bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gamma‐glutamyltransferase, cardiovascular disease and mortality in individuals with diabetes mellitus
Authors: Sluik Diewertje , Beulens Joline W.J. , Weikert Cornelia , van Dieren Susan , Spijkerman Annemieke M.W. , van der A Daphne L. , Fritsche Andreas , Joost Hans‐Georg , Boeing Heiner , Nöthlings Ute 
Published: December 2011

AbstractBackgroundIncreased plasma activity of gamma‐glutamyltransferase (GGT) is associated with cardiovascular diseases (CVD) and mortality in the general population. We investigated the association between GGT, CVD and mortality in individuals with diabetes mellitus.MethodsData used were from 1280 participants, aged 35–70 years, with a confirmed diagnosis of diabetes mellitus in the European Prospective Investigation into Cancer and Nutrition in Potsdam (Germany), Bilthoven and Utrecht (the Netherlands). Multivariate hazard ratios (HR) and 95% confidence intervals (CI) for CVD (non‐fatal and fatal events) and overall mortality were estimated using sex‐specific quartiles of GGT.ResultsAfter 8.2 years follow‐up, 108 incident CVD cases and 84 deaths were observed. Participants with high GGT activity had an increased mortality risk: HR in the highest quartile was 3.96 (95% CI 1.74, 9.00). This association was in particular present in former and current smokers, younger persons and those with a higher waist–height ratio and alcohol consumption. No associations were observed for non‐fatal CVD and non‐fatal and fatal CVD events combined.ConclusionsHigher GGT plasma activity is associated with increased all‐cause mortality in individuals with diabetes. Copyright © 2011 John Wiley & Sons, Ltd.
Signaling and gene regulatory programs in plant vascular stem cells
Authors: Zhou Jing , Sebastian Jose , Lee Ji‐Young 
Published: December 2011

AbstractVascular systems in the woody stem of an apple tree. Xylem (in light brown) and phloem (in blue) arise from the cambium that resides between the two. Stem cells in the cambium actively divide in an asymmetric manner, and their daughters differentiate into xylem or phloem in response to the positional information.
Activation of Nitriles by Trichloro[2‐(dialkylphosphanyl)imidazol‐1‐yl]silanes – Synthesis and Characterization of New Dinuclear Pentacoordinate Silicon(IV) Complexes with Bridging Imido‐Nitrogen Ligand Atoms
Authors: Junold Konstantin , Burschka Christian , Tacke Reinhold 
Published: December 2011

AbstractTrichloro[2‐(dialkylphosphanyl)imidazol‐1‐yl]silanes 3 and 4 react with aceto‐ or propionitrile to yield the dinuclear pentacoordinate silicon(IV) complexes 5–8, which contain two bridging dianionic N,N‐ligands generated by silicon‐mediated nitrile activation. Compounds 5–8 contain two SiCl2N3 skeletons, with two imido‐nitrogen ligand atoms that bridge the silicon coordination centers. The pentacoordinate silicon(IV) complexes 5–8 were characterized by elemental analysis, single‐crystal X‐ray diffraction, and solid‐state NMR spectroscopy.
Zinc Complexes of Piperazinyl‐Derived Aminephenolate Ligands: Synthesis, Characterization and Ring–Opening Polymerization Activity (Eur. J. Inorg. Chem. 35/2011)
Authors: Ikpo Nduka , Saunders Lisa N. , Walsh Jillian L. , Smith Jennifer M. B. , Dawe Louise N. , Kerton Francesca M. 
Published: December 2011

AbstractThe cover picture shows a butterfly‐shaped dimetallic alkylzinc complex reported by researchers at Memorial University, which is shown in the background. The complex, reported in the article by F. M. Kerton et al. on p. 5347 ff, can be readily converted to an alkoxide species. This initiates ring‐opening polymerization of rac‐lactide and ϵ‐caprolactone under conventional heating or upon microwave irradiation. Financial support from the Publication Subvention Program of Memorial University of Newfoundland is acknowledged.magnified image
Molecular and Macromolecular Engineering with Viologens as Building Blocks: Rational Design of Phosphorus–Viologen Dendritic Structures
Authors: Katir Nadia , Majoral Jean Pierre , El Kadib Abdelkrim , Caminade Anne‐Marie , Bousmina Mostapha 
Published: December 2011

AbstractThe design of symmetric or asymmetric diversely functionalized monomer, dimer, or trimer viologens and the design of phosphorus building blocks allows the synthesis of unique types of mix phosphorus–viologen dendrimers. Strategies for the preparation of dendrimers of generations 0 and 1 are presented as are those for various dendrons. These methods exhibit broad applicability, high efficiency and usability, and are compatible with the presence of various functional groups (aldehyde, cyano, phenol, phosphonate, brominated groups).
(E)‐Dimethyl 2‐Oxopent‐3‐enylphosphonate: An Excellent Substrate for Cross‐Metathesis – Easy Access to Functionalized Heterocycles
Authors: Cochet Thomas , Roche Didier , Bellosta Véronique , Cossy Janine 
Published: December 2011

AbstractSimple and efficient access to tetrahydrofurans, tetrahydropyrans, and pyrrolidines through a tandem cross‐metathesis/1,4‐addition process from (E)‐dimethyl 2‐oxopent‐3‐enylphosphonate and N‐protected ω‐unsaturated amines or alcohols under microwave irradiation is described. As the Grubbs–Hoveyda catalyst is highly chemoselective, a diversity of functionalized heterocycles were synthesized. Furthermore, an additional functionalization can be performed due to the presence of a side chain that possesses a ketophosphonate at the C2 position of the heterocycle.
Communality sells: The impact of perceivers' sexism on the evaluation of women's portrayals in advertisements
Authors: Infanger Martina , Bosak Janine , Sczesny Sabine 
Published: December 2011

AbstractPortrayals of women in advertisements have a significant impact on the maintenance of gender stereotypes in society. Therefore, the present research investigates the effectiveness of communal and agentic female characters in advertisements as well as the question how evaluations of such characters are influenced by perceivers' sexist attitudes toward women. Results show that communal female advertising characters are evaluated more favorably than agentic ones and that these evaluations predict advertising effectiveness. Benevolent sexism predicts more positive evaluations of communal female advertising characters (studies 1 and 2). Moreover, hostile sexism predicts less positive evaluations of agentic female advertising characters when it is assessed under time pressure (Study 2). Implications of these findings for the perpetuation of gender stereotypes in advertisements and in society are discussed. Copyright © 2011 John Wiley & Sons, Ltd.
Rapid detection of dysfunctional high‐density lipoproteins using isoelectric focusing‐based microfluidic device to diagnose senescence‐related disease
Authors: Jang Wookju , Shim Jaesool , Lee Dong‐Yeon , Dutta Prashanta , Kim Jae‐Ryong , Cho Kyung‐Hyun 
Published: December 2011

AbstractRecently, we reported elevated levels of advanced glycated end products (AGEs) in human high‐density lipoproteins (HDL), with fragmentation of apoA‐I in an elderly group, compared with a younger group. More dysfunctional HDL from human plasma was demonstrated in the elderly group, including reconstituted HDL containing glycated apoA‐I (gA‐I‐rHDL) with elevation of AGEs. Based on SDS‐PAGE analysis, HDL3 from the elderly group (E‐HDL3) exhibited increased multimerization with increased smear band intensity compared to HDL3 from the younger group (Y‐HDL3). According to isoelectric focusing gel analysis, gA‐I‐rHDL and E‐HDL3 showed electromobility to the basic region of pH with a broader band range. In a microfluidic channel, E‐HDL3 had faster mobility with a broader range and a higher isoelectric point (pI, approximately 8.1), whereas Y‐HDL3 showed a narrow band range with a lower pI (approximately 6.9). In conclusion, gA‐I‐rHDL and E‐HDL share several electrophoretic properties with multimerization and faster mobility in microfluidic channels, depending on the isoelectric point. These results can be applied to develop a rapid detection system for modified HDL to predict the extent of aging and aging‐related metabolic diseases, such as cardiovascular disease and diabetes.
A publicly verifiable PCAE scheme for confidential applications with proxy delegation
Authors: Wu Tzong‐Sun , Lin Han‐Yu , Ting Pei‐Yih 
Published: December 2011

ABSTRACTWith the diversity of business transactions, new application requirements will emerge. Many confidential transactions, such as online auctions and bank savings withdrawals, sometimes might be conducted by an authorized proxy. In this paper, we propose a bilinear pairing‐based proxy convertible authenticated encryption scheme. The proposed scheme allows the delegated proxy signer to generate an authenticated ciphertext in behalf of the original signer while only the designated recipient is able to decrypt the ciphertext and verify the proxy signature. To benefit the encryption of a large message, we further present another variant with message linkages. Both schemes are publicly verifiable, that is, the designated recipient can convert the ciphertext into an ordinary proxy signature for public verification. In addition, the security requirement of confidentiality against indistinguishability under adaptive chosen‐ciphertext attacks and that of unforgeability against existential forgery under adaptive chosen‐message attacks are proved in random oracle models. Copyright © 2011 John Wiley & Sons, Ltd.
Occurrence of rare, crustose lichen, Ophioparma ventosa (Ophioparmaceae, lichenized Ascomycota), from alpine regions of Arunachal Pradesh, India
Authors: Khare Roshni , Rai Himanshu , Upreti Dalip Kumar , Dubey Urvashi , Gupta R. K. 
Published: December 2011

AbstractOphioparma ventosa (L.) Norman, belonging to family Ophioparmaceae, a rare lichen species has been recorded for the first time from north east alpine Himalaya, India after the gap of more than hundred years, when it was first recorded by Leighton from Sikkim in the year 1879. This saxicolous species is found growing together with other saxicolous lichens and mosses. This species was recorded previously from alpine regions of Eastern Nepal (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Metro Thessaloniki: Tiefe Baugruben in Deckelbauweise
Authors: Vassilakopoulou Georgia , Rizos Dimitris , Vrettos Christos 
Published: December 2011

AbstractDie neue U‐Bahn in Thessaloniki befindet sich seit 2006 im Bau. Mit einer Streckenlänge von 9, 6 km umfasst sie, neben dem Schildvortrieb zweier Röhren, die Errichtung von 13 Bahnhöfen mit zentralem Bahnsteig. Zur Reduzierung von Verkehrsstörungen und zur Begrenzung der Setzungen in der Nachbarschaft wurde eine Deckelbauweise mit Schlitzwänden gewählt. Wegen der engen Platzverhältnisse musste dabei auf eine Innenschale verzichtet werden. Weitere erschwerende Randbedingungen sind der weiche inhomogene Untergrund, die große Aushubtiefe im Grundwasser und die Seismizität am Standort. Beginnend mit der Projektbeschreibung werden für zwei typische Bahnhöfe die erdstatischen Nachweise und die Maßnahmen zur dauerhaften Auftriebssicherung zusammengefasst sowie gemessene und prognostizierte Systemverformungen gegenübergestellt.Thessaloniki Metro: Deep excavations by the top‐down method. The new Thessaloniki Metro has been under construction since 2006. The total length of 9.6 km includes, beside the excavation of two tunnels, the construction and support of deep excavations for 13 stations with central platforms. In order to reduce traffic disturbance and to minimize settlements in the neighbourhood, a top‐down construction method with diaphragm walls was adopted. Due to the limited space availability, stations were constructed without an inner lining. Further difficulties are associated with the soft inhomogeneous subsoil, the large excavation depths below the groundwater level and the seismicity at the site. Starting with a project description, the paper briefly presents the geotechnical design for two typical stations and the measures taken for providing safety against uplift. Measured and predicted system responses are also compared.
Use of a posterior pedicle nasal septum and floor mucoperiosteum flap to resurface the nasopharynx after endoscopic nasopharyngectomy for recurrent nasopharyngeal carcinoma
Authors: Chen Ming–Yuan , Wang Shun–Lan , Zhu Yu–Liang , Shen Guo–Ping , Qiu Fang , Luo Dong–Hua , Chen Qiu–Yan , Jiang Rou , Cao Ka–Jia , Qian Chao–Nan , Hong Ming–Huang 
Published: December 2011

AbstractBackgroundEndoscopic nasopharyngectomy is a new salvage treatment for locally recurrent nasopharyngeal carcinoma (NPC). However, how to resurface the nasopharyngeal defects in endoscopic endonasal approaches to avoid persistent postoperative headache, to the best of our knowledge, has not been reported.MethodsFrom September 2009 to August 2010, we used a modified posterior pedicle nasal septum and floor mucoperiosteum flap (nasal septum and floor flap, NSFF) after endoscopic nasopharyngectomy in 12 patients with locally recurrent NPC. Most of the nasal septum and floor mucoperiosteum, except for the posterior pedicle, was harvested to cover the nasopharyngeal defects.ResultsAll NSFFs successfully covered the entire nasopharyngeal defects and relined the nasopharynx with good functional recovery. The nasopharyngeal wounds recovered in 28 days (range, 14 to 56 days), and the donor‐site wounds recovered in 46.5 days (range, 24–84 days). No reconstruction‐related complications or disease recurrences were observed.ConclusionThe NSFF is a safe and promising reconstructive option to resurface the nasopharyngeal defect after endoscopic nasopharyngectomy in patients with locally recurrent NPC. © 2011 Wiley Periodicals, Inc. Head Neck, 2011
Experimental study of natural frost formation over a horizontal tube with annular compact fins under natural convection
Authors: Mahdavi Mostafa , Yaghoubi Mahmood 
Published: December 2011

AbstractThis paper presents experimental measurements of natural convection heat transfer and frost deposition over a horizontal fin‐tube. Measurements are made for a fin‐tube of diameter 25.4 mm, fin thickness 0.4 mm, fin center diameter 56 mm, and fin spacing 2 mm. For measurements the ambient air temperature and relative humidity are changed from 18 to 25°C and from 35% to 55%, respectively. The tube surface temperature is changed from –5 to –9 °C, and super cooling degrees of 7.5 to 24.5 °C. Results include a visualization of frost deposition growth, frost accumulation rate, and heat transfer rate with respect to time for each experiment. The results show that cold air starts from the upper point and moves downward and frost deposition starts on the fin tips, and grows with time both radially and angularly. Frost growth thickness changes significantly from top to bottom, where the boundary layers of both thermal and concentration increase at the bottom of the fin‐tube section without considerable separation. Frost growth only takes place on the fin's tip and it blocks the heat and mass transfer from the fin surfaces and the tube base which reduces convection and frost growth considerably. © 2011 Wiley Periodicals, Inc. Heat Trans Asian Res; Published online in Wiley Online Library (wileyonlinelibrary.com/journal/htj). DOI 10.1002/htj.20397
Predictive impact of MGMT promoter methylation in glioblastoma of the elderly
Authors: Reifenberger Guido , Hentschel Bettina , Felsberg Jörg , Schackert Gabriele , Simon Matthias , Schnell Oliver , Westphal Manfred , Wick Wolfgang , Pietsch Torsten , Loeffler Markus , Weller Michael ,   for the German Glioma Network
Published: December 2011

AbstractO6‐methylguanine‐DNA‐methyltransferase (MGMT) promoter methylation identifies a subpopulation of glioblastoma patients with more favorable prognosis and predicts a benefit from alkylating agent chemotherapy (CT). Little is known about its prevalence and clinical significance in older glioblastoma patients. We studied 233 glioblastoma patients aged 70 years or more (144 males, 89 females, median age: 74 years, range: 70.0–86.6 years), who were prospectively enrolled in the German Glioma Network, for MGMT promoter methylation by methylation‐specific PCR (MSP) in all patients and DNA pyrosequencing in 166 patients. MGMT data were correlated with patient outcome. Median progression‐free survival (PFS) was 4.8 months (95% CI: 4.3–5.3) and median overall survival (OS) was 7.7 months (95% CI: 6.3–9.0). MGMT promoter methylation was detected by MSP in 134 patients (57.5%). For the whole cohort, PFS was 5.2 versus 4.7 months (p = 0.207) and OS was 8.4 versus 6.4 months (p = 0.031) in patients with versus without MGMT promoter methylation. Patients with MGMT methylated tumors had longer PFS when treated with radiotherapy (RT) plus CT or CT alone compared to patients treated with RT alone. Patients with MGMT unmethylated tumors appeared to derive no survival benefit from CT, regardless of whether given at diagnosis together with RT or as a salvage treatment. Patients treated with RT plus CT or CT alone demonstrated longer OS when pyrosequencing revealed >25% MGMT methylated alleles. Taken together, MGMT promoter methylation may be a useful biomarker to stratify elderly glioblastoma patients for treatment with versus without alkylating agent CT.
SMILE silencing and PMA activation gene networks in hela cells: Comparison with kidney transplantation gene networks
Authors: Racapé M. , Bragazzi N. , Sivozhelezov V. , Danger R. , Pechkova E. , Duong Van Huyen J.P. , Soulillou J.P. , Brouard S. , Nicolini C. 
Published: December 2011

AbstractRecent findings indicated that the SMILE gene may be involved in kidney graft operational tolerance in human. This gene was found to be up‐regulated in blood from patients with a well functioning kidney transplant in the absence of immunosuppression compared to other transplanted recipients with clinically different status. A microarray study of SMILE knock‐down and phorbol 12‐myristate 13‐acetate (PMA) activation in HeLa cells was herein compared to our earlier analysis based on microarray data of kidney allograft tolerance and rejection in humans and in a rat model of allograft transplantation to determine possible new genes and gene networks involved in kidney transplantation. The nearest neighbors at the intersection of the SMILE knock‐down network with the human tolerance/rejection networks are shown to be NPHS1 and ARRB2, the former (Nephrin) being involved in kidney podocyte function, and the decrease of the latter (Arrestin β2) being recently shown to be involved in monocyte activation during acute kidney allograft rejection in rat. Moreover, another one of the neighbors at the intersection of SMILE network and tolerance/rejection networks is XBP‐1, that we report previously to be increased, at a transcript level, after ER stress in SMILE silenced cells. Finally, in this study, we also show that topological properties (both local and global) of joint SMILE knock‐down network—tolerance/rejection networks and joint PMA activation network—tolerance/rejection networks in rat and human are essentially different, likely due to the inherent nature of the gene SMILE and the mitogen PMA, that do not act the same way on genes and do not interfere the same way on networks. We also show that interestingly SMILE networks contain more feed‐forward loop (FFL) motifs and thus SMILE calls for a more fine‐tuned genetic regulation. J. Cell. Biochem. 113: 1820–1832, 2012. © 2011 Wiley Periodicals, Inc.
Amperometric biosensor for nitrite and hydrogen peroxide based on hemoglobin immobilized on gold nanoparticles/polythionine/platinum nanoparticles modified glassy carbon electrode
Authors: Zhang Yu , Yuan Ruo , Chai Yaqin , Wang Jinfen , Zhong Huaan 
Published: December 2011

AbstractBACKGROUND: This paper describes a convenient and effective strategy to construct a highly sensitive amperometric biosensor for nitrite (NO2−) and hydrogen peroxide (H2O2). First, Pt nanoparticles (PtNPs) were electrodeposited on a glassy carbon electrode (GCE) surface, which promoted electron transfer and enhanced the loading of poly‐thionine (PTH). Subsequently, thionine (TH) was electropolymerized on the PtNPs/GCE, and gold nanoparticles (AuNPs) were assembled onto the PTH film to improve the absorption capacity of hemoglobin (Hb) and further facilitate electron transfer. Finally, Hb was immobilized onto the electrode through the AuNPs.RESULTS: Cyclic voltammetry (CV) and scanning electron microscopy (SEM) were used to characterize the fabrication process of the sensing surface. Under optimum conditions, the biosensors can be used for the determination of NO2− in the concentration range 70 nmol L−1 to 1.2 mmo L−1 and of H2O2 in the range 4.9 µmol L−1 to 6.8 mmol L−1. The detection limits (S/N = 3) were 20 nmol L−1 and 1.4 µmol L−1, respectively.CONCLUSION: The biosensor exhibits good analytical performance, acceptable stability and good selectivity. Copyright © 2011 Society of Chemical Industry
Comparison of dispersive liquid–liquid microextraction based on organic solvent and ionic liquid combined with high‐performance liquid chromatography for the analysis of emodin and its metabolites in urine samples
Authors: Tian Jie , Chen Xuan , Bai Xiaohong 
Published: December 2011

AbstractIn this paper, two methods based on organic solvent dispersive liquid–liquid microextraction (OS‐DLLME) and ionic liquid dispersive liquid–liquid microextraction (IL‐DLLME) coupled with high‐performance liquid chromatography have been critically compared for analyzing emodin and its metabolites (aloe‐emodin, anthraquinone‐2‐carboxylic acid, rhein, danthron, chrysophanol and physcion) in urine samples. Several important parameters influencing the extraction recoveries of DLLME were carefully optimized. Under optimal conditions, the enrichment factors (EFs) for emodin and its metabolites by OS‐DLLME and IL‐DLLME were within the range of 90–295 and 63–192 respectively; the relative standard deviations (RSDs, n=3) for intra‐day and inter‐day precision were lower than 7.2 and 8.7% by OS‐DLLME, and lower than 5.7 and 6.4% by IL‐DLLME; the recoveries of emodin and its metabolites were from 87.1 to 105% for OS‐DLLME and from 94.8 to 103% for IL‐DLLME, respectively. There were no significant deviations between the two methods for the determination of emodin and its metabolites. From the results of HPLC/UV of urine sample after DLLME, the metabolites aloe‐emodin, rhein, chrysophanol and physcion were identified by comparing the retention times with the standards. From the results of HPLC/MS, anthraquinone‐2‐carboxylic acid and danthron as unreported metabolites of emodin were found.
The psychological impact of deployment on OEF/OIF healthcare providers
Authors: Hickling Edward J. , Gibbons Susanne , Barnett Scott D. , Watts Dorraine 
Published: December 2011

AbstractThe psychological impact of military experience on healthcare providers has received little attention to date. The 2005 Department of Defense Survey of Health Related Behaviors Among Active Duty Personnel was used as a secondary data source, and deployed healthcare officers and healthcare specialists were identified and compared to deployed non‐healthcare officers and enlisted personnel: 6,116 respondents were surveyed. Findings revealed clinically significant psychological distress among deployed military healthcare provider respondents including posttraumatic stress symptoms, depression, anxiety, and adverse psychosocial impact, more prominent in the deployed healthcare specialist group. Based upon findings, possible factors for resilience and increased risk, as well as potential intervention needs in this healthcare provider group of service members are offered. Implications for future prospective studies are suggested.