bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring public health researchers’ approaches, barriers, and needs regarding dissemination: A mixed-methods exploration
Authors: Nieuwland Alicia , O’Mara Jillian Rose , Mackenbach Joreintje Dingena 
Published: April 2024

Abstract

Background:
Although there is growing attention to research translation, dissemination practices remain underdeveloped. This study aimed to gain insights into the dissemination approaches, barriers for dissemination, and needs for dissemination support of public health researchers of the Amsterdam Public Health (APH) research institute.

Methods:
A concurrent mixed-methods design was used, collecting quantitative and qualitative data through a survey and qualitative data from interviews. Researchers of the Health Behaviors and Chronic Diseases (HBCD) research line of APH were approached via email with a link to an online survey. For the interviews, we aimed to balance researchers in terms of career phase and position. Data were analyzed through descriptive statistics and thematic content analysis.

Results:
HBCD researchers primarily rely on traditional approaches for dissemination, e.g. academic journals (93%), conferences (93%), and reports to funders (71%). Social media (67%) was also frequently mentioned. Dissemination is often prioritized late due to time constraints and competing priorities. Researchers mentioned a lack of time, money, knowledge, and skills but also limited awareness of available support as barriers. A need for more resources, education, and a shift in mindset was expressed, suggesting a comprehensive inspiring platform and stronger in-house connections as solutions.

Conclusion:
HBCD researchers emphasized the importance of dedicated time and budget for dissemination, as well as other forms of institutional support. Overall, there is a need for a shift in mindset, more educational initiatives, greater integration of dissemination into researchers’ roles, the establishment of a comprehensive inspiring platform, and stronger in-house connections to support dissemination efforts.
The Politics of Doulas: Black Feminist Collective Action in Response to “Birthing While Black”
Authors: Fast Jina 
Published: April 2024

AbstractA central function of the Black Lives Matter (BLM) movement in the United States has been to center and express the lived experiences of Black people within the social and political framework of white supremacy. Regarding reproductive justice, BLM, as well as organizations like the Black Mamas Matter Alliance and Sistersong, have drawn political attention to the oppressive parameters existing for pregnant people “birthing while Black.” Attention to disparities in health and birth outcomes for Black persons has necessary positive effects, such as the ability to produce data on the deleterious effects of anti-Blackness. However, discourses surrounding Black birthing persons can function to obfuscate the collective action undertaken by Black women and non-Black women of color. In this paper, I argue the hyper-focus on the problems Black pregnant/birthing persons face has at least four issues: (1) it encourages an ontological collapse wherein Black birthers are positioned as problems, rather than human beings facing problems; (2) obscures the collective action and care Black women undertake to support one another; (3) results in state solutions that rely on underpaid and volunteer labor of Black and non-Black women of color; and (4) focuses myopically on the time period of pregnancy and birthing for Black persons.
Levels of selection and macroevolution in organisms, colonies, and species
Authors: Simpson Carl , Halling Andrea , Leventhal Sarah 
Published: April 2024

Abstract
The fitness of groups is often considered to be the average fitness among constituent members. This assumption has been useful for developing models of multilevel selection, but its uncritical adoption has held back our understanding of how multilevel selection actually works in nature. If group fitness is only equal to mean member fitness, then it is a simple task to erode the importance of group-level selection in all multilevel scenarios—species selection could then be reduced to organismal selection as easily as group selection can. Because selection from different levels can act on a single trait, body size, for example, there must be a way to translate one level of fitness to another. This allows the calculation of the contributions of selection at each level. If high-level fitness is not a simple function of member fitness, then how do they interlace? Here we reintroduce Leigh Van Valen’s argument for the inclusion of expansion as a component of fitness. We show that expansion is an integral part of fitness even if one does not subscribe to the energetic view of fitness from which Van Valen originally derived it. From a hierarchical perspective, expansion is the projection of demographic fitness from one level to the next level up; differential births and deaths at one level produce differential expansion one level above. Including expansion in our conceptual tool kit helps allay concerns about our ability to identify the level of selection using a number of methods as well as allowing for the various forms of multilevel selection to be seen as manifestations of the same basic process.
Consumption of ultra-processed foods and mental health of pregnant women from the South of Brazil
Authors: Meller Fernanda Oliveira , Costa Caroline dos Santos , Quadra Micaela Rabelo , Miranda Vanessa Iribarrem Avena , Eugênio Fernanda Daminelli , da Silva Tamara Justin , Teixeira Maria Vitória Rodrigues , Schäfer Antônio Augusto 
Published: April 2024

AbstractThe objective of this study is to evaluate the association between the consumption of ultra-processed foods (UPF) and the mental health of pregnant women from the South of Brazil. This is a cross-sectional study carried out in Criciúma, Brazil, through face-to-face interviews, from April to December 2022. Pregnant women aged 18 or older who underwent prenatal care in the forty-eight basic health care units of the municipality and who were in their third trimester of pregnancy were included. High consumption of UPF was considered as six or more items or subgroups of UPF consumed on the day before the interview, using the Nova-UPF screener. The mental health variables were depressive symptoms, stress, sadness and anxiety. Crude and adjusted analyses were conducted using the Fisher’s exact test and the Poisson regression with robust variance. In total, 428 pregnant women were studied; most of them were aged between 20 and 25 years and were white. Pregnant women who presented high consumption of UPF were 1·42-fold (95 % CI 1·06, 1·92) more likely to experience anxiety and presented a prevalence 56 % (95 % CI 1·18, 2·07) higher of stress when compared with those who did not present high consumption of UPF. The prevalence of depressive symptoms and feelings of sadness was 1·31-fold (95 % CI 1·08, 1·60) and 3·41-fold (95 % CI 1·77, 6·58) higher among those with high consumption of UPF, respectively. The results suggest that diet quality is associated with the mental health of pregnant women. Promoting joint actions focused on food and nutritional education, and mental health, for pregnant women, is necessary.
Successful ablation of premature ventricular contractions originating from the posterior-superior process of the left ventricle approaching from the right atrium in a 13-year-old male
Authors: Nakagawa Ryo , Yoshida Yoko , Suzuki Tsugutoshi 
Published: April 2024

AbstractThis is a case of a 13-year-old male with frequent premature ventricular contractions with QRS configurations of the left superior axis and left bundle branch block, which originated from the posterior–superior process of the left ventricle. Premature ventricular contractions were successfully eliminated by delivering radiofrequency energy to the inferior wall of the right atrium without causing either junctional rhythm or atrioventricular block. Ventricular arrhythmias originating from this site have been sporadically reported in adults; however, this is the first report in a child.
Individual Maxim Tokens, not Abstract Maxim Types
Authors: Kahn Samuel 
Published: April 2024

AbstractI argue that Kant’s Categorical Imperative should be applied to individual maxim tokens rather than abstract maxim types. The article is divided into five sections. In the first, I explain my thesis. In the second, I show that my thesis disagrees with Rawls. In the third, I argue for my thesis on the basis of the wording of the Categorical Imperative and on the basis of considerations about autonomy. In the fourth, I argue for my thesis on the basis of considerations about the ‘ought implies can’ principle. In the fifth, I provide a summary of the main argumentative moves and also explain some of the philosophical advantages of my thesis.
The Ostroms on self-governance: the importance of cybernetics
Authors: Lewis Paul , Aligica Paul Dragos 
Published: April 2024

AbstractThis paper reveals a novel and perhaps surprising ingredient in the mix of influences that inspired and informed the work of Elinor and Vincent Ostrom on self-governance: cybernetics, understood as a theory of control via feedback mechanisms. Based on this crucial insight, the paper portrays self-governance as involving an architecture of multiple levels of so-called ‘second order’ feedback mechanisms. Such compounded systems of organization are the key to understanding any self-governance process and the paper argues that their intrinsic logic provides a critical link between the work of the Ostroms and the public choice and constitutional political economy perspectives on institutional order. The paper thereby offers both a fresh perspective on the Ostromian view of self-governance and also of also of governance theory in general.
(Small D-democratic) vacation, all I ever wanted? The effect of democratic backsliding on leisure travel in the American states
Authors: Miller David R. , Smith Serena D. 
Published: April 2024

AbstractAs many American states have considered policies consistent with democratic backsliding in recent years, political elites and scholars have speculated on the consequences of these policies for political behavior. We examine the effect of backsliding policies on Americans’ preferences over leisure travel destinations; because vacationing is transitory, this focus allows us to isolate the role of individuals’ democratic predispositions and values in preference formation from the implications of these policies on their self-interest that they would experience from living under those policies themselves. Through pre-registered conjoint and vignette survey experiments, we find that Americans, and especially Democrats, express less interest in vacationing in states that recently adopted backsliding policies. Our results spotlight an accountability mechanism by which Americans may sanction backsliding states, though the modest magnitude of these sanctions – less than 1% of backsliding states’ gross domestic products – may not deter backsliding behavior on their own.
Modeling the Cross‐Sectional Dynamics of Tidal Sandbanks in Sediment‐Scarce Conditions
Authors: van Veelen T. J. , Roos P. C. , Hulscher S. J. M. H. 
Published: April 2024

AbstractTidal sandbanks are large‐scale dynamic bedforms that consist of sandy sediment. They have been observed in shallow seas with varying sediment supply, including sediment‐scarce environments like the Flemish Banks, Zeeland Banks, and Norfolk Banks. However, we do not yet understand how scarcity affects sandbank evolution. Therefore, we have developed an idealized nonlinear process‐based model with the aim of studying cross‐sectional shape and migration under sediment‐scarce conditions. Scarcity is included through a non‐erodible layer from which no sediment can be entrained. Our results show that bank height and width decrease when the sediment budget decreases. The bank height is more sensitive to scarcity than bank width. Furthermore, sand scarcity decreases (and may even reverse) bank asymmetry and increases migration rate when a residual current is present. The migration rate attains a maximum for a specific sediment budget, which is controlled by the ratio of the cross‐sectional area of the sandbank and the tide‐averaged sediment flux. Our findings show that sandbank dynamics are strongly affected by scarcity, which is critical for seas with receding sediment stocks (e.g., through extraction).
The Irminger Gyre as a Key Driver of the Subpolar North Atlantic Overturning
Authors: Sanchez‐Franks A. , Holliday N. P. , Evans D. G. , Fried N. , Tooth O. , Chafik L. , Fu Y. , Li F. , de Jong M. F. , Johnson H. L. 
Published: April 2024

AbstractThe lower limb of the Atlantic meridional overturning circulation (AMOC) is the equatorward flow of dense waters formed through the cooling and freshening of the poleward‐flowing upper limb. In the subpolar North Atlantic (SPNA), upper limb variability is primarily set by the North Atlantic Current, whereas lower limb variability is less well understood. Using observations from a SPNA mooring array, we show that variability of the AMOC's lower limb is connected to poleward flow in the interior Irminger Sea. We identify this poleward flow as the northward branch of the Irminger Gyre (IG), accounting for 55% of the AMOC's lower limb variability. Over 2014–2018, wind stress curl fluctuations over the Labrador and Irminger Seas drive this IG and AMOC variability. On longer (>annual) timescales, however, an increasing trend in the thickness of intermediate water, from 2014 to 2020, within the Irminger Sea coincides with a decreasing trend in IG strength.
MED15 is upregulated by HIF-2α and promotes proliferation and metastasis in clear cell renal cell carcinoma via activation of SREBP-dependent fatty acid synthesis
Authors: Hua Xiaoliang , Ge Shengdong , Zhang Li , Jiang Qing , Chen Juan , Xiao Haibing , Liang Chaozhao 
Published: April 2024

AbstractEmerging evidence has highlighted that dysregulation of lipid metabolism in clear cell renal cell carcinoma (ccRCC) is associated with tumor development and progression. HIF-2α plays an oncogenic role in ccRCC and is involved in abnormal lipid accumulation. However, the underlying mechanisms between these two phenomena remain unknown. Here, MED15 was demonstrated to be a dominant factor for HIF-2α-dependent lipid accumulation and tumor progression. HIF-2α promoted MED15 transcriptional activation by directly binding the MED15 promoter region, and MED15 overexpression significantly alleviated the lipid deposition inhibition and malignant tumor behavior phenotypes induced by HIF-2α knockdown. MED15 was upregulated in ccRCC and predicted poor prognosis. MED15 promoted lipid deposition and tumor progression in ccRCC. Mechanistic investigations demonstrated that MED15 acts as SREBP coactivator directly interacting with SREBPs to promote SREBP-dependent lipid biosynthesis enzyme expression, and promotes SREBP1 and SREBP2 activation through the PLK1/AKT axis. Overall, we describe a molecular regulatory network that links MED15 to lipid metabolism induced by the SREBP pathway and the classic HIF-2α pathway in ccRCC. Efforts to target MED15 or inhibit MED15 binding to SREBPs as a novel therapeutic strategy for ccRCC may be warranted.
METTL14 promotes neuroblastoma formation by inhibiting YWHAH via an m6A-YTHDF1-dependent mechanism
Authors: Wang Jianwei , Yin Hongli , Li Gen , Wu Di , Xu Yunyun , Chen Yanling , Wang Xiaodong , Xing Yujiao , Zhang Ting , Fei Danhong , Yang Pengcheng , Fang Fang , Tao Yanfang , Li Xiaolu , Yu Juanjuan , Yang Yang , Li Zhiheng , Shi Lei , Zhang Zimu , Pan Jian 
Published: April 2024

AbstractNeuroblastoma (NB) is a common childhood tumor with a high incidence worldwide. The regulatory role of RNA N6-methyladenosine (m6A) in gene expression has attracted significant attention, and the impact of methyltransferase-like 14 (METTL14) on tumor progression has been extensively studied in various types of cancer. However, the specific influence of METTL14 on NB remains unexplored. Using data from the Target database, our study revealed significant upregulation of METTL14 expression in high-risk NB patients, with strong correlation with poor prognosis. Furthermore, we identified ETS1 and YY1 as upstream regulators that control the expression of METTL14. In vitro experiments involving the knockdown of METTL14 in NB cells demonstrated significant inhibition of cell proliferation, migration, and invasion. In addition, suppressing METTL14 inhibited NB tumorigenesis in nude mouse models. Through MeRIP-seq and RNA-seq analyses, we further discovered that YWHAH is a downstream target gene of METTL14. Mechanistically, we observed that methylated YWHAH transcripts, particularly those in the 5′ UTR, were specifically recognized by the m6A “reader” protein YTHDF1, leading to the degradation of YWHAH mRNA. Moreover, the downregulation of YWHAH expression activated the PI3K/AKT signaling pathway, promoting NB cell activity. Overall, our study provides valuable insights into the oncogenic effects of METTL14 in NB cells, highlighting its role in inhibiting YWHAH expression through an m6A-YTHDF1-dependent mechanism. These findings also suggest the potential utility of a biomarker panel for prognostic prediction in NB patients.
Tspan protein family: focusing on the occurrence, progression, and treatment of cancer
Authors: Zhang Huhu , Song Qinghang , Shang Kaiwen , Li Ya , Jiang Liangqian , Yang Lina 
Published: April 2024

AbstractThe Tetraspanins (Tspan) protein family, also known as the tetraspanin family, contains 33 family members that interact with other protein molecules such as integrins, adhesion molecules, and T cell receptors by forming dimers or heterodimers. The Tspan protein family regulates cell proliferation, cell cycle, invasion, migration, apoptosis, autophagy, tissue differentiation, and immune response. More and more studies have shown that Tspan proteins are involved in tumorigenesis, epithelial-mesenchymal transition, thrombosis, tumor stem cell, and exosome signaling. Some drugs and microRNAs can inhibit Tspan proteins, thus providing new strategies for tumor therapy. An in-depth understanding of the functions and regulatory mechanisms of the Tspan protein family, which can promote or inhibit tumor development, will provide new strategies for targeted interventions in the future.
Neural étendue expander for ultra-wide-angle high-fidelity holographic display
Authors: Tseng Ethan , Kuo Grace , Baek Seung-Hwan , Matsuda Nathan , Maimone Andrew , Schiffers Florian , Chakravarthula Praneeth , Fu Qiang , Heidrich Wolfgang , Lanman Douglas , Heide Felix 
Published: April 2024

AbstractHolographic displays can generate light fields by dynamically modulating the wavefront of a coherent beam of light using a spatial light modulator, promising rich virtual and augmented reality applications. However, the limited spatial resolution of existing dynamic spatial light modulators imposes a tight bound on the diffraction angle. As a result, modern holographic displays possess low étendue, which is the product of the display area and the maximum solid angle of diffracted light. The low étendue forces a sacrifice of either the field-of-view (FOV) or the display size. In this work, we lift this limitation by presenting neural étendue expanders. This new breed of optical elements, which is learned from a natural image dataset, enables higher diffraction angles for ultra-wide FOV while maintaining both a compact form factor and the fidelity of displayed contents to human viewers. With neural étendue expanders, we experimentally achieve 64 × étendue expansion of natural images in full color, expanding the FOV by an order of magnitude horizontally and vertically, with high-fidelity reconstruction quality (measured in PSNR) over 29 dB on retinal-resolution images.
hoxc12/c13 as key regulators for rebooting the developmental program in Xenopus limb regeneration
Authors: Kawasumi-Kita Aiko , Lee Sang-Woo , Ohtsuka Daisuke , Niimi Kaori , Asakura Yoshifumi , Kitajima Keiichi , Sakane Yuto , Tamura Koji , Ochi Haruki , Suzuki Ken-ichi T. , Morishita Yoshihiro 
Published: April 2024

AbstractDuring organ regeneration, after the initial responses to injury, gene expression patterns similar to those in normal development are reestablished during subsequent morphogenesis phases. This supports the idea that regeneration recapitulates development and predicts the existence of genes that reboot the developmental program after the initial responses. However, such rebooting mechanisms are largely unknown. Here, we explore core rebooting factors that operate during Xenopus limb regeneration. Transcriptomic analysis of larval limb blastema reveals that hoxc12/c13 show the highest regeneration specificity in expression. Knocking out each of them through genome editing inhibits cell proliferation and expression of a group of genes that are essential for development, resulting in autopod regeneration failure, while limb development and initial blastema formation are not affected. Furthermore, the induction of hoxc12/c13 expression partially restores froglet regenerative capacity which is normally very limited compared to larval regeneration. Thus, we demonstrate the existence of genes that have a profound impact alone on rebooting of the developmental program in a regeneration-specific manner.
Multi-omics analysis reveals COVID-19 vaccine induced attenuation of inflammatory responses during breakthrough disease
Authors: Drury Ruth E. , Camara Susana , Chelysheva Irina , Bibi Sagida , Sanders Katherine , Felle Salle , Emary Katherine , Phillips Daniel , Voysey Merryn , Ferreira Daniela M. , Klenerman Paul , Gilbert Sarah C. , Lambe Teresa , Pollard Andrew J. , O’Connor Daniel 
Published: April 2024

AbstractThe immune mechanisms mediating COVID-19 vaccine attenuation of COVID-19 remain undescribed. We conducted comprehensive analyses detailing immune responses to SARS-CoV-2 virus in blood post-vaccination with ChAdOx1 nCoV-19 or a placebo. Samples from randomised placebo-controlled trials (NCT04324606 and NCT04400838) were taken at baseline, onset of COVID-19-like symptoms, and 7 days later, confirming COVID-19 using nucleic amplification test (NAAT test) via real-time PCR (RT-PCR). Serum cytokines were measured with multiplexed immunoassays. The transcriptome was analysed with long, short and small RNA sequencing. We found attenuation of RNA inflammatory signatures in ChAdOx1 nCoV-19 compared with placebo vaccinees and reduced levels of serum proteins associated with COVID-19 severity. KREMEN1, a putative alternative SARS-CoV-2 receptor, was downregulated in placebo compared with ChAdOx1 nCoV-19 vaccinees. Vaccination ameliorates reductions in cell counts across leukocyte populations and platelets noted at COVID-19 onset, without inducing potentially deleterious Th2-skewed immune responses. Multi-omics integration links a global reduction in miRNA expression at COVID-19 onset to increased pro-inflammatory responses at the mRNA level. This study reveals insights into the role of COVID-19 vaccines in mitigating disease severity by abrogating pro-inflammatory responses associated with severe COVID-19, affirming vaccine-mediated benefit in breakthrough infection, and highlighting the importance of clinically relevant endpoints in vaccine evaluation.