bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemokine receptor CXCR4 signaling modulates the growth factor‐induced cell cycle of self‐renewing and multipotent neural progenitor cells
Authors: Li Meizhang , Chang Cathleen J. , Lathia Justin D. , Wang Li , Pacenta Holly L. , Cotleur Anne , Ransohoff Richard M. 
Published: November 2010

AbstractCXC chemokine receptor CXCR4 is expressed in vitro in both human and rodent adult neural progenitor cells (NPCs). It has been suggested that the CXCL12‐CXCR4 axis potentially enhances the proliferation of NPCs. However, whether CXCR4 is expressed in the neural stem cells (NSCs), a subset of self‐renewing and multipotent NPCs, and whether CXCR4 signaling is directly required for their proliferation are not clear. In this study, we report that CXCR4 is expressed in a subpopulation of NPCs in the early embryonic ventricular zone. In studies of a CXCR4eGFP bacterial artificial chromosomal (BAC) transgenic mouse line, we further isolated NPCs from E12.5 transgenic telencephalon and GFP+ cells demonstrated self‐renewal and multipotency in neurosphere assays in vitro. Consistent with these observations, we enriched GFP+/CXCR4+ cells by fluorescence activated cell sorting (FACS) with either CXCR4 antibody 12G5 or GFP. Furthermore, we observed that CXCL12 alone did not activate the self‐renewal of NPCs or increase the proliferation of NPCs that are induced by bFGF/EGF. However, we found that blocking CXCR4 receptor with antagonist AMD3100 impaired the bFGF/EGF‐induced expansion of GFP+ NPCs through modulating their cell cycling. In addition, AMD3100 treatment of pregnant mice reduced the generation of neurospheres from E12.5 embryos. Our data suggest that CXCR4 is a potential cell surface marker for early embryonic NSCs and modulates growth‐factor signaling. © 2010 Wiley‐Liss, Inc.
Glial solute carrier transporters in drosophila and mice
Authors: Featherstone David E. 
Published: November 2010

AbstractGlia regulate brain physiology primarily by regulating the movement and concentration of substances in the extracellular fluid. Therefore, one approach to understanding the role of glia in brain physiology is to study what happens when glial transporters are removed or modified. The largest and most highly conserved class of transporter is solute carrier (SLC) proteins. SLC proteins are highly expressed in brain, and many are found in glia. The function of many SLC proteins in the brain—particularly in glia—is very poorly understood. SLC proteins can be relatively easily knocked out or modified in genetic model organisms to better understand glial function. Drosophila are popular genetic model organisms that offer a nice balance between genetic malleability and brain complexity. They are ideal for such an endeavor. This article lists and discusses SLC transporter family members that are expressed in both mouse and Drosophila glia, in an effort to provide a foundation for studies of glial SLC transporters using Drosophila as a model. © 2010 Wiley‐Liss, Inc.
Quantifying the Stacking Registry Matching in Layered Materials
Authors: Hod Oded 
Published: November 2010

AbstractA detailed account of a recently developed method [Marom et al., Phys. Rev. Lett. 2010, 105, 046801] to quantify the registry mismatch in layered materials is presented. The registry index, which was originally defined for planar hexagonal boron‐nitride, is extended to treat graphitic systems and generalized to describe multi‐layered nanotubes. It is shown that, using simple geometric considerations, it is possible to capture the complex physical features of interlayer sliding in layered materials. The intuitive nature of the presented model and the efficiency of the related computations suggest that the method can be used as a powerful characterization tool for interlayer interactions in complex layered systems.
Theoretical Studies of Inorganic Fullerenes and Fullerene‐Like Nanoparticles
Authors: Enyashin Andrey N. 
Published: November 2010

AbstractThe present review provides a comprehensive overview of the theoretical understanding of inorganic, non‐carbon fullerenes and fullerene‐like particles. Special emphasis is placed on the description of structure, stability, and electronic, magnetic, and mechanical properties of layered compounds — hexagonal boron nitride, metal sulfides, and chlorides.
Knowledge competence in clinical and counseling training and readiness for internship
Authors: Stedman James M. , Schoenfeld Lawrence S. 
Published: November 2010

AbstractThe concept of competence has become the driving force in the education and training of professional psychologists. In fact, competence has evolved into increasingly sophisticated forms, now perhaps best represented by the cube model, which integrates foundational, functional, and developmental variables into ideas about professional training. This article considers one component of professional training, scientific knowledge, and argues that knowledge competence, measured by the Examination for Professional Practice in Psychology, should occur before a student is certified as internship ready. © 2010 Wiley Periodicals, Inc. J Clin Psychol 00:1–5, 2010.
A One‐Stop Approach to the Management of Soft Tissue and Degenerative Musculoskeletal Conditions Using Clinic‐Based Ultrasonography
Authors: Sivan Manoj , Brown James , Brennan Stephen , Bhakta Bipin 
Published: November 2010

AbstractBackground and objective. One‐stop clinics aim at assessment, investigation and initiating treatment in a single hospital visit. They have been proven to be cost‐effective and to increase patient satisfaction in various specialties. The aim of this study was to describe the one‐stop approach to managing soft tissue and degenerative musculoskeletal conditions using clinic‐based musculoskeletal ultrasonography (MSUS).Methods. A retrospective case record review was carried out of patients assessed and managed in the musculoskeletal clinic by a musculoskeletal and sports physician over a 10‐month period.Results. A total of 1,166 patients were assessed and managed in a total of 155 outpatient clinics. The age range of patients was 19 to 85 years (median age 45 years). The diagnoses included traumatic or overuse tendinopathy, degenerative arthritis, bursitis, acute/chronic sporting injuries and acute/chronic back pain. A total of 1,012 patients (87%) had conditions related to the appendicular system (shoulder girdle, upper limb, pelvic girdle and lower limb) and 154 patients were referred with spinal pain. All patients with appendicular system problems had a definite diagnosis and treatment initiated on the first visit to the clinic. In 658 (65%) patients, a diagnostic ultrasound was deemed an appropriate investigation to improve the accuracy of diagnosis and more than half of them (352 patients) needed ultrasound‐guided injections as part of the management of their conditions. A portable GE Healthcare LOGIQe machine with a 10 MHz linear probe and colour Doppler flow imaging was used to perform all scans. No adverse incidents were reported.Conclusions. The use of clinic‐based MSUS enables a one‐stop approach, reduces repeated hospital appointments and improves quality of care in an outpatient musculoskeletal clinic. Copyright © 2010 John Wiley & Sons, Ltd.
Electron‐state control of hexagonal boron nitride: Carrier injection into inter‐layer band
Authors: Okada Susumu , Otani Minoru 
Published: November 2010

AbstractBy using the local density approximation in density functional theory, we study the electronic structure of hexagonal boron nitride (h‐BN) intercalation compounds in which lithium atoms are intercalated into the interlayer spacing. We find that the electronic structure of lithium‐intercalated h‐BN under equilibrium interlayer distance is metallic, in which electrons are injected into a nearly free electron state.The calculated Fermi surfaces of the compound possesses circular shape around the Γ point and are similar to that of alkali/alkali‐earth metal‐doped graphite intercalation compounds (GICs) (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Broadband light source using modulated quantum dot structures with sandwiched sub‐nano separator (SSNS) technique
Authors: Yamamoto Naokatsu , Akahane Kouichi , Kawanishi Tetsuya , Sotobayashi Hideyuki , Fujioka Hiroki , Takai Hiroshi 
Published: November 2010

AbstractA broadband light source for a wavelength range of around 1.2‐1.3 μm can be fabricated using a multi‐stacked and modulated InAs/InGaAs quantum dot (QD) structure with the sandwich sub‐nano separator (SSNS) technique. These techniques, such as use of the modulated QD structure and SSNS structure, are considered useful in obtaining a high‐quality and ultra‐broadband QD optical gain material for the laser and/or optical amplifier. A broadband (>75 nm bandwidth) and bright (few tenths of a mW) light emission in its waveband is successfully demonstrated from a QD laser diode using a modulated QD optical gain with the SSNS technique. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Introducing dopants by diffusion to improve the conductivity of silicon quantum dot materials in 3rd generation photovoltaic devices
Authors: Ma Linzhi , Lin Dong , Conibeer Gavin , Perez‐Wurfl Ivan 
Published: November 2010

AbstractAn alternative method to introduce dopants in Silicon rich oxide (SRO) layers was investigated. A silicon dioxide (SiO2) layer containing phosphorous pentoxide (P2O5) or boron (B) was deposited on the quartz substrate. A bilayer structure was subsequently deposited using Si and SiO2. SRO layers were doped via diffusion during the high temperature annealing required to form the Silicon quantum dot (Si‐QD) materials. Two kinds of dopants (phosphorus and boron) were introduced as they are typical dopants for n‐type and p‐type Si respectively. The annealing time was also varied to achieve an optimum conductivity of the quantum dot material. Different Si concentrations in the SRO layers were investigated. A 5% change of Si concentration could change the conductivity of the Si‐QD material by more than one order of magnitude. Using circular transmission line measurement (TLM), the sheet resistivity of the Si‐QD material was extracted. It was demonstrated that this new method of introducing dopants by diffusion is successful. Moreover, it was found that the conductivity of Si‐QD materials decreased with increasing Si concentration in the SRO layers and was also influenced by the type of dopants. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Phase‐matching properties of BaGa4S7 and BaGa4Se7: Wide‐bandgap nonlinear crystals for the mid‐infrared
Authors: Badikov Valeriy , Badikov Dmitrii , Shevyrdyaeva Galina , Tyazhev Aleksey , Marchev Georgi , Panyutin Vladimir , Petrov Valentin , Kwasniewski Albert 
Published: November 2010

AbstractBiaxial BaGa4S7 and BaGa4Se7 crystals transparent in the mid‐IR have been grown by the Bridgman–Stockbarger technique in sufficiently large sizes and with good optical quality to measure the refractive indices and analyze phase‐matching properties. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
The effect of diet and feeding level on survival and weight gain of hand‐raised harbor seal pups (Phoca vitulina)
Authors: MacRae A.M. , Haulena M. , Fraser D. 
Published: November 2010

AbstractHundreds of stranded harbor seals pups (Phoca vitulina) are brought to wildlife rescue centers every year. Typical hand‐rearing diets include artificial milk‐replacers and diets based on macerated fish fed via gavage, but weight gains are often low and mortality rates can be high. This study compared survival and weight gain of orphaned seal pups fed either artificial milk‐replacer or fish‐formula. Pups admitted to the facility in summer 2007 (n=145) and 2008 (n=98) were randomly assigned to one of two diets and fed by gavage until weaning. In 2007, pups fed milk‐replacer gained more (43±12 g/d) than those fed fish‐formula (loss of 13±6 g/d; P<0.002). In 2008, when intake was increased from 8 to 11% of body weight daily, weight gain improved for both diets but remained higher in pups fed milk‐replacer (123±12 g/d, vs. loss of 6±8 g/day; P<0.001). Pup survival to weaning was significantly higher in 2008 than 2007 (P<0.001) and was higher for pups on milk‐replacer compared with those on fish‐formula (P<0.05). Survival was also correlated with body weight at admittance (P<0.001). Although neither diet achieved the weight gains recorded in mother‐raised pups (400–800 g/d), the artificial milk‐replacer was clearly more successful, and pups fared better in the second year of the study when intake was higher. Zoo Biol 30:532–541, 2011. © 2010 Wiley Periodicals, Inc.
Pancreatic transplantation: surgical technique, normal radiological appearances and complications
Authors: Hampson Frances A. , Freeman Susan J. , Ertner Julia , Drage Martin , Butler Andrew , Watson Chris J. , Shaw Ashley S. 
Published: November 2010

Abstract
Pancreas transplantation is a surgical treatment for diabetes mellitus. More than 23,000 pancreas transplants have now been reported to the International Transplant Registry (IPTR). Early diagnosis and therapy for graft-related complications are essential for graft survival. Radiologists must therefore understand the surgical procedure and the potential complications. During the course of this review, we will illustrate the normal post-operative anatomy and the imaging appearances of common potential complications.
Midge-transmitted bluetongue in domestic dogs
Authors: OURA C. A. L. , EL HARRAK M. 
Published: November 2010

SUMMARYThe role of domestic dogs in the long-distance spread of bluetongue virus (BTV) remains unproven. It is currently known that dogs are capable of being infected with BTV, can mount an antibody response to the virus and in some cases die showing severe clinical signs of disease. Infection of dogs is currently thought to be by oral ingestion of infected meat or meat products rather than through vector feeding. In this study we show that a high percentage of domestic dogs in Morocco (21%) were seropositive for BTV and, as these dogs were fed tinned commercial food only, and had no access to other meat products, the most likely source of infection was through Culicoides midges. This finding increases the chances of dogs being infected with BTV during an outbreak but their role in the onward transmission of BTV remains unproven.
The Juno Mission
Authors: Bolton S. J. ,   the Juno Science Team
Published: November 2010

AbstractJuno is the next NASA New Frontiers mission which will launch in August 2011. The mission is a solar powered spacecraft scheduled to arrive at Jupiter in 2016 and be placed into polar orbit around Jupiter. The goal of the Juno mission is to explore the origin and evolution of the planet Jupiter. Juno's science themes include (1) origin, (2) interior structure, (3) atmospheric composition and dynamics, and (4) polar magnetosphere and aurora. A total of nine instruments on-board provide specific measurements designed to investigate Juno's science themes. The primary objective of investigating the origin of Jupiter includes 1) determine Jupiter's internal mass distribution by measuring gravity with Doppler tracking, 2) determine the nature of its internal dynamo by measuring its magnetic fields with a magnetometer, and 3) determine the deep composition (in particular the global water abundance) and dynamics of the sub-cloud atmosphere around Jupiter, by measuring its thermal microwave emission.
Observing Mercury: from Galileo to the stereo camera on the BepiColombo mission
Authors: Cremonese Gabriele , Da Deppo Vania , Naletto Giampiero , Martellato Elena , Debei Stefano , Barbieri Cesare , Bettanini Carlo , Capria Maria T. , Massironi Matteo , Zaccariotto Mirko 
Published: November 2010

AbstractAfter having observed the planets from his house in Padova using his telescope, in January 1611 Galileo wrote to Giuliano de Medici that Venus is moving around the Sun as Mercury. Forty years ago, Giuseppe Colombo, professor of Celestial Mechanics in Padova, made a decisive step to clarify the rotational period of Mercury. Today, scientists and engineers of the Astronomical Observatory of Padova and of the University of Padova, reunited in the Center for Space Studies and Activities (CISAS) named after Giuseppe Colombo, are busy to realize a stereo camera (STC) that will be on board the European (ESA) and Japanese (JAXA) space mission BepiColombo, devoted to the observation and exploration of the innermost planet. This paper will describe the stereo camera, which is one of the channels of the SIMBIOSYS instrument, aiming to produce the global mapping of the surface with 3D images.
Functional annotation of human parvovirus b19 proteome and Molecular docking of VP1 protein with Teniposide
Authors: Praneetha Amburu , Pradhan Dibyabhaba , Priyadarshini Vani , Umamaheswari Amineni 
Published: November 2010

AbstractParvovirus B19 is a common source of infection with a seroprevalence of 60-70% in the adult population. Human parvovirus causes several distinct clinical syndromes such as erythema, polyarthritis resembling rheumatoid arthritis, vasculitis, hydrops fetalis, myocarditis etc. Recent years have witnessed manifest increase in clinical knowledge of parvovirus B19-associated complications, diagnosis and treatment. Traditional immunosuppressive therapy being unsuccessful, anti-viral therapy might be worthy of consideration. Functional annotation of human parvoviral proteome may provide insights into role of viral proteome in its survival and pathogenic mechanisms. Availability of whole proteome in the open source aided functional annotation of protein using SVMprot. Protein functions common to both structural and non-structural proteins are metal -binding, lipid-binding, copper-binding, calcium-binding, zinc-binding, magnesium-binding, DNA-binding, RNA-binding, transmembrane and outer membrane group of proteins. VP1 protein of human parvovirus b19 being quiet important for its structural integrity and being non homologous to human proteome, was identified as an attractive molecular target for structure based drug discovery. 3D structure of target protein VP1protein is predicted based on VP2 protein from human parvovirus b19 using MODELLER9V6. The modeled structure is validated using PROCHECK. Binding sites were predicted in Discovery studio 2.0 and Teniposide was found to be best docked lead molecule among selected ligands those docked to the functionally important site 1 using LigandFit protocol. The docking complex shows teniposide forming strong hydrogen bond with serine 580 of modeled VP1 protein. The strong hydrogen bonding, hydrophobic interaction, Vander wall interaction marked by teniposide would affect the structural integrity of parvovirus B19 significantly. The detailed insight of structural, functional and interactive aspect of the protein is being studied would enable us delineate it as potential drug target. Also different docking poses generated through docking studies may be considered as a model for identifying drug candidate against parvovirus.
Nonexponential decay of internal rotational correlation functions of native proteins and self-similar structural fluctuations
Authors: Cote Yoann , Senet Patrick , Delarue Patrice , Maisuradze Gia G. , Scheraga Harold A. 
Published: November 2010

Structural fluctuations of a protein are essential for the function of native proteins and for protein folding. To understand how the main chain in the native state of a protein fluctuates on different time scales, we examined the rotational correlation functions (RCFs),
C
(
t
), of the backbone N-H bonds and of the dihedral angles γ built on four consecutive
C

α

atoms. Using molecular dynamics simulations of a model
α
/
β
protein (VA3) in its native state, we demonstrate that these RCFs decay as stretched exponentials, ln[
C
(
t
)] ≈
D

α

t

α

with a constant
D

α

and an exponent α (0 <
α
< 0.35) varying with the free-energy profiles (FEPs) along the amino acid sequence. The probability distributions of the fluctuations of the main chain computed at short time scale (1 ps) were identical to those computed at large time scale (1 ns) if the time is rescaled by a factor depending on
α
< 1. This self-similar property and the nonexponential decays (
α
≠ 1) of the RCFs are described by a rotational diffusion equation with a time-dependent diffusion coefficient
D
(
t
) =
αD

α

t

α
-1

. The present findings agree with observations of subdiffusion (
α
< 1) of fluorescent probes within a protein molecule. The subdiffusion of
15
N-H bonds did not affect the value of the order parameter
S
2
extracted from the NMR relaxation data by assuming normal diffusion (
α
= 1) of
15
N-H bonds on a nanosecond time scale. However, we found that the RCF does not converge to
S
2
on the nanosecond time scale for residues with multiple-minima FEPs.
A Mutation in ArabidopsisSEEDLING PLASTID DEVELOPMENT1Affects Plastid Differentiation in Embryo-Derived Tissues during Seedling Growth
Authors: Ruppel Nicholas J. , Logsdon Charles A. , Whippo Craig W. , Inoue Kentaro , Hangarter Roger P. 
Published: November 2010

AbstractOilseed plants like Arabidopsis (Arabidopsis thaliana) develop green photosynthetically active embryos. Upon seed maturation, the embryonic chloroplasts degenerate into a highly reduced plastid type called the eoplast. Upon germination, eoplasts redifferentiate into chloroplasts and other plastid types. Here, we describe seedling plastid development1 (spd1), an Arabidopsis seedling albino mutant capable of producing normal green vegetative tissues. Mutant seedlings also display defects in etioplast and amyloplast development. Precocious germination of spd1 embryos showed that the albino seedling phenotype of spd1 was dependent on the passage of developing embryos through the degreening and dehydration stages of seed maturation, suggesting that SPD1 is critical during eoplast development or early stages of eoplast redifferentiation. The SPD1 gene was found to encode a protein containing a putative chloroplast-targeting sequence in its amino terminus and also domains common to P-loop ATPases. Chloroplast localization of the SPD1 protein was confirmed by targeting assays in vivo and in vitro. Although the exact function of SPD1 remains to be defined, our findings reveal aspects of plastid development unique to embryo-derived cells.
ArabidopsisTyrosylprotein Sulfotransferase Acts in the Auxin/PLETHORA Pathway in Regulating Postembryonic Maintenance of the Root Stem Cell Niche
Authors: Zhou Wenkun , Wei Lirong , Xu Jian , Zhai Qingzhe , Jiang Hongling , Chen Rong , Chen Qian , Sun Jiaqiang , Chu Jinfang , Zhu Lihuang , Liu Chun-Ming , Li Chuanyou 
Published: November 2010

AbstractRecent identification of the Arabidopsis thaliana tyrosylprotein sulfotransferase (TPST) and a group of Tyr-sulfated peptides known as root meristem growth factors (RGFs) highlights the importance of protein Tyr sulfation in plant growth and development. Here, we report the action mechanism of TPST in maintenance of the root stem cell niche, which in the Arabidopsis root meristem is an area of four mitotically inactive quiescent cells plus the surrounding mitotically active stem cells. Mutation of TPST leads to defective maintenance of the root stem cell niche, decreased meristematic activity, and stunted root growth. We show that TPST expression is positively regulated by auxin and that mutation of this gene affects auxin distribution by reducing local expression levels of several PIN genes and auxin biosynthetic genes in the stem cell niche region. We also show that mutation of TPST impairs basal- and auxin-induced expression of the PLETHORA (PLT) stem cell transcription factor genes and that overexpression of PLT2 rescues the root meristem defects of the loss-of-function mutant of TPST. Together, these results support that TPST acts to maintain root stem cell niche by regulating basal- and auxin-induced expression of PLT1 and PLT2. TPST-dependent sulfation of RGFs provides a link between auxin and PLTs in regulating root stem cell niche maintenance.