bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knockdown of TOP2A suppresses IL‐17 signaling pathway and alleviates the progression of ulcerative colitis
Authors: Li Ou , Li Xuexiao , He Jianping 
Published: April 2024

AbstractBackgroundUlcerative colitis (UC) is a chronic inflammatory disease of the colonic mucosa, with a gradually increasing incidence. Therefore, it is necessary to actively seek targets for the treatment of UC.MethodsCommon differentially expressed genes (DEGs) were screened from two microarray data sets related to UC. Protein−protein interaction network was constructed to find the hub genes. The UC mouse model and cell model were induced by dextran sulfate sodium (DSS). The pathological changes of colon tissue were observed by hematoxylin‐eosin staining. Immunohistochemistry and immunofluorescence were performed to detect the expressions of Ki67 and Claudin‐1. The performance of mice was observed by disease activity index (DAI). The effect of TOP2A on proliferation, inflammation, oxidative stress, and interleukin‐17 (IL‐17) signaling pathway in UC model was measured by cell counting kit‐8, enzyme‐linked immunosorbent assay, and western blot.ResultsThrough bioinformatics analysis, 295 common DEGs were screened, and the hub gene TOP2A was selected. In UC model, there was obvious inflammatory cell infiltration in the colon and less goblet cells, while si‐TOP2A lessened it. More Ki67 positive cells and less Claudin‐1 positive cells were observed in UC model mice. Furthermore, knockdown of TOP2A increased the body weight and colon length of UC mice, while the DAI was decreased. Through in vivo and in vitro experiments, knockdown of TOP2A also inhibited inflammation and IL‐17 signaling pathway, and promoted proliferation in DSS‐induced NCM460 cells.ConclusionKnockdown of TOP2A alleviated the progression of UC by suppressing inflammation and inhibited IL‐17 signaling pathway.
Reading alphabetic and nonalphabetic writing systems: A case study of bilingual teachers' reading processes through eye movement miscue analysis
Authors: Wang Yang , Arslan‐Ari Ismahan , Hao Ling , Hwang Kyungjin 
Published: April 2024

AbstractThis case study investigates the reading processes of two bilingual teachers who speak English as a second language and use different first languages—Mandarin Chinese and Korean. The two participants read researcher‐selected digital texts in English and in their respective first language, retold the texts, and answered comprehension questions about the texts. Their reading aloud and eye movements were recorded for miscue and eye movement analysis. Using Eye Movement Miscue Analysis, the findings showcase the distinctive characteristics of their first‐language and second‐language reading processes. The cross‐linguistic comparison between bilingual reading processes further shows the bilingual participants' similarities and differences in terms of the use of language systems, eye movements, language variations, and image use. This study supports the understanding of non‐Roman alphabetical language speakers' reading process, adds to our understanding of the bilingual reading process, and provides teaching and research implications for bilingual teachers and educators.
Echocardiographic findings and pregnancy outcomes for fetuses with complete closure of the ductus arteriosus
Authors: Liu Lixia , Luo Yingchun , Deng Ying , Liang Yanling , Xie Lulu 
Published: April 2024

AbstractObjectiveWe aimed to analyze the echocardiographic characteristics and pregnancy outcomes for fetuses with premature complete closure of the fetal ductus arteriosus.MethodsA retrospective analysis was performed for eight cases of premature ductus arteriosus closure diagnosed by prenatal ultrasonography in the Hunan Maternal and Child Health Hospital from July 2019 to August 2022, and the characteristics of fetal echocardiography and pregnancy outcomes of the eight cases were analyzed and summarized.ResultsIn all cases, the intima of the ductus arteriosus was thickened and occluded, the ductus arteriosus could be seen with slightly hyperechogenic, and no blood flow signal was found in the ductus arteriosus by Doppler ultrasonography. The right heart was enlarged in seven cases, and the whole heart was enlarged in one case. Tricuspid valve regurgitation was observed to different degrees, of which seven cases were severe and one case was moderate. The pulmonary arteries of eight patients had varying degrees of widening. All eight cases were delivered by cesarean section, and one newborn died after follow‐up. The prognosis of the other newborns was good.ConclusionThe parameters of prenatal echocardiography are helpful for the prognosis of fetuses with premature closure of the ductus arteriosus. Early prenatal detection, close observation, and clinical guidance can be used to select the right time of delivery.
Consumer happiness and sustainable consumption
Authors: Arora Neelika , Gandotra Riya , Dhiman Neeraj 
Published: April 2024

AbstractScholars have paid increasing attention to consumer happiness and sustainable consumption, but their findings have not been subject to a systematic review in a business context. We used the SPAR‐4‐SLR framework to fill this gap. Our content analysis of 36 articles allowed us to identify three principal themes—well‐being beyond consumption, the dilemma of ethical consumption, and consumers’ willingness to pay for sustainability—and pinpoint the relationship between consumer happiness and sustainable consumption. The results show that sustainable consumption leads to consumer happiness, that, consumers are happy to consume less, and that they are willing to pay more for sustainability. The findings, which complement those of previous studies, could be used by marketers to devise strategies that encourage sustainable consumption and satisfy consumers.
Effect of dietary protein source and Saccharina latissima on nutritional and safety characteristics of milk
Authors: Wang Bing , Ormston Sabrina , Płatosz Natalia , Parker Jane K , Qin Nanbing , Humphries David J , Pétursdóttir Ásta H , Halmemies‐Beauchet‐Filleau Anni , Juniper Darren T , Stergiadis Sokratis 
Published: April 2024

AbstractBACKGROUNDWheat distillers' grains (WDG) and seaweeds are recommended as alternative protein sources and enteric methane mitigators in dairy cow diets, respectively, but little is known about their impact on milk quality and safety. In the present study, 16 cows in four 4 × 4 Latin squares were fed isonitrogenous diets (50:50 forage:concentrate ratio), with rapeseed meal (RSM)‐based or WDG‐based concentrate (230 and 205 g kg−1 dry matter) and supplemented with or without Saccharina latissima.RESULTSReplacement of RSM with WDG enhanced milk nutritional profile by decreasing milk atherogenicity (P = 0.002) and thrombogenicity (P = 0.019) indices and the concentrations of the nutritionally undesirable saturated fatty acids – specifically, lauric (P = 0.045), myristic (P = 0.022) and palmitic (P = 0.007) acids. It also increased milk concentrations of the nutritionally beneficial vaccenic (P < 0.001), oleic (P = 0.030), linoleic (P < 0.001), rumenic (P < 0.001) and α‐linolenic (P = 0.012) acids, and total monounsaturated (P = 0.044), polyunsaturated (P < 0.001) and n‐6 (P < 0.001) fatty acids. Feeding Saccharina latissima at 35.7 g per cow per day did not affect the nutritionally relevant milk fatty acids or pose any risk on milk safety, as bromoform concentrations in milk were negligible and unaffected by the dietary treatments. However, it slightly reduced milk concentrations of pantothenate.CONCLUSIONFeeding WDG to dairy cows improved milk fatty acid profiles, by increasing the concentrations of nutritionally beneficial fatty acids and reducing the concentration of nutritionally undesirable saturated fatty acids, while feeding seaweed slightly reduced pantothenate concentrations. However, when considering the current average milk intakes in the population, the milk compositional differences between treatments in this study appear relatively small to have an effect on human health. © 2024 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
A varifocal augmented reality head‐up display using Alvarez freeform lenses
Authors: Liu Yi , Qiu Yuqing , Dong Jiaqi , Yang Bo‐Ru , Qin Zong 
Published: April 2024

AbstractA crucial requirement of augmented reality head‐up displays (AR‐HUDs) is continuously adjustable virtual image distance (VID), which allows adaptation to various depths in road environments and thereby avoids visual fatigue. However, usual varifocal components for near‐eye displays are unavailable because AR‐HUDs require the varifocal component's aperture to be larger than 10 cm. This study considers the Alvarez lenses, which change the optical power by in‐plane sliding two freeform lenses. Under the paraxial assumption, classic Alvarez lenses can create a quadratic wavefront profile, but the large aperture and extensive diopter variation range required by AR‐HUDs lead to significant aberrations. Thus, the classic paraxial Alvarez lens design is extended by co‐optimizing Alvarez lenses with high‐order surface profiles and a primary freeform mirror. Therefore, a novel varifocal AR‐HUD containing Alvarez lenses with apertures larger than 15 cm is proposed. The AR‐HUD generates a varifocal plane whose VID can be continuously adjusted between 2.5 and 7.5 m, and another focal plane with a fixed VID at 7.5 m. In addition, merely one display panel is used for compactness. Finally, an AR‐HUD prototype with a reduced volume of 9.8 L was built. The expected varifocal performance and qualified imaging quality were experimentally verified through the field of view, VID, and image sharpness.
Survival and growth of larval Pallid Sturgeon are improved by a live diet
Authors: Treanor Hilary B. , Guy Christopher S. , Ilgen Jason E. , Sealey Wendy M. , Dove Addison T. , Webb Molly A. H. 
Published: April 2024

Abstract

Objective
Conservation propagation facilities in the upper basin of the Missouri River are currently experiencing inconsistent survival of first-feeding larval Pallid Sturgeon Scaphirhynchus albus among genetic families (i.e., distinct male–female pairings). The inconsistent survival can have unintended negative consequences for genetic representation of Pallid Sturgeon that are returned to the Missouri and Yellowstone rivers. We conducted a laboratory study designed to determine whether a live diet improves survival and growth of first-feeding larval Pallid Sturgeon.

Methods
First-feeding larval Pallid Sturgeon from three distinct genetic families were assigned to one of the following diets: live first instar brine shrimp (Artemia franciscana) nauplii, an Otohime dry diet, a 50–50% combination of Otohime and live first instar brine shrimp nauplii, or food restricted (no food). Mortality was evaluated at the end of each day and at the end of the trial (21 days after the onset of exogenous feeding), and individual weight (g) was measured at the end of the trial.

Result
Pallid Sturgeon larvae that received a live diet (either solely live first instar brine shrimp nauplii or the combined diet) experienced higher survival than larvae that were fed solely Otohime. Furthermore, there was statistical evidence that larvae receiving solely live first instar brine shrimp nauplii were heavier at 21 days postexogenous feeding than larvae that were fed either solely Otohime or the combined diet.

Conclusion
Our results suggest that a live diet can improve survival and growth of first-feeding larval Pallid Sturgeon at conservation propagation facilities.
Examining the Longitudinal Relationship Between Olfactory Dysfunction and Frailty in Community‐Dwelling, older US Adults
Authors: Wang Esther , Wroblewski Kristen E. , McClintock Martha K. , Witt Leah J. , Pinto Jayant M. 
Published: April 2024

AbstractObjectiveOlfactory dysfunction is a “canary in the coalmine” for aging conditions. We evaluated olfactory dysfunction as a biomarker of early frailty in older adults living in the United States.Study DesignProspective, longitudinal, nationally representative study.SettingNational Social Life, Health and Aging Project (NSHAP).MethodsWe examined data from 1061 community‐dwelling older US adults. Odor identification (5‐item Sniffin' Stick) and frailty scores were measured at baseline and 5‐year follow‐up. Multivariate logistic regressions evaluated the association between olfactory dysfunction and frailty at baseline in cross‐section and over time in the transition from robust to prefrail to frail, adjusting for confounding factors measured at baseline.ResultsOlder US adults who were anosmic at baseline were more likely to be frail 5 years later compared to normosmic peers (odds ratio [OR]: 3.83, 95% confidence interval [CI]: 1.10‐13.31, P = .035). Examining changes in frailty stage over time, we found that anosmics were more likely to transition from prefrail to frail over 5 years (OR: 3.25, 95% CI: 1.31‐8.08, P = .011). Interestingly, hyposmics did not show a similar trajectory toward frailty (P > .05). In contrast, olfactory dysfunction was not associated with frailty in cross‐section (OR: 0.90, 95% CI: 0.43‐1.89, P = .787, hyposmia; OR: 0.72, 95% CI: 0.15‐3.35, P = .673, anosmia).ConclusionOlder US adults with anosmia face higher odds of becoming frail over 5 years, especially those in the prefrail stage. Olfactory dysfunction may serve as a surrogate marker for early‐stage neurodegenerative diseases, which are strong contributors to frailty.
How the teacher‐student relationship influences adolescents' english academic performance: A multiple mediator analysis based on control‐value theory
Authors: Yu Xiaoqi , Dong Yan , Sun Chunhui , Wang Hongfei , Yang Yuchuan , Yu Guoliang 
Published: April 2024

AbstractThe current study examined a multiple mediator model based on the control‐value theory. A sample of 433 Chinese junior middle school students participated in questionnaires assessing teacher‐student relationships (TSRs), academic emotions, academic value (AV), and academic self‐efficacy (ASE). English test scores were collected as an indicator of students' English academic performance. The results indicated the following: (a) for academic enjoyment, the TSR has an effect on academic achievement through the chain intermediary of AV and ASE; (b) for academic relaxation, the TSR has an effect on English academic achievement through the single intermediary of academic relaxation and the chain intermediary of AV, ASE, and academic relaxation; (c) for academic anxiety, the TSR has an effect on English academic achievement through the single intermediary of AV, the single intermediary of academic anxiety, and the chain intermediary of AV, ASE, and academic anxiety; (d) for academic boredom, the TSR has an effect on English academic achievement through the single intermediary of academic boredom. These findings enrich the relevant research on the control‐value theory and provide important insights for improving students' English academic achievement.
Electrospinning janus membranes for on‐demand oil/water collection and emulsion separation
Authors: Meng Haitao , Xu Tong , Li Chunping , Bai Jie 
Published: April 2024

AbstractOily water pollution has become one of the most serious water environment issue in worldwide. Membrane that can effectively and efficiently remove different oil pollutions from the complex water environment is still urgently needed. Herein, a Janus membrane with opposite wettability that can separate heavy oil–water and light oil–water mixtures on demand was prepared by using a simple sequential electrospinning and chemical crosslinking method. The membrane could remove oil or water under gravity with a high oil/water flux and excellent separation efficiency. Moreover, the membrane could separate different kinds of oil‐in‐water emulsions under gravity with a high flux of 1184 L m−2 h−1 and a tiny flux loss of 4.4% after a 10‐cycle separation. Owing to its excellent anti‐pollution properties the flux recovery rate of the membrane was still higher than 80% after 150 min of emulsion separation. Additionally, the membrane also displayed the ability to transport liquid unidirectionally, giving whom the capabilities to collect oil underwater or water underoil. This research provides a novel and simple method for producing membranes for a variety of separation applications.
Comparison of porcine versus bovine surfactant in preterm respiratory distress syndrome: Evidence from real‐world data. A multicentre collaboration from Karnataka
Authors: Aradhya Abhishek S. , Ghalige Sharath S. , Madarkar Babu , Pruthvishree Hodali Venkataramananaidu , Venkatagiri Praveen , Urs Prashant , Ngangom Daizy , Rangaiah Sandeep , Kumar Vimal , Harini Chinnaraja , Bansal Arpna , Halkar Maneesha P. 
Published: April 2024

AbstractBackground & ObjectivesPorcine surfactant (200 mg/kg initial dose) seems to be superior to bovine surfactants (100 mg/kg) in respiratory distress syndrome (RDS). There is limited data on the choice of surfactant from the developing world. Logically, using higher doses of porcine surfactant comes with an additional cost burden. We decided to evaluate the clinical effects of different types of surfactants.MethodsA retrospective analysis was conducted from August 2019 to December 2022 in six tertiary centers. Neonates 24–34 weeks of gestation with RDS requiring either porcine (200 mg/kg) or bovine surfactant (100 mg/kg) were enrolled. The proportion of BPD, redosing, and other morbidities in either group were analyzed. The outcomes in preterm ≥28 and <28 weeks subgroups were analyzed.ResultsOf 1149 eligible babies, 302 (26%) received surfactant after stabilization with CPAP. One hundred fifty‐eight received porcine, and 144 received bovine surfactant. There was a higher BPD in porcine compared to the bovine group on univariate analysis [24 (15%) vs. 6 (4%); OR: 4; 95% CI: 1.6–10; p = 0.002]. On logistic regression, the gestational age and PDA requiring treatment were independent predictors of BPD, and the type of surfactant and centres did not influence BPD. Redosing [27 (17%) vs. 18 (12%), OR: 1.4; 95% CI: 0.7–2.7; p = 0.2] was not different between both surfactant types. Other morbidities like mortality, air leaks, invasive ventilation, and CPAP duration were also not different between the groups.ConclusionWe could not find a difference in the outcomes of BPD and redosing using porcine surfactant at 200 mg/kg compared to bovine surfactant. Considering the cost burden in the developing world, efficacy needs to be evaluated in randomized clinical trials.
Survey of target site mutations linked with insecticide resistance in Italian populations of Aphis gossypii
Authors: Cominelli Filippo , Chiesa Olga , Panini Michela , Massimino Cocuzza Giuseppe Eros , Mazzoni Emanuele 
Published: April 2024

AbstractBACKGROUNDAphis gossypii is a worldwide agricultural pest that causes high levels of economic losses by feeding and transmitting virus diseases. It is usually controlled by chemical insecticides, but this could lead to the selection of resistant populations. Several single nucleotide polymorphisms (SNPs) have been identified associated with insecticide resistance. Monitoring activities to detect the presence of such mutations in field populations can have an important role in insect pest management but, currently, no information on Italian strains is available.RESULTSThe presence of target site mutations conferring resistance to different insecticides was analysed in Italian field collected populations of A. gossypii with an allele specific approach (QSGG, Qualitative Sybr‐Green Genotyping). Primers were designed to detect mutations in genes coding acetylcholinesterase (S431F), nicotinic acetylcholine receptor (R81T) and voltage‐gated sodium channel (M918L and L1014F). S431F was widespread but with high variability across populations. R81T was detected for the first time in Italy but only in two populations. The L1014F mutation (kdr) was not found, while in the samples showing the M918L two different nucleotidic substitutions were detected. Mutant allele frequencies were, respectively, 0.70 (S431), 0.31 (M918) and 0.02 (R81). Further analysis on the voltage‐gated sodium channel gene showed the presence of eight haplotypes and one non‐synonymous mutation in the gene coding region.CONCLUSIONMultiple target‐site mutations were detected within Italian populations. The combinations of genotypes observed in certain locations could affect negatively the control of this pest. Preliminary insights on the genetic structure in the Italian populations of A. gossypii were acquired. © 2024 Society of Chemical Industry.
UV‐Induced Oxidation Preparation of Multi‐Functional Lignin‐Based AgNPs and its Application for Conductive Coating, Antibacterial Enhancement, and Product Separation
Authors: Yang Song , Li Shengren , Xue Yuyuan 
Published: April 2024

AbstractThis study presents a novel approach for regulating the properties of lignin‐based silver nanoparticles (AgNPs), which was UV‐induced Tetrahydrofuran (THF) to form peroxide for the etching of these nanoparticles. The lignin coating was first degraded by oxidation, and the properties of the exposed AgNPs changed under etching. Notably, water can greatly regulate the oxidation capacity of the THF medium, thereby controlling the degradation degree of lignin coating and obtaining dissolution, aggregation, precipitation, and color‐variable phenomena of AgNPs under the synergistic effect of UV irradiation and peroxide etching. By adjusting UV irradiation time, various functional products of silver nanowires (AgNWs), color‐variable AgNPs, lignin‐based AgNPs aggregates, and composite solution of Ag particles and Ag+ were obtained. The transformation of these product properties is closely related to the oxidation capacity of H2O/THF medium. In addition, Multi‐functional Lignin‐based AgNPs show excellent application potential in conductive coating, antibacterial enhancement, and product separation, providing a promising avenue for the targeted utilization of lignin‐based AgNPs.
Design and Synthesis of Potent Anticancer Agents Using Coumarin‐Quinazolinone Based Scaffolds: Exploration of ADME Properties and Molecular Docking Studies
Authors: Babagond Vardhaman , Katagi Kariyappa , Akki Mahesh , Reddy Dinesh S. , Shanavaz Hamzad , Jaggal Ashwini , D K Soumyashree 
Published: April 2024

AbstractCancer remains a complex global threat causing widespread deaths. Developing effective anticancer agents despite advancements still remained challenging. In this work it is designed and synthesised therapeutically active anticancer agents based on coumarin‐quinazolinone 5(a–j) through nucleophilic substitution reaction of 4‐bromomethyl coumarin derivatives with 6,7‐bis(2‐methoxyethoxy)quinazolin‐4(3H)‐one and characterised by using FTIR, 1HNMR, 13C NMR and LCMS analysis. The compounds 5(a–j) were screened for in vitro anticancer activity against A‐549 lung cancer cell lines and MDA‐MB‐231 cell lines. Compound 5i emerged as the most promising antiproliferative candidate demonstrating an IC50 value of 7.11 μM against A‐549 cell lines. Meanwhile compound 5g found as a hit candidate in the case of MDA‐MB‐231, exhibiting an IC50 of 5.12 μM, surpassing the potency of the standard drug doxorubicin (IC50 5.89 μM). Further, the safety profile of coumarin‐quinazolinone scafolds (5a–j) were examined for their cytotoxicity towards human embryonic kidney cell lines (HEK293). It was found that the most active compounds exhibited good safety profile towards human embryonic cell lines. Additionally, molecular docking investigations confirmed that compounds 5(a–j) exhibited elevated docking scores and demonstrated favourable interactions with the HER2 (PDB:3PP0) and VEGFR2 (PDB:4ASE). Furthermore, we investigated the ADME properties using the SwissADME tool.