bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase IIB Trial of Oral Midostaurin (PKC412), the FMS-Like Tyrosine Kinase 3 Receptor (FLT3) and Multi-Targeted Kinase Inhibitor, in Patients With Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome With Either Wild-Type or Mutated FLT3
Authors: Fischer Thomas , Stone Richard M. , DeAngelo Daniel J. , Galinsky Ilene , Estey Elihu , Lanza Carlo , Fox Edward , Ehninger Gerhard , Feldman Eric J. , Schiller Gary J. , Klimek Virginia M. , Nimer Stephen D. , Gilliland D. Gary , Dutreix Catherine , Huntsman-Labed Alice , Virkus Jodi , Giles Francis J. 
Published: August 2010

Purpose Mutations leading to constitutive activation of the FMS-like tyrosine kinase 3 receptor (FLT3) occur in blasts of 30% of patients with acute myeloid leukemia (AML). Midostaurin (PKC412; N-benzoylstaurosporin) is a multitargeted tyrosine kinase inhibitor, with demonstrated activity in patients with AML/myelodysplastic syndrome (MDS) with FLT3 mutations. Patients and Methods Ninety-five patients with AML or MDS with either wild-type (n = 60) or mutated (n = 35) FLT3 were randomly assigned to receive oral midostaurin at 50 or 100 mg twice daily. The drug was discontinued in the absence of response at 2 months, disease progression, or unacceptable toxicity. Response was defined as complete response, partial response (PR), hematologic improvement, or reduction in peripheral blood or bone marrow blasts by ≥ 50% (BR). Results The rate of BR for the population in whom efficacy could be assessed (n = 92) was 71% in patients with FLT3-mutant and 42% in patients with FLT3 wild-type. One PR occurred in a patient with FLT3-mutant receiving the 100-mg dose regimen. Both doses were well-tolerated; there were no differences in toxicity or response rate according to the dose of midostaurin. Conclusion These results suggest that midostaurin has hematologic activity in both patients with FLT3-mutant and wild-type. The degree of clinical activity observed supports additional studies that combine midostaurin and other agents such as chemotherapy especially in FLT3-mutant AML.
Die mittelalterlichen jüdischen Grabsteine und Gemeindeeinrichtungen in der Stadt Spandau
Authors: Pohl Joachim 
Published: August 2010

Abstract
The Jewish community of Spandau ranks among the oldest in the medieval Margraviate of Brandenburg. The Jews were probably settled in Spandau at a very early stage of urban development by archbishop Wichmann of Magdeburg at the end of the 12th century. A gravestone from 1244 suggests the existence of a cemetery and thus of a Jewish community. It was covered over by the castle of the Brandenburg margraves and prince-electors in Spandau and has been excavated along with about 70 further tombstones in restorations since the 1950s. Besides describing the Jewish immigration at Spandau, the article examines the synagogue and the cemeteries. The displacement of the Brandenburg Jewry due to the Hostienschändungsprozess [Host desecration charges] of 1510 brought the history of the Spandau Jewish community to an end. The cemeteries were cleared and the gravestones used as building material for the castle and in the later citadel of Spandau. Today, these unique monuments constitute one of the largest collections of medieval Jewish tombstones in Germany and the most important material remains of the Jewry in the medieval Margraviate of Brandenburg.
Jüdische Spitäler in Österreich-Ungarn um 1900
Authors: Malleier Elisabeth 
Published: August 2010

Abstract
Early Hekdeshim did not distinguish between the housing of the poor, travelling strangers, old and sick people. At the end of the 18th and the beginning of the 19th century Jewish hospitals with explicit medical intentions and with 30 to 40 beds were built in cities with large Jewish communities such as Budapest, Vienna, Krakow, Trieste, Chernivtsi and Lviv. Besides, there also existed small hospitals and »Siechenhäuser« for old and chronically ill people in smaller communities. They were often funded by donations of wealthy persons and by community taxes and administrated by the Chevra Kadisha, the Jewish burial societies. With the exception of the Jewish hospital in Prague all institutions were privately run. In Austro-Hungary, the building of big modern hospitals with 100 beds and more began during the last two decades of the 19th century (Budapest 1889, Vienna 1893) and continued through the turn of the century (Lviv and Prague) until the 1920s and 1930s (Chernivtsi, Krakow, Pozsony). At the same time, the old and small hospitals continued to exist, especially in regions with poor Jewish communities such as Galicia and Eastern Hungary.
Meta-communicative signals and humorous verbal interchanges: A case study
Authors: Canestrari Carla 
Published: August 2010

AbstractThe aim of this article is to provide a system for analysis of verbal humorous interactions that incorporates both the General Theory of Verbal Humor and the meta-communicative level. The integration will be accomplished using a two-pronged analytical model of humorous interactions. According to the General Theory of Verbal Humor, the first phase will trace the humor in the text with particular attention given to the Script Opposition and to the Logical Mechanism; the second will monitor the meta-communicative level, focusing on meta-communicative signals. Information about the humorous frame constitutes a seventh Knowledge Resource, called Meta-Knowledge Resource. Applying this model to an Italian film starring the comic actor Totò produced two results: 1) the definition of two kinds of humor on- and off-stage depending on the presence of Meta-Knowledge Resource and 2) a description of the “ideal author” postulated by the text. The second result is achieved by an analysis that combines on- and off-stage humor with verbal and referential humor.
Immunogenicity and Safety of 13-Valent Pneumococcal Conjugate Vaccine in Infants and Toddlers
Authors: Yeh Sylvia H. , Gurtman Alejandra , Hurley David C. , Block Stan L. , Schwartz Richard H. , Patterson Scott , Jansen Kathrin U. , Love Jack , Gruber William C. , Emini Emilio A. , Scott Daniel A. ,   on behalf of the 004 Study Group
Published: August 2010

BACKGROUND:
7-Valent pneumococcal conjugate vaccine (PCV7 [Prevnar, Wyeth Pharmaceuticals Inc, Philadelphia, PA], serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F) is effective in preventing vaccine-serotype pneumococcal disease. 13-Valent pneumococcal conjugate vaccine (PCV13) (PCV7 serotypes plus 1, 3, 5, 6A, 7F, and 19A) was designed to provide broader pneumococcal disease coverage. We evaluated the immunogenicity and safety of PCV13 compared with PCV7.

METHODS:
Infants received PCV13 or PCV7 at ages 2, 4, 6, and 12 to 15 months with routine pediatric vaccinations. Pneumococcal anticapsular polysaccharide-binding immunoglobulin G responses and functional antipneumococcal opsonophagocytic activity were assessed 1 month after dose 3, before the toddler dose, and 1 month after the toddler dose. Safety and tolerability were also assessed.

RESULTS:
For the 7 common serotypes, PCV13-elicited immunoglobulin G titers were noninferior to those elicited by PCV7, although PCV13 responses were generally somewhat lower. PCV13 also elicited functional opsonophagocytic activity comparable with that elicited by PCV7. For the 6 additional serotypes in PCV13, PCV13 elicited binding and functional antibody levels notably greater than those in PCV7 recipients. After PCV13 immunization, concordance between antipolysaccharide and opsonophagocytic responses was noted for all 13 serotypes. The PCV13 toddler dose resulted in higher immune responses compared with infant-series doses. Safety and tolerability were comparable; reactogenicity was generally mild.

CONCLUSIONS:
PCV13 will be as effective as PCV7 in the prevention of pneumococcal disease caused by the 7 common serotypes and could provide expanded protection against the 6 additional serotypes. The PCV13 safety profile was comparable to that of PCV7.
Use of Spanking for 3-Year-Old Children and Associated Intimate Partner Aggression or Violence
Authors: Taylor Catherine A. , Lee Shawna J. , Guterman Neil B. , Rice Janet C. 
Published: August 2010

OBJECTIVES:The objective of this study was to examine associations between maternal and paternal use of corporal punishment (CP) for 3-year-old children and intimate partner aggression or violence (IPAV) in a population-based sample.METHODS:The study sample (N = 1997) was derived from wave 3 of the Fragile Families and Child Wellbeing Study. Mother and father reports regarding their use of CP and their IPAV victimization were analyzed. IPAV included coercion and nonphysical and physical aggression.RESULTS:Approximately 65% of the children were spanked at least once in the previous month by 1 or both parents. Of couples who reported any family aggression (87%), 54% reported that both CP and IPAV occurred. The most prevalent patterns of co-occurrence involved both parents as aggressors either toward each other (ie, bilateral IPAV) or toward the child. The presence of bilateral IPAV essentially doubled the odds that 1 or both parents would use CP, even after controlling for potential confounders such as parenting stress, depression, and alcohol or other drug use. Of the 5 patterns of co-occurring family aggression assessed, the “single aggressor” model, in which only 1 parent aggressed in the family, received the least amount of empirical support.CONCLUSIONS:Despite American Academy of Pediatrics' recommendations against the use of CP, CP use remains common in the United States. CP prevention efforts should carefully consider assumptions made about patterns of co-occurring aggression in families, given that adult victims of IPAV, including even minor, nonphysical aggression between parents, have increased odds of using CP with their children.
Variations in Timing of Surgery Among Boys Who Underwent Orchidopexy for Cryptorchidism
Authors: Kokorowski Paul J. , Routh Jonathan C. , Graham Dionne A. , Nelson Caleb P. 
Published: August 2010

OBJECTIVE:Current clinical guidelines recommend that orchidopexy be performed by the age of 1 in patients with congenital undescended testis. We sought to examine trends in surgical timing and to determine what factors are associated with age at surgery.METHODS:The Pediatric Health Information System (PHIS) is a national database of &gt;40 freestanding children's hospitals. We searched the PHIS to identify boys with cryptorchidism who underwent orchidopexy between 1999 and 2008. Patient age at orchidopexy was evaluated, and we used multivariate models to determine factors associated with timing of surgery.RESULTS:We identified 28 204 children who underwent orchidopexy at PHIS hospitals. Of these, 14 916 (53%) were white, and 17 070 (61%) had public insurance. Only 5031 patients (18%) underwent orchidopexy by the age of 1 year; only 12 165 (43%) underwent orchidopexy by the age of 2 years. These figures remained stable over time (P = .32). After adjusting for patient clustering, race (P &lt; .001) and insurance status (P &lt; .001) remained associated with patient age at orchidopexy; however, the treating hospital (P &lt; .001) was the most important factor in predicting the timing of the procedure.CONCLUSIONS:Only 43% had surgery by 2 years of age, which suggests that either significant numbers of boys with congenital cryptorchidism do not undergo surgery in a timely fashion or late-onset testicular ectopy is more common than generally recognized. Factors associated with the timing of orchidopexy include patient race, insurance status, and the hospital in which surgery is performed.
Effect of Platelet-Rich Plasma on Peri-Implant Bone Repair: A Histologic Study in Dogs
Authors: Garcia Ricardo V. , Gabrielli Marisa A. Cabrini , Hochuli-Vieira Eduardo , Spolidorio Luis C. , Filho Joao G. Padilha , Neto Francisco A. Doria , de Cardoso Luciana A. Gouveia , Shibli Jamil A. 
Published: August 2010

AbstractThe present study evaluated the effect of platelet-rich plasma (PRP) on peri-implant bone healing. A total of 9 mongrel dogs received 36 dental implants with sandblasted acid-etched surface in lower jaws in a split-mouth design: in the PRP group (n  =  18 implants) the implants were placed in association with PRP, and in the control group (n  =  18 implants) the implants were placed without PRP. Biopsies were obtained and prepared for histologic and histometric analysis after 15, 30, and 55 days of healing. The biopsies retrieved at 15 days showed delicate bone trabeculae formed by immature bone with presence of numerous osteoblasts for both groups. At 30 days the trabeculae presented reversal lines and evident lamellar disposition, where some thread spaces were filled by bone and dense connective tissue. At 55 days, bone healing was not altered in the control group, and histologic aspects were variable for the group treated with PRP. There was no significant difference between the groups for bone-to-implant contact (P &gt; .05). PRP did not enhance bone formation around sandblasted acid-etched implants.
Profile of Neonatal sepsis
Authors: Khinchi YR , Kumar Anit , Yadav Satish 
Published: August 2010

Objective: To study the clinical presentation, investigational profile and outcome of neonatal sepsis in general and with special reference to inborn (intramural) or out born (extramural), sex and weight of the neonate. Materials and method: Retrospective descriptive study of neonates admitted during 2 years from July 2007 to June 2009 in special care neonatal unit of the department of Pediatrics, College of Medical Sciences-Teaching Hospital, Bharatpur, Nepal. Results: Majority of neonates were out born and referred (72.2%) to this institution. Significant number of babies was having sepsis in out born group (59%) as compared to inborn (35%). Male sex was found to have more sepsis as compared to female. Sepsis was observed to be inversely related to birth weight, 65% in low birth weight (LBW, <2.5Kg) as compared to 42.6% in normal birth weight group (> 2.5kg). Conclusions: High index of suspicion for diagnosis of neonatal sepsis is required especially in the presence of risk factors. Prevalence of sepsis is inversely related to birth weight. More number of out born delivered babies developed sepsis. Neonatal sepsis related morbidity and mortality can be significantly reduced by comprehensive obstetric and neonatal care at multiple levels right from community to health institutions. Key words: Neonatal sepsis; Inborn; Out born; Low birth weight (LBW). DOI: 10.3126/jcmsn.v6i2.3609 Journal of college of Medical Sciences-Nepal, 2010, Vol.6, No-2, 1-6
A phylogeny and classification of the Muhlenbergiinae (Poaceae: Chloridoideae: Cynodonteae) based on plastid and nuclear DNA sequences
Authors: Peterson Paul M. , Romaschenko Konstantin , Johnson Gabriel 
Published: August 2010

• Premise of the study: To understand the origins of C4 grasslands, we must have a better interpretation of plant traits via phylogenetic reconstruction. Muhlenbergiinae, the largest subtribe of C4 grasses in Mexico and the southwestern United States (with 176 species), is taxonomically poorly understood.• Methods: We conducted a phylogenetic analysis of 47 genera and 174 species using six plastid regions (ndhA intron, ndhF, rps16‐trnK, rps16 intron, rps3, and rpl32‐trnL) and the nuclear ITS 1 and 2 (ribosomal internal transcribed spacer) regions to infer evolutionary relationships and revise the classification.• Key results: In our analyses, Muhlenbergia (ca. 153 species) is paraphyletic, with nine genera (Aegopogon, Bealia, Blepharoneuron, Chaboissaea, Lycurus, Muhlenbergia, Pereilema, Redfieldia, Schaffnerella, and Schedonnardus) found nested within. We recognized the following five well‐supported monophyletic lineages within Muhlenbergia: subg. Muhlenbergia, with species that have phosphoenolpyruvate carboxykinase‐like leaf anatomy and long, scaly rhizomes; subg. Trichochloa with long‐lived species that are relatively tall (up to 3 m); subg. Clomena with 3‐nerved upper glumes; sect. Pseudosporobolus species with narrow panicles and plumbeous spikelets; and sect. Bealia species with lemmas with hairy margins and midveins.• Conclusions: We propose expanding the circumscription of Muhlenbergia to include the other nine genera in this subtribe and make the following new combinations: Muhlenbergia subg. Bealia, M. diandra, M. geminiflora, M. paniculata, M. phleoides, M. subg. Pseudosporobolus (also lectotipified), M. solisii, M. tricholepis. We also propose several new names: M. ammophila, M. columbi, M. plumosa. Our phylograms suggest that Muhlenbergia originated in North America because the sister (Sohnsia filifolia and Scleropogoninae) is composed of predominantly North American species.
Statu quo autour d'un squat
Authors: Coutant Isabelle 
Published: August 2010

Résumé L’enquête menée sur un squat situé dans le nord de Paris permet à la fois de montrer comment s’adaptent des représentants de l’État confrontés à des situations dont la gestion publique n’est pas clairement explicitée et d’étudier « les formes de gestion privée » (celles des associations de quartier) qui se donnent pour fonction de suppléer les pouvoirs publics jugés défaillants : symptôme de la dégradation d’un quartier, le squat focalise en effet le sentiment d’abandon et de déclassement des habitants. Dans la même perspective, cette enquête permet aussi d’analyser les stratégies mises en œuvre par les occupants du squat pour agir sur les jugements à leur égard.
La gestion des rendez-vous dans un service médical spécialisé
Authors: Cicourel Aaron V. 
Published: August 2010

Résumé L’article traite les pratiques organisationnelles et discursives durant des aspects ordinaires mais souvent négligés de la prestation de soins médicaux : les problèmes d’organisation du temps dans un service médical spécialisé. Un problème typique survient lorsque les patients ne se présentent pas et que beaucoup de temps (et d’argent) est perdu, ou lorsqu’un patient doit être « glissé » dans un planning déjà surchargé de traitements et de rendez-vous confirmés. Ceci implique de consacrer moins de temps aux patients et/ou de les faire attendre plus longtemps. Pour les organisations de santé (Health Maintenance Organizations, HMO) aux États-Unis, l’absence aux rendez-vous peut perturber les procédures bureaucratiques car le service des rendez-vous peut se trouver géographiquement éloigné de l’unité de soins médicaux. Le personnel de bureau peut appeler d’autres patients pour remplacer les rendez-vous annulés. Enfin, cet article discute l’idée de « surcharge cognitive » au cours d’expériences personnelles et interpersonnelles de tension sur le lieu de travail, par exemple lorsque les exigences des tâches attribuées au personnel excèdent leur capacité à y répondre « en douceur » ou sans effort à l’aide des ressources qui sont à leur disposition immédiate. L’idée de « surcharge cognitive » permet de comprendre comment, dans des conditions de travail où la collaboration est difficile, des stratégies discursives et motrices sont nécessaires pour répondre aux besoins organisationnels qui pèsent sur les ressources individuelles et collectives.
Paradoxes d'une médicalisation coloniale
Authors: Monnais-Rousselot Laurence 
Published: August 2010

Résumé L’histoire de l’École de médecine de Hanoi, qui ouvre ses portes en 1902, révèle plusieurs aspects marquants du processus de professionnalisation du médecin indigène dans le Vietnam (Indochine française) de la première moitié du xx e siècle. Pour autant, aucun historique de cette institution coloniale modèle, devenue faculté de médecine en trois décennies, ne suffirait à traduire les ambiguïtés de ce processus, leurs raisons d’être et leur héritage. C’est bien d’abord à l’évolution de la législation autour du médecin indochinois et au regard des textes métropolitains concernant la profession médicale en France mais aussi aux signes de légitimation sur le terrain, en particulier au travers de la pratique au quotidien et de la reconnaissance scientifique d’un certain nombre de praticiens qu’il faut se rapporter pour identifier le véritable contenu de ce mouvement complexe. Ce travail de traduction met alors en évidence des réalités inhérentes au contexte de colonisation et au maintien d’un rapport dominant-dominé ; il permet en parallèle de poser un regard renouvelé sur quelques traits distinctifs du professionnel de santé vietnamien après 1945 et en particulier son rôle majeur dans la définition, la défense et la pratique d’une médecine nationale syncrétique et dans la construction d’un système de santé dual reposant sur de nouvelles ambivalences.
Fabriquer une culture nationale
Authors: Shavit Zohar 
Published: August 2010

Résumé La littérature étrangère traduite en hébreu a joué un rôle majeur dans la construction d’une littérature nationale, conçue comme partie intégrante d’une culture hébraïque laïque et moderne, en Palestine au début du xx e siècle. La culture hébraïque devait offrir une alternative à la société juive traditionnelle en fondant son identité sur d’autres bases que la tradition et le patrimoine religieux. Loin d’être perçue comme une greffe étrangère, la littérature traduite en hébreu a été mobilisée, tant par les dirigeants politiques que par les écrivains et les éditeurs, dans l’entreprise de création du patrimoine littéraire d’une société impliquée dans un processus de construction nationale. Deux motivations principales expliquent ce rapport positif à la littérature traduite : d’une part, la volonté de constituer un public de lecteurs en hébreu en Palestine, et, d’autre part, celui de proposer à ce public un catalogue varié de manière à satisfaire tous ses besoins, y compris dans le domaine des belles-lettres, et notamment en littérature classique.
La vocation au travail de traduction
Authors: Kalinowski Isabelle 
Published: August 2010

Résumé Subjectivement vécue comme un privilège et une garantie d’autonomie, la traditionnelle solitude du traducteur et son statut d’« ouvrier à domicile » constituent un modèle pour le fonctionnement actuel du secteur de l’édition, qui a aujourd’hui recours à plus de 40 % de non-salariés ponctuellement affectés à des tâches payées en droits d’auteur. La propension des traducteurs à vivre leur métier comme une « vocation » transfigure leur ascétisme en signe d’élection. Regroupés dans une association et non dans un syndicat, ils sont divisés par un clivage entre traducteurs à temps plein et universitaires traducteurs qui hiérarchise l’accès au patrimoine littéraire le plus noble (qui est aussi masculinisé). Mais l’exacerbation de cet antagonisme tient surtout au fait qu’ils ont en commun dans bien des cas des capitaux scolaires élevés qui n’ont pas été assortis des mêmes profits sociaux, et ne doit pas dissimuler qu’ils partagent une même vocation à ne pas « se faire un nom ».
Le Crédit mutuel
Authors: Moulévrier Pascale 
Published: August 2010

Résumé Le Crédit mutuel, fondé en pratique sur l’encadrement et la gestion de l’épargne populaire, devient, au cours du vingtième siècle, une banque coopérative et mutualiste. Le codage d’emblée religieux, plus précisément catholique, de l’activité conduit l’institution à créer continûment une relation bancaire singulière où se mêlent dénégation du profit et morale socio-éducative de l’acte marchand. Aujourd’hui le Crédit mutuel, en contrepartie de son immersion plus nette dans le système libéral capitaliste, pérennise, sur le terrain des « grandes causes » sociales et en accord avec une tradition chrétienne du rapport dénié au marché, « son » identité mutualiste. Pour autant la banque ne trouve pas seulement en elle-même les conditions de sa reconversion. Comprendre les logiques de cette institution c’est aussi interroger les enjeux propres au champ bancaire français, voire européen, que constituent notamment les places financières et symboliques à prendre et à tenir.