bluuebunny/crossref_metadata_2025_split huggingface dataset:
Positive impacts of Nannochloropsis oculata supplementation on gene expression of immune and antioxidant markers and metabolic profile of Barki sheep in the transition period and lipogenic effects on progeny
Authors: El-Sayed Ahmed , Ebissy Eman , Ateya Ahmed 
Published: May 2024

AbstractNannochloropsis species should be given priority when it comes to microalgae that should be added to feed since they are suitable for intense culture and have a high concentration of PUFAs (especially EPA), antioxidants, and certain vitamins. This study investigated the possible immune and antioxidant impacts of Nannochloropsis supplementation on Barki ewes during transition period and their newly born lambs. Three weeks prior to the expected time of lambing, the researched ewes were divided into two equal groups of thirty ewes each. The second group, on the other hand, was fed the same base diet as the first group plus 10 g of commercially available Nannochloropsis powder per kg of concentrate, given daily to each ewe’s concentrate. Findings revealed that supplementation of ewes with Nannochloropsis significantly up-regulated the expression pattern of immune (NFKB, RANTES, HMGB1, TNF-α, IRF4, TLR7, CLA-DRB3.2, IL1B, IL6, CXCL8, S-LZ, and Cathelicidin), and antioxidant (SOD1, CAT, GPX1, GST, ATOX1, Nrf2 and AhpC/TSA) markers in ewes post-lambing and their newly born lambs. Additionally, mRNA levels of lipogenic (ACACA, FASN SCD, LPL, and BTN1A) markers were significantly up-regulated in lambs from supplemented ewes than control ones. There was a significant increase in the WBCs, Hb, RBc count, serum level of glucose, total protein, triacylglycerol and total cholesterol, GPx, catalase, IL1α and IL6 with significantly decreased serum level of TNF-α and MDA in supplemented ewes after lambing as compared with control ones. There was also a significant increase in WBCs, Hb, RBc count, birth weight and body temperature with significantly decreased in the serum levels of TNF-α and stillbirth of newly born lambs from supplemented ewes as compared to other lambs from control ones.
The Michaelis–Menten Reaction at Low Substrate Concentrations: Pseudo-First-Order Kinetics and Conditions for Timescale Separation
Authors: Eilertsen Justin , Schnell Santiago , Walcher Sebastian 
Published: May 2024

AbstractWe demonstrate that the Michaelis–Menten reaction mechanism can be accurately approximated by a linear system when the initial substrate concentration is low. This leads to pseudo-first-order kinetics, simplifying mathematical calculations and experimental analysis. Our proof utilizes a monotonicity property of the system and Kamke’s comparison theorem. This linear approximation yields a closed-form solution, enabling accurate modeling and estimation of reaction rate constants even without timescale separation. Building on prior work, we establish that the sufficient condition for the validity of this approximation is $$s_0 \ll K$$

s
0

≪
K

, where $$K=k_2/k_1$$

K
=

k
2

/

k
1

is the Van Slyke–Cullen constant. This condition is independent of the initial enzyme concentration. Further, we investigate timescale separation within the linear system, identifying necessary and sufficient conditions and deriving the corresponding reduced one-dimensional equations.
Neuroprotective Role of Selenium Nanoparticles Against Behavioral, Neurobiochemical and Histological Alterations in Rats Subjected to Chronic Restraint Stress
Authors: Elfakharany Sarah A. , Eskaros Samir S. , Azhary Nesrine M. El , Abdelmonsif Doaa A. , Zeitoun Teshreen M. , Ammar Gamal A. G. , Hatem Youssef A. 
Published: May 2024

AbstractChronic stress induces changes in the prefrontal cortex and hippocampus. Selenium nanoparticles (SeNPs) showed promising results in several neurological animal models. The implementation of SeNPs in chronic restraint stress (CRS) remains to be elucidated. This study was done to determine the possible protective effects of selenium nanoparticles on behavioral changes and brain oxidative stress markers in a rat model of CRS. 50 rats were divided into three groups; control group (n = 10), untreated CRS group (n = 10) and CRS-SeNPs treated group (n = 30). Restraint stress was performed 6 h./day for 21 days. Rats of CRS-SeNPs treated group received 1, 2.5 or 5 mg/kg SeNPs (10 rats each) by oral gavage for 21 days. Rats were subjected to behavioral assessments and then sacrificed for biochemical and histological analysis of the prefrontal cortex and hippocampus. Prefrontal cortical and hippocampal serotonin levels, oxidative stress markers including malondialdehyde (MDA), reduced glutathione (GSH) and glutathione peroxidase (GPx), tumor necrosis factor alpha (TNF-α) and caspase-3 were assessed. Accordingly, different doses of SeNPs showed variable effectiveness in ameliorating disease parameters, with 2.5 mg/kg dose of SeNPs showing the best improving results in all studied parameters. The present study exhibited the neuroprotective role of SeNPs in rats subjected to CRS and proposed their antioxidant, anti-inflammatory and anti-apoptotic effects as the possible mechanism for increased prefrontal cortical and hippocampal serotonin level, ameliorated anxiety-like and depressive-like behaviors and improved prefrontal cortical and hippocampal histological architecture.
Dimensional and Structural Instability of Electrospun Polylactic Acid Membranes in Liquid Environments: Role of Water, Ethanol, and Temperature
Authors: Hambleton Annaliese Rebecca , Mele Elisa 
Published: May 2024

AbstractElectrospun nanofibres of polylactic acid (PLA) are suggested for a variety of uses, including scaffolds for tissue engineering, components of drug delivery devices, sustainable packaging materials and membranes for liquid filtration/purification. For all these applications, it is critical to consider the stability of the PLA electrospun materials once in operation. Exposure to certain liquids and temperatures can modify their dimensions, shape, surface topography and mechanical response and compromise their performance. In this study, electrospun PLA mats were exposed to water and ethanol solutions, at different temperatures and for defined time periods, and changes in their properties were analysed. It was found that the impact of water on area shrinkage and fibre arrangement strongly depended on temperature, particularly if the treatment was performed at the glass transition temperature of PLA. Ethanol, instead, induced significant alterations in the size, morphology, and elastic modulus of the electrospun mats, even at room temperature and determined the formation of crimped structures. This work provides insights into the conditions that can critically affect the properties of PLA electrospun fibres and, hence, impact on their usage.
Local Watershed Properties Cannot Explain Divergent Dynamics of Pacific Herring in an Urbanizing Estuary
Authors: Davis Leah R. , Urfer Fabienne , Essington Timothy E. , Feist Blake E. , Francis Tessa B. 
Published: May 2024

AbstractPacific herring (Clupea pallasii) is a foundational species in Puget Sound (Washington State, U.S.A.) and is subject to many anthropogenic threats. We assessed the overall status of the Puget Sound Pacific herring sub-stock complex and asked whether watersheds with less urban or agricultural land cover, less impervious surface, and lower human density were associated with better stock status. To this end, we developed multiple metrics of sub-stock population status; characterized watershed properties with respect to land use/land cover, percent impervious surfaces, and human density; and used statistical model selection to evaluate the weight of evidence in support of our hypotheses. Overall, the status of sub-stocks was poor; metrics for most sub-stocks indicate a decline from 1996–2021. However, the status metrics of sub-stocks were not related to recent (2016) watershed characteristics or the rate of change in watershed characteristics from the mid-1990s to 2016. While the cumulative effects of local human land use throughout Puget Sound may be contributing to the deterioration of spawning biomass, these results also suggest that other drivers that operate at larger scales (e.g., predation, disease, climate) are likely important.
Digital contact tracing technology in the COVID-19 pandemic: a systematic review
Authors: Irwin Nicole , Aisyah Dewi Nur , Rahman Fauziah Mauly , Manikam Logan 
Published: May 2024

Abstract
Introduction
The COVID-19 pandemic prompted public health teams across the world to emphasize case identification, contact tracing, and isolation in outbreak management strategies. Contact tracing was advanced by global access to mobile phones to develop and implement digital contact tracing (DCT) technology with the objective of increasing the rate of contact tracing while reducing the resources required.

Purpose
This study aimed to describe the DCT technology used during the COVID-19 pandemic across the world, and to identify differences and similarities between characteristics and uses.

Methods
This review followed the PRISMA (2020) guidelines for systematic reviews. Literature searches were conducted using Embase, MEDLINE, and PubMed and were restricted to English studies published between 2019 to 2023. Studies were excluded if they did not report findings for DCT during COVID-19, did not provide data for technology characteristics or outcomes, or were a study design listed for exclusion.

Results
Sixty one studies were included in the review producing results for 147 digital contact tracing technologies across 83 countries. The majority of digital contact tracing (DCT) technologies are government-owned (75.6%), primarily developed for COVID-19 tracing (96.4%). Bluetooth is the most favored technology (70%) used in their development, followed by GPS (30%) and QR codes (22%). Applications are the preferred platform (90.9%), with a few using applets (6.3%) and wearable devices (1.4%). Only 2 DCT technologies have achieved over 100 million downloads or uses (3.1%). Most DCTs fall into the 1–9.99 million downloads range (27.7%) and 10,000–99,999 downloads (20%). The majority of DCTs are voluntarily used by the population (63.6%), while 27.3% are mandated for use.

Conclusions
Digital contact tracing technologies were developed and implemented globally as a strategy in emergency outbreak management to reduce the spread of disease. This review describes the use of DCT across the world by identifying key features and characteristics that will serve as a lesson learned for improvement of existing DCT technologies for other emergency response outbreak management.
Research on the factors influencing the width of hydraulic fractures through layers
Authors: Liang Yunpei , Wang Mao , Luo Yongjiang , Rui Tao , Wang Xing , Meng Yu 
Published: May 2024

AbstractThe method of segmented hydraulic fracturing in the coal seam roof has proven to be an efficient technique for coalbed methane exploitation. However, the behavior of hydraulic fractures in multilayer formations with significant differences in mechanical properties is still unclear. This paper studied the variation in hydraulic fracture width at the coal-rock interface by employing experimental method with a true triaxial hydraulic fracturing experimental system and numerical simulation method. Results revealed that the hydraulic fracture more likely to expanded along the coal-rock interface instead of break through it with the small horizontal stress difference and low flow rate injection condition. And improving the injection flow rate lager than a critical value, the hydraulic fracture tends to break through the coal-rock interface. Hydraulic fractures in both mudstone and coal beds exhibited a trend of increasing and then decreasing of fracture width at the interface. Since the strength of the coal seam was lower compared to that of the mudstone, maintaining high pressure was no longer necessary when the hydraulic fracture crossed the interface and entered the coal seam, leading to a reduction in fracture width within the mudstone. During the later stages of fracturing, the entry of proppant into the coal seam became challenging, resulting in a phenomenon characterized by excessive fluid but insufficient sand. The time required for the fracture width to traverse the proppant was found to be inversely proportional to the difference in horizontal ground stress and the flow rate of the fracturing fluid. And it was directly proportional to the modulus of elasticity, permeability of the coal seam, and interface strength. The interface strength has the greatest influence on the width of hydraulic fractures. In conclusion, this study provides valuable insights into the behavior of hydraulic fractures in multilayer formations with varying mechanical properties. The findings contribute to a better understanding of the factors affecting hydraulic fracture width within coal seams, which can ultimately enhance the efficiency of coalbed methane exploitation.
Assessment of demand consumptions and potential viability of installation of biogas digester in melani village Eastern Cape, South Africa
Authors: Mthimunye Thabiso Vincent , Mukumba Patrick , Makaka Golden 
Published: May 2024

AbstractAfrica relies heavily on traditional fossil fuel sources, especially coal. To solve the energy problem in rural areas, the country initiated the production and distribution of several renewable energy technologies. Biogas has been proven viable and has begun as a promising technology among several promising technologies. It has been one of the most successful models for producing clean, environmentally friendly, cost-effective energy sources and has multiple benefits. A financial analysis will be conducted, including an estimation of the total investment, the present value of the annual investment, the present value of the investment, and a simple payback period. To determine the demand, onset CTA-A hobo current transducers were installed in three families to measure everyday use in summer and winter. The Data acquisition system has shown that each home consumes an average of 140 kWh of electricity per month. Finally, the biogas digester's analytical life cycle cost analysis shows that the simple payback period would be approximately two years.
Defining Mechanistic Pathways for Anthropogenic Noise Impact on Avian Species
Authors: Engel Margret S. , Young Robert J. , Davies William J. , Waddington David , Wood Michael D. 
Published: May 2024

Abstract
Purpose of Review
This review collates and analyses data on noise exposure of birds in relation to avian hearing system performance. It provides new insights into the mechanistic pathways of anthropogenic noise impact on avian species.

Recent Findings
Noise impacts both humans and wildlife. Birds are of conservation concern, given the recent reports of major global declines in bird populations and that one in eight bird species is threatened with extinction. Studies of noise impacts on birds have been, and continue to be, published. Whilst many of these studies report associations between noise and a response in birds, relatively few provide clear demonstration of the mechanisms of impact.

Summary
Anatomical and physiological datasets were compiled for species representing nineteen avian orders. Information on noise sources, propagation path and habitat selection was also collated. Bird order was not a good predictor of bird hearing frequencies, but body dimensions were. In general, smaller birds were found to have higher peak hearing frequencies than larger birds. Cranium height was the strongest predictor of peak hearing frequency for birds. These findings provide mechanistic context to noise impacts on birds and a potential basis for predicting responses of avian species to different noise environments.
Relational Skills and Corporate Productivity in a Comparative Size Class Perspective
Authors: Becchetti Leonardo , Mancini Sara , Solferino Nazaria 
Published: May 2024

AbstractDrawing on insights from various fields within game theory literature, such as strategic interactions, social dilemmas, gift exchange, and procedural utility, we argue that corporate social responsibility (CSR) and relational skills—whether between firms, employers and workers, among workers themselves, or with stakeholders—are associated with positive effects on productivity. We test this hypothesis using a comparative approach across small, medium, and large Italian firms, leveraging data from the 2019 CSR survey conducted by the Italian Statistical Institute (ISTAT). Our analysis reveals that firm size plays a crucial role in the impact of relational skills on added value per worker, even after controlling for relevant factors. Key components of relational skills identified in our study include corporate policies focusing on workers' well-being, prioritizing teamwork attitudes in recruitment, supporting initiatives within the local productive network, and involving stakeholders in CSR initiatives. Our findings indicate that stakeholder engagement positively impacts all firm sizes, while worker well-being is particularly significant for small and medium firms, local network initiatives for medium and large firms, and teamwork for medium-sized firms. Instrumental variable estimates find evidence of a causal link beyond these correlations. We conclude that firm size exhibits an inverse U-shaped effect on the impact of teamwork skills, reduces the influence of gift exchange mechanisms, and strengthens the effects of investments in the local productive environment on added value per worker.
Homology and Euler characteristic of generalized anchored configuration spaces of graphs
Authors: Kozlov Dmitry N. 
Published: May 2024

AbstractIn this paper we consider the generalized anchored configuration spaces on n labeled points on a graph. These are the spaces of all configurations of n points on a fixed graph G, subject to the condition that at least q vertices in some pre-determined set K of vertices of G are included in each configuration. We give a non-alternating formula for the Euler characteristic of such spaces for arbitrary connected graphs, which are not trees. Furthermore, we completely determine the homology groups of the generalized anchored configuration spaces of n points on a circle graph.
The improved residual power series method for the solutions of higher-order linear and nonlinear boundary value problems
Authors: Gillani Rimshah , Dawar Abdullah , Khan Hamid 
Published: May 2024

Abstract
IRPSM is the extended form of RPSM that gives an approximate solution to boundary value problems without requiring an exact solution. This method creates a truncated series for the determination of the missing initial conditions. The present study is conducted to evaluate semi-numerical solutions to differential equations using the Improved Residual Power Series Method (IRPSM). Our main objective is to check whether the proposed scheme is efficient for solving such equations or not. The solution of differential equations has been approximated using truncated residual power series. The method is used to solve differential equations for higher-order linear and non-linear boundary value problems. Absolute errors for the solved problems are calculated to ensure accuracy. It is also compared with some known methods, like the Differential Transform Method (DTM) and the Homotopy Perturbation Method (HPM). For the calculations, Mathematica 12.0 software is used. The computed results are compared to the exact solutions as well as the available results in the literature. The results showed that the results obtained by IRPSM are closely related to the exact solution when compared to the DTM and HPM results.
Ancient Craton‐Wide Mid‐Lithosphere Discontinuity Controlled by Pargasite Channels
Authors: Sudholz Z. J. , Zhang P. , Eakin C. M. , Yaxley G. M. , Jaques A. L. , Frigo C. , Czarnota K. 
Published: May 2024

AbstractThe mechanisms governing a commonly observed seismic velocity drop in the cratonic lithosphere, referred to as the mid‐lithospheric discontinuity (MLD), have been widely debated. To identify the composition and seismic structure of MLDs, we have analyzed Sp receiver functions (SRF) and mantle xenocrysts for six regions across Australia. We utilize locations where seismic stations and kimberlite‐hosted mantle xenocrysts are both available, allowing for comparison between seismological and petrological constraints. Our results show negative SRF phases indicative of the MLD coincide with clinopyroxene‐depleted zones at 60–140 km depth. Clinopyroxenes with different chemical compositions across the MLD define a litho‐chemical discontinuity. Modeling and experimental data show that MLDs may be explained by modified lherzolite with 10%–20% modal pargasite. Pargasite MLDs may form when rising H2O‐bearing melts cross the amphibole dehydration curve and react with clinopyroxene in lherzolite. Because the amphibole dehydration curve is isobaric at 80–120 km, pargasite will be precipitated as horizontal channels.
Anterior cingulate cortex-related functional hyperconnectivity underlies sensory hypersensitivity in Grin2b-mutant mice
Authors: Lee Soowon , Jung Won Beom , Moon Heera , Im Geun Ho , Noh Young Woo , Shin Wangyong , Kim Yong Gyu , Yi Jee Hyun , Hong Seok Jun , Jung Yongwhan , Ahn Sunjoo , Kim Seong-Gi , Kim Eunjoon 
Published: May 2024

AbstractSensory abnormalities are observed in ~90% of individuals with autism spectrum disorders (ASD), but the underlying mechanisms are poorly understood. GluN2B, an NMDA receptor subunit that regulates long-term depression and circuit refinement during brain development, has been strongly implicated in ASD, but whether GRIN2B mutations lead to sensory abnormalities remains unclear. Here, we report that Grin2b-mutant mice show behavioral sensory hypersensitivity and brain hyperconnectivity associated with the anterior cingulate cortex (ACC). Grin2b-mutant mice with a patient-derived C456Y mutation (Grin2bC456Y/+) show sensory hypersensitivity to mechanical, thermal, and electrical stimuli through supraspinal mechanisms. c-fos and functional magnetic resonance imaging indicate that the ACC is hyperactive and hyperconnected with other brain regions under baseline and stimulation conditions. ACC pyramidal neurons show increased excitatory synaptic transmission. Chemogenetic inhibition of ACC pyramidal neurons normalizes ACC hyperconnectivity and sensory hypersensitivity. These results suggest that GluN2B critically regulates ASD-related cortical connectivity and sensory brain functions.