bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early-stage health technology assessment of fractional flow reserve coronary computed tomography versus standard diagnostics in patients with stable chest pain in The Netherlands
Authors: Boot Iris W. A. , Planken R. Nils , den Hartog Alexander W. , Vrijhoef Hubertus J. M. 
Published: June 2024

Objectives
The aim of this early-stage Health Technology Assessment (HTA) was to assess the difference in healthcare costs and effects of fractional flow reserve derived from coronary computed tomography (FFRct) compared to standard diagnostics in patients with stable chest pain in The Netherlands.

Methods
A decision-tree model was developed to assess the difference in total costs from the hospital perspective, probability of correct diagnoses, and risk of major adverse cardiovascular events at one year follow-up. One-way sensitivity analyses were conducted to determine the main drivers of the cost difference between the strategies. A threshold analysis on the added price of FFRct analysis (computational analysis only) was conducted.

Results
The mean one-year costs were €2,680 per patient for FFRct and €2,915 per patient for standard diagnostics. The one-year probability of correct diagnoses was 0.78 and 0.61, and the probability of major adverse cardiovascular events was 1.92x10-5 and 0.01, respectively. The probability and costs of revascularization and the specificity of coronary computed tomography angiography had the greatest effect on the difference in costs between the strategies. The added price of FFRct analysis should be below €935 per patient to be considered the least costly option.

Conclusions
The early-stage HTA findings suggest that FFRct may reduce total healthcare spending, probability of incorrect diagnoses, and major adverse cardiovascular events compared to current diagnostics for patients with stable chest pain in the Dutch healthcare setting over one year. Future cost-effectiveness studies should determine a value-based pricing for FFRct and quantify the economic value of the anticipated therapeutic impact.
The View from Somewhere: Undoing the Myth of Journalistic Objectivity, Lewis Raven Wallace (2019)
Authors: Mason Bonita 
Published: June 2024

Review of: The View from Somewhere: Undoing the Myth of Journalistic Objectivity, Lewis Raven Wallace (2019)
ISBN 978-0-22682-658-5, p/bk, USD 18 (AUD 28.40)
ISBN 978-0-22666-743-0, e-book, USD 17.99 (AUD 28.40)
Nurturing Social Skills in Adolescents: Patterns of Development in Lembaga Kesejahteraan Sosial Anak (LKSA) Muhammadiyah Kota Bandung
Authors: Hassa Yanura Khairina  , Yoyoh Jubaedah  , Nenden Rani Rinekasari  
Published: June 2024

Enhancing social skills in adolescents facing complex challenges, such as those residing in orphanages, follows a distinct trajectory compared to their counterparts living with families. This research endeavors to uncover the nuanced patterns of adolescent social skill development within the Muhammadiyah Child Welfare Institution (LKSA) in Bandung City. Employing a qualitative methodology with an intervention theory approach in casework, this study seeks to identify strategies for improving social skills. The results indicate that the enhancement of social skills among adolescents in LKSA Muhammadiyah Bandung City is achieved by addressing aspects of peer relations, self-management, and compliance. This is facilitated through increased adolescent participation, the cultivation of emotional intelligence, and the promotion of productive self-management. These interventions contribute to heightened self-identity and independence in social activities among adolescents. The cultivation of self-reliance becomes integral to improving adolescents' societal functioning, leading to an augmentation in social community acceptance. This positive transformation stems from bolstering the mental and physical readiness of adolescents through affective and psychomotor strengthening.
Keywords: Caregiver, Social Skills, Early Adolescents

Peningkatan keterampilan sosial pada remaja yang memiliki kompleksitas problem, seperti remaja yang berada di panti asuhan memiliki pola berbeda dengan remaja yang hidup bersama keluarganya. Penelitian ini bertujuan untuk mengidentifikasi pola peningkatan keterampilan sosial remaja di Lembaga Kesejateraan Anak (LKSA) Muhammadiyah di Kota Bandung. Penelitian ini menggunakan metode kualitatif dengan pendekatan teori intervensi dalam casework. Hasil penelitian menunjukkan bahwa peningkatan kemampuan sosial pada remaja di LKSA Muhammadiyah Kota Bandung dicapai dengan peningkatan pada aspek peer relation skills, self-management skill, and compliance skill melalui peningkatan partisipasi remaja, pembangunan intelegensi emosional, dan pengelolaan diri secara produktif. Tiga aspek yang dilakukan mengarah pada peningkatan identitas diri dan kemandiran remaja dalam aktivitas sosialnya. Penanaman terhadap kemandirian diri merupakan bagian dari peningkatan keberfungsian remaja dalam masyarakat agar aspek penerimaan komunitas sosialnya semakin meningkat. Peningkatan tersebut dihasilkan dari penanaman kesiapan mental dan fisik remaja melalui penguatan afektif dan psikomotorik.
Kata Kunci: Pengasuh, Keterampilan Sosial, Remaja Awal
Empowering the Community or Corporate Image Building?: Analysis of Rengganis Agro Tourism (WAR) in Gunung Gambir Area by PT. Perkebunan Nusantara (PTPN) XII
Authors: Febriyanti Maya Putri , Hendrijanto Kris , Poerwanti Sari Dewi 
Published: June 2024

PT. Perkebunan Nusantara (PTPN) XII, as part of its corporate social responsibility, aims to enhance economic activity in the Mount Gambir area through Agro Rengganis Tourism (WAR), with the primary goal of fostering image development through empowerment. This qualitative study seeks to identify the various motives underlying empowerment initiatives in the Mount Gambir region, employing the theory of legitimacy as its perspective. The research reveals that PTPN XII employs an independence model in its empowerment process, focusing on improving community welfare via Rengganis Agro Tourism. This model involves providing the community with the autonomy to identify and harness the potential of their natural surroundings. PTPN serves as a facilitator, offering necessary developmental support such as training and education. This approach proves effective in elevating the standard of living for the local population. However, the study highlights a notable gap in the sustainability aspect of the empowerment process. The current program tends to prioritize image-building and maintaining positive relations between PTPN XII and the community, potentially overlooking long-term sustainability efforts.

Keywords: Community empowerment, agrotourism, social welfare

Peningkatan aktivitas perekonomian di kawasan Gunung Gambir melalui Wisata Agro Rengganis (WAR) yang difasilitasi PT. Perkebunan Nusantara (PTPN) XII sebagai bagian dari tanggung jawab sosial perusahaan mengindikasikan motif pembangunan citra dalam bentuk pemberdayaan. Penelitian ini bertujuan untuk mengidentifikasi beragam motif yang muncul dari kegiatan pemberdayaan di kawasan Gunung Gambir dengan menggunakan metode kualitatif. Perspektif yang digunakan dalam penelitian ini menggunakan teori legitimasi. Penelitian ini menemukan bahwa proses pemberdayaan yang dilakukan PTPN XII untuk meningkatkan kesejahteraan masyarakat melalui Wisata Agro Rengganis ditempuh dengan model kemandirian. Masyarakat diberikan ruang terbuka untuk menentukan dan mengembangkan potensi alam. PTPN berperan sebagai fasilitator yang menyediakan kebutuhan pengembangan, seperti pelatihan dan pendidikan. Mekanisme ini merupakan langkah efektif yang dapat meningkatkan taraf hidup masyarakat sekitar. Meskipun demikian, upaya keberlanjutan tidak menjadi bagian dari proses pemberdayaan, sehingga program yang dijalankan bertendensi pada pembangunan citra yang tujuannya hanya untuk menjaga hubungan baik antara PTPN XII dengan masyarakat demi keberlanjutan perusahaan.

Kata Kunci: Community empowerment, agrotourism, social welfare
Mobilitas Penduduk dan Kualitas Udara saat Pandemi COVID-19: Studi kasus DKI Jakarta
Authors: Alamsyah Purnama , Hakim Lukman Nul 
Published: June 2024

Penelitian ini bertujuan melihat sejauh mana mobilitas penduduk berpengaruh terhadap lingkungan, khususnya kualitas udara. Para peneliti sebelumnya telah mempelajari dampak mobilitas penduduk dan kaitannya dengan ekonomi, pola penyebaran penyakit, dan psikologis. Namun demikian masih sedikit yang meneliti bagaimana faktor lingkungan mempengaruhi dan dipengaruhi oleh mobilitas manusia. Bencana covid-19 secara kebetulan memberikan peluang bagi peneliti untuk mempelajari dengan kondisi yang sulit terulang, yaitu kondisi Kota Jakarta yang lebih lengang, dikarenakan mobilitas penduduk di Jakarta yang menurun drastis dikarenakan lockdown. Peneliti berusaha mempelajari fenomena tersebut menggunakan kerangka teori Driver–Pressure–State–Impact–Response (DPSIR). Metode penelitian yang dilakukan adalah kualitatif dengan mengkaji data mobilitas dari Google Mobility Index dan Rom tom Traffic index. Sementara sumber data respon publik diambil dari data cuitan di twitter yang diambil dari Twitter Archiving Google Sheet (TAGS) versi 6.1.7 mulai dari tanggal 15 Februari hingga 22 Mei 2020. Hasil penelitian menunjukkan bahwa penurunan mobilitas penduduk dalam berkendara ternyata tidak secara otomatis akan menurunkan kadar polutan di udara. Terdapat faktor lain yang berkontribusi terhadap polusi di Jakarta, yaitu industri yang berada di Jabodetabek yang mengelilingi Kota Jakarta. Artikel ini bermanfaat bukan saja bagi pemerhati lingkungan, melainkan juga para pengambil kebijakan, bahwa upaya memperbaiki kualitas udara di Kota Jakarta dapat dilakukan dengan mengatur mobilitas penduduk di Kota Jakarta, dan memonitor pihak industri.
Detection of Actinic Keratosis Skin Cancer Using Gray Level Co-occurrence Matrix Texture Extraction and Color Extraction With Support Vector Machine Classification
Authors: Putra Leonardus Sandy Ade , Gunawan Vincentius Abdi , Saragih Agus Sehatman 
Published: June 2024

Nowadays, humans tend to carry out activities during the day, both indoors and outdoors. Activities carried out outdoors cause human skin to often receive direct exposure to sunlight, which contains ultraviolet (UV) rays. Direct exposure to UV rays on the skin will harm the skin's health, which is the covering of the human body. Harmful effects on the skin usually include the skin becoming dark and dull, burns, and even causes cancer. One of the skin cancers that may appear on human skin is Actinic Keratosis (AK) cancer. AK cancer is a type of cancer that is classified as benign and can be cured with medical help. However, if this cancer is not caught early, it can become Squamous Cell Carcinoma (SCC), a type of malignant cancer. This research aims to design a system for identifying AK cancer types using color and texture feature extraction. RGB color feature extraction is obtained from image color segmentation and RGB values. The Gray Level Co-occurrence Matrix (GLCM) method is used to determine the texture of the skin cancer. Identification is carried out by a classification process using a Support Vector Machine (SVM), which can recognize the type of AK cancer. This research uses three classification methods: classification with color extraction, classification with texture extraction, and classification with color and texture extraction. Research shows that the highest level of accuracy in cancer recognition reaches 96% by combining color and texture extraction results as classification determinants. So, the system designed has succeeded in recognizing the type of AK cancer early on..
Resisting Ireland’s Necropolitics of Asylum: Refugee Voices in Irish Literature and the Arts
Authors: Rosende-Pérez Aida 
Published: June 2024

Abstract
This article examines the representation of the Irish Asylum system – known as Direct Provision – by an artist and a writer who have experienced it first-hand. Vukašin Nedeljković’s art project Asylum Archive (2007 –) and Melatu Okorie’s short stories “Shackles” (2010) and “This Hostel Life” (2017) respectively engage in the visual and literary representation of unlivable life in this carceral system, both articulating a compelling critique of the necropolitical violence exerted in and through its operations. Their work foregrounds the spatial and time dimensions of detention, highlighting the vulnerability of international protection applicants whose lives are not only bounded by confinement but also deferred in indefinite waiting. Besides, this article contends that these works go far beyond critique, offering very powerful critical insights into the inmates’ affective responses to the injustices of the asylum regime, and how these can potentially open spaces of dissent and resistance.
Monitoring of a rockfill embankment dam using TLS and sUAS point clouds
Authors: Bolkas Dimitrios , O’Banion Matthew , Laughlin Jordan , Prickett Jakeb 
Published: June 2024

Abstract
Terrestrial laser scanning (TLS) and camera-equipped small unmanned aircraft systems (sUAS) are two methods that are often used to produce dense point clouds for several monitoring applications. This paper compares the two methods in their ability to provide accurate monitoring information for rockfill embankment dams. We compare the two methods in terms of their uncertainty, data completeness, and field data acquisition/processing challenges. For both datasets, we derive an error budget that considers registration and measurement uncertainty. We also proceed to merge the TLS and sUAS data and leverage the advantages of each method. Furthermore, we conduct an analysis of the multiscale model-to-model cloud comparison (M3C2) input parameters, namely projection scale, normal scale, and sub-sampling of the reference point cloud, to show their effect on the M3C2 distance estimation. The theoretical methodologies and practical considerations of this paper can assist surveyors, who conduct monitoring of rockfill embankment dams using point clouds, in establishing reliable change/deformation estimations.
MST1 interactomes profiling across cell death in esophageal squamous cell carcinoma
Authors: Zhang Li , Gao Mingwei , Wu Yueguang , Liu Huijuan , Zhuang Xuehan , Zhou Yan , Song Qiqin , Bi Shanshan , Zhang Weimin , Cui Yongping 
Published: June 2024

Abstract

Objectives
Resistance to apoptosis in esophageal squamous cell carcinoma (ESCC) constitutes a significant impediment to treatment efficacy. Exploring alternative cell death pathways and their regulatory factors beyond apoptosis is crucial for overcoming drug resistance and enhancing therapeutic outcomes in ESCC.

Methods
Mammalian Ste 20-like kinase 1 (MST1) is implicated in regulating various cell deaths, including apoptosis, autophagy, and pyroptosis. Employing enhanced ascorbate peroxidase 2 (APEX2) proximity labeling coupled with immunoprecipitation-mass spectrometry (IP-MS), we elucidated the interactomes of MST1 across these three cell death paradigms.

Results
Proteomic profiling unveiled the functional roles and subcellular localization of MST1 and its interacting proteins during normal proliferation and various cell death processes. Notably, MST1 exhibited an expanded interactome during cell death compared to normal proliferation and chromosome remodeling functions consistently. In apoptosis, there was a notable increase of mitosis-associated proteins such as INCENP, ANLN, KIF23, SHCBP1 and SUPT16H, which interacted with MST1, alongside decreased expression of the pre-apoptotic protein STK3. During autophagy, the bindings of DNA repair-related proteins CBX8 and m6A reader YTHDC1 to MST1 were enhanced. In pyroptosis, LRRFIP2 and FLII which can inhibit pyroptosis increasingly binding to MST1.

Conclusions
Our findings delineate potential mechanisms through which MST1 and its interactomes regulate cell death, paving the way for further investigation to validate and consolidate these observations.
Défis sémiotiques de l’écriture du mort dans la littérature de la tombe
Authors: Bernoussi Mohamed 
Published: June 2024

Abstract
Cet article aborde la question du corps après la mort telle que la tradition arabo-musulmane le décrit d’abord dans le Coran et les hadiths (paroles du prophète Mahomet), puis dans l’abondante littérature de 'Adhâb al-Qabr (les terreurs salutaires de la tombe). C’est un sujet qui est étroitement lié à la sémiotique du corps, à la sémiotique de la religion et à la sémiotique de la culture car il est au carrefour de diverses problématiques relatives à la communication entre corps finis et vivants, au rôle structurant des lieux comme la tombe, l’au-delà ou dar al barzagh (équivalent – avec nuance – du purgatoire chrétien), et aux stratégies utilisées pour produire du sens dans un monde qui se veut intemporel, sans sens et sans espace, celui de la mort. Quel corps la tombe postule-t-elle ? Comment le récit du tombeau, avec ses catégories finies, joue-t-il avec un corps nié, mais en même temps indispensable ? On s’intéressera particulièrement à la question de la spatialité de la tombe, de la caractérisation du mort, de la nature des mondes possibles de la tombe, ainsi qu’à d’autres questions relatives au pacte communicatif qui s’établit entre le corps du mort et ceux des vivants.
Evaluation of biofilm formation and expression of psl, pel, alg genes of Pseudomonas aeruginosa in exposure to detergents
Authors: Al-Enazi Nouf M. 
Published: June 2024

AbstractPseudomonas aeruginosa has been in the center of attention for several years as an opportunistic human pathogen implicated in many severe acute and chronic infections particularly in immunocompromised patients. Its high persistence and resistance against many antimicrobial agents are mostly attributed to biofilm formation. Biofilms are microbial communities mainly consisting of extracellular polymeric substances that encapsulate bacteria together and protect them from extracellular stresses. This cell aggregation is a stress response that P. aeruginosa employes as a survival strategy during growth with the toxic detergents. This process has shown to involve several operons such as psl, pel, and alg. Here we used P. aeruginosa strain PAO1 in control group, 40 P. aeruginosa strains from sink and 40 strains from surface of public places. Biofilm formation and gene expression were measured before and after exposure to sub minimum inhibitory concentration (sub-MIC) of biocides chlorhexidine diacetate and benzalkonium chloride. The qRT-PCR and biofilm formation results demonstrated an increase in biofilm formation ability and gene expression of pslA/B and pelA/B in two groups collected from sink and surface in contrast to the control group. A remarkable increase was observed in the biofilm formation and expression of pslA in the bacterial strain collected from the sink after exposure to biocides chlorhexidine diacetate. Both Pel and Psl appeared to have redundant functions as structural scaffolds in biofilms. Sub-MIC levels of detergents can improve biofilm formation ability of P. aeruginosa and therefore trigger resistance.
The effectiveness of rehabilitation in vulvovaginal atrophy
Authors: Ampilogova D. М. , Solopova А. G. , Blinov D. V. , Ivanov А. Е. , Khlopkova S. V. , Bykovshchenko G. К. 
Published: June 2024

Objective: to evaluate the effectiveness and safety of rehabilitation programmes in patients with vulvovaginal atrophy (VVA).Material and methods. The study involved 350 patients with VVA in surgical (n=140) and natural (n=140) menopause, the control group included 70 women without VVA. Patients with VVA were distributed into groups receiving complex “active” rehabilitation (surgical menopause: group 1A, natural menopause: group 2A) and “passive” rehabilitation (surgical menopause: group 1B, natural menopause: group 2B). Body mass index (BMI), vaginal pH, carbohydrate profile with calculation of insulin resistance index (HOMA-IR), inflammatory markers leptin, interleukin-6, tumour necrosis factor alpha, serum magnesium, and safety profile with evaluation of adverse events related to rehabilitation measures were assessed over 24 months.Results. BMI decreased significantly in groups 1A and 2A. Vaginal pH at 1-year follow-up decreased in groups 1A and 2A, but increased in groups 2A and 2B. BMI was higher than normal in all patients with VVA, as well as in the control group, demonstrating preobesity (groups 1A, 2A, control group) or first-degree obesity (initially in group 1B and throughout follow-up in group 2B). HOMA-IR initially reflected postoperative insulin resistance in groups 1A and 2A, but in those receiving complex “active” rehabilitation the dynamics of its reduction was the most pronounced. The concentration of inflammatory markers was initially increased compared to the control group and decreased over time in groups 1A and 1B, but only leptin levels reached the control group values by the end of the study. Serum concentration of magnesium levels was 0.71±0.12 mmol/l in group 1A, 0.71±0.10 mmol/l in group 2A, 0.76±0.08 mmol/l in group 1B, 0.72±0.17 mmol/l in group 2B (magnesium deficiency). When organic magnesium salts in combination with pyridoxine were supplemented in groups 1A and 1B, serum magnesium levels were restored to normal from the 3rd month of follow-up. No adverse events were registered.Conclusion. The personalised programme of complex “active” rehabilitation in patients with VVA is more effective than “passive” rehabilitation with comparable safety profile. Its implementation into routine practice will contribute to the improvement of the quality of health care for such patients.