bluuebunny/crossref_metadata_2025_split huggingface dataset:
Telangiectasia hemorrágica hereditaria como causa de anemia ferropénica grave de origen oscuro
Authors: Pinto Angarita Jean , García del Risco Fernando , Puello Ramos Walter 
Published: February 2025

Introducción: la telangiectasia hemorrágica hereditaria o enfermedad de Osler-Weber-Rendu es una entidad autosómica dominante rara, con una frecuencia que oscila entre 1 por cada 5000 habitantes a 1 por cada 1331 dependiendo de la población y localización geográfica. Se caracteriza clínicamente por telangiectasias, epistaxis a repetición, lesiones viscerales vasculares como angioectasias y MAVs (malformaciones arteriovenosas). El diagnóstico se sospecha con tres de los 4 criterios de Curazao y se confirma con estudios genéticos y complementarios. El tratamiento para las angioectasias es el Argón plasma y para la MAV tratamiento médico con bevacizumab, embolización o resección quirúrgica y en última instancia trasplante hepático. El pronóstico es favorable si las complicaciones son diagnosticadas y tratadas a tiempo. Caso clínico: se presenta el caso de una paciente de 51 años de edad que se presentó con astenia y adinamia en la que se documentó telangiectasias en lengua, labios y dedos y se llegó al diagnóstico de telangiectasia hemorrágica hereditaria luego de la confirmación de malformación arteriovenosa hepática y telangiectasias gástricas. Con base en este caso clínico y la pertinente revisión de la literatura, se propone un enfoque diagnóstico y terapéutico como parte del abordaje de esta enfermedad. Conclusión: la telangiectasia hemorrágica hereditaria al ser una enfermedad rara con una alta carga de morbilidad, la cual puede llegar a ser un reto diagnóstico llegando a representar una causa de anemia severa de origen gastrointestinal.
Enhancing Decision-making in Uncertain Domains through Optimized Fuzzy Logic Systems
Authors: Sekhi Ihab , Kovács Szilveszter , Nehéz Károly 
Published: February 2025

Fuzzy logic helps manage human-like reasoning in system control, mainly when traditional analysis does not work due to complex control processes. Despite its usefulness, fuzzy logic faces challenges in decision-making, especially in complex business situations and when combined with expert systems. It struggles with uncertainty and relies on various beliefs and assumptions, which is limiting compared to other methods for handling uncertainty. However, fuzzy logic can improve traditional control systems by adding a layer of intelligence. This study adapts mathematical functions like the straight-line point-slope equation, the absolute value function, and the Gaussian equation to develop accurate and flexible membership functions for fuzzy logic systems. By analyzing 10,000 tasks of different sizes, we found our methods significantly more precise than traditional approaches, especially in determining degrees of membership for uncertain and complex environments. Our MATLAB research shows the potential of using varied membership functions to enhance fuzzy logic systems' accuracy and flexibility.
Systematic Literature Review: Dampak Perilaku Seksual Berisiko terhadap Kejadian HIV/AIDS pada Kelompok Lelaki Seks dengan Lelaki
Authors: Alia Syafina Dwi Putri , Zahida Raissa Amira , Nurhaliza Dhia Azhar , Maulida Syakira Auly , Herbawani Chahya Kharin 
Published: February 2025

Perilaku seksual berisiko yang dilakukan oleh kelompok homoseksual karena sering berganti pasangan dan berhubungan seksual secara anal maupun oral tanpa kondom merupakan faktor risiko yang dapat berkontribusi terhadap penularan infeksi HIV/AIDS di kelompok laki-laki melakukan hubungan seks sesama gender (LSL). Artikel ini bertujuan untuk membahas terkait dampak perilaku seksual berisiko serta strategi pencegahan dan penanganan kejadian infeksi HIV/AIDS akibat hubungan perilaku seks berisiko pada kelompok LSL. Metode penelitian dari artikel ini adalah Systematic Literature Review dengan menggunakan database Google Scholar, Science Direct dan PubMed sesuai dengan PECO serta menggunakan Newcastle Ottawa Scale (NOS) untuk menilai risiko bias. Rentang waktu artikel studi kuantitatif observasional yang dipilih mulai dari tahun 2021–2024 dalam Bahasa Inggris dan Bahasa Indonesia serta memuat kata kunci Perilaku Seksual Berisiko, HIV/AIDS, dan LSL dalam Bahasa Indonesia dan memuat kata kunci Sexual Risk Behaviour, HIV/AIDS, dan MSM dalam Bahasa Inggris yang terdapat naskah lengkap. Artikel diseleksi menggunakan kriteria inklusi dan eksklusi sesuai standar berlaku sehingga diperoleh 10 artikel yang menyatakan perilaku seksual berisiko tanpa pengaman seperti sering berganti pasangan seksual, melakukan hubungan seks anal serta oral tanpa kondom berdampak signifikan terhadap kejadian HIV/AIDS pada kelompok LSL. Oleh sebab itu, diperlukan strategi guna meminimalisir risiko penyebaran infeksi HIV/AIDS untuk kelompok LSL meliputi promosi penggunaan PrEP, penggunaan kondom secara konsisten, tes HIV rutin, intervensi perilaku melalui konseling dan pendidikan, keterlibatan dengan komunitas LSL, serta mengatasi hambatan struktural seperti stigma dan diskriminasi.
Kesetaraan Gender untuk Menghadirkan “Ordinary People” dalam Narasi Buku Teks Sejarah SMA
Authors: Setiawati Debi , Fatmawati Fatmawati , Kurniawan Faisal 
Published: February 2025

Analisis kritis terhadap dinamika historiografi dalam buku teks sejarah Indonesia menunjukkan pergeseran signifikan dari era Orde Baru ke masa Reformasi. Pada masa Reformasi membawa revisi dan dekonstruksi narasi-narasi mengarah pada representasi sejarah yang lebih beragam dan inklusif, yang disesuaikan dengan kebutuhan sosial dan politik yang berubah. Untuk itu narasi berupa kesetaraan gender dengan menghadirkan tokoh – tokoh perempuan dari kelompok bawah dalam sejarah dengan menampilkan ordinary people dapat menambah wawasan siswa menjadi lebih luas. Metode yang digunakan berupa analisis deskriptif dengan pendekatan content Literatur. Sumber pustaka yang digunakan berupa buku, jurnal dan prosiding yang dianalisis dengan menggunakan pendekatan multidimensional. Pengembangan buku teks sejarah yang berfokus pada masyarakat awam dan berperspektif gender dapat meningkatkan literasi sejarah dengan menumbuhkan kemampuan berpikir kritis, empati, dan pemahaman yang lebih mendalam terhadap proses sejarah. Hal ini dapat mendorong siswa dapat memahami narasi dari berbagai perspektif yang berbeda, dan mengenali peran individu serta kelompok dalam membentuk sejarah, sehingga dapat menjadikan pembelajaran sejarah lebih relevan dan menarik
PKM KELOMPOK USIA REMAJA DALAM PENCEGAHAN DINI DAN MENURUNKAN RESIKO REMAJA DENGAN ADIKSI INTERNET DI PERSAUDARAAN SETIA HATI TERATE RANTING TUGU SEMARANG
Authors: Tsania Novia Putri , Sulistyowati Indah 
Published: February 2025

Pandemi covid-19 meningkatkan penggunaan internet. Remaja memiliki resiko efek negatif internet. Kondisi di lokasi kegiatan atau mitra menunjukkan adanya adiksi internet, salah satu faktornya yaitu karena internet sudah menjadi kebutuhan sehari-hari. Internet digunakan pada saat pembelajaran maupun istirahat. MR Spectroscopy Imaging brain dapat menunjukkan spektral dari metabolit tubuh. Tujuan pemeriksaan MR Spectroscopy diharapkan dapat digunakan sebagai alat penunjang diagnostik untuk pencegahan dini dan menurunkan resiko remaja menjadi adiksi internet dengan mengurangi pemakaian internet dalam kehidupan sehari-hari, setelah mengetahui hasil dari nilai metabolit yang berubah menggunakan MR Spectroscopy. Metode yang digunakan dalam pengabdian masyarakat ini yaitu dengan memberikan pre test dan post test, pemberian materi dan penyuluhan, diskusi dan tanya jawab serta melakukan evaluasi dan monitoring. Hasil dari pelaksanaan kegiatan pengabdian kepada masyarakat yang dilaksanakan pada Minggu, 22 Januari 2023 yang berlokasi di SMK Bina Nusantara Semarang menunjukkan remaja telah memahami resiko remaja dengan adiksi internet dan bagaimana cara pencegahan dan menurunkan adiksi internetnya. Hal ini dapat dilihat dari hasil pre test hampir semua remaja belum mengerti bahaya adiksi internet. Setelah diberikan materi mengenai resiko remaja dengan adiksi internet dan dilakukan post test pada remaja mereka mulai paham dan dapat menjawab pertanyaan dari penyaji mengenia resiko dari adiksi internet pada remaja.
DETEKSI KELAINAN ORGAN REPRODUKSI WANITA YANG MEMPENGARUHI INFERTILITAS DAN PEMERIKSAANYA, SERTA HAK PASIEN BERDASARKAN PERMENKES No 04 TAHUN 2018
Authors: Jamil Masfufatun , Suraningsih Nanik , Rosidah Siti 
Published: February 2025

Angka infertil di seluruh dunia terhitung cukup besar. Berdasarkan data, terdapat 1712 pria dan 2055 wanita yang mengalami infertilitas. Jumlah pasangan infertil sebanyak 36% diakibatkan kelainan pada pria, sedangkan 64% pada wanita. Hasil penelitian menunjukkan kejadian infertilitas pada wanita 15% terjadi pada usia 30-34 tahun dan meningkat 30% pada usia 35-39 tahun. Untuk mendeteksi dini kelainan organ reproduksi wanita yang dapat mempengaruhi infertilitas dianjurkan untuk memeriksakan diri ke RS(RS). Permenkes No 04 tahun 2018 Pasal 17, menyebutkan bahwa Hak Pasien di RS meliputi: memperoleh informasi tentang hak dan kewajiban Pasien; memperoleh layanan yang manusiawi, adil, jujur, dan tanpa diskriminasi; mendapatkan kerahasiaan penyakit yang diderita; dst. Untuk itu, dilakukan penguatan kemandirian masyarakat dalam mendeteksi kelainan organ reproduksi wanita yang mempengaruhi infertilitas pada ibu PKK usia reproduksi di RT/RW 03/04 Kelurahan Salamanmloyo Kecamatan Semarang Barat. Metode yang digunakan yaitu pre tes, ceramah, demonstrasi, diskusi dan tanya jawab serta evaluasi. Hasil yang didapat diantaranya: dilakukan pre tes, pengetahuan responden sebagian besar cukup (71%) dan setelah dilakukan post tes pengetahuan meningkat menjadi baik (81%), mitra konsisten dapat melakukan palpasi pada abdomen (tanda kelainan organ reproduksi yang dapat menyebabkan infertilitas), memiliki kesadaran untuk pemeriksaan dini serta mengerti akan hak pasien di RS.
EDUKASI PENGENALAN DAN PENCEGAHAN OSTEOARTHRITIS PADA MASYARAKAT KABUPATEN SEMARANG PROVINSI JAWA TENGAH
Authors: Alfiani Novita , Restyanti W U Lucky 
Published: February 2025

Osteoarthritis adalah penyakit degeneratif yang biasa dijumpai pada orang lanjut usia dan bisa juga terjadi pada usia yang lebih muda. Pada penderita osteoarthritis kerap merasakan rasa nyeri dan menyebabkan disabilitas, sehingga hal ini mengakibatkan aktivitas sehari-hari menjadi terganggu. Saat ini tren penduduk yang mengalami obesitas meningkat, termasuk di Kelurahan Bandarjo Kecamatan Ungaran Barat Kabupaten Semarang. Hal tersebut menyebabkan rentan terjadinya kasus osteoarthritis lutut dan kemungkinan besar akan meningkat secara substansial di tahun-tahun yang akan datang. Untuk mencegah terjadinya hal tersebut, maka masyarakat di wilayah Bandarjo perlu mendapatkan edukasi tentang osteoarthritis dan upaya pencegahannya. Program pengabdian masyarakat dengan judul Edukasi Pengenalan Dan Pencegahan Osteoarthritis Di Kelurahan Bandarjo Kecamatan Ungaran Barat Kabupaten semarang ini mempunyai beberapa tujuan yang ingin dicapai, yaitu, meningkatkan pengetahuan tentang osteoarthritis dan pencegahannya. Dengan kegiatan ini diharapkan kejadian osteoarthritis dapat dicegah atau diturunkan angka kejadiannya sehingga masyarakat dapat lebih produktif berkegiatan tanpa terhalang kejadian osteoarthritis. Metode yang digunakan pada kegiatan ini adalah dengan mengadakan sosialisasi tentang osteoarthritis dan pencegahannya di wilayah yang dijadikan mitra dalam kegiatan pengabdian ini dengan memberikan penjelasan terkait data yang dibutuhkan pada saat pre test dan pemberian video contoh latihan. Formulir pre test yang terkumpul dalam kegiatan ini adalah 45 forrmulir dari 45 responden. Karakteristik subyek yaitu usia, jenis kelamin, pekerjaan, tingkat nyeri dan lama menderita nyeri. Peserta kegiatan mendapatkan edukasi berupa cara beraktifitas sehari hari untuk mencegah nyeri dan berkembangnya penyakit lebih lanjut. Kesimpulan dari evaluasi yang dilakukan bahwa semua peserta dapat mengerti dan memahami latihan yang diberikan.
Design of novel graded bone scaffolds based on triply periodic minimal surfaces with multi-functional pores
Authors: Lai Rongwu , Jiang Jian , Huo Yi , Wang Hao , Bosiakov Sergei , Lyu Yongtao , Li Lei 
Published: February 2025

BackgroundVarious mechanical and biological requirements on bone scaffolds were proposed due to the clinical demands of human bone implants, which remains a challenge when designing appropriate bone scaffolds.MethodsIn this study, novel bone scaffolds were developed by introducing graded multi-functional pores onto Triply Periodic Minimal Surface (TPMS) structures through topology optimization of unit cell. The performance of these scaffolds was evaluated using finite element (FE) analysis and computational fluid dynamics (CFD) method.ResultsThe results from FE analysis indicated that the novel scaffold exhibited a lower elastic modulus, potentially mitigating the issue of stress shielding. Additionally, the results from CFD demonstrated that the mass transport capacity of the novel scaffold was significantly improved compared to conventional TPMS scaffolds.ConclusionIn summary, the novel TPMS scaffolds with graded multi-functional pores presented in this paper exhibited enhanced mechanical properties and mass transport capacity, making them ideal candidates for bone repair. A new design framework was provided for the development of high-performance bone scaffolds.
Surveillance of SARS-CoV-2 variants in Henan, China from 2023 to 2024
Authors: Song Yun , Wu Bicong , Ma Hongxia , Li Yafei , Yan Su , Pan Jingjing , Wang Haifeng , Ye Ying , Huang Xueyong , Guo Wanshen 
Published: February 2025

ObjectiveIn January 2023, China implemented the “Class B Management” policy, marking a new phase in COVID-19 control. As new SARS-CoV-2 variants continue to emerge, some have shown significant immune evasion, posing challenges to epidemic control efforts. To manage the pandemic effectively, Henan Province launched a surveillance program for SARS-CoV-2 variants, systematically analyzing their clinical characteristics and epidemiological patterns.MethodsThis study collected genomic sequence data from 5,965 COVID-19 cases between January 1, 2023, and March 17, 2024, using the Henan Province SARS-CoV-2 variant surveillance system. Genome sequence analysis was performed with CLC Genomics Workbench, and genotyping and sequence alignment were carried out using the Nextclade platform. The clinical severity of different variants was assessed in relation to patient sex, age, clinical classification, and vaccination status.ResultsBetween Week 1 of 2023 and Week 11 of 2024, a total of 5,965 complete SARS-CoV-2 genome sequences were obtained, including 3,004 male (50.36%) and 2,961 female (49.64%) cases. The majority of cases were mild (5,451 cases, 91.38%), followed by moderate (311 cases, 5.21%) and severe or critical cases (203 cases, 3.4%). The predominant variants included BA.5.2, XBB, and BA.2.86. BA.5.2 was dominant until April 2023, after which it was gradually replaced by XBB. From December 2023, BA.2.86 began to increase and became the predominant variant by January 2024. The XBB variant exhibited a significantly lower rate of severe cases, with most infections being mild (P &lt; 0.05). Male patients, the elderly, and certain variants (e.g., BA.5.2) were associated with more severe outcomes, while XBB and BA.2.86 showed lower pathogenicity, with a marked reduction in severe and fatal cases (P &lt; 0.05).ConclusionAs SARS-CoV-2 variants evolve, the incidence of severe cases has progressively decreased. Both XBB and BA.2.86 variants exhibit lower pathogenicity. This study provides vital scientific evidence on the epidemiological features, clinical manifestations, and control strategies of SARS-CoV-2 variants. It underscores the importance of continuous viral surveillance and genomic sequencing to guide public health decision-making.
OBDT-theta, a multi-channel TDC and readout board for the CMS muon drift tubes in HL-LHC
Authors: Bedoya C. F. , Cuadrado S. , Cuchillo J. , Eliseev D. , Esper N. , Francia D. , Navarro A. , Paz R. , Presser C. , Redondo I. , Redondo D. D. , Sastre J. 
Published: February 2025

A new readout board for the digitization of the CMS (Compact Muon Solenoid) Muon Drift Tube (DT) chambers has been designed in order to cope with the increase of occupancy and trigger rates expected during operation under the foreseen luminosity in the HL-LHC (High Luminosity Large Hadron Collider). The board OBDT-theta (On-detector Board for Drift Tubes) can perform the time digitization and readout of the DT chamber signals measuring the z-coordinate (along the beam axis) of CMS. A total of 228 channels can be digitized with a time bin of 0.78 ns and full streaming of all the DT chamber signals can be made through optical links into the CMS counting room. There, the full detector information can be available to perform the trigger and event building logic. The different functionality of the OBDT-theta board has been verified and the overall architecture has been validated through specific tests. The OBDT-theta architecture and main functionality will be presented in this contribution, showing the suitability of the design for the expected functionality during the HL-LHC.
Engagement factors affect academic success through study approaches among physical education and sport university students: a mediation analysis
Authors: Tannoubi Amayra , Bonsaksen Tore , Mørk Gry , Ahmedov Farruh , Setiawan Edi , Azaiez Fairouz 
Published: February 2025

IntroductionUniversity students should engage with the study and ensure they adopt productive study approaches, but the nature of relationships between engagement and study approaches are under-researched. The study aimed to investigate how emotional, cognitive, and behavioral engagement affect academic success through study approaches among physical education and sports students.MethodsOnline forms were submitted by 488 students in physical education and sports (age range 19–25 years, Mean = 21 ± 1.5 year). They completed surveys regarding their academic engagement, study approaches, and grade point average (GPA). Analyses of associations were conducted through linear regression analysis and mediation analysis.ResultsResults from the linear regression analysis showed correlations between academic engagement factors, study approach variables, and GPA, with higher GPA correlating with higher scores on behavioral engagement, cognitive engagement, surface theory task, and deep theory task, and with lower scores on surface practical task. The analysis of total and direct effects revealed positive associations between all academic engagement factors and GPA. Emotional engagement exhibited a positive association with GPA mediated by study approaches. All engagement dimensions appear to influence academic success among these students.ConclusionThe influence of emotional engagement on academic success appears in part to be operating through its effects on study approaches. The study can enable educators in monitoring and enhancing student engagement, thereby supporting students in their pursuit of high academic performance in physical education and sport.
Electrochemotherapy with bleomycin, oxaliplatin, or cisplatin in mouse tumor models, from tumor ablation to in situ vaccination
Authors: Uršič Valentinuzzi Katja , Kamenšek Urška , Kranjc Brezar Simona , Heranney Chloe , Komel Tilen , Buček Simon , Čemažar Maja , Serša Gregor 
Published: February 2025

IntroductionIn addition to its direct cytotoxic effects, ablative therapies as electrochemotherapy (ECT) can elicit indirect antitumor effects by triggering immune system responses. Here, we comprehensively analyzed this dual effectiveness of intratumoral ECT with chemotherapeutic drugs bleomycin (BLM), oxaliplatin (OXA), and cisplatin (CDDP). Our aim was to determine if ECT can act as in situ vaccination and thereby induce an abscopal effect. By evaluating ECT’s potential for in situ vaccination, our goal was to pave the way for future advancements for its combination with emerging (immuno)therapies, leading to enhanced responses and outcomes.MethodsWe employed two mouse tumor models, the immunologically cold B16F10 melanoma and 4T1 mammary carcinoma, to explore both local and systemic (i.e., abscopal) antitumor effects following equieffective intratumoral ECT with BLM, OXA, and CDDP. Through histological analyses and the use of immunodeficient and metastatic (for abscopal effect) mouse models, we identified and compared both the cytotoxic and immunological components of ECT’s antitumor efficiency, such as immunologically recognizable cell deaths (immunogenic cell death and necrosis) and immune infiltrate (CD11+, CD4+, CD8+, GrB+).ResultsDifferences in immunological involvement after equieffective intratumoral ECT were highlighted by variable kinetics of immunologically recognizable cell deaths and immune infiltrate across the studied tumor models. Particularly, the 4T1 tumor model exhibited a more pronounced involvement of the immune component compared to the B16F10 tumor model. Variances in the antitumor (immune) response were also detected based on the chemotherapeutic drug used in ECT. Collectively, ECT demonstrated effectiveness in inducing in situ vaccination in both tumor models; however, an abscopal effect was observed in the 4T1 tumor model only.ConclusionsThis is the first preclinical study systematically comparing the immune involvement in intratumoral ECT’s efficiency using three distinct chemotherapeutic drugs in mouse tumor models. The demonstrated variability in immune response to ECT across different tumor models and chemotherapeutic drugs provides a basis for future investigations aimed at enhancing the effectiveness of combined treatments.
Associations between asthma and Life’s Essential 8: a cross-sectional study
Authors: Xu Jiao , Tang Jianlei 
Published: February 2025

BackgroundAsthma is a serious respiratory disease attributed to multiple factors. The Life’s Essential 8 (LE8), introduced by the American Heart Association, aims to improve and maintain cardiovascular health. However, the correlation between LE8 components and asthma remains unclear. We hypothesized that LE8 is a protective factor against asthma.Materials and methodsMultiple logistic regression analysis, restricted cubic spline (RCS) analysis, and subgroup analysis were used to analyze the data collected from the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2018.ResultsA total of 3,360 participants with asthma were included in the analysis. With all confounders controlled for, LE8 scores were negatively correlated with asthma prevalence (odds ratio (OR) per 10-point increment, 0.85 [95% confidence interval (CI), 0.82–0.88]). Compared to low LE8 scores, moderate and high LE8 scores were associated with reduced asthma risk, with adjusted ORs (95% CIs) of 0.59 (0.51–0.68) and 0.48 (0.39–0.58), respectively. Non-linear correlations were observed between LE8 scores and asthma (p non-linear = 0.01) and between health factor scores and asthma (p non-linear = 0.01). However, a linear dose–response correlation was noted between health behavior scores and asthma (p non-linear = 0.30). Subgroup analysis showed no significant interaction effects (p &gt; 0.05), except in the sex and drinking status subgroups (p for interaction = 0.02).ConclusionAsthma is associated with components of LE8, which warrants further attention and may contribute to reducing asthma prevalence.