bluuebunny/crossref_metadata_2025_split huggingface dataset:
Directed migration of human neural progenitor cells to interleukin-1β is promoted by chemokines stromal cell-derived factor-1 and monocyte chemotactic factor-1 in mouse brains
Authors: Wu Yumei , Chen Qiang , Peng Hui , Dou Huanyu , Zhou You , Huang Yunlong , Zheng Jialin C 
Published: July 2012

AbstractBackgroundNeurogenesis, including the proliferation, migration and differentiation of neural progenitor cells (NPCs), is impaired in HIV-1 associated dementia (HAD). We previously demonstrated HIV-1-infected macrophages (HIV-MDM) regulate stromal cell-derived factor 1 (SDF-1) production in astrocytes through Interleukin-1β (IL-1β). Chemokines are known to induce NPC migration; however, it remains unclear how chemokines produced in inflammation regulate NPC migration.MethodsThe secretion of SDF-1 and Monocyte chemotactic preotein-1 (MCP-1) in astrocytes upon IL-1β stimulation was measured by ELISA assay.Human NPCs were injected parallel along with IL-1β, SDF-1 or MCP-1 intracranially into basal ganglion 1 mm apart in SCID mice, and immunofluorescent staining was used to study the survival and migration of injected human NPCs.ResultsSDF-1 and MCP-1 are secreted by astrocytes upon IL-1β stimulation in a time-dependent manner. Injected human NPCs survived in SCID mice and migrated towards sites of IL-1β, SDF-1 and MCP-1 injection.ConclusionsIn conclusion, chemokines SDF-1 or MCP-1 secreted by astrocytes in the presence of IL-1β injection are attractive to NPCs injected into SCID mouse brains, suggesting that SDF-1 and MCP-1 play important roles in NPC migration during neuroinflammation.
Induction Chemotherapy and Conformal Radiation Therapy for Very Young Children With Nonmetastatic Medulloblastoma: Children's Oncology Group Study P9934
Authors: Ashley David M. , Merchant Thomas E. , Strother Douglas , Zhou Tianni , Duffner Patricia , Burger Peter C. , Miller Douglas C. , Lyon Nancy , Bonner Melanie J. , Msall Michael , Buxton Allen , Geyer Russell , Kun Larry E. , Coleman Lee , Pollack Ian F. 
Published: July 2012

Purpose P9934 was a prospective trial of systemic chemotherapy, second surgery, and conformal radiation therapy (CRT) limited to the posterior fossa and primary site for children between 8 months and 3 years old with nonmetastatic medulloblastoma. The study was open from June 2000 until June 2006. Patients and Methods After initial surgery, children received four cycles of induction chemotherapy, followed by age- and response-adjusted CRT to the posterior fossa (18 or 23.4 Gy) and tumor bed (cumulative 50.4 or 54 Gy) and maintenance chemotherapy. Neurodevelopmental outcomes were evaluated and event-free survival (EFS) results were directly compared with a previous study of multiagent chemotherapy without irradiation (Pediatric Oncology Group [POG] trial 9233). Results Seventy-four patients met eligibility requirements. The 4-year EFS and overall survival probabilities were 50% ± 6% and 69% ± 5.5%, respectively, which compared favorably to the results from POG 9233. Analysis showed that the desmoplastic/nodular subtype was a favorable factor in predicting survival. Our 4-year EFS rate was 58% ± 8% for patients with desmoplasia. Whereas seven of 10 patients who had disease progression before CRT had primary-site failure, 15 of 19 patients who progressed after CRT had distant-site failure. Neurodevelopmental assessments did not show a decline in cognitive or motor function after protocol-directed chemotherapy and CRT. Conclusion The addition of CRT to postoperative chemotherapy in young children with nonmetastatic medulloblastoma increased event-free survival compared with the use of postoperative chemotherapy alone. Future studies will use histopathologic typing (desmoplastic/nodular versus nondesmoplastic/nodular) to stratify patients for therapy by risk of relapse.
Concurrent Expression of MYC and BCL2 in Diffuse Large B-Cell Lymphoma Treated With Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone
Authors: Johnson Nathalie A. , Slack Graham W. , Savage Kerry J. , Connors Joseph M. , Ben-Neriah Susana , Rogic Sanja , Scott David W. , Tan King L. , Steidl Christian , Sehn Laurie H. , Chan Wing C. , Iqbal Javeed , Meyer Paul N. , Lenz Georg , Wright George , Rimsza Lisa M. , Valentino Carlo , Brunhoeber Patrick , Grogan Thomas M. , Braziel Rita M. , Cook James R. , Tubbs Raymond R. , Weisenburger Dennis D. , Campo Elias , Rosenwald Andreas , Ott German , Delabie Jan , Holcroft Christina , Jaffe Elaine S. , Staudt Louis M. , Gascoyne Randy D. 
Published: July 2012

Purpose Diffuse large B-cell lymphoma (DLBCL) is curable in 60% of patients treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). MYC translocations, with or without BCL2 translocations, have been associated with inferior survival in DLBCL. We investigated whether expression of MYC protein, with or without BCL2 protein expression, could risk-stratify patients at diagnosis. Patients and Methods We determined the correlation between presence of MYC and BCL2 proteins by immunohistochemistry (IHC) with survival in two independent cohorts of patients with DLBCL treated with R-CHOP. We further determined if MYC protein expression correlated with high MYC mRNA and/or presence of MYC translocation. Results In the training cohort (n = 167), MYC and BCL2 proteins were detected in 29% and 44% of patients, respectively. Concurrent expression (MYC positive/BCL2 positive) was present in 21% of patients. MYC protein correlated with presence of high MYC mRNA and MYC translocation (both P < .001), but the latter was less frequent (both 11%). MYC protein expression was only associated with inferior overall and progression-free survival when BCL2 protein was coexpressed (P < .001). Importantly, the poor prognostic effect of MYC positive/BCL2 positive was validated in an independent cohort of 140 patients with DLBCL and remained significant (P < .05) after adjusting for presence of high-risk features in a multivariable model that included elevated international prognostic index score, activated B-cell molecular subtype, and presence of concurrent MYC and BCL2 translocations. Conclusion Assessment of MYC and BCL2 expression by IHC represents a robust, rapid, and inexpensive approach to risk-stratify patients with DLBCL at diagnosis.
Phase II Study of Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone Immunochemotherapy Followed by Yttrium-90–Ibritumomab Tiuxetan in Untreated Mantle-Cell Lymphoma: Eastern Cooperative Oncology Group Study E1499
Authors: Smith Mitchell R. , Li Hailun , Gordon Leo , Gascoyne Randy D. , Paietta Elisabeth , Forero-Torres Andres , Kahl Brad S. , Advani Ranjana , Hong Fangxin , Horning Sandra J. 
Published: July 2012

PurposeTo test the hypothesis that consolidation therapy with yttrium-90 (90Y) –ibritumomab tiuxetan after brief initial therapy with four cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in patients with previously untreated mantle-cell lymphoma would be a well-tolerated regimen that would improve outcomes compared with historical R-CHOP data.Patients and MethodsPatients ≥ 18 years old with histologically confirmed mantle-cell lymphoma expressing CD20 and cyclin D1 who had not received any previous therapy and had an Eastern Cooperative Oncology Group performance status of 0 to 2 and adequate organ function were eligible. The study enrolled and treated 57 patients, of whom 56 patients were eligible. Fifty-two patients (50 eligible patients) received90Y-ibritumomab tiuxetan. The study design required 52 eligible patients to detect a 50% improvement in the median time to treatment failure (TTF) compared with that reported for six cycles of R-CHOP.ResultsWith 56 analyzed patients (median age, 60 years; men, 73%), the overall response rate was 82% (55% complete response/complete response–unconfirmed). With a median follow-up of 72 months, the median TTF was 34.2 months. The median overall survival (OS) has not been reached, with an estimated 5-year OS of 73% (79% for patients ≤ age 65 years v 62% for patients > age 65 years; P = .08 [log-rank test]). There were no unexpected toxicities.ConclusionR-CHOP given for four cycles followed by90Y–ibritumomab tiuxetan compared favorably with historical results with six cycles of R-CHOP in patients with previously untreated mantle-cell lymphoma. This regimen was well tolerated and should be applicable to most patients with this disease.
Multidisciplinary Care and Pursuit of Active Surveillance in Low-Risk Prostate Cancer
Authors: Aizer Ayal A. , Paly Jonathan J. , Zietman Anthony L. , Nguyen Paul L. , Beard Clair J. , Rao Sandhya K. , Kaplan Irving D. , Niemierko Andrzej , Hirsch Michelle S. , Wu Chin-Lee , Olumi Aria F. , Michaelson M. Dror , D'Amico Anthony V. , Efstathiou Jason A. 
Published: July 2012

Purpose Multidisciplinary clinics offer a unique approach to the management of patients with cancer. Yet, limited data exist to show that such clinics affect management. The purpose of this study was to determine whether consultation at a multidisciplinary clinic is associated with selection of active surveillance in patients with low-risk prostate cancer. Patients and Methods The study comprised 701 men with low-risk prostate cancer managed at three tertiary care centers in Boston, MA in 2009. Patients either obtained consultation at a multidisciplinary prostate cancer clinic, at which they were seen by a combination of urologic, radiation, and medical oncologists in a concurrent setting, or they were seen by individual practitioners in sequential settings. The primary outcome was selection of active surveillance. Results Crude rates of selection of active surveillance in patients seen at a multidisciplinary clinic were double that of patients seen by individual practitioners (43% v 22%), whereas the proportion of men treated with prostatectomy or radiation decreased by approximately 30% (P < .001). On multivariate logistic regression, older age (odds ratio [OR], 1.09; 95% CI, 1.05 to 1.12; P < .001), unmarried status (OR, 1.66; 95% CI, 1.01 to 2.72; P = .04), increased Charlson comorbidity index (OR, 1.37; 95% CI, 1.06 to 1.77; P = .02), fewer positive cores (OR, 0.92; 95% CI, 0.90 to 0.94; P < .001), and consultation at a multidisciplinary clinic (OR, 2.15; 95% CI, 1.13 to 4.10; P = .02) were significantly associated with pursuit of active surveillance. Conclusion Multidisciplinary care is associated with increased selection of active surveillance in men with low-risk prostate cancer. This finding may have an important clinical, social, and economic impact.
“Who Is the Macho Who Wants to Kill Me?” Male Homosexuality, Revolutionary Masculinity, and the Brazilian Armed Struggle of the 1960s and 1970s
Authors: Green James N. 
Published: July 2012

Abstract
Several thousand students joined small clusters of soldiers, workers, and others in revolutionary opposition to the Brazilian civilian-military dictatorship that came to power in 1964 and controlled the government for two decades. Operating underground, these left-wing activists engaged in diverse efforts to organize an effective guerrilla opposition to the authoritarian regime. Within their ranks, some militants who had homosexual desires faced a hegemonic culture of the left that considered same-sex sexuality a reflection of “bourgeois decadence,” an immoral aberration, and an affront to proper revolutionary behavior. This article explores how leftist Brazilians with homoerotic desires negotiated norms of compulsory heterosexuality and constructions of revolutionary masculinity in the 1960s and 1970s as they lived in the underground, among members of different political organizations while imprisoned, or in political exile.
Photoreduced Deformylation of Zinc Chlorophyll-d Derivative
Authors: Tamiaki Hitoshi , Xu Meiyun , Machida Shinnosuke 
Published: July 2012

Abstract
Photochemical reaction of a zinc chlorophyll-d derivative possessing a formyl group at the 3-position with a reductant in a deaerated alcoholic solution gave the corresponding 3-unsubstituted chlorin in 43% yield based on consumed starting material. The novel deformylation was accompanied by expected 2,3- or 7,8-dihydrogenation to give minor products possessing a isobacteriochlorin or bacteriochlorin π-system, respectively, as stereochemical mixtures.
Synthesis and Properties of Ni–Cu Alloy Supported on Mg–Al Mixed Oxide Catalyst for Automotive Exhaust
Authors: Kang Chun Yong , Taniguchi Masashi , Uenishi Mari , Tanaka Hirohisa 
Published: July 2012

Abstract
A new Cu-based catalyst for automotive three way catalysts has been investigated. We succeeded in the synthesis of the Ni–Cu alloy supported on Mg–Al mixed oxide catalyst, Ni0.3Cu0.2/2MgO·1/2MgAl2O4. On the NO–CO reaction evaluation after pretreatment in oxidation atmosphere, the Ni0.3Cu0.2/2MgO·1/2MgAl2O4 showed higher activity than a Cu/Al2O3 catalyst. In the evaluation by using model gas simulated automotive exhaust, the Ni0.3Cu0.2/2MgO·1/2MgAl2O4 catalyst showed high catalytic activity, especially for hydrocarbon oxidation in reducing atmosphere.
Synthesis of a Dendrimer Reactor for Clusters with a Magic Number
Authors: Kitazawa Hirokazu , Albrecht Ken , Yamamoto Kimihisa 
Published: July 2012

Abstract
A new type of phenylazomethine dendrimer (DPA) that has one more coordination site compared to the tetraphenylmethane core DPA was synthesized for the “magic number 13” metal cluster template that has cubic or hexagonal densely packed structures. The stepwise complexation property was revealed, and this property is expected to be the “magic number 13” metal cluster template.
Quality improvement programme, focusing on error reduction: a single center naturalistic study
Authors: Rosser David , Cowley Nicholas J , Ray Daniel , Nightingale Peter G , Jones Tim , Moore Julie , Coleman Jamie J 
Published: July 2012

Objectives Interventions to drive quality of care using strategies to empower clinical staff with personal and local performance indicators should lead to measurable improvements in outcome. The current evidence for the linkage of quality metrics and patient outcome usually relies on surrogate measures. There is a continuing need for the development of specific measurable indicators of quality of care, which have demonstrable links to patient outcome. Design A single centre naturalistic study to validate electronically collected drug administration and documentation measures of quality improvement, during the introduction of a quality improvement programme. Setting A large academic teaching hospital in the UK. Participants Staff involved in administration of prescribed medication using an in-house developed prescribing information and communication system (PICS). Main outcome measures Mortality data from nationally collected ‘hospital episode statistics’ and markers of the precision of medicines administration and documentation ‘uncharted’ and ‘missed’ drug doses. Results A 16.2% reduction in local mortality rate was demonstrated ( P=0.013) compared to static mortality rates throughout England. Similar temporal reductions were seen in the rates of missed and uncharted doses of medication at the hospital over the same period. Conclusions When monitored as part of a quality improvement strategy, ‘missed’ and ‘uncharted’ drug dose information may reflect wider institutional changes and act as a valid indicator of quality of healthcare more generally.
The development of one-stop wide-awake dupuytren's fasciectomy service: a retrospective review
Authors: Bismil Qmk , Bismil Msk , Bismil Annamma , Neathey Julia , Gadd Judith , Roberts Sue , Brewster Jennifer 
Published: July 2012

Objectives To detail the transition to a totally one-stop wide-awake (OSWA) Dupuytren's contracture surgical service. Design Retrospective review of Dupuytren's component of last 1000 OSWA cases. Setting The UK's first totally one-stop wide-awake orthopaedic service. Participants 270 patients with Dupuytren's contracture out of the last 1000 OSWA cases. Main outcome measures Surgical outcomes, patient satisfaction and cost-effectiveness and efficiency. Results The OSWA Dupuytren's model is safe, efficient and effective; with a low complication rate, extremely high patient satisfaction; and cost-savings to the nhs of £2500 per case treated. The service saved the NHS approximately £675,000 for the 270 cases presented. Conclusions A totally one-stop wide-awake Dupuytren's Contracture service is practicable and feasible alternative to the conventional treatment pathway, with benefits in terms of efficiency and cost-effectiveness.
Selling to Conspicuous Consumers: Pricing, Production, and Sourcing Decisions
Authors: Tereyağoğlu Necati , Veeraraghavan Senthil 
Published: July 2012

Consumers often purchase goods that are “hard to find” to conspicuously display their exclusivity and social status. Firms that produce such conspicuously consumed goods such as designer apparel, fashion goods, jewelry, etc., often face challenges in making optimal pricing and production decisions. Such firms are confronted with precipitous trade-off between high sales volume and high margins, because of the highly uncertain market demand, strategic consumer behavior, and the display of conspicuous consumption. In this paper, we propose a model that addresses pricing and production decisions for a firm, using the rational expectations framework. We show that, in equilibrium, firms may offer high availability of goods despite the presence of conspicuous consumption. We show that scarcity strategies are harder to adopt as demand variability increases, and we provide conditions under which scarcity strategies could be successfully adopted to improve profits. Finally, to credibly commit to scarcity strategy, we show that firms can adopt sourcing strategies, such as sourcing from an expensive production location/supplier or using expensive raw materials. This paper was accepted by Preyas Desai and Pradeep Chintagunta, marketing.
Estimating Allele Age and Selection Coefficient from Time-Serial Data
Authors: Malaspinas Anna-Sapfo , Malaspinas Orestis , Evans Steven N , Slatkin Montgomery 
Published: July 2012

AbstractRecent advances in sequencing technologies have made available an ever-increasing amount of ancient genomic data. In particular, it is now possible to target specific single nucleotide polymorphisms in several samples at different time points. Such time-series data are also available in the context of experimental or viral evolution. Time-series data should allow for a more precise inference of population genetic parameters and to test hypotheses about the recent action of natural selection. In this manuscript, we develop a likelihood method to jointly estimate the selection coefficient and the age of an allele from time-serial data. Our method can be used for allele frequencies sampled from a single diallelic locus. The transition probabilities are calculated by approximating the standard diffusion equation of the Wright–Fisher model with a one-step process. We show that our method produces unbiased estimates. The accuracy of the method is tested via simulations. Finally, the utility of the method is illustrated with an application to several loci encoding coat color in horses, a pattern that has previously been linked with domestication. Importantly, given our ability to estimate the age of the allele, it is possible to gain traction on the important problem of distinguishing selection on new mutations from selection on standing variation. In this coat color example for instance, we estimate the age of this allele, which is found to predate domestication.
Cellular Memory of Acquired Stress Resistance inSaccharomyces cerevisiae
Authors: Guan Qiaoning , Haroon Suraiya , Bravo Diego González , Will Jessica L , Gasch Audrey P 
Published: July 2012

AbstractCellular memory of past experiences has been observed in several organisms and across a variety of experiences, including bacteria “remembering” prior nutritional status and amoeba “learning” to anticipate future environmental conditions. Here, we show that Saccharomyces cerevisiae maintains a multifaceted memory of prior stress exposure. We previously demonstrated that yeast cells exposed to a mild dose of salt acquire subsequent tolerance to severe doses of H2O2. We set out to characterize the retention of acquired tolerance and in the process uncovered two distinct aspects of cellular memory. First, we found that H2O2 resistance persisted for four to five generations after cells were removed from the prior salt treatment and was transmitted to daughter cells that never directly experienced the pretreatment. Maintenance of this memory did not require nascent protein synthesis after the initial salt pretreatment, but rather required long-lived cytosolic catalase Ctt1p that was synthesized during salt exposure and then distributed to daughter cells during subsequent cell divisions. In addition to and separable from the memory of H2O2 resistance, these cells also displayed a faster gene-expression response to subsequent stress at &gt;1000 genes, representing transcriptional memory. The faster gene-expression response requires the nuclear pore component Nup42p and serves an important function by facilitating faster reacquisition of H2O2 tolerance after a second cycle of salt exposure. Memory of prior stress exposure likely provides a significant advantage to microbial populations living in ever-changing environments.
Financial Reporting Outcomes under Rules-Based and Principles-Based Accounting Standards
Authors: Collins Denton L. , Pasewark William R. , Riley Mark E. 
Published: July 2012

SYNOPSIS:
This archival study addresses whether the presence or absence of “bright lines” in a lease accounting standard influences the classification of leases as capital or operating. To the best of our knowledge, our study is the first archival research to address the association between lease classification decisions and the use of U.S. GAAP and IFRS lease accounting standards. We examine firms' lease classification decisions using 2007–2009 data from a matched sample of members of the Fortune Global 500 that report under U.S. GAAP and IFRS. Consistent with experimental work by Agoglia et al. (2011), we find strong evidence that U.S. GAAP firms using a lease standard containing bright-line guidance (i.e., ASC 840) are more likely to classify leases as operating than IFRS firms adhering to a lease accounting standard that lacks the bright lines of the U.S. standard (i.e., IAS 17). Also consistent with Agoglia et al. (2011), we find little evidence of increased dispersion accompanying financial reporting under IFRS. In fact, we find some evidence suggesting the use of IFRS may actually lead to lower dispersion in reporting outcomes.
CEO Age and Financial Reporting Quality
Authors: Huang Hua-Wei , Rose-Green Ena , Lee Chih-Chen 
Published: July 2012

SYNOPSIS:
This study examines the association between chief executive officer (CEO) age and the financial reporting quality of firms. The financial reporting qualities examined are the meeting or beating of analyst earnings forecasts and financial restatements. Based on extant research, we hypothesize that older CEOs are associated with higher-quality financial reporting. Using a sample of 3,413 firms for the period 2005 to 2008, we find a positive association between CEO age and financial reporting quality. Specifically, we find that CEO age is negatively associated with firms meeting or beating analyst earnings forecasts and financial restatements. Our study therefore extends the corporate governance and financial reporting quality literature by identifying CEO age as a determinant of financial reporting quality.
Data Availability: Data are publicly available.