bluuebunny/crossref_metadata_2025_split huggingface dataset:
LINC00152: Potential driver oncogene in pan‐cancer
Authors: Xu Wei , Li Huiting , Wang Ziyao , Kang Yan , Zheng Luojie , Liu Yiping , Xu Ping , Li Zheng 
Published: May 2024

AbstractLong noncoding RNAs (lncRNA) are a class of non‐coding RNAs greater than 200 bp in length with limited peptide‐coding function. The transcription of LINC00152 is derived from chromosome 2p11.2. Many studies prove that LINC00152 influences the progression of various tumors via promoting the tumor cells malignant phenotype, chemoresistance, and immune escape. LINC00152 is regulated by multiple transcription factors and DNA hypomethylation. In addition, LINC00152 participates in the regulation of complex molecular signaling networks through epigenetic regulation, protein interactions, and competitive endogenous RNA (ceRNA). Here, we provide a systematic review of the upstream regulatory factors of LINC00152 expression level in different types of tumors. In addition, we revisit the main functions and mechanisms of LINC00152 as driver oncogene and biomarker in pan‐cancer.This article is categorized under:
RNA in Disease and Development > RNA in Disease
RNA Methods > RNA Analyses in Cells
RNA Interactions with Proteins and Other Molecules > RNA‐Protein Complexes
How Does Human-Centred Extended Reality Support Healthcare Students’ Learning in Clinical Conditions?
Authors: Mikkonen Kristina , Ferdinando Hany , Sobocinski Marta , Kuivila Heli , Pramila-Savukoski Sari , Vhitehead Tugba , Ropponen Paula , Myllylä Teemu , Paunonen Jari , Halili Erson , Koutonen Joel , Taikina-Aho Juha-Matti , Siipo Antti , Järvelä Sanna 
Published: May 2024

AbstractHealthcare education needs to be reformed to sustain quality, faster response to crises and ensure a rapid and efficient graduation path for future healthcare professionals. In this study, our multidisciplinary team has developed and tested a Human-centred extended reality (XR) to solve challenges in healthcare by connecting humans to technology in a human-centred, ethical way and by empowering end users through social innovation. In our study, we aimed to develop an intuitive XR virtual simulation environment with realistic scenarios and metahuman avatars, enabling team interaction to test and analyse participants’ real-time adaptation through a combination of neurophysiological and behavioural data collected by wearable sensors. This novel research offers a solution to complement clinical placements of nursing and medical students and ensure that students achieve the required competencies even if unexpected situations or crises threaten to interrupt the practice of competencies in real-life environments. Furthermore, by utilising the neurophysiological data, we can assess the learning event based on analysis of the recorded signals. The XR solutions can reduce nursing and medical students’ stress levels and enhance their resilience to work effectively in collaborative interprofessional teams.
A Mobile Application Can Be Used as an Alternative to the Traditional Preparation Method for Parents in Pediatric Day Surgery: A Randomized Controlled Trial
Authors: Kerimaa Heli , Haapea Marianne , Hakala Mervi , Serlo Willy , Pölkki Tarja 
Published: May 2024

AbstractBackground: Digital preparation programs for day surgery are now available through smartphones; however, research on the effectiveness of digital interventions among parents is lacking.Aim: This study aimed to assess the effectiveness of a mobile application intervention in preparing parents for pediatric day surgery and to describe the correlations between parents’ anxiety, stress, and satisfaction.Methods: A total of 70 parents of preschool children who were scheduled for elective day surgery were randomly divided into two groups: the intervention group (IG; n = 36) and the control group (CG; n = 34). The study took place in the pediatric day surgical department of a university hospital in Finland. The IG used a mobile application, while the CG used routine methods. Parents’ anxiety, stress and satisfaction were measured using validated instruments.Results: There was no significant difference in parental anxiety levels between the two groups, both before and after the surgery. After the surgery, both groups of parents reported feeling less anxious while at home. Pre-surgery, most parents experienced no/mild stress at home. However, post-surgery, intervention group parents reported significantly less stress at home than control group parents. The mean VAS score for parents’ satisfaction in both groups was high: 8.8 for the intervention group (SD 1.9) and 8.6 for the control group (SD 0.9). These mean scores did not significantly differ. Anxiety, stress, and satisfaction showed a significant correlation in most cases at both T1 and T4.Conclusions: A mobile application can serve as an alternative to the traditional method of preparing parents for pediatric day surgery.
Detection of Intestinal Tumors Outside the Visibility of Capsule Endoscopy Camera Utilizing Radio Signal Recognition
Authors: Särestöniemi Mariella , Taparugssanagorn Attaphongse , Iinatti Jari , Myllylä Teemu 
Published: May 2024

AbstractEarly cancer detection is crucial, especially for intestinal cancer with subtle early symptoms. While camera-based Wireless Capsule Endoscopy (WCE) systems are efficient, patient-friendly, and safe investigating gastrointestinal (GI) track thoroughly, some limitations persist in visualizing only the inner part of the GI regions. Our study introduces a radio channel analysis -based approach to detect intestinal/abdominal tumors which are not visible for the WCE camera, i.e., the tumors which have started to grow on the outer parts of the intestinal track. Focused on S-parameter patterns in realistic human voxel models, our simulation-based method discerns dielectric property variations in normal and tumorous tissues, replicating intricate tissue characteristics. Preliminary simulation results in different intestine locations demonstrate our technique’s efficacy in differentiating normal and tumor cases based on S-parameter patterns. With a 98% accuracy rate, simple logistic regression classification model excels in distinguishing normal from tumor tissues, significantly enhancing diagnostic precision in GI health monitoring showcasing its potential to revolutionize early cancer detection and advance diagnostic accuracy within simulated human anatomy. This represents a substantial stride toward improving healthcare outcomes through cutting-edge technology.
Two-loop amplitudes for $$ t\overline{t}H $$ production: the quark-initiated Nf-part
Authors: Agarwal Bakul , Heinrich Gudrun , Jones Stephen P. , Kerner Matthias , Klein Sven Yannick , Lang Jannis , Magerya Vitaly , Olsson Anton 
Published: May 2024

Abstract
We present numerical results for the two-loop virtual amplitude entering the NNLO corrections to Higgs boson production in association with a top quark pair at the LHC, focusing, as a proof of concept of our method, on the part of the quark-initiated channel containing loops of massless or massive quarks. Results for the UV renormalised and IR subtracted two-loop amplitude for each colour structure are given at selected phase-space points and visualised in terms of surfaces as a function of two-dimensional slices of the full phase space.
Variational autoencoders for regression: recovering fully leptonic $$ b\overline{b}{W}^{+}{W}^{-} $$ in di-Higgs searches
Authors: Alves Alexandre , da Silva Almeida Eduardo , Mesquita Igor Neiva 
Published: May 2024

Abstract
The search for double Higgs production in $$ b\overline{b}{W}^{+}{W}^{-} $$
b

b
¯

W
+

W
−

, where both W bosons decay to leptons, has been rehabilitated as a good option to investigate key processes within the Standard Model scalar sector at the LHC. The missing neutrinos, however, hinder the reconstruction of useful information like the Higgs pair mass, which is very sensitive to the trilinear Higgs self-coupling. We present a solution to that problem using a Variational Autoencoder for Regression (VAER) to reconstruct the Higgs and top pairs decays hh, $$ t\overline{t}\to b\overline{b}{W}^{+}{W}^{-}\to b\overline{b}{\ell}^{+}{\ell}^{\prime -}{\nu}_{\ell }{\overline{\nu}}_{\ell^{\prime }} $$
t

t
¯

→
b

b
¯

W
+

W
−

→
b

b
¯

ℓ
+

ℓ

′
−

ν
ℓ

ν
¯

ℓ
′

. The algorithm predicts the invariant mass of non-resonant hh independently of specific trilinear coupling values, even for events where the Higgs self-coupling were not included during its training. VAER is also able to identify a new Higgs resonance in an unsupervised way, showing generalization power for events not presented in its training phase. Finally, we demonstrate that VAER prediction is as useful to statistical inference as ground truth simulated distributions by computing a χ2 between trilinear coupling hypotheses based on binned invariant mass distributions of $$ b\overline{b}{\ell}^{+}{\ell}^{\prime -}{\nu}_{\ell }{\overline{\nu}}_{\ell^{\prime }} $$
b

b
¯

ℓ
+

ℓ

′
−

ν
ℓ

ν
¯

ℓ
′

.
Universal fine grained asymptotics of free and weakly coupled quantum field theory
Authors: Cao Weiguang , Melia Tom , Pal Sridip 
Published: May 2024

Abstract
We give a rigorous proof that in any free quantum field theory with a finite group global symmetry G, on a compact spatial manifold, at sufficiently high energy, the density of states ρα(E) for each irreducible representation α of G obeys a universal formula as conjectured by Harlow and Ooguri. We further prove that this continues to hold in a weakly coupled quantum field theory, given an appropriate scaling of the coupling with temperature. This generalizes similar results that were previously obtained in (1 + 1)-D to higher spacetime dimension. We discuss the role of averaging in the density of states, and we compare and contrast with the case of continuous group G, where we prove a universal, albeit different, behavior.
Measuring associativity: graph algebras of undirected graphs
Authors: Kátai-Urbán Kamilla , Waldhauser Tamás 
Published: May 2024

AbstractWe study two measures of associativity for graph algebras of finite undirected graphs: the index of nonassociativity and (a variant of) the semigroup distance. We determine “almost associative” and “antiassociative” graphs with respect to both measures. It turns out that the antiassociative graphs are exactly the balanced complete bipartite graphs, no matter which of the two measures we consider. In the class of connected graphs the two notions of almost associativity are also equivalent.
Cathepsin K deficiency prevented stress-related thrombosis in a mouse FeCl3 model
Authors: Jin Xueying , Yue Xueling , Huang Zhe , Meng Xiangkun , Xu Shengnan , Wu Yuna , Wan Ying , Inoue Aiko , Narisawa Megumi , Hu Lina , Shi Guo-Ping , Umegaki Hiroyuki , Murohara Toyoaki , Lei Yanna , Kuzuya Masafumi , Cheng Xian Wu 
Published: May 2024

Abstract
Background
Exposure to chronic psychological stress (CPS) is a risk factor for thrombotic cardiocerebrovascular diseases (CCVDs). The expression and activity of the cysteine cathepsin K (CTSK) are upregulated in stressed cardiovascular tissues, and we investigated whether CTSK is involved in chronic stress-related thrombosis, focusing on stress serum-induced endothelial apoptosis.

Methods and results
Eight-week-old wild-type male mice (CTSK+/+) randomly divided to non-stress and 3-week restraint stress groups received a left carotid artery iron chloride3 (FeCl3)-induced thrombosis injury for biological and morphological evaluations at specific timepoints. On day 21 post-stress/injury, the stress had enhanced the arterial thrombi weights and lengths, in addition to harmful alterations of plasma ADAMTS13, von Willebrand factor, and plasminogen activation inhibitor-1, plus injured-artery endothelial loss and CTSK protein/mRNA expression. The stressed CTSK+/+ mice had increased levels of injured arterial cleaved Notch1, Hes1, cleaved caspase8, matrix metalloproteinase-9/-2, angiotensin type 1 receptor, galactin3, p16IN4A, p22phox, gp91phox, intracellular adhesion molecule-1, TNF-α, MCP-1, and TLR-4 proteins and/or genes. Pharmacological and genetic inhibitions of CTSK ameliorated the stress-induced thrombus formation and the observed molecular and morphological changes. In cultured HUVECs, CTSK overexpression and silencing respectively increased and mitigated stressed-serum- and H2O2-induced apoptosis associated with apoptosis-related protein changes. Recombinant human CTSK degraded γ-secretase substrate in a dose-dependent manor and activated Notch1 and Hes1 expression upregulation.

Conclusions
CTSK appeared to contribute to stress-related thrombosis in mice subjected to FeCl3 stress, possibly via the modulation of vascular inflammation, oxidative production and apoptosis, suggesting that CTSK could be an effective therapeutic target for CPS-related thrombotic events in patients with CCVDs.
Maximum principles for elliptic operators in unbounded Riemannian domains
Authors: Bisterzo Andrea 
Published: May 2024

AbstractThe necessity of a Maximum Principle arises naturally when one is interested in the study of qualitative properties of solutions to partial differential equations. In general, to ensure the validity of these kinds of principles one has to consider some additional assumptions on the ambient manifold or on the differential operator. The present work aims to address, using both of these approaches, the problem of proving Maximum Principles for second order, elliptic operators acting on unbounded Riemannian domains under Dirichlet boundary conditions. Hence there is a natural division of this article in two distinct and standalone sections.
Nutritional insights into broths in relation to elemental composition
Authors: Kosečková Pavlína , Zvěřina Ondřej , Letková Katarína 
Published: May 2024

AbstractDespite the popular claim that broths are a good source of essential elements, few studies have been devoted to clarifying this narrative. In fact, there is growing concern about the risk of ingesting toxic elements. This study focused on assessing the content of important elements (Ca, Cd, Cu, Fe, K, Mg, Na, and Pb) in various types of broths (beef, fish, poultry, pork, and vegetable). The samples (n = 30) included broths of different origins, including laboratory-prepared broths and broths prepared by professional cooks from Czech school canteens. The broths were evaluated as potential sources of essential elements in relation to their reference daily intake, as well as their potential toxicity risk in relation to Cd and Pb. Although significant variability was observed in the contents of the investigated elements, the results generally contradicted the popular narrative that broths are a good source of Ca, Cu, Fe, and Mg, as their contents did not achieve even 5% of the recommended daily intake. The amount of Ca in the broths was minimal even compared to the amount in tap water. The consumption of broths poses minimal risk regarding the presence of Cd and Pb.
Graphic abstract
Yet another proof of the density in energy of Lipschitz functions
Authors: Lučić Danka , Pasqualetto Enrico 
Published: May 2024

AbstractWe provide a new, short proof of the density in energy of Lipschitz functions into the metric Sobolev space defined by using plans with barycenter (and thus, a fortiori, into the Newtonian–Sobolev space). Our result covers first-order Sobolev spaces of exponent $$p\in (1,\infty )$$

p
∈
(
1
,
∞
)

, defined over a complete separable metric space endowed with a boundedly-finite Borel measure. Our proof is based on a completely smooth analysis: first we reduce the problem to the Banach space setting, where we consider smooth functions instead of Lipschitz ones, then we rely on classical tools in convex analysis and on the superposition principle for normal 1-currents. Along the way, we obtain a new proof of the density in energy of smooth cylindrical functions in Sobolev spaces defined over a separable Banach space endowed with a finite Borel measure.
The effect of high values of relative surface roughness on heat transfer and pressure drop characteristics in the laminar, transitional, quasi-turbulent and turbulent flow regimes
Authors: Everts Marilize , Mahomed Faiyaad 
Published: May 2024

AbstractThis study investigated the effect of large values of relative surface roughness on the heat transfer and pressure drop characteristics using simultaneously measured heat transfer and pressure drop data. Experiments were conducted using a horizontal circular tube with a base inner diameter of 5 mm and length of 4 m. One smooth and two rough tubes, with relative roughnesses of 0.04 and 0.11, were tested at different constant heat fluxes between Reynolds numbers of 100 and 8 500. Water was used as the test fluid and the Prandtl number varied between 3 and 7. Contrary to the trend in the Moody Chart, a significant increase in laminar friction factors with increasing surface roughness was observed. Both the friction factors and Nusselt numbers as functions of Reynolds number showed a clear upward and leftward shift with increasing surface roughness across the different flow regimes. Furthermore, the boundaries between the flow regimes were the same for the pressure drop and heat transfer results. The width of the transitional flow regime was narrower for rough tubes and had a differing trend. The quasi-turbulent and turbulent flow regimes occurred at lower Reynolds numbers for increasing roughness. When investigating the relationship between heat transfer and pressure drop, it was found that an increase in surface roughness favoured heat transfer in the quasi-turbulent flow regime. This is useful for rough tubes as the quasi-turbulent flow regime onsets early with regards to the Reynolds number in tubes with large roughnesses.
The telovelar approach for fourth ventricular tumors in children: is removal of the posterior arch of C1 necessary?
Authors: Cho Anna , Lippolis Maria Aliotti , Herta Johannes , Dogan Muhammet , Hedrich Cora , Azizi Amedeo A. , Peyrl Andreas , Gojo Johannes , Czech Thomas , Dorfer Christian 
Published: May 2024

Abstract
Purpose
Various surgical nuances of the telovelar approach have been suggested. The necessity of removing the posterior arch of C1 to accomplish optimal tumor exposure is still debated. Therefore, we report on our experience and technical details of the fourth ventricular tumor resection in a modified prone position without systematic removal of the posterior arch of C1.

Methods
A retrospective analysis of all pediatric patients, who underwent a fourth ventricular tumor resection in the modified prone position between 2012 and 2021, was performed.

Results
We identified 40 patients with a median age of 6 years and a M:F ratio of 25:15. A telovelar approach was performed in all cases. In 39/40 patients, the posterior arch of C1 was not removed. In the remaining patient, the reason for removing C1 was tumor extension below the level of C2 with ventral extension. Gross or near total resection could be achieved in 34/39 patients, and subtotal resection in 5/39 patients. In none of the patients, a limited exposure, sight of view, or range of motion caused by the posterior arch of C1 was encountered, necessitating an unplanned removal of the posterior arch of C1. Importantly, in none of the cases, the surgeon had the impression of a limited sight of view to the most rostral parts of the fourth ventricle, which necessitated a vermian incision.

Conclusion
A telovelar approach without the removal of the posterior arch of C1 allows for an optimal exposure of the fourth ventricle provided that critical nuances in patient positioning are considered.
Short- and long-term outcome differences between patients undergoing left and right colon cancer surgery: cohort study
Authors: Kuliavas Justas , Marcinkevičiūtė Kristina , Baušys Augustinas , Bičkaitė Klaudija , Baušys Rimantas , Abeciūnas Vilius , Degutytė Austėja Elžbieta , Kryžauskas Marius , Stratilatovas Eugenijus , Dulskas Audrius , Poškus Tomas , Strupas Kęstutis 
Published: May 2024

Abstract
Purpose
Since the literature currently provides controversial data on the postoperative outcomes following right and left hemicolectomies, we carried out this study to examine the short- and long-term treatment outcomes.

Methods
This study included consecutive patients who underwent right or left-sided colonic resections from year 2014 to 2018 and then they were followed up. The short-term outcomes such as postoperative morbidity and mortality according to Clavien-Dindo score, duration of hospital stay, and 90-day readmission rate were evaluated as well as long-term outcomes of overall survival and disease-free survival. Multivariable Cox regression analysis was performed of overall and progression-free survival.

Results
In total, 1107 patients with colon tumors were included in the study, 525 patients with right-sided tumors (RCC) and 582 cases with tumors in the left part of the colon (LCC). RCC group patients were older (P < 0.001), with a higher ASA score (P < 0.001), and with more cardiovascular comorbidities (P < 0.001). No differences were observed between groups in terms of postoperative outcomes such as morbidity and mortality, except 90-day readmission which was more frequent in the RCC group. Upon histopathological analysis, the RCC group’s patients had more removed lymph nodes (29 ± 14 vs 20 ± 11, P = 0.001) and more locally progressed (pT3-4) tumors (85.4% versus 73.4%, P = 0.001). Significantly greater 5-year overall survival and disease-free survival (P = 0.001) were observed for patients in the LCC group, according to univariate Kaplan-Meier analysis.

Conclusions
Patients with right-sided colon cancer were older and had more advanced disease. Short-term surgical outcomes were similar, but patients in the LCC group resulted in better long-term outcomes.
Self-reported caffeine consumption miss-matched consumption measured by plasma levels of caffeine and its metabolites: results from two population-based studies
Authors: Laaboub Nermine , Ranjbar Setareh , Strippoli Marie-Pierre F. , Marques-Vidal Pedro , Estoppey-Younes Sandrine , Ponte Belen , Pruijm Menno , Vogt Bruno , Ansermot Nicolas , Crettol Séverine , Vandenberghe Frederik , Vollenweider Peter , Preisig Martin , Bochud Murielle , EAP Chin B. 
Published: May 2024

Abstract
Importance and objective
Self-reported caffeine consumption has been widely used in research while it may be subject to bias. We sought to investigate the associations between self-reported caffeine consumption and plasma levels of caffeine and its two main metabolites (paraxanthine and theophylline) in the community.

Methods
Data from two population-based studies (SKIPOGH1 and 2 (N = 1246) and CoLaus|PsyCoLaus (N = 4461)) conducted in Switzerland were used. Self-reported caffeine consumption was assessed using questionnaires. Plasma levels of caffeine and its metabolites were quantified by ultra-high performance liquid chromatography coupled to a tandem quadrupole mass spectrometer.

Results
In both studies, mean log plasma levels of caffeine and its two metabolites were over 6.48 (plasma levels = 652 ng/ml) when no caffeine consumption was reported. Subsequently, nonlinear associations between log plasma levels and self-reported caffeine consumption were observed in SKIPOGH, with a change of the slope at 3–5 cups of espresso per day in SKIPOGH1 but not SKIPOGH2. In CoLaus|PsyCoLaus, increased daily consumption of caffeinated beverages was associated with increased log plasma levels with a change of the slope at 3 cups. In both studies, declared caffeine consumption higher than 3–5 cups per day was not associated with higher plasma levels of caffeine and its metabolites.

Conclusion
Self-reports of no or low caffeine consumption and consumption of more than 3–5 cups of coffee should be interpreted with caution, with possible under- or over-estimation. Quantifying plasma levels of caffeine and its metabolites may contribute to a better estimation of caffeine intake.