bluuebunny/crossref_metadata_2025_split huggingface dataset:
On-site evaluation of the ‘mechanical’ properties of Maastricht limestone and their relationship with the physical characteristics
Authors: Rescic S. , Fratini F. , Tiano P. 
Published: March 2010

Abstract
Maastricht limestone is a soft bioclastic calcarenite of the Upper Cretaceous period cropping out in southern Limburg between Belgium and The Netherlands. This material was widely used from the Middle Ages to the Renaissance. Four different varieties can be distinguished according to fossil content and petrographic characteristics, which determine slight differences in compressive strength. Despite its poor mechanical characteristics, the material is very durable with remarkable frost resistance. This is mainly due to the pore dimensions (the most frequent pore radius class is 16–64 µm) but also to the particular kind of weathering that causes the formation of a protective ‘skin’ through a process of dissolution of unstable aragonite from serpulids and calcite precipitation in the pores of the external layer. The physical characteristics and the mechanical properties (using the drilling resistance measurement system (DRMS) method) of the hard layer that developed on the surface of Tongeren Cathedral, constructed using the Sibbe variety of Maastricht limestone, were investigated and compared with those of the quarry material. This comparison made it possible to emphasize the particular hardness of this surface in contrast to the outer layer of the quarry material. Moreover, it was possible to determine its thickness and to infer that this hard layer was formed after only 15 years of exposure.
Primary bioreceptivity of limestones used in southern European monuments
Authors: Miller Ana Z. , Leal Nuno , Laiz Leonila , Rogerio-Candelera Miguel A. , Silva Rui J. C. , Dionísio Amélia , Macedo Maria F. , Saiz-Jimenez Cesareo 
Published: March 2010

Abstract

Different Mediterranean Basin limestones, like
Calcário Ançã
(Portugal),
Calcário Lioz
(Portugal),
Piedra San Cristobal
(Spain),
Piedra Escúzar
(Spain) and
Pietra di Lecce
(Italy), have been widely used as building materials in the European architecture. The aim of this study was focused on biodeterioration, mainly on evaluation of the primary bioreceptivity of those materials. A set of samples was inoculated with a cultured photosynthetic biofilm under laboratory conditions. Several assessment tools were applied to monitor the colonization overtime of the different lithotypes. After 3 months of incubation the colonization occurred endolithically in some lithotypes, namely
Piedra San Cristobal
and
Piedra Escúzar
. Spectrophotometric determination of chlorophyll
a
was a useful analytical technique to achieve the total amount of photosynthetic biomass on rock substrates, demonstrating that
Piedra Escúzar
and
Calcário Lioz
were the highest and lowest bioreceptive lithotypes, respectively. Microscopic and image analyses were essential to understand the stone colonization process and its pattern of distribution. Physical stone parameters and exposure conditions were shown to play an important role in the establishment and development of photosynthetic colonization.
Approaches to the problem of limestone replacement in Greece
Authors: Stefanidou M. A. 
Published: March 2010

Abstract
One of the most common stone types in building construction in Greece is limestone. Whole structures such as castles, palaces, fortresses and churches were built only with limestone blocks or limestone pieces combined with other types of stone. In this paper two types of limestone (a biogenic limestone and a travertine) used in the construction of monuments are tested and analysed in terms of their physical, mechanical and microstructural characteristics in order to record their properties. Their exposure to different environmental conditions and the pathology forms they present are also recorded. The possibility of their replacement is approached either by supplementing the missing parts, by finding a comparable new stone or by applying an artificial one. The results of the study performed in each case are also presented.
Homocysteine and arterial thrombosis: Challenge and opportunity
Authors: Tremoli Elena , Coppola Antonio , Lupoli Roberta , Minno Giovanni Di , Di Minno Matteo 
Published: March 2010

SummaryThe correlation between homocysteine and vascular disease has been assessed in several clinical studies that demonstrated that elevation of plasma total homocysteine (tHcy) was an independent risk factor for atheriosclerotic disease. Major advances of homocysteine metabolism disorders have been made during the last few years, encompassing the rare homozygous enzyme deficiencies, as well as more common milder abnormalities. In experimental and clinical studies, a homocysteine-mediated oxidant stress has been shown to trigger platelet activation, in turn leading to a tendency to thrombosis, in patients with severe hyperhomocysteinaemia. Likewise, the hypomethylation hypothesis on acquired hyperhomocysteinaemia (chronic renal disease) and the interrelationship between hyperhomocysteinaemia and impaired fibrinolysis, have added further biological plausibility to the role for hyperhomocysteinaemia in vascular medicine. However, whether hyperhomocysteinaemia is causal or a marker of vascular disease, and whether plasma tHcy is only an indicator of the metabolic status remains to be clarified. The role of the intake of some vitamins (folic acid, vit.B12, vit.B6) on cardiovascular disease (CVD) is poorly understood: in spite of the lowering of homocysteine (Hcy) levels, vitamin supplementation failed to exert significant effects on cardiovascular risk. On the other hand, although some lipid-modifying treatments increase Hcy levels in diabetics, there is no evidence that this attenuates the beneficial effects of such treatments on the cardiovascular risk. Because of these uncertainties in the area, the data available do not provide support for routine screening and treatment for elevated Hcy to prevent CVD.
Differential effect of ischaemic preconditioning on mobilisation and recruitment of haematopoietic and mesenchymal stem cells in porcine myocardial ischaemia-reperfusion
Authors: Posa Aniko , Pavo Noemi , Hemetsberger Rayyan , Kvakan Heda , Steiner-Böker Sabine , Petrási Zsolt , Manczur Ferenc , Pavo Imre , Èdes István , Wojta Johann , Glogar Dietmar , Huber Kurt , Gyöngyösi Mariann 
Published: March 2010

SummaryEffects of ischaemic preconditioning (IP) on the mobilisation and recruitment of haematopoietic (HSCs) and mesenchymal stem (MSC) cells were determined in porcine coronary occlusion/reperfusion. Thirtythree pigs underwent percutaneous occlusion of the left anterior descending coronary artery (LAD) for 90 minutes (min), followed by 120 min reperfusion. IP was performed in 16 of the 33 pigs by two cycles of 5 min balloon occlusion/reperfusion prior to the 90 min occlusion (group IP vs. group C). Peripheral blood and myocardial tissue concentration of bone marrow origin HSCs (characterised by coexpression of CD31+, CD90+, CD45+) and MSCs (characterised by coexpression of CD44+, CD90+, CD45-) were measured by flow cytometry in the early phase of IP. Plasma/serum levels of stem cell mobilisation factors (stromal cell-derived factor-1α [SDF-1α], vascular endothelial growth factor [VEGF], tumour necrosis factor α[TNF-α] and interleukin-8 [IL-8]) were measured. IP led to a significant increase in circulating HSCs as compared with the group C (475 ± 233 vs. 281 ± 264 /μl, p=0.032) in the early phase of IP. In contrast, a rapid and prolonged decrease in level of circulating MSCs was observed in group IP as compared with group C (19 ± 12 vs. 32 ± 17 /μl, p=0.015). The recruitment of HSCs and MSCs in infarct and border zone was significantly greater in IP group, indicating a faster homing of MSCs as compared with the rate of mobilisation. Rapid increase in VEGF, TNF-α and IL-8 levels was induced by IP, which, however, was not correlated with the levels of circulating SCs. In conclusion, IP resulted in differential mobilisation and recruitment of HSCs and MSCs in the early phase of cardioprotection.
Validation of claims-based diagnostic codes for idiopathic thrombotic thrombocytopenic purpura in a commercially-insured population
Authors: Terrell Deirdra , George James , Rodgers J. Keith , Uhl Lynn , Cataland Spero , Bohn Rhonda , Wahl Peter 
Published: March 2010

SummaryIt was the purpose of the present study to validate administrative claims codes for idiopathic thrombotic thrombocytopenic purpura (TTP) in a commercially-insured US population. Patients with at least one medical claim with ICD-9 code 446.6X between 1/1/2001 and 5/31/2008 were identified in the HealthCore Integrated Research Database™ (HIRD). A chart abstraction form was developed to enable case determination for patients identified by the claims code. Two clinical experts, not involved in the design of the study, reviewed the abstracted medical record data and determined whether definite evidence supporting the diagnosis of TTP was present. The positive predictive value (PPV) of the claims coding algorithm for cases assessed by both reviewers was computed. The claims algorithm was further refined and the PPV of the refined algorithm was computed. One hundred eighty-nine abstracted charts were reviewed by two clinical experts; 86 were assessed to have definite evidence supporting the diagnosis of TTP (PPV 45.5% [86/189; 95% confidence interval (CI), 38.3–52.9%]). Refinement of the claims algorithm first included the use of plasma exchange treatment, resulting in 103 potential cases, of which 67 were assessed to have definite evidence supporting the diagnosis of TTP (PPV 65.0%; 95% CI, 55.0–74.2%). Further refinement of the claims algorithm ruled out alternative diagnoses that may mimic TTP; 34 were assessed to have definite evidence supporting the diagnosis of TTP (PPV 72.3% [34/47; 95% CI, 57.4–84.4%]).Our findings demonstrate the difficulty of confirming the diagnosis of rare disorders that lack definite diagnostic criteria, and indicate that more complex claims coding algorithms are necessary for identifying these disorders.
Activated monocytes capture platelets for heterotypic association in patients with severe carotid artery stenosis
Authors: Schriek Carsten , Aken Hugo Van , Droste Dirk , Ringelstein E. Bernd , Jurk Kerstin , Ritter Martin , Kehrel Beate 
Published: March 2010

SummaryInflammation and thrombosis, two processes influencing each other, are involved in the pathogenesis of cerebrovascular disease. We showed that in patients with acute ischaemic stroke circulating platelets are activated and exhausted. To identify whether activated haemostasis might be cause or effect, we investigated the role of leukocyte and platelet activation in patients with severe asymptomatic and symptomatic carotid artery disease. Flow cytometry analysis demonstrated that monocytes from symptomatic (acute stroke aetiology) and asymptomatic patients were highly activated, shown by significantly enhanced presentation of inflammatory markers CD11b and thrombospondin-1 (TSP-1) on the surface. Both correlated positively with monocyte-platelet association rate. However, increased monocyte activation and elevated levels of monocyte-platelet associates in asymptomatic patients were restricted to patients with echo-lucent plaques, providing a close link between monocyte activation and plaque morphology. Circulating single as well as monocyte-bound platelets from symptomatic patients showed significantly enhanced surface expression of P-selectin and TSP-1, whereas platelets from asymptomatic patients were not significantly activated. These results indicate that monocytes activated by inflammation rather than platelets might be the candidates to initiate platelet-monocyte rosetting during the pathogenesis of atherothrombotic cerebral ischaemia and that haemostasis might be activated secondarily by the first occurring inflammation.
Leukocyte count and risk of thrombosis in patients undergoing haematopoietic stem cell transplantation or intensive chemotherapy
Authors: Buser Andreas , Gratwohl Alois , Stern Martin , Stoffel Nadina , Rysler Christine , Tsakiris Dimitrios 
Published: March 2010

SummaryElevated white blood cell count has recently been established as an independent risk factor for thromboembolic events in patients with myeloproliferative syndromes. Thrombotic events occur frequently in patients with haematological malignancies undergoing intensive cytoreductive treatment. We evaluated retrospectively the association of leukocyte counts and thrombosis in three cohorts of 100 patients each undergoing autologous or allogeneic haematopoietic stem cell transplantation or chemotherapy, respectively. A total of 26 thromboembolic events were recorded, 10 in recipients of allogeneic transplants, five in autografted patients, and 11 in the chemotherapy group. Fifteen events were central venous catheter related. Non-catheter related thrombotic events were pulmonary embolism (N=5), hepatic veno-occlusive disease (N=2), deep-vein thrombosis (N=1), stroke (N=1), ovarian vein thrombosis (N=1), and left ventricular thrombosis (N=1). Hazard rates showed two peaks, a first during cytoreduction in all groups, and a second after engraftment in transplanted patients. Time-dependent multivariable Cox analysis confirmed an association of leukocytosis with development of thrombosis (hazard ratio for leukocyte count > 11G/l: 9.73, 95% confidence interval 1.98–47.9, p=0.005). The risk associated with leukocytosis was independent from C-reactive protein level. Thrombocyte count and type of treatment (allogeneic vs. autologous transplantation vs. chemotherapy) had no significant influence on thrombosis development. In three cohorts of patients undergoing intensive cytoreductive treatment for haematological malignancy, leukocyte count was strongly associated with development of thrombotic complications.
Heterozygous antithrombin deficiency improves in vivo haemostasis in factor VIII-deficient mice
Authors: Bolliger Daniel , Szlam Fania , Suzuki Nobuaki , Matsushita Tadashi , Tanaka Kenichi 
Published: March 2010

SummaryDecreased levels of factor VIII (FVIII) limit the amount of thrombin generated at the site of injury, but not the rate that thrombin is neutralised by antithrombin (AT). We hypothesised that FVIII-deficient mice with heterozygous AT deficiency will demonstrate increased thrombin generation and therefore less in vivo bleeding compared to FVIII-deficient mice with normal AT levels. Therefore, we performed tail bleeding experiments in wild-type (WT), heterozygous AT deficient (AT+/-) mice, FVIII-deficient (FVIII-/-) mice, and FVIII-deficient mice with heterozygous AT deficiency (FVIII-/-/AT+/-). Amount of bleeding was assessed by measuring absorbance of haemoglobin released from lysed red blood cells collected after tail transection. In addition, we measured thrombin generation, activated partial thromboplastin time (aPTT), and AT activity in plasma from the different mice groups. Tail bleeding was significantly reduced in FVIII-/-/AT+/- mice compared to FVIII-/- mice. On the other hand, there was no difference in tail bleeding between AT+/- and wild-type mice. Thrombin generation was dependent on the mice geno-type, and increased in the following order: FVIII-/- < FVIII-/-/AT+/- < WT < AT+/-. The aPTT was not influenced by reduced AT activity (i.e. AT+/- genotype), but was significantly prolonged in FVIII-/- and FVIII-/-/AT+/- mice. Using FVIII-deficient mice as an in vivo murine model of reduced thrombin generation, we demonstrated that moderately reduced AT levels increase thrombin generation and decrease bleeding after traumatic tail vessel injury. In agreement with congenital thrombotic conditions, our data elucidate that bleeding phenotypes can be modulated by the balance between procoagulant and anticoagulant proteins.
Picture Superiority Doubly Dissociates the ERP Correlates of Recollection and Familiarity
Authors: Curran Tim , Doyle Jeanne 
Published: March 2010

Abstract
Two experiments investigated the processes underlying the picture superiority effect on recognition memory. Studied pictures were associated with higher accuracy than studied words, regardless of whether test stimuli were words (Experiment 1) or pictures (Experiment 2). Event-related brain potentials (ERPs) recorded during test suggested that the 300–500 msec FN400 old/new effect, hypothesized to be related to familiarity-based recognition, benefited from study/test congruity, such that it was larger when study and test format remained constant than when they differed. The 500–800 msec parietal old/new effect, hypothesized to be related to recollection, benefited from studying pictures, regardless of test format. The parallel between the accuracy and parietal ERP results suggests that picture superiority may arise from encoding the distinctive attributes of pictures in a manner that enhances their later recollection. Furthermore, when words were tested, opposite effects of studying words versus studying pictures were observed on the FN400 (word &gt; picture) versus parietal (picture &gt; word) old/new effects—providing strong evidence for a crossover interaction between these components that is consistent with a dual-process perspective.
General-Purpose Monitoring during Speech Production
Authors: Riès Stéphanie , Janssen Niels , Dufau Stéphane , Alario F.-Xavier , Burle Borís 
Published: March 2010

AbstractThe concept of “monitoring” refers to our ability to control our actions on-line. Monitoring involved in speech production is often described in psycholinguistic models as an inherent part of the language system. We probed the specificity of speech monitoring in two psycholinguistic experiments where electroencephalographic activities were recorded. Our focus was on a component previously reported in nonlinguistic manual tasks and interpreted as a marker of monitoring processes. The error negativity (Ne, or error-related negativity), thought to originate in medial frontal areas, peaks shortly after erroneous responses. A component of seemingly comparable properties has been reported, after errors, in tasks requiring access to linguistic knowledge (e.g., speech production), compatible with a generic error-detection process. However, in contrast to its original name, advanced processing methods later revealed that this component is also present after correct responses in visuomotor tasks. Here, we reported the observation of the same negativity after correct responses across output modalities (manual and vocal responses). This indicates that, in language production too, the Ne reflects on-line response monitoring rather than error detection specifically. Furthermore, the temporal properties of the Ne suggest that this monitoring mechanism is engaged before any auditory feedback. The convergence of our findings with those obtained with nonlinguistic tasks suggests that at least part of the monitoring involved in speech production is subtended by a general-purpose mechanism.
Role for Presupplementary Motor Area in Inhibition of Cognitive Set Interference
Authors: Konishi Seiki , Watanabe Takamitsu , Jimura Koji , Chikazoe Junichi , Hirose Satoshi , Kimura Hiroko M. , Miyashita Yasushi 
Published: March 2010

Abstract
Proactive interference (PI), which is formed through repetition of certain behavior and lasts for a while, needs to be inhibited in order for subsequent behavior to prevail over the antecedent one. Although the inhibitory mechanisms in the pFC have been reported that are recruited long after one behavior is updated to another, very little is known about the inhibitory mechanisms that are recruited immediately after the update. The WCST was modified in the present fMRI study such that inhibition of PI could be examined both immediately after and long after update of behavior. Use of “dual-match” stimuli allowed us to compare two types of trials where inhibition of PI was and was not required (control and release trials, respectively). Significant activation was observed in the left pre-SMA during control versus release trials. The pre-SMA activation was selective to PI inhibition required immediately after update of behavior, which exhibited marked contrast to the left anterior prefrontal activation selective to PI inhibition required long after the update. These results reveal dissociable inhibitory mechanisms in these two regions that are recruited in the different temporal contexts of the inhibitory demands imposed during performance of the task.
Contextual Priming in Grapheme–Color Synesthetes and Yoked Controls: 400 msec in the Life of a Synesthete
Authors: Brang David , Kanai Stanley , Ramachandran Vilayanur S. , Coulson Seana 
Published: March 2010

Abstract
Grapheme–color synesthesia is a heritable trait where graphemes (“2”) elicit the concurrent perception of specific colors (red). Researchers have questioned whether synesthetic experiences are meaningful or simply arbitrary associations and whether these associations are perceptual or conceptual. To address these fundamental questions, ERPs were recorded as 12 synesthetes read statements such as “The Coca-Cola logo is white and 2,” in which the final grapheme induced a color that was either contextually congruous (red) or incongruous (“…white and 7,” for a synesthetes who experienced 7 as green). Grapheme congruity was found to modulate the amplitude of the N1, P2, N300, and N400 components in synesthetes, suggesting that synesthesia impacts perceptual as well as conceptual aspects of processing. To evaluate whether observed ERP effects required the experience of colored graphemes versus knowledge of grapheme–color pairings, we ran three separate groups of controls on a similar task. Controls trained to a synesthete's associations elicited N400 modulation, indicating that knowledge of grapheme–color mappings was sufficient to modulate this component. Controls trained to synesthetic associations and given explicit visualization instructions elicited both N300 and N400 modulations. Lastly, untrained controls who viewed physically colored graphemes (“2” printed in red) elicited N1 and N400 modulations. The N1 grapheme congruity effect began earlier in synesthetes than colored grapheme controls but had similar scalp topography. Data suggest that, in synesthetes, achromatic graphemes engage similar visual processing networks as colored graphemes in nonsynesthetes and are in keeping with models of synesthesia that posit early feed-forward connections between form and color processing areas in extrastriate cortex. The P2 modulation was unique to the synesthetes and may reflect neural activity that underlies the conscious experience of the synesthetic induction.
Phonological Neighborhood Effects in Spoken Word Production: An fMRI Study
Authors: Peramunage Dasun , Blumstein Sheila E. , Myers Emily B. , Goldrick Matthew , Baese-Berk Melissa 
Published: March 2010

AbstractThe current study examined the neural systems underlying lexically conditioned phonetic variation in spoken word production. Participants were asked to read aloud singly presented words, which either had a voiced minimal pair (MP) neighbor (e.g., cape) or lacked a minimal pair (NMP) neighbor (e.g., cake). The voiced neighbor never appeared in the stimulus set. Behavioral results showed longer voice-onset time for MP target words, replicating earlier behavioral results [Baese-Berk, M., & Goldrick, M. Mechanisms of interaction in speech production. Language and Cognitive Processes, 24, 527–554, 2009]. fMRI results revealed reduced activation for MP words compared to NMP words in a network including left posterior superior temporal gyrus, the supramarginal gyrus, inferior frontal gyrus, and precentral gyrus. These findings support cascade models of spoken word production and show that neural activation at the lexical level modulates activation in those brain regions involved in lexical selection, phonological planning, and, ultimately, motor plans for production. The facilitatory effects for words with MP neighbors suggest that competition effects reflect the overlap inherent in the phonological representation of the target word and its MP neighbor.