bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Childhood Adversity, Toxic Stress, and the Role of the Pediatrician: Translating Developmental Science Into Lifelong Health
Authors:   Committee on Psychosocial Aspects of Child and Family Health, Committee on Early Childhood, Adoption, and Dependent Care, and Section on Developmental and Behavioral Pediatrics, Garner Andrew S. , Shonkoff Jack P. , Siegel Benjamin S. , Dobbins Mary I. , Earls Marian F. , Garner Andrew S. , McGuinn Laura , Pascoe John , Wood David L. 
Published: December 2011

This Policy Statement was revised. See https://doi.org/10.1542/peds.2021-052582.
Advances in a wide range of biological, behavioral, and social sciences are expanding our understanding of how early environmental influences (the ecology) and genetic predispositions (the biologic program) affect learning capacities, adaptive behaviors, lifelong physical and mental health, and adult productivity. A supporting technical report from the American Academy of Pediatrics (AAP) presents an integrated ecobiodevelopmental framework to assist in translating these dramatic advances in developmental science into improved health across the life span. Pediatricians are now armed with new information about the adverse effects of toxic stress on brain development, as well as a deeper understanding of the early life origins of many adult diseases. As trusted authorities in child health and development, pediatric providers must now complement the early identification of developmental concerns with a greater focus on those interventions and community investments that reduce external threats to healthy brain growth. To this end, AAP endorses a developing leadership role for the entire pediatric community—one that mobilizes the scientific expertise of both basic and clinical researchers, the family-centered care of the pediatric medical home, and the public influence of AAP and its state chapters—to catalyze fundamental change in early childhood policy and services. AAP is committed to leveraging science to inform the development of innovative strategies to reduce the precipitants of toxic stress in young children and to mitigate their negative effects on the course of development and health across the life span.
The Lifelong Effects of Early Childhood Adversity and Toxic Stress
Authors: Shonkoff Jack P. , Garner Andrew S. ,   THE COMMITTEE ON PSYCHOSOCIAL ASPECTS OF CHILD AND FAMILY HEALTH, COMMITTEE ON EARLY CHILDHOOD, ADOPTION, AND DEPENDENT CARE, AND SECTION ON DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS, Siegel Benjamin S. , Dobbins Mary I. , Earls Marian F. , Garner Andrew S. , McGuinn Laura , Pascoe John , Wood David L. 
Published: December 2011

This Technical Report was retired November 2021.Advances in fields of inquiry as diverse as neuroscience, molecular biology, genomics, developmental psychology, epidemiology, sociology, and economics are catalyzing an important paradigm shift in our understanding of health and disease across the lifespan. This converging, multidisciplinary science of human development has profound implications for our ability to enhance the life prospects of children and to strengthen the social and economic fabric of society. Drawing on these multiple streams of investigation, this report presents an ecobiodevelopmental framework that illustrates how early experiences and environmental influences can leave a lasting signature on the genetic predispositions that affect emerging brain architecture and long-term health. The report also examines extensive evidence of the disruptive impacts of toxic stress, offering intriguing insights into causal mechanisms that link early adversity to later impairments in learning, behavior, and both physical and mental well-being. The implications of this framework for the practice of medicine, in general, and pediatrics, specifically, are potentially transformational. They suggest that many adult diseases should be viewed as developmental disorders that begin early in life and that persistent health disparities associated with poverty, discrimination, or maltreatment could be reduced by the alleviation of toxic stress in childhood. An ecobiodevelopmental framework also underscores the need for new thinking about the focus and boundaries of pediatric practice. It calls for pediatricians to serve as both front-line guardians of healthy child development and strategically positioned, community leaders to inform new science-based strategies that build strong foundations for educational achievement, economic productivity, responsible citizenship, and lifelong health.
The Importance of Play in Promoting Healthy Child Development and Maintaining Strong Parent-Child Bond: Focus on Children in Poverty
Authors: Milteer Regina M. , Ginsburg Kenneth R. ,   COUNCIL ON COMMUNICATIONS AND MEDIA COMMITTEE ON PSYCHOSOCIAL ASPECTS OF CHILD AND FAMILY HEALTH, Mulligan Deborah Ann , Ameenuddin Nusheen , Brown Ari , Christakis Dimitri A. , Cross Corinn , Falik Holly Lee , Hill David L. , Hogan Marjorie J. , Levine Alanna Estin , O’Keeffe Gwenn S. , Swanson Wendy Sue 
Published: December 2011

This Clinical Report was revised. See https://doi.org/10.1542/peds.2018-2058.
Play is essential to the social, emotional, cognitive, and physical well-being of children beginning in early childhood. It is a natural tool for children to develop resiliency as they learn to cooperate, overcome challenges, and negotiate with others. Play also allows children to be creative. It provides time for parents to be fully engaged with their children, to bond with their children, and to see the world from the perspective of their child. However, children who live in poverty often face socioeconomic obstacles that impede their rights to have playtime, thus affecting their healthy social-emotional development. For children who are underresourced to reach their highest potential, it is essential that parents, educators, and pediatricians recognize the importance of lifelong benefits that children gain from play.
Endorsement of Health and Human Services Recommendation for Pulse Oximetry Screening for Critical Congenital Heart Disease
Authors:   SECTION ON CARDIOLOGY AND CARDIAC SURGERY EXECUTIVE COMMITTEE, Mahle William T. , Martin Gerard R. , Beekman Robert H. , Morrow W. Robert , Rosenthal Geoffrey L. , Snyder Christopher S. , Minich L. LuAnn , Mital Seema , Towbin Jeffrey A. , Tweddell James S. 
Published: December 2011

Incorporation of pulse oximetry to the assessment of the newborn infant can enhance detection of critical congenital heart disease (CCHD). Recently, the Secretary of Health and Human Services (HHS) recommended that screening for CCHD be added to the uniform screening panel. The American Academy of Pediatrics (AAP) has been a strong advocate of early detection of CCHD and fully supports the decision of the Secretary of HHS.
The AAP has published strategies for the implementation of pulse oximetry screening, which addressed critical issues such as necessary equipment, personnel, and training, and also provided specific recommendations for assessment of saturation by using pulse oximetry as well as appropriate management of a positive screening result. The AAP is committed to the safe and effective implementation of pulse oximetry screening and is working with other advocacy groups and governmental agencies to promote pulse oximetry and to support widespread surveillance for CCHD.
Going forward, AAP chapters will partner with state health departments to implement the new screening strategy for CCHD and will work to ensure that there is an adequate system for referral for echocardiographic/pediatric cardiac evaluation after a positive screening result. It is imperative that AAP members engage their respective policy makers in adopting and funding the recommendations made by the Secretary of HHS.
Towards a neuroimaging biomarker of depression vulnerability
Authors: Farb Norman , Segal Zindel , Anderson Adam 
Published: December 2011

AbstractMajor depressive disorder (MDD) is a pervasive and debilitating illness, with a recurrent course and chronic prognosis. Although effective treatments for MDD exist, there is a pressing need to characterize relapse vulnerability in order to design effective prophylactic care. To date, heterogeneity within depression neuroimaging research has made it difficult to establish a reliable biomarker of disorder susceptibility. In this paper, we review neuroimaging evidence for the assessment of MDD vulnerability, theorizing that current findings can be broadly distinguished between those indicating the presence of depressive episodes and those indicating MDD vulnerability during symptom remission. We argue that unlike the amygdala hyperactivity and prefrontal hypoactivity observed during MDD episodes, prefrontal hyperactivity may be a characteristic of dysphoric cognition during symptom remission that indicates MDD vulnerability and relapse risk. Drawing on current research of normative emotion regulation, we describe a potential test of MDD vulnerability, employing emotional challenge paradigms that induce cognitive reactivity — the increased endorsement of negative self-descriptions during a transient dysphoric mood. Relative to a normative model of prefrontal function, the neuroimaging assessment of cognitive reactivity may provide a reliable indicator of MDD vulnerability, advancing the field of biomarker research as well as the delivery of preventative treatment on an individual basis.
Stem cell therapy for neurological disorders
Authors: Baronica Koraljka , Friedrich Latica 
Published: December 2011

AbstractStem cells have long been in focus as potential therapy or even cure for a whole myriad of diseases. Many neurodegenerative disorders, both acute and chronic, are characterized by irreversible neuronal damage and loss, and only a few efficient treatment options exist. In contrast to many other tissues, the potential of self-regeneration of the central nervous system is highly limited. There is hope that stem cells could replace the damaged neuronal and glial cells, and provide biological and functional restoration based on their properties of self renewal and the ability to give rise to different cells. In recent years, the promising results of research on animal models has led to the establishment of the first clinical trials; although no clear evidence of therapeutic benefit for any of the conditions have been ascertained. Here we give a review of the current strategies of stem-cell based therapy for some of the more common neurological disorders, discussing the progress and current challenges, and giving an overview of future perspectives.
Heterosis Of Yield And Its Contributing Characters Of T-Aman Rice (<i>Oryza Sativa</i> L)
Authors: Roy PC , Rasul MG , Mian MAK , Molla MAH 
Published: December 2011

The investigation was undertaken to study heterosis over better parent, heterosis over mid parent, reciprocal effects in eight crosses, their reciprocals and parents of T-Aman rice genotypes. Maximum traits showed heterosis in desirable direction of which the hybrid FR-13A × Arman sarder performed the best towards shorter stature, yield components like tiller number, panicle length, filled grains per panicle and 100-grain weight. The hybrid FR-13A × PJT (st) showed significant and positive heterosis over better parent for plant height, number of tillers per hill, grains per panicle and yield per hill which performed the best in terms of both physical as well as yield contributing traits. Considering heterosis over mid parent, the hybrid FR-13A × Arman Sarder performed the best showing heterosis in desirable direction on maximum number of traits namely tiller number, panicle length, filled grains per panicle, harvest index and yield per tiller. Most of the hybrids showed maternal effects but the cross FR-13A × PJT (st) had no maternal effects for 100 grains weight. Key words: Rice; heterosis; better parent; mid parent; reciprocal effectDOI: http://dx.doi.org/10.3329/bjpbg.v23i1.9311BJPBG 2010; 23(1): 1-7
Heterosis in Local Boro Rice (<i>Oryza sativa</i> L.)
Authors: Islam MM , Sarker U , Rasul MG , Rahman MM 
Published: December 2011

An experiment was conducted to study the heterosis of 27 F1 hybrids produced from nine CMS lines and three restorer lines of rice with their parental lines and BRRI Dhan29 as standard check for 17 yield and its contributing traits. Mid parent, better parent and standard heterosis of most of the crosses were significant for most of the characters studied either in positive or in negative direction. Desirable and significant mid parent and better parent heterosis was observed in 13 and seven cross combinations, respectively for grain yield and most of its related traits. Considering more than 20% mid parent and better parent heterosis for grain yield along with most of its related traits, nine and five cross combinations, respectively were identified as good heterotic combinations over mid parental and better parental value. On the basis of individual trait significant and desirable mid parent heterosis was observed in eight cross combinations for plant height, 12 for leaf blade length, nine for flag leaf blade length, 13 for flag leaf sheath length, eight for tillers per hill, eight for panicles per hill, 14 for days to 50% flowering, four for days to maturity, four for panicle length, 14 for panicle weight, nine for primary branches per panicle, 16 for secondary branches per panicle, six for filled grains per panicle, 15 for 1000 seed weight, 13 for grain yield per hill and 15 for harvest index. Significant and desirable better parent heterosis was observed in 12 cross combinations for plant height, 11 for leaf blade length, 5 for flag leaf blade length, nine for flag leaf sheath length, seven for tillers per hill, seven for panicles per hill, 25 for days to 50% flowering, one for days to 100% flowering, seven for days to maturity, three for panicle length, nine for panicle weight, five for primary branches per panicle, 12 for secondary branches per panicle, four for filled grains per panicle, nine for 1000 seed weight, seven for grain yield per hill and nine for harvest index. None of the crosses were identified as good heterotic over standard check for grain yield per hill but many good and desirable heterotic crosses were identified over standard check for most of the yield related characters. Twenty cross combinations were identified as heterotic over standard check due to desirable and significant standard heterosis for most of the yield related traits. Keywords: Heterosis; rice; Oryza sativa; boro DOI: http://dx.doi.org/10.3329/bjpbg.v23i1.9314 BJPBG 2010; 23(1): 19-30
Variability And Character Association Of Reproductive Traits In Exotic Rice Germplasm
Authors: Akhter T , Ivy NA , Rasul MG , Mian MAK 
Published: December 2011

Fifty two genotypes were evaluated to find out the genetic variability, character association, and path coefficient for reproductive traits of exotic rice germplasm in experimental field of Bangabandhu Sheikh Mujibur Rahman Agricultural University, Salna, Gazipur during December 2008 to May 2009. The analysis of variance showed significant variation for all the characters indicating wide genetic variability among the genotypes. The highest genotypic variance and phenotypic variance were found for pollen sterility and filled grains per panicle. High heritability and genetic advance were recorded for pollen sterility. Filled grains per panicle, days to 50% flowering, and pollen sterility of different genotypes had a high degree of significant positive association with grain yield per hill. On the basis of genetic parameters, associations and path analysis 52 genotypes might be selected considering the filled grains per panicle only. Key words: Variability; correlation coefficient; path coefficient; exotic rice DOI: http://dx.doi.org/10.3329/bjpbg.v23i1.9316 BJPBG 2010; 23(1): 39-44
Combining Ability And Heterosis In Snakegourd (<i>Tricosanthes Cucurminata</i> L)
Authors: Podder R , Rasul MG , Islam AKMA , Mian Mak , Ahmed JU 
Published: December 2011

A half diallel set of five parents and their 10 F1’s were studied to determine the combining ability and magnitude of heterosis for eight important characters in snakegourd at the experimental field of Bangabandhu Sheikh Mujibur Rahman Agricultural University during April to July, 2004. Combining ability analysis revealed that both general and specific combining ability variances were significant for all the characters except fruit diameter and fruit yield per plant. Predominance of additive gene action was noted for all the characters except days to first female flower where non-additive gene action was predominant. Parent P1 was the best general combiner for fruit yield and some yield contributing characters. Among the crosses P2 X P3, P1 X P2 and P1 X P4 were the best specific combiner for fruit yield and some of yield contributing characters. Both positive and negative heterosis was obtained of which few hybrids showed desirable and significant values. P2 X P5 showed the highest significant mid parental heterotic value for earliness and high yield whereas, P1 X P2, P2 X P3, P2 X P5 and P3 X P4 showed the highest significant better parent heterotic effect for earliness and high yield. Key words: Snakegourd (Trichosanthes cucurminata L.); combining ability; heterosis; fruit yieldDOI: http://dx.doi.org/10.3329/bjpbg.v23i2.9318 Bangladesh J. Pl. Breed. Genet., 23(2): 1-6, 2010
Genetic Variability And Selection Response To Heat Tolerance Through Membrane Thermostability In Spring Wheat (<i>Triticum Aestivum</i> L)
Authors: Barma NCD , Islam MA , Hakim MA , Sarker DKR 
Published: December 2011

The present investigation was undertaken to study the genetic variability and selection response of heat tolerance measured through membrane thermostability (MTS) in F2 derived F4 and F5 generations of five wheat crosses: Kanchan × Gourab, Gourab × Fang 60, Kanchan × Pavon 76, Gourab × Pavon76 and Fang 60 × Pavon76. Each cross was consisted of 65, 60, 77, 72 and 64 F4 bulks including two parents. The study was conducted both in the field and laboratory of Wheat Research Centre, Dinajpur during 2002-03 and 2003-04. A completely randomized design for laboratory experiment and randomized complete block design for field experiments was followed with three replications. Acquired thermal tolerance through Membrane Thermo-stability assay was performed in controlled environment as per method described by Ibrahim and Quick (2001). Other morpho-physiological traits were measured from field experiment. The crosses Kanchan × Gourab, Kanchan × Pavon 76 and Fang 60 × Pavon76 showed high genetic variability with high population mean for MTS in F4 bulks. These crosses also exhibited high-observed response to selection, realized heritability and heritability in standard unit indicating expected good gain through early generation selection. Direct response to selection for this trait was significant in these crosses in F5 generation. Direct selection for MTS significantly improved biomass, grain yield, thousand grain weight, grain filling rate and canopy temperature depression in crosses Kanchan × Pavon 76, Gourab × Pavon76 and Fang 60 × Pavon76 with few exceptions. Direct selection of MTS also improved chlorophyll retention at 21 days after anthesis in crosses Gourab × Fang 60 and Gourab × Pavon76. Significant intergeneration correlations (F4 vs. F5) were observed for MTS in all five crosses studied indicating possibility of effective improvement of this trait through selection in early generation. Key words: Membrane thermostability; selection response; realized heritability; intergeneration correlation.DOI: http://dx.doi.org/10.3329/bjpbg.v23i2.9320 Bangladesh J. Pl. Breed. Genet., 23(2): 15-22, 2010
Genetic Variability And Character Associations In Irrigated Rice (<i>Oryza Sativa</i> L)
Authors: Ghosal S , Biswas PL , Khatun M , Khatun S 
Published: December 2011

Eighteen advanced breeding lines were evaluated for yield and yield contributing characters to observe their variability, associations and direct and indirect effect on yield during Boro season, 2009. All the tested characters showed significant variation. Effective tillers/m2 and spikelet sterility (%) had high genotypic variance, high heritability, high genetic advance and high genotypic coefficient of variation. Effective tillers/m2, panicle length (cm), thousand grain weight (g) and growth duration (days) showed significant positive association with grain yield. Path coefficient analysis also revealed that effective tillers/m2, thousand grain weight (g) and growth duration (days) had higher direct effects on yield (t/ha). All together with the genetic variability, correlation and path analysis revealed that effective tillers/m2, thousand grain weight (g) and growth duration (days) are the most important yield components in rice. Therefore, from the present study it could be suggested that emphasize should be given on these characters for the selection of genotypes for higher grain yield in irrigated rice. Keywords: Rice (Oryza sativa L.); GCV; PCV; heritability; genetic advance; correlationDOI: http://dx.doi.org/10.3329/bjpbg.v23i2.9321 Bangladesh J. Pl. Breed. Genet., 23(2): 23-27, 2010
Genectic Variability In Some Maintainer Lines Of Hybrid Rice (<i>Oryza sativa</i> L)
Authors: Ansari A , Rasul MG , Biswas PL , Paul AK , Rahman MH 
Published: December 2011

Twelve maintainer lines of rice were evaluated for 19 agronomic characters in a randomized complete block design to study the genetic divergence through multivariate analysis. Genotypes were grouped into three different clusters. Cluster I comprised maximum number of genotypes (ten) and II and III contain only single genotype each. PCA showed 70.29% variation against first three eigen values. The highest inter genotypic distance was observed between the genotype BRRI 1B and IR 73328B (2.278) followed by BRRI 3B and IR 68890B (2.229) and the lowest distance was observed (0.752) between genotypes BRRI 10B and IR 78355B followed by the distance (0.920) between genotypes BRRI 3B and IR 58025B. The inter cluster distance was larger than the intra cluster distances. The highest inter-cluster distance was observed between cluster II and III (7.113). The lowest inter-cluster distance was observed between cluster I and II (4.445) followed by cluster I and III (4.509). The inter cluster distances were higher than the intra cluster distances suggesting wider genetic diversity among the genotype of different groups. Among the characters anther length (0.00651), stigma length (0.00150), days to maturity (0.03018), number of tillers per hill (0.07890) and panicle weight (0.12713) were major characters that contribute to the genetic divergence. Key words: Rice; maintainer line; genotype; genetic divergence; D2DOI: http://dx.doi.org/10.3329/bjpbg.v23i2.9323 Bangladesh J. Pl. Breed. Genet., 23(2): 35-40, 2010