bluuebunny/crossref_metadata_2025_split huggingface dataset:
2009 Influenza A (H1N1) in Panama: a disease affecting children with a benign course
Authors: Nieto- Guevara Javier , Sosa Nestor , Garcia Mariana , Martinez Alex , Castillo Marlene 
Published: September 2011

Introduction: Pandemic Influenza A (H1N1) was identified as the major febrile respiratory illness worldwide during the year 2009. We present a report of its clinical and epidemiological characteristics in children and adults in Panama. Methodology: A descriptive study from the database of the Gorgas Memorial Institute is presented. We included patients with severe acute respiratory infection in whom a nasopharyngeal swab was positive by real-time RT-PCR for 2009 Influenza A (H1N1) pandemic virus and negative for seasonal influenza A H1 and H3. Results: From 26 April 2009 to 11 January 2010, confirmed cases of pandemic 2009 Influenza A (H1N1) reached 806. The overall incident rate was 23.35 cases of pandemic influenza per 100,000 habitants, with the highest incidence found in the age group between 10 to 14 years of age (58.67 cases per 100,000 habitants). The median age for the cases was 13 years (ages ranging from one day to 88 years) and 71% were from the Panama City Metropolitan Area. The male/female ratio was 1:1 and 90% were managed as out-patients. An influenza-like syndrome was the presenting diagnosis in 99% of the cases. Fever and cough were the most frequent symptoms reported in all age groups. The case fatality rate was 0.3 cases per 100,000 habitants. Conclusion: The 2009 Influenza A (H1N1) outbreak affected mainly the pediatric population, had a low case fatality rate, and was the predominant virus circulating in Panama during the 2009/2010 flu season
La « North Limit Line » en mer Jaune et le retour de la guerre froide sur la péninsule coréenne
Authors: Yoo Junghwan 
Published: September 2011

Au-delà de l’indignation et de la surprise, suite au bombardement de l’île sud-coréenne de Yeonpyeong, perpétré par l’armée nord-coréenne en novembre 2010, on essaie ici de récapituler les incidents militaires entre les deux Corées autour de la NLL ( North Limit Line ), une ligne de démarcation maritime en mer Jaune. Cet acte d’agression directe du sol et de la population impliquant le retour sur la péninsule coréenne de la guerre froide, on réfléchit sur les effets des politiques nord-coréennes de Séoul sur la relation intercoréenne. Car, à l’égard du régime nord-coréen toujours menaçant et provocateur, les gouvernements libéraux ont mené la politique de rapprochement tandis que le gouvernement conservateur actuel poursuit la politique de pression. Si les gouvernements libéraux se sont occupés d’abord du problème de paix sur la péninsule, le gouvernement conservateur s’efforce, avec le gouvernement Obama, d’obtenir la dénucléarisation et/ou le « regime change » de la Corée du Nord. Et pour trancher entre les deux, on attend le verdict populaire, au rendez-vous en 2012, année des élections générales et présidentielle.
L'économie politique coréenne, d'une crise à l'autre
Authors: Cho Hong-Sik 
Published: September 2011

Cet article se propose d’analyser l’évolution de l’économie politique coréenne de la crise asiatique de 1997 jusqu’à la période récente dans la vague de la crise mondiale de 2008. La Corée a vu se succéder trois gouvernements qui se sont caractérisés, d’abord par une libéralisation générale de l’économie sous les deux gouvernements de gauche dans un effort pour surmonter la première crise, et ensuite par un retour du rôle de l’État dans le développement économique sous le gouvernement de droite dans le cadre de la gestion de la seconde crise. Dans le même temps, la Corée semble affirmer son rôle de leader mondial dans des secteurs comme l’électronique, l’informatique ou la construction navale. Mais malgré ces succès, il est tout aussi évident qu’elle présente des faiblesses à long terme tant sur le plan démographique que sur le plan social. Enfin, la Corée se trouve dans une situation délicate où elle doit gérer ses relations traditionnelles privilégiées avec les États-Unis d’une part, et celles avec la Chine à l’hégémonie ascendante, d’autre part.
Polar français au cinéma (1961-2011)
Authors: Poirson-Dechonne Marion 
Published: September 2011

Résumé Le cinéma policier français prend dès les années 1930 une dimension politique, que renforcera l’influence du film noir américain. Au cours des années 1960-1970, cet engagement se précise, devient militant. Que s’est-il passé des années 1980 à nos jours ? Cette tendance, encore présente dans le roman, persiste-t-elle au cinéma ?
Nos fantastiques années fric : une affaire d'État ?
Authors: Osganian Patricia , Perriaux Anne-Sophie , Flory Julienne 
Published: September 2011

Résumé Longtemps enseignante en Histoire et syndicaliste, Dominique Manotti est aujourd’hui l’une des figures incontournables du néopolar français. Ses romans racontent, sur fond de luttes sociales, la corruption des gouvernements et les conséquences humaines désastreuses du capitalisme. Son dernier roman, L’Honorable Société , coécrit avec DOA, est paru chez Gallimard en 2011. Mouvements s’est tout particulièrement intéressé à Nos fantastiques années fric (Rivages, 2001), qui livre le récit des compromissions de masse du mitterrandisme : trafic d’armes, affaire des otages du Liban, scandale des écoutes téléphoniques, conversion de la gauche au pouvoir de l’argent. Adapté au cinéma par Éric Valette sous le titre Une affaire d’État (sorti en 2009), ce roman nous a donné l’occasion de revenir, avec l’auteur, puis le réalisateur auquel on doit récemment La Proie (avril 2011), sur les enjeux du passage du livre à l’écran.
Laura, saison II
Authors: Vix Élisa 
Published: September 2011

Résumé Auteure de romans policiers, Élisa Vix a reçu le prix du meilleur polar francophone 2007 de Montigny-lès-Cormeilles pour Bad Dog (éditions Odin, 2006) où elle met en scène, pour la seconde fois, le lieutenant Sauvage, personnage gentiment incorrect, macho pathétique et policier hérétique, auquel elle n’a fait qu’une concession : son amour pour le cinéma. Bad Dog et La baba-yaga (Odin, 2005) sont adaptés pour la télévision dans la série Tango de France 2. Elle a conçu pour Mouvements , à l’occasion de ce numéro dédié au polar à l’écran, une nouvelle entièrement originale.
2011 : le printemps arabe ?
Authors: Amin Samir 
Published: September 2011

Résumé L’année 2011 s’est ouverte par une série d’explosions fracassantes de colère des peuples arabes. Ce printemps arabe amorcera-t-il un second temps de « l’éveil du monde arabe » ? Ou bien ces révoltes vont-elles piétiner et finalement avorter – comme cela a été le cas du premier moment de cet éveil évoqué dans mon livre L’éveil du Sud . Dans la première hypothèse, les avancées du monde arabe s’inscriront nécessairement dans le mouvement de dépassement du capitalisme/impérialisme à l’échelle mondiale. L’échec maintiendrait le monde arabe dans son statut actuel de périphérie dominée, lui interdisant de s’ériger au rang d’acteur actif dans le façonnement du monde.
A Novel Antireflux Technique for Orthotopic Ileal Bladder Substitutes—Flat-Segment Technique: Preliminary Results
Authors: ElFayoumy Hany , Abou-Elela Ashraf , Orban Tamer , Emran Ashraf , Elghoneimy Mohamed , Morsy Ahmed 
Published: September 2011

Objective. Although a large debate exists regarding the need for reflux prevention in ileal orthotopic neobladders, it is our policy to continue performing nonrefluxing ureteroileal anastomoses for our patients. An ideal uretero-ileal anastomosis must be simple, nonrefluxing, as well as non-obstructive. Here, we	present a new antireflux mechanism for orthotopic ileal neobladders. Methods. 12 radical cystectomy patients for muscle invasive bladder cancer were candidates for orthotopic urinary diversion and underwent a non-refluxing uretero-ileal anastomosis	using the flat-segment technique with a follow up of 6 to 18 months. Results. Preliminary results after the short-term followup showed that the success rate in reflux prevention was 92% and no cases of obstruction. The upper tracts were preserved or improved in all 12 patients. Operative time for neobladder creation ranged between 120–240 minutes, with a mean of 165 minutes (±36 minutes). No diversion-related complications. Conclusions. Based on our early data, we believe that the flat-segment uretero-ileal anastomosis technique for reflux prevention in orthotopic ileal bladder substitutes is simple, easy to learn and carries no additional morbidity to a standard refluxing uretero-ileal anastomosis, but has the advantage of effective reflux prevention. A longer follow-up period study with more patient numbers is ongoing.
Current and future needs for developmental toxicity testing
Authors: Makris Susan L. , Kim James H. , Ellis Amy , Faber Willem , Harrouk Wafa , Lewis Joseph M. , Paule Merle G. , Seed Jennifer , Tassinari Melissa , Tyl Rochelle 
Published: September 2011

AbstractA review is presented of the use of developmental toxicity testing in the United States and international regulatory assessment of human health risks associated with exposures to pharmaceuticals (human and veterinary), chemicals (agricultural, industrial, and environmental), food additives, cosmetics, and consumer products. Developmental toxicology data are used for prioritization and screening of pharmaceuticals and chemicals, for evaluating and labeling of pharmaceuticals, and for characterizing hazards and risk of exposures to industrial and environmental chemicals. The in vivo study designs utilized in hazard characterization and dose‐response assessment for developmental outcomes have not changed substantially over the past 30 years and have served the process well. Now there are opportunities to incorporate new technologies and approaches to testing into the existing assessment paradigm, or to apply innovative approaches to various aspects of risk assessment. Developmental toxicology testing can be enhanced by the refinement or replacement of traditional in vivo protocols, including through the use of in vitro assays, studies conducted in alternative nonmammalian species, the application of new technologies, and the use of in silico models. Potential benefits to the current regulatory process include the ability to screen large numbers of chemicals quickly, with the commitment of fewer resources than traditional toxicology studies, and to refine the risk assessment process through an enhanced understanding of the mechanisms of developmental toxicity and their relevance to potential human risk. As the testing paradigm evolves, the ability to use developmental toxicology data to meet diverse critical regulatory needs must be retained. Birth Defects Res (Part B) 92:384–394, 2011.© 2011 Wiley Periodicals, Inc.
Effects of in utero exposure to Bisphenol A or diethylstilbestrol on the adult male reproductive system
Authors: LaRocca Jessica , Boyajian Alanna , Brown Caitlin , Smith Stuart Duncan , Hixon Mary 
Published: September 2011

AbstractThe objective of this study was to determine whether in utero exposure to Bisphenol A (BPA) induced reproductive tract abnormalities in the adult male testis. Using the C57/Bl6 mouse, we examined sex‐organ weights, anogenital distance, and testis histopathology in adult males exposed in utero via oral gavage to sesame oil, 50 µg/kg BPA, 1000 µg/kg BPA, or 2 µg/kg diethylstilbestrol (DES) as a positive control from gestational days 10 to 16. No changes in sperm production or germ cell apoptosis were observed in adult testes after exposure to either chemical. Adult mRNA levels of genes associated with sexual maturation and differentiation, GATA4 and ID2, were significantly lower only in DES‐exposed testes. In summary, the data indicate no gross alterations in spermatogenesis after in utero exposure to BPA or DES. At the molecular level, in utero exposure to DES, but not BPA, leads to decreased mRNA expression of genes associated with Sertoli cell differentiation. Birth Defects Res (Part B) 92:526–533, 2011. © 2011 Wiley Periodicals, Inc.
From Waste Air Treatment to Resource Efficiency
Authors: Thißen Nikolaus , Loock Jan van 
Published: September 2011

AbstractEine Anlage zur Reinigung der Abluft eines chemischen Produktionsprozesses verursacht hohe Kosten durch technische Probleme während des Betriebs. Der Beitrag beschreibt die Vorgehensweise, wie durch systematische Analyse und Verbesserung eine Strategie erarbeitet wird, die den Betrieb der Anlage zur Abluftreinigung erübrigt. Als positiver Effekt auf die Ressourceneffizienz wird der Schadstoff halogenierter Kohlenwasserstoff im betrachteten Kreislauf vollständig als Wertstoff in den Produktionsprozess zurückgeführt sowie der Verbrauch an Betriebsmitteln und damit deren Kosten drastisch reduziert; der Prozess wird an dieser Stelle emissionsfrei.
Investigating the use of an adjustment task to set preferred colour of ambient illumination
Authors: Logadóttir Ásta , Fotios Steve A. , Christoffersen Jens , Hansen Soren S. , Corell Dennis D. , Dam‐Hansen Carsten 
Published: September 2011

AbstractAn experiment was carried out to examine the method of adjustment when determining user preferences for the colour appearance of ambient lighting. A booth was lit using luminaires containing an array of white and coloured light emitting diodes (LEDs), allowing continuous variation of correlated colour temperature (CCT) between 2736 and 4014 K. It was predicted that the preferred CCT would be influenced by the available stimulus range, the anchor (initial setting before adjustment), adaptation time before onset of adjustment action and type of control dial. Preference was estimated for three different CCT stimulus ranges within the available range. All three ranges led to significantly different results for preferred CCT: 3288, 3490 and 3671 K. The experimental results confirmed that stimulus range, anchor and adaptation time have significant effect on the preferred CCT determined using the adjustment task, and thus, the importance of considering and reporting this information in studies that employ the method of adjustment. © 2011 Wiley Periodicals, Inc. Col Res Appl, 2013
Decorating the Second Coordination Sphere in Pyrazolate‐Based Dinickel(II) Complexes with H‐Bond Donors (Eur. J. Inorg. Chem. 27/2011)
Authors: Graef Tine , Galezowska Joanna , Dechert Sebastian , Meyer Franc 
Published: September 2011

AbstractThe cover picture shows (i) a Helicobacter pylori that produces large amounts of the enzyme urease to survive in the acidic human stomach, (ii) the urease active site, and (iii) a bioinspired bimetallic complex that features second‐shell hydrogen bonding akin to the situation in the metalloenzyme. The article by F. Meyer et al. on p. 4161 ff reports the synthesis of an elaborate new ligand scaffold that is decorated with peripheral groups for H‐bonding interactions and its speciation with nickel(II) in solution. The crystallographic structure of a dinickel(II) complex reveals a bridging HO···H···OH unit in the bimetallic cavity, which is involved in an extensive network of hydrogen bonds. Such systems might become useful for studying effects of the secondary coordination sphere in biomimetic substrate transformations.
Three‐Component Domino Knoevenagel/Hetero‐Diels–Alder Reaction for the Synthesis of the Amino Sugars 2‐Acetoxyforosamine and 2‐Acetoxyossamine – Experimental and Theoretical Results
Authors: Tietze Lutz F. , Dietz Simone , Böhnke Niels , Düfert M. Alexander , Objartel Ina , Stalke Dietmar 
Published: September 2011

AbstractThe three‐component domino Knoevenagel/hetero‐Diels–Alder reaction of nitroacetone (6), formaldehyde and ethoxyvinylacetate (4) leads to dihydropyrans 10 and 11, which after hydrogenation of the double bond as well as consecutive reduction of the nitro group and reductive amination give the desired forosamine‐type 2‐acetoxyamino sugars 21–24 and ossamine‐type 25.
Mitochondrial DNA copy number and hnRNP A2/B1 protein: Biomarkers for direct exposure of benzene
Authors: Eom Ha-Young , Kim Hye-Ran , Kim Hwan-Young , Han Dong-Kyun , Baek Hee-Jo , Lee Jae-Hyuk , Moon Jai Dong , Shin Jong-Hee , Suh Soon-Pal , Ryang Dong-Wook , Kook Hoon , Shin Myung-Geun 
Published: September 2011

Abstract
The present study was performed to identify biomarkers for exposure of benzene in blood cells and hematopoietic tissues. Peripheral mononuclear cells, hematopoietic stem cells, and leukemia cell lines were cultured in RPMI 1640 media with the addition of 0, 1, and 10 mM of benzene. Hydrogen peroxide was measured using an enzyme immunoassay. Mitochondrial mass, membrane potential, and mitochondrial DNA (mtDNA) copy number were measured using MitoTracker Green/Red probes, and real-time polymerase chain reaction. In addition, two-dimensional gel electrophoresis and mass spectrometry matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) technology were performed to identify protein markers. The mitochondrial contents and membrane potentials were dramatically increased after three weeks of direct benzene exposure. The hydrogen peroxide level increased significantly after two weeks of treatment with benzene (4.4 ± 1.9 µM/mg protein) compared to the non-benzene treatment group (1.2 ± 1.0; p = 0.001). The mtDNA copy number gradually increased after exposure to benzene. Numerous protein markers showed significant aberrant expression after exposure to benzene. Among them, the heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 was markedly decreased after exposure to benzene. Thus, increased mitochondrial mass, mtDNA copy number, and the hnRNP A2/B1 protein were biomarkers for benzene-related toxicity and hematotoxicity. Environ. Toxicol. Chem. 2011;30:2762–2770. © 2011 SETAC
Multilocus association testing with penalized regression
Authors: Basu Saonli , Pan Wei , Shen Xiaotong , Oetting William S. 
Published: September 2011

AbstractIn multilocus association analysis, since some markers may not be associated with a trait, it seems attractive to use penalized regression with the capability of automatic variable selection. On the other hand, in spite of a rapidly growing body of literature on penalized regression, most focus on variable selection and outcome prediction, for which penalized methods are generally more effective than their nonpenalized counterparts. However, for statistical inference, i.e. hypothesis testing and interval estimation, it is less clear how penalized methods would perform, or even how to best apply them, largely due to lack of studies on this topic. In our motivating data for a cohort of kidney transplant recipients, it is of primary interest to assess whether a group of genetic variants are associated with a binary clinical outcome, acute rejection at 6 months. In this article, we study some technical issues and alternative implementations of hypothesis testing in Lasso penalized logistic regression, and compare their performance with each other and with several existing global tests, some of which are specifically designed as variance component tests for high‐dimensional data. The most interesting, and perhaps surprising, conclusion of this study is that, for low to moderately high‐dimensional data, statistical tests based on Lasso penalized regression are not necessarily more powerful than some existing global tests. In addition, in penalized regression, rather than building a test based on a single selected “best” model, combining multiple tests, each of which is built on a candidate model, might be more promising. Genet. Epidemiol. 2011.© 2011 Wiley Periodicals, Inc. 35:755‐765, 2011
Defining the power limits of genome‐wide association scan meta‐analyses
Authors: Chapman Kay , Ferreira Teresa , Morris Andrew , Asimit Jennifer , Zeggini Eleftheria 
Published: September 2011

AbstractLarge‐scale meta‐analyses of genome‐wide association scans (GWAS) have been successful in discovering common risk variants with modest and small effects. The detection of lower frequency signals will undoubtedly require concerted efforts of at least similar scale. We investigate the sample size‐dictated power limits of GWAS meta‐analyses, in the presence and absence of modest levels of heterogeneity and across a range of different allelic architectures. We find that data combination through large‐scale collaboration is vital in the quest for complex trait susceptibility loci, but that effect size heterogeneity across meta‐analyzed studies drawn from similar populations does not appear to have a profound effect on sample size requirements. Genet. Epidemiol. 2011. © 2011 Wiley Periodicals, Inc. 35:781‐789, 2011
Studies on pyrazine derivatives LII: Antibacterial and antifungal activity of nitrogen heterocyclic compounds obtained by pyrazinamidrazone usage
Authors: Foks Henryk , Balewski Lukasz , Gobis Katarzyna , Dabrowska‐Szponar Maria , Wisniewska Katarzyna 
Published: September 2011

AbstractUsing reactivity of pyrazinamidrazones and their N′‐substituted derivatives 1–8 in reaction with sulfonyl chlorides sulfone derivatives 9–17 were obtained, with orthoformate cyclized to sulfonyl compounds 18–20. Amidrazones in reaction with pyraziniminoesters gave dihydrazidines 21–23, which cyclized to 3,5‐dipyrazine derivatives of 1,2,4‐triazole 24–26. 1‐Methyl‐ or 1‐phenyl‐3‐pyrazine‐1,2,4‐triazole 27–38 was formed in reaction of amidrazones 1–8 with orthoformate and orthoacetate or benzoyl chloride. N′‐Phenylamidrazones 3, 8 in reaction with thionyl chloride were transformed to 1,2,3,5‐thiatriazole S‐oxides 39, 40. Obtained compounds exhibited low antibacterial activity. Antifungal activity was affirmed for compounds 1, 3, 4, 5, 8, 37, 39, and 40, for which minimal inhibitory concentration (MIC) was in the concentration range of 16–128 μg/mL. © 2011 Wiley Periodicals, Inc. Heteroatom Chem 23:49–58, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.20751
Inclusion Complexes of Coenzyme Q10 with Polyamine‐Modified β‐Cyclodextrins: Characterization, Solubilization, and Inclusion Mode
Authors: Gu Juan , Chi Shao‐Ming , Zhao Yong , Zheng Ping , Ruan Qiong , Zhao Yan , Zhu Hong‐You 
Published: September 2011

AbstractThe inclusion‐complexation behavior of coenzyme Q10 (CoQ10) with the three polyamine‐modified β‐cyclodextrins (CDs) 1–3 was investigated in both solution and the solid state by means of NMR, XRD, and FT‐IR spectroscopy. The results showed that the apparent solubility of CoQ10 increased linearly upon addition of hosts 1–3, giving AL‐type phase‐solubility curves. These hosts 1–3 were able to solubilize CoQ10 to high levels, up to 1.35, 1.52, and 1.44 mg/ml (calculated as CoQ10), respectively. The host 2 with a moderate‐length chain is the most suitable for inclusion complexation of CoQ10. Accroding to the ROESY experiments, the MeO groups of CoQ10 and the tether of 2 can be co‐included into the cavity of β‐CD through the induced‐fit interaction between host and guest. The binding ability of modified β‐CDs 1–3 upon complexation with CoQ10 are discussed from the viewpoints of the size/shape‐matching relationship and the induced‐fit concept between host CDs and guest CoQ10 molecule.