bluuebunny/crossref_metadata_2025_split huggingface dataset:
The successful management of two pregnancies with wild type metastatic gastrointestinal stromal tumors
Authors: TAN Thean Hsiang , HEMMINGS Christine , STAFFORD‐BELL Martyn , ROBSON Steve , GOLDSTEIN David , YIP Desmond 
Published: September 2009

AbstractAim:  To discuss the management of the uncommon situation of metastatic gastrointestinal tumour coexisting with pregnancy.Method:  We describe two cases of women with metastatic gastrointestinal stromal tumor (GIST) who successfully achieved a full‐term pregnancy without complications and with the delivery of healthy infants. In both cases, treatment with imatinib mesylate was withheld during pregnancy because of its unknown effects and questionable safety for the developing fetus. The available data in the medical literature regarding the use and safety of imatinib and pregnancy are reviewed. We also examine whether the knowledge of the exon mutational status would have influenced treatment decisions.Results:  Both women had wild type GIST, but with different tumor growth characteristics, treatment responses and outcomes. The first patient deferred imatinib therapy to fall pregnant and her disease progressed rapidly off treatment. The second patient had a more indolent GIST where active surgical management allowed her to experience a long durable clinical response. She potentially belongs to a pediatric subgroup which carries a better prognosis despite being off imatinib.Conclusion:  While we have successfully managed two pregnant women with metastatic GIST, the issue of initiating imatinib therapy in treatment‐naive women, and treatment interruption in women already on therapy, remain difficult areas. Patients and their partners need to make an informed choice regarding the associated risks and the potential long‐term sequelae if pregnancies are contemplated. Further research into the natural history of wild type GIST and how to tailor subsequent treatment are needed.
Reversible encephalopathy following 5‐fluorouracil‐based chemotherapy in patients with dihydropyrimidine dehyrogenase deficiency
Authors: KIM Dong Wook , OH Jeeyoung , CHO Yo Han , KIM So Young , YOON So Young 
Published: September 2009

Abstract5‐fluorouracil (5‐FU) is one of the most frequently used chemotherapy agents for the treatment of a number of solid cancers. We report two patients with advanced gastric cancer who developed acute encephalopathy after receiving chemotherapy composed of 5‐FU and oxaliplatin. One patient presented with altered consciousness and the other with generalized tonic clonic seizure. 5‐FU‐induced encephalopathy was suspected by clinical, radiological and electroencephalographic findings, and both patients had reduced expression of dihyropyrimidine dehydrogenase, the rate‐limiting enzyme responsible for the catabolism of 5‐FU. The neurological symptoms improved spontaneously, and did not recur in the following cycle of chemotherapy with the administration of a reduced dose of 5‐FU. We suggest that the early recognition of this adverse event can reverse 5‐FU‐induced neurological symptoms and a dose reduction of the offending drug can prevent the recurrence of 5‐FU induced encephalopathy.
On fitting planetary systems in counter-revolving configurations
Authors: Gayon-Markt Julie , Bois Eric 
Published: September 2009

Abstract
In Gayon & Bois and Gayon, Bois & Scholl, (i) we studied the theoretical feasibility and efficiency of retrograde mean motion resonances (i.e. two planets are both in orbital resonance and in counter-revolving configuration), (ii) we showed that retrograde resonances can generate interesting mechanisms of stability and (iii) we obtained a dynamical fit involving a counter-revolving configuration that is consistent with the observations of the HD 73526 planetary system. In the present Letter, we present and analyse data reductions assuming counter-revolving configurations for eight compact multiplanetary systems detected through the radial velocity method. In each case, we select the best fit leading to a dynamically stable solution. The resulting data reductions obtained in rms and values for counter-revolving configurations are of the same order, and sometimes slightly better than for prograde configurations. In the end, these fits tend to show that, over the eight studied multiplanetary systems, six of them could be regulated by a mechanism involving a counter-revolving configuration.
VISUAL CHARACTERIZATION OF THE ESTHETIC QUALITY OF THE ROSEBUSH
Authors: BOUMAZA RACHID , DEMOTES‐MAINARD SABINE , HUCHE‐THELIER LYDIE , GUERIN VINCENT 
Published: September 2009

ABSTRACT Since its introduction into the analysis of foodstuffs, sensory analysis has been applied in several contexts. This work seeks to widen the field of sensory analysis to include ornamental plants and to characterize their esthetic quality. Using the rosebush as a plant model, an attribute generation protocol is proposed in order to develop a conventional profile of such products. Further to statistical treatments aiming to verify the unambiguity, discrimination and independence of these attributes, a reduced list of 18 attributes has been set up. These attributes make up the very core of the conventional profiling studies currently undertaken.PRACTICAL APPLICATIONSThe generation of a list of attributes that is not too long, in order to describe plants as exhaustively as possible, is one of the first steps of extending sensory analysis methods to ornamental horticulture. This list will be used to train a panel of assessors to characterize the rosebush.Two applications are in progress. The first application consists of evaluating the impact of nitrogen nutrition on the visual quality of the rosebush. The second has the objective of determining which characteristics influence consumer preferences.
FOOD FOR THOUGHT: SOCIAL VERSUS ENVIRONMENTAL SUSTAINABILITY PRACTICES AND PERFORMANCE OUTCOMES
Authors: PULLMAN MADELEINE E. , MALONI MICHAEL J. , CARTER CRAIG R. 
Published: September 2009

ABSTRACTSustainable supply management research generally focuses on environmental practices. We show through an analysis of the food industry that sustainability requires an expanded view to encompass both environmental and social elements. We interviewed and surveyed food and beverage producers in the U.S. Pacific Northwest to both validate expanded sustainability elements in the industry and assess subsequent performance outcomes. A path analysis reveals that food industry managers perceive both direct and mediated impacts of sustainability programs on performance. Specifically, the results indicate that sustainability program effects are limited to the impact of conservation and land management environmental practices on overall environmental performance and human resources practices on quality performance. However, environmental performance improvements lead to improved quality performance, which in turn improves cost performance. The results highlight the complexity of sustainability impacts on performance and suggest that performance benefits from sustainability programs may be difficult to recognize.
Effect of Shear on the Rheology and Crystallization of Palm Oil
Authors: Tarabukina E. , Jego F. , Haudin J.‐M. , Navard P. , Peuvrel‐Disdier E. 
Published: September 2009

ABSTRACT:  This article reports on the impact of shear on crystallization upon cooling of palm oil. Samples were cooled down under shear from 70 to 10 °C, then kept at this temperature, while performing rheological measurements using a controlled shear rate rheometer and rheo‐optical observations using optical microscopy and small‐angle light scattering. Shear rates between 1 and 300 s−1 were investigated. Two crystallization steps were observed, characterized by associated viscosity increases. The effect of shear on these 2 crystallization processes was investigated. Shear was shown to influence almost all of the steps of the structuring process of the crystallizing palm oil. The spherulite size and growth rate during the 1st crystallization are affected by shear. The onset time of the 2nd crystallization process strongly depends on the extent of shear. The steady state structures after the 1st and 2nd crystallization processes constituted of a suspension of aggregates of spherulites are controlled by the applied shear rate.Practical Application: The texture of crystallized vegetal fats and subsequent end product properties depend on the structure developed during the crystallization process. This structuring process is strongly influenced by the thermo‐mechanical history applied to the product (cooling rate, degree of undercooling, annealing time, application of flow). This article shows how the shear rate as well as extent of shear affects the different steps of the crystallization and aggregation processes in the case of palm oil after the 1st crystallization.
Influence of gender and menopausal status on peripheral and choroidal circulation
Authors: Kavroulaki Dimitra , Gugleta Konstantin , Kochkorov Asan , Katamay Robert , Flammer Josef , Orgul Selim 
Published: September 2009

Acta Ophthalmol. 2010: 88: 850–853Abstract.Purpose:  To evaluate the influence of menopausal status and age on peripheral and ocular circulation assessed by means of continuous laser Doppler flowmetry (LDF).Methods:  Fifty‐three healthy participants were recruited randomly. Twenty‐six men and 27 women were divided into two age groups. Choroidal blood flow was measured by LDF and peripheral circulation was measured at the fingertips (digit IV) using the Perimed PeriFlux (Järfälla, Sweden) laser Doppler System 5000. Independent t‐test and two‐way analysis of variance (anova) were performed.Results:  Group distribution was: male/female = 14/16 for the younger group and 12/11 for the older group. Average age across groups was 31.3 ± 6.8/28.4 ± 7.0 years and 66.3 ± 8.3/61.5 ± 3.6 years, respectively. Finger and choroidal LDF flow values were significantly different between the two female age groups (p < 0.001 and p = 0.03, respectively). In men this was not the case (p = 0.85 and p = 0.56, respectively). anova interaction p‐value for the factors ‘age group’ and ‘gender’ for finger LDF flow was p = 0.012, and for choroidal LDF flow p = 0.049, demonstrating significant gender differences with ageing.Conclusion:  Menopausal status in women has significant influence on both choroidal and peripheral blood flow; the opposite behaviour occurs with ageing.
Morphological evaluation of normal human corneal epithelium
Authors: Ehlers Niels , Heegaard Steffen , Hjortdal Jesper , Ivarsen Anders , Nielsen Kim , Prause Jan Ulrik 
Published: September 2009

Acta Ophthalmol. 2010: 88: 858–861Abstract.Purpose:  The human corneal epithelium is usually described as a 50‐μm‐thick layer of regular stratified squamous non‐keratinized cells with a thickness of 5–7 cells. The purpose of this study is systemically to revisit the histopathological appearance of 100 corneas.Methods:  5‐μm‐thick sections of corneas from 100 consecutively selected paraffin‐embedded eyes were stained with hematoxylin–eosin and Periodic Acid‐Schiff (PAS). All specimens were evaluated by light microscopy. The eyes were enucleated from patients with choroidal melanoma. Corneas were considered to be normal.Results:  Ninety of 100 eyes were evaluated. The central epithelial, stromal and total corneal thickness was measured as 36.0 μm, 618 μm and 651 μm, respectively, with a variation coefficient from 0.21 to 0.22. Pathological appearances were found in 27% of corneas, including thickened basement membrane and alterations in Bowman’s membrane. No intraepithelial microcysts, as found in Meesmann corneal dystrophy, were observed.Conclusion:  The total corneal thickness was higher than reported in in vivo studies and with a wider variation. This may be an effect of uncontrolled swelling and dehydration during preparation. The high number of pathological observations suggests that ‘normal’ eyes harbour and potentially accumulate considerable pathology.
Association of increased serum acute‐phase protein concentrations with reproductive performance in dairy cows with postpartum metritis
Authors: Chan Jacky Peng‐Wen , Chang Chao‐Chin , Hsu Wei‐Li , Liu Wen‐Bor , Chen Ter‐Hsin 
Published: September 2009

Background:It is known that quantification of bovine acute‐phase proteins could routinely provide early diagnostic and prognostic information for monitoring herd health status.Objective:The aim of this study was to test the hypothesis that haptoglobin (Hp) and serum amyloid A (SAA) have the potential for indicating uterine infection, mainly due to subclinical endometritis, which can seriously influence the reproductive performance in dairy cows.Methods:A total of 264 serum samples were collected from 24 Holstein dairy cows at defined intervals from 1 week prepartum to 6 months postpartum. Clinically healthy animals (Group 1,n=6) were compared with 24 animals having acute puerperal metritis (Group 2,n=18) and with concentrations obtained from healthy heifers (baseline values,n=10). The concentrations of serum Hp and SAA were measured using a hemoglobin‐binding assay and Western blot analysis, respectively. Reproductive performance was assessed as the number of days open and the conception rate at the end of the study.Results:Upper cut‐off values for Hp and SAA concentrations in heifers were 130.9 μg/L and 51.9 μg/mL, respectively. Hp concentrations in Group 2 were significantly higher than those in Group 1 at all time points (P<.001). Additionally, among the successfully pregnant animals, the number of days open was significantly higher in 6 cows with Hp >130.9 μg/mL (median=316 days) than in 11 cows with Hp ≤130.9 μg/mL (median=120 days) (P=.0024).Conclusions:Serum Hp and SAA concentrations can be used to recognize uterine infection in postpartum cows. The association between elevated Hp values and number of days open suggests Hp may also be a useful indicator of poor prognosis for reproductive performance.
Gold Run tephra: a Middle Pleistocene stratigraphic and paleoenvironmental marker across west-central Yukon Territory, Canada
Authors: Westgate J. A. , Preece S. J. , Froese D. G. , Telka A. M. , Storer J. E. , Pearce N. J.G. , Enkin R. J. , Jackson L. E. , LeBarge W. , Perkins W. T. 
Published: September 2009

Gold Run tephra has been found at Thistle Creek, Sixtymile River, and the Klondike goldfields of west-central Yukon, Canada. It is a hornblende-bearing rhyolitic tephra with thicknesses of up to 10 cm at each site, suggesting a widespread distribution across interior Alaska and the Yukon Territory, given the long distance to the nearest volcanic centre. Old Crow, Flat Creek, and TA tephra beds are stratigraphically associated with Gold Run tephra at our study sites and have distinctive compositions. Gold Run tephra is not accommodated by the current classification scheme for late Cenozoic distal tephra beds in Alaska and the Yukon Territory — a scheme based on the physical and chemical attributes — so that its provenance is unknown. An early-Middle Pleistocene age is supported by a glass fission-track age of 0.74 ± 0.06 Ma, a normal remanent magnetic polarity for the enclosing loess, and the presence of a late Irvingtonian faunal assemblage in the associated organic-rich silts at Thistle Creek. Hence, Gold Run tephra was deposited during the very early part of the Brunhes Chron, at which time a shrub tundra environment prevailed across west-central Yukon.
Unnatural random mating policies select for younger age at maturity in hatchery Chinook salmon (Oncorhynchus tshawytscha) populations
Authors: Hankin David G. , Fitzgibbons Jacqueline , Chen Yaming 
Published: September 2009

We explored the long-term consequences of three mating regimes ((1) completely random, (2) completely random but excluding jacks (age 2 males), and (3) male length ≥ female length) on age and sex structure of wild and hatchery populations of Chinook salmon ( Oncorhynchus tshawytscha ). Regimes similar to regimes 1 or 2 are used at most salmon hatcheries, whereas regime 3 emulates the outcomes of natural spawning behaviors that favor larger males. Inheritance of age at maturity is captured in age- and sex-structured models via matrices of age- and sex-specific conditional maturation probabilities that depend on age and sex of parents. In unexploited populations, regime 1 leads to substantial long-term selection for younger age at maturity, an effect that is somewhat reduced by regime 2, but greatly reduced under regime 3. Equilibrium age and sex structures for wild and hatchery populations under regime 3 are similar to those of natural populations, whereas mating regime 1 generates age structure that is greatly shifted toward younger ages and jacks. To prevent unintentional selection for younger age at maturity, we recommend that large-scale hatcheries replace unnatural completely random mating regimes with mating regimes that emulate the outcomes of natural spawning behaviors.
Effects of temperature change on demersal fishes in the California Current: a bioenergetics approach
Authors: Harvey Chris J. 
Published: September 2009

Diverse fish assemblages should feature a range of biological and ecological responses to temperature change. Using preliminary bioenergetics models, I simulated growth and maturation of three California Current groundfish (yelloweye rockfish ( Sebastes ruberrimus ), sablefish ( Anoplopoma fimbria ), and spiny dogfish ( Squalus acanthias )) at fixed temperatures ranging from 5 °C to 11 °C. I examined three response variables (size at age 1 (W1), age at 50% maturity (τ50%), and total prey consumption (C)). Yelloweye rockfish responded most strongly for W1, which increased 496% as temperature increased from 5 °C to 11 °C. Spiny dogfish τ50%was highly sensitive, declining from >48 years at 5 °C to <13 years at 11 °C. Age-specific C was most responsive in yelloweye rockfish, increasing by more than fivefold over the range of temperatures, although sablefish likely have greater community-wide impact because their trophic level and absolute feeding rates are higher. Regime shifts, temperature anomalies, or global climate change may directly affect fish energy budgets, elicit range shifts, or produce complex ecological interactions. Studies like this will help managers to identify temperature-sensitive species and anticipate potential changes in populations and diverse communities.
Seasonal dispersion of Pacific halibut (Hippoglossus stenolepis) summering off British Columbia and the US Pacific Northwest evaluated via satellite archival tagging
Authors: Loher Timothy , Blood Calvin L. 
Published: September 2009

Fisheries for eastern Pacific halibut ( Hippoglossus stenolepis ) occur over a 9-month season that is closed in winter to protect spawners. The industry has requested season extension, but conventional tag data suggest that 67% of Canada’s fishable biomass may comprise Alaskan spawning stock vulnerable to out-of-area interception. Seventy-eight halibut were tagged during summer in Canada and the US Pacific Northwest (USPNW) with archival tags programmed to report via satellite on 1 February, 15 February, and 1 March. Fifty-seven tags (44 Canadian and 13 USPNW) escaped recapture and reported on or near their scheduled reporting dates. Only 7% out-of-area dispersion was observed for Canadian-tagged halibut; light-based geolocations suggested that an additional 4% may have emigrated prior to February and then returned. Halibut that emigrated were located north of their tagging location. From the USPNW, 46% dispersion was observed. Eighty-nine percent of the tagged halibut displayed depth profiles consistent with migration to offshore spawning areas during the winter, and the majority (78%) were located on the continental slope (>200 m) immediately prior to tag reporting, suggesting locations on or near spawning grounds. There was no detectable difference in dispersion by date, but the mean central position of Canadian-tagged halibut shifted progressively farther southeast over time.
High-resolution infrared spectra of H2–Ne and D2–Ne van der Waals complexes This article is part of a Special Issue on Spectroscopy at the University of New Brunswick in honour of Colan Linton and Ron Lees.
Authors: McKellar A. R.W. 
Published: September 2009

Spectra of weakly bound hydrogen–neon complexes have been studied in equilibrium gas mixtures at relatively high spectral resolution (0.05–0.12 cm–1) using a long-path (112 m), low-temperature (24 K) absorption cell and a Fourier transform infrared spectrometer. Most of the data cover the region of the H2 or D2 fundamental stretching vibrations in the mid-infrared (λ ∼2.4 or 3.3 μm), but results on the pure rotational S0 (0) band of D2–Ne in the far-infrared (λ ∼55 μm) are also included. The spectra are greatly improved compared to the only previous observation. The results serve as a stringent experimental constraint for testing and improving theoretical determinations of the potential-energy surface, which describes the intermolecular forces for the hydrogen–neon system.
Rotational transitions within the 21, 31, 41, and 61 states of formaldehyde H212C16O This article is part of a Special Issue on Spectroscopy at the University of New Brunswick in honour of Colan Linton and Ron Lees.
Authors: Margulès L. , Perrin A. , Janečkovà R. , Bailleux S. , Endres C. P. , Giesen T. F. , Schlemmer S. 
Published: September 2009

This work, besides its fundamental interest, is motivated by the atmospheric and astrophysical importance of formaldehyde (H2CO). The goal of this study is to complete the already existing list of rotational transitions within the ground vibration state by a list of transitions within the four first excited 21, 31, 41, and 61 vibrational states, to help the detection of this species by microwave or millimetre wave techniques. For this purpose, the rotational spectra of H2CO in the 21, 31, 41, and 61 excited vibrational states have been investigated in Lille and Cologne in the millimetre region at 160–600 GHz and 850–903 GHz, respectively. The results of these millimetre wave measurements were combined with the 21, 31, 41, and 61 infrared energy levels, which were obtained from previous analysis of FTS spectra of the ν4 (out of plane bending mode), ν6 (CH2 rock mode), and ν3 (CH2 bending mode) bands recorded in the 10 µm region (D.C. Reuter, S. Nadler, S.J. Daunt, and J.W.C. Johns. J. Chem. Phys. 91, 646 (1989)) and more recently for the ν2 fundamental band (C=O stretching, located at 1746.009 cm–1) (F. Kwabia Tchana, A. Perrin, and N. Lacome. J. Mol. Spectrosc. 245, 141, (2007)). The energy level calculation of the 21, 31, 41, and 61 interacting states accounts for the various Coriolis-type resonances that perturb the energy levels of the 21, 31, 41, and 61 vibrational states as well as for the anharmonic resonances coupling the 21 and 31 energy levels, and in this way the microwave and infrared data could be reproduced within their associated experimental uncertainty. However, it is clear that the theoretical model used to account for the very large A-type Coriolis resonance linking the 41 and 61 energy levels of H2CO is only effective with poor physical meaning.