bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vacuolar H+‐ATPase in Diabetes, Hypertension, and Atherosclerosis
Authors: Wang Na , Ren Liwei , Danser A. H. Jan 
Published: April 2024

ABSTRACTVacuolar H+‐ATPase (V‐ATPase) is a multisubunit protein complex which, along with its accessory proteins, resides in almost every eukaryotic cell. It acts as a proton pump and as such is responsible for regulating pH in lysosomes, endosomes, and the extracellular space. Moreover, V‐ATPase has been implicated in receptor‐mediated signaling. Although numerous studies have explored the role of V‐ATPase in cancer, osteoporosis, and neurodegenerative diseases, research on its involvement in vascular disease remains limited. Vascular diseases pose significant challenges to human health. This review aimed to shed light on the role of V‐ATPase in hypertension and atherosclerosis. Furthermore, given that vascular complications are major complications of diabetes, this review also discusses the pathways through which V‐ATPase may contribute to such complications. Beginning with an overview of the structure and function of V‐ATPase in hypertension, atherosclerosis, and diabetes, this review ends by exploring the pharmacological potential of targeting V‐ATPase.
The Mendelssohn of the Eighteenth Century: Tonal Growth, Functional Fluidity and Formal Complication in the First Movement of the D Major Quartet, Op. 44 No. 1
Authors: Taylor Benedict 
Published: April 2024

ABSTRACTThis article examines the elaborate compositional processes at work in the opening movement of Mendelssohn's Quartet in D major, Op. 44 No. 1 (1838) in the service of advancing and further refining the application of contemporary Formenlehre to nineteenth‐century music. Most conspicuous of these features is the role taken by the key of F♯ minor, iii of the tonic, which assumes increasing prominence over the course of the exposition, culminating in a curious ostensible secondary theme (bar 71) which appears initially to contradict the tonality of A major just confirmed. This harmonic argument runs alongside a fluid approach to phrase and interthematic structure, in which not only are the erstwhile first theme and transitional material subject to functional transformation but the latter is further elided with potential secondary material, while no terminating cadence (or EEC) is present either. Current analytical approaches – foremost here, sonata theory – cannot fully elucidate the subtlety of Mendelssohn's procedure (one might variously argue for an overridden medial caesura, a secondary theme starting in multiple places, a continuous or even a failed exposition), and nonetheless, clear precedents for individual elements of Mendelssohn's design can be found earlier in the music of Haydn and Mozart. Mendelssohn's movement raises significant questions about recent approaches to theorising nineteenth‐century form and its relation to Classical precedents, not all of which can be easily answered.
Complete genome sequence of
Yokenella regensburgei
isolated from a patient with urinary tract infection in India
Authors: Sahni Rani Diana , V Aravind , Suji Thangamani , V Annie Sheeba , Jayanth Selvin Theodore 
Published: April 2024

ABSTRACT

Yokenella regensburgei
, an environmental organism, is an emerging pathogen in patients chiefly with immune suppression. We report the draft genome of
Y. regensburgei
, strain UU2206353, isolated from the urinary tract of an immunocompetent individual. The assembled genome consisted of 4,669,536 bp distributed over 20 contigs with 4,283 protein-coding genes.
Retrospective validation of a rapid Lyme fluorescent immunoassay in differentiating Lyme arthritis from other musculoskeletal presentations in children in a Lyme-endemic region
Authors: Donovan Alexis , Quilty Rebecca , Joy Bryn K. , Seddigh Shahriar , Coatsworth Heather , Gauthier Luke , Comeau Jeannette L. , Lang Bianca , Leblanc Jason , Hatchette Todd , Stringer Elizabeth 
Published: April 2024

ABSTRACT

Lyme arthritis can present similarly to other causes of joint pain and swelling including septic arthritis and other acute and chronic arthropathies of childhood. Septic arthritis, although rare, constitutes an orthopedic emergency and requires early surgical intervention to reduce the risk of permanent joint damage. Currently, results of standard serologic tests to diagnose Lyme disease take days to weeks, which is unhelpful in acute clinical decision-making. Thus, some children with Lyme arthritis are treated empirically for septic arthritis undergoing unnecessary invasive procedures and hospital admission while on inappropriate antibiotic therapy. We retrospectively validated the Quidel Sofia Lyme Fluorescent Immunoassay, a rapid serologic assay that can detect IgG and/or IgM antibodies to
Borrelia burgdorferi
in 10 minutes, in residual serum samples collected from 51 children who had Lyme arthritis and 55 children with musculoskeletal presentations who were Lyme negative. The sensitivity and specificity of the Sofia IgG to identify cases of Lyme arthritis in children were 100% (95% confidence interval [CI] of 93.0%–100%) and 96.4% (95% CI: 87.5%–99.6%), respectively. The positive likelihood ratio (LR) was 27.5 (95% CI 7–107), and the negative LR was 0.00 (95% LR 0.00–0.15). We propose that the Sofia IgG, a rapid method for identifying Lyme arthritis, may be useful in differentiating Lyme arthritis from other forms of arthritis. Used in conjunction with readily available clinical and laboratory variables, it could help to rapidly identify children who are at low risk of septic arthritis in Lyme-endemic regions.

IMPORTANCE
Lyme arthritis is a common manifestation of Lyme disease in children, with clinical features overlapping with other causes of acute and chronic joint pain/swelling in children. We have demonstrated that the Sofia IgG is a reliable test to rule in and rule out the diagnosis of Lyme arthritis in children with musculoskeletal presentations in a Lyme-endemic region. When used in conjunction with clinical and laboratory variables routinely considered when differentiating Lyme arthritis from other diagnoses, the Sofia IgG has the potential to fill an important gap in care, especially when acute decision-making is necessary. The Sofia IgG should be included in prospective research studies examining clinical prediction tools to identify children at low risk of septic arthritis.
Langmuir wave dynamics and plasma instabilities: Insights from generalized coupled nonlinear Schrödinger equations
Authors: Khater Mostafa M. A. , Elagan S. K. , Fawakhreh Anwar Jabor , Alsubei Beida Mohsen Tami , Vokhmintsev Aleksander 
Published: April 2024

This study aims to tackle the generalized coupled nonlinear Schrödinger ([Formula: see text] – [Formula: see text]) equations, with a focus on understanding their physical significance and stability, especially in the realm of plasma physics. These equations are crucial for grasping the complex dynamics of wave interactions within plasma systems, which are fundamental for phenomena like wave-particle interactions, turbulence, and magnetic confinement. We employ analytical methods such as the generalized rational ([Formula: see text]at) and Khater II ([Formula: see text]hat.II) techniques, along with characterizing the system using Hamiltonian principles, to carefully examine the stability of solutions. The relevance of this model extends across various plasma phenomena, including electromagnetic wave propagation, Langmuir wave dynamics, and plasma instabilities. By applying these analytical techniques, we derive solutions and investigate their stability using Hamiltonian dynamics, providing valuable insights into the fundamental behavior of nonlinear plasma waves. Our findings reveal the existence of stable solutions under specific conditions, thus advancing our understanding of plasma dynamics significantly. This research carries significant implications for fields such as plasma physics, astrophysics, and fusion research, where a deep understanding of plasma wave stability and dynamics is crucial. Essentially, our study represents a scholarly effort to offer fresh perspectives on the behavior of [Formula: see text] – [Formula: see text] equations within plasma systems, contributing to the academic discourse on plasma wave phenomena.
O Descanso da Vontade na Estética de Schopenhauer
Authors: Salviano Jarlee Oliveira Silva 
Published: April 2024

The text intends to do an analysis of Schopenhauer's aesthetics contained in the third book of his work "The World as will and representation" and in the supplement to this work (added in the second publication in 1844). So we take as guide the concept "denial of will", which relates his aesthetics to his ethics contained in the fourth book.
Older People and Connectivity: How Has the Pandemic Changed the Older Population’s Use of ICT s and Social Networks?
Authors: Mairal-Llebot María , Latorre-Cosculluela Cecilia , Liesa-Orús Marta , Cored-Bandrés Sergio 
Published: April 2024

Abstract
The arrival of the COVID-19 pandemic has triggered numerous changes in our lives. Digital tools have made it possible to continue with the development of tasks or activities of multiple kinds. This fact has not bypassed the elderly who often find themselves in a situation of inequality caused by the generational digital divide. Using a mixed methodology combining quantitative and qualitative techniques, this study aims to understand and analyze how this situation has influenced the use of ICT s and social networks by the elderly. The research participants are 415 students from the University of Experience of a Spanish university aged 55–84 years old. The results obtained show changes in the way participants relate to technology since the beginning of the pandemic in terms of time and purpose. It also highlights the need to take measures to combat the generational digital divide, a problem that older people recognize as their own.
The Social and Biomedical Hurdles Associated with COVID-19: Eclectic Contexts
Authors: Mungai Ndungi wa , Kang’ethe Simon Murote 
Published: April 2024

Abstract
The advent of COVID-19 continues to present social and biomedical challenges that this article endeavors to explore through a systematic critical review of the literature. The article has also benefited from the researchers’ intuition and experiences they have acquired from investigating trends of SARS-CoV-2 virus dynamics. It has also benefited from engaging in informal conversations with researchers and lay people interested in addressing the myriad challenges posed by COVID-19. Findings have generated the following thematic discussions: stigma and stigmatization surrounding the disease, skewed global response, gender disparity, human rights dynamics, vaccine dynamics and dilemmas, and poverty associated with coronavirus advent. The article concludes by recognizing both biomedical and socioeconomic implications and the emerging social disparities and unequal access to pharmacotherapeutics.
Accuracy and Feasibility of Using a Smartphone Application for Carbohydrate Counting Versus Traditional Carbohydrate Counting for Adults With Insulin-Treated Diabetes
Authors: Shehab Mohammad , Cohen Robert M. , Brehm Bonnie , Bakas Tamilyn 
Published: April 2024

Background: Patients with insulin-treated diabetes struggle with performing accurate carbohydrate counting for proper blood glucose control. Little is known about the comparative accuracy and feasibility of carbohydrate counting methods. Purpose: The purpose of this study was to determine whether carbohydrate counting using a smartphone application is more accurate and feasible than a traditional method. Theoretical/conceptual framework: Based on a conceptual model derived from the Technology Acceptance Model, feasibility was defined as usefulness, ease of use, and behavioral intention to use each method. Methods: A standardized meal was presented to 20 adults with insulin-treated diabetes who counted carbohydrates using traditional and smartphone methods. Accuracy was measured by comparing carbohydrate counting estimates with the standardized meal values. Perceived feasibility (usefulness, ease of use, behavioral intention) was measured using rating forms derived from the Technology Acceptance Model. Results: The number of training and estimation minutes were significantly higher for the traditional method than the smartphone method ( Z = −3.83, P < .05; Z = −2.30, P < .05). The traditional method took an additional 1.4 minutes for estimation and 12.5 minutes for training. There were no significant differences in accuracy between traditional and smartphone methods for carbohydrate counting (Wilcoxon signed-rank test, Z = −1.10, P = .28). There were no significant differences between traditional and smartphone methods for feasibility (usefulness, Z = −.10, P = .95; ease of use, Z = −.36, P = .72; or behavioral intention, Z = −.94, P = .35). Conclusion: While both traditional and smartphone methods were found to be similar in terms of accuracy and feasibility, the smartphone method took less time for training and for carbohydrate estimation.
Predictive Value of Nasal Nitric Oxide for Diagnosing Eosinophilic Chronic Rhinosinusitis: A Systematic Review and Meta-Analysis
Authors: Kim Do Hyun , Shin Hyesoo , Stybayeva Gulnaz , Hwang Se Hwan 
Published: April 2024

Objectives The primary aim of this study was to assess disparities in nasal nitric oxide (NO) levels between individuals diagnosed with eosinophilic chronic rhinosinusitis (ECRS) and those without ECRS. The second aim was to ascertain the comparative predictive efficacy of these nasal NO levels for the presence of ECRS. Methods A systematic analysis was conducted on relevant studies that compared nasal NO levels in individuals with ECRS and those without. Furthermore, the discriminatory capacity of nasal NO in distinguishing ECRS from non-ECRS cohorts was quantified. The risk of bias across studies was evaluated utilizing the Newcastle-Ottawa scale. Results The comprehensive review encompassed a total of 5 studies involving 470 participants. Findings revealed that patients diagnosed with ECRS exhibited significantly higher levels of nasal NO, as measured in parts per billion (ppb), compared to their non-ECRS patients. The mean difference was 130.03 ppb (95% confidence interval: [66.30, 193.75], I2 = 58.7%). The diagnostic odds ratio for nasal NO in identifying ECRS was 9.29 ([5.85, 14.75], I2 = 26.4%). The area under the summary receiver operating characteristic curve was 0.82. The correlation between sensitivity and false positive rate was 0.53, suggesting a lack of heterogeneity. Sensitivity, specificity, negative predictive value, and positive predictive value were 69% ([0.55, 0.79], I2 = 77.0%), 83% ([0.73, 0.90], I 2 = 68.5%), 77% ([0.69, 0.83], I 2  = 50.1%), and 75% ([0.67, 0.82], I 2  = 41.5%), respectively. Conclusion Nasal NO has the potential as a noninvasive diagnostic measure and endotype tool for ECRS.
Assessment of groundwater potential zone mapping for semi-arid environment areas using AHP and MIF techniques
Authors: Shinde Sachin P. , Barai Virendra N. , Gavit Bhau K. , Kadam Sunil A. , Atre Atul A. , Pande Chaitanya Baliram , Pal Subodh Chandra , Radwan Neyara , Tolche Abebe Debele , Elkhrachy Ismail 
Published: April 2024

AbstractGroundwater resources are essential for drinking water, irrigation, and the economy mainly in semiarid environments where rainfall is limited. Currently, unpredictable rainfall due to climate change and pollution on the Earth’s surface directly affects groundwater resources. In this area, most people depend on groundwater resources for irrigation and drinking purposes, and every summer, most of the area depends on groundwater in a semiarid environment. Hence, we selected two popular methods, the analytical hierarchy process (AHP) and multiple influence factor (MIF) methods, which can be applied to map groundwater potential zones. Nine thematic layers, such as land use and land cover (LULC), geomorphology, soil, drainage density, slope, lineament density, elevation, groundwater level, and geology maps, were selected for this study using remote sensing and geographic information system (GIS) techniques. These layers are integrated in ArcGIS 10.5 software with the help of the AHP and MIF methods. The map of the groundwater potential zones in the study area revealed four classes, i.e., poor, moderate, good, and very good, based on the AHP and MF methods. The groundwater potential zone area is 241.50 (ha) Poor, 285.64 (ha) moderate, 408.31 (ha) good, and 92.75 (ha) very good using the AHP method. Similarly, the MIF method revealed that the groundwater potential classes were divided into four classes: 351.29 (ha) poor, 511.18 (ha), moderate, 123.95 (ha) good, and 41.78 (ha) very good. The results were compared to determine which methods are best for planning water and land resource development in specific areas that have basaltic rock and drought conditions. Both groundwater potential zone maps were validated with water yield data. The receiver operating characteristic (ROC) curve and area under the curve (AUC) model results are found to be 0.80 (good) and 0.93 (excellent) using the MIF and AHP methods, respectively; hence, the AHP method is best for delineation of groundwater potential zone maps and groundwater resource planning. The present study’s framework and the results will be valuable for improving the efficiency of irrigation, conserving rainwater and maintaining the ecosystem in India.
Comparative chloroplast genomes of Dactylicapnos species: insights into phylogenetic relationships
Authors: Yang Shunquan , Chen Juntong , Li Zhimin , Huang Xianhan , Zhang Xu , Liu Qun , Tojibaev Komiljon , Sun Hang , Deng Tao 
Published: April 2024

Abstract
Background
Dactylicapnos is a climbing herbaceous vine, distributed from the Himalayas to southwestern China, and some of the species have important medicinal values. However, the chloroplast genomes of Dactylicapnos have never been investigated. In this study, chloroplast genomes of seven Dactylicapnos species covering all three sections and one informal group of Dactylicapnos were sequenced and assembled, and the detailed comparative analyses of the chloroplast genome structure were provided for the first time.

Results
The results showed that the chloroplast genomes of Dactylicapnos have a typical quadripartite structure with lengths from 172,344 bp to 176,370 bp, encoding a total of 133–140 genes, containing 88–94 protein-coding genes, 8 rRNAs and 37–39 tRNAs. 31 codons were identified as relative synonymous codon usage values greater than one in the chloroplast genome of Dactylicapnos genus based on 80 protein-coding genes. The results of the phylogenetic analysis showed that seven Dactylicapnos species can be divided into three main categories. Phylogenetic analysis revealed that seven species form three major clades which should be treated as three sections.

Conclusions
This study provides the initial report of the chloroplast genomes of Dactylicapnos, their structural variation, comparative genomic and phylogenetic analysis for the first time. The results provide important genetic information for development of medical resources, species identification, infrageneric classification and diversification of Dactylicapnos.
Sleep quality as a mediator between family function and life satisfaction among Chinese older adults in nursing home
Authors: Zhu Wenfen , Wang Yutong , Tang Jiao , Wang Fangyi 
Published: April 2024

Abstract
Background
The life satisfaction of the elderly in nursing home is the focus of social concern.The purpose of this study was to evaluate the effects of family function and sleep quality on life satisfaction among elderly individuals in nursing homes and examine the mediating effect of sleep quality between family function and life satisfaction.

Methods
A cross-sectional observational study was conducted .A total of 127 older adults who completed the Life Satisfaction Index A (LSI-A), the Family APGAR Index and the Pittsburgh Sleep Quality Index (PSQI) were recruited from four nursing homes in Chongqing, China.

Results
Life satisfaction was positively correlated with family function (r=0.434, p<0.01) and negatively correlated with PSQI (r = -0.514, p<0.01). PSQI was found to be negatively associated with family function (r=-0.387, p<0.01).Family function had a significant effect on PSQI (path a: β=-0.8459, 95% CI=-1.2029, -0.4889), and PSQI had a significant effect on life satisfaction (path b: β=-0.3916, 95% CI=-0.5407, -0.2425). The total effect (path c) and direct effect (path c') of family function on life satisfaction were significant (β=0.8931, 95% CI=0.5626, 1.2235 and β=0.56181, 95% CI=0.2358, 0.8879, respectively). The coefficient for the indirect effect of family function on life satisfaction through PSQI was statistically significant (β=0.3312, 95% CI=0.1628, 0.5588). PSQI played a partial mediating role between family function and life satisfaction, and PSQI mediated 32.58% of the total effect of family function on life satisfaction.

Conclusions
Family function and sleep quality were significant predictors of elderly people's life satisfaction in nursing homes. Sleep quality partially mediated the relationship between family function and life satisfaction.The interventions focused on promoting family function and improving sleep quality may be more helpful in improving elderly people's life satisfaction in nursing homes.
Hepatitis C virus subtype diversity and transmission clusters characteristics among drug users in Zhuhai, South China
Authors: Li Hongxia , Huang Huitao , Huang Wenyan , Du Man , Long Dongling , Xu Guangxian , Mei Wenhua , Huang Kaisong 
Published: April 2024

Abstract
Background
Hepatitis C virus (HCV) infection poses a major public health challenge globally, especially among injecting drug users. China has the world’s largest burden of HCV infections. However, little is known about the characteristics of transmission networks among drug user populations. This study aims to investigate the molecular epidemiology and transmission characteristics of HCV infections among drug users in Zhuhai, a bustling port city connecting Mainland China and its Special Administrative Regions.

Methods
Participants enrolled in this study were drug users incarcerated at Zhuhai’s drug rehabilitation center in 2015. Their sociodemographic and behavioral information, including gender, promiscuity, drug use method, and so forth, was collected using a standardized questionnaire. Plasmas separated from venous blood were analyzed for HCV infection through ELISA and RT-PCR methods to detect anti-HCV antibodies and HCV RNA. The 5’UTR fragment of the HCV genome was amplified and further sequenced for subtype identifications and phylogenetic analysis. The phylogenetic tree was inferred using the Maximum Likelihood method based on the Tamura-Nei model, and the transmission cluster network was constructed using Cytoscape3.8.0 software with a threshold of 0.015. Binary logistic regression models were employed to assess the factors associated with HCV infection.

Results
The overall prevalence of HCV infection among drug users was 44.37%, with approximately 19.69% appearing to clear the HCV virus successfully. Binary logistic regression analysis revealed that those aged over 40, engaging in injecting drug use, and being native residents were at heightened risk for HCV infection among drug user cohorts. The predominant HCV subtypes circulating among those drug users were 6a (60.26%), followed by 3b (16.7%), 3a (12.8%), 1b (6.41%) and 1a (3.85%), respectively. Molecular transmission network analysis unveiled the presence of six transmission clusters, with the largest propagation cluster consisting of 41 individuals infected with HCV subtype 6a. Furthermore, distinct transmission clusters involved eight individuals infected with subtype 3b and seven with subtype 3a were also observed.

Conclusion
The genetic transmission networks revealed a complex transmission pattern among drug users in Zhuhai, emphasizing the imperative for a targeted and effective intervention strategy to mitigate HCV dissemination. These insights are pivotal for shaping future national policies on HCV screening, treatment, and prevention in port cities.