bluuebunny/crossref_metadata_2025_split huggingface dataset:
STRATEGI PENGEMBANGAN USAHA KOPI BUBUK CAP BUKIT ASAM DI KABUPATEN MUARA ENIM, SUMATERA SELATAN
Authors: Purwati Dinda , Sekar Tanjung Garist , Djazuli R. Achmad 
Published: May 2024

Minum kopi sudah menjadi budaya masyarakat Indonesia, baik kalangan orang tua maupun anak muda. Kondisi itu mendorong munculnya banyak pelaku usaha produksi kopi bubuk. Salah satunya Kopi Bubuk Cap Bukit Asam yang berada di Tanjung Enim, Kabupaten Muara Enim, Sumatera Selatan. Tujuan penelitian ini untuk menganalisa tren perkembangan produksi dan penjualan Kopi Bubuk Cap Bukit Asam selama 5 tahun terakhir, mengetahui pengaruh faktor internal dan eksternal perusahaan serta merumuskan alternatif strategi pengembangan usaha. Teknik penelitian menggunakan analisa tren dan analisa SWOT. Hasil penelitian menunjukkan, tren perkembangan produksi dan penjualan Kopi Bubuk Cap Bukit Asam selama 5 tahun terakhir cenderung mengalami kenaikan. Strategi yang tepat untuk pengembangan usaha ini yaitu menggunakan strategi agresif dengan beberapa alternatif, yaitu memperluas serta memperkuat jaringan pasar, menerapkan strategi promosi, perbaikan dan peningkatan sistem pemasaran dan memperkuat promosi, mencari modal tambahan, melakukan penerapan standar mutu produk, memperkuat produk yang dihasilkan dengan legalitas usaha, memanfaatkan perkembangan teknologi untuk mengatasi promosi, dan menjalin hubungan yang baik dengan pelanggan agar tercipta loyalitas pelanggan.
Drinking coffee has become a culture of Indonesian society, both among old people and young people. This condition has encouraged the emergence of many ground coffee production businesses. One of them is Bukit Asam Cap Coffee Powder which is located in Tanjung Enim, Muara Enim Regency, South Sumatra. The aim of this research is to analyze the development trends in production and sales of Bukit Asam Cap Coffee Powder over the last 5 years, determine the influence of internal and external factors on the company and formulate alternative business development strategies. The research technique used trend analysis and SWOT analysis. The research results show that the development trend of production and sales of Cap Bukit Asam Ground Coffee over the last 5 years has tended to increase. The right strategy for developing this business is to use an aggressive strategy with several alternatives, namely expanding and strengthening the market network, implementing promotional strategies, improving and upgrading the marketing system and strengthening promotions, seeking additional capital, implementing product quality standards, strengthening the products produced by business legality, utilizing technological developments to handle promotions, and establishing good relationships with customers to create customer loyalty.
Hubungan Karakteristik Dan Kepuasan Ibu Hamil Dengan Motivasi Melakukan Antenatal Care Di Puskesmas Pelambuan Banjarmasin
Authors: Oktari Ida Ayu , Rahayu Yayuk Puji , Sukamto Sukamto 
Published: May 2024

Latar Belakang: Pasien atau Klien yang datang ke pelayanan Kesehatan dipengaruhi banyak factor, hal ini tentu tidak terlepas dari karakteristik yang berbeda-beda dari segi umur, tingkat Pendidikan, jenis pekerjaan, dan kepuasan serta motivasi yang berbeda dalam ketersedian ibu hamil untuk datang ke pelayanan Kesehatan. Interaksi factor-faktor tersebut akan memperngaruhi motivasinya untuk Kembali ke tempat pelayanan Kesehatan, selanjutnya akan diteliti hubungan karakteristik dan Kepuasan ibu hamil dengan motivasi melakukan Antenatal care di Puskesmas Pelambuan Banjarmasin. Tujuan: Mengetahui hubungan karakteristik dan kepuasan ibu hamil dengan motivasi melakukan Antenatal care di Puskesmas Pelambuan Banjarmasin. Metode: metode penelitian yang digunakan yaitu metode survei analitik dengan rancangan cross sectional. Hasil: Analisis Uji Fisher’s Exact test untuk hubungan karakteristik umur ibu hamil dengan motivasi adalah 1.000. Nilai signifikan tersebut lebih besar dibandingkan dari taraf signifikan 0,05 sehingga dinyatakan bahwa tidak ada hubungan yang bermakna antara variabel karakteristik (umur, Pendidikan, pekerjaan) dan kepuasan ibu hamil dengan motivasi melakukan Antenatal care di Puskesmas Pelambuan Banjarmasin. Kesimpulan: Disadari bahwa faktor yang berhubungan dengan motivasi melakukan Antenatal care banyak, variabel lain mungkin mempengaruhi motivasi ibu hamil antara lain pengetahuan, sikap, kepercayaan dan tingkat social ekonomi
Intervensi untuk Menurunkan Kebisingan di Neonatal Intensive Care Unit (NICU): Systematic Review
Authors: Nadi Hartin I.K. , Allenidekania Allenidekania , Rustina, S.Kp., M.App.Sc., Ph.D Prof. Yeni 
Published: May 2024

Latar Belakang: Paparan kebisingan di NICU yang tidak terhindarkan dikaitkan dengan peningkatan stres, peningkatan respons fisiologis dan perilaku tidur terjaga yang pada akhirnya berdampak pada perkembangan bayi prematur. Tujuan: Studi ini bertujuan untuk mengevaluasi efektivitas berbagai intervensi untuk menurunkan kebisingan di NICU dan mengidentifikasi peluang untuk dilakukan penelitian lebih lanjut. Metode: Fokus studi pada intervensi dengan desain randomized controlled trials (RCTs) dan quasy experiment. Metode pencarian artikel dilakukan pada enam database dari ProQuest, ScienceDirect, PubMed, Scopus, Embase, dan MEDLINE serta pencarian secara manual melalui daftar referensi artikel yang relevan. Studi dipilih berdasarkan kriteria inklusi yaitu tempat di ruang NICU, intervensi untuk mengurangi kebisingan lingkungan, artikel full text, berbahasa Inggris, artikel dipublikasi tahun 2013-2023 dan hasil ukur dalam desibel (dBA). Semua penulis dalam studi ini secara independen menilai daftar artikel dan abstrak yang relevan, melakukan ekstraksi data dan melakukan penilaian kualitas metode penelitian dengan pedoman Joanna Briggs Institute (JBI). Hasil: Studi ini menganalisis 10 artikel yang memenuhi kriteria inklusi dan eksklusi. Studi yang disertakan secara keseluruhan memiliki risiko bias yang moderate. Intervensi yang dapat menurunkan kebisingan di NICU meliputi program pendidikan, multikomponen perangkat peringatan dan intervensi yang berhubungan dengan pasien seperti penggunaan earplug dan penutup inkubator pada bayi prematur. Kesimpulan: Program pendidikan dan multikomponen merupakan intervensi yang paling efektif untuk menurunkan tingkat kebisingan. Intervensi seperti penggunaan earplug maupun penutup inkubator dapat menurunkan tingkat kebisingan namun penurunan tersebut tidak signifikan secara statistik sehingga diperlukan penelitian berkualitas tinggi dengan risiko bias rendah dan tindak lanjut jangka panjang.
Penciptaan Tari Calengsai Karya Rianto
Authors: Saputri Willia dwi , Kuncoro Jonet Sri 
Published: May 2024

ABSTRACT Calengsai is an acronym for the words Calung, Lengger, and Barongsai. The Calengsai dance depicts a cultural journey between China and Banyumas. with the existence of Calung, Lengger and Barongsai which were worked on, developed and acculturated so as to produce a new dance work entitled Calengsai dance which was staged in the Lengger Metamorphosis show. Rianto's Calengsai dance is a new dance creation, a development of Sri Rahayu's Calengsai dance. Rianto developed the Calengsai dance from the form of a calengsai dance performance with the addition of a Chinese singer, Barongan Banyumas and a buffalo-headed dancer called Rajamala.This research is based on the formulation of the problem how the form of the Calengsai dance by Rianto and how the creation of the Calengsai dance by Rianto uses the theoretical basis of the form expressed by Slamet MD and the creation of dance by Slamet MD which was examined using qualitative research methods with an interactive approach that is descriptive analytical with the data collection stages are field observations, interviews, documentation, and library researchThe results obtained show that the Calengsai dance by Rianto is a form of acculturation of two Javanese and Chinese cultures, the form of which is embodied in Calung Lengger, Barongsai and Barongan Banyumas which follow the motions of the Banyumasan tradition developed by Rianto, the creator through a process of observation, exploration , experimentation, formation and training of dancers. KEY WORDS : Calengsai Dance, Problem Formulation, Theory Basis
أثر التغذية الراجعة السمعية المباشرة في تعلم الأداء الفني للسباحة الحرة للمبتدئين
Authors: Hushyar Omar Hussein  , Prof. Dr. . Kazhal Kaka Hama Saeed  
Published: May 2024

تهدف الدراسة الى معرفة أثر التغذية الراجعة باستخدام اﻹتصال اللاسلكي المائي في تعلم الأداء الفني للسباحة الحرة للمبتدئين. استخدم الباحثان المنهج التجريبي لملائمة طبيعة المشكلة وهدف البحث ، تمثلت مجتمع البحث المشاركين في الدورة الصيفية لتعليم سباحة في مسبح (سبورت سنتر) بقضاء (كلار) والبالغ عددهم (27) طفلا ، أما عينة البحث فقد كان عددهم (20) طفلاً يتراوح أعمارهم من (10-12) سنة ، إذ بلغت النسبة المئوية للعينة (74% ) من مجتمع الأصل , وبناءا على خصائص عينة البحث قام الباحث بتقسيم أفراد عينة البحث على مجموعتين متجانستين بطريقة القرعة ، وكل مجموعة تتكون من (10) طفل مبتدأ لمجموعتي البحث، المجموعة (أ) التجريبية والمجموعة (ب)الضابطة ولا يستطيعون أداء السباحة اطلاقا .وقد استنتج الباحثان :

التغذية الراجعة السمعية المباشرة باستخدام تقنية الاتصال اللاسلكي المائي لها تأثير فعال في تعلم الأداء الفني للسباحة الحرة.
تفوق أفراد المجموعة التجريبية على أفراد المجموعة الضابطة في اختبار الأداء الفني لسباحة الحرة.
Pengaruh Pembelajaran Daring Terhadap Kemandirian Belajar Dimoderasi oleh Self Efficacy (Studi Kasus Pada SMA Kristen Petra Kefamenanu)
Authors: Salsinha Cecilia Novianti , Bete Hendrika , Binsasi Eva 
Published: May 2024

Penelitian ini bertujuan untuk mengetahui pengaruh pembelajaran daring yang telah dialami oleh siswa terhadap kemandirian belajar siswa melalui self efficacy matematis. Penelitian ini merupakan penelitian kuantitatif yang menggunakan analisis jalur dalam proses pengolahan data. Disamping itu penggunaan analisis regresi sederhana dan berganda tetap digunakan mengingat terdapat variabel intervening sehingga memungkinkan penggunaan analsisis regresi. Data diperoleh melalui angket yang kemudian diolah untuk menjawab beberapa rumusan masalah yang berkaitan dengan implementasi pembelajaran daring, pengaruhnya pada kemandirian belajar melalui self efficacy matematis siswa. Sampel pada penelitian ini yaitu siswa SMA Kristen Petra Kefamenanu khususnya kelas XI yang terdiri dariÂ 44 orang. Hasil penelitian menunjukkan bahwaÂ pengaruhÂ paling besar adalah pengaruh bersama Pembelajaran Daring dan Self Efficacy terhadap Kemandirian Belajar sebesar 51%, diikuti oleh pengaruh secara langsung Self Efficacy terhadap Kemandirian Belajar sebesar 44,7% dan pengaruh secara langsung Pembelajaran Daring Terhadap Self Efficacy sebesar 38,6% serta pengaruhÂ secara langsung pembelajaran daring terhadap terhadap kemandirian belajar yaitu sebesar 37,6%. Hal yang menarik adalah bahwa kemandirian belajar siswa akan meningkat jika pembelajaran daring dilakukan dengan menekankan pada self efficacy matematis siswa.
Clinical efficacy of different androgen deprivation therapies for prostate cancer and evaluation based on dynamic-contrast enhanced magnetic resonance imaging
Authors: Guo WenXiao , Li MengZhu 
Published: May 2024

ObjectiveTo evaluate the clinical efficacy of different androgen deprivation therapies for prostate cancer (PCa) based on dynamic-contrast enhanced magnetic resonance imaging (DCE-MRI).Methods104 patients with PCa were studied, all of whom were treated with androgen deprivation therapy. The patients were divided into a continuous group (continuous androgen deprivation therapy) and an intermittent group (intermittent androgen deprivation therapy) by random number table method, 52 cases/group. The therapeutic effect and DCE-MRI indices were compared and the relationship between DCE-MRI indices and clinical efficacy and the evaluation value of therapeutic efficacy were analyzed.ResultsThe objective response rate (ORR) of the intermittent group was higher than that of the continuous group (p &lt; 0.05), and there was no significant difference in disease control rate (DCR) between the two groups (p &gt; 0.05). After treatment, volume transfer coefficient (Ktrans), reverse transfer constant (Kep), volume fraction (Ve), blood volume (BV), and blood flow (BF) in both groups were lowered, and those in the intermittent group were lower than the continuous group (p &lt; 0.05). Ktrans, Kep, Ve, BF, and BV in the ORR group were lower than those in the non-ORR group (p &lt; 0.05). Ktrans, Kep, Ve, BF, and BV were correlated with the therapeutic effect of PCa (p &lt; 0.05). The AUC value of the combined detection of DCE-MRI indices in evaluating the therapeutic effect of PCa was greater than that of each index alone (p &lt; 0.05).ConclusionCompared with continuous androgen deprivation therapy, intermittent androgen deprivation therapy has better clinical efficacy in the treatment of PCa, and DCE-MRI indices are related to the treatment efficacy of PCa and have an evaluation value.
Interacting and joint effects of triglyceride-glucose index and hypertension on stroke risk in middle-aged and older Chinese adults: a population-based prospective cohort study
Authors: Luo Yun-Dan , Gan Ying-Yuan , Liao Qian , Li Xu , Huo Rong-Rui 
Published: May 2024

BackgroundTriglyceride-glucose (TyG) index and hypertension were well-established risk factors for stroke. And TyG index was associated with hypertension. However, no prior study has investigated the interactive effects of the TyG index and hypertension on stroke. This study examined whether hypertension mediates associations of TyG index with incident stroke and the extent of interaction or joint relations of TyG index and hypertension with stroke in middle-aged and older Chinese adults.MethodsThe China Health and Retirement Longitudinal Study (CHARLS) is an ongoing nationally representative prospective cohort study initiated in 2011. This cohort study included 9,145 middle-aged and older Chinese adults without stroke at baseline. The eposures were TyG index and the logarithmized product of hypertension, as determined during the baseline health examination. The main outcome was self-reported physician-diagnosed stroke which followed up from June 1, 2011, to June 30, 2018.ResultsOf the 9,145 participants, 4,251 were men (46.5%); the mean (SD) age was 59.20 (9.33) years. During a median follow-up of 7.1 years, 637 (7.0%) participants developed stroke. In multivariable-adjusted models, the TyG index was significantly associated with the risk of hypertension [odds ratio (OR) per 1-SD increase, 1.29; 95% CI, 1.19–1.41] and stroke [hazard ratio (HR) per 1-SD increase, 1.16; 95% CI, 1.02–1.33]. Both multiplicative and additive interactions were observed between TyG index and hypertension on stroke (HR for multiplicative: 2.34, 95% CI, 1.57–3.48; Synergy index: 4.13, 95% CI, 2.73–6.25). Mediation analysis showed that 20.0% of the association between TyG index and stroke was mediated through hypertension.ConclusionsThis study suggests a synergistic effect of TyG index and hypertension on stroke, and a small proportion of the association between TyG index and stroke was mediated by hypertension, indicating the benefit of coordinated control strategies for both exposures.
Pre-existing cell populations with cytotoxic activity against SARS-CoV-2 in people with HIV and normal CD4/CD8 ratio previously unexposed to the virus
Authors: Casado-Fernández Guiomar , Cantón Juan , Nasarre Laura , Ramos-Martín Fernando , Manzanares Mario , Sánchez-Menéndez Clara , Fuertes Daniel , Mateos Elena , Murciano-Antón María Aranzazu , Pérez-Olmeda Mayte , Cervero Miguel , Torres Montserrat , Rodríguez-Rosado Rafael , Coiras Mayte 
Published: May 2024

IntroductionHIV-1 infection may produce a detrimental effect on the immune response. Early start of antiretroviral therapy (ART) is recommended to preserve the integrity of the immune system. In fact, people with HIV (PWH) and normal CD4/CD8 ratio appear not to be more susceptible to severe forms of COVID-19 than the general population and they usually present a good seroconversion rate in response to vaccination against SARS-CoV-2. However, few studies have fully characterized the development of cytotoxic immune populations in response to COVID-19 vaccination in these individuals.MethodsIn this study, we recruited PWH with median time of HIV-1 infection of 6 years, median CD4/CD8 ratio of 1.0, good adherence to ART, persistently undetectable viral load, and negative serology against SARS-CoV-2, who then received the complete vaccination schedule against COVID-19. Blood samples were taken before vaccination against COVID-19 and one month after receiving the complete vaccination schedule. ResultsPWH produced high levels of IgG against SARS-CoV-2 in response to vaccination that were comparable to healthy donors, with a significantly higher neutralization capacity. Interestingly, the cytotoxic activity of PBMCs from PWH against SARS-CoV-2-infected cells was higher than healthy donors before receiving the vaccination schedule, pointing out the pre-existence of activated cell populations with likely unspecific antiviral activity. The characterization of these cytotoxic cell populations revealed high levels of Tgd cells with degranulation capacity against SARS-CoV-2-infected cells. In response to vaccination, the degranulation capacity of CD8+ T cells also increased in PWH but not in healthy donors.DiscussionThe full vaccination schedule against COVID-19 did not modify the ability to respond against HIV-1-infected cells in PWH and these individuals did not show more susceptibility to breakthrough infection with SARS-CoV-2 than healthy donors after 12 months of follow-up. These results revealed the development of protective cell populations with broad-spectrum antiviral activity in PWH with normal CD4/CD8 ratio and confirmed the importance of early ART and treatment adherence to avoid immune dysfunctions.
A potential defensive role of TIM-3 on T lymphocytes in the inflammatory involvement of diabetic kidney disease
Authors: Chen Xiao-Jun , Tang Runyan , Zha Jie , Zeng Li , Zhou Linshan , Liu Zhiwen , Yang Danyi , Zeng Mengru , Zhu Xuejing , Chen Anqun , Liu Hong , Chen Huihui , Chen Guochun 
Published: May 2024

ObjectiveThe aberrant mobilization and activation of various T lymphocyte subpopulations play a pivotal role in the pathogenesis of diabetic kidney disease (DKD), yet the regulatory mechanisms underlying these processes remain poorly understood. Our study is premised on the hypothesis that the dysregulation of immune checkpoint molecules on T lymphocytes disrupts kidney homeostasis, instigates pathological inflammation, and promotes DKD progression.MethodsA total of 360 adult patients with DKD were recruited for this study. The expression of immune checkpoint molecules on T lymphocytes was assessed by flow cytometry for peripheral blood and immunofluorescence staining for kidney tissue. Single-cell sequencing (scRNA-seq) data from the kidneys of DKD mouse model were analyzed.ResultsPatients with DKD exhibited a reduction in the proportion of CD3+TIM-3+ T cells in circulation concurrent with the emergence of significant albuminuria and hematuria (p=0.008 and 0.02, respectively). Conversely, the incidence of infection during DKD progression correlated with an elevation of peripheral CD3+TIM-3+ T cells (p=0.01). Both univariate and multivariate logistic regression analysis revealed a significant inverse relationship between the proportion of peripheral CD3+TIM-3+ T cells and severe interstitial mononuclear infiltration (OR: 0.193, 95%CI: 0.040,0.926, p=0.04). Immunofluorescence assays demonstrated an increase of CD3+, TIM-3+ and CD3+TIM-3+ interstitial mononuclear cells in the kidneys of DKD patients as compared to patients diagnosed with minimal change disease (p=0.03, 0.02 and 0.002, respectively). ScRNA-seq analysis revealed decreased gene expression of TIM3 on T lymphocytes in DKD compared to control. And one of TIM-3's main ligands, Galectin-9 on immune cells showed a decreasing trend in gene expression as kidney damage worsened.ConclusionOur study underscores the potential protective role of TIM-3 on T lymphocytes in attenuating the progression of DKD and suggests that monitoring circulating CD3+TIM3+ T cells may serve as a viable strategy for identifying DKD patients at heightened risk of disease progression.
IL-2Rα KO mice exhibit maternal microchimerism and reveal nuclear localization of IL-2Rα in lymphoid and non-lymphoid cells
Authors: Wong Victoria A. , Dinh Kristie N. , Chen Guangchun , Wrenshall Lucile E. 
Published: May 2024

IntroductionIL-2Rα knock out (KO) mice have been instrumental to discovering the immunoregulatory properties of IL-2Rα. While initially thought of only as a stimulatory cytokine, IL-2 and IL-2Rα KO mice revealed that this cytokine-receptor system controls immune responses through restimulation-induced cell death and by promoting the survival of T regulatory cells. Although described mostly in the context of lymphocytes, recent studies by our laboratory showed that IL-2R is expressed in smooth muscle cells. Given this finding, we sought to use IL-2Rα KO to determine the function of this receptor in vascular smooth muscle cells. Surprisingly, we found that IL-2Rα KO vascular smooth muscle cells had detectable IL-2Rα.MethodsWe used multiple gene and protein-based methods to determine why IL-2Rα KO vascular smooth muscle cells exhibited IL-2Rα protein. These methods included: genomic sequencing, assessing cells and tissues for evidence of maternal microchimerism, and determining the half-life of IL-2Rα protein.ResultsOur studies demonstrated the following: (1) in addition to the cell surface, IL-2Rα is localized to the nucleus; (2) the genetic deletion of IL-2Rα is intact in IL-2Rα KO mice; (3) both IL-2Rα KO and WT tissues show evidence of maternal microchimerism, the likely source of IL-2Rα (4) IL-2Rα is transmitted between cells; (5) IL-2Rα has a long half-life; and (6) nuclear IL-2Rα contributes to the regulation of cell proliferation and size.ConclusionOur findings suggest that the phenotype of complete IL-2Rα loss is more severe than demonstrated by IL-2Rα KO mice, and that IL-2Rα plays a here-to-fore unrecognized role in regulating cell proliferation in non-lymphoid cells.