bluuebunny/crossref_metadata_2025_split huggingface dataset:
Views of young people with depression about family and significant other support: Interpretative phenomenological analysis study
Authors: McCann Terence V. , Lubman Dan I. , Clark Eileen 
Published: May 2012

ABSTRACTFamilies and significant others have an important role in helping young people cope with depression, but lack of support undermines coping. In this paper, we present the views of young people with depression about the role of family and significant others in assisting them to cope with their illness. An interpretative phenomenological analysis study was undertaken using semistructured, audio‐recorded interviews with 26 young people diagnosed with depression. The findings present two contrasting themes in the data, which reflect the young people's views about the influence of families and significant others in helping them cope with depression. The first, being supportive, highlighted how families and significant others helped through patience, tolerance, understanding, and encouragement; all of which strengthened young people's resilience as they attempted to cope with depression. The second theme, being unsupportive, showed how, in the young people's view, family conflict and change, and living in an unsupportive environment, compromised their ability to cope with depression. The findings suggest that mental health nurses, other clinicians, and primary care practitioners need to increase families' and significant others' understandings of depression and their capacity to support young people in these circumstances.
Potentiation of the P2X3 ATP receptor by PAR‐2 in rat dorsal root ganglia neurons, through protein kinase‐dependent mechanisms, contributes to inflammatory pain
Authors: Wang Shenglan , Dai Yi , Kobayashi Kimiko , Zhu Wanjun , Kogure Yoko , Yamanaka Hiroki , Wan You , Zhang Wensheng , Noguchi Koichi 
Published: May 2012

AbstractProinflammatory agents trypsin and mast cell tryptase cleave and activate protease‐activated receptor‐2 (PAR‐2), which is expressed on sensory nerves and causes neurogenic inflammation. P2X3 is a subtype of the ionotropic receptors for adenosine 5′‐triphosphate (ATP), and is mainly localized on nociceptors. Here, we show that a functional interaction of the PAR‐2 and P2X3 in primary sensory neurons could contribute to inflammatory pain. PAR‐2 activation increased the P2X3 currents evoked by α, β, methylene ATP in dorsal root ganglia (DRG) neurons. Application of inhibitors of either protein kinase C (PKC) or protein kinase A (PKA) suppressed this potentiation. Consistent with this, a PKC or PKA activator mimicked the PAR‐2‐mediated potentiation of P2X3 currents. In the in vitro phosphorylation experiments, application of a PAR‐2 agonist failed to establish phosphorylation of the P2X3 either on the serine or the threonine site. In contrast, application of a PAR‐2 agonist induced trafficking of the P2X3 from the cytoplasm to the plasma membrane. These findings indicate that PAR‐2 agonists may potentiate the P2X3, and the mechanism of this potentiation is likely to be a result of translocation, but not phosphorylation. The functional interaction between P2X3 and PAR‐2 was also confirmed by detection of the α, β, methylene‐ATP‐evoked extracellular signal‐regulated kinases (ERK) activation, a marker of neuronal signal transduction in DRG neurons, and pain behavior. These results demonstrate a functional interaction of the protease signal with the ATP signal, and a novel mechanism through which protease released in response to tissue inflammation might trigger the sensation to pain through P2X3 activation.
Transcriptomic analysis of responses to exudates reveal genes required for rhizosphere competence of the endophyte Azoarcus sp. strain BH72
Authors: Shidore Teja , Dinse Theresa , Öhrlein Johannes , Becker Anke , Reinhold‐Hurek Barbara 
Published: May 2012

SummaryEndophytic colonization is a very complex process which is not yet completely understood. Molecules exuded by the plants may act as signals which influence the ability of the microbe to colonize the host or survive in the rhizosphere. Here we used the whole genome microarray approach to investigate the response of the diazotrophic model endophyte, Azoarcus sp. strain BH72, to exudates of O. sativa cv. Nipponbare in order to identify differentially regulated genes. On exposure to exudates, an overall expression of 4.4% of the 3992 protein coding genes of Azoarcus sp. strain BH72 was altered, out of which 2.4% was upregulated and 2.0% was downregulated. Genes with modulated expression included a few whose involvement in plant–microbe interaction had already been established, whereas a large fraction comprised of genes encoding proteins with putative or unknown functions. Mutational analysis of several differentially regulated genes like those encoding a minor pilin PilX, signal transduction proteins containing GGDEF domains and a serine–threonine kinase as a putative component of the type IV secretion system (T6SS), revealed their role in host colonization. Our data suggest that strain BH72 may be primed for the endophytic lifestyle by exudates, as the expression of bacterial genes relevant for endophytic colonization of roots is induced by root exudates.
Normal science and paradigmatic shifts: political and regulatory strategies to develop investor protection in the aftermath of crisis
Authors: O’Brien Justin 
Published: May 2012

AbstractThe scale of the Global Financial Crisis prompted initial systematic reflection by leading politicians from Anglo‐Saxon countries. One commonality linked the analyses put forward by Gordon Brown (UK), Barack Obama (USA) and Kevin Rudd (Australia): the crisis had roots in ethical failure. The interlinked failure of structure and agency necessitated fundamental change in the theory and practice of the regulation of capital markets. The international regulatory reform agenda has, however, focused on the technical requirements of the former and largely ignored the latter. The paper argues that this is not only a mistake. It reflects the ongoing strength of the financial services industry to determine the ideational, ideological and institutional battleground.
FOLLOWING AT A DISTANCE (AGAIN): GENDER, EQUALITY, AND FREEDOM IN KARL BARTH'S THEOLOGICAL ANTHROPOLOGY
Authors: SPRINGS JASON A. 
Published: May 2012

AbstractThis article explores the possibility of moving beyond the apparent incapacity of Karl Barth's theological anthropology to accommodate gender equality. Barth's theological anthropology is read by critics and appreciative readers alike as confining the basic form of humanity to a binary opposition (I and Thou) from which he then derives a gender‐specific, hierarchical account of man and woman, and finally, of husband and wife as a paradigmatic ethical relationship. I first forward a close reading of Barth's account of I and Thou in order to explicate the nature of the normative form that is basic to his account of human being‐in‐relation. I apply this reading as a lens through which to re‐read and re‐orient his account of Man and Woman/Husband and Wife. I argue that the inequalities that appear intrinsic to Barth's formal ordering of Man and Woman/Husband and Wife owing to the absence of a standard concept of “equal regard” might be re‐oriented, and limitations of his account surpassed, by grasping with greater precision and enunciating the orientational implications of Barth's christologically‐anchored conception of freedom as the “root and crown” of human being‐in‐relation generally, and gendered relationship in particular.
A PANENTHEIST READING OF JOHN MILBANK
Authors: MIR AMENE 
Published: May 2012

AbstractJohn Milbank contends that modernity's attempt to establish an autonomous and secular realm for finite reality derives from a theological error originating primarily in the thought of Duns Scotus. Here both divine and finite reality share in a transcendental univocal Being that understands the divine as merely an extrinsic presence. Addressing this error, Milbank seeks to return to a participatory orthodoxy. This article will argue that in such a return Milbank qualifies in important ways the classical understanding of God's relation to creation and the divine attributes, allowing for a panentheist reading of his work that is both asymmetrical and dipolar in character.
Infrastructure: Real Assets and Real Returns
Authors: Bird Ron , Liem Harry , Thorp Susan 
Published: May 2012

AbstractLittle empirical work has been done on infrastructure as an asset class despite increased allocations by institutional investors. We build a robust factor model of infrastructure returns using US and Australian infrastructure and utility data to test manager claims that infrastructure investments offer benefits via a combination of monopolistic and defensive assets. We find evidence of excess returns and inflation hedging, but not of defensive characteristics. We compare option‐based models designed to replicate infrastructure asset returns, and identify the regulatory risk premium. A combination of inflation linked bonds and covered call strategies results in improved defensive and inflation hedging characteristics.
Discovering Immigration into Turkey: The Emergence of a Dynamic Field
Authors: Tolay Juliette 
Published: May 2012

AbstractIn the last couple of decades, Turkey has become an important country of immigration. In parallel, a new scholarly field has developed to study this largely unrecognized phenomenon. In this paper, I take stock of this new literature. I first show how students of immigration into Turkey had to define the field in relation to the powerful existing fields studying emigration from Turkey and internal migration in Turkey, as well as how they distinguished between “old” and “new” immigration. I then study the emergence of this field under the lead of Ahmet İçduygu and Kemal Kirişci. Later, with the establishment of two central research centres (CARIM and MiReKoç), the field gained important institutional anchors and attracted many new scholars. Today, the field is characterized by a strong dynamism, a plurality of talented scholars and a diversity of concerns and approaches. Even though the field is still at an early stage, it is bound to grow rapidly, as the phenomenon of migration into Turkey remains a highly strategic and lasting phenomenon. It is therefore crucial for the field to become self‐aware of its strength and weaknesses. Consequently, in the final section, I identify important future directions for the field, especially the need for scholars to better understand the diverse political ramifications (foreign and domestic politics) associated with immigration into Turkey.
Genetic variations of patients with familial or multiple melanoma in Southern Brazil
Authors: Grazziotin T.C. , Rey M.C.W. , Bica C.G. , Pinto L.A. , Bonamigo R.R. , Puig‐Butille J.A. , Cuellar F. , Puig S. 
Published: May 2012

AbstractBackground  Patients with familial melanoma or multiple primary melanoma represent a high‐risk population to hereditary melanoma. Mutations in susceptibility genes, such as CDKN2A, CDK4 and MC1R, have been associated with the development of melanoma.Objectives  The purpose of this study was to determine the genotypic background of patients with familial and/or multiple melanoma in southern Brazil.Methods  This study analysed 33 cases (5 patients with multiple primary melanoma and 28 patients from families with at least two well documented cases) and 29 controls. Genomic analysis of CDKN2A and CDK4 genes by PCR‐SSCP analysis and sequencing and direct sequencing of MC1R were performed in all individuals.Results  No functional mutations in CDKN2A or CDK4 were detected in the 62 individuals. Infrequent variants in polymorphic loci of CDKN2A gene were identified in 15 participants (24.2%) and 24/33 (72.8%) cases and 19/27 (70.4%) controls reported at least one infrequent variant in MC1R (P = 0.372). Furthermore, a non‐significant tendency towards an association between melanoma risk and MC1R variants G274A and C451T and a non‐significant linear tendency to the number of infrequent high‐risk variants in MC1R were observed.Conclusions  These results suggest that in southern Brazilian population, CDKN2A or CDK4 germinal alterations may have a weaker influence than previously thought and environmental risk factors may play a central role in melanoma susceptibility. However, considering the tendency observed for gene MC1R, low‐penetrance genes may be a relevant aetiological factor in southern Brazil with fair skin population and high sunlight exposure.
Plasma YKL‐40: a potential biomarker for psoriatic arthritis?
Authors: Jensen P. , Wiell C. , Milting K. , Poggenborg R.P. , Østergaard M. , Johansen J.S. , Skov L. 
Published: May 2012

AbstractBackground  Plasma YKL‐40 is an inflammatory biomarker. No useful biomarker exists in patients with psoriasis or psoriatic arthritis.Objective  To measure YKL‐40 and high‐sensitivity C‐reactive protein (hs‐CRP) in patients with psoriasis or psoriatic arthritis before and during treatment.Methods  In 48 patients with psoriasis, we measured YKL‐40, hs‐CRP and Psoriasis Area and Severity Index (PASI) at inclusion and in a subgroup of 14 patients, we repeated the measurements after four to six weeks of methotrexate treatment. In 42 patients with psoriatic arthritis, we measured YKL‐40 and hs‐CRP at inclusion and during 48 weeks of adalimumab treatment. The patients with psoriatic arthritis were divided into responders and non‐responders.Results  In patients with psoriasis, the baseline median PASI score was 10.8 and baseline YKL‐40 was 45 μg/L. Seventeen per cent had elevated plasma YKL‐40 compared with healthy subjects. Baseline PASI and YKL‐40 were not correlated (rho = 0.14, P = 0.347) and YKL‐40 and hs‐CRP remained unchanged after treatment.In patients with psoriatic arthritis, the median pretreatment YKL‐40 was 112 μg/L and 43% had elevated YKL‐40. YKL‐40 decreased in 33 patients who responded to adalimumab (from 112 μg/L to 68 at 48 weeks, P = 0.007). Hs‐CRP decreased (from 4.65 mg/L to 0.91, P = 0.013) in the responders. In the non‐responders (n = 9), YKL‐40 and hs‐CRP remained unchanged.Conclusions  YKL‐40 is elevated in many patients with psoriatic arthritis, but not in patients with psoriasis. YKL‐40 decreased in patients with psoriatic arthritis who responded to treatment. YKL‐40 may be a useful biomarker to monitor the effect of treatment with tumour necrosis factor‐α inhibitors in patients with psoriatic arthritis.
Doing it together (DM Special Issue)
Authors: Gary Butler , Amanda Cresswell , Nikoletta Giatras , Irene Tuffrey‐Wijne 
Published: May 2012

Accessible summary

We are a team of four researchers, two of whom have learning disabilities.
We did two studies using focus groups with people with learning disabilities. One study was about ‘What is it like for people with learning disabilities to have someone in their family or a friend with cancer?’ The other study was about ‘How to break bad news to people with learning disabilities?’
This article tells the story of how we did focus groups together. The researchers with learning disabilities helped to plan, to run the groups and to look at the results afterwards.
We did different things in the focus groups. We talked together and also used storytelling, role‐play and voting.
Researchers with learning disabilities can really help the group to open up and talk about difficult subjects.

SummaryThis paper presents two studies using focus groups with people with learning disabilities. One study was about ‘What is it like for people with learning disabilities who have a family or friend with cancer?’ and other study was about ‘How to break bad news to people with learning disabilities?’ Two of the researchers had learning disabilities themselves. This article reports how we worked together as a team. The focus groups involved various methods for data collection such as storytelling, role‐playing and voting. Researchers with learning disabilities enable participants with learning disabilities to discuss difficult subjects.
Yes! I am a researcher. The research story of a young adult with Down syndrome
Authors: White Emma L. , Morgan Michelle F. 
Published: May 2012

Accessible summary
My name is Emma.
I am 28 years old and I have Down syndrome.
This is my story about becoming a researcher.
This article

Has lots of photographs of me doing research.
Information about the things I did with research.
Has some examples of some of my research work.
Lets me share my story with other people.
Shows that I can do anything at all times.
Is about me becoming a real researcher.

It is important for people to know that people with Down syndrome have disabilities but this does not stop me from being a superwoman!SummaryMy name is Emma I am 28 years old and I have Down syndrome.This is an article about my story about becoming a researcher.This article has lots of photographs of me doing research. It has information about the things I did with research. It has examples of some of my research work. This article lets me share my story with other people. This article shows that I can do anything at all times, and the photographs of me being a researcher prove it.This research project was about finding out about the everyday literacy of three young adults with intellectual disability. Two of us have Down syndrome. It was also about us becoming real researchers.People with Down syndrome have disabilities but this does not stop me from being a superwoman!
Heidi's and Philip's stories: transitions to post‐secondary education
Authors: Wilson Heidi , Bialk Philip , Freeze Trevi B. , Freeze Rick , Lutfiyya Zana M. 
Published: May 2012

Accessible summary

In this article, the formative childhood and adolescent experiences of two young adults with learning disabilities, leading to their transitions from high school to university, are chronicled.
Their university studies, as auditing students,1 and the Campus Life program2 through which their studies were supported, also are described.
Finally, their recommendations to other young people with learning disabilities who aspire to higher education are detailed.

Benefits to people with Learning Disabilities:It is always important to hear, and help others hear, the voices, thoughts and perspectives of people with learning disabilities, especially with respect to what they think contributes to a good life. This is the story of two young adults with learning disabilities, Heidi and Philip, studying at an advanced level, deciding on real careers and, in the process, helping the university to redefine its role in the community.SummaryBuilding a meaningful and valued life for individuals with learning disabilities requires the sustained, diligent and coordinated efforts of family members, supporters, educators and the individuals themselves. In this article, the formative childhood and adolescent experiences of two young adults with learning disabilities, leading to their transitions from high school to university, are chronicled. As co‐authors with three of their university supporters, they describe their formative experiences in elementary and secondary school and the transition years that preceded university entry. Their university studies, as auditing students, and the Campus Life program, through which their studies were supported, also are described. Finally, their recommendations to other young people with learning disabilities who aspire to higher education are detailed.
Influence of ethnicity and socioeconomic factors on outcome after total hip replacement
Authors: Krupic Ferid , Eisler Thomas , Garellick Göran , Kärrholm Johan 
Published: May 2012

Scand J Caring Sci; 2013; 27; 139–146

Influence of ethnicity and socioeconomic factors on outcome after total hip replacement
Background:  Previous studies have documented ethnic differences in the utilization of total hip arthroplasty. Less is known if this operation is performed at the same stage of symptoms and has equal effects in patients with different ethnicity.Aim:  We investigated whether patients born outside Sweden report equal effects of operation with the insertion of a total hip replacement in terms of EQ‐5D, pain and overall satisfaction as those born in Sweden.Method:  Preoperative and 1‐year postoperative data from Swedish Hip Arthroplasty Register, (1216 patients,1216 hips) with primary osteoarthritis of the hip operated between years 2002 and 2006, were analysed. All patients completed the EQ‐5D form, filled in a VAS about pain preoperatively and at 1 year postoperatively, when a VAS about overall satisfaction was added.Findings:  Before the operation and after adjustment for confounders, patients born abroad reported more problems (dichotomized into no or moderate/severe problems), with self‐care (p = 0.01) and anxiety/depression (p = 0.02) in the EQ‐5D form than those born in Sweden. They also had more pain (VAS, p = 0.04). One year after the operation and after statistical adjustments, patients born outside Sweden reported lower scores for self‐care (p = 0.008) and usual activities (p = 0.001) in the EQ‐5D form. They still reported more pain (VAS, p = 0.02), but no significant difference concerning degree of satisfaction (p = 0.3).Conclusions:  Our finding of more preoperative disability and pain (VAS) before the operation in patients born abroad might depend on cultural differences, communication problems and differences in indications. Even if the effect of the total hip replacement was good, patients born abroad scored less for some of the items at 1 year. We think that this patient group could benefit from improved pre‐ and postoperative information and other measures to facilitate and improve their rehabilitation.
Diabetes and end of life: ethical and methodological issues in gathering evidence to guide care
Authors: Dunning Trisha , Duggan Nicole , Savage Sally , Martin Peter 
Published: May 2012

Scand J Caring Sci; 2013; 27; 203–211

Diabetes and end of life: ethical and methodological issues in gathering evidence to guide care
Introduction:  Providing palliative care for people with diabetes at the end of life is part of the chronic disease care trajectory, but end of life care is complex and the presence of diabetes further complicates management.Aim:  The aim of the paper is to discuss the ethical and methodological issues encountered when undertaking research to develop guidelines for managing diabetes at the end of life and the strategies used to address the issues.Method:  The issues emerged as we developed guidelines for managing diabetes at the end of life, which included conducting individual interviews with 14 people with diabetes requiring palliative care and 10 family members. A reflexive researcher journal was maintained throughout the guideline development process. The interview transcripts and researcher’s journal were analysed to determine key methodological, ethical and researcher‐related issues.Findings:  Key themes were vulnerability of the sampling population, methodological issues included recruiting participants and ensuring rigor, ethical issues concerned benefit and risk, justice, autonomy, privacy, professional boundaries and informed consent. Researcher‐related issues were identified such as managing participant distress and their own emotional distress. People were willing to discuss end of life diabetes management preferences.Conclusions:  Undertaking research with people at the end of life is complex because of their vulnerability and the ethical issues involved. However, the ethical principles of autonomy and justice apply and people should be given the relevant information and opportunity to decide whether to participate or not.