bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scalable Transdiagnostic Early Assessment of Mental Health (STREAM): a study protocol
Authors: Williams Elin H , Thompson Nicholas M , McCray Gareth , Crespo-Llado Maria M , Bhavnani Supriya , Gajria Diksha , Mukherjee Debarati , Del Bianco Teresa , Lockwood-Estrin Georgia , Mason Luke , Ngoma Vukiwe , Namathanga Chisomo , Nkhata Richard , Bennie Allan , Ranjan Alok , Kawelama Ulemu , Midha Naina , Singh Anindita , Mpakiza Innocent , Gautam Akshat , Gulati Sheffali , Johnson Mark H , Lancaster Gillian , Belmonte Matthew K , Jones Emily , Patel Vikram , Chandran Sharat , Mbale Emmie , Divan Gauri , Gladstone Melissa , Chakrabarti Bhismadev 
Published: June 2024

IntroductionEarly childhood development forms the foundations for functioning later in life. Thus, accurate monitoring of developmental trajectories is critical. However, such monitoring often relies on time-intensive assessments which necessitate administration by skilled professionals. This difficulty is exacerbated in low-resource settings where such professionals are predominantly concentrated in urban and often private clinics, making them inaccessible to many. This geographic and economic inaccessibility contributes to a significant ‘detection gap’ where many children who might benefit from support remain undetected. The Scalable Transdiagnostic Early Assessment of Mental Health (STREAM) project aims to bridge this gap by developing an open-source, scalable, tablet-based platform administered by non-specialist workers to assess motor, social and cognitive developmental status. The goal is to deploy STREAM through public health initiatives, maximising opportunities for effective early interventions.Methods and analysisThe STREAM project will enrol and assess 4000 children aged 0–6 years from Malawi (n=2000) and India (n=2000). It integrates three established developmental assessment tools measuring motor, social and cognitive functioning using gamified tasks, observation checklists, parent-report and audio-video recordings. Domain scores for motor, social and cognitive functioning will be developed and assessed for their validity and reliability. These domain scores will then be used to construct age-adjusted developmental reference curves.Ethics and disseminationEthical approval has been obtained from local review boards at each site (India: Sangath Institutional Review Board; All India Institute of Medical Science (AIIMS) Ethics Committee; Indian Council of Medical Research—Health Ministry Screening Committee; Malawi: College of Medicine Research and Ethics Committee; Malawi Ministry of Health—Blantyre District Health Office). The study adheres to Good Clinical Practice standards and the ethical guidelines of the 6th (2008) Declaration of Helsinki. Findings from STREAM will be disseminated to participating families, healthcare professionals, policymakers, educators and researchers, at local, national and international levels through meetings, academic journals and conferences.
Predictive values of indirect ultrasound signs for low risk of acute appendicitis in paediatric patients without visualisation of the appendix on ultrasound
Authors: Pernía Juan , Cancho Teresa , Segovia Inés , de Ponga Pilar , Granda Elena , Velasco Roberto 
Published: June 2024

Background and objectives
The ability to rule appendicitis in or out using ultrasound is limited by studies where the appendix is not visualised. We determined whether the absence of indirect ultrasound signs can rule out appendicitis in children undergoing a radiology-performed ultrasound in which the appendix is not visualised

Methods
This was a single-centre retrospective observational study of patients aged 3–13 with a clinical suspicion of acute appendicitis evaluated in a Paediatric Emergency Department in Spain from 1 January 2013 to 31 December 2019. For those patients who had formal ultrasound, direct and indirect findings of ultrasound were abstracted from the ultrasound report. The surgical pathology report was established as the gold standard in patients who underwent an appendectomy. In those who did not, appendicitis was considered not to be present if there was no evidence in their charts that they had undergone an appendectomy or conservative therapy for appendicitis during the episode. The main outcome variable was the diagnosis of acute appendicitis. For patients undergoing ultrasound, the independent association of each indirect ultrasound sign with the diagnosis of appendicitis in patients without a visualised appendix was analysed using logistic regression.

Results
We included 1756 encounters from 1609 different episodes. Median age at the first visit of each episode was 10.1 years (IQR, 7.7–11.9) and 921 (57.2%) patients were men. There were 730 (41.6%) encounters with an Alvarado score ≤3, 695 (39.6%) with a score 4–6 and 331 (18.9%) with a score ≥7. Appendicitis was diagnosed in 293 (17.8%) episodes. Ultrasonography was performed in 1115 (61.6%) encounters, with a visualised appendix in 592 (53.1%).
The ultrasound findings independently associated with appendicitis in patients without a visualised appendix were the presence of free intra-abdominal fluid in a small quantity (OR:5.0 (95% CI 1.7 to 14.6)) or in an abundant quantity (OR:30.9 (95% CI 3.8 to 252.7)) and inflammation of the peri-appendiceal fat (OR:7.2 (95% CI 1.4 to 38.0)). The absence of free fluid and inflammation of the peri-appendiceal fat ruled out acute appendicitis in patients with an Alvarado score <7 with a sensitivity of 84.6% (95% CI 57.8 to 95.7) and a negative predictive value of 99.4% (95% CI 97.8 to 99.8).

Conclusions
Patients with an Alvarado score <7 and without a visualised appendix on ultrasound but who lack free fluid and inflammation of the peri-appendiceal fat are at very low risk of acute appendicitis.
Medium-term storage of frozen residual antenatal sera in gel separator tube is suitable for subsequent serological investigation of intrauterine infection
Authors: Ng Weiling , Tan Ter Yong , Chow Xin Yu Venessa , Lim Siew Hoon , Wan Wei Yee 
Published: June 2024

AimWe assessed the feasibility of storing sera in primary gel separator tube over medium-term for retrospective serological tests to facilitate investigation of intra-uterine infection.Method120 residual serum samples, consisting of 30 positive samples each for rubella, cytomegalovirus, parvovirus B19 and varicella zoster IgG were aliquoted into secondary propylene tubes and stored together with the original primary tubes at −20°C for 1 year. The serum was subsequently retested to compare results from both storage methods.ResultsHaemolysis was observed in 49.2% of serum stored in the primary tubes. However, there was no difference in both the qualitative and quantitative results after storage of serum samples in either receptacle.ConclusionSera can be stored in primary blood tube for up to 1 year without affecting serological results. For laboratories with adequate freezer space to store samples in primary blood tubes, this would streamline workflow saving manpower and time, avoid mislabelling of aliquots, reduce consumable costs and prevent unnecessary biohazard exposures.
Return to practice for allied health professionals with protected characteristics: a mixed-methods study
Authors: Atwal Anita , Sriram Vimal , Brice Jos 
Published: June 2024

IntroductionReturn to practice is one mechanism for recruiting and retaining allied health professionals (AHPs) within the health and care workforce in England. It is not known how this affects persons with protected characteristics.AimTo understand experiences of AHPs with protected characteristics of returning to the workforce through a return to practice programme.MethodA QUAL (semistructured interviews) + qual (focus group interviews) mixed-methods study. 12 online semistructured interviews with return to practice AHPs, followed by 2 online focus groups.ResultsOur research identifies a new type of returners who have to use the return to practice programme as a vehicle to step into health and social care as they have not been able to find employment. A main driver to return to practice was financial reason.ConclusionTo date there, is little evidence of leaders understanding the complexities of AHPs in a return to practice programme, the considerable contribution they can make to the workplace and the current inequities that exist.
Modeling slough crayfish populations in response to hydrologic variability
Authors: Sinnickson Dylan , Dorn Nathan J. 
Published: June 2024

Understanding and predicting animal population dynamics as a function of hydrologic variation is critical for the management of freshwater ecosystems. Crayfish are important fauna supported by the hydro-dynamic freshwater wetlands of the Everglades. We modeled the complex relationships between slough crayfish ( Procambarus fallax) population densities and hydrologic conditions using a spatially and temporally extensive 21-year dataset. We applied linear mixed–effect models, a classification and regression tree (CART), and random forest (RF) algorithms to develop predictions and eco-hydrologic interpretations. The RF model demonstrated the greatest predictive ability ( R2 = 0.56) followed by linear mixed–effect models ( R2 = 0.45) and the regression tree ( R2 = 0.29). Primary effects of hydrologic terms were similar among models, but the RF model identified important nonlinear and threshold relationships. Lower average depths (appr. 30–60 cm) over the year prior to the sample, in conjunction with relatively long periods of inundation, and more recent depths >30 cm, were associated with greater crayfish densities. The three methods revealed consistent understanding of crayfish eco-hydrologic relations and provide insight for natural resource management.
Enantioanalysis of Leucine and Arginine: A Key Factor in Lung Cancer Metabolomics
Authors: Comnea-Stancu Ionela Raluca , Stefan-van Staden Raluca-Ioana , van Staden Jacobus (Koos) Frederick 
Published: June 2024

Metabolomics has become a key factor for identifying new biomarkers able to be used for early diagnosis of cancer. A zinc oxide-α-cyclodextrin nanocarbon nanocomposite 3D stochastic microsensor (α-CD/ZnO/nanoC) was designed and integrated into an intelligent 3D stochastic enantioselective platform for the enantioanalysis of arginine and leucine in whole blood samples. The α-CD/ZnO/nanoC pastes were morphologicaly characterized by scanning electron microscopy, and electrochemically characterized by cyclic voltammetry and electrochemical impedance spectroscopy. L-Leucine was determined on a working concentration range between 1 × 10−11–1 × 10−8 mol l−1 with a limit of detection of 3 × 10−12 mol l−1; D-leucine was determined on a working concentration range between 1 × 10−16–1 × 10−11 mol l−1 with a limit of detection of 3 × 10−17 mol l−1; L-arginine was determined on a working concentration range between 1 × 10−12–1 × 10−9 mol l−1 with a limit of detection of 3 × 10−13 mol l−1; D-arginine was determined on a working concentration range between 1 × 10−14–1 × 10−11 mol l−1 with a limit of detection of 3 × 10−15 mol l−1. High sensitivities, selectivities, and enantioselectivities were recorded when the platform was used for the enantioanalysis of arginine and leucine. High recoveries were recorded at the enantioanalysis of arginine/leucine, with low relative standard deviations.
Vodcast as ideating medium in STEM lesson plan in teaching heat transfer
Authors: Guden Jester Mark , Alguno Arnold C. , Sayson Noel Lito B. , Magsayo Joy R. , Jr. Sotero O. Malayao 
Published: June 2024

This study attempts to link the clay soil in the locality to the topic of heat transfer as a contextualization point. It attempted to slightly modify the seven-step STEM lesson by having the part of the prototyping be first tried by the teacher, thereby having a change-of-hat to anticipate the ‘what if’ questions of the students. The teacher-researchers experimentation provided critical information to scaffold the students in the prototyping part. The evaluation of experts shows that the modified STEM lesson can be an excellent tool and the vodcast has been found to be a very satisfactory component of the STEM lesson. It is described as a very useful material in teaching heat transfer and related thermodynamics concepts and is highly recommended for use in both distance learning and face-to-face modality. Further, the clay oven exploration has come up with a refined clay oven production process, wherein the clay oven prototype has the capacity for the contextualization of heat transfer. It is recommended that a formal implementation be conducted to refine and standardize the lesson delivery.
Indicadores que interpretam fatores humanos na arquitetura hospitalar
Authors: Mendes Ludmila Cardoso Fagundes , Souza Roberta Vieira Gonçalves de 
Published: June 2024

A Teoria do Design de Suporte (TDS) e o Design Baseado em Evidências (DBE) apresentam componentes para reduzir o estresse e promover o bem-estar em ambientes hospitalares. Esta pesquisa buscou analisar indicadores relativos a fatores humanos em um hospital, através da investigação da TDS e do DBE. A finalidade das edificações hospitalares justifica analisar a abordagem de indicadores de bem-estar nas publicações do Ministério da Saúde e nos sistemas de certificação de edifícios. O método incluiu a identificação e seleção dos indicadores mais relevantes; aplicação destes em um estudo de caso e proposição para preenchimento de lacunas identificadas na avaliação dos indicadores. Foram identificados 22 indicadores de bem-estar. Destes, 5 foram selecionados para análise no centro de terapia intensiva e nas áreas comuns de um hospital: controle individual da iluminação artificial; áreas de estar, descanso e copa para funcionários; áreas ou jardins para convivência; vistas de qualidade e disponibilidade de luz do dia. O estudo de caso atendeu plenamente a 40% (controle individual da iluminação natural e vistas de qualidade), parcialmente a 40% (áreas de estar, descanso e copa para funcionários e áreas ou jardins para convivência), e não atendeu a 20% dos indicadores selecionados (disponibilidade de luz do dia). Acredita-se que as principais barreiras para aplicar os indicadores de bem-estar estejam associadas à concepção arquitetônica e ao local de implantação dos estabelecimentos. A pesquisa mostrou a relevância de programas de necessidades para edificações hospitalares que extrapolem as exigências da RDC50/2002.
Impact of White Matter Hyperintensity Volume on Prognosis After Mechanical Thrombectomy in Ischemic Stroke Patients
Authors: Hancer Théo , Kyheng Maéva , Labreuche Julien , Gauberti Maxime , Touzé Emmanuel , Boulouis Grégoire , Lapergue Bertrand , Boulanger Marion ,   the ETIS Registry Investigators
Published: June 2024

Background
Uncertainties remain about the impact of white matter hyperintensity (WMH) on prognosis after mechanical thrombectomy.

Methods
In this retrospective study from a national prospective registry of patients with ischemic stroke due to large vessel occlusion treated with mechanical thrombectomy, we assessed WMH volume using a quantitative semi‐automatized segmentation on baseline magnetic resonance imaging. We determined the association between WMH volume and the prognosis of patients with ischemic stroke presenting between 2019 and 2022.

Results
Among 902 patients (mean age 70.4 years, 50% women) with a baseline magnetic resonance imaging, the median WMH volume was 2.79 (0.75–9.14) mL. In multivariate analyses, increasing WMH volume was associated with a reduced probability of favorable outcome (modified Rankin Scale score 0–2) (adjusted odds ratio per 1 log+1 increase = 0.66, 95% confidence interval 0.54–0.82) and an increased risk of mortality at 90 days (adjusted odds ratio per 1 log+1 increase = 1.53, 95% confidence interval 1.23–1.90), with the greatest risk in patients with the highest WMH volume (>11 mL) compared to those with the lowest WMH volume (<2 mL) (adjusted odds ratio = 0.38, 95% confidence interval 0.21–0.67 and adjusted odds ratio = 3.04, 95% confidence interval 1.66–5.59, respectively). There was no association between WMH volume and recanalization success and risks of any post treatment intracranial hemorrhage, symptomatic intracranial hemorrhage, and parenchymal hemorrhage.

Conclusion
WMH volume is associated with increased risks of poor functional outcome and death at 90 days post mechanical thrombectomy but not with the probability of recanalization success and posttreatment intracranial hemorrhage. The use of semi‐automatized tool to assess WMH volume may help better identify patients who would benefit the most from mechanical thrombectomy and predict their prognosis.
Applications of interpretable deep learning in neuroimaging: A comprehensive review
Authors: Munroe Lindsay , da Silva Mariana , Heidari Faezeh , Grigorescu Irina , Dahan Simon , Robinson Emma C. , Deprez Maria , So Po-Wah 
Published: June 2024

Abstract
Clinical adoption of deep learning models has been hindered, in part, because the “black-box” nature of neural networks leads to concerns regarding their trustworthiness and reliability. These concerns are particularly relevant in the field of neuroimaging due to the complex brain phenotypes and inter-subject heterogeneity often encountered. The challenge can be addressed by interpretable deep learning (iDL) methods that enable the visualisation and interpretation of the inner workings of deep learning models. This study systematically reviewed the literature on neuroimaging applications of iDL methods and critically analysed how iDL explanation properties were evaluated. Seventy-five studies were included, and ten categories of iDL methods were identified. We also reviewed five properties of iDL explanations that were analysed in the included studies: biological validity, robustness, continuity, selectivity, and downstream task performance. We found that the most popular iDL approaches used in the literature may be sub-optimal for neuroimaging data, and we discussed possible future directions for the field.
“Life in the Divine Image and Likeness”
Authors: Torseth Robb 
Published: June 2024

Abstract
In Michael Allen’s 2017 article, “Toward Theological Anthropology: Tracing the Anthropological Principles of John Webster,” Allen draws attention to the peculiarity of the absence of a formal doctrine of the imago Dei in Webster’s anthropology, noting that 1) the doctrine is exegetically driven and ubiquitous in historical theology, and 2) it would seem to fit well with Webster’s greater theological project. This article will attempt to address both of these points in Webster’s thought, first by considering the question of why the doctrine of the image of God in humanity is largely underdeveloped in Webster’s theology, and second, by considering what Webster has said about the image of God throughout his writings. The article will then analyze Webster’s article “The Dignity of Creatures,” concluding by elaborating on concepts inherent in Webster’s anthropology to approach an answer to the question, “What would a Websterian doctrine of the image of God look like?”
Young and Hungry
Authors: Morris Katie 
Published: June 2024

Abstract
This article evaluates school meal policies in the UK and Ireland as a means to ensure the fulfilment of children’s right to food, as protected under international law. It adopts a comparative approach, assessing the varying strategies adopted across the two jurisdictions and their challenges. Whilst new developments, including the recent expansion of both hot meal provision in Ireland and universal free school meals in Wales and Scotland, are welcomed, the article argues that school meal policies across the UK and Ireland need to be radically rehauled if they are to make any headway in the realisation of children’s right to food.
Faire l’histoire de la mission
Authors: Prudhomme Claude 
Published: June 2024

Résumé
Prenant pour point de départ l’itinéraire qui l’a conduit à choisir l’histoire des missions pour champ de recherche au début des années 1970, l’auteur rappelle que l’étude des missions, longtemps objet périphérique, fortement lié à des objectifs ecclésiastiques, a conquis sa légitimité scientifique. Cette évolution doit beaucoup à l’établissement de liens étroits noués avec l’anthropologie à laquelle les historiens ont souvent emprunté ses démarches (dispositifs d’enquête), ses concepts (syncrétisme), ses modèles d’explication. Cette connivence n’implique pas pour autant de renoncer à la spécificité du récit historique attaché à mettre en évidence l’évolution du fait missionnaire dans la durée et la singularité des cas observés. Mais les chercheurs restent confrontés aux limites de leurs outils théoriques et à la difficulté de construire une histoire qui prend en compte le rapport à la théologie sans y être subordonnée (missiologie). Il s’interroge enfin sur l’usage extensif du terme « mission », dont le sens est aujourd’hui brouillé par sa sécularisation et son application à tout mouvement intellectuel ou religieux à caractère militant.
Shaping “Reach Out, Build Up, Send Back”
Authors: Sim Joshua Dao Wei 
Published: June 2024

Abstract
Why did Asian Christian international students return home with a missionary mindset during the Cold War? This study answers the question by investigating Overseas Christian Fellowship (OCF) Australia and its student returnee mission. I show that OCF’s returnee mission was shaped by Australia’s Cold War foreign policy – the Colombo Plan Scheme. The paper argues that the time-limited conditions imposed by the Scheme established a migratory and educational training pattern which influenced OCF’s mission of evangelising overseas students and training its members to return home as Christian witnesses. In conclusion, I observe a student-led, faith-based Australia-Asia imaginary emerging from OCF’s mission.