bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of an Effective Double-Moment Cloud Microphysics Scheme with Prognostic Cloud Condensation Nuclei (CCN) for Weather and Climate Models
Authors: Lim Kyo-Sun Sunny , Hong Song-You 
Published: December 2009

Abstract
A new double-moment bulk cloud microphysics scheme, the Weather Research and Forecasting (WRF) Double-Moment 6-class (WDM6) Microphysics scheme, which is based on the WRF Single-Moment 6-class (WSM6) Microphysics scheme, has been developed. In addition to the prediction for the mixing ratios of six water species (water vapor, cloud droplets, cloud ice, snow, rain, and graupel) in the WSM6 scheme, the number concentrations for cloud and rainwater are also predicted in the WDM6 scheme, together with a prognostic variable of cloud condensation nuclei (CCN) number concentration. The new scheme was evaluated on an idealized 2D thunderstorm test bed. Compared to the simulations from the WSM6 scheme, there are greater differences in the droplet concentration between the convective core and stratiform region in WDM6. The reduction of light precipitation and the increase of moderate precipitation accompanying a marked radar bright band near the freezing level from the WDM6 simulation tend to alleviate existing systematic biases in the case of the WSM6 scheme. The strength of this new microphysics scheme is its ability to allow flexibility in variable raindrop size distribution by predicting the number concentrations of clouds and rain, coupled with the explicit CCN distribution, at a reasonable computational cost.
On the Use of an Adaptive, Hybrid-Isentropic Vertical Coordinate in Global Atmospheric Modeling
Authors: Bleck Rainer , Benjamin Stan , Lee Jin , MacDonald Alexander E. 
Published: December 2009

AbstractThis article is one in a series describing the functionality of the Flow-Following, Finite-Volume Icosahedral Model (FIM) developed at NOAA’s Earth System Research Laboratory. Emphasis in this article is on the design of the vertical coordinate—the “flow following” aspect of FIM. The coordinate is terrain-following near the ground and isentropic in the free atmosphere. The spatial transition between the two coordinates is adaptive and is based on the arbitrary Lagrangian–Eulerian (ALE) paradigm. The impact of vertical resolution trade-offs between the present hybrid approach and traditional terrain-following coordinates is demonstrated in a three-part case study.
The Ocean–Land–Atmosphere Model: Optimization and Evaluation of Simulated Radiative Fluxes and Precipitation
Authors: Medvigy David , Walko Robert L. , Otte Martin J. , Avissar Roni 
Published: December 2009

Abstract
This work continues the presentation and evaluation of the Ocean–Land–Atmosphere Model (OLAM), focusing on the model’s ability to represent radiation and precipitation. OLAM is a new, state-of-the-art earth system model, capable of user-specified grid resolution and local mesh refinement. An objective optimization of the microphysics parameterization is carried out. Data products from the Clouds and the Earth’s Radiant Energy System (CERES) and the Global Precipitation Climatology Project (GPCP) are used to construct a maximum likelihood function, and thousands of simulations using different values for key parameters are carried out. Shortwave fluxes are found to be highly sensitive to both the density of cloud droplets and the assumed shape of the cloud droplet diameter distribution function. Because there is considerable uncertainty in which values for these parameters to use in climate models, they are targeted as the tunable parameters of the objective optimization procedure, which identified high-likelihood volumes of parameter space as well as parameter uncertainties and covariances. Once optimized, the model closely matches observed large-scale radiative fluxes and precipitation. The impact of model resolution is also tested. At finer characteristic length scales (CLS), smaller-scale features such as the ITCZ are better resolved. It is also found that the Amazon was much better simulated at 100- than 200-km CLS. Furthermore, a simulation using OLAM’s variable resolution functionality to cover South America with 100-km CLS and the rest of the world with 200-km CLS generates a precipitation pattern in the Amazon similar to the global 100-km CLS run.
Polarimetric and Electrical Characteristics of a Lightning Ring in a Supercell Storm
Authors: Payne Clark D. , Schuur Terry J. , MacGorman Donald R. , Biggerstaff Michael I. , Kuhlman Kristin M. , Rust W. David 
Published: December 2009

Abstract
On 30 May 2004, a supercell storm was sampled by a suite of instrumentation that had been deployed as part of the Thunderstorm Electrification and Lightning Experiment (TELEX). The instrumentation included the Oklahoma Lightning Mapping Array (OK-LMA), the National Severe Storms Laboratory S-band Weather Surveillance Radar-1988 Doppler (WSR-88D) polarimetric radar at Norman, Oklahoma, and two mobile C-band, Shared Mobile Atmospheric Research and Teaching Radars (SMART-R). Combined, datasets collected by these instruments provided a unique opportunity to investigate the possible relationships among the supercell’s kinematic, microphysical, and electrical characteristics. This study focuses on the evolution of a ring of lightning activity that formed near the main updraft at approximately 0012 UTC, matured near 0039 UTC, and collapsed near 0050 UTC. During this time period, an F2-intensity tornado occurred near the lightning-ring region. Lightning density contours computed over 1-km layers are overlaid on polarimetric and dual-Doppler data to assess the low- and midlevel kinematic and microphysical characteristics within the lightning-ring region. Results indicate that the lightning ring begins in the middle and upper levels of the precipitation-cascade region, which is characterized by inferred graupel. The second time period shows that the lightning source densities take on a horizontal u-shaped pattern that is collocated with midlevel differential reflectivity and correlation coefficient rings and with the strong cyclonic vertical vorticity noted in the dual-Doppler data. The final time period shows dissipation of the u-shaped pattern and the polarimetric signatures as well as an increase in the lightning activity at the lower levels associated with the development of the rear-flank downdraft (RFD) and the envelopment of the vertical vorticity maximum by the RFD.
Improvement in the Use of an Operational Constellation of GPS Radio Occultation Receivers in Weather Forecasting
Authors: Cucurull L. 
Published: December 2009

Abstract
As of May 2007, the National Centers for Environmental Prediction (NCEP) implemented a new Global Data Assimilation System. This system incorporated the assimilation of global positioning system (GPS) radio occultation (RO) profiles from the Constellation Observing System for Meteorology, Ionosphere and Climate (COSMIC) mission, which was launched in April 2006. Since then, this new type of observation has been shown to provide additional information on the thermodynamic state of the atmosphere, resulting in a significant increase in the model skill.
Recent updates of the analysis and modeling codes have required a revision of the algorithm that assimilates GPS RO data. In addition, some modifications in the processing of the observations have further enhanced the need for a revisiting of the assimilation code. Better characterizations of the quality control procedures, observation error structure, and forward modeling for the GPS RO observations are described. The updated system significantly improves the data usage, in particular in the tropics. Different sets of the atmospheric refractive indices are also evaluated in this study. The model performance is proven to be quite sensitive to the chosen coefficients and a reevaluation of these constants is recommended within the GPS community.
The new assimilation configuration results in an improvement in the anomaly correlation scores for the Southern Hemisphere extratropics (∼4.5 h for the 500-mb geopotential heights at day 7) and a reduction of the high- and low-level tropical wind errors. Overall, the benefits of using COSMIC on top of all the other observations used in the operational system are still very significant. The loss in model skill when COSMIC is removed from the observing system is remarkable at day 4 (∼8 h) and steadily increases beyond 12 h with the extended forecast range.
On the Ability of Global Ensemble Prediction Systems to Predict Tropical Cyclone Track Probabilities
Authors: Majumdar Sharanya J. , Finocchio Peter M. 
Published: December 2009

Abstract
The ability of ensemble prediction systems to predict the probability that a tropical cyclone will fall within a certain area is evaluated. Ensemble forecasts of up to 5 days issued by the European Centre for Medium-Range Weather Forecasts (ECMWF) and the Met Office (UKMET) were evaluated for the 2008 Atlantic and western North Pacific seasons. In the Atlantic, the ECMWF ensemble mean was comparable in skill to a consensus of deterministic models. Dynamic “probability circles” that contained 67% of the ECMWF ensemble captured the best track in ∼67% of all cases for 24–84-h forecasts, and were slightly underdispersive beyond 96 h. In contrast, the Goerss predicted consensus error (GPCE) was overdispersive. The addition of the UKMET ensemble yielded improvements in the short range and degradations for longer-range forecasts. The ECMWF ensemble performed similarly when the size was reduced from 50 to 20. On average, it produced a lower measure of independence between its members than an ensemble comprising different deterministic models. The 67% circles normally captured the best track during straight-line motion, but less so for sharply turning tracks. In contrast to the Atlantic, the ECMWF ensemble (and GPCE) was unable to capture sufficient verifications within the 67% probability circles in the western North Pacific, in part because of a less skillful ensemble mean (and consensus). Though further evaluations are necessary, the results demonstrate the potential for ensemble prediction systems to enhance probabilistic forecasts, and for The Observing System Research and Predictability Experiment (THORPEX) Interactive Grand Global Ensemble (TIGGE) to be embraced by the operational and research communities.
A Novel Application of the Problem Areas in Diabetes (PAID) Instrument to Improve Glycemic Control and Patient Satisfaction
Authors: Chawla Apoorva , Saha Chandan , Marrero David G. 
Published: December 2009

Purpose The purpose of this study was to use the Problem Areas in Diabetes (PAID) instrument in a novel manner and assess whether providing primary care physicians the results of the questionnaire completed by their patients immediately prior to a clinical encounter would result in improvement in a patient’s glycemic control and/or postencounter satisfaction score. Methods A 6-month longitudinal pilot study, involving 4 general internal medicine physicians and 61 patients in 4 separate offices, was designed. The patient sample was 54% male and 46% female with ages from 41 to 91. The sample included newly diagnosed diabetic patients and those with longstanding disease; as such, the patient population had a range of diabetes-related complications from none to end-stage renal disease. At baseline, 3-month, and 6-month clinic visits, patients completed the PAID questionnaire, and results were provided to the physician prior to the clinical encounter. Satisfaction was measured postencounter. A1C was checked at all 3 visits with the first visit serving as baseline. Results Patients in all 3 groups had improved hemoglobin A1C, reduced perceived problem areas, and increased satisfaction with the quality of care received. These effects were most pronounced after the first visit and for patients with poorer quality of glycemic control at baseline. Conclusions The PAID instrument facilitates a therapeutic dialogue between patient and physician, has the most effect at the initial encounter, and makes the most impact on at-risk patients presenting with poor glycemic control.
Adult Parenteral Nutrition Utilization at a Tertiary Care Hospital
Authors: Kohli‐Seth Roopa , Sinha Rakesh , Wilson Sara , Bassily‐Marcus Adel , Benjamin Ernest 
Published: December 2009

Background:Guidelines from the American Society for Parenteral and Enteral Nutrition promote appropriate use of parenteral nutrition (PN). In addition, involvement of multidisciplinary nutrition support teams (NSTs) has led to a reduction of inappropriate PN administration. This study evaluated the effect of introducing hospital‐wide PN guidelines and a PN review committee on PN prescription behavior of NSTs in the authors’ hospital.Methods:A PN guidelines form with established indications was developed and made available to the NSTs. A PN review committee was formed to assess the appropriateness of PN prescriptions and educate the NSTs if an inappropriate PN prescription was noted. The initial‐phase PN prescriptions were compared with those in a later (established) phase.Results:Of a total of 614 PN prescriptions, 8.1% did not meet the established indications. The initial phase recorded 312 PN prescriptions, and the established phase had 302 prescriptions. The number of inappropriate PN prescriptions decreased significantly from 11.9% in the initial phase to 4.3% in the established phase (P = .001).Conclusion:The incidence of inappropriate PN prescription was low when NSTs were closely involved in patient care. Availability of written guidelines and continuous oversight of NSTs promoted appropriate PN usage.
Evaluation of Glycemic Control Using NPH Insulin Sliding Scale Versus Insulin Aspart Sliding Scale in Continuously Tube‐Fed Patients
Authors: Cook Amber , Burkitt Dora , McDonald Lynn , Sublett Laurie 
Published: December 2009

Background:Hyperglycemia is often a problem in patients who receive continuous enteral nutrition. The purpose of this study was to determine if the use of sliding‐scale neutral protamine Hagedorn (NPH) insulin was more effective than sliding‐scale insulin aspart in controlling blood glucose in continuously tube‐fed patients.Methods:A retrospective, records‐based review comparing sliding‐scale NPH insulin given every 4 or 6 hours with sliding‐scale insulin aspart was performed in patients admitted to 2 community hospitals between April 1, 2006, and September 30, 2007.Results:Mean blood glucose was found to be lower in patients receiving NPH every 4 hours and NPH every 6 hours than in patients receiving insulin aspart (P < .001). No statistically significant differences in mean blood glucose values (P = .41) were observed between patients receiving the NPH regimen given every 4 or 6 hours. More patients in the NPH groups had blood glucose values in the target and acceptable ranges than those in the insulin aspart group (P < .001), but no statistical significance was observed between the groups receiving NPH every 4 hours and NPH every 6 hours (P = .41).Conclusions:In this study, sliding‐scale NPH insulin was demonstrated to be a safe and effective management strategy for blood glucose control in continuously tube‐fed patients; NPH insulin resulted in better blood glucose control compared with insulin aspart.
Carotid Artery Stenting in the Nation: The Influence of Hospital and Physician Volume on Outcomes
Authors: Vogel Todd R. , Dombrovskiy Viktor Y. , Graham Alan M. 
Published: December 2009

Objectives: To assess national outcomes of carotid artery stenting (CAS) with respect to hospital and practitioner volume. Methods: The 2005 to 2006 Nationwide Inpatient Sample (NIS) was used to assess CAS with respect to hospital volume, physician volume, and associated complications. Results: Eighteen thousand five hundred ninety-nine CAS interventions were identified. The top 25% was used to define high-volume hospitals (>60 CAS/2 years) and practitioners (>30 CAS/2 years). The stroke rate after CAS was significantly different between low- and high-volume hospitals (2.35% vs 1.78%, respectively; P = .0206). The stroke rate after CAS was also significantly different between low- and high-volume practitioners (2.19% vs 1.51%, P = .0243). Hospital resource use varied significantly between low- and high-volume hospitals (length of stay [LOS]: 1.64 ± 2.10 vs 1.45 ± 11.21, P = .0006; total charges: $32 261 ± 20 562 vs $30 131 ± 19 592, P = .0047) and practitioners (LOS: 1.70 ± 2.14 vs 1.36 ± 1.36; P < .0001; total charges: $33 762 ± 21 081 vs $23 957 ± 19 713; P < .0001). Conclusions: This analysis demonstrates that hospital and physician volume are associated with outcomes and utilization after CAS. High-volume hospitals and practitioners were associated with lower procedure stroke rates and decreased hospital resource utilization.
CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain–engineered monoclonal antibody
Authors: Awan Farrukh T. , Lapalombella Rosa , Trotta Rossana , Butchar Jonathan P. , Yu Bo , Benson Don M. , Roda Julie M. , Cheney Carolyn , Mo Xiaokui , Lehman Amy , Jones Jeffrey , Flynn Joseph , Jarjoura David , Desjarlais John R. , Tridandapani Susheela , Caligiuri Michael A. , Muthusamy Natarajan , Byrd John C. 
Published: December 2009

AbstractCD19 is a B cell–specific antigen expressed on chronic lymphocytic leukemia (CLL) cells but to date has not been effectively targeted with therapeutic monoclonal antibodies. XmAb5574 is a novel engineered anti-CD19 monoclonal antibody with a modified constant fragment (Fc)–domain designed to enhance binding of FcγRIIIa. Herein, we demonstrate that XmAb5574 mediates potent antibody-dependent cellular cytotoxicity (ADCC), modest direct cytotoxicity, and antibody-dependent cellular phagocytosis but not complement-mediated cytotoxicity against CLL cells. Interestingly, XmAb5574 mediates significantly higher ADCC compared with both the humanized anti-CD19 nonengineered antibody it is derived from and also rituximab, a therapeutic antibody widely used in the treatment of CLL. The XmAb5574-dependent ADCC is mediated by natural killer (NK) cells through a granzyme B–dependent mechanism. The NK cell–mediated cytolytic and secretory function with XmAb5574 compared with the nonengineered antibody is associated with enhanced NK-cell activation, interferon production, extracellular signal-regulated kinase phosphorylation downstream of Fcγ receptor, and no increased NK-cell apoptosis. Notably, enhanced NK cell–mediated ADCC with XmAb5574 was enhanced further by lenalidomide. These findings provide strong support for further clinical development of XmAb5574 as both a monotherapy and in combination with lenalidomide for the therapy of CLL and related CD19+ B-cell malignancies.
The Korean Bird Information System (KBIS) through open and public participation
Authors: Paik In-Hwan , Lim Jeongheui , Chun Byung-Sun , Jin Seon-Duck , Yu Jae-Pyoung , Lee Joon-Woo , Bhak Jong , Paek Woon-Kee 
Published: December 2009

Abstract

Background
The importance of biodiversity conservation has been increasing steadily due to its benefits to human beings. Recently, producing and managing biodiversity databases have become much easier because of the information technology (IT) advancement. This made the general public's participation in biodiversity conservation much more practical than ever. For example, an openfree web service can be devised for a wider spectrum of people to collaborate with each other for sharing biodiversity information. Bird migration is one such area of the collaboration. Korean migratory birds are usually traceable in the important routes of the East Asian-Australia Flyway (EAAF), and they play a key role as an environmental change indicator of the Earth. Therefore, the preservation of migratory birds requires an information system which involves a broader range of voluntary and interactive knowledge network to process bird information production, circulation, and dissemination.

Results
The Korean Bird Information System (KBIS) aims to construct a cooperative partnership domestically and internationally through the acquisition, management, and sharing of Korean bird information involving both expert and non-expert groups. KBIS has six goals: data standard, system linkage, data diversity, utilization, bird knowledge network, and statistics. The key features of KBIS are to provide a simple search, gallery (photographs), and community to lead the participation of numerous non-experts, especially amateur bird watchers. The function of real-time observation data submission through the internet has been accomplished. It also provides bird banding database, statistics, and taxon network for experts. Especially, the statistics part provides the user with easy understanding of ecological trends of species based on the time and region.

Conclusion
KBIS is a tool for the conservation and management of bird diversity and ecosystem that encourages users to participate by providing the openfree data access and real-time data input web-interface. It will enhance bird knowledge networking activities locally, nationally, and internationally. In addition, it provides opportunities to enhance the public awareness for the preservation of bird diversity and species information in relevant localities through the database construction and networking activities. It can be found at http://korbird.naris.go.kr.
The implementation of e-learning tools to enhance undergraduate bioinformatics teaching and learning: a case study in the National University of Singapore
Authors: Lim Shen Jean , Khan Asif Mohammad , De Silva Mark , Lim Kuan Siong , Hu Yongli , Tan Chay Hoon , Tan Tin Wee 
Published: December 2009

Abstract

Background
The rapid advancement of computer and information technology in recent years has resulted in the rise of e-learning technologies to enhance and complement traditional classroom teaching in many fields, including bioinformatics. This paper records the experience of implementing e-learning technology to support problem-based learning (PBL) in the teaching of two undergraduate bioinformatics classes in the National University of Singapore.

Results
Survey results further established the efficiency and suitability of e-learning tools to supplement PBL in bioinformatics education. 63.16% of year three bioinformatics students showed a positive response regarding the usefulness of the Learning Activity Management System (LAMS) e-learning tool in guiding the learning and discussion process involved in PBL and in enhancing the learning experience by breaking down PBL activities into a sequential workflow. On the other hand, 89.81% of year two bioinformatics students indicated that their revision process was positively impacted with the use of LAMS for guiding the learning process, while 60.19% agreed that the breakdown of activities into a sequential step-by-step workflow by LAMS enhances the learning experience

Conclusion
We show that e-learning tools are useful for supplementing PBL in bioinformatics education. The results suggest that it is feasible to develop and adopt e-learning tools to supplement a variety of instructional strategies in the future.