bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Roles of an Expanding Wind Field and Inertial Stability in Tropical Cyclone Secondary Eyewall Formation
Authors: Rozoff Christopher M. , Nolan David S. , Kossin James P. , Zhang Fuqing , Fang Juan 
Published: April 2012

Abstract
The Weather and Research and Forecasting Model (WRF) is used to simulate secondary eyewall formation (SEF) in a tropical cyclone (TC) on the β plane. The simulated SEF process is accompanied by an outward expansion of kinetic energy and the TC warm core. An absolute angular momentum budget demonstrates that this outward expansion is predominantly a symmetric response to the azimuthal-mean and wavenumber-1 components of the transverse circulation. As the kinetic energy expands outward, the kinetic energy efficiency in which latent heating can be retained as local kinetic energy increases near the developing outer eyewall.
The kinetic energy efficiency associated with SEF is examined further using a symmetric linearized, nonhydrostatic vortex model that is configured as a balanced vortex model. Given the symmetric tangential wind and temperature structure from WRF, which is close to a state of thermal wind balance above the boundary layer, the idealized model provides the transverse circulation associated with the symmetric latent heating and friction prescribed from WRF. In a number of ways, this vortex response matches the azimuthal-mean secondary circulation in WRF. These calculations suggest that sustained azimuthal-mean latent heating outside of the primary eyewall will eventually lead to SEF. Sensitivity experiments with the balanced vortex model show that, for a fixed amount of heating, SEF is facilitated by a broadening TC wind field.
Systematic Model Error: The Impact of Increased Horizontal Resolution versus Improved Stochastic and Deterministic Parameterizations
Authors: Berner J. , Jung T. , Palmer T. N. 
Published: April 2012

AbstractLong-standing systematic model errors in both tropics and extratropics of the ECMWF model run at a horizontal resolution typical for climate models are investigated. Based on the hypothesis that the misrepresentation of unresolved scales contributes to the systematic model error, three model refinements aimed at their representation—fluctuating or deterministically—are investigated.Increasing horizontal resolution to explicitly simulate smaller-scale features, representing subgrid-scale fluctuations by a stochastic parameterization, and improving the deterministic physics parameterizations all lead to a decrease in the systematic bias of the Northern Hemispheric circulation. These refinements reduce the overly zonal flow and improve the model’s ability to capture the frequency of blocking. However, the model refinements differ greatly in their impact in the tropics. While improving the deterministic and introducing stochastic parameterizations reduces the systematic precipitation bias and improves the characteristics of convectively coupled waves and tropical variability in general, increasing horizontal resolution has little impact.The fact that different model refinements can lead to reductions in systematic model error is consistent with the hypothesis that unresolved scales play an important role. At the same time, this degeneracy of the response to different forcings can lead to compensating model errors. Hence, if one takes the view that stochastic parameterization should be an important element of next-generation climate models, if only to provide reliable estimates of model uncertainty, then a fundamental conclusion of this study is that stochasticity should be incorporated within the design of physical process parameterizations and improvements of the dynamical core and not added a posteriori.
A Comparison of Decadal-to-Interdecadal Variability and Trend in Reanalysis Datasets Using Atmospheric Angular Momentum
Authors: Paek Houk , Huang Huei-Ping 
Published: April 2012

Abstract
An intercomparison of the global relative angular momentum MR in five reanalysis datasets, including the Twentieth Century Reanalysis (20CR), is performed for the second half of the twentieth century. The intercomparison forms a stringent test for 20CR because the variability of MR is known to be strongly influenced by the variability of upper-tropospheric zonal wind whereas 20CR assimilated only surface observations. The analysis reveals good agreement for decadal-to-multidecadal variability among all of the datasets, including 20CR, for the second half of the twentieth century. The discrepancies among different datasets are mainly in the slowest component, the long-term trend, of MR. Once the data are detrended, the resulting decadal-to-multidecadal variability shows even better agreement among all of the datasets. This result indicates that 20CR can be reliably used for the analysis of decadal-to-interdecadal variability in the pre-1950 era, provided that the data are properly detrended. As a quick application, it is found that the increase in MR during the 1976/77 climate-shift event remains the sharpest over the entire period from 1871 to 2008 covered by 20CR. The nontrivial difference in the long-term trend between 20CR and the other reanalysis datasets found in this study provides a caution against using 20CR to determine the trend on the centennial time scale that is relevant to climate change. These conclusions are restricted to the quantities that depend strongly on the upper-tropospheric zonal wind, but the approach adopted in this work will be useful for future intercomparisons of the low-frequency behavior of other climate indices in the reanalysis datasets.
Quantifying the Relevance of Cyclones for Precipitation Extremes
Authors: Pfahl Stephan , Wernli Heini 
Published: April 2012

Abstract
Owing to the huge potential impact of precipitation extremes on society, it is important to better understand the mechanisms causing these events, and their variations with respect to a changing climate. In this study, the importance of a particular category of weather systems, namely cyclones, for the occurrence of regional-scale precipitation extremes is quantified globally using the ECMWF Interim reanalysis (ERA-Interim) dataset. Such an event-based climatological approach complements previous case studies, which established the physical relationship between cyclones and heavy precipitation. A high percentage of precipitation extremes is found to be directly related to cyclones. Regional hot spots are identified where this percentage of cyclone-induced precipitation extremes exceeds 80% (e.g., in the Mediterranean region, Newfoundland, near Japan, and over the South China Sea). The results suggest that in these regions changes of heavy precipitation with global warming are specifically sensitive to variations in the dynamical forcing, for example, related to shifts of the storm tracks. Furthermore, properties of cyclones causing extreme precipitation are investigated. In the exit regions of the Northern Hemisphere storm tracks, these cyclones are on average slightly more intense than low pressure systems not associated with precipitation extremes, but no differences with respect to minimum core pressure are found in most other parts of the midlatitudes. The fundamental linkage between cyclones and precipitation extremes may thus provide guidance to forecasters involved in flood prediction, but it is unlikely that forecasting rules based on simple cyclone properties can be established.
Association Between Glycosylated Hemoglobin and Intentional Weight Loss in Overweight and Obese Patients With Type 2 Diabetes Mellitus
Authors: Shantha Ghanshyam Palamaner Subash , Kumar Anita Ashok , Kahan Scott , Cheskin Lawrence J. 
Published: April 2012

Purpose The purpose of this study is to assess the relationship between magnitude of weight loss and improvement in percentage A1C (A1C%) among overweight and obese patients with type 2 diabetes mellitus (DM) undergoing weight reduction. Methods Case records of patients enrolled in 2 university-based weight management programs were reviewed. Patients were sampled if they had a diagnosis of DM and had at least 1 documented A1C% reduction from their baseline value. Weight loss treatment was individualized and consisted of a calorie-restricted diet, a behavior modification plan, and a plan for increasing physical activity. Patient weights were measured at bimonthly visits. A1C% was measured every 3 months. Results Seventy-two patients formed the study cohort. Mean baseline body mass index was 35.1 kg/m2, mean age was 52.6 years, and 59% were males. Mean starting A1C% was 8.6. Patients achieved significant mean weight loss (10.7 kg) at study exit. Weight loss of 6.5 kg (4.5% of baseline body weight), 12.2 kg (8.7%), and 15.9 kg (10.3%) was required to reduce A1C% by 0.5, 1, and 1.5, respectively, and it took a mean of 5.6, 8.7, and 10.1 months, respectively, to achieve this. After adjustment for antidiabetic medication intake, for every 10% weight loss, the predicted reduction in A1C% was 0.81. Conclusions Intentional weight loss of 10% can potentially decrease A1C% by 0.81 among patients with type 2 DM. This finding may be clinically useful in encouraging and counseling a patient attempting weight loss.
Otolaryngology Resident In‐Service Examination Scores Predict Passage of the Written Board Examination
Authors: Puscas Liana 
Published: April 2012

ObjectiveThe purpose of this study was to assess the association between the Otolaryngology Training Examination (OTE) and the passage rate of first‐time examinees on the American Board of Otolaryngology (ABOto) Written Qualifying Examination (WQE).Study DesignHistorical cohort study.SettingDe‐identified database containing information on examinees who took the WQE in 2007 to 2011 and the OTE in 2005 to 2011.Subjects and MethodsOne thousand three hundred nine otolaryngology residents took the WQE for the first time in 2007 to 2011 and the OTE in their final and penultimate years of training in 2005 to 2011. Data were analyzed using 1‐way frequencies and table analysis. Logistic regression was used to model the relationship between the pass/fail WQE result and the OTE percentile score in the final and penultimate years of training. Data transformation was used to analyze WQE passage as a function of OTE scores by deciles and quartiles.ResultsThere is a significant relationship between OTE score and passage of the WQE on the first attempt. The probability of passing the WQE on the first attempt is 97% if the resident scores in the upper 3 quartiles of the OTE in the final and penultimate years of training compared with 70% if the examinee scores in the bottom quartile both years.ConclusionResidents who score in the bottom quartile in both their final and penultimate years of training are at significantly higher risk of failing the WQE on the first attempt. Remediation efforts should be focused on these individuals.
A selective cytopheretic inhibitory device for use during cardiopulmonary bypass surgery
Authors: Pino CJ , Lou L , Smith PL , Ding F , Pagani FD , Buffington DA , Humes HD 
Published: April 2012

Background: Systemic inflammatory response syndrome (SIRS) can occur in association with cardiopulmonary bypass (CPB) surgery, resulting in multiple organ dysfunction (MOD). Activated neutrophils have been implicated as major inciting factors in this process. Neutrophil-depleting filters incorporated within the extracorporeal blood circuit during CPB have been developed and evaluated, with inconsistent clinical results. Methods: A novel, biomimetic, selective cytopheretic device (SCD) was tested in vitro within a blood circuit to assess safety and interactions with blood components and further evaluated ex vivo in a bovine model of CPB surgery during ventricular assist device implantation. Results: In vitro blood circuit studies demonstrated that the SCD reduces circulating neutrophils while maintaining low rates of hemolysis compared to current leukocyte-reduction filters. In the bovine CPB model, animals without SCD treatment (No SCD) demonstrated an increase in circulating white blood cell (WBC) and neutrophil counts, steadily increasing throughout CPB. SCD with only systemic heparin anticoagulation (SCD-H) acutely reduced neutrophils for the first 2 hrs of CPB, but followed with a greater than 6-fold increase in neutrophil counts. SCD treatment with regional citrate anticoagulation along the SCD circuit (SCD-C) reduced systemic neutrophil counts throughout 4 hrs of CPB despite lower amounts of eluted cells from the SCD. When analyzed for immature neutrophils, the control and SCD-H showed increasing counts at later time-points, not seen in the SCD-C group, suggesting a more complex mechanism of action than simple leukoreduction. Conclusions: These results suggest that SCD-C therapy may disrupt the systemic leukocyte response during CPB, leading to improved outcomes for CPB-mediated MOD.
Acute toxic effects of fenpyroximate acaricide on Guppy (Poecilia reticulata Peters, 1859)
Authors: Doğan Nesli , Yazıcı Zehra , Şişman Turgay , Aşkın Hakan 
Published: April 2012

Fenpyroximate (FP), an acaricide, is widely used in the prevention of acarids (mites) in fruit plant gardens. In this study, the acute toxic effects of different concentrations of FP were investigated using adult guppy ( Poecilia reticulata Peters, 1859). Guppy adults were exposed to a range of FP concentrations (25, 50, 75, 100, 125, and 150 µg/L) during 48 h. Static method, which is one of the acute toxicity experiments, has been used in this study. According to probit analysis, the 48-h median lethal concentration (LC50) value of FP at 26°C was found to be 72.821 µg/L. Sublethal exposures were predetermined based on 48-h LC50 value. Guppies were exposed to low concentrations (15, 25, and 50 µg/L) of FP for 48 h. Signs of paralysis and behavior deformations were monitored every 12 h in a number of live and dead adults. Low concentrations of FP were also responsible for erratic swimming, loss of equilibrium, and being lethargic. Liver histology revealed several pathological damages including congestion, picnotic nucleus, sinusoidal dilatation, increase in melanomacrophagic centers, and endothelial degeneration. Finally, the toxicity test results provided 48-h LC50 value for FP, and low concentrations of FP can be highly detrimental to guppy adults with clear evidence of behavioral and histologic effects.
An Acute Recovery Unit: the first 18 months
Authors: O’Connor Nick , Mulley Rachael , Grasso Bianca , Lambert Tim , Snars Jeff , Jhita Prehya 
Published: April 2012

Objectives: To describe a new type of acute inpatient unit, the Acute Recovery Unit, at the Concord Centre for Mental Health, Sydney and to report patient characteristics and outcome data for the first 18 months of operation. Methods: The mission, values, principles of care and operation of the Acute Recovery Unit are presented, including the lessons from a review of the first 18 months of operation. The specialist assessment procedure, academic detailing and range of specialist interventions are described. Results: Clinical outcome measures including the Health of the Nation Outcome Scale, Multidimensional Incomplete Recovery – Clinical Global Index and community tenure time post-discharge are presented. Conclusions: The Acute Recovery Unit is an important component of the range of services required at a regional level to respond to those who will develop treatment refractory mental illness.
Suspected acquired hypocobalaminaemic encephalopathy in a cat: resolution of encephalopathic signs and MRI lesions subsequent to cobalamin supplementation
Authors: Simpson Katherine , Battersby Ian , Lowrie Mark 
Published: April 2012

Presenting signs and initial investigations: An 8-year-old female spayed British shorthair cat was presented with a history of waxing and waning neurological signs. Neuroanatomical localisation was consistent with a diffuse forebrain disease. Blood ammonia concentration was increased. Abdominal ultrasonography and a bile acid stimulation test were normal. Magnetic resonance imaging (MRI) revealed hyperintense, bilaterally symmetrical, diffuse lesions on T2-weighted sequences, predominantly, but not exclusively, affecting the grey matter. Serum cobalamin (vitamin B12) concentration was low. Hypocobalaminaemia resulting in a urea cycle abnormality was considered a likely cause of the hyperammonaemia. Treatment: Daily cobalamin injections resulted in a rapid clinical improvement. Eight weeks into treatment neurological examination was unremarkable and there was complete resolution of the MRI lesions. Clinical importance: This is the first reported case of acquired feline hypocobalaminaemia resulting in an encephalopathy. Additionally, this case is unique in describing reversible brain MRI abnormalities in a cobalamin-deficient companion animal.
Nasopharyngeal Disease in Cats
Authors: Reed Nicki , Gunn-Moore Danièlle 
Published: April 2012

Practical relevance: Nasal discharge, sneezing and upper respiratory noise are frequent presenting signs in feline practice. Clinical challenges: The small nasal cavity of the cat can make visualisation of lesions challenging. In addition, investigations may identify only secondary complications of a disease process, rather than the initial aetiological agent. Global importance: Nasopharyngeal disease is a worldwide problem. However, fungal disease shows regional variations in prevalence. Audience: This review, aimed at general practitioners as well as those undertaking more specialist investigations in feline respiratory disease, aims to provide practical guidance on the approach necessary to obtain a diagnosis in cats with nasopharyngeal disease. It should also help to explain why a specific diagnosis may not always be possible. Equipment: While access to endoscopy and computed tomography is advantageous, extensive information can be gained from equipment readily available in all practices. Evidence base: The information presented in this article is based on peer-reviewed publications and the clinical experience of the authors.
From Problem to Success
Authors: Michel Kathryn , Scherk Margie 
Published: April 2012

Practical relevance: Obesity is the most common unhealthy nutritional condition that is recognized in cats. Documented associated health risks include diabetes mellitus, lameness, non-allergic skin disease, feline lower urinary tract disease and idiopathic hepatic lipidosis. Clinical challenges: Simply recommending a diet designed for weight loss fails, in most cases, to result in successful weight loss in the obese or overweight cat. A more in-depth approach that centers on communication and commitment, alongside a program of feeding a predetermined amount of a specific diet plus exercise and enrichment of the cat’s life, offers a chance for a healthy result. Patient group: It has been reported in some developed countries that as much as 40–50% of the feline population may be overweight or obese, with middle-aged cats, male cats, mixed-breed cats and neutered cats being at greatest risk. Audience: This review of what is currently known about the health risks, predisposing factors and treatment of excessive weight gain in cats is aimed at all veterinary health professionals. Evidence base: The information reported in the review is drawn from the current scientific literature as well as from the clinical experience of the authors.
Spry1 as a novel regulator of erythropoiesis, EPO/EPOR target, and suppressor of JAK2
Authors: Sathyanarayana Pradeep , Dev Arvind , Pradeep Anamika , Ufkin Melanie , Licht Jonathan D. , Wojchowski Don M. 
Published: April 2012

AbstractSprouty proteins are established modifiers of receptor tyrosine kinase (RTK) signaling and play important roles in vasculogenesis, bone morphogenesis, and renal uteric branching. Little is understood, however, concerning possible roles for these molecular adaptors during hematopoiesis. Within erythroid lineage, Spry1 was observed to be selectively and highly expressed at CFU-e to erythroblast stages. In analyses of possible functional roles, an Mx1-Cre approach was applied to conditionally delete Spry1. At steady state, Spry1 deletion selectively perturbed erythroid development and led to reticulocytosis plus heightened splenic erythropoiesis. When challenged by hemolysis, Spry1-null mice exhibited worsened anemia and delayed recovery. During short-term marrow transplantation, Spry1-null donor marrow also failed to efficiently rescue the erythron. In each anemia model, however, hyperexpansion of erythroid progenitors was observed. Spry function depends on phosphorylation of a conserved N-terminal PY motif. Through an LC-MS/MS approach, Spry1 was discovered to be regulated via the erythropoietin receptor (EPOR), with marked EPO-induced Spry1-PY53 phosphorylation observed. When EPOR signaling pathways were analyzed within Spry1-deficient erythroid progenitors, hyperactivation of not only Erk1,2 but also Jak2 was observed. Studies implicate Spry1 as a novel regulator of erythropoiesis during anemia, transducer of EPOR signals, and candidate suppressor of Jak2 activity.
Association between polymorphism in the FTO gene and growth and carcass traits in pig crosses
Authors: Dvořáková Věra , Bartenschlager Heinz , Stratil Antonín , Horák Pavel , Stupka Roman , Čítek Jaroslav , Šprysl Michal , Hrdlicová Anna , Geldermann Hermann 
Published: April 2012

Abstract

Background
Independent studies have shown that several single nucleotide polymorphisms (SNP) in the human FTO (fat mass and obesity associated) gene are associated with obesity. SNP have also been identified in the pig FTO gene, among which some are associated with selected fat-deposition traits in F2 crosses and commercial populations. In this study, using both commercial pig populations and an experimental Meishan × Pietrain F2 population, we have investigated the association between one FTO SNP and several growth and carcass traits. Association analyses were performed with the FTO polymorphism either alone or in combination with polymorphisms in flanking loci.

Methods
SNP (FM244720:g.400C>G) in exon 3 of porcine FTO was genotyped by PCR-RFLP and tested for associations with some growth, carcass and fat-related traits. Proportions of genetic variance of four pig chromosome 6 genes (FTO, RYR1, LIPE and TGFB1) on selected traits were evaluated using single- and multi-locus models.

Results
Linkage analysis placed FTO on the p arm of pig chromosome 6, approximately 22 cM from RYR1. In the commercial populations, allele C of the FTO SNP was significantly associated with back fat depth and allele G with muscling traits. In the Meishan × Pietrain F2 pigs, heterozygotes with allele C from the Pietrain sows and allele G from the Meishan boar were more significantly associated with fat-related traits compared to homozygotes with allele G from the Pietrain and allele G from the Meishan breed. In single- and multi-locus models, genes RYR1, TGFB1 and FTO showed high associations. The contribution in genetic variance from the polymorphism in the FTO gene was highest for back fat depth, meat area on the musculus longissimus lumborum et thoracis tissues and metabolite glucose-6-phosphate dehydrogenase.

Conclusions
Our results show that in pig, FTO influences back fat depth in the commercial populations, while in the Meishan × Pietrain F2 pigs with a CG genotype, heterosis occurs for several fat-related traits.