bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Vivo Assessment of Astrocyte Reactivity in Patients with Progressive Supranuclear Palsy
Authors: Hirata Kosei , Matsuoka Kiwamu , Tagai Kenji , Endo Hironobu , Tatebe Harutsugu , Ono Maiko , Kokubo Naomi , Kataoka Yuko , Oyama Asaka , Shinotoh Hitoshi , Takahata Keisuke , Obata Takayuki , Dehghani Masoumeh , Near Jamie , Kawamura Kazunori , Zhang Ming‐Rong , Shimada Hitoshi , Shimizu Hiroshi , Kakita Akiyoshi , Yokota Takanori , Tokuda Takahiko , Higuchi Makoto , Takado Yuhei 
Published: May 2024

ObjectiveAlthough astrocytic pathology is a pathological hallmark of progressive supranuclear palsy (PSP), its pathophysiological role remains unclear. This study aimed to assess astrocyte reactivity in vivo in patients with PSP. Furthermore, we investigated alterations in brain lactate levels and their relationship with astrocyte reactivity.MethodsWe included 30 patients with PSP‐Richardson syndrome and 30 healthy controls; in patients, tau deposition was confirmed through 18F‐florzolotau positron emission tomography. Myo‐inositol, an astroglial marker, and lactate were quantified in the anterior cingulate cortex through magnetic resonance spectroscopy. We measured plasma biomarkers, including glial fibrillary acidic protein as another astrocytic marker. The anterior cingulate cortex was histologically assessed in postmortem samples of another 3 patients with PSP with comparable disease durations.ResultsThe levels of myo‐inositol and plasma glial fibrillary acidic protein were significantly higher in patients than those in healthy controls (p < 0.05); these increases were significantly associated with PSP rating scale and cognitive function scores (p < 0.05). The lactate level was high in patients, and correlated significantly with high myo‐inositol levels. Histological analysis of the anterior cingulate cortex in patients revealed reactive astrocytes, despite mild tau deposition, and no marked synaptic loss.InterpretationWe discovered high levels of astrocyte biomarkers in patients with PSP, suggesting astrocyte reactivity. The association between myo‐inositol and lactate levels suggests a link between reactive astrocytes and brain energy metabolism changes. Our results indicate that astrocyte reactivity in the anterior cingulate cortex precedes pronounced tau pathology and neurodegenerative processes in that region, and affects brain function in PSP. ANN NEUROL 2024;96:247–261
New Lead‐free Hybrid Layered Double Perovskite Halides: Synthesis, Structural Transition and Ultralow Thermal Conductivity
Authors: Mandal Arnab , Goswami Sayan , Das Subarna , Swain Diptikanta , Biswas Kanishka 
Published: May 2024

AbstractHybrid layered double perovskites (HLDPs), representing the two‐dimensional manifestation of halide double perovskites, have elicited considerable interest owing to their intricate chemical bonding hierarchy and structural diversity. This intensified interest stems from the diverse options available for selecting alternating octahedral coordinated trivalent [M(III)] and monovalent metal centers [M(I)], along with the distinctive nature of the cationic organic amine located between the layers. Here, we have synthesized three new compounds with general formula (R′/R′′)4/2M(III)M(I)Cl8; where R′=C3H7NH3 (i.e. 3N) and R′′=NH3C4H8NH3 (i.e. 4N4); M(III)=In3+ or Ru3+; M(I)=Cu+ by simple solution‐based acid precipitation method. The structural analysis reveals that (4N4)2CuInCl8 and (4N4)2CuRuCl8 adopt the layered Dion Jacobson (DJ) structure, whereas (3N)4CuInCl8 exhibits layered Ruddlesden Popper (RP) structure. The alternative octahedra within the inorganic layer display distortions and tilting. Three compounds show temperature‐dependent structural phase transitions where changes in the staking of inorganic layer, extent of octahedral tilting and reorientation of organic spacers with temperature have been noticed. We have achieved ultralow lattice thermal conductivity (κL) in the HLDPs in the 2 to 300 K range, marking a distinctive feature within the realm of HLDP systems. The RP‐HLDP compound, (3N)4CuInCl8, demonstrates anisotropy in κL while measured parallel and perpendicular to layer stacking, showcasing ultralow κL of 0.15 Wm−1K−1 at room temperature, which is one of the lowest values obtained among Pb‐free metal halide perovskite. The observed ultralow κL in three new HLDPs is attributed to significant lattice anharmonicity arising from the chemical bonding heterogeneity and soft crystal structure, which resulted in low‐energy localized optical phonon modes that suppress heat‐carrying acoustic phonons.
A Strained Donor‐Acceptor Carbon Nanohoop: Synthesis, Photophysical and Charge Transport Properties
Authors: Fang Pengwei , Cheng Zaitian , Peng Wei , Xu Jixian , Zhang Xinyu , Zhang Fapei , Zhuang Guilin , Du Pingwu 
Published: May 2024

AbstractHerein, we report the synthesis of a novel intramolecular donor‐acceptor (D−A) system ([12]CPP‐8TPAOMe) based on cycloparaphenylenes (CPPs) grafted with eight di(4‐methoxyphenyl)amino groups (TPAOMe) as donors. Compared to [12]CPP, D−A nanohoop exhibited significant changes in physical properties, including a large redshift (>78 nm) in the fluorescence spectrum and novel positive solvatofluorochromic properties with a maximum peak ranging from 484 nm to 546 nm. The potential applications of [12]CPP‐8TPAOMe in electron‐ and hole‐transport devices were further investigated, and its bipolar behavior as a charge transport active layer was clearly observed.
Controlling the Orientation‐Dependent Second Harmonic Generation in Hybrid Germanium Perovskites
Authors: Guo Zhu , Han Dingchong , Liu Huan , Hu Yaoqiao , Zhang Weixiong , Chen Rui , Mao Lingling 
Published: May 2024

AbstractManipulating the crystal orientation plays a crucial role in the conversion efficiency during second harmonic generation (SHG). Here, we provide a new strategy in controlling the surface‐dependent anisotropic SHG with the precise design of (101) and (2
0) MAGeI3 facets. Based on the SHG measurement, the (101) MAGeI3 single crystal exhibits larger SHG (1.3×(2
0) MAGeI3). Kelvin probe force microscopy imaging shows a smaller work function for the (101) MAGeI3 compared with the (2
0), which indirectly demonstrates the stronger intrinsic polarization on the (101) surface. X‐ray photoelectron spectroscopy confirms the band bending within the (101) facet. Temperature‐dependent steady‐state and time‐resolved photoluminescence spectroscopy show shorter lifetime and wider emission band in the (101) MAGeI3 single crystal, revealing the higher defect states. Additionally, powder X‐ray diffraction patterns show the (101) MAGeI3 possesses larger in‐plane polar units [GeI3]− density, which could directly enhance the spontaneous polarization in the (101) facet. Density functional theory (DFT) calculation further demonstrates the higher intrinsic polarization in the (101) facet compared with the (2
0) facet, and the larger built‐in electric field in the (101) facet facilitates surface vacancy defect accumulation. Our work provides a new angle in tuning and optimizing hybrid perovskite‐based nonlinear optical materials.
Triphenylamine[3]arenes: Streamlining Synthesis of a Versatile Macrocyclic Platform for Supramolecular Architectures and Functionalities
Authors: Fang Wangjian , Zhang Jianyu , Guo Minjie , Zhao Yanli , Sue Andrew C.‐H. 
Published: May 2024

AbstractTriphenylamine[3]arenes (TPA[3]s), featuring [16]paracyclophane backbone with alternating carbon and nitrogen bridging atoms, were synthesized through a BF3 ⋅ Et2O‐catalyzed cyclization reaction using triphenylamine derivatized monomers and paraformaldehyde. This molecular design yielded a series of TPA[3] macrocycles with high efficiency, with their facile derivatizations also successfully demonstrated. On account of the strong electron‐donating properties of the TPA moieties, these TPA[3]s exhibit remarkable delayed fluorescence, and possess a significant affinity for iodine. Furthermore, their inherent three‐fold symmetry rendered TPA[3]s as novel building blocks for the construction of extended frameworks and molecular cages. This advancement expands the versatility of discrete macrocycles into complex architectures, enhancing their applicability across a broad spectrum of applications.
Boron‐Induced Interstitial Effects Drive Water Oxidation on Ordered Ir−B Compounds
Authors: Chen Ding , Yu Ruohan , Zhao Hongyu , Jiao Jixiang , Mu Xueqin , Yu Jun , Mu Shichun 
Published: May 2024

AbstractInterstitial filling of light atoms strongly affects the electronic structure and adsorption properties of the parent catalyst due to ligand and ensemble effects. Different from the conventional doping and surface modification, constructing ordered intermetallic structures is more promising to overcome the dissolution and reconstruction of active sites through strong interactions generated by atomic periodic arrangement, achieving joint improvement in catalytic activity and stability. However, for tightly arranged metal lattices, such as iridium (Ir), obtaining ordered filling atoms and further unveiling their interstitial effects are still limited by highly activated processes. Herein, we report a high‐temperature molten salt assisted strategy to form the intermetallic Ir−B compounds (IrB1.1) with ordered filling by light boron (B) atoms. The B residing in the interstitial lattice of Ir constitutes favorable adsorption surfaces through a donor‐acceptor architecture, which has an optimal free energy uphill in rate‐determining step (RDS) of oxygen evolution reaction (OER), resulting in enhanced activity. Meanwhile, the strong coupling of Ir−B structural units suppresses the demetallation and reconstruction behavior of Ir, ensuring catalytic stability. Such B‐induced interstitial effects endow IrB1.1 with higher OER performance than commercial IrO2, which is further validated in proton exchange membrane water electrolyzers (PEMWEs).
Preparation and indoor virulence determination of a temperature‐sensitive insecticide against Zeugodacus cucurbitae (Coquillett)
Authors: Wang Aqiang , Ni Chengcheng , Peng Sihua , Yang Shuyan , Wu Qianxing , Zhou Shihao 
Published: May 2024

AbstractZeugodacus cucurbitae (Coquillett) is an important fruit and vegetable pest, especially in high‐temperature seasons. In our previous research, we developed a temperature‐sensitive sustained‐release attractant for Z. cucurbitae, that not only can control the release rate of cuelure according to the temperature change, but also shows an excellent trapping effect on Z. cucurbitae. To further enhance the killing effect of the temperature‐sensitive attractant on Z. cucurbitae, this study proposed using it in combination with an insecticide to prepare a temperature‐sensitive insecticide for Z. cucurbitae. Based on the controlled release technology of pesticides, a temperature‐sensitive Z. cucurbitae insecticide was developed by using PNIPAM gel as a temperature‐sensitive switch to carry both cuelure and insecticide at the same time. In addition, the lethal effect of different pesticides on Z. cucurbitae were tested by indoor toxicity test, and the best pesticide combination was screened out. The temperature‐sensitive insecticide prepared in this study not only had excellent thermal response and controlled release ability, but also enhanced its toxicological effects on Z. cucurbitae because it contained insecticides. Among them, combining thiamethoxam and clothianidin with the temperature‐sensitive attractants was the most effective, and their lethality reached more than 97% against Z. cucurbitae. This study is not only of great practical significance for the monitoring and controlling Z. cucurbitae, but also provides theoretical basis and reference value for the combination of temperature‐sensitive attractant and insecticide.
Synthesis and biological studies of pyrimidine derivatives targeting metabolic enzymes
Authors: Korkusuz Elif , Sert Yusuf , Arslan Seher , Aydın Hava , Yıldırım İsmail , Demir Yeliz , Gülçin İlhami , Koca İrfan 
Published: May 2024

AbstractNovel synthesized pyrimidine derivatives were investigated against carbonic anhydrase isoenzymes I and II (hCA I and II), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), α‐glycosidase, and aldose reductase (AR) enzymes associated with some common diseases such as epilepsy, glaucoma, Alzheimer's disease, diabetes, and neuropathy. When the results were examined, novel synthesized pyrimidine derivatives were found to have effective inhibition abilities toward the metabolic enzymes. IC50 values and Ki values were calculated for each pyrimidine derivative and compared to positive controls. The synthesized novel pyrimidine derivatives exhibited Ki values in the range of 39.16 ± 7.70–144.62 ± 26.98 nM against hCA I, 18.21 ± 3.66–136.35 ± 21.48 nM toward hCA II, which is associated with different pathological and physiological processes, 33.15 ± 4.85–52.98 ± 19.86 nM on AChE, and 31.96 ± 8.24–69.57 ± 21.27 nM on BChE. Also, Ki values were determined in the range of 17.37 ± 1.11–253.88 ± 39.91 nM against α‐glycosidase and 648.82 ± 53.74–1902.58 ± 98.90 nM toward AR enzymes. Within the scope of the study, the inhibition types of the novel synthesized pyrimidine derivatives were evaluated.
Mixed N,O‐donor Directed Blue Emissive Nano‐dispersed Mesoporous Mn(II)‐MOF: Dual Sensing Probe for Recyclable and Ultrasensitive ppb‐Level Recognition of TNP and Cr(VI)‐Oxoanions
Authors: Mondal Udayan , Raksha Kumari , Mondal Priyantan , Banerjee Priyabrata 
Published: May 2024

AbstractA new mesoporous Mn(II)‐MOF [Mn2(phen)2(nia)2]∞ with 4‐c uninodal net topology and reiterating rectangular channels in its cargo‐net like extension was synthesized using π‐conjugated phenanthroline (phen) and syn‐syn bridging 5‐nitroisopthalic acid (nia) linkers. The MOF (1) exhibited phase purity, uniform morphology, photo and thermal stability, and robustness; duly triggered by the exceptional framework rigidity via intermolecular H‐bonding and interlayer π–π stacking interactions. The bright‐blue luminescence of the MOF nano‐dispersion was explored for sensitive, specific and ultrafast detection of trinitrophenol (TNP) with extremely low LOD (90.62 nM), high KSV (18.27×104 M−1) and Kq (4×1014 M−1s−1). The vapor‐phase TNP sensing was also accomplished. Additionally, 1 served towards discriminatory, aqueous‐phase monitoring of Cr(VI)‐oxoanions, depicting LODs: 36.08 and 35.70 ppb; KSV: 3.46×104 and 4.87×104 M−1; Kq: 3.26×1013 M−1s−1 and 4.31×1013 M−1s−1; and response time: 32 and 40s for CrO42− and Cr2O72− respectively. The quenching mechanisms (i. e., RET, PET, IFE, weak interactions, collisional quenching and π⋅⋅⋅π stacking) was explained from several experimental investigations and theoretical DFT calculations. The recyclable sensing events and quantification from complex environmental matrices with admirable recovery rates and high KSV (13.02–22.44×104; ~6.31–10.98×104 and ~6.60–11.42×104 M−1 for TNP, CrO42− and Cr2O72−) undoubtedly advocated the consistency of the probe.
Categorizing and identifying preferred interests in autistic toddlers
Authors: Frisch MaryKate , Coulter Kirsty L. , Thomas Rebecca P. , Barton Marianne L. , Robins Diana L. , Fein Deborah A. 
Published: May 2024

AbstractPreferred interests are characteristic of autism spectrum disorder and are reported by parents starting at an early age. However, limited research has explored the presentation of preferred interests in toddlerhood. Previous literature suggests that both the intensity and type of preferred interests held by autistic individuals differ from those held by peers with developmental delay and no diagnosis and that autistic interests are more unusual in nature. While preferred interests are seen in typical child development, previous research suggests that the presence of preferred interests in children with no diagnosis declines with age. Literature also indicates that the sex and cognitive ability of autistic children influences preferred interests. Identification of early preferred interests commonly held by autistic toddlers could serve as a useful clinical indicator of future diagnosis. This article explored whether diagnostic group, age, sex, and cognitive ability predict the likelihood that parents reported preferred interests in children aged 12–36 months with diagnoses of autism, developmental delay, and those with no diagnosis. Additionally, we explored potential diagnostic group differences in interest type. Results suggest that diagnostic group, but not age, sex, or cognitive ability, predicts the likelihood that parents report preferred interests. No differences in the type of interests among diagnostic groups were identified. These results support the use of preferred interests as an early sign of autism but suggest that interest type may not be a helpful clinical indicator of autism in toddlerhood.
A one‐process production of completely biotinylated proteins in a T7 expression system
Authors: Kawashima Takuma , Nakamura Mitsuki , Sakono Masafumi 
Published: May 2024

AbstractStreptavidin is a tetrameric protein with high specificity and affinity for biotin. The interaction between avidin and biotin has become a valuable tool in nanotechnology. In recent years, the site‐specific biotin modification of proteins using biotin ligases, such as BirA, has attracted attention. This study established an in vivo method for achieving the complete biotinylation of target proteins using a single plasmid co‐expressing BirA and its target proteins. Specifically, a biotin‐modified protein was produced in Escherichia coli strain BL21(DE3) using a single plasmid containing genes encoding both BirA and a protein fused to BirA's substrate sequence, Avitag. This approach simplifies the production of biotinylated proteins in E. coli and allows the creation of various biotinylated protein types through gene replacement. Furthermore, the biotin modification rate of the obtained target protein could be evaluated using Native‐PAGE without performing complicated isolation operations of biotinylated proteins. In Native‐PAGE, biotin‐modified proteins and unmodified proteins were confirmed as clearly different bands, and it was possible to easily derive the modification rate from the respective band intensities.
Traditional social learning predicts cyber deviance? Exploring the offending versatility thesis in social learning theory
Authors: Zhou You , Liu Weidi , Lee Claire , Xu Boyang , Sun Ivan 
Published: May 2024

AbstractSocial learning theory has been widely implemented to understand cyber deviance. Nevertheless, the antecedent scholarship homogenously nested in the perspective of offending specification, leaving the offending versatility thesis unattained. The lack of such studies may undermine the capability of comprehensively understanding the social learning patterns of online offending. Using a sample of 3741 Chinese college students, this study estimated an array of binary logistic regressions to compare the effects of traditional and online social learning in four types of online offending (online sexual harassment, cyberbullying, hacking, and digital piracy). The results suggest that offending versatility and offending specification co‐exist in the social learning process of cyber deviance, while offending specification explains a marginally greater variance. Besides, online learning variables act as potential mediators in the relationships between traditional learning and cyber deviance. Furthermore, traditional social learning shows greater predictive power in cyber‐enabled crimes than in cyber‐dependent crimes. Our study provides fresh empirical evidence for the non‐exclusive association between offending versatility and offending specification in the social learning process of cyber deviance.
Abemaciclib plus endocrine therapy versus chemotherapy after progression on prior palbociclib in HR+/HER2‐ metastatic breast cancer: A single center real‐world study in China
Authors: Jiang Hanfang , Zhong Jianxin , Wang Jing , Song Guohong , Di Lijun , Shao Bin , Zhang Ruyan , Liu Yaxin , Zhu Anjie , Wang Nan , Li Huiping 
Published: May 2024

AbstractBackgroundCyclin‐dependent kinase (CDK) 4/6 inhibitor plus endocrine therapy (ET) become standard‐of‐care for patients with hormone receptor‐positive, human epidermal growth factor receptor‐2 negative (HR+/HER2−) metastatic breast cancer (MBC). However, the optimal therapeutic paradigm after progression on CDK4/6 inhibitor remains unclear. This study aimed to evaluate the efficacy and safety of abemaciclib with switching ET versus chemotherapy after progression on prior palbociclib‐based ET in Chinese patients with HR+/HER2− MBC.MethodsFrom 414 consecutive patients with HR+/HER2− MBC who had been treated with palbociclib plus ET from September 2018 to May 2022 in Peking University Cancer Hospital, we identified 80 patients who received abemaciclib plus switching ET or chemotherapy after progression on palbociclib, matched for age, original stage at diagnosis, disease‐free interval, and tumor burden at 1:1 ratio. The primary endpoint was progression‐free survival (PFS) compared using the Kaplan–Meier method. A Cox proportional hazard model was performed to identify clinical factors associated with PFS in the abemaciclib group.ResultsThe median PFS was 6.0 months (95% confidence interval [CI]: 3.94–8.06) in abemaciclib group and 4.0 months (95% CI, 2.52–5.49) in chemotherapy group (p = 0.667). And, there was no difference in median PFS between the sequential and nonsequential arm (6.0 vs. 6.0 months) in the abemaciclib group though fewer lines of prior systemic therapy and longer PFS from prior palbociclib in the sequential arm. However, patients with prior palbociclib as the first‐line therapy had a significantly longer median PFS versus prior palbociclib as ≥2nd‐line therapy (11.0 vs. 5.0 months, p = 0.043). Based on multivariable analysis, ER+/PR+ was an independent factor associated with longer PFS. There was no significant difference in overall survival between the abemaciclib and chemotherapy groups (p = 0.069).ConclusionOur findings indicate that abemaciclib plus switching ET might be one of feasible treatment options for Chinese patients with HR+/HER2− MBC after progression on prior palbociclib‐based therapy in addition to chemotherapy.
The double life of a chemotherapy drug: Immunomodulatory functions of gemcitabine in cancer
Authors: Larson Alaina C. , Doty Kenadie R. , Solheim Joyce C. 
Published: May 2024

AbstractAlthough the development of immunotherapies has been revolutionary in the treatment of several cancers, many cancer types remain unresponsive to immune‐based treatment and are largely managed by chemotherapy drugs. However, chemotherapeutics are not infallible and are frequently rendered ineffective as resistance develops from prolonged exposure. Recent investigations have indicated that some chemotherapy drugs have additional functions beyond their normative cytotoxic capacity and are in fact immune‐modifying agents. Of the pharmaceuticals with identified immune‐editing properties, gemcitabine is well‐studied and of interest to clinicians and scientists alike. Gemcitabine is a chemotherapy drug approved for the treatment of multiple cancers, including breast, lung, pancreatic, and ovarian. Because of its broad applications, relatively low toxicity profile, and history as a favorable combinatory partner, there is promise in the recharacterization of gemcitabine in the context of the immune system. Such efforts may allow the identification of suitable immunotherapeutic combinations, wherein gemcitabine can be used as a priming agent to improve immunotherapy efficacy in traditionally insensitive cancers. This review looks to highlight documented immunomodulatory abilities of one of the most well‐known chemotherapy agents, gemcitabine, relating to its influence on cells and proteins of the immune system.