bluuebunny/crossref_metadata_2025_split huggingface dataset:
Embracing Levin's Legacy: Advancing Socio-Technical Learning and Development in Human-Robot Team Design through Action Research and STS Approaches
Authors: Ang Karyne , Sankaran Shankar , Liu Dikai 
Published: June 2024

Abstract

This paper investigates the synergy between Levin's theories on technology transfer as a socio-technical learning and developmental process (TLD process), action research, and sociotechnical systems (STS) theories. Levin's extensive work highlights the significance of technology transfer as a means for organizational development. His TLD process emphasizes the intricate interplay between technology, organizational change, and learning and highlights the importance of incorporating cultural knowledge and skills into the technological transfer process. Contemporary STS views are introduced to complement and extend Levin's theories by providing a systemic lens to understand the broader socio-technical context in which technology transfer occurs. To illustrate the synergies and potential challenges from Levin’s theories of technology transfer with contemporary STS concepts, we use a qualitative study of a unique case about the design and development of human-robot teams (HRTs) for construction tasks. Our findings reveal that while Levin's theories provide a valuable foundation for understanding technology transfer and organizational change, contemporary sociotechnical systems face unique challenges in the context of AI-driven human-robot teams where intelligent robots also contribute to the sociotechnical learning. Moreover, the rapidly evolving nature of technology and innovations could exponentially impact on multidisciplinary design teams, stakeholder participation and inter-organizational dynamics. The discussions suggest an extension of co-generative learning to incorporate of ‘collaborative intelligence’ between human-robot teams enabled by AI. Consequently, Levin's theories of technology transfer might not fully address the complex ethical dilemmas caused by AI-driven HRT systems. Therefore addressing these challenges requires ongoing dialogue and collaboration among researchers, practitioners, and policymakers with different disciplinary backgrounds to develop robust and reliable sociotechnical systems frameworks to navigate the complexities of robotics and AI in today's rapidly evolving technological landscape.
Accurately predicting optimal conditions for microorganism proteins through geometric graph learning and language model
Authors: Yang Yuedong , Zhu Mingming , Song Yidong , Yuan Qianmu 
Published: June 2024

Abstract

Proteins derived from microorganisms that survive in the harshest environments on Earth have stable activity under extreme conditions, providing rich resources for industrial applications and enzyme engineering. Due to the time-consuming nature of experimental determinations, it is imperative to develop computational models for fast and accurate prediction of protein optimal conditions. Previous studies were limited by the scarcity of data and the neglect of protein structures. To solve these problems, we construct an up-to-date dataset with more than 6 million proteins and propose GeoPoc based on geometric graph learning for the protein optimal temperature, pH, and salt concentration prediction. GeoPoc leverages protein structures and sequence embeddings extracted from pre-trained language model, and further employs a geometric graph transformer network to capture the sequence and spatial information. We first focused on in-house validation for optimal temperature prediction for robustness assessment, and achieved a PCC of 0.77. The algorithm is further confirmed in an independent test set, where GeoPoc surpasses the state-of-the-art method by 2.3\% in AUC. Additionally, GeoPoc was extended to pH and salt concentration prediction, and obtained AUC scores of 0.78 and 0.77, respectively. Through further interpretable analysis, GeoPoc elucidates the critical physicochemical properties that contribute to enhancing protein thermostability.
The impact of the multicomponent “Healthy and Vital” 3-month lifestyle intervention in health professionals: a single group pre-(multiple) post-study.
Authors: Boelens Mirte , Jong Jessica C. Kiefte-de , Schweitzer Dave H. , Elsgeest Liset E.M. , Mimpen Sytian , Hilders Carina G. J. M. 
Published: June 2024

Abstract

Background
Working in healthcare often involves stressful situations and a high workload, and many healthcare workers experience burnout complaints or suffer from mental or physical problems. This also affects the overall quality of health care. Many previous workplace interventions focused on knowledge exchange instead of other health cognitions, and were not particularly effective. Multicomponent lifestyle interventions may offer the potential in improving lifestyle and well-being of healthcare professionals. This study aims to evaluate the impact of a multicomponent lifestyle intervention “Healthy & Vital” for healthcare professionals on several health-related outcomes.
Methods A pre- (multiple) post-pilot study has been conducted using data from 2012-2018 to evaluate the lifestyle intervention in 126 female healthcare professionals. Measurements were conducted before, directly after the intervention (at 3 months), and 6 months after finishing the intervention (at 9 months). Participants filled out questionnaires and anthropometrics measurements were conducted by a dietitian. The intervention is based on the ASE-model, theory of planned behavior, and motivational interviewing techniques. The intervention included workshops related to stress, eating, sleep, and individual meetings with a dietitian. Multilevel linear mixed models with a random intercept and fixed slope were used to evaluate the impact on lifestyle self-efficacy, eating behavior, anthropometric outcomes and quality of life.
Results Improvements were observed for lifestyle self-efficacy (total: beta=1.32 95%CI 0.94;1.48, I know: beta=1.19 95%CI 0.92;1.46, and I can: beta=1.46 95%CI 1.19;1.73), eating behavior (emotional eating: beta=-0.33 95%CI-0.44;-0.23, external eating: beta=-0.35 95%CI -0.44;-0.26, and diet/restrictive behavior: beta=0.41 95%CI 0.30;0.51), anthropometric outcomes (weight: beta=-5.03 95%CI -5.93;-4.12, BMI: beta=-1.873 95%CI -2.06;-1.41, waist circumference: beta=-6.83 95%CI -8.00;-5.65, and body fat percentage: beta=-1.80 95%CI -2.48;-1.17) and multiple outcomes of quality of life (physical functioning: beta=4.43 95%CI 1.98;6.88, vitality: beta=7.58 95%CI 4.74;10.42, pain: beta 4.59 95%CI 0.91;1.827, general health perception: beta=7.43 95%CI 4.79;10.07, and health change: beta=21.60 95%CI 16.41;28.80) directly after the intervention. The improvements remained after a six-month follow-up.
Conclusions Multicomponent interventions such as “Healthy and Vital” for healthcare professionals may be useful for improving the health of healthcare workers. More research using other designs with a control group, such as a stepped-wedge or RCT, is needed to verify our findings.
Trial registration: Retrospectively registered on May 1 2024 at the Open Science Framework Registries (https://doi.org/10.17605/OSF.IO/Z9VU5)
Tracking Over 30 Years of Coral Reef Infrastructure Degradation in Barbados
Authors: Griffith Aliyah , Castillo Karl , Lee Sandra , Buglisi Max 
Published: June 2024

Abstract

Coral reefs face escalating threats from global and local stressors, with climate change exacerbating these challenges in the Caribbean. This study focuses on coral reef infrastructure in Barbados, where Lewis (2002) documented reef degradation in the 1990s. As 30 years have passed, we chose to determine the rate of change of reef infrastructure and quantify associated substrate presence along the western reefs of Barbados. Using satellite and geotagged imagery, we analyzed 19 reef structures from 2013 to 2023 along the western coast of Barbados, comparing them to Lewis's findings in 1950 and 1991. We also ground-truthed five sites previously categorized as highly degraded reefs to confirm reef structural integrity and substrate-type presence. We confirmed ongoing structural loss, averaging ~146.9 m2 annually across all sites. We identified four primary substrate types: coral, algae-covered substrate, rubble, and sand, with algae-covered substrate predominating and projected to persist. Our results underscore the urgency of monitoring and highlight the potential limitations of satellite assessment. This research enhances understanding of reef dynamics and offers a framework for identifying vulnerable areas, which are crucial for effective conservation efforts.
The mediating role of social support on self-management and quality of life in cirrhotic patients
Authors: Zhang Ying , Xiao LeYao , Liu Qian , Zhang XinYi , Li MingDan , Xu YaLi , Dai Mei , Zhao Fei , Shen YouShu , Salvador Jordan Tovera , Yang Ping 
Published: June 2024

Abstract

Background
Insufficient social support is linked to patients' inability to manage their chronic illnesses on their own, and cirrhosis patients are frequently related with malnourishment and physical inactivity that lowers their quality of life. Thus, the purpose of this study was to examine the potential mediating function of social support in the relationship between self-management and quality of life, as well as the impact of exercise frequency and malnutrition risk assessment on these variables.
Methods
Convenience sampling was used to select cross-sectional data from 257 liver cirrhosis patients who visited the infection department of a tertiary hospital using in Zunyi City between 2021 and 2022. The Chronic Liver Disease Questionnaire (CLDQ), the Nutritional Risk Screening Tool (RFH-NPT), the Social Support Scale (SSRS), the Self-Management Behavior Scale for Cirrhotic Patients, and demographic questionnaires were used to evaluate the patients.
Results
（1）Social support and self-management had a positive correlation (r=0.668, 0.665, both P<0.001) with quality of life. (2) Self-management was found to have a direct predictive influence on quality of life by mediation analysis, while social support was found to have a mediating effect between the two variables of 0.489 (95% CI: 0.362,0.629) and 40.58% of the overall effect was accounted for by the indirect effect.
(3) Social support, self-management, and quality of life were all influenced independently by the frequency of exercise and the assessment of malnutrition risk.
(4) After confounders were eliminated from the regression model analysis, Model I accounted 14.5% of the variance in the quality of life control variables, while Model II explained 49.5%. 56.9% of the variation in quality of life was explained by Model III once the social support variable was included.
Conclusions
Quality of life is enhanced by self-management through the mediation of social support. Social support and self-management were additionally moderated by the frequency of exercise and the assessment of nutritional risk, both of which were independent factors. These results imply that patients with cirrhosis may experience an improvement in quality of life from self-management programs designed to strengthen social support.
Implications of sea-level rise on the coastal villages of Kanyakumari District, Tamil Nadu, India: A geospatial perspectives
Authors: Veeran Yoganandan , Swornamma John Bose Rajayan , Balasubramaniyan Monisha 
Published: June 2024

Abstract

It’s a realistic approach with the coastline geometry of the sea level rise by statistical analysis of aerial data and concludes with the coastal elevation effects on the different segments of the coastal regions at the village level in Kanyakumari district in Tamil Nadu, India. The physical responses of the coastal zones to extract the coastal landforms of Kanyakumari, India by the comprehensive analysis of inundation scenarios, can find out the risk factors of relative sea level rise. The study area was encompassed into three taluks (Agastheeswaram, Kalkulam, and Killiyoor) and derived into 17 revenue coastal villages for the Land use /Landover (LU/LC) prepared from the satellite imagery with the digital elevation model, The sea level rise scenarios were generated into four class, such as very high (-2m to 0m), high (0m to 0.5m), moderate (0.5m to 1.0m), and low (1.0m). Among the three taluks in the study area, the Agastheeswaram taluk will be inundated 1132.23 ha (10.76%) of the coastal area and Killiyoor taluk will be inundated 327.99 ha (5.39%) of the coastal area are under immediate risk of 0.5m rise in sea-level. Overall, this study exposed significant increases: more than 17% of the coastal population living in the Low Elevation Coastal Zone of the Kanyakumari coast will be exposed to future sea level inundation.
Clinicopathological significance of CD36 expression in oral squamous cell carcinoma
Authors: Sakurai Kotaro , Tomihara Kei , Yamazaki Manabu , Yamada Shin-ichi 
Published: June 2024

Abstract

CD36, a fatty acid scavenger receptor expressed in tumors, is associated with a poor prognosis in several types of cancers. We previously reported the involvement of CD36 in the proliferation and migration of oral squamous cell carcinoma (OSCC) cells. However, little is known regarding the clinical significance of CD36 expression in OSCC. In the present study, we evaluated the association between CD36 expression and the clinicopathological characteristics of patients with OSCC. Immunohistochemical expression of CD36 was quantified using the H-score, and its association with clinicopathological characteristics was evaluated in 32 OSCC cases. The mean H-score for CD36 expression in the membrane was 83.27. CD36 expression was significantly correlated with the mode of invasion and differentiation of OSCC cells. Moreover, high CD36 expression was significantly correlated with a low survival rate and relapse in patients. Our results suggest that CD36 may be a predictive biomarker for OSCC malignancy and prognosis.
A Social Network Analysis Approach To Organizational İsolation İn Public Schools.
Authors: YARIM Mehmet Ali 
Published: June 2024

Abstract

Background
This study, which aims to examine the causes and consequences of organizational isolation in schools with the help of social network analysis, is included in the embedded explanatory pattern model, which is one of the mixed method models.
Methods
The research was conducted in the 2022–2023 academic year in the center of Erzurum, Turkey, on ten schools selected by purposeful sampling method.
Results
According to the results of the research, while organizational loneliness is not seen in small schools, there are individuals experiencing loneliness in large schools. The main reason for these individuals' loneliness is their social relationships and communication at school. Individuals who become lonely have a negative perception of social relations at school and isolate themselves from school activities and communication. As a result of this situation, negative consequences such as exclusion, burnout, lack of belonging, mobbing and pessimism emerge.
Conclusions
Even if the culture, climate and structure of the school are positive, individuals may experience loneliness. The reason for this is the meaning that individuals attach to social relations at school.
Complement Membrane Attack Complexes Disrupt Proteostasis to Function as Intracellular Alarmins
Authors: Song Guiyu , He Liying , Jiang Quan , Barkestani Mahsa , Wang Shaoxun , Wang Qianxun , Ren Pengwei , Fan Matthew , Johnson Justin , Mullan Clancy , Jane-wit Dan 
Published: June 2024

Abstract

Internalized pools of membrane attack complexes (MACs) promote NF-kB and dysregulated tissue inflammation. Here, we show that C9, a MAC-associated protein, promotes loss of proteostasis to become intrinsically immunogenic. Surface-bound C9 is internalized into Rab5 + endosomes whose intraluminal acidification promotes C9 aggregates. A region within the MACPF/CDC domain of C9 stimulates aggrephagy to induce NF-kB, inflammatory genes, and EC activation. This process requires ZFYVE21, a Rab5 effector, which links LC3A/B on aggresome membranes to RNF34-P62 complexes to mediate C9 aggrephagy. C9 aggregates form in human tissues, C9-associated signaling responses occur in three mouse models, and ZFYVE21 stabilizes RNF34 to promote C9 aggrephagy in vivo. Gene-deficient mice lacking ZFYVE21 in ECs showed reduced MAC-induced tissue injury in a skin model of chronic rejection. While classically defined as cytotoxic effectors, MACs may impair proteostasis, forming aggregates that behave as intracellular alarmins.
Evaluation of groundwater quality and contamination hazardous using water quality index and physicochemical analysis in Assiut governorate, Upper Egypt
Authors: O Nassar W. , Hosny Rasha , Ghareeb Mohammed , Abd-Elhamid Hany F. , Zelenáková Martina , Gad Manal 
Published: June 2024

Abstract

The primary water sources for Egypt are the River of the Nile and groundwater. Evaluating and assessing these vital resources is crucial for responsible usage and meeting the growing demand for water. In Assiut area, groundwater stands as the second most significant freshwater source, serving all sectors including industrial sector, agricultural sector, and lastly domestic sector. Unfortunately, the source of groundwater in Assiut governorate face the imminent threat of contamination, primarily due to agricultural and other activities. A hydrochemical investigation was conducted graphically and spatially within GIS environment in the limestone Eocene aquifer of the designated study area. This research involved the collection and analysis of twelve groundwater samples to realize the physiochemical characteristics, providing insights into the hydrochemistry of the water. The assessment of water quality involved evaluating parameter concentrations and comparing them to drinking water and irrigation standards set by both the Organization of World Health (WHO) and the Egyptian Specifications (ES). These parameters comprise of; Electrical Conductivity (EC), pH, Total Dissolved Solids (TDS), Nitrate (NO3-) and Fluoride (F-). The analysis indicates that the groundwater is not entirely suitable for drinking, particularly concerning TDS, COD, and TOC. In certain samples, the parameters concentrations surpass the allowable limits defined by both WHO and ES. This is due to the increase in domestic and industrial wastewater discharge the stretch, as well as other harmful anthropogenic activities, and human interventions. The findings of this study could help the policymakers to take the suitable action to protect people and animals’ health form contaminated water.
Matched comparative study of 3D printed microporous tantalum prosthesis versus autologous bone graft in the final stage of Masquelet induced membrane surgery
Authors: Yang Yin , Xu Yongqing , Shi Jian , Zhang Hu , He Xiaoqing , Qi Baochuang , Wang Ten , Yu Wei , Li Gang , Fan Xinyu 
Published: June 2024

Abstract

Introduction:
Masquelet induced membrane surgery is a viable option for the reconstruction of extensive bone defects. This study aimed to comprehensively compare the clinical efficacy of 3D printed microporous tantalum prosthesis and autologous bone graft in the final stage of Masquelet induced membrane surgery during the treatment of lower extremity osteomyelitis with large segmental bone defect.
Methods
A prospective analysis was conducted on 43 patients with large segmental bone defect caused by lower extremity osteomyelitis treated with Masquelet induced membrane surgery. Among these, 21 patients were implanted 3D printed microporous tantalum prosthesis (Prosthesis group), while 22 patients were implanted autologous bone graft (Autologous bone group) in the final-stage surgery. Follow-up was conducted for 12 months postoperatively. Clinical efficacy was evaluated using the Paley grade for bone defect healing, Visual analog scale (VAS), Lower extremity functional scale (LEFS), Fernandez-Esteve eschar score, and time to full weight-bearing. The clinical outcomes between the two treatment groups were compared.
Results
Postoperatively, the scores of VAS and LEFS significantly improved compared to preoperative values in both groups (all P < 0.001). Compared to the Autologous bone group, the Prosthesis group demonstrated significantly higher LEFS scores and Fernandez-Esteve eschar scores, along with a significantly shorter time to full weight-bearing (all P < 0.05).
Conclusion
Both implants show remarkable efficacy in the reconstruction of large segmental bone defect caused by lower extremity osteomyelitis. However, 3D printed microporous tantalum prosthesis exhibits certain advantages over the autologous bone graft in terms of limb function recovery, bone callus growth, and early weight-bearing.
Population genomics of eastern oysters, Crassostrea virginica, in a well-mixed estuarine system: advancement and implications for restoration strategies
Authors: Stasse Alyssa , Brown Bonnie L. 
Published: June 2024

Abstract

Eastern oysters, Crassostrea virginica, are historically a keystone species in many of the estuaries in which they reside, providing critical ecosystem services. Because oyster populations have been on the decline, restoration initiatives currently are underway in many estuarine systems including Great Bay Estuary (GBE), New Hampshire. Results of prior studies of eastern oyster population genomics cannot be applied directly to GBE, as it is a well-mixed estuarine system that is relatively contained, and the sources of recruits are split among cultivated and native. This study aimed to identify the population genomic structure of eastern oysters in GBE, to facilitate determination of effective population size and estimation of genetic differentiation among subpopulations. Results showed moderate genomic differentiation among native, cultivated, and restoration C. virginica subpopulations in the Bay. A small number of breeders (Ne=163 – 276) was found in all subpopulations except the Lamprey River site (Ne=995). This research provides a contemporary snapshot of eastern oyster subpopulation structure at the genomic level in GBE that will facilitate restoration and enhanced management.
The efficacy of norepinephrine application in Mammotome-assisted minimally invasive resection for benign breast neoplasm: A retrospective study Running title：norepinephrine application in benign breast neoplasm
Authors: Sun Yafei , Xu Zipeng , Hu Jing , You Lina , Chen Chaobo 
Published: June 2024

Abstract

Objective
Although Mammotome-assisted minimally invasive resection (MAMIR) has been widely accepted for treating breast benign nodules, the procedure remains very technical and challenging. The present study aimed to assess the efficacy of norepinephrine application in MAMIR concerning intraoperative hemorrhage, postoperative pain and postoperative hospitalization.
Methods
A total of 306 patients with breast nodules admitted at the Xishan people’s Hospital of Wuxi City between June 2021 and July 2023 were included in this retrospective cohort study. Univariate and multivariate analyses were performed to estimate the odds ratio (OR) and the 95% confidence intervals (CIs) for outcomes.
Results
A total of 155 who accepted MAMIR were included in this study. Univariable analysis indicated that bilateral nodules, operation time and intraoperative hemorrhage were risk factors for increasing postoperative hospitalization, while the usage of norepinephrine during operation helped to reduce postoperative hospitalization (P < 0.05), but none of them were independent factors influencing postoperative hospitalization according to the multivariable analysis (P > 0.05). Furthermore, multivariate analysis identified the usage of norepinephrine during MAMIR as an independent factor associated with reducing intraoperative hemorrhage (OR = 0.11, 95%CI: 0.05–0.26, P < 0.001) and relieving postoperative pain (OR = 0.02, 95%CI: 0.004–0.08, P < 0.001).
Conclusions
Norepinephrine could help to reduce postoperative hospitalization and intraoperative hemorrhage, also relieve postoperative pain for breast benign nodules resection, which was an independent protective factor for relieving postoperative pain and reducing intraoperative hemorrhage.