bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a sensitive method for simultaneous determination of fluticasone propionate and salmeterol in plasma samples by liquid chromatography‐tandem mass spectrometry
Authors: Silvestro Luigi , Savu Simona Rizea , Savu Simona Nicoleta , Tudoroniu Ariana , Tarcomnicu Isabela 
Published: October 2011

ABSTRACTA new method for the fast simultaneous quantification of fluticasone propionate and salmeterol from plasma samples by liquid chromatography–tandem mass spectrometry, with adequate sensitivity for pharmacokinetic applications, was developed and validated. The chromatographic separation and mass‐spectrometric parameters were optimized for the retention and detection of the two compounds, despite quite different structures and properties. Two columns connected in series were used, cation‐exchange (Zorbax 300‐SCX, 5 cm × 2.1 mm, 5 µm) and octadecyl (Discovery HSC18, 10 cm × 2.1 mm, 5 µm). The mass‐spectrometric interface was operated in negative electrospray ionization mode; high sensitivity and lesser matrix effects were obtained, permitting smaller consumption of plasma. The sample preparation was based on supported liquid–liquid extraction in 96‐well format plates that provided clean samples with a simplified procedure that was suitable for automation. The method was validated according to regulatory guidelines, by assessing lower limits of quantification, selectivity, linearity, accuracy, precision, extraction recoveries and matrix effects. A comparison with two other methods for the separate determination of fluticasone propionate and salmeterol in plasma samples, previously developed by our group, is presented. The statistical evaluation of the results obtained with the three methods on a set of unknown samples from treated patients demonstrated good correlation (R2 0.987 for fluticasone propionate and 0.967 for salmeterol). Copyright © 2011 John Wiley & Sons, Ltd.
Rapid determination and comparative pharmacokinetics of tetrahydropalmatine in spontaneously hypertensive rats and normotensive rats
Authors: Hong Zhanying , Cai Guojun , Ma Wentao , Wen Jun , Chai Yifeng , Fan Guorong 
Published: October 2011

ABSTRACTA rapid high‐performance liquid chromatographic method was developed and validated for determination of tetrahydropalmatine (THP), an active component of Rhizoma Corydalis, in rat plasma. The samples were prepared using protein precipitation and separated on an Agilent XDB‐C18 column (150 × 4.6 mm, 5 µm) with the mobile phase consisting of methanol–0.1% phosphate acid solution, adjusted with triethylamine to pH 5.5 (65:35). Good linearity was found within 0.10–10.00 µg/mL of THP in rat plasma sample. The intra‐ and inter‐day precision values were less than 10%. The developed method was successfully applied to assess the pharmacokinetics of THP in spontaneously hypertensive rats (SHR) and normotensive rats. After oral administration of a single dose of THP (60 mg/kg), the maximum plasma concentrations were 6.15 ± 2.1 and 7.54 ± 2.9 µg/mL for normotensive rats and SHR, respectively. The mean values of AUC0–∞ of THP in SHR were 81.44 ± 45.0 µg h/mL, significantly higher (p < 0.05) than in normotensive rats (44.06 ± 19.6 µg h/mL). The t1/2 and MRT in SHR were much longer than that in healthy Sprague–Dawley rats, indicating slow elimination of THP in SHR. The results indicated that there are some differences in pharmacokinetics of THP in SHR and Sprague–Dawley rats and it is very important to investigate the pharmacokinetic properties of drugs in pathological conditions. Copyright © 2011 John Wiley & Sons, Ltd.
Primary percutaneous coronary intervention for acute myocardial infarction in the elderly aged ≥75 years
Authors: Sakai Koyu , Nagayama Shinya , Ihara Kasumi , Ando Kenji , Shirai Shinichi , Kondo Katsuhiro , Yokoi Hiroyoshi , Iwabuchi Masashi , Nosaka Hideyuki , Nobuyoshi Masakiyo 
Published: October 2011

AbstractObjectives: We aimed to see whether primary percutaneous coronary intervention (PCI) benefits for ST‐segment elevation myocardial infarction (STEMI) in the aged could be validated. Background: Primary PCI benefits in elderly patients with STEMI remain uncertain. Methods: We reviewed 947 consecutive patients treated with primary PCI for STEMI: 331 were aged ≥75 years (older) and 616 <75 years (younger). Results: The older group had higher percentage of renal insufficiency (7.9% vs. 3.1%, P = 0.0010), prior stroke (9.4% vs. 3.9%, P = 0.0006), 30‐day mortality rate (7.6% vs. 3.9%, P = 0.015), and cardiac mortality rate (6.6% vs. 3.7%, P = 0.045). Successful reperfusion rates were similarly high in both groups (90.0% and 92.7%, P = 0.16), despite the higher proportion of patients with door‐to‐balloon time >90 min (15% vs. 8.4%, P = 0.0016) in older patients. Successful compared with unsuccessful PCI significantly decreased 30‐day mortality rates in the older group (6.0% vs. 21%, P = 0.0018) and in the younger group (2.8% vs. 18%, P < 0.0001). When reperfusion was successful, cardiac mortality rate in older patients was not significantly greater than in younger patients (5.4% vs. 2.8%, P = 0.057). By multivariate analysis, unsuccessful reperfusion independently predicted 30‐day mortality (odds ratio, 4.04; 95% confidence interval, 1.79–9.12; P = 0.0008), whereas age ≥75 years (odds ratio, 1.00; 95% confidence interval, 0.41–2.41; P = 0.99) and door‐to‐balloon time >90 min (odds ratio, 1.78; 95% confidence interval, 0.76–4.20; P = 0.19) did not. Conclusions: Pre‐existing comorbidities characterize older patients developing STEMI. Aggressive PCI in older patients improves prognosis, and short door‐to‐balloon time is an important parameter conditioning the prognosis. © 2011 Wiley Periodicals, Inc.
The retrograde approach to coronary artery chronic total occlusions
Authors: Brilakis Emmanouil S. , Grantham J. Aaron , Thompson Craig A. , DeMartini Tony J. , Prasad Abhiram , Sandhu Gurpreet S. , Banerjee Subhash , Lombardi William L. 
Published: October 2011

AbstractThe retrograde approach has revolutionized the treatment of chronic total occlusions. Several retrograde techniques have recently been described. In this article, we present a practical review with step‐by‐step instructions on the indications for retrograde interventions, equipment and retrograde channel selection, and techniques for retrograde crossing and treatment of chronic total occlusions. © 2011 Wiley Periodicals, Inc
Proximal and distal maximal luminal diameters as a guide to appropriate deployment of the ABSORB everolimus‐eluting bioresorbable vascular scaffold
Authors: Farooq Vasim , Gomez‐Lara Josep , Brugaletta Salvatore , Gogas Bill D. , Garcìa‐Garcìa Hector M. , Onuma Yoshinobu , van Geuns Robert Jan , Bartorelli Antonio , Whitbourn Robert , Abizaid Alexandre , Serruys Patrick W. 
Published: October 2011

AbstractObjectives: Due to the limited distensibility of the everolimus‐eluting bioresorbable vascular scaffold (ABSORB) compared to metallic platform stents, quantitative coronary arteriography (QCA) is a mandatory requirement for ABSORB deployment in the on‐going ABSORB EXTEND Single‐Arm Study. Visual assessment of vessel size in the ABSORB Cohort B study often lead to under and over‐sizing of the 3 mm ABSORB in coronary vessels (recommended range of the vessel diameter ≥2.5 mm and ≤3.3 mm), with an increased risk of spontaneous incomplete scaffold apposition post ABSORB deployment. We report whether mandatory QCA assessment of vessel size pre‐implantation, utilizing the maximal luminal diameter (Dmax) and established interpolated reference vessel diameter (RVD) measurements, has improved device/vessel sizing. Methods: Pre‐implantation post‐hoc QCA analyses of all 101 patients from ABSORB Cohort B (102 lesions) and first consecutive 101 patients (108 lesions) from ABSORB EXTEND were undertaken by an independent core‐laboratory; all patients had a 3 mm ABSORB implanted. Comparative analyses were performed. Results: Within ABSORB Cohort B, a greater number of over‐sized vessels (>3.3 mm) were identified utilizing the Dmax compared to the interpolated RVD (17 vessels, 16.7% vs. 3 vessels, 2.9%; P = 0.002). Comparative analyses demonstrated a greater number of appropriate vessel‐size selection (75 vessels, 69.4% vs. 48 vessels, 47.1%; P = 0.001), a trend towards a reduction in implantation in small (<2.5 mm) vessels (29 vessels, 26.9% vs. 40 vessels, 39.2%; P = 0.057) and a significant decrease in the implantation in large (>3.3 mm) vessels (4 vessels, 3.7% vs. 17 vessels, 16.7%; P = 0.002) in ABSORB EXTEND. Bland–Altman plots suggested a good agreement between operator and core‐laboratory calculated Dmax measurements. Conclusions: The introduction of mandatory Dmax measurements of vessel size prior to ABSORB implantation significantly reduced the under‐sizing of the 3.0 mm scaffold in large vessels validating the use of this technique in vessel sizing prior to ABSORB implantation. © 2011 Wiley Periodicals, Inc.
Continuous Gas‐Phase Hydroformylation of a Highly Diluted Technical C4 Feed using Supported Ionic Liquid Phase Catalysts
Authors: Haumann Marco , Jakuttis Michael , Franke Robert , Schönweiz Andreas , Wasserscheid Peter 
Published: October 2011

AbstractThe concept of supported ionic liquid phase (SILP) catalysis has been established in recent years by our group and others. Its application in continuous catalytic gas‐phase processes provides a very attractive way to bridge the gap between homogeneous and heterogeneous catalysis. In this contribution, we extend SILP hydroformylation catalysis to reactions with a highly diluted, technical C4 feed containing 1.5 % 1‐butene, 28.5 % 2‐butenes, and 70 % of inert n‐butane. To obtain the desired product, n‐pentanal, the Rh‐biphephos catalyst system was immobilized in the SILP system to allow for consecutive isomerization/hydroformylation activity. The resulting SILP catalyst material converted up to 81 % of the reactive butenes, with a residence time of 155 s in the reactor. An n‐pentanal selectivity greater than 92 % was realized for more than 500 h time‐on‐stream in the continuous gas‐phase reaction. Post‐reaction NMR studies revealed no significant loss of the phosphite ligand through ligand oxidation during the reaction.
Unsymmetrically Substituted 9,10‐Dihydro‐9,10‐diboraanthracenes as Versatile Building Blocks for Boron‐Doped π‐Conjugated Systems
Authors: Januszewski Estera , Lorbach Andreas , Grewal Rekha , Bolte Michael , Bats Jan W. , Lerner Hans‐Wolfram , Wagner Matthias 
Published: October 2011

AbstractThe targeted hydrolysis of the 9,10‐dihydro‐9,10‐diboraanthracene adduct (Me2S)HB(C6H4)2BH(SMe2) (1) with 0.5 equiv of H2O leads to formation of the borinic acid anhydride [(Me2S)HB(C6H4)2B]2O (2) and thereby provides access to the field of unsymmetrically substituted 9,10‐dihydro‐9,10‐diboraanthracenes. Compound 2 reacts with tBuCCH to give the corresponding vinyl derivative in an essentially quantitative conversion. Subsequent cleavage of the B‐O‐B bridge by LiAlH4 with formation of hydridoborate functionalities is possible but is accompanied by partial BC(vinyl) bond degradation. This situation changes when the related mesityl derivative [MesB(C6H4)2B]2O (7) is employed, which can be synthesized from BrB(C6H4)2BBr (6) by treatment with 1 equiv of MesMgBr and subsequent hydrolysis. The reaction of 7 with LiAlH4 in tetrahydrofuran (THF) furnishes Li[MesB(C6H4)2BH2] (8); hydride elimination with Me3SiCl leads to formation of the THF adduct MesB(C6H4)2BH(THF) (9⋅THF). Alternatively, 7 can be transformed into the bromoborane MesB(C6H4)2BBr (10) by treatment with BBr3. A Br/H‐exchange reaction between 10 and Et3SiH yields the donor‐free borane MesB(C6H4)2BH (9), which forms B‐H‐B bridged dimers (9)2 in the solid state. The vinyl borane MesB(C6H4)2BC(H)C(H)Mes (14) is accessible from MesCCH and either 9⋅THF or 9. Compared with the related compound Mes2BC(H)C(H)Mes, the electronic absorption and emission spectra of 14 reveal bathochromic shifts of Δλ(abs)=17 nm and Δλ(em)=74 nm, which can be attributed to the rigid, fully delocalized π framework of the [MesB(C6H4)2B] chromophore.
Die vielen Gesichter des Poly(ethylenglykol)s
Authors: Dingels Carsten , Schömer Martina , Frey Holger 
Published: October 2011

AbstractPoly(ethylenglykol) ist in unserem Leben allgegenwärtig. Wir begegnen diesem biokompatiblen und hervorragend wasserlöslichen Polymer, meist ohne dass uns dies bewusst ist, in fast allen Bereichen des alltäglichen Bedarfs: Von Haut‐ und Haarpflegeartikeln, über Kosmetik‐ und Styling‐Produkten bis hin zu Lebensmitteln und Medikamenten. Selbst in der maritimen Militärtechnologie und bei der Konservierung geborgener Kulturgüter wird es eingesetzt. Dieser Artikel beschäftigt sich mit der Darstellung, den teils überraschenden Eigenschaften und der Anwendung dieses strukturell simplen, aber faszinierend vielseitigen Polymers.
Nass oder trocken: Änderung der Benetzung je nach Zucker
Authors: Harrer Roswitha 
Published: October 2011

AbstractChiralität zu induzieren oder etwas durch Chiralität zu beeinflussen, ist immer eine Herausforderung. In Polymerfilme lassen sich chirale Moleküle hineinbringen, die andere chirale Moleküle erkennen. Erkannt, gebannt – und verändert: Ein dünnes Copolymer wechselte sein Benetzungsverhalten, indem es chirale Zuckermoleküle selektiv band.
Schüler und Lehrer sollen experimentieren
Authors: Meichsner Beate 
Published: October 2011

AbstractGut 19 Millionen Euro war der chemischen Industrie in den letzten zehn Jahren ein guter experimenteller Chemieunterricht wert. Die “Schulpartnerschaft Chemie” des Fonds der Chemischen Industrie (FCI) ist damit eine wesentliche Stütze dieses Unterrichtsfaches in Deutschland – und wird es auch bleiben. Denn für 2012 ist diese Partnerschaft gesichert und soll auch darüber hinaus fortgesetzt werden, so der FCI‐Geschäftsführer, Dr. Gerd Romanowski. “Das Geld ist gut investiert: Denn mit guter Bildung können wir eine nachhaltige Rendite für die gesamte Gesellschaft erzielen.”
Disturbance of reactive oxygen species homeostasis induces atypical tubulin polymer formation and affects mitosis in root‐tip cells of Triticum turgidum and Arabidopsis thaliana
Authors: Livanos Pantelis , Galatis Basil , Quader Hartmut , Apostolakos Panagiotis 
Published: October 2011

AbstractIn this study, the effects of disturbance of the reactive oxygen species (ROS) homeostasis on the organization of tubulin cytoskeleton in interphase and mitotic root‐tip cells of Triticum turgidum and Arabidopsis thaliana were investigated. Reduced ROS levels were obtained by treatment with diphenylene iodonium (DPI) and N‐acetyl‐cysteine, whereas menadione was applied to achieve ROS overproduction. Both increased and low ROS levels induced: (a) Macrotubule formation in cells with low ROS levels and tubulin paracrystals under oxidative stress. The protein MAP65‐1 was detected in treated cells, exhibiting a conformation comparable to that of the atypical tubulin polymers. (b) Disappearance of microtubules (MTs). (c) Inhibition of preprophase band formation. (d) Delay of the nuclear envelope breakdown at prometaphase. (e) Prevention of perinuclear tubulin polymer assembly in prophase cells. (f) Loss of bipolarity of prophase, metaphase and anaphase spindles. Interestingly, examination of the A. thaliana rhd2/At respiratory burst oxidase homolog C (rbohc) NADPH oxidase mutant, lacking RHD2/AtRBOHC, gave comparable results. Similarly to DPI, the decreased ROS levels in rhd2 root‐tip cells, interfered with MT organization and induced macrotubule assembly. These data indicate, for first time in plants, that ROS are definitely implicated in: (a) mechanisms controlling the assembly/disassembly of interphase, preprophase and mitotic MT systems and (b) mitotic spindle function. The probable mechanisms, by which ROS affect these processes, are discussed. © 2011 Wiley Periodicals, Inc.
Brilliant Triboluminescence of a Lanthanide Coordination Polymer with Low‐Vibrational‐Frequency and Non‐Centrosymmetric Structural Networks
Authors: Hasegawa Yasuchika , Hieda Ryo , Miyata Kohei , Nakagawa Tetsuya , Kawai Tsuyoshi 
Published: October 2011

AbstractCharacteristic triboluminescence from a lanthanide coordination polymer with a non‐centrosymmetric structure is reported. The lanthanide coordination polymer is composed of luminescent EuIII ions and bidentate phosphane oxides, poly[3,3′‐bis(diphenylphosphoryl)‐2,2′‐bipyridine][tris(hexafluoroacetylacetonate)]europium (poly‐Eu‐BIPYPO) crystals. The coordination geometry of poly‐Eu‐BIPYPO is categorized as an asymmetric eight‐coordinate square antiprism (8‐SAP). The space group of the crystal is also classified as the non‐centrosymmetric Cc, which is suitable for piezoelectricity and triboluminescence. The photoluminescence quantum yield of poly‐Eu‐BIPYPO crystals excited at 380 nm is found to be 61 %. Triboluminescence of the lanthanide coordination polymer is observed upon breaking, even at ambient temperature and in daylight. The remarkable triboluminescence phenomenon and geometrical structure of lanthanide coordination polymer are demonstrated.
Synthesis and Structures of Fluoroalkylated Triketides
Authors: Büttner Stefan , Desens Willi , Michalik Dirk , Langer Peter 
Published: October 2011

AbstractThe synthesis and structures of fluoroalkylated triketides (3,5‐dioxo esters) and 1,3,5‐triketones – such as 1,1,1‐trifluoroheptane‐2,4,6‐dione – were studied. The synthesis is based on reactions between 1,3‐dicarbonyl dianions and esters. In CDCl3, the fluoroalkylated triketides exclusively exist in the forms of enol tautomers. In [D6]DMSO, equilibria between enols and keto hydrates, formed by addition of water to the enols, are observed. In [D6]DMSO, 1,1,1‐trifluoroheptane‐2,4,6‐dione and 5‐chloro‐1,1,1‐trifluoroheptane‐2,4,6‐dione exist exclusively in the forms of their cyclic hemiketals. In CDCl3, tautomeric mixtures of the hemiketals and of three open‐chained tautomers are observed (among which the dienol tautomers are predominant).
Uncertainties of Yeast‐Based Biofuel Cell Operational Characteristics
Authors: Babanova S. , Hubenova Y. , Mitov M. , Mandjukov P. 
Published: October 2011

AbstractThe commonly used parameters characterizing fuel cells and in particular microbial fuel cells (MFCs) electrical performance are open circuit voltage (OCV), maximum power, and short circuit current. These characteristics are usually obtained from polarization and power curves. In the present study, the expanded uncertainties of operational characteristics for yeast‐based fuel cell were evaluated and the main sources of uncertainty were determined. Two approaches were used: the uncertainty budget building for sources uncertainty estimation and a statistical treatment of identical MFCs results – for operational characteristics uncertainty calculation. It was found that in this particular bioelectrochemical system the major factor contributing to operational characteristics uncertainties was the electrodes' resistance. The operational characteristics uncertainties were decreased from 19 to 13% for OCV, from 42 to 14% for maximal power, and from 46 to 13% for short circuit current with the usage of electrodes with resistance in the interval 6–7 Ω. The described approaches can be used for operational characteristics expanded uncertainties calculation of all types of fuel cells using data from polarization measurements.
Geotechnical monitoring as key safety management element at the Dürnstein/Wachau rockslide / Geotechnische Messungen als zentraler Bestandteil des Sicherheitsmanagementplans beim Felssturz Dürnstein/Wachau
Authors: Müllegger Martin , Lenz Gerold , Laimer Hans Jörg 
Published: October 2011

AbstractFollowing a rockslide in a former quarry near the town of Dürnstein/Wachau, extensive remedial measures were necessary to restore the damaged rail infrastructure and ensure long term safety. To provide for safe working conditions during the phase of construction of additional protection measures, a geotechnical risk management system based on the observational method per EC 7 was developed and implemented. Geotechnical monitoring was a key safety management element. The paper discusses the specific challenges, practical approaches and general experiences associated with the use of the observational method for the monitoring of cliff faces.Nach einem Felssturz in einem ehemaligen Steinbruchgelände nahe der Ortschaft Dürnstein/ Wachau waren umfangreiche Maßnahmen zur Wiederherstellung und langfristigen Sicherung der stark beschädigten Bahnlinie erforderlich. Um während der Sanierungsphase die Sicherheit gewährleisten zu können, wurde ein Risikomanagement in Anlehnung an die Beobachtungsmethode nach EC 7 geplant und umgesetzt. Zentraler Bestandteil des Sicherheitsmanagementplans waren geotechnische Messungen.Der vorliegende Beitrag berichtet über die speziellen Herausforderungen, konkreten Problemlösungsansätze und allgemeinen Erfahrungen bei der Anwendung der Beobachtungsmethode zur Überwachung von Felswänden.
TBM advance in the main adit to the Nant de Drance pumped storage power plant / TBM Vortrieb im Hauptzugangstunnel zum Pumpspeicherkraftwerk Nant de Drance
Authors: Weh Markus , Bertholet Francois 
Published: October 2011

AbstractThe 5.6 km long main adit of the pumped storage power plant at Nant de Drance in Switzerland is currently under construction. The tunnel is being excavated by a hard rock TBM with a diameter of 9.45 m. Unexpectedly high water inflows with water pressures up to 42 bar as well as unfavourable ground conditions have caused various delays and interruptions of the excavation. To overcome the unfavourable ground conditions, grouting works are facilitated ahead of the TBM as well as from the backup. The paper describes the design and implementation of the grouting works on site as well as the effect of the encountered rock mass conditions on the TBM advance with a special focus on the influence of unstable face conditions, blocky ground and high water pressure.Im Pumpspeicherprojekt Nant de Drance in der Schweiz wird der 5,6 km lange Zugangsstollen (Durchmesser 9,45 m) mittels einer Gripper‐Hartgesteins‐TBM aufgefahren. Aufgrund von hohen Bergwasserzutritten mit Wasserdrücken bis 42 bar und aufgrund von schleifenden Störzonen mit schlechten Gebirgsbedingungen musste das Gebirge mittels acht Injektionsbohrschirmen entweder abgedichtet oder konsolidiert werden. Der Artikel erläutert, wie diese Maßnahmen ursprünglich geplant und nachher auch umgesetzt wurden. Zudem wird aufgezeigt, wie die angetroffenen Bedingungen den TBM‐Vortrieb beeinflussten. Im speziellen wird auf instabile Ortsbrustbedingungen, blockiges Ausbruchmaterial und hohe Bergwasserdrücke beim TBM‐Vortrieb oder bei der Ausführung von Bohrungen eingegangen.