bluuebunny/crossref_metadata_2025_split huggingface dataset:
Direct Monitoring of Whole‐Brain Electrodynamics via High‐Spatiotemporal‐Resolution Photoacoustics with Voltage‐Sensitive Dye
Authors: Pang Weiran , Zhu Bowen , Li Honghui , Zhou Yingying , Woo Chi Man , Huang Xiazi , Zhong Tianting , Lo Hsuan , Wang Laiyou , Lai Puxiang , Nie Liming 
Published: May 2024

AbstractBrain voltage plays a crucial role in indicating internal functions or diseases, and optical voltage imaging has gained intensive attention in recent years. Despite encouraging progress, current implementations encounter limitations pertaining to penetration depth, field of view (FOV), and photostability of indicators. To mitigate these challenges, a robust voltage‐sensitive dye (VSD)‐based whole‐field photoacoustic brain detection (WF‐PABD) platform is proposed, enabling direct evaluation of voltage dynamics across the whole brain, forming as PA‐VSD. WF‐PABD is equipped with a 512‐element ring‐array ultrasound detector capable of 360‐degree scanning, providing a large FOV (≈5 cm), high spatial resolution (≈110 µm), and rapid imaging acquisition. The proposed VSD remained ≈75% photostability after 30 min laser exposure, much greater than most calcium sensors. The optical voltage‐response mechanisms are validated and the capability of PA‐VSD to directly screen seizures is established. It is demonstrated that investigating connectivity among different brain regions allows to identify the precise location of active epileptic foci as well as the electrical conduction pathways and their directionality through fast temporal visualization. In summary, this study not only addresses the need for non‐invasive, high‐resolution, long‐term, and direct monitoring of brain voltage but also empowers exciting venues for PA applications in neuroscience.
Liquid Nitrogen Temperature Multicolor Persistent Luminescence in a Single Host Material
Authors: Li Jiacai , Zhang Xiaomin , Yu Ruoxi , Chen Chao , Zhang Chennan , Li Mingxing , Pan Gencai , Zhang Huafang , Gao Huiping , You Wenwu , Mao Yanli 
Published: May 2024

AbstractPersistent luminescence (PersL) phosphors have garnered significant attention for their extensive applications in various fields. It is regrettable that these PersL phosphors typically possess deep traps. At low temperatures (LT), energy stored in the trap cannot be released to the luminescent centers through thermal de‐trapping, thereby causing these PersL phosphors to lose their PersL characteristics in LT. Currently, there is little research on LT PersL phosphors, and multicolor LT PersL in a single host material has not been reported. In this work, multicolor LT PersL is achieved in a single host material by modifying the emission center. Remarkably, an ultra‐shallow trap with a depth of 0.23 eV is discovered in the Cs2NaLuCl6:5%Ln3+ phosphors, which is essential for achieving PersL at 77 K. First‐principles calculations indicate that the ultra‐shallow trap in Cs2NaLuCl6:5%Ln3+ is caused by the distortion of [NaCl6] octahedron in the phosphors. These findings provide new perspectives into X‐ray‐induced trap generation and offer valuable insights for designing multicolor PersL phosphors for LT applications.
A construal level account of when consumers prefer to spend loyalty points over money
Authors: Bagga Charan K. , Nastasoiu Alina , Bendle Neil T. , Vandenbosch Mark 
Published: May 2024

AbstractThe central questions answered in this research are, “For what, and when, do consumers prefer to spend loyalty points over money?” We use construal level theory (CLT) to theorize that loyalty (or reward) points are perceived abstractly while money is perceived concretely, and this impacts spending preferences. We find that consumers prefer to spend loyalty points (vs. money) on high desirability‐low feasibility (vs. low desirability‐high feasibility) consumption items. The same pattern also persists when the items that vary on desirability and feasibility are equivalently priced. Second, we show that the construal‐level matching phenomenon influences temporal decisions such that consumers prefer to spend points (vs. money) for items that are available later (vs. now). Third, the moderating effect of category type (experiential vs. material) is reported. Finally, we demonstrate two managerial applications that are reported in the Web Appendix. We show that managers may influence how consumers spend loyalty points (a) by altering the concreteness of the decision context, and (b) by manipulating the nature of loyalty points.
LDHA‐mediated M2‐type macrophage polarization via tumor‐derived exosomal EPHA2 promotes renal cell carcinoma progression
Authors: Gan Xinxin , Hu Jiatao , Pang Qingyang , Yan Rui , Bao Yi , Liu Ying , Song Jiaao , Wang Zheng , Sun Weihao , Huang Fuzhao , Cai Chen , Wang Linhui 
Published: May 2024

AbstractLactate dehydrogenase A (LDHA) is known to promote the growth and invasion of various types of tumors, affects tumor resistance, and is associated with tumor immune escape. But how LDHA reshapes the tumor microenvironment and promotes the progression of renal cell carcinoma (RCC) remains unclear. In this study, we found that LDHA was highly expressed in clear cell RCC (ccRCC), and this high expression was associated with macrophage infiltration, while macrophages were highly infiltrated in ccRCC, affecting patient prognosis via M2‐type polarization. Our in vivo and in vitro experiments demonstrated that LDHA and M2‐type macrophages could enhance the proliferation, invasion, and migration abilities of ccRCC cells. Mechanistically, high expression of LDHA in ccRCC cells upregulated the expression of EPHA2 in exosomes derived from renal cancer. Exosomal EPHA2 promoted M2‐type polarization of macrophages by promoting activation of the PI3K/AKT/mTOR pathway in macrophages, thereby promoting the progression of ccRCC. All these findings suggest that EPHA2 may prove to be a potential therapeutic target for advanced RCC.
Upregulation of collagen type X alpha 1 promotes the progress of triple‐negative breast cancer via Wnt/β‐catenin signaling
Authors: Peng Jing , Liu Xiangping , Mao Yan , Lv Meng , Ma Teng , Liu Jiaxiu , Zhou Quan , Han Yafei , Li Xin , Wang Haibo 
Published: May 2024

AbstractTriple‐negative breast cancer (TNBC) is a malignant tumor with high degree of malignancy and lack of effective target treatment. The research aims to explore the role and mechanism of X collagen alpha‐1 chain protein (COL10A1 gene) in TNBC. UALCAN and Kaplan–Meier were used to detect the expression of COL10A1 and its role in the prognosis of breast cancer patients. The cells with stably expressing high levels of COL10A1 were obtained by recombinant lentivirus infection. The expression of COL10A1 in cells was temporarily downregulated by siRNA interference fragments. Real‐time quantitative polymerase chain reaction and western blot analysis were utilized to detect the changes of COL10A1 mRNA and protein expression. The biological functions of the cells were evaluated by colony formation, cell counting kit‐8, cell invasion and wound healing experiments. In addition, the effect of COL10A1 on angiogenesis was investigated by tube formation assay. Xenograft tumor model was used to confirm the effect of COL10A1 on tumorigenicity in vivo and multiplex fluorescent immunohistochemistry to detect multiple proteins simultaneously. The possible molecular mechanism of the function of COL10A1 was speculated through the detection of proteins in functionally related pathways. COL10A1 is highly expressed and is significantly associated with worse overall survival (OS) and recurrence‐free survival (RFS) in TNBC. Overexpression of COL10A1 increased the clone formation rate and cell migration capacity of TNBC cells. In the COL10A1 overexpression group, the clone formation rates of MD‐MB‐231 and BT‐549 cells (21.5 ± 0.62, 27.83 ± 3.72)% were significantly higher than those in the control group(15.23 ± 2.79, 19.4 ± 1.47)%, and the relative migration ratio (47.40 ± 3.09, 41.26 ± 4.33)% were higher than those in the control group (34.48 ± 2.03, 21.80 ± 1.03)%. When the expression of COL10A1 was downregulated, the ability of clone formation and wound‐healing migration capacity in TNBC cells was weakened. Upregulated COL10A1 in TNBC cells generated more junctions and longer total segments between vascular endothelial cells, and promoted angiogenesis of the cells, and thus enhanced the tumorigenesis. In TNBC, it was found that COL10A1 might affect epithelial‐mesenchymal transition (EMT) of the cells through Wnt/β‐catenin signaling pathway by the detection of the related pathway proteins. COL10A1 is highly expressed in TNBC, and its high expression leads to poor OS and RFS. COL10A1 may enhance TNBC cell proliferation, migration and tumor‐related angiogenesis, and promote tumorigenesis in vivo via Wnt/β‐catenin signaling.
New insights into immune cells in cancer immunotherapy: from epigenetic modification, metabolic modulation to cell communication
Authors: Qin Sha , Xie Bin , Wang Qingyi , Yang Rui , Sun Jingyue , Hu Chaotao , Liu Shuang , Tao Yongguang , Xiao Desheng 
Published: May 2024

AbstractCancer is one of the leading causes of death worldwide, and more effective ways of attacking cancer are being sought. Cancer immunotherapy is a new and effective therapeutic method after surgery, radiotherapy, chemotherapy, and targeted therapy. Cancer immunotherapy aims to kill tumor cells by stimulating or rebuilding the body's immune system, with specific efficiency and high safety. However, only few tumor patients respond to immunotherapy and due to the complex and variable characters of cancer immune escape, the behavior and regulatory mechanisms of immune cells need to be deeply explored from more dimensions. Epigenetic modifications, metabolic modulation, and cell‐to‐cell communication are key factors in immune cell adaptation and response to the complex tumor microenvironment. They collectively determine the state and function of immune cells through modulating gene expression, changing in energy and nutrient demands. In addition, immune cells engage in complex communication networks with other immune components, which are mediated by exosomes, cytokines, and chemokines, and are pivotal in shaping the tumor progression and therapeutic response. Understanding the interactions and combined effects of such multidimensions mechanisms in immune cell modulation is important for revealing the mechanisms of immunotherapy failure and developing new therapeutic targets and strategies.
Optimal innovation incentive strategies within the health crowdsourcing platform
Authors: Liu Jianyue , Ma Zhiqiang , Zhu Binxin 
Published: May 2024

AbstractLack of incentive strategies within the health crowdsourcing platform has resulted in the loss of patient innovation and the failure in the diffusion of patients' innovations. To solve this problem, we compared four incentive strategies: (i) without incentive, (ii) cost‐sharing incentive, (iii) revenue‐sharing incentive, and (iv) a hybrid incentive strategy combining cost‐sharing and revenue‐sharing. Our analysis indicates that the innovation guidance effect is at its lowest level without incentive strategies, and the hybrid incentive strategy can maximize both innovation enthusiasm and profits. Furthermore, there exists a threshold for revenue‐sharing ratio, making the incentive effect of revenue‐sharing strategy better than that of the cost‐sharing strategy. Finally, short‐sighted thinking among platform participants will reduce the innovation enthusiasm of altruistic patients and the incentive investment of the platform. This study provides guiding principles for the health crowdsourcing platform to regulate online patient innovation solutions.
Dietary Oat β‐Glucan Alleviates High‐Fat Induced Insulin Resistance through Regulating Circadian Clock and Gut Microbiome
Authors: Wang Xingyu , Ye Gaoqi , Wang Zongwei , Wang Ziyuan , Gong Lingxiao , Wang Jing , Liu Jie 
Published: May 2024

ScopeHigh‐fat diet induced circadian rhythm disorders (CRD) are associated with metabolic diseases. As the main functional bioactive component in oat, β‐glucan (GLU) can improve metabolic disorders, however its regulatory effect on CRD remains unclear. In this research, the effects of GLU on high‐fat diet induced insulin resistance and its mechanisms are investigated, especially focusing on circadian rhythm‐related process.Methods and resultsMale C57BL/6 mice are fed a low fat diet, a high‐fat diet (HFD), and HFD supplemented 3% GLU for 13 weeks. The results show that GLU treatment alleviates HFD‐induced insulin resistance and intestinal barrier dysfunction in obese mice. The rhythmic expressions of circadian clock genes (Bmal1, Clock, and Cry1) in the colon impaired by HFD diet are also restored by GLU. Further analysis shows that GLU treatment restores the oscillatory nature of gut microbiome, which can enhance glucagon‐like peptide (GLP‐1) secretion via short‐chain fatty acids (SCFAs) mediated activation of G protein‐coupled receptors (GPCRs). Meanwhile, GLU consumption significantly relieves colonic inflammation and insulin resistance through modulating HDAC3/NF‐κB signaling pathway.ConclusionGLU can ameliorate insulin resistance due to its regulation of colonic circadian clock and gut microbiome.
Design and optimization of a Quasi‐Yagi antenna for 5G communications
Authors: Ala Avanthi , Bactavatchalame Partibane , Karuppiah Senthamilselvan 
Published: May 2024

AbstractA novel Quasi‐Yagi‐Uda antenna on a flexible material is designed and demonstrated in this paper. The antenna is developed on an ultra‐thin polyimide substrate to support dual‐frequency bands centered at 3.8 and 5.2 GHz for 5G and WiFi‐enabled wireless communications. The proposed Quasi‐Yagi‐Uda has a twin‐F‐shaped driven element which is excited using a microstrip line feed. The arms of the driven element are suitably designed to meet the frequency specifications of the proposed antenna. The design of the antenna is carried out using Computer Simulation Technology Microwave Studio while the antenna optimization is performed using the Fire‐Fly algorithm. The optimum geometrical details of the proposed antenna are obtained with a higher rate of convergence. The proposed dual‐band antenna provides 205 and 195 MHz bandwidth in both frequency bands guaranteeing high‐speed wireless communications in the 5G domain. The Quasi‐Yagi‐Uda provides a gain greater than 4.5 dBi in both operating bands with an efficiency greater than 80%. The prototype antenna optimized using the Fire‐Fly algorithm is fabricated and the simulation results are validated.
Integrating IASLC grading and radiomics for predicting postoperative outcomes in stage IA invasive lung adenocarcinoma
Authors: Chen Yong , Wu Jun , You Jie , Gao Mingjun , Lu Shichun , Sun Chao , Shu Yusheng , Wang Xiaolin 
Published: May 2024

AbstractBackgroundThe International Association for the Study of Lung Cancer (IASLC) Pathology Committee introduced a histologic grading system for invasive lung adenocarcinoma (LUAD) in 2020. The IASLC grading system, hinging on the evaluation of predominant and high‐grade histologic patterns, has proven to be practical and prognostic for invasive LUAD. However, there are still limitations in evaluating the prognosis of stage IA LUAD. Radiomics may serve as a valuable complement.PurposeTo establish a model that integrates IASLC grading and radiomics, aimed at predicting the prognosis of stage IA LUAD.MethodsWe conducted a retrospective analysis of 628 patients diagnosed with stage IA LUAD who underwent surgical resection between January 2015 and December 2018 at our institution. The patients were randomly divided into the training set (n = 439) and testing set (n = 189) at a ratio of 7:3. Overall survival (OS) and disease‐free survival (DFS) were taken as the end points. Radiomics features were obtained by PyRadiomics. Feature selection was performed using the least absolute shrinkage and selection operator (LASSO). The prediction models for OS and DFS were developed using multivariate Cox regression analysis, and the models were visualized through nomogram plots. The model's performance was evaluated using area under the curves (AUC), concordance index (C‐index), calibration curves, and survival decision curve analysis (DCA).ResultsIn total, nine radiomics features were selected for the OS prediction model, and 15 radiomics features were selected for the DFS prediction model. Patients with high radiomics scores were associated with a worse prognosis (p < 0.001). We built separate prediction models using radiomics or IASLC alone, as well as a combined prediction model. In the prediction of OS, we observed that the combined model (C‐index: 0.812 ± 0.024, 3 years AUC: 0.692, 5 years AUC: 0.792) achieved superior predictive performance than the radiomics (C‐index: 0.743 ± 0.038, 3 years AUC: 0.633, 5 years AUC: 0.768) and IASLC grading (C‐index: 0.765 ± 0.042, 3 years AUC: 0.658, 5 years AUC: 0.743) models alone. Similar results were obtained in the models for DFS.ConclusionThe combination of radiomics and IASLC pathological grading proves to be an effective approach for predicting the prognosis of stage IA LUAD. This has substantial clinical relevance in guiding treatment decisions for early‐stage LUAD.
The association of fecal incontinence, constipation, and pelvic pain with the course of lower urinary tract symptoms in community‐dwelling men and women
Authors: Mahjoob Dina M. , Knol‐de Vries Grietje E. , de Boer Michiel , van Koeveringe Gommert A. , Blanker Marco H. 
Published: May 2024

AbstractBackgroundFecal incontinence, constipation, and pelvic pain are common pelvic floor symptoms (PFS), and frequently coexist with lower urinary tract symptoms (LUTS). However, their association with the longitudinal trajectory of LUTS have not been well described. Our objective was to investigate the association between PFS and the course of LUTS in community‐dwelling men and women.MethodsMen and women aged ≥16 years were invited to participate in a prospective observational cohort study. At baseline, and after 12 and 24 months, participants filled in the International Consultation on Incontinence Modular Questionnaire (ICIQ‐MLUTS and ICIQ‐FLUTS) for men and women respectively, the Wexner incontinence and constipation scale, and a questionnaire on pelvic pain. Generalized estimating equations were used to examine the association between change scores in defecation problems and pelvic pain, and LUTS change scores.ResultsA total of 694 men and 997 women gave informed consent, with 417 men and 566 women included in the analysis. The mean age was 63.2 ± 12.7 years for men and 58.6 ± 14.8 years for women. The study showed minor changes in LUTS scores over the 0–12 and 12–24‐month periods. Generalized estimating equations revealed positive associations between changes in constipation and fecal incontinence and LUTS changes in both sexes. For instance, a one‐point increase in Wexner constipation score was associated with 0.376 (0.165, 0.587) points higher LUTS change in men and 0.223 (0.109, 0.336) points in women during the 0–12‐month follow‐up. However, associations between changes in pain and LUTS scores varied across sexes and time periods.ConclusionsWe observed minor changes in LUTS over time and weak associations between PFS and LUTS that sometimes differed between males and females, emphasizing the need for sex‐specific considerations. These insights can provide valuable guidance for the development of targeted prevention trials, ultimately aiming to enhance overall pelvic health and patient well‐being.
Secure cross‐chain transactions for medical data sharing in blockchain‐based Internet of Medical Things
Authors: Jiang Bohao , Li Chaoyang , Tang Yu , Xin Xiangjun 
Published: May 2024

SummaryBlockchain technology has greatly promoted the development of the Internet of Medical Things (IoMT) from a centralized form to a distributed form. However, with many independent blockchain‐based IoMT (BIoMT) systems being established by different institutions, these heterogeneous blockchain systems have created a new “data islands” problem. This paper proposes a multi‐chain fusion (MCF) multi‐party governance model based on relay chain technology. The MCF model helps establish cross‐chain interaction and communication among the multiple heterogeneous blockchain systems in different medical institutions through the cross‐chain gateway. Meanwhile, by utilizing the inter‐blockchain transfer protocol (IBTP), the MCF model takes responsibility for legitimacy verification and reliable routing of cross‐chain transactions, thus addressing the “data islands problem” inherent in traditional blockchain‐based medical systems. Then, an elliptic curve signature scheme is adopted to protect user privacy in cross‐chain transactions, which helps establish transaction verification for the MCF model in BIoMT systems. Finally, several experiments are carried out to prove the feasibility of the cross‐chain scheme and the security of the elliptic curve signature scheme, and the performance index of the cross‐chain system is evaluated. The performance results show that the MCF model can provide secure and efficient cross‐chain services for sharing medical data among heterogeneous BIoMT systems, thus addressing the “data islands problem” inherent in traditional blockchain‐based medical systems.
Using participatory video in environmental research
Authors: Nawrath Maximilian , Fisher Jessica C. , Arotoma‐Rojas Ingrid , Davies Zoe G. , Elsey Helen , Cooke Paul , Mistry Jayalaxshmi , Dallimer Martin 
Published: May 2024

Abstract

Tackling environmental challenges that face humanity requires us to acknowledge new ways of working and to cross disciplinary boundaries. However, the methodological toolkit used by environmental researchers to explore the human attitudes, knowledge and behaviours that drive global challenges such as biodiversity loss and climate breakdown remains constrained.

Here, we describe participatory video, a methodology for capturing and communicating knowledge, which goes beyond interviews, focus groups and participant observation. We draw from the literature and our own experience of conducting participatory video projects in Nepal, Guyana and Peru. We demonstrate the diverse ways in which the methodology can be applied to environmental research and highlight its strengths and limitations.

Participatory video provides a more holistic understanding of environmental issues by using multiple types of data, its longer‐term engagement with issues, opening channels of communication between stakeholders, engaging a diversity of knowledge systems and advocating for transformative change.

By taking a participatory video approach, environmental researchers may begin to counter commonplace criticisms about lack of diversity and entrenched colonialism. This simultaneously responds to wider calls for environmental research to engage with social justice issues, represent diverse voices, understand different contexts and acknowledge the role of power. Crucially, this helps build trust amongst all those involved.

By demonstrating how we have successfully used participatory video in projects in conservation, ecology and climate science, we provide guidance for researchers looking to expand their methodological toolkit. Ultimately, we seek to improve the use of participatory methods to help support communities to tackle the environmental challenges that they face.

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