bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Language Phenotype of Children and Adolescents With Noonan Syndrome
Authors: Pierpont Elizabeth I. , Ellis Weismer Susan , Roberts Amy E. , Tworog-Dube Erica , Pierpont Mary Ella , Mendelsohn Nancy J. , Seidenberg Mark S. 
Published: June 2010

Purpose
This study presents an analysis of language skills in individuals with Noonan syndrome (NS), an autosomal dominant genetic disorder. We investigated whether the language impairments affecting some individuals arise from deficits specifically within the linguistic system or whether they are associated with cognitive, perceptual, and motor factors. Comparisons of language abilities among the different NS genotypes were also conducted.

Method
Sixty-six children and adolescents with NS were evaluated using standardized speech, language, and literacy assessments. Additional cognitive, perceptual, and motor tasks were administered to examine the relation of these factors to language development. Genotype was noted for those who underwent genetic testing.

Results

Language impairments were more frequent in NS than in the general population and were associated with higher risk for reading and spelling difficulties. Language was significantly correlated with nonverbal cognition, hearing ability, articulation, motor dexterity, and phonological memory. Genotype analyses suggest that the higher performance of
SOS1-
positive than
PTPN11-
positive individuals on language tasks was largely mediated by differences in cognitive ability.

Conclusions
Our results indicate that variation in language skill in NS is closely related to cognitive, perceptual, and motor factors. It does not appear that specific aspects of language are selectively affected in this syndrome.
Differentiating the Effects of Phonotactic Probability and Neighborhood Density on Vocabulary Comprehension and Production: A Comparison of Preschool Children With Versus Without Phonological Delays
Authors: Storkel Holly L. , Maekawa Junko , Hoover Jill R. 
Published: June 2010

PurposeTo differentiate the effect of phonotactic probability from that of neighborhood density on a vocabulary probe administered to preschool children with or without phonological delays.MethodTwenty preschool children with functional phonological delays and 34 preschool children with typical language development completed a 121-item vocabulary probe in both an expressive and receptive response format. Words on the vocabulary probe orthogonally varied on phonotactic probability and neighborhood density but were matched on age of acquisition, word frequency, word length, semantic set size, concreteness, familiarity, and imagability.ResultsResults show a Phonotactic Probability × Neighborhood Density interaction with variation across groups. Specifically, the optimal conditions for typically developing children were rare phonotactic probability with sparse neighborhoods and common phonotactic probability with dense neighborhoods. In contrast, only rare phonotactic probability with sparse neighborhoods was optimal for children with phonological delays.ConclusionsRare sound sequences and sparse neighborhoods may facilitate triggering of word learning for typically developing children and children with phonological delays. In contrast, common sound sequences and dense neighborhoods may facilitate configuration and engagement for typically developing children but not for children with phonological delays because of their weaker phonological and/or lexical representations.
Uniformly curated signaling pathways reveal tissue-specific cross-talks and support drug target discovery
Authors: Korcsmáros Tamás , Farkas Illés J. , Szalay Máté S. , Rovó Petra , Fazekas Dávid , Spiró Zoltán , Böde Csaba , Lenti Katalin , Vellai Tibor , Csermely Péter 
Published: June 2010

Abstract
Motivation: Signaling pathways control a large variety of cellular processes. However, currently, even within the same database signaling pathways are often curated at different levels of detail. This makes comparative and cross-talk analyses difficult.
Results: We present SignaLink, a database containing eight major signaling pathways from Caenorhabditis elegans, Drosophila melanogaster and humans. Based on 170 review and ∼800 research articles, we have compiled pathways with semi-automatic searches and uniform, well-documented curation rules. We found that in humans any two of the eight pathways can cross-talk. We quantified the possible tissue- and cancer-specific activity of cross-talks and found pathway-specific expression profiles. In addition, we identified 327 proteins relevant for drug target discovery.
Conclusions: We provide a novel resource for comparative and cross-talk analyses of signaling pathways. The identified multi-pathway and tissue-specific cross-talks contribute to the understanding of the signaling complexity in health and disease, and underscore its importance in network-based drug target selection.
Availability: http://SignaLink.org
Contact: csermely@eok.sote.hu
Supplementary information: Supplementary data are available at Bioinformatics online.
Peroxisomal Hydrogen Peroxide Is Coupled to Biotic Defense Responses by ISOCHORISMATE SYNTHASE1 in a Daylength-Related Manner
Authors: Chaouch Sejir , Queval Guillaume , Vanderauwera Sandy , Mhamdi Amna , Vandorpe Michaël , Langlois-Meurinne Mathilde , Van Breusegem Frank , Saindrenan Patrick , Noctor Graham 
Published: June 2010

Abstract
While it is well established that reactive oxygen species can induce cell death, intracellularly generated oxidative stress does not induce lesions in the Arabidopsis (Arabidopsis thaliana) photorespiratory mutant cat2 when plants are grown in short days (SD). One interpretation of this observation is that a function necessary to couple peroxisomal hydrogen peroxide (H2O2)-triggered oxidative stress to cell death is only operative in long days (LD). Like lesion formation, pathogenesis-related genes and camalexin were only induced in cat2 in LD, despite less severe intracellular redox perturbation compared with SD. Lesion formation triggered by peroxisomal H2O2 was modified by introducing secondary mutations into the cat2 background and was completely absent in cat2 sid2 double mutants, in which ISOCHORISMATE SYNTHASE1 (ICS1) activity is defective. In addition to H2O2-induced salicylic acid (SA) accumulation, the sid2 mutation in ICS1 abolished a range of LD-dependent pathogen responses in cat2, while supplementation of cat2 with SA in SD activated these responses. Nontargeted transcript and metabolite profiling identified clusters of genes and small molecules associated with the daylength-dependent ICS1-mediated relay of H2O2 signaling. The effect of oxidative stress in cat2 on resistance to biotic challenge was dependent on both growth daylength and ICS1. We conclude that (1) lesions induced by intracellular oxidative stress originating in the peroxisomes can be genetically reverted; (2) the isochorismate pathway of SA synthesis couples intracellular oxidative stress to cell death and associated disease resistance responses; and (3) camalexin accumulation was strictly dependent on the simultaneous presence of both H2O2 and SA signals.
Biochemical and Immunocytological Characterizations of Arabidopsis Pollen Tube Cell Wall
Authors: Dardelle Flavien , Lehner Arnaud , Ramdani Yasmina , Bardor Muriel , Lerouge Patrice , Driouich Azeddine , Mollet Jean-Claude 
Published: June 2010

Abstract
During plant sexual reproduction, pollen germination and tube growth require development under tight spatial and temporal control for the proper delivery of the sperm cells to the ovules. Pollen tubes are fast growing tip-polarized cells able to perceive multiple guiding signals emitted by the female organ. Adhesion of pollen tubes via cell wall molecules may be part of the battery of signals. In order to study these processes, we investigated the cell wall characteristics of in vitro-grown Arabidopsis (Arabidopsis thaliana) pollen tubes using a combination of immunocytochemical and biochemical techniques. Results showed a well-defined localization of cell wall epitopes. Low esterified homogalacturonan epitopes were found mostly in the pollen tube wall back from the tip. Xyloglucan and arabinan from rhamnogalacturonan I epitopes were detected along the entire tube within the two wall layers and the outer wall layer, respectively. In contrast, highly esterified homogalacturonan and arabinogalactan protein epitopes were found associated predominantly with the tip region. Chemical analysis of the pollen tube cell wall revealed an important content of arabinosyl residues (43%) originating mostly from (1→5)-α-l-arabinan, the side chains of rhamnogalacturonan I. Finally, matrix-assisted laser desorption ionization time-of-flight mass spectrometry analysis of endo-glucanase-sensitive xyloglucan showed mass spectra with two dominant oligosaccharides (XLXG/XXLG and XXFG), both being mono O-acetylated, and accounting for over 68% of the total ion signals. These findings demonstrate that the Arabidopsis pollen tube wall has its own characteristics compared with other cell types in the Arabidopsis sporophyte. These structural features are discussed in terms of pollen tube cell wall biosynthesis and growth dynamics.
An mRNA Blueprint for C4 Photosynthesis Derived from Comparative Transcriptomics of Closely Related C3 and C4 Species
Authors: Bräutigam Andrea , Kajala Kaisa , Wullenweber Julia , Sommer Manuel , Gagneul David , Weber Katrin L. , Carr Kevin M. , Gowik Udo , Maß Janina , Lercher Martin J. , Westhoff Peter , Hibberd Julian M. , Weber Andreas P.M. 
Published: June 2010

Abstract
C4 photosynthesis involves alterations to the biochemistry, cell biology, and development of leaves. Together, these modifications increase the efficiency of photosynthesis, and despite the apparent complexity of the pathway, it has evolved at least 45 times independently within the angiosperms. To provide insight into the extent to which gene expression is altered between C3 and C4 leaves, and to identify candidates associated with the C4 pathway, we used massively parallel mRNA sequencing of closely related C3 (Cleome spinosa) and C4 (Cleome gynandra) species. Gene annotation was facilitated by the phylogenetic proximity of Cleome and Arabidopsis (Arabidopsis thaliana). Up to 603 transcripts differ in abundance between these C3 and C4 leaves. These include 17 transcription factors, putative transport proteins, as well as genes that in Arabidopsis are implicated in chloroplast movement and expansion, plasmodesmatal connectivity, and cell wall modification. These are all characteristics known to alter in a C4 leaf but that previously had remained undefined at the molecular level. We also document large shifts in overall transcription profiles for selected functional classes. Our approach defines the extent to which transcript abundance in these C3 and C4 leaves differs, provides a blueprint for the NAD-malic enzyme C4 pathway operating in a dicotyledon, and furthermore identifies potential regulators. We anticipate that comparative transcriptomics of closely related species will provide deep insight into the evolution of other complex traits.
EOBII, a Gene Encoding a Flower-Specific Regulator of Phenylpropanoid Volatiles' Biosynthesis in Petunia
Authors: Spitzer-Rimon Ben , Marhevka Elena , Barkai Oren , Marton Ira , Edelbaum Orit , Masci Tania , Prathapani Naveen-Kumar , Shklarman Elena , Ovadis Marianna , Vainstein Alexander 
Published: June 2010

Abstract
Floral scent, which is determined by a complex mixture of low molecular weight volatile molecules, plays a major role in the plant's life cycle. Phenylpropanoid volatiles are the main determinants of floral scent in petunia (Petunia hybrida). A screen using virus-induced gene silencing for regulators of scent production in petunia flowers yielded a novel R2R3-MYB–like regulatory factor of phenylpropanoid volatile biosynthesis, EMISSION OF BENZENOIDS II (EOBII). This factor was localized to the nucleus and its expression was found to be flower specific and temporally and spatially associated with scent production/emission. Suppression of EOBII expression led to significant reduction in the levels of volatiles accumulating in and emitted by flowers, such as benzaldehyde, phenylethyl alcohol, benzylbenzoate, and isoeugenol. Up/downregulation of EOBII affected transcript levels of several biosynthetic floral scent-related genes encoding enzymes from the phenylpropanoid pathway that are directly involved in the production of these volatiles and enzymes from the shikimate pathway that determine substrate availability. Due to its coordinated wide-ranging effect on the production of floral volatiles, and its lack of effect on anthocyanin production, a central regulatory role is proposed for EOBII in the biosynthesis of phenylpropanoid volatiles.
The Deubiquitinating Enzyme AMSH3 Is Required for Intracellular Trafficking and Vacuole Biogenesis inArabidopsis thaliana
Authors: Isono Erika , Katsiarimpa Anthi , Müller Isabel Karin , Anzenberger Franziska , Stierhof York-Dieter , Geldner Niko , Chory Joanne , Schwechheimer Claus 
Published: June 2010

AbstractUbiquitination, deubiquitination, and the formation of specific ubiquitin chain topologies have been implicated in various cellular processes. Little is known, however, about the role of ubiquitin in the development of cellular organelles. Here, we identify and characterize the deubiquitinating enzyme AMSH3 from Arabidopsis thaliana. AMSH3 hydrolyzes K48- and K63-linked ubiquitin chains in vitro and accumulates both ubiquitin chain types in vivo. amsh3 mutants fail to form a central lytic vacuole, accumulate autophagosomes, and mis-sort vacuolar protein cargo to the intercellular space. Furthermore, AMSH3 is required for efficient endocytosis of the styryl dye FM4-64 and the auxin efflux facilitator PIN2. We thus present evidence for a role of deubiquitination in intracellular trafficking and vacuole biogenesis.
Application of oil‐in‐water emulsion in hot rolling process of brass sheet
Authors: Hu Xianguo , Wang Yourong , Jing Hefeng 
Published: June 2010

PurposeThe purpose of this paper is to develop a new oil‐in‐water (O/W) emulsion used for alpha phase brass, which can increase the antiwear and anti‐galling abilities of the rollers, and improve the surface quality of the rolled brass sheet. The aim is to evaluate the tribological performance of new kind of O/W emulsion for the hot rolling of alpha brass, which provides the fundamental information for the selecting of new chemical group, and to understand the lubrication mechanism of the used rolling emulsion and to correlate the laboratory findings with those of industrial rolling of alpha phase brass.Design/methodology/approachAccording to the hydrophile‐lipophile balance theory and the evaluation results of friction, wear and lubrication using a four‐ball tribometer, a novel O/W emulsion was developed for the hot rolling process of CuZn32(ASTM C26200) and CuZn30(ASTM C26000) alloys by controlling the composition of the emulsion, such as emulsifying, antiwear, extreme pressure, antirust and so on. By scanning electron microscope (SEM), energy‐dispersive X‐ray (EDX), and roughness profile the tribological mechanism were studied.FindingsThe production result proved that it was easy to control the accuracy and size of the brass sheet because of the emulsion‐jet to the roller surface directly and in succession. Polyol with hydroxyl group is found to provide better lubrication and lower coefficient of friction. The actual hot rolling results proved that it was easy to control the accuracy and size of the brass sheet with the emulsion jet. The morphologies and roughness profile of the copper sheet surface were observed and measured by SEM and topographic meter under different lubricant conditions. The in situ results supported the selection of compositions of O/W emulsion. The suitable temperature of feed emulsion is over 20°C.Research limitations/implicationsThe tribological mechanism of friction modified emulsion is not still clear. The thermal mechanical properties of rollers under this kind of emulsion are also worth studying in the future.Practical implicationsUnderstanding the tribological behaviour of O/W emulsion, will be useful for emulsion chemists, tribologists and rolling mill users.Originality/valueThe current study shows new compositions of O/W emulsion used for hot rolling of alpha phase brass.
Thin film elastohydrodynamic lubrication of circular contacts at pure squeeze motion
Authors: Chu Li‐Ming 
Published: June 2010

PurposeThe purpose of this paper is to explore the pure squeeze thin film elastohydrodynamic lubrication (TFEHL) motion of circular contacts with adsorption layers attached to each surface under constant load condition. The proposed model can reasonably calculate the pressure distributions, film thicknesses, normal squeeze velocities, and effective viscosities during the pure squeeze process under thin film lubrication.Design/methodology/approachThe transient modified Reynolds equation is derived in polar coordinates using viscous adsorption theory. The finite difference method and the Gauss‐Seidel iteration method are used to solve the transient modified Reynolds equation, the elasticity deformation equation, load balance equation, and lubricant rheology equations simultaneously.FindingsThe simulation results reveal that the thickness of the adsorption layer and the viscosity ratio significantly influence the lubrication characteristics of the contact conjunction in the thin film regime. In additional, the turning points in the film thickness which distinguish thin film lubrication from elastohydrodynamic lubrication curve is found. In thin film region, the effective viscosity predicted by present model is better than that predicted by traditional elastohydrodynamic theory.Originality/valueThe paper develops a numerical method for general applications with adsorption layers attached to each surface to investigate the pure squeeze action in a TFEHL spherical conjunction under constant load condition.
International human resource management: diversity, issues and challenges
Authors: Scroggins Wesley A. , Benson Philip G. 
Published: June 2010

PurposeThe purpose of this article is to introduce the special issue which considers the impact that the global world has had on the profession of HRM.Design/methodology/approachIn June 2009, the International Human Resource Management Conference was held in Santa Fe, New Mexico, USA. Various IHRM papers were presented, and of these, many were subjected to a second round of reviews for this special issue. This special issue is made up of the best papers.FindingsThe article highlights that as IHRM has emerged as an academic discipline, a variety of debates and issues have come to dominate the literature. For practitioners, a long‐standing issue has been the delineation of specific practices to be used in the management of people within international organizations. Over time, practices have emerged, and texts today can readily be found that represent such practices for those working in MNCs as HR managers.Originality/valueA number of concerns about HRM are raised in this issue, most of which are addressed by the papers chosen.
Modelling and predicting the performance of cross border managers
Authors: Cogin Julie , Fish Alan 
Published: June 2010

PurposeCross border managers are an important feature of the global economy. Despite this, research evidence suggests that the primary selection criteria for cross border managers are technical expertise and domestic business knowledge. This has resulted in insufficient numbers of high calibre candidates to meet the demands of today's global business context. This paper aims to argue that an understanding of an individual's value orientations is important for selecting cross border managers and predicting subsequent performance.Design/methodology/approachThe paper reports the testing of a multidimensional value orientated taxonomy on a sample of 658 managers employed by three multinational organisations. The model was tested via SEM. OLS multiple regression was carried out to identify whether the dimensions of the taxonomy predict the performance of managers in cross border roles.FindingsResults yielded sound factor structure of the taxonomy with a single factor solution identified on each of the two individual value dimensions. SEM confirmed significant relationships and a sound goodness‐of‐fit of the model. OLS regression results indicated that the model accurately predicted the performance of managers during cross border assignments.Research limitations/implicationsSurveys were administered at one point in time and do not account for any change in value orientations.Practical implicationsThe model and results provide guidance to HRM professionals for selecting candidates for cross border business roles.Originality/valueThe study addresses a limitation of earlier work by testing the efficacy of the multi‐dimensional taxonomy with a larger and more diverse sample. The paper evaluates the strength of the taxonomy in predicting performance.
Flex‐time as a moderator of the job stress‐work motivation relationship
Authors: Barney Chet E. , Elias Steven M. 
Published: June 2010

PurposeIt has been known for some time that job stress has a wide‐ranging, negative impact on employees. It has also been known that providing employees with autonomy and/or control over their work environment reduces the deleterious consequences of job stress. The purpose of this study is to examine whether control in the form of flex‐time (i.e. allowing employees to create their own work schedules) moderates the impact of stress on intrinsic and extrinsic motivation among Russian, Canadian, and Israeli Arab employees (n=933).Design/methodology/approachArchival data that was obtained from employees (n=933) residing in three different nations was analysed via hierarchical moderated multiple regression.FindingsIn relation to extrinsic motivation, a significant interaction was observed between job stress, flex‐time, and country of residence. Although flex‐time and country of residence were significant predictors of intrinsic motivation, no significant interactions were observed.Originality/valueThis is one of few papers to examine flex‐time from an international perspective. In terms of value, human resource managers are made aware that the impacts of flex‐time on employees' motivation depends, in part, on the nation in which they are employed.