bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction by genetic MATS of 4CMenB vaccine strain coverage of invasive meningococcal serogroup B isolates circulating in Taiwan between 2003 and 2020
Authors: Muzzi Alessandro , Lu Min-Chi , Mori Elena , Biolchi Alessia , Fu Tiffany , Serino Laura 
Published: May 2024

ABSTRACT

Neisseria meningitidis
serogroup B (NmB) strains have diverse antigens, necessitating methods for predicting meningococcal serogroup B (MenB) vaccine strain coverage. The genetic Meningococcal Antigen Typing System (gMATS), a correlate of MATS estimates, predicts strain coverage by the 4-component MenB (4CMenB) vaccine in cultivable and non-cultivable NmB isolates. In Taiwan, 134 invasive, disease-causing NmB isolates were collected in 2003–2020 (23.1%, 4.5%, 5.2%, 29.8%, and 37.3% from individuals aged ≤11 months, 12–23 months, 2–4 years, 5–29 years, and ≥30 years, respectively). NmB isolates were characterized by whole-genome sequencing and vaccine antigen genotyping, and 4CMenB strain coverage was predicted using gMATS. Analysis of phylogenetic relationships with 502 global NmB genomes showed that most isolates belonged to three global hyperinvasive clonal complexes: ST-4821 (27.6%), ST-32 (23.9%), and ST-41/44 (14.9%). Predicted strain coverage by gMATS was 62.7%, with 27.6% isolates covered, 2.2% not covered, and 66.4% unpredictable by gMATS. Age group coverage point estimates ranged from 42.9% (2–4 years) to 66.1% (≤11 months). Antigen coverage estimates and percentages predicted as covered/not covered were highly variable, with higher estimates for isolates with one or more gMATS-positive antigens than for isolates positive for one 4CMenB antigen. In conclusion, this first study on NmB strain coverage by 4CMenB in Taiwan shows 62.7% coverage by gMATS, with predictable coverage for 29.8% of isolates. These could be underestimated since the gMATS calculation does not consider synergistic mechanisms associated with simultaneous antibody binding to multiple targets elicited by multicomponent vaccines or the contributions of minor outer membrane vesicle vaccine components.

IMPORTANCE

Meningococcal diseases, caused by the bacterium
Neisseria meningitidis
(meningococcus), include meningitis and septicemia. Although rare, invasive meningococcal disease is often severe and can be fatal. Nearly all cases are caused by six meningococcal serogroups (types), including meningococcal serogroup B. Vaccines are available against meningococcal serogroup B, but the antigens targeted by these vaccines have highly variable genetic features and expression levels, so the effectiveness of vaccination may vary depending on the strains circulating in particular countries. It is therefore important to test meningococcal serogroup B strains isolated from specific populations to estimate the percentage of bacterial strains that a vaccine can protect against (vaccine strain coverage). Meningococcal isolates were collected in Taiwan between 2003 and 2020, of which 134 were identified as serogroup B. We did further investigations on these isolates, including using a method (called gMATS) to predict vaccine strain coverage by the 4-component meningococcal serogroup B vaccine (4CMenB).
10: ADJUSTMENT THE BEST STRATEGIES TO NEW EVIDENCE-BASED TEACHING: NEED TO CHANGE AND PROSPECTIVE FOR FUTURE
Authors: Taghipour Nikta , mosalanejad leili , Javdani Farshid , abdollahifard Saeed 
Published: May 2024

Background and aims:Evidence-based teaching has the potential to promote processing in learners that leads to better transfer of skills and knowledge to the workplace and contributes to the emergence of adaptive expertise. Research shows that evidence-based teaching strategies are likely to have the largest impact on student results. In this article we have tried to adapt evidence-based teaching with SPICES model and explore some the appropriate strategies to teaching evidence-based curriculum. Also we addressed some the new method of teaching that is adjustable to these strategies in teaching and learning in evidence- based curricula.Methods:This study covers the period of 2007–2013. Researches were done initially by single keywords and using OR/AND, for combining words such as: evidence-based education, teaching methods, teaching strategies, Spices strategies for identify publications from SID, IRANMEDEX, MAGIRAN, OVID, PROQUET, CINAHL, Google scholar, web of sciences and PubMed databases. A total of 309 publications were found, from which, after excluding duplication and non-related papers, only 28 publications were considered relevant to the subject and were examined thoroughly.Results:The best strategies which are considerable in teaching evidences- based content include: Clear Lesson Goals, Show & Tell, questioning to check for understanding, summaries new learning in a graphical way, practice makes perfect, Provide Your Students with Feedback, Be Flexible About How Long It Takes to Learn, Get Students Working Together and se meta-cognition. These strategies are adjustable to SPICES pattern in designing curriculum in medical education in some part as student's center, community based education, problem based learning that can be present in new method of teaching and learning such as team based, problem based, case based learning and so on.Conclusion:It is the responsibility of the academic institutions and policy-makers in medical education to provide condition that promotes evidence-based strategies and adjust to teaching method. It decreases the gap between theory and practice and it also promotes the quality of teaching- learning process in evidence-based contents.
104: QUALITY OF SLEEP AND DAILY ACTIVITY OF THE ELDERLY IN ZANJAN
Authors: Salimi Sedigeh , Pakpour Vahid , Hosseiny Raziehsadat 
Published: May 2024

Background and aims:Poor quality of sleep and daily activity in elderly people are associated with many physical and psychological problems that increase disability and need to use health services. The aim of this study was to determine the relationship between daily activities and quality of sleep in the elderly people.Methods:This Study was a correlational-descriptive study on390 elderly people in Zanjan in 2013. The sampling was done using a cluster and multistage method. Data were collected via face-to-face interview, using Pittsburgh Sleep Quality Index (PSQI) and a questionnaire on “activities of daily living” (ADL) and “instrumental activities of daily living” (IADL). Data analysis was performed using descriptive statistic including number, percentage, mean, standard deviation, and inferential statistical tests including Spearman's rank correlation coefficient, independent t-test and one-way analysis of variance.Results:The mean score of ADL and IADL was 11.58±0.81 (score range 0–14) and 11.23±2.93 (score range 0–18), respectively. In addition, 85.7%of the subjects in the study had poor sleep quality and only 14.3% had good sleep quality. The results also indicated no significant relationship between the daily activities and quality of sleep in the elderly, while Instrumental activities had a weak positive and significant correlation with their sleep quality (P≥0.05).Conclusion:Although the elderly in this study have poor sleep quality, they are independent in performing ADL and IADL. Furthermore, there is a weak and direct correlation between sleep quality and instrumental activities of the old people. Improvement of activity in the elderly can improve their quality of sleep.
105: RELATIONSHIP BETWEEN ANTENATAL AND POSTPARTUM DEPRESSION WITH WEIGHT RETENTION 1 YEAR AFTER CHILDBIRTH
Authors: Pourmehr Hanieh Salehi , Farshbafkhalili Azizeh , Mohammadi Fatemeh , Malakouti Jamileh , Rafiee Somayyeh , Abdi Mozhgan , Jafarilar Nayyer 
Published: May 2024

Background and aims:Prevalence of Obesity among childbearing age women has increased markedly in recent decades, and it has become a major health problem with probably impact on mental health of obese women. For many women, returning to prepregnancy weight is a challenge. This study performed to examine the extent to which trimesters of pregnancy and early postpartum depression is associated with weight retention 1 year after childbirth.Methods:In a prospective cohort study of 307 women enrolled in Project with title “association between prepregnancy BMI and postpartum depression”, 62 women with class 2 and 3 of obesity and 245 with normal prepregnancy BMI, reported depressive symptoms on the Edinburgh Postnatal Depression Scale (EPDS) at 1st, 2nd and 3rd trimesters of pregnancy and 6-8 weeks postpartum. A score >13 indicated probable depression. Associations between antenatal and postpartum depression with risk of substantial weight retention (at least 5 kg) 1 year after childbirth were assessed.Results:One hundred and forty nine women (76.8%) with normal prepregnancy BMI were not depressed during or after pregnancy, while these amounts were 22 women (47.8%) in obese group. 32 (16.5%) in normal BMI and 7 women (15.2%) in obese group experienced antenatal depression only, 5 (2.6%) in normal group and 6 (13.0%) in obese group experienced postpartum depression only and 8 (4.1%) in normal group and 11 women (23.9%) in obese group experienced both antenatal and postpartum depression (p<0.001). At 1 year, participants retained a mean of 2.52 kg (range −10 to 17) in normal BMI group and 18.1% retained at least 5 kg and in obese group slightly decrease was shown: −0.02 kg (range −14 to 12) with 11.1% with retained weight at least 5 kg. Binary logistic regression analyses, after adjustment for weight-related covariates, maternal sociodemographics, and parity, antenatal and postpartum depression showed antenatal depression, either alone or in combination with postpartum depression, was not associated with substantial weight retention (odds ratio (OR): 1.02, 95% confidence interval (CI): 0.94, 1.10).Conclusion:The results showed that obese women are most prone to have postpartum depression. However there was no association between substantial weight retention in the first postpartum year in our study, more research with high sample size and all BMI groups are needed. Moreover identifying the other risk factors for weight retention after birth to prevent obesity and its sequels on women to better decision making in prenatal care guidelines contents are required.
124: THE EFFECT OF EDUCATIONAL PACKAGE ON FUNCTIONAL STATUS OF PRIMIPAROUS WOMEN IN POSTPARTUM PERIOD: A RANDOMIZED CONTROLLED CLINICAL TRIAL
Authors: Shafaie Fahimeh Sehati , Mirghafourvand Mojgan , Bagherinia Marzieh 
Published: May 2024

Background and aims:Postpartum period is an important transition for parents, infants and families physiologically, emotionally and socially. The aim of this study was to determine the effect of training packages on functional status in the postpartum period.Method:This randomized controlled clinical trial was conducted on 136 primiparous women who were referred to health centers in Tabriz, Iran, for their second postpartum care (10–15 days after delivery). Primiparous women aged 18–35 with singleton pregnancy and term birth (37–42 weeks) were randomly assigned to training (n=68) and control (n=68) groups. The education group was provided with a face to face training session, three phone sessions, and a booklet. The control group received the routine postpartum care in days 1–3, 10–15, and 42–60. Participants completed the functional status questionnaire before the intervention and eight weeks postpartum. ANCOVA with adjustments for baseline score was used for analysis.Results:No statistically significant difference was found between the two groups in terms of socio-demographic characteristics except for infant's gender (p>0.05). At 6 weeks after the intervention and by adjusting for baseline scores, mean scores of functional status (Adjusted mean difference: 0.9; CI 95%: 0.8 to 1.03, p<0.001) in educational group were significantly higher than the control.Conclusion:Results showed that training women have a positive effect in improving their functional status.
133: THE EFFECT OF ZINGIBER OFFICINALE (GINGER) ON HYPERTENSION; A SYSTEMATIC REVIEW OF RANDOMISED CONTROLLED TRIALS
Authors: Torabi Mitra , Naeemzadeh Farnaz , Ebrahimi Vida , Taleschian-Tabrizi Negar , Pashazadeh Fariba , Nazemie Hossein 
Published: May 2024

Background and aims:Zingiber Officinale, commonly known as ginger, has been widely used traditionally in the daily diet and a variety of medicinal purposes. There are some animal studies on the hypotensive mechanism of ginger. The aim of this systematic review was to extract the evidence from all human participant randomized and quasi-randomized controlled trials that have assessed the effects of ginger on the blood pressure (BP) of any population.Methods:Databases including Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, CINAHL, ISI Web of Science and also local databases including Sid, magiran, iranmedex were searched up to June, 2016 without language limitation. Relevant bibliographies were also searched. Titles and abstracts were assessed independently by two reviewers and full papers of relevant articles were obtained and assessed. Randomized and quasi-randomized controlled trials on humans were enrolled in the review. Data extraction and risk of bias assessment were done by two reviewers independently and in a case of discrepancy final decision was made by the third reviewer. Meta-analysis was not possible because of heterogeneity of data and incomplete reporting of findings, thus results were synthesized narratively.Results:Initial searches yielded 60 articles. After analyzing full-text papers, 2 Randomized Controlled Trials (RCTs) met the inclusion criteria. A double blind RCT (n=70) compared the effect of ginger with placebo on cardiovascular risk factors in diabetic patients. There was no significant (p>0.05) effect on systolic nor diastolic pressure (Mean arterial blood pressure (MABP) changes was 0.1±1.1). A randomized three armed safety trial (n=60) studied the effects of 50 and 100mg/kg ginger and placebo in healthy subjects. 100 mg/kg dose significantly (p<0.05) lowered systolic BP from 114.3±3.22 mm Hg to 105.5±3.13 and diastolic BP from 73.3±3.35 mm Hg to 70.5±3.39 mm Hg within two hours.Conclusion:According to animal studies ginger has the potential to offer a natural alternative dietary supplementation to conventional anti-hypertensive agents, but still there is not enough evidence supporting this claim and current limited evidence is controversial. More human trials studying the effect of ginger on hypertensive patients using different dosage of a standardized extract are needed.
135: THE EFFECTS OF OBESITY AND VITAMIN D IN BODY RESPONSE TO HEPATITIS B VACCINE
Authors: Moludi Jalal , Alizadeh Mohammad 
Published: May 2024

Background and aims:Hepatitis B vaccination is the most successful way to prevent the virus infection. Serum concentration of vitamin D has recently been proposed as a novel predictor of response to antiviral treatment in chronic hepatitis infection. The main target of this paper was to review the recent knowledge regarding the association between obesity and vitamin D level and immune response to Hepatitis B vaccines.Methods:This review was written by referring to research literature including 32 articles published from 200 to 2015 on PubMed, Google Scholar, and Scopus databases. Searches were undertake on the key phrases of Hepatitis B, Obesity(overweight), Hepatitis B vaccine, antibody titre,Vitamin D level and other similar keywords. References included a variety of research papers (descriptive and analytical) and intervention articles.Results:In healthy patients, adequate hepatitis B surface antibody (HBsAb) titer is the most important for prevent hepatitis B. Secondly, obesity cased vitamin D insufficiency and immune system dysfunction. In patients with overweight, vitamin D deficiency is associated with a poor antibody formation upon hepatitis B vaccination, therefore hepatitis B vaccine maybe require booster doses at obese population should be considered.Conclusion:this review revealed an association between vitamin D deficiency and poor body response to vaccination in obese patients. The reduced immune response of overweight patients to immunization can be harmful not only for the patient but also for the community. In conclusion, vitamin D levels measured previously starting the vaccination should be considered.
145: THE PREVALENCE OF FATTY LIVER IN OVERWEIGHT AND OBESE CHILDREN COMPARED TO NORMAL CHILDREN
Authors: Zare Mostafa , Zhiani Asgharzade A , Mostafavi S , Abbasi F , Karimi M , Sobhani Shahmirzadi M , Zarei H , Gharib MH 
Published: May 2024

Background and aims:Nonalcoholic fatty liver disease is the most common cause of liver disease worldwide and is defined as a disorder of excess fat accumulation in the liver. This study aimed to determine the prevalence of fatty liver among overweight and obese children compared to normal children.Methods:This case-control study was conducted on 90 children ages 5 to 13. Children's Body Mass Index (BMI) was determined and the three groups obese (95% >BMI), over weight (85–95% BMI) and normal (5–85% BMI) divided. People in the study were matched for age and sex. Liver enzymes (ALT & AST) and lipid profile were measured and a radiologist who didn't know children's BMI examined them based on fatty liver sonographic parameters. And finally data analyzed using SPSS (Ver-18), ANOVA and Tukey's tests. Sometimes data distribution wasn't normal and Kruskal-Wallis test was used.Results:The prevalence of fatty liver was 23/3% in obese children that was higher compared with normal (16/7%) and over weight (16/7%) children. Based on the result of this study the prevalence of fatty liver wasn't significantly different between the sexes. AST was significantly higher in children with normal BMI (p<0.01) as well as cholesterol levels showed there was a significant difference among the three groups.Conclusion:Based on developing a large number of obese children in this age to fatty liver, these children should be using weight and waist circumference as an indicator of obesity and measuring LDL and ALT as risk factors of fatty liver disease and have regular screening.
147: THE ROLE OF MEDICAL LIBRARIANS IN PROMOTING EVIDENCE BASE MEDICINE IN IRAN
Authors: Motamedi Fatemeh , Khanjani Narges 
Published: May 2024

Background and aims:Evidence based medicine (EBM) is a systematic process that allows physicians and decision makers to access the most reliable and up to date information for the well-being of their patients and the society. The support of medical librarians is essential in this process. The present article reviews the role of medical librarians in EBM in Iran.Methods:In this review, information was gathered by searching different databases including PubMed, Science Direct, SID, Google Scholar and Scopus by these key words: (clinical librarian OR medical librarian OR medical informationist) AND (Evidence-Based Medicine OR Evidence-based practice) AND Iran. Retrieved articles were screened and the relevant articles were chosen.Results:Performing a comprehensive search and choosing the best relevant information is an important step in EBM. Librarians and medical informationists play an important role in finding, screening and appraising relevant medical literature and supporting clinicians in answering their medical questions. However, little research has been done in Iran and their role has not been well valued even in university hospitals in Iran.Conclusion:Librarians and medical informationists have an important role in improving medical decision making and encouraging the use of up to date literature. They can also help by cooperating in teaching efficient search skills and holding appropriate evidence based medicine journal clubs. Librarians should be used more efficiently to improve the quality of medical services and decrease the cost of medical treatment in Iran.
15: APPLICATION OF ACTION RESEARCH IN IMPROVING ADMINISTRATIVE AND FINANCIAL PROCESSES
Authors: Ahari Alireza Mahboob , Mousazadeh Yalda , Forootan Sara 
Published: May 2024

Background and aims:the administrative and financial activities are the most important affairs in any organization and include all affairs related to assets, staffs, formulating and implementing rules related to staff, supply of equipment and equipment for the organization. According to necessity of documentation and integration the different processes for each organizational unit, the aim of this study was identifying and promoting of administrative and financial processes of Management & Medical informatics faculty, Tabriz University of Medical Sciences.Methods:This study was a qualitative research with action research approach. Based on this approach after identifying the problem, planning is done for data collection. Planning includes recognizing the current condition of administrative and financial processes, identifying tasks and job description related to these processes and designing proper process by employee opinions about the process. Interviews were conducted in order to identify current conditions and proper form of process in implementation phase. Proper form of the process was found after negotiation with employee and was shown in the flowcharts. Checklist was used for assessing results.Results:There were no documented processes, before the study period. After the interviews, it became clear that employees apply too much personal opinions in all process. After the transcription and assessing interviews, according to job description and employee opinion, proper form of the processes were drawn. totally 44 process was identified and drawn that included 7 process related to public affairs office, 16 process related to staffing process, 2 process related to the secretariat, 12 accounting process and 7 process related to property office.Conclusion:In this study, the proper form of all process were identified and presented in the form of a booklet. Correct form and step by step process can avoid from arbitrary and sporadic in affairs, as well as duplication, waste of time and resources and customer dissatisfaction.
151: A LOOK AT THE EDUCATION AND PRACTICE OF EVIDENCE BASED LIBRARIANSHIP (EBL)
Authors: Gavgani Vahideh Zarea , Siamian Hasan 
Published: May 2024

Background and aims:The aim of this study was to find out the educational Model of Evidence Based Library and information Practice in the world. It will answer to the following questions: What are the reputed field names for EBL in other countries? In which levels (course or lesson) it is teaching, currently? Which universities are admitting for EBL? In which degrees EBL is supported? What is the prospect for Iranian Ministry of Health to establish this field of study?Methods:The study used citation and library method to find and describe the situation and quality of faculties offering the EBL as course or lesson. Reputed citation databases were searched for evidence and the Google search engine was employed to find and review the websites of universities which are delivering EBL.Results:The finding of this study shows that since the emergence of evidence based librarianship in the literature it has witnessed plenty names and currently is known as Evidence Based Library and Information Practice in the literature. It is offered by United States; Canadian and UK based universities in both the course and lesson level of education. It is almost offered in post graduate, post master and post-doctoral model. It has potential to be delivered as essential post master course for every discipline with research base.Conclusion:This study suggests a master of evidence based information management for Iran with Ministry of Health and Medical Education license. The best model for Iran would be interdisciplinary model of education by Medical Library and Information Science Department and Iranian Center of Evidence Based Medicine joint execution.