bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tornado‐induced vibration assessment of construction elevator attached to high‐rise buildings
Authors: He Zheng , Gao Maoxing , Liang Tian , Lai Xiao , Lu Yi , Pan Feng 
Published: May 2024

SummaryAs one of major construction facilities, the safety concern about elevator outer‐attached to slender high‐rise buildings during construction needs to be seriously addressed. To specifically identify the risk of such slender building–elevator systems in extreme tornado wind field, a safety assessment strategy using the critical velocity envelope is systematically developed. To overcome the difficulties in modeling such building–elevator system, a modified generalized flexural‐shear model developed previously was employed to reach an efficient estimate on the response of a case high‐rise building under simulated tornado wind excitations. To account for the effect of the flexibility of high‐rise building on the response of its attached construction elevator, the response of the elevator was obtained by finite element analysis with applied wind forces, as well as the displacement excitations at its supports with the building. To simulate the typical failure modes of elevator in all states, some critical reference velocity‐based envelopes were generated for the safety assessment where the factors of wind velocity, wind direction, and cage level are systematically addressed. The safety envelopes of the building–elevator system were proved to be instinctively efficient for the assessment of its wind resistance under various scenarios.
Unveiling the potential of Satureja calamintha nepeta: A study on its phytochemical composition and antibacterial activity
Authors: Hayani Mouhcine , Benabbouha Tariq , Nachit Wafaa , Byadi Said , Chefira Khalil , Aboulmouhajir Aziz , Tounsi Abdessamad , Zair Touriya 
Published: May 2024

AbstractSatureja calamintha nepeta is a plant native to northwestern Morocco. The purpose of this investigation is to identify the chemical composition and evaluate the antibacterial of the essential oil extracted from this plant. Firstly, a quality inspection of the plant was carried out to quantify its level of metals, especially the heavier ones, using the ICP technique. Gas chromatography/mass spectrometry was used to characterize the chemical composition of essential oil. The chromatogram analysis shows the presence of 27 compounds, that is, 99.2% of the essential oil, with 1,8‐cineole (34.34%) and cis‐pinocamphone (11.87%) being the most significant. The antibacterial effectiveness of the essential oil was tested using the disc diffusion method against 6 gram‐positive and gram‐negative pathogens. The essential oil shows strong activity against Escherichia coli and Escherichia vekanda strains, with an MIC value of about 2.80 µg/mL. The authors were benefited from the modeling technique to better understand the antibacterial activity.
Evaluation of vat blue removal by Aspergillus niger using scanning electron microscopy and glucose oxidase enzyme activity
Authors: Lira Pérez Juana , Figueroa Estrada Juan Carlos , García Rivero Mayola , Rodríguez Vázquez Refugio 
Published: May 2024

AbstractThe use of fungi to reduce dye removal in water from diverse industries can be an efficient option for solving environmental problems. However, the mycoremediation processes involved in color removal are unknown. In this article, Aspergillus niger CDBB‐H‐175 was applied for vat blue discoloration (DC). Hence, inactive biomass by two methods (metabolic inhibitor and heat) and active biomass were studied by scanning electron microscopy and enzyme activities to determine the vat blue DC. When using active biomass, 62% of DC, glucose oxidase (GOX) enzyme activity, 1.19 U/mL and 1.43 mg/L of H2O2 were obtained. It was observed that 68% of DC was due to the degradation process and 32% was due to biomass sorption. When the biomass was inactivated with sodium azide, DC increased by 90% (1.45‐fold), low GOX activity (0.138 U/mL), and H2O2 (0.25 mg/L) were detected. High DC might be due to a high dye sorption in hyphae, since an increase in the thickness and morphology of the hyphae were observed by SEM. Inactivated biomass through heating, showed a 69.5% of DC, where 0.01 U/mL GOX and 0.25 mg/L H2O2 were reached, demonstrating that inactivation of A. niger biomass by sodium azide can be considered as an alternative treatment for colored wastewater.
Vulvar oedema secondary to exogenous oestrogen exposure in a paediatric canine patient
Authors: May Natasha , McLean Louise , Pitorri Francesca , Baptista Lara 
Published: May 2024

AbstractA 12‐week‐old, female, entire miniature dachshund presented with a 3‐week history of progressive vulval enlargement with an associated clear serous sanguinolent discharge. Vulval oedema was noted on clinical exam. Further investigations included a complete cell count, computer tomography and a guarded vaginal swab, which revealed vaginal epithelial cell keratinisation. After thorough anamnesis, the clinical signs were concluded to be a result of exogenous oestrogen exposure.
Writing an abstract
Authors: Herbst Elmar , Kopf Sebastian ,   the AGA Research Committee
Published: May 2024

AbstractAbstracts are the most important part of a manuscript as they are the most widely read. In general, unstructured abstracts must be differentiated from structured abstracts. While the latter follow a clear and obvious structure (e.g., background, aim, methods, results, conclusion), unstructured abstracts are basically written the same way but without this obvious structure. Abstracts are generally written in past tense and the third person, and must follow the instructions provided by each journal or conference. Importantly, the key message of the abstract should align to the main manuscript and should not contain any other or irrelevant information. In this manuscript, for each section of an abstract, tips and tricks are provided for preparing an abstract.
Cyanobacterial Biocrust on Biomineralized Soil Mitigates Freeze–Thaw Effects and Preserves Structure and Ecological Functions
Authors: Kimura Keiichi , Okuro Toshiya 
Published: May 2024

AbstractBiocrust inoculation and microbially induced carbonate precipitation (MICP) are tools used in restoring degraded arid lands. It remains unclear whether the ecological functions of the two tools persist when these methods are combined and subjected to freeze–thaw (FT) cycles. We hypothesized a synergetic interaction between MICP treatment and biocrust under FT cycles, which would allow both components to retain their ecological functions. We grew cyanobacterial (Nostoc commune) biocrusts on bare soil and on MICP (Sporosarcina pasteurii)-treated soil, subjecting them to repeated FT cycles simulating the Mongolian climate. Generalized linear modeling revealed that FT cycling did not affect physical structure or related functions but could increase the productivity and reduce the nutrient condition of the crust. The results confirm the high tolerance of MICP-treated soil and biocrust to FT cycling. MICP treatment + biocrust maintained higher total carbohydrate content under FT stress. Our study indicates that biocrust on biomineralized soil has a robust enough structure to endure FT cycling during spring and autumn and to promote restoration of degraded lands.
Heterologous expression and structure prediction of a xylanase identified from a compost metagenomic library
Authors: Sousa Joana , Santos-Pereira Cátia , Gomes Joana S. , Costa Ângela M. A. , Santos Andréia O. , Franco-Duarte Ricardo , Linhares João M. M. , Sousa Sérgio F. , Silvério Sara C. , Rodrigues Lígia R. 
Published: May 2024

Abstract
Xylanases are key biocatalysts in the degradation of the β‐1,4‐glycosidic linkages in the xylan backbone of hemicellulose. These enzymes are potentially applied in a wide range of bioprocessing industries under harsh conditions. Metagenomics has emerged as powerful tools for the bioprospection and discovery of interesting bioactive molecules from extreme ecosystems with unique features, such as high temperatures. In this study, an innovative combination of function-driven screening of a compost metagenomic library and automatic extraction of halo areas with in-house MATLAB functions resulted in the identification of a promising clone with xylanase activity (LP4). The LP4 clone proved to be an effective xylanase producer under submerged fermentation conditions. Sequence and phylogenetic analyses revealed that the xylanase, Xyl4, corresponded to an endo-1,4-β-xylanase belonging to glycosyl hydrolase family 10 (GH10). When xyl4 was expressed in Escherichia coli BL21(DE3), the enzyme activity increased about 2-fold compared to the LP4 clone. To get insight on the interaction of the enzyme with the substrate and establish possible strategies to improve its activity, the structure of Xyl4 was predicted, refined, and docked with xylohexaose. Our data unveiled, for the first time, the relevance of the amino acids Glu133 and Glu238 for catalysis, and a close inspection of the catalytic site suggested that the replacement of Phe316 by a bulkier Trp may improve Xyl4 activity. Our current findings contribute to enhancing the catalytic performance of Xyl4 towards industrial applications.

Key points
• A GH10 endo-1,4-β-xylanase (Xyl4) was isolated from a compost metagenomic library
• MATLAB’s in-house functions were developed to identify the xylanase-producing clones
• Computational analysis showed that Glu133 and Glu238 are crucial residues for catalysis

Graphical abstract
Deep learning-driven automated quality assessment of ultra-widefield optical coherence tomography angiography images for diabetic retinopathy
Authors: Jin Yixiao , Gui Fu , Chen Minghao , Chen Xiang , Li Haoxuan , Zhang Jingfa 
Published: May 2024

Abstract
Image quality assessment (IQA) of fundus images constitutes a foundational step in automated disease analysis. This process is pivotal in supporting the automation of screening, diagnosis, follow-up, and related academic research for diabetic retinopathy (DR). This study introduced a deep learning-based approach for IQA of ultra-widefield optical coherence tomography angiography (UW-OCTA) images of patients with DR. Given the novelty of ultra-widefield technology, its limited prevalence, the high costs associated with equipment and operational training, and concerns regarding ethics and patient privacy, UW-OCTA datasets are notably scarce. To address this, we initially pre-train a vision transformer (ViT) model on a dataset comprising 6 mm × 6 mm OCTA images, enabling the model to acquire a fundamental understanding of OCTA image characteristics and quality indicators. Subsequent fine-tuning on 12 mm × 12 mm UW-OCTA images aims to enhance accuracy in quality assessment. This transfer learning strategy leverages the generic features learned during pre-training and adjusts the model to evaluate UW-OCTA image quality effectively. Experimental results demonstrate that our proposed method achieves superior performance compared to ResNet18, ResNet34, and ResNet50, with an AUC of 0.9026 and a Kappa value of 0.7310. Additionally, ablation studies, including the omission of pre-training on 6 mm × 6 mm OCTA images and the substitution of the backbone network with the ViT base version, resulted in varying degrees of decline in AUC and Kappa values, confirming the efficacy of each module within our methodology.
Light competition drives species replacement during secondary tropical forest succession
Authors: Matsuo Tomonari , Martínez-Ramos Miguel , Onoda Yusuke , Bongers Frans , Lohbeck Madelon , Poorter Lourens 
Published: May 2024

AbstractLight competition is thought to drive successional shifts in species dominance in closed vegetations, but few studies have assessed this for species-rich and vertically structured tropical forests. We analyzed how light competition drives species replacement during succession, and how cross-species variation in light competition strategies is determined by underlying species traits. To do so, we used chronosequence approach in which we compared 14 Mexican tropical secondary rainforest stands that differ in age (8–32 year-old). For each tree, height and stem diameter were monitored for 2 years to calculate relative biomass growth rate (RGR, the aboveground biomass gain per unit aboveground tree biomass per year). For each stand, 3D light profiles were measured to estimate individuals’ light interception to calculate light interception efficiency (LIE, intercepted light per unit biomass per year) and light use efficiency (LUE, biomass growth per intercepted light). Throughout succession, species with higher RGR attained higher changes in species dominance and thus increased their dominance over time. Both light competition strategies (LIE and LUE) increased RGR. In early succession, a high LIE and its associated traits (large crown leaf mass and low wood density) are more important for RGR. During succession, forest structure builds up, leading to lower understory light levels. In later succession, a high LUE and its associated traits (high wood density and leaf mass per area) become more important for RGR. Therefore, successional changes in relative importance of light competition strategies drive shifts in species dominance during tropical rainforest succession.
Iterative method for large-scale Timoshenko beam models assessed on commercial-grade paperboard
Authors: Görtz Morgan , Kettil Gustav , Målqvist Axel , Fredlund Mats , Edelvik Fredrik 
Published: May 2024

AbstractLarge-scale structural simulations based on micro-mechanical models of paper products require extensive numerical resources and time. In such models, the fibrous material is often represented by connected beams. Whereas previous micro-mechanical simulations have been restricted to smaller sample problems, large-scale micro-mechanical models are considered here. These large-scale simulations are possible on a non-specialized desktop computer with 128GB of RAM using an iterative method developed for network models and based on domain decomposition. Moreover, this method is parallelizable and is also well-suited for computational clusters. In this work, the proposed memory-efficient iterative method is numerically validated for linear systems resulting from large networks of Timoshenko beams. Tensile stiffness and out-of-plane bending stiffness are simulated and validated for various commercial-grade three-ply paperboards consisting of layers composed of two different types of paper fibers. The results of these simulations show that a linear network model produces results consistent with theory and published experimental data
Sorgebeziehungen in der Betreuung pflegebedürftiger Menschen durch migrantische Live-Ins: Ein Blick durch die Brille der Care-Ethik
Authors: Seidlein Anna-Henrikje , Kuhn Eva , Kohlen Helen 
Published: May 2024

ZusammenfassungMigrantische Pflege- und Betreuungskräfte, die zusammen mit pflegebedürftigen Menschen in ihren Haushalten leben (sog. migrantische Live-Ins), sind eine tragende Säule der ambulanten Langzeitpflege in zahlreichen Ländern – so auch in Deutschland. Zur Arbeits- und Lebenssituation der Live-Ins liegen inzwischen zahlreiche empirische Untersuchungen vor, die damit einhergehende Problemlagen offenbaren. Ein Schlüsselelement der Live-In Arrangements, nämlich die Beziehungen zwischen den Involvierten, wurde bislang jedoch aus ethischer Perspektive noch nicht systematisch untersucht.Aufbauend auf sozio-empirischen Arbeiten, die die Bedeutung von „Care-Networks“ dargelegt haben, gehen wir von der Annahme aus, dass Live-Ins auf verschiedenen Ebenen in ein Netz von Beziehungen eingebettet sind, die für ihre Arbeits- und Lebenssituation wesentlich sind. Mit Hilfe der vier Care-Phasen Joan Trontos werden in diesem Beitrag bestehende Abhängigkeiten beschrieben und anhand der korrespondierenden vier ethischen Dimensionen reflektiert. Zentral sind die Fragen, wie sich die Abhängigkeiten im Live-In Arrangement auf der Basis des bisherigen Korpus empirischer Studien charakterisieren lassen und wie die Beziehungsstrukturen mit Fokus auf die Elemente Macht, Abhängigkeit und Vertrauen in der Care-ethischen Reflexion eingeordnet werden können.Auf der Basis dieser Analyse zeigt sich, dass die aus der Gleichzeitigkeit verschiedener Formen von Asymmetrie und gegenseitiger Abhängigkeit resultierende Ambivalenz in Live-In Arrangements allgegenwärtig ist und scheinbar widersprüchliche Beziehungsformen und Emotionen entstehen lässt. Die Verantwortlichkeiten der Beteiligten füreinander sind vage und werden auf der Grundlage impliziter Annahmen und problematischer Rollenerwartungen ständig neu ausgehandelt und auch ohne Aushandlung zugewiesen.Es gilt künftig, nicht nur auf der Mikroebene des einzelnen häuslichen Pflegearrangements Verantwortlichkeiten aus den unterschiedlichen Positionen und Rollen heraus und mit Blick auf die changierenden Prozesse der Sorgebeziehungen besser zu verstehen und zu klären, sondern sich ebenfalls auf der Meso- und Makroebene – bereichert durch Care-ethische Perspektiven – den drängenden ethischen Fragen und Problemen in Live-In Arrangements zu stellen.
Magma recharge in persistently active basaltic–andesite systems and its geohazards implications: the case of Villarrica volcano, Chile
Authors: Cortés J. A. , Gertisser R. , Calder E. S. 
Published: May 2024

AbstractWe report whole-rock chemistry, mineral chemistry, and volatile content from Villarrica volcano’s major recent paroxysms and background activity. Composition of the volcanic products are basalt to basaltic andesite with whole-rock SiO2 content between 50 and 56 wt%, and a mineralogy dominated by olivine (Fo71-80), clinopyroxene (Mg# ~ 50) and plagioclase (An60–80). Volatile contents in melt inclusions are up to 1.5 wt% H2O, 500 ppm CO2, 1230 ppm sulfur and 580 ppm chlorine. Regardless of the type of activity, there are no substantial variations in whole-rock composition or the volatile content when the activity switches from background activity to a major paroxysm, strongly suggesting that this shift does not just depend on the arrival of new magma in the shallow magmatic system. Geothermobarometry constrains crystallization of the major mineral phases at various depths between 3 and 12.7 km, suggesting that degassing of a volatile-rich recharge magma occurs deeper than 12 km, producing efficient mixing throughout the whole system, and sustaining the lava lake activity in Villarrica’s summit crater. The occurrence of a permanent lava lake also suggests that the magma recharge must be close to continuous and therefore sudden changes between background and paroxysmal volcanic activity are likely controlled by relatively small changes in the rate of recharge and/or the volatile release rate in the magmatic system. This has important implications for the understanding of eruption triggers and the forecasting of volcanic eruptions.
Graphical abstract
Coralline Algal Population Explosion in an Overgrazed Seagrass Meadow: Conditional Outcomes of Intraspecific and Interspecific Interactions
Authors: Martínez López Isis Gabriela , Leemans Luuk , van Katwijk Marieke M. , Ávila-Mosqueda S. Valery , van Tussenbroek Brigitta I. 
Published: May 2024

AbstractInteractions such as mutualism and facilitation are common in ecosystems established by foundation species; however, their outcomes vary and show conditionality. In a Mexican Caribbean Bay, a seagrass-coralline algae (rhodoliths) mutualism protects the seagrass Thalassia testudinum from green turtle overgrazing. We postulate that the state of the seagrass meadow in this bay depends on the strengths of the interactions among seagrasses, green turtles, and coralline algae. Spatio-temporal changes through satellite imagery showed rhodolith bed developed rapidly from 2009 (undetected) to 2016 (bed of 6934 m2). Typically, such rapid expansion of the rhodoliths does not occur in seagrass meadows. An in situ growth experiment of coralline algae showed that a combination of reduction in light and wave movement (usual in dense seagrass meadows) significantly reduced their growth rates. In the rhodolith beds, the growth rates of the coralline algae Neogoniolithon sp. and Amphiroa sp. were high at 9.5 mm and 15.5 mm per growth tip y−1, respectively. In a second experiment, we found lower mortality in coralline algae within a rhodolith bed compared to algae placed outside the bed, likely explained by the reduced resuspension that we found in a third experiment, and this positive feedback may explain the high population increase in the rhodoliths, once established when the turtles grazed down the seagrass canopy. Therefore, the grazing-protection mutualism between seagrasses and coralline algae is thus conditional and came into existence under a co-occurrence of intensive grazing pressure and rapid population growth of coralline algae facilitated by positive feedback from increased growth and reduced sediment resuspension by the dense rhodolith bed.
Safety of Janus kinase inhibitors compared to biological DMARDs in patients with rheumatoid arthritis and renal impairment: the ANSWER cohort study
Authors: Nakayama Yoichi , Onishi Akira , Yamamoto Wataru , Yoshikawa Ayaka , Shiba Hideyuki , Yoshida Naofumi , Son Yonsu , Shirasugi Iku , Maeda Toshihisa , Katsushima Masao , Hashimoto Motomu , Etani Yuki , Itami Tetsu , Nozaki Yuji , Onizawa Hideo , Fujii Takayuki , Murakami Kosaku , Murata Koichi , Tanaka Masao , Matsuda Shuichi , Morinobu Akio 
Published: May 2024

AbstractData on the safety of Janus kinase inhibitors (JAKis) in patients with renal impairment are lacking. This study aimed to investigate the safety of JAKis compared to biological (b) DMARDs in patients with rheumatoid arthritis (RA) and renal impairment. We used a multi-centre observational registry of patients with RA in Japan (the ANSWER cohort). We assessed the drug retention rates of b/targeted synthetic DMARDs with different modes of action (tumour necrosis factor inhibitors (TNFis), immunoglobulins fused with cytotoxic T-lymphocyte antigen (CTLA-4-Ig), interleukin-6 receptor inhibitors (IL-6Ris), and JAKis) in patients with RA stratified by pre-treatment estimated glomerular filtration rate (eGFR) levels. The time to discontinuation of bDMARDs or JAKis was analysed using a multivariate Cox proportional hazards model This study included 3775 patients, who were classified into three groups (the normal group (eGFR ≥ 60 mL/min/1.73 m2): 2893 patients; CKDa group (eGFR 45–60 mL/min/1.73 m2): 551; and CKDb group (eGFR < 45 mL/min/1.73 m2): 331). In the CKDb group, the 12-month drug retention rate due to adverse events (AE) was the lowest in patients treated with JAKi (TNFi: 93.1%; IL-6Ri: 94.1%; CTLA-4-Ig: 92.3%; JAKi: 75.1%). In the normal and CKDa groups, drug retention rates due to AE were similar among patients treated with bDMARDs and JAKi. In contrast, drug retention rates due to inefficacy were similar between bDMARDs and JAKis in all groups. In the Cox-proportional model, in the CKDb group, TNFi, IL-6Ri, and CTLA-4-Ig showed lower incidence of drug discontinuation due to AE than JAKis (TNFi: hazard ratio = 0.23 (95% confidence interval 0.09–0.61), IL-6Ri: 0.34 (0.14–0.81), CTLA-4-Ig: 0.36 (0.15–0.89)). JAKis showed the lowest drug retention due to AE in patients with moderate-to-severe and severe renal impairment (eGFR < 45 mL/min/1.73 m2). Physicians should pay more attention to renal function when using JAKis than when using bDMARDs.