bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of single chain antibodies to breast cancer stem cells using phage display
Authors: Gur Deniz , Liu Suling , Shukla Anurag , Pero Stephanie C. , Wicha Max S , Krag David N 
Published: November 2009

AbstractRecent evidence suggests that most malignancies are driven by “cancer stem cells” sharing the signature characteristics of adult stem cells: the ability to self renew and to differentiate. Furthermore these cells are thought to be quiescent, infrequently dividing cells with a natural resistance to chemotherapeutic agents. These studies theorize that therapies, which effectively treat the majority of tumor cells but ‘miss’ the stem cell population, will fail, while therapies directed at stern cells can potentially eradicate tumors. In breast cancer, researchers have isolated ‘breast cancer stem cells’ capable of recreating the tumor in vivo and in vitro. Generated new tumors contained both additional numbers of cancer stem cells and diverse mixed populations of cells present in the initial tumor, supporting the intriguing self‐renewal and differentiation characteristics. In the present study, an antibody phage library has been used to search for phage displayed‐single chain antibodies (scFv) with selective affinity to specific targets on breast cancer stem cells. We demonstrate evidence of two clones binding specifically to a cancer stem cell population isolated from the SUMl59 breast cancer cell line. These clones had selective affinity for cancer stem cells and they were able to select cancer stem cells among a large population of non‐stem cancer cells in paraffin‐embedded sections. The applicability of these clones to paraffin sections and frozen tissue specimens made them good candidates to be used as diagnostic and prognostic markers in breast cancer patient samples taking into consideration the cancer stern cell concept in tumor biology. © 2009 American Institute of Chemical Engineers Biotechnol. Prog., 2009
In situ near infrared spectroscopy for analyte‐specific monitoring of glucose and ammonium in streptomyces coelicolor fermentations
Authors: Petersen Nanna , Ödman Peter , Padrell Albert E. Cervera , Stocks Stuart , Lantz Anna Eliasson , Gernaey Krist V. 
Published: November 2009

AbstractThere are many challenges associated with in situ collection of near infrared (NIR) spectra in a fermentation broth, particularly for highly aerated and agitated fermentations with filamentous organisms. In this study, antibiotic fermentation by the filamentous bacterium Streptomyces coelicolor was used as a model process. Partial least squares (PLS) regression models were calibrated for glucose and ammonium based on NIR spectra collected in situ. To ensure that the models were calibrated based on analyte‐specific information, semisynthetic samples were used for model calibration in addition to data from standard batches. Thereby, part of the inherent correlation between the analytes could be eliminated. The set of semisynthetic samples were generated from fermentation broth from five separate fermentations to which different amounts of glucose, ammonium, and biomass were added. This method has previously been used off line but never before in situ. The use of semisynthetic samples along with validation on an independent batch provided a critical and realistic evaluation of analyte‐specific models based on in situ NIR spectroscopy. The prediction of glucose was highly satisfactory resulting in a RMSEP of 1.1 g/L. The prediction of ammonium based on NIR spectra collected in situ was not satisfactory. A comparison with models calibrated based on NIR spectra collected off line suggested that this is caused by signal attenuation in the optical fibers in the region above 2,000 nm; a region which contains important absorption bands for ammonium. For improved predictions of ammonium in situ, it is suggested to focus efforts on enhancing the signal in that particular region. © 2009 American Institute of Chemical Engineers Biotechnol. Prog., 2010
Multifrequency permittivity measurements enable on‐line monitoring of changes in intracellular conductivity due to nutrient limitations during batch cultivations of CHO cells
Authors: Ansorge Sven , Esteban Geoffrey , Schmid Georg 
Published: November 2009

AbstractLab and pilot scale batch cultivations of a CHO K1/dhfr− host cell line were conducted to evaluate on‐line multifrequency permittivity measurements as a process monitoring tool. The β‐dispersion parameters such as the characteristic frequency (fC) and the permittivity increment (Δεmax) were calculated on‐line from the permittivity spectra. The dual‐frequency permittivity signal correlated well with the off‐line measured biovolume and the viable cell density. A significant drop in permittivity was monitored at the transition from exponential growth to a phase with reduced growth rate. Although not reflected in off‐line biovolume measurements, this decrease coincided with a drop in OUR and was probably caused by the depletion of glutamine and a metabolic shift occurring at the same time. Sudden changes in cell density, cell size, viability, capacitance per membrane area (CM), and effects caused by medium conductivity (σm) could be excluded as reasons for the decrease in permittivity. After analysis of the process data, a drop in fC as a result of a fall in intracellular conductivity (σi) was identified as responsible for the observed changes in the dual‐frequency permittivity signal. It is hypothesized that the β‐dispersion parameter fC is indicative of changes in nutrient availability that have an impact on intracellular conductivity σi. On‐line permittivity measurements consequently not only reflect the biovolume but also the physiological state of mammalian cell cultures. These findings should pave the way for a better understanding of the intracellular state of cells and render permittivity measurements an important tool in process development and control. © 2009 American Institute of Chemical Engineers Biotechnol. Prog., 2010
Exploring the Substrate Promiscuity of Drug‐Modifying Enzymes for the Chemoenzymatic Generation of N‐Acylated Aminoglycosides
Authors: Green Keith D. , Chen Wenjing , Houghton Jacob L. , Fridman Micha , Garneau‐Tsodikova Sylvie 
Published: November 2009

AbstractAminoglycosides are broad‐spectrum antibiotics commonly used for the treatment of serious bacterial infections. Decades of clinical use have led to the widespread emergence of bacterial resistance to this family of drugs limiting their efficacy in the clinic. Here, we report the development of a methodology that utilizes aminoglycoside acetyltransferases (AACs) and unnatural acyl coenzyme A analogues for the chemoenzymatic generation of N‐acylated aminoglycoside analogues. Generation of N‐acylated aminoglycosides is followed by a simple qualitative test to assess their potency as potential antibacterials. The studied AACs (AAC(6′)‐APH(2′′) and AAC(3)‐IV) show diverse substrate promiscuity towards a variety of aminoglycosides as well as acyl coenzyme A derivatives. The enzymes were also used for the sequential generation of homo‐ and hetero‐di‐N‐acylated aminoglycosides. Following the clinical success of the N‐acylated amikacin and arbekacin, our chemoenzymatic approach offers access to regioselectively N‐acylated aminoglycosides in quantities that allow testing of the antibacterial potential of the synthetic analogues making it possible to decide which molecules will be worth synthesizing on a larger scale.
ChemInform Abstract: Complex Interrupted Tetrahedral Frameworks in the Nitridosilicates M7Si6N25 (M: La, Ce, Pr).
Authors: Schmolke Christian , Oeckler Oliver , Bichler Daniel , Johrendt Dirk , Schnick Wolfgang 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis Temperature Effect on the Structural Features and Optical Absorption of Zn1‐xCoxAl2O4 Oxides.
Authors: Gaudon M. , Apheceixborde A. , Menetrier M. , Le Nestour A. , Demourgues A. 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: One‐Step Synthesis of White‐Light‐Emitting Quantum Dots at Low Temperature.
Authors: Shen Chien‐Chih , Tseng Wei‐Lung 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reinvestigation of the Fe‐Rich Part of the Pseudo‐Binary System SrO—Fe2O3.
Authors: Langhof N. , Seifert D. , Goebbels M. , Toepfer J. 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Modeling Dinitrogen Activation by Lithium: A Mechanistic Investigation of the Cleavage of N2 by Stepwise Insertion into Small Lithium Clusters.
Authors: Roy Debjani , Navarro‐Vazquez Armando , von Rague Schleyer Paul 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Template‐Free Hydrothermal Synthesis and Photocatalytic Performances of Novel Bi2SiO5 Nanosheets.
Authors: Chen Ruigen , Bi Jinhong , Wu Ling , Wang Wanjun , Li Zhaohui , Fu Xianzhi 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: BaLn2Se4 (Ln: Er, Tm and Yb).
Authors: Bugaris Daniel E. , Ibers James A. 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Unique Charge Ordering of Manganese in a New Mixed Valent Phosphate K3Mn3IIMnIII(PO4) (H0.5PO4)2(HPO4)2.
Authors: Adam L. , Guesdon A. , Raveau B. 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stoichiometric CeCuOS — A Well‐Behaved Ce(III) Layered Oxysulfide.
Authors: Pitcher Michael J. , Smura Catherine F. , Clarke Simon J. 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Strontium—Copper Selenite—Chlorides: Synthesis and Structural Investigation.
Authors: Berdonosov Peter S. , Olenev Andrei V. , Dolgikh Valery A. 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Helices, Chirality and Interpenetration: The Versatility and Remarkable Interconversion of Silver—Copper Cyanide Frameworks.
Authors: Chippindale Ann M. , Hibble Simon J. 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Amino Thiols versus Amino Alcohols in the Asymmetric Alkynylzinc Addition to Aldehydes.
Authors: Subirats Silvia , Jimeno Ciril , Pericas Miquel A. 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Enantioselective Michael Addition of Malonate Derivatives to Enones Catalyzed by an N,N′‐Dioxide—Scandium(III) Complex.
Authors: Chen Donghui , Chen Zhenling , Xiao Xiao , Yang Zhigang , Lin Lili , Liu Xiaohua , Feng Xiaoming 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Chiral Auxiliary N‐1‐(1′‐Naphthyl)ethyl‐O‐tert butylhydroxylamine: A Chiral Weinreb Amide Equivalent.
Authors: Chernega Alexander N. , Davies Stephen G. , Goodwin Christopher J. , Hepworth David , Kurosawa Wataru , Roberts Paul M. , Thomson James E. 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: NO Cations as Highly Efficient Catalysts for Carbon—Carbon Bond Forming Reactions.
Authors: Yamashita Yasuhiro , Kobayashi Shu 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Gold‐Catalyzed Cycloaromatization of 2,4‐Dien‐6‐yne Carboxylic Acids: Synthesis of 2,3‐Disubstituted Phenols and Unsymmetrical Bi‐ and Terphenyls.
Authors: Garcia‐Garcia Patricia , Fernandez‐Rodriguez Manuel A. , Aguilar Enrique 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient Reoxidation of Palladium by a Hybrid Catalyst in Aerobic Palladium‐Catalyzed Carbocyclization of Enallenes.
Authors: Johnston Eric V. , Karlsson Erik A. , Lindberg Staffan A. , Aakermark Bjoern , Baeckvall Jan‐E. 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Active New Chiral Co(II) Salen Catalysts Immobilized by Electrostatic Interaction with Sulfonic Acid Linkages on Ordered Mesoporous SBA‐16 Silica.
Authors: Kim Yong‐Suk , Guo Xiao‐Feng , Kim Geon‐Joong 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Polyethylene Glycol Radical‐Initiated Oxidation of Benzylic Alcohols in Compressed Carbon Dioxide
Authors: Wang Jin‐Quan , He Liang‐Nian , Miao Cheng‐Xia 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: IBS‐Catalyzed Oxidative Rearrangement of Tertiary Allylic Alcohols to Enones with Oxone.
Authors: Uyanik Muhammet , Fukatsu Ryota , Ishihara Kazuaki 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Oxidative C—C Bond Formation (Scholl Reaction) with DDQ as an Efficient and Easily Recyclable Oxidant.
Authors: Zhai Linyi , Shukla Ruchi , Rathore Rajendra 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Microwave‐Assisted Trans‐Halogenation Reactions of Various Chloro‐, Bromo‐, Trifluoromethanesulfonyloxy‐ and Nonafluorobutanesulfonyloxy‐Substituted Quinolines, Isoquinolines and Pyridines Leading to the Corresponding Iodinated Heterocycles.
Authors: Bissember Alex C. , Banwell Martin G. 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electron‐Transfer Photoredox Catalysis: Development of a Tin‐Free Reductive Dehalogenation Reaction.
Authors: Narayanam Jagan M. R. , Tucker Joseph W. , Stephenson Corey R. J. 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Addition of Thioacetic Acid to Nitroalkenes via N‐Sulfinyl Urea Organocatalysis.
Authors: Kimmel Kyle L. , Robak MaryAnn T. , Ellman Jonathan A. 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mukaiyama Aldol Reaction Catalyzed by Mesoporous Aluminosilicate.
Authors: Ito Suguru , Yamaguchi Hitoshi , Kubota Yoshihiro , Asami Masatoshi 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Novel One‐Pot Three‐(in situ Five)‐Component Condensation Reaction: An Unexpected Approach for the Synthesis of Tetrahydro‐2,4‐dioxo‐1H‐benzo[b][1,5]diazepine‐3‐yl‐2‐methylpropanamide Derivatives.
Authors: Shaabani Ahmad , Rezayan Ali Hossein , Keshipour Sajjad , Sarvary Afshin , Ng Seik Weng 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Substitution of Both Chloro and Sulfinyl Groups of Aryl 1‐Chlorocyclopropyl Sulfoxides in One Pot via Cyclopropylmagnesium Carbenoids: A Synthesis of Multi‐Substituted Cyclopropanes.
Authors: Yajima Masanobu , Nonaka Ryo , Yamashita Hironori , Satoh Tsuyoshi 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Broensted Base/Lewis Acid Cooperative Catalysis in the Enantioselective Conia‐Ene Reaction.
Authors: Yang Ting , Ferrali Alessandro , Sladojevich Filippo , Campbell Leonie , Dixon Darren J. 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cobalt‐Catalyzed 1,4‐Hydrovinylation of Styrenes and 1‐Aryl‐1,3‐butadienes.
Authors: Hilt Gerhard , Danz Michael , Treutwein Jonas 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Acid‐Catalyzed Skeletal Rearrangement of Epoxy Alkynes: A Fast Access to Highly Functionalized Allenes.
Authors: Zheng Zhao‐Jing , Shu Xing‐Zhong , Ji Ke‐Gong , Zhao Shu‐Chun , Liang Yong‐Min 
Published: November 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.