bluuebunny/crossref_metadata_2025_split huggingface dataset:
Report of the 2011 annual meeting of the italian society for virology
Authors: Salata Cristiano , Calistri Arianna , Parolin Cristina , Palù Giorgio 
Published: January 2012

AbstractThe 10th annual meeting of the Italian Society for Virology (SIV) comprised seven plenary sessions focused on: General virology and viral genetics; Virus–Host interaction and pathogenesis; Viral oncology; Emerging viruses and zoonotic, foodborne and environmental pathways of transmission; Viral immunology and vaccines; Medical virology and antiviral therapy; Viral biotechnologies and gene therapy. The meeting had an attendance of 143 virologists, about 60% were senior, and the other were young scientists. The submitted abstracts amounted to 88 and the abstracts selected for oral presentation were 41. Complete abstracts of oral and poster presentations are available at the web site www.siv‐virologia.it. A summary of the plenary lectures and oral selected presentations is reported. J. Cell. Physiol. 227: 2965–2968, 2012. © 2012 Wiley Periodicals, Inc.
Bone marrow stromal cells stimulate an angiogenic program that requires endothelial MT1‐MMP
Authors: Kachgal Suraj , Carrion Bita , Janson Isaac A. , Putnam Andrew J. 
Published: January 2012

AbstractBone marrow‐derived stromal/stem cells (BMSCs) have recently been characterized as mediators of tissue regeneration after injury. In addition to preventing fibrosis at the wound site, BMSCs elicit an angiogenic response within the fibrin matrix. The mechanistic interactions between BMSCs and invading endothelial cells (ECs) during this process are not fully understood. Using a three‐dimensional, fibrin‐based angiogenesis model, we sought to investigate the proteolytic mechanisms by which BMSCs promote vessel morphogenesis. We find that BMSC‐mediated vessel formation depends on the proteolytic ability of membrane type 1‐matrix metalloproteinase (MT1‐MMP). Knockdown of the protease results in a small network of vessels with enlarged lumens. Contrastingly, vessel morphogenesis is unaffected by the knockdown of MMP‐2 and MMP‐9. Furthermore, we find that BMSC‐mediated vessel morphogenesis in vivo follows mechanisms similar to what we observe in vitro. Subcutaneous, cellular fibrin implants in C.B‐17/SCID mice form aberrant vasculature when MMPs are inhibited with a broad‐spectrum chemical inhibitor, and a very minimal amount of vessels when MT1‐MMP proteolytic activity is interrupted in ECs. Other studies have debated the necessity of MT1‐MMP in the context of vessel invasion in fibrin, but this study clearly demonstrates its requirement in BMSC‐mediated angiogenesis. J. Cell. Physiol. 227: 3546–3555, 2012. © 2012 Wiley Periodicals, Inc.
Non‐saturation of the non‐stationary ideal onPκ(λ) with λ of countable cofinality
Authors: Matet Pierre 
Published: January 2012

AbstractGiven a regular uncountable cardinal κ and a cardinal λ > κ of cofinality ω, we show that the restriction of the non‐stationary ideal onPκ(λ) to the set of allawith\documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}$\mathrm{cf}(\sup (a\cap \kappa)) = \omega$\end{document}is not λ++‐saturated (and even not\documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}$2^{{(\lambda ^{<\kappa }})}$\end{document}‐saturated in case 2λ= λ+). We actually prove the stronger result that there is\documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}$Q\subseteq \mathrm{NG}_{\kappa ,\lambda }^+$\end{document}with |Q| = λ++such thatA∩Bis a non‐cofinal subset ofPκ(λ) for any two distinct membersA,BofQ, where NGκ, λdenotes the game ideal onPκ(λ). We also remark that for κ > ω1, adding λ+3Cohen subsets of ω1to\documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}$\mathbf {L}$\end{document}makes NGκ, λλ+3‐saturated.
Water‐Developable Poly(2‐oxazoline)‐Based Negative Photoresists
Authors: Schenk Verena , Ellmaier Lisa , Rossegger Elisabeth , Edler Matthias , Griesser Thomas , Weidinger Gerald , Wiesbrock Frank 
Published: January 2012

AbstractCopoly(2‐oxazoline)‐based photoresists are prepared from pEtOx80Bu=Ox20 and pPhOx80Dc=Ox20, respectively, a tetrathiol, and a photosensitive initiator. It is possible to prepare copoly(2‐oxazoline)s bearing unsaturated side chains in a microwave reactor on a decagram scale in reaction times of 100 min or shorter. UV irradiation of dried polymer films through a quartz mask induces the thiol‐ene reaction in the illuminated areas. Subsequent development of the polymer films in halogen‐free solvents reproduces the negative pattern of the mask with a resolution of 2 μm. The pEtOx80Bu=Ox20‐derived photoresists can also be developed in water.
Immobilized contrast‐enhanced MRI: Gadolinium‐based long‐term MR contrast enhancement of the vein graft vessel wall
Authors: Mitsouras Dimitris , Vemula Praveen Kumar , Yu Peng , Tao Ming , Nguyen Binh T. , Campagna Christina M. , Karp Jeffrey M. , Mulkern Robert V. , Ozaki C. Keith , Rybicki Frank J. 
Published: January 2012

AbstractAn implantable MR contrast agent that can be covalently immobilized on tissue during surgery has been developed. The rationale is that a durable increase in tissue contrast using an implantable contrast agent can enhance postsurgical tissue differentiation using MRI. For small‐vessel (e.g., vein graft) MRI, the direct benefit of such permanent “labeling” of the vessel wall by modification of its relaxation properties is to achieve more efficient imaging. This efficiency can be realized as either increased contrast leading to more accurate delineation of vessel wall and lesion tissue boundaries, or, faster imaging without penalizing contrast‐to‐noise ratio, or a combination thereof. We demonstrate, for the first time, stable long‐term MRI enhancement using such an exogenous contrast mechanism based on immobilizing a modified diethylenetriaminepentaacetic acid gadolinium3+ dihydrogen complex on a human vein using a covalent amide bond. Signal enhancement due to the covalently immobilized contrast agent is demonstrated for excised human vein specimens imaged at 3 T, and its long‐term stability is demonstrated during a 4‐month incubation period. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.
Living Well with Rheumatoid Arthritis
Authors: Squire Ruth 
Published: January 2012

AbstractPurposeThe overall aim of this study was to understand the occupational lives of people with rheumatoid arthritis. Further aims were to identify the creative agency that occurs while performing these occupations and to understand the socio‐cultural aspects of engaging in valued occupations.MethodsFive participants were recruited and various qualitative methods of data collection were engaged, including open interviews, participant observation and gathering occupational diaries. A combination of thematic and narrative analysis was performed.ResultsFindings uncovered six themes, including; changing occupations; environmental factors count; taking control over occupations; being or becoming normal; people and objects are important; hopes and dreams matter. Subthemes uncovered how individuals constantly adapt and alter their occupations; some radically changing lifestyles for the better, while others work towards regaining occupational control. Meaning of occupations became apparent. People were creative agents. Work and leisure occupations featured strongly. Objects and other individuals were significant factors to individuals when engaging in occupations. People strived to be ‘normal’ in their occupational worlds.ConclusionThe implication of these results in relation to professional practice for therapists is that attention should be refocused on the occupational narratives of clients, working with the positive, creative aspects that people are already employing and building on these in areas that might not been seen as traditional, such as work and leisure. Copyright © 2012 John Wiley & Sons, Ltd.
A systematic review of validated methods for identifying cerebrovascular accident or transient ischemic attack using administrative data
Authors: Andrade Susan E. , Harrold Leslie R. , Tjia Jennifer , Cutrona Sarah L. , Saczynski Jane S. , Dodd Katherine S. , Goldberg Robert J. , Gurwitz Jerry H. 
Published: January 2012

ABSTRACTPurposeTo perform a systematic review of the validity of algorithms for identifying cerebrovascular accidents (CVAs) or transient ischemic attacks (TIAs) using administrative and claims data.MethodsPubMed and Iowa Drug Information Service searches of the English language literature were performed to identify studies published between 1990 and 2010 that evaluated the validity of algorithms for identifying CVAs (ischemic and hemorrhagic strokes, intracranial hemorrhage, and subarachnoid hemorrhage) and/or TIAs in administrative data. Two study investigators independently reviewed the abstracts and articles to determine relevant studies according to pre‐specified criteria.ResultsA total of 35 articles met the criteria for evaluation. Of these, 26 articles provided data to evaluate the validity of stroke, seven reported the validity of TIA, five reported the validity of intracranial bleeds (intracerebral hemorrhage and subarachnoid hemorrhage), and 10 studies reported the validity of algorithms to identify the composite endpoints of stroke/TIA or cerebrovascular disease. Positive predictive values (PPVs) varied depending on the specific outcomes and algorithms evaluated. Specific algorithms to evaluate the presence of stroke and intracranial bleeds were found to have high PPVs (80% or greater). Algorithms to evaluate TIAs in adult populations were generally found to have PPVs of 70% or greater.ConclusionsThe algorithms and definitions to identify CVAs and TIAs using administrative and claims data differ greatly in the published literature. The choice of the algorithm employed should be determined by the stroke subtype of interest. Copyright © 2012 John Wiley & Sons, Ltd.
Design considerations in an active medical product safety monitoring system
Authors: Gagne Joshua J. , Fireman Bruce , Ryan Patrick B. , Maclure Malcolm , Gerhard Tobias , Toh Sengwee , Rassen Jeremy A. , Nelson Jennifer C. , Schneeweiss Sebastian 
Published: January 2012

ABSTRACTActive medical product monitoring systems, such as the Sentinel System, will utilize electronic healthcare data captured during routine health care. Safety signals that arise from these data may be spurious because of chance or bias, particularly confounding bias, given the observational nature of the data. Applying appropriate monitoring designs can filter out many false‐positive and false‐negative associations from the outset. Designs can be classified by whether they produce estimates based on between‐person or within‐person comparisons. In deciding which approach is more suitable for a given monitoring scenario, stakeholders must consider the characteristics of the monitored product, characteristics of the health outcome of interest (HOI), and characteristics of the potential link between these. Specifically, three factors drive design decisions: (i) strength of within‐person and between‐person confounding; (ii) whether circumstances exist that may predispose to misclassification of exposure or misclassification of the timing of the HOI; and (iii) whether the exposure of interest is predominantly transient or sustained. Additional design considerations include whether to focus on new users, the availability of appropriate active comparators, the presence of an exposure time trend, and the measure of association of interest. When the key assumptions of self‐controlled designs are fulfilled (i.e., lack of within‐person, time‐varying confounding; abrupt HOI onset; and transient exposure), within‐person comparisons are preferred because they inherently avoid confounding by fixed factors. The cohort approach generally is preferred in other situations and particularly when timing of exposure or outcome is uncertain because cohort approaches are less vulnerable to biases resulting from misclassification. Copyright © 2012 John Wiley & Sons, Ltd.
The Food and Drug Administration's Post‐Licensure Rapid Immunization Safety Monitoring program: strengthening the federal vaccine safety enterprise
Authors: Nguyen Michael , Ball Robert , Midthun Karen , Lieu Tracy A. 
Published: January 2012

ABSTRACTIn 2009, the Department of Health and Human Services created the new Post‐Licensure Rapid Immunization Safety Monitoring (PRISM) program, which used data from national health insurance plans and immunization registries to monitor the safety of the H1N1 influenza vaccine. PRISM has now been integrated into the FDA's Mini‐Sentinel pilot program. It strengthens the federal vaccine safety enterprise in two important ways. First, PRISM monitors the largest US general population cohort designated for active surveillance of vaccine safety. Second, PRISM links data from health plans with data from state and city immunization registries, which were a crucial source of exposure data in the H1N1 vaccine evaluation. The Mini‐Sentinel data that support PRISM are updated quarterly, and PRISM can conduct medical record review for validation of computerized data.The FDA has structured PRISM as a program that includes specific vaccine evaluations, development of an operational framework to guide the design of vaccine safety evaluations, and development of new statistical methods. A human papillomavirus vaccine, Gardasil, and two rotavirus vaccines, RotaTeq and Rotarix, have been chosen for surveillance in the current cycle because their evaluations would benefit most from PRISM's large cohort size.The PRISM program creates important opportunities by offering a robust, responsive new surveillance program with features complementary to existing systems. Methodological and logistical lessons can be shared among PRISM and other surveillance systems, offering potential synergies. FDA and PRISM will work to maximize the program's unique strengths and contributions to a unified federal vaccine safety enterprise. Copyright © 2012 John Wiley & Sons, Ltd.
Challenges in the design and analysis of sequentially monitored postmarket safety surveillance evaluations using electronic observational health care data
Authors: Nelson Jennifer C. , Cook Andrea J. , Yu Onchee , Dominguez Clara , Zhao Shanshan , Greene Sharon K. , Fireman Bruce H. , Jacobsen Steven J. , Weintraub Eric S. , Jackson Lisa A. 
Published: January 2012

ABSTRACTPurposeMany challenges arise when conducting a sequentially monitored medical product safety surveillance evaluation using observational electronic data captured during routine care. We review existing sequential approaches for potential use in this setting, including a continuous sequential testing method that has been utilized within the Vaccine Safety Datalink (VSD) and group sequential methods, which are used widely in randomized clinical trials.MethodsUsing both simulated data and preliminary data from an ongoing VSD evaluation, we discuss key sequential design considerations, including sample size and duration of surveillance, shape of the signaling threshold, and frequency of interim testing.Results and ConclusionsAll designs control the overall Type 1 error rate across all tests performed, but each yields different tradeoffs between the probability and timing of true and false positive signals. Designs tailored to monitor efficacy outcomes in clinical trials have been well studied, but less consideration has been given to optimizing design choices for observational safety settings, where the hypotheses, population, prevalence and severity of the outcomes, implications of signaling, and costs of false positive and negative findings are very different. Analytic challenges include confounding, missing and partially accrued data, high misclassification rates for outcomes presumptively defined using diagnostic codes, and unpredictable changes in dynamically accessed data over time (e.g., differential product uptake). Many of these factors influence the variability of the adverse events under evaluation and, in turn, the probability of committing a Type 1 error. Thus, to ensure proper Type 1 error control, planned sequential thresholds should be adjusted over time to account for these issues. Copyright © 2012 John Wiley & Sons, Ltd.
A systematic review of validated methods for identifying suicide or suicidal ideation using administrative or claims data
Authors: Walkup James T. , Townsend Lisa , Crystal Stephen , Olfson Mark 
Published: January 2012

ABSTRACTPurposeAs part of the Mini‐Sentinel pilot program, under contract with the Food and Drug Administration, an effort has been made to evaluate the validity of algorithms useful for identifying health outcomes of interest, including suicide and suicide attempt.MethodLiterature was reviewed to evaluate how well medical episodes associated with these events could be identified in administrative or claims data sets from the USA or Canada.ResultsSix studies were found to include sufficient detail to assess performance characteristics of an algorithm on the basis of International Classification of Diseases, Ninth Revision, E‐codes (950–959) for intentional self‐injury. Medical records and death registry information were used to validate classification. Sensitivity ranged from 13.8% to 65%, and positive predictive value range from 4.0% to 100%. Study comparisons are difficult to interpret, however, as the studies differed substantially in many important elements, including design, sample, setting, and methods. Although algorithm performance varied widely, two studies located in prepaid medical plans reported that comparisons of database codes to medical charts could achieve good agreement.ConclusionsInsufficient data exist to support specific recommendations regarding a preferred algorithm, and caution should be exercised in interpreting clinical and pharmacological epidemiological surveillance and research that rely on these codes as measures of suicide‐related outcomes. Copyright © 2012 John Wiley & Sons, Ltd.
A systematic review of validated methods for identifying ventricular arrhythmias using administrative and claims data
Authors: Tamariz Leonardo , Harkins Thomas , Nair Vinit 
Published: January 2012

ABSTRACTBackgroundDrug‐induced pro‐arrhythmia is a serious and unexpected event. Large administrative and claims databases can potentially identify drugs or interactions leading to cardiac arrhythmias. The purpose of this study is to evaluate the evidence supporting the validity of algorithms or codes to identify ventricular arrhythmias using administrative and claims data.MethodsA search of MEDLINE database is supplemented by manual searches of bibliographies of key relevant articles. We selected all studies in which an administrative and claims data algorithm or code was validated against a medical record. We report the positive predictive value (PPV) for ICD‐9 codes compared to medical records.ResultsOur search strategy yielded 664 studies, of which only seven met our eligibility criteria. Two additional studies were identified by peer reviewers. The most commonly included databases were Medicare and Medicaid, and the most commonly evaluated ICD‐9 codes were 426.x and 427.x. The individual use of ICD‐9 codes 427.x yielded a high PPV (78%–100%). The highest PPV was seen when both ICD‐9 codes 427.x and 798.x were used (92%). The same codes yielded the highest PPV when found in the principal diagnosis position (100%).ConclusionsThe use of ICD‐9 codes 427.x, alone or in combination with code 798.x, in the principal position is appropriate for the identification of ventricular arrhythmias in administrative and claims databases. Copyright © 2012 John Wiley & Sons, Ltd.
Amino‐rich Plasma Polymer Films Prepared by RF Magnetron Sputtering
Authors: Hanuš Jan , Ceccone Giacomo , Rossi François 
Published: January 2012

AbstractRadio frequency magnetron sputtering of nylon 6.6 followed by N2/H2 plasma post‐treatment was used for deposition of nitrogen‐rich film with amino functionalities on the surface. The maximal NH2/C concentration obtained was 11% and the NH2/N reached 13.5%. The films are positively charged with an isoelectric point of 4.5. The interaction between the film and the buffer solution was studied and shows that the films are stable in cell culture conditions. A quartz crystal microbalance study showed the ability of the films to adsorb different proteins and their antigens and quantifies the protein adsorbed as a function of the films properties.magnified image
Effects of Additives on ε‐HNIW Crystal Morphology and Impact Sensitivity
Authors: Chen Huaxiong , Li Lijie , Jin Shaohua , Chen Shusen , Jiao Qingze 
Published: January 2012

AbstractCrystals of γ‐HNIW were transformed into crystals of ε‐HNIW by application of a drowning‐out process in the presence of different additives, namely ethylene glycol, triacetin, and aminoacetic acid. They show different effects on the crystal morphology of ε‐HNIW and cause less angular and more regular structures. Investigation of the sensitivities of the different ε‐HNIW crystals shows that their angles and regularity have an influence on the impact sensitivity. Aminoacetic acid selectively inhibits the growth of individual ε‐HNIW crystal faces to modify the morphology into spherical shape, these ε‐HNIW crystals are of much lower sensitivity, even compared with general RDX and HMX explosives.
Persistent photoconductivity in ZnO nanostructures induced by surface oxygen vacancy
Authors: Yin Z. G. , Zhang X. W. , Fu Z. , Yang X. L. , Wu J. L. , Wu G. S. , Gong L. , Chu Paul K. 
Published: January 2012

AbstractZnO nanowall networks grown on SiO2/Si substrate were found to exhibit persistent photoconductivity (PPC). The relaxation rate of the persistent photocurrent is enhanced by a higher oxygen level in the ambient suggesting that PPC is closely related to the ZnO surface. Surface modification with hydrogen peroxide can significantly reduce the PPC relaxation time, implying that surface oxygen deficiency is responsible for the effect. The transition between the neutral and the metastable singly ionized states of the surface oxygen vacancy is suggested to account for the phenomenon and it is supported by the temperature and wavelength dependence of the PPC. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Functionalization of Amorphous SiO2 and 6H‐SiC(0001) Surfaces with Benzo[ghi]perylene‐1,2‐dicarboxylic Anhydride via an APTES Linker
Authors: Bhowmick Deb Kumar , Linden Steffen , Devaux André , De Cola Luisa , Zacharias Helmut 
Published: January 2012

AbstractThe successful covalent functionalization of quartz and n‐type 6H‐SiC with organosilanes and benzo[ghi]perylene‐1,2‐dicarboxylic dye is demonstrated. In particular, wet‐chemically processed self‐assembled layers of aminopropyltriethoxysilane (APTES) and benzo[ghi]perylene‐1,2‐dicarboxylic anhydride are investigated. The structural and chemical properties of these layers are studied by contact angle measurements, attenuated total reflection infrared (ATR‐IR) spectroscopy, and X‐ray photoelectron spectroscopy (XPS). The optical properties are measured by confocal microscopy. The wetting angles observed for the organic layers are α = 68° for the APTES‐functionalized surface, while angles of α = 85° and 78° are determined for dye‐functionalized quartz and 6H‐SiC surfaces, respectively. However, not all amino groups of the APTES‐functionalized surfaces react to bind dye molecules. Further dye functionalization is not uniform throughout the surface, showing different island sizes of the dye and including different chemical environments. The quartz surface exhibits a higher packing density of dyes than the 6H‐SiC surface. The fluorescence lifetimes of the surface‐attached dye show double exponential decays of about 1.4 and 4.2 ns, largely independent of the substrates.