bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exoplanet host star classification: multi-objective optimization of incomplete stellar abundance data
Authors: Zammit Miguel A , Borg Josef , Zarb Adami Kristian 
Published: June 2024

Abstract
The presence of a planetary companion around its host star has been repeatedly linked with stellar properties, affecting the likelihood of substellar object formation and stability in the protoplanetary disc, thus presenting a key challenge in exoplanet science. Furthermore, abundance and stellar parameter data sets tend to be incomplete, which limits the ability to infer distributional characteristics harnessing the entire data set. This work aims to develop a methodology using machine learning (ML) and multi-objective optimization for reliable imputation for subsequent comparison tests and host star recommendation. It integrates fuzzy clustering for imputation and ML classification of hosts and comparison stars into an evolutionary multi-objective optimization algorithm. We test several candidates for the classification model, starting with a binary classification for giant planet hosts. Upon confirmation that the eXtreme Gradient Boosting algorithm provides the best performance, we interpret the performance of both the imputation and classification modules for binary classification. The model is extended to handle multilabel classification for low-mass planets and planet multiplicity. Constraints on the model’s use and feature/sample selection are given, outlining strengths and limitations. We conclude that the careful use of this technique for host star recommendation will be an asset to future missions and the compilation of necessary target lists.
Performance of clinical and histological prognostic scores for kidney survival in ANCA-associated vasculitis
Authors: Sandino-Bermúdez Marlon J , Hernández-Andrade Adriana , Hinojosa-Azaola Andrea , Martín-Nares Eduardo , Mejía-Vilet Juan M 
Published: June 2024

Abstract

Objectives
Integrating clinical and histological parameters into prognostic scores may enhance the prediction of progression to kidney failure in anti-neutrophil cytoplasm antibodies-associated vasculitis (AAV). This study aimed to evaluate the prognostic performance of histological classifications and scoring systems for kidney survival in AAV.

Methods
This retrospective cohort study included 101 AAV patients with kidney involvement diagnosed by biopsy and followed for ≥12 months. The main outcome was the time to kidney failure. The prognostic performance of each histological and prognostic score was evaluated using Harrell’s C statistic and Akaike’s Information Criteria.

Results
Among the 101 patients, 37 progressed to kidney failure over a median follow-up of 75 months (IQR 39–123). The Harrell’s C statistic was 0.702 (0.620–0.784), 0.606 (0.473–0.738), 0.801 (0.736–0.867), 0.782 (0.706–0.858) and 0.817 (0.749–0.885) for the EUVAS/Berden classification, Mayo Clinic Chronicity Score, Percentage of ANCA Crescentic Score (PACS), ANCA renal risk score (ARRS), and the improved ANCA kidney risk score (AKRiS), respectively. The AKRiS best discriminated the risk of kidney failure progression among subgroups. The AKRiS performance decreased with longer follow-up intervals. Adding the peak estimated glomerular filtration rate attained post-therapy improved the AKRiS performance at all follow-up intervals. Kidney relapses precipitated kidney failure in 71% of cases that progressed after the first year of follow-up.

Conclusion
The novel AKRiS enhances the prediction of kidney failure in AAV with kidney involvement. As the prognostic yield of AKRiS decreases over time, a second calculation of AKRiS, including post-therapy kidney function, may improve its long-term performance.
An adapted transdiagnostic sleep and circadian intervention for adults with excess weight and suboptimal sleep health: pilot study results
Authors: Imes Christopher C , Kline Christopher E , Patel Sanjay R , Sereika Susan M , Buysse Daniel J , Harvey Allison G , Burke Lora E 
Published: June 2024

Abstract

Study Objectives
This single-arm, mixed-methods, pilot study examined the feasibility and preliminary efficacy of an adapted version of the transdiagnostic intervention for sleep and circadian dysfunction (TranS-C) on multidimensional sleep health (MDSH) in a sample of adults with excess weight and suboptimal sleep health.

Methods
Participants received up to eight, weekly, remotely delivered, tailored TranS-C sessions. At pre- and post-intervention, the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, and 7 days of Fitbit data were used to evaluate changes in sleep dimensions (regularity, alertness, timing, satisfaction, duration, and efficiency) and the composite MDSH score. Study feasibility examined recruitment, data collection, and intervention engagement (completion of core TranS-C sessions). Acceptability of the intervention was assessed with semi-structured interviews, which were analyzed using thematic analysis.

Results
From 85 referrals, 11 individuals were eligible, and 10 completed the study. All intervention participants completed the measures needed to calculate their composite MDSH score and completed the core intervention sessions. Themes from interviews support the intervention’s remote delivery approach, applicability of the information provided, and impact on self-reported health. The intervention resulted in a large improvement in the mean composite MDSH score (Cohen’s d = 1.17). Small-to-large effects were also observed for individual sleep health dimensions except for timing.

Conclusions
Adapted TranS-C is acceptable for adults with excess weight and suboptimal sleep health and may be effective at improving short-term MDSH. With changes to recruitment methods, a larger study is feasible. Limitations include the small sample size and the lack of a control condition.
Utility of CT Scans for Detecting Operative Malleolar Fractures Associated With Tibial Shaft Fractures
Authors: Nedder Victoria J. , Moon Tyler J. , Swetz Anna M. , Ochenjele George , Wetzel Robert J. , Sontich John K. , Napora Joshua K. 
Published: June 2024

OBJECTIVES:
The purpose of this study was to define the utility of CT scans for detecting articular extension in tibial shaft fractures and determine whether radiographic parameters can predict the presence of operative distal tibial articular fractures (DTAFs).

METHODS:

Design:
Retrospective cohort study.

Setting:
Single level I trauma center.

Patient Selection Criteria:
Patients age 18 years and older who were treated operatively for tibial shaft fractures occurring at or below the tibial isthmus were included. Patients were excluded for extension of the main tibial shaft fracture into the tibial plafond (AO/OTA 43 B/C), ballistic injuries, and absence of a preoperative CT scan.

Outcome Measures and Comparisons:
The primary outcome was CT utility, defined as the presence of a DTAF or DTAF displacement on CT that was not recognized on plain radiographs on secondary analysis at the time of the study by a senior-level resident. Secondary outcome was the association between radiographic parameters and operative DTAFs. Variables with P ≤ 0.2 on univariate testing were included in a multiple binary logistic regression model to determine independent predictors of operative DTAFs.

RESULTS:
One hundred forty-four patients were included, with a mean age of 52 years. Seventy-six patients (53%) were men. CT utility was 41% for the identification of unrecognized DTAFs. CT utility was 79% for isolated pDTAF, 57% for medial DTAF, 83% for isolated anterolateral DTAF, and 100% for multiple DTAFs. Operative DTAFs were independently associated with spiral tibial shaft fracture type (P < 0.001) and low fibular fracture (P = 0.04). In patients who had both spiral tibial shaft fracture type and low fibula fracture, the rate of operative DTAF was 46% (22/48).

CONCLUSIONS:
CT scans identified DTAFs that were unrecognized on plain radiographs in 41% of cases. CT scans were most useful in identifying nonposterior DTAFs. CT scans may be considered for all distal third tibial fractures, but especially those with spiral tibial shaft patterns and low fibular fractures, to avoid missing operative articular injury.

LEVEL OF EVIDENCE:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Global assessment of military and civilian trauma systems integration: a scoping review
Authors: Baird Michael D. , Madha Emad S. , Arnaouti Matthew , Cahill Gabrielle L. , Hewa Kodikarage Sadeesh N. , Harris Rachel E. , Murphy Timothy P. , Bartel Megan C. , Rich Elizabeth L. , Pathirana Yasar G. , Kim Eungjae , Bain Paul A. , Alswaiti Ghassan T. , Ratnayake Amila S. , Worlton Tamara J. , Joseph Michelle N. ,   IMPACT Scoping Review Group
Published: June 2024

Background:
The global burden of trauma disproportionately affects low-income countries and middle-income countries (LMIC), with variability in trauma systems between countries. Military and civilian healthcare systems have a shared interest in building trauma capacity for use during peace and war. However, in LMICs it is largely unknown if and how these entities work together. Understanding the successful integration of these systems can inform partnerships that can strengthen trauma care. This scoping review aims to identify examples of military-civilian trauma systems integration and describe the methods, domains, and indicators associated with integration including barriers and facilitators.

Methods:
A scoping review of all appropriate databases was performed to identify papers with evidence of military and civilian trauma systems integration. After manuscripts were selected for inclusion, relevant data was extracted and coded into methods of integration, domains of integration, and collected information regarding indicators of integration, which were further categorized into facilitators or barriers.

Results:
Seventy-four studies were included with authors from 18 countries describing experiences in 23 countries. There was a predominance of authorship and experiences from High-Income Countries (91.9 and 75.7%, respectively). Five key domains of integration were identified; Academic Integration was the most common (45.9%). Among indicators, the most common facilitator was administrative support and the lack of this was the most common barrier. The most common method of integration was Collaboration (50%).

Conclusion:
Current evidence demonstrates the existence of military and civilian trauma systems integration in several countries. High-income country data dominates the literature, and thus a more robust understanding of trauma systems integration, inclusive of all geographic locations and income statuses, is necessary prior to development of a framework to guide integration. Nonetheless, the facilitators identified in this study describe the factors and environment in which integration is feasible and highlight optimal indicators of entry.
Peripheral nerve transfers for dysfunctions in central nervous system injuries: a systematic review
Authors: Xiang Yun-Ting , Wu Jia-Jia , Ma Jie , Xing Xiang-Xin , Zhang Jun-Peng , Hua Xu-Yun , Zheng Mou-Xiong , Xu Jian-Guang 
Published: June 2024

Background:
The review highlights recent advancements and innovative uses of nerve transfer surgery in treating dysfunctions caused by central nervous system (CNS) injuries, with a particular focus on spinal cord injury (SCI), stroke, traumatic brain injury, and cerebral palsy.

Methods:
A comprehensive literature search was conducted regarding nerve transfer for restoring sensorimotor functions and bladder control following injuries of spinal cord and brain, across PubMed and Web of Science from January 1920 to May 2023. Two independent reviewers undertook article selection, data extraction, and risk of bias assessment with several appraisal tools, including the Cochrane Risk of Bias Tool, the JBI Critical Appraisal Checklist, and SYRCLE’s ROB tool. The study protocol has been registered and reported following PRISMA and AMSTAR guidelines.

Results:
Nine hundred six articles were retrieved, of which 35 studies were included (20 on SCI and 15 on brain injury), with 371 participants included in the surgery group and 192 in the control group. These articles were mostly low-risk, with methodological concerns in study types, highlighting the complexity and diversity. For SCI, the strength of target muscle increased by 3.13 of Medical Research Council grade, and the residual urine volume reduced by more than 100 ml in 15 of 20 patients. For unilateral brain injury, the Fugl-Myer motor assessment (FMA) improved 15.14–26 score in upper extremity compared to 2.35–26 in the control group. The overall reduction in Modified Ashworth score was 0.76–2 compared to 0–1 in the control group. Range of motion (ROM) increased 18.4–80° in elbow, 20.4–110° in wrist and 18.8–130° in forearm, while ROM changed −4.03°−20° in elbow, −2.08°−10° in wrist, −2.26°−20° in forearm in the control group. The improvement of FMA in lower extremity was 9 score compared to the presurgery.

Conclusion:
Nerve transfer generally improves sensorimotor functions in paralyzed limbs and bladder control following CNS injury. The technique effectively creates a ‘bypass’ for signals and facilitates functional recovery by leveraging neural plasticity. It suggested a future of surgery, neurorehabilitation and robotic-assistants converge to improve outcomes for CNS.
Patterns of substance use and initiation timing in adults with substance abuse: a comparison between those with and without attention deficit hyperactivity disorder
Authors: Vaziri-Harami Roya , khademi Mojgan , Zolfaghari Anahita , Vaziri-harami Saharnaz 
Published: June 2024

Background:
Attention deficit hyperactivity disorder (ADHD) is a prevalent psychiatric disorder in childhood and adolescence, persisting into adulthood in 60% of cases, with an adult age prevalence rate of 4%. substance use disorder (SUD) is a recognized comorbidity with significant social and financial implications, necessitating detailed investigation.

Materials and methods:
This longitudinal study focused on adults with SUD in addiction detention in two camps including Toska and Chitgar in the west and south of Tehran during 2021–2022. Participants underwent assessment using the Structured Clinical Interview for DSM Disorders (SCID) to identify individuals with SUD, excluding those with major mental problems. The remaining subjects were assessed by Conner’s questionnaire. And positive cases underwent a comprehensive ADHD interview. The study comprised 50 individuals with ADHD and 90 without ADHD, allowing for a comparative analysis of the onset age of substance use and patterns across both groups. The substances examined included alcohol, cannabis, crack, methamphetamine, tramadol, methadone, opium, ecstasy, morphine, and hypnotics.

Results:
The study revealed a lower age of onset of substance use in the ADHD group. Furthermore, individuals with ADHD exhibited higher rates of alcohol, cannabis, methamphetamine, and tramadol use, while the non-ADHD group showed elevated usage of Ritalin, methadone, ecstasy, morphine, and hypnotics.

Conclusions:
Prompt diagnosis and treatment of ADHD regarding the lower onset age of substance use and a further range of high-risk substances, such as alcohol, methamphetamine, and crack, would be crucial. Additionally, based on these findings, policy recommendations should emphasize early ADHD screening and intervention strategies to mitigate the risk of substance use disorders, thereby addressing the associated social and financial burdens.
Association between switching to integrase strand transfer inhibitors and incident diabetes in people with HIV
Authors: Hwang Y. Joseph , Lesko Catherine R. , Brown Todd T. , Alexander G. Caleb , Zalla Lauren C. , Keruly Jeanne C. , Snow LaQuita N. , Pytell Jarratt D. , Falade-Nwulia Oluwaseun , Jones Joyce L. , Moore Richard D. , Fojo Anthony T. 
Published: June 2024

Objective:Integrase strand transfer inhibitors (INSTI) are associated with weight gain in people with HIV (PWH), but their impact on diabetes is unclear. We evaluated the association between switching from nonnucleoside reverse-transcriptase inhibitors (NNRTI) or protease inhibitors (PI) to INSTI and incident diabetes.Design:Longitudinal cohort study.Methods:We included PWH aged ≥18 years from the Johns Hopkins HIV Clinical Cohort (2007–2023) without history of diabetes who had used NNRTI or PI for ≥180 days. We followed participants up to 10 years from HIV primary care visits where they switched to INSTI or continued NNRTI or PI. We estimated the hazard of incident diabetes associated with switching to INSTI using weighted Cox regression with robust variance estimator.Results:We included 2075 PWH who attended 22 116 visits where they continued NNRTI or PI and 631 visits where they switched to INSTI. Switching to INSTI was associated with a weighted hazard ratio (wHR) of 1.11 [95% confidence interval (CI), 0.77–1.59] for incident diabetes. The association if no weight gain occurred during the first two years was not qualitatively different (wHR 1.22; 95% CI, 0.82–1.80). In a posthoc analysis, switching to INSTI conferred a significant wHR of 1.79 (95% CI, 1.13–2.84) for diabetes within the first two years but not after.Conclusions:Switching from NNRTI or PI to INSTI did not significantly increase overall diabetes incidence in PWH, although there may be elevated risk in the first two years. These findings can inform considerations when switching to INSTI-based regimens.
Poly (ADP-ribose) polymerase-1 regulates HIV-1 replication in human CD4+ T cells
Authors: Martinez Zachary S. , Gutierrez Denisse A. , Valenzuela Carlos , Seong Chang-Soo , Llano Manuel 
Published: June 2024

ABSTRACTThe cellular enzyme poly (ADP-ribose) polymerase-1 (PARP-1) regulates multiple processes that are potentially implicated in HIV-1 infection. However, the role of PARP-1 in HIV-1 infection remains controversial, with reports indicating or excluding that PARP-1 influence early steps of the HIV-1 life cycle. Most of these studies have been conducted with Vesicular Stomatitis virus Glycoprotein G (VSV-G)-pseudotyped, single-round infection HIV-1; limiting our understanding of the role of PARP-1 in HIV-1 replication. Therefore, we evaluated the effect of PARP-1 deficiency or inhibition in HIV-1 replication in human CD4+ T cells. Our data showed that PARP-1 knockout increased viral replication in SUP-T1 cells. Similarly, a PARP-1 inhibitor that targets PARP-1 DNA-binding activity enhanced HIV-1 replication. In contrast, inhibitors affecting the catalytic activity of the enzyme were inactive. In correspondence with the pharmacological studies, mutagenesis analysis indicated that the DNA-binding domain was required for the PARP-1 anti-HIV-1 activity, but the poly-ADP-ribosylation activity was dispensable. Our results also demonstrated that PARP-1 acts at the production phase of the viral life cycle since HIV-1 produced in cells lacking PARP-1 was more infectious than control viruses. The effect of PARP-1 on HIV-1 infectivity required Env, as PARP-1 deficiency or inhibition did not modify the infectivity of Env-deleted, VSV-G-pseudotyped HIV-1. Furthermore, virion-associated Env was more abundant in sucrose cushion-purified virions produced in cells lacking the enzyme. However, PARP-1 did not affect Env expression or processing in the producer cells. In summary, our data indicate that PARP-1 antagonism enhances HIV-1 infectivity and increases levels of virion-associated Env.ImportanceDifferent cellular processes counteract viral replication. A better understanding of these interfering mechanisms will enhance our ability to control viral infections. We have discovered a novel, antagonist effect of the cellular enzyme poly (ADP-ribose) polymerase-1 (PARP-1) in HIV-1 replication. Our data indicate that PARP-1 deficiency or inhibition augment HIV-1 infectivity in human CD4+ T cells, the main HIV-1 target cellin vivo. Analysis of the mechanism of action suggested that PARP-1 antagonism increases in the virus the amounts of the viral protein mediating viral entry to the target cells. These findings identify for the first time PARP-1 as a host factor that regulates HIV-1 infectivity, and could be relevant to better understand HIV-1 transmission and to facilitate vaccine development.
Legal obligation of ESG reporting and the quality of environmental disclosure practices: the case of Moroccan listed industrial companies
Authors: Namoussi Fatima Zahra , Cherqaoui Mariam 
Published: June 2024

Purpose
This paper aims to examine the impact of the legal obligation for environmental, social, and governance (ESG) reporting, introduced in 2019 by the Moroccan Capital Market Authority (AMMC), on the environmental disclosure practices of industrial companies listed on the Casablanca Stock Exchange (CSE).

Design/methodology/approach
An analysis of the content of the ESG reports of the industrial listed companies on the CSE is carried out over the two years that frame the year of implementation of the AMMC circular, i.e. 2018 and 2020, to analyze the difference in the quality of their environmental disclosures using a conformity criterion based on the Environmental section (N°300) of the “Global Reporting Initiative (GRI)” standards.

Findings
The results confirm the presence of a positive effect of the legal obligation for ESG reporting on the quality of environmental reporting of Moroccan industrial listed companies. However, the degree of compliance with the GRI framework remains incomplete.

Originality/value
This study helps to highlight the effectiveness of regulatory measures in improving the disclosure of relevant corporate environmental reporting of listed companies. The study also provides an overview of the progress made in implementing quality environmental reporting standards, specifically the GRI framework, in a developing country, namely, Morocco.
Economic crisis, innovation and organizational responses: evidence from Brazil
Authors: Feitosa Paulo , Garcia Renato 
Published: June 2024

Purpose
The economic crisis of 2008 resulted in a unique context for the empirical experimentation of organizational learning and entrepreneurship theories from Schumpeterian inspiration. The purpose of this paper is to investigate how the economic downturns change the limits and possibilities to pursue both exploration and exploitation and thus achieve innovative performance.

Design/methodology/approach
This study examines an original database with the patent portfolio of 2,309 firms based in Brazil, covering a period of eight years preceding the 2008 economic crisis, that is 2000–2007, and five years thereafter, 2008–2013. To test the hypotheses empirically, the authors use the negative binomial model.

Findings
The findings add to the literature in two ways. First, this study found a positive association between exploitation and exploration behaviour and innovative performance. However, this relation is curvilinear because there are diminishing negative effects on innovation. Second, regarding the distinction between creative destruction and creative accumulation, the results support the prevalence of creative accumulation, although consistent with the notion of co-occurrence of both models.

Originality/value
This study expands the discussion on how entrepreneurs respond to the economic crisis in specific contexts of an emerging economy. We provide new empirical evidence through the exploration of a unique data set on the patent portfolio of 2,309 firms based in Brazil. Most of the previous literature has applied this topic to developed countries, and there are few studies that apply this topic outside the focus of US and European countries.