bluuebunny/crossref_metadata_2025_split huggingface dataset:
TANTANGAN IMPLEMENTASIAN PEMBELAJARAN KURIKULUM MERDEKA DI ERA SOCIETY 5.0 STUDY KASUS SMP MUHAMMADIYAH 3 MEDAN
Authors: Alliyah azzahra  , Siti Hanifah Hanum  , Siti Syevila  , Abdul Fattah Nasution  
Published: May 2024

Kurikulum ini bertujuan untuk mengembangkan generasi yang tidak hanya menghafal apa yang diajarkan guru, tetapi juga memanfaatkan teknologi dalam belajar. Kurikulum Merdeka memberi Anda kebebasan untuk menentukan topik pembelajaran sesuai minat dan kemampuan Anda, sehingga memungkinkan Anda mengembangkan proyek pembelajaran yang lebih kreatif. Metode penelitian yang digunakan peneliti dalam penelitian ini adalah pendekatan kualitatif dengan menggunakan metode deskriptif. Penelitian kualitatif lebih menekankan pada proses dan makna dengan menggunakan landasan teori untuk memandu fokus penelitian berdasarkan fakta lapangan. Kurikulum Merdeka tidak boleh sulit, namun harus memungkinkan pengembangan pembelajaran yang lebih baik. Perubahan kurikulum menjadi topik diskusi rutin untuk meningkatkan kualitas pendidikan di negara-negara berkembang.
Vasculitis de pequeños vasos: Análisis clínico, epidemiológico y terapéutico en 82 pacientes
Authors: Freire-Ochoa Jennifer Andrea , Pesántez Bravo María Carmen , Gómez Caballero María Eugenia , Merino Aguilera Patricio Alexander 
Published: May 2024

Objetivo: Determinar el perfil clínico, epidemiológico y terapéutico de los pacientes con diagnóstico de vasculitis de pequeños vasos.
Métodos: Se desarrollo un estudio descriptivo y retrospectivo en 82 pacientes con vasculitis de pequeños vasos atendidos en el departamento de Reumatología del Hospital Carlos Andrade Marín de la ciudad de Quito, durante el período enero 2019 a diciembre 2021 sobre las variables sociodemográficas, clínicas e inmunológicas, comorbilidades asociadas a la enfermedad, índice de actividad de la enfermedad al momento del diagnóstico y en el tratamiento.
Resultados: El 93,90% (n=77) de los pacientes viven en la zona urbana de en la provincia de Pichincha ciudad de Quito, identificándose como mestizos, con una prevalencia del 63,40% de mujeres. El tipo de vasculitis que más sobresale es la granulomatosis con poliangeitis con el 56,10% (n=46) de pacientes. El 69,50% tuvo como principal manifestación clínica las afectaciones renales y el 54,90% presentó alteración respiratoria. En relación con los marcadores inmunológicos, la presencia de ANCA C positivo representa el 46.3%. El medicamento más utilizado fueron los glucocorticoides al inicio de la enfermedad en un 98.8%. De los 86 pacientes en estudio, 25 fallecieron durante tres años de seguimiento.
Conclusiones: La granulomatosis con poliangeitis se presentó con mayor frecuencia, con una edad media al diagnóstico de 44 años en la población mestiza y la manifestación clínica más frecuente fue el compromiso renal.
الحوار الفكري ودوره في تعزيز السلم المجتمعي دراسة اجتماعية - تحليلية
Authors: أ.م. د. ريم أَيوب محمد أ.م. د. ريم أَيوب محمد , م. م هند زياد محمد م. م هند زياد محمد 
Published: May 2024

الملخص
إنّ الحوار الفكري هو وسيلة لغاية أسمى، وهي تحقيق التقارب بين الثقافات المختلفة، وتفادي الخلافات المؤدية للنزاعات والحروب والتطرف. فهو آلية أو وسيلة لتقريب وجهات النظر المتباعدة، وتحقيق التواصل والتفاهم بين الجماعات المتعايشة في مكان واحد أو في أمكنة مختلفة، لأن غياب الحوار الثقافي يؤدي إلى تفكيك وحدة المجتمع والنسيج الاجتماعي ، ويعود السبب في ذلك إلى أنّ لكل ثقافة نمط حياة وعادات وتقاليد تسهم في تكوين إطار خاص للثقافة، وانغلاقها على نفسها، مما يؤدي إلى تفكيك الإطار المشترك وهو المجتمع أو الدولة.
يكرس الحوار الفكري الاعتراف بشرعية جميع الثقافات الموجودة في المجتمع، وينمي روح السلم والتعايش المجتمعي بين مختلف الفئات والاقليات ، ويعمل على التعرف على عادات الثقافات الأُخر وقيمها وتقاليدها وتحقيق المساواة والحريات بين جميع الثقافات الموجودة داخل المجتمع، والاحترام المتبادل بين الثقافات المختلفة .

©THISISANOPENACCESSARTICLEUNDERTHECCBY LICENSE.http://creativecommons.org/licenses/by/4.0/

ولا يمكن تصور حوار ثقافي حقيقي إذا لم يكن هناك إقرار بمبدأ التنوع الثقافي ، فالتنوع الثقافي عامل أساسي للفهم المتبادل والتعايش السلمي والسير نحو التقدم الاقتصادي والاجتماعي، وحماية التراث لجميع الشعوب التي يتعرض تراثها الفكري والثقافي والحضاري لمحاولات التشويه والتزوير والطمس والتدمير.
ومن جهة أخرى، فإن التنوع الثقافي، الذي هو حق من حقوق الشعوب، وفطرة في الإنسان وطبيعة في الحياة وسنة في الكون، يقتضي التقارب بين الثقافات، بحكم أنّ التنوع هو مدعاة للتقارب، بخلاف الانغلاق الذي هو سبيل إلى الانكماش المفضي إلى ضمور الثقافات وسقوط الحضارات ([1]).

[1] د. سمير الشرقاوي السموني ،الحوار الثقافي واثره على التماسك الاجتماعي ، موقع الجزيرة ،https://www.al-jazirah.com/ 24ابريل 2020 تاريخ الزيارة 28/4/2023 .
Corporate Governance, Agency Costs, and Financial Performance: A Systematic Literature Review
Authors: Otto Thomas 
Published: May 2024

Good corporate governance practices are critical for both private and public sector organizations to enhance their financial performance. Despite the various theories and models produced to explain the correlation between these two factors, the link continues to be a mystery. It has not yet been established how corporate governance influences financial performance and whether there are underlying variables that can moderate or intervene the association between corporate governance and financial performance. The intention of this paper was to perform a critical theoretical and empirical literature review. The specific objectives were to conduct literature review on; the association between corporate governance and financial performance; and the effect of agency costs on the correlation between corporate governance and financial performance. The review is of significance to the management of firms, policy-making entities and to the literature of finance. The management of firms may use the conclusions and study recommendations to formulate effective corporate governance structures which will enhance financial performance of their firms. The study will also be of value to policymaking organizations like regulators that formulate the various polices on corporate governance. The research anchor theory is agency theory as it explains in what manner management, being agent, is supposed to fulfill their perfect fiduciary duty of serving the principal’s best interests to enhance the main goal of a firm. The theory holds that strong corporate governance structures provide better monitoring leading to managerial efficiency. Other theories guiding this study included stakeholder theory, the institutional theory and resource dependence theory. The theoretically expected relationship between study variables is inconclusive as corporate governance is expected to provide better monitoring leading to a positive influence on financial performance but it also comes with agency costs which might lower the financial performance. From the empirical studies reviewed, most studies conclude that corporate governance influence financial performance in a positive way but it is also evident that the studies also provide conflicting findings with some oscillating from negative to positive and others indicating no relationship at all. The study also found that the primary limitations in this field of research include an absence of related studies in frontier economies and contradictions in research findings.
Socio-economic Variables Influencing the use of Information and Communication Technologies (ICTS) in Agricultural Extension Service Delivery Among Farmers in Yobe State, Nigeria
Authors: Mohammed, N  
Published: May 2024

The study assessed socio-economic variables influencing the use of information and communication technologies (ICTs) in agricultural extension service delivery among farmers in Yobe state, Nigeria. The specific objectives of the study were to: describe the socio-economic characteristics of the farmers in the study area; examine the use of ICTs among the farmers in the study area; and determine the relationship between selected socio-economic characteristics of the farmers and the use of ICTs in the study area. A multi-stage sampling procedure was employed. Data were obtained primarily from 130 respondents through structured questionnaire. Data collected were analyzed using frequency counts, percentages, mean, and multiple regressions. The results on socio-economic characteristics revealed that majority (67.7%) of the respondents were male, married and within the active age group of 26-40 years (54.6%). Majority (49.2%) had no formal education with a mean household size of 5.35 indicating over dependency on family labor. The respondents (34.6%) had 11-20 years of farming experience but lack ICT proficiency training and were not members of any cooperatives while (57.7%) cultivates between 2-4 hectares in which (47.7%) earns between ₦100, 001-₦300, 000 per annum. Mobile phone, internet and radio were the most frequently used ICT tools by farmers in the study area. The results of multiple regression analysis revealed a high coefficient of multiple determinations (R2) of 0.711. This indicates that 71.1% of the total variables were caused by changes in the independent variables. Educational level, farming experience, computer literacy, and annual income are statistically significant at p≤0.01 level of significance. The study concludes that farmers utilize a limited number of ICTs, although these tools are moderately available and accessible. The study recommended that awareness on the use of ICTs such as the internet and computer for agricultural information transfer and retrieval should be encouraged, dissemination of agricultural information through radio and television programs as well as mobile phone would be recommended for greater agricultural production.
Impact of Surgical Margin on Prognosis and Recurrence in Intrahepatic Cholangiocarcinoma
Authors: Doi Shunsuke , Yasuda Satoshi , Hokuto Daisuke , Kamitani Naoki , Matsuo Yasuko , Sakata Takeshi , Nishiwada Satoshi , Nagai Minako , Terai Taichi , Kohara Yuichiro , Sho Masayuki 
Published: May 2024

Objective
This study investigated the impact of surgical margin (SM) on the prognosis and recurrence of intrahepatic cholangiocarcinoma (ICC).

Summary of background data
The impact of SM on the prognosis remains controversial.

Methods
We analyzed 58 ICC patients who underwent macroscopically curative surgery. The patients were classified into 5 categories according to the SM; microscopically positive (R1), 0 to &lt;1 mm, 1 to &lt;5 mm, 5 to &lt;10 mm, and ≥10 mm. The overall survival (OS) rate was significantly different for SM &lt;1 mm or SM ≥1 mm; therefore, the cutoff value was set at 1 mm.

Results
Twenty-five patients (43.1%) had an SM &lt;1 mm, and 33 (56.9%) had an SM ≥1 mm. The multivariate analysis identified SM &lt;1 mm (P = 0.027) as an independent predictor of OS. After the propensity score matching based on tumor-related factors, the OS rate of the SM &lt;1 mm group was significantly lower than that of the SM ≥1 mm group (P = 0.013). Peritoneal dissemination was significantly increased in the SM &lt;1 mm group (P = 0.007). The postrecurrence survival rate of the SM &lt;1 mm group was significantly lower than that of the SM ≥1 mm group (P = 0.012).

Conclusions
This study suggests that an SM of at least 1 mm should be achieved regardless of tumor status during ICC resection. An SM &lt; 1 mm may indicate a higher risk of peritoneal dissemination.
Networks with large solvent recycle: Dynamics, hierarchical control, and a biorefinery application
Authors: Jogwar Sujit S. , Torres Ana I. , Daoutidis Prodromos 
Published: June 2011

AbstractA class of networks featuring large recycle of solvent is analyzed. This feature is central to numerous integrated processes which use solvents in various reaction and separation steps. A prototype network capturing the essential features of such networks is identified. Rigorous dynamic analysis reveals the presence of two time‐scale dynamics exhibited by this prototype network. A systematic framework for model reduction and a subsequent hierarchical control design is proposed. The advantages of the proposed design over direct model‐based control are demonstrated via a simulation case study. Finally, the application of the proposed framework to a newly proposed process for the production of 5‐hydroxymethylfurfural from fructose is also presented. © 2011 American Institute of Chemical Engineers AIChE J, 58: 1764–1777, 2012
Model selection and parameters estimation in kinetic thermal evaluations using semiempirical models
Authors: Sanchirico Roberto 
Published: June 2011

AbstractThe minimum number of thermoanalytical experiments that should be considered with the aim of performing a complete and reliable kinetic analysis when using semiempirical models is the problem of concern. It is shown by means of a series of numerical experiments that three differential scanning calorimetric (DSC) dynamic runs performed at different heating rates provide a complete and reliable kinetic analysis while the topological structure of two DSC curves is enough to determine the semiempirical model (among reaction order and Sestack–Bergrenn) that better describe the experimental data. The procedure is analyzed by means of the simulation of a complex kinetic scheme and the results verified considering the thermal decomposition of cumene hydroperoxide. The proposed approach can be easily generalized to different kinetic models and is provided with a possible criterion devoted to identify autocatalytic processes by means of dynamical DSC experiments. © 2011 American Institute of Chemical Engineers AIChE J, 58: 1869–1879, 2012
Laboratory evaluation of clopidogrel responsiveness by platelet function and genetic methods
Authors: Smock Kristi J. , Saunders Peter J. , Rodgers George M. , Johari Vandita 
Published: June 2011

AbstractClopidogrel is a widely used antiplatelet agent that irreversibly inhibits platelet P2Y12 ADP receptors after conversion to an active metabolite. There are a number of laboratory tests capable of detecting clopidogrel‐induced platelet inhibition and published literature correlates suboptimal clopidogrel response to adverse cardiovascular outcomes. Genetic polymorphisms are thought to affect conversion of the prodrug to the active metabolite, and the FDA has recently added a black‐box warning to clopidogrel to highlight the effects of these polymorphisms on drug bioavailability and to inform prescribers about the availability of genetic testing. For these reasons, there is growing interest in the use of laboratory tests to monitor patients treated with clopidogrel. This article summarizes the currently available laboratory testing, including platelet function tests and genotyping for CYP2C19 variants. Am. J. Hematol., 2011. © 2011 Wiley‐Liss, Inc.
Vitamin A dynamics in breastmilk and liver stores: A life history perspective
Authors: Fujita Masako , Shell‐Duncan Bettina , Ndemwa Philip , Brindle Eleanor , Lo Yun‐Jia , Kombe Yeri , O'connor Kathleen 
Published: June 2011

AbstractObjectives:Newborns are dependent on breastmilk vitamin A for building hepatic stores of vitamin A that will become critical for survival after weaning. It has been documented that vitamin A concentrations in breastmilk decline across the first year postpartum in both well‐nourished and malnourished populations. The reason for this decline has been assumed to be a sign of concurrently depleting maternal hepatic stores. This study investigates this assumption to clarify why the decline occurs, drawing on life history theory.Methods:A cross sectional survey was conducted among lactating mothers in Kenya in 2006. Data were used to examine (1) the relationship between liver vitamin A and time, (2) if the relationship between milk and liver vitamin A varies by time, and (3) by maternal parity.Results:The relationship between liver vitamin A and time fits the quadratic pattern with marginal significance (P= 0.071,n= 192); the liver vitamin A declined during early postpartum then recovered in late postpartum time, controlling covariates. The milk‐liver vitamin A relationship varied by postpartum time periods (P= 0.03) and by maternal parity (P= 0.005). Mothers in earlier postpartum or higher parity had a stronger positive relationship between milk and liver vitamin A than mothers in later postpartum or lower parity.Conclusions:Our observations are consistent with life history tradeoffs and negate the assumption that maternal hepatic and milk vitamin A decline together. Rather, maternal liver vitamin A has a dynamic relationship with milk vitamin A, particularly depending on postpartum time and maternal parity. Am. J. Hum. Biol., 2011. © 2011 Wiley‐Liss, Inc.
Within‐group social bonds in white‐faced saki monkeys (Pithecia pithecia) display male–female pair preference
Authors: Thompson Cynthia L. , Norconk Marilyn A. 
Published: June 2011

AbstractWhite‐faced saki monkeys (Pithecia pithecia) lack most of the behavioral and physical traits typical of primate monogamy [Fuentes,1999]. In order to determine if social bonds in this species reflect patterns displayed by pair‐bonded groups or larger multimale–multifemale groups, we draw on 17 months of data collected on wild white‐faced sakis at Brownsberg Nature Park, Suriname. We analyzed within‐group social bonds for three habituated groups (one two‐adult and two multiadult groups) by measuring grooming, proximity, and approach/leave patterns between adult and subadult group members. We found that both two‐adult and multiadult groups showed significantly stronger social bonds between a single male–female dyad within each group (deemed “primary dyads”). In all three groups, primary dyads were composed of the oldest adult male and a breeding female. These pairs had significantly higher levels of grooming than other within‐group dyads and were also in close proximity (<1 m) more often than nonprimary dyads. Grooming in primary dyads was nonreciprocal, and consistently biased toward female investment. Grooming patterns in nonprimary dyads varied, but were often more reciprocal. Grooming and proximity of the primary dyad also changed in relation to infant development. Our results suggest that while white‐faced sakis do not show behavioral and physical traits typical of monogamy or pair‐bonding, social bonds are strongest between a single male–female pair. Pitheciine social systems range from small group monogamy inCallicebusto large multimale–multifemale groups inChiropotesandCacajao. As the middle taxon in this platyrrhine radiation, behavioral strategies of white‐faced sakis provide a model for how social bonds and affiliation could be influenced by and affect the evolution of larger group size in primates. Am. J. Primatol. 73:1051–1061, 2011. © 2011 Wiley‐Liss, Inc.
Synthesis of Some Triazolophthalazine Derivatives for Their Anti‐Inflammatory and Antimicrobial Activities
Authors: Habib Nargues S. , Farghaly Ahmed M. , Ashour Fawzia A. , Bekhit Adnan A. , Abd El Razik Heba A. , Abd El Azeim Tarek 
Published: June 2011

AbstractSeveral novel series of triazolophthalazine derivatives namely; pyrazolylethenyltriazolophthalazinones (4a–d), styryltriazolophthalazinones (5a,b), aryloxopropenyltriazolophthalazinones (7a,b), pyrazolinyl‐ (8a,b), (9a,b) and (10a–f), pyrazolyl‐ (11a–d), (1,2‐oxazol‐5‐yl)‐1,2,4‐triazolo[3,4‐a]phthalazin‐6(5H)‐ones (14a,b), triazolo[3,4‐a]phthalazin‐3‐yl‐pyridine‐3‐carbonitriles (12a,b), triazolo[3,4‐a]phthalazin‐3‐yl)ethylthioacetic acids (13a,b) and 2‐aryl‐5‐arylamino‐1H,5H‐pyrazolo[2″,3″‐1′,5′]imidazo[3′,4′‐1,5]‐1,2,4‐triazolo[3,4‐a]phthalazin‐12(13H)‐ones (15a–c) have been synthesized. The anti‐inflammatory activity of representative compounds has been studied. Compounds 8b, 10c, 10f, 11b, 12a, 13b, and 15a showed anti‐inflammatory activities comparable to that of the reference standard, indomethacin. They exhibit also minimal ulcerogenic effect relevant to the reference standard and were found to be non‐toxic up to 120 mg/kg orally or up to 75 mg/kg through parenteral route. Concerning the antimicrobial activity; compounds 12b and 13b were found to be equipotent to ampicillin against Staphylococcus aureus, while compounds 10a and 10f were found to be as potent as ampicillin against E. coli, whereas compound 14b exhibited equipotency to clotrimazole against Candida albicans. Compounds 8b, 10f, 11b, 12a, and 13b exhibited, besides their antimicrobial activity, moderate to potent anti‐inflammatory profiles. This represents a fruitful matrix for the development of a new class of dual non‐acidic anti‐inflammatory/antimicrobial agents.
Cytotoxic and Antimicrobial Activities of Cu(II), Co(II), Pt(II) and Zn(II) Complexes with N,O‐Chelating Heterocyclic Carboxylates
Authors: Buczkowska Magdalena , Bodtke Anja , Lindequist Ulrike , Gdaniec Maria , Bednarski Patrick J. 
Published: June 2011

AbstractA series of Cu(II), Co(II), Pt(II) and Zn(II) coordination compounds has been prepared by the reaction of the metal chlorides with pyrazine‐2‐carboxylic acid, pyridine‐2‐carboxylic acid, imidazole‐4‐carboxylic acid, benzimidazole‐2‐carboxylic acid and 1‐methylimidazole‐2‐carboxylic acid. The complexes were characterized by IR, UV‐VIS, elemental analysis, and some by 1H‐NMR, X‐ray crystallography, HPLC and LC/MS spectroscopy. All complexes consist of a 2:1 ratio of ligand to metal ion. IR and X‐ray crystallography show that coordination is through the nitrogen and carboxylate oxygen donor atoms of the ligand to form chelating rings. DFT calculations predict that the trans‐coordinated isomers are thermodynamically more stable than their cis‐forms. Only one of five complexes studied by X‐ray crystallography, Cu(II) complex of 1‐methylimidazole‐2‐carboxylic acid showed a cis‐configured metal ion center. HPLC analysis indicated that Pt(II) complex of 1‐methylimidazole‐2‐carboxylic acid is dominated (>90%) by the trans‐configured complex. All other complexes showed one isomer, presumably the trans‐form. The cytotoxic activity was investigated in human cancer cell lines in vitro; only the Pt(II) complexes were active. The antimicrobial activity against four bacterial strains and one fungi was estimated by the MIC method and best results were found amongst the Co(II) complexes. These results indicate that trans‐coordinated bischelating N,O‐heterocyclic carboxylates of Pt(II) are an interesting new class of potential antitumor agents.
Dynamic mRNA and miRNA profiling of CHO‐K1 suspension cell cultures
Authors: Bort Juan A. Hernández , Hackl Matthias , Höflmayer Helga , Jadhav Vaibhav , Harreither Eva , Kumar Niraj , Ernst Wolfgang , Grillari Johannes , Borth Nicole 
Published: June 2011

AbstractIn spite of the importance of Chinese hamster ovary (CHO) cells for recombinant protein production, very little is known about the molecular and gene regulatory mechanisms that control cellular phenotypes such as enhanced growth under serum‐free conditions or high productivity. Most microarray analyses to this purpose are performed with samples taken during the exponential growth phase. However, the cellular transcriptome is dynamic, changing in response to external and internal stimuli and thus reflecting the current functional capacity of cells as well as their ability to adapt to a changing environment. Therefore, during batch or fed‐batch cultivations it can be expected that the transcription pattern of genes will change and that such changes may give indications on the cellular state in terms of viability, growth, and productivity. In the current study we monitored the change in expression patterns of mRNAs and microRNAs (miRNA) during lag, exponential, and stationary phases in CHO‐K1 suspension cell cultures. In total, over 1400 mRNAs and more than 100 miRNAs were differentially regulated (p<0.05) relative to the batch culture at the starting point. Functional clustering revealed groups of genes with similar expression patterns, which were subjected to functional pathway analysis. In addition, as miRNAs generally act as negative post‐transcriptional regulators of mRNAs, we looked for changes in their expression that were inverse to those of their predicted target mRNAs.