bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Microwave Hydrothermal Synthesis and Photocatalytic Activity of AgIn5S8 for the Degradation of Dye.
Authors: Zhang Wenjuan , Li Danzhen , Sun Meng , Shao Yu , Chen Zhixin , Xiao Guangcan , Fu Xianzhi 
Published: December 2010

AbstractFor the first time AgIn5S8 powders are synthesized by a microwave hydrothermal method from an aqueous solution of Ag2SO4, InCl3, and an excess of thioacetamide (glass vessel, pH 4, microwaves, 80, 120, 160, or 200 °C, 10 min).
ChemInform Abstract: The First Quaternary Lanthanide(III) Nitride Iodides: NaLn4N2I7 (Ln: La—Nd).
Authors: Schurz Christian M. , Schleid Thomas 
Published: December 2010

AbstractSingle crystals of the title compounds are synthesized from the respective lanthanide metal Ln (Ln: La—Nd), LnI3, NaN3 in the molar ratio of 8:10:3, and an excess of NaI (silica ampule, 700 °C, 7 d).
ChemInform Abstract: New Ternary Rare‐Earth Metal Boride Carbides R15B4C14 (R: Y, Gd—Lu) Containing BC2 Units: Crystal and Electronic Structures, Magnetic Properties.
Authors: Babizhetskyy Volodymyr , Simon Arndt , Mattausch Hansjuergen , Hiebl Kurt , Zheng Chong 
Published: December 2010

AbstractThe title compounds are prepared by arc‐melting of stoichiometric mixtures of the elements followed by annealing (silica tubes, Ar, 1270 K, 1 month).
ChemInform Abstract: New Three‐Dimensional Inorganic Frameworks Based on the Uranophane‐Type Sheet in Monoamine Templated Uranyl‐Vanadates.
Authors: Jouffret Laurent , Shao Zhenmian , Rivenet Murielle , Abraham Francis 
Published: December 2010

AbstractThe structures of the new uranyl vanadates (III)—(IX) are determined by single crystal XRD.
ChemInform Abstract: Investigations of Enantioreversal in Both Direct and Directed Enantioselective Aldol Reactions Catalyzed by CuCl2[(‐)‐Sparteine] and NiCl2[(‐)‐Sparteine] Complexes.
Authors: Maheswaran H. , Joseph P. J. Amal , Prasanth K. Leon , Priyadarshink S. , Satyanarayana P. , Likhar Praveen R. , Kantam M. Lakshmi 
Published: December 2010

AbstractIn most cases a reversal in the enantioselectivity of the title reactions is observed changing the catalysts metal atom from copper to nickel.
ChemInform Abstract: New (S)‐Proline Derivatives as Catalysts for the Enantioselective Aldol Reaction.
Authors: Maleev V. I. , Gugkaeva Z. T. , Moskalenko M. A. , Tsaloev A. T. , Lyssenko K. A. 
Published: December 2010

AbstractNew (S)‐proline derivatives (I) are synthesized and tested as organocatalysts for the asymmetric aldol reaction of 4‐nitrobenzaldehyde with acetone.
ChemInform Abstract: The [2 + 2]‐Cycloaddition Reaction of Bisallenes: A Dramatic Substituent Effect.
Authors: Lu Ping , Ma Shengming 
Published: December 2010

AbstractBisallenes possessing a phenylsulfonyl or butyl substituent at the internal position of allene moieties are smoothly transformed to the corresponding bicyclo derivatives in moderate to very good yields with good regioselectivity.
ChemInform Abstract: Benzoyl Radicals from (Hetero)aromatic Aldehydes. Decatungstate Photocatalyzed Synthesis of Substituted Aromatic Ketones.
Authors: Ravelli Davide , Zema Michele , Mella Mariella , Fagnoni Maurizio , Albini Angelo 
Published: December 2010

AbstractBenzoyl radicals are generated directly from aromatic aldehydes upon tetrabutylammonium decatungstate photocatalysis under mild conditions.
ChemInform Abstract: Room‐Temperature Palladium(II)‐Catalyzed N‐Vinylation of Sulfonamides and Acylamides with Vinyl Acetate as Vinyl Source.
Authors: Xu Jun , Fu Yao , Xiao Bin , Gong Tianjun , Guo Qingxiang 
Published: December 2010

AbstractStudies are described for the synthesis of enamides.
ChemInform Abstract: Synthesis of Novel Carbohydrate‐Based Iminophosphinite Ligands in Pd‐Catalyzed Asymmetric Allylic Alkylations.
Authors: Shen Chao , Xia Haijun , Zheng Hui , Zhang Pengfei , Chen Xinzhi 
Published: December 2010

AbstractThe first application of carbohydrate‐based phosphinite—imine ligands in asymmetric allylic alkylation reactions is reported.
ChemInform Abstract: A General and Efficient Catalyst for Palladium‐Catalyzed C—O Coupling Reactions of Aryl Halides with Primary Alcohols.
Authors: Gowrisankar Saravanan , Sergeev Alexey G. , Anbarasan Pazhamalai , Spannenberg Anke , Neumann Helfried , Beller Matthias 
Published: December 2010

AbstractA novel, sterically hindered, air‐stable bispyrazolphosphine ligand accelerates the palladium‐catalyzed synthesis of alkyl aryl ethers such as (III) and (V) in moderate to excellent yields.
ChemInform Abstract: A General and Facile Approach for the Synthesis of 2′‐Functionalized 1,1′‐Binaphthyl‐2‐ols.
Authors: Xie Xiaomin , Ding Lina , Ni Gang , Zhang Zhaoguo , Gao Jinsheng 
Published: December 2010

AbstractA binaphthofuran‐derived, C,O‐dilithiated intermediate reacts with different nucleophiles to give the corresponding 2′‐functionalized 1,1′‐binaphthyl‐2‐ols.
ChemInform Abstract: Conversion of Conjugated Enones into Enantiomerically Pure β‐Hydroxy Ketones or 1,3‐Diols — Samarium(II) Bromide Reductions of Protected α,β‐Dihydroxy Ketones.
Authors: Zoerb Andreas , Brueckner Reinhard 
Published: December 2010

AbstractAsymmetric dihydroxylation of enones (I) provides access towards α,β‐dihydroxy ketones (II) in excellent enantioselectivity (up to <99% e.e.), which are either protected in situ as phenylboronates (IX) or in a separate step as acetonides (IV).
ChemInform Abstract: Intramolecular Polar Addition Reactions of Active Methylene Moieties to Aryl‐Substituted Alkenes via Photoinduced Electron Transfer.
Authors: Ohashi Maki , Nakatani Keisuke , Maeda Hajime , Mizuno Kazuhiko 
Published: December 2010

AbstractA novel construction of five‐ to seven‐membered cycloalkane derivatives can be achieved.
ChemInform Abstract: A Novel Efficient Method for Synthesis of Propargylamines via Three‐Component Coupling of Aryl Azide, Aldehyde, and Alkyne Promoted by Iron—Iodine—Copper(I) Bromide.
Authors: Zhang Kui , Huang You , Chen Ruyu 
Published: December 2010

AbstractThe new synthetic protocol allows the preparation of a broad spectrum of the synthetically important amine products.
ChemInform Abstract: A New Method for the Synthesis of Iminoquinones via DMP‐Mediated Oxidative Reaction.
Authors: Ma Hengchang , Wu Shang , Sun Qiangsheng , Li Hongyan , Chen Yannan , Zhao Wenqing , Ma Bihui , Guo Qing , Lei Ziqiang , Yan Jun 
Published: December 2010

AbstractThe reaction of anilines in the presence of the activator Bu4NBr results in formation of brominated products.
ChemInform Abstract: A Novel Catalytic Decarbonylative Heck‐Type Reaction and Conjugate Addition of Aldehydes to Unsaturated Carbonyl Compounds.
Authors: Yang Luo , Correia Camille A. , Guo Xiangyu , Li Chao‐Jun 
Published: December 2010

AbstractVarious aromatic aldehydes can be used in the process.
ChemInform Abstract: Triflic Salt‐Catalyzed Coupling: Iron Triflate‐Catalyzed Homocoupling of Aryl Bromides in the Presence of Metallic Magnesium.
Authors: Zhang Yan‐Yan , Lin Jing‐Du , Xu Xiao‐Liang , Li Jing‐Hua 
Published: December 2010

AbstractThe homocoupling proceeds smoothly as one‐pot reaction without formation of the corresponding Grignard reagent.
ChemInform Abstract: Solvent‐Free Microwave‐Assisted Multicomponent Reaction for Preparation of 2‐Amino‐1‐aryl‐2‐(cyclohex‐1‐enyl)ethanones as Precursors of Pseudoephedrine Analogues.
Authors: Ma Li‐Jian , Inokuchi Tsutomu 
Published: December 2010

AbstractMicrowave irradiation of chloroacetylarenes with enamines leads to an aza‐Darzens reaction followed by a rearrangement of the aziridinium intermediate, affording title compounds such as (III) and (V) in good yields.
ChemInform Abstract: A Room‐Temperature, Copper‐Catalyzed Cascade Process for Diethyl 2‐Aryl‐3,4‐dihydro‐4‐oxo‐1,1(2H)‐naphthalenedicarboxylate.
Authors: Li Zhengqiu , Fu Liangbin , Wei Jiajia , Ha Chengyong , Pei Duanqing , Cai Qian , Ding Ke 
Published: December 2010

AbstractThe procedure affords a broad spectrum of tetralone structures bearing various functionalities.
ChemInform Abstract: Selective Synthesis of Dibenzo[a,c]cyclooctatetraenes (IV) via Palladium‐Catalyzed [4 + 4] Cyclic Homocoupling of Borylvinyl Iodobenzene Derivatives (III).
Authors: Zhang Hui‐jun , Wei Junnian , Zhao Fei , Liang Yun , Wang Zitao , Xi Zhenfeng 
Published: December 2010

AbstractSubstrates (IIIf) and (IIIg), bearing electron‐withdrawing groups at the phenyl ring, can not be transformed to the desired products (IV).
ChemInform Abstract: Potassium‐Tertiary Butoxide‐Assisted Addition of Thioglycolic Acid to Chalcone Derivatives under Solvent‐Free Conditions.
Authors: Ceylan Mustafa , Guerdere Meliha Burcu , Gezegen Hayreddin , Budak Yakup 
Published: December 2010

AbstractThe mechanistic pathway of the presented reaction can be explained by the Michael‐type addition of thioglycolic acid to chalcone derivatives (I).
ChemInform Abstract: Efficient One‐Pot Synthesis of 2‐Arylbenzo[b]furans from 2‐Styrylphenols Using CuBr2.
Authors: Bhatt Suchitra , Roy Kshama , Nayak Sandip K. 
Published: December 2010

AbstractThe title compounds (III) and (VI) are prepared by a novel and convenient protocol which has the advantage of experimental simplicity and the use of an inexpensive reagent.
ChemInform Abstract: Asymmetric Hydrogenation of Unfunctionalized Enamines Catalyzed by Iridium Complexes of Chiral Spiro N,N‐Diarylphosphoramidites.
Authors: Yan Pucha , Xie Jianhua , Zhou Qilin 
Published: December 2010

AbstractChiral spiro monophosphoramidites are synthesized and applied as ligands in the iridium‐catalyzed asymmetric hydrogenation of enamines (I), (III), and (V) to offer the corresponding chiral tertiary amines with moderate to high enantioselectivities.
ChemInform Abstract: Synthesis of Novel 4‐Fluoro‐2H‐pyrazol‐3‐ylamines.
Authors: Cocconcelli Giuseppe , Ghiron Chiara , Haydar Simon , Micco Iolanda , Zanaletti Riccardo 
Published: December 2010

AbstractA set of novel 4‐fluoro‐2H‐pyrazol‐3‐ylamines (IV) with different steric and electronic demands is synthesized.
ChemInform Abstract: Formation of Indazole Derivatives from 2,4‐Disubstituted Thiosemicarbazides and Some Chloro‐p‐quinones.
Authors: Hassan Alaa A. , Aly Ashraf A. , Mohamed Mamdouh A. 
Published: December 2010

AbstractReactions of 2,4‐disubstituted thiosemicarbazides (II) with chlorinated quinones follow a novel C—N—N + C2 addition mode furnishing indazole derivatives.
ChemInform Abstract: Synthesis of Trispiro[oxindole‐pyrrolidine]‐cyclopentanone‐isoxazolines by 1,3‐Dipolar Cycloaddition.
Authors: Li Xiaofang , Zheng Aiting , Liu Bin , Yu Xianyong , Yi Pinggui 
Published: December 2010

AbstractA range of novel aryl‐substituted trispiroheterocycles (VI) is prepared with high regio‐ and stereoselectivity via a tandem cycloaddition reaction of 2,5‐bis(arylmethylidene)cyclopentanones (III).
ChemInform Abstract: Green and Efficient Protocol for N‐Alkylation of Benzotriazole Using Basic Ionic Liquid [Bmim]OH as Catalyst under Solvent‐Free Conditions.
Authors: Le Zhang‐Gao , Zhong Tao , Xie Zong‐Bo , Lue Xue‐Xia , Cao Xia 
Published: December 2010

AbstractThe reaction is found to be general and applicable to alkyl halides containing bromide and chloride, and the desired products are obtained in good yields and moderate selectivity.
ChemInform Abstract: Facile Synthesis and Biological Evaluation of Some Ethoxyphthalimide Derivatives of Pyrazolylthiazoloisoxazoles and Pyrazolylthiadiazoles.
Authors: Thadhaney Bhawana , Sharma Shweta , Sharma Chirag , Talesara G. L. 
Published: December 2010

AbstractAll the title compounds (VIII), (XIII), and (XIV) display promising activity against pathogenic microbes.
ChemInform Abstract: Synthesis of 5‐Substituted 1H‐Tetrazoles from Nitriles and Hydrazoic Acid by Using a Safe and Scalable High‐Temperature Microreactor Approach.
Authors: Gutmann Bernhard , Roduit Jean‐Paul , Roberge Dominique , Kappe C. Oliver 
Published: December 2010

AbstractIn situ generation of HN3 from NaN3 and AcOH in a microreactor coupled to an intensified high‐temperature/high‐pressure flow addition step to nitriles yields tetrazole derivatives in good yields with excellent purities.
ChemInform Abstract: Highly Efficient Three‐Component, One‐Pot Synthesis of Dihydropyrano[3,2‐c]chromene Derivatives.
Authors: Wang Hong‐Juan , Lu Jie , Zhang Zhan‐Hui 
Published: December 2010

AbstractAldehydes, e.g. (III) and (V) (23 examples) are converted in a simple and efficient synthesis to known and novel chromene derivatives, (IV) and (VI), respectively.
ChemInform Abstract: 4‐Hydroxy‐2‐quinolones. Part 174. Hydrochlorides of [(Alkylamino)alkyl]amides of 1‐Allyl‐4‐hydroxy‐6,7‐dimethoxy‐2‐oxo‐1,2‐dihydroquinoline‐3‐carboxylic Acid — A New Class of Opiod Receptor Antagonists.
Authors: Ukrainets I. V. , Sidorenko L. V. , Davidenko A. A. , Yarosh A. K. 
Published: December 2010

AbstractIn pharmacological tests, hydrochlorides of the title compounds (VI) (10 examples) show promising results for the development of highly efficient opioid receptor antagonists.
ChemInform Abstract: An Unusual Reactivity of BBr3: Accessing Tetrahydroisoquinoline Units from N‐Phenethylimides.
Authors: Selvakumar Jayaraman , Makriyannis Alexandros , Ramanathan Chinnasamy Ramaraj 
Published: December 2010

AbstractA simple methodology to construct the tetrahydroisoquinoline containing skeleton through electrophilic activation of imide carbonyl group of N‐phenethylimides using BBr3 as Lewis acid is developed.
ChemInform Abstract: Yb(OTf)3: An Efficient Catalyst for the Synthesis of 3‐Arylbenzo[f]quinoline‐1,2‐dicarboxylate Derivatives via Imino‐Diels—Alder Reaction.
Authors: Wang Xiang‐Shan , Zhou Jie , Yang Ke , Yao Chang‐Sheng 
Published: December 2010

AbstractThe expected products are not obtained if aliphatic aldehydes are used.
ChemInform Abstract: Synthesis of Pyrazolo[3,4‐b]pyridine and Pyrido[2′,3′:3,4]pyrazolo[1,5‐a]pyrimidine Derivatives.
Authors: El‐Enany Mervat M. , El‐Meligie Salwa E. M. , Abdou Nadia A. , El‐Nassan Hala B. 
Published: December 2010

AbstractNovel compounds (IX), (XI), and (XIII) are evaluated for their antimicrobial potency (S.
ChemInform Abstract: The Synthesis of Phthalazin‐1(2H)‐ones and 3‐Hydroxyisobenzofuran‐1(3H)‐ones via the Ring Contraction of Tropones.
Authors: Li Wenjuan , Li Haijun , Li Zhiping 
Published: December 2010

AbstractThe reaction of functionalized tropones (I) with aryl hydrazines is studied.
ChemInform Abstract: Synthesis of 2‐Arylquinazolin‐4(3H)‐one Derivatives Catalyzed by Iodine in [bmim+][BF‐4].
Authors: Wang Xiang‐Shan , Yang Ke , Zhang Mei‐Mei , Yao Chang‐Sheng 
Published: December 2010

AbstractIf the same reaction is carried out at room temperature, the intermediate (E)‐azomethines can be isolated in high yields.
ChemInform Abstract: New Azaborine‐Thiophene Heteroacenes.
Authors: Lepeltier Marc , Lukoyanova Olena , Jacobson Alex , Jeeva Shehzad , Perepichka Dmitrii F. 
Published: December 2010

AbstractSynthesis, crystallographic, spectral and electrochemical properties of novel polycyclic 22‐electron aromatic compounds consisting of alternating azaborine and thiophene rings are described.
ChemInform Abstract: Palladium‐Catalyzed Addition of Silyl‐Substituted Chloroalkynes to Terminal Alkynes.
Authors: Wada Tatsuya , Iwasaki Masayuki , Kondoh Azusa , Yorimitsu Hideki , Oshima Koichiro 
Published: December 2010

AbstractThe Pd‐catalyzed addition of chloroethynylsilanes (IIa), (IIb) to terminal alkynes proceeds with excellent regio‐ and stereoselectivity to afford the (Z)‐1‐chloro‐1,3‐enynes (III), (XI) and (XIII) in good yields.
ChemInform Abstract: Indoloditerpenes from an Algicolous Isolate of Aspergillus oryzae.
Authors: Qiao Ming‐Feng , Ji Nai‐Yun , Liu Xiang‐Hong , Li Ke , Zhu Qing‐Mei , Xue Qin‐Zhao 
Published: December 2010

AbstractNew compounds asporyzin A (I), asporyzin B (II) and asporyzin C (III), together with three known indoloditerpenes are isolated from an endophytic fungus Aspergillus oryzae.
ChemInform Abstract: Improved Synthesis of 28‐Norbrassinolide.
Authors: Khripach Vladimir A. , Zhabinskii Vladimir N. , Ermolovich Yurii V. 
Published: December 2010

AbstractStarting from the known stigmasterol‐derived aldehyde (I), an improved synthesis of polyhydroxylated title steroid (V) is described with the construction of the side‐chain carbon skeleton as key process.
ChemInform Abstract: Cu‐Catalyzed Asymmetric Michael Addition of Glycine Derivatives to α,β‐Unsaturated Malonates.
Authors: Hou Xuelong , Li Qing , Yao Jun , Dai Lixin 
Published: December 2010

AbstractThe title addition of glycine imines (I) to malonates (II) provides the Michael adducts (III) in high yields and moderate to good diastereo‐ and enantioselectivities.
ChemInform Abstract: Synthesis of Morphinans with Diversely Functionalized Benzoxazole Moieties.
Authors: Giran Levente , Gyulai Zsuzsanna , Antus Sandor , Berenyi Sandor , Sipos Attila 
Published: December 2010

AbstractThree different strategies are pursued for the synthesis of oxazole‐fused morphinans (IV), (VI), and (X).
ChemInform Abstract: Cytotoxic Evaluation of Pungencine (I): A New Tropane Alkaloid from the Roots of Erythroxylum pungens O. E. Schulz.
Authors: Sena‐Filho Jose G. , da Silva Marcelo S. , Tavares Josean F. , Oliveira Steno L. , Romero Marco A. V. , Xavier Haroudo S. , Barbosa‐Filho Jose M. , Braz‐Filho Raimundo 
Published: December 2010

AbstractThe novel tropane alkaloid (I) is isolated and its structure is elucidated.
ChemInform Abstract: Neopetrosiamine A, Biologically Active Bis‐piperidine Alkaloid from the Caribbean Sea Sponge Neopetrosia proxima.
Authors: Wei Xiaomei , Nieves Karinel , Rodriguez Abimael D. 
Published: December 2010

AbstractNeopetrosiamine A (I) displays strong in vitro activities against a panel of cancer cell lines.
ChemInform Abstract: Curvularides A—E: Antifungal Hybrid Peptide—Polyketides from the Endophytic Fungus Curvularia geniculata.
Authors: Chomcheon Porntep , Wiyakrutta Suthep , Aree Thammarat , Sriubolmas Nongluksna , Ngamrojanavanich Nattaya , Mahidol Chulabhorn , Ruchirawat Somsak , Kittakoop Prasat 
Published: December 2010

Abstractisolation and structure elucidation of curvularide A (Ia), B (II), C (Ib), D (III) and E (IV); curvularide B shows promising antifungal activity
ChemInform Abstract: Palladium‐Catalyzed Amination of Dihaloarenes: A Simple and Efficient Approach to Polyazamacrocycles
Authors: Averin Alexei D. , Uglov Alexei N. , Lemeune Alla , Guilard Roger , Beletskaya Irina P. 
Published: December 2010

AbstractReview: 76 refs.
Open Adsorption System for an Energy Efficient Dishwasher
Authors: Hauer Andreas , Fischer Fabian 
Published: December 2010

AbstractOpen adsorption systems using water as adsorbate, zeolite as adsorbent and air as heat and mass carrier can be used for heating, cooling and thermal energy storage (TES). In an adsorption cycle air is dehumidified, so drying processes are a promising field of application. The objective of the work presented was to reduce the energy consumption of a dishwasher by means of an open adsorption system. The water heating phase of the main washing cycle has been used to desorb a packed bed of zeolites. The common water heating phase before the drying of the dishes has been omitted and replaced by an adsorption phase in which the dishes are dried by hot air. In this context the adsorption system was used as a thermally driven heat pump and a thermal energy storage system. The energy consumption is reduced by 25 % compared to a conventional dishwasher.
The Hydrogen Issue
Authors: Armaroli Nicola , Balzani Vincenzo 
Published: December 2010

AbstractHydrogen is often proposed as the fuel of the future, but the transformation from the present fossil fuel economy to a hydrogen economy will need the solution of numerous complex scientific and technological issues, which will require several decades to be accomplished. Hydrogen is not an alternative fuel, but an energy carrier that has to be produced by using energy, starting from hydrogen‐rich compounds. Production from gasoline or natural gas does not offer any advantage over the direct use of such fuels. Production from coal by gasification techniques with capture and sequestration of CO2 could be an interim solution. Water splitting by artificial photosynthesis, photobiological methods based on algae, and high temperatures obtained by nuclear or concentrated solar power plants are promising approaches, but still far from practical applications. In the next decades, the development of the hydrogen economy will most likely rely on water electrolysis by using enormous amounts of electric power, which in its turn has to be generated. Producing electricity by burning fossil fuels, of course, cannot be a rational solution. Hydroelectric power can give but a very modest contribution. Therefore, it will be necessary to generate large amounts of electric power by nuclear energy of by renewable energies. A hydrogen economy based on nuclear electricity would imply the construction of thousands of fission reactors, thereby magnifying all the problems related to the use of nuclear energy (e.g., safe disposal of radioactive waste, nuclear proliferation, plant decommissioning, uranium shortage). In principle, wind, photovoltaic, and concentrated solar power have the potential to produce enormous amounts of electric power, but, except for wind, such technologies are too underdeveloped and expensive to tackle such a big task in a short period of time. A full development of a hydrogen economy needs also improvement in hydrogen storage, transportation and distribution. Hydrogen and electricity can be easily interconverted by electrolysis and fuel cells, and which of these two energy carriers will prevail, particularly in the crucial field of road vehicle powering, will depend on the solutions found for their peculiar drawbacks, namely storage for electricity and transportation and distribution for hydrogen. There is little doubt that power production by renewable energies, energy storage by hydrogen, and electric power transportation and distribution by smart electric grids will play an essential role in phasing out fossil fuels.
Polyvinylpyrrolidone storage disease presenting as pathologic fracture and anemia: Report of a case with imprint cytology
Authors: Huang Wen‐Chih , Chang Chih‐Hung , Tsai Chien‐Chen 
Published: December 2010

AbstractPolyvinylpyrrolidone (PVP) storage disease can be caused by local injection and systemic parenteral administration of PVP‐containing solutions. PVP has been used as plasma expander, a retardant in certain medicines, components of food additive, and hair care products. High‐molecular‐weight PVP polymers are prevented from renal excretion and are retained in the reticuloendothelial system. The clinical manifestations include skin lesions and hematologic and orthopedic complications because of bone marrow failure and bony destruction with infiltration of PVP storage histiocytes. Herein, we report a 65‐year‐old female patient with PVP storage disease presenting as femoral fracture and anemia. In our case, some gelatinous material was noted atthe fracture site, and the initial clinical impression was bony tumor or metastatic lesion. Imprint cytology showed some atypical cells exhibiting foamy cytoplasm and vacuoles. The biopsy specimen revealed that some blue‐grayish, vacuolated cells infiltrate in the bone marrow spaces and regional soft tissue near fracture site. The unusual morphology caused a diagnostic dilemma, with the differential diagnosis, including metastatic carcinoma, chordoma, liposarcoma, and hereditary storage disease. The vacuolated cells were positive for CD68, mucicarmine, and Congo red stains, but negative for CK (AE1/AE3) and S‐100 protein. Combing the patient's history with long‐term intravenous supplement of PVP‐containing blood solutions, PVP storage disease involving the bone and regional soft tissue was diagnosed. Diagn. Cytopathol. 2012. © 2010 Wiley Periodicals, Inc.