bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thermodynamic analysis and performance study for adsorption refrigeration cycle driven by a fuel cell electric vehicle waste heat
Authors: Yang Pei‐Zhi 
Published: July 2010

AbstractThree kinds of adsorption refrigeration cycles are analyzed in this paper, a two‐bed continuous cycle, an adiabatic mass recovery cycle, and an isothermal mass recovery cycle.Operating parameters (including desorption temperature, adsorption temperature, cycle adsorption rate, COP, and period refrigerating capacity) with the change of the evaporating temperature, condensing temperature, heat capacity ratio, and heat resource temperature are discussed. The analysis indicates that performance differences between the mass recovery cycle and the two‐bed continuous cycle are reduced with an increasing of evaporating temperature and heat source temperature. By increasing the heat capacity ratio, COP values for the three kinds of cycle decrease. When the heat source temperature is between 70 and 90°C, the performance of the isothermal mass recovery cycle is best. Through study, this paper puts forward that the isothermal mass recovery cycle is the best cycle for adsorption refrigeration systems driven by fuel cell electrical vehicle waste heat. © 2010 Wiley Periodicals, Inc. Heat Trans Asian Res, 39(7): 523–538, 2010; Published online 16 July 2010 in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/htj.20315
Multiphoton microscopy system with a compact fiber‐based femtosecond‐pulse laser and handheld probe
Authors: Liu Gangjun , Kieu Khanh , Wise Frank W. , Chen Zhongping 
Published: July 2010

AbstractWe report on the development of a compact multiphoton microscopy (MPM) system that integrates a compact and robust fiber laser with a miniature probe. The all normal dispersion fiber femtosecond laser has a central wavelength of 1.06 μm, pulse width of 125 fs and average power of more than 1 W. A double cladding photonic crystal fiber was used to deliver the excitation beam and to collect the two‐photon signal. The hand‐held probe included galvanometer‐based mirror scanners, relay lenses and a focusing lens. The packaged probe had a diameter of 16 mm. Second harmonic generation (SHG) images and two‐photon excited fluorescence (TPEF) images of biological tissues were demonstrated using the system. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Dark proteins disturb multichromophore coupling in tetrameric fluorescent proteins
Authors: Blum Christian , Meixner Alfred J. , Subramaniam Vinod 
Published: July 2010

AbstractDsRed is representative of the tetrameric reef coral fluorescent proteins that constitute particularly interesting coupled multichromophoric systems. Either a green emitting or a red emitting chromophore can form within each of the monomers of the protein tetramer. Within the tetramers the chromophores are thought to be efficiently fluorescence resonance energy transfer (FRET) coupled. We have used spectrally resolved room temperature single molecule spectroscopy to address the issue of FRET and the role of dark proteins within single protein tetramers of DsRed and its variants DsRed2, DsRed_N42H and AG4. Our results show that for the majority of the tetramers the different chromophores are indeed effectively coupled. However, in a fraction of the tetramers that is characteristic for each DsRed variant analyzed, we observe a lack of effective FRET coupling. For these tetramers we invoke the existence of dark proteins lacking a functional chromophore that interrupt the energy transfer chain within the multichromophoric system. We show that these species lead to donor dequenching that strongly influences the bulk emission spectra. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Inhibition of sclerostin by monoclonal antibody increases bone formation, bone mass, and bone strength in aged male rats
Authors: Li Xiaodong , Warmington Kelly S , Niu Qing-Tian , Asuncion Franklin J , Barrero Mauricio , Grisanti Mario , Dwyer Denise , Stouch Brian , Thway Theingi M , Stolina Marina , Ominsky Michael S , Kostenuik Paul J , Simonet William S , Paszty Chris , Ke Hua Zhu 
Published: July 2010

Abstract
The purpose of this study was to evaluate the effects of sclerostin inhibition by treatment with a sclerostin antibody (Scl-AbII) on bone formation, bone mass, and bone strength in an aged, gonad-intact male rat model. Sixteen-month-old male Sprague-Dawley rats were injected subcutaneously with vehicle or Scl-AbII at 5 or 25 mg/kg twice per week for 5 weeks (9–10/group). In vivo dual-energy X-ray absorptiometry (DXA) analysis showed that there was a marked increase in areal bone mineral density of the lumbar vertebrae (L1 to L5) and long bones (femur and tibia) in both the 5 and 25 mg/kg Scl-AbII-treated groups compared with baseline or vehicle controls at 3 and 5 weeks after treatment. Ex vivo micro–computed tomographic (µCT) analysis demonstrated improved trabecular and cortical architecture at the fifth lumbar vertebral body (L5), femoral diaphysis (FD), and femoral neck (FN) in both Scl-AbII dose groups compared with vehicle controls. The increased cortical and trabecular bone mass was associated with a significantly higher maximal load of L5, FD, and FN in the high-dose group. Bone-formation parameters (ie, mineralizing surface, mineral apposition rate, and bone-formation rate) at the proximal tibial metaphysis and tibial shaft were markedly greater on trabecular, periosteal, and endocortical surfaces in both Scl-AbII dose groups compared with controls. These results indicate that sclerostin inhibition by treatment with a sclerostin antibody increased bone formation, bone mass, and bone strength in aged male rats and, furthermore, suggest that pharmacologic inhibition of sclerostin may represent a promising anabolic therapy for low bone mass in aged men. © 2010 American Society for Bone and Mineral Research.
Fracture healing is accelerated in the absence of the adaptive immune system
Authors: Toben Daniel , Schroeder Ireen , El Khassawna Thaqif , Mehta Manav , Hoffmann Jan-Erik , Frisch Jan-Tilmann , Schell Hanna , Lienau Jasmin , Serra Alessandro , Radbruch Andreas , Duda Georg N 
Published: July 2010

Abstract
Fracture healing is a unique biologic process starting with an initial inflammatory response. As in other regenerative processes, bone and the immune system interact closely during fracture healing. This project was aimed at further elucidating how the host immune system participates in fracture healing. A standard closed femoral fracture was created in wild-type (WT) and recombination activating gene 1 knockout (RAG1−/−) mice lacking the adaptive immune system. Healing was investigated using micro–computed tomography (µCT), biomechanical testing, and histologic and mRNA expression analyses. Biomechanical testing demonstrated a significantly higher torsional moment on days 14 and 21 in the RAG1−/− mice compared to the WT group. µCT evaluation of RAG1−/− specimens showed earlier mineralization and remodeling. Histologically, endochondral ossification and remodeling were accelerated in the RAG1−/− compared with the WT mice. Histomorphometric analysis on day 7 showed a significantly higher fraction of bone and a significantly lower fraction of cartilage in the callus of the RAG1−/− mice than in the WT mice. Endochondral ossification was accelerated in the RAG1−/− mice. Lymphocytes were present during the physiologic repair process, with high numbers in the hematoma on day 3 and during formation of the hard callus on day 14 in the WT mice. Expression of inflammatory cytokines was reduced in the RAG1−/− mice. In contrast, expression of anti-inflammatory interleukin 10 (IL-10) was strongly upregulated in RAG1−/− mice, indicating protective effects. This study revealed an unexpected phenotype of enhanced fracture healing in RAG1−/− mice, suggesting detrimental functions of lymphocytes on fracture healing. The shift from proinflammatory to anti-inflammatory cytokines suggests that immunomodulatory intervention strategies that maximise the regenerative and minimize the destructive effects of inflammation may lead to enhanced fracture repair. © 2011 American Society for Bone and Mineral Research.
A longitudinal study of emotional experience, expressivity, and psychopathology in psychotherapy inpatients and psychologically healthy persons
Authors: Leising Daniel , Grande Tilman , Faber Rainer 
Published: July 2010

AbstractThe authors investigated changes of emotional experience and expressivity in 34 inpatients undergoing psychodynamic therapy and in 29 healthy persons who were assessed at parallel time intervals. Participants completed 2 measures of psychopathology (Symptom Checklist‐90 Revised and Inventory of Interpersonal Problems‐64) and took part in relationship episode interviews. The emotional experiences they reported and their nonverbal emotional expressivity during the interviews were assessed by independent raters. Regardless of when they were assessed, the patients reported a greater number of emotions and a greater variety of emotions. Psychopathology in the patient group decreased in the course of treatment, but there were no systematic changes in the emotional domain. The findings challenge the common notion of psychopathology being associated with impaired awareness and expression of emotions. © 2010 Wiley Periodicals, Inc. J Clin Psychol 66:1–17, 2010.
Chemical cross‐linking with a diazirine photoactivatable cross‐linker investigated by MALDI‐ and ESI‐MS/MS
Authors: Gomes Alexandre F. , Gozzo Fabio C. 
Published: July 2010

AbstractCrystallography and nuclear magnetic resonance are well‐established methods to study protein tertiary structure and interactions. Despite their usefulness, such methods are not applicable to many protein systems. Chemical cross‐linking of proteins coupled with mass spectrometry allows low‐resolution characterization of proteins and protein complexes based on measuring distance constraints from cross‐links. In this work, we have investigated cross‐linking by means of a heterobifunctional cross‐linker containing a traditional N‐hydroxysuccinimide (NHS) ester and a UV photoactivatable diazirine group. Activation of the diazirine group yields a highly reactive carbene species, with potential to increase the number of cross‐links compared with homobifunctional, NHS‐based cross‐linkers. Cross‐linking reactions were performed on model systems such as synthetic peptides and equine myoglobin. After reduction of the disulfide bond, the formation of intra‐ and intermolecular cross‐links was identified and the peptides modified with both NHS and diazirine moieties characterized. Fragmentation of these modified peptides reveals the presence of a marker ion for intramolecular cross‐links, which facilitates identification. Copyright © 2010 John Wiley & Sons, Ltd.
Potential of atmospheric pressure chemical ionization source in GC‐QTOF MS for pesticide residue analysis
Authors: Portolés T. , Sancho J. V. , Hernández F. , Newton A. , Hancock P. 
Published: July 2010

AbstractThe potential applications of a new atmospheric pressure source for GC‐MS analysis have been investigated in this work. A list of around 100 GC‐amenable pesticides, which includes organochlorine, organophosphorus and organonitrogenated compounds, has been used to evaluate their behavior in the new source. Favoring the major formation of the molecular ion in the source has been the main goal due to the wide‐scope screening possibilities that this fact brings in comparison with the traditional, highly fragmented electron ionization spectra. Thus, the addition of water as modifier has been tested as a way to promote the generation of protonated molecules. Pesticides investigated have been classified into six groups according to their ionization/fragmentation behavior. Four of them are characterized by the abundant formation of the protonated molecule in the atmospheric pressure source, mostly being the base peak of the spectrum. These results show that wide‐scope screening could be easily performed with this source by investigating the presence of the protonated molecule ion, MH+. The developed procedure has been applied to pesticide screening in different food samples (nectarine, orange and spinach) and it has allowed the presence of several pesticides to be confirmed such as chlorpyriphos ethyl, deltamethrin and endosulfan sulfate. The availability of a quadrupole time‐of‐flight instrument made it feasible to perform additional MS/MS experiments for both standards and samples to go further in the confirmation of the identity of the detected compounds. Results shown in this paper have been obtained using a prototype source which exhibits promising features that could be applied to other analytical problems apart from those illustrated in this work. Copyright © 2010 John Wiley & Sons, Ltd.
Web 2.0: Read, write, create, connect, and learn—opportunities for online learning
Authors: Parscal Tina J. 
Published: July 2010

AbstractThis article examines the uses of Web 2.0 technologies in online education: blogs, wikis, social networking, social bookmarking, and virtual gaming environments. It also presents research on the pedagogical uses of Web 2.0 in online education and training; the theoretical underpinnings of this pedagogy; implications for colleges, universities, and organizations that adopt Web 2.0 technologies; and future trends and the systemic impact of Web 2.0. According to Thompson (2008, p. 22), “Web 2.0 offers educators new teaching and learning tools. Web 2.0 can change the way teachers interact with students and how students interact among themselves.”
Excellent leaders do better than fixing problems—they foresee them
Authors: Price Daniel R. 
Published: July 2010

AbstractKnow What You Don't Know: How Great Leaders Prevent Problems Before They HappenBy Michael A. RobertoUpper Saddle River, NJ: Wharton School Publishing, 2009. 202 pp. ISBN‐13 978‐0‐13‐156615‐0. $27.99.
Myers‐Briggs and psychological type and change style for hospital executives
Authors: Lawrence Eleanor T. 
Published: July 2010

AbstractThis research explored psychological type and change style for hospital executives and the implications for leading organizational change using the Myers‐Briggs Type Indicator Form Q and the Change Style Indicator. As societal demands increase for hospitals to transform, it becomes vital for executives to understand their own needs, responses, and strengths during organizational change and those of their followers. Forty‐five hospital executives participated in this study. The descriptive statistics for psychological type MBTI were ISTJ (20%), followed by ENTP (17.8%) and ISFJ (13.3%). The most frequently reported CSI style was Originator (40.7%), followed by Conserver (31.2%) and Pragmatist (28.9%). Results indicated that ENTP type was overrepresented at a statistically significant level of .001 in comparison to the CPP Healthcare Sample (2006) and the CAPT Healthcare Administrator Sample (1986). CSI styles were not overrepresented at a statistically significant level. There were statistically significant associations between MBTI type and CSI Originator style, MBTI preferences and the CSI Originator style, specific MBTI preferences, and the CSI Conserver style. MBTI and CSI tools help hospital executives understand and manage the effect of their psychological type and change style when leading organizational change. The study provides baseline information for a more informed and flexible approach to organizational change using psychological type in conjunction with change style.
Kinetics of the gas‐phase reactions of CHXCFX (X = H, F) with OH (253–328 K) and NO3 (298 K) radicals and O3 (236–308 K)
Authors: Chen L. , Uchimaru T. , Kutsuna S. , Tokuhashi K. , Sekiya A. 
Published: July 2010

AbstractRate constants for the reactions of OH and NO3 radicals with CH2CHF (k1 and k4), CH2CF2 (k2 and k5), and CHFCF2 (k3 and k6) were determined by means of a relative rate method. The rate constants for OH radical reactions at 253–328 K were k1 = (1.20 ± 0.37) × 10−12 exp[(410 ± 90)/T], k2 = (1.51 ± 0.37) × 10−12 exp[(190 ± 70)/T], and k3 = (2.53 ± 0.60) × 10−12 exp[(340 ± 70)/T] cm3 molecule−1 s−1. The rate constants for NO3 radical reactions at 298 K were k4 = (1.78 ± 0.12) × 10−16 (CH2CHF), k5 = (1.23 ± 0.02) × 10−16 (CH2CF2), and k6 = (1.86 ± 0.09) × 10−16 (CHFCF2) cm3 molecule−1 s−1. The rate constants for O3 reactions with CH2CHF (k7), CH2CF2 (k8), and CHFCF2 (k9) were determined by means of an absolute rate method: k7 = (1.52 ± 0.22) × 10−15 exp[−(2280 ± 40)/T], k8 = (4.91 ± 2.30) × 10−16 exp[−(3360 ± 130)/T], and k9 = (5.70 ± 4.04) × 10−16 exp[−(2580 ± 200)/T] cm3 molecule−1 s−1 at 236–308 K. The errors reported are ±2 standard deviations and represent precision only. The tropospheric lifetimes of CH2CHF, CH2CF2, and CHFCF2 with respect to reaction with OH radicals, NO3 radicals, and O3 were calculated to be 2.3, 4.4, and 1.6 days, respectively. © 2010 Wiley Periodicals, Inc. Int J Chem Kinet 42: 619–628, 2010
Analysis of laryngeal framework surgery: 10‐year follow‐up to a national survey
Authors: Young VyVy N. , Zullo Thomas G. , Rosen Clark A. 
Published: July 2010

AbstractObjectives:Laryngeal framework surgery, including medialization laryngoplasty (ML) and arytenoid adduction (AA), are common treatments for vocal fold paralysis and glottal incompetence. Little information is known about the incidence of ML/AA surgery nationwide, in particular the success and complication rates.Methods:A 25‐item questionnaire was mailed to 6,644 Board‐certified otolaryngologists.Results:The response rate was 25.7% (n = 1,707). Sixty‐three percent perform ML and/or AA, representing 29,748 procedures. Experience with Silastic medialization implants has decreased over time, while utilization of other materials has increased. The overall complication rate was 15%, including 0.8% implant extrusion and 6% revision rates. The most common revision was placement of a larger implant (37% of all revisions). Airway compromise requiring intervention was observed in 2.2%, and suboptimal voice outcome in 4%. Although not statistically significant, a trend was observed of decreasing complication rate with increasing experience.Conclusions:Laryngeal framework surgeries are being performed with increasing frequency in the United States. The overall complication rate is slightly increased in the present study, but airway compromise and poor vocal outcome are decreased, and the need for revision surgery is unchanged. These findings suggest a continued high level of efficacy of these procedures. Laryngoscope, 2010
Pharmacological protection of hearing loss in the mouse model of endolymphatic hydrops
Authors: Melki Sami J. , Heddon Chris M. , Frankel Jonathan K. , Levitt Alex H. , Momin Suhael R. , Alagramam Kumar N. , Megerian Cliff A. 
Published: July 2010

AbstractObjectives/Hypothesis:Excitotoxic and related inflammatory injury are implicated in the spiral ganglion degeneration seen with Meniere's disease and endolymphatic hydrops (ELH). Excitotoxicity is initiated with glutamate elevation and associated with downstream increases in reactive oxygen species resulting in inflammation‐mediated neuronal degeneration. This study tests the hypothesis that interruption of the initial and/or downstream aspects of excitotoxicity should provide hearing protection in ELH‐associated hearing loss.Study Design:This study tests whether riluzole, a glutamate release inhibitor, and dimethylsulfoxide (DMSO), an anti‐inflammatory and antioxidant solvent with favorable properties at the level of glutamate receptors, can protect against early‐stage hearing loss in a mouse model of ELH.Methods:ThePhexHyp‐Dukmouse spontaneously develops ELH and postnatal hearing loss. Starting at postnatal day 6 (P6), daily injections of riluzole + DMSO or just DMSO were administered. Untreated mutants served as controls. At P21, P25, and P30, hearing function was assessed by recording auditory brainstem responses. A cochlear function index was developed to assess global cochlear function at each time point.Results:Compared to no treatment, DMSO provided significant hearing protection (P< .05). The riluzole + DMSO also showed protection, but it was statistically indistinguishable from DMSO alone; a synergistic increase in protection with riluzole was not observed.Conclusions:This study demonstrates pharmacological hearing protection in an animal model of ELH. The results support the assertion that inflammatory (reactive oxygen species) injury, which is part of the excitotoxic pathway, contributes to the development of ELH‐associated hearing loss. Laryngoscope, 2010
Evaluation of intraoperative parathormone measurement for predicting successful surgery in patients undergoing subtotal/total parathyroidectomy due to secondary hyperparathyroidism
Authors: Kara Melih , Tellioglu Gurkan , Bugan Ugur , Krand Osman , Berber Ibrahim , Seymen Pinar , Eren Pinar Ata , Ozel Leyla , Titiz Izzet 
Published: July 2010

AbstractObjectives/Background:The aim of this study is to investigate the predictive value of intraoperative parathormone measurement addressing successful surgical resection in patients with secondary hyperparathyroidism.Methods:The study included 42 consecutive patients operated on between May 2006 and July 2008. Patients were grouped according to successful surgery (Group 1, n = 36) and persistent postoperative hyperparathyroidism (Group 2, n = 6). Serum phosphorus (P), total calcium (tCa), ionized calcium (iCa), intact parathormone (iPTH), and alkaline phosphatase (ALP) were drawn preoperatively and intraoperatively upon 15 minutes after completion of resection (iPTH15). The rate of decrease of pith detected by iPTH15 compared to preoperative values was calculated (iPTH%).Results:Preoperative P, tCa, iCa, iPTH, and ALP were comparable. Subtotal parathyroidectomy (sPx) (n = 27) and total parathyroidectomy with autotransplantation (tPx) (n = 15) were performed. Mean iPTH15 value, iPTH% rates were 145.9 ± 12.3 pg/mL, % 91.6 ± 0.7, and 522.5 ± 85.4 pg/mL, % 75.1 ± 2.0 (P = ,001) in Groups 1 and 2, respectively. Mean serum tCa and iCa at POD#1 in Group 1 were 7.6 ± 0.1 mg/dL, 0.910 ± 0.4 mmol/L, and Group 2 were 8.3 ± 0.3 mg/dL, 1.050 ± 0.4 mmol/L (P < .05), respectively. ALP levels were similar.Conclusion:iPTH15 value and iPTH% rate accurately predicts the completeness of resection in secondary hyperparathyroidism. The rate of decrease in serum iPTH detected intraoperatively compared to preoperative baseline levels exceeding 90% in sPx, 95% in tPx, accurately predicts the success of surgery. Postoperative normocalcemia without calcium replacement would raise a suspicion about completeness of surgical resection. Laryngoscope, 2010