bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sildenafil Effect on Atrial Natriuretic Peptide Level in Pulmonary Hypertensive Rats
Authors: Aljanabi Mukhallad A. , Alrabadi Nasr , Mahmoud Sahar H. , Haddad Razan , Alzoubi Karem H. 
Published: May 2024

Background:
Pulmonary Hypertension (PH) leads to changes in pulmonary vascular
architecture, hypertrophy of the right ventricle, and heart failure. Sildenafil is a drug that can
modulate PH by inducing smooth muscle relaxation and vasodilation.

Aims:
To investigate the ability of sildenafil to alleviate the monocritaline (MCT)-induced PH in
rats and to estimate the role and its effect on the atrial natriuretic peptide (ANP) levels.

Methods:
28 adult male rats were divided randomly into four groups: Group A (control group;
n=7). Group B (MCT-treated group; n=7) was given a single dose of MCT 60 mg/kg subcutaneously.
Group C (The reversal group; n=7) received a single dose of MCT 60 mg/kg subcutaneously
for three weeks and then sildenafil at 50 mg/kg/day, given daily for another three weeks.
Group D (The prevention group; n=7) simultaneously received a single dose of MCT 60 mg/kg
subcutaneously and sildenafil daily at 50 mg/kg for three weeks.

Results:
The animals in the prevention group showed a significant decrease in ANP levels compared
to the reversal and MCT-treated groups. This decrease was associated with a significant
reduction in the Fulton index ratio in the prevention group compared to the reversal group. The
nitric oxide levels were also significantly higher in the reversal group than in the control group.

Conclusion:
Preventive sildenafil treatment was associated with a significant decrease in ANP
levels and reduced MCT-induced cardiac hypertrophy in rats.
Experimental Study of Interference in Calcitonin Testing: A Case Report and Literature Review
Authors: Zhang Xiaofang , Liu Yixian , Liu Xiaoxuan , Shu Hua , Dong Zuoliang 
Published: May 2024

Background:
Calcitonin (CT) is a sensitive serum marker of medullary thyroid carcinoma
usually detected via immunoassays; however, its levels are easily disturbed by several
endogenous factors.

Objective:
The study aimed to discuss a case of suspected interference resulting in aberrant CT
values and review previous reports of CT interference.

Methods:
A female patient visited our clinic with a physical ultrasound examination showing a
slightly enlarged thyroid gland with small nodules. She had elevated CT levels, inconsistent
with the clinical presentation and other findings. We evaluated the results by retesting using the
same platform, platform validation, multiplex dilution, Polyethylene Glycol (PEG) precipitation,
heterophilic blocking tubes, and RET gene analysis.

Results:
Retesting CT using the same platform confirmed the high value obtained. However,
serial dilution of the sample produced nonlinear results, suggesting some interference. While
PEG precipitation did not significantly reduce the CT level, incubating the sample in HBTs
normalized the CT value, indicating interference from heterophilic antibodies. Gene sequencing
revealed no RET mutations.

Conclusion:
In cases where elevated CT levels are inconsistent with clinical presentations and
other findings, the laboratory technicians should communicate with clinicians, analyze the reasons
for the inconsistent results, and use different methods to verify the results. Accurate testing provides
realistic and reliable data for doctors and patients and helps to avoid unnecessary procedures.
Solid Lipid Nanoparticles: A Review of their Biomedical Applications and Preparation
Authors: Jana Mayukh , Biswas Ujjwal Kumar , Patra Chandra Sekhar , Debnath Biplab , Sharma Suraj , Naskar Sweet 
Published: May 2024

Abstract:
Solid lipid nanoparticles (SLNs) are gaining significant attention in the pharmaceutical
industry due to their biocompatibility and biodegradability, making them a popular functional
nanocarrier. SLNs are a popular nanocarrier due to their ability to bypass the spleen and liver, offer
high drug stability, and improve bioavailability, sterilization, immobilization, targeted drug release,
and biocompatible ingredients. This article discusses various SLN preparation techniques, including
high shear homogenization, hot homogenization, cold homogenization, microemulsion-based, solvent
evaporation, solvent emulsification-evaporation, supercritical fluid-based, spray drying, double
emulsion, and precipitation techniques, focusing on methodological aspects. This review discusses
the physicochemical behavior of SLNs, including drug loading, release, particle size, stability, cytotoxicity,
and cellular uptake, and their major biomedical applications.
Control Strategy and Parameter Optimization of Hybrid Vehicle Drive System
Authors: Li Penghui , Chen Guoqiang , Kang Jianli , Guo Desui , Kang Jincan 
Published: May 2024

Background:
Pure electric vehicles still have the problem with range anxiety, but hybrid
vehicles can solve this problem well. Parameter optimization and adaptation of control strategies
are the keys to improving the economy of hybrid vehicles.

Objective:
This study aimed to improve the economy of hybrid vehicles to get more mileage in the
same working conditions. On the basis of a large number of invention patents, this study establishes
and optimizes the parameters and control strategy of hybrid vehicles in order to obtain better driving
parameters and a more appropriate control strategy for hybrid vehicle drive system.

Methods:
The key parameters of each component of the drive system are defined under dynamic
objectives of hybrid vehicles. The control strategy adopts a logic gate-based approach to determine
driving mode and braking of hybrid vehicles by limiting the speed, SOC, and power demand. Finally,
the particle swarm optimization algorithm is used to optimize the key parameters to obtain the
economic optimal solution without losing the vehicle power.

Results:
In the China light-duty vehicle test cycle-passenger (CLTC-P) cycle condition, the optimized
parameters can improve the fuel economy of fuel economy by 16.06%, and in the worldwide
harmonized light vehicles test cycle (WLTC) cycle condition, the optimized parameters can improve
the fuel economy of hybrid vehicles by 12.17%.

Conclusion:
By establishing and optimizing driving system parameters and control strategy of the
hybrid vehicles, this study improves the economy and achieves the expected effect without losing
the vehicle power. However, in further research, driving conditions and mileage under different
working conditions should be further studied, and on this basis, the optimization of control strategies
should be continued.
Methods for the Encapsulation of Hydrophilic Drugs in Lipid-Based Nanocarriers, Solid Lipid Nanoparticles, and Nanostructured Lipid Carriers: A Short Review and Perspective
Authors: Singh Amit Kumar , Kumar Manish , Upadhyay Prabhat Kumar 
Published: May 2024

Abstract:
Hydrophilic drugs are proficient therapeutic drug candidates; however, their effective
delivery poses a formidable challenge. Therefore, the development of an efficient drug delivery
system demands a multifaceted approach. In recent decades, nanolipid carriers have emerged as
promising drug delivery systems, offering enhanced stability, improved bioavailability, and controlled
release profiles. Although nanolipid carriers have been widely investigated as carriers for
hydrophobic drugs and have demonstrated remarkable success in encapsulating hydrophobic
drugs, encapsulating a hydrophilic drug moiety still remains a challenge.
The current study provides a comprehensive review of innovative methods developed for the successful
encapsulation of hydrophilic drugs into nanolipid carriers. The first section of the study explores
the physicochemical properties of hydrophilic drugs and the inherent challenges associated
with their encapsulation in lipid-based carriers. The subsequent sections delve into the various
strategies employed to overcome these challenges. Emphasis is placed on novel formulation techniques
investigated for the encapsulation of hydrophilic drugs into nano lipid carriers. The present
review not only delineates the various traditional methods for high entrapment of hydrophilic
drugs but also underscores modifications to the hydrophilic drug candidates, facilitating their efficient
encapsulation into nanolipid carrier drug carriers.
This study explores the current state of knowledge regarding methods for encapsulating hydrophilic
drugs into nanolipid carriers. By addressing the challenges associated with hydrophilic drug encapsulation
and presenting innovative strategies, this review aims to provide valuable insights to
researchers and pharmaceutical scientists working in the field of nanomedicine and drug delivery.
The Role of Anxiety and Prosocial Behaviors on Adherence Behaviors to Prevent COVID-19 in University Students in the United States: Cross-Sectional Study
Authors: Corbera Silvia , Marín-Chollom Amanda M 
Published: May 2024

Abstract

Background
In situations of acute stress, individuals may engage in prosocial behaviors or risk-taking self-oriented behaviors. The COVID-19 pandemic created large stress-promoting conditions that impacted individuals’ decisions to adhere to COVID-19 preventative behaviors.

Objectives
The study aimed to examine the relationship between anxiety during the pandemic and adherence behaviors to prevent the spread of COVID-19, and the moderating influence of prosocial behaviors. We hypothesized that individuals with high anxiety during COVID-19 would adhere more to preventive COVID-19 behaviors than ones with low anxiety and that this relationship would be stronger in those individuals with higher prosocial behaviors.

Methods
A web-based survey was administered through the SONA web-based participant tool of the psychology department of a university in the Northeastern United States. A final sample of 54 undergraduate students completed web-based questionnaires during the second wave of the COVID-19 pandemic, from January to May 2021, which included demographic measures and surveys on prosocial behaviors, anxiety, and COVID-19 preventive behaviors. Moderation analyses were conducted using PROCESS in SPSS.

Results
Participants reported high levels of trait and state anxiety symptoms, most of them meeting or exceeding the cutoff criteria to be clinically meaningful (state anxiety: 47/54, 87%; trait anxiety: 38/44, 86%), and over 50% highly adhered to the COVID-19 preventive behaviors of wearing a face mask, using hand sanitizer, handwashing, coughing/sneezing into their elbow or a tissue, self-quarantining, maintaining social distance, avoiding social gatherings, and avoiding nonessential travel. No significant associations were observed between prosocial behavior, anxiety types, and adherence to COVID-19 preventive behaviors. However, when moderation analyses were conducted between anxiety types and adherence to COVID-19 preventive behaviors, results demonstrated a statistically significant interaction of public prosocial behavior with state anxiety (β=−.17, t53=−2.60; P=.01), predicting engagement in COVID-19 preventative behaviors. At high levels of anxiety, low levels of prosocial public behaviors were associated with higher engagement in COVID-19 preventative behaviors. In contrast, high levels of public prosocial behavior were associated with low engagement in COVID-19 preventative behaviors at higher levels of anxiety.

Conclusions
These results provide information that can aid in the creation of interventions that could increase adherence to COVID-19 preventative behaviors (Reviewed by the Plan P #PeerRef Community).
Time for Medicine and Public Health to Leave Platform X
Authors: Timpka Toomas 
Published: May 2024

Abstract
For more than 50 years, digital technologies have been employed for the creation and distribution of knowledge in health services. In the last decade, digital social media have been developed for applications in clinical decision support and population health monitoring. Recently, these technologies have also been used for knowledge translation, such as in the process where research findings created in academic settings are established as evidence and distributed for use in clinical practice, policy making, and health self-management. To date, it has been common for medical and public health institutions to have social media accounts for the dissemination of novel research findings and to facilitate conversations about these findings. However, recent events such as the transformation of the microblog Twitter to platform X have brought to light the need for the social media industry to exploit user data to generate revenue. In this viewpoint, it is argued that a redirection of social media use is required in the translation of knowledge to action in the fields of medicine and public health. A new kind of social internet is currently forming, known as the “fediverse,” which denotes an ensemble of open social media that can communicate with each other while remaining independent platforms. In several countries, government institutions, universities, and newspapers use open social media to distribute information and enable discussions. These organizations control their own channels while being able to communicate with other platforms through open standards. Examples of medical knowledge translation via such open social media platforms, where users are less exposed to disinformation than in general platforms, are also beginning to appear. The current status of the social media industry calls for a broad discussion about the use of social technologies by health institutions involving researchers and health service practitioners, academic leaders, scientific publishers, social technology providers, policy makers, and the public. This debate should not primarily take place on social media platforms but rather at universities, in scientific journals, at public seminars, and other venues, allowing for the transparent and undisturbed communication and formation of opinions.
Analisis Faktor Penyebab Rendahnya Pemberantasan Sarang Nyamuk Desa Gumuk Kecamatan Licin Kabupaten Banyuwangi
Authors: Perdaa Amalia Safira , Prayoga Diansanto 
Published: May 2024

Kasus Demam Berdarah Dengue (DBD) merupakan penyakit yang sering ditemukan didaerah tropis dan subtropis di wilayah Indonesia. Semua wilayah mempunyai risiko terjangkit penyakit DBD, karena virus penyebab dan nyamuk penularannya tersebar luas baik dirumah dan dilingkungan sekitar rumah kecuali lingkungan yang ketinggiannya lebih dari 1000 meter diatas permukaan laut. Kejadian Demam Berdarah Dengue (DBD) di Kabupaten Banyuwangi pada tahun 2019 berdasarkan data Dinas Kesehatan Kabupaten Banyuwangi ditemukan 138 kasus dan 5 penderita meninggal dunia. Kejadian DBD salah satu penyebabnya adalah rendahnya pemberantasan sarang nyamuk DBD. Desa Gumuk adalah suatu desa yang terletak di Kecamatan Licin, Kabupaten Banyuwangi dengan angka rendahnya pemberantasan sarang nyamuk (PSN DBD). Penelitian ini merupakan penelitian deskriptif dengan menggunakan pendekatan kualitatif. Tujuan penelitian adalah melihat faktor penyebab rendahnya pemberantasan sarang nyamuk di Desa Gumuk, Kecamatan Licin, Kabupaten Banyuwangi. Rendahnya pemberantasan sarang nyamuk (PSN) di desa Gumuk disebabkan oleh beberapa faktor antara lain; rendahnya tingkat pendidikan di masyarakat, letak geografis Desa Gumuk dan keterbatasan jumlah juru pemantau jentik (JUMANTIK).
Hubungan Depresi, Kecemasan dan Stres dengan Kejadian Insomnia pada Remaja Sekolah Menengah Atas Kota Surabaya
Authors: Tyas Laila Wahyuning 
Published: May 2024

Remaja merupakan kelompok usia rentan mengalami permasalahan kesehatan mental, salah satunya insomnia. Prevalensi kejadian insomnia pada remaja di dunia adalah sekitar 23,8%. Kasus insomnia pada remaja di Indonesia mencapai 38% pada daerah urban dan 37,7% pada wilayah sub-urban. Terdapat beberapa faktor yang menjadi penyebab insomnia diantaranya adalah depresi, kecemasan dan stres. Tujuan penelitian ini adalah untuk menganalisis hubungan antara depresi, kecemasan dan stres dengan kejadian insomnia pada remaja di Kota Surabaya. Penelitian ini menggunakan metode pendekatan cross sectional pada 413 siswa SMA Kota Surabaya berusia 15-18 tahun. Penelitian ini menggunakan teknik cluster random sampling dan proportional random sampling. Instrumen yang digunakan adalah Depression, Anxiety and Stress Scale-21 (DASS-21) dan Insomnia Severity Index (ISI). Hasil analisis data menggunakan tabulasi silang. Hasil penelitian menunjukkan kejadian insomia pada remaja Kota Surabaya berhubungan dengan depresi (p = 0,000), kecemasan (p = 0,000) dan stres (p = 0,000). Pada penelitian ini menunjukkan adanya hubungan yang bermakna antara tingkat depresi, kecemasan dan stres dengan kejadian insomnia pada remaja Kota Surabaya.
Hubungan antara Karakteristik, Intensitas Penggunaan Smartphone dan Niat dengan Kecenderungan Nomophobia pada Remaja SMA di Surabaya
Authors: Karindra Nisrina Auliyah Laras 
Published: May 2024

Indonesia menjadi salah satu negara yang menempati posisi 4 sebagai negara dengan jumlah pengguna smartphone terbanyak didunia yakni sebesar 240 juta pengguna. Fenomena yang terjadi saat ini adalah adanya kecenderunagn masyarakat dan remaja dalam menggunakan smartphone sehingga menyebabkan nomophobia. Dalam penelitian ini, peneliti bertujuan untuk mengetahui ada dan tidaknya hubungan antara intensitas penggunaan smartphone dan niat menggunakan smartphone dengan nomophobia. Jenis penelitian yang digunakan dalam penelitian ini adalah penelitian observasional analitik yaitu penelitian yang menjelaskan adanya hubungan antara variabel melalui pengujian hipotesa. Rancang bangun penelitian yang digunakan dalam penelitian ini merupakan penelitian Cross-sectional. Sampel pada penelitian ini adalah remaja di 5 SMA Negeri Surabaya sebanyak 414 siswa. Data dikumpulkan oleh peneliti dilakukan melalui metode pengambilan data primer dan sekunder. Berdasarkan analisis data hubungan intensitas penggunaan smartphone dengan nomophobia memiliki nilai pvalue sebesar 0,000. Hal ini menunjukkan bahwa terdapat hubungan antara intensitas penggunaan smartphone dengan Nomophobia. Hasil penelitian ini juga menunjukkan bahwa responden dengan intensitas penggunaan smartphone yang tinggi sebanyak 45,4% mengalami nomophobia berat. hasil dari analisis data hubungan dukungan sosial dengan nomophobia memiliki nilai pvalue sebesar 0,000. Hal ini menunjukkan bahwa terdapat hubungan antara niat menggunakan smartphone secara berlebihan dengan nomophobia. sebesar 51,3% responden yang memiliki niat tinggi untuk menggunakan smartphone secara berlebihan mengalami nomophobia berat dan 44,0 mengalami nomophobia sedang. Sedangkan yang mengalami nomophobia ringan hanya sebesar 4,7%. Kesimpulan pada penelitian ini adalah adalah terdapat hubungan antara jenis kelamin, intensitas penggunaan smartphone dan niat dalam penggunaan smartphone dengan nomophobia. Kemudian semakin tinggi intensitas penggunaan smartphone dan niat menggunakan smartphone semakin tinggi pula nomophobia yang dialami remaja.
Kata Kunci: Intensitas, Niat, Smartphone, Nomophobia
Hubungan Pengetahuan Dan Sikap Dengan Pemanfaatan Prolanis Pada Pasien Diabetes Melitus di Wilayah Kerja Puskesmas Kamonji Kota Palu
Authors: Wantah Firmansyah 
Published: May 2024

Indonesia mengalami kenaikan prevalensi Penyakit Tidak Menular (PTM) yang menjadi penyebab kematian tertinggi di Indonesia salah satunya penyakit Diabetes Melitus (DM). Prevalensi penderita DM di Indonesia menempati urutan ke 7 dunia dengan jumlah penderita sebanyak 10,7 juta jiwa. Laporan tahunan PTM Dinas Kesehatan Kota Palu menunjukkan dari 13 Puskesmas yang ada di Kota Palu jumlah kasus DM di Puskesmas Kamonji berada di angka tertinggi pada tahun 2020. Jumlah cakupan peserta di Puskesmas Kamonji pada tahun 2020 yang aktif mengikuti Prolanis hanya 5% dari 75% indikator yang harus dicapai. Program Pengelolaan Penyakit Kronis (Prolanis) merupakan salah satu strategi preventif dan promotif dari BPJS Kesehatan yang dilakukan untuk menurunkan atau mencegah komplikasi penyakit kronis (hipertensi dan DM tipe 2) yang diderita oleh peserta sekaligus meminimalisir pembiayaan pelayanan kesehatan. Tujuan penelitian ini untuk mengetahui hubungan antara tingkat pengetahuan, sikap, dukungan petugas kesehatan dan persepsi kebutuhan pelayanan kesehatan dengan pemanfaatan Prolanis pada pasien DM di wilayah kerja Puskesmas Kamonji Kota Palu. Jenis penelitian adalah survei analitik dengan pendekatan cross sectional. Pengambilan sampel menggunakan metode simple random sampling. Jumlah sampel 96 responden. Pengumpulan data dilakukan menggunakan kuesioner. Hasil penelitian menunjukkan ada hubungan tingkat pengetahuan (p=0,045), sikap (p=0,037), persepsi kebutuhan pelayanan kesehatan (p=0,003), dan tidak ada hubungan dukungan petugas kesehatan (p=0,862) dengan pemanfaatan Prolanis. Diharapkan kepada pihak Puskesmas untuk melakukan sosialisasi melalui Program Indonesia Sehat dengan Pendekatan Keluarga (PIS-PK) tidak hanya kepada penderita hipertensi dan DM melainkan pendekatan kepada keluarga penderita agar secara aktif memanfaatkan pelayanan Prolanis
Gambaran Pemberian Imunisasi Dasar Lengkap Pada Bayi di Provinsi Jawa Timur
Authors: Al Faruq Muhammad Umar 
Published: May 2024

Provinsi Jawa Timur merupakan salah satu daerah dengan angka kasus PD3I yang cukup tinggi, salah satunya jumlah kasus campak di tahun 2014 yaitu 1.071 kasus dan meningkat menjadi 2.937 kasus di tahun 2016. Terdapat ketimpangan antara tingginya kasus PD3I di Provinsi Jawa Timur yang tidak sesuai dengan cakupan pemberian Imunisasi Dasar Lengkap pada bayi di Provinsi Jawa Timur yang telah berhasil mencapai target sesuai dengan Rencana Pembangunan Jangka Menengah Nasional (RPJMN). Penelitian ini bertujuan untuk mengetahui gambaran pemberian Imunisasi Dasar Lengkap (IDL) pada bayi usia 0-12 bulan di Provinsi Jawa Timur. Penelitian ini bersifat deskriptif dengan pendekatan retrospektif. Populasi dalam penelitian ini yaitu seluruh bayi di Provinsi Jawa Timur yang melakukan Imunisasi Dasar Lengkap pada tahun 2016 hingga tahun 2018 yang tersebar di 29 kabupaten dan 9 kota. Pelaksanaan penelitian ini pada bulan Januari 2019 di Dinas Kesehatan Provinsi. Di Provinsi Jawa Timur pada tahun 2016 dari 571.137 bayi yang mendapat imunisasi lengkap 561.877 bayi (98,38%). Pada tahun 2017 dari 567.589 bayi yang mendapatkan imunisasi lengkap yaitu 547.362 bayi (96,44%). Pada tahun 2018 dari 562.943 bayi yang mendapatkan imunisasi lengkap sebanyak 532.181 bayi (94,54%). Penurunan angka cakupan Imunisasi Dasar Lengkap (IDL) pada bayi juga membuktikan masih adanya beberapa wilayah di Provinsi Jawa Timur yang belum mencapai target nasional. Belum semua bayi usia 0-12 bulan di Provinsi Jawa Timur mendapatkan imunisasi dasar secara lengkap.