bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sparus Docking Station: A current aware docking station system for a non‐holonomic AUV
Authors: Esteba Joan , Cieślak Patryk , Palomeras Narcís , Ridao Pere 
Published: April 2024

AbstractThis paper presents the design and development of a funnel‐shaped Sparus Docking Station intended for the non‐holonomic torpedo‐shaped Sparus II Autonomous Underwater Vehicle. The Sparus Docking Station is equipped with sensors and batteries, allowing for a stand‐alone long‐term deployment of the vehicle. An inverted Ultra Short Base‐Line system is used to locate the Docking Station as well as to provide long‐term drift‐less vehicle navigation. The Sparus Docking Station is able to observe the ocean currents using a Doppler Velocity Log, being motorized to allow its self‐alignment with the current. Moreover, a docking algorithm accounting for the current is used to guide the robot during the docking maneuver. The paper reports consecutive successful experimental results of the docking maneuver in sea trials in two different countries.
Impact of Mg‐doping on morphology, structure, optical properties, and enhancing photocatalytic performance of ZnO thin films, prepared by sol–gel spin‐coated method
Authors: Tusher Md Mahamud Hasan , Mirza Golam Murtaza , Jabed Akib , Imam Alisan , Kabhi Ahsanul Alam , Sakib Nazmus , Islam Md. Naymul 
Published: April 2024

AbstractThin films of pure and Mg‐doped ZnO (MZO) were successfully fabricated on glass substrates by sol–gel spin coating method. Microstructure, surface morphology, elemental composition, optical analysis, and Mg doping effect on the photocatalytic performance of the thin films have been measured by XRD, SEM, EDS, and UV–Vis, respectively. XRD analysis showed that ZnO and MZO thin films have a hexagonal wurtzite structure, and the intensity of the (0 0 2) peak moved from higher to lower angle and right to left with rising Mg‐dopant concentration, and crystallinity was enhanced with doping, whereas micro‐strain and dislocation density dropped. SEM analysis found that ZnO had spherical and agglomerated structures, and the increased size of the grains was observed with increasing doping. The optical analysis demonstrated that the band gaps increased as the dopant percentage increased. Methylene blue, a dye pollutant, examined the thin films’ photocatalytic performance. It was demonstrated that the addition of the Mg to the ZnO lattices increased the absorption of the hydroxyl ions at the surface of the thin film and hence acted as a trap site, leading to a decrease in the electron–hole pair and consequently enhancing the photodegradation.
Detection of selected antimicrobial residues in red meat and kidney of beef cattle slaughtered at Nekemte municipal abattoir, Ethiopia
Authors: Abdeta Debela , Tafesse Mathewos , Bacha Balachew 
Published: April 2024

AbstractBackgroundAntibiotics are commonly used drugs in farm animals for therapeutic, prophylactic and diagnosis purposes. As a result of the use of antibiotics in livestock, residues of antibiotics may be present in animal‐derived foods, especially in meat. This study aimed at determining the antibiotic residues in cattle slaughtered at Nekemte municipal abattoir and assessing the knowledge, attitude and practice (KAP) level of the community about antibiotic residue in food of cattle origin.Materials and methodsA cross‐sectional study was conducted on randomly selected kidney and muscle samples slaughtered at Nekemte municipal abattoir. The samples were collected aseptically and analysed using liquid chromatography mass spectrometer. In addition the KAP of cattle handlers, butcher men and meat users were collected using structured questionnaire. The data was analysed by SPSS and intercooled Stata version 7.0, 2001.ResultsResults are presented as percentages and frequency distributions in tabular and graphical form. From 120 individuals interviewed, only 25.83% knew about withdrawal time and had limited knowledge on effect of antibiotic residue on human health, whereas about 47.5% did not heard about antibiotic residue in meat. Tetracycline was detected in all the sampled meat 60 (100%), whereas oxytetracycline residues were detected in half 15 (50%) of the samples. In the current study doxycycline, sulphadiazine, penicillin G and enrofloxacin were not detected in all samples. Oxytetracycline residue levels ranged from 0.00 to 463.35 µg/kg for the kidney and 0.00 to 354.55 µg/kg for muscle samples. About 10% of kidney and 3.33% muscle samples collected had oxytetracycline residues above maximum residue limits.ConclusionIn general, the study revealed that oxytetracycline residues were prevalent among antimicrobial residues analysed from the study area. The study indicated the presence of high antimicrobial residue and hence exposes for antimicrobial resistance of pathogens warranting coordinated effort to mitigate its health effect on the animal and hence human being.
Metal Ion and Metal‐to‐Ligand Ratio Regulated Construction of Cu(II) and Co(II) Coordination Polymers as Efficient Catalysts for Ring‐Opening Polymerization of L‐Lactide
Authors: Tao Jin‐Xia , Wei Mei‐Jun , Tian Feng , Xia Zhen‐Xiang , Huang Kun‐Lin , Qian Jun‐Feng , He Ming‐Yang , Chen Sheng‐Chun , Chen Qun 
Published: April 2024

AbstractThree new coordination polymers (CPs), {[Cu(NDC)(Fbtx)(H2O)] ⋅ 1.5H2O}n (1), {[Co(NDC)(Fbtx)(H2O)2] ⋅ 0.5Fbtx}n (2), and [Co2(NDC)2(Fbtx)]n (3), were synthesized by employing acid‐base mixed ligands of rigid 1,4‐naphthalenedicarboxylic acid (H2NDC) and flexible bis(1,2,4‐triazole‐1‐ylmethyl)‐2,3,5,6‐tetrafluorobenzene (Fbtx) under both hydrothermal and microwave‐assisted reaction conditions. Single‐crystal structure analysis establishted that both compounds 1 and 2 exhibit two‐dimensional (2D) layered structures, while compound 3 features a three‐dimensional (3D) complicated framework. The geometries of metal ions vary from square pyramidal (in 1 and 3) to distorted octahedral (in 2). Topological strudy showed that compounds 1 and 2 have exposed common 4‐connected 44‐sql net, while compound 3 has made a novel 4,5‐connected net with point symbol of (43 ⋅ 62 ⋅ 7)(43 ⋅ 64 ⋅ 72 ⋅ 8). The catalytic performance of the three complexes for the solvent‐free ring‐opening polymerization of L‐lactide has been investigated. The results indicated that compound 3 with coordinatively unsaturated cobalt(II) sites showed good activity and the molecular weight of the polymer obtained was high. Moreover, the complex 3 catalyst could be recycled up to five times with the retention of both catalytic activity and crystal structure.
Telomerase is essential for cardiac differentiation and sustained metabolism of human cardiomyocytes
Authors: Chatterjee Shambhabi , Leach-Mehrwald Megan , Huang Cheng-Kai , Xiao Ke , Fuchs Maximilian , Otto Mandy , Lu Dongchao , Dang Vinh , Winkler Thomas , Dunbar Cynthia E. , Thum Thomas , Bär Christian 
Published: April 2024

AbstractTelomeres as the protective ends of linear chromosomes, are synthesized by the enzyme telomerase (TERT). Critically short telomeres essentially contribute to aging-related diseases and are associated with a broad spectrum of disorders known as telomeropathies. In cardiomyocytes, telomere length is strongly correlated with cardiomyopathies but it remains ambiguous whether short telomeres are the cause or the result of the disease. In this study, we employed an inducible CRISPRi human induced pluripotent stem cell (hiPSC) line to silence TERT expression enabling the generation of hiPSCs and hiPSC-derived cardiomyocytes with long and short telomeres. Reduced telomerase activity and shorter telomere lengths of hiPSCs induced global transcriptomic changes associated with cardiac developmental pathways. Consequently, the differentiation potential towards cardiomyocytes was strongly impaired and single cell RNA sequencing revealed a shift towards a more smooth muscle cell like identity in the cells with the shortest telomeres. Poor cardiomyocyte function and increased sensitivity to stress directly correlated with the extent of telomere shortening. Collectively our data demonstrates a TERT dependent cardiomyogenic differentiation defect, highlighting the CRISPRi TERT hiPSCs model as a powerful platform to study the mechanisms and consequences of short telomeres in the heart and also in the context of telomeropathies.
Emergence of keystone individuals in the social networks of the ant Camponotus fellah
Authors: Kovács B. , Jordán F. 
Published: April 2024

AbstractCommunity ecology and sociobiology share a number of problems (e.g. understanding part-to-whole relationships), so sharing methods may be beneficial. In this paper, we re-analyze a large social network database for Camponotus fellah ants, from the perspective of keystone individuals, based on methods developed in community ecology. We study different network types for six colonies, over a time series of 10 days. These include the total network of weighted interactions, the subnetworks for the castes and the subnetworks for Queen-linked and Queen-independent individuals. We perform time-independent (i.e. average values) and temporal (i.e. trends) analyses. The most commonly used global network metrics showed high variability in time but no clear trends. Yet, the variability of a network centrality index (topological importance, TI), developed earlier in community ecology, shows clear increase in each colony over time, suggesting the emergence of keystone individuals as a general tendency in all studied ant colonies.
A newly developed algorithm for switching outpatient medications to medications listed in the hospital formulary: a prospective real-word evaluation in patients admitted electively to hospital
Authors: Möller Finja , Oetting Malte , Spiegel Andreas , Zube Olaf , Bertsche Thilo 
Published: April 2024

Abstract
Purpose
In many countries, outpatient and inpatient care are separated. During hospitalization, therefore, switching the outpatient medication to medication of the hospital formulary is required.

Methods
We newly designed a switching algorithm in six switching steps (S0–S5) and conducted a study at Bundeswehr Hospital Hamburg (300 beds, 80% civilians). We performed (i) a medication reconciliation to obtain information on outpatient medications and (ii) a medication review to solve drug-related-problems, e.g., drug-drug interactions. We applied (iii) the algorithm to switch medications to the hospital formulary.

Results
(i) We identified 475 outpatient medications (median per patient: 4; Q25/Q75 2/7) in 100 patients consecutively admitted to hospital (median age: 71; Q25/Q75: 64/80 years). Of 475 medications, the switching algorithm could not be used since product names were missing in 23.9% and strength in 1.7%. In 3.2%, switching was not required since medication was not prescribed during the hospital stay. (ii) Drug-drug interactions were identified in 31 of 79 patients with more than one medication. (iii) Of 475 medications, 18.5% were on the hospital formulary and therefore did not need to be switched (S0), 0.2% were on a substitution-exclusion list not allowing switching (S1), 42.0% were switched to a generic medication of the hospital formulary (S2), 1.7% to a therapeutically equivalent medication (S3), 0.4% were patient-individually switched (S4), and for 8.2% a standardized/patient-individual switching was not possible (S5).

Conclusions
Despite comprehensive medication reconciliation, patient- and medication-related information for switching medications to the hospital formulary was often missing. Once all the necessary information was available, standardized switching could be easily carried out according to a newly developed switching algorithm.
Extremal Graph Theoretic Questions for q-Ary Vectors
Authors: Patkós Balázs , Tuza Zsolt , Vizer Máté 
Published: April 2024

AbstractA q-graph H on n vertices is a set of vectors of length n with all entries from $$\{0,1,\dots ,q\}$$

{
0
,
1
,
⋯
,
q
}

and every vector (that we call a q-edge) having exactly two non-zero entries. The support of a q-edge $${\textbf{x}}$$
x
is the pair $$S_{\textbf{x}}$$

S
x

of indices of non-zero entries. We say that H is an s-copy of an ordinary graph F if $$|H|=|E(F)|$$

|
H
|
=
|
E
(
F
)
|

, F is isomorphic to the graph with edge set $$\{S_{\textbf{x}}:{\textbf{x}}\in H\}$$

{

S
x

:
x
∈
H
}

, and whenever $$v\in e,e'\in E(F)$$

v
∈
e
,

e
′

∈
E

(
F
)

, the entries with index corresponding to v in the q-edges corresponding to e and $$e'$$

e
′

sum up to at least s. E.g., the q-edges (1, 3, 0, 0, 0), (0, 1, 0, 0, 3), and (3, 0, 0, 0, 1) form a 4-triangle. The Turán number $$\mathop {}\!\textrm{ex}(n,F,q,s)$$

ex
(
n
,
F
,
q
,
s
)

is the maximum number of q-edges that a q-graph H on n vertices can have if it does not contain any s-copies of F. In the present paper, we determine the asymptotics of $$\mathop {}\!\textrm{ex}(n,F,q,q+1)$$

ex
(
n
,
F
,
q
,
q
+
1
)

for many graphs F.
Pediatric blood cultures—turning up the volume: a before and after intervention study
Authors: Whelan Seán Olann , Mulrooney Conor , Moriarty Frank , Cormican Martin 
Published: April 2024

AbstractThe major determinant of blood culture (BC) diagnostic performance is blood volume, and pediatric sample volumes are frequently low. We aimed to assess BC volumes in our institution, design an intervention to increase volumes, and assess its impact. All pediatric BCs submitted over a 7-month period to the microbiology laboratory in a university hospital (including emergency department, pediatric ward, and neonatal unit) were included. A pre-intervention period assessed current practice. A multi-faceted intervention (education, guideline introduction, active feedback strategies) was collaboratively designed by all stakeholders. Impact was assessed in a post-intervention period. The main outcome measures included the percentage of samples adequately filled using three measures of sample adequacy (1) manufacturer-recommended minimum validated volume—> 0.5 ml, (2) manufacturer-recommended optimal minimum volume—> 1.0 ml, (3) newly introduced age-specific recommendations. Three hundred ninety-eight pre-intervention and 388 post-intervention samples were included. Initial volumes were low but increased significantly post-intervention (median 0.77 ml vs. 1.52 ml), with multivariable regression analysis estimating volumes increased 89% post-intervention. There were significant increases in all measures of volume adequacy, including an increase in age-appropriate filling (20.4–53.1%), with less improvement in those aged > 3 years. Overall, 68.4% of pathogens were from adequately filled cultures, while 76% of contaminants were from inadequately filled cultures. A pathogen was detected in a higher proportion of adequately filled than inadequately filled cultures (9.4% vs. 2.2%, p < 0.001). Conclusion: Blood volume impacts BC sensitivity, with lower volumes yielding fewer pathogens and more contaminants. Focused intervention can significantly improve volumes to improve diagnostic performance.

What is Known:• Blood volume is the major determinant of blood culture positivity, and yet pediatric blood culture volumes are frequently low, resulting in missed pathogens and increased contamination.

What is New:• Adequately filled (for age) blood cultures have a pathogen detection rate three times higher than inadequately filled blood cultures.• This interventional study shows that collaboratively designed multi-modal interventions including focus on accurate volume measurement can lead to significant increases in blood volumes and improve blood culture diagnostic performance.
UBE2L3 expression in human gastric cancer and its clinical significance
Authors: Zhang Xiaoxia , Wei Yujie , Wu Fanqi , Li Mei , Han Cong , Huo Chengdong , Li Zhi , Tang Futian , He Wenting , Zhao Yang , Li Yumin 
Published: April 2024

Abstract
Purpose
Gastric cancer (GC) is prevalent as one of the most common malignant tumors globally, with a particularly high incidence in China. The role of UBE2L3 in the initiation and progression of various cancers has been well documented, but its specific significance in GC is not yet fully elucidated. The objective of this study is to examine the expression and importance of UBE2L3 in human gastric cancer tissues.

Methods
Immunohistochemical staining and survival analysis were conducted on 125 cases of GC. Western blot and quantitative real-time polymerase chain reaction (qRT-PCR) were employed to assess the expression of UBE2L3 in GC cell lines. Cell lines with UBE2L3 knockdown and overexpression were cultured through lentivirus transfection and subsequently assessed using Western blot analysis. The involvement of UBE2L3 in the proliferation, invasion, and apoptosis of GC cells was confirmed through in vitro experiments, and its capacity to facilitate tumor growth was also validated in in vivo studies.

Results
The up-regulation of UBE2L3 expression was observed in GC, and its high expression was found to be significantly associated with the degree of differentiation (χ2 = 6.153, P = 0.0131), TNM stage (χ2 = 6.216, P = 0.0447), and poor overall survival. In vitro, UBE2L3 has been shown to enhance functions in GC cell lines, such as promoting proliferation and invasion, and inhibiting apoptosis. In vivo experiments have validated the role of UBE2L3 in promoting tumor growth.

Conclusions
The findings of our study demonstrate the significant involvement of UBE2L3 in the pathogenesis and advancement of gastric cancer, suggesting its potential as a therapeutic target.
Determination of Nuclear Matter Radii by Means of Microscopic Optical Potentials: The Case of $$^{78}$$Kr
Authors: Vorabbi Matteo , Finelli Paolo , Giusti Carlotta 
Published: April 2024

AbstractIn this work we use microscopic Nucleon–Nucleus Optical Potentials (OP) to analyze elastic scattering data for the differential cross section of the $$^{78}$$

78

Kr (p,p) $$^{78}$$

78

Kr reaction, with the goal of extracting the matter radius and estimating the neutron skin, quantities that are both needed to determine the slope parameter L of the nuclear symmetry energy. Our analysis is performed with the factorized version of the microscopic OP obtained in a previous series of papers within the Watson multiple scattering theory at the first order of the spectator expansion, which is based on the underlying nucleon–nucleon dynamics and is free from phenomenological inputs. Differently from our previous applications, the proton and neutron densities are described with a two-parameter Fermi (2pF) distribution, which makes the extraction of the matter radius easier and allows us to make a meaningful comparison with the original analysis, that was performed with the Glauber model. With standard minimization techniques we performed data analysis and extracted the matter radius and the neutron skin. Our analysis produces a matter radius of $$R_m^{\mathrm{(rms)}} = 4.12$$

R
m

(
rms
)

=
4.12

fm, in good agreement with previous matter radii extracted from $$^{76}$$

76

Kr and $$^{80}$$

80

Kr, and a neutron skin of $$\Delta R_{np} \simeq - 0.1$$

Δ

R

np

≃
-
0.1

fm, compatible with a previous analysis. Our factorized microscopic OP, supplied with 2pF densities, is a valuable tool to perform the analysis of the experimental differential cross section and extract information such as matter radius and neutron skin. Without any free parameters it provides a reasonably good description of the experimental differential cross section for scattering angles up to $$\approx $$
≈
40 degrees. Compared to the Glauber model our OP can be applied to a wider range of scattering angles and allows one to probe the nuclear systems in a more internal region.
The effects of cerebral pressure autoregulation status and CPP levels on cerebral metabolism in pediatric traumatic brain injury
Authors: Velle Fartein , Lewén Anders , Howells Tim , Hånell Anders , Nilsson Pelle , Enblad Per 
Published: April 2024

Abstract

Background
Cerebral perfusion pressure (CPP) management in the developing child with traumatic brain injury (TBI) is challenging. The pressure reactivity index (PRx) may serve as marker of cerebral pressure autoregulation (CPA) and optimal CPP (CPPopt) may be assessed by identifying the CPP level with best (lowest) PRx. To evaluate the potential of CPPopt guided management in children with severe TBI, cerebral microdialysis (CMD) monitoring levels of lactate and the lactate/pyruvate ratio (LPR) (indicators of ischemia) were related to actual CPP levels, autoregulatory state (PRx) and deviations from CPPopt (ΔCPPopt).

Methods
Retrospective study of 21 children ≤ 17 years with severe TBI who had both ICP and CMD monitoring were included. CPP, PRx, CPPopt and ΔCPPopt where calculated, dichotomized and compared with CMD lactate and lactate-pyruvate ratio.

Results
Median age was 16 years (range 8–17) and median Glasgow coma scale motor score 5 (range 2–5). Both lactate (p = 0.010) and LPR (p =  < 0.001) were higher when CPP ≥ 70 mmHg than when CPP < 70. When PRx ≥ 0.1 both lactate and LPR were higher than when PRx < 0.1 (p =  < 0.001). LPR was lower (p = 0.012) when CPPopt ≥ 70 mmHg than when CPPopt < 70, but there were no differences in lactate levels. When ΔCPPopt > 10 both lactate (p = 0.026) and LPR (p = 0.002) were higher than when ΔCPPopt < –10.

Conclusions
Increased levels of CMD lactate and LPR in children with severe TBI appears to be related to disturbed CPA (PRx). Increased lactate and LPR also seems to be associated with actual CPP levels ≥ 70 mmHg. However, higher lactate and LPR values were also seen when actual CPP was above CPPopt. Higher CPP appears harmful when CPP is above the upper limit of pressure autoregulation. The findings indicate that CPPopt guided CPP management may have potential in pediatric TBI.
Dispersion-engineered metasurfaces for high-sensitivity color image sensors
Authors: Miyata Masashi 
Published: April 2024

AbstractIncreasing the sensitivity of image sensors is a major challenge for current imaging technology. Researchers are tackling it because highly sensitive sensors enable objects to be recognized even in dark environments, which is critical for today’s smartphones, wearable devices, and automobiles. Unfortunately, conventional image-sensor architectures use light-absorptive color filters on every pixel, which fundamentally limits the detected light power per pixel. Recent advances in optical metasurfaces have led to the creation of pixelated light-transmissive color splitters with the potential to enhance sensor sensitivity. These metasurfaces can be used instead of color filters to distinguish primary colors, and unlike color filters, they can direct almost all of the incident light to the photodetectors, thereby maximizing the detectable light power. This review focuses on such metasurface-based color splitters enabling high-sensitivity color-image sensors. Their underlying principles are introduced with a focus on dispersion engineering. Then, their capabilities as optical elements are assessed on the basis of our recent findings. Finally, it is discussed how they can be used to create high-sensitivity color-image sensors.