bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of i-STAT Point of Care Implementation in a Pharmacist-Managed Anticoagulation Clinic: A Retrospective Analysis
Authors: Challen Laura Moretti , Nguyen Tuong-Giao , Villalon Aimee 
Published: February 2011

Purpose To evaluate the impact that close monitoring by a clinical pharmacist using the i-STAT point of care (POC) machine had on outcomes of anticoagulation patients. Methods This study was a retrospective chart review of 40 patients with an average age of 58.7 who served as their own historical control. Data collected included international normalized ratio (INR) results, indication for warfarin, adverse drug events, emergency room visits, and hospitalizations both before and after the i-STAT POC implementation (November 2006 to August 2009). Results The proportion of time within therapeutic INR range 2.0 to 3.0 was higher after i-STAT POC implementation compared to before (46.3% and 56.2%; P = .001). When a wider INR range was analyzed (1.8-3.2), the proportion of time within range was 64.6% versus 68.9% ( P = .001). In terms of safety, 27 adverse events were documented before and 22 adverse events were documented after i-STAT implementation. Eighteen hospitalizations were related to bleeding or clotting and were distributed evenly between before and after i-STAT implementation. Percentages of medication nonadherence were 12.5% before and 12.1% after the implementation. Conclusion The results of this study indicate that implementation of the i-STAT POC machine in a pharmacist-managed anticoagulation clinic increased percent of time within therapeutic INR by 9.9%. Patient INR results were better controlled at more stable levels. Furthermore, use of i-STAT POC showed improvement in terms of safety, adherence, and cost. Though the significance of these results requires further study, the promising positive outcomes will certainly encourage implementation of this model on a larger scale.
Case Report: Persistent Elevation in Creatine Phosphokinase Associated with High-Dose Daptomycin Therapy
Authors: Rahbar Aryan , Rabinovich Marina , Abraham Prasad , Holloway Katherine 
Published: February 2011

Objective To report a persistent elevation in creatine phosphokinase (CPK) associated with high-dose daptomycin therapy that did not resolve following discontinuation of daptomycin. Summary A 34-year-old male with HIV/AIDS and stage IV Burkitt lymphoma was admitted for pain management. The patient's initial hospital course was complicated by left brachial deep vein thrombosis (DVT), Clostridium difficile colitis, and pancytopenia. The patient later developed severe sepsis and septic shock secondary to methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecium (VRE), Candida albicans, and Escherichia coli infection. High-dose daptomycin (12 mg/kg) was initiated to treat MRSA and VRE bacteremia. The patient's baseline CPK was 118 U/L, which increased to 327 U/L following 2 days of therapy. The patient's CPK continued to increase to 1648 U/L on day 10 of daptomycin, thereby necessitating a discontinuation of daptomycin and the initiation of linezolid. Six days after discontinuation of therapy, the patient's CPK remained elevated at 1940 U/L. Discussion A Naranjo scale score of 6 was calculated, indicating that daptomycin was the probable cause for the increase in CPK. Although daptomycin is known to cause elevations in CPK, there are limited published data describing this adverse event with high-dose daptomycin therapy. Conclusion High-dose daptomycin is becoming more frequently used in clinical practice, so clinicians should monitor for and report any adverse events associated with this dosing strategy.
Identification of lily pollen 14-3-3 isoforms and their subcellular and time-dependent expression profile
Authors: Pertl Heidi , Rittmann Simon , Schulze Waltraud X. , Obermeyer Gerhard 
Published: February 2011

Abstract
14-3-3 proteins are major regulators in plant development and physiology including primary metabolism and signal transduction pathways, typically via a phosphorylation-dependent interaction with a target protein. Four full-length 14-3-3 isoforms were identified in pollen grains of Lilium longiflorum by screening of a cDNA library and RACE (rapid amplification of cDNA ends)-PCR. Mass spectrometry analysis of partially purified 14-3-3s confirmed the presence of the four isoforms but also indicated the presence of additional, less abundant 14-3-3 isoforms in lily pollen. Separation of partially purified 14-3-3 proteins by two-dimensional gel electrophoresis resulted in nine spots that mainly contained the four major 14-3-3 isoforms. In a first step to examine putative physiological roles of specific 14-3-3 isoforms, their subcellular expression profile during pollen germination and tube growth was monitored using a characterized set of antibodies against 14-3-3 proteins with distinct crossreactivity. The abundance profile of 14-3-3 proteins associated with the cytosol, endomembranes (tonoplast, endoplasmic reticulum, Golgi, mitochondria) and plasma membrane showed high spatial-temporal dynamics. This indicates different targets of 14-3-3 proteins at different organelles and time points during pollen germination and growth.
Coagulation assays based on the Luminescent Oxygen Channeling Immunoassay technology1)
Authors: Kappel Andreas , Stephan Sina , Christ Gerlinde , Haude-Barten Anja , Dahm Madeleine , Schwarz Herbert , Fischer Bodo , Hahn Martin , Althaus Harald , Ehm Matthias , Vitzthum Frank 
Published: February 2011

Abstract

Background: The Luminescent Oxygen Channeling Immunoassay (LOCI®) technology is a well-established homogeneous assay format that allows for fast, accurate, and highly sensitive quantitation of analytes. We set out to develop and prove a novel concept to establish a LOCI format that should principally allow for the determination of the activity of coagulation factors and anticoagulants of clinical relevance.

Methods: The concept is based on the linkage of LOCI nano-beads by a peptide that can be cleaved by a coagulation factor. To prove the principle, we used a peptide that can be cleaved by thrombin.

Results: We were able to show that coagulation activation of plasma or whole blood samples that were combined with the LOCI components degraded the thrombin-sensitive peptide and consequently, led to a reduction of the LOCI signal. Signal reduction was proportional to the amount of active thrombin generated. The research prototype assay allowed for the detection of factor deficiencies in both the extrinsic and intrinsic coagulation pathways, and for the quantification of hirudin, a direct thrombin inhibitor.

Conclusions: Taken together, we conclude that the LOCI technology has the potential for extension to functional blood coagulation assays.
Gas chromatography of indium in macroscopic and carrier-free amounts using quartz and gold as stationary phases
Authors: Serov A. , Eichler R. , Dressler R. , Piguet D. , Türler A. , Vögele A. , Wittwer David , Gäggeler H. W. 
Published: February 2011

AbstractThe chemical investigation of E113 is likely to become soon feasible. The determination of chemical properties of carrier-free amounts of the lighter homologues of element 113, especially indium and thallium, allows designing experimental set-ups and selecting experimental conditions suitable for performing these studies. Here, we present investigations of the interaction of indium species with quartz and gold surfaces. Deposition temperatures as well as enthalpies of adsorption were determined for indiumTdep=739±20 °C (−ΔHads(In)=227±10 kJ mol−1) and for indium hydroxideTdep=250±20 °C (−ΔHads(InOH)= 124±10 kJ mol−1) respectively, on quartz. In case of adsorption of indium on a gold surface only a lower limit of the deposition temperature was establishedTdep>980 °C (−ΔHads(In)≥315±10 kJ mol−1). Investigations of macroscopic amounts of indium in thermosublimation experiments at similar experimental conditions were instrumental to establish a tentative speciation of the observed indium species.
Linear growth and intellectual outcome in children with long-term idiopathic subclinical hypothyroidism
Authors: Cerbone Manuela , Bravaccio Carmela , Capalbo Donatella , Polizzi Miriam , Wasniewska Malgorazata , Cioffi Daniela , Improda Nicola , Valenzise Mariella , Bruzzese Dario , De Luca Filippo , Salerno Mariacarolina 
Published: February 2011

ObjectiveThe treatment of children with subclinical hypothyroidism (SH) is controversial for TSH values between 4.5 and 10 mU/l. The aim of this cross-sectional, controlled study was to evaluate growth and intellectual outcome in children with persistent SH who have never been treated with levothyroxine.Design and methodsClinical and auxological parameters, thyroid function, and intellectual outcome were evaluated in 36 children with persistent SH at the age of 9.7±0.6 (range 4–18.0) years. Children had been followed longitudinally for 3.3±0.3 (range 2.0–9.3) years, from first diagnosis of SH until enrollment in the study. Thirty-six age- and sex-matched children were enrolled in the study as controls.ResultsAt study entry, height (−0.8±0.2 SDS), bone age/chronological age (BA/CA ratio 0.92±0.6), and body mass index (BMI −0.1±0.2 SDS) in SH children were normal. Despite long-term duration of SH, none of these parameters showed a worsening with respect to height (−0.7±0.2 SDS), BA/CA (0.97±0.03), and BMI (−0.1±0.2) at the time of first SH detection. None of the children showed overt signs or symptoms of hypothyroidism during the follow-up.Verbal (99.1±2.2), performance (100.4±1.9), and full-scale (99.7±1.9) intelligence quotient (IQ) scores in SH children were normal and comparable to those of controls. No relationship was detected between IQ scores and the degree or duration of SH.ConclusionsPersistent SH in children is not associated with alterations in growth, bone maturation, BMI, and cognitive function or other complaints that could be ascribed to SH even after several years without therapeutic intervention.
Prevention and Control of Phosphate Retention/Hyperphosphatemia in CKD-MBD
Authors: Martin Kevin J. , González Esther A. 
Published: February 2011

Summary
Phosphate retention and, later, hyperphosphatemia are key contributors to chronic kidney disease (CKD)–mineral and bone disorder (MBD). Phosphate homeostatic mechanisms maintain normal phosphorus levels until late-stage CKD, because of early increases in parathyroid hormone (PTH) and fibroblast growth factor-23 (FGF-23). Increased serum phosphorus, and these other mineral abnormalities, individually and collectively contribute to bone disease, vascular calcification, and cardiovascular disease. Earlier phosphate control may, therefore, help reduce the early clinical consequences of CKD-MBD, and help control hyperphosphatemia and secondary hyperparathyroidism in late-stage CKD. Indeed, it is now widely accepted that achieving normal phosphorus levels is associated with distinct clinical benefits. This therapeutic goal is achievable in CKD stages 3 to 5 but more difficult in dialysis patients. Currently, phosphate control is only initiated when hyperphosphatemia occurs, but a potentially beneficial and simple approach may be to intervene earlier, for example, when tubular phosphate reabsorption is substantially diminished. Early CKD-MBD management includes dietary phosphate restriction, phosphate binder therapy, and vitamin D supplementation. Directly treating phosphorus may be the most beneficial approach because this can reduce serum phosphorus, PTH, and FGF-23. This involves dietary measures, but these are not always sufficient, and it can be more effective to also consider phosphate binder use. Vitamin D sterols can improve vitamin D deficiency and PTH levels but may worsen phosphate retention and increase FGF-23 levels, and thus, may also require concomitant phosphate binder therapy. This article discusses when and how to optimize phosphate control to provide the best clinical outcomes in CKD-MBD patients.
Methodology of splicing large air filling factor suspended core photonic crystal fibres
Authors: Jaroszewicz L. , Murawski M. , Nasilowski T. , Stasiewicz K. , Marć P. , Szymański M. , Mergo P. 
Published: February 2011

AbstractWe report the methodology of effective low-loss fusion splicing a photonic crystal fibre (PCF) to itself as well as to a standard single mode fibre (SMF). Distinctly from other papers in this area, we report on the results for splicing suspended core (SC) PCF having tiny core and non-Gaussian shape of guided beam. We show that studied splices exhibit transmission losses strongly dispersive and non-reciprocal in view of light propagation direction. Achieved splicing losses, defined as larger decrease in transmitted optical power comparing both propagation directions, are equal to 2.71 ±0.25 dB, 1.55 ±0.25 dB at 1550 nm for fibre SC PCF spliced to itself and to SMF, respectively.
A survey of galliform monitoring programs and methods in the United States and Canada
Authors: Sands Joseph P. , Pope Michael D. 
Published: February 2011

AbstractWe mailed survey questionnaires to 62 upland game bird managers in the United States and Canada in 2004. We received questionnaires from 47 of the 62 (76%) upland game bird managers that were contacted and 43 (91%) respondents provided information on how monitoring data were used. Responses indicated monitoring programs (population trends and/or harvest monitoring) for 23 species of Galliformes, with 145 ± 208 personnel days/year devoted to monitoring. Estimating general population trends (e.g. up or down) was the most frequent objective (N = 41; 95%) of survey data. Other applications of data included assessments of hunting activity, evaluations of regional programs and reviews of conservation status related to Endangered Species Act petitions. The majority of respondents (i.e. 63%) with monitoring programs considered the programs within their states to be effective with respect to their objectives. Many states rely upon hunter surveys, harvest data or road counts to access demographic and population data to address major conservation and management issues. The relevance of these issues is growing and agencies must respond with management recommendations, but often must do so with limited data on the status of their populations. Comprehensive monitoring should be a major component of conservation and management planning for upland gamebird populations particularly as a tool to track and evaluate the effectiveness of management actions and inform management options.
Interactions between Pain and the Motor Cortex: Insights from Research on Phantom Limb Pain and Complex Regional Pain Syndrome
Authors: Mercier Catherine , Léonard Guillaume 
Published: February 2011

Purpose: Pain is a significantly disabling problem that often interacts with other deficits during the rehabilitation process. The aim of this paper is to review evidence of interactions between pain and the motor cortex in order to attempt to answer the following questions: (1) Does acute pain interfere with motor-cortex activity? (2) Does chronic pain interfere with motor-cortex activity, and, conversely, does motor-cortex plasticity contribute to chronic pain? (3) Can the induction of motor plasticity by means of motor-cortex stimulation decrease pain? (4) Can motor training result in both motor-cortex reorganization and pain relief? Summary of Key Points: Acute experimental pain has been clearly shown to exert an inhibitory influence over the motor cortex, which can interfere with motor learning capacities. Current evidence also suggests a relationship between chronic pain and motor-cortex reorganization, but it is still unclear whether one causes the other. However, there is growing evidence that interventions aimed at normalizing motor-cortex organization can lead to pain relief. Conclusions: Interactions between pain and the motor cortex are complex, and more studies are needed to understand these interactions in our patients, as well as to develop optimal rehabilitative strategies.
Ankylosing spondylitis of the craniovertebral junction: a single surgeon's experience
Authors: Albert Gregory W. , Menezes Arnold H. 
Published: February 2011

Object
The objective of this study was to describe a single surgeon's experience managing craniovertebral junction (CVJ) disease due to ankylosing spondylitis.

Methods
The authors undertook a retrospective review of the records of patients with CVJ disease due to ankylosing spondylitis who were evaluated and treated by the senior author. Charts were reviewed for symptoms and signs at presentation, radiography results, treatment, and outcome. In addition, some of the patients had pathology reports available for review.

Results
Eight patients with CVJ disease due to ankylosing spondylitis were identified who were evaluated by the senior author in the years 1990–2008. The most common presenting symptoms were neck pain (37.5%), cranial neuropathy (37.5%), and sensory disturbance (62.5%). On examination, the most common findings were limited cervical range of motion (37.5%), weakness (50%), and myelopathy (75%). Radiographic evaluation revealed atlantoaxial subluxation, retroodontoid pannus formation, basilar invagination, and bone erosion. Surgery was offered to all of the patients, 7 of whom underwent operations. In most cases, the treatment was transoral–transpalatopharyngeal decompression followed by occipitocervical fusion. One patient with a reducible lesion underwent dorsal fusion alone. Neurological outcomes were favorable overall.

Conclusions
The incidence of CVJ disease in patients with ankylosing spondylitis varies among reports. These cases are rare in most neurosurgery clinics. It is important to recognize that patients with ankylosing spondylitis are at risk for CVJ disease, similar to patients with rheumatoid arthritis. Principles common to the management of other CVJ pathologies apply to these patients as well.
Heterotopic ossification after cervical total disc replacement: determination by CT and effects on clinical outcomes
Authors: Tu Tsung-Hsi , Wu Jau-Ching , Huang Wen-Cheng , Guo Wan-Yuo , Wu Ching-Lan , Shih Yang-Hsin , Cheng Henrich 
Published: February 2011

Object
Heterotopic ossification (HO) after cervical total disc replacement (TDR) has been reported to impede artificial disc motion. In all previously reported cases of HO, assessment was based on plain radiographs. The authors hypothesized that CT scan is a more sensitive and accurate detector. The aims of this study were to assess the actual incidence of HO and its effect on outcome in a cohort of patients undergoing cervical TDR with the Bryan disc and to compare HO detection by means of plain radiographs and CT.

Methods
The authors retrospectively assessed data from medical records, radiological studies, and clinical evaluations of patients who underwent 1- or 2-level cervical TDR with the Bryan disc and were followed up for more than 12 months. The presence and grading of HO according to the McAfee classification were assessed by CT scan, and these findings were compared with findings on plain radiographs. Thirty-six patients (mean age 46.61 ± 7.24 years; range 29–60 years; 21 men and 15 women) who underwent Bryan TDR at 52 levels were included in the study. The mean duration of CT follow-up was 19.03 ± 4.64 months; the mean duration of clinical follow-up was 26.78 ± 7.20 months.

Results
On the basis of CT, HO was identified in 18 (50%) of 36 patients and 25 (48.1%) of 52 levels treated. Grade 1 HO was present in 9 of the levels treated (17.3%), Grade 2 in 13 levels (25.0%), Grade 3 in 2 levels (3.8%), and Grade 4 in 1 level (1.9%). Nineteen (76%) of the 25 affected levels were in patients who had undergone 2-level TDR. There was no significant association with patient sex or disc pathology. There was a tendency for HO development among older patients, but this finding was not statistically significant (mean age 48.8 ± 6.8 in patients with HO vs 44.4 ± 7.2 in those without HO, p = 0.065). Although HO was found in 25 levels, 96.2% of the treated levels (50 of 52) had segmental range of motion on dynamic (flexion and extension) radiographs. The concordance between HO grading by CT and radiography was high, with an intraclass correlation coefficient of 0.822 (lower limit of 95% CI: 0.710, p < 0.001). Patients who had HO had the same clinical success rate as those who did not (94.4% vs 94.4%, p = 1.00). The visual analog scale scores for neck and arm pain were significantly improved in both the HO and the non-HO group.

Conclusions
The rate of HO detected by CT scan in this cohort of patients undergoing cervical TDR with a Bryan disc was 48.1% per level treated and 50% per patient with minimal limitation of segmental motion (96.2% of levels remained mobile), but plain radiograph is an acceptable detection tool. Two-level surgery has a higher risk of HO, although development of HO does not affect clinical outcome.
Les comportements de travail et de loisir : facteurs de mobilité des populations tsiganes
Authors: Humeau Jean-Baptiste 
Published: February 2011

L'analyse des composantes géographiques nées des comportements de loisir doit-elle se limiter à la connaissance des phénomènes dérivés de la fréquentation des équipements de loisirs ?
L'auteur propose une observation de la mobilité géographique de quelques familles tsiganes dans le Val de Loire. Il s'Interroge sur les facteurs de cette mobilité, montrant qu'à travers le choix des lieux de stationnement il y a combinaison des notions de travail et de loisir. Certes, ces concepts sont éloignés de ceux élaborés par la société sédentaire d'un pays industrialisé, cependant ils attestent que le nomadisme des Tsiganes n'est pas seulement une errance, mais la résultante d'un mode de vie fondé sur une utilisation tout à fait spécifique de l'espace.
La série du chêne pubescent dans le Haut-Poitou oriental
Authors: Gesan Marcel 
Published: February 2011

The region around Sillars and Lussac Les Châteaux (Haut Poitou) offers a subsoil which consists of marine limestone deposits dating from the secondary era (Mesozoic era). The many dry valleys, the resurgent springs, the caves give evidence of the erosion following their emergence from the sea. Plants which particularly flourish in warm, sunny conditions and in a limestone-type soil have developed in the carbonated soil which resulted from the weathering of the underlying rock.
A typical example of the xerophilous species of tree is the durma (st) oak which grows here alongside shrubs of which the most common are box and juniper. However the widespread growth of oak-trees is prevented by sheep grazing. On the sunny hillsides, one can see several species of vegetation which are normally found in the mediterranean area.
Theodore, archetype of the warrior saint
Authors: Walter Christopher 
Published: February 2011

REB 57 1999 France p. 163
Christopher Walter, Theodore, Archetype of the Warrior Saint. — Les origines du culte de saint Théodore sont étudiées en vue d'élaborer une approche méthodologique qui vaudrait pour les autres saints. Sont examinés un à un les plus anciens textes concernant Théodore, l'établissement de son sanctuaire à Euchaïtes, l'expansion de son culte, la nature de ses interventions comme saint militaire dans la vie terrestre des hommes, l'émergence de son «jumeau» Théodore Stratèlatès qui disposait de son propre sanctuaire à Euchaneia et, enfin, la place de l'iconographie des deux Théodore dans l'esthétique byzantine.
À propos de la promotion patriarcale d'Athanase de Constantinople
Authors: Failler Albert 
Published: February 2011

REB 57 1999 France p. 237
Albert Failler, À propos de la promotion patriarcale d'Athanase de Constantinople. — In writing that Athanasius «reached St Sophia by foot on the 14th October» (1289), George Pachymeres thereby dates the solemn transfer of the patriarch from the Palace to the Patriarchate following immediately upon his promotion by the emperor in the Palace. This date, then, is to be given to Athanasius' promotion as patriarch, not to his episcopal ordination.