bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penicillin Allergy Testing and Delabeling for Patients Who Are Prescribed Penicillin: A Systematic Review for a World Health Organization Guideline
Authors: Providencia Rui , Aali Ghazaleh , Zhu Fang , Leas Brian F. , Orrell Rachel , Ahmad Mahmood , Bray Jonathan J. H. , Pelone Ferruccio , Nass Petra , Marijon Eloi , Cassandra Miryan , Celermajer David S. , Shokraneh Farhad 
Published: May 2024

AbstractSecondary prevention with penicillin aims to prevent further episodes of acute rheumatic fever and subsequent development of rheumatic heart disease (RHD). Penicillin allergy, self-reported by 10% of the population, can affect secondary prevention programs. We aimed to assess the role for (i) routine penicillin allergy testing and the (ii) safety of penicillin allergy delabeling approaches in this context. We searched MEDLINE, Embase, CENTRAL, ClinicalTrials.gov, WHO ICTRP, ISRCTN, and CPCI-S to identify the relevant reports. We found 2419 records, but no studies addressed our initial question. Following advice from the WHO-Guideline committee and experts, we identified 6 manuscripts on allergy testing focusing on other populations showing that the prevalence of allergy confirmed by testing was low and the incidence of life-threatening reactions to BPG was very low (< 1–3/1000 individuals treated). A subsequent search addressed penicillin allergy delabeling. This found 516 records, and 5 studies addressing the safety of direct oral drug challenge vs. skin testing followed by drug administration in patients with suspected penicillin allergy. Immediate allergic reactions of minor severity were observed for a minority of patients and occurred less frequently in the direct drug challenge group: 2.3% vs. 11.5%; RR = 0.25, 95%CI 0.15–0.45, P < 0.00001, I2 = 0%. No anaphylaxis or deaths were observed. Severe allergic reactions to penicillin are extremely rare and can be recognized and dealt by trained healthcare workers. Confirmation of penicillin allergy diagnosis or delabeling using direct oral drug challenge or penicillin skin testing seems to be safe and is associated with a low rate of adverse reactions.
Predicting factors and clinical outcome of biochemical incomplete response in middle eastern differentiated thyroid carcinoma
Authors: Parvathareddy Sandeep Kumar , Siraj Abdul K. , Ahmed Saeeda O. , Annaiyappanaidu Padmanaban , Al-Rasheed Maha , Al-Haqawi Wael , Qadri Zeeshan , Al-Sobhi Saif S. , Al-Dayel Fouad , Al-Kuraya Khawla S. 
Published: May 2024

Abstract
Purpose
The aim of this study was evaluate biochemical incomplete response (BIR) in Middle Eastern differentiated thyroid cancer (DTC), identify factors that could predict BIR before radioactive iodine (RAI) ablation and to investigate the long-term clinical outcome of DTC patient exhibiting BIR to initial therapy.

Methods
We retrospectively evaluated 1286 DTCs from Middle Eastern ethnicity who underwent total thyroidectomy and RAI therapy. Demograpic and clinico-pathological factors predicting BIR were evaluated. The outcome of these patients was analyzed using primary outcome of structural disease and disease-free survival (DFS).

Results
With a median follow-up of 10 years, 266 (20.7%) patients had BIR. High pre-ablation stimulated thyroglobulin (presTg), presence of lymph node metastasis, male gender and delayed initial RAI therapy (≥3 months) after thyroidectomy were significant independent predictors of BIR. Upon evaluating long-term clinical outcomes in 266 patients with BIR, we found 36.8% of patients developed structural disease. Male sex (OR = 1.56; 95% CI = 1.05–2.30; p = 0.0272) and increasing Tg after initial therapy (OR = 4.25; 95% CI = 1.93–10.82; p = 0.0001) were independent risk factors for structural disease in patients with BIR. DFS was significantly worse if both these risk factors existed concomitantly (p < 0.0001).

Conclusion
To achieve the fair efficacy of RAI therapy, early prediction of BIR before RAI ablation is desirable. Our finding of the clinico-pathological factors (high presTg level, LNM, delayed RAI therapy and male gender) could serve as easy and robust early predictors of BIR. In addition, DTC patients exhibiting BIR had a high risk of structural disease and hence personalized management approach would be preferable for BIR patients to ensure best clinical outcome.
Discovering the hierarchical structure of variables describing adult attachment: insight from a joint analysis of seven questionnaires
Authors: Pietrzak Magdalena , Cieciuch Jan 
Published: May 2024

AbstractOur work aimed to discover the structure of variables developed to conceptualize attachment dimensions in seven main approaches and measurement instruments. A group of 435 participants (49.7% female, 46.2% male, 4.1% non-binary/other identities) between the ages of 16 and 65 (M = 24.8, SD = 8.1) completed a series of seven questionnaires commonly used to measure attachment. A series of exploratory factor analyses was performed on the scales and items. In the analysis on the scales, the two-factor structure of Anxiety and Avoidance was reproduced. In the analysis on the items, a meaningful hierarchical six-level structure was discovered. Dimensions of Anxiety and Avoidance are quite similar across models, but Avoidance is much more complex than Anxiety. Anxiety remains in principle the same across all levels of the hierarchy, while Avoidance divides into several lower-order traits. The lower-order traits of Avoidance need reconceptualization, and the current study takes a step in this direction.
A glimpse into the diversity of Colombian Acanthaceae
Authors: Wood John R. I. , Hoyos-Gómez Saúl E. , Zarate David E. Granados 
Published: May 2024

SummaryA short visit to four Colombian herbaria in 2022 is highlighted as an example of modern-day herbarium plant hunting which resulted in the discovery of 14 new species: Aphelandra guacharorum J.R.I.Wood, A. montis-tusae J.R.I.Wood & Hoyos-Gómez, Justicia betancurii J.R.I.Wood, J. chloroleuca J.R.I.Wood, J. cristalina J.R.I.Wood & Hoyos-Gómez, J. daironcardenasii J.R.I.Wood & Hoyos-Gómez, J. ipanorensis J.R.I.Wood, J. lutescens J.R.I.Wood & Hoyos-Gómez, J. macuirensis J.R.I.Wood, J. perijaensis J.R.I.Wood, J. reniformis J.R.I.Wood, J. rheophytica J.R.I.Wood & Hoyos-Gómez J. santanderana J.R.I.Wood & Hoyos-Gómez and Ruellia rheophytica J.R.I.Wood & Hoyos-Gómez. These are described and illustrated with line drawings. Additionally, a full description and line drawings of two poorly known species, Justicia hochreutineri J.F.Macbr. and J. trianae (Leonard) J.R.I.Wood are provided. Notes are provided on 21 other species drawing attention to new records for Colombia, rediscoveries and taxonomic issues. Justicia hochreutineri J.F.Macbr., J. pilosa (Ruiz ex Nees) Lindau, J. zamorensis Wassh. and Stenostephanus lasiostachyus Nees are recorded for the first time for Colombia. Justicia pampolystachys Leonard is treated as a synonym of J. hyperdasya Leonard. Poikilacanthus moritzianus (Nees) Lindau is shown to be restricted to Venezuela. Adhatoda pilosa Ruiz ex Nees is lectotypified. Attention is drawn to the number of rheophytes in Colombian Acanthaceae and to the importance of the Río Claro and Río Samaná Norte area of Antioquia as a centre of plant diversity.
Partnering with Schools to Adapt a Team Science Intervention: Processes and Challenges
Authors: Kuriyan Aparajita Biswas , Albright Jordan , Rushworth Samantha , Duresso Biiftu , Testa Shannon , Eiraldi Ricardo B. , Marshaleck Edward W. , Wolk Courtney Benjamin 
Published: May 2024

AbstractPublic schools are a major provider of mental health services for children in the US. Mental and behavioral health services range from universal programming to individualized clinical supports to address student needs. These services in schools are delivered by various professionals including non-teaching and teaching school personnel, school-employed clinicians, and/or contracted community mental health partners. Provision of mental health services requires complex coordination of providers across disciplines, although few professionals have training in multidisciplinary collaboration strategies. Attention to team processes, such as delineating team members' roles, improving communication, and identifying collaboration strategies, may impact the effectiveness of evidence-based mental health service provision in real world settings. One intervention, Team Strategies and Tools to Enhance Performance and Patient Safety (TeamSTEPPS), has been used in healthcare with positive outcomes and has been adapted to educational settings. The current paper describes the community-partnered subsequent adaptation of TeamSTEPPS for schools. Needs assessment interviews identified challenges, successes, and goals for student mental health. Overarching themes extracted from interviews include limited resources at multiple levels (e.g., financial support, time, and personnel), communication challenges, and poor role clarity. A community advisory board provided guidance during the adaptation and implementation planning process. Adaptations to the intervention included tailoring the intervention to the school context and the development of flexible training plans. In addition, individualized implementation plans were developed with each school partner to mitigate foreseeable barriers to rolling-out TeamSTEPPS. Our team is currently piloting the adapted TeamSTEPPS intervention and implementation strategies in partnership with three school districts.
Hadron therapy in radiation oncology and why BNCT is a paradigm shift
Authors: Sauerwein Wolfgang A. G. , Igawa Kazuyo , Herault Joël , Fossati Piero , Altieri Saverio , Moss Raymond L. , Wittig Andrea 
Published: May 2024

Abstract
Purpose
Hadrons, i.e. particles that are heavier than electrons, are playing an increasingly important role in radiation oncology. Due to the high investment costs for the necessary infrastructure, this option is only available in specialized centers.

Methods
This article describes some of the physical properties that make hadrons attractive for external beam radiation therapy (EBRT), but also some of the challenges that need to be considered.

Results
The importance of linear energy transfer for biological effects is discussed.

Conclusions
In addition to the use of charged particles, the importance of neutrons for radiotherapy is also highlighted, in particular the properties of boron neutron capture therapy (BNCT), which open up completely new possibilities for the further development of EBRT.
A Pilot Study of Aerosolization of Infectious Murine Norovirus in an Experimental Setup
Authors: Purhonen Roderik , Atanasova Nina S. , Salokas Julija , Duplissy Jonathan , Loikkanen Emil , Maunula Leena 
Published: May 2024

AbstractHuman norovirus is transmitted mainly via the faecal-oral route, but norovirus disease outbreaks have been reported in which airborne transmission has been suggested as the only explanation. We used murine norovirus (MNV) as a surrogate for human norovirus to determine the aerosolization of infectious norovirus in an experimental setup. A 3-l air chamber system was used for aerosolization of MNV. Virus in solution (6 log10 TCID50/ml) was introduced into the nebulizer for generating aerosols and a RAW 264.7 cell dish without a lid was placed in the air chamber. Cell culture medium samples were taken from the dishes after the aerosol exposure time of 30 or 90 min, and the dishes were placed in a 37 °C, 5% CO2 incubator and inspected with a light microscope for viral cytopathic effects (CPEs). We determined both the infectious MNV TCID50 titre and used an RT-qPCR assay. During the experiments, virus infectivity remained stable for 30 and 90 min in the MNV solution in the nebulizer. Infectious MNV TCID50 values/ml of 2.89 ± 0.29 and 3.20 ± 0.49 log10 were measured in the chamber in RAW 264.7 cell dish media after the 30-min and 90-min exposure, respectively. The MNV RNA loads were 6.20 ± 0.24 and 6.93 ± 1.02 log10 genome copies/ml, respectively. Later, a typical MNV CPE appeared in the aerosol-exposed RAW cell dishes. We demonstrated that MNV was aerosolized and that it remained infectious in the experimental setup used. Further studies required for understanding the behaviour of MNV in aerosols can thus be performed.
Food security and livelihoods in protracted crisis: the experience of rural residents in Syria’s war zones
Authors: Ibrahim Kindah , Bavorova Miroslava , Zhllima Edvin 
Published: May 2024

AbstractFood insecurity is an increasingly pressing and grave issue in contemporary Syria. The ongoing crisis has severely affected agriculture in a country which used to be food-producing and self-sufficient. This study addresses the factors that impact household-level food security in Syria. Our analysis is based on 1,381 household surveys using a structured questionnaire in 12 governorates of the country. We followed a two-stage least square regression (2SLS) approach to analyse the interconnected factors of food security. We use three different indicators to capture different dimensions of food security: the Food Consumption Score (FCS), the Dietary Diversity Score (DDS), and the Reduced Coping Strategy Index (rCSI). Our findings underscore the vital role of aid programs and post-crisis remedial assistance in bolstering farmers' resilience and enhancing their food security. Despite adverse constraints generated by the prolonged crisis, continued reliance on agricultural activities continued having a positive contribution to food security. Female-headed households experience higher food insecurity than their male-headed counterparts (MHHs). However, Female-headed households excel in nutritional diversity. Both results should be approached carefully due to data limitations. Addressing the repercussions of conflict-induced food insecurity requires mitigating the effects of the proximity of conflict zones and reducing disruptions in food value chains. Future research should consider how food security relates to gender and intra-household gender inequalities during protracted crises.
Assessment of meteorological, hydrological and groundwater drought in the Konya closed basin, Türkiye
Authors: Kartal Veysi , Nones Michael 
Published: May 2024

AbstractWater scarcity, and drought in particular, is a major challenge worldwide, causing direct and indirect negative effects on ecological systems and water resources, as well as social and economic aspects of life. Climate change and increasing human pressure are contributing to increasing the likelihood of droughts, impacting regions which were not used to be dry. To address this challenge properly, studies should be performed at a multi-scale level, addressing hydrological and hydrogeological drought. Focusing on the Konya Closed Basin in Türkiye, data derived from nineteen stations were used to analyze drought conditions, looking at multiple meteorological—Standardized Precipitation Index (SPI), Z Score Index (ZSI), China Z Index (CZI), Modified China Z Index (MCZI)—hydrological—Streamflow Drought Index (SDI), Surface Water Supply Index (SWSI)—and hydrogeological—Standardized Groundwater Level Index (SGI)—assessment indices for different time scales (1, 3, 6,12, 24, 36 and 48 months). The results show that extreme drought (ED) conditions computed by SPI at 1 month (1.9–2.5%) were higher than that of all indices for all stations. Moderate drought occurred at least according to the ZSI-1. It was determined that the percentage of SPI and CZI had greater Extremely, Severely and Moderately Dry events (10.7–13.4% for CZI; 10.7–14.2% for SPI) than those of ZSI and MCZI. On the other part, MCZI has shown fewer total drought events (6.2–10%). Since 2008, extremely dry conditions in the Konya Closed Basin are generally caused by groundwater drought, which is higher than meteorological and hydrological droughts. The results reported in this work might help in better planning drought-resilient strategies in the basin, which will be paramount in light of climate change.
A cuproptosis-related signature predicts prognosis and indicates cross-talk with immunocyte in ovarian cancer
Authors: Yang Bikang , Yang Juan , Zhang Keqiang 
Published: May 2024

Abstract
Purpose
Cuproptosis, programmed cell death by intracellular copper-mediated lipoylated protein aggregation, is involved in various tumorigenesis and drug resistance abilities by mediating the tumor microenvironment. Previous studies have demonstrated that serum copper levels are higher in OC patients than in normal subjects. However, the exact relationship between cuproptosis and ovarian cancer progression remains to be further elucidated.

Methods
The Cancer Genome Atlas (TCGA) and gene expression omnibus (GEO) datasets were utilized to establish a cuproptosis-related prognostic signature in ovarian cancer. Subsequently, the bulk RNA-seq analysis and single-cell RNA-seq analysis were used to identify the relationship between signature with immune cell infiltration, chemotherapy, and cuproptosis-related scoring (CuRS) system. Finally, the potential biological functional roles of target genes in cuproptosis were validated in vitro.

Results
By using LASSO-Cox regression analysis to establish the cuproptosis-related prognostic model, our works demonstrated the accuracy and efficiency of our model in the TCGA (583 OC patients) and GEO (260 OC patients) OC cohorts, and the high-scoring groups showed worse survival outcomes. Notably, there were substantial differences between the high and low-risk groups in extensive respects, such as the activating transcription factors, cell pseudotime features, cell intercommunication patterns, immunocytes infiltration, chemotherapy response, and potential drug resistance. KIF26B was selected to construct a prognostic model from the identified 33 prognosis-related genes, and high expression of KIF26B predicted poorer prognosis in ovarian cancer. Ultimately, further in vitro experiments demonstrated that KIF26B participated in the proliferation and cisplatin resistance of OC cells. Knockdown of KIF26B increased the sensitivity of OC cells to elesclomol, a cuproptosis agonists.

Conclusion
This study constructed a new cuproptosis-related gene signature that has a good prognostic capacity in assessing the outcome of OC patients. This study enhances our understanding of cuproptosis associated with ovarian cancer aggressiveness, cross-talk with immunocytes, and serves as a novel chemotherapy strategy.
Clinical Performance Evaluation of an Artificial Intelligence-Powered Amyloid Brain PET Quantification Method
Authors: Kang Seung Kwan , Heo Mina , Chung Ji Yeon , Kim Daewoon , Shin Seong A. , Choi Hongyoon , Chung Ari , Ha Jung-Min , Kim Hoowon , Lee Jae Sung 
Published: May 2024

Abstract
Purpose
This study assesses the clinical performance of BTXBrain-Amyloid, an artificial intelligence-powered software for quantifying amyloid uptake in brain PET images.

Methods
150 amyloid brain PET images were visually assessed by experts and categorized as negative and positive. Standardized uptake value ratio (SUVR) was calculated with cerebellum grey matter as the reference region, and receiver operating characteristic (ROC) and precision-recall (PR) analysis for BTXBrain-Amyloid were conducted. For comparison, same image processing and analysis was performed using Statistical Parametric Mapping (SPM) program. In addition, to evaluate the spatial normalization (SN) performance, mutual information (MI) between MRI template and spatially normalized PET images was calculated and SPM group analysis was conducted.

Results
Both BTXBrain and SPM methods discriminated between negative and positive groups. However, BTXBrain exhibited lower SUVR standard deviation (0.06 and 0.21 for negative and positive, respectively) than SPM method (0.11 and 0.25). In ROC analysis, BTXBrain had an AUC of 0.979, compared to 0.959 for SPM, while PR curves showed an AUC of 0.983 for BTXBrain and 0.949 for SPM. At the optimal cut-off, the sensitivity and specificity were 0.983 and 0.921 for BTXBrain and 0.917 and 0.921 for SPM12, respectively. MI evaluation also favored BTXBrain (0.848 vs. 0.823), indicating improved SN. In SPM group analysis, BTXBrain exhibited higher sensitivity in detecting basal ganglia differences between negative and positive groups.

Conclusion
BTXBrain-Amyloid outperformed SPM in clinical performance evaluation, also demonstrating superior SN and improved detection of deep brain differences. These results suggest the potential of BTXBrain-Amyloid as a valuable tool for clinical amyloid PET image evaluation.
Active afforestation of drained peatlands is not a viable option under the EU Nature Restoration Law
Authors: Jurasinski Gerald , Barthelmes Alexandra , Byrne Kenneth A. , Chojnicki Bogdan H. , Christiansen Jesper Riis , Decleer Kris , Fritz Christian , Günther Anke Beate , Huth Vytas , Joosten Hans , Juszczak Radosław , Juutinen Sari , Kasimir Åsa , Klemedtsson Leif , Koebsch Franziska , Kotowski Wiktor , Kull Ain , Lamentowicz Mariusz , Lindgren Amelie , Lindsay Richard , Linkevičienė Rita , Lohila Annalea , Mander Ülo , Manton Michael , Minkkinen Kari , Peters Jan , Renou-Wilson Florence , Sendžikaitė Jūratė , Šimanauskienė Rasa , Taminskas Julius , Tanneberger Franziska , Tegetmeyer Cosima , van Diggelen Rudy , Vasander Harri , Wilson David , Zableckis Nerijus , Zak Dominik H. , Couwenberg John 
Published: May 2024

AbstractThe EU Nature Restoration Law (NRL) is critical for the restoration of degraded ecosystems and active afforestation of degraded peatlands has been suggested as a restoration measure under the NRL. Here, we discuss the current state of scientific evidence on the climate mitigation effects of peatlands under forestry. Afforestation of drained peatlands without restoring their hydrology does not fully restore ecosystem functions. Evidence on long-term climate benefits is lacking and it is unclear whether CO2 sequestration of forest on drained peatland can offset the carbon loss from the peat over the long-term. While afforestation may offer short-term gains in certain cases, it compromises the sustainability of peatland carbon storage. Thus, active afforestation of drained peatlands is not a viable option for climate mitigation under the EU Nature Restoration Law and might even impede future rewetting/restoration efforts. Instead, restoring hydrological conditions through rewetting is crucial for effective peatland restoration.