bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Regiodivergent Ligand‐Controlled Rhodium‐Catalyzed [(2 + 2) + 2] Carbocyclization Reactions with Alkyl Substituted Methyl Propiolates.
Authors: Evans P. Andrew , Sawyer James R. , Inglesby Phillip A. 
Published: November 2010

AbstractIn the title reaction the selective formation of either regioisomer can be controlled through choice of the ligands.
ChemInform Abstract: Chiral Broensted Acid Catalyzed Regio‐ and Enantioselective Arylation of α,β‐Unsaturated Trifluoromethyl Ketones.
Authors: Pei Zeng‐kai , Zheng Yan , Nie Jing , Ma Jun‐An 
Published: November 2010

AbstractABN is the most efficient catalyst to give 3‐substituted indoles in moderate to good enantioselectivity.
ChemInform Abstract: Highly Regioselective Palladium‐Catalyzed Direct Arylation of Oxazole at C‐2 or C‐5 with Aryl Bromides, Chlorides, and Triflates.
Authors: Strotman Neil A. , Chobanian Harry R. , Guo Yan , He Jiafang , Wilson Jonathan E. 
Published: November 2010

AbstractTreatment of oxazole with aryl halides and triflates in the presence of Pd(OAc)2 and POS or APO results in efficient and selective formation of C‐5 arylated oxazoles.
ChemInform Abstract: Copper‐Catalyzed Synthesis of N‐Fused Heterocycles Through Regioselective 1,2‐Aminothiolation of 1,1‐Dibromoalkenes.
Authors: Xu Hui , Zhang Yin , Huang Jianqiang , Chen Wanzhi 
Published: November 2010

AbstractCu‐catalyzed treatment of the heterocyclic thiols (I), (VIII), (XIII), and (XV) and the thione (X) with 1,1‐dibromoalkenes allows a new and facile access to fused thiazoles and thiazines.
ChemInform Abstract: Synthesis of Fluorinated 2,3‐Dihydropyran‐4‐ones by Cyclocondensation of 1,3‐Dicarbonyl Dianions with Aldehydes.
Authors: Khera Rasheed Ahmad , Hussain Munawar , Ahmad Rasheed , Saeed Aamer , Villinger Alexander , Fischer Christine , Langer Peter 
Published: November 2010

AbstractThe reaction mechanism comprises attack of a LDA‐derived dianion to the aldehyde and subsequent acid‐mediated cyclization.
ChemInform Abstract: Synthesis and Biological Evaluation of Some Innovative Coumarin Derivatives Containing Thiazolidin‐4‐one Ring.
Authors: RamaGanesh C. K. , Bodke Yadav D. , Venkatesh K. B. 
Published: November 2010

AbstractAmong 5 derivatives prepared, products (VI) exhibit a good analgesic activity.
ChemInform Abstract: One‐Pot Synthesis of Pyrano[3,4‐b]chromones from Chromone‐3‐carbaldehyde.
Authors: Panja Suman Kalyan , Maiti Sourav , Banerjee Subhabrata , Bandyopadhyay Chandrakanta 
Published: November 2010

Abstract3‐Formylchromones react with cyclohexyl isocyanide to give the target compounds which constitute the central part of naturally occurring rotenone and analogues.
ChemInform Abstract: Efficient Synthesis of Biflavones Having a Ring‐A Ring of Two Flavone Units Using Suzuki Cross‐Coupling Reactions.
Authors: Kohari Yoshihito , Hoshino Yukio , Matsuyama Haruo , Nakano Hiroto 
Published: November 2010

AbstractSymmetric and unsymmetric biflavones are synthesized by the title reactions between borylated flavones (I) and (VI) and bromoflavones (II) and (IV) or flavonetriflate (VIII).
ChemInform Abstract: K2CO3‐Assisted One‐Pot Sequential Synthesis of 2‐Trifluoromethyl‐6‐difluoromethylpyridine‐3,5‐dicarboxylates under Solvent‐Free Conditions.
Authors: Shen Li , Cao Song , Wu Jingjing , Li Hui , Zhang Jian , Wu Mingxi , Qian Xuhong 
Published: November 2010

AbstractHantzsch reaction of ethyl trifluoroacetate at high temperature affords the synthetically and pharmaceutically important polysubstituted pyridines (III) as single products.
ChemInform Abstract: Synthesis of New Quinoline Derivatives as Inhibitors of Human Tumor Cells Growth.
Authors: Rashad Aymn E. , El‐Sayed Wael A. , Mohamed Ashraf M. , Ali Mamdouh M. 
Published: November 2010

AbstractQuinoline derivatives substituted with tetrazolyl or triazolyl moieties, as well as their glycoside derivatives are synthesized to find new leads for anticancer screening.
ChemInform Abstract: Three‐Component Reactions of 2‐Alkynylbenzaldoximes and α,β‐Unsaturated Carbonyl Compounds with Bromine or Iodine Monochloride.
Authors: Ye Shengqing , Gao Ke , Wu Jie 
Published: November 2010

AbstractTitle reaction proceeds readily in the system LiOH—DMF to afford isoquinolines such as (III), (V) in good yields.
ChemInform Abstract: Magnetically Recoverable Iron Nanoparticle Catalyzed Cross‐Dehydrogenative Coupling (CDC) Between Two Csp3—H Bonds Using Molecular Oxygen.
Authors: Zeng Tieqiang , Song Gonghua , Moores Audrey , Li Chao‐Jun 
Published: November 2010

AbstractOptimized conditions are developed for the oxidative coupling of tetrahydroisoquinolines with nitroalkanes or acetone.
ChemInform Abstract: Indolizine Studies. Part 5. Indolizine‐2‐carboxamides as Potential HIV‐1 Protease Inhibitors.
Authors: Tukulula Matshawandile , Klein Rosalyn , Kaye Perry T. 
Published: November 2010

AbstractCoupling of Baylis—Hillman‐derived indolizine‐2‐carboxylic acids (I) with various amine and amino acid derivatives provides access to corresponding carboxamides as truncated ritonavir analogues.
ChemInform Abstract: An Efficient Synthesis of Fused 3‐Formylpyridines and 5‐Formylpyrimidines.
Authors: Mityuk Andrey P. , Kolodych Sergey E. , Mytnyk Sergey A. , Dmytriv Yuri V. , Volochnyuk Dmitriy M. , Mykhailiuk Pavel K. , Tolmachev Andrey A. 
Published: November 2010

AbstractCyclocondensation of a variety of amino heterocycles with the trisformylmethane synthon (II) offers a useful access to the title compounds in varying yields.
ChemInform Abstract: Silver‐ and Gold‐Mediated Intramolecular Cyclization to Substituted Tetracyclic Isoquinolizinium Hexafluorostilbates.
Authors: Liu Fang , Ding Xiao , Zhang Lei , Zhou Yu , Zhao Linxiang , Jiang Hualiang , Liu Hong 
Published: November 2010

AbstractThe method provides a convenient approach to tetracyclic isoquinolizinium compounds which are of biological interest.
ChemInform Abstract: The Efficient One‐Step Chlorination of Methylsulfanyl Group on Pyrimidine Ring System with Sulfuryl Chloride.
Authors: Ham Young Jin , Lee Duck‐Hyung , Choi Hwan Geun , Hah Jung‐Mi , Sim Taebo 
Published: November 2010

AbstractThe process is superior to a precedent one using chlorine gas.
ChemInform Abstract: Synthesis and Antiinflammatory Activity of Some 3‐(4,6‐Disubstituted‐2‐thioxo‐1,2,3,4‐tetrahydropyrimidin‐5‐yl) propanoic Acid Derivatives.
Authors: Mokale Santosh N. , Shinde Sandeep S. , Elgire Rupali D. , Sangshetti Jaiprakash N. , Shinde Devanand B. 
Published: November 2010

AbstractMost of the synthesized novel propanoic acid derivatives (IV) show significant anti‐inflammatory activity comparable to that of diclofenac.
ChemInform Abstract: Enantioselective Biocatalytic Synthesis of (S)‐Monastrol.
Authors: Blasco Maria Alfaro , Thumann Silvia , Wittmann Juergen , Giannis Athanassios , Groeger Harald 
Published: November 2010

AbstractThe first enantioselective biocatalytic synthesis of (S)‐monastrol (II) is developed via an unexpected and unusual enzymatic pathway.
ChemInform Abstract: One‐Pot Two‐Step Synthesis of N3‐Functionalized 3,4‐Dihydropyrimidinones in the Presence of TMSCl.
Authors: Quan Zheng‐Jun , Ren Rong‐Guo , Da Yu‐Xia , Zhang Zhang , Jia Xiao‐Dong , Yang Cai‐Xia , Wang Xi‐Cun 
Published: November 2010

AbstractN‐3‐substituted dihydropyrimidinones are regioselectively prepared by using the title procedure concerning the reaction between dihydropyrimidinones, paraformaldehyde (II), chlorotrimethylsilane, alcohols, secondary amine, and sodium salts.
ChemInform Abstract: Zn[(L)Proline]2: An Efficient Catalyst for the Synthesis of Biologically Active Pyrano[2,3‐d]pyrimidine Derivatives
Authors: Heravi Majid M. , Ghods Azadeh , Bakhtiari Khadijeh , Derikvand Fatemeh 
Published: November 2010

Abstractvia three‐component one‐pot condensation of barbituric acid with benzaldehydes and malononitrile
ChemInform Abstract: Efficient, Ecofriendly, and Practical Process for the Synthesis of Quinoxalines Catalyzed by Amberlyst‐15 in Aqueous Media.
Authors: Liu Ju‐Yan , Liu Jing , Wang Jia‐Di , Jiao De‐Quan , Liu Hai‐Wang 
Published: November 2010

AbstractThe scope of the reaction is evaluated.
ChemInform Abstract: Domino Approach for the Synthesis of Pyrrolo[1,2‐α]pyrazine from Vinyl Azides.
Authors: Chen Wenteng , Hu Miao , Wu Jianwei , Zou Hongbin , Yu Yongping 
Published: November 2010

AbstractMichael addition of pyrrole (II) to a broad spectrum of vinyl azides is followed by N2 elimination and intramolecular condensation to give the synthetically important heterocyclic skeleton.
ChemInform Abstract: Enantioselective Synthesis of SSR 241586 by Using an Organo‐Catalyzed Henry Reaction.
Authors: Cochi Anne , Metro Thomas‐Xavier , Gomez Pardo Domingo , Cossy Janine 
Published: November 2010

AbstractAddition of nitromethane to the keto ester (I) in the presence of QUI and subsequent cyclization of the amide (IV) allows formation of the biologically active title compound (VI) with high enantioselectivity.
ChemInform Abstract: Azinyl Sulfides. Part 120. 2‐Methyl‐ and 2‐Dimethylaminoquino[4,3‐e]‐1,2,4‐thiadiazine 4,4‐Dioxides — Synthesis, Structure and N‐Methylation.
Authors: Chrobak Elwira , Wleklinski Michal , Maslankiewicz Andrzej , Kusz Joachim , Zubko Maciej , Zieba Andrzej 
Published: November 2010

AbstractQuinoline derivative (I) reacts with acetamidine (II) or N,N‐dimethyl‐ and N,N,N‐trimethylguanidine sulfates (VI) and (X) directly or stepwise via quinolinesulfonylguanidine (VII) to the 2‐substituted quinothiadiazine dioxides (III), (VIII), and (XI).
ChemInform Abstract: Facile Chemoselective Synthesis of Novel 6‐Aryl‐12H‐indolo[2,3‐e][1,4]benzodiazocine Derivatives by the Reaction of 3‐Aroylmethylene‐2H‐indol‐2‐ones with o‐Phenylenediamine.
Authors: Singh Pahup , Dandia Anshu , Khandelwal Poonam 
Published: November 2010

AbstractThe desired ring system (III) can be prepared at best under microwave irradiation in the presence of o‐phenylenediamine.
ChemInform Abstract: Nucleophilic Cycloaromatization of Ynamide‐Terminated Enediynes.
Authors: Poloukhtine Andrei , Rassadin Valentin , Kuzmin Alexander , Popik Vladimir V. 
Published: November 2010

AbstractIn the presence of acid, the enediynes (I) undergo facile cycloaromatization to naphthalene derivatives like (III), (IV), and (VI).
ChemInform Abstract: A Novel, Broad‐Spectrum Anticancer Compound Containing the Imidazo[4,5‐e][1,3]diazepine Ring System.
Authors: Xie Min , Ujjinamatada Ravi K. , Sadowska Mariola , Lapidus Rena G. , Edelman Martin J. , Hosmane Ramachandra S. 
Published: November 2010

AbstractSynthesis and broad‐spectrum anticancer activity of novel compounds containing the title diazepine ring system are reported.
ChemInform Abstract: Diels—Alder Chemistry of Siloles and Their Transformation into Cyclohex‐2‐ene‐1,4‐cis‐diols.
Authors: Stevens Andrew C. , Pagenkopf Brian L. 
Published: November 2010

AbstractSiloles, which can be prepared from 1,3‐dienes, smoothly react with diverse dienophiles to afford bridged compounds with complete endo selectivity.
ChemInform Abstract: [4 + 2] Cycloadditions of 1‐Phosphono‐1,3‐butadienes with Nitroso Heterodienophiles: A Versatile Synthetic Route for Polyfunctionalized Aminophosphonic Derivatives.
Authors: Monbaliu Jean‐Christophe , Tinant Bernard , Marchand‐Brynaert Jacqueline 
Published: November 2010

AbstractAddition of o‐nitrosotoluene or acylnitroso compounds (generated in situ) to the dienes (I) provides an efficient approach to phosphonylated oxazines of type (III) and (XII).
ChemInform Abstract: Iron‐Catalyzed Oxidative Mono‐and Bis‐phosphonation of N,N‐Dialkylanilines.
Authors: Han Wei , Mayer Peter , Ofial Armin R. 
Published: November 2010

AbstractThe oxidative α‐phosphonation of N,N‐dialkylaniline derivatives is achieved under mild conditions using environmentally benign FeCl2 as catalyst and tert‐butyl hydroperoxide as oxidant.
ChemInform Abstract: Microwave‐Assisted Synthesis of Diaryl Selenides. Elucidation of Cu(I)‐Catalyzed Reaction Mechanism.
Authors: Beletskaya Irina P. , Sigeev Alexander S. , Peregudov Alexander S. , Petrovskii Pavel V. , Khrustalev Victor N. 
Published: November 2010

AbstractA novel microwave‐assisted cross‐coupling of trialkyltin arylselenides (I) with arylbromides (II) using a Cu(I) catalyst affords unsymmetrical diarylselenides (III).
ChemInform Abstract: Cleavage of C—S and O—H Bonds by Platinum(0) Complexes to Give Five‐Membered 1,2‐Oxaplatinacycles.
Authors: Nakata Norio , Furukawa Noriyuki , Toda Tomoyuki , Ishii Akihiko 
Published: November 2010

Abstract1,2‐Oxaplatinacycles (III) are formed unexpectedly from 2‐hydroxybenzyl sulfide derivatives (I) by bond cleavage mediated by platinum(0).
ChemInform Abstract: Enantioselective Formal Synthesis of (‐)‐Englerin A (V) via a Rh‐Catalyzed [4 + 3] Cycloaddition Reaction.
Authors: Xu Jing , Caro‐Diaz Eduardo J. E. , Theodorakis Emmanuel A. 
Published: November 2010

AbstractThe key step in the synthesis of tricyclic alcohol (IV), is a stereoselective [4 + 3] cycloaddition of furan (II) with the diazo ester (I).
ChemInform Abstract: Diastereoselective Formal Total Synthesis of (.+‐.)‐Triptolide via a Novel Cationic Cyclization of 2‐Alkenyl‐1,3‐dithiolane (II).
Authors: Goncalves Sylvie , Hellier Paul , Nicolas Marc , Wagner Alain , Baati Rachid 
Published: November 2010

AbstractThe up to date most concise total synthesis affords title compound (IV) in 9 steps with an overall yield of 17%.
ChemInform Abstract: Iwayoside A, a New Diterpene Glycoside from Artemisia iwayomogi Kitamura that Enhances IL‐2 Secretion.
Authors: Ding Yan , Liang Chun , Yang Seo Young , Kim Jun Ho , Lee Young Mi , Kim Young Ho 
Published: November 2010

AbstractIwayoside A (I), a new diterpene glycoside is isolated from the title perennial herb together with two known monoterpenes.
ChemInform Abstract: Production of Sesquiterpene‐Type Phytoalexins by Hairy Roots of Hyoscyamus albus Cotreated with Copper Sulfate and Methyl Jasmonate
Authors: Kawauchi Morihiro , Arima Toshihide , Shirota Osamu , Sekita Setsuko , Nakane Takahisa , Takase Yoichi , Kuroyanagi Masanori 
Published: November 2010

Abstractisolation and structure of four new phytoalexins (I)
ChemInform Abstract: A New Synthetic Strategy for 2‐Deoxy‐D‐ribose via Palladium(II)‐Catalyzed Cyclization of Aldehyde.
Authors: Miyazawa Masahiro , Awasaguchi Ken‐ichiro , Uoya Ikuyo , Yokoyama Hajime , Hirai Yoshiro 
Published: November 2010

AbstractThe total synthesis of 2‐deoxy‐D‐ribose (VIII) is achieved in 12 steps from L‐(‐)malic acid (I) via an unstable hemiacetal.
ChemInform Abstract: Copper‐Catalyzed Intramolecular N‐Arylation of Quinazolinones: Facile Convergent Approach to (‐)‐Circumdatins H (IIIb) and J (IIIc).
Authors: Kshirsagar Umesh A. , Argade Narshinha P. 
Published: November 2010

AbstractKey step is a new Cu‐catalyzed cyclization of quinazolinones of type (II).
ChemInform Abstract: Catalytic Selective Cyclizations of Aminocyclopropanes: Formal Synthesis of Aspidospermidine and Total Synthesis of Goniomitine.
Authors: De Simone Filippo , Gertsch Juerg , Waser Jerome 
Published: November 2010

AbstractSelective cyclization of aminocyclopropanes at either the N1 or C3 position of an indole ring is achieved by tuning the reaction conditions.
ChemInform Abstract: N‐Demethylation of N‐Methyl Alkaloids with Ferrocene.
Authors: Kok Gaik B. , Scammells Peter J. 
Published: November 2010

AbstractUnder Polonovski‐type conditions ferrocene is found to be a convenient and efficient catalyst for the N‐demethylation of a number of N‐methyl alkaloids such as opiates and tropanes.
ChemInform Abstract: Formal Syntheses of Dihydrocorynantheine and Isorhynchophylline via Proline Catalyzed Mannich‐Michael Reaction.
Authors: Nagata Kazuhiro , Ishikawa Hitomi , Tanaka Ayako , Miyazaki Michiko , Kanemitsu Takuya , Itoh Takashi 
Published: November 2010

AbstractThe synthesis of alkaloid (VI) is commenced with compound (III) which is obtained by the enantioselective Mannich‐Michael reaction in the presence of (R)‐proline.
ChemInform Abstract: Kingianin A: A New Natural Pentacyclic Compound from Endiandra kingiana.
Authors: Leverrier Aurelie , Dau Marie Elise Tran Huu , Retailleau Pascal , Awang Khalijah , Gueritte Francoise , Litaudon Marc 
Published: November 2010

AbstractThe structure of the title compound (I) is determined by spectroscopic means and X‐ray analysis.
ChemInform Abstract: Secondary Metabolites Isolated from the Fungus Monascus pilosus
Authors: Cheng Ming‐Jen , Wu Ming‐Der , Chen Ih‐Sheng , Yang Ping‐Shin , Yuan Gwo‐Fang 
Published: November 2010

Abstractisolation and structure of a new pyran‐2‐one derivative, monascuspyrone (I) along with nine known compounds
ChemInform Abstract: Promomycin, a Polyether Promoting Antibiotic Production in Streptomyces spp.
Authors: Ueda Kenji , et al. et al. 
Published: November 2010

AbstractPromomycin (I), a polyether structurally related to lonomycin exhibits antibiotic activity but additionally stimulates antibiotic production in multiple Streptomyces strains at sub‐inhibitory concentrations.
ChemInform Abstract: Coelomycin, a Highly Substituted 2,6‐Dioxo‐pyrazine Fungal Metabolite Antibacterial Agent Discovered by Staphylococcus aureus Fitness Test Profiling
Authors: Singh Sheo B. , et al. et al. 
Published: November 2010

Abstractisolation, structure elucidation and biological activity of coelomycin (I)
ChemInform Abstract: Semisynthesis of Novel Monacolin J Derivatives: Hypocholesterolemic and Neuroprotective Activities.
Authors: Campoy Sonia , Sierra Saleta , Suarez Beatriz , Ramos Maria C. , Velasco Javier , Burgos Javier S. , Adrio Jose L. 
Published: November 2010

AbstractIn vitro hypocholesterolemic and neuroprotection assays show that novel monacolin J derivate NST0037 (Id) has a very low 3‐hydroxy‐3‐methylglutaryl CoA reductase IC50 and high protection rate for oxidative‐stress‐induced neuron cell death.
Scale‐down of the Jet Zone Loop Reactor: Development of a Screening Tool for Chemical Reactions
Authors: Wiedemann Mathias , Räbiger Norbert , Schlüter Michael , Eisenlauer Josef , Riener Franz‐Xaver , Kutschera Dirk , Neumann Stefan 
Published: November 2010

AbstractEine Möglichkeit zur Prozessintensivierung ist die Anwendung spezieller Hochleistungsschlaufenreaktoren. An praxisrelevanten Systemen konnte im halbtechnischen Maßstab gezeigt werden, dass die gezielte Nutzung der skalenübergreifenden Transportvorgänge zu einer signifikanten Erhöhung der Umsätze bei verschiedenen chemischen Reaktionen führt. Da der Einsatz des Strahlzonen‐Schlaufenreaktors (SZR) im halbtechnischen Maßstab mit einem hohen Aufwand verbunden ist, sollte ein Screening‐Tool im Labormaßstab zur schnellen Abschätzung der Anwendbarkeit neuer Technologien entwickelt werden. Zur Beurteilung des Scale‐down wurden hydrodynamische Studien durchgeführt.
Explosion Characteristics of Ethylene Oxide and Ethylene Oxide/Propylene Oxide Mixtures
Authors: Askar Enis , Baumeier Andreas , Holtappels Kai , Schröder Volkmar , Franzen Stefan , Büttgen Franz 
Published: November 2010

AbstractIn Gasphasen aus Ethylenoxid (EO) und Propylenoxid (PO), die bei technischen Alkoxylierungsreaktionen vorkommen, können auch ohne den Zutritt von Luft Zerfallsreaktionen stattfinden, die explosionsartig mit einer vielfachen Temperatur‐ und Drucksteigerung verlaufen. Zur Abschätzung der Auswirkungen solcher Explosionen wurden die Explosionsdrücke und die zeitlichen Druckanstiege von reinem EO und EO/PO‐Gemischen bei Temperaturen von 100 °C bis 200 °C und Drücken von 1 – 10 bar in einem 3‐dm3‐Behälter und punktuell in einem 100‐dm3‐Behälter experimentell bestimmt.
Gut–brain signalling: how lipids can trigger the gut
Authors: Breen Danna M. , Yang Clair S. , Lam Tony K. T. 
Published: November 2010

AbstractThe gut plays a unique role in the metabolic defence against energy excess and glucose imbalance. Nutrients, such as lipids, enter the small intestine and activate sensing mechanisms to maintain energy and glucose homeostasis. It is clear that a lipid‐induced gut‐brain axis exists and that cholecystokinin and a neuronal network are involved, yet the underlying mechanisms in gut lipid sensing that regulate homeostasis remain largely unknown. In parallel, studies underscore the importance of enzymes involved in lipid metabolism within the brain, such as adenosine monophosphate ‐activated protein kinase, to maintain homeostasis. In this review, we will first examine what is known regarding the mechanisms involved in this lipid‐induced gut‐brain neuronal axis that regulate food intake and hepatic glucose production. We will also discuss how enzymes that govern brain lipid metabolism could potentially reveal how lipids trigger the gut, and that both the gut and brain may share common biochemical pathways to sense lipids. Copyright © 2011 John Wiley & Sons, Ltd.
Inter‐disciplinary perspectives on processes in the hyporheic zone
Authors: Krause S. , Hannah D. M. , Fleckenstein J. H. , Heppell C. M. , Kaeser D , Pickup R. , Pinay G. , Robertson A. L. , Wood P. J. 
Published: November 2010

AbstractThe interface between groundwater and surface water within riverine/riparian ecosystems—the hyporheic zone (HZ)—is experiencing a rapid growth of research interest from a range of scientific disciplines, often with different perspectives. The majority of the multi‐disciplinary research aims to elucidate HZ process dynamics and their importance for surface water and groundwater ecohydrology and biogeochemical cycling. This paper presents a critical inter‐disciplinary review of recent advances of research centred on the HZ and highlights the current state of knowledge regarding hydrological, biogeochemical and ecohydrological process understanding. The spatial and temporal variability of surface water and groundwater exchange (hyporheic exchange flows), biogeochemical cycling and heat exchange (thermal regime) are considered in relation to both experimental measurements and modelling of these phenomena. We explore how this knowledge has helped to increase our understanding of HZ ecohydrology, and particularly its invertebrate community, the processing of organic matter, trophic cascading and ecosystem engineering by macrophytes and other organisms across a range of spatial and temporal scales. In addition to providing a detailed review of HZ functions, we present an inter‐disciplinary perspective on how to advance and integrate HZ process understanding across traditional discipline boundaries. We therefore attempt to highlight knowledge gaps and research needs within the individual disciplines and demonstrate how innovations and advances in research, made within traditional subject‐specific boundaries (e.g. hydrology, biochemistry and ecology), can be used to enhance inter‐disciplinary scientific progress by cross‐system comparisons and fostering of greater dialogue between scientific disciplines. Copyright © 2010 John Wiley & Sons, Ltd.
Lewis‐Acid‐Mediated Domino Reactions of Bis(diacetoxymethyl)‐Substituted Arenes and Heteroarenes
Authors: Clement J. Arul , Sivasakthikumaran Ramakrishnan , Mohanakrishnan Arasambattu K. , Sundaramoorthy S. , Velmurugan Devadasan 
Published: November 2010

AbstractA one‐pot synthesis of annulated heterocycles involving a Lewis‐acid‐mediated domino reaction of bis(diacetoxymethyl)‐substituted arenes and heteroarenes is described. The reaction of the tetraacetates with arenes and heteroarenes leads to the formation of 1,1‐bis‐arylated diacetates upon elimination followed by electrocyclohetero‐arylated intermediate may lead to the formation of bis‐arylated 1,1‐diacetates, which on cyclization followed by aromatization furnish annulated heterocycles.