bluuebunny/crossref_metadata_2025_split huggingface dataset:
An adapted postdonation motivational interview enhances blood donor retention
Authors: Sinclair Kadian S. , Campbell Tavis S. , Carey Patricia M. , Langevin Eric , Bowser Brent , France Christopher R. 
Published: April 2010

BACKGROUND: Blood donors may hold conflicting thoughts about future donation. While they may perceive the direct benefit to themselves and others, they often report compelling reasons not to give again. As a result the standard encouragements to return may not be sufficient to motivate some donors. This study examined the effects of a postdonation adapted motivational interview (AMI) on blood donor attitudes and repeat donation behavior.STUDY DESIGN AND METHODS: Donors (n = 215) were randomly assigned to either an AMI or a no‐interview control group. Approximately 1 month after their index donation, donors in the AMI group completed a brief telephone interview to clarify individual‐specific motivations and values concerning blood donation and address potential barriers. They were then asked to complete questionnaires regarding donation attitudes, anxiety, self‐efficacy, and intention to donate. Donors in the control group were also contacted 1 month after donation and asked to complete the same series of questionnaires.RESULTS: Donors in the AMI group reported greater intention to provide a future donation (F = 8.13, p < 0.05), more positive donation attitudes (F = 4.59, p < 0.05), and greater confidence in their ability to avoid adverse reactions (F = 10.26, p < 0.01). Further, AMI was associated with higher rates of attempted donation at 12 months (odds ratio, 2.48; 95% confidence interval, 1.27‐4.87).CONCLUSION: Application of an AMI may be an effective strategy to increase the donor pool by enhancing retention of existing donors.
Mapping and Ablation of Frequent Post‐Infarction Premature Ventricular Complexes
Authors: SARRAZIN JEAN‐FRANCOIS , GOOD ERIC , KUHNE MICHAEL , ORAL HAKAN , PELOSI FRANK , CHUGH AMAN , JONGNARANGSIN KRIT , CRAWFORD THOMAS , EBINGER MATTHEW , MORADY FRED , BOGUN FRANK 
Published: April 2010

Mapping of Post‐Infarction PVCs. Introduction: Premature ventricular complexes (PVCs) occur frequently in patients with heart disease. The sites of origin of PVCs in patients with prior myocardial infarction and the response to catheter ablation have not been systematically assessed. Methods and Results: In 28 consecutive patients (24 men, age 60 ± 10, ejection fraction [EF] 0.37 ± 0.14) with remote myocardial infarction referred for catheter ablation of symptomatic refractory PVCs, the PVCs were mapped by activation mapping or pace mapping using an irrigated‐tip catheter in conjunction with an electroanatomic mapping system. The site of origin (SOO) was classified as being within low‐voltage (scar) tissue (amplitude ≤1.5 mV) or tissue with preserved voltage (>1.5 mV). The SOO was confined to endocardial scar tissue in 24/28 patients (86%). The SOO was outside of scar in 3 patients and could not be identified in 1 patient. At the SOO, local endocardial activation preceded the PVC by 46 ± 19 ms, and the electrogram amplitude during sinus rhythm was 0.48 ± 0.34 mV. The PVCs were effectively ablated in 25/28 patients (89%), resulting in a decrease in PVC burden on a 24‐hour Holter monitor from 15.6 ± 12.3% to 2.4 ± 4.2% (P < 0.001). The SOO most often was confined to scar tissue located in the left ventricular septum and the papillary muscles. Conclusion: Similar to post‐infarction ventricular tachycardia, PVCs after remote myocardial infarction most often originate within scar tissue. Catheter ablation of these PVCs has a high‐success rate. (J Cardiovasc Electrophysiol, Vol. 21, pp. 1002‐1008, September 2010)
Acidosis Impairs the Protective Role of hERG K+ Channels Against Premature Stimulation
Authors: DU CHUN YUN , ADENIRAN ISMAIL , CHENG HONGWEI , ZHANG YI HONG , EL HARCHI AZIZA , MCPATE MARK J. , ZHANG HENGGUI , ORCHARD CLIVE H. , HANCOX JULES C. 
Published: April 2010

Acidosis and the hERG K+ Channel. Introduction: Potassium channels encoded by human ether‐à‐go‐go‐related gene (hERG) underlie the cardiac rapid delayed rectifier K+ channel current (IKr). Acidosis occurs in a number of pathological situations and modulates a range of ionic currents including IKr. The aim of this study was to characterize effects of extracellular acidosis on hERG current (IhERG), with particular reference to quantifying effects on IhERG elicited by physiological waveforms and upon the protective role afforded by hERG against premature depolarizing stimuli. Methods and Results: IhERG recordings were made from hERG‐expressing Chinese Hamster Ovary cells using whole‐cell patch‐clamp at 37°C. IhERG during action potential (AP) waveforms was rapidly suppressed by reducing external pH from 7.4 to 6.3. Peak repolarizing current and steady state IhERG activation were shifted by ∼+6 mV; maximal IhERG conductance was reduced. The voltage‐dependence of IhERG inactivation was little‐altered. Fast and slow time‐constants of IhERG deactivation were smaller across a range of voltages at pH 6.3 than at pH 7.4, and the contribution of fast deactivation increased. A modest acceleration of the time‐course of recovery of IhERG from inactivation was observed, but time‐course of activation was unaffected. The amplitude of outward IhERG transients elicited by premature stimuli following an AP command was significantly decreased at lower pH. Computer simulations showed that after AP repolarization a subthreshold stimulus at pH 7.4 could evoke an AP at pH 6.3. Conclusion: During acidosis the contribution of IhERG to action potential repolarization is reduced and hERG may be less effective in counteracting proarrhythmogenic depolarizing stimuli. (J Cardiovasc Electrophysiol, Vol. 21, pp. 1160‐1169)
Persistence of Pulmonary Vein Isolation After Robotic Remote‐Navigated Ablation for Atrial Fibrillation and its Relation to Clinical Outcome
Authors: WILLEMS STEPHAN , STEVEN DANIEL , SERVATIUS HELGE , HOFFMANN BORIS A. , DREWITZ IMKE , MÜLLERLEILE KAI , AYDIN MUHAMMET ALI , WEGSCHEIDER KARL , SALUKHE TUSHAR V. , MEINERTZ THOMAS , ROSTOCK THOMAS 
Published: April 2010

Robotic Remote Ablation for AF. Aims: A robotic navigation system (RNS, Hansen™) has been developed as an alternative method of performing ablation for atrial fibrillation (AF). Despite the growing application of RNS‐guided pulmonary vein isolation (PVI), its consequences and mechanisms of subsequent AF recurrences are unknown. We investigated the acute procedural success and persistence of PVI over time after robotic PVI and its relation to clinical outcome. Methods and Results: Sixty‐four patients (60.7 ± 9.8 years, 53 male) with paroxysmal AF underwent robotic circumferential PVI with 3‐dimensional left atrial reconstruction (NavX™). A voluntary repeat invasive electrophysiological study was performed 3 months after ablation irrespective of clinical course. Robotic PVI was successful in all patients without complication (fluoroscopy time: 23.5 [12–34], procedure time: 180 [150–225] minutes). Fluoroscopy time demonstrated a gradual decline but was significantly reduced after the 30th patient following the introduction of additional navigation software (34 [29–45] vs 12 [9–17] minutes; P < 0.001). A repeat study at 3 months was performed in 63% of patients and revealed electrical conduction recovery in 43% of all PVs. Restudied patients without AF recurrence (n = 28) showed a significantly lower number of recovered PVs (1 (0–2) vs 2 (2–3); P = 0.006) and a longer LA‐PV conduction delay than patients with AF recurrences (n = 12). Persistent block of all PVs was associated with freedom from AF in all patients. At 3 months, 67% of patients were free of AF, while reablation of recovered PVs led to an overall freedom from AF in 81% of patients after 1 year. Conclusion: Robotic PVI for PAF is safe, effective, and requires limited fluoroscopy while yielding comparable success rates to conventional ablation approaches with PV reconduction as a common phenomenon associated with AF recurrences. (J Cardiovasc Electrophysiol, Vol. 21, pp. 1079‐1084)
Validation of the Professional Practice Environment Scale in Australian General Practice
Authors: Halcomb Elizabeth J. , Davidson Patricia M. , Caldwell Belinda , Salamonson Yenna , Rolley John X. 
Published: April 2010

Abstract Purpose: To validate the Professional Practice Environment Scale (PPE) in Australian general practice. Methods: The PPE was modified slightly for appropriateness for the practice setting and administered to a sample of 342 Australian general practice nurses via an online survey tool. The factor structure of the 38‐item PPE was examined using principal components analysis with Varimax rotation. Findings: An eight‐factor solution accounted for 71.6% of the variance. Low factor loading (<0.3) or cross‐component loadings were detected in eight items. A comparison of Cronbach's alpha values demonstrated little change in the deletion of eight items from four of the eight related components. Conclusions: Findings demonstrated that a 30‐item version of the PPE was reliable and valid for use to assess the professional practice environment of nurses working in Australian general practice. Clinical Relevance: A tool to measure the professional practice environment in general practice is important as it will assist in monitoring the impact of the work environment on the recruitment, retention, and satisfaction of nurses in this setting.
Emergency Department Information System Adoption in the United States
Authors: Landman Adam B. , Bernstein Steven L. , Hsiao Allen L. , Desai Rani A. 
Published: April 2010

AbstractObjectives:  The American Recovery and Reinvestment Act of 2009 incentivizes adoption of health care information technology (HIT) based on support for specific standards, policies, and features. Limited data have been published on national emergency department information systems (EDIS) adoption, and to our knowledge, no prior studies have considered functionality measures. This study determined current national estimates of EDIS adoption using both single‐response rates of EDIS adoption and a novel feature‐based definition and also identified emergency department (ED) characteristics associated with EDIS use.Methods:  The 2006 National Hospital Ambulatory Medical Care Survey, a nationally representative sample of ED visits that also surveyed participating EDs on EDIS, was used to estimate EDIS adoption. EDIS adoption rates were calculated using two definitions: 1) single‐response—response to a single survey question as to whether the EDIS was complete, partial, or none; and 2) feature‐based—based on the reported features supported by the EDIS, systems were categorized as fully functional, basic, other, or none. The relationship of EDIS adoption to specific ED characteristics such as facility type and location was also examined.Results:  Using the single‐response classification, 16.1% of EDs had a complete EDIS, while 30.4% had a partial EDIS, and 53.5% had none. In contrast, using a feature‐based categorization, 1.7% EDs had a fully functional EDIS, 12.3% had basic, 32.1% had other, and 53.9% had none. In multivariable analysis, urban EDs were significantly more likely to have a fully functional or basic EDIS than were rural EDs. Pediatric EDs were significantly more likely than general EDs to have other EDIS.Conclusions:  Despite more optimistic single‐response estimates, fewer than 2% of our nation’s EDs have a fully functional EDIS. EDs in urban areas and those specializing in the care of pediatric patients are more likely to support EDIS. Accurate and consistent EDIS adoption estimates are dependent on whether there are standardized EDIS definitions and classifications of features. To realize the potential value of EDIS for improved emergency care, we need to better understand the extent and correlates of the diffusion of this technology and increase emergency medicine engagement in national HIT policy‐making.Academic Emergency Medicine 2010; 17:536–544 © 2010 by the Society for Academic Emergency Medicine
The Risk of Intra‐abdominal Injuries in Pediatric Patients with Stable Blunt Abdominal Trauma and Negative Abdominal Computed Tomography
Authors: Hom Jeffrey 
Published: April 2010

AbstractObjectives:  This review examines the prevalence of intra‐abdominal injuries (IAI) and the negative predictive value (NPV) of an abdominal computed tomography (CT) in children who present with blunt abdominal trauma.Methods:  MEDLINE, EMBASE, and Cochrane Library databases were searched. Studies were selected if they enrolled children with blunt abdominal trauma from the emergency department (ED) with significant mechanism of injury requiring an abdominal CT. The primary outcome measure was the rate of IAI in patients with negative initial abdominal CT. The secondary outcome measure was the number of laparotomies, angiographic embolizations, or repeat abdominal CTs in those with negative initial abdominal CTs.Results:  Three studies met the inclusion criteria, comprising a total of 2,596 patients. The overall rate of IAI after a negative abdominal CT was 0.19% (95% confidence interval [CI] = 0.08% to 0.44%). The overall NPV of abdominal CT was 99.8% (95% CI = 99.6% to 99.9%). There were five patients (0.19%, 95% CI = 0.08% to 0.45%) who required additional intervention despite their initial negative CTs: one therapeutic laparotomy for bowel rupture, one diagnostic laparotomy for mesenteric hematoma and serosal tear, and three repeat abdominal CTs (one splenic and two renal injuries). None of the patients in the latter group required surgery or blood transfusion.Conclusions:  The rate of IAI after blunt abdominal trauma with negative CT in children is low. Abdominal CT has a high NPV. The review shows that it might be safe to discharge a stable child home after a negative abdominal CT.ACADEMIC EMERGENCY MEDICINE 2010; 17:469–475 © 2010 by the Society for Academic Emergency Medicine
Emergency Department Patient Volume and Troponin Laboratory Turnaround Time
Authors: Hwang Ula , Baumlin Kevin , Berman Jeremy , Chawla Neal K. , Handel Daniel A. , Heard Kennon , Livote Elayne , Pines Jesse M. , Valley Morgan , Yadav Kabir 
Published: April 2010

AbstractObjectives:  Increases in emergency department (ED) visits may place a substantial burden on both the ED and hospital‐based laboratories. Studies have identified laboratory turnaround time (TAT) as a barrier to patient process times and lengths of stay. Prolonged laboratory study results may also result in delayed recognition of critically ill patients and initiation of appropriate therapies. The objective of this study was to determine how ED patient volume itself is associated with laboratory TAT.Methods:  This was a retrospective cohort review of patients at five academic, tertiary care EDs in the United States. Data were collected on all adult patients seen in each ED with troponin laboratory testing during the months of January, April, July, and October 2007. Primary predictor variables were two ED patient volume measures at the time the troponin test was ordered: 1) number of all patients in the ED/number of beds (occupancy) and 2) number of admitted patients waiting for beds/beds (boarder occupancy). The outcome variable was troponin turnaround time (TTAT). Adjusted covariates included patient characteristics, triage severity, season (month of the laboratory test), and site. Multivariable adjusted quantile regression was carried out to assess the association of ED volume measures with TTAT.Results:  At total of 9,492 troponin tests were reviewed. Median TTAT for this cohort was 107 minutes (interquartile range [IQR] = 73–148 minutes). Median occupancy for this cohort was 1.05 patients (IQR = 0.78–1.38 patients) and median boarder occupancy was 0.21 (IQR = 0.11–0.32). Adjusted quantile regression demonstrated a significant association between increased ED patient volume and longer times to TTAT. For every 100% increase in census, or number of boarders over the number of ED beds, respectively, there was a 12 (95% confidence interval [CI] = 9 to 14) or 33 (95% CI = 24 to 42)‐minute increase in TTAT.Conclusions:  Increased ED patient volume is associated with longer hospital laboratory processing times. Prolonged laboratory TAT may delay recognition of conditions in the acutely ill, potentially affecting clinician decision‐making and the initiation of timely treatment. Use of laboratory TAT as a patient throughput measure and the study of factors associated with its prolonging should be further investigated.ACADEMIC EMERGENCY MEDICINE 2010; 17:501–507 © 2010 by the Society for Academic Emergency Medicine
ORIGINAL ARTICLE: Epithelioid hemangioendothelioma in the right auricle of an adult, male Rhesus macaque (Macaca mulatta)
Authors: Lombardini E.D. , Virmani R. , Blanchard T.W. , Lafond J.F. , Ménard S. , Doré M. 
Published: April 2010

Abstract Background  A 9‐year‐old, male castrate, Rhesus macaque was euthanized following a prolonged history of chronic renal failure.Results  Necropsy revealed a proliferative lesion within the right cardiac auricle composed of neoplastic epithelioid cells which infiltrated the myocardium and frequently exhibited intracytoplasmic luminae. Cells multifocally exhibited strong cytoplasmic immunoreactivity for Factor VIII‐related protein (von Willebrand’s factor).Conclusions  The histological characteristics of this tumor are consistent with a diagnosis of epithelioid hemangioendothelioma, an intermediate‐grade vasoformative neoplasm which has to our knowledge not previously been reported in the heart of a non‐human species.
Retrospective case–control study of hyperglycemia in group‐housed, mature female cynomolgus macaques (Macaca fascicularis)
Authors: Bauer S.A. , Leslie K.E. , Pearl D.L. , Fournier J. , Turner P.V. 
Published: April 2010

AbstractBackground  Captive cynomolgus macaques are prone to obesity, increasing their risk for developing hyperglycemia and type 2 diabetes mellitus (T2DM). Social rank may be a contributing risk factor predisposing macaques to adverse health events.Methods  Using retrospective health records from 259 animals, a matched case–control study was conducted to assess risk factors for developing hyperglycemia in group‐housed, adult females aged 10 or older. Univariable exact and conditional logistic regression models were used to analyze the data.Result  The odds of developing hyperglycemia were significantly greater in animals with more frequent counts of injury. Similarly, subordinate animals had higher odds of developing hyperglycemia than affiliates.Conclusions  Subordinate social status may increase the risk of hyperglycemia in mature female cynomolgus macaques. Opportunities for subordinates to alter feeding strategies are reduced in captivity. This may be associated with increased social stress around feeding, and for animals housed long‐term could predispose them to obesity and hyperglycemia.
Barrett’s esophagus and Cornelia de Lange Syndrome
Authors: Macchini Francesco , Fava Giorgio , Selicorni Angelo , Torricelli Maurizio , Leva Ernesto , Valadè Alberto 
Published: April 2010

AbstractAim:  To review the records of Cornelia de Lange Syndrome (CDLS) children, affected by Gastro‐oesophageal reflux disease (GERD), to detect the presence of Barrett’s Esophagus (BE).Methods:  A total of 62 CDLS patients were investigated for GERD (1 month–35 years). In all of them a pH‐metry, an upper endoscopy with multiple biopsies and a complete radiologic digestive evaluation were carried out. BE was diagnosed in case of replacement of oesophageal mucosa by specialized intestinal‐type columnar mucosa. Anti‐reflux surgery was considered in case of persistence of BE after medical therapy. Follow‐up (mean 3.5 years) consisted in endoscopy every 6 months .Results:  Gastro‐oesophageal reflux disease was found in 50 CDLS patients (80%) and BE in six of them (12% of the GERD group, 9.6% of the entire population, mean age 17 years, range 6–32 years). A short segment BE was observed in three patients, a long one in two patients and an infiltrating adenocarcinoma of the lower oesophagus in one patient.Conclusions:  A higher frequency of BE in CDLS patients than in a normal population is found. A delayed diagnosis because of atypical GERD symptoms and an altered intestinal motility as a result of neurological impairment can be recognized as the main cause.
Guided Surgery and Presurgical Prosthesis: Preliminary Results of 33 Fully Edentulous Maxillae Treated in Accordance with the NobelGuide® Protocol
Authors: Gillot Luc , Noharet Renaud , Cannas Bernard 
Published: April 2010

ABSTRACTObjective: The aim of this study was to present the preliminary results of 33 edentulous maxillary patients treated using the Nobelguide® (Nobel Biocare AB, Göteborg, Sweden) technique.Materials and Methods: Thirty‐three patients were treated according to the conventional protocol of the Nobelguide® technique in two clinical centers. This group of patients received 211 implants. Monitoring was carried out for over 12–51 months, depending on the patient. The Nobelguide® protocol was used for all patients.Results: Of the 211 implants loaded, four were lost (1.9%). The implant survival rate was therefore 98.1%. The prosthetic survival rate was 100%. There were some per‐operative complications (four) and some postoperative complications (10 fractures of resin).Conclusion: These preliminary results seemed rather promising. These were the first cases of experienced surgeons who needed to learn a new implant placement protocol. It was clear that analysis and understanding of the system were essential in order to obtain such a success. Only one implant was replaced without there being any impact on the prosthesis survival rate which is 100%.
The Segmental Down Fracture for Vertical Bone Augmentation: Case Report
Authors: Langer Burton 
Published: April 2010

ABSTRACTThe aim of this singular case report is to describe correction of a severe vertical bone and soft tissue deficiency in the maxillary esthetic zone. The defect was corrected by using a single stage segmental down fracture technique. Treatment results were followed for 9 years, revealing stable bone, soft tissue, and bone levels adjacent to the dental implants.
Mesh fixation in laparoscopic totally extraperitoneal inguinal hernioplasty by percutaneous subcutaneous suture technique
Authors: Tang Chun‐Kit , Wong Kenny Che‐Yung 
Published: April 2010

Aim:  The method of mesh fixation remains an issue of argument in laparoscopic totally extraperitoneal inguinal hernia repair. Laparoscopic staplers, bioactive tissue glues and tacks had been used by various institutions for the same purpose. In the present article, we describe the percutaneous subcutaneous suture technique, which is an inexpensive method of mesh fixation in laparoscopic inguinal hernia repair.Methods:  We carried out a retrospective case series review of cases with laparoscopic totally extraperitoneal inguinal hernia repair carried out in Pok Oi Hospital, Hong Kong from 19 November 2008 to 4 June 2009. Mesh fixation by percutaneous subcutaneous suture technique was carried out for patients with large hernial defects (≥ 4 cm), bilateral or recurrent hernias.Results:  One out of 31 hernioplasties (3.2%) carried out with mesh fixation was complicated by recurrence up to 3 months of median follow up.Conclusion:  We describe our alternative method of mesh fixation by percutaneous subcutaneous suture technique in laparoscopic totally extraperitoneal inguinal hernia repair. However, further clinical studies are required to elaborate the benefits and long‐term results of this method.
Preference for Collpa Water by Frugivorous Bats (Artibeus): An Experimental Approach
Authors: Bravo Adriana , Harms Kyle E. , Emmons Louise H. 
Published: April 2010

ABSTRACTSeveral species of stenodermatine bats congregate in large numbers at collpas in southeastern Peru to drink water. We conducted the first experimental tests of preference for collpa water by representative bats. Artibeus species preferred mineral‐rich collpa water over water from other sources, supporting the hypothesis that they seek resources (especially sodium) at collpas.