bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating Interleukin 17A and Other Inflammatory Proteins May Predict Cardiovascular Disease in Early Rheumatoid Arthritis
Authors: Rydell Emil , Jacobsson Lennart T.H. , Turesson Carl 
Published: May 2024

ObjectiveThe objective of this study was to investigate the impact of 92 inflammatory proteins on the risk of cardiovascular disease (CVD) in patients with early rheumatoid arthritis (RA).MethodsThis study included consecutive patients with early RA recruited between 1995 and 2002. Stored plasma samples were analyzed for 92 inflammatory proteins. CVD diagnoses were retrieved from national in-patient and cause-of-death registries. Statistical analyses were predesignated as hypothesis-driven or exploratory. For the latter, proteins were selected based on principal component analysis (ie, factor loading > 0.5 within main components). Potential predictors of CVD and coronary artery disease (CAD) were assessed using Cox regression.ResultsData on baseline levels of proteins and CVD were available for 163 patients. As hypothesized, levels of interleukin 17A (IL-17A) were associated with CVD (hazard ratio 1.35, 95% CI 1.02-1.78, adjusted for age, sex, hypertension, diabetes, smoking, and erythrocyte sedimentation rate [ESR]), although not significantly with CAD. Osteoprotegerin (OPG) levels were significantly associated with both outcomes, but only in crude models. No associations were observed for IL-6, tumor necrosis factor, monocyte chemotactic protein-1, or IL-8. In the exploratory analyses, MCP-3 in particular had significant associations with both outcomes in crude models.ConclusionCirculating IL-17A at RA diagnosis predicted future CVD, although we cannot exclude the possibility that this finding is due to multiple testing. The association was independent of traditional CVD risk factors, and of ESR at the time of diagnosis. Further, OPG may be a predictor of CVD. We also identified some novel potential biomarkers for CVD in RA.
Preliminary Analysis of Fall Concern Among Family Caregivers of Older Adults Discharged From the Hospital: A Psychometric Evaluation of the Carers' Fall Concern Instrument
Authors: Ang Seng Giap Marcus , Saunders Rosemary , Siah Chiew Jiat Rosalind , Wee Yan Hui Celestine , Etherton-Beer Christopher , Foskett Charlotte , Gullick Karen , Haydon Sue , Wilson Amanda 
Published: May 2024

Purpose:
To provide a preliminary descriptive analysis of the change in fall concern among family caregiver–care recipient dyads during hospitalization and after discharge as part of a prospective study exploring the psychometric properties of the Carers' Fall Concern Instrument.

Method:
Using a prospective cohort design, an interviewer-administered survey was completed by dyads at 48 hours before discharge and 1 week and 30 days after discharge.

Results:
Of family caregivers, 76.9% thought their care recipient was at risk of falling and 61.5% were afraid of them falling. However, only 34.6% of older adults thought that they were at risk of falling and only 42.3% were afraid of falling. Family caregivers reported significantly less concern about falls after their care recipients were discharged.

Conclusion:

This study provided greater insight into caregiver–care recipient dyads' fall concern during their transition from hospital to home that may guide post-discharge fall prevention education on falls. [
Journal of Gerontological Nursing, 50
(5), 14–18.]
Effectiveness of Resistance Band Use in Conjunction With Tai Chi Among Older Adults With Prefrailty to Improve Functional Fitness, Quality of Life, and Heart Rate Variability
Authors: Woo Shan-Che , Chen Miao-Yen , Chen Liang-Kung , Liu Chieh-Yu 
Published: May 2024

Purpose:
The current randomized controlled trial aimed to bolster the physical fitness of prefrail older adults, potentially delaying their need for admission to care facilities and enhancing their overall well-being.

Method:
The experimental group received a physical fitness intervention comprising resistance band use and tai chi three times per week for 12 weeks, whereas the control group received frailty-related health education. Thirty-four male participants completed the study.

Results:

A total of seven items had statistically significant differences at 12- and 16-week posttest, respectively: frailty index (
p
= 0.03;
p
= 0.03); Instrumental Activities of Daily Living Scale (
p
< 0.001;
p
< 0.001); and physical fitness, back (
p
< 0.001;
p
< 0.001); physical fitness, arm curl (
p
= 0.02;
p
< 0.001); physical activity (
p
< 0.001;
p
= 0.009); quality of life, physiological (
p
= 0.04;
p
< 0.001); and heart rate variability (
p
< 0.001;
p
< 0.001).

Conclusion:

Results revealed substantial improvements in physical fitness, frailty conditions, self-care abilities, and quality of life, but not balance or lower limb flexibility, for the experimental group. Therefore, exercise interventions may effectively improve prefrail older adults' quality of life. [
Journal of Gerontological Nursing, 50
(5), 19–26.]
Psychometric Evaluation of the Family Willingness for Caregiving Scale
Authors: Wilk Cindy , Petrinec Amy 
Published: May 2024

Background
Family members and close friends of patients undergoing mechanical ventilation in the intensive care unit (ICU) often experience stress and a sense of helplessness. Participating in the care of their loved one may improve their adaptation to the ICU environment and better prepare them for caregiving after discharge.

Objectives
The primary aim of this study was to develop the Family Willingness for Caregiving Scale (FWCS) and test its psychometric properties. The secondary aim was to examine relationships between family members’ demographic characteristics and caregiving willingness.

Methods
The process of scale development followed DeVellis’s 8-step method, and the scale was tested in 3 phases. The first 2 phases examined content validity and face validity, respectively. In phase 3, the FWCS was administered to a sample of family members currently visiting an ICU patient.

Results
Content validity and face validity were confirmed. The internal consistency reliability of the scale was acceptable, and exploratory factor analysis revealed a 1-factor structure comprising both physical and emotional/supportive care tasks. Caregiving willingness differed significantly by sex, with women reporting greater willingness than men reported.

Conclusions
Further testing of the FWCS is needed. After refinement, the FWCS could be used to evaluate factors contributing to caregiving willingness of family members of ICU patients and advance the science related to family engagement in the ICU. Additionally, it could be used as a practical tool to suggest family caregiving activities in the ICU.
PRRT with Lu-177 DOTATATE in Treatment-Refractory Progressive Meningioma: Initial Experience from a Tertiary-Care Neuro-Oncology Center
Authors: Puranik Ameya D , Dev Indraja D , Rangarajan Venkatesh , Kulkarni Suyash , Shetty Nitin , Gala Kunal , Sahu Arpita , Bhattacharya Kajari , Dasgupta Archya , Chatterjee Abhishek , Gupta Tejpal , Sridhar Epari , Sahay Ayushi , Shetty Prakash , Singh Vikas , Moiyadi Aliasgar , Menon Nandini , Purandare Nilendu C , Agrawal Archi , Shah Sneha , Choudhury Sayak , Ghosh Suchismita , Jha Ashish Kumar 
Published: May 2024

Purpose:
Refractory and/or recurrent meningiomas have poor outcomes, and the treatment options are limited. Peptide receptor radionuclide therapy (PRRT) has been used in this setting with promising results. We have documented our experience of using intravenous (IV) and intra-arterial (IA) approaches of Lu-177 DOTATATE PRRT.

Methods:
Eight patients with relapsed/refractory high-grade meningioma received PRRT with Lu-177 DOTATATE by IV and an IA route. At least 2 cycles were administered. Time to progression was calculated from the first PRRT session to progression. The response was assessed on MRI using RANO criteria, and visual analysis of uptake was done on Ga-68 DOTANOC PET/CT. Post-therapy dosimetry calculations for estimating the absorbed dose were performed.

Results:
Median time to progression was 8.9 months. One patient showed disease progression, whereas seven patients showed stable disease at 4 weeks following 2 cycles of PRRT. Dosimetric analysis showed higher dose and retention time by IA approach. No significant peri-procedural or PRRT associated toxicity was seen.

Conclusion:
PRRT is a safe and effective therapeutic option for relapsed/refractory meningioma. The IA approach yields better dose delivery and should be routinely practised.
Serum Apo Lipoprotein E, Apo Lipoprotein E Gene Polymorphisms, and Parkinson’s Disease
Authors: Fahmy Ebtesam M. , Rabah Amany M. , Hashem Saher E. , Rashed Laila A. , Deraz Heba A. , Ismail Rania S. 
Published: May 2024

Background:
A central role for apolipoprotein E (APOE) has been suggested in modulating processes of neurodegeneration.

Objective:
To study the association between serum APOE levels, APOE gene polymorphisms, and Parkinson’s disease (PD).

Material and Methods:
Fifty-five patients with PD and 30 healthy subjects were enrolled. PD patients were assessed using the Unified Parkinson’s Disease Rating Scale (UPDRS), Modified Hoehn and Yahr scale, and Schwab-England Activities of Daily Living scale. Serum APOE level and genotyping for APOE polymorphisms were done for PD patients and controls using enzyme-linked immunosorbent assay and polymerase chain reaction, respectively.

Results:
Mean serum APOE level was significantly higher in PD patients compared with healthy controls. APOE ε2/4 genotype was present in a significantly higher proportion of patients compared with controls. APOE ε4 allele was significantly associated with a higher score on the “mentation, behavior, and mood section” of UPDRS compared with ε2 allele. APOE ε2 allele was significantly associated with a shorter disease duration compared with ε3 and ε4 alleles. Mean serum APOE level was significantly higher in patients presenting predominantly by rigidity and bradykinesia compared with those presenting predominantly by tremors. Serum APOE level was positively correlated with mean scores of “mentation, behavior, and mood section” of UPDRS and disease duration. Serum APOE level was a significant predictor for the scores of “mentation, behavior, and mood section” of UPDRS.

Conclusion:
APOE ε2/4 genotype might be a susceptibility variant for PD. There may be a possible role for APOE in modulating the process of neurodegeneration in PD.
Evaluation of interleukin-6 in gingival crevicular fluid in patients with periodontitis
Authors: Gani Mudasir , Abbas Rezhat , Rashid Munaza 
Published: May 2024

Introduction:
Periodontal diseases are disease processes involving the periodontium, a term that describes the supportive apparatus surrounding a tooth. Periodontitis is when the periodontal condition has progressed beyond gingivitis into a chronic, destructive, and irreversible inflammatory disease state. The bacteria can then penetrate deeper into the tissues and surrounding periodontium, triggering a host response in an attempt to defend against the invading bacteria. Many inflammatory cytokines regulate periodontitis pathophysiology through a cross-talk between tissue and immune cells. Interleukin (IL)-6 is a vital cytokine regulating host response to bacterial infection.

Aim:
The current study aimed to quantify IL-6 levels in gingival crevicular fluid (GCF) and assess the correlation with periodontitis.

Materials and Methods:
There were 22 study subjects: 11 study subjects (with periodontitis) and 11 control subjects (with healthy periodontium). The commercial human IL-6 ELISA kit (Elabscience) was used to measure the level of IL-6 as ng IL-6/ml of GCF.

Results and Discussion:
The control group had a mean ± standard deviation level of IL-6 of 0.56 ± 0.29, whereas the study group had 1.58 ± 0.23. The difference was statistically significant (P < 0.05).

Conclusion:
IL-6 assessment in GCF has an excellent prognostic role in periodontitis.
Development of natural polymers-based inhaled microspheres for tuberculosis
Authors: Rani Yotomi Desia Eka , Rahmadi Mahardian , Hariyadi Dewi Melani 
Published: May 2024

Background: Tuberculosis (TB) is a contagious disease caused by Mycobacterium tuberculosis (Mtb) that mainly affects the lungs (pulmonary TB). Treatment involves a 6-month regimen of four first-line anti-TB drugs: isoniazid (INH), rifampicin (RIF), ethambutol (ETH), and pyrazinamide (PZA). However, the effectiveness of this regimen is limited due to the protection of Mtb bacteria in lung lesions. An alternative approach involves delivering the drugs directly to the lungs through inhalation using innovative methods of microspheres, which can greatly enhance treatment efficacy.
Objective: This review focuses on inhaled microspheres that use natural polymers for anti-tubercular drugs.
Method: A comprehensive literature survey was pulled from databases (PubMed, Scopus, Google Scholar, and ScienceDirect) from 2012 to 2022.
Result: The characterisation studies, formulation technique, and efficacy using in vitro and in vivo studies of anti-tuberculosis drugs inhaled microspheres.
Conclusion: Microspheres have substantial potential as an inhaled drug delivery system and are likely to have significant clinical contributions in the future.
Formulation, physicochemical characterisation, and in vitro evaluation of quercetin-alginate microsphere system
Authors: Hariyadi Dewi Melani , Azaria Shafa , Cindravani Lintang Arum , Ramadhani Annisa Dayu Syifa , Rani Yotomi Desia Eka , Sumartha I Nengah Budi , Nurhan Ahmad Dzulfikri , Aryani Toetik , Rahmadi Mahardian , Pathak Yashwant V , Ardianto Chrismawan 
Published: May 2024

Background: Quercetin exhibits various pharmacological properties. Unfortunately, quercetin has problems related to solubility, stability, and bioavailability, so it is necessary to develop an appropriate drug delivery system for quercetin.
Objective: The study aims to develop a quercetin microsphere system and determine the effect of sodium alginate concentration on the physical characteristics and release of quercetin from the microspheres.
Method: Quercetin-alginate microspheres were formed using sodium alginate with concentrations: Formula 1 (F1) 1%; Formula 2 (F2) 1.5%; Formula 3 (F3) 2% combined with 0.5 M CaCl2 using the ionotropic gelation and aerosolisation technique.
Results: The study found that the higher alginate concentration significantly increased microsphere particle size (6.53 – 8.34 µm) and decreased drug loading (11.58% - 6.08%). In addition, too low or high alginate concentrations accelerated the quercetin release. Variations of alginate concentration did not significantly affect the encapsulation efficiency, polydispersity index, and moisture content properties. The kinetic release of the microsphere followed the Higuchi kinetics model with the diffusion-controlled mechanism.
Conclusion: This study successfully developed an alginate microsphere system controlling quercetin release. In addition, variations in sodium alginate concentration affect the particle size, drug loading, and cumulative release of quercetin from the alginate microsphere system.
Sinergitas dan Peningkatan Kinerja Financial pada PT Logistik Raya
Authors: Simbolon Hotnita , Khomsiyah Khomsiyah 
Published: May 2024

Persaingan bisnis memiliki karakteristik yang kompetitif, oleh karena itu perlu untuk mengoptimalkan kinerja, baik itu struktur kerja, hingga ke metode kerja. Perusahaan selalu dituntut untuk memiliki kinerja yang baik dan maksimal. PT Logistik Raya merupakan perusahaan jasa angkutan yang termasuk besar di Tanjung Priok dan memiliki jumlah armada truck dengan kapasitas muatan hingga enam puluh ton. Untuk kinerja yang dihasilkan PT Logistik Raya perlu melakukan evaluasi strategi yang digunakan untuk peningkatan kinerja keuangan. Tujuan penelitian ini adalah untuk menjelaskan kinerja finansial PT Logistik Raya sebelum dan sesudah diterapkan program sinergitas antar group afiliasi Perusahaan, dan juga menganalisa SWOT dan Value Chain di PT. Logistik Raya untuk mengatasi kelemahannya. Metode penelitian adalah metode kuantitatif Teknik pengumpulan data yang digunakan adalah wawancara. Berdasarkan hasil analisa SWOT dan Value Chain menunjukkan PT Logistik Raya berada di kuadrat 1 (satu) pada posisi agresif dan strategi yang tepat yaitu strategi pertumbuhan. strategi yang digunakan sudah sesuai untuk pengembangan bisnis dengan mengutamakan strategi utama yaitu pelayanan (service). Dari sisi kinerja financial sebelum dan sesudah penerapan sinergitas pada PT Logistik Raya, yaitu sebelum adanya sinergitas yaitu sebelum Mei 2021 kinerja financial berasa diposisi minus atau rugi sebesar ( -20%, 025%) dan setelah pertengahan tahun 2021 kinerja keuangan berubah menjadi positif atau laba sebesar ( 5%, 17%) bahkan periode September 2023 mencapai 14% belum full satu tahun sampai dengan desember 2023. Strategi menerapkan program sinergitas sangat membawa pengaruh yang sangat menunjang terhadap hasil kinerja keuangan dan operasional PT Logistik Raya
An Overcorrective Modification of Cranial Vault Reconstruction for Non-Syndromic Metopic Suture Synostosis: Shiraz Technique
Authors: Masoudi Mohammad Sadegh , Zoghi Sina , Ansari Ali , Taherpour Sanaz , Shahriarirad Reza , Taheri Reza 
Published: May 2024

Objective: Growth restriction of frontal bones due to premature closure of metopic suture leads to the “Trigonon” shape of the skull, introduced by Welcker in 1862. Paul Tessier introduced cranial vault reconstruction (CVR), a common craniofacial procedure for treating this condition. The present study aims to introduce a modified version of this procedure.
Methods: In this study, we present our experience with a modified version of CVR, named the Shiraz technique, used as a single-stage overcorrective reconstructive method for isolated metopic suture synostosis with limited unique threesome osteotomies. We also report 35 cases treated with this technique.
Results: The patient population comprised 26 males (74.3%) and 9 females (25.7%) with a mean age of 8.4 months (range: 3-13). The mean duration of the operation and anesthesia was 175.0 minutes (range: 60-300). The mean intraoperative bleeding and blood transfusion volumes were 95.6 ml (range: 20-250) and 75.3 ml (range: 0-320), respectively. The main complications during the follow-up were epidural hematoma (n=3, 8.6%; one case needed reoperation), temporal hollowing (n=2, 5.7%), raised intracranial pressure (n=2, 5.7%), wound infection (n=2, 5.7%), and mortality in one of the cases, which was presumed to be due to air emboli.
Conclusions: The Shiraz technique, as a novel modified version of CVR, is a safe and effective technique for the treatment of non-syndromic metopic suture synostosis with low mean intraoperative blood loss and transfusion. In the long-term follow-up, the occurrence of temporal hollowing was decreased, and the outcome showed a smooth anterior skull base.
Concordance factors in craniosynostosis twins: a meta-analysis and case report
Authors: Da Cunha Artur Henrique Galvao Bruno , Guerra Pedro , Cysneiros Renata Raizza Monterazzo , Da Silva Inaê Carolline Silveira 
Published: May 2024

Introductions:
Craniosynostosis is a condition where the cranial sutures close prematurely. It is influenced by both genetics and environment. This paper focuses on craniosynostosis in twins, which is an understudied area. It presents a case report of male identical twins and conducts a meta-analysis based on 34 articles to understand the factors affecting concordance in twins who have craniosynostosis. The study considers factors such as zygosity, gender, genetic syndromes, and the type of synostosis.
Material and methods: A meta-analysis was conducted on 105 twin pairs (210 patients) identified from studies carried out between 1963 to 2023. The eligible studies, based on PICO criteria, included case reports and case series focusing on twins with craniosynostosis. A systematic literature search was conducted on PUBMED and Mendeley platforms to gather data on gestational age, zygosity, genetic syndromes, affected sutures, and concordance.
Results: The report is about two identical twin brothers who had sagittal and metopic suture synostosis. They were treated successfully with cranial remodeling surgery. In a meta-analysis of 105 twin pairs (210 patients) , a total of 25.9% showed concordance. The study found a significant difference in concordance between monozygotic (45.3%) and dizygotic (7.3%) twins. The analysis also revealed that twins with scaphocephaly had a higher degree of concordance than those with trigonocephaly (46.7% vs. 18.9%, respectively). The study did not find any significant correlation between gender, the presence of genetic syndromes, and concordance.
Conclusion: This investigation highlights the complex interplay of genetic and environmental factors in craniosynostosis in twins. The higher concordance in monozygotic twins emphasizes the genetic basis. These findings validate existing literature and provide new insights.
ANALISIS MAKNA DAN JENIS UNGKAPAN METAFORA DALAM LIRIK LAGU OST DREAM HIGH
Authors: Adinda Rurani 
Published: May 2024

ABSTRAKABSTRAK Penelitian ini membahas lingkup kajian semantik yang dilatar belakangi fenomena retorika pada penggunaan metafora yang terkandung dalam lirik lagu berbahasa Korea. Kumpulan lagu dari album ost DreamHigh suatu perasaan dalam perjalanan yang berproses untuk mencapai mimpi yang dikemas melalui lirik yang puitis dan bermakna dalam. Adapun penelitian ini bertujuan untuk menganalisis ungkapan metafora yangterdapat pada lirik lagu ost Dream High untuk menemukan maknanya berdasarkan teori dari Lakoff dan Johnson. Metode yang digunakan dalam penelitian ini adalah metode analisis kualitatif deskriptif dengan teknik simak catat. Hasil analisis menemukan bahwa terdapat 1 larik metafora orientasional, 7 larik metafora struktural, dan 4 larik metafora ontologis, dengan dominan menggunakan metafora struktural didalam liriknya. Salah satu ungkapan metafora yang ditemukan adalah frasa ‘먼지/meonji’ yang terdapat dalam lagu yang berjudul ‘Dream High’, yakni “먼지를 털고/meonjireul theolgo”, yang diartikan “kukibaskan debu (di celana saat ku terjatuh)”.Frasa ‘먼지/meonji’ ini dianalogikan dengan ‘sebuah kegagalan’. Kata Kunci: Metafora, Ost Dream High, Lakoff dan Johnson, Makna, Ungkapan, Lirik Lagu ABSTRACTABSTRACT This research discusses the scope of semantic studies based on rhetorical phenomena in the use of metaphors contained in Korean song lyrics. A collection of songs from the ost album Dream High, a feeling ofbeing on a journey in the process of achieving a dream, packaged through poetic and deeply meaningful lyrics. This research aims to analyze the metaphorical expressions contained in the lyrics of the ost Dream High song to find their meaning based on the theory of Lakoff and Johnson. The method used in this research is a descriptive qualitative analysis method using note-taking techniques. The results of the analysis found that there was 1 array of orientational metaphors, 7 arrays of structural metaphors, and 4 arrays of ontological metaphors, with the dominant use of structural metaphors in the lyrics. One of the metaphorical expressions found is the phrase '먼지/meonji' which is found in the song entitled 'Dream High', namely "먼지를 털고/meonjireul theolgo", which is translated as "I shake off the dust (on my trousers when I fall)". The phrase '먼지/meonji' is analogous to 'a failure'. Keywords: Metaphor, Ost Dream High, Lakoff and Johnson, Meaning, Phrases, Song Lyrics