bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal rainfall threshold for monsoon rice production in India varies across space and time
Authors: Maiti Arabinda , Hasan Md Kamrul , Sannigrahi Srikanta , Bar Somnath , Chakraborti Suman , Mahto Shanti Shwarup , Chatterjee Sumanta , Pramanik Suvamoy , Pilla Francesco , Auerbach Jeremy , Sonnentag Oliver , Song Conghe , Zhang Qi 
Published: June 2024

AbstractClimate change affects Indian agriculture, which depends heavily on the spatiotemporal distribution of monsoon rainfall. Despite the nonlinear relationship between crop yield and rainfall, little is known about the optimal rainfall threshold, particularly for monsoon rice. Here, we investigate the responses of rice yield to monsoon rainfall in India by analyzing historical rice production statistics and climate data from 1990 to 2017. Results show that excessive and deficit rainfall reduces rice yield by 33.7% and 19%, respectively. The overall optimal rainfall threshold nationwide is 1621 ± 34 mm beyond which rice yield declines by 6.4 kg per hectare per 100 mm of rainfall, while the identifiable thresholds vary spatially across 14 states. The temporal variations in rice yield are influenced by rainfall anomalies featured by El Niño-Southern Oscillation events.
Perceptions of the determinants of health across income and urbanicity levels in eight countries
Authors: Abdalla Salma M. , Assefa Ethan , Rosenberg Samuel B. , Hernandez Mark , Koya Shaffi Fazaludeen , Galea Sandro 
Published: June 2024

Abstract
Background
A clear understanding of public perceptions of the social determinants of health remains lacking. This paper aimed to describe the relationship between income and urbanicity levels and public views of the determinants of health in eight middle-and high-income countries that varied across multiple characteristics.

Methods
We conducted a cross-sectional online survey in Brazil, China, Germany, Egypt, India, Indonesia, Nigeria, and the United States. Respondents were asked to select what they considered to be most important for health out of a list of ten determinants. We stratified the results by income and urbanicity levels and tested significance of differences between groups using two-tailed χ2 tests. Multivariable logistic regression models tested associations between demographic factors and the likelihood of respondents selecting the genetics, healthcare, income and wealth, or social support determinants.

Results
Here we show 8753 respondents across eight countries. Rankings of determinants are similar across income groups, except for two determinants. Respondents in the highest income group rank genetics in higher proportions (32.4%, 95%CI: 29.0%,35.8%) compared to other income groups. Conversely, those in lowest income group rank social support more frequently (27.9%, 95%CI: 25.3%,30.7%) than other income groups.
Those living in urban settings rank healthcare in higher proportions (61.2%, 95%CI: 59.0%,63.4%) compared to non-urban respondents; meanwhile, higher proportions (26.6%, 95%CI: 24.9%,28.3%) of non-urban respondents rank social support as important for health compared to urban respondents.

Conclusion
Demographic factors play a role in shaping public views of what affects health. Advancing public understanding about determinants of health requires tailoring public health messaging to account for socioeconomic position within a population.
Mendelian randomization reveals interactions of the blood proteome and immunome in mitral valve prolapse
Authors: Minvielle Moncla Louis-Hippolyte , Briend Mewen , Sokhna Sylla Mame , Mathieu Samuel , Rufiange Anne , Bossé Yohan , Mathieu Patrick 
Published: June 2024

Abstract
Background
Mitral valve prolapse (MVP) is a common heart disorder characterized by an excessive production of proteoglycans and extracellular matrix in mitral valve leaflets. Large-scale genome-wide association study (GWAS) underlined that MVP is heritable. The molecular underpinnings of the disease remain largely unknown.

Methods
We interrogated cross-modality data totaling more than 500,000 subjects including GWAS, 4809 molecules of the blood proteome, and genome-wide expression of mitral valves to identify candidate drivers of MVP. Data were investigated through Mendelian randomization, network analysis, ligand-receptor inference and digital cell quantification.

Results
In this study, Mendelian randomization identify that 33 blood proteins, enriched in networks for immunity, are associated with the risk of MVP. MVP- associated blood proteins are enriched in ligands for which their cognate receptors are differentially expressed in mitral valve leaflets during MVP and enriched in cardiac endothelial cells and macrophages. MVP-associated blood proteins are involved in the renewal-polarization of macrophages and regulation of adaptive immune response. Cytokine activity profiling and digital cell quantification show in MVP a shift toward cytokine signature promoting M2 macrophage polarization. Assessment of druggability identify CSF1R, CX3CR1, CCR6, IL33, MMP8, ENPEP and angiotensin receptors as actionable targets in MVP.

Conclusions
Hence, integrative analysis identifies networks of candidate molecules and cells involved in immune control and remodeling of the extracellular matrix, which drive the risk of MVP.
Decoding Age-Linked Masseter Vestibular Evoked Myogenic Potential Changes in Healthy, Aging Individuals
Authors: Ramesh Karan , Thirunavukkarasu Kumaran 
Published: June 2024

Purpose:
The primary objective of this study was to assess how age influences masseter vestibular evoked myogenic potential (mVEMP) parameters by utilizing 500-Hz tone burst stimuli delivered through air conduction.

Method:
The study involved 110 participants ranging from 15 to 60 years of age, grouped into five categories, all of whom had no previous issues related to their vestibular system. The participants were exposed to 500-Hz tone burst stimuli at 125 dB SPL through ER-3A inserts. These stimuli were presented to one ear at a time, with alternating polarity. A Tukey's honestly significant difference test was conducted to compare rectified and unrectified amplitude, along with latencies (P11 and N21) and the asymmetric ratio across all age groups. Additionally, a multivariate analysis of variance was performed to assess the impact of sex on the study variables.

Results:

All 110 participants (220 ears) in the study provided mVEMP responses, encompassing 100% of the subjects. The results revealed a significant reduction in both amplitude and latency extension for the P11 and N21 peaks. Interestingly, P11 latency was also prolonged in the youngest participants (Group 1), suggesting ongoing maturation of the system even beyond the age of 16 years. Moreover, a significant sex difference was observed in the P11 latencies. However, there were no substantial sex differences (
p
> .05) in N1 peak latency, peak-to-peak amplitude, rectified amplitude, and asymmetric ratio.

Conclusions:
Changes in structure occur due to degeneration, and the quantity of vestibular sensory hair cells gradually diminishes with age. The rate of decline is faster in semicircular canals compared to end organs, as observed by Merchant et al. (2000). Following a linear degeneration starting at the age of 40 years, a continuous reduction in sensory cells and primary neurons takes place until approximately 40% of vestibular sensory cells are lost by the age of 75 years and insufficient maturation can lead to prolonged peaks and reduced amplitudes compared with those that are considered normal. Therefore, it is crucial to consider the age of the participants when making diagnoses and incorporate relevant correction factors based on age-related reference data.
A fault‐tolerant and scalable boosting method over vertically partitioned data
Authors: Jiang Hai , Shang Songtao , Liu Peng , Yi Tong 
Published: June 2024

AbstractVertical federated learning (VFL) can learn a common machine learning model over vertically partitioned datasets. However, VFL are faced with these thorny problems: (1) both the training and prediction are very vulnerable to stragglers; (2) most VFL methods can only support a specific machine learning model. Suppose that VFL incorporates the features of centralised learning, then the above issues can be alleviated. With that in mind, this paper proposes a new VFL scheme, called FedBoost, which makes private parties upload the compressed partial order relations to the honest but curious server before training and prediction. The server can build a machine learning model and predict samples on the union of coded data. The theoretical analysis indicates that the absence of any private party will not affect the training and prediction as long as a round of communication is achieved. Our scheme can support canonical tree‐based models such as Tree Boosting methods and Random Forests. The experimental results also demonstrate the availability of our scheme.
Die Auswirkungen von sporttherapeutischen Leistungen auf die Fatigue
und Fatigability bei Personen mit Multipler Sklerose – eine systematische
Übersichtsarbeit
Authors: Wiesenberg Tamara 
Published: June 2024

Zusammenfassung
Einleitung Fatigue und Fatigability zählen mit 65% zu den häufigsten
belastenden Symptomen bei Multipler Sklerose (MS).
Ziel Ziel dieser Übersichtsarbeit war es zu schauen, welche
sporttherapeutischen Therapieinterventionen, unterteilt in Ausdauer-, Kraft- und
Wassertraining, zu einer Reduktion der Fatigue bzw. Fatigability bei Personen
mit Multipler Sklerose führen und welcher Ansatz bewährt ist.
Methode Die Literaturrecherche wurde auf den Datenbänken CENTRAL, PubMed
und PEDRO durchgeführt. Es wurde nach randomisiert kontrollierten Studien
gesucht, die eine sporttherapeutischen Trainingsintervention mit einer anderen
Intervention bei Personen mit Multipler Sklerose untersucht haben. Primäre
Zielparameter waren MFIS, FSS, FSMC, FKS und WEIMuS sowie der 6-MWT, 10-MWT und
der Sit-to-Stand-Test.
Ergebnisse Es wurden 38 randomisiert kontrollierte Studien mit 2366
Probanden in die Untersuchung eingeschlossen. Die verschiedenen
Interventionsmöglichkeiten wurden in die 5 Subgruppen „Ausdauertraining“,
„Krafttraining“, „Kraft- und Ausdauertraining“, „Wassertherapie“ und
„Robotergestützte Therapie“ eingeteilt. Es konnten in allen Bereichen
signifikante Gruppenunterschiede zugunsten der Interventionsgruppe für eine oder
mehrere primäre Zielparameter gemessen werden.
Fazit Es kann keine eindeutige Empfehlung für eine bestimmte
spottherapeutische Therapieintervention zur Verbesserung der Fatigue
ausgesprochen werden. Bei allen Interventionen wird eine Reduktion der Fatigue
erzielt.
Comprehensive analysis of adverse events associated with transmural use of LAMS in patients with liver cirrhosis: International multicenter study
Authors: Nimri Faisal , Ichkhanian Yervant , Shinn Brianna , Kowalski Thomas E. , Loren David E. , Kumar Anand , Schlachterman Alexander , Tantau Alina , Arevalo Martha , Taha Ashraf , Shamaa Omar , Viales Maria Chavarria , Khashab Mouen A. , Simmer Stephen , Singla Sumit , Piraka Cyrus , Zuchelli Tobias E. 
Published: June 2024

Abstract
Background and study aims Endoscopic ultrasound (EUS)-guided transmural (TM) deployment of lumen-apposing metal stents (LAMS) is considered relatively safe in non-cirrhotic patients and is cautiously offered to cirrhotic patients.
Patients and methods This was a retrospective, multicenter, international matched case-control study to study the safety of EUS-guided TM deployment of LAMS in cirrhotic patients.
Results Forty-three cirrhotic patients with model for end-stage liver disease score 12.5 ± 5, with 23 having ascites and 16 with varices underwent EUS-guided TM LAMS deployment, including 19 for pancreatic fluid collection (PFC) drainage, 13 gallbladder drainage, six for endoscopic ultrasound-directed transgastric endoscopic retrograde cholangiopancreatography (ERCP), three for EDGI, one for endoscopic ultrasound-directed transenteric ERCP, and one postsurgical collection drainage. Technical failure occurred in one LAMS for PFC drainage. Clinical failure was encountered in another PFC. Nine adverse events (AEs) occurred. The most common AE was LAMS migration (3), followed by non-bleeding mucosal erosion (2), delayed bleeding (2), sepsis (1), and anesthesia-related complication (pulseless electrical activity) (1). Most AEs were graded as mild (6), followed by severe (2), and moderate (1); the majority were managed conservatively. On univariable comparison, risk of AE was higher when using a 20 × 10 mm LAMS and the absence of through-the-LAMS plastic stent(s). Conditional logistic regression of matched case-control patients did not show any association between potential predicting factors and occurrence of AEs.
Conclusions Our study demonstrated that mainly in patients with Child-Pugh scores A and B cirrhosis and despite the presence of mild-to-moderate ascites in over half of cases, the majority of AEs were mild and could be managed conservatively. Further studies are warranted to verify the safety of LAMS in cirrhotic patients.
Preparing Future Pediatric Care Providers with a Clinical Informatics Elective
Authors: Rungvivatjarus Tiranun , Bialostozky Mario , Chong Amy Z. , Huang Jeannie S. , Kuelbs Cynthia L. 
Published: June 2024

Abstract
Background Clinical informatics (CI) has reshaped how medical information is shared, evaluated, and utilized in health care delivery. The widespread integration of electronic health records (EHRs) mandates proficiency among physicians and practitioners, yet medical trainees face a scarcity of opportunities for CI education.
Objectives We developed a CI rotation at a tertiary pediatric care center to teach categorical pediatric, pediatric–neurology, and medicine–pediatric residents foundational CI knowledge and applicable EHR skills.
Methods Created in 2017 and redesigned in 2020, a CI rotation aimed to provide foundational CI knowledge, promote longitudinal learning, and encourage real-world application of CI skills/tools. Led by a team of five physician informaticist faculty, the curriculum offers personalized rotation schedules and individual sessions with faculty for each trainee. Trainees were tasked with completing an informatics project, knowledge assessment, and self-efficacy perception survey before and after rotation. Paired t-test analyses were used to compare pre- and postcurriculum perception survey.
Results Thirty-one residents have completed the elective with their projects contributing to diverse areas such as medical education, division-specific initiatives, documentation improvement, regulatory compliance, and operating plan goals. The mean knowledge assessment percentage score increased from 77% (11.6) to 92% (10.6; p ≤ 0.05). Residents' perception surveys demonstrated improved understanding and confidence across various informatics concepts and tools (p ≤ 0.05).
Conclusion Medical trainees are increasingly interested in CI education and find it valuable. Our medical education curriculum was successful at increasing residents' understanding, self-efficacy, and confidence in utilizing CI concepts and EHR tools. Future data are needed to assess the impact such curricula have on graduates' proficiency and efficiency in the use of CI tools in the clinical workplace.
Versatility of the Keystone Design Perforator Island Flaps in Resurfacing Soft Tissue Defects
Authors: Sahu Ranjit Kumar , Mahadik Kaushik , Giri Sanjay Kumar , Suba Santanu , Mallik Mainak , Panda Ritesh , Kanungo Aparna , Minz Reena , Rout Sunil Kumar 
Published: June 2024

Abstract
Background The keystone design perforator island flap (KDPIF) is unique among local flaps because of its high potential for adaptation. We describe our experience with the use of the keystone flap for the reconstruction of a variety of defects in different regions of the body concerning its versatility, surgical outcomes, complications, postoperative pain, operative time, and esthetic outcomes.
Methods A prospective observational study was conducted at our institute from June 2021 to June 2023 where the use of KDPIFs in resurfacing soft tissue defects of different etiopathogenesis was evaluated and the data were analyzed.
Results Forty-four patients were included in the study with soft tissue defects of various etiologies and at different locations. The largest flap raised was 18 × 10 cm and the smallest was 4 × 2 cm. The average intraoperative time for completion of the procedure was 74.86 minutes (range: 45–120 minutes). The success rate of flap survivability was 95.45% with two patients having total flap loss necessitating another reconstructive option. Partial flap dehiscence which healed secondarily was observed in two patients. Postoperative pain showed a significant fall of 83.7% from baseline and 82.9% of cases were extremely satisfied with the esthetic outcome.
Conclusion The keystone flap is a valuable reconstructive tool in the armamentarium of a plastic surgeon. It is technically reproducible, suitable to be done in resource-limited settings, and provides contiguous tissue with good vascularity and fewer complications.
The Association between Anthropometric Indicators and Colorectal Polyps and Diverticulosis
Authors: Najafi Mobaraki Sahar , Joukar Farahnaz , Maroufizadeh Saman , Baghaee Massood , Asgharnezhad Mehrnaz , Mansour-Ghanaei Fariborz 
Published: June 2024

Abstract
Introduction Colonic polyps and diverticulosis are common colon findings on colonoscopy. One of the risk factors of colorectal polyps and diverticulosis is the anthropometric index. Therefore, we aimed to investigate the association between the anthropometric index and colorectal findings.
Methods In this cross-sectional study, we included 536 patients referred to Razi Hospital, Rasht, Iran, in 2023 for colonoscopy evaluation. Demographical data, clinical characteristics, and colonoscopy findings were recorded for further analysis. All data were analyzed using SPSS.16 by considering a significant level < 0.05
Results The results showed that 35.4% of the patients had polyps, with the majority having a single polyp. The patient's mean age was 55.94 ± 13.33 years; most were females (54.1%). The most common type of polyp was pedunculated, and most were located in the sigmoid colon. The prevalence of diverticular was 11.4%, most of which were also located in the sigmoid colon. Obesity was significantly associated with an increased risk of polyps, while overweight individuals had a higher risk of diverticula (P < 0.05). Age, rural residence, and low physical activity level were identified as factors associated with an increased risk of polyps and diverticula.
Conclusion The findings suggest that obesity and overweight are risk factors for polyps and diverticula, respectively. Further research is warranted to explore additional factors and develop preventive strategies for colorectal diseases. These results support the need for preventive strategies and screening programs to reduce the risk of future colorectal lesions.
Constipation in Women with High-Grade Intraepithelial Neoplasia and Cervical Cancer: Does the Extent of Cervical Lesion Invasion Influence the Severity of Constipation and Compromise Quality of Life?
Authors: Abreu Glicia Estevam de , Palácio Gabriel Perez , Silva Eduarda Alvarez , Braga Antônio Vítor Martinelli , Silva Paulo André Lago 
Published: June 2024

Abstract
Introduction Constipation is a common clinical condition, particularly among cancer patients.
Objective To assess the prevalence and severity of CF in women with high-grade intraepithelial neoplasia (HSIL) and cervical cancer (CC), as well as the impact of this condition on their daily lives.
Methods A cross-sectional study was conducted at a tertiary cancer center. To assess the presence and severity of constipation, the Rome IV criteria, and the Constipation Scoring System (CSS) were used. To assess the impact of constipation on daily life, the Visual Analogue Scale (VAS) was used.
Results The study included 153 patients with HSIL or CC, with a median age of 44 (IQR 35–56) years. Constipation was reported in 54 (35.3%) patients, 33 (61.1%) of those with HSIL, and 21 (38.9%) of those with CC. In constipated patients, the median number of positive Rome IV criteria items was 3 (IQR 2–5). "Irregular or hard stools" was the most common complaint, affecting 41 (75.9%) of the patients. In patients with CC, the use of analgesic medications was associated with constipation (p = 0.016). There is no link between constipation and invasive cancer (p = 0.492). Constipation had a daily impact of 7.5 (IQR 4.75–9), with no relationship between VAS and clinical diagnosis (HSIL or CC) [7 (IQR 3-9) X 8 (5-9.5), p-value = 0.536] The more severe the constipation, the more disturbing it is to these women's daily lives.
Conclusion Constipation is common in women with cervical lesions, affecting their daily lives regardless of their severity.
Evaluation of Hepatic Shear Wave Elastography to Assess Liver Fibrosis in Biliary Atresia Patients and Its Correlation with Liver Histology and Surgical Outcomes: A Prospective Observational Study
Authors: Ahmad Md Fahim , Solanki Shailesh , Kanojia Ravi Prakash , Bhatia Anmol , Lal Sadhna B. , Saxena Akshay K. , Gupta Kirti 
Published: June 2024

Abstract
Introduction The native liver survival in biliary atresia (BA) depends on various factors, and one of the crucial factors is the rate of progression of liver fibrosis after portoenterostomy, but there is no reliable investigation to assess it. This study evaluated shear wave elastography (SWE) to detect liver fibrosis in BA patients and assess its utility during follow-up.
Materials and Methods This was an observational study; SWE was done preoperatively and postoperatively at 3 and 6 months. The SWE values were analyzed to determine their correlations with preoperative liver histology as well as with postoperative SWE variation between different postoperative outcomes.
Results Twenty-one patients were included in the study; the preoperative SWE values were strongly correlated with liver biopsy grading (p < 0.001). At the 3 months postoperatively, SWE was done for 18 children: 12 in group A (patent bilioenteric drainage on hepatobiliary iminodiacetic acid scan) and 6 (nonpatent) in group B; mean SWE value was 12.8 and 17.3 kPa, respectively (p < 0.001). Ten children from group A underwent SWE 6 months postoperatively, and the mean value was 13.23 kPa.
Conclusion The SWE values correlate with liver histology grading, suggesting a reliable alternative to biopsy. Additionally, the baseline SWE values and their trend during follow-up can provide information on the disease's progression.