bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prior use of extreme weight‐control behaviors in a community sample of women with binge eating disorder or subthreshold binge eating disorder: A descriptive study
Authors: Mond Jonathan M. , Peterson Carol B. , Hay Phillipa J. 
Published: June 2009

AbstractObjective and MethodThe prior occurrence of regular extreme weight‐control behaviors was examined in a community sample of women (n = 27) with binge eating disorder (BED) or subthreshold BED.ResultsApproximately two thirds of participants (65.4%) reported the prior use of either purging at least weekly or nonpurging behaviors three or more times per week, for a period of 3 months or more, whereas 38.5% of participants reported either purging at least twice weekly or nonpurging behaviors five or more times per week. Comparatively few participants (11.1%) had ever met formal diagnostic criteria for BN.DiscussionConsiderable overlap be‐tween disorders characterized by binge eating in the absence of extreme weight‐control behaviors and those characterized by extreme weight‐control behaviors in the absence of binge eating may be apparent when a longitudinal perspective is taken. Caution needs to be exercised in drawing conclusions concerning the extent of this overlap based on any one operational definition of the term “regular extreme weight‐control behaviors”. © 2009 by Wiley Periodicals, Inc. Int J Eat Disord 2010
Lack of TNFR2 expression by CD4+ T cells exacerbates experimental colitis
Authors: Dayer Schneider Johanna , Seibold Inge , Saxer‐Sekulic Nikolina , Paredes Bruno E. , Saurer Leslie , Mueller Christoph 
Published: June 2009

AbstractTNF plays fundamental roles in the induction and perpetuation of inflammation. The effects of TNF are mediated through TNF receptor (TNFR) 1 or 2. As these two receptors mediate different functions, selective targeting of one receptor may represent a more specific treatment for inflammatory disorders than the complete blocking of TNF. TNFR2 expression is up‐regulated in inflammatory bowel disease. Hence, we directly assessed the role of TNFR2 signaling in the CD4+ T‐cell transfer model of colitis using TNFR2−/− or WT mice as donors of colitogenic CD4+CD45RBhi T cells for transfer into syngeneic RAG2−/− or RAG2−/−TNFR2−/− recipient mice. Although the absence of TNFR2 expression by non‐lymphoid cells of the recipient mice does not influence the course of colitis, transfer of TNFR2−/− CD4+ T cells leads to an accelerated onset of disease and to more severe signs of inflammation. The enhanced colitogenic potential of TNFR2−/− CD4+ T cells is associated with reduced activation‐induced cell death, resulting in an increased accumulation of TNFR2−/− CD4+ T cells. Hence, TNFR2 signaling is crucial for the TNF‐dependent contraction of the disease‐inducing T cells. Therefore, a selective blocking of TNFR2 may lead to exacerbation rather than attenuation of T‐cell‐mediated inflammatory disorders.
Determination of 5‐Aminosalicylic Acid by Catalase‐Peroxidase Based Biosensor
Authors: Akkaya Alper , Altug Cagri , Pazarlioglu Nurdan Kasikara , Dinckaya Erhan 
Published: June 2009

Abstract5‐Aminosalicylic acid is an antiinflammatory drug used to treat inflammation of the digestive tract (Crohn's disease) and mild to moderate ulcerative‐colitis. 5‐Aminosalicylic acid is a bowel‐specific aminosalicylate drug. It was developed an amperometric biosensor for determination of 5‐aminosalicylic acid concentration and measurement technique is based on substrate‐competition. The biosensor is more suitable especially for routine 5‐aminosalicylic acid analysis because it is simple to construct and sensitive, specific and does not require any expensive apparatus. This enzyme based biosensor was made with a couple of enzymes which uses the same substrate. The electrode was developed to determine measurement conditions and also characterized.
Analysis of genomic dose‐response information on arsenic to inform key events in a mode of action for carcinogenicity
Authors: Gentry P. Robinan , McDonald Tracy B. , Sullivan Dexter E. , Shipp Annette M. , Yager Janice W. , Clewell Harvey J. 
Published: June 2009

AbstractA comprehensive literature search was conducted to identify information on gene expression changes following exposures to inorganic arsenic compounds. This information was organized by compound, exposure, dose/concentration, species, tissue, and cell type. A concentration‐related hierarchy of responses was observed, beginning with changes in gene/protein expression associated with adaptive responses (e.g., preinflammatory responses, delay of apoptosis). Between 0.1 and 10 μM, additional gene/protein expression changes related to oxidative stress, proteotoxicity, inflammation, and proliferative signaling occur along with those related to DNA repair, cell cycle G2/M checkpoint control, and induction of apoptosis. At higher concentrations (10–100 μM), changes in apoptotic genes dominate. Comparisons of primary cell results with those obtained from immortalized or tumor‐derived cell lines were also evaluated to determine the extent to which similar responses are observed across cell lines. Although immortalized cells appear to respond similarly to primary cells, caution must be exercised in using gene expression data from tumor‐derived cell lines, where inactivation or overexpression of key genes (e.g., p53, Bcl‐2) may lead to altered genomic responses. Data from acute in vivo exposures are of limited value for evaluating the dose‐response for gene expression, because of the transient, variable, and uncertain nature of tissue exposure in these studies. The available in vitro gene expression data, together with information on the metabolism and protein binding of arsenic compounds, provide evidence of a mode of action for inorganic arsenic carcinogenicity involving interactions with critical proteins, such as those involved in DNA repair, overlaid against a background of chemical stress, including proteotoxicity and depletion of nonprotein sulfhydryls. The inhibition of DNA repair under conditions of toxicity and proliferative pressure may compromise the ability of cells to maintain the integrity of their DNA. Environ. Mol. Mutagen., 2010. © 2009 Wiley‐Liss, Inc.
Adaptive finite elements with large aspect ratio for mass transport in electroosmosis and pressure‐driven microflows
Authors: Prachittham Virabouth , Picasso Marco , Gijs Martin A. M. 
Published: June 2009

AbstractA space–time adaptive method is presented for the numerical simulation of mass transport in electroosmotic and pressure‐driven microflows in two space dimensions. The method uses finite elements with large aspect ratio, which allows the electroosmotic flow and the mass transport to be solved accurately despite the presence of strong boundary layers. The unknowns are the external electric potential, the electrical double layer potential, the velocity field and the sample concentration. Continuous piecewise linear stabilized finite elements with large aspect ratio and the Crank–Nicolson scheme are used for the space and time
discretization of the concentration equation. Numerical results are presented showing the efficiency of this approach, first in a straight channel, then in crossing and multiple T‐form configuration channels. Copyright © 2009 John Wiley & Sons, Ltd.
The Laplace transform method for Burgers' equation
Authors: Chen Suqin , Wu Xionghua , Wang Yingwei , Kong Weibin 
Published: June 2009

AbstractThe Laplace transform method (LTM) is introduced to solve Burgers' equation. Because of the nonlinear term in Burgers' equation, one cannot directly apply the LTM. Increment linearization technique is introduced to deal with the situation. This is a key idea in this paper. The increment linearization technique is the following: In time level t, we divide the solution u(x, t) into two parts: u(x, tk) and w(x, t), tk⩽t⩽tk+1, and obtain a time‐dependent linear partial differential equation (PDE) for w(x, t). For this PDE, the LTM is applied to eliminate time dependency. The subsequent boundary value problem is solved by rational collocation method on transformed Chebyshev points. To face the well‐known computational challenge represented by the numerical inversion of the Laplace transform, Talbot's method is applied, consisting of numerically integrating the Bromwich integral on a special contour by means of trapezoidal or midpoint rules. Numerical experiments illustrate that the present method is effective and competitive. Copyright © 2009 John Wiley & Sons, Ltd.
Anterior cingulate cortical volumes and treatment remission of geriatric depression
Authors: Gunning Faith M. , Cheng Janice , Murphy Christopher F. , Kanellopoulos Dora , Acuna Jessica , Hoptman Matthew J. , Klimstra Sibel , Morimoto Shizuko , Weinberg James , Alexopoulos George S. 
Published: June 2009

AbstractBackgroundStructural abnormalities of the anterior cingulate cortex (ACC) may interfere with the interaction of cortical and limbic networks involved in emotional regulation and contribute to chronic depressive syndromes in the elderly. This study examined the relationship of regional anterior cingulate cortical volumes with treatment remission of elderly depressed patients. We hypothesized that patients who failed to remit during a 12‐week controlled treatment trial of escitalopram would exhibit smaller anterior cingulate gray matter volumes than patients who remitted.MethodsThe participants were 41 non‐demented individuals with non‐psychotic major depression. After a 2‐week single‐blind placebo period, subjects who still had a Hamilton Depression Rating Scale (HDRS) of 18 or greater received escitalopram 10 mg daily for 12 weeks. Remission was defined as a HDRS score of 7 or below for at least 2 consecutive weeks. The patient sample consisted of 22 depressed patients who achieved remission during the study and 19 depressed patients who remained symptomatic. High‐resolution magnetization‐prepared rapidly acquired gradient echo (MPRAGE) sequences were acquired on a 1.5 T scanner and regional ACC volumes were manually outlined (dorsal, rostral, anterior subgenual, and posterior subgenual).ResultsRepeated measure analyses revealed that patients who failed to remit following escitalopram treatment had smaller dorsal and rostral anterior cingulate gray matter volumes than patients who remitted, whereas subgenual cortical volumes did not differ between the groups.ConclusionsStructural abnormalities of the dorsal and rostral anterior cingulate may perpetuate late‐life depression. Copyright © 2009 John Wiley & Sons, Ltd.
Disagreement in preference for residential care between family caregivers and elders is greater among cognitively impaired elders group than cognitively intact elders group
Authors: Chau Pui Hing , Kwok Timothy , Woo Jean , Chan Felix , Hui Elsie , Chan Kam Che 
Published: June 2009

AbstractObjectivesThis study examined the predictive factors of preference for residential care in cognitively intact and impaired elders and their family caregivers. It was hypothesized that disagreement in preference for residential care between the elders and their caregivers was greater in the cognitively impaired.MethodsA cross‐sectional survey was conducted during June 2007 to March 2008 in Hong Kong, and 707 community‐dwelling elders aged 65 and above and 705 family caregivers were interviewed. Cognitively impaired elders were over‐sampled to give reliable estimates for that sub‐group. A structural questionnaire was used to collect data on preference for residential care and potential factors. Logistic regression was used to identify the predictors.ResultsMore cognitively impaired elder‐caregiver dyads (37.4%) had disagreement in preference for residential care than cognitively intact elder‐caregiver dyads (20.5%) (p < .001). From the elders' perspective, less preference for residential care was associated with cognitive impairment, whereas greater preference was associated with depression (for cognitively intact elders), more usage of community service and functional impairment. From the caregivers' perspective, greater preference for residential care was associated with greater caregiver burden, or care‐recipients having cognitive or functional impairment, or more usage of community services.ConclusionsCognitively intact elders were more likely to indicate preference for residential care than cognitively impaired elders. Elders, both cognitively intact and impaired, were less likely than their caregivers to indicate preference for residential care. Disagreement in preference for residential care between the elders and their caregivers was larger for the cognitively impaired group than the cognitively intact group. Copyright © 2009 John Wiley & Sons, Ltd.
What do Korean American immigrants know about Alzheimer's disease (AD)? The impact of acculturation and exposure to the disease on AD knowledge
Authors: Lee Sang E. , Lee Hee Yun , Diwan Sadhna 
Published: June 2009

AbstractObjectiveThe present study examined knowledge of Alzheimer's disease (AD) and factors related to the disease knowledge among Korean American immigrants.MethodsTwo‐hundred and nine middle‐aged and older Korean American immigrants completed a self‐administered questionnaire.ResultsKorean American immigrants had strong stigma about AD and interpreted the disease as a form of insanity. They considered memory loss and AD as a part of the aging process. They seriously lacked knowledge about the treatment, diagnosis and cause of AD. Those who were less acculturated and less exposed to AD were likely to have poorer AD knowledge.ConclusionsThere is a need to expand AD education efforts among Korean American immigrants because the views of stigmatization and normalization of AD combined with certain Asian cultural norms can be barriers to early recognition and intervention. Our study suggests knowledge areas of concentration in AD education and a segment of the population that AD education should target. Further research on symptom knowledge by the disease stages and causal beliefs is needed to better understand the existing views about AD in Korean American immigrants. Copyright © 2009 John Wiley & Sons, Ltd.
Screening for depression in elderly medical inpatients from rural area of Norway: prevalence and associated factors
Authors: Helvik Anne‐Sofie , Skancke Randi H. , Selbæk Geir 
Published: June 2009

AbstractAimThe present investigation screened for depression in order to assess the prevalence of depression and to study the associated factors with depression in elderly medically hospitalised patients from a rural area in Norway.MethodsA cross‐sectional study evaluated 484 (243 women) elderly medical inpatients with age range 65–101 (mean 80.7) years between September 2006 and August 2008 and used the Hospital Anxiety and Depression scale (HAD), Montgomery and Asberg Depression Rating Scale, the Mini‐Mental State Examination, Lawton and Brody's scale for self‐maintaining and instrumental activities of daily living.ResultsThe prevalence of current depression, depression score ≥8 at HAD, was for the total sample 10% of whom 78% was previously not diagnosed as having depression. The odds for depression were decreased for women aged 80 years or more while for men at the same age strata it was increased threefold. Age adjusted logistic regression analyses demonstrated an increased odds for depression for those who were in need of nursing assistance before hospitalisation, had lower level of physical functioning, had clinical anxiety symptoms and had higher number of medicaments at inclusion time.ConclusionThe prevalence of depression in medical hospitalised elderly from rural areas was lower than in most other hospital studies. However, most patients with depression were not previously recognised as being depressed. Copyright © 2009 John Wiley & Sons, Ltd.
Associations between stroke risk and cognition in normal aging and Alzheimer's disease with and without depression
Authors: Bangen Katherine J. , Delano‐Wood Lisa , Wierenga Christina E. , McCauley Ashley , Jeste Dilip V. , Salmon David P. , Bondi Mark W. 
Published: June 2009

AbstractBackgroundStroke risk factors have been increasingly implicated in the development of age‐related cognitive decline, the spectrum of vascular cognitive impairment, and, more recently, Alzheimer's disease (AD). In addition, depression and the apolipoprotein (APOE) ε4 allele have been reported to influence the association between stroke risk and cognition. However, few studies have described the relations among stroke risk, cognition, and APOE genotype in AD, and the findings have been equivocal.MethodsThirty cognitively normal older adults, 30 AD patients with depression, and 30 AD patients without depression were administered a comprehensive neuropsychological battery measuring several domains including memory, attention, language, visuospatial skills, executive functions, and speed of information processing. The Framingham Stroke Risk Profile (FSRP), a validated scale that was developed to predict 10‐year probability of stroke, was used to quantify stroke risk burden.ResultsAD patients with depression demonstrated greater stroke risk burden relative to the cognitively normal group and, across all participants, increased stroke risk was associated with poorer performance on memory and processing speed measures. Moreover, stroke risk accurately predicted AD diagnosis. Notably, there were no significant differences in stroke risk or cognitive performance between the AD participants with depression and those without depression.ConclusionGiven that many markers of stroke risk are modifiable or treatable, our findings have implications for assessment, prevention, and treatment of cognitive decline. Copyright © 2009 John Wiley & Sons, Ltd.
Alcohol use and the labor market in Uruguay
Authors: Balsa Ana I. , French Michael T. 
Published: June 2009

AbstractThis paper is one of only a few studies to examine potential labor market consequences of heavy or abusive drinking in Latin America and the first to focus on Uruguay. We analyzed data from a Uruguayan household survey conducted in 2006 using propensity score matching methods and controlling for a number of socio‐demographic, family, regional, behavioral health, and labor market characteristics. As expected, we found a positive association between heavy drinking and absenteeism, particularly for female employees. Counter to the findings for developed countries, our results revealed a positive relationship between heavy drinking and labor force participation or employment. This result was mostly driven by men and weakened when considering more severe measures of abusive drinking. Possible explanations for these findings are that employment leads to greater alcohol use through an income effect, that the Uruguayan labor market rewards heavy drinking, or that labor market characteristics typical of less developed countries, such as elevated safety risks or job instability, lead to problem drinking. Future research with panel data should explore these possible mechanisms. Copyright © 2009 John Wiley & Sons, Ltd.
Alternative Solid‐Phase Strategies for the Efficient Labelling of Peptides with (Bathophenanthroline)ruthenium(II) Complexes
Authors: Kramer Rolf A. , Bannwarth Willi 
Published: June 2009

Abstractmagnified imageTo increase the flexibility for the insertion of highly sensitive and robust [RuII(bathophenanthroline)] complexes into peptides, we have evaluated three different solid‐phase strategies (bathophenanthroline=4,7‐diphenyl‐1,10‐phenanthroline). Among these, insertion of the Ru‐complex‐modified lysine building block 9 turned out to be the method of choice (Scheme 5).
1,3‐Dipolar Cycloadditions of a 2‐Oxoethanenitrile Oxide Derived from (2R)‐Bornane‐10,2‐sultam to Electronically Modified 4,4′‐Disubstituted Stilbenes
Authors: Romanski Jan , Chapuis Christian , Jurczak Janusz 
Published: June 2009

Abstractmagnified imageThanks to its type‐II dipole nature, we were able to demonstrate the higher reactivity of the SO2/CO syn‐conformer for the uncatalyzed 1,3‐dipolar cycloaddition of the 2‐oxoethanenitrile oxide 2 derived from bornane‐10,2‐sultam to the symmetric 4,4′‐disubstituted trans‐stilbenes 3a–3i. The C(α)‐si dipolarophile πy approach along the CO bond precludes the use of the steric rules formerly expressed for this pseudo‐C2‐symmetric auxiliary. The observed diastereoselectivity is related to the electronic nature of the dipolarophile and may be predicted on the basis of its σpara Hammett constant. The absolute configuration was based on the X‐ray structure analysis of cycloadduct (4S,5S)‐4b, which exhibits an SO2/CO anti‐conformation. Finally, the results obtained with cis‐stilbene suggest a nonsynchronous mechanism.
Labdane and Tetranorlabdane Diterpenoids from Botryosphaeria sp. MHF, an Endophytic fungus of Maytenus hookeri
Authors: Yuan Lin , Zhao Pei‐Ji , Ma Juan , Lu Chun‐Hua , Shen Yue‐Mao 
Published: June 2009

Abstractmagnified imageFive new diterpenoids, named botryosphaerins A–E (1–5, resp.), including one labdane and four tetranorlabdane diterpenes, were isolated from the solid culture of the endophytic fungal strain Botryosphaeria sp. MHF of Maytenus hookeri, together with seven known diterpenoids, namely 13,14,15,16‐tetranorlabd‐7‐ene‐19,6β : 12,17‐diolide (6), acrostalidic acid (7), acrostalic acid (8), agathic acid (9), isocupressic acid (10), LL‐Z1271β (11), and CJ‐14445 (12). The structures of all compounds were established on the basis of comprehensive spectroscopic studies. The relative configurations of 1 and 2 were determined by single‐crystal X‐ray diffraction analyses. All compounds except 4 were evaluated for their inhibitory activities against several pathogenic bacterial and fungal strains. However, only compound 12 showed significant inhibitions against Candida albicans, Saccharomyces cerevisiae, and Penicillium avellaneum UC‐4376 with nystatin as a positive control.
Alkaloids from Aconitum barbatum var. puberulum
Authors: Sun Li‐Mei , Huang Hong‐Li , Li Wen‐Hai , Nan Ze‐Dong , Zhao Gui‐Xia , Yuan Cheng‐Shan 
Published: June 2009

Abstractmagnified imageThree new diterpenoid alkaloids, puberulines A–C (1–3, resp.), and three new benzamide derivatives, puberulines D–F (4–6, resp.), as well as 16 known diterpenoid alkaloids were isolated from Aconitum barbatum var. puberulum. The structures of the new compounds were established on the basis of spectral data (IR, EI‐MS, HR‐ESI‐MS, HR‐EI‐MS, 1H‐ and 13C‐NMR, DEPT, NOE, HMQC, 1H,1H‐COSY, HMBC, NOESY, and TOCSY).
Three New Limonoids from Melia toosendan
Authors: Zhou Chun‐Yan , Tang Hai‐Ying , Li Xiang , Sang Yi‐Shu 
Published: June 2009

Abstractmagnified imageIn order to find new and biologically active compounds, the constituents of the root bark of Melia toosendan were investigated, and three new limonoids, 29‐[(2‐methylbutanoyl)oxy]‐2α‐hydroxyamoorastatone (1), 1,3‐epi‐29‐[(2‐methylbutanoyl)oxy]‐2α‐hydroxyamoorastatone (2), and 1,3‐epi‐29‐[(2‐methylpropanoyl)oxy]‐2α‐hydroxyamoorastatone (3), were isolated from the root bark of Melia toosendan. Their structures were elucidated by means of extensive spectroscopic studies.
Two Novel Resveratrol Trimers from Dipterocarpus grandiflorus
Authors: Ito Tetsuro , Abe Naohito , Oyama Masayoshi , Tanaka Toshiyuki , Murata Jin , Darnaedi Dedy , Iinuma Munekazu 
Published: June 2009

Abstractmagnified imageTwo new resveratrol (=5‐[(E)‐2‐(4‐hydroxyphenyl)ethenyl]benzene‐1,3‐diol) trimers, grandiphenols C (1) and D (2), were isolated from the stem of Dipterocarpus grandiflorus (Dipterocarpaceae). The structures of 1 and 2 were elucidated by spectral analysis including 1D‐ and 2D‐NMR experiments and by computer‐aided molecular modeling. The NMR characteristics caused by the steric hindrance and the biogenetic relationship of the isolates are also discussed in this work.