The single-cell opioid responses in the context of HIV (SCORCH) consortium
Authors: Ament Seth A. , Campbell Rianne R. , Lobo Mary Kay , Receveur Joseph P. , Agrawal Kriti , Borjabad Alejandra , Byrareddy Siddappa N. , Chang Linda , Clarke Declan , Emani Prashant , Gabuzda Dana , Gaulton Kyle J. , Giglio Michelle , Giorgi Federico M. , Gok Busra , Guda Chittibabu , Hadas Eran , Herb Brian R. , Hu Wen , Huttner Anita , Ishmam Mohammad R. , Jacobs Michelle M. , Kelschenbach Jennifer , Kim Dong-Wook , Lee Cheyu , Liu Shuhui , Liu Xiaokun , Madras Bertha K. , Mahurkar Anup A. , Mash Deborah C. , Mukamel Eran A. , Niu Meng , O’Connor Richard M. , Pagan Chelsea M. , Pang Alina P. S. , Pillai Piya , Repunte-Canonigo Vez , Ruzicka W. Brad , Stanley Jay , Tickle Timothy , Tsai Shang-Yi A. , Wang Allen , Wills Lauren , Wilson Alyssa M. , Wright Susan N. , Xu Siwei , Yang Junchen , Zand Maryam , Zhang Le , Zhang Jing , Akbarian Schahram , Buch Shilpa , Cheng Christine S. , Corley Michael J. , Fox Howard S. , Gerstein Mark , Gummuluru Suryaram , Heiman Myriam , Ho Ya-Chi , Kellis Manolis , Kenny Paul J. , Kluger Yuval , Milner Teresa A. , Moore David J. , Morgello Susan , Ndhlovu Lishomwa C. , Rana Tariq M. , Sanna Pietro Paolo , Satterlee John S. , Sestan Nenad , Spector Stephen A. , Spudich Serena , Tilgner Hagen U. , Volsky David J. , White Owen R. , Williams Dionne W. , Zeng Hongkui 
Published: June 2024

AbstractSubstance use disorders (SUD) and drug addiction are major threats to public health, impacting not only the millions of individuals struggling with SUD, but also surrounding families and communities. One of the seminal challenges in treating and studying addiction in human populations is the high prevalence of co-morbid conditions, including an increased risk of contracting a human immunodeficiency virus (HIV) infection. Of the ~15 million people who inject drugs globally, 17% are persons with HIV. Conversely, HIV is a risk factor for SUD because chronic pain syndromes, often encountered in persons with HIV, can lead to an increased use of opioid pain medications that in turn can increase the risk for opioid addiction. We hypothesize that SUD and HIV exert shared effects on brain cell types, including adaptations related to neuroplasticity, neurodegeneration, and neuroinflammation. Basic research is needed to refine our understanding of these affected cell types and adaptations. Studying the effects of SUD in the context of HIV at the single-cell level represents a compelling strategy to understand the reciprocal interactions among both conditions, made feasible by the availability of large, extensively-phenotyped human brain tissue collections that have been amassed by the Neuro-HIV research community. In addition, sophisticated animal models that have been developed for both conditions provide a means to precisely evaluate specific exposures and stages of disease. We propose that single-cell genomics is a uniquely powerful technology to characterize the effects of SUD and HIV in the brain, integrating data from human cohorts and animal models. We have formed the Single-Cell Opioid Responses in the Context of HIV (SCORCH) consortium to carry out this strategy.