bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of Benzofuran Analogue of Go6976, an Isoform‐Selective Protein Kinase C Inhibitor
Authors: Ma Da‐Wei , Zhang Yong‐Da , Zhang Xin‐Rong , Wu Shi‐Hui , Tao Feng‐Gang 
Published: September 2010

AbstractBased on the structure of Go6976, a known isoform‐selective protein kinase C inhibitor, a benzofuran analogue (1) was designed. This analogue was synthesized by coupling of benzofuran 3‐acetic acid and 8‐oxo‐tryptamine and subsequent intramolecular Dieckmann condensation, alkylation, oxidative photocydization and cyanation reaction of mesylate.
A Theoretical Study on Cucurbit[7]uril and Its Inclusion Complexation
Authors: Zhang Ke‐Chun , Mu Ting‐Wei , Liu Lei , Guo Qing‐Xiang 
Published: September 2010

AbstractPM3 and B3LYP/3–21g* calculations were performed on cucurbit[7]uril and its complex with protonated 2, 6‐bis (4, 5‐dihydro‐1 H‐imidazot‐2‐yl) naphthalene. The results agreed well with the experimental observations. It indicated that in addition to van der Waals interaction and hydrophobic effect, hydrogen bonding is also an important driving force for the molecular recognition of cucurbiturils.
Study of Thermokinetic Properties of Sodium Selenite on Bacillus thuringiensis Cry B by Microcalorimetry
Authors: Li Xi , Liu Yi , Zhao Ru‐Ming , Yu Zi‐Niu , Song‐Sheng Qu 
Published: September 2010

AbstractBy using an LKB2277 Bioactivity Monitor, the power‐time curves of Bacillus thuringiensis Cry B at 28°C effected by Na2SeO3 were determined. Some parameters, such as growth rate constants k, inhibitory ratio I, the maximum beat production rate Pmax, heat output Q, were obtained. Considering both the growth rate constant k and heat output Q, we found that a low concentration of Na2SeO3 had a promoting action on the growth of Bacillus thuringiensis Cry B, but a high concentration of Na2SeO3 had an inhibitory action. The toxicity of a toxicant can also be expressed as half inhibitory concentration IC50 of toxicant, i. e., 50% effective in this inhibition. The value of IC50 of Na2SeO3on Bacillus thuringiensis Cry B is 117 μg/mL. This microcalorimetric bioassay for cellular toxicity is based on metabolic heat evolution from cultured cells. The assay is quantitative, inexpensive, and versatile.
Contribution of Solvation Energy in Protein‐Peptide Recognition Systems
Authors: Li Fer , Li Wei , Shen Jia‐Cong 
Published: September 2010

AbstractThe contribution of solvation energy to guiding molecular recognition for six rigid protein‐peptide systems bad been evaluated by the variation in the number of the identified native‐like configurations and in the driving force of specific interaction resulting from the addition of the explicit solvation term in the force field function. The AMBER force field energy and the total energy including the force field energy and the WZS solvation energy were calculated for sampled configurations. The results obtained by the calculations of both force field and total energies were compared with each other. It suggests that the contribution of solvation energy is important to guiding the specific recognition of the systems in which the ligands possess larger hydrophobic or aromatic residues while the protein receptors provide the active surfaces with hydrophobic property.
Synthesis and Crystal Structure of [Nd(η6‐1, 3, 5‐C6H3Me3)‐(AlCl4)3](C6H6) and Structural Comparison of Ln(η6‐arene)‐(AlCl4)3
Authors: Yao Ying‐Ming , Zhang Yue , Shen Qi , Liu Qian‐Cai , Meng Qing‐Jin , Lin Yong‐Hua 
Published: September 2010

AbstractReaction of Ndcl3 with AlCl3 and mesitylene in benzene gives complex [Nd(η6‐1, 3, 5‐C6H3Me3)‐(AlCl4)3](C6H6) (1) which was characterized by elemental analysis, IR spectra, MS and X‐ray diffractions. The X‐ray determination indicates that 1 has a distorted pentagonal bipyramidal geometry and crystallizes in the monoclinic, space group P21/n with a = 0.9586(2), b = 1.1717(5), c = 2.8966(7) nm, β = 90.85 (2)°, V = 3.2529 (6) nm3,Dc= 1.573 g/cm3, Z = 4. A comparison of bond parameters for all the reported Ln (η6‐Ar) (AlCl4)3 complexes indicates that the bond distance of LaC is shortened with the increasing of methyl group on benzene and with the decreasing of radius of lanthanide ions.
Solid Solubility, Raman Spectra and Electrical Property of the Solid Solutions Ce1‐xNdxO2‐δ by Sol‐gel Route
Authors: Lin Xiao‐Min , Li Li‐Ping , Li Guang‐She , Su Wen‐Hui 
Published: September 2010

AbstractCe1‐xNdxO2‐δ (x = 0.05–0.55) solid solutions prepared by sol‐gel route were crystallized in a cubic fluorite structure. The solid limit was determined to be as high as x = 0.45. Raman spectra of the solid solutions with lower composition exhibited only one band, which was assigned to F2g mode. Increasing composition produced broad and asymmetric F2g mode with an appearance of low frequency tail. The new broad peak observed at higher frequency side of the F2g mode associated with the oxygen vacancy in the lattice. The impedance spectra of the solid solutions showed definitely ionic conduction, and Ce0.80Nd0.20O2‐δ solid solution possessed a maximum conductivity. At 500 °C, the conductivity and activation energy were 2.65 × 10−3S/cm and 0.82 eV, respectively.
Studies on Properties of Tetra‐p‐nitro‐tetra‐O‐alkylcalix[4]arenes
Authors: Lu Guo‐Yuan , Song Wei , Liu Min‐Hua , Liu Fang , Jin Chuan‐Min 
Published: September 2010

AbstractIbis paper reports the properties of the novel tetra‐p‐nitro‐tetra‐O‐alkyl‐calix[4]arenes (alkyl= n‐C4H9, 1; n‐C8H17 2; n‐C12H25, 3; n‐C16H33, 4). X‐ray crystallographic analysis and 1H NMR revealed that they exist as pinched‐cone conformation in crystal or cone conformation in solution. EFISH experiments at 1064 nm in CHCl3, indicated that tetra‐p‐nitro‐tetra‐O‐butyl‐calix[4]arene (1) has higher hyperpolarizability β, values than the corresponding reference compound p‐nitro‐phenyl butyl ether, without red shift of the charge transfer band. Compounds 2, 3 and 4 with longer alkyl chains can form monolayer at the air/water.
A New Two‐dimensional Cyano‐bridged Chromium (HI)‐Nickel (II) Bimetallic Assembly with Stair‐like Layers
Authors: Shen Xiao‐Ping , Yuan Ai‐Hua , Wu Qiang‐Jin , Huang Zi‐Xiang , Xu Zheng , Yu Yun‐Peng 
Published: September 2010

AbstractFrom the reaction of K3[Cr(CN)6] and [NiL](CIO4)2 (L= 1,8‐di(hydroxyethyl)‐l, 3, 6, 8, 10, 13‐hexaazacyclotetradecane), an infinite stair‐like layered assembly [NiL]3 [Cr‐(CN)6]2‐6.5H2O is obtained, in which each hexacyanochromate(III) ion connects three nickel(II) ions using three cis Of groups and the bridging cyanide ligands coordinate to the nickel ion in a trans fashion forming trans‐NiL(N°C)2 moieties.
Synthesis and Electronic Structures and Linear Optics of Solid State Compound SrB2O4
Authors: Zhang Hao , Cheng Wen‐Dan , Zheng Fa‐Kun , Chen Jiu‐Tong 
Published: September 2010

AbstractThe cluster (SrB2O4)2 existing in crystalline states is employed to model the electronic structure and linear optical properties of solid state compound SrB2O4. This compound is synthesized by high temperature solution reaction, and it crystallizes in the orthorhombic space group Pbcn with cell dimensions a = 1.1995(3), b = 0.4337(1), c = 0.6575(1) nm, V = 0.34202 nm3, and Z = 4, μ = 15.14 cm−1, Dcaled = 3.36 g/cm3. The dynamic refractive indices are obtained in terms of INDO/SCI following combination with the Sum‐Over‐States method. A width of the calculated gap is 4.424 eV between the valence band and conduction band, and the calculated average refractive index is 1.980 at a wavelength of 1.065 μm. The charge transfers from O2‐ anion orbitals to Sr2+cation orbitals make the significant contributions to linear polarizability in terms of analyses of atomic state density contributing to the valence and conduction bands.
A General Theoretical Model of Enthalpy‐Entropy Compensation
Authors: Liu Lei , Guo Qing‐Xiang 
Published: September 2010

AbstractEnthalpy‐entropy compensation remains a mystery in chemistry and biophysics. Recent study suggested that the solvent reorganization might constitute the physical origin of the compensation, which was unfortunately not widely applicable because compensation was also observed in solid phase reactions. In this study, a general theoretical model based upon strict mathematical deduction was presented, which indicated that the redistribution of the distinguishable subspecies might be the physical origin of the enthalpy‐entropy compensation in complex systems. As examples, the enthalpy‐entropy compensations in solvation and surface adsorption were discussed.
Synthesis and Characterization of Ethylenediammonium Molybdenum Thiocomplex [H3NCH2CH2NH3][Mo3S13]
Authors: Wang Ying , Chen Jie‐Sheng , Yuan Hong‐Ming , Shi Zhan , Yu Shao‐Fang , Chen Wei 
Published: September 2010

AbstractAn organo‐spaced molybdenum thiocomplex [ H3NCH2CH2‐NH3][Mo3S13] has been synthesized under hydrothermal condition and the structure of the compound was determined by single‐crystal X‐ray diffraction. The title compound crystallizes in the monoclinic space group C2/c with a = 1.81157 (18), b = 1.04549(9), c = 2.04892(19) nm, β= 107.184 (2)°, Z = 8 and V = 3.7074(6) nm3. The inorganic part of the compound consists of a Mo3 triangle capped by an apical μ3‐sulfur atom, with each Mo atom being also coordinated to one terminal disulfur ligand and two bridging disulfur ligands. The negative charges on the inorganic cluster are balanced by the diprotonated ethylenediamine cations [ H3NCH2CH2‐NH3]2+ located in the space between the clusters.
Effect of Solvent and Acid‐Base on Palladium (II)‐catalyzed Dicarbonylation of Terminal Acetylenes: a General, Efficient and Stereoselective Synthesis of Maleic Diesters and Maleic Anhydrides
Authors: Li Jin‐Hang , Jiang Huan‐Feng , Chen Ming‐Cai 
Published: September 2010

AbstractThe productions of maleic diesters and maleic anhydrides depend on the effect of solvent and acid‐base in palladium‐catalyzed dicarbonylation of terminal acetylenes. For primary and secondary alcohol in benzene, only maleic diesters were obtained stereospecifically from the dicarbonylation of acetylenes in the presence of PdCl2, CuCl2, and NaHCO3. For tertiary alcohols, maleic anhydrides were synthesized selectively.
A Novel Lanostanoid Lactone From the Alga Hypnea cerricornis
Authors: Xu Xiao‐Hua , Chen Xiao , Lu Jian‐Hua , Yao Guang‐Min , Li Yan‐Ming , Zeng Long‐Mei 
Published: September 2010

AbstractA novel lanostanoid lactone (1) was first isolated from the Alga Hypnea cerricornis collected from the Xisha Islands in the South China Sea. The structure of 1 was determined on spectral evidence as 5α‐lansta‐8‐en‐3β, 22°‐dihydroxy‐22 (R), 24 (S)‐lactone.
Studies on the Novel Calix [4] pyrrole and Its High Selectivity for p‐Nitrophenol
Authors: Su Xun‐Cheng , Zhu Shou‐Rong , Lin Hua‐Kuan , Chen Yun‐Ti 
Published: September 2010

AbstractSynthesis of novel neutral molecule receptor calix [4] pyrrole (2) from pyrrole and tropinone has been described and its ability of binding neutral molecules was tested. Spectroscopic titrations indicate that receptor 2 shows the highest selectivity for p‐nitrophenol among m,o,p‐nitrophenols due to the coincidence between the host's binding sites and the guest's geometry.
Microwave Assisted Synthesis of Pyridone Derivatives
Authors: Tu Shu‐Jiang , Deng Xu , Shi Da‐Qing , Gao Yuan , Feng Jun‐Cal 
Published: September 2010

AbstractA series of pyridone derivatives were synthesized by the reaction of aromatic aldehydes, 1,3‐dicarbonyl compounds and ammonium acetate under microwave irradiation in the absence of solvent. The reactions were completed within 3‐5 min to give the desired products in 72.4‐86.2% yields.
Promotion Effects of Nickel Catalysts of Dry Reforming with Methane
Authors: Yan Zi‐Feng , Ding Rong‐Gang , Liu Xin‐Mei , Song Lin‐Hua 
Published: September 2010

AbstractThe promotion effects of nickel catalyst of dry reforming with methane were extensively investigated by means of XRD, SEM, EDX, N2‐adsorption and H2‐adsorption. XRD characterization indicated that good dispersion of nickel oxide and MgO promoter is achieved over γ‐Al2O3 support. Addition of MgO promoter effectively retards the formation of NiAl2O4 phase. SEM and EDX analysis exhibited that the addition of rare‐earth metal oxide CeO2 effectively promotes the Ni metal dispersion on the surface of the catalysts despite of undesirable self‐dispersion of CeO2 promoter. Furthermore, the nickel component is gradually dispersed on the surface of the support following the exposure to reaction gas mixture for a period of time. The addition of MgO inhibited the self‐dispersion and promotion effect of CeO2 on Ni dispersion on the catalysts. H2 chemisorption revealed that the addition of the alkaline oxide MgO promoter significantly prohibits the metal dispersion on the catalyst. Inappropriate promoter addition can result in sharp decrease of the metal dispersion, N2‐adsorption indicated that oxide promoter was mostly concentrated on the outer layer of the alumina support while the nickel metal was generally dispersed in the support pores. Addition of promoters contributed to more reduction in mesopore volume.
Synthesis, Relaxivity and MRI Enhancement of Linear Oligo‐Gd(III) Complexes with Poly (DTPA‐ester) Ligands Derived from Amino Acids
Authors: Yu Kri‐Chao , Wang Xin‐Bing , Ye Chao‐Hui , U U‐Yun , Liu Mai‐Li , Zhuo Ren‐Xi 
Published: September 2010

AbstractSix linear oligo‐DTPA‐ester Gd(III) complexes being used for potential MRI contrast agents were synthesized from amino adds and characterized. Their longitudinal relaxation rates were measured. One of them, die phenylalanine derivative, with high relaxivity, was chosen for the acute toxicity and T1,‐weighted imaging test. The results indicated that there was no obvious toxicity for this new oligomeric Gd(III) complex, and it exhibits the highly enhanced MRI signal intensity and the increasing signal duration in the liver tissue compared to Gd‐DTPA.
Luminescent Property of a Supramolecular Silver(I)‐Thiolate Complex Based on Secondary Ag‐S Interactions and Hydrogen Bonds
Authors: Su Wei‐Ping , Hong Mao‐Chun , Cao Rong , Weng Jia‐Bao , Zhou Zhong‐Yuan , Chan Albert S. C. 
Published: September 2010

AbstractThe supramolecular silver(I)‐thiolate complex [Ag(μ2‐SC4N2H4)2(SCN)]n has been prepared from the reaction of AgSCN and pyrimidine‐2‐thiol in DMF. X‐ray diffraction analysis shows that the supramolecular structure exhibits one‐dimensional chain through the secondary Ag‐S interactions and the chains are further linked by strong hydrogen bonds to form a three dimensional network. The luminescence effect from the silver‐centered state of S→Ag LMCT in solid state is different from that in solution due to the secondary Ag‐S interactions.
Energy resonance and inverse population of the product vibrational states for the reaction F + H2(v = 0) → HF(v′) + H, LCAC‐SW theoretical quantum scattering study
Authors: Cai Zheng‐Ting , Kang Cong‐Min , Feng Da‐Cheng 
Published: September 2010

AbstractLCAC‐SW (linear combination of arrangement channel‐scattering wavefunction) method was used to calculate collinear state‐to‐state reaction probabilities for the reaction F + H2(v = 0) → HF(v′) + H on the 6SEC potential energy surface. The results show that reaction probabilities P02 and P03 [i. e., v′ = 2,3 for reaction F + H2 (v = 0) + HF(v′) + H] are primary, the population of product vibrational states is inverse and the reaction probabilities are oscillatory with collision energies, i.e., there is energy resonance in this reaction, which agrees with a new experiment.
Thermochemical properties of RE (Gly)4 Im (ClO4) 3 2H2O (RE = La, Pr, Nd, Sm, Eu)
Authors: He Shui‐Yang , Liu Xiang‐Rong , Song Di‐Sheng , Hu Rong‐Zu 
Published: September 2010

AbstractThe enthalpies of solution in water for five new light rare earth ternary complexes RE(Gly)4Im(ClO4)3 2H2O (RE = La, Pr, Nd, Sm, Eu; Gly‐glycine; Im‐imidazole) were measured by means of a Calvet microcalorimeter. The empirical formula of enthalpy of solution (ΔsolH), relative apparent molar enthalpy (πLi), relative partial molar enthalpy (Li) and enthalpy of dilution (ΔdllH1,2) were drawn up by the data of enthalpies of solution of these complexes. From three plots of the values of standard enthalpy of solution Δsol Hϕ, πLi, Li) versus the values of ionic radius (r) of the light rare earth elements, the grouping effect of lanthanide was observed, showing that the coordination bond between rare earth ion and ligand possesses a certain extent of the property of a covalent bond. The standard enthalpies of solution in water of similar complexes, Ce(Gly)4Im(ClO4)3.2H2O were estimated according to the plot of ΔsolHϕ, versus r.
Evaluation of the sealed‐tube low‐temperature combustion method for the 13C/12C and 2H/1H ratio determinations of cellulose nitrate
Authors: Tao Fa‐Xiang , Aucour A.‐M. , Sheppard S. M. F. , Liu Cong‐Qiang , Leng Xue‐Tian , Wang Shi‐Lu , Liu Guang‐Shen , Xu Wen‐Bir 
Published: September 2010

AbstractTraditionally‐suggested combustion time of 1 h at 550°C) with the sealed‐tube combustion method for determining the 13C/ 12C ratio of cellulose nitrate or other nitrogen‐containing components could produce large negative deviation up to 1°. Three types of cellulose are used to ascertain possible causes. The presence of nitrous oxide (N2O) formed during combustion is most likely responsible for this deviation. Prolongation of the combustion time (at least 5 h at 550°C) and intimate contact between copper oxide and organic matter can greatly improve the analysis precision and effectively reduce this deviation to an acceptable level. Regardless of scattered carbon isotope data, hydrogen isotope data are all reproducible within 2° when this method is coupled with the high temperature uranium reduction method. Thus, care should be taken for determining carbon and nitrogen isotope compositions of nitrogen‐containing substances using the low temperature sealed‐tube combustion method.
Synthesis, characterization of diorganotin (IV) schiff base complexes and their in vitro antitumor activity
Authors: Yin Dong‐Dong , Jiang Yan‐Lan , Shan Lu 
Published: September 2010

AbstractSix novel diorganotin(IV) complexes have been synthesized in good yields by the reaction of R2SnCl2 (R= methyl, phenyl) with the Schiff base derived from salicylaldehyde and substituted thiosemicarbazide. The complexes were characterized by elemental analysis, IR, 1H NMR and MS spectra. The structure of 2f was confirmed by single crystal X‐ray diffraction. The crystal of 2f is triclinic, space group P‐1 with a = 0.84996(12), b = 1.1204(2), c = 1.27597(12) nm, β = 81.908(9)°, V=1.0904(2) nm3, Z = 2, Dc= 1.551 g/cm3. The final discrepancy factors are R = 0.0211 and Rw = 0.0536 for 3710 independent reflections. Tests of antitumor activities in vitro showed that the obtained complexes had relative inhibition interaction to the KB, HCT‐8 and BEL‐7402 tumor cell lines.
Synthesis and characterization of tribenzyltin heteroaromatic carboxylates and crystal structure of tribenzyltin 4‐pyridinecarboxylate
Authors: Yin Han‐Dong , Wang Chuan‐Hua , Wang Yong , Zhu De‐Zhong , Ma Chun‐Lin 
Published: September 2010

AbstractReaction of tribenzyltin chloride with 2‐furan‐, 2‐(2‐furanyl)‐vinyl‐, 2‐(5‐t‐butyl) furan‐, 2‐thiophene‐, 2‐pyridine‐, 3‐pyridine‐, 4‐pyridine‐, 3(1H)‐indole‐, 3(1H)‐indolylmethyl‐or 3‐[3(1H)‐indolyl]propyl‐carboxylate in 1:1 stoichiometry yielded tribenzyltin heteroaromatic carboxylate (PhCH2)3‐SnO2CR. All compounds were characterized by elemental analysis, IR, ′H NMR and MS. The crystal structure of tribenzyltin 4‐pyridinecarboxylate was determined by single crystal X‐ray diffraction. In the crystal of tribenzyltin 4‐pyridinecarboxylate, the tin atoms are five‐coordinated in a trigonal bipyramidal structure with a linear polymer containing Sn–‐O bond with length of 0. 2142(2) nm and Sn–‐N bond with length of 0.2563(4) nm.
Molecular thermodynamic model for associated polymers
Authors: Peng Chang‐Jun , Liu Hong‐Lai , Hu Ying 
Published: September 2010

AbstractA molecular thermodynamic model for homopolymer and copolymer systems with association segments was established by adopting the molecular thermodynamic model for hardsphere‐chain fluid as a reference, a perturbation term contributed by the square‐well potential and a contribution of association terms. The latter considers the multi‐associated‐segments in a chain‐like molecule based on the shield‐sticky model of chemical association. The model can be used to correlate the pVT of melten homopolymer and copolymer. Good agreements with experimental data have been obtained.
Representation of molecular electrostatic potentials of biopolymer by self‐organizing feature map
Authors: Qiao Xue‐Bin , Jiang Bo , Hou Ting‐Jun , Xu Xiao‐Jie 
Published: September 2010

AbstractThe Kohonen self‐organizing map was introduced to map the protein molecular surface features. The protein or polypeptide properties, such as shape and molecular electrostatic potential, can be visualized by self‐organizing map, which was trained by the 3D surface coordinates. Such maps allow the visual comparison of molecular properties between proteins having common topological or chemical features.
A phase separation fluoroimmunoassay of estradiol
Authors: Wang Yong‐Cheng , Zhao Jin‐Fu , Li Yuan‐Zong , Chang Wen‐Bao , Guo Zben‐Quan 
Published: September 2010

AbstractA competitive indirect fluoroimmunoassay of free estradiol (E2) was established based on the thermal sensitivity of hydrogel–‐poly‐N‐isopropylacrylamide. Free estradiol was covalently bound to bovine serum albumin (BSA) to form complete antigen (E2‐BSA), which was in turn labeled by fluorescein isothiocyanate (FTTC) as the fluorescence probe. The anti‐ E2 monoclonal antibody (McAb) was prepared by an in vivo method, and coupled with N‐isopropylacrylamide (NIPA) to make an immune copolymer, poly‐N‐isopropylacylamidemonoclonal antibody (pNIPA‐McAb), for the determination of free E2. The immunoassay method was based on the competitive binding of free E2 and fluoresceinated antigen (E2‐BSA‐FTTC) with limited amount of pNIPA‐McAb. When the immunological reaction was over, precipitation and centrifugal procedures were carried out to separate pNIPA‐McAb‐E2‐BSA‐FTTC from other constituents in solution. The precipitate pNIPA‐McAb‐E2‐BSA‐FTTC was dissolved in solution and then the fluorescence intensity was measured. The calibration curve covered a range of 78–500 ng/mL for free E2. The recoveries were 91.2–107.2%.
Synthesis and biological activity of l‐aminoindan‐l,3‐dicarboxylic acid, a benzo‐analogue of (1S, 3R)‐ACPD
Authors: Ding Ke , Zhang Xin‐Rong , Ma Da‐Wei , Wang Bao‐Min 
Published: September 2010

AbstractAmino acids 1 and 2 were designed and synthesized as the conformationally constrained analogues of (1S, 3R)‐ or (1S, 3S)‐ACPDs, and the selective agonists of mGluRs. The synthesis started from (R)‐phenylglycine using Seebach′s stereocenter self‐regeneration method and intramolecular acylation as key steps. No activity was found when 1 and 2 were tested as either mGluR agonist or antagonist.
Synthesis of (‐)‐herbertenediol and (aR, aS)‐mastigophorenes A via asymmetric intramolecular heck coupling reaction
Authors: Zhang Ai‐Min , Lin Guo‐Qiang 
Published: September 2010

AbstractTotal enantioselective synthesis of the natural (‐)‐Herbertenediol (1) was accomplished in eleven steps with an overall yield of 15% starting from the 2‐methoxy‐4‐methyl‐phenol. The total synthesis features asymmetric intramolecular Heck reaction and Wolff‐Kishner‐Huang reduction. (aR, aS)‐Mastigophorenes A was also synthesized through the oxidative coupling reaction.
A practical approach to the synthesis of insect antifeedant tonghaosu analogs
Authors: Fan Jun‐Fa , Zhang Yu‐Feng , Wu Yu‐Lin , Wu Yi‐Kang 
Published: September 2010

AbstractTonghaosu and its analogs are a class of structurally interesting spiroketal enol‐ether compounds. A practical route to furandiol, a key intermediate for their syntheses, was developed. Using Friedel‐Crafts benzoylation of 3‐(2‐fury I) propyl acetate, a diarylketone was obtained in high yield, which was further transformed into corresponding furandiol by reduction with NaBH4 in basic medium with simultaneous ester hydrolysis. The furandiol was then cyclized into the desired spiroketal enol‐ether compound in the presence of CuSO4 5H2O.