bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scientific note: Phoretic interaction between Antherophagus (Coleoptera) and Bombus funebris (Hymenoptera), using Chuquiraga jussieui (Asteraceae) as transfer stations in the páramos
Authors: Martel Carlos , Cifuentes Laura , Cuesta Francisco , Stevenson Philip C. , Tovar Carolina 
Published: May 2024

AbstractBeetles of the genus Antherophagus are phoretic organisms that inhabit the nests of Bombus species. They migrate and colonize new nests using the same bumblebees as carriers. Although Antherophagus beetles from temperate Europe and North America are known to use some plant species to move between bumblebees, it is unknown which plants are used as transfer stations by neotropical Antherophagus. Here, we report for the first time how phoretic Antherophagus beetles of an undescribed species use the inflorescences of Chuquiraga jussieui to transfer between individuals of Bombus funebris in the páramos of Central Ecuador. Our observations are the highest records (at 4200 m asl) of a phoretic interaction performed so far.
Unveiling the dynamics: how foreign aid shapes renewable energy, technology, globalization, and sustainable environments in BRICS nations
Authors: Siddiqui Faiza , Yusheng Kong , Kumari Sonia 
Published: May 2024

AbstractAlthough the existing literature on environmental sustainability (ES) emphasizes its importance, yet few empirical studies look at the major contributing variables to ES. Therefore, we examine how the use of renewable energy, globalization, and technological innovation (TI) contribute to ES, with the moderating influence of foreign aid, spanning the period from 1996 to 2019 in BRICS economies. For data analysis, we apply the ARDL methodology, revealing an adverse and substantial link among globalization, TI, and the consumption of renewable energy with ES. Additionally, we discover that foreign aid has a beneficial moderating effect on the association between ES, globalization, and TI. On the other hand, it is found that foreign aid has an adverse moderating impact on the link between renewable energy sources and ES. This research also yields crucial practical implications, offering in-depth insights for the design of more effective policies to foster economic growth.
RGG-PSO+: Random Geometric Graphs Based Particle Swarm Optimization Method for UAV Path Planning
Authors: Liu Yang , Zhu Xiaomin , Zhang Xiao-Yi , Xiao Jiannan , Yu Xiaohan 
Published: May 2024

AbstractEvolutionary algorithms, such as particle swarm optimization (PSO), are widely applied to UAV path planning problems. However, the fixed particle length of PSO, which may not be suitable for the scenario, will compromise the search efficiency. This paper proposes the RGG-PSO+ method, which adapts to scenarios by dynamically adjusting the number of waypoints. Random geometric graphs (RGG) and the divide-and-conquer paradigm are involved in improving the proposed method. Comparative analyses with established heuristic methods demonstrate RGG-PSO+’s superior performance in complex environments, particularly in terms of convergence speed and path length. The implementation of RGG significantly improves the F-Measure, indicating a shift from exploration to exploitation of PSO’s iterations, and the implementation of the divide-and-conquer paradigm is evident in the improved mean and variance of normalized path lengths.
Source Data Verification (SDV) quality in clinical research: A scoping review
Authors: Hamidi Muayad , Eisenstein Eric L. , Garza Maryam Y. , Morales Kayla Joan Torres , Edwards Erika M. , Rocca Mitra , Cramer Amy , Singh Gurparkash , Stephenson-Miles Kimberly A. , Syed Mahanaz , Wang Zhan , Lanham Holly , Facile Rhonda , Pierson Justine M. , Collins Cal , Wei Henry , Zozus Meredith 
Published: May 2024

Abstract

Introduction:
The value of Source Data Verification (SDV) has been a common theme in the applied Clinical Translational Science literature. Yet, few published assessments of SDV quality exist even though they are needed to design risk-based and reduced monitoring schemes. This review was conducted to identify reports of SDV quality, with a specific focus on accuracy.

Methods:
A scoping review was conducted of the SDV and clinical trial monitoring literature to identify articles addressing SDV quality. Articles were systematically screened and summarized in terms of research design, SDV context, and reported measures.

Results:
The review found significant heterogeneity in underlying SDV methods, domains of SDV quality measured, the outcomes assessed, and the levels at which they were reported. This variability precluded comparison or pooling of results across the articles. No absolute measures of SDV accuracy were identified.

Conclusions:
A definitive and comprehensive characterization of SDV process accuracy was not found. Reducing the SDV without understanding the risk of critical findings going undetected, i.e., SDV sensitivity, is counter to recommendations in Good Clinical Practice and the principles of Quality by Design. Reference estimates (or methods to obtain estimates) of SDV accuracy are needed to confidently design risk-based, reduced SDV processes for clinical studies.
Treatment Interruptions and Mortality Among Puerto Rican Women With Gynecologic Cancers in Puerto Rico After Hurricanes Irma and María: A Retrospective Cohort Study
Authors: Rivera-Gastón Fabiola A. , Umpierre-Catinchi Sharee , Ramos-Cartagena Jeslie M. , Ortiz-Ortiz Karen J. , Torres-Cintrón Carlos R. , García-Camacho Sandra I. , Calo William A. , Tortolero-Luna Guillermo , Martínez-Ocasio Liz M. , Ortiz Ana P. 
Published: May 2024

Abstract

Objective:
Cancer patients are among the most vulnerable populations during and after a disaster. We evaluated the impact of treatment interruption on the survival of women with gynecologic cancer in Puerto Rico following Hurricanes Irma and María.

Methods:
A retrospective cohort study among a clinic-based sample of women with gynecological cancer diagnosed between January 2016 and September 2017 (n = 112) was done. Women were followed from their diagnosis until December 2019, to assess vital status. Kaplan-Meier survival curves and Cox proportional hazards models were performed.

Results:
Mean age was 56 (± 12.3) years; corpus uteri (58.9%) was the most common gynecologic cancer. Predominant treatments were surgery (91.1%) and chemotherapy (44.6%). Overall, 75.9% were receiving treatment before the hurricanes, 16.1% experienced treatment interruptions, and 8.9% died during the follow-up period. Factors associated with treatment interruption in bivariate analysis included younger age (≤55 years), having regional/distant disease, and receiving > 1 cancer treatment (P < 0.05). Crude analysis revealed an increased risk of death among women with treatment interruption (HR: 3.88, 95% CI: 1.09-13.77), persisting after adjusting for age and cancer stage (HR: 2.49, 95% CI: 0.69-9.01).

Conclusions:
Findings underscore the detrimental impact of treatment interruption on cancer survival in the aftermath of hurricanes, emphasizing the need for emergency response plans for this vulnerable population.
F. A. Hayek, Libertarianism, and the Denationalization of Money
Authors: McIntosh Whitney 
Published: May 2024

AbstractAmid the inflation crisis of the 1970s, the Austrian School economist F. A. Hayek presented a radical proposal to solve inflation: the denationalization of currency and the introduction of competing currencies into the monetary system. While Hayek's proposal proved too radical for mainstream economists, Hayek found support within the American libertarian movement. Libertarians realized that Hayek's radical proposal would limit state control over the monetary system and allow for the free exchange of gold. Even though libertarians were not immediately successful in bringing Hayek's plan to fruition, their continued activism paved the way for the creation of cryptocurrency in 2009. This article demonstrates how Hayek and his libertarian supporters opened a new chapter in the history of the “money question” in the United States by advocating for the elimination of the government monopoly over money and the abolition of monetary politics itself.
‘Who can tell me what potable water means?’ The assessment of water quality in debates over hydraulic infrastructure in nineteenth-century Italy
Authors: Valenti Salvatore 
Published: May 2024

Abstract
How water is perceived and represented has an impact on the relationships between a given society and its water infrastructure. Historians have identified a shift in the perception of water during the nineteenth century, which was connected to the development of chemistry. From an understanding based in Hippocratic medicine and natural history that treated it as an infinite variety of substances, water eventually became understood as a simple compound consisting of oxygen and hydrogen. This resulted in the abstraction of water from its social and environmental contexts, with consequences for the way water was managed. This article aims to demonstrate that such a view gives a mistaken intellectual coherence to a fragmented and conflicted process, which involved continuities, an adaptation of old frameworks to new social priorities, and fine changes in scientific thinking and practices. This paper examines the scientific and political debates concerning water infrastructure, surveys and analyses on water quality, medical reports and political measures in nineteenth-century Italy. Ultimately, the reduction of ‘waters’ to ‘water’ in Italy was more about determining who had the authority to assess water quality in the process of creating and stabilizing new power relations between the public and the private spheres than about the abstraction of water from its social and environmental contexts.
Novelty seeking might underlie curiosity and the novelty dimension of creativity, but not the usefulness dimension
Authors: Acar Oguz A. , Fuchs Christoph 
Published: May 2024

Abstract
We question the perspective that curiosity and creativity stem from a shared novelty-seeking process. We emphasize that creativity has two distinct dimensions: Novelty and usefulness, each involving separate cognitive processes. These dimensions may not necessarily mutually reinforce each other. We contend that a more comprehensive model that encompasses the full scope of the creativity construct is needed.
Curious? The relationship between curiosity and creativity is likely NOT novelty
Authors: Jirout Jamie J. , Evans Natalie S. , Hirsh-Pasek Kathy 
Published: May 2024

Abstract
The target article tackles an important and complicated issue of the underlying links between curiosity and creativity. Although thought-provoking, the target article overlooks contemporary theories and research on these constructs. Consequently, the proposed model is inconsistent with prior research in the developmental and educational fields and would benefit from better specification and clarity around key constructs and processes.
Models need mechanisms, but not labels
Authors: Prasad Seema , Hommel Bernhard 
Published: May 2024

Abstract
The target article proposes a model involving the important but not well-investigated topics of curiosity and creativity. The model, however, falls short of providing convincing explanations of the basic mechanisms underlying these phenomena. We outline the importance of mechanistic thinking in dealing with the concepts outlined in this article specifically and within psychology and cognitive neuroscience in general.
Is a wandering mind a novelty-seeking mind? The curious case of incubation
Authors: Faber Myrthe , de Rooij Alwin 
Published: May 2024

Abstract
The Novelty-Seeking Model can explain incubation's effect on creativity by assuming an adaptive decision threshold. During an impasse, the threshold for novelty becomes too high and biased to previous neural activity, hindering progress. Incubation “resets” this threshold through attentional decoupling, allowing for spontaneous ideas to emerge from subsequent mind wandering or other activities that attract attention, facilitating progress.
An extension of the novelty-seeking model: Considering the plurality of novelty types and their differential interactions with memory
Authors: Servais Anaïs , Bastin Christine 
Published: May 2024

Abstract
The novelty-seeking model suggests that curiosity and creativity originate from novelty processes. However, different types of novelty exist, each with distinctive relationships with memory, which potentially influence curiosity and creativity in distinct ways. We thus propose expanding the NSM model to consider these different novelty types and their specific involvement in creativity.
Ignoring the role of reiterative processing and worldview transformation leads to exaggeration of the role of curiosity in creativity
Authors: Gabora Liane , Ganesh Kirthana , Bashmakova Iana 
Published: May 2024

Abstract
The Novelty-Seeking Model does not address the iterative nature of creativity, and how it restructures one's worldview, resulting in overemphasis on the role of curiosity, and underemphasis on inspiration and perseverance. It overemphasizes the product; creators often seek merely to express themselves or figure out or come to terms with something. We point to inconsistencies regarding divergent and convergent thought.
Prediction error minimization as a common computational principle for curiosity and creativity
Authors: Becker Maxi , Cabeza Roberto 
Published: May 2024

Abstract
We propose expanding the authors’ shared novelty-seeking basis for creativity and curiosity by emphasizing an underlying computational principle: Minimizing prediction errors (mismatch between predictions and incoming data). Curiosity is tied to the anticipation of minimizing prediction errors through future, novel information, whereas creative AHA moments are connected to the actual minimization of prediction errors through current, novel information.
A shared novelty-seeking basis for creativity and curiosity: Response to the commentators
Authors: Ivancovsky Tal , Baror Shira , Bar Moshe 
Published: May 2024

Abstract
In our target article, we proposed that curiosity and creativity are both manifestations of the same novelty-seeking process. We received 29 commentaries from diverse disciplines that add insights to our initial proposal. These commentaries ultimately expanded and supplemented our model. Here we draw attention to five central practical and theoretical issues that were raised by the commentators: (1) The complex construct of novelty and associated concepts; (2) the underlying subsystems and possible mechanisms; (3) the different pathways and subtypes of curiosity and creativity; (4) creativity and curiosity “in the wild”; (5) the possible link(s) between creativity and curiosity.
Legal Pluralism as a Category of Analysis
Authors: Marglin Jessica , Letteney Mark 
Published: May 2024

AbstractA debate has raged for decades over legal pluralism and its value for the study of law. Much of this back and forth has resolved to a fight over what law “is” and push-and-pull between legal centrists and pluralists. This introductory essay proposes a new framework for thinking about legal pluralism. Turning away from the centrist/pluralist binary, we instead ask what work legal pluralism as a category of analysis can do. The debate, we suggest, is a fundamental methodological disagreement about the normative work that categories of analysis do and the costs that historians should be willing to pay to reap the benefits of theoretically sophisticated frameworks of analysis which are interoperable between times and places. The debate about legal pluralism, we argue, can be productively reframed as a question about the benefits and drawbacks of the legal pluralist framework.
Before the Dressel 20: pottery workshops and olive oil amphorae of the Guadalquivir valley between the Late Republic and Augustan-Tiberian times
Authors: González Cesteros Horacio , García Vargas Enrique , González Tobar Iván , Berni Millet Piero , Almeida Rui Roberto de 
Published: May 2024

AbstractThe Baetican Dressel 20 is probably the most widely diffused amphora of the Roman period, found in large quantities throughout all the Roman and nearby territories. It is the most powerful evidence of the importance of the olive oil trade for Roman society and of olive oil's extraordinary production in the Baetican countryside. This wide diffusion of the amphora and, in some ways, its ubiquity at many archaeological sites, have hindered the study of the early stages of Baetican olive oil production and diffusion. The protagonists were not these spherical containers, commonly stamped up until the late 3rd c. CE, but previous models that evolved rapidly after their origins in Late Republican times. In this paper, we aim to analyze not only the formal characteristics and evolution of these peculiar and still unstandardized containers, but also other aspects linked to their production, as well as the scope of their diffusion.
Recent insights into the therapeutic strategies targeting the pseudokinase PTK7 in cancer
Authors: Dessaux Charlotte , Ganier Laetitia , Guiraud Louis , Borg Jean-Paul 
Published: May 2024

AbstractThe generation of drugs counteracting deregulated protein kinases has been a major focus in cancer therapy development. Breakthroughs in this effort have produced many therapeutic agents to the benefit of patients, mostly through the development of chemical or antibody-based drugs targeting active kinases. These strategies are challenged when considering catalytically inactive protein kinases (or pseudokinases), which represent 10% of the human kinome with many of relevance in cancer. Among the so-called pseudotyrosine kinases, the PTK7 receptor tyrosine kinase (RTK) stands as a bona fide target overexpressed in several solid tumors and hematological malignancies and linked to metastasis, poor prognosis, and resistance to treatment. Despite the lack of catalytic activity, PTK7 has signaling capacities through heterodimerization with active RTKs and offers pharmacological targeting opportunities through its inactive kinase domain. Moreover, PTK7-targeting strategies based on antibody-drug conjugates, aptamers, and CAR-T cell-based therapies have demonstrated encouraging results in preclinical and clinical settings. We review the most recent data assigning to PTK7 a prominent role in cancer progression as well as current preclinical and clinical targeting strategies against RTK family pseudokinases including PTK7.
Safety and efficacy of narsoplimab in pediatric and adult patients with transplant-associated thrombotic microangiopathy: a real-world experience
Authors: Castelli Marta , Micò Maria Caterina , Grassi Anna , Algarotti Alessandra , Lussana Federico , Finazzi Maria Chiara , Rambaldi Benedetta , Pavoni Chiara , Rizzuto Giuliana , Tebaldi Paola , Vendemini Francesca , Verna Marta , Bonanomi Sonia , Biondi Andrea , Balduzzi Adriana , Rambaldi Alessandro , Gotti Giacomo 
Published: May 2024

AbstractTransplant-associated thrombotic microangiopathy (TA-TMA) is a severe complication following hematopoietic stem cell transplantation (HSCT). No approved treatments are currently available. This study presents real-world data obtained with narsoplimab, a human immunoglobulin G4 monoclonal antibody that inhibits MASP-2, the effector enzyme of the lectin pathway of the complement system. Between January 2018 and August 2023, 20 (13 adult and 7 pediatric) patients diagnosed with TA-TMA received narsoplimab under an ongoing compassionate use program. The diagnosis was based on internationally defined criteria for pediatric and adult patients. Fifteen patients fulfilled the criteria recently established by an international consensus on TA-TMA. Nineteen patients exhibited high-risk characteristics. Thirteen patients (65%) responded to narsoplimab, achieving transfusion independence and significant clinical improvement. The one-hundred-day Overall Survival (OS) post-TA-TMA diagnosis was 70%, and 100% for responders. Narsoplimab proved to be effective and safe in the treatment of high-risk TA-TMA, with no increased infectious complications or other safety signals of concern across all age groups. The high response rates and the encouraging survival outcomes underscore the potential of narsoplimab as a valuable therapeutic option, particularly for high-risk cases.
Orexin neurons track temporal features of blood glucose in behaving mice
Authors: Viskaitis Paulius , Tesmer Alexander L. , Liu Ziyu , Karnani Mahesh M. , Arnold Myrtha , Donegan Dane , Bracey Eva , Grujic Nikola , Patriarchi Tommaso , Peleg-Raibstein Daria , Burdakov Denis 
Published: May 2024

AbstractDoes the brain track how fast our blood glucose is changing? Knowing such a rate of change would enable the prediction of an upcoming state and a timelier response to this new state. Hypothalamic arousal-orchestrating hypocretin/orexin neurons (HONs) have been proposed to be glucose sensors, yet whether they track glucose concentration (proportional tracking) or rate of change (derivative tracking) is unknown. Using simultaneous recordings of HONs and blood glucose in behaving male mice, we found that maximal HON responses occur in considerable temporal anticipation (minutes) of glucose peaks due to derivative tracking. Analysis of >900 individual HONs revealed glucose tracking in most HONs (98%), with derivative and proportional trackers working in parallel, and many (65%) HONs multiplexed glucose and locomotion information. Finally, we found that HON activity is important for glucose-evoked locomotor suppression. These findings reveal a temporal dimension of brain glucose sensing and link neurobiological and algorithmic views of blood glucose perception in the brain’s arousal orchestrators.
Parenteral platforms for tunable, long-acting administration of a highly hydrophobic antiretroviral drug
Authors: Akhavein Nima , Baum Marc M. , Gunawardana Manjula , Moss John A. , Calvez Sandrine , Remedios-Chan Mariana , Fanter Rob , Lenhard Steve , Rusk Samantha , Azzarano Leonard , McCoy Deborah , Jucker Beat , Johns Brian , Burke Matt , Velthuisen Emile 
Published: May 2024

AbstractGSK2838232 (GSK8232) is a second-generation maturation inhibitor (MI) developed for the treatment of HIV with excellent broad-spectrum virological profiles. The compound has demonstrated promising clinical results as an orally administered agent. Additionally, the compound’s physical and pharmacological properties present opportunities for exploitation as long-acting parenteral formulations. Despite unique design constraints including solubility and dose of GSK8232, we report on three effective tunable drug delivery strategies: active pharmaceutical ingredient (API) suspensions, ionic liquids, and subdermal implants. Promising sustained drug release profiles were achieved in rats with each approach. Additionally, we were able to tune drug release rates through a combination of passive and active strategies, broadening applicability of these formulation approaches beyond GSK8232. Taken together, this report is an important first step to advance long-acting formulation development for critical HIV medicines that do not fit the traditional profile of suitable long-acting candidates.