bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental therapeutics for patients with myeloproliferative neoplasias
Authors: Agrawal Meetu , Garg Ravin J. , Cortes Jorge , Kantarjian Hagop , Verstovsek Srdan , Quintas‐Cardama Alfonso 
Published: October 2010

AbstractPhiladelphia chromosome (Ph)‐negative myeloproliferative neoplasms (MPNs) are characterized by stem cell‐derived, unrestrained clonal myeloproliferation. The World Health Organization classification system, proposed in 2008, identifies 7 distinct categories of Ph‐negative MPNs including essential thrombocythemia (ET); polycythemia vera (PV); primary myelofibrosis (PMF); mastocytosis; chronic eosinophilic leukemia; chronic neutrophilic leukemia; and MPN, unclassifiable. For many years, the treatment of ET, PV, and PMF, the most frequently diagnosed Ph‐negative MPNs, has been largely supportive. In recent years, that paradigm has been challenged because of the discovery of a recurrent point mutation in the Janus kinase 2 (JAK2) gene (JAK2V617F). This mutation can be detected in the vast majority of patients with PV and approximately half of patients with ET or PMF and serves as both a diagnostic marker as well as representing a putative molecular target for drug development. Several putative targeted agents with significant in vitro JAK2 inhibitory activity and various degrees of JAK2 specificity are currently undergoing clinical evaluation. Furthermore, other investigational non‐tyrosine kinase inhibitor approaches such as immunomodulatory agents and pegylated interferon‐α have also shown promising results in MPNs. Cancer 2011. © 2010 American Cancer Society.
Increased polyclonal CD5+ B1a lymphocytes in a haploidentical stem cell transplant recipient
Authors: Hillard Robert A. , Lekakis Lazaros J. , Pulliam Joseph F. 
Published: October 2010

AbstractBackground:Atypical lymphocyte populations may be seen in the peritransplant setting. In this case report, we describe an unusually high number of CD5+ B‐cells (B1a cells) following transplant.Methods:B1a cells identified during routine follow‐up by immunophenotypic analysis in a middle‐aged man who had a haploidentical stem cell transplant for acute myeloid leukemia were compared with a reference set of post‐transplant samples.Results:Increased but polyclonal B1a cells were identified with 100% donor chimerism.Conclusions:Our case demonstrates that a high absolute number of B1a cells may be seen post‐transplant and should not be confused with an atypical CD5+ lymphoproliferative disorder. Furthermore, the population of polyclonal CD5+ B lymphocytes from the patient's donor is prominent 7 months post‐transplant. This suggests that the maintenance of CD5+ B1 cells prior to conversion to adult‐type CD5− B2 cells is not hindered by the recipient adult stromal environment. © 2010 International Clinical Cytometry Society
Glandular cells in vaginal cytology Papanicolaou tests in patients with hysterectomy for endometrial adenocarcinoma
Authors: Steele Erica , Umar Saleem A. , Bomeisl Philip , Miedler John , Zanotti Kristine M. , Wasman Jay K. , Hunt Daniel C. , Abdul‐Karim Fadi W. 
Published: October 2010

AbstractThe vaginal apex is the most common site of recurrence in patients with endometrial cancer. Although studies demonstrate that <1% of asymptomatic vaginal recurrences are detected by routine vaginal cytology alone, many practitioners still include it as part of the routine surveillance in these patients after hysterectomy. To further evaluate the effectiveness of vaginal cytology as a surveillance tool, we assessed the subsequent findings in patients reported to have benign and atypical glandular cells on vaginal cytology after hysterectomy performed for endometrial cancer. Diagn. Cytopathol. 2011. © 2010 Wiley Periodicals, Inc.
Pharmaceutical development of IPI‐504, an Hsp90 inhibitor and clinical candidate for the treatment of cancer
Authors: Porter James R. , Adams Julian , Ahn Rebecca , Ammoscato Vince , Arsenault Brendan , Austad Brian C. , Baker Gary , Basuki Johan , Booth Marlene R. , Campbell Matthew J. , Carter Bennett , Curtis Michael , Depew Kris , Douglas Mark A. , Ge Jie , Grenier Louis , Helble Joseph , Henderson John , Goltz Natalie , Ionescu Dumitru , Kott Laila , Kropp Jason T. , Lee John , Li Kaiming , Maurer Bradley , Mayes Denise , Pak Roger H. , Piotrowski Jason , Porter Jennifer R. , Rusch David , Sylvester Geoff E. , Wong Steven , Wright Jim 
Published: October 2010

AbstractIPI‐504 (retaspimycin hydrochloride) is an Hsp90 inhibitor that is the subject of multiple clinical trials for the treatment of cancer. IPI‐504 is an aqueous soluble (>200 mg/ml) hydroquinone hydrochloride salt of 17‐(allylamino)‐17‐demethoxygeldanamycin (17‐AAG), a quinone derivative also undergoing clinical evaluation, albeit with suboptimal formulations that address its inferior aqueous solubility (∼50 µg/ml). IPI‐504 interconverts with 17‐AAG in vivo through oxidation‐reduction reactions that result in a dynamic redox equilibrium. The development challenges associated with redox active molecules are significant due to the pH, oxygen, and temperature sensitivities associated with such chemotypes. The API and sterile drug product manufacturing processes thus warrant the monitoring and control of these key variables. Furthermore, the pharmaceutical development challenges associated with cancer agents that are often fast‐tracked due to unmet medical needs mandate a rapid development cycle with associated regulatory hurdles. Drug Dev Res 71: 429–438, 2010. © 2010 Wiley‐Liss, Inc.
Conflict, migration and land‐cover changes in Indochina: a hydrological assessment
Authors: Lacombe G. , Pierret A. , Hoanh C. T. , Sengtaheuanghoung O. , Noble A. D. 
Published: October 2010

AbstractThe Indochinese section of the Mekong Basin has been subjected to major environmental disturbances over the last half century. The Vietnam War is invoked as a central explanation for the extensive deforestation in specific areas while conflict‐induced exoduses caused the abandonment of cultivated lands, followed by forest regeneration. Although the socio‐economical consequences of these episodes have been analysed, their hydrological impacts remain unknown. This paper investigates hydrological changes in two catchments of the lower Mekong Basin that were either heavily bombed (in southern Laos) or depopulated (in northern Laos). This analysis is based on the widely and independently recognized fact that vegetation, via evapotranspiration, is a central driver of basin water yield. The analysis of the most complete Vietnam War air mission database and of available hydro‐meteorological data over the period 1960–2004 reveals a sharp runoff increase in the southern catchment when bombing climaxed in the early 1970s while no hydrological change is observed in the northern catchment over the same period. From 1995 onwards, the northern and southern catchment's runoff productions are significantly lower and higher than in the pre‐war conditions, respectively. Although causalities could not be ascertained because of data limitations, these short‐ and long‐term hydrological shifts were found to be consistent, in terms of occurrence, spatial distribution and magnitude, with the expected changes in the vegetation cover, either denser in the north (in response to abandonment of cultivated lands) or sparser in the south (as a result of bomb‐induced deforestation and soil degradations). Copyright © 2010 John Wiley & Sons, Ltd.
Additive Differential Pulse Voltammetry for the Study of Slow Charge Transfer Processes at Spherical Electrodes
Authors: Laborda Eduardo , Rogers Emma I. , Martínez‐Ortiz Francisco , Molina Ángela , Compton Richard G. 
Published: October 2010

AbstractThe application of additive differential pulse voltammetry to the study of the kinetics of a charge transfer process is studied. A simple analytical solution is presented, valid for spherical electrodes of any size and for electrode processes of any reversibility. From this solution, valuable diagnostic criteria for the elucidation of the electrochemical reversibility are established based on the variation of the ADPV signal with the duration of the potential pulses, the electrode radius and the pulse height. Working curves for the determination of the kinetic parameters are also given. The value of the ADPV technique is experimentally demonstrated by studying the kinetics of the reduction of 3‐nitrophenolate− and europium3+ at mercury hemispherical microelectrodes.
Forecast accuracy and effort: The case of US inflation rates
Authors: Taylor Nicholas 
Published: October 2010

AbstractThis paper investigates the relationship between forecast accuracy and effort, where effort is defined as the number of times the model used to generate forecasts is recursively estimated over the full sample period. More specifically, within a framework of costly effort, optimal effort strategies are derived under the assumption that the dynamics of the variable of interest follow an autoregressive‐type process. Results indicate that the strategies are fairly robust over a wide range of linear and nonlinear processes (including structural break processes), and deliver forecasts of transitory, core and total inflation that require less effort to generate and are as accurate as (that is, are insignificantly different from) those produced with maximum effort. Copyright © 2010 John Wiley & Sons, Ltd.
Gotthard Base Tunnel – Tunnelling in the influence zone of two concrete arch dams /
Authors: Ehrbar Heinz , Bremen Roger , Otto Bastian 
Published: October 2010

AbstractThe determination of the alignment of the Gotthard Base Tunnel made sure not to tunnel directly under the dams of the Vorderrhein AG power stations. The Gotthard Base Tunnel will, however, have to be driven through the zone, which could affect the three arch dams at Nalps, Santa Maria and Curnera.The Zeuzier dam in Wallis (Valais) suffered severe damage in 1978 as the result of drainage of the rock mass for an investigation tunnel being driven in the vicinity. The cracks in the dam led to years of operational limitations and required extensive repair works.A whole range of measures was undertaken for the Gotthard Base Tunnel in order to avoid a repetition. The construction of the tunnel near the dam was the subject of years of preparatory work. Since the end of 2005, the southward drive from Sedrun has been near the Nalps dam and since the middle of 2009, that from Faido has been within the zone influencing the Santa Maria dam. Long‐term safe operation of both dams has to be ensured despite the near approach of the tunnelling works. Although the task is the same for both dams, completely different solutions were chosen. The following paper explains the reasons for thisBei der Festlegung der Linienführung für den Gotthard Basistunnel wurde darauf geachtet, dass die Stauanlagen der Kraftwerke Vorderrhein AG nicht direkt unterfahren werden. Der Gotthard Basistunnel muss jedoch im Einflussbereich der drei Bogenstaumauern Nalps, Santa Maria und Curnera vorgetrieben werden.Die Staumauer Zeuzier im Wallis erlitt im Jahr 1978 als Folge der Gebirgsentwässerung eines in der Nähe vorgetriebenen Sondierstollens schwere Schäden. Die Risse in der Mauer führten zu jahrelangen Betriebseinschränkungen und lösten umfangreiche Sanierungsmaßnahmen aus.Am Gotthard Basistunnel wurde somit eine ganze Anzahl von Maßnahmen getroffen damit ein solcher Zwischenfall sich nicht wiederholt. In jahrelangen Vorarbeiten wurde der Tunnelbau in der Nähe der Stauanlagen vorbereitet. Seit Ende 2005 befindet sich der von Sedrun ausgeführte Südvortrieb im Bereich der Stauanlage Nalps und seit Mitte 2009 jener von Faido aus im Einflussbereich der Stauhaltung Santa Maria. Bei beiden Mauern muss langfristig ein sicherer Betrieb der Stauanlagen, unter Berücksichtigung des in der Nähe vorgenommenen Tunnelvortriebs, gewährleistet werden. Obwohl die Aufgabenstellung in beiden Fällen identisch war, wurden schließlich für die zwei Mauern zwei komplett unterschiedliche Lösungsansätze gewählt. Der nachfolgende Beitrag zeigt die Gründe dazu auf.
Considerations of the crack water table and its fluctuation in pressure tunnel design and construction /
Authors: Vigl Alois , Gerstner Reinhold 
Published: October 2010

AbstractIn pressure tunnel construction, the crack water table plays a varied role, often important and decisive with regard to technology, safety, cost‐effectiveness and environmental relevance. This paper is concerned with the crack water table and its natural range of fluctuation, with the relaxation of crack water pressure due to tunnelling, the interaction between internal tunnel pressure and crack water as it affects lining and waterproofing and the influence of the crack water by the operation of the tunnel.Im Druckstollenbau spielt der Bergwasserspiegel eine vielfältige und hinsichtlich Technik, Sicherheit, Wirtschaftlichkeit und Umweltrelevanz eine wichtige und oft entscheidende Rolle. Der Beitrag beschäftigt sich mit dem Bergwasserniveau und seiner natürlichen Schwankungsbreite, mit der Bergwasserentspannung durch den Vortrieb, mit dem Zusammenwirken von Stolleninnendruck und Bergwasser im Hinblick auf Auskleidung und Abdichtung sowie mit der Beeinflussung des Bergwassers durch den Betrieb des Druckstollens.
Deep geothermal energy – an interdisciplinary challenge. Shaft with 3D underground collector as heat exchanger /
Authors: Muser Christoph , Hämmerle Hubert , Galler Robert , Schubert Wulf 
Published: October 2010

AbstractThe “Deep geothermal power station” project represents a new process for the exploitation of geothermal energy. District heating and heating for industrial purposes as well as electricity can be produced in a geothermal power station. The heat extraction will be controlled and continuous in a closed circulation system using drillings from a mined system of tunnels at a depth of 6,000 m. In order to overcome the high temperatures and rock pressures to be expected, interdisciplinary collaboration between several professions will be required.Das Projekt “Geothermietiefenkraftwerk” stellt einen neuen Verfahrensansatz in der Nutzung geothermischer Energie dar. Fernund Prozesswärme sowie Elektrizität werden hierbei in einem geothermischen Großkraftwerk erschlossen. Die Wärmegewinnung erfolgt kontrolliert und kontinuierlich in einem geschlossenen Kreislauf mittels Bohrungen von einem bergmännisch aufgefahrenen Stollensystem in einer Teufe von 6.000 m. Zur Beherrschung der hohen Temperaturen und Gebirgsdrücke ist eine interdisziplinäre Zusammenarbeit mehrerer Fachdisziplinen erforderlich.
Tapovan‐Vishnugad hydroelectric power project – experience with TBM excavation under high rock cover /
Authors: Brandl Johann , Gupta V. K. , Millen Bernard 
Published: October 2010

AbstractNTPC Ltd. of India is presently constructing the 520 MW (4 x 30 MW) Tapovan‐Vishnugad hydroelectric power plant in Uttarakhand in the Himalayas. As part of this project, an approximately 12.1 km head race tunnel (HRT) is to be constructed, of which approximately 8.6 km are being excavated by DS‐TBM with an excavation diameter of 6.575 m. Construction of this HRT has been awarded to a Joint Venture (JV) of Larsen, Toubro Ltd., India, and Alpine, Austria. Geoconsult ZT GmbH is acting as a Consultant to NTPC Ltd. for the TBM part of the HRT. The overburden above the tunnel is up to 1, 100 m with the result that knowledge of the geology along the HRT alignment could only be based on projections made from surface exposures available in the area. Basically, the ground consists of jointed quartzite, gneiss and schist. Excavation of the HRT started in October 2008 and excavation rates of over 500 m per month were achieved in November 2009. However, in December 2009 the TBM encountered a fault zone along with high‐pressure water inflow and became trapped. This paper outlines the present status of HRT construction and describes in particular the difficulties encountered during TBM excavation in fault zones with large high‐pressure water inflows and how these problems are being dealt with.Die indische Firma NTPC Ltd. errichtet derzeit das 520 MW (4 x 130 MW) Tapovan‐Vishnugad Wasserkraftwerk in Uttarakhand, Himalaya. Als Teil dieses Projekts wird ein ungefähr 12,1 km langer Triebwasserstollen (TWS) errichtet, wobei rund 8,6 km davon mittels einer DS‐TBM mit einem Ausbruchdurchmesser von 6.575 m aufgefahren werden. Der Bau dieses Triebwasserstollens wurde an die Arbeitsgemeinschaft Larsen, Toubro Ltd., Indien, und Alpine, Österreich vergeben. Geoconsult ZT GmbH fungiert als Berater von NTPC Ltd. für den TBM‐Teil des TWS. Aufgrund der Überlagerung des Tunnels von bis zu 1,100 m konnte die Geologie entlang des Triebwasserstollens nur durch Projektion von vorhandenen Oberflächenaufschlüssen aus der Umgebung bestimmt werden. Das Gebirge besteht hauptsächlich aus geklüftetem Quarzit, Gneis und Schiefer. Der Ausbruch des TWS begann im Oktober 2008. Im November 2009 wurde eine Vortriebsgeschwindigkeit von über 500 m pro Monat erreicht. Im Dezember 2009 jedoch fuhr die TBM eine Störzone mit einem Hochdruckwassereinbruch an, wodurch die TBM stecken blieb. Dieser Artikel skizziert den derzeitigen Stand des TWS und legt besonderes Augenmerk auf die Schwierigkeiten beim Auffahren der Störzone inklusive Hochdruckwassereinbruch mit einer TBM. Darüber hinaus wird gezeigt, wie sich die auftretenden Probleme lösen lassen.
A STEP‐based Generic Product Modeling Architecture for collaborative injection moulding product development
Authors: Ai Qingsong , Zhou Zude , Liu Quan , Xie Shengquan , Yang Weizhou 
Published: October 2010

AbstractA STEP (STandard for Exchange of Product model data)‐based Generic Product Modeling Architecture (GPMA) for efficient information sharing and exchange in support of collaborative injection moulding product development, is proposed in this article. The architecture consists of four functional components: an EXPRESS Data Model (EDM), a STEP‐based modeling environment, a five‐phase modeling method, and three EDM data exchange and sharing methods. The focus of this article is on the modeling methodologies and the definition of schemas for modeling all the important information during the life cycle of injection moulding product development. The information structure is well defined in EXPRESS language, which allows the creation of user‐defined data types and the definition of more complex entities for injection moulding products. Because the proposed GPMA is based on STEP, it can provide standardized mechanisms for representing and exchanging product model data, is extendable, and is adaptable. A prototype system named the World Wide Web–based Product Information Sharing System was developed based on the proposed GPMA. The system is then applied to a Chinese injection moulding enterprise to support the collaborative product development of a new product, and the results validated the feasibility of the proposed GPMA. © 2010 Wiley Periodicals, Inc.
Safety climate and pesticide risk communication disparities in crop production by ethnicity
Authors: Smith‐Jackson Tonya , Wogalter Michael S. , Quintela Yvette 
Published: October 2010

AbstractPesticide safety is a significant global health concern. This study explored factors associated with the risk divide, a term used to describe disparities in injuries and fatalities between majority and minority workers. Forty (40) farm workers from the South‐Atlantic region of the United States were recruited. Results revealed significant differences between ethnic groups on several measured constructs. Latino migrant workers (from the Americas) reported lower perceived control of their work environment and higher risk perception compared to Americans of European descent. Preliminary recommendations relevant to cultural ergonomics, risk communication usability, and safety climate are provided. Implications relevant to farm and manufacturing settings are discussed. © 2010 Wiley Periodicals, Inc.
Virtual Reality and its potential for evaluating warning compliance
Authors: Duarte Emília , Rebelo Francisco , Wogalter Michael S. 
Published: October 2010

AbstractBehavioral compliance is usually considered the best measure of warning effectiveness. Researching behavioral effects is difficult to carry out, however, due to concerns for safety, ethics, and high costs. Researchers cannot expose participants to real hazards while conducting a research. A realistic scenario that appears risky but that actually has no risk is expensive to conduct in terms of money, time, and effort. This article reflects on the potential of Virtual Reality (VR) as a technique to investigate warning effectiveness, particularly behavioral compliance. VR may help to overcome several key constraints that have limited warning compliance research, such as hazards actually being manipulated. This article focuses on two information‐processing stages that will most likely benefit from VR: attention and behavior. Increasingly realistic VR can provide high‐quality Virtual Environments (VEs) for use in warnings research. VEs can provide ecological validity and experimental control while limiting actual physical harm. Advantages and limitations are reviewed. © 2010 Wiley Periodicals, Inc.
Involvement of the p75NTR signaling pathway in persistent synaptic suppression coupled with synapse elimination following repeated long‐term depression induction
Authors: Egashira Yoshihiro , Tanaka Tsunehiro , Soni Priyanka , Sakuragi Shigeo , Tominaga‐Yoshino Keiko , Ogura Akihiko 
Published: October 2010

AbstractSynaptic plasticity, especially structural plasticity, is thought to be a basis for long‐lasting memory. We previously reported that, in rat hippocampus slice cultures, repeated induction of long‐term depression (LTD) by application of a metabotropic glutamate receptor (mGluR) agonist led to slowly developing, long‐lasting synaptic suppression coupled with synapse elimination. We referred to this phenomenon as LOSS (LTD‐repetition‐operated synaptic suppression) to discriminate it from conventional single LTD and proposed it as a model for analyzing structural plasticity. Recently, proneurotrophin‐activated p75NTR signaling has been gaining attention as a possible pathway for the regulation of both neuronal apoptosis and synaptic plasticity. In this study, we examined whether this signaling has a role in the establishment of LOSS. The application of anisomycin indicated that, for LOSS to occur, novel protein synthesis is needed within 6 hr after the induction of mGluR‐dependent LTD, which demonstrates that LOSS is an active process and therefore is not due to withering in response to a shortage of trophic factors. Furthermore, we found that pro‐BDNF (a species of proneurotrophins) is newly synthesized within 6 hr after the induction of LTD. We therefore exogenously applied a cleavage‐resistant form of pro‐BDNF, finding synaptic suppression similar to LOSS. LOSS could be abolished by the application of an antibody that binds to and neutralizes p75NTR following repeated LTD induction. These results suggest involvement of the p75NTR signaling pathway in the long‐lasting decremental form of synaptic plasticity. © 2010 Wiley‐Liss, Inc.