bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Stereoselective Reaction of Methylglyoxal with 2‐Aminopyridine and Adenine Derivatives: Formation of Imino Acid‐Nucleic Base Derivatives in Water under Mild Conditions.
Authors: Routaboul Christel , Dumas Lionel , Gautier‐Luneau Isabelle , Vergne Jacques , Maurel Marie‐Christine , Decout Jean‐Luc 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Convenient Synthesis of 5‐ and 8‐Nitroquinazoline‐2,4‐dione Derivatives.
Authors: Aziane D. , Soukri M. , El Hakmaoui A. , Lazar S. , Essassi E. M. , Guillaumet G. , Akssira M. 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
An Efficient, Convenient Synthesis of Novel Medium‐Sized 13H‐Dibenzo[d,h][1,3,7]oxadiazecine‐8,14‐dione Macrolides as Anticipated Antineoplastic Agents.
Authors: Abdel‐Hafez Atef Abdel‐Monem 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Regiocontrolled Reactions of Allylphosphonates: Syntheses of 1‐[(3‐Methoxycarbonyl)‐allyl]vinylphosphonates and 3‐Methoxycarbonyl‐1,3‐dienylphosphonates.
Authors: Shen Yanchang , Jiang Guo‐Fang 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
First Example of Construction of a Pyrrole Ring Bonded to a Steroid System by the Trofimov Reaction.
Authors: Vasil'tsov A. M. , Shmidt E. Yu. , Mikhaleva A. I. , Afonin A. V. , Zaitsev A. B. 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Syntheses of Bis(indolyl)‐Piperazine Alkaloids, Dragmacidin B and C, and Dihydrohamacanthin A.
Authors: Kawasaki Tomomi , Ohno Kohsuke , Enoki Hidetaka , Umemoto Yasuko , Sakamoto Masanori 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Design, Synthesis, and Antiproliferative Activity of Some New Pyrazole‐Fused Amino Derivatives of the Pyranoxanthenone, Pyranothioxanthenone, and Pyranoacridone Ring Systems: A New Class of Cytotoxic Agents.
Authors: Kostakis Ioannis K. , Magiatis Prokopios , Pouli Nicole , Marakos Panagiotis , Skaltsounis Alexios‐Leandros , Pratsinis Harris , Leonce Stephane , Pierre Alain 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Spermine Alkaloids from Albizia adinocephala with Activity Against Plasmodium falciparum Plasmepsin II.
Authors: Ovenden Simon P. B. , Cao Shugeng , Leong Chungyan , Flotow Horst , Gupta Mahabir P. , Buss Antony D. , Butler Mark S. 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Sugar‐Modified Conjugated Diene Analogues of Adenosine and Uridine: Synthesis, Interaction with S‐Adenosyl‐L‐homocysteine Hydrolase, and Antiviral and Cytostatic Effects.
Authors: Wnuk Stanislaw F. , Ro Bong‐Oh , Valdez Carlos A. , Lewandowska Elzbieta , Valdez Neida X. , Sacasa Pablo R. , Yin Dan , Zhang Jinsong , Borchardt Ronald T. , De Clercq Erik 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Cytochalasins Z1, Z2, and Z3, Three 24‐Oxa[14]cytochalasans Produced by Pyrenophora semeniperda.
Authors: Evidente Antonio , Andolfi Anna , Vurro Maurizio , Zonno Maria Chiara , Motta Andrea 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Novel Histone Deacetylase Inhibitors: N‐Hydroxycarboxamides Possessing a Terminal Bicyclic Aryl Group.
Authors: Uesato Shinichi , Kitagawa Manabu , Nagaoka Yasuo , Maeda Taishi , Kuwajima Hiroshi , Yamori Takao 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
CsPb3Bi3Te8 and CsPb4Bi3Te9: Low‐Dimensional Compounds and the Homologous Series CsPbmBi3Te5+m.
Authors: Hsu Kuei‐Fang , Lal Sangeeta , Hogan Tim , Kanatzidis Mercouri G. 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Azapolycyclic Systems via the Intramolecular [4 + 2] Cycloaddition Chemistry of 2‐(Alkylthio)‐5‐amidofurans.
Authors: Padwa Albert , Ginn John D. , Bur Scott K. , Eidell Cheryl K. , Lynch Stephen M. 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of Seven‐Membered Lactones via Nickel‐ and Zinc‐Catalyzed Highly Regio‐ and Stereoselective Cyclization of 2‐Iodobenzyl Alcohols with Propiolates.
Authors: Rayabarapu Dinseh Kumar , Cheng Chien‐Hong 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Microwave‐Assisted Cross‐Coupling Reaction of Sodium Tetraphenylborate with Aroyl Chlorides on Palladium‐Doped KF/Al2O3.
Authors: Wang Jin‐Xian , Yang Yihua , Wei Bangguo , Hu Yulai , Fu Ying 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Coupling Reaction of Azulenyl‐4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolanes with Haloazulenes
Authors: Kurotobi Kei , Tabata Hiroshi , Miyauchi Masato , Murafuji Toshihiro , Sugihara Yoshikazu 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
2,4,6,8‐Tetraiodo‐2,4,6,8‐tetraazabicyclo[3.3.0]octane‐3,7‐dione as a Mild and Convenient Reagent for Iodination of Aromatic Compounds.
Authors: Chaikovski V. K. , Filimonov V. D. , Yagovkin A. Yu. , Ogorodnikov V. D. 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Practical Preparation of 2‐Carboxyphenylboronic Acid and Its Application for the Preparation of Biaryl‐2‐carboxylic Acids Using Suzuki Coupling Reactions.
Authors: Tao Bin , Goel Subhash C. , Singh Jagvir , Boykin David W. 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
9‐Isothiocyanatoanthracene as a Versatile Starting Compound in the Chemistry of Anthracen‐9‐yl Derivatives.
Authors: Janovec Ladislav , Suchar Gejza , Imrich Jan , Kristian Pavol , Sasinkova Vlasta , Alfoldi Juraj , Sedlak Erik 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
New Approach to the Synthesis of 2‐Carbamoylbenzothiazoles.
Authors: Yarovenko V. N. , Stoyanovich F. M. , Zolotarskaya O. Yu. , Chernoburova E. I. , Zavarzin I. V. , Krayushkin M. M. 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
4‐(1‐Benzotriazolyl)‐5‐nitrophthalonitrile as a Highly Active Substrate in Aromatic Nucleophilic Substitution Reactions.
Authors: Smirnov Alexey V. , Abramov Igor G. , Plakhtinskii Vladimir V. , Krasovskaya Galina G. 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
N‐Bridgehead Heterocyclic Compounds Thenoyl‐Substituted. Part 1. Indolizines and Benzoindolizines.
Authors: Georgescu Emilian I. , Georgescu Florentina , Roibu Constantin , Draghici Constantin C. , Caproiu Miron T. 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
1,2,4‐Triazines in Organic Synthesis. Part 17. Tandem Vicarious Nucleophilic Substitution of Hydrogen/Intramolecular Diels—Alder Reaction of 1,2,4‐Triazines into Functionalized Cycloalkenopyridines.
Authors: Branowska Danuta , Ostrowski Stanislaw , Rykowski Andrzej 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
First Synthesis of the Antifungal Oidiolactone C from trans‐Communic Acid: Cytotoxic and Antimicrobial Activity in Podolactone‐Related Compounds.
Authors: Barrero Alejandro F. , Arseniyadis Simeon , Quilez del Moral Jose F. , Herrador M. Mar , Valdivia M. , Jimenez D. 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Syntheses of Novel 4‐tert‐Alkyl Ether Proline‐Based 16‐ and 17‐Membered Macrocyclic Compounds.
Authors: Chen Kevin X. , Njoroge F. George , Vibulbhan Bancha , Buevich Alexei , Chan Tze‐Ming , Girijavallabhan Viyyoor 
Published: May 2010

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Direct Organo‐Catalytic Asymmetric α‐Amination of Aldehydes — A Simple Approach to Optically Active α‐Amino Aldehydes, α‐Amino Alcohols, and α‐Amino Acids.
Authors: Boegevig Anders , Juhl Karsten , Kumaragurubaran Nagaswamy , Zhuang Wei , Joergensen Karl Anker 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Preparation of Cyclic and Bicyclic β‐Amino Acids Derivatives from Methyl 6‐Ethoxy‐5,6‐dihydro‐4H‐1,2‐oxazine‐4‐carboxylate.
Authors: Tishkov Alexander A. , Reissig Hans‐Ulrich , Ioffe Sema L. 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
A Novel Approach to the Synthesis of Amino Sugars. Routes to Selectively Protected 3‐Amino‐3‐deoxy‐aldopentoses Based on Pyridinium Salt Photochemistry.
Authors: Lu Haiyan , Su Zhuoyi , Song Ling , Mariano Patrick S. 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Vitamin D3: Synthesis of seco‐C‐9,11‐bisnor‐17‐Methyl‐1α,25‐dihydroxyvitamin D3 Analogues.
Authors: Wu Yusheng , De Clercq Pierre , Vandewalle Maurits , Bouillon Roger , Verstuyf Annemieke 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Fasciolicidal Activity of 5‐Chloro‐2‐methylthio‐6‐(1‐naphthyloxy)‐1H‐benzimidazole.
Authors: Hernandez‐Campos Alicia , Ibarra‐Velarde Froylan , Vera‐Montenegro Yolanda , Rivera‐Fernandez Norma , Castillo Rafael 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
An Effective Synthesis of N‐Substituted 2‐Sulfenamoylbenzoates and 1,2‐Benzisothiazolin‐3‐ones that Uses 1,2‐Benzisothiazolin‐3‐one as a Leaving Group.
Authors: Shimizu Masao , Sugano Yoshinori , Konakahara Takeo , Gama Yasuo , Shibuya Isao 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis and Biological Activities of N‐(1,2,4‐Triazole‐4‐yl)‐N′‐ (fluorine‐containing‐phenyl)carbamimidothioates.
Authors: Cui Dawei , Li Zhibin , Song Gonghua , Qian Xuhong 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Elemental Iodine Catalyzed [4 + 2] Cycloaddition Reactions of o‐Quinomethanes: An Efficient Synthesis of trans‐Fused Pyrano[3,2‐c]benzopyrans.
Authors: Yadav Jhillu Singh , Reddy Basi V. Subba , Rao C. Venkateswara , Rao K. Vishweshwar 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Applications of Baylis—Hillman Chemistry: One‐Pot Convenient Synthesis of Functionalized (1H)‐Quinol‐2‐ones and Quinolines.
Authors: Basavaiah Deevi , Reddy Ravi Mallikarjuna , Kumaragurubaran Nagaswamy , Sharada Duddu S. 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of 3‐Methoxy‐5‐oxo‐6‐phenyl‐5,6‐dihydro‐4H‐isothiazolo[5,4‐b]‐1,4‐thiazine 7,7‐Dioxide, the First Representative of a New Heterocyclic System.
Authors: Voskoboev N. V. , Gerasyuto A. I. , Zlotin S. G. 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Photocycloaddition of Phthalimide Anion to Alkenes — A Highly Efficient, Convergent Method for [2]Benzazepine Synthesis.
Authors: Suau Rafael , Sanchez‐Sanchez Cristobal , Garcia‐Segura Rafael , Perez‐Inestrosa Ezequiel 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Concise Synthesis of Cyclic Ethers via the Palladium‐Catalyzed Coupling of Ketene Acetal Triflates and Organozinc Reagents. Application to the Iterative Synthesis of Polycyclic Ethers.
Authors: Kadota Isao , Takamura Hiroyoshi , Sato Kumi , Yamamoto Yoshinori 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Inhibition of Cytopathic Effect of Human Immunodeficiency Virus Type‐1 by Various Phorbol Derivatives.
Authors: El‐Mekkawy Sahar , Meselhy Meselhy Ragab , Abdel‐Hafez Atef Abdel‐Monem , Nakamura Norio , Hattori Masao , Kawahata Takuya , Otake Toru 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Synthesis of 2,4‐Diamino‐5‐(fur‐2‐oyl), ‐(thien‐2‐oyl), and ‐(pyrid‐2‐oyl)thiazoles.
Authors: Devi S. K. Chithralekha , Rajasekharan K. N. 
Published: May 2010

AbstractFor Abstract see ChemInform Abstract in Full Text.
Effects of rice straw–derived dissolved organic matter on pyrene sorption by soil
Authors: Zhou Jiangmin , Chen Hualin , Huang Weilin 
Published: May 2010

Abstract
The objectives of the present study were to elucidate the chemical and structural properties of dissolved organic matter (DOM) derived from aerobic decay of rice straw and to quantify the effect of the DOM on the sorption of pyrene on soil. The DOM samples were obtained from microcosms incubated at 0, 21, 63, and 180 d. The bulk DOM samples were fractionated to four fractions: hydrophilic matter (HIM), acid-insoluble matter (AIM), hydrophobic acid (HOA), and hydrophobic neutral (HON) fractions. The bulk DOM and the four DOM fractions were characterized for their elemental compositions and functionalities. The results showed that HIM had the highest H/C atomic ratios, whereas HOA and AIM had the lowest H/C atomic ratios. These DOM samples were used as the background DOMs in the initial aqueous solutions for measuring sorption of pyrene on a paddy soil. The results indicated that, among the four DOM fractions, HOA, HON, and AIM significantly lowered the pyrene sorption coefficients, but HIM had little or no effect on the pyrene sorption by the soil. It appears that less polar AIM and HON had stronger binding affinities for pyrene in water, reducing the sorption coefficient for the soil, whereas more polar and less aromatic HIM had much weaker binding affinity for pyrene in water, causing little or no effect on the pyrene sorption by the soil. The present study showed that rice straw–derived DOM may enhance desorption and transport of organic pollutants in soil–water systems. Environ. Toxicol. Chem. 2010;29:1967–1975. © 2010 SETAC
Relationship between biotic ligand model-based water quality criteria and avoidance and olfactory responses to copper by fish
Authors: Meyer Joseph S. , Adams William J. 
Published: May 2010

Abstract
The U.S. Environmental Protection Agency's (U.S. EPA) water quality criteria for Cu were tested to determine whether they protect fish against neurophysiological impairment. From published studies with rainbow trout (Oncorhynchus mykiss), Chinook salmon (Oncorhynchus tshawytscha), coho salmon (Oncorhynchus kisutch), and fathead minnows (Pimephales promelas), 20% inhibition concentrations (IC20s) were calculated for avoidance of Cu-containing water and for impairment of electroencephalogram (EEG) and electro-olfactogram (EOG) responses to natural odorants in Cu-containing water. Additionally, a Cu-olfactory biotic ligand model (BLM) that fits the coho salmon EOG data was parameterized by changing the sensitivity parameter in the ionoregulatory-based BLM. The IC20s calculated from reported Cu avoidance, EEG, and EOG data and IC20s predicted by the olfactory BLM were compared with acute and chronic Cu criteria calculated using U.S. EPA's BLM 2007 or hardness-adjustment equations. The BLM-based chronic criteria were protective in all 16 exposure water–species combinations used in avoidance and olfaction experiments. Additionally, the BLM-based acute criteria were protective in all 11 exposure water–species combinations in which comparisons could be made with olfactory BLM-predicted IC20s but not in two of the 16 exposure water–species combinations in which comparisons could be made with the reported IC20s (which were ≤8% lower than but did not differ significantly from the BLM-based acute criteria; p &gt; 0.05). In effect, the olfactory BLM factored out the relatively high variability in the reported IC20s. It is concluded that the U.S. EPA's BLM-based water quality criteria for Cu protect against these types of neurophysiological impairment in the six species–endpoint combinations analyzed in this paper. However, the U.S. EPA's hardness-based criteria for Cu sometimes were considerably underprotective and sometimes were much less protective than the BLM-based criteria. Environ. Toxicol. Chem. 2010;29:2096–2103. © 2010 SETAC
Perfluorooctane sulfonate toxicity, isomer-specific accumulation, and maternal transfer in zebrafish (Danio rerio) and rainbow trout (Oncorhynchus mykiss)
Authors: Sharpe Rainie L. , Benskin Jonathan P. , Laarman Anne H. , MacLeod Sherri L. , Martin Jonathan W. , Wong Charles S. , Goss Greg G. 
Published: May 2010

Abstract
Perfluorooctane sulfonate (PFOS; C8F17SO 3−) bioaccumulation and toxicity have been demonstrated in both aquatic and terrestrial organisms. The majority of investigations have examined total PFOS concentrations in wildlife and in toxicity testing, but isomer-specific monitoring studies are less common, and no laboratory-based study of PFOS isomer accumulation in fish has been reported. The present study examined accumulation and maternal transfer of PFOS isomers in zebrafish and tissue-specific accumulation of PFOS isomers in trout parr. A median lethal dose (LC50) of 22.2 and 2.5 mg/L was calculated for adult zebrafish and trout parr, respectively. A two-week PFOS exposure resulted in tissue-specific PFOS accumulation in trout, with maximum concentrations identified in the liver tissue (&gt;50 µg/g). Prior exposure to PFOS as alevin did not affect the accumulation of PFOS in tissues later in life. In both species, accumulation of branched PFOS isomers generally occurred to a lesser extent than linear PFOS, which may explain the relative deficiency of branched PFOS isomers in some aquatic species in the field. Analysis of exposed trout tissues indicated that isomer discrimination may occur at the level of elimination or uptake and elimination processes in the kidney or gill, respectively. When zebrafish underwent a reproductive cycle in the presence of PFOS, approximately 10% (wt) of the adult PFOS body burden was transferred to the developing embryos, resulting in a higher total PFOS concentration in eggs (116 ± 13.3 µg/g) than in the parent fish (72.1 ± 7.6 µg/g). The isomer profile in eggs was not significantly different from that of adults, suggesting that the maternal transfer of branched and linear PFOS isomers in fish is largely nonisomer specific. Environ. Toxicol. Chem. 2010;29:1957–1966. © 2010 SETAC
A new multilevel algebraic preconditioner for the diffusion equation in heterogeneous media
Authors: Kuznetsov Yu , Prokopenko A. 
Published: May 2010

AbstractWe develop and analyze a new multilevel preconditioner for algebraic systems arising from the finite volume discretization of 3D diffusion–reaction problems in highly heterogeneous media. The system matrices are assumed to be symmetric M‐matrices. The preconditioner is based on a special coarsening algorithm and the inner Chebyshev iterative procedure. The condition number of the preconditioned matrix does not depend on the coefficients in the diffusion operator. Numerical experiments confirm theoretical results and reveal the competitiveness of the new preconditioner with respect to a well‐known algebraic multigrid preconditioner. Copyright © 2010 John Wiley & Sons, Ltd.
Using ellipsometry for the evaluation of surface damage and sputtering yield in organic films with irradiation of argon cluster ion beams
Authors: Hada Masaki , Ninomiya Satoshi , Seki Toshio , Aoki Takaaki , Matsuo Jiro 
Published: May 2010

AbstractThe film thickness and surface damage layer of vapor‐deposited L‐leucine amino acid films irradiated with Ar cluster ion beams were characterized by PSCRA ellipsometry. The damaged layer on the surface of the L‐leucine film irradiated with Ar cluster ion beam was quite thin, less than 1 nm in thickness. In contrast, films irradiated with Ar monomer ion beam have changed into totally different films. The ellipsometry method also allowed accurate measurements of the sputtering yield from the L‐leucine film irradiated with Ar cluster ion beams at nm‐order resolution. These results suggested that with proper analysis, the optical method of ellipsometry enables estimation of the surface damage layer and measurement of sputtering yield of organic films irradiated with cluster ion beams. Copyright © 2010 John Wiley & Sons, Ltd.
Surface analysis of polyvinyl chloride bombarded by Ar+ and charged water droplets
Authors: Hiraoka Kenzo , Iijima Yoshitoki , Sakai Yuji 
Published: May 2010

AbstractA comparative study of 500 eV Ar+ ion impact and the electrospray droplet impact (EDI) applied to polyvinyl chloride (PVC) was made. In EDI, the charged electrospray water droplets are introduced in vacuum, accelerated and allowed to impact the sample. The samples, after etching by Ar+ and EDI, were examined by XPS. While chlorine is selectively etched by Ar+ ion impact, the XPS spectra did not change with prolonged charged water droplets irradiation, i.e. EDI is capable of surface etching with little damage of the sample after irradiation. Copyright © 2010 John Wiley & Sons, Ltd.
Development of an energy‐resolved method for SIMS in‐depth analysis of metal–polymer interfaces
Authors: Téllez Helena , Vadillo José M. , Laserna J. Javier 
Published: May 2010

AbstractEnergy‐resolved SIMS depth profiling has been succesfully applied in the analysis of Al‐metalized polypropylene films used in the capacitor industry. The accurate identification of the metal–polymer interface was not straightforward due to the simultaneous contribution of isobaric ions coming from each layer (27Al+/43AlO+ ions from the aluminium layer and 27C2H3+/43C3H7+ from the polymer substrate). Kinetic energy filtering by means of a 45° electrostatic analyzer (ESA) has allowed the resolution of the metal‐polymer interface by selecting a suitable kinetic energy corresponding to the ions generated in the metallized layer but not on the polymer. Owing to the dielectric polymeric substrate, charge effects might be produced during depth profiling. These charge buildup effects are minimized by flooding the surface with low‐energy electrons (500 eV) and a specific sample‐mounting procedure assuring grounded conditions. The excellent repeatability and sensibility of the technique allows studying the degradative process in the capacitor films and the accurate location of the metal–polymer interface, and therefore, the nanometric metal thickness variations. These factors drastically affect the capacitor's performance and they will determine the potential failures that could be developed during the capacitor's life cycle. Copyright © 2010 John Wiley & Sons, Ltd.
Online-Datenbanken und systematische Metaanalysen komplex-genetischer Erkrankungen
Authors: Lill C.M. , Bertram L. 
Published: May 2010

Zusammenfassung
Die Suszeptibilität komplex-genetischer Erkrankungen wird durch eine unbekannte Anzahl genetischer Faktoren bestimmt. In den letzten Jahrzehnten sind Hunderte von Suszeptibilitätsloci für die Alzheimer-Krankheit (AD), das idiopathische Parkinson-Syndrom (PD), Schizophrenie (SZ) und multiple Sklerose (MS) beschrieben worden. Diese schwierig zu überschauende Datenlage für jede dieser Erkrankungen wird kompliziert durch die ansteigende Zahl genomweiter Assoziationsstudien. Um die Evaluation und Interpretation der Ergebnisse zu erleichtern, haben wir Internet-Datenbanken für genetische Assoziationsstudien in AD, PD, SZ und MS generiert. Neben einer detailierten Synopse aller verfügbaren Studien bieten die Datenbanken allel-basierte Metaanalysen der Polymorphismen, zu denen ausreichende Daten vorliegen. In diesem Review stellen wir anhand der Datenbanken für AD (AlzGene) und PD (PDGene) den Hintergrund und die Implikationen dieses Ansatzes vor.
Kinder aus suchtbelasteten Familien
Authors: Moesgen Diana , Klein Michael 
Published: May 2010

Einleitung
In Deutschland sind epidemiologischen Studien zufolge 2,65 Millionen Kinder von Eltern mit einer alkoholbezogenen Störung und weitere etwa 60.000 Kinder von opiatabhängigen Eltern betroffen. Diese Kinder sind einer Vielzahl an Risikofaktoren ausgesetzt, die eine psychopathogene Entwicklung begünstigen können. Dennoch existieren auch protektive Faktoren, die in der praktischen Arbeit mit Kindern gefördert werden sollen. Bislang sind jedoch kaum standardisierte und evaluierte Programme für betroffene Kinder vorhanden.