bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-N‐Methyl‐D Receptor Encephalitis During Long-Term Adalimumab Therapy for Crohn's Disease
Authors: MacKay Scott , Salh Baljinder 
Published: May 2024

ABSTRACT
A 46-year-old woman with fistulizing Crohn's disease in clinical remission in the setting of long-term adalimumab therapy presented to hospital and was ultimately diagnosed with anti‐N‐methyl‐D (NMDA) receptor antibody-mediated autoimmune encephalitis (NMDAr-AE). Inflammatory central nervous system and antibody-mediated adverse effects have been found to be associated with anti–tumor necrosis factor agents, with 5 previous case reports noting cases of NMDAr-AE in patients on these medications. The current article reports this case, which is unique for the length of adalimumab therapy before this presentation, as well as a summary of literature regarding anti–tumor necrosis factors and NMDAr-AE.
Analisis Mengenai Hubungan Obesitas, Aktivitas Fisik, dan Stres Kerja Dengan Kejadian Hipertensi Pada Guru SMA Negeri di Kecamatan Kota Kabupaten Sumenep
Authors: Imamah Syarofatul , Prasetyowati Irma , Antika Ruli Bahyu 
Published: May 2024

Hypertension is known as "The Silent Killer" and causes many deaths. Riskesdas 2018 stated that hypertension in the population aged 18 increased from 26.2% in 2013 to 36.3% in 2018. Based on data from the Sumenep Health Office, it was stated that the prevalence of hypertension has increased from 2019 to 2020. This study aims to analyze the association between obesity, physical activity, and work stress with the incidence of hypertension among high school teachers in the Sub-District of Sumenep Regency. This research was a quantitative analytic study with a cross-sectional research design. Respondents in this research were high school teachers in the Sub-District of Sumenep Regency. The sample was 59 respondents used the multistage random sampling technique with proportional random sampling and simple random sampling. This research used sphygmomanometer digital, scales, microtoice, Baecke Questionnaire, and HARS (Hamilton Anxiety and Rating Scale). The analysis used was Chi-Square test. Based on the study's result, it can be concluded that physical activity (p-value = 0.039) is associated with the incidence of hypertension in high school teachers. There was a significant association between physical activity and the incidence of hypertension in high school teachers.
Comparative toxicity assessment of fisetin-aided artificial intelligence-assisted drug design targeting epibulbar dermoid through phytochemicals
Authors: Naveed Muhammad , Abid Amina , Aziz Tariq , Saleem Ayesha , Hanif Nimra , Ali Imran , Alasmari Abdullah F. 
Published: May 2024

Abstract
Epibulbar dermoid, benign tumors resulting from the improper function of the pathogenic protein Patched 1 (PTCH1), surgical interventions are employed to mitigate the lethal effects. However, these procedures often lead to complications such as scleral weakening and corneal astigmatism. Due to the absence of effective medical treatments, there is a critical need for novel approaches to prevent the spread of this disease. This study not only fills a key gap in medical therapy for epibulbar dermoid, but it also demonstrates AI’s transformational potential in drug development. Employing an AI drug design service, three efficient de novo therapeutic compounds targeting the PTCH1 protein were crafted with Fisetin. The method included obtaining the PTCH1 protein sequence from NCBI, computing physiochemical parameters with Expasy Protparam, and estimating the 3D structure with SWISS-MODEL. Quality assessment, binding site prediction, drug design with WADDAICA, Lipinski’s Rule of 5, toxicity screening, ADMET evaluation, docking analysis with CB-dock and Patch dock, and MD simulations with IMOD all work together to provide an adequate basis for the development and validation of AI-designed phytochemical medicines for epibulbar dermoid. Comprehensive pharmacokinetic and toxicity assessments demonstrated the outstanding absorbency of AI-designed Fisetin in the blood–brain barrier, emphasizing its non-toxic nature. The AI-designed Fisetin exhibits a notable affinity of approximately −9.2 kcal/mol during docking with the PTCH1 protein, suggesting its potential as a drug. While the in silico results indicate efficiency and safety, the necessity for in vivo testing is acknowledged to validate these promising findings. This research significantly advances the frontier of knowledge by proposing a non-invasive solution to epibulbar dermoid, addressing current limitations, and offering potential alternatives to conventional surgical interventions.
Selection of Euler deconvolution solutions using the enhanced horizontal gradient and stable vertical differentiation
Authors: Pham Luan Thanh , Oliveira Saulo Pomponet , Abdelrahman Kamal , Gomez-Ortiz David , Nguyen Dat Viet , Vo Quynh Thanh , Eldosouky Ahmed M. 
Published: May 2024

Abstract
Euler deconvolution is widely used for interpreting magnetic anomalies as it estimates the edges and depths of magnetic sources. Since this method was proposed, there has been an intensive effort to mitigate its primary deficiencies, namely, the generation of many spurious solutions and the high noise sensitivity. To select the most significant solutions, we adopt the strategy of constraining the moving window to the source edges, whose locations are estimated using the enhanced horizontal gradient amplitude method. On the other hand, we reduce noise propagation by performing a stable calculation of the vertical derivatives. For this purpose, we use the β-VDR method, a finite-difference method that yields a robust approximation of the vertical derivatives of magnetic data. The accuracy of the proposed technique is demonstrated on synthetic magnetic anomalies, providing the depths more precisely and being insensitive to noise. Application of this technique is also demonstrated on aeromagnetic anomalies from the Olympic Peninsula (USA), where the obtained result is in good agreement with known information of the study region.
Evaluating fetal tricuspid and mitral annular plane systolic excursion (TAPSE and MAPSE) using spatiotemporal image correlation (STIC) M-mode
Authors: Avnet Hagai , Thomas Samantha , Erenbourg Anna , Yagel Simcha , Welsh Alec 
Published: May 2024

Abstract

Objectives
This study aimed to evaluate the feasibility and reliability of tricuspid and mitral annular plane systolic excursion measurements (TAPSE and MAPSE) applying M-mode spatiotemporal image correlation (STIC) technology in low-risk pregnancies.

Methods
An initial retrospective pilot study was carried out to assess repeatability, followed by a larger mixed cross-sectional and prospective longitudinal study, both evaluating low-risk singleton pregnancies between 22+6 and 39+1 weeks. As only annuli capture was necessary, STIC acquisition parameters were set to the minimum volume angle of 15° and acquisition time of 7.5 s.

Results
A total of 330 volumes were analysed offline applying STIC M-mode. Acquisition rates were 96.9 % for TAPSE and 93.7 % MAPSE in the pilot study (n=32) and 98.0 % for both in the longitudinal study (n=102). Both study designs revealed good repeatability for both sides of the heart, with higher intraclass correlation coefficients (ICCs) for TAPSE (0.84–0.94) compared to MAPSE (0.80–0.88). Good repeatability was demonstrated for both sides of the heart, more so for TAPSE than MAPSE, with ICCs for TAPSE 0.84–0.91 and MAPSE 0.75–0.76, comparable to prior ICCs for STIC repeatability.

Conclusions
Modified STIC acquisition settings specifically tailored for capturing the longitudinal annular displacement may improve STIC TAPSE and MAPSE acquisition rates, optimising image quality for precise measurement and potentially bringing these modalities closer to clinical application.
Agricultural Information Needs and Resources of Smallholder Sugarcane Farmers in Swaziland
Authors: Dlamini Nkosinathi M. , Ngulube Patrick 
Published: May 2024

Abstract
The sugar industry is the dominant agricultural sector in Swaziland’s economy, contributing significantly to the gross domestic product. Provision of relevant and timely information to smallholder sugarcane farmers is crucial for them to have a competitive footing with large-scale counterparts and reduce poverty. However, there is limited literature on the information needs and the kind of information communication resources that could make the dissemination of information to farmers efficient and effective. This study thus aims to investigate the information needs and resources of smallholder sugarcane farmers in Swaziland to inform the provision of information services in the sugar industry. It was underpinned by a positivist paradigm and used the survey research method complemented by methodological triangulation to collect quantitative and qualitative data. Data was collected using survey questionnaires and face-to-face interviews, with 168 responses and six interviews conducted. The findings revealed that 71 % of information needs of farmers were primarily in legislative compliance, sugarcane crop husbandry, markets and transport, and financial advice information, however, there were no statistically significant differences between the three mill groups in information needs. The smallholder sugarcane farmers also mostly obtained agricultural information through extension officers, farmer groups, and mobile phones, indicating that required information was mainly accessed through face-to-face interactions. The empirical findings of the study have implications for practice, policy, and theory with respect to guiding the implementation of agricultural information services by information providers in the context of rural farmers in developing countries.
Construction of Intellectual Property Literacy Education Mode in University Libraries
Authors: Lei Qin , Tian Yajuan 
Published: May 2024

AbstractThe importance and urgency of IPLE (intellectual property literacy education) are increasingly prominent. This paper aims to build an IPLE mode to provide support for the talent cultivation in university libraries facing opportunities and challenges in the service transformation period. The IPLE mode and content of the Regional Patent Information Centers (PIZ Regional Centers) in German universities and university libraries are studied through network research, literature research, and comparative analysis. Based on the practical experience, educational characteristics and advantages, this paper constructs an IPLE mode of university library that includes six modules. Building the IPLE mode of university libraries can provide reference for university libraries in the work of IPLE, and gradually form an IPLE system that meets the needs of users’ training, conforms to the university’s talent training objectives, and improves the development plan of the university libraries.
Diversified Reward-Risk Parity in Portfolio Construction
Authors: Choi Jaehyung , Kim Hyangju , Kim Young Shin 
Published: May 2024

Abstract
We introduce diversified risk parity embedded with various reward-risk measures and more generic allocation rules for portfolio construction. We empirically test the proposed reward-risk parity strategies and compare their performance with an equally-weighted risk portfolio in various asset universes. The reward-risk parity strategies we tested exhibit consistent outperformance evidenced by higher average returns, Sharpe ratios, and Calmar ratios. The alternative allocations also reflect less downside risks in Value-at-Risk, conditional Value-at-Risk, and maximum drawdown. In addition to the enhanced performance and reward-risk profile, transaction costs can be reduced by lowering turnover rates. The diversified reward-risk parity allocations gain superior performance in the Carhart four-factor analysis.
What patient positioning in chest X-ray is still acceptable? – An empirical study on thresholding quality metrics
Authors: von Berg Jens , Hergaarden Kenneth F. M. , Englmaier Max , Pfeiffer Daniela , Wieberneit Nataly , Krönke-Hille Sven , Harder Tim , Gooßen André , Bystrov Daniel , Brueck Matthias , Young Stewart , Lamb Hildo J. 
Published: May 2024

AbstractBackground and AimIssues in patient positioning during chest X-ray (CXR) acquisition impair diagnostic quality and potentially increase radiation dose. Automated quality assessment was proposed to address this. Our objective is to determine thresholds on some quality control metrics following international guidelines, that represent expert knowledge and can be applied in a comprehensible and explainable AI approach for such an automatic quality assessment.Materials and MethodsAn AI-method estimating collimation distance to the ribcage, balancing between both clavicle heads, and number of ribs above the diaphragm as metrics for collimation, rotation, and inhalation quality was applied on 64,315 posteroanterior CXR images from a public dataset (ChestX-ray8). From this set 920 CXR images were sampled and manually annotated to gain additional trusted reference metrics. Seven readers from different institutions then classified the acquisition quality of these images independently into okay, inadequate, or unacceptable following the criteria of international guidelines. Optimal thresholds on the metrics were determined to reproduce these classes using the metrics only.ResultsA fair to moderate agreement between the experts was found. When disregarding all inadequate rates a classification on the metrics was able to separate okay rated cases from unacceptable cases for collimation (AUC 0.97), rotation (AUC = 0.93) and inhalation (AUC = 0.97).ConclusionSuitable thresholds were determined to reproduce expert opinions in the assessment of the most important quality criteria in CXR acquisition. These thresholds were finally applied on the AI-method's estimates to automatically classify image acquisition quality comprehensibly and according to the guidelines.
Seroprevalence of Hepatitis A virus and Hepatitis E virus in patients presenting with acute viral hepatitis: A retrospective study of 2-years at tertiary care Hospital, Himachal Pradesh in Northern India
Authors: Sharma Ankita , Kumar Narender , Sood Anuradha 
Published: May 2024

: Hepatitis-A virus and Hepatitis-E virus are spread enterically, resulting in acute viral hepatitis (AVH) in developing countries. Fecal-oral transmitted hepatitis cause major health problems in our country. The aim of present study is to determine the seroprevalence of HAV and HEV in AVH patients attending the tertiary care hospital at Dr. Rajendra Prasad Govt. Medical College Kangra at Tanda, Himachal Pradesh (DRPGMC). Insufficient data makes it difficult to determine an accurate prevalence of illness in this region of India.: The Viral Research and Diagnostic Laboratory (VRDL), in the Department of Microbiology at DRPGMC Tanda, Himachal Pradesh, consolidated retrospective data of 2-years duration. The study population included 784 serum samples received from outdoor and indoor patients were considered in the study.: Of the 784 serum samples that were chosen for our study, HAV and HEV reactive patients showed a seroprevalence of 11.20% and 1.80% respectively. During two years of the study, the co-infection rate of HAV and HEV in patients with acute viral hepatitis was 0.5%. Compared to females (31.80% and 42%), males reported higher seroprevalence of HAV (68.10%) and HEV (57.10%). Further data shows that HAV infection was observed in all age groups and the highest prevalence was reported in the age range from 11 to 20 years. The HEV infection was not observed in the pediatric age groups, it was only observed in adults. Maximum prevalence of HEV was reported in the age group of 21-30 years. The highest number of reactive cases was recorded in the month of August and September.: We found that the prevalence of HAV is significantly higher than that of HEV during two years of study period. In this study, we observed that HAV is more predominant in males as compare to females.HEV infections were only observed in adults.
Development of powder delivery nozzles for laser gas-powder cladding
Authors: Anyakin Mykola , Yao Jianhua , Zhang Qunli , Zhuk Ruslan , Chen Zhijun , Vintoniak Sergiy , Kupchak Denis 
Published: May 2024

Along with processing parameters, material properties of the workpiece and the powder, the quality of focusing of gas-powder stream is the key parameter that can influence the productivity, quality and costs of laser gas-powder cladding, rapid prototyping by selective laser sintering and surface modifications. Unfortunately, there is almost no information on the methodology for the design of gas-powder streams delivery and simple methods for the control and measurement of gas-powder stream characteristics.Development of the methodology for the design gas-powder streams delivery nozzles that are used in laser gas-powder cladding and simple methods for the control of gas-powder stream characteristics.Numerical methods of vector optics, gas dynamics and image analysis were used.Original systems for the implementation of laser gas-powder cladding with increased productivity and low rate of powder waste were designed, manufactured and verified experimentally.It was established that the use of multi-channel nozzles for the delivery of gas-powder stream into laser beam processing zone increase the productivity of technological processes of laser cladding (especially for the cases when workpiece is not positioned perpendicularly to the laser beam) if compared with traditional coaxial and one-channel nozzle. Another benefit of multi-channel nozzles is that it is possible to introduce simultaneously two or more different powder mixtures into the processing zone.
Quantitative fishery assessment in tropical waters: Stock dynamics and strategy options
Authors: J. Jayasankar  , Eldho Varghese  , A. Gopalakrishnan  , E. Vivekanandan  , U. Ganga  , Prathibha Rohit  , V. Sreepriya  , Judith Das  
Published: May 2024

This paper explores the possible options for quantitative fishery stock assessment in tropicalwaters and is composed of four layers viz., concepts, methodologies, data and indicators.The concept promotes the fundamental theory that has been popular in research on stockdynamics, including the possibility of combining it with various doses of intrinsicallybiological information, from individual fish to regional stocks. After reviewing the concepts,tools and their evolution, an attempt has also been made to propose a few guidelines as thebest ways to approach stock assessment and formulate input control or output regulationstrategies in the most pragmatic yet scientific manner, thereby ensuring minimal impact onthe fishery, fishers and stocks in the medium term.

Keywords:Bayesian approach, Capture fisheries, Fish stockassessment, Models
Morphometry and length-weight relationships of the freshwater pearl mussel Parreysia corrugata (Muller 1774) (Bivalvia: Unionidae) from Daya River, Odisha, India
Authors: E. M. Chhandaprajnadarsini  , Saurabh Shailesh , Pankaj Kumar Tiwari  
Published: May 2024

Allometry in the freshwater mussel Parreysia corrugata was studied from east-flowing riverDaya, Bhubaneswar, India. The results indicated that shell length (SL)-shell height (SH) andshell length-shell width (SW) relationships for P. corrugata were SH = 0.876 + 0.932SL andSW = 0.625 + 0.898SL. Greater correlation was found between SL and SW than between SLand SH. The length-weight, height-weight and width-weight relationships of P. corrugata wereestablished as TW = 0.00038SL2.80, TW = 0.0006SH2.95 and TW = 0.0023SW2.97 respectively.The t-test value of b indicated an isometric growth pattern in the width-weight and theheight-weight relationships. The highest r2 value was obtained for shell length-total weightand shell height-total weight equations. Present study will be helpful in strengthening theknowledge on interrelationship between the morphometric variables of P. corrugata and alsoin comparing with the earlier studies to know the existence of spatial or temporal variabilityin the morphometry of this species. This information can also be used to better understandthe biology of P. corrugata and to improve the management of this species.

Keywords:Conservation, Daya River, Length-weight relationships,Morphometry
Study on Plugging the Multiscale Water Channeling in Low-Permeability Heterogeneous Porous Media Based on the Growth of Bacteria
Authors: Zhang Lei , Ni Jun , Wang Chengjun , Li Chengyong , Cui Kai 
Published: May 2024

Summary
To promote the effect of waterflooding of a heterogeneous low-permeability reservoir in the Ordos Basin, a microbial plugging agent is developed to plug the multiscale water channeling. Based on the characteristics of the growth of bacteria, the microbial plugging agent can plug both porous media and microfractures with different scales. The microbial plugging agent is prepared by activating the native bacteria present in low-permeability reservoirs by using the fermentation nutrients. After growing in the fermentation nutrient solution for 4 days in a beaker, the growth of microbial strains begins to stabilize. After that, the main particle size of the prepared microbial plugging agent is between 40 μm and 160 μm and the median particle size (D50) is near 90 μm. The microbial plugging agent has good shear resistance, salt resistance, and stability. At the initial state, due to good injectivity, the microbial plugging agent can smoothly enter into a low-permeability core, a heterogeneous core, and a fractured core, respectively. Thus, it can grow and reproduce in the cores. Based on the characteristics of growth, it can match with the spatial scale of pore or fracture in the cores, so that it cannot only plug the porous media water channeling with different scales but also plug the microfracture water channeling with different scales. This phenomenon has been confirmed by microscopic visualization flow experiments and core flow experiments. The developed microbial plugging agent can be applied to plug the multiscale water channeling to enhance oil recovery of low-permeability heterogeneous reservoirs.
The Use of the Target Trial Approach in Kidney Disease: A Methodological Systematic Review Protocol
Authors: Pinter Jule , Tunicliffe David , Karunaikumar Pooshwikaa , Anastasiadis Anastasios , Hills Robert K. 
Published: May 2024

Abstract

Background
Patients with kidney disease and failure have often been excluded from randomized trials leaving practitioners with limited data to navigate their decision-making at critical stages of patient’s lives.
The concept of target trial emulation has recently been introduced and implemented in Nephrology to address critical questions in the comparative effectiveness and safety of interventions during kidney failure. However, the reach, validity, and application of trial emulation in nephrology remains unknown and warrants systematic investigation. This methodological systematic review protocol aims to describe the methodology for assessing the available evidence regarding emulated target trials for studying outcomes in patients with kidney disease.
Methods
This protocol is developed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) statement. MEDLINE, Embase, and reference lists will be searched up until 1st July 2023 to identify all studies in kidney disease patients that use target trial emulation as the primary approach for analysis. Two authors (AA, PK) will select articles based on title and abstract and then full text, with a third reviewer settling disagreements (JP). Prespecified variables will be extracted, and risk of bias assessed using prespecified data forms to determine, how robust the target trial design, emulation and answer is.
Discussion
The aim of this methodological systematic review is to understand the extent to which the target trial approach is being used in kidney disease, and to make recommendations for improving its use in nephrology.
Methodological systematic review registration
OSF, https://osf.io/z4y29 (under embargo currently).