bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nicotine Amelioratesα-synuclein Pre-formed Fibril-Induced Behavioral Deficits and Pathological Features in Mice
Authors: Huang Zhangqiong , Pan Yue , Ma Kaili , Luo Haiyu , Zong Qinglan , Wu Zhengcun , Zhu Zhouhai , Guan Ying 
Published: May 2024

AbstractBackgroundEpidemiologic study suggests nicotine reduces risk of PD, could be potential treatment for Parkinson’s disease.ObjectiveTo study the effect of nicotine on behavioral phenotypes and pathological characteristics of mice induced by human alpha-synuclein preformed fibers (α-syn-PFF).MethodsMice were injected with 5 μg of human α-syn-PFF in the hippocampus while administering nicotine-containing drinking water (200μg/mL). After 1 month, the motor ability, mood, spatial learning, and memory ability of the Parkinson’s disease(PD)phenotype-like model were detected using open field, rotarod, Y maze, and O maze tests. The expression of pathological α-syn, apoptotic proteins and the numbers of glial cells and neural stem cells in the hippocampus of mice were detected using western blotting and immunofluorescence.ResultsNicotine significantly reduced pathological α-syn accumulation, α-syn serine 129 phosphorylation and cell death caused by PFF injection in the hippocampus of mice, inhibited the increase of glial, microglia and apoptotic cells, decreased the expression levels of PI3K and Akt.ConclusionsNicotine may have inhibitory effects on human α-syn-PFF-induced neuroinflammation and apoptosis. Thus, it reduces human α-syn-PFF-induced behavioral deficits and pathological changes in mice.
Single cell RNA sequencing reveals immunomodulatory effects of stem cell factor and granulocyte colony-stimulating factor treatment in the brains of aged APP/PS1 mice
Authors: Gardner Robert S. , Kyle Michele , Hughes Karen , Zhao Li-Ru 
Published: May 2024

AbstractAlzheimer’s disease (AD) leads to progressive neurodegeneration and dementia. AD primarily affects older adults with neuropathological changes including amyloid-beta (Aβ) deposition, neuroinflammation, and neurodegeneration. We have previously demonstrated that systemic treatment with combined stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF) (SCF+G-CSF), reduces Aβ load, increases Aβ uptake by activated microglia and macrophages, reduces neuroinflammation, and restores dendrites and synapses in the brains of aged APPswe/PS1dE9 (APP/PS1) mice. However, the mechanisms underlying SCF+G-CSF-enhanced brain repair in aged APP/PS1 mice remain unclear. This study used a transcriptomic approach to identify potential mechanisms by which SCF+G-CSF treatment modulates microglia and peripheral myeloid cells to mitigate AD pathology in the aged brain. After injections of SCF+G-CSF for 5 consecutive days, single-cell RNA sequencing was performed on CD11b+cells isolated from the brains of 28-month-old APP/PS1 mice. The vast majority of cell clusters aligned with transcriptional profiles of microglia in various activation states. However, SCF+G-CSF treatment dramatically increased a cell population showing upregulation of marker genes related to peripheral myeloid cells. Flow cytometry data also revealed an SCF+G-CSF-induced increase of cerebral CD45high/CD11b+active phagocytes. SCF+G-CSF treatment robustly increased the transcription of genes implicated in immune cell activation, including gene sets that regulate inflammatory processes and cell migration. Expression of S100a8 and S100a9 were robustly enhanced following SCF+G-CSF treatment in all CD11b+cell clusters. Moreover, the topmost genes differentially expressed with SCF+G-CSF treatment were largely upregulated in S100a8/9-positive cells, suggesting a well-conserved transcriptional profile related to SCF+G-CSF treatment in resident and peripherally derived CD11b+immune cells. This S100a8/9-associated transcriptional profile contained notable genes related to pro-inflammatory and anti-inflammatory responses, neuroprotection, and Aβ plaque inhibition or clearance. Altogether, this study reveals immunomodulatory effects of SCF+G-CSF treatment in the aged brain with AD pathology, which will guide future studies to further uncover the therapeutic mechanisms.
A Translaminar Spacetime Code Supports Touch-Evoked Traveling Waves
Authors: Gonzales Daniel L. , Khan Hammad F. , Keri Hayagreev V.S. , Yadav Saumitra , Steward Christopher , Muller Lyle E. , Pluta Scott R. , Jayant Krishna 
Published: May 2024

SUMMARYLinking sensory-evoked traveling waves to underlying circuit patterns is critical to understanding the neural basis of sensory perception. To form this link, we performed simultaneous electrophysiology and two-photon calcium imaging through transparent NeuroGrids and mapped touch-evoked cortical traveling waves and their underlying microcircuit dynamics. In awake mice, both passive and active whisker touch elicited traveling waves within and across barrels, with a fast early component followed by a variable late wave that lasted hundreds of milliseconds post-stimulus. Strikingly, late-wave dynamics were modulated by stimulus value and correlated with task performance. Mechanistically, the late wave component was i) modulated by motor feedback, ii) complemented by a sparse ensemble pattern across layer 2/3, which a balanced-state network model reconciled via inhibitory stabilization, and iii) aligned to regenerative Layer-5 apical dendritic Ca2+events. Our results reveal a translaminar spacetime pattern organized by cortical feedback in the sensory cortex that supports touch-evoked traveling waves.GRAPHICAL ABSTRACT AND HIGHLIGHTSWhisker touch evokes both early- and late-traveling waves in the barrel cortex over 100’s of millisecondsReward reinforcement modulates wave dynamicsLate wave emergence coincides with network sparsity in L23 and time-locked L5 dendritic Ca2+spikesExperimental and computational results link motor feedback to distinct translaminar spacetime patterns
Global atlas of predicted functional domains inLegionella pneumophilaDot/Icm translocated effectors
Authors: Patel Deepak T. , Stogios Peter J. , Jaroszewski Lukasz , Urbanus Malene , Sedova Mayya , Semper Cameron , Le Cathy , Takkouche Abraham , Ichii Keita , Innabi Julie , Patel Dhruvin H. , Ensminger Alexander , Godzik Adam , Savchenko Alexei 
Published: May 2024

AbstractLegionella pneumophilautilizes the Dot/Icm type IVB secretion system to deliver hundreds of effector proteins inside eukaryotic cells to ensure intracellular replication. Our understanding of the molecular functions of this largest pathogenic arsenal known to the bacterial world remains incomplete.By leveraging advancements in 3D protein structure prediction, we provide a comprehensive structural analysis of 368L. pneumophilaeffectors, representing a global atlas of predicted functional domains summarized in a database (https://pathogens3d.org/legionella-pneumophila). Our analysis identified 157 types of diverse functional domains in 287 effectors, including 159 effectors with no prior functional annotations. Furthermore, we identified 35 unique domains in 30 effector models that have no similarity with experimentally structurally characterized proteins, thus, hinting at novel functionalities.Using this analysis, we demonstrate the activity of thirteen domains, including three unique folds, predicted inL. pneumophilaeffectors to cause growth defects in theSaccharomyces cerevisiaemodel system. This illustrates an emerging strategy of exploring synergies between predictions and targeted experimental approaches in elucidating novel effector activities involved in infection.
Accessing new physics with an undoped, cryogenic CsI CEvNS detector for COHERENT at the SNS
Authors: Barbeau P. S. , Belov V. , Bernardi I. , Bock C. , Bolozdynya A. , Bouabid R. , Browning J. , Cabrera-Palmer B. , Conley E. , da Silva V. , Daughhetee J. , Detwiler J. , Ding K. , Durand M. R. , Efremenko Y. , Elliott S. R. , Erlandson A. , Fabris L. , Febbraro M. , Galindo-Uribarri A. , Green M. P. , Hakenmüller J. , Heath M. R. , Hedges S. , Johnson B. A. , Johnson T. , Khromov A. , Konovalov A. , Kozlova E. , Kumpan A. , Kyzylova O. , Link J. M. , Liu J. , Major A. , Mann K. , Markoff D. M. , Mattingly J. , Mueller P. E. , Newby J. , Ogoi N. , O’Reilly J. , Parno D. S. , Pérez-Loureiro D. , Penttila S. I. , Pershey D. , Prior C. G. , Queen J. , Rapp R. , Ray H. , Razuvaeva O. , Reyna D. , Rich G. C. , Rudik D. , Runge J. , Salvat D. J. , Sander J. , Scholberg K. , Shakirov A. , Simakov G. , Snow W. M. , Sosnovtsev V. , Stringer M. , Subedi T. , Suh B. , Sur B. , Tayloe R. , Tellez-Giron-Flores K. , Tsai Y.-T. , Vanderwerp J. , van Nieuwenhuizen E. E. , Varner R. L. , Virtue C. J. , Visser G. , Walkup K. , Ward E. M. , Wongjirad T. , Yang Y. , Yoo J. , Yu C.-H. , Zaalishvili A. 
Published: May 2024

We consider the potential for a 10 kg undoped cryogenic CsI detector operating at the Spallation Neutron Source to measure coherent elastic neutrino-nucleus scattering and its sensitivity to discover new physics beyond the standard model (BSM). Through a combination of increased event rate, lower threshold, and good timing resolution, such a detector would significantly improve on past measurements. We considered tests of several BSM scenarios such as neutrino nonstandard interactions and accelerator-produced dark matter. This detector’s performance was also studied for relevant questions in nuclear physics and neutrino astronomy, namely the weak charge distribution of Cs and I nuclei and detection of neutrinos from a core-collapse supernova.

Published by the American Physical Society
2024
Lights, camera, action! Adding showmanship to the hospitality servicescape and experiencescape to attract customers: a management perspective
Authors: McCartney Glenn , Liew Kim Yoke Angel 
Published: May 2024

PurposeRestaurants are challenged to secure attraction attributes that provide motives, satisfaction and experiences for guests. The social interaction between server and guest can provide. Our case study aims to examine the perspectives of hospitality executives towards showmanship and server performances in restaurants to enhance servicescape and elevate guest experiences.Design/methodology/approachA literature review examined employee showmanship as part of the cocreation of gastronomic experiences and servicescape. Additional data were obtained from semi-structured interviews with 15 hospitality executives affiliated with Macao’s integrated resorts (IRs), and the information was examined using thematic analysis.FindingsThe study outcomes showed management support for showmanship performed by servers or chefs in cocreating immersive memorable dining experiences and social media and user-generated content (UGC). This was perceived to distinguish a restaurant from the competition. However, server talent and showmanship interaction with guests must be well managed, and bundled with additional restaurant servicescape attributes.Practical implicationsThe comments from hospitality management provide key insights towards implementing and maintaining showmanship which will involve resource challenges including server artisan talent and restaurant design.Originality/valueServer showmanship social interaction and value cocreation with guests are rarely discussed, although a key part of guest restaurant motivation and in creating an immersive experience. We address the limited understanding of hospitality management assessment towards developing showmanship, providing practical perspectives to assist restaurant and bar management to integrate and develop showmanship to enhance customer dining experiences.
Do HR practices for employee lifecycle influence organisational outcomes equally in Asia? Evidence from the Indo-Thai food sector
Authors: Pathomphatthaphan Sarawut , Das Simanchala , Virat Keytapark 
Published: May 2024

PurposeThe primary purpose of this contextual study was three-fold: (1) to study the effect of HR practices on employee lifecycle (ELC) on organisational outcomes; (2) to investigate the mediating role of employee outcomes in the relationship between HR practices and organisational outcomes; (3) to assess the differences in HR practices of the Indian and Thai food processing industries.Design/methodology/approachThe study used random sampling to select 574 (278 Indian and 296 Thai) HR managers in food processing industries. A structured questionnaire was administered. The PLS-SEM was used to validate the relationships, while multiple group analysis (MGA) was employed to compare the HR practices.FindingsThe results revealed a significant influence of HR practices on organisational outcomes. Employee outcomes also mediate this influence. MGA results showed no significant variation in the effect of HR practices on organisational outcomes between India and Thailand.Practical implicationsHR practices must be aligned to suit country-specific business contexts to achieve organisational outcomes by improving employee outcomes. The findings would guide managers of the Indian and Thai food industries to develop tailor-made HR strategies.Originality/valueThis study contributes to comparative HRM in the Asian context by offering an empirically tested framework. Additionally, this comparative research offers insightful information on convergent best practices among Asian nations.
Digital leadership, business model innovation and organizational change: role of leader in steering digital transformation
Authors: Malik Mehreen , Raziq Muhammad Mustafa , Sarwar Naukhez , Tariq Adeel 
Published: May 2024

PurposeScholars and practitioners acknowledge that digital leadership can help organizations gain a competitive advantage. This article focuses on the characteristics, styles and skills needed for effective digital leadership. It looks at the role of digital leaders in innovating business models and introducing organizational change required for a successful digital transformation.Design/methodology/approachThis paper is based on a comprehensive literature review of digital transformation, digital leadership, business model innovation, and organizational culture. It draws on institutional theory (INT) the neo-institutional theory (NIT). It draws from Science Direct, Web of Science and Google Scholar publications. A proposition and a conceptual framework are developed based on evaluating and synthesizing the literature.FindingsWe find that specific leader characteristics (agility, participative, innovativeness and openness), styles (democratic and transformational) and skills (cognitive, social, technological and digital) enable successful business model innovation and organizational change, all of which allow successful digital transformation of firms.Originality/valueThe literature on digital transformation has not been well integrated with the leadership literature. This is particularly true in terms of the role digital leaders play in the successful digital transformation of firms. The conceptual framework and a way forward proposed in this paper introduce future research directions on the topic.
Mapping the landscape: unveiling the structural dynamics of industry platforms
Authors: Abed Alghani Khaled , Kohtamäki Marko , Kraus Sascha 
Published: May 2024

Purpose The proliferation of industry platforms has disrupted several industries. Firms adopting a platform business model have experienced a substantial expansion in size and scale, positioning themselves as the foremost valuable entities in market capitalization. Over the past two decades, there has been a substantial expansion in the body of literature dedicated to platforms, and different streams of research have emerged. Despite considerable efforts and the significant progress made in recent years toward a comprehensive understanding of industry platforms, there is still room for further harnessing the field’s diversity. As a result, the aim of this article is to examine the field’s structure, identify research concerns and provide suggestions for future research, thereby enhancing the overall understanding of industry platforms.Design/methodology/approach We conducted a thorough examination of 458 articles on the topic using bibliometric methods and systematic review techniques.Findings Through co-citation analysis, we identified five distinct clusters rooted in various bodies of literature: two-sided markets, industry platforms, digital platforms, innovation platforms and two-sided networks. Furthermore, the examination of these five clusters has revealed three key areas that demand further consideration: (1) terminologies, (2) classifications and (3) perspectives.Originality/value While previous reviews have provided valuable insights into the topic of industry platforms, none have explored the structure of the field so far. Consequently, as a first step toward advancing the field, we uncover the structure of the literature, identifying three major areas of concern. By addressing these concerns, our goal is to converge different clusters, thereby harnessing the diversity in the field and enhancing the overall understanding of industry platforms.
Safeguarding public facilities: a study on enhancing safety in mosque amenities through slip-resistance and surface innovations
Authors: Kim In-Ju 
Published: May 2024

Purpose
This study critically examines the safety aspects of ablution spaces in United Arab Emirates (UAE) mosques, emphasising the evaluation of smooth ceramic tile floorings prone to water accumulation. As an integral practice in Islamic worship, ablution spaces cater to a diverse demographic, making their safety a paramount concern. This study aims to meticulously assess slip-resistance properties and surface characteristics to provide practical recommendations for enhanced safety measures.

Design/methodology/approach
The investigation involves in situ measurements of traction properties and an extensive analysis of surface features in thirty mosques across the UAE. This comprehensive approach allows for identifying the unique challenges posed by ceramic tile floorings in ablution spaces. The study uses a portable tribometer for dynamic friction coefficient measurements, ensuring accurate slip-resistance evaluations. Surface texture analysis uses a portable profilometer to quantify roughness parameters.

Findings
The study’s findings significantly advance the comprehension of safety considerations in ablution spaces. Through empirical evidence and evidence-based insights, the research identifies immediate safety concerns and provides practical recommendations to create secure and inclusive environments within mosques. The emphasis lies on safeguarding the well-being of worshippers and contributing to the broader goal of safety in religious spaces.

Originality/value
The original contribution of this study lies in its dual focus on immediate safety concerns and the deeper understanding of unique safety challenges within ablution spaces. By offering evidence-based insights and practical recommendations, the research strives to make meaningful contributions to creating secure and inclusive environments within mosques.
Resilience evaluation model of photovoltaic industry chain based on grey-entropy-catastrophe progression method: a case study of Jiangsu province
Authors: Xu Lan , Wang Yaofei 
Published: May 2024

PurposeThe purpose of this study is to establish a grey-entropy-catastrophe progression method (CPM) model to assess the photovoltaic (PV) industry chain resilience of Jiangsu Province in China.Design/methodology/approachFirst, we designed the resilience evaluation index system of such a chain from two aspects: the external environment and internal conditions. We then constructed a PV industry chain resilience evaluation model based on the grey-entropy-CPM. Finally, the feasibility and applicability of the proposed model were verified via an empirical case study analysis of Jiangsu Province in China.FindingsAs of the end of 2022, the resilience level of its PV industry chain is medium-high resilience, which indicates a high degree of adaptability to the current unpredictable and competitive market, and can respond to the uncertain impact of changes in conditions effectively and in a timely manner.Practical implicationsThe construction of this model can provide reference ideas for related enterprises in the PV industry to analyze the resilience level of the industrial chain and solve the problem of industrial chain resilience.Originality/valueFirstly, an analysis of the entire industrial chain structure of the PV industry, combined with its unique characteristics is needed to design a PV industry chain resilience evaluation index system. Second, grey relational analysis (GRA) and the entropy method were adopted to improve the importance of ranking the indicators in the evaluation of the CPM, and a resilience evaluation model based on grey-entropy-CPM was constructed.
Determining the climate adaptive capacity of urban actors: a case study of Mongla port-townin Bangladesh
Authors: Rashid Md. Jubaer , Chowdhooree Imon , Aziz Tasfin , Hossain Meherab 
Published: May 2024

Purpose
In an urban environment, different types of actors (individuals, households, community groups, institutions, governmental organizations, nongovernmental organizations (NGO), community-based organizations (CBO) and public and private organizations, etc.) play critical roles in enhancing urban resilience to adapt to the impacts of climate change. To identify and prioritize aspects of climate resilience planning, this study aims to examine the potential impacts of climate change on diverse urban systems and evaluate the capacities of various actors to adapt to climatic stress.

Design/methodology/approach
This research selects Mongla, a coastal as well as port town in south-western Bangladesh that faces climate risks including frequent cyclones, storm surges and salinity intrusion due to sea-level and temperature rise, as reported in the National Climate Vulnerability Index 2018. This research uses the methodology proposed by ICLEI South Asia’s Climate Resilient Cities Action Plan and accesses different urban actors’ adaptive capacity for contributing to enhancing climate resilience based on three broad characteristics: the capacity to organize and respond, availability of resources and access to information. The cumulative scores of these characteristics aid in determining the climate adaptive capacity of each urban actor.

Findings
The identified 53 actors are grouped into four categories: government (local and national); international/local NGOs, CBOs and associations; community representatives and private sectors and groups and individuals. The group of NGOs, CBOs and associations has a higher overall adaptive potential than all other actor groups, according to the study. When it comes to practicing adaptive capacity, government institutions are in the second-highest position. But, the Khulna development authority, the government agency that is in charge of overseeing all forms of urban development, scored poorly on all fragile urban systems. However, the performance of the fourth group of urban actors is very subpar when it comes to adapting to climatic stress, which emphasizes the need for focused interventions.

Research limitations/implications
Variations in adaptive capacities to climate change across different actors are particularly useful for targeting actors with lower levels of climate adaptive capacities in Mongla town.

Originality/value
This paper particularly addresses the research gap in assessing the adapting capacity of urban actors in Mongla port-town. Policymakers and practitioners can create and carry out targeted interventions that address the particular needs and concerns of vulnerable actors by making use of the insights obtained from this kind of study, thereby assisting in the development of climate resilience in any urban area.