bluuebunny/crossref_metadata_2025_split huggingface dataset:
CETL for work based learning: enhancing innovation and creativity in teaching and learning
Authors: Workman Barbara , Armsby Pauline , Durrant Alan , Frame Philip 
Published: October 2011

PurposeThe purpose of this paper is to discuss three case studies reflecting areas of innovation and creativity which CETL funding made possible through a work‐based learning CETL. CETL sponsored evaluations of funded projects and teaching initiatives informed further curriculum developments.Design/methodology/approachUsing a case study approach the paper explores the experiences of three different projects and the impact upon staff and students in a CETL for work‐based learning. Three case studies are used, the first describing progression from a Performing Arts Diploma to a degree, facilitated by the use of learning technologies and social networking; the second considers the impact upon experienced professionals and stakeholders involved in a new Doctorate programme by Public Works. The third case study demonstrates the importance of rewarding investment in and evaluation of learning approaches, assisted by learning technology, with the resultant development of a model which facilitates reflective learning from work activities. Case studies were focused on teaching and learning practice.FindingsThese were all programme developments which arose from practitioners and impacted upon academic practice and curriculum development. They impacted upon future learning initiatives thus demonstrating that the CETL investment impacted a wide range of learning activities at different academic levels. Dissemination of impact beyond the original project was evident through qualitative feedback and practitioner practice.Social implicationsThis was more of an analytical exploration of funded innovations in teaching and learning than formal research and therefore is not presented as traditional research. However, a case for case study approach in included, but data methods not explored.Practical implicationsThe CETL funding of teaching and learning innovations impacted upon work‐based learning and the student learning experience within several schools across the university. These innovations have become significant for future WBL curriculum developments within the University. It is also evidenced that additional funding for five years of the CETL project enabled projects to grow and develop over a period of time. Therefore the indications are that sustained funding and evaluations at development points contribute to embedding and enhancing academic curriculum innovations.Originality/valueThis paper highlights the importance of long‐term investment in teaching and learning initiatives and the impact that such investment can have over a period of time, particularly in relation to CETL funding, of which the long‐term effects on teaching and learning in HE are as yet unknown.
An auction‐based framework for resource allocation in disaster relief
Authors: Alp Ertem Mustafa , Buyurgan Nebil 
Published: October 2011

PurposeThe purpose of this paper is to address the inefficiency problems in procurement operations in disaster relief logistics which are mainly due to the lack of coordination among less organized suppliers and partnerships. Such problems lead to poor responsiveness and hinder timely procurement of required goods.Design/methodology/approachAn auction‐based framework for procurement of goods, which is suitable for a single coordinating platform in disaster relief logistics, is proposed. Integer programming formulations are used in auctioning operations. A simulation model that generates problem instances is used to evaluate and tune system‐level design parameters.FindingsDesign parameters greatly affect the behaviour and responsiveness of the system and the performance of the auction‐based framework in different problem instances. Combinations of those parameters may allow suppliers with limited capacities to become more involved in the bidding process. In addition, the procurement shares of bidders may change substantially with different values of the parameters.Research limitations/implicationsEven though the presented framework is inspired from real‐life applications, it is not implemented in real‐life disaster relief operations. The goodness of fit for the framework would best be evaluated by a real disaster case. In addition, transportation scheduling and vehicle routing considerations and budgeting issues are not considered in the framework.Originality/valueThis paper presents an auction‐based framework for less organized suppliers of goods and their partnerships, such as local humanitarian organizations, private companies, and standby partners. The presented framework offers a background for coordination during disaster relief operations which provides opportunities to act as a set of organized entities. This background also helps those entities coordinate their efforts to enhance the capabilities of local governments and NGOs.
Managing Machu Picchu: institutional settings, business model and master plans
Authors: Zan Luca , Lusiani Maria 
Published: October 2011

PurposeThe purpose of this paper is to analyze elements of continuity and change in the administrative history of the Historical Sanctuary of Machu Picchu (HSM) over the last decade.Design/methodology/approachBased on a field study and of both qualitative and quantitative data, the paper reconstructs changes in accounting and planning processes and discourses.FindingsAt the macro level, in the recent past Peru has gone through a process of modernization of the State, moving to more transparent and accountable forms of public management that deeply restructured the public sector. In parallel, the international community (particularly, UNESCO) has urged the adoption of a comprehensive strategic management plan for the HSM. Common to these pressures for change is a logic of efficiency, of rationalization and control of public expenditures and of more effective public services. At the micro level, these two pressures for change are shaping both the transformation of the accounting representation system and the managerial and planning practices in Machu Picchu.Originality/valueThe paper focuses on a description of the institutional settings in order to make sense of the multiple rationalities involved; second, a reconstruction of the underlying “business model” of the main entity involved in the administration of Machu Picchu (in terms of internal structure and scope, visitor performance, financial performances, human resources); and third, a focus on the progressive introduction of master planning as a practice.
Initial findings: primary diabetes care responsibility among emerging adults with type 1 diabetes post high school and move out of parental home
Authors: Hanna K. M. , Weaver M. T. , Stump T. E. , DiMeglio L. A. , Miller A. R. , Crowder S. , Fortenberry J. D. 
Published: October 2011

AbstractBackground  Emerging adults with diabetes are assuming diabetes care responsibility, graduating from high school and leaving their parental homes. We examined: (1) how diabetes care responsibility changed in relation to time (high school to post high school) and living situation (living independently or not of parents) and (2) the association of diabetes self‐efficacy, worry about hypoglycaemia, gender and glycaemic control with these changes in responsibility among emerging adults with type 1 diabetes.Methods  During the last 6 months in high school (T1), 113 participants completed diabetes care responsibility (total, daily and non‐daily), diabetes self‐efficacy and worry about hypoglycaemia scales. Participants again completed the responsibility scales post high school graduation (T2). We used a linear mixed‐effects model with diabetes self‐efficacy, worry about hypoglycaemia, time since graduation, living situation, gender and glycaemic control as independent variables; and diabetes care responsibility (total, daily and non‐daily) as dependent variables. Moderation involving diabetes self‐efficacy, worry about hypoglycaemia, gender and glycaemic control was also tested.Findings  Diabetes care responsibility increased over time for total (P < 0.001), daily (P= 0.002) and non‐daily (P < 0.001), but the associations of self‐efficacy and gender with diabetes care responsibility were moderated by living situation. Self‐efficacy was negatively related to total (P= 0.006), daily (P= 0.010) and non‐daily (P= 0.030) responsibility for those not living independently while positively related only to total responsibility (P= 0.028) for those living independently. Being female was positively related to total (P= 0.007) and non‐daily (P= 0.001) responsibility for those living independently.Conclusion  Diabetes care responsibility increased from high school to post high school among these emerging adults with diabetes. There is a complex relationship between self‐efficacy, gender and responsibility related to living independently of parents for these youth.
Renal differentiation of amniotic fluid stem cells: perspectives for clinical application and for studies on specific human genetic diseases
Authors: Rosner Margit , Schipany Katharina , Gundacker Claudia , Shanmugasundaram Bharanidharan , Li Kongzhao , Fuchs Christiane , Lubec Gert , Hengstschläger Markus 
Published: October 2011

Eur J Clin Invest 2012; 42 (6): 677–684Background  Owing to growing rates of diabetes, hypertension and the ageing population, the prevalence of end‐stage renal disease, developed from earlier stages of chronic kidney disease, and of acute renal failure is dramatically increasing. Dialysis and preferable renal transplantation are widely applied therapies for this incurable condition. However these options are limited because of morbidity, shortage of compatible organs and costs. Therefore, stem cell‐based approaches are becoming increasingly accepted as an alternative therapeutic strategy.Design  This review summarizes the current findings on the nephrogenic potential of amniotic fluid stem (AFS) cells and their putative implications for clinical applications and for studies on specific human genetic diseases.Results  Since their discovery in 2003, AFS cells have been shown to be pluripotent with the potential to form embryoid bodies. Compared to adult stem cells, induced pluripotent stem cells or embryonic stem cells, AFS cells harbour a variety of advantages, such as their high differentiation and proliferative potential, no need for ectopic induction of pluripotency and no somatic mutations and epigenetic memory of source cells, and no tumourigenic potential and associated ethical controversies, respectively.Conclusions  Recently, the results of different independent studies provided evidence that AFS cells could indeed be a powerful tool for renal regenerative medicine.
When are adaptive radiations replicated in areas? Ecological opportunity and unexceptional diversification in West Indian dipsadine snakes (Colubridae: Alsophiini)
Authors: Burbrink Frank T. , Ruane Sara , Pyron R. Alexander 
Published: October 2011

AbstractAim We examine diversification in Caribbean alsophiine snakes and hypothesize that, given the ecological opportunity presented by colonization of the West Indies, alsophiines should show the signature of an early burst of diversification and associated low within‐clade ecological and morphological disparification. We also test whether changes in morphology and ecology are associated with changes in diversification rate, as trait‐dependent diversification is hypothesized to affect historical inferences of diversification and disparification. Finally, as replicated radiations are found across the West Indies in the anoles, we test for significant differences in ecological and morphological assemblages and rates among the major island groups.Location The West Indies.Methods A time‐calibrated phylogeny produced from six genes using relaxed clock methods inbeastwas constructed to estimate ancestral areas using Lagrange. Maximum body size and ecological niche were scored for all species in the phylogeny, and comparative phylogenetic methods in R usinggeiger,laser,apeand our own code were used to examine diversification through time, disparification and trait‐dependent diversification from this dated phylogeny.Results The pattern of species diversification did not differ significantly from the Yule model of diversification. Morphology and ecology fitted a Brownian and white noise model of diversification, respectively. Although not significantly different, morphological disparification was lower than the Brownian null model, whereas ecological disparification was significantly greater than the null. Trait‐dependent diversification analyses suggested that the constant null models provided the best fit to these data. There was no significant signal of rate variation among the major island groups for size, but moderate evidence for niche.Main conclusions Although ecological opportunity was similarly present for alsophiines as it was for anoles, the snakes fail to show an early burst of speciation. Potential reasons for this include the young age of the group, and staggered diversification due to waiting times between island colonization. In turn, ecological and morphological disparities do not necessarily follow predictable patterns related to species diversification. Thus, the presence of ecological opportunity alone is not necessarily sufficient to trigger replicated adaptive radiations in areas.
Sociality, individual fitness and population dynamics of yellow‐bellied marmots
Authors: ARMITAGE KENNETH B. 
Published: October 2011

AbstractSocial behaviour was proposed as a density‐dependent intrinsic mechanism that could regulate an animal population by affecting reproduction and dispersal. Populations of the polygynous yellow‐bellied marmot (Marmota flaviventris) fluctuate widely from year to year primarily driven by the number of weaned young. The temporal variation in projected population growth rate was driven mainly by changes in the age of first reproduction and fertility, which are affected by reproductive suppression. Dispersal is unrelated to population density, or the presence of the father; hence, neither of these limits population growth or acts as an intrinsic mechanism of population regulation; overall, intrinsic regulation seems unlikely. Sociality affects the likelihood of reproduction in that the annual probability of reproducing and the lifetime number of offspring are decreased by the number of older females and by the number of same‐aged females present, but are increased by the number of younger adult females present. Recruitment of a yearling female is most likely when her mother is present; recruitment of philopatric females is much more important than immigration for increasing the number of adult female residents. Predation and overwinter mortality are the major factors limiting the number of resident adults. Social behaviour is not directed towards population regulation, but is best interpreted as functioning to maximize direct fitness.
Quantitative proteomics reveals metabolic and pathogenic properties of Chlamydia trachomatis developmental forms
Authors: Saka Hector A. , Thompson J. Will , Chen Yi‐Shan , Kumar Yadunanda , Dubois Laura G. , Moseley M. Arthur , Valdivia Raphael H. 
Published: October 2011

SummaryChlamydia trachomatis is an obligate intracellular pathogen responsible for ocular and genital infections of significant public health importance. C. trachomatis undergoes a biphasic developmental cycle alternating between two distinct forms: the infectious elementary body (EB), and the replicative but non‐infectious reticulate body (RB). The molecular basis for these developmental transitions and the metabolic properties of the EB and RB forms are poorly understood as these bacteria have traditionally been difficult to manipulate through classical genetic approaches. Using two‐dimensional liquid chromatography – tandem mass spectrometry (LC/LC‐MS/MS) we performed a large‐scale, label‐free quantitative proteomic analysis of C. trachomatis LGV‐L2 EB and RB forms. Additionally, we carried out LC‐MS/MS to analyse the membranes of the pathogen‐containing vacuole (‘inclusion’). We developed a label‐free quantification approaches to measure protein abundance in a mixed‐proteome background which we applied for EB and RB quantitative analysis. In this manner, we catalogued the relative distribution of > 54% of the predicted proteins in the C. trachomatis LGV‐L2 proteome. Proteins required for central metabolism and glucose catabolism were predominant in the EB, whereas proteins associated with protein synthesis, ATP generation and nutrient transport were more abundant in the RB. These findings suggest that the EB is primed for a burst in metabolic activity upon entry, whereas the RB form is geared towards nutrient utilization, a rapid increase in cellular mass, and securing the resources for an impending transition back to the EB form. The most revealing difference between the two forms was the relative deficiency of cytoplasmic factors required for efficient type III secretion (T3S) in the RB stage at 18 h post infection, suggesting a reduced T3S capacity or a low frequency of active T3S apparatus assembled on a ‘per organism’ basis. Our results show that EB and RB proteomes are streamlined to fulfil their predicted biological functions: maximum infectivity for EBs and replicative capacity for RBs.
Genome‐wide LORE1 retrotransposon mutagenesis and high‐throughput insertion detection in Lotus japonicus
Authors: Urbański Dorian Fabian , Małolepszy Anna , Stougaard Jens , Andersen Stig Uggerhøj 
Published: October 2011

SummaryUse of insertion mutants facilitates functional analysis of genes, but it has been difficult to identify a suitable mutagen and to establish large populations for reverse genetics in most plant species. The main challenge is developing efficient high‐throughput procedures for both mutagenesis and identification of insertion sites. To date, only floral‐dip T‐DNA transformation of Arabidopsis has produced independent germinal insertions, thereby allowing generation of mutant populations from seeds of single plants. In addition, advances in insertion detection have been hampered by a lack of protocols, including software for automated data analysis, that take full advantage of high‐throughput next‐generation sequencing. We have addressed these challenges by developing the FSTpoolit protocol and software package, and here we demonstrate its efficacy by detecting 8935 LORE1 insertions in 3744 Lotus japonicus plants. The identified insertions show that the endogenous LORE1 retrotransposon is well suited for insertion mutagenesis due to homogenous gene targeting and exonic insertion preference. As LORE1 transposition occurs in the germline, harvesting seeds from a single founder line and cultivating progeny generates a complete mutant population. This ease of LORE1 mutagenesis, combined with the efficient FSTpoolit protocol, which exploits 2D pooling, Illumina sequencing and automated data analysis, allows highly cost‐efficient development of a comprehensive reverse genetic resource.
Latent structure of unipolar and bipolar mood symptoms
Authors: Ahmed Anthony O , Green Bradley A , Clark Charles B , Stahl Karyn C , McFarland Megan E 
Published: October 2011

Ahmed AO, Green BA, Clark CB, Stahl KC, McFarland ME. Latent structure of unipolar and bipolar mood symptoms.  Bipolar Disord 2011: 13: 522–536. © 2011 The Authors. Journal compilation © 2011 John Wiley & Sons A/S.Objectives:  The taxonic versus dimensional status of mood symptoms has been the subject of debate among mental health professionals. Conventional diagnostic models suggest that mood disorders are categorical; however, the inability of categorical models to adequately account for subthreshold unipolar and bipolar presentations and the heterotypic continuity of symptoms in unipolar and bipolar cases has resulted in growing support for dimensional views. The current study sought to evaluate the relative viabilities of categorical and dimensional models of mood symptoms within a taxometric framework.Methods:  We examined the latent structure of mood symptoms in an epidemiological sample drawn from the Collaborative Psychiatric Epidemiological Surveys. Using three taxometric procedures (MAMBAC, MAXEIG, and L‐Mode), we analyzed indicators of mania and depression created from the mood symptoms section of the survey.Results:  The taxometric analyses supported a taxonic rather than dimensional structure for mania and depression. Membership in the mania and depressive taxa was associated with meeting criteria for DSM‐IV lifetime manic episode and major depressive disorder, respectively. We identified a subset of 700 individuals falling into both taxa; membership in this subset was associated with lifetime bipolar disorder status. Group membership predicted designated external variables including help‐seeking, family history, and duration of impairment. Within taxon and/or complement groups, severity scores still appeared to predict external variables.Conclusion:  Our findings suggest that although taxonic, mood disorders possess meaningful dimensional variation.
Outcomes in patients with Gleason score 8–10 prostate cancer: relation to preoperative PSA level
Authors: McGuire Barry B. , Helfand Brian T. , Loeb Stacy , Hu Qiaoyan , O'Brien Daniel , Cooper Phillip , Yang Ximing , Catalona William J. 
Published: October 2011

Study Type – Therapy (case series)Level of Evidence 4What's known on the subject? and What does the study add?High‐grade prostate cancers are associated with poor disease‐specific outcomes. A proportion of these tumours produce little PSA.This study demonstrates that among Gleason 8–10 prostate cancers, some of the worst survival outcomes are associated with the lowest PSA levels.OBJECTIVE
To assess outcomes of patients with Gleason score 8–10 prostate cancer (CaP) with a low (≤2.5 ng/mL) vs higher preoperative serum PSA levels.
PATIENTS AND METHODS
From 1983 to 2003, 5544 patients underwent open radical prostatectomy, of whom 354 had a Gleason 8–10 tumour in the prostatectomy specimen.
Patients were stratified according to preoperative PSA level into four strata: ≤2.5 ng/mL (n= 31), 2.6–4 ng/mL (n= 31), 4.1–10 ng/mL (n= 174), and >10 ng/mL (n= 118).
We compared biochemical progression‐free survival (PFS), metastasis‐free survival (MFS), and cancer‐specific survival (CSS) as a function of preoperative PSA level.
RESULTS
Patients with PSA level ≤2.5 ng/mL were more likely to have seminal vesicle invasion (P= 0.003).
On Kaplan–Meier survival analysis, patients with a PSA level ≤2.5 ng/mL had proportionately worse outcomes than their counterparts with higher PSA levels.
The 7‐year PFS in the PSA ≤2.5 ng/mL stratum was lower than those of the PSA 2.6–4 ng/mL and 4–10 ng/mL strata (36% vs 50 and 42%, respectively); however, the lowest 7‐year PFS was found in those with a PSA level >10 ng/mL (32%, P= 0.02).
Gleason score 8–10 tumours with a PSA level ≤2.5 ng/mL also tended to have the lowest 7‐year MFS (75, 93, 89 and 92% for PSA level ≤2.5, 2.6–4, 4.1–10 and >10 ng/mL, respectively, P= 0.2) and CSS (81, 100, 94 and 90% for PSA level ≤2.5, 2.6–4, 4.1–10 and >10 ng/mL, respectively, P= 0.3), although these differences were not statistically significant.
In the subset with palpable disease, Gleason grade 8–10 disease with PSA level ≤2.5 ng/mL also was associated with a worse prognosis.
CONCLUSIONS
In patients with Gleason grade 8–10 disease, a proportion of these tumours are so poorly differentiated that they produce relatively little PSA.
Patients with high‐grade, low‐PSA tumours had less favourable outcomes than many of those with higher PSA levels.