bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic factors associated with progression of smoldering multiple myeloma to symptomatic form
Authors: Rago Angela , Grammatico Sara , Za Tommaso , Levi Anna , Mecarocci Sergio , Siniscalchi Agostina , De Rosa Luca , Felici Stefano , Bongarzoni Velia , Piccioni Anna Lina , La Verde Giacinto , Pisani Francesco , Franceschini Luca , Paviglianiti Anna Lisa , Caravita Tommaso , Petrucci Maria Teresa , De Stefano Valerio , Cimino Giuseppe ,   on behalf of the Multiple Myeloma GIMEMA‐Latium Region Working Group
Published: July 2012

AbstractBACKGROUND:Smoldering multiple myeloma (SMM) presents a high risk of progression to symptomatic MM (sy‐MM). Herein, we analyzed some predictors of development of sy‐MM. In 144 patients with SMM, we also compared the risk of progression predicted by bone marrow plasma cell (BMPC) involvement on the bone marrow biopsy (BMB) versus bone marrow aspirates (BMA).METHODS:From January 1980 to July 2010, 397 patients with SMM observed in 12 centers of the Multiple Myeloma GIMEMA (Gruppo Italiano Malattie EMatologiche dell'Adulto) Latium Working Group have been analyzed. At progression to sy‐MM, the severity of clinical presentation was graded according to the need of intensive supportive care.RESULTS:After a median follow‐up of 135 months, the cumulative incidence of progression rates to sy‐MM were 45%, 55%, and 75% at 10, 15, and 20 years, respectively. Hemoglobin ≤12.5 g/dL, monoclonal component ≥2.5 g/dL, and BMPC ≥60% were the only parameters negatively affecting the cumulative incidence of progression. In particular, 10 of 397 (2.5%) patients with BMPC ≥60% had a 5.6‐fold increased risk of fast progression (within 2 years), which occurred with severe clinical manifestations in 62% of cases. BMB was more sensitive for the detection of BMPC involvement, even though BMA was a more reliable indicator of a rapid progression to sy‐MM.CONCLUSIONS:The highest risk of rapid evolution to sy‐MM and the severity of clinical manifestation at the progression suggest that SMM patients with a BMPC ≥60% should be treated soon after diagnosis. Moreover, BMPC is a more reliable index for progression to sy‐MM if assessed by BMA. Cancer 2012. © 2012 American Cancer Society.
Carbohydrate antigen 19‐9 is a prognostic and predictive biomarker in patients with advanced pancreatic cancer who receive gemcitabine‐containing chemotherapy
Authors: Bauer Todd M. , El‐Rayes Bassel F. , Li Xiaobai , Hammad Nazik , Philip Philip A. , Shields Anthony F. , Zalupski Mark M. , Bekaii‐Saab Tanios 
Published: July 2012

AbstractBACKGROUND:Carbohydrate antigen 19‐9 (CA19‐9) is a widely used biomarker in pancreatic cancer. There is no consensus on the interpretation of the change in CA19‐9 serum levels and its role in the clinical management of patients with pancreatic cancer.METHODS:Individual patient data from 6 prospective trials evaluating gemcitabine‐containing regimens from 3 different institutions were pooled. CA19‐9 values were obtained at baseline and after successive cycles of treatment. The objective of this study was to correlate a decline in CA19‐9 with outcomes while undergoing treatment.RESULTS:A total of 212 patients with locally advanced (n = 50) or metastatic (n = 162) adenocarcinoma of the pancreas were included. Median baseline CA19‐9 level was 1077 ng/mL (range, 15‐492,241 ng/mL). Groups were divided into those levels below (low) or above (high) the median. Median overall survival (mOS) was 8.7 versus 5.2 months (P = .0018) and median time to progression (mTTP) was 5.8 versus 3.7 months (P = .082) in the low versus high groups, respectively. After 2 cycles of chemotherapy, up to a 5% increase versus ≥ 5% increase in CA19‐9 levels conferred an improved mOS (10.3 vs 5.1 months, P = .0022) and mTTP (7.5 vs 3.5 months, P = 0.0005).CONCLUSIONS:In patients who have advanced pancreatic cancer treated with gemcitabine‐containing regimens baseline CA19‐9 is prognostic for outcome. A decline in CA19‐9 after the second cycle of chemotherapy is not predictive of improved mOS or mTTP; thus, CA19‐9 decline is not a useful surrogate endpoint in clinical trials. Clinically, a ≥ 5% rise in CA19‐9 after 2 cycles of chemotherapy serves as a negative predictive marker. Cancer 2013. © 2012 American Cancer Society.
Who makes the decision regarding the treatment of clinically localized prostate cancer–the patient or physician?
Authors: Song Lixin , Chen Ronald C. , Bensen Jeannette T. , Knafl George J. , Nielsen Matthew E. , Farnan Laura , Wallen Eric M. , Mishel Merle , Pruthi Raj S. , Mohler James L. , Godley Paul A. 
Published: July 2012

AbstractBACKGROUND:The current study examined how patients' sociodemographic, cancer‐related, and subjective affective factors impacted their role in treatment decision‐making.METHODS:The patient sample (N = 788) was taken from a prospective follow‐up study of a population‐based cohort. Participants included 343 African American and 445 Caucasian‐American patients with clinically localized prostate cancer. Multinomial logistic regression was used to investigate relations between the explanatory variables and the nominal 3‐level decision‐making variable: patient‐only, patient‐physician shared, and physician‐only.RESULTS:Approximately 41% of patients reported patient‐only decision‐making, 45% reported shared decision‐making, and 13% reported physician‐only decision‐making. The odds of patient‐only over physician‐only decision‐making were greater for younger men (vs those aged ≥ 65 years) (odds ratio [OR], 1.68; 95% confidence interval [95% CI], 1.03‐2.74), and were less for men with high (vs low) cancer aggressiveness (OR,0.29; 95% CI, 0.15‐0.55). The odds of shared over physician‐only decision‐making were less for men with high (vs low) cancer aggressiveness (OR, 0.40; 95% CI, 0.22‐0.73). Greater odds of patient‐only and shared decision‐making also were found to be associated with greater concerns about the physical impact of treatment and having enough time for decision‐making and lower scores of receiving advice from others.CONCLUSIONS:The findings of the current study indicate that, to facilitate a more patient‐oriented decision‐making process regarding treatment in those with clinically localized prostate cancer, clinicians need to tailor their interventions according to patient age and cancer aggressiveness, help reduce patient concerns and misconceptions regarding the physical impact of treatments, allow sufficient time for patients to consider treatment options, and assist patients in balancing advice and information received from different sources. Cancer 2013. © 2012 American Cancer Society.
Ancillary techniques on direct‐smear aspirate slides
Authors: Knoepp Stewart M. , Roh Michael H. 
Published: July 2012

AbstractNumerous cytologic techniques aimed at effectively acquiring patient material for molecular testing have been proposed. Such techniques are becoming ever more important in an age of personalized medicine. In this commentary, the authors explored some more commonly proposed techniques to aid in the molecular testing of cytologic specimens. These techniques include the use of cell blocks, direct cytologic smears, filter paper storage, frozen samples, and enriched cellular techniques such as ThinPrep and cytospin preparations. Direct‐smeared slides demonstrate excellent preservation of DNA, are easy to prepare, and are amenable to immediate adequacy at the time of the fine‐needle aspiration (FNA) procedure as well as effective subsequent tumor purity estimation. Cell block methods cannot be assessed at the time of FNA and often demonstrate insufficiency, whereas filter paper and frozen techniques do not allow for the direct assessment of the presence and purity of tumor cells in the sample. Direct‐smeared slides are emerging as the most effective preparation and storage medium of cytologic material to be used for molecular testing. Their cost‐effectiveness, ease of use, and reliability have cemented them as the optimal solution for cytopathologists to fulfill the role of providing advanced molecular testing on patient samples. Cancer (Cancer Cytopathol) 2013. © 2012 American Cancer Society.
A queuing model‐based approach for the analysis of transactional memory systems
Authors: Yu Xiao , He Zhengyu , Hong Bo 
Published: July 2012

SUMMARYIn this paper, we develop an analytical model of the execution efficiency of transactional memory (TM) systems. This model employs queuing theory to analyze the impact of an essential set of TM design parameters including the conflict rate, number of conflict detection/resolution points, and implementation overhead. The model is validated via extensive experiments. To demonstrate the effectiveness of the model, we further study the performance impact of two factors. Our study shows that, for a given TM‐based program, the frequency of performing conflict detection can be carefully chosen to minimize the mean transaction completion time. Our study also demonstrated the importance of reducing implementation overhead. We expect our study to be useful for designing TM systems and applications. Copyright © 2012 John Wiley & Sons, Ltd.
ISABELA for effective in situ compression of scientific data
Authors: Lakshminarasimhan Sriram , Shah Neil , Ethier Stephane , Ku Seung‐Hoe , Chang C. S. , Klasky Scott , Latham Rob , Ross Rob , Samatova Nagiza F. 
Published: July 2012

SUMMARYExploding dataset sizes from extreme‐scale scientific simulations necessitates efficient data management and reduction schemes to mitigate I/O costs. With the discrepancy between I/O bandwidth and computational power, scientists are forced to capture data infrequently, thereby making data collection an inherently lossy process. Although data compression can be an effective solution, the random nature of real‐valued scientific datasets renders lossless compression routines ineffective. These techniques also impose significant overhead during decompression, making them unsuitable for data analysis and visualization, which require repeated data access.To address this problem, we propose an effective method for In situ Sort‐And‐B‐spline Error‐bounded Lossy Abatement (ISABELA) of scientific data that is widely regarded as effectively incompressible. With ISABELA, we apply a pre‐conditioner to seemingly random and noisy data along spatial resolution to achieve an accurate fitting model that guarantees a ⩾0.99 correlation with the original data. We further take advantage of temporal patterns in scientific data to compress data by ≈ 85%, while introducing only a negligible overhead on simulations in terms of runtime. ISABELA significantly outperforms existing lossy compression methods, such as wavelet compression, in terms of data reduction and accuracy.We extend upon our previous paper by additionally building a communication‐free, scalable parallel storage framework on top of ISABELA‐compressed data that is ideally suited for extreme‐scale analytical processing. The basis for our storage framework is an inherently local decompression method (it need not decode the entire data), which allows for random access decompression and low‐overhead task division that can be exploited over heterogeneous architectures. Furthermore, analytical operations such as correlation and query processing run quickly and accurately over data in the compressed space. Copyright © 2012 John Wiley & Sons, Ltd.
Using Time‐Resolved Electrochemical Patterning to Gain Fundamental Insight into Aryl‐Radical Surface Modification
Authors: Torbensen Kristian , Malmos Kristoffer , Kanoufi Frederic , Combellas Catherine , Pedersen Steen U. , Daasbjerg Kim 
Published: July 2012

AbstractScanning electrochemical microscopy is used to carry out local free‐radical grafting at a gold surface through mild oxidation of an aryl hydrazine. The process can be deliberately controlled by creation of a local pH gradient at the tip. Comparison of the experimental results with simulations shows that the radial expansion of the pH profile in which successful grafting can be accomplished increases with increasing generation time of OH− and with decreasing initial concentration of the grafting precursor. Furthermore, the radial expansion is faster than the nucleation of the grafting process.
Utility‐based probabilistic call admission control for complete fairness in wireless networks
Authors: Tsiropoulos G.I. , Stratogiannis D.G. , Chen Hsiao‐Hwa , Cottis P.G. 
Published: July 2012

SUMMARYResource reservation or the other prioritization strategies adopted by Call Admission Control (CAC) schemes in wireless networks lead to unfair resource allocation to users belonging to different service classes (SCs) due to high divergence among the respective call blocking probabilities (CBPs). In this paper, we propose dynamic optimization of probabilistic CAC (P‐CAC) schemes to assure CAC fairness among users of different SCs in wireless networks. The approach is based on users utility combined with fairness optimization, aiming at dynamically determining the probability value in the P‐CAC scheme. This optimal probability is adjusted to network ongoing traffic, CBPs of each SC, prioritization levels characterizing the SCs supported, and the users risk aversion, which reflects their behavior toward the perceived QoS. The existence and uniqueness of the optimal probability that leads to absolute fairness among the users of a wireless network are proven. Copyright © 2012 John Wiley & Sons, Ltd.
A survey on TCP Incast in data center networks
Authors: Ren Yongmao , Zhao Yu , Liu Pei , Dou Ke , Li Jun 
Published: July 2012

SUMMARYIn high bandwidth, low latency data center networks, when multiple data senders simultaneously communicate with a single receiver, namely in many‐to‐one communication pattern, the burst data overload the receiver's switch buffers, which leads to Transmission Control Protocol (TCP) throughput collapse. This is the so‐called TCP Incast problem. It has become a new hot research topic in recent years. Also, many proposals have been put forward from the aspects of multiple layers including link layer, transport layer, and application layer, etc., to mitigate TCP Incast. In this paper, an in‐depth survey on these proposals is given, and the principles, merits, and drawbacks of the main proposals for solving the TCP Incast issue are analyzed and summarized. Copyright © 2012 John Wiley & Sons, Ltd.
Limited condition dependence of male acoustic signals in the grasshopper Chorthippus biguttulus
Authors: Franzke Alexandra , Reinhold Klaus 
Published: July 2012

AbstractIn many animal species, male acoustic signals serve to attract a mate and therefore often play a major role for male mating success. Male body condition is likely to be correlated with male acoustic signal traits, which signal male quality and provide choosy females indirect benefits. Environmental factors such as food quantity or quality can influence male body condition and therefore possibly lead to condition‐dependent changes in the attractiveness of acoustic signals. Here, we test whether stressing food plants influences acoustic signal traits of males via condition‐dependent expression of these traits. We examined four male song characteristics, which are vital for mate choice in females of the grasshopper
Chorthippus biguttulus. Only one of the examined acoustic traits, loudness, was significantly altered by changing body condition because of drought‐ and moisture‐related stress of food plants. No condition dependence could be observed for syllable to pause ratio, gap duration within syllables, and onset accentuation. We suggest that food plant stress and therefore food plant quality led to shifts in loudness of male grasshopper songs via body condition changes. The other three examined acoustic traits of males do not reflect male body condition induced by food plant quality.
Well‐Crystallized CO32–‐Type LiAl–LDH from Urea Hydrolysis of an Aqueous Chloride Solution
Authors: Kang Hongliang , Leoni Matteo , He Hongmei , Huang Gailing , Yang Xiaojing 
Published: July 2012

AbstractAn LiAl–layered double hydroxide (LiAl–LDH) was synthesized by autoclaving an aqueous solution of LiCl and AlCl3 with urea at 100–160 °C. Chemical and structural analyses show the resulting powder to be pure and well‐crystallized LiAl2(OH)6(CO3)0.5·yH2O (1 < y < 2). X‐ray powder diffraction reveals an apparent monoclinic C2/m symmetry and the presence of disorder in the arrangement of the layers. A detailed study of the reaction is also proposed, demonstrating that the LiAl–LDH does not form by homogeneous precipitation, but is the result of a one‐pot imbibition of the Al(OH)3 gel precursor by Li2CO3, favored by an increase in the pH.
An acs‐Type Metal–Organic Framework with an Unprecedented Undecanuclear Copper Cluster as Secondary Building Unit
Authors: Hu Sheng , Yu Fang‐Yong , Zhang Peng , Zhou Ai‐Ju 
Published: July 2012

AbstractAn undecanuclear copper(I)‐based coordination polymer with formula [Cu11Br5(amtd)6(MeCN)3] (1) is accessible by mixed‐solvothermal reaction of copper(I) bromide with 2‐amino‐5‐mercapto‐1,3,4‐thiadiazole (Hamtd) in acetonitrile and water. X‐ray structural analysis reveals that 1 has an acs topological network based on six‐connected {Cu11Br2S6} building blocks, interconnected by amtd– linkers. The undecanuclear copper cluster adopts the geometry of a bicapped trigonal prism, in which each triangular face of the {Cu5S6} trigonal prism is capped by an additional {Cu3Br} trigonal pyramid. The undecanuclear copper cluster is not common, and the discussion of the crystal structure is provided. IR spectroscopy, elemental analysis, and powder XRD analysis confirmed the phase‐purity of the as‐synthesized compound. The photoluminescence properties of 1 in the solid state at ambient temperature are also investigated.
Highly Efficient Synthesis of Multisubstituted Furans through Cupric Halide‐Mediated Intramolecular Halocyclization of 1‐(1‐Alkynyl)cyclopropyl Ketones
Authors: Zhu Mei , Fu Wei‐Jun , Xu Chen , Zou Guang‐Long , Wang Zhi‐Qiang , Ji Bao‐Ming 
Published: July 2012

AbstractA convenient and efficient method for the synthesis of 3‐halofurans was developed by using a cascade reaction between 1‐(1‐alkynyl)cyclopropyl ketones and cupric halide. Under mild reaction conditions, both 3‐chloro‐ and 3‐bromofuran derivatives were obtained in high yields. The reaction involves consecutive multiple bond formations, includingC–O and C–Br bonds, with high regioselectivity. Mechanistic aspects are described.
Straightforward Synthesis of Poly(dimethylsiloxane) Phases with Immobilized (1R)‐3‐(Perfluoroalkanoyl)camphorate Metal Complexes and Their Application in Enantioselective Complexation Gas Chromatography (Eur. J. Org. Chem. 21/2012)
Authors: Spallek Markus J. , Storch Golo , Trapp Oliver 
Published: July 2012

AbstractThe cover picture shows the leaves and blossom of the camphor tree cinnamomum camphora (photo taken at the botanical garden of the Ruprecht Karls University Heidelberg), a natural source of (+)‐(1R)‐camphor, which is the chiral key moiety of immobilized (1R)‐3‐(perfluoroalkanoyl)camphorate metal complexes. The beautiful white blossom forms a structure with tetrahedral elements, which are “mirrored” in the model of the polymeric chiral stationary phase. This chiral stationary phase is accessible in large quantities and can be used in complexation gas chromatography, showing exceptional high separation factors for a large number of stereoisomers. Details are discussed in the article by O. Trapp et al. on p. 3929 ff. magnified image
Determination of S(IV) Oxoanions at Poly[Ru(5‐NO2‐Phen)2Cl] Tetrapyridylporphyrin Glassy Carbon Modified Electrode
Authors: Dreyse Paulina , Quezada Diego , Honores Jessica , Aguirre María Jesús , Mendoza Leonora , Matsuhiro Betty , Villagra Diego , Isaacs Mauricio 
Published: July 2012

AbstractGlassy carbon electrodes modified with conducting polymers of Ni(II), Zn(II) and metal free tetraruthenated porphyrin were evaluated for reduction and oxidation processes of S(IV) oxoanions in Na2SO3/water‐ethanol at pH 1.0 and 3.5, showing electrocatalytic activity. A Ni(II) film was able to reduce the S(IV) oxoanions selectively in presence of high concentration of gallic acid. The Ni(II) film was also used as an amperometric sensor toward S(IV) oxoanions reduction in white wine samples showing a detection and quantification limit of 1.40 mg L−1 and 4.68 mg L−1, respectively. These results are promising for the electrochemical determination of S(IV) using conducting polymers from these macrocycles.
Complexes of Di‐ and Triazacrown Ethers with Heavy Metal Ions in Water Solution
Authors: Fedorova Olga , Fedorov Yury , Oshchepkov Maxim 
Published: July 2012

AbstractThis research concerns the analysis of the metal ion binding of benzo‐ and pyridine‐azacrown ether compounds of different structures and sizes by potentiometric method. The ligands are able to form 1 : 1 complexes with heavy metal ions (Cu+2, Pb+2, Cd+2, Ag+, Ni+2, Zn+2) in water of middle or high stability. To understand the selectivity in cation binding, different factors were considered.
Flow Potentiometric Injection Analysis of Uric Acid Using Lipid Stabilized Films with Incorporated Uricase on ZnO Nanowires
Authors: Tzamtzis Nikolaos , Psychoyios Vasillios N. , Nikoleli Georgia‐Paraskevi , Nikolelis Dimitrios P. , Psaroudakis Nikolas , Willander Magnus , Qadir Israr Muhammad 
Published: July 2012

AbstractA novel potentiometric uric acid biosensor was fabricated by immobilization of uricase into stabilized lipid films using zinc oxide (ZnO) nanowires as measuring electrode. Uricase was incorporated into the lipid film prior polymerization on the surface of well aligned ZnO nanowires resulting in a sensitive, selective, stable and reproducible uric acid biosensor. The potentiometric response was twice as large from previously reported values due to the presence of a cationic lipid in the lipid film. The sensor response had no interferences by normal concentrations of ascorbic acid, glucose, urea, proteins and lipids.
Transport and deposition of fine sediment in open channels with different aspect ratios
Authors: Bai Jing , Fang Hongwei , Stoesser Thorsten 
Published: July 2012

ABSTRACTThis paper investigates by means of several large eddy simulations how the channel aspect ratio affects the transport and settling of suspended sediments. The numerical method is successfully validated using data of a physical experiment of fine sediment net deposition in an open channel flow. The channel aspect ratio, A, is known to be the determining factor for the development, strength and distribution of the turbulence‐driven secondary flow, and it is demonstrated that A influences the primary flow, turbulence quantities and the transport and fate of fine sediments. The secondary flow locally supports or hinders the falling of fine sediment particles in a turbulent flow, which results in a non‐uniform deposition of fine sediments over the cross‐section. While the channel aspect ratio has a large influence on the distribution of suspended sediments within the cross‐section, its effect on the cross‐sectional averaged deposition is negligibly small. Copyright © 2012 John Wiley & Sons, Ltd.