bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stroke in Swedish children II: long‐term outcome
Authors: Christerson S , Strömberg B 
Published: July 2010

AbstractAim:  To evaluate the long‐term outcome of childhood stroke in a population‐based cohort of Swedish children.Methods:  We followed up children with stroke over 7 years from 2000 to 2006 in a health care region covering one‐fifth of the Swedish population. Children aged between 28 days and 18 years, who had arterial ischaemic stroke, cerebral sinus venous stroke or nontraumatic haemorrhagic stroke, were included. The long‐term outcome study 1.6–8.6 years later included a clinical investigation, evaluation of school performance, everyday activities and participation and health‐related quality of life questionnaires (International Classification of Functioning, Disability and Health, Child Health Questionnaire and Short‐Form General Health Survey).Results:  Of 51 children, 4 (8%) had died and 85% of the long‐term survivors had some acquired impairment: 65% of the children had neurological impairment, and 59% had deficits affecting school activity and participation. The parents experienced the negative effect of the stroke on their child’s general health, daily life activities and participation and also on their own family life.Conclusion:  Childhood stroke results in serious long‐term functional deficits in 85% of survivors affecting their everyday life, the child’s performances and the life of the family as a whole.
Human metallothioneins 2 and 3 differentially affect amyloid‐beta binding by transthyretin
Authors: Martinho Ana , Gonçalves Isabel , Cardoso Isabel , Almeida Maria R. , Quintela Telma , Saraiva Maria J. , Santos Cecília R. A. 
Published: July 2010

Transthyretin (TTR), an amyloid‐beta (Aβ) scavenger protein, and metallothioneins 2 and 3 (MT2 and MT3), low molecular weight metal‐binding proteins, have recognized impacts in Aβ metabolism. Because TTR binds MT2, an ubiquitous isoform of the MTs, we investigated whether it also interacts with MT3, an isoform of the MTs predominantly expressed in the brain, and studied the role of MT2 and MT3 in human TTR–Aβ binding. The TTR–MT3 interaction was characterized by yeast two‐hybrid assays, saturation‐binding assays, co‐immunolocalization and co‐immunoprecipitation. The effect of MT2 and MT3 on TTR–Aβ binding was assessed by competition‐binding assays. The results obtained clearly demonstrate that TTR interacts with MT3 with a Kd of 373.7 ± 60.2 nm. Competition‐binding assays demonstrated that MT2 diminishes TTR–Aβ binding, whereas MT3 has the opposite effect. In addition to identifying a novel ligand for TTR that improves human TTR–Aβ binding, the present study highlights the need to clarify whether the effects of MT2 and MT3 in human TTR–Aβ binding observed in vitro have a relevant impact on Aβ deposition in animal models of Alzheimer’s disease.Structured digital abstract
MINT‐7905930: Amyloid beta (uniprotkb:P05067) physically interacts (MI:0915) with Ttr (uniprotkb:P02767) by saturation binding (MI:0440)
MINT‐7905857: MT3 (uniprotkb:P25713) binds (MI:0407) to TTR (uniprotkb:P02766) by saturation binding (MI:0440)
MINT‐7905838: TTR (uniprotkb:P02766) physically interacts (MI:0915) with MT3 (uniprotkb:P25713) by two hybrid (MI:0018)
MINT‐7905914: Ttr (uniprotkb:P02766) physically interacts (MI:0915) with Mt3 (uniprotkb:P25713) by anti tag coimmunoprecipitation (MI:0007)
MINT‐7905895: TTR (uniprotkb:P02767) and Mt3 (uniprotkb:P37361) colocalize (MI:0403) by fluorescence microscopy (MI:0416)
Sexual Satisfaction in Females with Premenstrual Symptoms
Authors: Nowosielski Krzysztof , Drosdzol Agnieszka , Skrzypulec Violetta , Plinta Ryszard 
Published: July 2010

ABSTRACT

Introduction
The impact of premenstrual symptoms, such as the premenstrual syndrome (PMS) and the premenstrual dysphoric disorder (PMDD), on sexual satisfaction, sexual distress, and sexual behaviors has not yet been established.

Aims
To assess the correlates and risk factors of sexual satisfaction and to evaluate sexual behaviors among Polish women with premenstrual symptoms.

Methods
2,500 females, aged 18 to 45 years, from the Upper Silesian region of Poland were eligible for the questionnaire-based, prospective population study. All the inclusion criteria were met by 1,540 women who constituted the final study group. The participants were further divided into two subgroups: PMS+ (749 females) and PMS− (791 healthy subjects). Two additional subgroups were created: PMDD+ encompassing 32 subjects diagnosed with PMDD, and PMDD− comprising 32 healthy women, matched to the PMDD+ females for age, marital status, education level, employment status, place of living, and body mass index. A multiple logistic regression analysis was performed to evaluate the influence of PMS on sexual satisfaction and adjust for potential confounders.

Main Outcome Measure
To evaluate risk factors for sexual dissatisfaction in a population of Polish females of reproductive age, diagnosed with PMS and PMDD.

Results
Women from the PMS+ group were less sexually satisfied than PMS− (77.73% vs. 88.66%, P = 0.001) and reported more sexual distress (28.65% vs. 15.24%, P = 0.001). There were no significant differences in sexual satisfaction between PMDD− and PMDD+. Sexual satisfaction correlated positively with a higher frequency of sexual intercourses and a higher level of education. The presence of PMS correlated negatively with sexual satisfaction, even after adjusting for potential confounders in the multivariate logistic regression model (odds ratio=0.48; confidence interval: 0.26–0.89; P = 0.02).

Conclusions
The presence of PMS is a risk factor for sexual dissatisfaction in Polish women of reproductive age.
Strangulation of Penis by a Ball Bearing Device
Authors: Singh Iqbal , Joshi Mohit K. , Jaura Maninder S. 
Published: July 2010

ABSTRACT

Introduction
Penile strangulation is rare and usually results following placement of constricting objects to enhance sexual stimulation. It requires urgent treatment as delay may lead to irreversible penile ischemia and gangrene. Various objects causing penile strangulation have been reported. Nonmetallic and thin metallic objects can be removed easily as compared to heavy metallic objects. Cutting is the commonest method described, although procuring special cutting tools may be difficult and the process of cutting may be tedious with the possibility of iatrogenic penile injury.

Aim
To present a simple, safe, minimally invasive, effective, and feasible technique for removing heavy metallic objects constricting the penis.

Methods
The published English literature (PubMed™) was searched for cases of “penile strangulation” using the keywords penile strangulation, penile injury, penile trauma, penile constriction, penile entrapment, and penile incarceration. The described treatment modalities were carefully reviewed and studied.

Main Outcome Measures
Reviewed published English literature on the various causes of penile incarceration and the various techniques used for their extrication.

Results
Search results yielded several cases of penile strangulation caused by a variety of metallic and nonmetallic objects. Various modalities have been described in the English literature for their safe removal, each with its own merits and demerits.

Conclusions
Penile strangulation should be viewed and managed as an emergency in order to prevent penile necrosis and urethral injury and to preserve erectile function. The modified method described herein for managing penile strangulation due to heavy metallic rings is minimally invasive, safe, effective, does not require any special cutting instrument(s) or skill, and is free of causing iatrogenic collateral thermal or mechanical damage to the penile organ. A stepwise algorithm depicting a rational and comprehensive approach to the diagnosis and management of penile incarceration is also suggested for the clinicians.
Pubic Hair Removal among Women in the United States: Prevalence, Methods, and Characteristics
Authors: Herbenick Debra , Schick Vanessa , Reece Michael , Sanders Stephanie , Fortenberry J. Dennis 
Published: July 2010

ABSTRACT

Introduction
Although women’s total removal of their pubic hair has been described as a “new norm,” little is known about the pubic hair removal patterns of sexually active women in the United States.

Aims
The purpose of this study was to assess pubic hair removal behavior among women in the United States and to examine the extent to which pubic hair removal methods are related to demographic, relational, and sexual characteristics, including female sexual function.

Methods
A total of 2,451 women ages 18 to 68 years completed a cross-sectional Internet-based survey.

Main Outcome Measures
Demographic items (e.g., age, education, sexual relationship status, sexual orientation), cunnilingus in the past 4 weeks, having looked closely at or examined their genitals in the past 4 weeks, extent and method of pubic hair removal over the past 4 weeks, the Female Genital Self-Image Scale (FGSIS) and the Female Sexual Function Index (FSFI).

Results
Women reported a diverse range of pubic hair-grooming practices. Women’s total removal of their pubic hair was associated with younger age, sexual orientation, sexual relationship status, having received cunnilingus in the past 4 weeks, and higher scores on the FGSIS and FSFI (with the exception of the orgasm subscale).

Conclusion
Findings suggest that pubic hair styles are diverse and that it is more common than not for women to have at least some pubic hair on their genitals. In addition, total pubic hair removal was associated with younger age, being partnered (rather than single or married), having looked closely at one’s own genitals in the previous month, cunnilingus in the past month, and more positive genital self-image and sexual function.
DEVELOPMENT OF FIBER‐ENRICHED BISCUITS FORMULA BY A MIXTURE DESIGN
Authors: ELLOUZE‐GHORBEL RAOUDHA , KAMOUN AMEL , NEIFAR MOHAMED , BELGUITH SAMEH , AYADI MOHAMED ALI , KAMOUN AMAR , ELLOUZE‐CHAABOUNI SEMIA 
Published: July 2010

ABSTRACT The present research studies the optimization of the textural properties of new fiber‐enriched biscuit formulae. A mixture design was carried out in order to model the textural properties of dough and biscuit supplemented with Aestivum wheat bran (AWB) and durum wheat bran (DWB). The desirability function was used to determine the coordinates of fiber‐enriched biscuit formulae characterized presenting textural properties of dough (hardness, cohesiveness and adhesiveness) and biscuit (maximum peak force) close to those of the commercial product without fiber. Two optimal biscuit formulae (Optimal formula 1 (OM1): 86.66% of wheat flour, 6.67% of DWB and 6.67% of AWB and Optimal formula 2 (OM2): 73.30% of wheat flour, 13.35% of DWB and 13.35% of AWB) were tested at the industrial scale and provided highly acceptable scores from the taste panelists. PRACTICAL APPLICATIONSConsumption of dietary fiber provides health benefits including protection against cardiovascular diseases, cancer and other degenerative diseases. Wheat bran is a readily available and inexpensive source of dietary fiber. In this work, we developed new biscuit formulae enriched with both Aestivum and durum wheat brans. The substitution of wheat flour by wheat brans at their optimum levels led to dietary fiber‐enriched biscuits with improved functional and nutritional properties and without undesirable changes in their sensory properties.
Chromogranins A and B and secretogranin II: evolutionary and functional aspects
Authors: Montero‐Hadjadje M. , Vaingankar S. , Elias S. , Tostivint H. , Mahata S. K. , Anouar Y. 
Published: July 2010

AbstractChromogranins/secretogranins or granins are a class of acidic, secretory proteins that occur in endocrine, neuroendocrine, and neuronal cells. Granins are the precursors of several bioactive peptides and may be involved in secretory granule formation and neurotransmitter/hormone release. Characterization and analysis of chromogranin A (CgA), chromogranin B (CgB), and secretogranin II (SgII) in distant vertebrate species confirmed that CgA and CgB belong to related monophyletic groups, probably evolving from a common ancestral precursor, while SgII sequences constitute a distinct monophyletic group. In particular, selective sequences within these proteins, bounded by potential processing sites, have been remarkably conserved during evolution. Peptides named vasostatin, secretolytin and secretoneurin, which occur in these regions, have been shown to exert various biological activities. These conserved domains may also be involved in the formation of secretory granules in different vertebrates. Other peptides such as catestatin and pancreastatin may have appeared late during evolution. The function of granins as propeptide precursors and granulogenic factors is discussed in the light of recent data obtained in various model species and using knockout mice strains.
Duodenal epithelial sensing of luminal acid: role of carbonic anhydrases
Authors: Sjöblom M. 
Published: July 2010

AbstractSensing the luminal contents is a prerequisite to activate appropriate gastrointestinal functions. A major task of the duodenal epithelium is to resist the repeated challenges of hydrochloric acid expelled from the stomach. Although extensive research in this field, the complete mechanisms providing this defence remain to be revealed. The duodenal epithelium exports bicarbonate into a submillimetre‐thick mucus gel on top of the mucosal surface. Despite the very low pH of the luminal contents, the duodenal mucus–bicarbonate barrier provides a means of maintaining a virtually neutral pH at the epithelial surface. Instead of pH, CO2 generated by the mixing of acid and bicarbonate at levels not found elsewhere in the body serves as the mediator for sensing the luminal acid. Carbonic anhydrases (CAs) catalyse the reversible hydration of CO2 and are heavily expressed in the duodenal segment. Accumulating data support the key function of CAs in sensing luminal acid and CO2. Recent advances demonstrate that the presence of CA II in upper villus plays a crucial role in enterocyte intracellular acidification preceding the secretory increase in response to luminal acid. However, CAs only have a minor role in the bicarbonate supply destined for duodenal bicarbonate secretion into the lumen. The purpose of this review is to summarize the current knowledge of how intraluminal acid is sensed by the duodenal mucosa, with a focus on the role of CAs.
Novel Rare Earth–Polyvinyl Pyridine Complex Functionalized Hybrid Silica Microspheres: Molecular Assembly and Photophysical Property
Authors: Guo Lei , Yan Bing 
Published: July 2010

AbstractThe functional silica microspheres are derived from the three different silane crosslinking reagents, and then the polyvinyl pyridine‐based rare earth hybrids are synthesized through free radical copolymerization of rare earth–vinyl pyridine complex monomer with these functionalized silica microspheres (RE = Eu, Tb). The obtained hybrids are characterized by Fourier transform infrared, X‐ray diffraction, Scanning electronic microscope and photoluminescence spectra. The intramolecular energy transfer process between rare earth ions and polymer polyvinyl pyrrolidone matrices took place within these polymer‐based hybrids and especially the quantum efficiency of europium hybrids are determined, suggesting that the hybrid material systems derived from different functional silica microspheres present different luminescence efficiencies.
Safety and Tolerability of the Direct Renin Inhibitor Aliskiren: A Pooled Analysis of Clinical Experience in More Than 12,000 Patients With Hypertension
Authors: White William B. , Bresalier Robert , Kaplan Allen P. , Palmer Biff F. , Riddell Robert H. , Lesogor Anastasia , Chang William , Keefe Deborah L. 
Published: July 2010

J Clin Hypertens (Greenwich). 2010;12:765‐775. © 2010 Wiley Periodicals, Inc.While the safety of renin‐angiotensin system (RAS)–blocking drugs such as angiotensin‐converting enzyme (ACE) inhibitors and angiotensin receptor blockers is well known, less is known about the new direct renin inhibitor aliskiren. The authors pooled data from 12 randomized controlled trials of aliskiren in patients with hypertension and analyzed the incidence and types of adverse events (AEs) and laboratory abnormalities. Studies were characterized as short‐term (≤2 months) placebo‐controlled or long‐term (>2 months) active‐controlled. Relative risks for AEs of particular interest for RAS blockers were calculated. In short‐term studies, AEs occurred in similar proportions of aliskiren 150 mg and 300 mg (33.6% and 31.6%, respectively) and placebo treatment groups (36.8%). In long‐term studies, a lower proportion of patients treated with aliskiren 150 mg and 300 mg had AEs (33.7% and 43.2%, respectively) than those treated with ACE inhibitors (60.1%), angiotensin receptor blockers (53.9%), and thiazide diuretics (48.9%). Events of special interest, including angioedema, hyperkalemia, and diarrhea occurred in similar proportions of patients taking aliskiren, placebo, and comparator agents. In studies of up to 36 weeks, patients treated with aliskiren were significantly less likely to develop cough than those treated with ACE inhibitors. At the registered doses of 150 mg and 300 mg daily, aliskiren has safety and tolerability profiles similar to placebo, other RAS blockers, and diuretics. Cough rates are lower with aliskiren compared with ACE inhibitors.
A QUESTION OF ABSENCE
Authors: Gerrard Jackie 
Published: July 2010

abstractThis paper was written in an effort to process rather extreme countertransference reactions to an ‘absent’ patient, i.e. one who attended her twice‐weekly psychotherapy only sporadically. At times she did not come for up to several months and consequently a serious debt would accrue. However, it was not so much the amount owing but rather the constant cancellations, with seemingly ‘rational’ excuses about her non‐attendance that would provoke an intense frustration accompanied, at times, by furious, almost sadistic countertransference feelings. The patient kept her therapist ‘dangling in uncertainty’ (Brenman Pick, 2002), which the author considered to be a reflection of the patient's inner sado‐masochistic object world. The author attempts to make sense of her countertransference in the light of the patient's early relationships and subsequently forms a hypothesis that the absences have been necessary to convey, very powerfully, experiences that may not have been communicated by regular attendance. Finally, the author offers her ‘Afterthoughts’ in the light of developments since the patient has read the paper and given her permission for publication.
THE O OF EMPTINESS AND THE EMPTINESS OF O
Authors: Mendoza Steven 
Published: July 2010

abstractIn this paper I try to show how Bion's sense of ‘O’ may usefully be seen as similar to the Buddhist notion of emptiness. I try to instantiate some of his ideas and I hope that by doing so I might contribute to the realization in the consulting room of his injunctions. I try to explore a possible difference in interpretation between the terms identity and identification and to use the distinction to suggest how emptiness can clarify the real nature of the ego as Freud accounted of it and how its realization can instantiate ego strength.
Empirical geographic modeling of switchgrass yields in the United States
Authors: JAGER HENRIETTE I. , BASKARAN LATHA M. , BRANDT CRAIG C. , DAVIS ETHAN B. , GUNDERSON CARLA A. , WULLSCHLEGER STAN D. 
Published: July 2010

AbstractSwitchgrass (Panicum virgatum L.) is a perennial grass native to the United States that has been studied as a sustainable source of biomass fuel. Although many field‐scale studies have examined the potential of this grass as a bioenergy crop, these studies have not been integrated. In this study, we present an empirical model for switchgrass yield and use this model to predict yield for the conterminous United States. We added environmental covariates to assembled yield data from field trials based on geographic location. We developed empirical models based on these data. The resulting empirical models, which account for spatial autocorrelation in the field data, provide the ability to estimate yield from factors associated with climate, soils, and management for both lowland and upland varieties of switchgrass. Yields of both ecotypes showed quadratic responses to temperature, increased with precipitation and minimum winter temperature, and decreased with stand age. Only the upland ecotype showed a positive response to our index of soil wetness and only the lowland ecotype showed a positive response to fertilizer. We view this empirical modeling effort, not as an alternative to mechanistic plant‐growth modeling, but rather as a first step in the process of functional validation that will compare patterns produced by the models with those found in data. For the upland variety, the correlation between measured yields and yields predicted by empirical models was 0.62 for the training subset and 0.58 for the test subset. For the lowland variety, the correlation was 0.46 for the training subset and 0.19 for the test subset. Because considerable variation in yield remains unexplained, it will be important in the future to characterize spatial and local sources of uncertainty associated with empirical yield estimates.
Mycobacteria are hidden endophytes in the shoots of rock plant [Pogonatherum paniceum (Lam.) Hack.] (Poaceae)
Authors: Koskimäki Janne J. , Hankala Elina , Suorsa Marja , Nylund Sannakajsa , Pirttilä Anna Maria 
Published: July 2010

SummaryA mycobacterium was isolated from micropropagated Pogonatherum paniceum and identified as a close relative of Mycobacterium cookii. The endophyte diversity in the shoots of potted and micropropagated P. paniceum plants was studied by culture‐independent techniques. Group‐ and strain‐specific PCR demonstrated that the P. paniceum plants harboured the isolated Mycobacterium strain as a minority. Altogether 101 clones of the PCR products were sequenced. The shoots of potted P. paniceum plants harboured unculturable endophytes in the families Phyllobacteriaceae, Hyphomicrobiaceae, Sphingobacteriaceae, Enterobacteriaceae, Alcaligenaceae and Mycobacteriaceae. Among the unculturable Mycobacteriaceae strains related to Mycobacterium chubuense, M. poriferae, M. obuense, M. fortuitum, M. neoaurum, M. diernhoferi, M. intracellulare and M. cookii were identified. Three unique sequences that clustered with M. llatzarense and M. mucogenicum were identified in micropropagated plants. According to the results, the shoots and micropropagated tissues of rock plant are inhabited by mycobacteria, which should stimulate further studies on the diversity of unculturable mycobacteria in edible crop plants.