bluuebunny/crossref_metadata_2025_split huggingface dataset:
Authors: Anggraeni R. K. , Andraini T. , Erlina L. 
Published: May 2024

Hibiscus sabdariffa Linn. (HSL) merupakan salah satu tanaman yang ada di Indonesia. Tanaman tersebut diketehui mengandung banyak senyawa aktif yang berkhasiat, seperti quercetin. Senyawa tersebut termasuk dalam golongan flavonoid yang diketahui berpotensi untuk menghambat aktifitas Glycogen Synthase Kinase-3? (GSK-3?). GSK-3? terlibat dalam berbagai aspek fungsi otak mulai dari perkembangan otak awal, hingga berbagai aspek fungsinya pada orang dewasa seperti perkembangan sinaptik yang tepat dan transmisi saraf. Disregulasi aktivitas GSK-3? baik pada perkembangan awal atau pada masa dewasa dapat menjadi predisposisi gangguan neuropsikiatri dan neurologis. Penelitian ini bertujuan untuk mengidentifikasi, mengevaluasi serta mengeksplorasi afinitas dan interaksi molekuler antara senyawa aktif HBS terhadap GSK-3? dengan menggunakan simulasi penambatan molekuler secara in silico. Penelitian ini diawali dengan preparasi GSK-3? dan penetapan sisi aktifnya menggunakan ligan alaminya. Selanjutnya dilakukan studi interaksi molekuler antara senyawa aktif HSL terhadap sisi aktif GSK-3? dengan metode molekuler docking. Hasil uji menunjukkan bahwa Methyl_ epigallocatechin dan 3-Methylquercetin memiliki kemampuan untuk berikatan dengan GSK-3?. Dari hasil molekuler docking dan farmokokinetik dapat disimpulkan bahwa senyawa Methyl_ epigallocatechin dan 3-Methylquercetin berpotensi menjadi inhibitor kompetitif GSK-3? berdasarkan studi in silico.
Kata kunci: GSK-3?, Diabetes Melitus, Hibiscus sabdariffa Linn.
ABSTRACT
Hibiscus sabdariffa Linn. (HSL) is one of the plants in Indonesia. These plants are known to contain many efficacious active compounds, such as quercetin. These compounds belong to the class of flavonoids which are known to have the potential to inhibit the activity of Glycogen Synthase Kinase-3? (GSK-3?). GSK-3? is involved in various aspects of brain function from early brain development, to various aspects of its function in adults such as proper synaptics and nerve transmission. Dysregulation of GSK-3? activity either in early development or in adulthood can predispose to neuropsychiatric and neurological disorders. This study aims to identify, evaluate and investigate the affinity and molecular interactions between HBS active compounds for GSK-3? using in silico molecular docking simulations. This study began with the preparation of GSK-3? and determination of its active site using natural ligands. Furthermore, a molecular interaction study was carried out between the HSL active compound and the active site of GSK-3? using the molecular docking method. The test results showed that Methyl_ epigallocatechin and 3-methylquercetin had the ability to bind to GSK-3?. From the results of molecular docking and pharmacokinetics, it can be concluded that the compounds Methyl-epigallocatechin and 3-Methylquercetin have the potential to become competitive inhibitors of GSK-3? based on in silico studies.
Keywords: GSK-3?, Diabetes Mellitus, Hibiscus sabdariffa Linn.
Authors: Sari N. L. S. , Laksono F. W. , . Salsabila , Kurniasari L. 
Published: May 2024

Penelitian ini bertujuan untuk menganalisis pengaruh suhu dan waktu pada rendemen ekstraksi berbantu gelombang ultrasonik daun jelatang (Urtica dioica L.). Sepuluh gram simplisia daun jelatang dimasukkan ke erlenmeyer dan ditambahkan 100 ml pelarut etanol 96% (1:10 b/v), kemudian diekstraksi dengan kombinasi suhu 30, 40, dan 50 oC selama 10, 20, dan 30 menit pada frekuensi 50 Hz. Berdasarkan riset yang telah dilakukan, rendemen tertinggi ekstrak daun jelatang adalah 8% dihasilkan pada suhu 40 °C dan waktu 30 menit. Sementara itu, rendemen terendah adalah 2% didapatkan pada suhu 30 °C dan waktu 10 menit. Hasil analisa fitokimia secara kualitatif menunjukkan bahwa ekstrak daun jelatang mengandung alkaloid, flavonoid, saponin dan steroid. Selanjutnya sampel dianalisis menggunakan alat FTIR untuk mengetahui gugus fungsi yang ada pada ekstrak daun jelatang. Dari hasil analisis gugus fungsi tersebut diketahui bahwa ekstrak daun jelatang secara dominan mengandung senyawa fenolik di dalamnya.
Kata kunci: analisis fitokimia, analisis gugus fungsi, daun jelatang, ekstraksi ultrasonik.
ABSTRACT
This research aimed to analyze the effect of temperature and time on the ultrasound-assisted extraction (UAE) yields of nettle leaf (Urtica dioica L.). Ten grams of simplicia was put into an Erlenmeyer and dissolved in 100 ml of 96% ethanol solvent (1:10 w/v), then extracted at a variation of temperatures of 30, 40, and 50 oC, during various times of 10, 20, and 30 minutes and with a frequency of 50 Hz. The results showed that the highest yield was 8% obtained at a temperature of 40 0C and an extraction time of 30 minutes, while the lowest yield was 2% gained at a temperature of 30 0C and an extraction time of 10 minutes. The qualitative analysis indicated that the extract contained alkaloids, flavonoids, saponins and steroids. The most optimal sample from the phytochemical test results was then analyzed using the FTIR to determine the functional groups contained in the nettle leaf extract. From the FTIR results, it was concluded that the nettle leaf extract predominantly consisted of phenolic compounds.
Keywords: nettle leaf, ultrasound assisted extraction, phytochemical analysis, functional group analysis.
THE EFFECT OF THE D185 MUTATION ON THE STABILITY AND FUNCTIONALITY OF RUBISCO LIKE PROTEIN (RLP) FROM CHROMOHALOBACTER SALEXIGEN BKL 5
Authors: Sudarmanto I. , Rohman M. S. , Artama W. T. 
Published: May 2024

In the case of Rubisco Like Protein (RLP) Chromohalobacter salexigen BKL 5 (RLP CS), which is halophilic, the presence of salt bridges (SB) is not too numerous but efficient enough to maintain stability in high salt stress. This study was to determine the effect of mutations SB at position 185 (D185/WT) on the stability and activity of RLP CS through an in-silico approach by replacing aspartic acid with glutamic acid and alanine (D185E and D185A). The methods used were Molecular Dynamics Simulations (MDS) and Molecular Docking (MD). The MDS was used to study molecular characteristics at the atomic level, while MD was for the interaction patterns of proteins and ligands. The results of the MDS analysis carried out at 10ns showed that the mutation at position 185 with alanine and glutamic acid changed the size/dimensional of RLP CS and affected its overall geometric structure. Interestingly, even though the structure has changed, the activity of the protein remains relatively constant, which is indicated by the results of MD, and has a relatively similar binding energy value of around -6.3 Kcal/mol.
Keywords: Chromohalobacter salexigen BKL 5, molecular docking, molecular dynamic simulation, mutation, saltbridge
KUALITAS SPERMATOZOA DAN BERAT ORGAN REPRODUKSI MENCIT (Mus musculus) SETELAH PEMBERIAN EKSTRAK BIJI KLABET (Trigonella foenum-graecum L.)
Authors: Utama Maulidya Rosa Putri , Yulihastuti Dwi Ariani , Sudirga Sang Ketut 
Published: May 2024

Indonesia is one of the countries known to have the highest biodiversity in the world. There are 18 types of herbs that have the potential as antifertility in men, one of which is the klabet plant or fenugreek. Klabet is believed by ordinary people to have properties to increase the production and quality of spermatozoa. According to previous research klabet has toxic effects that can inhibit fertility due to the content of phytochemicals in it. This study aims to determine the effect of fenugreek seed extract on the quality of spermatozoa and the weight of the reproductive organs of mice. The mice used were 20 male mice weighing about 25-30 grams divided into 4 treatments namely control (P0), 56 mg/kgBB (P1), 112 mg/kgBB (P2), 168 mg/kgBB (P3) with 5 repetitions. Giving treatment for 24 days. The method used is RAL (Complete Randomized Design) and the resulting data is analyzed using ANOVA. The parameters studied were testicular weight, epididymis weight, motility, morphology and number of male mouse spermatozoa. The results showed that there was a real difference (p≤0.05) between the control and treatment of the klabet seed extract on the quality of spermatozoa and the weight of the testicle but not significantly different (p≥0.05) to the weight of the epididyimis. Concentration of mice spermatozoa decreased by 10.60%, progressive spermatozoa motility decreased by 55.61%, nomal morphology decreased by 57.92%, while testicular weight decreased by 38.46%. The most effective dose of fenugreek seed extract used as an antifertility agent was a dose of 168 mg/kgBW (P3).
LAMA WAKTU PENGHENTIAN KONSUMSI SOJU TERHADAP KADAR ALKOHOL HATI, MORFOLOGI HATI, DAN GAMBARAN HEMATOLOGI TIKUS PUTIH
Authors: Mileva Tiffany Angelita Putri , Sudatri Ni Wayan , Wijana I Made Sara 
Published: May 2024

Alcohol consumption behaviors such as soju can increase metabolic syndrome disease. The elimination of alcohol in the body can determine the last time a person consumed alcohol through post-absorption assessment of alcohol. This study was conducted to determine changes in liver macroscopic morphology, liver alcohol levels and hematological features after stopping soju administration in white rats. The research design used was a complete randomized design with 4 treatments, namely the examination time P(0) 0 days, P(1) 3 days, P(2) 7 days, and P(3) 10 days. The methods used in this study are liver weight weighing, observation of macroscopic morphological conditions of the liver, examination of alcohol levels with gas chromatography-flame ionization detector and hematological examination with haematology analyzer. The results showed that stopping soju for 10 days had a significant effect on reducing liver weight and reducing fatty liver, decreased alcohol levels, red blood cell count, PCV percentage and hemoglobin levels that returned to the normal range. While the number of white blood cells does not show any influence and the value is below the normal range.
Keywords: alcohol, liver, blood profile, soju, white rat
KUALITAS DAN STATUS MUTU AIR IRIGASI UNTUK PADI SAWAH DI SUBAK YEHEMBANG, KABUPATEN JEMBRANA, BALI
Authors: Sundra I Ketut 
Published: May 2024

Research on the quality and status of irrigation water has been carried out for lowland rice in the Subak of Yehembang, Jembrana Regency, Bali. The sampling technique was carried out by Purposive Sampling. The analysis was carried out for physical, chemical and microbiological parameters. The level of feasibility of the results are matched with class 1 Water Quality Standards based on the Bali Governor Regulation No. 16 of 2016, while the status of water quality is determined by the Storet Method based on the Decree of the Minister of Environment No. 115 of 2003.
The results showed that in the rainy and dry seasons there were 3 parameters namely DO, BOD5, and Coliform Bacteria pass grade 1 water quality standards. For the quality status of Subak yehembang irrigation water for 4 locations during the rainy and dry seasons all are classified as moderately polluted
Keywords: subak, irrigation water, water quality, water quality statu.
Astronomy Education for the Persons with Disability: A Systematic Literature Review
Authors: Nawawi ‘Iffah Mohamad , Safiai Mohd Hafiz , Jamsari Ezad Azraai , Ashari Mohamad Zulfazdlee Abul Hassan , Ahmad Md. Yazid 
Published: May 2024

Objective: This research is carried out to deliberate the involvement of disabled people in the field of astronomy as well as the role, contribution and importance of astronomy to them. In addition, this study also examines the initiatives which have been taken to reduce the gap between communities in guaranteeing equal rights in the aspect of education for those groups.

Method: This study is a qualitative study which employs an approach of document analysis, through a comprehensive search of academic databases, government reports, and grey literature, relevant studies were analyzed using thematic analysis.

Results and Discussion: The results of this study found a lack in the number of programs and activities carried out for disabled people in Malaysia in the aspect of astronomical science education, in addition to a lack of suitable instruments and facilities to enable these groups to gain exposure to astronomy.

Research Implications: This study is anticipated to widen government awareness and venues to people with disabilities in ensuring that they have equal access and opportunities for full participation in the implemented astronomical science programmes.

Originality/Value: This study contributes to the literature by conducting a systematic review of the literature on astronomy education for the disabled person. The finding might have enlightened the needs of disabled people in astronomy education.
تولي أنجيلا ميركل وزيرة المرأة والشباب (كانون الثاني1991-تشرين الثاني1994)
Authors: عبد صالح مروج هادي , عبدالرحمن حارث 
Published: May 2024

عُدّت أنجيلا ميركل من الشخصيات السياسية الطموحة على الصعد كافة، إذ حكمت ألمانيا ستة عشر عاماً، استطاعت خلال تلك المدة إحداث تغيرات جذرية كبيرة في المؤسسات العامة، أهلتها تلك الاصلاحات بحق وعن جدارة اطلاق المؤرخين عليها (والدة الأمة الألمانية) وكذلك سُميت بـ(السيدة الحديدية الأوروبية).
اثناء مدة الأحداث التاريخية وسقوط جدار برلين المصيري بالنسبة للألمان ، انضمت العالمة الشابة إلى صفوف القوة السياسية الشعبية “حركة الصحوة الديمقراطية”، ثم موظفة في جهاز حكومة جمهورية ألمانيا الديمقراطية ، وحضرت بصفتها الجديدة العديد من الاجتماعات التي عقدت في سياق الاستعدادات لضم الأراضي الشرقية. و بعد الوحدة الالمانية ، أصبحت عضوًا في البوندستاغ. ونظراً لإمكاناتها العالية التي لفتت انتباه رئيس الحكومة المنتخبة هيلموت كول عينها في منصب وزارة شؤون المرأة والشباب.
مركز احياء التراث العلمي العربي التأسيس والهيكلية
Authors: شاكر كوثر محمود , احمد محمد يحيى 
Published: May 2024

يعد مركز احياء التراث العلمي العربي احد اهم المشاريع العلمية التي أسست في العراق والتي هدفت إلى احياء التراث العلمي العربي وسط موجات الانفتاح والتغريب التي شهدها العالم ابان حقبة الحرب الباردة فاستهدف البحث الحفاظ على الهوية العربية للعراق من خلال رعاية تراثه العلمي العربي، فانصب جهد المؤسسين من المهتمين بالتراث العلمي العربي في جامعة بغداد لأجل تشكيل هذا المركز، وفي بحثنا هذا سندرس التأسيس والهيكلية منذ نشأة المركز ولغاية عام 2018.
Performance of modified colistin broth disc elution vis-a-vis broth microdilution method for susceptibility testing of Enterobacterales
Authors: Kar Punyatoya , Mahapatra Ashoka , Malik Bilal Ahmad , Behera Bijayini , Mohanty Srujana 
Published: May 2024

Objectives:
Recently, Clinical and Laboratory Standards Institute (CLSI) has approved colistin broth disc elution (CBDE) to be a supplemental test. This requires multiple discs and tubes to get the desired concentrations of colistin -1, 2, and 4 µg/mL and 10 mL volume of cation-adjusted Mueller–Hinton broth for a single isolate. The present study was aimed to evaluate the performance of CBDE in a microtiter plate format modified (mCBDE) with the reference method broth microdilution (BMD) for detection of colistin resistance in carbapenem-resistant Enterobacterales (CRE) isolates.

Materials and Methods:
One hundred and sixty non-duplicate clinical CRE isolates (May 2021–April 2022) were simultaneously subjected for BMD and mCBDE. For mCBDE, colistin 10 µg discs and Mueller–Hinton broth no-2 control cations were procured from HiMedia, Mumbai, and drug concentrations were prepared following CLSI-M100Ed31. Results of mCBDE were compared with reference BMD (Minimum inhibitory concentration [MIC] ≤2 µg/mL – intermediate and ≥4 µg/mL – resistant).

Statistical Analysis:
The performance of mCBDE was compared with BMD and expressed in terms of Categorical, essential agreement (EA), very major error (VME), and major error (ME). The sensitivity and specificity were calculated using Fisher’s contingency Table.

Results:
Of the 160 CRE isolates, 152 had exactly the same minimal inhibitory concentration (MIC) in both the tests with four isolates having higher and four having lower colistin MIC by mCBDE, giving a major error of 2.1% and VME of 5.5%. Categorical and essential agreement of mCBDE were 97.5% and 98.7%, respectively.

Conclusions:
mCBDE is an easy, economical, and reliable alternative test for determining colistin susceptibility for CRE isolates. Further, large-scale study is needed to strengthen our observation.
MAIN ASPECTS OF PSYCHOLOGICAL CHARACTERISTICS OF EMOTIONAL BURNOUT OF MILITARY SERVANTS IN THE CONDITIONS OF LONG-TERM ARMED CONFLICTS
Authors: Avhustiuk Mariia , Demydiuk Volodymyr 
Published: May 2024

The paper describes the main psychological characteristics of emotional burnout of servicemen in the conditions of long-term armed conflicts according to cognitive, behavioural and emotional-volitional components. The results of the empirical study continue to expand the study of the psychological characteristics of military servants with emotional burnout. The main tools we used in the research were the methods of J. Rotter, G. Rezapkina, R. Bramson, V. Buzina and E. Vanderlik (cognitive component), A. Maklakov and S. Chermianyk, O. Shmeliov, L. Wasserman and N. Humeniuk, J. Crumbaugh, R. Lazarus, G. Eysenck, MMPI questionnaire (behavioural component), as well as questionnaires of V. Boiko, A. Zverkov and E. Eidman, V. Zunge, L. Wasserman, Ch. Spielberger (emotional-volitional component), aimed at identifying factors for preventing and overcoming emotional burnout. The results of the study showed that, at the trend level, the lowest level of emotional-volitional and the average level of cognitive components are the most characteristic for military servants, which indicates emotional disorders, neuroticism, the presence of anxiety, depression and prompts to consider the importance of correcting the components of emotional disorder. The results of the analysis can play an important role in the process of understanding the features of the cognitive, behavioural and emotional-volitional components of the emotional burnout of military servants in the conditions of long-term armed conflicts. A promising direction of emotional burnout research is the study of individual and gender characteristics of overcoming emotional disorders, elucidating the impact of emotional burnout on other spheres of military servants’ lives.
COPING STRATEGIES AS A COMPONENT OF SELF-REGULATION OF STUDENTS' EDUCATIONAL ACTIVITIES
Authors: Kalamaz Viktoriya , Krasnopir Artur , Doroshchuk Anna 
Published: May 2024

The article is devoted to the study of self-regulation of students' educational activities using two key methods – "Academic self-regulation" by R. Ryan and "Coping strategies" by R. Lazarus. The authors systematically consider various aspects of mental self-regulation and its influence on stress-coping strategies. In the article, the authors present the results of the analysis of the nature of the relationship between coping strategies and features of academic self-regulation in the context of higher education. It was found that most of the studied students demonstrate average levels of self-regulation according to the following scales: external regulation, introjective regulation, identified regulation, and self-motivation. It has been established that the variety of identified coping strategies indicates an individualized approach to overcoming stress in the conditions of higher education, however, the predominant orientation is towards solving problems. The results of a correlation analysis are presented, which allows us to determine the presence and nature of connections between specific types of self-regulation and selected strategies for overcoming stress. Direct and inverse correlations were established, which confirms the relationship between various aspects of self-regulation and the effectiveness of stress-coping strategies. It was concluded that the obtained results will contribute to a deeper understanding of the psychological mechanisms of self-regulation in the academic environment and the further development of pedagogical and psychological practice in the system of higher education.
Registration shutdown of tax invoices / calculations of adjustments: prerequisites and consequences
Authors: Bulavko I.M. , L.V. Chyzhevska 
Published: May 2024

This article covers the prerequisites and consequences of introducing a mechanism for the registration shutdown of tax invoices / calculations of adjustments. In fact, any innovations related to the administration of taxes and fees in the future have both negative and positive consequences for the state and business. That is why timely identification of negative consequences and shortcomings helps in the operational research and improvement of tax administration mechanisms, in order to increase the level of revenues to the state budget, reduce the level and risk of corruption and tax evasion, increase the level of business activity of businesses, as well as in order to prevent future scaling and generate concomitant negative consequences for the economy and budget of the country as a whole. We have studied current publications and articles of modern scientists and practitioners related to the administration of value-added tax. An assessment of the effectiveness of the current mechanism for the registration shutdown of tax invoices / calculations of adjustments is given. The main problems and incomplete development of the current procedure for the registration shutdown of tax invoices / calculations of adjustments, administrative and judicial appeals against decisions of regulatory authorities are highlighted. The consequences of introducing a mechanism for the registration shutdown of tax invoices / calculating adjustments on the level of economic activity of businesses, the judicial system of Ukraine and the tax system as a whole are studied. Based on the conducted research, we provided recommendations on ways to improve the existing system of value-added tax administration in the context of the mechanism for the registration shutdown of tax invoices / calculations of adjustments. In addition, options were proposed for combining electronic document management systems, tax audit, as additional monitoring tools for the electronic value-added tax administration service.