bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recipient donor sex combinations in solid organ transplantation and impact on clinical outcome: A scoping review
Authors: Magyar Christian Tibor Josef , Gretener Charlene Pierrine , Baldi Patricia , Storni Federico , Kim‐Fuchs Corina , Candinas Daniel , Berzigotti Annalisa , Knecht Matthias , Beldi Guido , Hirzel Cédric , Sidler Daniel , Reineke David , Banz Vanessa 
Published: April 2024

AbstractIntroductionSolid organ transplantation (SOT) is a lifesaving treatment for end‐stage organ failure. Although many factors affect the success of organ transplantation, recipient and donor sex are important biological factors influencing transplant outcome. However, the impact of the four possible recipient and donor sex combinations (RDSC) on transplant outcome remains largely unclear.MethodsA scoping review was carried out focusing on studies examining the association between RDSC and outcomes (mortality, graft rejection, and infection) after heart, lung, liver, and kidney transplantation. All studies up to February 2023 were included.ResultsMultiple studies published between 1998 and 2022 show that RDSC is an important factor affecting the outcome after organ transplantation. Male recipients of SOT have a higher risk of mortality and graft failure than female recipients. Differences regarding the causes of death are observed. Female recipients on the other hand are more susceptible to infections after SOT.ConclusionDifferences in underlying illnesses as well as age, immunosuppressive therapy and underlying biological mechanisms among male and female SOT recipients affect the post‐transplant outcome. However, the precise mechanisms influencing the interaction between RDSC and post‐transplant outcome remain largely unclear. A better understanding of how to identify and modulate these factors may improve outcome, which is particularly important in light of the worldwide organ shortage. An analysis for differences of etiology and causes of graft loss or mortality, respectively, is warranted across the RDSC groups.Practitioner points
Recipient and donor sex combinations affect outcome after solid organ transplantation.
While female recipients are more susceptible to infections after solid organ transplantation, they have higher overall survival following SOT, with causes of death differing from male recipients.
Sex‐differences should be taken into account in the post‐transplant management.
Impact of hyperparathyroidism on allograft histology and function after kidney transplantation: Rethinking its causal role in graft dysfunction
Authors: Cojuc‐Konigsberg Gabriel , Tinajero‐Sánchez Denisse , Canaviri‐Flores Vianca Anabel , Fueyo‐Rodríguez Omar , Uribe‐Uribe Norma O. , Marino‐Vazquez Lluvia A. , Morales‐Buenrostro Luis Eduardo , Ramirez‐Sandoval Juan C. 
Published: April 2024

AbstractIntroductionThe causal relationship between hyperparathyroidism and kidney graft dysfunction remains inconclusive. Applying Bradford‐Hill's temporality and consistency causation principles, we assessed the effect of parathyroid hormone (iPTH) on graft histology and eGFR trajectory on kidney transplant recipients (KTRs) with normal time‐zero graft biopsies.MethodsRetrospective cohort study evaluating the effect of hyperparathyroidism on interstitial fibrosis and tubular atrophy (IF/TA) development in 1232 graft biopsies. Pre‐transplant hyperparathyroidism was categorized by KDIGO or KDOQI criteria, and post‐transplant hyperparathyroidism by iPTH >1× and >2× the URL 1 year after transplantation.ResultsWe included 325 KTRs (56% female, age 38 ± 13 years, follow‐up 4.2 years [IQR: 2.7‐5.8]). Based on pre‐transplant iPTH levels, 26% and 66% exceeded the KDIGO and KDOQI targets, respectively. There were no significant differences in the development of >25% IF/TA between KTRs with pre‐transplant iPTH levels above and within target range according to KDIGO (53% vs. 62%, P = .16, HR.94 [95% CI:.67–1.32]) and KDOQI (60% vs. 60%, P = 1.0, HR 1.19 [95% CI:.88–1.60]) criteria. Similarly, there were no differences when using 1 year post‐transplant iPTH cut‐offs > 88 pg/mL (58% vs. 64%, P = .33) and > 176 pg/mL (55% vs. 62%, P = .19). After adjusting for confounders, no significant differences were observed in eGFR trajectories among the iPTH strata.ConclusionIn young KTRs who received a healthy graft, no association was found between increased pre‐ and post‐transplant iPTH levels and graft dysfunction, as assessed histologically and through eGFR trajectory. The concept of hyperparathyroidism as a risk factor for graft dysfunction in recipients at low risk requires reevaluation.
Diel vibrational activity of Halyomorpha halys and its implications for enhancing bimodal traps
Authors: Fouani Jalal M. , Bonet Mattia , Zaffaroni‐Caorsi Valentina , Nieri Rachele , Verrastro Vincenzo , Anfora Gianfranco , Mazzoni Valerio 
Published: April 2024

AbstractThe brown marmorated stink bug, Halyomorpha halys (Stål) (Hemiptera: Pentatomidae) is an invasive insect pest that has caused significant economic losses in a myriad of agricultural crops in Europe and the USA. The communication as well as the control of this pest largely rely on semiochemicals (e.g., pheromones) and semiophysicals (e.g., substrate‐borne vibrations). Nevertheless, the nocturnal activity of H. halys is still largely unknown. In the present study, the diel vibrational communication of H. halys was investigated in controlled laboratory and semi‐field conditions. Moreover, the relevance of this ecological trait for integrated pest management (IPM) strategies was assessed by extending playback periods of bimodal (i.e., pheromones + vibrational playbacks) traps to 24 h, and comparing it to the current trap model (solar panel, about 12 h of playback) and a control (no playback, only pheromone). We found that H. halys did not exhibit discernible differences of vibrational activity between photophase and scotophase, with the exception of signal type 2 that in laboratory conditions was predominately emitted within nocturnal and morning hours (i.e., 20:00–12:00). Additionally, the calling activity was negatively affected by warmer (>32 °C) and windier (>7 m s−1) conditions in semi‐field settings. Bimodal traps that were power‐supplied for 24 h captured significantly more males than the other groups, and more females than the control group. Results suggest that the nocturnal vibrational activity of H. halys should be accounted for within IPM strategies by activating the bimodal traps also during the scotophase.
Social capital and supply chain relationships
Authors: Kang Namho , Nemani Alok , Raman Kartik 
Published: April 2024

AbstractWe examine the role of social capital in influencing decisions pertaining to buyer–supplier relationships. We report that firms make larger relationship‐specific investments when their supply chain partners are headquartered in states with high social capital. This result is more pronounced when supply chain partners have incentives to engage in opportunistic behavior. Furthermore, the duration of supply chain relationships is longer when the firm and its supply chain partner are both headquartered in high social capital states, and when the partner invests in relationship‐specific assets. Collectively, the evidence suggests that social norms reflecting trustworthiness facilitate investment and stability along supply chains.
Population dynamics and stock assessment of Queenfish (Scomberoides commersonnianus) from the marine waters of Bangladesh
Authors: Barua Suman , Liu Qun , Azam Mohammed Shariful 
Published: April 2024

AbstractThe Queenfish, Scomberoides commersonnianus, is a large commercial fish in Bangladesh. This is the first study on the Queenfish that aims to elucidate life history parameters and stock status to suggest authority for sustainable management and to support future research on this economically significant species in the region. We used three length‐based approaches to establish a standard for sustainable management of the fishery: (1) TropFishR to give the growth parameters and current exploitation status, (2) the length‐based Bayesian biomass estimation (LBB) to quantify stock biomass, (3) and Froese's sustainability indicators (LBI). The length–weight relationship of Queenfish was a negative allometric pattern (b = 2.84; R2 = 0.98). Growth parameters for Queenfish were L∞ = 124.22 cm, K = 0.31 year−1. Instantaneous total mortality Z = 0.71 year−1, instantaneous natural mortality M = 0.36 year−1, and instantaneous fishing mortality F = 0.35 year−1. Based on the LBB approach, the current estimated stock biomass was overexploited (B/BMSY = 0.65). We recommend strictly maintaining mesh size of nets to reduce harvest of immature fish shorter than 62 cm, while focusing harvest on fish 62–74 cm, to minimise recruitment and growth overfishing.
Lived experience and family engagement in psychiatry research: A scoping review of reviews
Authors: Hawke Lisa D. , Sheikhan Natasha Y. , Rodak Terri 
Published: April 2024

AbstractBackgroundA growing body of research is addressing the process and science of engaging people with lived experience (PWLE) of mental health challenges and other psychiatric conditions, and family members, in research activities.ObjectiveThis scoping review of reviews synthesizes literature reviews on the engagement of PWLE and family members in research across the field of psychiatry.MethodSystematic searches were conducted in seven bibliographic databases. Records were independently screened first at the title and abstract level, then at the full‐text level. Included were any literature synthesis studies published in English, French, or Spanish in any given year, focusing on the engagement of PWLE and/or family members in research within psychiatry. Twenty records were included. Data were extracted in a spreadsheet and codebook thematic analysis was used across the body of articles to synthesize the findings.ResultsAspects of PWLE engagement have been synthesized in 20 review articles reviewing 376 articles across psychiatry as a whole and several subpopulations, including youth mental health, dementia, neurodevelopmental disorders, people who use drugs, and forensic mental health. Information specific to family engagement is lacking. Barriers, facilitators, and positive impacts of PWLE engagement have been widely reported across domains of research, with a considerable degree of consensus across subpopulations. Some negative impacts and reporting challenges have also been identified.DiscussionThis scoping review of reviews provides an overarching understanding of the current state of the science of PWLE and family engagement across psychiatry research. The findings can inform future research practices enriched with a genuine and effective engagement with PWLE and families.Patient or Public ContributionThe authorship team includes members with intersecting lived experience and academic identities. Additional lived experience engagement was not conducted as part of this review.
Exploring the association between internalized weight bias and mental health among Canadian adolescents
Authors: Lucibello Kristen M. , Goldfield Gary S. , Alberga Angela S. , Leatherdale Scott T. , Patte Karen A. 
Published: April 2024

SummaryBackgroundInternalized weight bias (IWB) has been identified as a correlate of higher depressive and anxiety symptoms in adolescents with higher weights. However, there has been limited investigation into how IWB relates to positive mental health and whether these associations differ across genders.ObjectivesTo examine the associations between IWB and mental health (depression, anxiety, flourishing) in adolescents with higher weights, and to test the potential moderating role of gender.MethodsCanadian adolescents with higher weights (N = 7538, 60% boys, 36% girls, 4% gender diverse, ages 12–19) from the COMPASS study completed a survey during the 2021–2022 school year. Data were analysed using generalized linear models.ResultsHighest IWB and poorest mental health were noted within gender diverse adolescents, followed by girls then boys. Gender moderated the relationship between higher IWB and higher depression, higher anxiety and lower flourishing, with the strongest relationships noted among girls.ConclusionIWB interventions should be tailored to gender subgroups that may be particularly vulnerable to maladaptive mental health outcomes associated with IWB. System‐level changes that mitigate perpetuation of weight bias and discrimination which lead to IWB are also essential, particularly for girls.
Irisin attenuates ventilator‐induced diaphragmatic dysfunction by inhibiting endoplasmic reticulum stress through activation of AMPK
Authors: Zhang Jumei , Tu Rui , Guan Fasheng , Feng Jianguo , Jia Jing , Zhou Jun , Wang Xiaobin , Liu Li 
Published: April 2024

AbstractMechanical ventilation (MV) is an essential life‐saving technique, but prolonged MV can cause significant diaphragmatic dysfunction due to atrophy and decreased contractility of the diaphragm fibres, called ventilator‐induced diaphragmatic dysfunction (VIDD). It is not clear about the mechanism of occurrence and prevention measures of VIDD. Irisin is a newly discovered muscle factor that regulates energy metabolism. Studies have shown that irisin can exhibit protective effects by downregulating endoplasmic reticulum (ER) stress in a variety of diseases; whether irisin plays a protective role in VIDD has not been reported. Sprague–Dawley rats were mechanically ventilated to construct a VIDD model, and intervention was performed by intravenous administration of irisin. Diaphragm contractility, degree of atrophy, cross‐sectional areas (CSAs), ER stress markers, AMPK protein expression, oxidative stress indicators and apoptotic cell levels were measured at the end of the experiment.Our findings showed that as the duration of ventilation increased, the more severe the VIDD was, the degree of ER stress increased, and the expression of irisin decreased.ER stress may be one of the causes of VIDD. Intervention with irisin ameliorated VIDD by reducing the degree of ER stress, attenuating oxidative stress, and decreasing the apoptotic index. MV decreases the expression of phosphorylated AMPK in the diaphragm, whereas the use of irisin increases the expression of phosphorylated AMPK. Irisin may exert its protective effect by activating the phosphorylated AMPK pathway.
The physiological role of TRP channels in sleep and circadian rhythm
Authors: Woodard Geoffrey E. , Rosado Juan A. , Li He 
Published: April 2024

AbstractTRP channels, are non‐specific cationic channels that are involved in multiple physiological processes that include salivation, cellular secretions, memory extinction and consolidation, temperature, pain, store‐operated calcium entry, thermosensation and functionality of the nervous system. Here we choose to look at the evidence that decisively shows how TRP channels modulate human neuron plasticity as it relates to the molecular neurobiology of sleep/circadian rhythm. There are numerous model organisms of sleep and circadian rhythm that are the results of the absence or genetic manipulation of the non‐specific cationic TRP channels. Drosophila and mice that have had their TRP channels genetically ablated or manipulated show strong evidence of changes in sleep duration, sleep activity, circadian rhythm and response to temperature, noxious odours and pattern of activity during both sleep and wakefulness along with cardiovascular and respiratory function during sleep. Indeed the role of TRP channels in regulating sleep and circadian rhythm is very interesting considering the parallel roles of TRP channels in thermoregulation and thermal response with concomitant responses in growth and degradation of neurites, peripheral nerves and neuronal brain networks. TRP channels provide evidence of an ability to create, regulate and modify our sleep and circadian rhythm in a wide array of physiological and pathophysiological conditions. In the current review, we summarize previous results and novel recent advances in the understanding of calcium ion entry via TRP channels in different sleep and circadian rhythm conditions. We discuss the role of TRP channels in sleep and circadian disorders.
Dexamethasone promotes renal fibrosis by upregulating ILT4 expression in myeloid‐derived suppressor cells
Authors: Gu Xiaowen , Zhang Lianmei , Sun Min , Zhou Ying , Ji Jinling , Xu YunFang , You Jianguo , Deng Zhikui 
Published: April 2024

AbstractStudies have shown that adoptive transfer of myeloid‐derived suppressor cells (MDSCs) can alleviate various inflammatory diseases, including glomerulonephritis, but the long‐term effects of the transferred MDSCs are still unclear. In addition, although glucocorticoids exert immunosuppressive effects on inflammatory diseases by inducing the expansion of MDSCs, the impact of glucocorticoids on the immunosuppressive function of MDSCs and their molecular mechanisms are unclear. In this study, we found that adoptive transfer of MDSCs to doxorubicin‐induced focal segmental glomerulosclerosis (FSGS) mice for eight consecutive weeks led to an increase in serum creatinine and proteinuria and aggravation of renal interstitial fibrosis. Similarly, 8 weeks of high‐dose dexamethasone administration exacerbated renal interstitial injury and interstitial fibrosis in doxorubicin‐induced mice, manifested as an increase in serum creatinine and proteinuria, collagen deposition and α‐SMA expression. On this basis, we found that dexamethasone could enhance MDSC expression and secretion of the fibrosis‐related cytokines TGF‐β and IL‐10. Mechanistically, we revealed that dexamethasone promotes the expression of immunoglobulin‐like transcription factor 4 (ILT4), which enhances the T‐cell inhibitory function of MDSCs and promotes the activation of STAT6, thereby strengthening the expression and secretion of TGF‐β and IL‐10. Knocking down ILT4 alleviated renal fibrosis caused by adoptive transfer of MDSCs. Therefore, our findings demonstrate that the role and mechanism of dexamethasone mediate the expression and secretion of TGF‐β and IL‐10 in MDSCs by promoting the expression of ILT4, thereby leading to renal fibrosis.
Optimizing lipid control in Taiwanese diabetic patients: A collaborative consensus by the Diabetes Association of the Republic of China (Taiwan) and the Taiwanese Association of Diabetes Educators
Authors: Shen Feng‐Chih , Chu Chih‐Hsun , Chen Jung‐Fu , Kuo Chin‐Sung , Hsu Chih‐Yao , Lin Ching‐Han , Sheen Yi‐Jing , Su Sheng‐Chiang , Tien Kai‐Jen , Lu Chieh‐Hua , Lee Chun‐Chuan , Yang Yi‐Sun , Tu Shih‐Te , Chen Po‐Tsang , Chen Ching‐Chu , Chien Ming‐Nan , Li Hung‐Yuan , Sheu Wayne Huey‐Herng , Huang Chien‐Ning , Wang Chih‐Yuan , Ou Horng‐Yih 
Published: April 2024

AbstractWe present an in‐depth analysis of dyslipidemia management strategies for patients with diabetes mellitus in Taiwan. It critically examines the disparity between established guideline recommendations and actual clinical practices, particularly in the context of evolving policies affecting statin prescriptions. The focus is on synthesizing the most recent findings concerning lipid management in patients with diabetes mellitus, with a special emphasis on establishing consensus regarding low‐density lipoprotein cholesterol treatment targets. The article culminates in providing comprehensive, evidence‐based recommendations tailored to the unique needs of those living with diabetes mellitus in Taiwan. It underscores the criticality of personalized care approaches, which incorporate multifaceted factors, and the integration of novel therapeutic options to enhance cardiovascular health outcomes.
Democracy and stock market returns
Authors: Lei Xun , Wisniewski Tomasz Piotr 
Published: April 2024

AbstractIn this article, we empirically examine the relation between democracy level and stock index returns in a sample of 74 countries. Compared with democracies, autocratic states are characterized by lower returns despite exhibiting higher return volatility. Even though this higher volatility can be mostly attributed to diversifiable country‐specific risk, the capital asset pricing model cannot explain the return differential. Instead, it is the level of investor protection that can fully account for the phenomenon described here. Autocratic leaders may be reluctant to promulgate regulations shielding investors, and the resultant expropriation depresses the returns realized by outsiders.
Nitrous Oxide Use for Pain in Labor, Conversion to Neuraxial Analgesia, and Birth Outcome
Authors: DeJoy Susan , Killeen Candice , Jackson‐Köhlin Donna , Psaltis Audrey , Knee Alexander 
Published: April 2024

IntroductionA variety of labor pain management options is essential to patients and their care providers. Inhaled, patient controlled nitrous oxide (N2O) is a valuable addition to these options. The purpose of this study was to examine laboring patient, newborn, and provider characteristics associated with N2O use for pain relief in labor and to examine the association between N2O, conversion to neuraxial analgesia, and cesarean birth.MethodsThis was a retrospective observational cohort study of the first year of N2O use in one large academic medical center. Patients at least 37 weeks’ gestation who were admitted for labor with intended vaginal birth from August 1, 2018, to June 30, 2019, were included (N = 2605). Laboring patient and newborn factors and their relationship to N2O use were calculated as unadjusted and adjusted relative risks (RRs). Poisson regression was used to model the association between N2O use and subsequent use of neuraxial analgesia and type of birth for both nulliparous and multiparous patients.ResultsOverall, 20.2% of patients used N2O during labor. Multiparous patients were 24% less likely to use N2O than nulliparous patients (RR, 0.76; 95% CI, 0.69‐0.84). Use of N2O did not differ significantly between patients cared for by midwives compared with patients cared for by physicians (RR, 0.95; 95% CI, 0.90‐1.00). In multivariable modeling, N2O use in multiparous patients was associated with a 17% decrease in use of neuraxial analgesia (RR, 0.83; 95% CI, 0.73‐0.94). There was no association between N2O use and use of neuraxial analgesia in nulliparous patients (RR, 0.99; 95% CI, 0.93‐1.06). N2O use was not associated with cesarean birth in either group.DiscussionN2O is an important pain management option for laboring patients and those who care for them. Study results may assist midwives, physicians, and nurses in counseling patients about analgesia options.
Neural correlates of chocolate brand preference: A functional MRI study
Authors: Peiris Senal , Tobia Michael J. , Smith Andrew , Grun Emily , Elyan Rommy , Eslinger Paul J. , Yang Qing X. , Karunanayaka Prasanna 
Published: April 2024

AbstractBackground and PurposePreferences can be developed for, or against, specific brands and services. Using two functional magnetic resonance imaging (fMRI) experiments, this study investigated two dissociable aspects of reward processing, craving and liking, in chocolate lovers. The goal was to further delineate the neural basis supporting branding effects using familiar chocolate (FC) and unfamiliar chocolate (UC) brand images.MethodsIn the first experiment, subjects rated their subjective craving and liking on a scale of 1‐5 (weak‐strong) for each FC and UC image. In the second experiment, they performed a choice task between FC and UC images.ResultsBoth the craving and liking ratings were significantly greater for FC and were differentially correlated with choice behavior. Craving ratings predicted greater preference for UC, and liking ratings predicted greater preference for FC. A contrast of neural activity for UC versus FC choice trials revealed significantly greater activation for UC choices in the bilateral inferior frontal gyrus and right caudate head. Response times for the FC images were faster than UC images; fMRI activity in the ventromedial prefrontal cortex was significantly correlated with response times during FC trials, but not UC trials. These correlations were significantly different from each other at the group level.ConclusionsThe choices for branded chocolate products are driven by higher subjective reward ratings and lower neural processing demands.