bluuebunny/crossref_metadata_2025_split huggingface dataset:
Climatology of Anticyclonic and Cyclonic Rossby Wave Breaking on the Dynamical Tropopause in the Southern Hemisphere
Authors: Song Jie , Li Chongyin , Pan Jing , Zhou Wen 
Published: October 2010

Abstract
The characteristics of the climatological distribution of the anticyclonic (LC1) and cyclonic (LC2) Rossby wave breaking (RWB) in the Southern Hemisphere (SH) are investigated by calculating the occurrence frequency of the LC1- and LC2-like stratospheric potential vorticity (PV) streamers in the SH during the austral summer [December–February (DJF)] and wintertime [June–August (JJA)] on several isentropic surfaces by using the 40-yr European Centre for Medium-Range Weather Forecasts (ECMWF) Re-Analysis (ERA-40) daily dataset. The results show that 1) on the equatorward flank of the climatological midlatitude jet (MLJ), the LC1-like PV streamers are frequently found over the central oceanic regions, whereas the LC2-like PV streamers are almost absent. On the poleward flank of the climatological MLJ, both types of PV streamers are frequently observed and the LC2-like PV streamers predominate; 2) the regions where the occurrences of the PV streamers are frequent overlap the weak zonal wind regions; and 3) in austral winter, a “double-jet” setting is evident in two regions of the SH [the double-jet upstream (DU) and the spilt jet region]. In the double-jet setting regions, the LC1-like PV streamers are frequently found both in the DU and the split-jet regions, while the occurrence of the LC2-like PV streamers is frequent in the split-jet region but is rather infrequent in the DU region.
Critical Evaluation of the ISCCP Simulator Using Ground-Based Remote Sensing Data
Authors: Mace Gerald G. , Houser Stephanie , Benson Sally , Klein Stephen A. , Min Qilong 
Published: October 2010

Abstract
Given the known shortcomings in representing clouds in global climate models (GCMs), comparisons with observations are critical. The International Satellite Cloud Climatology Project (ISCCP) diagnostic products provide global descriptions of cloud-top pressure and column optical depth that extend over multiple decades. Given the characteristics of the ISCCP product, the model output must be converted into what the ISCCP algorithm would diagnose from an atmospheric column with similar physical characteristics. This study evaluates one component of this so-called ISCCP simulator by comparing ISCCP results with simulated ISCCP diagnostics that are derived from data collected at the Atmospheric Radiation Measurement Program (ARM) Southern Great Plains (SGP) Climate Research Facility. It is shown that if a model were to simulate the cloud radiative profile with the same accuracy as can be derived from the ARM data, the likelihood of that occurrence being classified with similar cloud-top pressure and optical depth as ISCCP would range from 30% to 70% depending on optical depth. The ISCCP simulator improved the agreement of cloud-top pressure between ground-based remote sensors and satellite observations, and we find only minor discrepancies because of the parameterization of cloud-top pressure in the ISCCP simulator. The differences seem to be primarily due to discrepancies between satellite and ground-based sensors in the visible optical depth. The source of the optical depth bias appears to be due to subpixel cloud field variability in the retrieval of optical depths from satellite sensors. These comparisons suggest that caution should be applied to comparisons between models and ISCCP observations until the differences in visible optical depths are fully understood. The simultaneous use of ground-based and satellite retrievals in the evaluation of model clouds is encouraged.
Changes to the North Atlantic Subtropical High and Its Role in the Intensification of Summer Rainfall Variability in the Southeastern United States
Authors: Li Wenhong , Li Laifang , Fu Rong , Deng Yi , Wang Hui 
Published: October 2010

Abstract
This study investigates the changes of the North Atlantic subtropical high (NASH) and its impact on summer precipitation over the southeastern (SE) United States using the 850-hPa geopotential height field in the National Centers for Environmental Prediction (NCEP) reanalysis, the 40-yr European Centre for Medium-Range Weather Forecasts (ECMWF) Re-Analysis (ERA-40), long-term rainfall data, and Intergovernmental Panel on Climate Change (IPCC) Fourth Assessment Report (AR4) model simulations during the past six decades (1948–2007). The results show that the NASH in the last 30 yr has become more intense, and its western ridge has displaced westward with an enhanced meridional movement compared to the previous 30 yr. When the NASH moved closer to the continental United States in the three most recent decades, the effect of the NASH on the interannual variation of SE U.S. precipitation is enhanced through the ridge’s north–south movement. The study’s attribution analysis suggested that the changes of the NASH are mainly due to anthropogenic warming. In the twenty-first century with an increase of the atmospheric CO2 concentration, the center of the NASH would be intensified and the western ridge of the NASH would shift farther westward. These changes would increase the likelihood of both strong anomalously wet and dry summers over the SE United States in the future, as suggested by the IPCC AR4 models.
Diapycnal Mixing in the Antarctic Circumpolar Current
Authors: Ledwell J. R. , St. Laurent L. C. , Girton J. B. , Toole J. M. 
Published: October 2010

Abstract
The vertical dispersion of a tracer released on a density surface near 1500-m depth in the Antarctic Circumpolar Current west of Drake Passage indicates that the diapycnal diffusivity, averaged over 1 yr and over tens of thousands of square kilometers, is (1.3 ± 0.2) × 10−5 m2 s−1. Diapycnal diffusivity estimated from turbulent kinetic energy dissipation measurements about the area occupied by the tracer in austral summer 2010 was somewhat less, but still within a factor of 2, at (0.75 ± 0.07) × 10−5 m2 s−1. Turbulent diapycnal mixing of this intensity is characteristic of the midlatitude ocean interior, where the energy for mixing is believed to derive from internal wave breaking. Indeed, despite the frequent and intense atmospheric forcing experienced by the Southern Ocean, the amplitude of finescale velocity shear sampled about the tracer was similar to background amplitudes in the midlatitude ocean, with levels elevated to only 20%–50% above the Garrett–Munk reference spectrum. These results add to a long line of evidence that diapycnal mixing in the interior middepth ocean is weak and is likely too small to dictate the middepth meridional overturning circulation of the ocean.
Sea Surface Roughness and Drag Coefficient as Functions of Neutral Wind Speed
Authors: Hersbach Hans 
Published: October 2010

Abstract
Near the surface, it is commonly believed that the behavior of the (turbulent) atmospheric flow can be well described by a constant stress layer. In the case of a neutrally stratified surface layer, this leads to the well-known logarithmic wind profile that determines the relation between near-surface wind speed and magnitude of stress. The profile is set by a surface roughness length, which, over the ocean surface, is not constant; rather, it depends on the underlying (ocean wave) sea state. For instance, at the European Centre for Medium-Range Weather Forecasts this relation is parameterized in terms of surface stress itself, where the scale is set by kinematic viscosity for light wind and a Charnock parameter for strong wind. For given wind speed at a given height, the determination of the relation between surface wind and stress (expressed by a drag coefficient) leads to an implicit equation that is to be solved in an iterative way.
In this paper a fit is presented that directly expresses the neutral drag coefficient and surface roughness in terms of wind speed without the need for iteration. Since the fit is formulated in purely dimensionless quantities, it is able to produce accurate results over the entire range in wind speed, level height, and values for the Charnock parameter for which the implicit set of equations is believed to be valid.
Eastern North Pacific Hurricane Season of 2009
Authors: Kimberlain Todd B. , Brennan Michael J. 
Published: October 2010

Abstract
The 2009 eastern North Pacific hurricane season had near normal activity, with a total of 17 named storms, of which seven became hurricanes and four became major hurricanes. One hurricane and one tropical storm made landfall in Mexico, directly causing four deaths in that country along with moderate to severe property damage. Another cyclone that remained offshore caused an additional direct death in Mexico. On average, the National Hurricane Center track forecasts in the eastern North Pacific for 2009 were quite skillful.
Oxygenated hypothermic pulsatile perfusion versus cold static storage for kidneys from non heart-beating donors tested by in-line ATP resynthesis to establish a strategy of preservation
Authors: Buchs Jean-Bernard , Lazeyras Francois , Ruttimann Raphael , Nastasi Antonio , Morel Phillipe 
Published: October 2010

Aim: The scarcity of kidneys for transplantation impels an expansion of the donor source to include the use of organs from Maastricht II and Maastricht I non heart-beating donors. The aim of this study was to establish the best method to preserve kidneys from non heart-beating donors (NHBD): cold static storage (CSS) or perfusion. ATP production during kidney preservation has been retained as a measure of their energetic levels and, consequently, their viability. The presence of warm ischemia with both types of preservation was studied. Methods: Porcine kidneys presenting no warm ischemia or 30 minutes of warm ischemia were submitted to immediate oxygenated hypothermic pulsatile perfusion or immediate cold static storage. The study was divided into four groups. ATP resynthesis was measured after 8 h. of perfusion. ATP was assessed by in-line 31P nuclear magnetic resonance spectroscopy (NMRS) during the preservations. Results: Only oxygenated perfusion could restore ATP in organs with warm ischemia. Initial cold static storage seems deleterious on organs having suffered from warm ischemia. Discussion: Only oxygenated perfusion could restore ATP in organs with warm ischemia. Initial cold static storage seems deleterious to organs having suffered from warm ischemia. Oxygenated perfusion must be introduced immediately after kidney removal from non heart-beating donors. In organs without warm ischemia, any kind of preservation is equivalent.
Pathological basis of diffusely abnormal white matter: insights from magnetic resonance imaging and histology
Authors: Laule Cornelia , Vavasour Irene M , Leung Esther , Li David KB , Kozlowski Piotr , Traboulsee Anthony L , Oger Joel , MacKay Alex L , Moore GR Wayne 
Published: October 2010

Background: The pathological basis of diffusely abnormal white matter (DAWM) in multiple sclerosis (MS) has not been elucidated in detail, but may be an important element in disability and clinical progression. Methods: Fifty-three subjects with MS were examined with T1, multi-echo T2 and magnetization transfer (MT). Twenty-three samples of formalin-fixed MS brain tissue were examined with multi-echo T2 and subsequently stained for myelin phospholipids using luxol fast blue, for axons using Bielschowsky, immunohistochemically for the myelin proteins myelin basic protein (MBP) and 2′,3′-cyclic nucleotide 3′ phosphohydrolase (CNP) and for astrocytes using glial fibrillary acidic protein (GFAP). Regions of interest in DAWM were compared with normal appearing white matter. Results: Fourteen of 53 subjects with MS in the in vivo study showed the presence of DAWM. Subjects with DAWM were found to have a significantly lower Expanded Disability Status Scale (EDSS) and shorter disease duration (DD) when compared with subjects without DAWM (EDSS: 1.5 versus 3.0, p = 0.031; DD: 5.4 versus 10.3 years, p = 0.045). DAWM in vivo had reduced myelin water and MT ratio, and increased T2 and water content. Histological analysis suggests DAWM, which shows a reduction of the myelin water fraction, is characterized by selective reduction of myelin phospholipids, but with a relative preservation of myelin proteins and axons. Conclusions: These findings suggest that the primary abnormality in DAWM is a reduction or perturbation of myelin phospholipids that correlates with a reduction of the myelin water fraction.
Gender effects on intramuscular interferon beta-1a in relapsing–remitting multiple sclerosis: analysis of 1406 patients
Authors: Rudick RA , Kappos L , Kinkel R , Clanet M , Phillips JT , Herndon RM , Sandrock AW , Munschauer FE 
Published: October 2010

Background: We aimed to evaluate effects of gender on efficacy and safety of intramuscular (IM) interferon beta (IFNβ)-1a in patients with relapsing–remitting MS (RRMS) or clinically isolated syndromes (CIS) characteristic of early MS. Methods: Pooled data from 1406 (1027 women; 379 men) patients enrolled in five clinical studies of IM IFNβ-1a were analyzed. One analysis examined data for all patients treated with IM IFNβ-1a from all studies. Separate analyses were conducted of pooled IM IFNβ-1a-treated groups from all studies and pooled IFNβ-1a-treated and placebo-treated patients from the placebo-controlled studies. Outcome measures included time to first relapse, annualized relapse rate, time to disability progression, number of gadolinium-enhanced lesions, adverse events, laboratory evaluations, and neutralizing antibodies. Results: All efficacy assessments indicated similar treatment effects of IM IFNβ-1a in men and women with no significant treatment-by-gender interactions. Women reported more headaches, urinary tract infections, and depression in the analysis; however, these were also common in women who received placebo. Men reported more frequent flu-like symptoms in the placebo-controlled studies only. There were no other differences in the safety profile of IM IFNβ-1a between men and women. Conclusions: We conclude that no significant gender-related differences were found in the efficacy and safety of IM IFNβ-1a in patients with RRMS or CIS.
Exercise improves hemodynamic profiles and increases red blood cell concentrations of purine nucleotides in a rodent model
Authors: Yeung Pollen K.F. , Dauphinee Julie , Gouzoules Thera , Simonson Krista , Schindler Christoph 
Published: October 2010

Objective: To study the effect of exercise on hemodynamic profiles and red blood cell (RBC) concentrations of adenosine-5'-triphosphate (ATP). Methods: Male Sprague-Dawley (SD) rats (n = 9) were exercised on a treadmill for 15 min at a speed of 10 m/min with a 5% gradient after an hour settling down in a restrainer. Blood samples were collected via an indwelling carotid artery catheter using a ‘Stopping Solution’ from each rat before, during and after exercise. Hemodynamic recordings were collected continuously throughout the experiment. Concentrations of ATP and other purine nucleotides in the RBCs were determined by a validated high-performance liquid chromatography (HPLC) assay. A control group (n = 12) was treated the same way except without the exercise. Data between groups were analyzed by analysis of variance (ANOVA) and Student’s t-test, and differences were considered significant when p < 0.05. Results: Exercise increased systolic blood pressure (SBP; 141±23 vs. 132±17 mmHg) and heart rate (HR; 420±33 vs. 397±41 bpm), but decreased diastolic blood pressure (DBP; 105±18 vs. 110±14 mmHg). This was followed by a postexercise condition when SBP, DBP, and HR were decreased for the remainder of the experiment. RBC concentrations of ATP and guanosine-5'-triphosphate (GTP) increased significantly during exercise and continued to increase for 5 hours postexercise (1.5±0.75 vs. 0.96 vs. 0.36 mM for ATP; and 0.14±0.061 vs. 0.058±0.030 mM) (p < 0.05). Conclusion: Exercise increased RBC ATP concentrations in a rodent model, which was correlated with the decrease in BP and HR postexercise.
SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse
Authors: Ou Xuan , Chae Hee-Don , Wang Rui-Hong , Shelley William C. , Cooper Scott , Taylor Tammi , Kim Young-June , Deng Chu-Xia , Yoder Mervin C. , Broxmeyer Hal E. 
Published: October 2010

AbstractSIRT1 is a founding member of a sirtuin family of 7 proteins and histone deacetylases. It is involved in cellular resistance to stress, metabolism, differentiation, aging, and tumor suppression. SIRT1−/− mice demonstrate embryonic and postnatal development defects. We examined hematopoietic and endothelial cell differentiation of SIRT1−/− mouse embryonic stem cells (ESCs) in vitro, and hematopoietic progenitors in SIRT1+/++/−, and −/− mice. SIRT1−/− ESCs formed fewer mature blast cell colonies. Replated SIRT1−/− blast colony-forming cells demonstrated defective hematopoietic potential. Endothelial cell production was unaltered, but there were defects in formation of a primitive vascular network from SIRT1−/−-derived embryoid bodies. Development of primitive and definitive progenitors derived from SIRT1−/− ESCs were also delayed and/or defective. Differentiation delay/defects were associated with delayed capacity to switch off Oct4, Nanog and Fgf5 expression, decreased β-H1 globin, β-major globin, and Scl gene expression, and reduced activation of Erk1/2. Ectopic expression of SIRT1 rescued SIRT1−/− ESC differentiation deficiencies. SIRT1−/− yolk sacs manifested fewer primitive erythroid precursors. SIRT1−/− and SIRT1+/− adult marrow had decreased numbers and cycling of hematopoietic progenitors, effects more apparent at 5%, than at 20%, oxygen tension, and these progenitors survived less well in vitro under conditions of delayed growth factor addition. This suggests a role for SIRT1 in ESC differentiation and mouse hematopoiesis.
Three decades of transplantation for chronic myeloid leukemia: what have we learned?
Authors: Pavlů Jiří , Szydlo Richard M. , Goldman John M. , Apperley Jane F. 
Published: October 2010

Abstract
Last year marked 30 years of hematopoietic stem cell transplantation as a curative treatment of chronic myeloid leukemia (CML). Initially studies used stem cells from identical twins but techniques rapidly developed to use cells first from HLA-identical siblings and later unrelated donors. During the 1990s CML became the most frequent indication for allogeneic transplantation worldwide. This, together with the relative biologic homogeneity of CML in chronic phase, its responsiveness to graft-versus-leukemia effect and the ability to monitor low level residual disease placed CML at the forefront of research into different strategies of stem cell transplantation. The introduction of BCR-ABL1 tyrosine kinase inhibitors during the last decade resulted in long-term disease control in the majority of patients with CML. In those who fail to respond and/or develop intolerance to these agents, transplantation remains an effective therapeutic solution. The combination of tyrosine kinase inhibitors with transplantation is an exciting new strategy and it provides inspiration for similar approaches in other malignancies.
Design and conduct of Caudwell Xtreme Everest: an observational cohort study of variation in human adaptation to progressive environmental hypoxia
Authors: Levett Denny ZH , Martin Daniel S , Wilson Mark H , Mitchell Kay , Dhillon Sundeep , Rigat Fabio , Montgomery Hugh E , Mythen Monty G , Grocott Michael PW ,   for the Caudwell Xtreme Everest Research Group
Published: October 2010

Abstract

Background
The physiological responses to hypoxaemia and cellular hypoxia are poorly understood, and inter-individual differences in performance at altitude and outcome in critical illness remain unexplained. We propose a model for exploring adaptation to hypoxia in the critically ill: the study of healthy humans, progressively exposed to environmental hypobaric hypoxia (EHH). The aim of this study was to describe the spectrum of adaptive responses in humans exposed to graded EHH and identify factors (physiological and genetic) associated with inter-individual variation in these responses.

Methods
Design: Observational cohort study of progressive incremental exposure to EHH.

Setting
University human physiology laboratory in London, UK (75 m) and 7 field laboratories in Nepal at 1300 m, 3500 m, 4250 m, 5300 m, 6400 m, 7950 m and 8400 m.

Participants
198 healthy volunteers and 24 investigators trekking to Everest Base Camp (EBC) (5300 m). A subgroup of 14 investigators studied at altitudes up to 8400 m on Everest.

Main outcome measures
Exercise capacity, exercise efficiency and economy, brain and muscle Near Infrared Spectroscopy, plasma biomarkers (including markers of inflammation), allele frequencies of known or suspected hypoxia responsive genes, spirometry, neurocognitive testing, retinal imaging, pupilometry. In nested subgroups: microcirculatory imaging, muscle biopsies with proteomic and transcriptomic tissue analysis, continuous cardiac output measurement, arterial blood gas measurement, trans-cranial Doppler, gastrointestinal tonometry, thromboelastography and ocular saccadometry.

Results
Of 198 healthy volunteers leaving Kathmandu, 190 reached EBC (5300 m). All 24 investigators reached EBC. The completion rate for planned testing was more than 99% in the investigator group and more than 95% in the trekkers. Unique measurements were safely performed at extreme altitude, including the highest (altitude) field measurements of exercise capacity, cerebral blood flow velocity and microvascular blood flow at 7950 m and arterial blood gas measurement at 8400 m.

Conclusions
This study demonstrates the feasibility and safety of conducting a large healthy volunteer cohort study of human adaptation to hypoxia in this difficult environment. Systematic measurements of a large set of variables were achieved in 222 subjects and at altitudes up to 8400 m. The resulting dataset is a unique resource for the study of genotype:phenotype interactions in relation to hypoxic adaptation.
Balancing Sound Strength and Reverberation Time in Small Concert Halls by Means of Variable Acoustics
Authors: Aretz Marc , Orlowski Raf 
Published: October 2010

Sound strength G is a measure of the physical sound level in a concert hall and is closely related to the subjective sensation of loudness. It has been measured in six small concert halls in Cambridge, UK, in combination with measurements of reverberation time. The aim is to investigate the relationship between sound strength and reverberation time in small halls and to study the effect of variable acoustics in these halls. Large ensembles in small halls are often too loud and it is desirable to reduce the sound level. This can be done by introducing acoustically absorbent material but the reverberation time is also decreased. Reverberation time cannot be decreased by an arbitrary amount as it is closely related to sound quality. Therefore, reverberation time and strength have to be carefully balanced in order to maintain sufficient reverberance whilst at the same time avoiding excessive loudness. The study also compares measured strength levels with values derived from traditional and revised theories for strength calculations [1]. Measured strength levels were consistently lower than theoretical predictions and possible reasons for this are discussed with reference to design features of the halls and objective acoustics parameters.