bluuebunny/crossref_metadata_2025_split huggingface dataset:
Familial Predictors of Obsessive‐Compulsive Symptom Dimensions (Contamination/Cleaning and Symmetry/Ordering) in a Nonclinical Sample
Authors: Taberner Joan , Fullana Miquel A. , Caseras Xavier , Pertusa Alberto , Bados Arturo , van den Bree Marianne , Torrubia Rafael 
Published: May 2012

IntroductionObsessive–compulsive disorder (OCD) is a heterogeneous condition, which can be expressed as various symptom dimensions, including contamination/cleaning and symmetry/ordering. Previous research suggests that these obsessive‐compulsive (OC) dimensions may show specific associations with certain traits such as disgust sensitivity and “not just right” experiences (NJREs), but whether a familial association between these variables exists is unknown.ObjectivesThe goal of this study was to test whether parental disgust sensitivity and NJREs predicted contamination/cleaning and symmetry/ordering respectively in the offspring.MethodContamination/cleaning, symmetry/ordering, disgust sensitivity, NJREs, and negative affect were assessed in a nonclinical sample (n = 184 triads comprising 184 female undergraduates and their parents). Associations between parental and offspring variables were investigated by means of bivariate correlations and multiple regression models, controlling for relevant variables.ResultsNeither disgust sensitivity nor NJREs in parents were significant predictors of contamination/cleaning or symmetry/ordering in the offspring.ConclusionsCombined with previous research, our results suggest that the best familial predictors of OC symptom dimensions are the same symptom dimensions themselves.
Mechanisms of apoptosis by the tumor suppressor Par‐4
Authors: Hebbar Nikhil , Wang Chi , Rangnekar Vivek M. 
Published: May 2012

AbstractPar‐4 is a pro‐apoptotic, tumor suppressor protein that induces apoptosis selectively in cancer cells. Endoplasmic reticulum‐stress and higher levels of protein kinase A in tumor cells confer the coveted feature of cancer selective response to extracellular and intracellular Par‐4, respectively. Recent studies have shown that systemic Par‐4 confers resistance to tumor growth in mice, and that tumor‐resistance is transferable by bone‐marrow transplantation. Moreover, recombinant Par‐4 inhibits the growth of tumors in mice. As systemic Par‐4 induces apoptosis via cell surface GRP78, strategies that promote GRP78 trafficking to the cell surface are expected sensitize cancer cells to circulating levels of Par‐4. This review illustrates the domains and mechanisms by which Par‐4 orchestrates the apoptotic process in both cell culture models and in physiological settings. J. Cell. Physiol. 227: 3715–3721, 2012. © 2012 Wiley Periodicals, Inc.
Involvement of CaMK‐IIδ and gelsolin in Cd2+‐dependent cytoskeletal effects in mesangial cells
Authors: Liu Ying , Templeton Douglas M. 
Published: May 2012

AbstractCadmium is a toxic metal with pleiotropic effects on cell death and survival. The mesangial cell is particularly responsive to Cd's effects on kinase signaling pathways and cytoskeletal dynamics. Here we show that CaMK‐II is a participant in the cytoskeletal effects of Cd2+. A major mesangial cell isoform, CaMK‐IIδ, was identified in pellets of DNase I pull‐downs and cytosolic immunoprecipitates of G‐actin. CaMK‐IIδ was also present in Triton X‐100‐insoluble cytoskeletal preparations and translocated to the cytoskeleton in a concentration‐dependent manner in Cd‐treated cells. Translocation was suppressed by KN93, an inhibitor of CaMK‐II phosphorylation. In vitro actin polymerization studies indicated that recombinant CaMK‐IIδ sequestered actin monomer. Cytoskeletal preparations from Cd‐treated cells decrease the rate of polymerization, but KN93 co‐treatment prevents this effect. Over‐expressed CaMK‐IIδ also translocated to the cytoskeleton upon Cd exposure, and this was prevented by KN93. Conversely, siRNA silencing of CaMK‐IIδ increases the effect of cytoskeletal extracts on actin polymerization, and abrogates the effect of Cd. The actin capping and severing protein, gelsolin, translocates to the cytoskeleton in the presence of Cd2+, dependent upon the phosphorylation of CaMK‐II, and is recovered together with actin and CaMK‐IIδ in G‐actin pull‐downs and F‐actin sedimentation. Translocation is accompanied by generation of a 50 kDa gelsolin fragment whose appearance is prevented by KN93 and CaMK‐IIδ silencing. We conclude that cytoskeletal effects of Cd in mesangial cells are partially mediated by Cd‐dependent activation of CaMK‐IIδ, binding of CaMK‐IIδ and gelsolin to actin filaments, and cleavage of gelsolin. J. Cell. Physiol. 228: 78–86, 2013. © 2012 Wiley Periodicals, Inc.
Optimum scaling factors for one‐dimensional finite‐difference time‐domain scheme in Maxwell–Boltzmann system
Authors: Oh Il‐Young , Kim Deok‐Kyu , Yook Jong‐Gwan 
Published: May 2012

ABSTRACTThis paper proposes a new one‐dimensional finite‐difference time‐domain (1D‐FDTD) method to achieve accurate electromagnetic (EM) wave characteristics in plasma region for wideband signals. This paper utilizes Maxwell–Boltzmann system, which can analyze EM wave properties without effective permittivity model, such as Debye, Drude, or Lorentz model. It is the advantage of the proposed method that does not increase the complexity of the conventional FDTD algorithm while it provides accurate results. The proposed method employs two scaling factors that control electron density and collision frequency of plasma. And they are optimized to achieve minimum error in the frequency band of interest, and the optimized scaling factors are applied to the conventional FDTD method. The validity and effectiveness of the proposed method is verified by comparing electric field intensity in infinite plasma region with that of the analytic solution and the conventional FDTD method. Copyright © 2012 John Wiley & Sons, Ltd.
Critical carbon inputs to maintain soil organic carbon stocks under long‐term finger‐millet (Eleusine coracana [L.] Gaertn.) cropping on Alfisols in semiarid tropical India
Authors: Srinivasarao Cherukumalli , Venkateswarlu Bandi , Kumar Singh Anil , Pandu Ranga Vittal Kanuparthy , Kundu Sumanta , Ravindra Chary Gajjala , Narayanaiyer Gajanan Ganjigunte , Kogganur Ramachandrappa Basavapura 
Published: May 2012

AbstractEnrichment of soil organic carbon (SOC) stocks through sequestration of atmospheric CO2 in agricultural soils is important because of its impacts on adaptation to and mitigation of climate change while also improving crop productivity and sustainability. In a long‐term fertility experiment carried out over 27 y under semiarid climatic condition, we evaluated the impact of crop‐residue C inputs through rainfed fingermillet (Eleusine coracana [L.] Gaertn.) cropping, fertilization, and manuring on crop yield sustainability and SOC sequestration in a Alfisol soil profile up to a depth of 1 m and also derived the critical value of C inputs for maintenance of SOC. Five treatments, viz., control, farmyard manure (FYM) 10 Mg ha–1, recommended dose of NPK (50 : 50 : 25 kg N, P2O5, K2O ha–1), FYM 10 Mg ha–1 + 50% recommended dose of NPK, and FYM 10 Mg ha–1 + 100% recommended dose of NPK imposed in a randomized block design replicated four times. Application of FYM alone or together with mineral fertilizer resulted in a higher C input and consequently built up a higher C stock. After 27 y, higher profile SOC stock (85.7 Mg ha–1), C build up (35.0%), and C sequestration (15.4 Mg C ha–1) was observed with the application of 10 Mg FYM ha–1 along with recommended dose of mineral fertilizer and these were positively correlated with cumulative C input and well reflected in sustainable yield index (SYI). For sustenance of SOC level (zero change due to cropping) a minimum quantity of 1.13 Mg C is required to be added per hectare per annum as inputs. While the control lost C, the application of mineral fertilizer served to maintain the priori C stock. Thus, the application of FYM increased the C stock, an effect which was even enhanced by additional amendment of mineral fertilizer. We conclude that organic amendments contribute to C sequestration counteracting climate change and at the same time improve soil fertility in the semiarid regions of India resulting in higher and more stable yields.
Spectral stability estimates for the eigenfunctions of second order elliptic operators
Authors: Burenkov Victor I. , Feleqi Ermal 
Published: May 2012

AbstractStability of the eigenfunctions of nonnegative selfadjoint second‐order linear elliptic operators subject to homogeneous Dirichlet boundary data under domain perturbation is investigated. Let Ω, \documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}$\Omega ^{\prime } \subset \mathbb {R}^n$\end{document} be bounded open sets. The main result gives estimates for the variation of the eigenfunctions under perturbations Ω′ of Ω such that \documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}$\Omega _{\varepsilon } = \lbrace x \in \Omega : {\rm dist}(x,\, \mathbb {R}^n \!\setminus \! \Omega ) > \varepsilon \rbrace \subset \Omega ^{\prime } \subset \overline{\Omega ^{\prime }} \subset \Omega$\end{document} in terms of powers of ε, where the parameter ε > 0 is sufficiently small. The estimates obtained here hold under some regularity assumptions on Ω, Ω′. They are obtained by using the notion of a gap between linear operators, which has been recently extended by the authors to differential operators defined on different open sets.
Extension of Beckert's Continuation Method to Variational Inequalities
Authors: Miersemann Erich , Mittelmann Hans D. 
Published: May 2012

AbstractA theoretical foundation is given for a recently proposed continuation method for parameter‐dependent nonlinear variational inequalities in Hilbert space. The second derivative of one of the functional in the inequality is assumed to generate a quadratic form that is equivalent to the norm of the Hilbert space. The value of this functional is used as continuation parameter. Existence of local continuations is shown using a generalization of Beckert's continuation method for eigenvalue equations and extending continuation results obtained recently by the nuthors. In addition, uniqueness and monotonicity results are proven for these continuations.
Well Posed Variational Problems and Friedrichs Extensions
Authors: Dinca G. , Mateescu D. 
Published: May 2012

AbstractIn this paper the concept of well posed variational problem is studied for the pair (P, Ff where P is a multivoque operator from B(P) c X into 2 X and 3,. is a convex functiont, Convenient hypotheses show that if the variational problem for the pair (P, 3 p) is well will then P can be extended up to a maximal monotone and surjective operator. Several applitint A (“temperature control” included) are also considered.
Assessing Advertising Effectiveness: The Potential of Goal‐Directed Behavior
Authors: Berger Sebastian , Wagner Udo , Schwand Christopher 
Published: May 2012

ABSTRACTAdvertising clutter and declining audience attention means advertisers need pretesting to ensure the effectiveness of their advertisements. This study uses, for the first time, a variable‐resolution display to measure viewers’ visual attention to advertising. The display features only the part of an ad that corresponds with the observer's eye gaze with high acuity, whereas the resolution of the other parts reflects the decline in spatial resolution of the human visual system. Participants keep the highest resolution area aligned with their foveal vision using manual cursor movements. In accordance with neuroscientific theory, recorded cursor movements parallel the eye gaze patterns observed in a control group. However, unlike tracking eye movements, the instrument offers a simple, unobtrusive, low‐cost, and time‐efficient way to measure the effectiveness of visual advertising. The results encourage the use of goal‐directed manual pointing movements to indicate attentional signals generated in the brain.
Trust, Commitment, and Older Women: Exploring Brand Attachment Differences in the Elderly Segment
Authors: Jahn Steffen , Gaus Hansjoerg , Kiessling Tina 
Published: May 2012

ABSTRACTUnderstanding older adults’ product consumption behavior is of high importance to consumer and marketing research. Prior studies have mainly focused on older adults’ cognitive decline and compared their behavior to that of younger consumers. A neglected area of research has been older consumers’ brand attachment that is associated with potential differences between consumers in their fifties and in their seventies. In this article, the authors provide insights into the under‐researched field of elderly women's brand attachment. Drawing on socioemotional selectivity theory, a shift toward emotional aspects in brand relationships is proposed. A model involving trust and commitment processes is developed and empirically tested in a survey among 341 older women. Moderator analyses reveal significant differences between the “younger elderly” and the “older elderly” in relationships among self‐concept connection, partner quality, trust, and commitment. For the younger elderly, how a brand is (based on trust judgments) seems to be more important. For the older elderly, what a brand does in its role as relationship partner becomes more relevant.
Dazing Diversity: Investigating the Determinants and Consequences of Decision Paralysis
Authors: Huber Frank , Köcher Sören , Vogel Johannes , Meyer Frederik 
Published: May 2012

ABSTRACTThis article makes new contributions to the assessment of negative effects on consumer choice behavior due to high product variety by (1) developing a holistic framework to identify the determinants and, for the first time, consequences of decision paralysis; (2) introducing a novel construct, namely, tendencies toward paralysis, that refers to the extent of decision makers’ preference (a) to maintain the status quo, (b) to omit, and/or (c) to delay choice, as well as providing an appropriate measurement model incorporating these three dimensions of decision paralysis that previously have been analyzed only separately; and (3) analyzing potential moderating effects of decision makers’ predisposition toward maximizing on the proposed model. The developed structural equation model as well as the conceptualization and operationalization of the novel construct are verified using data from the German cellular phone market. The model constructs of preference uncertainty and anticipated regret are evidenced to be the fundamental drivers of the formation of tendencies toward paralysis. In this context, the characteristics of variety under consideration—number, alignability, and complexity of alternatives—turn out to be appropriate parameters in avoiding decision paralysis. Moreover, a significant negative relationship between tendencies toward paralysis and subsequent customer satisfaction points out the importance of these findings for future research and business practice.
A theoretical and experimental proteome map of Pseudomonas aeruginosa PAO1
Authors: Lecoutere Elke , Verleyen Peter , Haenen Steven , Vandersteegen Katrien , Noben Jean‐Paul , Robben Johan , Schoofs Liliane , Ceyssens Pieter‐Jan , Volckaert Guido , Lavigne Rob 
Published: May 2012

AbstractA total proteome map of the Pseudomonas aeruginosa PAO1 proteome is presented, generated by a combination of two‐dimensional gel electrophoresis and protein identification by mass spectrometry. In total, 1128 spots were visualized, and 181 protein spots were characterized, corresponding to 159 different protein entries. In particular, protein chaperones and enzymes important in energy conversion and amino acid biosynthesis were identified. Spot analysis always resulted in the identification of a single protein, suggesting sufficient spot resolution, although the same protein may be detected in two or more neighboring spots, possibly indicating posttranslational modifications. Comparison to the theoretical proteome revealed an underrepresentation of membrane proteins, though the identified proteins cover all predicted subcellular localizations and all functional classes. These data provide a basis for subsequent comparative studies of the biology and metabolism of P. aeruginosa, aimed at unraveling global regulatory networks.
Dystonia in corticobasal degeneration: A review of the literature on 404 pathologically proven cases
Authors: Stamelou Maria , Alonso‐Canovas Araceli , Bhatia Kailash P. 
Published: May 2012

AbstractDystonia is considered one of the classical features of corticobasal degeneration and is reported in up to 83% in clinical, not pathologically confirmed, series. Here, we aimed to establish the frequency and the clinical characteristics of dystonia in CBD by reviewing the literature on 404 pathologically proven cases. Further, we aimed to identify the frequency and characteristics of dystonia in all described phenotypes with CBD pathology. Dystonia was present in only 37.5% of the 296 cases with adequate information. The majority of the cases with dystonia presented with a corticobasal syndrome, and dystonia occurred in the first 2 years from disease onset, affecting the upper limb. In cases with dystonia that presented with a “dementia” phenotype, dystonia tended to appear later in the disease course and to more affect the cervical region and the face. With regard to the distribution of the phenotypes, fifty‐four percent of 374 cases presented as corticobasal syndrome, 15% as frontotemporal dementia, and 10.7% as progressive supranuclear palsy. Dystonia and myoclonus were present in about half of all cases with corticobasal syndrome, implying that these features may not be as frequent in corticobasal syndrome as are akinetic‐rigid syndrome and apraxia (100% and 86.3%, respectively). Dystonia and myoclonus almost co‐occurred in our analysis, suggesting a possible association. In conclusion, despite dystonia being an inclusion criterion in all sets of clinical criteria for corticobasal degeneration, this was present in only one third of the pathologically proven cases presented here. More accurate characterization of dystonia in corticobasal degeneration would be of importance for clinical diagnosis and development of treatment strategies. © 2012 Movement Disorder Society
Small Molecule Modulators of Keap1‐Nrf2‐ARE Pathway as Potential Preventive and Therapeutic Agents
Authors: Magesh Sadagopan , Chen Yu , Hu Longqin 
Published: May 2012

AbstractKelch‐like ECH‐associated protein 1 (Keap1)‐nuclear factor erythroid 2‐related factor 2 (Nrf2)‐antioxidant response elements (ARE) pathway represents one of the most important cellular defense mechanisms against oxidative stress and xenobiotic damage. Activation of Nrf2 signaling induces the transcriptional regulation of ARE‐dependent expression of various detoxifying and antioxidant defense enzymes and proteins. Keap1‐Nrf2‐ARE signaling has become an attractive target for the prevention and treatment of oxidative stress‐related diseases and conditions including cancer, neurodegenerative, cardiovascular, metabolic, and inflammatory diseases. Over the last few decades, numerous Nrf2 inducers have been developed and some of them are currently undergoing clinical trials. Recently, overactivation of Nrf2 has been implicated in cancer progression as well as in drug resistance to cancer chemotherapy. Thus, Nrf2 inhibitors could potentially be used to improve the effectiveness of cancer therapy. Herein, we review the signaling mechanism of Keap1‐Nrf2‐ARE pathway, its disease relevance, and currently known classes of small molecule modulators. We also discuss several aspects of Keap1–Nrf2 interaction, Nrf2‐based peptide inhibitor design, and the screening assays currently used for the discovery of direct inhibitors of Keap1‐Nrf2 interaction. © 2012 Wiley Periodicals, Inc. Med Res Rev., 32, No. 4, 687‐726, 2012
DNA‐Binding Small Molecules as Inhibitors of Transcription Factors
Authors: Leung Chung‐Hang , Chan Daniel Shiu‐Hin , Ma Victor Pui‐Yan , Ma Dik‐Lung 
Published: May 2012

AbstractAccumulating evidence implicating the role of aberrant transcription factor signaling in the pathogenesis of various human diseases such as cancer and inflammation has stimulated the development of small molecule ligands capable of targeting transcription factor activity and modulating gene expression. The use of DNA‐binding small molecules to selectively inhibit transcription factor–DNA interactions represents one possible approach toward this goal. In this review, we summarize the development of DNA‐binding small molecule inhibitors of transcription factors from 2004 to 2011, and their binding mode and therapeutic potential will be discussed.
Networks of ProteinProtein Interactions: From Uncertainty to Molecular Details
Authors: Garcia‐Garcia Javier , Bonet Jaume , Guney Emre , Fornes Oriol , Planas Joan , Oliva Baldo 
Published: May 2012

AbstractProteins are the bricks and mortar of cells. The work of proteins is structural and functional, as they are the principal element of the organization of the cell architecture, but they also play a relevant role in its metabolism and regulation. To perform all these functions, proteins need to interact with each other and with other bio‐molecules, either to form complexes or to recognize precise targets of their action. For instance, a particular transcription factor may activate one gene or another depending on its interactions with other proteins and not only with DNA. Hence, the ability of a protein to interact with other bio‐molecules, and the partners they have at each particular time and location can be crucial to characterize the role of a protein. Proteins rarely act alone; they rather constitute a mingled network of physical interactions or other types of relationships (such as metabolic and regulatory) or signaling cascades. In this context, understanding the function of a protein implies to recognize the members of its neighborhood and to grasp how they associate, both at the systemic and atomic level. The network of physical interactions between the proteins of a system, cell or organism, is defined as the interactome. The purpose of this review is to deepen the description of interactomes at different levels of detail: from the molecular structure of complexes to the global topology of the network of interactions. The approaches and techniques applied experimentally and computationally to attain each level are depicted. The limits of each technique and its integration into a model network, the challenges and actual problems of completeness of an interactome, and the reliability of the interactions are reviewed and summarized. Finally, the application of the current knowledge of protein‐protein interactions on modern network medicine and protein function annotation is also explored.
Comparison of quality of life measures in Korean menopausal women
Authors: Shin Hyunjeong 
Published: May 2012

AbstractThe psychometric properties of two menopause‐specific quality of life (QoL) measures, the Menopausal Quality of Life (MQOL), and the Women's Health Questionnaire (WHQ), were evaluated and compared in a convenience sample of 304 Korean women in menopausal transition. Data were collected with a self‐report questionnaire. Evaluation of validity included factor analysis, convergent and discriminant validity, and known‐groups validity. Evaluation of reliability included internal consistency reliability and item analysis. The results indicated that both QoL instruments were valid, but the WHQ was more internally consistent in measuring QoL although with a factor structure different from previous research. Replication studies to identify factor structures are needed for both measures. © 2012 Wiley Periodicals, Inc. Res Nurs Health 35:383–396, 2012