bluuebunny/crossref_metadata_2025_split huggingface dataset:
A CASE STUDY OF COMPREHENSIVE TREATMENT ON GAMBLING DISORDER IN ADOLESCENTS: NOVEL CHALLENGES IN LOW MIDDLE INCOME COUNTRY
Authors: Murtani *Belinda Julivia , Siste Kristiana , Hanafi Enjeline 
Published: February 2025

Abstract

Background
Gambling disorder is growing extensively in Indonesia, with the estimated prevalence in 2021 is around 1%. This figure is in line with the global prevalence, which is in the range of 0.1% to 5.8%. Recent years have seen a rise in the availability of gambling activities, particularly online gambling during the COVID- 19 pandemic and easily approved online loans. Furthermore, this issue became more complicated due to a lack of effective regulation and public awareness, impacting not just individuals but also families and society as a whole. There have been documented negative impacts of gambling disorder, such as damaged relationships, loss of employment, financial hardships, and a greater chance of mental health problems like anxiety and depression. However, treatment options and support services for people with gambling disorder are still limited in Indonesia. Adolescents with gambling disorders are particularly difficult to manage because they are still connected to their peers and find it difficult to cut back on technology use that encourages online gambling. Additionally, adolescents with immature prefrontral cortex also have poorer decision making skills and are more impulsive, thereby raising their risk of developing a gambling disorder.

Aims
The aim of the present study was to manage gambling disorder using a multi-modal approach including pharmacological and psychotherapy

Case-description
A 18-year-old male, was brought by his parents to an out-patient psychiatric clinic because his online gambling had gotten worse over the past five months. He also had premorbid antisocial personality disorder and tobacco use disorder, along with a family history of substance abuse that included his father and paternal grandmother. He had the background of progessively increasing engagement in online gambling for the past one year with consequent financial difficulties, school problems and relationship problems. His primary goal when playing online roulette, slots, and black jack was to win money, thus he could go out with friends. The patient took online loan and embezzled funds from the mosque savings, parents, uncle, and aunt. According to DSM-V, he was diagnosed with gambling disorder. He received cognitive behavioral therapy and motivational enhancement therapy at first.
Subsequently, he was prescribed 50 mg of sertraline and 10 mg of clobazam for his mood irritability brought on by the limitations of his gadget, which he also attempted to manipulate his parents in order to gain access to the gadget. Additionally, contingency management was added to improve the course of treatment.

Conclusion
The management of gambling disorders should involve a thorough treatment plan that uses a multimodal approaches. The patient has responded well and promptly to the therapeutic approaches used. Specific tailor-made therapeutic approaches for each individual need to be developed.
EXPLORING THE IMPACT OF CHILDHOOD NEGLECT ON COGNITIVE FUNCTION IN PATIENTS WITH BIPOLAR DISORDER
Authors: Hsueh *Yuanzhi , Huang Cho-Yin , Kuo Po-Hsiu , Cheng Ying-Chih , Huang Ming-Chyi , Chiu Chih Chiang , Kuo Chian-Jue , Chen Po-Yu , Chen Wen-Yin 
Published: February 2025

Abstract

Background
Bipolar disorder (BD) is a severe mental disorder associated with neurocognitive deficits. The exposure to childhood trauma experiences is also linked to poorer cognitive performance. However, there is limited reporting on the distinct compositions of childhood trauma in BD and their specific impacts on cognitive performance.

Methods
In this cross-sectional study, we utilized the Brief Assessment of Cognition in Affective Disorders (BAC-A) to evaluate cognitive performance and the Chinese version of the Childhood Trauma questionnaire-short form (C-CTQ-SF) to assess childhood trauma experiences in a sample of 55 euthymic BD patients. We applied Two-Step cluster analysis to dissect their childhood trauma experiences, revealing distinct clusters: a low-trauma group, a neglect-focus group, and a multiple trauma experience group. We compared cognitive function among these three clusters and employed a generalized linear model to assess the impact of childhood neglect trauma on cognitive domains.

Results
The neglect-focus cluster exhibited notably high levels of exposure to physical and emotional neglect (41.8%). Moreover, BD patients in this cluster performed even worse on the BAC-A compared to patients in the multiple trauma cluster, particularly in working memory and processing speed. Using the low trauma cluster as a reference, the neglect-focus group revealed a significant negative effect on the composite score (ß = -0.904, p = 0.025) and working memory (ß = -1.150, p = 0.002), after adjusting for confounding factors.

Conclusions
Distinct patterns of childhood trauma experience are observed in BD patients and are associated with different cognitive profiles. Early exposure to neglect-focus trauma is linked to the poorest cognitive performance in the current study. Further studies investigating the intensity of neglect, as well as individual resilience and coping mechanisms in BD, are warrant.
OXYTOCIN-AUGMENTED MODULAR-BASED GROUP INTERVENTION FOR LONELINESS: A RANDOMIZED-CONTROLLED TRIAL
Authors: Hurlemann *Rene , Berger Ruben , Shamay-Tsoory Simone , Kanterman Alisa , Brausa Maura , Gorni Jessica , Luhmann Maike , Schramm Elisabeth , Schultz Johannes , Philipsen Alexandra , Lieberz Jana , Scheele Dirk 
Published: February 2025

Abstract

Background
Chronic loneliness is associated with increased morbidity and mortality. The COVID-19 pandemic has highlighted the importance of loneliness as a modifiable risk factor for major depressive disorder (MDD) and generalized anxiety disorder (GAD). As a result, there is an urgent need for neurobiologically informed interventions to reduce loneliness (1).

Aims & Objectives
Given preliminary evidence for impaired oxytocin signaling in chronic loneliness (2), the current proof- of-concept study used a randomized, double-blind, placebo-controlled design to probe intranasal oxytocin (IN-OT) as an adjunct to a short-term modular-based group intervention for individuals suffering from high chronic loneliness (HL) (Fig. 1).

Method
Seventy-eight healthy HL participants (56 women) received five weekly group psychotherapy sessions targeting negative cognitive biases in loneliness. After a first orientation session, HL participants received IN-OT or placebo before therapy. Trait loneliness was measured at baseline and a week and three months after the intervention. Perceived stress, quality of live, and the therapeutic relationship were assessed at each session, while state loneliness was tested before and after each session. As an additional no-intervention control group, 49 healthy participants reporting low loneliness (26 women) were also tested twice.

Results
The intervention significantly reduced perceived stress and improved trait loneliness, which was still evident at the 3-month follow-up. IN-OT had no significant effect on these primary outcomes or quality of life. However, compared to placebo, IN-OT significantly facilitated the decrease in state loneliness within sessions and significantly enhanced positive aspects of the therapeutic relationship, in the form of improved positive bonding of the therapist with the whole group.

Discussion & Conclusion
Conclusively, the short-term group intervention improved trait loneliness, but IN-OT did not significantly augment this effect. Further studies are needed to determine optimal intervention designs to translate the observed acute effects of IN-OT into long-term benefits.

References
1.Morr M, Liu X, Hurlemann R, Becker B, Scheele D. Chronic Loneliness: Neurocognitive Mechanisms and Interventions. Psychother Psychosom. 2022;91(4):227-237.
2.Patin A, Scheele D, Hurlemann R. Oxytocin and Interpersonal Relationships. Curr Top Behav Neurosci. 2018;35:389-420.
REGIONAL HOMOGENEITY CHANGES IN CEREBRAL AND CEREBELLAR REGIONS ASSOCIATED WITH DEFAULT-MODE NETWORK FOLLOWING PROLONGED INTERMITTENT THETA-BURST STIMULATION
Authors: Cheng *Chih-Ming , Li Cheng-Ta , Bai Ya-Mei 
Published: February 2025

Abstract

Background
The medial prefrontal cortex (MPFC), which is a component of the default-mode network, has been shown to play a role in the pathophysiology of major depressive disorder and treatment-resistant depression (TRD). It has also been discovered that the cerebellum, especially the posterior lobule, exhibited strong connectivity with multiple functional networks, such as default mode and executive control networks. Patients with MDD have also been observed to have aberrant cerebellar-cerebral connectivity. In contrast to conventional seed-based functional connectivity research, studies examining regional connectivity in patients with TRD, such as regional homogeneity (ReHo), receive comparatively less attention. The potential impact of MPFC stimulation by rTMS on regional functional connectivity in the cerebral and cerebellar regions still remains unknown.

Methods
This sham-controlled, double-blind, randomized trial involved thirty patients who had developed treatment-resistant depression (TRD) and were not responding to antidepressants and standard repetitive transcranial magnetic stimulation (rTMS)/prolonged intermittent theta-burst stimulation (iTBS). The participants were randomly assigned to one of three monotherapy groups (standard iTBS-600 pulses, prolonged iTBS-1800 pulses, or sham coil). The brain stimulation targeting the bilateral dorsomedial prefrontal cortex (DMPFC) was performed twice daily for three weeks. All participants received pre- and post-treatment resting-state functional magnetic resonance imaging (rs-fMRI).

Results
Following treatment, ANOVA showed there were different reho signals in the bilateral cerebellum, precuneus and inferior parietal lobe among three groups. Further analysis revealed that the prolonged iTBS group exhibited a substantially higher reho in the bilateral posterior cerebellar lobules when compared to the sham or standard iTBS group. In contrast, the sham group displayed a higher reho in the precuneus and inferior parietal lobes than the prolonged iTBS group. There was no difference of reho between the sham and standard iTBS groups.

Conclusion
Prolonged iTBS regulated regional function homogeneity in the cerebral and cerebellar regions associated with DMN, highlighting the aberrant DMN alterations in the pathology of MDD.
DETERMINATION OF TRYPTAMINE ALKALOIDS AND THEIR STABILITY IN PSYCHOTROPIC MUSHROOMS
Authors: Kuchar *Martin , Gotwaldova Klara , Borovicka Jan , Jurok Radek , Cihlarova Petra , Hajkova Katerina 
Published: February 2025

Abstract

Synthetic psilocybin (PSB), but also the PSB-containing mushrooms are used for psychedelic therapy and microdosing. It is necessary to know alkaloids variability and stability in wild-grown mushrooms. Concentrations of other psychotropic (or potentially psychotropic) tryptamines such as psilocin (PS), baeocystin (BA), norbaeocystin (NB), and aeruginascin (AE) are also relevant. This study aims to determine the concentrations of PSB, PS, BA, NB and AE in a large sample set of mushroom genera previously reported to contain psychotropic tryptamines. Freshly cultivated fruit bodies of Psilocybe cubensis were used for monitoring stability (including storage and processing conditions of fruiting bodies). Mycelium and the individual parts of the fruiting bodies (caps, stipes, and basidiospores) were also examined. The concentration of tryptamines was analyzed using ultra-high-performance liquid chromatography coupled with mass spectrometry. Analytical standards were synthetized in house and UHPLC-MS/MS method was fully validate for quantification of tryptamine alkaloids in mushroom samples. Most mushroom collections were documented by fungarium specimens and/or ITS rDNA/LSU/EF1-α sequencing.The tryptamine concentrations in mushrooms are extremely variable, which could possibly influence the medicinal effect compared to therapy with chemically pure PSB. The storage conditions strongly affected the alkaloids decay and showed that the highest degradation of tryptamines was seen in fresh mushrooms stored at −80° C, and the lowest decay was seen in dried biomass stored in the dark at room temperature.
This study was funded by the Ministry of Health of the Czech Republic (NU21-04-00307).

References
GOTVALDOVA, K., BOROVICKA, J., HAJKOVA, K., CIHLAROVA, P., ROCKEFELLER, A. &KUCHAR, M. 2022. Extensive Collection of Psychotropic Mushrooms with Determination of Their Tryptamine Alkaloids. International Journal of Molecular Sciences, 23.
GOTVALDOVA, K., HAJKOVA, K., BOROVICKA, J., JUROK, R., CIHLAROVA, P. &KUCHAR, M. 2021. Stability of psilocybin and its four analogs in the biomass of the psychotropic mushroom Psilocybe cubensis. Drug Testing and Analysis, 13, 439-446.
CLINICAL BENEFIT AND UTILITY OF ARIPIPRAZOLE ONCE MONTHLY IN ROUTINE PRACTICE FOR KOREAN SCHIZOPHRENIA PATIENTS (CAMP)
Authors: Moon *Jiwan , Yang Hyeryun , Kim Eun Soo , Jeon Sang-Won , Shin Young-Chul , Cho Sung Joon 
Published: February 2025

Abstract

Background
Antipsychotic polypharmacy is prevalent in clinical settings, with an increasing adoption of long-acting injectables to alleviate side effects. Aripiprazole once monthly (AOM) offers enhanced compliance, functional recovery, and symptom relief, yet evidence is lacking within polypharmacy.

Aims & Objectives
The objectives of this observational study are to investigate the clinical benefits and effectiveness of AOM within a general clinical environment. This investigation entails assessing shifts in clinical functionality, alterations in psychotic symptoms, and modifications in medication dosages and quantities.

Method
Participants were recruited from six sites, and clinical as well as demographic data were extracted from electronic medical records (EMR) during the screening, baseline, 1-month, 3-month, 6-month, 9-month, and 12-month intervals, with the initiation of AOM treatment serving as the baseline point. Changes of various measures including in GAF (Global Assessment of Functioning), CGI-S (Clinical Global Impression-Severity), CGI-I (Clinical Global Impression-Improvement), PANSS-6 (The Positive and Negative Syndrome Scale-6) scores, as well as alterations in medication dosage and quantity over the 12- month period, were analyzed.

Results
Data of 85 patients were available and notable improvements were observed in key measures. The GAF score increased by 17.2%, the CGI-S score decreased by 17.5%, the CGI-I score decreased by 25%, and the PANSS-6 total score decreased by 22% at 12 months. Particularly noteworthy was the decrease of PANSS-6 score observed as early as month 1, compared to the baseline, with other scales exhibited significant improvement from month 3. At the 12-month juncture, a statistically significant reduction was evident in several medication-related aspects, including the total pill count, antipsychotic pill count, cumulative chlorpromazine-equivalent dosage of antipsychotics, benzodiazepine pill count, and cumulative lorazepam-equivalent dosage of benzodiazepines. Notably, the initial month saw a significant drop in both overall pill count and antipsychotic pill count and dosage.
Furthermore, a pronounced reduction in anticholinergic drug and beta-blocker pill counts was observed at the 12-month point compared to baseline, further suggesting AOM's contribution to reducing side effects. Although 31 subjects reported adverse events, no instances of serious adverse events were documented.

Discussion & Conclusion
The findings of this study strongly suggest that efficacy becomes apparent early on when transitioning to AOM in patients undergoing antipsychotic polypharmacy within the routine clinical practice for schizophrenia patients in Korea. The observed improvements encompass not only enhanced functionality and amelioration of clinical symptoms but also a significant reduction in medication quantity and dosage.
THE NITRIC OXIDE (NO) DONOR MOLSIDOMINE COUNTERACT BEHAVIOURAL DEFICITS RESEMBLING NEGATIVE SYMPTOMS AND COGNITIVE DEFCITS IN THE RAT
Authors: Pitsikas *Nikolaos , Katsanou Lamprini , Vartzoka Foteini 
Published: February 2025

Abstract

Background
The deficiency of the gaseous molecule nitric oxide (NO) seems to be critically involved in the pathogenesis of schizophrenia. Thus, molecules that can normalize NO levels as are the NO donors, might be of utility for the medication of this psychiatric disease.

Aims & Objectives
The aim of the present study was to detect the ability of the NO donor molsidomine to reduce schizophrenia-like impairments produced either by blockade of the N-methyl-D-aspartate (NMDA) receptor or by dysregulation of the brain dopaninergic system in the rat.

Method
Molsidomine's ability to attenuate social withdrawal and spatial recognition memory deficits induced by the NMDA receptor antagonist ketamine were assessed using the social interaction and the object location test, respectively. Further, the ability of molsidomine to attenuate spatial recognition and emotional memory deficits induced by the dopaminergic agonist apomorphine was evaluated among the object location and the step-through passive avoidance test, respectively. Finally the efficacy of the combination of sub-threshold doses of molsidomine with sub-effective doses of the atypical neuroleptics clozapine and risperidone to attenuate non-spatial recognition memory impairments caused by treatment either of ketamine or apomorphine was also assessed using the object recognition test.

Results
Molsidomine (2 and 4 mg/kg) attenuated ketamine-induced social withdrawal and counteracted spatial recognition and emotional memory deficits induced either by ketamine or apomorphine. Further, the joint administration of inactive doses of molsidomine (1 mg/kg) with those of clozapine (0.1 mg/kg) and risperidone (0.03 mg/kg) counteracted non-spatial recognition memory deficits caused either by ketamine or apomorphine.

Discussion & Conclusions
The present results indicate that molsidomine is sensitive to glutamate hypofunction since it attenuated behavioural deficits in animal models mimicking the negative symptoms and cognitive impairments of schizophrenia. Additionally, the current findings propose that molsidomine is sensitive to dopaminergic dysfunction since it reduced cognitive defcits induced by apomorphine.
Finally, the findings here reported support the potential of molsidomine as an adjunctive drug for the therapy of schizophrenia.
THE STATUS OF HOPELESSNESS AND RELATED FACTORS IN KOREAN FEMALE FULL-TIME HOMEMAKERS: A COMMUNITY-BASED CROSS- SECTIONAL SURVEY STUDY
Authors: Hwang *Tae-Young 
Published: February 2025

Abstract

Background
Although the labor of full-time homemakers contributes to the stable maintenance of society as much as that of working women, social attention and support to full-time homemakers is relatively insufficient. Accordingly, a psychiatric evaluation of the mental health status of full-time homemakers is required.

Aims & Objectives
This study aimed to investigate the status of hopelessness and related factors in community-dwelling female full-time homemakers, and to evaluate the necessity of policy approaches to the full-time homemakers as a high-risk group for mental health.

Method
This survey study were sequentially and randomly conducted targeting community-dwelling full-time female homemakers aged 19 to 50, using structured questionnaires composed of general items as well as the Korean version of Beck Hopelessness Scale (K-BHS), the Korean version of the Glasgow Sleep Effort Scale (K-GSES), and Resenberg Self-Esteem Scale (RSES). The monetary values of the labor of individual full- time homemakers were measured through the willingness-to-pay (WTP) approach.

Results
A total of 180 questionnaires were distributed, of which 154 were analyzed. In the frequency analysis, the total proportion of hopelessness group was 62.3%, of which 42.2% was for the mild level, 16.2% for moderate level, and 3.9% for the severe level. In between-group comparative analyses [Normal group (n = 58) vs. Hopelessness group (n = 96)], significant differences were manifested in the length of career (t = - 2.667, p = 0.008), level of social activity (t = 2.762, p = 0.008), degree of emotional bond with husband (t = 2.339, p = 0.021), K-GSES (t = -2.459, p = 0.015), and RSES(t = 5.380, p &lt;0.001). Furthermore, in binary logistic regression analysis, significant negative factor for the transition to the hopelessness group was level of social activity (p = 0.021; odds ratio (OR), 0.694; 95% confidence interval (CI), 0.508 - 0.946), and significant positive factor was the score on K-GSES (p = 0.041; OR, 1.155; 95% CI, 1.006 – 1.328).

Discussion & Conclusion
The findings of this study showed that a substantial number of female full-time homemakers might be in a state of hopelessness, implicating that full-time homemakers are at high-risk for mental health and suicide. Therefore, policy and psychiatric intervention to promote and recover mental health of full-time homemakers is essential.
IN VIVO CLASSIFICATION OF TAU PATHOLOGIES BY POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH FRONTOTEMPORAL DEMENTIA
Authors: Kubota *Manabu , Endo Hironobu , Takahata Keisuke , Tagai Kenji , Suzuki Hisaomi , Onaya Mitsumoto , Sano Yasunori , Yamamoto Yasuharu , Kurose Shin , Matsuoka Kiwamu , Seki Chie , Shinotoh Hitoshi , Kawamura Kazunori , Zhang Ming-Rong , Takado Yuhei , Shimada Hitoshi , Higuchi Makoto 
Published: February 2025

Abstract

Background
Frontotemporal dementia (FTD) is a group of neurodegenerative disorders with diverse clinical and neuropathological features. In vivo neuropathological assessments of FTD at an individual level have not hitherto been successful.

Aims & Objectives
In this study, we aimed to classify patients with FTD based on topologies of tau protein aggregates captured by positron emission tomography (PET) with 18F-florzolotau (aka 18F-APN-1607, 18F-PM-PBB3), which allows high-contrast imaging of diverse tau fibrils in Alzheimer’ s disease (AD) and non-AD tauopathies.

Method
Twenty-six patients with FTD, consisting of 15 patients with behavioral variant FTD (bvFTD) and 11 patients with other FTD phenotypes, and 20 age- and gender-matched healthy controls were studied. They underwent PET imaging of amyloid and tau depositions with 11C-PiB and 18F-florzolotau, respectively.

Results
By combining visual and semiquantitative analyses of PET images, the bvFTD patients were classified into the following subgroups: 1) predominant tau accumulations in frontotemporal and frontolimbic cortices resembling three-repeat tauopathies (n = 3); 2) predominant tau accumulations in subcortical structures accompanied by various degrees of neocortical accumulations resembling four-repeat tauopathies (n = 4); 3) amyloid and tau accumulations consistent with AD (n = 4); and 4) no overt amyloid and tau pathologies (n = 4). Despite these distinctions, clinical symptoms and localization of brain atrophy were not significantly different among the identified bvFTD subgroups. Patients with other FTD phenotypes were also classified into similar subgroups.

Discussion And Conclusion
PET with 18F-florzolotau potentially enables the characterization of each individual with FTD on a biological basis, thereby possibly contributing to diagnostic and therapeutic approaches to this illness.