bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-screen electronic alerts to augment venous thromboembolism prophylaxis
Authors: Fiumara Karen , Piovella Chiara , Hurwitz Shelley , Piazza Gregory , Niles Clyde , Fanikos John , Paterno Marilyn , Labreche Matthew , Stevens Leslie-Ann , Baroletti Steven , Goldhaber Samuel 
Published: November 2009

SummaryVenous thromboembolism (VTE) prophylaxis in high-risk patients is frequently underutilised. We previously devised a one-screen computer alert program that identified hospitalised patients at high risk for VTE who were not receiving prophylaxis and advised their physicians to prescribe prophylaxis. While this strategy reduced the 90-day incidence of symptomatic VTE by 41%, the majority of electronic alerts were ignored. We have now developed a serial three-screen alert computer program designed to educate physicians who initially declined to order prophylaxis after a single screen alert. Of a total cohort of 880, the responsible physicians for 425 patients received a single electronic alert, whereas 455 who declined prophylaxis after the first screen received the second and third screens of the novel three-screen alert. Our enhanced serial three-screen alert program generated VTE prophylaxis orders for 58.4% of the 455 patients whose physicians initially declined to order prophylaxis following the one-screen alert. There was no significant difference in symptomatic 90-day VTE rates between the two cohorts (2.8% for the one-screen vs. 2.2% for the three-screen, p=0.55). We conclude that our three-screen computer alert program can markedly increase prophylaxis among physicians who decline an initial single screen alert.
Endothelial Progenitor Cells Bind and Inhibit Platelet Function and Thrombus Formation
Authors: Abou-Saleh Haissam , Yacoub Daniel , Théorêt Jean-François , Gillis Marc-Antoine , Neagoe Paul-Eduard , Labarthe Benoit , Théroux Pierre , Sirois Martin G. , Tabrizian Maryam , Thorin Eric , Merhi Yahye 
Published: November 2009

Background—Interactions of endothelial progenitor cells (EPCs) with vascular and blood cells contribute to vascular homeostasis. Although platelets promote the homing of EPCs to sites of vascular injury and their differentiation into endothelial cells, the functional consequences of such interactions on platelets remain unknown. Herein, we addressed the interactions between EPCs and platelets and their impact on platelet function and thrombus formation.Methods and Results—Cultured on fibronectin in conditioned media, human peripheral blood mononuclear cells differentiated, within 10 days of culture, into EPCs, which uptake acetylated low-density lipoprotein, bind ulex-lectin, lack monocyte/leukocyte markers (CD14, P-selectin glycoprotein ligand-1, L-selectin), express progenitor/endothelial markers (CD34, vascular endothelial growth factor receptor-2, von Willebrand factor, and vascular endothelial cadherin), and proliferate in culture. These EPCs bound activated platelets via CD62P and inhibited its translocation, glycoprotein IIb/IIIa activation, aggregation, and adhesion to collagen, mainly via prostacyclin secretion. Indeed, this was associated with upregulation of cyclooxygenase-2 and inducible nitric oxide synthase. However, the effects on platelets in vitro were reversed by cyclooxygenase and cyclooxygenase-2 inhibition but not by nitric oxide or inducible nitric oxide synthase inhibition. Moreover, in a ferric chloride–induced murine arterial thrombosis model, injection of EPCs led to their incorporation into sites of injury and impaired thrombus formation, leading to an incomplete occlusion with 50% residual flow.Conclusions—Peripheral blood mononuclear cell–derived EPCs bind platelets via CD62P and inhibit platelet activation, aggregation, adhesion to collagen, and thrombus formation, predominantly via upregulation of cyclooxygenase-2 and secretion of prostacyclin. These findings add new insights into the biology of EPCs and define their potential roles in regulating platelet function and thrombosis.
Relationship between Lightning Activity over Peninsular India and Sea Surface Temperature
Authors: Tinmaker M. I. R. , Ali Kaushar , Beig G. 
Published: November 2009

AbstractThis paper presents a study of spatiotemporal variation of lightning activity over Peninsular India (8°–22°N, 72°–88°E) by using monthly satellite-based lightning flash grid (1° × 1°) data for a period of 10 yr (1998–2007). The data are examined in terms of spatial, annual, and seasonal distribution of the lightning activity. It is found that lightning activity is higher over south Peninsular India and eastern India. On a seasonal time scale, the lightning activity shows two maxima—first in the month of May and then in the month of September. The lightning activity in the monsoon period is noticed to be considerable because of the occurrence of the low-level jet and increase in the monsoon break period. During the postmonsoon, the activity is mainly due to the presence of the convective nature of the disturbed weather during the northeast monsoon season over most parts of the east coast of south Peninsular India. The relationship between lightning activity over Peninsular India and sea surface temperature in the bordering seas (Arabian Sea and Bay of Bengal) is also examined. The results disclose a significant link between them.
Generation of Infrasound by Evaporating Hydrometeors in a Cloud Model
Authors: Schecter David A. , Nicholls Melville E. 
Published: November 2009

AbstractThe dynamical core of the Regional Atmospheric Modeling System has been tailored to simulate the infrasound of vortex motions and diabatic cloud processes in a convective storm. Earlier studies have shown that the customized model (c-RAMS) adequately simulates the infrasonic emissions of generic vortex oscillations. This paper provides evidence that c-RAMS accurately simulates the infrasound associated with parameterized phase transitions of cloud moisture. Specifically, analytical expressions are derived for the infrasonic emissions of evaporating water droplets in dry and humid environments. The dry analysis considers two single-moment parameterizations of the microphysics, which have distinguishable acoustic signatures. In general, the analytical results agree with the numerical output of the model. An appendix briefly demonstrates the ability of c-RAMS to accurately simulate the infrasound of the entropy and mass sources generated by an equilibrating cloud of icy hydrometeors.
Noah LSM Snow Model Diagnostics and Enhancements
Authors: Livneh Ben , Xia Youlong , Mitchell Kenneth E. , Ek Michael B. , Lettenmaier Dennis P. 
Published: November 2009

Abstract
A negative snow water equivalent (SWE) bias in the snow model of the Noah land surface scheme used in the NCEP suite of numerical weather and climate prediction models has been noted by several investigators. This bias motivated a series of offline tests of model extensions and improvements intended to reduce or eliminate the bias. These improvements consist of changes to the model’s albedo formulation that include a parameterization for snowpack aging, changes to how pack temperature is computed, and inclusion of a provision for refreeze of liquid water in the pack. Less extensive testing was done on the performance of model extensions with alternate areal depletion parameterizations. Model improvements were evaluated through comparisons of point simulations with National Resources Conservation Service (NRCS) Snowpack Telemetry (SNOTEL) SWE data for deep-mountain snowpacks at selected stations in the western United States, as well as simulations of snow areal extent over the conterminous United States (CONUS) domain, compared with observational data from the NOAA Interactive Multisensor Snow and Ice Mapping System (IMS). The combination of snow-albedo decay and liquid-water refreeze results in substantial improvements in the magnitude and timing of peak SWE, as well as increased snow-covered extent at large scales. Modifications to areal snow depletion thresholds yielded more realistic snow-covered albedos at large scales.
Evaluation of GSMaP Precipitation Estimates over the Contiguous United States
Authors: Tian Yudong , Peters-Lidard Christa D. , Adler Robert F. , Kubota Takuji , Ushio Tomoo 
Published: November 2009

Abstract
Precipitation estimates from the Global Satellite Mapping of Precipitation (GSMaP) project are evaluated over the contiguous United States (CONUS) for the period of 2005–06. GSMaP combines precipitation retrievals from the Tropical Rainfall Measuring Mission satellite and other polar-orbiting satellites, and interpolates them with cloud motion vectors derived from infrared images from geostationary satellites, to produce a high-resolution dataset. Four other satellite-based datasets are also evaluated concurrently with GSMaP, to provide a better perspective. The new Climate Prediction Center (CPC) unified gauge analysis is used as the reference data. The evaluation shows that GSMaP does well in capturing the spatial patterns of precipitation, especially for summer, and that it has better estimation of precipitation amount over the eastern than over the western CONUS. Meanwhile, GSMaP shares many of the challenges common to other satellite-based products, including that it underestimates in winter and overestimates in summer. In winter, GSMaP has on average one-half less precipitation over the western region and one-third less over the eastern region, whereas in summer it has about three-quarters and one-quarter more estimated precipitation over the two respective regions, respectively. Most of the summer overestimates (winter underestimates) are from an excessive (insufficient) number of strong events (&gt;20 mm day−1). Overall, GSMaP’s performance is comparable to other satellite-based products, with slightly better probability of detection during summer, and the different satellite-based estimates as a group have better agreement among themselves during summer than during winter.
De la connaissance à la reconnaissance: la retranscription d’entretien comme marqueur social
Authors: Marchand-Lagier Christèle 
Published: November 2009

Cet article analyse les manières de rendre compte d’un échange oral entre un enquêteur et ses enquêtés. Le vote en faveur du Front national, objet politique singulier et stigmatisé, offre la possibilité de mesurer toutes les difficultés que rencontre celui ou celle qui veut témoigner d’une proximité avec son échantillon (au regard du genre et du milieu social). Les retranscriptions d’entretiens placent le chercheur — pris entre l’impératif de la connaissance de ses enquêtés et celui de la reconnaissance académique — dans la délicate position de rendre des comptes sur ce qu’il est. A trop insister sur la place occupée par chacun dans l’espace social, les retranscriptions dévoilent combien tout ce qui peut servir l’échange oral peut desservir la communication écrite sur cet échange. Mots-clés: Communication écrite; Espace social; Front National; Genre; Reconnaissance professionnelle; Retranscription d’entretien
Tracking Our Progress
Authors: Tilbury Daniella 
Published: November 2009

The sustainability agenda is a concern of several UN agencies that appreciate how well-being, social justice, human development and the health of our planet are inextricably linked. This remit underpinned the launch of the UN Decade in Education for Sustainable Development (DESD) in 2005. As the DESD reaches its mid-point, mechanisms for assessing progress towards sustainability through education and learning have been formalised. This paper presents the Global Monitoring and Evaluation Framework (GMEF) which has been adopted by UNESCO to review changes in context structures (cycle I); processes and learning (cycle II) and outcomes and impacts (cycle III) during the DESD. The GMEF draws from the global milestones and major education for sustainable development (ESD) thrusts identified in UNESCO’s International Implementation Scheme. It combines self-reporting, and participatory monitoring and expert evaluation to increase opportunities for engagement as well as to assure representation and validity of data. The paper concludes that the task of assessing global progress in ESD in an ambitious one. It identifies key challenges which will need to be overcome.
Gastric MALT lymphoma B cells express polyreactive, somatically mutated immunoglobulins
Authors: Craig Vanessa J. , Arnold Isabelle , Gerke Christiane , Huynh Minh Q. , Wündisch Thomas , Neubauer Andreas , Renner Christoph , Falkow Stanley , Müller Anne 
Published: November 2009

Abstract
Gastric B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) arises against a background of chronic inflammation caused by persistent Helicobacter pylori infection. The clinical and histopathologic features of the human tumor can be reproduced by Helicobacter infection of BALB/c mice. In this study, we have analyzed the antibody sequences and antigen specificity of a panel of murine and human MALT lymphoma–derived antibodies. We find that a majority of tumors in patients as well as experimentally infected mice are monoclonal. The tumor immunoglobulin heavy chain genes have undergone somatic hypermutation, and approximately half of all tumors show evidence of intraclonal variation and positive and/or negative selective pressure. Recombinantly expressed MALT lymphoma antibodies bind with intermediate affinity to various unrelated self- and foreign antigens, including Helicobacter sonicate, immunoglobulin G (IgG), DNA, and stomach extract; antigen binding is blocked in a dose-dependent manner in competitive enzyme-linked immunosorbent assays. A strong bias toward the use of VH gene segments previously linked to autoantibodies and/or polyreactive antibodies in B-cell malignancies or autoimmune pathologies supports the experimental finding of polyreactivity. Our results suggest that MALT lymphoma development may be facilitated by an array of local self- and foreign antigens, providing direct antigenic stimulation of the tumor cells via their B-cell receptor.
A genome-wide deletion mutant screen identifies pathways affected by nickel sulfate in Saccharomyces cerevisiae
Authors: Arita Adriana , Zhou Xue , Ellen Thomas P , Liu Xin , Bai Jingxiang , Rooney John P , Kurtz Adrienne , Klein Catherine B , Dai Wei , Begley Thomas J , Costa Max 
Published: November 2009

Abstract

Background
The understanding of the biological function, regulation, and cellular interactions of the yeast genome and proteome, along with the high conservation in gene function found between yeast genes and their human homologues, has allowed for Saccharomyces cerevisiae to be used as a model organism to deduce biological processes in human cells. Here, we have completed a systematic screen of the entire set of 4,733 haploid S. cerevisiae gene deletion strains (the entire set of nonessential genes for this organism) to identify gene products that modulate cellular toxicity to nickel sulfate (NiSO4).

Results
We have identified 149 genes whose gene deletion causes sensitivity to NiSO4 and 119 genes whose gene deletion confers resistance. Pathways analysis with proteins whose absence renders cells sensitive and resistant to nickel identified a wide range of cellular processes engaged in the toxicity of S. cerevisiae to NiSO4. Functional categories overrepresented with proteins whose absence renders cells sensitive to NiSO4 include homeostasis of protons, cation transport, transport ATPases, endocytosis, siderophore-iron transport, homeostasis of metal ions, and the diphthamide biosynthesis pathway. Functional categories overrepresented with proteins whose absence renders cells resistant to nickel include functioning and transport of the vacuole and lysosome, protein targeting, sorting, and translocation, intra-Golgi transport, regulation of C-compound and carbohydrate metabolism, transcriptional repression, and chromosome segregation/division. Interactome analysis mapped seven nickel toxicity modulating and ten nickel-resistance networks. Additionally, we studied the degree of sensitivity or resistance of the 111 nickel-sensitive and 72 -resistant strains whose gene deletion product has a similar protein in human cells.

Conclusion
We have undertaken a whole genome approach in order to further understand the mechanism(s) regulating the cell's toxicity to nickel compounds. We have used computational methods to integrate the data and generate global models of the yeast's cellular response to NiSO4. The results of our study shed light on molecular pathways associated with the cellular response of eukaryotic cells to nickel compounds and provide potential implications for further understanding the toxic effects of nickel compounds to human cells.
Analysis of expressed sequence tags and identification of genes encoding cell-wall-degrading enzymes from the fungivorous nematode Aphelenchus avenae
Authors: Karim Nurul , Jones John T , Okada Hiroaki , Kikuchi Taisei 
Published: November 2009

Abstract

Background
The fungivorus nematode, Aphelenchus avenae is widespread in soil and is found in association with decaying plant material. This nematode is also found in association with plants but its ability to cause plant disease remains largely undetermined. The taxonomic position and intermediate lifestyle of A. avenae make it an important model for studying the evolution of plant parasitism within the Nematoda. In addition, the exceptional capacity of this nematode to survive desiccation makes it an important system for study of anhydrobiosis. Expressed sequence tag (EST) analysis may therefore be useful in providing an initial insight into the poorly understood genetic background of A. avenae.

Results
We present the generation, analysis and annotation of over 5,000 ESTs from a mixed-stage A. avenae cDNA library. Clustering of 5,076 high-quality ESTs resulted in a set of 2,700 non-redundant sequences comprising 695 contigs and 2,005 singletons. Comparative analyses indicated that 1,567 (58.0%) of the cluster sequences had homologues in Caenorhabditis elegans, 1,750 (64.8%) in other nematodes, 1,321(48.9%) in organisms other than nematodes, and 862 (31.9%) had no significant match to any sequence in current protein or nucleotide databases. In addition, 1,100 (40.7%) of the sequences were functionally classified using Gene Ontology (GO) hierarchy. Similarity searches of the cluster sequences identified a set of genes with significant homology to genes encoding enzymes that degrade plant or fungal cell walls. The full length sequences of two genes encoding glycosyl hydrolase family 5 (GHF5) cellulases and two pectate lyase genes encoding polysaccharide lyase family 3 (PL3) proteins were identified and characterized.

Conclusion
We have described at least 2,214 putative genes from A. avenae and identified a set of genes encoding a range of cell-wall-degrading enzymes. This EST dataset represents a starting point for studies in a number of different fundamental and applied areas. The presence of genes encoding a battery of cell-wall-degrading enzymes in A. avenae and their similarities with genes from other plant parasitic nematodes suggest that this nematode can act not only as a fungal feeder but also a plant parasite. Further studies on genes encoding cell-wall-degrading enzymes in A. avenae will accelerate our understanding of the complex evolutionary histories of plant parasitism and the use of genes obtained by horizontal gene transfer from prokaryotes.
Effectiveness of IT-based diabetes management interventions: a review of the literature
Authors: Costa Beth M , Fitzgerald Kristine J , Jones Kay M , Dunning AM Trisha 
Published: November 2009

Abstract

Background
Information technology (IT) is increasingly being used in general practice to manage health care including type 2 diabetes. However, there is conflicting evidence about whether IT improves diabetes outcomes. This review of the literature about IT-based diabetes management interventions explores whether methodological issues such as sample characteristics, outcome measures, and mechanisms causing change in the outcome measures could explain some of the inconsistent findings evident in IT-based diabetes management studies.

Methods
Databases were searched using terms related to IT and diabetes management. Articles eligible for review evaluated an IT-based diabetes management intervention in general practice and were published between 1999 and 2009 inclusive in English. Studies that did not include outcome measures were excluded.

Results
Four hundred and twenty-five articles were identified, sixteen met the inclusion criteria: eleven GP focussed and five patient focused interventions were evaluated. Nine were RCTs, five non-randomised control trials, and two single-sample before and after designs. Important sample characteristics such as diabetes type, familiarity with IT, and baseline diabetes knowledge were not addressed in any of the studies reviewed. All studies used HbA1c as a primary outcome measure, and nine reported a significant improvement in mean HbA1c over the study period; only two studies reported the HbA1c assay method. Five studies measured diabetes medications and two measured psychological outcomes. Patient lifestyle variables were not included in any of the studies reviewed. IT was the intervention method considered to effect changes in the outcome measures. Only two studies mentioned alternative possible causal mechanisms.

Conclusion
Several limitations could affect the outcomes of IT-based diabetes management interventions to an unknown degree. These limitations make it difficult to attribute changes solely to such interventions.
Genetic variation in the NBS1, MRE11, RAD50 and BLM genes and susceptibility to non-Hodgkin lymphoma
Authors: Schuetz Johanna M , MacArthur Amy C , Leach Stephen , Lai Agnes S , Gallagher Richard P , Connors Joseph M , Gascoyne Randy D , Spinelli John J , Brooks-Wilson Angela R 
Published: November 2009

AbstractBackgroundTranslocations are hallmarks of non-Hodgkin lymphoma (NHL) genomes. Because lymphoid cell development processes require the creation and repair of double stranded breaks, it is not surprising that disruption of this type of DNA repair can cause cancer. The members of theMRE11-RAD50-NBS1(MRN) complex andBLMhave central roles in maintenance of DNA integrity. Severe mutations in any of these genes cause genetic disorders, some of which are characterized by increased risk of lymphoma.MethodsWe surveyed the genetic variation in these genes in constitutional DNA of NHL patients by means of gene re-sequencing, then conducted genetic association tests for susceptibility to NHL in a population-based collection of 797 NHL cases and 793 controls.Results114 SNPs were discovered in our sequenced samples, 61% of which were novel and not previously reported in dbSNP. Although four variants, two inRAD50and two inNBS1, showed association results suggestive of an effect on NHL, they were not significant after correction for multiple tests.ConclusionThese results suggest an influence ofRAD50andNBS1on susceptibility to diffuse large B-cell lymphoma and marginal zone lymphoma. Larger association and functional studies could confirm such a role.