bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of Ecto-Parasitic Fauna in Silver Catfish (Bagrusbajad) from Zobe Reservoir, Katsina State
Authors: Bako Hadiza , Sadauki M. A. , Maikudi A. A. 
Published: May 2024

Fish parasitic infections inflict a most importanteconomic concern on fish farming industries. Helminthic infestations can cause a variety of fitness difficulties as well as economic sufferings for fishing populations. Prevalence of ecto-parasites fauna in silver catfish Bagrusbayad from Zobe reservoir, Katsina Nigeriawas inspected to comprehend the healthiness conditionof the fish, possibledanger to their existence as well asprotection of consumption of fish from the water body.The current study was undertaken between August and October, 2023 to determine the prevalence of fish ecto-parasites of Bagrusbajad and the associated risk factors in Zobereservoir Dutsin-Ma, Katsina State, Nigeria. A total number of108 fish samples were collected and examined from Zobe reservoir. The fish was identified as well as separated based on their sex before being transferred live to the Fish Biology laboratory, Federal University Dutsin-Ma, Katsina State for additional evaluation. Out of 108 fish samples from Zobe, 88 were male and 20 were female. Fish parasites recovered and their prevalence among Bagrusbajad obtained from Zobe reservoir includes; Tricodinaspp 17 (68%), and Gyrodactylusspp 8 (32%). The prevalence of parasites recovered from the fish species in this study was low. In conclusion, Bagrusbajad from Zobe reservoir were infected by parasites that are of economic importance. The findings suggest that the observed parasitic infections may adversely affect Bagrusbajad and if not well managed, could also infect human beings who consume the fish. It is therefore recommended that communities along the reservoir should desist from activities likely to increase parasite load, also, the part organs of harvested fishes from the study area should be discarded rather than consume to prevent zoonotic diseases.
Cuando hacer partícipe a la población de decisiones a la hora de una intervención en el patrimonio histórico
Authors: Lorenzo Maestre Rocío 
Published: May 2024

Han habido intervenciones de conservación y restauración que han supuesto un gran cambio para las piezas como las limpiezas o retiradas de re-policromías, que han sido sometidas a juicio público una vez terminados los tratamientos, que a lo mejor se podrían haber evitado con una consulta a las personas o colectivos a los que pertenece el bien cultural.

Es imprescindible hacernos varias preguntas, qué riesgos tiene el bien y cuales son las intervenciones que haríamos si adoptamos un criterio de mínima intervención; y de quien es y dónde está el bien.

Y desde aquí plantearnos si la intervención tendría que ser dialogada o sometida a votación, siempre teniendo en cuenta nuestro criterio como profesionales de la conservación del patrimonio y por ende a las leyes y criterios que adoptamos de una manera deontológica.
SANKSI ADAT BAGI PANYAPA DALAM HUKUM ADAT DAYAK NGAJU
Authors: Pratiwi Putri Fransiska Purnama , Pratama Aji 
Published: May 2024

Panyapa tidak memiliki istilah atau pengertian khusus dalam Hukum Adat Dayak Ngaju maupun dalam 96 Pasal Perjanjian Tumbang Anoi 1894, namun seseorang yang sering kali memaki orang lain dan membuat tersinggung perasaan orang lain dikenal dengan sebutan Panyapa oleh masyarakat adat setempat. Penelitian ini bertujuan untuk mengetahui prosedur pemberian sanksi adat Dayak Ngaju bagi Panyapa dan upaya memberikan efek jera bagi panyapa dalam Hukum Adat Dayak Ngaju. Dari hasil penelitian prosedur penyelesaian dilakukan di tingkat kelurahan terlebih dahulu oleh Mantir Adat lalu dibawa ketingkat kecamatan yang di selesaikan oleh Damang Kepala Adat. Upaya Damang Kepala Adat Dalam Memberikan Efek Jera Bagi Panyapa di Wilayah Kecamatan Kahayan Hilir Kabupaten Pulang Pisau dengan cara melibatkan dan disaksikan oleh perwakilan masyarakat setempat dalam penerapan sanksi adat sehingga memberikan sanksi moral pada pelaku untuk tidak mengulangi lagi dan masyarakat bisa belajar untuk tidak mencontoh perbuatan tersebut.
Transformasi Digital dan Strategi Ketahanan Pasca Pandemi pada UMKM di Kota Banjarmasin
Authors: Wulandari Dyah Sri , Prasetya Muhammad Riko Anshori 
Published: May 2024

Penelitian ini bertujuan untuk mengetahui efektifitas transformasi digital terhadap omset penjualan antara UMKM yang telah menerapkan pemasaran digital dengan UMKM yang masih menggunakan pemasaran tradisional, serta mengetahui strategi ketahanan pada masa pandemi dan pasca pandemi. Menggunakan metode kualitatif deskriptif dengan sumber data sekunder dan primer serta dianalisis menggunakan analisis SWOT, lokasi penelitian di Kota Banjarmasin. Hasilnya Transformasi Digital efektif terhadap peningkatan omset penjualan dan dapat menjadi kekuatan UMKM untuk mengembangkan usahanya, untuk UMKM yang masih menerapkan pemasaran secara tradisional maka diharapkan terus berupaya mengatasi berbagai kendala yang dihadapi dalam betransformasi ke pemasaran digital demi berkembangnya usaha yang dijalankan. Untuk strategi ketahanan strategi yang digunakan adalah strategi Kekuatan dan Peluang SO (Strength-Opportunity) untuk dapat bertahan baik dalam masa pandemi maupun pasca pandemi, strategi SO yang dirumuskan adalah mengoptimalkan penggunaan market place, sosial media, Flatfrom digital dan lain sebagainya dalam pemasaran produk, berinovasi agar produk yang ditawarkan mampu bersaing, dan dukungan Pemerintah Kota Banjarmasin agar dapat membantu UMKM dalam kemudahan informasi mengenai izin usaha, perizinan ekspor-impor, P-IRT, sertifikasi produk halal, serta kemudahan mendapatkan bahan baku. Kebaruan pada penelitian ini adalah mengenai transformasi digital dengan menambah strategi kemampuan bertahan pada dua situasi yaitu saat pandemi dan pasca pandemi, dengan dibuatnya 2 situasi tersebut sehingga dapat menambah referensi para UMKM dalam menentuakan strategi yang tepat sesuai situasi dan objek penelitian dikhususkan untuk UMKM yang bergerak pada usaha kuliner atau makanan.
Efektivitas Peran Yayasan Adaro Bangun Negeri (YABN) Pada Program Corporate Social Responsibility (CSR) Adaro Group dalam Meningkatkan Citra Perusahaan Di Kabupaten Tabalong
Authors: Warni Warni Warni 
Published: May 2024

Program Tanggung jawab suatu perusahaan dapat dilihat dari komitmen perusahaan yang berperan serta membangun ekonomi yang berkelanjutan melalui program CSR. Adaro Foundation merupakan salah satu pilar untuk mengkoordinasikan program-program Tanggung Jawab Sosial Perusahaan Grup Adaro melalui Yayasan Adaro Bangun Negeri. Grup Adaro terus berkontribusi dengan melaksanakan tanggung jawab sosialnya yang disebut “Adaro Nyalakan Perubahan” terhadap masyarakat. Salah satu kegiatan CSR Adaro Group melalui YABN yaitu Program Adaro Santri Sejahtera (PASS). Tujuan penelitian yaitu untuk mengetahui efektivitas peran YABN pada program CSR Adaro Group dalam meningkatkan citra perusahaan Di Kabupaten Tabalong. Metode yang digunakan dalam penelitian ini adalah metode penelitian kualitatif dengan pendekatan inkuiri naratif dan bersifat deskriptif. Hasil menunjukkan bahwa Program CSR yang dilakukan oleh YABN telah dilaksanakan dengan baik dan efektif. Program CSR yang dilakukan YABN saat ini meningkat menjadi pengawasan seluruh kegiatan CSR Adaro Group. Peran YABN pada program PASS sangat memahami akan kebutuhan pokok di 3 Ponpes binaan dengan fokus bantuan pada 3 bidang usaha. Bantuan yang disalurkan yaitu berbentuk dana maupun barang dan disalurkan tanpa mengharapkan timbal balik dari dana yang diberikan. Kesimpulan yaitu Program CSR Adaro Group pada Program PASS yang dijalankan oleh YABN, mampu memberikan manfaat besar kepada penerima CSR yang berfokus pada pemberdayaan Ponpes dan masyarakat sekitar, khususnya untuk efektivitas kegiatan yang diberikan YABN dapat meningkatkan citra perusahaan baik dari aspek ekonomi maupun aspek lainnya.
Unraveling genetic causality between metformin and myocardial infarction on the basis of Mendelian randomization
Authors: Zhuang Yongru , Pan Xiaojun , Chen Ya , Song Jinfang 
Published: May 2024

BackgroundIn recent years, several studies have explored the effect of metformin on myocardial infarction (MI), but whether metformin has an improvement effect in patients with MI is controversial. This study was aimed to investigate the causal relationship between metformin and MI using Mendelian randomization (MR) analysis.MethodsThe genome-wide significant (P&lt;5×10-8) single-nucleotide polymorphisms (SNPs) in patients with metformin and patients with MI were screened from the Open genome-wide association study (GWAS) project as instrumental variables (IVs). The study outcomes mainly included MI, old MI, acute MI, acute transmural MI of inferior wall, and acute transmural MI of anterior wall. The inverse variance weighted (IVW) method was applied to assess the main causal effect, and weighted median, simple mode, weighted mode methods, and MR-Egger regression were auxiliary applied for supplementary proof. The causal relationship between metformin and MI was assessed using odds ratios (OR) and 95% confidence intervals (95% CI). A leave-one-out method was used to explore the effect of individual SNPs on the results of IVW analyses, and a funnel plot was used to analyze the potential bias of the study results, thus ensuring the robustness of the results.ResultsIn total, 16, 84, 39, 26, and 34 SNPs were selected as IVs to assess the genetic association between metformin and outcomes of MI, old MI, acute MI, acute transmural MI of inferior wall, and acute transmural MI of anterior wall, respectively. Treatment with metformin does not affect the risk of acute transmural MI of anterior wall at the genetic level (P&gt;0.05; OR for inverse variance weighted was 1.010). In the cases of MI, old MI, acute MI, and acute transmural MI of inferior wall, metformin may even be a risk factor for patients (P&lt;0.05; ORs for inverse variance weighted were 1.078, 1.026, 1.022 and 1.018 respectively). There was no horizontal pleiotropy or heterogeneity among IVs. The results were stable when removing the SNPs one by one.ConclusionMetformin is not protective against the risk of myocardial infarction in patients and may even be a risk factor for MI, old MI, acute MI, and acute transmural MI of inferior wall.
The correlation between autumnal landscape colors and environmental factors and the analysis of ecological service functions in subtropical urban scenic forests
Authors: Wang Zi , Li Mingyang 
Published: May 2024

Background and objectivesUrban scenic forests are a main component of forest parks, and a quantitative study of the landscape color of urban scenic forests can provide a scientific reference for the planning of forest parks and the design of scenic forest management measures. The purpose of the study is to find the quantitative correlation between autumn landscape color and ecological service functions and to obtain the important influencing factors.Materials and methodsThis study focuses on Purple Mountain National Forest Park in Nanjing as a case study area and uses forest resource survey data from Purple Mountain National Forest Park in 2020, autumn landscape color photograph data from Purple Mountain National Forest Park in 2020, and digital elevation model data as the main information sources. The correlation between two ecological functions of above-ground biomass (AGB), tree species diversity (TSD), and influencing factors (including color factors, stand factors, and terrain factors) were both analyzed by Pearson correlation analysis. Then, multiple linear regression (MLR) and random forest (RF) methods were used to perform the quantitative relationship between the functions.ResultsThe results show that, in the established quantitative models of AGB, with TSD as the dependent variable, the correlation coefficients of the MLR model are both above 0.784, while the correlation coefficients of the RF model are all above 0.872. Moreover, the brightness value of the main color (BRI), the number of yellow-green blocks (NYG), and the number of yellow blocks (NY) have important effects on the two ecological service functions.ConclusionIn conclusion, there are complex non-linear relationships between the ecological service functions of AGB, TSD, and influencing factors, and the landscape color can reflect the ecological function of the scenic forest to some extent. In addition, stand factors and color factors have important effects on the ecological function of AGB. Color factors and terrain factors have important effects on the ecological function of TSD. BRI, NYG, and NY have important effects on the two ecological functions. Finally, this quantitative method has universal applicability in the temperate zone, warm temperate zone, and subtropical zone of China.
Preclinical characterization of a novel investigational monoclonal antibody CM313 with potent CD38-positive cell killing activity
Authors: Liu Wei , Yu Juntao , Sun Kaiwen , Song Qin , Li Yuling , He Yanyun , Wang Yanrong , Xu Gang , Wang Changyu , Chen Bo 
Published: May 2024

IntroductionCM313 is currently under clinical investigation for treatments of multiple myeloma, systemic lupus erythematosus, and immune thrombocytopenia. We aimed to report the preclinical profile of the novel therapeutic anti-CD38 monoclonal antibody (mAb) CM313, with an emphasis on the difference with other CD38-targeting mAb.MethodsThe binding of CM313 to CD38 recombinant protein across species was assessed using ELISA. The binding of CM313 to CD38-positive (CD38+) cells was detected using flow cytometry assays. CM313-induced complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP) and apoptosis on different CD38+ cells were assessed by LDH release assays or flow cytometry assays. The effect of CM313 on CD38 enzymatic activity was measured using fluorescence spectroscopy. CM313 immunotoxicity in human blood was assessed using flow cytometry assays, ELISA, and LDH release assays. Anti-tumor activity of CM313 was assessed in multiple mouse xenograft models. Safety profile of CM313 were evaluated in cynomolgus monkeys and human CD38 transgenic (B-hCD38) mice.ResultsThere exist unique sequences at complementarity-determining regions (CDR) of CM313, which facilitates its affinity to CD38 is consistently higher across a spectrum of CD38+ cell lines than daratumumab. In vitro studies showed that CM313 induces comparable killing activity than daratumumab, including ADCC, CDC, ADCP, apoptosis induced by Fc-mediated cross-linking, and effectively inhibited the enzymatic activity of CD38. However, CM313 showed more potent CDC than isatuximab. In vivo, CM313 dose-dependently inhibited xenograft tumor growth, both as a monotherapy and in combination with dexamethasone or lenalidomide. Furthermore, CM313 was well tolerated with no drug-related clinical signs or off-target risks, as evidenced by 4-week repeat-dose toxicology studies in cynomolgus monkeys and B-hCD38 mice, with the later study showing no observed adverse effect level (NOAEL) of 300mg/kg once weekly.DiscussionCM313 is a novel investigational humanized mAb with a distinct CDR sequence, showing comparable killing effects with daratumumab and stronger CDC activity than isatuximab, which supports its clinical development.
Isotopic niches reveal the trophic structure of the cetacean community in the oceanic waters around the Azores
Authors: Lebon Myriam , Colaço Ana , Prieto Rui , Cascão Irma , Oliveira Cláudia , Tobeña Marta , Planque Yann , Spitz Jérôme , Silva Mónica A. 
Published: May 2024

IntroductionThe oceanic waters around the Azores host a high diversity of cetaceans, with 28 species of toothed and baleen whales present year-round or seasonally. This high cetacean biodiversity likely plays an important role in the structure, functioning and productivity of the ecosystem, and may increase trophic redundancy, thus contributing to food web resilience to disturbances.MethodsHere we used stable isotope (δ13C and δ15N) analysis to characterize trophic niches, assess niche overlap, describe the trophic structure and discuss potential redundancy in the cetacean community. Using 407 samples from 12 species, we estimated Standard Ellipse Areas and overlaps between species and used a hierarchical clustering analysis to identify trophic guilds.Results and discussionδ13C and δ15N values ranged from -20.53 to -15.46‰ and from 7.78 to 14.41‰ respectively, suggesting the use of diverse habitats and resources among cetacean species. Clustering analysis revealed that species were grouped into four trophic guilds, segregated mainly by trophic position (TP): a low-TP guild with three zooplanktivore baleen whales, a mid-TP guild with micronektivores, a high-TP guild with micronekton and nekton consumers, and a cluster with only Pseudorca crassidens. There was significant isotopic niche overlap between one pair of species within each guild, indicating some potential for trophic redundancy in the community. Yet, these pairs also showed some form of spatial or temporal partitioning, suggesting that mechanisms promoting species coexistence could play a key role in structuring the cetacean community in the region and in its ecological role.
Hemodynamic effects of withholding vs. continuing angiotensin II receptor blockers on the day of prone positioning spinal surgery in elderly patients
Authors: Yuan Ruimei , Xu Min , Hu Chunhai , Ma Huailing , Meng Fanjun , Ren Jie , Wen Jing 
Published: May 2024

IntroductionThe hemodynamic effects of withholding vs. continuing angiotensin II receptor blockers (ARBs) before surgery in elderly patients undergoing spinal surgery in a prone position during anesthesia induction to skin incision are still unknown.MethodsIn this prospective study, 80 patients undergoing spinal surgery in a prone position with general anesthesia, aged 60–79 years, American Society of Anesthesiologists (ASA) II or III, were enrolled. Patients who had ARBs only in their preoperative medication list were randomly divided into two groups at a 1:1 ratio: In Group A, ARBs were continued on the morning of surgery, while in Group B, they were withhold. Norepinephrine was infused to maintain the blood pressure at the baseline level of ±20% during anesthesia induction in all patients. The primary outcome was the consumption of norepinephrine in each group from anesthesia induction to skin incision. The secondary outcomes include changes in invasive arterial blood pressure and heart rate, the fluid infusion volumes, the amounts of anesthetic drugs, and the total time from induction to skin incision.ResultsThere were no significant differences in the demographics, the fluid infusion volumes, the amounts of anesthetic drugs, the total time from induction to skin incision, and hemodynamics at different time points (p &gt; 0.05), while significant differences were found in norepinephrine consumption between the two groups (p &lt; 0.001). Compared with Group B, the consumption of norepinephrine increased significantly in Group A (93.3 ± 29.8 vs. 124.1 ± 38.7 μg, p = 0.000). In addition, the same trend was illustrated in the pumping rate of norepinephrine between Group B (0.04 ± 0.01 μg·kg−1·min−1) and Group A (0.06 ± 0.02 μg·kg−1·min−1) (p = 0.004).ConclusionOur study conducted in elderly patients with hypotension undergoing prone spinal surgery demonstrated a greater pumping rate of norepinephrine during anesthesia induction in patients with ARBs continuing before surgery than those withholding, indicating that it was more difficult to maintain hemodynamic stability.Clinical Trial Registration: https://www.chictr.org.cn/showproj.html?proj=141081, ChiCTR2100053583.
Immune cells mediated the causal relationship between the gut microbiota and lung cancer: a Mendelian randomization study
Authors: Chen Zhiting , Wang Zhe , Ma Hao , Bao Hejing , Jiang Ting , Yang Ting , Ma Shudong 
Published: May 2024

IntroductionThe gut microbiota (GM) influences the occurrence and progression of lung cancer (LC), with potential involvement of immune cells (IC). We aimed to investigate the causal impact of GM on LC and identify potential immune cell mediators.MethodsThe utilized data for the Genome-Wide Association Studies (GWAS) were summarized as follows: gut microbiota data from the Dutch Microbiome Project (DMP) (N = 7,738), lung cancer data from the Transdisciplinary Research in Cancer of the Lung (TRICL) and International Lung Cancer Consortium (ILCCO) (Ncase = 29,266, Ncontrol = 56,450) included four types of cancer: NSCLC, LUAD, LUSC, and SCLC, and immune cell data from European populations (N = 3,757). We employed bi-directional two-sample univariable Mendelian randomization (UVMR), multivariable Mendelian randomization (MVMR), and mediation analysis to assess the causal relationship between GM and LC and potential immune cell mediators.ResultsBi-directional UVMR analysis revealed that 24 gut microbiota species can affect LC, while LC can affect the abundance of 17 gut microbiota species. Mediation analysis demonstrated that six immune cells mediated the causal relationships of seven gut microbiota species on LC: “CCR7 on naive CD8+ T cell” mediated the causal relationship between s_Alistipes_putredinis and LUAD, with a mediation proportion of 9.5% and P = 0.018; “IgD− CD27− B cell %lymphocyte” mediated the causal relationships between g_Gordonibacter and s_Gordonibacter_pamelaeae with LUSC, with mediation proportions of 11.8% and 11.9%, respectively and P = 0.029; “CD20− CD38− B cell %lymphocyte” mediated the causal relationship between s_Bacteroides_clarus and SCLC, with a mediation proportion of 13.8% and P = 0.005; “CD20 on IgD+ CD38− unswitched memory B cell” mediated the causal relationship between s_Streptococcus_thermophilus and SCLC, with a mediation proportion of 14.1% and P = 0.023; “HLA DR on CD14− CD16+ monocyte” mediated the causal relationship between s_Bifidobacterium_bifidum and SCLC, with a mediation proportion of 8.7% and P = 0.012; “CD45 on Granulocytic Myeloid-Derived Suppressor Cells” mediated the causal relationship between f_Lactobacillaceae and SCLC, with a mediation proportion of 4.0% and P = 0.021.ConclusionThis Mendelian randomization study identified several specific gut microbiotas that exhibit causal relationships with lung cancer and potentially mediate immune cells.