bluuebunny/crossref_metadata_2025_split huggingface dataset:
EMPIRICAL ANALYSIS OF SPECULATIVE ATTACKS WITH CONTRACTIONARY REAL EFFECTS
Authors: Arciniegas Rueda Ismael 
Published: May 2012

SUMMARYThe effects of a currency crisis on a country's economy depend on nonlinear relations among several variables that characterize the economic, financial, legal and socio‐political structure of the country at the onset of the crisis. Those effects can be associated with contractions or expansions in output. Historically, contractionary speculative attacks are more frequent. This paper uses a parametric censored heteroscedastic TOBIT model to empirically analyse how different economic and financial variables determine the real effects of a contractionary speculative attack. Variables describing the banking sector, the international trade, the severity of the crisis and foreign interest rates are found to be significant in explaining the size of currency crises' contractionary real effects. The TOBIT's results are compared with alternative modelling strategies. Copyright © 2012 John Wiley & Sons, Ltd.
Aggregation and inactivation of pancreatic cystatin by riboflavin‐derived singlet oxygen and flavin triplet state: Polyphenols as preventive agents
Authors: Priyadarshini Medha , Khan Mohd. Shahnawaz , Bano Bilqees 
Published: May 2012

AbstractCaprine pancreatic thiol proteinase inhibitor (PTPI) a cystatin superfamily variant has high affinity for cysteine proteinases providing tight regulation of their proteolytic potential. Oxidative stress buildup in various pancreatic pathologies worsens the disease course often by disturbing the delicate balance between proteinases and their inhibitors. We aimed to study the effect of reactive oxygen species (ROS) on PTPI and to determine the potency of caffeic acid, curcumin and quercetin as agents against the inflicted damage. Fluorescence spectroscopy, polyacrylamide gel electrophoresis, and papain inhibitory assay revealed that photoilluminated riboflavin severely challenged the functional and structural integrity of the inhibitor. Three hundred and fifty micromolar affeic acid or quercetin prevented the damage. Curcumin, however, failed to reverse the changes completely. Conclusively, PTPI rendered dysfunctional by ROS may explain the increased necrotic damage to the host tissue. Also, dietary antioxidants can reverse the riboflavin‐induced protein damage providing an economic and safe anti‐ROS therapy. © 2012 Wiley Periodicals, Inc. J Biochem Mol Toxicol 26:187–192, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.20423
Host response to xenograft ECM implantation is not different between the shoulder and body wall sites in the rat model
Authors: Leigh Diane R. , Mesiha Mena , Baker Andrew R. , Walker Esteban , Derwin Kathleen A. 
Published: May 2012

AbstractIn the context of tendon and ligament repair, mechanical loading and the presence of joint synovial fluid are known to profoundly influence the form and function of the repair tissue and potentially the host response to biomaterials. Previously, we demonstrated that a xenograft extra cellular matrix (ECM) scaffold implanted in the rat shoulder elicited a unique host response from that seen in the body wall. However, the host response to xenografts implanted in shoulders with a tendon/capsule injury was not different from xenografts implanted in shoulders with no injury. In the current study, we hypothesized that varying clinically relevant surgical and environmental factors would introduce significant differences in host response to xenograft implantation at the shoulder. Contrary to our hypothesis, we found no significant differences in host response between any shoulder implantation conditions or between shoulder and body wall implantation in the rat model. These findings suggest that there is no advantage to using an orthotopic shoulder model to investigate the host response to rotator cuff scaffold materials in the rat model, and due to the insensitivity of its host response to various clinically relevant surgical conditions, may suggest that the rat does not provide a surrogate for directly translating the host response to biomaterials to the human application. © 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 30:1725–1731, 2012
The younger dryas cooling in northeast Germany: summer temperature and environmental changes in the Friedländer Groβe Wiese region
Authors: van Asch Nelleke , Kloos Marjan E. , Heiri Oliver , de Klerk Pim , Hoek Wim Z. 
Published: May 2012

AbstractA lake sediment record from the Friedländer Groβe Wiese in northeast Germany was studied to reconstruct summer temperature changes associated with changes in vegetation development during the Weichselian Lateglacial. The record was analysed for pollen, chironomids, and oxygen and carbon isotopes of lake marl. The combination of radiocarbon dates, the presence of the Laacher See Tephra and correlation of lithological and palynological changes with other records from the region indicated that the record encompassed the Allerød to the early Holocene. Pollen assemblages reflect development of birch and later pine‐dominated forests during the Allerød, comparable to other sites in the region. Chironomid‐inferred mean July air temperatures (C‐IT) for this period range between ∼14.0 and 14.8°C. A temporary decrease in C‐IT of ∼1°C, a negative shift in the isotope records, and a minor decline of birch may correspond to Greenland Interstadial 1b. Even though the transition to the Younger Dryas appears to be affected by reworking and redeposition processes, a drop in C‐IT to ∼11.1°C is reconstructed for the later part of the Younger Dryas, while it appears that pine locally persisted in the region. Comparison with a nearby pollen record further indicates a local expansion of wetland grasses during this period. At the transition to the Holocene, C‐IT increased to ∼15.7°C, while birch and pine forests re‐expanded. Copyright © 2012 John Wiley & Sons, Ltd.
Quantification and visualization of flow in the Circle of Willis: Time‐resolved three‐dimensional phase contrast MRI at 7 T compared with 3 T
Authors: van Ooij P. , Zwanenburg J. J. M. , Visser F. , Majoie C. B. , vanBavel E. , Hendrikse J. , Nederveen A. J. 
Published: May 2012

AbstractThe assessment of both geometry and hemodynamics of the intracranial arteries has important diagnostic value in internal carotid occlusion, sickle cell disease, and aneurysm development. Provided that signal to noise ratio (SNR) and resolution are high, these factors can be measured with time‐resolved three‐dimensional phase contrast MRI. However, within a given scan time duration, an increase in resolution causes a decrease in SNR and vice versa, hampering flow quantification and visualization. To study the benefits of higher SNR at 7 T, three‐dimensional phase contrast MRI in the Circle of Willis was performed at 3 T and 7 T in five volunteers. Results showed that the SNR at 7 T was roughly 2.6 times higher than at 3 T. Therefore, segmentation of small vessels such as the anterior and posterior communicating arteries succeeded more frequently at 7 T. Direction of flow and smoothness of streamlines in the anterior and posterior communicating arteries were more pronounced at 7 T. Mean velocity magnitude values in the vessels of the Circle of Willis were higher at 3 T due to noise compared to 7 T. Likewise, areas of the vessels were lower at 3 T. In conclusion, the gain in SNR at 7 T compared to 3 T allows for improved flow visualization and quantification in intracranial arteries. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.
Paraneoplastic lower motor neuronopathy associated with Hodgkin lymphoma
Authors: Flanagan Eoin P. , Sandroni Paola , Pittock sean j. , Inwards David J. , Jones Lyell K. 
Published: May 2012

AbstractIntroduction: Paraneoplastic lower motor neuronopathies have been reported rarely with Hodgkin lymphoma. Methods: We report a case of rapidly progressive motor neuronopathy preceding the diagnosis of Hodgkin lymphoma. Results: A 31‐year‐old woman developed subacute rapidly progressive quadriparesis. Electrodiagnostic studies revealed a severe diffuse disorder of motor neurons and their axons. Symmetric enhancement of the cauda equina motor nerve roots was notable on magnetic resonance imaging scan. Further imaging demonstrated an enlarged supraclavicular lymph node, and biopsy revealed Hodgkin lymphoma. A final diagnosis of paraneoplastic motor neuronopathy was made after investigations for alternative causes of motor neuronopathy were unrevealing. Neurological improvement was seen with combined treatment of the underlying malignancy and intravenous immunoglobulin.Conclusions: Paraneoplastic causes should be considered in the differential diagnosis of subacute motor neuronopathy, as the neurological presentation may precede cancer detection. Combinations of lymphoma treatment and immunotherapy may result in a favorable outcome. Muscle Nerve 46: 823–827, 2012
Nitric oxide prevents atorvastatin‐induced skeletal muscle dysfunction and alterations in mice
Authors: D'Antona Giuseppe , Mascaro Anna , Monopoli Angela , Miglietta Daniela , Ongini Ennio , Bottinelli Roberto 
Published: May 2012

AbstractIntroduction:Myopathy is the most common side effect of statins. Because nitric oxide (NO) has a key role in regulating skeletal muscle function, we studied whether the NO‐donating atorvastatin NCX 6560 could show a better profile on skeletal muscle function and structure compared with atorvastatin.Methods:C57BL/6 mice received atorvastatin 40 mg/kg/day or an equivalent dose of NCX 6560 for 2 months. Muscle function assessed by treadmill test, serum creatine kinase (CK) activity, citrate synthase (CS) activity, and muscle histology were evaluated.Results:Atorvastatin significantly (P < 0.001) reduced muscle endurance, increased serum CK by 6‐fold, and induced muscle fiber atrophy. Conversely, NCX 6560 preserved muscle function, prevented CK increase and did not modify muscle structure. Interestingly, atorvastatin reduced CS activity, a marker for mitochondrial function, in gastrocnemius, diaphragm, and heart, whereas NCX 6560 prevented such decrease.Conclusions:These findings suggest that NO may prevent statin‐induced myopathy. Muscle Nerve, 2013
Improved outcome in pediatric AML due to augmented supportive care
Authors: Jastaniah Wasil , Abrar Mohammed Burhan , Khattab Taha M. 
Published: May 2012

AbstractWe conducted a retrospective review of patients treated following the MRC acute myeloid leukemia (AML) 10 protocol to determine if supportive care measures sequentially introduced by our institution led to a significant improvement in treatment‐related mortality (TRM) in newly diagnosed pediatric patients with AML. Patients were partitioned based on supportive care measures into era1, from 1996 to 2002 (n = 20), and era2, from 2003 to 2011 (n = 40). The introduced supportive care measures reduced the TRM from 23.4% in era1 to 2.5% in era2 (P = 0.034). The results demonstrate that supportive care is a significant factor in determining the outcome of childhood AML. Pediatr Blood Cancer 2012; 59: 919–921. © 2012 Wiley Periodicals, Inc.
The utility of end‐of‐treatment bone marrow aspirates in pediatric acute lymphoblastic leukemia: A quality improvement project
Authors: Gupta Sumit , Crump Hannah L. , Alexander Sarah 
Published: May 2012

AbstractWe reviewed the use, results and costs of end‐of‐treatment bone marrow aspirates (EOTBMAs) performed locally in patients diagnosed with ALL between 2000 and 2005. Of 193 patients, 188(97%) received EOTBMAs. Though 15/188(8.0%) patients experienced relapse at a median time of 1.1 years (range 0.1–4 years), no sign of relapse was detected on any EOTBMA. After communication of results to clinical staff, only 2/17 (12%) of patients with ALL finishing treatment in the subsequent 5 months received an EOTBMA (P < 0.0001). Our results confirm the futility of EOTBMAs in a large contemporary cohort. Disseminating local results may help ensure adherence to best practices. Pediatr Blood Cancer 2012; 59: 1305–1306. © 2012 Wiley Periodicals, Inc.
Concurrent radiation with irinotecan and carboplatin in intermediate‐ and high‐risk rhabdomyosarcoma: A report on toxicity and efficacy from a prospective pilot phase II study
Authors: Dharmarajan Kavita V. , Wexler Leonard H. , Wolden Suzanne L. 
Published: May 2012

AbstractBackgroundIrinotecan is highly active against rhabdomyosarcoma (RMS), yet its tolerability and efficacy in combination with radiation is unknown. We examined local control and toxicities in RMS patients treated with radiotherapy (RT) in combination with radiosensitizing agents irinotecan + carboplatin (I + C).ProcedureFrom 11/2003 to 1/2011, 60 patients were enrolled on a pilot phase II protocol with newly diagnosed intermediate‐ or high‐risk RMS at Memorial Sloan‐Kettering Cancer Center. Induction therapy consisted of two cycles of I + C followed by three cycles of vincristine, doxorubicin, and cyclophosphamide. At week 13, 47 patients received definitive primary‐site RT or post‐operative RT with two concurrent cycles of I + C. Median RT dose was 50.4 Gy (range 30.6–50.4 Gy). Radiation‐related toxicities were evaluated according to the Common Terminology Criteria for Adverse Events, version 3.0.ResultsMedian age of the cohort was 9 years. With median follow‐up of 32 months, 2.5 year actuarial local control was 89%. Among all patients, grades 3 and 4 dermatitis were observed in 11% and 4%, respectively. Among parameningeal, orbit, and other head/neck sites, rates of grades 3 and 4 mucositis were 20% and 10%, respectively. Among abdomen/pelvis sites, 12% developed grade 3 diarrhea and 6% developed grade 3 cystitis. No treatment breaks were necessary.ConclusionsPreliminary results of irinotecan and carboplatin administered with concurrent RT in intermediate‐ and high‐risk RMS demonstrated favorable tolerability, efficacy, and local control. Reduced rates of acute grades 3–4 mucositis were observed when compared with historical results. Pediatr Blood Cancer 2013;60:242–247. © 2012 Wiley Periodicals, Inc.
Relationship of general self‐efficacy with anxiety, symptom severity and quality of life in cancer patients before and after radiotherapy treatment
Authors: Mystakidou Kyriaki , Tsilika Eleni , Parpa Efi , Gogou Pinelopi , Panagiotou Irene , Vassiliou Ioannis , Gouliamos Athanasios 
Published: May 2012

AbstractPurposeTreatment‐related symptoms can increase psychological and physical distress and alter the patient's quality of life. The present study evaluates prospectively treatment‐related symptoms, general self‐efficacy, anxiety and quality of life (QoL) in patients with different types of cancer undergoing external beam radiotherapy (RT) and the relationship of patients' general self‐efficacy with the assessed measures, at the baseline and their absolute change 1 month after the end of the treatment.MethodsThe sample consisted of 90 cancer patients. General self‐efficacy was assessed using the General Perceived Self‐efficacy (GSE). QoL was evaluated using the Linear Analogue Scale Assessment (LASA), anxiety with the Anxiety subscale of the Hospital Anxiety and Depression (HAD) scale, whereas symptom severity and interference were assessed using the MD Anderson Symptom Inventory (MDASI). The instruments were administered first at the beginning of the RT and then 1 month after the completion of the RT.ResultsAt post‐treatment, general self‐efficacy was reduced (28.86 ± 6.42), anxiety scores were elevated (9.56 ± 4.42), QoL scores were reduced (6.74 ± 1.81) and symptoms severity were deteriorated (3.24 ± 2.62). Pre‐treatment and post‐treatment absolute change scores revealed statistically significant negative correlations between general self‐efficacy absolute scores and anxiety (p < 0.0005). Moderate negative correlations between general self‐efficacy absolute scores and symptoms (MDASI symptom severity: p = 0.003, symptom interference: p = 0.002), whereas a low positive correlation was found between general self‐efficacy absolute scores and LASA energy scale (p = 0.048).ConclusionsA sense of self‐efficacy and its relationship with anxiety, symptom distress and quality of life are important factors for patients receiving radiotherapy. Health care professionals need to be aware of anxiety, symptom severity and patient's quality of life prior to treatment initiation. Copyright © 2012 John Wiley & Sons, Ltd.
Comparison of biochemical failure definitions for predicting local cancer recurrence following cryoablation of the prostate
Authors: Pitman Max , Shapiro Edan Y. , Hruby Gregory W. , Truesdale Matthew D. , Cheetham Philippa J. , Saad Shumaila , Katz Aaron E. 
Published: May 2012

AbstractBACKGROUNDVarious definitions of biochemical failure (BF) have been used to predict cancer recurrence following prostate cryoablation. However to date, none of these definitions have been validated for this use. We have reviewed several definitions of BF to determine their accuracy in predicting biopsy‐proven local recurrence following prostate cryoablation.METHODSThe Columbia University Urologic Oncology Database was queried for patients who underwent prostate cryoablation between 1994 and 2010, and who subsequently underwent surveillance biopsy due to clinical suspicion of prostate cancer recurrence. Serial postoperative prostate‐specific antigen (PSA) results were used to determine BF according to various definitions of BF. Biopsy results were used to determine local recurrence. Sensitivity, specificity, positive and negative predictive value, and receiver operating characteristic (ROC) curve area were calculated for each of the BF definitions.RESULTSA total of 110 patients met inclusion criteria for the study. These patients were treated with primary full‐gland (n = 38), primary focal (n = 24), or salvage cryoablation (n = 48). On surveillance biopsy, 66 patients (60%) were found to have locally recurrent prostate cancer. The most accurate BF definition overall was PSA nadir plus 2 ng/ml (Phoenix definition), with sensitivity, specificity, and ROC curve area of 68%, 59%, and 0.64, respectively.CONCLUSIONSOverall, the Phoenix definition best predicted local cancer recurrence following prostate cryoablation. These preliminary data may be useful for researchers evaluating the short‐term efficacy of cryoablation, and for urologists assessing their patients for potential cancer recurrence. Prostate 72:1802–1808, 2012. © 2012 Wiley Periodicals, Inc.
Computational modeling of standard reduction potentials of B12 cofactors
Authors: Kumar Manoj , Galezowski Wlodzimierz , Kozlowski Pawel M. 
Published: May 2012

AbstractDensity functional theory using a variety of functionals (i.e., BP86, B3LYP, B3LYP‐D, B3PW91, PBE1PBE, mPW1PBE, mPW3PBE, and mPW1PW91) in combination with a polarizable continuum solvent model is applied to compute the standard reduction potentials of methylcobalamin (MeCbl) and adenosylcobalamin (AdoCbl) cofactors, respectively. A fairly good agreement between experiment and theory is obtained when the reduction potentials are computed in dimethylforamide solvent using BP86/6‐31+G* level of theory. The computed reduction potentials of MeCbl and AdoCbl cofactors are predicted within 0.1–0.2 V of their experimental values. The reliability of the calibrated protocol is further testified when an acceptable degree of reproducibility (experiment vs. theory) is achieved with regard to the reduction potential of the cob(II)alamin/cob(I)alamin couple. The calibrated theoretical strategy is then exploited to understand the role of the upper axial ligand in governing the reduction potentials of alkylcobalamins. It is noted that the electron donating axial ligands tend to depress the reduction potential while electron withdrawing axial ligands (fluorinated ligands) raise the reduction potentials of the alkylcobalamins. The electronic structure calculations imply that the computed reduction potentials of alkylcobalamins are directly correlated with the energies of their lowest unoccupied molecular orbitals (ELUMO values). Thus it is concluded that the ELUMO values of alkylcobalamins that depend upon the electronic nature of the upper axial ligands serve as the key descriptors of their reduction potentials. © 2012 Wiley Periodicals, Inc.
Interactions between 1‐butyl‐3‐methylimidazolium tetrafluoroborate ionic liquid and γ‐Al2O3(100) surface calculated by density functional theory
Authors: Martins Mateus J. F. , Ferreira Ary R. , Konstantinova Elena , de Abreu Heitor A. , Souza Wladmir F. , Chiaro Sandra S. X. , Dias Luís G. , Leitão Alexandre A. 
Published: May 2012

AbstractThe main aim of this work is to investigate the 1‐butyl‐3‐methylimidazolium tetrafluoroborate ([C4C1Im]+[BF4]−) ionic liquid (IL) adsorption on the γ‐Al2O3(100) by density functional theory calculations to try to rationalize the adsorption as an electrostatic phenomenon. Optimized geometries and interaction energies of IL one‐monolayer on the γ‐Al2O3were obtained on high surface coverage (one cation–anion pair per 94.96 nm2). A study of dispersion force was made to estimate its contribution to the adsorption. Overall, the process is ruled by electrostatic interaction between ions and surface. Adsorption of the anion [BF4]−and cation [C4C1Im]+was also studied by Bader charge analysis and charge density difference for supported and unsupported situations. It is suggested that the IL ions have their charges maintained with significant anion cloud polarization inward to the acid aluminum sites. © 2012 Wiley Periodicals, Inc.
Asymptotic behaviour at a tip of a rigid line inclusion in linearized elasticity
Authors: Itou H. , Khludnev A.M. , Rudoy E.M. , Tani A. 
Published: May 2012

AbstractWe consider an asymptotic behaviour of a solution near a tip of a rigid line inclusion in two dimensional homogeneous isotropic linearized elasticity. By means of Goursat‐Kolosov‐Muskhelishvili stress functions we derive convergent expansions of the solution around there. Furthermore, we give expressions of the invariant integral and the Irwin's formula.
A higher‐order finite element approach to the Kuramoto‐Sivashinsky equation
Authors: Anders D. , Dittmann M. , Weinberg K. 
Published: May 2012

AbstractThe Kuramoto‐Sivashinsky equation has emerged as a fundamental evolution equation to describe highly nonlinear physical processes in unstable systems. In general, it constitutes a nonlinear initial‐valued problem involving fourth‐order spatial derivatives. Finite element solutions for the Kuramoto‐Sivashinsky equation are not common because the primal variational formulation of fourth‐order operators requires finite element basis functions which are piecewise smooth and globally at least C1‐continuous. In this paper a novel B‐spline based finite element approach to the solution of the one‐dimensional Kuramoto‐Sivashinsky equation is presented. Extensive numerical studies of different scenarios in the Kuramoto‐Sivashinsky equation will illustrate the quality of our approach.
A biomimetic domino reaction for the concise synthesis of capreomycidine and epicapreomycidine
Authors: Büschleb Martin , Granitzka Markus , Stalke Dietmar , Ducho Christian 
Published: May 2012

Abstract
The non-proteinogenic amino acids capreomycidine and epicapreomycidine are constituents of antibiotically active natural products, but the synthesis of these unusual cyclic guanidine derivatives is challenging. The biosynthesis of capreomycidine has therefore been employed as a guideline to develop a concise biomimetic synthesis of both epimeric amino acids. The resulting domino-guanidinylation-aza-Michael-addition reaction provides the most convenient access to these amino acids in racemic form. Attempts to dissect the domino reaction into two separate transformations for a stereocontrolled version of this synthetic approach have also been made. The synthesized didehydro-arginine derivatives with urethane-protected guanidine moieties did not undergo the aza-Michael-addition anymore. These results may have wider implications for the 1,4-addition of guanidines to α,β-unsaturated carbonyl compounds, particularly to didehydro amino acids.