bluuebunny/crossref_metadata_2025_split huggingface dataset:
Which Drugs are More Effective in Preventing Familial Adenomatous Polyposis
Progression based on Network Meta-analysis?
Authors: Luo Pei , Shi Wenjun , Cheng Xianshuo , Yang Jun , Pei Gen , Dong Jian 
Published: May 2024

Background:
Familial adenomatous polyposis (FAP) is an inherited disorder. At present, an increasing
number of medications are being employed to treat FAP; however, only a few have been assessed for
their efficacy and safety. Therefore, this study aimed to conduct a network meta-analysis to compare the therapeutic
outcomes and adverse drug reactions of all FAP-associated medications.

Methods:
Six relevant databases were searched to identify pertinent randomized controlled trials (RCTs), and
information on the dosage and frequency of various drugs was extracted. Additionally, data on changes in
polyp counts and dimensions, as well as treatment-related adverse reactions for different medications were
collected. The Bayesian method was employed to directly or indirectly compare the impact of different treatment
regimens on changes in polyp numbers and diameters, and the safety of the drugs was investigated.

Results:
CXB at 16 mg/kg/day significantly reduced polyp numbers. Celecoxib at 8 mg/kg/day and sulindac
(150 mg twice daily) plus erlotinib (75 mg/day) were effective for tolerant FAP patients. Additionally, EPAFFA
2 g daily and sulindac (150 mg twice daily) plus erlotinib (75 mg/day) emerged as the most effective for
reducing polyp size.

Conclusion:
The most effective treatment for reducing the number of colorectal polyps is celecoxib 16
mg/kg/day. On the other hand, a daily dosage of 2 g EPA-FFA demonstrates the best results in terms of decreasing
colorectal polyp diameter.
Deciphering the Pharmacological Mechanisms of Wen-Jing-Zhi-Tong
Decoction in Treating Primary Dysmenorrhea by UPLC-Q-ExactiveOrbitrap-MS/MS with GC-MS and Network Pharmacology
Authors: Yang Xiaotian , Qin Yajie , Zhou Huifang 
Published: May 2024

Background:
Primary dysmenorrhea (PDM) is a prevalent menstrual disorder among
women, often underreported and undertreated. Wen-Jing-Zhi-Tong Decoction (WJZTD), a patented Traditional Chinese Medicine (TCM) herbal decoction, has shown efficacy in treating
PDM. However, the underlying therapeutic mechanism of WJZTD in PDM treatment remains to
be elucidated.

Objective:
This study aimed to employ integrative pharmacology and experimental validation to
investigate the potential therapeutic mechanisms of WJZTD in treating PDM.

Methods:
The bioactive compounds of WJZTD were identified by UPLC-Q-Exactive-Orbitrap
MS/MS and GC-MS. Putative targets of WJZTD were obtained from Swiss Target Prediction,
STITCH, and BATMAN-TCM databases. Known targets of PDM were retrieved from Gene
Cards and Drug Bank databases. Protein-to-protein interactions were constructed to screen key
targets using the STRING database. Subsequently, GO and KEGG pathway enrichment analyses
were performed based on Metascape. Finally, a PDM rat model was established to validate the
potential therapeutic mechanisms of WJZTD using Western Blot, PCR, and ELISA.

Conclusion:
This study provides the first comprehensive analysis of the key compounds, targets,
and pathways of WJZTD, laying a solid foundation for future pharmacological studies on PDM.
The anti-nociceptive and anti-inflammatory effect may be attributed to the downregulation of the
BDNF/TrkB/ERK/CREB signaling pathway.
Different Disinfection Protocols for Pulp Revitalization: An In Vitro Study
Authors: Barroso Leonardo dos Santos , Baroudi Kusai , Nunes Adriana Marques , de Paula Milena Nascimento , da Silva Concílio Laís Regiane , Habitante Sandra Márcia 
Published: May 2024

Objectives
Pulp revitalization is a procedure indicated for immature teeth with pulp necrosis. This study aimed to investigate the microbial load reduction of four cleaning protocols for pulp revitalization: Prophylactic Brush for canal (MK Life), microbrush Aplik Extrafine (Angelus), n. 50 K file (Dentsply) and XP Endo Finisher (FKG).

Materials and Methods
Fifty single-rooted mandibular premolars were standardized in canal size and diameter. Contamination by E. faecalis was induced for 21 days in 50 specimens, where 48 were used for the experimental groups (n=12) and 2 were used as a negative control to validate the sterilization process before contamination. Irrigation with saline solution at 36.5°C was performed, where the mechanical resource for cleaning was varied (n=12). Colony counting (CFU) was performed before (S1) and after (S2) the cleaning procedure. Kruskal Wallis accounted for and analyzed the differences between S2 and S1.

Results & Discussion
Prophylactic Brush for the canal reduced 99.27% of the microbial load, followed by XP Endo Finisher (99.13%), Aplik microbrush (98.71%) and K file (98.66%). (p=0.3616). There was no statistical difference in the reduction of microbial load between the groups tested.

Conclusion
The mechanical cleaning methods tested alone were effective in substantially reducing the microbial load of E. faecalis on lower premolars by simulating open apex teeth and showed that bristle instruments such as Prophylactic Brush for Canal and microbrush Aplik Extrafine could be used to accomplish mechanical debridement of large canals.
Distribution Map Analysis of Independent Living Skills through Rasch Model in Primary School Students
Authors: Mulyasari Effy , Ali Mohammad , Sukirman Dadang , Hamzah Rifqy Muhammad 
Published: May 2024

Independent living skills need to be mastered by every student both in dealing with everyday life and in the school environment in the 21st century. Students must be able to develop their life skills so they can be independent and develop optimally. This study aims to analyze the grouping of the level of choice of Independent Living Skills items in elementary schools based on the teacher's perception of students through a combination of the standard deviation value (SD) and the logit average value (Mean). The research was conducted on elementary school teachers in West Java. The analysis was carried out through the Rasch Model with the Winstep application. The results of this analysis can indicate that there are various levels of choice of Independent Living Skills items. The grouping is based on hard-to-select items with a logit value greater than +1SD; difficult categories with a logit value of 0.0 logit +1SD; easy-to-select categories 0.0 logit – 1SD; and it is very easy to select with a value smaller than -SD. From this study it can be concluded that the Independent Life Skills instrument items can identify various levels of student independence. This instrument can be used for initial semester assessments in “Kurikulum Merdeka”.
The Integration of the Nature of Science and Religion to Increase Students’ Religious Beliefs in Acquiring Scientific Knowledge at the Elementary School
Authors: Tursinawati Tursinawati , Fitriani Suci , Safiah Intan , Widodo Ari , Sopandi Wahyu , Amiruddin M. Hasbi 
Published: May 2024

Various efforts have been made to increase students' understanding and scientific skills in science learning; however, religion is often ignored. This study seeks to integrate science and religion concepts in increasing students' religious beliefs to acquire scientific knowledge. This study used mixed methods research. The samples, consisting of 100 students and four teachers from four elementary schools in Aceh province, were chosen randomly. Data were collected from student questionnaires, teacher interviews, and observation of learning implementation. The research results found that there has been no integration of the concepts of science and religion by linking NOS (Nature of Science) aspects and religious beliefs in acquiring scientific knowledge in science learning in elementary schools. The integration carried out previously was by integrating the verses of the Qur'an into scientific concepts. The implementation of integrating the concepts of science and religion increased religious beliefs in acquiring scientific knowledge among elementary school students. Most students strongly agree with religious beliefs in acquiring knowledge. Students strongly agree that science is a way to get closer to God. In learning science, teachers should integrate NOS and religious beliefs in acquiring scientific knowledge through impressions of feelings, reasoning, and intuition toward God's creation. This research should contribute to the understanding of science and NOS concepts related to the topics of science and religion, how scientists work, social culture, moral values, and emotional and spiritual intelligence.
Analysis of Speaking Skills in Speech of Grade VI Students: A Case Study of Pedurungan Kidul 02 Semarang Elementary School
Authors: Causarina Princesa Vitara , Ahmadi Farid 
Published: May 2024

Everyone can make a speech, but not everyone can make a good and correct speech. Everyone needs to develop speaking skills in everyday life. Therefore, this research aims to describe the speaking skills of class VI students: a case study of SD Pedurungan Kidul 02 Semarang.This research was conducted at SD Negeri Pedurungan Kidul 02, Semarang City, Central Java. The data collected are qualitative in the form of narratives regarding the ability of speaking skills in delivering speeches, factors that influence speaking skills, and efforts to improve speaking skills in delivering opinions. The data sources used were primary data and secondary data. The data collection techniques used were observation, interview, test, and documentation. The results of this research are that the speaking skills of the three class VI students at SD Negeri Pedurungan Kidul 02 Semarang City are categorized as "low". This is shown based on the results of the three students. There are several indicators that are still not understood by students, namely indicators of pronunciation, fluency, and body gestures. Factors that can affect students' speaking skills are divided into supporting factors and inhibiting factors. Supporting factors include methods, models, learning media, student memorization, word selection, and pausing on punctuation. While the inhibiting factors are the existence of a person's pronunciation tool that is less than perfect and the lack of learning assistance to children.
Evaluating the Problem of Fraudulent Participants in Health Care Research: Multimethod Pilot Study
Authors: Kumarasamy Vithusa , Goodfellow Nicole , Ferron Era Mae , Wright Amy L 
Published: May 2024

Background
The shift toward online recruitment methods, accelerated by the COVID-19 pandemic, has brought to the forefront the growing concern of encountering fraudulent participants in health care research. The increasing prevalence of this issue poses a serious threat to the reliability and integrity of research data and subsequent findings.

Objective
This study aims to explore the experiences of health care researchers (HCRs) who have encountered fraudulent participants while using online recruitment methods and platforms. The primary objective was to gain insights into how researchers detect and mitigate fraudulent behavior in their work and provide prevention recommendations.

Methods
A multimethod sequential design was used for this pilot study, comprising a quantitative arm involving a web-based survey followed by a qualitative arm featuring semistructured interviews. The qualitative description approach framed the qualitative arm of the study. Sample sizes for the quantitative and qualitative arms were based on pragmatic considerations that in part stemmed from encountering fraudulent participants in a concurrent study. Content analysis was used to analyze open-ended survey questions and interview data.

Results
A total of 37 HCRs participated, with 35% (13/37) of them engaging in qualitative interviews. Online platforms such as Facebook, email, Twitter (subsequently rebranded X), and newsletters were the most used methods for recruitment. A total of 84% (31/37) of participants indicated that fraudulent participation occurred in studies that mentioned incentives in their recruitment communications, with 71% (26/37) of HCRs offering physical or electronic gift cards as incentives. Researchers identified several indicators of suspicious behavior, including email surges, discrepancies in contact or personal information, geographical inconsistencies, and suspicious responses to survey questions. HCRs emphasized the need for a comprehensive screening protocol that extends beyond eligibility checks and is seamlessly integrated into the study protocol, grant applications, and research ethics board submissions.

Conclusions
This study sheds light on the intricate and pervasive problem of fraudulent participation in health care research using online recruitment methods. The findings underscore the importance of vigilance and proactivity among HCRs in identifying, preventing, and addressing fraudulent behavior. To effectively tackle this challenge, researchers are encouraged to develop a comprehensive prevention strategy and establish a community of practice, facilitating real-time access to solutions and support and the promotion of ethical research practices. This collaborative approach will enable researchers to effectively address the issue of fraudulent participation, ensuring the conduct of high-quality and ethically sound research in the digital age.
Recovery and Renewal of Co-Design Approaches in Health: Protocol for a Realist Synthesis
Authors: Mallakin Maryam , Langley Joe , Harvey Gillian , Walker Sarah , Raber Caylee , Beyzaei Nadia , Paczka Giorgi Luz A , Holyoke Paul , Sellen Kate 
Published: May 2024

Background
The COVID-19 pandemic significantly transformed the landscape of work and collaboration, impacting design research methodologies and techniques. Co-design approaches have been both negatively and positively affected by the pandemic, prompting a need to investigate and understand the extent of these impacts, changes, and adaptations, specifically in the health sector. Despite the challenges that the pandemic imposed on conducting co-design and related projects, it also encouraged a re-evaluation of co-design practices, leading to innovative solutions and techniques. Designers and researchers have explored alternative ways to engage stakeholders and end users, leveraging digital workshops and participatory digital platforms. These adaptations have the potential to enhance inclusivity, allowing for a wider range of individuals to contribute their perspectives and insights through co-design and thus contribute to healthcare change.

Objective
This study aims to explore the impacts of the pandemic on co-design and related practices, focusing on co-design practices in healthcare that have been gained, adapted, or enhanced, with a specific focus on issues of equity, diversity, and inclusion.

Methods
The study uses a realist synthesis methodology to identify and analyze the effects of the pandemic on co-design approaches in health, drawing on a range of sources including first-person experiences, gray literature, and academic literature. A community of practice in co-design in health will be engaged to support this process.

Results
By examining the experiences and insights of professionals, practitioners, and communities who were actively involved in co-design and have navigated the challenges and opportunities of the pandemic, we can gain a deeper understanding of the strategies, tools, and techniques that have facilitated effective co-design during the pandemic, contributing to building resilience and capacity in co-design in health beyond the pandemic.

Conclusions
By involving community partners, community of practice (research), and design practitioners, we expect closer proximity to practice with capacity building occurring through the realist process, thus enabling rapid adoption and refinement of new techniques or insights that emerge. Ultimately, this research will contribute to the advancement of co-design methodologies and inform the future of co-design in health.

International Registered Report Identifier (IRRID)
DERR1-10.2196/58318
Quality Improvement of Kesambi-Seed Oil using Free Fatty Acids and Hydrogen Cyanide Adsorption
Authors: Setyawardhani Dwi Ardiana , Umpati Diah Sri , Fahroni Yudi Eka 
Published: May 2024

Kesambi-seed (Schleichera oleosa) is an Indonesian potential feedstock to produce vegetable oil for energy resources and oleochemicals. Crude Kesambi-seed oil (KSO) contains 8.43% free fatty acids (FFA) and 128 ppm hydrogen cyanide (HCN), which exceeds the Indonesian National Standard (SNI) for refined oil. Purification process is needed for crude KSO to be high quality vegetable oil. This study aimed to improve the quality of KSO by reducing the FFA and HCN contents using adsorption. The adsorption equilibrium is also determined to obtain the equilibrium constants. The purification process was developed in 2 steps, i.e., degumming and adsorption. Degumming was developed using 2.5% v/v H3PO4 to separate phospholipids/phosphatides in the crude oil, while adsorption using activated carbon was introduced to reduce the FFA and HCN contents. Kesambi-seed oil purification using activated carbon adsorption could be used as one-step refining for bleaching and reducing FFA and HCN. More adsorbent is needed to reach the FFA standard for the shorter adsorption time. Adsorption using 10% activated carbon for 24 hours reduced hydrogen cyanide up to 36 mg/kg oil, lightened the oil color, and achieved the highest yield (74.62%). Meanwhile, the activated carbon concentration of 40% w/w for 96 hours obtained 0.16% FFA. All three parameters have fulfilled the Indonesian National Standard for refined vegetable oil. Furthermore, the Freundlich model best fits equilibrium adsorption of FFA in the KSO.
Enhanced Copper Ion Adsorption by Rice Husk and Sugarcane Bagasse-based Magnetic Nanoparticles Biocomposites
Authors: Nata Iryanti , Irawan Chairul , Hudha Muhammad Istnaeny , Lesti Aceng , Syarkani Muhammad Hersandy , Naufal Allam 
Published: May 2024

Rice husk and sugarcane bagasse are biomass waste by-products of agriculture activities. High cellulose content makes them a potential material to develop. Biomass utilization is more interesting to develop due to its high cellulose content and nature abundance. Cellulose from rice husk and sugarcane bagasse is utilized as fiber in producing magnetic biocomposites. The Biocomposites can adsorb Cu(II) ions in aqueous solutions. A one-step solvothermal reaction was used to synthesize biocomposites. The amine functionalization on biocomposites was also studied for adsorption performance. The magnetic particle was generated on the surface of fiber and verified by XRD as Fe3O4. Amine group on biocomposites is also found on 570 cm-1 and 1636 cm−1 peaks for Fe-O bonds and N-H bending, respectively. Batch isothermal adsorption employing magnetic biocomposites has optimal conditions for Cu(II) ions adsorption at pH 5 for 60 minutes, with an adsorption capacity of 118.26 mg/g. The reusability of biocomposites for the next run showed a good performance at 3rd repetitions with only a decrease in adsorption capacity of 8.81%. The rice husk and sugarcane bagasse-based magnetic nanoparticles biocomposites can adsorb Cu(II) ions and potential material to develop for wastewater treatment.
Social Media as Heterotopia: Exploring the Dynamics of Cancel Culture in the Gisella Anastasia Sex Video Scandal
Authors: Wulandari Nur Laily , Habsari Sri Kusumo , Susanto Susanto 
Published: May 2024

This study examines the phenomenon of cancel culture on social media, focusing on the controversy surrounding the case of Gisella Anastasia's nude video. Utilizing Michel Foucault's heterotopia theory, this research investigates how social media platforms like Instagram serve as heterotopias that shape new norms and challenge social rules. The study analyzes Instagram's role in cancel culture, exemplified by the Gisella Anastasia case, and netizen responses. It explores how digital spaces blur the distinction between reality and virtuality, impacting individual freedom and identity formation. Through text and content analysis, this research uncovers power dynamics within Gisella Anastasia's Instagram accounts, @hopsindonesia, and @Rananews.id, over specific time frames. The findings indicate that social media functions as a heterotopic space where netizens contest societal norms and challenge the hegemony of identities in society. Anonymity encourages damaging comments and perpetuates cancel culture, acting as resistance against societal norms and identities. The absence of hierarchy in social media fosters boundaryless behavior among netizens, sometimes leading to excessive brutality.Keywords: cancel culture, spatiality, power, social media.
Preptin as a Potential Marker in Iraqi Newly Diagnosed T2DM and T2DM with cardiovascular disease.
Authors: Tahir Noor Thair , Al-Khateeb Shatha M. J. , Shams Akram Raghda 
Published: May 2024

Objective: The aim of present work is to study the Role of preptin level in Iraqi type 2 diabetes patients and related with other biochemical parameters.
Methods: This study was including (88) partespents, (22) newly diagnosed T2DM, (22) T2DM and (22) ischemic heart disease with T2DM, and (22) as healthy control, age ranged (35-63) years.
Results: The findings indicate that individuals with type 2 diabetes mellitus (T2DM) exhibited markedly elevated levels of FBS, HbA1C, insulin, HOMA-IR, TC, TG, LDL-C, VLDL-C, and preptin in comparison to the control group. These differences were statistically significant (p<0.0001). Moreover, the Pearson correlation analysis revealed that preptin levels were positively associated with FBS, HbA1c, TC, TG, LDL, VLDL, insulin, and HOMA-IR while exhibiting a negative correlation with HDL.
Conclusion: Because preptin plays a critical function in controlling sugar metabolism and, consequently, sugar problems, excessive levels of preptin play a significant role in the patient's inability to control both their level of glycosylated hemoglobin and their blood sugar levels. preptin levels are therefore high in diabetics and those with heart disease, which results in a loss of control over the body's metabolism and exposes a patient to many other ailments.
Prothrombin G20210A mutation in Sudanese women with recurrent pregnancy loss
Authors: Awad Elkareem  , Alzaki Salaheldein G. , Mohammed Mubark A. , Ibrahim Abdalrahman A. , Eltayeb Amel N. , Abdellatief Alaa K. , Mustafa Anna A. , Elsayed Matab A. , Osman Esraa H. , Haj Taha Enas Y. 
Published: May 2024

The association between the Prothrombin G20210A mutation and recurrent pregnancy loss is well documented in the literature among different populations. A descriptive study was conducted in Omdurman Maternity Hospital, Sudan, to find the prevalence of the Prothrombin G20210A mutation among Sudanese women with recurrent pregnancy loss. Analysis of the Prothrombin G20210A mutation was performed using PCR-RFLP for 67 enrolled women with recurrent pregnancy loss of two times or more. Data analysis was performed using SPSS. The prothrombin G20210A mutation was present in 4 (6%) out of the total 67 enrolled cases; 3 (4.5%) had the GA genotype (hetrozygous), while one had the (1.5%) AA genotype. The study revealed that the Prothrombin G20210A mutation is less prevalent among Sudanese women with recurrent pregnancy loss compared to other Arab nations. A large case-control study is needed.