bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting the Lack of Development of Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage
Authors: Crobeddu Emanuela , Mittal Manoj K. , Dupont Stefan , Wijdicks Eelco F.M. , Lanzino Giuseppe , Rabinstein Alejandro A. 
Published: December 2011

Background and Purpose—
Patients with aneurysmal subarachnoid hemorrhage are typically kept in the intensive care unit to be monitored for signs of delayed cerebral ischemia (DCI). Identifying patients at lower risk for DCI could have a positive financial impact by allowing earlier transfer from the intensive care unit.

Methods—
We analyzed 307 consecutive patients admitted to the intensive care unit. Demographic, clinical, and neuroimaging data were recorded. The relationship with absent DCI was analyzed using univariate and multivariate logistic regression models.

Results—

DCI did not develop in 169 patients (57.9%). Among factors at admission, age 68 years or older (
P
=0.0003; OR, 3.16; 95% CI, 1.66–6.39), World Federation of Neurological Surgeons (WFNS) I to III at presentation (
P
=0.0003; OR, 2.73; 95% CI, 1.57–4.79), WFNS I to III at worst (
P
=0.0003; OR, 2.39; 95% CI, 1.48–3.87), WFNS I to III after resuscitation (
P
=0.0006; OR, 2.85; 95% CI, 1.56–5.32), modified Fisher grade 1 to 2 (
P
=0.0021; OR, 2.43; 95% CI, 1.37–4.47), absence of intracranial hematoma (
P
=0.0042; OR, 2.26; 95% CI, 1.29–4.01), and aneurysm in the posterior circulation (
P
=0.025; OR, 1.74; 95% CI, 1.07–2.87) were associated with absence of DCI. On multivariate analysis, a model including age 68 years or older, WFNS I to III at presentation and a modified Fisher grade 1 to 2 were independently predictive of the absence of DCI, with a specificity of 100% and a positive predictive value of 100%.

Conclusions—
We propose a new model that can reliably identify patients with aneurysmal subarachnoid hemorrhage who are at very low risk for DCI. These patients could be candidates for early transfer to the general ward.
Structural Measures for Network Biology Using QuACN
Authors: Mueller Laurin AJ , Kugler Karl G , Graber Armin , Emmert-Streib Frank , Dehmer Matthias 
Published: December 2011

Abstract

Background
Structural measures for networks have been extensively developed, but many of them have not yet demonstrated their sustainably. That means, it remains often unclear whether a particular measure is useful and feasible to solve a particular problem in network biology. Exemplarily, the classification of complex biological networks can be named, for which structural measures are used leading to a minimal classification error. Hence, there is a strong need to provide freely available software packages to calculate and demonstrate the appropriate usage of structural graph measures in network biology.

Results
Here, we discuss topological network descriptors that are implemented in the R-package QuACN and demonstrate their behavior and characteristics by applying them to a set of example graphs. Moreover, we show a representative application to illustrate their capabilities for classifying biological networks. In particular, we infer gene regulatory networks from microarray data and classify them by methods provided by QuACN. Note that QuACN is the first freely available software written in R containing a large number of structural graph measures.

Conclusion
The R package QuACN is under ongoing development and we add promising groups of topological network descriptors continuously. The package can be used to answer intriguing research questions in network biology, e.g., classifying biological data or identifying meaningful biological features, by analyzing the topology of biological networks.
Neuropsychological Intervention in a Case of Korsakoff's Amnesia
Authors: Monteiro Maria de Fatima Alves , Bolognani Silvia Adriana Prado , Rivero Thiago Strahler , Bueno Orlando Francisco Amodeo 
Published: December 2011

AbstractThe cognitive symptoms that characterise the Wernicke-Korsakoff's syndrome include anterograde amnesia, confabulation, temporal–spatial disorientation, severe apathy, poor awareness of one's own mental state and changes in executive functions. Such deficits may persist even after the clinical profile stabilises. There are no studies that report an intervention after the acute phase, possibly due to the complexity of these cases. This study provides a descriptive analysis of neuropsychological rehabilitation concomitant to the neurological and psychiatric treatment of a woman who presented the symptoms described by Korsakoff. The intervention focused on reducing the impact caused by the cognitive and behavioural sequelae in the patient's daily life. It described a 25-week neuropsychological program, providing education and compensatory strategies for the patient, and also orientation and support from 2 professional caregivers and family members. Quantitative and qualitative measures were used to evaluate the effect of the intervention on memory efficacy, emotional state and social participation. Both caregivers reported a decrease in the frequency of memory lapses after treatment. Positive changes were also seen in self-care, activities at home, decision-making and participation in social activities. It is concluded that this case achieved results through the collaboration between members of an interdisciplinary team and caregivers providing daily support.
Effect of organic pollutant treatment on the growth of pea and maize seedlings
Authors: Kummerová Marie , Zezulka Štěpán , Váňová Lucie , Fišerová Helena 
Published: December 2011

Abstract
This study confirmed the considerable effect of polycyclic aromatic hydrocarbon fluoranthene (FLT; 0.01, 0.1, 1, 4 and 7 mg/l) exposure on the germination of seeds, growth and root morphology of seedlings in Zea mays and Pisum sativum. Seed germination was significantly inhibited at FLT≥0.01 mg/l in maize and at ≥1 mg/l in pea. The amount of released ethylene after 3 days of germination was significantly increased in both species at FLT≥0.1 mg/l. After 7 days of seedling cultivation a significant decrease in the dry weight of roots and shoots occurred in maize at FLT≥0.1 mg/l while in pea similar effect was observed at ≥1 mg/l. The total length of primary and lateral roots was significantly reduced by FLT≥1 mg/l in maize and by 4 and 7 mg/l in pea. The length of the non-branched part of the primary root was significantly reduced by FLT≥0.1 mg/l in maize and ≥0.01 mg/l in pea. In both species the number of lateral roots was significantly increased at FLT≤1 mg/l and inhibited at concentrations of 4 and 7 mg/l. Fluoranthene content in roots and shoots of both species positively correlated with the FLT treatment.
Intranasal insulin affects adenyl cyclase system in rat tissues in neonatal diabetes
Authors: Shpakov Alexander , Chistyakova Oksana , Derkach Kira , Moyseyuk Irina , Bondareva Vera 
Published: December 2011

Abstract
The changes in hormone-regulated adenylyl cyclase (AC) signaling system implicated in control of the nervous, cardiovascular and reproductive systems may contribute to complications of diabetes mellitus (DM). We investigated the functional state of AC system in the brain, myocardium, ovary and uterus of rats with neonatal DM and examined the influence of intranasally administered insulin on the sensitivity of this system to biogenic amines and polypeptide hormones. The regulatory effects of somatostatin and 5-HT1BR-agonist 5-nonyloxytryptamine acting via Gi protein-coupled receptors were significantly decreased in DM and partially restored in insulin-treated rats. The effects of hormones, activators of AC, are changed in tissue- and receptorspecific manner, and intranasal insulin restored the effects rather close to the level in control. In insulin-treated non-diabetic rats, AC stimulating effects of isoproterenol and relaxin in the myocardium and of human chorionic gonadotropin in the ovaries were decreased, while the effects of hormones, inhibitors of AC, were increased. These data indicate that with intranasal insulin, Gi protein-mediated signaling pathways continue to gain strength. The obtained data on the influence of hormones on AC system in the brain, myocardium, ovary and uterus allow looking anew into the mechanisms of therapeutic effects of intranasal insulin.
Phage therapy for plant disease control with a focus on fire blight
Authors: Nagy Judit , Király Lóránt , Schwarczinger Ildikó 
Published: December 2011

Abstract
The concept of using bacteriophages (bacterial viruses) as biocontrol agents in pest management emerged shortly after their discovery. Although research on phage-based biopesticides temporarily stopped with the advent of antibiotics, the appearance of antibiotic resistant bacterial strains led to a renewed interest in phage therapy for control of plant diseases. In the past twenty years numerous successful experiments have been reported on bacteriophage-based biocontrol measures, and several comprehensive studies have recently been published discussing detailed results of phage application practices in pest management, mainly from North American authors. The present review focuses on bacteriophage-mediated control of fire blight (caused by Erwinia amylovora (Burill) Winslow et al.), the most devastating bacterial disease of pome fruits. Research results from North America are discussed along with recent data from European laboratories.
Improved in vitro micropropagation method with adventitious corms and roots for endangered saffron
Authors: Zeybek Evrim , Önde Sertaç , Kaya Zeki 
Published: December 2011

Abstract
The objective of this study was to investigate development of an efficient in vitro tissue culture system for saffron (Crocus sativus L.) complete with roots and corms. In indirect organogenesis, Murashige and Skoog (MS) media with 3% (w/v) sucrose, 100 mg L−1 ascorbic acid, and the combination of 0.25 mg L−1 2,4-dichlorophenoxyacetic acid (2,4-D) and 1 mg L−1 6-benzylaminopurine (BAP) were best for callus initiation and growth while 1.5 mg L−1 BAP was excellent for high rate of adventitious shoot formation. 1 mg L−1 indole-3-butyric acid (IBA) was more preferable for adventitious corm and root initiation as well as growth. Overall, 64% rooting and 33% corm production rates were achieved in indirect organogenesis. In direct organogenesis, MS medium supplemented with 3 % sucrose, 100 mg L−1 ascorbic acid and 1 mg L−1 BAP was optimum for shoot growth. While 1 mg L−1 IBA was best for adventitious corm formation, 2 mg L−1 IBA promoted adventitious root initiation and growth. Overall, 36% and 57% of explants had corm and contractile root, respectively. The high rates suggest that efficient tissue culture system could be achieved for mass propagation and ex situ conservation of threatened saffron genetic resources.
Etching and recovery of gold from aluminum substrate in thiourea solution
Authors: Jindra Tomáš , Prokop Zdeněk , Šnita Dalimil 
Published: December 2011

AbstractThis paper deals with two (main) problems of specific gold etching from parts of industrial equipment (e.g., supporting inserts into chambers for physical or chemical vapor deposition). First part of the paper is focused on selective etching of gold from aluminum substrates. Selectivity of the reaction, i.e. leaving substrates intact, is crucial. For this reason, the environmentally friendly and safe method of etching gold in a thiourea solution was tested. This method, while well described in literature, does not preserve various substrates (e.g., aluminum, stainless steel). The main goal of this part of the paper was to understand the mechanism of the reaction and to improve the reaction selectivity towards the aluminum alloy substrate. Thus, different acidifying agents were tested. Second part of the paper is focused on recovery (reduction) of gold from thiourea solutions. Chemical, electrochemical, and biological reduction were tested for gold recovery.
Oxidation of 3,5-di-tert-butylcatechol in the presence of V-polyoxometalate
Authors: Hu Xue-Feng , Wu Lei 
Published: December 2011

AbstractThe oxidase and dioxygenase reactions of 3,5-di-tert-butylcatechol (DTBC, I) in the presence of V-polyoxometalate were studied. It was found that the addition of a Lewis base quenched the V-polyoxometalate-catalysed catechol dioxygenase reaction and catalysed the oxidase reaction selectively. The existence of V-polyoxometalate accelerates the autoxidation rate of I as demonstrated by the rate measurements. ESR and UV-VIS spectra showed that the Lewis base destroyed the dioxygenation reaction catalyst as formed and restrained its regeneration by suppressing the coordination of catechol radical to vanadium. The by-products of the dioxygenation and oxidation reactions are H2O and H2O2, respectively.
What do thermonuclear bombs have to do with intercultural hermeneutics? (Or on the superiority of Dickens over Heidegger)
Authors: Małecki Wojciech 
Published: December 2011

Abstract
In this paper, I discuss Richard Rorty’s views on intercultural hermeneutics as presented in his essay “Heidegger, Kundera, and Dickens” and in his correspondence with the Indian philosopher Anindita Niyogi Balslev. In doing so, I focus primarily on Rorty’s presumption that instead of providing an “authentic” picture of another culture, the goal of intercultural studies or hermeneutics should be to look if there is anything “of use” that a given culture offers and that is not offered by ours.
Possible application of deliberative democracy in parliament
Authors: Dolný Branislav 
Published: December 2011

Abstract
Deliberative democracy, as a dominant paradigm in contemporary democratic theory, offers a new, attractive conception of democratic legitimacy, which represents an alternative to a democracy that functions through the mechanism of political competition. A major problem with deliberation is the issue of its institutionalisation, as the theories of deliberative democracy have not produced a more specific institutional framework or form in which it could be used in political practice. Parliaments appear to be particularly suitable places for its potential implementation. Moreover, deliberative democracy could contribute to a change in discourse quality and the way decision-making is conducted in parliaments, which is often considered problematic. Due to its incompatibility with competitive democracy, the opportunities for introducing deliberative democracy into parliaments are very limited. The study also outlines three ways of reconciling deliberative democracy and parliaments.
The pragmatist conception of altruism and reciprocity
Authors: Višňovský Emil 
Published: December 2011

Abstract
The paper provides an account of the pragmatist philosophical conception of reciprocity and altruism based on the ontology of “panrelationalism”. The Deweyan concepts of transaction and cooperation are also outlined in some detail as well as the pragmatist (Rortyan) idea of justice. The author attempts to show that altruism is not necessarily just reciprocal but demands as its supplement (at least) altruism without reciprocation.
Stages of development in the Polish Carpathian Foredeep basin
Authors: Oszczypko Nestor , Oszczypko-Clowes Marta 
Published: December 2011

AbstractIn southern Poland, Miocene deposits have been recognised both in the Outer Carpathians and the Carpathian Foredeep (PCF). In the Outer Carpathians, the Early Miocene deposits represent the youngest part of the flysch sequence, while in the Polish Carpathian Foredeep they are developed on the basement platform. The inner foredeep (beneath the Carpathians) is composed of Early to Middle Miocene deposits, while the outer foredeep is filled up with the Middle Miocene (Badenian and Sarmatian) strata, up to 3,000mthick. The Early Miocene strata are mainly terrestrial in origin, whereas the Badenian and Sarmatian strata are marine. The Carpathian Foredeep developed as a peripheral foreland basin related to the moving Carpathian front. The main episodes of intensive subsidence in the PCF correspond to the period of progressive emplacement of the Western Carpathians onto the foreland plate. The important driving force of tectonic subsidence was the emplacement of the nappe load related to subduction roll-back. During that time the loading effect of the thickening of the Carpathian accretionary wedge on the foreland plate increased and was followed by progressive acceleration of total subsidence. The mean rate of the Carpathian overthrusting, and north to north-east migration of the axes of depocentres reached 12 mm/yr at that time. During the Late Badenian-Sarmatian, the rate of advance of the Carpathian accretionary wedge was lower than that of pinch-out migration and, as a result, the basin widened. The Miocene convergence of the Carpathian wedge resulted in the migration of depocentres and onlap of successively younger deposits onto the foreland plate.
Comments to X. Li and Y. M. Wang (2011) Comparisons of geoid models over Alaska computed with different Stokes' kernel modifications, JGS 1(2): 136-142
Authors: Sjöberg L. 
Published: December 2011

Comments to X. Li and Y. M. Wang (2011) Comparisons of geoid models over Alaska computed with different Stokes' kernel modifications, JGS 1(2): 136-142Li and Wang recently compared geoid determination by various gravimetric methods for modifying Stokes' formula vs. using GPS/levelling geoid heights as a reference model. Possible large systematic errors in the differences of gravimetric and GPS/levelling geoid models deteriorate the results and conclusions. Moreover, spectral combination, the only stochastic method in the study, was applied in an unrealistic way.
Pathogenic Natural Antibodies Propagate Cerebral Injury Following Ischemic Stroke in Mice
Authors: Elvington Andrew , Atkinson Carl , Kulik Liudmila , Zhu Hong , Yu Jin , Kindy Mark S. , Holers V. Michael , Tomlinson Stephen 
Published: December 2011

Abstract
Self-reactive natural Abs initiate injury following ischemia and reperfusion of certain tissues, but their role in ischemic stroke is unknown. We investigated neoepitope expression in the postischemic brain and the role of natural Abs in recognizing these epitopes and mediating complement-dependent injury. A novel IgM mAb recognizing a subset of phospholipids (C2) and a previously characterized anti-annexin IV mAb (B4) were used to reconstitute and characterize injury in Ab-deficient Rag1−/− mice after 60 min of middle cerebral artery occlusion and reperfusion. Reconstitution with C2 or B4 mAb in otherwise protected Rag1−/− mice restored injury to that seen in wild-type (wt) mice, as demonstrated by infarct volume, demyelination, and neurologic scoring. IgM deposition was demonstrated in both wt mice and reconstituted Rag1−/− mice, and IgM colocalized with the complement activation fragment C3d following B4 mAb reconstitution. Further, recombinant annexin IV significantly reduced infarct volumes in wt mice and in Rag1−/− mice administered normal mouse serum, demonstrating that a single Ab reactivity is sufficient to develop cerebral ischemia reperfusion injury in the context of an entire natural Ab repertoire. Finally, C2 and B4 mAbs bound to hypoxic, but not normoxic, human endothelial cells in vitro. Thus, the binding of pathogenic natural IgM to postischemic neoepitopes initiates complement-dependent injury following murine cerebral ischemia and reperfusion, and, based also on previous data investigating IgM reactivity in human serum, there appears to be a similar recognition system in both mouse and man.
Importance of Antibody in Virus Infection and Vaccine-Mediated Protection by a Latency-Deficient Recombinant Murine γ-Herpesvirus-68
Authors: Freeman Michael L. , Burkum Claire E. , Woodland David L. , Sun Ren , Wu Ting-Ting , Blackman Marcia A. 
Published: December 2011

Abstract
The human γ-herpesviruses EBV and Kaposi’s sarcoma-associated herpesvirus establish lifelong latent infections, can reactivate in immunocompromised individuals, and are associated with the development of malignancies. Murine γ-herpesvirus-68 (γHV68), a rodent pathogen related to EBV and Kaposi’s sarcoma-associated herpesvirus, provides an important model to dissect mechanisms of immune control and investigate vaccine strategies. Infection of mice with γHV68 elicits robust antiviral immunity, and long-term protection from γHV68 reactivation requires both cellular and humoral immune responses. Vaccination of mice with AC-replication and transcription activator (RTA), a highly lytic latency-null recombinant γHV68, results in complete protection from wild-type γHV68 infection that lasts for at least 10 mo. In this report, we examine the immune correlates of AC-RTA–mediated protection and show that sterilizing immunity requires both T cells and Ab. Importantly, Ab was also critical for mitigating viral infection in the brain, and in the absence of Ab-mediated control, amplification of the AC-RTA virus in the brain resulted in fatality. Our results highlight important considerations in the development of vaccination strategies based on live-attenuated viruses.
IL-33–Responsive Lineage−CD25+CD44hi Lymphoid Cells Mediate Innate Type 2 Immunity and Allergic Inflammation in the Lungs
Authors: Bartemes Kathleen R. , Iijima Koji , Kobayashi Takao , Kephart Gail M. , McKenzie Andrew N. , Kita Hirohito 
Published: December 2011

Abstract
Innate immunity provides the first line of response to invading pathogens and a variety of environmental insults. Recent studies identified novel subsets of innate lymphoid cells that are capable of mediating immune responses in mucosal organs. In this paper, we describe a subset of lymphoid cells that is involved in innate type 2 immunity in the lungs. Airway exposure of naive BALB/c or C57BL/6J mice to IL-33 results in a rapid (&lt;12 h) production of IL-5 and IL-13 and marked airway eosinophilia independently of adaptive immunity. In the lungs of nonsensitized naive mice, IL-33–responsive cells were identified that have a lymphoid morphology, lack lineage markers, highly express CD25, CD44, Thy1.2, ICOS, Sca-1, and IL-7Rα (i.e., Lin−CD25+CD44hi lymphoid cells), and require IL-7Rα for their development. Airway exposure of naive mice to a clinically relevant ubiquitous fungal allergen, Alternaria alternata, increases bronchoalveolar lavage levels of IL-33, followed by IL-5 and IL-13 production and airway eosinophilia without T or B cells. This innate type 2 response to the allergen is nearly abolished in mice deficient in IL-33R (i.e., ST2), and the Lin−CD25+CD44hi lymphoid cells in the lungs are required and sufficient to mediate the response. Thus, a subset of innate immune cells that responds to IL-33 and vigorously produces Th2-type cytokines is present in mouse lungs. These cells may provide a novel mechanism for type 2 immunity in the airways and induction of allergic airway diseases such as asthma.