bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shrimp Extract Exacerbates Allergic Immune Responses in Mice: Implications on Clinical Diagnosis of Shellfish Allergy
Authors: Tong Wai Sze , Li Shanshan , Leung Nicki Y. H. , Wong Wing Tak , Leung Ting Fan , Leung Patrick S. C. , Chu Ka Hou , Wai Christine Y. Y. 
Published: May 2024

AbstractTropomyosin has been identified as the major cross-reactive shellfish allergen, but recent studies showed the presence of other clinically relevant allergens. This study aims at determining the allergic immune responses of mice sensitized with raw and boiled shrimp extracts in comparison to recombinant tropomyosin (rTM). Female Balb/c mice were intragastrically sensitized and challenged with raw, boiled shrimp or rTM. Systemic, cellular and humoral allergic responses were compared, while allergenicity of the extracts was also compared by skin prick test (SPT) and immunoblot on shrimp allergic subjects. We showed that rTM and shrimp extracts induced IgE- and Th2-mediated allergic responses in mice, distinguished by remarkable intestinal inflammation in small intestine across all regimens. Notably, boiled shrimp extract exhibited the highest sensitization rate (73.7% of mice developed positive TM-specific IgE response) when compared with raw extract (47.8%) and rTM (34.8%). Mice sensitized with boiled extract manifested the highest allergen-specific IgE and Th2 cytokine responses than the others. Immunoblot results indicated that tropomyosin remained the major allergen in extract-based sensitization and had stronger allergenicity in a heat-treated form comparing to untreated TM, which was in line with the SPT results that boiled extract induced larger wheal size in patients. Hemocyanin and glycogen phosphorylase were also identified as minor allergens associated with manifestation of shrimp allergy. This study shows that boiled extract enhanced sensitization and Th2 responses in agreement with the higher allergenicity of heat-treated TM. This study thus presents three shrimp allergy murine models suitable for mechanistic and intervention studies, and in vivo evidence implies higher effectiveness of boiled extract for the clinical diagnosis of shellfish allergy.
Ethnic minorities treated with new-generation drug-eluting coronary stents in two European randomised clinical trials
Authors: Ploumen Eline H. , Semedo Edimir , Doggen Carine J. M. , Schotborgh Carl E. , Anthonio Rutger L. , Danse Peter W. , Benit Edouard , Aminian Adel , Stoel Martin G. , Hartmann Marc , van Houwelingen K. Gert , Scholte Martijn , Roguin Ariel , Linssen Gerard C. M. , Zocca Paolo , von Birgelen Clemens 
Published: May 2024

Abstract
Background
Several ethnic minorities have an increased risk of cardiovascular events, but previous European trials that investigated clinical outcome after coronary stenting did not assess the patients’ ethnic background.

Aims
To compare ethnic minority and Western European trial participants in terms of both cardiovascular risk profile and 1‑year clinical outcome after percutaneous coronary intervention.

Methods
In the BIO-RESORT and BIONYX randomised trials, which assessed new-generation drug-eluting stents, information on patients’ self-reported ethnic background was prospectively collected. Pooled patient-level data of 5803 patients, enrolled in the Netherlands and Belgium, were analysed in this prespecified analysis. The main endpoint was target vessel failure after 1 year.

Results
Patients were classified as belonging to an ethnic minority (n = 293, 5%) or of Western European origin (n = 5510, 95%). Follow-up data were available in 5772 of 5803 (99.5%) patients. Ethnic minority patients were younger, less often female, more often current smokers, more often medically treated for diabetes, and more often had a positive family history of coronary artery disease. The main endpoint target vessel failure did not differ between ethnic minority and Western European patients (3.5% vs 4.9%, hazard ratio 0.71, 95% confidence interval 0.38–1.33; p = 0.28). There was also no difference in mortality, myocardial infarction, and repeat revascularisation rates.

Conclusions
Despite the unfavourable cardiovascular risk profile of ethnic minority patients, short-term clinical outcome after treatment with contemporary drug-eluting stents was highly similar to that in Western European patients. Further efforts should be made to ensure the enrolment of more ethnic minority patients in future coronary stent trials.
Association between multisite musculoskeletal pain and disability trajectories among community-dwelling older adults
Authors: Liu Peiyuan , Chen Hongbo , Tong Beibei , Zhu Disha , Cong Xiaomei , Shang Shaomei 
Published: May 2024

Abstract
Background
Pain is linked to disability, but how multisite musculoskeletal pain leads to disability over time is not well elaborated.

Objective
To examine the associations of multisite musculoskeletal pain with disability among a nationally representative cohort.

Design
We used data from the National Health and Aging Trends Study (NHATS) 2015-22. Disability was assessed by basic activities of daily living (ADL) and instrumental activities of daily living (IADL).

Participants
A total of 5557 individuals with multisite musculoskeletal pain dwelling in the community were included in this study.

Methods
Group-based trajectory models were applied to identify distinct profiles of disability in ADL and IADL. Design-based logistic regressions were used to examine associations among multisite musculoskeletal pain, disability, and dual trajectory group memberships, adjusted for sociodemographic, health status, behavioral, and mental characteristics.

Results
Persons who experienced multisite musculoskeletal pain were at higher risk of disability in ADL and IADL. We identified five heterogeneous disability trajectories and named them based on baseline levels and rates of increase over time. Approximately, 52.42% of older adults with multisite musculoskeletal pain were in trajectories with ADL and IADL declines, and 33.60% experienced a rapid decline. Multisite musculoskeletal pain was associated with elevated relative risk for the adverse disability trajectories, which generally increases with multisite musculoskeletal pain frequency and number of sites.

Conclusions
Persons with multisite musculoskeletal pain had a higher risk of disability. It is essential to adopt effective pain management strategies to maintain the independent living ability of older adults and to realize active aging.
Investigating the accuracy of classification in unbalanced data in order to diagnose two common potato leaf diseases (early blight and late blight) using image processing and machine learning
Authors: Talab Hassan Koroshi , Mohammadzamani Davood , Parashkoohi Mohammad Gholami 
Published: May 2024

AbstractThis study aimed to classify potato disease as early blight, late blight, and healthy leaves using color image processing techniques, data imbalance and feature extraction techniques. To this end, two groups of potato disease leaves with similar symptoms and one group of healthy leaves were considered. A new method based on increasing or decreasing image data using Over-Sampling and Under-Sampling techniques was used to balance them. For this purpose, after separating the diseased area from the leaf surface, the features were extracted. In total, 45 color features, 99 texture features were extracted from each of the three color spaces RGB, l*a*b and HSV, and 6 shape features were extracted from the images. Then classification was done by Random Forest. The classification accuracy results for three proposed models including classification with Original, Over-Sampling and Under-Sampling dataset were 87.89, 91.09 and 96.17%, respectively. Also, the most effective features extracted for the diagnosis of potato diseases were selected by the Relief feature selection algorithm. The results show that texture features contribute more to disease classification and data balancing techniques can increase classification accuracy. In addition, the results show that features extracted from different color spaces can improve disease diagnosis performance and help data engineers to increase the amount of features extracted and compare their performance. This study can be used in future research to classify potato diseases and other plant diseases, and its results can help researchers in their efforts.
Association Between Vitamin D Level and Clinical Outcomes of Assisted Reproductive Treatment: A Systematic Review and Dose-Response Meta-Analysis
Authors: Xu Chenhao , An Xinqi , Tang Xiumei , Yang Yunxiao , Deng Qi , Kong Quanling , Hu Ying , Yuan Dongzhi 
Published: May 2024

AbstractThe investigation about association between vitamin D level and clinical outcomes of assisted reproductive treatment showed various outcomes. This study aimed to review the correlation between vitamin D and outcomes of assisted reproductive treatment. The search was registered on the PROSPERO database (CRD42023458040). PubMed, Embase, Medline, ClinicalTrials.gov, and Cochrane databases were searched up to July 2023. Twenty-three observational studies were selected for meta-analysis. Comparing groups with deficient and ‘insufficient + sufficient’ vitamin D level, meta-analysis showed positive correlation between clinical pregnancy rate and vitamin D (OR 0.81, 95%CI: 0.70, 0.95, P = 0.0001). Comparing groups with ‘deficient + insufficient’ and sufficient vitamin D level, meta-analysis showed positive correlation between vitamin D and clinical pregnancy rate (OR 0.71, 95%CI: 0.55, 0.91, P = 0.006), vitamin D and live birth rate (OR 0.69, 95%CI: 0.54, 0.89, P = 0.003). Subgroup analysis did not show the source of high heterogeneity. No correlation was found in biochemical pregnancy rate, ongoing pregnancy rate, miscarriage rate and implantation rate. In dose-response meta-analysis, a nonlinear association was found between vitamin D levels and outcomes when levels are below approximately 24 ng/L. The study shows that vitamin D level is associated with clinical pregnancy rate and live birth rate. Low vitamin D level does not influence biochemical pregnancy rate, ongoing pregnancy rate, miscarriage rate and implantation rate. Furthermore, 24 ng/L may be a possible threshold of vitamin D concentration in assisted reproduction therapy.
The association between childhood blood lead levels and proximity to airports in Colorado
Authors: Berg Kevin , Snow Megan , Richardson Kristy 
Published: May 2024

Abstract
Background
In October 2023, the U.S. Environmental Protection Agency announced a final endangerment finding that leaded aviation gasoline (avgas) contributes to air pollution that is harmful to public health. This study evaluates the evidence for a link between living in proximity to airports and children’s blood lead levels in Colorado.

Methods
We analyzed the association between childhood blood lead levels (BLLs) and proximity to airport point locations in children tested for lead in Colorado over a 10-year study period (2011–2020) using a correlated random effects model with bootstrapped standard errors (N = 56,002 observations, 47,322 individuals). Along with distance from airport point locations, we identified the number of days sampled children lived downwind of their nearest airport during the 60 days prior to their test date. We also adjusted the model for age, sex, detection limit, test type, sample order, seasonality, time, proximity to lead-releasing facilities, estimated monthly aircraft traffic, and demographic characteristics of the surrounding neighborhood.

Results
Our primary model estimates that living one mile (1.6 km) further from airport point locations decreases mean blood lead levels by 0.068 µg/dL. Additional analysis estimates that living one mile further from airport point locations decreases the odds of having a blood lead level ≥ 3.5 µg/dL by 13.2%.

Conclusion
Our results suggest that lead emissions from aircraft using leaded avgas have a small but statistically significant effect on the BLLs of children living near airport point locations in Colorado. While the risk from proximity to airports is likely less than the risks associated with deteriorating lead paint and dust, our findings highlight the value of lead testing in children who may be at risk of exposure from all sources, including those who live near airports.
On divisorial stability of finite covers
Authors: Dervan Ruadhaí , Papazachariou Theodoros Stylianos 
Published: May 2024

Abstract
Divisorial stability of a polarised variety is a stronger – but conjecturally equivalent – variant of uniform K-stability introduced by Boucksom–Jonsson. Whereas uniform K-stability is defined in terms of test configurations, divisorial stability is defined in terms of convex combinations of divisorial valuations on the variety.
We consider the behaviour of divisorial stability under finite group actions and prove that equivariant divisorial stability of a polarised variety is equivalent to log divisorial stability of its quotient. We use this and an interpolation technique to give a general construction of equivariantly divisorially stable polarised varieties.
Orthogonality relations for deep level Deligne–Lusztig schemes of Coxeter type
Authors: Dudas Olivier , Ivanov Alexander B. 
Published: May 2024

Abstract
In this paper, we prove some orthogonality relations for representations arising from deep level Deligne–Lusztig schemes of Coxeter type. This generalizes previous results of Lusztig [Lus04], and of Chan and the second author [CI21b]. Applications include the study of smooth representations of p-adic groups in the cohomology of p-adic Deligne–Lusztig spaces and their relation to the local Langlands correspondences. Also, the geometry of deep level Deligne–Lusztig schemes gets accessible, in the spirit of Lusztig’s work [Lus76].
Optimized Predictive Coverage by Averaging Time‐Windowed Bayesian Distributions
Authors: Hsueh Han‐Fang , Guthke Anneli , Wöhling Thomas , Nowak Wolfgang 
Published: May 2024

AbstractHydrogeological models require reliable uncertainty intervals that honestly reflect the total uncertainties of model predictions. The operation of a conventional Bayesian framework only produces realistic (interpretable in the context of the natural system) inference results if the model structure matches the data‐generating process, that is, applying Bayes' theorem implicitly assumes the underlying model to be true. With an imperfect model, we may obtain a too‐narrow‐for‐its‐bias uncertainty interval when conditioning on a long time‐series of calibration data, because the assumption of a quasi‐true model becomes too strict. To overcome the problem of overconfident posteriors, we propose a non‐parametric Bayesian method, called Tau‐averaging method: it applies Bayesian analysis on sliding time windows along the data time series for calibration. Thus, it obtains so‐called transitional posteriors per time window. Then, we average these into a wider predictive posterior. With the proposed routine, we explicitly capture the time‐varying impact of model error on prediction uncertainty. The length of the calibration window is optimized to maximize goal‐oriented statistical skill scores for predictive coverage. Our method loosens the perfect‐model‐assumption by conditioning only on small windows of the data set at a time, that is, it assumes that “the model is sufficient to follow the system dynamics for a smaller duration.” We test our method on two cases of soil moisture modeling and show how it improves predictive coverage as compared to the conventional Bayesian approach. Our findings demonstrate that the proposed method convincingly overcomes the overconfidence drawback of Bayesian inference under model misspecification and long calibration time‐series.
Comparison of the ABC and ACMG systems for variant classification
Authors: Houge Gunnar , Bratland Eirik , Aukrust Ingvild , Tveten Kristian , Žukauskaitė Gabrielė , Sansovic Ivona , Brea-Fernández Alejandro J. , Mayer Karin , Paakkola Teija , McKenna Caoimhe , Wright William , Markovic Milica Keckarevic , Lildballe Dorte L. , Konecny Michal , Smol Thomas , Alhopuro Pia , Gouttenoire Estelle Arnaud , Obeid Katharina , Todorova Albena , Jankovic Milena , Lubieniecka Joanna M. , Stojiljkovic Maja , Buisine Marie-Pierre , Haukanes Bjørn Ivar , Lorans Marie , Roomere Hanno , Petit François M. , Haanpää Maria K. , Beneteau Claire , Pérez Belén , Plaseska-Karanfilska Dijana , Rath Matthias , Fuhrmann Nico , Ferreira Bibiana I. , Stephanou Coralea , Sjursen Wenche , Maver Aleš , Rouzier Cécile , Chirita-Emandi Adela , Gonçalves João , Kuek Wei Cheng David , Broly Martin , Haer-Wigman Lonneke , Thong Meow-Keong , Tae Sok-Kun , Hyblova Michaela , den Dunnen Johan T. , Laner Andreas 
Published: May 2024

AbstractThe ABC and ACMG variant classification systems were compared by asking mainly European clinical laboratories to classify variants in 10 challenging cases using both systems, and to state if the variant in question would be reported as a relevant result or not as a measure of clinical utility. In contrast to the ABC system, the ACMG system was not made to guide variant reporting but to determine the likelihood of pathogenicity. Nevertheless, this comparison is justified since the ACMG class determines variant reporting in many laboratories. Forty-three laboratories participated in the survey. In seven cases, the classification system used did not influence the reporting likelihood when variants labeled as “maybe report” after ACMG-based classification were included. In three cases of population frequent but disease-associated variants, there was a difference in favor of reporting after ABC classification. A possible reason is that ABC step C (standard variant comments) allows a variant to be reported in one clinical setting but not another, e.g., based on Bayesian-based likelihood calculation of clinical relevance. Finally, the selection of ACMG criteria was compared between 36 laboratories. When excluding criteria used by less than four laboratories (<10%), the average concordance rate was 46%. Taken together, ABC-based classification is more clear-cut than ACMG-based classification since molecular and clinical information is handled separately, and variant reporting can be adapted to the clinical question and phenotype. Furthermore, variants do not get a clinically inappropriate label, like pathogenic when not pathogenic in a clinical context, or variant of unknown significance when the significance is known.
Observation of a promethium complex in solution
Authors: Driscoll Darren M. , White Frankie D. , Pramanik Subhamay , Einkauf Jeffrey D. , Ravel Bruce , Bykov Dmytro , Roy Santanu , Mayes Richard T. , Delmau Lætitia H. , Cary Samantha K. , Dyke Thomas , Miller April , Silveira Matt , VanCleve Shelley M. , Davern Sandra M. , Jansone-Popova Santa , Popovs Ilja , Ivanov Alexander S. 
Published: May 2024

AbstractLanthanide rare-earth metals are ubiquitous in modern technologies1–5, but we know little about chemistry of the 61st element, promethium (Pm)6, a lanthanide that is highly radioactive and inaccessible. Despite its importance7,8, Pm has been conspicuously absent from the experimental studies of lanthanides, impeding our full comprehension of the so-called lanthanide contraction phenomenon: a fundamental aspect of the periodic table that is quoted in general chemistry textbooks. Here we demonstrate a stable chelation of the 147Pm radionuclide (half-life of 2.62 years) in aqueous solution by the newly synthesized organic diglycolamide ligand. The resulting homoleptic PmIII complex is studied using synchrotron X-ray absorption spectroscopy and quantum chemical calculations to establish the coordination structure and a bond distance of promethium. These fundamental insights allow a complete structural investigation of a full set of isostructural lanthanide complexes, ultimately capturing the lanthanide contraction in solution solely on the basis of experimental observations. Our results show accelerated shortening of bonds at the beginning of the lanthanide series, which can be correlated to the separation trends shown by diglycolamides9–11. The characterization of the radioactive PmIII complex in an aqueous environment deepens our understanding of intra-lanthanide behaviour12–15 and the chemistry and separation of the f-block elements16.
Two-year safety outcomes of iPS cell-derived mesenchymal stromal cells in acute steroid-resistant graft-versus-host disease
Authors: Kelly Kilian , Bloor Adrian J. C. , Griffin James E. , Radia Rohini , Yeung David T. , Rasko John E. J. 
Published: May 2024

AbstractThe first completed clinical trial of induced pluripotent stem cell (iPS cell)-derived cells was conducted in 15 participants with steroid-resistant acute graft-versus-host disease. After intravenous infusion of mesenchymal stromal cells (CYP-001 derived from a clone of human iPS cells), we reported the safety, tolerability and efficacy within the primary evaluation period at day 100. We now report results at the 2-year follow-up: 9 of 15 (60%) participants survived, which compares favorably with previously reported outcomes in studies of steroid-resistant acute graft-versus-host disease. Causes of death were complications commonly observed in recipients of allogeneic hematopoietic stem cell transplantation, and not considered by the investigators to be related to CYP-001 treatment. There were no serious adverse events, tumors or other safety concerns related to CYP-001. In conclusion, systemic delivery of iPS cell-derived cells was safe and well tolerated over 2 years of follow-up, with sustained outcomes up to 2 years after the first infusion. ClinicalTrials.gov registration: NCT02923375.
Preparation and characterization of hybrid polypyrrole nanoparticles as a conducting polymer with controllable size
Authors: Mahmood Javeed , Arsalani Nasser , Naghash-Hamed Samin , Hanif Zahid , Geckeler Kurt E. 
Published: May 2024

AbstractHybrid polypyrrole (PPy) nanoparticles were prepared using a low-temperature oxidative polymerization process in an acidic solution with polyethyleneimine (PEI) as a template and amine source. The results showed that the nanoparticles have an amorphous structure in the X-ray diffractogram and exhibited good dispersibility in water, uniform size, and a specific conductivity ranging from 0.1 to 6.9 S/cm. The particle size could be tuned from 85 to 300 nm by varying the reactant concentration. Undoping the samples with sodium hydroxide (NaOH) solution altered the optical absorption properties and surface roughness of the particles. However, it did not affect the particle size. The nanoparticles also exhibited optical sensing properties based on their UV–vis absorption changes with the pH. Moreover, nanoparticles could have potential applications in gene delivery and bio-adsorption for contaminant removal. This work demonstrates a simple and effective method for preparing hybrid polypyrrole nanoparticles with controllable size, dispersibility, and conductivity for various nanotechnology, biotechnology, and environmental engineering purposes.