bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward Magnetic Resonance‐Guided Electroanatomical Voltage Mapping for Catheter Ablation of Scar‐Related Ventricular Tachycardia: A Comparison of Registration Methods
Authors: TAO QIAN , MILLES JULIEN , VAN HULS VAN TAXIS CARINE , LAMB HILDO J. , REIBER JOHAN H.C. , ZEPPENFELD KATJA , VAN DER GEEST ROB J. 
Published: September 2011

Toward MR‐Guided Electroanatomical Voltage Mapping for Catheter Ablation. Introduction: Integration of preprocedural delayed enhanced magnetic resonance imaging (DE‐MRI) with electroanatomical voltage mapping (EAVM) may provide additional high‐resolution substrate information for catheter ablation of scar‐related ventricular tachycardias (VT). Accurate and fast image integration of DE‐MRI with EAVM is desirable for MR‐guided ablation.
Methods and Results:
Twenty‐six VT patients with large transmural scar underwent catheter ablation and preprocedural DE‐MRI. With different registration models and EAVM input, 3 image integration methods were evaluated and compared to the commercial registration module CartoMerge. The performance was evaluated both in terms of distance measure that describes surface matching, and correlation measure that describes actual scar correspondence. Compared to CartoMerge, the method that uses the translation‐and‐rotation model and high‐density EAVM input resulted in a registration error of 4.32±0.69 mm as compared to 4.84 ± 1.07 (P <0.05); the method that uses the translation model and high‐density EAVM input resulted in a registration error of 4.60 ± 0.65 mm (P = NS); and the method that uses the translation model and a single anatomical landmark input resulted in a registration error of 6.58 ± 1.63 mm (P < 0.05). No significant difference in scar correlation was observed between all 3 methods and CartoMerge (P = NS).
Conclusions:
During VT ablation procedures, accurate integration of EAVM and DE‐MRI can be achieved using a translation registration model and a single anatomical landmark. This model allows for image integration in minimal mapping time and is likely to reduce fluoroscopy time and increase procedure efficacy. (J Cardiovasc Electrophysiol, Vol. 23, pp. 74‐80, January 2012)
Seasonal changes of the mineral contents in the rumen of wild Yeso sika deer (Cervus nippon yesoensis)
Authors: HAYASHIDA Maki , SOUMA Kousaku , HANAGATA Osamu , OKAMOTO Masayo , MASUKO Takayoshi 
Published: September 2011

ABSTRACTThe rumen contents were collected from 36 wild Yeso sika deer (Cervus nippon yesoensis) captured by deer culling or by hunting in the spring, summer, autumn and winter in Hokkaido, Japan. Botanical classification was conducted, and the contents of mineral (calcium (Ca), phosphorus (P), potassium (K), sodium (Na), iron (Fe), copper (Cu) and zinc (Zn)) were measured. The animals were captured around pastures or fallow field areas in the Kushiro area. The rumen contents consisted of grasses and Sasa sp. leaves regardless of the season. Leaves and bark were ingested in the spring, autumn and winter. The macro‐mineral contents in the rumen showed seasonal changes. In the summer, the Ca, K and P contents were high, and the Na content was low. There were no seasonal changes in the Fe content. The P, Na and Fe contents were higher than the animals' requirements. In a future survey, it is needed to determine the mineral contents of the food ingested by wild Yeso sika deer.
SNPpath: Characterizing cattle SNPs by enriched pathway terms
Authors: WANG Qishan , WANG Minghui , YANG Yumei , PAN Yuchun 
Published: September 2011

ABSTRACTHigh‐density single nucleotide polymorphism (SNP) microarrays have made large‐scale genome‐wide association studies (GWAS) and genomic selection (GS) feasible. Valuable insight into the genetic basis underlying complex polygenic traits will likely be gained by considering functionally related sets of genes simultaneously. SNPpath, a suite of computer‐generated imagery‐based web servers has been developed to automatically annotate and characterize cattle SNPs by enriched KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway terms. The SNPpath allows users to navigate and analysis large SNP sets and is the only web server currently providing pathway annotations of cattle SNPs in National Center for Biotechnology Information's dbSNP database and three commercial platforms. Hence, we describe SNPpath and provide details of the query options, as well as biological examples of use. The SNPpath may be favorable for the analysis of combining SNP association analysis with pathway‐driven gene set enrichment analysis and is freely available at http://klab.sjtu.edu.cn/SNPpath.
Efficacy of a New Fluoroquinolone, JNJ-Q2, in Murine Models of Staphylococcus aureus and Streptococcus pneumoniae Skin, Respiratory, and Systemic Infections
Authors: Fernandez Jeffrey , Hilliard Jamese J. , Morrow Brian J. , Melton John L. , Flamm Robert K. , Barron Alfred M. , Lynch A. Simon 
Published: September 2011

ABSTRACT

The
in vivo
efficacy of JNJ-Q2, a new broad-spectrum fluoroquinolone (FQ), was evaluated in a murine septicemia model with methicillin-susceptible
Staphylococcus aureus
(MSSA) and methicillin-resistant
S. aureus
(MRSA) and in a
Streptococcus pneumoniae
lower respiratory tract infection model. JNJ-Q2 and comparators were also evaluated in an acute murine skin infection model using a community-acquired MRSA strain and in an established skin infection (ESI) model using a hospital-acquired strain, for which the selection of resistant mutants was also determined. JNJ-Q2 demonstrated activity in the MSSA septicemia model that was comparable to that moxifloxacin (JNJ-Q2 50% effective dose [ED
50
], 0.2 mg/kg of body weight administered subcutaneously [s.c.] and 2 mg/kg administered orally [p.o.]) and activity in the MRSA septicemia model that was superior to that of vancomycin (JNJ-Q2 ED
50
, 1.6 mg/kg administered s.c.). In an
S. pneumoniae
lower respiratory tract infection model, JNJ-Q2 displayed activity (ED
50
, 1.9 mg/kg administered s.c. and 7.4 mg/kg administered p.o.) that was comparable to that of gemifloxacin and superior to that of moxifloxacin. In both MRSA skin infection models, treatment with JNJ-Q2 resulted in dose-dependent reductions in bacterial titers in the skin, with the response to JNJ-Q2 at each dose exceeding the responses of the comparators ciprofloxacin, moxifloxacin, linezolid, and vancomycin. Additionally, in the ESI model, JNJ-Q2 showed a low or nondetectable propensity for ciprofloxacin resistance selection, in contrast to the selection of ciprofloxacin-resistant mutants observed for both ciprofloxacin and moxifloxacin. JNJ-Q2 demonstrated activity that was comparable or superior to the activity of fluoroquinolone or antistaphylococcal comparators in several local and systemic skin infection models performed with both
S. aureus
and
S. pneumoniae
and is currently being evaluated in phase II human clinical trials.
Genome Sequences of Two Stress-Tolerant Campylobacter jejuni Poultry Strains, 305 and DFVF1099
Authors: Takamiya Monica , Ozen Asli , Rasmussen Morten , Alter Thomas , Gilbert Tom , Ussery Dave W. , Knøchel Susanne 
Published: September 2011

ABSTRACT

Campylobacter jejuni
is a food-borne pathogen with a high prevalence in poultry meat, which in fresh unfrozen condition is the major source of campylobacteriosis.
C. jejuni
strains DFVF1099 and 305 are considered tolerant to several environmental stresses (T. Birk et al., J. Food Prot. 73:258–265, 2010; S. L. On et al., Int. J. Med. Microbiol. 296:353–363, 2006). Here, we report the genome sequences of
C. jejuni
305 and DFVF1099, a turkey and a chicken isolate, respectively.
Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells
Authors: Ito Asagi , Shirakawa Hitoshi , Takumi Naofumi , Minegishi Yoshihiko , Ohashi Ai , Howlader Zakir H , Ohsaki Yusuke , Sato Toshiro , Goto Tomoko , Komai Michio 
Published: September 2011

Abstract

Background
Vitamin K is essential for the posttranslational modification of various Gla proteins. Although it is widespread in several organs, including the testis, the function of vitamin K in these organs is not well characterized. In this study, we investigated the function of vitamin K in the testis and analyzed its role in steroidogenesis.

Methods
Eight-week-old male Wistar rats were fed a diet supplemented with menaquinone-4 (MK-4, 75 mg/kg diet), one of the predominant K2 vitamins present in the testis, for 5 weeks. In vivo testosterone levels of the rats' plasma and testes were measured by enzyme-linked immunosorbent assay, and in vitro testosterone levels of testis-derived tumor cells (I-10 cells) maintained in Ham's F-10 medium with 10% fetal bovine serum were measured following treatment with MK-4 (0 to 100 μM) at several time points. Testosterone and cellular protein levels were analyzed with respect to their effects on steroidogenesis.

Results
Testosterone levels in the plasma and testes of MK-4-fed rats were significantly increased compared to those of control rats, with no obvious differences in plasma luteinizing hormone levels. Secreted testosterone levels from I-10 cells were elevated by MK-4, but not by vitamin K1, in a dose-dependent manner independent of cAMP treatment. Western blot analysis revealed that expression of CYP11A, the rate-limiting enzyme in steroidogenesis, and phosphorylation levels of protein kinase A (PKA) and the cAMP response element-binding protein were all stimulated by the presence of MK-4. Enhancement of testosterone production was inhibited by H89, a specific inhibitor of PKA, but not by warfarin, an inhibitor of γ-glutamylcarboxylation.

Conclusions
MK-4 stimulates testosterone production in rats and testis-derived tumor cells via activation of PKA. MK-4 may be involved in steroidogenesis in the testis, and its supplementation could reverse the downregulation of testosterone production in elders.
Hepatoid adenocarcinoma of the gallbladder
Authors: Ellouze Sameh , Slim Charfi , Ahmad Guirat , Naourez Gouiaa , Ali Amouri , Héla Mnif , Mariem Kossentini , Mohamed Ben Amar , Tahia Boudawara 
Published: September 2011

Abstract
Hepatoid adenocarcinoma is a rare variant of extrahepatic adenocarcinoma which behaves like hepatocellular carcinoma in morphology and functionality.
We present a rare case of hepatoid adenocarcinoma of the gallbladder which invades deeply the liver bed, in a 59-year-old woman. Histologically, most of the mass in the gallbladder was composed of cells with eosinophilic cytoplasm arranged in a trabecular pattern, which resembled hepatocellular carcinoma. The main differential diagnosis was hepatocellular carcinoma with invasion into the gallbladder. The gallbladder origin of the hepatoid adenocarcinoma was verified by the presence of foci of conventional adenocarcinoma, the recognition of high-grade dysplasia in the adjacent epithelium and the absence of cirrhosis.
Completion of Adjuvant Chemotherapy and Use of Health Services for Older Women With Epithelial Ovarian Cancer
Authors: Fairfield Kathleen M. , Murray Kimberly , Lucas F. Lee , Wierman Heidi R. , Earle Craig C. , Trimble Edward L. , Small Laurie , Warren Joan L. 
Published: September 2011

Purpose This analysis identifies factors associated with completion of adjuvant chemotherapy for patients with ovarian cancer and subsequent use of health services. Patients and Methods We used the Surveillance, Epidemiology, and End Results (SEER) –Medicare database to identify 4,617 women age 65 years or older with ovarian cancer diagnosed from 2001 to 2005. By using multivariable analyses with completion of chemotherapy as the outcome of interest, we describe factors associated with completion of treatment, including age, race, marital status, comorbidities, and sociodemographic factors. Use of health services was captured from Medicare claims. Results Among 4,617 patients with untreated ovarian cancer, 1,329 (28.8%) received no chemotherapy, 1,139 (24.7%) received a partial course of chemotherapy, and 2,149 (46.5%) completed chemotherapy. Women age 75 years or older were at greater risk of incomplete chemotherapy versus women age 65 to 74 years (odds ratio [OR], 1.64; 95% CI, 1.33 to 2.04). Having two or more comorbidities was also significantly associated with incomplete chemotherapy (OR, 1.83; 95% CI, 1.34 to 2.50). Among women who received either a partial or complete course of chemotherapy, we did not find an increase in use of health services (hospitalizations, emergency department visits, or physician visits) for the oldest women (age 80 years or older) compared with younger women. Conclusion There is considerable room for improvement in helping older patients with ovarian cancer initiate and complete chemotherapy. The oldest women who completed chemotherapy in this study did not use health services more than younger women did. Treatment teams for older patients with ovarian cancer should include expertise in geriatric assessment, should carefully identify medical and psychosocial barriers to completing treatment, and should support patients throughout treatment.
Who Needs Poetry? Baudelaire, Benjamin, and the Modernity of “Le Cygne”
Authors: Newmark Kevin 
Published: September 2011

This essay considers Baudelaire's “Le Cygne” in terms of the crucial place the poem should occupy in any theoretical reflection on literary and historical “modernity.” Despite the proliferation in recent years of references to Walter Benjamin in the reception of Baudelaire's poetry, there are still very few examples of the kind of interpretation that Benjamin's allegorical model of understanding would require in a sustained reading of a text like “Le Cygne.” The essay explores why Benjamin's thinking about allegory seems to be resisted by literary critics in their reading of Baudelaire's poetry. It suggests that Benjamin's conception of allegory cannot adequately be addressed without first registering the impact that the allegorical dimension of poetic language exerts upon fundamental philosophical concepts such as subjectivity, experience, and historicity itself. If Benjamin insists on associating allegory with modernity in Baudelaire's poetry, this is because history can be said to become modern only at the moment that the thinking subject's own experience sustains an irreversible alteration that might best be characterized as “allegorical,” for want of a better term. The resistance of literary critics to Benjamin's notion of allegory thus turns out to be a deeper philosophical resistance to the possibility that, after Benjamin's writings on Baudelaire, subjectivity, history, and poetry could never be understood in the same ways.
The essay begins by noting how Benjamin's thinking about history is conditioned by his response to the poverty of experience in modernity. For Benjamin, recourse to the poetic language of allegory becomes a historical necessity; without it the experience of poverty is in danger of remaining inaccessible for knowledge. However, the kind of knowability that this poetry can grant may itself resist coherent theoretical formulation. The essay turns to “Le Cygne” in the wake of Benjamin's own consideration of that poem in an attempt to determine more specifically the allegorical principle that alone could enable the poverty of modern experience to become legible, both poetically and historically, in the text.
Whole Cancer Genome Sequencing by Next-Generation Methods
Authors: Ross Jeffrey S. , Cronin Maureen 
Published: September 2011

Abstract
Traditional approaches to sequence analysis are widely used to guide therapy for patients with lung and colorectal cancer and for patients with melanoma, sarcomas (eg, gastrointestinal stromal tumor), and subtypes of leukemia and lymphoma. The next-generation sequencing (NGS) approach holds a number of potential advantages over traditional methods, including the ability to fully sequence large numbers of genes (hundreds to thousands) in a single test and simultaneously detect deletions, insertions, copy number alterations, translocations, and exome-wide base substitutions (including known “hot-spot mutations”) in all known cancer-related genes. Adoption of clinical NGS testing will place significant demands on laboratory infrastructure and will require extensive computational expertise and a deep knowledge of cancer medicine and biology to generate truly useful “clinically actionable” reports. It is anticipated that continuing advances in NGS technology will lower the overall cost, speed the turnaround time, increase the breadth of genome sequencing, detect epigenetic markers and other important genomic parameters, and become applicable to smaller and smaller specimens, including circulating tumor cells and circulating free DNA in plasma.
Protein‐Polymer Conjugates
Authors: Briand Victoria A. , Kumar Challa V. , Kasi Rajeswari M. 
Published: September 2011

AbstractThis chapter focuses on the design and applications of protein‐polymer conjugates. Protein‐polymer conjugates are synthesized by conjugating a polymer chain or many polymer chains onto a protein. The site of conjugation, protein, polymer, and stoichiometry are important criteria when designing a protein‐polymer conjugate. The important structural aspects and functions of proteins, such as hierarchical structure and activity, are discussed. The various methods of site‐specific conjugation, “grafting to”, “grafting from” and cofactor reconstitution, are included along the pros and cons of each method. Conjugates synthesized by random conjugation are also discussed. The specific reactions used for protein attachment are not included, as numerous synthetic reviews exist; however, a broad overview of the field is presented. Novel conjugate structures can be synthesized by attaching synthetic peptide sequences onto polymers. In addition to design considerations, the range of applications from drug delivery systems to biosensors are discussed. This chapter aims to aid in furthering the knowledge and growth of the synergistic combination of proteins and polymers.
Triangular Graphene Grain Growth on Cube‐Textured Cu Substrates
Authors: Liu Jianwei , Wu Judy , Edwards Christina M. , Berrie Cindy L. , Moore David , Chen Zhijun , Maroni Victor A. , Paranthaman M. Parans , Goyal Amit 
Published: September 2011

AbstractThe growth of graphene has been carried out on cube‐textured (100) oriented Cu (CTO‐Cu) foils using chemical vapor deposition (CVD). Well‐aligned triangular grains self‐assembled on CTO‐Cu during CVD heating in flowing hydrogen. The nucleation of triangular graphene grains has been confirmed. This demonstrates that the shape and possible alignment of the graphene grains can potentially be tuned by changing the properties of the substrate, which should ultimately lead to improved electrical properties of the graphene. This type of graphene nucleation and alignment is novel and has not been observed in previous studies on other copper foil samples.
Quantum critical behavior of heavy fermions: Quasiparticles in the Gaussian fluctuation regime
Authors: Wölfle P. , Abrahams E. 
Published: September 2011

AbstractLandau quasiparticle (qp) theory may be extended into the non‐Fermi liquid regime of metallic compounds near a quantum critical point (QCP), provided the width of the quasiparticle states is less than their energy. Sufficiently far from the QCP, when the critical fluctuations are non‐interacting, their influence on the qp properties may be calculated in a controlled way. A prominent example is the `marginal Fermi liquid,' characterized by a logarithmic variation of the specific heat coefficient and a linear variation of the resistivity with temperature. The latter is induced by the interaction of qps with three‐dimensional ferromagnetic (FM) or, in a disordered system, with quasi‐two‐dimensional antiferromagnetic (AFM) spin fluctuations. It is argued that both types of fluctuations are present in YbRh2Si2. It is suggested that the experimentally observed crossover line at T* marks the changeover from AFM to FM fluctuations with increasing magnetic field. The non‐Fermi liquid behavior found in the electron spin resonance data on YbRh2Si2 may be completely interpreted using critical quasiparticle theory.
Exact ground states for polyphenylene type of hexagon chains
Authors: Trencsényi R. , Gulácsi K. , Kovács E. , Gulácsi Z. 
Published: September 2011

AbstractA technique based on positive semidefinite operator properties has been used in deducing exact ground states for hexagon chains of polyphenylene type (hexagons interconnected by bonds build up the 1D periodic structure), placed in a constant external magnetic field B perpendicular to the surface containing the system. The used Hubbard type of model takes into account B by Peierls phase factors, and has the peculiar property to provide only flat bands in the bare band structure for elevated external field values independent on the parameters entering in the kinetic part of the Hamiltonian. The deduced ground states are non‐magnetic or ferromagnetic in character, localized in the thermodynamic limit, and besides the fact that B is able to switch the system between different phases, emphasize that the localization length and connectivity conditions can be tuned by external magnetic fields.
Electron‐electron interactions and the metal‐insulator transition in heavily doped silicon
Authors: v. Löhneysen H. 
Published: September 2011

AbstractThe metal‐insulator (MI) transition in Si:P can be tuned by varying the P concentration or – for barely insulating samples – by application of uniaxial stress S. On‐site Coulomb interactions lead to the formation of localized magnetic moments and the Kondo effect on the metallic side, and to a Hubbard splitting of the donor band on the insulating side. Continuous stress tuning allows the observation of finite‐temperature dynamic scaling of σ (T,S) and hence a reliable determination of the critical exponent μ of the extrapolated zero‐temperature conductivity σ (0) ∼ | S ‐ Sc |μ, i.e., μ = 1, and of the dynamical exponent z = 3. The issue of half‐filling vs. away from half‐filling of the donor band (i.e., uncompensated vs. compensated semiconductors) is discussed in detail.
On the nature of a*kak and the emergence of the Born rule
Authors: Assis A.V.D.B. 
Published: September 2011

AbstractThis paper is intended to show that a review in the concept of the game theoretical utility, the revised utility to be applied to the definition of the utility of a wave function representing an object subsystem relative to its observer subsystem, both within an isolated system, leads to the emergence of Max Born's rule as a profit under a von Neumann good measure game.