bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age at onset and clinical features of late life compulsive hoarding
Authors: Ayers Catherine R. , Saxena Sanjaya , Golshan Shahrokh , Wetherell Julie Loebach 
Published: June 2009

AbstractObjectivesCompulsive hoarding is a debilitating, chronic disorder, yet we know little about its onset, clinical features, or course throughout the life span. Hoarding symptoms often come to clinical attention when patients are in late life, and case reports of elderly hoarders abound. Yet no prior study has examined whether elderly compulsive hoarders have early or late onset of hoarding symptoms, whether their hoarding symptoms are idiopathic or secondary to other conditions, or whether their symptoms are similar to compulsive hoarding symptoms seen in younger and middle‐aged populations. The objectives of this study were to determine the onset and illustrate the course and clinical features of late life compulsive hoarding, including psychiatric and medical comorbitities.MethodsParticipants were 18 older adults (≥60) with clinically significant compulsive hoarding. They were assessed using structured interviews, including the Mini International Neuropsychiatric Interview (MINI), Structured Clinical Interview for DSM‐IV (SCID I), Yale–Brown Obsessive Compulsive Scale (YBOCS), and UCLA Hoarding Severity Scale (UHSS). Self‐report Measures Included the Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), Sheehan Disability Scale (SDS), and Savings Inventory‐Revised (SI‐R). Psychosocial and medical histories were also obtained. To determine age at onset, participants were asked to rate their hoarding symptoms and describe major life events that occurred during each decade of their lives.ResultsResults show that (1) onset of compulsive hoarding symptoms was initially reported as being in mid‐life but actually found to be in childhood or adolescence. No subjects reported late onset compulsive hoarding. (2) Compulsive hoarding severity increased with each decade of life. (3) Comorbid mood and anxiety disorders were common, but only 16% of patients met criteria for OCD if hoarding symptoms were not counted toward the diagnosis. (4) The vast majority of patients had never received treatment for hoarding. (5) Older adults with compulsive hoarding were usually socially impaired and living alone.ConclusionsCompulsive hoarding is a progressive and chronic condition that begins early in life. Left untreated, its severity increases with age. Compulsive hoarding should be considered a distinct clinical syndrome, separate from OCD. Unfortunately, compulsive hoarding is largely unrecognized and untreated in older adults. Copyright © 2009 John Wiley & Sons, Ltd.
Relative resistance of SGK1 knockout mice against chemical carcinogenesis
Authors: Nasir Omaima , Wang Kan , Föller Michael , Gu Shuchen , Bhandaru Madhuri , Ackermann Teresa F. , Boini Krishna M. , Mack Andreas , Klingel Karin , Amato Rosario , Perrotti Nicola , Kuhl Dietmar , Behrens Jürgen , Stournaras Christos , Lang Florian 
Published: June 2009

AbstractThe serum and glucocorticoid inducible kinase SGK1 was originally cloned from mammary tumor cells. SGK1 was found to be up‐regulated in a variety of tumors, but down‐regulated in several distinct tumors. Thus, evidence for a role of SGK1 in tumor growth remained conflicting. According toin vitroobservations, SGK1 is up‐regulated by the oncogene β‐catenin and negatively regulates the proapoptotic transcription factor FOXO3a, which in turn stimulates transcription of the Bcl2‐interacting mediator BIM. This study aimed to define the role of SGK1 in colon carcinomain vivo. SGK1 knockout mice (sgk1−/−) and their wild type littermates (sgk1+/+) were subjected to chemical cancerogenesis (intraperitoneal injection of 20 mg/kg 1,2‐dimethylhydrazine followed by three cycles of 30 g/L synthetic dextran sulfate sodium for 7 days). Moreover, SGK1 was silenced in HEK293 cells. FOXO3a and BIM protein abundance was determined by Western blotting and immunohistochemistry. Following chemical cancerogenesis,sgk1−/−mice developed significantly less colonic tumors thansgk1+/+mice. According to Western blotting and immunohistochemistry, SGK1 deficiency enhanced the expression of FOXO3a and BIM both,in vitroandin vivo. SGK1 deficiency counteracts the development of colonic tumors, an effect at least in part due to up‐regulation of FOXO3a and BIM. © 2009 IUBMB IUBMB Life, 61(7): 768–776, 2009
How does changing age distribution impact stock prices? A nonparametric approach
Authors: Park Cheolbeom 
Published: June 2009

AbstractThis paper examines whether variations in demographic structure have influenced stock prices. The study employs a nonparametric approach based on the Fourier Flexible Form representation, which relates variations in the entire age distribution to the normalized stock price under a flexible functional form. The main findings of this paper are that there is a significant impact from prime working‐age consumers on the stock price, and that this impact is robust for all G5 countries (France, Germany, Japan, the UK and the USA). These findings survive many robust tests, and are consistent with the predictions from the life‐cycle models. Copyright © 2009 John Wiley & Sons, Ltd.
Reduced L‐arginine transport contributes to the pathogenesis of myocardial ischemia‐reperfusion injury
Authors: Venardos Kylie M. , Zatta Amanda J. , Marshall Tanneale , Ritchie Rebecca , Kaye David M. 
Published: June 2009

AbstractMyocardial injury due to ischemia‐reperfusion (I‐R) damage remains a major clinical challenge. Its pathogenesis is complex including endothelial dysfunction and heightened oxidative stress although the key driving mechanism remains uncertain. In this study we tested the hypothesis that the I‐R process induces a state of insufficient L‐arginine availability for NO biosynthesis, and that this is pivotal in the development of myocardial I‐R damage. In neonatal rat ventricular cardiomyocytes (NVCM), hypoxia‐reoxygenation significantly decreased L‐arginine uptake and NO production (42 ± 2% and 71 ± 4%, respectively, both P < 0.01), maximal after 2 h reoxygenation. In parallel, mitochondrial membrane potential significantly decreased and ROS production increased (both P < 0.01). NVCMs infected with adenovirus expressing the L‐arginine transporter, CAT1, and NVCMs supplemented with L‐arginine both exhibited significant (all P < 0.05) improvements in NO generation and mitochondrial membrane potentials, with a concomitant significant fall in ROS production and lactate dehydrogenase release during hypoxia‐reoxygenation. In contrast, L‐arginine deprived NVCM had significantly worsened responses to hypoxia‐reoxygenation. In isolated perfused mouse hearts, L‐arginine infusion during reperfusion significantly improved left ventricular function after I‐R. These improved contractile responses were not dependent on coronary flow but were associated with a significant decrease in nitrotyrosine formation and increases in phosphorylation of both Akt and troponin I. Collectively, these data strongly implicate reduced L‐arginine availability as a key factor in the pathogenesis of I‐R injury. Increasing L‐arginine availability via increased CAT1 expression or by supplementation improves myocardial responses to I‐R. Restoration of L‐arginine availability may therefore be a valuable strategy to ameliorate I‐R injury. J. Cell. Biochem. 108: 156–168, 2009. © 2009 Wiley‐Liss, Inc.
Enhanced fracture repair by leukotriene antagonism is characterized by increased chondrocyte proliferation and early bone formation: A novel role of the cysteinyl LT‐1 receptor
Authors: Wixted John J. , Fanning Paul J. , Gaur Tripti , O'Connell Shannon L. , Silva Jason , Mason‐Savas April , Ayers David C. , Stein Gary S. , Lian Jane B. 
Published: June 2009

AbstractInflammatory mediators and drugs which affect inflammation can influence the healing of injured tissues. Leukotrienes are potent inflammatory mediators, and similar to prostaglandins, are metabolites of arachidonic acid which can have positive or negative effects on bone and cartilage tissues. Here we tested the hypothesis that blocking the negative regulation of leukotrienes, would lead to enhanced endochondral bone formation during fracture repair. A closed femoral fracture was created in mice. Animals were divided into three groups for treatment with either montelukast sodium, a cysteinyl leukotriene type 1 receptor antagonist (trade name Singulair), zileuton, a 5‐lipoxygenase enzyme inhibitor (trade name Zyflo), or carrier alone. The fractures were analyzed using radiographs, quantitative gene expression, histology and histomorphometry, and immunohistochemistry. Both the montelukast sodium group and the zileuton group exhibited enhanced fracture repair when compared with controls. Both treatment groups exhibited increased callous size and earlier bone formation when compared to controls as early as day 7. Gene expression analysis of treatment groups showed increased markers of chondrocyte proliferation and differentiation, and increased early bone formation markers when compared with controls. Treatment with montelukast sodium directly targeted the cysteinyl leukotriene type 1 receptor, leading to increased chondrocyte proliferation at early time points. These novel findings suggests a potential mechanism by which the cysteinyl leukotriene type 1 receptor acts as a negative regulator of chondrocyte proliferation, with important and previously unrecognized implications for both fracture repair, and in a broader context, systemic chondrocyte growth and differentiation. J. Cell. Physiol. 221: 31–39, 2009. © 2009 Wiley‐Liss, Inc.
Acute ammonia toxicity and the protective effects of methionine sulfoximine on the swamp eel, Monopterus albus
Authors: Tng Yvonne Y. M. , Chew Shit F. , Wee Nicklaus L. J. , Wong Fung K. , Wong Wai P. , Tok Chia Y. , Ip Yuen K. 
Published: June 2009

AbstractThe objectives of this study were to examine how the swamp eel, Monopterus albus, defended against acute ammonia toxicity derived from the intraperitoneal injection with a sublethal dose (10 µmol g−1 fish) of ammonium acetate (CH3COONH4) followed by 24 hr of emersion, and to elucidate the mechanisms of acute ammonia toxicity with respect to glutamine accumulation in the brain using L‐methionine S‐sulfoximine [MSO; a glutamine synthetase inhibitor]. When confronted with a sublethal dose of CH3COONH4 followed by emersion, only a small fraction of the exogenous ammonia was excreted, and ammonia contents in various organs, especially the brain, increased transiently to high levels. Increased glutamine synthesis and decreased amino acid catabolism in and outside the brain were involved in the defence against acute ammonia toxicity. When injected with a lethal dose (16 µmol g−1 fish) of CH3COONH4 followed by emersion, ammonia (∼30 µmol g−1 tissue), but not glutamine (∼5 µmol g−1 tissue), accumulated to extraordinarily high levels in the brain of succumbed fish. Hence, glutamine accumulation in the brain might not be the major mechanism of acute ammonia toxicity in M. albus. MSO (100 µg g−1 fish) had a partial protective effect in fish injected with a lethal dose of CH3COONH4. However, this effect was unrelated to the suppression of glutamine synthesis and accumulation in the brain. Instead, MSO suppressed the rate of ammonia buildup in the brain, possibly through its effects on glutamate dehydrogenase therein. J. Exp. Zool. 311A: 676–688 2009. © 2009 Wiley‐Liss, Inc.
Introduction to a Special Issue of theJournal of Investigative Psychology and Offender Profiling
Authors: Youngs Donna 
Published: June 2009

AbstractWhen offender profiles have been presented as evidence in court, although in a few cases they may have been accepted initially, they have invariably been excluded on appeal. But with the evolution of Investigative Psychology as a systematic science with a broader remit than producing ‘offender profiles’, a framework for contributions to investigations has emerged over the last 20 years that maps out the rich potential range of contribution to the legal process. This considers not only the drawing of inferences about offenders from their actions (profiling), but also examination of testimony and what psychological processes may indicate whether it has been distorted deliberately or accidentally. Further, the decision‐making processes, especially as part of the investigation that gave rise to evidence presented are also subject to behavioural scrutiny. This special issue of The Journal of Investigative Psychology and Offender Profiling provides examples of these contributions as a basis for encouraging debate about links between Investigative Psychology and the courtroom. Copyright © 2009 John Wiley & Sons, Ltd.
Evaluation of adipose‐derived stromal vascular fraction or bone marrow‐derived mesenchymal stem cells for treatment of osteoarthritis
Authors: Frisbie David D. , Kisiday John D. , Kawcak Chris E. , Werpy Natasha M. , McIlwraith C. Wayne 
Published: June 2009

AbstractThe purpose of this study was the assessment of clinical, biochemical, and histologic effects of intraarticular administered adipose‐derived stromal vascular fraction or bone marrow‐derived mesenchymal stem cells for treatment of osteoarthritis. Osteoarthritis was induced arthroscopically in the middle carpal joint of all horses, the contralateral joint being sham‐operated. All horses received treatment on Day 14. Eight horses received placebo treatment and eight horses received adipose‐derived stromal vascular fraction in their osteoarthritis‐affected joint. The final eight horses were treated the in osteoarthritis‐affected joint with bone marrow‐derived mesenchymal stem cells. Evaluations included clinical, radiographic, synovial fluid analysis, gross, histologic, histochemical, and biochemical evaluations. No adverse treatment‐related events were observed. The model induced a significant change in all but two parameters, no significant treatment effects were demonstrated, with the exception of improvement in synovial fluid effusion PGE2 levels with bone marrow‐derived mesenchymal stem cells when compared to placebo. A greater improvement was seen with bone marrow‐derived mesenchymal stem cells when compared to adipose‐derived stromal vascular fraction and placebo treatment. Overall, the findings of this study were not significant enough to recommend the use of stem cells for the treatment of osteoarthritis represented in this model. © 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27:1675–1680, 2009
The US semiconductor industry in the 1990s: strategies and outcomes
Authors: Kaymak Turhan 
Published: June 2009

Abstract

The semiconductor industry was one of the chief beneficiaries and drivers of globalization in the 1990s. The competitive environment of that decade provided opportunities for multinational enterprises (MNEs) and domestic firms operating in the US marketplace.

The purpose of this paper is to identify whether there are relationships between certain business‐level strategies and firm‐level performance in the US semiconductor sector. Also, we investigate whether MNEs outperform their domestic‐oriented rivals.

Using objective measures, we uncover that a low‐cost strategy is associated with performance, while focus and differentiation strategies have negative relationships with performance. Also, firm size is strongly related to performance.

Our study contributes to our understanding of business‐level strategies with its development of new objective measures, while our findings question whether being a MNE is necessarily an advantage in the semiconductor industry.

Copyright © 2009 John Wiley & Sons, Ltd.
Phenols in spikelets and leaves of field‐grown oats (Avena sativa) with different inherent resistance to crown rust (Puccinia coronata f. sp. avenae)
Authors: Dimberg Lena H , Peterson David M 
Published: June 2009

AbstractBACKGROUND: Avenanthramides, health‐beneficial phenols in oats, are produced in response to incompatible races of the crown rust fungus, Puccinia coronata, in seedlings of greenhouse‐grown oats. This study aimed to elucidate whether avenanthramides and/or other phenolic compounds, together with the activities of phenylalanine ammonia lyase (PAL), phenoloxidase (PO) and the avenanthramide biosynthetic enzyme hydroxycinnamoyl‐CoA:hydroxyanthranilate‐N‐hydroxycinnamoyl transferase (HHT), are associated with crown rust infection in mature field‐grown oats. Nine oat (Avena sativa L.) genotypes with wide variation in crown rust resistance were exposed to naturally occurring fungal spores during the growth period.RESULTS: In the spikelets avenanthramides as well as HHT activities were more abundant in the crown rust resistant genotypes, whereas p‐coumaric and caffeic acids were more abundant in the susceptible ones. In the leaves avenanthramides were not associated with resistance. Instead two unknown compounds correlated negatively with the rust score. Phenols released by alkaline hydrolysis and PAL and PO activities were not related to rust infection, either in spikelets or in the leaves.CONCLUSION: Because grains of crown rust‐resistant oat genotypes seemed to have higher endogenous levels of health‐promoting avenanthramides, use of resistant oats may contribute to a food raw material with health‐beneficial effects. Copyright © 2009 Society of Chemical Industry
Characteristics and prognosis for molecular breast cancer subtypes in Chinese women
Authors: Zhao Jing , Liu Hong , Wang Meng , Gu Lin , Guo Xiaojing , Gu Feng , Fu Li 
Published: June 2009

AbstractBackgroundBreast cancer is regarded as a heterogeneous disease with four molecular subtypes. However, the clinicopathological characteristics among the different subtypes have not been studied in Chinese demographic. This study clarifies the prevalence and clinicopathological features of each subtype and investigates the independent prognosis factors in the Chinese population.MethodsA retrospective review of 1,820 Chinese breast cancer women were classified into different molecular subtypes based on the IHC‐based definitions for ER, PR, and HER‐2/neu to evaluate the clinicopathological features and prognosis.ResultsLuminal A subtype was the most prevalent with the oldest median age at first full‐term birth. The basal cell‐like subtype was associated with early onset, higher percentage of node positivity, family history of breast cancer, increased tumor size, advanced tumor grade, higher prevalence in the premenopausal group, and the earlier age at menarche. Univariate and multivariate analysis of OS and RFS identified the basal cell‐like and HER‐2/neu subtypes as negative prognostic factors. A family history was an independent predictor of shorter RFS and OS in only the basal cell‐like subtype.ConclusionsThe basal cell‐like subtype is associated with a poor prognosis and a family history was a negative predictor in the basal cell‐like subtype. J. Surg. Oncol. 2009;100:89–94. © 2009 Wiley‐Liss, Inc.
Impact of the number of resected and involved lymph nodes on esophageal cancer survival
Authors: Chen Yi‐Jen , Schultheiss Timothy E. , Wong Jeffrey Y.C. , Kernstine Kemp H. 
Published: June 2009

AbstractBackgroundUsing a large data set, we investigated the impact of the number of resected and involved lymph nodes on overall survival for patients with esophageal cancer.MethodsFrom the National Oncology Database™, esophageal cancer cases with data available on the total number of resected and involved nodes as well as other variables were evaluated as it relates to overall survival by multivariate analysis using Cox proportional hazards method. Patients with 0, exactly 1 or 1–3 positive nodes were separately studied to determine the association between the number of lymph nodes resected and overall survival.ResultsFrom 1969 to 2002, 3,144 (17%) of 18,390 esophageal cancer cases with complete data were identified. Increasing number of involved nodes predicted poorer outcome (P < 10−6). Results from studying patients with 0, exactly 1 or 1–3 positive nodes showed that survival improved with increasing number of nodes analyzed up to 12. Three‐tier nodal grouping with increasing risk of death were identified, 0, 1–3, and ≥4 positive nodes (P < 10−5).ConclusionsThe pathological assessment of minimal 12 lymph nodes provides sufficient prognostic information. Three‐tier nodal grouping is suggested for the next version of AJCC staging system for esophageal cancer. J. Surg. Oncol. 2009;100:127–132. © 2009 Wiley‐Liss, Inc.
Modeling and prediction of retention behavior of histidine‐containing peptides in immobilized metal‐affinity chromatography
Authors: Tian Feifei , Yang Li , Lv Fenglin , Zhou Peng 
Published: June 2009

AbstractTwo kinds of structural characterization method as local descriptors and global descriptors were used to parameterize peptide structures, and several quantitative structure‐retention relationship models were then constructed using partial least square (PLS), least‐squares support vector machine (LS‐SVM) and Gaussian process (GP) coupled with genetic algorithm‐variable selection. These models were validated rigorously and investigated systematically by Tropsha et al. criteria, Monte Carlo cross‐validation and one‐way analysis of variance. Results show that regression models constructed using nonlinear approaches such as LS‐SVM and GP are more robust and predictable than those by linear PLS method. By including linear and nonlinear terms in the covariance function, the GP is capable of handling both linear and nonlinear‐mixed relationship, and thus presents a better performance than LS‐SVM. Investigation of the optimal GP model revealed that diversified properties contribute to the retention behavior of peptides in immobilized metal‐affinity chromatography. Particularly, coordination interaction, electrostatic factor, sovlation effect and hydrogen bonding are correlated significantly with the peptide retention ability.
Quantification of domoic acid in shellfish tissues by pressurized capillary electrochromatography
Authors: Wu Weimin , Wu Xiaoping , Lin Xucong , Xie Zenghong , Giesy John P. 
Published: June 2009

AbstractA method was developed to quantify domoic acid (DA), the chemical responsible for amnesic shellfish poisoning (ASP), by pressurized CEC (pCEC). The effect of different experimental conditions on the separation of DA and matrix solutes, such as the content of ACN in mobile phase, pH and concentration of buffer, supplementary pressure and applied voltage, were investigated. Under the optimal conditions, the pCEC method separated DA from shellfish matrices within 6 min. By using supplementary pressure, bubble formation in the capillary column was completely suppressed. The method was repeatable, sufficient accurate and sensitive for rapid screening of DA in shell seafood.