bluuebunny/crossref_metadata_2025_split huggingface dataset:
Layered List Labeling
Authors: Bender Michael A. , Conway Alex , Farach-Colton Martin , Komlós Hanna , Kuszmaul William 
Published: May 2024

The list-labeling problem is one of the most basic and well-studied algorithmic primitives in data structures, with an extensive literature spanning upper bounds, lower bounds, and data management applications. The classical algorithm for this problem, dating back to 1981, has amortized cost O(log bn). Subsequent work has led to improvements in three directions: low-latency (worst-case) bounds; high-throughput (expected) bounds; and (adaptive) bounds for important workloads.
Perhaps surprisingly, these three directions of research have remained almost entirely disjoint---this is because, so far, the techniques that allow for progress in one direction have forced worsening bounds in the others. Thus there would appear to be a tension between worst-case, adaptive, and expected bounds. List labeling has been proposed for use in databases at least as early as PODS'99, but a database needs good throughput, response time, and needs to adapt to common workloads (e.g., bulk loads), and no current list-labeling algorithm achieve good bounds for all three.
We show that this tension is not fundamental. In fact, with the help of new data-structural techniques, one can actually combine any three list-labeling solutions in order to cherry-pick the best worst-case, adaptive, and expected bounds from each of them.
Mitigating Recommendation Biases via Group-Alignment and Global-Uniformity in Representation Learning
Authors: Cai Miaomiao , Hou Min , Chen Lei , Wu Le , Bai Haoyue , Li Yong , Wang Meng 
Published: May 2024

Collaborative Filtering (CF) plays a crucial role in modern recommender systems, leveraging historical user-item interactions to provide personalized suggestions. However, CF-based methods often encounter biases due to imbalances in training data. This phenomenon makes CF-based methods tend to prioritize recommending popular items and performing unsatisfactorily on inactive users. Existing works address this issue by rebalancing training samples, reranking recommendation results, or making the modeling process robust to the bias. Despite their effectiveness, these approaches can compromise accuracy or be sensitive to weighting strategies, making them challenging to train. Therefore, exploring how to mitigate these biases remains in urgent demand.
In this article, we deeply analyze the causes and effects of the biases and propose a framework to alleviate biases in recommendation from the perspective of representation distribution, namely Group-Alignment and Global-Uniformity Enhanced Representation Learning for Debiasing Recommendation (AURL). Specifically, we identify two significant problems in the representation distribution of users and items, namely group-discrepancy and global-collapse. These two problems directly lead to biases in the recommendation results. To this end, we propose two simple but effective regularizers in the representation space, respectively named group-alignment and global-uniformity. The goal of group-alignment is to bring the representation distribution of long-tail entities closer to that of popular entities, while global-uniformity aims to preserve the information of entities as much as possible by evenly distributing representations. Our method directly optimizes both the group-alignment and global-uniformity regularization terms to mitigate recommendation biases. Please note that AURL applies to arbitrary CF-based recommendation backbones. Extensive experiments on three real datasets and various recommendation backbones verify the superiority of our proposed framework. The results show that AURL not only outperforms existing debiasing models in mitigating biases but also improves recommendation performance to some extent.
From Binary Join to Free Join
Authors: Remy Wang Yisu , Willsey Max , Suciu Dan 
Published: May 2024

Over the last decade, worst-case optimal join (WCOJ) algorithms have emerged as a new paradigm for one of the most fundamental challenges in query processing: computing joins efficiently. Such an algorithm can be asymptotically faster than traditional binary joins, all the while remaining simple to understand and implement. However, they have been found to be less efficient than the old paradigm, traditional binary join plans, on the typical acyclic queries found in practice. In an effort to unify and generalize the two paradigms, we proposed a new framework, called Free Join, in our SIGMOD 2023 paper. Not only does Free Join unite the worlds of traditional and worst-case optimal join algorithms, it uncovers optimizations and evaluation strategies that outperform both.
In this article, we approach Free Join from the traditional perspective of binary joins, and re-derive the more general framework via a series of gradual transformations. We hope this perspective from the past can help practitioners better understand the Free Join framework, and find ways to incorporate some of the ideas into their own systems.
Bystander Effects, Pharmacokinetics, and Linker-Payload Stability of EGFR-Targeting Antibody-Drug Conjugates Losatuxizumab Vedotin and Depatux-M in Glioblastoma Models
Authors: Jain Sonia , Griffith Jessica I. , Porath Kendra A. , Rathi Sneha , Le Jiayan , Pasa Tugce I. , Decker Paul A. , Gupta Shiv K. , Hu Zeng , Carlson Brett L. , Bakken Katrina , Burgenske Danielle M. , Feldsien Thomas M. , Lefebvre Didier R. , Vaubel Rachael A. , Eckel-Passow Jeanette E. , Reilly Edward B. , Elmquist William F. , Sarkaria Jann N. 
Published: May 2024

Abstract

Purpose:
Antibody-drug conjugates (ADC) are targeted therapies with robust efficacy in solid cancers, and there is intense interest in using EGFR-specific ADCs to target EGFR-amplified glioblastoma (GBM). Given GBM’s molecular heterogeneity, the bystander activity of ADCs may be important for determining treatment efficacy. In this study, the activity and toxicity of two EGFR-targeted ADCs with similar auristatin toxins, Losatuxizumab vedotin (ABBV-221) and Depatuxizumab mafodotin (Depatux-M), were compared in GBM patient-derived xenografts (PDX) and normal murine brain following direct infusion by convection-enhanced delivery (CED).

Experimental Design:
EGFRviii-amplified and non-amplified GBM PDXs were used to determine in vitro cytotoxicity, in vivo efficacy, and bystander activities of ABBV-221 and Depatux-M. Nontumor-bearing mice were used to evaluate the pharmacokinetics (PK) and toxicity of ADCs using LC-MS/MS and immunohistochemistry.

Results:
CED improved intracranial efficacy of Depatux-M and ABBV-221 in three EGFRviii-amplified GBM PDX models (Median survival: 125 to &gt;300 days vs. 20–49 days with isotype control AB095). Both ADCs had comparable in vitro and in vivo efficacy. However, neuronal toxicity and CD68+ microglia/macrophage infiltration were significantly higher in brains infused with ABBV-221 with the cell-permeable monomethyl auristatin E (MMAE), compared with Depatux-M with the cell-impermeant monomethyl auristatin F. CED infusion of ABBV-221 into the brain or incubation of ABBV-221 with normal brain homogenate resulted in a significant release of MMAE, consistent with linker instability in the brain microenvironment.

Conclusions:
EGFR-targeting ADCs are promising therapeutic options for GBM when delivered intratumorally by CED. However, the linker and payload for the ADC must be carefully considered to maximize the therapeutic window.
Perivascular NOTCH3+ Stem Cells Drive Meningioma Tumorigenesis and Resistance to Radiotherapy
Authors: Choudhury Abrar , Cady Martha A. , Lucas Calixto-Hope G. , Najem Hinda , Phillips Joanna J. , Palikuqi Brisa , Zakimi Naomi , Joseph Tara , Birrueta Janeth O. , Chen William C. , Oberheim Bush Nancy A. , Hervey-Jumper Shawn L. , Klein Ophir D. , Toedebusch Christine M. , Horbinski Craig M. , Magill Stephen T. , Bhaduri Aparna , Perry Arie , Dickinson Peter J. , Heimberger Amy B. , Ashworth Alan , Crouch Elizabeth E. , Raleigh David R. 
Published: May 2024

Abstract
Meningiomas are the most common primary intracranial tumors. Treatments for patients with meningiomas are limited to surgery and radiotherapy, and systemic therapies remain ineffective or experimental. Resistance to radiotherapy is common in high-grade meningiomas and the cell types and signaling mechanisms that drive meningioma tumorigenesis and resistance to radiotherapy are incompletely understood. Here, we report that NOTCH3 drives meningioma tumorigenesis and resistance to radiotherapy and find that perivascular NOTCH3+ stem cells are conserved across meningiomas from humans, dogs, and mice. Integrating single-cell transcriptomics with lineage tracing and imaging approaches in genetically engineered mouse models and xenografts, we show NOTCH3 drives tumor-initiating capacity, cell proliferation, angiogenesis, and resistance to radiotherapy to increase meningioma growth and reduce survival. To translate these findings to patients, we show that an antibody stabilizing the extracellular negative regulatory region of NOTCH3 blocks meningioma tumorigenesis and sensitizes meningiomas to radiotherapy, reducing tumor growth and improving survival.
Significance: There are no effective systemic therapies to treat meningiomas, and meningioma stem cells are poorly understood. Here, we report perivascular NOTCH3+ stem cells to drive meningioma tumorigenesis and resistance to radiotherapy. Our results identify a conserved mechanism and a therapeutic vulnerability to treat meningiomas that are resistant to standard interventions.
Coronary Embolism Among Patients With ST‐Segment–Elevation Myocardial Infarction and Atrial Fibrillation: An Underrecognized But Deadly Association
Authors: Popovic Batric , Varlot Jeanne , Humbertjean Lisa , Sellal Jean Marc , Pace Nathalie , Hammache Nefissa , Fay Renaud , Eggenspieler Florian , Metzdorf Pierre Adrien , Camenzind Edoardo 
Published: May 2024

Background
The prevalence and impact of coronary emboli (CE) in patients with ST‐segment–elevation myocardial infarction (STEMI) and atrial fibrillation (AF) have not been specifically studied. The objective was to describe the clinical characteristics and outcomes of patients with AF and CE in a large series of patients with STEMI.

Methods and Results

We investigated 2292 consecutive patients with STEMI and among them 225 patients with AF: 46 patients with a STEMI related to CE (group A) and 179 patients with a STEMI related to an atherosclerotic cause (group B). Compared with the 2067 patients without AF and CE (group C), patients with AF and CE were older (73 versus 59 years,
P
<0.05), more likely to be female (43% versus 22%,
P
<0.05), and presented more frequently with cardiogenic shock at admission (26% versus 9%,
P
<0.05). The baseline characteristics of patients with AF (group A versus B) did not differ significantly according to STEMI pathogenesis. In the unadjusted analysis, the 45‐day mortality was higher in patients with CE and AF (group A versus group C: 20% versus 4%;
P
<0.05 and group A versus group B: 20% versus 8%,
P
=not significant); this trend persisted at 2‐year follow‐up (group A versus group C: 24% versus 6%;
P
<0.05 and group A versus group B: 24% versus 17%,
P
=not significant). After stabilized inverse exposure probability weighting adjustment, a higher 45‐day mortality rate was confirmed in patients with CE and AF (group A versus group C: 18% versus 5%,
P
<0.05).

Conclusions
In patients presenting with STEMI and AF, CE was associated with excess early mortality.

Registration

URL:
clinicaltrials.gov
. Identifier: NCT05679843.
Egypt: Recent Developments in Arbitration Law
Authors: Abdel Wahab Mohamed S. , Khaled Noha 
Published: May 2024

Abstract
There are ongoing arbitration-related developments and updates that are worthy of mentioning in Egypt. In 2022, Egypt has adopted a recent model BIT, wherein it included provisions related to third-party funding and has significantly amended the dispute resolution mechanism of the preceding BIT models, and reintroduced the reference to ICSID arbitration under more stringent conditions. Also, by mid-2023, the CRCICA revealed its new draft arbitration rules which introduced new provisions that are not included in the 2011 arbitration rules such as consolidation, multiparty and multiple contracts arbitrations, third-party funding, emergency arbitrator and expedited procedures. On the judicial level, there are significant decisions rendered by the Cairo Court of Appeal and the Court of Cassation addressing various issues including the following: (i) the allocation of costs is based on a legal provision and does not amount to a compensation for special damages; (ii) supplementary compensation can be awarded in the form of an interest at a set rate provided that it fulfills the legally prescribed conditions; (iii) the nationality of the arbitrator is not a fundamental requirement to be included in the award, as long as it can be revealed from the case file and unless the parties excluded a specific nationality; (iv) a judge is disqualified to hear a petition filed to reverse his/her own order refusing enforcement of an arbitral award (v) a party who does not challenge an arbitrator, who failed to disclose that he was sentenced a one-year prison for a charge involving moral turpitude, within the timeframe for challenging him/her, is considered having waived its right to object and consequently such undisclosed circumstance will not affect the validity of the award; and (vi) the interest rate set by the Central Bank of Egypt is applied to commercial loans between non-banking commercial parties and does not violate the principles of Islamic Shari’a.
Molecular phylogeny and morphology reveal two new wood-inhabiting fungal species (Basidiomycota) from China
Authors: WANG LU , KANG ZHENGLI , ZHOU HONGMIN , ZHAO CHANGLIN 
Published: May 2024

Wood-inhabiting fungi are found in living trees, decorticated wood of dead tree branches and trunks as well as manufactured wood products, and play an important role in forest ecosystems as an important group of decomposers. In this present study, two new wood-inhabiting fungal taxa, Candelabrochaete yunnanensis and Hyphodermella sinensis are proposed based on a combination of the morphological features and molecular evidence. Candelabrochaete yunnanensis is characterized by the farinaceous basidiomata with the flesh-pinkish to brownish vinaceous hymenial surface, a monomitic hyphal system with simple-septate generative hyphae, presence of the cylindrical septocystidia and ellipsoid basidiospores (4–5 × 2.5–3 µm). Hyphodermella sinensis is characterized by the membranaceous basidiomata having the white to slightly greyish hymenial surface, a monomitic hyphal system with clamp generative hyphae, presence of the clavate cystidia and ellipsoid basidiospores (4–6 × 3–4 µm). The phylogenetic tree inferred from ITS+nLSU sequences revealed that Candelabrochaete yunnanensis was nested into the family Irpicaceae within the order Polyporales, in which it was closely related to the species C. africana; Hyphodermella sinensis grouped into the genus Hyphodermella and clustered into the family Phanerochaetaceae, in which it grouped with H. aurantiaca and H. zixishanensis.
Multiple Mucosal Ulcers Induced by Ixekizumab: A Case Report
Authors: Zheng Cheng , He Xiao , Tang Xuxia 
Published: May 2024

Objectives: Ixekizumab, an interleukin (IL)-17A inhibitor, exerts its therapeutic effects in psoriasis by inhibiting the interleukin (IL)-17 signaling pathway. Common adverse reactions to ixekizumab include injection site reactions and upper respiratory tract infections (URIs), while occurrences of inflammatory bowel disease (IBD) and multiple mucosal ulcers are infrequent. We present a case of a 51-year-old man who developed multiple mucosal ulcers after ixekizumab treatment. Methods: A 51-year-old man presented to our hospital with a 1-month history of pharyngalgia. The flexible laryngoscope displayed mild hyperemia in the pharyngeal mucosa and tonsils, redness and swelling of the epiglottis, as well as multiple ulcers in the oral cavity, uvula, and epiglottis. These ulcers did not improve with conventional treatment. Results: Upon evaluation, the ulcers were an immune-related adverse event induced by ixekizumab. Consequently, a decision was made to discontinue the drug and initiate a therapeutic regimen including corticosteroids and thalidomide. Eventually, the patient’s symptoms abated. Conclusions: Biologics are now becoming increasingly popular in psoriasis. It is vital for clinicians to be aware of this potential adverse event and to identify and intervene early to alleviate patients’ suffering.
Teaching Culturally and Linguistically Diverse Learners: A Content Analysis of Teacher Professional Organizations’ Position Statements
Authors: Leider Christine Montecillo , Tigert Johanna , Norova Nasiba 
Published: May 2024

Background or Context:Teachers are often positioned as the main providers of educational equity and access for culturally and linguistically diverse learners (CLDLs). Teachers’ beliefs regarding this population can play a major role in their instructional and curricular decisions.Purpose, Objective, Research Question, or Focus of Study:In this study, we use a lens of professionalization to examine how teacher beliefs might be influenced during the in-service years of a teacher’s career through the role of teacher professional organizations.Research Design:We utilized document analysis to examine how CLDLs are discussed in the position statements from four long-standing teacher professional organizations (i.e., National Council for Teachers of English, National Science Teacher Association, National Council for Teachers of Mathematics, and National Council for Social Studies). One hundred and four position statements produced between 2000 and 2022 were analyzed.Conclusions or Recommendations:Findings revealed that most position statements employ generic language, rarely referring explicitly to CLDLs, their access to education, the need to consider their languages/cultures in instructional methods and materials, or ways to effectively prepare teachers to meet their needs. Findings suggest that teacher professional organizations should rethink their approach to crafting position statements to be both inclusive and specific in language. Implications for teacher professional development and future research are discussed.
Measuring psychotherapeutic processes in the context of psychedelic experiences: Validation of the General Change Mechanisms Questionnaire (GCMQ)
Authors: Wolff Max , Evens Ricarda , Mertens Lea J , Schmidt Christopher , Beck Jessica , Rutrecht Hans , Cherniak Aaron D , Gründer Gerhard , Jungaberle Henrik 
Published: May 2024

Background: Therapeutic and salutogenic effects of psychedelic drugs have been attributed to psychotherapeutic or psychotherapy-like processes that can unfold during the acute psychedelic experience and beyond. Currently, there are no psychometric instruments available to comprehensively assess psychotherapeutic processes (as conceptualized by empirical psychotherapy research) in the context of psychedelic experiences. Aims: We report the initial validation of the General Change Mechanisms Questionnaire (GCMQ), a self-report instrument designed to measure five empirically established general change mechanisms (GCMs) of psychotherapy—(1) resource activation, (2) therapeutic relationship, (3) problem actuation, (4) clarification, and (5) mastery—in the context of psychedelic experiences. Methods: An online survey in a sample of 1153 English-speaking and 714 German-speaking psychedelic users was conducted to evaluate simultaneously developed English- and German-language versions of the GCMQ. Results: The theory-based factor structure was confirmed. The five GCMQ scales showed good internal consistency. Evidence for convergent validity with external measures was obtained. Significant associations with different settings and with therapeutic, hedonic, and escapist use motives confirmed the hypothesized context dependence of GCM-related psychedelic experiences. Indicating potential therapeutic effects, the association between cumulative stressful life events and well-being was significantly moderated by resource activation, clarification, and mastery. Factor mixture modeling revealed five distinct profiles of GCM-related psychedelic experiences. Conclusion: Initial testing indicates that the GCMQ is a valid and reliable instrument that can be used in future clinical and nonclinical psychedelic research. The five identified profiles of GCM-related experiences may be relevant to clinical uses of psychedelics and psychedelic harm reduction.
Factors Associated With Incident and Recurrent Falls Among Men Enrolled in Evidence-Based Fall Prevention Programs: An Examination of Race and Ethnicity
Authors: Olokunlade Temitope , Benden Mark E. , Han Gang , Sherman Ledric D. , Smith Matthew Lee 
Published: May 2024

We examined factors associated with incident (one) and recurrent (2+) falls among 7207 non-Hispanic White (NHW) (89.7%), non-Hispanic Black (NHB) (5.0%), and Hispanic (5.3%) men ages ≥60 years with ≥1 chronic conditions, enrolled in an evidence-based fall program. Multinomial and binary regression analyses were used to assess factors associated with incident and recurrent falls. Relative to zero falls, NHB and Hispanic men were less likely to report incident (OR = 0.55, p < .001 and OR = 0.70, p = .015, respectively) and recurrent (OR = 0.41, p < .001 and OR = 0.58, p < .001, respectively) falls. Men who reported fear of falling and restricting activities were more likely to report incident (OR = 1.16, p < .001 and OR = 1.32, p < .001, respectively) recurrent and (OR = 1.46, p < .001 and OR = 1.71, p < .001, respectively) falls. Men with more comorbidities were more likely to report recurrent falls (OR = 1.10, p < .001). Compared to those who experienced one fall, men who reported fear of falling (OR = 1.28, p < .001) and restricting activities (OR = 1.31, p < .001) were more likely to report recurrent falls. Findings highlight the importance of multi-component interventions to prevent falls.
A Descriptive Study to Determine Anxiety and Depression Among Hospitalized Elderly Undergoing Abdominal Surgery Admitted in Nehru Hospital, PGIMER, Chandigarh
Authors: Tandon Ritika , Sharma Sunita , Thakur Mukta , Gupta Rajesh 
Published: May 2024

Background Hospitalized elderly people suffer from psychological distress due to negative changes in their lives. Hospitalization is stressful for elderly people, as they undergo various surgical and medical procedures. Mental illnesses such as depression and anxiety can be seen as major risk factors among the hospitalized geriatric population. Hence, the need was felt to undertake a study to determine anxiety and depression among hospitalized elderly. Objective To determine anxiety and depression among hospitalized elderly undergoing abdominal surgery at the Nehru Hospital, PGIMER, Chandigarh. Material and Methods A descriptive study was conducted on 60 hospitalized elderly patients. The sample was determined using the purposive sampling technique. The data was collected by interviewing patients as per the interview schedule comprising socio-demographic variables, clinical profile, Geriatric Depression Scale, and Geriatric Anxiety Scale. Results The study found that 31.7% of participants had mild anxiety, 46.7% had moderate anxiety, and 21.7% had severe anxiety. All study participants had mild depression. The present study found a significant relationship between anxiety and depression ( r = 0.348, p = .01). Conclusion There is a high prevalence of depressive and anxiety symptoms among hospitalized elderly undergoing abdominal surgery. The presence of psychiatric distress can worsen physical illness and lead to slow recovery. So appropriate mental health interventions must be planned for their management.