bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of appendectomy in Japanese families
Authors: HIRAIWA HISAYUKI , UMEMOTO MASAKAZU , TAKE HIROMICHI 
Published: January 2011

AbstractWe investigated the prevalence of appendectomy in Japan to determine the tendency of familial aggregation on appendicitis using a large scale study. A total of 517 Japanese women (aged 20 to 45 years) served as the subjects and were questioned regarding their family history of appendectomy due to appendicitis. We compared the prevalence of appendectomy in children (subjects + their siblings) of three groups of families: (i) both parents affected; (ii) one parent affected; (iii) no parents affected. The differences between groups were statistically significant using contingency table and Chi‐squared test. Our results suggest that about 40% of children with both parents affected, and about 20% of children with one parent affected may develop the disorder during childhood. This study may provide useful information in the nature of the development of appendicitis.
Cerebrospinal fluid amino acid levels in newborn infants with intracranial hemorrhage
Authors: YURDAKÖK MURAT , COŞKUN TURGAY , ERDEM GÜLŞEN , GÖKTOGAN ŞAFAK , ÖZALP İMRAN , TEKİNALP GÜLSEVİN 
Published: January 2011

AbstractCerebrospinal fluid (CSF) amino acid levels including excitatory amino acids (i.e. glutamate and aspartate) in 25 preterm and 18 full‐term newborn infants with no serious disease except intracranial hemorrhage (ICH) were measured. ICH was detected in 13 preterm and six full‐term infants on the basis of the clinical, lumbar puncture (LP) and cranial ultrasonography (CraUSG) findings. Twelve preterm and 12 full‐term infants who were neurologically healthy comprised the control group. The mean concentration of CSF amino acids did not differ between preterm and full‐term infants. The CSF concentrations of taurine, threonine, glycine, alanine, valine, isoleucine, leucine, tyrosine and phenylalanine in preterm infants, and threonine, aspartic acid and alanine in full‐term infants were significantly elevated in infants with ICH. These abnormalities, especially in preterm infants, are probably related to cerebral hypoxia in CSF amino acid concentrations in newborn infants with ICH.
Hurler syndrome with severe complication in post‐bone marrow transplantation course: Life threatening interstitial pneumonitis and hypertension
Authors: OHASHI TOYA , TAHARA TAKAHIRO , FUJISAWA KOUJI , HOSHI YASUTAKA , ITO FUMIYUKI , SUZUKI NAOKI , ETO YOSHIKATSU , MAEKAWA KIHEI 
Published: January 2011

AbstractBone marrow transplantation (BMT) was performed in a 3 year old patient with Hurler syndrome. The post‐BMT course was complicated by interstitial pneumonitis and severe hypertension, which were life threatening. The patient responded well to therapy and recovered. BMT in this patient resulted in significant clinical improvement in the signs and symptoms of Hurler syndrome. Biochemical improvement, including elevated α‐l‐iduronidase activity in white blood cells and decreased urinary glycosaminoglycan excretion was significant. However, skeletal and neurological impairment were not improved. We conclude that BMT for Hurler syndrome should be performed at an earlier stage, before severe neuronal damage has occurred. Moreover, BMT is a high risk procedure and there will always be a possibility that life threatening complications will occur, as in our case.
Accelerated ventricular rhythm in the newborn
Authors: KUROTOBI SHUNJI , MATSUSHITA TOHRU , TAKEUCHI MAKOTO , KOGAKI SHIGETOYO , SANO TETSUYA , ABE JIRO , OKADA SHINTARO 
Published: January 2011

AbstractAccelerated ventricular rhythm was observed in two newborn infants. Neither of them had any causative clinical symptoms for the ventricular arrhythmia. The arrhythmia disappeared when the infants were 18 days and 45 days old, respectively. Arrhythmia was noted in the fetal period, especially in case 1.
A sex reversal infant with XX karyotype and complete male external genitalia
Authors: NOMURA YOKO , YAGI HIDEKI , ONIGATA KAZUMICHI , YUTANI SHIGENORI , NAGASHIMA TOMOHISA , OGAWA RYO , NAGASHIMA KANJI , MORIKAWA AKIHIRO 
Published: January 2011

AbstractThe unusual case of a Japanese newborn XX male is presented. Examination of chromosomes in amniotic fluid cells had shown a normal female karyotype (46,XX), but ultrasonography revealed a penis and a scrotum. The neonate had normal male external genitalia, and serum levels of luteinizing hormone follicle stimulating hormone, and testosterone were all within the normal range. High resonance chromosome analysis revealed an excess portion on the short arm of one of the X chromosoms.We examined his genomic DNA by polymerase chain reaction (PCR) and detected two Y specific regions in his genomic DNA, the sex‐determining region Y (SRY) and pseudoautosomal boundary Y. Nucleotide sequencing of the PCR products of SRY indicated no mutation.These findings suggested that the translocation or insertion of an SRY region on the X chromosome led to the development of testicles and a male phenotype.
Struggles of neonatology staff and the network system in the Hanshin‐Awaji earthquake disaster
Authors: TSUNEISHI SYUICHI , NAKAMURA HAJIME 
Published: January 2011

AbstractMore than 5500 people were killed in the Hanshin‐Awaji earthquake disaster. Most of the neonatal intensive care units (NICU) could not offer proper services as a result of the earthquake and the Hyogo Emergency System for Neonates could not function. No one imagined that such a great disaster would occur in their home town, Kobe; however, the devastation of the quake has raised the opportunity to examine the operation of neonatal medicine in an emergency.We sent out questionnaires to perinatologists in the damaged area 2–3 months after the quake. Some hospitals in the demolished area suffered such serious damage that they could not continue work as NICU, and some in the surrounding area had problems in a number of areas, including staff, room capacity and transport methods. Under these difficult circumstances the greatest problem encountered by staff was maintaining fundamental care in NICU, that is to say keeping temperature, formula (nutrition) and prevention of infection techniques operating.In this report we discuss the effects on neonatal medicine of the earthquake in Kobe. Medical staff struggled patiently and made great efforts to recover and maintain the functioning of NICU. We believe this information will be useful for neonatology staff in other areas which may experience an earthquake in the future.
Perinatal medical support in the area surrounding the Hanshin‐Awaji earthquake
Authors: KUSUDA SATOSHI , FUJIMURA MASANORI , TAKEUCHI TORU 
Published: January 2011

AbstractAfter natural disaster, perinatal medical care must usually be provided from outside the disaster area, because most of the medical efforts inside the area focus on patients without special needs. This study reviews the emergency perinatal medical response after the great Hanshin‐Awaji earthquake.In the present study, we summarize records of telephone calls and reports from the Neonatal Mutual Cooperative System (NMCS). The day of the earthquake, very little information was available to or from the disaster area. The day after the earthquake, Osaka City General Hospital (OCGH) and Osaka Medical Center and Research Institute for Maternal and Child Health were established as key facilities, and OCGH served as a center through which information passed to and from the disaster area. Most telephone calls to OCGH were placed on the second day after the earthquake by pregnant women concerned about their deliveries. Many high‐risk pregnancies and newborn infants were transferred out of the disaster area over the next month.This analysis shows that although the emergency response was very rapid in this instance, the operation may be significantly improved in disasters of this magnitude: (i) if a communication mechanism able to serve a large volume is established; (ii) if helicopter transport was easily available; and (iii) if key facilities to handle communications were previously established so as to be available immediately.
Difficulties of families with handicapped children after the Hanshin‐Awaji earthquake
Authors: TAKADA SATOSHI , SHINTANI YUKIHIRO , SOHMA OSAMU , TSUNEISHI SYUICHI , UETANI YOSHIYUKI , NAKAMURA HAJIME 
Published: January 2011

AbstractIn order to clarify the difficulties which handicapped people experienced in the Hanshin‐Awaji earthquake disaster, 678 families with handicapped children were studied 1.5 months after the earthquake.All the students who were enrolled in this study were going to some type of school or training classes for handicapped children in January 1995. The study was completed between 1 and 10 March. The questionnaires which were designed for this study consisted of three parts: the difficulties which the families were faced with, their requirements for social and medical services and the symptoms and reactions of their children after the earthquake. A total of 466 answers were obtained from their parents.The kinds of difficulties differed between the families of mentally retarded children and those of the physically handicapped. While many parents with physically handicapped children desired better medical information or materials, many parents with mentally retarded children wanted better care services for their children. Physical and psychological effects of the earthquake were only temporary in most cases. However, some of the handicapped children were still suffering from such reactions as of 10 March.From the results of our study it became evident that a systematic relief program for these handicapped people should be established. The relief program should include the distribution of information regarding medical and social services. Psychological reactions such as panic, excitement and suppression of mental activity were still observed in some handicapped children on 10 March. Further observation will therefore be necessary.
Treating early mental health and post‐traumatic symptoms of children in the Hanshin‐Awaji earthquake
Authors: NAGAO K. , OKUYAMA M. , MIYAMOTO S. , HABA T. 
Published: January 2011

AbstractIn this article we report on the support facilities for child mental health after the earthquake in Kobe. We believe that the most important function is the ability to cope with the confused situation on‐the‐spot as there were no means of transport and facilities for medical treatment had been paralyzed.Establishing contact with people outside the stricken area is of great help immediately following a disaster. After the earthquake many children were psychologically confused and people were therefore concerned with mental health care, especially for their children. However, there were only a few cases of patients seeing their doctors in medical centers. They needed information booklets or case reports to refer to.Five months after the disaster symptoms such as acute uneasiness or terror seem to be few and severely ill patients have started to recover. There are few case reports on children who have had difficulties in adapting to educational organization such as day nurseries and elementary schools. However, recently there has been an increase in the number of bone fractures possibly due to decline in resistance. Means of dealing with child mental health are now being examined because some children are still suffering posttraumatic symptoms.In this report we analyze the rapid recognition of children's mental health problems at home, in the school and in society and examine the importance of close mother‐child, family and relative relationships.
Changes with growth hormone treatment in growth hormone deficient children
Authors: ÖCAL GÖNÜL , BERBEROGLU MERIH , AKÇURİN SEMA , MEMİOGLU NIHAL , İKİNCİOGULLARI AYDAN 
Published: January 2011

AbstractA total of 54 previously untreated patients (15 girls, 39 boys) with poor growth due to idiopathic growth hormone deficiency (IGHD) were treated with human growth hormone (hGH), continuously up to 4 years. All of the patients had a peak hGH level which was below 10 ng/mL after at least two pharmacological tests and/or blunted physiologic hGH secretion, and their height was below −2.5 s.d. for age and gender.After the 1st year of therapy, height velocity (HV) increased significantly when compared with baseline (from 3.18 ±0.76 cm/year to 9.17±1.03 cm/year; P <0.001), declined during the 2nd year and then remained significantly higher than pretreatment HV. When considering improvement in height expressed by height standard deviation score (SDS), during the therapy all of the patients showed a significant gain ± 1.72±1.09 (from −4.11±0.61 to −2.21±0.48). The height values were significantly higher than pretreatment, but remained below −2 s.d. after 4 years of hGH therapy in our patients. Increased height velocity has been sustained, but height improvement after therapy was inversely correlated to height SDS for chronological age of patients at the start of therapy.In conclusion post‐treatment height has been shown to be related to height deficit at the beginning of therapy.Therapy was well tolerated with no local or systemic adverse effects or acceleration of bone age.
Effects of cytokines on hematopoietic progenitor cells in cord blood, in bone marrow, and in peripheral blood mobilized by chemotherapy and G‐CSF
Authors: URASHIMA MITSUYOSHI , HOSHI YASUTAKA , AKIYAMA MASAHARU , KAMIJO MAKOTO , SHISHIKURA AKIHIRO , KATO YOKO , AKATSUKA JUN‐ICHI , MAEKAWA KIHEI 
Published: January 2011

AbstractWe compared the effects of various combinations of cytokines (stem cell factor [SCF], interleukin [IL] −3, IL‐6, granulocyte‐colony stimulating factor [G‐CSF], erythropoietin [EPO]) among the growth of human hematopoietic progenitor cells from cord blood (CB), bone marrow (BM), and peripheral blood mononuclear cells (MNC) mobilized by chemotherapy and G‐CSF (PB) in a semi‐solid medium. Macroscopic colonies, that were visible to the naked eye, were formed from PB‐MNC within 1 week even without cytokines. They consisted of blasts containing macrophage‐like cells with immature nuclei on Wright stain, and were strongly accelerated by IL‐3. Macroscopic colonies were also formed from CB‐MNC. However, they appeared after 1–3 weeks and synergistic effects of SCF with other cytokines, especially EPO, were prominent. Macroscopic colonies were not formed from BM‐MNC. Granulocyte‐colony stimulating factor was effective in increasing colony forming units of granulocyte macrophage from BM‐MNC and they appeared between 1 and 2 weeks. These results suggested that the quality of hematopoietic progenitor cells was different among blood sources. This might lead to different bone marrow recovery patterns after transplantation of each blood source. The appropriate cytokines should be added to evaluate their exact potential.
Urine microscopy on a counting chamber for diagnosis of urinary infection
Authors: HIRAOKA MASAHIRO , HIDA YUKIO , HORI CHIKAHIDE , TSUCHIDA SHINYA , KURODA MITSUHIKO , SUDO MASAKATSU 
Published: January 2011

AbstractSeveral quantitiative methods of urine microscopic examination for bacteriuria and pyuria on a blood cell counting‐chamber have been found reliable for the diagnosis of urinary tract infection (UTI). However, no one technique has become popular or widely used because of laborious procedures associated with the method. We investigated the usefulness of microscopic examination of uncentrifuged urine on disposable counting‐chambers.A total of 89 urine samples were obtained from 53 children (24 male and 29 female). Urine samples were examined for bacteriuria and pyuria using a disposable counting chamber and its reliability was analyzed in predicting significant bacteriuria defined by routine urine culture.Significant bacteriuria was diagnosed in 23 of 89 urine samples by urine culture. Microscopic urine examination on disposable counting‐chambers was very easy without the need to set up or wash chambers and provided immediate information. Urine bacterial concentration determined by the counting‐chamber method was closely correlated to that determined by bacterial culture. The counting‐chamber method identified bacteriuria correctly in 21 of 23 urine samples diagnosed as significant bacteriuria (sensitivity = 91%) and also gave a correct diagnosis of 64 of 66 urine samples with non‐significant bacteriuria (specificity = 98%). Nineteen of the 23 urine samples with significant bacteriuria also had pyuria. The positive predictive value of concomitant bacteriuria and pyuria was 100%. When neither bacteriuria nor pyuria was found, the negative predictive value was 100%.It was concluded that urine microscopy using disposable counting chambers was very easy, inexpensive, quick and reliable and thus an extremely useful method for diagnosing UTI.
Ranitidine administration in Henoch‐Schönlein vasculitis
Authors: NARİN NAZMİ , AKÇORAL ADNAN , ASLIN M. İZZET , ELMASTAS HÜSEYİN 
Published: January 2011

AbstractIn this study, we discuss 12 patients with gastrointestinal (GI) bleeding who were diagnosed as having Henoch Schoenlein vasculitis (HSV) in Dr Behçet Uz Children's Hospital, Izmir, between January 1991 and January 1992. Seven male and five female patients were included in the study. Their ages ranged between 6–14 years. The patients were separated into two identical groups and were given ranitidine or a placebo. Both groups were followed up for abdominal pain and GI bleeding. In the group administered ranitidine the duration and severity of abdominal pain and gastrointestinal bleeding decreased significantly as compared to the group taking placebo (P <0.05). No side effects of ranitidine were observed. As a result, it was concluded that ranitidine could be used to treat HSV with GI symptoms.
A longitudinal study on electrophysiological properties of atrioventricular accessory pathways in infants and children
Authors: DING SHULAN , SUMITOMO NAOKATA , USHINOHAMA HIROYA , YAMASHITA TSUNEHISA , HARADA KENSUKE 
Published: January 2011

AbstractIn this study the electrophysiological developmental changes of accessory pathway (AP) properties in infants and children are examined. Intracardiac and/or transesophageal electrophysiological studies were performed on seven infants (group 1, mean age 2 months) and four children (group 2, mean age 9 y; study 1), and documented orthodromic atrioventricular tachycardia in all cases. At follow‐up study (study 2), supraventricular tachycardia was induced in three of seven (43%) cases in group 1 and in all four cases in group 2. Changes in antegrade conduction properties of AP were documented by loss of pre‐excitation (two of four cases in group 1) or change to intermittent pre‐excitation (one of two cases in group 2).
Twenty‐four hour monitoring of blood pressure and heart rate in patients with chronic renal failure or renal transplant recipients: Analysis by the cosinor method
Authors: NAKAMURA IKUYA , TSUZUKI KAZUO , ITO SHIGEMITSU 
Published: January 2011

AbstractHypertension is a major problem of patients with chronic renal failure or renal transplant recipients. To clarify the characteristics of blood pressure, heart rate, and circadian rhythms of these patients we used an ambulatory blood pressure monitor (ABPM) for 24 h monitoring and analyzed the data by the cosinor method. In eight chronic renal failure patients without dialysis the midline estimating statistic of rhythm (MESOR) of diastolic blood pressure was higher than in controls, but the MESOR of systolic blood pressure was not. Of 11 patients on dialysis some had hypertension and some had hypotension. In 14 renal transplant recipients, especially those with chronic graft rejection, the MESOR of systolic and diastolic pressures were higher than controls, and the increase of blood pressure MESOR had a significant correlation with the elevation of serum creatinine levels. Circadian rhythms of blood pressure were frequently absent in the patients on dialysis, but circadian rhythms of heart rate were not. The use of an ABPM is a non‐invasive method to monitor patients and allowed us to know changes of blood pressure and heart rate in the daytime as well as during the night. For the control of hypertension in chronic renal failure, monitoring with an ABPM seems to provide invaluable information.
Fetal valproate syndrome with reduction deformity of limb
Authors: OKADA TAISUKE , TOMODA TAKASHI , HISAKAWA HIROAKI , KURASHIGE TAKANOBU 
Published: January 2011

AbstractA case is reported of a female infant having multiple anomalies, including epicanthic folds, hypertelorism, bifid nasal bridge, shallow philtrum, low‐set ears, brain atrophy, cleft palate, hemangioma on the chest, and reduction deformity of the left upper limb. This is the first case where an infant who was exposed to sodium valproate intra‐uterine has a reduction deformity of the upper limb.
Hypoplastic left heart syndrome with a single coronary artery originating from the pulmonary artery
Authors: ITO TAKUO , NIINO MASAHARU , ISHIKAWA JUNICHI , MATSUMOTO SHUHEI , MATSUURA TOSHIHITO , AOI TSUTOMU , MUKAIDA TAKAMICHI , MATSUDA HIROSHI , ANDO MASAHIKO 
Published: January 2011

AbstractA newborn male infant with hypoplastic left heart syndrome due to mitral and aortic atresia died on the third day of life. Autopsy revealed a single coronary artery originating from the pulmonary artery, reversed coarctation of the aorta, a coronary sinus type atrial septal defect and stenosis of the left subclavian artery. To our knowledge, hypoplastic left heart syndrome associated with a single coronary artery originating from the pulmonary artery has never been reported in the English or Japanese literature. This may be the first such case.
Management of meconium aspiration syndrome by tracheobronchial lavage and replacement of Surfactant‐TA
Authors: IBARA SATOSHI , IKENOUE TSUYOMU , MURATA YUJI , SAKAMOTO HIROSHI , SAITO TSUYOSHI , NAKAMURA YASUTOSHI , ASANO HITOSHI , HIRANO TAKAHIRO , KURAYA KAZUE , MARUYAMA HIDEKI , NINOMIYA YUKO 
Published: January 2011

AbstractMeconium aspiration syndrome creates mechanical airway obstruction with air trapping and atelectasis. Tracheobronchial saline lavage to dislodge meconium may precipitate respiratory distress, a wet lung appearance and respiratory failure. Two case studies are reported in which meconium aspiration resulted in mechanical obstruction and displacement of surfactant and in whom tracheobronchial saline lavage and artificial surfactant replacement reversed respiratory failure.
Marked increase of peripheral blood myeloblasts following G‐CSF therapy in a patient with acute lymphoblastic leukemia
Authors: HOSOKAWA TAKATOSHI , TOMODA TAKASHI , MISAKI YASUSHI , WAKIGUCHI HIROSHI , KURASHIGE TAKANOBU 
Published: January 2011

AbstractA 9 year old boy with acute lymphoblastic leukemia (ALL) received recombinant human granulocyte colony‐stimulating factor (rhG‐CSF) and showed a marked increment of myeloblasts in the peripheral blood. He was administered repeated courses of intermediate‐dose cytosine arabinoside (Ara‐C) therapy (1500 mg/m2, days 1–5) for frequent central nervous system (CNS) relapse of ALL. The peripheral white blood cell nadir was less than 1000/μL, so he was treated with rhG‐CSF. A marked increment of peripheral blood blasts was noted 3–5 days after rhG‐CSF treatment. These cells decreased with the appearance of mature myeloid cells and disappeared about 2 weeks after the start of treatment. These findings suggested that the blasts might have the ability to differentiate into mature myeloid cells. A control patient with repeated CNS relapse of ALL showed no increment of peripheral blood blasts after similar repeated courses of Ara‐C without rhG‐CSF treatment. Cultured peripheral blood blasts obtained from the present patient showed differentiation into mature myeloid cells by morphological studies and surface marker analysis. These findings indicate that the peripheral blood blasts drawn by G‐CSF were not leukemic blasts but normal myeloblasts.