bluuebunny/crossref_metadata_2025_split huggingface dataset:
Japanese nurses’ confidence in their understanding of telenursing via e-learning: A mixed-methods study
Authors: Kamei Tomoko , Kawada Aki , Kakai Hisako , Yamamoto Yuko , Nakayama Yuki , Mitsunaga Haruhiko , Nishimura Naoki 
Published: June 2024

Objective Telenursing e-learning courses have been shown to enhance nurses’ skills and knowledge; however, the subjective learning experience is unclear. In this study, we identified meta-inferences to quantitatively and qualitatively understand this experience, as well as the types of knowledge gained through an e-learning course and how they are linked to each other, in order to enhance nurses’ confidence in their understanding of telenursing. Methods We employed a single-arm intervention with a mixed-methods convergent parallel design. We converged participants’ self-reported pre- and post-course confidence scores with their reflections on the learning experience, which were reported qualitatively as improved or unimproved. A total of 143 Japanese nurses with a mean of 20 years of nursing experience participated in this study. Results Among the participants, 72.7% demonstrated improved confidence in their understanding of telenursing after completing the e-learning course. The baseline confidence score was originally higher in the group that reported unimproved confidence (p < .001). Although there was no statistical difference in the usability and practicality scores between the two groups, the qualitative learning experience in these aspects differed in terms of the depth of knowledge of telenursing obtained. Conclusions Nurses’ quantitative confidence in their understanding of telenursing after course completion was incongruent with their qualitative perspectives of the learning experience. Nursing educators, healthcare policymakers, and other stakeholders should consider that learners’ overconfidence in their understanding of telenursing and comprehension of e-learning materials may result in their failure to develop key telenursing competencies, skills, and knowledge.
The Differences in Spillover Effects of International Monetary Policy on Southeast Asian Economies
Authors: Kim Thi Tran Oanh , Nguyen Anh Viet Hong 
Published: June 2024

The aim of this study is analyzing the spillovers of monetary policies from three nations including the US, Japan, and China to the Southeast Asian economies through macroeconomic linkages. By using BVAR model, the research results present distinct responses of economic growth, interest rate and inflation index in Southeast Asia to external shocks of interest rate according to specific characteristics. In particular, nations adopting pegged regime have stronger responses to the changing of the Fed rate and Japanese monetary policy while the opposite trend is found in volatility of Chinese interest rate. However, nations with higher trade openness might have more sensitive reaction to monetary policy of all three countries. On the other hand, the impact of international monetary policies on Southeast Asian countries is explained quite different between the group having higher capital openness and the other one. In general, the results are consistent with many previous studies as well as Mundell-Fleming’s impossibility triple theory. JEL Classification: E52, F42, N10, O11.
The application of surgeon-administered ultrasound-guided popliteal sciatic nerve block in foot and ankle injuries
Authors: Chow Chun Lok , Siu Yuk Chuen , Ma Chun Man , Lui Tun Hing 
Published: June 2024

Introduction Ultrasound-guided popliteal sciatic nerve block has been described as a safe and consistent form of regional anesthesia for foot and ankle surgery. Little studies have been performed to prove the effectiveness of surgeon self-administered regional anesthesia for foot and ankle injury requiring an operation. This study aimed to assess the applicability and safety in surgeon-administered ultrasound-guided popliteal sciatic nerve block in providing anesthesia for foot and ankle fracture. Material and Methods Patients with foot and ankle injury who underwent operation under surgeon-administered ultrasound-guided popliteal sciatic nerve block were evaluated in this retrospective study. A total of 7 patients (3 females and 4 males) with a mean age of 46) were evaluated by the diagnosis, side of injury, comorbidities in American Society of Anesthesiologists Classification (ASA), duration of operation, blood loss, pain control in visual analog scale (VAS) intra-operatively, degree of motor blockage, post-operative pain control and hospital length of stay. Result Average age of the study population was 46. Of all the patients, two of them were of ASA I four of them were of ASA II and one of them was of ASA III. Complete sensory and motor blockages were achieved for all patients. Average operative time was 117 min. Average blood loss was 16.4 mL. Average post-operative inpatient stay was 3.57 days. There was no regional anesthesia-related complication arising from the procedure. Conclusion Surgeon-administered popliteal sciatic nerve block is a safe procedure and can provide excellent pain control throughout the operation according to our experience. Foot and ankle fracture fixation can be performed by orthopedic surgeons under this technique.
Cultural Dynamics of Irregular Ethiopian Migration: Insights From Kembata Emigrants to the Republic of South Africa
Authors: Megersa Hailu , Tafesse Tesfaye 
Published: June 2024

Executive Summary This paper examines the cultural influences on irregular migration to South Africa from the Kembata-Tembaro Zone of Ethiopia. It reports on a mixed methods study, with a cross-sectional household survey ( n = 316) to examine indicators about society’s perceptions, cultural values, and the impact of remittances on migration. In-depth interviews ( n = 24) with migrant returnees and experts in the Kembata-Tembaro Zone Labor and Social Affairs Office explored their experiences and perceptions of irregular migration. The study established a connection between cultural influences and irregular migration of Ethiopians to the Republic of South Africa. Overall, the study demonstrates that the culture of migration among the Kembatas is primarily driven by a cumulative migration experience facilitated through migrant social networks. Economic incentives, such as prospects of better income and improved living conditions, are the main drivers for individuals to embark on this migratory journey. In addition, social factors, including familial networks, community ties, and remittances from migrants, significantly influence households’ attitudes toward migration. The paper ends with recommendations to address the problems related to irregular Ethiopian migration to South Africa, to enhance the well-being of Kembata emigrants, and to maximize the benefits of migration.
FDI spillovers on Colombian Multilatinas: Upgrading capabilities through indirect ties and humbleness
Authors: Pla-Barber José , Villar Cristina , Mesa Callejas Ramón Javier , Botella Andreu Ana 
Published: June 2024

This study examines how Colombian Multilatinas leverage spillovers from foreign direct investments to enhance their capabilities and expand internationally. Employing a qualitative, exploratory multi-case study approach grounded in inter-organizational learning theory, we find that indirect ties, through vicarious learning via observation and emulation, are pivotal in facilitating the acquisition of new knowledge. This learning is key for Multilatinas to improve their technological and organizational capabilities locally, thereby strengthening their position in global markets. In addition, our analysis reveals that the challenges inherent to the Colombian context encourage a distinctive internationalization model characterized by humility and collaborative partnerships. These findings offer actionable insights for managers aiming to leverage international spillovers for capability development and global growth. JEL CLASSIFICATION: M16; M21; M14
Self-efficacy of Menstrual Hygiene Management and Menstrual Absenteeism Among Students of a College in Kolkata
Authors: Datta Mousumi , Yasmin Shamima , Guchhait Debjani 
Published: June 2024

Background: Gender inequality, cultural taboos, poverty and lack of proper information can cause menstrual health needs to go unmet. It restricts mobility, personal choices, work participation and well-being. Nevertheless, self-efficacy in the menstrual hygiene management of college students has been relatively unexplored. Objectives: We aimed to assess the self-efficacy of menstrual hygiene management and its association with college absenteeism, demographic and academic profiles. The study also aimed to explore concerns and beliefs related to menstruation. Materials and Methods: A cross-sectional descriptive mixed-method study was conducted to assess the self-efficacy of the menstrual hygiene management (using a novel scale) of students from a general college in Kolkata, West Bengal, India. The study also explored concerns and beliefs related to menstruation among the study subjects. The sample size was calculated to be 96. For the qualitative part, 30 willing students were purposively chosen. Results: The mean age of participants was 19.38 years (SD ± 1.23). Predominantly they belonged to nuclear families (65.6%) with a median family income of ₹12,000. Absenteeism for menstrual reasons was 12 (12.5%). There were 50 (52.1%) participants who reported facing religious restrictions. Self-efficacy had a mean score of 29.90 (standard error of mean = 0.513) and a median score of 31. The presence of religious restrictions, any restrictions and type of family were significantly associated with college absenteeism by the chi-square test ( P < .05). The logistic regression model showed a significant association with religious restriction. Conclusion: The study revealed multiple concerns of college-going students regarding menstrual hygiene despite reported high self-efficacy for menstrual hygiene management.
The Effectiveness and Tolerability of Switching Patients from Sacubitril/Valsartan, ARNI to Perindopril in Heart Failure with Reduced Ejection Fraction: EFFICIENT Trial
Authors: Jariwala Pankaj , Gude Dilip , Reddy Peddi Sridhar , Jabbar Abdul , Jariwala Anusha 
Published: June 2024

Objectives Heart failure with reduced ejection fraction (HFrEF) is an advancing illness that can be managed with various drugs. In this study, we present data on the tolerance of perindopril in patients with HFrEF who were switched from angiotensin receptor neprilysin inhibitor (ARNI) to perindopril because of issues with the former’s tolerability or increased medication costs. Methods A total of 125 patients with HFrEF were switched to perindopril in this retrospective study carried out at the heart failure clinic. Of those, 109 patients had data accessible for a 6-month follow-up. The data of the patients who switched from ARNI to perindopril between June and December 2023 were collected. Data such as the New York Heart Association (NYHA) class, N-terminal pro hormone brain natriuretic peptide (NT-proBNP), and left ventricular ejection fraction (LVEF) were compared at baseline and 6-month follow- up with those collected after the switchover. Results During the transition, the average age was 58 ± 13 years (mean ± standard deviation), the disease duration was 2.6 ± 1.4 years, and 29.6% of the patients were female. The average period of follow-up following the transition was 5.7 ± 1.5 months. The 6-minute walk distance (6MWD) reduced from 344 ± 106 to 319 ± 85 m ( P = .056), but the NT-pro BNP levels increased from 478 ± 170 to 490 ± 137 pg/mL ( P = .56) after the transfer. All patients continued to maintain their NYHA functional class after the transition, with no significant difference seen ( P = .37). There was a little improvement in LVEF from 40% ± 4% to 41.5% ± 5% ( P < .001) during the follow-up after the switchover. Following the transition, no changes were observed in vital indicators, serum electrolytes, and creatinine levels. All patients successfully tolerated the transition to perindopril. Conclusions The transfer from ARNI to perindopril was both well tolerated and safe. The patients’ functional condition remained unchanged, as did their NT-pro BNP levels. A modest improvement in LVEF was noted. In India, switching from ARNI to perindopril is less expensive.
Community-Based Participatory Research for Epidemiology, Health Equity, and Community Goals: Insights From Brazil, France, and USA
Authors: Cohen Alison K. , Snyder Robert E. 
Published: June 2024

Background Community-based participatory research coproduces knowledge by emphasizing bidirectional exchanges between participants, communities, and researchers. Purpose, Research Design, and Study Sample We highlight three studies in historically marginalized communities on separate continents (Richmond, CA, USA; Rio de Janeiro, Brazil; Marseille industrial zone, France) to exemplify how community-based participatory research improves research, offers tangible community benefits, and values residents more than traditional research methods. Data Analysis We provide insights into the process of conducting meaningful community-based participatory epidemiologic research. Results In each of these communities, community-based participatory research led to high-quality research that helped inform context-appropriate policies and programs to improve health and advance health equity in these communities. Conclusions We recommend that researchers consistently engage with community members during all phases of research so that they can engage more participants, more deeply in the research process, build local capacity, improve data collection and data quality, as well as increase our understanding of research findings to inform future applied research and practice.
Analysis of polyfunctionality for enhanced BAFF-R CAR T-cell therapy for hematologic malignancies
Authors: Dong Zhengyuan , Budde L. Elizabeth , Oh Elizabeth , Szymura Szymon , Anderson Aaron , Del Real Marissa , Cha Soung-chul , Forman Stephen J. , Kwak Larry W. , Wang Xiuli 
Published: June 2024

Abstract
Chimeric antigen receptor (CAR) T-cell therapy has emerged as a promising immunotherapeutic strategy for eradicating human cancers. Their therapeutic success and durability of clinical responses hinges, in large part, on their functional capacity, including the ability of these engineered cells to simultaneously expand and persist after infusion into patients. CD19 CAR T-cell polyfunctionality, assessing the simultaneous functions of cytokine production, proliferation, and cytotoxicity has been reported to correlate with clinical outcomes. Assay optimization is potentially limited by the heterogeneous nature of CAR T-cell infusion products and target specificity. We optimized a single-cell platform for polyfunctionality using CAR T-cell products manufactured from healthy donors, engineered against a novel target, B-cell–activating factor receptor (BAFF-R) and validated the protocol using CD19 CAR T cells. We observed distinct qualitative differences between BAFF-R and CD19 CAR T cells relative to the proportions of stimulatory vs effector cytokines, based on target antigen density, and, generally, CD19 CAR T cells exhibited lower indices of polyfunctionality. Finally, we applied our assay to the autologous BAFF-R CAR T-cell product generated from the first patient with non-Hodgkin lymphoma treated in an ongoing clinical trial who had progressed after prior CD19 CAR T-cell therapy. We observed robust indicators of polyfunctionality, which correlated with successful CAR T-cell expansion after infusion and achievement of durable complete remission ongoing after 18 months. The precise identification of factors determining the role of BAFF-R CAR T-cell fitness in toxicity and clinical outcome will require the application of this robust assay in the analysis of additional treated patients. This trial was registered at www.ClinicalTrials.gov as #NCT05370430.
Biomedical applications of graphene-based nanomaterials: recent progress, challenges, and prospects in highly sensitive biosensors
Authors: Baruah Arabinda , Newar Rachita , Das Saikat , Kalita Nitul , Nath Masood , Ghosh Priya , Chinnam Sampath , Sarma Hemen , Narayan Mahesh 
Published: June 2024

AbstractGraphene-based nanomaterials (graphene, graphene oxide, reduced graphene oxide, graphene quantum dots, graphene-based nanocomposites, etc.) are emerging as an extremely important class of nanomaterials primarily because of their unique and advantageous physical, chemical, biological, and optoelectronic aspects. These features have resulted in uses across diverse areas of scientific research. Among all other applications, they are found to be particularly useful in designing highly sensitive biosensors. Numerous studies have established their efficacy in sensing pathogens and other biomolecules allowing for the rapid diagnosis of various diseases. Considering the growing importance and popularity of graphene-based materials for biosensing applications, this review aims to provide the readers with a summary of the recent progress in the concerned domain and highlights the challenges associated with the synthesis and application of these multifunctional materials.
Exploring the efficacy of subwavelength gratings as short-wavelength infrared filters
Authors: Liu Hezhuang , Huang Yixuan , Wu Jiang 
Published: June 2024

AbstractAdvancements in nanofabrication technology have greatly facilitated research on nanostructures and their associated properties. Among these structures, subwavelength components have emerged as promising candidates for ultra-compact optical elements, can potentially supplant conventional optical components and enable the realization of compact and efficient optical devices. Spectral analysis within the infrared spectrum offers a wealth of information for monitoring crop health, industrial processes, and target identification. However, conventional spectrometers are typically bulky and expensive, driving an increasing demand for cost-effective spectral sensors. Here we investigate three distinct subwavelength grating structures designed to function as narrowband filters within the short-wavelength infrared (SWIR) range. Through simple adjustments to the period of grating strips, these filters selectively transmit light across a wide wavelength range from 1100 to 1700 nm with transmission exceeding 70% and full width at half maximum (FWHM) down to 6 nm. Based on a simple design, the results present great potential of subwavelength grating filters for multiband integration and developing ultra-compact spectral sensors.
Different metazoan parasites, different transcriptomic responses, with new insights on parasitic castration by digenetic trematodes in the schistosome vector snail Biomphalaria glabrata
Authors: Lu Lijun , Bu Lijing , Laidemitt Martina R. , Zhang Si-Ming , Loker Eric S. 
Published: June 2024

Abstract
Background
Gastropods of the genus Biomphalaria (Family Planorbidae) are exploited as vectors by Schistosoma mansoni, the most common causative agent of human intestinal schistosomiasis. Using improved genomic resources, overviews of how Biomphalaria responds to S. mansoni and other metazoan parasites can provide unique insights into the reproductive, immune, and other systems of invertebrate hosts, and their responses to parasite challenges.

Results
Using Illumina-based RNA-Seq, we compared the responses of iM line B. glabrata at 2, 8, and 40 days post-infection (dpi) to single infections with S. mansoni, Echinostoma paraensei (both digenetic trematodes) or Daubaylia potomaca (a nematode parasite of planorbid snails). Responses were compared to unexposed time-matched control snails. We observed: (1) each parasite provoked a distinctive response with a predominance of down-regulated snail genes at all time points following exposure to either trematode, and of up-regulated genes at 8 and especially 40dpi following nematode exposure; (2) At 2 and 8dpi with either trematode, several snail genes associated with gametogenesis (particularly spermatogenesis) were down-regulated. Regarding the phenomenon of trematode-mediated parasitic castration in molluscs, we define for the first time a complement of host genes that are targeted, as early as 2dpi when trematode larvae are still small; (3) Differential gene expression of snails with trematode infection at 40dpi, when snails were shedding cercariae, was unexpectedly modest and revealed down-regulation of genes involved in the production of egg mass proteins and peptide processing; and (4) surprisingly, D. potomaca provoked up-regulation at 40dpi of many of the reproduction-related snail genes noted to be down-regulated at 2 and 8dpi following trematode infection. Happening at a time when B. glabrata began to succumb to D. potomaca, we hypothesize this response represents an unexpected form of fecundity compensation. We also document expression patterns for other Biomphalaria gene families, including fibrinogen domain-containing proteins (FReDs), C-type lectins, G-protein coupled receptors, biomphalysins, and protease and protease inhibitors.

Conclusions
Our study is relevant in identifying several genes involved in reproduction that are targeted by parasites in the vector snail B. glabrata and that might be amenable to manipulation to minimize their ability to serve as vectors of schistosomes.
Genomic investigation of Salmonella enterica Serovar Welikade from a pediatric diarrhea case first time in Shanghai, China
Authors: Shen Yinfang , Zhou Yibin , Gong Jingyu , Li Gang , Liu Yue , Xu Xuebin , Chen Mingliang 
Published: June 2024

Abstract
Background
Salmonella, an important foodborne pathogen, was estimated to be responsible for 95.1 million cases and 50,771 deaths worldwide. Sixteen serovars were responsible for approximately 80% of Salmonella infections in humans in China, and infections caused by a few uncommon serovars have been reported in recent years, though not with S. Welikade. This study reports the first clinical case caused by S. Welikade in China and places Chinese S. Welikade isolates in the context of global isolates via genomic analysis. For comparison, S. Welikade isolates were also screened in the Chinese Local Surveillance System for Salmonella (CLSSS). The minimum inhibitory concentrations (MICs) of 28 antimicrobial agents were determined using the broth microdilution method. The isolates were sequenced on an Illumina platform to identify antimicrobial resistance genes, virulence genes, and phylogenetic relationships.

Results
The S. Welikade isolate (Sal097) was isolated from a two-year-old boy with acute gastroenteritis in 2021. Along with the other two isolates found in CLSSS, the three Chinese isolates were susceptible to all the examined antimicrobial agents, and their sequence types (STs) were ST5123 (n = 2) and ST3774 (n = 1). Single nucleotide polymorphism (SNP)-based phylogenetic analysis revealed that global S. Welikade strains can be divided into four groups, and these three Chinese isolates were assigned to B (n = 2; Sal097 and XXB1016) and C (n = 1; XXB700). In Group B, the two Chinese ST5123 isolates were closely clustered with three UK ST5123 isolates. In Group C, the Chinese isolate was closely related to the other 12 ST3774 isolates. The number of virulence genes in the S. Welikade isolates ranged from 59 to 152. The galF gene was only present in Group A, the pipB2 gene was only absent from Group A, the avrA gene was only absent from Group B, and the allB, sseK1, sspH2, STM0287, and tlde1 were found only within Group C and D isolates. There were 15 loci unique to the Sal097 isolate.

Conclusion
This study is the first to characterize and investigate clinical S. Welikade isolates in China. Responsible for a pediatric case of gastroenteritis in 2021, the clinical isolate harbored no antimicrobial resistance and belonged to phylogenetic Group B of global S. Welikade genomes.