bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of aging on male reproduction in zebrafish (Danio rerio)
Authors: Kanuga Manasi K. , Benner Maia J. , Doble Justin A. , Wilson‐Leedy Jonas G. , Robison Barrie D. , Ingermann Rolf L. 
Published: December 2010

AbstractThe study was designed to test the hypothesis that male aging is associated with a change in reproductive function in the zebrafish. Young (290 ± 37 d) and older (911 ± 48 d) males were combined with females (604 ± 24 d) to test the effect of male age on the number and fertility of eggs laid by their mates. 48% of breeding trials with young males and 25% of the trails with older males resulted in egg deposition. Although young males were associated with significantly more successful breeding attempts than older males, number of eggs laid per clutch, number and percent of fertilized eggs and the number and percent living embryos were not statistically different between young and older males. These data suggest that male aging is associated with altered reproductive behavior and/or female response but not in sperm quality per se. Consistent with this interpretation were the findings that percent motility and sperm motility characteristics did not differ between sperm from young and older males as assessed by computer‐assisted sperm analysis. However, older males contained higher quantities of extractable sperm than did young males, perhaps associated with fewer successful breeding attempts. Age‐related effects on male reproductive in the zebrafish may therefore be a consequence of behavioral or morphological features that play a role in female mate choice and/ or male sexual response. J. Exp. Zool. 315:156–161, 2011. © 2010 Wiley‐Liss, Inc.
Clinical utility of apparent diffusion coefficient (ADC) values in patients with prostate cancer: Can ADC values contribute to assess the aggressiveness of prostate cancer?
Authors: Itou Yasushi , Nakanishi Katsuyuki , Narumi Yoshifumi , Nishizawa Yasuko , Tsukuma Hideaki 
Published: December 2010

AbstractPurposeTo retrospectively evaluate the relationship between apparent diffusion coefficient (ADC) values and Gleason score (GS) in prostate cancer.MethodsA total of 60 patients who underwent radical prostatectomy for clinically localized prostate cancer were selected for this study. Diffusion‐weighted magnetic resonance (MR) images were obtained using a 1.5 T system. ADC values were analyzed between three groups: GS of 6 or less (n = 7); GS of 7 (n = 37); and GS of 8 or higher (n = 16). ADC values of the three GS groups were statistically analyzed in order to determine the relationship with GS. In the 37 patients with GS = 7 the difference in ADC values between GS 3+4 and GS 4+3 was analyzed.ResultsMedian ADC values (10−3 mm2/s) of the three GS groups were 1.04 (GS = 6 or less), 0.867 (GS = 7), and 0.729 (GS = 8 or higher). Although there was considerable overlap among the groups, the differences in ADC were statistically significant (P < 0.0001). There was a significant inverse correlation between GS and ADC values (z = −0.437, P < 0.0005). Median ADC values (10−3 mm2/s) of GS 3+4 and GS 4+3 patients were 0.88 and 0.814, respectively (P < 0.05).ConclusionADC values showed a negative correlation with GS. Pathologically, however, there was considerable intrasubject heterogeneity. J. Magn. Reson. Imaging 2011;33:167–172. © 2010 Wiley‐Liss, Inc.
3 Tesla MRI detects accelerated hippocampal volume reduction in postmenopausal women
Authors: Goto Masami , Abe Osamu , Miyati Tosiaki , Inano Sachiko , Hayashi Naoto , Aoki Shigeki , Mori Harushi , Kabasawa Hiroyuki , Ino Kenji , Yano Keiichi , Iida Kyouhito , Mima Kazuo , Ohtomo Kuni 
Published: December 2010

AbstractPurposeTo clarify age‐related structural changes specific to hippocampal volume by hierarchizing according to age, gender, and menopausal status. Many studies report the neuroprotective effects of estrogen and age‐related brain volume changes; however, there are no studies regarding age‐related change specific to hippocampal volume in terms of age, gender, and menopausal status.Materials and MethodsT1‐weighted MR images were obtained in 412 healthy adults divided into eight groups according to age and gender, to analyze brain volume change focusing on hippocampal volume.ResultsVoxel‐based morphometry (VBM) revealed significantly smaller gray matter volume in the hippocampus bilaterally in females aged in their fifties (51 of 59 females were at menopause) compared with females in their forties (3 of 46 females were at menopause). No significant difference was found, however, between female groups in their fifties versus sixties, or sixties versus seventies; or between male groups in their forties versus fifties, fifties versus sixties, or sixties versus seventies. In addition, VBM revealed significant hippocampal volume reduction bilaterally in all postmenopausal women compared with all premenopausal women.ConclusionThe results of the current study suggest that the menopause may be associated with hippocampal volume reduction. J. Magn. Reson. Imaging 2011;33:48–53. © 2010 Wiley‐Liss, Inc.
Renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion: Radiological findings mimicking papillary subtype
Authors: Kato Hiroki , Kanematsu Masayuki , Yokoi Shigeaki , Miwa Kousei , Horie Kengo , Deguchi Takashi , Hirose Yoshinobu 
Published: December 2010

AbstractThe authors describe the computed tomography (CT) and magnetic resonance imaging (MRI) findings of an 18‐year‐old man with renal cell carcinoma (RCC) associated with the Xp11.2 translocation/transcription factor E3 (TFE3) gene fusion (Xp11 translocation carcinoma). The lesion was hyperdense on unenhanced CT, hypovascular on contrast‐enhanced studies, hypointense on T2‐weighted MR images, and hemosiderin deposition was suspected on phase‐shift gradient‐echo MR images. Histopathological specimens revealed pathological findings resembling papillary RCC predominantly and exhibited immunoreactivity for TFE3. Because there is often considerable morphological overlap between this carcinoma and papillary RCC, the imaging findings of Xp11 translocation carcinoma may be similar to those of the papillary subtype. Therefore, Xp11 translocation carcinoma should be considered, particularly in young patients when radiologic images demonstrate a renal tumor mimicking the papillary subtype. J. Magn. Reson. Imaging 2011;33:217–220. © 2010 Wiley‐Liss, Inc.
Papillary muscle involvement in myocardial infarction: Initial results using multicontrast late‐enhancement MRI
Authors: Yang Yuesong , Connelly Kim , Graham John J. , Detsky Jay , Lee Tony , Walcarius Rhonda , Paul Gideon , Wright Graham A. , Dick Alexander J. 
Published: December 2010

AbstractWe hypothesized that multicontrast late‐enhancement (MCLE) MRI would improve the identification of papillary muscle involvement (PM‐MI) in patients with myocardial infarction (MI), compared with conventional late gadolinium enhancement (LGE) MRI using the inversion recovery fast gradient echo (IR‐FGRE) technique. Cardiac LGE‐MRI studies using both MCLE and IR‐FGRE pulse sequences were performed on a 1.5 Tesla (T) MRI system in 23 patients following MI. In all patients, PM‐MI was confirmed by the diagnostic criteria as outlined below: (a) the increased signal intensity of PM was the same or similar to that of adjacent hyper‐enhanced left ventricular (LV) infarct segments; and (b) the hyper‐enhanced PM region was limited to the PM area defined by precontrast cine images of steady‐state free precession (SSFP). Visual contrast score was rated according to the differentiation between LV blood pool and hyper‐enhanced infarct myocardium. Quantitative contrast‐noise ratios (CNR) of infarct relative to blood pool and viable myocardium were also measured on MCLE and IR‐FGRE images. Of these 23 patients, 13 studies demonstrated primarily involvement of the territories of the right coronary (RCA, 8 patients) and/or left circumflex (LCX, 5 patients) arteries and 10 involved the territories of left anterior descending artery (LAD) with some LCX involvement. Although both IR‐FGRE and MCLE determined the presence and extent of LV MI, better visual contrast scores were achieved in MCLE (2.9 ± 0.3) compared with IR‐FGRE (1.6 ± 0.8, P < 0.001). The CNRs of infarct relative to LV blood pool showed a significant statistical difference (n = 23, P < 0.00001) between MCLE (16.2 ± 7.2) and IR‐FGRE images (4.8 ± 4.1), which is consistent with the result of visual contrast scores between infarct and LV blood pool. The CNRs of infarct versus viable myocardium did not demonstrate a significant statistical difference (n = 23, P = 0.61) between MCLE (14.4 ± 7.0) and IR‐FGRE images (13.6 ± 6.1). MCLE clearly demonstrated PM‐MI in all cases (100%, 23/23) while only 39% (9/23) could be visualized on the corresponding IR‐FGRE images. In conclusion, MCLE imaging provides better contrast between blood pool and infarct myocardium, thus improving the determination of PM‐MI. J. Magn. Reson. Imaging 2011;33:211–216. © 2010 Wiley‐Liss, Inc.
Correlation of the apparent diffusion coefficient value and dynamic magnetic resonance imaging findings with prognostic factors in invasive ductal carcinoma
Authors: Jeh Su Kyung , Kim Sung Hun , Kim Hyeon Sook , Kang Bong Joo , Jeong Seung Hee , Yim Hyeon Woo , Song Byung Joo 
Published: December 2010

AbstractPurposeTo evaluate the correlation of the mean and minimal apparent diffusion coefficient values (ADCmean, ADCminimal) and dynamic magnetic resonance imaging (MRI) findings with prognostic factors in invasive ductal carcinoma.Materials and MethodsA total of 107 women with invasive ductal cancer underwent breast MRI. The ADCmean and ADCminimal of the cancers were computed. MRI findings were retrospectively evaluated according to the Breast Imaging Reporting and Data System (BI‐RADS) lexicon: mass or nonmass type, mass shape, mass margin, nonmass distribution, and enhancement pattern. Histological records were reviewed for tumor size, lymph node metastasis, histologic grade, and expression of estrogen receptors (ER), progesterone receptors (PR), c‐erbB‐2(HER2), Ki‐67, and epidermal growth factor receptors (EGFR). Correlations of ADC values and MR findings with prognostic factors were determined using the Mann–Whitney U‐test and the Kruskal–Wallis test.ResultsThe mean ADCminimal was 0.78 ± 0.24 (×10−3 mm2/s), and the mean ADCmean was 1.01 ± 0.23 (×10−3 mm2/s). There was a significant correlation of the ADCmean value with ER expression (P = 0.027) and HER2 expression (P = 0.018). There was no significant relationship between ADCminimal and prognostic factors or between ADCmean and traditional prognostic factors, PR, Ki‐67 and EGFR. The majority of the mass type lesions were less than 5 cm in size and the majority of nonmass type lesions were more than 2 cm in size (P = 0.022). The margin of mass was significantly associated with lymph node metastasis (P = 0.031), ER expression (P = 0.013), PR expression (P = 0.036), HER2 expression (P = 0.019), and EGRF expression (P = 0.041). The rim internal enhancement was significantly correlated with Ki‐67 expression (P = 0.008).ConclusionThe low ADCmean value was related to positive expression of ER and negative expression of HER2. A spiculated margin was related to a good prognosis, but rim enhancement was associated with a poor prognosis. J. Magn. Reson. Imaging 2011;33:102–109. © 2010 Wiley‐Liss, Inc.
T1‐weighted ultrashort echo time method for positive contrast imaging of magnetic nanoparticles and cancer cells bound with the targeted nanoparticles
Authors: Zhang Longjiang , Zhong Xiaodong , Wang Liya , Chen Hongwei , Wang Y. Andrew , Yeh Julie , Yang Lily , Mao Hui 
Published: December 2010

AbstractPurposeTo obtain positive contrast based on T1 weighting from magnetic iron oxide nanoparticle (IONP) using ultrashort echo time (UTE) imaging and investigate quantitative relationship between positive contrast and the core size and concentration of IONPs.Materials and MethodsSolutions of IONPs with different core sizes and concentrations were prepared. T1 and T2 relaxation times of IONPs were measured using the inversion recovery turbo spin echo (TSE) and multi‐echo spin echo sequences at 3 Tesla. T1‐weighted UTE gradient echo and T2‐weighted TSE sequences were used to image IONP samples. U87MG glioblastoma cells bound with arginine‐glycine‐aspartic acid (RGD) peptide and IONP conjugates were scanned using UTE, T1 and T2‐weighted sequences.ResultsPositive contrast was obtained by UTE imaging from IONPs with different core sizes and concentrations. The relative‐contrast‐to‐water ratio of UTE images was three to four times higher than those of T2‐weighted TSE images. The signal intensity increases as the function of the core size and concentration. Positive contrast was also evident in cell samples bound with RGD‐IONPs.ConclusionUTE imaging allows for imaging of IONPs and IONP bound tumor cells with positive contrast and provides contrast enhancement and potential quantification of IONPs in molecular imaging applications. J. Magn. Reson. Imaging 2011;33:194–202. © 2010 Wiley‐Liss, Inc.
Diffusion‐weighted magnetic resonance imaging of pancreatic adenocarcinomas: Association with histopathology and tumor grade
Authors: Wang Yi , Chen Zongming E. , Nikolaidis Paul , McCarthy Robert J. , Merrick Laura , Sternick Laura A. , Horowitz Jeanne M. , Yaghmai Vahid , Miller Frank H. 
Published: December 2010

AbstractPurposeTo evaluate the utility of diffusion‐weighted magnetic resonance imaging (DWI) in pancreatic ductal adenocarcinoma with various grades of differentiation.Materials and MethodsFollowing Institutional Review Board (IRB) approval, 21 consecutive patients with surgical pathology‐proven pancreatic adenocarcinomas were retrospectively evaluated. Histopathologic characteristics and grades of differentiation of adenocarcinomas were analyzed. Twenty‐one patients without a known history of pancreatic disease were evaluated as the control group. Anatomic MR images and DW images were acquired using 1.5‐T MR systems. DWI with b values of 0 and 500 sec/mm2 were performed on both patients and control groups. The difference in mean apparent diffusion coefficient (ADC) values among groups of normal pancreatic parenchyma, adenocarcinomas with poor differentiation, and adenocarcinomas with well/moderate differentiation were compared using one‐way analysis of variance.ResultsMean ADCs of pancreatic adenocarcinomas (1.77 ± 0.45 × 10−3mm2/sec) was not significantly lower than that of normal parenchyma (1.98 ± 0.31) (P = 0.09). When adenocarcinomas were subdivided based on grades of differentiation, however, poorly differentiated adenocarcinoma with histopathologic characteristics of limited glandular formation and dense fibrosis had significantly lower ADCs (1.46 ± 0.17) compared to those of well/moderately differentiated adenocarcinomas (2.10 ± 0.42) characterized by neoplastic tubular structures (P < 0.01). Well/moderately differentiated adenocarcinomas with dense fibrosis showed significantly lower ADC values (1.49 ± 0.19) than those with loose fibrosis (2.26 ± 0.30) (P = 0.01).ConclusionDifference in ADC values using DWI between poorly and well/moderately differentiated pancreatic ductal adenocarcinoma may relate to differences in glandular formation and density of fibrosis. J. Magn. Reson. Imaging 2011;33:136–142. © 2010 Wiley‐Liss, Inc.
Time‐resolved magnetic resonance angiography: Evaluation of intrapulmonary circulation parameters in pulmonary arterial hypertension
Authors: Jeong Hyun J. , Vakil Parmede , Sheehan John J. , Shah Sanjiv J. , Cuttica Michael , Carr James C. , Carroll Timothy J. , Davarpanah Amir 
Published: December 2010

AbstractPurposeTo determine whether pulmonary arterial and venous transit times measured by time‐resolved magnetic resonance angiography (MRA) can be used as a diagnostic tool for pulmonary arterial hypertension (PAH).Materials and MethodsTwelve patients with confirmed PAH and 10 healthy volunteers were scanned with Institutional Review Board (IRB) approval. Time‐resolved MRA and 2D phase contrast flow images of the pulmonary vasculature were acquired. Pulmonary arterial and venous transit times (PaTT and PvTT) and pulmonary valve flow (PVF) were obtained. Pulmonary arterial and pulmonary venous blood volumes (PaBV and PvBV) were calculated as the product of flow and transit time.ResultsPatients with PAH showed statistically significant increases in PaTT and PvTT (P < 0.0004, P < 0.05, respectively) compared to controls. PaBV (165.2 ± 92.0 mL) was significantly higher in PAH subjects than controls (97.0 ± 47.1 mL) (P < 0.04), whereas PvBV (127.9 ± 148.9 mL) of PAH subjects had no significant increase from those of healthy controls (142.5 ± 104.1 mL) (P < 0.38).ConclusionPulmonary arterial transit times measured using time‐resolved MRA can be used as a simple, noninvasive metric for detection of altered hemodynamics in PAH. J. Magn. Reson. Imaging 2011;33:225–231. © 2010 Wiley‐Liss, Inc.
Gadoxetic acid disodium‐enhanced magnetic resonance imaging for biliary and vascular evaluations in preoperative living liver donors: Comparison with gadobenate dimeglumine‐enhanced MRI
Authors: Lee Myoung Seok , Lee Jae Young , Kim Seung Ho , Park Hee Sun , Kim Se Hyung , Lee Jeong Min , Han Joon Koo , Choi Byung Ihn 
Published: December 2010

AbstractPurposeTo compare gadoxetic acid disodium (Gd‐EOB‐DTPA)‐enhanced magnetic resonance imaging (MRI) with gadobenate dimeglumine (Gd‐BOPTA)‐enhanced MRI in preoperative living liver donors for the evaluation of vascular and biliary variations.Materials and MethodsSixty‐two living liver donors who underwent preoperative MRI were included in this study. Thirty‐one patients underwent MRI with Gd‐EOB‐DTPA enhancement, and the other 31 underwent MRI with Gd‐BOPTA enhancement. Two abdominal radiologists retrospectively reviewed dynamic T1‐weighted and T1‐weighted MR cholangiography images and ranked overall image qualities for the depiction of the hepatic artery, portal vein, hepatic vein, and bile duct on a 5‐point scale and determined the presence and types of normal variations in each dynamic phase. Semiquantitative analysis for bile duct visualization was also conducted by calculating bile duct‐to‐liver contrast ratios.ResultsNo statistical differences were found between the two contrast media in terms of hepatic artery or bile duct image quality by the two reviewers, or in terms of portal vein image quality by one reviewer (P > 0.05). Gd‐BOPTA provided better image qualities than Gd‐EOB‐DTPA for the depiction of hepatic veins by both reviewers, and for the depiction of portal veins by one reviewer (P < 0.01). The two contrast media‐enhanced images had similar bile duct‐to‐liver contrast ratios (P > 0.05). Regarding diagnostic accuracies with hepatic vascular/biliary branching types, no significant differences were observed between the two contrast media (P > 0.05).ConclusionGd‐EOB‐DTPA could be as useful as Gd‐BOPTA for the preoperative evaluation of living liver donors, and has the advantage of early hepatobiliary phase image acquisition. J. Magn. Reson. Imaging 2011;33:149–159. © 2010 Wiley‐Liss, Inc.
Three‐dimensional contrast‐enhanced hepatic MR imaging: Comparison between a centric technique and a linear approach with partial Fourier along both slice and phase directions
Authors: Kim Kyung Ah , Herigault Gwenael , Kim Myeong‐Jin , Chung Young Eun , Hong Hye‐Suk , Choi Sun Young 
Published: December 2010

AbstractPurposeTo compare the image quality of two variants of a three‐dimensional (3D) gradient echo sequence (GRE) for hepatic MRI.Materials and MethodsThirty‐nine patients underwent hepatic MRI on a 3.0 Tesla (T) magnet (Intera Achieva; Philips Medical Systems). The clinical protocol included two variants of a 3D GRE with fat suppression: (i) a “centric” approach, with elliptical centric k‐space ordering and (ii) an “enhanced” approach using linear sampling and partial Fourier in both the slice and phase encoding direction. “Centric” and “Enhanced” 3D GRE images were obtained both precontrast (n = 32) and after gadoxetic acid injection (n = 39). Two reviewers jointly reviewed MR images for anatomic sharpness, overall contrast, homogeneity, and absence of artifacts. The liver‐to‐lesion signal difference ratio (SDR) was measured. Paired sample Wilcoxon test and paired t‐tests were used.ResultsEnhanced 3D GRE images performed better than centric 3D GRE images with respect to anatomic sharpness (P = 0.0156), overall contrast (P = 0.0195), homogeneity (P < 0.0001), and absence of artifacts (P = 0.0003) on precontrast images. For postcontrast MRI, enhanced 3D GRE images showed better quality in terms of overall contrast (P = 0.0195), homogeneity (P < 0.0001), and absence of artifacts (P = 0.009). Liver‐to‐lesion SDR on enhanced 3D GRE images (0.48 ± 0.13) was significantly higher than that of conventional 3D GRE images (0.40 ± 0.19, P = 0.0004) on postcontrast images, but not on precontrast images.ConclusionThe enhanced 3D GRE sequence available on our scanner provided better hepatic image quality than the centric variant, without compromising lesion contrast. J. Magn. Reson. Imaging 2011;33:160–166. © 2010 Wiley‐Liss, Inc.
A study of characteristic fragmentation of isoflavonoids by using negative ion ESI‐MSn
Authors: Ablajan Keyume 
Published: December 2010

AbstractIsoflavone mono‐O‐glycosides were investigated by electrospray ionization tandem mass spectrometry with a quadrupole linear ion trap mass spectrometer in negative ion mode. Isoflavonoids having different positions of glycosylation or methylation were differentiated according to the relative abundances of Y0− and [Y0− H]−• ions generated from the [M − H]− ion. It is found that the site of glycosyl or methyl group significantly affects relative abundances of the Y0− and [Y0− H]−• ions. In addition, the characteristic ion [Y0− 2H]− was observed in the product ion spectrum of genistein 7‐O‐β‐D‐glucoside and was also detected, together with the [Y0− CH3]−• and [Y0− H − CH3]− ions in the product ion spectra of glycitin and 6‐methoxy genistein 7‐O‐β‐D‐glucoside. The structures of isoflavonoids can be characterized and identified according to the formation of these diagnostic ions. The results obtained from this investigation can promote the rapid identification of isoflavonoids in crude plant extracts. Copyright © 2010 John Wiley & Sons, Ltd.
Adaptive patterns of movement during arm elevation test in patients with shoulder impingement syndrome
Authors: Lin Jiu‐jenq , Hsieh Shih‐Chang , Cheng Wei‐Cheng , Chen Wei Chun , Lai Yuta 
Published: December 2010

AbstractThe purpose of this study was to determine if a distinctive characteristic exists in the pattern of movement (scapular elevation and upward rotation to reduce impingement) and associated muscular activities during arm elevation in subjects with shoulder impingement (SI) that is associated with the severity of the disease. Fourteen subjects (7 amateur athletes and 7 student athletes) with SI and 7 controls performed arm elevation in the scapular plane. Scapular kinematics (upward rotation, elevation, tipping, and scapulohumeral rhythm) and muscular activity [upper trapezius (UT), lower trapezius (LT), serratus anterior (SA), and deltoid] were measured by an electromagnetic motion tracking system and surface electromyography, respectively. Subjects with SI had greater elevation of the scapula (11.9 mm, p < 0.005) and less peak scapular posterior tipping (10.6°, p < 0.02) than controls. In more severe subjects (amateur athletes), the elevation and posterior tipping of the scapula were correlated with an increase in the UT (R = −0.818, p = 0.025) and a decrease in SA (R = 0.772, p = 0.040) activity, respectively. Our results identified a characteristic compensatory scapular elevation to reduce impingement during arm elevation in subjects with SI. Assessing scapular elevation during arm elevation may be a useful functional marker for evaluating impingement status and associated muscle function. Additionally, SA and LT muscle strengthening may improve SI. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 29:653–657, 2011