bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Perspective on Coronary Bifurcation Intervention: Statement of the “Bifurcation Club in KOKURA”
Authors: MURASATO YOSHINOBU , HIKICHI YUTAKA , NAKAMURA SUNAO , KAJIYA FUMIHIKO , IWASAKI KIYOTAKA , KINOSHITA YOSHIHISA , YAMAWAKI MASAHIRO , SHINKE TOSHIRO , YAMADA SHNICHIRO , YAMASHITA TAKEHIRO , CHOO GIM‐HOOI , NAM CHANG‐WOOK , KIM YOUNG‐HAK , JEPSON NIGEL , FERENC MIROSLAW 
Published: August 2010

The treatment of coronary bifurcation lesion remains a challenging issue even in the drug‐eluting stent era. Frequent restenosis and stent thrombosis have been recently shown to be related not only to geometrical gap or stent structural deformation but also to rheological disturbance. Low wall shear stress at the lateral side of the bifurcation is likely to cause atherosclerotic changes due to easy access of the macrophages that induce chemical mediators. The turbulent flow over stent metal may facilitate accumulation of platelets, which results in thrombosis. The jailed strut and excess metal overlap may increase these risks. Since dramatic changes of the coronary flow pattern at the bifurcation are closely related to the genesis of atherosclerosis, future bifurcation intervention technique should be considered to restore the original physiological state as well as the anatomical structure. This article summarizes the global consensus of the members of the Asian Bifurcation Club and European Bifurcation Club at the KOKURA meeting. It also provides a perspective of basic sciences relating to bifurcation anatomy, physiology, and pathology, in the search for a best strategy for bifurcation intervention. (J Interven Cardiol 2010;23:295–304)
Incomplete Aneurysm Coverage after Patent Foramen Ovale Closure in Patients with Huge Atrial Septal Aneurysm: Effects on Left Atrial Functional Remodeling
Authors: RIGATELLI GIANLUCA , RONCO FEDERICO , CARDAIOLI PAOLO , DELL’AVVOCATA FABIO , BRAGGION GABRIELE , GIORDAN MASSIMO , AGGIO SILVIO 
Published: August 2010

Background: Large devices are often implanted to treat patent foramen ovale (PFO) and atrial septal aneurysm (ASA) with increase risk of erosion and thrombosis. Our study is aimed to assess the impact on left atrium functional remodeling and clinical outcomes of partial coverage of the approach using moderately small Amplatzer ASD Cribriform Occluder in patients with large PFO and ASA.
Methods: We prospectively enrolled 30 consecutive patients with previous stroke (mean age 36 ± 9.5 years, 19 females), significant PFO, and large ASA referred to our center for catheter‐based PFO closure. Left atrium (LA) passive and active emptying, LA conduit function, and LA ejection fraction were computed before and after 6 months from the procedure by echocardiography. The preclosure values were compared to values of a normal healthy population of sex and heart rate matched 30 patients.
Results: Preclosure values demonstrated significantly greater reservoir function as well as passive and active emptying, with significantly reduced conduit function and LA ejection fraction, when compared normal healthy subjects. All patients underwent successful transcatheter closure (25 mm device in 15 patients, 30 mm device in 6 patients, mean ratio device/diameter of the interatrial septum = 0.74). Incomplete ASA coverage in both orthogonal views was observed in 21 patients. Compared to patients with complete coverage, there were no differences in LA functional parameters and occlusion rates.
Conclusions: This study confirmed that large ASAs are associated with LA dysfunction. The use of relatively small Amplatzer ASD Cribriform Occluder devices is probably effective enough to promote functional remodeling of the left atrium. (J Interven Cardiol 2010;23:362–367)
Impact of Childhood Cancer on Parents’ Relationships: An Integrative Review
Authors: Da Silva Fernanda Machado , Jacob Eufemia , Nascimento Lucila Castanheira 
Published: August 2010

Abstract Purpose: The diagnosis of cancer and the treatment decisions associated with it may cause uncertainty, stress, and anxiety among parents. Emotional tensions can affect parents’ relationships during the trajectory of the child's cancer illness. We conducted an integrative review to examine the evidence related to the effects of childhood cancer on parents’ relationships. Methods: An integrative literature search of studies published between 1997 and 2009 was conducted in the Cumulative Index to Nursing and Allied Health Literature (CINAHL), Psychology Information (PsycINFO), PubMed, Scopus, CUIDEN, and Latin American and Caribbean Health Science Literature (LILACS). The key words used were neoplasms, child, marriage, spouses, family relations, and nursing. Articles were reviewed if the (a) topic addressed parents’ relationships during childhood cancer; (b) participants were mothers, fathers, or both; (c) design was either qualitative or quantitative; (d) language was English, Portuguese, or Spanish; (e) date of publication was between January 1997 and October 2009; and (f) abstract was available. Results: Fourteen articles met the search criteria and were reviewed using Cooper's framework for integrative reviews. Four themes emerged: (a) changes in the parents’ relationship during the trajectory of the child's illness; (b) difficulty in communication between couples; (c) gender differences in parental stress and coping; and (d) role changes. Conclusions and Implications: Findings revealed positive and negative changes in parents’ relationships, communication, stress, and roles. Nurses need to assess the impact of cancer diagnosis and treatments on parent relationships, offer support and encouragement, and allow expression of feelings. Future research is needed to develop and test interventions that increase parents’ potentials and strengthen relationships during the challenging trajectory of their children's cancer and treatment. Clinical Relevance: The multiple sources of stress and uncertainty associated with a child's cancer diagnosis and treatment affect parents’ relationships. Difficulties in communication appear frequently in parents’ relationship. Our findings may guide healthcare professionals in identifying parents at risk for developing conflicts, communication problems, and lack of alignment between parents that could interfere with providing optimal care for their child with cancer. Healthcare professionals may promote dialogue and encourage parents to express their feelings, seek mutual support, and establish a partnership in dealing with the child's illness.
Reduction of reperfusion‐induced ventricular fibrillation and infarct size via heme oxygenase‐1 overexpression in isolated mouse hearts
Authors: Bak Istvan , Czompa Attila , Juhasz Bela , Lekli Istvan , Tosaki Arpad 
Published: August 2010

AbstractHeme oxygenase‐1 (HO‐1), also known as heat shock protein 32 (hsp‐32) is a stress‐induced cytoprotective protein. The present investigation evaluated the capacity of HO‐1 to reduce the incidence of reperfusion‐induced ventricular fibrillation (VF) and infarct size. HO‐1 transgenic (Tg) mice were generated using a rat HO‐1 genomic transgene. Isolated mouse hearts obtained from Tg and non‐transgenic (NTg) groups were exposed to 20 min. of global ischemia and 120 min. of reperfusion. Epicardial electrocardiogram was recorded to monitor the incidence of reperfusion‐induced VF and at the end of the reperfusion period, detection of HO‐1 by immunohistochemistry and measurement of infarct size using the tetrazolium chloride method were carried out. Results shown here provide additional support for cardioprotective effects of HO‐1 as demonstrated by the reduced infarct size. Moreover, overexpression of the HO‐1 efficiently reduced the incidence of ischemia/reperfusion induced VF in HO‐1 Tg mice.
The roles of p27Kip1 and DNA damage signalling in the chemotherapy‐induced delayed cell cycle checkpoint
Authors: Liontos Michalis , Velimezi Georgia , Pateras Ioannis S. , Angelopoulou Roxani , Papavassiliou Athanasios G. , Bartek Jiri , Gorgoulis Vassilis G. 
Published: August 2010

AbstractDNA lesions trigger the DNA damage response (DDR) machinery, which protects genomic integrity and sustains cellular survival. Increasing data underline the significance of the integrity of the DDR pathway in chemotherapy response. According to a recent work, persistent exposure of A549 lung carcinoma cells to doxorubicin induces an initial DDR‐dependent checkpoint response, followed by a later DDR‐independent, but p27Kip1‐dependent one. Prompted by the above report and to better understand the involvement of the DDR signaling after chemotherapeutic stress, we examined the potential role of the canonical DDR pathway in A549 cells treated with doxorubicin. Exposure of A549 cells, prior to doxorubicin treatment, to ATM, ATR and DNA‐PKcs inhibitors either alone or in various combinations, revealed that the earlier documented two‐step response was DDR‐dependent in both steps. Notably, inhibition of both ATM and ATR or selective inhibition of ATM or DNA‐PKcs resulted in cell‐cycle re‐entry despite the increased levels of p27Kip1 at all time points analyzed. We further investigated the regulation of p27Kip1 protein levels in the particular setting. Our results showed that the protein status of p27Kip1 is mainly determined by p38‐MAPK, whereas the role of SKP2 is less significant in the doxoroubicin‐treated A549 cells. Cumulatively, we provide evidence that the DNA damage signaling is responsible for the prolonged cell cycle arrest observed after persistent chemotherapy‐induced genotoxic stress. In conclusion, precise identification of the molecular mechanisms that are activated during the chemotherapeutic cycles could potentially increase the sensitization to the therapy applied.
Dopamine release in ventral striatum of pathological gamblers losing money
Authors: Linnet J. , Peterson E. , Doudet D. J. , Gjedde A. , Møller A. 
Published: August 2010

Linnet J, Peterson E, Doudet DJ, Gjedde A, Møller A. Dopamine release in ventral striatum of pathological gamblers losing money.Objective:  To investigate dopaminergic neurotransmission in relation to monetary reward and punishment in pathological gambling. Pathological gamblers (PG) often continue gambling despite losses, known as ‘chasing one’s losses’. We therefore hypothesized that losing money would be associated with increased dopamine release in the ventral striatum of PG compared with healthy controls (HC).Method:  We used Positron Emission Tomography (PET) with [11C]raclopride to measure dopamine release in the ventral striatum of 16 PG and 15 HC playing the Iowa Gambling Task (IGT).Results:  PG who lost money had significantly increased dopamine release in the left ventral striatum compared with HC. PG and HC who won money did not differ in dopamine release.Conclusion:  Our findings suggest a dopaminergic basis of monetary losses in pathological gambling, which might explain loss‐chasing behavior. The findings may have implications for the understanding of dopamine dysfunctions and impaired decision‐making in pathological gambling and substance‐related addictions.
The socket‐shield technique: a proof‐of‐principle report
Authors: Hürzeler Markus B. , Zuhr Otto , Schupbach Peter , Rebele Stephan F. , Emmanouilidis Notis , Fickl Stefan 
Published: August 2010

Hürzeler MB, Zuhr O, Schupbach P, Rebele SF, Emmanouilidis N, Fickl S. The socket‐shield technique: a proof‐of‐principle report. J Clin Periodontol 2010; 37: 855–862. doi: 10.1111/j.1600‐051X.2010.01595.x. AbstractAim: Clinical studies have suggested that retaining roots of hopeless teeth may avoid tissue alterations after tooth extraction. Therefore, the objective of this proof‐of‐principle experiment was to histologically assess a partial root retention (socket‐shield technique) in combination with immediate implant placement.Material and Methods: In one beagle dog, the third and fourth mandibular pre‐molar were hemisected and the buccal fragment of the distal root was retained approximately 1 mm coronal to the buccal bone plate. Following application of enamel matrix derivate, a titanium implant was placed lingual to that tooth fragment either with or without contact to the buccal tooth fragment and a healing abutment was connected. Four months after implant placement, histological evaluation, and backscatter scanning electron microscopy were performed.Results: All four implants were osseointegrated without any histologic inflammatory reaction and the tooth fragment was devoid of any resorptional processes. On the buccal side, the tooth fragment was attached to the buccal bone plate by a physiologic periodontal ligament. On the lingual side of the fragment, newly formed cementum could be detected. In the areas where the implant was placed into the fragment, newly formed cementum was demonstrated directly on the implant surface.Conclusions: Retaining the buccal aspect of the root during implant placement does not appear to interfere with osseointegration and may be beneficial in preserving the buccal bone plate.
Prevalence of dental erosion in children: a national survey
Authors: Arnadottir Inga B. , Holbrook W. Peter , Eggertsson Hafsteinn , Gudmundsdottir Holmfridur , Jonsson Stefan Hrafn , Gudlaugsson Jon Oskar , Saemundsson Sigurdur Runar , Eliasson Sigfus T. , Agustsdottir Helga 
Published: August 2010

Arnadottir IB, Holbrook WP, Eggertsson H, Gudmundsdottir H, Jonsson SH, Gudlaugsson JO, Saemundsson SR, Eliasson ST, Agustsdottir H. Prevalence of dental erosion in children: a national survey. Community Dent Oral Epidemiol 2010; 38: 521–526. © 2010 John Wiley & Sons A/SAbstract – Objectives: To measure the prevalence of dental erosion in permanent teeth in Iceland as part of the National Oral Health Survey.Methods: A representative, nationwide sample of 2251 Icelandic children, 20% of those aged 6, 12 and 15 year, was examined. Dental erosion was recorded for all erupted permanent teeth and graded using the modified scale of Lussi.Results: Erosion was not seen in the permanent teeth of six‐year‐olds, but was present in 15.7% of 12‐year‐olds, more frequently in boys than girls (19.9% boys, 11.0% girls; P < 0.001). Among 15‐year‐olds, dental erosion was seen among 30.7% of subjects (38.3% boys, 22.7% girls; P < 0.001). Severity of erosion was mostly scored as grade I, with only 5.5% of 15‐year‐olds scored as grade II, mostly on tooth 46 (4.3%) and 36 (4.2%). For 12‐year‐olds, 0.9% had erosion scores of grade II mostly on tooth 46 (0.8%) and 36 (0.7%). No subjects had erosion of grade III. The most common clinical manifestation of erosion was the appearance of cup‐like lesions on the cusps of lower first molars.Conclusions:  Dental erosion was frequently present by the age of 12; the prevalence doubled by age 15 and was seen almost twice as often among boys than girls. Teeth most frequently showing signs of erosion were the lower first molars. The rapidly growing prevalence of erosion demonstrated by this nationwide survey emphasizes the need for further research into the aetiology of erosion and possible methods of preventing and treating this emerging dental problem.
A possible case of hantavirus infection in a Borneo orangutan and its conservation implication
Authors: Chen C.‐C. , Pei K.J.‐C. , Yang C.‐M. , Kuo M.‐D. , Wong S.‐T. , Kuo S.‐C. , Lin F.‐G. 
Published: August 2010

AbstractBackground  Natural infection of hantavirus in orangutans has never been reported.Methods  Enzyme‐linked immunosorbent assays (ELISA), Indirect immunofluorescence assay (IFA), and RT‐PCR were used to diagnosis a suspected case in a pet orangutan in southern Taiwan.Results  Although the RT‐PCR result was negative, the high IgG titer in the beginning and its dramatic drop after treatments suggested a recent Seoul‐type hantavirus infection.Conclusions  Hantavirus transmission and its potential damage to wild orangutans should not be overlooked.
Dentin surface treatment using a non‐thermal argon plasma brush for interfacial bonding improvement in composite restoration
Authors: Ritts Andy C. , Li Hao , Yu Qingsong , Xu Changqi , Yao Xiaomei , Hong Liang , Wang Yong 
Published: August 2010

Ritts AC, Li H, Yu Q, Xu C, Yao X, Hong L, Wang Y. Dentin surface treatment using a non‐thermal argon plasma brush for interfacial bonding improvement in composite restoration. Eur J Oral Sci 2010; 118: 510–516. © 2010 Eur J Oral Sci The objective of this study was to investigate the treatment effects of non‐thermal atmospheric gas plasmas on dentin surfaces used for composite restoration. Extracted unerupted human third molars were prepared by removing the crowns and etching the exposed dentin surfaces with 35% phosphoric acid gel. The dentin surfaces were treated using a non‐thermal atmospheric argon plasma brush for various periods of time. The molecular changes of the dentin surfaces were analyzed using Fourier transform infrared spectrophotometry/attenuated total reflectance (FTIR/ATR), and an increase in the amount of carbonyl groups was detected on plasma‐treated dentin surfaces. Adper Single Bond Plus adhesive and Filtek Z250 dental composite were applied as directed. To evaluate the dentin/composite interfacial bonding, the teeth thus prepared were sectioned into micro‐bars and analyzed using tensile testing. Student–Newman–Keuls tests showed that the bonding strength of the composite restoration to peripheral dentin was significantly increased (by 64%) after 30 s of plasma treatment. However, the bonding strength to plasma‐treated inner dentin did not show any improvement. It was found that plasma treatment of the peripheral dentin surface for up to 100 s resulted in an increase in the interfacial bonding strength, while prolonged plasma treatment of dentin surfaces (e.g. 5 min) resulted in a decrease in the interfacial bonding strength.
Applicability of an exaggerated forearm wash test for efficacy testing of two corticosteroids, tacrolimus and glycerol, in topical formulations against skin irritation induced by two different irritants
Authors: Clemmensen A. , Andersen F. , Petersen T. K. , Hagberg O. , Andersen K. E. 
Published: August 2010

Background/Purpose: Alternatives to corticosteroids in the treatment of irritant contact dermatitis (ICD) are needed and may include glycerol and topical immunomodulators like tacrolimus. Because the efficacy of different treatments in experimentally induced ICD may vary depending on the irritant applied, we tested the efficacy of four anti‐irritant compounds using the two different irritants sodium lauryl sulfate (SLS) and nonanoic acid (NON).Methods: In a randomized, double‐blind, controlled trial, healthy volunteers were exposed to 5% SLS and 50% NON (the right and the left forearm, respectively) in a cumulative wash test. Induction of ICD was obtained by three daily washings for 7 days, followed by a maintenance phase with two daily washings for 12 days. Treatment (triamcinolone acetonide, clobetasol propionate, tacrolimus and glycerol ointment) was started at day 7 and applied immediately after washing. Vehicle and no treatment served as the control. Reactions were evaluated clinically and instrumentally.Results: No treatments were significantly better than the other treatments and controls. There was a tendency toward a dose‐dependent response to corticoid treatment, and a trend toward worsened irritancy by tacrolimus on SLS‐irritated skin. Explained variance in the experiment by anova revealed a very small effect of treatments compared with an immense and significant subject effect.Conclusion: No claims of effective anti‐irritant properties for any of the ointments can be maintained. Application of the present wash test as a tool for anti‐irritant efficacy testing may be complicated by the small observed variance explained by treatment.
Peripheral Blood Cytokine Profiling During Pregnancy and Post‐partum Periods
Authors: Kraus Thomas A. , Sperling Rhoda S. , Engel Stephanie M. , Lo Yungtai , Kellerman Lisa , Singh Tricia , Loubeau Martine , Ge Yongchao , Garrido Jose L. , Rodríguez‐García Marta , Moran Thomas M. 
Published: August 2010

Citation Kraus TA, Sperling RS, Engel SM, Lo Y, Kellerman L, Singh T, Loubeau M, Ge Y, Garrido JL, Rodríguez‐García M, Moran TM. Peripheral blood cytokine profiling during pregnancy and post‐partum periods. Am J Reprod Immunol 2010; 64: 411–426Problem  Pregnancy requires that the maternal immune system adapt to prevent rejection of the fetal semi‐allograft. This immunologic adaptation may contribute to pregnancy‐related alterations in disease susceptibility and severity of infections from viral pathogens such as influenza virus.Method of Study  As part of a larger study investigating the maternal systemic immune response during pregnancy, peripheral blood was collected three times during pregnancy and twice post‐partum to measure serum levels of 23 cytokines, chemokines, and growth factors. This longitudinal study design allowed each woman’s post‐partum blood draw to serve as her own comparison, thus controlling for interpersonal variability in expression levels.Results  When compared to the post‐partum samples, significant pregnancy‐related changes in IFNγ, TNFα, VEGF, GCSF, Eotaxin, and MCP‐1 expression were observed. These changes have significant immunologic effects in vivo and in culture.Conclusion  Pregnancy‐associated changes to steady state serum cytokines may have important immunologic consequence.
Presumed and definite bacteremia in extremely low gestational age newborns
Authors: Patel Sonal , Dammann Olaf , Martin Camilia R , Allred Elizabeth N , Leviton Alan ,   for the ELGAN Study Investigators
Published: August 2010

AbstractAim:  To explore risk patterns for presumed and definite, early and late neonatal bacteremia.Methods:  We studied 1106 extremely low gestational age newborns who survived until postnatal day 28. We defined early definite bacteremia as a positive bacterial culture in the first week and definite late bacteremia as a positive bacterial culture in week 2, 3 or 4. Bacteremia was presumed if antibiotics were given for more than 72 h despite negative blood cultures.Results:  Risk patterns did not differ much for presumed and definite bacteremia in the first postnatal month. While maternal and pregnancy characteristics were associated with early bacteremia, neonatal comorbidities, especially NEC, were the main antecedents/correlates of late bacteremia. All four categories of bacteremia were associated with younger gestational age and lower birth weight. Infants with presumed and definite bacteremia had similar distributions of days of ventilation and oxygenation.Conclusion:  Definite and presumed late bacteremias have rather similar risk patterns, while those of early and late bacteremia differ appreciably.