bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Interesting Case of Lung Mass
Authors: Attili Venkata Satya Suresh , Reddy C Obula 
Published: July 2009

ABSTRACTA 46-year-male smoker presented with cough and fever to a chest physician, who on the basis of chest X-ray started him on antitubercular treatment. However, further evaluation suggested that the patient was suffering from a rare disease, i.e. Anaplastic large cell lymphoma of lung. Although lung involvement in cases of lymphoma is observed in as high as 40% of cases, in autopsy series, the exact clinical incidence is not known. One of the largest lymphoma groups reported it to be around 25%. However, primary pulmonary lymphomas have been extremely rare (0.4%), and whenever present they are of (Mucosa Associate Lymphoid tissue) MALT type, with occasional diffuse large cell lymphomas. The anaplastic variant is extremely uncommon. Usually the treatment results are satisfactory with more than 80% of the cases surviving even after 3 years. Here we report the case of anaplastic primary nonHodgkin′s lymphoma of lung and review the literature.
Perovskite oxide absorbents for oxygen separation
Authors: He Yufeng , Zhu Xuefeng , Li Qiming , Yang Weishen 
Published: July 2009

AbstractThe fixed‐bed oxygen absorption processes of the series of Ba1−xSrxCo0.8Fe0.2O3−δ oxides were studied by oxygen partial pressure swing absorption in the temperature range of 300–850°C. The results show that SrCo0.8Fe0.2O3−δ, with the smallest A‐site ion radius, has the largest oxygen absorption capacity (0.402 mmol/g) at 500°C. The oxygen absorption and desorption kinetics fit well with the pseudo‐second‐order kinetics model. Comparing the modeling absorption rate coefficient k2 with the desorption rate coefficient k2′, all the oxides studied had higher oxygen absorption rates than oxygen desorption ones. In addition, the combined results of X‐ray diffraction analysis, O2‐TPD, room temperature iodometric titration, and thermogravimetric analysis explained the relationship between the oxygen absorption capacities and the average radii of the A‐site ions for this series of Ba1−xSrxCo0.8Fe0.2O3−δ in the temperature range of 300–600°C. © 2009 American Institute of Chemical Engineers AIChE J, 2009
The course and correlates of high hospital utilization in sickle cell disease: Evidence from a large, urban Medicaid managed care organization
Authors: Carroll C. Patrick , Haywood Carlton , Fagan Peter , Lanzkron Sophie 
Published: July 2009

AbstractAlthough most patients with sickle cell disease (SCD) are hospitalized infrequently and manage painful crises at home, a small subpopulation is frequently admitted to emergency departments and inpatient units. This small group accounts for the majority of health care expenses for patients with SCD. Using inpatient claims data from a large, urban Medicaid MCO for 5 consecutive years, this study sought to describe the course of high inpatient utilization (averaging four or more admissions enrolled per year for at least 1 year) in members with a diagnosis of SCD and a history of hospitalizations for vaso‐occlusive crisis. High utilizers were compared with the other members with SCD on demographics, medical and psychiatric comorbidity, and use of other health care resources. Members who were high utilizers had more diagnostic mentions of sickle cell complications than low utilizers. However, the pattern of high inpatient utilization was likely to moderate over successive years, and return to the pattern after moderation was uncommon. Despite this, a small subpopulation engaged in exceptional levels of inpatient utilization over multiple years. Am. J. Hematol., 2009. © 2009 Wiley‐Liss, Inc.
Hydrogen Peroxide Induces G2 Cell Cycle Arrest and Inhibits Cell Proliferation in Osteoblasts
Authors: Li Ming , Zhao Li , Liu Jun , Liu An‐Ling , Zeng Wei‐Sen , Luo Shen‐Qiu , Bai Xiao‐Chun 
Published: July 2009

AbstractReactive oxygen species (ROSs) are involved in osteoporosis by inhibiting osteoblastic differentiation and stimulating osteoclastgenesis. Little is known about the role and how ROS controls proliferation of osteoblasts. Mammalian target of rapamycin, mTOR, is a central regulator of cell growth and proliferation. Here, we report for the first time that 5–200 μM hydrogen peroxide (H2O2) dose‐ and time‐dependently suppressed cell proliferation without affecting cell viability in mouse osteoblast cell line, MC3T3‐E1, and in human osteoblast‐like cell line, MG63. Further study revealed that protein level of cyclin B1 decreased markedly and the percentage of the cells in G2/M phase increased about 2‐4 fold by 200 μM H2O2 treatment for 24–72 hr. A total of 0.5–5 mM of H2O2 but not lower concentrations (5–200 μM) of H2O2 inhibited mTOR signaling, as manifested by dephosphorylation of S6K (T389), 4E‐BP1 (T37/46), and S6(S235/236) in MC3T3‐E1 and MG63 cells. Rapamycin, which could inhibit mTOR signaling and cell proliferation, however, did not reduce the protein level of cyclin B1. In a summary, H2O2 prevents cell proliferation of osteoblasts by down‐regulating cyclin B1 and inducing G2 cell cycle arrest. Inhibition of mTOR signaling by H2O2 may not be involved in this process. Anat Rec, 292:1107–1113, 2009. © 2009 Wiley‐Liss, Inc.
Gefitinib Inhibits the Proliferation of Pancreatic Cancer Cells via Cell Cycle Arrest
Authors: Zhou Xiaohua , Zheng Maqing , Chen Fang , Zhu Yunxia , Yong Wei , Lin Haiyan , Sun Yujie , Han Xiao 
Published: July 2009

AbstractHigh expression of the epidermal growth factor receptor (EGFR) has been implicated in the development of pancreatic cancer. Gefitinib is an orally active and selective EGFR‐TKI (EGFR‐tyrosine kinase inhibitor) that blocks signal transduction pathways responsible for the proliferation and survival of cancer cells, and other host‐dependent processes promoting cancer growth. This study investigated the anticancer effect of gefitinib on human pancreatic cancer cells and the molecular mechanism involved. We first evaluated the effect of gefitinib on cell proliferation with MTT assay and the results demonstrated that gefitinib significantly inhibited the proliferation of pancreatic cancer cells. Flow cytometric analysis showed that gefitinib induced a delay in cell cycle progression and a G0/G1 arrest together with a G2/M block; these were associated with increased expression of p27Kip1 cyclin‐dependent kinase inhibitor combined with decreased expression of aurora B. Besides, luciferase reporter assay revealed that transcriptional mechanism was responsible for the down‐regulation of aurora B protein by gefitinib. Overall, the results suggest a mechanistic connection among these events to provide new insights into the mechanism underlying the antiproliferative effect of gefitinib on pancreatic cancer and supplement a theory basis of gefitinib in clinical treatment of pancreatic cancer. Anat Rec, 292:1122–1127, 2009. © 2009 Wiley‐Liss, Inc.
The Microanatomy of the Palatine Tonsils of the One‐Humped Camel (Camelus dromedarius)
Authors: Zidan Mohamed , Pabst Reinhard 
Published: July 2009

AbstractTonsils form a first line of defense against foreign antigens and are also a route of entry and a replication site for some pathogens. The palatine tonsils are the largest of all the tonsils. Despite their general importance, little is known about the microanatomy of the palatine tonsils of the one‐humped camel. Palatine tonsils of 10 clinically healthy male camels were obtained directly after slaughtering for human consumption. The tonsils were examined macroscopically and by light, scanning, and transmission electron microscopy. Palatine tonsils had the unique form of several spherical macroscopic nodules protruding into the pharyngeal lumen. These spherical masses were numerous and close together in the lateral oropharyngeal wall, with a few solitary nodules in the dorsal wall. Each nodule had one or two apical openings to crypts, and was enclosed by an incomplete connective tissue capsule and covered apically with stratified squamous keratinized epithelium. The tonsillar crypt was lined with stratified squamous non keratinized epithelium. Several lymphocytes infiltrated the epithelial layer, forming patches of reticular epithelium. Lymphoid follicles with obvious germinal centers extended under the epithelial surface. Diffusely localized lymphocytes were seen in the interfollicular region. High endothelial venules, dendritic cells, macrophages, and plasma cells were observed among these lymphocytes. The unique arrangement of palatine tonsils in separate units with individual crypts results in a very large surface exposed to antigen and indicates a significant immunological role of palatine tonsils in the camel. Anat Rec, 292:1192–1197, 2009. © 2009 Wiley‐Liss, Inc.
Expression of KiSS‐1 Gene and its Role in Invasion and Metastasis of Human Hepatocellular Carcinoma
Authors: Shengbing Zang , Jing Feng Liu , Bin Wang , Lingyun Gao , Aimin Huang 
Published: July 2009

AbstractKiSS‐1 has been identified as a putative metastasis‐suppressor gene in human melanomas and breast cancer cell lines. Although loss of KiSS‐1 expression has been associated with progression and poor prognosis of various cancers, the exact role of KiSS‐1 expression in HCC is not well‐defined. Our study investigated KiSS‐1 expression levels in HCC and its role in invasion and metastasis of human HCC. The expression levels of KiSS‐1 and MMP‐9 protein were determined by tissue microarray (TMA) serial sections, immunohistochemistry and semi‐quantitative image analysis. All clinical and histological data obtained were subjected to statistical analysis. The expression of KiSS‐1 protein in HCC and intrahepatic metastasis lesions was significantly lower (P < 0.01) when compared with non‐tumor liver tissue and normal liver tissue. Multivariate analysis revealed a significant inverse correlation between KiSS‐1 expression and ○1
TNM stage, (F = 7.113, P < 0.01) and
○2intrahepatic metastasis (t = 2.898, P < 0.01). Loss of KiSS‐1 in intrahepatic metastasis versus primary carcinomas was statistically significant (P<0.01). We also found a negative correlation between KiSS‐1 and MMP‐9 expression in HCC (r = ‐0.506, P < 0.01). We conclude that loss of KiSS‐1 during HCC metastasis, along with a concomitant upregulation of MMP‐9 suggests a possible mechanism for cell motility and invasion during HCC metastasis, with KiSS‐1 emerging as a possible therapeutic target during HCC metastasis. Anat Rec, 292:1128–1134, 2009. © 2009 Wiley‐Liss, Inc.
Blood Flow Patterns Spatially Associated with Platelet Aggregates in Murine Colitis
Authors: Miele Lino F. , Turhan Aslihan , Lee Grace S. , Lin Miao , Ravnic Dino , Tsuda Akira , Konerding Moritz A. , Mentzer Steven J. 
Published: July 2009

AbstractIn the normal murine mucosal plexus, blood flow is generally smooth and continuous. In inflammatory conditions, such as chemically‐induced murine colitis, the mucosal plexus demonstrates markedly abnormal flow patterns. The inflamed mucosal plexus is associated with widely variable blood flow velocity as well as discontinuous and even bidirectional flow. To investigate the mechanisms responsible for these blood flow patterns, we used intravital microscopic examination of blood flow within the murine mucosal plexus during dextran sodium sulphate‐and trinitrobenzenesulfonic acid‐induced colitis. The blood flow patterns within the mucosal plexus demonstrated flow exclusion in 18% of the vessel segments (P < 0.01). Associated with these segmental exclusions was significant variation in neighboring flow velocities. Intravascular injection of fluorescent platelets demonstrated platelet incorporation into both fixed and rolling platelet aggregates. Rolling platelet aggregates (mean velocity 113 μm/sec; range, 14–186 μm/sec) were associated with reversible occlusions and flow variations within the mucosal plexus. Gene expression profiles of microdissected mucosal plexus demonstrated enhanced expression of genes for CCL3, CXCL1, CCL2, CXCL5, CCL7, CCL8, and Il‐1b (P < 0.01), and decreased expression of CCL6 (P < 0.01). These results suggest that platelet aggregation, activated by the inflammatory mileau, contributes to the complex flow dynamics observed in acute murine colitis. Anat Rec, 292:1143–1153, 2009. © 2009 Wiley‐Liss, Inc.
Predictors of early inactive disease in a juvenile idiopathic arthritis cohort: Results of a Canadian multicenter, prospective inception cohort study
Authors: Oen Kiem , Tucker Lori , Huber Adam M. , Miettunen Paivi , Scuccimarri Rosie , Campillo Sarah , Cabral David A. , Feldman Brian M. , Tse Shirley , Chédeville Gaëlle , Spiegel Lynn , Schneider Rayfel , Lang Bianca , Ellsworth Janet , Ramsey Suzanne , Dancey Paul , Silverman Earl , Chetaille Anne‐Laure , Cameron Bonnie , Johnson Nicole , Dorval Jean , Petty Ross E. , Duffy Karen Watanabe , Boire Gilles , Haddad Elie , Houghton Kristin , Saint‐Cyr Claire , Turvey Stuart E. , Benseler Susanne , Cheang Mary , Yeung Rae S. M. , Duffy Ciarán M. 
Published: July 2009

AbstractObjectiveTo determine early predictors of 6‐month outcomes in a prospective cohort of patients with juvenile idiopathic arthritis (JIA).MethodsPatients selected were those enrolled in an inception cohort study of JIA, the Research in Arthritis in Canadian Children Emphasizing Outcomes Study, within 6 months after diagnosis. The juvenile rheumatoid arthritis core criteria set and quality of life measures were collected at enrollment and 6 months later. Outcomes evaluated included inactive disease, Juvenile Arthritis Quality of Life Questionnaire (JAQQ) scores, and Childhood Health Assessment Questionnaire (C‐HAQ) scores at 6 months.ResultsThirty‐three percent of patients had inactive disease at 6 months. Onset subtype and most baseline core criteria set measures correlated with all 3 outcomes. Relative to oligoarticular JIA, the risks of inactive disease were lower for enthesitis‐related arthritis, polyarthritis rheumatoid factor (RF)–negative JIA, and polyarthritis RF‐positive JIA, and were similar for psoriatic arthritis. In multiple regression analyses, the baseline JAQQ score was an independent predictor of all 3 outcomes. Other independent baseline predictors included polyarthritis RF‐negative and systemic JIA for inactive disease; C‐HAQ score and polyarthritis RF‐positive JIA for the 6‐month C‐HAQ score; and active joint count, pain, and time to diagnosis for the 6‐month JAQQ score.ConclusionClinical measures soon after diagnosis predict short‐term outcomes for patients with JIA. The JAQQ is a predictor of multiple outcomes. Time to diagnosis affects quality of life in the short term.
The effects of impaired joint position sense on the development and progression of pain and structural damage in knee osteoarthritis
Authors: Felson David T. , Gross K. Douglas , Nevitt Michael C. , Yang Mei , Lane Nancy E. , Torner James C. , Lewis Cora E. , Hurley Michael V. 
Published: July 2009

AbstractObjectiveAlthough cross‐sectional studies have reported impaired proprioceptive acuity in people with osteoarthritis (OA), there have been no longitudinal studies to evaluate whether those with such impairments increase the risk of OA or its worsening.MethodsWe studied subjects from the Multicenter Osteoarthritis Study study, a longitudinal study of people with or at high risk of knee OA. At baseline, we quantified acuity as the amount of a subject's error when attempting to reproduce a test knee flexion angle (a measure of joint position sense). We tested proprioception 10 times in the right leg and used a person's worst score as their proprioceptive acuity. At baseline and the 30‐month followup, we assessed the presence of frequent pain, obtained Western Ontario and McMasters Universities OA Index (WOMAC) scores, and acquired posteroanterior and lateral weight‐bearing knee radiographs read for Kellgren/Lawrence grade and individual radiographic features. We examined the relation of baseline proprioceptive acuity in quartiles with baseline knee pain (frequent pain yes/no), WOMAC pain score, self‐reported physical function, and radiographic OA, and with changes from baseline in pain, physical function, and radiographic OA adjusted for age, sex, body mass index, and quadriceps strength.ResultsAt baseline, proprioceptive acuity was associated with the presence and severity of knee pain but not with the presence of radiographic OA. However, among the 2,243 subjects with baseline acuity assessments and 30‐month followup, there were no strong associations between proprioceptive acuity and development of adverse OA outcomes. Acuity was not significantly associated with the new onset of frequent knee pain. Those with the worst acuity at baseline had slightly greater worsening of WOMAC pain scores (0.47 on a 20‐point scale) and physical function scores (by 1.5 points on a 0–68‐point scale) compared with those with the best proprioceptive acuity, whose pain and physical function score deteriorated less (for pain P = 0.05; for physical function P = 0.02). Radiographic worsening was not significantly associated with proprioceptive acuity.ConclusionProprioceptive acuity as assessed by the accuracy of reproduction of the angle of knee flexion had modest effects on the trajectory of pain and physical functional limitation in knee OA.
Noninvasive imaging techniques in the assessment of scleroderma spectrum disorders
Authors: Murray Andrea K. , Moore Tonia L. , Manning Joanne B. , Taylor Christopher , Griffiths Christopher E. M. , Herrick Ariane L. 
Published: July 2009

AbstractObjectiveSystemic sclerosis (SSc) affects both microvascular structure and function. Laser Doppler imaging (LDI) and thermal imaging can be used to measure cutaneous blood vessel function. Nailfold capillaroscopy (NC) measures capillary morphology. The aim of this study was to investigate the relationship between capillary morphology and blood flow, and to determine which combination of techniques allows the best discrimination between patients with SSc, primary Raynaud's phenomenon (RP), and healthy controls.MethodsNC was performed in 16 patients with SSc, 14 patients with primary RP, and 16 healthy controls. In addition, participants underwent cold stimulus with cold water. Hands were imaged to monitor rewarming and reperfusion. Nailfold morphologic features were measured and baseline images and rewarming curves were analyzed.ResultsSignificant differences were found between groups (analysis of variance) for capillary morphologic features and rewarming curve characteristics. A correlation (P < 0.001) was found between LDI and thermal imaging at baseline (0.667) and maximum (0.729) blood flow and skin temperature, and for the areas under the rewarming curves (0.684). Receiver operating characteristic curves indicated that NC, thermal imaging, and LDI allowed 89%, 74%, and 72%, respectively, of SSc patient data to be correctly classified versus primary RP patients and controls.ConclusionNC, LDI, and thermal imaging each independently provide good discrimination between patients with SSc and those with primary RP and healthy controls (NC being the most suitable technique for classifying patient groups). However, a combination of all 3 techniques improves classification. LDI and thermal imaging give equivalent information on dynamic changes in the cutaneous microcirculation; however, these only weakly correspond to capillary morphology.
Depression, inflammation, and pain in patients with rheumatoid arthritis
Authors: Kojima Masayo , Kojima Toshihisa , Suzuki Sadao , Oguchi Takeshi , Oba Michinari , Tsuchiya Hiroki , Sugiura Fumiaki , Kanayama Yasuhide , Furukawa Toshiaki A. , Tokudome Shinkan , Ishiguro Naoki 
Published: July 2009

AbstractObjectiveAn association between depression and inflammation has been suggested. In patients with rheumatoid arthritis (RA), pain is a major symptom associated with depression and inflammation. We examined the independent associations between depression, the inflammation marker C‐reactive protein (CRP) level, and pain in patients with RA.MethodsIn total, 218 RA outpatients completed self‐administered questionnaires, using the Beck Depression Inventory II to measure depressive symptoms and a visual analog scale to quantify their perceived pain. Functional disability and CRP level were also measured.ResultsDepression scores were mildly and positively correlated with the CRP level (r = 0.46, P < 0.001). Both the depression score (standardized β = 0.35, P < 0.001) and the CRP level (standardized β = 0.35, P < 0.001) were significantly associated with pain, even after adjustment for clinical covariates in regression analysis. In logistic analysis, the combined effects on the risk of severe pain (pain score in the upper tertile) increased with depression scores and CRP levels linearly.ConclusionDepression severity and inflammation were associated with each other and appeared to have independent effects on perceived pain. Therefore, a clinical approach that takes into account both the body and the mind could have benefits and could enable optimal pain control.
Hypoxia and glucocorticoid signaling converge to regulate macrophage migration inhibitory factor gene expression
Authors: Elsby Laura M. , Donn Rachelle , Alourfi Zaynab , Green Laura M. , Beaulieu Elaine , Ray David W. 
Published: July 2009

AbstractObjectiveMacrophage migration inhibitory factor (MIF) is a proinflammatory mediator involved in the pathogenesis of rheumatoid arthritis. This study was undertaken to identify the MIF promoter elements responsible for regulating gene expression.MethodsLuciferase reporter gene assays were used to identify the MIF promoter sequence responsible for basal activity. Bioinformatic analysis was used to predict transcription factor binding sites, and electrophoretic mobility shift assay (EMSA) was used to demonstrate transcription factor binding. Chromatin immunoprecipitation (ChIP) was used to demonstrate transcription factor loading on the MIF promoter.ResultsWe identified the minimal promoter sequence required for basal MIF promoter activity that was also capable of conferring glucocorticoid‐dependent inhibition in a T lymphocyte model cell line. Deletion studies and EMSA revealed 2 elements in the MIF promoter that were responsible for basal promoter activity. The 5′ element binds CREB/activating transcription factor 1, and the 3′ element is a functional hypoxia‐responsive element binding hypoxia‐inducible factor 1α. Further studies demonstrated that the cis elements are both required for glucocorticoid‐dependent inhibition. ChIP demonstrated glucocorticoid‐dependent recruitment of glucocorticoid receptor α to the MIF promoter in lymphocytes within 1 hour of treatment and a concomitant decrease in acetylated histone H3.ConclusionOur findings indicate that hypoxia and glucocorticoid signaling converge on a single element regulating MIF; this regulatory unit is a potential interacting node for microenvironment sensing of oxygen tension and glucocorticoid action in foci of inflammation.