bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect Of The Medication And Food Monitoring Program (Mfmp) On Anemia In Pregnant Women
Authors: Nuroni Nuroni , Yantina Yuli , Isnaini Nurul , Kurniasari Devi 
Published: April 2024

Latar Belakang: Anemia dianggap sebagai faktor risiko dan dapat mengakibatkan komplikasi yang mengancam kehidupan ibu dan janin . Program Pemantau Minum Obat Dan Makanan merupakan program yang bertanggung jawab dalam mengawasi ibu hamil dalam mengkonsumsi obat serta makanan yang diperbolehkan.Tujuan: Mengetahui pengaruh Program Pemantau Minum Obat Dan Makanan terhadap anemia pada ibu hamil di Puskesmas Pinang Jaya Tahun 2023.Metode: Desain yang digunakan dalam penelitian ini adalah pre-eksperimental. Populasi pada penelitian ini adalah semua ibu hamil di Puskesmas Pinang Jaya Tahun 2023. Variabel independen adalah Program Pemantau Minum Obat Dan Makanan dan variabel dependen adalah kadar Hb Pengumpulan data menggunakan lembar observasi. Analisis data menggunakan uji T Independen.Hasil: skor pengetahuan sebelum (tidak PMOM) yaitu 10.175, dan standar deviasi .5475. Sedangkan rerata pengetahuan sesudah (tidak PMOM) yaitu 10.204, dan standar deviasi .5507 dari 56 responden . Sedangkan rerata skor pengetahuan sebelum (PMOM) yaitu 10.114, dan standar deviasi .7006 .Sedangkan rerata pengetahuan sesudah (PMOM) yaitu 10.514, dan standar deviasi .6047 dari 56 responden.Kesimpulan: Ada pengaruh PMOM terhadap anemia pada ibu hamil.Saran: Bagi Puskesmas Pinang Jaya diharapkan dapat memberikan informasi yang berguna bagi pihak puskesmas dalam membuat kebijakan yang berkaitan dengan pencegahan anemia pada ibu hamil. Kata kunci : PMOM, Anemia, Ibu Hamil ABSTRACT Background: Anemia is considered a risk factor and can lead to complications that threaten the life of the mother and fetus. The Medication and Food Monitoring Program (MFMP) is a program that is responsible for supervising pregnant women in consuming permitted drugs and food.Objective: To determine the effect of the Medication and Food Monitoring Program on anemia in pregnant women at the Pinang Jaya Health Center in 2023.Methods: The design used in this study was pre-experimental. The population in this study were all pregnant women at the Pinang Jaya Health Center in 2023. The independent variable was the Medication and Food Monitoring Program and the dependent variable was Hb levels. Data collection used an observation sheet. Data analysis used the Independent T test.Results: Knowledge score (not MFMP) is 10.175, and standard deviation is 0.5475. While the average knowledge after (not MFMP) is 10.204, and the standard deviation is 0.5507 from 56 respondents. Meanwhile, the mean score of prior knowledge (MFMP) was 10.114, and the standard deviation was 0.7006. Meanwhile, the average post knowledge (MFMP) was 10.514, and the standard deviation was 0.6047 from 56 respondents.Conclusion: There is an effect of MFMP on anemia in pregnant women.Suggestion: It is hoped that the Pinang Jaya Community Health Center can provide useful information for the community health center in making policies related to the prevention of anemia in pregnant women. Keywords: MFMP, Anemia, Pregnant Women
ІСТОРИЧНИЙ ШЛЯХ ГУМАНІТАРНОГО ІНСТИТУТУ НАЦІОНАЛЬНОГО УНІВЕРСИТЕТУ ОБОРОНИ УКРАЇНИ (1991–2023 рр.)
Authors: ТАЛАУР Сергій , ПОГОРЄЛОВ Андрій 
Published: April 2024

У статті розглянуто історію заснування, становлення та розвитку гуманітарного інституту Націо­нального університету оборони України, розкрито основні напрями його діяльності та науково-педагогічні здобутки. Розроблено наукову періодизацію історичного шляху гуманітарного інституту, що складаєься з трьох етапів. Перший етап (організаційний) розпочався в листопаді 1991 р. зі створення робочої групи для розроблення концепції підготовки офіцерів з виховної роботи і завершився комплектуванням інституту постійним складом у липні 1994 р. Було розроблено концептуальні засади підготовки офіцерів з виховної роботи, введено в дію постійний штат інституту, розгорнуто його основні підрозділи, здійснено добір кадрів та розпочато навчальний процес з 1 вересня 1994 р. Під час другого етапу інститут функціонував як самостійний заклад системи вищої військової освіти аж до його входження у серпні 1999 р. до складу Націо­нальної академії оборони України у статусі Військового гуманітарного інституту. Під час цього етапу розгорнуто діяльність усіх факультетів інституту, активний розвиток отримали освітня та наукова компоненти. Після входження інституту до складу Націо­нальної академії оборони України (з 2013 р. — Націо­нального університету оборони України) тривав третій етап, який завершився у жовтні 2023 р. розформуванням гуманітарного інституту. В ході цього етапу гуманітарний інститут досягнув вагомих результатів у підготовці фахівців для Збройних Сил та інших складових сил оборони держави.
PREDICTING THE LEARNING PATH TO LEARNER’S OPTIMUM COMPREHENSION
Authors: Achi Ifeanyi Isaiah , Agwu Chukwuemeka Odi , Nnamene Christopher Chizoba , Aniobi Sylvester C. , Barnabas C. Ifebude , Oketa Kelechi Christian , Ezeh Godson Kenechukwu , Ugah John Otozi 
Published: April 2024

The essence of learning is for the learner to attain a significant level of comprehension after the learning process is completed. The quest to achieve this singular purpose has led to the introduction of several learning techniques in the conventional learning environment, such as asking questions and conducting test after class, just to mention a few. Additionally, technology has been introduced in learning. Even with technological advancements, the learning experience still faces the challenge of learners not attaining the optimum comprehension state after the learning process. This is due to the present systems' inability to model the learner to determine the best methods for achieving maximum comprehension. Hence, this research paper focuses on deriving an improved mathematical model for predicting the learning path to a learner’s optimum comprehension. The paper presented three learning instructional media (learning paths); textual, audio and a hybrid of audio and video, which this research uses in modelling the learner. This is to enable the improved system predict the best learning path to optimum comprehension for learners. This research paper adopted Reinforcement Learning and the Markov decision process, specifically the Markov Chain approach, in developing an improved model for prediction. The evaluation of this research involved brainstorming on the Bellman’s equation with the aid of the Markov Chain transition state framework, resulting in an improved mean value function of 71.7. This indicates an enhanced comprehension state for the learning students compared to the existing mean value function of 46.0. The results obtained from this research clearly demonstrate that the improved model was able to predict and assign the best learning path to achieve optimum comprehension state for learners.
ГОТОВНІСТЬ УЧИТЕЛІВ ГЕОГРАФІЇ СПЕЦІАЛЬНИХ ШКІЛ СЛОВАЦЬКОЇ РЕСПУБЛІКИ ДО ВИКОРИСТАННЯ ЕЛЕКТРОННОГО ДИДАКТИЧНОГО ПОСІБНИКА З IT-ПІДТРИМКОЮ
Authors: Гладуш Віктор , Ковачова Барбора , Бендікова Славка , Чарницька Марцела 
Published: April 2024

The purpose of the article is to highlight the level of readiness of teachers of geography of special schools of the Slovak Republic (on the example of 14 of special and inclusive education institutions of the Košice Region) to the use of an electronic didactic manual on IT support. Teachers of the Department of Special Pedagogy of the Pedagogical Faculty of the Catholic University in Ruzomberok together with teachers of the geography of special schools prepared an electronic didactic manual on IT support taking into account modern requirements to the level of knowledge, abilities and psychophysical capabilities of school children with special education needs. The manual has helped to raise the level of geographical learning among school children of special school. The convincing results of the pedagogical experiment are described in the previous article «Using a didactic tool with IT-support for teaching geography in a special school in Slovakia». However, in the course of studying the question the researchers concluded that success in the work depends on the level of readiness of the teacher for this work. Namely, the presence of interest and motivation to the introduction of innovative forms of training for the subjects of the education process the attitude of the teacher to the organization of the education process, the level of professional training (possession of the means and technologies of training). To obtain objective and unbiased results Google Form has conducted a survey of teachers of geography. The first set of questions – the reference one – provided an opportblocky to explain the answers of the second set of questions – the informative one. The statistical processing of the survey results supports the assumption that the quality of the IT-supported e-manual is largely dependent on the teacher’s readiness. The results also show that the majority of teachers of geography surveyed are well aware of the benefits of this teaching tool and are now ready to put the manual into practice. However, due to the rapid progress in the use of information and communication technologies the teachers of special schools do not deny the need to improve their professional knowledge of the use of ICT in postgraduate teacher training.
THE MEMOIRS OF ERAST NUDATOV AS A SOURCE OF SHEVCHENKO’S BIOGRAPHY OF RAIM PERIOD (1848—1849)
Authors: Boron Oleksandr 
Published: April 2024

The paper aims to evaluate the reliability of Erast Nudatov’s memoirs who was an ensign of the fourth linear battalion of the Separate Orenburg Corps at the time of his acquaintance with Shevchenko. The memoirs were recorded by the Russian journalist and writer Dmitry Klemensov, whose real surname was Montvid. Due to the lack of other sources for reconstructing the conditions of the Aral Sea Expedition’s stay in Raim in 1848—1849, D. Klemensov’s publication repeatedly attracted close attention from researchers. However, many of them have been overly credulous toward the information it contains. Some of Klemensov’s assumptions had no factual basis and led to the spread of several legends in Shevchenko studies, primarily concerning references to Shevchenko’s artistic works (now unknown). Shevchenko did not draw any political caricatures, let alone “obscene pictures.” It seems that due to the limited memories of E. Nudatov, D. Klemensov had to largely speculate on a number of episodes, depicting Shevchenko as involved in various incidents occuring in the Raim fortress or those heard by the ensign during his service.
The information provided by E. Nudatov has been cross-checked with documents, reliable memoirs, etc. The journalist’s treatment of his story turned out to be too fictionalized, not least because of the publisher’s financial interest. It is indicative that the editorial board of the “Kiievskaia Starina” journal, known for its commitment to preserving the poet’s memory, did not publish the proposed material. Perhaps this was due to doubts about its authenticity or disagreement about the terms of publication.
In conclusion, it is advisable to only use an information from D. Klemensov’s material, confirmed by other sources. The rest of the stories, in particular those about Shevchenko’s antics, which are definitely too many for the three months of the exile’s and the ensign’s joint stay in Raim, should be used with great caution, bearing in mind the low reliability of these memoirs.
Pengaruh Video Animasi terhadap Perilaku Pencegahan COVID-19 pada Anak Sekolah Dasar
Authors: Yanti Farah Sevnell , Hanum Fathiya Juwita , Firdawati Firdawati , Rahmadian Rizki , Amir Arni , Nurhajjah Siti 
Published: April 2024

Pendahuluan: Coronavirus Disease (COVID-19) merupakan penyakit infeksi virus SARS-CoV-2 yang menyerang sistem pernapasan manusia. Penyakit ini memiliki tingkat penularan yang tinggi sehingga diperlukan upaya pencegahan untuk menghambat penularannya. Anak sekolah dasar termasuk kelompok yang berisiko menjadi carrier dan menularkan virus ini kepada orang lain meskipun tidak bergejala. Promosi kesehatan pada kelompok ini penting dilakukan melalui media penyampaian informasi yang menarik agar mereka menyadari pentingnya melakukan upaya pencegahan penyakit COVID-19. Tujuan penelitian: Untuk melihat pengaruh video animasi tentang pencegahan COVID-19 terhadap pengetahuan, sikap, dan tindakan siswa sekolah dasar kelas 3-5 SDN 10 Lambung Bukit Padang. Metode: Ini adalah penelitian analitik menggunakan pre experimental design dengan one-group pretest-posttest design. Terdapat sebanyak 52 sampel siswa SDN 10 Lambung Bukit Padang. Data diambil menggunakan kuesioner dan dianalisis dengan uji wilcoxon signed rank test. Hasil: Sebelum dilakukan intervensi mayoritas sampel memiliki tingkat pengetahuan yang kurang (48,1%), sikap yang baik (61,5%) dan tindakan yang baik (75,0%). Setelah diberikan intervensi, mayoritas memiliki tingkat pengetahuan yang cukup (57,7%), sikap yang baik (84,6%) dan tindakan yang baik (84,6%). Hasil analisis bivariat pre dan post intervensi menggunakan Uji Wilcoxon mendapatkan nilai p-value < 0,05 untuk variabel pengetahuan, sikap, dan tindakan. Hal ini menunjukkan setelah dilakukan intervensi terdapat perubahan yang bermakna (signifikan) dari pengetahuan, sikap, dan tindakan responden tentang pencegahan COVID-19. Kesimpulan: Terdapat pengaruh video animasi tentang pencegahan COVID-19 terhadap pengetahuan, sikap, dan tindakan siswa sekolah dasar kelas 3-5 SDN 10 Lambung Bukit.
Berbagai Tanaman di Indonesia untuk Tabir Surya
Authors: Nazifah Fauzana , Yenny Satya Widya 
Published: April 2024

Indonesia adalah salah satu negara dengan paparan sinar matahari yang tinggi dan sebagian besar penduduknya bekerja diluar ruangan sehingga memerlukan suatu perlindungan kulit. Sinar matahari selain memberi manfaat juga mempunyai dampak buruk pada kulit jika terpapar secara berlebihan. Sinar ultraviolet UVB dan UVA bekerja secara sinergis merusak kulit sehingga dibutuhkan pencegahan atau perlindungan untuk mengurangi dampak buruk pada kulit akibat radiasi tersebut. Jika paparan sinar matahari berlebihan, jaringan epidermis kulit tidak mampu sepenuhnya melawan efek negatif sehingga diperlukan perlindungan, salah satunya dengan tabir surya. Tabir surya merupakan pelindung kulit dari paparan sinar matahari karena ikatan yang saling berkonjugasi sehingga ikatan tersebut beresonansi saat terpapar sinar UV dan akan menurunkan energi untuk melindungi kulit. Tabir surya memiliki dua mekanisme kerja yaitu secara fisik dengan memantulkan dan membiaskan sinar UV yang mengenai kulit dan secara kimia dengan cara menyerap sinar UV yang dipancarkan oleh matahari. Pada daun tumbuhan terdapat zat alami yang dapat diekstrak dan dapat bertindak sebagai sumber potensial tabir surya karena bersifat fotoprotektif. Daun-daunan seperti daun kersen, daun cempedak dan daun binahong mempunyai kemampuan untuk melindungi kulit melalui senyawa yang terkandung di dalam tanaman yang berupa senyawa bioaktif seperti senyawa fenolik dan didukung oleh adanya senyawa yang bersifat antioksidan.
Carcinoma Endometrioid Ovary pada Struma Ovarii
Authors: Muhammad Syamel , Antonius Puja Agung , Meuthia Susan , Savannah Aisha 
Published: April 2024

Kanker ovarium merupakan penyebab utama kematian pada wanita yang didiagnosis sebagai kanker ginekologi. Tingginya angka kematian akibat kanker ovarium karena mayoritas kasus bersifat asimptomatik dan skrining yang dilakukan untuk menegakkan diagnosis masih kurang. Hal ini menyebabkan kanker ovarium dikenal sebagai silent killer. Etiologi spesifik kanker ovarium hingga belum diketahui dengan pasti, namun teradapat beberapa faktor risiko yang berperan terhadap terjadinya kanker ovarium. Faktor risiko genetik diduga berkaitan erat dengan kejadian kanker ovarium, diantaranya mutasi pada gen TP53, BRCA1 dan BRCA2. Diagnosis kanker ovarium sulit dilakukan pada stadium dini karena tidak adanya gejala spesifik. Untuk menegakkan diagnosis kanker ovarium dibutuhkan anamnesis, pemeriksaan fisik dan pemeriksaan penunjang seperti CT scan, USG, pemeriksaan tumor marker dan biopsi. Hingga saat ini, pembedahan masih menjadi penatalaksanaan utama bagi kanker ovarium. Pemeriksaan histopatologi juga perlu dilakukan untuk menentukan keganasan, jenis kanker, dan penentuan staging. Kemoterapi adjuvan diberikan pada pasien setelah pembedahan, kecuali jika penyakit hanya terbatas pada ovarium dan pada kanker yang tidak bisa dioperasi. Prognosis kanker ovarium bergantung dari jenis kanker, stadium dan komplikasi yang terjadi. Pada jurnal ini dilaporkan kasus seorang pasien perempuan, berusia 59 tahun dengan carcinoma endometrioid ovary pada struma ovarii.
Peptidomics-based identification of antihypertensive and antidiabetic peptides from sheep milk fermented using Limosilactobacillus fermentum KGL4 MTCC 25515 with anti-inflammatory activity: in silico, in vitro, and molecular docking studies
Authors: Pipaliya Rinkal , Basaiawmoit Bethsheba , Sakure Amar A. , Maurya Ruchika , Bishnoi Mahendra , Kondepudi Kanthi Kiran , Singh Brij Pal , Paul Souparno , Liu Zhenbin , Sarkar Preetam , Patel Ashish , Hati Subrota 
Published: April 2024

This study investigated the synthesis of bioactive peptides from sheep milk through fermentation with Limosilactobacillus fermentum KGL4 MTCC 25515 strain and assessed lipase inhibition, ACE inhibition, α-glucosidase inhibition, and α-amylase inhibition activities during the fermentation process. The study observed the highest activities, reaching 74.82%, 70.02%, 72.19%, and 67.08% (lipase inhibition, ACE inhibition, α-glucosidase inhibition, and α-amylase inhibition) after 48 h at 37°C, respectively. Growth optimization experiments revealed that a 2.5% inoculation rate after 48 h of fermentation time resulted in the highest proteolytic activity at 9.88 mg/mL. Additionally, fractions with less than 3 kDa of molecular weight exhibited superior ACE-inhibition and anti-diabetic activities compared to other fractions. Fermentation of sheep milk with KGL4 led to a significant reduction in the excessive production of NO, TNF-α, IL-6, and IL-1β produced in RAW 267.4 cells upon treatment with LPS. Peptides were purified utilizing SDS-PAGE and electrophoresis on 2D gels, identifying a maximum number of proteins bands ranging 10–70 kDa. Peptide sequences were cross-referenced with AHTPDB and BIOPEP databases, confirming potential antihypertensive and antidiabetic properties. Notably, the peptide (GPFPILV) exhibited the highest HPEPDOCK score against both α-amylase and ACE.
Genetically predicted lipids mediate the association between intrahepatic cholestasis of pregnancy and cardiovascular disease
Authors: Cui Ji , Zhai Qilong , Chen Mengjie , Yang Zhu 
Published: April 2024

IntroductionIntrahepatic cholestasis of pregnancy (ICP), the most prevalent liver disorder specific to pregnancy, affects approximately 1.5%-4% of pregnancies. However, the influence of ICP on cardiovascular disease (CVD), including hypertension (HTN) and coronary artery disease (CAD), has not been thoroughly investigated.MethodsThis study explores the causal relationship between ICP and CVD (HTN, CAD) using Mendelian Randomization (MR). Utilizing summary-level data from Genome-Wide Association Studies (GWAS), we applied the inverse-variance weighted (IVW) method, supplemented by sensitivity and reverse MR analyses, to ascertain robustness.ResultsOur findings reveal significant causal links, indicating ICP notably increases the risk of CVD (P = 0.001), hypertension (HTN, P = 0.024), and coronary artery disease (CAD, P = 0.039). A two-step MR analysis highlighted the mediation role of lipid profiles, with LDL, TC, and Apo-B contributing to increased CVD risk by 25.5%, 12.2%, and 21.3%, respectively. Additionally, HTN was identified as a mediator in the ICP-CAD association, accounting for a 14.5% mediation effect.DiscussionThe results underscore the genetic predisposition of ICP to elevate CVD risk and the critical mediating role of lipid levels, emphasizing the need for vigilant lipid monitoring and early intervention in individuals with ICP.
Effects of transcutaneous electrical acupoint stimulation on early postoperative pain and recovery: a comprehensive systematic review and meta-analysis of randomized controlled trials
Authors: Tan Shi-Yan , Jiang Hua , Ma Qiong , Ye Xin , Fu Xi , Ren Yi-Feng , You Feng-Ming 
Published: April 2024

BackgroundPrevious studies have indicated beneficial outcomes of transcutaneous electrical acupoint stimulation (TEAS), but high-quality and comprehensive meta-analyses are lacking. The aim was to quantitatively analyze the efficacy and safety of perioperative TEAS on postoperative pain and recovery.MethodsPubMed, Web of Science, EMBASE, and the Cochrane Library were searched through July 2022. Randomized controlled trials (RCTs) that examined the perioperative application of TEAS in adults compared with sham-TEAS and/or non-TEAS were eligible. Cumulative analgesic consumption within 24 h and rest pain scores at 2, 6, 12, and 24 h postoperatively were the two co-primary outcomes.ResultsSeventy-six RCTs (n = 9,665 patients) were included. Patients treated with TEAS experienced a reduction in clinical importance in cumulative analgesic (morphine equivalent) consumption (WMD: −14.60 mg, 97.5% CI: −23.60 to −5.60; p &lt; 0.001) and a reduction in statistical importance in rest pain scores at multiple time points within the first 24 postoperative hours. The secondary outcome analysis also identified clinically significant recovery benefits to TEAS during the first 24 h after surgery. Furthermore, TEAS could effectively reduce opioid-related side effects and did not increase serious side effects.ConclusionThis article describes current evidence about TEAS intervention on early postoperative pain and recovery. The results support the effectiveness of TEAS, but more high-quality evidence of clinical applicability is also needed.Systematic review registrationPROSPERO (CRD42021249814).
Enhancing fetal outcomes in GCK-MODY pregnancies: a precision medicine approach via non-invasive prenatal GCK mutation detection
Authors: Schwitzgebel Valérie M. , Blouin Jean-Louis , Dehos Barbara , Köhler-Ballan Bettina , Puder Jardena J. , Rieubland Claudine , Triantafyllidou Maria , Zanchi Anne , Abramowicz Marc , Nouspikel Thierry 
Published: April 2024

BackgroundMutations in the GCK gene cause Maturity Onset Diabetes of the Young (GCK-MODY) by impairing glucose-sensing in pancreatic beta cells. During pregnancy, managing this type of diabetes varies based on fetal genotype. Fetuses carrying a GCK mutation can derive benefit from moderate maternal hyperglycemia, stimulating insulin secretion in fetal islets, whereas this may cause macrosomia in wild-type fetuses. Modulating maternal glycemia can thus be viewed as a form of personalized prenatal therapy, highly beneficial but not justifying the risk of invasive testing. We therefore developed a monogenic non-invasive prenatal diagnostic (NIPD-M) test to reliably detect the transmission of a known maternal GCK mutation to the fetus.MethodsA small amount of fetal circulating cell-free DNA is present in maternal plasma but cannot be distinguished from maternal cell-free DNA. Determining transmission of a maternal mutation to the fetus thus implies sequencing adjacent polymorphisms to determine the balance of maternal haplotypes, the transmitted haplotype being over-represented in maternal plasma.ResultsHere we present a series of such tests in which fetal genotype was successfully determined and show that it can be used to guide therapeutic decisions during pregnancy and improve the outcome for the offspring. We discuss several potential hurdles inherent to the technique, and strategies to overcome these.ConclusionOur NIPD-M test allows reliable determination of the presence of a maternal GCK mutation in the fetus, thereby allowing personalized in utero therapy by modulating maternal glycemia, without incurring the risk of miscarriage inherent to invasive testing.