bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single‐step mineralization of woodpile chitosan scaffolds with improved cell compatibility
Authors: Li Lihua , Li Bo , Zhao Mingyan , Ding Shan , Zhou Changren 
Published: June 2011

AbstractA facile and efficient single‐step mineralization approach was exploited for achieving nanoscopic hydroxyapatite (HAP) crystal layer in chitosan porous matrix, wherein a mixed water–ethanol solvent was used to control the growth of minerals. The crystallographic structure, morphology, and mechanical properties of the scaffold were analyzed with XRD, FTIR, environmental scanning electric microscopy (ESEM), TEM, and compression tests. The behaviors and responses of MC3T3‐E1 pre‐osteoblast cells on the scaffolds were studied as well. The results showed that the scaffolds kept woodpile structure with predefined and controlled hierarchical structure after mineralization. The inorganic phase in the mineralized chitosan scaffolds was determined as pure rod‐like HAP, which settled densely on the matrix. The compression strength and compressive modulus of the scaffolds increased dramatically to 0.54 ± 0.005 MPa and 5.47 ± 0.65 MPa, respectively. During a culture period of 2 and 3 weeks, cell proliferation and in‐growth were observed by phase contrast light microscopy and SEM. The alkaline phosphatase (ALP) activity increased after 1 week. Cell viability and cell proliferation index (PI) obtained higher values than that of the chitosan scaffolds. The novel single‐step mineralization approach and the porous hybrid scaffolds would be a promising method for designing hybrid bone graft. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.
Restoration of longitudinal growth by bioengineered cartilage pellet in physeal injury is not affected by low intensity pulsed ultrasound
Authors: Chow Simon Kwoon‐Ho , Lee Kwong‐Man , Qin Ling , Leung Kwok‐Sui , Cheung Wing‐Hoi 
Published: June 2011

AbstractPhyseal fracture is a common pediatric fracture that would result in premature physeal closure in long bones, and there is currently no gold standard for its management. In this study, we investigated the application of a Bioengineered Cartilage Pellet (BCP) in repairing a rabbit physeal fracture model, and the possible effects of Low Intensity Pulsed Ultrasound (LIPUS) treatment. Rabbits with physeal fracture created were assigned to the NC group (no BCP, no LIPUS), GC group (BCP, no LIPUS), and GT group (BCP and LIPUS). Femoral lengths and cartilage area were assessed at 4, 8, and 16 weeks post‐defect. After transplantation, the BCP showed continuous growth in the host and demonstrated resemblance to a natural growth plate. The GC group showed 34.1, 32.1, and 41.1% advantage in lengthening over the NC group and the GT group showed 51.1, 41.6, and 26.9% improved lengthening than the NC group, at 4 (p = 0.203), 8 (p = 0.543) and 16 weeks (p = 0.049), respectively. Cartilage area was shown to be significantly higher in GC and GT group compared to NC group (p < 0.05). No significant difference was found between GC and GT group. Femoral longitudinal growth was shown to be improved by the BCP, however no additional enhancement effect was shown to be provided by LIPUS. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.
Cavity‐backed slot array antenna in substrate‐integrated waveguide technology
Authors: Jiménez‐Fernández Manuel J. , Torres‐Sánchez Roberto , Otero Pablo 
Published: June 2011

AbstractA slot array placed on the face of a cavity realized in substrate‐integrated waveguide technology is presented. Guidelines to design similar antennas are provided. The design has been done with the help of commercial software. The result is a low‐cost, directive array antenna with a single feeding microstrip‐line. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26165
FET Frequency doubler with out‐of‐phase switchable output and application in balanced frequency doubler
Authors: Yang Ning , Caloz Christophe , Wu Ke 
Published: June 2011

AbstractA field effect transistor (FET) frequency doubler, with 180° out‐of‐phase alternate output by switching the bias status of FET at pinch‐off (Vgg ≈ Vt) or saturation (Vgg ≈ 0) is proposed.With such bias conditions, the former conducts in the positive half‐cycle of the input signal, while the latter conducts in the negative half‐cycle. Based on this concept, a new frequency doubler architecture is proposed. Without an input balun, it is more compact than conventional balanced frequency doubler. In addition, it provides an alternate doubler with differential output. To demonstrate this concept, a single‐ended 5–10 GHz doubler tested at the two bias conditions is designed and demonstrated experimentally to provide opposite‐phase outputs for the two cases. The output phase difference error is less than 4° and over 42‐dB fundamental frequency rejection is achieved. The conversion gain measured at 10 GHz is 2.5 dB for an input power of 5 dBm. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26172
A study of erbium–ytterbium‐codoped polymer waveguide amplifier
Authors: Zhang Dan , Zhang Daming , Liang Xu , Wang Fei , Guo Donghui 
Published: June 2011

AbstractIn this article, organic/inorganic hybrid matrix doped with Er3+,Yb3+ nanoparticles was synthesized and used as the core material to fabricate the waveguide amplifier. The absorption and luminescence spectra of the material were characterized. An X‐ray photoelectron spectroscopy analysis was performed to characterize the changes on the surface elemental composition of the material in the reactive ion etching processes. An embedded channel waveguides based on this material were demonstrated. Optical gains of 2.3 and 3.5 dB/cm at 1534 and 1550 nm wavelengths, respectively, were obtained in different dimensions of waveguides. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26193
Printed two monopole‐antenna system with a decoupling neutralization line for 2.4‐GHz MIMO applications
Authors: Su Saou‐Wen , Lee Cheng‐Tse 
Published: June 2011

AbstractA multiantenna system with two printed monopoles decoupled by using the neutralization‐line technique for 2.4‐GHz‐MIMO USB dongles is presented. The two monopoles are located on the two opposite corners of the PCB and spaced 10.5 mm apart by a small ground portion, which provides a layout area for antenna feeding network and optional I‐PEX connectors for the use of standalone antennas. It was found that by removing only 1‐mm‐long inwards from the edge and linking two monopoles therein by a thin printed line, the antenna port isolation can be effectively improved. This decoupling line occupies little board space such that there requires no conventional modification to the system ground plane for mitigating the mutual coupling. The proposed design is very suitable for the wireless module‐card solution in the form factor of a USB dongle. Details of the design prototype are discussed in the article. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26199
Novel triple‐bandpass microstrip filter with flexible passband assignment
Authors: Liang Fei , Luo Bin , Lu Wen‐Zhong 
Published: June 2011

AbstractA novel approach for designing triple‐bandpass filters has been presented in this letter.The triple‐bandpass filters are constructed by stepped impedance resonators and common half‐wavelength resonators. The stepped‐impedance resonators operate at the first and third passband and some coupled resonators are introduced to increase the degrees of freedom in extracting coupling coefficients of the first and third passband. The other resonators are designed to operate at the second passband. This structure improves design freedom to fit easily the specific coupling coefficients at all passbands simultaneously and the locations of each passband can also be tuned in a large region. To verify the presented concept, two experimental examples of filters with a triple‐band Chebyshev and triple‐band quasi‐elliptic response operating at 2.4, 3.6, and 5.2 GHz was designed and fabricated with microstrip technology. The measured results are in good agreement with the full‐wave simulation results. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26207
Full‐wave analysis of a microwave rectifying circuit using finite difference time domain algorithm
Authors: Cai Peng , Yang Xue‐Xia , Huang Jian , Zhang Yong , Chen Bin , Guan Xuehui 
Published: June 2011

AbstractThis article presents a study on calculating the conversion efficiency of a microwave rectifying circuit by using finite difference time domain (FDTD) algorithm. To properly descript the lumped device in FDTD algorithm, the nonlinear lumped network (NL2N)‐FDTD method is further extended to model Schottky diode placed across multiple FDTD cells. As a result, a group of formulae are obtained and applied to analyze a typical microwave rectifying circuit, including a nonlinear lumped device of Schottky diode HSMS‐282. The good agreement between FDTD analysis results and ADS simulated ones illustrates the validation of the derived formulae and method. This FDTD analytical method can be used to design and optimize rectifying circuits with high radio frequency–direct current conversion efficiency. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26209
Design and implementation of second‐order microwave integrators
Authors: Tsai Lin‐Chuan , Fang Han‐Sheng 
Published: June 2011

AbstractIn this letter, we propose the second‐order integrators in the Z domain; the second‐order integrators are obtained by interpolating the traditional Simpson's‐ and trapezoidal‐rule integrators. This formulation, in conjunction with the representations of transmission‐line elements in the Z domain, leads to the transmission‐line configuration that is eligible for a microwave integrator. We implement second‐order integrators in the microstrip format that has an operating frequency up to 8.5 GHz. The frequency responses of the second‐order integrators were measured to validate this new formulation. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26210
Broadband planar antenna with T‐shaped strip and capacitively coupled shorted strip
Authors: Kim Woo‐Su , Yoon Cheol , Oh Soon‐Soo , Kang Suk‐Youb , Park Hyo‐Dal 
Published: June 2011

AbstractThis letter describes a broadband planar antenna embedded in LTE700/GSM handheld terminals. The antenna consists of a T‐shaped strip fed by a 50‐Ω coaxial cable and a shorted strip excited by capacitive coupling. The capacitively coupled shorted strip shows the resonance at the lower frequency band, and the T‐shaped strip presents good matching at the higher frequency band, because the characteristics of input impedance are affected by the capacitive coupling. The proposed antenna was simulated and fabricated. The measured bandwidth based on 3:1 VSWR was 0.62–1.53 GHz, which covers the frequencies used for LTE700, GSM800/850/900 mobile communications as well as the military applications. This antenna would be also useful for broadband wireless communications using the technique such as software‐defined radio or cognitive radio. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26211
New microstrip fractal‐shaped square patch resonators filters
Authors: La Dong‐sheng , Lu Ying‐hua , Liu Ning , Cui Dong‐nuan , Zhang Jin‐ling 
Published: June 2011

AbstractThis article proposes and optimizes two types of band‐pass filters using fractal‐shaped square resonators. The filters have many remarkable advantages by using etched fractal‐shaped defected structures in the square patch resonators, such as compact size, high selectivity, and simple structure. The resonant characteristics of the filters are reported and can be adjusted by changing the parameters of the fractal‐shaped structures. Good agreement between the simulation results and the measurement results is achieved. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26212
Monopole antenna based on the modified ground plane for wireless local‐area network application
Authors: Jiang Wen , Gong Shu‐Xi , Yu Song‐Tao 
Published: June 2011

AbstractA monopole antenna with modified ground plane is presented for 2.4 and 5 GHz wireless local area network applications in this article.A trapezoid patch and a quasifractal slotted patch are printed on two FR‐4 dielectric substrates as the radiator and the ground plane of the antenna, respectively. The element of the quasifractal slot structure is a circular ring with four branches. The radiation characteristics are simulated and experimentally verified, and the results show that the proposed antenna has good radiation performance. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26216
Design of microstrip‐fed monopole antenna with two branch strips and a rectangular slit ground for dual‐band WLAN operations
Authors: Yoon Joong Han , Oh Sang Jin , Kim Woo Su 
Published: June 2011

AbstractA dual‐band planar antenna that was developed for wireless local area network (WLAN) application is presented in this article.The proposed antenna, which has two strip lines for resonance and a rectangular ring strip for matching, was designed to cover the popular frequency spectra of the 2.4 and 5 GHz WLAN bands. Also, an asymmetric ground and a rectangular slit in the ground are introduced to enhance the performance of the proposed antenna. The proposed antenna, which is capable of dual‐frequency operation, is fed by a strip line. The obtained numerical results agree well with the experiment data. It was validated that the configuration can meet the demands of WLAN systems and effectively enhanced the impedance bandwidth to 16.8% for the lower band and 58.14% for the upper band when VSWR < 2. This article also presents and discusses the 2D radiation patterns and gains according to the results of the experiment. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26225
UWB true‐time‐delay lines inspired by CRLH TL unit cells
Authors: Zhang J. , Cheung S.W. , Yuk T.I. 
Published: June 2011

AbstractThis article presents the design of ultra‐wideband (UWB) true‐time‐delay lines (TTDLs) operating in microwave frequency.The design is inspired by the use of composite right/left‐handed transmission line (CRLH TL) unit cells as the true‐time‐delay elements to obtain large time delay. A rotated version of the CRLH TL unit cell is used to achieve UWB operation. A periodic microstrip line (PML) employing a sawtooth‐shaped periodic pattern is used to further increase the time delay. For comparison, TTDLs using the conventional CRLH TL unit cells, the PML and the right‐handed transmission line (RH TL) are also designed, optimized and fabricated. Simulation and measurement results show that, for a same length of 60 mm, our proposed TTDL has an ultrawide operating bandwidth and much larger time delay than those of the PML and RH TL ones. Moreover, it has the advantages of high return loss and low insertion loss. Finally, for easily fitting to practical circuits which normally occupy rather even widths and lengths on the printed circuit boards, the proposed straight UWB TTDL is bent to form different shapes such as circular, rectangular and meander. Results show that the performance of the TTDL is not degraded by bending into these shapes. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26228
Ewing sarcoma/primitive neuroectodermal tumor arising from the adrenal gland in an adolescent
Authors: Stephenson Jacob , Gow Kenneth W. , Meehan John , Hawkins Douglas S. , Avansino Jeffrey 
Published: June 2011

AbstractWe review the case of an adolescent who presented with flank pain, fatigue and a discrete nonfunctioning adrenal lesion which was found to be an adrenal Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET). The patient was treated with a minimally invasive adrenalectomy as a component of multimodal therapy, including seven courses of chemotherapy and whole abdominal radiation. She is currently disease free 14 months after the operation and 3 months off therapy. Pediatr Blood Cancer 2011; 57: 691–692. © 2011 Wiley‐Liss, Inc.
Gel‐based proteomics analysis of the heterogeneity of 20S proteasomes from four human pancreatic cancer cell lines
Authors: Wang Xinli , Zhao Zhiyun , Luo Yuanming , Chen Guoqiang , Li Zhili 
Published: June 2011

AbstractPurpose: The 20S proteasome is a multicatalytic protein complex, which plays a major role in intracellular protein degradation. In mammalian cells, it consists of 28 subunits arranged in four stacked rings (α1‐7β1‐7β1‐7α1‐7). The aim of this study is to characterize and compare subunit composition and heterogeneity (or subtypes) of the 20S proteasome from four human pancreatic cancer cell lines.Experimental design: To study subunit compositions and heterogeneity of 20S proteasome from human pancreatic cancer cell lines, in the present study, 20S proteasome from four different pancreatic cancer cell lines (SW1990, a human exocrine adenocarcinoma, derived from spleen metastasis; PANC‐1, a human ductal carcinoma in situ; BxPC‐3, a human ductal carcinoma in situ; and CFPAC‐1, a human ductal adenocarcinoma, derived from liver metastasis) were subjected to a gel‐based proteomics analysis, respectively.Results: It was found that the differences in the subunit compositions and subtypes of the 20S proteasomes among four pancreatic cancer cell lines exist. Gel‐based proteomics analysis showed that more than 60 subunits spots were separated and identified by MS. Our study revealed the presence of various isoforms for each of the subunits and different subtypes of the 20S proteasome. The significant differences among four cell lines are the relative abundances of immunoproteasome subunits, β1i and β2i, indicating that different subtypes of immunoproteasome among four cell lines exist.Conclusions and clinical relevance: The 20S proteasome from four human pancreatic cancer cell lines was characterized. The different expression levels of immunoproteasome subunits, β1i and β2i, indicate that the 20S proteasome may have different subtypes among four cell lines, which may be related to cancer cell property and be useful for the establishment of personalized therapy using proteasome inhibitors in future.
Acute bacterial inflammation of the mouse prostate
Authors: Boehm Bayli J. , Colopy Sara A. , Jerde Travis J. , Loftus Christopher J. , Bushman Wade 
Published: June 2011

AbstractBACKGROUNDProstatic inflammation is gaining increasing attention as a potential etiologic factor in prostate cancer, benign prostatic hyperplasia, lower urinary tract symptoms, and CPPS. This study was performed to address the need for a well characterized model of acute prostatic inflammation that may be used to study the effect of acute inflammation on epithelial and stromal cell proliferation, voiding behavior, and neurovascular physiology.METHODSUropathogenic E. coli 1677 was instilled transurethrally into adult C57BL/6J male mice. Prostates were analyzed at 1, 2, 3, 5, 7, or 14 days post‐instillation and compared to saline‐instilled and naïve controls. Time course and severity of inflammation were characterized by the quantity and type of inflammatory infiltrate present, hemorrhage, proliferation, and reactive hyperplasia. RT‐PCR was performed to characterize inflammatory mediators including IL‐1α, IL‐1β, IL‐1RA, IL‐18, IL‐6, IL‐10, IL‐8, TNFα, and COX‐2.RESULTSInflammation was evident in all lobes of the prostate with the DLP most severely affected. Infection consistently led to a significant increase in neutrophils and macrophages in the early stages of prostate infection, followed by lymphocytic inflammation at the later time points. Inflammation was accompanied by induction of several inflammatory genes, including IL‐1 family members, IL‐6, and COX‐2, and induced a significant increase in epithelial proliferation and reactive hyperplasia in all three prostate lobes.CONCLUSIONSTransurethral inoculation of uropathogenic E. coli 1677 reliably infects the mouse prostate, produces a significant inflammatory response, and induces quantifiable epithelial proliferation and reactive hyperplasia. Prostate 72:307–317, 2012. © 2011 Wiley Periodicals, Inc.
Does absolute neutrophil count predict high tumor grade in African‐American men with prostate cancer?
Authors: Sadeghi Neda , Badalato Gina M. , Hruby Gregory , Grann Victor , McKiernan James M. 
Published: June 2011

AbstractBACKGROUNDAfrican‐Americans (AA) are at risk for benign ethnic neutropenia (BEN), which has been implicated as a potential source of disparity in cancer outcomes among AAs. Since AAs with prostate cancer (PCa) are more likely to have aggressive pathological features, this investigation sought to determine if absolute neutrophil count (ANC) is associated with adverse pathologic findings at radical prostatectomy (RP) within a cohort of AA men.METHODSA single‐institution, retrospective review was conducted of all AA patients undergoing RP who had a pre‐operative CBC with differential and known RP pathology. Neutropenia was defined as ANC ≤1.5 × 109/L (1.5). Clinical and pathologic variables were characterized for the study cohort, and Cox regression and Kaplan–Meier analyses performed to evaluate the association between ANC and adverse pathology.RESULTSA total of 336 patients were included, and 18 patients (5.4%) had ANC ≤1.5. Mean age was 59.8 ± 7.5 years; mean follow‐up time 47.4 ± 43.3 months. Neutropenic patients had significantly higher clinical stages and pathologic Gleason scores (P < 0.05). On multivariable analysis, ANC ≤1.5 was significantly predictive of high tumor grade (HR 1.22, CI 1.01–1.48).CONCLUSIONSNeutropenia in AAs predicts high tumor grade at prostatectomy. Further studies are necessary to further characterize the importance of these findings with regard to the pathogenesis of PCa, particularly as it relates to the AA population. Prostate 72:386–391, 2012. © 2011 Wiley Periodicals, Inc.