bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Nasolacrimal SCC Treatments and Promising Role of Chemo‐Induction: A Case Report and Systematic Review
Authors: Alsavaf Mohammad Bilal , Abouammo Moataz D. , Bhuskute Govind S. , Sun Shuai , Issa Majd , Seim Nolan B. , VanKoevering Kyle K. , Bhateja Priyanka , Bonomi Marcelo , Carrau Ricardo L. 
Published: April 2024

ObjectiveTo comprehensively analyze reported cases of nasolacrimal squamous cell carcinoma (NLSCC), focusing on risk factors, treatment modalities, and outcomes. Additionally, investigate the impact of human Papillomavirus (HPV) status and histopathological subtypes' impact on prognosis.Data SourcesPubmed, Embase.Review MethodsWe conducted a systematic literature review to identify relevant studies reporting cases of NLSCC. The review methods adhered to Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines. The final update was performed on May 31, 2023.ResultsThe 72 studies included a total of 313 participants (mean age: 55; 60% male). Longer symptom duration (44.1 ± 59.2 months) correlated with recurrence (p = 0.004), and males exhibited higher mortality rates (19.6% vs. 2.4% in females, p = 0.01). The overall survival (OS) rate among all patients was 87.1%. Basaloid NLSCC had a worse death outcome (p ≤ 0.001). HPV‐positive cases showed comparable OS, recurrence, and metastasis rates to the general population (p = 0.917, 0.851, 0.07, respectively). Comparing treatment approaches (surgery, surgery with adjuvant radiation, chemoradiotherapy [CRT] followed by surgery), no significant differences in 5 and 10‐year OS rates or recurrence were observed (p = 0.4, 0.24, respectively), but 5‐year metastasis events were significant (p = 0.024). Eye exenteration rates were 31.1%, 20%, and 0% for the respective treatments (p = 0.089). Induction chemotherapy saved four cases from potential exenteration with favorable prognosis.ConclusionEarly detection and diagnosis are of utmost importance in the management of NLSCC. Regardless of the treatment approach, HPV‐related NLSCC demonstrated similar outcomes to the general population. Basaloid histology represents the worst subtype in terms of prognosis. Limited adjuvant CRT cases showed improved outcomes and induction chemotherapy's importance was emphasized in recent literature and our shared experience. Laryngoscope, 134:3892–3902, 2024
Length of Stay Prediction Models for Oral Cancer Surgery: Machine Learning, Statistical and ACS‐NSQIP
Authors: Namavarian Amirpouyan , Gabinet‐Equihua Alexander , Deng Yangqing , Khalid Shuja , Ziai Hedyeh , Deutsch Konrado , Huang Jingyue , Gilbert Ralph W. , Goldstein David P. , Yao Christopher M.K.L. , Irish Jonathan C. , Enepekides Danny J. , Higgins Kevin M. , Rudzicz Frank , Eskander Antoine , Xu Wei , de Almeida John R. 
Published: April 2024

ObjectiveAccurate prediction of hospital length of stay (LOS) following surgical management of oral cavity cancer (OCC) may be associated with improved patient counseling, hospital resource utilization and cost. The objective of this study was to compare the performance of statistical models, a machine learning (ML) model, and The American College of Surgeons National Surgical Quality Improvement Program's (ACS‐NSQIP) calculator in predicting LOS following surgery for OCC.Materials and MethodsA retrospective multicenter database study was performed at two major academic head and neck cancer centers. Patients with OCC who underwent major free flap reconstructive surgery between January 2008 and June 2019 surgery were selected. Data were pooled and split into training and validation datasets. Statistical and ML models were developed, and performance was evaluated by comparing predicted and actual LOS using correlation coefficient values and percent accuracy.ResultsTotally 837 patients were selected with mean patient age being 62.5 ± 11.7 [SD] years and 67% being male. The ML model demonstrated the best accuracy (validation correlation 0.48, 4‐day accuracy 70%), compared with the statistical models: multivariate analysis (0.45, 67%) and least absolute shrinkage and selection operator (0.42, 70%). All were superior to the ACS‐NSQIP calculator's performance (0.23, 59%).ConclusionWe developed statistical and ML models that predicted LOS following major free flap reconstructive surgery for OCC. Our models demonstrated superior predictive performance to the ACS‐NSQIP calculator. The ML model identified several novel predictors of LOS. These models must be validated in other institutions before being used in clinical practice.Level of Evidence3 Laryngoscope, 134:3664–3672, 2024
NKAIN1, as an oncogene, promotes the proliferation and metastasis of breast cancer, affecting its prognosis
Authors: Wang XiMei , Yang FangZheng , Sun Zhi , Zhao GuangHui , Pu Qian , Geng ChenChen , Dong Ke , Zhang XiaoDong , Liu ZiQian , Song HaiYun 
Published: April 2024

AbstractNa, K‐ATPase interaction (NKAIN) is a transmembrane protein family, which can interact with Na, K‐ATPase β1 subunit. NKAIN1 plays an important role in alcohol‐dependent diseases such as endometrial and prostate cancers. However, the relationship between NKAIN1 and human breast cancer has not been studied. Hence, this study aimed to explore the relationship between NKAIN1 expression and breast cancer. Data used in this study were mainly from the Cancer Genome Atlas, including differential expression analysis, Kaplan–Meier survival analysis, receiver operating characteristic curve analysis, multiple Cox regression analysis, co‐expression gene analysis, and gene set enrichment analysis. Analyses were performed using reverse transcription‐quantitative polymerase chain reaction, western blot analysis, and immunohistochemistry on 46 collected samples. The knockdown or overexpression of NKAIN1 in vitro in MCF‐7 and MDA‐MB‐231 cell lines altered the proliferation and migration abilities of tumor cells. In vivo experiments further confirmed that NKAIN1 knockdown effectively inhibited the proliferation and migration of cancer cells. Therefore, our study identified NKAIN1 as an oncogene that is highly expressed in breast cancer tissues. The findings highlight the potential of NKAIN1 as a molecular biomarker of breast cancer.
B1 inhomogeneity corrected CEST MRI based on direct saturation removed omega plot model at 5T
Authors: Wu Qiting , Gong Pengcheng , Liu Shengping , Li Ye , Liang Dong , Zheng Hairong , Wu Yin 
Published: April 2024

AbstractPurposeCEST can image macromolecules/compounds via detecting chemical exchange between labile protons and bulk water. B1 field inhomogeneity impairs CEST quantification. Conventional B1 inhomogeneity correction methods depend on interpolation algorithms, B1 choices, acquisition number or calibration curves, making reliable correction challenging. This study proposed a novel B1 inhomogeneity correction method based on a direct saturation (DS) removed omega plot model.MethodsFour healthy volunteers underwent B1 field mapping and CEST imaging under four nominal B1 levels of 0.75, 1.0, 1.5, and 2.0 μT at 5T. DS was resolved using a multi‐pool Lorentzian model and removed from respective Z spectrum. Residual spectral signals were used to construct the omega plot as a linear function of 1/, from which corrected signals at nominal B1 levels were calculated. Routine asymmetry analysis was conducted to quantify amide proton transfer (APT) effect. Its distribution across white matter was compared before and after B1 inhomogeneity correction and also with the conventional interpolation approach.ResultsB1 inhomogeneity yielded conspicuous artifact on APT images. Such artifact was mitigated by the proposed method. Homogeneous APT maps were shown with SD consistently smaller than that before B1 inhomogeneity correction and the interpolation method. Moreover, B1 inhomogeneity correction from two and four CEST acquisitions yielded similar results, superior over the interpolation method that derived inconsistent APT contrasts among different B1 choices.ConclusionThe proposed method enables reliable B1 inhomogeneity correction from at least two CEST acquisitions, providing an effective way to improve quantitative CEST MRI.
Mapping artificial drains in peatlands—A national‐scale assessment of Irish raised bogs using sub‐meter aerial imagery and deep learning methods
Authors: Habib Wahaj , Cresson Rémi , McGuinness Kevin , Connolly John 
Published: April 2024

AbstractPeatlands, constituting over half of terrestrial wetland ecosystems across the globe, hold critical ecological significance and are large stores of carbon (C). Irish oceanic raised bogs are a rare peatland ecosystem offering numerous ecosystem services, including C storage, biodiversity support and water regulation. However, they have been degraded over the centuries due to artificial drainage, followed by peat extraction, afforestation and agriculture. This has an overall negative impact on the functioning of peatlands, shifting them from a moderate C sink to a large C source. Recognizing the importance of these ecosystems, efforts are underway for conservation (rewetting and rehabilitation), while accurately accounting for C stock and greenhouse gas (GHG) emissions. However, the implementation of these efforts requires accurate identification and mapping of artificial drainage ditches. This study utilized very high‐resolution (25 cm) aerial imagery, and a deep learning (U‐Net) approach to map the visible artificial drainage (unobstructed by vegetation or infill) in raised bogs at a national scale. The results show that artificial drainage is widespread, with ~20 000 km of drains mapped. The overall accuracy of the model was 80% on an independent testing dataset. The data were also used to derive the Fracditch which was 0.03 (fraction of artificial drainage on industrial peat extraction sites). This is lower than IPCC Tier 1 Fracditch and can aid in IPCC Tier 2 reporting for Ireland. This is the first study to map drains with diverse sizes and patterns on Irish‐raised bogs using optical aerial imagery and deep learning methods. The map will serve as an important baseline dataset for evaluating the artificial drainage ditch conditions. It will prove useful for sustainable management, conservation and refined estimations of GHG emissions. The model's capacity for generalization implies its potential in mapping artificial drains in peatlands at a regional and global scale, thereby enhancing the comprehension of the global effects of artificial drainage ditches on peatlands.
Viticulture and the European Union's Common Agricultural Policy (CAP): Historical overview, current situation and future perspective
Authors: Homet Pablo , Gallardo‐Reina Manuel Ángel , Aguiar Juan F. , Liberal Isabel M. , Casimiro‐Soriguer Ramón , Ochoa‐Hueso Raúl 
Published: April 2024

AbstractThe grapevine is one of the most important perennial fruit crops worldwide. The historical stability of winegrowing methods has spanned almost 3000 years since the introduction of viticulture in Europe. However, in the last 70 years, the wine sector in the Europe has experienced substantial transformations. These changes are attributed to the widespread adoption of mechanisation and industralisation in the 1950s and the establishment of the Common Agricultural Policy (CAP). The growing concern for the environment and climate change in the European Union (EU) has significantly influenced the successive reforms of the CAP. These reforms have resulted in the acquisition of new commitments to protect the environment, mitigate climate change and reduce biodiversity loss over the years. In this work, we carried out a critical analysis of the most relevant aspects of the new CAP and address the regulatory framework of organic agriculture in the EU as a tool for improving the sustainability of vineyards. Currently, Spain is the country with the largest vineyard area in the world, reaching 964,000 hectares. This represents 13% of the world's vineyards and 30% in the EU, which demonstrates the importance of this crop in Europe. Due to its relevance, we focused our critical analyses of the new CAP on Spain as a case study. The latest reform of the CAP, applicable for the period 2023‐2027, is the most ambitious in environmental terms and includes instruments such as reinforced conditionality, eco‐schemes and payments for agri‐environment–climate commitments. Finally, we propose that by integrating concepts and management strategies from current organic and regenerative viticulture together with historical strategies derived from treatises and classic authors across a wide range of societies and cultures, the goals of the new CAP can be successfully met. This will contribute to reuniting the past, the present and the future of viticulture for a more nature‐based winemaking.
Residential exposure to environmental nuisances in Cameroon
Authors: Totouom Armand , Ngameni Joseph Pasky , Fassi Poumeni Rosine 
Published: April 2024

AbstractThe objective of this study is to analyze the determinants of perceived residential exposure to environmental nuisances in Cameroon. The ordered logit model specified in our empirical analysis is estimated using data from the Fourth Cameroon Household Survey. Our findings suggest that perceived residential exposure to environmental nuisance is inversely related to home ownership and having a fence around home. Conversely, it is related to both internal household factors such as the use of kerosene for cooking and external factors such as the pavement of the road leading to housing and the proximity to transport infrastructure. For example, the use of kerosene for cooking is associated with a 0.025 point increase in the probability of being occasionally bothered by odor nuisance and a 0.036 point decrease in the probability of never being annoyed by odor nuisance. Similarly, the pavement of the road leading to housing and proximity to transport infrastructure are associated with a respective 0.121 and 0.170 points increase in the probability of being frequently bothered by noise pollution. Various relevant policy recommendations were proposed among which, the implementation of effective urban planning and transport systems to accompany urban expansion as well as the subsidies to ease access to improved stoves.
Unravelling the Design and Mechanism: Potential of Substituted Quinolines as PASTA subunit 4 Inhibitors for Antimicrobial Activity
Authors: Sharma Kirti , Sharma Atul , Sanduja Mohit , Kumar Asim 
Published: April 2024

AbstractThe increasing incidences of antibiotic‐resistance in Microorganisms have become a critical global health challenge. Traditional treatments, often relying on multiple antibiotics, are plagued by issues like drug resistance, reduced effectiveness, and heightened toxicity. In response, there is a compelling demand for innovative anti‐microbial agents that offer novel mechanisms of action. The family of bacterial Penicillin‐binding protein And Serine/Threonine kinase‐Associated (PASTA) kinases is of particular interest due to the role of these kinases in regulating resistance to ‐lactam antibiotics. As such, small molecule kinase inhibitors that target PASTA kinases may prove beneficial as treatments adjunctive to ‐lactam therapy. Our study was primarily geared towards identifying novel PASTA Kinase inhibitors through a ligand‐based drug design approach. Subsequently, we curated a library of 12 molecules, incorporating chemical modifications guided by considerations like drug‐like properties, chemical accessibility, and synthetic feasibility. Molecular docking analyses conducted on this library pinpointed three molecules with noteworthy binding affinities. From this subset, KS_QD_04 and KS_QD_05 emerged as promising candidates, subsequently validated through MD simulation studies, bolstering their potential as lead compounds in the quest to develop PASTA Kinase inhibitors for combating raising microbial resistance towards antibiotics.
2‐(1‐Methyl‐1H‐indazol‐5‐yl)‐N‐arylisonicotinamide Analogs: Synthesis, Anticancer Screening, SAR and ADMET Studies
Authors: Patel Umang P. , Unjiya Parth S. , Dabhi Ranjitsinh C. , Parmar Hemal M. , Shah Manish K. 
Published: April 2024

AbstractIn this current research framework, we detailed the synthesis of ten novel 2‐(1‐methyl‐1H‐indazol‐5‐yl)‐N‐arylisonicotinamide analogs (3a–j). The synthesis of these compounds (3a–j) involved a three‐step process, employing the Suzuki‐Miyaura coupling reaction, which successfully linked 1‐methyl‐1H‐indazole with isonicotinamide to satisfactory yields. The synthesized compounds were characterized using various spectroscopic techniques. To assess their potential, the anticancer activity of compounds (3a–j) was evaluated following the National Cancer Institute (NCI US) protocol against nine panels comprising different cancer cell lines, at a concentration of 10−5 M. Growth percentage (GP) and percentage growth inhibition (PGI) were calculated for each compound. Notably, the CNS cancer cell line SNB‐75 exhibited a remarkable PGI of 99.16 percent, indicating high sensitivity to the tested compound 3e. Additionally, ADMET prediction suggested that most of the synthesized compounds possess drug‐like properties, with low adverse effects and toxicity. These findings represent a significant advancement, offering potential avenues for further developments in the field of cancer research.
Building project resilience: A critical systems practice approach
Authors: Zarghami Seyed Ashkan , Zwikael Ofer 
Published: April 2024

AbstractConsisting of multifaceted interactions between various human and non‐human actors, projects are prime illustrations of complex systems. Such complexity amplifies the negative effect of disruptive events—common in projects owing to their high level of uncertainty. Therefore, building project resilience to provide a quick recovery process with minimal adverse consequences is of critical importance. However, literature lacks an effective framework for such. This paper argues that methodological pluralism is necessary for solving complex practical problem situations, based on the view of Mike C. Jackson—a seminal figure in the field of systems thinking. Accordingly, this paper takes a critical systems practice (CSP) approach to develop a framework for building resilience in projects. The application of the proposed framework is illustrated through a case of supply shortages in the automotive industry. The results underscore the significance of portraying a comprehensive view of both human and non‐human contributors to projects, surpassing conventional project‐driven management methods, which rely on science and experimentation. Additionally, the study emphasises how CSP, as an ideal type of multimethodological practice, broadens our perspective by offering insights into the multidimensional characteristics of resilience.
A global evaluation of urban agriculture potential for pollinator‐dependent crops in major cities
Authors: Rahimi Ehsan , Jung Chuleui 
Published: April 2024

AbstractRecent research is increasingly focusing on the significance of urban gardens, urban agriculture, and rooftop agriculture as viable solutions to address food security issues. The crops cultivated in these urban settings play a crucial role in promoting urban sustainability. However, a considerable number of these crops rely on pollinators, making them key contributors to global food security, especially concerning micronutrient content. Therefore, a pivotal step in the urban planning process for local food production involves estimating the potential and available area for urban agriculture. In this study, we employed species distribution models (SDMs) to globally assess major cities' suitability for urban agriculture. Through the creation of habitat suitability maps for 61 pollinator‐dependent crops using SDMs, we evaluated the potential of 1143 major cities worldwide to cultivate each of these crops. Our findings reveal that nearly half of the examined cities (570) can support 0–10 crops, with approximately 30% (353 cities) able to sustain 11–20 crops. Around 14.5% of the cities are deemed suitable for supporting 21–30 crops. However, only about 4.5% of cities can accommodate between 31 and 40 crops. Across all 1143 cities studied, it was determined that each city, on average, has the potential to support 12.5 crops. This represents approximately 20% of the total percentage of pollinator‐dependent crops (61 crops) considered in this comprehensive analysis. While our research offers valuable insights into the potential of urban agriculture, researchers and urban planners must approach these findings with caution, particularly when extrapolating to regions with limited crop occurrence data. Additionally, we underscore the significance of understanding the distribution patterns of pollinators, especially bees, in urban environments. Relying solely on climatic variables to assess crop suitability in urban areas may be restrictive, considering the vital role of pollinators in crop production.
Antimicrobial effects of laurel extract, laurel essential oil, zahter extract, and zahter essential oil on chicken wings contaminated with Salmonella Typhimurium
Authors: Yilmaz Ezgi Ayan , Yalçin Halil , Polat Zübeyde 
Published: April 2024

AbstractBackgroundThis study aimed to evaluate the antimicrobial effects of zahter extract, zahter essential oil, laurel extract, and laurel essential oil on Salmonella Typhimurium inoculated on chicken wings.MethodsA total of 10 groups, including eight study groups and two control groups were formed, consisting of zahter extract and zahter essential oil and laurel extract and laurel essential oil in different proportions. In the study, laurel extract at 6.4% and 12.8% concentrations, laurel essential oil at 0.2% and 0.4% concentrations, zahter extract at 0.2% and 0.4% concentrations, and zahter essential oil at 0.2% and 0.4% concentrations were used.ResultsThe broth microdilution method was used to evaluate the antimicrobial activity of the extract and essential oils on the S. Typhimurium. Minimum inhibitory concentrations of the extracts and essential oils used in the study against S. Typhimurium were determined. The highest inhibitory effect on S. Typhimurium was observed in the 0.4% laurel essential oil group. It was determined that the inhibitory effect increased as the concentration of laurel essential oil increased. In addition, the antimicrobial activity of zahter essential oil is less inhibitory than the laurel extract, laurel essential oil, and zahter extract.ConclusionAccording to the results of this study, it has been revealed that extracts and essential oils obtained from zahter and laurel plants, which have been shown to be natural antimicrobial, can be used in foods as an alternative to chemical additives. To develop research results, the applicability of these extracts and essential oils in different foodstuffs should be examined using different ingredients and concentrations.