bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of anthropomorphism and racial homophily of virtual influencers in encouraging low‐ versus high‐cost pro‐environmental behaviors
Authors: Wan Calvin , Lee Daisy , Ng Peggy 
Published: May 2024

AbstractVirtual influencers have great potential to shape the audience's perception and motivate behavioral change. Drawing upon anthropomorphism theory and social identity theory, this paper examined the interaction effect of anthropomorphism and racial homophily of virtual influencers in shaping audiences' trust and subsequently pro‐environmental behaviors in low‐ and high‐cost contexts. Two online studies employing experimental materials generated by artificial intelligence were conducted. Study 1 revealed that high anthropomorphism (human‐like virtual influencers) and high racial homophily (local‐like virtual influencers) are more effective for eliciting trust in the context of low‐cost pro‐environmental behaviors. The findings also showed that low racial homophily (foreign‐like virtual influencers) would further weaken the trust level of a virtual influencer in low anthropomorphism (animate‐like virtual influencers). Study 2 aimed to replicate the findings from Study 1 in the context of high‐cost pro‐environmental behaviors. The findings showed that low racial homophily (foreign‐like virtual influencers) enhanced the trust in a high anthropomorphism (human‐like virtual influencers) virtual influencer. The moderated mediation analyses confirmed the hypothesized relationships in the proposed research model. This research advanced our understanding on the moderating role of racial homophily that serves as a cognitive shortcut for low‐cost and quick decisions. However, a low racial homophily (foreign‐like) virtual influencer would be more effective for high‐cost and symbolic pro‐environmental behaviors. These insights provide valuable guidance to businesses, marketers, and environmental advocates aiming to leverage virtual influencers for encouraging sustainability practices.
It is a match! The effect of regulatory fit on new products recommendations
Authors: Zhang Junhui , Balaji M. S. , Luo Jun , Jha Subhash , Dwivedi Yogesh K. 
Published: May 2024

AbstractOnline retailers often recommend new products to consumers. The present study examined the influence of regulatory fit on consumers' click‐through intentions of new products recommended by online retailers. We proposed that regulatory fit resulting from aligning the product's regulatory focus and recommendation message's regulatory orientation positively influences click‐through intention of new product recommendations. In a laboratory study (Study 1), we found that regulatory fit increase consumers' click‐through behaviors of new product recommendations. Study 2 replicated the findings of Study 1 in a controlled online experiment and found support for regulatory fit—click‐through intentions relationship. Study 3 found that regulatory fit increases click‐through intentions for new products but not for existing products. Study 4 supported the mediating role of perceived efficacy and boundary condition of consumer innovativeness in the relationship between regulatory fit and click‐through intentions. This study contributes to the literature on new product adoption, regulatory focus, and product recommendation strategies. Furthermore, it helps online retailors develop effective recommendation strategies for new product recommendations.
Blocking the ATR‐SerRS‐VEGFA pathway targets angiogenesis for UV‐induced cutaneous squamous cell carcinoma
Authors: Lu Hongyan , Peng Zhangsong , Zheng Zhaohui , Li Changxing , Wang Youyi , Liang Liuping , Chen Yuxiang , Zeng Kang 
Published: May 2024

AbstractCutaneous squamous cell carcinoma (cSCC) is the second most prevalent form of skin cancer, with an escalating incidence rate and a notable potential (up to 5%) for metastasis. Ultraviolet radiation (UVA and UVB) exposure is the primary risk factor for cSCC carcinogenesis, with literature suggesting ultraviolet radiation (UVR) promotes vascular endothelial growth factor A (VEGFA) expression. This study aims to investigate UVR‐induced upregulation of VEGFA and explore combination therapeutic strategies. The skin squamous cell carcinoma cell line A431 was exposed to specific durations of ultraviolet radiation. The effect of emodin on ATR/SerRS/VEGFA pathway was observed. The cell masses were also transplanted subcutaneously into mice (n = 8). ATR inhibitor combined with emodin was used to observe the growth and angiogenesis of the xenografts. The results showed that UV treatment significantly enhanced the phosphorylation of SerRS and the expression level of VEGFA in A431 cells (p < 0.05). Treatment with emodin significantly inhibited this expression (p < 0.05), and the combination of emodin and ATR inhibitor further enhanced the inhibitory effect (p < 0.05). This phenomenon was further confirmed in the xenograft model, which showed that the combination of ATR inhibitor and emodin significantly inhibited the expression of VEGFA to inhibit angiogenesis (p < 0.05), thus showing an inhibitory effect on cSCC. This study innovatively reveals the molecular mechanism of UV‐induced angiogenesis in cSCC and confirms SerRS as a novel target to inhibit cSCC angiogenesis and progression in vitro and in vivo studies.
Expression of RIPK1 and FADD are associated with chemosensitivity and survival in head and heck squamous cell carcinoma via tanshinone IIA‐mediated modulation of the RIPK1‐FADD‐Caspase 8 complex
Authors: Shen Bin , Han Wenwen , Tan Xiangrong , Gu Kyle J. , Naseem Danial F. , Zheng Guibin , Li Guojun , Lou Jianlin , Chen Chao 
Published: May 2024

AbstractTanshinone IIA (Tan IIA), a main active ingredient of salvia miltiorrhiza, has a wide range of antitumor effects, while its specific role and mechanism in head and neck squamous cell carcinomas (HNSCC) is not fully understood. Totally 59 primary HNSCC patients underwent two courses of induction chemotherapy before surgery. The association between expression of Fas‐Associated Death Domain (FADD) and receptor interacting protein kinase 1 (RIPK1) and chemotherapy resistance and survival were evaluated. The cell counting kit‐8 was used to detect the effect of Tan IIA on the activity of cisplatin in chemoresistant HNSCC cells through a series of in vitro experiments. The quantitative real‐time reverse‐transcription polymerase chain reaction, Western blot analysis and flow cytometry were used. FADD and RIPK1 expressions were differentially expressed in Chemosensitive and drug‐resistant patients. Furthermore, patients with tumors exhibiting high expression of FADD and RIPK1 had significantly greater risk for chemoresistance and mortality than patients with tumors that had low levels of these proteins. Moreover, Tan IIA reduced the expression of RIPK1 and FADD in HNSCC chemoresistant cell lines, which could increase the chemosensitivity of cisplatin and promote apoptosis. Overexpression of RIPK1 led to attenuation of therapeutic effects of Tan IIA, which were mainly realized through regulation of the RIPK1‐FADD‐Caspase 8 complex. This study is the first to demonstrate the clinical value and role of FADD and RIPK1 in the treatment of HNSCC. This work establishes the proapoptotic effects of Tan IIA and its potential to enhance chemosensitivity in HNSCC by modulating the RIPK1‐FADD‐Caspase 8 complex.
Final outcomes analysis of the cell product SQZ‐PBMC‐HPV Phase 1 trial in incurable HPV16+ solid tumors shows improved overall survival in patients with increased CD8+ T cell tumor infiltration
Authors: Weaver Alice N. , Iams Wade T. , Park Jong Chul , Mita Monica , Holtick Udo , Gordon Michael S. , Rodabaugh Kerry J. , Dhani Neesha , Neupane Prakash , Taylor Matthew , Amanda Duvall E. , Jennings Julia , Miselis Nathan R. , Loughhead Scott , Warren Marshelle S. , Bernstein Howard , Klussmann Jens P. , Baranda Joaquina , Jimeno Antonio 
Published: May 2024

AbstractCancer vaccines strive to induce robust, antigen‐targeted, T‐cell‐mediated immune responses but have struggled to produce meaningful regression in solid tumors. An autologous cell vaccine, SQZ‐PBMC‐HPV, was developed by SQZ Biotechnologies using microfluidic squeezing technology to load PBMCs with HPV16 E6 and E7 antigens in HLA‐A*02+ patients. The SQZ‐PBMC‐HPV‐101 Phase 1 trial (NCT04084951) enrolled patients with incurable HPV16+ cancers. Here, we present a post hoc analysis of the relationship between Posttreatment CD8+ T cell infiltration and patient outcomes. SQZ‐PBMC‐HPV was administered as monotherapy every 3 weeks. Tumor samples were collected pre‐dose and post‐dose 4 weeks after treatment start. Biomarkers including CD8, MHC‐I, E6, E7, GZMB, and Ki67 were evaluated by immunohistochemistry, immunofluorescence, and RNA in situ hybridization, and were correlated with clinical response, survival, and drug product composition. Eighteen patients had paired pre‐ and post‐dose biopsies. Six (33%) had an increase in CD8+ T cell density in tumor parenchyma between screening and C2D8. Patients with increased CD8+ T cell density had improved disease control rate (66.7% vs 16.7%) and median overall survival (606.5 days vs 170.0 days, p = 0.0078). Drug product was significantly enriched for higher T cells and lower monocytes in the increased CD8+ T cell density group. In patients with incurable HPV16+ solid tumors treated with SQZ‐PBMC‐HPV, an increase in CD8+ T cell density within the tumor parenchyma was associated with superior disease control rate and overall survival. The product composition for patients with increased CD8+ T cell density was enriched for T cells.
I123‐FP‐CIT (DaTSCAN) SPECT beyond the Most Common Causes of Parkinsonism: A Systematic Review
Authors: Quintas Sonia , Sanles‐Falagan Reyes , Berbís M. Álvaro 
Published: May 2024

AbstractBackgroundAs the diagnosis of Parkinson's disease (PD) is fundamentally clinical, the usefulness of ioflupane (123I) single‐photon emission computed tomography (SPECT) or DaTSCAN as a diagnostic tool has been a matter of debate for years. The performance of DaTSCAN is generally recommended in the follow‐up of patients with a clinically uncertain diagnosis, especially in those with a suspected essential tremor, drug‐induced parkinsonism, or vascular parkinsonism. However, there is a dearth of DaTSCAN findings regarding neurodegenerative parkinsonisms besides PD and atypical parkinsonisms. To date, a specific nigrostriatal dopamine uptake pattern that would help differentiate PD from the most frequent atypical parkinsonisms is yet to be described. This fact is further complicated by the possible visualization of abnormalities in the uptake pattern in patients with rarer neurodegenerative parkinsonisms.ObjectivesWe aimed to summarize the current literature regarding DaTSCAN findings in patients with rare neurodegenerative parkinsonisms.MethodsThe PubMed database was systematically screened for studies in English or Spanish up to October 15, 2023, using search terms “DaTSCAN”, “ioflupane”, “DaT‐SPECT”, “123I‐FP‐CIT SPECT”, “dopamine transporter imaging”, and “[123I] FP‐CIT SPECT”. Duplicated publications and studies regarding PD, atypical parkinsonisms, dystonia‐parkinsonism, essential tremor, and parkinsonism due to non‐degenerative causes were excluded.ResultsThe obtained results were reviewed and summarized, including DaTSCAN findings in fragile X‐associated tremor/ataxia syndrome, prion diseases, Huntington's disease, spinocerebellar ataxia, hereditary spastic paraparesis, metabolic disorders, and other diseases (anti‐IgLON5 disease, ring chromosome 20 syndrome, chorea‐acanthocytosis, and neuronal ceroid lipofuscinosis).ConclusionsThis review highlights the need to determine in the future the utility and cost‐effectiveness of DaTSCAN, both as a diagnostic and a prognostic tool, in patients with parkinsonian symptoms in rare neurodegenerative diseases.
Special economic zone dynamics and firm performance: Evidence from an emerging economy
Authors: Ackah Charles Godfred , Osei Robert Darko , Kusi Baah Aye 
Published: May 2024

AbstractThe empirical literature on Special economic zones (SEZs) has shown that SEZs have become critical policy tools for advancing economic and firm performance, especially in developing economies where financial capital, human capital, technology and technical know‐how to drive these performances are in limited supply. While the importance and effects of SEZs cannot be overemphasised and are well documented, particularly in Asia, SEZs' operationalisation, structure and policy practice appear to vary, especially in Ghana and hence a need to examine SEZ effects on firm performance in Ghana. Thus, following the difference in the structure and practice of SEZs and its limited empirical evidence in African emerging economies, this present study employs analysis of variance, treatment estimation and regression models covering 328 firms between 2018 and 2021 to shed insights on how SEZ dynamics/features affect firm performance (measured with total factor productivity, labour productivity, profitability, revenue generation and value added) in Ghana. Our results suggest firms operating under SEZ dynamics have varying significant effects on firm performance. Thus, while firms registered as SEZ firms and operating in SEZ enclaves and firms registered as SEZ firms and operating outside SEZ enclaves have significant positive effects on the performance indicators of firms, firms that are not registered as SEZ firms and operating outside SEZ enclaves detracted firm performance. Clearly, firms that possess SEZ dynamics/features tend to promote performance of firms as denoted in the empirical literature and theoretical approaches to SEZ. Arguably, the tax holidays, cheaper tariffs and infrastructural benefits derived by SEZ registered firms boost their productivity, revenue and profit performance higher than non‐SEZ registered firms. These results suggest policymakers/government should reduce administrative bottlenecks of registering as SEZ firms and operating in SEZ enclaves to increase the number of SEZ firm operations to induce performance and create room for fiscal revenue.
The two‐stage presale pricing for online products considering anchoring effect and payment pain reduction
Authors: Liu Xuwang , Zhang Yujie , Wang Junwei 
Published: May 2024

AbstractOnline product pricing is an important research field in the platform economy, and a two‐stage mixed presale is a mainstream mode of online sales. In the process of online consumption, the payment method and presale mode have an important impact on consumer behaviour and product pricing. Based on the two‐stage mixed presale mode, this study considers the impact of anchoring and the payment pain reduction effect on consumer behaviour, establishes the corresponding product pricing model and obtains the optimal presale price, sales and profit. It sheds light on the influence mechanism of anchoring and the payment pain reduction effect on consumer behaviour and online product pricing. Theoretical and numerical analyses reveal that the payment pain reduction effect can help to raise the product price, stimulate market vitality and bring higher profits for online retailers, and the anchoring effect and consumers' loss aversion psychology can enhance the profits and sales of online retailers, but they will discourage setting high prices for products. The research results will further enrich the relevant research on customer behaviour and product pricing in the platform economy and will provide decision bases for platform enterprises and online retailers to participate in presale activities and formulate product pricing strategies.
An ensemble learning strategy for multi‐source hydrogen embrittlement data by introducing missing information
Authors: Gong Xujie , Lei Ruichao , Sun Ruize , Jiang Xue , Su Yanjing , Yan Yu 
Published: May 2024

AbstractAccurately and quickly predicting hydrogen embrittlement performance is critical for the service of metal materials. However, due to multi‐source heterogeneity, existing hydrogen embrittlement data are missing, making it impractical to train reliable machine learning models. In this study, we proposed an ensemble learning training strategy for missing data based on the Adaboost algorithm. This method introduced a mask matrix with missing data and enabled each round of training to generate sub‐datasets, considering missing value information. The strategy first trained a subset of features based on the existing dataset and a selected method and continuously focused on the combination of features with the highest error for iterative training, where the mask matrix of the missing data was used as the input to fit the weights of each base learner using a neural network. Compared with directly modeling on highly sparse data, the predictive ability of this strategy was significantly improved by approximately 20%. In addition, in the testing of new samples, the predicted mean absolute error of the new model was successfully reduced from 0.2 to 0.09. This strategy offers good adaptability to the hydrogen embrittlement sensitivity of different sizes and can avoid interference from feature importance caused by filling data.
Design and performance analysis of OAM‐based multidimensional multiplexing RoF‐PON integrated access system
Authors: Ding Qing‐an , Ren Jiali , Jiang Meiyu , Liu Huixin , Guo Xiaohan , Liu Chunyan , Niu Qun , Zhang Yongqi , Lei Yang 
Published: May 2024

AbstractThe unique advantage of orbital angular momentum (OAM) provides a novel approach to breaking through the limitations of high‐capacity and long‐distance transmission in the conventional radio‐overfiber passive optical network (RoF‐PON) hybrid access network. Introducing the OAM division multiplexing (OAM‐DM) based on Laguerre–Gaussian (LG) beams into the RoF‐PON, an innovative multidimensional system architecture is proposed, which integrates with polarization‐division multiplexing (PDM), wavelength‐division multiplexing (WDM), and orthogonal frequency‐division multiplexing (OFDM) technologies. Successful long‐distance transmission of both the downstream 40 GHz radio OFDM signal and the upstream 40 Gbps on‐off keying (OOK) signal over 80 km are achieved. Additionally, at the optical network unit side, low‐cost upstream carrier re‐modulation technology and flexible access for both wired and wireless signals are realized. The proposed RoF‐OAM‐DM‐PDM‐WDM‐OFDM‐PON architecture offers a dependable solution for high‐capacity and low‐cost future communication systems, holding great importance in achieving flexible access networks.
Patients' and rheumatologists' perceptions on dose reduction of rituximab in rheumatoid arthritis
Authors: Bertrand Delphine , Deprez Anke , Doumen Michaël , De Cock Diederik , Pazmino Sofia , Marchal Anja , Thelissen Marc , Joly Johan , De Meyst Elias , Neerinckx Barbara , Westhovens René , Verschueren Patrick 
Published: May 2024

AbstractObjectiveThe recommended dose of a rituximab course for the treatment of Rheumatoid Arthritis (RA) consists of two infusions of 1000 mg with a 2‐week interval. Evidence is growing that a lower dose could be as effective. We aimed to investigate patients' and rheumatologists' perceptions on dose reduction of rituximab.MethodsPatients with RA treated with rituximab, and rheumatologists were invited for a qualitative study via individual semi‐structured interviews. Participants were recruited based on purposive sampling to ensure diversity. Interviews were analysed according to the principles of grounded theory and the constant comparative method.ResultsSixteen patients and 13 rheumatologists were interviewed. Patients and rheumatologists perceived the benefits of rituximab dose reduction for reasons of safety and societal costs. Furthermore, available evidence for the effectiveness of lower doses was mentioned as an argument in favour, in addition to the possibility to tailor the dose based on the patients' clinical manifestations. However, patients and rheumatologists had concerns about the potential loss of effectiveness and quality of life. Moreover, some rheumatologists felt uncomfortable with dose reduction due to insufficient experience with rituximab in general. Patients and rheumatologists emphasised the importance of shared decision‐making, underscoring the pivotal role of physicians in this process by explaining the reasoning behind dose reduction.ConclusionAlthough some concerns on effectiveness were perceived, both patients and rheumatologists saw potential benefits of dose reduction in terms of safety, societal costs, and application of a personalised approach. As a result, most rheumatologists and patients showed a willingness to consider dose reduction strategies.
Rasch analysis of the Unidimensional Self‐Efficacy Scale in Neuromuscular Disorders and comparison between sex, age, and diagnoses
Authors: Fulton Joshua P. J. , Holt James K. L. , Mills Roger J. , Young Carolyn A. 
Published: May 2024

AbstractIntroduction/AimsSelf‐efficacy reflects a person's perceptions of their capabilities for specific tasks and influences motivation and performance. The Unidimensional Self‐Efficacy in Neuromuscular Disorders (USE‐NM) was modified from the Multiple Sclerosis (MS) USE‐MS scale and administered to patients attending a specialist neuromuscular clinic. The aim was to investigate this measure in neuromuscular disorders and to compare between patient sex, age, and diagnosis.MethodsThe USE‐NM was posted to patients recruited from a specialist neuromuscular clinic at the Walton Centre. Responses were subjected to Rasch analysis using RUMM2030 software and descriptive statistics were performed using SPSS version 28.ResultsOne hundred and ninety‐eight patients (56.1% male) grouped by age (<50; 50–59; 60–69; and >69 years) and with varied NM disorders returned the USE‐NM. It did not meet the Rasch model expectations due to disordered thresholds of items 6 and 8 (“Sometimes I feel inadequate as a person because of my neuromuscular disorder” and “I feel that my social life would be better if I did not have a neuromuscular disorder”). Following item re‐scoring, the modified USE‐NM satisfied the Rasch model with a unidimensional scale free from differential item functioning and an overall chi‐square probability of 0.146 with good reliability and validity. Post hoc nonparametric testing showed no significant difference in fatigue between sex, age, and neuromuscular diagnoses.DiscussionThe Rasch‐modified USE‐NM offers a measure of self‐efficacy for neuromuscular disorders encountered in a typical specialist clinic. Future considerations could be given to assessing any benefits of multidisciplinary team input, across a specialist neuromuscular service.
Error estimates for completely discrete FEM in energy‐type and weaker norms
Authors: Angermann Lutz , Knabner Peter , Rupp Andreas 
Published: May 2024

AbstractThe paper presents error estimates within a unified abstract framework for the analysis of FEM for boundary value problems with linear diffusion‐convection‐reaction equations and boundary conditions of mixed type. Since neither conformity nor consistency properties are assumed, the method is called completely discrete. We investigate two different stabilized discretizations and obtain stability and optimal error estimates in energy‐type norms and, by generalizing the Aubin‐Nitsche technique, optimal error estimates in weaker norms.
Public administration and development in (historical) perspective
Authors: Elliott Ian C. , Puppim de Oliveira Jose A. , Wu Alfred M. 
Published: May 2024

AbstractSince 1949, the journal Public Administration and Development has gone through changes in name and scope, in author demographics and background, and in readership and the topics covered. The professional‐oriented articles in the first years of the journal have evolved to become more academic theory‐oriented articles in recent years. Drawing on mixed methods, the authors conducted in‐depth analyses using data from the journal to highlight changes in research themes and geographic foci. The study provides insights into the historical development of public administration in developing contexts, the journal's contributions to the field, and maps out potential future research trends.