bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measurement of fasting ketonuria and capillary blood glucose after main meals in women with gestational diabetes mellitus: How well is the metabolic picture captured?
Authors: Montaner Paquita , Ripollés Joaquim , Pamies Carme , Corcoy Rosa 
Published: March 2011

AbstractAim:  Metabolic monitoring of women with gestational diabetes mellitus (GDM) usually consists of measuring fasting ketonuria and postprandial capillary blood glucose (CBG) after main meals. We aimed to evaluate how this monitoring system captures the metabolic picture as compared to a scheme with a greater number of time points.Methods:  Thirty‐five women with GDM were recommended to follow a fractionated diet and trained in CBG and ketonuria monitoring. They were asked to monitor ketonuria before a main meal, and to monitor CBG at fasting and 1 h postprandial after any two of the six daily meals. Participants were requested to monitor different meals each day. The goal for 1 h postprandial CBG was <135 mg/dL (7.5 mmol/L). Ketonuria was defined as significant before a certain meal when ≥30% of measurements at that point were positive. Similarly, postprandial CBG was defined as abnormal after a meal when ≥30% measurements exceeded the goal.Results:  Ketonuria was significant in 22.5% of the time points and 41.2% of women had significant ketonuria at one or more time points; 61% of the time points and 35.7% of the women with significant ketonuria would have been undetected with monitoring restricted to breakfast. Postprandial CBG was abnormal in 17.6% of meals and 57% of women had abnormal postprandial CBG at one or more meals; 37.8% of points and 15% of women with abnormal postprandial CBG would have been undetected with monitoring restricted to main meals.Conclusion:  A substantial proportion of metabolic abnormalities in GDM women are not detected with a monitoring program that measures only fasting ketonuria and postprandial CBG after main meals.
Diversity, endemism and conservation of the freshwater crabs of China (Brachyura: Potamidae and Gecarcinucidae)
Authors: CUMBERLIDGE Neil , NG Peter K. L. , YEO Darren C. J. , NARUSE Tohru , MEYER Kirstin S. , ESSER Lara J. 
Published: March 2011

AbstractChina lies at the heart of the global center of freshwater crab diversity in tropical Asia, where the 2 most diverse families occur: Potamidae (505 species, 95 genera) and Gecarcinucidae (344 species, 59 genera). China stands out as the country with the highest species richness of freshwater crabs globally. Its fauna comprises 243 species in 37 genera and in 2 families, and species discovery is still progressing at a rapid pace. The vast majority of the species are distributed in southwest, south central and eastern China in the Oriental zoogeographical region. China also stands out as having a highly endemic freshwater crab fauna at the species level (96%) and at the genus level (78%). Although the recent International Union for the Conservation of Nature (IUCN) red list conservation assessment found only 6 out of 228 species (2%) to be threatened (5 potamids and 1 gecarcinucid), the majority (more than 75%) of Chinese species are regarded as data deficient, so the number of threatened species is likely to be a serious underestimate. Threats from increasing habitat destruction and pollution are a major concern due to the rapidly growing economy and massive developments taking place in China. There is therefore an urgent need for increased species exploration and for the development of a conservation strategy for China's threatened (and potentially threatened) endemic freshwater crab species.
Going Green to Stay in the Black: Transnational Capitalism and Renewable Energy
Authors: Harris Jerry 
Published: March 2011

AbstractSustainable energy use is rapidly developing, often with state support and patriotic political rhetoric. But the solar and wind energy industries are highly transnationalized and already inserted into global patterns of accumulation. While possibly solving some of the most pressing problems between capitalism and environmental sustainability, green capitalism still fails to address the contradiction between labor and capital. Therefore, any progressive strategy for social transformation must link the fair treatment of nature and labor together.
Sustainability Development-Eco-revolutionary Paradigms from Binary to Continuum Constructs
Authors: Patterson Rubin 
Published: March 2011

AbstractSustainable development and eco-revolution represent competing paradigms of progress, one emphasizing reform while the other emphasizes revolution with respect to an economy that is sustained by a restorative ecology. The first paradigm contends that a regenerative economy and restorative ecology are achievable only by a series of reforms while the second paradigm contends that the desired economy and ecology are achievable only via abrupt and decisive revolutionary change. This article argues that between the binary paradigmatic heuristic, there is a series or a parliament of possibilities between the two poles.
Reading the Temple Warning as a Greek Visitor
Authors: Llewelyn Stephen R. , van Beek Dionysia 
Published: March 2011

AbstractThe interpretation of the temple warning (CIJ 2.1400) has focused on the question of authorship rather than of readership. The present paper seeks to redress this oversight. The question is approached in terms of Hellenistic practice, Herod’s architectural innovations and the inscription’s language. It is argued that the inscription shows no trace of “translation” Greek, but rather that in terms of pragmatics, grammar and lexicography, the reader would naturally assume that its concepts are those of Hellenistic law. The reader’s assumption would be further confirmed by the architecture of the outer court. In other words, the Greek visitor would assume that the inscription was issued on the authority of the king, and not that of the priest.
Heteroceridae (Coleoptera) from Mongolia with description of Heterocerus kaszabi n.sp. and H. interspidulus n.sp.
Authors: Charpentier Reinhold 
Published: March 2011

AbstractThe following species of Heterocerus (Coleoptera, Heteroceridae) are recorded from Mongolia for the first time: parallelus Gebl., flexuosus Steph., kaszabi n.sp., fenestratus Thbg., obsoletus Curtis, interspidulus n.sp., intermedius Kiesw. and marmota Kiesw. H. fausti Reitter and H. heydeni Reitter are synonymized with H. flexuosus Steph., whereas H. tonkinensis Grouv., H. latus Grouv. and H. asiaticus Nomura are synonymized with H. fenestratus Thbg.
Crosstalk with insulin and dependence on PI3K/Akt/mTOR rather than MAPK pathways in upregulation of basal growth following long-term oestrogen deprivation in three human breast cancer cell lines
Authors: Ray Swagat , Darbre Philippa D. 
Published: March 2011

Abstract

Background: MCF-7, T-47-D, ZR-75-1 human breast cancer cell lines are dependent on oestrogen for growth but can adapt to grow during long-term oestrogen deprivation. This serves as a model for identification of therapeutic targets in endocrine-resistant breast cancer.

Methods: An overlooked complication of this model is that it involves more than non-addition of oestrogen, and inadequate attention has been given to separating molecular events associated with each of the culture manipulations.

Results: Insulin and oestradiol were shown to protect MCF-7 cells against upregulation of basal growth, demonstrating a crosstalk in the growth adaptation process. Increased phosphorylation of p44/42MAPK and c-Raf reflected removal of insulin from the medium and proliferation of all three cell lines was inhibited to a lesser extent by PD98059 and U0126 following long-term oestrogen/insulin withdrawal, demonstrating a reduced dependence on the MAPK pathway. By contrast, long-term oestrogen/insulin deprivation did not alter levels of phosphorylated Akt and did not alter the dose-response of growth inhibition with LY294002 in any of the three cell lines. The IGF1R inhibitor picropodophyllin inhibited growth of all MCF-7 cells but only in the long-term oestrogen/insulin-deprived cells was this paralleled by reduction in phosphorylated p70S6K, a downstream target of mTOR. Long-term oestrogen/insulin-deprived MCF-7 cells had higher levels of phosphorylated p70S6K and developed increased sensitivity to growth inhibition by rapamycin.

Conclusions: The greater sensitivity to growth inhibition by rapamycin in all three cell lines following long-term oestrogen/insulin deprivation suggests rapamycin-based therapies might be more effective in breast cancers with acquired oestrogen resistance.
The polysemy of agent nouns: diachronic, synchronic and contrastive evidence from French and Swedish
Authors: Rosenberg Maria 
Published: March 2011

Abstract
This study addresses Agent polysemy diachronically, synchronically, and contrastively. It examines the semantic structure of three French agentive formations, [VN/A]N/A compounds, and derivations with ‑eur and ‑ant. The semantics of four Swedish agentive formations which correspond to French [VN/A]N/A compounds are also studied. My results suggest that the polysemy of Agent is not uniformly hierarchically structured, with the Agent on top, for different agentive formations. They do not confirm that semantic extension emanates from the Agent. Instead, they speak in favour of blocking as the most plausible explanation for Agent polysemy and meaning extension.
Agent noun polysemy in Celtic: the suffix *‑mon‑ in Old and Middle Irish and its Proto-Indo-European origins
Authors: Remmer Ulla 
Published: March 2011

Abstract
The present paper gives an historical account of agent noun formations in ‑mon‑ in Old and Middle Irish, based on the Proto-Indo-European prehistory of this suffix. The patterning of agent nouns in ‑mon‑ in Irish points to a polysemy already inherited from the originally adjectival Proto-Indo-European derivates denoting affiliation. This is supported also by polysemous nominalizations in Ancient Greek. Formations in ‑mon‑, originally deverbal in Proto-Indo-European, came to be formally enlarged and functionally reinterpreted in Early Celtic, thus leading to the polysemy in Irish, with both deverbal and denominal ‑mon‑formations designating professions, occupations and functions as well as instruments and even animals.
Sociodemographic Heterogeneity in the Associations of Social Isolation With Mortality
Authors: Nakagomi Atsushi , Saito Masashige , Ojima Toshiyuki , Ueno Takayuki , Hanazato Masamichi , Kondo Katsunori 
Published: May 2024

ImportanceThere are limited data on whether the vulnerabilities and impacts of social isolation vary across populations.ObjectiveTo explore the association between social isolation and mortality due to all causes, cardiovascular diseases (CVD), and malignant neoplasms focusing on heterogeneity by sociodemographic factors.Design, Setting, and ParticipantsThis cohort study used a moderator-wide approach to examine the heterogeneity in the association of social isolation with all-cause, CVD, and malignant neoplasm mortality using baseline data from the Japan Gerontological Evaluation Study in 2010 and 2011. Eligible participants were adults aged 65 years or older without heart disease, stroke, cancer, or impaired activity of daily living across 12 Japanese municipalities. Follow-up continued until December 31, 2017, identifying 6-year all-cause, cardiovascular disease (CVD), and malignant neoplasm mortality. Logistic regression assessed effect modification by age, gender, education, income, population density, marital status, and employment on mortality associations. Data analysis was performed from September 13, 2023, to March 17, 2024.ExposureSocial isolation, determined by a 3-item scale (scores of 2 or 3 indicating isolation) was the primary exposure variable.Main Outcomes and MeasuresSix-year all-cause, CVD, and malignant neoplasms mortality.ResultsThis study included 37 604 older adults, with a mean (SD) age of 73.5 (5.9) years (21 073 women [56.0%]). A total of 10 094 participants (26.8%) were classified as experiencing social isolation. Social isolation was associated with increased all-cause (odds ratio [OR], 1.20 [95% CI, 1.09-1.32]), CVD (OR, 1.22 [95% CI, 0.98-1.52]), and malignant neoplasm mortality (OR, 1.14 [95% CI, 1.01-1.28]). Stratified analysis showed associations of social isolation with all-cause and malignant neoplasm mortality among people with high income (highest tertile all cause: OR, 1.27 [95% CI, 1.06-1.53]; malignant neoplasm: OR, 1.27 [95% CI, 1.02-1.60]), living in areas with high population density (highest tertile all cause: OR, 1.47 [95% CI, 1.26-1.72]; malignant neoplasm: OR, 1.38 [95% CI, 1.11-1.70]), not married (all cause: OR, 1.33 [95% CI, 1.15-1.53]; malignant neoplasm: OR, 1.25 [95% CI, 1.02-1.52]), and retirees (all cause: OR, 1.27 [95% CI, 1.14-1.43]; malignant neoplasm: OR, 1.27 [95% CI, 1.10-1.48]). Formal testing for effect modification indicated modification by population density and employment for all-cause mortality and by household income and employment for neoplasm mortality.Conclusions and RelevanceSocial isolation was associated with increased risks of all-cause, CVD, and malignant neoplasm mortality, with associations varying across populations. This study fills an important gap in research on social isolation, emphasizing its varied associations across demographic and socioeconomic groups.
Rectification in Ionic Field Effect Transistors Based on Single Crystal Silicon Nanopore
Authors: Hong Hao , Lei Xin , Wei Jiangtao , Zhang Yang , Zhang Yulong , Sun Jianwen , Zhang Guoqi , Sarro Pasqualina M. , Liu Zewen 
Published: May 2024

AbstractIonic FETs have enormous potential for energy conversion, sensing, and ionic circuits due to their efficient regulation of the nanochannel. Here ionic FETs based on single‐crystal silicon nanopores and the rectification of the fabricated devices are studied. The electrical characterization results demonstrated that since the silicon‐based nanopores have the advantage of modulating the surface charge due to their semiconductor nature and benefitting from the effective 3D gating effect on the nanochannel, the magnitude and polarity of surface charge can be modulated by the gate voltage. The rectification effect can be adjusted by applying a certain voltage and fulfilling a transition between anion selectivity and cation selectivity when the surface charge polarity is reversed. Moreover, current–voltage characteristics of the reported ionic FET can be switched between ohmic and diode‐like regimes. The proposed ionic FETs supply a novel platform to study the ionic properties and have great potential to be applied in large‐scale ionic circuits due to their excellent performance. Finally, simulation results prove the surface charge modulated by the gate voltage determines the magnitude and direction of rectification, which is consistent with the reported experiment result.
CASK pathogenic variant which expands the clinical spectrum for MICPCH syndrome in an adult patient
Authors: Tellerday Jack , Black Jennifer , Schuessler Donald C. , Dosa Nienke P. , Alcaraz Wendy , Lebel Robert Roger 
Published: May 2024

AbstractThe CASK gene and its product protein kinase have been associated with microcephaly with pontine and cerebellar hypoplasia (MICPCH) syndrome and various other neurodevelopmental disorders. Clinical presentation is highly variable and generally includes intellectual disability, neurological disorders, and dysmorphic features, at a minimum. We present the case of one of the oldest known currently living patients with MICPCH syndrome with additional features not previously described in the literature (midface retrusion, macroglossia, dental crowding, adolescent‐onset contractures at large joints, laxity at finger joints, and prominent wrist dystonia). Progressive hypertonicity throughout the patient's life has been managed with serial botulinum toxin injections. A comprehensive multimodal care team including physiatry, physical therapy, exercise therapy, and audiology has been assisting her with hearing deficits, communication skills, and mobility. This potentially expands the phenotype of MICPCH syndrome and provides information about the management of this condition into adulthood.
A Highly Selective Synthesis of (E)‐11‐Arylidenebenzo [4′,5′] thieno [2′,3′ : 4,5] Pyrimido [2,1‐a] Isoindol‐13(1H)‐ones via Copper‐Catalyzed Sonogashira Coupling and Hydroamination
Authors: He Heng , Wang Zhen‐Xu , Zhang Mei‐Mei , Liu Jian‐Quan 
Published: May 2024

AbstractAn efficient and highly selective reaction of 2‐(2‐bromophenyl)‐5,6,7,8‐tetrahydrobenzo [4,5] thieno[2,3‐d]pyrimidin‐4(3H)‐one and terminal alkyne has been developed under palladium‐free conditions by CuI‐catalyzed sequential Sonogashira coupling reaction and 5‐exo‐dig hydroamination reaction. A series of 11‐arylidene‐2,3,4,11‐tetrahydrobenzo [4′,5′]thieno [2′,3′ : 4,5]pyrimido [2,1‐a]isoindol‐13(1H)‐one derivatives with only the (E)‐configuration were obtained.
From molecular variations to behavioral adaptations: Unveiling adaptive epistasis in primate oxytocin system
Authors: Vargas‐Pinilla Pedro , S. Oliveira Fam Bibiana , Medina Tavares Gustavo , Lima Thaynara , Landau Luane , Paré Pâmela , de Cássia Aleixo Tostes Rita , Pissinatti Alcides , Falótico Tiago , Costa‐Neto Cláudio , Maestri Renan , Bortolini Maria Cátira 
Published: May 2024

AbstractObjectiveOur primary objective was to investigate the variability of oxytocin (OT) and the GAMEN binding motif within the LNPEP oxytocinase in primates.Materials and MethodsWe sequenced the LNPEP segment encompassing the GAMEN motif in 34 Platyrrhini species, with 21 of them also sequenced for the OT gene. Our dataset was supplemented with primate sequences of LNPEP, OT, and the oxytocin receptor (OTR) sourced from public databases. Evolutionary analysis and coevolution predictions were made followed by the macroevolution analysis of relevant amino acids associated with phenotypic traits, such as mating systems, parental care, and litter size. To account for phylogenetic structure, we utilized two distinct statistical tests. Additionally, we calculated binding energies focusing on the interaction between Callithtrix jacchus VAMEN and Pro8OT.ResultsWe identified two novel motifs (AAMEN and VAMEN), challenging the current knowledge of motif conservation in placental mammals. Coevolution analysis demonstrated a correlation between GAMEN, AAMEN, and VAMEN and their corresponding OTs and OTRs. Callithrix jacchus exhibited a higher binding energy between VAMEN and Pro8OT than orthologous molecules found in humans (GAMEN and Leu8OT).DiscussionThe coevolution of AAMEN and VAMEN with their corresponding OTs and OTRs suggests a functional relationship that could have contributed to specific reproductive and adaptive behaviors, including paternal care, social monogamy, and twin births, prominent traits in Cebidae species, such as marmosets and tamarins. Our findings underscore the coevolution of taxon‐specific amino acids among the three studied molecules, shedding light on the oxytocinergic system as an adaptive epistatic repertoire in primates.
Topical steroids for chronic rhinosinusitis without nasal polyps: A systematic review and meta‐analysis
Authors: Bhat Akash M. , Heiland Luke D. , Nguyen Shaun A. , Rathi Vinay K. , Schlosser Rodney J. , Soler Zachary M. 
Published: May 2024

AbstractBackgroundEvidence supporting topical steroids for the treatment of chronic rhinosinusitis without nasal polyposis (CRSsNP) is unclear. Recent trials describe alternative topical steroid delivery modalities, including rinses and exhalation delivery system (EDS), necessitating a re‐examination of the current literature.MethodsCochrane Library, CINAHL, PubMed, and Scopus databases were searched from inception to February 13, 2024 for placebo‐controlled randomized control trials on topical steroids used to treat CRSsNP, including topical spray, nasal irrigation, sinonasal catheter, and EDS modalities. Primary outcome measures included total symptom scores (TSS) (Δ) and response rates (odds ratio).ResultsTen trials (N = 751) were included for meta‐analysis, with a mean age of 47.5 years (range: 18–80 years; 95% confidence interval [CI]: 43.9–51.2 years). Topical steroids delivered by any method significantly improved TSS in CRSsNP patients (Δ0.4; 95% CI: 0.3–0.6; p < 0.0001). When stratified by allergy status, CRSsNP patients without allergy had significantly improved TSS when treated with EDS (Δ0.4; 95% CI: 0.1–0.7; p = 0.01), but not with topical spray (Δ0.04; 95% CI: −0.9 to 1.0; p = 0.94). Patients treated with EDS or sinonasal catheter responded significantly better compared to placebo (odds ratio [OR]: 3.4; 95% CI: 1.9–6.0; p < 0.0001; OR: 12.4; 95% CI: 1.8–83.8; p < 0.01), whereas patients treated with topical spray had no significant difference (OR: 1.8; 95% CI: 0.9–4.0; p = 0.12).ConclusionsTopical steroids are effective in treating CRSsNP, especially when delivered via EDS or sinonasal catheter. Future trials comparing steroid delivery mechanisms using validated outcome measures in CRSsNP populations are needed.
Heterogeneous blood‐brain barrier dysfunction in cerebral small vessel diseases
Authors: Ying Yunqing , Li Yingying , Yao Tingyan , Shao Xingfeng , Tang Weijun , Montagne Axel , Chabriat Hugues , Wang Danny J. J. , Wang Chaodong , Yang Qi , Cheng Xin 
Published: May 2024

AbstractINTRODUCTIONWe explored how blood‐brain barrier (BBB) leakage rate of gadolinium chelates (Ktrans) and BBB water exchange rate (kw) varied in cerebral small vessel disease (cSVD) subtypes.METHODSThirty sporadic cSVD, 40 cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), and 13 high‐temperature requirement factor A serine peptidase 1 (HTRA) ‐related cSVD subjects were investigated parallel to 40 healthy individuals. Subjects underwent clinical, cognitive, and MRI assessment.RESULTSIn CADASIL, no difference in Ktrans, but lower kw was observed in multiple brain regions. In sporadic cSVD, no difference in kw, but higher Ktrans was found in the whole brain and normal‐appearing white matter. In HTRA1‐related cSVD, both higher Ktrans in the whole brain and lower kw in multiple brain regions were observed. In each patient group, the altered BBB measures were correlated with lesion burden or clinical severity.DISCUSSIONIn cSVD subtypes, distinct alterations of kw and Ktrans were observed. The combination of Ktrans and kw can depict the heterogeneous BBB dysfunction.Highlights
We measured BBB leakage to gadolinium‐based contrast agent (Ktrans) and water exchange rate (kw) across BBB in three subtypes of cSVD.
CADASIL is characterized by lower kw, HTRA1‐related cSVD exhibits both higher Ktrans and lower kw, while sporadic cSVD is distinguished by higher Ktrans.
There are distinct alterations in kw and Ktrans among subtypes of cSVD, indicating the heterogeneous nature of BBB dysfunction.
Iron‐Catalyzed C−H Alkylation/Ring Opening with Vinylbenzofurans Enabled by Triazoles
Authors: Cattani Silvia , Pandit Neeraj Kumar , Buccio Michele , Balestri Davide , Ackermann Lutz , Cera Gianpiero 
Published: May 2024

AbstractWe report an unprecedented iron‐catalyzed C−H annulation using readily available 2‐vinylbenzofurans as the reaction pattern. The redox‐neutral strategy, based on cheap, non‐toxic, and earth‐abundant iron catalysts, exploits triazole assistance to promote a cascade C−H alkylation, benzofuran ring‐opening and insertion into a Fe−N bond, to form highly functionalized isoquinolones. Detailed mechanistic studies supported by DFT calculations fully disclosed the manifold of the iron catalysis.