bluuebunny/crossref_metadata_2025_split huggingface dataset:
Depression among people who live in coastal hazard areas in Indonesia: Evidence from a population-based national survey
Authors: Maharani Asri , Sujarwoto Sujarwoto , Susanti Herni , Brooks Helen , Bee Penny 
Published: June 2024

Abstract

Climate change has a profound impact on the mental health and well-being of people all over the world. However, studies on the impacts of climate-driven rising sea levels on mental health remain few. This study aims to examine the risk of depression among people who live in coastal areas susceptible to the natural hazards associated with climate change. We used the Indonesia Basic Health Survey 2018, which included 642,419 adults in Indonesia. Multivariable logistic regression analysis was conducted to examine the relationship between living in a coastal hazard area and depression. We included socio-demographics, health status, and health access information in the analysis to identify the most vulnerable groups. Our findings show that people who live in coastline hazard areas are 1.13 times more likely to have depression than people who live outside those areas. Individuals living in the coastal hazards areas who were less likely to have autonomous mobility or resources, including young adults, females, those with low socio-economic conditions, and those with pre-existing health conditions, had a higher risk of depression than other groups. Culturally acceptable and effective mental health interventions should thus target these vulnerable populations and settings to effectively reduce climate-related health risks.
Efficacy of DaXianXiong decoction in preventing the progression of severity of acute pancreatitis: Study protocol for a randomized controlled trial
Authors: Ren Dongsheng , Tan Judan , Lu Yun , Luo Zhenchun , Zhou Yuling , Liu Qinghai 
Published: June 2024

Abstract

Introduction: Developing countries are facing an increase in the incidence of acute pancreatitis (AP) — characterized by rapid onset, fast progression, high rate of severity, and high mortality. Progression of AP into severe acute pancreatitis (SAP) results in a series of complications such as organ dysfunction, local abscesses, pseudocysts, and necrosis. As no effective intervention measure has yet been developed, supportive therapy remains the major approach for the early treatment of AP. DaXianXiong decoction is a widely used TCM formulation; however, limited research is conducted on its clinical efficacy. Here, we propose a standardized clinical trial to evaluate the effectiveness and safety of DaXianXiong decoction in preventing the progression of AP to SAP.
Methods and analysis: This study is a randomized, double-blind, placebo-controlled, single-center clinical trial. Sixty eligible patients will be randomly allocated in a 1:1 ratio to the intervention group and the control group. Both groups will receive standard Western medical treatment for pancreatitis. However, the intervention group will additionally receive DaXianXiong decoction, while the control group will receive a placebo similar to the decoction. The primary outcomes will include incidence of SAP, modified CTSI score, APACHE II score, Modified Marshall score, and levels of the inflammation factor. The secondary outcomes will include the effect of the gastrointestinal dysfunction treatment. Evaluations will be conducted at baseline, 24 h after intervention, and days 3, 7, and 28 after intervention in both groups.
Discussion: This trial will help us assess the effectiveness and safety of DaXianXiong decoction in patients with AP.
Ethics and dissemination: Ethical approval was obtained from the Ethics Committee of the First Affiliated Hospital of Chongqing Traditional Chinese Medicine University (Ethical Review Number:2023-ky-51). The results of this study will be published in a peer-reviewed journal. The study sponsor does not have any role in study-related activities or in the final publication of the study.
Trial Registration: This trial is registered at the Chinese Clinical Trial Registry (http://www.chictr.org.cn/).Registration number: ChiCTR2300076885, Date: 2020-10-23, version 1.1.
The Research Trends of Post-operative Pediatric Cerebellar Mutism Syndrome: A Bibliometric Analysis (1999-2022)
Authors: Liang Qingtian , Wu Zuqing , Zhu Sihan , Du Yizhi , Cheng Zhuqing , Chen Yinsheng , Zhang Xiangheng , Lin Fuhua , Wang Jian 
Published: June 2024

Abstract

Background
Post-operative pediatric cerebellar mutism syndrome (ppCMS) is a common neurological complication characterized by delayed onset mutism, emotional lability, hypotonia, and oropharyngeal dysfunction following resection of a posterior fossa tumor in children. The objective of this study is to visually depict the knowledge structure and pinpoint research hotspots within the field using bibliometric analysis.
Method
Publications related to ppCMS from 1999 to 2022 were searched on the Web of Science Core Collection (WoSCC) database. VOSviewer, R package, “bibliometrix”, and CiteSpace were used to draw and analyze corresponding visualization maps.
Results
410 articles from 52 countries led by the United States of America (USA) and England were included. The number of published papers is on the rise in general. Hospital for Sick Children (Canada), St. Jude Children’s Research Hospital (USA), University Toronto (Canada), Texas Children’s Hospital (USA), and Children’s National Hospital (USA) are the main research institutions. Child’s Nervous System is the most popular and the most co-cited journal in this domain. These publications come from 2091 authors. Gajjar, A. has published the most papers, and the papers authored by Schmahmann, J.D. have been co-cited the most. The mechanisms, risk factors, and clinical manifestations of ppCMS occurrence and development are the main topics in this field. The most commonly used keywords are medulloblastoma, posterior fossa syndrome, cerebellar mutism, cerebellum, and children.
Conclusion
This is the first bibliometric analysis to comprehensively overview the active research areas and development of ppCMS, which will provide a reference for scholars studying this field.
Comparison between Micro- and Ultramini- Percutaneous Nephrolithotomy for the Treatment of 10-20 mm Kidney Stones in Preschool Children
Authors: Li Chenglong , Zhao Youquan , Wang Wenying , Li Jun , Tian Ye , Ning Chen 
Published: June 2024

Abstract

The incidence of kidney stones in children has steadily increased in recent years. Miniaturized percutaneous nephrolithotomy (PCNL) techniques, such as micro-PCNL and ultramini-PCNL, have become increasingly prevalent in pediatric kidney stone treatment due to their high stone clearance rate and low complication rate. In this study, we aim to compare the efficacy and safety of micro-PCNL and ultramini-PCNL in preschool children with 10–20 mm kidney stones. We conducted a retrospective analysis of data from 64 children under 6 years who received micro-PCNL and ultramini-PCNL surgeries in our hospital between January 2020 and January 2024. Patient demographics, stone characteristics, and intra/postoperative parameters were analyzed. There were 33 patients in micro-PCNL group and 31 patients in ultramini-PCNL group, with a mean age of 3.1 ± 1.3 years and 3.6 ± 1.8 years (p = 0.208), respectively. The stone size was 15 ± 4 mm in the micro-PCNL group and 16 ± 4 mm in the ultramini-PCNL group (p = 0.326). Micro-PCNL and ultramini-PCNL groups showed comparable stone free rates (84.8% vs. 87.1%, p = 0.796) and procedure times (49 ± 17 vs. 54 ± 23, p = 0.218). However, a significantly shorter hospitalization period was observed in the micro-PCNL group compared with the ultramini-PCNL group (2.3 ± 1.3 days vs. 4.6 ± 2.2 days, p < 0.001). Complications were similar between groups, with 12.4% in micro-PCNL group and 16.1% in ultramini-PCNL group and no severe hematuria was observed. In preschool children with 10–20 mm kidney stones, both micro-PCNL and ultramini-PCNL achieve similarly high stone-free rates with minimal complications. However, micro-PCNL, characterized by a smaller tract size, offers the additional advantage of shorter hospital stays.
CD8-positive T cells are key immune cells for predicting the therapeutic effect of neoadjuvant chemotherapy in triple-negative breast cancer
Authors: Uenaka Natsuki , Sato Eiichi , Horimoto Yoshiya , Kawai Saori , Asaoka Mariko , Kaise Hiroshi , Yamada Kimito , Ishikawa Takashi 
Published: June 2024

Abstract

Background
Patients with triple-negative breast cancer who obtain a pathological complete response after neoadjuvant chemotherapy have an improved prognosis. The existence of tumour-infiltrating lymphocytes (TILs) in breast cancer is also an independent prognostic factor, and lymphocyte-predominant breast cancer is more likely to respond to neoadjuvant chemotherapy. However, the detailed composition of immune cell infiltration in breast cancer and its relationship to the response to neoadjuvant chemotherapy has not been fully investigated.
Methods
The level of infiltration by immune cells expressing representative immune cell lineage surface markers in pre-treatment biopsy specimens from 52 patients with triple-negative breast cancer who received neoadjuvant chemotherapy and underwent curative surgery were examined by multispectral immunofluorescent labelling. The immune-related cell-surface markers, CD8, CD4, CD19, CD14, CD11c, and CD11b were selected. The numbers of infiltrating immune cells of each phenotype were counted and their association with pathological treatment response to neoadjuvant chemotherapy and patient outcome were analysed.
Results
The level of CD8-positive TIL infiltration was significantly higher in patients with a pathological complete response than in those without (P = 0.045). Although not statistically significant, stratified analysis showed high levels of CD8-positive TIL infiltration were associated with a high pathological complete response rate in the subgroup that also had high CD4-positive TIL infiltration. The Cox proportional hazard model revealed that only lymph node involvement was associated with disease-free survival (P = 0.008). The subgroup with high levels of CD8-positive TIL infiltration was related to a significantly prolonged disease-free survival in node-positive patients (P = 0.02), but not in node-negative patients (P = 0.73).
Conclusion
Our data suggest that assessing the infiltration of CD8-positive TILs in the primary tumour is a useful biomarker for prediction of pathological complete response after neoadjuvant chemotherapy and improved outcome in node-positive patients.
HTR1D regulates the PI3K/Akt signaling pathway to impact hepatocellular carcinoma development and resistance to sorafenib
Authors: Zhang Yingai , Zhang Yuting , Zhou Shuai , Rehman Mujeeb Ur , Lin Fankai , Zhang Jianquan , Zhou Hailong 
Published: June 2024

Abstract

Background Hepatocellular carcinoma (HCC) is a form of cancer with high incidence rates and low survival rates worldwide. Oral sorafenib is a promising therapy for advanced HCC, but resistance to the drug limits its effectiveness. HTR1D, a gene that is highly expressed in HCC, plays a crucial role in the development, drug resistance, and prognosis of the disease.Methods Firstly, the correlation between HTR1D and hepatocellular carcinoma was analyzed by TCGA database, and the expression level of HTR1D in clinical samples was detected by qPCR. Then the siRNA was transfected into HuH-7 and HEP3B cells, and the cell proliferation ability, colony formation ability, migration and invasion ability were detected with or without sorafenib. And the expression of PI3K/Akt pathway was detected by Western Blot. Finally, the potential of HTR1D as a predictive marker for patient prognosis was evaluated by immunohistochemistryResults Analysis of TCGA data showed that methylation of the HTR1D gene was associated with cancer status. Clinical samples confirmed significant differences in HTR1D expression between HCC and adjacent tissues, with higher expression correlating with poorer patient prognosis. Interference with HTR1D gene expression demonstrated its role in promoting HCC proliferation, migration, and drug resistance through the PI3K/Akt pathway. These findings were validated in a mouse model. Immunohistochemical analysis of clinicopathological samples suggested HTR1D could be a valuable prognostic marker for HCC.Conclusion HTR1D is highly expressed in hepatocellular carcinoma tissues, and it can influence hepatocellular carcinoma development and resistance to sorafenib by regulating the PI3K/Akt signaling pathway. In addition, HTR1D has potential as a prognostic indicator.
Spin and Orbital Magnetic Moments of UTe2 induced by the external magnetic field
Authors: Shick Alexander B. , Wdovik Urszula D. , Halevy Itzhak , Legut Dominik 
Published: June 2024

Abstract

Correlated band theory implemented as a combination of the relativistic density functional theory with exact diagonalization [DFT+U(ED)] of the Andersonimpurity term with Coulomb repulsion U in the 5f shell is applied to the magnetic field polarized state of UTe2. We demonstrate that the DFT+U(ED) approach provides a good agreement with very recent x-ray absorbtion near edge structure (XANES) and x-ray magnetic circular dichroism (XMCD) experiments. The branching ratio for the M4,5 edge transitions of uranium, and the valence spin-orbit interaction per hole were evaluated in a perfect agreement with the XANES. The orbital-to-spin moment ratio is calculated with DFT+U(ED) within the range of values extracted from XMCD data. The uranium atom 5f-shell ground state with 33 % of f2 and 58 % of f3 configurations is determined. Both XMCD and DFT+U(ED) point out the intermediate valence of uranium as well as itinerant-localized dichotomy in UTe2.
sVEGFR-3 alleviates myocardial ischemia/reperfusion injury through regulating mitochondrial homeostasis and immune cell infiltration
Authors: Shang Liqun , Ao Yuanhan , Huang Xiaolin , Wu Huawei , Feng Kangni , Wang Junjie , Yue Yuan , Zhou Zhuoming , Liu Quan , Li Huayang , Fu Guangguo , Liu Kaizheng , Pan Jinyu , Huang Yang , Chen Jiantao , Chen Guangxian , Liang Mengya , Yao Jianping , Huang Suiqing , Hou Jian , Wu Zhongkai 
Published: June 2024

Abstract

Recent studies have suggested that sVEGFR-3 is involved with cardiac disease by regulating lymphangiogenesis; however, results are inconsistent. The purpose of this study was to investigate the role and mechanism of sVEGFR-3 in myocardial ischemia/reperfusion injury (MI/RI). Plasma sVEGFR-3 levels were measured in patients with heart valve disease (HVD). sVEGFR-3 effects were evaluated in vivo in mice subjected to MI/RI, and in vitro using HL-1 cells exposed to hypoxia/reoxygenation. Echocardiography, TTC-Evans blue staining, ELISA, electron microscopy, immunofluorescence, Western blotting, and flow cytometry were used to investigate if sVEGFR3 attenuated I/R injury. TMT-based proteomics analysis was used to investigate the downstream mechanism of sVEGFR3. Results showed that plasma sVEGFR-3 levels were decreased in HVD patients compared to heathy control subjects. In patients undergoing cardiopulmonary bypass (CPB), sVEGFR-3 was significantly increased at 2 hours after release of the aortic cross-clamp and decreased slightly at 24 hours. In vivo, sVEGFR-3 pretreatment reduced cardiac dysfunction, infarct area, and myocardial injury indicators by reducing ROS production, apoptosis, and AIF expression. In vitro, sVEGFR-3 restored mitochondrial homeostasis by stabilizing the mitochondrial membrane potential (MMP) and preventing the opening of mitochondrial permeability transition pores (mPTP). And sVEGFR-3 inhibits mitochondrial apoptosis through the Ras/MEK/ERK pathway. Furthermore, I/R injury increased the proportion of M1 macrophages and CD4 + T cells in myocardial tissue, as well as serum IFN-γ and TNF-α levels, whereas sVEGFR-3 treatment attenuated these effects. sVEGFR-3 attenuates myocardial I/R injury by regulating mitochondrial homeostasis and immune cell infiltration, and reduces intrinsic ROS-mediated mitochondrial apoptosis via the Ras/MEK/ERK pathway.
Noninvasive uterine and umbilical blood flow changes and variates the expressions of angiogenic proteins and fetal growth: Behavioral study in pregnant Ossimi sheep
Authors: Elmetwally Mohammed A. , Adlan Fatma , Samy Alaa , Rezk Shaymaa , Lasheen Samah , Hendam Basma M. , Mohram Heba , Shalapy Sara , Fahmy Reham A , Mostagir Amira M. 
Published: June 2024

Abstract

The objective of this prospective study was to investigate whether Doppler- and B-mode sonography could be used to assess a possible influence of maternal temperament on fetal and pregnancy-related endpoints in sheep during pregnancy. On the basis of behavioral testing related to an anxiety-eliciting stimulus (arena test), 20 sheep were divided into two groups, namely more reactive/anxious (MR: 12 sheep) and less reactive/anxious (LR: 8 sheep). After mating, several endpoints were assessed by transrectal and/or transabdominal ultrasonography every 2 weeks (wk) from breeding to wk 20 of pregnancy and blood samples were taken to evaluate the expression of angiogenic proteins at parturition. Gestational length, fetal weight and fetal numbers were also investigated. The resistance index (RI), as well as the pulsatility index (PI) of the uterine (UtA) and the fetal umbilical arteries (UMA), were measured with non-invasive Doppler sonography. Further parameters were measured with B-mode ultrasonography: diameter of amniotic vesicles (AVD; only wk 2–8), umbilicus (UMD), fetal chest (FCHD), and metacarpal length (MCL). The UtA-PI was significantly higher in MR compared to LR ewes at pregnancy between 6–12 wks (P > 0.01), while a tendency was recognized at wk 14 (P = 0.054). The same was true for UtA-RI during the first 8 wk of pregnancy (P < 0.03) when MR and LR animals were compared. Similarly, UMA-RI was higher in fetuses of MR than LR ewes at wk 14 (P < 0.0003) and 20 (P < 0.02) of pregnancy. The differences in UMA-PI reached significance at wk 6, 8, 10, and 20 (P < 0.05–0.003). Furthermore, AVD (P < 0.03, wk 2–8), FCHD (P < 0.002, wk 8–18) as well as the UMD (P < 0.054, wk 8–18) were higher in LR than MR pregnant ewes. A significant variation in the gestational length, fetal weight and fetal numbers were recorded. The expressions of VEGF, NOS3 and VEGFR1 protein genes was increased in the less reactive sheep (P < 0.001). In conclusion, using Doppler- and B-mode sonography, the effects of maternal temperament on fetal growth, as well as maternal and umbilical blood flow in sheep could be successfully demonstrated. The maternal anxiety affects the expression of mRNAs for VEGF, NOS3 and HIF 1α at time of parturition.
Postural coping strategies of the active elderly on shoulder disturbance related to anterior falls
Authors: Dong Zheng , Song Ju-won , Shin Min-Ju , Im Du-Bin , Xu JiaHao , Wang XuanRu , Moon Young-Jin 
Published: June 2024

Abstract

Background: Static postural stability in older adults is often subject to external disturbances leading to sudden changes in balance. Understanding the ability of older adults who engage in regular physical activity to adjust and control their posture under static conditions will help to develop and promote strategies to reduce fall risk. This study examined the differential effects of regular physical activity on postural adjustment and control in older adults, focusing on responses to pre-shoulder barriers and visual conditions.Methods: Thirty participants were divided into two groups: 15 younger and 15 physically active older adults. The study assessed their postural responses to controlled anterior shoulder perturbations under different visual conditions. Muscle activation patterns and co-contraction rates were measured using electromyography, joint angle changes were analyzed using imaging techniques, and postural control was assessed using a force platform.Results: The active older participant group demonstrated better balance control and faster postural adjustment, with notable findings including improved use of compensatory postural adjustment strategies and reduced postural sway. Visual conditions significantly affected postural control strategies, with reduced visual input increasing thigh and trunk stiffness.Conclusions: Physically active older adults demonstrate good performance in response to a forward perturbation experiment. This study emphasizes that faster anticipatory postural adjustments in response to forward perturbations, reduced postural amplitude and increased joint stiffness are effective in reducing fall risk.
Engraftment of human mesenchymal stem cells in a severely immunodeficient mouse
Authors: Kato Yuko , Ito Ryoji , Taketani Takeshi , Matsuzaki Yumi , Miyagi Satoru 
Published: June 2024

Abstract

The transplantation of human mesenchymal stromal/stem cells (hMSCs) has potential as a curative and permanent therapy for congenital skeletal diseases. However, the self-renewal and differentiation capacities of hMSCs markedly vary. Therefore, cell proliferation and trilineage differentiation capacities were tested in vitro to characterize hMSCs before their clinical use. However, it remains unclear whether the ability of hMSCs in vitro accurately predicts that in living animals. The xenograft model is an alternative method for validating clinical MSCs. Nevertheless, the protocol still needs improvement and it has yet to be established whether hMSCs, which are expanded in culture for clinical use, retain the ability to engraft and differentiate into adipogenic, osteogenic, and chondrogenic lineage cells in transplantation settings. In the present study, to establish a robust xenograft model of MSCs, we examined the delivery routes of hMSCs and the immunological state of recipients. The intra-arterial injection of hMSCs into X-ray-irradiated (IR) NOG, a severely immunodeficient mouse, achieved the highest engraftment, but failed to sustain long-term engraftment. We demonstrated that graft cells localized to a collagenase-released fraction (CR), in which endogenous colony-forming cells reside. We also showed that Pdgfrα+Sca1+ MSCs (PαS), which reside in the CR fraction, resisted IR. These results show that our protocol enables hMSCs to fulfill a high level of engraftment in mouse bone marrow in the short term. In contrast, long-term reconstitution was restricted, at least partially, because of IR-resistant endogenous MSCs.
Psychometric Evaluation of Iranian Version of Beliefs about Third-Hand Smoke Scale (BATHS-T) in Pregnant Women
Authors: Khodayarian Mahsa , Youshani Nooshin , Jambarsang Sara , Pourmovahed Zahra , Kakolaki Zohreh Karimian 
Published: June 2024

Abstract

Introduction:
Exposure to third-hand smoke (THS) is hazardous for human health, especially for pregnant women. This study aimed at psychometric evaluation of the Iranian version of “Beliefs about Third-Hand Smoke Scale”(BATHS-T) in pregnant women.
Aims & Methods:
The data collected from 364 pregnant women referring to Yazd health centers. The BATHS scale was translated into Persian, and the stages of adaptation of the BATHS scale in Persian were evaluated with CVR = 0.87 and CVI = 0.88. Confirmatory factor analysis (CFA) was performed to analyze the construct validity of the scale. Besides, the correlation test was used to evaluate the correlation of categories and subcategories of the scale.
Results
The BATHS structural equation model showed a favorable fit as RMSEA value was less than 0.05 and X2/df varied between 2 to 5. Moreover, other indices such as CFI and NFI were more than 90%, indicating the optimal fit of the present model. The correlation between the overall scale of BATHS and its two subcategories was 0.843 (P < 0.001) and the correlation between health and stability subcategories was 0.886 (P < 0.001). Since there was a positive and highly significant correlation, the fitted BATHS scale was considered to be structurally consistent with its subcategories. The reliability of the whole scale was 0.86 using Cronbach's α coefficient.
Conclusion
The Iranian version of the BATHS scale is reliable and valid. This scale provides the required prerequisites for further research and education on third hand smoke exposure. It can also be possibly used in similar studies.