bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kawasaki disease with a concomitant primary Epstein‐Barr virus infection
Authors: KANEGANE HIROKAZU , TSUJI TAKAO , SEKI HIDETOSHI , YACHIE AKIHIRO , YOKOI TOHRU , MIYAWAKI TOSHIO , TANIGUCHI NOBORU 
Published: January 2011

AbstractA two year old boy exhibited not only clinical manifestations which suggested a recurrence of Kawasaki disease (KD) but also evidence of a primary infection by Epstein‐Barr virus (EBV) including tonsillitis, splenomegaly and atypical lymphocytosis in the peripheral blood. An inverted CD4/CD8 ratio in lymphocyte subsets suggested the presence of infectious mononucleosis (IM). Epstein‐Barr virus titers (viral capsid antigen‐immunoglobulin G 1:20; Epstein‐Barr virus‐associated nuclear antigen < 1:10) showed an acute EBV infection and the presence of EBV genome in the blood was determined by the polymerase chain reaction technique. In Japan, the peak incidence of KD and IM is in children under 4 years of age. From the investigation of EBV titers, it has been reported that some patients with KD develop an associated, unusual primary EBV infection. Kawasaki disease concurrent with a primary EBV infection as in this case, suggests the possibility of an etiologic agent related to the KD rather than to the EBV infection itself.
A case of tetrasomy 9p
Authors: ANDOU RURIKO , MIMAKI TAKASHI , OGIHARA TOHRU , TAMAI HIROSHI , MINO MAKOTO 
Published: January 2011

AbstractA case of mosaic 9p tetrasomy (46,XX/47,XX, + dic[9] [q21]) is reported. Clinical manifestations of the patient were generalized hypotonia, severe mental retardation and characteristic dysmorphic features of 9p tetrasomy. A brief review of the literature is also included.
Analysis of seven pedigrees of childhood Wilson's disease characterized by abdominal symptoms
Authors: IKEI NOBUHIRO , ABE JUN , SHIN SADAHITO , KOHSAKA TAKAO 
Published: January 2011

AbstractIn a survey of childhood Wilson's disease (WD) characterized by abdominal symptoms, three patients with high levels of immunologically detectable ceruloplasmin (CP) in serum were found. These three cases were compared with typical cases of WD in which serum CP level was low. In order to clarify the cause of WD, serum CP levels were quantified by two methods, an immunological protein assay and an oxidase activity assay. Using the results of these two assays, WD cases were classified into three groups on the basis of CP content; the first group consisted of patients with low enzyme activity and low CP protein content, the second group consisted of patients with low enzyme activity and normal CP protein content, and the third group, those patients with normal enzyme activity and normal CP protein content. No significant difference in symptoms was observed between these three groups. Since relatively high levels of CP were detected in some WD patients, genetic variation in CP in WD patients was examined by restriction enzyme fragment length polymorphism analysis using CP cDNA. However, no large deletion in the CP gene was detected. Using four types of gene probes for chromosome 13 known to be related to WD, the DNA of WD patients was examined in a similar fashion, but no significant difference was observed between the groups.
Unique form of rickets with low serum 25‐hydroxyvitamin D in two normally nourished children
Authors: ASAMI TADASHI , KAWASAKI TAKUYA , UCHIYAMA MAKOTO 
Published: January 2011

AbstractWe present an unusual type of rickets involving two children: a 2 year old boy and a 15 month old boy, who presented with marked bowing of the lower extremities and bulging of costochondral junctions. Both children had normal growth, with their height and body weight greater than the 50th and 97th percentile for age. Roentgenograms of their extremities showed the typical changes of vitamin D refractory rickets. Serum alkaline phosphatase levels were elevated and serum levels of calcium and phosphate were both within the normal range. No primary cause for the rickets, including nutritional deficiencies, was found in the two patients. Characteristic findings were persistently low serum 25‐hydroxyvitamin D (25‐OH‐D) and normal 1,25‐dihydroxyvitamin D (1,25‐(OH)2‐D). Improvements in clinical and X‐ray findings were observed after either oral administration of 1 α‐(OH)‐D3 (9–15 μg per day) or massive vitamin D2 therapy (600 000 IU single injection). The low serum levels of 25‐OH‐D did not increase unless massive vitamin D2 therapy was also given. These two cases represent a unique form of rickets that does not meet the criteria for any type of previously known rickets.
Mononucleosis‐like illness in an infant associated with human herpesvirus 6 infection
Authors: KANEGANE CHIHARU , KATAYAMA KEITA , KYOUTANI SEIZO , KANEGANE HIROKAZU , SHINTANI NAOHISA , MIYAWAKI TOSHIO , TANIGUCHI NOBORU 
Published: January 2011

AbstractIllnesses resembling mononucleosis, hematologically characterized by atypical lymphocytosis in the peripheral blood, are caused by other viral infections as well as by a primary Epstein‐Barr virus infection. Human herpesvirus 6, a newly isolated member of the herpesvirus group, can also cause a mononucleosis‐like illness. Illness associated with human herpesvirus 6 infection mostly occurs in immunocompetent adults. We observed a 3 month old infant who presented with marked atypical lymphocytosis and liver dysfunction. We examined serum samples to detect viral antibodies related to mononucleosis‐like illness. Only the titers of antibody against human herpesvirus 6 were elevated. Primary human herpesvirus 6 infection cannot only cause exanthem subitum or present in an inapparent form but can also cause an illness like mononucleosis, even in an infant.
Child abuse and child abuse studies in Japan
Authors: IKEDA YOSHIKO 
Published: January 2011

AbstractMedical research on child abuse has a short history of only 20 years. However, the social and familial changes that have occurred since the Second World War have resulted in an increasing number of abused children throughout Japan. Reported cases represent only the tip of the iceberg, with many cases being ignored. This article discusses the history, definition, incidence, and social, familial, and psychopathology factors in the etiology of child abuse based on clinical experience and research surveys undertaken during the past 20 years. Suggestions for improving child abuse preventive and reactive services are also made.
Early intervention in case of child abuse: Co‐operation between the hot‐line and local facilities
Authors: SAITO SATORU 
Published: January 2011

AbstractThe Center for Child Abuse Prevention (CCAP), a citizens' organization, was started in May 1991 with such members as pediatricians, psychiatrists, lawyers and people working at child welfare offices. A hotline dealing with child abuse was set up immediately after the establishment of CCAP on 20 May 1991, and in the 2 years it has been in operation this hot‐line has received 3189 calls out of which we picked 30 cases that CCAP was consulted about by helping persons or therapists affiliated with such facilities as hospitals, public health centers, etc. in order to evaluate how CCAP co‐operates with these organizations.We reviewed the CCAP records of these 30 cases, comparing them with the materials concerning other hot‐line calls, while at the same time interviewing the helping persons and therapists who had called in those cases, ascertaining their motives and the later course of the cases. This follow‐up study was begun in June 1992 so that the longest follow‐up period from the first call was 2 years and 7 months and the shortest 7 months.A total of 73.3% of these 30 cases required emergency intervention, and 53.4% were extremely severe, life‐threatening cases of child abuse. The age distribution of these 30 victimized children peaked between 4 and 6, and 13 and 15 years. The perpetrator was the biological mother in 55.9% of the cases, the biological father in 29.4% and the stepfather in 8.9%. The abuse was physical in 58.3% of the cases, sexual in 8.9%, emotional in 5.6%, and involved neglect in 22.2%. These percentages differ from the general trend seen in the total hot‐line cases, but were very similar to those reported by the Child Guidance Center. In the majority (56.7%) of the cases CCAP was consulted about, CCAP went beyond its hot‐line service and co‐operated to intervene, organizing network sessions in which the helping persons and therapists involved could discuss how best to deal with the problem at hand in five of these cases. In 22 of these 30 cases, the persons involved are still co‐operating with CCAP after successful intervention through which the victimized children were rescued from critical situations.It is vitally important to set up networks between the professionals of the various support agencies involved if we are to intervene successfully in cases of child abuse. Indeed, one should only proceed with the intervention once the various facilities involved have agreed on who should take care of therapy and/or care, and on how to proceed and at what pace.
Immunological unresponsiveness and apoptotic cell death of T cells in measles virus infection
Authors: ADDAE MICHAEL MARK , KOMADA YOSHIHIRO , ZHANG XAO‐LI , SAKURAI MINORU 
Published: January 2011

AbstractThe phenotypic alterations associated with T cells during measles virus infection have been demonstrated and an attempt has been made to show programmed cell death (PCD) of T cells activated in vivo. During the acute phase of illness, activated T cells increased rapidly. Memory T cells (CD45RO+), especially CD8+ memory T cells also tend to increase. During the recovery phase, CD8+ T cells declined rapidly, and naive (CD45RA+) T cells increased in numbers. The anti‐CD3 monoclonal antibody‐induced expression of interleukin‐2 receptor (CD25) was suppressed. However, the addition of phorbol 12‐myristate 13‐acetate (PMA) caused the significant recovery of CD25 expression. In addition, PCD of activated T cells from measles patients was induced in culture. After triggering of the T cell receptor‐CD3 complex, cells became more susceptible to PCD. Interestingly, the addition of PMA could inhibit PCD of activated T cells. Taken together, these data suggest unresponsiveness and activation‐induced cell death of T cells during the primary response to measles virus antigens, depending on the activation status of protein kinase C.
Autoantibodies and CD5+ B cells in childhood onset immune thrombocytopenic purpura
Authors: IYORI HIDEAKI , FUJISAWA KOHJI , AKATSUKA JUN‐ICHI 
Published: January 2011

AbstractWe evaluated platelet associated immunoglobulin (PaIg) G, PaIgM, platelet associated autoantibodies to platelet glycoprotein IIb/IIIa (Pa‐GPIIb/IIIa), the percentage of CD5+ B cells and the amount of platelet‐bound anti‐GPIIb/IIIa monoclonal antibody (mAb) in the peripheral blood of 29 patients with childhood onset chronic immune thrombocytopenic purpura (c‐ITP). The percentage of CD5+ B cells ranged from 2 to 8% (4.7 ± 2.0) in control patients and 1 to 18% (6.2 ± 4.2) in the ITP patients. There was no overall significant difference between the two groups, but the percentage of CD5+ B cells in six of the ITP patients was higher than the mean + 2 s.d. of the controls. There was a significant correlation between the percentage of CD5+ B cells and PaIgM (y = 1.73x + 13.4, r = 0.40, P < 0.05). This finding is the basis for the speculation that CD5+ B cells may play an important role in the production of PaIgM in vivo. There was no correlation between the amounts of PaIgG and Pa‐GPIIb/IIIa. This suggests that the amount of PaIgG does not accurately reflect of the amount of Pa‐GPIIb/IIIa. Furthermore, we have demonstrated that autoantibodies to GPIIb/IIIa are directed to more than one epitope.
Association of empty sella and neuroendocrine disorders in childhood
Authors: AKÇURIN SEMA , ÖCAL GÖNUL , BERBEROǦLU MERIH , MEMIOǦLU NIHAL 
Published: January 2011

AbstractEmpty sella syndrome (ESS) is a multicausal entity. The incidence of primary empty sella syndrome (PESS) in children with neuroendocrine dysfunction is not known. In the pediatric age group, frequency seems to have been underestimated. A total of 117 cases of neuroendocrine disorders, including complete growth hormone deficiency, primary hypothyroidism with pituitary resistance to thyroid hormone, obesity, central precocious puberty, hypothalamic hypogonadism and central diabetes insipidus, have been studied with computed tomography and/or magnetic resonance imaging of sellar region for etiologic evaluation. Twenty‐one patients were found to have PESS. We noted a high incidence of PESS in children with neuroendocrine dysfunction (17.9%). Children with neuroendocrine dysfunction should be investigated with respect to PESS, and children with PESS recognized coincidentally should be studied with the particular consideration of subclinical neuroendocrine dysfunction.
Effect of valproate and carbamazepine on visual evoked potentials in epileptic children
Authors: YÜKSEL ADNAN , ŞARSLAN OSMAN , DEVRANOǦLU KAZIM , DİRİCAN AHMET , HATTAT NEŞE , CENANİ ASIM , YALÇIN ERDİNÇ 
Published: January 2011

AbstractThe effects of carbamazepine (CBZ) and sodium valproate (SV) monotherapy on visual evoked potentials (VEP) were studied in 18 epileptic children receiving CBZ and nine epileptic children receiving SV. Pattern reversal VEP were determined before the administration of antiepileptic drugs (AED) and 1 year later during which time the patients had received AED. The VEP amplitude showed no consistent changes after 1 year of CBZ and SV therapy, but VEP P‐100 latencies were significantly prolonged after 1 year of CBZ therapy. We conclude that CBZ causes a slowing down of central impulse conduction and that VEP is useful to evaluate the effects of AED within the central nervous system.
Hemolytic anemia following high‐dose intravenous immunoglobulin administration
Authors: TAMADA KOH‐ICHI , KOHGA MASATOSHI , MASUDA HIDEKO , HATTORI KAZUMI 
Published: January 2011

AbstractWe describe two cases of hemolytic anemia following high‐dose intravenous human immunoglobulin administration in young females with idiopathic thrombocytopenic purpura. Inducement of hemolytic anemia by anti‐A and anti‐B antibodies in these cases necessitates the performance of a minor crossmatching procedure prior to immunoglobulin use to prevent the occurrence of this adverse reaction.
Neonatal alloimmune thrombocytopenia involving HPA‐5b (Bra): A rare Japanese Case
Authors: SUDA HIDETOSHI , OHTO HITOSHI , TOHYAMA YURIKO , MORITA SHOJI , ISHIJIMA AYAKO , ISHIKAWA KEN , CHIDA SHOICHI , MATSUDA ISAO 
Published: January 2011

AbstractNeonatal alloimmune thrombocytopenia (NAIT) is caused by platelet antigen incompatibility between the mother and fetus. The frequency of NAIT varies among ethnic groups. In Caucasians, HPA‐5b (Bra) is the antigen that is second most frequently implicated. In Japan, NAIT due to anti‐HPA‐5b antibody is quite rare. The present case is the second case of Bra‐NAIT in Japanese and the first case serologically confirmed by monoclonal antibody‐specific immobilization of platelet antigens.
Paroxysmal kinesigenic choreoathetosis associated with prenatal brain damage
Authors: HAMANO SHIN‐ICHIRO , TANAKA YOSHIKO , NARA TAKAHIRO , NAKANISHI YOUKO , SHIMIZU MASAKI 
Published: January 2011

AbstractWe describe a 15 year old patient with paroxysmal kinesigenic choreoathetosis. Neurological examinations revealed a paresis of the right arm and hand that was similar to ulnar nerve palsy, a right homonymous hemianopsia and an ocular movement disturbance of smooth pursuit to left. Attacks of dystonic spasms began abruptly, usually following running, and lasted less than 5 min. Magnetic resonance imaging displayed a linear area of increased signal in the T2‐weighted images along the lateral margin of the left putamen, atrophies of the frontal and temporal opercula and a large porencephalic cyst in the left parieto‐temporo‐occipital region. A cerebral blood flow study with single photon emission computed tomography showed hypoperfusion of the lenticular nucleus and the regions corresponding to the atrophies and the porencephalic cyst. Electroencephalograms during the attacks could not demonstrate epileptic abnormality. Only the neuronal plasticity of an immature brain could explain the discrepancy between the observed huge lesions of the brain and the minor neurological symptoms present. Attacks of paroxysmal kinesigenic choreoathetosis might occur when the basal ganglia maturate to some extent, even if the lesions in the brain were caused before birth.
Inhaled nitric oxide therapy for persistent pulmonary hypertension of the newborn
Authors: FINEMAN JEFFREY R , ZWASS MAURICE S 
Published: January 2011

AbstractIncreasing evidence suggests that the pulmonary vascular endothelium is an important mediator of resting pulmonary vascular tone through the synthesis and release of a variety of vasoactive substances including nitric oxide (NO). In addition, pulmonary endothelial dysfunction (such as impairment of NO synthesis) is present in lung injury and may contribute to the pathophysiology of pulmonary hypertensive disorders. Recently, exogenously administered NO gas has been utilized to treat infants with persistent pulmonary hypertension of the newborn (PPHN). These preliminary studies suggest that inhaled NO is a promising new therapy for the treatment of infants with PPHN. Controlled clinical trials must now be performed to determine if the use of inhaled NO improves the long‐term outcome of patients with PPHN. Long‐term exposure must be monitored closely for potential toxicity which includes methemoglobinemia and lung injury secondary to peroxynitrite and nitrogen dioxide production.
Long‐term prognosis and prognostic factors of Japanese children with mesangial proliferative glomerulonephritis without IgA deposition
Authors: KAKU YOSHITSUGU , HISANO SATOSHI , YAMANE ICHIRO , HATAE KEN , UEDA KOHJI , SUEISHI KATSUO 
Published: January 2011

AbstractMesangial proliferative glomerulonephritis without IgA deposition (non‐IgA MesPGN) is commonly detected in biopsy specimens, but the clinicopathological correlation with the long‐term prognosis still remains obscure. The aim of our study is to elucidate the long‐term prognosis and the clinicopathological prognostic factors in patients with non‐IgA MesPGN. We mailed questionnaires to 122 patients with primary glomerulonephritis who were biopsied between 1963 and 1975. Information was obtained from 109 of these 122 patients and 55 were histologically rediagnosed as having non‐IgA MesPGN. The histological alterations of glomeruli and tubulointerstitium were classified into five grades. The mean period between the biopsy and the questionnaires was 20.5 years. Six of the 55 patients with non‐IgA MesPGN developed end‐stage renal failure and histopathological alterations of renal biopsies from these six patients were classified into grade IV or V. The presence of hypertension, heavy proteinuria of over 2 + or renal insufficiency at the biopsy was related to the severe histological changes, a grade of IV or V and to a poor prognosis. The renal survival rate of all the 55 patients was 88.3% at 20 years after the biopsy, while that of the 12 patients with severe histological changes was 48.6%. Although non‐IgA MesPGN is considered to be a heterogeneous disease, we cannot ignore the incidence of this disease and thus consider it to be one of the important primary glomerulonephritides that occur in childhood.
The first report of a patient with interrupted inferior vena cava, multiple post‐renal veins and azygos‐hemiazygos continuation
Authors: MATSUOKA SUGURU , ANTONIOU EMMANUEL EH , MORI KAZUHIRO , HAYABUCHI YASUNOBU , KURODA YASUHIRO 
Published: January 2011

AbstractThe first case of a patient with interrupted inferior vena cava, four post‐renal veins and an azygoshemiazygos continuation is presented. The complicated anomalies were omphalocele and atrial septal defect. Cine‐magnetic resonance imaging and cardiac catheterization showed an anomalous retroaortic left innominate vein, azygos‐hemiazygos continuation in the prerenal portion, arch formed renal vein in the renal portion and four embryonic vessels in the post‐renal portion.Combination of these anomalies in the major venous system suggested that the inferior vena cava had failed to form and that the bilateral embryonic venous system, postcardinal and supracardinal veins persisted to be the systemic venous channels.
Advanced atrioventricular block associated with atrial tachycardia caused by Mycoplasma pneumoniae infection
Authors: UMEMOTO MASAKAZU , FUJII ISAO , TAKE HIROMICHI 
Published: January 2011

AbstractAtrial tachycardia with atrioventricular (AV) block has been recognized as a common manifestation of digitalis toxicity. We describe here an unusual case of transient advanced AV block associated with atrial tachycardia in a 6 year old boy with evidence of Mycoplasma pneumoniae infection.
Application of a new perchloric acid treatment method to measure endotoxin by an endotoxin‐specific chromogenic Limulus test in neonatal septicemia
Authors: SUDA HIDETOSHI , MOROI CHIKAE , INADA KATSUYA , CHIDA SHOICHI , FUJIWARA TETSURO , YOSHIDA MASAO 
Published: January 2011

AbstractThe endotoxin in blood was measured to establish both the cut‐off value and to detect Gram‐negative septicemia. We employed a new perchloric acid treatment method using an endotoxin‐specific chromogenic Limulus test (Endospecy test). The cut‐off value of endotoxin in blood was 11.2 pg/mL. All cases of septicemia (n = 7) showed high values of endotoxin. Three cases were Group B streptococci, and two cases were Escherichia coli. The others were showed to be negative in blood cultures. The paired values of endotoxin titers during a 48 h interval were useful to evaluate the effectiveness of antibiotics.
Early detection of cutaneous microcirculatory change during hemorrhage using a laser Doppler flowmetry
Authors: TAKAYANAGI TOSHIMITSU , FUKUDA MASAFUMI , TSUJI YOSHIROU , NAKAZAWA MAKOTO 
Published: January 2011

AbstractThe purpose of the present study was to evaluate the usefulness of cutaneous microcirculatory monitoring during hemorrhage. We observed changes in cutaneous blood volume, velocity and flow of five adult rabbits during hemorrhage by using a laser Doppler flowmetry. Mean arterial blood pressure, heart rate and blood gas values were measured.Cutaneous blood volume, velocity and flow decreased significantly after drawing 10 mL/kg of blood, while heart rate, mean arterial blood pressure and blood gas did not change. The decrease of cutaneous blood velocity preceded that of blood volume and was associated more deeply with the reduction of blood flow.In conclusion, cutaneous microcirculatory monitoring using laser Doppler flowmetry is a sensitive technique for detecting early changes of circulatory failure caused by hemorrhage.
Evaluation of rate‐pressure product in obese children
Authors: HO TING FEI , YIP WILLIAM CHIN LING 
Published: January 2011

AbstractThe purpose of this study was to evaluate the relationship between rate‐pressure product (RPP) and degree of obesity in 511 obese 7 and 12 year old Chinese children. Obesity was assessed by anthropometry and skinfold thickness. The children were defined obese by relative weight (RW) > 120%. Bodyweight (W) and height (H) were used to derive body mass index (W/H2). Brachial systolic and diastolic pressures in these children were measured by cuff sphygmomanometry. RPP was calculated by the formula: heart rate x mean arterial pressure.More obese children (RW ≥ 150%) had greater mean RPP (7 year old: 6389 vs 5976 beats/min x mmHg, P < 0.05; 12 year old: 7024 vs 6686 beats/min x mmHg) than those with RW < 150%. Children in the upper 25 percentiles of RPP had significantly larger BMI (7 and 12 year olds) and RW (12 year olds), thicker biceps, triceps and subscapular skinfolds (12 year olds) (P < 0.01 ‐ < 0.05).The results indicate that RPP is, to some extent, related to the degree of obesity in obese children. The differences in RPP may imply varying degrees of hemodynamic stress to the heart. Whether such differences may contribute to the long‐term development of cardiovascular morbidity in more obese individuals is uncertain.