bluuebunny/crossref_metadata_2025_split huggingface dataset:
The efficacy and safety of MARS-PD: Meridian activation remedy system for Parkinson’s disease—A single-center, assessor and statistician-blinded, parallel-group randomized, controlled trial protocol
Authors: Park Miso S. , Park SangSoo , Kang Jie-Yoon , Jung In Chul , Yoo HoRyong 
Published: May 2024

Background
Parkinson’s disease (PD) patients face a substantial unmet need for disease-modifying interventions. Potential approaches such as exercise and acupuncture have been investigated to slow PD progression. To address this unmet need, we developed a novel therapeutic approach that integrates acupuncture and exercise: the Meridian Activation Remedy System for PD patients (MARS-PD). Building upon promising outcomes observed in our preliminary pilot study, where MARS-PD exhibited a large clinically important difference on the Movement Disorder Society Unified Parkinson’s Disease Rating Scale Part III (MDS-UPDRS Part III), we embark on a randomized controlled trial with the primary objective of examining the efficacy, safety, and economic impact of MARS-PD.

Methods
In this single-center, assessor and statistician-blinded, parallel-group randomized controlled trial, we aim to investigate the clinical efficacy of MARS-PD through 16 interventions administered over 8 weeks in 88 PD patients. Participants will be randomly assigned to the experimental (n = 44) or control (n = 44) groups. The experimental group will receive MARS-PD intervention alongside standard care, while the control group will solely receive standard care. The intervention period spans 8 weeks, followed by a 12-week post-intervention follow-up. The primary endpoint is the change in MDS-UPDRS Part III score from baseline to the conclusion of the 8-week intervention. Secondary outcomes encompass various assessments, including MDS-UPDRS, International Physical Activity Questionnaire Short Form, Parkinson Self Questionnaire, Parkinson’s Disease Sleep Scale, Timed Up and Go test, GAITRite metrics, Functional Near-Infrared Spectroscopy measurements, smart band outcomes, gut microbiome analysis results, and iris connective tissue texture.

Discussion
Previous studies by the authors have indicated MARS-PD’s safety and benefits for PD patients. Building upon this foundation, our current study aims to provide a more comprehensive and detailed confirmation of the efficacy of MARS-PD.

Trial registration
cris.nih.go.kr KCT0006646 –First posted on 7 October 2021; ClinicalTrials.gov NCT05621772 –First posted on 11 November 2022.
Sterile Cerebrospinal Fluid Ascites With High Serum Ascites Albumin Gradient Treated With Acetazolamide
Authors: Rosario Lora Dauris , Post Zoë , Mitchell Justin E. 
Published: May 2024

ABSTRACTCerebrospinal fluid (CSF) ascites is a rare cause of ascites that presents in patients with ventriculoperitoneal (VP) shunts, treated by conversion to a ventriculoatrial shunt. Our case describes a patient presenting with CSF ascites almost 40 years after VP shunt placement, with fluid analysis showing elevated serum ascites albumin gradient, and response to acetazolamide therapy. As shown in this case, CSF ascites can present with elevated serum ascites albumin gradient and should be kept a differential diagnosis. Acetazolamide can be considered as a potential alternative treatment in patients who are not candidates for a VP to ventriculoatrial shunt conversion.
Histomorfometri Arteri Koronaria Hewan Model Resistensi Insulin Pasca Pemberian Serbuk Kunyit (Curcuma longa) dan Telur Puyuh (Coturnix coturnix japonica)
Authors: Wardani Ikhnu Pawestri , Tana Silvana , Saraswati Tyas Rini 
Published: May 2024

Resistensi insulin merupakan awal dari prediabetes, menyebabkan absorbsi glukosa oleh sel menurun. Tubuh melakukan glukoneogenesis untuk mempertahankan kadar glukosa agar tetap normal. Glukoneogenesis yang terus menerus menyebabkan hiperglikemia yang beresiko aterosklerosis. Serbuk kunyit dapat menghambat aterosklerosis melalui mekanisme antioksidan. Telur puyuh tinggi HDL dan β-karoten dapat melakukan jalur balik transportasi kolesterol dan antiinflamasi. Penelitian bertujuan untuk mengetahui dan menganalisis pengaruh serbuk kunyit dan telur puyuh terhadap histomorfometri arteri koronaria hewan model resistensi insulin. Penelitian menggunakan rancangan acak lengkap dengan 5 perlakuan dan 8 ulangan. Langkah kerja penelitian yaitu aklimasi hewan model, penyiapan tikus resistensi insulin, pemeliharaan puyuh dan produksi telur, pemberian perlakuan terhadap hewan model, pembuatan preparat histologi dengan metode parafin, dan analisis data menggunakan uji ANOVA yang dilanjutkan uji Duncan. Hasil penelitian didapatkan bahwa D1 berbeda signifikan terhadap D0, D2, D3, dan D4. Serbuk kunyit dan telur puyuh mampu mengurangi plak pada arteri koronaria. Serbuk kunyit memiliki efek antioksidan, telur puyuh memiliki kandungan HDL yang tinggi dan β-karoten. Kesimpulan penelitian yaitu pemberian serbuk kunyit dan telur puyuh efektif dalam memperbaiki status resistensi insulin. Insulin resistance is the beginning of prediabetes, which causes decreased ability of cells to absorb glucose. The body performs gluconeogenesis to maintain normal glucose levels. Continuous gluconeogenesis causes hyperglycemia which is at risk of atherosclerosis. Turmeric powder can inhibit atherosclerosis through antioxidant mechanisms. Quail eggs contain high HDL and β-carotene can reverse cholesterol transport and anti-inflammatory pathways. This study aims to determine and analyze the effect of turmeric powder and quail eggs on the histomorphometry of the coronary arteries in insulin resistance models. The study used a completely randomized design with 5 treatments and 8 replications. The steps of the research were acclimation of animal models, preparation of insulin resistance rats, quail rearing and egg production, treatment of animal models, preparation of histology preparations using paraffin method, and data analysis using ANOVA test followed by Duncan's test. The results showed that D1 was significantly different from D0, D2, D3, and D4. Turmeric powder and quail eggs can reduce plaque in the coronary arteries. Turmeric powder has an antioxidant effect, quail eggs have a high content of HDL and β-carotene. The conclusion of the study is treatment with turmeric powder and quail eggs is effective in improving insulin resistance status.
Karakteristik Stomata dan Trikoma Lima Spesies Gulma Familia Asteraceae di Waduk Pendidikan Universitas Diponegoro
Authors: Julianti Mentari Annissa , Darmanti Sri , Haryanti Sri 
Published: May 2024

Familia Asteraceae merupakan kelompok tanaman dengan kemampuan adaptasi tinggi. Hal tersebut didukung oleh karakteristik struktur stomata dan trikomanya. Penelitian ini bertujuan untuk mengetahui karakteristik stomata dan trikoma lima spesies gulma dari familia Asteraceae yang tumbuh di Waduk Pendidikan Universitas Diponegoro. Kelima spesies gulma tersebut adalah Bandotan (Ageratum conyzoides L.), Kirinyuh (Chromolaena odorata L.), Ketul (Bidens pilosa L.), Gletang (Tridax procumbens L.), dan Sawilangit (Vernonia cinerea L.). Preparat anatomi epidermis daun dibuat dengan metode free-hand section. Data kualitatif dianalisis secara deskriptif, sedang data kuantitatif dianalisis dengan uji T. Hasil penelitian menunjukkan bahwa karakterisik stomata kelima spesies adalah stoma tipe anomositik, sel penutup berbentuk ginjal, dan letak stoma amfistomatik. Panjang stoma, lebar stoma dan densitas stomata bervariasi di kedua permukaan daun. Pada kelima spesies trikoma multiseluler dengan bentuk bervariasi diantara spesies. Trikoma non-glanduler ditemukan pada kelima spesies, sedangkan trikoma glanduler hanya terdapat pada B. pilosa L. Panjang dan densitas trikoma pada kelima spesies bervariasi di kedua permukaan daun. Hal tersebut menunjukkan bahwa berdasarkan stomanya, B. Pilosa L. mempunyai karakter yang paling berbeda diantara ke lima species tersebut. The Asteraceae family is a group of plants with high adaptability. This is supported by the structural characteristics of the stomata and trichomes. This research aims to determine the characteristics of the stomata and trichomes of five weed species from the Asteraceae family that grow in the Diponegoro University Education Reservoir. The five weed species are Bandotan (Ageratum conyzoides L.), Kirinyuh (Chromolaena odorata L.), Ketul (Bidens pilosa L.), Gletang (Tridax procumbens L.), and Sawilangit (Vernonia cinerea L.). Anatomical leaf epidermis preparations were made using the free-hand section method. Qualitative data were analyzed descriptively, while quantitative data were analyzed using the T test. The results showed that the characteristics of the stomata of the five species were anomocytic stoma, kidney-shaped guard cells, and amphistomatic stoma location. Stoma length, stoma width and stoma density vary on both leaf surfaces. In the five species the trichomes are multicellular with varying shapes between species. Non-glandular trichomes were found in all five species, while glandular trichomes were only found in B. pilosa L.. The length and density of trichomes in the five species varied on both leaf surfaces. This shows that based on its stoma, B. Pilosa L. has the most different characters among the five species.
Pengujian Potensi Cairan Omasum Sapi untuk Ketercernaan Tiga Jenis Bahan Organik sebagai Sumber Bioetanol Generasi Ke-2
Authors: Hastuti Endah Dwi , Amalia Riska , Izzati Munifatul 
Published: May 2024

Cairan omasum sapi mengandung berbagai microbiome yang dapat mendelignifikasi dan menghidrolisis selulosa sehingga berpotensi digunakan dalam pembuatan bioetanol G2 dari daun mangga, daun pisang, dan kapas. Penelitian ini bertujuan untuk menganalisis perbedaan pH, kadar gula, keanekaragaman microbiome, perubahan struktur anatomi daun mangga, daun pisang, dan kapas yang direndam dalam cairan omasum. Penelitian menggunakan Rancangan Acak Lengkap dengan 6 perlakuan, yaitu daun mangga omasum, kontrol daun mangga, daun pisang omasum, kontrol daun pisang, kapas omasum, dan kontrol kapas, masing-masing perlakuan dengan 3 ulangan. Parameter yang diamati adalah pH, kadar gula, dan microbiome yang dianalisis One-Way ANOVA dilanjutkan uji Duncan, serta struktur anatomi ketercernaan dianalisis secara kualitatif. Hasil penelitian menunjukkan cairan omasum sapi meningkatkan pH daun mangga, daun pisang, dan kapas dengan kadar gula daun mangga 1,33%, daun pisang 0% dan kapas 0,08%. Microbiome daun mangga omasum sebanyak 2,66 spesies, daun pisang omasum 3,58 spesies, dan kapas omasum 4,08 spesies. Ketercernaan anatomi daun mangga akibat cairan omasum ditandai adanya ruang antar sel pada parenkim, pada daun pisang tidak dijumpai stomata dan sel epidermis membesar, pada kapas lebih tipis dan tanpa torsi. Cow omasum fluid contains various microbiomes that can delignify and hydrolyze cellulose so it has potential to be used in making G2 bioethanol from mango leaves, banana leaves, and cotton. This research aims to analyze differences pH, sugar content, microbiome diversity, anatomical structure changes of mango leaves, banana leaves and cotton soaked in omasum fluid. The research used a Completely Randomized Design with 6 treatments are mango omasum leaves, control mango leaves, banana leaves omasum, control banana leaves, cotton omasum, and control cotton, each treatment with 3 replications. The parameters observed were pH, sugar content and microbiome which were analyzed by One-Way ANOVA followed by Duncan's test, and the anatomical structure of digestibility was analyzed qualitatively. The research results showed that cow omasum fluid increased the pH of mango leaves, banana leaves and cotton with the sugar content of mango leaves 1.33%, banana leaves 0% and cotton 0.08%. The microbiome of mango omasum leaves was 2.66 species, banana leaf omasum 3.58 species, and cotton omasum 4.08 species. The anatomical digestibility were caused by omasum liquid of mango leaves is characterized by intercellular spaces in the parenchyma, banana leaves have no stomata and enlarged epidermal cells, and cotton is thinner and without torsion.
Profil Lipid Tikus (Rattus norvegicus L.) Hiperlipidemia Setelah Terpapar Ekstrak Etanol Biji Mahoni (Swietenia mahagoni)
Authors: Isdadiyanto Sri , Sitasiwi Agung Janika , Mardiati Siti Muflichatun 
Published: May 2024

Pakan yang mengandung kadar tinggi lemak dapat menyebabkan hiperlipidemia yang merupakan salah satu faktor pemicu terjadinya perubahan profil lipid. Biji mahoni mengandung flavonoid yang mempunyai kemampuan sebagai agen hipoglikemik. Penelitian ini bertujuan untuk menganalisis pengaruh ekstrak etanol biji mahoni sebagai herba antihiperlipidemia pada tikus putih yang diinduksi ransum tinggi lemak. Tikus putih yang digunakan adalah tikus jantan galur Wistar dengan umur 2 bulan dan berat badan rata-rata kurang lebih 200g. Hewan uji dibagi menjadi 6 kelompok perlakuan dengan 5 ulangan yaitu: Kontrol negatif (P0) diberi ransum komersial; kontrol positif (P1: diberi ransum tinggi lemak); pengobatan P2 (P1+ simvastatin 8mg/g BB); dan P1+ dosis ekstrak etanol biji mahoni sebesar 70;140;280 mg/kg BB(P3;P4 dan P5). Variabel yang diamati adalah kadar kolesterol total, HDL, LDL dan TG. Analisis data menggunakan ANOVA dilanjutkan dengan uji Beda Nyata Terkecil (BNT) dengan tingkat kepercayaan 95% menggunakan software SPSS 10.0. Hasil penelitian menunjukkan bahwa pemberian ekstrak etanol biji mahoni (S. mahagoni) dapat meningkatkan kadar HDL, menurunkan kolesterol LDL dan TG serum darah tikus putih (Rattus norvegicus L.). Foods containing high levels of fat can cause hyperlipidemia which is one of the triggering factors for changes in lipid profiles. Mahogany seeds contain flavonoids which have the ability as hypoglycemic agents. This study aimed to analyze the effect of mahogany seed ethanol extract as an antihyperlipidemic herb in white rats induced by high-fat rations. The white rats used were male Wistar strain rats with the age of 2 months and the average BW of approximately 200g. The test animals were divided into 6 treatment groups with 5 replications, namely: Negative control (P0) was given a commercial ration; positive control (P1: given high-fat ration); P2 treatment (P1+ simvastatin 8mg/g BW); and P1+ the dose of ethanol extract of mahogany seeds of 70;140;280 mg/kg BW(P3;P4 and P5). The variables observed were total cholesterol, HDL, LDL and TG levels. Data analysis using ANOVA was followed by the Least Significant Difference (BNT) test with a 95% confidence level using SPSS 10.0 software. The results showed that the administration of ethanol extract of mahogany seeds (S. mahagoni) could increase HDL levels, reduce LDL cholesterol and TG blood serum white rats (Rattus norvegicus L.).
ANALISIS SPASIAL KERAPATAN VEGETASI KOTA AMBON BERBASIS NORMALIZED DIFFERENCE VEGETATION INDEX (NDVI)
Authors: Lasaiba Mohammad Amin , Tetelepta Edward Gland 
Published: May 2024

Perencanaan dan pengelolaan kota merupakan hal yang kompleks sebagai dampak dari proses urbanisasi yang mempengaruhi tutupan lahan dan terkait erat dengan aktivitas manusia yang secara efektif mencerminkan atribut sosial ekonomi. Identifikasi yang akurat pada pola tutupan lahan perkotaan sangat penting untuk optimasi rasional terhadap struktur perkotaan dan memainkan peran kunci dalam terhadap berbagai perubahan yang memengaruhi ekosistem dan keanekaragaman hayati. Tujuan penelitian yang akan dicapai yaitu untuk menganalisis kerapatan vegetasi Kota Ambon berbasis Normalized Difference Vegetation Index (NDVI), dengan penggunaan data spasial penginderaan jauh citra satelit Landsat 8 OLI/TIRS Path 109 Row 63. Hasil penelitian yang dilakukan dengan menggunakan citra penginderaan jauh Landsat 8 OLI/TIRS perekaman 24 Maret 2022 Kota Ambon diklasifikasikan menjadi 5 kelas kerapatan vegetasi. Tingkat kerapatan tidak terinterpretasi (awan) memiliki luas 302,68 Ha (0.9%), Tingkat kerapatan tidak rapat memiliki luas 716,33 Ha (2.7%), Tingkat kerapatan cukup rapat memiliki luas 1367 Ha (4.2%), Tingkat kerapatan rapat memiliki luasan 3.154,70 Ha (9.7%), Tingkat kerapatan sangat rapat memiliki luasan 27.026,43 Ha (83%).
Ruderal vegetation of Ukraine: classes Galio-Urticetea Passarge ex Kopecký 1969 and Bidentetea R.Tx. et al. ex von Rochow 1951
Authors: Dubyna Dmytro Vasylovych , Dziuba Tetiana Pavlivna , Iemelianova Svitlana Mykolaivna , Felbaba-Klushyna Lubov Mykhailivna , Tymoshenko Pavlo Andriovych 
Published: May 2024

The current state and syntaxonomic structure of anthropogenic vegetation of the classes Galio-Urticetea and Bidentetea are revealed. The class Galio-Urticetea is represented by 3 phytosociological orders, 6 alliances, and 32 associations. The class Bidentetea unites 8 plant associations of 1 order and 2 alliances. The territorial differentiation of the studied plant communities is caused by the limiting factors: soil moisture and the changing hydrological regime. Thus the phytocoenoses of these classes are confined to the natural zones of Polissia and forest-steppe. Based on detrended correspondence analysis, the leading factors differentiating vegetation units were identified. Within the class Galio-Urticetea, they include the continentality of climate, precipitation regime, and concentration of mineral nitrogen in the soil. The factors of major significance for Bidentetea were soil moisture and the concentration of mineral nitrogen in the substrate.
Rosyjska tożsamość – pro et contra
Authors: Dobieszewski Janusz 
Published: May 2024

В статье рассматривается проблема исторической (культурной, национальной) идентичности России в понимании Петра Чаадаева, Владимира Соловьева и Федора Достоевского. Во всех трех проектах мы имеем дело с явно универсальными идеями. Однако далее в статье утверждается, что в этой русской универсалистской идеи и построенного на ней видения российской идентичности есть и более темная, сомнительная и даже опасная сторона. Эта идея может привести к решениям, к проецированию поспешных, опрометчивых, не столько ограниченных тяжестью жестких реалий, сколько не учитывающих реалий, трактующих их как почти сплошь пластичных и поддающихся давлению творческой и действенной субъективности. Это часто принимало форму сомнительного мессианства, избранности, особых сил, которые во имя спасительного или даже должного будущего не должны считаться с правилами и предписаниями текущего мира; это привело к таким видениям счастья, к которому принято принуждать, не избегать в его реализации от порабощения и преступления.
Exploring the Ethnic Cultural Integration Path of Immigrant Communities Based on Ethnic Inter-Embedding
Authors: Tian Zitong , Li Qiusheng 
Published: May 2024

Abstract
Facing the ethnic-cultural conflict in the relocation process and to promote ethnic-cultural integration, this study takes the ethnic interlocking communities in Guizhou Province as an example and uses research methods such as interviews and observation to collect data. The study also analyzes the influencing factors of cultural integration through regression analysis and proposes relevant measures. The results of regression analysis showed that cultural belonging, social support, community participation, and linguistic communication skills had a significant positive effect on ethnocultural integration while existing interpersonal relationships and identity had a significant negative effect on ethnocultural integration, with interpersonal relationships having the greatest effect on immigrants’ cultural integration, with a correlation coefficient of −0.260, followed by was the sense of cultural belonging with a regression coefficient of 0.240. Social support, language communication skills, community involvement, and identity were slightly less influential. Overall, the satisfaction levels after the migration were higher than before. Among them, the average satisfaction of immigrants with their income status before migration was 1.15. By building cultural exchange platforms and conducting targeted vocational training, new ideas have been provided for the integration of ethnic cultures in ethnic fusion communities. Research methods can effectively alleviate ethnic-cultural conflicts and promote ethnic-cultural integration.
Cell wall composition of Camellia oleifera Abel. shell: new insights into its composition distribution and ultrastructure
Authors: Huang Jiawei , Lin Xiuyi , Zhang Weiwei , Guan Litao , Xu Jiangtao , Gu Jin , Zhou Yonghui , Hu Chuanshuang 
Published: May 2024

Abstract

Camellia oleifera Abel. shell (COS) is an agricultural waste in quantities exceeding a million tons annually. The ultrastructure of the COS cell wall and the distribution of lignocellulose components were investigated. The microscopic results showed that COS contains two types of cells, sclerenchyma cells (SC) and parenchyma cells (PC). SC contained 50.4 % hemicellulose, 17.6 % cellulose and 30.9 % lignin while PC contained 35.2 % hemicellulose, 23.7 % cellulose and 35.0 % lignin. The distribution of lignocellulose components in COS is non-homogeneous. Lignin is alternately distributed with polysaccharides in the PC wall. In SC, hemicellulose is mainly present in the secondary wall S2, while lignin was mainly found in the compound middle lamella, and cellulose mainly exists in the secondary wall, S3. A comprehensive model of the cell wall ultrastructure and lignocellulose distribution of COS was given. This study provides a fundamental understanding of COS cell walls and can aid in the future graded utilization of COS.
Convergence of matrix transform means with respect to the Walsh–Kaczmarz system
Authors: Blahota István , Nagy Dóra 
Published: May 2024

Abstract
In this paper the Walsh system will be considered in the Kaczmarz rearrangement. We estimate the difference between matrix transform means of Walsh–Kaczmarz–Fourier series and the corresponding function in norm, and the upper estimation is given by the modulus of continuity of the function. We also prove norm convergence with similar conditions.
Poly-3,4-dihydroxybenzylidenhydrazine, a different analogue of polydopamine
Authors: Terenti Natalia , Fălămaş Alexandra , Bogdan Diana , Filip Claudiu , Vulcu Adriana , Petran Anca 
Published: May 2024

Abstract
In this article, 3,4-dihydroybenzylidenehydrazine is synthesized for the first time, and its properties as a dopamine analogue for polymerization are investigated. Using an oxidative polymerization reaction, the reaction mechanism as well as the coating ability of the new polymer is determined and compared to that of polydopamine. The polymerization reactions were performed in a mixture of methanol–water with NaIO4 as an oxidation reagent. The polymer was used as a coating on both glass surfaces with a thickness of ∼5 nm as determined by AFM, as well as on TiO2 nanoparticles. For the latter, SEM/TEM and the pH-dependent variation of zeta potential were measured. As a free polymer, poly-3,4-dihydroxybenzylidenhydrazine was investigated by UV-Vis, ss-NMR, and FTIR, and a variety of monomeric units were found in the polymer matrix. The solubility in methanol or DMSO of the monomer and the slight solubility of the polymer allowed us to study the fluorescence and cyclic voltammetry properties for both the monomer and polymer.