bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Study of Flexible Pavement with Replacement of Bitumen with Melted Tyres& Recycled Aggregates using ANN Technique
Authors: Raina Prateeksha , Gupta Sushindra Kumar 
Published: May 2024

Abstract
Artificial neural network is a data processing mathematical model based on biological neurons. It is a complex structure composed of interconnected neurons that can be used to solve problems and perform tasks. Two essential construction materials in the industry are crumb rubber and destroyed aggregates. For accurate Marshall Stability mix proportioning, this work establishes the usage of ANNtechniques. Five of the most widely used statistical metrics are Pearson correlation coefficient, mean absolute error, and root mean square errors. When compared to other applied models, ANN produces better results. Proposed models should save money in terms of materials, labour, and time while also improving accuracy. The recommended concrete should be more cost-effective and long-lasting.The recommended values such as CC= 0.9484, Mean Absolute error=0.7988, RMSE=0.9478 represents that the result should be more cost-effective and long-lasting.
Groundwater Modelling of Jamwa Ramgarh using Visual MODFlow Flex
Authors: Sharma Yogendra , Gupta Mohit , Ravanan Mr. Arivumani , Mehra Isha , Singh Lavish Kumar , Kumar Monu , Duran Sandeep Kumar , Patel Utkarsh 
Published: May 2024

Abstract
A steady state finite difference model, MODFLOW, is developed to quantify groundwater in Jamwa Ramgarh, Jaipur (Dt) Rajasthan, using Groundwater data from 06 observation wells. ArcGIS was used to generate various shapefiles required as input files in Visual MODFlow Flex. The findings indicate that the calculated contours of groundwater levels closely correspond to the observed contours. The sustainable utilization and management of groundwater resources pose significant challenges for many countries worldwide. In recent years, groundwater modelling has emerged as an effective approach to tackle these challenges. Various modelling software tools are available to simulate groundwater flow, with MODFLOW being widely used to investigate the interactions between surface water and groundwater and to develop models for specific study areas. MODFLOW, a renowned groundwater modelling software, enables researchers and water resource professionals to understand and analyze the complex dynamics of groundwater systems. By utilizing MODFLOW, it becomes possible to assess the interactions between surface water and groundwater, evaluate the impacts of pumping or recharge activities, and make informed decisions regarding the sustainable management of groundwater resources. The utilization of MODFLOW and similar modelling software plays a crucial role in advancing our understanding of groundwater systems and supporting effective groundwater resource management practices.
Influence of square jets in Oxygen transfer in an Open Channel
Authors: Puri Diksha , Sihag Parveen , Thakur M.S 
Published: May 2024

Abstract
Plunging jets are popular for aeration in wastewater treatment plants due to low energy needs. In the present study, square jets were evaluated to determine their effectiveness in providing aeration efficiency by plunging jets in an open channel flow. The study seeks to add to the existing knowledge and provide insight into the performance of single and multiple square plunging jets in wastewater treatment plants. Passing a water sample from the pool through an open channel, via square water jet(s), has shown that variables such as a higher number of jets, and discharge have a significant impact on aeration efficiency (E20). The findings demonstrate that the increase in E20 was found to be 85.22% to 117.6% with Nj=64 over the single jet when discharge was varied from 3.41L/s to 4.75L/s, further affirming the remarkable effectiveness of plunging jets in promoting aeration in open channel flows. Furthermore, it was observed that Fr. No. is the parameter that has the most impact on calculating E20 with correlation of 0.95311.
Polycystic ovary syndrome and endometrial cancer risk: results from a nationwide cohort study
Authors: Frandsen C L B , Gottschau M , Nøhr B , Viuff J H , Maltesen T , Kjær S K , Jensen A , Svendsen P F 
Published: May 2024

Abstract
Most previous studies found an elevated risk of endometrial cancer among women with polycystic ovary syndrome (PCOS). However, these had highly varying methods for ascertainment of PCOS diagnoses and limitations such as few exposed women and short follow-up. In this cohort study, we investigated the association between PCOS and endometrial cancer among women born in Denmark between January 1, 1940, and December 31, 1993 (n = 1 719 121). Data in this study, including PCOS and endometrial cancer diagnoses and covariates, were derived from nationwide registers. We used Cox proportional hazards regression models to calculate hazard ratios (HRs) and 95% CIs. A total of 7862 endometrial cancer cases were identified during 23.7 years of follow-up (IQR, 37.7-61.9). We found an increased risk of endometrial cancer among women with PCOS compared with women without PCOS (HR = 3.02; 95% CI, 2.03-4.49). The risk was increased for premenopausal women (HR = 5.82; 95% CI, 3.64-9.30), whereas no marked association was seen for postmenopausal women. However, for postmenopausal women, results were limited by few cases and young age at the end of follow-up. Mounting evidence of an increased risk for endometrial cancer among women with PCOS reinforces the need for prevention and early detection.
This article is part of a Special Collection on Gynecological Cancers.
The associations of oxaliplatin-induced peripheral neuropathy, sociodemographic characteristics, and clinical characteristics with time to fall in older adults with colorectal cancer
Authors: Hines Robert B , Schoborg Christopher , Sumner Timothy , Thiesfeldt Dana-Leigh , Zhang Shunpu 
Published: May 2024

Abstract
Our purpose was to investigate the associations between falls and oxaliplatin-induced peripheral neuropathy (OIPN), sociodemographic characteristics, and clinical characteristics of older patients with colorectal cancer. The study population consisted of older adults diagnosed with colorectal cancer whose data were obtained from the Surveillance, Epidemiology, and End Results database combined with Medicare claims. We defined OIPN using specific (OIPN 1) and broader (OIPN 2) definitions of OIPN, based on diagnosis codes. Extensions of the Cox regression model to accommodate repeated events were used to obtain overall hazard ratios (HRs) with 95% CIs and the cumulative hazard of fall. The unadjusted risk of fall for colorectal cancer survivors with versus without OIPN 1 at 36 months of follow-up was 19.6% versus 14.3%, respectively. The association of OIPN with time to fall was moderate (for OIPN 1, HR = 1.37; 95% CI, 1.04-1.79) to small (for OIPN 2, HR = 1.24; 95% CI, 1.01-1.53). Memantine, opioids, cannabinoids, prior history of fall, female sex, advanced age and disease stage, chronic liver disease, diabetes, and chronic obstructive pulmonary disease all increased the hazard rate of falling. Incorporating fall prevention in cancer care is essential to minimize morbidity and mortality of this serious event in older survivors of colorectal cancer.
Downregulation of lysine 2-hydroxyisobutyrylation of ErbB3 binding protein 1 at amino acid 210 promotes keratinocyte proliferation via induction of transcription initiation factor IA-mediated rRNA synthesis
Authors: Li Junqin , Wang Ying , Niu Xuping , Xing Jianxiao , Dou Yu , Yao Yuanjun , Liang Yanyang , Wang Zehong , Wang Qiang , Feng Haiyan , Peng Aihong , Guo Yi , Liang Huifang , Guo Yaxin , Li Juan , Hou Ruixia , Cheng Yueai , Qu Tong , Li Xinhua , Yin Guohua , Zhang Kaiming 
Published: May 2024

Abstract

Background
Psoriasis is a prevalent chronic inflammatory dermatosis characterized by the excessive proliferation of keratinocytes (KCs). Lysine 2-hydroxyisobutyrylation (Khib) is a newly identified post-translational modification that regulates various biological processes. Abnormal Khib modification has been associated with the development of autoimmune diseases.

Objectives
To investigate the abnormal Khib modification profile and its pathogenic role in psoriasis.

Methods
Liquid chromatography–tandem mass spectrometry was used to analyse Khib-modified proteins in the epidermis of psoriasis lesions and healthy control skin. Mutated cells and mice with downregulated Khib modification of ErbB3 binding protein 1 (EBP1) at amino acid 210 (EBP1Khib210) were generated, to investigate the functional effects of EBP1Khib210 in psoriasis.

Results
Omics analysis revealed dysregulation of Khib modification in psoriatic lesions, exhibiting a distinct profile compared with controls. We found downregulation of EBP1Khib210 in psoriatic lesions and mice with imiquimod-induced psoriasis. Notably, expression of EBP1Khib210 was upregulated in patients with psoriasis following effective treatment. Decreased EBP1Khib210 enhanced KC viability, proliferation and survival but inhibited apoptosis in vitro. Additionally, Pa2g4K210A mice with downregulated Ebp1Khib210 exhibited more severe psoriatic lesions and enhanced KC proliferation. Moreover, we found that the EBP1K210A mutation increased the interaction between EBP1 and nuclear protein kinase B (Akt), thereby inhibiting mouse double minute 2-mediated transcription initiation factor IA (TIF-IA) ubiquitination and resulting in increased rRNA synthesis and KC proliferation. Downregulation of EBP1Khib210 was attributed to an inflammation-induced increase in histone deacetylase 2 expression.

Conclusions
Downregulation of EBP1Khib210 promoted KC proliferation by modulating Akt signalling and TIF-IA-mediated rRNA synthesis. These insights into Khib modification provide better understanding of the pathogenesis of psoriasis and suggest potential therapeutic targets.
Fibroblasts with high matrix metalloproteinase 2 expression regulate CD8+ T-cell residency and inflammation via CD100 in psoriasis
Authors: Dong Canbin , Lin Jui-Ming , Lu Xiaonian , Zhu Junhao , Lin Lanmei , Xu Jinhua , Du Juan 
Published: May 2024

AbstractBackgroundPsoriasis is a T cell-mediated chronic inflammatory skin condition characterized by the interaction of T cells with various cell types, forming an inflammatory microenvironment that sustains psoriatic inflammation. Homeostasis of these tissue-resident T cells is supported by fibroblasts, the primary structural cells in the dermis. In psoriasis, there is increased expression of matrix metalloproteinase 2 (MMP2), mediating structural alterations in skin tissues and modulating inflammation. Additionally, the CD100–plexin-B2 (PLXNB2) axis is known to enhance psoriasis inflammation via keratinocytes, and CD103 levels are associated with the severity of psoriasis upon relapse.ObjectivesTo elucidate the role of fibroblasts and the MMP2–CD100 axis in modulating psoriasis inflammation.MethodsCD100 expression and function in psoriasis were assessed using immunofluorescence, enzyme-linked immunosorbent assay, single-cell transcriptome sequencing, cellular interaction analyses and quantitative reverse transcriptase polymerase chain reaction. CD8+ T cells from people with psoriasis were isolated using magnetic beads, to investigate the regulatory effect of MMP2 on CD100 expression on their membranes. Single-cell transcriptome sequencing, spatial transcriptome sequencing, mimetic timing analysis, immunofluorescence and flow cytometry were used to determine the origin of MMP2 and its impact on CD103+ CD8+ T cells. The hypotheses were further validated in vivo using MMP2 and CD100 inhibitors.ResultsSoluble CD100 (sCD100) was significantly upregulated in both psoriatic lesions and peripheral blood, amplifying psoriasis inflammation by promoting the production of inflammatory cytokines by keratinocytes, fibroblasts and endothelial cells via the sCD100–PLXNB2 axis. Fibroblasts that highly expressed MMP2 (MMP2hi) exacerbated psoriasis symptoms by facilitating CD100 shedding from CD8+ T-cell membranes. Additionally, it was shown that fibroblasts enhance the upregulation of the CD8+ T-cell residency factor CD103 in co-cultures with CD8+ T cells. Inhibitors targeting MMP2 and CD100 were effective in reducing inflammation in an imiquimod-induced psoriasis model.ConclusionsOur findings underscore the pivotal role of MMP2hi fibroblasts in the amplification and recurrence of inflammatory responses in psoriasis. These fibroblasts augment psoriasis inflammation through the CD100–PLXNB2 axis by facilitating CD100 shedding on CD8+ T-cell membranes and by upregulating CD103, thereby enhancing CD8+ T-cell residency.
Laparoscopic Versus Robotic Revisional Bariatric Surgery
Authors: Burgard M , Iranmanesh P , Toso C , Mönig S , Egger B , Pugin F , Jung M 
Published: May 2024

Abstract

Background
Revisional bariatric surgery (RBS) represents up to 15% of all bariatric procedures. The most performed conversion procedures are Roux-en-Y-Gastric Bypass (RYGB) and Vertical Sleeve Gastrectomy (VSG) after adjustable gastric banding (AGB), VSG or vertical banded gastroplasty (VBG). While the overall complication rate is known to be higher compared to primary surgery, the optimal surgical approach, laparoscopic or robotic, remains controversial.

Aims
We aimed to compare laparoscopic and robotic RBS in terms of peri and post-operative complications, ICU admission, operative time, and the length of hospital stay.

Methods
We conducted a retrospective multi-center case control study of patients who underwent RBS from 2013 to 2023 in two centers. Cases and controls were matched by the index procedure, - AGB or a stapled procedure and the revisional procedure, - RYGB or VSG.

Results
59 revisional procedures were performed (36 and 23 per center). After matching according to index and revisional procedures, 46 patients were included, 23 in the robotic and 23 in the laparoscopic group. There were no statistically significant differences in demographics, BMI, or comorbidities between the groups. The overall peri- and early post-operative complication rate was similar while patients in the laparoscopic group had a higher rate of severe complications and reoperations (13% versus 0%), however, without reaching a statistically significant difference (p = 0,07). The operative time was shorter in the laparoscopic group (161 +/- 55 versus 232 +/- 63 minutes, p &lt; 0,05).

Conclusion
Our retrospective study showed a tendency towards more severe perioperative complications and reoperations in laparoscopic compared to robotic revisional surgery in patients with similar index and conversion procedures. Patients with complex revisional RYGB could benefit from robotic surgery. As the literature provides contrasting results, further studies should be performed to address this question.
Evaluation of Tolerance Towards Ureteral Double-J-Stents in Children: An Unmet Need
Authors: Frech M , Planta D , Vuille-Dit-Bille R , Holland-Cunz S 
Published: May 2024

Abstract

Background
Ureteric double-J-stents (DJS) are commonly applied devices in urology that often cause irritative symptoms in adults, leading to decreased quality of life. Little is known about how they are tolerated by children. Furthermore, standardized patient-centered care for children has not yet been established.

Aims
The aim of this study was to assess the tolerance of children towards DJS by evaluating their irritative symptom rate and to raise awareness of the need for a standardized evaluation method.

Methods
A prospective observational single-center study was conducted over a period of 14 months on children with indwelling DJS. A questionnaire addressing 5 categories (voiding symptoms, general symptoms, social activities and/or sexual health, catheter removal, and medication) was developed for different age groups and employed after stent removal.

Results
Twenty patients requiring DJS with a mean age of 5.8 years (ranging from 3 months to 15 years) were enrolled in the study. During the indwelling time (mean 6 weeks), 65% (n=13) of the patients suffered from irritative symptoms (intermittent pain and/or voiding problems). There was a positive association between age and the reported pain score (Spearman's ρ = 0.54, p = 0.04).

Conclusion
Irritative symptoms caused by DJS were systematically assessed in children for the first time. To guarantee patient-centered care, our study's high rate of irritative symptoms must be accounted for when employing DJS. With the questionnaire, we provide an example of a sensitive tool to evaluate the management of children with DJS and treatment options to reduce stent-related symptoms.
Clinical Presentation and Risk Factors of Acalculous Cholecystitis in Outpatients, a Literature Review and Retrospective Study
Authors: Dogny C , Fournier I , Sgardello S 
Published: May 2024

Abstract

Background
Acute acalculous cholecystitis in healthy patients is relatively understudied. It is usually described in patients within the intensive care unit, where it is associated with high mortality rates reaching 30%-50% in the literature.

Aims
To review patients who have developed AAC in outpatient or non-ICU settings, identify risk factors and clinical presentation, and compare these data with those in the literature.

Methods
We first performed a literature review. We then determined the inclusion criteria: acalculous cholecystitis confirmed by either an ultrasound, or CT scan, at pathology and intraoperatively. We excluded all patients hospitalized within the ICU or who developed AAC because of multiorgan failure or patients without histopathological evidence. We performed a 5-year search in our institution’s database with the terms “cholecystitis” and “acalculous cholecystitis.

Results
23 patients were included in our study based on histopathology. The most frequent co-morbidities were cardiovascular and metabolic syndrome. The most common complaint was abdominal pain, ten patients (50%) presented to the emergency department with an increase of at least two of three biological markers (CRP, bilirubine and leucocytosis). We had no mortality reported at 30 days.

Conclusion
Epidemiologically, our population’s characteristics correspond to those of other studies, with most patients being male. The majority of patients were ASA III suggesting that this disease concerns more polymorbid patients despite a high percentage of healthy patients. Right upper quadrant pain, whether associated with leukocytosis or not, seems to be the main factor leading to further investigation. Abdominal US is considered the diagnostic technique of choice. However, most patients in our study underwent US and CT. We found that acalculous cholecystitis in outpatients, does not have the high mortality rate that was previously attributed to it, but is more frequent in polymorbid patients with cardiovascular risk factors.
Recurrence and Survival after Robotic vs. Laparoscopic Liver Resection in Very-Early to Early Stage (BCLC 0-A) Hepatocellular Carcinoma: A Retrospective Cohort Study with Propensity Score Matching
Authors: Bernardi L , Bernardi L , Balzano E , Roesel R , Vacca P , Senatore A , Garo M L , Majno-Hurst P , Cristaudi A , Ghinolfi D 
Published: May 2024

Abstract

Background
Robotic (RLR) and laparoscopic liver resection (LLR) provide similar short-term outcomes in hepatocellular carcinoma (HCC) of stage BCLC 0-A, but data on recurrence and survival are still lacking in populations with high prevalence of cirrhosis.

Aims
We investigated the outcomes of RLR vs. LLR for HCC in a cohort with high rate of cirrhosis. The primary endpoint was recurrence-free (RFS) and overall survival (OS); incidence, pattern, and treatment of recurrence were the secondary ones.

Methods
RLRs and LLRs for HCC of stage BCLC 0-A from two tertiary centers for liver surgery were retrospectively reviewed. Propensity score matching (PSM) was used to mitigate selection bias. Survival was estimated with Kaplan Meier method with Log rank.

Results
One-hundred-ninety-six patients underwent RLR (n=68) or LLR (n=128) for BCLC 0-A HCC.
After 1:1 PSM, two groups (RLR=68; LLR=68) of patients with similar characteristics, liver function and HCC features were obtained: age (median) 71-year-old, males 73.5%, underlying cirrhosis 91.2% (Child A 96.8%, MELD &lt;9 96%), portal hypertension 22.1%, single-HCC 90.4%.
At a median follow-up of 29.0 months, 2- and 5-year RFS were 78.0 vs. 59.0% and 54.0 vs. 53.0% (p=0.107), while OS was 97.0 vs. 90.0% and 87.0 vs. 90.0% (p=0.951) for RLR vs. LLR respectively. Incidence of recurrence was similar (35.3 vs. 39.7%; p=0.723) and was mostly within the liver (29.4 vs. 30.9%; p=1.000) or within 2 years after hepatectomy (54.2 vs. 81.5%, p=0.116) in RLR vs. LLRs. Curative-intent treatment of recurrences did not differ (liver transplantation 19.6%, redo-resection 15.7%) except for a tendency to more redo-resections of recurrences after RLR (29.2 vs. 3.7%; p=0.062).

Conclusion
Oncologic outcomes of RLR were not inferior to those of LLR in selected HCC patients of stage BCLC 0-A with underlying cirrhosis. Both techniques guaranteed similar salvageability at HCC recurrence in our experience.
Which Surgical Technique for Liver Resection is Favourable in Patients with Colorectal Liver Metastases?
Authors: Zeindler J , Hess G F , von Heesen M , Muenst S , Bolli M , Soysal S D , Kollmar O , Schmitt A M 
Published: May 2024

Abstract

Background
The liver is the most common metastatic site after curative treatment for colorectal cancer (CRC). Around 50% of all patients with CRC will develop colorectal liver metastases (CRLM). Liver resection (LR) represents a curative treatment option. Benefits of anatomic (ALR) versus non-anatomic liver resection (NALR) show a lack of consistent evidence. While ALR seems to be associated with a higher postoperative complication rate, NALR could lead to more recurrences.

Aims
We investigated complication and survival rates of patients with CRLM after both resection types.

Methods
This is a multicentre cohort study using retrospectively and prospectively collected data. All patients undergoing LR for CRLM between 2009 and 2020 from 3 specialised centres in Switzerland and Germany were included. Complication and survival rates after ALR versus NALR were analysed using uni- and multivariate Cox regression models.

Results
624 patients were included. Median follow-up time was 25.49 months. In 292/624 patients (47%) ALR was performed, while 53% underwent NALR. Complications according to the Clavien-Dindo classification have been observed significantly more often in the ALR group (p=0.001). Especially severe complications grade III and IV have been more present after ALR (36/292 vs. 26/332 and 13/292 vs. 11/332, respectively). Both, length of ICU and postoperative hospital stay have been significantly longer in the ALR group (p&lt;0.001 each). The uni- and multivariate models have shown no significant differences in overall survival (OS) and recurrence free survival rates (RFS) between both groups (for OS adjusted HR of 0.84 (95% CI 0.59 - 1.21; p=0.35) and for RFS adjusted HR 0.92 (95% CI 0.69 - 1.22, p=0.56)).

Conclusion
This multicentre prospective study investigating ALR versus NALR for CRLM has shown no significant differences in OS and RFS. However, postoperative complications have been reported significantly more often after ALR. NALR seems to be the better choice for patients with CRLM undergoing LR.