bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aiming at Creativity and Ending up with a Range from Low‐Hanging Fruits to Foolishness: A Reflective Model of Creativity
Authors: Pichot Nicolas , Forthmann Boris , Bonetto Eric , Arciszewski Thomas , Bonnardel Nathalie , Jaubert Sara , Pavani Jean B. 
Published: June 2024

ABSTRACTThe term “creative” is commonly used in everyday language and in academic discourse to discuss the nature of artistic and innovative productions. This usage inherently implies the existence of a variable of creativity that allows different creative works to be compared. The standard definition of creativity asserts that a production must possess both value and novelty in order to be considered truly creative. However, previous psychometric studies aimed at establishing the existence of such a creativity variable based on these two dimensions have produced results that seem to demonstrate their independence or even negative association, based on a weak to negative correlation between value and novelty. These widely replicated empirical results seem to call into question the notion of a single creativity variable associated with productions, leading to a paradoxical use of the term “creative” to describe the object produced. In our study, we aimed to reproduce these results while addressing methodological errors made in previous efforts to establish construct validity. This work led us to test the existence of a common cause for the observed variations in novelty and value. The higher order factor we obtain in our analysis encompasses subtle differences from the conventional creativity axis and interacts negatively with novelty, while correlating positively with value.
Comprehensive gene expression analysis using RNA sequencing between male and female patients with idiopathic carpal tunnel syndrome
Authors: Ogura Yusuke , Miyoshi Hiroaki , Yoshida Shiro , Arakawa Fumiko , Takeuchi Mai , Nakama Kenjiro , Matsuura Mitsuhiro , Takada Hirofumi , Yamanaka Yoshiaki , Hiraoka Koji , Ohshima Koichi 
Published: June 2024

AbstractIdiopathic carpal tunnel syndrome is the most common entrapment neuropathy in hand surgery, and it is characterized by Noninflammatory fibrosis of subsynovial connective tissues. The prevalence and incidence differ between male and female individuals, and the mechanism underlying this difference remains largely unclear. In the present study, we collected subsynovial connective tissues from six male and six female patients diagnosed with idiopathic carpal tunnel syndrome during surgery. We performed a comprehensive gene expression analysis using RNA sequencing to compare the gene expression profiles between male and female patients with idiopathic carpal tunnel syndrome. We identified 26 genes with significantly different expressions between male and female patients, in which POSTN, COL1A1, and COL3A1, which are involved in extracellular matrix organization, and IGF1, an important fibrotic factor, were significantly upregulated in male patients. Immunohistochemistry confirmed the expression of proteins encoded by these genes in tissues, and male patients tended to show increased POSTN expression. Our results indicate that fibrosis of subsynovial connective tissues is induced by different mechanisms in male and female patients, and genes involved in extracellular matrix organization, especially POSTN, might be important factors in male patients. This study provides insight into the pathogenesis of idiopathic carpal syndrome and might contribute to the development of new treatment strategies.
Body composition of adults with chronic intestinal failure receiving home parenteral nutrition: A descriptive cohort study
Authors: Korzilius Julia Wilhelmina , van Asseldonk Monique Johanna Margaretha Dorothea , Wanten Geert Jacobus Antonius , Zweers‐ van Essen Heidi Ester Emmy 
Published: June 2024

AbstractBackgroundChronic intestinal failure (CIF) refers to the long‐lasting reduction of gut function below the minimum necessary to absorb macronutrients, water, and/or electrolytes. Patients with CIF likely develop various forms of malnutrition and dehydration, yet studies that focus primarily on body composition are lacking. Therefore, this study aimed to evaluate the body composition of adult patients with CIF.MethodsThis retrospective descriptive cohort study was performed at the Radboud University Medical Center, a tertiary referral center for CIF treatment in the form of home parenteral nutrition. We collected available bioelectrical impedance analysis (BIA) data from routine care between 2019 and 2023. The primary outcome was body composition, which was evaluated by assessing body mass index (BMI), fat‐free mass index (FFMI), and fat percentage (fat%).ResultsOverall, 147 adult patients with CIF were included with a median (interquartile range) age of 58 (25–68) years; 69% were female. The mean (SD) BMI was 22.1 (4.3) kg/m2, FFMI was 14.2 (1.9) kg/m2 in females and 17.0 (2.0) kg/m2 in males, and fat% was 33.7% (6.8%) in females and 24.6% (6.4%) in males. 63% had an FFMI below references, and 48% had a high fat%.ConclusionThis study found that most adult patients with CIF have an unfavorable body composition characterized by a high fat% and low FFMI despite having a normal mean BMI. These results highlight the necessity for in‐depth nutrition assessment, including BIA measurement. Moreover, future studies should focus on exercise interventions to increase FFMI and improve body composition and function.
Ultrasound Evaluation of Uterine Cavity Changes After Stimulation for In Vitro Fertilization
Authors: Peregrin‐Alvarez Irene , Roman Robert , Schenk Leah , McKenzie Laurie , Woodard Terri , Detti Laura 
Published: June 2024

ObjectivesMock embryo transfer (ET) before in vitro fertilization (IVF) allows for the clinical determination of uterine cavity length (UCL) to optimize embryo placement during clinical ET. Most studies have shown that optimal pregnancy rates occur with clinical ET at a depth of 15 mm from the uterine fundus. In our study, we sought to determine the effect of ovarian stimulation and endometrial preparation on UCL using 2D transabdominal ultrasound.MethodsWe performed a retrospective cohort study comparing documented 2D transabdominal ultrasound measurements of UCL at the time of mock ET and clinical ET. Statistical analyses were performed with SPSS v. 26 with paired sample t‐test and significance determined with P < .05.ResultsSeventy patients who underwent 91 IVF‐ET cycles between 2015 and 2018 at our academic center met inclusion criteria. Patient's demographics include a median age of 34 (interquartile range [IQR]: 31, 37), gravida 1 (IQR: 0, 2), parity 0 (IQR: 0, 0), and body mass index 25.87 (IQR: 21.78, 30.01). There was a statistically significant increase in UCL by 11.9 mm after IVF stimulation (P < .001), compared to mock ET. Mean UCL at the time of mock ET was 7.66 cm (±0.98 cm) and at clinical ET was 8.85 cm (±0.98 cm).ConclusionsThe uterine cavity undergoes a significant length change during ovarian stimulation and endometrial preparation. These findings confirm the remarkable uterine plasticity in response to hormonal stimulation even before pregnancy ensues. These changes in UCL should be considered during ultrasound‐guided clinical ET to ensure optimal embryo placement.
Computer Vision Foundation Models in Endoscopy: Proof of Concept in Oropharyngeal Cancer
Authors: Paderno Alberto , Rau Anita , Bedi Nikita , Bossi Paolo , Mercante Giuseppe , Piazza Cesare , Holsinger Floyd Christopher 
Published: June 2024

ObjectivesTo evaluate the performance of vision transformer‐derived image embeddings for distinguishing between normal and neoplastic tissues in the oropharynx and to investigate the potential of computer vision (CV) foundation models in medical imaging.MethodsComputational study using endoscopic frames with a focus on the application of a self‐supervised vision transformer model (DINOv2) for tissue classification. High‐definition endoscopic images were used to extract image patches that were then normalized and processed using the DINOv2 model to obtain embeddings. These embeddings served as input for a standard support vector machine (SVM) to classify the tissues as neoplastic or normal. The model's discriminative performance was validated using an 80–20 train‐validation split.ResultsFrom 38 endoscopic NBI videos, 327 image patches were analyzed. The classification results in the validation cohort demonstrated high accuracy (92%) and precision (89%), with a perfect recall (100%) and an F1‐score of 94%. The receiver operating characteristic (ROC) curve yielded an area under the curve (AUC) of 0.96.ConclusionThe use of large vision model‐derived embeddings effectively differentiated between neoplastic and normal oropharyngeal tissues. This study supports the feasibility of employing CV foundation models like DINOv2 in the endoscopic evaluation of mucosal lesions, potentially augmenting diagnostic precision in Otorhinolaryngology.Level of Evidence4 Laryngoscope, 134:4535–4541, 2024
Quality of Life in Symptomatic Septal Perforation
Authors: Alegre Edo Berta , Rojas‐Lechuga María Jesús , Quer‐Castells Mireia , González‐Sánchez Nesly , Lopez‐Chacon Mauricio , Hopkins Claire , Alobid Isam 
Published: June 2024

ObjectiveThe aim of this study is to investigate the impact of septal perforation (SP) on quality of life (QoL). SP is compared to the general population and patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) using the Sino‐Nasal Outcome Test 22 (SNOT‐22).MethodsProspective single‐center study in a referral Rhinology Unit from January 2014 to March 2023.ResultsA total of 392 patients were included in three groups: controls (n = 141), CRSwNP (n = 118), and SP (n = 133). The mean score of the SNOT‐22 was significantly higher in the CRSwNP group (42.4, SD = 24.4) and SP (46.5, SD = 22) compared to the control group (6.2, SD = 8.4). Scores by either items or domains were significantly higher in the CRSwNP and SP groups compared to the control group. There were no significant differences in the mean SNOT‐22 between the CRSwNP and SP groups (p = 0.26; 95% CI −1.68–9.99). Domain‐specific analysis of overall SNOT‐22 scores revealed that patients with SP experienced higher levels of disturbances in sleep, function, and psychological domains (p ≤ 0.001).ConclusionSP produces a negative impact on QoL similar to CRSwNP. Moreover, sleep, psychological, and function domains are significantly worse in SP. Etiology and area of SP influence nasal and emotion domain, though more studies on SP using SNOT‐22 and specific questionnaires are needed.Level of Evidence3 Laryngoscope, 134:4480–4487, 2024
Evaluation of spatiotemporal variation and impact factors for vegetation net primary productivity in a typical open‐pit mining ecosystem in northwestern China
Authors: Wang Jinyang , Cui Kuankuan , Yang Fei , Li Jun , Zhang Chengye , Du Tianmeng , Zhang Haoran 
Published: June 2024

AbstractThe vegetation net primary productivity (NPP) is a key indicator for evaluating vegetation carbon sequestration. Exploring its spatiotemporal changes and impact factors is essential for coal mining and ecological restoration in open‐pit mining areas. This study utilized the Carnegie‐Ames‐Stanford‐Approach (CASA) model to calculate monthly vegetation NPP in the Xiwan mine area, a typical open‐pit mine in northwestern China. The trend, stability, and persistence analysis were conducted, along with the development of a grading method to examine the vegetation NPP spatiotemporal variation across different land cover types. Statistical grading and correlation analysis were used to explore the relationships between the topographical factors, meteorological factors, human activities, and vegetation NPP. The following results were obtained: (1) The vegetation NPP in the study area exhibited a high stability and anti‐persistent decrease in trend. NPP reached a peak of 143.49 g C/(m2 year) in 2017, but declined to a low of 118.38 g C/(m2 year) in 2021. (2) The vegetation NPP decreases with increasing elevation and slope, and a relatively strong correlation with temperature and precipitation was also observed. (3) The impact intensity of human activities on vegetation NPP exhibited a rising and fluctuating volatile trend. In 2021, the inhibition of vegetation NPP by human activities reached its peak at 166.42 g C/(m2 year), with an impact effect share of 36.9%. This research provides a comprehensive framework for vegetation NPP analysis in open‐pit mining, offering valuable insights for ecological conservation in mining ecosystems.
Effect of Compressive Modulus of Porous PVA Hydrogel Coating on the Preventing Adhesion of Polypropylene Mesh
Authors: Wei Dandan , Huang Yulin , Ren Pengfei , Liang Min , Xu Li , Yang Liuxin , Zhang Tianzhu , Ji Zhenling 
Published: June 2024

AbstractPP mesh is a widely used prosthetic material in hernia repair. However, visceral adhesion is one of the worst complications of this operation. Hence, an anti‐adhesive PP mesh is developed by coating porous polyvinyl alcohol (PVA) hydrogel on PP surface via freezing‐thawing process method. The compressive modulus of porous PVA hydrogel coating is first regulated by the addition of porogen sodium bicarbonate (NaHCO3) at various quality ratios with PVA. As expected, the porous hydrogel coating displayed modulus more closely resembling that of native abdominal wall tissue. In vitro tests demonstrate the modified PP mesh show superior coating stability, excellent hemocompatibility, and good cytocompatibility. In vivo experiments illustrate that PP mesh coated by the PVA4 hydrogel that mimicked the modulus of native abdominal wall could prevent adhesion effectively. Based on this, the rapamycin (RPM) is loaded into the porous PVA4 hydrogel coating to further improve anti‐adhesive property of PP mesh. The Hematoxylin and eosin (H&E) and Masson trichrome (MT) staining results verified that the resulting mesh could alleviate the inflammation response and reduce the deposition of collagen around the implantation zone. The biomimetic mechanical property and anti‐adhesive property of modified PP mesh make it a valuable candidate for application in hernioplasty.
A Shotgun Metagenomics Investigation into Labeling Inaccuracies in Widely Sold Probiotic Supplements in the USA
Authors: Gundogdu Aycan , Karis Gizem , Killpartrick Adam , Ulu‐Kilic Aysegul , Nalbantoglu Ozkan Ufuk 
Published: June 2024

AbstractWhile probiotics are generally considered safe, concerns persist regarding the accuracy of labels on these supplements and their potential contribution to the spread of antibiotic resistance genes. Given that probiotics are predominantly ingested with a view towards obtaining particular health benefits. The objective of this study is to assess the composition of 50 widely available probiotic supplements in the USA using shotgun metagenome sequencing. The study also determines the potential resistome profile, and the functional characteristics of these products. This study finds that 67% of products does not contain any labeling inaccuracies. Antimicrobial Resistance Genes (ARGs) are identified in several products, particularly Bacillus‐based products carrying between 10 and 56 genes. The risk posed by the presence of these ARGs requires further study. Functional analysis reveals differences in metabolic profiles among probiotic supplements, indicating the importance of strain‐level selection for personalized probiotics. This study provides updated and comprehensive analysis to evaluate a snapshot of the USA market. The study demonstrates that label inaccuracies occur on approximately one third of popular dietary supplement products sold in the USA, supporting the need for improved approaches to marketing and quality control. Further, the risk of antibiotic resistance, especially in Bacillus‐based formulations, should be assessed.
Development and verification of an electron Monte Carlo engine for applications in intraoperative radiation therapy
Authors: Rank Luisa , Lysakovski Peter , Major Gerald , Ferrari Alfredo , Tessonnier Thomas , Debus Jürgen , Mairani Andrea 
Published: June 2024

AbstractBackgroundIn preparation of future clinical trials employing the Mobetron electron linear accelerator to deliver FLASH Intraoperative Radiation Therapy (IORT), the development of a Monte Carlo (MC)‐based framework for dose calculation was required.PurposeTo extend and validate the in‐house developed fast MC dose engine MonteRay (MR) for future clinical applications in IORT.MethodsMR is a CPU MC dose calculation engine written in C++ that is capable of simulating therapeutic proton, helium, and carbon ion beams. In this work, development steps are taken to include electrons and photons in MR are presented. To assess MRs accuracy, MR generated simulation results were compared against FLUKA predictions in water, in presence of heterogeneities as well as in an anthropomorphic phantom. Additionally, dosimetric data has been acquired to evaluate MRs accuracy in predicting dose‐distributions generated by the Mobetron accelerator. Runtimes of MR were evaluated against those of the general‐purpose MC code FLUKA on standard benchmark problems.ResultsMR generated dose distributions for electron beams incident on a water phantom match corresponding FLUKA calculated distributions within 2.3% with range values matching within 0.01 mm. In terms of dosimetric validation, differences between MR calculated and measured dose values were below 3% for almost all investigated positions within the water phantom. Gamma passing rate (1%/1 mm) for the scenarios with inhomogeneities and gamma passing rate (3%/2 mm) with the anthropomorphic phantom, were > 99.8% and 99.4%, respectively. The average dose differences between MR (FLUKA) and the measurements was 1.26% (1.09%). Deviations between MR and FLUKA were well within 1.5% for all investigated depths and 0.6% on average. In terms of runtime, MR achieved a speedup against reference FLUKA simulations of about 13 for 10 MeV electrons.ConclusionsValidations against general purpose MC code FLUKA predictions and experimental dosimetric data have proven the validity of the physical models implemented in MR for IORT applications. Extending the work presented here, MR will be interfaced with external biophysical models to allow accurate FLASH biological dose predictions in IORT.
A strategy for estimating radiation dose to the blood in outpatient settings in differentiated thyroid cancer therapy with 131I‐NaI
Authors: Contardi Marina Alejandra , Namías Mauro , Cragnolino Guido , Arroñada Guillermo Damián , Cragnolino Daniel Eduardo 
Published: June 2024

AbstractBackgroundAlthough standard operational procedures for pre‐therapeutic dosimetry already exist for the determination of the maximum safe activity to treat differentiated thyroid cancer patients, empiric activity administration of 131I is still the most frequent way of treatment. In this way, the absorbed dose to the blood/bone marrow remains unknown.PurposeIn this work, we present a strategy to estimate radiation dose to the blood in an outpatient setting.MethodsA mobile application was developed, which together with an off‐the‐shelf compact semiconductor radiation detector allows the determination of whole‐body time‐integrated activity coefficients. The methodology was tested in a cohort of 79 differentiated cancer patients who received therapeutic 131I activities. Post‐therapeutic whole‐body time‐integrated activity coefficients were compared against pre‐therapeutic estimates in a subset of 13 patients.ResultsThe 95% limits of agreement between pre whole‐body and post whole‐body time integrated activity coefficients were [‐14.4; 6.6] h when considering outliers and [‐6.2; 3.6] h without outliers. A high dispersion in blood dose coefficients was found, with a four‐fold difference between the highest and lower values. Blood doses were significantly higher for patients treated with dosimetrically guided activities than for empirical activities (median dose = 118 vs. 49 cGy, respectively). Blood dose coefficients were significantly lower for patients prepared with recombinant human thyroid stimulating hormone (rhTSH) than for patients prepared with thyroid hormone withdrawal. A low correlation between blood dose and administered activity was found in empirically treated patients (R2 = 0.26).ConclusionsWe successfully implemented a post‐therapeutic internal dosimetry methodology for differentiated thyroid cancer therapy with 131I, which allows to estimate dose to the blood from outpatient measurements with mobile devices. The proposed methodology avoids the need of daily visits to the nuclear medicine department, thus reducing the burden for the patient and for the staff.
Rhabdomyosarcoma targeting with tuned porous silicon nanoparticles
Authors: Dominguez‐Gil Sofia , Sala Rita , Morel Victoria Judith , Nguyen Christophe , Cheikh Khaled El , Morère Alain , Durand Jean‐Olivier , Rössler Jochen , Bernasconi Michele , Cunin Frédérique , Gary‐Bobo Magali 
Published: June 2024

AbstractWe describe porous silicon nanoparticles (pSiNP) chemically functionalized with an analog of mannose 6‐phosphate (AMFA) and a porphyrin derivative to target aggressive pediatric Rhabdomyosarcoma (RMS) tumor cells. Our findings demonstrate that the pSiNP@AMFA@porphyrin nanosystems are efficiently internalized by RMS cells, which overexpress mannose 6‐phosphate receptors, and induce cytotoxicity and phototoxicity when exposed to two‐photon excitation light. These results provide an interesting potential for targeting and treating RMS pediatric tumors.
Psychometric validation of the Persian version of the ethical awareness scale for nurses working in Iranian intensive care units
Authors: Kolagari Shohreh , Moradi Reza , Milliken Aimee , Khoddam Homeira 
Published: June 2024

AbstractAimThe purpose of this study was to translate and validate the ethical awareness scale for nurses working in Iranian intensive care units.DesignA cross‐sectional psychometric study.MethodsThe study was conducted in Oct 2020 to Sep 2021, involving the participation of 200 ICU nurses. The process included translation of the original version of the ethical awareness scale into Persian, following the World Health Organization guideline, for use in Iran. The translated version was then evaluated for reliability, face validity, content validity ratio, content validity index, convergent validity and construct validity.ResultsThe initial reliability of the scale was established. In qualitative face validity, a few items changed slightly and all items were retained in the quantitative face validity assessment. Based on Lawshe's values, three items were removed from the scale during CVR assessment. All items exhibited acceptable CVI scores. Convergent validity was established with an average variance extracted greater than 0.5. The fit indices, such as CFI = 0.94, GFI = 0.94, RMSEA = 0.01, AGFI = 0.97 and CMIN/DF = 2.99, supported the structural model of the scale. The fit indices for the structural model of the scale were all within acceptable ranges, suggesting that the model fit the data well. Its reliability was confirmed through the test–retest method, with Cronbach's alpha = 0.84 and McDonald's omega coefficient >0.8.ConclusionThe findings of this study indicate the Persian version of the ethical awareness scale for Iran (EAS‐IR) is comparable in content to the original version, demonstrating its validity and reliability for assessing ethical awareness among Iranian nurses in ICUs. The scale can be a valuable resource for measuring ethical awareness in the Iranian healthcare context and may contribute to improving ethical practices and decision‐making in ICU settings.Patient or Public ContributionIn this project, no patient or public contribution was necessary, because it was not applied to our work.