bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unsymmetrically substituted furoxans. Part 19. Methyl and phenylfuroxansulfonic acids and related sulfonamides
Authors: Chegaev Konstantin , Rolando Barbara , Guglielmo Stefano , Fruttero Roberta , Gasco Alberto 
Published: September 2009

Abstract
magnified imageSynthesis, structural characterization, and acid dissociation constants (pKa) of a series of methyl‐ and phenyl‐substituted furoxansulfonic acids and related sulfonamide derivatives, as well as their furazan analogues are described. The ability of furoxans to dilate rat aorta strips precontracted with phenylephrine is reported as an example of their NO‐dependent pharmacological properties. J. Heterocyclic Chem., (2009).
Efficient synthesis of benzothieno[3,2‐d]‐1,2,4‐triazolo [1,5‐a]pyrimidin‐5(1H)‐ones via a tandem aza‐Wittig/heterocumulene‐mediated annulation
Authors: Xu Sheng‐Zhen , Cao Min‐Hui , Chen Chang‐Shui , Ding Ming‐Wu 
Published: September 2009

Abstract
magnified imageThe carbodiimides 2, obtained from reactions of iminophosphorane 1 with isocyanates, reacted with hydrazine to give selectively 3‐amino‐2‐arylaminobenzothieno[3,2‐d]pyrimidin‐4(3H)‐ones 4. Reactions of 4 with triphenylphosphine, hexachloroethane, and Et3N produced iminophosphoranes 5. A tandem aza‐Wittig reaction of iminophosphorane 5 with isocyanate, acyl chloride generated benzothieno[3,2‐d]‐1,2,4‐triazolo[1,5‐a]pyrimidin‐5(1H)‐ones 7 and 9 in satisfactory yields. The effects of the nucleophiles on cyclization have been investigated. J. Heterocyclic Chem., (2009).
Highly soluble perylene tetracarboxylic diimides (PDI)‐tetrathiafulvalene (TTF) dyad and TTF‐PDI‐TTF triad
Authors: Wang Chengyun , Tang Wei , Zhong Hanbin , Zhang Xuechao , Shen Yongjia 
Published: September 2009

Abstract
magnified imageTwo highly soluble donor‐σ‐acceptor and donor‐σ‐accepter‐σ‐donor type fluorescence switches consisting tetrathiafulvalene (TTF) and 3,4,9,10‐perylene tetracarboxylic diimides (PDI) were synthesized. The structure of the dyad and triad as well as their intermediates was characterized by 1H NMR, 13C NMR MS, elemental analysis. Their fluorescence behavior could be modulated by oxidization and reduction of the TTF unit using either chemical or electrochemical method. J. Heterocyclic Chem., (2009).
An efficient and direct synthesis of 2‐thiopyridines via microwave‐assisted three‐component reaction
Authors: Wang Xing‐Han , Cao Xu‐Dong , Tu Shu‐Jiang , Zhang Xiao‐Hong , Hao Wen‐Juan , Yan Shu , Wu Shan‐Shan , Han Zheng‐Guo , Shi Feng 
Published: September 2009

Abstract
magnified imageA series of 2‐p‐tolylthiopyridine derivatives was directly synthesized via three‐component reactions of chalcones, malononitrile, and 4‐methylbenzenethiol catalyzed by Et3N in DMF under microwave irradiation. It is an efficient and promising synthetic strategy to construct 2‐thiopyridine skeleton with the advantage of short time, excellent yield, and convenient operation. J. Heterocyclic Chem., (2009).
The Boulton–Katritzky rearrangement of isocarboxazid
Authors: Van Arnum Susan D. , Niemczyk Henry J. 
Published: September 2009

Abstract
magnified imageIsocarboxazid rearranges on heating to 5‐acetonyl‐2‐benzyl‐4‐hydroxy‐1,2,3‐triazole in DMF at 150°C, in the ionic liquid, [bmin]HSO at 100°C or as a melt at 105°C. This is the first reported example of the Boulton–Katritzky rearrangement of an acyl hydrazide. J. Heterocyclic Chem., (2009)
Silica gel‐supported sulfuric acid catalyzed synthesis of 1,5‐benzodiazepine derivatives
Authors: Shobha D. , Chari M. Adharvana , Mukkanti K. , Ahn K. H. 
Published: September 2009

Abstract
magnified imageSilica gel‐supported sulfuric acid has been found to be an efficient catalyst for the synthesis of 1,5‐benzodiazepines from o‐phenylenediamine and ketones in acetonitrile solvent. This method is simple, effective, and environmentally friendly and gives better yields. Compared to the classical reaction conditions, this new method consistently has the advantage of excellent yields (80–97%) and short reaction time (30–150 min) at room temperature. J. Heterocyclic Chem., (2009).
Ethyl {4‐[2‐(saccharin‐2‐yl)acetylsulfamoyl]phenylazo}cyanoacetate in the synthesis of polyfunctionally heteroaromatic derivatives
Authors: Aly A. A. 
Published: September 2009

Abstract
magnified imageAn efficient and direct one‐pot reaction of ethyl saccharinylcyanoacetate derivative 3 with a variety of active methylene reagents and nitrogen nucleophiles afforded novel series of polyfunctionally substituted heteroaromatic derivatives 5–13, respectively. The pyrazole derivative 13 was seemed to be the excellent precursors for the synthesis of pyrazolo[1,5‐a]pyrimidine derivatives 14–24. The antimicrobial screening of some synthesized products was evaluated against some selected bacteria and fungi. The structures of the synthesized derivatives were established by elemental and spectral data. J. Heterocyclic Chem., (2009).
Malpractice claims closed against hospital defendants in Florida: 1986–1993
Authors: Studnicki James , Campbell Robert R. , Werner Dennis C. , Remmel Randall 
Published: September 2009

AbstractObjective — To provide a statewide trend analysis of all hospital malpractice claims, payment amounts, and their distribution by location of the event within hospitals.Design — A retrospective, descriptive study of 7,819 hospital claims closed in the state of Florida during the period 1986 to 1993.Results — Both total claims closed (1,756) and paid (655) peaked in 1987 and declined to lows of 507 and 338, respectively, in 1993. The percentage of claims receiving a payment, however, increased steadily from a low of just under 35 percent in 1988 to nearly 67 percent in 1993. More than $537 million has been paid for 3,409 claims. The average payment amount increased an inflation‐adjusted 71 percent, from $94,000 to $212,000. Claims resulting in awards of $1 million or more represented only 3.6 percent of paid claims, but accounted for 52 percent of the total dollars awarded.
Allegations of sexual misconduct: A risk management perspective
Authors: Jones Linda E. , Adkins Elizabeth 
Published: September 2009

AbstractIncreasingly, patients are making complaints to state licensing boards and filing lawsuits against healthcare providers alleging sexual misconduct. This article addresses the risk management implications of patient allegations of sexual misconduct involving inappropriate touching by healthcare providers during an examination or treatment. From a risk management standpoint, techniques can be implemented before and after these incidents that can help reduce the facility's exposure.
Patient relations for modern times
Authors: Para Pamela J. 
Published: September 2009

AbstractA well‐organized patient relations program can improve the quality of care while reducing risk to the organization. Patient relations is also a matter of the organization's survival in a competitive marketplace. The consumer's choice for healthcare will be made based on how the organization is differentiated from other organizations with otherwise common attributes. These distinct attributes set a product or organization apart from its competitors by creating a “personality” in the marketplace. A selected program, such as patient relations, can build a marketing plan that creates an identifiable market personality with opportunity for good financial returns and stability.
Survey of hospital systems and common serious medication errors
Authors: Cohen Michael R. , Proulx Susan M. , Crawford Stephanie Y. 
Published: September 2009

AbstractThe Institute for Safe Medication Practices and the University of Illinois at Chicago, College of Pharmacy, undertook a hospital survey of medical‐surgical hospitals to determine systems‐oriented factors that allow the highest level of medication safety. The study incorporated a peer‐reviewed and pretested questionnaire, which focused on critical information necessary to yield quality data for comparison. Through analysis, it was shown that over one third of all medication errors reported in the survey involve just six categories–allergies, insulin, heparin, opiates, PCA devices, and potassium concentrates.
Unlicensed assistive personnel—risk management considerations
Authors: Shostek Kathleen 
Published: September 2009

AbstractAlong with the restructuring and downsizing of healthcare organizations is the move toward further cost‐reduction efforts, including the increased use of unlicensed assistive personnel for patient care activities. This can create new/increased risk exposures. Implications for healthcare risk managers are discussed and strategies for preventing and managing associated liability exposures are provided.
An incident reporting system: Documented at the point of service
Authors: Golden Mary Sue 
Published: September 2009

AbstractMany healthcare organizations maintain two systems for documenting incidents reports:

• A paper incident report system completed by staff and managers and
• A computerized system where clerical staff duplicate the same information in a database
This article discusses the way risk managers in hospitals and healthcare organizations can reduce paperwork and more rapidly address the implementation of a point of service computerized system to document incidents. The benefits of such a system include:

• Real‐time information and trending of occurrences
• Reduced liability by securing reports earlier
• Maintaining a higher level of confidentiality
• Earlier problem resolution
• Providing a valuable link between the risk, quality, and safety functions of the organization
Flood disaster preparedness: A retrospect from grand forks, north dakota
Authors: Siders Cindy , Jacobson Rosemary 
Published: September 2009

AbstractNatural disasters often come without warning. The clinical, financial, and business risks can be enormous. Grand Forks' (ND) healthcare systems experienced a flooding disaster of unprecedented proportions in April of 1997. Planned and practiced disaster and evacuation procedures can significantly reduce a healthcare facilities' risk to life, health, and safety. This article retrospectively analyzes disaster preparation and the complete evacuation of the facilities' patients.
Four indefensible phlebotomy errors and how to prevent them
Authors: Ernst Dennis J. 
Published: September 2009

AbstractThe author identifies four errors in phlebotomy that are effectively indefensible in a court of law: patient misidentification, improper angle of insertion, improper vein selection, and ineffective training and evaluation of those performing venipunctures. Strategies to avoid these errors include the implementation and enforcement of specific administrative and procedural policies. A side bar on the “Ten Commandments of Phlebotomy Liability” accompanies this article.
Managing workers' compensation exposures in healthcare
Authors: McDonald Linda 
Published: September 2009

AbstractEmployees in healthcare are exposed to numerous and varied risks that pose the threat of injury. Management of those exposures by the organization will ultimately help create a safe environment for staff, patients and the public. Incorporating workers' compensation into the risk management program is the first step toward managing and reducing these exposures. This article presents a suggested outline for a written risk management plan for workers' compensation exposures.
Y2K, embedded chips, casualty hazards and due diligence in healthcare risk management
Authors: Childers J. Richard 
Published: September 2009

AbstractY2K raises challenges for healthcare risk managers that go beyond information technology issues. This article explains that (1) too little public attention is being paid to equipment which may well have Y2K faults and (2) few standards have been articulated for dealing with problems. Healthcare risk managers therefore must return to basic due diligence principles and develop their own standards and protocols. The article explains how to do due diligence and outlines suggested steps for dealing with the non‐information technology side of compliance due diligence.
Physicians' cognitive errors and their liability consequences
Authors: Bartlett Edward E. 
Published: September 2009

AbstractDiagnostic errors account for one‐fifth of lawsuits against hospitals and physicians. Of greatest concern is the rising severity of lawsuits alleging diagnostic errors—over a 12‐year period the average indemnity for these claims has risen by 258%. The hospital departments most affected are the emergency room, obstetrics, radiology and pathology. This article probes the structure of diagnostic errors and makes recommendations how to reduce the frequency and severity of these claims.
High reliability perinatal units: An approach to the prevention of patient injury and medical malpractice claims
Authors: Knox G. Eric , Simpson Kathleen Rice , Garite Thomas J. 
Published: September 2009

AbstractPerinatal units differ in their ability to prevent patient injury and medical malpractice litigation. Obstetrical units with favorable performance are distinguished by common organizational and clinical features. Organizationally, they resemble what behavioral scientists define as “high‐reliability organizations” (i.e., the ability to operate technologically complex systems essentially without error over long periods). Clinically, practices are based on nationally recognized guidelines and/or an operational philosophy of “safety first.” These organizational and clinical features are described so that physicians, nurses, and administrators might view their own clinical environments in the context of this perspective.
Sexual harassment: An ominous liability for healthcare professionals
Authors: West John C. 
Published: September 2009

AbstractSexual harassment can arise in virtually any employment setting. Healthcare facilities must be careful to avoid sexual harassment of their employees both fry other employees and by the myriad other persons who may come into contact with their employees in the workplace. Much of what makes sexual harassment an actionable offense are the perceptions of the victim. Employers should take a proactive approach to preventing, detecting and correcting instances of harassment.
Risk management and pollution prevention: Thinking outside the box
Authors: Brannan Wayne L. , Carstarphen Kristin , Lightburn Jaconda , Black Aileen 
Published: September 2009

AbstractThe Medical University of South Carolina's risk management department received a 12‐month grant from South Carolina's General Assembly “Hazardous Waste Management Research Fund” for the purpose of identifying pollution prevention opportunities within South Carolina healthcare facilities. One hundred and one healthcare facilities were invited to participate in this study. Facilities ranged in size from zero‐licensed beds (clinics) to more than 300 beds. Seventy‐six South Carolina facilities (75%) participated in this project.
Uterine rupture during trial of labor: Risk management recommendations
Authors: Schnitker Korliss Ann 
Published: September 2009

AbstractIn the early 1990s, the cesarean section rate in the United States reached a plateau of approximately 24% of all births. Today, for a variety of reasons, significant efforts are under way to decrease this cesarean rate of almost one in four births. One area of focus is on efforts to decrease the number of “repeat” cesarean sections. Accordingly, the practice of vaginal birth after cesarean section (VBAC) has become commonplace in obstetrical units across the country. Experience now suggests that a history of cesarean delivery increases the risks for mother and child in future deliveries. One of these risks is uterine rupture. This article examines related trends, reviews guidelines promulgated by professional organizations and related literature, and offers risk management recommendations for mitigating the risks of VBAC.
Risk management issues in the reuse of single‐use medical devices
Authors: West John C. 
Published: September 2009

AbstractThe future of the practice of reusing single‐use medical devices is currently uncertain because the U.S. Food and Drug Administration is poised to promulgate regulations on the subject. This article deals with the risk issues associated with contracting with an external vendor to perform this function under current FDA regulations and provides guidance for minimizing these risks.
Pediatric anesthesia: A large problem in small people
Authors: Huntington Elizabeth A. 
Published: September 2009

AbstractAbout 70 percent of all pediatric care is delivered in non‐pediatric hospitals. A variety of factors have prompted community hospitals to initiate or expand existing pediatric surgical services. These include changes in medical economics and the evolving payer system, urban sprawl, patient access demands, and better community availability of pediatric sub‐specialists. Moreover, some community hospitals are providing complex pediatric surgery or are operating on young infants — services that were once exclusively the domain of the tertiary pediatric provider. These recent demographic changes have raised concerns regarding the quality and safety of anesthesia services at these institutions.This article discusses the unique characteristics of the pediatric surgical patient and the clinical risks associated with pediatric anesthesia. The authors offer strategies and recommendations for ensuring patient safety and managing credentialing and privileging issues.
Binding of phosphorylated peptides and inhibition of their interaction with disease‐relevant human proteins by synthetic metal‐chelate receptors
Authors: Riechers Alexander , Grauer Andreas , Ritter Stefan , Sperl Bianca , Berg Thorsten , König Burkhard 
Published: September 2009

AbstractThe modulation of biological signal transduction pathways by masking phosphorylated amino acid residues represents a viable route toward pharmacologic protein regulation. Binding of phosphorylated amino acid residues has been achieved with synthetic metal‐chelate receptors. The affinity and selectivity of such receptors can be enhanced if combined with a second binding site. We demonstrate this principle with a series of synthetic ditopic metal‐chelate receptors, which were synthesized and investigated for their binding affinity to phosphorylated short peptides under conditions of physiological pH. The compounds showing highest affinity were subsequently used to inhibit the interaction of the human STAT1 protein to a peptide derived from the interferon‐γ receptor, and between the checkpoint kinase Chk2 and its preferred binding motif. Two of the investigated ditopic synthetic receptors show a significant increase in inhibition activity. The results show that regulation of protein function by binding to phosphorylated amino acids is possible. The introduction of additional binding sites into the synthetic receptors increases their affinity, but the flexibility of the structures investigated so far prohibited stringent amino acid sequence selectivity in peptide binding. Copyright © 2009 John Wiley & Sons, Ltd.
A social identity perspective on leadership and employee creativity
Authors: Hirst Giles , van Dick Rolf , van Knippenberg Daan 
Published: September 2009

AbstractThis research uses a social identity analysis to predict employee creativity. We hypothesized that team identification leads to greater employee creative performance, mediated by the individual's creative effort. We hypothesized that leader inspirational motivation as well as leader team prototypicality would moderate the relationship between identification and creative effort. Consistent with these predictions, data based on 115 matched pairs of employee‐leader ratings in a research and development context showed an indirect relationship between team identification and creative performance mediated by creative effort. The analyses also confirmed the expected moderated relationships. Leader inspirational motivation enhanced the positive association between identification and creative effort, especially when leader prototypicality was high. We discuss the value of social identity analyses of employee creativity and of the integration of social identity and transformational leadership analyses. Copyright © 2009 John Wiley & Sons, Ltd.
Teleworker knowledge sharing and the role of altered relational and technological interactions
Authors: Golden Timothy D. , Raghuram Sumita 
Published: September 2009

AbstractGiven the growing importance and complexities of telework and the challenges associated with knowledge sharing, in this study we investigate teleworkers and their propensity to share knowledge. We do so by investigating if the relational qualities of teleworkers in the form of trust, interpersonal bond, and commitment, act to impact teleworker knowledge sharing. We also investigate how telework's altered spatial and technical interactions shape knowledge sharing, by testing the contingent role of technology support, face‐to‐face interactions, and electronic tool use. Results using matched data from 226 teleworkers support the role of teleworker trust, interpersonal bond, and commitment in predicting knowledge sharing. Moreover, the impact of trust on knowledge sharing is found to be moderated by technology support, face‐to‐face interactions, and use of electronic tools, whereas the impact of commitment is contingent upon the use of electronic tools. Copyright © 2009 John Wiley & Sons, Ltd.
The role of affective experience in work motivation: Test of a conceptual model
Authors: Seo Myeong‐Gu , Bartunek Jean M. , Barrett Lisa Feldman 
Published: September 2009

AbstractThe purpose of this paper was to contribute to understanding of the crucial role of emotion in work motivation by testing a conceptual model developed by Seo, Barrett, and Bartunek (2004) that predicted the impacts of core affect on three behavioral outcomes of work motivation, generative‐defensive orientation, effort, and persistence. We tested the model using an Internet‐based investment simulation combined with an experience sampling procedure. Consistent with the predictions of the model, pleasantness was positively related to all three of the predicted indices. For the most part, these effects occurred indirectly via its relationships with expectancy, valence, and progress judgment components. Also as predicted by the model, activation was directly and positively related to effort. Copyright © 2009 John Wiley & Sons, Ltd.
Differentiation of eight tea (Camellia sinensis) cultivars in China by elemental fingerprint of their leaves
Authors: Chen Yingxu , Yu Mingge , Xu Jie , Chen Xincai , Shi Jiyan 
Published: September 2009

AbstractBACKGROUND: Tea is an infusion made from dried leaves of tea (Camellia sinensis) and can be a good dietary source of essential trace metals for humans. Therefore, it is necessary to consider variations in element content of tea leaves among tea cultivars. Thus, elemental fingerprint techniques, based on elemental contents (Al, B, Ca, Cd, Co, Cr, Cu, Fe, K, Mg, Mn, Na, P, Pb, and Zn) determined by inductively coupled plasma atomic emission spectrometry (ICP‐AES) and multivariate statistical analysis, have been used to differentiate eight tea cultivars.RESULTS: The ranges of element concentrations in leaves of the eight cultivars were in good agreement with those obtained in previous studies and the level of most elements in tea leaves was significantly different among cultivars. The classifications of eight tea cultivars were 100% accurate in total by principal component analysis (PCA), hierarchical cluster analysis (HCA), linear discriminant analysis (LDA), and back‐propagation neural network (BPNN) analysis.CONCLUSION: Each cultivar presented a distinctive element fingerprint and the elements in tea leaves can be significant predictors in differentiating tea cultivars. Copyright © 2009 Society of Chemical Industry