bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tracking shifts in Society Islands marine subsistence through time: Intra‐site analysis of faunal remains and fishing gear
Authors: Ohman Alexis , Kahn Jennifer G. 
Published: April 2024

AbstractWe discuss new data from Colonization Phase and Early Expansion/Development Phase assemblages in the pre‐contact Society Islands. We focus on analysis of marine faunal remains and fishing gear to infer diachronic shifts in subsistence practices at two well‐dated coastal sites. Both Colonization Phase (AD 950–1200) and Early Expansion Phase (AD 1200–1450) faunal assemblages are dominated by fish and mollusks as opposed to animal domesticates. Colonization Phase assemblages see higher capture of Scombrids and higher capture of marine mammals and turtle. Early Expansion fishhook assemblages and faunal remains document a movement towards increased capture of reef fish as well as the adoption of local styles and locally specific fishing practices. Overall, the diachronic trend in the Society Island diets is towards a decrease in turtle, marine mammal, and wild bird remains and an increase in terrestrial domesticated species roughly two hundred years after colonization, similar to patterns seen elsewhere in Eastern Polynesia.
Chemistry of heterocycles as carbonic anhydrase inhibitors: A pathway to novel research in medicinal chemistry review
Authors: Bendi Anjaneyulu , Taruna  , Rajni  , Kataria Sweety , Singh Lakhwinder , Kennedy John F. , Supuran Claudiu T. , Raghav Neera 
Published: April 2024

AbstractNowadays, the scientific community has focused on dealing with different kinds of diseases by exploring the chemistry of various heterocycles as novel drugs. In this connection, medicinal chemists identified carbonic anhydrases (CA) as one of the biologically active targets for curing various diseases. The widespread distribution of these enzymes and the high degree of homology shared by the different isoforms offer substantial challenges to discovering potential drugs. Medicinal and synthetic organic chemists have been continuously involved in developing CA inhibitors. This review explored the chemistry of different heterocycles as CA inhibitors using the last 11 years of published research work. It provides a pathway for young researchers to further explore the chemistry of a variety of synthetic as well as natural heterocycles as CA inhibitors.
Subjective wellbeing of autistic adolescents and young adults: A cross sectional study
Authors: Ridgway Kathryn , Macmillan Caitlin , Demmer David H. , Hooley Merrilyn , Hedley Darren , Westrupp Elizabeth , Stokes Mark A. 
Published: April 2024

AbstractSubjective wellbeing (SWB) represents an individual's perception of wellness that is supported by homeostatic mechanisms. These mechanisms are proposed to be maintained by low negative affect and high positive affect, although less is known about these mechanisms and SWB in autism. The current cross‐sectional study aimed to compare patterns of positive affect, negative affect (Positive Affect and Negative Affect Scale), and SWB (Personal Wellbeing Index‐School Children) between autistic (n = 53) and non‐autistic (n = 49) individuals aged 10–22 years (Mage = 13.97, SD = 3.13). Between‐group t‐tests revealed that compared with same‐age peers, autistic participants scored lower SWB overall (p < 0.001). In both groups average SWB scores fell into the higher range, however, autistic participants were three‐times more likely to fall below this range when compared to non‐autistic participants. Negative affect had a higher intercept in the autistic sample, but no difference in slopes were observed. A hierarchical multiple regression revealed that diagnosis, positive affect, and negative affect significantly predicted SWB in our sample. Between‐group t‐tests found no significant difference in positive affect or negative affect across age between the autistic and non‐autistic samples. In autistic participants, positive affect increased across age as SWB decreased, whilst negative affect remained stable, a pattern inconsistent with homeostatic SWB. The current study is overall consistent with the homeostatic explanation for SWB within autism; however, we identified potential differences between autistic and non‐autistic participants in the contribution of positive affect and negative affect to homeostatic protect mood across development.
UPLC/Q‐TOF–MS‐based metabolomics and molecular docking analysis of Bifidobacterium adolescentis exposure to levofloxacin
Authors: Feng Shisui , Guo Yue , Wang Qianyi , Meng Mingwei , Liu Xi , Zhang Chi , Zheng Hua , Guo Hongwei , Lu Rigang , Li Danfeng , Su Zhiheng , Song Hui , Liang Yonghong 
Published: April 2024

AbstractAntibiotic‐associated diarrhea is a common adverse reaction caused by the widespread use of antibiotics. The decrease in probiotics is one of the reasons why antibiotics cause drug‐induced diarrhea. However, few studies have addressed the intrinsic mechanism of antibiotics inhibiting probiotics. To investigate the underlying mechanism of levofloxacin against Bifidobacterium adolescentis, we used a metabolomics mass spectrometry‐based approach and molecular docking analysis for a levofloxacin‐induced B. adolescentis injury model. The results showed that levofloxacin reduced the survival rate of B. adolescentis and decreased the number of B. adolescentis. The untargeted metabolomics analysis identified 27 potential biomarkers, and many of these metabolites are involved in energy metabolism, amino acid metabolism and the lipid metabolism pathway. Molecular docking showed that levofloxacin can bind with aminoacyl‐tRNA synthetase and lactic acid dehydrogenase. This result provides a novel insight into the mechanism of the adverse reactions of levofloxacin.
Comparative electroencephalography analysis: Marathon runners during tapering versus sedentary controls reveals no significant differences
Authors: Moussiopoulou J. , Handrack‐Bonnet M. , Pross B. , Pogarell O. , Keeser D. , Halle M. , Falkai P. , Scherr J. , Hasan A. , Roeh A. 
Published: April 2024

AbstractIntroductionPrevious studies described various adaptive neuroplastic brain changes associated with physical activity (PA). EEG studies focused mostly on effects during or shortly after short bouts of exercise. This is the first study to investigate the capability of EEG to display PA‐induced long‐lasting plasticity in runners compared to a sedentary control group.MethodsThirty trained runners and 30 age‐ and sex‐matched sedentary controls (SC) were included as a subpopulation of the ReCaP (Running effects on Cognition and Plasticity) study. PA was measured with the International Physical Activity Questionnaire (IPAQ). Resting‐state EEG of the runners was recorded in the tapering phase of the training for the Munich marathon 2017. Power spectrum analyses were conducted using standardized low‐resolution electromagnetic tomography (sLORETA) and included the following frequency bands: delta: 1.5–6 Hz, theta: 6.5–8.0 Hz, alpha1: 8.5–10 Hz, alpha2: 10.5–12.0 Hz, beta1: 12.5–18.0 Hz, beta2: 18.5–21.0 Hz, beta3: 21.5–30.0 Hz, and total power (1.5–30 Hz).ResultsPA (IPAQ) and BMI differed significantly between the groups. The other included demographic parameters were comparable. Statistical nonparametric mapping showed no significant power differences in EEG between the groups.DiscussionHeterogeneity in study protocols, especially in time intervals between exercise cessation and EEG recordings and juxtaposition of acute exercise‐induced effects on EEG in previous studies, could be possible reasons for the differences in results. Future studies should record EEG at different time points after exercise cessation and in a broader spectrum of exercise intensities and forms to further explore the capability of EEG in displaying long‐term exercise‐induced plasticity.
Knowledge mapping of neonatal electroencephalogram: A bibliometric analysis (2004–2022)
Authors: Zhang Ruijie , Shi Lifeng , Zhang Lu , Lin Xinao , Bao Yunlei , Jiang Feng , Wu Chuyan , Wang Jimei 
Published: April 2024

AbstractBackgroundElectroencephalography (EEG), a widely used noninvasive neurophysiological diagnostic tool, has experienced substantial advancements from 2004 to 2022, particularly in neonatal applications. Utilizing a bibliometric methodology, this study delineates the knowledge structure and identifies emergent trends within neonatal EEG research.MethodsAn exhaustive literature search was conducted on the Web of Science Core Collection (WoSCC) database to identify publications related to neonatal EEG from 2004 to 2022. Analytical tools such as VOSviewer, CiteSpace, and the R package “bibliometrix” were employed to facilitate this investigation.ResultsThe search yielded 2501 articles originating from 79 countries, with the United States and England being the predominant contributors. A yearly upward trend in publications concerning neonatal EEG was observed. Notable research institutions leading this field include the University of Helsinki, University College London, and University College Cork. Clinical Neurophysiology is identified as the foremost journal in this realm, with Pediatrics as the most frequently co‐cited journal. The collective body of work from 9977 authors highlights Sampsa Vanhatalo as the most prolific contributor, while Mark Steven Scher is recognized as the most frequently co‐cited author. Key terms such as “seizures,” “epilepsy,” “hypoxic‐ischemic encephalopathy,” “amplitude‐integrated EEG,” and “brain injury” represent the focal research themes.ConclusionThis bibliometric analysis offers the first comprehensive review, encapsulating research trends and progress in neonatal EEG. It reveals current research frontiers and crucial directions, providing an essential resource for researchers engaged in neonatal neuroscience.
Executive functions and brain morphology of male and female dominant and subordinate cichlid fish
Authors: Guadagno Angelo , Triki Zegni 
Published: April 2024

AbstractBackgroundLiving in a social dominance hierarchy presents different benefits and challenges for dominant and subordinate males and females, which might in turn affect their cognitive needs. Despite the extensive research on social dominance in group‐living species, there is still a knowledge gap regarding how social status impacts brain morphology and cognitive abilities.MethodsHere, we tested male and female dominants and subordinates of Neolamprologus pulcher, a social cichlid fish species with size‐based hierarchy. We ran three executive cognitive function tests for cognitive flexibility (reversal learning test), self‐control (detour test), and working memory (object permanence test), followed by brain and brain region size measurements.ResultsPerformance was not influenced by social status or sex. However, dominants exhibited a brain–body slope that was relatively steeper than that of subordinates. Furthermore, individual performance in reversal learning and detour tests correlated with brain morphology, with some trade‐offs among major brain regions like telencephalon, cerebellum, and optic tectum.ConclusionAs individuals’ brain growth strategies varied depending on social status without affecting executive functions, the different associated challenges might yield a potential effect on social cognition instead. Overall, the findings highlight the importance of studying the individual and not just species to understand better how the individual's ecology might shape its brain and cognition.
Exploring the potential of bovine colostrum as a bioactive agent in human tissue regeneration: A comprehensive analysis of mechanisms of action and challenges to be overcome
Authors: dos Santos Pedro Rassier , Kraus Rosana Basso , da Silva Nascente Patrícia 
Published: April 2024

AbstractThe study examines bovine colostrum as a potent source of bioactive compounds, particularly growth factors, for tissue regeneration in humans. While previous research has hinted at therapeutic benefits, a comprehensive understanding of its mechanisms remains elusive, necessitating further investigation. This review analyzes nine selected scientific articles on bovine colostrum's bioactive potential in tissue regeneration. In vitro studies highlight its positive impact on cell behavior, including reduced proliferation and induced differentiation. Notably, optimal concentrations and specific colostrum components, such as extracellular vesicles and insoluble milk fat, show more favorable outcomes. In vivo studies underscore bovine colostrum as a promising natural resource for wound healing, despite some studies failing to identify associated benefits. Further research is crucial to unravel the intricate mechanisms, grasp the full potential in regenerative medicine, and develop more effective wound healing therapies. This refined understanding will pave the way for harnessing the complete regenerative potential of bovine colostrum in clinical applications.
Characterizing an injectable alginate hydrogel as a co‐encapsulating system for beta cells and curcumin in type 1 diabetes therapy
Authors: Abbasi Parisa , Alemzadeh Iran , Vossoughi Manouchehr 
Published: April 2024

AbstractEncapsulating insulin‐secreting cells within biocompatible hydrogels is a tissue engineering approach for type 1 diabetes treatment. Macroencapsulation is preferred over other encapsulation methods due to its easy implantation and retrieval. However, this treatment has challenges, including the need for invasive surgery for macrocapsule implantation and host response, resulting in fibrotic overgrowth around the implant and subsequent failure of the graft. Herein, an injectable alginate hydrogel, fabricated by different concentrations of as a retarding agent, was applied to avoid surgery. According to characterization tests, hydrogel made by 0.3 M showed a higher swelling ratio and diffusion coefficient, appropriate for the diffusion of nutrients, oxygen, and insulin. It was also stiffer with a lower swelling rate, demonstrating more robust elastic and solid‐like behaviour, suitable for cell attachment. Its small pore size (133.04 ± 53.28 μm), additionally, was essential for inhibiting immunoglobulins penetration. Thus, this hydrogel was used for RIN‐5F cells encapsulation and demonstrated good biocompatibility (>88% viability), and maintained the insulin‐releasing function of cells. Afterward, we co‐encapsulated beta cells with curcumin as an anti‐inflammatory drug and investigated the effect of this agent on cell behaviour in vitro. It was indicated that curcumin did not adversely affect viability and insulin secretion.
Numerical analysis and optimization on flow and heat transfer performance of HPD‐type perforated fins
Authors: Dai Hao , Wang Ling , Yang Peng , Li Aiyan , Wang Fazhong , Liu Yingwen 
Published: April 2024

AbstractIn this paper, we determine the trends and weights of the structural parameters on the heat transfer, flow resistance and comprehensive performance of high pressure direction (HPD)‐type perforated fins using Taguchi method and analysis of variance (ANOVA). The findings underscore the fin height as the most pivotal element affecting comprehensive performance, with its contribution ratio of 42.2%. Ultimately, the highest j‐factor, the lowest f‐factor, and the maximum JF‐factor were obtained as the objective functions, yielding the three most optimal sets of parameters. The findings reveal a remarkable 89.7% reduction in the f‐factor of the optimized HPD‐type perforated fins, accompanied by a substantial 127% augmentation in the JF‐factor compared to the HPD‐type fins.
Emerging Bio‐relevant Applications of Polymer Mechanochemistry
Authors: Liu Wenjie , Qian Hai 
Published: April 2024

AbstractPolymer mechanochemistry has rapidly evolved since the mid‐2000s. Recent advancements highlight the development of mechanophore platforms for the controlled release of bioactive payloads and the exploration of biocompatible activation strategies. These platforms, ranging from furan‐maleimide Diels‐Alder adducts to disulfide motifs with β‐carbonate linkages, demonstrate promising prospects in targeted drug delivery. Additionally, supramolecular assemblies and free radical‐generating mechanophores present innovative avenues for potential therapeutic applications. Biocompatible activation methods, notably high‐intensity and/or low‐intensity focused ultrasound, hold potential for in vivo applications. However, challenges persist in comprehending the fundamental physics of ultrasound and its utilization for activation. Future directions emphasize the importance of simplicity in biocompatible platforms and polymer designs, stability under physiological conditions, and precise control of mechanical activation for enhanced biomedical and clinical utility. Despite the aforementioned chemical and technical obstacles, the outlook for polymer mechanochemistry in biomedical and clinical applications remains promising, urging continued exploration and advancement.

Key Scientists
Composites with Immobilized Bioactive Spirulina on an Inorganic Substrate (Yellow Clay, Hydroxyapatite, SiO2, TiO2, ZnO)
Authors: Kowalska Klaudia , Skwarek Ewa , Demianenko Evgeny , Paientko Victoria 
Published: April 2024

AbstractIn order to improve the structural properties of clays and composites of powdered spirulina, clay, nanosilica, hydroxyapatite, TiO2 and ZnO were used as an additive for mechanical processing. As a result, composites with natural nanostructured materials (NNM) are prepared with improved structural properties and bioactivity. The mixtures based on NNM with crystalline kaolinite, clays and admixtures were processed in a knife mill. The materials were characterized using FTIR spectroscopy, nitrogen adsorption and desorption, SEM release of bioactive components (anthocyanin 0,004–0,07 mg/g; chlorophyll 20–29 mg/g), composite toxicity level (below 25%), particle size measurement and surface charge density, zeta potential. Adsorption enthalpies during the formation of an intermolecular complex during the interactions of an anthocyanin molecule with the appropriate component of the composite were also calculated. There are regularities in the characteristics depending on the type of NNM, particle morphology and textural features of solids. The morphological and structural properties of the components changed slighty in the blends because the processing was conducted under relatively low mechanical stress. The morphological, textural and structural characteristics of the composites as well as the transformation to a nanostructured state, assume great bioactive activity of the composites, interesting for practical applications in medicine and cosmetics.
The Chemistry of Chelation for Built Heritage Cleaning: The Removal of Copper and Iron Stains
Authors: Canevali Carmen , Sansonetti Antonio , Rampazzi Laura , Monticelli Damiano , D'Arienzo Massimiliano , Di Credico Barbara , Ghezzi Elena , Mostoni Silvia , Nisticò Roberto , Scotti Roberto 
Published: April 2024

AbstractChelators are widely used in conservation treatments to remove metal stains from marble, travertine, and limestone surfaces. In the current review the chemical aspects underlying the use of chelators for the removal of copper and iron stains from built heritage are described and clear criteria for the selection of the most efficient stain removal treatment are given. The main chelator structural features are outlined and the operating conditions for effective metal stain removal (pH, time of application, etc.) discussed, with a particular emphasis on the ability to form stable metal complexes, the high selectivity towards the metal that should be removed, and the high sustainability for the environment. Dense matrices often host chelators for higher effectiveness, and further research is required to clarify their role in the cleaning process. Then, relevant case studies of copper and iron stain removal are discussed. On these bases, the most effective chelators for copper and stain removal are indicated, providing chemists and conservation scientists with scientific support for conservation operations on stone works of art and opening the way to the synthesis of new chelators.
Abuse and Neglect of Children With Specific Learning Disorders in Türkiye: A Case–Control Study
Authors: Uzun Mehmet Erdem , Koşan Yekta , Şirin Hande 
Published: April 2024

ABSTRACTBackgroundAlthough it is often stated that children with special needs are at risk of being abused and neglected, research conducted on the abuse of children with specific learning disorders (SLDs) is limited.MethodsThis case–control study aims to compare exposure to neglect and abuse among children diagnosed with SLDs (case group) and children with typical development (control group). The study included children aged 6 to 12 years who were referred to the Child and Adolescent Psychiatry Outpatient Clinic and Pediatric Clinic of a hospital in Türkiye. The data collection process included 196 participants and lasted for 7 months in 2020.ResultsBased on the analysis of the data collected with the Schedule for Affective Disorders and Schizophrenia for School Age Children‐Present and Lifetime Turkish Version (K‐SADS‐PL‐T) and the Abuse Assessment Questionnaire, we determined that children with SLDs were physically and emotionally abused more than the children of the control group. In addition, they witnessed violence between their parents more than the control group. Physical abuse, emotional abuse and witnessing family violence were identified as significant predictors for SLD.ConclusionsThe presence of SLDs is a significant risk factor for children to be exposed to abuse even in the absence of ADHD as a comorbidity.
Direct Palladium‐Catalyzed C5‐Arylation of 1,3,4‐Oxadiazoles with Aryl Chlorides Promoted by Bis(di‐isopropylphosphino) Ferrocene
Authors: Gelin Loris , Sabbadin Henri , Cattey Hélène , Fleurat‐Lessard Paul , Hierso Jean‐Cyrille , Roger Julien 
Published: April 2024

AbstractThe direct palladium‐catalyzed C−H arylation of 1,3,4‐oxadiazoles with challenging aryl chloride substrates is promoted by the use of a specifically designed electron‐rich ferrocenyl diphosphane. This protocol employs 0.5 to 1.0 mol % catalyst loading without any additives such as copper or ammonium salts, and equally tolerates electron‐donating and electron‐withdrawing substituents on the (heteroaryl)aryl halides, as illustrated by the efficient synthesis in 86 % yield of the anti‐tubercular agent PHOXPY (2‐(5‐phenyl‐1,3,4‐oxadiazol‐2‐yl)pyrazine) by a late‐stage arylation using 2‐chloropyrazine.
Electrocatalysis‐driven sustainable plastic waste upcycling
Authors: Wang Gaihong , Chen Zhijie , Wei Wei , Ni Bing‐Jie 
Published: April 2024

AbstractWith large quantities and natural resistance to degradation, plastic waste raises growing environmental concerns in the world. To achieve the upcycling of plastic waste into value‐added products, the electrocatalytic‐driven process is emerging as an attractive option due to the mild operation conditions, high reaction selectivity, and low carbon emission. Herein, this review provides a comprehensive overview of the upgrading of plastic waste via electrocatalysis. Specifically, key electrooxidation processes including the target products, intermediates and reaction pathways in the plastic electro‐reforming process are discussed. Subsequently, advanced electrochemical systems, including the integration of anodic plastic monomer oxidation and value‐added cathodic reduction and photo‐involved electrolysis processes, are summarized. The design strategies of electrocatalysts with enhanced activity are highlighted and catalytic mechanisms in the electrocatalytic oxidation of plastic waste are elucidated. To promote the electrochemistry‐driven sustainable upcycling of plastic waste, challenges and opportunities are further put forward.