bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physical and compositional characteristics of drinking water storage tank sediment
Authors: Lytle Darren A. , Muhlen Christy , Lippitt Scott H. , Crockett Evan , Achtemeier Riley 
Published: May 2024

AbstractThirty‐one drinking water storage tank sediment samples were collected in 13 states, 17 distribution systems, and 29 tanks over the course of 4 years. Sediment samples were characterized for elemental composition and physical properties, which were found to be inconsistent both between samples of the same distribution system and across geographical regions. Differences between samples from the same tank also indicated spatial differences in sediment composition within storage tanks. Color was found to qualitatively trend toward darker or lighter depending on the concentration of a few elements (iron, aluminum, calcium, and magnesium). Particle shape varied between samples though uniformity increased as the particle size decreased. The average sediment particle density in this study (1.99 g/cm3) was lower than the density of a widely used sediment resuspension model silica sand (2.65 g/cm3), possibly resulting in underestimation of resuspension in models. This study suggests that sediment properties are highly site and storage tank specific, necessitating individual characterization to achieve greatest accuracy in storage tank suspension and draining model inputs.
Framing sustainability strategies for the enactment of corporate actions with positive macro‐level impact: Evidence from a developing country
Authors: Rodríguez Jorge A. , Amaya‐Rivas Adriana 
Published: May 2024

AbstractThe literature on sustainability strategies has focused on outcomes at the micro or meso level of analysis, such as changes in the indicators of people, organizations, or supply chains. However, sustainable development involves a set of macro‐level issues such as the atmosphere, oceans, and societal phenomena. There is scarce research linking business actions to planetary‐ or national‐level outcomes. Therefore, this research focuses on how the process of framing a sustainability strategy shapes the enactment of social or environmental actions with an intended positive macro‐level impact. We use five longitudinal case studies in Ecuador to create a framework that links the framing of sustainability strategies with the enactment of actions with a positive macro‐level impact. This research finds that sustainability strategies framed as environmental impacts following science‐based methods, and integrative cross‐sector partnerships mobilize explorative sustainable innovation capabilities and partnerships for collective actions with macro‐level impacts. We also find that temporal ambidextrous management, purpose alignment, and perceived competence in monitoring resource allocation are enablers of the transition of these framing processes. Finally, managers should be aware that macro‐level impacts are more likely to be generated through collective actions and innovation efforts deployed using ecosystem logic for value creation.
An open‐source data acquisition platform for teaching vibration analysis
Authors: Trujillo‐Franco Luis G. , Abundis‐Fong Hugo F. , Marin‐Soriano Juan C. 
Published: May 2024

AbstractThe actual open‐source hardware and software tools offer a rich set of options for developing didactic tools to improve the teaching–learning process of various areas of engineering. Using low‐cost sensors, in conjunction with free software development tools, allows the creation of educational interfaces and platforms offering very acceptable performance and precision that help the student to become familiar with the basic principles that govern professional equipment. In this work, we propose a low‐cost system for data acquisition specially designed to improve the learning experience of experimental mechanics. To achieve this purpose, we use open‐source software and hardware tools to create a piece of educational equipment that is fully configurable for different sensors. We present the experimental results of two case studies: the vibration analysis of a rotor‐bearing system using acceleration signals and a free‐vibration study using a xylophone and a low‐cost microphone. The proposed platform helps authors to complement a 4‐month course named Vibration, intended for mechanical engineering students. The students who participated in the study demonstrated an improvement in their comprehension of vibration theory and modal analysis using the finite element technique. The feedback from students indicates that 84% of the participants are highly motivated to learn more about vibrations and experimental mechanics.
Berberine: Potential preventive and therapeutic strategies for human colorectal cancer
Authors: Feng Yuqian , Lu Jiamin , Jiang Jing , Wang Menglei , Guo Kaibo , Lin Shengyou 
Published: May 2024

AbstractColorectal cancer (CRC) is a common digestive tract tumor, with incidences continuing to rise. Although modern medicine has extended the survival time of CRC patients, its adverse effects and the financial burden cannot be ignored. CRC is a multi‐step process and can be caused by the disturbance of gut microbiome and chronic inflammation's stimulation. Additionally, the presence of precancerous lesions is also a risk factor for CRC. Consequently, scientists are increasingly interested in identifying multi‐target, safe, and economical herbal medicine and natural products. This paper summarizes berberine's (BBR) regulatory mechanisms in the occurrence and development of CRC. The findings indicate that BBR regulates gut microbiome homeostasis and controls mucosal inflammation to prevent CRC. In the CRC stage, BBR inhibits cell proliferation, invasion, and metastasis, blocks the cell cycle, induces cell apoptosis, regulates cell metabolism, inhibits angiogenesis, and enhances chemosensitivity. BBR plays a role in the overall management of CRC. Therefore, using BBR as an adjunct to CRC prevention and treatment could become a future trend in oncology.
Immobilization of Oleate Hydratase on Solid Supports
Authors: Oike Keiko , Schoevaart Rob , Hollmann Frank , Hanefeld Ulf , Hagedoorn Peter‐Leon 
Published: May 2024

AbstractOleate hydratases open a biocatalytic access to hydroxy fatty acids by hydration of unsaturated fatty acids. Their practical applicability, however, is hampered by their low stability. In this study we report the immobilization of the oleate hydratase from Rhodococcus erythropolis PR4 on functionalized porous, spherical polymer beads. Different carrier materials promoting covalent, hydrophobic, ionic and his‐tag affinity were screened and immobilization yields typically >95 % were observed. The highest activity recovery of 32 % was achieved by immobilization via ionic interaction with quaternary ammonium functionalized beads. Biochemical properties of the enzyme immobilized via ionic interaction remain unchanged upon immobilization. The immobilized enzyme was applied for synthesis of 10‐hydroxystearic acid remaining stable under process conditions. Conversion of up to 100 mM oleic acid gave 10‐hydroxystearic acid achieving a TON of up to 19,000. Successful recycling of the biocatalyst for up to ten cycles further demonstrate its potential for the synthesis of 10‐hydroxystearic acid.
Recent Progress in Thermally Activated Delayed Fluorescence Photosensitizers for Photodynamic Therapy
Authors: Li Ziqi , Lu Jianjun , Li Xuping 
Published: May 2024

AbstractPhotodynamic therapy (PDT) is a rapidly growing discipline that is expected to become an encouraging noninvasive therapeutic strategy for cancer treatment. In the PDT process, an efficient intersystem crossing (ISC) process for photosensitizers from the singlet excited state (S1) to the triplet excited state (T1) is critical for the formation of cytotoxic reactive oxygen species and improvement of PDT performance. Thermally activated delayed fluorescence (TADF) molecules featuring an extremely small singlet–triplet energy gap and an efficient ISC process represent an enormous breakthrough for the PDT process. Consequently, the development of advanced TADF photosensitizers has become increasingly crucial and pressing. The most recent developments in TADF photosensitizers aimed at enhancing PDT efficiency for bio‐applications are presented in this review. TADF photosensitizers with water dispersibility, targeting ability, activatable ability, and two‐photon excitation properties are highlighted. Furthermore, the future challenges and perspectives of TADF photosensitizers in PDT are proposed.
Direct Comparative Studies Revealing the Contribution of TADF Activity of Organic Emitters Towards Efficient Electrochemiluminescence
Authors: Wei Jinliu , Yang Nairong , Li Feiming , Cai Shunyou , Zhang Baohua , Cai Zhixiong 
Published: May 2024

AbstractElectrochemiluminescence (ECL) featuring thermally activated delayed fluorescence (TADF) properties has attracted considerable interest, showcasing their potential for 100 % exciton harvesting, which marks a significant advancement in the realm of organic ECL. However, the challenge of elucidating the precise contribution of TADF to the enhanced ECL efficiency arises due to the lack of comparative studies of organic compounds with or without efficient TADF properties. In this study, we present four carbazole‐benzonitrile molecules possessing similar chemical structures and comparable exchange energy (ΔEST). Despite their comparable properties, these compounds exhibited varying TADF efficiencies, warranting a closer examination of their underlying structural and electronic characteristics governing the optical properties. Consequently, intense ECL emission was only observed from 4CzBN with a remarkable TADF efficiency, underscoring the substantial difference in the ECL signal among molecules with comparable ΔEST and similar spectral properties but varying TADF activity.
Indium(III)‐Catalyzed Haloalkynylation Reaction of Alkynes
Authors: Daniels Alyssa , Wölper Christoph , Haberhauer Gebhard 
Published: May 2024

AbstractGreen chemistry strives for sustainability at the molecular level and is gaining increasing relevance in the development of chemical reactions. The haloalkynylation reaction is a highly atom–economical C−C coupling reaction that was previously only achieved using transition metal catalysts. It enables the introduction of an alkyne unit and a halogen atom into the target molecule. Herein, we present a haloalkynylation reaction catalyzed by indium(III) halides. The use of indium(III) bromide as a catalyst leads exclusively to the cis addition products with yields up to 86 %. In addition, iodoacetylenes can be applied for the first time for the haloalkynylation reaction of internal alkynes which is an important step forward in the development of industrially relevant and sustainable catalysts. In contrast to gold catalysis, which proceeds via a similar mechanism, the use of alkyl‐substituted haloacetylenes as reagents is also possible. Based on 13C labeling experiments and quantum chemical calculations, we postulate two possible mechanisms for the indium(III)‐catalyzed haloalkynylation reactions.
Photoinduced Perfluoroalkyloximation of Alkenes with Simple Perfluoroalkyl Halides
Authors: Li Wei , Li Zhongji , Zhong Deliang , Wang Nianxing , Li Huaifeng 
Published: May 2024

Comprehensive SummaryIn this paper, the difunctionalizative perfluoroalkyloximation of alkenes has been developed for the first time. This photochemical method allows for the synthesis of various perfluoroalkyl ethanone oximes with excellent regioselectivity and good functional group tolerance. Our method employs the most common perfluoroalkyl source, perfluoroalkyl iodides, as Rf reagents. Besides long‐chain perfluoroalkyl groups, this approach could be extended to incorporating additional groups, including trifluoromethyl, difluoromethyl, sulfonyl, and malonate, selectively into olefins, resulting in a range of β‐substituted ethanone oximes. Notably, the potential of this method in the Fukuyama indole synthesis, generating novel 2‐perfluoroalkylated 3‐(α‐oximidobenzyl)indoles via a radical cascade mechanism with 2‐vinylphenylacryloyl isocyanate as the radical acceptor, presents a compelling avenue for drug synthesis. The protocol is efficient, scalable, and useful for late‐stage modification of bioactive molecules.
Asymmetric Transfer Hydrogenation of Stable NH Imines for the Synthesis of Enantiopure α‐Chiral Primary Amines
Authors: Zhang Mangang , Li Hui , Wu Keqin , Rong Nianxin , Lin Shaoquan , Yang Hua , Yin Qin 
Published: May 2024

Comprehensive SummaryAlthough it offers a direct route to access synthetically valuable α‐chiral primary amines, asymmetric transfer hydrogenation of NH imines has been rarely studied, due in large part to the inaccessibility and instability of NH imines. Herein, we report a Rh‐catalyzed asymmetric transfer hydrogenation of a kind of novel and stable NH imines which are prepared via condensation of easily available sulfonylated 2’‐aminoacetophenones with NH3 in methanol. With this method, enantioenriched chiral 2‐(1‐aminoalkyl)anilines, which are privileged pharmacore groups, have been synthesized with good functional group compatibility, and with up to 99% ee. A gram‐scale reaction using 0.2 mol% of catalyst has been successfully performed to highlight the practicality. Furthermore, the products can be derivatized into enantiopure bioactive molecules as well as chiral tridentate ligands for metal catalysis.
Complications of transcatheter paravalvular leak device closure of mitral valve: An updated review of the literature and a rare case presentation
Authors: Jenab Yaser , Nourian Saeed , Hosseini Mohammadi Negin Sadat , Mohseni‐Badalabadi Reza , Hosseini Kaveh , Zakavi Sarina , Ates Ismail 
Published: May 2024

AbstractParavalvular leak (PVL) is an uncommon complication of prosthetic valve implantation, which can lead to infective endocarditis, heart failure, and hemolytic anemia. Surgical reintervention of PVLs is associated with high mortality rates. Transcatheter PVL closure (TPVLc) has emerged as an alternative to surgical reoperation. This method provides a high success rate with a low rate of complications. This article reviews the pathogenesis, clinical manifestation, diagnosis, and management of PVL and complications following TPVLc. Besides, we presented a case of a patient with severe PVL following mitral valve replacement, who experienced complete heart block (CHB) during TPVLc. The first TPVLc procedure failed in our patient due to possible AV‐node insult during catheterization. After 1 week of persistent CHB, a permanent pacemaker was implanted. The defect was successfully passed using the previous attempt. Considering the advantages of TPVLc, procedure failure should be regarded as a concern. TPVLc should be performed by experienced medical teams in carefully selected patients.
Early detection and prognosis evaluation for hepatocellular carcinoma by circulating tumour DNA methylation: A multicentre cohort study
Authors: Guo De‐Zhen , Huang Ao , Wang Ying‐Chao , Zhou Shuang , Wang Hui , Xing Xiang‐Lei , Zhang Shi‐Yu , Cheng Jian‐Wen , Xie Ke‐Hui , Yang Qi‐Chang , Ma Cheng‐Cheng , Li Qing , Chen Yan , Su Zhi‐Xi , Fan Jia , Liu Rui , Liu Xiao‐Long , Zhou Jian , Yang Xin‐Rong 
Published: May 2024

AbstractBackgroundEarly diagnosis of hepatocellular carcinoma (HCC) can significantly improve patient survival. We aimed to develop a blood‐based assay to aid in the diagnosis, detection and prognostic evaluation of HCC.MethodsA three‐phase multicentre study was conducted to screen, optimise and validate HCC‐specific differentially methylated regions (DMRs) using next‐generation sequencing and quantitative methylation‐specific PCR (qMSP).ResultsGenome‐wide methylation profiling was conducted to identify DMRs distinguishing HCC tumours from peritumoural tissues and healthy plasmas. The twenty most effective DMRs were verified and incorporated into a multilocus qMSP assay (HepaAiQ). The HepaAiQ model was trained to separate 293 HCC patients (Barcelona Clinic Liver Cancer (BCLC) stage 0/A, 224) from 266 controls including chronic hepatitis B (CHB) or liver cirrhosis (LC) (CHB/LC, 96), benign hepatic lesions (BHL, 23), and healthy controls (HC, 147). The model achieved an area under the curve (AUC) of 0.944 with a sensitivity of 86.0% in HCC and a specificity of 92.1% in controls. Blind validation of the HepaAiQ model in a cohort of 523 participants resulted in an AUC of 0.940 with a sensitivity of 84.4% in 205 HCC cases (BCLC stage 0/A, 167) and a specificity of 90.3% in 318 controls (CHB/LC, 100; BHL, 102; HC, 116). When evaluated in an independent test set, the HepaAiQ model exhibited a sensitivity of 70.8% in 65 HCC patients at BCLC stage 0/A and a specificity of 89.5% in 124 patients with CHB/LC. Moreover, HepaAiQ model was assessed in paired pre‐ and postoperative plasma samples from 103 HCC patients and correlated with 2‐year patient outcomes. Patients with high postoperative HepaAiQ score showed a higher recurrence risk (Hazard ratio, 3.33, p < .001).ConclusionsHepaAiQ, a noninvasive qMSP assay, was developed to accurately measure HCC‐specific DMRs and shows great potential for the diagnosis, detection and prognosis of HCC, benefiting at‐risk populations.
Histologic, metabolomic, and transcriptomic differences in fir trees from a peri‐urban forest under chronic ozone exposure
Authors: Reyes‐Galindo Verónica , Jaramillo‐Correa Juan P. , Shishkova Svetlana , Sandoval‐Zapotitla Estela , Flores‐Ortiz César Mateo , Piñero Daniel , Spurgin Lewis G. , Martin Claudia A. , Torres‐Jardón Ricardo , Zamora‐Callejas Claudio , Mastretta‐Yanes Alicia 
Published: May 2024

AbstractUrbanization modifies ecosystem conditions and evolutionary processes. This includes air pollution, mostly as tropospheric ozone (O3), which contributes to the decline of urban and peri‐urban forests. A notable case are fir (Abies religiosa) forests in the peripheral mountains southwest of Mexico City, which have been severely affected by O3 pollution since the 1970s. Interestingly, some young individuals exhibiting minimal O3—related damage have been observed within a zone of significant O3 exposure. Using this setting as a natural experiment, we compared asymptomatic and symptomatic individuals of similar age (≤15 years old; n = 10) using histologic, metabolomic, and transcriptomic approaches. Plants were sampled during days of high (170 ppb) and moderate (87 ppb) O3 concentration. Given that there have been reforestation efforts in the region, with plants from different source populations, we first confirmed that all analyzed individuals clustered within the local genetic group when compared to a species‐wide panel (Admixture analysis with ~1.5K SNPs). We observed thicker epidermis and more collapsed cells in the palisade parenchyma of needles from symptomatic individuals than from their asymptomatic counterparts, with differences increasing with needle age. Furthermore, symptomatic individuals exhibited lower concentrations of various terpenes (ß‐pinene, ß‐caryophylene oxide, α‐caryophylene, and ß‐α‐cubebene) than asymptomatic trees, as evidenced through GC–MS. Finally, transcriptomic analyses revealed differential expression for 13 genes related to carbohydrate metabolism, plant defense, and gene regulation. Our results indicate a rapid and contrasting phenotypic response among trees, likely influenced by standing genetic variation and/or plastic mechanisms. They open the door to future evolutionary studies for understanding how O3 tolerance develops in urban environments, and how this knowledge could contribute to forest restoration.
May brood desertion be ruled by partner parenting capability in a polygamous songbird? An experimental study
Authors: Zheng Jia , Wang Hui , Jiang Jiayao , Versteegh Maaike A. , Zhou Zhuoya , Zhang Zhengwang , Chen De , Komdeur Jan 
Published: May 2024

AbstractParents confront multiple aspects of offspring demands and need to coordinate different parental care tasks. Biparental care is considered to evolve under circumstances where one parent is not competent for all tasks and cannot efficiently raise offspring. However, this hypothesis is difficult to test, as uniparental and biparental care rarely coexist. Chinese penduline tits (Remiz consobrinus) provide such a system where both parental care types occur. Here, we experimentally investigated whether parents in biparental nests are less capable of caring than parents in uniparental nests. We monitored parenting efforts at (1) naturally uniparental and biparental nests and (2) biparental nests before and during the temporary removal of a parent. Given the relatively small sample sizes, we have employed various statistical analyses confirming the robustness of our results. We found that total feeding frequency and brooding duration were similar for natural uniparental and biparental nests. Feeding frequency, but not brooding duration, contributed significantly to nestling mass. In line with this, a temporary parental removal revealed that the remaining parents at biparental nests fully compensated for the partner's feeding absence but not for brooding duration. This reflects that the manipulated parents are confronted with a trade‐off between feeding and brooding and were selected to invest in the more influential one. However, such a trade‐off may not occur in parents of natural uniparental care nests. The different capabilities of a parent independently coordinating feeding and brooding tasks suggest that parents from biparental and uniparental nests were exposed to different resource conditions, thereby foraging efficiency may differ between care types.
Determinants of taxonomic, functional, and phylogenetic beta diversity in breeding birds within urban remnant woodlots: Implications for conservation
Authors: Liu Yu , Zhu Yun , Wu Su , Wang Yan , Xie Jie , Zhang Kai , Xu Yu 
Published: May 2024

AbstractExamining beta diversity of animal assemblages in fragmented habitats, which measures variation in species composition among different fragments, is important for understanding the impact of habitat fragmentation on biodiversity. However, relying solely on taxonomic composition may not provide a comprehensive understanding. Incorporating measures of functional and phylogenetic diversities is essential for elucidating the ecological mechanisms underlying changes in community composition. In addition, prevailing studies often prioritize the evaluation of landscape characteristics within fragments as determinants of beta diversity, neglecting differences in habitat type and plant community composition. In this study, we surveyed birds in 26 remnant woodlot patches (ranging from 0.3 to 290.4 ha) in an urban landscape, southwest China, during the breeding season from 2017 to 2022. We recorded 70 bird species (excluding those recorded only once and high‐flying birds, including raptors, swallows, and swifts), with the number of species per patch varying from 14 to 56. The overall bird taxonomic and phylogenetic beta diversities were primarily contributed by the turnover component, while functional beta diversity was dominated by the nestedness‐resultant component. Patch area and perimeter area ratio significantly influenced the taxonomic, functional, and phylogenetic beta diversities, primarily mediated through the nestedness‐resultant component, while inter‐patch distance had a significant effect via the turnover component. In addition, there was a considerable correlation of bird taxonomic, functional, and phylogenetic beta diversities with habitat type and woody plant beta diversities, including their respective partitioned turnover and nestedness‐resultant components. Our results suggest that bird assemblages in these patches may be regulated by selective extinction, interspecific competition, and environmental filtering. The findings have significant implications for sustainable landscape planning and habitat restoration. Conserving habitat patches of different sizes and maintaining or enhancing habitat heterogeneity between patches can facilitate the persistence of metacommunities.