bluuebunny/crossref_metadata_2025_split huggingface dataset:
Degradation kinetics of azo dye reactive Red SBE wastewater by complex ultraviolet and hydrogen peroxide process
Authors: Xu Hang , Xu Wenguo , Wang Jinfu 
Published: July 2010

AbstractUV/H2O2 was applied to deal with azo dye Reactive Red SBE (RR SBE) in aqueous and effects of hydrogen peroxide dosage, initial dye dosage, pH value, and different anions on color removal were investigated in detail. The online spectrophotometric method was used to detect the change dye absorbance at different reaction time. The results show that RR SBE can be completely decomposed in less than 40 min with 4.412 mM H2O2 dosage, initial dye 17 mg L−1 and neutral ambient. The RR SBE degradation performance follows pseudo first order kinetics and the reaction rate constant of ·OH and RR SBE is 2.32 × 109 M−1 s−1 that is estimated by UV/H2O2 kinetic model. The anions inhibiting effect on dye decolorization follows the order of PO43− > CO32− > Cl− > SO42− > HCO3− > HPO42−. The main intermediate product is phthalic acid dimethyl ester after UV/H2O2 degradation and possible decomposition mechanism of RR SBE is predicted by GC‐MS analysis. © 2010 American Institute of Chemical Engineers Environ Prog, 2011
Acute toxicity of fungicide formulations to amphibians at environmentally relevant concentrations
Authors: Jason Belden , McMurry Scott , Smith Loren , Reilley Paris 
Published: July 2010

Abstract
Fungicide use on row crops is increasing dramatically due to promotion of these products for general plant health and increased yield even during low disease pressure. These fungicides are applied aerially, which may lead to amphibian exposure within fields or in nearby habitat. Exposure to three of these fungicides at environmentally relevant conditions resulted in mortality for Bufo tadpoles and juveniles for two of the fungicides. Headline®, the most commonly used on row crops, resulted in &gt;50% mortality for juveniles at corn label application rates and 100% mortality for tadpoles at one-tenth the label rate for corn. Stratego® killed 40% of exposed tadpoles on average at the corn label rate, but only 7% of the juveniles. Overall, Quilt® appeared less toxic than the other fungicides, resulting in 7 to 10% mortality of tadpoles and 4 to 22% mortality of juveniles at all concentrations (from 0.1× to 10× label rate). These fungicides, especially Headline, may pose a major hazard for amphibians exposed as tadpoles and/or juveniles at environmentally relevant concentrations. Environ. Toxicol. Chem. 2010;29:2477–2480. © 2010 SETAC
A multi‐objective optimization approach for assessment of technical, commercial and environmental performance of microgrids
Authors: Schwaegerl Christine , Tao Liang , Mancarella Pierluigi , Strbac Goran 
Published: July 2010

AbstractThis paper proposes a multi‐objective optimization model to evaluate potential economic, technical and environmental benefits of Microgrid operation. Internalization of external costs such as induced by energy losses (network related) and CO2 emissions (environmentally related) is performed to address the interests of different agents within a single optimization framework. After presenting four reference operation strategies, a multi‐layered scheduling algorithm based on genetic algorithm and linear/quadratic programming is introduced in detail. The algorithm is applied to a UK urban test grid with four different levels of penetration of distributed energy resources. The simulation results lead to the recommendation of a combined dispatch strategy that can simultaneously satisfy all constraints and provide a proper compromise for conflicting objectives of different stakeholders involved in energy supply chain. In particular, a Pareto front representation of the optimization results is also given to further illustrate the multi‐objective nature of the problem. Copyright © 2010 John Wiley & Sons, Ltd.
Sonnige Aussichten mit organischen Solarzellen
Authors: Riede Moritz , Polte Annette , Leo Karl 
Published: July 2010

AbstractBei der Umwandlung des Sonnenlichts in elektrische Energie spielen Solarzellen eine Schlüsselrolle. Dabei bieten neuartige Konzepte auf der Grundlage organischer Halbleiter viele Vorteile gegenüber ihren anorganischen Verwandten auf Siliziumbasis, die auf Dächern und in Taschenrechnern verbreitet sind. Noch aber ist ihr Wirkungsgrad zu niedrig für den großflächigen Einsatz. Ein bundesweites Forschungsprogramm will dies ändern.
Chromosomal abnormalities in transformed Ph‐negative myeloproliferative neoplasms are associated to the transformation subtype and independent of JAK2 and the TET2 mutations
Authors: Nguyen‐Khac Florence , Lesty Claude , Eclache Virginie , Couronné Lucile , Kosmider Olivier , Andrieux Joris , Collonge‐Rame Marie‐Agnes , Penther Dominique , Lafage Marina , Bilhou‐Nabera Chrystele , Chapiro Elise , Mozziconacci Marie‐Joelle , Mugneret Francine , Gachard Nathalie , Nadal Nathalie , Lippert Eric , Struski Stephanie , Dastugue Nicole , Cabrol Christine , Bernard Olivier A. 
Published: July 2010

AbstractEvolution to myelofibrosis (MF), acute myeloid leukemia or myelodysplastic syndrome (AML/MDS) may occur over time in myeloproliferative neoplasms (MPN) patients most likely due to the acquisition of additional mutations. The Groupe Francophone de cytogenetique hematologique (GFCH) has collected and reviewed 82 patients with transformation of MPN (66 AML/MDS and 16 MF). JAK2V617F and TET2 mutations were searched for in 40 and 32 patients, respectively. Significantly more −7/del(7q) (P = 0.004) and −5/del(5q) (P = 0.03) were found in AML/MDS with a higher incidence of dup1q (P = 0.01) in MF. Some specific chromosomal abnormalities occurred together, for example −5/del(5q) and −17/del(17p) (P = 0.0007). In multivariate analysis, two factors were independently associated with an inferior overall survival (OS); AML/MDS transformation (P < 0.0001) and −5/del(5q) abnormality (P = 0.02). Although both giving rise to loss of 7q, der(1;7) differed from other 7q deletions in terms of distribution (lower frequency of AML/MDS, P = 0.02), association with chromosomal abnormalities (absence of −5/del(5q), P = 0.003; increased del(20q), P = 0.05), and longer OS (P = 0.0007). We detected 24/40 (60%) JAK2V617F and 8/25 (32%) TET2 mutations in samples following transformation, ranging from wild‐type to mutated forms of both genes. The mutated and wild‐type forms of the genes were not found to be associated with a specific chromosomal abnormality. There was no evidence that JAK2 or TET2 mutations were associated with the type of MPN transformation, whereas the type of cytogenetic abnormalities were strongly linked, perhaps indicating that they play a specific role in the transformation process. © 2010 Wiley‐Liss, Inc.
Identification of genetic alterations in upper urinary tract urothelial carcinoma in end‐stage renal disease patients
Authors: Wu Ching‐Fang , Pang See‐Tong , Shee Jia‐Jen , Chang Phei‐Lang , Chuang Cheng‐Keng , Chen Chih‐Shou , Liao Shuen‐Kuei , Weng Wen‐Hui 
Published: July 2010

AbstractClinical presentations of end‐stage renal disease (ESRD) patients on dialysis with upper urinary tract urothelial carcinoma (UUT‐UC) are different from those with normal renal function. The pathogenesis remains unknown. We investigated the pathogenetic influence of chromosomal aberrations in patient on dialysis with UUT‐UC. The chromosomal aberrations of UUT‐UC specimens from seven dialysis patients were assessed by conventional comparative genomic hybridization (cCGH). Subsequently, we further investigated 20 cases by whole genome and fine‐tiling oligonucleotide array‐based CGH to demonstrate gains and losses, and compared with the clinicopathologic background. The chromosomal aberrations in UUT‐UC specimens from dialysis patients were more complex than in bladder urothelial carcinoma (B‐UC). Our data showed that gains at 5p, 7, 19q, and losses at 4q, 9p, and 15q are common in UUT‐UC of ESRD patients. Gains in regions associated with DNA repair genes were noted in this study. High‐stage and high‐grade tumors displayed more copy number variants. In addition, female ESRD patients with UUT‐UC had more frequent chromosomal aberrations than their male counterparts. In conclusion, unique chromosomal aberrations were indentified in UUT‐UC in ESRD patients. © 2010 Wiley‐Liss, Inc.
Identification of primary gene targets of TFAP2C in hormone responsive breast carcinoma cells
Authors: Woodfield George W. , Chen Yizhen , Bair Thomas B. , Domann Frederick E. , Weigel Ronald J. 
Published: July 2010

AbstractThe TFAP2C transcription factor is involved in mammary development, differentiation, and oncogenesis. Previous studies established a role for TFAP2C in the regulation of ESR1 (ERα) and ERBB2 (Her2) in breast carcinomas. However, the role of TFAP2C in different breast cancer phenotypes has not been examined in detail. To develop a more complete characterization of TFAP2C target genes, ChIP‐seq with anti‐TFAP2C antibody and expression arrays with TFAP2C knock down were analyzed in MCF‐7 breast carcinoma cells. Genomic sequences common to the ChIP‐seq data set defined the consensus sequence for TFAP2C chromatin binding as the nine base sequence SCCTSRGGS (S = G/C, r = A/G), which closely matches the previously defined optimal in vitro binding site. Comparing expression arrays before and after knock down of TFAP2C with ChIP‐seq data demonstrated a conservative estimate that 8% of genes altered by TFAP2C expression are primary target genes and includes genes that are both induced and repressed by TFAP2C. A set of 447 primary target genes of TFAP2C was identified, which included ESR1 (ERα), FREM2, RET, FOXA1, WWOX, GREB1, MYC, and members of the retinoic acid response pathway. The identification of ESR1, WWOX, GREB1, and FOXA1 as primary targets confirmed the role of TFAP2C in hormone response. TFAP2C plays a critical role in gene regulation in hormone responsive breast cancer and its target genes are different than for the Her2 breast cancer phenotype. © 2010 Wiley‐Liss, Inc.
Cruziana semiplicata from the Furongian (Late Cambrian) of Severnaya Zemlya Archipelago, Arctic Russia, with a review of the spatial and temporal distribution of this ichnospecies
Authors: Jensen Sören , Bogolepova Olga K. , Gubanov Alexander P. 
Published: July 2010

AbstractThe Furongian (Late Cambrian) Kurchavinskaya Formation of October Revolution Island, Severnaya Zemlya Archipelago, Arctic Russia, contains two distinctive morphotypes of the trace fossil Cruziana, both of which we assign to Cruziana semiplicata. A wider form shows characteristics typical of this ichnospecies with inner and outer lobes and marginal ridges. A narrow form has only an inner lobe with siculate, often interfering scratch‐marks, and rare, narrow marginal ridges. This narrow form, which shows characters in common with Cruziana tortworthi, probably represents burrowing in a strongly head‐down orientation. The record from October Revolution Island provides additional evidence that the palaeogeographical distribution of Cruziana semiplicata is not restricted to Gondwana, but also extend to parts of Baltica and North Kara. Cruziana semiplicata is known from the Furongian and Tremadocian of Gondwana, whereas on Baltica it is known only from the Furongian. Copyright © 2010 John Wiley & Sons, Ltd.
Coping processes and health‐related quality of life in Parkinson's disease
Authors: Bucks R. S. , Cruise K. E. , Skinner T. C. , Loftus A. M. , Barker R. A. , Thomas M. G. 
Published: July 2010

AbstractObjectiveThis study investigated the predictive value of various coping processes for the psychological and disease specific aspects of health‐related quality of life (HRQoL) in Parkinson's disease (PD).MethodCross‐sectional study of 85 participants with PD using the Ways of Coping Questionnaire (WCQ), Depression, Anxiety, and Stress Scale (DASS‐21), quality of life (PDQ‐39), and socio‐demographic and clinical variables.ResultsGreater use of planful problem solving coping was found to be significantly associated with better HRQoL in relation to cognitive impairment, communication and bodily discomfort. In addition to greater disease duration, greater use of escape‐avoidance coping processes were identified as significant predictors of poorer HRQoL outcomes in the domains of mood and emotional well‐being.ConclusionPsychological interventions such as mindfulness training, aimed at reducing the use of escape‐avoidance copying, may help to improve HRQoL in PD. Copyright © 2010 John Wiley & Sons, Ltd.
Malignant fibrous histiocytoma of the head and neck region
Authors: Clark David W. , Moore Brian A. , Patel Shreyaskumar R. , Guadagnolo B. Ashleigh , Roberts Dianna B. , Sturgis Erich M. 
Published: July 2010

AbstractBackgroundMalignant fibrous histiocytoma (MFH) is 1 of the most common soft tissue sarcomas in the head and neck.MethodsWe conducted a retrospective review of patients with MFH of the head and neck region at a large multidisciplinary cancer center between 1973 and 2005.ResultsNinety‐five patients were included in the study. The median age at diagnosis was 53 years (range, 3–90 years); 69% of the patients were men. The parotid or neck was the most common subsite (35%), and 23% of the cases were associated with prior radiation exposure. Although there were no significant differences in the distribution of age, sex, year of presentation, tumor location, size, local extension, or treatment between patients with and without prior radiation exposure, those with radiation‐associated tumors were more likely to have positive or unclear surgical margins (p = .037). With a median follow‐up of 34 months, 32 (39%) of the 83 patients treated at M. D. Anderson Cancer Center with curative intent had a recurrence (isolated local recurrence in 18, isolated distant recurrence in 8, both local and distant recurrence in 5, and regional recurrence in 1). For patients treated at our institution with curative intent, 5‐year overall, disease‐free, and disease‐specific survival rates were 55%, 44%, and 69%, respectively. Prior radiation exposure and positive margins were associated with worse survival.ConclusionMFH of the head and neck region is often aggressive and characterized by local and/or distant recurrence and poor survival. Radiation‐associated tumors seem to have an especially poor prognosis. Based on a significant body of literature, multidisciplinary evaluation and treatment of such high‐grade sarcomas is encouraged. © 2010 Wiley Periodicals, Inc. Head Neck, 2010
Transoral robotic‐assisted thyroidectomy: A preclinical feasibility study in 2 cadavers
Authors: Richmon Jeremy D. , Pattani Kavita M. , Benhidjeb Tahar , Tufano Ralph P. 
Published: July 2010

AbstractBackgroundTechnological advances in thyroid surgery have included various “minimally invasive” thyroidectomy techniques, both open and endoscopic. These include not only minimally invasive video‐associated approaches but also variations of the transaxillary approach. More recently, a transoral technique using video assistance has been reported for thyroidectomy. Use of the robot was also recently published in a transaxillary approach to the thyroid. We hypothesized that the robot in combination with the previously described transoral technique would facilitate this novel surgical approach.MethodsIn 2 human cadavers the da Vinci robot was used to perform a transoral thyroidectomy. The dissection was performed with successful removal of the thyroid gland through the floor of the mouth.ResultsA total thyroidectomy was performed in 2 cadavers using the da Vinci robot transoral technique. The recurrent laryngeal nerve was preserved.ConclusionsTransoral robotic‐assisted thyroidectomy (TRAT) provides an attractive approach to the central compartment for thyroidectomy in a field of “minimally invasive” and “scarless” techniques. © 2010 Wiley Periodicals, Inc. Head Neck, 2010
Tumor volume as prognostic factor in chemoradiation for advanced head and neck cancer
Authors: Knegjens Joost L. , Hauptmann Michael , Pameijer Frank A. , Balm Alfons J. , Hoebers Frank J. , de Bois Josien A. , Kaanders Johannes H. , van Herpen Carla M. , Verhoef Cornelia G. , Wijers Oda B. , Wiggenraad Ruud G. , Buter Jan , Rasch Coen R. 
Published: July 2010

AbstractBackgroundTumor volume is an important predictor of outcome in radiotherapy alone. Its significance in concomitant chemoradiation (CCRT) is much less clear. We analyzed the prognostic value of primary tumor volume for advanced head and neck squamous cell carcinoma (HNSCC) treated with CCRT.MethodsThree hundred sixty patients treated with definitive CCRT for advanced HNSCC were selected. The pretreatment MRI or CT scan was used to calculate the primary tumor volume. Median follow‐up was 19.8 months.ResultsThe average primary tumor volume was 37.0 cm3 (range, 2.1–182.7 cm3; median, 28.7 cm3). Multivariate analysis showed a significant effect of tumor volume on local control. The hazard ratio for a local recurrence increased by 14% per 10 cm3 volume increase (95% CI, 8% to 21%). There was no significant independent effect of T and N status on local control.ConclusionFor advanced HNSCC, tumor volume is more powerful for predicting outcome after CCRT than TNM status. © 2010 Wiley Periodicals, Inc. Head Neck, 2010
Submandibular salivary gland transfer for the prevention of radiation‐induced xerostomia in patients with nasopharyngeal carcinoma: 5‐Year outcomes
Authors: Liu Xue‐Kui , Su Yong , Jha Naresh , Hong Ming‐Huan , Mai Hai‐Qiang , Fan Wei , Zeng Zong‐Yuan , Guo Zhu‐Ming 
Published: July 2010

AbstractBackgroundOur aim in this study was to investigate the value of the submandibular salivary gland transfer procedure in prevention of radiation‐induced xerostomia in patients with nasopharyngeal carcinoma (NPC).MethodsIn all, there were 70 patients, consisting of a test group (36 patients) and a control group (34 patients) in a nonrandomized fashion. In the test group, the submandibular salivary gland was transferred to submental space before radiotherapy (XRT) and shielded. Salivary gland functions were evaluated by the amount of saliva and a quality of life questionnaire before and after XRT and 3 and 60 months after XRT.ResultsAt 5 years, the trapping and excretion functions of salivary gland were significantly better in the test group (p = .000 and p = .000). The mean weight of saliva after XRT was heavier (1.65 g vs 0.73 g, p = .000), and the incidence of xerostomia was lower in the test group, with no difference in 5‐year survival and neck nodal recurrence between the 2 groups.ConclusionsSalivary gland transfer procedure prevents XRT‐induced xerostomia and improves quality of life of patients with NPC. © 2010 Wiley Periodicals, Inc. Head Neck, 2010
Acute exposure of rabbits to diphenyl diselenide: a toxicological evaluation
Authors: Straliotto Marcos Raniel , Mancini Gianni , de Oliveira Jade , Nazari Evelise Maria , Müller Yara Maria Rauh , Dafre Alcir , Ortiz Susana , Silva Edson Luiz , Farina Marcelo , Latini Alexandra , Rocha João Batista Teixeira , de Bem Andreza Fabro 
Published: July 2010

AbstractThe simple organoselenium compound diphenyl diselenide (PhSe)2is a promising new pharmacological agent. However, few toxicological evaluations of this molecule have been reported. We evaluated the effects of acute administration of (PhSe)2on toxicological parameters in rabbits. Adult New Zealand rabbits were exposed to (PhSe)2(5–500 µmol kg−1, intraperitoneally) once a day for 5 days. Exposure to 500 µmol kg−1caused 85% mortality. Exposure to 50 µmol kg−1of (PhSe)2increased the glutathione levels in the hippocampus, kidney, heart, muscle and blood, whereas lipoperoxidation (TBARS) decreased in the cerebellum and kidney after exposure to 5 µmol kg−1. The activity of glutathione peroxidase increased in the heart and muscle of rabbits treated with 50 µmol kg−1of (PhSe)2and glutathione reductase activity was reduced in the cerebellum, cerebral cortex and kidney. Treatment with (PhSe)2reduced the activity ofδ‐aminolevulinate dehydratase in the hippocampus and increased this activity in the heart, but did not alter the activity of complexes I and II of the respiratory chain in the liver and brain. Hepatic and renal biochemical and histological parameters were not modified by (PhSe)2and apoptosis was not detected in these tissues; however, the hepatic cells tended to accumulate fat vacuoles. These results indicated that acute toxicology to (PhSe)2in rabbit is dependent on the dose, which should motivate further experiments on the therapeutic properties of this compound. Copyright © 2010 John Wiley & Sons, Ltd.
Effect of shell thickness and composition on blinking suppression and the blinking mechanism in ‘giant’ CdSe/CdS nanocrystal quantum dots
Authors: Vela Javier , Htoon Han , Chen Yongfen , Park Young‐Shin , Ghosh Yagnaseni , Goodwin Peter M. , Werner James H. , Wells Nathan P. , Casson Joanna L. , Hollingsworth Jennifer A. 
Published: July 2010

AbstractWe recently developed an inorganic shell approach for suppressing blinking in nanocrystal quantum dots (NQDs) that has the potential to dramatically improve the utility of these fluorophores for single‐NQD tracking of individual molecules in cell biology. Here, we consider in detail the effect of shell thickness and composition on blinking suppression, focusing on the CdSe/CdS core/shell system. We also discuss the blinking mechanism as understood through profoundly altered blinking statistics. We clarify the dependence of blinking behavior and photostability on shell thickness, as well as on interrogation times. We show that, while the thickest‐shell systems afford the greatest advantages in terms of enhanced optical properties, thinner‐shell NQDs may be adequate for certain applications requiring relatively shorter interrogation times. Shell thickness also determines the sensitivity of the NQD optical properties to aqueous‐phase transfer, a critical step in rendering NQDs compatible with bioimaging applications. Lastly, we provide a proof‐of‐concept demonstration of the utility of these unique NQDs for fluorescent particle tracking. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Crosslinked urethane doped polyester biphasic scaffolds: Potential for in vivo vascular tissue engineering
Authors: Dey Jagannath , Xu Hao , Nguyen Kytai Truong , Yang Jian 
Published: July 2010

AbstractIn vivo tissue engineering uses the body as a bioreactor for tissue regeneration, thus placing stringent requirements on tissue scaffolds, which should be mechanically robust for immediate implantation without a long in vitro cell culture time. In addition to mechanical strength, vascular grafts fabricated for in vivo tissue engineering approach must have matching mechanical properties to the target tissues to avoid compliance mismatch, which is one of the reasons for graft failure. We recently synthesized a new generation of strong and elastic biodegradable crosslinked urethane‐doped polyesters (CUPE) to address the challenge of developing soft, elastic yet strong biodegradable polymers. This study evaluated the tensile strength, burst pressure, and suture retention of CUPE biphasic scaffolds to determine if the scaffolds met the requirements for immediate implantation in an in vivo tissue engineering approach. In addition, we also examined the hemocompatibility and inflammatory potential of CUPE to demonstrate its potential in serving as a blood‐contacting vascular graft material. Tensile strength of CUPE biphasic scaffolds (5.02 ± 0.70 MPa) was greater than native vessels (1.43 ± 0.60 MPa). CUPE scaffolds exhibited tunable burst pressure ranging from 1500 mmHg to 2600 mmHg, and adequate suture retention values (2.45 ± 0.23 N). CUPE showed comparable leukocyte activation and whole blood clotting kinetics to poly(L‐lactic acid) PLLA. However, CUPE incited a lesser release of inflammatory cytokines and was found to be non hemolytic. Combined with the mechanical properties and previously demonstrated anti‐thrombogenic nature, CUPE may serve as a viable graft material for in vivo blood vessel tissue engineering. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010.