bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association betweenFaecalibacterium prausnitziiand dietary fibre in colonic fermentation in healthy human subjects
Authors: Benus Robin F. J. , van der Werf Tjip S. , Welling Gjalt W. , Judd Patricia A. , Taylor Moira A. , Harmsen Hermie J. M. , Whelan Kevin 
Published: March 2010

The intestinal microbiota are a complex ecosystem influencing the immunoregulation of the human host, providing protection from colonising pathogens and producing SCFA as the main energy source of colonocytes. Our objective was to investigate the effect of dietary fibre exclusion and supplementation on the intestinal microbiota and SCFA concentrations. Faecal samples were obtained from healthy volunteers before and after two 14 d periods of consuming formulated diets devoid or supplemented with fibre (14 g/l). The faecal microbiota were analysed using fluorescentin situhybridisation and SCFA were measured using GLC. There were large and statistically significant reductions in the numbers of theFaecalibacterium prausnitzii(P ≤ 0·01) andRoseburiaspp. (P ≤ 0·01) groups during both the fibre-free and fibre-supplemented diets. Significant and strong positive correlations between the proportion ofF. prausnitziiand the proportion of butyrate during both baseline normal diets were found (pre-fibre freer0·881,P = 0·001; pre-fibre supplementedr0·844,P = 0·002). A significant correlation was also found between the proportional reduction inF. prausnitziiand the proportional reduction in faecal butyrate during both the fibre-free (r0·806;P = 0·005) and the fibre-supplemented diet (r0·749;P = 0·013). These findings may contribute to the understanding of the association between fibre, microbiota and fermentation in health, during enteral nutrition and in disease states such as Crohn's disease.
A NOTE ON HIGHER TWISTS OF ELLIPTIC CURVES
Authors: ULAS MACIEJ 
Published: March 2010

AbstractWe show that for any pair of elliptic curves E1, E2 over ℚ with j-invariant equal to 0, we can find a polynomial D ∈ ℤ[u, v] such that the cubic twists of the curves E1, E2 by D(u, v) have positive rank over ℚ(u, v). We also prove that for any quadruple of pairwise distinct elliptic curves Ei, i = 1, 2, 3, 4, with j-invariant j = 0, there exists a polynomial D ∈ ℤ[u] such that the sextic twists of Ei, i = 1, 2, 3, 4, by D(u) have positive rank. A similar result is proved for quadruplets of elliptic curves with j-invariant j = 1, 728.
ON MODpREPRESENTATIONS WHICH ARE DEFINED OVERp: II
Authors: KILFORD L. J. P. , WIESE GABOR 
Published: March 2010

AbstractThe behaviour of Hecke polynomials modulophas been the subject of some studies. In this paper we show that ifpis a prime, the set of integersNsuch that the Hecke polynomialsTN,χℓ,kfor all primes ℓ, all weightsk≥ 2 and all characters χ taking values in {±1} splits completely modulophas density 0, unconditionally forp= 2 and under the Cohen–Lenstra heuristics forp≥ 3. The method of proof is based on the construction of suitable dihedral modular forms.
ON THE CONNECTEDNESS OF THE BRANCH LOCUS OF THE MODULI SPACE OF RIEMANN SURFACES OF GENUS 4
Authors: COSTA ANTONIO F. , IZQUIERDO MILAGROS 
Published: March 2010

AbstractUsing uniformization of Riemann surfaces by Fuchsian groups and the equisymmetric stratification of the branch locus of the moduli space of surfaces of genus 4, we prove its connectedness. As a consequence, one can deform a surface of genus 4 with automorphisms, i.e. symmetric, to any other symmetric genus 4 surface through a path consisting entirely of symmetric surfaces.
A latent profile analysis of the typology of bulimic symptoms in an indigenous Pacific population: evidence of cross-cultural variation in phenomenology
Authors: Thomas J. J. , Crosby R. D. , Wonderlich S. A. , Striegel-Moore R. H. , Becker A. E. 
Published: March 2010

BackgroundPrevious efforts to derive empirically based eating disorder (ED) typologies through latent structure modeling have been limited by the ethnic and cultural homogeneity of their study populations and their reliance on DSM-IV ED signs and symptoms as indicator variables.MethodEthnic Fijian schoolgirls (n=523) responded to a self-report battery assessing ED symptoms, herbal purgative use, co-morbid psychopathology, clinical impairment, cultural orientation, and peer influences. Participants who endorsed self-induced vomiting or herbal purgative use in the past 28 days (n=222) were included in a latent profile analysis (LPA) to identify unique subgroups of bulimic symptomatology.ResultsLPA identified a bulimia nervosa (BN)-like class (n=86) characterized by high rates of binge eating and self-induced vomiting, and a herbal purgative class (n=136) characterized primarily by the use of indigenous Fijian herbal purgatives. Both ED classes endorsed greater eating pathology and general psychopathology than non-purging participants, and the herbal purgative class endorsed greater clinical impairment than either the BN-like or non-purging participants. Cultural orientation did not differ between the two ED classes.ConclusionsIncluding study populations typically under-represented in mental health research and broadening the scope of relevant signs and symptoms in latent structure models may increase the generalizability of ED nosological schemes to encompass greater cultural diversity.
Regaining mental capacity for treatment decisions following psychiatric admission: a clinico-ethical study
Authors: Owen G. S. , Ster I. Chis. , David A. S. , Szmukler G. , Hayward P. , Richardson G. , Hotopf M. 
Published: March 2010

BackgroundMental capacity is an emerging ethical legal concept in psychiatric settings but its relation to clinical parameters remains uncertain. We sought to investigate the associations of regaining capacity to make treatment decisions following approximately 1 month of in-patient psychiatric treatment.MethodWe followed up 115 consecutive patients admitted to a psychiatric hospital who were judged to lack capacity to make treatment decisions at the point of hospitalization. We were primarily interested in whether the diagnosis of schizophrenia and schizoaffective disorder associated with reduced chances of regaining capacity compared with other diagnoses and whether affective symptoms on admission associated with increased chances of regaining capacity. In addition, we examined how change in insight was associated with regaining capacity in schizophrenia, bipolar affective disorder (BPAD)-mania, and depression.ResultsWe found evidence that the category of ‘schizophrenia or schizoaffective disorder’ associated with not regaining capacity at 1 month compared with BPAD-mania [odds ratio (OR) 3.62, 95% confidence intervals (CI) 1.13–11.6] and depression (OR 5.35, 95% CI 1.47–9.55) and that affective symptoms on admission associated with regaining capacity (OR 1.23, 95% CI 1.02–1.48). In addition, using an interaction model, we found some evidence that gain in insight may not be a good indicator of regaining capacity in patients with depression compared with patients with schizophrenia and BPAD-mania.ConclusionsWe suggest that clinico-ethical studies using mental capacity provide a way of assessing the validity of nosological and other clinical concepts in psychiatry.
Accounting for the association between childhood maltreatment and alcohol-use disorders in males: a twin study
Authors: Young-Wolff K. C. , Kendler K. S. , Ericson M. L. , Prescott C. A. 
Published: March 2010

BackgroundAn association between childhood maltreatment and subsequent alcohol abuse and/or dependence (AAD) has been found in multiple studies of females. Less is known about the association between childhood maltreatment and AAD among males, and the mechanisms that underlie this association in either gender. One explanation is that childhood maltreatment increases risk for AAD. An alternative explanation is that the same genetic or environmental factors that increase a child's risk for being maltreated also contribute to risk for AAD in adulthood.MethodLifetime diagnosis of AAD was assessed using structured clinical interviews in a sample of 3527 male participants aged 19–56 years from the Virginia Adult Twin Study of Psychiatric and Substance Use Disorders. The sources of childhood maltreatment–AAD association were estimated using both a matched case–control analysis of twin pairs discordant for childhood maltreatment and bivariate twin modeling.ResultsApproximately 9% of participants reported childhood maltreatment, defined as serious neglect, molestation, or physical abuse occurring before the age of 15 years. Those who experienced childhood maltreatment were 1.74 times as likely to meet AAD criteria compared with males who did not experience childhood maltreatment. The childhood maltreatment–AAD association largely reflected environmental factors in common to members of twin pairs. Additional exploratory analyses provided evidence that AAD risk associated with childhood maltreatment was significantly attenuated after adjusting for measured family-level risk factors.ConclusionsMales who experienced childhood maltreatment had an increased risk for AAD. Our results suggest that the childhood maltreatment–AAD association is attributable to broader environmental adversity shared between twins.
Even Conservative Unions Have Revolutionary Effects: Frank Tannenbaum on the Labor Movement
Authors: Merrill Michael 
Published: March 2010

AbstractFrank Tannenbaum is best known for his studies of Mexican agrarian reform and for his contributions to the comparative history of slavery and slave societies. But as a young man he had made a name for himself as a notorious labor agitator, and he went on to publish two books on the US labor movement, which are worthy of reconsideration as important interpretations of independent trade unionism and political reform. The first volume appeared in 1921 and offered an original perspective on the popular syndicalism that formed such a large, positive element of the philosophy of the International Workers of the World (IWW), to the extent it had one, at the center of which lay the struggle for social recognition on the part of immigrant and (supposedly) unskilled workers. The second appeared thirty years later and provided a thoughtful defense of the private, employment-based welfare and industrial relations system that the New Deal established in the United States. Together the books offer a provocative account of the social and individual radicalism of US-style “pure and simple” trade unionism.
Changing concepts of endocardial fibroelastosis
Authors: Lurie Paul R. 
Published: March 2010

AbstractEndocardial fibroelastosis is not a disease but a reaction of the endocardium. I review the history of the term with emphasis on the gradual understanding of the many causes of this reaction. I include a comprehensive list of diseases or other cardiac stresses that authors have reported in association, and I try to explain the mechanism of the reaction. Although endocardial fibroelastosis is rare today, I issue a warning of a possible epidemic recrudescence of some of the associated diseases. My hope is for nosologic purity, therefore that outworn but surviving concepts will be firmly rejected.
Lithology, mineral assemblages and microbial fingerprints of the evaporite-carbonate sediments of the coastal sabkha of Abu Dhabi and their extraterrestrial implications
Authors: Sadooni Fadhil N. , Howari Fares , Edwards Howell G.M. , El-Saiy Ayman 
Published: March 2010

AbstractDeep-core and surface samples collected from the coastal sabkha of Abu Dhabi were subjected to a multi-proxy study, including petrographic, geochemical and spectroscopic analyses. The sediments studied are composed of biochemical carbonate-evaporite mineral suites, such as calcite, dolomite, aragonite and gypsum, as well as clastic minerals, such as quartz, feldspar and serpentine. These sediments were also strongly influenced by microbial activities as reflected by the presence of cyanobacterial mats, boring, gas bubble structures, pustular and other macro and micro textures. A combination of marine, fluvial, aeolian, and groundwater processes shaped the geomorphology of the area and led to the formation of such mineral suites, as well as their microbial contents. Data collected from Mars indicate that its surface regolith contains sandstone composed of siliciclastic basaltic debris, as well as carbonate (e.g. magnesite) and evaporite (e.g. jarosite and relics of gypsum) mineral assemblages. Additional data suggest the presence of geomorphic features, characteristic of an arid climate, such as sand dunes and desert varnish. The hydrological model for the Late Noachian-Hesperian period of the plant proposed the existence of a surficial layer containing endolithic and stromatolitic cyanobacterial lamina. The combination of the coastal sabkha of Abu Dhabi with its carbonate-evaporite mineral suites, the neighbouring sand dune fields of the Empty Quarter Desert and the basaltic sediments resulted from weathering the ophiolitic Northern Oman Mountains to form a candidate terrestrial geologic province that may explain the mineral association of Mars and its potential biosignatures. The lithological features and the mineral association of the sabkha can be recognized by the present day detection equipment used on Mars, and even if their biosignatures are degraded, their existence may be inferred from these features.
Realizing the Potential of Satellite Gravimetry for Hydrology: Second GRACE Hydrology Workshop; Austin, Texas, 4 November 2009
Authors: Rodell Matthew , Famiglietti James S. , Scanlon Bridget R. 
Published: March 2010

Hydrologists and geodesists met in November to share new results and discuss ways to facilitate the use of Gravity Recovery and Climate Experiment (GRACE) products for hydrological research and applications. More than 70 scientists from eight countries participated. Recommendations from the workshop were presented subsequently at the GRACE science team meeting.The NASA/German Aerospace Center's GRACE mission, launched in 2002, provides a unique perspective on the water cycle. GRACE measures tiny variations in Earth's gravity field, from which are inferred changes in total column water: the sum of groundwater, soil moisture, surface water, snow, ice, and biomass. Workshop presentations included river basin—scale budget studies; groundwater, snow, river runoff, and ice sheet melt assessments; GRACE data assimilation; drought monitoring; and several papers devoted to data processing issues.
Nitric oxide triggers mammary gland involution after weaning: remodelling is delayed but not impaired in mice lacking inducible nitric oxide synthase
Authors: Zaragozá Rosa , Bosch Ana , García Concha , Sandoval Juan , Serna Eva , Torres Luís , García-Trevijano Elena R. , Viña Juan R. 
Published: March 2010

During mammary gland involution, different signals are required for apoptosis and tissue remodelling. To explore the role of NO in the involution of mammary tissue after lactation, NOS2 (inducible nitric oxide synthase)-KO (knockout) mice were used. No apparent differences were observed between NOS2-KO and WT (wild-type) animals during pregnancy and lactation. However, upon cessation of lactation, a notable delay in involution was observed, compared with WT mice. NOS2-KO mice showed increased phosphorylation of STAT (signal transducer and activator of transcription) 5 during weaning, concomitant with increased β-casein mRNA levels when compared with weaned WT glands, both hallmarks of the lactating period. In contrast, activation of STAT3, although maximal at 24 h after weaning, was significantly reduced in NOS2-KO mice. STAT3 and NF-κB (nuclear factor κB) signalling pathways are known to be crucial in the regulation of cell death and tissue remodelling during involution. Indeed, activation of both STAT3 and NF-κB was observed in WT mice during weaning, concomitant with an increased apoptotic rate. During the same period, less apoptosis, in terms of caspase 3 activity, was found in NOS2-KO mice and NF-κB activity was significantly reduced when compared with WT mice. Furthermore, the activation of the NF-κB signalling pathway is delayed in NOS2-KO mice when compared with WT mice. These results emphasize the role of NO in the fine regulation of the weaning process, since, in the absence of NOS2, the switching on of the cascades that trigger involution is hindered for a time, retarding apoptosis of the epithelial cells and extracellular matrix remodelling.
Olfactory response termination involves Ca2+-ATPase in vertebrate olfactory receptor neuron cilia
Authors: Antolin Salome , Reisert Johannes , Matthews Hugh R. 
Published: March 2010

In vertebrate olfactory receptor neurons (ORNs), odorant-induced activation of the transduction cascade culminates in production of cyclic AMP, which opens cyclic nucleotide–gated channels in the ciliary membrane enabling Ca2+ influx. The ensuing elevation of the intraciliary Ca2+ concentration opens Ca2+-activated Cl− channels, which mediate an excitatory Cl− efflux from the cilia. In order for the response to terminate, the Cl− channel must close, which requires that the intraciliary Ca2+ concentration return to basal levels. Hitherto, the extrusion of Ca2+ from the cilia has been thought to depend principally on a Na+–Ca2+ exchanger.
In this study, we show using simultaneous suction pipette recording and Ca2+-sensitive dye fluorescence measurements that in fire salamander ORNs, withdrawal of external Na+ from the solution bathing the cilia, which incapacitates Na+–Ca2+exchange, has only a modest effect on the recovery of the electrical response and the accompanying decay of intraciliary Ca2+ concentration. In contrast, exposure of the cilia to vanadate or carboxyeosin, a manipulation designed to block Ca2+-ATPase, has a substantial effect on response recovery kinetics. Therefore, we conclude that Ca2+-ATPase contributes to Ca2+ extrusion in ORNs, and that Na+–Ca2+exchange makes only a modest contribution to Ca2+ homeostasis in this species.
Catheter-Related Polymicrobial Bloodstream Infections among Pediatric Bone Marrow Transplant Outpatients—Atlanta, Georgia, 2007
Authors: Wiersma Petra , Schillie Sarah , Keyserling Harry , Watson J. Renee , De Anindya , Banerjee Shailendra N. , Drenzek Cherie L. , Arnold Kathryn E. , Shivers Christina , Kendrick Lea , Ryan Lydia Gonzalez , Jensen Bette , Noble-Wang Judith , Srinivasan Arjun 
Published: March 2010

Objective.To identify risk factors for polymicrobial bloodstream infections (BSIs) in pediatric bone marrow transplant (BMT) outpatients attending a newly constructed clinic affiliated with a children's hospital.Methods.All 30 outpatients treated at a new BMT clinic during September 10-21, 2007, were enrolled in a cohort study. The investigation included interviews, medical records review, observations, and bacterial culture and molecular typing of patient and environmental isolates. Data were analyzed using exact conditional logistic regression.Results.Thirteen patients experienced BSIs caused by 16 different, predominantly gram-negative organisms. Presence of a tunneled catheter (odds ratio [OR], 19.9 [95% confidence interval {CI}, 2.4-∞), catheter access (OR, 13.7 [95% CI, 1.8-∞]), and flushing of a catheter with predrawn saline (OR, 12.9 [95% CI, 1.0-766.0]) were independently associated with BSI. The odds of experiencing a BSI increased by a factor of 16.8 with each additional injection of predrawn saline (95% CI, 1.8-827.0). Although no environmental source of pathogens was identified, interviews revealed breaches in recommended infection prevention practice and medication handling. Saline flush solutions were predrawn, and multiple doses were obtained from single-dose preservative-free vials to avoid delays in patient care.Conclusion.We speculate that infection prevention challenges in the new clinic, combined with successive needle punctures of vials, facilitated extrinsic contamination and transmission of healthcare-associated pathogens. We recommend that preservative-free single-use vials not be punctured more than once. Use of single-use prefilled saline syringes might prevent multiuse of single-use saline vials. Storage of saline outside a medication supply system might be advisable. Before opening new clinic facilities, hospitals should consider conducting a mock patient flow exercise to identify infection control challenges.
Trial of Universal Gloving with Emollient-Impregnated Gloves to Promote Skin Health and Prevent the Transmission of Multidrug-Resistant Organisms in a Surgical Intensive Care Unit
Authors: Bearman Gonzalo , Rosato Adriana E. , Duane Therese M. , Elam Kara , Sanogo Kakotan , Haner Cheryl , Kazlova Valentina , Edmond Michael B. 
Published: March 2010

Objective.To compare the efficacy of universal gloving with emollient-impregnated gloves with standard contact precautions for the control of multidrug-resistant organisms (MDROs) and to measure the effect on healthcare workers' (HCWs') hand skin health.Design.Prospective before-after trial.Setting.An 18-bed surgical intensive care unit.Methods.During phase 1 (September 2007 through March 2008) standard contact precautions were used. During phase 2 (March 2008 through September 2008) universal gloving with emollient-impregnated gloves was used, and no contact precautions. Patients were screened for vancomycin-resistantEnterococcus(VRE) and methicillin-resistantStaphylococcus aureus(MRSA). HCW hand hygiene compliance and hand skin health and microbial contamination were assessed. The incidences of device-associated infection andClostridium difficileinfection (CDI) were determined.Results.The rate of compliance with contact precautions (phase 1) was 67%, and the rate of compliance with universal gloving (phase 2) was 78% (P= .01). Hand hygiene compliance was higher during phase 2 than during phase 1 (before patient care, 40% vs 35% of encounters;P= .001; after patient care, 63% vs 51% of encounters;P&lt; .001). No difference was observed in MDRO acquisition. During phases 1 and 2, incidences of device-related infections, in number of infections per 1,000 device-days, were, respectively, 3.7 and 2.6 for bloodstream infection (P= .10), 8.9 and 7.8 for urinary tract infection (P= .10), and 1.0 and 1.1 for ventilator-associated pneumonia (P= .09). The CDI incidence in phase 1 and in phase 2 was, respectively, 2.0 and 1.4 cases per 1,000 patient-days (P= .53). During phase 1, 29% of HCW hand cultures were MRSA positive, compared with 13% during phase 2 (P= .17); during phase 1, 2% of hand cultures were VRE positive, compared with 0 during phase 2 (P= .16). Hand skin health improved during phase 2.Conclusions.Compared with contact precautions, universal gloving with emollient-impregnated gloves was associated with improved hand hygiene compliance and skin health. No statistically significant change in the rates of device-associated infection, CDI, or patient MDRO acquisition was observed. Universal gloving may be an alternative to contact precautions.