bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlates of identity statuses among Chinese adolescents in Hong Kong
Authors: Lam Rebecca S.Y. , Tam Vicky C.W. 
Published: March 2011

Abstract
This study investigates correlates of Hong Kong Chinese adolescents’ identity statuses with (i) parental and school contexts and (ii) major psychosocial developmental outcomes. Data were collected from 1260 Secondary 2–4 (equivalent to Grades 8–10 in the US school system) students through a questionnaire survey. Results of hierarchical regression analysis indicated that parental attributes of acceptance, values and goals, and psychological control, and school contextual factor of task orientations predicted identity achievement, whereas parents’ acceptance, psychological and firm control, and teacher's support predicted identity foreclosure. Regarding the impact on psychosocial development, another series of regression analyses revealed that (i) identity achievement predicted low depression, high self-esteem, and high self-efficacy; (ii) moratorium predicted low self-esteem; and (iii) foreclosure predicted high self-efficacy. Overall, the findings shed light on adolescent identity development in Hong Kong, facilitating discussions on identity-related issues.
Zur Bedeutung von λΟΓΟC im Prolog des Judasevangeliums
Authors: Förster Hans 
Published: March 2011

ABSTRACT
The translation of the first lines of the Gospel of Judas has been the subject of scholarly debate. One of the major problems seems to be the meaning of the Greek word λΟΓΟC in Coptic context. This article, after presenting the debate, proposes a new translation of this passage, which takes into consideration the meaning of the word λΟΓΟC in other Coptic texts.
The Chronographiae of Julius Africanus and its Jewish Antecedents
Authors: Adler William 
Published: March 2011

ZUSAMMENFASSUNG
In der Forschung ist die Meinung verbreitet, dass Julius Africanus in seinen Chronographiae einfach geläufi ge Topoi der jüdischen (und christlichen) Tradition zu einer vollständigen Chronik ausgeweitet hat. Verf. analysiert die Art und Weise, wie Julius Africanus ältere jüdische Quellen und Traditionen benutzt hat, und berücksichtigt dabei die verschiedenen Bereiche des benutzten Quellenmaterials: mündliche Überlieferung palästinischer Provenienz, biblische Exegese, Historiographie, apokryphe Literatur (besonders das Jubiläenbuch und das äthiopische Henochbuch), Apologetik und apokalyptische Endzeitspekulation. Es zeigt sich, dass Julius Africanus dieses facettenreiche Quellenmaterial an die Erfordernisse der hellenistischen Universalchronik angepasst und so aus dem von ihm benutzten Material etwas ganz Eigenständiges geschaffen hat.
Susanna, the Fathers and the Passio Sereni (BHL 7595-6): Sexual Morals, Intertextuality and Early Christian Self-Definition
Authors: Praet Danny 
Published: March 2011

ZUSAMMENFASSUNG
Die Passio Sereni (BHL 7595-6) ist ein einzigartiger Fall von Intertextualität in der Hagiographie der Spätantike. Dieser Aufsatz will zeigen, dass die passio nicht historisch-authentisch ist, sondern eine reine literarische Konstruktion: ihre Erzählstruktur ist mit der alttestamentlichen Geschichte von Susanna und den zwei Ältesten fast identisch. Der frühchristliche Autor hat aber diese Daniel-Geschichte in einen Konflikt zwischen Heiden und Christen umgewandelt und auch die Rollen von Susanna und den Ältesten geschlechtlich und moralisch vertauscht. Eine heidnische Frau, die in einem Garten ein ehebrecherisches Rendezvous hatte, wird von einem alten christlichen Mann, Serenus, beobachtet. Die Pläne der Frau werden vereitelt, woraufhin die Frau ein falsches Zeugnis gegen Serenus ablegt. Eine Analyse des ursprünglichen Daniel-Apokryphons, ein Überblick über die Rezeption der passio in der Patristik und ein Vergleich mit dem alten römischen Ideal der pudicitia führen zu der Schlussfolgerung, dass die Passio Sereni (vermutlich etwa 400 n.Chr.) geschrieben wurde, um ein asketisches Christentum zu fördern als das einzig wahre Erbe der jüdischen und der römischen Tradition.
Thyroid hormone status within the physiological range affects bone mass and density in healthy men at the age of peak bone mass
Authors: Roef Greet , Lapauw Bruno , Goemaere Stefan , Zmierczak Hans , Fiers Tom , Kaufman Jean-Marc , Taes Youri 
Published: March 2011

ContextThe hormonal factors involved in the regulation of peak bone mass (PBM) in men have not been fully investigated. Apart from gonadal steroids and somatotropic hormones, thyroid hormones are known to affect bone maturation and homeostasis and are additional candidate determinants of adult bone mass.ObjectiveWe aimed to investigate between-subject physiological variation in free and total thyroid hormone concentrations, TSH, and thyroid binding globulin (TBG) in relation to parameters of bone mass, geometry, and mineral density in healthy men at the age of PBM.Design and settingWe recruited 677 healthy male siblings aged 25–45 years in a cross-sectional, population-based study. Areal and volumetric bone parameters were determined using dual-energy x-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT). Total and free thyroid hormones, TBG, and TSH were determined using immunoassays.ResultsFree and total thyroid hormone concentrations were inversely associated with bone mineral density (BMD) and bone mineral content (BMC) at the hip and total body (free triiodothyronine (FT3), total T3 (TT3), and total T4 (TT4)) and at the spine (FT3). TBG was negatively associated with BMC and areal BMD at all sites. At the radius, cortical bone area was inversely associated with TT3, TT4, and TBG, and trabecular bone density was inversely associated with free thyroxine, TT4, and TBG. We observed inverse associations between cortical bone area at the mid-tibia and FT3, TT3, TT4, and TBG. No associations between TSH and DXA or pQCT measurements were found.ConclusionIn healthy men at the age of PBM, between-subject variation in thyroid hormone concentrations affects bone density, with higher levels of FT3, TT3, TT4, and TBG being associated with less favorable bone density and content.
Bayesian Multiple Quantitative Trait Loci Mapping for Recombinant Inbred Intercrosses
Authors: Yuan Zhongshang , Zou Fei , Liu Yanyan 
Published: March 2011

AbstractThe Collaborative Cross (CC) is a renewable mouse resource that mimics the genetic diversity in humans. The recombinant inbred intercrosses (RIX) generated from CC recombinant inbred (RI) lines share similar genetic structures to those of F2 individuals. In contrast to F2 mice, genotypes of RIX can be inferred from the genotypes of their RI parents and can be produced repeatedly. Also, RIX mice do not typically share the same degree of relatedness. This unbalanced genetic relatedness requires careful statistical modeling to avoid a large number of false positive findings. For complex traits, mapping multiple genes simultaneously is arguably more powerful than mapping one gene at a time. In this article, we describe how we have developed a Bayesian quantitative trait locus (QTL) mapping method that simultaneously deals with the special genetic architecture of RIX and maps multiple genes. The performance of the proposed method is evaluated by extensive simulations. In addition, for a given set of RI lines, there are numerous ways to generate RIX samples. To provide a general guideline on future RIX studies, we compare several RIX designs through simulations.
Effect of Helicobacter pylori Eradication Therapy on Risk of Hospitalization for a Major Ulcer Event
Authors: Hsiao Fei‐Yuan , Tsai Yi‐Wen , Wen Yu‐Wen , Kuo Ken N. , Tsai Chia‐Rung , Huang Weng‐Foung 
Published: March 2011

Study Objective. To compare Helicobacter pylori eradication therapy with antisecretory therapy aloneonthe riskofhospitalization for a major ulcer event.Design. Retrospective, population‐based cohort study.Data Source. The 2000–2006 National Health Insurance database in Taiwan.Patients. A total of 838,176 patients diagnosed with a gastrointestinal ulcer and who filled at least one prescription for antiulcer therapy, either H. pylori eradication therapy (331,364 patients [39.53%])orantisecretory therapy alone (506,812 patients [60.47%]), between January1, 2001, and December 31, 2006.Measurements and Main Results. The primary outcome was hospitalization for a major ulcer event, defined as a gastrointestinal ulcer with hemorrhage and/or perforation. Cox proportional hazards models, adjusted for demographic and clinical characteristics, were used to compare the risk of hospitalization for a major ulcer event between the group receiving H. pylori eradication therapy (triple or quadruple combination therapy that includes an antisecretory agent) and the group receiving antisecretory therapy alone (histamine2‐receptor blocker or proton pump inhibitor). The H. pylori eradication therapy group was divided into initial users (combination therapy received immediately after gastrointestinal ulcer diagnosis) and late users (combination therapy received after antisecretory therapy with time lag≤180 days, 181–365 days, or>365 days from ulcer diagnosis). A secondary analysis was conductedinthe three late H. pylorieradication therapy subgroups to determine if risk of hospitalization for major ulcer events differed by timing of receipt of therapy. Compared with the antisecretory therapy alone group, the H. pylori therapy group (initial users) had a significantly decreased risk of hospitalization for major ulcer events (adjusted hazard ratio [AHR] 0.57, 95% confidence interval [CI] 0.54–0.59, p<0.001). However, later use of H. pylori therapy was associated with a higher riskofhospitalization for major ulcer events (time lag 181–365 days, AHR 1.68, 95%CI1.51–1.86, p<0.001;>365 days, AHR 1.74, 95% CI1.67–1.80, p<0.001) compared with those who received H. pylori therapy within6months(≤180 days) after gastrointestinal ulcers were diagnosed.Conclusion. Helicobacter pyloritherapy given within 6 months of a diagnosis of gastrointestinal ulcer was associated with a reduced risk of hospitalization for major ulcer events. Our findings extend the evidence from clinical trials that report the value ofH. pylori eradication therapy in reducing ulcer recurrence by documenting the real‐world benefit of reducing the risk of hospitalization for major gastrointestinal ulcer events.
A Preclinical and Clinical Study of Lithium in Low-Grade Neuroendocrine Tumors
Authors: Lubner Sam J. , Kunnimalaiyaan Muthusamy , Holen Kyle D. , Ning Li , Ndiaye Mary , LoConte Noelle K. , Mulkerin Daniel L. , Schelman William R. , Chen Herbert 
Published: March 2011

Abstract

Background.
Low-grade neuroendocrine tumors (NETs) respond poorly to chemotherapy; effective, less toxic therapies are needed. Glycogen synthase kinase (GSK)-3β has been shown to regulate growth and hormone production in NETs. Use of lithium chloride in murine models suppressed carcinoid cell growth, reduced GSK-3β levels, and reduced expression of chromogranin A. This study assessed the efficacy of lithium chloride in patients with NETs.

Design.
Eligible patients had low-grade NETs. A single-arm, open-label phase II design was used. Lithium was dosed at 300 mg orally three times daily, titrated to serum levels of 0.8–1.0 mmol/L. The primary endpoint was objective tumor response by the Response Evaluation Criteria in Solid Tumors. Secondary endpoints included overall survival, progression-free survival, GSK-3β phosphorylation, and toxicity.

Results.
Fifteen patients were enrolled between October 3, 2007 and July 17, 2008, six men and nine women. The median age was 58 years. Patient diagnoses were carcinoid tumor for eight patients, islet cell tumor for five patients, and two unknown primary sites. Eastern Cooperative Oncology Group performance status scores were 0 or 1. Two patients came off study because of side effects. The median progression-free survival interval was 4.50 months. There were no radiographic responses. Because of an early stopping rule requiring at least one objective response in the first 13 evaluable patients, the study was closed to further accrual. Patients had pre- and post-therapy biopsies.

Conclusions.
Lithium chloride was ineffective at obtaining radiographic responses in our 13 patients who were treated as part of this study. Based on the pre- and post-treatment tumor biopsies, lithium did not potently inhibit GSK-3β at serum levels used to treat bipolar disorders.
Potential Strategies to Eliminate Built Environment Disparities for Disadvantaged and Vulnerable Communities
Authors: Hutch Daniel J. , Bouye Karen E. , Skillen Elizabeth , Lee Charles , Whitehead LaToria , Rashid Jamila R. 
Published: March 2011

In 2006, the Federal Collaboration on Health Disparities Research (FCHDR) identified the built environment as a priority for eliminating health disparities, and charged the Built Environment Workgroup with identifying ways to eliminate health disparities and improve health outcomes. Despite extensive research and the development of a new conceptual health factors framework, gaps in knowledge exist in areas such as disproportionate environmental and community hazards, individual and cumulative risks, and other factors. The FCHDR provides the structure and opportunity to mobilize and partner with built environment stakeholders, federal partners, and interest groups to develop tools, practices, and policies for translating and disseminating the best available science to reduce health disparities.
Factors Affecting Employment at Initiation of Dialysis
Authors: Muehrer Rebecca J. , Schatell Dori , Witten Beth , Gangnon Ronald , Becker Bryan N. , Hofmann R. Michael 
Published: March 2011

Summary

Background and objectives
Half the individuals who reach ESRD are working age (<65 years old) and many are at risk for job loss. Factors that contribute to job retention among working-age patients with chronic kidney disease before ESRD are unknown. The purpose of the study is to understand factors associated with maintaining employment among working-age patients with advanced kidney failure.

Design, setting, participants, & measurements
In this retrospective study we reviewed the United States Renal Data System database (1992 through 2003) and selected all patients (n = 102,104) who were working age and employed 6 months before dialysis initiation. Factors that were examined for an association with maintaining employment status included demographics, comorbid conditions, ESRD cause, insurance, predialysis erythropoietin use, and dialysis modality.

Results
Maintaining employment at the same level during the final 6 months before dialysis was more likely among (1) white men ages 30 to 49 years; (2) patients with either glomerulonephritis, cystic, or urologic causes of renal failure; (3) patients choosing peritoneal dialysis for their first treatment; (4) those with employer group or other health plans; and (5) erythropoietin usage before ESRD. Maintaining employment status was less likely among patients with congestive heart failure, cardiovascular disease, cancer, and other chronic illnesses.

Conclusions
The rate of unemployment in working-age patients with chronic kidney disease and ESRD is high compared with that of the general population. Treating anemia with erythropoietin before kidney failure and educating patients about work-friendly home dialysis options might improve job retention.
Longitudinal Association of Depressive Symptoms with Rapid Kidney Function Decline and Adverse Clinical Renal Disease Outcomes
Authors: Kop Willem J. , Seliger Stephen L. , Fink Jeffrey C. , Katz Ronit , Odden Michelle C. , Fried Linda F. , Rifkin Dena E. , Sarnak Mark J. , Gottdiener John S. 
Published: March 2011

Summary

Background and objectives
Depression is a risk indicator for adverse outcomes in dialysis patients, but its prognostic impact in individuals who are not yet on dialysis is unknown. This study examines whether depressive symptoms are longitudinally associated with renal function decline, new-onset chronic kidney disease (CKD), ESRD, or hospitalization with acute kidney injury (AKI).

Design, setting, participants, & measurements
Depressive symptoms were measured in a longitudinal cohort study with the 10-item Centers for Epidemiologic Studies Depression scale using a previously validated cut-off value (≥8). CKD at study entry and during follow-up was defined as an estimated GFR (eGFR) < 60 ml/min per m2. Outcomes were rapid decline in eGFR (>3 ml/min per m2 per year), new-onset CKD, ESRD (U.S. Renal Data System-based), and AKI (based on adjudicated medical record review). The median follow-up duration was 10.5 years.

Results
Depressed participants (21.2%) showed a higher prevalence of CKD at baseline compared with nondepressed participants in multivariable analysis. Depression was associated with a subsequent risk of rapid decline in eGFR, incident ESRD, and AKI, but not incident CKD in unadjusted models. In multivariable analyses, only associations of depressive symptoms with AKI remained significant.

Conclusions
Elevated depressive symptoms are associated with subsequent adverse renal disease outcomes. The depression-related elevated risk of AKI was independent of traditional renal disease risk factors and may in part be explained by the predictive value of depression for acute coronary syndromes and heart failure hospitalizations that can be complicated by AKI.
Survival in Pediatric Dialysis and Transplant Patients
Authors: Samuel Susan M. , Tonelli Marcello A. , Foster Bethany J. , Alexander R. Todd , Nettel-Aguirre Alberto , Soo Andrea , Hemmelgarn Brenda R. 
Published: March 2011

Summary

Background and objectives
Long-term follow-up data are few in children with ESRD. We sought to describe long-term survival, assess risk factors for death, and compare survival between two time periods in pediatric ESRD patients.

Design, setting, participants, & measurements
We used a population-based retrospective cohort utilizing data from a national organ failure registry and from Canada's universal healthcare system. We included 843 children (ages, 0 to 18) initiating renal replacement therapy from 1992 to 2007 and followed them until death or date of last contact (median follow-up, 6.8 years; interquartile range, 3.0 to 10.6). We assessed risk factors for death and examined cause-specific mortality.

Results
During 5991 patient-years of follow-up, 107 (12.7%) patients died. Unadjusted cumulative survival for the cohort was: 91.7% (95% CI, 89.8 to 93.7%) at 5 years and 85.8% (95% CI, 82.8 to 88.8%) at 10 years. Among patients commencing dialysis, overall adjusted survival was poorest among those who started dialysis at age <1 year. No secular trends in survival were noted for either dialysis or transplant patients. The proportion of incident patients receiving pre-emptive transplantation increased over time. Pre-emptively transplanted patients did not demonstrate superior adjusted survival compared with those who spent >2 years on dialysis before transplant (hazard ratio, 1.53; 95% CI, 0.63 to 3.67).

Conclusions
No significant improvements in survival were observed among ESRD patients over the study period. Time with transplant function had the strongest association with survival. Pre-emptive transplantation was not associated with improved survival in adjusted models.
Pharmacokinetics and Pharmacodynamics of Intravenous Daptomycin during Continuous Ambulatory Peritoneal Dialysis
Authors: Cardone Katie E. , Lodise Thomas P. , Patel Nimish , Hoy Christopher D. , Meola Shari , Manley Harold J. , Drusano George L. , Grabe Darren W. 
Published: March 2011

Summary

Background and objectives
This study sought to (1) characterize the pharmacokinetic (PK) profile of intravenous (IV) daptomycin among patients receiving continuous ambulatory peritoneal dialysis (CAPD); (2) identify optimal IV CAPD dosing schemes; and (3) determine extent of daptomycin penetration into the peritoneal space after IV administration.

Design, setting, participants, & measurements
A PK study was conducted among eight CAPD patients. Population PK modeling and Monte Carlo simulation (MCS) were used to identify CAPD dosing schemes providing efficacy and toxicity plasma profiles comparable with those obtained from MCS using the daptomycin population PK model derived from patients in the Staphylococcus aureus bacteremia-infective endocarditis (SAB-IE) study. The primary efficacy exposure target was the area under the curve (AUC). For toxicity, the goal was to identify CAPD dosing schemes that minimized plasma trough concentrations in excess of 24.3 mg/L. Finally, peritoneal cavity penetration was determined.

Results
Administration of IV daptomycin 4 or 6 mg/kg, depending on indication, every 48 h was identified as the optimal CAPD dosing scheme. This regimen provided cumulative (AUC0–48) and daily partitioned (AUC0–24h and AUC24–48h) plasma AUC values similar to the SAB-IE or “typical patient” simulations. In addition, the proportion of patients likely to experience an elevated trough concentration in excess of 24.3 mg/L was similar between every 48 h CAPD dosing and the referent group. Penetration into the peritoneal cavity was 6% of plasma.

Conclusions
Daptomycin 4 or 6 mg/kg, on the basis of indication, IV every 48 h was found to be the optimal IV CAPD dosing scheme.
p38 Mitogen-Activated Protein Kinase-Dependent Transactivation of ErbB Receptor Family
Authors: Hemi Rina , Yochananov Yafit , Barhod Ehud , Kasher-Meron Michal , Karasik Avraham , Tirosh Amir , Kanety Hannah 
Published: March 2011

OBJECTIVE
Stress stimuli such as tumor necrosis factor (TNF) have been shown to induce insulin receptor substrate (IRS)-1 serine phosphorylation and insulin resistance by transactivation of ErbB receptors. We aimed at elucidating the potential role of p38 mitogen-activated protein kinase (p38MAPK) in mediating stress-induced ErbB receptors activation.

RESEARCH DESIGN AND METHODS
p38MAPK effect on ErbBs transactivation and insulin signaling was assessed in Fao or HepG2 cells, exposed to stress stimuli, and on metabolic parameters in ob/ob and C57/BL6 mice.

RESULTS
High-fat diet–fed mice and ob/ob mice exhibited elevated hepatic p38MAPK activation associated with glucose intolerance and hyperinsulinemia. Liver expression of dominant-negative (DN)-p38MAPKα in ob/ob mice reduced fasting insulin levels and improved glucose tolerance, whereas C57/BL6 mice overexpressing wild-type p38MAPKα exhibited enhanced IRS-1 serine phosphorylation and reduced insulin-stimulated IRS-1 tyrosine phosphorylation. Fao or HepG2 cells exposed to TNF, anisomycin, or sphingomyelinase demonstrated rapid transactivation of ErbB receptors leading to PI3-kinase/Akt activation and IRS-1 serine phosphorylation. p38MAPK inhibition either by SB203580, by small interfering RNA, or by DN-p38MAPKα decreased ErbB receptors transactivation and IRS-1 serine phosphorylation and partially restored insulin-stimulated IRS-1 tyrosine phosphorylation. When cells were incubated with specific ErbB receptors antagonists or in cells lacking ErbB receptors, anisomycin- and TNF-induced IRS-1 serine phosphorylation was attenuated, despite intact p38MAPK activation. The stress-induced p38MAPK activation leading to ErbB receptors transactivation was associated with intracellular reactive oxygen species generation and was attenuated by treatment with antioxidants.

CONCLUSIONS
Hepatic p38MAPK is activated following various stress stimuli. This event is upstream to ErbB receptors transactivation and plays an important role in stress-induced IRS-1 serine phosphorylation and insulin resistance.
Threefolds with big and nef anticanonical bundles II
Authors: Jahnke Priska , Peternell Thomas , Radloff Ivo 
Published: March 2011

Abstract
In a follow-up to our paper [Threefolds with big and nef anticanonical bundles I, Math. Ann., 2005, 333(3), 569–631], we classify smooth complex projective threefolds Xwith −K
X big and nef but not ample, Picard number γ(X) = 2, and whose anticanonical map is small. We assume also that the Mori contraction of X and of its flop X
+ are not both birational.