bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nuevo Caso deLagochilascaris major(Leiper1910) En la República Argentina, parasitando al gato (Felis catus domesticus)
Authors: Romero J. R. , Led J. E. 
Published: August 2010

ResumenSe cita un nuevo caso de parasitismo porLagochilascaris majoren una gata. Los parásitos fueron extraidos de un absceso de la región del músculo masetero. Se realizaron observaciones biométricas. Se comprueba la efectividad del mebendazole, en el tratamiento del caso clínico, intentándose sin resultado la infestación experimental de un gato y de una comadreja(Didelphys azarae).ZusammenfassungEin neuer Fall einer Infestation durchLagochilascaris major(Leiper1910) — Bei einer Katze(Felis Catus dométicus)in ArgentinienEs wird ein neuer Fall von Parasitismus durchLagochilascaris major(Leiper1910), bei einer Katze, in Argentinien beschrieben. Die Parasiten wurden einem Abszeß der masseterischen Gegend entnommen. Biometrische Beobachtungen wurde durchgeführt.Die Wirksamkeit des Mebendazole in diesem klinischen Fall konnte festgestellt werden. Experimentelle Infizierungen einer anderen Katze beziehungsweise eines Marders(Didelphys azarae)gelangen nicht.SummaryA new case ofLagochilascaris major(Leiper1910) — In Argentine Republic in Cat(Felis catus domesticus)A new case of parasitism byLagochilascaris majorin a female cat is reported. The parasites were removed from a subcutaneous abscess in the masseter muscle region and biometric determinations were performed.The effectiveness of mebendazole in the treatment of the clinic case is demonstrated. Attempts at experimental infection of another cat and a weasel(Didelphys azarae)with these nematoda were unsuccessful.RésuméNeuf cas deLagochilascaris major(Leiper1910) — Dans la République Argentine, en Parasitant au Chat(Felis catus domesticus)On cite un neuf cas de parasitisme pourLagochilascaris majordans une chatte. Les parasites ont été extrait d'un abcés de la région du masséter, et fait observations biométriques.On prouve L'efficacité du mebendazole dans le traitement du cas clinique. On prétendant infester experimentalment un chat et una belette(Didelphys azarae)sans résultat.
Beeinflussung der phytomitogen‐induzierten Lymphozytentransformation durch Trichothecene
Authors: Bauer J. , Pawlas Sigrid 
Published: August 2010

ZusammenfassungZehn Trichothecene wurden in vitro geprüft, in welchen Konzentrationen sie noch die Phythämagglutinin‐induzierte Transformation von Schweinelymphozyten hemmen können. Bezüglich der Wirksamkeit ergab sich folgende Reihung: T‐2 Toxin > Diaceto‐xyscirpenol > HT‐2 Toxin > Neosolaniol = Fusarenon × > T‐2 Triol = T‐2 Tetraol = Nivalenol = Deoxynivalenol > Verrucarol.Die Ergebnisse zeigen, daß im Organismus entstehende T‐2 Toxin‐Metaboliten (HT‐2 Toxin, T‐2 Triol, T‐2 Tetraol, Neosolaniol) immer noch eine immunsuppressive Aktivität besitzen, wenn auch in geringerem Ausmafß.SummaryInfluence of trichothecenes on phytomitogen induced lymphocyte transformationTen trichothecenes were examined in vitro in order to test the concentrations in which they are still able to inhibit the phytomitogen induced transformation of peripheral blood lymphocytes of swine. The efficacy of the compounds tested was as follows: T‐2 Toxin > Diacetoxyscirpenol > HT‐2 Toxin > Neosolaniol = Fusarenon × > T‐2 Triol = T‐2 Tetraol = Nivalenol = Deoxynivalenol > Verrucarol.The results show that T‐2 Toxin metabolites produced in the organism still possess immunosuppressive activities although to a lesser degree.RésuméInfluence de la transformation des lymphocytes induite par des phytomitogènes avec des trichothécènesDix trichothécènes ont été examinés in vitro à des concentrations qui pouvaient encore inhiber la transformation induite par phytohémagglutinine des lymphocytes du porc. La classification per efficacité fut la suivante: T‐2 toxine > diacétoxyscirpenol > HT‐2 toxine > réosolaniolfusarenon × > T‐2 triol = T‐2 tetraol = nivalenol = déoxynivalenol > verrucarol.Les résultats montrent que les métabolites de toxine T‐2 dans l'organisme (HT‐2 toxine, T‐2 triol, T‐2 tetraol, néosolanol) possèdent toujours encore une activité immunosuppressive, même à faible quantité.ResumenLa influenciación de la transformación de linfocitos, inducida por fitomitógenos, por tricotecenosSe analizaron «in vitro» diez tricotecenos con la intención de averiguar hasta qué concentraciones pueden inhibir aún la transformación de linfocitos porcinos, inducida por las fitohemoaglutininas. Con respecto a la efectividad se constató la ringla siguiente: toxina T‐2 > diacetoxiescirpenol > toxina HT‐2 > neosolaniol = fusarenona × > triol T‐2 = tetraol T‐2 = nivalenol = deoxinivalenol > verrucarol.Muestran los resultados que los metabolitos de la toxina T‐2 que se forman en el organismo (toxina HT‐2, triol T‐2, tetraol T‐2, neosolaniol) poseen aún una actividad inmunosupresiva, aunque también en grado menor.
Funde von Echinococcus multilocularis bei streunenden Hauskatzen in Süddeutschland
Authors: Meyer H. , Svilenov D. 
Published: August 2010

ZusammenfassungEs wurden 11 streunende Katzen auf Befall rnit Echinococcus multilocularis unter‐sucht. Bei 5 Katzen wurden Stadien dieses Parasiten mit reifen Endgliedern gefunden.SummaryFinding of Echinococcus multilocularis in stray domestic cats in South GermanyEleven stray cats were examined for the presence of E. multilocularis and five of them showed parasites (25—500 per cat) with ripe segments.
Salvage chemotherapy with methotrexate, etoposide and actinomycin D in men with metastatic nonseminomatous germ cell tumors with a choriocarcinoma component: A preliminary report
Authors: Terakawa Tomoaki , Miyake Hideaki , Muramaki Mototsugu , Takenaka Atsushi , Fujisawa Masato 
Published: August 2010

AbstractThe objective of the present study was to assess the use of salvage chemotherapy using methotrexate, etoposide and actinomycin D (MEA) in men with nonseminomatous germ cell tumor (NSGCT) with a choriocarcinoma component. Nine patients were included. They had initially received bleomycin, etoposide and cisplatin, and high‐dose ifosfamide, carboplatin and etoposide as induction chemotherapies. However, they failed to achieve the normalization of β‐human chorionic gonadotropin (β‐HCG). Therefore, MEA therapy (methotrexate: 450 mg/body on day 1, actinomycin D: 0.5 mg/body on days 1–5, etoposide: 100 mg/body on days 1–5) was subsequently administered. After MEA therapy (median: 3 cycles), serum β‐HCG was normalized in five of the nine patients. Of these five, three achieved long‐term disease‐free survival and one died of disease unrelated to NSGCT, whereas the remaining patient developed disease recurrence and died of disease progression. All four patients who failed to achieve the normalization of β‐HCG died of disease progression. Although several severe toxicities greater than grade 3, which were mainly associated with bone marrow suppression, occurred in all patients, there was no treatment‐related death. Considering the current outcomes, MEA regimen could be an attractive option as a salvage chemotherapy for metastatic NSGCT patients with a choriocarcinoma component showing resistance to intensive conventional chemotherapies.
Roles of light and serotonin in the regulation of gastrin‐releasing peptide and arginine vasopressin output in the hamster SCN circadian clock
Authors: Francl Jessica M. , Kaur Gagandeep , Glass J. David 
Published: August 2010

AbstractDaily timing of the mammalian circadian clock of the suprachiasmatic nucleus (SCN) is regulated by photic input from the retina via the retinohypothalamic tract. This signaling is mediated by glutamate, which activates SCN retinorecipient units communicating to pacemaker cells in part through the release of gastrin‐releasing peptide (GRP). Efferent signaling from the SCN involves another SCN‐containing peptide, arginine vasopressin (AVP). Little is known regarding the mechanisms regulating these peptides, as literature on in vivo peptide release in the SCN is sparse. Here, microdialysis–radioimmunoassay procedures were used to characterize mechanisms controlling GRP and AVP release in the hamster SCN. In animals housed under a 14/10‐h light–dark cycle both peptides exhibited daily fluctuations of release, with levels increasing during the morning to peak around midday. Under constant darkness, this pattern persisted for AVP, but rhythmicity was altered for GRP, characterized by a broad plateau throughout the subjective night and early subjective day. Neuronal release of the peptides was confirmed by their suppression with reverse‐microdialysis perfusion of calcium blockers and stimulation with depolarizing agents. Reverse‐microdialysis perfusion with the 5‐HT1A,7 agonist 8‐OH‐DPAT ((±)‐8‐hydroxydipropylaminotetralin hydrobromide) during the day significantly suppressed GRP but had little effect on AVP. Also, perfusion with the glutamate agonist NMDA, or exposure to light at night, increased GRP but did not affect AVP. These analyses reveal distinct daily rhythms of SCN peptidergic activity, with GRP but not AVP release attenuated by serotonergic activation that inhibits photic phase‐resetting, and activated by glutamatergic and photic stimulation that mediate this phase‐resetting.
Cholecystokinin (CCK)‐expressing neurons in the suprachiasmatic nucleus: innervation, light responsiveness and entrainment in CCK‐deficient mice
Authors: Hannibal Jens , Hundahl Christian , Fahrenkrug Jan , Rehfeld Jens F. , Friis‐Hansen Lennart 
Published: August 2010

AbstractThe suprachiasmatic nucleus (SCN) is the principal pacemaker driving circadian rhythms of physiology and behaviour. Neurons within the SCN express both classical and neuropeptide transmitters which regulate clock functions. Cholecyctokinin (CCK) is a potent neurotransmitter expressed in neurons of the mammalian SCN, but its role in circadian timing is not known. In the present study, CCK was demonstrated in a distinct population of neurons located in the shell region of the SCN and in a few cells in the core region. The CCK neurons did not express vasopressin or vasoactive intestinal peptide. However, CCK‐containing processes make synaptic contacts with both groups of neurons and some CCK cell bodies were innervated by VIPergic neurons. The CCK neurons received no direct input from the three major pathways to the SCN, and the CCK neurons were not light‐responsive as evaluated by induction of cFOS, and did not express the core clock protein PER1. Accordingly, CCK‐deficient mice showed normal entrainment and had similar τ, light‐induced phase shift and negative masking behaviour as wild‐type animals. In conclusion, CCK signalling seems not to be involved directly in light‐induced resetting of the clock or in regulating core clock function. The expression of CCK in a subpopulation of neurons, which do not belonging to either the VIP or AVP cells but which have synaptic contacts to both cell types and reverse innervation of CCK neurons from VIP neurons, suggests that the CCK neurons may act in non‐photic regulation within the clock and/or, via CCK projections, mediate clock information to hypothalamic nuclei.
The Diversification and Performance of Self‐Managed Superannuation Funds
Authors: Phillips Peter J. , Cathcart Alex , Teale John 
Published: August 2010

AbstractIn this article we examine the diversification and performance of a small preliminary sample of Australian self‐managed superannuation (retirement) funds (SMSFs). Using the single index model and traditional (risk‐adjusted) performance measures within the context set by modern portfolio theory we find that the SMSFs in our sample exhibit considerable under‐diversification. In addition, we find that the SMSFs do not appear to be benefiting from even naive diversification and, unsurprisingly, perform poorly on a risk‐adjusted basis vis‐à‐vis the unmanaged S&P/ASX300 index. This empirical investigation contributes to economists' understanding of the microeconomic structure of this increasingly important component of Australia's retirement income stream.
Real‐time contrast‐enhanced ultrasound determination of microvascular blood volume in abdominal subcutaneous adipose tissue in man. Evidence for adipose tissue capillary recruitment
Authors: Tobin L. , Simonsen L. , Bülow J. 
Published: August 2010

SummaryThe adipose tissue metabolism is dependent on its blood perfusion. During lipid mobilization e.g. during exercise and during lipid deposition e.g. postprandial, adipose tissue blood flow is increased. This increase in blood flow may involve capillary recruitment in the tissue. We investigated the basic and postprandial microvascular volume in adipose tissue using real‐time contrast‐enhanced ultrasound (CEU) imaging in healthy normal weight subjects. In nine subjects, CEU was performed in abdominal subcutaneous adipose tissue and in the underlying skeletal muscle after a bolus injection of ultrasound contrast agent to establish the reproducibility of the technique. In nine subjects, the effect of an oral glucose load on blood flow and microvascular volume was measured in abdominal subcutaneous adipose tissue and forearm skeletal muscle. 133Xe washout and venous occlusion strain‐gauge plethysmography was used to measure the adipose tissue and forearm blood flow, respectively. Ultrasound signal intensity of the first plateau phases was 27 ± dB in the abdominal subcutaneous adipose tissue and 18 ± 2dB (P<0·05) in the underlying skeletal muscle. The reproducibility of the measurements was good with a 4% coefficient of variation in both tissues. Blood flow and the change in signal intensity as a measure of the microvascular volume increased significantly and simultaneously in abdominal subcutaneous adipose tissue after glucose intake. The forearm blood flow and muscle signal intensity remained constant. It is concluded that the microvascular volume and changes in volume in abdominal subcutaneous adipose tissue can be assessed using CEU with good reproducibility. Postprandial capillary recruitment takes place in abdominal subcutaneous adipose tissue.
Early response to lamivudine therapy in clinically non‐cirrhotic chronic hepatitis B patients with decompensation
Authors: Dai Chia‐Yen , Yu Ming‐Lung , Hsieh Ming‐Yen , Lee LI‐Po , Hou Nai‐Jen , Huang Jee‐Fu , Chen Shinn‐Cherng , Lin Zu‐Yau , Hsieh Ming‐Yuh , Wang Liang‐Yen , Tsai Jun‐Fa , Chang Wen‐Yu , Chuang Wan‐Long 
Published: August 2010

AbstractThis study aimed to elucidate the rate and predictors of early (6 months) therapeutic responses to lamivudine, the rate of early mortality and the use of the model for end‐stage liver disease (MELD) and Index in predicting the survival in patients with a clinical diagnosis of non‐cirrhotic chronic hepatitis B with decompensation. Ninety‐eight patients with lamivudine therapy were enrolled and MELD and Index scores were calculated. Surviving patients were treated with lamivudine for more than 6 months. Four (4.1%) of the 98 patients died after initiation of lamivudine therapy. After a 6‐month lamivudine therapy, 80 (85.1%) patients and 71 (75.5%) patients had normal alanine aminotransferase (ALT) values and negative hepatitis B virus (HBV) DNA (<200 copies/mL), respectively, and hepatitis B e antigen (HBeAg)‐negative patients had a significantly higher rate of negative HBV DNA than HBeAg‐positive patients (P=0.002). The rates of HBeAg seroconversion and negative HBV DNA were 28.8 and 63.5%, respectively, and patients with HBeAg seroconversion had a significantly higher rate of negative HBV DNA (P=0.004). By multivariate analyses, older age, HBV nongenotype B infection, negative HBeAg and higher ALT levels were factors associated with negative HBV DNA, and a higher ALT level was associated with HBeAg seroconversion at month 6 after lamivudine therapy. MELD score and Index score were significantly associated with death and areas under the receiver operating characteristic curve for predicting survival were 0.936 and 0.907 respectively. We concluded that after 6‐month lamivudine therapy, the patients who survived achieved favourable biochemical, virological responses and rate of HBeAg seroconversion. Both MELD and Index scoring systems are good models to predict the 6‐month survival.
Clinicopathological improvement of non‐alcoholic steatohepatitis associated with weight loss during a 14‐year follow‐up period
Authors: Nishide Tomohiro , Ikeda Kenji , Kawamura Yusuke , Hosaka Tetsuya , Kobayashi Masahiro , Suzuki Yoshiyuki , Kumada Hiromitsu 
Published: August 2010

AbstractA 44‐year‐old woman was admitted to our hospital for investigation of persistently abnormal liver function tests. She was mildly obese and hypertensive, but not alcoholic. Laboratory studies showed high levels of aminotransferases, total cholesterol, triglycerides, hyaluronic acid and an abnormally low adiponectin level. Viral markers were negative and autoimmune liver disease was excluded. Laparoscopic and histopathological examinations were compatible with non‐alcoholic steatohepatitis (NASH), grade 1, stage 2. The patient developed diabetes 2 years after the first examination, and weight management was provided. She was admitted again to our hospital 14 years later. Her body weight had since decreased by 12 kg and laboratory studies disclosed high triglycerides, normalization of aminotransferases and adiponectin in parallel with body weight loss. Laparoscopic and histopathological examinations were compatible with NASH, grade 1, stage 0, indicating improvement relative to the first admission. We report on a case of NASH with reduction of body weight within a period of 14 years, associated with clinicopathological improvement.
Timing of ischaemia/reperfusion before hepatectomy without inflow occlusion determines liver damage in rats: role of heat shock protein 70
Authors: Nakamura Ikuo , Isaji Shuji , Yamagiwa Kentaro , Hamada Takashi , Uemoto Shinji 
Published: August 2010

AbstractBackground: Living donor hepatectomies in liver transplantation are usually performed without inflow occlusion. We hypothesized that selective ischaemia/reperfusion (SIR) before partial hepatectomy (PH) without inflow occlusion might exert a hepatoprotective effect.Methods: In the SIR groups, rats were subjected to a selective 30‐min ischaemia to the liver that remained after PH, followed by various durations of reperfusion before 70% PH without inflow occlusion. The control group underwent 70% PH alone.Results: As assessed by serum aspartate and alanine aminotransferase levels, 30‐min reperfusion was highly protective against liver injury compared with 10‐min reperfusion, showing the same levels as that of the control group. After PH in the 10‐min reperfusion group, apoptotic cells were significantly higher and the 7‐day survival rate was significantly lower than that of the 30‐min reperfusion group and the control group. In the 30‐min reperfusion group, the expression of heat shock protein 70 (HSP70) was significantly higher than that in the 10‐min reperfusion group, while apoptosis was improved to the levels of the control group. In the SIR groups, liver regeneration was significantly enhanced, with markedly increased levels of interleukin 6 (IL‐6) compared with the control group.Conclusions: The timing of SIR before PH without inflow occlusion seemed to be the most important factor for determining liver damage and survival in the context of HSP70 production, while high levels of IL‐6 appear to be associated with liver regeneration after PH. The procedure of SIR before PH is not recommended because the SIR groups did not overcome the control group.
Surveillance programme for hepatocellular carcinoma improves the survival of patients with chronic viral hepatitis
Authors: Wong Grace Lai‐Hung , Wong Vincent Wai‐Sun , Tan Guang‐Ming , Ip Ka‐Ian , Lai Wing‐Kwan , Li Yuk‐Wah , Mak Mercedes Shun‐Chi , Lai Paul Bo‐San , Sung Joseph Jao‐Yiu , Chan Henry Lik‐Yuen 
Published: August 2010

AbstractBackground: The survival benefit of surveillance for hepatocellular carcinoma (HCC) is controversial.Aim: We aimed to examine the survival benefit of HCC surveillance in chronic viral hepatitis.Methods: Survivals of HCC patients related to chronic viral hepatitis from the Hepatology Clinic (surveillance group) were compared with those referred from other hospitals/clinics (no‐surveillance group). Lead‐time and length‐time biases were adjusted based on tumour volume doubling times.Results: Among 579 patients (91% hepatitis B), 472 (82%) patients had HCC and 79 (17%) of these patients were referred from the surveillance programme. HCC was smaller (4.2 vs. 7.7 cm; P<0.001) and fewer in numbers (2.6 vs. 3.8, P=0.03) in the surveillance group vs. the no‐surveillance group. Treatment by surgery (20 vs. 10%, P=0.007) and local ablative therapy (46 vs. 19%, P<0.001) were more frequent in the surveillance group than that in the no‐surveillance group. The median survival of the surveillance group (88 weeks) was significantly longer than that of the no‐surveillance group (26 weeks) (P<0.001). The adjusted cumulative survival at 2 years was significantly longer in the surveillance group if the tumour volume doubling time was <90 days (P=0.0352).Conclusions: HCC surveillance can improve the survival of patients with chronic viral hepatitis B.
Hepatic stellate cell line modulates lipogenic transcription factors
Authors: Guimarães Eduardo L. M. , Franceschi Mariana F. S. , Andrade Cláudia M. B. , Guaragna Regina M. , Borojevic Radovan , Margis Rogério , Bernard Elena A. , Guma Fátima C. R. 
Published: August 2010

AbstractBackground/Aims: Pre‐adipocyte differentiation into adipocyte is a terminal differentiation process triggered by a cascade of transcription factors. Conversely, hepatic stellate cells (HSC) can switch between lipid storing and the myofibroblast phenotype in association with liver fibrotic processes. Here, adipogenic/lipogenic‐related transcription factors and downstream‐regulated genes were evaluated in a murine HSC cell line. GRX‐HSC cells are transitional myofibroblasts that differentiate into lipocytes following retinol or indomethacin treatment.Methods/Results: Specific mRNAs were quantified by a real‐time polymerase chain reaction after 24 h or 7 days of cell culture with indomethacin or retinol. Proliferator‐activated receptorγ and Pex16 transcripts were increased either by retinol or indomethacin. Retinol induced a minor increase in C/enhancer binding proteinα transcripts, while only indomethacin increased adipsin transcripts.Conclusions: Our results showed that the myofibroblast to lipocyte phenotype switch follows partially different transcriptional pathways, according to the effector. Retinol induces lipid synthesis and storage without affecting characteristic adipocytic genes, while indomethacin treatment restores the lipocytic phenotype with increased adipisin expression.