bluuebunny/crossref_metadata_2025_split huggingface dataset:
UV to NIR Broadband Flexible Photodetector Based on Solution‐Processed MoS2/PDPP3T Inorganic–Organic Hybrid Heterostructures
Authors: Tang Daxiu , Du Zhenyu , Xie Ying , Zhao Feiyu , Yang Xiangdong , Gu Chenjie , Shen Xiang 
Published: April 2024

AbstractMolybdenum disulfide (MoS2) is a 2D material with excellent electrical and optical properties, and developing a universal technology for the preparation of high‐performance MoS2‐based photodetector is extremely desirable. Here, a UV to NIR broadband flexible photodetector based on MoS2/(PDPP3T) inorganic–organic hybrid heterostructures is reported. In the experiment, high crystalline 2H‐phase few‐layer MoS2 nanoflakes are first prepared by optimized electrochemical intercalation of tetraheptylammonium cation (THA+) and ultrasound‐assisted exfoliation strategy. Thereafter, a narrow bandgap organic semiconductor PDPP3T is introduced to construct the MoS2/Poly(diketopyrrolopyrrolothiophrn) (PDPP3T) heterojunction. Experimental results reveal that the photodetector can have broadband photo response from 380 to 980 nm. Meanwhile, excellent responsivities and detectivity of 12.4 mA W−1, 2.2 × 1010 Jones at 380 nm and 0.1 mA W−1 and 5 × 108 Jones at 980 nm are achieved, which are ≈10 (UV band)/100 (NIR band) times high than that obtained on the pure MoS2‐based detector. Moreover, the flexibility of the device is investigated by conformal covering the device on a curved surface (R = 5 and 2.5 mm), it shows that the photo response remains almost the same as that measured on the planar substrate, indicating the possible application in the wearable electronics.
Boron Removal Using Spherulitic Polyamide Organic–Inorganic Thin‐Film Nanocomposite Desalination Membranes
Authors: Ee Liang Ying , Chia Sean Yi Rong , Li Sam Fong Yau 
Published: April 2024

AbstractThis research investigates the development of ultrathin polyamide (PA) desalination membranes via electrospray fabrication, balancing the trade‐offs between selectivity and permeability. The unique contribution to the improvement of desalination performance is the integration of protonated montmorillonite nanoclay (MMT‐H+) and hyperbranched amino‐polyol cellulose nanocrystals (APCNC) as co‐nanofillers during the in situ interfacial polymerization process. Synergistic effect of the nanofillers is demonstrated in the resultant spherulitic PA thin‐film nanocomposite (TFN) membrane, achieving salt rejection of up to 99.7% against simulated brackish water. Moreover, the membrane's superior boron removal efficiency at neutral pH, observed at 76.7% in a single‐stage desalination process, is attributed to the reduced membrane pore size, disruption of water‐boron association by the spherulites, and complexation and electrostatic interaction with the abundant hydroxyl and amine groups along the APCNC polymeric chains. This process eliminates the need for pH adjustment, thereby enhancing the membrane's practicality and efficiency. The findings of this study provide significant insights into the interactions between boron and the membrane surface, laying the groundwork for the development of effective TFN desalination membranes for water purification and boron removal. The implication of these findings extends beyond academic interest, offering a promising strategy for addressing the global water scarcity crisis.
In situ impregnation of cobalt‐doped tungstophosphoric acid on MOF‐801 toward enhanced catalytic activity for esterification
Authors: Zhang Qiuyun , Hu Mengmeng , Chen Fan , Lei Jiao , Cheng Jingsong , Ma Juan , Zhao Yongting , Zhang Yutao 
Published: April 2024

Development of an energy‐efficient and economical route is necessary for society to synthesize green biofuels. Herein, cobalt‐doped tungstophosphoric acid (Co‐HPW) is in‐situ impregnated in the Zr‐based metal–organic framework (MOF‐801) forming composite of Co‐HPW/MOF‐801. The chemical composition, morphology, and acidic sites of the Co‐HPW/MOF‐801 composite were analyzed through x‐ray diffractometer (XRD), Fourier transform infrared (FTIR), scanning electron microscope (SEM), energy‐dispersive x‐ray spectroscopy (EDS), thermogravimetric analysis (TG), N2 physisorption, ammonia temperature‐programmed desorption (NH3‐TPD), pyridine‐adsorbed infrared spectra (Py‐FTIR), and x‐ray photoelectron spectroscopy (XPS). The catalytic performance of the as‐synthesized catalyst was explored to catalyze esterification of lauric acid (LA) with methanol. The outcomes revealed that the Co‐HPW/MOF‐801 nanocatalyst achieved a high conversion of 86.3% under the optimized reaction condition (catalyst amount of 0.15 g, temperature of 100°C, time of 4 h, and methanol/LA molar ratio of 20:1). The excellent catalytical performance is mainly due to the large BET surface area, exposure of more active centers from available pore structure, and simultaneous possession of high Lewis and Brønsted acidity. Furthermore, the kinetic study revealed that the reaction process was kinetically controlled and the activation energy was found to be 42.1 kJ/mol. The results suggest that the synthesized Co‐HPW/MOF‐801 nanocatalyst is an environmental greenness, low cost, and suitable for easy scale‐up for the production of biofuels.
Limonoids isolated from Chisocheton ceramicus Miq. and the antiadipogenic mechanism of action of ceramicine B
Authors: Bailly Christian 
Published: April 2024

AbstractDifferent types of limonoids have been isolated from plants of the Chisocheton genus, notably from the species Chisocheton ceramicus Miq. which is largely distributed in the Indonesian archipelago and Malaysia region. A variety of natural products have been found in the bark of the tree and characterized as antimicrobial and/or antiproliferative agents. The isolated limonoids include chisomicines A–E, proceranolide, and a few other compounds. A focus is made on a large series of limonoids designated ceramicines A to Z including derivatives with antiparasitic activities, antioxidant, antimelanogenic, and antiproliferative effects and/or acting as regulators of lipogenesis. The lead compound in the series is ceramicine B functioning as a potent inhibitor of lipid droplet accumulation (LDA). Extracts from Chisocheton ceramicus and ceramicines have shown anti‐LDA effects, with little or no cytotoxic effects. Ceramicine B is the most active compound functioning as a regulator of lipid storage in cells and tissues. Ceramicine B is a transcriptional repressor of peroxisome proliferator‐activated receptor γ (PPARγ) and an inhibitor of phosphorylation of the transcription factor FoxO1, acting via an upstream molecular target. Targeting of glycogen synthase kinase‐3β is proposed, based on the analogy with structurally related limonoids known to target this enzyme, and supported by a molecular docking analysis. The target and pathway implicated in ceramicine B activity are discussed. The analysis shed light on ceramicine B as a natural product precursor for the design of novel compounds capable of reducing LDA in cells and of potential interest for the treatment of obesity, liver diseases, and other pathologies.
Bioprocess in‐line monitoring and control using Raman spectroscopy and Indirect Hard Modeling (IHM)
Authors: Müller David Heinrich , Börger Marieke , Thien Julia , Koß Hans‐Jürgen 
Published: April 2024

AbstractProcess in‐line monitoring and control are crucial to optimize the productivity of bioprocesses. A frequently applied Process Analytical Technology (PAT) tool for bioprocess in‐line monitoring is Raman spectroscopy. However, evaluating bioprocess Raman spectra is complex and calibrating state‐of‐the‐art statistical evaluation models is effortful. To overcome this challenge, we developed an Indirect Hard Modeling (IHM) prediction model in a previous study. The combination of Raman spectroscopy and the IHM prediction model enables non‐invasive in‐line monitoring of glucose and ethanol mass fractions during yeast fermentations with significantly less calibration effort than comparable approaches based on statistical models. In this study, we advance this IHM‐based approach and successfully demonstrate that the combination of Raman spectroscopy and IHM is capable of not only bioprocess monitoring but also bioprocess control. For this purpose, we used this combination's in‐line information as input of a simple on–off glucose controller to control the glucose mass fraction inSaccharomyces cerevisiaefermentations. When we performed two of these fermentations with different predefined glucose set points, we achieved similar process control quality as approaches using statistical models, despite considerably smaller calibration effort. Therefore, this study reaffirms that the combination of Raman spectroscopy and IHM is a powerful PAT tool for bioprocesses.
Listening to life: Sonification for enhancing discovery in biological research
Authors: Braun Rhea , Tfirn Maxwell , Ford Roseanne M. 
Published: April 2024

AbstractSonification, or the practice of generating sound from data, is a promising alternative or complement to data visualization for exploring research questions in the life sciences. Expressing or communicating data in the form of sound rather than graphs, tables, or renderings can provide a secondary information source for multitasking or remote monitoring purposes or make data accessible when visualizations cannot be used. While popular in astronomy, neuroscience, and geophysics as a technique for data exploration and communication, its potential in the biological and biotechnological sciences has not been fully explored. In this review, we introduce sonification as a concept, some examples of how sonification has been used to address areas of interest in biology, and the history of the technique. We then highlight a selection of biology‐related publications that involve sonifications of DNA datasets and protein datasets, sonifications for data collection and interpretation, and sonifications aimed to improve science communication and accessibility. Through this review, we aim to show how sonification has been used both as a discovery tool and a communication tool and to inspire more life‐science researchers to incorporate sonification into their own studies.
Superhomicide offenders: Nosology, empirical features, and linkages to sexual and multiple murder typologies
Authors: DeLisi Matt 
Published: April 2024

AbstractThe nosology for criminals who murder multiple victims is at once well‐established and controversial, perhaps because theorists have largely segregated such offenders from the broader criminal population. The current study introduces the superhomicide offender, an individual convicted of at least five murders, to locate multiple homicide offenders within the criminological and epidemiological science pertaining to the most pathological offenders, and statistically place them with other conceptualizations of severe offenders at the 95th percentile of the offending distribution. Relative to other capital murderers, superhomicide offenders have lengthier criminal history, greater conviction history, and coextensive psychopathology characterized by psychopathy, sexual sadism, homicidal ideation, cluster A and B personality disorders, and major depressive disorder. Superhomicide offenders are profoundly psychopathic with 20 of the 39 offenders reaching the clinical threshold of 30 or more on the PCL‐R, and 19 of the 39 are sexually sadistic. Regarding extant typologies of sexual and multiple homicide offenders, 15 are serial murderers, 17 are sexual homicide offenders, 17 are mass murderers, and 17 are spree murderers. Twenty‐four of the 39 superhomicide offenders (61.5%) met criteria for multiple typologies, suggesting the new prototype can help unify the study of those who perpetrate multicide and embed them within criminological and epidemiological models that specify pathological antisocial outcomes.
Electroosmotic Flow in Fractal Tree‐Like Convergent Microchannel Network
Authors: Jing Dalei , Qi Peng 
Published: April 2024

AbstractElectroosmotic flow (EOF) in a fractal tree‐like microfluidic network has wide applications. To reduce the fluid resistance of EOF in the network, this paper numerically studies the influences of the branch convergence α, the level convergence κ, the length ratio λ, the branching number N, the maximum branching level M, and the channel height H of a fractal tree‐like convergent microchannel network (FTCMCN) on the EOF flowrate and analyzes the optimal structure of FTCMCN to maximize the EOF transport efficiency. The present paper finds the optimal structure of FTCMCN and its dependence on the various geometric and structural parameters. This work is beneficial to the optimization design of the FTCMCN to achieve the highest EOF transport efficiency.
Influence of the Replenishment Methods of the Sending Tanks on Pneumatic Conveying Characteristics
Authors: Zhou Jiawei , Yan Xiangyu , Guo Xiaole , Zheng Zebing , Wang Qinghui , Wang Yingjia 
Published: April 2024

AbstractData on pressure signals and gas flow rate signals was collected under various experimental conditions. A comparative analysis was conducted to investigate the gradient changes of the fluidizing gas, the supplemental gas, and the pressurizing gas. A three‐factor three‐level orthogonal experiment was carried out. The results demonstrated that the proper use of the fluidizing gas can enhance the steady condition of the conveying process. Increasing the flow rate of the supplemental gas can improve the steady flow pattern, while the pressurizing gas has the opposite effect. The degree of influence of these parameters on the steady condition of the conveying process was shown to follow the order of fluidizing gas valve opening, pressurizing gas valve opening, and regulating gas valve opening.
Gasification Reaction on CeO2(111) and Effects on the Structural and Electronic Properties of Adsorption Molecules
Authors: James Rubinsin Nowilin , Timmiati Sharifah Najiha , Lim Kean Long , Isahak Wan Nor Roslam Wan , Karim Nabila A. 
Published: April 2024

AbstractProducing hydrogen (H2) from biomass gasification offers exceptional benefits regarding renewable energy sources, zero‐carbon emission, cost‐effective processes, and high efficiency. The addition of catalysts to biomass gasification could accelerate the process and minimize the formation of coke. However, the catalyst deactivation caused by carbon deposition, poisoning, and sintering is still a significant problem in the gasification process. Therefore, achieving sustainable exploitation of the renewable natural resource of biomass requires substantial development and optimization of the present gasification process. The efficiency of gasification might decrease because of such a process. In this study, CeO2(111) is chosen to investigate the analysis of adsorption molecules during catalytic gasification using the density functional theory method. Three catalyst models, CeO2(111), Zr‐CeO2(111), and Ni‐CeO2(111), have been studied in this work in terms of structural, electronic, and adsorption molecule properties. The structural and electronic properties of the modified catalyst model show the ligand and strain effect on the alloy, with the addition of Zr and Ni as second metals promoting the adsorption capability. Searching for active sites is also carried out by adsorption of selected atoms and molecules and used as a preliminary study to find possible active sites for gasification reactions. The Zr‐CeO2(111) and Ni‐CeO2 catalysts exhibit better adsorption ability on atomics and molecules. The Zr and Ni metals are suitable second metal candidates for the catalyst to proceed with the gasification reaction and simultaneously reduce carbon deposition, poisoning, and sintering problems.
Luminescence and Energy Transfer Properties of Color‐Tunable Dy3+, Eu3+ co‐Activated NaGdSiO4 Phosphor for WLED with Great Thermo‐Stability
Authors: Wang Xihu , Wang Xuyang , Chai Xiaona , Li Jun , Hu Jinyu 
Published: May 2024

AbstractA series of NaGd1‐x–ySiO4: y Dy3+–x Eu3+ phosphors were synthesized by a high‐temperature solid‐phase method. The optimal doping ion concentration of Dy3+ ions for this phosphor was determined to be 1 % from the emission spectra. The energy transfer between Dy3+ and Eu3+ ions at 351 nm was investigated by photoluminescence spectra and fluorescence decay curves. At the excitation wavelengths of 275 nm, 351 nm, 366 nm, and 394 nm, a change from yellow to white to red light can be realized by adjusting the doping concentration of Eu/Dy ions. Particularly, by testing the temperature‐dependent fluorescence spectrum of the phosphor, it can be found that the luminous intensity of the phosphor is as high as 96 % when 394 nm excitation is employed at 413 K. It was the maximum at this temperature comparing with other phosphors as far as we know. The color coordinate values show that the NaGd1‐x–ySiO4:×Dy3+–y Eu3+ phosphors are very close to the white light color coordinates (x=0.33, y=0.33) under 351 nm excitation. Meanwhile, the correlated color temperature is between 5062–7104 K. These results indicate that this phosphor is a promising candidate for high‐quality WLED.
Comparisons of successful and failed Phase III trials of drugs and biologicals tested for mitigation of oral mucositis in patients being treated with radiotherapy with or without concomitant chemotherapy for cancers of the head and neck
Authors: Liang Lang , Sonis Stephen T. 
Published: April 2024

AbstractOral mucositis (OM) remains a significant toxicity among patients being treated with radiotherapy (RT) alone or with concomitant chemotherapy (CRT) for cancers of the head and neck (HNC). Given its clinical significance as an unmet need and its potential commercial viability, the pharmaceutical industry has been actively pursuing an effective intervention. Despite this interest and activity, only a few agents have been studied in Phase III trials (n = 6). The objective of this study was to identify common features that differentiate successful and failed Phase III OM trials. We used the United States Patent and Trademark Office Patent Public Search database to search patents with “oral mucositis” in the claims. We then searched ClinicalTrials.gov and PubMed to determine if Phase III or Phase II trial data for identified biologics/drugs had been published. We assessed each Phase III and Phase II trial for characteristics that may be associated with trial success or failure. We considered a study as a “success” if the primary endpoint reached statistical significance, and we considered a study as “failure” if the primary endpoint did not reach statistical significance. Of the three successful Phase III trials, one investigated avasopasem manganese (Galera Therapeutics) and two examined palifermin (Amgen). The three failed trials included those evaluating dusquetide (Soligenix), iseganan hydrochloride (IntraBiotics Pharmaceuticals), and clonidine (Monopar Therapeutics). We found that differences in the level of sponsor funding, patient inclusion criteria including radiation source and concomitant chemotherapy regimen, and concordance of primary efficacy outcomes between Phase II and Phase III trials influenced outcomes. To properly design clinical trials for OM in HNC patients, it is important that researchers and sponsors take note of specific study characteristics associated with success or failure, particularly with Phase III trials where the risks and costs are the highest.
Chitosan‐coated nanoparticles in innovative cancer bio‐medicine
Authors: Rezaei Niloufar , Zarkesh Ibrahim , Fotouhi Alireza , Alikhani Hani Keshavarz , Hassan Moustapha , Vosough Massoud 
Published: April 2024

AbstractIn the recent decade, nanoparticles (NPs) have had enormous implications in cancer biomedicine, including research, diagnosis, and therapy. However, their broad application still faces obstacles due to some practical limitations and requires further development. Recently, there has been more interest in the coated class of nanoparticles to address those challenges. Chitosan‐coated NPs are simple to produce, biodegradable, biocompatible, exhibit antibacterial activity, and have less cytotoxicity. This study provides an updated and comprehensive overview of the application of chitosan‐coated NPs as a promising class of NPs in cancer biomedicine. Additionally, we discussed chitosan‐coated lipid, metal, and polymer‐based nanoparticles in biomedical applications. Furthermore, different coating methods and production/characterization procedures were reviewed. Moreover, the biological and physicochemical advantages of chitosan‐coated NPs, including facilitated controlled release, greater physicochemical stability, improved cell/tissue interaction, and enhanced bioavailability of medications, were highlighted. Finally, the prospects of chitosan‐coated NPs in cancer biomedicine were discussed.
Anti‐NSCLC role of SCN4B by negative regulation of the cGMP‐PKG pathway: Integrated utilization of bioinformatics analysis and in vitro assay validation
Authors: Yang Xiujun , Liu Qun , Li Gang 
Published: April 2024

AbstractNon‐small cell lung cancer (NSCLC) is a malignant tumor with low overall cure and survival rates. Uncovering abnormally expressed genes is significantly important for developing novel targeted therapies in NSCLC. This study aimed to discover new differentially expressed genes (DEGs) of NSCLC. The DEGs of NSCLC were identified in eight data sets from Gene Expression Omnibus (GEO) database. The expression profiles and the prognostic significance of SCN4B in LUAD and LUSC were analyzed using GEPIA database. LinkedOmics was used to identify co‐expressed genes with SCN4B, which were further subjected to KEGG pathway enrichment analysis. SCN4B‐overexpressing plasmid (pcDNA/SCN4B) was transfected into A549 and NCI‐H2170 cells to elevate the expression of SCN4B. MTT and TUNEL assays were performed to evaluate cell viability and apoptosis. Relying on the screened DEGs from GEO database, we identified that SCN4B was significantly downregulated in LUAD and LUSC. We confirmed the downregulation of SCN4B in NSCLC tissues using GEPIA database. SCN4B has a prognostic value in LUAD, but not LUSC. KEGG pathway enrichment analysis of SCN4B‐related genes showed that cGMP‐PKG signaling pathway might be involved in the role of SCN4B in NSCLC. Overexpression of SCN4B in A549 and NCI‐H2170 cells inhibited the cell viability. Besides, SCN4B overexpression induced apoptosis of A549 and NCI‐H2170 cells. SCN4B inhibited the expression of PKG1 and p‐CREB in NSCLC cells. Moreover, the inhibitory effects of SCN4B on tumor malignancy were attenuated by the activator of PKG. In conclusion, integrated bioinformatical analysis proved that SCN4B was downregulated and had a prognostic significance in NSCLC. In vitro experimental studies demonstrated that SCN4B regulated NSCLC cells viability and apoptosis via inhibiting cGMP‐PKG signaling pathway.