bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flushing in children with cutaneous mastocytosis
Authors: Kasikhina E. I. , Zhukova O. V. , Ostretsova M. N. , Kochetkov M. A. , Nada A. Ya. 
Published: May 2024

Introduction. Flushing is a subjective feeling of warmth that is accompanied by redness of the skin on any part of the body, but mainly on the face, neck and upper trunk. Episodic flushing with other symptoms associated with mast cell mediators can be observed in 30–50% of children with cutaneous mastocytosis (CM).Aim. To analyze the frequency of flushing in children with various clinical forms of cutaneous mastocytosis. To study serum tryptase levels in children with flushing.Materials and methods. The study included data from 275 children aged from 6 months to 17 years inclusive, who were undergoing outpatient treatment and observation at the Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology from March 2022 until January 2024. The concentration of tryptase in the blood was determined by immunofluo-rescence on a three-dimensional porous solid phase (ImmunoCAP technology, Pharmacia Diagnostics AB, Sweden). Polarization and immersion dermatoscopy with 20x magnification were performed.Results. Flushings were observed in 17.5% of patients out of 275 observed children with CM. The level of tryptase more than 15 µg/l was determined in 20.8% of children with flushing, above 11.0 µg/l – in 37.5%. Tryptase levels were higher than 8.0 µg/L in 22 (45.8%) patients. In 25.0% of patients with flushing, tryptase levels did not exceed 5 µg/L. The severity of the vascular pattern in lesions and apparently healthy skin was characteristic of patients with frequent or prolonged flushing and tryptase levels above 8.0 µg/L.Conclusion. This study was the first in the Russian Federation to demonstrate the prevalence of flushing in children with various clinical forms of cutaneous mastocytosis. The results showed that the assessment of serum tryptase levels should be performed in all children with flushing, regardless of the clinical form of mastocytosis, including those with isolated and multiple skin mastocytomas. Clinical laboratory and dermatoscopic monitoring are important for the development of individual therapeutic tactics and prevention of mediator reactions and anaphylaxis.
Hereditary human diseases with skeletal pathology – molecular pathogenesis and clinical characteristics
Authors: Valeeva D. I. , Khusainova R. I. , Khusainova L. N. , Tyurin A. V. 
Published: May 2024

Differential diagnosis of hereditary diseases is challenging due to similar clinical manifestations, diversity of nosologies, wide clinical variability and genetic heterogeneity, severity, rare frequency and complex molecular etiology. In some of them, connective tissue as a whole is involved in the pathological process, affecting almost all organs and systems of the human body, and in particular bone tissue, disrupting its remodeling and microarchitecture. The defect can occur at any of the stages of remodeling: during the initiation process, during bone resorption, osteoblast differentiation, osteoid mineralization, etc. Violation of the microarchitecture of bone tissue is accompanied by the development of low-traumatic fractures and deformities, early osteoarthritis, the formation of contractures and chronic pain syndrome. Genetic studies of patients have expanded knowledge about the molecular signaling pathways that coordinate bone development and metabolism, the nature of disease inheritance, clinical features, and specific bone biomarkers. This article provides an overview of key cellular mechanisms, features of diagnosis and treatment of hereditary human diseases that affect the condition of bone tissue and skeleton: osteogenesis imperfecta, EhlersDanlos syndrome, Marfan syndrome, juvenile osteoporosis, hypophosphatasia, osteopetrosis, progressive diaphyseal dysplasia, mucopolysaccharidoses, achondroplasia, multiple hereditary exostoses. Doctors of different specialties can encounter these diseases, and making a correct diagnosis will make it possible to determine the correct algorithm for patient management and begin timely treatment, the ability to prevent the development of severe complications, improve the quality of life of patients, restore maximum working capacity and reduce the percentage of disability.
Multidisciplinary approach in the treatment of hyperplastic diseases of the uterus
Authors: Dobrokhotova Ju. E. , Markarov A. E. , Ponimanskaya M. A. , Apresyan S. V. , Khlynova S. A. , Dimitrova V. I. , Papoyan S. A. , Markova E. A. , Slyusareva O. A. 
Published: May 2024

Introduction. Uterine fibroids are ranked second and endometriosis is ranked third in the gynaecological pathology pattern. Uterine fibroids and endometriosis are among the most common diseases of the female genitalia and occur in every 4–5 gynaecological patients.Aim. To improve a multidisciplinary approach to the choice of surgical organ-preserving treatment strategies in hyperplastic diseases of the uterus using occlusion techniques.Materials and methods. A cohort prospective comparative study examined a multidisciplinary approach to the choice of surgical organ-preserving treatment strategies in uterine hyperplastic hysteropathies using occlusion techniques.Results. The study showed that uterine artery embolization is indicated if FIGO 2–5 fibroids’ size is > 4 cm in patients who are not planning pregnancy. The laparoscopic myomectomy with temporary uterine artery occlusion is provided if FIGO 2–6 fibroids’ size is from 6.0 to 8.0 cm, the laparoscopic myomectomy with temporary balloon occlusion of the internal iliac arteries is the procedure of choice if fibroids’ size is from 8.0 to 12.0 cm and they are located in the cervical-isthmus region and in areas of vascular bundles, and vaginal myomectomy with temporary balloon occlusion of the common iliac arteries is performed if FIGO 8 fibroids’ size is > 4 cm and they are located in the cervix. If adenomyosis nodes’ size is from 4.0 to 6.0 cm, they are removed using laparoscopic access with temporary occlusion of the uterine arteries; if adenomyosis nodes’ size is ≥ 6.0 cm, they are removed using laparoscopic access with temporary balloon occlusion of the internal iliac arteries.Conclusion. The multidisciplinary approach in the treatment of hyperplastic diseases of the uterus is regarded as optimal.
Profissionais de saúde do serviço noturno: hábitos alimentares, causas e consequências
Authors: Da Silva Cristina , Tatiana de Souza  , Herlander Costa Alegre da Gama Afonso  , Júlio Cesar Santos da Silva  , Maria da Silva Vieira Pacheco Janaína 
Published: May 2024

RESUMO: Delimitação do tema: Atualmente, são visíveis os impactos provocados na população em função de uma alimentação desregulada, e quando o assunto se refere aos profissionais de saúde, não é diferente. Por diversos motivos, uma quantidade de trabalhadores de períodos noturnos que atuam na área da saúde optam pela ingestão de determinados grupos alimentares ricos em sódio, gordura e açúcares. Justificativa: Associado ao trabalho noturno, como demonstrado por pesquisas, esses hábitos estão associados ao aumento do índice de massa corporal e doenças crônicas não transmissíveis-DCNT, o que leva a determinadas incapacidades e ao absenteísmo. Evitar essas práticas pode contribuir para aumento da produtividade laboral. Objetivo Geral: Esse estudo analisa os fatores que interferem no acesso à alimentação saudável desses colaboradores, à fim de evidenciar os impactos advindos da má alimentação durante a atuação nesse período. Metodologia: Trata-se de uma pesquisa qualitativo-descritiva, o qual foram realizadas buscas na literatura sobre a alimentação e qualidade de vida dos profissionais de saúde, inferidas a partir de entrevistas realizadas por WhatsApp, tendo sido lhes envido um formulário do Google Forms contendo 10 questões estruturado de forma aberta e fechada. A amostragem investigada é não probabilística, pois a seleção dos elementos que compôs a amostra dependeu do julgamento do entrevistador. Discussão e resultados: Dentre as respostas, obtiveram-se: 63,6%dos entrevistados foram técnicos de enfermagem, 25% enfermeiros, 4,8% médicos e 6% outros; a maioria do sexo feminino (72,7%), na faixa etária entre 18 e 30 anos (59,1%), mães (59,1%); sendo que 84,1% relataram ter aumentado de peso corporal após admissão no trabalho noturno, em virtude de dificuldade de acesso a alimentos adequados. Conclusão: Conclui-se que a má alimentação prejudica a saúde dos profissionais que atuam em período noturno, sendo urgente a necessidade de se investir no acesso e na mudança dos hábitos alimentares dos mesmos.
A Pandemia de Covid-19 Interferiu no Conhecimento em Ressuscitação Cardiopulmonar Pré-Hospitalar por Alunos de Medicina?
Authors: Picone Borges de Aragão Ivana , Marques dos Santos Sara Cristine , Picone Borges dos Anjos Ivan Lucas , de Souza Cortes Junior João Carlos , Brito de Aragão Alexandre Augusttus , Rodrigues Braga Neto Antonio 
Published: May 2024

A parada cardiorrespiratória (PCR) consiste na interrupção abrupta da contração cardíaca e ejeção do fluxo sanguíneo aos órgãos do corpo, incluindo o próprio coração seguido de óbito. As causas podem ser pela disfunção mecânica ou elétrica do coração. A ressuscitação cardiopulmonar (RCP) começou a ser discutida e ganhar visibilidade no século 18, através da toracotomia, evoluindo, no século 19, para as técnicas de compressões torácicas e abertura de vias aéreas combinadas, momento em que a American Heart Association (AHA) introduziu o primeiro guia de atendimento e suporte cardiopulmonar, dando início aos treinamentos direcionados a população. O objetivo foi avaliar e comparar o conhecimento do estudante de medicina sobre identificação da PCR e técnica da RCP no atendimento pré-hospitalar segundo o período pandêmico de COVID-19. Estudo observacional e transversal, quantitativo e qualitativo em alunos do primeiro período de medicina, através de questionário anônimo com 21 perguntas sobre conhecimento teórico em RCP. Foram divididos entre o período pré-pandemia (Pré-P) COVID-19 (entre 2018 e 2019); per-pandêmico (Per-P) (2020 e 2021); pós-pandemia (Pós-P) (2022) para comparação do conhecimento. Total de 536 questionários avaliados. Houve 296 (55,2%) alunos no grupo Pré-P, 171 (31,9%) no Per-P e 69 (12,9%) no Pós-P. O grupo Pós-P demonstrou maior conhecimento em relação ao primeiro, segundo e terceiro elos na cadeia de sobrevivência, em relação à região e a profundidade das compressões torácicas, sobre o que é um desfibrilador externo automático (DEA) e sobre identificar uma vítima de PCR. Porém, o grupo Pré-P informou saber manusear um DEA e aptidão em realizar uma RCP. O serviço de socorro ser acionado e o telefone de contato; a superfície onde a vítima deve estar apoiada; o posicionamento das mãos do socorrista no tórax da vítima e do socorrista foram semelhantes, contando com a maioria, entre os grupos. A minoria dos grupos conhecia a diferença entre os ritmos chocáveis e não chocáveis e sua importância em relação ao uso do DEA de forma semelhante. O grupo Pós-P demonstrou maior conhecimento sobre as técnicas de RCP, sobre o DEA e reconhecimento as PCR. Porém, o grupo Pré-P demonstrou ser mais capaz em proceder uma RCP e manusear o DEA, apesar do menor conhecimento nas respostas sobre as técnicas.
Palavras chaves: Reanimação Cardiopulmonar. Parada Cardíaca. Emergências. Estudantes de Medicina. Conhecimento. Cardioversão Elétrica. Desfibriladores externo automático
Percepção da saúde bucal de caminhoneiros que trafegam pelas rodovias BR 116 e BR 324 no município de Jequié, Bahia
Authors: Santos Maria Vitória Araújo , Cafezeiro Amanda Sales , Yarid Sérgio Donha 
Published: May 2024

Introdução: a condição de trabalho de caminhoneiros, com as longas e ininterruptas jornadas, compromete os cuidados com a saúde e bem-estar desses profissionais. Objetivo: verificar a percepção em saúde bucal de caminhoneiros que trafegam pelas rodovias BR 116 e BR 324 no município de Jequié – Bahia, no ano 2019. Método: aplicação de questionário com 7 perguntas sobre saúde bucal aos motoristas de veículos de cargas em geral que trafegam pelas Rodovias BR 116 e BR 324, durante a realização do evento Saúde na BR pelo Núcleo de Pesquisa em Bioética e Espiritualidade (NUBE). Resultados: a maior parte dos caminhoneiros entrevistados realizam a higienização bucal (96,3%; n=82), principalmente utilizando escova e creme dental, com frequência de três vezes ao dia (51,2%; n=82). A predominância de visita ao dentista foi de uma vez por ano (34,1%; n=82) da amostra. Sobre o uso e necessidade de prótese, 67,9% (n=81) não utilizam e 32,1% (n=81) utilizam prótese parcial removível, prótese total, prótese sobre implante ou prótese fixa. Conclusão: conclui-se que caminhoneiros executam o autocuidado e higienização da cavidade oral de forma regular e por isso deve ocorrer a continuidade das atividades de promoção e prevenção para o cuidado e manutenção da saúde bucal.
Palavras - Chaves: Saúde do Trabalhador; Saúde Bucal; Estilo de Vida.
Adherence to 24-Hour Movement Guidelines Among Chinese Older Adults: Prevalence, Correlates, and Associations With Physical and Mental Health Outcomes
Authors: Liang Wei , Wang Yanping , Huang Qian , Shang Borui , Su Ning , Zhou Lin , Rhodes Ryan E , Baker Julien Steven , Duan Yanping 
Published: May 2024

Background
It is known that 24-hour movement behaviors, including physical activity (PA), sedentary behavior (SB), and sleep, are crucial components affecting older adults’ health. Canadian 24-hour movement guidelines for older adults were launched in 2020, emphasizing the combined role of these 3 movement behaviors in promoting older adults’ health. However, research on the prevalence and correlates of guideline adherence and its associations with health-related outcomes is limited, especially among Chinese older adults.

Objective
This study aimed to investigate the prevalence and correlates of meeting 24-hour movement guidelines among Chinese older adults. Furthermore, this study aimed to examine the associations of guideline adherence with older adults’ physical and mental health outcomes.

Methods
Using a stratified cluster random sampling approach, a total of 4562 older adults (mean age 67.68 years, SD 5.03 years; female proportion: 2544/4562, 55.8%) were recruited from the latest provincial health surveillance of Hubei China from July 25 to November 19, 2020. Measures included demographics, movement behaviors (PA, SB, and sleep), BMI, waist circumference, waist-hip ratio (WHR), percentage body fat (PBF), systolic and diastolic blood pressure, physical fitness, depressive symptoms, and loneliness. Generalized linear mixed models were employed to examine the associations between variables using SPSS 28.0 (IBM Corp).

Results
Only 1.8% (83/4562) of participants met all 3 movement guidelines, while 32.1% (1466/4562), 3.4% (155/4562), and 66.4% (3031/4562) met the individual behavioral guidelines for PA, SB, and sleep, respectively. Participants who were older, were female, and lived in municipalities with lower economic levels were less likely to meet all 3 movement guidelines. Adhering to individual or combined movement guidelines was associated with greater physical fitness and lower values of BMI, waist circumference, WHR, PBF, depressive symptoms, and loneliness, with the exception of the relationship of SB+sleep guidelines with loneliness. Furthermore, only meeting SB guidelines or meeting both PA and SB guidelines was associated with lower systolic blood pressure.

Conclusions
This is the first study to investigate adherence to 24-hour movement guidelines among Chinese older adults with regard to prevalence, correlates, and associations with physical and mental health outcomes. The findings emphasize the urgent need for promoting healthy movement behaviors among Chinese older adults. Future interventions to improve older adults’ physical and mental health should involve enhancing their overall movement behaviors and should consider demographic differences.
Education in Laparoscopic Cholecystectomy: Design and Feasibility Study of the LapBot Safe Chole Mobile Game
Authors: Noroozi Mohammad , St John Ace , Masino Caterina , Laplante Simon , Hunter Jaryd , Brudno Michael , Madani Amin , Kersten-Oertel Marta 
Published: May 2024

Background
Major bile duct injuries during laparoscopic cholecystectomy (LC), often stemming from errors in surgical judgment and visual misperception of critical anatomy, significantly impact morbidity, mortality, disability, and health care costs.

Objective
To enhance safe LC learning, we developed an educational mobile game, LapBot Safe Chole, which uses an artificial intelligence (AI) model to provide real-time coaching and feedback, improving intraoperative decision-making.

Methods
LapBot Safe Chole offers a free, accessible simulated learning experience with real-time AI feedback. Players engage with intraoperative LC scenarios (short video clips) and identify ideal dissection zones. After the response, users receive an accuracy score from a validated AI algorithm. The game consists of 5 levels of increasing difficulty based on the Parkland grading scale for cholecystitis.

Results
Beta testing (n=29) showed score improvements with each round, with attendings and senior trainees achieving top scores faster than junior residents. Learning curves and progression distinguished candidates, with a significant association between user level and scores (P=.003). Players found LapBot enjoyable and educational.

Conclusions
LapBot Safe Chole effectively integrates safe LC principles into a fun, accessible, and educational game using AI-generated feedback. Initial beta testing supports the validity of the assessment scores and suggests high adoption and engagement potential among surgical trainees.
Combination of Curcuminoids and Acupressure for Inflammation and Pain in Older People with Osteoarthritis Genu: Protocol for a Randomized Controlled Trial
Authors: Mahanani Srinalesti , Kertia Nyoman , Madyaningrum Ema 
Published: May 2024

Background
Curcuminoids and acupressure have beneficial effects in reducing pain and inflammation in patients with osteoarthritis. However, only a few clinical trials are investigating biomarkers to prove this objectively.

Objective
This study aims to investigate the effect of acupressure and curcuminoids on inflammatory markers and pain in older people with osteoarthritis genu.

Methods
A randomized controlled trial (RCT) was conducted among older people with osteoarthritis. All participants were randomized to a group that received 30 mg of curcuminoids in turmeric extract capsules and acupressure (group 1) or a group that received a placebo and sham acupressure (group 2) for 3 weeks.

Results
The study was approved by the research ethics board; ClinicalTrials.gov reviewed this protocol. The extracts were manufactured from May 2023 to June 2023. Participant recruitment was conducted in September and October 2023; a total of 72 participants aged 60 years or older participated, of whom 75% (n=54) were female. Data were analyzed in April 2024, and dissemination of results is expected by the end of 2024.

Conclusions
Primary outcomes were assessed at baseline and after the intervention. Relationships were assessed with inflammatory markers, endorphin hormones, and blood level of cycloxygenase-2 hormone. Additionally, secondary outcomes included pain, ability to perform activities of daily living, and quality of life. The beneficial effects that may be found in this trial may be exceptionally relevant in clinical practice, justifying this scientific inquiry. The benefits of herbs and acupressure can be helpful as additional options in treating inflammation and pain in patients with osteoarthritis.

Trial Registration
ClinicalTrials.gov NCT06105840; https://clinicaltrials.gov/study/NCT06105840

International Registered Report Identifier (IRRID)
DERR1-10.2196/54970
Research on Traditional Chinese Medicine: Domain Knowledge Graph Completion and Quality Evaluation
Authors: Liu Chang , Li Zhan , Li Jianmin , Qu Yiqian , Chang Ying , Han Qing , Cao Lingyong , Lin Shuyuan 
Published: May 2024

Background
Knowledge graphs (KGs) can integrate domain knowledge into a traditional Chinese medicine (TCM) intelligent syndrome differentiation model. However, the quality of current KGs in the TCM domain varies greatly, related to the lack of knowledge graph completion (KGC) and evaluation methods.

Objective
This study aims to investigate KGC and evaluation methods tailored for TCM domain knowledge.

Methods
In the KGC phase, according to the characteristics of TCM domain knowledge, we proposed a 3-step “entity-ontology-path” completion approach. This approach uses path reasoning, ontology rule reasoning, and association rules. In the KGC quality evaluation phase, we proposed a 3-dimensional evaluation framework that encompasses completeness, accuracy, and usability, using quantitative metrics such as complex network analysis, ontology reasoning, and graph representation. Furthermore, we compared the impact of different graph representation models on KG usability.

Results
In the KGC phase, 52, 107, 27, and 479 triples were added by outlier analysis, rule-based reasoning, association rules, and path-based reasoning, respectively. In addition, rule-based reasoning identified 14 contradictory triples. In the KGC quality evaluation phase, in terms of completeness, KG had higher density and lower sparsity after completion, and there were no contradictory rules within the KG. In terms of accuracy, KG after completion was more consistent with prior knowledge. In terms of usability, the mean reciprocal ranking, mean rank, and hit rate of the first N tail entities predicted by the model (Hits@N) of the TransE, RotatE, DistMult, and ComplEx graph representation models all showed improvement after KGC. Among them, the RotatE model achieved the best representation.

Conclusions
The 3-step completion approach can effectively improve the completeness, accuracy, and availability of KGs, and the 3-dimensional evaluation framework can be used for comprehensive KGC evaluation. In the TCM field, the RotatE model performed better at KG representation.