bluuebunny/crossref_metadata_2025_split huggingface dataset:
Matematyczny model nieustalonego przepływu mieszaniny wodoru i gazu ziemnego w rurociągu
Authors:   Państwowa Akademia Nauk Stosowanych im. Ignacego Mościckiego w Ciechanowie, Gburzyńska Marta 
Published: April 2024

"W niniejszym artykule opisany został matematyczny model przepływu gazu w stanie nieustalonym, który następnie został uzupełniony do postaci prezentującej matematyczny model mieszaniny wodoru i gazu ziemnego. Model ten jest wyprowadzany za pomocą równań ruchu, ciągłości oraz stanu i dostarcza precyzyjnego opisu dynamicznych aspektów przepływu gazu. Badania matematyczne obejmują dodanie wodoru do gazu ziemnego, mając na celu umożliwienie zrozumienia wpływu tej modyfikacji na właściwości mieszaniny gazów. Model matematyczny mieszaniny gazów jest linearyzowany w celu zapisu w postaci operatorowej. Postać operatorowa modelu daje możliwość między innymi definicji funkcji przejścia. Funkcje przejścia definiowane są w celu badania reakcji wejście–wyjście. Po przekształceniu do postaci operatorowej funkcje przejścia są wykorzystywane do badania właściwości dynamicznych układu. Kolejnym etapem jest opis funkcji przejścia w postaci widmowej, aby zbadać właściwości dynamiczne rurociągu z wykorzystaniem analizy częstotliwościowej. Charakterystyki częstotliwościowe opisują zachowanie układu w stanie ustalonym przy sygnałach sinusoidalnych. Wyrażają relację między odpowiedzią układu a zadanym wymuszeniem harmonicznym, zmieniającym się w określonym zakresie prędkości kątowej. Charakterystyki częstotliwościowe w skali logarytmicznej przedstawione oddzielnie dla modułu liczby określającej stosunek amplitudy sygnału wyjściowego do amplitudy sygnału wejściowego oraz logarytmicznej charakterystyki fazowej, czyli zależności przesunięcia fazowego od prędkości kątowej przedstawionej w skali logarytmicznej, nazywane są charakterystykami Bodego. Charakterystyki Bodego pozwalają analizować, jak dla określonych wartości prędkości kątowej sygnału wejściowego zmieniają się amplituda oraz przesunięcie fazy między sygnałem wyjściowym a wejściowym. Podstawowym celem przeprowadzonej analizy jest zrozumienie procesów przepływu gazu w warunkach nieustalonych. Jednym z kluczowych parametrów branym pod uwagę jest stosunek masowy wodoru do gazu ziemnego, oznaczany jako θ. Ten współczynnik ma decydujące znaczenie dla zrozumienia właściwości mieszaniny gazów. Daje on cenne informacje na temat dynamiki mieszanki. Wpływ tej mieszaniny na procesy przepływu gazu jest istotny zarówno teoretycznie, jak i praktycznie. Prezentowana analiza stanowi istotny krok w kierunku lepszego zrozumienia tych procesów.
Penanggulangan Terhadap Kejahatan Cyber-Terrorism Melalui Politik Hukum Pidana
Authors: Alfendo Yefta Argastya  
Published: April 2024

Abstract
The research aims to construct a rule of law in order to tackle cyber-terrorism crimes in Indonesia. In essence, changes in technological developments have a positive impact in the framework of increasing human welfare, progress and civilization, but these technological and information developments also have a negative impact. One of them is a crime using computer and internet media known as cybercrime. This study uses normative legal research and statutory, conceptual, and comparative approaches. Whereas the results of the study show that compared to other countries, Indonesia has experienced delays in regulating legal formulations regarding cybercrime, especially cyber-terrorism. In addition, law enforcement is also experiencing ambiguity because there is no instrument that regulates clearly and unequivocally. In this context, Indonesia must use the politics of criminal law to compile and regulate cyber-terrorism crimes in the context of overcoming cybercrimes. Therefore, the government must immediately make regulations or draft laws to anticipate cyber-terrorism crimes.

Abstrak
Penelitian bertujuan untuk mengonstruksi sebuah aturan hukum dalam rangka menanggulangi kejahatan cyber-terrorism di Indonesia. Pada hakikatnya perubahan dalam perkembangan teknologi berdampak positif dalam rangka peningkatan kesejahteraan, kemajuan, dan peradaban manusia, namun perkembangan teknologi dan informasi ini juga berdampak negatif. Salah satunya adalah tindak kejahatan yang menggunakan media komputer dan internet yang dikenal dengan istilah kejahatan mayantara atau cybercrime. Penelitian ini menggunakan penelitian hukum normatif dan pendekatan perundang-undangan, konseptual, dan perbandingan. Bahwa hasil penelitian menunjukkan Jika dibandingkan dengan negara lain maka Indonesia mengalami keterlambatan dalam mengatur formulasi hukum mengenai cybercrime terkhusus cyber-terrorism. Selain itu penegakan hukum juga mengalami ketidakjelasan karena belum ada instrumen yang mengatur secara jelas dan tegas. Dalam konteks ini Indonesia harus menggunakan politik hukum pidana guna menyusun dan mengatur mengenai kejahatan cyber-terrorism dalam rangka penanggulangan kejahatan dunia maya. Oleh karena itu pemerintah harus segera membuat aturan atau rancangan undang-undang untuk mengantisipasi kejahatan cyber-terrorism.
Gagasan Directive Principle of State and Social Policy Model Brasil Sebagai Sistem Perencanaan Pembangunan Indonesia dalam PPHN
Authors: Kurniati Mulqiyah  , Muhammad Anugerah Perdana  , Septika Nanda Arifia  
Published: April 2024

Abstract
The National Development Planning System (SPPN) is currently being discussed by the People's Consultative Assembly (MPR) not to be continued and to be replaced with the Principles of State Policy (PPHN). Currently, the mechanism to be used in PPHN is still being debated, one of which is the idea of using the Directive Principle State and Social Policy (DPSP) method which is being implemented in Brazil. This research uses normative juridical methods with legislative, comparative and historical approaches. The results of this research provide two conclusions. First, development planning using mechanisms such as GBHN or SPPN cannot be used as a mechanism in PPHN. Second, the Brazilian model of DPSP is very suitable to be applied in Indonesia because of 2 (two) things, firstly the 1945 Constitution of the Republic of Indonesia which adopts socialism and constitutionalism; second, the adoption of a 3 (three) chamber parliamentary model (tricameral system).

Abstrak
Sistem Perencanaan Pembangunan Nasional (SPPN) saat ini tengah diwacanakan Majelis Permusyawaratan Rakyat (MPR) untuk tidak dilanjutkan dan akan digantikan dengan Pokok-pokok Haluan Negara (PPHN). Saat ini, mekanisme yang akan dipakai dalam PPHN masih menjadi perdebatan, salah satunya adalah gagasan untuk menggunakan metode Directive Principle State and Social Policy (DPSP) yang diimplementasikan di Brasil. Penelitian ini menggunakan metode yuridis normative dengan pendekatan peraturan perundang-undangan, komparatif, dan historis. Hasil dari penelitian ini memberikan dua kesimpulan. Pertama, perencanaan pembangunan dengan mekanisme seperti GBHN maupun SPPN tidak dapat dijadikan sebagai mekanisme dalam PPHN. Kedua, DPSP model Brasil sangatlah cocok diterpakan di Indonesia dikarenakan 2 (dua) hal, pertama konstitusi UUD NRI 1945 yang mengadopsi paham sosialisme dan konstitusionalisme; kedua, dianutnya model parleme 3 (tiga) kamar (sistem tricameral).
Analisis Pengaturan Living Law dalam RUU KUHP yang Dituangkan pada Peraturan Daerah Ditinjau Berdasarkan Konstitusi
Authors: Aisha Nurul Fadilla  , Defa An Nuur Kusumajakti  , Rangga Maulana Fauzi  
Published: April 2024

Abstract
The Draft Criminal Code Law (RUU KUHP) is a reformation of the criminal Code left behind with the aid of the Dutch East Indies colonial generation which became no longer in accordance with existence in society. Within the regulatory layout, residing law turns into an issue or new component that is accommodated as an implementation of the growth of the legality precept that is anticipated in order to assist law enforcement which is felt to be greater simply and bring continuity between (UU and residing law). That is realized through the existence of regional regulations as an expansion of the principle of legality which in its scope regulates the compilation of customary criminal offenses. However, this is felt to be inconsistent with Article 18B paragraph (2) of the 1945 constitution which regulates the recognition and appreciate for customary law and conventional rights. The inclusion of residing law preparations in regional regulations causes regulations regarding respect and also the conventional rights of Indigenous Peoples

Abstrak
Rancangan Undang-Undang Kitab Undang-Undang Hukum Pidana (RUU KUHP) merupakan pembaharuan KUHP peninggalan zaman kolonial Hindia Belanda dimana sudah tidak sesuai lagi dengan kehidupan yang ada di masyarakat. Dalam rancangan pengaturannya, living law menjadi sebuah isu ataupun hal baru yang diakomodir sebagai implementasi perluasan asas legalitas yang digadang-gadang dapat membantu penegakan hukum yang dirasa lebih adil dan membawa kesinambungan antara (UU dan living law). Hal tersebut diwujudkan dengan adanya Peraturan Daerah sebagai perluasan asas legalitas yang dalam cakupannya mengatur tentang kompilasi Delik pidana adat. Namun, hal tersebut dirasa tidak sejalan dengan Pasal 18B ayat (2) Undang- Undang Dasar 1945 yang mana mengatur mengenai pengakuan serta penghormatan hukum adat dan hak-hak tradisional. Dimasukkannya pengaturan living law dalam Peraturan Daerah menyebabkan adanya pembatasanpembatasan mengenai penghormatan dan juga hak-hak tradisional Masyarakat Hukum Adat.
Pengenalan Computer Vision Berbasis Convolutional Neural Network melalui Dewatalks
Authors: Juliandy Carles , Darwin Darwin 
Published: April 2024

The meaning of computer vision itself is to create how computers can see and understand what they see, just like humans perceive things. Some applications of computer vision around us include the use of face sensors by mobile devices to unlock phones, the use of cameras in public places to support electronic traffic tickets, and many other applications. However, in daily life, many people are still not aware of the implementation of computer vision around us. Therefore, in this community service, computer vision with the CNN algorithm is introduced to the public to better understand the potential that can be generated from computer vision. The results of this community service have achieved the initial goal of introducing computer vision to the community. Feedback from participants also indicates that 3 participants were very dissatisfied, 4 participants were dissatisfied, 14 participants were neutral, 54 participants were satisfied, and 18 participants were very satisfied. Based on the feedback provided by the participants, future advanced training will be conducted with a longer duration and more in-depth material in each session.

Abstrak
Makna dari computer vision sendiri adalah membuat bagaimana komputer dapat melihat dan memahami apa yang dilihat sama seperti manusia melihat sesuatu. Beberapa pemanfaatan computer vision di sekitar kita seperti penggunaan sensor wajah oleh perangkat ponsel untuk membuka kunci ponsel, pemanfaatan kamera di tempat umum untuk mendukung e-tilang, dan masih banyak pemanfaatan lainnya. Akan tetapi dalam keseharian, masih banyak masyarakat yang belum mengenali adanya penerapan computer vision di sekitar kita. Oleh karena ini pada pengabdian kali ini diperkenalkan computer vision dengan algoritma CNN ini kepada masyarakat untuk dapat lebih memahami potensi yang dapat dihasilkan dari computer vision. Hasil dari pengabdian ini mencapat tujuan yang sudah ditetapkan di awal yaitu mengenalkan computer vision kepada masyarakat. Feedback dari peserta juga menunjukkan bahwa peserta yang merasa sangat tidak puas sebanyak 3 orang, kurang puas sebanyak 4 orang, biasa saja 14 orang, puas 54 orang, sangat puas 18 orang. Berdasarkan feedback yang sudah diberikan oleh para peserta kedepannya akan dilakukan pelatihan lanjutan dengan durasi yang lebih panjang dan materi yang lebih mendalam di setiap pelatihannya.
The bacterial metabolite, lithocholic acid, has antineoplastic effects in pancreatic adenocarcinoma
Authors: Mikó Edit , Schwarcz Szandra , Kovács Patrik , Nyerges Petra , Ujlaki Gyula , Sipos Adrienn , Uray Karen , Bai Peter 
Published: April 2024

Abstract

Lithocholic acid (LCA) is a secondary bile acid. LCA enters the circulation after bacterial synthesis in the gastrointestinal tract, reaches distantly located cancer cells, and influences their behavior. LCA was considered carcinogenic, but recent studies demonstrated that LCA has antitumor effects. We assessed the possible role of LCA in pancreatic adenocarcinoma. At the serum reference concentration, LCA induced a multi-pronged antineoplastic program in pancreatic adenocarcinoma cells. LCA inhibited cancer cell proliferation and induced mesenchymal-to-epithelial (MET) transition that reduced cell invasion capacity. LCA induced oxidative/nitrosative stress by decreasing the expression of nuclear factor, erythroid 2-like 2 (NRF2) and inducing inducible nitric oxide synthase (iNOS). The oxidative/nitrosative stress increased protein nitration and lipid peroxidation. Suppression of oxidative stress by glutathione (GSH) or pegylated catalase (pegCAT) blunted LCA-induced MET. Antioxidant genes were overexpressed in pancreatic adenocarcinoma and decreased antioxidant levels correlated with better survival of pancreatic adenocarcinoma patients. Furthermore, LCA treatment decreased the proportions of cancer stem cells. Finally, LCA induced total and ATP-linked mitochondrial oxidation and fatty acid oxidation. LCA exerted effects through the farnesoid X receptor (FXR), vitamin D receptor (VDR), and constitutive androstane receptor (CAR). LCA did not interfere with cytostatic agents used in the chemotherapy of pancreatic adenocarcinoma. Taken together, LCA is a non-toxic compound and has antineoplastic effects in pancreatic adenocarcinoma.
Mer receptor expression promotes multiple myeloma disease development via a cell-extrinsic mechanism
Authors: Clark Justine R. , Panagopoulos Vasilios , Noll Jacqueline E. , Mrozik Krzysztof M. , Bradey Alanah L. , Croucher Peter I , Zannettino Andrew C. W. , Vandyke Kate , Hewett Duncan R. 
Published: April 2024

Abstract

Multiple myeloma (MM) is an incurable haematological malignancy characterised by the uncontrolled proliferation of bone marrow resident plasma cells (PCs). Two members of the TAM (TYRO3, AXL and MER) receptor family have previously been implicated in distinct aspects of neoplastic PC biology. AXL expression in MM PCs has been associated with induction of a dormant, non-cycling state within the bone marrow, whereas expression of MER has been implicated in PC proliferation and survival. Here, generation of single TAM receptor expressing 5TGM1 murine MM cell lines enabled the individual functional assessment of the effects of Axl and Mer receptor expression on MM development. Axl expression did not affect proliferation, cell cycling, or stromal cell induced dormancy in vitro. Development of 5TGM1 tumours in C57BL/KaLwRij mice was also unaltered by Axl expression. By contrast, Mer expression conferred an increase in cell proliferation to 5TGM1 cells in vitro, and increased 5TGM1 tumour burden in C57BL/KaLwRij mice. The pro-tumourigenic properties of Mer were only observed following intravenous cell delivery into mice with an intact adaptive immune system. Thus, Axl is neither necessary nor sufficient for induction of MM cancer cell dormancy, whereas Mer remains a promising target for therapeutic intervention in MM patients.
Reconciling tracked atmospheric water flows to close the global freshwater cycle
Authors: De Petrillo Elena , Fahrländer Simon , Tuninetti Marta , Andersen Lauren S. , Monaco Luca , Ridolfi Luca , Laio Francesco 
Published: April 2024

Abstract

Atmospheric moisture plays a vital role in the hydrological cycle, connecting evap oration sources to precipitation sinks. While high-resolution moisture-tracking models offer valuable insight, discrepancies to atmospheric re-analysis data emerge. In this study, we reconcile tracked atmospheric water flows with reanal ysis data, using the Iterative Proportional Fitting procedure (IPF). We apply IPF to the atmospheric moisture flows from the UTrack dataset (averaged over 2008-2017), aggregated within countries and ocean boundaries. This reconciled dataset ensures that the total tracked atmospheric moisture equals the total precipitation at the sink and evaporation at the source on an annual basis. Country-scale discrepancies of up to 275% in precipitation and 225% in evapo ration are amended, correcting fluxes by 0˜.07%, on average. We find 45% of the total terrestrial precipitation (˜1.5 ·105 km3yr−1) originates from land evaporation (9.8 ·104 km3yr−1). Our reconciled country-scale dataset offers new ground to investigate transboundary atmospheric water flows which connect us globally.
Transcriptome Analysis of Salicylic Acid Manipulates Watermelon Immune System Against FON Infection
Authors: Yang kankan , Wang Ruozhong , Fang Yong , Zou Ting , Peng Xiaoyun , Wang Zhiwei , Zhu Feiying 
Published: April 2024

Abstract

Watermelon fusarium wilt is a soil-borne disease that seriously affects watermelon yield. Our previous study found that salicylic acid (SA) plays an essential role in regulating watermelon roots against the Fusarium wilt (FW), but the molecular mechanism is still unclear. Therefore, in this experiment, we aim to explore the molecular mechanism of SA to manipulate disease resistance of the watermelon immune system based on transcriptome analysis, combined with chlorophyll fluorescence images, phytohormone content quantification, and RT‒qPCR verification. Our results demonstrated that exogenous SA activates watermelon plants against Fon1 infection at 3 dpi by inducing other phytohormones and enriching resistance genes to maintain the citrate cycle. Comparing analysis of differentially expressed genes (DEGs) identified that the CIPER10, CIMYB59, CIMYB44, CIPYL4, CIAGP31, and CIACO3 have key functions in SA signal transduction to active watermelon immune responses. The bioinformatics analysis indicated that SA has a cooperating network with abscisic acid (ABA), jasmonic acid (JA), and ethylene (ET) to manipulate the watermelon immune system against FW. Collectively, our findings provide significant insight into watermelon FW defense mechanisms and information for the breeding of new watermelon cultivars.
Talking Technology Tutors: The Perceptions of Conversational AI in Education Through the Eyes of Parents and Teachers Worldwide
Authors: Otermans Pauldy Cornelia Johanna , Baines Stephanie , Livingstone Chelsea , Aditya Dev 
Published: April 2024

Abstract

As artificial intelligence becomes an increasingly prevalent tool across society, conversations have begun on whether it should be implemented into education. Teachers and parents are at the forefront of this dilemma, their opinions being an integral part of the ongoing discussion. This study explores parents’ and teachers’ perspectives on the uses of conversational AI in education. Survey results (111 parents, 109 teachers) showed that the majority of parents and teachers believed conversational AI could support their child’s/students’ development, they were likely to use conversational AI for their child/student, and were comfortable with their child/students using it. In addition, there was a moderate amount of apprehension from both parents and teachers toward AI in education to due privacy, plagiarism and lack human contact concerns. To conclude, parents and teachers had an overall positive view of implementing conversational AI into education.
Genetic diversity and population structure analysis of 418 tomato cultivars based on SNP markers
Authors: Xu Weijie , Gong Chao , Mai Peiting , Li Zhenxing , Sun Baojuan , Li Tao 
Published: April 2024

Abstract

Tomato (Solanum lycopersicum) is a highly valuable fruit crop. However, due to the lack of scientific and accurate variety identification methods and nationally unified standards, scattered and non-standardized management in production has led to mixed varieties that have caused significant difficulties in the cataloging and preservation of germplasm resources and the identification, promotion, and application of new tomato varieties. In order to better understand the genetic diversity and population structure of representative tomato varieties, we have collected a total of 418 representative tomato varieties in the past 20 years and analyzed them based on genome-wide single nucleotide polymorphism (SNP) markers. In this study, we evaluated the population structure, genetic relationships, and genetic fingerprints of 418 germplasm resources of tomatoes using simplified genome sequencing technology. A total of 196,612,427 single nucleotide polymorphisms (SNPs) were identified. Furthermore, 418 samples of tomatoes were divided into six subgroups, and the population structure and genetic relationships among existing tomato germplasm resources were determined using principal component analysis, population structure analysis, and phylogenetic tree analysis. Through several stringent selection criteria, 15 additional streamlined, high-quality DNA fingerprints were filtered out of the validated 50 SNP loci and verified as being able to effectively identify the 418 tomato varieties. Among them, 46 SNP loci were successfully converted into KASP markers. In general, this study marks the first comprehensive investigation that measures the diversity and population structure of a substantial collection of tomato varieties. These results have greatly broadened our understanding of the diversity, phylogeny, and population structure of tomato germplasm resources. The results may provide a scientific basis and reference data for the future analysis of genetic diversity, species identification, property rights disputes, and molecular breeding in tomatoes.
RRM2: a crosstalk gene for COVID-19 and intervertebral disc degeneration revealed by integrated WGCNA and machine learning
Authors: Cai Changxiong , Liu Jiahao , Yang Guoyu , Miao Xinxin , Wu Tianlong , Cheng Xigao 
Published: April 2024

Abstract

Background: Intervertebral disc degeneration (IDD) is a major cause of low back pain (LBP), and COVID-19 has been reported to be an important risk factor for IDD. The aim of this study was to explore the molecular mechanisms underlying the effects of COVID-19 on IDD by identifying overlapping crosstalk genes associated with these two conditions. The identification of crosstalk genes between COVID-19 and IDD patients will have important clinical implications for early intervention in COVID-19 secondary IDD.
Methods: The gene expression profiles of GSE157103 and GSE70362 were extracted from the GEO database. These profiles were then subjected to analysis using WGCNA, Lasso, and SVM-RFE, resulting in the identification of RRM2 as a crosstalk gene for both COVID-19 and IDD. Additionally, GSEA was employed to investigate the potential mechanisms by which RRM2 exerts its effects in disease. Furthermore, a relationship between RRM2 and immune cells was revealed through correlation analysis. Finally, independent external datasets (GSE171110 and GSE146904) were utilized to validate the diagnostic efficacy of RRM2.
Results: The crosstalk gene RRM2 for both COVID-19 and IDD was identified through the application of WGCNA and machine learning algorithm. GSEA analysis further revealed that RRM2 participates in fatty acid metabolism, thereby promoting disc degeneration in IDD. Moreover, immunocorrelation analyses unveiled a negative regulatory role of RRM2 in CD56-bright natural killer cells and its induction of IDD disc degeneration.
Conclusions: A crosstalk gene of COVID-19 and IDD, RRM2, was identified using WGCNA and machine learning algorithm, providing a new perspective for exploring possible mechanisms of secondary IDD in COVID-19.