bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linkage Disequilibrium Under Recurrent Bottlenecks
Authors: Schaper E , Eriksson A , Rafajlovic M , Sagitov S , Mehlig B 
Published: November 2011

AbstractTo model deviations from selectively neutral genetic variation caused by different forms of selection, it is necessary to first understand patterns of neutral variation. Best understood is neutral genetic variation at a single locus. But, as is well known, additional insights can be gained by investigating multiple loci. The resulting patterns reflect the degree of association (linkage) between loci and provide information about the underlying multilocus gene genealogies. The statistical properties of two-locus gene genealogies have been intensively studied for populations of constant size, as well as for simple demographic histories such as exponential population growth and single bottlenecks. By contrast, the combined effect of recombination and sustained demographic fluctuations is poorly understood. Addressing this issue, we study a two-locus Wright–Fisher model of a population subject to recurrent bottlenecks. We derive coalescent approximations for the covariance of the times to the most recent common ancestor at two loci in samples of two chromosomes. This covariance reflects the degree of association and thus linkage disequilibrium between these loci. We find, first, that an effective population-size approximation describes the numerically observed association between two loci provided that recombination occurs either much faster or much more slowly than the population-size fluctuations. Second, when recombination occurs frequently between but rarely within bottlenecks, we observe that the association of gene histories becomes independent of physical distance over a certain range of distances. Third, we show that in this case, a commonly used measure of linkage disequilibrium, σd2 (closely related to r^2), fails to capture the long-range association between two loci. The reason is that constituent terms, each reflecting the long-range association, cancel. Fourth, we analyze a limiting case in which the long-range association can be described in terms of a Xi coalescent allowing for simultaneous multiple mergers of ancestral lines.
Beyond Silicon: Carbon-Based Nanotechnology
Authors: Guisinger Nathan P. , Arnold Michael S. 
Published: November 2011

AbstractFor more than two decades, scientists and engineers have focused on impending limitations (from high-power densities and heat distribution to device patterning) that constrain the future miniaturization of conventional silicon technology. Thus far, academic and industrial efforts have risen to the challenge and continue to advance planar silicon processing, pushing traditional microtechnology to the nanometer scale. However, insurmountable limitations, both of physical nature and cost, still loom and motivate the research of new nanomaterials and technologies that have the potential to replace and/or enhance conventional silicon systems. As time has progressed, another Group IV element has emerged as a front-runner, looking beyond silicon, in the form of carbon-based nanotechnology. The focus of this issue is to provide a comprehensive look at the state-of-the-art in carbon-based nanomaterials and nanotechnologies and their potential impact on conventional silicon technologies, which are not limited to electronics but also encompass micro- and nanoelectromechanical systems, optoelectronics, and memory. Recent advances in carbon nanotube growth, sorting, and optoelectronics will be discussed, and the relatively new and surging area of graphene research will be introduced. In addition, progress in controlling the growth and properties of ultrananocrystalline and nanocrystalline diamond thin films will be reviewed. These efforts are multidisciplinary, heavily materials focused, and tend to translate information and ideas to other carbon-based studies (e.g., graphene is the building block of carbon nanotubes).
Novel Therapeutic Strategies for Metastatic Prostate Cancer in the Post-Docetaxel Setting
Authors: Sartor Oliver , Michels Ross M. , Massard Christophe , de Bono Johann Sebastian 
Published: November 2011

Abstract
Prostate cancer is the most common noncutaneous cancer and the second leading cause of death from cancer in men in most western countries. Advanced prostate cancer is typically sensitive to androgen-deprivation therapy, but invariably progresses to the castration-resistant state. Most current prostate cancer treatments are based on cytotoxicity directed against tumor cells via androgen-deprivation therapy or chemotherapy. Chemotherapy with docetaxel represents the standard first-line treatment in patients with castration-resistant prostate cancer (CRPC). Following progression after treatment with docetaxel, cabazitaxel (XRP6258)–prednisone treatment leads to a significantly longer overall survival (OS) time than with mitoxantrone–prednisone. Several other novel agents are currently being evaluated, including sipuleucel-T, abiraterone acetate, and MDV3100, as well as the radionuclide alpharadin. The cell-based immunotherapy sipuleucel-T produces longer OS times in chemotherapy-naïve patients, whereas the androgen biosynthesis inhibitor abiraterone acetate results in longer OS times following docetaxel. It is envisioned that these agents will change the standard of care for patients with metastatic CRPC. This review focuses on the clinical development of cabazitaxel and abiraterone acetate.
The Effects of Chronic Periodontitis and Rheumatoid Arthritis on Serum and Gingival Crevicular Fluid Total Antioxidant/Oxidant Status and Oxidative Stress Index
Authors: Esen Çağrı , Alkan Banu Arzu , Kırnap Mehmet , Akgül Özgür , Işıkoğlu Semra , Erel Özcan 
Published: November 2011

Background: Chronic periodontitis (CP) and rheumatoid arthritis (RA) appear to share many pathologic features. Oxygen metabolism has an important role in the pathogenesis of both CP and RA. The aim of this study is to evaluate the relationship between these two chronic inflammatory diseases with regard to antioxidant and oxidant status.Methods: A total of 80 participants were divided into four groups of 20 each: group RA–CP (patients with RA and CP), group RA (periodontally healthy patients with RA), group CP (systemically healthy patients with CP), and group C (periodontally and systemically healthy volunteers) were included in the study. After assessment of periodontal measurements, gingival crevicular fluid (GCF) samples were taken at one incisor, premolar, and molar tooth and stored with serum samples at −80°C for the antioxidant/oxidant assay.Results: Although all clinical measurements in groups RA–CP and CP were statistically higher compared to those of C and RA groups (P <0.001), there were no differences between CP and RA–CP groups (P >0.05). GCF total oxidant status (TOS) values of CP and RA–CP groups were higher than those of the RA group (P <0.05). GCF oxidative stress index (OSI) values of the RA–CP group were higher than those of the RA group (P <0.05). There were no differences among the groups in terms of serum TOS and OSI values (P >0.05).Conclusions: Local OSI values in groups with patients with CP were higher, whereas systemic OSI values showed no difference among the groups. The presence of RA seems not to affect local and systemic OSI values in patients with CP.
Disclosures of Insider Purchases and the Valuation Implications of Past Earnings Signals
Authors: Veenman David 
Published: November 2011

ABSTRACT
This study examines whether disclosures of insider equity purchases on Securities and Exchange Commission (SEC) Form 4 resolve uncertainty regarding the valuation implications of reported earnings. Defining information uncertainty as ambiguity about firm value arising from low earnings precision, I predict and find that insider purchase filings trigger more positive market reactions in firms with greater information uncertainty (lower quality accruals). After controlling for future earnings changes, I further find that market reactions to purchase filings are predictably associated with prior earnings changes. The strength of this effect is increasing in the magnitude of insider purchases, as well as the level of information uncertainty. Overall, these findings suggest that, in addition to signaling future earnings information, Form 4 purchase filings help investors learn about the valuation implications of past earnings signals.
Data Availability: All data are available from public sources.
Accounting Decentralization and Performance Evaluation of Business Unit Managers
Authors: Indjejikian Raffi J. , Matĕjka Michal 
Published: November 2011

ABSTRACT
We use survey data to examine firms' propensity to rely on financial measures in evaluating local business unit managers. We find that firms rely less on financial measures (and more on nonfinancial measures or subjective evaluations) in determining local managers' bonuses when those managers have greater influence over the design of internal accounting systems. At the same time, we find no significant association between the choice of performance measures and local managers' authority to make operating decisions. Instead, we find that local authority to make operating decisions is positively associated with local managers' influence over accounting systems. Taken together, our findings suggest that the design of internal accounting systems is an important dimension of overall organizational design. Our findings also cast doubt on the maintained assumption in prior work that major organizational design choices are complementary.
Data Availability: Data used in this study cannot be made public due to confidentiality agreements with participating firms.
Direct and Mediated Associations among Earnings Quality, Information Asymmetry, and the Cost of Equity
Authors: Bhattacharya Nilabhra , Ecker Frank , Olsson Per M. , Schipper Katherine 
Published: November 2011

ABSTRACT
Using path analysis, we investigate the direct and indirect links between three measures of earnings quality and the cost of equity. Our investigation is motivated by analytical models that specify both a direct link and an indirect link that is mediated by information asymmetry, but do not suggest which link would be more important empirically. We measure information asymmetry as both the adverse selection component of the bid-ask spread and the probability of informed trading (PIN). For a large sample of Value Line firms during 1993–2005, we find statistically reliable evidence of both a direct path from earnings quality to the cost of equity, and an indirect path that is mediated by information asymmetry, with the weight of the evidence favoring the direct path as the more important.
Thrombocyte and Erythrocyte Indices in Sepsis and Disseminated Intravascular Coagulation
Authors: Acikgoz Serefden , Akduman Deniz , Eskici Zeynep , Can Murat , Mungan Gorkem , Guven Berrak , Comert Füsun , Sumbuloglu Vildan 
Published: November 2011

Thrombocyte and Erythrocyte Indices in Sepsis and Disseminated Intravascular CoagulationSepsis is the inflammatory response against infection. The existence of DIC during sepsis indicates a poor prognosis and coagulation abnormalities and thrombocytopenia may exist. The aim of this study was to investigate platelet and erythrocyte indices in sepsis patients with DIC and without DIC. In both groups coagulation tests, platelet count and indices, erythrocyte count and indices were retrospectively analysed. In the sepsis plus DIC patients the prothrombin time and D-dimer values were found significantly higher and fibrinogen, platelet and plateletcrit were found significantly lower than in the sepsis without DIC group. The analysis of mean platelet volume, platelet distribution width, erythrocyte count and indices revealed no significant differences between the two groups. These results showed us that the depression of bone marrow in septic patients with DIC and without DIC did not differ. The activation of the coagulation system might probably be the cause of thrombocyte depletion in DIC.
Applicability of the Impact Response Analysis Method for Reinforced Concrete Beams Mixed with Polyvinyl Alcohol Short Fibers
Authors: Bhatti A. Q. , Kishi N. , Shameem K. 
Published: November 2011

Abstract
The impact-resistant capacity of reinforced concrete (RC) structures can be rationally upgraded by mixing polyvinyl alcohol (PVA) short fibers into concrete. The static and dynamic post peak residual tensile strength of the concrete that occurs because of the bridge effects of PVA short fibers. In this paper, to establish a simple impact response analysis method for RC structures under impact loading, a method that treats PVA short fibers mixed into concrete as shell elements of PVA plates with an equivalent tensile strength to the post peak residual tensile strength of the concrete is proposed. The applicability of the method has been investigated by conducting a three-dimensional elastoplastic finite element analysis using LS-DYNA code and comparing the results with the falling-weight impact test results for RC beams. From this study, it was confirmed that the crack distributions and the failure mode of RC beams mixed with PVA short fibers can be predicted and that the effects of mixing PVA short fibers on improving the impact resistant capacity can be estimated by using the proposed numerical analysis method.
Automated Mold Heating System Using High Frequency Induction with Feedback Temperature Control
Authors: Park K. , Seo Y. S. , Sohn D. H. 
Published: November 2011

Abstract
High frequency induction heating is an efficient means of rapidly heating a mold surface by means of electromagnetic induction. It was recently applied to the rapid heating of injection molds for a range of purposes. To implement high frequency induction for rapid mold heating, the heating conditions have to be set appropriately to obtain the desired range of mold temperatures. In the present study, a rapid mold heating system is developed. It consists of a high frequency power supply, induction coils, a robot system, temperature sensors and controllers. The mold surface temperature is measured using the temperature sensors, and this data is then fed back to the controller so as to control the heating time. This fully automated induction heating system with feedback temperature control is then implemented for the injection molding of a transparent part with multiple holes, resulting in great improvement in the surface appearance as well as the optical properties of the molded part.
A Design-of-Experiment Study on the Microcellular Extrusion of Sub-critical CO2 Saturated PLA Pellets
Authors: Miller D. , Kumar V. 
Published: November 2011

Abstract
In this study we explore the use of solid-state nucleation in pellets as a means to decouple cell nucleation from cell growth in extrusion. This is achieved by feeding the extruder with gas-saturated PLA pellets. Cell nucleation occurs, similar to that of the well-studied solid-state batch foaming process, when gas-saturated pellets are crushed and heated in the feed section of the extruder. The polymer melt consequently contains the nucleated cells. Further, the gas content in the pellets provides a means to deliver a controlled amount of blowing agent for cell growth at the die exit. It was found that gas concentrations in partially desorbed pellets offers greater control of part density and foam morphology compared to that of fully saturated pellets at 2 MPa. Using Design-of-Experiment statistical methods it was found that gas concentration in the polymer was the most significant variable influencing foam density, whereas the extrudate cooling method was found to control cell size.
Model and Numerical Simulation for the Second Penetration in Water-assisted Injection Molding
Authors: Zhang S. , Cao W. , Zheng G. , Jia Z. , Shen C. 
Published: November 2011

Abstract
Unlike gas-assisted injection molding, subsequent penetration occurs on the radial direction after water displacing polymer melt in cavity due to the incompressibility and fast cooling of water in water-assisted injection molding. To simulate this second penetration, a dimensionless method was employed to simplify the governing equations for melt flow. Based on the reduced model, a formula was derived via mathematical inference to calculate the second penetration velocity and distance. In order to catch the huge temperature gradient at water-polymer interface, both polymer and water thermal conduct problems were founded and coupled at the interface. The finite element method was employed to solve the melt flow problem, and the finite difference method was used to discretize the energy equation. To verify the validity of the proposed model and algorithm, experiments were performed to measure the displacement of the water–melt interface for various melt temperatures and water pressures. The experimental results indicate that the primary penetration theory is not accurately on predicting residual wall thickness, whereas the combined primary and second penetration method significantly improve the accuracy.
Microsatellite loci in an endangered fern species, Athyrium viridescentipes (Woodsiaceae), and cross‐species amplification
Authors: Izuno Ayako , Takamiya Masayuki , Kaneko Shingo , Isagi Yuji 
Published: November 2011

• Premise of the study: Microsatellite markers were characterized in Athyrium viridescentipes, a critically endangered fern species in Japan, to investigate its genetic diversity and population structure.• Methods and Results: Fifteen microsatellite markers were developed. The 15 loci were successfully amplified in three additional Athyrium species except for one locus in A. vidalii. In A. viridescentipes, the number of alleles per locus ranged from one to five, with an average of 1.9, and the expected heterozygosity ranged from 0.00 to 0.53, with an average of 0.24.• Conclusions: These markers can be used in studies on conservation programs for A. viridescentipes as well as in further studies involving other Athyrium species.
Hibernomas: Clinicopathological Features, Diagnosis, and Treatment of 17 Cases
Authors: Mavrogenis Andreas F. , Coll-Mesa Luis , Drago Gabriele , Gambarotti Marco , Ruggieri Pietro 
Published: November 2011

Hibernomas are rare benign adipose tumors composed of brown fat cells with granular, multivacuolated cytoplasm admixed with white adipose tissue. They account for 1.6% of benign lipomatous tumors and approximately 1.1% of all adipocytic tumors. They are more common in the third and fourth decades of life. The most common location is the thigh, followed by the shoulder, back, and head and neck. Four histological types have been reported; abundant vascularity is characteristic, and atypias are rare. The treatment of choice for hibernomas is complete surgical excision. Metastases or malignant transformation have not been reported.
This article presents a series of 17 patients with hibernomas diagnosed and treated at our institution from January 1986 to December 2009. Six men and 11 women (M:F, 1:2) had a mean age of 38 years (range, 10 months to 64 years). All patients underwent surgical treatment; 14 patients had marginal and 3 had wide excision. Adjuvants such as radiation therapy, chemotherapy, or embolization were not administered for any patient. The most common symptom was a painless palpable mass, followed by a tender or painful mass; in 2 patients, the tumor was an incidental finding. The duration of symptoms ranged from 1 month to 10 years (mean, 27 months). The most common location was the thigh, followed by the buttock, scapula, and neck. The most common histological variant was the typical variant followed by the lipoma-like variant. At a mean follow-up of 5 years (range, 1–9 years), local recurrences were not observed.
Subcutaneous Anterior Transposition Versus Decompression and Medial Epicondylectomy for the Treatment of Cubital Tunnel Syndrome
Authors: Capo John T. , Jacob Glen , Maurer Robert J. , Nourbakhsh Ali , Preston Jared S. 
Published: November 2011

A review of the literature often fails to uncover the best procedure for the treatment of cubital tunnel syndrome. This article compares 2 frequently used methods (subcutaneous anterior transposition vs decompression and medial epicondylectomy) for their effectiveness in relieving both subjective and objective symptoms of cubital tunnel syndrome. Between August 1991 and October 1993, nineteen patients underwent surgical decompression by a single surgeon for ulnar neuropathy at the elbow. Factors evaluated included upper extremity range of motion, elbow valgus stress, grip strength, pinch, 2-point discrimination, and pre- and postoperative nerve conduction. A standardized questionnaire was administered to assess subjective relief of symptoms.
In the transposition group, grip strength averaged 71.2% of normal and pinch strength 86.6% of normal, and 2-point discrimination averaged 8.0 mm. The derived subjective assessment score was 23.2 of a possible 40. The average ulnar motor conduction velocity across the elbow was 50.1 m/sec preoperatively and 56.3 m/sec postoperatively. In the medial epicondylectomy group, grip strength averaged 79.5% of normal and pinch strength 81.7% of normal, and 2-point discrimination averaged 8.0 mm. The average ulnar motor conduction velocity across the elbow was 45.7 m/sec preoperatively and 55.7 m/sec postoperatively. No statistically significant difference existed between the 2 groups for the aforementioned indexes. These results do not indicate a difference between the outcomes of the patients undergoing either of the procedures. Because epicondylectomy is less technically demanding, with less soft tissue dissection of the nerve, it may be preferred over ulnar transposition.
Malignant Mixed Tumor of the Soft Tissue Occurring After Total Knee Arthroplasty
Authors: Tomoeda Miki , Yuki Michiko , Kubo Chiaki , Yoshizawa Hidenori , Kitamura Masanori , Nagata Shigenori , Hamada Kenichiro , Joyama Susumu , Araki Nobuhito , Tomita Yasuhiko 
Published: November 2011

A 70-year-old woman developed a malignant mixed tumor of the soft tissue 2 years after total knee arthroplasty. A 5×3×3-cm elastic hard tumor at the lateral side of the surgical scar was resected. The tumor showed focal infiltration into surrounding adipose and fibrous tissues, focal necrosis, and vascular infiltration. It was diagnosed as malignant. Mixed tumor, or myoepithelioma, of the soft tissue is a relatively rare tumor that was recently recognized as a disease entity; the vast spectrum of myoepithelial cell differentiation and the resultant morphologic diversity might increase the difficulty of the histological diagnosis. Postoperatively, the patient did not receive adjuvant therapy and no recurrence of the tumor was observed for 6 years. Range of motion of her left knee is −5° extension and 90° flexion; however, her activities of daily living are restricted because of general fatigue, partly due to hepatoma and chemotherapy.
Despite the increase of artificial implant use worldwide, reports of peri-implant tumor formation are rare. Although we do not know the exact mechanism of tumor genesis, we consider the fibroblast formation in the routine healing process to be a possible mechanism. Further investigation is necessary to identify coexisting factors that increase the risk of tumor formation after implantation.