bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frequency of Chronic Headaches in Japanese Patients With Multiple Sclerosis: With Special Reference to Opticospinal and Common Forms of Multiple Sclerosis
Authors: Doi Hikaru , Matsushita Takuya , Isobe Noriko , Ishizu Takaaki , Ohyagi Yasumasa , Kira Jun‐ichi 
Published: April 2009

Background.— Headache is common in Western patients with multiple sclerosis (MS), but its frequency has not been reported in Asian patients. In Asians, the opticospinal form of MS, showing similar characteristics to relapsing neuromyelitis optica in Westerners, is regarded as a different subtype from conventional MS.Objectives.— The aim of this study was to clarify the frequency of primary and chronic secondary headaches in Japanese patients with MS and the factors associated with the emergence of such headaches.Methods.— We investigated 127 consecutive patients with clinically definite MS. Frequencies of primary and chronic secondary headaches were compared according to clinical subtype, administration of interferon beta, and anti‐aquaporin‐4 antibody status.Results.— The frequency of patients with primary and chronic secondary headaches at the time of interview was 64/127 (50.4%); the frequency of migraine was 26/127 (20.4%) and that of tension‐type headache was 38/127 (29.9%). The frequencies of patients with primary and chronic secondary headaches and migraine without aura after the onset of MS were higher in patients undergoing interferon beta therapy than in those not on the therapy (42.4% vs 23.4%, P < .05 and 15.1% vs 4.3%, P = .05, respectively). There were no significant differences in the frequency of primary and chronic secondary headaches based on clinical subtype of MS. However, among patients not receiving interferon beta, the occurrence of migraine with aura after the onset of MS was significantly higher in patients with anti‐aquaporin‐4 antibody than in patients without the antibody (13.3% vs 0.0%, P < .05).Conclusions.— In Japanese patients with MS, the frequency of primary and chronic secondary headaches, especially migraine, was higher than in the general Japanese population. Administration of interferon beta was related to a higher frequency of primary and chronic secondary headaches, especially migraine without aura, irrespective of clinical subtype of MS.
No Influence of 5‐HTTLPR Gene Polymorphism on Migraine Symptomatology, Comorbid Depression, and Chronification
Authors: Wieser Thomas , Dresler Kathrin , Evers Stefan , Gaul Charly , König Dorothea , Hölzl Daniela , Berger Klaus , Nyholt Dale , Deufel Thomas 
Published: April 2009

(Headache 2010;50:420‐430)Background.— The serotonergic system is thought to play an important role for mediating susceptibility to migraine and depression, which is frequently found comorbid in migraine. The functional polymorphism in the serotonin transporter gene linked polymorphic region (5‐HTTLPR/SLC6A4) was previously associated with attack frequency and, thus, possibly with chronification.Objective.— We hypothesized that patients with the “s” allele have higher attack frequency and, paralleling results in depression research, higher scores of depression.Methods.— Genetic analysis of the SLC6A4 44 bp insertion/deletion polymorphism (5‐HTTLPR) was performed in 293 patients with migraine with and without aura. Self‐rating questionnaires were used for assessment of depression.Results.— Multinomial logistic regression analysis found no evidence for association of the 5‐HTTLPR polymorphism with either depression or migraine attack frequency.Conclusion.— We were not able to demonstrate any influence of the serotonin transporter 5‐HTTLPR polymorphism on migraine phenomenology (attack frequency or comorbid depression), thereby excluding this variant to be a common genetic denominator for chronic migraine and depression.
Rejection and Acceptance of Possible Side Effects of Migraine Prophylactic Drugs
Authors: Kowacs Pedro A. , Piovesan Elcio J. , Tepper Stewart J. 
Published: April 2009

Introduction.— Successful prophylactic therapy might require not only efficacy but meeting patients' expectations about the potential side effects of the preventative drug selected. Prior to prescribing prophylactic drugs to prophylaxis‐naive migraine patients, we aimed to quantify the acceptance or rejection of some of the possible adverse events associated with migraine prophylactic drugs.Methods.— A total of 203 prophylactic‐naive migraine/chronic migraine patients, 17 (8.4%) male, 186 (91.6%) female, aged 19 to 65 years were serially selected and asked to answer bidirectional visual numerical scales designed for this purpose, with 1 scale for each side effect. The question posed was: “How much would you accept or reject the following side effects to get rid of your migraine headaches?” The side effects listed were dry mouth, epigastric burning, low energy, tingling, somnolence, depression, tremor, insomnia, memory loss, sluggishness, weight gain, and weight loss.Results.— The most rejected possible side effects were weight gain, memory loss, and depression. Weight loss was better accepted by patients with a higher body mass. In general, there was a higher acceptance of side effects for patients taking more than 10 symptomatic medications a month, especially for loss of energy and somnolence. Older patients lacked an acceptance of tremor.Conclusion.— Our findings reinforce and quantify findings similar to those in the literature, and provide new data regarding the preference determinants for prophylactic medication.
Prevalence of Headache in the Entire Population of a Small City in Brazil
Authors: Junior Ariovaldo S. , Krymchantowski Abouch , Moreira Pedro , Vasconcelos Luiz , Gomez Rodrigo , Teixeira Antonio 
Published: April 2009

Objective.— To estimate the 1‐year prevalence of headache, using face‐to‐face interviews of the entire population of a city in Brazil.Methods.— This was a cross‐sectional, population‐based study. We conducted face‐to‐face interviews of all individuals older than 10 years, in a town (Capela Nova) in Brazil. Prevalence of the headache was estimated using prevalence ratios, adjusted by gender, age, marital status, and level education.Results.— The estimated 1‐year prevalence of any headache was 65.4%. Headache was 1.5 times more prevalent in women and individuals aged 20 and 29, but less prevalent in the elderly and divorced. There was not association with the level of education.Conclusions.— From a public healthcare perspective, headache should be seen as hypertension and diabetes, and actively screened and treated.
Clinical Relevance of a Raised Plasma N‐Terminal Pro‐Brain Natriuretic Peptide Level in a Population‐Based Cohort of Nonagenarians
Authors: Vaes Bert , De Ruijter Wouter , Degryse Jan , Westendorp Rudi G. J. , Gussekloo Jacobijn 
Published: April 2009

OBJECTIVES: To investigate whether plasma N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) remains a specific marker of cardiac illness in very old age and can be used to identify very elderly people at high risk for death independent of the presence of known cardiac diagnoses.DESIGN: Prospective, observational, population‐based follow‐up study within the Leiden 85‐Plus Study of a 2‐year birth cohort (1912–1914).SETTING: General population, municipality of Leiden, the Netherlands.PARTICIPANTS: Two hundred seventy‐four participants were followed up from age 90 onward (median follow‐up 42.3 months, interquartile range 20.2–50.2 months).MEASUREMENTS: Plasma NT‐proBNP level, indicators of general health and functioning, and specific cardiac diagnoses at age 90 and mortality from age 90 onward.RESULTS: Plasma levels of NT‐proBNP were not correlated with indicators of poor health or poor functioning, but the level of NT‐proBNP increased significantly with increasing numbers of cardiac diagnoses (P<.001). High NT‐proBNP was associated with overall mortality in participants with (hazard ratio (HR)=2.8, 95% confidence interval (CI)=1.5–5.2) and without (HR=3.5, 95% CI=1.6–7.5) specific cardiac diagnoses. This was also found for cardiovascular mortality risks (with specific cardiac diagnoses HR=4.1, 95% CI=1.5–11 vs without HR=5.6, 95% CI=1.0–30) and noncardiovascular mortality risks (with specific cardiac diagnoses HR=1.9, 95% CI=0.84–4.5 vs without HR=3.4, 95% CI=1.3–8.6).CONCLUSION: Plasma NT‐proBNP is a disease‐specific marker of cardiac illness in nonagenarians and can possibly be used as a predictor of mortality in elderly people with and without specific cardiac diagnoses.
The value of automated gel column agglutination technology in the identification of true inherited D blood types in massively transfused patients
Authors: Summers Jr Thomas , Johnson Viviana V. , Stephan John P. , Johnson Gloria J. , Leonard George 
Published: April 2009

BACKGROUND: Massive transfusion of D− trauma patients in the combat setting involves the use of D+ red blood cells (RBCs) or whole blood along with suboptimal pretransfusion test result documentation. This presents challenges to the transfusion service of tertiary care military hospitals who ultimately receive these casualties because initial D typing results may only reflect the transfused RBCs. After patients are stabilized, mixed‐field reaction results on D typing indicate the patient's true inherited D phenotype. This case series illustrates the utility of automated gel column agglutination in detecting mixed‐field reactions in these patients.STUDY DESIGN AND METHODS: The transfusion service test results, including the automated gel column agglutination D typing results, of four massively transfused D− patients transfused D+ RBCs is presented. To test the sensitivity of the automated gel column agglutination method in detecting mixed‐field agglutination reactions, a comparative analysis of three automated technologies using predetermined mixtures of D+ and D− RBCs is also presented.RESULTS: The automated gel column agglutination method detected mixed‐field agglutination in D typing in all four patients and in the three prepared control specimens. The automated microwell tube method identified one of the three prepared control specimens as indeterminate, which was subsequently manually confirmed as a mixed‐field reaction. The automated solid‐phase method was unable to detect any mixed fields.CONCLUSION: The automated gel column agglutination method provides a sensitive means for detecting mixed‐field agglutination reactions in the determination of the true inherited D phenotype of combat casualties transfused massive amounts of D+ RBCs.
Effects of storage and leukoreduction on lymphocytes and Epstein‐Barr virus genomes in platelet concentrates
Authors: Qu Lirong , Rowe David T. , Donnenberg Albert D. , Griffin Deborah L. , Triulzi Darrell J. 
Published: April 2009

BACKGROUND: Epstein‐Barr virus (EBV) persists in infected B lymphocytes in blood donors. Lymphocytes are viable during platelet (PLT) storage. The effects of storage and leukoreduction on lymphocytes and EBV genomes are evaluated.STUDY DESIGN AND METHODS: Forty nonleukoreduced PLT concentrates were stored at 20 to 24°C for up to 7 days. EBV genomes in B cells were quantified on Days 1 and 5. Viable white blood cells (WBCs) and T and B cells were quantified in 10 of 40 units on Days 1, 3, 5, and 7 of storage. For the leukoreduction study, four pools of PLTs were leukoreduced within 24 hours of collection. B cells from before leukoreduction and all peripheral blood mononuclear cells from after leukoreduction were assayed for EBV.RESULTS: Viable WBCs and T cells were stable whereas viable B cells were reduced to 71% of the Day 1 level by Day 5. A total of 31 of 37 (83.8%) units were EBV positive. Although EBV genomes remained stable in most units, 12 of 37 units demonstrated a median of 5.1 (range 2‐ to 134)‐fold increase in EBV genomes per 105 B cells on Day 5. For the leukoreduction study, EBV genomes were detected in four of four pools before leukoreduction with a median of 3.8 (range, 0.2‐93.6) EBV genomes per 105 B cells. EBV genomes were not detected in any of the postleukoreduction specimens.CONCLUSIONS: Seventy percent of B lymphocytes are viable on Day 5 of PLT storage. Although the mean number of EBV genomes remained stable, a subset of units had increased EBV genomes during storage. Leukoreduction removed polymerase chain reaction–detectable EBV genomes from PLT pools.
Rey Visual Design Learning Test performance correlates with white matter structure
Authors: Begré Stefan , Kiefer Claus , von Känel Roland , Frommer Angela , Federspiel Andrea 
Published: April 2009

Objective:Studies exploring relation of visual memory to white matter are extensively lacking. The Rey Visual Design Learning Test (RVDLT) is an elementary motion, colour and word independent visual memory test. It avoids a significant contribution from as many additional higher order visual brain functions as possible to visual performance, such as three-dimensional, colour, motion or word-dependent brain operations. Based on previous results, we hypothesised that test performance would be related with white matter of dorsal hippocampal commissure, corpus callosum, posterior cingulate, superior longitudinal fascicle and internal capsule.Methods:In 14 healthy subjects, we measured intervoxel coherence (IC) by diffusion tensor imaging as an indication of connectivity and visual memory performance measured by the RVDLT. IC considers the orientation of the adjacent voxels and has a better signal-to-noise ratio than the commonly used fractional anisotropy index.Results:Using voxelwise linear regression analyses of the IC values, we found a significant and direct relationship between 11 clusters and visual memory test performance. The fact that memory performance correlated with white matter structure in left and right dorsal hippocampal commissure, left and right posterior cingulate, right callosal splenium, left and right superior longitudinal fascicle, right medial orbitofrontal region, left anterior cingulate, and left and right anterior limb of internal capsule emphasises our hypothesis.Conclusion:Our observations in healthy subjects suggest that individual differences in brain function related to the performance of a task of higher cognitive demands might partially be associated with structural variation of white matter regions.
Pleuropulmonary complications of PVL‐positive Staphylococcus aureus infection in children
Authors: Thomas Biju , Pugalenthi Arun , Chilvers Mark 
Published: April 2009

AbstractIt is increasingly recognized world‐wide that Panton‐Valentine leukocidin (PVL)‐positive Staphylococcus aureus (PVL‐SA) is associated with a highly aggressive and often fatal form of community‐acquired pneumonia. We report four children who presented with severe pleuropulmonary complications due to infection by community‐acquired methicillin‐sensitive S. aureus (CA‐MSSA), producing PVL toxin. The complications included bilateral multilobular infiltrates, pneumatocoeles, recurrent pneumothoraces, pleural effusion, empyema, lung abscess and diaphragmatic paralysis. This case series highlights the diverse pleuropulmonary manifestations of this potentially lethal infection and the importance of heightened awareness, early recognition and aggressive therapy.Conclusion:  Complicated pneumonia in a previously fit young patient with a history of preceding ‘flu‐like’ illness or skin/soft tissue infection should raise the suspicion of infection by PVL‐positive Staphylococcus aureus (PVL‐SA). Severe pleuropulmonary complications are a feature of this disease.
Initial Stability of Two Dental Implant Systems: Influence of Buccolingual Width and Probe Orientation on Resonance Frequency Measurements
Authors: Tözüm Tolga F. , Turkyilmaz Ilser , Bal Bilge Turhan 
Published: April 2009

ABSTRACTBackground: Although many factors seem to have an impact on the resonance frequency (RF) values of implants, there is a lack of evidence about some other parameters, which may have an influence on implant stability.Purpose: The aims of the study were to determine whether initial stability of a dental implant differs when the buccolingual width of the bone changes, to determine whether different orientations affect the RF measurements in the RF device, and to investigate two dental implants with different morphologies with regard to their initial stability.Materials and Methods: Two implant systems (Tidal Spiral Dental Implant Systems, Huntsville, AL, USA, and MIS Seven, MIS Implants Technologies Ltd., Shlomi, Israel) with diameters of 3.75 mm and 4.2 mm and with a length of 13 mm were used. Following the insertion of implants, buccolingual thinning of the models was performed in 2‐mm increments ranging between 0 and 8 mm.Results: A statistically significant decrease for implant stability quotient (ISQ) values was noticed for both diameters and both systems for all dimensional time points of the blocks (p < .05). The second system (more number of threads) resulted with higher ISQ values for both diameters than the first system (lower number of threads) (p < .001). The orientation of the probe influenced the measurements, where a standard orientation is advisable for the magnetic RF device.Conclusion: Different implant surface geometries seem to behave in different patterns in terms of initial stability. Dimensional changes in buccolingual direction seem to have an impact on the initial stability, where wider implants also presented higher ISQ values than narrow ones.
Cholesterol Granuloma of the Maxillary Sinus Encountered during Floor Augmentation Procedure: A Case Report
Authors: Karaky Ashraf Abu , Sawair Faleh A. , Baqain Zaid H. , Hassona Yazan , Khraisat Ameen 
Published: April 2009

ABSTRACTBackground: Cholesterol granuloma (CG) is a foreign‐body reaction to the deposition of cholesterol crystals. Its occurrence in the paranasal sinuses is very rare.Purpose: This report describes a new case of maxillary sinus CG discovered incidentally during sinus‐floor augmentation for dental implant placement in a 60‐year‐old female patient.Materials and Methods: The preoperative clinical and radiological examinations revealed a normal maxillary antrum with no evidence of sinus pathology. After lateral osteotomy, a dark‐green, viscous soft tissue mass appeared through the thin mucous membrane inside the sinus. Enucleation and curettage of the sinus contents including the sinus membrane were performed for histopathologic analysis. The augmentation and implant placement procedures were postponed.Results: Histopathologic analysis showed several fragments of granulation tissue containing diffuse cholesterol clefts surrounded by mixed chronic inflammatory cell infiltrate including plasma cells and lymphocytes. These features were compatible with the diagnosis of CG. The patient was followed up for 3 months after the first procedure, and a second attempt of sinus augmentation and dental implant insertion was then carried out. The inserted dental implants were followed up for 6 months without any complications.Conclusions: CG of maxillary sinus can be an incidental finding. For this reason, the final diagnosis can only be achieved after examination of the material under the microscope.
Precision of Fit to Implants: A Comparison of Cresco™ and Procera® Implant Bridge Frameworks
Authors: Hjalmarsson Lars , Örtorp Anders , Smedberg Jan‐Ivan , Jemt Torsten 
Published: April 2009

ABSTRACTBackground: The Cresco™ (Astra Tech AB, Mölndal, Sweden) method aims to reduce the inevitable distortions when cast metal frameworks for implant‐supported prostheses are fabricated. However, limited data are available for the precision of fit for this method.Purpose: To measure and compare the precision of fit of Cresco‐ and computer numeric controlled (CNC)‐milled metal frameworks for implant‐supported fixed complete prostheses.Materials and Methods: Two groups of frameworks were fabricated according to the Cresco method, either in titanium (Cresco‐Ti, n = 10) or in a cobalt‐chrome alloy (Cresco‐CoCr, n = 10). A third group comprised CNC‐milled titanium frameworks (Procera® Implant Bridge [PIB], Nobel Biocare AB, Göteborg, Sweden), made from individual model/pattern measurements (PIB, n = 5). Measurements of fit were performed by means of a coordinate measuring machine linked to a computer. The collected data on distortions were analyzed.Results: Overall, a maximal three‐dimensional range of center point distortion of 279 µm was observed for measured frameworks. The framework width (x‐axis) decreased for Cresco‐CoCr, but increased in Cresco‐Ti and PIB; Cresco‐CoCr compared to Cresco‐Ti (p = .0002) and Cresco‐CoCr compared to PIB (p < .0001). In vertical dimension (z‐axis), less distortions were present in PIB compared to Cresco‐CoCr (p = .0007) and in PIB compared to Cresco‐Ti (p < .0001).Conclusions: None of the frameworks presented a perfect, completely “passive fit” to the master. Although the direction of distortions varied, the horizontal distortions were of similar magnitudes. However, the PIB frameworks had statistical significant less vertical distortions as compared to the Cresco groups.
Quantitation of Mandibular Ramus Volume as a Source of Bone Grafting
Authors: Verdugo Fernando , Simonian Krikor , McDonald Roberto Smith , Nowzari Hessam 
Published: April 2009

ABSTRACTBackground: When alveolar atrophy impairs dental implant placement, ridge augmentation using mandibular ramus graft may be considered. In live patients, however, an accurate calculation of the amount of bone that can be safely harvested from the ramus has not been reported. The use of a software program to perform these calculations can aid in preventing surgical complications.Purpose: The aim of the present study was to intra‐surgically quantify the volume of the ramus bone graft that can be safely harvested in live patients, and compare it to presurgical computerized tomographic calculations.Materials and Methods: The AutoCAD® software program quantified ramus bone graft in 40 consecutive patients from computerized tomographies. Direct intra‐surgical measurements were recorded thereafter and compared to software data (n = 10). In these 10 patients, the bone volume was also measured at the recipient sites 6 months post‐sinus augmentation.Results: The mandibular second and third molar areas provided the thickest cortical graft averaging 2.8 ± 0.6 mm. The thinnest bone was immediately posterior to the third molar (1.9 ± 0.3 mm). The volume of ramus bone graft measured by AutoCAD averaged 0.8 mL (standard deviation [SD] 0.2 mL, range: 0.4–1.2 mL). The volume of bone graft measured intra‐surgically averaged 2.5 mL (SD 0.4 mL, range: 1.8–3.0 mL). The difference between the two measurement methods was significant (p < 0.001). The bone volume measured 6 months post‐sinus augmentation averaged 2.2 mL (SD 0.4 mL, range: 1.6–2.8 mL) with a mean loss of 0.3 mL in volume.Conclusion: The mandibular second molar area provided the thickest cortical graft. A cortical plate of 2.8 mm in average at combined second and third molar areas provided 2.5 mL particulated volume. The use of a design software program can improve surgical treatment planning prior to ramus bone grafting. The AutoCAD software program did not overestimate the volume of bone that can be safely harvested from the mandibular ramus.