bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel anti‐inflammatory role for secretory phospholipase A2 in immune complex‐mediated arthritis
Authors: Boilard Eric , Lai Ying , Larabee Katherine , Balestrieri Barbara , Ghomashchi Farideh , Fujioka Daisuke , Gobezie Reuben , Coblyn Jonathan S. , Weinblatt Michael E. , Massarotti Elena M. , Thornhill Thomas S. , Divangahi Maziar , Remold Heinz , Lambeau Gérard , Gelb Michael H. , Arm Jonathan P. , Lee David M. 
Published: April 2010

AbstractPhospholipase A2 (PLA2) catalyses the release of arachidonic acid for generation of lipid mediators of inflammation and is crucial in diverse inflammatory processes. The functions of the secretory PLA2 enzymes (sPLA2), numbering nine members in humans, are poorly understood, though they have been shown to participate in lipid mediator generation and the associated inflammation. To further understand the roles of sPLA2 in disease, we quantified the expression of these enzymes in the synovial fluid in rheumatoid arthritis and used gene‐deleted mice to examine their contribution in a mouse model of autoimmune erosive inflammatory arthritis. Contrary to expectation, we find that the group V sPLA2 isoform plays a novel anti‐inflammatory role that opposes the pro‐inflammatory activity of group IIA sPLA2. Mechanistically, group V sPLA2 counter‐regulation includes promotion of immune complex clearance by regulating cysteinyl leukotriene synthesis. These observations identify a novel anti‐inflammatory function for a PLA2 and identify group V sPLA2 as a potential biotherapeutic for treatment of immune‐complex‐mediated inflammation.
A numerical study on response factors for steel wall–frame systems
Authors: Arslan Hakan , Topkaya Cem 
Published: April 2010

AbstractA numerical investigation was undertaken to evaluate the response of dual structural systems that consisting of steel plate shear walls and moment‐resisting frames. The primary objective of the study was to investigate the influence of elastic base shear distribution between the wall and the frame on the global system response. A total of 10 walls and 30 wall–frame systems, ranging from 3 to 15 stories, were selected for numerical assessment. These systems represent cases in which the elastic base shear resisted by the frame has a share of 10, 25, or 50% of the total base shear resisted by the dual system. The numerical study consisted of 1600 time history analyses employing three‐dimensional finite elements. All 40 structures were separately analyzed for elastic and inelastic response by subjecting them to the selected suite of earthquake records. Interstory drifts, top story drift, base shears resisted by the wall, and the frame were collected during each analysis. Based on the analysis results, important response quantities, such as the strength reduction, the overstrength, and the displacement amplification factors, are evaluated herein. Results are presented in terms of displacement measures, such as the interstory drift ratio and the top story drift ratio. Analysis results revealed that the increase in the strength reduction factor with the amount of load share is insignificant. Furthermore, there is an inverse relationship between the ductility reduction and the overtsrength. Copyright © 2010 John Wiley & Sons, Ltd.
Bayesian model selection for ARX models and its application to structural health monitoring
Authors: Saito Tomoo , Beck James L. 
Published: April 2010

AbstractA Bayesian framework for model order selection of auto‐regressive exogenous (ARX) models is developed and applied to actual earthquake response data obtained by the structural health monitoring system of a high‐rise building. The model orders of ARX models are selected appropriately by the Bayesian framework, and differ significantly from the optimal order estimated by AIC; in fact, in many cases AIC does not even give an optimal order. A method is also proposed for consistently selecting the same ‘genuine’ modes of interest from the whole set of modes corresponding to each of the identified models from a sequence of earthquake records. In the identification analysis based on building response records from 43 earthquakes over 9 years, the modal parameters of the first four modes in each horizontal direction are estimated appropriately in all cases, showing that the developed methods are effective and robust. As the estimates of natural frequency depend significantly on the response amplitude, they are compensated by an empirical correction so that the influence of the response amplitude is removed. The compensated natural frequencies are much more stable over the nine‐year period studied, indicating that the building had no significant change in its global dynamic characteristics during this period. Copyright © 2010 John Wiley & Sons, Ltd.
Probabilistic evaluation of soil–foundation–structure interaction effects on seismic structural response
Authors: Moghaddasi Masoud , Cubrinovski Misko , Chase J. Geoff , Pampanin Stefano , Carr Athol 
Published: April 2010

AbstractComplex seismic behaviour of soil–foundation–structure (SFS) systems together with uncertainties in system parameters and variability in earthquake ground motions result in a significant debate over the effects of soil–foundation–structure interaction (SFSI) on structural response. The aim of this study is to evaluate the influence of foundation flexibility on the structural seismic response by considering the variability in the system and uncertainties in the ground motion characteristics through comprehensive numerical simulations. An established rheological soil‐shallow foundation–structure model with equivalent linear soil behaviour and nonlinear behaviour of the superstructure has been used. A large number of models incorporating wide range of soil, foundation and structural parameters were generated using a robust Monte‐Carlo simulation. In total, 4.08 million time‐history analyses were performed over the adopted models using an ensemble of 40 earthquake ground motions as seismic input. The results of the analyses are used to rigorously quantify the effects of foundation flexibility on the structural distortion and total displacement of the superstructure through comparisons between the responses of SFS models and corresponding fixed‐base (FB) models. The effects of predominant period of the FB system, linear vs nonlinear modelling of the superstructure, type of nonlinear model used and key system parameters are quantified in terms of different probability levels for SFSI effects to cause an increase in the structural response and the level of amplification of the response in such cases. The results clearly illustrate the risk of underestimating the structural response associated with simplified approaches in which SFSI and nonlinear effects are ignored. Copyright © 2010 John Wiley & Sons, Ltd.
Disturbance of perfluorooctanoic acid on development and behavior in Drosophila larvae
Authors: Wang Jianshe , Li Yan , Liu Yang , Zhang Hongxia , Dai Jiayin 
Published: April 2010

Abstract
Perfluorooctanoic acid (PFOA) is a well-known perfluorinated compound (PFC), and its toxicological impact is currently of worldwide concern. In this study, we sought to evaluate the potential biological effects and modes of action of PFOA in a range of physiologically and developmentally related phenotypes in the fruit fly Drosophila melanogaster. The results clearly indicated that the toxic effects of PFOA at the organismal level were associated with the developmental status of the organism, with larvae being most sensitive to this chemical. Except for the decreased weight of both sexes and the reduced longevity of male adults, PFOA had a robust effect on larval development, as determined by reduced body volume, aberrant foraging behavior, molting arrest, and polyphasic lethality. Remarkably, nutrient supplementation of the diet efficiently rescued the lethal effect of high PFOA concentrations on larval development. This result indicated that PFOA probably competed with nutritional components, leading to a disruption of the metabolic pathways responsible for larval development. Environ. Toxicol. Chem. 2010;29:2117–2122. © 2010 SETAC
Heat and moisture exchange capacity of the upper respiratory tract and the effect of tracheotomy breathing on endotracheal climate
Authors: Scheenstra Renske J. , Muller Sara H. , Vincent Andrew , Hilgers Frans J. M. 
Published: April 2010

AbstractBackgroundThe aim of this study was to assess the heat and moisture exchange (HME) capacity of the upper respiratory tract and the effect of tracheotomy breathing on endotracheal climate in patients with head and neck cancer.MethodsWe plotted the subglottic temperature and humidity measurements in 10 patients with head and neck cancer with a temporary precautionary tracheotomy during successive 10‐minute periods of nose, mouth, and tracheotomy breathing in a randomized sequence.ResultsEnd‐inspiratory temperatures of nose, mouth, and tracheotomy breathing were 31.1, 31.3, and 28.3°C, respectively. End‐inspiratory humidity measurements of nose, mouth, and tracheotomy breathing were 29.3, 28.6, and 21.1 mgH2O/L, respectively. There was a trend toward lower end‐inspiratory humidity in patients with radiotherapy or with large surgery‐induced oropharyngeal mucosal defects, whereas temperatures were similar.ConclusionThis study gives objective information about the HME capacity of the upper respiratory tract in patients with head and neck cancer with precautionary tracheotomy, and thus provides target values for HMEs for laryngectomized and tracheotomized patients. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Entry kinetics and cell–cell transmission of surface‐bound retroviral vector particles
Authors: O'Neill Lee S. , Skinner Amy M. , Woodward Josha A. , Kurre Peter 
Published: April 2010

AbstractBackgroundTransduction with recombinant HIV‐1 derived lentivirus vectors is a multi‐step process initiated by surface attachment and subsequent receptor‐directed uptake into the target cell. We previously reported the retention of vesicular stomatitis virus G protein pseudotyped particles on murine progenitor cells and their delayed cell–cell transfer.MethodsTo examine the underlying mechanism in more detail, we used a combination of approaches focused on investigating the role of receptor‐independent factors in modulating attachment.ResultsThe investigation of synchronized transduction reveals cell‐type specific rates of vector particle clearance with substantial delays during particle entry into murine hematopoietic progenitor cells. The observed uptake kinetics from the surface of the 1° cell correlate inversely with the magnitude of transfer to 2° targets, corresponding with our initial observation of preferential cell–cell transfer in the context of brief vector exposures. We further demonstrate that vector particle entry into cells is associated with the cell‐type specific abundance of extracellular matrix fibronectin. Residual particle–extracellular fibronectin matrix binding and 2° transfer can be competitively disrupted by heparin exposure without affecting murine progenitor homing and repopulation.ConclusionsAlthough cellular attachment factors, including fibronectin, aid gene transfer by colocalizing particles to cells and disfavoring early dissociation from targets, they also appear to stabilize particles on the cell surface. The present study highlights the inadvertent consequences for cell entry and cell–cell transfer. Copyright © 2010 John Wiley & Sons, Ltd.
Betulin and its natural resource as potential anticancer drug candidate seen by FT‐Raman and FT‐IR spectroscopy
Authors: Fǎlǎmaş A. , Pînzaru S. Cîntǎ , Dehelean C. A. , Peev C. I. , Soica C. 
Published: April 2010

AbstractThe Fourier transform Raman and IR spectra of betulin (lup‐20(29)‐ene‐3β,28‐diol) crystalline powder were recorded and analyzed. The vibrational wavenumbers and the corresponding vibrational assignments were theoretically studied using the Gaussian 03 package. The calculated vibrational wavenumbers with the B3LYP density functionals are generally consistent with the observed spectra. A complete vibrational characterization of betulin modes has been proposed here for the first time. Based on the vibrational analysis, two direct applications of the results have been described. It was shown that the outer bark of Betula Pendula Roth (the birch tree) contains betulin as a major component along with minor amounts of betulinic acid (BA), lupeol and other pentacyclic triterpenes derivatives. Since the major disadvantage of betulin is its low solubility, giving rise to serious problems in making pharmaceutical formulations, several guest–host type of complexes of betulin–cyclodextrins have been prepared and analyzed using FT‐Raman spectroscopy. Based on the vibrational analysis, it was concluded that the OH and CH2OH functional groups are free from chemical interactions with the cyclodextrin cavity. Copyright © 2010 John Wiley & Sons, Ltd.
Absolute measurement of internal volume changes inside the pulse damper: Discrepancy between delay and dwell volumes
Authors: Rogatsky Eduard , Zheng Zheng , Stein Daniel 
Published: April 2010

AbstractWe have developed a novel technique for the absolute determination of the mobile phase volume stored inside of a variable volume pulse damper at different pressures. Using an Agilent HPLC pulse damper we found a linear volume increase of ∼1 μL/bar. We found that pump pressurization is a relatively slow process and takes ∼1 min to reach 90% and takes ∼2 min to reach 99% equilibration at flow rates below 1 mL/min. During pump pressurization, column flow rate will be less than the pre‐set, since part of the mobile phase is retained inside of the pulse damper. During our experiments we observed a discrepancy between data obtained by UV techniques and direct absolute measurements. This difference can be explained by a fundamental difference between the gradient delay volume and dead (dwell) volume.
Bounding the error for approximate solutions of almost linear complementarity problems using feasible vectors
Authors: Alefeld Götz , Wang Zhengyu 
Published: April 2010

AbstractIn this paper we use the concept of a feasible vector in order to bound a solution x* of an almost linear complementarity problem in a certain set. This set delivers also componentwise error bounds for an approximation to a solution x*. In the special case that the problem is defined by a so‐called H‐matrix, we prove that the error bounds are more accurate than the corresponding bounds recently obtained. By numerical examples it will be demonstrated that the new bounds can be better by several orders of magnitude. Copyright © 2010 John Wiley & Sons, Ltd.
Synthesis, characterization of naphthalene‐based polyimides, and their use as immobilized enzyme membrane
Authors: Paşahan Aziz , Köytepe Süleyman , Ekinci Ergun 
Published: April 2010

AbstractA new monomer, 1,5‐bis(p‐dimethylaminophenylimino)naphthalene, was prepared through Schiff‐base condensation reaction of 1,5‐diaminonaphthalene and 4‐(dimethylamino)benzaldehyde in the presence of ethanol. A series of aromatic polyimides bearing naphthalene and CHN groups were synthesized from the diamine with five kinds of commercial dianhydrides via a conventional one‐stage process. The resulting naphthalene based polyimides (NBPs) showed good solubilities in N‐methyl‐2‐pyrrolidone and m‐cresol. NBPs had glass‐transition temperatures at 139–174°C and 10% weightloss temperatures above 430 °C in nitrogen atmospheres. Excellent properties of NBPs are attributed to the incorporation of the naphthalene and CHN group in 1,5‐bis(p‐dimethylaminophenylimino)naphthalene. Moreover, chemically prepared polyimides were used for immobilization of glucose oxidase (GOx). The amperometric responses of the NBPs‐GOx‐Pt electrodes toward glucose were examined at a potential of 0.7 V in PBS solution by means of time‐base (TB) technique. Results show that NBPs bearing O group membrane (PI‐3) has many advantages in the immobilization of glucose oxidase because of its strong adherence to electrode surface and chemical stability and selectivity. Copyright © 2010 John Wiley & Sons, Ltd.
Childhood, adolescent, and young adult cancer survivors research program of British Columbia: Objectives, study design, and cohort characteristics
Authors: McBride Mary L. , Rogers Paul C. , Sheps Sam B. , Glickman Victor , Broemeling Anne‐Marie , Goddard Karen , Hu Joan , Lorenzi Maria , Peacock Stuart , Pritchard Sheila , Rassekh Shahrad Rod , Siegel Linda , Spinelli John J. , Teckle Paulos , Xie Lijing 
Published: April 2010

AbstractBackgroundThe Childhood, Adolescent, and Young Adult Cancer Survivors Research Program (CAYACS) has been established in the province of British Columbia (BC), Canada, to carry out research into late effects and survivor care in multiple domains, and to inform policy and practice.ProcedureThis program identifies a survivor cohort and comparison groups from population‐based registries and links their records to population‐based files of outcomes and outcome determinants, to create a research database and conduct studies of long‐term outcomes and care.ResultsThe initial cohort consisted of all 5‐year survivors of cancer or a tumor diagnosed under age 25 years from 1970 to 1995, who were residents in BC at the time of diagnosis, and followed till 2000 (3,841 subjects). Seven percent have died, and 77% have treatment information available. Data on death and second cancer occurring in BC are available. Late morbidity and healthcare utilization information is available for 68% of survivors (79% of those diagnosed from 1981). Education outcomes are available for 71% of those born during 1978–1995 and diagnosed under age 15 years.ConclusionsUse of registries, administrative databases, and record linkage methodologies is a cost‐effective and comprehensive means to conduct survivorship research. This program should add to knowledge of risks of late effects and impacts on care, inform development of strategies to manage risks, evaluate the effects of surveillance and interventions, and assess new risks as the cohort ages, more recent survivors enter the cohort, and treatments change. Pediatr Blood Cancer. 2010;55:324–330. © 2010 Wiley–Liss, Inc.
Simultaneous analysis of three bioactive compounds in Artemisia annua hairy root cultures by reversed‐phase high‐performance liquid chromatography–diode array detector
Authors: Zhai Dan‐Dan , Zhong Jian‐Jiang 
Published: April 2010

AbstractIntroduction – Artemisia annua is a rich source of biologically active substances such as terpenoids, coumarins and polyacetylenes. These chemicals have been reported to show beneficial pharmacological properties such as antitumor and antibacterial activities. In genetically transformed root cultures of A. annua, three bioactive metabolites, namely, ponticaepoxide (an insecticidal polyacetylene, 1), drimartol A (an anticancer sesquiterpene coumarin, 2) and (Z)‐7‐acetoxy‐methyl‐11‐methyl‐3‐methylene‐dodeca‐1,6,10‐triene (a new anticancer sesquiterpene, 3) were isolated and identified in our recent work. However, no quantitative analysis methods for any of them are yet available, nor for their simultaneous analysis.Objective – To develop an HPLC‐PAD method for simultaneous determination of 1, 2 and 3 in hairy root cultures of A. annua.Methodology – HPLC operating conditions were optimised and the chromatographic separation was performed on a C18 column with a gradient acetonitrile : water as mobile phase.Results – Linear relationships within the range of investigated concentrations were observed for the three metabolites with their correlation coefficients greater than 0.997. The method was validated for repeatability (RSD <3.59%) and intra‐ and inter‐day precision (RSD <3.1%) with recovery between 94.8 and 107.6% and the RSD less than 3.40%. The method was successfully applied to the time‐course of accumulation of the bioactive compounds in genetically transformed root cultures of A. annua.Conclusion – The HPLC‐PAD method developed for the simultaneous determination of three bioactive metabolites 1, 2 and 3 was simple, reproducible and sensitive. Copyright © 2010 John Wiley & Sons, Ltd.
Exploring global meaning in Greek breast cancer patients: validation of the Life Attitude Profile—Revised (LAP‐R)
Authors: Anagnostopoulos Fotios , Slater Julie , Fitzsimmons Deborah , Kolokotroni Philippa 
Published: April 2010

AbstractObjective: The aim of this study was to examine the factor structure and the psychometric properties of the Life Attitude Profile—Revised (LAP‐R) among a sample of Greek breast cancer patients, and to test the fit of a structural equation model with one latent factor underlying the measured LAP‐R dimensions.Methods: A total of 153 patients with breast cancer completed the LAP‐R. Convergent validity was assessed by examining the correlations between the LAP‐R subscales and measures of perceived stress, intrusiveness, mental health, and coping styles. Known‐groups validity was also assessed.Results: Principal axis factor analysis with promax rotation yielded four factors: purpose–coherence–vacuum, choice, death acceptance, and goal seeking. Internal consistency reliability of the subscales and convergent validity of LAP‐R were satisfactory. LAP‐R was able to detect differences in meaning between different age groups. Confirmatory factor analysis provided support for a single‐factor model including a latent meaning‐variable indicated by the observed subscales.Conclusions: The LAP‐R is a reliable and valid measure of global meaning in life, when administered to breast cancer patients. The use of LAP‐R in evaluating meaning‐centered psychotherapy interventions for patients with cancer is emphasized. Copyright © 2010 John Wiley & Sons, Ltd.
Magnetotunneling into Fock–Darwin‐like quantum dot states: Lateral matrix elements and the role of selection rules
Authors: Kießlich Gerold 
Published: April 2010

AbstractWe study theoretically the magnetotunneling transport through quantum dots formed by thermal diffusion of charged manganese interstitials in the vicinity of a GaAs quantum well [Phys. Rev. Lett. 101, 226807 (2008)]. In particular, we examine the lateral matrix elements between Landau subbands in the contact and Fock–Darwin‐like states of an individual dot at high magnetic fields. We explicitly demonstrate the effect of spatial deformation of the dot on the wave function's overlap. The comparison with measured data suggests a selection rule similar to angular momentum conservation for tunneling into perfect Fock–Darwin states. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)