bluuebunny/crossref_metadata_2025_split huggingface dataset:
ciRS‐7 circular RNA overexpression in plasma cells is a promising molecular biomarker of unfavorable prognosis in multiple myeloma
Authors: Papatsirou Maria , Kontos Christos K. , Ntanasis‐Stathopoulos Ioannis , Malandrakis Panagiotis , Theodorakakou Foteini , Liacos Christine‐Ivy , Mavrianou‐Koutsoukou Nefeli , Fotiou Despina , Migkou Magdalini , Gavriatopoulou Maria , Kastritis Efstathios , Dimopoulos Meletios A. , Scorilas Andreas , Terpos Evangelos 
Published: June 2024

AbstractSeveral non‐coding RNAs are known to be associated with the pathobiology and progression of multiple myeloma (MM). ciRS‐7 (also known as CDR1‐AS), a key oncogenic circular RNA (circRNA) that sponges miR‐7‐5p and other cancer‐related microRNAs, was recently found to be downregulated in malignant plasma cells resistant to immunomodulatory drugs. Considering that various circRNAs have a strong potential as molecular biomarkers, we aimed to investigate the expression of ciRS‐7 in plasma cell disorders, assess its prognostic importance in MM, and compare these findings with those of individuals with smoldering MM (SMM) and monoclonal gammopathy of unknown significance (MGUS). This study included 171 patients (110 newly diagnosed MM, 34 SMM, and 27 MGUS cases), from which bone marrow aspirate samples were collected for CD138+ plasma cell selection. Total RNA was reversely transcribed using random hexamer primers, and the expression levels of ciRS‐7 were quantified using an in‐house‐developed protocol that includes pre‐amplification and real‐time quantitative polymerase chain reaction. ciRS‐7 levels were found to significantly differ among CD138+ plasma cells of MM, SMM, and MGUS patients. ROC analysis indicated that ciRS‐7 expression effectively distinguishes between MM and SMM patients. Moreover, high levels of ciRS‐7 were associated with unfavorable prognosis in MM, independently of MM patients’ age and Revised International Staging System stage. Additionally, in silico analysis predicted the binding of 85 microRNAs to ciRS‐7. In conclusion, this study provides novel insights into the role of ciRS‐7 as a promising molecular marker able to distinguish MM from SMM and predict prognosis in MM.
Design and application of optimum toroidal shaped electromagnetic energy harvesters for unmanned aerial vehicles
Authors: Balcı M. Şamil , Dalcalı Adem 
Published: June 2024

AbstractThis study presents the design and implementation of electromagnetic energy harvesters for the purpose of charging unmanned aerial vehicles (UAVs) battery. In the study, the designed harvesters are analyzed through finite element method (FEM) simulations. In the FEM analysis, common and self‐inductance values, as well as magnetic flux density values of the harvesters, are calculated at specific current values. Inductance values are also theoretically calculated for comparison. Subsequently, an experimental setup is established to test the designed harvesters. After winding the core, the induced voltage and the power transferred to the load by the harvesters are measured. Curve fitting is performed after the measurements with different load resistances to find the maximum power transferred to the load. Through curve fitting, the maximum power obtained at each current value and at which load resistance this power is harvested are determined. Considering the intention of using the designed cores to charge UAVs and the importance of weight in UAV flight, the weights of each core, both without winding and after winding, are measured, and their costs are calculated. Taking all these criteria into account, the performance of the harvesters is demonstrated, and those among the used cores that are the most suitable for UAVs are identified in the study.
The Relationship Between Attitudes Toward Authority and Innovative Behavior in Adolescents: The Mediating Roles of Social Support and Perspective Taking
Authors: Chang Chu‐Yang , Kuo Hsu‐Chan 
Published: June 2024

ABSTRACTParents and teachers are significant authority figures that substantially impact adolescents' psychological and cognitive development, including their creativity. The current study investigated the relationship between adolescents' attitudes toward authority (parents and teachers) and innovative behavior and examined the mediating effects of social support and perspective taking. According to attachment theory, adolescents' attitudes toward authority may derive from early interaction with primary caregivers, primarily parents. Individuals internalize these interaction experiences and form internal working models, which will be applied in later life stages when interacting with authority figures. These early life experiences also influence individuals' sense of support and empathy abilities. Through analyzing a sample comprising 1,498 adolescents from Taiwan, this study unveils a significant association between adolescents' perceptions of authority and their proclivity for innovative conduct, as well as their levels of social support and capacity for perspective taking. Employing structural equation modeling (SEM), the empirical findings accentuate the mediating role of social support and perspective taking in delineating the nexus between adolescents' attitude toward authority and their manifestation of innovative behavior. The results revealed that adolescents with positive attitudes toward authority are likely to sense support, stand from other viewpoints, and further benefit creativity.
Manipulation of Upconversion Luminescence in Heavily Lanthanide‐Doped Halide Double Perovskites for Optical Information Storage
Authors: Tang Baoling , Zhou Xinquan , Li Tianrui , Li Liang , Zhang Haoran , Molokeev Maxim , Golovnev Nicolay , Xia Zhiguo , Lei Bingfu 
Published: June 2024

AbstractUpconversion (UC) process involves diverse energy levels and photoluminescence modes, however, it faces the challenge of concentration quenching of the doped lanthanide ions with multiple luminescence centers. Herein, Yb3+/Ho3+ and Yb3+/Tm3+ are heavily codoped into the lead‐free halide double perovskite single crystal Cs2NaErCl6, enabling the controlled energy transfer UC process, and accordingly, the UC materials exhibit anti‐concentration‐quenching owing to the defect tolerance characters. Depending on different doping couples, the UC materials show green and red emissions under the 980 nm laser excitations. Moreover, the green‐to‐red emission ratio in Yb3+/Tm3+ codoped Cs2NaErCl6 changes dynamically with the increasing pumping intensity due to the different sensitivities of the excited energy levels. This study provides a renewed direction of the lanthanide ions heavily‐doped halide double perovskites toward UC materials and facilitates the development of new smart luminescence materials for optical information storage applications.
Structure and Dynamics of Ions in a Poly(ethylene oxide) Matrix Near a Graphite Surface
Authors: Balogun Adegbola , Khare Rajesh 
Published: June 2024

AbstractSolid polymer electrolytes are being explored as replacements for organic electrolytes in lithium‐ion batteries due to their less flammable nature and high mechanical strength. However, challenges remain, such as low ionic conductivity, and significant interfacial impedance with electrodes. Understanding the structure and dynamics of ions within polymer electrolytes and near the anode is crucial for enhancing battery performance and safety. In this study, the structural and dynamic properties of lithium cation (Li+) and bis(trifluoromethane sulfonyl)imide anion (TFSI−) in poly(ethylene oxide) matrix are examined in bulk PEO‐LiTFSI electrolyte and in the presence of a graphite surface using molecular dynamics simulations. The findings suggest that the presence of graphite surface does not affect the coordination of oxygen atoms around the Li+ ions. Results also show that the dynamics of the ions and ether oxygen is hindered near the graphite surface compared to the region away from the graphite surface.
Technical note: Characterization of a multi‐point scintillation dosimetry research platform for a low‐field MR‐Linac
Authors: Crosby Jennie , Ruff Chase , Gregg Ken , Turcotte Jonathan , Glide‐Hurst Carri 
Published: June 2024

AbstractBackgroundMRI‐guided radiation therapy (MRgRT) requires unique quality assurance equipment to address MR‐compatibility needs, minimize electron return effect, handle complex dose distributions, and evaluate real‐time dosimetry for gating. Plastic scintillation detectors (PSDs) are an attractive option to address these needs.PurposeTo perform a comprehensive characterization of a multi‐probe PSD system in a low‐field 0.35 T MR‐linac, including detector response assessment and gating performance.MethodsA four‐channel PSD system (HYPERSCINT RP‐200) was assembled. A single channel was used to evaluate repeatability, percent depth dose (PDD), detector response as a function of orientation with respect to the magnetic field, and intersession variability. All four channels were used to evaluate repeatability, linearity, and output factors. The four PSDs were integrated into an MR‐compatible motion phantom at isocenter and in gradient regions. Experiments were conducted to evaluate gating performance and tracking efficacy.ResultsFor repeatability, the maximum standard deviation of repeated measurements was 0.13% (single PSD). Comparing the PSD to reference data, PDD had a maximum difference of 1.12% (10 cm depth, 6.64 × 6.64 cm2). Percent differences for rotated detector setups were negligible (< 0.3%). All four PSDs demonstrated linear response over 10–1000 MU delivered and the maximum percent difference between the baseline and measured output factors was 0.78% (2.49 × 2.49 cm2). Gating experiments had 400 cGy delivered to isocenter with < 0.8 cGy variation for central axis measures and < 0.7 cGy for the gradient sampled region. Real‐time dosimetry measurements captured spurious beam‐on incidents that correlated to tracking algorithm inaccuracies and highlighted gating parameter impact on delivery efficiency.ConclusionsCharacterization of the multi‐point PSD dosimetry system in a 0.35 T MR‐linac demonstrated reliability in a low‐field MR‐Linac setting, with high repeatability, linearity, small intersession variability, and similarity to baseline data for PDD and output factors. Time‐resolved, multi‐point dosimetry also showed considerable promise for gated MR‐Linac applications.
Associations and outcomes of prenatally detected rhombencephalosynapsis
Authors: Kunpalin Yada , Miller Elka , Raghuram Kamini , Shannon Patrick , Fisher Yael , Chau Vann , Toi Ants , Chitayat David , Blaser Susan , Shinar Shiri 
Published: June 2024

AbstractObjectiveTo describe the association between prenatal imaging and neurodevelopmental outcomes of fetuses with rhombencephalosynapsis (RES).Study designThirty‐four pregnancies complicated by RES were identified from our institutional databases based on US and/or MRI findings. Genetic testing results were gathered. In cases of termination of pregnancy, we studied the association between prenatal imaging and neuropathologic findings. For those who opted for expectant management, comprehensive developmental assessments and postnatal MRI imaging were evaluated.ResultsOver one third of fetuses in our cohort had complete RES. Common intracranial anomalies identified were mesencephalosynapsis, aqueduct stenosis and diencephalosynapsis. The degree of RES was not associated with the frequency of additional central nervous system anomalies. MRI had a good correlation with neuropathologic findings with regard to the degree of RES, aqueduct stenosis and mesencephalosynapsis. Postmortem autopsy showed that one third of our cases had VACTERL‐H and almost all of those had complete RES. All liveborn neonates(n = 6) had aqueduct stenosis requiring ventriculoperitoneal shunting within days of delivery (median 5 days). While a large proportion of prenatally suspected complete RES were found to have partial RES on postnatal imaging, prenatal diagnosis of aqueduct stenosis remained unchanged. All children that were at least 2 years old (n = 3) had global developmental delay.ConclusionPrenatal assessment of the RES severity is challenging and may be unreliable. Nevertheless, postnatal prognosis is poor for both complete and partial RES. Associated aqueductal stenosis, can be reliably assessed prenatally and this may contribute to worse postnatal prognosis than the degree of RES.
Flexible laser plastic welding as an addition to AM
Authors: Kroth Lea , Geiger René , Kopp Sebastian‐Paul , Tangermann‐Gerk Katja 
Published: June 2024

AbstractIndividualization, shorter product cycles and prototyping are leading to increased use of additive manufacturing in industry. A reliable and versatile process like laser plastic welding is needed to join parts with other additively manufactured or injection molded parts.
Citrus‐mediated gene silencing of cytochrome P450 suppresses insecticide resistance and increases mortality in Diaphorina citri
Authors: Kishk Abdelaziz , Stelinski Lukasz L. , Gowda Siddarame , Killiny Nabil 
Published: June 2024

AbstractBACKGROUNDAsian citrus psyllid, Diaphorina citri, is a hemipteran that vectors the causal pathogen of citrus greening disease, or huanglongbing (HLB). HLB is a tree killing disease that has severely limited citrus production globally. Unfortunately, there is no cure for this disease, and mitigation depends on multiple insecticide applications to reduce vector populations. Silencing of cytochrome P450 expression associated with detoxification enzymes by RNA interference is known to increase susceptibility of D. citri to insecticides. However, dsRNA was previously introduced into psyllids by topical applications. The possible application of this technology for pest management will require effective field delivery of the dsRNA. Therefore, we evaluated a virus vector (Citrus tristeza virus; ‘mild strain’ T36) to deliver gene silencing directly to this sap‐sucking insect via plant phloem. Citrus macrophylla plants inoculated with CTV expressing a truncated consensus sequence of CYP450 (CTV‐tCYP450) constantly produced small interfering RNA in the plant phloem that targeted five cytochrome p540 (CYP450) genes in D. citri.RESULTSInsecticide susceptible D. citri reared on citrus infected with CTV‐tCYP450 were subsequently more susceptible to imidacloprid, fenpropathrin, carbaryl, and chlorpyrifos than those reared on citrus infected with wildtype CTV or non‐infected negative controls. Additionally, nymph survival and adult lifespan were significantly reduced when psyllids were reared on CTV‐tCYP450 citrus plants compared with controls. Interestingly, similar results were obtained after one and two generations of rearing. Finally, field‐collected psyllids from areas with known broad‐spectrum insecticide resistance were rendered more susceptible to imidacloprid and fenpropathrin after feeding on CTV‐tCYP450 citrus trees as compared with those reared on controls.CONCLUSIONThe integration of citrus‐mediated RNA inference targeting psyllid detoxification enzymes could function as a resistance management tool and reduce insecticide input in an integrated pest management program for HLB. © 2024 Society of Chemical Industry.
Network intrusion detection system for IoT security using machine learning and statistical based hybrid feature selection
Authors: Walling Supongmen , Lodh Sibesh 
Published: June 2024

AbstractThe widespread adoption of Internet of Things (IoT) devices has revolutionized daily life, offering convenience and efficiency. However, this growth has also brought new security challenges. With the escalating use of Internet and network technology, the number of cyber‐attacks has increased, intensifying the focus on Intrusion Detection Systems (IDS) among researchers. Network intrusion detection (NID) plays a crucial role in securing IoT networks, becoming essential for modern security infrastructure. Recently, machine learning algorithms have shown promise in providing IDS solutions. Yet, IoT IDS systems face challenges due to their functional and physical diversity, making comprehensive feature utilization impractical. Therefore, effective feature selection becomes imperative. In this research, a novel feature selection methodology for anomaly‐based NIDS is proposed. The methodology commences by employing two filter‐based techniques, namely 1‐way ANOVA and the Pearson correlation coefficient, to meticulously identify and extract pertinent features from the dataset. These methods serve as initial filters to discern the most relevant attributes, ensuring that only the most informative features are retained for subsequent analysis. Subsequently, the most optimal features identified by both methodologies are extracted utilizing the principles of union and intersection in mathematical set theory. Using the NSL‐KDD and UNSW‐NB15 datasets, we exemplify how our model can outperform conventional ML classifiers in terms of detection rate, precision, recall. In our study, intrusion detection is carried out by SVM, kNN, Decision Tree, Logistic Regression and Random Forest using trained attack patterns. The demonstrated results highlight the exceptional performance of the proposed system, with an impressive accuracy rate of 99.6% on the NSL‐KDD dataset and a substantial 97.7% on the UNSW‐NB15 dataset, clearly surpassing the performance of contemporary methods.
Introduction
Authors: Boillet Véronique , Weerts Sophie , Ziegler Andreas R. 
Published: June 2024

AbstractAt the 1906 Olympic Games in Athens, the athlete Peter O’Connor protested the erasure of Ireland from the Olympics by climbing the flagpole during his medal ceremony, and replacing the Union Jack with the Irish flag. At the 1932 Olympic Games in Los Angeles, in the midst of the Great Depression, demonstrators denounced the economic injustice of the high cost of the Games. In 1968, at the Mexico City Olympics, Tommie Smith and John Carlos raised their fists in a Black Power salute when receiving their medals. More recently, the construction of infrastructure for the 2012 London Olympics and the 2016 Rio Olympics led to the displacement of marginalized communities, with the promise of access to new infrastructure, which has yet to materialize. Whether concerning particular athletes, people involved in the organization of sporting events, or other causes, these various protests at the Olympics throughout history prove that attacks on human dignity, individual freedom, and equality between individuals also echo in sport. From this perspective, the sporting environment is not disconnected from major contemporary social issues: it constitutes a public space in which injustices can be denounced, but also the theater in which prejudices are perpetuated against various parties, such as athletes or workers. The issue of Sport in the field of human rights has received little attention. However, several elements show that it is an issue that is becoming increasingly important, as demonstrated by the recent case law of the European Court of Human Rights and the development of the business and human rights approach in sports institutions. In this context, our book first aims to cover the issue of human rights in the field of Sport from the athletes' perspective. It considers that athletes are part of a specific category of human rights beneficiaries, which therefore deserves special attention from a theoretical and practical point of view. Second, it wants to inform athletes about human rights in their specific context.
Conceptualizing the Right to Sport: Why Should Trivial Participation in Sport Be Regarded as a Human Right?
Authors: Di Marco Antonio 
Published: June 2024

AbstractConsidering its extraordinary capacity to be a vehicle of rights, and to give meaning to reality, sport is among the most important trivial subjects in the world. Discriminated groups, which are denied (or substantially limited) access to the practice of sport, demand not only their right to participate in sporting activities but also the recognition of this claim as valid by society and public authorities. This chapter proposes the idea that expanding the catalogue of human rights, by including the right to sport, is supported by the existing body of international human rights law. It would reinforce the protection of human rights in sporting contexts by enhancing the unity of fragmented claims founded on a plurality of legal instruments. Taking into consideration the thesis that inclusive and non-discriminatory access to sporting activities would be an amalgamation of several treaty-based rights, the legal foundations of the right to sport are explained and evaluated. By verifying the legal relationship between access to sporting activities and sport’s social functions, the beneficiaries of such a right are investigated, and the obligations for national and sporting authorities are explored. By arguing that the right to pursue personal development would play a central role, while the right to health and education would be complementary, this chapter strives to answer the essential ethical question of why the trivial participation in sport should be considered an inherent right of the human being, cutting through the considerable confusion surrounding the right to sport.
#MeToo, Sport, and Women: Foul, Own Goal, or Touchdown? Online Abuse of Women in Sport as a Contemporary Issue
Authors: Barker Kim , Jurasz Olga 
Published: June 2024

AbstractOnline violence against women (OVAW), and online gender-based abuse more broadly, have been acknowledged at an international level as an obstacle to gender equality as well as women’s freedom of expression, positioning these phenomena as a concern from a human rights perspective. In particular, the scale, seriousness and the impact of social media abuse has raised questions about the appropriate legal protections for individuals from such forms of abuse and its harms. The world of sport has not been immune to the devasting impact of social media abuse, especially online hate, leading to a social media boycott within the British sport community in May 2021 as a protest against online hostility and discrimination. However, little action has been taken to date to address gender-based abuse and online misogyny directed at women in sport. Left unchecked and unaccounted for, instances of such online abuse reinforce the already existing structures and gender stereotypes that fuel gender-based hostility and violence against women. What is more, by being left unchallenged and allowed to play out in the very public context of professional sports, these behaviors become normalized, contributing to the continuum of violence against women, but doing so on a global and high-profile stage. While there have been controversial campaigns, such as taking the knee, there are few of any significance from the sporting world that address OVAW. Limited protections exist in terms of human rights, but little has been done by sporting bodies, sporting associations, and unions to add value to any initiatives aimed at tackling OVAW in sport. This chapter questions the role of sport in supporting the global action against violence against women, while also assessing the broader response to problems posed by online abuse, online harassment, and its gendered aspects. Do human rights protections go far enough? Is this an issue for sporting bodies, or is it an ‘athlete-only’ problem?