bluuebunny/crossref_metadata_2025_split huggingface dataset:
A frequency‐domain‐based master stability function for synchronization in nonlinear periodic oscillators
Authors: Righero Marco , Corinto Fernando , Biey Mario 
Published: October 2011

SUMMARYAn efficient methodology to study conditions for stable in‐phase synchronization in networks of periodic identical nonlinear oscillators is proposed. The problem of investigating synchronization properties on periodic trajectories is reduced to an eigenvalue problem by means of the joint application of master stability function and harmonic balance techniques. The proposed method permits to exploit the periodicity of trajectories, reducing computational time with respect to traditional time‐domain approaches (which were designed to deal with generic attractors) and good accuracy. In addition, such method can easily deal with networks of nonlinear periodic oscillators described by differential‐algebraic equations, and then both static and dynamic coupling could be studied. Copyright © 2011 John Wiley & Sons, Ltd.
Barrier effect of flame retardant systems in poly(methyl methacrylate): Study of the efficiency of the surface treatment by octylsilane of silica nanoparticles in combination with phosphorous fire retardant additives
Authors: Quach Yen , Cinausero Nicolas , Sonnier Rodolphe , Longuet Claire , Lopez‐Cuesta Jose‐Marie 
Published: October 2011

SUMMARYIn this work, flame retardant systems comprising ammonium polyphosphate (AP423) and hydrophilic (A200) or hydrophobic (R805) nanometric silica were incorporated into PMMA. The following techniques were performed to detail the fire behaviour of the composites: mass loss cone calorimetry, pyrolysis‐combustion flow calorimetry, pyrolysis‐gas chromatography–mass spectrometry, thermogravimetric analysis, X‐ray diffraction analysis, Fourier transform infrared spectroscopy and microscopic observations. The best fire behaviour was obtained with the surface‐treated silica in the presence of AP423. The formation of a new crystalline phase from the interactions between AP423 and R805 silica and a strong barrier effect due to a layered residue were the main modes of action of this system. Moreover, we have shown that the difference between the AP423 + R805 and AP423 + A200 systems was due to poor dispersion of the silica into the PMMA matrix in the latter formulation. Copyright © 2011 John Wiley & Sons, Ltd.
A review of in‐vivo optical properties of human tissues and its impact on PDT
Authors: Sandell Julia L. , Zhu Timothy C. 
Published: October 2011

AbstractA thorough understanding of optical properties of biological tissues is critical to effective treatment planning for therapies such as photodynamic therapy (PDT). In the last two decades, new technologies, such as broadband diffuse spectroscopy, have been developed to obtain in vivo data in humans that was not possible before. We found that the in vivo optical properties generally vary in the ranges μa = 0.03–1.6 cm–1 and μs′ = 1.2–40 cm–1, although the actual range is tissue‐type dependent. We have also examined the overall trend of the absorption spectra (for μa and μs′) as a function of wavelength within a 95% confidence interval for various tissues in vivo. The impact of optical properties on light fluence rate is also discussed for various light application geometries including superficial, interstitial, and within a cavity. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A Facile Synthesis and Structural Verification of Etorphine and Dihydroetorphine from Codeine
Authors: Huang Xin‐Ren , Srimurugan Sankareswaran , Lee Gene‐Hsiang , Chen Chinpiao 
Published: October 2011

AbstractIn this study, an improved process for the synthesis of etorphine and dihydroetorphine from codeine with an overall yield of 2.7% and 1.5% respectively is described. The structure of 19‐propylthevinol 7 was verfied by X‐ray structure analysis. This result is promising for synthesizing various morphine‐based drugs.
Synthesis and Characterization of the First Doubly‐bridged N,N‐dimethylthiocarbamoyl Metal Complex: Crystal Structure of [Mo(Cl)(CO)2(PPh3)]2(η1:η2:μ‐SCNMe2)2
Authors: Wang Hsiao‐Fen , Yih Kuang‐Hway , Lee Gene‐Hsiang , Huang Shou‐Ling 
Published: October 2011

AbstractThe first doubly‐bridged thiocarbamoyl metal complex [Mo(Cl)(CO)2(PPh3)]2(η1:η2:μ‐SCNMe2)2 (2) was formed from stirring [Mo(CO)2(η2‐SCNMe2)(PPh3)2Cl] (1) in dichloromethane at room temperature. Complex 2 is a dimer with each thiocarbamoyl unit coordinating through sulfur and carbon to one metal center and bridging both metals through sulfur. Complex 2 is characterized by X‐ray diffraction analysis.
Synthesis, Structure and Solvatochromism Studies on Copper(II) Complexes Containing Ethylenediamine, Pyridine and Imidazol Ligands
Authors: Golchoubian Hamid , Nazari Omeleila , Kariuki Benson 
Published: October 2011

AbstractTwo copper(II) complexes type [Cu(en)X2](ClO4)2, where en = ethylenediamine and X = pyridine, 1 or imidazol, 2 have been synthesized and prepared on the bases of elemental analysis, spectroscopic and molar conductance measurements. The X‐ray crystal analysis of these complexes demonstrated that the copper(II) ions are in square planar environments through coordination by two nitrogen atoms of the ethylenediamine and two nitrogen atoms of two pyridine or imidazol molecules and the ClO4‐ ions are bound weakly above and below of the molecular plane. The complexes show three ions behavior in all solvents. The complexes are soluble in various solvents and are solvatochromic. The solvatochromism of the complexes were investigated by UV‐Vis spectroscopy with different solvent parameters such as DN, AN, α and β using multiple linear regression (MLR) method. The results suggested that the DN parameter of the solvent has the most contribution to the shift of the d‐d absorption band of the complex 1 but in complex 2 the DN and β have almost similar importance in the observed variation in the shift of the νmax values with solvent nature.
A New Combination Strategy as Applied in Predicting Chromatographic Retention Times of Oligonucleotides at a Range of Temperatures from 30 °C to 80 °C
Authors: Liang Gui‐Zhao , Ma Xiu‐Yan , Chen Yu‐Zhen , Li Yuan‐Chao , Lv Feng‐Li , Yang Li 
Published: October 2011

AbstractWe develop a new combination strategy to predict retention times of oligonucleotides in ion‐pair reversed‐phase high performance liquid chromatography. The key step of the strategy is to use score of generalized base properties (SGBP) combined with auto cross covariance (ACC) to resolve the feature representation of nucleic acids. This representation characterize physicochemical, quantumchemical, topological, spatial structural features, etc., and their neighboring effect between bases at a certain distance apart in a sequence. The next step is to use the variables selected by genetic algorithm (GA) to construct prediction models of retention times of oligonucleotides based on support vector machine (SVM). Accordingly, GA‐SVM models give different prediction performance using different input descriptors resulting from different step lengths in the ACC transformation, indicating the neighboring effect between bases should not be neglected in the features related to the chromatographic retention of oligonucleotides. As a whole, the GA‐SVM predictors obtained from more than 20 training samples can produce satisfying performance in predicting the chromatographic retention of oligonucleotides at a range of temperatures (30 °C, 40 °C, 50 °C, 60 °C and 80 °C), respectively. The present approach based on the SGBP‐ACC‐GA‐SVM combination shows great application prospect in the field of separation and analysis science, bioinformatics and proteomics.
Relationship between soil temperature and fruit colour development of ‘Clemenpons’ Clementine mandarin (Citrus clementina Hort ex. Tan)
Authors: Mesejo Carlos , Gambetta Giuliana , Gravina Alfredo , Martinez‐Fuentes Amparo , Reig Carmina , Agusti Manuel 
Published: October 2011

AbstractBACKGROUND: In Citrus, root temperature regulates rind colouration. However, few studies have investigated the range of temperatures and timing which determine rind colour break. The objective of this study was to determine the relationship between range of soil temperature (ST) and rind colour development in the precocious ‘Clemenpons’ Clementine mandarin. Reflective white plastic mulch was used to modify root temperature.RESULTS: Mulching increased reflected light and reduced daily maximum ST and temperature range, major differences being established 70–30 days before harvest. Rind colour‐break correlated positively with 20 °C < ST < 23 °C; thus, 20–23 °C appears to be the ST threshold interval for fruit colouration. The sooner the soil reached it, the sooner the fruit changed rind colour. In our experiments, control trees accumulated 565 h at this ST interval before fruit changed colour, whereas in treated trees it occurred 2 weeks earlier. Hence, in treated trees the colour break was advanced by 2 weeks and this increased the percentage of fruit harvested at the first picking date by up to 2.5‐fold.Conclusions: Fruit colour‐break does not take place at a certain ST, but after several hours at a ST of 20–23 °C. In our experiments, reducing ST during the 2 months before harvest advances the first picking date in the ‘Clemenpons’ Clementine mandarin. Copyright © 2011 Society of Chemical Industry
Comparative study on protein cross‐linking and gel enhancing effect of microbial transglutaminase on surimi from different fish
Authors: Chanarat Sochaya , Benjakul Soottawat , H‐Kittikun Aran 
Published: October 2011

AbstractBACKGROUND: Microbial transglutaminase (MTGase) has been used to increase the gel strength of surimi. Nevertheless, its effectiveness varies with fish species. The aim of this study was to elucidate the effect of MTGase at different levels on protein cross‐linking and gel property of surimi from threadfin bream, Indian mackerel and sardine in the presence and absence of endogenous transglutaminase.RESULT: Breaking force of all surimi gels increased as MTGase levels (0–0.6 U g−1) increased except for threadfin bream surimi gel, where the breaking force decreased at 0.6 U g−1 (P < 0.05). In the presence of EDTA, the gel strengthening effect was lower, suggesting the combined effect of endogenous transglutaminase with MTGase. With the addition of MTGase, the gel with the highest increase in breaking force showed highest decrease in myosin heavy chain. When cross‐linking activity of MTGase on natural actomyosin (NAM) was determined, the highest decreasing rate in ε‐amino group content with the concomitant increased formation of cross‐linked proteins was found in NAM from threadfin bream. The reactivity of muscle proteins toward MTGase‐induced cross‐linking was in agreement with surimi gel strengthening.CONCLUSION: The composition and properties of muscle proteins of varying fish species more likely determined protein cross‐linking induced by MTGase, thereby affecting their gel properties. Copyright © 2011 Society of Chemical Industry
Effects of cinnamon leaf, oregano and sweet orange essential oils on fermentation and aerobic stability of barley silage
Authors: Chaves Alexandre V , Baah John , Wang Yuxi , McAllister Tim A , Benchaar Chaouki 
Published: October 2011

AbstractBACKGROUND: Silage additives are marketed with the primary aim of improving the fermentation and/or aerobic stability of silage. The objective of this study was to evaluate the impact of three different essential oils (EOs; cinnamon leaf (CIN), oregano (ORE) and sweet orange (SO)) on the fermentation characteristics and stability of barley silage. Chopped whole‐plant barley (Hordem vulgare L.) forage was ensiled either untreated (0 mg kg−1 dry matter (DM)) or treated with CIN, ORE or SO (37.5, 75 and 120 mg kg−1 DM).RESULTS: Moulds were not detected in any treatments, including the control, after 7 days of air exposure. All EOs at a concentration of 120 mg kg−1 silage DM decreased (P = 0.001) yeast populations in comparison with the control during air exposure. Net gas, methane and ammonia concentrations in vitro did not differ among treatments. Changes in volatile fatty acid concentrations were small, and in situ data showed no changes in DM and neutral detergent fibre digestion rates for CIN, ORE or SO at concentrations up to 120 mg kg−1 DM.CONCLUSION: The findings from this study show that a concentration of 120 mg EO kg−1 DM decreased yeast counts during aerobic stability tests. However, all EO treatments had minimal effects on data from in vitro and in situ incubations. Copyright © 2011 Crown in the right of Canada. Published by JohnWiley & Sons, Ltd
Postprandial inflammatory response in adipose tissue of patients with metabolic syndrome after the intake of different dietary models
Authors: Meneses Maria E. , Camargo Antonio , Perez‐Martinez Pablo , Delgado‐Lista Javier , Cruz‐Teno Cristina , Jimenez‐Gomez Yolanda , Paniagua Juan A. , Gutierrez‐Mariscal Francisco M. , Tinahones Francisco J. , Vidal‐Puig Antonio , Roche Helen M. , Perez‐Jimenez Francisco , Malagon Maria M. , Lopez‐Miranda Jose 
Published: October 2011

AbstractScope: Dysfunctional adipose tissue may be an important trigger of molecular inflammatory pathways that cause cardiovascular diseases. Our aim was to determine whether the specific quality and quantity of dietary fat produce differential postprandial inflammatory responses in adipose tissue from metabolic syndrome (MetS) patients.Methods and results: A randomized, controlled trial conducted within the LIPGENE study assigned MetS patients to 1 of 4 diets: (i) high‐saturated fatty acid (HSFA), (ii) high‐monounsaturated fatty acid (HMUFA), (iii) low‐fat, high‐complex carbohydrate diet supplemented with n−3 polyunsaturated fatty acids (PUFA) (LFHCC n−3), and (iv) low‐fat, high‐complex carbohydrate diet supplemented with placebo (LFHCC), for 12 wk each. A fat challenge reflecting the fatty acid composition as the original diets was conducted post‐intervention. We found that p65 gene expression is induced in adipose tissue (p=0.003) at the postprandial state. In addition, IκBα (p<0.001), MCP‐1 (p<0.001) and IL‐1β (p<0.001) gene expression was equally induced in the postprandial state, regardless of the quality and quantity of the dietary fat. Notably, IL‐6 transcripts were only detected in the postprandial state.Conclusions: Our results indicate that individuals with MetS typically exhibit exacerbated adipose tissue postprandial inflammatory responses, which seem to be independent of the quality and quantity of dietary fat.
Vascular deconjugation of quercetin glucuronide: The flavonoid paradox revealed?
Authors: Menendez Carmen , Dueñas Montserrat , Galindo Pilar , González‐Manzano Susana , Jimenez Rosario , Moreno Laura , Zarzuelo Maria José , Rodríguez‐Gómez Isabel , Duarte Juan , Santos‐Buelga Celestino , Perez‐Vizcaino Francisco 
Published: October 2011

AbstractScope: The dietary flavonoid quercetin exerts protective cardiovascular effects. Because quercetin is rapidly metabolized into less active or inactive glucuronidated metabolites and the plasma concentrations of free quercetin are very low, a huge amount of scientific data generated along decades with the unconjugated compounds in vitro has been questioned. We aimed to determine whether glucuronidated quercetin can deconjugate in situ and whether deconjugation leads to a biological effect.Methods and results: Quercetin and quercetin‐3‐O‐glucuronide (Q3GA) were perfused through the isolated rat mesenteric vascular bed. Quercetin was rapidly metabolized in the mesentery. In contrast, the decay of Q3GA was slower and was accompanied by a progressive increase of quercetin in the perfusate and in the tissue over 6 h, which was prevented by the β‐glucuronidase inhibitor saccharolactone. Incubation of mesenteric arterial rings mounted in a wire myograph with Q3GA for ≥1 h resulted in a significant inhibition of the contractile response which was also prevented by saccharolactone. Moreover, the intravenous administration of Q3GA resulted in a slow onset and sustained blood pressure lowering effect, demonstrating for the first time that Q3GA has effects in vivo.Conclusion: We propose that Q3GA behaves as a quercetin carrier in plasma, which deconjugates in situ releasing the aglycone which is the final effector.
Resveratrol in human cancer chemoprevention – Choosing the ‘right’ dose
Authors: Scott Edwina , Steward William P. , Gescher Andreas J. , Brown Karen 
Published: October 2011

AbstractThere is now robust preclinical evidence to suggest that resveratrol possesses cancer chemopreventive properties. A series of clinical pilot studies has provided insights into its pharmacokinetics, and data on its human antineoplastic pharmacodynamics start to emerge. It is likely that resveratrol will be developed further in the clinic as a putative cancer chemopreventive agent. The question that remains unresolved is: What is the most suitable dose of resveratrol for effective cancer preventive intervention? Mechanistic studies in cells in vitro have almost invariably used concentrations of resveratrol in the 10–5 to 10–4 M range, which is much higher than those which can be achieved in the human biophase after consumption of doses up to 1 g. Many of the preclinical efficacy studies in rodent models of carcinogenesis have employed doses which are dramatically above those which can be ingested with the diet. New experimental paradigms need to be used to obtain information on pharmacological changes elicited by resveratrol when present at very low concentrations or when administered at dietary‐relevant doses.
Impact of Participation in a Theatre Programme on Quality of Life among Older Adults with Chronic Conditions: A Pilot Study
Authors: Yuen Hon Keung , Mueller Kris , Mayor Ellise , Azuero Andres 
Published: October 2011

AbstractThe purpose of this mixed methods study was to evaluate the effect of participation in the “Seasoned Arts At the Samford for You” (SAASY) programme, which included a 6‐week acting class and four public performances, on the psychological well‐being and health‐related quality of life of older adults. Twelve older adults with chronic conditions from a low‐income senior apartment and a senior living community participated in the programme. The acting class, led by two professional artists, met for a 2‐hour class weekly for six weeks. Participants completed the General Well‐being Schedule (GWBS) and the 36‐Item Short‐Form Health Survey (SF‐36) both at the beginning of the programme and one month after the programme ended. In addition, participants were individually interviewed to explore the perceived impact of the theatre programme on their well‐being. Participants reported a significantly higher score in the GWBS and on the physical but not on the mental component summary of the SF‐36 at post‐SAASY programme. Content analysis of the interview transcripts revealed that participants attained an improved sense of self‐worth and self‐advocacy and overcame self‐imposed limitations. Results showed improvement in psychological well‐being and health‐related quality of life, most notably in the physical health component of SF‐36 after participating in the programme. Practice implications for occupational therapists using drama as a creative leisure occupation to promote health among older adults with chronic conditions may involve analysis of participants' occupational profile, identification of deficit areas and adaptation of the acting programme content to meet specific needs and goals.The present study used a pretest and post test one group design that has numerous inherent limitations that affect the ability to make valid inferences from study findings. A more rigorous research design with a wait‐listed control group and collection of outcome measures immediately after the acting class as well as at three months follow‐up is essential in validating the present findings. Outcome measures used in future studies to evaluate the health benefits of a theatre programme should focus on ameliorating the effects of disease on disability (such as functional mobility, everyday cognitive function and activities of daily living) in addition to prevention. Copyright © 2011 John Wiley & Sons, Ltd.
Sublytic C5b‐9 complexes induce proliferative changes of glomerular mesangial cells in rat Thy‐1 nephritis through TRAF6‐mediated PI3K‐dependent Akt1 activation
Authors: Qiu Wen , Zhang Yan , Liu Xiaomei , Zhou Jianbo , Li Yan , Zhou Ying , Shan Kai , Xia Mei , Che Nan , Feng Xuefeng , Zhao Dan , Wang Yingwei 
Published: October 2011

AbstractThe proliferation of glomerular mesangial cells (GMCs) and secretion of extracellular matrix (ECM) in rat Thy‐1 nephritis (Thy‐1N), resembling human mesangioproliferative glomerulonephritis (MsPGN), have been studied for many years, but the mechanisms, especially the role of signalling pathway activation and its regulation in GMCs triggered by sublytic C5b‐9 complexes in Thy‐1N rats remain largely unclear. In the study, the proliferation of GMCs and production of ECM as well as the role of PI3K/Akt and its regulation, both in GMCs induced by sublytic C5b‐9 (in vitro) and in the renal tissues of rats with Thy‐1N (in vivo), were determined and the results revealed that GMCs proliferation and ECM secretion, both in vitro and in vivo, were notably increased, and that PI3K/Akt1 activation and its regulation, such as TNF receptor‐associated factor 6 (TRAF6)‐mediated Akt1 ubiquitination and PI3K‐dependent Akt1 phosphorylation, were involved in the process of Thy‐1N induction. On the other hand, silence of the TRAF6, PI3K or Akt1 genes could obviously diminish the proliferative damages and urinary protein secretion of Thy‐1N rats. Together, these data implicated that sublytic C5b‐9 complexes in Thy‐1N rats could promote GMCs proliferation and ECM production through TRAF6‐mediated PI3K‐dependent Akt1 activation, in which the ubiquitination and phosphorylation of the Akt1 signal molecule played an important role in the initiation and development of the proliferative changes in the rats with Thy‐1N. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Cytokinesis, ploidy and aneuploidy
Authors: Lacroix Benjamin , Maddox Amy Shaub 
Published: October 2011

AbstractCytokinesis is the last step of cell division that physically separates the daughter cells. As such, it ensures the proper inheritance of both nuclear and cytoplasmic contents. Accomplishment of cytokinesis in eukaryotes is dictated by several key events: establishment of the division plane, furrow ingression through contraction of an actomyosin ring and abscission via membrane fusion. Most mammalian somatic cells are diploid. Polyploidy can result from cytokinesis failure and may contribute to the development of pathologies such as cancer. However, polyploidy is essential for cellular differentiation and function in some contexts (eg hepatocytes, megakaryocytes and others). Consequently, the degree of ploidy and the achievement of cytokinesis must be tightly regulated throughout an organism and among different cell types. In this review we will highlight several examples of normal and pathological polyploidy, focusing on those caused by a controlled failure or dysregulation of cytokinesis, respectively. Last, we propose therapeutic routes to control cytokinesis to restore or block cell division. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.