bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geometric optimization of the space around the buildings based on the improvement of thermal comfort efficiency of the building
Authors: Cui Guolian 
Published: June 2024

Abstract
This stud introduces a pioneering investigation into the geometric optimization of building surroundings to elevate thermal comfort efficiency and foster sustainable development within the construction industry. Employing the ENVI-met simulation tool and a novel crow search optimization algorithm, the research rigorously quantifies occupants' dissatisfaction utilizing the predicted percentage dissatisfied model, meticulously considering various environmental parameters. The simulations are based on the weather data of Nanjing, China, and the numerical results were validated against the observed data. The results reveal a remarkable 7% reduction in energy consumption and a corresponding 7.2% decrease in CO2 emissions compared to baseline configurations, underscoring the substantial impact of the proposed crow search algorithm. Notably, the study identifies an optimal configuration, characterized by a 30% vegetation cover, west–east orientation, and a three-story building, highlighting the algorithm's effectiveness in identifying configurations that concurrently enhance thermal comfort and mitigate energy consumption. These findings highlight the critical influence of geometric factors on thermal performance and underscore the significance of integrating innovative methodologies to address contemporary challenges in sustainable building design. By offering novel insights and practical solutions, this research contributes to advancing sustainable practices in architecture and urban planning, ultimately promoting occupant well-being and fostering energy-efficient construction practices.
Global existence and steady states of the density-suppressed motility model with strong Allee effect
Authors: Song Cui , Wang Zhi-Cheng , Feng Zhaosheng 
Published: June 2024

Abstract
This paper considers a density-suppressed motility model with a strong Allee effect under the homogeneous Neumman boundary condition. We first establish the global existence of bounded classical solutions to a parabolic–parabolic system over an $N $-dimensional $\mathbf{(N\le 3)}$ bounded domain $\varOmega $, as well as the global existence of bounded classical solutions to a parabolic–elliptic system over the multidimensional bounded domain $\varOmega $ with smooth boundary. We then investigate the linear stability at the positive equilibria for the full parabolic case and parabolic–elliptic case, respectively, and find the influence of Allee effect on the local stability of the equilibria. By treating the Allee effect as a bifurcation parameter, we focus on the one-dimensional stationary problem and obtain the existence of non-constant positive steady states, which corresponds to small perturbations from the constant equilibrium $(1,1)$. Furthermore, we present some properties through theoretical analysis on pitchfork type and turning direction of the local bifurcations. The stability results provide a stable wave mode selection mechanism for the model considered in this paper. Finally, numerical simulations are performed to demonstrate our theoretical results.
Recurrent Group B Streptococcus Neonatal Invasive Infections, France, 2007–2021
Authors: Sbaa Ghalia , Delettre Nicolas , Guyonnet Cécile , Le Huu Nghia Sébastien , Joubrel-Guyot Caroline , Plainvert Céline , Poyart Claire , Tazi Asmaa 
Published: June 2024

Abstract
Recurrence is a rare complication of group B Streptococcus (GBS) neonatal infections. We conducted a retrospective observational study on GBS neonatal invasive infections in France from 2007 to 2021. A total of 1527 cases were reported, of which 36 (2.36%) were recurrent. Recurrence mainly concerned preterm (68%) and low-birth-weight (72%) infants and was associated with the hypervirulent GBS clonal complex 17 (83%; odds ratio, 2.86 [95% confidence interval, 1.18–6.92]). No β-lactam–tolerant strains were identified, and bacterial whole-genome sequencing could not reveal any specific feature associated with recurrence. Large-cohort studies should be undertaken to address the optimal management of these uncommon diseases.
Advanced Age Worsens Respiratory Function and Pulmonary Inflammation After Burn Injury and This Correlates With Changes in the Fecal Microbiome in Mice
Authors: McMahan Rachel H , Boe Devin , Giesy Lauren E , Najarro Kevin M , Khair Shanawaj , Walrath Travis , Frank Daniel N , Kovacs Elizabeth J 
Published: June 2024

Abstract
Cutaneous burn injury in the elderly is associated with poor clinical outcomes and increased pulmonary-related complications. We and others have shown that burn injury triggers a cascade of inflammatory mediators which increase gut permeability and dysbiosis of the fecal microbiota and this is more dramatic in the aged. Since crosstalk between intestinal microbes and the lung, termed the “gut-lung axis,” impacts immunity and homeostasis in the airway, we hypothesized that the increased intestinal dysbiosis in age and burn injury may contribute to excessive pulmonary inflammation and poor prognosis after injury. To explore this hypothesis, we used a clinically relevant murine model of burn injury in which young and aged mice are subjected to a 12% TBSA dorsal scald burn or sham injury. About 24 h after injury, lung function was assessed and lungs and feces were collected for analysis of inflammatory mediators and fecal microbial species. The results show that, when compared to younger mice, burn injury in aged mice triggers a decline in respiratory function and exacerbates pulmonary inflammation. In addition to heightened levels of the neutrophil recruiting chemokine CXCL1, aged mice displayed a profound increase in the pro-inflammatory protein, calprotectin, in the lung after burn injury. Comparison of the fecal microbiome and inflammatory markers in the lung revealed unique, age-dependent, correlation patterns between individual taxa and pulmonary inflammation. Taken together, these findings suggest that the postburn dysbiosis of the gut flora in aged mice may contribute to the changes in pulmonary inflammatory profiles.
Yield analysis and corn earworm feeding in Bt and non-Bt corn hybrids across diverse locations
Authors: Reisig Dominic , Heiniger Ryan 
Published: June 2024

Abstract
Corn, Zea mays L. (Poales: Poaceae), growers in the US Cotton Belt are required to plant 20% of total corn acres to non-Bt hybrids for resistance management (non-Bt refuge). Most growers do not meet this requirement, in part, because they perceive non-Bt hybrids to yield less than Bt hybrids. We planted multiple non-Bt and Bt hybrids from a single company in small-plot replicated trials at a single location from 2019 to 2023, as well as in small-plot replicated trials at multiple locations during 2022 and 2023. In the single location, we measured kernel injury from corn earworm, Helicoverpa zea Boddie (Lepidoptera: Noctuidae), and we recorded yield at all locations. In the single location trial, yields only separated among hybrids in 3 out of 5 years. In the multiple location trial, yields were variable between both years. We found that Bt hybrids tended to yield higher than non-Bt hybrids overall, but this was influenced by the inclusion of non-Bt hybrids that had a lower overall genetic yield potential in the environments we tested them in. In both tests, when hybrids were analyzed during each year, both Bt and non-Bt hybrids were among the statistically highest yielders. Our study demonstrates the importance of comparing multiple Bt and non-Bt hybrids to draw yield comparisons. This highlights the need for corn seed company breeders to put effort into improving yield for non-Bt hybrids. Hopefully this effort will translate into increased planting of non-Bt refuge corn for growers in the US Cotton Belt.
Complement or insult: the emerging link between complement cascade deficiencies and pathology of myeloid malignancies
Authors: Oakes Alissa , Liu Yuchen , Dubielecka Patrycja M 
Published: June 2024

Abstract
The complement cascade is an ancient and highly conserved arm of the immune system. The accumulating evidence highlights elevated activity of the complement cascade in cancer microenvironment and emphasizes its effects on the immune, cancer, and cancer stroma cells, pointing to a role in inflammation-mediated etiology of neoplasms. The role the cascade plays in development, progression, and relapse of solid tumors is increasingly recognized, however its role in hematological malignancies, especially those of myeloid origin, has not been thoroughly assessed and remains obscure. As the role of inflammation and autoimmunity in development of myeloid malignancies is becoming recognized, in this review we focus on summarizing the links that have been identified so far for complement cascade involvement in the pathobiology of myeloid malignancies. Complement deficiencies are primary immunodeficiencies that cause an array of clinical outcomes including an increased risk of a range of infectious as well as local or systemic inflammatory and thrombotic conditions. Here, we discuss the impact that deficiencies in complement cascade initiators, mid- and terminal-components and inhibitors have on the biology of myeloid neoplasms. The emergent conclusions indicate that the links between complement cascade, inflammatory signaling, and the homeostasis of hematopoietic system exist, and efforts should continue to detail the mechanistic involvement of complement cascade in the development and progression of myeloid cancers.
Private Woodland Owner Perceptions of Threat and Efficacy Shape Management Responses for Climate Change Adaptation
Authors: Breigenzer Peter , Leahy Jessica , Rogers Nicole Suzanne , Wason Jay W 
Published: June 2024

Abstract
Private woodland owners (PWOs) face an increasing number of considerations for climate change adaptation and mitigation activities in their forest management. Evidence suggests there may be a disconnect between PWOs’ climate change perceptions and behaviors, which can limit implementation. We conducted seventeen semistructured interviews in Maine to develop a typological framework of PWOs based on their perceptions of climate-induced threats and efficacy. Our results produced three types of PWOs: the steady-as-they-go landowner (low perceived threat), the science-driven landowner (high perceived threat; high efficacy), and the seeking-support landowner (high perceived threat; low efficacy). Although all three types of PWOs regularly implemented resistance and resilience practices, their attitudes toward transition practices (i.e., assisted migration) diverged based on their perceptions of threat and efficacy. This typological framework can be used when targeting communications to PWOs regarding the overlap between climate adaptive management and traditional best management practices.
Study Implications: PWOs in our study recognized climate-related impacts while implementing diverse forest management practices to meet both climate-related and non-climate-related objectives. The divergent attitudes toward transition practices exhibited by our three PWO types highlight the notion that adaptive practices can be both intentional and incidental. Our findings suggest that outreach efforts should understand PWO perceptions of climate change threats and their feelings of efficacy in responding to such threats. When combined with knowledge about the overlap between traditional best management practices and new climate-adaptive strategies, extension and outreach efforts can tailor their messaging to fit the appropriate audience.
Bats monitoring: a classification procedure of bats behaviours based on Hawkes processes
Authors: Denis Christophe , Dion-Blanc Charlotte , Lacoste Romain E , Sansonnet Laure , Bas Yves 
Published: June 2024

Abstract
We are interested in the problem of classifying commuting and foraging behaviour of bats at delimited geographical areas, namely sites, throughout France. To predict the majority behaviour on these sites, we use echolocation call data recorded as part of Vigie-Chiro participatory project. As the temporal distribution of calls is a relevant indicator of behaviour, providing an adequate model of this distribution is a matter of great interest. Given the self-exciting dynamics observed in foraging behaviour, we propose to model bat calls by Hawkes processes. Specifically, we consider that the start time of each call emitted on a site is an event of a Hawkes process. Taking advantage of this modelling, we use a suitable procedure that relies on the empirical risk minimization principle to discriminate between the 2 classes. Then, the performance of the procedure is assessed on synthetic data through comprehensive numerical experiments. The overall methodology is evaluated with a goodness-of-fit test. Finally, we present the obtained results on the real data set. The classification results are convincing and show the relevance of our method, which could contribute to a better understanding of behavioural determinants and open up broad perspectives in spatial ecology.
Role of methylene blue with fibrin glue in branchial cleft anomaly case report and review of literature
Authors: Alsudays Ali M , Almutairi Homood Mohammad , Almutairi Abdulrahman N , Alenezi Mazyad M , AlShiha Wala S 
Published: June 2024

Abstract
We report a 3-year-old girl who presented to our clinic with a left-sided neck mass at the junction of the middle and lower thirds of the anterior border of the sternocleidomastoid with a slight tenderness. The patient was then diagnosed with a branchial cleft and was taken for surgical excision. Intraoperatively, we injected methylene blue with fibrin glue using an arterial catheter inside the tract, which facilitated the dissection of the tract.
Endometriosis presenting as a perianal abscess: case report
Authors: Kim Jieun , Yun Jung-A , Youn Sangmin , Park Mi-Ok 
Published: June 2024

Abstract
Endometriosis is common benign disorder characterized by the presence of endometrial glands and stroma outside the uterine cavity. Endometriosis of perianal region is a rare condition. We report a case of perianal endometriosis presenting initially as a perianal abscess. Transperineal ultrasound showed a 1.5 cm size irregular mixed echogenicity lesion without involving anal sphincters. Complete surgical excision was performed. The histopathological examination confirmed as endometriosis.
Nanoporous Gold Thin Films as Substrates to Analyze Liquids by Cryo-atom Probe Tomography
Authors: Woods Eric V , Saksena Aparna , El-Zoka Ayman A , Stephenson Leigh T , Schwarz Tim M , Singh Mahander P , Aota Leonardo S , Kim Se-Ho , Schneider Jochen , Gault Baptiste 
Published: June 2024

Abstract
Cryogenic atom probe tomography (cryo-APT) is being developed to enable nanoscale compositional analyses of frozen liquids. Yet, the availability of readily available substrates that allow for the fixation of liquids while providing sufficient strength to their interface is still an issue. Here, we propose the use of 1–2-µm-thick binary alloy film of gold–silver sputtered onto flat silicon, with sufficient adhesion without an additional layer. Through chemical dealloying, we successfully fabricate a nanoporous substrate, with an open-pore structure, which is mounted on a microarray of Si posts by lift-out in the focused-ion beam system, allowing for cryogenic fixation of liquids. We present cryo-APT results obtained after cryogenic sharpening, vacuum cryo-transfer, and analysis of pure water on the top and inside the nanoporous film. We demonstrate that this new substrate has the requisite characteristics for facilitating cryo-APT of frozen liquids, with a relatively lower volume of precious metals. This complete workflow represents an improved approach for frozen liquid analysis, from preparation of the films to the successful fixation of the liquid in the porous network, to cryo-APT.
Expression Patterns of Grainyhead-Like 2 and Ovo-Like 2 in Mouse Mammary Gland Development During Pregnancy, Lactation, and Weaning
Authors: Elfeky Mohamed , Matsuoka Shinya , Yamamoto Izumi , Elewa Yaser Hosny Ali , Nakamura Kazuki , Suzuki Hiroyoshi , Kamikawa Akihiro , Okamatu-Ogura Yuko , Kimura Kazuhiro 
Published: June 2024

Abstract
Grainyhead-like 2 (Grhl2) is a transcription factor that regulates cell adhesion genes in mammary ductal development and serves as a repressor of the epithelial–mesenchymal transition. Conversely, Ovo-like2 (Ovol2) is a target gene of Grhl2 but functions as a substitute in Grhl2-deficient mice, facilitating successful epithelial barrier formation and lumen expansion in kidney-collecting ductal epithelial cells. Our objective was to examine the expression patterns of Grhl2, Ovol2, and their associated genes during the intricate phases of mouse mammary gland development. The mRNA expression of Grhl2 and Ovol2 increased after pregnancy. We observed Grhl2 protein presence in the epithelial cell's region, coinciding with acini formation, and its signal significantly correlated with E-cadherin (Cdh1) expression. However, Ovol2 was present in the epithelial region without a correlation with Cdh1. Similarly, Zeb1, a mesenchymal transcription factor, showed Cdh1-independent expression. Subsequently, we explored the interaction between Rab25, a small G protein, and Grhl2/Ovol2. The expressions of Grhl2 and Ovol2 exhibited a strong correlation with Rab25 and claudin-4, a tight junction protein. These findings suggest that Grhl2 and Ovol2 may collaborate to regulate genes associated with cell adhesion and are crucial for maintaining epithelial integrity during the different phases of mammary gland development.
Comparative Trends in the Distribution of Prostate Cancer Stage at Diagnosis in the Department of Defense Cancer Registry and the Surveillance, Epidemiology, and End Results Data, 2004-2014
Authors: Bandi Luke L , Lin Jie , Shriver Craig D , Chesnut Gregory T , Zhu Kangmin 
Published: June 2024

ABSTRACT

Introduction
It has been demonstrated that there was an increase in later-stage prostate cancer (PCa) at diagnosis after the U.S. Preventive Services Task Force recommended against prostate-specific antigen screening for prostate cancer. However, the cancer characteristics at diagnosis within the equal-access Military Health System (MHS) during the period have not been described. In this study, we compared PCa stage at diagnosis and its trends between the military health care system and the general public and further compared the trends in tumor stage by race.

Materials and Methods
This study was based on nonidentifiable data from the U.S. Department of Defense’s Central Cancer Registry (CCR) and the Surveillance, Epidemiology, and End Results (SEER) program of the National Cancer Institute. Patients diagnosed between 2004 and 2014 were included. The distributions of PCa stage at diagnosis over time were compared between the 2 populations. Comparisons were further conducted for White and Black patients, respectively.

Results
Among the 11,895 patients in the CCR and 544,142 patients in SEER, the majority of patients were diagnosed with stage I or II prostate cancer. However, the CCR had a larger proportion of early-stage tumors (stages I and II combined) with 84.3% vs. 80.0% of SEER patients. The proportion of late-stage tumors (stages III and IV combined) increased over time from 2008 for both populations and the proportion of early-stage tumors decreased for the general population. In terms of temporal distributions by race, the trends were the same between White and Black groups in the general population. In the MHS, the trends in the White patients were similar to those in the general population, but in the Black patients, the percentages of stages I and II at diagnosis continued to increase and those of stages III and IV decreased, differing from those in the general population.

Conclusions
The MHS consistently diagnosed PCa at an earlier stage than the U.S. general population across all time periods evaluated in this study. Although similar trends were observed for White patients between both populations, the proportion of stages I and II at diagnosis increased from 2012 among Black patients in the MHS, which stands in sharp contrast to trends in the U.S. general population. Although the differences between the two populations may be associated with various factors, differences in accessibility to care and thus the use of prostate-specific antigen testing might play an important role.
Exploring Combat Tourniquet Application Errors and Duration Among Skilled and Novice Medical Trainees
Authors: Drahos Bradley A , Schwieters Katelyn R , Craig Curtis M , Norfleet Jack E , Mazzeo Mark V , Morris Nichole L 
Published: June 2024

ABSTRACT

Introduction
The use of tourniquets in combat medicine continues to be a key focus as they have consistently been shown to combat one of the leading causes of preventable death on the battlefield, massive hemorrhage to extremities. The present study analyzed tourniquet application among combat medics (68W) and combat lifesavers (CLSs) in a training environment to determine whether trainees’ performance is consistent among one another and whether performance can be associated with participant demographics such as experience or role.

Materials and Methods
Study participants treated male and female patient simulators within a tactical field care phase, both of which experienced an amputated leg and required the application of a Combat Application Tourniquet (CAT). To assess tourniquet application variability and performance, a series of application subtasks and potential errors were measured via video coding of the scenarios by a team of 5 coders. Time to tourniquet application and tourniquet application duration were also coded to assess correlations between application duration and variability or performance.

Results
Results from analyzing tourniquet application subtasks and errors through a series of one-way ANOVA tests showed that application of the CAT first, hasty CAT application, and high tourniquet application were not predictive of participant role, time within the role, and self-reported tourniquet skill, confidence, or experience. Such demographic variables were also not predictive of successful tourniquet application as defined by the number of windlass rod rotations. Results from binomial logistic regressions showed that participant role and self-reported tourniquet skill and experience were predictors of tourniquet application duration.

Conclusion
The findings suggest that high variability in CAT application methodology and performance exists among CLS and combat medics, which is largely not predictable by various demographics such as role, experience within the designated role, and self-reported confidence, skill, or experience. The observed disconnect between training or experience and CAT application performance suggests substantial variability in the consistency of training for both CLS and 68W soldiers. These inconsistencies may stem from variability in instructor knowledge, teaching styles, or training materials or may be developed through informal methods such as experiences in the field or recommendations from colleagues and experts. These findings highlight a potential need to reassess CAT application training, particularly in regard to consistency and validation. Finally, it should be noted that the study’s findings may be limited or fail to capture some study effects because of the sample size and wide range of reported experience among participants.