bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two cases of intracranial germinoma showing a cell arrangement mimicking carcinoma
Authors: Ohta Yoshiki , Suzuki Takao , Tonoike Takahiko , Hamatani Shigeharu , Ohike Nobuyuki , Shiokawa Akira , Kushima Miki , Ota Hidekazu 
Published: October 2009

AbstractTumors of germ cell origin uncommonly arise in extragonadal sites. We report two cases of intracranial germinoma, in which it was necessary to distinguish between intracranial germinoma and metastatic carcinoma in cytological specimens. Cytologically, not only single tumor cells or loosely connective tumor cells but also closely packed clusters of cells and pair cells were recognized. Immunocytochemically, almost all tumor cells were immunoreactive for M2A, placental alkaline phosphatase, and c‐kit. Closely packed clusters were also immunoreactive for pan‐cytokeratin. Therefore, Cytopathologists should be aware that tumor cell clusters, mimicking carcinoma might appear in cytological specimens of intracranial germinomas. Although immunocytochemical analysis assists in correct diagnosis, some cell clusters showing cytokeratin immunoreactivity does not become the basis for the diagnosis of metastaticcarcinoma. A panel of antibodies including D2‐40, PLAP, and c‐kit should be used. Diagn. Cytopathol. 2010. © 2009 Wiley‐Liss, Inc.
Pulmonary crystal‐storing histiocytosis diagnosed by computed tomography‐guided fine‐needle aspiration
Authors: Todd William U. , Drabick Joseph J. , Benninghoff Michael G. , Frauenhoffer Elizabeth E. , Zander Dani S. 
Published: October 2009

AbstractCrystal‐storing histiocytosis (CSH) is a rare process most often occurring in conjunction with an underlying hematopoietic neoplasm, usually multiple myeloma or low‐grade B‐cell lymphoma. We report the first case of pulmonary CSH diagnosed by fine‐needle aspiration biopsy. A patient with a history of urothelial carcinoma developed a lung nodule, which was evaluated by fine‐needle aspiration biopsy. Cytologic examination revealed macrophages with abundant cytoplasmic crystals diagnostic of CSH. Based on this cytologic interpretation, additional clinical laboratory evaluation was pursued and revealed a previously unknown monoclonal serum protein. CSH must be differentiated from other non‐neoplastic and neoplastic lesions and when diagnosed, should trigger a search for an underlying lymphoproliferative disorder. Diagn. Cytopathol. 2010. © 2009 Wiley‐Liss, Inc.
Cytopathologist‐performed ultrasound‐guided fine‐needle aspiration of parathyroid lesions
Authors: Lieu David 
Published: October 2009

AbstractThe gold standard to determine the cause of primary hyperparathyroidism (PHPT) is bilateral neck exploration. As most cases are caused by parathyroid adenoma, there is a movement toward preoperative localization of the abnormal gland by ultrasound and/or Tc99‐sestamibi scan and minimally invasive parathyroidectomy. Nonpalpable thyroid nodules are common and cannot be differentiated from parathyroid lesions by imaging alone. This study examines cytopathologist‐performed ultrasound‐guided fine‐needle aspiration (UG‐FNA) in diagnosis of parathyroid lesions. Between January 1, 2007 and December 31, 2008, seven patients with PHPT or other parathyroid lesions with one or more sonographically‐visible thyroid masses underwent cytopathologist‐performed UG‐FNA with immediate cytological evaluation (ICE). One mass was palpable and nine were nonpalpable. Three parathyroid adenomas, two benign colloid nodules, one papillary carcinoma, three parathyroid cysts, and one thyroid cyst were diagnosed. The nodules in three patients with parathyroid adenomas were identified as follicular lesion/neoplasm on ICE. Additional UG‐FNA passes were made to obtain tissue for immunohistochemistry stains, which confirmed parathyroid origin. Two of these patients had a separate benign colloid nodule and one had a thyroid cyst diagnosed by UG‐FNA. The PHPT patient with papillary carcinoma on UG‐FNA had the malignancy confirmed at surgery and a sonographically occult parathyroid adenoma. The three patients with thyroid cysts identified by radiology were suspected of being parathyroid cysts on the basis of real‐time sonographic features at the biopsy table. The clear cyst fluid obtained by UG‐FNA had markedly elevated PTH. Cytopathologist‐performed UG‐FNA can distinguish between parathyroid and thyroid nodules in patients with suspected parathyroid lesions. Diagn. Cytopathol. 2010. © 2009 Wiley‐Liss, Inc.
Nephroblastoma is a success of paediatric oncologic therapy. How further can we go?: Results of a cyto‐histologic correlation study
Authors: Barroca Helena 
Published: October 2009

AbstractNephroblastoma is a success of paediatric oncologic therapy, yet, there are still some cases where favourable response to preoperative chemotherapy is not achieved. Fine needle biopsy has the role of diagnostic confirmation and, idyllically of predicting a response to preoperative chemotherapy.To advance in this aim, we retrieved a total of 14 nephroblastomas, (seven male patients and seven female with a mean age of 44.4 months), diagnosed in our department by fine needle biopsy and submitted afterward to chemotherapy and nephrectomy, in the last 10 years.Correlation between cytologic features, (morphology, cell death, and proliferation (Ki‐67 labelling index), and post chemotherapy tumour evaluation was done. Cytologic pattern per se was not predictive of histologic tumour classification (P = 0.6061). We did not find any correlation between the percentage of necrosis and apoptosis (P = 0.682) in cytologic smears and histologic regressive changes but when both these two criteria coexisted in cytologic blastemal component of nephroblastomas, this fact seemed to lead to a favourable response of the tumour to chemotherapy. When evaluation of Ki‐67 labelling index was done in the blastematous component present in the smears, divergent results were obtained. The small number of cases prevented any firm conclusions.By summing up, our results support the idea that there are probably two types of blastema in nephroblastoma with different “suicide” potential and chemotherapeutic response. Further studies should be performed to stratify the influence of necrosis, apoptosis, and proliferation in chemosensivity of nephroblastomas. Diagn. Cytopathol. 2010. © 2009 Wiley‐Liss, Inc.
DNA damage and oxidative stress in human liver cell L‐02 caused by surface water extracts during drinking water treatment in a waterworks in China
Authors: Xie Shao‐Hua , Liu Ai‐Lin , Chen Yan‐Yan , Zhang Li , Zhang Hui‐Juan , Jin Bang‐Xiong , Lu Wen‐Hong , Li Xiao‐Yan , Lu Wen‐Qing 
Published: October 2009

AbstractBecause of the daily and life‐long exposure to disinfection by‐products formed during drinking water treatment, potential adverse human health risk of drinking water disinfection is of great concern. Toxicological studies have shown that drinking water treatment increases the genotoxicity of surface water. Drinking water treatment is comprised of different potabilization steps, which greatly influence the levels of genotoxic products in the surface water and thus may alter the toxicity and genotoxicity of surface water. The aim of the present study was to understand the influence of specific steps on toxicity and genotoxicity during the treatment of surface water in a water treatment plant using liquid chlorine as the disinfectant in China. An integrated approach of the comet and oxidative stress assays was used in the study, and the results showed that both the prechlorination and postchlorination steps increased DNA damage and oxidative stress caused by water extracts in human derived L‐02 cells while the tube settling and filtration steps had the opposite effect. This research also highlighted the usefulness of an integrated approach of the comet and oxidative stress assays in evaluating the genotoxicity of surface water during drinking water treatment. Environ. Mol. Mutagen. 2010. © 2009 Wiley‐Liss, Inc.
Broadening the mission of an RNA enzyme
Authors: Marvin Michael C. , Engelke David R. 
Published: October 2009

AbstractThe “RNA World” hypothesis suggests that life developed from RNA enzymes termed ribozymes, which carry out reactions without assistance from proteins. Ribonuclease (RNase) P is one ribozyme that appears to have adapted these origins to modern cellular life by adding protein to the RNA core in order to broaden the potential functions. This RNA‐protein complex plays diverse roles in processing RNA, but its best‐understood reaction is pre‐tRNA maturation, resulting in mature 5' ends of tRNAs. The core catalytic activity resides in the RNA subunit of almost all RNase P enzymes but broader substrate tolerance is required for recognizing not only the diverse sequences of tRNAs, but also additional cellular RNA substrates. This broader substrate tolerance is provided by the addition of protein to the RNA core and allows RNase P to selectively recognize different RNAs, and possibly ribonucleoprotein (RNP) substrates. Thus, increased protein content correlated with evolution from bacteria to eukaryotes has further enhanced substrate potential enabling the enzyme to function in a complex cellular environment. J. Cell. Biochem. 108: 1244–1251, 2009. © 2009 Wiley‐Liss, Inc.
Counseling children at a helpline: chatting or calling?
Authors: Fukkink Ruben , Hermanns Jo 
Published: October 2009

AbstractIn a quantitative content analysis, the telephone‐based and Web‐based support of the Dutch child helpline were studied. Both adult judges and the children themselves indicated that the quality of chat conversations was better than that of telephone conversations. Both the chat and telephone service succeeded in improving children's well‐being and decreasing the perceived burden of their problems. The findings lend support to offer a combined telephone‐based and Web‐based support for child helplines. © 2009 Wiley Periodicals, Inc.
Community attitudes towards culture‐influenced mental illness: scrupulosity vs. nonreligious OCD among orthodox jews
Authors: Pirutinsky Steven , Rosmarin David H. , Pargament Kenneth I. 
Published: October 2009

AbstractCulture may particularly influence community attitudes towards mental illness, when the illness itself is shaped by a cultural context. To explore the influence of culture‐specific, religious symptoms on Orthodox Jewish community attitudes, the authors compared the attitudes of 169 Orthodox Jews, who randomly viewed one of two vignettes describing either religious or nonreligious obsessive–compulsive disorder (OCD). Results indicate that though participants were equally likely to perceive both vignettes as mental illness, they were less likely to endorse psychological/medical explanatory models and help‐seeking, and conversely more likely to endorse social–religious explanations, religious help‐seeking, and stigma in relation to religious OCD. Nevertheless, psychological/medical models and help‐seeking were more strongly endorsed for both religious and nonreligious OCD. Beyond implications for Orthodox Jewish community actions, these findings suggest that attitudes towards mental illness may depend on how symptoms relate to community culture. © 2009 Wiley Periodicals, Inc.
Interpersonal mediators linking acculturation stressors to subsequent internalizing symptoms and self‐esteem in latino adolescents
Authors: Smokowski Paul Richard , Bacallao Martica , Buchanan Rachel Lee 
Published: October 2009

AbstractThe specific aim of this study was to examine pathways leading to internalizing symptoms and self‐esteem in Latino adolescents. Adolescent feelings of interpersonal humiliation, family conflict and commitment, and friendships with peers were investigated as potential mediators linking acculturation stress to subsequent adolescent self‐esteem and internalizing symptoms. Path analyses on data from a sample of 288 Latino adolescents (average age 15 years; 66% foreign‐born) showed that acculturation conflicts and perceived discrimination were risk factors for both internalizing problems at baseline and parent–adolescent conflict 6 months later. Baseline internalizing problems, and Time 2 variables (humiliation, parent–adolescent conflict, negative peer relationships, and changes in familism) mediated the effects of acculturation stress on Time 3 (T3) internalizing symptoms and self‐esteem. Latino cultural involvement was a key cultural asset, impacting T3 internalizing symptoms and self‐esteem by decreasing feelings of humiliation and by promoting familism. Familism was also a critical cultural asset associated with lower parent–adolescent conflict and higher self‐esteem. Study limitations and implications for practice with Latino families were discussed. © 2009 Wiley Periodicals, Inc.
C‐perfect hypergraphs
Authors: Bujtás Csilla , Tuza Zsolt 
Published: October 2009

AbstractLet \documentclass{article}\footskip=0pc\pagestyle{empty}\begin{document}${\mathcal{H}}=({{X}},{\mathcal{E}})$\end{document} be a hypergraph with vertex set X and edge set
\documentclass{article}\footskip=0pc\pagestyle{empty}\begin{document}${\mathcal{E}}$\end{document}. A C‐coloring of \documentclass{article}\footskip=0pc\pagestyle{empty}\begin{document}${\mathcal{H}}$\end{document} is a mapping ϕ:X→ℕ such that |ϕ(E)|<|E| holds for all edges \documentclass{article}\footskip=0pc\pagestyle{empty}\begin{document}${{E}}\in{\mathcal{E}}$\end{document} (i.e. no edge is multicolored). We denote by \documentclass{article}\footskip=0pc\pagestyle{empty}\begin{document}$\bar{\chi}({\mathcal{H}})$\end{document} the maximum number |ϕ(X)| of colors in a C‐coloring. Let further \documentclass{article}\footskip=0pc\pagestyle{empty}\begin{document}$\alpha({\mathcal{H}})$\end{document} denote the largest cardinality of a vertex set S⊆X that contains no \documentclass{article}\footskip=0pc\pagestyle{empty}\begin{document}${{E}}\in{\mathcal{E}}$\end{document}, and \documentclass{article}\footskip=0pc\pagestyle{empty}\begin{document}$\tau({\mathcal{H}})=|{{X}}|-\alpha({\mathcal{H}})$\end{document} the minimum cardinality of a vertex set meeting all \documentclass{article}\footskip=0pc\pagestyle{empty}\begin{document} $E \in {\mathcal{E}}$\end{document}. The hypergraph \documentclass{article}\footskip=0pc\pagestyle{empty}\begin{document} ${\mathcal{H}}$\end{document} is called C‐perfect if \documentclass{article}\footskip=0pc\pagestyle{empty}\begin{document} $\bar{\chi}({\mathcal{H}}\prime)=\alpha({\mathcal{H}}\prime)$\end{document} holds for every induced subhypergraph
\documentclass{article}\footskip=0pc\pagestyle{empty}\begin{document}${\mathcal{H}}\prime\subseteq{\mathcal{H}}$\end{document}. If \documentclass{article}\footskip=0pc\pagestyle{empty}\begin{document}${\mathcal{H}}$\end{document} is not C‐perfect but all of its proper induced subhypergraphs are, then we say that it is minimally C‐imperfect. We prove that for all r, k∈ℕ there exists a finite upper bound h(r, k) on the number of minimally C‐imperfect hypergraphs \documentclass{article}\footskip=0pc\pagestyle{empty}\begin{document}${\mathcal{H}}$\end{document} with \documentclass{article}\footskip=0pc\pagestyle{empty}\begin{document}$\tau({\mathcal{H}})\le {{k}}$\end{document} and without edges of more than r vertices. We give a characterization of minimally C‐imperfect hypergraphs that have τ=2, which also characterizes implicitly the C‐perfect ones with τ=2. From this result we derive an infinite family of new constructions that are minimally C‐imperfect. A characterization of minimally C‐imperfect circular hypergraphs is presented, too. © 2009 Wiley Periodicals, Inc. J Graph Theory 64: 132–149, 2010
Cycle length parities and the chromatic number
Authors: Löwenstein Christian , Rautenbach Dieter , Schiermeyer Ingo 
Published: October 2009

AbstractIn 1966 Erdös and Hajnal proved that the chromatic number of graphs whose odd cycles have lengths at most l is at most l+1. Similarly, in 1992 Gyárfás proved that the chromatic number of graphs which have at most k odd cycle lengths is at most 2k+2 which was originally conjectured by Bollobás and Erdös. Here we consider the influence of the parities of the cycle lengths modulo some odd prime on the chromatic number of graphs. As our main result we prove the following: Let p be an odd prime, k∈ℕ and I⊆{0, 1, …, p−1} with |I|≤p−1. If G is a graph such that the set of cycle lengths of G contains at most k elements which are not in I modulo p, then χ(G)≤(1+|I|/(p−|I|))k+p(p−1)(r(2p, 2p)+1)+1 where r(p, q) denotes the ordinary Ramsey number. © 2009 Wiley Periodicals, Inc. J Graph Theory 64: 210–218, 2010
Vincent's infection of the mouth, throat and larynx. Report of a case
Authors: Wagers A. J. 
Published: October 2009

AbstractVincent's angina as commonly seen is neither of very frequent occurrence nor very serious, is easily diagnosed and in the average case responds readily to treatment; but when we see a case in which the local lesions are extensive and at first not only resist all treatment, but tend to spread and to so undermine the patient's vitality that life hangs by a thread, we believe such a case is worthy of bringing to your attention, particularly since the patient did recover.
CO2 Laser as a clinical tool in otolaryngology
Authors: Lyons George D. , Lousteau Ray J. , Mouney Daniel F. 
Published: October 2009

AbstractThe CO2 laser has been used in a variety of lesions for two and one half years in areas other than the larynx. These lesions include viral papillomas, leukoplakias and erosive lichen planus in various otolaryngological sites. Laser therapy is compared with other modalities of treatment for similar lesions and the advantages and disadvantages of this type treatment is evaluated.
Microsurgical techniques in free flap reconstruction
Authors: Panje W. R. , Krause C. J. , Bardach J. 
Published: October 2009

AbstractFree flap reconstruction is discussed with emphasis on microsurgical technique utilized in union of blood vessels 1 mm in external diameter. Proper microsurgical instrumentation, magnification and small vessel suture technique are all of importance in achieving a successful microvascu‐lar anastomosis. Technical maneuvers employed in identifying and avoiding small vessel thrombosis are presented. Surgical techniques, as presented here, have allowed us to successfully use free flaps to reconstruct large oral cavity defects following ablative cancer operations.
Mediastinal dissection — 1976: Indications and newer techniques
Authors: Sisson George A. , Bytell David E. , Becker Stephen P. 
Published: October 2009

AbstractHead and neck neoplasms may invade the mediastinum by direct extension or metastases to the tracheoesophageal or jugulo‐subclavian lymph nodes. The clavicles and manubrium are a barrier to adequate resection in this type of disease. In 1962, the senior author reported six mediastinal dissections for stomal recurrences after laryngectomy.Later techniques for staging the removal of manubrium and clavicles and preparing the regional flaps were devised to avoid major complications arising from operating in thin area which usually had prior treatment with radiation and/or surgery. Over 60 transsternal radical neck dissections have been performed in the past 20 years. We have in the past evaluated the morbidity and survivals in stomal cases and present here our revised indications and techniques.
Melanoma of the head and neck
Authors: Conley John , Hamaker Ronald C. 
Published: October 2009

AbstractA retrospective review from 1935 to 1962 of 772 melanomas involving the head and neck seen at the Pack Medical Foundation (PMF) is presented with the main emphasis of 660 cutaneous and mucosal melanomas. Clark's levels for pathologic invasion are presented and correlated to 289 cases with 19 percent in Level II and 81 percent deeply invasive at Level III, IV, and V. The face was the most common location with the cheek alone accounting for 22.3 percent of all the cases. The male to female ratio was 1.5 to 1 with 76 percent of the cases being equally distributed among the fourth through the seventh decades. 55.9 percent were local disease, Stage I, with 33.5 percent, Stage II, and 10.6 percent, Stage III or distal disease.The five‐year or greater absolute cure rate in positive nodal disease was 12.6 percent. Elective versus no elective neck dissection in Stage IA disease demonstrated a five‐year or greater absolute cure rate of 55 percent as compared to 38.5 percent. Distal metastases occurred in 30 percent of cases with elective neck dissection but in 70 percent of those cases with therapeutic neck dissection. The absolute five‐year or greater cure rate was able to be analyzed in 556 cases. The rate was 25.6 percent for the mucosal and cutaneous lesions combined; an 8 percent rate for mucosal alone and 27.8 percent for cutaneous melanoma. The five‐year or greater absolute cure rate for those cases treated totally at PMF was 35.4 percent.
The applied anatomy of thyroglossal tract remnants
Authors: Ellis Peter D. M. , Van Nostrand A. W. Peter 
Published: October 2009

AbstractRecurrences after surgery for thyroglossal cysts and fistulas were common until, in 1920, Sistrunk described his technique for removing the whole thyroglossal tract. Since that time there has been considerable argument concerning the exact path taken by the tract particularly in relation to the hyoid bone.In an attempt to elucidate this problem, studies have been made of embryos at varying stages of development, of serially step‐sectioned adult larynges and of surgical specimens. These studies suggest that the thyroglossal tract occupies a constant and embryologically predictable position in relation to the hyoid bone and they support the rationale of Sistrunk's procedure.
Percutaneous embolization to control intractable epistaxis
Authors: Wills Paul I. , Russell Rex D. 
Published: October 2009

AbstractRecurrent epistaxis is a common manifestation of patients with a bleeding diathesis. Two patients with epistaxis secondary to a bleeding diathesis managed by local conservative techniques are reviewed. (A case of polycythemia vera and a case of liver failure secondary to hepatoma are reviewed.)Recently bilateral, percutaneous carotid angiography examination was performed on a patient with a bleeding diathesis and intractable epistaxis. At the time of the angiographic examination, embolization of both internal maxillary arteries with Gelfoam particles was accomplished and dramatic control of the epistaxis was achieved.In a patient with severe epistaxis secondary to a bleeding diathesis that is unresponsive to local measures, percutaneous Gelfoam embolization offers substantial advantages over surgical intervention.
Giant cell tumor of the ethmoid sinuses: Diagnostic dilemma
Authors: Burnam J. Andrew , Benson Jerome , Cohen Isaac 
Published: October 2009

AbstractTumors originating in the ethmoid sinuses are rare. Carcinomas of the ethmoid sinus, for example, comprise only 2‐3% of all head and neck malignancies. Of this small sample, the ethmoid sinuses as the primary site varies from 5‐30%. This paper presents the 14th documented case of giant cell tumor originating in the ethmoid sinuses. The pathology became the diagnostic dilemma; the case was originally diagnosed as an angiofibroma, later a reparative granuloma, and finally accepted as a giant cell tumor. The rationale for diagnosis and therapy is discussed.