bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Symptom Burden Index: Development and Initial Findings from Use with Patients with Systemic Sclerosis
Authors: KALLEN MICHAEL A. , MAYES MAUREEN D. , KRISEMAN YANA L. , de ACHAVAL SOFIA B. , COX VANESSA L. , SUAREZ-ALMAZOR MARIA E. 
Published: June 2010

Objective.Our study had 3 aims: (1) to evaluate the functioning of the Symptom Burden Index (SBI) in patients with systemic sclerosis (SSc); (2) to determine the amount of burden per problem experienced by patients as well as the number of patients experiencing each measured problem area, and the number of SSc problems per patient; and (3) to characterize the burden profiles of problem area-specific subgroups of patients.Methods.We developed the SBI to determine the effect of problems in 8 major symptomatic areas of importance to patients (skin, hand mobility, calcinosis, shortness of breath, eating, bowel, sleep, and pain).Results.Sixty-two patients with SSc completed questionnaires on current disease-related problems, physical functioning, and health status. On average, patients were 53.4 years old and had had SSc for 8 years. Patients were mainly women (87%), English-speaking (87%), with diffuse SSc (63%), white (69%), married (61%), and lived with 1 or more additional household members (84%). Only 26% were employed full-time. The 3 most widely reported problem areas were pain, hand, and skin, experienced by 92%, 89%, and 88%, respectively. About one-third reported experiencing 0–5 problems and one-third 7–8 problems; individual patients experienced, on average, 5.7 problems.Conclusion.Psychometric evaluation determined that (1) summarizing SBI problem area item sets to report burden scores per problem measured is justified; (2) the 8 proposed problem areas are independent and deserve separate evaluation; and (3) burden scores correlate as expected with the Health Assessment Questionnaire-Disability Index and the Medical Outcomes Study Short-Form 36 questionnaire. The number of problems experienced and the degree of problem-associated burden that patients with SSc bear are substantial. Use of the SBI’s patient-focused measurements may aid physicians in resolving problems most directly affecting patients’ quality of life. This approach to measuring symptomatic burden in patients with chronic disease could be extended to other conditions.
"ROLE OF ALLOGENEIC TRANSPLANTATION IN MULTIPLE MYELOMA IN THE ERA OF NEW DRUGS"
Authors: Bruno Benedetto , Giaccone Luisa , Festuccia Moreno , Boccadoro Mario 
Published: June 2010

High-dose melphalan with autologous stem cell rescue has been regarded as the standard of care for patients with newly diagnosed myeloma up to the age of 65-70 years. The recent development of agents with potent anti-tumor activity such as thalidomide, lenalidomide and bortezomib has further improved overall survival and response rates. However, relapse is a continuous risk. Allografting is a potentially curative treatment for a subset of multiple myeloma patients for its well documented graft-vs-myeloma effects. However, its role has been hotly debated. Even though molecular remissions have been reported up to 50% after high-dose myeloablative conditionings, their applications, given the high toxicity, have been for long limited to younger relapsed/refractory patients. These limitations have greatly been reduced through the introduction of non-myeloablative/reduced-intensity conditionings. The introduction of new drugs, characterised by low risks of early mortality, indeed requires to define role and timing of an allograft to capture the subset of patients who may most benefit from graft-vs-myeloma effects. Ultimately, new drugs should not be viewed as mutually exclusive with an allograft. They may be employed to achieve profound cytoreduction before and enhance graft-versus-myeloma effects as consolidation/maintenance therapy after an allograft. However, this combination should be explored only in well-designed clinical trials.
Sensory Processing Disorders and Social Participation
Authors: Cosbey Joanna , Johnston Susan S. , Dunn M. Louise 
Published: June 2010

AbstractParticipation in social aspects of daily life is crucial to children’s development. Although disability status is recognized to affect children’s ability to participate in social activities, little is understood about the impact of sensory processing disorders (SPD) on children’s social participation. We examined the social participation patterns of 2 groups of children (ages 6–9): (1) children with SPD and (2) their typically developing peers. All children participated in a structured interview to report their social participation patterns, including activity patterns and social networks. We used parent and teacher questionnaires to triangulate the data gathered from the children. Results revealed that the 2 groups of children demonstrated generally similar patterns of activity preferences and use of free time but had significant differences in areas related to intensity and enjoyment of involvement and in their social networks. Implications for future research and interventions are discussed.
Novel Object Recognition in the Rat: A Facile Assay for Cognitive Function
Authors: Mathiasen Joanne R. , DiCamillo Amy 
Published: June 2010

AbstractThe rat novel object recognition (NOR) assay is a relatively high‐throughput, robust, and sensitive procedure for evaluating compounds for cognition‐enhancing activity. For the test, rats are given the opportunity to explore two identical objects for a predetermined period of time. After a delay, the animals are then presented with two objects to explore, one of which is the same as in the first exploration trial, the other a new object. Depending on the length of the delay between the two trials, the rats will either explore the novel object for a greater time period, indicating memory for the familiar object, or will explore the novel and familiar objects for the same amount of time, indicating a lack of recall or loss of memory for the familiar object presented during the initial trial. The protocol described in this unit can be used to evaluate the effects of a compound on the short‐term/working memory of adult male rats following a 24‐hr inter‐trial interval. Curr. Protoc. Pharmacol. 49:5.59.1‐5.59.15. © 2010 by John Wiley & Sons, Inc.
Palladium–Schiff base–triphenylphosphine catalyzed oxidation of alcohols
Authors: R. Dileep , Bhat Badekai Ramachandra 
Published: June 2010

AbstractNovel palladium(II)‐N‐(2‐pyridyl)‐N′‐(5‐R‐salicylidene) hydrazine triphenylphosphine complexes were synthesized and characterized by UV, IR, 1H NMR and 31P NMR spectral analysis, C, H, N analysis and magnetic susceptibility measurements. The complexes were effective in the catalytic oxidation of primary and secondary alcohols in presence of N‐methyl‐morpholine‐N‐oxide as oxidant. The oxidation reactions were carried out in dichloromethane. A mechanistic study of the above reactions has been proposed. Copyright © 2010 John Wiley & Sons, Ltd.
Magnetizable antibody‐like proteins
Authors: Dehal Prabhjyot Kaur , Livingston Christine Frances , Dunn Claire Geekie , Buick Richard , Luxton Richard , Pritchard David John 
Published: June 2010

AbstractUse of paramagnetic particles to isolate molecules or cells from complex media is well established. Typically, particles are manufactured and coated with a biological molecule that confers specific biorecognition. Incubation of particles with sample and exposure to magnetic fields isolates the species of interest. We have designed, produced and assessed magnetized fusion proteins consisting of the antigen‐binding portion of an antibody (single chain variable fraction; scFv) fused to the heavy chain of the iron‐binding protein ferritin. The fusion protein subunits expressed in E. coli assemble to form a fusion protein consisting of a ferritin sphere with scFvs on the surface. The fusion proteins were chemically magnetized by introducing a paramagnetic iron core. The resultant fusion protein was shown to be magnetizable and capable of binding target antigens. These “organic” magnetizable particles possess a number of theoretical advantages over traditional inorganic particles.
Protein chips for detection of mite allergens using Kunitz‐type protease inhibitors
Authors: Poltronieri Palmiro , Cimaglia Fabio , Santino Angelo , De Blasi Marialuce Daniela , Krizkova‐Kudlikova Iva , Liu Shaoyang , Wang Yuhong , Wang Yifen 
Published: June 2010

AbstractStored‐food and house‐dust arthropods include many species of mites and beetles that affect human health. For diagnostic tests proteases such as trypsin are utilized as they are indicators of the presence of allergen contaminants in food. We recently characterized Kunitz‐type protease inhibitors (KPIs) from Solanum palustre. Here we studied biotechnological applications of KPI‐B1 and ‐B4. We manufactured a protein chip with immobilized KPI‐B1 and ‐B4 and showed trypsin/chymotrypsin‐binding specificity, indicating that the recombinant proteins have protease selectivity. We employed the protein chip to capture mite proteins belonging to the protease family with polyclonal anti‐mite antibodies. The mite diagnostic chip can be useful for detecting mite allergens.
Development of a validated high‐throughput LC‐ESI‐MS method for determination of sirolimus on dried blood spots
Authors: Rao R. Nageswara , Maurya Pawan K. , Ramesh M. , Srinivas R. , Agwane Sachin B. 
Published: June 2010

AbstractA high‐throughput liquid chromatography–electrospray ionization mass spectrometric (LC–ESI‐MS) method for screening of sirolimus on dried blood spots (DBS) was developed and validated. It involves solvent extraction of a punch of DBS followed by reversed‐phase LC on a relatively new monolithic column consisting of a silica rod with bimodal pore structure and detection by ESI‐MS. The run time was less than 3 min with a very low backpressure at a flow rate of 0.5 mL/min. The method can analyze more than 100 samples in an 8 h working day, including sample preparation. The assay was linear from 1 to 100 ng/mL. The mean recovery was 92.42%. The mean inter‐day and intra‐day precisions were 1.23 and 1.41%, respectively. The developed method is simple, rapid and useful for clinical applications. Copyright © 2010 John Wiley & Sons, Ltd.
Impacts from climate change on organizations: a conceptual foundation
Authors: Winn Monika , Kirchgeorg Manfred , Griffiths Andrew , Linnenluecke Martina K. , Günther Elmar 
Published: June 2010

AbstractPhysical impacts from climate change already pose major challenges for organizations, and the trend is rising. Organization theorists, however, have barely begun to systematically consider the organizational impacts of more and increasingly intense storms, floods, droughts, fires, sea level rise or changing growing seasons as part of their domain of study. Eight organizationally relevant dimensions of climate impacts are identified: severity, temporal scale, spatial scale, predictability, mode, immediacy, state change potential and accelerating trend potential. Combined, their scale, scope and systemic uncertainty suggest future conditions of systemic hyperturbulence in organizational environments, defined here as ‘massive discontinuous change’ (MDC). To build a conceptual foundation for organizations to respond and adapt to MDC, the paper examines contributions from literatures on the management of sustainability, crisis, risk, resilience and adaptive organizational change. It highlights gaps for addressing both business challenges and opportunities from MDC, and suggests avenues for future research. Copyright © 2010 John Wiley & Sons, Ltd and ERP Environment.
Why are Kenyan teachers still using corporal punishment eight years after a ban on corporal punishment?
Authors: Mweru Maureen 
Published: May 2010

AbstractThe Kenyan government banned corporal punishment in Kenyan schools in 2001 and enacted the Children's Act (Government of Kenya, 2001) which entitles children to protection from all forms of abuse and violence. Kenya is also a signatory to the Convention on the Rights of the Child (United Nations, 1990) which states that discipline involving violence is unacceptable. In spite of this, the use of corporal punishment continues in Kenyan schools. This study therefore sought to identify the reasons behind the use of corporal punishment by Kenyan teachers and teachers' awareness of existing laws on the use of violence on children. Data collected through focus group discussions showed that teachers were aware of existing laws prohibiting the use of corporal punishment in schools. Their reasons for using corporal punishment included the belief that it was the most effective way to discipline children and that parents had authorised its use. This study has shown that, although the Kenyan government has introduced laws to protect children, teachers will readily break them if they believe it is for the children's good. This paper therefore recommends the involvement of the Kenyan government in training teachers on non‐violent ways of disciplining children. Copyright © 2010 John Wiley & Sons, Ltd.
ChemInform Abstract: Recrystallization of Oxygen Ion Implanted Ba0.7Sr0.3TiO3 Thin Films.
Authors: Liedtke R. , Hoffmann S. , Waser R. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Syntheses, Structures, and Physical Properties of LnAsTe (Ln: La, Pr, Sm, Gd, Dy, Er).
Authors: Huang Fu Qiang , Brazis Paul , Kannewurf Carl R. , Ibers James A. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Structures, and Reactivity of Two Compounds Containing the Tancoite‐like [Ga(HPO4)2F]2‐∞ Chain.
Authors: Walton Richard I. , Millange Franck , O'Hare Dermot , Paulet Capucine , Loiseau Thierry , Ferey Gerard 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Hydrogenation of Amino Ketones Using Chiral RuCl2(diphosphine)(1,2‐diamine) Complexes.
Authors: Ohkuma Takeshi , Ishii Dai , Takeno Hiroshi , Noyori Ryoji 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Facile Route to Amino‐azines.
Authors: Rostamizadeh Shahnaz , Keshavarz Housainali 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Useful Synthesis of Diethyl 1‐Substituted Vinylphosphonates.
Authors: Krawczyk H. , Koszuk J. , Bodalski R. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Rh‐Catalyzed Enyne Cycloisomerization.
Authors: Cao Ping , Wang Bin , Zhang Xumu 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Formation of Carbon—Nitrogen Bonds via a Novel Radical Azidation Process.
Authors: Ollivier Cyril , Renaud Philippe 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Regioselective Thiocarbonylation of Conjugated Dienes via Palladium‐Catalyzed Three‐Component Coupling Reactions.
Authors: Xiao Wen‐Jing , Vasapollo Giuseppe , Alper Howard 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Selective Deprotection of Alkyl t‐Butyldimethylsilyl Ethers in the Presence of Aryl t‐Butyldimethylsilyl Ethers with Bismuth Bromide.
Authors: Bajwa Joginder S. , Vivelo James , Slade Joel , Repic Oljan , Blacklock Thomas 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Convenient Method for the Preparation of Hydroxamic Acids.
Authors: Reddy A. Sekar , Kumar M. Suresh , Reddy G. Ravindra 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Thiophenyl Substituted Cyclohexa‐2,4‐dien‐1‐one and Its Photocleavage Coupling Reaction with Amines.
Authors: Kwon Tae Woo , Kim Young Mee , Song Suk Jin , Kwon Yong Uk , Chung Sung Kee 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regioselectivity of the Ru‐Catalyzed Intramolecular [5 + 2] Cycloaddition.
Authors: Trost Barry M. , Shen Hong C. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mild and Efficient Dehydration of Oximes to Nitriles Mediated by the Burgess Reagent.
Authors: Miller Chris P. , Kaufman David H. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Syntheses of Novel Liquid Crystalline Compounds with Partially Fluorinated Side Chains.
Authors: Uhm Yong Sup , Kim Yong Bai , Kim Sung Hoon 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ni(II)/Zn‐Mediated Chemoselective Arylation of Aromatic Aldehydes: Facile Synthesis of Diaryl Carbinols.
Authors: Majumdar Kanak Kanti , Cheng Chien‐Hong 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Diels—Alder Approach to Tetralin‐Based Constrained α‐Amino Acid Derivatives.
Authors: Kotha Sambasivarao , Ganesh Thota , Ghosh Arun Kumar 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Multibridged [3n]Cyclophanes. Part 10. Formation and Structural Features of Novel Cage Compounds with a Pentacyclo [6.4.0.03,7.04,11.05,10]dodecane Skeleton via Photolysis of [33](1,3,5)cyclophane.
Authors: Matohara Kumi , Lim Chultack , Yasutake Mikio , Nogita Rika , Koga Toru , Sakamoto Youichi , Shinmyozu Teruo 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Sodium Percarbonate as an Oxygen Source for MTO Catalyzed Epoxidations.
Authors: Vaino Andrew R. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The First Stable Enantiomerically Pure Chiral N—H Oxaziridines: Synthesis and Reactivity.
Authors: Page Philip C. Bulman , Murrell Victor L. , Limousin Corinne , Laffan David D. P. , Bethell Donald , Slawin Alexandra M. Z. , Smith Timothy A. D. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regioselective Intramolecular Oxidation of Phenols and Anisoles by Dioxiranes Generated in situ.
Authors: Yang Dan , Wong Man‐Kin , Yan Zheng 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.