bluuebunny/crossref_metadata_2025_split huggingface dataset:
Access Flow Reduction and Recurrent Symptomatic Cephalic Arch Stenosis in Brachiocephalic Hemodialysis Arteriovenous Fistulas
Authors: Arthur Miller Gregg , Friedman Alexander , Khariton Aleksandr , Preddie Dean C. , Savransky Yevgeny 
Published: November 2010

Background Recurrent cephalic arch stenosis (CAS) has been linked to high flow and has a high rate of recurrence following angioplasty. This study investigates the effectiveness of access flow reduction in decreasing rapidly recurrent symptomatic CAS. Methods A retrospective study of patient records from February 2005 to April 2009 was conducted. Patients with brachiocephalic fistulas who had undergone two or more instances of cephalic arch angioplasty within 3 months, and thereafter underwent flow reduction via banding of the access inflow (n=33) were included. A before-and-after analysis was conducted: the rates of cephalic arch angioplasty were calculated for each patient before and after the banding procedure, and compared via a paired t-test. Results At 3, 6, and 12 months, the cephalic arch primary lesion patency was 91%, 76%, and 57%. The cephalic arch intervention rate was reduced from 3.34 to 0.9 per access-year (t=7.74, p<.001). The average follow-up time was 14.5 months (range, 4.8–32). Conclusion Flow reduction of a brachiocephalic arteriovenous hemodialysis fistula may effectively diminish the incidence of symptomatic CAS.
Optimizing Hemodialysis Arteriovenous Fistula Maturation
Authors: Falk Abigail 
Published: November 2010

Purpose To review why hemodialysis fistulas fail to mature and how percutaneous techniques can salvage them. Methods A review of the medical literature was performed, with specific attention to the location of the lesions, the types and the numbers of procedures performed, salvage and patency rates. Results Using balloon angioplasty of the arteries and/or veins with sequential dilation if needed and ligation or embolization of collateral side branches the fistula that has failed to mature can be salvaged. Usually, more than one procedure is required to salvage a fistula; however, salvage rates of 75–95% are achieved with 1 yr primary patency rates of 30–60%. With repeat percutaneous interventions, 1 yr secondary patency rates are 75–90%. Conclusions With surveillance and aggressive follow-up after placement, early intervention (primarily dilation in the access circuit) can yield high salvage rates in fistulas that fail to mature.
Treatment of Dialysis Access-associated Steal Syndrome with the “Revision Using Distal Inflow” Technique
Authors: Callaghan Chris J. , Mallik Mekhola , Sivaprakasam Rajesh , Iype Satheesh , Pettigrew Gavin J. 
Published: November 2010

Purpose Dialysis access-associated steal syndrome (DASS) is a common, serious complication of antecubital fossa (ACF) arteriovenous fistulas (AVFs). We describe our experience of the “revision using distal inflow” (RUDI) technique for the treatment of DASS and review the literature. Methods Patients underwent fistula ligation at the anastomosis with re-establishment of inflow via the proximal radial or ulnar arteries using a venous interposition graft or venous collateral. A retrospective analysis of outcomes of all patients undergoing this procedure at our center was carried out. Results Seven patients with autogenous ACF AVFs underwent the RUDI procedure, four under local anesthesia. Interposition vein grafts were used in five patients, and inflow was achieved through the proximal radial artery in four cases. The median post-operative rise in digital systolic blood pressure was 65.5 mmHg. Follow-up at 7–36 months found that three fistulas had failed (one at 8 months, two within days), two patients had died with patent fistulas, one patient was transplanted with a functional AVF, and the remaining patient continues to dialyze through the fistula. No patients developed DASS postoperatively and no further interventions were required to maintain patency. Conclusions Although RUDI was successful at treating DASS, a high rate of AVF failure was seen. With technical modifications and further experience, RUDI may become a valuable tool in the surgical armamentarium.
Preclinical Results of a Prosthetic, Early-Stick Graft with Functional Endothelium
Authors: Hashi Craig K. , Glickman Marc H. 
Published: November 2010

Purpose The purpose of this study was to evaluate the NanoVasc Vascular Graft in comparison with a marketed expanded polytetrafluoroethylene (ePTFE) graft, both in vitro and in vivo. The graft was evaluated for use as both a bypass and arterio-venous (AV) access graft. Early-stick capabilities and patency were the primary end points evaluated. Methods Third party, independent laboratories completed mechanical testing, biocompatibility, and preclinical data collection. An ovine carotid artery interposition model and a canine femoral AV access model were used to evaluate 5–mm and 6–mm internal diameter sizes, respectively. Results There was no statistical difference in either model between the NanoVasc and ePTFE grafts with respect to patency. Time to hemostasis after cannulation with a 16–gauge needle was achieved ~10 times faster with the NanoVasc graft (mean time 27 seconds) compared with ePTFE. Histological analysis demonstrated functional endothelialization (nitric oxide expression), positive wound healing (cellular infiltration into the wall of the graft), and hemocompatibility of the NanoVasc graft. Conclusions The NanoVasc Vascular Graft is a strong candidate as a bypass and AV access graft. Its early-stick capabilities and patency rates are an attractive feature in comparison with current AV access grafts.
Prospective Clinical Evaluation of the Polyperf® Safe, a Safety Huber Needle, in Cancer Patients
Authors: Goossens Godelieve A. , Moons Philip , Jérôme Martine , Stas Marguerite 
Published: November 2010

Purpose Evaluation of the Polyperf® Safe (PPS) needle on safety and user-friendliness, as experienced by first-time and non-first-time users of the device. Methods A prospective, descriptive study was carried out at the University Hospitals Leuven, Belgium. Five hundred PPS needles were individually evaluated in cancer patients. Different aspects of the PPS were assessed: packaging, needle insertion, and needle removal. Nurses were asked whether they had previously inserted or removed this type of needle. We compared the PPS needle with the standard Gripper® needle in terms of safety, ease of use, and ease of training. Results Three hundred sixty-six evaluation forms were available for analysis (73.2%). Packaging and access evaluations were scored positively, except for two aspects: (1) needle stability, and (2) ease of dressing. Ease of removal was scored unsatisfactory in up to 22.4% of the registrations. Pain at insertion was reported in about 20% registrations, and blood contact was reported by 2.5% of non-first-time users. Safety was scored as good, although ease of use and ease in training scored 25.4% and 43.8%, respectively, lower than the Gripper®. Conclusions In general, nurses evaluated the PPS positively, with the exception of needle stability, ease of dressing, and ease of removal. No needlestick accidents were recorded. Aspects of ease of use and ease of training for PPS needles scored less than those for the Gripper® needles in up to one-third of the registrations.
Criminal thinking patterns, aggression styles, and the psychopathic traits of late high school bullies and bully‐victims
Authors: Ragatz Laurie L. , Anderson Ryan J. , Fremouw William , Schwartz Rebecca 
Published: November 2010

AbstractThis study explored the current psychological characteristics and criminal behavior history of individuals who retrospectively reported being bullies, bully‐victims, victims, or controls (i.e. neither victims nor bullies) during their last 2 years of high school. College students (n = 960) completed measures of criminal thinking, aggression, psychopathy, and criminal behavior online. We predicted bullies and bully‐victims would demonstrate the highest scores for criminal thinking, proactive aggression, psychopathy, and have the most criminal infractions. Bullies and bully‐victims had significantly higher scores on criminal thinking, aggression, psychopathy, and criminal behaviors than victims or controls. Additionally, men were significantly higher in criminal thinking, aggression, psychopathy, and had more criminal acts than women. There were no gender by bully group interactions. Logistic regression analyses differentiated bully‐victims from bullies. Bully‐victims tended to be male, higher in criminal thinking, and higher in reactive aggression. In addition, bully‐victims were distinct from victims, showing higher criminal thinking and higher proactive aggression. Aggr. Behav. 37:145–160, 2011. © 2010 Wiley‐Liss, Inc.
N‐acetylcysteine prevents loss of dopaminergic neurons in the EAAC1−/− mouse
Authors: Berman Ari E. , Chan Wai Yee , Brennan Angela M. , Reyes Reno C. , Adler Brittany L. , Suh Sang Won , Kauppinen Tiina M. , Edling Ylva , Swanson Raymond A. 
Published: November 2010

AbstractObjectiveDopaminergic neuronal death in Parkinson's disease (PD) is accompanied by oxidative stress and preceded by glutathione depletion. The development of disease‐modifying therapies for PD has been hindered by a paucity of animal models that mimic these features and demonstrate an age‐related progression. The EAAC1−/− mouse may be useful in this regard, because EAAC1−/− mouse neurons have impaired neuronal cysteine uptake, resulting in reduced neuronal glutathione content and chronic oxidative stress. Here we aimed to (1) characterize the age‐related changes in nigral dopaminergic neurons in the EAAC1−/− mouse, and (2) use the EAAC1−/− mouse to evaluate N‐acetylcysteine, a membrane‐permeable cysteine pro‐drug, as a potential disease‐modifying intervention for PD.MethodsWild‐type mice, EAAC1−/− mice, and EAAC1−/− mice chronically treated with N‐acetylcysteine were evaluated at serial time points for evidence of oxidative stress, dopaminergic cell death, and motor abnormalities.ResultsEAAC1−/− mice showed age‐dependent loss of dopaminergic neurons in the substantia nigra pars compacta, with more than 40% of these neurons lost by age 12 months. This neuronal loss was accompanied by increased nitrotyrosine formation, nitrosylated α‐synuclein, and microglial activation. These changes were substantially reduced in mice that received N‐acetylcysteine.InterpretationThese findings suggest that the EAAC1−/− mouse may be a useful model of the chronic neuronal oxidative stress that occurs in PD. The salutary effects of N‐acetylcysteine in this mouse model provide an impetus for clinical evaluation of glutathione repletion in PD. ANN NEUROL 2010
Natural Helicobacter infection modulates mouse intestinal muscularis macrophage responses
Authors: Hoffman Sara M. , Fleming Sherry D. 
Published: November 2010

Abstract
Helicobacter species are common laboratory pathogens which induce intestinal inflammation and disease in susceptible mice. Since in vitro studies indicate that Helicobacter products activate macrophages, we hypothesized that in vivo Helicobacter infection regulates the inflammatory response of intestinal muscularis macrophages from C57Bl/6 mice. Helicobacter hepaticus infection increased surface expression of macrophage markers F4/80, CD11b and MHC‐II within whole intestinal muscle mounts. However, constitutive cytokine and chemokine production by macrophages isolated from infected mice significantly decreased compared to macrophages from uninfected mice despite no detectable bacterial products in the cultures. In addition, muscularis macrophages from infected mice up‐regulated FIZZ‐1 and SK‐1 gene expression, suggesting the macrophages had an anti‐inflammatory phenotype. Corresponding with increased anti‐inflammatory gene expression, macrophages from infected mice were more phagocytic but did not produce cytokines after stimulation with LPS and IFN‐γ or immune complexes and IL‐4. Therefore, the presence of Helicobacter infection matures intestinal muscularis macrophages, modulating the constitutive macrophage response to become more anti‐inflammatory and resistant to secondary stimulation. Copyright © 2010 John Wiley & Sons, Ltd.
Furano‐1,2‐naphthoquinone inhibits EGFR signaling associated with G2/M cell cycle arrest and apoptosis in A549 cells
Authors: Su J. C. , Lin K. L. , Chien C. M. , Tseng C. H. , Chen Y. L. , Chang L. S. , Lin S. R. 
Published: November 2010

AbstractFurano‐1,2‐naphthoquinone (FNQ), prepared from 2‐hydroxy‐1,4‐naphthoquinone and chloroacetaldehyde in an efficient one‐pot reaction, exhibits an anti‐carcinogenic effect. FNQ exerted anti‐proliferative activity with the G2/M cell cycle arrest and apoptosis in A549 cells. FNQ‐induced G2/M arrest was correlated with a marked decrease in the expression levels of cyclin A and cyclin B, and their activating partner cyclin‐dependent kinases (Cdk) 1 and 2 with concomitant induction of p53, p21, and p27. FNQ‐induced apoptosis was accompanied with Bax up‐regulation and the down‐regulation of Bcl‐2, X‐linked inhibitor of apoptosis (XIAP), and survivin, resulting in cytochrome c release and sequential activation of caspase‐9 and caspase‐3. Western blot analysis revealed that FNQ suppressed EGFR phosphorylation and JAK2, STAT3, and STAT5 activation, but increased in activation of p38 MAPK and c‐Jun NH2‐terminal kinase (JNK) stress signal. The combined treatment of FNQ with AG1478 (a specific EGFR inhibitor) significantly enhanced the G2/M arrest and apoptosis, and also led to up‐regulation in Bax, p53, p21, p27, release of mitochondrial cytochrome c, and down‐regulation of Bcl‐2, XIAP, survivin, cyclin A, cyclin B, Cdk1, and Cdk2 in A549 cells. These findings suggest that FNQ‐mediated cytotoxicity of A549 cell related with the G2/M cell cycle arrest and apoptosis via inactivation of EGFR‐mediated signaling pathway. Copyright © 2010 John Wiley & Sons, Ltd.
Application of AC‐SECM in Corrosion Science: Local Visualisation of Inhibitor Films on Active Metals for Corrosion Protection
Authors: Pähler Maike , Santana Juan José , Schuhmann Wolfgang , Souto Ricardo M. 
Published: November 2010

AbstractThe suitability of frequency‐dependent alternating‐current scanning electrochemical microscopy (4D AC‐SECM) for investigation of thin passivating layers covering the surface of corrosion‐inhibited metals has been demonstrated. Inhibition of copper corrosion by benzotriazole (BTAH) and methylbenzotriazole (MBTAH), which are effective inhibitors for this metal under many environmental conditions, was investigated. Strong dependencies were found for the AC z‐approach curves with both the duration of the inhibitor treatment and the frequency of the AC excitation signal applied in AC‐SECM. Both negative and positive feedback behaviours were observed in the AC approach curves for untreated copper and for Cu/BTAH and Cu/MBTAH samples. Negative feedback behaviour occurred in the low‐frequency range, whereas a positive feedback effect was observed at higher frequencies. A threshold frequency related to the passage from negative to positive regimes could be determined in each case. The threshold frequency for inhibitor‐modified samples was found always to be significantly higher than for the untreated metal, because the inhibitor film provides electrical insulation for the surface. Moreover, the threshold frequency increased with increasing surface coverage by the inhibitor. 4D AC‐SECM was successfully applied to visualizing spatially resolved differences in local electrochemical activity between inhibitor‐free and inhibitor‐covered areas of the sample.
Intramolecularly Coordinated Telluroxane Clusters and Polymers
Authors: Beckmann Jens , Bolsinger Jens , Duthie Andrew 
Published: November 2010

AbstractThe stoichiometrically controlled chlorination of the diarylditelluride (8‐Me2NC10H6Te)2 with SO2Cl2 afforded the aryltellurinyl chloride 8‐Me2NC10H6TeCl (1) and the aryltellurium trichloride 8‐Me2NC10H6TeCl3 (2). Alternatively, 1 was obtained by the reaction of the aryltellurenyl diethyldithiacarbamate 8‐Me2NC10H6Te(S2CNEt2) with hydrochloric acid. The base hydrolysis of 2 provided the novel telluroxanes (8‐Me2NC10H6Te)2OCl4 (3), (8‐Me2NC10H6Te)6O5Cl8 (4), (8‐Me2NC10H6Te)6O8Cl2 (5), [(8‐Me2NC10H6Te)2O3]n (6) and (8‐Me2NC10H6Te)6O8(OH)2 (7) depending on the reaction conditions applied. The reaction of 7 with ClTe(OiPr)3 in the presence of water gave rise to the telluroxane (8‐Me2NC10H6Te)6Te2O12Cl2 (8). The crystal and molecular structures of 1–3 and 5–8 were determined by X‐ray crystallography. The telluroxane clusters and polymers 6–8 hold potential as model compounds for alkali tellurite glasses (M2O)x(TeO2)1−x (M=Li, Na, K) for which no precise structural data are available.
One‐, Two‐ and Three‐Periodic Metal–Organic Rotaxane Frameworks (MORFs): Linking Cationic Transition‐Metal Nodes with an Anionic Rotaxane Ligand
Authors: Vukotic V. Nicholas , Loeb Stephen J. 
Published: November 2010

AbstractA new singly charged pyridinium axle was prepared and combined with disulfonated dibenzo[24]crown‐8 ether to form a [2]pseudorotaxane. The reaction of this new, anionic ligand with ZnII ions, under various crystallization conditions, resulted in the formation of three metal–organic rotaxane framework (MORF) solids; a one‐periodic ML coordination polymer and two, two‐periodic ML2 square grid frameworks. The layers of square grids can be pillared to create full three‐perioidic MORF structures, which have completely neutral frameworks and are porous. These three‐perioidic materials represent the first examples of neutral porous MOFs in which one (or more) of the linkers is a mechanically interlocked molecule (MIM).
Stream processing on GPUs using distributed multimedia middleware
Authors: Repplinger Michael , Slusallek Philipp 
Published: November 2010

AbstractAvailable GPUs provide increasingly more processing power especially for multimedia and digital signal processing. Despite the tremendous progress in hardware and thus processing power, there are and always will be applications that require using multiple GPUs either running inside the same machine or distributed in the network due to computationally intensive processing algorithms. Existing solutions for developing applications for GPUs still require a lot of hand‐optimization when using multiple GPUs inside the same machine and provide in general no or only limited support for using remote GPUs distributed in the network. In this paper we address this problem and show that an open distributed multimedia middleware, like the Network‐Integrated Multimedia Middleware (NMM), is able (1) to seamlessly integrate processing components using GPUs, while completely hiding GPU‐specific issues from the application developer, (2) to transparently combine processing components using GPUs or CPUs, and (3) to transparently use local and remote GPUs for distributed processing. Furthermore, we present a generic distribution framework to simplify the development of complex application scenarios. Copyright © 2010 John Wiley & Sons, Ltd.
Massively parallel systolic‐array architectures for 2d IIR polyphase space–time plane‐wave beam digital filters
Authors: Madanayake Arjuna , Gunaratne Thushara K. , Bruton Len T. 
Published: November 2010

SUMMARYA systolic architecture has recently been proposed for implementing two‐dimensional infinite impulse response (IIR) space–time beam plane‐wave filters at a throughput of one‐frame‐per‐clock–cycle for such applications as real‐time broadband smart antennas. A novel polyphase systolic architecture is proposed here that further increases the throughput of these IIR beam filters, by a factor of M, to M‐frames‐per‐clock‐cycle, where M is the number of polyphases. The proposed method combines the polyphase approach, along with pipelining and look‐ahead optimization methods, to achieve frame sample frequencies that are several times higher than the clock‐cycle limit of the very large‐scale integration (VLSI) technology, thereby potentially allowing multi‐GHz frame sample frequencies using current custom VLSI circuits. The implementation of a field programmable gate array‐based real‐time prototype is described, tested and verified for the two‐phase case (M= 2) at a technology‐limited clock frequency of 50 MHz which corresponds to a throughput of 100 million‐frames‐per‐clock–cycle. Copyright © 2010 John Wiley & Sons, Ltd.
Low‐noise, low‐sensitivity, active‐RC allpole filters using impedance tapering
Authors: Jurisic Drazen , Moschytz George S. , Mijat Neven 
Published: November 2010

SUMMARYIn this paper it is shown that active‐RC filters whose sensitivity to component tolerances can be minimized by impedance tapering, will also have low output thermal noise. It is shown that impedance tapering will also reduce output thermal noise in OTA‐C filters. Copyright © 2010 John Wiley & Sons, Ltd.
Cursed by crude: the corporatist resource curse and the baku–tbilisi–ceyhan pipeline
Authors: Sovacool Benjamin K. 
Published: November 2010

AbstractBased primarily on research interviews and field research, this article explores the impacts of the Baku–Tbilisi–Ceyhan (BTC) pipeline, which traverses Azerbaijan, Georgia and Turkey. The article first describes its research methods and links two separate strands of political economy literature to develop the notion of a corporatist resource curse. This concept suggests that when private and government actors partner to extract resources such as oil rapidly, the arrangement produces a system that consolidates wealth and ignores the interests of civil society and the public. The BTC pipeline illustrates the corporatist resource curse nicely, as its primary beneficiaries are a consortium of private companies and government elites, whereas various financial, humanitarian, environmental, social and legal impacts are felt throughout society at large. The article concludes by drawing out the implications of the BTC pipeline and the corporatist resource curse for public policy, energy development, infrastructure projects and corporate social responsibility. Copyright © 2010 John Wiley & Sons, Ltd and ERP Environment.
Semi‐explicit rate‐dependent modeling of damage‐avoidance steel connections using HF2V damping devices
Authors: Rodgers Geoffrey W. , Mander John B. , Chase J. Geoffrey 
Published: November 2010

AbstractA rate‐dependent modeling technique is developed for moment resisting steel connections that utilize non‐linear viscous dampers. First, a model of the Maxwell‐type is developed that considers the non‐linear viscous damper and connection flexibility for translational motion. This model is compared with experimental results at several input motion frequencies to validate the results. The model is then extended to represent an exterior steel beam‐to‐column connection using damage‐avoidance design and non‐linear viscous dampers. By including terms to represent structural member and connection flexibility, using appropriate geometric transformations the model can be formulated to give the overall lateral load‐drift structural performance. Validation analysis shows good agreement between experimental observations and the model predictions. Copyright © 2010 John Wiley & Sons, Ltd.