bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biotransformation of butyltin compounds and microbiome diversity in the bottom sediments of the Gulf of Finland, the Baltic Sea
Authors: Кузикова И.Л. , Жаковская З.А. , Медведева Н.Г. 
Published: May 2024

Загрязнение морской среды оловоорганическими соединениями представляет се- рьезную экологическую проблему ввиду их чрезвычайной токсичности для широкого круга орга- низмов. В донных осадках Копорской губы Финского залива выявлен высокий уровень загрязнения соединениями бутилолова. Концентрация трибутилолова и дибутилолова составила 35.7 нг(Sn)/г а.с.о. и 9.7 нг(Sn)/г а.с.о. соответственно. Установлено, что трансформация соединений бутило- лова в донных осадках происходит за счет автохтонной микробиоты осадков. Скорость убыли трибутилолова и дибутилолова составила 0.014 сут-1 и 0.022 сут-1, а периоды их полураспада 49.5 и 31.5 суток соответственно. Метагеномный анализ выявил изменения в таксономическом соста- ве и уменьшение видового разнообразия микробиомов донных осадков в процессе трансфор- мации оловоорганических соединений. В ходе биодеградации соединений бутилолова в донных осадках возрастает численность бактерий родов Acidithiobacillus, Halothiobacillus, Alicyclobacillus, Sulfurospirillum, Denitrovibrio, а также метаногенные археи рода Methanolobus, что может свиде- тельствовать об их потенциальном участии в биодеградации оловоорганических соединений. Полученные результаты могут быть использованы для выявления видов-активных деструкторов трибутилолова с целью разработки научно-обоснованных методов деконтаминации донных осад- ков, загрязненных оловоорганическими соединениями.
Pollution of the marine environment with organotin compounds is a serious environmental problem due to their extreme toxicity to a wide range of organisms. A high level of contamination with butytin compounds was detected in the bottom sediments of the Koporye Bay, the Gulf of Finland, the Baltic Sea. The concentration of tributyltin and dibutyltin reached up to 35.7 ng(Sn)/g DW and 9.7 ng(Sn)/g DW, respectively. The butyltin compounds transformed in bottom sediments due to the activity of autochthonous sediment microbiota. The degradation rate of tributyltin and dibutyltin was 0.014 day-1 and 0.022 day-1, their half-life, 49.5 and 31.5 days, respectively. Metagenomic analysis revealed the changes in taxonomic composition and the decrease in species diversity of the bottom sediment microbiomes during the transformation of organotin compounds. During the biodegradation of butyltin compounds in bottom sediments, the abundance of bacteria of the genera Acidithiobacillus, Halothiobacillus, Alicyclobacillus, Sulfurospirillum, Denitrovibrio, as well as of methanogenic archaea of the genus Methanolobus increases, which may indicate their potential participation in the biodegradation of organotin compounds. These results may be used to identify active tributyltin degraders for developing self-purification methods of bottom sediments contaminated with organotin compounds.
РЕАЛІЗАЦІЯ ПРОГРАМИ РЕЛОКАЦІЇ ПІДПРИЄМСТВ В УКРАЇНІ
Authors: Гапак Наталія , Чубарь Оксана 
Published: May 2024

У статті розглянуто організаційно-економічні та окремі аналітичні аспекти запровадження із початком російсько-української війни Програми релокації бізнесу із зони бойових дій, яка передбачає державну допомогу в підборі площ для розміщення виробництва; перевезенні й розселенні персоналу; доборі працівників у місцях дислокації після переїзду. Зроблено висновок про загалом позитивні результати реалізації Програми як для конкретних підприємств і їх власників, так і для держави в цілому, оскільки це сприяло збереженню виробничих потужностей, робочих місць та економічного потенціалу країни (хоча б частково). У Львівській та Закарпатській областях, куди було релоковано найбільшу кількість підприємств, відбулося поліпшення показників економічної динаміки, зростання кількості робочих місць і податкових надходжень. У загальній кількості релокованих до Закарпатської області суб’єктів господарювання (280 підприємств різних форм власності) найбільшу частку займають підприємства сфери послуг (32,9 %), ІТ індустрії (30,7 %) та переробної промисловості (26,4 %).
На основі систематизації інформації з відкритих публічних джерел зроблено висновок про те, що кожен регіон України у створенні привабливих умов для бізнесу з прифронтових регіонів пропонував специфічні важелі для залучення на свої території. Важливим компонентом втілення в життя Програми стало налагодження комунікацій зацікавлених сторін, консультативне забезпечення з використанням сучасних інформаційних ресурсів.
Реалізація вказаної Програми, як і інших механізмів державної підтримки бізнесу в умовах війни, визнається експертами недостатньо ефективною через бюрократичні складнощі та розтягнутість у часі доступу до відповідних послуг, обмеженість фінансових ресурсів для підтримки і супроводу як безпосередньо процесу переміщення, так і на етапі розміщення і початку господарювання на нових локаціях. Недостатньою є інформаційна та консультаційна підтримка бізнесу на різних етапах.
Coronary calcified nodules versus nonnodular coronary calcifications: a systematic review and meta-analysis
Authors: Oliveri F. , Van Oort M.J.H. , Al Amri I. , Bingen B.O. , Van der Kley F. , Jukema J.W. , Jurado-Roman A. , Montero Cabezas J. 
Published: May 2024

Background
Percutaneous coronary intervention (PCI) on severely calcified coronary lesions is challenging. Coronary calcified nodule (CN) refers to an eccentric and protruding coronary calcification associated with plaque vulnerability and adverse clinical events. This study aims to conduct an extensive review of CNs, focusing on its prognostic impact in comparison with nonnodular coronary calcification (N-CN).

Method
A systematic literature review on PubMed, MEDLINE, and EMBASE databases was conducted for relevant articles. Observational studies or randomized controlled trials comparing CNs and N-CNs were included.

Results
Five studies comparing CNs and N-CNs were pertinent for inclusion. The total number of individuals across these studies was 1456. There were no significant differences in the baseline demographic, clinical, and angiographic data between the CN and N-CN groups. Intracoronary imaging was always utilized. At follow-up, CNs were associated with significantly increased, target vessel revascularization [odds ratio (OR) 2.16; 95% confidence interval (CI): 1.39–3.36, P-value < 0.01, I
2 = 0%] and stent thrombosis (OR 9.29; 95% CI: 1.67–51.79, P-value = 0.01, I
2 = 0%) compared with N-CN. A trend for greater cardiac death was also assessed in the CN group (OR 1.75; 95% CI: 0.98–3.13, P-value = 0.06, I
2 = 0%).

Conclusion
CN has a significantly negative impact on outcomes when compared with N-CN.
Lyophilised protein formulations as a patient-centric dosage form: A contribution toward sustainability paradigm
Authors: Žiberna Maja Bjelošević , Grabnar Pegi Ahlin , Gašperlin Mirjana , Matjaž Mirjam Gosenca 
Published: May 2024

Abstract
At present, society has embraced the fact apropos population aging and climate changes, that demand, amongst others, innovative pharmaceutical technologies, emphasising the development of patient-specific delivery systems and thus the provision of efficient and sustainable drugs. Protein drugs for subcutaneous administration, by allowing less frequent application, represent one of the most important parts of the pharmaceutical field, but their development is inevitably faced with obstacles in providing protein stability and suitable formulation viscosity. To gain further knowledge and fill the gaps in the already constructed data platform for the development of monoclonal antibody formulations, we designed a study that examines small model proteins, i.e., bovine serum albumin. The main aim of the presented work is to evaluate the effect of protein concentrations on critical quality attributes of both, pre-lyophilised liquid formulations, and lyophilised products. Through the study, the hypothesis that increasing protein concentration leads to higher viscosity and higher reconstitution time without affecting the stability of the protein was confirmed. The most important finding is that sucrose plays a key role in the lyophilisation of investigated protein, nevertheless, it can be predicted that, to ensure the beneficial effect of mannitol, its amount has to prevail over the amount of sucrose.
Lipid-based systems with precipitation inhibitors as formulation approach to improve the drug bioavailability and/or lower its dose: a review
Authors: Kovačević Mila , Gašperlin Mirjana , Pobirk Alenka Zvonar 
Published: May 2024

Abstract
Lipid-based systems, such as self-microemulsifying systems (SMEDDS) are attracting strong attention as a formulation approach to improve the bioavailability of poorly water-soluble drugs. By applying the “spring and parachute” strategy in designing supersaturable SMEDDS, it is possible to maintain the drug in the supersaturated state long enough to allow absorption of the complete dose, thus improving the drug’s bio-availability. As such an approach allows the incorporation of larger amounts of the drug in equal or even lower volumes of SMEDDS, it also enables the production of smaller final dosage forms as well as decreased gastrointestinal irritation, being of particular importance when formulating dosage forms for children or the elderly. In this review, the technological approaches used to prolong the drug supersaturation are discussed regarding the type and concentration of polymers used in liquid and solid SMEDDS formulation. The addition of hypromellose derivatives, vinyl polymers, polyethylene glycol, polyoxyethylene, or polymetacrylate copolymers proved to be effective in inhibiting drug precipitation. Regarding the available literature, hypromellose has been the most commonly used polymeric precipitation inhibitor, added in a concentration of 5 % (m/m). However, the inhibiting ability is mainly governed not only by the physicochemical properties of the polymer but also by the API, therefore the choice of optimal precipitation inhibitor is recommended to be evaluated on an individual basis.
Advancing Drone Swarm Simulation: A Comprehensive System for Real-Time Control and Dynamic Interaction
Authors: Herich Dušan , Vaščák Ján 
Published: May 2024

Abstract
The rapid evolution of unmanned aerial vehicles (UAVs), has significantly advanced their capabilities, enabling complex operations that can be enhanced through swarm intelligence. This paper introduces a drone swarm simulator designed to model, analyze, and optimize the cooperative behaviors of drone swarms in diverse operational environments to provide a realistic and scalable platform for the simulation of drones, incorporating real-world physics, communication constraints, and autonomous decision-making algorithms.
Genetic Analysis of Three Geographically Secluded Populations of Nile TilapiaOreochromis niloticus(Cichlidae)
Authors: Popoola Omoniyi Michael 
Published: May 2024

AbstractNile tilapiaOreochromis niloticusis one of the most important fishery resources and a valuable fish species for aquaculture programmes. It is found in almost all waters and is widely dispersed. Several natural populations of this species have been impacted by genetic pollution despite their significant economic relevance. Understanding population structure is a crucial first step in protecting this species in its native habitats as well as in choosing which wild stocks to use in hatchery initiatives. To demonstrate the genetic-population structure of this species, genetic differences among three geographically secluded populations ofO. niloticuswere investigated utilizing mitochondrial DNA cytochrome b gene sequences. The results were used to estimate the levels of genetic variability within and among the populations. The 56 cyt b (821 bp) sequences analysis revealed 21 haplotypes, with a nucleotide diversity of 0.0510 and a haplotype diversity of 0.881. In each of the populations, seven (7) singleton variable sites and 19 informative-parsimony sites, genetic diversity could be identified and few population haplotypes were found, indicating a minor genetic distinction between them. For the purpose of conservation and/or Nile tilapia breeding programmes, this information would assist in choosing the fish populations that maintain greater genetic variation inO. niloticus.
ANALISIS TINDAK TUTUR REPRESENTATIF PADA DAFTAR PUTAR “MKU BAHASA INDONESIA” DALAM CHANNEL RAHMAT PETUGURAN
Authors: Al Farizi Muhammad Akmal , Nurul Azizah Hanifah Rifdah , Putri Silviana Annisa , Linawati Agustin , Utomo Asep Purwo Yudi 
Published: May 2024

Tindak tutur ialah termasuk didalam unsur ataupun komponen pragmatik yang didalamnya dilibatkan terkait pembicara dan juga pendengar. Dalam Tindak tutur terbagi dalam 5 pengelompokan besar antara lain; tindak tutur representatif, komisif, direktif, ekspresif, deklaratif. Dalam artikel penelitian ini hanya membahas salah satu dari jenis tindak tutur yakni tindak tutur representatif. Tindak tutur representatif adalah tindak tutur yang mengikat penutur pada keabsahan tuturan yang diucapkan. Tuturan tersebut membuat penulis tertarik untuk menjadikan bahan kajian karena dalam tindak tutur representatif terdapat banyak kategorinya. Tindak tutur representatif tidak hanya dapat ditemukan pada tuturan langsung saja, akan tetapi dapat juga ditemukan di akun media sosial, seperti media youtube. Oleh karena itu, dalam penelitian ini memiliki tujuan guna mengkaji mengenai tindak tutur representatif pada beberapa video youtube daftar putar dalam channel Rahmat Petuguran, salah satunya dalam video yang berjudul "MKU Bahasa Indonesia". Metode yang peneliti gunakan untuk menyajikan hasil analisis data adalah metode informal, dimana hasil tuturan yang dianalisis tidak menggunakan kata baku secara keseluruhan dan pendekatan dalam penelitian ini berwujud pendekatan pragmatik. Teknik pengumpulan data dalam artikel ini menggunakan teknik simak yang terdiri dari dua teknik yakni teknik simak bebas libat cakap, teknik catat, serta teknik pustaka. Teknik pustaka ialah teknik yang mencakup kegiatan membaca, menyimak, mencatat, dan menganalisis. Hasil pada penelitian ini berupa tindak tutur menyatakan, menunjukkan, menyebutkan, menginformasikan, menuntut, menyarankan, menjelaskan, berspekulasi, dan memberikan contoh. Dengan adanya artikel ini, diharapkan pembaca bisa menemukan makna tindak tutur representatif pada beberapa video youtube dalam channel Rahmat Petuguran yang nantinya bisa dijadikan referensi bagi pembaca.
A Pilot Study of Serum Adenosine Deaminase Levels in Benign and Malignant Breast Lumps at a Tertiary Care Hospital
Authors: Parameswaran Rashmi , Satyanarayana V. , Ashwini R. K. 
Published: May 2024

Objectives:
The primary objective of the study is to measure the serum ADA levels in benign and malignant breast lumps. The secondary objective is to compare the serum ADA levels in benign and Malignant breast lumps, and to assess the use of serum ADA levels as a potential biochemical indicator for the diagnosis of breast carcinoma.

Materials and Methods:
This is a descriptive observational study which is being conducted at Rajarajeswari Medical College and Hospital for 3 months. The patients presenting with breast lumps were subjected to a clinical examination of both breasts and axillae, which were then confirmed by radiological investigations such as mammograms or sonomammograms for a final diagnosis. Blood samples were drawn for the measurement of serum ADA activity, which was measured at 37°C according to the method of Giusti and Galanti, based on the Berthelot reaction. The statistical analysis was done using descriptive and inferential statistics. Yamane’s formula was used to calculate the sample size of 50 patients.

Results:
Out of the 50 cases included in this study, 60% of the patients have malignant breast lumps and 40% of the patients have benign breast lumps. Out of the malignant cases (breast imaging-reporting and data system stage 4 and above), 11.1% are found to have abnormally high serum ADA levels (>24 U/L), while 0% of the benign cases have abnormal serum ADA values (<24 U/L).

Conclusion:
According to the findings in this study, serum ADA values are similar in range for benign and malignant breast lumps. Only 11.1% of the malignant cases show a rise in serum ADA levels, which is not adequate for the diagnosis of breast carcinoma. Hence, contrary to previous studies, serum ADA levels are not a specific indicator for the diagnosis of breast carcinoma. Limitations in this study may include a small sample size and the inclusion of pre-operative cases. A larger sample size may substantiate the result with respect to the use of serum ADA levels as an indicator of breast carcinoma.
NEGOTIATING FEMINIST IDEOLOGY IN ASMA NADIA’S NOVEL ASSALAMUALAIKUM BEIJING (Negosiasi Ideologi Feminis dalam Novel Asma Nadia Assalamualaikum Beijing)
Authors: Rasiah NFN , Bilu La 
Published: May 2024

Feminis dan Islam sering dibenturkan sebagai ideologi yang berlawanan. Islam sebagai agama seringkali dipandang sebagai sumber munculnya praktik-praktik ketidakadilan terhadap perempuan. Akhir-akhir ini, ada upaya untuk menghidupkan kembali nilai-nilai Islam untuk memperkuat posisi perempuan, terutama bagi mereka yang lahir dan hidup dalam konteks budaya berbasis Islam. Artikel ini bertujuan untuk mengungkap upaya negosiasi ideologi feminis dalam novel Assalamualaikum Beijing karya Asma Nadia. Feminisme multikultural digunakan sebagai perspektif dalam mengkaji isu ideologi feminis dalam novel dengan asumsi bahwa perempuan tidak diciptakan dan dikonstruksi dengan cara yang sama tetapi bergantung pada latar belakang sosial budayanya. Hasil penelitian menunjukkan bahwa novel ini menekankan kemandirian perempuan dengan mendorong mereka melalui pendidikan dan karir untuk melepaskan diri dari masalah ekonomi dan sosial. Namun, kemandirian dan kesetaraan perempuan juga harus didukung oleh nilai-nilai agama (Islam). Tampaknya novel ini melawan stereotip yang menganggap atribut agama (Islam) yang melekat pada perempuan sebagai kurungan atau bentuk subordinasi, seperti hijab dan taaruf, namun atribut tersebut justru menjadi bentuk pembebasan dan otonomi perempuan. Feminism and Islam are often viewed as opposing ideologies. Islam as a religion is seen by feminists as the source of the emergence of fraudulent practices against women. However, in the present decade, feminists have developed their ideas dealing with cultural attributes, particularly about Islamic rule on women. There has been an effort to enliven Islamic values to strengthen the position of women, especially for those who were born and live in an Islamic-based culture. This article aims to reveal the negotiation of feminist ideology in Assalamualaikum Beijing novel written by Asma Nadia. Multicultural feminism is used as a perspective in examining how feminist ideology is negotiated in the novel. The assumption that women are not created and constructed in the same social and cultural circumstances, thereby having a different way to exist in society. The results show that the novel emphasizes women's independence by encouraging women's education and career to liberate themselves from economic and social shortcomings. However, women's independence and equality must also be in line with religious (Islamic) values. It seems that the novel fights against the stereotypes of Islamic attributes attached to women as confinement or a form of subordination, such as hijab and taaruf, these attributes, on the other hand, become a form of women's self-liberation and autonomy.
Gigantismo en Ecuador: análisis del primer reporte publicado en 1841
Authors: Valarezo Sevilla Diego , Sarzosa Terán Vanessa , Pinto C. Miguel 
Published: May 2024

El gigantismo es una enfermedad rara que se caracteriza por una producción excesiva de hormona del crecimiento (GH) cuando las epífisis aún no se cierran, y tiene una incidencia anual de 8 a 11 casos por millón de habitantes. La mayoría de los casos se deben a un adenoma de la hipófisis, puede ocurrir de forma esporádica o por un factor hereditario, habiéndose encontrado una causa genética en un poco menos del 50% de los casos. El principal síntoma de la enfermedad es un crecimiento anormalmente incrementado, que afecta al sistema músculo-esquelético, y se acompaña de otras morbilidades concomitantes. Analizamos una publicación de 1841 del Dr. Abel Victorino Brandin, en la que describe el caso de una paciente indígena con gigantismo, habitante de una comunidad de Cayambe – Ecuador. La descripción original del caso es de buena calidad, a pesar del uso de algunos términos que en la actualidad no son políticamente correctos, sintetizando las características de una mujer con hipercrecimiento armónico. Esta contribución busca promover el rescate y reanálisis de casos icónicos de la literatura médica ecuatoriana, para mejorar el entendimiento de la historia de la medicina del país, y en este caso específico en el contexto actual del conocimiento sobre el gigantismo.
The Empowering Human Resources Academically Based On Bilingual Environment At Pesantren Al Multazam and Darut Taqwa Mojokerto by Using Asset-Based Community Development (ABCD) Approach
Authors: Prastyo Hari , Rinda Rinda , Wahyudi Imam 
Published: May 2024

This article describes a community outreach program that aims to teach human rights in an impartial manner inside a multilingual environment at Mojokerto, that are Pesantren Al Mulatzam and Darut Taqwa. This project used conceptualisation of Aset-Based Community Development (ABCD) to develop aset as language tutors, bilingual communities, and Pesantren environs. The main cognitive content is to improve the curriculum and bilingual text books while analyzing the goals, restraint, and project strategy. This article also summarizes previous research on the project of fundamental quantity national participation.
The topics included the role of human resources management, the theatrical role of heutagogy in primary education, bilingual education, and speech communication in primary schools. Moreover, the project has been presented at Pesantren Al Mulatzam and Darut Taqwa of Mojokerto for research on Human Education with a Multilingual Environment.
Mosquito Species Diversity and Abundance Patterns in Plots with Contrasting Land Use and Land Cover in Bloomington, Indiana
Authors: Khan Sajjad , Simons Aidan , Campbell Lauren M. , Claar Natalie A. , Abel Madison G. , Chaves Luis F. 
Published: May 2024

ABSTRACT
Land use and land cover (LULC) gradients are associated with differences in mosquito species composition and the entomological risk of mosquito-borne disease. Here, we present results from a season-long study of mosquito species richness and abundance with samples collected at 9 locations from 2 plots with contrasting LULC, an urban farm and a forest preserve, in Bloomington, IN, a city in the midwestern USA. With a total sampling effort of 234 trap-nights, we collected 703 mosquitoes from 9 genera and 21 species. On the farm, we collected 15 species (285 mosquitoes). In the preserve, we collected 19 species (418 mosquitoes). Thirteen species were common in both study plots, 2 were exclusive to the farm, and 6 were exclusive to the forest preserve. In both plots, we collected Aedes albopictus and Ae. japonicus. In the farm, the most common mosquito species were Culex restuans/Cx. pipiens and Coquillettidia perturbans. In the preserve, Ae. japonicus and Ae. triseriatus were the 2 most common mosquito species. Time series analysis suggests that weather factors differentially affected mosquito species richness and mosquito abundance in the plots. Temperature, relative humidity (RH), and precipitation were positively associated with richness and abundance at the farm, while increases in the SD of RH decreased both richness and abundance at the preserve. Our results highlight the importance that LULC has for mosquito species diversity and abundance and confirm the presence of Ae. albopictus and Ae. japonicus in southwestern Indiana.