bluuebunny/crossref_metadata_2025_split huggingface dataset:
GIS and cellular automata based slope rainwater movement process model and its application
Authors: Liu Lei , Chen Yu , Zhang Yanjun , Lian Zhipeng , Pei Laizheng , Liu Yalei 
Published: April 2024

AbstractRainfall serves as a significant factor contributing to slope stability challenges in mountainous areas, and simulating the process of slope rainwater movement is a crucial approach for analyzing the stability of slopes triggered by rainfall. By combining computer numerical simulation technology with traditional hydraulic and hydrological calculation theories, it is possible to create an efficient and precise rainwater movement model that can simulate and analyze the process of rainwater movement on slopes. Utilizing natural slopes as the focal point of our research, the cellular automaton method was applied to simulate rainfall runoff on slopes, and a Cellular Automata (CA) based model for rainwater movement process was developed. This model modified the Green-Ampt (G-A) infiltration model by adopting an elliptical water content curve and introducing a coefficient that quantifies the ratio of saturated to unsaturated depth. Additionally, we refined the rules governing runoff generation and convergence within the slope and on its surface, enabling a comprehensive simulation of the entire rainwater movement process on the slope. Furthermore, the effectiveness of the model was validated through analytical solutions derived from simplified assumptions, laboratory experiments on infiltration and runoff in the flume, and a case study of a natural slope. The results show that the infiltration calculation results of the rainwater movement model are closer to the experimental values, and their overall values are slightly higher than the measured values, which are basically consistent with the model test results; The runoff calculation results show a phenomenon of initially increasing and gradually approaching the measured values compared to the measured values. When applying the model to an actual slope, it was found that the model comprehensively accounts for the influence of slope seepage, infiltration and runoff process, has better performance compared to G-A modified model. The model can be used to describe the spatial distribution and temporal variation of infiltration and runoff processes.
Surgical treatment improves overall survival of hepatocellular carcinoma with extrahepatic metastases after conversion therapy: a multicenter retrospective study
Authors: Zhang Xiaoshi , Zhu Xiaodong , Zhong Jianhong , Zhao Yang , Zhang Xiaoyun , Zhang Wenwen , Ye Feng , Yang Chaoxu , Xue Jun , Xiong Rui , Wang Jiabei , Shen Shunli , Pan Yangxun , Li Dongxiao , Song Tianqiang , Bi Xinyu , Sun Huichuan , Xiang Bangde , Gu Shanzhi , Wen Tianfu , Lu Shichun , Chen Yongjun , Yin Tao , Liu Lianxin , Kuang Ming , Xu Li , Li Deyu , Cai Jianqiang 
Published: April 2024

AbstractSystemic therapy is typically the primary treatment choice for hepatocellular carcinoma (HCC) patients with extrahepatic metastases. Some patients may achieve partial response (PR) or complete response (CR) with systemic treatment, leading to the possibility of their primary tumor becoming resectable. This study aimed to investigate whether these patients could achieve longer survival through surgical resection of their primary tumor. We retrospectively collected data from 150 HCC patients with extrahepatic metastases treated at 15 different centers from January 1st, 2015, to November 30th, 2022. We evaluated their overall survival (OS) and progress-free survival (PFS) and analyzed risk factors impacting both OS and PFS were analyzed. Patients who received surgical treatment had longer OS compared to those who did not (median OS 16.5 months vs. 11.3 months). However, there was no significant difference in progression-free survival between the two groups. Portal vein invasion (P = 0.025) was identified as a risk factor for poor prognosis in patients, while effective first-line treatment (P = 0.039) and surgical treatment (P = 0.005) were protective factors. No factors showed statistical significance in the analysis of PFS. Effective first-line treatment (P = 0.027) and surgical treatment (P = 0.006) were both independent protective factors for prolonging patient prognosis, while portal vein invasion was an independent risk factor (P = 0.044). HCC patients with extrahepatic metastases who achieve PR/CR with conversion therapy may experience longer OS through surgical treatment. This study is the first to analyze the clinical outcomes of patients receiving surgical treatment for HCC with extrahepatic metastases.
Assessing the consequences of recent climate change on World Heritage sites in South Greenland
Authors: Hollesen Jørgen , Jepsen Malte Skov , Stendel Martin , Harmsen Hans 
Published: April 2024

AbstractIn the Arctic region, microbial degradation poses a significant threat to the preservation of archaeological deposits, actively consuming irreplaceable cultural and environmental records. In this study we assess the potential effects of the last 40 years of climate change on organic archaeological deposits within the UNESCO World Heritage area Kujataa in South Greenland. We use the dynamic process-oriented model, CoupModel to simulate soil temperatures and soil moisture contents at four archaeological sites in the area. The results show that the organic deposits have experienced a substantial warming the last 40 years, which combined with decreasing soil moisture contents creates a dangerous combination that can accelerate the degradation of organic materials. Currently, there are 583 archaeological sites registered within the area. Our findings highlight that the current climatic conditions are not conducive to organic preservation. The greatest risk of degradation lies within the relatively dry continental inland areas of the study region, where all Norse Viking Age settlements are situated. However, even at the "cold" and "wet" outer coast, the combined effects of rising summer temperatures and declining soil moisture levels may already be exerting a noticeable impact.
Impact of shear stress on sacral pressure injury from table rotation during laparoscopic colorectal surgery performed in the lithotomy position
Authors: Tatsuta Kyota , Sakata Mayu , Sugiyama Kosuke , Kojima Tadahiro , Akai Toshiya , Suzuki Katsunori , Torii Kakeru , Morita Yoshifumi , Kikuchi Hirotoshi , Hiramatsu Yoshihiro , Kurachi Kiyotaka , Takeuchi Hiroya 
Published: April 2024

AbstractThis study aimed to evaluate the impact of shear stress on surgery-related sacral pressure injury (PI) after laparoscopic colorectal surgery performed in the lithotomy position. We included 37 patients who underwent this procedure between November 2021 and October 2022. The primary outcome was average horizontal shear stress caused by the rotation of the operating table during the operation, and the secondary outcome was interface pressure over time. Sensors were used to measure shear stress and interface pressure in the sacral region. Patients were divided into two groups according to the presence or absence of PI. PI had an incidence of 32.4%, and the primary outcome, average horizontal shear stress, was significantly higher in the PI group than in the no-PI group. The interface pressure increased over time in both groups. At 120 min, the interface pressure was two times higher in the PI group than in the no-PI group (PI group, 221.5 mmHg; no-PI group, 86.0 mmHg;p < 0.01). This study suggested that shear stress resulting from rotation of the operating table in the sacral region by laparoscopic colorectal surgery performed in the lithotomy position is the cause of PI. These results should contribute to the prevention of PI.
Preliminary study on the optical diagnosis of orbital rhabdomyosarcoma by Raman spectroscopy
Authors: Jin Ling , Dai Nengli , Yang Xiaobo 
Published: April 2024

AbstractTo investigate the Raman spectral features of orbital rhabdomyosarcoma (ORMS) tissue and normal orbital tissue in vitro, and to explore the feasibility of Raman spectroscopy for the optical diagnosis of ORMS. 23 specimens of ORMS and 27 specimens of normal orbital tissue were obtained from resection surgery and measured in vitro using Raman spectroscopy coupled to a fiber optic probe. The important spectral differences between the tissue categories were exploited for tissue classification with the multivariate statistical techniques of principal component analysis (PCA) and linear discriminant analysis (LDA). Compared to normal tissue, the Raman peak intensities located at 1450 and 1655 cm−1 were significantly lower for ORMS (p < 0.05), while the peak intensities located at 721, 758, 1002, 1088, 1156, 1206, 1340, 1526 cm−1 were significantly higher (p < 0.05). Raman spectra differences between normal tissue and ORMS could be attributed to the changes in the relative amounts of biochemical components, such as nucleic acids, tryptophan, phenylalanine, carotenoid and lipids. The Raman spectroscopy technique together with PCA-LDA modeling provides a diagnostic accuracy of 90.0%, sensitivity of 91.3%, and specificity of 88.9% for ORMS identification. Significant differences in Raman peak intensities exist between normal orbital tissue and ORMS. This work demonstrated for the first time that the Raman spectroscopy associated with PCA-LDA diagnostic algorithms has promising potential for accurate, rapid and noninvasive optical diagnosis of ORMS at the molecular level.
Genetic interaction between TTG2 and AtPLC1 reveals a role for phosphoinositide signaling in a co-regulated suite of Arabidopsis epidermal pathways
Authors: Goldberg Aleah , O’Connor Patrick , Gonzalez Cassandra , Ouren Mason , Rivera Luis , Radde Noor , Nguyen Michael , Ponce-Herrera Felipe , Lloyd Alan , Gonzalez Antonio 
Published: April 2024

AbstractThe TTG2 transcription factor of Arabidopsis regulates a set of epidermal traits, including the differentiation of leaf trichomes, flavonoid pigment production in cells of the inner testa (or seed coat) layer and mucilage production in specialized cells of the outer testa layer. Despite the fact that TTG2 has been known for over twenty years as an important regulator of multiple developmental pathways, little has been discovered about the downstream mechanisms by which TTG2 co-regulates these epidermal features. In this study, we present evidence of phosphoinositide lipid signaling as a mechanism for the regulation of TTG2-dependent epidermal pathways. Overexpression of the AtPLC1 gene rescues the trichome and seed coat phenotypes of the ttg2-1 mutant plant. Moreover, in the case of seed coat color rescue, AtPLC1 overexpression restored expression of the TTG2 flavonoid pathway target genes, TT12 and TT13/AHA10. Consistent with these observations, a dominant AtPLC1 T-DNA insertion allele (plc1-1D) promotes trichome development in both wild-type and ttg2-3 plants. Also, AtPLC1 promoter:GUS analysis shows expression in trichomes and this expression appears dependent on TTG2. Taken together, the discovery of a genetic interaction between TTG2 and AtPLC1 suggests a role for phosphoinositide signaling in the regulation of trichome development, flavonoid pigment biosynthesis and the differentiation of mucilage-producing cells of the seed coat. This finding provides new avenues for future research at the intersection of the TTG2-dependent developmental pathways and the numerous molecular and cellular phenomena influenced by phospholipid signaling.
Extra-articular screw placement strategy in Stoppa approach based on three-dimensional reconstruction model
Authors: Zhang Ruipeng , Zhang Shaojuan , Zheng Xuehong , Yin Yingchao , Wang Zhongzheng , Tian Siyu , Hou Zhiyong , Zhang Yingze 
Published: April 2024

AbstractThe study aimed to explore an extra-articular screw placement strategy in Stoppa approach. Radiographic data of patients who underwent pelvic computed tomography from January 2016 to June 2017 were imported into Materiaise’s interactive medical image control system software for three-dimensional reconstruction. Superior and lower margins of acetabulum and ipsilateral pelvic brim could be observed simultaneously through inlet-obturator view. A horizontal line from superior acetabular margin intersected pelvic brim at point “A” and another vertical line from lower margin intersected pelvic brim at point “B” were drawn, respectively. Lengths form sacroiliac joint to “A” (a), “A” to “B” (b), and “B” to pubic symphysis (c) were measured. Patients were divided into four groups depending on gender and side difference of measured hemi-pelvis: male left, male right, female left, and female right. Lengths of adjacent holes (d) and spanning different holes (e) of different plates were also measured. Mean lengths of a, b, c in four groups were 40.94 ± 1.85 mm, 40.09 ± 1.93 mm, 41.78 ± 3.62 mm, and 39.77 ± 2.23 mm (P = 0.078); 40.65 ± 1.58 mm, 41.48 ± 1.64 mm, 40.40 ± 1.96 mm, and 40.66 ± 1.70 mm (P = 0.265); 57.03 ± 3.41 mm, 57.51 ± 3.71 mm, 57.84 ± 4.40 mm, and 59.84 ± 4.35 mm (P = 0.165), respectively. Mean d length of different plates was 12.23 mm. Average lengths spanning 1, 2, 3 and 4 holes were 19.33 mm, 31.58 mm, 43.80 mm, and 55.93 mm. Our data showed that zones a and c could be safely inserted three and four screws. Penetration into hip joint could be avoided when vacant 3-hole drilling was conducted in zone b. Fracture line in zone b could serve as a landmark for screw placement.
Lorlatinib in the second line and beyond for ALK positive lung cancer: real-world data from resource-constrained settings
Authors: Kumar Amit , Kapoor Akhil , Noronha Vanita , Patil Vijay , Menon Nandini , Singh Ajay Kumar , Joshi Amit , Janu Amit , Kaushal Rajiv Kumar , Pai Trupti , Chougule Anuradha , Shetty Omshree , Prabhash Kumar 
Published: May 2024

Abstract
Background
ALK-positive lung cancers are known to have favorable responses with oral tyrosine kinase inhibitors. Lorlatinib is an approved treatment option post first and second-line ALK inhibitors and is now also in first line. We present a retrospective observational study of the safety and efficacy of patients receiving Lorlatinib in second-line and beyond.

Methods
We conducted a retrospective observational study of ALK-positive patients who received Lorlatinib post-progression or intolerance to initial therapy at the Medical Oncology department. The patients who were started on Lorlatinib between January 2018 to December 2019 were included. The patients underwent routine blood and radiological evaluation every two to three months.

Results
A total of 38 patients received Lorlatinib in the specified period. The median age was 48 years (range 23–68), with 53% of patients being male, 37% having comorbidities; the most common being hypertension and diabetes and 79% of patients were of ECOG-PS1. Twenty-two patients (58%) had received two prior TKIs. The most common sites of metastasis before starting Lorlatinib were brain (55%) and bone (53%). All patients except one received prior whole-brain radiotherapy with 4 receiving radiation twice. The median follow-up period was 49 months (95% CI: 46.4–51.6). Eighty-four percent showed disease control with median progression-free survival (PFS) and overall survival (OS) of 16 months (95% CI 5.4–26.6) and 22 months (95% CI 9.9–34.1) respectively. Twelve patients died without documented progression. Five out of twelve with documented progression had brain involvement while six had lung involvement. Twelve out of twenty-four patients who progressed received subsequent chemotherapy. The most common grade 3 and above toxicities were hypercholesterolemia and hypertriglyceridemia. Three (7.8%) patients required dose reduction.

Conclusion
This real-world data confirms the efficacy of Lorlatinib in the second line and beyond with adverse effects matching that of registration studies.
Customized modulation on plasma uniformity by non-uniform magnetic field in capacitively coupled plasma
Authors: WANG 王 Sen 森 , ZHANG 张 Quanzhi 权治 , MA 马 Fangfang 方方 , YUSUPOV Maksudbek , WANG 王 Younian 友年 
Published: April 2024

Abstract
A two-dimensional fluid model based on COMSOL Multiphysics is developed to investigate the modulation of static magnetic field on plasma homogeneity in a capacitively coupled plasma (CCP) chamber. To generate a static magnetic field, direct current is applied to a circular coil located at the top of the chamber. By adjusting the magnetic field’s configuration, which is done by altering the coil current and position, both the plasma uniformity and density can be significantly modulated. In the absence of the magnetic field, the plasma density exhibits an inhomogeneous distribution characterized by higher values at the plasma edge and lower values at the center. The introduction of a magnetic field generated by coils results in a significant increase in electron density near the coils. Furthermore, an increase in the sets of coils improves the uniformity of the plasma. By flexibly adjusting the positions of the coils and the applied current, a substantial enhancement in overall uniformity can be achieved. These findings demonstrate the feasibility of using this method for achieving uniform plasma densities in industrial applications.
Moving for Grace: Motor-Aesthetic Properties and Dance Appreciation
Authors: Heckman Ian 
Published: April 2024

Abstract
Bodily responses to dance have sparked recent controversy in philosophy. Some people claim that they have no place in dance appreciation. Some use evidence from cognitive science to support the view that bodily responses have an important place in dance appreciation. However, this paper focuses not on whether motor responses to dance are part of dance appreciation but on their role in dance appreciation. It argues that many aesthetic qualities important to dance appreciation, such as gracefulness, are motor-aesthetic qualities, meaning that they require bodily response to appreciate them fully. It thus doubles not just as an analysis of motor response and its place in dance appreciation, but also as an analysis of gracefulness, a central aesthetic property in dance.
Investigating the relationship between prenatal alcohol exposure and children’s behavioural and emotional development: analysis of the Growing Up in New Zealand study
Authors: Chu Joanna Ting Wai , McCormack Jessica , Jiang Yannan , Walsh Daniel , Wilson Holly , Marsh Samantha , Langridge Fiona , Bullen Chris 
Published: April 2024

Abstract

Aims
To examine the relationship between prenatal alcohol exposure (PAE) and children’s behavioural and emotional development in a large generalizable sample of women and their children in Aotearoa New Zealand.

Methods
Using data from the Growing Up in New Zealand longitudinal cohort, we investigated the relationship between maternal PAE and behavioural and emotional development in 8-year-old children. We explored secondary outcomes including measures of language, executive function, academic achievement, and adaptive behaviour.

Results
We found no significant differences in the measures of behavioural and emotional development in children 8 years old based on alcohol consumption. No significant differences in behavioural and emotional development were found based on amount of PAE and when PAE occurred, despite controlling for a range of potential confounding factors, such as neighbourhood deprivation and maternal health measures. PAE was associated with significantly higher scores for parent-rated oral language indicating better oral language. In Māori mothers, PAE was significantly associated with an increased risk of higher scores on two of the Strengths and Difficulties Questionnaire subscales.

Conclusions
We did not find an association between PAE and behavioural and emotional development in children aged 8 years. PAE and behavioural and emotional development are difficult to measure accurately, and the moderating variables between them are complex. Future analyses will require larger cohorts of mothers and their children using precise measures of PAE and outcomes to enable more precise estimates of association.
CyclicPepedia: a knowledge base of natural and synthetic cyclic peptides
Authors: Liu Lei , Yang Liu , Cao Suqi , Gao Zhigang , Yang Bin , Zhang Guoqing , Zhu Ruixin , Wu Dingfeng 
Published: April 2024

AbstractCyclic peptides offer a range of notable advantages, including potent antibacterial properties, high binding affinity and specificity to target molecules, and minimal toxicity, making them highly promising candidates for drug development. However, a comprehensive database that consolidates both synthetically derived and naturally occurring cyclic peptides is conspicuously absent. To address this void, we introduce CyclicPepedia (https://www.biosino.org/iMAC/cyclicpepedia/), a pioneering database that encompasses 8744 known cyclic peptides. This repository, structured as a composite knowledge network, offers a wealth of information encompassing various aspects of cyclic peptides, such as cyclic peptides’ sources, categorizations, structural characteristics, pharmacokinetic profiles, physicochemical properties, patented drug applications, and a collection of crucial publications. Supported by a user-friendly knowledge retrieval system and calculation tools specifically designed for cyclic peptides, CyclicPepedia will be able to facilitate advancements in cyclic peptide drug development.
A speech fluency brain network derived from gliomas
Authors: Sun Cechen , Zhang Jie , Bu Linghao , Lu Junfeng , Yao Ye , Wu Jinsong 
Published: April 2024

AbstractThe brain network of speech fluency has not yet been investigated via a study with a large and homogenous sample. This study analysed multimodal imaging data from 115 patients with low-grade glioma to explore the brain network of speech fluency. We applied voxel-based lesion-symptom mapping to identify domain-specific regions and white matter pathways associated with speech fluency. Direct cortical stimulation validated the domain-specific regions intra-operatively. We then performed connectivity-behaviour analysis with the aim of identifying connections that significantly correlated with speech fluency. Voxel-based lesion-symptom mapping analysis showed that damage to domain-specific regions (the middle frontal gyrus, the precentral gyrus, the orbital part of inferior frontal gyrus and the insula) and white matter pathways (corticospinal fasciculus, internal capsule, arcuate fasciculus, uncinate fasciculus, frontal aslant tract) are associated with reduced speech fluency. Furthermore, we identified connections emanating from these domain-specific regions that exhibited significant correlations with speech fluency. These findings illuminate the interaction between domain-specific regions and 17 domain-general regions—encompassing the superior frontal gyrus, middle frontal gyrus, inferior frontal gyrus and rolandic operculum, superior temporal gyrus, temporal pole, inferior temporal pole, middle cingulate gyrus, supramarginal gyrus, fusiform gyrus, inferior parietal lobe, as well as subcortical structures such as thalamus—implicating their collective role in supporting fluent speech. Our detailed mapping of the speech fluency network offers a strategic foundation for clinicians to safeguard language function during the surgical intervention for brain tumours.