bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alzheimer's Disease and Small Vessel Disease Differentially Affect White Matter Microstructure
Authors: Tranfa Mario , Lorenzini Luigi , Collij Lyduine E. , Vállez García David , Ingala Silvia , Pontillo Giuseppe , Pieperhoff Leonard , Maranzano Alessio , Wolz Robin , Haller Sven , Blennow Kaj , Frisoni Giovanni , Sudre Carole H. , Chételat Gael , Ewers Michael , Payoux Pierre , Waldman Adam , Martinez‐Lage Pablo , Schwarz Adam J. , Ritchie Craig W. , Wardlaw Joanna M. , Gispert Juan Domingo , Brunetti Arturo , Mutsaerts Henk J. M. M. , Wink Alle Meije , Barkhof Frederik 
Published: May 2024

AbstractObjectiveAlzheimer's disease (AD) and cerebral small vessel disease (cSVD), the two most common causes of dementia, are characterized by white matter (WM) alterations diverging from the physiological changes occurring in healthy aging. Diffusion tensor imaging (DTI) is a valuable tool to quantify WM integrity non‐invasively and identify the determinants of such alterations. Here, we investigated main effects and interactions of AD pathology, APOE‐ε4, cSVD, and cardiovascular risk on spatial patterns of WM alterations in non‐demented older adults.MethodsWithin the prospective European Prevention of Alzheimer's Dementia study, we selected 606 participants (64.9 ± 7.2 years, 376 females) with baseline cerebrospinal fluid samples of amyloid β1‐42 and p‐Tau181 and MRI scans, including DTI scans. Longitudinal scans (mean follow‐up time = 1.3 ± 0.5 years) were obtained in a subset (n = 223). WM integrity was assessed by extracting fractional anisotropy and mean diffusivity in relevant tracts. To identify the determinants of WM disruption, we performed a multimodel inference to identify the best linear mixed‐effects model for each tract.ResultsAD pathology, APOE‐ε4, cSVD burden, and cardiovascular risk were all associated with WM integrity within several tracts. While limbic tracts were mainly impacted by AD pathology and APOE‐ε4, commissural, associative, and projection tract integrity was more related to cSVD burden and cardiovascular risk. AD pathology and cSVD did not show any significant interaction effect.InterpretationOur results suggest that AD pathology and cSVD exert independent and spatially different effects on WM microstructure, supporting the role of DTI in disease monitoring and suggesting independent targets for preventive medicine approaches.
Mismatched Supramolecular Interactions Facilitate the Reprocessing of Super‐Strong and Ultratough Thermoset Elastomers
Authors: Wang Luping , Zhang Kaiqiang , Zhang Xingxue , Tan Yu , Guo Longfei , Xia Yuguo , Wang Xu 
Published: May 2024

AbstractThermoset elastomers have been extensively applied in many fields because of their excellent mechanical strengths and durable characteristics, such as an excellent chemical resistance. However, in the context of environmental issues, the nonrecyclability of thermosets has become a major barrier to the further development of these materials. Here, a well‐tailored strategy is reported to solve this problem by introducing mismatched supramolecular interactions (MMSIs) into a covalently cross‐linked poly(urethane‐urea) network with dynamic acylsemicarbazide moieties. The MMSIs significantly strengthen and toughen the thermoset elastomer by effectively dissipating energy and resisting external stress. In addition, the elastomer recycling efficiency is improved 2.7‐fold due to the superior reversibility of the MMSIs. The optimized thermoset elastomer features outstanding characteristics, including an ultrahigh tensile strength (110.8 MPa), an unprecedented tensile toughness (1245.2 MJ m−3), as well as remarkable resistance to chemical media, creep, and damage. Most importantly, it exhibits an extraordinary multirecyclability, and the 4th recycling efficiency remains close to 100%. This scalable method promotes the development of thermosets with both high performance and excellent recyclability, thereby providing valuable guidance for addressing the issue of nonrecyclability from a molecular design standpoint.
Ambipolar Charge Injection and Bright Light Emission in Hybrid Oxide/Polymer Transistors Doped with Poly(9‐Vinylcarbazole) Based Polyelectrolytes
Authors: Park Yu Jung , Hwang Hee Kyung , Park Yejoo , Lee Ju‐Hyeon , Lee Jin Hee , Walker Bright , Kim Han‐Ki , Seo Jung Hwa 
Published: May 2024

AbstractLight‐emitting transistors (LETs) are a remarkable, emerging class of electronic devices that combine the switching function of field‐effect transistors (FETs) and the light‐emitting function of light‐emitting diodes (LEDs). In order to achieve efficient light emission, effective electron and hole injection from source and drain electrodes is necessary. Various strategies have been introduced to accomplish this, such as incorporating asymmetric electrodes or charge injection layers during device fabrication. These approaches have inevitably introduced complexity in the device fabrication process. Herein, light‐emitting electrochemical transistors (LECTs) are demonstrated that combine principles of electrochemistry and optoelectronics to achieve multi‐functionality in a simple device architecture. Hybrid polyelectrolytes, poly(9‐vinylcarbazolesulfonate)‐ lithium and copper (II) salts (PVK‐Li and PVK‐Cu) incorporating Li+ ion and Cu2+ ions are added at variable concentrations to the organic emitting layer of LECTs to effect electrochemical p‐type doping. This electrochemical doping approach yielded improvements in electrical and optical performances including mobilities, brightnesses, and external quantum efficiency of the LECTs. The dynamics of how charges including ions, electrons, and holes move and interact are discussed in the device to facilitate emissive charge carrier recombination and light emission. This investigation provides valuable insights into the realms of both electrochemistry and optoelectronics.
A PET‐Surrogate Signature for the Interrogation of the Metabolic Status of Breast Cancers
Authors: Confalonieri Stefano , Matoskova Bronislava , Pennisi Rosa , Martino Flavia , De Mario Agnese , Miloro Giorgia , Montani Francesca , Rotta Luca , Ferrari Mahila Esmeralda , Gilardi Laura , Ceci Francesco , Grana Chiara Maria , Rizzuto Rosario , Mammucari Cristina , Di Fiore Pier Paolo , Lanzetti Letizia 
Published: May 2024

AbstractMetabolic alterations in cancers can be exploited for diagnostic, prognostic, and therapeutic purposes. This is exemplified by 18F‐fluorodeoxyglucose (FDG)‐positron emission tomography (FDG‐PET), an imaging tool that relies on enhanced glucose uptake by tumors for diagnosis and staging. By performing transcriptomic analysis of breast cancer (BC) samples from patients stratified by FDG‐PET, a 54‐gene signature (PETsign) is identified that recapitulates FDG uptake. PETsign is independently prognostic of clinical outcome in luminal BCs, the most common and heterogeneous BC molecular subtype, which requires improved stratification criteria to guide therapeutic decision‐making. The prognostic power of PETsign is stable across independent BC cohorts and disease stages including the earliest BC stage, arguing that PETsign is an ab initio metabolic signature. Transcriptomic and metabolomic analysis of BC cells reveals that PETsign predicts enhanced glycolytic dependence and reduced reliance on fatty acid oxidation. Moreover, coamplification of PETsign genes occurs frequently in BC arguing for their causal role in pathogenesis. CXCL8 and EGFR signaling pathways feature strongly in PETsign, and their activation in BC cells causes a shift toward a glycolytic phenotype. Thus, PETsign serves as a molecular surrogate for FDG‐PET that could inform clinical management strategies for BC patients.
Tin Oxide/Amphiphilic Polymer Double‐Layered Hole Transporter for High‐Efficiency Tin Perovskite Solar Modules
Authors: Chiang Chien‐Hung , Chen Hung‐Tse , Chen Wun‐Yu , Wang Wei‐Ting , Feng Shien‐Ping , Wu Chun‐Guey 
Published: May 2024

AbstractAn exquisite, engineering of two poor hole transporting materials (HTMs, SnO, and PDTON) to form an excellent double‐layered HTL (SnO/PDTON) for inverted tin‐perovskite solar modules (TPSMs) is developed. SnO/PDTON has better photovoltaic performance than the commonly used PEDOT:PSS HTM when large‐area TPSMs are fabricated. Thermally evaporated SnO (that is a simple, available oxide with high hole mobility, good transparency, and adjustable frontier orbitals energy levels) film is used as a main hole transporting layer (HTL). Amphiphilic polymer PDTON (having the amine and ether groups on the side chains) film is used as a Co‐HTL, cross‐linker, passivator, and interface modification agent, as unveiled various physicochemical studies. Double‐layered SnO/PDTON with a flat morphology and good affinity toward perovskite precursor solution creates also a proper surface for depositing large‐area, high‐quality TPsk film. Therefore, TPSM (25.2 cm2 active area on 10 cm × 10 cm ITO substrate) based on double‐layered SnO/PDTON HTL achieving an efficiency over 10% with a negligible current hysteresis is reported for the first time. This study emphasizes not only the exquisite design of combining the specific characteristics of two prosaic HTMs to become a good double‐layered HTL but also gives a direction toward fabricating TPSMs to be applied in all‐perovskite tandem solar module.
Technological frontier in Uruguay's beef cattle production: An analysis of technical efficiency and its main drivers
Authors: Aguirre Emilio , García Suárez Federico , Sicilia Gabriela 
Published: May 2024

AbstractGlobally, livestock grazing is a major land occupier and is often criticized for its environmental impact. To address these concerns, enhancing livestock productivity is crucial to mitigate these impacts, boost farm competitiveness, and increase food production. The understanding of production variability is key to this endeavor. This paper assesses the technical efficiency of cow‐calf beef production units in Uruguay, excluding dairy and feedlot operations. Using data from the 2016 National Livestock Survey and Wang's frontier model, we estimate a translog stochastic production frontier, incorporating bovine livestock units, land area, and equivalent working units as key inputs. This model also controls soil productivity, improved grazing areas, productive orientation (beef‐cattle systems or beef cattle‐ovine mixed systems), beef production system (cow‐calf, full cycle, and fattening operation), access to electric power, and agroecological regions. Furthermore, it explores factors affecting technical inefficiency, such as ownership (individual, corporate without contract, and corporate with contract) and land tenure types (owner, tenant, or other types), besides the presence of third‐party owned cattle, technical assistance (including veterinarian and agronomic), and specific beef cattle technologies (such as continuous bull presence, artificial insemination, ovarian activity diagnosis, pregnancy diagnosis, use of scales for classifying females, temporary and early weaning, and cows and heifers grazing together). Findings indicate an average technical efficiency of 71.3%. Notably, factors such as agronomic and veterinary assistance, artificial insemination, weaning practices, third‐party‐owned cattle presence, pregnancy diagnosis, land tenure, and ownership type significantly impact technical efficiency. Our findings suggest that within the specific segment of cow‐calf operations in Uruguay, there is a potential to enhance beef production by 40.2% through improvements in farm management. [EconLit Citations: Q12, D24].
A Hydroxylamine‐Mediated Amidination of Lysine Residues That Retains the Protein's Positive Charge
Authors: He Pei‐Yang , Zhou Yusai , Chen Pu‐Guang , Zhang Meng‐Qian , Hu Jin‐Jian , Lim Yeh‐Jun , Zhang Hongjie , Liu Kai , Li Yan‐Mei 
Published: May 2024

AbstractLysine‐specific peptide and protein modification strategies are widely used to study charge‐related functions and applications. However, these strategies often result in the loss of the positive charge on lysine, significantly impacting the charge‐related properties of proteins. Herein, we report a strategy to preserve the positive charge and selectively convert amines in lysine side chains to amidines using nitriles and hydroxylamine under aqueous conditions. Various unprotected peptides and proteins were successfully modified with a high conversion rate. Moreover, the reactive amidine moiety and derived modification site enable subsequent secondary modifications. Notably, positive charges were retained during the modification. Therefore, positive charge‐related protein properties, such as liquid‐liquid phase separation behaviour of α‐synuclein, were not affected. This strategy was subsequently applied to a lysine rich protein to develop an amidine‐containing coacervate DNA complex with outstanding mechanical properties. Overall, our innovative strategy provides a new avenue to explore the characteristics of positively charged proteins.
Unimolecular Chemiexcited Oxygenation of Pathogenic Amyloids
Authors: Umeda Hiroki , Suda Kayo , Yokogawa Daisuke , Azumaya Yuto , Kitada Nobuo , Maki Shojiro A. , Kawashima Shigehiro A. , Mitsunuma Harunobu , Yamanashi Yuki , Kanai Motomu 
Published: May 2024

AbstractPathogenic protein aggregates, called amyloids, are etiologically relevant to various diseases, including neurodegenerative Alzheimer disease. Catalytic photooxygenation of amyloids, such as amyloid‐β (Aβ), reduces their toxicity; however, the requirement for light irradiation may limit its utility in large animals, including humans, due to the low tissue permeability of light. Here, we report that Cypridina luciferin analogs, dmCLA‐Cl and dmCLA‐Br, promoted selective oxygenation of amyloids through chemiexcitation without external light irradiation. Further structural optimization of dmCLA‐Cl led to the identification of a derivative with a polar carboxylate functional group and low cellular toxicity: dmCLA‐Cl‐acid. dmCLA‐Cl‐acid promoted oxygenation of Aβ amyloid and reduced its cellular toxicity without photoirradiation. The chemiexcited oxygenation developed in this study may be an effective approach to neutralizing the toxicity of amyloids, which can accumulate deep inside the body, and treating amyloidosis.
Core‐Alkynylated Fluorescent Flippers: Altered Ultrafast Photophysics to Track Thick Membranes
Authors: Pamungkas Khurnia Krisna Puji , Fureraj Ina , Assies Lea , Sakai Naomi , Mercier Vincent , Chen Xiao‐Xiao , Vauthey Eric , Matile Stefan 
Published: May 2024

AbstractFluorescent flippers have been introduced as small‐molecule probes to image membrane tension in living systems. This study describes the design, synthesis, spectroscopic and imaging properties of flippers that are elongated by one and two alkynes inserted between the push and the pull dithienothiophene domains. The resulting mechanophores combine characteristics of flippers, reporting on physical compression in the ground state, and molecular rotors, reporting on torsional motion in the excited state, to take their photophysics to new level of sophistication. Intensity ratios in broadened excitation bands from differently twisted conformers of core‐alkynylated flippers thus report on mechanical compression. Lifetime boosts from ultrafast excited‐state planarization and lifetime drops from competitive intersystem crossing into triplet states report on viscosity. In standard lipid bilayer membranes, core‐alkynylated flippers are too long for one leaflet and tilt or extend into disordered interleaflet space, which preserves rotor‐like torsional disorder and thus weak, blue‐shifted fluorescence. Flipper‐like planarization occurs only in highly ordered membranes of matching leaflet thickness, where they light up and selectively report on these thick membranes with red‐shifted, sharpened excitation maxima, high intensity and long lifetime.
Cobaltaelectro‐Catalyzed C–H Activation for Central and Axial Double Enantio‐Induction
Authors: von Münchow Tristan , Liu Yi‐Ru , Parmar Rahul , Peters Sven Erik , Trienes Sven , Ackermann Lutz 
Published: May 2024

AbstractIn recent years, enantioselective electrocatalysis has surfaced as an increasingly‐effective platform for sustainable molecular synthesis. Despite indisputable progress, strategies that allow the control of two distinct stereogenic elements with high selectivity remain elusive. In contrast, we, herein, describe electrochemical cobalt‐catalyzed C−H activations that enable the installation of chiral stereogenic centers along with a chiral axis with high levels of enantio‐ and diastereoselectivities. The developed electrocatalysis strategy allowed for C−H/N−H activations/annulations with cyclic and non‐cyclic alkenes providing expedient access to various central as well as atropo‐chiral dihydroisoquinolinones paired to the valuable hydrogen evolution reaction. Studies on the atropo‐stability of the obtained compounds demonstrated that the exceedingly mild conditions ensured by the electrocatalytic process were key for the achieved high stereoselectivities.
Borderline personality disorder: a symptom of the family system
Authors: Palombi Martina 
Published: May 2024

AbstractThe present article explores the Bowen family systems theory (BFST) view that a mental disorder such as borderline personality disorder (BPD) is not a dysfunction occurring within an individual but a maladjustment of the family emotional system. A case study is presented illustrating how the emotional process moves between individuals within a family system so that when relationship processes become severely compromised, one member absorbs more of the stress, becoming vulnerable to acute symptoms. It is proposed that the use of a BFST approach with a client presenting with panic anxiety and low mood may have contributed to the lowering of symptom intensity for a sibling of the client. It appears that the client's work on her part in the relationship disturbances between her, her mother, father, and sister contributed to decreasing BPD symptoms in her sister and an improvement in overall family functioning. Therefore, the differentiating effort of one family member seemed to have a ripple effect on the whole family system. Shifting the theoretical lens from an individual‐medico‐diagnostic one to a BFST one sheds light on how all family members are expressions of a family organism and players in the symptoms emerging in one.
Preparation of MOR/P(S‐co‐VPh) nanofiber composite membrane and its adsorption properties for rubidium ions
Authors: Fei Pengfei , Shi Qiang , Wang Yi , Sun Xiufang , Shen Yi , Zhang Zhiguo 
Published: May 2024

AbstractRubidium (Rb), a rare and precious metal, is widely used in high‐tech fields. In this work the structural advantages of mordenite (MOR) and group affinity of phenolic hydroxyl polymers (poly (styrene‐4‐hydroxystyrene) (P(S‐co‐VPh)) are combined to prepare MOR/P(S‐co‐VPh) nanofiber composite membranes with high selectivity and adsorption specificity for Rb+ by electrospinning. The test results show that MOR is successfully anchored on the nanofiber substrate and maintained its complete crystal structure. Adsorption experiments show that the adsorption capacity of Rb+ increases with the increase of MOR content, and pH = 9.0, T = 25°C are the best adsorption conditions. K+ shows the most obvious interference with the adsorption capacity decreased from 60.03 to 39.33 mg/g. The adsorption process follows with the Langmuir isothermal model and pseudo‐second‐order kinetic equation. The chemical adsorption based on the coordination reaction is the control step, and the intraparticle diffusion also has an important effect on the adsorption rate. The recycling test indicates that the prepared nanofiber composite membrane not only has efficient adsorption of Rb+, but also exhibits excellent regeneration and stability, which helps to achieve its widespread application and long‐term operation in harsh environments.
Bioinspired chitin/gelatin composites with enhanced mechanical property
Authors: Wang Chong , Xie Xiuling , Chen Zheng , Fang Luxin , Lu Ang 
Published: May 2024

AbstractThe defensive tissues such as insect epidermis and crustacean exoskeleton in nature displayed characteristics of high strength and high toughness via multi‐level structure, which shed light on the designation of natural polymer‐based composites with enhanced mechanical property. Herein, a bioinspired strategy was used to prepare chitin/gelatin composite with improved mechanical property. Chitin hydrogels were first prepared by dissolution in NaOH/urea via freezing–thawing and then regeneration in sodium propionate, to form a heterogeneous nanofibrous structure. After coating gelatin on the chitin nanofibers, a hierarchical structure was obtained, leading to more compact and homogenous morphology. The coating process significantly strengthened the chitin nanofibrous structure and reduced the weak defect, which enhanced the tensile strength and toughness of the composite. The present work not only supplies a chitin/gelatin composite with high mechanical property but also offers a facile approach to prepare strengthening and toughening materials based on natural polymers.
Droplet microfluidics for single‐molecule and single‐cell analysis in research, diagnosis, and therapy
Authors: Sanchez Barea Joel , Kang Dong‐Ku 
Published: May 2024

AbstractDuring the last decade, molecular diagnostics has become increasingly important, especially during the SARS‐CoV‐2 pandemic. Advances in droplet‐based microfluidics, which divides samples into thousands of microdroplets, are responsible for high‐throughput data provision, increased analysis sensitivity, and improved performance to overcome challenges in controlling diseases and early diagnosis. Different targets, such as nucleic acids, proteins, or single cells, can be detected and analyzed in terms of their characteristics in a much more extensive and precise manner with the integration of droplet microfluidics into various molecular diagnostic techniques. In this review, we explore recent advances in the development of droplet microfluidics‐based molecular diagnostic techniques and future perspectives in the field.
Navigating the impact: A comprehensive analysis of ESG disclosure consequences through systematic review
Authors: Li Li , Saat Maisarah Mohamed , Khatib Saleh F. A. , Chu Ping , Sulimany Hamid Ghazi H 
Published: May 2024

AbstractThe purpose of this article is to provide a comprehensive and systematic assessment of the literature on the consequences of environmental, social, and governance (ESG) disclosure by means of content analyses. Using a systematic approach, a sample of 165 studies was collected from the Web of Science database and evaluated on the basis of econometric and content analyses, including publication trends, geographical distribution, theories and consequence associated with ESG disclosure (investment and innovation of firms, financing cost and method, operations and financial risk of firms, firm performance and value and others), provides some direction for future investigation. According to the analysis, the literature was more interested in the stakeholder theory when examining the effects of ESG disclosure on areas including company innovation and investment, financing costs and methods, financial risk and operations, business performance, and others. Even though most of the literature has focused on firm performance and value, there is still no clear understanding of the relationship. Also, limited work was found on the investment and innovation of firms, and financing cost and method, while the impact of operations and financial risk of firms has yet to be explored. Meanwhile, this study also identified the impact of ESG disclosure on analysts, audit fees, and earnings management as a new research direction. Finally, this study innovates new findings that institutional pressures may have an impact on the consequences of ESG disclosure, a topic not found in previous studies.