bluuebunny/crossref_metadata_2025_split huggingface dataset:
Palladium‐Catalyzed Dienylation of Haloalkynes using 2,3‐Butadienyl Acetates: A Facile Access to (1Z)‐1,2‐Dihalo‐ 3‐vinyl‐1,3‐dienes
Authors: Chen Dongxu , Chen Xiaoyi , Lu Zenghui , Cai Haiting , Shen Jinbei , Zhu Gangguo 
Published: June 2011

AbstractA highly efficient and stereoselective method for the synthesis of (1Z)‐1,2‐dihalo‐3‐vinyl‐1,3‐dienes featuring palladium‐catalyzed coupling of haloalkynes and 2,3‐butadienyl acetates was developed. The resulting products were smoothly converted into cis‐1,2‐dihalostyrene derivatives using the Diels–Alder/aromatization sequence.
Ellipsometric Investigation of the Shape of Nanodomains in Polymer/Fullerene Films
Authors: Engmann Sebastian , Turkovic Vida , Gobsch Gerhard , Hoppe Harald 
Published: June 2011

AbstractThe influence of the polymer/fullerene blend ratio on the morphological properties of organic solar cells is investigated. Spectroscopic ellipsometry is applied as a tool for analyzing fullerene domains and the influence on polymer crystallinity within the film. Furthermore, the measurements are correlated with a percolation limit of as‐cast films at around 40 wt% fullerene content.
Surface graft copolymerization of poly(methyl methacrylate) onto waste tire rubber powder through ozonization
Authors: Fan Ping , Lu Canhui 
Published: June 2011

AbstractGrinding of tires offers a promising opportunity for recycling waste rubber because fine waste tire rubber particle may be used as fillers and property modifiers in thermoplastic, elastomer, and thermoset blends. However, due to the lack of reactive sites on the WTR surface, the adhesion between WTR powder and matrix is poor. In this article, ozonization of waste tire rubber (WTR) powder was performed to produce some “immobile” reactive points (hydroperoxide groups) on the WTR surface. The free radical generated by the decomposition of hydroperoxide groups on WTR surface, was used to initiate graft polymerization of methyl methacrylate (MMA) onto the surface of WTR powder. The experimental results showed that MMA was successfully grafted onto the surface of WTR. The hydrophilicity of the MMA grafted WTR (MMA‐g‐WTR) was improved. The concentration of hydroperoxide groups and the graft degree were both increased with ozonization time. With increasing of polymerization time and polymerization temperature, the grafting degree increased. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Spectrofluorometric analysis and electrical conductivities of styrene and methylmethacrylate polymers by adding symmetrical polymethine dyes
Authors: Ramelow Ulku S. , Wagle Rajesh 
Published: June 2011

AbstractTo see the effect of conjugation on molecular weight and conductivity, three symmetrical polymethine dyes are added in polymers either before or after polymerization. Dyes have conjugated bonds between nitrogen atoms. Among three dyes, it was observed that as conjugation increases, the conductivity also increases. Previous study with polyethylvinylketone and polymethylvinylketone support the idea that increased conjugation will increase the molecular weight and conductivity. For these polymers also, the dopant, phosphorylchloride increased the conductivities due to the double bond being transferred to the main chain and increased conjugation. The same method developed in this work can be applied to methyl methacrylate and styrene polymers to see the relationship between molecular weight, conductivity, and fluorescence intensity. When dyes were added to methylmethacrylate and styrene monomers before polymerization, much higher conductivities were obtained. Conductivity values are directly proportional to the irradiation times and molecular weights. Four‐hour irradiation time results in a maximum molecular weight of 6.4 × 105 and a maximum conductivity of 2.25 μS for MMA polymers. Spectrofluorometric analysis of methyl methacrylate polymers indicates that as molecular weight of the dyes increases, the emission intensities at 375 and 425 nm also increases. In the same way, increased molecular weight of polymer also results higher emission intensities. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Surface modification of a thermoplastic polyurethane by low‐pressure plasma treatment to improve hydrophilicity
Authors: Alves Patrícia , Pinto Susana , de Sousa Hermínio C. , Gil Maria Helena 
Published: June 2011

AbstractThe performance of a material in a biological environment is mainly mediated by its surface properties and the combination of chemical, physical, biological, and mechanical properties required for a specific application. In this study, the surface of a thermoplastic polyurethane (TPU) material (Elastollan®1180A50) was successfully modified by plasma treatment. Two different working gases were studied: argon and oxygen, which promoted the incorporation of oxygen‐containing groups on the surface. The optimal plasma parameters were investigated by evaluating the wettability of the surfaces. Changes in the surface functional groups chemistry were studied using X‐ray photoelectron spectroscopy (XPS). The obtained results showed that the plasma treatment process caused surface modifications that, in all cases, increased the polar nature of the surface. In terms of the desirable properties, it was found that the best operational conditions were: 100 W gas plasma, under a pressure of 60 Pa for 3 min. Argon seems to be more efficient then oxygen, because lower water contact angle results were obtained. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Poly(ethyl glycol) assisting water sorption enhancement of poly(ε‐caprolactone) blend for drug delivery
Authors: Jiang Yuanqing , Mao Kunjian , Cai Xuehua , Lai Shijia , Chen Xiaoxia 
Published: June 2011

AbstractPoly(ε‐caprolactone) (PCL) has been thermally synthesized, and then fractionated to blend with poly(ethyl glycol) (PEG). Blend films of PCL and PEG have been prepared by solution casting. Fourier transform infrared spectrum and differential scanning calorimetry of the films have been carried out, and the results indicate some hydrogen bonding interaction between the two components, which is resulted from the carbonyl groups of PCL and the hydroxyl end‐groups of the low‐molecular‐weight PEG. Scanning electron microscope images of the blend films reveal porous network structures for their surfaces and for their inner parts and the porous structure becomes more pronounced with the increase of PEG in the blend film. Ibuprofen (IBU) was used as the model drug to test the drug release behavior for the PCL/PEG blend matrices. The results show that IBU could be released from the blend tablets rapidly, and the release rate increases with PEG content. Analysis of the release profiles indicates PCL erosion control release mechanism of pure PCL tablet, but drug diffusion control of the blend tablet, because PEG can absorb water to allow water feasible to diffuse into drug core and dissolve drug. Therefore, the interconnected channels in the blend matrices and the hydrophilic nature of PEG contribute to the improvement of the IBU release rate. The research indicates that drug release rate from PCL based material could be efficiently improved by addition of small amount of hydrophilic low‐molecular‐weight PEG. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Techno‐economic analysis of a lignocellulosic ethanol biorefinery with ionic liquid pre‐treatment
Authors: Klein‐Marcuschamer Daniel , Simmons Blake A. , Blanch Harvey W. 
Published: June 2011

AbstractLignocellulose dissolution in ionic liquids is a relatively new biomass pre‐treatment technology that is receiving growing interest from the biofuels community as a route to provide readily‐hydrolyzable holocellulose. Despite its proven advantages over other pre‐treatment technologies – including feedstock invariance, high monomeric sugar yields over short saccharification times, and extensive delignification – there are several core issues that stand in the way of commercialization. These include the relative high cost of the ionic liquids themselves, a lack of knowledge in terms of process considerations for a biorefinery based on these solvents, and scant information on the coproducts this pre‐treatment technology could provide to the marketplace. We present an initial techno‐economic model of a biorefinery that is based on the ionic liquid pre‐treatment technology and have identified, through a comprehensive sensitivity analysis, the most significant areas in terms of cost savings/revenue generation that must be addressed before ionic liquid pre‐treatment can compete with other, more established, pre‐treatment technologies. This report evaluates this new pre‐treatment technology through the perspective of a virtual operating biorefinery, and although there are significant challenges that must be addressed, there is a clear path that can enable commercialization of this novel approach. © 2011 Society of Chemical Industry and John Wiley & Sons, Ltd
Succinate production from sucrose by metabolic engineered escherichia coli strains under aerobic conditions
Authors: Wang Jian , Zhu Jiangfeng , Bennett George N. , San Ka‐Yiu 
Published: June 2011

AbstractTwo metabolically engineered E. coli strains HL2765k and HL27659k, while capable of producing succinate from glucose with high yields, are not able to grow and produce succinate on sucrose. Consequently, the pUR400 plasmid containing scrK, Y, A, B, and R genes was introduced into HL2765k and HL27659k, respectively. Shake flask culture studies showed that the resulting strains can utilize sucrose; the strain HL2765k pUR400 and HL27659k pUR400 can produce succinate aerobically with a molar yield of 0.78 ± 0.02 mol/mol and 1.35 ± 0.13 mol/mol, respectively. On introduction of the plasmid pHL413, which encodes the heterologous pyruvate carboxylase (PYC) from Lactococcus lactis, the molar succinate yield increased to 1.60 ± 0.01 mol of succinate per mole of sucrose by the HL2765k pUR400 pHL413 strain and to 1.84 ± 0.10 by the HL27659k pUR400 pHL413 strain. In aerobic batch bioreactor studies, the succinate production rate was faster, and succinate production reached 101.83 mM with a yield of 1.90 when dissolved oxygen (DO) was controlled at 40 ± 7%. In addition, the results showed that DO had an important effect on succinate production by influencing PYC activity. This work demonstrates the possibility of producing succinate aerobically using sucrose as the carbon source. © 2011 American Institute of Chemical Engineers Biotechnol. Prog., 2011
Paclitaxel delivery to brain tumors from hydrogels: A computational study
Authors: Torres Alexis J. , Zhu Charles , Shuler Michael L. , Pannullo Susan 
Published: June 2011

AbstractMalignant gliomas are aggressive forms of primary brain tumors characterized by a poor prognosis. The most successful treatment so far is the local implantation of polymer carriers (Gliadel® wafers) for the sustained release of carmustine. To improve the effectiveness of local drug treatment, new polymer carriers and pharmacological agents are currently being investigated. Of particular interest is a set of novel thermo‐gelling polymers for the controlled release of hydrophobic drugs such as paclitaxel (e.g., OncoGel™). Herein, we use computational mass transport simulations to investigate the effectiveness of paclitaxel delivery from hydrogel‐forming polymer carriers. We found similar (within 1–2 mm) therapeutic penetration distances of paclitaxel when released from these hydrogels as compared with carmustine released from Gliadel® wafers. Effective therapeutic concentrations were maintained for >30 days for paclitaxel when released from the hydrogel as compared with 4 days for carmustine released from Gliadel® wafers. Convection in brain tissue prevented the formation of a uniform drug concentration gradient around the implant. In addition, the surface area to volume ratio of the gel is an important factor that should be considered to maintain a controlled release of paclitaxel within the degradation lifetime of the polymer matrix. © 2011 American Institute of Chemical Engineers Biotechnol. Prog., 2011
Spectroscopic Investigation of Heterogeneous Ziegler–Natta Catalysts: Ti and Mg Chloride Tetrahydrofuranates, Their Interaction Compound, and the Role of the Activator
Authors: Seenivasan Kalaivani , Sommazzi Anna , Bonino Francesca , Bordiga Silvia , Groppo Elena 
Published: June 2011

AbstractX‐ray powder diffraction (XRPD), Infrared, Raman, and UV/Vis spectroscopy have been used to investigate the structural, vibrational, and optical properties of Ti and Mg chloride tetrahydrofuranates as precursors of heterogeneous Ziegler–Natta catalysts for polyethylene production; as well as their interaction compound (pro‐catalyst) and the final catalyst obtained after interaction with the AlR3 activator. Although the structure of the precursors and of the pro‐catalyst were well known, that of the catalyst (obtained by reaction of the pro‐catalyst with AlR3) was not easily obtainable from XRPD data. IR and Raman spectroscopy provided important information on tetrahydrofuran (thf) coordination and on the ν(MCl) region; whereas UV/Vis spectroscopy gave the direct proof on both the formal oxidation state and the coordination environment of the active Ti sites. Those presented herein are among the first direct experimental data on the structure of the active Ti sites in Ziegler–Natta catalysts, and can be used to validate the many computational studies that have been increasing exponentially in the last few decades.
ChemInform Abstract: Enhanced Visible‐Light‐Response Photocatalytic Activity of Bismuth Ferrite Nanoparticles.
Authors: Wang Xiong , Lin Ying , Ding Xifeng , Jiang Jinguo 
Published: June 2011

AbstractBiFeO3 nanoparticles with an average size of 35 nm are synthesized by a sol—gel method from a solution of Bi(NO3)3 and Fe(NO3)3 in ethylene glycol and heating of the obtained xerogel at 500 °C [0.5 h].
ChemInform Abstract: Phase‐Selective Chemical Extraction of Selenium and Sulfur from Nanoscale Metal Chalcogenides: A General Strategy for Synthesis, Purification, and Phase Targeting.
Authors: Sines Ian T. , Schaak Raymond E. 
Published: June 2011

AbstractSelenium‐ or sulfur‐rich metal chalcogenides are chemically transformed into lower‐chalcogen compounds by reaction with trioctylphosphine at temperatures that range from 65 to 270 °C.
ChemInform Abstract: Microwave Synthesis, Structure, and Magnetic Properties of Quasi‐one‐Dimensional Complex Oxide Sr4LiMn2O9.
Authors: Bazuev G. V. , Tyutyunnik A. P. , Berger I. F. , Nikolaenko I. V. , Golovkin B. G. 
Published: June 2011

AbstractThe phase‐pure title compound is synthesized by solid state reaction of SrCO3 and LiMn2O4 in a microwave furnace (700 W, 2450 MHz).
ChemInform Abstract: Synthesis and Reactivity Studies of a New Reagent, Ethyltriphenylphosphonium Tribromide.
Authors: Jamir Latonglila , Alimenla B. , Kumar Anil , Sinha Dipak , Sinha Upasana B. 
Published: June 2011

AbstractTitle reagent is synthesized and successfully used for bromination and acylation reactions as well as for the synthesis of isothiocyanates (XI) from freshly prepared dithiocarbamate salts (X).
ChemInform Abstract: Iron‐Catalyzed Direct Amination of Azoles Using Formamides or Amines as Nitrogen Sources in Air.
Authors: Wang Jian , Hou Ji‐Ting , Wen Jun , Zhang Ji , Yu Xiao‐Qi 
Published: June 2011

AbstractA new catalytic system for decarbonylative coupling between azoles (I) and (IV) and formamides (II) and (VI) is described.
ChemInform Abstract: Gold(III) Complexes Catalyze Deoximations/Transoximations at Neutral pH.
Authors: Isart Carles , Bastida David , Bures Jordi , Vilarrasa Jaume 
Published: June 2011

AbstractThe AuBr3‐catalyzed deoximination by transoximination with diacetyl proceeds under mild conditions.
ChemInform Abstract: Selective Deoxygenation of Epoxides to Alkenes with Molecular Hydrogen Using a Hydrotalcite‐Supported Gold Catalyst: A Concerted Effect Between Gold Nanoparticles and Basic Sites on a Support.
Authors: Noujima Akifumi , Mitsudome Takato , Mizugaki Tomoo , Jitsukawa Koichiro , Kaneda Kiyotomi 
Published: June 2011

AbstractGold on hydrotalcite nanoparticles with a diameter <3 nm selectively catalyzes the hydrogenolytic deoxygenation of oxiranes to olefins.
ChemInform Abstract: Remarkable Rate Acceleration of Baylis—Hillman Reaction of Notorious α,β‐Unsaturated Aldehydes Catalyzed by Proton Donor.
Authors: Kim Ko Hoon , Lee Hyun Seung , Kim Yu Mi , Kim Jae Nyoung 
Published: June 2011

AbstractA series of various Baylis—Hillman adducts of α,β‐unsaturated aldehydes is synthesized using excess amounts of DABCO and phenol additive.
ChemInform Abstract: Complete Stereocontrol in Organocatalytic Additions of β‐Ketosulfoxides to Conjugated Aldehydes.
Authors: Garcia Ruano Jose Luis , Alvarado Cuauhtemoc , Diaz‐Tendero Sergio , Aleman Jose 
Published: June 2011

AbstractMichael addition of enantiomerically pure β‐ketosulfoxides towards α,β‐unsaturated aldehydes proceeds with excellent stereocontrol in the presence of a prolinol‐derived organocatalyst to give the adducts containing three contiguous stereocenters (III) as single diastereomers.
ChemInform Abstract: Nickel‐Catalyzed Cross‐Coupling of Phenols and Arylboronic Acids Through an in situ Phenol Activation Mediated by PyBroP.
Authors: Chen Guo‐Jun , Huang Jie , Gao Lian‐Xun , Han Fu‐She 
Published: June 2011

AbstractSuzuki—Miyaura cross coupling of phenols with arylboronic acids proceeds smoothly by preactivation of the phenols with PyBroP and subsequent Ni‐catalyzed coupling reaction.
ChemInform Abstract: Synthesis of 3‐Aryl‐3‐pyrrolines and 3‐Arylpyrroles via Spontaneous Rearrangement of N‐Sulfinyl 2‐Aryl‐2‐vinylaziridines.
Authors: Leemans Erika , Colpaert Filip , Mangelinckx Sven , De Brabandere Stijn , Denolf Bram , De Kimpe Norbert 
Published: June 2011

AbstractThe addition of vinylmagnesium bromide to ketimines (I) forms intermediate 2‐aryl‐2‐vinylaziridines which spontaneously rearrange to 3‐pyrrolines (III).
ChemInform Abstract: Pd‐Catalyzed Bicyclization to the Mitosene Skeleton.
Authors: Pyeon Hyeyoung , Pyo Sung Hwan , Ahn Jeong Keun , Kim Guncheol 
Published: June 2011

AbstractIntramolecular bicyclization of substituted substrates (I) affords the pyrroloindoles (II) with the common mitosene skeleton.
ChemInform Abstract: One Approach to Cyclic Carbonates via a Three‐Component Cyclization of Phenacyl Bromide, CO2, and Aldehyde.
Authors: Yan Peng , Tan Xueqin , Jing Huanwang , Duan Shuhui , Wang Xiaoxuan , Liu Zhongli 
Published: June 2011

AbstractIt provides a new and extremely mild method to prepare a wide range of target compounds.
ChemInform Abstract: Saccharomyces cerevisiae Catalyzed One‐Pot Three‐Component Synthesis of 2,3‐Diaryl‐4‐thiazolidinones
Authors: Pratap Umesh R. , Jawale Dhanaji V. , Bhosle Manisha R. , Mane Ramrao A. 
Published: June 2011

Abstractas a cost‐effective and environmentally friendly procedure
ChemInform Abstract: Highly Effective and Enantioselective Michael Addition of 4‐Hydroxycoumarin to α,β‐Unsaturated Ketones Promoted by Simple Chiral Primary Amine Thiourea Bifunctional Catalysts.
Authors: Mei Ren‐Qiang , Xu Xiao‐Ying , Li Yan‐Chun , Fu Ji‐Ya , Huang Qing‐Chun , Wang Li‐Xin 
Published: June 2011

AbstractAmong various thioureas tested, ATC is found to be the most efficient one.
ChemInform Abstract: Antiviral Agents. Part 3. Discovery of a Novel Small Molecule Non‐Nucleoside Inhibitor of Hepatitis B Virus (HBV).
Authors: Crosby Ian T. , Bourke David G. , Jones Eric D. , Jeynes Tyrone P. , Cox Susan , Coates Jonathan A. V. , Robertson Alan D. 
Published: June 2011

AbstractCompound (I) is found to be a potent inhibitor of HBV and also an inhibitor of Hepatitis B Virus resistant to 3TC.
ChemInform Abstract: Anticonvulsant Activity of a Combined Pharmacophore of Pyrazole‐Pyridines with Lesser Toxicity in Mice.
Authors: Siddiqui Nadeem , Ahsan Waquar , Alam M. Shamsher , Ali Ruhi , Srivastava Kamna , Ahmed Sharique 
Published: June 2011

AbstractClubbing two active pharmacophores, pyrazole and pyridine, affords a new structural class of anticonvulsants which display comparable anticonvulsant activity to standard drugs with markedly lower neurotoxicity and hepatotoxicity.
ChemInform Abstract: A Stereoselective Approach to 6‐Alkylated Piperidinone & 2‐Piperidine via Three‐Component Vinylogous Mannich Reactions (VMR) and a Concise Synthesis of (S)‐Anabasine.
Authors: Yang Yang , Phillips Dean P. , Pan Shifeng 
Published: June 2011

AbstractStarting from commercial chiral naphthylethylamine (I) and aldehydes, a stereoselective access to amino carboxylic acids of type (IV) and (IX) (no yield given) is developed.
ChemInform Abstract: I2‐Induced Stereospecific Synthesis of 4‐Piperidones Through Double Mannich Reaction and Tandem Cyclization.
Authors: Jia Xiao‐Dong , Chen Xiang‐Ning , Wang Xiao‐E , Huo Cong‐De , Wang Wen‐Juan , Ren Yan , Wang Xi‐Cun 
Published: June 2011

AbstractIodine‐catalyzed double Mannich reaction—cyclization sequence of a variety of aromatic imines with ketones provides access towards triarylpiperidones containing three stereocenters (III) as single diastereoisomers.
ChemInform Abstract: A Convenient Synthesis of Benzofuro[3,2‐c]isoquinolines and Naphtho[1′,2′:4,5]furo[3,2‐c]isoquinolines.
Authors: Kalugin Victor E. , Shestopalov Anatoly M. 
Published: June 2011

AbstractThe products are of interest as scaffolds in drug synthesis.
ChemInform Abstract: Novel Four‐Component Reaction Towards Diastereoselective Synthesis of Tetrahydropyrimidinethiones.
Authors: Wan Jie‐Ping , Wang Chunping , Pan Yuanjiang 
Published: June 2011

AbstractThe reaction of enaminones (I), benzaldehydes (II), anilines (III), and thiourea proceeds in the manner of specific diastereoselectivity with all‐cis relationship of the substituents at the resulting pyrimidinethiones.
ChemInform Abstract: Solvent‐Free Reaction Between Anthanilic Acids and Isocyanides: A Novel Approach for the Synthesis of 2‐Unsubstituted 4(3H)‐Quinazolinones.
Authors: Adib Mehdi , Karimzadeh Morteza , Mahdavi Mohammad , Sheikhi Ehsan , Mirzaei Peiman 
Published: June 2011

AbstractThe simple procedure allows the preparation of the heterocyclic scaffold (III) (12 examples), which is of interest in the preparation of tyrosine kinase inhibitors, in good to excellent yields.
ChemInform Abstract: A Novel Synthesis of (Di)‐Benzazocinones via an Endocyclic N‐Acyliminium Ion Cyclization.
Authors: King Frank D. , Aliev Abil E. , Caddick Stephen , Tocher D. A. 
Published: June 2011

AbstractTriflic acid‐mediated cyclization of endocyclic N‐acyliminium ions towards aryl rings provides access towards benzazocinones, e.g. (III), (VI) or (XII).
ChemInform Abstract: Discovery of Potent and Long‐Acting Oral Factor Xa Inhibitors with Tetrahydroisoquinoline and Benzazepine P4 Motifs.
Authors: Young Robert J. , et al. et al. 
Published: June 2011

AbstractDiscovery and evaluation of potent and long‐acting oral sulfonamidopyrrolidin‐2‐one factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs are reported.
ChemInform Abstract: Gold‐Catalyzed Activation of Epoxides: Application in the Synthesis of Bicyclic Ketals.
Authors: Balamurugan Rengarajan , Kothapalli Raveendra Babu , Thota Ganesh Kumar 
Published: June 2011

AbstractA series of alkynyl epoxides is converted into the bicyclic ketals as mixtures of diastereomers under catalysis of cationic Au(I) generated from a combination of AuCl(PPh3) and AgSbF6.
ChemInform Abstract: Role of Hydroxymethyl Group as a New Hydrophilic 4′‐Pocket in 5′‐Norcarbocyclic Nucleoside Analogues.
Authors: Liu Lian Jin , Hong Joon Hee 
Published: June 2011

AbstractIn order to investigate the relationship between the 4′‐group and antiviral enhancement, novel 4′‐hydroxymethyl‐5′‐norcarbocyclic adenosine phosphonic acid analogues are synthesized from ethanol derivative (I) utilizing reiterative Grignard addition and ring‐closing metathesis as key reactions.