bluuebunny/crossref_metadata_2025_split huggingface dataset:
An examination of corporate social responsibility and financial performance
Authors: Oeyono Juanita , Samy Martin , Bampton Roberta 
Published: May 2011

PurposeThe increasing demand of stakeholders' interests in social performance has put pressure on corporations to undertake social responsibility reporting in their operations in order to satisfy the demands and to gain public support. Some organisations have already responded, either by publishing a separate report regarding their social activities, or by providing such information in their annual report or on their web site. However, in some developing countries such as Indonesia, there is little or no regulation and with no expectation to follow international standards, corporations in these countries tend not to provide corporate social responsibility (CSR) reports. As there is a lack of regulatory controls in reporting CSR activities in most developing countries, the question of what the “carrot” is for the corporations is the crux of this research. The purpose of this paper is to investigate whether Indonesian corporations are aware of CSR.Design/methodology/approachThis research aims to investigate the level of CSR conducted by the top 50 corporations in Indonesia based on Global Reporting Initiative (GRI) guidelines, as well as to investigate the relationship between CSR and profitability. The profitability variables chosen are earnings before interest, tax, depreciation and amortisation (EBITDA) and earnings per share (EPS). The GRI guidelines have been chosen for this study to be used as a basis to measure corporations' social responsibility activities. The dataset was based on the years 2003‐2007, and the data collected in 2008.FindingsThis study showed that Indonesian corporations are already aware of the increasing demands and provide CSR information to stakeholders in the emerging economy. The CSR reporting measured as per the GRI indicated that five out of 45 corporations (11 per cent) completed a maximum of six GRI indicators, ten corporations (22 per cent) fulfilled five indicators and 16 corporations (36 per cent) complied with four indicators. The analyses revealed that there is a positive relationship between CSR and profitability, although it is weak (18 per cent for EBITDA and 16 per cent for EPS). Therefore, it can be argued that reporting social responsibility activities is beneficial for corporations in emerging economies such as Indonesia.Originality/valueFrom the literature, the authors have concluded that there is no research evidence of a study that analyses the depth or level of CSR reporting among Indonesian corporations, hence there is a contribution to new knowledge as the analysis reveals new findings in relation to a developing country. Although there are studies measuring the relationship between CSR reporting and financial performance such as EPS, this study further explores the correlation by introducing a new variable, i.e. EBITDA.
The evolution and development of arts marketing research
Authors: Fillis Ian 
Published: May 2011

PurposeThe purpose of this paper is to carry out a longitudinal review of arts marketing research.Design/methodology/approachThe paper looks back at the origins of arts marketing research, identifying the initial areas of interest and traces its development as a recognised research domain.FindingsArts marketing research has evolved from being an application of marketing using long‐held principles into a discipline where critical and creative approaches are now being used to generate more meaningful and actionable arts marketing theory.Research limitations/implicationsAlthough arts marketing research has developed in terms of rigour, depth and reach, there is still much unexplored potential to be realised.Practical implicationsThe paper shows that effective arts marketing consists of a balance of addressing artistic needs and customer expectations. The marketing involved must acknowledge the merits of artistic philosophy, while also addressing the commercial realities of today's arts world.Originality/valueOnly a very small number of assessments of the state of arts marketing knowledge have been carried out. The paper develops both a longitudinal analysis of the origins and growth of this knowledge and provides suggestions for future research.
Mapping the arts marketing literature
Authors: O'Reilly Daragh 
Published: May 2011

PurposeThe purpose of this paper is to visually map the arts marketing journal literature.Design/methodology/approachAn extensive title and abstract search was carried out to identify literature on the relationship between art and the market. Papers were then classified by topic. Visual maps were drawn showing topic coverage in relevant areas.FindingsThe literature dealing with the relationship between art and the market is found to be extensive and multi‐disciplinary. The search found just over 1,500 papers.Research limitations/implicationsThis was a mapping exercise rather than an analysis of the issues. Many different disciplines have a stake in understanding the art‐market relationship. Arts marketing scholars can benefit from engaging with research in this area, which is outside the marketing academy.Practical implicationsThe maps provide a visual guide to the work, which has already been done across a wide range of disciplines and journals. They enable academic and professional readers to see where knowledge and insights may already exist and where work remains to be done.Originality/valueGiven the recent growth in arts marketing research, the paper provides a timely map of the territory.
Profiling the expression of interleukin (IL)‐28 and IL‐28 receptor α in systemic lupus erythematosus patients
Authors: Lin Shih‐Chang , Kuo Chia‐Chen , Tsao Jeng‐Ting , Lin Li‐Jing 
Published: May 2011

Eur J Clin Invest 2012; 42 (1): 61–69AbstractBackground  Interleukin (IL)‐28 is an interferon‐λ‐family member involved in immunity against viral infection and tumour. We here determined the expression profiles of IL‐28 and IL‐28 receptor α (IL‐28RA) in patients with systemic lupus erythematosus (SLE) to evaluate the possibility that IL‐28 is linked to the pathogenesis of SLE.Materials and methods  The serum IL‐28 protein levels were determined by ELISA, and the IL‐28 and IL‐28RA transcript levels in peripheral blood mononuclear cells (PBMCs) and peripheral blood T cells were determined by RT‐PCR. The levels in patients with SLE with the active disease activity were statistically compared with those in normal controls.Results  IL‐28 protein in sera and IL‐28 transcripts in PBMCs and unactivated T cells were detectable only in some individuals, and IL‐28 transcripts in T cells were induced by cell activation with anti‐CD2, anti‐CD3 and anti‐CD28 antibodies. However, compared with normal controls, patients with SLE more frequently had detectable IL‐28 protein in serum and had the higher IL‐28 transcript levels in activated CD4+ T cells, but not activated CD8+ T cells. Two IL‐28RA transcripts isoforms were detected in PBMCs and T cells, and their levels in patients with SLE were comparable with those in normal controls.Conclusions  The expression of IL‐28, a T‐cell autocrine factor, is dysregulated in patients with SLE, supporting the possibility that IL‐28 may contribute to some of the SLE pathogenesis.
Dietary intake, nutritional status and rehabilitation outcomes of stroke patients in hospital
Authors: Nip W. F. R. , Perry L. , McLaren S. , Mackenzie A. 
Published: May 2011

AbstractBackground:  Nutrition affects rehabilitation through its influence on physical and mental functioning, although little attention has been paid to effects on rehabilitation outcomes. The present study aimed to describe nutritional status and food consumption in stroke patients within 2 weeks of hospital admission and before discharge, as well as to investigate the effects of nutritional and dietary factors on rehabilitation outcomes.Methods:  One hundred patients from a consecutive cohort admitted to a metropolitan hospital with acute stroke were recruited and assessed by a single researcher, with 38 reassessed at discharge. Nutritional status was assessed using Mini‐Nutritional Assessment and anthropometric indices and dietary intake was assessed by 1‐day weighed dietary records. Rehabilitation outcomes were changes in Barthel index scores and the rehabilitation efficiency index.Results:  Few (n = 9; 10%) consumed ≥100% of the estimated average requirement (EAR) for energy within 2 weeks of admission and 13 (33%) had energy intakes <50% of EAR before discharge. A small but increasing proportion (7% at admission, 13% at discharge) were identified as being malnourished across the inpatient stay. Younger age, lower Barthel index and a higher energy intake in the early stages of admission predicted the extent and rate of restoration of functional abilities by discharge (F = 7.503, P = 0.001; F = 14.558, P < 0.001).Conclusions:  Given a general finding of nutritional deterioration identified for these patients, as well as the identification of energy intake as a modifiable influence on the extent and rate of recovery, there is clearly scope for the multidisciplinary development of nutritional support for stroke patients to improve rehabilitation outcomes.
The value of DNA sequence data for studying landscape genetics
Authors: BOHONAK ANDREW J. , VANDERGAST AMY G. 
Published: May 2011

AbstractIn a recent Opinion article in Molecular Ecology, Wang (2010) emphasizes the fact that current patterns of genetic differentiation among populations reflect processes that have acted over temporal scales ranging from contemporary to ancient. He draws a sharp distinction between the fields of phylogeography (as the study of historical processes) and landscape genetics (which he restricts to very recent processes). Wang characterizes DNA sequence data as being inappropriate for the study of contemporary population processes and further states that studies which only include mitochondrial DNA or chloroplast DNA data cannot be considered part of landscape genetics. In this response, we clarify the generally accepted view that DNA sequence data can be analysed with methods that separate contemporary and historical processes. To illustrate this point, we summarize the study of Vandergast et al. (2007), which Wang mischaracterizes as being confused in terms of temporal scale. Although additional focus should be placed on the important issue of correct data interpretation, we disagree strongly with the implication that contemporary and historic processes cannot be separated in the analyses of DNA sequence data.
Depressive symptoms and quality of life in people with age‐ related macular degeneration
Authors: Mathew Remy Sheena , Delbaere Kim , Lord Stephen R , Beaumont Paul , Vaegan  , Madigan Michele C 
Published: May 2011

Citation information: Mathew RS, Delbaere K, Lord SR, Beaumont P, Vaegan & Madigan MC. Depressive symptoms and quality of life in people with age‐ related macular degeneration. Ophthalmic Physiol Opt 2011, 31, 375–380. doi: 10.1111/j.1475‐1313.2011.00848.xAbstractPurpose:  To examine quality of life and associated factors in people with Age‐Related Macular Degeneration (AMD).Methods:  One hundred and forty‐five AMD participants (mean age 78.0 ± 7.7 years) and 104 age‐ and gender‐ matched controls (mean age 78.1 ± 5.8 years) comprised the study populations for this case‐control study. Depressive symptoms were measured with the Goldberg Anxiety and Depression (GAD) scale; general health and daily functioning was assessed with the Medical Outcomes Study Short Form 36 (SF‐36) and questions relating to assistance required for daily living activities.Results:  People with AMD performed more poorly than controls on the GAD depression scale, and physical functioning subscale of SF‐36. 44.4% of people with AMD had clinically significant depressive symptoms compared to 17.5% of controls (p < 0.001). Multiple regression analysis revealed that AMD was independently associated with depressive symptoms and a path model indicated that AMD led to depressive symptoms both directly and indirectly via reduced general health and social functioning.Conclusion:  Psychological and functional outcome measures are reduced in people with AMD. Earlier recognition and treatment of depressive symptoms in people with AMD may be crucial to maintaining quality of life in this group.
Early transcriptional pattern of angiogenesis induced by EGCG treatment in cervical tumour cells
Authors: Tudoran Oana , Soritau Olga , Balacescu Ovidiu , Balacescu Loredana , Braicu Cornelia , Rus Meda , Gherman Claudia , Virag Piroska , Irimie Florin , Berindan‐Neagoe Ioana 
Published: May 2011

AbstractThe major green tea polyphenol (‐)‐epigallocatechin‐3‐gallate (EGCG) has been shown to exhibit antitumour activities in several tumour models. One of the possible mechanisms by which EGCG can inhibit cancer progression is through the modulation of angiogenesis signalling cascade. The tumour cells’ ability to tightly adhere to endothelium is a very important process in the metastatic process, because once disseminated into the bloodstream the tumour cells must re‐establish adhesive connections to endothelium in order to extravasate into the target tissues. In this study, we investigated the anti‐angiogenic effects of EGCG treatment (10 μM) on human cervical tumour cells (HeLa) by evaluating the changes in the expression pattern of 84 genes known to be involved in the angiogenesis process. Transcriptional analysis revealed 11 genes to be differentially expressed and was further validated by measuring the induced biological effects. Our results show that EGCG treatment not only leads to the down‐regulation of genes involved in the stimulation of proliferation, adhesion and motility as well as invasion processes, but also to the up‐regulation of several genes known to have antagonist effects. We observed reduced proliferation rates, adhesion and spreading ability as well as invasiveness of HeLa tumour cells upon treatment, which suggest that EGCG might be an important anti‐angiogenic therapeutic approach in cervical cancers.
Differential LEF1 and TCF4 expression is involved in melanoma cell phenotype switching
Authors: Eichhoff Ossia M. , Weeraratna Ashani , Zipser Marie C. , Denat Laurence , Widmer Daniel S. , Xu Mai , Kriegl Lydia , Kirchner Thomas , Larue Lionel , Dummer Reinhard , Hoek Keith S. 
Published: May 2011

SummaryRecent observations suggest that melanoma cells drive disease progression by switching back and forth between phenotypic states of proliferation and invasion. Phenotype switching has been linked to changes in Wnt signalling, and we therefore looked for cell phenotype‐specific differences in the levels and activity of β‐catenin and its LEF/TCF co‐factors. We found that while cytosolic β‐catenin distribution is phenotype‐specific (membrane‐associated in proliferative cells and cytosolic in invasive cells), its nuclear distribution and activity is not. Instead, the expression patterns of two β‐catenin co‐factors, LEF1 and TCF4, are both phenotype‐specific and inversely correlated. LEF1 is preferentially expressed by differentiated/proliferative phenotype cells and TCF4 by dedifferentiated/invasive phenotype cells. Knock‐down experiments confirmed that these co‐factors are important for the phenotype‐specific expression of M‐MITF, WNT5A and other genes and that LEF1 suppresses TCF4 expression independently of β‐catenin. Our data show that melanoma cell phenotype switching behaviour is regulated by differential LEF1/TCF4 activity.
Meta-Analysis and Functional Validation of Nutritional Requirements of Solventogenic Clostridia Growing under Butanol Stress Conditions and Coutilization ofd-Glucose andd-Xylose
Authors: Heluane Humberto , Evans Matthew R. , Dagher Sue F. , Bruno-Bárcena José M. 
Published: May 2011

ABSTRACTRecent advances in systems biology, omics, and computational studies allow us to carry out data mining for improving biofuel production bioprocesses. Of particular interest are bioprocesses that center on microbial capabilities to biotransform both the hexose and pentose fractions present in crop residues. This called for a systematic exploration of the components of the media to obtain higher-density cultures and more-productive fermentation operations than are currently found. By using a meta-analysis approach of the transcriptional responses to butanol stress, we identified the nutritional requirements of solvent-tolerant strainClostridium beijerinckiiSA-1 (ATCC 35702). The nutritional requirements identified were later validated using the chemostat pulse-and-shift technique.C. beijerinckiiSA-1 was cultivated in a two-stage single-feed-stream continuous production system to test the proposed validated medium formulation, and the coutilization ofd-glucose andd-xylose was evaluated by taking advantage of the well-known ability of solventogenic clostridia to utilize a large variety of carbon sources such as mono-, oligo-, and polysaccharides containing pentose and hexose sugars. Our results indicated thatC. beijerinckiiSA-1 was able to coferment hexose/pentose sugar mixtures in the absence of a glucose repression effect. In addition, our analysis suggests that the solvent and acid resistance mechanisms found in this strain are differentially regulated compared to strain NRRL B-527 and are outlined as the basis of the analysis toward optimizing butanol production.
Engineering Escherichia coli BL21(DE3) Derivative Strains To Minimize E. coli Protein Contamination after Purification by Immobilized Metal Affinity Chromatography
Authors: Robichon Carine , Luo Jianying , Causey Thomas B. , Benner Jack S. , Samuelson James C. 
Published: May 2011

ABSTRACT

Recombinant His-tagged proteins expressed in
Escherichia coli
and purified by immobilized metal affinity chromatography (IMAC) are commonly coeluted with native
E. coli
proteins, especially if the recombinant protein is expressed at a low level. The
E. coli
contaminants display high affinity to divalent nickel or cobalt ions, mainly due to the presence of clustered histidine residues or biologically relevant metal binding sites. To improve the final purity of expressed His-tagged protein, we engineered
E. coli
BL21(DE3) expression strains in which the most recurring contaminants are either expressed with an alternative tag or mutated to decrease their affinity to divalent cations. The current study presents the design, engineering, and characterization of two
E. coli
BL21(DE3) derivatives, NiCo21(DE3) and NiCo22(DE3), which express the endogenous proteins SlyD, Can, ArnA, and (optionally) AceE fused at their C terminus to a chitin binding domain (CBD) and the protein GlmS, with six surface histidines replaced by alanines. We show that each
E. coli
CBD-tagged protein remains active and can be efficiently eliminated from an IMAC elution fraction using a chitin column flowthrough step, while the modification of GlmS results in loss of affinity for nickel-containing resin. The “NiCo” strains uniquely complement existing methods for improving the purity of recombinant His-tagged protein.
Monitoring the Wet-Heat Inactivation Dynamics of Single Spores of Bacillus Species by Using Raman Tweezers, Differential Interference Contrast Microscopy, and Nucleic Acid Dye Fluorescence Microscopy
Authors: Zhang Pengfei , Kong Lingbo , Wang Guiwen , Setlow Peter , Li Yong-qing 
Published: May 2011

ABSTRACT

Dynamic processes during wet-heat treatment of individual spores of
Bacillus cereus
,
Bacillus megaterium
, and
Bacillus subtilis
at 80 to 90°C were investigated using dual-trap Raman spectroscopy, differential interference contrast (DIC) microscopy, and nucleic acid stain (SYTO 16) fluorescence microscopy. During spore wet-heat treatment, while the spores' 1:1 chelate of Ca
2+
with dipicolinic acid (CaDPA) was released rapidly at a highly variable time
T
lag
, the levels of spore nucleic acids remained nearly unchanged, and the
T
lag
times for individual spores from the same preparation were increased somewhat as spore levels of CaDPA increased. The brightness of the spores' DIC image decreased by ∼50% in parallel with CaDPA release, and there was no spore cortex hydrolysis observed. The lateral diameters of the spores' DIC image and SYTO 16 fluorescence image also decreased in parallel with CaDPA release. The SYTO 16 fluorescence intensity began to increase during wet-heat treatment at a time before
T
lag
and reached maximum at a time slightly later than
T
release
. However, the fluorescence intensities of wet-heat-inactivated spores were ∼15-fold lower than those of nutrient-germinated spores, and this low SYTO 16 fluorescence intensity may be due in part to the low permeability of the dormant spores' inner membranes to SYTO 16 and in part to nucleic acid denaturation during the wet-heat treatment.
Influence of the Drilling Mud Formulation Process on the Bacterial Communities in Thermogenic Natural Gas Wells of the Barnett Shale
Authors: Struchtemeyer Christopher G. , Davis James P. , Elshahed Mostafa S. 
Published: May 2011

ABSTRACT

The Barnett Shale in north central Texas contains natural gas generated by high temperatures (120 to 150°C) during the Mississippian Period (300 to 350 million years ago). In spite of the thermogenic origin of this gas, biogenic sulfide production and microbiologically induced corrosion have been observed at several natural gas wells in this formation. It was hypothesized that microorganisms in drilling muds were responsible for these deleterious effects. Here we collected drilling water and drilling mud samples from seven wells in the Barnett Shale during the drilling process. Using quantitative real-time PCR and microbial enumerations, we show that the addition of mud components to drilling water increased total bacterial numbers, as well as the numbers of culturable aerobic heterotrophs, acid producers, and sulfate reducers. The addition of sterile drilling muds to microcosms that contained drilling water stimulated sulfide production. Pyrosequencing-based phylogenetic surveys of the microbial communities in drilling waters and drilling muds showed a marked transition from typical freshwater communities to less diverse communities dominated by
Firmicutes
and
Gammaproteobacteria
. The community shifts observed reflected changes in temperature, pH, oxygen availability, and concentrations of sulfate, sulfonate, and carbon additives associated with the mud formulation process. Finally, several of the phylotypes observed in drilling muds belonged to lineages that were thought to be indigenous to marine and terrestrial fossil fuel formations. Our results suggest a possible alternative exogenous origin of such phylotypes via enrichment and introduction to oil and natural gas reservoirs during the drilling process.