bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations of diagnostic awareness with psychosocial symptoms and survival time in patients with advanced lung cancer
Authors: Abali Hulya , Onur Seda Tural , Baser Yusuf , Demir Dilara , Bicen Aslı 
Published: May 2024

Abstract

Background
Disclosing diagnosis to lung cancer patients is a critical issue. The psychosocial consequences of diagnostic awareness and its impact on life expectancy are issues of curiosity. We intended to evaluate the effects of diagnostic awareness on psychosocial symptomatology and survival time in advanced lung cancer patients.
Methods
This prospective cohort study was conducted on 126 advanced lung cancer patients admitted to the oncology department between Feb 2016 and Aug 2021. A face-to-face survey, including questions on age, gender, marital/employment statuses, comorbidities, and symptom checklist (SCL-90-R) assessment, was applied to patients. Diagnostic awareness was recorded by asking patients about comorbidities and obtaining confirmation from their relatives. Survival data was collected from the national death notification system on Feb 2023, and survival time was calculated from admission until Feb 2023.
Results
Of the patients, 104 were males, and 86 were non-survivors. Survival time and scores of SCL-90-R subscale dimensions were compared between diagnosis-aware (79.4%) and diagnosis-unaware groups (20.6%). Somatization, depression, psychoticism, additional scales, general symptoms, Positive Symptom Total, and Positive Symptom Distress Index scores were significantly higher in the diagnosis-unaware group (p=0.00, p=0.01, p=0.01, p=0.00, p=0.01, p=0.02, p=0.01, respectively). No significant associations were found between survival time and diagnostic awareness, gender, and marital/employment statuses.
Conclusions
Advanced lung cancer patients aware of such a serious disease experienced less psychosocial burden. However, no significant difference was found in survival time between diagnosis-aware and diagnosis-unaware patients. The diagnosis should be disclosed to lung cancer patients after the confirmation of diagnosis.
Laboratory validation of a clinical metagenomic next-generation sequencing assay for respiratory virus detection and discovery
Authors: Chiu Charles , Tan Jessica , Servellita Venice , Stryke Doug , Kelly Emily , Streithorst Jessica , Sumimoto Nanami , Foresythe Abiodun , Huh Hee Jae , Nguyen Jenny , Oseguera Miriam , Brazer Noah , Tang Jack , Ingebrigsten Danielle , Fung Becky , Reyes Helen , Hillberg Melissa , Chen Alice , Guevara Hugo , Yagi Shigeo , Morales Christina , Wadford Debra , Mourani Peter , Langelier Charles , de Lorenzi-Tognon Mikaël , Benoit Patrick 
Published: May 2024

Abstract

Tools for rapid identification of novel and/or emerging viruses are urgently needed for clinical diagnosis of unexplained infections and pandemic preparedness. Here we developed and clinically validated a largely automated metagenomic next-generation sequencing (mNGS) assay for agnostic detection of respiratory viral pathogens from upper respiratory swab and bronchoalveolar lavage samples in <24 hours. The mNGS assay achieved mean limits of detection of 543 copies/mL, viral load quantification with 100% linearity, and 93.6% sensitivity, 93.8% specificity, and 93.7% accuracy compared to gold-standard clinical multiplex RT-PCR. Performance increased to 97.9% overall predictive agreement after discrepancy testing and clinical adjudication, which was superior to that of RT-PCR (95.0% overall agreement). To enable discovery of novel, sequence-divergent human viruses with pandemic potential, de novo assembly and translated nucleotide algorithms were incorporated into the automated SURPI+ computational pipeline used by the mNGS assay for pathogen detection. Using in silico analysis, we showed after removal of all human viral sequences from the reference database that 70 (100%) of 70 representative human viral pathogens could still be identified based on homology to related animal or plant viruses. Our assay, which was granted breakthrough device designation from the US Food and Drug Administration (FDA) in August of 2023, demonstrates the feasibility of routine mNGS testing in clinical and public health laboratories, thus enabling a robust and rapid response to the next viral respiratory pandemic.
Silencing HEATR1 Rescues Cisplatin Resistance of Non-small Cell Lung Cancer by Inducing Ferroptosis via the p53/SAT1/ALOX15 Axis
Authors: Ma Xing , Gan Yifan , Mai Zhongchao , Song Yanan , Zhang Miao , Xia Wei 
Published: May 2024

Background:
Cisplatin (DDP) is a commonly used chemotherapy agent. However, its
resistance to the drug is a major challenge in its clinical application. Earlier research has suggested
a connection between HEATR1 and chemoresistance in cancer. However, additional investigation
is needed to better understand its involvement in resistance to DDP. In this study, we aimed
to determine the regulatory effect of HEATR1 on the resistance of cisplatin in NSCLC.

Methods:
We collected specimens of both DDP-resistant and non-resistant NSCLC to examine
the expression of HEATR1. Additionally, we established cisplatin-resistant cells of NSCLC using
the A549 cell line. Cell ability was examined by CCK-8 assay. Cell apoptosis and lipid ROS were
examined by flow cytometry. The expressions of HEATR1, p53, SAT1, and ALOX15 were determined
by qRT-PCR and Western blot. The tumor xenograft experiment was conducted to assess
the impact of silencing HEATR1 on cisplatin resistance in vivo in NSCLC.

Results:
The expression levels of HEATR1 were found to be significantly elevated in DDP-resistant
tissues and cells of NSCLC as compared to non-resistant counterparts. Conversely, the expression
levels of p53, SAT1, and ALOX15 were observed to be reduced in DDP-resistant cells.
Through the inhibition of HEATR1, the proliferation of DDP-resistant cells was significantly suppressed,
while the generation of lipid ROS was enhanced. This effect was achieved by activating
ferroptosis and the p53/SAT1/ALOX15 pathway, as demonstrated both in vitro and in vivo. Conversely,
the overexpression of HEATR1 exhibited opposite effects. Furthermore, the silencing of
p53 and ALOX15 reversed the oncogenic effects of HEATR1 and inhibited ferroptosis in DDP-resistant
NSCLC cells, suggesting the involvement of p53 and ALOX15 in HEATR1-mediated
DDP resistance.

Conclusion:
Finally, the findings revealed that HEATR1 silencing reduced DDP resistance in NSCLC
by inducing ferroptosis via the p53/SAT1/ALOX15 axis. HEATR1 might become a potential
target for overcoming DDP resistance in NSCLC treatment.
Effects of Psychological Stress on Multiple Sclerosis via HPA Axis-mediated Modulation of Natural Killer T Cell Activity
Authors: Gao Yafei , Liu Wenying , Liu Paiyu , Li Min , Ni Bing 
Published: May 2024

:
The involvement of psychological stress and Natural Killer T (NKT) cells in the pathophysiology
of multiple sclerosis has been identified in the progression of this disease. Psychological
stress can impact disease occurrence, relapse, and severity through its effects on the Hypothalamic-
Pituitary-Adrenal (HPA) axis and immune responses. NKT cells are believed to play a pivotal role
in the pathogenesis of multiple sclerosis, with recent evidence suggesting their distinct functional
alterations following activation of the HPA axis under conditions of psychological stress. This review
summarizes the associations between psychological stress, NKT cells, and multiple sclerosis
while discussing the potential mechanism for how NKT cells mediate the effects of psychological
stress on this disease.
ОРГАНІЗАЦІЯ ЗАЛУЧЕННЯ, ВИКОРИСТАННЯ ТА МОНІТОРИНГУ МІЖНАРОДНОЇ ТЕХНІЧНОЇ ДОПОМОГИ У СФЕРІ ОБОРОНИ
Authors: Свірко Світлана , Довгалюк Віта , Кучменко Віталій , Тростенюк Тетяна , Сидоренко Олексій 
Published: May 2024

У статті запропоновано запровадження поняття «міжнародна технічна допомога у сфері оборони», під якою мається на увазі військове майно, роботи та послуги, що відповідно до міжнародних договорів України надаються партнерами з розвитку на безоплатній та безповоротній основі з метою підтримки обороноздатності України; при цьому формами міжнародної технічної допомоги у сфері оборони виступають: матеріально-технічнні засоби оборонного характеру, фінансові ресурси (у тому числі гранти), нематеріальні ресурси, роботи та послуги, що призначені для потреб оборонної функції країни.
Cultura organizativa digital y coaching educativo digital en línea: un estudio de metaanálisis en el ámbito de las Ciencias Sociales
Authors: Baquerizo Álava Verónica , Fernández-Márquez Esther , Morales Cevallos María Belén , López Meneses Eloy 
Published: May 2024

Esta investigación se enmarca en el campo de la Cultura Organizacional y el coaching educativo. La cultura organizativa se instaura cada vez más en los distintos ámbitos. Vinculada a la escuela, favorece la mejora del desarrollo personal y académico de los estudiantes y docentes. El objetivo es analizar las tendencias sobre las prácticas para la mejora del rendimiento, la eficacia y el bienestar de los educadores, y cómo está mejorando el aprendizaje y el desarrollo de los estudiantes. La revisión bibliométrica de los datos se realizó a partir de las palabras clave: Organizational Culture OR Educational Coaching AND Education, limitando los registros a aquellas publicaciones categorizadas en el campo de las Ciencias Sociales. La búsqueda se realizó en inglés y se analizaron las siguientes dimensiones: tema, tipos de publicación, área temática, país, publicación, autor y año, ambas tratadas mediante estadística descriptiva. Los resultados reflejan un total de 893 documentos indexados en Ciencias Sociales. Por último, se analizó la concurrencia temática de las palabras clave mediante el software VosViewer, que agrupamos en 6 categorías principales (organización, cultura organizacional, educación, liderazgo, relaciones interprofesionales y comunicación interpersonal). Según las investigaciones actuales, la relación entre cultura organizativa y coaching educativo mejora la eficacia, bienestar y liderazgo en instituciones educativas. Entre las principales conclusiones cabe destacar la necesidad de explorar nuevas vías de colaboración a escala internacional.
Computed tomography findings of nasal cryptococcosis in Australia (2008–2020): 12 dogs and 9 cats
Authors: Wong Samantha A. , Jacobson Else , Podadera Juan , Siow Jia Wen , Woerde Dennis J. , Tebb Anna , Thompson Mary , Colins Dave , Lunn Julian , Malik Richard 
Published: May 2024

Abstract

OBJECTIVE
To describe the CT findings of Australian dogs and cats with nasal cryptococcosis over a 12-year period.

ANIMALS
12 dogs and 9 cats diagnosed with nasal cryptococcosis from 2008 through 2020.

METHODS
CT findings were compared among enrolled cases from Australian veterinary referral centers. Disease severity was compared between a subset of patients with cryptococcal speciation performed (n = 6 dogs; n = 3 cats) and geographic domicile.

RESULTS
Dogs demonstrated diffuse disease affecting numerous nasal regions and sinuses. Cats displayed more focal nasal and nasopharyngeal disease. Dogs were more likely to have a nasal mass, whereas cats were more likely to have a nasopharyngeal mass. Cribriform plate lysis was common in dogs but not observed in cats. Sinonasal osteolysis was a common feature in both species. Mandibular lymph nodes were commonly enlarged in dogs, whereas in cats, the retropharyngeal lymph nodes were more likely enlarged. There was no obvious difference in disease severity or lesion distribution in relation to the causal species of Cryptococcus, although to determine if this finding is robust, an appropriately powered prospective study is warranted.

CLINICAL RELEVANCE
There are numerous studies describing the clinical features, treatment, and outcomes of dogs and cats with cryptococcosis. To the best of our knowledge, there is only 1 previous study describing the CT features of nasal cryptococcosis, undertaken in one part of North America. Our study describes the CT features of nasal Cryptococcus sp in an Australian canine and feline cohort, adding new pertinent observations while reinforcing reported radiological observations.
Heartbeat Chronicles: Decoding the Interplay of Echocardiography and Heart Rate Variability in Chronic Heart Failure Patients – Unraveling the Mysteries with Traditional and Advanced 24-Hour Holter ECG Parameters
Authors: Duca Ştefania-Teodora , Tudorancea Ionuţ , Miftode Radu-Ştefan , Chetran Adriana , Costache Alexandru-Dan , Pavăl D. Robert , Costache-Enache Irina-Iuliana 
Published: May 2024

Abstract

Objective
Chronic heart failure (CHF) is a clinical syndrome that encompasses individuals who either have received a definitive diagnosis of heart failure or display a gradual escalation of symptoms as time elapses. Echocardiography, particularly evaluating left ventricular function, is crucial for diagnosis and prognosis. However, 24-hour Holter monitoring, focusing on heart rate variability (HRV), provides insights into autonomic dynamics and vulnerability. Recent HRV parameters offer nuanced information, enhancing risk stratification and guiding personalized interventions in CHF. The interplay between echocardiography and HRV enables a comprehensive approach, refining the management of CHF by considering both cardiac structure and autonomic regulation.

Methods
This prospective study at “St. Spiridon” County Hospital involved 80 patients with left ventricular ejection fraction (LVEF) < 50%. The diagnosis was according to standard clinical echocardiography, laboratory panel, and Holter ECG monitoring.

Results
Unexpectedly, no statistically significant relationship was found between commonly used HRV parameters and echocardiographic parameters. Further analyses showed statistically significant associations between non-traditional HRV parameters and E/A ratio, E/E’, and S’ lateral and septal. Additionally, modifications in HRV parameters were correlated with mitral valve deceleration time, left atrial volume index, estimated pulmonary artery systolic pressure, and cardiac output.

Conclusions
Less commonly used Holter ECG parameters, such as acceleration capacity, deceleration capacity, and triangular index, demonstrated significant diagnostic efficacy, especially when conventional HRV parameters were normal. This highlights the importance of incorporating non-traditional HRV parameters in CHF patient risk stratification, urging further exploration through comprehensive multicenter studies for long-term prognostic implications.
Nexus Between Political Stability and Economic Growth: An Empirical Study From Nepal
Authors: Dahal Arjun Kumar , Bhattarai Ganesh , Budhathoki Prem Bahadur 
Published: May 2024

Abstract
This study examines the impact of the political stability index, including inflation rate and gross capital formation growth, on Nepal’s economic growth. This study uses secondary data from the World Bank, covering 27 annual data points from 1996 to 2022. Descriptive and exploratory research designs are used. Some statistical and essential econometric tools like graphs, descriptive statistics, correlation analysis, Johnsen co-integration test, vector error correction model, and Wald test are used in the study. The independent and dependent variables exhibit long-term cointegration. The preceding year’s political stability has a favorable influence on current economic expansion. One percent improvement in the previous year’s political stability index led to a 0.1896 percent increase in economic growth. One percent increase in inflation results in a 0.1884 percent decrease in economic growth in Nepal. Similarly, 84.96 percent of the variation in economic growth is influenced by factors such as past economic growth, political stability, inflation, and the expansion rate in gross capital accumulation over an extended period. The short-term economic growth of Nepal is influenced by factors such as the previous year’s economic growth, political stability index, and growth in gross capital formation. Nevertheless, the inflation rate does not statistically explain short-term economic progress. To develop sustainable economic growth in Nepal, it is crucial to undertake critical policy initiatives such as enhancing the political stability index, encouraging capital formation, and efficiently managing inflation.
"Manguni," A Minahasan Cultural Identity: The Application of Practice-Based Research on A Program Music
Authors: Gosal Clifford Israel , Listya Agastya Rama , Komalig Yudi Novrian , Tan Arwin Quiñones 
Published: May 2024

Manguni is a Minahasan term for a carnivorous, nocturnal bird known as an owl. The manguni has the Latin name otus manadensis. Minahasan people believe that the manguni is a bird that brings news from Opo Wailan Wangko or God Almighty. In the modern era, mangunis have become endangered due to hunting and logging of trees that were mangunis' original habitat. The extinction of these birds has impacted the younger generation's understanding of the manguni as the identity of the Minahasan people, as well as the ancestral cultural values found in this bird. This research aims to introduce and preserve the noble values found in manguni to the younger generation through symphonic works that combine Minahasan and Western musical idioms. The use of orchestral instruments in nationalistic works has also been done by Romantic-era composers such as Bedrich Smetana, Antonin Dvorak, Bela Bartok, Zoltan Kodaly, and others. However, Manguni is the first orchestral composition to capture the magical figure of this bird musically. This research applies a qualitative and practice-based approach that positions the researcher as the vital instrument. Several stages of research include conceptualizing the composition, incorporating leitmotifs, adding extramusical ideas, pouring ideas or creations, composing detailed compositions, and evaluating. The research output is a descriptive programmatic musical work that uses manguni as an extramusical idea. Leitmotifs represent the nature and character of the manguni and its meanings to the Minahasan people. The work adopts Minahasan musical idioms, such as the rhythmic patterns of Kabasaran dance and the modes and ornamentation of Maengket singing. The Manguni movement is written in a sonata form consisting of exposition, development, recapitulation, and coda. The techniques used include polytonal, cluster, quartal, artificial harmony, polychord, sequence, augmentation, diminution, and retrograde.
PENGEMBANGAN E-LKPD BERBASIS MIND MAPPING PADA MATERI SIKLUS HIDUP HEWAN KELAS IV SEKOLAH DASAR
Authors: Lani Mei , Fuadiah Nyiayu Fahriza , Lubis Patricia H.M 
Published: May 2024

This research aims to produce a product in the form of mind mapping-based e-LKPD (electronic- Lembar Kerja Peserta Didik) for grade IV elementary school science learning. There were problems found, namely that teachers did not have innovative teaching resources, still used conventional methods, and there were still students who had not reached the KKM scores that had been set by the school. This researcher and development uses the Research and Development method using the ADDIE (Analyze, Design, Development, Implementation, Evaluation) model. The subjects in this research were class IV students at SDN 136 Palembang. Data collection instruments are in the form of questionnaires and documentation. Data analysis in this research is to obtain validity, practicality and effectiveness. This research and development produced an e-LKPD that was valid to use, with a score of 89% in the "Very Valid" category based on the results of one-to-one trials and small groups obtained a score of 89.2% in the "Very Practical" category. As well as the effectiveness value of the learning outcomes, the percentage obtained was 82.75%, so it can be concluded that the e-LKPD developed is valid, practical and effective for use as teaching material in learning.Keywords: e-LKPD, Mind Mapping, ADDIE
PATRIOTISME PEREMPUAN SUNDA PADA TOKOH PARAJI DI PAMENGPEUK, GARUT SELATAN, JAWA BARAT
Authors: Mutiarani Mutiarani , Yoesoef M. , MPSS Pudentia 
Published: May 2024

Penelitian ini bertujuan untuk mendeskripsikan nilai-nilai patriotisme yang direfleksikan pada tokoh Paraji persalinan di Kecamatan Pameungpeuk. Garut Selatan, Jawa Barat. Tradisi perawatan kesehatan ibu dan bayi dengan bantuan paraji telah dilakukan secara turun temurun hingga saat ini di daerah Jawa Barat dan Banten. Paraji merupakan tokoh penting dalam praktik perawatan kesehatan ibu dan bayi secara tradisional bagi masyarakat Sunda.Meskipun kemajuan teknologi medis telah berkembang pesat dan pusat-pusat layanan kesehatan modern terus berkembang di daerah-daerah baik di Jawa Barat maupun Banten, namun keberadaan praktik paraji dalam perawatan kesehatan ibu dan bayi masih bertahan di beberapa daerah di Jawa Barat dan Banten. Metode yang digunakan dalam penelitian ini adalah kualitatif dengan pendekatan deskriptif pada nilai-nilai patriotisme. Data berupa hasil pengamatan, wawancara dan dokumentasi dengan paraji di Pameungpeuk, Garut Selatan, Jawa Barat. Dalam objek yang dikaji, dikumpulkan juga dengan teknik studi Pustaka. Data kemudian diklasifikasikan, diinterpretasi dan dianalisis dengan landasan teoritis yang relevan. Hasil penelitian menunjukkan bahwa tokoh paraji perempuan merepresentasikan 1) nilai patriotism dalam konsep moral humanis yakni memupuk rasa kebersamaan dan keperdulian sosial, 2) nilai patriotisme kultural yakni saling tolong menolong dan religiusitas berbasis nilai-nilai islam dan 3) nilai patriotisme berbasis kepribadian yakni rela berkorban, kesetiaan dan berbudi pekerti. Dengan demikian, diharapkan nilai-nilai yang melekat pada tokoh paraji persalinan dapat menjadi cerminan praktik baik dalam menolong sesama.
INOVASI PEMBELAJARAN BAHASA DAN SASTRA INDONESIA MAHASISWA PRODI PBSI IKTL MELALUI LITERASI BUDAYA
Authors: Wissang Imelda Oliva 
Published: May 2024

Artikel ini mengkaji inovasi pembelajaran bahasa dan sastra Indonesia mahasiswa prodi PBSI IKTL melalui literasi budaya. Adapun permasalahan yang diangkat dalam penelitian, bagaimanakah wujud inovasi literasi budaya dalam pembelajaran bahasa dan sastra Indonesia pada mahasiswa prodi PBSI IKTL (Institut Keguruan dan Teknologi Larantuka). Penelitian bertujuan mendeskripsikan wujud inovasi literasi budaya dalam pembelajaran bahasa dan sastra Indonesia pada mahasiswa prodi PBSI IKTL. Metode penelitian menggunakan metode kualitatif dengan pengumpulan data berupa data verbal, dan nonverbal melalui teknik observasi, catatan langsung, dan dokumentasi. Data dianalisis berdasarkan reduksi data, penyajian data, penarikan kesimpulan, dan verifikasi. Dalam aktivitas literasi budaya sebagai inovasi pembelajaran, secara tidak langsung ditumbuhkembangkan karakter dan nilai-nilai kearifan lokal Lamaholot. Karakter lokal Lamaholot, seperti gemohing (kerja sama), gelekat (saling membantu), gewayan (keikhlasan) yang menjadi landasan aktivitas dan kreativitas mahaiswa prodi PBSI IKTL. Sedangkan nilai kearifan lokal Lamaholot, seperti nilai kedisplinan, nilai kerendahan hati dan kesederhanaan; nilai hormat sesama dan kasih sayang; nilai kejujuran; nilai tanggung jawab; nilai ketakwaan dan toleransi. Nilai-nilai ini menjadi pengikat yang memperkuat komitmen dalam mewujudkan inovasi pembelajaran melalui literasi budaya. Adapun hasil temuan penelitian berkaitan dengan wujud inovasi pembelajaran bahasa dan sastra Indonesia mahasiswa prodi PBSI IKTL melalui literasi budaya, antara lain (1) integrasi pembelajaran melalui penelitian dan pengabdian kepada masyarakat dengan luaran artikel jurnal dan laporan tertulis; (2) forum ilmiah melalui diskusi dan penelusuran jejak budaya, dan (3) kegiatan kreatif melalui aktivitas membaca dan menulis, pengelolaan majalah dinding, buletin prodi, kegiatan perlombaan, pentas seni serta produk berupa hasil karya mahasiswa, dosen serta hasil pendampingan di sekolah-sekolah.