bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterns of Work and Retirement Among Pediatricians Aged ≥50 Years
Authors: Merline Alicia C. , Cull William L. , Mulvey Holly J. , Katcher Avrum L. 
Published: December 2009

OBJECTIVE: This study examined patterns of work and retirement among older pediatricians, including the determinants of part-time work and retirement, as well as extended participation in the pediatrician workforce.
METHODS: A mail survey regarding recent and expected workforce participation was distributed to American Academy of Pediatrics members who were aged ≥50 years. A total of 1158 (72%) responded, 1114 (70%) of whom were included in these analyses. Analyses examined levels of engagement in medicine, retirement plans, and differences between men and women and primary care pediatricians and pediatric subspecialists.
RESULTS: Providing or planning to provide patient care past age 65 was reported by 45% of the respondents. Engaging in part-time work was increasingly more common with age and may represent a step toward retirement for many. In this sample, women were more likely to work part-time (32% vs 18% of men) and less likely to work past age 65 (26% vs 57% of men). When compared with primary care pediatricians, pediatric subspecialists worked more hours per week (59 vs 53) but spent a smaller percentage of their time on patient care (63% vs 82%).
CONCLUSIONS: Part-time work and reduced work hours in anticipation of retirement are options that are used and desired by older pediatricians. Results of this study suggest that making provisions for gradual reduction in work hours or other forms of phasing out of the workforce could benefit the practice of pediatrics by extending the career length of the most experienced pediatricians.
Resective Pediatric Epilepsy Surgery in Lennox-Gastaut Syndrome
Authors: Lee Yun Jin , Kang Hoon-Chul , Lee Joon Soo , Kim Shin Hye , Kim Dong-Seok , Shim Kyu-Won , Lee Yun-Ho , Kim Tae Seung , Kim Heung Dong 
Published: December 2009

OBJECTIVE: The objective of this study was to evaluate the role of resective pediatric epilepsy surgery for Lennox-Gastaut syndrome (LGS).
METHODS: We analyzed clinical data of 27 children and adolescents who had LGS and underwent resective epilepsy surgery despite abundant (&gt;30% of preoperative interictal and/or ictal epileptiform discharges) generalized or generalized contralateral maximal and multiregional electroencephalogram abnormalities.
RESULTS: On high-resolution MRI, cerebral lesions were noted in 23 (85.2%) patients but not in 4 (14.8%) patients. The age of patients at the time of surgery was between 1.7 and 17.3 years (mean: 7.8 years). Surgeries were lobar or multilobar resection in 21 (77.8%) patients and hemispherotomy in 6 (22.2%). At a mean of 33.1 months' postoperative follow-up, 16 (59.3%) patients had no seizures and 4 (14.8%) had infrequent seizures. Of 4 patients without brain abnormalities found on MRI, 2 patients became seizure-free after resective surgery was performed on the basis of electrophysiologic studies and concordant results in other multimodal neuroimages. Malformation of cortical development was the most common pathology and was seen in 20 (74.1%) patients, but 2 (7.4% patients) did not show any abnormal pathology. Sixteen (72.7%) patients, including 14 who had no seizures and 2 who had infrequent seizures after surgery, showed an increase in developmental quotient. No clinical profile was significantly associated with postoperative seizure-free rate.
CONCLUSIONS: Resective epilepsy surgery should be considered for children with LGS, despite abundant generalized and multiregional electroencephalogram abnormalities.
Biological and Environmental Predictors of Behavioral Sequelae in Children Born Preterm
Authors: Conrad Amy L. , Richman Lynn , Lindgren Scott , Nopoulos Peg 
Published: December 2009

OBJECTIVE: By using behavioral outcome measures of children who were born preterm, we evaluated differences between children who were born at term and children who were born at extremely low (ELBW; &lt;1000 g) and very low birth weights (VLBW; 1000–1499 g) and assessed the relationship of birth weight, socioeconomic status, and cognitive ability to behavioral outcome.METHODS: We studied a total of 104 children (aged 7–16 years). Of these, 49 had a preterm birth (31 of ELBW and 18 of VLBW). The remaining 55 were healthy control subjects. Children were administered tests of cognitive ability. Parents and teachers completed behavioral assessments. Multivariate analyses of covariance assessed differences between children who were born at term and those who were born of ELBW and of VLBW on behavioral measures. Hierarchical linear regressions were used to assess relationships among biological (birth weight), environmental (socioeconomic status), intellectual, and behavioral variables.RESULTS: Children who were born at term had fewer parent reports of hyperactivity/inattention and depression/anxiety symptoms than children of ELBW and VLBW. Teacher ratings were not significant between groups. Birth weight was consistently the strongest predictor of parent ratings of behavioral outcome, and intelligence level did not seem to mediate this relationship.CONCLUSIONS: Negative behavioral sequelae of preterm birth remain significant in middle childhood and adolescence, although the contribution of multiple factors to neurobehavioral outcome is complex. Research to assess these relationships, integrated with anatomic and functional neuroimaging, is needed to advance knowledge and improve outcomes for children who are born preterm.
Evaluation of Aortic Stiffness (Aortic Pulse–Wave Velocity) Before and After Elective Abdominal Aortic Aneurysm Repair Procedures: A Pilot Study#
Authors: Paraskevas Kosmas I , Bessias Nikolaos , Psathas Chrysovalantis , Akridas Konstantinos , Dragios Theodoros , Nikitas Georgios , Andrikopoulos Vassilios , Mikhailidis Dimitri P , Kyriakides Zenon S 
Published: December 2009

Background:
The main clinical criterion for abdominal aortic aneurysm (AAA) repair operations is an AAA diameter ≥5.5 cm. When AAAs increase in size, specific changes occur in the mechanical properties of the aortic wall. Pulse-wave velocity (PWV) has been used as an indicator of vascular stiffness. A low PWV may predict AAA rupture risk and is an early predictor of cardiovascular mortality.

Methods:
We investigated the prognostic value of PWV before and after elective AAA repair procedures. Twenty four patients scheduled for an open AAA repair underwent a preoperative carotid-femoral aortic PWV measurement. A second aortic PWV measurement was carried out 6 months postoperatively.

Results:
The mean aortic PWV increased from 7.84 ± 1.85 preoperatively to 10.08 ± 1.57 m/sec 6 months postoperatively (mean change: 2.25; 95% confidence interval 1.4 to 3.1 m/sec; p<0.0001). The preprocedural PWV measurement did not correlate with AAA diameter (Spearman’s rank correlation coefficient ρ=0.12; p=0.59).

Conclusions:
Whether the increase in aortic PWV postoperatively suggests a decreased cardiovascular risk following AAA repair remains to be established. Aortic PWV should also be investigated as an adjunct tool for assessing AAA rupture risk.
Pregabalin as an adjunct to phenobarbital, potassium bromide, or a combination of phenobarbital and potassium bromide for treatment of dogs with suspected idiopathic epilepsy
Authors: Dewey Curtis W. , Cerda-Gonzalez Sofia , Levine Jonathan M. , Badgley Britton L. , Ducoté Julie M. , Silver Gena M. , Cooper Jocelyn J. , Packer Rebecca A. , Lavely James A. 
Published: December 2009

Abstract
Objective—To assess tolerability and short-term efficacy of oral administration of pregabalin as an adjunct to phenobarbital, potassium bromide, or a combination of phenobarbital and potassium bromide for treatment of dogs with poorly controlled suspected idiopathic epilepsy.
Design—Open-label, noncomparative clinical trial.
Animals—11 client-owned dogs suspected of having idiopathic epilepsy that was inadequately controlled with phenobarbital, potassium bromide, or a combination of these 2 drugs.
Procedures—Dogs were treated with pregabalin (3 to 4 mg/kg [1.4 to 1.8 mg/lb], PO, q 8 h) for 3 months. Number of generalized seizures in the 3 months before and after initiation of pregabalin treatment was recorded. Number of responders (≥ 50% reduction in seizure frequency) was recorded, and seizure frequency before and after initiation of pregabalin treatment was compared by use of a nonparametric Wilcoxon signed rank test.
Results—Seizures were significantly reduced (mean, 57%; median, 50%) after pregabalin administration in the 9 dogs that completed the study; 7 were considered responders with mean and median seizure reductions of 64% and 58%, respectively. Adverse effects for pregabalin were reported in 10 dogs. Mean and median plasma pregabalin concentrations for all dogs were 6.4 and 7.3 μg/mL, respectively.
Conclusions and Clinical Relevance—Pregabalin may hold promise as a safe and effective adjunct anticonvulsant drug for epileptic dogs poorly controlled with the standard drugs phenobarbital or potassium bromide. Adverse effects of pregabalin appeared to be mild. Additional studies with larger numbers of dogs and longer follow-up intervals are warranted.
Silicate-carbonate-salt liquid immiscibility and origin of the sodalite-haüyne rocks: study of melt inclusions in olivine foidite from Vulture volcano, S. Italy
Authors: Panina Liya , Stoppa Francesco 
Published: December 2009

Abstract
Melt inclusions in clinopyroxenes of olivine foidite bombs from Serra di Constantinopoli pyroclastic flows of the Vulture volcano (Southern Italy) were studied in detail. The rocks contain abundant zoned phenocrysts and xenocrysts of clinopyroxene, scarce grains of olivine, leucite, haüyne, glass with microlites of plagioclase and K-feldspar. The composition of clinopyroxene in xenocrysts (Cpx I), cores (Cpx II), and in rims (Cpx III) of phenocrysts differs in the content of Mg, Fe, Ti, and Al. All clinopyroxenes contain two types of primary inclusion-pure silicate and of silicate-carbonate-salt composition. This fact suggests that the phenomena of silicate-carbonate immiscibility took place prior to crystallization of clinopyroxene. Homogenization of pure silicate inclusions proceeded at 1 225 – 1 190°C. The composition of conserved melts corresponded to that of olivine foidite in Cpx I, to tephrite-phonolite in Cpx II, and phonolite-nepheline trachyte in Cpx III. The amount of water in them was no more than 0.9 wt.%. Silicate-carbonate inclusions decrepitated on heating. Salt globules contained salts of alkali-sulphate, alkali-carbonate, and Ca-carbonate composition somewhat enriched in Ba and Sr. This composition is typical of carbonatite melts when decomposed into immiscible fractions. The formation of sodalite-haüyne rocks from Vulture is related to the presence of carbonate-salt melts in magma chamber. The melts conserved in clinopyroxenes were enriched in incompatible elements, especially in Cpx III. High ratios of La, Nb, and Ta in melts on crystallization of Cpx I and Cpx II suggest the influence of a carbonatite melt as carbonatites have extremely high La/Nb and Nb/Ta and this is confirmed by the appearance of carbonatite melts in magma chamber. Some anomalies in the concentrations and relatives values of Eu and especially Ga seems typical of Italian carbonatite related melts. The mantle source for initial melts was, most likely, rather uniform, undepleted and was characterized by a low degree of melting and probable presence of garnet in restite.
The Inhibitor of Cyclin-Dependent Kinases, Olomoucine II, Exhibits Potent Antiviral Properties
Authors: Holcakova Jitka , Tomasec Peter , Bugert Joachim J , Wang Eddie CY , Wilkinson Gavin WG , Hrstka Roman , Krystof Vladimir , Strnad Miroslav , Vojtesek Borivoj 
Published: December 2009

Background:Olomoucine II, the most recent derivative of roscovitine, is an exceptionally potent pharmacological inhibitor of cyclin-dependent kinase activities. Here, we report that olomoucine II is also an effective antiviral agent.Methods:Antiviral activities of olomoucine II were tested on a range of human viruses in in vitro assays that evaluated viral growth and replication.Results:Olomoucine II inhibited replication of a broad range of wild-type human viruses, including herpes simplex virus, human adenovirus type-4 and human cytomegalovirus. Olomoucine II also inhibited replication of vaccinia virus and herpes simplex virus mutants resistant to conventional acyclovir treatment. This report is the first demonstration of a poxvirus being sensitive to a cyclin-dependent kinase inhibitor. The antiviral effects of olomoucine II could be observed at lower concentrations than with roscovitine, although both were short-term. A remarkable observation was that olomoucine II, when used in combination with the DNA polymerase inhibitor cidofovir, was able to almost completely eliminate the spread of infectious adenovirus type-4 progeny from infected cells.Conclusions:Our results show that when targeting two complementary antiviral mechanisms, strongly additive effects could be observed.
Wavefront-Guided Photorefractive Keratectomy to Correct Ametropia Following Aspheric ReSTOR Implantation
Authors: Kuo Irene C. , Myrowitz Elliott , Chuck Roy S. , Schein Oliver D. 
Published: December 2009

Purpose:
To describe the clinical course of three eyes of two patients who underwent wavefront-guided photorefractive keratectomy to correct ametropia following cataract extraction and aspheric ReSTOR lens (SN6AD3; +4.00-diopter model) implantation.

Methods:
Pre- and postoperative uncorrected visual acuity (UCVA) and best spectacle-corrected visual acuity (BSCVA), manifest refraction, and WaveScans based on the Hartmann-Shack analyzer were evaluated. The VISX STAR S4 excimer with eye tracking and iris registration was used in all cases.

Results:
Good quality WaveScans were obtained; UCVA improved in all cases and BSCVA improved or remained unchanged.

Conclusions:
These cases demonstrate that it is possible to obtain good quality wavefront data in patients with the ReSTOR lens and to use such data to design wavefront-guided treatment to maximize uncorrected distance and near visual acuities after ReSTOR implantation.

[
J Refract Surg
. 2009;25:1111–1115.]
Outcomes of the AcrySof ReSTOR IOL in Myopes, Emmetropes, and Hyperopes
Authors: Petermeier Katrin , Messias Andre , Gekeler Florian , Spitzer Martin S. , Szurman Peter 
Published: December 2009

Purpose:
To evaluate the influence of preoperative ocular parameters on various parameters of postoperative outcome after implantation of the AcrySof ReSTOR intraocular lens (IOL) in myopic, hyperopic, and emmetropic patients.

Methods:
Phacoemulsification and IOL implantation was performed in 56 eyes of 32 patients. According to axial length, 28 eyes were classified as emmetropic, 16 as myopic, and 12 as hyperopic. Patients were examined after 8.2±1.8 months (range: 5.7 to 10.5 months) for uncorrected and best distance-corrected visual acuity for far, intermediate, and near vision. A defocus profile was recorded and individual reading distance and distance for lowest intermediate visual acuity were determined. The predictability of three different calculation formulas was evaluated. Patients were interviewed for photic phenomena, quality of night vision, spectacle independence, and satisfaction with visual outcome.

Results:

Predictability of IOL calculation was not statistically significant among groups using the SRK-T formula, but was significantly different with the Haigis (
P
=.01) or Holladay I (
P
=.02) formulas. Uncorrected and best distance-corrected visual acuity for near, intermediate, and far vision were not significantly different among groups. Mean uncorrected far visual acuity was 20/23±5.5 letters, 20/25±6 letters, and 20/25±4.5 letters and uncorrected near visual acuity was 20/25±5.5 letters, 20/26±4.5 letters, and 20/26±7.5 letters for the emmetropic, myopic, and hyperopic groups, respectively. The defocus profile significantly varied among groups; patients of the hyperopic group showed a closer reading distance (29.5 cm) than patients of the emmetropic (32.8 cm) and myopic (34.6 cm) groups. Reading distance was statistically significantly correlated to axial length and anterior chamber depth and thus can be estimated preoperatively.

Conclusions:
Our data show that preoperative refractive status is a relevant factor influencing postoperative outcome after implantation of a ReSTOR IOL. Predictability of IOL calculation and defocus profile were significantly different for myopic, emmetropic, and hyperopic patients.

[
J Refract Surg.
2009;25:1103–1109.]
OVIPOSITION AND SURVIVAL OF THREE NEARCTIC EUPHORINE BRACONIDS IN CRUCIFER-INFESTING FLEA BEETLES (COLEOPTERA: CHRYSOMELIDAE)
Authors: Wylie H. G. 
Published: December 2009

AbstractFemales ofMicroctonus vittataeMues.,Microctonus punctulataeLoan and Wylie, andTownesilitus psylliodisLoan oviposited and survived in only some of the species of crucifer-infesting flea beetles that they encounter on rapeseed.M. vittataeoviposited readily inPhyllotreta striolata(F.), less often inPhyllotreta cruciferae(Goeze) andPhyllotreta pusillaHorn, and rarely inPsylliodes punctulataMelsh.; the progeny matured inP. striolata,P. cruciferae, andP. pusilla. M. punctulataeoviposited readily inP. punctulataandP. pusilla, occasionally inP. striolata, but never inP. cruciferae; the progeny matured only inP. punctulataandP. pusilla. Females ofT. psylliodisoviposited readily inP. punctulata, rarely inP. pusillaandP. striolata, but never inP. cruciferae; parasite progeny matured only inP. punctulata.
THE SUBLETHAL EFFECTS OF SELECTED INSECTICIDES ON LIFE TABLE PARAMETERS OF PANONYCHUS CITRI (ACARI: TETRANYCHIDAE)
Authors: Jones Vincent P. , Parrella Michael P. 
Published: December 2009

AbstractPopulations of the citrus red mite, Panonychus citri (McGregor), reared on “rough lemon” seedlings (Citrus limon (L.) Burm.) in a greenhouse and treated with malathion or permethrin were significantly higher than those on untreated seedlings. Significant increases were demonstrated in age-specific fecundity (mx), mortality corrected mx (lx mx), and net reproductive rate (Ro) values for mites reared in the laboratory on leaves treated with malathion or permethrin when compared with those reared on untreated leaves. Mites reared on oxamyl-treated leaves exhibited significant reductions in age-specific survivorship (% lx), mx, lxmx, and Ro values compared with those reared on untreated leaves. The importance of reproductive stimulation in relation to other causes of pest resurgence is discussed.
JOINT ACTION OF A JUVENILE HORMONE ANALOGUE WITH BENZOYLPHENYLUREAS INGESTED BY WESTERN SPRUCE BUDWORM, CHORISTONEURA OCCIDENTALIS (LEPIDOPTERA: TORTRICIDAE)
Authors: Robertson Jacqueline L. , Smith Kimberly C. , Granett Jeffrey , Retnakaran Arthur 
Published: December 2009

AbstractMixtures of the juvenile hormone analogue (JHA) methoprene and each of three benzoylphenylureas (BPUs) were fed to sixth-instar western spruce budworm, Choristoneura occidentalis Freeman. The BPUs tested were diflubenzuron, BAY SIR 8514 (N-[(trifluoromethoxy)phenyl]carbamoyl-2-chlorobenzamide), and EL-127063 (N-[[[5-(4-bromphenyl)-6-metnyl-2-pyrazinyl]amino]carbonyl]-2-chlorobenzamide). Mixtures consisted of JHA:BPU combined in 1:9 proportions. Ingestion of methoprene combined with BAY SIR 8514 or diflubenzuron resulted in significantly lower mortality than expected under a simple model of uncorrelated, independent action. Ingestion of the mixture of methoprene and EL-127063, however, resulted in significantly enhanced toxicity over the upper response range (> 50% mortality).
TEMPORAL DISTRIBUTION OF CRANE FLIES (DIPTERA: TIPULIDAE) IN A SOUTHERN NEW YORK WOODLAND
Authors: Knizeski Henry M. , Sullivan Daniel J. 
Published: December 2009

AbstractAdult tipulids were collected at weekly intervals in a southern New York open woodland. Sweeping, light trapping, and Malaise trapping yielded 4003 crane flies representing 125 species. The 25 most common species were identified and enumerated. The Malaise trap data were used to examine phenology, diversity, and species evenness. Further numerical analysis with the Malaise trap data indicated similarity among collecting periods. These results were used to outline the seasonal subcommunities that existed over a 2-year period.
CONELET ABORTION IN JACK PINE CAUSED BY PLATYLYGUS LURIDUS (HEMIPTERA: MIRIDAE)
Authors: Rauf Aunu , Cecich R. A. , Benjamin D. M. 
Published: December 2009

AbstractConelet abortion in a jack pine, Pinus banksiana Lamb., seed orchard in Oneida County, Wisconsin was caused by Platylygus luridus (Reuter) (Hemiptera: Miridae) and ranged from 51% to 87% with the average 74.5% in 3 of 4 years. Adults preferred to feed on ovules in conelets and were 3 to 4 times more destructive than nymphs. When conelets were protected from this insect by coating the twig above and below the conelet with Tanglefoot®, abortion was below 11%. Other mirid adults including Phytocoris michiganae Knight, Pilophorus amoenus Uhler, Dichrooscytus suspectus Reuter, and Europiella n.sp. confined in cages with conelets did not induce abortion.
ASSOCIATION BETWEEN A SUNFLOWER FUNGAL PATHOGEN, PHOMA MACDONALDII, AND A STEM WEEVIL, APION OCCIDENTALE (COLEOPTERA: CURCULIONIDAE)
Authors: Gaudet M. D. , Schulz J. T. 
Published: December 2009

AbstractThe presence of the fungus Phoma macdonaldii Boerema on the exocuticle of the adult stem weevil Apion occidentale Fall, was verified using isolation techniques and scanning electron microscopy. Pycnidiospores matching those of P. macdonaldii in size and shape were observed on the antennae, meso- and metathoracic legs of both field-collected and Phoma-incubated adults. Fungal hyphae were observed on the rostrum of both field-collected and laboratory-inoculated adults. Four percent of the weevils carried P. macdonaldii internally.
DESCRIPTION OF A NEW SPECIES OF CRICOTOPUS VAN DER WULP (DIPTERA: CHIRONOMIDAE) ASSOCIATED WITH MYRIOPHYLLUM SPICATUM
Authors: Oliver D. R. 
Published: December 2009

AbstractAll stages of Cricotopus (Isocladius) myriophylli n. sp. are described and differentiated from those of other members of the sylvestris group of Cricotopus van der Wulp. The larval diagnosis for the sylvestris group is emended.
SUSCEPTIBILITY OF LARVAL INSTARS OF SPRUCE BUDWORM, CHORISTONEURA FUMIFERANA (LEPIDOPTERA: TORTRICIDAE), TO BACILLUS THURINGIENSIS
Authors: Fast Paul G. , Dimond John B. 
Published: December 2009

AbstractDiet incorporation assays detected no difference in susceptibility of instars IV, V, and VI of spruce budworm exposed to Bacillus thuringiensis, either in terms of dose, LC50, or time, LT50. The hypothesis that the dose–response for larvae of each instar fitted a common regression line was statistically acceptable. Differences in the pattern of changes in larval weight of instars IV, V, VI larvae in response to dose were not detected.Small plots were sprayed with 5.5, 10.9, 21.9 BIU/ha at times corresponding to peak instar III, early IV, peak IV, peak V, and peak VI. Instar III larvae were controlled less effectively than were instar IV or V larvae which were controlled equally well. Instar VI larvae were also less effectively controlled than instar IV and V larvae probably because a significant proportion had reached the non-feeding prepupal stage before the full effect of B.t. was obtained.