bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of trademark intensity on firm performance: Unraveling the role of product market competition, total factor productivity, and SG&A efficiency
Authors: Patel Pankaj C. 
Published: May 2024

AbstractUsing the market‐based‐view of the firm, this study investigates the relationship between trademark intensity and firm performance under the conditions of product market competition, total factor productivity, and SG&A efficiency. Higher trademark intensity is more positively associated with performance, and this positive association is amplified under higher product market competition or weakened under higher SG&A efficiency or total factor productivity. To address potential endogeneity, we employ partialing out lasso regression and cross‐fit partialing out lasso regression techniques, which yield consistent results. The findings provide valuable insights into the interplay between trademark intensity and firm performance.
Continuous Levodopa Delivery with an Intraoral Micropump System: An Open‐Label Pharmacokinetics and Clinical Study
Authors: Olanow C. Warren , McIntyre Deborah , Matarazzo Michele , Leinonen Mika , McGarry Andrew , Kamp Cornelia , Kennedy Julie , Torti Margherita , Kruger Rejko , Obeso José A. , Stocchi Fabrizio , Heller Ephraim , Kieburtz Karl 
Published: May 2024

AbstractBackgroundDouble‐blind studies have demonstrated that motor complications in Parkinson's disease (PD) can be reduced with continuous delivery of levodopa. The DopaFuse system is a novel, intraoral micropump that attaches to a retainer and uses a propellant to deliver levodopa/carbidopa (LD/CD) continuously into the mouth.ObjectivesEvaluate the safety, pharmacokinetics, and efficacy of LD/CD delivered via the DopaFuse system compared to treatment with intermittent doses of standard oral LD/CD in PD patients with motor fluctuations.MethodsThis was a 2‐week, open‐label study (NCT04778176) in 16 PD patients treated with ≥4 levodopa doses/day and experiencing motor fluctuations. On Day 1 (clinic setting) patients received their usual dose of standard LD/CD; DopaFuse therapy was initiated on Day 2, and on Day 3 patients received DopaFuse plus a morning oral LD/CD dose. Patients returned home on Days 4–14 and returned for in‐clinic assessment on Day 15.ResultsContinuous DopaFuse delivery of LD/CD was associated with reduced variability in plasma levodopa levels compared to oral LD/CD (mean ± SD levodopa Fluctuation Index reduced from 2.15 ± 0.59 on Day1 to 1.50 ± 0.55 on Day 2 (P = 0.0129) and to 1.03 ± 0.53 on Day 3 (P < 0.0001)). This pharmacokinetic improvement translated into significantly reduced OFF time with DopaFuse therapy (reduction of −1.72 ± 0.37 h at Day 15; P = 0.0004) and increased ON time without severe dyskinesias (increase of 1.72 ± 0.37 h at Day 15; P = 0.0004) versus oral LD/CD administration. DopaFuse therapy was not associated with any clinically significant adverse events.ConclusionsContinuous delivery of LD/CD using the DopaFuse system was associated with significantly less variability in plasma levodopa concentrations and reductions in OFF time compared to treatment with standard oral LD/CD therapy and was well tolerated. © 2024 International Parkinson and Movement Disorder Society.
Whole‐body magnetic resonance neurography in patients with chronic inflammatory demyelinating polyneuropathy
Authors: Fathi Davood , Naraghi Ali , White Lawrence M. , Dodig Dubravka , Barnett‐Tapia Carolina , Breiner Ari , Bril Vera , Katzberg Hans D. 
Published: May 2024

AbstractIntroduction/AimsWhole‐body magnetic resonance neurography (MRN) is an imaging modality that shows peripheral nerve signal change in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). We aimed to explore the diagnostic potential of whole‐body MRN and its potential as a monitoring tool after immunotherapy in treatment‐naïve CIDP patients.MethodsWhole‐body MRN using coronal 3‐dimensional short tau inversion recovery (STIR) sampling perfection with application‐optimized contrasts by using different flip angle evolution (SPACE) techniques was performed in patients being investigated for CIDP and in healthy controls. Baseline clinical neuropathy scales and electrophysiologic parameters were collected, and MRN findings were compared before and after CIDP treatment.ResultsWe found highly concordant symmetrical thickening and increased T2 signal intensities in the brachial/lumbosacral plexus, femoral, or sciatic nerves in five of the eight patients with a final diagnosis of CIDP and none of the healthy controls. There were no treatment‐related imaging changes in five patients with CIDP who completed a follow‐up study. Diffuse, symmetrical thickening, and increased T2 signal in root, plexus, and peripheral nerves were found in two patients ultimately excluded due to a diagnosis of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes (POEMS) syndrome in addition to signal changes in the muscles, bony lesions, organomegaly, and lymphadenopathy.DiscussionWhole‐body MRN imaging shows promise in detecting abnormalities in proximal nerve segments in patients with CIDP. Future studies evaluating the role of MRN in assessing treatment response should consider follow‐up scans after treatment durations of more than 4 months.
Organizing logic multiplicity in hybrid organizations: The role of organizational culture
Authors: Pinz Alexander , Englert Benedikt , Helmig Bernd 
Published: May 2024

AbstractHybrid organizations must deal with institutional complexity and find ways to manage conflicting demands in their organizational environment to engage in their required, day‐to‐day activities. The objective of this qualitative research is to elaborate on the mechanisms that hybrid organizations use to mitigate the destabilizing effects of such institutional logic multiplicity in their value creation processes. By combining value configuration analyses and the hybrid organizing concept as a theoretical background, the authors conduct a case study with 14 nonprofit microfinance organizations (MFOs) that illustrates the importance of an integrative organizational culture as a core foundation that can align and integrate social and economic demands. Successful nonprofit MFOs align competing institutional logics in a hierarchy of goals, explicitly defining their means and objectives. Independent of the type of logic multiplicity they face, they use the hierarchy to define their organizational identity and transfer it to a corresponding organizational culture that can balance diverse institutional demands. From a theoretical perspective, this study advances institutional logic approaches; it also identifies effective mechanisms hybrid organizations can use to cope with logic multiplicity by applying a value configuration perspective.
A review of the emerging approaches for developing multi‐scale filler‐reinforced epoxy nanocomposites with enhanced impact performance
Authors: Shelly Daksh , Singhal Varun , Nanda Tarun , Mehta Rajeev , Aepuru Radhamanohar , Lee Seul‐Yi , Park Soo‐Jin 
Published: May 2024

AbstractFiber‐reinforced polymer composites (FRPCs) are utilized for myriad applications owing to their exceptional characteristics like high specific strength and stiffness. However, the low‐to‐moderate impact strength of these materials is a major constraint restricting their usage in fields requiring high‐impact performance. To ensure the reliable performance of FRPCs throughout the intended life span, a combination of good static mechanical properties and high impact resistance is crucial. Recent advancements in this field have yielded a breakthrough by developing novel materials that overcome this limitation. This groundbreaking achievement was realized by processing epoxy‐based GFRPs containing a synergistic blend of surface‐modified nano‐clay and compatibilized polymeric fiber micro‐reinforcement. This review provides an overview of advancements in the development of FRPCs, starting from the single‐filler to multi‐scale filler‐reinforced materials. The review elaborates on the effect of reinforcement of various thermoplastic fibers (polyethylene, para‐aramid, and spandex) on the mechanical performance of FRPCs. The necessity of filler compatibilization to enhance interfacial bonding constituents is also discussed. It can be concluded that the choice of surface treatment for a given thermoplastic fiber is governed by its chemical composition, the functional groups to be added on its surface through a specific compatibilization treatment, and the chemical nature of other constituents of the composite system with which the treated fiber surface interacts. Further, the greater the elasticity and ductility of the reinforced thermoplastic fiber, the higher the impact strength of the resulting epoxy‐based GFRPs. Finally, the review brings forth the potential opportunities for future research in this area.Highlights
Discussed recent advancements in epoxy‐based GFRPs with multi‐scale filler reinforcement.
Multi‐scale filler‐reinforced epoxy‐based GFRPs have myriad applications in aviation, automobile, marine, sports, etc.
Nano‐/micro‐fillers in their pristine state degrade the mechanical performance of epoxy‐based GFRPs.
Filler compatibilization is essential for achieving superior mechanical performance in epoxy‐based GFRPs.
Reinforcing compatibilized soft/ductile thermoplastic fibers resulted in a notable increase in impact strength while maintaining tensile properties.
Characterization of effective, simple, and low‐cost precipitation methods for depleting abundant plasma proteins to enhance the depth and breadth of plasma proteomics
Authors: Rice Shawn J. , Belani Chandra P. 
Published: May 2024

AbstractPlasma is an abundant source of proteins and potential biomarkers to aid in the detection, diagnosis, and prognosis of human diseases. These proteins are often present at low levels in the blood and difficult to identify and measure due to the large dynamic range of proteins. The goal of this work was to characterize and compare various protein precipitation methods related to how they affect the depth and breadth of plasma proteomic studies. Abundant protein precipitation with perchloric acid (PerCA) can increase protein identifications and depth of plasma proteomic studies. Three acid‐ and four solvent‐based precipitation methods were evaluated. All methods tested provided excellent plasma proteomic coverage (>600 identified protein groups) and detected protein in the low pg/mL range. Functional enrichment analysis revealed subtle differences within and larger changes between the precipitant groups. Methanol‐based precipitation outperformed the other methods based on identifications and reproducibility. The methods’ performance was verified using eight lung cancer patient samples, where >700 protein groups were measured and proteins with an estimated plasma concentration of ∼10 pg/mL were detected. Various protein precipitation agents are amenable to extending the depth and breadth of plasma proteomes. These data can guide investigators to implement inexpensive, high‐throughput methods for their plasma proteomic workflows.
Electron ionization mass spectrometry feature peak relationships combined with deep classification model to assist similarity algorithm for fast and accurate identification of compounds
Authors: Zhang Jiajiang , Li Junhui , Ding Binbin , Qiao Qusheng , Wang Haixing , Liang Yanchao , Song Peihong , Wu Yong , Wang Chenlu , Tang Keqi , Yu Jiancheng 
Published: May 2024

RationaleGas chromatography–mass spectrometry (GC–MS) combines chromatography and MS, providing full play to the advantages of high separation efficiency of GC, strong qualitative ability of MS, and high sensitivity of detector. In GC–MS data processing, determining the experimental compounds is one of the most important analytical steps, which is usually realized by one‐to‐one similarity calculations between the experimental mass spectrum and the standard mass spectrum library. Although the accuracy of the algorithm has been improved in recent years, it is still difficult to distinguish structurally similar mass spectra, especially isomers. At the same time, the library capacity is very large and increasing every year, and the algorithm needs to perform large numbers of calculations with irrelevant compounds in the library to recognize unknown compounds, which leads to a significant reduction in efficiency.MethodsThis work proposed to exclude a large number of irrelevant mass spectra by presearching, perform preliminary similarity calculations using similarity algorithms, and finally improve the accuracy of similarity calculations using deep classification models. The replica library of NIST17 is used as the query data, and the master library is used as the reference database.ResultsCompared with the traditional recognition algorithm, the preprocessing algorithm has reduced the time by 4.2 h, and by adding the deep learning models 1 and 2 as the final determination, the recognition accuracy has been improved by 1.9% and 6.5%, respectively, based on the original algorithm.ConclusionsThis method improves the recognition efficiency compared to conventional algorithms and at the same time has better recognition accuracy for structurally similar mass spectra and isomers.
Proof of concept evidence that stable isotopes of carbon, nitrogen and sulphur may identify individual kittiwakes breeding in different colonies
Authors: Furness Robert W. , Furness Euan N. 
Published: May 2024

RationaleCarbon, nitrogen and sulphur stable isotopes in feathers grown by seabirds while breeding reflect the local isoscape and diet in the vicinity of the colony, so may make it possible to discriminate individual birds from different colonies.MethodsBlack‐legged kittiwake Rissa tridactyla inner primary feathers from two colonies about 350 km apart in the North Sea were used to test whether δ13C, δ15N and δ34S differed between individuals from the two colonies. Feather tips cut from breeding birds caught at nests were compared with tips of moulted feathers (grown 1 year earlier) found on the ground.ResultsIsotopic compositions showed no overlap between the two colonies in δ13C, δ15N or δ34S in tips of newly‐grown feathers sampled from breeding adult kittiwakes. There was some overlap in δ13C, δ15N and δ34S from moulted feathers, but discriminant analysis allowed >90% of individuals to be assigned to their colony. In five of six comparisons, mean isotopic compositions were the same in new and moulted feathers but not for δ34S at one of the two colonies.ConclusionsThis study has demonstrated for the first time that stable isotopes in inner primary feathers of kittiwakes can allow accurate identification of the breeding colony of individual birds from two different colonies within the North Sea. Further research is required to determine if this method can be applied with greater spatial resolution and to a larger number of colonies.
Sexuality in the era of transhumanism: A point of view
Authors: Arias‐Castillo Liliana , González‐Arboleda Andrés Augusto , García‐Perdomo Herney Andrés 
Published: May 2024

AbstractSeveral technological and scientific developments have arisen to enhance the human condition. Transhumanism is an intellectual movement that gathers different knowledge sectors to attain a physical and psychological fullness state, with capacities that surpass a human as is known today. These advances have led to a remarkable development in human–robot interaction, an interaction science that studies how technology could influence human behavior. Social robots are part of this science, looking to improve the interaction between robots and the general population in everyday contexts. Sex robots, being part of social robots, have gained a lot of importance in the industry. But, does any relationship exist between transhumanism and sexuality? Some authors have proposed beneficial sex robots in sexual dysfunctions and older adults. However, several contradictors state that sex robots will not be helpful, but they may aggravate these conditions. Further studies are needed to assess the real impact of these devices on sexual dysfunctions, as lack of evidence prevents firmly recommending them as part of treatment protocols.
Circulating Tumor Cell Phenotype Detection and Epithelial‐Mesenchymal Transition Tracking Based on Dual Biomarker Co‐Recognition in an Integrated PDMS Chip
Authors: Xu Hao , Zuo Yingchun , Gao Shuai , Liu Yuping , Liu Tingting , He Shiyu , Wang Mengjiao , Hu Lili , Li Chenglin , Yu Yanyan 
Published: May 2024

AbstractCirculating tumor cells (CTCs) are widely considered as a reliable and promising class of markers in the field of liquid biopsy. As CTCs undergo epithelial‐mesenchymal transition (EMT), phenotype detection of heterogeneous CTCs based on EMT markers is of great significance. In this report, an integrated analytical strategy that can simultaneously capture and differentially detect epithelial‐ and mesenchymal‐expressed CTCs in bloods of non‐small cell lung cancer (NSCLS) patients is proposed. First, a commercial biomimetic polycarbonate (PCTE) microfiltration membrane is employed as the capture interface for heterogenous CTCs. Meanwhile, differential detection of the captured CTCs is realized by preparing two distinct CdTe quantum dots (QDs) with red and green emissions, attached with EpCAM and Vimentin aptamers, respectively. For combined analysis, a polydimethylsiloxane (PDMS) chip with simple structure is designed, which integrates the membrane capture and QDs‐based phenotype detection of CTCs. This chip not only implements the analysis of the number of CTCs down to 2 cells mL−1, but enables EMT process tracking according to the specific signals of the two QDs. Finally, this method is successfully applied to inspect the correlations of numbers or proportions of heterogenous CTCs in 94 NSCLS patients with disease stage and whether there is distant metastasis.
Oxygen‐Evolving Radiotherapy‐Radiodynamic Therapy Synergized with NO Gas Therapy by Cerium‐Based Rare‐Earth Metal‐Porphyrin Framework
Authors: Lin Jinyan , He Yueyang , Li Yang , Chen Jianwu , Liu Xiaolong 
Published: May 2024

AbstractThe efficacy of traditional radiotherapy (RT) has been severely limited by its significant side effects, as well as tumor hypoxia. Here, the nanoscale cerium (Ce)‐based metaloxo clusters (Ce(IV)6)‐porphyrin (meso‐tetra (4‐carboxyphenyl) porphyrin, TCPP) framework loaded with L‐arginine (LA) (denoted as LA@Ce(IV)6‐TCPP) is developed to serve as a multifarious radio enhancer to heighten X‐ray absorption and energy transfer accompanied by O2/NO generation for hypoxia‐improved RT‐radiodynamic therapy (RDT) and gas therapy. Within tumor cells, LA@Ce(IV)6‐TCPP will first react with endogenous H2O2 and inducible NO synthase (iNOS) to produce O2 and NO to respectively increase the oxygen supply and reduce oxygen consumption, thus alleviating tumor hypoxia. Then upon X‐ray irradiation, LA@Ce(IV)6‐TCPP can significantly enhance hydroxyl radical (•OH) generation from Ce(IV)6 metaloxo clusters for RT and synchronously facilitate singlet oxygen (1O2) generation from adjacently‐coordinated TCPP for RDT. Moreover, both the •OH and 1O2 can further react with NO to generate more toxic peroxynitrite anions (ONOO−) to inhibit tumor growth for gas therapy. Benefitting from the alleviation of tumor hypoxia and intensified RT‐RDT synergized with gas therapy, LA@Ce(IV)6‐TCPP elicited superior anticancer outcomes. This work provides an effective RT strategy by using low doses of X‐rays to intensify tumor suppression yet reduce systemic toxicity.
Highly Flexible and Superelastic Graphene Nanofibrous Aerogels for Intelligent Sign Language
Authors: Pang Kai , Ma Jingyu , Song Xian , Liu Xiaoting , Zhang Chengqi , Gao Yue , Li Kaiwen , Liu Yingjun , Peng Yuxin , Xu Zhen , Gao Chao 
Published: May 2024

AbstractHighly flexible and superelastic aerogels at large deformation have become urgent mechanical demands in practical uses, but both properties are usually exclusive. Here a trans‐scale porosity design is proposed in graphene nanofibrous aerogels (GNFAs) to break the trade‐off between high flexibility and superelasticity. The resulting GNFAs can completely recover after 1000 fatigue cycles at 60% folding strain, and notably maintain excellent structural integrity after 10000 cycles at 90% compressive strain, outperforming most of the reported aerogels. The mechanical robustness is demonstrated to be derived from the trans‐scale porous structure, which is composed of hyperbolic micropores and porous nanofibers to enable the large elastic deformation capability. It is further revealed that flexible and superelastic GNFAs exhibit high sensitivity and ultrastability as an electrical sensors to detect tension and flexion deformation. As proof, The GNFA sensor is implemented onto a human finger and achieves the intelligent recognition of sign language with high accuracy by multi‐layer artificial neural network. This study proposes a highly flexible and elastic graphene aerogel for wearable human‐machine interfaces in sensor technology.
N‐methyl Formamide Electrolyte Additive Enabling Highly Reversible Zn Anodes
Authors: Chimtali Peter Joseph , Yang Xiya , Zhou Quan , Wei Shiqiang , Mohamed Zeinab , Akhtar Hassan , Al‐Mahgari Aad , Zhou Yuzhu , Xu Hanchen , Zhang Zijun , Cao Dengfeng , Chen Shuangming , Zhu Kefu , Guo Xin , Shou Hongwei , Wu Xiaojun , Wang Changda , Song Li 
Published: May 2024

AbstractParasitic side reactions and dendrites formation hinder the application of aqueous zinc ion batteries due to inferior cycling life and low reversibility. Against this background, N‐methyl formamide (NMF), a multi‐function electrolyte additive is applied to enhance the electrochemical performance. Studied via advanced synchrotron radiation spectroscopy and DFT calculations, the NMF additive simultaneously modifies the Zn2+ solvation structure and ensures uniform zinc deposition, thus suppressing both parasitic side reactions and dendrite formation. More importantly, an ultralong cycling life of 3115 h in the Zn||Zn symmetric cell at a current density of 0.5 mA cm−2 is achieved with the NMF additive. Practically, the Zn||PANI full cell utilizing NMF electrolyte shows better rate and cycling performance compared to the pristine ZnSO4 aqueous electrolyte. This work provides useful insights for the development of high‐performance aqueous metal batteries.
Freestanding Penta‐Twinned Palladium Nanosheets
Authors: Ahn Hojin , Ahn Hochan , Goo Bon Seung , Kwon Yongmin , Kim Yonghyeon , Wi Dae Han , Hong Jong Wook , Lee Seunghoon , Lee Young Wook , Han Sang Woo 
Published: May 2024

AbstractControl over the morphology of nanomaterials to have a 2D structure and manipulating the surface strain of nanostructures through defect control have proved to be promising for developing efficient catalysts for sustainable chemical and energy conversion. Here a one‐pot aqueous synthesis route of freestanding Pd nanosheets with a penta‐twinned structure (PdPT NSs) is presented. The generation of the penta‐twinned nanosheet structure can be succeeded by directing the anisotropic growth of Pd under the controlled reduction kinetics of Pd precursors. Experimental and computational investigations showed that the surface atoms of the PdPT NSs are effectively under a compressive environment due to the strain imposed by their twin boundary defects. Due to the twin boundary‐induced surface strain as well as the 2D structure of the PdPT NSs, they exhibited highly enhanced electrocatalytic activity for oxygen reduction reaction compared to Pd nanosheets without a twin boundary, 3D Pd nanocrystals, and commercial Pd/C and Pt/C catalysts.