bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between underweight, serum albumin levels, and height loss in the Japanese male population: a retrospective study
Authors: Shimizu Yuji , Honda Eiko , Sasaki Nagisa , Takada Midori , Yoshida Tomokatsu , Motomura Kazushi 
Published: May 2024

Abstract
Background
Previous study has shown that height loss (defined as the highest quartile of height loss per year) was inversely associated with serum albumin levels. Furthermore, comparatively healthy hyponutrition has been linked with being underweight; as such, underweight might be inversely associated with serum albumin levels and positively associated with height loss.

Methods
To clarify the associations between serum albumin level, underweight status, and height loss, we conducted a retrospective study of 8,096 men over 4.0 years (median).

Results
Serum albumin level at baseline was inversely associated with being underweight (body mass index [BMI]: < 18.5 kg/m2) at baseline and height loss. The known cardiovascular risk factor adjusted odds ratio (OR) and 95% confidence interval (CI) of underweight at baseline and of height loss for 1 standard deviation increment of serum albumin (0.28 g/dL) was 0.79 (0.70, 0.90) and 0.84 (0.80, 0.88). Underweight was also shown to be positively associated with height loss: with the reference of normal-low weight (BMI: 18.5–22.9 kg/m2), the adjusted OR (95% CI) was 1.60 (1.21, 2.10).

Conclusion
Comparative healthy hyponutrition, which is related to low serum albumin levels and being underweight, is a significant risk factor for height loss among Japanese men. These results help to clarify the mechanisms underlying height loss.
Evolutionary and functional analyses of LRP5 in archaic and extant modern humans
Authors: Roca-Ayats Neus , Maceda Iago , Bruque Carlos David , Martínez-Gil Núria , Garcia-Giralt Natàlia , Cozar Mónica , Mellibovsky Leonardo , Van Hul Wim , Lao Oscar , Grinberg Daniel , Balcells Susanna 
Published: May 2024

Abstract
Background
The human lineage has undergone a postcranial skeleton gracilization (i.e. lower bone mass and strength relative to body size) compared to other primates and archaic populations such as the Neanderthals. This gracilization has been traditionally explained by differences in the mechanical load that our ancestors exercised. However, there is growing evidence that gracilization could also be genetically influenced.

Results
We have analyzed the LRP5 gene, which is known to be associated with high bone mineral density conditions, from an evolutionary and functional point of view. Taking advantage of the published genomes of archaic Homo populations, our results suggest that this gene has a complex evolutionary history both between archaic and living humans and within living human populations. In particular, we identified the presence of different selective pressures in archaics and extant modern humans, as well as evidence of positive selection in the African and South East Asian populations from the 1000 Genomes Project. Furthermore, we observed a very limited evidence of archaic introgression in this gene (only at three haplotypes of East Asian ancestry out of the 1000 Genomes), compatible with a general erasing of the fingerprint of archaic introgression due to functional differences in archaics compared to extant modern humans. In agreement with this hypothesis, we observed private mutations in the archaic genomes that we experimentally validated as putatively increasing bone mineral density. In particular, four of five archaic missense mutations affecting the first β-propeller of LRP5 displayed enhanced Wnt pathway activation, of which two also displayed reduced negative regulation.

Conclusions
In summary, these data suggest a genetic component contributing to the understanding of skeletal differences between extant modern humans and archaic Homo populations.
Hindsight to foresight: an AI-powered analysis of future events in EJFR in 10 years
Authors: Barbosa Carlos Eduardo , Lyra Alan , de Souza Jano Moreira , Lima Yuri , Salazar Herbert , Argôlo Matheus 
Published: May 2024

AbstractThe world is changing increasingly faster, bringing uncertainty and complexity to many processes, and this acceleration leads to the rise of demand for studies regarding the future. Futures Studies have been widely used to support decision-making, emphasizing forecasting technologies’ timing, diffusion, and life cycle. Therefore, evaluating previous forecasts to understand their proposed scenarios better is often necessary. This work analyzes all articles published until the end of 2023 in one of the most relevant journals of this field of study, the European Journal of Futures Research (EJFR). The EJFR is among the main contributors to fostering dialogue among scholars, practitioners, and policymakers interested in anticipating and shaping the future. We streamlined the uncovering of future events written on EJFR articles using NERMAP, a software we designed to semi-automate the roadmapping process. We built five simple scenarios and associated each of the 214 future events found into a scenario. Then, we analyzed the 52 events that were supposed to happen until 2023 to discover how the expected possible events did occur in real life. Therefore, we expect to provide insights, better understand how expected possible events occur in real life, and write a novel way to understand the journal’s history. The methodology used in this study is novel and applicable to other studies to reduce the time and risk of errors when developing large-scale roadmaps. This work provides valuable information for decision-makers in organizations and governments. The Futures Research scientific community can use the results to improve their research frameworks.
Associations between medical students’ stress, academic burnout and moral courage efficacy
Authors: Neufeld-Kroszynski Galit , Michael Keren , Karnieli-Miller Orit 
Published: May 2024

Abstract
Background
Medical students, especially during the clinical years, are often exposed to breaches of safety and professionalism. These contradict personal and professional values exposing them to moral distress and to the dilemma of whether and how to act. Acting requires moral courage, i.e., overcoming fear to maintain one’s core values and professional obligations. It includes speaking up and “doing the right thing” despite stressors and risks (e.g., humiliation). Acting morally courageously is difficult, and ways to enhance it are needed. Though moral courage efficacy, i.e., individuals’ belief in their capability to act morally, might play a significant role, there is little empirical research on the factors contributing to students’ moral courage efficacy. Therefore, this study examined the associations between perceived stress, academic burnout, and moral courage efficacy.

Methods
A cross-sectional study among 239 medical students who completed self-reported questionnaires measuring perceived stress, academic burnout (‘exhaustion,’ ‘cynicism,’ ‘reduced professional efficacy’), and moral courage efficacy (toward others’ actions and toward self-actions). Data analysis via Pearson’s correlations, regression-based PROCESS macro, and independent t-tests for group differences.

Results
The burnout dimension of ‘reduced professional efficacy’ mediated the association between perceived stress and moral courage efficacy toward others’ actions. The burnout dimensions ‘exhaustion’ and ‘reduced professional efficacy’ mediated the association between perceived stress and moral courage efficacy toward self-actions.

Conclusions
The results emphasize the importance of promoting medical students’ well-being—in terms of stress and burnout—to enhance their moral courage efficacy. Medical education interventions should focus on improving medical students’ professional efficacy since it affects both their moral courage efficacy toward others and their self-actions. This can help create a safer and more appropriate medical culture.
The predicting factors of chronic pain among nursing students: a national study in Iran
Authors: Shaygan Maryam , Tehranineshat Banafsheh , Teshnizi Saeed Hosseini , Mohammadi Agrin 
Published: May 2024

Abstract
Background
Nursing students are faced with a variety of challenges that demand effective cognitive and emotional resources. The physical and psychological well-being of the students plays a key part in the public health of the community. Despite the special lifestyle of nursing students, few studies have addressed chronic pain in this population. Accordingly, the present study aims to identify the predictors of chronic pain among nursing students.

Methods
This cross-sectional study was conducted on 1,719 nursing students aged 18–42 years, between February and November 2019. Sampling was carried out in several stages. Data were collected using seven instruments, namely a demographics survey, the characteristics of chronic pain form, Spielberger State-Trait Anxiety Inventory (STAI), the Patient Health Questionnaire-9 (PHQ-9), the Bar-on Emotional Quotient Inventory, Academic Satisfaction Scale, and Procidano and Heller Social Support Scale. Descriptive statistics, multinomial logistic regression, and regression models were used to describe the characteristics of the pain and its predictive factors.

Results
The average age of the participants was 22.4 ± 2.96 years. The results of univariate analysis showed that gender (P = 0.506), mother’s education (P = 0.056, P = 0.278, P = 0.278), father’s education (P = 0.817, P = 0.597, P = 0.41), place of residence (P = 0.215), depression (P = 0.501), grade point average (P = 0.488), academic satisfaction (P = 0.183) and chronic pain weren’t significantly correlated with chronic pain in nursing students. The results of the multiple logistic regression models showed that chronic pain was positively correlated with age, social support, state anxiety, and trait anxiety (OR = 1.07, 95% CI: 1.02–1.12; OR = 0.95, 95% CI: 0.93–0.97; OR = 1.03, 95% CI: 1.02–1.05; and OR = 1.97, 95% CI: 0.95–1.99; respectively).

Conclusion
The prevalence of chronic pain was relatively high in these students. In addition, age, social support, and anxiety could be important factors in the development or persistence of chronic pain in nursing students. The results also provided basic and essential information about the contributing factors in this area. However, consideration of factors such as referral for treatment, home medications for pain relief, and outcomes of chronic pain are suggested in future longitudinal studies.
7 Tesla magnetic resonance spectroscopic imaging predicting IDH status and glioma grading
Authors: Cadrien Cornelius , Sharma Sukrit , Lazen Philipp , Licandro Roxane , Furtner Julia , Lipka Alexandra , Niess Eva , Hingerl Lukas , Motyka Stanislav , Gruber Stephan , Strasser Bernhard , Kiesel Barbara , Mischkulnig Mario , Preusser Matthias , Roetzer-Pejrimovsky Thomas , Wöhrer Adelheid , Weber Michael , Dorfer Christian , Trattnig Siegfried , Rössler Karl , Bogner Wolfgang , Widhalm Georg , Hangel Gilbert 
Published: May 2024

Abstract
Introduction
With the application of high-resolution 3D 7 Tesla Magnetic Resonance Spectroscopy Imaging (MRSI) in high-grade gliomas, we previously identified intratumoral metabolic heterogeneities.
In this study, we evaluated the potential of 3D 7 T-MRSI for the preoperative noninvasive classification of glioma grade and isocitrate dehydrogenase (IDH) status. We demonstrated that IDH mutation and glioma grade are detectable by ultra-high field (UHF) MRI. This technique might potentially optimize the perioperative management of glioma patients.

Methods
We prospectively included 36 patients with WHO 2021 grade 2–4 gliomas (20 IDH mutated, 16 IDH wildtype). Our 7 T 3D MRSI sequence provided high-resolution metabolic maps (e.g., choline, creatine, glutamine, and glycine) of these patients’ brains. We employed multivariate random forest and support vector machine models to voxels within a tumor segmentation, for classification of glioma grade and IDH mutation status.

Results
Random forest analysis yielded an area under the curve (AUC) of 0.86 for multivariate IDH classification based on metabolic ratios. We distinguished high- and low-grade tumors by total choline (tCho) / total N-acetyl-aspartate (tNAA) ratio difference, yielding an AUC of 0.99. Tumor categorization based on other measured metabolic ratios provided comparable accuracy.

Conclusions
We successfully classified IDH mutation status and high- versus low-grade gliomas preoperatively based on 7 T MRSI and clinical tumor segmentation. With this approach, we demonstrated imaging based tumor marker predictions at least as accurate as comparable studies, highlighting the potential application of MRSI for pre-operative tumor classifications.
The hepatoprotective effect of 4-phenyltetrahydroquinolines on carbon tetrachloride induced hepatotoxicity in rats through autophagy inhibition
Authors: Abdelgalil Mohamed Hussein , Elhammamy Reem H. , Ragab Hanan M. , Sheta Eman , Wahid Ahmed 
Published: May 2024

Abstract
Background
The liver serves as a metabolic hub within the human body, playing a crucial role in various essential functions, such as detoxification, nutrient metabolism, and hormone regulation. Therefore, protecting the liver against endogenous and exogenous insults has become a primary focus in medical research. Consequently, the potential hepatoprotective properties of multiple 4-phenyltetrahydroquinolines inspired us to thoroughly study the influence of four specially designed and synthesized derivatives on carbon tetrachloride (CCl4)-induced liver injury in rats.

Methods and results
Seventy-seven Wistar albino male rats weighing 140 ± 18 g were divided into eleven groups to investigate both the toxicity profile and the hepatoprotective potential of 4-phenyltetrahydroquinolines. An in-vivo hepatotoxicity model was conducted using CCl4 (1 ml/kg body weight, a 1:1 v/v mixture with corn oil, i.p.) every 72 h for 14 days. The concurrent treatment of rats with our newly synthesized compounds (each at a dose of 25 mg/kg body weight, suspended in 0.5% CMC, p.o.) every 24 h effectively lowered transaminases, preserved liver tissue integrity, and mitigated oxidative stress and inflammation. Moreover, the histopathological examination of liver tissues revealed a significant reduction in liver fibrosis, which was further supported by the immunohistochemical analysis of α-SMA. Additionally, the expression of the apoptotic genes BAX and BCL2 was monitored using real-time PCR, which showed a significant decrease in liver apoptosis. Further investigations unveiled the ability of the compounds to significantly decrease the expression of autophagy-related proteins, Beclin-1 and LC3B, consequently inhibiting autophagy. Finally, our computer-assisted simulation dockingonfirmed the obtained experimental activities.

Conclusion
Our findings suggest that derivatives of 4-phenyltetrahydroquinoline demonstrate hepatoprotective properties in CCl4-induced liver damage and fibrosis in rats. The potential mechanism of action may be due to the inhibition of autophagy in liver cells.
Factors affecting major depression in Iran: a mixed-method study
Authors: Hosseinzadeh-Shanjani Zarrintaj , Khodayari-Zarnaq Rahim , Khosravi Mohammad Farough , Arab-Zozani Morteza , Alizadeh Gisoo 
Published: May 2024

AbstractDepression is a major cause of disability and, if left untreated, can increase the risk of suicide. Evidence on the determinants of depression is incomplete, making it challenging to interpret results across studies. This study aims to identify the social, economic, environmental, political, and technological factors influencing the great recession in Iran. The study was conducted in two parts. The first step involved a literature review to identify the factors, using PubMed, Scopus, and Web of Science for the search. The reference lists of all identified articles were reviewed to find relevant studies, and the extracted information was summarized and reported descriptively. The second steps involved compiling and consulting 14 experts from different fields, using a framework analysis method. Twenty-four articles were used as primary sources of information, and a total of 28 factors were found to exist. After removing duplicates and related factors, 19 of these were subsequently declared as factors, resulting in a total of 36 determinants being identified. Most of these factors belong to the social category. The health policies implemented have a significant impact on disease risk factors and ultimately their occurrence. Political decisions and policy-making processes play a crucial role in all areas, particularly in addressing disease risk factors. Severe depression can disrupt all aspects of the healthcare system, underscoring the importance of access to care. Policies concerning physical education, transportation, nutrition, employment, green spaces, recreational facilities, and tobacco are vital in this context. The influence of health policies on disease risk factors and disease occurrence is profound. Severe depression can have far-reaching effects on the healthcare system, emphasizing the critical need for access to care. The formulation of policies to combat depression must be thoroughly evaluated in terms of economic, political, social, technological, and environmental factors. The findings suggest that addressing social inequalities and emphasizing the role of political action, as highlighted by the social determinants of health, should be top priorities in addressing depression. Efforts to prevent depression should incorporate ecological approaches that consider the impact of the socioeconomic environment on depressive symptoms.
The effects of probiotic supplementation on cerebral cognitive function: a systematic review
Authors: Widyadharma I Putu Eka , Hendellyn Alvin , de Liyis Bryan Gervais , Putri Ni Luh Putu Saswatasya Widha , Indrayani Agung Wiwiek , Darwinata Agus Eka , Sujaya I Nengah 
Published: May 2024

Abstract
Background
Alzheimer’s disease (AD) stands as a formidable challenge within the realm of neurodegenerative disorders, characterized by its inexorable progression and the profound cognitive impairments it engenders. Despite decades of research, the management of AD remains in a conundrum, with currently available treatments offering only modest symptomatic relief and none that can definitively alter the course of the disease.

Objective
This investigation seeks to provide a concise overview of the influence of probiotics on the cognitive aspects of AD, drawing upon a compilation of conducted studies.

Methods
The study was conducted by means of comprehensive searches in MEDLINE, Pubmed, and Google Scholar databases spanning from January 2015 to December 2020. The composition of this review adhered to the guidelines outlined by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The evaluation of eligibility criteria was guided by the Population, Intervention, Comparator, Outcome, and Study Design (PICOS) framework, a methodology that was systematically applied to each identified research entry.

Results
Upon the implementation of the search protocol, a total of five articles that satisfied the predetermined inclusion criteria were incorporated into this review. Among these, four encompassed randomized controlled trials (RCTs), while the fifth pertained to an explorative interventional study. AD stands as a progressive neurodegenerative affliction of considerable clinical import. Through the assessment of diverse investigations, compelling evidence has emerged affirming that probiotic microorganisms, acting via the intricate gut–brain axis signaling pathway, harbor the capacity to ameliorate cognitive function in AD. The collective findings across all the studies unequivocally indicate a notable enhancement in cognitive function subsequent to the administration of probiotic supplementation (p < 0.05). While not all domains of cognitive function exhibit amelioration in response to probiotic supplementation, the consideration of incorporating probiotics within the therapeutic schema for AD warrants deliberation as a strategy to enhance cognitive performance.

Conclusion
Despite the intricate pathophysiology of AD, probiotic supplementation exerts a discernible influence on cognitive well-being. Notably, the symbiotic interplay between the gut and the brain, elucidated through the intricate gut–brain axis, emerges as a conduit through which probiotics could potentially modulate cognitive function.
Neuro-sarcoidosis with isolated optic neuropathy: unmasking the chameleon
Authors: Jha Shreyashi , Pendyala Santosh Kumar , Tiwari Mona 
Published: May 2024

AbstractIsolated optic nerve involvement is rare in sarcoidosis. We report three cases describing atypical clinical and radiological features of isolated optic nerve involvement in sarcoidosis to expand the spectrum of neuro-ophthalmic sarcoidosis. Bilateral optic neuritis, sudden vision loss, primary optic atrophy, long segment optic neuritis, and isolated intrao-orbital sarcoidosis are described as atypical features of optic nerve involvement in this case series.
Comparative study between different types of intermediate osteotomies in twisted nose deformity management: a randomized controlled trial
Authors: Sabaa Mohamed A. E. , Elfouly Mahmoud S. , Elemam Amr M. 
Published: May 2024

Abstract
Background
The nasal dorsum plays an important role in defining the facial harmony. Osteotomy techniques in rhinoplasty surgery are challenging, as in many cases they require visionless tissue manipulation to achieve an aesthetic facial symmetry. This research elucidates the aesthetic outcome of the different types of intermediate osteotomies for correction of twisted nose deformity.

Patients and methods
This study was randomized controlled trial on 20 selected patients, divided randomly into 2 groups: group A included 10 patients who underwent routine vertical intermediate nasal osteotomies, while group B involved 10 patients subjected to transverse intermediate nasal osteotomies. Patients were assessed aesthetically both by the surgeon and a layperson based on pre and postoperative VAS scale and frontal view photography.

Results
Comparing pre and postoperative VAS showed statistically significant improvement with median score improvement from 8 pre to 1–2 post which is 80% improvement with P value of 0.004 for surgeon and 0.004 for layperson. Comparing the postoperative VAS for both groups showed statistically insignificant difference with P value of 0.106 for surgeon and 0.218 for lay person.

Conclusion
Twisted nose deformity is one of the challenging cases in rhinoplasty. Both types of intermediate osteotomies have shown significant improvement in postoperative dorsal aesthetic view. There was no statistically significant difference between either group; yet, more improvement was noted in the transverse type.