bluuebunny/crossref_metadata_2025_split huggingface dataset:
GENDER EQUALITY DALAM PENYELESAIAN NUSYUZ PERSPEKTIF MASLAHAH DAN MUFASSIR
Authors: Irawan Wahyudi , Neli Jumni , Nur Afrizal 
Published: June 2024

This research is based on the problem of resolving Nusyuz. the term Nusyuz itself is the absence of harmony in the household caused by many factors between husband and wife. factors between husband and wife. The settlement of nusyuz settlement which is considered and accused of not promoting gender equality by feminists.by the femenism group. If the husband is worried that his wife is nusyuz, theThere are 3 stages of resolution based on the understanding of the reference Q.S An-Nisaa' verse 34 namely advising, bed separation and beating. While the wife is worried that her husband will commit nusyuz, then the solution step is based on the reference to Q.S An-Nisaa' verse 128 by making peace or giving up some of her rights in order to maintain the household. maintain the household. So this research aims to provide a comprehensive understanding understanding of the meaning and intent of the word of God related to the settlement of nusyuz. God's words related to the settlement of this nusyuz. So that the holy Qur'ran and Islam, a religion that prioritises gentleness, do not get out of line in understanding the meaning and intent of religion that prioritises gentleness is not accused of being the root of the problem of domestic violence. in this household. This research is pure literature, as The primary data source is from classical and contemporary tafsir books. The method The method used in this research is descriptive analytical method. From This research can be concluded that, first, nusyuz is on the husband and wife. wife. Both mufassirs agree to follow the steps of resolution offered by the Qur'an in sequence. by the Qur'an in sequence. Third, related to the step of hitting which is accused of gender bias by feminists mufassirs agree to provide signs if a beating occurs. All of these signs are made to maintain the absence of gender bias and the loss of women's dignity, such as the gender bias and the loss of women's dignity such as not making an impression, leave wounds, make injuries and not hitting the face. the face. the purpose of which is only for education and maintaining the sacred bond of marriage. So it can be concluded that the settlement of this nusyuz prioritises gender equality. gender equality).
Spirited Away (2001): o encontro improvável entre o capitalismo e o mundo espiritual, à luz da Corrente Marxista
Authors: Fontenele Renata Pereira , Cunha Renata Cristina da 
Published: June 2024

Este artigo visa analisar a presença dos conceitos de capitalismo e alienação em Spirited Away (2001) à medida em que os personagens do filme são transformados em trabalhadores de um mundo globalizado, entrelaçando, dessa forma, uma denúncia ao consumismo. Para isso foi necessário a utilização das lentes teóricas da Crítica Literária a fim de interpretar cenas e diálogos presentes no filme. Não obstante, coube explorar conforme a Corrente Marxista, os aspectos voltados para o consumismo desenfreado presente na obra, dando ênfase para a alienação e o capitalismo, ressaltando a forma como ambos se correlacionam dento do longa-metragem. Além disso, dentro deste trabalho pode-se discutir brevemente os pressupostos teóricos da Corrente Marxista nos conceitos essenciais de capitalismos e alienação, assim como ilustrar uma sociedade capitalista alienada no mundo espiritual do filme. Para que tais discussões fossem validadas, realizou-se uma pesquisa bibliográfica-exploratória qualitativa com base nos estudos de Suzuki (2009), Eagleton (2002), Tyson (2015), dentre outros. Conclui-se que Spirited Away (2001) destaca vários perigos do capitalismo e da alienação, nomeadamente, a desvalorização das criaturas alienadas na casa de banho, o medo de ser alienado e a sociedade capitalista.
Sala de recursos multifuncionais: documentos orientadores e a realidade de uma escola estadual do sul de Minas Gerais
Authors: Castro Aline Claudino de , Carvalho Filho Cloves Gomes de 
Published: June 2024

Para atender as especificidades dos alunos e auxiliar no processo de inclusão, nas escolas estaduais mineiras, foram implementadas as Salas de Recursos Multifuncionais (SR) de modo a assegurar um sistema educacional inclusivo e promover um Atendimento Educacional Especializado (AEE) complementar ao contraturno de escolarização do aluno. Com isso em mente e com base em um relato de experiência nesse ambiente educacional, este trabalho teve como objetivo identificar se as finalidades das SR, descritas nos documentos orientadores, são implementadas na prática no AEE dos alunos. Para isso, foram analisados o documento orientador Guia de Orientação da Educação Especial, na rede estadual de ensino de Minas Gerais (GOEE) e algumas legislações nacionais, identificando a finalidade do AEE nas SR e, posteriormente, como essas finalidades se aplicam à prática, a partir de nosso relato de experiência, no ano de 2016, em uma escola do sul de Minas Gerais. Basendo-se nos estudos realizados, identificamos, na escola em questão, algumas contradições quanto à acessibilidade de alunos cadeirantes na SR e o atendimento de reforço escolar a alunos que não são público-alvo do AEE na SR, indicando um desacordo aos documentos orientadores, que preveem a acessibilidade e autonomia dos alunos, bem como o AEE a alunos com deficiência, transtornos globais de desenvolvimento (TGD) e altas habilidades/ superdotação.
CONSCIÊNCIA CORPORAL, IMAGEM CORPORAL E CORPORALIDADE NA EDUCAÇÃO FÍSICA: UMA REVISÃO DE LITERATURA
Authors: Pereira Claudiney André Leite 
Published: June 2024

Nosso objetivo com esse estudo será fazer uma reflexão a partir de uma revisão de literatura sobre como estão presentes os conceitos de consciência corporal, imagem corporal e corporalidade na Educação Física.Com a crescente popularização das redes sociais e dos seus recursos técnicos para manipulação da imagem corporal, se faz necessário uma reflexão sobre o corpo nesse processo. Embora nas últimas décadas venha se ampliando bastante o interesse sobre a imagem corporal humana, os profissionais de Educação Física ainda são vistos pela sociedade como responsáveis pela performance do corpo, ou seja, aqueles que têm a competência de, através dos exercícios, tonificarem os músculos,promover mudanças na silhueta corporal e deixar os corpos mais saudáveis, levando em consideração que o objeto de estudo da Educação Física é a cultura corporal de movimento, diante destas questões, se faz necessário conhecer os valores da sociedade consumo presente nestas relações para uma prática mais reflexiva destes profissionais.
Knowledge, Attitude, and Willingness to Treat HIV positive Patients and Practice of Infection Control Measures and Post-exposure prophylaxis amongst dentists in Chengalpattu
Authors: Parvathy Premnath  , Mathu Sree H  , Monish Ananthan S  , Maris Manoj Kumar G  , Menaka S  , Mohamed Arsath H  
Published: June 2024

Objective: To assess the knowledge, attitude, and willingness towards the treatment of HIV-positive patients, Practice of Post-exposure prophylaxis methods, and standard infection control protocol among dentists and dental students in Chengalpattu district, Tamil Nadu, India
Materials and methods : A cross-sectional questionnaire-based study was done using Google Forms. 200 dentists and dental students in the clinical part of the dentistry program (years 4 and 5) in Chengalpattu participated in the study
Results : Amongst the 200 dentists surveyed, 88% say that they are willing to treat HIV-positive patients. Only 21% know the immediate action to be taken in case of direct blood contact with HIV positive patient (i.e.) anti-AIDS drugs such as Zidovudine should be taken. Our interpretation of Practice of infection control methods as per OSHA regulations is that 97.5% of dentists wear gloves to treat or screen all patients, 89.5% dentists use aprons/ gowns as personal protective equipment, 78.5% dentists use goggles to prevent accidental exposure to eyes, 97% dentists wash their hands after handling every patient and 85.5% dentists never bend or recap needles after use.
Conclusion : Dentists need better training on HIV post-exposure prophylaxis methods due to knowledge gaps, impacting their comfort in treating PLWHAs. This study suggests awareness campaigns and training programs to bridge this gap and improve their competence and confidence.
Is there a correlation between the changes in airway inflammation and the changes in respiratory mechanics after vaping in patients with asthma?
Authors: Kotoulas Serafeim-Chrysovalantis , Domvri Kalliopi , Tsantos Alexandros , Papagiouvanni Ioanna , Michailidou Anastasia , Spyratos Dionisios G , Porpodis Konstantinos , Grigoriou Ioanna , Papakosta Despina , Pataka Athanasia 
Published: June 2024

BACKGROUND
Electronic cigarettes (ECs) have been promoted as alternatives to traditional cigarettes.
AIM
To investigate ECs’ effects on respiratory system, especially in patients with respiratory diseases.
METHODS
We randomly selected 25 smokers with stable moderate asthma and matched them with 25 healthy smokers. All were subjucted to pulmonary function tests (PFTs), impulse oscillometry (IOS), fraction exhaled Nitric Oxide (FeNO), exhaled breathe condensate (EBC) and biomarker measurements before and after vaping one nicotine-containing EC.
RESULTS
The increase in FeNO 30 minutes after EC, reflecting airway inflammation, significantly correlated with increase of residual volume (RV), total lung capacity (TLC), respiratory impedance at 5 Hz (Z5Hz) and respiratory resistance at 5 and 20 Hz (R5Hz and R20Hz). No significant correlations were found between EBC biomarkers' changes and respiratory mechanics.
CONCLUSION
This is the first study demonstrating that the changes in airway inflammation caused by EC have direct effects in respiratory mechanics of asthmatic patients.
Patellar reconstruction in primary total knee arthroplasty using bone chips from routine cuts: A case report and review of literature
Authors: Perez-Abdala Juan Ignacio , Cicco Franco L De , Nicolino Tomas , Astoul Juan 
Published: June 2024

BACKGROUND
Total patellectomy is currently reserved for exceptional cases, such as recalcitrant patellofemoral instability and comminuted fractures, due to its demonstrated negative impact on knee biomechanics. Therefore, managing patellectomy is crucial to mitigate its inherent deleterious effects. Various techniques have been described, including autologous or allogeneic bone grafts for reconstruction and soft tissue realignment to enhance the extensor mechanism.
CASE SUMMARY
A 73-year-old male underwent a patellectomy due to a comminuted fracture, subsequently developing osteoarthritis and experiencing a decline in functional status. Concurrent with total knee replacement, we conducted a patellar reconstruction, incorporating routine bone cuts and utilizing bone chips to fashion a new patella. This intervention resulted in the restoration of full extension and improvement of knee function.
CONCLUSION
Patellar reconstruction demonstrates benefits on knee mechanics and stabilization, contributing to enhanced outcomes and satisfaction following knee replacement. We present an affordable technique for managing patellectomized patients undergoing total knee replacement.
INVESTIGATION OF CRIMINAL NEGLIGENCE AGAINST VICTIMS OF KANJURUHAN TRAGEDY
Authors: Rosmaya Ina , Tjahjadi Mochammad Rafly 
Published: June 2024

The Criminal Code does not formally define the meaning of negligence or forgetfulness. Then, the definition of negligence must be obtained from the opinions of criminal law experts and serve as a basis for defining the negligence itself. However, the Criminal Code stipulated the negligence in Article 359 and Article 360 of Criminal Code that distinguishes the result of negligence itself. Article 359 of Criminal Code explains the negligence that causes human mortality, and Article 360 of Criminal Code explains the negligence that causes serious injury to the victims. This research aims to determine the causes of Kanjuruhan Malang tragedy, who should be responsible for it, and the efforts to prevent the recurrence of the tragedy itself. This research is an empirical approach to the problem in accordance with the law that lives in society, as well as collected legal materials that are analyzed using qualitative methods, that produces descriptive information analysis. The results of this research indicate that organizing committee and the security have been negligent by making some mistakes that cause a lot of material and immaterial losses for the supporters. The organizing committee has neglected by not regulating the safety and security of the match according to PSSI regulations. Moreover, Security Officer Steward is negligent by not preparing a risk assessment document according to PSSI Regulations.
RESPON PERTUMBUHAN BIBIT KOPI (Coffea sp.) AKIBAT PEMBERIAN KOMPOS ECENG GONDOK DAN PUPUK ORGANIK CAIR FISH WASTE
Authors: Mujahidin Mujahidin , Setiawan Beny , Jatsiyah Venti , Kurniawan Tardi 
Published: June 2024

Penggunaan pupuk organik dapat memberikan dampak positif bagi lingkungn dan tanaman sehingga sangat potensial untuk digunakan dalam budidaya tanaman. Penelitian ini bertujuan untuk mengetahui adanya interaksi dan dosis yang tepat antara kombinasi kompos eceng gondok dan poc limbah ikan terhadap pertumbuhan bibit kopi (Coffea sp.) pada tanah sub soil. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) faktorial terdiri dari 9 perlakuan dan 3 ulangan. Faktor Pertama adalah kompos eceng gondok yang terdiri dari 3 taraf yaitu: K0: Tanpa Kompos Eceng Gondok K1: Kompos eceng gondok dengan dosis 50 g/tanaman K2: Kompos eceng gondok dengan dosis 75 g/tanaman. Faktor kedua adalah POC limbah ikan yang terdiri dari tiga taraf yaitu : PO: Tanpa POC Limbah organ dalam ikan P1: POC limbah organ dalam ikan konsentrasi 3 mL, P2: POC limbah organ dalam ikan konsentrasi 5 mL. Data yang diperoleh dari hasil penelitian dianalisis secara statistik dengan sidik ragam atau Analisis of Variance (ANOVA). Apabila data yang didapat berpengaruh nyata, maka dilanjutkan dengan uji Duncan Multi Range Test (DMRT) pada taraf 5%. Hasil Penelitian menunjukkan interaksi antara kombinasi kompos eceng gondok dan POC limbah ikan terjadi pada semua parameter pengamatan, pengaruh yang nyata pada semua parameter pengamatan bibit kopi diduga disebabkan oleh kinerja kedua faktor perlakuan yang saling mendukung. Dosis terbaik kombinasi kompos eceng gondok dan POC limbah ikan terhadap pertumbuhan bibit kopi terdapat pada perlakuan K2 (kompos eceng gondok 75g/tanaman) P2 (POC limbah ikan 5 ml/tanaman).
APLIKASI KOMPOS SERASAH DAUN KARET DAN PUPUK NPK TERHADAP PERTUMBUHAN BIBIT KARET (Hevea brasiliensis Muell Arg.) PADA MEDIA GAMBUT
Authors: Rahman Krisma , Fitry Ramanda Rika , Sopiana Sopiana 
Published: June 2024

Serasah daun karet berpotensi menjadi kompos sebagai alternatif baru. Penelitian bertujuan untuk mengetahui pertumbuhan bibit karet terhadap pemberian kompos serasah daun karet dan pupuk NPK di media tanah gambut, dan untuk mengetahui interaksi antara pemberian kompos serasah daun karet dan pupuk NPK. Penelitian dilaksanakan mulai April sampai Juli 2022 di Kebun Percobaan Politeknik Negeri Ketapang. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) faktorial dengan kombinasi 16 perlakuan dan 3 ulangan. Faktor pertama kompos serasah daun karet (K) terdiri dari K0 (tanpa kompos serasah daun karet), K1 (kompos serasah daun karet 250 g/polybag), K2 (kompos serasah daun karet 350 g/polybag) dan K3 (kompos serasah daun karet 450 g/polybag) dan faktor kedua pupuk NPK (M) terdiri dari M0 (tanpa NPK), M1 (NPK 1,25 g/polybag), M2 (NPK 2,5 g/polybag) dan M3 (NPK 3,75 g/polybag). Data yang diperoleh dianalisis secara statistik dengan Analysis of Variance (ANOVA). Apabila berbeda nyata, maka dilakukan uji lanjut Duncan Multiple Range Test (DMRT) pada taraf 5%. Hasil penelitian menunjukkan pemberian kompos serasah daun karet dan pupuk NPK pada media tanah gambut memberikan pengaruh nyata terhadap tinggi bibit, jumlah payung, panjang akar, berat basah bibit dan berat kering bibit. Kompos serasah daun karet 450 g/polybag dan pupuk NPK 3,75 g/polybag merupakan dosis terbaik untuk meningkatkan pertumbuhan bibit tanaman karet di media tanah gambut dengan tinggi bibit 66,53 cm, jumlah payung 7,30 helai, panjang akar 66,13 cm, berat basah bibit 50,76 g dan berat kering bibit 28,23 g.
Evaluation of maxillary sinus on anatomical characteristics and related factors using cone beam computed tomography images
Authors:   , Benjaphalakron Nutcha 
Published: June 2024

Objective: The aim of this study was to evaluate prevalence of the anatomical characteristics in maxillary sinuses; and its association with sex, age, tooth area and dental status using cone beam computed tomography (CBCT).

Methods: Retrospectively reviewed CBCT images of maxillary sinuses from 370 sinuses in 185 patients at the Faculty of Dentistry, Chulalongkorn University were evaluated. Residual ridge height (RRH), lateral wall thickness (LWT), sinus septa, posterior superior alveolar artery (PSAA), membrane thickness (MT) and ostium were evaluated and compared according to sex, age, tooth area and dental status.

Results: Mean RRH was 12.13 ± 3.64 mm. Mean LWT was 2.23 ± 0.95 mm. Prevalence of septa was 22.43%. The most orientation of the septa was mediolateral (89.13%). Septa was mostly at the first molar and second molar region (66.3%). PSAA were detected in 32.16% and most (52.85%) had an intraosseous location. The diameter was mostly 15 mm from the alveolar crest. Mean MT was 1.3 ± 2.05 mm. The ostium was mostly patency (94.05%) and located at the first molar and second molar region (95.98%). Mean distance of ostium from the sinus floor was 30.03 ± 5.08 mm.

Conclusion: Although the anatomical characteristics of maxillary sinus related to sex, age, tooth area and dental status, they also had variation. The surgeon should evaluate case by case using CBCT for planning surgery, in order to minimize the risk of complications related to sinus surgery.
Effect of erianthridin on non-small cell lung cancer cell metastasis
Authors:   , Pothongsrisit Sutthaorn 
Published: June 2024

Lung cancer is one of leading cause of deaths worldwide due to cancer metastasis. The metastatic process that initiated by dissociation of cancer cells from the primary tumor and colonization of new tumor at distant organ. Cell migration and invasion play as the key early steps and required actin reorganization and extracellular matrix (ECM) degradation to achieve cell metastasis. The inhibition of these behaviors is an intriguing approach to minimize cancer metastasis. Erianthridin, a phenolic compound isolated from the Thai orchid Dendrobium formosum exhibits several pharmacological activities; however, the effect of erianthridin on lung cancer cell metastasis has not been observed. In this study, we demonstrated that non-toxic and non-proliferative concentrations of erianthridin was able to attenuate cell migration and invasion by disruption of actin stress fibers and lamellipodia formation. The mRNA level of MMP-2 and MMP-9, the matrix-degrading protease, were significantly decreased in a dose-dependent manner after erianthridin treatment. Mechanistic investigation revealed that the active form of Akt and its downstream effectors mTOR and p70S6K were strongly suppressed in the presence of erianthridin. In addition, an in-silico study revealed that erianthridin bound directly at the ATP-bonding site of Akt with both hydrogen bonding and van der Waals interaction, resulting in dephosphorylation of Akt. This study provides preclinical information of erianthridin which exhibits a promising anti-metastasis activity against lung cancer.
Development of tetrahydrocurcumin-loaded chitosan-coated-nanostructured lipid carriers for topical treatment of psoriasis
Authors:   , Truong Hoang 
Published: June 2024

Chitosan (Ch)-coated nanostructured lipid carriers (NLCs) have great potential for topical delivery with high localization of chemotherapeutics. In this study, tetrahydrocurcumin (THC), a primary metabolite of curcumin with enhanced antioxidant and anticancer properties, was used as a model drug to prepare NLCs. Response surface methodology was employed to optimize THC-loaded Ch-coated NLCs (THC-Ch-NLCs) fabricated by high-shear homogenization. The optimized THC-Ch-NLCs had particle size of 244 ± 18 nm, zeta potential of -17.5 ± 0.5 mV, entrapment efficiency of 76.6 ± 0.2% and drug loading of 0.28 ± 0.01 mg/mL. In vitro release study of THC-Ch-NLCs showed sustained release following the Korsmeyer-Peppas model with Fickian diffusion mechanism. THC-Ch-NLCs demonstrated a significantly higher permeation through the artificial membrane than the THC-NLCs. Furthermore, THC-Ch-NLCs also exhibited cytotoxicity against TNF-α-induced HaCaT cell lines. However, the findings need further investigation to prove that the cytotoxicity is due to the encapsulation of THC in the Ch-NLC since the same effect is also observed in the blank lipid-nanoparticles.
Development of Hek-293t cells stably expressing the c-x-c chemokine receptor type 4 (cxcr4) for binding assay of potential anti-breast cancer agents
Authors:   , Dinh Thi 
Published: June 2024

The C-X-C chemokine receptor type 4 (CXCR4) has been recognized as a potential target in cancer drug discovery based on the high expression in cancer cells, particularly invasive breast cancer. This study aims to construct CXCR4-overexpressed cells to screen new anti-breast cancer agents targeting CXCR4 and identify the mediated target for anticancer effect. Firstly, five genetic isotypes of CXCR4, namely A, B, C, D and E, were amplified from Jurkat T cells. Amplicons of each CXCR4 isotype were ligated into cloning vectors and subcloned into expression vectors. They were transformed into competent Escherichia coli strain DH5-alpha cells. The presence of CXCR4 plasmids in the selective transformed cells was determined by colony PCR and gel electrophoresis. The recombinant plasmids of CXCR4-isotype B were selected for stable transfection in HEK293T cells. CXCR4 expression was confirmed by flow cytometry and the population of the highly CXCR4 expressing cells was isolated using the fluorescence-activated sorting cells technique to obtain 99.8% of CXCR4-expressing cells. The CXCR4-overexpressed HEK293T cells were verified by conducting the competitive binding assay of a known CXCR4 inhibitor, AMD3100 (plerixafor), using monoclonal anti-human CD184 (CXCR4) antibody tagged with fluorescence probe, phycoerythrin. The obtained IC50 of plerixafor (305.5 nM) against the binding of the antibody to CXCR4 was in accordance with those determined by conventional competitive radioligand binding assay. Moreover, the developed CXCR4-overexpressed HEK293T cells were used in the competitive binding assay to identify the mediated target of natural compounds showing high cytotoxicity against the invasive breast cancer cell line MDA-MB-231. The tested compounds were extracted from Stephania pierrei, which were methoxy-8-uvariopsine, crebanine and dehydrocrebanine. However, the application of the fluorescence tagged antibody competition binding assay to determine the binding affinity of these potential compounds has been limited due to the poor solubility of natural compounds, which required additional solvent and surfactant to improve the solubility leading to high fluorescence quenching. Further development of low fluorescence quenching solvent and solubilizer is needed to implement this assay in the screening platform.