bluuebunny/crossref_metadata_2025_split huggingface dataset:
Idiopathic dendriform pulmonary ossification as the phenotype of interstitial lung abnormalities: CT–pathologic correlation and prevalence
Authors: Ueno Midori , Egashira Ryoko , Hashisako Mikiko , Fujimoto Kiminori , Fukuda Taiki , Hayashida Yoshiko , Sumikawa Hiromitsu , Tominaga Junya , Tanaka Tomonori , Terasaki Yasuhiro , Fukuoka Junya , Nishioka Yasuhiko , Aoki Takatoshi , Gabata Toshifumi , Hatabu Hiroto , Johkoh Takeshi 
Published: May 2024

Abstract
Background and purpose
Idiopathic dendriform pulmonary ossification (DPO) is mostly asymptomatic, and detected incidentally in lung CT. There have been no reports on the precise CT–pathologic correlation and the prevalence of idiopathic DPO. This study aimed to clarify the histological background and prevalence of idiopathic DPO.

Materials and methods
Sixteen patients with histologically confirmed idiopathic DPO (12 men and 4 women; mean age, 38.8 years; range 22–56 years) were identified in a nationwide epidemiological survey. Local HRCT findings of pre-biopsy examinations, such as branching, round, linear structures with or without high attenuation were compared side by side with histological findings. The attenuation of branching, round, and linear structures was classified into three-point levels on bone window images (width, 2500 HU; level, 500 HU). Furthermore, we collected continuous pulmonary CT images of 8111 cases for checking up metastasis from extrathoracic malignancy at a single institution, and evaluated the prevalence of interstitial lung abnormalities (ILAs) and DPO.

Results
In all 16 cases, branching (n = 15, 93%), round (n = 5, 31%), or linear (n = 5, 31%) structures were identified, histologically corresponding to dendriform ossification and cicatricial organizing pneumonia (OP)/fibrosis. Histologically, ossification was confirmed in all the 16 patients. However, in two cases, a highly attenuated structure could not be detected on the pre-biopsy CT of the same area. Regarding the prevalence of idiopathic DPO, 283 (3.5%) of 8111 patients had ILAs, of which a total of 26 (0.3% of all cases, 9.2% of ILAs cases) had DPO.

Conclusion
Idiopathic DPO showed linear or branching structures with or without high attenuation on CT, corresponded to ossification, cicatricial OP/fibrosis. DPO was seen in 9.2% of ILAs cases. Idiopathic DPO is one of pathologic phenotypes of ILAs.
Cured but not well — haematological cancer survivors’ experiences of chemotherapy-induced peripheral neuropathy in everyday life: a phenomenological-hermeneutic study
Authors: Roed Mette Louise , Severinsen Marianne Tang , Maksten Eva Futtrup , Jørgensen Lone , Enggaard Helle 
Published: May 2024

Abstract
Purpose
To explore haematological cancer survivors’ experience of chemotherapy-induced peripheral neuropathy (CIPN) in everyday life.

Methods
Data were generated by means of individual semi-structured interviews with 12 haematological cancer survivors who experience CIPN after completion of treatment. Data were analysed using thematic analysis.

Results
The thematic analysis yielded an in-depth description of the experience of CIPN symptoms and the influence of the symptoms on everyday life as being unwell despite being cured. Four main themes emerged from the analysis: (1) A diffuse and contradictory sensation which is impossible to ignore in everyday life, (2) Not feeling well, even though I’m cured, (3) Living with CIPN, despite limitations, and (4) An invisible companion, that everybody knows about.

Conclusion
The findings shows that survival from haematological cancer does not always equal well-being, as experiencing CIPN has extensive consequences on everyday life. CIPN affects haematological cancer survivors’ transition to an ordinary everyday life, with disturbances in the physical function, daily activities, social relationships, psychological aspects, and work ability. As a diffuse and contradictory symptom, CIPN appears as an invisible companion that leads to a feeling of being alone.

Implications for Cancer Survivors
A better and deeper understanding of haematological cancer survivors’ experience of CIPN in everyday life may improve communication, guidance, and treatment of CIPN symptoms. The results suggest a need for interventions and strategies to accommodate the gap in practice and to address the impact of CIPN in everyday life.
Who uses connected health technologies after a cancer diagnosis? evidence from the US Health Information National Trends Survey
Authors: Gitonga Isaiah , Desmond Deirdre , Maguire Rebecca 
Published: May 2024

Abstract
Purpose
As the number of people living with and beyond cancer increases, connected health technologies offer promise to enhance access to care and support, while reducing costs. However, uptake of connected health technologies may vary depending on sociodemographic and health-related variables. This study aimed to investigate demographic and health predictors of connected health technology use among people living with and beyond cancer.

Methods
Cross-sectional data from the US Health Information National Trends Survey Version 5 Cycle 4 (H5c4) was used. Regression analysis was used to examine associations between sociodemographic factors and the use of connected health technologies. The sample was restricted to individuals who self-reported a cancer diagnosis or history of cancer.

Results
In this cycle, 626 respondents self-reported a cancer diagnosis, with 41.1% using connected health technologies (health and wellness apps and/or wearable devices). Most were female (58.9%) and white (82.5%); 43.4% had graduated college or higher education. One third (33.6%) had a household income of $75,000 or more. Respondents who were younger, have higher education, were living as married, had higher incomes, had higher self-rated health and had higher health-related self-efficacy were significantly more likely to use connected health technologies. There were no significant associations between gender, race, stratum, time since diagnosis, history of anxiety or depression, and use of connected health technologies among people living with and beyond cancer.

Conclusions
Connected health technology use among people living with and beyond cancer is associated with sociodemographic factors. Future research should examine these demographic disparities as the use of connected health technologies in healthcare continues to gather momentum.

Implications for cancer survivors
The study underscores a disparity in connected heath technology usage among people living with and beyond cancer. There is a pressing need for research into adoption barriers and interventions to ensure equitable digital healthcare integration among this population, especially with the heightened adoption of technology post COVID-19 pandemic.
MicroRNA-451 Regulates Angiogenesis in Intracerebral Hemorrhage by Targeting Macrophage Migration Inhibitory Factor
Authors: Bai Shuang , Zhang Ge , Chen Shiling , Wu Xuan , Li Jiarui , Wang Jingxuan , Chen Danyang , Liu Xia , Wang Jiahui , Li Yuanwei , Tang Yingxin , Tang Zhouping 
Published: May 2024

AbstractIntracerebral hemorrhage (ICH) is a subtype of stroke with the highest fatality and disability rate. Up to now, commonly used first-line therapies have limited value in improving prognosis. Angiogenesis is essential to neurological recovery after ICH. Recent studies have shown that microRNA-451(miR-451) plays an important role in angiogenesis by regulating the function of vascular endothelial cells. We found miR-451 was significantly decreased in the peripheral blood of ICH patients in the acute stage. Based on the clinical findings, we conducted this study to investigate the potential regulatory effect of miR-451 on angiogenesis after ICH. The expression of miR-451 in ICH mouse model and in a hemin toxicity model of human brain microvascular endothelial cells (hBMECs) was decreased the same as in ICH patients. MiR-451 negatively regulated the proliferation, migration, and tube formation of hBMECs in vitro. MiR-451 negatively regulated the microvessel density in the perihematoma tissue and affected neural functional recovery of ICH mouse model. Knockdown of miR-451 could recovered tight junction and protect the integrity of blood-brain barrier after ICH. Based on bioinformatic programs, macrophage migration inhibitory factor (MIF) was predicted to be the target gene and identified to be regulated by miR-451 inhibiting the protein translation. And p-AKT and p-ERK were verified to be downstream of MIF in angiogenesis. These results all suggest that miR-451 will be a potential target for regulating angiogenesis in ICH.
Helicopter parenting, autonomy support, and young adults’ psychological adjustment in Turkey: the mediating role of psychological control
Authors: Alsancak-Akbulut Cansu , Kömürcü-Akik Burcu 
Published: May 2024

AbstractThis study examined the relations from helicopter parenting and autonomy-supportive parenting to Turkish emerging adults’ psychological adjustment (depression, anxiety, and stress levels), using parental psychological control as a mediating mechanism. The participants included 457 emerging adults aged between 17 and 27 (M = 20.47, SD = 1.90) who filled out a self-report questionnaire on their parents’ helicopter parenting, autonomy-supportive parenting, psychological control, and their depression, anxiety, and stress levels. Path analyses were performed to test the hypotheses. The findings displayed that there were indirect links from helicopter parenting and autonomy-supportive parenting to emerging adults’ psychological adjustment through parental psychological control in a relatively collectivistic Turkish cultural context. Results indicated that parents who engage in developmentally inappropriate over-involvement in their children’s lives may also use psychological control to maintain or strengthen their control over their children. Furthermore, parents’ autonomy support may be related to a decrease in their tendency to use psychological control, which in turn results in better psychological adjustment.
Who does Neuroethics Scholarship Address, and What Does it Recommend? A Content Analysis of Selected Abstracts from the International Neuroethics Society Annual Meetings
Authors: Wei Nina Yichen , Choi Rebekah J. , Sullivan Laura Specker , Wexler Anna 
Published: May 2024

AbstractMuch neuroethics literature concludes with a set of normative recommendations. While these recommendations can be a helpful way of summarizing a proposal for a future direction, some have recently argued that ethics scholarship has devoted insufficient attention to considerations of audience and real-world applications. To date, however, while scholars have conducted topic analyses of neuroethics literature, to our knowledge no study has evaluated who neuroethics scholarship addresses and what it recommends. The objective of the present study therefore was to provide a preliminary characterization of recommendations offered in neuroethics scholarship and an assessment of their target audiences. Rather than attempting to demarcate what constitutes “neuroethics scholarship,” we analyzed text that authors’ had self-identified as being neuroethics-related: abstracts presented at the International Neuroethics Society (INS) annual meetings and published as top abstracts in AJOB Neuroscience in the last decade (2011–2020). We found that a majority of abstracts utilized conceptual methods (62.2%) and provided conceptual recommendations (68%). Roughly 77% of all abstracts did not explicitly address a target audience, yet nearly all of these were implicitly directed at other scholars. The remainder specified a target audience of scholars (12.2%), regulators (6.7%), healthcare providers (6.7%) and industry (2.6%). Only a subset of abstracts provided practical or policy recommendations (19.7%). Of those, the majority (61.5%) did not specify a target audience. Among the subset with actionable recommendations, a clarification of target audience may help increase the impact.
Does Mindfulness Decrease or Increase Egoic Functioning? Diverging Evidence From Different Study Designs
Authors: Nyklíček Ivan , Ostafin Brian D. , Boekhorst Myrthe G. B. M. 
Published: May 2024

Abstract
Objectives
Mindfulness meditation has been claimed to decrease aspects of egoic functioning (EF). However, empirical evidence is largely lacking or is suggesting the reverse. Therefore, the aim was to examine the associations between mindfulness, mindfulness interventions, egoic functioning, and emotional well-being using different designs.

Method
We conducted three studies: (i) a cross-sectional study in the general population (n = 796), (ii) an experiment in a student population (n = 84) where we manipulated mindfulness meditation, and (iii) an intervention in self-enrolled individuals from the general population receiving a standard 8-week Mindfulness-Based Stress Reduction (MBSR) program (n = 165).

Results
In the cross-sectional study, most mindfulness facets showed positive (mainly with self-enhancement) or nonsignificant associations with facets of EF. In the experiment, participants in the mindfulness meditation (vs. control) condition exhibited lower self-enhancement of positive characteristics. In the intervention, some aspects of EF decreased (e.g. demanding control), whereas some increased (e.g. refusal to comply) after MBSR, and these changes correlated meaningfully with changes in self-reported mindfulness and well-being.

Conclusions
The results suggest that aspects of EF are differentially associated with aspects of self-reported mindfulness and differentially respond to a brief mindfulness manipulation and an 8-week MBSR intervention. We formulated two dimensions on which various relevant self-concept constructs may be positioned: competition-based versus compassion-based.

Preregistration
The studies are not preregistered.
Harnessing exosomes in theranostic applications: advancements and insights in gastrointestinal cancer research
Authors: Shojaeian Ali , Naeimi Torshizi S. R. , Parsapasand Mahsa Sadat , Amjad Zahra Sobhi , Khezrian Ali , Alibakhshi Abbas , Yun Faye , Baghaei Kaveh , Amini Razieh , Pecic Stevan 
Published: May 2024

AbstractExosomes are small extracellular vesicles (30–150 nm) that are formed by endocytosis containing complex RNA as well as protein structures and are vital in intercellular communication and can be used in gene therapy and drug delivery. According to the cell sources of origin and the environmental conditions they are exposed to, these nanovesicles are very heterogeneous and dynamic in terms of content (cargo), size and membrane composition. Exosomes are released under physiological and pathological conditions and influence the pathogenesis of cancers through various mechanisms, including angiogenesis, metastasis, immune dysregulation, drug resistance, and tumor growth/development. Gastrointestinal cancer is one of the deadliest types of cancer in humans and can involve organs e.g., the esophagus and stomach, or others such as the liver, pancreas, small intestine, and colon. Early diagnosis is very important in this field because the overall survival of patients is low due to diagnosis in late stages and recurrence. Also, various therapeutic strategies have failed and there is an unmet need for the new therapeutic agents. Exosomes can become promising candidates in gastrointestinal cancers as biomarkers and therapeutic agents due to their lower immunity and passing the main physiological barriers. In this work, we provide a general overview of exosomes, their biogenesis and biological functions. In addition, we discuss the potential of exosomes to serve as biomarkers, agents in cancer treatment, drug delivery systems, and effective vaccines in immunotherapy, with an emphasis on gastrointestinal cancers.
Graphical Abstract
Interventional therapy combined with tyrosine kinase inhibitors with or without immune checkpoint inhibitors as initial treatment for hepatocellular carcinoma with portal vein tumor thrombosis: a systematic review and meta-analysis
Authors: Du Changjie , Wu Hongyu , Zhong Tao , Zhai Qilong , Yuan Jiajun , Peng Jialun , Ma Rong , Li Jinzheng 
Published: May 2024

Abstract
Background
Interventional therapy, in conjunction with tyrosine kinase inhibitors (TKIs), has shown promising outcomes for treating hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT). With the advent of immunotherapy, the combined use of immune checkpoint inhibitors (ICIs) has attracted great attention due to their potential effectiveness in advanced HCC. This study aims to compare the efficacy and safety of a triple therapy regimen (Interventional therapy, TKIs and ICIs, IT-TKI-ICI) with a dual therapy regimen (Interventional therapy and TKIs, IT-TKI) in the treatment of HCC and PVTT (HCC-PVTT).

Methods
A comprehensive search was carried out in PubMed, Web of Science, Embase, Scopus, and the Cochrane Library databases. Primary outcome measures were overall survival (OS) and progression-free survival (PFS), while secondary outcomes included tumor response rate, adverse event incidence as well as downstaging surgery rate. Statistical analysis was conducted using Revman 5.4 software.

Results
The meta-analysis finally included 6 cohort studies. The triple therapy group demonstrated significantly prolonged OS and PFS compared to the dual therapy group. Meanwhile, the former exhibited significantly higher rates of objective response rate (ORR), disease control rate (DCR) and better downstaging effects with a higher salvage surgery rate without significantly increasing adverse events.

Conclusion
In comparison to dual therapy, the triple therapy with interventional therapy, TKIs, and ICIs demonstrates superior efficacy and equivalent safety for HCC-PVTT.
Hydroxymethylation hydroxylation of 1,3-diarylpropene through a catalytic diastereoselective Prins reaction: cyclization logic and access to brazilin core
Authors: Hu Xin-Ting , Cheng Qing-Yan , Chen Yan-Ping , Li Kun , Yan Cai-Xian , Li Dashan , Shao Li-Dong 
Published: May 2024

AbstractA catalytic diastereoselective Prins reaction for hydroxymethylation and hydroxylation of 1,3-diarylpropene was successfully utilized to prepare various 1,3-dioxanes 7 in 14–88% yields. Take advantage of the synthetic intermediate 7h, the key B/C rings in brazilin core could be constructed by the sequential of Friedel–Crafts/Ullmann-Ma rather than Ullmann-Ma/Friedel–Crafts reactions.
Graphical Abstract
Comparative metabolite analysis of Piper sarmentosum organs approached by LC–MS-based metabolic profiling
Authors: Ware Ismail , Franke Katrin , Frolov Andrej , Bureiko Kseniia , Kysil Elana , Yahayu Maizatulakmal , El Enshasy Hesham Ali , Wessjohann Ludger A. 
Published: May 2024

AbstractPiper sarmentosum Roxb. (Piperaceae) is a traditional medicinal and food plant widely distributed in the tropical and subtropical regions of Asia, offering both health and culinary benefits. In this study the secondary metabolites in different organs of P. sarmentosum were identified and their relative abundances were characterized. The metabolic profiles of leaves, roots, stems and fruits were comprehensively investigated by liquid chromatography high-resolution mass spectrometry (LC-HR-MS) and the data subsequently analyzed using multivariate statistical methods. Manual interpretation of the tandem mass spectrometric (MS/MS) fragmentation patterns revealed the presence of 154 tentatively identified metabolites, mostly represented by alkaloids and flavonoids. Principle component analysis and hierarchical clustering indicated the predominant occurrence of flavonoids, lignans and phenyl propanoids in leaves, aporphines in stems, piperamides in fruits and lignan-amides in roots. Overall, this study provides extensive data on the metabolite composition of P. sarmentosum, supplying useful information for bioactive compounds discovery and patterns of their preferential biosynthesis or storage in specific organs. This can be used to optimize production and harvesting as well as to maximize the plant’s economic value as herbal medicine or in food applications.
Graphical Abstract
Parent-Mediated Play-Based Interventions to Improve Social Communication and Language Skills of Preschool Autistic Children: A Systematic Review and Meta-analysis
Authors: Deniz Emre , Francis Gill , Torgerson Carole , Toseeb Umar 
Published: May 2024

AbstractPlay-based interventions are gaining popularity amongst autistic children. Parents are uniquely placed to deliver these interventions as they are most familiar with their child’s strengths and challenges. Accordingly, reporting the effectiveness of play-based interventions and/or parent-delivered or mediated early-year interventions have been popular topics in the literature in the last decade. Despite this, little is known about the efficacy of parent-mediated play-based interventions on the developmental outcomes of autistic children. To close this gap in knowledge, we conducted a systematic review and meta-analysis of randomised controlled trials and quasi-experiments focusing on social communication skills, language skills, and autistic characteristics of preschool autistic children (0–6-year-old) in non-educational settings. Overall, 26 studies met the inclusion criteria 21 of which were included in the synthesis. Of the included studies, 20 studies reported social communication skills, 15 studies reported language skills, and 12 studies reported autistic characteristics. Pooling effect sizes across the included studies showed that parent-mediated play-based interventions were effective on social communication (d =  .63) and language skills (d =  .40) as well as autistic characteristics (d =   − .19) of preschool autistic children. Our findings suggest that parent-mediated play-based interventions hold promise for improving social functioning and related autistic characteristics for preschool autistic children.
The relationship between weight-adjusted-waist index and suicidal ideation: evidence from NHANES
Authors: Guo Shijie , Qing Guangwei , Chen Qiqi , Yang Guang 
Published: May 2024

Abstract
Background
Amidst growing evidence of the intricate link between physical and mental health, this study aims to dissect the relationship between the waist-to-weight index (WWI) and suicidal ideation within a representative sample of the US population, proposing WWI as a novel metric for suicide risk assessment.

Methods
The study engaged a sample of 9500 participants in a cross-sectional design. It employed multivariate logistic and linear regression analyses to probe the association between WWI and suicidal ideation. It further examined potential nonlinear dynamics using a weighted generalized additive model alongside stratified analyses to test the relationship's consistency across diverse demographic and health variables.

Results
Our analysis revealed a significant positive correlation between increased WWI and heightened suicidal ideation, characterized by a nonlinear relationship that persisted in the adjusted model. Subgroup analysis sustained the association's uniformity across varied population segments.

Conclusions
The study elucidates WWI's effectiveness as a predictive tool for suicidal ideation, underscoring its relevance in mental health evaluations. By highlighting the predictive value of WWI, our findings advocate for the integration of body composition considerations into mental health risk assessments, thereby broadening the scope of suicide prevention strategies.