bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Imidazo[2,1‐b]thiazole Carbohydrate Derivatives: Synthesis and Antiviral Activity Against Junin Virus, Agent of Argentine Hemorrhagic Fever.
Authors: Barradas Jose Sebastian , Errea Maria Ines , D'Accorso Norma B. , Soledad Sepulveda Claudia , Damonte Elsa Beatriz 
Published: May 2011

AbstractThe title compounds (III) and (VI) are also available under thermal conditions.
ChemInform Abstract: A New Method for the Construction of the Hydroxylated Tropane Skeleton: Enantioselective Synthesis of (‐)‐Bao Gong Teng A.
Authors: Lin Geng‐Jie , Zheng Xiao , Huang Pei‐Qiang 
Published: May 2011

AbstractThe intramolecular reductive coupling of aldehyde (IV) gives rise to a mixture which contains the undesired diastereomer (V) as main product.
ChemInform Abstract: A Concise Synthesis of the Molecular Framework of Pleuromutilin.
Authors: Liu Junjia , Lotesta Stephen D. , Sorensen Erik J. 
Published: May 2011

AbstractTwo pleuromutilin analogues (VI) and (X) are prepared via a diastereoselective 1,4‐conjugate addition of cyanide (III) to enones and a ring‐closing metathesis as key steps.
ChemInform Abstract: Elaiomycins B and C: Alkylhydrazide Antibiotics from Streptomyces sp. BK 190.
Authors: Helaly Soleiman E. , Pesic Alexander , Fiedler Hans‐Peter , Suessmuth Roderich D. 
Published: May 2011

AbstractThe structures of the novel title compounds are determined by spectroscopic means.
ChemInform Abstract: Why Hybrid Porous Solids Capture Greenhouse Gases?
Authors: Ferey Gerard , Serre Christian , Devic Thomas , Maurin Guillaume , Jobic Herve , Llewellyn Philip L. , De Weireld Guy , Vimont Alexandre , Daturi Marco , Chang Jong‐San 
Published: May 2011

AbstractReview: 78 refs.
Autonomic regulation in fragile X syndrome
Authors: Heilman Keri J. , Harden Emily R. , Zageris Danielle M. , Berry‐Kravis Elizabeth , Porges Stephen W. 
Published: May 2011

AbstractAutonomic reactivity was studied in individuals with fragile X syndrome (FXS), a genetic disorder partially characterized by abnormal social behavior. Relative to age‐matched controls, the FXS group had faster baseline heart rate and lower amplitude respiratory sinus arrhythmia (RSA). In contrast to the typically developing controls, there was a decrease in RSA with age within the FXS group. Moreover, within the FXS group heart rate did not slow with age. The FXS group also responded with an atypical increase in RSA to the social challenge, while the control group reduced RSA. In a subset of the FXS group, the autonomic profile did not change following 2 months and 1 year of lithium treatment. The observed indices of atypical autonomic regulation, consistent with the Polyvagal Theory, may contribute to the deficits in social behavior and social communication observed in FXS. © 2011 Wiley Periodicals, Inc. Dev Psychobiol 53:785–795, 2011.
Synthesis of Deuterated Mevalonolactone Isotopomers
Authors: Dickschat Jeroen S. , Citron Christian A. , Brock Nelson L. , Riclea Ramona , Kuhz Henning 
Published: May 2011

AbstractA synthetic route was developed for the preparation of deuterated mevalonolactones. Using low‐cost deuterated reagents, this route allows for the independent introduction of deuterium labeling into any carbon position or into any combination of positions. Following this approach, the synthesis of [6,6,6‐2H3]mevalonolactone, [4,4,6,6,6‐2H5]mevalonolactone, [5,5‐2H2]mevalonolactone, [5,5,6,6,6‐2H5]mevalonolactone, and [2,2,6,6,6‐2H5]mevalonolactone is described.
Lectin‐based structural glycomics: A practical approach to complex glycans
Authors: Hirabayashi Jun , Kuno Atsushi , Tateno Hiroaki 
Published: May 2011

AbstractGlycans exist in nature in various forms of glycoconjugates, i.e., glycoproteins, glycolipids, and glycosaminoglycans, either in soluble or membrane‐bound forms. One of their prominent properties distinguished from nucleic acids and proteins is “heterogeneity” largely attributed to their inherent features of biosynthesis. In general, various methods based on the physicochemical principles have been taken for their separation and structural determination although all of them require prior liberation of glycans and appropriate labeling. On the other hand, a series of carbohydrate‐binding proteins, or “lectins,” have extensively been used in a more direct manner for cell typing, histochemical staining, and glycoprotein fractionation. Although most procedures conventionally used are useful, unfortunately they lack “throughput” comparable to a performance required for current omics studies. Recently, a novel technique called lectin microarray has attracted increasing attention from not only glycoscientists but also researchers in other fields, because it is straightforward and also informative. The method is innovating in that it enables direct approach to glycoconjugates such as glycoproteins and even cells without liberation of glycans from the core substrate, and therefore can be effectively applied for the sake of differential profiling in various fields. Concept, strategy, and technical advancement of lectin microarray are described. Also, as an introduction to glycomics, the authors explain the motivation to challenge this theme.
Comparative NMR and MS studies on the mechanism of enantioseparation of propranolol with heptakis(2,3‐diacetyl‐6‐sulfo)‐β‐cyclodextrin in capillary electrophoresis with aqueous and non‐aqueous electrolytes
Authors: Lomsadze Ketevan , Salgado Antonio , Calvo Enrique , Antonio López Juan , Chankvetadze Bezhan 
Published: May 2011

AbstractIn our recent studies, the reversal of the enantiomer migration order (EMO) was observed with heptakis (2,3‐dimethyl‐6‐sulfo)‐β‐CD (HDMS‐β‐CD) when aqueous electrolyte was changed with nonaqueous electrolyte in CE. One‐dimensional rotating frame nuclear Overhauser effect spectroscopy experiments prevailed that an inclusion complex was formed between the analyte and the chiral selector in the aqueous buffer, whereas an external complex resulted when a methanolic electrolyte was employed. In the case of the similarly substituted heptakis (2,3‐diacetyl‐6‐sulfo)‐β‐CD (HDAS‐β‐CD), the external complex was observed in the aqueous buffer but an inclusion complex was formed in methanolic electrolyte. In contrast to heptakis (2,3‐dimethyl‐6‐sulfo)‐β‐CD, no reversal of the enantiomer migration order was observed with HDAS‐β‐CD. In the present study, further mechanisms of enantioselective recognition and separation of propranolol enantiomers with HDAS‐β‐CD were investigated by using different techniques of nuclear magnetic resonance spectroscopy and high‐resolution mass spectrometry. To the best of our knowledge, enantioselective nuclear Overhauser effect was observed for the first time in this study.
Top–down‐directed synchrony from medial frontal cortex to nucleus accumbens during reward anticipation
Authors: Cohen Michael X , Bour Lo , Mantione Mariska , Figee Martijn , Vink Matthijs , Tijssen Marina A.J. , Rootselaar Anne‐Fleur van , Munckhof Pepijn van den , Richard Schuurman P. , Denys Damiaan 
Published: May 2011

AbstractThe nucleus accumbens and medial frontal cortex (MFC) are part of a loop involved in modulating behavior according to anticipated rewards. However, the precise temporal landscape of their electrophysiological interactions in humans remains unknown because it is not possible to record neural activity from the nucleus accumbens using noninvasive techniques. We recorded electrophysiological activity simultaneously from the nucleus accumbens and cortex (via surface EEG) in humans who had electrodes implanted as part of deep‐brain‐stimulation treatment for obsessive–compulsive disorder. Patients performed a simple reward motivation task previously shown to activate the ventral striatum. Spectral Granger causality analyses were applied to dissociate “top–down” (cortex → nucleus accumbens)‐ from “bottom–up” (nucleus accumbens → cortex)‐directed synchronization (functional connectivity). “Top–down”‐directed synchrony from cortex to nucleus accumbens was maximal over medial frontal sites and was significantly stronger when rewards were anticipated. These findings provide direct electrophysiological evidence for a role of the MFC in modulating nucleus accumbens reward‐related processing and may be relevant to understanding the mechanisms of deep‐brain stimulation and its beneficial effects on psychiatric conditions. Hum Brain Mapp, 2012. © 2011 Wiley Periodicals, Inc.
Low serum pepsinogen I and pepsinogen I/II ratio and Helicobacter pylori infection are associated with increased risk of gastric cancer: 14‐year follow up result in a rural Chinese community
Authors: Zhang Xianghong , Xue Liying , Xing Lingxiao , Wang Junling , Cui Jinfeng , Mi Jianmin , Xing Xin , Wang Juan , Du Zhanjun , Misumi Junichi , Tian Qingbao , Wang Liqin 
Published: May 2011

AbstractThe correlation between low serum PG level and H. pylori infection with the development of gastric cancer has caused considerable concerns all over the world. Some authors exclaimed that gastric cancer developed only in patients infected with H. pylori, whereas the other had different findings. In this study, 1,501 adult local residents with determined serum PG levels and anti H. pylori IgG status were followed for 14 years for the development of gastric cancer in a rural community with high risk of gastric cancer in Hebei Province, China. The results showed the accumulated gastric cancer incidence in the subjects with abnormal PG level and those with H. pylori infection were all significantly higher than that in the corresponding normal controls (53.9‰ vs. 12.7‰, p < 0.05 and 23.1‰ vs. 5.93‰, p < 0.05). The highest gastric cancer incidence was seen in the subjects with both abnormal serum PG and positive H. pylori (56.0‰), and followed by the subjects with abnormal PG and negative H. pylori (47.6‰) and those with normal serum PG and positive H. pylori (18.4‰). The abnormal serum PG level (OR 3.029) and H. pylori infection (OR 4.345) were all risk factors for the development of gastric cancer. The results suggested that the subjects with abnormal serum PG level and/or positive H. pylori infection in the rural area of China were all high risk population for gastric carcinoma and the subjects with both abnormal serum PG and positive H. pylori infection were at especially high risk for the development of gastric carcinoma.
Effects of α‐tocopherol on the early phase of osteoporotic fracture healing
Authors: Shuid Ahmad Nazrun , Mohamad Sharlina , Muhammad Norliza , Fadzilah Fazalina Mohd , Mokhtar Sabarul Afian , Mohamed Norazlina , Soelaiman Ima Nirwana 
Published: May 2011

AbstractFracture healing is a complex process, which is more complicated if the bone is osteoporotic. One of the vitamin E isomers, α‐tocopherol, has been found to prevent osteoporosis and improve bone fracture healing but its role in the healing of osteoporotic fractures is still unclear. We carried out a study on the effects of α‐tocopherol supplementation on osteoporotic fracture healing using an ovariectomized rat model, whereby we focused on the early phase of fracture healing, that is, the phase with excessive production of free radicals. Twenty‐four female Sprague–Dawley rats were divided into three groups: sham‐operated (SO), ovariectomized–control (OVC), and ovariectomized + α‐tocopherol supplementation (ATF) groups. The right femora of all the rats were fractured at mid‐diaphysis and K‐wires were inserted for internal fixation. After 2 weeks of treatment, the rats were euthanized and the femora were dissected out for measurement of callous volume by CT‐scan and radiological staging of callous formation and fracture healing. The oxidative parameters of the fractured femora were also measured. The results showed that the callous volume and callous staging were not different between the groups. However, the fracture healing stage of the OVC group was lower than the SO group, while α‐tocopherol supplementation in the ATF group had improved the healing until it was comparable to the SO group. The activities of the anti‐oxidatant enzymes, superoxide dismutase, and glutathione peroxidase in the ATF group were found to be significantly higher than in the OVC group. In conclusion, α‐tocopherol improved fracture healing but had no effect on the callous volume and staging. The improvement in fracture healing may be due to the increased activities of the anti‐oxidatant enzymes in the bone during the early phase of fracture healing of osteoporotic bone. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 29:1732–1738, 2011
Development of a new stir bar sorptive extraction coating and its application for the determination of six pesticides in sugarcane juice
Authors: Barletta Juliana Y. , de Lima Gomes Paulo C. F. , dos Santos‐Neto Álvaro J. , Lancas Fernando M. 
Published: May 2011

AbstractIn this article, a novel polydimethylsiloxane/activated carbon (PDMS‐ACB) material is proposed as a new polymeric phase for stir bar sorptive extraction (SBSE). The PDMS‐ACB stir bar, assembled using a simple Teflon®/glass capillary mold, demonstrated remarkable stability and resistance to organic solvents for more than 150 extractions. The SBSE bar has a diameter of 2.36 mm and a length of 2.2 cm and is prepared to contain 92 μL of polymer coating. This new PDMS‐ACB bar was evaluated for its ability to determine the quantity of pesticides in sugarcane juice samples by performing liquid desorption (LD) in 200 μL of ethyl acetate and analyzing the solvent through gas chromatography coupled with mass spectrometry (GC‐MS). A fractional factorial design was used to evaluate the main parameters involved in the extraction procedure. Then, a central composite design with a star configuration was used to optimize the significant extraction parameters. The method used demonstrated a limit of quantification (LOQ) of 0.5–40 μg/L, depending on the analyte detected; the amount of recovery varied from 0.18 to 49.50%, and the intraday precision ranged from 0.072 to 8.40%. The method was used in the analysis of real sugarcane juice samples commercially available in local markets.
Preparation and characterization of silica monolith modified with bovine serum albumin‐gold nanoparticles conjugates and its use as chiral stationary phases for capillary electrochromatography
Authors: Lu Junyu , Ye Fanggui , Zhang Aizhu , Wei Zong , Peng Yan , Zhao Shulin 
Published: May 2011

AbstractThis paper describes the development of silica monolith modified with bovine serum albumin–gold nanoparticles (BSA‐GNPs) conjugates as chiral stationary phases for capillary electrochromatography (CEC). The bare monolithic silica column was prepared by a sol–gel process and has been modified chemically with 3‐mercaptopropyltrimethoxysilane to provide thiol groups, followed by immobilization of gold nanoparticles via the formation of an Au‐S bond and modification with BSA as the chiral selector via the nitrogen lone pair of electrons. It has been demonstrated that the monolithic chiral stationary phases can be used for the enantioseparation of a number of phenylthiocarbamyl amino acids (PTC‐D/L‐AAs) by CEC. Ten pairs of tested amino acids enantiomers were successfully resolved within 18 min under optimized conditions, and the resolution values were in the range of 1.486–2.083. With PTC‐D/L‐tryptophan used as the probe solute, the influences of applied voltage, organic modifier and buffer pH in mobile phase on apparent retention factor, enantioselectivity and resolution factor were also investigated.
Well‐aligned Nano‐fiberous Membranes Based on Three‐pole Electrospinning with Channel Electrode
Authors: Jafari Akbar , Jeon Jin‐Han , Oh Il‐Kwon 
Published: May 2011

AbstractThree‐pole electrospinning devices integrated with a blade‐cage collector were developed to fabricate well‐aligned nano‐fiberous membranes. The proposed three‐pole configuration with a channel electrode can be a powerful tool in aligning nano‐fibers with regular diameter because the generated electric field can be accurately controlled without severe fluctuation in comparison with other methods. The three‐pole electrospinning method is also valid for industrial mass production and accurate diameter control of the aligned nano‐fibers. magnified image
Estimating air humidity from temperature and precipitation measures for modelling applications
Authors: Eccel Emanuele 
Published: May 2011

AbstractUnlike precipitation and temperature, humidity is not widely measured, fostering the development of algorithms that simulate air humidity using other measures. In humid temperate climates, atmospheric water vapour close to the ground often reaches saturation around the time of minimum temperature. This allows models of daily maximum dew‐point temperature to be built from minimum air temperatures. Once the dew‐point temperature has been estimated, hourly values can be interpolated by assuming that water content in the air remains unchanged during the day, relative humidity being the result of the modulation of air temperature on vapour pressure at saturation. This approach requires certain corrections in order to take into account seasonal and local features. The present work investigated and tested the application of algorithms to simulate relative humidity from minimum daily temperatures in 23 meteorological stations in an Italian alpine region. The basic model is corrected by decreasing dew‐point temperature using temperature and precipitation measures, and also requires specific calibration. With respect to errors in the number of hours with high relative humidity, major biases may be generated at some sites. After correction, the number of sites where these techniques yield acceptable results ranges from about a quarter to a half of the total, the lower figure reflecting a stricter acceptance standard in the driest years. The simulation algorithms yield useful results for stations where site‐specific calibration can be carried out, encouraging the use of simulated series from selected sites for climatic, meteorological and phytopathological modelling. Copyright © 2011 Royal Meteorological Society
Memory deficits in patients with pediatric CNS germ cell tumors
Authors: Wilkening Greta N. , Madden Jennifer R. , Barton Valerie N. , Roberts Adetola , Foreman Nicholas K. 
Published: May 2011

AbstractBackgroundGerm cell tumors (GCT) of the central nervous system including germinomas and nongerminomatous germ cell tumors are rare neoplasms most commonly affecting children and adolescents. Many GCT patients seen at The Children's Hospital Denver complain of memory difficulties at the time of presentation, or demonstrate memory difficulties when assessed. Although case studies suggest that memory deficits may be associated with GCT, this is the first study to investigate memory function across a series of pediatric intracranial GCT patients.ProcedureA total of 26 GCT patients were retrospectively examined for diagnosis, imaging results, intelligence quotient, treatment variables, evidence of increased intracranial pressure at diagnosis, and memory function. Patient Full Scale IQ was measured using the Wechsler intelligence scales. Memory was evaluated with the California Verbal Learning Test.ResultsThe incidence of amnesia in GCT patients was 42%. GCT patients with amnesia were significantly older at diagnosis than those who did not develop amnesia. There was no association between hydrocephalus at presentation or having received radiation and the presence of memory deficits. Several cases of amnesia were not associated with involvement of classic memory structures.ConclusionThe high incidence of measurable memory deficits in GCT patients suggests that amnesia may be a significant risk in this patient population. Memory assessment at diagnosis and appropriate follow‐up services may prove beneficial for GCT patients. Pediatr Blood Cancer 2011; 57: 486–491. © 2011 Wiley‐Liss, Inc.
The clinical phenotype of children with Fanconi anemia caused by biallelic FANCD1/BRCA2 mutations
Authors: Myers Kasiani , Davies Stella M. , Harris Richard E. , Spunt Sheri L. , Smolarek Teresa , Zimmerman Sarah , McMasters Richard , Wagner Lars , Mueller Robin , Auerbach Arleen D. , Mehta Parinda A. 
Published: May 2011

AbstractFanconi anemia (FA) is characterized by progressive marrow failure, congenital anomalies, and predisposition to malignancy. Biallelic FANCD1/BRCA2 mutations are the genetic basis of disease in a small proportion of children with FA with earlier onset and increased incidence of leukemia and solid tumors. Patients with FA have increased sensitivity to chemotherapy and radiation, and upon development of a solid tumor, require modification of these therapies. We report clinical and molecular features of three patients with FA associated with FANCD1/BRCA2 mutations, including two novel mutations, and discuss treatment of malignancy and associated side effects in this particularly vulnerable group. Pediatr Blood Cancer 2012; 58: 462–465. © 2011 Wiley Periodicals, Inc.
Methodological and ethical aspects of randomized controlled clinical trials in minors with malignant diseases
Authors: Rothenberger Lillian G. , Henschel Andreas Dirk , Schrey Dominik , Becker Andreas , Boos Joachim 
Published: May 2011

AbstractBackgroundDue to the new European regulations for pediatric medications, future clinical trials will include an increasing number of minors. It is therefore important to reconsider and evaluate recent methodological and ethical aspects of clinical trials in minors.ProcedureThe following questions were investigated: How are randomized controlled clinical trials (RCTs) performed in practice? Do investigators take into consideration biomedical ethical principles, explicated for example by Beauchamp and Childress, when planning and conducting a trial? The study was conducted in a descriptive manner. A systematic, algorithm‐guided search focusing on RCTs in minors with malignant diseases was carried out in PubMed. One‐thousand‐nine‐hundred‐sixty‐two publications from 2001 to 2005 were randomized in sequence. The first 1,000 publications were screened according to a priori defined inclusion criteria. One hundred seventy‐five publications met the criteria and were reviewed using the SIGN methodological checklist (2004), the CONSORT Statement (2001, section Methods, items 3–12) and indicators for ethical aspects. Seventeen publications were checked by two raters.ResultsInformation on randomization and blinding was often equivocal. The publications were mainly rated positive for the criteria of the SIGN checklist, and mostly rated negative for the additional items of the CONSORT Statement. Regarding the ethical principles, only few contributions were found in the publications. Inter‐rater reliability was good.ConclusionsIn the publications analyzed, we found only limited information concerning methods and reflections on ethical principles of the trials. Improvements are thus necessary and possible. We suggest how such trials and their respective publications can be optimized for these aspects. Pediatr Blood Cancer 2011; 57: 599–605. © 2011 Wiley‐Liss, Inc.