bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rational Type of Laparoscopic Hysterectomy and Safety in Anesthetic Profiles*
Authors: Song Joon , Kim Sun Haeng , Cho Sung Jin , Park Chang Seo , Ku Pyong Sahm 
Published: May 2010

AbstractObjective: To evaluate what type of surgery would be more reasonable among 3 types of laparoscopic hysterectomy and to evaluate the safety of cardio‐pulmonary changes on these patients during these operations.Method: A retrospective study was carried out in 215 women who underwent laparoscopic hysterectomy including laparoscopic‐assisted vaginal hysterectomy (LAVH), laparoscopic hysterectomy (LH), total laparoscopic hysterectomy (TLH). Blood gas analysis, end‐tidal CO2 levels and vital signs were checked and compared with control and preceding values.Results: The average duration of operation was 102.5 min, 83.8 min and 118.3 min for LAVH (n = 97), LH (n = 75) and TLH (n = 43), respectively (p < 0.05). The average amount of bleeding was 297.5 ml, 152.3 ml and 149.2 ml for each type of hysterectomy, respectively. Hemoglobin decreased by an average of 1.6 g/100 ml, 0.9 g/100 ml and 0.8 g/100 ml, respectively. There was a lesser amount of bleeding for LH and TLH than for LAVH (p < 0.05). Profiles of blood gas analysis and expiratory CO2 varied significantly according to the operative stages under controlled anesthesia (p < 0.05), but were within the normal range.Conclusion: These results demonstrate that laparoscopic procedures advancing below the uterine vasculature can be considered effective for hysterctomies and that proper anesthesia can safely control the cardio‐pulmonary changes during laparoscopic hysterectomy.
Umbilical Doppler Velocimetry Prediction of Discordant Twins
Authors: Chittacharoen Apichart , Leelapattana Piboon , Phuapradit Winit 
Published: May 2010

AbstractObjective: To evaluate the role of umbilical Doppler velocimetry as a comprehensive test for the prediction of discordant twins.Methods: The sets of twins were studied with duplex Doppler velocimetry for umbilical artery in third trimester. A systolic/diastolic ratio was measured for each twin. The average difference in the ratios between each twin ≥ 0.4 was used to indicate abnormal test. Discordancy was identified when the birth weight difference of > 25%.Results: Among the 52 sets of twin pregnancies studied, 40 sets of twins fulfilled the study criteria. Eight sets of twins were discordant (20%). The mean gestational age at delivery was 37.15 ± 2.24 weeks (range 28 to 41 weeks). The test correctly identified 6 of the 8 growth discordant twins which had a sensitivity of 75%, specificity of 68.75%, and accuracy of 70%.Conclusion: Umbilical Doppler velocimetry is useful in prediction of discordant twins.
Previous Cesarean Section and Abortion as Risk Factors for Developing Placenta Previa
Authors: Hendricks Marianne S. , Chow Y. H. , Bhagavath B. , Singh Kuldip 
Published: May 2010

AbstractObjective: To determine the risk of subsequent occurrence of placenta previa in women with a history of previous cesarean sections and/or spontaneous and induced abortions.Method: A retrospective analysis of all single gestation deliveries at National University Hospital of Singapore from 1993–1997 was done. Women with placenta previa were identified by clinical or ultrasonographic diagnosis.Results: Of the 16,169 singleton deliveries, 164 women (1.0%) had placenta previa. Women with placenta previa had a significantly higher incidence of previous cesarean sections (p < 0.001). Among the 164 women with placenta previa, women with 1, 2, and 3 previous cesarean sections had 2.2 (95% CI 1.4, 3.4), 4.1 (95% CI 1.9, 8.8) and 22.4 (95%, CI 6.4, 78.3) times increased risk of developing placenta previa respectively. Similarly, women with 2 or more previous abortions had a 2.1 (95% CI 1.2,3.5) times increased risk of subsequently developing placenta previa.Conclusion: There is a strong association between previous cesarean section and risk of subsequent development of placenta previa. This risk increased with the number of previous cesarean sections. Increasing frequency of abortions was also found to predispose a woman to placenta previa.
Emergency Peripartum Hysterectomy at the Princess Badeea Teaching Hospital in North Jordan
Authors: Abu‐Heija Adel T. , Jallad Fayez F. 
Published: May 2010

AbstractObjectives: To study the prevalence, indications and outcome of emergency peripartum hysterectomy in women delivered at the Princess Badeea Teaching Hospital in North Jordan.Method: This is a retrospective study of all cases of emergency peripartum hysterectomy performed between 1st of January 1994 and 31 August 1998.Results: During the study period there were a total of 21 emergency peripartum hysterectomy were performed. The overall incidence was 0.5/1,000 deliveries. The mean age of patients was 34.7 ± 3.9 years, the median parity was 6 and the mean gestational age was 36.9 ± 2.01 weeks.There were 19 cases of caesarean hysterectomy. The leading indication for caesarean section was previous caesarean section (89.5%), placenta previa alone (10.5%). It should be noted that 7 cases with previous caesarean section also had placenta previa (41.2%). The main indications for emergency hysterectomy were, abnormally adherent placenta was the leading indication (38.1%), followed by rupture uterus (33.3%), haemorrhage and uterine atony occurred in 14.3% of cases each, maternal complications occurred in 42.9% of cases postoperatively. There were 4 cases of stillbirths and 2 cases of neonatal deaths.Conclusion: Peripartum hysterectomy remains a necessary procedure for life saving during abdominal and vaginal deliveries. The procedure itself is usually associated considerable perioperative morbidity. Obstetricians should identify patients at risk and anticipate the procedure and complications.
Effect of Vaginal Delivery on the Q‐Tc Interval in a Patient with the Long Q‐T (Romano‐Ward) Syndrome
Authors: Minakami Hisanori , Nakayama Toshio , Ohno Takashi , Kuroki Shigehiro , Sato Ikuo 
Published: May 2010

AbstractTwelve ECG leads were monitored continuously during peripartum in a 23‐year‐old Japanese woman diagnosed as having the long Q‐T (Romano‐Ward) syndrome. Corrected Q‐T (Q‐Tc) intervals determined by 2 investigators blinded from the clinical informations disclosed that the Q‐Tc interval increased during labor, suggesting that physical and/or emotional stress during labor might cause prolonged Q‐Tc intervals in women with the long QT syndrome.
High‐Risk Types of Human Papillomavirus Associated with the Progression of Cervical Dysplasia to Carcinoma
Authors: Saito Junko , Fukuda Takehiko , Hoshiai Hiroshi , Noda Kiichiro 
Published: May 2010

AbstractObjectives: In the past several years, much evidence has accumulated that strongly implicates human papillomavirus (HPV) as an etiological agent of cervical cancer. However, the natural history of HPV infection is not yet completely understood, and at present there is no good marker to predict progression to invasive cancer in individual patients with dysplasia.Methods: Tissue specimens from 45 patients with cervical dysplasia were classified as showing progression to carcinoma (progression group; 26 women), spontaneous regression (regression group; 16 women), and persistence (persistence group; 3 women). The presence of HPV 16, 18, 33, and 52 DNA was examined in 90 formalin‐fixed, paraffin‐embedded surgical and biopsy specimens of dysplasia using the PCR method, and the relationship between the presence of HPV and cervical carcinogenesis was analyzed. The mean follow‐up period was 25.8 months in the progressed group and 34.0 months in both the persistent and regressed groups. The mean ages were 46.4 in the progressed group and 46.8 in the persistent and regressed groups.Results: HPV 16, 18, 33, and 52 DNA were detected in 19 of the 26 patients (73.1%) in the progressed group. All patients with HPV 16, 18, or 52 DNA showed progression to carcinoma. The HPV 33 DNA was detected in 5 of the 16 patients (31.3%) in the regressed group and in 2 of the 3 patients (66.7%) in the persistent group, while HPV 16, 18, and 52 DNA were not detected in the 19 patients that comprised the regressed and persistent groups.Conclusion: This retrospective study suggests that cervical dysplasia in patients with high‐risk types of HPV possessed the potential to progress to carcinoma in situ and eventually to invasive carcinoma as well.
Low‐Dose GnRH Agonist Therapy for the Management of Endometriosis
Authors: Uemura Tsuguo , Shirasu Kazuhiro , Katagiri Nobuyuki , Asukai Kunio , Suzuki Takeshi , Suzuki Naoyuki , Osada Hisafumi , Hiroshi Minaguchi 
Published: May 2010

AbstractObjective: In order to examine whether treatment with a GnRH agonist alone can maintain estrogen levels within the “estrogen window” that inhibits endometriosis without influencing bone‐mineral density, we studied the effects of GnRH agonist therapy and changes in bone‐mineral density.Methods: Buserelin acetate nasal spray was administered 3 times a day for 8 weeks (daily dose, 900 μg) to 21 women with endometriosis. The drug was then given twice a day for 16 weeks (daily dose, 600 μg). The total duration of treatment was 24 weeks. The bone‐mineral density of the lumbar vertebrae was measured by dual‐energy X‐ray absorptiometry before treatment (baseline), at the end of treatment, and 24 weeks after the end of treatment.Results: The bone‐mineral density of the lumbar vertebrae at the end of treatment was 2.44% + 0.46% (mean + standard error) lower than the baseline value. The value at 24 weeks after the end of treatment was 1.10% + 0.64% lower than the baseline value. More than 80% of the patients had serum‐estradiol levels of 45 pg/ml or less. During treatment, more than 90% of the patients had serum‐estradiol levels of 60 pg/ml or less. Genital bleeding was inhibited in 90% of the patients. After 8 weeks of treatment, the clinical symptoms improved in 75% of the patients; such improvement persisted for the duration of the treatment.Conclusion: Decreasing the dose of GnRH agonist during treatment can minimize the loss of bone‐mineral density without lessening the beneficial effects on endometriosis. This technique might be useful in the management of endometriosis.
Recent Management of Malignant Ovarian Germ Cell Tumors: A Study of 34 Cases
Authors: Linasmita Vasant , Srisupundit Somkeart , Wilailak Sarikapan , Tangtrakul Somsak , Israngura Nathapong , Bullangpoti Sunchai 
Published: May 2010

AbstractObjective: To review the outcome of the treatment in patients with malignant ovarian Germ cell tumors with respect to survival and surgical management at a single institution during 1990–1996.Methods: Thirty‐four patients with malignant ovarian Germ cell tumors were studied retrospectively for their surgical management. Fourteen patients had pure dysgerminoma, 11 endodermal sinus tumor, 6 immature teratoma, and 3 mixed Germ cell tumors. Nine patients had stage IA, 8 stage IC, 2 stage IIC, 8 stage III, 3 stage IV, and 4 referred patients with recurrent diseases.Results: Nineteen patients underwent primary conservative surgery, 11 had primary nonconservative surgery. Twenty‐two patients were treated with chemotherapy (BEP or EP or PVB regimen). Five patients with pure dysgerminoma received adjuvant radiotherapy. Persistent remission was achieved in 26 patients. Two patients (7.4%) had recurrence after remission. Seven patients had died of the diseases. Patients with complete clinical remission did not undergo second‐look surgery. The overall survival was 78.8%, 100% for immature teratoma, 84.6% for pure dysgerminoma, 72.8% for endodermal sinus tumor, and 33.3% for mixed Germ cell tumors, with median follow‐up time 31 (3–93) months.Conclusion: Patients with limited diseases regardless of histologic types can be safely managed by unilateral salpingo‐oophorectomy followed by, if indicated, 3–4 courses of cisplatin‐based chemotherapy. For advanced diseases, conservative surgery is advisable in patients with endodermal sinus tumor.
Hyperbaric Oxygenation for Rectovaginal Fistula: A Report of Two Cases
Authors: Dohgomori Hiroshi , Arikawa Kazuhiro , Nobori Masuo , Tonari Masaharu 
Published: May 2010

AbstractA rectovaginal fistula after delivery is a rare complication, and its management can become difficult if infection occurs. In two such cases, we administered hyperbaric oxygenation (HBO) treatment against complicated infections, and we obtained a good outcome in each case.
The Contribution of Menopause to Changes in Body‐Fat Distribution
Authors: Ijuin Hirofumi , Douchi Tsutomu , Oki Toshimichi , Maruta Kuninori , Nagata Yukihiro 
Published: May 2010

AbstractObjective: To investigate whether menopause contributes to changes in body‐fat distribution, irrespective of aging or obesity.Methods: The subjects were 545 premenopausal (aged 16–55 years; mean + standard deviation, 37.7 + 9.1 years) and 219 postmenopausal (aged 45–65 years, 58.0 + 5.0 years) women. Baseline characteristics included age, body mass index (BMI), and menopausal status (premenopause or postmenopause). The ratio of trunk fat to leg fat (trunk‐leg ratio) was estimated by dual‐energy X‐ray absorptiometry. The trunk‐leg ratio and baseline characteristics were compared between the 2 groups. In all subjects (n = 764), possible correlations between the trunk‐leg ratio and the baseline characteristics were determined using univariate and multivariate analysis. In postmenopausal women, the relationsip of the trunk‐leg ratio to YSM or age after adjusting for BMI was investigated.Results: The trunk‐leg ratio and BMI were significantly higher in postmenopausal women than in premenopausal women. In all subjects, age and BMI were positively correlated with the trunk‐leg ratio (r = 0.445 and 0.587, respectively, p < 0.0001). Menopause was also positively correlated with the trunk‐leg ratio on univariate regression analysis (standardized regression coefficient = 0.369, p < 0.0001). On multiple regression analysis, age, BMI, and menopause were independently correlated with the trunk‐leg ratio (p < 0.05). In postmenopausal women, age and YSM were positively correlated with the trunk‐leg ratio, independent of the BMI (p < 0.01).Conclusions: Menopause contributes to a change in body‐fat distribution, irrespective of aging or obesity.
Risk of Recurrence of Fetal Chromosomal Aberrations: Analysis of Trisomy 21, Trisomy 18, Trisomy 13, and 45,X in 1,076 Japanese Mothers
Authors: Uehara Shigeki , Yaegashi Nobuo , Maeda Tohru , Hoshi Nobuhiko , Fujimoto Seiichiro , Fujimori Keiya , Yanagida Kaoru , Yamanaka Michiko , Hirahara Fumiki , Yajima Akira 
Published: May 2010

AbstractObjective: To evaluate the risk of recurrence of fetal chromosomal aberrations in women who had offspring with numeric chromosomal abnormalities.Subjects and Methods: This collaborative study consisted of 1,076 Japanese women with a history of offspring with trisomy‐21, ‐18, ‐13, or 45,X. Second‐trimester amniocenteses were performed, resulting in 1,248 fetal karyotypes that were analyzed with reference to prior offspring karyotypes and maternal age.Results: Of the 842 women with trisomy‐21 offspring, 10 conceived another such fetus. In 2 women with 3 or more such offspring, parental mosaicism of trisomy‐21 was suspected. The incidence of recurrence of trisomy‐21 increased with age, and significantly exceeded the incidence of trisomy‐21 fetuses in the general population. None of the 170 women with trisomy‐18 offspring, and none of the 46 women with trisomy‐13 offspring, had another such fetus. Of the 18 women with 45, X offspring, 1 with mos 45, X/46, XX had another such fetus.Conclusions: The risk of recurrence of trisomy‐21 is affected by maternal age and parental germline mosaicism. The risk of recurrence of trisomy‐18 or ‐13 appears to be much lower than that of trisomy‐21. Women who give birth to more than 1 offspring with 45, X should be examined for mos 45, X/46, XX.
Androgen‐Producing Ovarian Tumors: A Clinicopathological Study of 3 Cases
Authors: Arai Masahide , Jobo Toshiko , Iwaya Hiroaki , Sato Rinya , Watanabe Jun , Ohno Eiji , Kuramoto Hiroyuki 
Published: May 2010

AbstractThe clinical course and pathological findings of 3 rare cases of androgen‐producing ovarian tumors are presented. The ages of the 3 patients (Cases 1, 2, and 3, respectively) were 43, 34, and 57 years, respectively. Their preoperative serum testosterone levels were 506, 491, and 231 ng/dl, respectively. The pathological diagnoses of Cases 1, 2, and 3 were a Sertoli‐stromal cell tumor of intermediate differentiation, a stromal tumor containing Leydig cells, and a stromal tumor with minor sex cord elements, respectively. Patient 1 experienced a recurrence, of a lesion at the vaginal stump 1 year and 2 months after the initial surgery. The clinical courses of Cases 2 and 3 have been non‐contributory.
Emergency Obstetric Hysterectomies for Postpartum Haemorrhage
Authors: Wong Wai‐Chung , Kun Ka‐Yan , Tai Chark‐Man 
Published: May 2010

AbstractObjective: To review emergency obstetric hysterectomy in our unit, including the indications for and morbidity associated with the procedureDesign: A retrospective cases analysis.Subjects and methods: Records of obstetric patients who had undergone emergency hysterectomies in between 15 October 1993 and 31 December 1997 were reviewed retrospectively.Results: There were 15,474 deliveries and 7 emergency obstetric hysterectomies. All cases had total abdominal hysterectomy. The indications for hysterectomy were uterine atony and placental disorders. There were one case of urinary bladder injury and 2 cases of disseminated intravascular coagulopathy. There was no maternal mortality.Conclusion: Emergency obstetric hysterectomy remains a potentially life‐saving procedure in unavoidable catastrophe. The 7 patients with life threatening postpartum haemorrhage underwent hysterectomy after failure of conservative measures. The morbidity is low and there was no mortality in this series.
New Method to Prevent Bladder Dysfunction after Radical Hysterectomy for Uterine Cervical Cancer
Authors: Kuwabara Yoshinori , Suzuki Masaaki , Hashimoto Masanori , Furugen Yoshiaki , Yoshida Koyo , Mitsuhashi Naoki 
Published: May 2010

AbstractObjective: The purpose was to improve the surgical procedures to prevent bladder dysfunction after radical hysterectomy.Methods: Twelve patients with stage Ib cervical cancer underwent intraoperative electrical stimulation to identify the vesical branches of the pelvic nerves. Autonomic nerve localization in the vesicouterine ligament was examined in 10 patients immunohistochemically. According to the results of the above studies a new method to preserve the vesical branches was developed. Grades of postoperative bladder dysfunction were compared between new (n = 19) and conventional methods (n = 18).Results: Electrical stimulation on the outer surface of the posterior sheath of the vesicouterine ligament caused the increase of intravesical pressure. S‐100 protein localized also on this area. Postoperative compliance of the detrusor in cases with the new method demonstrated less decrement from preoperative values than in cases with the conventional method. The new method required significantly fewer days to achieve residual urine volumes less than 50 ml after surgery.Conclusions: The new method significantly reduces bladder dysfunction after radical hysterectomy.
Contraception in Diabetic Women: Comparative Metabolic Study of Norplant, Depot Medroxyprogesterone Acetate, Low Dose Oral Contraceptive Pill and CuT380A
Authors: Diab Khaled M. , Zaki Mona M. 
Published: May 2010

AbstractObjective: To evaluate the long‐term intake of Norplant, depot medroxyprogesterone acetate (DMPA) and low dose oral contraceptive pill (OCs) on glycemic control, lipoprotein metabolism and coagulation profile in diabetic women.Methods: Prospective comparative study including 80 uncomplicated controlled diabetic women. Twenty women allocated to each group. Clinical, metabolic and coagulation status were followed up at 3, 6 and 9 months' visits.Results: Fasting blood sugar increased in OCs and DMPA users. Total cholesterol (TC) and LDL‐cholesterol (LDL‐C) decreased in all groups except DMPA where it increased. Triglyceride (TG) only increased in OCs group. HDL‐cholesterol (HDL‐C) increased with OCs and decreased with Norplant and DMPA. Compared to IUD users, significantly higher percentage TG and HDL‐C and lower LDL‐C were observed in OCs users, while DMPA users had significantly higher TC and LDL‐C and lower HDL‐C. Partial thromboplastin time was prolonged in Norplant users.Conclusion: In diabetics, Norplant results in minimal metabolic alterations followed by OCs while DMPA has unfavorable outcome.
Maternal and Perinatal Outcome of Pregnancies after the Age of 45
Authors: Abu‐Heija Adel T. , Jallad Mohammad F. , Abukteish Faisal 
Published: May 2010

AbstractObjective: To describe the maternal and perinatal outcome of pregnancies in women aged 45 years or more at the time of delivery and to compare them with pregnancies in women aged between 20 and 29 years.Methods: A retrospective review of hospital deliveries after 28 weeks gestation was performed at the Princess Badeea Teaching Hospital in North Jordan for patients delivered between 1st April 1994 and 31st December 1997. We compared the maternal and perinatal outcome of pregnancies in women aged of 45 years or more (study group, n = 114) with women aged between 20–29 years (control group, n = 121) delivered at the same hospital during the same period.Results: The incidence of pregnant women aged 45 years or more was 3.3 per 1,000 births. The median maternal age was 45 years. The majority of women (81.6%) were 45 to 46 years old. Gravidity and parity was significantly higher in the study group (p < 0.0001), also antenatal and medical complications as pre‐eclampsia and diabetes mellitus were higher in the study group. Caesarean section rate, incidences of placental abruption and placenta previa were more common in older patients compared with young patients (32.4 vs 10.7%, 6.1 vs 0.8% and 4.4 vs 1.6%, respectively). There were no differences in the incidences of neonatal deaths, lethal malformations and fetal weight between the 2 groups.Conclusion: Women aged 45 years or more at delivery may expect a good pregnancy outcome but should expect a higher incidences of placental abruption, placenta previa, preeclampsia and caesarean delivery.
A Case of a Screlosing Stromal Ovarian Tumor That Expresses VEGF
Authors: Ishioka Shin‐ichi , Sagae Satoru , Saito Tsuyoshi , Kiya Tamotsu , Akutagawa Noriyuki , Sugimura Masaki , Kudo Ryuichi 
Published: May 2010

AbstractA case of a sclerosing stromal tumor (SST) of the ovary is presented. One of the tumor's characteristics was its high vascularity. On immunohistochemical staining, the vascular endothelial growth factor (VEGF) was positive for both cellular and edematous areas in the tumor. VEGF was thought to be a factor that affected the clinicopathological features of this tumor.
Influence of Female Age on Pregnancy Outcome in in vitro Fertilization and Embryo Transfer Patients Undergoing Intracytoplasmic Sperm Injection***
Authors: Moon Shin Yong , Kim Seok Hyun , Jung Byeong Jun , Jee Byung Chul , Suh Chang Suk , Lee Jin Yong 
Published: May 2010

AbstractPurpose: To determine the influence of female age on the outcomes of ICSI in IVF‐ET patients.Methods: One hundred and seventy‐five couples underwent 352 cycles of ICSI. The quality of oocytes and embryos, fertilization rate, and pregnancy outcomes were retrospectively evaluated according to female age; < 30 years in Group A (49 cycles), 30–34 in Group B (177 cycles), 35–39 in Group C (97 cycles), and ≥ 40 in Group D (29 cycles).Results: The fertilization rates were not significantly different among the age groups. Significant negative linear correlations were observed between female age and the numbers of oocytes retrieved and embryos transferred, and cumulative embryo score. Clinical pregnancy rates were significantly decreased and spontaneous abortion rate increased with advancing age.Conclusions: Female age may be a prognostic indicator in ICSI program.