bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential impact of tumor registry rule changes for recording inflammatory breast cancer
Authors: Taylor Sarah H. , Walters Ronald 
Published: May 2010

AbstractBACKGROUND:New tumor registry rules for abstracting multiple primaries and histologies include 1 specifically for inflammatory breast cancer (IBC), which states that the International Classification for Oncology (ICD‐O) histology code 8530 (3) for IBC should be used only when it is on the pathology report. IBC is typically clinically diagnosed. The purpose of this project is to determine the potential impact of this new rule on identifying IBC cases by searching on the ICD‐O histology code.METHODS:Two hundred forty patients were identified from The University of Texas M. D. Anderson Cancer Center Tumor Registry database, who had initially presented to the institution from 2005 through 2007 with a diagnosis of IBC.RESULTS:The basis of diagnosis of IBC was pathologic for 73 patients and clinical for 167. Of the 167 patients with a clinical diagnosis of IBC, 164 patients also had a pathologic diagnosis of a non‐IBC histology. Following the new rule, the non‐IBC histology would be recorded for these 164 patients.CONCLUSIONS:Based on the analysis of The University of Texas M. D. Anderson Cancer Center's patients with IBC, the new Surveillance, Epidemiology, and End Results multiple primary rule will result in the ICD‐O IBC histology code being recorded for approximately 30% of patients with IBC. Clinically diagnosed cases are to be identified using the collaborative staging extension codes or the American Joint Committee on Cancer/TNM classification T value of 4 days. However, many researchers may continue to search only on the histology field, resulting in a perceived decrease in IBC. Cancer 2010;116(11 suppl):2745–7. © 2010 American Cancer Society.
Suberoylanilide hydroxamic acid blocks self‐renewal and homotypic aggregation of inflammatory breast cancer spheroids
Authors: Robertson Fredika M. , Woodward Wendy A. , Pickei Ross , Ye Zaiming , Bornmann William , Pal Ashutosh , Peng Zhenghong , Hall Carolyn S. , Cristofanilli Massimo 
Published: May 2010

AbstractBACKGROUND:Inflammatory breast cancer (IBC) is the most aggressive form of locally advanced breast cancer (LABC). Patients with IBC commonly present with skin metastasis, which are observed microscopically as tumor emboli within dermal lymphatics. These metastatic tumor cells aberrantly overexpress E‐cadherin and exhibit the ability to undergo self‐renewal and are highly invasive. There are no therapeutics yet identified that target the structure and functions of IBC tumor emboli. The present studies evaluated the effects of the pan‐histone deacetylase (HDAC) inhibitor suberoylanilide hydroxamic acid (SAHA) using IBC tumor spheroids derived from established IBC cell lines and tumor spheroids derived from pleural effusion (PE) aspirates of patients with IBC and LABC, designated as PE‐IBC and PE‐LABC.METHODS:Methods used are as follows: culture of IBC cells from clonal density single cells in low adherence culture conditions that promote formation of IBC tumor spheroids; clonogenic assays; cell fractionation and Western blotting; confocal microscropy; and modified Boyden chamber invasion assays.RESULTS:SAHA inhibited self‐renewal of IBC tumor spheroids from established IBC cell lines and PE‐IBC and PE‐LABC, as assessed by decreased clonogenic growth. SAHA blocked homotypic aggregation of the cells that comprised the IBC tumor spheroids leading to loss of their 3‐dimensional (3D) structure, which was associated with a change in location of E‐cadherin protein from the plasma membrane in untreated IBC tumor spheroids to the cytoplasm of cells within IBC tumor spheroids with SAHA treatment. In addition, SAHA blocked the robust invasion exhibited by IBC tumor spheroids of established cell lines as well as by tumor spheroids derived from PE‐IBC and PE‐LABC.CONCLUSIONS:SAHA targets the integrity and biological activities of IBC tumor spheroids and may be a promising agent to evaluate for its effectiveness in treatment of IBC. Cancer 2010;116(11 suppl):2760–7. © 2010 American Cancer Society.
Inflammatory breast cancer—The Royal Marsden Hospital experience
Authors: Sutherland Stephanie , Ashley Sue , Walsh Geraldine , Smith Ian E. , Johnston Stephen R. D. 
Published: May 2010

AbstractBACKGROUND:Treatments for inflammatory breast cancer (IBC) have changed over the last 15 to 20 years. The authors of this report undertook a retrospective review of patients who were treated at the Royal Marsden Hospital (RMH) to determine whether recurrence‐free survival (RFS) and overall survival (OS) have improved as treatment regimens have altered.METHODS:Detailed clinical‐pathologic data were collected on patients who were treated for primary IBC at RMH between 1990 and 2007. A Cox regression model was used to investigate the factors that influenced OS.RESULTS:The median OS was 3 years and 4 months, and the median RFS was 1 year and 10 months. RFS was better in patients who had received taxane‐containing regimens; however, there was no OS benefit. A pathologic complete response (pCR) was observed in 13 of 89 patients (15%), and those who achieved a pCR had significantly better RFS but no improvement in OS. The type of chemotherapy did not affect the pCR rate. One hundred thirty of 155 patients received radiotherapy, and those who did not receive radiotherapy had significantly worse outcomes. A multivariate Cox regression analysis indicated that the date of diagnosis, estrogen receptor (ER) status, and the presence of metastatic disease at diagnosis were significant prognostic factors. Patients who were diagnosed during or after 2000 had a relative risk of mortality of 0.5 compared with patients who were diagnosed before 2000. ER‐positive patients had a median OS of 4.5 years and a median of RFS of 2.6 years versus 2.9 years and 1.4 years, respectively, for ER‐negative patients. Patients who had metastatic disease at presentation had an OS of 1.7 years versus 3.9 years for those without metastatic disease at presentation.CONCLUSIONS:Achieving a pCR improved RFS but had no impact on OS. Patients who had metastatic disease at the outset fared much worse, and positive ER status conferred a better outlook. Cancer 2010;116(11 suppl):2815–20. © 2010 American Cancer Society.
Human mammary tumor virus in inflammatory breast cancer
Authors: Pogo Beatriz G.‐T. , Holland James F. , Levine Paul H. 
Published: May 2010

AbstractThe authors have found that retroviral sequences with 85% to 95% homology to the mouse mammary tumor virus were present in 40% of the sporadic breast cancers of American women. These sequences were not found in normal breasts or other tumors. A whole proviral structure was detected in 2 tumors. Breast cancer cells in culture were shown to contain and shed betaretroviral particles. This virus was designated human mammary tumor virus (HMTV). The authors have investigated the presence of HMTV sequences in a variety of breast conditions and geographic locations. Here they report that inflammatory breast cancer from American women shows a higher incidence of viral sequences (71%) than sporadic breast cancers. Similar incidence has been found in inflammatory breast cancers from Tunisia, and in gestational breast cancers. Because these conditions represent highly invasive malignancies, it is concluded that HMTV is sometimes associated with a particularly malignant phenotype. Cancer 2010;116(11 suppl):2741–4. © 2010 American Cancer Society.
Atrioventricular conduction and arrhythmias at the initiation of beating in embryonic mouse hearts
Authors: Chen Fuhua , De Diego Carlos , Chang Marvin G. , McHarg Jennifer L. , John Scott , Klitzner Thomas S. , Weiss James N. 
Published: May 2010

AbstractTo investigate cardiac physiology at the onset of heart beating in embryonic mouse hearts, we performed optical imaging of membrane potential (Vm) and/or intracellular calcium (Cai). Action potentials and Cai transients were detected in ∼50% of mouse embryo hearts at E8.5, but in all hearts at E9.0, indicating that beating typically starts between E8–E9. Beating was eliminated by Ca channel blocker nifedipine and the If blocker ZD7288, unaffected by tetrodotoxin and only mildly depressed by disabling sarcoplasmic (SR) and endoplasmic (ER) reticulum Ca cycling. From E8.5 to E10, conduction velocity increased from 0.2–1 mm/s to >5 mm/s in first ventricular and then atrial tissue, while remaining slow in other areas. Arrhythmias included atrioventricular reentry induced by adenosine. In summary, at the onset of beating, If‐dependent pacemaking drives both AP propagation and Cai transient generation through activation of voltage‐dependent Ca channels. Na channels and intracellular Ca cycling have minor roles. Developmental Dynamics 239:1941–1949, 2010. © 2010 Wiley‐Liss, Inc.
A circulatory transcriptional regulation among daf‐9, daf‐12, and daf‐16 mediates larval development upon cholesterol starvation in Caenorhabditis elegans†
Authors: Jeong Myung‐Hwan , Kawasaki Ichiro , Shim Yhong‐Hee 
Published: May 2010

AbstractC. elegans shows dauer‐like larvae formation upon cholesterol starvation (CS), but the genetic epistasis among abnormal dauer formation (daf) genes during the process remains unclear. To clarify the genetic interactions among daf‐9, daf‐12, and daf‐16 in this process, mRNA levels of these genes upon CS were measured. CS increased the mRNA levels of daf‐9, daf‐12, and daf‐16. CS also induced DAF‐16 nuclear localization, which was positively and negatively regulated by DAF‐12 and DAF‐9 activities, respectively. Activated DAF‐16, a FOXO transcription factor, enhanced daf‐12 but suppressed daf‐9 expression, whereas DAF‐9 inhibited daf‐12 expression. Concomitantly, CS‐induced larval arrest was regulated positively by DAF‐12 and DAF‐16, but negatively by DAF‐9. The larval arrest in daf‐9 mutant was suppressed by daf‐12 RNAi, placing DAF‐12 downstream of DAF‐9. These results altogether suggest that circulatory mutual regulation among daf‐9, daf‐12, and daf‐16 at the expression level mediates cholesterol signal to control larval development upon CS. Developmental Dynamics 239:1931–1940, 2010. © 2010 Wiley‐Liss, Inc.
Ion imaging during axolotl tail regeneration in vivo
Authors: Özkucur Nurdan , Epperlein Hans‐Henning , Funk Richard H.W. 
Published: May 2010

AbstractSeveral studies have reported that endogenous ion currents are involved in a wide range of biological processes from single cell and tissue behavior to regeneration. Various methods are used to assess intracellular and local ion dynamics in biological systems, e.g., patch clamping and vibrating probes. Here, we introduce an approach to detect ion kinetics in vivo using a noninvasive method that can electrophysiologically characterize an entire experimental tissue region or organism. Ion‐specific vital dyes have been successfully used for live imaging of intracellular ion dynamics in vitro. Here, we demonstrate that cellular pH, cell membrane potential, calcium, sodium and potassium can be monitored in vivo during tail regeneration in the axolotl (Ambystoma mexicanum) using ion‐specific vital dyes. Thus, we suggest that ion‐specific vital dyes can be a powerful tool to obtain electrophysiological data during crucial biological events in vivo. Developmental Dynamics 239:2048–2057, 2010. © 2010 Wiley‐Liss, Inc.
Visualization of embryonic lymphangiogenesis advances the use of the zebrafish model for research in cancer and lymphatic pathologies
Authors: Flores Maria Vega , Hall Christopher J. , Crosier Kathryn E. , Crosier Philip S. 
Published: May 2010

AbstractLymphangiogenesis induced during tumor growth contributes to metastasis. Genetic and chemical screens using the zebrafish model have the potential to enhance our understanding of lymphangiogenesis, and lead to the discovery of pharmacological agents with activity in the lymphatic system. Large‐scale screening of lymphatic development in the whole zebrafish embryo requires a specific lymphatic endothelial cell marker. We isolated the zebrafish ortholog of Lyve1, and analyzed its expression pattern during embryogenesis, and under conditions where key regulators of lymphangiogenesis such as Prox1 and VegfC were depleted. Like humans, zebrafish embryos form lymph sacs, lymphangioblasts arise from venous endothelia, and they form asymmetric left and right collecting ducts. By monitoring the earliest lymphatic sprouting in the head, a pilot drug assay was performed showing rapamycin, an inhibitor of mammalian lymphangiogenesis, can also suppress zebrafish lymphangiogenesis. This work opens up a novel opportunity to further the understanding of, and potentially manipulate, human lymphangiogenesis. Developmental Dynamics 239:2128–2135, 2010. © 2010 Wiley‐Liss, Inc.
Metal Cation Controlled Supramolecular Assembly of 1‐Butyl‐4,4′‐bipyridinium and Cucurbit[8]uril
Authors: Xiao Xin , Liu Jing‐Xin , Chen Kai , Zhu Qian‐Jiang , Xue Sai‐Feng , Tao Zhu 
Published: May 2010

AbstractThree supramolecular assemblies [(C14H17N2)2⊂C48H48N32O16]Cl2·23H2O (1), {[C14H17N2Cu(H2O)5]2⊂C48H48N32O16}[(C14H17N2)2⊂C48H48N32O16]Cl4(NO3)4·32H2O (2), and {[C14H17N2Ni(H2O)5]2⊂C48H48N32O16}[(C14H17N2)2⊂C48H48N32O16]Cl2(NO3)6·22H2O (3) were synthesized in aqueous solution and characterized by X‐ray diffraction. The crystal structures of these supramolecular assemblies show that Q[8] can selectively encapsulate either the bipyridinium or butyl moiety of the 1‐butyl‐4,4′‐bipyridinium guest in its hydrophobic cavity to form ternary complexes through the influence of metal–ligand coordination. The main driving force of the selective formation of these supramolecular assemblies may be due to ion–dipole interactions.
Luminescent CaWO4:Tb3+‐Loaded Mesoporous Silica Composites for the Immobilization and Release of Lysozyme
Authors: Huang Shanshan , Li Chunxia , Yang Piaoping , Zhang Cuimiao , Cheng Ziyong , Fan Yong , Lin Jun 
Published: May 2010

AbstractLuminescence‐functionalized silica composites were synthesized by deposition of CaWO4:Tb3+ nanoparticles onto mesoporous silica (MS) materials by a Pechini‐type sol–gel process. The pristine mesoporous silica materials comprise rod‐like and spherical SBA‐15‐type silica materials in micron size, hollow silica spheres of around 2–4 μm, and silica tubes with lengths of tens of micrometers. The X‐ray diffraction (XRD), transmission electron microscopy (TEM), and N2 adsorption/desorption results confirm that the composites still conserve regular mesopore structure after the incorporation of the CaWO4:Tb3+ nanoparticles. These luminescent composites possessing suitable pore size, high BET surface area, and large pore volume (> 1.0 cm3/g) were studied as supports for immobilization of lysozymes. These composites show various lysozyme adsorption capacities at different solution pH values. CaWO4:Tb3+‐loaded SBA‐15‐type composites and hollow spheres adsorb relatively high amounts (> 500 mg/g composite at a solution pH of 10.0) of lysozyme (LYZ). The different enzyme adsorption and release properties of these luminescent mesoporous silica materials make them good candidates for specific bioimmobilization hosts. The emission intensity of Tb3+ in the CaWO4:Tb3+@rod‐like SBA‐15 varies with the total released amount of LYZ, which enables the lysozyme release to be tracked by the change in the luminescence intensity.
Novel O,O′‐Donor Oxo‐MoIV Hydrotris(3‐isopropylpyrazolyl)borate Complexes Formed by Chelation of Potentially Hydrogen‐Bonding Phenolate Ligands on Reduction of Dioxo‐MoVI Complexes
Authors: Ng Victor W. L. , Taylor Michelle K. , Hill Lyndal M. R. , White Jonathan M. , Young Charles G. 
Published: May 2010

AbstractThe oxo‐MoIV complexes formed in the reactions of cis‐TpiPrMoVIO2(OAr‐R) [TpiPr = hydrotris(3‐isopropylpyrazol‐1‐yl)borate, –OAr‐R = phenolate derivative] complexes with PEt3 or PEt2Ph in acetonitrile depend on the nature of the potential hydrogen‐bonding group (R) incorporated into the phenolate ligand. Green, diamagnetic, oxo(phosphoryl)‐MoIV complexes, TpiPrMoIVO(OAr‐R)(OPR′3), are produced when R is absent or is a non‐coordinating group such as 2‐OMe and 3‐NEt2; six‐coordinate TpiPrMoO(OC6H4OMe‐2)(OPEt3) was structurally characterized and exhibits a distorted octahedral geometry typical of such species. When R is a carbonyl functionality, complete oxygen atom transfer leads to green or purple, diamagnetic, chelate complexes of the type, TpiPrMoIVO(OAr‐R‐κ2O,O′). The R = 2‐COEt, 2‐CO2Me and 2‐CO2Ph derivatives exhibit six‐coordinate, distorted‐octahedral structures possessing fac TpiPr, terminal oxo and bidentate O,O′‐donor –OAr‐R ligands. Where R is an amido functionality, CONHPh, the complexes, TpiPrMoIVO(OC6H4CONHPh‐2‐κ2O,O′)·OPR′3 (R′3 = Et3, Et2Ph), are isolated. Here, the six‐coordinate, distorted‐octahedral complex forms an intermolecular NH···OPR′3 hydrogen bond to the lattice OPR′3 molecule. Thus, facile chelation of potential hydrogen‐bonding phenolate ligands suppresses hydrogen‐bond‐stabilized aquation or hydroxylation cis to the oxo group in these MoIV complexes.
Luminescent Hybrids Combining a Metal Complex and a Crown Ether – Receptors for Peptidic Ammonium Phosphates
Authors: Späth Andreas , Koch Carina , König Burkhard 
Published: May 2010

AbstractHybrid compounds combining a luminescent aza crown ether and 1,4,7,10‐tetraazacyclododecane (cyclene) or bis(pyridin‐2‐ylmethylamine) (bpa) metal complexes were prepared. These synthetic receptors signal the presence of peptidic ammonium phosphates in buffered aqueous solution by changes in their emission intensity. Reversible phosphate ion coordination to the metal complex binding sites decreases the emission intensity of the phthalic ester fluorophore. Structurally suitable ammonium phosphates, such as the C‐terminal domain of RNA polymerase II or the protein kinase G target sequence, bind to the synthetic receptors by an additional intramolecular interaction between the ammonium ion and the aza crown ether. The binding of the ammonium ion to the aza crown ether increases the emission intensity of the fluorophore. In aqueous solution, this weak interaction can only occur within aggregates of phosphates and metal complex receptors of matching geometry;therefore, it allows the distinction of structurally related phosphorylated peptides in buffered aqueous solution.
Low‐Temperature Synthesis of Meshy Boron Nitride with a Large Surface Area
Authors: Meng Xiang‐Lin , Lun Ning , Qi Yong‐Qiu , Bi Jian‐Qiang , Qi Yong‐Xin , Zhu Hui‐Ling , Han Fu‐Dong , Bai Yu‐Jun , Yin Long‐Wei , Fan Run‐Hua 
Published: May 2010

AbstractMeshy boron nitride (BN) was synthesized by the reaction of NaBH4 and CS(NH2)2 at 550 °C for 10 h. X‐ray diffraction indicates the formation of hexagonal boron nitride (h‐BN) with lattice constants a = 2.501 and c = 6.724 Å. Observations by TEM show that the BN obtained has a meshy structure with a quantity of pores distributing on each mesh. The nitrogen adsorption–desorption test gives a high surface area of 220 m2 g–1 for the meshy BN. The cathode‐luminescence spectrum exhibits a strong peak at 354 nm in the ultraviolet range. Thermogravimetric analysis proves that the meshy BN has good thermal stability and oxidation resistance up to 800 °C. The formation of meshy BN is due to the promotion of sulfur‐containing compounds for the cross‐linking of borazine and subsequent pyrolysis.
Synthesis, Structural, Redox and Mössbauer Characterization of Four‐Electron‐Oxidized Tetrakis(cyclohexyl)iron(II)porphodimethene with Different Axial Ligations
Authors: Bhattacharya Dibyendu , Sarkar Sabyasachi 
Published: May 2010

AbstractMonocationic FeIIporphodimethene complexes, [LΔΔFe–X][Y] {1, X = I–and Y = I3–;2, X = Br–and Y = [FeIIIBr4]–; LΔΔ= tetrakis(cyclohexyl)porphodimethene}, were achieved by induced electron‐transfer reactions between the square‐planar, intermediate‐spin, iron(III)porphyrinogen complex [Et4N][LFeIII] [L = tetrakis(cyclohexyl)porphyrinogen tetraanion] and different oxidants. Single‐crystal X‐ray diffraction analysis reveals that1and2have a square‐pyramidal geometry in which the iodide and bromide ligands occupy the axial position, respectively. Compound1exhibits an extended two‐dimensional solid‐state structure that comprises porphodimethene cation and triiodide anion chain columns in a 1:1 ratio, which are packed alternately. Electrochemical assessment with cyclic voltammetry reveals reversibly accessible FeII/IIIoxidation states; however, the redox potential is nearly one volt more positive than that for a typical heme cofactor, which suggests the highly oxidizing nature of the tetrapyrrole framework in the four–electron‐oxidized LΔΔmoiety. In addition, definitive experimental oxidation state and spin state assignments for the intermediate‐spin [Et4N][LFeIII] and high‐spin FeIIstates of1and2were afforded by Mössbauer characterization.
Advancing the Morita–Baylis–Hillman Chemistry of 1‐Formyl‐β‐carbolines for the Synthesis of Indolizino‐indole Derivatives
Authors: Singh Virender , Hutait Samiran , Batra Sanjay 
Published: May 2010

AbstractThe chemistry of the Morita–Baylis–Hillman adducts of 1‐formyl‐β‐carbolines has been extended for obtaining indolizino‐indole derivatives which mimic the harmicine and homofascaplysin frameworks. Adducts of N‐substituted methyl 1‐formyl‐9H‐β‐carboline‐3‐carboxylate yield indolizino‐indole derivatives upon bromination followed by aqueous workup. On the other hand, N‐substituted 1‐formyl‐9H‐β‐carbolines give rise to similar products in a one‐pot DABCO‐promoted reaction of activated alkenes. Alternatively, the DMAP‐mediated Morita–Baylis–Hillman reaction of N‐substituted methyl 1‐formyl‐9H‐β‐carboline‐3‐carboxylate with cycloalkenones yields adducts that cyclize intramolecularly in the presence of PBr3 to yield compounds with the homofascaplysin framework. In contrast, the DMAP‐mediated reaction of N‐substituted 1‐formyl‐β‐carboline with cyclohexenone directly gives a product with similar framework in a single step.
One‐Pot Synthesis of Azanucleosides from Proline Derivatives – Stereoselectivity in Sequential Processes
Authors: Boto Alicia , Hernández Dácil , Hernández Rosendo 
Published: May 2010

AbstractCommon amino acid derivatives can be transformed in one‐step fashion into N‐azanucleosides. The method is a sequential process initiated by a domino radical decarboxylation/oxidation reaction; an acyliminium ion is formed as an intermediate and can be trapped by nitrogen bases (purines, pyrimidines, and benzotriazole). The mildness of the reaction conditions and the good yields obtained make this procedure an interesting alternative to the conventional processes. Good stereoselectivities were obtained with 4‐(silyloxy)proline derivatives as substrates.
(–)‐Myrtenyl N,N‐Diisopropylcarbamate: Stereochemistry of Lithiation and Electrophilic Substitution Directed by Dynamic Kinetic Diastereoisomer Resolution
Authors: Hémery Thérèse , Becker Jochen , Fröhlich Roland , Hoppe Dieter 
Published: May 2010

Abstract(–)‐Myrtenyl N,N‐diisopropylcarbamate was lithiated bybutyllithium in the presence of achiral and chiral ligands, followed by quench with several electrophiles. The ratio of diastereomeric products allows conclusions regarding the configurational stability of both diastereomeric lithium intermediates and the influence of kinetic diastereoisomer resolution in the substitution step.