bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Sonogashira Couplings of Halo‐ and Epoxy‐Halo‐exo‐Glycals: Concise Entry to Carbohydrate‐Derived Enynes.
Authors: Gomez Ana M. , Barrio Aitor , Pedregosa Ana , Uriel Clara , Valverde Serafin , Lopez J. Cristobal 
Published: September 2010

AbstractThe Sonogashira cross‐coupling reaction of monohalo‐and dihalo‐exo‐glycals affords carbohydrate‐derived enynes in a completely stereoselective manner.
ChemInform Abstract: Trifluoromethyl‐Promoted Homocamptothecins: Synthesis and Biological Activity.
Authors: Zhu Lingjian , Miao Zhenyuan , Sheng Chunquan , Guo Wei , Yao Jianzhong , Liu Wenfeng , Che Xiaoying , Wang Wenya , Cheng Pengfei , Zhang Wannian 
Published: September 2010

AbstractThe antitumor activity of the newly synthesized homocamptothecin derivatives (III) is evaluated in vitro and in vivo against several solid tumor cell lines.
ChemInform Abstract: Synthesis and Antitumor Activity of Novel 2′,3′‐Diethanethio‐2′,3′,5′‐trideoxy‐5′‐triazolonucleoside Analogues.
Authors: Yu Jin‐Lan , Wu Qin‐Pei , Zhang Qing‐Shan , Xi Xiao‐Dong , Liu Ning‐Ning , Li Yun‐Zheng , Liu Yan‐Hong , Yin Hong‐Quan 
Published: September 2010

AbstractA series of novel triazoloribonucleosides (VII) is synthesized by the route described for the preparation of derivative (VI) and evaluated for antitumor activity.
ChemInform Abstract: An Aryne Route to Cytosporone B and Phomopsin C.
Authors: Yoshida Hiroto , Morishita Takami , Ohshita Joji 
Published: September 2010

AbstractThe aryne insertion reaction into a carbon‐carbon σ‐bond is demonstrated to be an useful approach for the total synthesis of octaketides, allowing cytosporone B (VI) to be synthesized in six steps.
ChemInform Abstract: New 6‐Amino‐[1,2,4]triazolo[3,4‐b][1,3,4]thiadiazines and [1,2,4]Triazolo[3,4‐b][1,3,4]thiadiazin‐6‐ones: Synthesis, Characterization and Antibacterial Activity Evaluation.
Authors: Almajan Gabriela Laura , Barbuceanu Stefania‐Felicia , Saramet Ioana , Draghici Constantin 
Published: September 2010

AbstractAll newly synthesized compounds of type (I)—(III) are screened for their antibacterial activity but are less active than the reference drugs tetracycline and ampicilline.
ChemInform Abstract: Synthesis, Antiinflammatory and Ulcerogenicity Studies of Some Substituted Pyrimido[1,6‐a]azepine Derivatives.
Authors: El‐Sayed Nehad A. , Awadallah Fadi M. , Ibrahim Nashwa A. , El‐Saadi Mohammed T. 
Published: September 2010

AbstractThe amino group in key compound (Ia) is functionalized using common substitution or condensation reactions.
ChemInform Abstract: Synthesis and Pharmacological Evaluation of Novel Substituted 9‐Deazaxanthines as A2B Receptor Antagonists.
Authors: Nieto Maria Isabel , Balo Maria Carmen , Brea Jose , Caamano Olga , Fernandez Franco , Garcia‐Mera Xerardo , Lopez Carmen , Loza Maria Isabel , Rodriguez‐Borges Jose Enrique , Vidal Bernat 
Published: September 2010

AbstractA series of novel 9‐deazaxanthine derivatives with various substituents at the heterocyclic system is synthesized and evaluated for binding affinities for the four human recombinant adenosine receptors, A1—A3 subtypes.
Atrioventricular Dissociation due to Pheochromocytoma in a Young Adult
Authors: Haine Steven E. , Miljoen Hielko p. , Blankoff Ivan , Vrints Chris J. 
Published: September 2010

AbstractAtrioventriculardissociation can be amanifestationof an underlying noncardiacdisease.We present a patient who underwent pacemaker implantation because of intermittent atrioventricular dissociation and medically untreatable supraventricular arrhythmias, which could not be induced by electrophysiological testing. The arrhythmias proved to be due to a pheochromocytoma. After left adrenalectomy, both the supraventricular arrhythmias and the atrioventricular dissociation disappeared. Adequate recognition and treatment of pheochromocytoma can reverse atrioventricular dissociation and may avoid unnecessary procedures such as electrophysiological testing and pacemaker implantation.
Modification of MR molecular imaging probes with cysteine‐terminated peptides and their potential forin vivotumour detection
Authors: Xu Fenghua , Lei Du , Du Xiaoxia , Zhang Chunfu , Xie Xuan , Yin Duanzhi 
Published: September 2010

AbstractOne of the challenges facing superparamagnetic iron oxide (SPIO) nanoparticles is to improve their biological compatibility. While highly uniform SPIOs can be manufactured, the surfaces are hydrophobic as a result of the surfactants used in their fabrication. In this study, we developed a general strategy to fabricate an MR molecular imaging probe in one step by replacing hydrophobic surfactants with small peptides terminated with cysteine. The hydrophobic SPIO surface was transformed into a hydrophilic one by exchanging surface oleic acids with the peptides RGD–Cys or RGD–PEG–Cys. After the RGD–Cys and RGD–PEG–Cys peptide exchange, both RGD–Cys–SPIO and RGD–PEG–Cys–SPIO specifically targetedαvβ3‐expressing cells (A549)in vitro, with RGD–Cys–SPIO achieving this more efficiently. Furthermore, MR imaging of A549 tumors receiving RGD–Cys–SPIO or RGD–PEG–Cys–SPIO demonstrated that both the targeted particles could reach and label theαvβ3‐expressing tumor, much more efficiently than the non‐targeted particles (Cys–SPIO). Histology showed that the probes not only target the tumor neovasculature but also extravasate from vessels and address the tumor cells. Our study shows that directly replacing oleic acid with cysteine or cysteine‐terminated small peptides is a general strategy to transforming the hydrophobic surface of SPIO into a hydrophilic one, as well as providing targeting ligands. Such SPIOs are of interest as MR molecular imaging probes to detect for cancerin vivo. Copyright © 2010 John Wiley & Sons, Ltd.
Many Faces of Entropy or Bayesian Statistical Mechanics
Authors: Starikov Evgeni B. 
Published: September 2010

AbstractSome 80–90 years ago, George A. Linhart, unlike A. Einstein, P. Debye, M. Planck and W. Nernst, managed to derive a very simple, but ultimately general mathematical formula for heat capacity versus temperature from fundamental thermodynamic principles, using what we would nowadays dub a “Bayesian approach to probability”. Moreover, he successfully applied his result to fit the experimental data for diverse substances in their solid state over a rather broad temperature range. Nevertheless, Linhart’s work was undeservedly forgotten, although it represents a valid and fresh standpoint on thermodynamics and statistical physics, which may have a significant implication for academic and applied science.
Ultrastructural and molecular distinctions between the porcine inner cell mass and epiblast reveal unique pluripotent cell states
Authors: Hall Vanessa J. , Jacobsen Janus V. , Rasmussen Mikkel A. , Hyttel Poul 
Published: September 2010

AbstractCharacterization of the pluripotent cell populations within the porcine embryo is essential for understanding pluripotency and self‐renewal regulation in the inner cell mass (ICM) and epiblast. In this study, we perform detailed ultrastructural and molecular characterization of the developing pluripotent cell population as it develops from the ICM to the late epiblast. The ultrastructural observations revealed that the outer cells of the ICM have a high nuclear:cytoplasmic ratio but are transcriptionally inactive and contain mitochondria with few cristae. In contrast, the epiblast cells have a reduced nuclear:cytoplasmic ratio, are more transcriptionally active, and contain abundant cellular organelles. This study also revealed cavitation and potential unfolding of the epiblast. As the ICM forms the epiblast, SSEA1 is lost and VIMENTIN is lost and re‐expressed. The D6 blastocyst expressed high levels of STELLA, TERF1, and GDF3, and the epiblast expressed epithelial markers, MUC1 and E‐CADHERIN, and the pluripotency markers, DNMT3B and CRIPTO. Developmental Dynamics 239:2911–2920, 2010. © 2010 Wiley‐Liss, Inc.
Staging of regeneration process of an arm of the feather star Oxycomanthus japonicus focusing on the oral‐aboral boundary
Authors: Shibata Tomoko F. , Oji Tatsuo , Akasaka Koji , Agata Kiyokazu 
Published: September 2010

AbstractCrinoids have strong regenerative capability and rapidly restore their lost body parts such as arms. We observed the regeneration process of arms of the feather star (stalkless crinoid), Oxycomanthus japonicus, and divided the process into 10 stages. We clarify the position at which the oral and aboral epidermis adhere in wound closure and track the oral‐aboral boundary in the regenerate during the entire process of regeneration. We suggest that the concepts of distalization and intercalation, which are proposed to understand animal regeneration integrally, are also applicable to arm regeneration of the feather star. In addition, we clarify that pinnules, appendages extending from the sides of an arm, start to grow in the oral region of the regenerating arm even though a complete pinnule has an oral‐aboral axis. The mode of morphogenesis of pinnules in arm regeneration suggests that the oral region functions as the primary patterning tissue for pinnules. Developmental Dynamics 239:2947–2961, 2010. © 2010 Wiley‐Liss, Inc.
Construction of a Series of 1D and 2D Inorganic–Organic Hybrid Coordination Polymers Based on 1,1′‐Bis(propionic acid)‐2,2′‐biimidazole
Authors: Sang Rui‐Li , Xu Li 
Published: September 2010

AbstractThe substitution reactions of cadmium or zinc nitrate and the new multifunctional ligand Pra2biim2– [Pra2biim = 1,1′‐bis(propionic acid)‐2,2′‐biimidazole] produce a series ofcoordination polymers with d10 metal centers, namely, 1D [Cd(HPra2biim)(H2O)Cl]n·nH2O (1), 1D [Cd2(Pra2biim)(H2O)4(NO3)2]n (2), and 2D [Zn(HPra2biim)Cl]n (3) in acidic aqueous solutions. The presence of a strong inorganic acid, such as HCl, lead to the protonation of Pra2biim2– as observed in polymers 1 and 3. Compounds 1 and 3 contain the doubly N,N′‐biim‐bridged [M2(μ2‐N,N′‐biim)2] and compound 2 the singly bridged [M2(μ2‐N,N′‐biim)] as secondary building blocks that are interconnected by the propionate arms into 1D chains in 1 and 2, and into a 2D layer in 3. These d10 metal polymers exhibit luminescent emissions that are sensitive to the coordination geometry of the metal centers.
Linking human capital to competitive advantages: Flexibility in a manufacturing firm's supply chain
Authors: Jin Yan , Hopkins Margaret M. , Wittmer Jenell L. S. 
Published: September 2010

AbstractFlexibility in a manufacturing firm is a strategic choice that advances the firm's superior performance. This is especially true in the emerging supply chain, which makes the firm's environment particularly turbulent. This paper examines the critical relationships between a manufacturing firm's human capital, the firm's flexibility, suppliers' flexibility, and the firm's competitive advantages. Based on questionnaire responses from 201 senior supply chain management professionals in several manufacturing industries, this study establishes direct links between a manufacturing firm's human capital and the firm's superior flexibility, and between a manufacturing firm's flexibility and its competitive advantages. In addition, this research finds that the firm's flexibility mediates the relationship between the firm's human capital and its competitive advantages, as does the connection between the suppliers' flexibility and the firm's competitive advantages. © 2010 Wiley Periodicals, Inc.
Guest Editors' Note: Don't miss the boat: Research on HRM and supply chains
Authors: Fisher Sandra L. , Graham Mary E. , Vachon Stephan , Vereecke Ann 
Published: September 2010

AbstractThis paper provides an introduction to the special issue on human resource management (HRM) in supply chains. To this point, HRM researchers have paid little attention to the field of supply chain management (SCM) and how HRM practices may help firms manage their supply chains more effectively. We provide an overview of supply chain management for readers new to this field. We conceptualize three potential applications of HRM in supply chains, and then use our framework to introduce and link the papers that comprise the special issue. © 2010 Wiley Periodicals, Inc.
Evolving HR practices in a strategic intra‐firm supply chain
Authors: Koulikoff‐Souviron Marie , Harrison Alan 
Published: September 2010

AbstractWhile there are several studies on human resource management (HRM) at the inter‐firm dyadic relationship level, the HR aspects of intra‐firm strategic supply relationships have been largely ignored. Yet interdependence requires coordination among functions, sites, and stages of the internal supply chain (SC). Drawing on a case study of a large European pharmaceutical company, which we call Tyrenco, we explore how HR practices evolve within the strategic intra‐firm supply relationship. Our findings illustrate the disruptive effects of HR practices when they are focused on site‐based objectives and the improved coordination that results from redesigning HR processes to achieve internal operational integration. We highlight the tension between site‐based, financial controls and an emergent SC logic. Drawing on recent interest in cooperative approaches to HR practices, this study seeks to operationalize the need to align HR practices with end‐to‐end objectives at different stages of the intra‐firm supply chain. Our findings have practical implications for designing HR practices within multinational corporations (MNCs) that are characterized by complex and fragmented internal environments. © 2010 Wiley Periodicals, Inc.
CEOs with a functional background in operations: Reviewing their performance and prevalence in the top post
Authors: Koyuncu Burak , Firfiray Shainaz , Claes Björn , Hamori Monika 
Published: September 2010

AbstractWith this study, we update research by Ocasio and Kim (1999) by testing whether the trends that favored the prevalence of CEOs with an operations background in the 1980s and early 1990s continued between 1992 and 2005. Given that supply chain management became a top business priority during this period, we expect a greater prevalence of CEOs with an operations background. This is because, traditionally, executives belonging to the operations function have assumed responsibility for supply chain management issues. Our results, based on a sample of 437 CEOs who lead large‐sized U.S. firms in eight industries, provide partial support for the hypothesis that CEOs with a functional background in operations attain higher post‐succession performance than CEOs with other functional backgrounds. In addition, we find that the likelihood that newly appointed CEOs have a background in operations is greater in succession events that have taken place more recently and in situations that occurred in the face of poor firm financial performance. © 2010 Wiley Periodicals, Inc.
Bedtime problems and night wakings: treatment of behavioral insomnia of childhood
Authors: Moore Melisa 
Published: September 2010

AbstractBedtime problems and frequent night wakings are common sleep problems in infants and toddlers, affecting 20 to 30% of young children. Such problems, categorized as behavioral insomnia of childhood (BIC), lead to insufficient sleep, which contributes to multiple domains of child dysfunction. Behavioral treatments of BIC, such as extinction and positive routines are introduced, and supporting evidence is reviewed. Critical factors in developing a successful treatment plan include conducting a detailed assessment, collaboratively developing a plan that starts where the family is, and providing support between sessions. A case of a 3‐year‐old girl with BIC illustrates how treatment helped her to develop healthy sleep habits and taught her to sleep independently via graduated and standard extinction. © 2010 Wiley Periodicals, Inc. J Clin Psychol: In Session 66:1–10, 2010.
Cognitive–behavioral therapy and hypnotic relaxation to treat sleep problems in an adolescent with diabetes
Authors: Perfect Michelle M. , Elkins Gary R. 
Published: September 2010

AbstractInadequate sleep among adolescents frequently contributes to obesity and reduced academic performance, along with symptoms of anxiety, depression, fatigue, and attention deficits. The etiological bases of sleep quality has been associated with both stress and sleep habits. These problems tend to be especially important for adolescents with diabetes as the effects of poor sleep complicate health outcomes. This case example concerns a 14‐year‐old adolescent girl with a history of type I diabetes and stress‐related sleep difficulties. Treatment included cognitive–behavioral methods and hypnotic relaxation therapy. Results of this case example and other controlled research suggest that hypnotic relaxation therapy is well accepted, results in good compliance, and serves as a useful adjunctive to cognitive–behavioral intervention for sleep problems. © 2010 Wiley Periodicals, Inc. J Clin Psychol: In Session 66:1–11, 2010.
The economic footing of the global poor, 1980–2005: The roles of economic growth, openness and political institutions
Authors: Wagle Udaya R. 
Published: September 2010

AbstractThe period between 1980 and 2005 registered declining poverty, especially in its extreme form, and increasing economic inequality with implications for the economic footing of the global poor‐ and low‐income groups. Disentangling the roles of economic growth, openness and political institutions in determining poverty and inequality using cross‐national data faces enormous methodological challenges. Nevertheless, panel data regressions estimated here suggest that the poor‐ and low‐income groups do not benefit much from economic openness and political democracy. While economic growth and government expenditures do not significantly affect poverty, they prove somewhat effective at containing inequality. Copyright © 2010 John Wiley & Sons, Ltd.
Metal neck and liner impingement in ceramic bearing total hip arthroplasty
Authors: Lee Young‐Kyun , Yoo Jeong Joon , Koo Kyung‐Hoi , Yoon Kang Sup , Kim Hee Joong 
Published: September 2010

AbstractAlthough impingement between the neck of the metallic stem and the ceramic liner has been suspected to be the cause of ceramic liner failure in ceramic‐on‐ceramic total hip arthroplasty (THA), no report has directly demonstrated microscopic damage on ceramic liner. We performed 18 reoperations on 18 patients who had undergone third generation ceramic‐on‐ceramic THA. Considering impingement, 16 patients, who were reoperated more than 1 year after previous ceramic bearing THA, were evaluated. Retrieved alumina liners, showing evidence of impingement, were examined by means of visual inspection and scanning electron microscopy (SEM). Four of the 16 hips showed neck notching and black stained liners, evidence of metallic neck to ceramic impingement. Impinged alumina bearings had been implanted for an average of 62.5 months (range: 35–99 months) before reoperation. SEM of the black stained area demonstrated disruptive wear and loss of surface integrity. Furthermore, one liner had multiple microcracks, and its cross‐sectional SEM analysis revealed one microcrack propagating into the deep portion of the ceramic liner. Our observations suggest that metal neck‐to‐ceramic impingement in ceramic‐on‐ceramic THA can cause microcrack formation in ceramic liner. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 29:218–222, 2011
Wavelet Approximation of GRID Fields: Application to Quantitative Structure‐Activity Relationships
Authors: Martin Richard L. , Gardiner Eleanor , Gillet Valerie J. , Muñoz‐Muriedas Jordi , Senger Stefan 
Published: September 2010

AbstractMolecular interaction fields such as those computed by the GRID program are widely used in applications such as virtual screening, molecular docking and 3D‐QSAR modelling. They characterise molecules according to their favourable interaction sites and therefore enable predictions to be made on how molecules might interact. The fields are, however, comprised of a very large number of data points which presents difficulties for many applications. For example, there are likely to be high degrees of correlation between the variables which can lead to misleading results in 3D‐QSAR. We describe the use of wavelet methods for approximating such data into a much smaller number of variables. We present a number of validation experiments, including use of the approximated GRIDs in 3D‐QSAR, and demonstrate that wavelet approximation at high levels of data compression preserves the information content in GRID fields while significantly reducing computational requirements.
Rotational failure mechanisms for the face stability analysis of tunnels driven by a pressurized shield
Authors: Mollon Guilhem , Dias Daniel , Soubra Abdul‐Hamid 
Published: September 2010

AbstractThe aim of this paper is to determine the collapse and blow‐out face pressures of a circular tunnel driven by a pressurized shield. The analysis is performed in the framework of the kinematical approach of the limit analysis theory. Two rotational failure mechanisms are proposed for the active and passive cases. These mechanisms have two significant advantages with respect to the available ones: (i) they take into account the entire circular tunnel face instead of an inscribed ellipse to this circular area, and (ii) they are more consistent with the rotational rigid‐block movement observed in the experimental tests. For both the active and passive cases, the three‐dimensional failure surface was generated ‘point by point’ instead of simple use of the existing standard geometric shapes such as cones or cylinders. This was achieved by employing a spatial discretization technique. The numerical results have shown that the present rotational mechanisms provide, in the case of frictional soils (with or without cohesion), a significant improvement with respect to the translational mechanisms. Finally, an extension of the proposed collapse mechanism to include a tension cut‐off in the classical Mohr–Coulomb failure criterion is presented and discussed. Copyright © 2010 John Wiley & Sons, Ltd.
Analysis of shaft resistance of jacked piles in sands
Authors: Basu Prasenjit , Loukidis Dimitrios , Prezzi Monica , Salgado Rodrigo 
Published: September 2010

AbstractIn recent years, pile jacking has become a viable alternative installation method for displacement piles. Pile jacking produces minimal noise, vibration and air pollution during installation. In addition, it is possible, at the end of jacking, to have a good estimate of the ultimate static capacity of the pile. In this paper, the shaft resistance of piles jacked into sand is studied using one‐dimensional finite element analysis. The finite element simulations, using a two‐surface plasticity model, demonstrate the effects of relative density and confinement on the unit shaft resistance of piles jacked in sand. The impact of the number of jacking strokes on the unit shaft capacity is also assessed. Based on the numerical results, we developed equations for shaft resistance quantifying the effects of relative density, initial confinement and number of jacking strokes. Predictions using these equations are compared with data obtained from centrifuge tests and field tests. Copyright © 2010 John Wiley & Sons, Ltd.