bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimizing the extreme gradient boosting algorithm through the use of metaheuristic algorithms in sales forecasting
Authors: Gulsun Bahadir , Aydin Muhammed Resul 
Published: June 2024

Abstract

Accurate forecasting of future demand is essential for decision-makers and institutions in order to utilize the sources effectively and gain competitive advantages. Machine learning algorithms play a significant role in this mission. In machine learning algorithms, tuning hyperparameters could dramatically enhance the performance of the algorithm. This paper presents a novel methodology for optimizing the hyperparameters of Extreme Gradient Boosting (XGBoost), a prominent machine learning algorithm, by leveraging Artificial Rabbits Optimization (ARO), a recent metaheuristic algorithm, in order to construct a robust and generalizable forecasting model. Additionally, the study conducts an experimental comparison of ARO with two widely utilized metaheuristic algorithms, Genetic Algorithm (GA) and Artificial Bee Colony (ABC), by optimizing the eight different hyperparameters of XGBoost. For this experiment, 68,949 samples were collected. Furthermore, variables that have a significant effect on sales were investigated to enhance the reliability of the model. Ten independent variables, comprising a mixture of internal and external features including display size, financial indicators, and weather conditions, were identified. The experimental findings showcased that the implemented ARO-XGBoost model surpassed other implemented models, including the XGBoost model, Genetic Algorithm (GA) optimized XGBoost, and Artificial Bee Colony (ABC) optimized XGBoost models, across various evaluation metrics such as mean absolute percentage error. In summary, the use of artificial rabbits optimization, a recent metaheuristic algorithm, yielded satisfactory results for hyperparameter optimization of XGBoost. Furthermore, our proposed forecasting model is comprehensive and holds potential for serving as a valuable model for future studies.
Role and importance of quality control in improving compliance of Enhanced Recovery After Surgery ; how dose high compliance overcome postoperative complication?
Authors: Kim In Kyeong , Bae Jung Hoon , Park Soo Ji , Lee Yoon Suk , Lee In Kyu 
Published: June 2024

Abstract

ERAS has already been proven to reduce postoperative complication and length of hospital stay. However, in real practice, application may vary from center to center and not all can be applied equally. Accordingly, we sought to evaluate the role and importance of ERAS compliance through quality rather than the appropriateness of each individual item. In addition, the association between high compliance and postoperative complication was analyzed according to severity. Patients who underwent colon cancer surgery were divided into Phase I (before November 2019) and Phase II (from November 2019 to December 2022). Phase II included high risk patients over 65 years of age and with an ASA score more than 3, but there was no significant difference in compliance with Phase I (78.12 ± 11.70 vs. 76.92 ± 12.25%, P = 0.112). Total and minor complications significantly decreased, but major complications did not (25 [5.8%] vs. 26 [5.4%], P = 0.764). High compliance and Phase II were associated with lower complications and significantly reduced lengths of stay in all patients with complications; surgical stress-related inflammatory markers were significantly reduced. Although ERAS protocol compliance cannot prevent major surgery-related complications, high compliance enables earlier recovery and shorter hospital stays for patients with major complications by reducing surgical stress-related inflammatory responses.
Effect of sleep in the third trimester of gestational diabetes mellitus on maternal and infant outcomes
Authors: Xintong Li , Rongrong Bai , Ruimin Cao , Yingying Ge , Yide Hao , Lingling Cui , Dongmei Xu 
Published: June 2024

Abstract

Background
Sleep is a controllable way of daily life, which has a non-negligible impact on the pathogenesis and prevention of gestational diabetes mellitus (GDM).
Methods
The study recruited pregnant females who were diagnosed with GDM by OGTT and underwent MNT until delivery. We collected the basic information of the pregnant females and recorded the maternal and infant outcomes; the PSQI questionnaire was completed within 3 days after delivery according to the sleep condition in the month before delivery.
Results
PSQI questionnaire was found 217 pregnant females with GDM had PSQI ≤ 5 and 331 pregnant females with GDM had PSQI > 5. The scores of pregnant females with PSQI > 5 were greater than those of pregnant females with PSQI ≤ 5 in different dimensions, and pregnant females had the most pronounced time to sleep. GDM pregnant females with PSQI >5 had higher rates of cesarean section, incidence of obstructed labor/cephalopelvic disproportion, higher rates of assisted delivery, and higher levels of intrapartum hemorrhage than GDM pregnant females with PSQI ≤5. PSQI >5 and poor subjective sleep quality had an increased risk of pregnancy complications and adverse pregnancy outcomes; very poor subjective sleep quality had the highest risk of pregnancy complications and adverse pregnancy outcomes.
Conclusion
PSQI >5 and poor subjective sleep quality have an increased risk of pregnancy complications and adverse pregnancy outcomes, and pregnant females with very poor self-perceived sleep quality have the highest risk of pregnancy complications and adverse pregnancy outcomes.
The Impact of Remnant Cholesterol on Cardiovascular Fitness in Young Adults: Insights from NHANES
Authors: Qin Shiwei , Chen Junlong , Sun Min , Zhang Dongying 
Published: June 2024

Abstract

Background
Remnant cholesterol (RC) is associated with the occurrence, progression, and prognosis of cardiovascular diseases (CVD) in elderly populations. However, the relation between RC and cardiovascular fitness (CVF) in young populations remains inconclusive. This research aimed to analyze the correlation between RC levels and cardiovascular fitness (CVF) impairment among United States youth individuals.
Method
A cross-sectional analysis was performed utilizing datasets from the National Health and Nutrition Examination Survey (NHANES) 1999–2004, including 3,097 participants who underwent CVF testing and provided fasting blood sample. RC was considered total cholesterol (TC)-high-density lipoprotein cholesterol (HDL-C)-high-density lipoprotein cholesterol (LDL-C). Weighted multivariate logistic regression analyses were used to assess the relationship between RC levels and CVF impairment.
Results
The analysis revealed a significant association between higher RC levels and an increased risk of CVF impairment. After adjusting for confounding factors, with each unit (1mmol/L) increase in remnant cholesterol, the risk of impaired cardiovascular fitness increases by 65%. The restricted cubic spline (RCS) curves demonstrate a linear relationship between RC and the risk of impaired CVF. Interaction terms showed that the positive correlation between RC and the likelihood of impaired CVF was consistent across different population statuses and could be applicable in various demographic settings.
Conclusions
Elevated RC levels were associated with an increased risk of impaired CVF among young individuals. The finding emphasized the importance of monitoring RC levels in cardiovascular risk assessment for young populations, potentially guiding early prevention strategies.
Identification and validation of qRT-PCR reference genes for analyzing grape infection with gray mold
Authors: Tan Lina , Lu Lijuan , Sun Wen , Zhang Xinyuan , Liu Yanglin , Xiang Yan , Yan Hanwei 
Published: June 2024

Abstract

Background Grapes are highly valued for their nutritional and economic benefits, and have been widely studied for their biological attributes such as fruit development, quality formation, and stress resistance. One significant threat to grape quality is gray mold, caused by Botrytis cinerea, which can infect the flowers, fruits, leaves, and stems. The quantitative real-time PCR (qRT-PCR), known for its high sensitivity and quantitative accuracy, is an essential tool for analyzing gene expression related to the pathogenesis of gray mold, thereby providing deeper insights into the disease.
Result In this study, we aim to identify stable internal reference genes crucial for accurate gene expression analysis via qRT-PCR. Utilizing transcriptome data from grapes under various disease stresses, we identified twelve candidate reference genes with consistently high expression levels. The stability of these genes was assessed through delta-CT, geNorm, NormFinder, BestKeeper, and RefFinder analyses after establishing the cycling thresholds (Ct) in different grape varieties treated with Botrytis cinerea.
Conclusions Our findings reveal that VIT-17s0000g02750 and VIT-06s0004g04280 exhibit stable expression and are suitable as new reference genes. This foundational work supports further research into the molecular mechanisms of grape biological processes.
Pattern of recurrence after fractionated stereotactic reirradiation in adult glioblastoma
Authors: Margulies Agathe , Sahki Nassim , Rech Fabien , Vogin Guillaume , Blonski Marie , Peiffert Didier , Taillandier Luc , Lesanne Grégory , Demogeot Nicolas 
Published: June 2024

Abstract

Background
Glioblastomas all eventually relapse after initial treatment, and an option to treat these recurrences is fractionated stereotactic reirradiation (fSRT). The location of recurrences following reirradiation has not been studied for fSRT delivered by a dedicated stereotactic device. We aimed to analyze these locations to better elucidate safety margins, dose and fractionation regimens.
Methods
We retrospectively analyzed the data of patients with glioblastoma recurrence that had been reirradiated by fSRT in October 2010-December 2020, in 25 Gy in 5 fractions delivered by a CyberKnife® at Institut de Cancérologie de Lorraine. We matched the images of the relapse post-fSRT relapse with the stereotactic radiation treatment planning scan to determine the relapse location.
Results
The location of recurrences after fSRT was “out-field” in 43.5%, “marginal” in 40.3%, and “in-field” in 16.1% of patients (N = 62). A GTV-PTV margin of 1 mm (versus 2 or 3 mm, HR = 0.38 [0.15–0.95], p = 0.037) and a PTV volume of ≥ 36cc (HR = 5.18 [1.06–25.3], p = 0.042) were significantly associated with the “marginal” recurrences. Being ≥ 60 years old at initial treatment (HR = 3.06 [1.17–8.01], p = 0.023) and having one or more previous recurrences (HR = 5.29 [1.70–16.5], p = 0.004) were significantly associated with “out-field” recurrences. The median PFS from fSRT was 3.4 months, and OS from diagnosis and from fSRT were 25.7 and 10.8 months respectively.
Conclusion
Reirradiation of glioblastoma recurrence by fSRT with 25 Gy in 5 fractions provides good local control.
An exploration of the effect of Belt and Road Initiative on the Export-Embodied Carbon Emissions in China’s Manufacturing Industry
Authors: Jiang Wenhui , Mukhopadhaya Pundarik , Zhang Hai 
Published: June 2024

Abstract

This study evaluates the impact of China’s Belt and Road Initiative (BRI) on direct and indirect carbon emissions from China’s manufacturing goods production and trade processes with 64 countries along the belt and road (B&R). The analysis is based on China’s 189 trading partners (countries and regions) and 26 industrial sectors using the Eora Global Multi-Regional Input-Output Database for 2001–2016 and the difference-in-differences (DID) method. The results indicate that to most countries along the B&R, the export-embodied carbon emissions in China's manufacturing industry exceed import-carbon emissions. Energy and heavy industries are the main net exporters of carbon emissions. It is noted that the contribution of the BRI is significant in the increase in the embodied carbon emissions of China’s manufacturing exports. The BRI’s effect is more obvious in energy and heavy manufacturing, in Maritime Silk Road countries and in developing countries along the B&R. While the BRI fosters embodied carbon emissions in China's manufacturing exports by promoting these exports, and reduces them by promoting low-carbon technological innovation, improving China’s relative position in the global value chain in the region does not affect manufacturing export carbon emissions. Our findings lead to several important policy implications at a time when the region is experiencing enormous challenges in reducing CO2 emissions.
The safety and economic evaluation of bevacizumab and PD-1 inhibitors for advanced non- squamous NSCLC: a multicenter observational study in China
Authors: Hu Min , Diao Changdong , Liu Jinmei , Wang Xiong , Yuan Qi , Li Shijun , Di Guojie , Ke Hongqin , Zhang Ge , Xu Zhuoran , Lou Chaoxuan , Xue Yanli , Zhang Yu , Shi Chen 
Published: June 2024

Abstract

Background
With the increasing number of indications approved for bevacizumab, evaluating its safety after marketing is essential. Besides, for patients with advanced non-squamous non-small-cell lung cancer (NSCLC), adding bevacizumab or PD-1 inhibitors to first-line doublet chemotherapy is routine. However, the optimal targeted therapy has yet to be defined. It is essential to discuss which scheme is safer, more effective, and more economical based on a comprehensive clinical evaluation.
Methods
The study utilized drug-based, non-invasive, observational, and uncontrolled methods to evaluate the safety of bevacizumab and was performed at six sites in China. By univariate and multivariate analysis, bevacizumab administration to inpatients with malignant tumors was studied for incidence and risk factors of adverse events (AEs). Moreover, the economic evaluation was conducted by comparing bevacizumab with PD-1 inhibitors through cost-effectiveness analysis.
Results
During a safety evaluation study of bevacizumab, a target population of 533 patients was assessed and it was found that AEs occurred in 86.26% of clinical cases. Anemia was the most common AE, accounting for 28.33% of cases. 26.45% of AEs were grade 3 or higher. The blood and lymphatic system had the highest incidence of severe AEs, followed by the cardiovascular system. Hypertension was the most common severe AE, occurring in 3.75% of patients. The study identified certain risk factors for AEs induced by bevacizumab through multivariate analysis in clinical practice. In pharmacoeconomic evaluation, each one percentage point increase in 1-year disease control rate (DCR) associated with bevacizumab relative to PD-1 inhibitors was associated with an additional cost of ¥164.16 per treatment cycle in the first-line treatment of common mutation-negative advanced non-squamous NSCLC.
Conclusions
The safety profile of bevacizumab is well-established and manageable. PD-1 inhibitors offer more pharmacoeconomic advantages over bevacizumab in treating advanced non-squamous NSCLC without common mutations.
The effect of a mixed circuit training on muscle synthesis’s indices, neurotrophic factors, and physical fitness in elderly women: A randomized controlled trial
Authors: Baharavar Fatemeh , Vakili Javad , Sari-Sarraf Vahid , Pourmanaf Hadi 
Published: June 2024

Abstract

Background: Regular physical activity can improve muscle synthesis, cognitive function, and physical fitness and consequently delay the side effects of aging. However, the effect of circuit training which is a combination of resistance and aerobic exercise is still unknown. Therefore, this study aimed to evaluate the effect of 8 weeks of a mixed circuit of aerobic and resistance training on serum levels of muscle synthesis indices, neurotrophic factors, and physical fitness in elderly women.
Methods: A total of 24 healthy elderly females (age 65±3 years) were recruited and randomly divided into two groups as follows: Mixed Circuit Training (MCT, n=12) and Control (C, n=12). Participants in the MCT group performed circuit training (three times a week at an intensity of 40-60% of 1 repetition maximum) for 8 weeks. Participants in the C group did not received any intervention. Serum levels of growth hormone (GH), Insulin-like growth factor-1 (IGF_1), brain derived neurotrophic factor (BDNF), nerve growth factor (NGF), and physical fitness (cardiovascular fitness, muscular endurance, and balance) were measured before and after the eight weeks of intervention.
Results: Serum levels of GH, IGF-1, BDNF, and, NGF were increased in the MCT group after eight weeks (p ˂0.001). Cardiovascular fitness, muscular endurance, and balance were also improved in the MCT group after eight weeks of intervention (p ˂0.001).
Conclusions: A mixed circuit training could improve muscle synthesis, neurotrophic factors, and physical fitness in elderly women. To confirm these results, further studies are recommended.
Trial registration
Retrospectively registered. IRCT20240108060648N1. Registration date: 2024/02/12. URL: https://irct.behdasht.gov.ir/search/result?query=IRCT20240108060648N1
Is the use of topical 25% magnesium sulfate (Epsom salt) effective in relieving perineal pain during immediate postpartum care: A randomized controlled trial
Authors: Desranleau Jacinthe , Flamand Audrey , Leclerc Vanessa , Lajeunesse Judith , Lefebvre Aizhen Jade , Prévost Anne-Patricia , Chen Lois , Deng Elizabeth , Rouillard Jean-Sébastien Di Fruscia , Doyer Elysa , El-Hawli Rim , Harvey-Lavoie Simonne , Pagliarulo-Fréchette Léah , Piché Jacqueline , Pigeon Camille , Bujold Stéphanie , Fredette Jessica Hardy , Pellerin Mélissa , Rajotte Elisabeth , Séguin Valérie , Stassiouk Alicia , Lambert Ariane , Roger Antoine 
Published: June 2024

Abstract

Background
Despite the high frequency of perineal trauma in obstetrics, management of perineal care and pain is highly variable, relying on very few studies, if any. Treatment of the perineum with compresses soaked in a magnesium sulfate (Epsom salt) solution has not previously been studied but is routinely used in some hospitals in Quebec, Canada.
Objectives
This study aims to determine whether compresses soaked in 25% magnesium sulfate in sterile water can alleviate perineal pain in women immediately after childbirth. Population and intervention: Women who have just given birth vaginally and report perineal or vulvar pain of 3/10 or more will be recruited and randomized into an intervention group receiving the treatment (compresses soaked in 25% magnesium sulfate) or a control group receiving a placebo (compresses soaked in water).
Methods
This multi-centric, double-blinded randomized clinical trial will be conducted in four hospitals in the province of Quebec, Canada. We plan to recruit a total of 104 participants. Participants will be instructed to apply the compresses on the vulva and perineum for 15 minutes, four times per day, if needed. They will be asked to score their pain before and after using the compresses for the length of their hospital stay, typically between 24 and 48 hours. Secondary outcomes include analgesic use, incidence of complications, participant satisfaction, opinions on feasibility, and any adverse effects caused by the compresses.
Discussion
This randomized controlled trial will assess whether the treatment is more effective in relieving pain than the placebo. The study will also determine the safety and feasibility of this method for routine postnatal care. This study could contribute in the long term to the standardization of evidence-based practices for the management of postpartum perineal pain in Canadian hospitals. Trial registration: ClinicalTrials.gov, NCT06393608. Registered 26 april 2024. https://clinicaltrials.gov/study/NCT06393608
Cybersickness risk management for a Virtual training tool dedicated to Airline pilots
Authors: Collet Anne-Claire , Drouot Stéphane , Aujeu Eric , Nemmi Federico , Buratto Florence , Bach Cédric 
Published: June 2024

Abstract

In the professional training field, virtual reality (VR) has received growing interest due to the advantages it provides over traditional means such as simulators: it is immersive but portable. However, the unpleasant side-effects of virtual reality, grouped under the term of cybersickness have hindered or slowed its widespread adoption. In the present study, we investigated the impact of a VR procedure trainer, dedicated to airline pilots, on their vision and well-being. The airline pilots’ license is subject to medical criteria, particularly regarding eyesight. It is thus mandatory to check that VR use will not impact their vision. Moreover, most laboratory studies exploring cybersickness and/or impacts on vision are based on young subjects (< 40 years old). Since the training tool targeted a broader age ranged population (20–60 y.o.), only pilots in the underrepresented age-range were included (i.e. 40-60y.o). 26 professional pilots took part to the experiment, included in 2 successive waves (14 pilots in the 1st group, 12 in the second). They performed three VR sessions on three consecutive days of increasing duration from 20 to 60 minutes. Their cybersickness symptoms were tracked, and accommodation and convergence parameters were measured before and after exposure. We did not find any deleterious impact on vision, and observed mild cybersickness symptoms in the first group, that led the team to suppress a short part of a lesson that was designated as problematic by all pilots. We did not observe any cybersickness symptoms in the second group following this modification. By systematically assessing the well-being of pilots during and after VR exposure, we managed the cybersickness risk.
miR-6760-5p suppresses neoangiogenesis by targeting Yes-associated protein 1 in patients with moyamoya disease undergoing indirect revascularization
Authors: wen Yunyu , chen junda , Long Tinghan , Chen Fangzhou , Wang Zhibin , Chen Siyuan , Zhang Guozhong , Li Mingzhou , Zhang Shichao , Kang Huibin , Feng Wenfeng , Wang Gang 
Published: June 2024

Abstract

Objective
The aim of this research was to investigate the specific regulatory role of miR-6760-5p in angiogenesis in moyamoya disease.
Methods
HUVECs were transfected with miR-6760-5p inhibitor and mimics fragments, then subjected to assays for cell proliferation, migration, and tube formation. Subsequently, downstream target genes of miR-6760-5p were predicted and the protein expression levels of these genes were evaluated. The presence of miR-6760-5p and YAP1 was verified by a dual luciferase reporter gene test, followed by an assessment of the effects of YAP1 and miR-6760-5p on the HUVECs.
Results
Comparatively to the control group, increased expression of miR-6760-5p decreased cell growth, movement, and tube formation. YAP1 gene was discovered as a target controlled by miR-6760-5p, with subsequent investigation confirming YAP1 as a gene regulated by miR-6760-5p. Additionally, miR-6760-5p was found to counteract the angiogenesis-promoting effect of YAP1.
Conclusion
The results of this research suggest a possible link between the miR-6760-5p gene found in the cerebrospinal fluid of individuals with moyamoya disease and the process of vascularization in this particular condition. The findings indicate that miR-6760-5p may be a new molecular indicator and potential target for the diagnosis of moyamoya disease.