bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of renal function variability on long-term prognosis in ischemic stroke patients with atrial fibrillation
Authors: Wang Xiao , Sin Chun-fung , Teo Kay-Cheong , Leung William C. Y. , Wong Yuen-Kwun , Liu Roxanna K. C. , Fok Joshua W. , Ip Bonaventure Y. , Kwan Hon Hang , Lee Tsz Ching , Sheng Bun , Yip Edwin Kin-Keung , Yap Desmond Y. H. , Luo Hao , Lau Kui-Kai 
Published: April 2024

BackgroundAlthough renal dysfunction is associated with adverse clinical outcomes in patients with atrial fibrillation (AF) following stroke, the impact of renal function variability is unclear.AimThis study aimed to assess the association between renal function variability and various adverse clinical outcomes in patients with transient ischemic attack (TIA)/ischemic stroke and atrial fibrillation (AF).MethodsWe conducted a population-based study and retrospectively identified patients hospitalized with a diagnosis of TIA/ischemic stroke and AF during 2016–2020 using the Clinical Data Analysis and Reporting System of Hong Kong. Serial serum creatinine tested upon the onset of TIA/ischemic stroke and during their subsequent follow-up was collected. Renal function variability was calculated using the coefficient of variation of the estimated glomerular filtration rate (eGFR). Clinical endpoints that occurred during the study period were captured and included ischemic stroke/systemic embolism, intracerebral hemorrhage (ICH), total bleeding, major adverse cardiovascular events (MACE), cardiovascular, non-cardiovascular, and all-cause mortality. Competing risk regression and Cox proportional hazard regression models were used to assess the associations of renal function variability with the outcomes of interest.ResultsA total of 3,809 patients (mean age 80 ± 10 years, 43% men) who satisfied the inclusion and exclusion criteria were followed up for a mean of 2.5 ± 1.5 years (9,523 patient-years). The mean eGFR was 66 ± 22 mL/min/1.73 m2 at baseline, and the median number of renal function tests per patient during the follow-up period was 20 (interquartile range 11–35). After accounting for potential confounders, a greater eGFR variability was associated with increased risks of recurrent ischemic stroke/systemic embolism [fully adjusted subdistribution hazard ratio 1.11, 95% confidence interval (CI) 1.03–1.20], ICH (1.17, 1.01–1.36), total bleeding (1.13, 1.06–1.21), MACE (1.22, 1.15–1.30), cardiovascular (1.49, 1.32–1.69), non-cardiovascular (1.43, 1.35–1.52), and all-cause mortality (fully adjusted hazard ratio 1.44, 1.39–1.50).ConclusionVisit-to-visit renal function variability is independently associated with adverse clinical outcomes in TIA/ischemic stroke patients with AF. Further large-scale studies are needed to validate our results.
A study on the association between prefrontal functional connectivity and non-suicidal self-injury in adolescents with depression
Authors: Guo Yan , Lu Ruoxi , Ou Yiwen , Huang Yuxin , Li Jianyu , Cui Ying , Li Danian , Zheng Yanting , Liang Xinyu , Qiu Shijun , Liu Yujie 
Published: April 2024

ObjectiveAmong adolescents with depression, the occurrence of non-suicidal self-injury (NSSI) behavior is prevalent, constituting a high-risk factor for suicide. However, there has been limited research on the neuroimaging mechanisms underlying adolescent depression and NSSI behavior, and the potential association between the two remains unclear. Therefore, this study aims to investigate the alterations in functional connectivity (FC) of the regions in the prefrontal cortex with the whole brain, and elucidates the relationship between these alterations and NSSI behavior in adolescents with depression.MethodsA total of 68 participants were included in this study, including 35 adolescents with depression and 33 healthy controls. All participants underwent assessments using the 17-item Hamilton Depression Rating Scale (17-HAMD) and the Ottawa Self-Harm Inventory. In addition, functional magnetic resonance imaging (fMRI) data of the participants’ brains were collected. Subsequently, the FCs of the regions in the prefrontal cortex with the whole brain was calculated. The FCs showing significant differences were then subjected to correlation analyses with 17-HAMD scores and NSSI behavior scores.ResultCompared to the healthy control group, the adolescent depression group exhibited decreased FCs in several regions, including the right frontal eye field, left dorsolateral prefrontal cortex, right orbitofrontal cortex, left insula and right anterior cingulate coetex. The 17-HAMD score was positively correlated with the frequency of NSSI behavior within 1 year (rs = 0.461, p = 0.005). The FC between the right anterior cingulate cortex and the right precuneus showed a negative correlation with the 17-HAMD scores (rs = −0.401, p = 0.023). Additionally, the FC between the right orbitofrontal cortex and the right insula, demonstrated a negative correlation with the frequency of NSSI behavior within 1 year (rs = −0.438, p = 0.012, respectively).ConclusionAdolescents with depression showed decreased FCs of the prefrontal cortex with multiple brain regions, and some of these FCs were associated with the NSSI frequency within 1 year. This study provided neuroimaging evidence for the neurophysiological mechanisms underlying adolescent depression and its comorbidity with NSSI behavior.
Ophiocordyceps sinensis preparations combined with the renin–angiotensin system inhibitor for diabetic kidney disease treatment: an umbrella review of systematic reviews and network meta-analysis
Authors: Xue Xue , Jin Xin-Yan , Ye Xing-Lan , Li Ke-Ying , Li Jia-Xuan , Liu Xue-Han , Bai Juan , Liu Qiang , Zhang Bing-Rui , Zou Xin-Rong , Yuan Jun , Lu Chun-Li , Zhao Fang-Fang , Liu Jian-Ping , Wang Xiao-Qin 
Published: April 2024

Aims:This study aimed to synthesize the evidence of the comparative effectiveness and safety of Ophiocordyceps sinensis (OS) preparations combined with renin–angiotensin system inhibitors (RASi) for diabetic kidney disease (DKD).Methods:Eight databases were searched from their inception to May 2023. Systematic reviews (SRs) of OS preparations combined with RASi for DKD were identified. Randomized controlled trials (RCTs) from the included SRs and additional searching were performed for data pooling. Cochrane risk-of-bias 2 (RoB 2) tool and AMSTAR 2 were used to evaluate the methodological quality of RCTs and SRs, respectively. A Bayesian network meta-analysis was performed to compare the add-on effect and safety of OS preparations for DKD. The certainty of evidence was graded using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach.Results:Fourteen SRs were included, whose methodological quality was assessed as high (1/14) or critically low (13/14). After combining additional searching, 157 RCTs were included, involving 13,143 participants. The quality of the RCTs showed some concerns (155/157) or high risk (2/157). Jinshuibao capsules and tablets, Bailing capsules and tablets, and Zhiling capsules were evaluated. Compared to RASi, adding either of the OS capsular preparations resulted in a decreased 24-h urinary total protein levels. OS preparations ranked differently in each outcome. Jinshuibao capsules plus RASi were beneficial in reducing urinary protein, serum creatinine, serum urea nitrogen, and blood glucose levels, with moderate-certainty evidence. No serious adverse events were observed after adding OS to RASi.Conclusion:Combining OS capsular preparations with RASi appeared to be associated with decreased urinary total protein levels in DKD patients. Further high-quality studies are needed to confirm.Systematic Review Registration:INPASY202350066.
A prospective study of sleep status, anxiety, and depression levels of college students at a university in Shandong Province, China
Authors: Zhang Chengshuai , Zhao Ling , Dong Tingting , Zhao Ji , Gao Cui , Zhao Feng 
Published: April 2024

ObjectiveTo investigate the changes in sleep conditions, anxiety, and depression levels among college students before and after entering the university.MethodsUtilizing a random sampling method, 692 new students from a college in Shandong province were selected in September 2019, and relevant indices were statistically analyzed in September 2021 following a comprehensive follow-up. Sleep status, anxiety, and depression levels were assessed using the Pittsburgh Sleep Quality Index (PSQI), Patient Health Questionnaire-9 (PHQ-9), and Generalized Anxiety Disorder-7 (GAD-7), respectively.ResultsGender, passive smoking, exercise, intake of fruits, and intake of seafood were identified as significant influencing factors on college students’ sleep status, anxiety, and depression levels (p &lt; 0.05). A substantial difference was observed in the sleep quality of college students between the early enrollment stage and the follow-up stage (p &lt; 0.05). Moreover, a significant positive correlation was found between PSQI scores and the levels of anxiety and depression (p &lt; 0.05), cumulatively explaining approximately 10% of the variance in anxiety and depression levels.ConclusionThe sleep quality of college students exhibited significant improvement after enrollment compared to the early enrollment period. Engaging in appropriate exercise and consuming fruits and seafood demonstrated a positive impact on sleep conditions, anxiety, and depression levels. These findings underscore the importance of fostering healthy lifestyle habits for promoting overall well-being among college students.
Pelatihan Google Education Guna Optimalisasi Penerapan Teknologi Digital Dalam Proses Pembelajaran Guru SD di Kota Madiun
Authors: Pamungkas Ridho , Mumtahana Hani Atun , Rudyanto Hendra Erik , Pradana Lingga Nico 
Published: April 2024

Kegiatan abdimas ini merupakan hilirisasi dari penelitian tim sebelumnya yang mengambil tema analisa dan optimalisasi teknologi digital pada proses pembelajaran sekolah dasar di Kota Madiun. Dari hasil penelitian yang telah dilakukan, kendala yang dialami pada proses pembelajaran, terutama pembelajaran daring diantaranya ialah menguasaan IT atau teknologi digital guru yaitu mendapatkan nilai 12% dimana kendala tersebut merupakan kendala yang meniliki point yang tinggi. Tujuan dari kegiatan abdimas ini adalah meningkatkan softskill atau kemampuan guru dalam penggunaan teknologi digital dalam proses pembelajaran dengan pelatihan penggunaan Google Education dan Pen Tablet. Metode dalam pelaksanaan Kegiatan pengabdian kepada masyarakat ini terdapat empat tahapan diantaranya Survey, Optimalisasi, Materi, dan Evaluasi. Kegiatan abdimas dalam bentuk pendampingan atau pelatihan yang telah dilakukan cukup berhasil, hal tersebuat dapat dilihat dari indikator prosentase peserta yang dapat mengimplementasikan teknologi digital berupa Pen Tablet dan Google Education dengan nilai 72%. Namun setelah dilakukan kegiatan pengabdian ini hendaknya dilakukan kegiatan tindak lanjut agar kemampuan literasi digital guru terus meningkat dan Guru harus mengaplikasikan hasil pelatihan ke dalam pembelajaran agar hasil belajar siswa dapat meningkat.
Compartilhamento do Conhecimento: relação entre gestão do conhecimento e gestão escolar
Authors: Coqueiro Gislaine Souza , Sartori Viviane , Brambilla Marco Aurélio 
Published: April 2024

Este estudo teve como objetivo realizar uma análise dos fatores motivadores do compartilhamento do conhecimento e as competências exigidas ao diretor escolar. Foram analisados os fatores influenciadores e inibidores do compartilhamento do conhecimento na gestão escolar que interferem nas competências profissionais das escolas públicas do Núcleo Regional de Educação de Maringá-Paraná. A metodologia utilizada é de natureza aplicada, com objetivos descritivos e exploratórios; os procedimentos contam com pesquisa bibliográfica e documental e abordagem quantitativa, visando compreender a relação entre o compartilhamento do conhecimento e a gestão escolar.
Palavras-chave: Compartilhamento do conhecimento. Gestão do conhecimento. Gestão escolar.
Uji Stabilitas Fisik Formula Essence pada Sediaan Sheet Mask Ekstrak Kulit Buah Jeruk Purut (Citrus hystrix DC.)
Authors: Prisci Permanasari  , Hernanda Ayu Maulida P  
Published: April 2024

Kaffir lime peel (Citrus hystrix DC.) has been used in several cosmetic formulations because it has ingredients that are beneficial for skin health, such as antioxidants, anti-inflammatories, skin hydration, and brightening. Sheet masks are one of the most popular and widely used skin care products. This study aims to determine the optimal formula for kaffir lime peel extract essence in sheet masks product that meet the physical quality requirements. This research is a laboratory experiment using kaffir lime peel extract which is formulated in three different concentrations, 3%, 5%, and 7%. The formula was tested for stability using the cycling test method with observed parameters including organoleptic, homogeneity, pH and viscosity. Research shows that kaffir lime peel extract which is formulated in sheet mask preparations produces good homogeneity, does not change color, and pH before and after testing. The viscosity was not statistically difference in preparations before and after the cycling test, indicating that the two formulas are stable.

ABSTRAK
Kulit jeruk purut (Citrus hystrix DC.) telah digunakan dalam beberapa formula sediaan kosmetik karena memiliki kandungan yang bermanfaat bagi kesehatan kulit, seperti antioksidan, anti-inflamasi, hidratasi, dan pencerahan kulit. Sheet mask adalah salah satu produk perawatan kulit yang sedang populer dan banyak digunakan. Penelitian ini bertujuan untuk menentukan formula optimal essence pada sediaan sheet mask ekstrak kulit jeruk purut yang memenuhi syarat mutu fisik. Penelitian ini bersifat eksperimental laboratorium dengan menggunakan ekstrak kulit jeruk purut yang diformulasikan dalam tiga konsentrasi yang berbeda yaitu 3%, 5%, dan 7%. Formula tersebut kemudian dilakukan pengujian stabilitas menggunakan metode cycling test dengan parameter pengamatan meliputi organoleptis, homogenitas, pH dan viskositas. Penelitian menunjukan bahwa ekstrak kulit jeruk purut yang diformulasikan dalam sediaan sheet mask menghasilkan sifat homogenitas yang baik, tidak terjadi perubahan warna, dan pH sebelum dan sesudah pengujian. Perbedaan tidak bermakna secara statistik pada pengujian viskositas sediaan sebelum dan sesudah cycling test, menunjukkan bahwa kedua formula tersebut dapat dinyatakan stabil.
Potensi Interaksi Penggunaan Obat Antihipertensi di Klinik X Boyolali Tahun 2023
Authors: Risma Sakti Pambudi  , Helviana Rista Rini  
Published: April 2024

Interactions are events that can occur when two drugs are used together. Giving more than one antihypertensive drug can cause drug interactions which can affect the body's response to the treatment given and can have a therapeutic effect on the patient. The aim of this study was to look at the potential for antihypertensive drug interactions at Clinic X Boyolali. The research used a retrospective descriptive method using medical record data. The population in this study was all medical record data from hypertensive patients at Clinic The method used was purposive sampling by looking at the inclusion criteria, namely patients who used a combination of antihypertensive drugs. In this study, the sample size was 110 patients. The data obtained was then analyzed using drugs.com. The results of the study showed that the highest use of antihypertensive drugs, namely amlodipine and cadesartan, was 72.73% and the potential for drug interactions was 24.55% with a minor interaction level of 57.69%, moderate 38.46% and major 7.69%. The conclusion from this study is that there is potential for drug interactions when using antihypertensive drugs with the majority of interactions being minor.

ABSTRAK
Interaksi merupakan kejadian yang dapat terjadi bila dua obat digunakan bersama. Pemberian obat antihipertensi lebih dari satu dapat menimbulkan interaksi obat yang dapat mempengaruhi respon tubuh terhadap pengobatan yang diberikan dan dapat memberikan efek terapi pasien. Tujuan penelitian ini adalah untuk melihat potensi interaksi obat antihipertensi di Klinik X Boyolali. Penelitian menggunakan metode deskriptif retrospektif dengan menggunakan data rekam medis. Populasi pada penelitian ini adalah seluruh data rekam medik pasien hipertensi di Klinik X Boyolali Tahun 2023 dan sampel dalam penelitian yang sesuai dengan kriteria inklusi yaitu menggunakan kombinasi obat antihipertensi. Metode yang digunakan yaitu purposive sampling dengan melihat kriteria inklusi yaitu pasien yang menggunakan kombinasi obat antihipertensi. Pada penelitian ini didapatkan jumlah sampel 110 pasien Data yang didapat kemudian di analisa menggunakan drugs.com. Hasil penelitian menunjukkan bahwa penggunaan obat antihipertensi tertinggi yaitu amlodipine dan cadesartan 72,73% dan potensi terjadinya interaksi obat yaitu 24,55% dengan tingkat inetraksi minor sebesar 57,69%, moderate 38,46% dan mayor 7,69%. Kesimpulan dari penelitian ini adalah terdapat potensi interaksi obat pada penggunaan obat antihipertensi dengan mayoritas interaksi minor.
NETIZEN BEHAVIOR TOWARDS NON-CONFORMITY AND INCOMPREHENSION IN THE IMPLEMENTATION OF PANCASILA VALUES
Authors: Asy'ari Lathifa Puteri 
Published: April 2024

Pancasila is the foundation and ideology of Indonesia since August 18, 1945. Since then, Indonesian society has followed that all state administration is based on Pancasila. Pancasila contains moral and ethical values that underlie the character of the nation. Although Pancasila guides behavior in Indonesia, including in social media, unfortunately Indonesian people do not fully understand the ethics of social media based on the values of Pancasila. Social media in Indonesia often displays messages without control and ignores ethics. This article aims to investigate how incongruence and incomprehension of Pancasila through cybercrime in social media, as well as its impact on public perception. The research method used qualitative methods, namely descriptive analytical and content analysis. The results showed the lack of awareness of Indonesian society towards social media ethics based on Pancasila values. This reveals that most perpetrators of cybercrime on social media will be trapped by Law Number 11 of 2008 concerning Electronic Information and Transactions (UU ITE), both intentionally and unintentionally.
PENGARUH DUKUNGAN SOSIAL TERHADAP PENYESUAIAN DIRI SANTRI KELAS 7 DI SMP ISLAM EXCELLENT AS SYAFI’AH NGANJUK
Authors: Zahro Umma Ainun 
Published: April 2024

Students who have just entered the Islamic boarding school must be able to adapt themselves. They must participate in all activities that exist at the Islamic boarding school, both formal and non-formal. Besides that, students must adapt well, so social support is needed from people around the students, but the social support given to students is not always optimal, this causes students to have difficulty adjusting themselves. The purpose of this study was to determine the effect of social support on the adjustment of new students in grade 7 at the SMP Islam Excellent As Syafi’ah Nganjuk. This study uses a quantitative with a correlational type that is measured using two scales, namely social support and self-adjustment. The subjects in this study were new students in grade 7 Islamic Middle School Excellent As Syafi'ah Nganjuk. totaling 158 students.
The results in this study indicate that there is an influence of social support on self-adjustment. Social support has a significant effect on adjustment with a sig value of <0.05 (0.000 <0.05) and social support affects adjustment with a percentage value of 32.1%.
USO DE CASCAS DE LARANJA PARA EXTRAÇÃO DE ÓLEO ESSENCIAL E AVALIAÇÃO DE SUAS ATIVIDADES BIOLÓGICAS
Authors: DE SOUZA TERCIO DA , Rodrigues Cindra de Lima Souza Jaqueline , Rodrigues de Souza Gustavo , Do Nascimento Moulin Ester 
Published: April 2024

A expansão da produção de laranja e instalação de agroindústrias mitigam a necessidade de aproveitamento dos resíduos gerados. Este estudo investigou o uso de cascas residuais de laranja para extração de óleo essencial e avaliação de sua potencial atividade biológica. O óleo essencial (OECL) foi obtido da cultivar Valência (Citrus sinensis L.), adquirida no município de Jerônimo Monteiro, Brasil. As cascas frescas foram quantificadas quanto ao teor de umidade e de óleo essencial. O OECL foi caracterizado quanto aos seus atributos físicos (densidade e índice refração), químicos (composição qualitativa/quantitativa) e biológicos (atividade antioxidante, fitotoxicidade e citotoxicidade). As cascas apresentaram 61,5% de umidade e 0,9 % de óleo essencial, este apresentou densidade = 0,8572 g cm-3 e índice de refração = 1,4712 tendo em sua composição: Limoneno (96,37%), Linalol (2,26%) e β-Pineno (1,37%). Dentre as atividades biológicas avaliadas destaca-se o forte carácter antioxidante, concentração efetiva de 89 mg mL-1 para sequestro de 50% do radical livre 2,2-difenil-1-picrilhidrazil. No teste de fitotoxicidade in vitro, com Lactuca sativa, verificou-se que 30 mg mL-1 do OECL não alterou significativamente o processo germinativo, nem o crescimento radicular, mas reduziu em 90% a emissão de folíolos. Já no ensaio de citoxicidade in vitro, 30 mg mL-1 do OECL não afetou a viabilidade do crescimento celular da Saccharomyces cerevisiae, mas reduziu sua atividade enzimática em 30%. A exploração do OECL apresenta-se promissora quanto ao rendimento de obtenção e atividades biológicas, sendo necessários estudos mais aprofundados de seletividade e mecanismos de ação.
PAPEL DA GENÉTICA NA PREDISPOSIÇÃO PARA DOENÇAS CARDÍACAS
Authors: Silva Eliana Marques Gomes da , Silva Erika Fernanda Fernandes da , Costa Isabela Beatriz Oliveira da , Carmo Alaíne Sttefany Martins do , Assunção Leila Jane Brito , Pereira Vitória da Costa , Alfaia Amanda Osman , Gomes Daniela Cavalgante , Sousa Ohana Maria Coelho de , Baptista Liège de Moura Santos Pereira Ferraz , Leal Anne Kaline Marques Portela , Dias Aguinaldo Pereira 
Published: April 2024

A predisposição genética para doenças cardíacas é uma área de crescente interesse na medicina, pois evidências científicas sugerem que certas variantes genéticas podem aumentar significativamente o risco de desenvolvimento de condições como aterosclerose, hipertensão arterial e doença cardíaca coronária. Objetivos: Fornecer uma visão concisa sobre como a genética influencia a predisposição individual para doenças cardíacas. Materiais e Métodos: Para a obtenção de dados, foram empregados os recursos dos seguintes repositórios: Base de Dados em Enfermagem (BDENF), Scientific Electronic Library Online (SCIELO), PubMed e Literatura Latino-Americana do Caribe em Ciências da Saúde (LILACS). Uma variedade de fontes, incluindo artigos científicos, monografias e periódicos, foi examinada para extrair informações pertinentes sobre o assunto. Resultados e Discussões: Estudos genéticos revelam que certas variantes genéticas estão ligadas ao aumento do risco de doenças cardíacas, como aterosclerose e hipertensão. No entanto, é importante notar que a predisposição genética não é o único fator determinante; influências ambientais e comportamentais também desempenham um papel crucial. Uma abordagem integrada é essencial para entender e abordar adequadamente a predisposição genética às doenças cardíacas. Conclusão: Em conclusão, a genética desempenha um papel importante na predisposição para doenças cardíacas, influenciando o risco individual de desenvolver condições cardiovasculares. No entanto, a interação entre fatores genéticos, ambientais e comportamentais é fundamental para compreender completamente essa predisposição e para desenvolver abordagens eficazes de prevenção e tratamento. Uma compreensão mais aprofundada desses aspectos pode levar a intervenções mais personalizadas e direcionadas, melhorando assim a saúde cardiovascular da população.