bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic benefit of transcatheter aortic valve implantation compared with medical therapy in patients with inoperable aortic stenosis
Authors: Rajani Ronak , Buxton William , Haworth Peter , Khawaja Muhammed Z. , Sohal Manav , Brum Roberta L. , Hutchinson Nevil , de Belder Adam , Trivedi Uday , Hildick‐Smith David 
Published: December 2009

AbstractObjectives: To compare survival in patients with inoperable aortic stenosis who undergo transcatheter aortic valve implantation against those managed medically. Background: Without surgical correction, survival of patients with severe symptomatic aortic stenosis is poor. It is unknown whether patients undergoing transcatheter aortic valve implantation (TAVI) have a better prognosis than similar patients who are treated with medical management. Methods: Survival rates were compared in consecutive patients with severe symptomatic aortic stenosis who either underwent TAVI or continued on medical management following multidisciplinary team assessment. All patients had been turned down, or considered at unacceptably high risk, for conventional aortic valve surgery. Patients were reviewed in clinic or by telephone six monthly. Mortality data was obtained from the United Kingdom Office of National Statistics. Results: The study group included 85 patients aged 81 ± 7 years (range 62–94), of whom 48 were male. Thirty eight patients underwent TAVI while 47 patients were deemed unsuitable based on echocardiographic, angiographic, or clinical criteria and remained on medical therapy. The calculated EuroSCORE for the TAVI group was 11 ± 2 and for the medical group 9 ± 2 (P < 0.001). TAVI‐related procedural mortality was 2.6%, and 30‐day mortality was 5.2%. Among the medically‐treated patients, 14 (30%) underwent palliative balloon aortic valvuloplasty, with a trend toward improved survival (P = 0.06). During overall follow‐up of 215 ± 115 days there were a total of 18 deaths; TAVI N = 5 (13%); Medical N = 13 (28%) (P = 0.04). Conclusions: Patients with severe aortic valve disease who are not suitable for surgical aortic valve replacement have an improved prognosis if treated with transcatheter aortic valve implantation rather than continuing on medical management alone. © 2010 Wiley‐Liss, Inc.
The Role of Solvent on the Mechanism of Proton Transfer to Hydride Complexes: The Case of the [W3PdS4H3(dmpe)3(CO)]+ Cubane Cluster
Authors: Algarra Andrés G. , Basallote Manuel G. , Feliz Marta , Fernández‐Trujillo M. Jesús , Llusar Rosa , Safont Vicent S. 
Published: December 2009

AbstractThe kinetics of reaction of the [W3PdS4H3(dmpe)3(CO)]+ hydride cluster (1+) with HCl has been measured in dichloromethane, and a second‐order dependence with respect to the acid is found for the initial step. In the presence of added BF4− the second‐order dependence is maintained, but there is a deceleration that becomes more evident as the acid concentration increases. DFT calculations indicate that these results can be rationalized on the basis of the mechanism previously proposed for the same reaction of the closely related [W3S4H3(dmpe)3]+ cluster, which involves parallel first‐ and second‐order pathways in which the coordinated hydride interacts with one and two acid molecules, and ion pairing to BF4− hinders formation of dihydrogen bonded adducts able to evolve to the products of proton transfer. Additional DFT calculations are reported to understand the behavior of the cluster in neat acetonitrile and acetonitrile–water mixtures. The interaction of the HCl molecule with CH3CN is stronger than the WH⋅⋅⋅HCl dihydrogen bond and so the reaction pathways operating in dichloromethane become inefficient, in agreement with the lack of reaction between 1+ and HCl in neat acetonitrile. However, the attacking species in acetonitrile–water mixtures is the solvated proton, and DFT calculations indicate that the reaction can then go through pathways involving solvent attack to the W centers, while still maintaining the coordinated hydride, which is made possible by the capability of the cluster to undergo structural changes in its core.
Sturzabdichtungen in Verblendfassaden
Authors: Oswald Rainer 
Published: December 2009

AbstractZweischalige, kerngedämmte Verblendfassaden schützen zuverlässig vor Schlagregen. Feuchteschäden sind fast ausschließlich unter den Stürzen der Bauwerksöffnungen zu beobachten. Warum Fußpunktabdichtungen gerade in diesem Bereich versagen und welche Regeln zu beachten sind, wird im Folgenden dargestellt.
Praxistipps und Hinweise aus der Rechtsprechung für die Bewertung von Mauerwerkskonstruktionen
Authors: Rast Ronald 
Published: December 2009

AbstractDas Thema “Ausführung von Mauerwerk” steht in regelmäßigen Abständen immer wieder im Blickpunkt der Fachöffentlichkeit. Zur Zeit diskutieren im Umfeld der Einspruchssitzung zur überarbeiteten DIN 1053 – Teil 12 erneut Wissenschaftler, Sachverständige sowie Vertreter der Mauerwerksindustrie und der Bauausführung aktuelle und praxisrelevante Fragen zur Ausführung von Mauerwerksarbeiten.Neben der Vorbereitung der Verabschiedung des überarbeiteten Normenteils zur DIN 1053 – Teil 12 zur “Ausführung von Mauerwerk” geht es in diesem Beitrag darum, Hinweise und Tipps für die Bewertung von Mauerwerkskonstruktionen in der Baupraxis und Rechtsprechung zu erarbeiten. Planern, Bauausführenden und Bauherren soll damit eine größere Sicherheit im praktischen Umgang mit den gültigen Normen vermittelt werden.
Pyrazine‐Assisted Dimerization of Molybdenum(V): Synthesis and Structural Characterization of Novel Dinuclear and Tetranuclear Complexes
Authors: Modec Barbara , Šala Martin , Clérac Rodolphe 
Published: December 2009

AbstractReactions of pyrazine (Pyz = C4H4N2) with [MoOCl4(H2O)]– or [MoOBr4]– afforded a series of complexes, dinuclear [(MoOX4)2(Pyz)]2– (X = Cl, Br), [{MoOCl3(Pyz)}2O]2– and tetranuclear [(Mo2O4Cl4)2(Pyz)2]4– anions, with N‐donor ligands engaged either in monodentate or bidentate bridging coordination. A dinuclear [(MoOX4)2(Pyz)]2– ion, which may be viewed as a linkage of two mononuclear subunits with a bidentate pyrazine, crystallizes either as a PyH+ (pyridinium cation, C5H5NH+; compound 1), a {(C2H5)4N}+ (compound 2) or a {(C6H5)4P}+ salt (compounds 3 and 4). In (PyH)2[{MoOCl3(Pyz)}2O] (5) with an anti‐{Mo2O3}4+ core, pyrazine is bound to the metal through only one nitrogen atom. The tetranuclear [(Mo2O4Cl4)2(Pyz)2]4– ion, a linkage of two metal–metal bonded {Mo2O4}2+ cores with a pair of bidentate pyrazines, is found in two compounds, (MeNC5H5)2(PyzH2)[(Mo2O4Cl4)2(Pyz)2] (6) [MeNC5H5+ = N‐methylpyridinium cation, PyzH22+ = pyrazinium(2+) cation] and (PyH)4[(Mo2O4Cl4)2(Pyz)2]·2CH3CN (7). In the presence of methanol, dinuclear {(C6H5)4P}2[(MoOBr4)2(Pyz)]·2CH3CN (4) was transformed directly into tetranuclear (PyH)4[(Mo2O4Br4)2(Pyz)2]·2CH3CN (8). All compounds were fully characterized by X‐ray crystallography and IR spectroscopy. The compounds containing the [(MoOX4)2(Pyz)]2– ions display an irreversible electrochemical reduction behaviour. Temperature‐dependent magnetic measurements on {(C6H5)4P}2[(MoOX4)2(Pyz)]·2CH3CN (X = Cl for 3, X = Br for 4) reveal a weak ferromagnetic coupling across the pyrazine bridge between a pair of MoV S = 1/2 spins. The magnetic properties of {(C2H5)4N}2[(MoOCl4)2(Pyz)] (2), another compound with dinuclear complex anions, are dominated by antiferromagnetic intermolecular interactions.
Ring‐Rearrangement Metathesis (RRM) Mediated by Ruthenium‐Indenylidene Complexes
Authors: Clavier Hervé , Broggi Julie , Nolan Steven P. 
Published: December 2009

AbstractSeveral ruthenium‐indenylidene complexes bearing N‐heterocyclic carbenes (NHCs) and phosphanes have been investigated for the ring rearrangement of cyclic compounds by alkene metathesis. These catalysts were found to promote efficiently such domino reactions, especially sterically hindered NHC‐containing complexes. Moreover, indenylidene‐type catalysts were compared to benzylidene‐ and Hoveyda‐type analogues. The scope of the reaction highlights the parameters governing the RRM.
Role of radiotherapy in early glottic carcinoma
Authors: Smee Robert I. , Meagher Nicola S. , Williams Janet R. , Broadley Kathryn , Bridger G. Patrick 
Published: December 2009

AbstractBackgroundEarly glottic carcinoma has a high local control prospect with radiotherapy. This review evaluates a single center's experience.MethodsAll patients from 1967 to 2006 diagnosed with Tis/T1/T2/N0 early glottic carcinoma treated definitively with radiotherapy at Prince of Wales Hospital were reviewed. Local control and cancer‐specific survival (CSS) rates were primary endpoints, and the impact of various factors on these outcomes was statistically analyzed.ResultsThis review of 522 patients includes 24 with Tis, 356 with T1, and 142 with T2. Ultimate local control rates were as follows: Tis 87.5%, T1 94.7%, and T2 84.5%. Multivariate analysis found fitness for surgery, no involvement of anterior commissure, normal cord movement, and radiotherapy dose >60 Gy significant for local control. Fitness for surgery, no involvement of the anterior commissure, normal cord movement, and no ventricular involvement were significant prognostic factors for CSS.ConclusionDefinitive radiotherapy for early glottic carcinoma provides high local control rates, with the option of surgical salvage to achieve ultimate local control. © 2009 Wiley Periodicals, Inc. Head Neck, 2010
Olanzapine monotherapy for acute depression in patients with bipolar I or II disorder: results of an 8‐week open label trial
Authors: Bobo William V. , Epstein Richard A. , Shelton Richard C. 
Published: December 2009

AbstractWe evaluated the efficacy, tolerability, and safety of olanzapine monotherapy in 20 adult patients with bipolar I or II disorder, depressed phase. Patients received open‐label olanzapine monotherapy (mean modal dose, 15 mg/day) for 8 weeks. Assessments of psychopathology (Montgomery–Asberg Depression Rating Scale [MADRS], Quick Inventory of Depressive Symptomatology [QIDS‐SR‐16], Young Mania Rating Scale [YMRS]), clinical global state (Clinical Global Impressions [CGI] scale), and safety/tolerability were performed at baseline, and at 1, 2, 4, 6, and 8 weeks. Seventeen patients (85.0%) completed the study. Improvement in MADRS total scores was observed after the first week of treatment, and at all remaining follow‐up time points (p ≤ 0.005). Parallel improvement in QIDS‐SR‐16 (p < 0.001) and CGI‐Severity (p < 0.001) was observed between baseline and study endpoint. Nine (45%) subjects achieved positive treatment response, eight of whom (40%) also achieved symptom remission. There were significant increases in weight (+3.2 kg, p = 0.001) and body mass index (+1.1 kg/m2, p = 0.001), but not fasting glucose or lipids, with the exception of reduced triglyceride levels in the overall sample, and reduced HDL cholesterol in females. Olanzapine may be an effective, well‐tolerated option for treating acute non‐psychotic depression across a variety of bipolar disorder subtypes. Copyright © 2009 John Wiley & Sons, Ltd.
Selective probing of a NADPH site controlled light‐induced enzymatic catalysis
Authors: Lambry Jean‐Christophe , Beaumont Edward , Tarus Bogdan , Blanchard‐Desce Mireille , Slama‐Schwok Anny 
Published: December 2009

AbstractAchieving molecular recognition of NADPH binding sites is a compelling strategy to control many redox biological processes. The NADPH sites recognize the ubiquitous NADPH cofactor via highly conserved binding interactions, despite differences in the regulation of the hydride transfer in redox active proteins. We recently developed a photoactive NADPH substitute, called nanotrigger NT synchronizing the initiation of enzymatic catalysis of the endothelial NO‐synthase (eNOS) with a laser pulse. Spatial and temporal control of enzymatic activity by such a designed light‐driven activator would benefit from achieving molecular selectivity, i.e. activation of a single NADPH‐mediated enzyme.In this work, we probe the ability of NT to discriminate between two NADPH sites with light. The selected NADPH sites belong to dihydrofolate reductase dihydrofolate reductase enzyme (DHFR) and endothelial NO‐synthase (eNOS). Ultrafast kinetics showed that NT could not activate DHFR catalysis with a laser pulse in contrast with the observed trigger of eNOS catalysis leading to NO formation. Homology modelling, molecular dynamics simulations showed that NT discriminated between the two NADPH sites by different donor to acceptor distances and by local steric effects hindering light activation of DHFR catalysis. The data suggested that the narrow NADPH site required a tight fit of the nanotrigger at a suitable distance/angle to the electron acceptor for a specific activation of the catalysis. The ability of the nanotrigger to activate eNOS combined with a low reactivity in unfavourable NADPH sites makes NT a highly promising tool for targeting eNOS in endothelial cells with a laser pulse. Copyright © 2009 John Wiley & Sons, Ltd.
Hepatitis C infection among intravenous drug users attending therapy programs in Cyprus
Authors: Demetriou Victoria L. , van de Vijver David A.M.C. , Hezka Johana ,   the Cyprus IVDU Network, Kostrikis Leondios G. 
Published: December 2009

AbstractThe most high‐risk population for HCV transmission worldwide today are intravenous drug users. HCV genotypes in the general population in Cyprus demonstrate a polyphyletic infection and include subtypes associated with intravenous drug users. The prevalence of HCV, HBV, and HIV infection, HCV genotypes and risk factors among intravenous drug users in Cyprus were investigated here for the first time. Blood samples and interviews were obtained from 40 consenting users in treatment centers, and were tested for HCV, HBV, and HIV antibodies. On the HCV‐positive samples, viral RNA extraction, RT‐PCR and sequencing were performed. Phylogenetic analysis determined subtype and any relationships with database sequences and statistical analysis determined any correlation of risk factors with HCV infection. The prevalence of HCV infection was 50%, but no HBV or HIV infections were found. Of the PCR‐positive samples, eight (57%) were genotype 3a, and six (43%) were 1b. No other subtypes, recombinant strains or mixed infections were observed. The phylogenetic analysis of the injecting drug users' strains against database sequences observed no clustering, which does not allow determination of transmission route, possibly due to a limitation of sequences in the database. However, three clusters were discovered among the drug users' sequences, revealing small groups who possibly share injecting equipment. Statistical analysis showed the risk factor associated with HCV infection is drug use duration. Overall, the polyphyletic nature of HCV infection in Cyprus is confirmed, but the transmission route remains unknown. These findings highlight the need for harm‐reduction strategies to reduce HCV transmission. J. Med. Virol. 82:263–270, 2010. © 2009 Wiley‐Liss, Inc.
Behavioral and electrophysiological effects of 5‐HT in globus pallidus of 6‐hydroxydopamine lesioned rats
Authors: Zhang Shu‐Jing , Wang Hua , Xue Yan , Yung Wing‐Ho , Chen Lei 
Published: December 2009

AbstractAnatomical studies have shown that the globus pallidus receives abundant 5‐hydroxytryptamine (5‐HT) innervations from raphe nuclei. 5‐HT may occupy an important position in the modulation of motor function through its affect on the activity of globus pallidus. In the present study, intrapallidal microinjection of 5‐HT (0.1 mM) alone did not induce any motor behavior or postural asymmetry in the unilateral 6‐hydroxydopamine (6‐OHDA)‐lesioned rats. However, when infused concomitantly with a low dose of 3, 4‐dihydroxyphenylalanine (L‐DOPA, 3 mg/kg i.p.), which itself can induce modest contralateral rotational behavior, 5‐HT significantly potentiated the number of contralateral rotations. To elucidate the cellular mechanism, in vivo extracellular recordings were performed to examine the effects of 5‐HT on globus pallidus neurons. In normal rats, the predominant effect of micropressure ejection of 5‐HT on pallidal neurons was excitation. In 6‐OHDA‐lesioned rats, although 5‐HT increased the firing rate in most pallidal neurons, 5‐HT‐induced inhibitory effects was stronger than that on the unlesioned side as well as normal rats. Furthermore, 5‐HT1Breceptors are mainly involved in 5‐HT‐induced excitation while 5‐HT1Areceptors are involved in 5‐HT‐induced inhibition. The results suggest that 5‐HT may potentiate the antiparkinsonian effect of L‐DOPA through modulating the activity of globus pallidus. © 2009 Wiley‐Liss, Inc.
Coumarins and phenolic fingerprints of oak and Brazilian woods extracted by sugarcane spirit
Authors: da Silva Alexandre Ataide , do Nascimento Eduardo Sanches Pereira , Cardoso Daniel Rodrigues , Franco Douglas Wagner 
Published: December 2009

AbstractA total of 25 sugarcane spirit extracts of six different Brazilian woods and oak, commonly used by cooperage industries for aging cachaça, were analyzed for the presence of 14 phenolic compounds (ellagic acid, gallic acid, vanillin, syringaldehyde, synapaldehyde, coniferaldehyde, vanillic acid, syringic acid, quercetin, trans‐resveratrol, catechin, epicatechin, eugenol, and myricetin) and two coumarins (scopoletin and coumarin) by HPLC‐DAD‐fluorescence and HPLC‐ESI‐MSn. Furthermore, an HPLC‐DAD chromatographic fingerprint was build‐up using chemometric analysis based on the chromatographic elution profiles of the extracts monitored at 280 nm. Major components identified and quantified in Brazilian wood extracts were coumarin, ellagic acid, and catechin, whereas oak extracts shown a major contribution of catechin, vanillic acid, and syringaldehyde. The main difference observed among oak and Brazilian woods remains in the concentration of coumarin, catechin, syringaldehyde, and coniferaldehyde. The chemometric analysis of the quantitative profile of the 14 phenolic compounds and two coumarins in the wood extracts provides a differentiation between the Brazilian wood and oak extracts. The chromatographic fingerprint treated by multivariate analysis revealed significant differences among Brazilian woods themselves and oak, clearly defining six groups of wood extracts: (i) oak extracts, (ii) jatobá extracts, (iii) cabreúva‐parda extracts, (iv) amendoim extracts, (v) canela‐sassafrás extracts and (vi) pequi extracts.
Lagrangean‐based decomposition algorithms for multicommodity network design problems with penalized constraints
Authors: Bektaş Tolga , Chouman Mervat , Crainic Teodor Gabriel 
Published: December 2009

AbstractThis article discusses problems in the context of multicommodity network design where additional constraints (such as capacity), rather than being imposed in a strict manner, are allowed to be violated at the expense of additional penalty costs. Such penalized cost structures allow these constraints to be treated as utilization targets and provide a better modelling framework in terms of strategic or tactical level planning of network design, especially in freight transportation systems. However, due to the penalized costs, these problems are generally in the form of a nonlinear integer multicommodity network design problem. This article presents two algorithms based on Lagrangean relaxation and decomposition for the solution of such problems. The first relies upon dualizing the capacity constraints that results in a flow decomposition, and the second is through relaxing flow constraints that results in an arc decomposition. It is shown that nonlinearities in the decomposed substructures can be handled in a very efficient manner. Arc decomposition is shown, through computational experiments, to have better convergence properties. Through the proposed algorithms, reasonably good solutions can be obtained for these problems where publicly available state‐of‐the‐art nonlinear optimization codes fail to identify feasible solutions. © 2009 Wiley Periodicals, Inc. NETWORKS, 2010
Mobilizing against hunger and poverty: Capacity and change in a Brazilian social mobilization network
Authors: Schnell Sabina , Saxby John 
Published: December 2009

AbstractThis article examines the 16‐year history of a Brazilian social mobilization network through the lenses of organizational change, capacity development, and network management. Created by an inspirational leader and his group of friends at a favorable political juncture, COEP has survived and thrived because it managed to mobilize a wide array of public, private, and third‐sector organizations under the common banner of social justice and solidarity. It has succeeded by adopting a non‐hierarchical, yet structured, organizational configuration that leaves room for members' initiative, while at the same time maintains internal consistency and integrity. COEP illustrates well the importance of the intangible elements of capacity, such as legitimized and inspirational leadership and the ability for strategic thinking, for anticipating and reacting to change while maintaining the core mission and values of the network. COEP's capacity is the result of the fortuitous confluence of institutional and personal, material and intangible qualities of the people and organizations that constitute it. Copyright © 2010 John Wiley & Sons, Ltd.
Variable presence of KITD816V in clonal haematological non‐mast cell lineage diseases associated with systemic mastocytosis (SM–AHNMD)
Authors: Sotlar Karl , Colak Sema , Bache Anja , Berezowska Sabina , Krokowski Manuela , Bültmann Burkhard , Valent Peter , Horny Hans‐Peter 
Published: December 2009

AbstractIn a substantial number of patients with systemic mastocytosis (SM), an associated clonal haematological non‐mast cell lineage disease (AHNMD) is detectable. Although most of these patients display KIT mutations, especially KITD816V, little is known about their exact frequency and their distribution in AHNMD subtypes. We examined 48 patients with SM–AHNMD for the presence of mutant KIT in the SM and AHNMD components of the disease. Mast cells and AHNMD cells were obtained from immunostained bone marrow sections by laser microdissection and examined by melting point analysis of nested‐PCR products. KITD816V was found in AHNMD cells in the vast majority of patients with SM–chronic myelomonocytic leukaemia (CMML, 89%). Unexpectedly, KITD816V was far less frequently detectable in AHNMD cells in patients with SM–myeloproliferative neoplasm (MPN, 20%) and SM–acute myeloid leukaemia (AML, 30%). None of the patients with lymphoproliferative AHNMDs displayed KIT codon 816 mutations in AHNMD cells (0/8). In FIP1L1/PDGFRA‐positive chronic eosinophilic leukaemia (CEL), neither the SM nor the CEL component of the disease exhibited the KIT mutation. Our findings demonstrate that KIT codon 816 mutations are variably present in AHNMD cells in patients with SM–AHNMD, depending on the subtype of AHNMD. The high frequency of KITD816V in neoplastic mast cells and leukaemic myelomonocytic cells in SM–CMML may point to a common precursor in these patients, and may have implications for the biology of the disease and the development of KIT‐targeting therapies. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.