bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scalp metastasis from atypical meningioma: A case report and literature review
Authors: Javed Saad , Khan Amina , Khalid Ayesha , Scalia Gianluca , Umana Giuseppe Emmanuele , Mahmood Ashraf , Yaqoob Eesha , Pahwa Bhavya , Chaurasia Bipin 
Published: April 2024

Key Clinical MessageScalp metastasis from atypical meningioma, though rare, underscores the importance of meticulous surgical techniques to prevent tumor cell implantation. Early detection and comprehensive management, including surgery and adjuvant therapy, are crucial for optimal outcomes.AbstractMeningiomas are tumors of the meninges that originate in the arachnoid layer from arachnoid cap cells. Atypical meningiomas, classified as WHO grade 2 tumors, tend to metastasize and recur if not surgically managed properly. Scalp metastasis is a rare occurrence that presents as a subcutaneous elevation. A 33‐year‐old patient presented with a complaint of a constant, dull pressure headache persisting for the past 12 months, exacerbated by exertion, along with seizures and neuropsychiatric symptoms. The patient had no significant medical history but had undergone surgery 4 years ago for a WHO grade 2 meningioma. The current brain MRI revealed a dural tail sign, along with masses on both the left and right sides of the frontal lobe, extending to involve the skin on the forehead and scalp. The patient underwent surgical resection and adjuvant radiation therapy. At the 12‐month follow‐up, no neurological deterioration or tumor recurrence was observed. A literature review on scalp metastasis in patients with atypical meningioma was also conducted, including eight articles published up to September 2023. The mechanism of metastasis development appears to be consistent in all eight reported cases, involving the implantation of tumor cells during resection. Therefore, there is a critical need for meticulous intra‐ and post‐operative surgical techniques to prevent such implantation.
Aggregatibacter actinomycetemcomitans pacemaker lead infection—A case report and literature review
Authors: Zhang Hayden , Sivalingam Varsha , Qian Pierre , Sivagnanam Shobini 
Published: April 2024

Key Clinical MessageAggregatibacter spp. is a rare cause for cardiac device infections. Due to limited data, the management of Aggregatibacter spp. device infections is not clearly defined but should always involve device removal and prolonged intravenous antibiotics.
Monitoring fatigue state with heart rate‐based and subjective methods during intensified training in recreational runners
Authors: Nuuttila Olli‐Pekka , Uusitalo Arja , Kokkonen Veli‐Pekka , Weerarathna Nilushika , Kyröläinen Heikki 
Published: April 2024

AbstractThe purpose of this study was firstly to examine the sensitivity of heart rate (HR)‐based and subjective monitoring markers to intensified endurance training; and secondly, to investigate the validity of these markers to distinguish individuals in different fatigue states. A total of 24 recreational runners performed a 3‐week baseline period, a 2‐week overload period, and a 1‐week recovery period. Performance was assessed before and after each period with a 3000m running test. Recovery was monitored with daily orthostatic tests, nocturnal HR recordings, questionnaires, and exercise data. The participants were divided into subgroups (overreached/OR, n = 8; responders/RESP, n = 12) based on the changes in performance and subjective recovery. The responses to the second week of the overload period were compared between the subgroups. RESP improved their baseline 3000 m time (p < 0.001) after the overload period (−2.5 ± 1.0%), and the change differed (p < 0.001) from OR (0.6 ± 1.2%). The changes in nocturnal HR (OR 3.2 ± 3.1%; RESP −2.8 ± 3.7%, p = 0.002) and HR variability (OR −0.7 ± 1.8%; RESP 2.1 ± 1.6%, p = 0.011) differed between the subgroups. In addition, the decrease in subjective readiness to train (p = 0.009) and increase in soreness of the legs (p = 0.04) were greater in OR compared to RESP. Nocturnal HR, readiness to train, and exercise‐derived HR‐running power index had ≥85% positive and negative predictive values in the discrimination between OR and RESP individuals. In conclusion, exercise tolerance can vary substantially in recreational runners. The results supported the usefulness of nocturnal HR and subjective recovery assessments in recognizing fatigue states.
Exploring the anti‐inflammatory ingredients and potential of golden buckwheat (Fagopyrum dibotrys) on the TLR4/NLRP3 pathway in acute lung injury
Authors: Hu Yingfan , Liu Xiaomin , Song Yu , Zhang Yan , Li Wei , Zhang Lele , Wang Anqi , Su Qian , Yang Zhiyong , Zou Liang 
Published: April 2024

AbstractGolden buckwheat, also called Fagopyrum dibotrys (D. Don) H. Hara, is a plant of the genus Buckwheat in the buckwheat family. The aim of this study was to screen the bioactive ingredients of golden buckwheat extract and investigate the protective effect on acute lung injury (ALI). The ethyl acetate extract (EAE) was identified as the active fraction in LPS‐induced RAW264.7 cells, with gallic acid, proanthocyanidin B2, and epicatechin at 0.0563%, 0.3707%, and 0.3868%, respectively. At the same time, 20 compounds (mainly flavonoids and organic acids) were identified by UPLC‐Q‐Exactive Orbitrap‐HRMS in EAE. Furthermore, the EAE reduced lung histopathology scores in mice with ALI, decreased the dry‐to‐wet weight ratio of lung tissue, and significantly inhibited the concentrations of IL‐1β, TNFα, and IL‐6 in bronchoalveolar lavage fluid (BALF). It also reduced the number of leukocytes, decreased the activity of MPO in lung tissue, and inhibited the levels of TLR4/NLRP3 pathway mRNA and protein in lung tissue. Our study indicated that golden buckwheat as a source of functional food prevents or treats associated lung diseases by modulating the activation of the TLR4/NLRP3 signaling pathway.
Climate risks and the REITs market
Authors: Salisu Afees A. , Ogbonna Ahamuefula E. , Vo Xuan Vinh 
Published: April 2024

AbstractThis study presents results supporting the need to price climate risks in real estate investment trusts. We approach this objective by conducting some empirical analyses for global, regional, and [US] sectoral REITs for want of wider coverage while we also consider variants of climate risks involving physical and transition risks. We first establish that climate concerns amplify the volatility of REIT returns. While our results are split for sectoral REITs, we find that both physical and transition risks magnify the volatility in the regional and global REITs market. However, when we consider the US sectoral REITs, we find contrasting evidence between the two variants of climate risks. While the transition risks seem to raise the REITs market volatility, perhaps owing to improved trading in the market as signalled by some level commitments towards addressing climate change, the physical risks associated with damages due to climate change tend to lower the REITs market volatility due to lower trading. Consequently, we formulate a framework that enables a profit‐maximizing investor to observe climate risks when making investment decisions in the REITs market, and we further show that doing so provides higher economic gains than ignoring it. This outcome has implications for investors looking for the best hedging strategy against climate‐related risks, especially as the world intensifies efforts towards de‐carbonization.
Association between adenomyosis and placenta accreta and mediation effect of assisted reproductive technology on the association: A nationwide observational study
Authors: Wada Yoshimitsu , Takahashi Hironori , Ogoyama Manabu , Horie Kenji , Suzuki Hirotada , Usui Rie , Jwa Seung Chik , Ohkuchi Akihide , Fujiwara Hiroyuki 
Published: April 2024

AbstractObjectivesTo investigate the association between adenomyosis and placenta accreta spectrum (PAS) and to evaluate the effect of assisted reproductive technology (ART) in mediating this association.MethodsWe retrieved data for singleton women from the Japanese nationwide perinatal registry between 2013 and 2019, excluding women with a history of adenomyomectomy. To investigate the association between adenomyosis and PAS among women, we used a multivariable logistic regression model with multiple imputation for missing data. We evaluated mediation effect of ART including in vitro fertilization and intracytoplasmic sperm injection on the association between adenomyosis and PAS using causal mediation analysis based on the counterfactual approach.ResultsOf 1 500 173 pregnant women, 1539 (0.10%) had adenomyosis. The number receiving ART was 489/1539 (31.8%) and 117 482/1 498 634 (7.8%) in women with and without adenomyosis, respectively. The proportion of women who developed PAS was 21/1539 (1.4%) in women with adenomyosis and 7530/1 498 634 (0.5%) in women without adenomyosis. Adenomyosis was significantly associated with PAS (odds ratio [OR] 1.95; 95% confidence interval [CI] 1.26–3.00; P = 0.002). Mediation analysis showed that OR of the total effect of adenomyosis on PAS was 1.98 (95% CI 1.13–3.04), OR of natural indirect effect (effect explained by ART) was 1.15 (95% CI 1.01–1.41), and OR of natural direct effect (effect unexplained by ART) was 1.72 (95% CI 0.86–2.82). The proportion mediated (natural indirect effect/total effect) was 26.5%. Adenomyosis was also significantly associated with PAS without previa (OR 1.96; 95% CI 1.23–3.13, P = 0.005).ConclusionAdenomyosis was significantly associated with PAS. ART mediated 26.5% of the association between adenomyosis and PAS.
Conjunctive use of floodwater harvesting for managed aquifer recharge and irrigation on a date farm in Morocco
Authors: Khardi Yassine , Lacombe Guillaume , Dewandel Benoit , Hammani Ali , Taky Abdelilah , Bouarfa Sami 
Published: April 2024

AbstractIn arid regions, harvesting floodwater can mitigate irrigation‐induced groundwater depletion by providing additional surface water and recharging aquifers. We designed an experimental protocol to quantify these fluxes on a date farm located along the Wadi Satt, whose flow originates from the Anti‐Atlas Mountains in south‐eastern Morocco. Automatic barometric sensors were used to monitor the water level in a 6500 m3 floodwater harvesting pond and in surrounding boreholes. Six flood events occurred from 2021 to 2023. The pond water balance indicated that most stored water is pumped for irrigation (56% of harvested floodwater). More than 40% infiltrates at a rate of approximately 90 mm day−1, and the remainder evaporated. Analytical modelling of the pond water table system showed that the radius of the piezometric mound resulting from pond infiltration is less than 360 m. Groundwater recharge from the irrigated plot could be observed after two close floods that enabled continuous pumping for several weeks, suggesting that in this specific context, over‐irrigation using surface water allows the aquifer to be recharged. The hydrological effects of possible future expansion of these ponds at the watershed scale should be analysed to assess possible negative impacts on downstream water resources.
Clinical outcomes of patients receiving three versus four doses of methotrexate with concomitant antithymocyte globulin in match unrelated donor allogeneic stem cell transplant: A single‐center experience
Authors: Poonsombudlert Kittika , Mott Sarah , Miller Benda , Yodsuwan Ratdanai , Shaikh Hira , Strouse Christopher , Lochner Jonathan , Farooq Umar , Magalhaes‐Silverman Margarida 
Published: April 2024

AbstractMethotrexate (MTX) doses on days +1, +3, +6, and +11 after match unrelated donor allogeneic stem cell transplant (MUD HSCT) is a common graft‐versus‐host disease (GVHD) prophylaxis regimen. However, the overlapping toxicity of MTX with conditioning chemotherapy sometimes warrants the omission of the fourth dose of MTX. Prior single‐institution studies showed conflicting results comparing the outcomes of patients who received three versus four doses of MTX, but to our knowledge, the effect of concomitant antithymocyte globulin (ATG) has not been reported. Charts of patients who underwent MUD HSCT between 2009 and 2023 were reviewed. Patients received rabbit ATG (Thymoglobulin), given at 0.5 mg/kg on day −3, 2 mg/kg on day −2, and 2.5 mg/kg on day −1. MTX is given at 15 mg/m2 on day +1 and 10 mg/m2 on days +3, +6, and +11. Severe mucositis was the most common indication for day +11 MTX omission (82%). We identified 292 patients (116 in 3 dose cohort and 176 in 4 dose cohort). Median follow‐up was 23 months (range 1–151). Patients in the 4 doses cohort were more frequently male (68% vs. 50%, p < 0.01), received a reduced intensity conditioning regimen (38.0% vs. 22%, p < 0.01), were older (median 58 vs. 54 years, p = 0.02), and received a transplant in the earlier era (median HSCT year 2014 vs. 2018, p < 0.01). A statistically significant difference was not evidenced between the cohorts for the following outcomes: acute GVHD (aGVHD) (HR 1.1, 95% CI 0.9–1.5), chronic GVHD (cGVHD) (HR 1.3, 95% CI 0.8–1.6), relapse‐free survival (RFS) (HR 1.0, 95% CI 0.6–1.5), non‐relapse mortality (NRM) (HR 1.4, 95% CI 0.9–2.2), and overall survival (OS) (HR 1.2, 95% CI 0.9–1.7). Both cohorts had similar median time to neutrophil engraftment at 14 days. When ATG is incorporated, omission of day +11 MTX does not significantly impact the rate of engraftment or cumulative incidence of aGVHD, cGVHD, RFS, NRM, and OS.
Impact of the COVID‐19 pandemic on the productivity and career prospects of musculoskeletal researchers
Authors: Chakraborty Lauren S. , Le Maitre Christine L. , Chahine Nadeen O. , Fields Aaron J. , Gawri Rahul , Giers Morgan B. , Smith Lachlan J. , Tang Simon Y. , Zehra Uruj , Haglund Lisbet , Samartzis Dino , Martin John T. 
Published: April 2024

AbstractAcademic researchers faced a multitude of challenges posed by the COVID‐19 pandemic, including widespread shelter‐in‐place orders, workplace closures, and cessation of in‐person meetings and laboratory activities. The extent to which these challenges impacted musculoskeletal researchers, specifically, is unknown. We developed an anonymous web‐based survey to determine the pandemic's impact on research productivity and career prospects among musculoskeletal research trainees and faculty. There were 116 musculoskeletal (MSK) researchers with varying demographic backgrounds who completed the survey. Of respondents, 48.3% (n = 56) believed that musculoskeletal funding opportunities decreased because of COVID‐19, with faculty members more likely to hold this belief compared to nonfaculty researchers (p = 0.008). Amongst MSK researchers, 88.8% (n = 103) reported research activity was limited by COVID‐19, and 92.2% (n = 107) of researchers reported their research was not able to be refocused on COVID‐19‐related topics, with basic science researchers less likely to be able to refocus their research compared to clinical researchers (p = 0.030). Additionally, 47.4% (n = 55) reported a decrease in manuscript submissions since the onset of the pandemic. Amongst 51 trainee researchers, 62.8% (n = 32) reported a decrease in job satisfaction directly attributable to the COVID‐19 pandemic. In summary, study findings indicated that MSK researchers struggled to overcome challenges imposed by the pandemic, reporting declines in funding opportunities, research productivity, and manuscript submission. Trainee researchers experienced significant disruptions to critical research activities and worsening job satisfaction. Our findings motivate future efforts to support trainees in developing their careers and target the recovery of MSK research from the pandemic stall.
The influence of sex is a neglected focus in rotator cuff repair: A systematic review and meta‐analysis
Authors: Monteleone Andrea Stefano , Salerno Manuela , Mondini Trissino da Lodi Camilla , Gonalba Giorgia Carlotta , Candrian Christian , Filardo Giuseppe 
Published: April 2024

AbstractPurposeRotator cuff (RC) disorders are the most common cause of shoulder disability. The aim of this study was to quantify the evidence on the sex‐related differences in RC repair.MethodsA systematic review of the literature was performed in January 2023 in PubMed, Wiley Cochrane Library and Web of Science on research articles on humans with RC tears treated surgically. A meta‐analysis was performed to compare results in men and women. The Downs and Black score and the modified Coleman methodology score (MCMS) were used to assess the retrieved studies.ResultsA total of 39,909 patients were enroled in the 401 studies analysed (45% women, 55% men). A trend toward more sex‐balanced recruitment was observed over time. Only 4% of the studies on 1.5% of the documented patients presented disaggregated outcome data and were quantitatively analysed. A tendency for lower range of motion values after surgery was found for external shoulder rotation in women, with 39.9° ± 6.9° versus 45.3° ± 4.1° in men (p = 0.066). According to Downs and Black scores, four studies were good and 12 fair, with a main MCMS score of 69/100.ConclusionThere is a lack of awareness on the importance to document women‐ and men‐specific data. Only 4% of the articles disaggregated data, and it was possible to analyse only 1.5% of the literature population, a sample which cannot be considered representative of all patients. The lack of disaggregated data is alarming and calls for action to better study men and women differences to optimise the management of RC tears. This will be necessary to provide sex‐specific information that could be of clinical relevance when managing RC repair.Level of EvidenceLevel IV.
Robotic Neck Dissection in Head and Neck Cancer via Modified BABA Technique
Authors: Dabas Surendra K. , Menon Nandini N. , Tiwari Sukirti , Shukla Himanshu , Ranjan Reetesh , Gurung Bikas , Bassan Bharat B. , Kapoor Rahul , Verma Vinay , Sharma Pankaj , Verma Devesh , Sharma Ashwani 
Published: April 2024

IntroductionNeck dissection forms an important component in the surgical management of head and neck cancers. By using the conventional techniques of neck dissection, a conspicuous scar is inevitable for the patients. The development of robotic assisted neck dissection provides for a scar‐free neck along with good oncological and functional outcomes.MethodsA prospective observational study was conducted in our institute from 2020 March to 2022 March, where robotic‐assisted neck dissections performed via the modified bilateral axillo‐breast insufflation technique.ResultsEighty‐two patients underwent robotic neck dissections in our institute. Notably, 79 patients were treatment‐naïve. The average docking time was 12 min and console time was 160 ± 15 min. The mean lymph node yield was 28.2. The average post‐operative stay was 5.6 days. The average follow‐up was noted to be 6.4 months. The mean cosmetic satisfaction score in our patients was 4.45. Only one patient presented with nodal recurrence, who was identified as a defaulter for adjuvant treatment. Robotic neck dissection gives similar functional and oncological outcomes as compared with conventional neck dissection. Patients had excellent cosmetic satisfaction following the procedure. The limitations of these techniques include high cost of procedure and longer operating time. This is a level IV evidence study.ConclusionAlthough good oncological, functional, and cosmetic outcomes have been attained in robotic assisted neck dissection, further randomized controlled studies need to be conducted to justify the added costs, cosmetic advantage, and the time taken.Level of EvidenceIV Laryngoscope, 134:4045–4051, 2024
Modern machine‐learning applications in ambient ionization mass spectrometry
Authors: Sorokin Anatoly A. , Pekov Stanislav I. , Zavorotnyuk Denis S. , Shamraeva Mariya M. , Bormotov Denis S. , Popov Igor A. 
Published: April 2024

AbstractThis article provides a comprehensive overview of the applications of methods of machine learning (ML) and artificial intelligence (AI) in ambient ionization mass spectrometry (AIMS). AIMS has emerged as a powerful analytical tool in recent years, allowing for rapid and sensitive analysis of various samples without the need for extensive sample preparation. The integration of ML/AI algorithms with AIMS has further expanded its capabilities, enabling enhanced data analysis. This review discusses ML/AI algorithms applicable to the AIMS data and highlights the key advancements and potential benefits of utilizing ML/AI in the field of mass spectrometry, with a focus on the AIMS community.
A chimeric adenovirus‐vectored vaccine based on Beta spike and Delta RBD confers a broad‐spectrum neutralization against Omicron‐included SARS‐CoV‐2 variants
Authors: Hong Weiqi , Lei Hong , Peng Dandan , Huang Yuhe , He Cai , Yang Jingyun , Zhou Yanan , Liu Jian , Pan Xiangyu , Que Haiying , Alu Aqu , Chen Li , Ai Jiayuan , Qin Furong , Wang Binhan , Ao Danyi , Zeng Zhen , Hao Ying , Zhang Yu , Huang Xiya , Ye Chunjun , Fu MinYang , He Xuemei , Bi Zhenfei , Han Xuejiao , Luo Min , Hu Hongbo , Cheng Wei , Dong Haohao , Lei Jian , Chen Lu , Zhou Xikun , Wang Wei , Lu Guangwen , Shen Guobo , Yang Li , Yang Jinliang , Li Jiong , Wang Zhenling , Song Xiangrong , Sun Qiangming , Lu Shuaiyao , Wang Youchun , Cheng Ping , Wei Xiawei 
Published: April 2024

AbstractUrgent research into innovative severe acute respiratory coronavirus‐2 (SARS‐CoV‐2) vaccines that may successfully prevent various emerging emerged variants, particularly the Omicron variant and its subvariants, is necessary. Here, we designed a chimeric adenovirus‐vectored vaccine named Ad5‐Beta/Delta. This vaccine was created by incorporating the receptor‐binding domain from the Delta variant, which has the L452R and T478K mutations, into the complete spike protein of the Beta variant. Both intramuscular (IM) and intranasal (IN) vaccination with Ad5‐Beta/Deta vaccine induced robust broad‐spectrum neutralization against Omicron BA.5‐included variants. IN immunization with Ad5‐Beta/Delta vaccine exhibited superior mucosal immunity, manifested by higher secretory IgA antibodies and more tissue‐resident memory T cells (TRM) in respiratory tract. The combination of IM and IN delivery of the Ad5‐Beta/Delta vaccine was capable of synergically eliciting stronger systemic and mucosal immune responses. Furthermore, the Ad5‐Beta/Delta vaccination demonstrated more effective boosting implications after two dosages of mRNA or subunit recombinant protein vaccine, indicating its capacity for utilization as a booster shot in the heterologous vaccination. These outcomes quantified Ad5‐Beta/Delta vaccine as a favorable vaccine can provide protective immunity versus SARS‐CoV‐2 pre‐Omicron variants of concern and BA.5‐included Omicron subvariants.
Innovative pathological network‐based multitarget approaches for Alzheimer's disease treatment
Authors: Mayo Paloma , Pascual Jorge , Crisman Enrique , Domínguez Cristina , López Manuela G. , León Rafael 
Published: April 2024

AbstractAlzheimer's disease (AD) is the most prevalent neurodegenerative disease and is a major health threat globally. Its prevalence is forecasted to exponentially increase during the next 30 years due to the global aging population. Currently, approved drugs are merely symptomatic, being ineffective in delaying or blocking the relentless disease advance. Intensive AD research describes this disease as a highly complex multifactorial disease. Disclosure of novel pathological pathways and their interconnections has had a major impact on medicinal chemistry drug development for AD over the last two decades. The complex network of pathological events involved in the onset of the disease has prompted the development of multitarget drugs. These chemical entities combine pharmacological activities toward two or more drug targets of interest. These multitarget‐directed ligands are proposed to modify different nodes in the pathological network aiming to delay or even stop disease progression. Here, we review the multitarget drug development strategy for AD during the last decade.