bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-reported uptake of recommendations after dissemination of medication incident alerts
Authors: Cheung Ka-Chun , Wensing Michel , Bouvy Marcel L , De Smet Peter A G M , van den Bemt Patricia M L A 
Published: July 2012

IntroductionIn the Netherlands, a Central Medication Incidents Registration (CMR) system is operational. To prevent recurrence of reported medication incidents the CMR sends medication incident alerts with recommendations. It is up to the healthcare workers whether or not to implement the recommendations in clinical practice, which may lead to variations in degrees of uptake of the recommendations.ObjectiveThe aim of this study was to explore the degree of self-reported uptake of the recommendations and to identify potential determinants associated with successful uptake.DesignThis is a cross-sectional study conducted within a convenience sample of 33 Dutch hospital pharmacies. The study was carried out from April 2009 to September 2010.MeasurementsThree alerts were selected for the study: administration of methotrexate in a dosage of once a day instead of once a week, administration of undiluted potassium-sodium-phosphate concentrate, and administration of glucose 50% instead of 5%. The primary outcome was the degree of self-reported uptake of the specific recommendations and the associations of the degree of uptake with several potential determinants.ResultsTwenty-one hospitals (63.6%) had adopted all recommendations about methotrexate. A quarter of the hospitals (24.2%) had adopted all recommendations related to potassium-sodium-phosphate concentrate. For the alert about glucose 50%, none of the hospitals had implemented all the recommendations. No statistically significant associations between potential determinants and the degree of uptake were found.ConclusionsThis study is the first to investigate the degree of uptake of the recommendations of three different CMR alerts. The alerts varied in the degrees of self-reported uptake of the recommendations, with the methotrexate alert having the highest degree of uptake. No significant associations with potential determinants were found.
Neighbourhoods matter too: the association between neighbourhood socioeconomic position, population density and breast, prostate and lung cancer incidence in Denmark between 2004 and 2008
Authors: Meijer Mathias , Bloomfield Kim , Engholm Gerda 
Published: July 2012

BackgroundPrevious studies have shown that cancer incidence is related to a number of individual factors, including socioeconomic status. The aim of this study was to refine the current knowledge about indicators associated with cancer incidence by evaluating the influence of neighbourhood characteristics on breast, prostate and lung cancer incidence in Denmark.MethodsAll women aged 30–83 years were followed for breast cancer between 2004 and 2008, men between 50 and 83 years were followed for prostate cancer and both sexes between ages 50 and 83 were followed for lung cancer. Registry data obtained from Statistics Denmark included age, sex, availability of breast cancer screening, marital status, education, disposable income and occupational socioeconomic status on the individual level and population density and neighbourhood socioeconomic status (the proportion of unemployed) on the parish level. Frailty modelling with individuals on the first level and parishes on the second level was conducted.ResultsA significantly lower HR of breast cancer was found in areas with low population density (HR=0.93; CI 0.88 to 0.99), while neighbourhood unemployment had no effect. Inhabitants of lower unemployment areas had a higher risk of prostate cancer (HR=1.14; CI 1.08 to 1.21) compared with those in higher unemployment areas, whereas population density had no effect. Risk of lung cancer was lower in areas with lowest population density (HR=0.80; CI 0.74 to 0.85) and lowest in areas with lowest unemployment (HR=0.88; CI 0.84 to 0.92).ConclusionsIn addition to individual-level factors, characteristics on the neighbourhood level also have an influence on breast, prostate and lung cancer incidence.
The psychosocial pathway to mental well-being at the local level: investigating the effects of perceived relative position in a deprived area context
Authors: Kearns Ade , Whitley Elise , Bond Lyndal , Egan Matt , Tannahill Carol 
Published: July 2012

BackgroundThe study investigated whether perceived relative position was associated with mental well-being for people living in deprived areas, as a contribution to debates about income inequality, relative deprivation and health.MethodsA survey of 4615 residents of deprived areas of Glasgow measured mental well-being using the WEMWBS scale. Perceived relative position was assessed locally and across wider society in relation to housing, neighbourhood and standard of living. Personal and dwelling characteristics were controlled for.ResultsMental well-being was found to be positively associated with: perceived relative quality (RR 4.1, 95% CI 2.4 to 6.8) and status (RR 7.1, 95% CI 4.5 to 11.1) of the home; perceived internal reputation of the neighbourhood (RR 4.9, 95% CI 2.9 to 8.2), though not external reputation; and perceived relative standard of living (RR 5.2, 95% CI 3.2 to 8.4). Furthermore, respondents who thought they lived in an area where some people had higher incomes than others also reported higher mental well-being (RR 4.5, 95% CI 2.2 to 9.1), controlling for the effects of their own income.ConclusionStudies of inequality and health could give more consideration to the importance of the residential domain of housing and neighbourhood to mental well-being outcomes, via the psychosocial pathway. The local spatial scale may be more important to issues of relative deprivation than previously thought, as people make local as well as broader comparisons. The ability to make upward comparisons of income within deprived areas may be beneficial to residents rather than detrimental, possibly as an indicator of area progress and ‘normality’.
Asian dust storm events are associated with an acute increase in stroke hospitalisation
Authors: Kang Jiunn-Horng , Liu Tsai-Ching , Keller Joseph , Lin Herng-Ching 
Published: July 2012

ObjectiveAsian dust storms (ADS) are long-ranged meteorological phenomena, which are suggested to be associated with several health problems. This study aimed to investigate the risk of stroke hospitalisation following ADS events by conducting a population-based study.Study design and settingThe authors identified 810 947 hospitalisations with an admission diagnosis of stroke during the time period between 2000 and 2009 in Taiwan. The ARIMA method (Auto-Regressive Integrated Moving Average) was used to examine the associations between ADS episodes and the daily number of stroke hospitalisations.ResultsThere were 46 separate ADS episodes which resulted in a total of 135 ADS days between 2000 and 2009. The Kruskal–Wallis test revealed that there was a significant difference in the mean number of daily stroke admissions among ADS days (239.6), post-ADS days (249.2) and non-ADS days (219.7) (p<0.001). After adjusting for the time-trend effect, ambient temperature, season, SO2and CO, the authors found post-ADS days 1 and 2 to have a significantly higher number of stroke admission than non-ADS days. Post-ADS days 1 and 2 had significantly higher numbers of ischaemic but not haemorrhagic stroke admissions.ConclusionThe authors conclude that ADS events are associated with an acute increase in stroke admission rates.
A minimal dark matter interpretation for the CRESST-II signal
Authors: Dick Rainer , Sage Frederick S. 
Published: July 2012

AbstractWe report on the possible interpretation of the two proposed dark matter mass values mχ=11.6 GeV and mχ=25.3 GeV from CRESST-II within the framework of the Higgs portal minimal dark matter model. We find that the higher mass value yields a suitable fit with a dark matter-Higgs coupling η/2=0.157 and a recoil cross section which is compatible with contemporary estimates of the effective Higgs–nucleon coupling. On the other hand, the lower mass solution would require a large strangeness component in the nucleon to explain the corresponding nucleon recoil cross section reported by CRESST-II.
SPECTRA OF BLACK HOLE IN DE SITTER SPACETIME WITH HIGHLY DAMPED QUASINORMAL MODES: HIGH OVERTONE CASE
Authors: LIU MOLIN , HU XUEHUI , LU JUNWANG , LU JIANBO 
Published: July 2012

Motivated by recent physical interpretation on quasinormal modes presented by Maggiore [Phys. Rev. Lett. 100, 141301 (2008)], the adiabatic quantity method given by Kunstatter [Phys. Rev. Lett. 90, 161301 (2003)] is used to calculate the spectrums of a non-extremal Schwarzschild de Sitter black hole in this paper, as well as electrically charged case. According to highly damped Konoplya and Zhidenko's numerical observational results for high overtone modes [JHEP 06, 037 (2004)], we found that the asymptotic non-flat spacetime structure leads to two interesting facts: (i) near inner event horizon, the area and entropy spectrums, which are given by Aen= 8 n1πℏ, Sen= 2πn1ℏ, are equally spaced accurately. (ii) However, near outer cosmological horizon the spectrums, which are in the form of [Formula: see text], are not markedly equidistant. Finally, we also discuss the electrically charged case and find that the black holes in de Sitter spacetime have similar quantization behavior no matter with or without charge.
PCA-1/ALKBH3 Contributes to Pancreatic Cancer by Supporting Apoptotic Resistance and Angiogenesis
Authors: Yamato Ichiro , Sho Masayuki , Shimada Keiji , Hotta Kiyohiko , Ueda Yuko , Yasuda Satoshi , Shigi Naoko , Konishi Noboru , Tsujikawa Kazutake , Nakajima Yoshiyuki 
Published: July 2012

AbstractThe PCA-1/ALKBH3 gene implicated in DNA repair is expressed in several human malignancies but its precise contributions to cancer remain mainly unknown. In this study, we have determined its functions and clinical importance in pancreatic cancer. PCA-1/ALKBH3 functions in proliferation, apoptosis and angiogenesis were evaluated in human pancreatic cancer cells in vitro and in vivo. Further, PCA-1/ALKBH3 expression in 116 patients with pancreatic cancer was evaluated by immunohistochemistry. siRNA-mediated silencing of PCA-1/ALKBH3 expression induced apoptosis and suppressed cell proliferation. Conversely, overexpression of PCA-1/ALKBH3 increased anchorage-independent growth and invasiveness. In addition, PCA-1/ALKBH3 silencing downregulated VEGF expression and inhibited angiogenesis in vivo. Furthermore, immunohistochemical analysis showed that PCA-1/ALKBH3 expression was abundant in pancreatic cancer tissues, where it correlated with advanced tumor status, pathological stage and VEGF intensity. Importantly, patients with low positivity of PCA-1/ALKBH3 expression had improved postoperative prognosis compared with those with high positivity. Our results establish PCA-1/ALKBH3 as important gene in pancreatic cancer with potential utility as a therapeutic target in this fatal disease. Cancer Res; 72(18); 4829–39. ©2012 AACR.
Activation of Robo1 Signaling of Breast Cancer Cells by Slit2 from Stromal Fibroblast Restrains Tumorigenesis via Blocking PI3K/Akt/β-Catenin Pathway
Authors: Chang Po-Hao , Hwang-Verslues Wendy W. , Chang Yi-Cheng , Chen Chun-Chin , Hsiao Michael , Jeng Yung-Ming , Chang King-Jen , Lee Eva Y.-H.P. , Shew Jin-Yuh , Lee Wen-Hwa 
Published: July 2012

Abstract
Tumor microenvironment plays a critical role in regulating tumor progression by secreting factors that mediate cancer cell growth. Stromal fibroblasts can promote tumor growth through paracrine factors; however, restraint of malignant carcinoma progression by the microenvironment also has been observed. The mechanisms that underlie this paradox remain unknown. Here, we report that the tumorigenic potential of breast cancer cells is determined by an interaction between the Robo1 receptor and its ligand Slit2, which is secreted by stromal fibroblasts. The presence of an active Slit2/Robo1 signal blocks the translocation of β-catenin into nucleus, leading to downregulation of c-myc and cyclin D1 via the phosphoinositide 3-kinase (PI3K)/Akt pathway. Clinically, high Robo1 expression in the breast cancer cells correlates with increased survival in patients with breast cancer, and low Slit2 expression in the stromal fibroblasts is associated with lymph node metastasis. Together, our findings explain how a specific tumor microenvironment can restrain a given type of cancer cell from progression and show that both stromal fibroblasts and tumor cell heterogeneity affect breast cancer outcomes. Cancer Res; 72(18); 4652–61. ©2012 AACR.
Changing the Tumor Microenvironment: New Strategies for Immunotherapy
Authors: Berraondo Pedro , Umansky Viktor , Melero Ignacio 
Published: July 2012

Abstract
Solid tumors are composed of malignant cells surrounded by a tumor-conditioned stroma that contains extracellular matrix and a variety of nonmalignant populations, including myeloid cells, lymphocytes, fibroblasts, and endothelial cells. These stromal elements form a local immunoregulatory network that must be overcome to achieve eradication of established tumors by immunotherapy. On March 21–22, 2012, a symposium was held in Pamplona, Spain, to share the recent advances regarding the molecules and cells that create and sustain this immune-hostile tumor microenvironment. Excellent targets for immunotherapeutic intervention were identified, and a number of therapeutic strategies under translation from mouse to human were presented. Cancer Res; 72(20); 5159–64. ©2012 AACR.
Characterization of a Large Panel of Patient-Derived Tumor Xenografts Representing the Clinical Heterogeneity of Human Colorectal Cancer
Authors: Julien Sylvia , Merino-Trigo Ana , Lacroix Ludovic , Pocard Marc , Goéré Diane , Mariani Pascale , Landron Sophie , Bigot Ludovic , Nemati Fariba , Dartigues Peggy , Weiswald Louis-Bastien , Lantuas Denis , Morgand Loïc , Pham Emmanuel , Gonin Patrick , Dangles-Marie Virginie , Job Bastien , Dessen Philippe , Bruno Alain , Pierré Alain , De Thé Hugues , Soliman Hany , Nunes Manoel , Lardier Guillaume , Calvet Loreley , Demers Brigitte , Prévost Grégoire , Vrignaud Patricia , Roman-Roman Sergio , Duchamp Olivier , Berthet Cyril 
Published: July 2012

Abstract
Purpose: Patient-derived xenograft models are considered to represent the heterogeneity of human cancers and advanced preclinical models. Our consortium joins efforts to extensively develop and characterize a new collection of patient-derived colorectal cancer (CRC) models.
Experimental Design: From the 85 unsupervised surgical colorectal samples collection, 54 tumors were successfully xenografted in immunodeficient mice and rats, representing 35 primary tumors, 5 peritoneal carcinoses and 14 metastases. Histologic and molecular characterization of patient tumors, first and late passages on mice includes the sequence of key genes involved in CRC (i.e., APC, KRAS, TP53), aCGH, and transcriptomic analysis.
Results: This comprehensive characterization shows that our collection recapitulates the clinical situation about the histopathology and molecular diversity of CRC. Moreover, patient tumors and corresponding models are clustering together allowing comparison studies between clinical and preclinical data. Hence, we conducted pharmacologic monotherapy studies with standard of care for CRC (5-fluorouracil, oxaliplatin, irinotecan, and cetuximab). Through this extensive in vivo analysis, we have shown the loss of human stroma cells after engraftment, observed a metastatic phenotype in some models, and finally compared the molecular profile with the drug sensitivity of each tumor model. Through an experimental cetuximab phase II trial, we confirmed the key role of KRAS mutation in cetuximab resistance.
Conclusions: This new collection could bring benefit to evaluate novel targeted therapeutic strategies and to better understand the basis for sensitivity or resistance of tumors from individual patients. Clin Cancer Res; 18(19); 5314–28. ©2012 AACR.
CpG Island Methylator Phenotype–Positive Tumors in the Absence ofMLH1Methylation Constitute a Distinct Subset of Duodenal Adenocarcinomas and Are Associated with Poor Prognosis
Authors: Fu Tao , Pappou Emmanouil P. , Guzzetta Angela A. , Jeschke Jana , Kwak Ruby , Dave Pujan , Hooker Craig M. , Morgan Richard , Baylin Stephen B. , Iacobuzio-Donahue Christine A. , Wolfgang Christopher L. , Ahuja Nita 
Published: July 2012

AbstractPurpose: Little information is available on genetic and epigenetic changes in duodenal adenocarcinomas. The purpose was to identify possible subsets of duodenal adenocarcinomas based on microsatellite instability (MSI), DNA methylation, mutations in the KRAS and BRAF genes, clinicopathologic features, and prognosis.Experimental Design: Demographics, tumor characteristics, and survival were available for 99 duodenal adenocarcinoma patients. Testing for KRAS and BRAF mutations, MSI, MLH1 methylation, and CpG island methylator phenotype (CIMP) status was conducted. A Cox proportional hazard model was built to predict survival.Results: CIMP+ was detected in 27 of 99 (27.3%) duodenal adenocarcinomas and was associated with MSI (P = 0.011) and MLH1 methylation (P &lt; 0.001), but not with KRAS mutations (P = 0.114), as compared with CIMP− tumors. No BRAF V600E mutation was detected. Among the CIMP+ tumors, 15 (55.6%) were CIMP+/MLH1-unmethylated (MLH1-U). Kaplan–Meier analysis showed that tumors classified by CIMP, CIMP/MLH1 methylation status, or CIMP/MSI status could predict overall survival (OS; P = 0.047, 0.002, and 0.002, respectively), whereas CIMP/MLH1 methylation status could also predict time-to-recurrence (TTR; P = 0.016). In multivariate analysis, CIMP/MLH1 methylation status showed a significant prognostic value in both OS (P &lt; 0.001) and TTR (P = 0.023). Patients with CIMP+/MLH1-U tumors had the worst OS and TTR.Conclusions: Our results showed existence of CIMP in duodenal adenocarcinomas. The combination of CIMP+/MLH1-U seems to be independently associated with poor prognosis in patients with duodenal adenocarcinomas. This study also suggests that BRAF mutations are not involved in duodenal tumorigenesis, MSI, or CIMP development. Clin Cancer Res; 18(17); 4743–52. ©2012 AACR.
The Persistent Cold-Air Pool Study
Authors: Lareau Neil P. , Crosman Erik , Whiteman C. David , Horel John D. , Hoch Sebastian W. , Brown William O. J. , Horst Thomas W. 
Published: July 2012

The Persistent Cold-Air Pool Study (PCAPS) was conducted in Utah's Salt Lake valley from 1 December 2010 to 7 February 2011. The field campaign's primary goal was to improve understanding of the physical processes governing the evolution of multiday cold-air pools (CAPs) that are common in mountain basins during the winter. Meteorological instrumentation deployed throughout the Salt Lake valley provided observations of the processes contributing to the formation, maintenance, and destruction of 10 persistent CAP episodes. The close proximity of PCAPS field sites to residences and the University of Utah campus allowed many undergraduate and graduate students to participate in the study.
Ongoing research, supported by the National Science Foundation, is using the PCAPS dataset to examine CAP evolution. Preliminary analyses reveal that variations in CAP thermodynamic structure are attributable to a multitude of physical processes affecting local static stability: for example, synoptic-scale processes impact changes in temperatures and cloudiness aloft while variations in boundary layer forcing modulate the lower levels of CAPs. During episodes of strong winds, complex interactions between the synoptic and mesoscale f lows, local thermodynamic structure, and terrain lead to both partial and complete removal of CAPs. In addition, the strength and duration of CAP events affect the local concentrations of pollutants such as PM2.5.
The Effects of Vitamin D Deficiency on Atrial Fibrillation
Authors: Demir Mehmet , Uyan Umut , Melek Mehmet 
Published: July 2012

Background: Vitamin D deficiency is associated with cardiovascular disease such as coronary artery disease, heart failure, and hypertension. Vitamin D deficiency activates the renin–angiotensin–aldosterone system, which affects the cardiovascular system. For this reason, it could be suggested that there is a relationship between vitamin D deficiency and atrial fibrillation (AF). In our study, we compared 25-hydroxyvitamin D (25-OHD) levels between nonvalvular AF, valvular AF, and control groups in sinus rhythm. Method: A total of 102 patients with nonvalvular chronic AF without any other cardiovascular disease (mean age 62.51 ± 5.88; group I) and 96 patients with AF, which is associated with mitral valve disease (mean age 61.51 ± 5; group II) were included in our study. Of all, 100 age-matched healthy people with sinus rhythm were accepted as control groups (mean age 61.35 ± 5.44). Routine biochemical parameters, 25-OHD and parathormone levels were performed. Results: Baseline characteristics of the study groups were comparable. Group I patients had a lower vitamin D level than group II and the control group (6.51 ± 4.89, 9.24 ± 7.39, and 11.18 ± 6.98 ng/mL, P < .001, respectively). In groups I and II, the patients’ left atrium diameter and systolic pulmonary artery pressure are higher than the control group. Conclusion: As a result, our study revealed a relationship between vitamin D deficiency and nonvalvular AF.
Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment
Authors: Zeng Zhihong , Shi Yue Xi , Tsao Twee , Qiu YiHua , Kornblau Steven M. , Baggerly Keith A. , Liu Wenbin , Jessen Katti , Liu Yi , Kantarjian Hagop , Rommel Christian , Fruman David A. , Andreeff Michael , Konopleva Marina 
Published: July 2012

Abstract
The interactions between the bone marrow (BM) microenvironment and acute myeloid leukemia (AML) is known to promote survival of AML cells. In this study, we used reverse phase-protein array (RPPA) technology to measure changes in multiple proteins induced by stroma in leukemic cells. We then investigated the potential of an mTOR kinase inhibitor, PP242, to disrupt leukemia/stroma interactions, and examined the effects of PP242 in vivo using a mouse model. Using RPPA, we confirmed that multiple survival signaling pathways, including the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR), were up-regulated in primary AML cells cocultured with stroma. PP242 effectively induced apoptosis in primary samples cultured with or without stroma. Mechanistically, PP242 attenuated the activities of mTORC1 and mTORC2, sequentially inhibited phosphorylated AKT, S6K, and 4EBP1, and concurrently suppressed chemokine receptor CXCR4 expression in primary leukemic cells and in stromal cells cultured alone or cocultured with leukemic cells. In the in vivo leukemia mouse model, PP242 inhibited mTOR signaling in leukemic cells and demonstrated a greater antileukemia effect than rapamycin. Our findings indicate that disrupting mTOR/AKT signaling with a selective mTOR kinase inhibitor can effectively target leukemic cells within the BM microenvironment.
Some properties of starlike harmonic mappings
Authors: Aydog̃an Melike , Yemisci Arzu , Polatog̃lu Yaşar 
Published: July 2012

Abstract
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