bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal conceptual theory: Integrating spirituality, mind, and body through Africana concepts
Authors: Burt Isaac 
Published: June 2024

AbstractOptimal conceptual theory (OCT) is a holistic model espousing a person's reality is simultaneously spiritual and material, encapsulating biological, social, cognitive, and spiritual elements, conceptualized through an Africana worldview. Although created over 31 years ago, very little literature exists examining OCT as a viable counseling theory with clients. The purpose of this article is to correct that trend and provide a brief case example illustrating how to utilize OCT in a counseling setting.
Flavonoid gossypetin protects alveolar bone and limits inflammation in ligature‐induced periodontitis in mice
Authors: Seok Jiwon , Kim Myoung Ok , Kim Sung‐Hyun , Ryu Ka‐Young , Kim Jae‐Young , Lee Heon‐Jin , Kim Yong‐Gun , Lee Youngkyun 
Published: June 2024

AbstractBackgroundBacterial‐induced inflammation instigates the destruction of hard and soft tissues surrounding teeth in periodontitis. In severe cases, the increased number and activity of osteoclasts induces the resorption of alveolar bones, ultimately leading to tooth loss. Because of their diverse chemical structures and bioactivities, natural compounds are often suggested to treat a wide variety of diseases, including inflammatory disorders.MethodsIn the present study, we demonstrated an inhibitory effect of gossypetin, a hexahydroxy flavone, on osteoclast differentiation and bone resorption using in vitro culture of osteoclasts from mouse bone marrow macrophage (BMM) precursors and in vivo model of ligature‐induced periodontitis in mice.ResultsGossypetin significantly reduced the differentiation of osteoclasts from mouse BMM precursors in the presence of the receptor activator of nuclear factor κB ligand (RANKL). In vitro, gossypetin inhibited critical signaling events downstream of RANKL including the auto‐amplification of nuclear factor of activated T‐cells, cytoplasmic 1, Ca2+ oscillations, and the generation of reactive oxygen species. In a mouse ligature‐induced periodontitis model, the administration of gossypetin significantly reduced osteoclastogenesis and alveolar bone resorption. Furthermore, gossypetin prevented the ligature‐induced increase in macrophages and T cells and reduced the production of tumor necrosis factor‐α and interleukin‐6.ConclusionTaken together, these results show anti‐osteoclastogenic and anti‐inflammatory effects of gossypetin, suggesting the potential use of this natural compound in periodontitis.
A new method for quantification of tomatine‐enriched extracts
Authors: Faria‐Silva Catarina , Eleutério Carla V. , Simões Pedro , Carvalheiro Manuela , Simões Sandra 
Published: June 2024

AbstractBACKGROUNDGreen tomato extracts, an agro‐food industry waste, are rich in the glycoalkaloid tomatine, which presents activity against several diseases. High‐performance liquid chromatography (HPLC) with ultraviolet (UV) detection is one of the most used techniques for quantification of bioactive compounds. The aim of this study was to optimize and validate a selective HPLC method with diode array detector (DAD) for the quantitative analysis of tomatine extracted from green tomatoes by subcritical water.RESULTSChromatographic runs were performed on a InertSustain Phenyl (250 mm × 4.6 mm, 5 μm) analytical column, at a wavelength of 205 nm. A concentration range of 50–580 μg mL−1 was used. The validation process was performed considering the linearity, precision, trueness, limit of detection (LOD) and limit of quantitation (LOQ) of the method. The selected mobile phase composed of acetonitrile and a solution of 20 mmol L−1 potassium dihydrogen phosphate (KH2PO4) pH 3, resulted in suitable retention times and a standard calibration curve with adequate linearity (R2 = 0.9999). The method trueness was evaluated by the recovery assay, obtaining a mean recovery of 105% and the precisions were 1.4% and 0.9% (percentage relative standard deviation, RSD%) for the tomatine standard and extract samples, respectively. The inter‐day variability was 2.7–9.0% (RSD%) for the standards and 6.9% (RSD%) for extract. The LOD and the LOQ of the method were determined at 8.0 and 24.1 μg mL−1, respectively.CONCLUSIONThe herein described method was successfully used for the quantification of tomatine in a tomato‐derived extract. Furthermore, the method constitutes a simple and rapid analytical approach able to be used as a routine protocol. © 2024 Society of Chemical Industry.
Arthroscopic anterior deltoid plication with bone anchor is an effective procedure to control residual talar anterior translation after lateral ligament repair
Authors: Vega Jordi , Malagelada Francesc , Guelfi Matteo , Dalmau‐Pastor Miki 
Published: June 2024

AbstractPurposeResidual symptoms can be observed after ankle lateral ligament repairs commonly due to hyperlaxity, severe ankle instability or a failed stabilization. In order to increase joint stability, ligament or capsular‐ligament plication has been used in other joints. Given that the anterior portion of the deltoid is a stabilizer against anterior talar translation, it could be used as an augmentation to restrict anterior talar translation. The aim of this study was to describe an arthroscopic anterior deltoid plication with a bony anchor as an augmentation to the lateral stabilization. The results in a series of eight patients were presented.MethodsEight patients (seven males, median age 31 [range, 22–43] years) presented residual instability after arthroscopic all inside lateral collateral ligament repair. Arthroscopic anterior deltoid ligament plication was performed in these patients. Median follow‐up was 22 (range, 15–27) months. Using an automatic suture passer and a knotless anchor, the anterior deltoid was arthroscopically plicated to the anterior aspect of the medial malleolus.ResultsDuring the arthroscopic procedure, only an isolated detachment of the anterior talofibular ligament was observed without any deltoid open‐book injury in any case. All patients reported subjective improvement in their ankle instability after the arthroscopic all‐inside ligament repair and the anterior deltoid plication with a bony anchor. On clinical examination, the anterior drawer test was negative in all patients. The median American Orthopedic Foot and Ankle Society score increased from 68 (range, 64–70) preoperatively to 100 (range, 90–100) at final follow‐up.ConclusionThe arthroscopic anterior deltoid plication is a feasible procedure to augment stability and control anterior talar translation when treating chronic ankle instability in cases of residual excessive talar translation.Level of EvidenceLevel IV.
Long‐term clinical and radiological outcomes after arthroscopic partial meniscectomy on stable knees are better for traumatic tears when compared to degenerative lesions: A systematic review
Authors: Bogas Droy Héloïse , Dardenne Théopol , Djebara Azeddine , Pujol Nicolas 
Published: June 2024

AbstractPurposeAn arthroscopic partial meniscectomy (APM) for degenerative meniscus lesions and traumatic meniscus tears are two distinct entities and their long‐term outcomes are rarely reported. The aim of this review was to compare the long‐term (clinical and radiological) results of APM performed on stable knees for traumatic tears (TT) or degenerative lesions (DL).MethodsPubmed, Scopus and Embase databases were searched to identify relevant studies published between 2010 and 2023 using the keywords ‘meniscectomy’ OR ‘meniscectomies’ OR ‘meniscal resection’. English‐language, Levels I–IV evidence studies reporting either radiographic or clinical outcome measures with a minimum of 6 years' follow‐up after APM were included. Studies including discoid meniscus, open meniscectomy, unstable knee and combination with other procedures were excluded. To rate the quality of evidence, the methodological index for non‐randomized studies was used.ResultsThirty‐two studies were included, with follow‐up periods ranging from 6 to 22 years. Eleven studies dealt with TT with a mean age of 31.5 ± 6.6 years and a mean follow‐up of 11.6 ± 6.9 years. At the last follow‐up, radiographic osteoarthritis (OA) ranged from 36% to 76%, with an average rate of 48 ± 19%; functional scores ranged from 71 to 97, with a mean of 90 ± 4 for the Lysholm score, 86 ± 10 for the International Knee Documentation Committee (IKDC) and 94 ± 16 for the knee injury and osteoarthritis outcome (KOOS). Twenty‐one studies dealt with DL with a mean age of 49.9 ± 7.2 years and a mean follow‐up of 14.9 ± 6.3 years. At the last follow‐up, radiographic OA ranged from 23% to 97%, with an average rate of 77 ± 28%; functional scores ranged from 40 to 87, with a mean of 79 ± 10 for the Lysholm score and 71 ± 16 for the IKDC.ConclusionTen‐year clinical outcomes of APM are better for TTs when compared to DLs. Rates of OA are difficult to compare but lower for TTs.Level of EvidenceLevel IV.
Multi‐objective reliability‐based robust design for a rock tunnel support system using Pareto optimality
Authors: Zhang Zheming , Li Sikan , Zhang Yu , Zhou Yifeng , Ji Jian 
Published: June 2024

AbstractIn the context of rock material and modeling uncertainties, the optimization of rock tunnel support systems is often conducted by selecting the most cost‐effective solution among several feasible options that typically rely on the engineer's experience, potentially leading to overlooking the most optimal design. To improve such a limitation, this paper presents a multi‐objective reliability‐based robust design, considering the cost, safety, and design robustness systematically while maintaining the computational efficiency. In this framework, the uncertainty‐based reliability constrains is performed using the first‐order reliability method (FORM) and an improved Hasofer–Lind–Rackwits–Fiessler recursive algorithm (iHLRF‐x). The design robustness, in terms of sensitivity index (SI), is evaluated using the normalized gradient of the system response to the noise factors, which can be efficiently obtained from the output of FORM analysis. Then, the Pareto front revealing the tradeoff between multiple objectives can be directly generated using the proposed optimization framework. To illustrate the effectiveness of this procedure, a set of the optimal design combinations of the shotcrete thickness and installation position for the exampled rock tunnel are obtained, and new perspectives pertaining the success of the reliability‐based robust designs are provided.
Efficacy of enteral feeding by gastrostomy tube placement in patients with Lennox‐Gastaut syndrome on body weight and days of hospitalization: A retrospective case series
Authors: Lee Sangbo , Ko Ara , Park Sowon , Kim Kyung Won , Ihn Kyong , Ho In Geol , Kim Se Hee , Kim Heung Dong , Lee Joon Soo , Kang Hoon‐Chul 
Published: June 2024

AbstractBackgroundLennox‐Gastaut syndrome (LGS) is a severe form of drug‐resistant epilepsy that begins during childhood and frequently leads to significant neurological impairments. Patients with LGS are likely to receive improper oral nutrition because of issues such as dysphagia and aspiration risk, potentially resulting in long‐term tube feeding and eventual gastrostomy tube placement. Therefore, we investigated the effects of gastrostomy tube placement on nutrition outcomes and frequency of hospitalization in LGS.MethodsWe retrospectively examined 67 patients diagnosed with LGS who had undergone gastrostomy tube placement between January 2005 and August 2022. Comprehensive clinical data and complications arising from the procedure were collected. Patients’ nutrition condition and frequency of hospitalizations were analyzed before and after gastrostomy tube placement.ResultsGastrostomy tube placement was performed for the following reasons: high risk of aspiration (50 out of 67, 74.6%), dysphagia (13 out of 67, 25.4%), persistent nasogastric tube feeding (2 out of 67, 3.0%), and severe malnutrition (2 out of 67, 3.0%). After the procedure, z scores for weight‐for‐age improved significantly, shifting from –3.35 ± 3.57 to –2.54 ± 2.70 over a 2‐year interval (P < 0.001). Additionally, the total days of hospitalization and days of hospitalization due to respiratory symptoms reduced significantly from 41.94 ± 51.76 to 15.27 ± 26.68 (P < 0.001) and from 23.75 ± 36.92 to 10.52 ± 22.98 (P = 0.009), respectively. Among the patients, 50 (74.6%) experienced complications resulting from gastrostomy, with a relatively small proportion of major complications (11 out of 67, 16.4%) and no mortality.ConclusionGastrostomy tube placement is a relatively safe procedure with favorable effects on nutrition status and hospitalization rates in patients with LGS.
Effect of crystalline phase formed by compound flame retardant on the flame retardancy and ceramization of polyethylene composites
Authors: Zhang Xiangbin , Xu Lang , Sun Qing , Zhang Jian , Sheng Jiawei 
Published: June 2024

AbstractCeramic polyolefin composites have the capability to transform into hard ceramics when exposed to fire conditions. During the ceramization process, the formation of new crystalline phase plays a crucial role in enhancing flame‐retardant and ceramifiable properties. Consequently, ceramic polyolefin composites show great potential for the applications in fire‐resistant wires and cables. In this article, the incorporation of the compound flame retardant consisting of ammonium polyphosphate/melamine cyanurate/zinc borate (APP/MCA/ZB) was found to enhance the flame retardancy and ceramization of polyethylene/wollastonite fiber/phosphate glass frits (PE/WF/PGF) composites. The results indicated that ceramifiable flame‐retarding PE composites with compound flame retardant exhibited superior flame retardancy compared to pure PE and PE composites with a single flame retardant. Specifically, the limiting oxygen index (LOI) was significantly increased to 26.8%, and the vertical combustion test rating in UL‐94 (test for flammability of plastic materials for parts in devices and appliances) reached V‐0. During the heating process, ZB thermally decomposed to produce 2ZnO ⋅ 3B2O3, which reacted with CaSiO3 to form a silicate glass intermediate phase (CaO ⋅ SiO2 ⋅ 2ZnO ⋅ 3B2O3). APP thermally decomposed to produce (HPO3)n, which reacted with 2ZnO ⋅ 3B2O3 to form a phosphate glass intermediate phase (nP2O5 ⋅ 2ZnO ⋅ 3B2O3). These two glass phases experienced a eutectic reaction with WF, ultimately producing the formation of a new crystalline phase of calcium zinc phosphate (CZP, Ca19Zn2(PO4)14). This newly formed CZP phase made sintered ceramics more compact and had higher flexural strength. The flexural strength of ceramic residues after sintering was 11.68 MPa, meeting the requirements for practical applications.
From Protein to a Bioactive Peptide: Potent IL‐6 Peptide Antagonist Generated by a Novel Method
Authors: Pisarchik Alexander , Gervasi Noreen , Nesti Edmund 
Published: June 2024

ABSTRACTHere, we describe a new technology, designed to accelerate peptide discovery by quick identification and optimization of the residues critical for protein–protein interactions or ligand binding. We called it PepFusion. It is based on ligation of short DNA sequences generated from known ligand‐binding regions. We tested it by selecting peptide antagonists of interleukin‐6 (IL‐6), a key mediator of inflammatory diseases such as rheumatoid arthritis (RA), Crohn's disease, and Castleman disease (CD). The PepFusion library demonstrated superiority over a random library by yielding a peptide with low micromolar affinity for IL‐6, whereas the random library failed. The affinity of the peptide from the PepFusion library was further enhanced by additional rounds of mutagenesis leading to peptide variants with low nanomolar IL‐6 affinity. In addition to generating high‐affinity peptides, our method opens the way to solve the problem of the false positive sequences, which are common with all display technologies.
Oxidative stress in the alveolar lavage fluid of children with Mycoplasma pneumoniae pneumonia
Authors: Wang Mengzhu , Ren Ruijuan , Xu Yuping , Wang Tuanjie , Liang Xiaojun , Li Shujun 
Published: June 2024

AbstractObjectiveTo investigate the correlation between oxidative stress in the bronchoalveolar lavage fluid (BALF) of children with Mycoplasma pneumoniae pneumonia (MPP) and the clinical characteristics of severe MPP (SMPP) and refractory MPP (RMPP).MethodsClinical and BALF‐related data were collected from 83 patients with MPP, of which 29 had SMPP and 54 had general MPP (GMPP); 37 patients were in the RMPP group and 46 in the non‐RMPP group. The levels of malondialdehyde (MDA) and advanced oxidation protein products (AOPP) as well as the activity levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH‐PX) in BALF were detected. Logistic regression analyses were performed on MDA, AOPP, SOD, GSH‐PX, gender, heat peak, neutrophil percentage, C‐reactive protein, lactate dehydrogenase, d‐dimer, lung consolidation, sputum embolus, and pleural effusion.ResultsThe levels of MDA and AOPP in the BALF of the MPP group were significantly higher than those in the control group (p < .05), whereas SOD and GSH‐PX levels were lower than those in the control group (p < .05). The BALF AOPP levels in the RMPP group were higher than those in the non‐RMPP group, and the SOD and GSH‐PX levels in the BALF were lower than those in the non‐RMPP group; the difference was statistically significant (p < .05). The levels of MDA and AOPP in the BALF of children in the SMPP group were higher than those in the GMPP group, and the levels of SOD and GSH‐PX were lower than those in the GMPP group, with statistically significant differences (p < .05). The C‐index of the logistic regression model was 0.960 (95% confidence interval 0.958–0.963), which indicates that the model has good predictive ability.ConclusionAdvanced oxidation protein products may be a marker for predicting the conditions of SMPP and RMPP, and the prediction model can assess the risk of progression in children to RMPP, which is conducive to clinical diagnosis and treatment.
Exposures and coexisting conditions in pediatric nodular tracheobronchitis
Authors: Grant Lauren M. C. , Collins Emily , Zur Karen B. , Bass Rosara , Phinizy Pelton A. , Piccione Joseph 
Published: June 2024

AbstractBackgroundThe aim of our study was to investigate the prevalence of coexisting conditions and exposures in children with nodular tracheobronchitis diagnosed by flexible bronchoscopy.MethodsWe conducted a single‐center retrospective review of 100 children diagnosed with nodular tracheobronchitis by flexible bronchoscopy between 2012 and 2023.ResultsCommon coexisting diagnoses included gastroesophageal reflux disease (GERD, 50%), dysphagia/aspiration (40%), asthma (30%), recurrent croup (30%), tracheostomy dependence (19%) and eosinophilic esophagitis (EOE) (12%). Bronchoalveolar lavage (BAL) demonstrated cellular inflammation with elevated proportions of neutrophils in 63%, and lymphocytes in 24%. Among 88 patients in whom bacterial cultures were performed, 52% were positive, with Moraxella, Haemophilus, Streptococcal and Pseudomonas species predominating. Among 30 patients who underwent viral testing, 57% were positive, with rhinovirus (82%) and adenovirus (29%) predominating. Patients with neutrophilic inflammation were more likely to have a positive respiratory bacterial culture and/or viral polymerase chain reaction (p = 0.003, 0.005). Evaluation of the gastrointestinal tract included 79 patients with a history of esophagogastroduodenoscopy, 45 patients with a videofluoroscopic swallow study (VFSS), and 45 patients with multi‐channel intraluminal impedance and pH testing. The majority of VFSS were abnormal (60%) demonstrating either laryngeal penetration (33%) or intratracheal aspiration (27%). Median pH reflux and impedance proximal reflux indices were 3.8% and 0.5% respectively.ConclusionPotential contributing factors in the pathophysiology of nodular tracheobronchitis include bacterial and viral infections, GERD, dysphagia/aspiration, and EOE. When nodular tracheobronchitis is observed during bronchoscopy, further evaluation to assess for these conditions should be considered.
Numerical simulation and optimized design of a launching system with a novel charge structure
Authors: Chen Zi‐Jun , Ma Hong‐Hao , Xu Qing‐Tao , He Ze , Shen Zhao‐Wu , Wang Lu‐Qing 
Published: June 2024

AbstractIn this paper, a launching system with a novel charge structure was proposed to improve the interior ballistic performance. According to the working characteristics of the novel launching system, a lumped‐parameter model was established. The parameters of the propellant and the interior ballistic characteristics of the launching system were obtained by experiments. According to the experimental results, the accuracy of the lumped‐parameter model was verified by code. The simulated results were in good agreement with the experimental results. Based on the lumped‐parameter model, the propellant parameters, such as the impetus, the burning rate, the web thickness, and the charge mass, were investigated to understand the interior ballistic performances of the launching system. An optimization method was proposed to design the propellant parameters of the launching system. The results show that the optimal scheme can increase the velocity of the projectile by 9.54 %. Compared with the traditional launching method, the velocity of the projectile is increased by 37.09 % while the peak pressure in the barrel has no change.
Research progress and prospects on agglomeration models and simulation methods of aluminum particles in aluminum‐based composite propellants
Authors: Gao Huanhuan , Wang Fang , Liu Hui , Chen Yukun , Liu Jianzhong 
Published: June 2024

AbstractThe agglomeration of aluminum during the combustion of solid propellants considerably impacts engine operation and has been widely studied in recent years. The characteristics of aluminum agglomeration in aluminum‐based composite propellants have been studied via experiments and simulations. In this study, the agglomeration process and the characteristics of agglomerated particles are summarized. Agglomeration models and simulation methods have garnered considerable attention because they are not influenced by experimental conditions, are economical, and have minimal restrictions. Therefore, five agglomeration models and four simulation methods are introduced herein to investigate agglom eration in aluminum‐based composite propellants. By analyzing the advantages and disadvantages of these models and methods, deeper agglomeration mechanisms can be explored and new directions for suppressing agglomeration can be identified to mitigate agglomeration issues. These efforts can support and guide the design of solid rocket propellants and the safe operation of rocket engines.