expression of TCRBV11, BV7 and the relatively conserved CDR3 amino acid motifs could also help to predict and treat patients with CSHB.
Spinal cord stimulators and radiotherapy: First case report and practice guidelines
Authors: Walsh Lorraine , Guha Daipayan , Purdie Thomas G , Bedard Philippe , Easson Alexandra , Liu Fei-Fei , Hodaie Mojgan 
Published: December 2011

Abstract
Spinal cord stimulators (SCS) are a well-recognised treatment modality in the management of a number of chronic neuropathic pain conditions, particularly failed back syndrome and radiculopathies. The implantable pulse generator (IPG) component of the SCS is designed and operates in a similar fashion to that of a cardiac pacemaker. The IPG consists of an electrical generator, lithium battery, transmitter/receiver and a minicomputer. When stimulated, it generates pulsed electrical signals which stimulate the dorsal columns of the spinal cord, thus alleviating pain. Analogous to a cardiac pacemaker, it can be potentially damaged by ionising radiation from a linear accelerator, in patients undergoing radiotherapy. Herein we report our clinical management of the first reported case of a patient requiring adjuvant breast radiotherapy who had a SCS in situ. We also provide useful practical recommendations on the management of this scenario within a radiation oncology department.
Evaluation of rectus extraocular muscles using dynamic contrast-enhanced MR imaging in patients with Graves' ophthalmopathy for assessment of disease activity
Authors: Jiang Hong , Wang Zhenchang , Xian Junfang , Li Jing , Chen Qinghua , Ai Likun 
Published: December 2011

Background It is important to assess the activity of Graves' ophthalmopathy (GO) for planning optimal treatment strategy. Dynamic contrast-enhanced MR imaging (DCE-MRI) is a technique for assessment of microcirculation status. The correlation between disease activity and the microcirculation characteristics of extraocular muscles (EOMs) has been demonstrated in GO. Purpose To investigate the changes of rectus EOMs in patients with active vs. inactive GO using DCE-MRI, and to evaluate the value of DCE-MRI in assessing the activity of GO. Material and Methods Rectus EOMs of 20 healthy controls, 18 patients with active GO, and 16 patients with inactive GO were studied. The signal intensity (SI) of rectus EOMs on T2W images was evaluated. Regions of interest were placed on each rectus on DCE-MRI images. The DCE-MRI parameters including time to peak enhancement (Tpeak), enhancement ratio (ER), and wash-out ratio (WR) were calculated. Results There were significant differences in SI and Tpeak, ER and WR values among the three groups ( P = 0.000). However, there was no significant difference in SI between the active and inactive groups ( P = 0.07). Tpeak values of each rectus were significantly increased in inactive group compared with the active group ( P < 0.05). ER and WR values of the inferior rectus and WR values of the superior rectus in inactive group were significantly lower than those in active group ( P < 0.05). There was significant correlation between clinical activity score (CAS) and minimum Tpeak (minTpeak), maximum ER (maxER) and maximum WR (maxWR) ( P < 0.001). The cut-off values of minTpeak, maxER and maxWR were 156.98s, 1.31 and 13.50% respectively, giving positive predictive values of 68.00%, 88.90%, and 94.44% for the assessment of disease activity. Conclusion DCE-MRI could demonstrate the microcirculatory changes of rectus EOMs in both active and inactive GO, and this MRI method is a useful tool in differentiating active from inactive GO.
Fusion imaging technology of the intracranial veins
Authors: Zamboni P , Menegatti E , Viselner G , Morovic S , Bastianello S 
Published: December 2011

Objectives Fusion imaging technology (FIT) combines different imaging techniques by means of properly designed software. The aim of this study was to validate the ultrasonographic representation of intracranial vein anatomy by combining transcranial echo-colour Doppler (TECD) with conventional magnetic resonance imaging (MRI). In addition, we investigated the possibility of insonating the veins of the base of the skull through the novel condylar window. Methods We examined venous brain circulation in five healthy subjects by means of FIT, using a 1.5 T MR scanner and an ultrasound TECD equipped with Virtual Navigator technology. Results and conclusions Insonation of the Rosenthal and other intracranial veins through the classical transtemporal window, based on anatomical assumption, but never before validated by means of FIT study, was confirmed. Moreover, in all five subjects, FIT demonstrated the possibility of insonating the petrosal sinuses and the cavernous sinus area through the novel transcondylar approach. In conclusion, the feasibility of FIT of the intracranial veins potentially permits to study subjects in different postures and/or at the bed of non-transportable patients, after the initial MRI acquisition. Finally, the novel transcondylar approach allows obtaining haemodynamic information from the cavernous and the petrosal sinuses usually not investigated by TECD alone.
What advantage is there to be gained using large modular metal-on-metal bearings in routine primary hip replacement?
Authors: Malviya A. , Ramaskandhan J. R. , Bowman R. , Hashmi M. , Holland J. P. , Kometa S. , Lingard E. 
Published: December 2011

The aim of this study was to investigate the possible benefit of large-head metal-on-metal bearing on a stem for primary hip replacement compared with a 28 mm diameter conventional metal-on-polyethylene bearing in a prospective randomised controlled trial. We investigated cemented stem behaviour between these two different bearings using Einzel-Bild-Röntgen-Analyse, clinical and patient reported measures (Harris hip score, Western Ontario and McMaster Universities osteoarthritis index, Short Form-36 and satisfaction) and whole blood metal ion levels at two years. A power study indicated that 50 hips were needed in each group to detect subsidence of > 5 mm at two years with a p-value of < 0.05.Significant improvement (p < 0.001) was found in the mean clinical and patient reported outcomes at two years for both groups. Comparison of outcomes between the groups at two years showed no statistically significant difference for mean stem migration, clinical and patient reported outcomes; except overall patient satisfaction which was higher for metal-on-metal group (p = 0.05). Metal ion levels were raised above the Medicines and Healthcare products Regulatory Agency advised safety level (7 µg per litre) in 20% of the metal-on-metal group and in one patient in metal-on-polyethylene group (who had a metal-on-metal implant on the contralateral side). Two patients in the metal-on-metal group were revised, one for pseudotumour and one for peri-prosthetic fracture.Use of large modular heads is associated with a risk of raised whole blood metal ion levels despite using a proven bearing from resurfacing. The head-neck junction or excess stem micromotion are possibly the weak links warranting further research.
Does the addition of cement improve the rate of local recurrence after curettage of giant cell tumours in bone?
Authors: Gaston C. L. , Bhumbra R. , Watanuki M. , Abudu A. T. , Carter S. R. , Jeys L. M. , Tillman R. M. , Grimer R. J. 
Published: December 2011

We retrospectively compared the outcome after the treatment of giant cell tumours of bone either with curettage alone or with adjuvant cementation. Between 1975 and 2008, 330 patients with a giant cell tumour were treated primarily by intralesional curettage, with 84 (25%) receiving adjuvant bone cement in the cavity. The local recurrence rate for curettage alone was 29.7% (73 of 246) compared with 14.3% (12 of 84) for curettage and cementation (p = 0.001). On multivariate analysis both the stage of disease and use of cement were independent significant factors associated with local recurrence. The use of cement was associated with a higher risk of the subsequent need for joint replacement. In patients without local recurrence, 18.1% (13 of 72) of those with cement needed a subsequent joint replacement compared to 2.3% (4 of 173) of those without cement (p = 0.001). In patients who developed local recurrence, 75.0% (9 of 12) of those with previous cementation required a joint replacement, compared with 45.2% (33 of 73) of those without cement (p = 0.044).
Intolerance of Uncertainty and Meta-Worry: Relative Importance in Discriminating GAD
Authors: Khawaja Nigar G. , McMahon Janette , Strodl Esben 
Published: December 2011

AbstractThis study explored whether intolerance of uncertainty and/or meta-worry discriminate between non-clinical individuals and those diagnosed with generalised anxiety disorder (GAD group). The participants were 107 GAD clients and 91 university students. The students were divided into two groups (high and low GAD symptom groups). A multivariate analysis of covariance (MANCOVA) adjusting for age indicated that intolerance of uncertainty distinguished between the low GAD symptom group and the high GAD symptom group, and between the low GAD symptom group and the GAD group. Meta-worry distinguished all three groups. A discriminant function including intolerance of uncertainty and meta-worry classified 94.4% of the GAD group and 97.9% of the low GAD symptom group. Only 6.8% of the high GAD symptom group was classified correctly, 77.3% of the high GAD symptom group was classified as GAD. Findings indicated that intolerance of uncertainty and meta-worry may assist with the diagnosis and treatment of GAD.
A Pilot Trial of Proactive Versus Reactive Referral to Tobacco Quitlines
Authors: Stoltzfus Ky , Ellerbeck Edward F. , Hunt Suzanne , Rabius Vance , Carlini Beatriz , Ayers Candace , Richter Kimber P. 
Published: December 2011

AbstractOverview:Many U.S. hospitals use fax-referral to quitlines to provide outpatient follow-up. It is important to understand whether it is better to refer all smokers, or only those ready to quit, to quitline services. The purpose of this pilot project was to evaluate the feasibility and intermediate out-comes of a proactive (offering fax referral to all smokers) versus a reactive (pre-screening for readiness to quit within the next 30 days) approach to quitline fax-referral.Method:We employed a pre-test, post-test comparison group design in which a script-based reactive approach was employed over a two-week period and a script-based proactive approach was employed in the following two-week period. Scripts were inserted into the counselling protocols of a pre-existing inpatient treatment program.Major Findings:We enrolled 45 patients — 25 during the reactive, and 20 during the proactive block. In the reactive group, 12 (48%) indicated that they were ready to quit smoking and accepted fax-referral to the quitline. Nine (75%) were successfully contacted and enrolled in the quitline, for an overall quitline enrolment rate of 36% (9/25). In the proactive group, all accepted fax-referral to the quitline and 11 were successfully contacted and enrolled by the quitline for an overall enrolment rate of 55% (11/20). Quitlines were able to reach and enrol a higher proportion of patients referred to them, when patients were pre-screened for readiness to quit. Offering quitline referral, regardless of readiness to quit, potentially expands the reach and possibly the impact of quitline counselling.
Novel Error Prediction Method of Dynamic Measurement Lacking Information
Authors: Leyi Ge , Wei Zhao , Songling Huang , Jing Zhou 
Published: December 2011

Abstract
Predicting for dynamic measurement error is becoming a hot issue in measurement field. The paper deals with the error prediction of dynamic measurement lacking information. Firstly, according to grey system theory and the bootstrap method, the prediction and transfer coefficients of all error sources have been taken into account. Then, the error prediction of dynamic measurement lacking information, are obtained starting from each error sources’ absolute accuracy in terms of the error combination principle. Finally, in a general dynamic measurement, the predicting measurement errors obtained by means of this novel proposed method are compared with the ones obtained from Monte Carlo method. The results are in good agreement with each other.
Mimikry und jüdische Identität(en) in der zeitgenössischen polnisch- und russisch-jüdischen Literatur
Authors: Smola Klavdia 
Published: December 2011

Abstract
This article considers the phenomenon of mimicry as dealt with in contemporary Polish-Jewish and Russian-Jewish literature. Due to the massive social, religious and political marginalisation of Jews in the 20th century, mimicry once again became widespread among Eastern European Jews over this period as a special means of ethnic and cultural assimilation, dissimulation and deception. The effects of mimicry on the identity of Jews, often long after the end of the Holocaust, or more recently the fall of the communist dictatorships, are reflected in texts by Eastern European Jewish authors. The article considers mimicry as a complex-laden strategy that gives contemporary relevance once again to the problems of the socially constructed “Jewish body”, and ancient historical phenomena such as European crypto-Judaism.