bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic epilepsy associated with temporal tumors: long-term surgical outcome
Authors: Ruban Dmitry , Byrne Richard W. , Kanner Andres , Smith Michael , Cochran Elizabeth J. , Roh David , Whisler Walter W. 
Published: July 2009

Object
The authors undertook a study to review the clinical features and outcome in patients who underwent surgery for intractable chronic epilepsy caused by temporal lobe tumors.

Methods
The Rush Surgical Epilepsy Database was queried to identify patients with chronic intractable epilepsy who underwent resection of temporal lobe tumors between 1981 and 2005 at Rush University Medical Center. Medical records were reviewed for age of the patient at seizure onset, delay to referral for surgery, seizure frequency and characteristics, preoperative MR imaging results, extent of resection, pathological diagnosis, complications, duration of follow-up period, and seizure improvement.

Results
Thirty-eight patients were identified, all with low-grade tumors. Gangliogliomas were the most common (36.8%), followed in descending order by dysembryoplastic neuroepithelial tumors (26.3%) and low-grade diffuse astrocytoma (10.5%). The mean duration between seizure onset and surgery was 15.4 years. Complex partial seizures were the most common presenting symptom. Detailed operative data were available for 28 patients; of these, 89.3% underwent complete resection of the amygdala, and 82.1% underwent partial or complete resection of hippocampus, in addition to lesionectomy. The mean follow-up duration was 7.7 years (range 1.0–23.1 years), with 78.9% of patients having seizure status that improved to Engel Class I, 15.8% to Engel Class II, and 5.3% to Engel Class III. Permanent complications were noted in 2.6% of patients.

Conclusions
The authors' examination of the long-term follow-up data in patients with temporal lobe tumors causing chronic intractable epilepsy demonstrated excellent results in seizure improvement after surgery.
Gliomas of the cingulate gyrus: surgical management and functional outcome
Authors: von Lehe Marec , Schramm Johannes 
Published: July 2009

Object
In this paper, the authors' goal was to summarize their experience with the surgical treatment of gliomas arising from the cingulate gyrus.

Methods
The authors analyzed preoperative data, surgical strategies, complications, and functional outcome in a series of 34 patients (mean age 42 years, range 12–69 years; 14 females) who underwent 38 operations between May 2001 and November 2008.

Results
In 7 cases (18%) the tumor was located in the posterior (parietal) part of the cingulate gyrus, and in 31 (82%) the tumor was in the anterior (frontal) part. In 10 cases (26%) the glioma was solely located in the cingulate gyrus, and in 28 cases (74%) the tumor extended to the supracingular frontal/parietal cortex. Most cases (23 [61%]) had seizures as the presenting symptom, 8 patients (24%) suffered from a hemiparesis/hemihypesthesia, and 4 patients (12%) had aphasic symptoms.
The authors chose an interhemispheric approach for tumor resection in 11 (29%) and a transcortical approach in 27 (71%) cases; intraoperative electrophysiological monitoring was applied in 23 (61%) and neuronavigation in 15 (39%) cases. A > 90% resection was achieved in 32 (84%) and > 70% in another 5 (13%) cases. Tumors were classified as low-grade gliomas in 11 cases (29%). A glioblastoma multiforme (WHO Grade IV, 10 cases [26%]) and oligoastrocytoma (WHO Grade III, 9 cases [24%]) were the most frequent histopathological results.
Postoperatively, patients in 13 cases suffered from a transient supplementary motor area syndrome (34%), all of whom had tumors in the anterior cingulate gyrus. In the early postoperative period (30 days) a new deficit occurred in 5 cases (13%, mild motor deficits or aphasic symptoms). One patient had a major bleeding episode 2 days after surgery and was in a persistent vegetative state.

Conclusions
Gliomas arising from the cingulate gyrus are rare. A gross-total resection is often possible and acceptably safe; intraoperative monitoring and neuronavigation are helpful adjuncts. In case of resection of gliomas arising from the anterior cingulate gyrus a supplementary motor area syndrome has to be considered, particularly when the tumor extends to the supracingular cortex
Risk profile associated with convexity meningioma resection in the modern neurosurgical era
Authors: Sanai Nader , Sughrue Michael E. , Shangari Gopal , Chung Kenny , Berger Mitchel S. , McDermott Michael W. 
Published: July 2009

Object
Although meningiomas are commonly found along the supratentorial convexity, the risk profile associated with this subset of lesions in the modern neurosurgical era is unknown.

Methods
The authors retrospectively reviewed the clinical course of patients with supratentorial convexity meningiomas treated during the past 10 years. All patients had undergone MR imaging within 72 hours after surgery and at least 1 year of clinical follow-up. Patients with multiple meningiomas, hemangiopericytomas, malignant meningiomas, or tumor-prone syndromes were excluded from analysis.

Results
Between 1997 and 2007, 141 consecutive patients (median age 48 years, range 18–95 years) underwent resection of a supratentorial convexity meningioma. The most common signs or symptoms at presentation were headache (48%), seizures (34%), and weakness (21%). The mean tumor volume was 146.3 cm3 (range 1–512 cm3). There were no intraoperative complications or deaths. Medical or neurosurgical morbidity was noted in the postoperative course of 14 patients, equating to a 10% overall complication rate. Postoperative surgical complications included hematoma requiring evacuation, CSF leakage, and operative site infection. Medical complications included pulmonary embolus and deep vein thrombosis requiring treatment. A Simpson Grade 0 or 1 resection was achieved in 122 patients (87%). One hundred six tumors (75%) were WHO Grade I, whereas 35 (25%) were WHO Grade II. The median clinical follow-up was 2.9 years (range 1–10 years), and the median radiographic follow-up was 3.7 years (range 1–10 years). Six patients (4%) had radiographic evidence of tumor recurrence, with 3 (2%) undergoing repeat resection.

Conclusions
With the conservative recommendations for surgery for asymptomatic meningiomas and the advent of radiosurgery during the past 10 years, microsurgically treated convexity meningiomas are now typically large in size. Nevertheless, the patient's clinical course following microsurgical removal of these lesions is expected to be uncomplicated. The authors' findings provide a defined risk profile associated with the resection of supratentorial convexity meningiomas in the modern neurosurgical era.
Endovascular recanalization of the completely occluded internal carotid artery using a flow reversal system at the subacute to chronic stage
Authors: Terada Tomoaki , Okada Hideo , Nanto Masataka , Shintani Aki , Yoshimura Ryo , Kakishita Koji , Masuo Osamu , Matsumoto Hiroyuki , Itakura Toru , Ohshima Kosuke , Yamaga Hiroo 
Published: July 2009

Object
The efficacy and pitfalls of endovascular recanalization were evaluated in cases of internal carotid artery (ICA) occlusion in the subacute to chronic stage.

Methods
Fourteen cases (15 lesions) of symptomatic ICA occlusion with hemodynamic compromise or recurrent symptoms were treated at the subacute to chronic stage using an endovascular technique. The Parodi embolic protection system was used during the recanalization procedure to prevent embolic stroke by reversing the flow from the distal ICA to the common carotid artery.

Results
Recanalization of the occluded ICA was possible in 14 of 15 lesions. The occlusion points were 10 cervical ICAs and 4 petrous/cavernous ICAs in successfully recanalized cases. Ischemic symptoms disappeared completely after the treatment, and new ischemic symptoms did not appear related to the treated lesion. Single photon emission computed tomography findings demonstrated the improvement of hemodynamic compromise in all cases. One case showed right middle cerebral artery branch occlusion during the procedure, but this patient's neurological symptoms were stable due to preexisting hemiparesis. Endovascular recanalization was possible and effective in improving hemodynamic compromise. However, there are still several problems with this technique, such as hyperperfusion syndrome after recanalization, cerebral embolism during treatment, durability after treatment, and identification of the occlusion point before treatment.

Conclusions
Endovascular recanalization using an embolic protection device can be considered as an alternative treatment for symptomatic ICA occlusion with hemodynamic compromise or refractoriness to antiplatelet therapy, even in the subacute to chronic stage of the illness.
Topical Anesthesia in Strabismus Surgery: A Review of 101 Cases
Authors: Seijas Olga , de Liaño Pilar Gómez , Merino Pilar , Roberts Clare J. , de Liaño Rosario Gómez 
Published: July 2009

Purpose:
To analyze the results over a 10-year period with a different type of strabismus surgery performed with topical anesthesia, to describe the differences in technique compared with surgery performed with general anesthesia, and to detail current indications and technical changes made according to the experience accrued during these years.

Methods:
A total of 101 patients undergoing strabismus surgery with topical anesthesia in a single hospital were analyzed. These patients were randomly selected from a total of 567 patients who had undergone extra-ocular muscle surgery in the past 10 years.

Results:
A good result was obtained (squint angle < 10 prism diopters and absence of diplopia) in 95% of patients immediately after surgery and in 85% at final follow-up (mean follow-up: 3.1 years). The mean operating time for each muscle was 29 minutes. Surgery was well tolerated in every patient. Conversion to general anesthesia was not necessary in any case. Atropine was used in three patients (3%) because of induction of the vagal reflex.

Conclusion:
Topical anesthesia in strabismus surgery is a useful technique in the treatment of extraocular muscle pathology, with few limitations. Appropriate monitoring by an anesthetist is vital to ensure adequate control of pain and possible side effects and to enable conversion to general anesthesia. The oculocardiac reflex is infrequent. For experienced strabismus surgeons, the total surgical time is comparable with topical and general anesthesia.

[J Pediatr Ophthalmol Strabismus 2009;46:218–222.]
Apoptotic Count as a Guide for Histological Grading of Carcinoma Esophagus: A Light Microscopic Study
Authors: Seth Ankit , Agarwal Asha 
Published: July 2009

ABSTRACT
Background: Many studies have been done in the past on the correlation between apoptotic count and histological grading of different tumors.
Aims: The study aims to find out if a correlation between apoptotic count and histological grading exists in squamous cell carcinoma of the esophagus, and also to review the literature on such a relationship in the context of some other tumors.
Settings and Design: Cases of squamous cell carcinoma of the esophagus who presented at a tertiary care center over a period of one year were reviewed.
Materials and Methods: The endoscopic biopsy specimens of 56 patients of squamous cell carcinoma of esophagus were fixed in 10% buffered formalin, processed for routine paraffin sections, sections taken, stained by hematoxylin and eosin and examined under light microscope, using 40x objective and 10x eyepiece. Apoptotic bodies were counted in each high-power field (HPF).
Statistical Analysis Used: Standard error of difference in apoptotic count in different tumor groups found and P value calculated, using Student′s t test.
Results: An inverse correlation of the apoptotic count per HPF with the histological grade of the tumor was found.
Conclusions: Grading of squamous cell carcinoma of esophagus, solely on the basis of apoptotic count can be used in the first place or to corroborate conventional histological grading done on the basis of morphology.
The effects of interleaved practice
Authors: Taylor Kelli , Rohrer Doug 
Published: July 2009

AbstractPrevious research shows that interleaving rather than blocking practice of different skills (e.g.abcbcacabinstead ofaaabbbccc) usually improves subsequent test performance. Yet interleaving, but not blocking, ensures that practice of any particular skill is distributed, orspaced, because any two opportunities to practice the same task are not consecutive. Hence, because spaced practice typically improves test performance, the previously observed test benefits of interleaving may be due to spacing rather than interleavingper se. In the experiment reported herein, children practiced four kinds of mathematics problems in an order that was interleaved or blocked, and the degree of spacing was fixed. The interleaving of practice impaired practice session performance yet doubled scores on a test given one day later. An analysis of the errors suggested that interleaving boosted test scores by improving participants' ability to pair each problem with the appropriate procedure. Copyright © 2009 John Wiley & Sons, Ltd.
A heterogeneous kinetic model of the oxidative polymerization of 2,6‐dimethylphenol with a copper‐EDTA complex in water
Authors: Liu Qun , Shentu Baoqing , Gu Cheng , Zhu Jinhua , Weng Zhixue 
Published: July 2009

AbstractThe heterogeneous oxidative polymerization kinetics of 2,6‐dimethylphenol (DMP) catalyzed by a copper(II)‐EDTA complex in water was studied. During the oxidative polymerization of DMP in water the oxygen uptake rate increases with an increase in DMP concentration and an increase in temperature. The Michaelis–Menten kinetic model as applied to the polymerization of DMP in organic solvents is not appropriate for the description of the full course of DMP polymerization in water. A new heterogeneous kinetic model is proposed to describe the catalyst deactivation during the oxidative polymerization as well as the difference in reactivity between the monomer, water‐soluble oligomer and water‐insoluble oligomer. The polymerization rate estimated by the new model is consistent with the measured data. © 2009 American Institute of Chemical Engineers AIChE J, 2009
Role of bed height and amount of dust on the efficiency of sound‐assisted fluidized bed filter/afterburner
Authors: Chirone Riccardo , Urciuolo Massimo 
Published: July 2009

AbstractA 40‐mm sound‐assisted fluidized bed filter/afterburner for hot gas clean‐up has been characterized in terms of bed saturation time, total amount of collected particles, fraction of fine particles permanently adhered on the coarse bed particles, and efficiency of using a regeneration strategy based on mechanical (attrition) and/or chemical (combustion) action. Experiments have been carried out at ambient temperature as well as at 850°C, with and without application of sound and varying bed height and amount of dust in the gas flow. The controversial effect of the application of sound: not only enhancement of particles interactions but also increase of fines permanently adhering on bed coarse particles is presented and discussed. A simplified model has been developed to obtain rough predictions of bed height which maximize fine particles capture, bed saturation time, total amount of particles collected in the bed, fraction of fine particles loading present as adhered particles on bed particles. © 2009 American Institute of Chemical Engineers AIChE J, 2009
Retreatment with bortezomib alone or in combination for patients with multiple myeloma following an initial response to bortezomib
Authors: Sood Raman , Carloss Harry , Kerr Robert , Lopez Jose , Lee Martin , Druck Mark , Walters Ian B. , Noga Stephen J. 
Published: July 2009

AbstractThis clinical trial was conducted to determine the safety and efficacy of bortezomib retreatment in patients with multiple myeloma (MM) who had previously responded to bortezomib. Patients with progressive MM who had previously tolerated bortezomib as a single agent or in combination with other drugs, with a minimum of partial response (PR; ≥50% M‐protein reduction) for ≥4 months, who had not received intervening MM therapy, were retreated with bortezomib (days 1, 4, 8, and 11 of a 21‐day cycle) with a starting dose being the dose at which the patient ended the initial treatment. Patients were allowed to receive bortezomib on retreatment in combination with dexamethasone, thalidomide, or doxorubicin. Thirty‐two patients received bortezomib retreatment (most with added dexamethasone). The median treatment‐free interval (last dose of initial bortezomib treatment to first dose of retreatment) was 9.9 (range 2.5–34.0) months. The median duration of retreatment was 2.8 (<1–7.9) months; median total duration of bortezomib treatment was 6.7 (2.5–19.8) months. Based on the investigators' assessment of best response, the overall response rate (complete plus PR) was 50%. The median time from start of retreatment to progressive disease (PD) was 6.6 (95% confidence interval: 5.1–9.6) months. Thirteen patients (41%) experienced PN; bortezomib‐related SAEs were reported in four patients. Retreatment with bortezomib alone or in combination is effective and well tolerated in patients with MM who have responded to their initial bortezomib treatment. Am. J. Hematol., 2009. © 2009 Wiley‐Liss, Inc.
Geometric Morphometric Methods for Bone Reconstruction: The Mandibular Condylar Process of Pico della Mirandola
Authors: Benazzi Stefano , Stansfield Ekaterina , Kullmer Ottmar , Fiorenza Luca , Gruppioni Giorgio 
Published: July 2009

AbstractThe issue of reconstructing lost or deformed bone presents an equal challenge in the fields of paleoanthropology, bioarchaeology, forensics, and medicine. Particularly, within the disciplines of orthodontics and surgery, the main goal of reconstruction is to restore or create ex novo the proper form and function. The reconstruction of the mandibular condyle requires restoration of articulation, occlusion, and mastication from the functional side as well as the correct shape of the mandible from the esthetic point of view. Meeting all these demands is still problematic for surgeons. It is unfortunate that the collaboration between anthropologists and medical professionals is still limited. Nowadays, geometric morphometric methods (GMM) are routinely applied in shape analysis and increasingly in the reconstruction of missing data in skeletal material in paleoanthropology. Together with methods for three‐dimensional (3D) digital model construction and reverse engineering, these methods could prove to be useful in surgical fields for virtual planning of operations and the production of customized biocompatible scaffolds. In this contribution, we have reconstructed the missing left condylar process of the mandible belonging to a famous Italian humanist of the 15th century, Pico della Mirandola (1463–1494) by means of 3D digital models and GMM, having first compared two methods (a simple reflection of the opposite side and the mathematical–statistical GMM approach) in a complete human mandible on which loss of the left condyle was virtually simulated. Finally, stereolithographic models of Pico's skull were prototyped providing the physical assembly of the bony skull structures with a high fitting accuracy. Anat Rec, 292:1088–1097, 2009. © 2009 Wiley‐Liss, Inc.
The Mesencephalic Reticular Formation as a Conduit for Primate Collicular Gaze Control: Tectal Inputs to Neurons Targeting the Spinal Cord and Medulla
Authors: Perkins Eddie , Warren Susan , May Paul J. 
Published: July 2009

AbstractThe superior colliculus (SC), which directs orienting movements of both the eyes and head, is reciprocally connected to the mesencephalic reticular formation (MRF), suggesting the latter is involved in gaze control. The MRF has been provisionally subdivided to include a rostral portion, which subserves vertical gaze, and a caudal portion, which subserves horizontal gaze. Both regions contain cells projecting downstream that may provide a conduit for tectal signals targeting the gaze control centers which direct head movements. We determined the distribution of cells targeting the cervical spinal cord and rostral medullary reticular formation (MdRF), and investigated whether these MRF neurons receive input from the SC by the use of dual tracer techniques in Macaca fascicularis monkeys. Either biotinylated dextran amine or Phaseolus vulgaris leucoagglutinin was injected into the SC. Wheat germ agglutinin conjugated horseradish peroxidase was placed into the ipsilateral cervical spinal cord or medial MdRF to retrogradely label MRF neurons. A small number of medially located cells in the rostral and caudal MRF were labeled following spinal cord injections, and greater numbers were labeled in the same region following MdRF injections. In both cases, anterogradely labeled tectoreticular terminals were observed in close association with retrogradely labeled neurons. These close associations between tectoreticular terminals and neurons with descending projections suggest the presence of a trans‐MRF pathway that provides a conduit for tectal control over head orienting movements. The medial location of these reticulospinal and reticuloreticular neurons suggests this MRF region may be specialized for head movement control. Anat Rec, 292:1162–1181, 2009. © 2009 Wiley‐Liss, Inc.
Effect of Hypoxia and Aging on PKC δ‐Mediated SC‐35 Phosphorylation in Rat Myocardial Tissue
Authors: Cataldi Amelia , Zingariello Maria , Rapino Monica , Zara Susi , Daniele Franca , Di Giulio Camillo , Antonucci Adriano 
Published: July 2009

AbstractNuclear speckles, which are sites of pre‐mRNA splicing and/or assembly components, are diffusely distributed throughout the nucleoplasm. They are composed of splicing factors (SFs), including SC‐35, which are nuclear proteins that remove introns (noncoding sequences in the genes) from precursor mRNA molecules, to form mature RNA, which will be transported to the cytoplasm, site of protein synthesis and activation. In light of such evidences, here we report that hypoxia modulates in vivo SC‐35 SF phosphorylation via protein kinase C (PKC) δ in young rat heart. Trichrome Mallory staining and TUNEL analysis along with immunohistochemistry and Western blotting have been performed on left ventricles excised from young and old rats exposed to intermittent hypoxia. Although young hypoxic myocardial cells appear smaller than normoxic cells, connective and endothelial components increase, SC‐35 phosphorylation is particularly evident in the endothelium and paralleled by an increased expression of vascular endothelial growth factor (VEGF). In addition, SC‐35 and PKC δ coimmunoprecipitation occurs, suggesting that SC‐35 phosphorylation could be PKC δ‐mediated and that hypoxic young heart needs to counteract the damage through a process of neoangiogenesis involving such SF. Even though the levels of SC‐35 and PKC δ are high, the similar response disclosed by normoxic and hypoxic old rat hearts (both showing a fibrotic organization, similar endothelial components and VEGF levels) could be due to the existence of an impaired oxygen sensing mechanism and thus to a low rate of angiogenesis. Anat Rec, 292:1135–1142, 2009. © 2009 Wiley‐Liss, Inc.