bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kajian Empiris dan Etnofarmasi Tumbuhan Hutan Berkhasiat Obat Asal Desa Adat Tenganan Pegringsingan Karangasem Bali sebagai Antinyeri dan Antiinflamasi
Authors: Nita Ni Luh Kade Arman Anita Dewi , Gusti Ayu Putri Cantika Dewi  , Megawati Fitria , Megawati Putu Era Sandhi Kusuma Yuda , Megawati Erna Cahyaningsih 
Published: June 2024

Etnofarmasi adalah multidisiplin ilmu yang menghubungkan ilmu kefarmasian dengan adat budaya masyarakat yang terdiri dari obat dan cara menggunakan bahan alam untuk pengobatan berdasarkan ciri khas komunitas etnik suatu daerah di Desa Adat Tenganan Pegringsingan Karangasem pada pengobatan nyeri dan inflamasi. Tujuan penelitian ini adalah mengetahui pemanfaatan tanaman obat beserta bagian tanaman, cara pengolahan, cara penggunaannya yang digunakan dalam pengobatan nyeri dan inflamasi serta mengetahui indeks kegunaan (use value) dan fidelity level (FL) tanaman hasil studi etnofarmasi dan mengetahui potensi tanaman lain yang ada di Hutan Desa Adat Tenganan Pegringsingan Karangasem. Penelitian ini dilakukan dengan metode survei/observational dan pemilihan responden secara snowball sampling, yaitu mencari responden yang dianggap memiliki pengetahuan mengenai pengobatan tradisional. Penelitian kualitatif digunakan dengan metode wawancara dan penyajian data dan untuk kuantitatif dengan indeks kegunaan. Pada penelitian ini menggunakan variabel mandiri, yaitu studi etnofarmasi sebagai pengobatan nyeri dan inflamasi di Hutan Desa Adat Tenganan Pegringsingan Karangasem. Proses pengumpulan data dilakukan dengan pengamatan langsung, yaitu mengamati, mendengar, mencatat dan mempelajari dari narasumber. Perhitungan hasil dilakukan dengan rumus Use value (UV) dan Fidelity Level (FL). Berdasarkan hasil wawancara yang telah dilakukan dengan kedua narasumber yang telah memenuhi kriteria inklusi didapatkan hasil wawancara 12 jenis tanaman obat yang digunakan oleh narasumber sebagai pengobatan nyeri dan inflamasi. Terdapat 26 jenis tanaman obat yang berasal dari hutan desa adat yang tidak digunakan oleh narasumber dalam pengobatan namun tanaman tersebut memiliki khasiat dalam pengobatan nyeri dan inflamasi. Tanaman tersebut berasal dari Hutan Desa Adat Tenganan Pegringsingan Karangasem serta berasal dari sekitar lingkungan pekarangan dari narasumber.
पिँजराको प्यासा मैना कवितामा निहितार्थ {Implications in the poem Pinjarako Pyasa of the cage}
Authors: अधिकारी Adhikari अनिल Anil 
Published: June 2024

यो लेख पिँजराको प्यासा मैना कवितामा निहितार्थ विश्लेषणसँग सम्बन्धित छ भने यसमा सोही विषयलाई मुख्य समस्या चयन गरी प्रतिकात्मकता, सांसारिकता, क्रियाकलाप, सामाजिक, सांस्कृतिक, सम्बन्धगत र उपादेयता निर्मितिजस्ता शोध्यसमस्या निर्धारित छन् । गुणात्मक अनुसन्धानविधि र पाठविश्लेषणकेन्द्री ढाँचामा तयार गरिएको यस लेखमा विश्लेषणको सिद्धान्त निहितार्थ हो । निहितार्थ सङ्कथनमा रहेका सबै क्षेत्रसम्बद्ध रचनाको विश्लेषण गर्ने संरचनावादी भाषापरक अध्ययन पद्धति हो । पाठनिर्मापक एकाइका रूपमा भाषाले निर्माण गर्ने सन्दर्भका विविधस्वरूप तथा तिनको पारस्परिक अन्वयबाट प्रतिपादन हुने केन्द्रीय अर्थ नै निहितार्थ हो भने मुक्तकाकार पिँजराको प्यासा मैना कविता निहितार्थका कोणबाट अध्ययनीय सामग्री हो । सटीक र सारपूर्ण प्रतीक प्रयोग तथा त्यसकै अन्तर्यमा निर्माण भएको सांसारिकता र क्रियाकलाप कविताको केन्द्रीय अर्थनिर्मापक आधार बनेका छन् । नेपाली समाजको तत्कालीन सामाजिक र सांस्कृतिक निर्मितिको अभिव्यञ्जना रहेको यस कवितामा शब्दले निर्माण गर्ने सन्दर्भको पारस्परिक अन्वय संसक्ति र संयुक्तिगत रूपमा सशक्त रहेको छ । मानव बन्धकको उत्कर्ष रहेको समाज र सामाजिक व्यवहारबाट पार्थक्य लिई निर्वेदको अभिलाषा अभिव्यञ्जित यस कवितामा नेपाली समाजको वस्तुता प्रस्तुत गर्नु उपादेयता निर्मिति रहेको विषयमा विमर्श भएको छ ।
SAFE LOCK SECURITY PROTOTYPE USING FINGERPRINT AND PIN
Authors: Zain Abdul , Amar Muh Ikhsan , Resky Aprizal , Putriani Andi Ika , Imansyah Nur 
Published: June 2024

In general, security safe box is currently still using key combination that has some drawbacks. One of the weaknesses is the risk of lossing of the keys and forgetting the lock codes that impact at users of not being able to operate the safe box. Therefore, the researcher is designing a tool that is more practical and safe that can replace the key of security safe box. In the research, the researcher uses the method of fingerprint and a PIN by designing a circuit input tool using the output fingerprint sensor and keypad. For the series of processor,the researcher applies the Arduino microcontroller Uno R3 while for series output the researcher applies three output circuit such as LCD, Buzzer, and Selenoids. Security tool safe box can only be operated by entering PIN and fingerprint which have been registered. Hence, the users do not need to save an object to operate the safe box. Based on the results of testing, this tool is able to open the safe box by inputting 5 registered ID interchangeably as much as 25 times. The Solenoids then are able to operate when they are given voltage > 9, 5V 350 mA to 12V 800 mA.
Possibilities of Legal Regulation of the Conservation of Sacred Places within the Cultural Landscape: The Case of the Republic of Kazakhstan
Authors: Mussatayeva Farida , Yermagambetova Kuralay , Shamakhay Saira , Baisarina Zhazira , Mustafina Tolganay 
Published: June 2024

In recent years, there has been growing attention to the preservation of sacred sites and understanding their significance within the cultural landscape of the Republic of Kazakhstan. This renewed interest is driven by a revival of national historical and cultural values. The study is relevant since sacred spaces affect the formation of objective historical memory, which is an important component of the national identity. This, in turn, contributes to the consolidation of the people and ensures the national security of the state. The article aims to propose measures (recommendations) to improve legal regulation and preserve the sacred places of the cultural landscape of Kazakhstan. To achieve these objectives, the authors employed methods of theoretical generalization, structural-logical analysis, and synthesis, as well as the method of expert survey. The paper identifies the main problems in the implementation of legal norms for the conservation of cultural landscapes and suggests potential solutions to overcome these challenges. It also outlines measures to increase public participation in the preservation of the cultural landscape. This study concludes that it is necessary to popularize knowledge about the specific features of sacred places in a particular region, develop a program for the preservation of the cultural landscape, and advise residents on the methods and means of preserving sacred places.
The Influence of Mass Media and Social Networks on the Spread of Slang
Authors: Ly Ngoc Toan  
Published: June 2024

This study investigates the influence of mass media and social networks on the proliferation of youth slang. The theoretical framework integrates Rogers' (2003) diffusion of innovations theory and Bandura's (1977) social learning theory. Rogers' theory elucidates how an innovation, such as youth slang, diffuses through a social system, shaped by factors like relative advantage, compatibility, complexity, trialability, and observability. Bandura's theory explains how individuals acquire and adopt new behaviors through observation and imitation, emphasizing the role of environmental and social factors. Employing a qualitative approach, data will be collected from television programs, films, and social media platforms where youth slang is prevalent. NVivo 14 qualitative data analysis software will analyze the collected data to identify patterns, themes, and underlying mechanisms driving slang diffusion. The findings aim to provide insights into how mass media and social networks facilitate the spread of youth slang through observational learning, social influence, and the diffusion of linguistic innovations. By integrating th ese theoretical perspectives, the study seeks to contribute to the understanding of slang propagation dynamics in the digital era, informing efforts to address language evolution and promote effective intergenerational communication. An evaluation of the research process and potential solutions for mitigating negative impacts will be included.
SOSIALISASI PENGGUNAAN DAN PERAWATAN MESIN PENCAIR SAMPAH PLASTIK DI KELURAHAN SAWAH LEBAR BARU KOTA BENGKULU
Authors: Julia Purnama Sari  , Surapati Alex , Adhadi Kurniawan  
Published: June 2024

Sampah plastik merupakan salah satu permasalahan yang sangat serius di lingkungan masyarakat. Pengolahan sampah plastik yang tidak dapat dikelola dengan baik oleh masyarakat dapat mengganggu lingkungan. Hal ini terjadi pula di Kelurahan Sawah Lebar Baru Kota Bengkulu. Di lingkungan Kelurahan Sawah Lebar Baru terdapat titik pembuangan sampah oleh masyarakat dan menumpuk di titik tersebut sehingga membuat lingkungan tersebut menjadi kotor dan tidak sehat. Perlu dilakukan upaya untuk mengatasi permasalahan tersebut. Salah satu caranya dengan teknologi dan pengetahuan dasar dalam mengolah sampah. Teknologi dan pengetahuan ini perlu diberikan kepada masyarakat agar dalam mengolah sampah dengan tepat menggunakan teknologi tersebut. Tujuan pengabdian ini adalah membangkitkan kesadaran masyarakat untuk dapat mengelola sampah dengan baik khususnya sampah plastik. Tahapan metode yang dilaksanakan adalah memberikan mesin pencair sampah plastik, melakukan sosialisasi dengan memberikan informasi terkait pengelolaan sampah plastik, praktik cara penggunaan mesin pencair sampah plastik menjadi paving blok dan perawatannya. Hasil dari kegiatan ini adalah meningkatnya kesadaran masyarakat terhadap kebersihan lingkungan, masyarakat mengetahui cara pengelolaan sampah plastik, timbulnya keinginan untuk mengelola sampah plastik menjadi paving blok sehingga menjadikannya sebagai ladang usaha bagi masyarakat di Kelurahan Sawah Lebar Baru, dan dengan sosialisasi ini tentunya dapat mengatasi permasalahan sampah plastik yang menumpuk di lingkungan Sawah Lebar Baru.

Kata kunci: Mesin Pencair Sampah Plastik, Sampah Plastik, Paving Blok, Kelurahan Sawah Lebar Baru
PENERAPAN METODE NAIVE BAYES UNTUK KLASIFIKASI KATEGORI OLAH PANGAN (STUDI KASUS DINAS KESEHATAN KOTA PALEMBANG)
Authors: Oktaviyani Ajeng , Heryati Agustina , Alie M. Fadhiel Alie 
Published: June 2024

Dinas kesehatan merupakan bagian integral dari struktur pemerintahan yang memiliki tanggung jawab luas untuk mengelola berbagai aspek kesehatan, aktivitas pelayanan medis sehari-hari juga berperan dalam menjaga keseimbangan gizi yang sehat, yang tercermin dari makanan olahan yang baik dan berkualitas. Oleh karena itu perlu adanya pengelompokan dan pengklasifikasian pada olahan pangan. Adapun permasalahan yang terdapat dalam penelitian ini yaitu adanya kesulitan yang dialami oleh Dinas Kesehatan Kota Palembang dalam menentukan klasifikasi produk olah pangan. Oleh karena itu, peneliti menggunakan metode Naive Bayes dan Software RapidMiner sebagai perangkat lunak pendukung dalam penelitian ini. Dalam penelitian ini, pada pengujian Accuracy di dapatkan hasil nilai yang sama antara perhitungan Rapidminer dan perhitungan manual Naive Bayes yaitu kelas positif 94,52%: Nabati, pada pengujian Precission terdapat perbedaan antara perhitungan RapidMiner dengan perhitungan Naive Bayes manual, pada perhitungan RapidMiner didapatkan hasil yang lebih besar yaitu 93,22% Kelas Positif: Nabati, sedangkan perhitungan Naive Bayes manual didapatkan nilai 78%. Nilai serupa juga diperoleh pada pengujian Recall dimana antara perhitungan Rapidminer dan perhitungan manual Naive Bayes, nilainya sama yaitu 100% Kelas positif: Nabati, pada pengujian F1 Score diperoleh nilai yang sama antara perhitungan Rapidminer dan perhitungan manual Naive Bayes yaitu 100%, dan pada pengujian Rapidminer Area Under The Curve (AUC) Hasil yang diperoleh adalah 0,973 (kelas positif: Nabati), dan tingginya akurasi kurva ROC/AUC memberikan kriteria “Excellent Clasification (klasifikasi yang sangat baik)”, sehingga penelitian ini nilai penggunaan bahan pangan nabati lebih mendominasi dibandingkan penggunaan bahan pangan hewani. Diharapkan hasil dari penelitian ini dapat membantu Dinas Kesehatan dalam mengklasifikasi kategori olah pangan.

Kata Kunci: Naive Bayes, Klasifikasi, Olah Pangan, Dinas Kesehatan Kota Palembang, Pengawasan Produk Pangan. Bahan Pangan, Hewani, Nabati.
Risk factors for cervical lymph node metastasis of papillary thyroid cancer in elderly patients aged 65 and older
Authors: Zhang Yu , Ji Xiaoyu , Yang Zhou , Wang Yu 
Published: June 2024

ObjectiveTo assess the risk factors of cervical lymph node metastasis in elderly patients aged 65 years and older diagnosed with papillary thyroid cancer (PTC).Design and methodIn this retrospective analysis, we included a total of 328 elderly patients aged 65 years and older diagnosed with PTC. We thoroughly examined clinical features from these patients. Utilizing univariate and multivariate logistic regression analyses, we aimed to identify factors contributing to the risk of central and lateral lymph node metastasis (CLNM/LLNM) in this specific population of PTC patients aged 65 years and older.ResultsIn the univariate analysis, CLNM was significantly associated with tumor size, multifocality, bilaterality, and microcalcification, while only tumor size ≥ 1cm (OR = 0.530, P = 0.019, 95% CI = 0.311 – 0.900) and multifocality (OR = 0.291, P &lt; 0.001, 95% CI = 0.148 - 0.574) remained as risk factors in the multivariate analysis. LLNM was confirmed to be associated with male (OR = 0.454, P &lt; 0.020, 95% CI = 0.233 - 0.884), tumor size ≥ 1cm (OR = 0.471, P = 0.030, 95% CI = 0.239 – 0.928), age ≥ 70 (OR = 0.489, P = 0.032, 95% CI = 0.254 – 0.941), and microcalcification (OR = 0.384, P = 0.008, 95% CI = 0.189 – 0.781) in the multivariate analysis. In elderly PTC patients with CLNM, male gender (OR = 0.350, P = 0.021, 95% CI = 0.143 – 0.855), age ≥ 70 (OR = 0.339, P = 0.015, 95% CI = 0.142 – 0.810), and bilaterality (OR = 0.320, P = 0.012, 95% CI = 0.131 – 0.779) were closely associated with concomitant LLNM in both univariate and multivariate analyses.ConclusionFor elderly PTC patients aged 65 and older, tumor size ≥ 1cm and multifocality are significant risk factors for CLNM. Meanwhile, male, tumor size ≥ 1cm, age ≥ 70, and microcalcification are crucial predictors for LLNM. In patients already diagnosed with CLNM, male, age ≥ 70, and bilaterality increase the risk of LLNM.
Knowing the lay of the land: changes to land use and cover and landscape pattern in village tank cascade systems of Sri Lanka
Authors: Ratnayake Sujith S. , Reid Michael , Larder Nicolette , Hunter Danny , Ranagalage Manjula , Kogo Benjamin , Dharmasena Punchi B. , Kariyawasam Champika S. 
Published: June 2024

Social-ecological systems (SESs) possess a great diversity of land use and land cover (LULC) types with unique assemblages of biodiversity and ecosystem services. However, LULC changes due to landscape fragmentation are emerging as major threats to the system productivity of SESs around the world. This study examined changes to LULC extent and landscape patterns in the Village Tank Cascade Systems (VTCSs) of Sri Lanka using satellite imagery and GIS techniques between 1994 and 2021. Multispectral Landsat images (5 TM and 8 OLI/TIRS) obtained from Google Earth Engine were classified using machine learning algorithms. Overall accuracies obtained were 85.9% (1994) and 88.6% (2021). The LULC change matrix and spatial pattern metrics were used to examine LULC and landscape pattern change dynamics over the VTCS landscapes. LULC change matrix results revealed that forest, which is the dominant LULC class covering 73.7% of the total land area was reduced by 206,725 ha due to transformation into agricultural (70.43%) and scrub (24.33%) lands between 1994 and 2021. Over this time landscape pattern of the VTCS has gradually changed from forest to agricultural land-dominated landscape, with forest and agricultural land types showing a significant negative correlation (p &lt; 0.001; R2 &gt; 0.868), particularly in the southeastern region. Landscape patterns were analysed based on eight spatial metrics calculated at both the landscape and class levels using FRAGSTATS spatial pattern analysis software. At the landscape level, the structure became more dispersed and complex in shape. Heterogeneity was noted to have gradually increased with weakening connectivity, whereas the fragmentation process had gradually accelerated. At the class level, the dominance of forest patches decreased, fragmentation and isolation increased, and connectivity and shape complexity reduced leading to the loss of fragmented forest habitats. The number of patches within the agricultural class increased and became more aggregated and complex in shape. Landscape performance indicators show that VTCSs have experienced a gradual loss of environmental sustainability. Assessment of LULC along with fragmentation can help to monitor the spatial pattern impacts that determine ecological integrity. Thus, the study provides scientific guidance for ecological restoration in degraded VTCSs to effectively improve ecological productivity.
N6-methyladenosine methylation analysis of circRNAs in acquired middle ear cholesteatoma
Authors: He Jun , Mahmoudi Ahmad , Yao Jacqueline , Yuan Qiulin , Fu Jinfeng , Liu Wei 
Published: June 2024

IntroductionMiddle ear cholesteatoma is a chronic middle ear disease characterized by severe hearing loss and adjacent bone erosion, resulting in numerous complications. This study sought to identify pathways involved in N6-methyladenosine (m6A) modification of circRNA in middle ear cholesteatoma.MethodsA m6A circRNA epitranscriptomic microarray analysis was performed in middle ear cholesteatoma tissues (n = 5) and normal post-auricular skin samples (n = 5). Bioinformatics analyses subsequently explored the biological functions (Gene Ontology, GO) and signaling pathways (Kyoto Encyclopedia of Genes and Genomes, KEGG) underlying middle ear cholesteatoma pathogenesis. Methylated RNA immunoprecipitation qPCR (MeRIP-qPCR) was performed to verify the presence of circRNAs with m6A modifications in middle ear cholesteatoma and normal skin samples.ResultsMicroarray analysis identified 3,755 circRNAs as significantly differentially modified by m6A methylation in middle ear cholesteatoma compared with the normal post-auricular skin. Among these, 3,742 were hypermethylated (FC ≥ 2, FDR &lt; 0.05) and 13 were hypomethylated (FC ≤ 1/2, FDR &lt; 0.05). GO analysis terms with the highest enrichment score were localization, cytoplasm, and ATP-dependent activity for biological processes, cellular components, and molecular functions respectively. Of the eight hypermethylated circRNA pathways, RNA degradation pathway has the highest enrichment score. Peroxisome Proliferator-Activated Receptor (PPAR) signaling pathway was hypomethylated. To validate the microarray analysis, we conducted MeRIP-qPCR to assess the methylation levels of five specific m6A-modified circRNAs: hsa_circRNA_061554, hsa_circRNA_001454, hsa_circRNA_031526, hsa_circRNA_100833, and hsa_circRNA_022382. The validation was highly consistent with the findings from the microarray analysis.ConclusionOur study firstly presents m6A modification patterns of circRNAs in middle ear cholesteatoma. This finding suggests a direction for circRNA m6A modification research in the etiology of cholesteatoma and provides potential therapeutic targets for the treatment of middle ear cholesteatoma.
Circulating immune and plasma biomarkers of time to HIV rebound in HIV controllers treated with vesatolimod
Authors: Abdel-Mohsen Mohamed , Deeks Steven , Giron Leila , Hong Kai Ying , Goldman Aaron , Zhang Liao , Huang Susie S. Y. , Verrill Donovan , Guo Susan , Selzer Lisa , de Vries Christiaan R. , Vendrame Elena , SenGupta Devi , Wallin Jeffrey J. , Cai Yanhui 
Published: June 2024

BackgroundAntiretroviral therapy (ART) for HIV-1 treatment has improved lifespan but requires lifelong adherence for people living with HIV (PLWH), highlighting the need for a cure. Evaluation of potential cure strategies requires analytic treatment interruption (ATI) with close monitoring of viral rebound. Predictive biomarkers for HIV-1 rebound and/or duration of control during ATI will facilitate these HIV cure trials while minimizing risks. Available evidence suggests that host immune, glycomic, lipid, and metabolic markers of inflammation may be associated with HIV-1 persistence in PLWH who are treated during chronic HIV-1 infection.MethodsWe conducted post-hoc analysis of HIV controllers who could maintain low levels of plasma HIV-1 without ART in a phase 1b vesatolimod trial. Baseline and pre-ATI levels of immune, glycomic, lipidomic, and metabolomic markers were tested for association with ATI outcomes (time of HIV-1 rebound to 200 copies/mL and 1,000 copies/mL, duration of HIV-1 RNA ≤400 copies/mL and change in intact proviral HIV-1 DNA during ATI) using Spearman’s correlation and Cox proportional hazards model.ResultsHigher levels of CD69+CD8+ T-cells were consistently associated with shorter time to HIV-1 rebound at baseline and pre-ATI. With few exceptions, baseline fucosylated, non-galactosylated, non-sialylated, bisecting IgG N-glycans were associated with shorter time to HIV rebound and duration of control as with previous studies. Baseline plasma MPA and HPA binding glycans and non-galactosylated/non-sialylated glycans were associated with longer time to HIV rebound, while baseline multiply-galactosylated glycans and sialylated glycans, GNA-binding glycans, NPA-binding glycans, WGA-binding glycans, and bisecting GlcNAc glycans were associated with shorter time to HIV rebound and duration of control. Fourteen bioactive lipids had significant baseline associations with longer time to rebound and duration of control, and larger intact proviral HIV-1 DNA changes; additionally, three baseline bioactive lipids were associated with shorter time to first rebound and duration of control.ConclusionConsistent with studies in HIV non-controllers, proinflammatory glycans, lipids, and metabolites were generally associated with shorter duration of HIV-1 control. Notable differences were observed between HIV controllers vs. non-controllers in some specific markers. For the first time, exploratory biomarkers of ATI viral outcomes in HIV-controllers were investigated but require further validation.
Decoding immune-related gene-signatures in colorectal neoplasia
Authors: Omran Thura Akrem , Tunsjø Hege Smith , Jahanlu David , Brackmann Stephan Andreas , Bemanian Vahid , Sæther Per Christian 
Published: June 2024

BackgroundColorectal cancer (CRC) is a significant health issue, with notable incidence rates in Norway. The immune response plays a dual role in CRC, offering both protective effects and promoting tumor growth. This research aims to provide a detailed screening of immune-related genes and identify specific genes in CRC and adenomatous polyps within the Norwegian population, potentially serving as detection biomarkers.MethodsThe study involved 69 patients (228 biopsies) undergoing colonoscopy, divided into CRC, adenomatous polyps, and control groups. We examined the expression of 579 immune genes through nCounter analysis emphasizing differential expression in tumor versus adjacent non-tumorous tissue and performed quantitative reverse transcription polymerase chain reaction (RT-qPCR) across patient categories.ResultsKey findings include the elevated expression of CXCL1, CXCL2, IL1B, IL6, CXCL8 (IL8), PTGS2, and SPP1 in CRC tissues. Additionally, CXCL1, CXCL2, IL6, CXCL8, and PTGS2 showed significant expression changes in adenomatous polyps, suggesting their early involvement in carcinogenesis.ConclusionsThis study uncovers a distinctive immunological signature in colorectal neoplasia among Norwegians, highlighting CXCL1, CXCL2, IL1B, IL6, CXCL8, PTGS2, and SPP1 as potential CRC biomarkers. These findings warrant further research to confirm their role and explore their utility in non-invasive screening strategies.