bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal Periodontitis Treatment and Child Neurodevelopment at 24 to 28 Months of Age
Authors: Michalowicz Bryan S. , Hodges James S. , Lussky Richard C. , Bada Henrietta , Rawson Twila , Buttross L. Susan , Chiriboga Claudia , DiAngelis Anthony J. , Novak M. John , Buchanan William , Mitchell Dennis A. , Papapanou Panos N. 
Published: April 2011

BACKGROUND:
Some maternal infections are associated with impaired infant cognitive and motor performance. Periodontitis results in frequent bacteremia and elevated serum inflammatory mediators.

OBJECTIVE:
The purpose of this study was to determine if periodontitis treatment in pregnant women affects infant cognitive, motor, or language development.

METHODS:
Children born to women who had participated in a previous trial were assessed between 24 and 28 months of age by using the Bayley Scales of Infant and Toddler Development (Third Edition) and the Preschool Language Scale (Fourth Edition). Information about the pregnancy, neonatal period, and home environment was obtained through chart abstractions, laboratory test results, and questionnaires. We compared infants born to women treated for periodontitis before 21 weeks' gestation (treatment group) or after delivery (controls). In unadjusted and adjusted analyses, associations between change in maternal periodontal condition during pregnancy and neurodevelopment scores were tested by using Student's t tests and linear regression.

RESULTS:
A total of 411 of 791 eligible mother/caregiver-child pairs participated. Thirty-seven participating children (9.0%) were born at &lt;37 weeks' gestation. Infants in the treatment and control groups did not differ significantly for adjusted mean cognitive (90.7 vs 91.4), motor (96.8 vs 97.2), or language (92.2 vs 92.1) scores (all P &gt; .5). Results were similar in adjusted analyses. Children of women who experienced greater improvements in periodontal health had significantly higher motor and cognitive scores (P = .01 and .02, respectively), although the effect was small (∼1-point increase for each SD increase in the periodontal measure).

CONCLUSION:
Nonsurgical periodontitis treatment in pregnant women was not associated with cognitive, motor, or language development in these study children.
In vitro Regeneration of the Medicinal Herb of Nilgiri shola, Acmella calva L. from Leaf Derived Callus
Authors: Senthilkumar P. , Paulsamy S. , Vijayakumar K. K. , Kalimuthu K. 
Published: April 2011

Callus culture was initiated from leaf discs on MS supplemented with BAP, NAA and Kn. The highest frequency (95%) of organogenic callus induction was observed in MS containing BAP at 3.0 mg/l and NAA at 0.3 mg/l. Development of adventitious shoots occurred when the calli were subcultured on MS supplemented with BAP alone at the rate of 3.0 mg/l (80%) and BAP with NAA at the rate of 3.0 and 0.3 mg/l, respectively (95%) and BAP with Kn at the rate of 3.0 and 0.3 mg/l, respectively (70%). The root initiation and the rate of growth were higher in the basal medium containing BAP at 3.0 and 2.5 mg/l. The plantlets were establish successfully in the hardening medium composed by coir pith and soil (1 : 1).Key words: Acmella calva, Leaf derived callus, Nilgiris, IndiaÂ Â Plant Tissue Cult. & Biotech. 17(2): 109-114, 2007Â DOI: 10.3329/ptcb.v17i2.2566
Determining Genetic Diversity of Some Jute Varieties and Accessions Using RAPD Markers
Authors: Haque Samiul , Begum Selina , Sarker R.H. , Khan Haseena 
Published: April 2011

The genetic diversity of 18 jute genotypes of the two cultivated species Corchorus capsularis L. and C. olitorius L. which include released varieties and collected races, referred to as accessions was evaluated. DNA profiling was generated using sequence independent RAPD markers. A total of 140 scorable loci were observed and a dendrogram was constructed with these markers. The relationship that is portrayed by this clustering also agreed with the available pedigree information on jute. Two major clusters representing the two species were resolved among the genotypes that were examined in the study. This genetic distance information could be useful in breeding programs in order to introduce agronomically important traits such as short field duration, low temperature tolerance, snow white fibre, higher harvest index etc. From the study one C. olitorius and two C. capsularis varieties were found more suitable for their selection as seed parent against different accessions for improvement because of their higher genetic distant relationship within species. However, more extensive molecular data are needed in order to reach a general conclusion about the relationship between jute genotypes. Key words: Jute, Polymorphism, Genetic diversity, RAPD D.O.I. 10.3329/ptcb.v17i2.3239 Plant Tissue Cult. & Biotech. 17(2): 183-191, 2007 (December)
Re-evaluation of Mature Seed-derived Callusing and Regeneration Potential of Nine Orchardgrass (Dactylis golomerata L.) Cultivars
Authors: Lee Sang-Hoon , Ahsan Nagib , Lee Ki-Won , Lee Dong-Gi , Alam Iftekhar , Kim Kyung-Hee , Park Choong-Hoon , Kim Ki-Yong , Lee Byung-Hyun 
Published: April 2011

A suitable callus induction and efficient regeneration protocol for orchardgrass (Dactylis golomerata L.) was developed. It consisted of 3 mg/l 2,4-D + 0.1 mg/l BA + 1 g/l CH + 300 mg/l L-proline + 40 mg/l L-cysteine + 30 g/l sucrose in MS showed the highest percentage of callus induction. Maltose exhibited better in regeneration than other types of carbon sources. Highest (71%) regeneration was obtained from N6 medium containing 1 mg/l 2,4-D + 3 mg/l BA + 1 g/l CH + 300 mg/l L-proline + 40 mg/l L-cysteine + 30 g/l maltose. Among the nine cultivars of orchardgrass (Dactylis golomerata L.), genotypic variation was observed in both callus induction and regeneration. Overall callus induction and regeneration rates were 23 - 73 and 17 - 71%, respectively. Key words: Dactylis golomerata, Orchardgrass, Mature seeds, Additives, Regeneration, Maltose. D.O.I. 10.3329/ptcb.v17i2.3240 Plant Tissue Cult. & Biotech. 17(2): 193-207, 2007 (December)
Avulsion fracture of tibial insertion of PCL - operative management and outcome
Authors: Ali M , Agrawal P , Katakdhond N , Arshadullah M 
Published: April 2011

There are controversies about the management of the PCL injuries among the Orthopaedic surgeons. We present our result of 14 cases that underwent surgical management for the avulsion fracture of the tibial insertion of the PCL. Open reduction and internal fixation of the avulsion fracture of the tibial insertion of the PCL were done and results were analyzed. The study group consisted of 13 males and 1 female; the mean age was 27 years. The avulsion fractures of more than 3 weeks old were excluded. The result showed that there were no instability in any of the patients and each patient obtained pain free, full range of movement for the affected knee within a mean follow-up period of 11 months. Therefore it is recommended to take up surgical management for avulsed PCL if presented within 3 weeks of injury.DOI: http://dx.doi.org/10.3329/pulse.v4i1.6957Pulse Vol.4 January 2010 p.14-15
Des rites autour de l'enfant mort : un être unique, des rites partagés avec les vivants
Authors: Biot Christian 
Published: April 2011

Résumé Des rites autour de l’enfant mort : un être unique, des rites partagés avec les vivants – Le décès d’un petit enfant (parfois même avant le terme attendu de l’accouchement) est un moment redoutable pour ses parents et pour ses proches. Devant ce bouleversement des projets et des espérances, que peut-on attendre des rites funéraires ? Quels rites peuvent-ils être mis en action ? A partir de l’expérience d’un groupe lyonnais relié à l’église catholique qui assure, dans les centres funéraires de la ville de Lyon, des célébrations religieuses et des célébrations civiles, nous proposons la réflexion suivante : évocation de la fonction sociale (souvent religieuse) des rites funéraires. Comment les rites se situent-ils entre le silence et le cri ? Regard sur quelques célébrations réalisées soit dans un contexte religieux, soit dans un contexte civil : qu’est-ce qui a guidé le choix des gestes, des prises de paroles, des textes ou de la musique ? Un temps d’échange avec les participants de la rencontre pour préciser la réflexion.
Un groupe de parole pour victimes de « sectes à deux »
Authors: Maes Jean-Claude , Bermudez Encarni , Deklippel Johanne , Hoeylaerts Véronique 
Published: April 2011

Résumé En 2007-2008, SOS-Sectes et le CCPFM ont eu l’occasion d’organiser des groupes de paroles pour ex-adeptes de « sectes à deux ». Une « secte à deux », c’est un couple avec un gourou et un adepte. L’objectif de ces groupes étant plus réflexif que purement cathartique, il en ressort une véritable théorie de l’emprise abusive dans le couple.
Les Catégories d'Aristote : instrument ou doctrine ?
Authors: Jaulin Annick 
Published: April 2011

Résumé Les catégories dégagées par Aristote sont-elles un instrument formel, ontologiquement neutre, comme pourrait le laisser penser l’usage propédeutique qu’en firent les néoplatoniciens dans leur cursus scolaire ? Si l’on refuse cette hypothèse, est-on contraint de donner aux catégories le statut d’êtres ? L’opposition même entre interprétation ontologique et interprétation formelle devrait être remise en question, car une grille formelle, comme l’est le schéma des catégories, lorsqu’elle possède un ordre, comme c’est le cas avec les catégories, ne saurait être ontologiquement neutre.
Peut-on connaître quelque chose de nouveau ? Variations médiévales sur l'argument du Ménon
Authors: Grellard Christophe 
Published: April 2011

Résumé Cet article cherche à préciser les modes d’appropriation médiévale du paradoxe du Ménon (80de) selon lequel il est impossible de rien apprendre, c’est-à-dire de connaître quelque chose de nouveau. Dans un premier temps, on met en évidence les vecteurs de transmission textuelle. Dans la mesure où le dialogue lui-même a été mal connu au Moyen Âge, c’est principalement par l’intermédiaire du résumé qu’en donne Aristote ( Seconds analytiques , 71 a30-b9) que le paradoxe et ses possibles solutions ont été appréhendés. Pour les commentateurs des Seconds analytiques au xiii e siècle ce paradoxe vient appuyer une conception innéiste de la science (la science est actualisation du virtuel) auquel est opposé un empirisme aristotélicien. Cette opposition est radicalisée par les nominalistes du xiv e siècle. La réfutation de l’argument de Ménon devient alors l’occasion de développer une conception strictement naturaliste de l’acquisition du savoir.
Repères pour penser le martyre chrétien
Authors: Donard Véronique 
Published: April 2011

Cet article propose des outils logiques et métapsychologiques pour comprendre la façon spécifiquement chrétienne de faire face à la mort et de témoigner de son adhésion à la figure et au message du Christ. La notion de martyre étant intimement liée à celle de sacrifice, il traite, dans une première partie, de la question d’un fantasme sacrificiel originaire, celui-ci à visée universelle. Une seconde partie est centrée sur le vécu chrétien et aborde le martyre en rendant compte de ce « style » de vie qu’est la sainteté, puis en tentant de comprendre en quoi la mort du Nazaréen a été comprise et interprétée par ses disciples comme un sacrifice. Cela permet d’expliquer pourquoi l’identification radicale à la figure du Christ peut être comprise comme une invitation à passer par ses mêmes souffrances. Cette étude se termine par une approche de la figure d’Ignace d’Antioche, martyrisé au début du premier siècle, prenant appui sur la lettre qu’il écrivit à la communauté chrétienne de Rome alors que, prisonnier, il faisait route vers la capitale pour y être exécuté.
Martyr(e) Témoin de vie ou témoin de mort ?
Authors: Courban Antoine 
Published: April 2011

Le martyr musulman, mort dans le cadre du combat spirituel pour Dieu, va directement au paradis ; il ne meurt pas. La félicité paradisiaque dont il bénéficie n’est pas la vision directe de Dieu qu’il ne peut pas voir. Il est « vu » par Dieu. Dans le martyre chrétien, c’est Dieu qui vient à la rencontre de l’homme. Dans l’islam, c’est l’homme qui va vers Dieu et qui conquiert, dans une sorte de projet prométhéen, la plénitude de sa propre ontologie. C’est donc un acte à caractère politique plus affirmé. Le phénomène du martyr-suicide contemporain n’est pas une spécificité islamique. Il se rencontre dans d’autres cultures religieuses comme chez les Sikhs. Par ailleurs, l’islam n’est pas un tout homogène. C’est dans le monde chiite préférentiellement, marqué par la révolution de Khomeiny où la notion de Malakut ( mundus imaginalis ) a une importance cruciale, que le martyr-suicide pourrait être compris comme un déicide symbolique fondateur d’un ordre politique. Comme témoin de mort, il rend témoignage pour la volonté de puissance, la libido dominandi , qui lui fait commettre l’auto-meurtre, non de soi, mais de cet Autre qui est en lui et qui l’empêcherait de devenir autonome. Comme témoin de vie, il rend témoignage de la pérennité de l’identité du groupe perçue comme une essence intemporelle. Sa mort est un moment de fondation de cette identité collective source des pires violences.
La passion de Husayn Mansûr Al-Hallaj
Authors: Ayouch Soraya 
Published: April 2011

Il est difficile de parler du martyr sans évoquer Al-Hallaj, l’un des plus grands mystiques musulmans, condamné à mort après un procès qui dura près de dix ans. Il fut le premier martyr mystique en Islam. Celui que Louis Massignon a fait découvrir dans une œuvre magistrale, La passion d’Al-Hallaj (Gallimard, Paris, 1975, 4 vol.), est aussi connu pour son œuvre poétique. Nous présentons Al-Hallaj, dans sa biographie, ses voyages et sa quête, mettant en relief des traits saillants de son histoire et de son itinéraire. Certains de ses textes mêlent la langue poétique à l’expérience mystique : « Ce qui compte pour l’extatique, c’est que l’Unique le réduise à l’unité » ; ou encore « va prévenir mes amis que je me suis embarqué pour la haute mer... C’est dans l’instance suprême de la croix que je mourrai. » Tous ces textes expliquent, amènent le fameux « Ana al haqq » de Hallâj (« je suis la Vérité, je suis Dieu ») qui avait choqué les théologiens et qui lui a valu l’expérience du martyre.
L'écrivain martyr dans le Léviathan de Paul Auster
Authors: Drossart Francis 
Published: April 2011

Le roman Léviathan de Paul Auster illustre de façon saisissante la manière dont l’écrivain, confronté à la destructivité et à la terreur sans nom véhiculées par le monde contemporain, trouve une issue sublimatoire au prix d’un clivage de sa personnalité. Ici, en l’occurrence, entre le premier écrivain, le narrateur (Peter) et son double (Ben), écrivain qui renonce à l’écriture pour se lancer dans l’action terroriste qui le conduira à la mort. La trajectoire de Ben, par un jeu hallucinant d’identifications projectives en cascade, étant infléchie par la mauvaise rencontre du terroriste Dimaggio, lui-même identifié (à moins qu’il ne soit un agent provocateur du FBI ?) au sujet de sa thèse d’Histoire, l’anarchiste Berkman. Le drame de la pensée concrète schizophrénique et de l’échec de la sublimation, trouve ici une résolution partielle, au prix du clivage de la personnalité de l’auteur entre ses parties détruites (Ben) et survivantes (Peter).
Enhanced Nerve–Mast Cell Interaction by a Neuronal Short Isoform of Cell Adhesion Molecule-1
Authors: Hagiyama Man , Furuno Tadahide , Hosokawa Yoichiroh , Iino Takanori , Ito Takeshi , Inoue Takao , Nakanishi Mamoru , Murakami Yoshinori , Ito Akihiko 
Published: April 2011

Abstract
Close apposition of nerve and mast cells is viewed as a functional unit of neuro-immune mechanisms, and it is sustained by trans-homophilic binding of cell adhesion molecule-1 (CADM1), an Ig superfamily member. Cerebral nerve–mast cell interaction might be developmentally modulated, because the alternative splicing pattern of four (a–d) types of CADM1 transcripts drastically changed during development of the mouse cerebrum: developing cerebrums expressed CADM1b and CADM1c exclusively, while mature cerebrums expressed CADM1d additionally and predominantly. To probe how individual isoforms are involved in nerve–mast cell interaction, Neuro2a neuroblastoma cells that express CADM1c endogenously were modified to express additionally either CADM1b (Neuro2a-CADM1b) or CADM1d (Neuro2a-CADM1d), and they were cocultured with mouse bone marrow-derived mast cells (BMMCs) and BMMC-derived cell line IC-2 cells, both of which expressed CADM1c. BMMCs were found to adhere to Neuro2a-CADM1d neurites more firmly than to Neuro2a-CADM1b neurites when the adhesive strengths were estimated from the femtosecond laser-induced impulsive forces minimally required for detaching BMMCs. GFP-tagging and crosslinking experiments revealed that the firmer adhesion site consisted of an assembly of CADM1d cis-homodimers. When Neuro2a cells were specifically activated by histamine, intracellular Ca2+ concentration was increased in 63 and 38% of CADM1c-expressing IC-2 cells that attached to the CADM1d assembly site and elsewhere, respectively. These results indicate that CADM1d is a specific neuronal isoform that enhances nerve–mast cell interaction, and they suggest that nerve–mast cell interaction may be reinforced as the brain grows mature because CADM1d becomes predominant.
Plasmacytoid Dendritic Cells Promote Host Defense against Acute Pneumovirus Infection via the TLR7–MyD88-Dependent Signaling Pathway
Authors: Davidson Sophia , Kaiko Gerard , Loh Zhixuan , Lalwani Amit , Zhang Vivian , Spann Kirsten , Foo Shen Yun , Hansbro Nicole , Uematsu Satoshi , Akira Shizuo , Matthaei Klaus I. , Rosenberg Helene F. , Foster Paul S. , Phipps Simon 
Published: April 2011

Abstract
Human respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection in infants. In human infants, plasmacytoid dendritic cells (pDC) are recruited to the nasal compartment during infection and initiate host defense through the secretion of type I IFN, IL-12, and IL-6. However, RSV-infected pDC are refractory to TLR7-mediated activation. In this study, we used the rodent-specific pathogen, pneumonia virus of mice (PVM), to determine the contribution of pDC and TLR7 signaling to the development of the innate inflammatory and early adaptive immune response. In wild-type, but not TLR7- or MyD88-deficient mice, PVM inoculation led to a marked infiltration of pDC and increased expression of type I, II, and III IFNs. The delayed induction of IFNs in the absence of TLR7 or MyD88 was associated with a diminished innate inflammatory response and augmented virus recovery from lung tissue. In the absence of TLR7, PVM-specific CD8+ T cell cytokine production was abrogated. The adoptive transfer of TLR7-sufficient, but not TLR7-deficient pDC to TLR7 gene-deleted mice recapitulated the antiviral responses observed in wild-type mice and promoted virus clearance. In summary, TLR7-mediated signaling by pDC is required for appropriate innate responses to acute pneumovirus infection. It is conceivable that as-yet–unidentified defects in the TLR7 signaling pathway may be associated with elevated levels of RSV-associated morbidity and mortality among otherwise healthy human infants.
Vitamin D and the Regulation of Placental Inflammation
Authors: Liu Nancy Q. , Kaplan Amber T. , Lagishetty Venu , Ouyang Yuxin B. , Ouyang Yi , Simmons Charles F. , Equils Ozlem , Hewison Martin 
Published: April 2011

Abstract
The vitamin D-activating enzyme 1α-hydroxylase (CYP27B1) and vitamin D receptor (VDR) support anti-inflammatory responses to vitamin D in many tissues. Given the high basal expression of CYP27B1 and VDR in trophoblastic cells from the placenta, we hypothesized that anti-inflammatory effects of vitamin D may be particularly important in this organ. Pregnant wild type (WT) mice i.p. injected with LPS showed elevated expression of mouse Cyp27b1 (4-fold) and VDR (6-fold). Similar results were also obtained after ex vivo treatment of WT placentas with LPS. To assess the functional impact of this, we carried out ex vivo studies using placentas −/− for fetal (trophoblastic) Cyp27b1 or VDR. Vehicle-treated −/− placentas showed increased expression of IFN-γ and decreased expression of IL-10 relative to +/+ placentas. LPS-treated −/− placentas showed increased expression of TLR2, IFN-γ, and IL-6. Array analyses identified other inflammatory factors that are dysregulated in Cyp27b1−/− versus Cyp27b1+/+ placentas after LPS challenge. Data highlighted enhanced expression of IL-4, IL-15, and IL-18, as well as several chemokines and their receptors, in Cyp27b1−/− placentas. Similar results for IL-6 expression were observed with placentas −/− for trophoblastic VDR. Finally, ex vivo treatment of WT placentas with the substrate for Cyp27b1, 25-hydroxyvitamin D3, suppressed LPS-induced expression of IL-6 and the chemokine Ccl11. These data indicate that fetal (trophoblastic) vitamin D plays a pivotal role in controlling placental inflammation. In humans, this may be a key factor in placental responses to infection and associated adverse outcomes of pregnancy.
Autoantibody-Mediated IL-6–Dependent Endothelin-1 Elevation Underlies Pathogenesis in a Mouse Model of Preeclampsia
Authors: Zhou Cissy Chenyi , Irani Roxanna A. , Dai Yingbo , Blackwell Sean C. , Hicks M. John , Ramin Susan M. , Kellems Rodney E. , Xia Yang 
Published: April 2011

AbstractPreeclampsia (PE) is a life-threatening hypertensive disorder of pregnancy. Elevated circulating endothelin-1 (ET-1) is associated with the disease. However the molecular basis of increased ET-1 production and its role in PE are unknown. This study aimed to investigate the causative factors, pathological role of elevated ET-1 production in PE, and the underlying mechanisms. In this study, we found that IgG from women with PE, in contrast to IgG from normotensive pregnant women, induced preproET-1 mRNA expression via angiotensin II type 1 receptor activation in kidneys and placentas in pregnant mice. The ET-A receptor-specific antagonist BQ123 significantly attenuated autoantibody-induced hypertension, proteinuria, and renal damage in pregnant mice, demonstrating that autoantibody-induced ET-1 production contributes to pathophysiology. Mechanistically, we discovered that IL-6 functioned downstream of TNF-α signaling, contributing to increased ET-1 production in pregnant mice. IL-6 blockade inhibited preeclamptic features in autoantibody-injected pregnant mice. Extending the data to human studies, we found that IL-6 was a key cytokine underlying ET-1 induction mediated by IgG from women with PE in human placental villous explants and that endothelial cells are a key source of ET-1. Overall, we provide human and mouse studies showing that angiotensin II type I receptor-agonistic autoantibody is a novel causative factor responsible for elevated ET-1 production and that increased TNF-α/IL-6 signaling is a key mechanism underlying increased ET-1 production and subsequent maternal features. Significantly, our findings revealed novel factors and signaling cascades involved in ET-1 production, subsequent disease symptom development, and possible therapeutic intervention in the management of PE.
Development of Science and Technology Parks in China, 1988–2008
Authors: Zhang Haiyang , Sonobe Tetsushi 
Published: April 2011

Abstract
In order to investigate the effectiveness of science and technology industrial parks (STIPs), this study examines data on high-tech firms within and outside the STIPs in China, while paying special attention to the issues related to agglomeration and congestion. The main finding is that the negative effect of congestion on productivity is highly likely to outweigh the positive productivity effect of agglomeration economies within the STIPs but not among hightech firms outside the STIPs. The paper also finds that the productivity of high-tech firms, whether within or outside the STIPs, are positively associated with foreign direct investment and the academic activities of local universities in the same city.