bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preoperative dietary restriction reduces hepatic tumor load by reduced E‐selectin‐mediated adhesion in mice
Authors: van Ginhoven Tessa M. , van den Berg Jan Willem , Dik Willem A. , IJzermans Jan N.M. , de Bruin Ron W.F. 
Published: July 2010

AbstractBackgroundInflammatory responses facilitate metastasis by increasing expression of adhesion molecules. Dietary restriction (30% reduction in daily calorie intake) reduces the expression of adhesion molecules and protects against surgically induced inflammation. DR might therefore beneficially interfere with surgery‐induced inflammation and subsequent adhesion of circulating tumor cells.MethodsBALB/c mice were subjected to 2 weeks dietary restriction prior to inoculation with tumor cells. Intra‐splenic injection of 5.0 × 104 C26‐colon carcinoma cells was followed by splenectomy. Hepatic tumor load was scored after 10 days as a percentage (tumor surface/total liver surface) on H&E stained sections. Liver mRNA expression of adhesion molecules was determined and the effect of serum from dietary restriction mice on in vitro tumor growth and adhesion capacity was assessed.ResultsPreoperative dietary restriction significantly reduced mRNA expression levels of E‐selectin (P = 0.0087) and hepatic tumor load (P = 0.036). Dietary restriction serum did not affect in vitro cell growth but reduced in vitro adhesion of C26 cells to endothelial cells (P = 0.0043).ConclusionsPreoperative dietary restriction reduces hepatic tumor load after injection with tumor cells. Reduced adhesion to endothelial cells and reduced mRNA expression of E‐selectin suggest that dietary restriction reduces tumor load by lowering the adhesion of circulating tumor cells to hepatic vascular endothelium. J. Surg. Oncol. 2010;102:348–353. © 2010 Wiley‐Liss, Inc.
LRRK2 variation and Parkinson's disease in African Americans
Authors: Ross Owen A. , Wilhoite Greggory J. , Bacon Justin A. , Soto‐Ortolaza Alexandra , Kachergus Jennifer , Cobb Stephanie A. , Puschmann Andreas , Vilariño‐Güell Carles , Farrer Matthew J. , Graff‐Radford Neill , Meschia James F. , Wszolek Zbigniew K. 
Published: July 2010

AbstractThe global impact of LRRK2 mutations is yet to be realized with a lack of studies in specific ethnic groups, including those of Asian and African descent. Herein, we investigated the frequency of common LRRK2 variants by complete exon sequencing in a series of publicly available African American Parkinson's disease patients. Our study identified three novel synonymous exonic variants and 13 known coding variations; however, there did not appear to be any frequent (>5%) pathogenic mutations. Given the ethnic‐specific LRRK2 variation previously identified in PD further studies in under‐represented populations are warranted. © 2010 Movement Disorder Society.
Thomas de Quincey and his restless legs symptoms as depicted in “Confessions of an English Opium‐Eater”
Authors: Miranda Marcelo , Williams Anne‐Marie , Garcia‐Borreguero Diego 
Published: July 2010

AbstractThomas de Quincey, a British writer of 19th century, suffered insomnia from the age of 17 years. In his famous “Confessions of an English‐Opium Eater” (1822), he described a symptomatology that could concord with restless legs syndrome long before he became addicted to opium. In this report, we analyze his clinical description and the circumstances leading to his opium addiction. © 2010 Movement Disorder Society
Parkinsonism and motor neuron diseases: Twenty‐seven patients with diverse overlap syndromes
Authors: Gilbert Rebecca M. Wolf , Fahn Stanley , Mitsumoto Hiroshi , Rowland Lewis P. 
Published: July 2010

AbstractIt has long been recognized that signs of motor neuron disease (MND) may accompany clinical evidence of parkinsonism in different neurodegenerative conditions. By using the Columbia University Division of Movement Disorders database, we reviewed data from 5,500 cases of parkinsonism and recorded the presence of upper motor neuron (UMN) dysfunction, lower motor neuron (LMN) dysfunction, or both. Among the 27 patients so identified, we counted those with autonomic dysfunction, cerebellar dysfunction, or dementia. Among the 27 cases, seven had UMN signs and LMN signs as well as parkinsonism and were diagnosed with amyotrophic lateral sclerosis (ALS)‐parkinsonism (Brait‐Fahn disease). Three of the seven had dementia that was not deemed to be frontotemporal dementia (FTD). Six other patients had no LMN signs but had UMN signs and parkinsonism and were classified as having primary lateral sclerosis (PLS)‐parkinsonism. Four patients had both UMN and LMN signs with parkinsonism as well as the characteristic dementia of FTD; they were diagnosed with FTD‐parkinsonism‐ALS. Seven patients had MND, parkinsonism, and autonomic or cerebellar dysfunction, a combination compatible with multiple system atrophy (MSA). Three patients had syndromes compatible with hereditary spastic paraplegia (HSP). In sum, we found that MND occurs in association with diverse parkinsonian syndromes; some are heritable, others sporadic and causes are uncertain. Having MND may be a risk factor forparkinsonism. A prospective study may elucidate this possibility. © 2010 Movement Disorder Society.
Extrapyramidal symptoms in substance abusers with and without schizophrenia and in nonabusing patients with schizophrenia
Authors: Zhornitsky Simon , Stip Emmanuel , Pampoulova Tania , Rizkallah Élie , Lipp Olivier , Bentaleb Lahcen Aït , Chiasson Jean‐Pierre , Potvin Stéphane 
Published: July 2010

AbstractExtrapyramidal symptoms (EPS) such as parkinsonism, dystonia, dyskinesia, and akathisia are conditions of impaired motor function, which are associated with chronic antipsychotic treatment in schizophrenia. In addition, EPS is often exacerbated by psychoactive substance (PAS) abuse, which is frequently observed in this population. Few studies, however, have investigated the contribution of PAS abuse on EPS in PAS‐abusers without comorbid psychosis. This study compared the occurrence of EPS in outpatient schizophrenia patients with (DD group; n= 36) and without PAS abuse (SCZ group; n = 41) as well as in nonschizophrenia PAS abusers undergoing detoxification [substance use disorder (SUD) group; n = 38]. Psychiatric symptoms were measured using the Positive and Negative Syndrome Scale and the Calgary Depression Scale for schizophrenia. Extrapyramidal symptoms were evaluated with the Extrapyramidal Symptoms Rating Scale and the Barnes Akathisia Scale. SUD diagnoses were complemented with urine drug screenings. We found that DD patients exhibited significantly more parkinsonism than SCZ patients. Our subanalyses revealed that cocaine and alcohol abuse/dependence was responsible for the increase in parkinsonism in DD patients. Additionally, we found that SUD individuals exhibited significantly more akathisia than SCZ patients. In these latter individuals, subanalyses revealed that alcohol and cannabis abuse/dependence was responsible for the increase in akathisia. Our results suggest that PAS abuse is a contributor to EPS in individuals with and without schizophrenia. © 2010 Movement Disorder Society.
Decision making in restless legs syndrome
Authors: Bayard Sophie , Yu Huan , Langenier Muriel Croisier , Carlander Bertrand , Dauvilliers Yves 
Published: July 2010

AbstractThe dopamine system is implicated in reward‐based decision making with explicit information (decision making under risk) and implicit probabilities (decision making under ambiguity). Although the pathophysiology of restless legs syndrome (RLS) is not yet fully understood, the genetic factors, iron status, and dopaminergic system are thought to play a role. RLS provides an opportunity to test the dopaminergic hypothesis in a drug‐free population and to characterize reward processing using decision‐making paradigms. We investigated impulsivity, impulse control disorders, and decision making in 50 untreated patients with primary RLS compared with 60 sex‐ and age‐matched normal controls using one night of polysomnography recording, a structured psychiatric interview, and questionnaires (RLS Severity Scale, Beck Depression Inventory, and Urgency Premeditation Perseverance Impulsive Behavior Scale). Subjects performed the Iowa Gambling Task to assess decision making under ambiguity and the Game of Dice Task to assess decision making under risk. Patients with RLS showed selective changes in decision making on the Iowa Gambling Task and normal decision making on the Game of Dice Task compared with controls. Patients with RLS had greater depressive symptoms than controls, but no difference was found in impulsivity, impulse control disorders, or addictive behaviors. Clinical and polysomnographic variables were unrelated to decision‐making performance. Results indicate reduced decision‐making performance under ambiguity in drug‐free patients with RLS. From a clinical perspective, when using dopaminergic medication to treat RLS, patients with abnormal baseline behaviors should be closely monitored. © 2010 Movement Disorder Society
The impact of vascular leg disorders on physical activity in methadone‐maintained adults
Authors: Pieper Barbara , Templin Thomas N. , Kirsner Robert S. , Birk Thomas J. 
Published: July 2010

AbstractChronic venous disorders (CVD) and peripheral arterial disease (PAD) may affect diverse physical activity domains. How CVD and PAD and other relevant variables affect physical activity was examined in 569 opioid‐addicted adults. Both CVD and PAD were significantly inversely related to daily walking, sports, and active living. Effects remained significant in the latent variable regression after controlling covariates. Overall activity was very low; most participants walked less than a half mile daily and rarely engaged in sports. Motivation for physical activity was the strongest predictor (β = .55) of daily physical activity. Health‐care professionals promoting physical activity for injection users should consider the vascular health of their legs and motivational variables in addition to general health. © 2010 Wiley Periodicals, Inc. Res Nurs Health 33:426–440, 2010
Psychological distress in different social network members of breast and prostate cancer survivors
Authors: Segrin Chris , Badger Terry A. 
Published: July 2010

AbstractThe purposes of this investigation were to compare psychological distress among cancer survivors' social network members with different relationships with the survivors and to compare their reported levels of distress with population norms. Participants in this investigation included spouses/significant others (n = 153), siblings (n = 11), adult children (n = 25), parents (n = 10), cousins (n = 6), and friends/others (n = 10) of English or Spanish speaking women with breast cancer and English speaking men with prostate cancer. Network members reported on their symptoms of depression, positive and negative affect, anxiety, and relationship satisfaction. The psychological distress among all relationship types was similar. Spouses, and to a lesser extent, adult children were the only groups whose levels of psychological distress were above population norms. Relationship satisfaction was negatively associated with social network members' psychological distress, and female network members had higher levels of depression than male network members due, in part, to higher perceived stress among female network members. These findings highlight the need to consider the potentially deleterious impact of cancer not just on survivors' spouses, but on other social network members as well and to make services available to network members who may play an important role in the survivor's care and adjustment. © 2010 Wiley Periodicals, Inc. Res Nurs Health 33:450–464, 2010
Mucinous carcinoma of the breast is genomically distinct from invasive ductal carcinomas of no special type
Authors: Lacroix‐Triki Magali , Suarez Paula H , MacKay Alan , Lambros Maryou B , Natrajan Rachael , Savage Kay , Geyer Felipe C , Weigelt Britta , Ashworth Alan , Reis‐Filho Jorge S 
Published: July 2010

AbstractMucinous carcinomas are a rare entity accounting for up to 2% of all breast cancers, which have been shown to display a gene expression profile distinct from that of invasive ductal carcinomas of no special type (IDC‐NSTs). Here, we have defined the genomic aberrations that are characteristic of this special type of breast cancer and have investigated whether mucinous carcinomas might constitute a genomic entity distinct from IDC‐NSTs. Thirty‐five pure and 11 mixed mucinous breast carcinomas were assessed by immunohistochemistry using antibodies against oestrogen receptor (ER), progesterone receptor, HER2, Ki67, cyclin D1, cortactin, Bcl‐2, p53, E‐cadherin, basal markers, neuroendocrine markers, and WT1. Fifteen pure mucinous carcinomas and 30 grade‐ and ER‐matched IDC‐NSTs were microdissected and subjected to high‐resolution microarray‐based comparative genomic hybridization (aCGH). In addition, the distinct components of seven mixed mucinous carcinomas were microdissected separately and subjected to aCGH. Pure mucinous carcinomas consistently expressed ER (100%), lacked HER2 expression (97.1%), and showed a relatively low level of genetic instability. Unsupervised hierarchical cluster analysis revealed that pure mucinous carcinomas were homogeneous and preferentially clustered together, separately from IDC‐NSTs. They less frequently harboured gains of 1q and 16p and losses of 16q and 22q than grade‐ and ER‐matched IDC‐NSTs, and no pure mucinous carcinoma displayed concurrent 1q gain and 16q loss, a hallmark genetic feature of low‐grade IDC‐NSTs. Finally, both components of all but one mixed mucinous carcinoma displayed similar patterns of genetic aberrations and preferentially clustered together with pure mucinous carcinomas on unsupervised clustering analysis. Our results demonstrate that mucinous carcinomas are more homogeneous between themselves at the genetic level than IDC‐NSTs. Both components of mixed mucinous tumours are remarkably similar at the molecular level to pure mucinous cancers, suggesting that mixed mucinous carcinomas may be best classified as variants of mucinous cancers rather than of IDC‐NSTs. Copyright © 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Rasch analysis of the Hospital Anxiety and Depression Scale among caregivers of cancer survivors: implications for its use in psycho‐oncology
Authors: Lambert Sylvie , Pallant Julie F. , Girgis Afaf 
Published: July 2010

AbstractObjective: The Hospital Anxiety and Depression Scale (HADS) is often used to screen for cancer caregivers' anxiety and depression, despite few studies examining the tool's psychometric performance within this population. The purpose of this article is to use Rasch analysis to assess the psychometric properties of the HADS in a sample of cancer caregivers.Methods: HADS was administered to 541 caregivers of a population‐based sample of patients diagnosed with one of the eight most incident cancers in Australia. Rasch analysis was conducted using RUMM2020.Results: More than two‐thirds of caregivers were women and most participants were married (95.9%) and caring for their spouse/partner with cancer (89.8%). The HADS‐Anxiety (HADS‐A) subscale showed good fit to the model, with appropriate internal consistency after removal of item 11. There were no disordered thresholds and no differential item functioning (DIF) for sex or age. To achieve satisfactory model fit for the HADS‐Depression (HADS‐D) subscale item 8 was removed due to DIF for sex and item 14 was rescored to resolve disordered thresholds. Analyses supported the unidimensionality of the individual subscales; however, there was no support for the combination of subscales to form a HADS‐Total.Conclusions: The results of Rasch analysis support the use of a modified version of the HADS‐A and HADS‐D among cancer caregivers. Further research is needed to confirm these findings and identify revised clinical cut‐points. Findings reinforce the need for clinicians and researchers to formally test the psychometric properties of the instruments that they intend to use with different samples. Copyright © 2010 John Wiley & Sons, Ltd.
Communication analysis in oncology care. Performance of a combination of a content analysis system and a global scale
Authors: Fagerlind Hanna , Bergström Ida , Lindblad Åsa Kettis , Velikova Galina , Glimelius Bengt , Ring Lena 
Published: July 2010

AbstractObjective: The aim was to assess the feasibility and reliability of Velikova's Content Analysis System (VCAS) and the Medical Interaction Process System (MIPS) global scale for evaluation of communication in oncology care.Methods: Seventy routine physician consultations with gastro‐intestinal (GI) cancer patients were audio‐recorded.Two coders applied VCAS and MIPS global scale to the consultations. VCAS captures aspects of communication like symptoms, side effects, functional issues (e.g. emotional, social, physical), health‐related quality of life and medical decision making. MIPS global scale measures the total impression of the consultation, e.g. patient centredness and psychosocial focus.Results: In total, 61 of 70 consultations were coded. The coding took twice the consultations' actual durations in minutes for VCAS. The time for coding MIPS global scale equalled the consultations length. However, the coder had then listened to the consultation twice before, coding for VCAS. Cohen's kappa for all aspects measured by VCAS varied between 0.20 and 1, mean 0.80. One category (Info on test) had a kappa of 0.20, the other categories were all above 0.60. Weighted Kappa for MIPS global scale varied between 0.25 and 0.73, mean 0.42.Conclusions: VCAS and MIPS global scale is a feasible combination of tools for evaluating patient–physician communication regarding content, medical decision making and global aspects of communication. VCAS showed high reliability. The MIPS global scale showed lower reliability, due to its sensitivity to the individual coders' unique values, common for all global scales. Further development of the combination of content and global instruments would be valuable. Copyright © 2010 John Wiley & Sons, Ltd.
The reciprocal influences of asthma and obesity on lung function testing, ahr, and airway inflammation in prepubertal children
Authors: Consilvio Nicola P. , Di Pillo Sabrina , Verini Marcello , de Giorgis Tommaso , Cingolani Anna , Chiavaroli Valentina , Chiarelli Francesco , Mohn Angelika 
Published: July 2010

AbstractAlthough asthma and obesity are among the major chronic disorders their reciprocal or independent influences on lung function testing, airways hyperresponsiveness (AHR) and bronchial inflammation has not been completely elucidated.In 118 pre‐pubertal Caucasian children anthropometric measurements functional respiratory parameters (flow/volume curves at baseline and after 6‐minute walk test [6MWT]) together with bronchial inflammatory index (FeNO) were assessed. The study population was divided into four groups according to BMI and the presence or absence of asthma: Obese asthmatic (ObA) Normal‐weight asthmatic (NwA), Obese non‐asthmatic (Ob), non‐asthmatic normal‐weight children (Nw).Baseline PEF and MEF75 (%‐expected) were significantly different across the four groups with significantly lower values of MEF75 in ObA and Ob children when compared to Nw children (P = 0.004 and P = 0.0001, respectively) and this independent role of obesity on upper respiratory flows was confirmed by multiple analysis of covariance.After 6 MWT respiratory parameters decreased only in ObA and NwA children and 12 children presented a positive fall in FEV1, in contrast no changes of respiratory function testing were detected in Ob and Nw children, and only 2 Ob children presented a significant fall in FEV1.FeNO analysis demonstrated significantly higher values in ObA and NwA children when compared to Ob (P = 0.008 and P = 0.0002, respectively) and Nw children (P = 0.0001 and P = 0.0003, respectively), although a significant difference was found between Ob and Nw children (P = 0.0004). Multiple analysis of covariance confirmed an independent role of asthma on this parameter.In conclusion while AHR and airway inflammation are clearly associated with an asthmatic status, obesity seems to induce reduction of upper airways flows associated with a certain degree of pro‐inflammatory changes. Pediatr Pulmonol. 2010;45:1103–1110. © 2010 Wiley‐Liss, Inc.
Laminin‐332 cleavage by matriptase alters motility parameters of prostate cancer cells
Authors: Tripathi Manisha , Potdar Alka A. , Yamashita Hironobu , Weidow Brandy , Cummings Peter T. , Kirchhofer Daniel , Quaranta Vito 
Published: July 2010

AbstractBACKGROUNDMatriptase, a type II transmembrane serine protease, has been linked to initiation and promotion of epidermal carcinogenesis in a murine model, suggesting that deregulation of its role in epithelia contributes to transformation. In human prostate cancer, matriptase expression correlates with progression. It is therefore of interest to determine how matriptase may contribute to epithelial neoplastic progression. One approach for studying this is to identify potential matriptase substrates involved in epithelial integrity and/or transformation like the extracellular matrix macromolecule, laminin‐332 (Ln‐332), which is found in the basement membrane of many epithelia, including prostate. Proteolytic processing of Ln‐332 regulates cell motility of both normal and transformed cells, which has implications in cancer progression.METHODSIn vitro cleavage experiments were performed with purified Ln‐332 protein and matriptase. Western blotting, enzyme inhibition assays, and mass spectrometry were used to confirm cleavage events. Matriptase overexpressing LNCaP prostate cancer cells were generated and included in Transwell migration assays and single cell motility assays, along with other prostate cells.RESULTSWe report that matriptase proteolytically cleaves Ln‐332 in the β3 chain. Substrate specificity was confirmed by blocking cleavage with the matriptase inhibitor, Kunitz domain‐1. Transwell migration assays showed that DU145 cell motility was significantly enhanced when plated on matriptase‐cleaved Ln‐332. Similarly, Transwell migration of matriptase‐overexpressing LNCaP cells was significantly increased on Ln‐332 and, as determined by live single‐cell microscopy, two motility parameters of this cell line, speed and directional persistence, were also higher.CONCLUSIONSProteolytic processing of Ln‐332 by matriptase enhances speed and directional persistence of prostate cancer cells. Prostate 71: 184–196, 2011. © 2010 Wiley‐Liss, Inc.
Templated self‐assembly of block copolymers – Toward the rational design of plasmonic nanorods
Authors: Bohley Christian , Yau Man Yan Eric , Erk Christoph , Wang Yong , Wehrspohn Ralf B. , Schlecht Sabine , Steinhart Martin 
Published: July 2010

AbstractShape‐defining hard templates containing arrays of aligned cylindrical nanopores have been exploited as a powerful tool in the synthesis of tubular and solid, rod‐like one‐dimensional (1D) nanostructures consisting of inorganic and polymeric materials. Gaining control over the mesoscopic fine structure in the 1D nanostructures thus obtained has remained challenging. However, it is easy to conceive that their properties largely depend on internal features characterized by mesoscopic length scales. The self‐assembly of block copolymers inside nanopores with hard confining pore walls can be exploited to rationally generate 1D nanostructures with internal self‐assembled mesoscopic fine structures. These self‐assembled mesoscopic fine structures can be converted to mesopores, into which functional inorganic materials can be deposited. Thus, 1D nanostructures that contain replicas of helical mesopores consisting of functional inorganic materials could be obtained. The complex shapes of the inorganic entities might add additional functionalities to those associated with the bulk inorganic material and with the anisotropy of plain 1D nanostructures. In this way, helical structure motifs can be generated that may exhibit specific optical properties, such as circular dichroism, as shown by simulations.