bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insubordination and the rise of absolutism: the Mercure françois under Richelieu
Authors: Paton Caspar 
Published: May 2024

Abstract
It is often argued that Cardinal Richelieu appropriated the Mercure françois, France’s first printed newspaper, immediately upon entering the king’s council in 1624. This consensus originates in a questionable nineteenth-century work by Louis Dedouvres yet has not been seriously challenged, seemingly because it tallies neatly with traditional étatiste understandings of Richelieu as a great state-builder. By refuting Richelieu’s control over the Mercure during the 1620s, this article buttresses revisionist re-evaluations of his influence over the French state during that period. It extends such revisionism to Richelieu’s regulation of the mainstream press and public sphere, and suggests the Mercure represents a valuable alternative source through which the earliest years of his second ministry might be better apprehended.
Benfotiamine improves dystrophic pathology and exercise capacity in mdx mice by reducing inflammation and fibrosis
Authors: Coles Chantal A , Woodman Keryn G , Gibbs Elizabeth M , Crosbie Rachelle H , White Jason D , Lamandé Shireen R 
Published: May 2024

Abstract
Duchenne Muscular Dystrophy (DMD) is a progressive and fatal neuromuscular disease. Cycles of myofibre degeneration and regeneration are hallmarks of the disease where immune cells infiltrate to repair damaged skeletal muscle. Benfotiamine is a lipid soluble precursor to thiamine, shown clinically to reduce inflammation in diabetic related complications. We assessed whether benfotiamine administration could reduce inflammation related dystrophic pathology. Benfotiamine (10 mg/kg/day) was fed to male mdx mice (n = 7) for 15 weeks from 4 weeks of age. Treated mice had an increased growth weight (5–7 weeks) and myofibre size at treatment completion. Markers of dystrophic pathology (area of damaged necrotic tissue, central nuclei) were reduced in benfotiamine mdx quadriceps. Grip strength was increased and improved exercise capacity was found in mdx treated with benfotiamine for 12 weeks, before being placed into individual cages and allowed access to an exercise wheel for 3 weeks. Global gene expression profiling (RNAseq) in the gastrocnemius revealed benfotiamine regulated signalling pathways relevant to dystrophic pathology (Inflammatory Response, Myogenesis) and fibrotic gene markers (Col1a1, Col1a2, Col4a5, Col5a2, Col6a2, Col6a2, Col6a3, Lum) towards wildtype levels. In addition, we observed a reduction in gene expression of inflammatory gene markers in the quadriceps (Emr1, Cd163, Cd4, Cd8, Ifng). Overall, these data suggest that benfotiamine reduces dystrophic pathology by acting on inflammatory and fibrotic gene markers and signalling pathways. Given benfotiamine’s excellent safety profile and current clinical use, it could be used in combination with glucocorticoids to treat DMD patients.
In vitro activity of cefiderocol in Pseudomonas aeruginosa isolates from people with cystic fibrosis recovered during three multicentre studies in Spain
Authors: Maruri-Aransolo Ainhize , López-Causapé Carla , Hernández-García Marta , García-Castillo María , Caballero-Pérez Juan de Dios , Oliver Antonio , Cantón Rafael 
Published: May 2024

Abstract

Objectives
Despite the introduction of cystic fibrosis transmembrane conductance regulator (CFTR) modulators, Pseudomonas aeruginosa is still a major pathogen in people with cystic fibrosis (pwCF). We determine the activity of cefiderocol and comparators in a collection of 154 P. aeruginosa isolates recovered from pwCF during three multicentre studies performed in 17 Spanish hospitals in 2013, 2017 and 2021.

Methods
ISO broth microdilution was performed and MICs were interpreted with CLSI and EUCAST criteria. Mutation frequency and WGS were also performed.

Results
Overall, 21.4% were MDR, 20.8% XDR and 1.3% pandrug-resistant (PDR). Up to 17% of the isolates showed a hypermutator phenotype. Cefiderocol demonstrated excellent activity; only 13 isolates (8.4%) were cefiderocol resistant by EUCAST (none using CLSI). A high proportion of the isolates resistant to ceftolozane/tazobactam (71.4%), meropenem/vaborbactam (70.0%), imipenem/relebactam (68.0%) and ceftazidime/avibactam (55.6%) were susceptible to cefiderocol. Nine out of 13 cefiderocol-resistant isolates were hypermutators (P &lt; 0.001). Eighty-three STs were detected, with ST98 being the most frequent. Only one isolate belonging to the ST175 high-risk clone carried blaVIM-2. Exclusive mutations affecting genes involved in membrane permeability, AmpC overexpression (L320P-AmpC) and efflux pump up-regulation were found in cefiderocol-resistant isolates (MIC = 4–8 mg/L). Cefiderocol resistance could also be associated with mutations in genes related to iron uptake (tonB-dependent receptors and pyochelin/pyoverdine biosynthesis).

Conclusions
Our results position cefiderocol as a therapeutic option in pwCF infected with P. aeruginosa resistant to most recent β-lactam/β-lactamase inhibitor combinations.
Influencing attitudes towards antimicrobial use and resistance in companion animals—the impact on pet owners of a short animation in a randomized controlled trial
Authors: Wright Emma , Jessen Lisbeth Rem , Tompson Alice , Rutland Catherine , Singleton David , Battersby Ian , Gajanayake Isuru , Mosher Margo , Pfleger Sharon , Gemmill Toby , Sparks Tim , Sørensen Tina M , Allerton Fergus 
Published: May 2024

Abstract

Objectives
Antimicrobial resistance (AMR) is a vital One Health issue; the rational use of antimicrobials is essential to preserve their efficacy. Veterinarians cite pressure from pet owners as a contributor to antimicrobial prescription. Engaging pet owners in antimicrobial stewardship could reduce this pressure. A short educational animation could facilitate communication of this message. The impact of the animation on participant’s opinions relating to antimicrobial prescribing and awareness of AMR was assessed via a randomized controlled trial.

Methods
A survey was created based on the health belief model. Owners attending six UK veterinary centres were randomized to the intervention or control group (ratio 1:1). All owners completed an agreement level survey of two questions followed by 18 statements scored using a Likert agreement scale. The control group responded without interruption, whereas the animation group was shown the animation after answering the first two questions and five statements.

Results
In total, 647 owners participated in the study; 350 complete responses were analysed. Responses to 10 of 13 statements asked after the animation were significantly different (all P &lt; 0.050) between groups, whereas there was no significant difference between groups in response to any of the statements asked before the animation. The animation group were more likely to agree that lower antimicrobial use would help maintain future efficacy (P &lt; 0.001) and that requesting antimicrobials from their vet could increase unnecessary use (P &lt; 0.001). The animation group were more likely to disagree that they would expect antimicrobials if their pet had diarrhoea (P = 0.048).

Conclusions
Pet owners that watched a short AMR engagement animation displayed greater awareness of the impact of AMR and were more likely to support measures in line with antimicrobial stewardship. This behavioural-nudge resource could support owners towards contributing to a multi-faceted approach to AMR.
Clinical significance of cefazolin inoculum effect in serious MSSA infections: a systematic review
Authors: Lo Calvin Ka-Fung , Sritharan Ashwin , Zhang Jiesi , Li Nicole , Zhang Cindy , Wang Frank , Loeb Mark , Bai Anthony D 
Published: May 2024

Abstract

Background
The cefazolin inoculum effect (CzIE) is a phenomenon whereby some MSSA isolates demonstrate resistance to cefazolin when a high bacterial inoculum is used for susceptibility testing. The clinical significance of this phenotypic phenomenon remains unclear. We conducted a systematic review to answer the following question: In patients with serious MSSA infection treated with cefazolin, does infection due to CzIE-positive MSSA isolates result in worse clinical outcomes than infection due to CzIE-negative MSSA isolates?

Methods
Ovid MEDLINE, Embase, Cochrane CENTRAL, medRxiv and bioRxiv were searched from inception until 12 April 2023. Studies were included if they tested for CzIE in clinical isolates from MSSA infections in humans. Two independent reviewers extracted data and conducted risk-of-bias assessment. Main outcomes were treatment failure and mortality. Pooling of study estimates was not performed given the heterogeneity of patient populations and outcome definitions.

Results
Twenty-three observational studies were included. CzIE presence amidst MSSA isolates ranged from 0% to 55%. There was no statistically significant mortality difference in two studies that compared MSSA infections with and without CzIE, with ORs ranging from 0.72 to 19.78. Of four studies comparing treatment failure, ORs ranged from 0.26 to 13.00. One study showed a significantly higher treatment failure for the CzIE group, but it did not adjust for potential confounders.

Conclusions
The evidence on CzIE is limited by small observational studies. In these studies, CzIE did not predict higher mortality in MSSA infections treated with cefazolin. Our findings do not support CzIE testing in clinical practice currently.
Intravenous cefuroxime as a first-line treatment for women hospitalized for pyelonephritis
Authors: Everard Céline , Schampaert Axelle , Doyen Louise , Verbelen Valérie , Marot Jean-Christophe , Wieërs Grégoire 
Published: May 2024

Abstract

Background
Empirical treatment of pyelonephritis in the emergency ward includes broad-spectrum antibiotics. Such a strategy favours broad-spectrum antibiotic overuse. Local antibiotic stewardship teams can propose local recommendations to adapt empirical antibiotic treatment devoted to spare precious molecules that remain active on MDR bacteria, such as fluoroquinolones or other broad-spectrum antibiotics.

Objectives
We aimed to evaluate the incidence of urinary tract infection recurrence within 3 months after hospital discharge following empirical antibiotic therapy with cefuroxime in women with pyelonephritis in the emergency room.

Patients and methods
We conducted a retrospective, single-centre study. We identified 109 women treated for pyelonephritis, 95 with cefuroxime at any time, and 14 with only other antibiotics, and divided them into subgroups based on antibiotic switch to other molecules. We compared the incidence of urinary tract infection recurrence in the subgroups.

Results
In the group of patients treated with cefuroxime only, we identified five cases of recurrence (9.4%) in a total of 53 patients, but only 1 (1.9%) case of recurrence associated with the same uropathogen. No significant difference in clinical outcome, length of antibiotic treatment, or urinary tract infection recurrence was observed between the subgroups.

Conclusions
Our study supports that a strategy elaborated by an antibiotic stewardship team based on local ecology and aimed at proposing the narrowest-spectrum antibiotic upon treatment initiation in the emergency room is safe.
Ataxia telangiectasia and Rad3-related (ATR) inhibitor camonsertib dose optimization in patients with biomarker-selected advanced solid tumors (TRESR study)
Authors: Fontana Elisa , Rosen Ezra , Lee Elizabeth K , Højgaard Martin , Mettu Niharika B , Lheureux Stephanie , Carneiro Benedito A , Cote Gregory M , Carter Louise , Plummer Ruth , Mahalingam Devalingam , Fretland Adrian J , Schonhoft Joseph D , Silverman Ian M , Wainszelbaum Marisa , Xu Yi , Ulanet Danielle , Koehler Maria , Yap Timothy A 
Published: May 2024

Abstract

Background
Camonsertib is a selective oral inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase with demonstrated efficacy in tumors with DNA damage response gene deficiencies. On-target anemia is the main drug-related toxicity typically manifesting after the period of dose-limiting toxicity evaluation. Thus, dose and schedule optimization requires extended follow-up to assess prolonged treatment effects.

Methods
Long-term safety, tolerability, and antitumor efficacy of 3 camonsertib monotherapy dosing regimens were assessed in the TRESR study dose-optimization phase: 160 mg once daily (QD) 3 days on, 4 days off (160 3/4; the preliminary recommended Phase II dose [RP2D]) and two step-down groups of 120 mg QD 3/4 (120 3/4) and 160 mg QD 3/4, 2 weeks on, 1 week off (160 3/4, 2/1w). Safety endpoints included incidence of treatment-related adverse events (TRAEs), dose modifications, and transfusions. Efficacy endpoints included overall response rate, clinical benefit rate, progression-free survival, and circulating tumor DNA (ctDNA)-based molecular response rate.

Results
The analysis included 119 patients: 160 3/4 (n = 67), 120 3/4 (n = 25), and 160 3/4, 2/1w (n = 27) treated up to 117.1 weeks as of the data cutoff. The risk of developing grade 3 anemia was significantly lower in the 160 3/4, 2/1w group compared with the preliminary RP2D group (hazard ratio = 0.23, 2-sided P = .02), translating to reduced transfusion and dose reduction requirements. The intermittent weekly schedule did not compromise antitumor activity.

Conclusion
The 160 3/4, 2/1w dose was established as an optimized regimen for future camonsertib monotherapy studies offering a substantial reduction in the incidence of anemia without any compromise to efficacy.

Clinical Trial ID
NCT04497116.
Effects of 1-hour computer use on ulnar and median nerve conduction velocity and muscle activity in office workers
Authors: Threesittidath Kanruethai , Chaibal Supattra , Nitayarak Haifah 
Published: May 2024

Abstract

Objectives
To compare the effects of 1-hour computer use on ulnar and median nerve conduction velocity and muscle activity in office workers with symptomatic neck pain and asymptomatic office workers.

Methods
A total of 40 participants, both male and female office workers, with symptomatic neck pain (n = 20) and asymptomatic (n = 20), were recruited. Pain intensity, ulnar nerve conduction velocity, median nerve conduction velocity, and muscle activity were determined before and after 1 hour of computer use.

Results
There was a significant increase in pain intensity in the neck area in both groups (P &lt; .001). The symptomatic neck pain group revealed a significant decrease in the sensory nerve conduction velocity of the ulnar nerve (P = .008), whereas there was no difference in the median nerve conduction velocity (P &gt; .05). Comparing before and after computer use, the symptomatic neck pain group had less activity of the semispinalis muscles and higher activity of the anterior scalene muscle than the asymptomatic group (P &lt; .05). The trapezius and wrist extensor muscles showed no significant differences in either group (P &gt; .05).

Conclusions
This study found signs of neuromuscular deficit of the ulnar nerve, semispinalis muscle, and anterior scalene muscle after 1 hour of computer use among office workers with symptomatic neck pain, which may indicate the risk of neuromuscular impairment of the upper extremities. The recommendation of resting, and encouraging function and flexibility of the neuromuscular system after 1 hour of computer use should be considered.
A reflection on a womanist theologian’s endeavour to dismantle whiteness, through creating the religious education module ‘Black Religion and Protest’
Authors: Brown Alexandra 
Published: May 2024

Abstract
In his seminal work After Whiteness: An Education in Belonging, Willie Jennings defines a concept he calls ‘whiteness’ and states that this plays the role of the ‘Paterfamilias’, a term born within the Greco–Roman period, which refers to the social system of rule and governance that was centred around the father–master archetype. During slavery, Jennings states that it was on the plantation that the life, logic, and social order of whiteness transpired. The more I engaged with Jennings’ work, the more I began to realize the extent to which the religious education curriculum, and by extension the English education system curriculum, further perpetuated whiteness. Inspired by the works of Jennings and the activism of Black Lives Matter (BLM) following the murder of George Floyd, I was motivated to create and teach a unit in the religious education (RE) curriculum, ‘Black Religion and Protest’. As well as examining the teaching and reception of this unit, this article seeks to unpack the ways in which Britain’s colonial legacy maintains epistemological inequity and hierarchical knowledge.
Small Area Prediction for Exponential Dispersion Families Under Informative Sampling
Authors: Berg Emily , Eideh Abdulhakeem 
Published: May 2024

Abstract
Small area estimates are usually constructed from complex survey data. If the design is informative for the model, then procedures that ignore the sample design can suffer from important biases. Past work on small area estimation under informative sampling has focused heavily on linear models or on the prediction of means. We propose to generalize existing small area procedures for an informative sample design. We develop procedures in the context of a broad class of exponential dispersion families with random small area effects. We consider two models for the survey weights. We construct predictions of means as well as more general parameters that are nonlinear functions of the model response variable. We evaluate the procedures through simulation using a logistic mixed model. We then apply the methods to construct small area estimates of several functions of a wetlands indicator using data from the National Resources Inventory, a large scale agricultural survey.
Exploring lipid–protein interactions in plant membranes
Authors: Škrabálková Eliška , Pejchar Přemysl , Potocký Martin 
Published: May 2024

Abstract
Once regarded as mere membrane building blocks, lipids are now recognized as diverse and intricate players that mold the functions, identities, and responses of cellular membranes. Although the interactions of lipids with integral and peripheral membrane proteins are crucial for their localization, activity, and function, how proteins bind lipids is still far from being thoroughly explored. Describing and characterizing these dynamic protein–lipid interactions is thus essential to understanding the membrane-associated processes. Here we review the current range of experimental techniques employed to study plant protein–lipid interactions, integrating various methods. We summarize the principles, advantages, and limitations of classical in vitro biochemical approaches, including protein–lipid overlays and various liposome binding assays, and complement them with in vivo microscopic techniques centered around the use of genetically encoded lipid sensors and pharmacological or genetic membrane lipid manipulation tools. We also highlight several emerging techniques still awaiting their advancement into plant membrane research and emphasize the need to use complementary experimental strategies as key for elucidating the mechanistic roles of protein–lipid interactions in plant cell biology.
Immunological biomarkers in patients with radiographic axial spondyloarthritis, an exploratory longitudinal Swedish study
Authors: Hellman Urban , Lejon Kristina , Do Lan , Geijer Mats , Baraliakos Xenofon , Witte Torsten , Forsblad-d’Elia Helena 
Published: May 2024

ABSTRACT

Objectives
There is a need for more specific biomarkers to diagnose and predict disease course in patients with axial spondyloarthritis (axSpA). This study aimed to study immunological plasma biomarkers at different time-points in radiographic (r)-axSpA patients overall and stratified by sex and compare these biomarker patterns in r-axSpA patients concerning disease phenotypes and disease activity.

Methods
Plasma samples were analysed from r-axSpA patients at and prior (Pre-Backbone) inclusion in the Backbone study. Interferon gamma, interleukin-10, -17A, -17F, -22, -23, -6, MCP-1, TNF-α, VEGF-A, MIF, IgA anti-CD74, zonulin, ESR, hsCRP, white blood cell count, and blood lipids were measured.

Results
Biomarker pattern discriminated significantly between r-axSpA patients in Backbone and Pre-Backbone compared with controls. When stratifying by sex, it was possible to discriminate between male and female r-axSpA patients in Backbone vs controls and between male r-axSpA patients in pre-Backbone and controls. In Backbone, markers with high discriminative capacity were MIF, IgA anti-CD74, and MCP-1. In Pre-Backbone, IL-6, TNF-α, MIF, triglycerides, cholesterol, IL-10, and zonulin displayed high discriminative capacity.

Conclusion
Based on their temporal pattern and mutual relationship, we suggest studying MIF, IgA anti-CD74, and MCP-1 in depth, at more time points, to further elucidate disease-driving mechanisms in this complex disease.
Multisite Study of the Management of Musculoskeletal Infection After Trauma: The MMUSKIT Study
Authors: Seidelman Jessica , Ritter Alaina S , Poehlein Emily , Green Cynthia L , Briggs Damon V , Chari Tristan , Therien Aaron D , Aitchison Alexandra Hunter , Lunn Kiera , Zirbes Christian F , Manohar Tanvi , Rijo Diana V , Hagen Jennifer E , Talerico Michael T , DeBaun Malcolm R , Pean Christian A , Certain Laura , Nelson Sandra B 
Published: May 2024

Abstract

Background
The optimal duration and choice of antibiotic for fracture-related infection (FRI) is not well defined. This study aimed to determine whether antibiotic duration (≤6 vs &gt;6 weeks) is associated with infection- and surgery-free survival. The secondary aim was to ascertain risk factors associated with surgery- and infection-free survival.

Methods
We performed a multicenter retrospective study of patients diagnosed with FRI between 2013 and 2022. The association between antibiotic duration and surgery- and infection-free survival was assessed by Cox proportional hazard models. Models were weighted by the inverse of the propensity score, calculated with a priori variables of hardware removal; infection due to Staphylococcus aureus, Staphylococcus lugdunensis, Pseudomonas or Candida species; and flap coverage. Multivariable Cox proportional hazard models were run with additional covariates including initial pathogen, need for flap, and hardware removal.

Results
Of 96 patients, 54 (56.3%) received ≤6 weeks of antibiotics and 42 (43.7%) received &gt;6 weeks. There was no association between longer antibiotic duration and surgery-free survival (hazard ratio [HR], 0.95; 95% CI, .65–1.38; P = .78) or infection-free survival (HR, 0.77; 95% CI, .30–1.96; P = .58). Negative culture was associated with increased hazard of reoperation or death (HR, 3.52; 95% CI, 1.99–6.20; P &lt; .001) and reinfection or death (HR, 3.71; 95% CI, 1.24–11.09; P &lt; .001). Need for flap coverage had an increased hazard of reoperation or death (HR, 3.24; 95% CI, 1.61–6.54; P = .001).

Conclusions
The ideal duration of antibiotics to treat FRI is unclear. In this multicenter study, there was no association between antibiotic treatment duration and surgery- or infection-free survival.
Evaluation of Posaconazole Serum Concentrations Achieved With Delayed-release Tablets and Oral Suspension in Patients Undergoing Intensive Chemotherapy for Acute Myeloid Leukemia and Myelodysplastic Syndrome
Authors: Muehlberg Leonora , Pabst Thomas , Largiadèr Carlo , Aebi Yolanda , Hayoz Michael , Muehlethaler Konrad , Zimmerli Stefan , Hirzel Cédric 
Published: May 2024

Abstract
Data on posaconazole serum levels of patients on prophylaxis with delayed-release tablets or oral suspension during intensive chemotherapy for acute myeloid leukemia and myelodysplastic syndrome are scarce. In this analysis, the proportion of patients with acute myeloid leukemia/myelodysplastic syndrome achieving posaconazole target concentrations with delayed-release tablets was higher than with oral suspension.