bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral DHA supplementation and retinopathy of prematurity: the Joinville DHA Clinical Trial
Authors: Cagliari Patrícia Zanotelli , Hoeller Vinícius Ricardo Franzoi , Kanzler Émelli Louise Rüncus , Carraro Melody Cristina Mansani , Corrêa Zaine Glaci Duarte , Blazius Gleici , Marghetti Pietra Giovanna , Lenz Gabriela Bruns , Mastroeni Silmara Salete de Barros Silva , Mastroeni Marco Fabio 
Published: June 2024

AbstractRetinopathy of prematurity (ROP) is a leading cause of blindness in premature infants. The condition is associated with DHA deficiency. This study aimed to investigate the effect of DHA supplementation on the occurrence of ROP in infants receiving oral oil drops. It is part of the Joinville DHA study, a non-parallel-group cohort study conducted from March 2020 to January 2023 at a public maternity hospital in Brazil. Infants born before 33 weeks of gestational age or with a birth weight ≤ 1500 g were recruited. Among 155 infants, 81 did not receive and 74 received DHA supplementation until complete vascularisation of the peripheral retina. There was a higher incidence of infants with ROP in the unsupplemented group (58·6 %) compared with the DHA group (41·4 %), but this difference was NS (P = 0·22). Unadjusted logistic regression analysis showed that patent ductus arteriosus and neonatal corticosteroids were significantly (P < 0·05) associated with ROP in both groups. In the DHA group, surfactant use was also associated with ROP (P = 0·003). After adjusting for important covariates, patent ductus arteriosus and neonatal corticosteroids continued to be significant for infants in the unsupplemented group (OR = 3·99; P = 0·022 and OR = 5·64; P = 0·019, respectively). In the DHA group, only surfactant use continued to be associated with ROP (OR = 4·84; P = 0·015). In summary, DHA supplementation was not associated with ROP. Further studies are necessary to better understand the relationship between DHA supplementation, ROP and associated comorbidities.
The amino acid sensor methionyl-tRNA synthetase is required for methionine-induced milk protein synthesis in a domestic pigeon model
Authors: Lu Panpan , Zhong Chen , Zhao Hongwei , Li Fuyong , Wang Xiaofan , Wang Xiuqi , Yan Huichao , Gao Chunqi 
Published: June 2024

AbstractThis study was conducted to investigate whether methionyl-tRNA synthetase (MetRS) is a mediator of methionine (Met)-induced crop milk protein synthesis via the janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) signalling pathway in breeding pigeons. In Experiment 1, a total of 216 pairs of breeding pigeons were divided into three groups (control, Met-deficient, and Met-rescue groups). In Experiments 2 and 3, forty pairs of breeding pigeons from each experiment were allocated into four groups. The second experiment included a control group and three MetRS inhibitor (REP8839) groups. The third experiment included a Met-deficient group, Met-sufficient group, REP8839 + Met-deficient group and REP8839 + Met-sufficient group. Experiment 1 showed that Met supplementation increased crop development, crop milk protein synthesis, the protein expression of MetRS and JAK2/STAT5 signalling pathway, and improved squab growth. Experiment 2 showed that crop development, crop milk protein synthesis and the protein expression of MetRS and the JAK2/STAT5 signalling pathway were decreased, and squab growth was inhibited by the injection of 1·0 mg/kg body weight REP8839, which was the selected dose for the third experiment. Experiment 3 showed that Met supplementation increased crop development, crop milk protein synthesis and the expression of MetRS and JAK2/STAT5 signalling pathway and rescued squab growth after the injection of REP8839. Moreover, the co-immunoprecipitation results showed that there was an interaction between MetRS and JAK2. Taken together, these findings indicate that MetRS mediates Met-induced crop milk protein synthesis via the JAK2/STAT5 signalling pathway, resulting in improved squab growth in breeding pigeons.
Comparison of protein digestibility of human milk and infant formula using the INFOGEST method under infant digestion conditions
Authors: Komatsu Yosuke , Wada Yasuaki , Shibasaki Takuya , Kitamura Yohei , Ehara Tatsuya , Nakamura Hirohiko , Miyaji Kazuhiro 
Published: June 2024

AbstractMany improvements have been made to bring infant formula (IF) closer to human milk (HM) regarding its nutritional and biological properties. Nevertheless, the protein components of HM and IF are still different, which may affect their digestibility. This study aimed to evaluate and compare the protein digestibility of HM and IF using the infant INFOGEST digestion method. Pooled HM and a commercial IF were subjected to the infant INFOGEST method, which simulates the physiological digestion conditions of infants, with multiple directions, i.e. the curd state, gel images of SDS-PAGE, molecular weight distribution, free amino acid concentrations and in vitro protein digestion rate. HM underwent proteolysis before digestion and tended to have a higher protein digestion rate with finer curds during gastric digestion, than the IF. However, multifaceted analyses showed that the protein digestibility of HM and IF was not significantly different after gastrointestinal digestion. In conclusion, the infant INFOGEST method showed that the digestibility of HM and IF proteins differed to some extent before digestion and after gastric digestion, but not at the end of gastrointestinal digestion. The findings of this study will contribute to the refinement of IF with better protein digestibility in infant stomach.
PHILOSOPHY IN DIO CHRYSOSTOM, ON ANACHÔRÊSIS (ORATION 20)
Authors: Jażdżewska Katarzyna 
Published: June 2024

AbstractThis article uncovers the intellectual traditions behind Dio Chrysostom's Oration 20: On Anachôrêsis. The examination reveals a variety of subtexts and traditions with which Dio engages, and shows that at its core the text inspects three types of lives promoted by three philosophical schools: Epicurean, Stoic and Peripatetic. They are never referred to directly, however, which raises questions concerning Dio's strategy of not acknowledging the sources of the ideas with which he engages. The article also develops our understanding of anachôrêsis and the controversies surrounding it in pagan antiquity.
Cestode diversity in shrews from islands in the Sea of Japan and the Sea of Okhotsk
Authors: Kornienko S.A. , Dokuchaev N.E. 
Published: June 2024

Abstract
A comparative analysis of taxonomic diversity on shrew cestodes among four islands in the Sea of Japan and the Sea of Okhotsk (Sakhalin, Kunashir, Hokkaido, and Moneron) was performed. Cestode species shared among the islands were identified and their host specificity was investigated. On Sakhalin Island, 33 species of the families Hymenolepididae, Dilepididae and Mesocestoididae were recorded in four shrew species (Sorex caecutiens, S. gracillimus, S. minutissimus and S. unguiculatus). In S. caecutiens, S. gracillimus, and S. unguiculatus on Kunashir Island, 22 species of the same families were found and, on Hokkaido Island, 23 species of the families Hymenolepididae and Dilepididae were recorded. On Moneron Island, three species of cestodes were registered in S. tundrensis. The Sakhalin–Hokkaido–Kunashir complex of shrew cestodes includes eastern-Palearctic, trans-Palearctic and endemic species. High endemism (~22%) of shrew tapeworms in the Sakhalin–Kunashir–Hokkaido Islands was noted as compared to continental territories. The different numbers of cestode species in S. unguiculatus (31), S. caecutiens (29), S. gracillimus (19) and S. minutissimus (1) were found. It was concluded that the cestodes species diversity of shrews of Sakhalin–Kunashir–Hokkaido depended primarily on the history of island formation, their modern physical and geographical features, the abundance of definitive and intermediate cestodes hosts and, to a lesser extent, on the size and remoteness of the islands from the mainland and the diversity of host species.
Systematics and life cycles of four avian schistosomatids from Southern Cone of South America
Authors: Oyarzún-Ruiz P. , Thomas R. , Santodomingo A. , Zamorano-Uribe M. , Moroni M. , Moreno L. , Muñoz-Leal S. , Flores V. , Brant S. 
Published: June 2024

Abstract
Relative to the numerous studies focused on mammalian schistosomes, fewer include avian schistosomatids particularly in the southern hemisphere. This is changing and current research emerging from the Neotropics shows a remarkable diversity of endemic taxa. To contribute to this effort, nine ducks (Spatula cyanoptera, S.versicolor, Netta peposaca), 12 swans (Cygnus melancoryphus) and 1,400 Physa spp. snails from Chile and Argentina were collected for adults and larval schistosomatids, respectively. Isolated schistosomatids were preserved for morphological and molecular analyses (28S and COI genes). Four different schistosomatid taxa were retrieved from birds: Trichobilharzia sp. in N. peposaca and S. cyanoptera that formed a clade; S.cyanoptera and S. versicolor hosted Trichobilharzia querquedulae; Cygnus melancoryphus hosted the nasal schistosomatid, Nasusbilharzia melancorhypha; and one visceral, Schistosomatidae gen. sp., which formed a clade with furcocercariae from Argentina and Chile from previous work. Of the physid snails, only one from Argentina had schistosomatid furcocercariae that based on molecular analyses grouped with T. querquedulae. This study represents the first description of adult schistosomatids from Chile as well as the elucidation of the life cycles of N.melancorhypha and T. querquedulae in Chile and Neotropics, respectively. Without well-preserved adults, the putative new genus Schistosomatidae gen. sp. could not be described, but its life cycle involves Chilina spp. and C. melancoryphus. Scanning electron microscopy of T. querquedulae revealed additional, undescribed morphological traits, highlighting its diagnostic importance. Authors stress the need for additional surveys of avian schistosomatids from the Neotropics to better understand their evolutionary history.
First Corinthians 6.1–6: Roman Court or Private Arbitration?
Authors: Ziv Roi 
Published: June 2024

AbstractFirst Corinthians 6.1–6 is consistently read as a Pauline criticism directed against members of the Pauline ekklēsia in Corinth, taking each other to Roman courts. I argue that this understanding of 1 Cor 6.1–6 is implausible in light of practices of Roman law in the provinces and in the colonies. Within a formal court procedure, the Corinthians would not have had the freedom to appoint their own judges, as Paul's language implies. I suggest instead that it is private arbitration which Paul criticises. Papyri dealing with private arbitration and mediation support this reading. Much of Paul's legal terminology in the passage is found in these papyri, making private arbitration a highly plausible suggestion. The suggested reading points to the community's good social ties with the pagan population in the city. It also depicts Paul as working within the framework of Roman law rather than against it. The article exemplifies the benefits of integrating up-to-date studies of Roman law in New Testament Studies.
Deeds of Will on Papyrus and the Use of the Term διαθήκη in the Letters of Paul
Authors: Popa Romeo 
Published: June 2024

AbstractThe numerous testaments on papyrus provide a valuable basis for an investigation of legal language around διαθήκη in the Pauline letters. Of particular importance is the ancient practice of revoking wills, which I consider to be the legal frame of reference for the recipients of the Pauline letters to grasp expressions like καινὴ/παλαιὰ διαθήκη. In the Corinthian correspondence the conformity to the current legal practice is evident, but in Galatians Paul turns the whole procedure upside down, manipulating in the construction of his argument not only the practice of testamentary cancellation, but also the traditional connection of Abraham with circumcision. We are compelled to a text-internal solution of the problem in Gal 3.15–17 by the fact that the papyrological evidence shows clearly that no other type of document than the ordinary revocable διαθήκαι can be taken into consideration. This approach is not compilatory, as it is often the case when dealing with documentary papyri applied to New Testament texts, but heuristic, with the purpose of elaborating new exegetical insights in old controversies.
Fostering societal participation of marginalised people in street-outreach services in the Netherlands
Authors: Rauwerdink-Nijland Evelien , van den Dries Linda , Metz Judith , Verhoeff Arnoud , Wolf Judith 
Published: June 2024

Abstract
Marginalisation is a multilevel phenomenon in society depriving people from essential rights, resources, and opportunities. Street-outreach services in the Netherlands, like social street work (SSW), support these marginalised people in fostering their participation in society as an answer to their marginalised position in society. We followed 927 clients in SSW over an eight-month period. Clients filled in a questionnaire at three timepoints. We examined whether clients’ perceived belongingness, self-esteem, strengths, and informal support (outcome measures) were associated with the working relationship, over time. Results showed the establishment of a working relationship with clients at all three timepoints. An evolving working relationship was associated with an increase in clients’ perceived belongingness, self-esteem, strengths, and informal support over time. This study showed the ability of workers to establish a working relationship with clients in their living environment and underscored the necessity of establishing a working relationship in street-outreach services to foster clients’ participation in society. This study encourages policymakers to reflect on current street-outreach services, to deviate from demanding short-term and measurable results from professionals’ efforts, and to opt for a better fit between performance and financing conditions and daily practices of street-outreach services.
Overexpression of PD-L1 causes germ cell failure and infertility via CRISP1/PD-L1 interaction in mouse epididymis
Authors: Li Ting , Guo Hongmin 
Published: June 2024

SummarySpermatogenesis is a highly complex process through which mature sperms are produced, and it requires three important stages; mitosis, meiosis and sperm formation. The expression of genes regulated by transcription factors at specific stages exerts important regulatory effects on the development process of germ cells. Male mice with overexpressed programmed death ligand 1 (PD-L1) (B7 homolog1) in the testis have infertility and abnormal sperm development, thereby exhibiting severe malformation and sloughing throughout spermatid maturation and collapsed and disorganized seminiferous epithelium structure. Furthermore, PD-L1 overexpression causes overexpression of cysteine-rich secretory protein 1 (CRISP1) in the epididymis and adversely affects or precludes sperm energization, sperm-pellucida binding and sperm-oocyte fusion. These findings suggest that CRISP1 and PD-L1 can interact with each other to induce male infertility and germ-cell dissociation.
A rare case of intra-ovarian oocyte maturation
Authors: Jobson Sara , Hamel Jean-François , Mercier Annie 
Published: June 2024

SummaryThe intra-ovarian presence of ootids, i.e. female gametes that have completed meiosis, is considered exceptional in the animal kingdom. The present study explores the first such case to be reported in a sea cucumber (Echinodermata: Holothuroidea). In the overwhelming majority of animals, including holothuroids, oocytes (i.e. immature female gametes) that are developing in the ovary undergo a primary arrest at the prophase stage of meiosis, which may last from days to decades. In free-spawning taxa, this arrest is normally lifted only during or shortly before transit in the gonoduct, when gamete release (spawning) is imminent. However, oocytes of the holothuroid Chiridota laevis were discovered to have resumed the second meiotic division including the completion of germinal vesicle breakdown and polar-body expulsion inside the ovary, effectively reaching the ootid stage concomitantly with ovulation (i.e. escape from follicle cells) prior to spawning. The potential drivers and significance of this exceptionally rare case of full intra-ovarian oogenic maturation are discussed.
Rome: The Game. Creating an online course as an interactive adventure game
Authors: Moser Claudia , Thomas Christian 
Published: June 2024

AbstractIn this article, we focus on the development of Rome: The Game – a large, lower-division online course crossed-listed in the History of Art and Architecture Department and Writing Program at the University of California, Santa Barbara – that features a choose-your-own-adventure-style interactive narrative. We explore the design principles underpinning the development of this type of gamified course, the mechanics of the course itself, student experiences, and learning outcomes. Citing relevant research in several fields – such as game studies, educational psychology, and communication studies – we argue that creating an online course in the style of an interactive, narrative-driven digital game presents a model for engaging and effective active learning in an online environment – one that goes beyond conventional virtual learning to offer an innovative, active, and deeply immersive model for online teaching.
Association Between Rheumatoid Arthritis and Clonal Hematopoiesis: A Mendelian Randomization Study
Authors: Zhang Jie , Zhou Chun , Guan Shaoxing 
Published: June 2024

AbstractImmunity activation and inflammation are the main characteristics of rheumatoid arthritis and clonal hematopoiesis. However, it remains unclear whether rheumatoid arthritis increase the risk of clonal hematopoiesis. Here, a Mendelian randomization (MR) analysis was conduct to explore the causal effects of rheumatoid arthritis on clonal hematopoiesis. Summary statistics data of rheumatoid arthritis (13,838 cases and 33,742 controls) and clonal hematopoiesis (10,203 cases and 173,918 controls) derived from a genomewide association study were selected to analyze. We selected inverse-variance weighted, MR-Egger, weighted median, simple mode, and weighted mode to evaluate the causal effect of rheumatoid arthritis on clonal hematopoiesis. The two-sample MR analysis suggested a strong causal relationship between rheumatoid arthritis and clonal hematopoiesis by inverse-variance weighted (OR = 1.002311673, 95% CI [1.000110757, 1.004517433], p = .039706) and weighted median (OR = 1.002311673, 95% CI [1.000110757, 1.004517433], p = .039518447) methods. No significant pleiotropy or heterogeneity was found in the sensitivity analysis. These results supported a potentially causal relationship between rheumatoid arthritis and clonal hematopoiesis, and the exposure of rheumatoid arthritis increased the risks of clonal hematopoiesis. Our findings highlight the importance of how chronic inflammation and immune activation induced rheumatoid arthritis enhances the risks of clonal hematopoiesis, and that early intervention with rheumatoid arthritis patients might reduce the clonal hematopoiesis risks in rheumatoid arthritis patients. Moreover, our study provides clues for prediction of risk factors and potential mechanisms of clonal hematopoiesis.
Influence of Microbial Activities on Fluorescent Dissolved Organic Matter in the Dark Canada Basin Waters
Authors: Sylvestre N. , Guéguen C. 
Published: June 2024

AbstractThe fluorescence characteristics of dissolved organic matter (DOM) were measured to determine the distribution and drivers of DOM in the dark Canada Basin waters. We studied the relationship between fluorescent DOM (FDOM) and apparent oxygen utilization (AOU) in the whole water column as well as in the main water masses (Pacific Winter Water, Atlantic halocline (AH), Atlantic water—Fram Strait and Barents Sea branches, Deep Temperature Minimum, and Canada Basin deep water). The relative water mass fractions of different water masses were estimated using a five end‐members mixing model. The distribution of water mass fractions was found to be in good agreement with the distribution based on the traditional temperature‐salinity diagram. The fractions of AH waters were linked with AOU, highlighting the significant role played by mineralization in shaping AH humic‐like levels. The slope of the relationship between in situ FDOM—AOU was greater than those reported in the other oceans worldwide. This suggests that the AH is a hot spot for microbial mineralization of humic‐like DOM. On the other hand, the relationships with the humic‐like intensities differed among the four humic‐like components in the >125 m waters, indicating distinct environmental dynamics and biogeochemical roles for each humic‐like component.
Divergent Impacts of Evapotranspiration by Plant CO2 Physiological Forcing on the Mean and Variability of Water Availability
Authors: Li Ziwei , Sun Fubao , Liu Wenbin , Wang Hong , Wang Tingting , Feng Yao , Tang Senlin 
Published: June 2024

AbstractVegetation responses to rising atmospheric CO2 levels can significantly affect water availability (defined as precipitation minus evapotranspiration (ET)). While this effect has long been recognized and assessed for the mean state, its influence on interannual variability, which is more closely associated with extreme events, has yet to be comprehensively quantified. In this study, our primary focus is to evaluate the impacts of ET by plant physiology (denoted as ETPhy) on the mean and interannual variability of water availability under elevated CO2 using multiple CO2 sensitivity experiments from the coupled model intercomparison project phase 6. We show that the contribution of vegetation physiological effects to the mean water availability varies among regions, while it consistently contributes to variability by about 33%. Considering CO2 physiological effects alone, ETPhy exerts a more significant influence on the mean state than on variability, particularly in humid regions. Consequently, ETPhy contributes less than 5% to the variability of water availability in humid regions under rising CO2, whereas it accounts for about 20% of the mean state. This distinction could be attributed to the different mechanisms governing the mean and variability of ETPhy. Specifically, evaporation from CO2 physiological forcing is the most critical contributor to the variability of ETPhy in most regions while showing minimal impacts on the mean state. Our findings identify the divergent effects of ETPhy on the mean state and interannual variability of water availability under elevated CO2, as important in future climate projections.
Third‐Order Structure Functions of Zonal Winds in the Thermosphere Using CHAMP and GOCE Observations
Authors: Poblet Facundo L. , Liu Huixin , Chau Jorge L. 
Published: June 2024

AbstractWe use multi‐year observations of cross‐track winds (u) from the CHAllenging Minisatellite Payload (CHAMP) and the Gravity Field and Steady State Ocean Circulation Explorer (GOCE) to calculate third‐order structure functions in the thermosphere as a function of horizontal separation (s). They are computed using the mean (〈δu3〉) and the median and implemented over non‐polar satellite paths in both hemispheres. On height averages, 〈δu3〉 is shown to scale with s2 for s ≃ 80–1,000 km, in agreement with equivalent estimates in the lower atmosphere from aircraft observations. Conversely, follows an s3 power law for almost the whole s range, consistent with the two‐dimensional turbulence scaling law for a direct enstrophy cascade. These scaling laws appear independent of winds in distinct atmospheric regions. Furthermore, the functions are predominantly positive, indicating a preferential cyclonic motion for the wind.