bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward a predictive theory for environmental enrichment
Authors: Watters Jason V. 
Published: October 2009

AbstractThere have been many applications of and successes with environmental enrichment for captive animals. The theoretical spine upon which much enrichment work hangs largely describes why enrichment should work. Yet, there remains no clear understanding of how enrichment should be applied to achieve the most beneficial results. This lack of understanding may stem in part from the assumptions that underlie the application of enrichment by practitioners. These assumptions are derived from an understanding that giving animals choice and control in their environment stimulates their motivation to perform behaviors that may indicate a heightened state of well‐being. Learning theory provides a means to question the manner in which these constructs are routinely applied, and converting learning theory's findings to optimality predictions suggests a particularly vexing paradox—that motivation to perform appears to be maintained best when acquiring a payoff for expressing the behavior is uncertain. This effect occurs even when the actual value of the payoff is the same for all schedules of certainty of payoff acquisition. The paradox can be resolved by invoking rewards of an alternative type, such as cognitive rewards, or through an understanding of how the average payoff changes with changes in the probability of reward. This model, with measures of the average change of the payoff, suggests testable scenarios by which practitioners can measure the quality of environmental uncertainty in enrichment programs. Zoo Biol 28:609–622, 2009. © 2009 Wiley‐Liss, Inc.
n-3 andn-6 Polyunsaturated fatty acids suppress sterol regulatory element binding protein activity and increase flow of non-esterified cholesterol in HepG2 cells
Authors: Di Nunzio Mattia , van Deursen Diederik , Verhoeven Adrie J. M. , Bordoni Alessandra 
Published: October 2009

The plasma lipid-lowering effect of PUFA, one of their main beneficial effects, is considered to be related to the regulation of lipid biosynthesis through transcription factors including sterol regulatory element binding proteins (SREBP). In the present study, we compared the effect of different PUFA on SREBP activity in HepG2 cells, using a sterol regulatory element–luciferase reporter construct as a probe. Supplementation with different fatty acids reduced SREBP activity in the order 20 : 5n-3 = 18 : 2n-6 = 20 : 4n-6≫18 : 3n-3 = 22 : 6n-3 = 22 : 5n-6≫18 : 1n-9. The suppression of SREBP activity greatly depended on the degree of incorporation of the supplemented PUFA into cellular lipids, and correlated positively with the unsaturation index (r0·831;P < 0·01) of total cell lipids. Supplemented PUFA were also metabolised to longer and more unsaturated species. These processing activities were higher forn-3 thann-6 PUFA (P < 0·01). We studied the effect of PUFA on the intracellular distribution of non-esterified cholesterol, using filipin staining and fluorescence microscopy with or without the cholesterol traffic blocker U18666A. The data show that the incorporation of PUFA increases non-esterified cholesterol flow from the plasma membrane to intracellular membranes. We conclude that suppression of SREBP activity by PUFA depends on the degree of incorporation into cellular lipids, and is associated with increased flow of non-esterified cholesterol between the plasma membrane and intracellular membranes.
Dietary intake of total marine n-3 polyunsaturated fatty acids, eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid and the risk of acute coronary syndrome – a cohort study
Authors: Joensen Albert M. , Schmidt Erik B. , Dethlefsen Claus , Johnsen Søren P. , Tjønneland Anne , Rasmussen Lars H. , Overvad Kim 
Published: October 2009

Dietary intake of marine n-3 PUFA has been negatively associated with the risk of CHD among subjects with known CHD, whereas an effect in healthy subjects is less documented. We assessed the hypothesis that dietary intake of marine n-3 PUFA is negatively associated with the risk of acute coronary syndrome (ACS) in healthy subjects. In the Danish Diet, Cancer and Health cohort study, 57 053 participants were enrolled. Dietary intake of total n-3 PUFA, including EPA, docosapentaenoic acid (DPA) and DHA, was assessed. During a mean follow-up period of 7·6 years, we identified all cases (n 1150) from this cohort with an incident ACS diagnosis in the Danish National Patient Registry or the Cause of Death Registry. Diagnoses were verified through medical record review. In Cox proportional hazard models, we adjusted for established risk factors for CHD. Men in the four highest quintiles of n-3 PUFA intake (>0·39 g n-3 PUFA per d) had a lower incidence of ACS compared with men in the lowest quintile. The hazard ratio was 0·83 (95 % CI 0·67, 1·03) when we compared men in the second lowest and lowest quintile of n-3 PUFA intake. Higher intake of n-3 PUFA did not strengthen this association. Associations for EPA, DPA and DHA were all negative, but less consistent. No convincing associations were found among women. In conclusion, we found borderline significant negative associations between the intake of marine n-3 PUFA and ACS among healthy men.
Congenital stapedial suprastructure fixation with normal footplate mobility: case report
Authors: Lee J H , Jung S H , Kim H C , Park C H , Hong S M 
Published: October 2009

AbstractObjective:We report a case of bilateral conductive hearing loss caused by stapedial suprastructure fixation with normal footplate mobility.Case report:A 50-year-old woman had suffered hearing loss in both ears since childhood. Exploratory tympanotomy revealed immobility of the stapes due to a bony bridge between the stapedial suprastructure and the fallopian canal. The incus was missing, while the malleus handle was minimally deformed. The mobility of the stapes footplate was normal. Post-operatively, the hearing in the right ear improved both subjectively and audiographically, while that in the left ear did not improve because of footplate subluxation during surgery.Conclusion:This is a rare case of congenital stapedial suprastructure fixation with normal footplate mobility. In this patient, development of the second branchial arch was arrested. When performing exploratory tympanotomy for stapedial fixation, one must keep in mind that normal footplate mobility is possible.
Necrobiotic xanthogranuloma of the parotid gland
Authors: Zainal A , Razif M Y , Makhashen M , Swaminathan M , Mazita A 
Published: October 2009

AbstractObjectives:To highlight the first reported case of necrobiotic xanthogranuloma of the parotid gland. We also review the clinical presentations and treatments for this rare condition.Method:Case report and review of necrobiotic xanthogranuloma.Results:A 48-year-old man presented with a right parotid mass. Fine needle aspiration cytology was suggestive of Warthin's tumour, for which the patient underwent a subtotal parotidectomy. The final histopathological diagnosis was necrobiotic xanthogranuloma.Conclusions:Necrobiotic xanthogranuloma may clinically mimic commoner tumours such as Warthin's tumour. Once diagnosed, the clinician should be wary of extracutaneous manifestations and paraproteinaemias. Because of the variability of presentation, there is no consensus on the best treatment for necrobiotic xanthogranuloma, which may include surgery, chemotherapy, interferon, plasmapheresis and radiation therapy.
A social-cognitive model of human behavior offers a more parsimonious account of emotional expressivity
Authors: Zayas Vivian , Tabak Joshua A. , Günaydýn Gül , Robertson Jeanne M. 
Published: October 2009

AbstractAccording to socio-relational theory, men and women encountered different ecologies in their evolutionary past, and, as a result of different ancestral selection pressures, they developed different patterns of emotional expressivity that have persisted across cultures and large human evolutionary time scales. We question these assumptions, and propose that social-cognitive models of individual differences more parsimoniously account for sex differences in emotional expressivity.
Expressed emotions, early caregiver–child interaction, and disorders
Authors: Wiefel Andreas , Schepker Renate 
Published: October 2009

AbstractIn addition to the socio-relational framework of expressive behaviors (SRFB), we recommend integrating theoretical and empirical findings based on attachment theory. We advocate a dynamic interpretation of early caregiver–child interaction. The consequences of models from developmental psychology for the occurrence of psychopathology are demonstrated from a clinical perspective.
Cry baby cry, make your mother buy? Evolution of tears, smiles, and reciprocity potential
Authors: Lyons Minna 
Published: October 2009

AbstractIn this commentary, the idea of reciprocity potential indicators is tied in with ultimate accounts on sex differences in social sensitivity. It is proposed that, rather than crying, smiling is a more likely cooperative signal. The possibility of coevolution and polymorphism in perceptual and signalling systems are also discussed briefly, with a reference to Theory of Mind and Machiavellianism.
The other side of the coin: Intersexual selection and the expression of emotions to signal youth or maturity
Authors: Lozano George A. 
Published: October 2009

AbstractVigil summarizes sex-related differences in emotivity, and presents a psychological model based on the restrictive assumption that responses to stimuli are dichotomous. The model uses for support the concept of intrasexual selection, but ignores intersexual selection. An alternative hypothesis might be that emotivity signals age: maturity in men and youth in women. Integration requires considering all evolutionary biology, not just agreeable concepts.
On the detection of emotional facial expressions: Are girls really better than boys?
Authors: LoBue Vanessa , DeLoache Judy S. 
Published: October 2009

AbstractOne facet of Vigil's socio-relational framework of expressive behaviors (SRFB) suggests that females are more sensitive to facial expressions than are males, and should detect facial expressions more quickly. A re-examination of recent research with children demonstrates that girls do detect various facial expressions more quickly than do boys. Although this provides support for SRFB, further examination of SRFB in children would lend important support this evolutionary-based theory.
Sex differences in emotion expression: Developmental, epigenetic, and cultural factors
Authors: Izard Carroll E. , Finlon Kristy J. , Grossman Stacy R. 
Published: October 2009

AbstractVigil's socio-relational framework of sex differences in emotion-expressive behavior has a number of interesting aspects, especially the principal concepts of reciprocity potential and perceived attractiveness and trustworthiness. These are attractive and potentially heuristic ideas. However, some of his arguments and claims are not well grounded in research on early development. Three- to five-year-old children did not show the sex differences in emotion-expressive behavior discussed in the target article. Our data suggest that Vigil may have underestimated the roles of epigenetic and cultural factors in shaping emotion-expressive behavior.
Biofeedback mechanisms between shapeable endogen structures and contingent social complexes: The nature of determination for developmental paths
Authors: Ferber Sari Goldstein 
Published: October 2009

AbstractBiofeedback mechanisms (a) between individuals, (b) between the individual and the society structures which shape individual cognitions, and (c) within the individual genetic biochemical circulation, may explain the diversity of trustworthiness potential and the option of mutual trust for every individual in any given society.
When organization meets emotions, does the socio-relational framework fail?
Authors: Basso Frédéric , Oullier Olivier 
Published: October 2009

AbstractWe suggest that the framework proposed by Vigil is useful in laboratory contexts but might come up short for in vivo social interactions. Emotions result from cost-benefits trade-offs but are not solely generated at the individual level to establish emotional social spheres. In organizational contexts, emotion expression can be a constitutive part of a professional activity, and observed sex differences might vanish.
The socio-relational framework of expressive behaviors as an integrative psychological paradigm
Authors: Vigil Jacob Miguel 
Published: October 2009

AbstractThis response shows how the socio-relational framework of expressive behaviors may be used to understand and predict social psychological processes, beyond sex differences in the expression of emotion. I use this opportunity to elaborate on several key concepts on the epigenesis of evolved social behaviors that were not fully addressed in the target article. These are: evidence of a natural history of masculine and feminine specialization (sect. R1); phenotypic plasticity and range of reactivity of social behaviors (sect. R2); exploitive and protective functions of social behaviors (sect. R3); and the role of cognition in some affective responses (sect. R4). I conclude by highlighting (in sect. R5) future directions for psychological research from a socio-relational basis.
On the richness and limitations of dimensional models of social perception
Authors: Todorov Alexander 
Published: October 2009

AbstractThe two-dimensional model of social relations outlined in the target article has striking convergence with empirically derived dimensional models of interpersonal perception, inter-group perception, and face evaluation. All these models posit two-dimensional structures related to perceptions of valence/affiliation and power/status. Although these models are parsimonious, they may be insufficient to account for behaviors in specific contexts.
Smiling reflects different emotions in men and women
Authors: Vazire Simine , Naumann Laura P. , Rentfrow Peter J. , Gosling Samuel D. 
Published: October 2009

AbstractWe present evidence that smiling is positively associated with positive affect in women and negatively associated with negative affect in men. In line with Vigil's model, we propose that, in women, smiling signals warmth (trustworthiness cues), which attracts fewer and more intimate relationships, whereas in men, smiling signals confidence and lack of self-doubt (capacity cues), which attracts numerous, less-intimate relationships.
A socio-relational framework of sex differences in the expression of emotion
Authors: Vigil Jacob Miguel 
Published: October 2009

AbstractDespite a staggering body of research demonstrating sex differences in expressed emotion, very few theoretical models (evolutionary or non-evolutionary) offer a critical examination of the adaptive nature of such differences. From the perspective of a socio-relational framework, emotive behaviors evolved to promote the attraction and aversion of different types of relationships by advertising the two most parsimonious properties ofreciprocity potential, or perceived attractiveness as a prospective social partner. These are the individual's (a)perceived capacityor ability to provide expedient resources, or to inflict immediate harm onto others, and their (b)perceived trustworthinessor probability of actually reciprocating altruism (Vigil 2007). Depending on the unique social demands and relational constraints that each sex evolved, individuals should be sensitive to advertise “capacity” and “trustworthiness” cues through selective displays of dominant versus submissive and masculine versus feminine emotive behaviors, respectively. In this article, I introduce the basic theoretical assumptions and hypotheses of the framework, and show how the models provide a solid scaffold with which to begin to interpret common sex differences in the emotional development literature. I conclude by describing how the framework can be used to predict condition-based and situation-based variation in affect and other forms of expressive behaviors.
Cost-effectiveness of Misoprostol in Sweden
Authors: Jönsson Bengt , Haglund Ulf 
Published: October 2009

AbstractBased on an American multicenter study, an economic evaluation of prophylactic misoprostol was undertaken in Sweden. The study included 420 patients with osteoarthritis and nonsteroidal anti-inflammatory drug (NSAID)-associated abdominal pain, but no gastric ulcer at inclusion. The frequency of ulcer development with and without prophylactic misoprostol was assessed at 21.7% and 5.6%, respectively, for a 3-month period. All costs for drugs, ambulatory care, hospital care, loss of production, as well as other factors such as dosage and compliance, were transferred to Swedish conditions. It was concluded that in patients with osteoarthritis and NSAID-induced abdominal pain, prophylaxis with misoprostol is cost-effective in Sweden, which is similar to what is found for other countries. A prerequisite for this result is a frequency of ulcer development of 15%. A patient compliance to prophylactic treatment of more than 60% is also presupposed (79% was observed in the above study). Due to the high age of the osteoarthritis patient population, the cost-effectiveness is influenced to only a minor extent by whether indirect costs are included in the calculation.
Nonexperimental Evaluation of the Effectiveness of a Screening Program for Lung Cancer
Authors: Ebeling K. , Nischan P. 
Published: October 2009

AbstractThe effectiveness of screening to control lung cancer was examined in the German Democratic Republic by analyzing data from a cancer registry and incidence and mortality rates for lung cancer relative to different screening policies, and by two case-control studies. Mortality from lung cancer did not appear to be affected by the screening programs studied. The high cost of mass screening, combined with uncertainty about the benefits of early treatment of lung cancer, outweigh the vague advantages of such screening.
Health Care Technology Transfer in Latin America and the Caribbean
Authors: Coe Gloria A. , Banta David 
Published: October 2009

AbstractThe greatest problem concerning health care technology for developing countries is that they are dependent upon the industrialized world for technology. The only short-term solution to this problem is to improve the choices that are available to them. This goal will require changes in the structure and processes of policy making. A particular difficulty for these countries is the lack of trained personnel in fields related to technology assessment.
The Cleveland Veterans Affairs Medical Center Firm System
Authors: Landefeld C. Seth , Rosenthal Gary E. , Aucott John , Whalen Christopher C. , Wright Jackson T. , Hout Wahoub , Midgette Andre , Ravdin Jonathan I. , Aron David C. 
Published: October 2009

AbstractHospital-based “firms” provide a means for combatting the fragmentation experienced by both patients and caregivers in the modern teaching hospital environment. A “firm” is an academic group practice that includes attending physicians, physician trainees, nurses, other staff, and patients. Each person's relationship with a firm lasts throughout his or her association with a particular institution. This article describes the firm system that was recently implemented on the Medical Service of the Cleveland VAMC. This system incorporates both inpatient and outpatient general medical services and provides for unbiased assignment of patients, physicians, and nurses.
Quality Assessment of Medical Research and Education
Authors: Eriksson Håkan 
Published: October 2009

AbstractDifferent aspects of the process of evaluating research and education are discussed, using the discipline of medicine as a model. The focus is primarily on potential problems in the design of an evaluation. The most important aspects of an assessment are: to create confidence in the evaluation among scientists and/or teachers who are being assessed before beginning; to find experts for whom the scientists and/or teachers have professional respect; to choose assessment methods in relation to the focus, level, and objectives of the evaluation; and to make the report of the evaluation's findings short and explicit.
Economic Evaluation of Hypertension Treatment
Authors: Johannesson Magnus 
Published: October 2009

AbstractA computer simulation model shows that the cost-effectiveness of treating hypertension is highly sensitive to different assumptions about the effectiveness of treatment, the outcome measure, the cost concept, the discounting of effects, and the duration of therapy. Cost-effectiveness analysis should be supplemented by another approach–cost-benefit analysis based on the contingent valuation (CV) method (the measurement, by survey, of willingness to pay). The CV method is tested in two empirical applications that indicate that it is possible to use the method in this area. Its results should be interpreted with caution, however, since the reliability and validity of the method is not yet established.
The Use of Risk-adjusted Complication Rates to Compare Hospitals Performing Coronary Artery Bypass Surgery or Angioplasty
Authors: Hartz Arthur J. , Kuhn Evelyn M. , Green Robert , Rimm Alfred A. 
Published: October 2009

AbstractA hospital's quality of care is generally assessed by a review of individual records. This study used unadjusted and risk-adjusted complication rates to measure the quality of care for hospitals that perform coronary artery bypass surgery or angioplasty. Hospitals differed greatly in their complication rates. Only a small percentage of this difference was due to differences in the risks that patients faced.
The Global Capacity for Manufacturing Vaccines: Prospects for Competition and Collaboration Among Producers in the Next Decade
Authors: Robbins Anthony , Arita Isao 
Published: October 2009

AbstractCan the world respond to the demands of the Children's Vaccine Initiative (CVI) to produce large quantities of affordable vaccines that have never been manufactured previously? Vaccines for the world's birth cohort of 150 million will continue to be produced in the countries that use the greatest part of the global vaccine supply. Thus, the CVI will rely on increased self sufficiency in vaccine production in the developing world and “shared development” of new and improved vaccines. The CVI's goal is to direct product development to meet the needs of immunization programs, but it must not neglect production. Thus, from the start, investment at the front end of the development and production sequence requires attention to the ultimate production capacity.
Adjuvants and Immune Enhancement
Authors: Allison Anthony C. 
Published: October 2009

AbstractAdjuvants increase cell-mediated and humoral immune responses to specific antigens. Used with recombinant viral antigens, they can elicit the production of T lymphocytes that lyse target cells, expressing the antigen in a genetically restricted fashion. Adjuvants can augment the production of interferon-gamma, thereby favoring the production of protective antibody isotopes, such as immuno-globulin G2a in the mouse. Modern adjuvants display the efficacy of Freund's complete adjuvant without its side effects. One such adjuvant is Syntex adjuvant formulation, a synthetic analogue of muramyl dipeptide in a microfluidized squalane/squalene-in-water emulsion. Monophosphoryl lipid A in a similar lipid emulsion is also effective. Immune-stimulating complexes of saponin and antigens elicit potent cell-mediated and humoral responses. A purified saponin component has adjuvant activity with reduced side effects; liposomes also can have adjuvant activity. Administering antigens in adjuvants can overcome low responsiveness in very young and old experimental animals and in those that are genetically low responders. Adjuvants are likely components of a new generation of recombinant and subunit vaccines.