bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional connectivity of cortical motor areas in the resting state in Parkinson's disease
Authors: Wu Tao , Long Xiangyu , Wang Liang , Hallett Mark , Zang Yufeng , Li Kuncheng , Chan Piu 
Published: August 2010

AbstractParkinson's disease (PD) patients have difficulty in initiating movements. Previous studies have suggested that the abnormal brain activity may happen not only during performance of self‐initiated movements but also in the before movement (baseline or resting) state. In the current study, we investigated the functional connectivity of brain networks in the resting state in PD. We chose the rostral supplementary motor area (pre‐SMA) and bilateral primary motor cortex (M1) as “seed” regions, because the pre‐SMA is important in motor preparation, whereas the M1 is critical in motor execution. FMRIs were acquired in 18 patients and 18 matched controls. We found that in the resting state, the pattern of connectivity with both the pre‐SMA or the M1 was changed in PD. Connectivity with the pre‐SMA in patients with PD compared to normal subjects was increased connectivity to the right M1 and decreased to the left putamen, right insula, right premotor cortex, and left inferior parietal lobule. We only found stronger connectivity in the M1 with its own local region in patients with PD compared to controls. Our findings demonstrate that the interactions of brain networks are abnormal in PD in the resting state. There are more connectivity changes of networks related to motor preparation and initiation than to networks of motor execution in PD. We postulate that these disrupted connections indicate a lack of readiness for movement and may be partly responsible for difficulty in initiating movements in PD. Hum Brain Mapp, 2010. © 2010 Wiley‐Liss, Inc.
Amygdala and hippocampus volumetry and diffusivity in relation to dreaming
Authors: De Gennaro Luigi , Cipolli Carlo , Cherubini Andrea , Assogna Francesca , Cacciari Claudia , Marzano Cristina , Curcio Giuseppe , Ferrara Michele , Caltagirone Carlo , Spalletta Gianfranco 
Published: August 2010

AbstractMicrostructural analyses by MRI brain scans and by DTI analysis of MR images were used to investigate the possible relationship between deep gray matter structures (amygdala and hippocampus) and dreaming in healthy subjects. Thirty‐four subjects ranging in age 20s to 70s underwent to a MRI protocol for the assessment of volume and mean diffusivity (MD) in the amygdala and hippocampus and were asked to fill out a dream diary via audiotape recording upon morning awakening for two weeks. Multiple regression analyses evaluated the relationships between anatomical measures and quantitative and qualitative measures of the reported dreams. The main result points to a dissociation between some quantitative and qualitative aspects of dream reports. While the mean number of dreams recalled per day did not show any significant relationship with the neuroanatomical measures, significant associations with some qualitative features of the recalled dreams (emotional load, bizarreness, and vividness) and, to some extent, with the length of dream reports were observed. Particularly, a higher MD of the left amygdala, reflecting a decreased microstructural integrity, was associated with shorter dream reports and lower scores on emotional load. Bizarreness of dream reports was negatively correlated with the left amygdala volume and positively correlated with the right amygdala MD. Some specific, although weaker, relationships were also found between bizarreness and hippocampal measures. These findings indicate some direct relationships between volumetric and ultrastructural measures of the hippocampus‐amygdala complex and specific qualitative features of dreaming. Hum Brain Mapp, 2010. © 2010 Wiley‐Liss, Inc.
Regional gray matter density associated with emotional intelligence: Evidence from voxel‐based morphometry
Authors: Takeuchi Hikaru , Taki Yasuyuki , Sassa Yuko , Hashizume Hiroshi , Sekiguchi Atsushi , Fukushima Ai , Kawashima Ryuta 
Published: August 2010

AbstractEmotional Intelligence (EI) is the ability to monitor one's own and others' emotions and the ability to use the gathered information to guide one's thinking and action. EI is thought to be important for social life making it a popular subject of research. However, despite the existence of previous functional imaging studies on EI, the relationship between regional gray matter morphology and EI has never been investigated. We used voxel‐based morphometry (VBM) and a questionnaire (Emotional Intelligence Scale) to measure EI to identify the gray matter correlates of each factor of individual EI (Intrapersonal factor, Interpersonal factor, Situation Management factor). We found significant negative relationships between the Intrapersonal factor and regional gray matter density (rGMD) (1‐a) in an anatomical cluster that included the right anterior insula, (1‐b) in the right cerebellum, (1‐c) in an anatomical cluster that extends from the cuneus to the precuneus, (1‐d) and in an anatomical cluster that extends from the medial prefrontal cortex to the left lateral fronto‐polar cortex. We also found significant positive correlations between the Interpersonal factor and rGMD in the right superior temporal sulcus, and significant negative correlations between the Situation Management factor and rGMD in the ventromedial prefrontal cortex. These findings suggest that each factor of EI in healthy young people is related to the specific brain regions known to be involved in the networks of social cognition and self‐related recognition, and in the somatic marker circuitry. Hum Brain Mapp, 2010. © 2010 Wiley‐Liss, Inc.
Cognitive impairment in multiple sclerosis is associated to different patterns of gray matter atrophy according to clinical phenotype
Authors: Riccitelli Gianna , Rocca Maria A. , Pagani Elisabetta , Rodegher Maria E. , Rossi Paolo , Falini Andrea , Comi Giancarlo , Filippi Massimo 
Published: August 2010

AbstractObjective: To investigate whether cognitive impairment in multiple sclerosis (MS) patients is associated to different patterns of gray matter (GM) atrophy and T2‐visible lesion distribution according to the clinical phenotype. Experimental Design: Twenty‐two relapsing remitting (RR), 29 secondary progressive (SP), and 22 primary progressive (PP) MS patients, and 39 healthy controls underwent high‐field structural magnetic resonance imaging and an extensive neuropsychological battery. Voxel‐wise distribution of GM damage and T2‐lesions was compared between cognitively impaired (CI) and cognitively preserved (CP) patients according to their clinical phenotype. Principal Observations: Thirty‐nine MS patients were CI. In all MS groups, regional GM loss was correlated with cognitive impairment. Different patterns of regional distribution of GM atrophy and T2‐visible lesions were found between CI vs. CP MS patients, according to their clinical phenotype. No areas were significantly more atrophied in CI SPMS vs. CI RRMS patients. Conversely, compared with CI PPMS, CI SPMS patients had a significant GM loss in several regions of the fronto‐temporal lobes, the left hypothalamus and thalami. While in RRMS and SPMS patients there was a correspondence between presence of T2 visible lesions and GM atrophy in several areas, this was not the case in PPMS patients. Conclusion: Distinct patterns of regional distribution of GM damage and T2‐visible lesions are associated with cognitive impairment in MS patients with different clinical phenotypes. The correspondence between lesion formation and GM atrophy distribution varies in the different forms of MS. Hum Brain Mapp, 2010. © 2010 Wiley‐Liss, Inc.
1‐Heteroakylation of tris(trimethylsilyl)phosphine
Authors: Prishchenko Andrey A. , Livantsov Mikhail V. , Novikova Olga P. , Livantsova Ludmila I. , Petrosyan Valery S. 
Published: August 2010

AbstractThe 1‐heteroalkylation of the tris‐(trimethylsilyl)phosphine was thoroughly investigated using heterosubstituted methylamines, chloromethyl alkyl ethers, methyl chloroformate, paraformaldehyde, and dialkylformamides. Convenient methods for the synthesis of tris(dialkylaminomethyl)phosphines, tris(alkoxymethyl)phosphines, tris(methoxycarbonyl) phosphine, and several phosphaethylenes were proposed on the basis of the 1‐heteroalkylation of tris(trimethylsilyl)phosphine as a valuable synthon. © 2010 Wiley Periodicals, Inc. Heteroatom Chem 21:441–445, 2010; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.20636
Feasibility of submandibular gland preservation in neck dissection: A prospective anatomic‐pathologic study
Authors: Dhiwakar Muthuswamy , Ronen Ohad , Malone James , Rao Krishna , Bell Stephen , Phillips Roy , Shevlin Bruce , Robbins K. Thomas 
Published: August 2010

AbstractBackground.The submandibular gland is commonly removed during neck dissection involving sublevel IB. However, removal reduces basal salivary secretion and therapeutic options for minimizing xerostomia. The purpose of this study was to determine whether all lymph nodes in sublevel IB can be extirpated without removing the submandibular gland.Methods.Twenty consecutive patients undergoing 33 neck dissections were prospectively enrolled. Sublevel IB dissection was performed by 3 sequential steps: (1) removal of targeted lymph node groups (preglandular and postglandular, prevascular and postvascular), (2) removal of submandibular gland, and (3) removal of residual lymphoadipose tissue in the surgical bed.Results.Complete removal of lymph nodes in sublevel IB was achieved before excising the submandibular gland in all of the 30 eligible neck dissections. The submandibular gland and the surgical bed contained no residual lymph nodes.Conclusion.In suitable cases, it is technically feasible to remove all lymph nodes in sublevel IB and preserve the submandibular gland. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Contemporary management of sinonasal cancer
Authors: Robbins K. Thomas , Ferlito Alfio , Silver Carl E. , Takes Robert P. , Strojan Primoẑ , Snyderman Carl H. , de Bree Remco , Haigentz Missak , Langendijk Johannes A. , Rinaldo Alessandra , Shaha Ashok R. , Hanna Ehab Y. , Werner Jochen A. , Suárez Carlos 
Published: August 2010

AbstractBackground.Sinonasal cancer is a relatively uncommon entity encountered by head and neck oncologists, rhinologists, and skull base surgeons. Recent innovations in surgical and nonsurgical therapeutic modalities raise the question of whether there has been any measurable improvement for treatment outcomes.Methods.A retrospective review of data from recent studies that focus on surgery, radiation, and chemotherapy, or combinations thereof, was conducted.Results.Surgery continues to be the preferred treatment and provides the best results, albeit with an inherent bias based on patient selection. For advanced disease (T4 lesions), the survival rate remains only modest. Complications of treatment, including both surgical and radiation therapy, have been reduced.Conclusions.There is a need to improve the efficacy of treatment for this disease. Recommendations for the future direction of therapeutic investigations are outlined. © 2010 Wiley Periodicals, Inc. Head Neck, 2010
Long‐term survival of a patient with leptomeningeal involvement by nasopharyngeal carcinoma after treatment with high‐dose intravenous methotrexate
Authors: Fakhry Carole , Bajaj Gopal , Aygun Nafi , Westra William , Gillison Maura 
Published: August 2010

AbstractBackground.Nasopharyngeal carcinoma with leptomeningeal involvement is rare and typically has poor prognosis.Methods and Results.We present a case report of a patient with nasopharyngeal carcinoma who was treated with high‐dose intravenous methotrexate and remains asymptomatic and without clinical evidence of disease 6 years later.Conclusions.Systemic high‐dose methotrexate should be evaluated in the treatment of advanced nasopharyngeal carcinoma with central nervous involvement. © 2010 Wiley Periodicals, Inc. Head Neck, 2012
Classification of papillary thyroid microcarcinoma according to size and fine‐needle aspiration cytology: Behavior and therapeutic implications
Authors: Friguglietti Celso Ubirajara Moretto , Dutenhefner Simone Elisa , Brandão Lenine Garcia , Kulcsar Marco Aurélio Vamondes 
Published: August 2010

AbstractBackground.The purpose of this study was to assess and classify cases of papillary microcarcinoma according to size (up to 0.5 cm and between 0.6 and 1.0 cm) and fine‐needle aspiration cytology (FNAC). These results were then correlated with clinical and histopathologic factors of worse prognosis.Methods.A total of 448 cases of papillary thyroid carcinoma were studied retrospectively.Results.Of the 448 patients, 173 presented with carcinomas of ≤0.5 cm and 275 patients presented with carcinomas sized between 0.6 and 1.0 cm (>0.5 cm). Lymph node metastasis was diagnosed in 6% of the carcinoma cases of ≤0.5 cm and in 16% of the cases with tumors of >0.5 cm. A total of 281 cases tested positive for papillary carcinoma by FNAC, and in 113 cases, the carcinoma was diagnosed during the histopathologic examination. A positive FNAC for carcinoma was correlated with a higher incidence of lymph node metastasis (16% vs 5%).Conclusion.The diagnosis of papillary carcinoma using the preoperative biopsy enables a more precise oncological procedure with greater chance of biological cure. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Aspiration after supracricoid partial laryngectomy: Incidence, risk factors, management, and outcomes
Authors: Benito José , Holsinger F. Christopher , Pérez‐Martín Augustin , Garcia Dominique , Weinstein Gregory S. , Laccourreye Ollivier 
Published: August 2010

AbstractBackground.The aim of this study was to evaluate the incidence, risk factors, management, and outcome of postoperative aspiration in patients managed with a supracricoid partial laryngectomy (SCPL) for selected invasive squamous carcinoma of the larynx.Methods.In all, 457 patients underwent SCPL at an academic, tertiary referral care center, 1975–2000. The incidence of aspiration defined in accord with Pearson's scale was recorded. Univariate and multivariate analyses were performed for potential statistical relation with various variables. The management and outcome of aspiration are presented.Results.Normal swallowing without aspiration was noted in 259 patients (58.9%). Grades 1, 2, and 3 aspiration occurred in 87, 48, and 53 patients (19%, 10.5%, and 11.6%), respectively. A significant relationship was noted between aspiration and increased age, performing cricohyoidopexy, not repositioning the pyriform sinuses, and resecting an arytenoid cartilage. A prediction model, based on multinomial logistic regression, found that the probability that severe aspiration cases (grade 2–3) exceeded the subclinical ones (grade 0–1) occurred only when a cricohyoidopexy with partial or total arytenoid resection was performed in patients >70 years of age (p = .0000001). Management of aspiration required a temporary gastrostomy, a permanent gastrostomy, and a completion total laryngectomy in 65, 3, and 7 of 188 patients (34.5%, 1.6%, and 3.7%, respectively) who aspirated, and 65, 3, and 7 of 457 of the entire population (14.2%, 0.6%, and 1.5%, respectively). Aspiration‐related death was not encountered in the current series.Conclusions.Aspiration after SCPL is a common but rarely severe event, with a low incidence for permanent gastrostomy or completion laryngectomy. Aspiration can be minimized with careful patient selection and precise surgical technique. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Retropharyngeal lymph node metastases in head and neck malignancies
Authors: Coskun H. Hakan , Ferlito Alfio , Medina Jesus E. , Robbins K. Thomas , Rodrigo Juan P. , Strojan Primož , Suárez Carlos , Takes Robert P. , Woolgar Julia A. , Shaha Ashok R. , de Bree Remco , Rinaldo Alessandra , Silver Carl E. 
Published: August 2010

AbstractRetropharyngeal lymph node (RPLN) metastasis of primary head and neck cancer often receives less consideration than lymph node metastasis in the neck. With improvements in imaging techniques and reports of surgical pathology, there is an improved understanding of the risk and subsequently the need for treatment of RPLNs. The rates of RPLN metastasis from carcinomas of the nasopharynx, oropharynx, hypopharynx, postcricoid region, maxillary sinus, and cervical esophagus are sufficiently high to warrant routine treatment, either electively or therapeutically, of this region. Through improved diagnostic techniques and heightened awareness of RPLN metastasis, patients at risk of having these metastases can be treated more effectively. © 2010 Wiley Periodicals, Inc. Head Neck, 2010
Clinicopathological aspects of mucosa‐associated lymphoid tissue (MALT) lymphoma of the parotid gland: A retrospective single‐center analysis of 28 cases
Authors: Troch Marlene , Formanek Michael , Streubel Berthold , Müllauer Leonhard , Chott Andreas , Raderer Markus 
Published: August 2010

AbstractBackground.In constrast to its gastric counterpart, mucosa‐associated lymphoid tissue (MALT) lymphoma of the parotid gland has not been studied extensively. We analyzed the clinicopathological features and the clinical course of all patients with parotid gland MALT lymphoma diagnosed and treated at our institution.Methods.Patient characteristics including an underlying autoimmune disease, disease stage, genetic aberrations, treatment, and clinical course were assessed and evaluated. Twenty‐eight patients (19 women, 9 men) were identified; median age at diagnosis was 49 years (interquartile range [IQR], 40–56), and 18 patients (64%) had an underlying autoimmune disease. Eleven had stage IE, 7 patients had stage IIE, and 10 had advanced disease (stage IV).Results.Genetic aberrations were detected in 9 of 20 patients; 5 patients had trisomy 3, 2 patients had a t(11;18)(q21;21) translocation, 1 had trisomy 3 and 18, and 1 patient had a t(14;18)(q32;q21) translocation plus trisomy 18. After a median follow‐up time of 62 months (IQR, 32–98 months), 24 patients (86%) are alive. Fifteen patients are free from lymphoma, whereas 13 patients (46%) have had a relapse.Conclusion.Our data suggest that MALT lymphoma of the parotid gland is often associated with autoimmune diseases and that trisomy 3 is the most common genetic feature of this disease. The high rate of relapse warrants further study on optimal therapy of such patients. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Osteolipoma of the parapharyngeal space mimicking liposarcoma: A case report
Authors: Bulkeley William , Mills Omie L. , Gonzalvo Americo , Wong Kondi 
Published: August 2010

AbstractBackground.Lipomas are the most common benign neoplasm of the head and neck. However, osteolipomas, a rare variant of lipoma, are uncommon in this location. When they occur, variations in location and radiographic presentation may obscure the diagnosis.Methods and Results.A 68‐year‐old man presented with left jaw pain and numbness in the maxillary (V‐1) distribution. A CT angiography of the neck revealed a possible liposarcoma. Embolization of the mass was determined to be unfeasible. Consequently, surgical resection was performed revealing a benign osteolipoma.Conclusion.We report a rare case of osteolipoma of the parapharyngeal space. Clinicians should be aware that the clinical and radiological features of patients with head and neck osteolipomas may mimic malignant neoplasms. When given deserved consideration, inappropriate treatment of an otherwise benign lesion may be avoided. © 2010 Wiley Periodicals, Inc. Head Neck, 2012
Tumor growth inhibition of metastatic nasopharyngeal carcinoma cell lines by low dose of arsenic trioxide via alteration of cell cycle progression and induction of apoptosis
Authors: Yeh Kun‐Yun , Chang John W.‐C. , Li Ying‐Ying , Wang Cheng‐Hsu , Wang Hung‐Ming 
Published: August 2010

AbstractBackground.Although arsenic trioxide (ATO) has displayed anticancer activity against primary nasopharyngeal carcinoma (NPC), its efficacy in metastatic NPC deserved further investigation because the biological/therapeutic difference in cancer cells probably exists between primary and distant sites.Methods.Two human metastatic NPC cell lines (NPC‐BM1 and NPC‐BM2) were investigated. We measured cellular proliferation, cell cycle, and apoptotic extent of BM1 and BM2 cells treated with ATO in vitro. Furthermore, we evaluated the tumor growth after ATO treatment in vivo.Results.Low‐dose ATO treatment is sufficient to induce an antiproliferative effect, alter the cell cycle, and increase apoptosis in BM1 and BM2 cells. BM1 tumor growth in a xenograft model with low‐dose and short‐schedule (1 mg/kg/day, intraperitoneal injection for 5 consecutive days) of ATO treatment significantly slowed in vivo.Conclusion.ATO at low dose seems to be an encouraging schedule for palliative treatment of metastatic NPC. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Neck dissections in the United States from 2000 to 2006: Volume, indications, and regionalization
Authors: Kim Eugene Y. , Eisele David W. , Goldberg Andrew N. , Maselli Judy , Kezirian Eric J. 
Published: August 2010

AbstractBackground.The purpose of this study was to examine trends in neck dissection and regionalization.Methods.This cross‐sectional and longitudinal study used the years 2000, 2004, and 2006 data from the Nationwide Inpatient Sample. Chi‐square tests compared trends for total neck dissections and specific subsites. To test regionalization, we examined the distribution of procedures across hospital and procedure volume quartiles.Results.From 2000 to 2006, the number of neck dissections increased from 18,112 to 22,918. Three‐fourths of the total increase was associated with thyroid and parathyroid gland or skin neoplasms. There was an increase in neck dissections for upper aerodigestive tract (UADT) subsites and no decline for the oropharynx and tongue base. Regionalization occurred as high‐volume hospitals and providers performed a greater proportion of neck dissections over time.Conclusion.Neck dissections increased from the year 2000 to 2006. There were no decreases in neck dissections for certain subsites with a greater role for primary chemoradiotherapy. Regionalization has occurred. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
CT cross‐sectional imaging classification system for substernal goiter based on risk factors for an extracervical surgical approach
Authors: Mercante Giuseppe , Gabrielli Enrico , Pedroni Corrado , Formisano Debora , Bertolini Laura , Nicoli Franco , Valcavi Roberto , Barbieri Verter 
Published: August 2010

AbstractBackgroundThe purpose of this study was to identify risk factors for surgical extracervical approach in patients with substernal goiter. We used a novel classification system based on CT scan cross‐sectional imaging (CSI) reconstruction.MethodsMedical records of 4297 patients with thyroid disease operated on at our department were reviewed. A CSI classification system defined substernal goiter in the cranio‐caudal dimension as: grade 1 (above aortic arch), grade 2 (level of aortic arch), and grade 3 (below aortic arch); in the anteroposterior dimension as type A (prevascular), type B (retrovascular‐paratracheal), and type C (retrotracheal); in the latero‐lateral dimension as: monolateral or bilateral.ResultsThe prevalence of substernal goiter was 222 of 4297 cases (5.1%). Fifteen of 222 cases (6.7%) required an extracervical approach due to grade ≥2 and/or type C substernal goiter (14 of 15 cases). Ten of 15 patients had malignancy.ConclusionThe CT‐CSI classification system allows us to identify risk factors for extracervical surgical approach in substernal goiter. They are grade ≥2, type C substernal goiter, and malignancy. © 2010 Wiley Periodicals, Inc. Head Neck, 2011