bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adult fathead minnow, Pimephales promelas, partial life-cycle reproductive and gonadal histopathology study with bisphenol A
Authors: Mihaich Ellen , Rhodes Jon , Wolf Jeff , van der Hoeven Nelly , Dietrich Daniel , Hall A. Tilghman , Caspers Norbert , Ortego Lisa , Staples Charles , Dimond Steve , Hentges Steven 
Published: August 2012

Abstract
Bisphenol A (BPA) is an intermediate used to produce epoxy resins and polycarbonate plastics. Although BPA degrades rapidly in the environment with aquatic half-lives from 0.5 to 6 d, it can be found in aquatic systems because of widespread use. To evaluate potential effects from chronic exposure, fathead minnows were exposed for 164 d to nominal concentrations of 1, 16, 64, 160, and 640 µg/L BPA. Population-level endpoints of survival, growth, and reproduction were assessed with supplemental endpoints (e.g., vitellogenin, gonad histology), including gonad cell type assessment and quantification. No statistically significant changes in growth, gonad weight, gonadosomatic index, or reproduction variables (e.g., number of eggs and spawns, hatchability) were observed; however, there was a significant impact on male survival at 640 µg/L. Vitellogenin increased in both sexes at 64 µg/L or higher. Gonad cell type frequencies were significantly different from controls at 160 µg/L or higher in males with a slight decrease in spermatocytes compared with less mature cell types, and at 640 µg/L in females with a slight decrease in early vitellogenic cells compared with less mature cells. The decrease in spermatocytes did not correspond to a decrease in the most mature sex cell type (spermatozoa) and did not impair male fertility, as hatchability was not impacted. Overall, marginal shifts in gametogenic cell maturation were not associated with any statistically significant effects on population-relevant reproductive endpoints (growth, fecundity, and hatchability) at any concentration tested. Environ. Toxicol. Chem. 2012; 31: 2525–2535. © 2012 SETAC
Combined effect of cheese characteristics and food oral processing on in vivo aroma release
Authors: Repoux Marie , Labouré Hélène , Courcoux Philippe , Andriot Isabelle , Sémon Étienne , Yven Claude , Feron Gilles , Guichard Elisabeth 
Published: August 2012

ABSTRACTThe aim of this work was to clarify the influence of the properties (firmness and fat content) of a solid processed model cheese on in vivo aroma release while considering the role of the in‐mouth process during both mastication and post‐swallowing steps, and the hydrophobicity of aroma compounds, on a large number of well characterized subjects. In vivo aroma release was studied on 44 subjects who freely consumed six processed model cheeses flavoured with the same concentration of nonan‐2‐one and ethyl propanoate. Globally, an increase in firmness induced an increase in chewing duration, amount of saliva incorporated into the food bolus, total amount of aroma released and rate of release. The kinetics of release clearly differed between the two aroma compounds. Ethyl propanoate presented a higher release rate for firmer cheese and was more released during the mastication step, whereas nonan‐2‐one was more released during the post‐swallowing step and more persistent in the mouth, due to its higher hydrophobicity. Consuming cheeses with a higher fat content led to a higher amount of product remaining in the mouth after swallowing, a lower amount of nonan‐2‐one released and a longer persistence of nonan‐2‐one in the breath. The results could be helpful to better understand the relative influence of the parameters related to products and subjects in order to reformulate foods with good sensory acceptability. Copyright © 2012 John Wiley & Sons, Ltd.
Initial impacts of a wildfire on hydrology and suspended sediment and nutrient export in California chaparral watersheds
Authors: Coombs James Scott , Melack John M. 
Published: August 2012

AbstractStream and rainfall gauging and runoff sampling were used to determine changes in hydrology and export of nutrients and suspended sediment from a June 2004 wildfire that burned 3010 ha in chaparral coastal watersheds of the Santa Ynez Mountains, California. Precipitation during water year 2005 exceeded average precipitation by 200–260%. Burned watersheds had order of magnitude higher peak discharge compared with unburned watersheds but similar annual runoff. Suspended sediment export of 181 mt ha−1 from a burned watershed was approximately ten times greater than from unburned watersheds. Ammonium export from burned watersheds largely occurred during the first three storms and was 32 times greater than from unburned watersheds. Nitrate, dissolved organic nitrogen, and phosphate export from burned watersheds increased by 5.5, 2.8, and 2.2 times, respectively, compared with unburned chaparral watersheds. Storm runoff and peak discharge increase in burned compared with unburned sites were greatest during early season storms when enhanced runoff occurred. As the winter progressed, closely spaced storms and above average precipitation reduced the fire‐related impacts that resulted in significant increases in annual post‐fire runoff and export in other studies in southern California chaparral. Copyright © 2012 John Wiley & Sons, Ltd.
Automatic calibration of HEC‐HMS using single‐objective and multi‐objective PSO algorithms
Authors: Kamali Bahareh , Mousavi S. Jamshid , Abbaspour K.C. 
Published: August 2012

AbstractThis study presents single‐objective and multi‐objective particle swarm optimization (PSO) algorithms for automatic calibration of Hydrologic Engineering Center‐ Hydrologic Modeling Systems rainfall‐runoff model of Tamar Sub‐basin of Gorganroud River Basin in north of Iran. Three flood events were used for calibration and one for verification. Four performance criteria (objective functions) were considered in multi‐objective calibration where different combinations of objective functions were examined. For comparison purposes, a fuzzy set‐based approach was used to determine the best compromise solutions from the Pareto fronts obtained by multi‐objective PSO. The candidate parameter sets determined from different single‐objective and multi‐objective calibration scenarios were tested against the fourth event in the verification stage, where the initial abstraction parameters were recalibrated. A step‐by‐step screening procedure was used in this stage while evaluating and comparing the candidate parameter sets, which resulted in a few promising sets that performed well with respect to at least three of four performance criteria. The promising sets were all from the multi‐objective calibration scenarios which revealed the outperformance of the multi‐objective calibration on the single‐objective one. However, the results indicated that an increase of the number of objective functions did not necessarily lead to a better performance as the results of bi‐objective function calibration with a proper combination of objective functions performed as satisfactorily as those of triple‐objective function calibration. This is important because handling multi‐objective optimization with an increased number of objective functions is challenging especially from a computational point of view. Copyright © 2012 John Wiley & Sons, Ltd.
Mechanical properties of human bone surrounding plateau root form implants retrieved after 0.3–24 years of function
Authors: Baldassarri Marta , Bonfante Estevam , Suzuki Marcelo , Marin Charles , Granato Rodrigo , Tovar Nick , Coelho Paulo G. 
Published: August 2012

AbstractBone remodeling, along with tissue biomechanics, is critical for the clinical success of endosseous implants. This study evaluated the long‐term evolution of the elastic modulus (GPa) and hardness (GPa) of cortical bone around human retrieved plateau root form implants. Thirty implant‐in‐bone specimens showing no clinical failure were retrieved from patients at different in‐vivo times (0.3 to ∼24 years) due to retreatment needs. After dehydration, specimens were embedded in methacrylate‐based resin, sectioned along the bucco‐lingual long axis and fixed to acrylic plates and nondecalcified processed to slides with ∼50 μm in thickness. Nanoindentation testing was carried out under wet conditions on bone areas within the first three plateaus. Indentations (n = 120 per implant total) were performed with a maximum load of 300 μN (loading rate: 60 μN/s) followed by a holding and unloading time of 10 s and 2 s, respectively. Elastic modulus (E, GPa) and hardness (H, GPa) were computed. Both E and H values presented increased values as time in vivo elapsed (E: r = 0.84; H: r = 0.78). Significantly higher values for E and H were found after 5 years in vivo (p < 0.001). Maxillary or mandibulary arches or positioning did not affect mechanical properties, nor did implant surface treatment on the long‐term bone biomechanical response (E: p ≥ 0.09; H: p ≥ 0.3). This work suggests that human cortical bone around plateau root form implants presents an increase in elastic modulus and hardness during the first 5 years following implantation and presents stable mechanical properties thereafter. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.
The role of platelets in the treatment of Achilles tendon injuries
Authors: Sadoghi Patrick , Rosso Claudio , Valderrabano Victor , Leithner Andreas , Vavken Patrick 
Published: August 2012

AbstractTo systematically review the current in‐vivo evidence for the use of platelet‐concentrates (PRP) in the treatment of Achilles tendinopathy and Achilles tendon ruptures in animal models and human applications. A systematic search of PubMed, CINAHL, EMBASE, CCTR, and CDSR was performed for animal and human studies on the effect of platelet‐concentrates in the treatment of Achilles tendinopathy and ruptures using the terms “Achilles tendon and platelet.” The systematic search revealed a total of 149 papers. After excluding duplicates and cases of overlapping data, studies not focusing on in vivo evidence in terms of treatment or outcome, studies without any intervention, studies with unacceptable high attrition, one Chinese and one Swedish study, the remaining 14 manuscripts were included. The key finding of our study is evidence in support of a statistically significant effect of platelet concentrates in the treatment of Achilles tendon ruptures in vivo in animal models and human application, consistent with a medium to large sized effect. This effect is most likely attributable to fastened and enhanced scar tissue maturation. There was no evidence for a beneficial effect of platelets in Achilles tendinopathy. © 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31:111–118, 2012
A fluorescence lifetime imaging classification method to investigate the collagen to lipid ratio in fibrous caps of atherosclerotic plaque
Authors: Phipps Jennifer E. , Sun Yinghua , Fishbein Michael C. , Marcu Laura 
Published: August 2012

AbstractBackground and ObjectiveThis study describes a novel fluorescence lifetime imaging (FLIM) classification method to determine the ratio of collagen to lipid content in the fibrous cap of atherosclerotic plaques. Additionally, an analytical process to assess risk of plaque rupture based on this ratio is proposed. Collagen to lipid ratio has been shown to be an important parameter to evaluate structural integrity of the fibrous cap. FLIM and other time‐resolved fluorescence techniques have recently been applied to the study of atherosclerosis based on the ability to assess biochemical composition.Study Design/Materials and MethodsAutofluorescence of specimens retrieved during carotid endarterectomy procedures was measured through three optical filters, F377: 377/50 nm, F460: 460/66 nm, and F510: 510/84 nm (center wavelength/bandwidth). A Laguerre deconvolution technique was used for the evaluation of fluorescence decay dynamics. The resulting decay parameters (average fluorescence lifetime and 4 Laguerre coefficients at each of the recorded bandwidths) were used for sample characterization. Linear discriminant analysis (LDA) was used to classify each image into collagen or lipid‐rich regions based on these parameters. Ultimately, a risk‐level was assigned based on the ratio of collagen to lipid on the surface of the fibrous cap.ResultsFLIM images were acquired in 18 carotid plaque specimens at 43 locations. Classification of collagen and lipid‐rich regions within the fibrous cap was performed with sensitivity and specificity of 80% and 82%, respectively.ConclusionsResults from this study show that an LDA method of classifying regions of FLIM images of carotid plaque into collagen and lipid‐rich regions is capable of being automated and used to rate the risk of plaque rupture based on autofluorescence decay dynamics and without the need for fluorescence intensity or contrast agents. Lasers Surg. Med. 44: 564–571, 2012. © Wiley Periodicals, Inc.
Sagittal Clefting of the Fifth Lumbar Vertebra of a Young Adult Female from Apollonia Pontica, Bulgaria
Authors: Keenleyside Anne 
Published: August 2012

AbstractA rare congenital anomaly in the form of sagittal clefting of the fifth lumbar vertebra was observed in the skeleton of a young adult female excavated from the Greek colonial site of Apollonia Pontica (5th to 3rd centuries BC) on the Bulgarian Black Sea coast. No compensatory changes had occurred to the adjacent vertebrae, and no other skeletal anomalies or pathological conditions were observed in the skeleton. This anomaly, the first of its kind documented in ancient Greek remains, was likely asymptomatic and of no clinical significance. Copyright © 2012 John Wiley & Sons, Ltd.
Microstructural and microwave shielding characteristics of water‐soluble polypyrrole–polyvinyl alcohol–graphite oxide core–shell nanocomposites
Authors: Basavaraja C. , Thinh P.X. , Kim Won Jung , Revanasiddappa M. , Huh Do Sung 
Published: August 2012

AbstractThis article reports on a facile route for the preparation of polypyrrole–polyvinyl alcohol–graphite oxide nanocomposites through the polymerization of pyrrole with different concentration (wt%) of graphite oxide using ammonium persulfate as an oxidant. The synthesized nanocomposites were characterized by Fourier transform infrared spectroscopy, and their surface morphologies were studied by scanning electron microscopy and transmission electron microscopy. Their solubility in water, DC conductivity in solution, and the current–voltage characteristics of the nanocomposites were studied. Furthermore, the microwave absorption at 1.0–10.0 MHz and the effects of sample thickness on the microwave absorption were investigated. The composites including higher concentration of graphite oxide showed increased solubility and electrical conductivity, and high electromagnetic shielding effectiveness. POLYM. COMPOS. 2012. © 2012 Society of Plastics Engineers
Pseudo‐Hermitian random matrix theory
Authors: Srivastava S.C.L. , Jain S.R. 
Published: August 2012

AbstractComplex extension of quantum mechanics and the discovery of pseudo‐unitarily invariant random matrix theory has set the stage for a number of applications of these concepts in physics. We briefly review the basic ideas and present applications to problems in statistical mechanics where new results have become possible. We have found it important to mention the precise directions where advances could be made if further results become available.
Genetic differentiation in populations of the yellow‐necked mouse, Apodemus flavicollis, harbouring B chromosomes in different frequencies
Authors: Adnađević Tanja , Bugarski‐Stanojević Vanja , Blagojević Jelena , Stamenković Gorana , Vujošević Mladen 
Published: August 2012

AbstractTwo alternative models are used to explain maintenance of polymorphism of B chromosomes (Bs) in populations of a great number of species. The parasitic model suggests deleterious effects of Bs on fitness of carriers, while the heterotic model assumes that, in the absence of drive, equilibrium is produced by beneficial effects of Bs at low numbers. In order to determine the potential contribution of Bs to genetic differentiation and diversity, four populations of Apodemus flavicollis, differing in frequency of Bs (from 0.23 to 0.38) and settled in ecologically different habitats, were analyzed by 471 AFLP markers. Although numerous loci were demonstrated to be population specific, none of them was associated with individuals with Bs. AMOVA showed that the presence of Bs does not affect population differentiation, pointing to greater genetic similarity of Bs to A chromosomes. The greatest genetic diversity (0.241) was found in the population settled in optimal conditions for this species featured by the lowest frequency of animals with Bs (0.23). We found that the majority of loci marked as loci under directional selection, are characteristic of either a population with lower or one with a higher frequency of Bs. Several loci detected as outliers were associated with environmental variables that could directly and/or indirectly influence population dynamics of A. flavicollis. Thus, we suggest that the different frequency of Bs carriers in populations is related to adaptive differentiation to diverse habitats, which is in accordance with the heterotic model of Bs maintenance.
Retrospective Review of Efficacy of Radiofrequency Ablation for Treatment of Colorectal Cancer Liver Metastases from a Canadian Perspective
Authors: Kwan Benjamin Y.M. , Kielar Ania Z. , El-Maraghi Robert H. , Garcia Lourdes M. 
Published: August 2012

Purpose A retrospective single-center review of ultrasound-guided radiofrequency ablation (RFA) treatment of colorectal cancer liver metastases was performed. This study reviews the primary and secondary technical effectiveness, overall survival of patients, recurrence-free survival, tumour-free survival, rates of local recurrence, and postprocedural RFA complications. Technical effectiveness and rates of complication with respect to tumour location and size were evaluated. Our results were compared with similar studies from Europe and North America. Methods A total of 63 patients (109 tumours) treated with RFA between February 2004 and December 2009 were reviewed. Average and median follow-up time was 19.4 and 16.5 months, respectively (range, 1–54 months). Data from patient charts, pathology, and Picture Archiving and Communication System was integrated into an Excel database. Statistical Analysis Software was used for statistical analysis. Results Primary and secondary technical effectiveness of percutaneous and intraoperative RFA were 90.8% and 92.7%, respectively. Average (SE) tumour-free survival was 14.4 ± 1.4 months (range, 1–43 months), and average (SE) recurrence-free survival was 33.5 ± 2.3 months (range, 2–50 months). Local recurrence was seen in 31.2% of treated tumours (range, 2–50 months) (34/109). Overall survival was 89.4% at 1 year, 70.0% at 2 years, and 38.1% at 3 years, with an average (SE) overall survival of 37.0 ± 2.8 months. There were 14 postprocedural complications. There was no statistically significant difference in technical effectiveness for small tumours (1–2 cm) vs intermediate ones (3–5 cm). There was no difference in technical effectiveness for peripheral vs parenchymal tumours. Conclusions This study demonstrated good-quality outcomes for RFA treatment of colorectal cancer liver metastases from a Canadian perspective and compared favorably with published studies.
Catheter Fracture and Embolization Associated with Arm Implantation of the Cook Vital Port
Authors: Burbridge Brent , Stoneham Grant , Szkup Peter , Otani Rob , Kriegler Stefan 
Published: August 2012

Purpose To determine the frequency of arm port catheter fracture and embolization related to the Cook Vital Port Mini Titanium. Materials and Methods A retrospective audit of our Cerner Radiology Information System was performed between June 1, 2006, and June 30, 2011, to determine the number of Cook arm venous ports implanted and the frequency of foreign body retrievals related to catheter fracture for these arm ports. Results A total of 691 arm implantations of the Cook Vital Port during the 5-year time frame were analysed. Eleven of these patients (1.6%) required intravenous foreign body retrieval in the interventional radiology suite related to catheter fracture and embolization. Three of these fractured catheters were retrieved from the peripheral venous system upstream of the pulmonary circulation, whereas 8 embolized to the pulmonary arteries. All were successfully extracted with an intravenous snare by interventional radiology. Conclusion We discovered a 1.6% frequency of catheter fracture and embolization associated with arm implantation of the Cook Vital Port. All the catheters fractured at the vein entry site and did not detach from the port housing. The cause for catheter fracture and embolization is uncertain. Pulmonary embolization of the fractured catheters puts the patients at risk for possible further complications. No patients had ancillary complications related to catheter embolization or to catheter extraction procedures. Further investigation is required in an attempt to determine the circumstances that may result in catheter fracture and embolization related to this venous access device.
Ultrasound-Guided Fine-Needle Aspiration Biopsy of the Thyroid: Methods to Decrease the Rate of Unsatisfactory Biopsies in the Absence of an On-Site Pathologist
Authors: Naïm Cyrille , Karam Ramy , Eddé Donald 
Published: August 2012

Purpose The rate of unsatisfactory samples from ultrasound-guided fine-needle aspirations of thyroid nodules varies widely in the literature. We aimed to evaluate our thyroid ultrasound-guided fine-needle aspiration biopsy technique in the absence of on-site microscopic examination by a pathologist; determine factors that affect the adequacy rate, such as the number of needle passes and needle size; compare our results with the literature; and establish an optimal technique. Materials and Methods We performed a retrospective review of cytopathology reports from 252 consecutive thyroid ultrasound-guided fine-needle aspiration biopsies performed by a radiologist between 2005 and 2010 in our hospital's radiology department. Sample adequacy, the number of needle passes, and needle size were determined. There was an on-site cytologist who prepared slides immediately after fine-needle aspiration but no on-site microscopic assessment of sample adequacy to guide the number of needle passes that should be performed. Cytopathology biopsy reports were classified as either unsatisfactory or satisfactory samples for diagnosis; the latter consisted of benign, malignant, and undetermined diagnoses. Results Seventy-seven biopsies were performed with 1 needle pass, 124 with 2 needle passes, and 51 with 3 needle passes. The rates of unsatisfactory biopsies were 33.8%, 23.4% (odds ratio [OR] 0.599 [95% confidence interval {CI}, 0.319-1.123]; P = .110), and 13.7% (OR 0.312 [95% CI, 0.124-0.788]; P = .014), respectively. Conclusion In a hospital in which there is no on-site pathologist, a 3-pass method increases the specimen satisfactory rate by 20% compared with 1 pass, achieves similar rates to the literature, and provides a basis for further improvement of our practice.