bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gap1 functions as a molecular chaperone to stabilize its interactive partner Gap3 during biogenesis of serine‐rich repeat bacterial adhesin
Authors: Zhou Meixian , Zhu Fan , Li Yirong , Zhang Hua , Wu Hui 
Published: January 2012

SummarySerine‐rich repeat glycoproteins (SRRPs) are important bacterial adhesins that are conserved in streptococci and staphylococci. Fimbriae‐associated protein (Fap1) from Streptococcus parasanguinis, was the first SRRP identified; it plays an important role in bacterial biofilm formation. A gene cluster encoding glycosyltransferases and accessory secretion components is required for Fap1 biogenesis. Two glycosylation‐associated proteins, Gap1 and Gap3 within the cluster, interact with each other and function in concert in Fap1 biogenesis. Here we report the new molecular events underlying contribution of the interaction to Fap1 biogenesis. The Gap1‐deficient mutant rendered Gap3 unstable and degraded in vitro and in vivo. Inactivation of a gene encoding protease ClpP reversed the phenotype of the gap1 mutant, suggesting that ClpP is responsible for degradation of Gap3. Molecular chaperone GroEL was co‐purified with Gap3 only when Gap1 was absent and also reacted with Gap1 monoclonal antibody, suggesting that Gap1 functions as a specific chaperone for Gap3. The N‐terminal interacting domains of Gap1 mediated the Gap3 stability and Fap1 biogenesis. Gap1 homologues from Streptococcus agalactiae and Staphylococcus aureus also interacted with and stabilized corresponding Gap3 homologues, suggesting that the chaperone activity of the Gap1 homologues is common in biogenesis of SRRPs.
The assessment of quality of life in female Turkish patients with overactive bladder
Authors: Sut Hatice Kahyaoglu , Kaplan Petek Balkanli , Sut Necdet , Tekbas Serap 
Published: January 2012

Kahyaoglu Sut H, Balkanli Kaplan P, Sut N, Tekbas S. International Journal of Nursing Practice 2012; 18: 20–27The assessment of quality of life in female Turkish patients with overactive bladderThe objective of this study was to examine the quality of life in female Turkish patients with overactive bladder (OAB). The investigation was conducted as a cross‐sectional study between January and April 2010. Two hundred eighty female patients responded to the Overactive Bladder Validated Eight‐Question Screener, the OAB disease‐specific health‐related quality‐of‐life scale (OAB questionnaire (OAB‐q)) and the general quality‐of‐life scale EuroQol Five‐Dimensional Questionnaire (EQ‐5D) for the study. Of the 280 patients, 38.9% was classified as having OAB. The mean age was 47.0 ± 8.7. All of the quality‐of‐life domains (coping, concern, sleep and social) and OAB‐q total scores in women with OAB were significantly worse than in women without OAB (P < 0.001 for all). Similarly, the EQ‐5Dindex and EQ‐5DVAS scores for women with OAB were significantly worse than for women without OAB (P < 0.001 and P = 0.006, respectively). OAB‐q and EQ‐5Dindex scores in menopausal women were significantly lower than non‐menopausal women (P < 0.05) in patients with OAB. In conclusion, OAB negatively affects quality of life in Turkish women. However, many women's quality of life can be improved if the patients seek medical treatment. Thus, nurses should encourage the patients to seek medical support in order to cope with health‐related quality‐of‐life problems.
Efficacy of frequent blood pressure and heart rate monitoring for early identification of bleeding following percutaneous coronary intervention
Authors: Mert Hatice , Seren Intepeler Seyda , Bengu Nergiz , Baturlar Zuhal , Istan Pakize , Ozcelik Ebru 
Published: January 2012

Mert H, Intepeler Seren S, Bengu N, Baturlar Z, Istan P, Ozcelik E. International Journal of Nursing Practice 2012; 18: 52–59Efficacy of frequent blood pressure and heart rate monitoring for early identification of bleeding following percutaneous coronary interventionMonitoring of patients' vital signs is an important component of postpercutaneous coronary intervention (post‐PCI) for bleeding early detection. This study was performed in order to identify the efficacy of frequent blood pressure (BP) and heart rate (HR) monitoring for early identification of bleeding following PCI. The descriptive study was conducted at the cardiology unit of a university hospital with a study sample of 1292 patients. Data collection instruments were designed by the authors. In a comparison of the presence of abnormal BP‐HR between the groups with and without bleeding, the difference was not significant on arrival and not at 15, 45 and 60 min posttransfer. There is no association between the frequent vital sign measurement in the first hour and early diagnosis of bleeding. The frequency of follow up after PCI should be based on the patient's condition, the nurse's clinical expertise and the institutional protocols.
Nurses' burnout and unmet nursing care needs of patients' relatives in a Turkish State Hospital
Authors: Tekindal Benian , Tekindal Mustafa Agah , Pinar Gul , Ozturk Filiz , Alan Sumeyra 
Published: January 2012

Tekindal B, Tekindal MA, Pinar G, Ozturk F, Alan S. International Journal of Nursing Practice 2012; 18: 68–76Nurses' burnout and unmet nursing care needs of patients' relatives in a Turkish State HospitalOne of the biggest problems of work life today is burnout. With burnout, satisfaction of clients and service givers reduces. In this study, burnout levels of nurses working in the internal, surgical and intensive care units of a university hospital and the unmet needs of the patients' relatives related to nursing care were investigated. In the study, 225 nurses and 222 relatives of patients constituted the sample group of this study. Three separate forms were used in the study, namely, Nurse and Patient Relative Identification Form, the Maslach Burnout Inventory and the Nursing Services Satisfaction Inventory. In the study, burnout levels of the nurses were found to be high. Conditions like younger ages, scarcity of experience in the profession, lower levels of education, having chosen the profession and the unit they work in not willingly and working in environments like intensive care increase the burnout and as a result, expectations of the relatives of patients from nursing care are not fully met. Some suggestions have been made to make some regulations to prevent the burnout of nurses and to increase the satisfaction of relatives.
The use of multidose vials and fingerstick blood sampling devices in Korean emergency departments and intensive care units
Authors: Kwak Yee Gyung , Lee Sang‐Oh , Kim Tae Hyong , Choo Eun Ju , Jeon Min‐Hyok , Jun Jae‐Bum , Kim Kyung‐Mi , Jeong Jae Sim , Kim Yang Soo 
Published: January 2012

Kwak YG, Lee S‐O, Kim TH, Choo EJ, Jeon M‐H, Jun J‐B, Kim K‐M, Jeong JS, Kim YS. International Journal of Nursing Practice 2012; 18: 77–83The use of multidose vials and fingerstick blood sampling devices in Korean emergency departments and intensive care unitsThis study was performed to compare compliance with standard precautions for the use of multidose vials (MDVs) and fingerstick devices in emergency departments (EDs) and intensive care units (ICUs). Between December 2007 and February 2008, 389 nurses from the EDs or ICUs of six university‐affiliated hospitals in Korea were asked to complete the questionnaire. A total of 338 (86.9%) nurses completed the survey, corresponding to 159 of 184 ED and 179 of 205 ICU nurses. A comparison of MDV use in EDs and ICUs indicated a significant difference only in disinfection of the rubber septum of heparin vials; 88.1% of ED nurses and 96.6% of ICU nurses stated that they always disinfected the rubber septum of heparin vials whenever drawing medication (P = 0.003). The use of separate fingerstick devices for each patient (71.7% vs. 54.5%) and disinfection of these devices after each use (36.5% vs. 26.0%) were more common in ED nurses. The rate of good hand hygiene was lower in ED nurses, both before (43.7% vs. 74.3%) and after (64.6% vs. 91.6%) the use of fingerstick devices (P < 0.001 for both). There is a need to improve compliance with standard precautions, especially hand hygiene, in EDs.
The health‐care environment through the eyes of a child—Does it soothe or provoke anxiety?
Authors: Norton‐Westwood Deborah 
Published: January 2012

Norton‐Westwood D. International Journal of Nursing Practice 2012; 18: 7–11The health‐care environment through the eyes of a child—Does it soothe or provoke anxiety?Health‐care environments can be intimidating and scary places especially in the eyes of a child. When attempting to create spaces that are engaging to children, how do we know what works and are the needs the same across the age groups? In a 2011 comprehensive systematic review, a total of 20 studies were reviewed to answer the question: Can the health‐care environment have an impact on children's anxiety? The results of the review showed that the built environment can support and enhance the coping strategies utilized by children, however further research is needed. The aim of this article is to summarize the findings of the review highlighting simple design strategies of minimal cost to large construction projects warranting extensive resources.Careful evaluation of space incorporating end‐user input can result in age appropriate environments that support safe, quality care and enhance a positive health‐care experience for all.
Psychometric evaluation of the Norwegian version of the Person‐centred Care Assessment Tool
Authors: Rokstad Anne Marie Mork , Engedal Knut , Edvardsson David , Selbæk Geir 
Published: January 2012

Rokstad AMM, Engedal K, Edvardsson D, Selbæk G. International Journal of Nursing Practice 2012; 18: 99–105Psychometric evaluation of the Norwegian version of the Person‐centred Care Assessment ToolThe Person‐centred Care Assessment Tool (P‐CAT) was developed as a self‐reporting assessment scale for staff ratings of the person‐centredness of their nursing practice.This study investigates the psychometric properties of P‐CAT in a sample of staff working in residential units for older people.Descriptive characteristics were calculated for each item and an independent‐sample t‐test was used to compare ratings from different groups. Internal consistency and reliability were examined using the Cronbach's alpha coefficient. Exploratory factor analysis was used to evaluate construct validity. Test–retest reliability was examined by means of intra‐class correlation and the Pearson correlation coefficient.The mean score of P‐CAT was 45.3 (standard deviation 7.8). Cronbach's alpha was 0.83. The factor analysis resulted in a two‐component solution organizing the items into two subscales. There were significant differences between ordinary care units and special‐care units and between various occupational groups, indicating a discriminating ability of the tool.
Nature and intensity of the pain following thoracotomy
Authors: Kol Emine , Erdogan Abdullah , Karslı Bilge 
Published: January 2012

Kol E, Erdogan A, Karslı B. International Journal of Nursing Practice 2012; 18: 84–90Nature and intensity of the pain following thoracotomyThe aim of this study is to clearly define and describe the pain characteristics that disturb the patients having thoracotomy in postoperative period. It can be possible to manage to get pains under control according to pain characteristics. The study included 70 patients who underwent thoracotomy (lobectomy or segmentectomy and mean duration of surgery was 90 min) and were hospitalized in the intensive care unit of the Thoracic Surgery Department of Akdeniz University Hospital between November 2007 and November 2008. In this study, 68.6% of the patients were male and mean age was 49.90. The study was achieved. Consider that the patients have pain in the first 24 h postoperatively and the effect of sedation, the Behavioural Pain Scale, which is filled out by a researcher, and the Verbal Category Scale, which allows the patient to define his/her pain with short responses, were used for pain assessment. Pain was assessed at the postoperative 4th, 8th, 16th, 24th and 48th hours, following extubation. The patients mostly reported throbbing (65.7%), stabbing (65.7%) and stinging (62.9%) pain in the incision site, while 40% of them (n = 28) reported a ‘sharp’, ‘exhausting’ and ‘splitting’ pain. The investigation of the factors increasing pain during the postoperative period revealed that most of the patients (85.7%) reported that their pain increased due to movement in bed and/or walking, while 74.3%, 68.6%, 54.3% and 37.1% of them stated that their pain increased due to breathing, coughing, chest tube movement and noisy environment, respectively. Each pain characteristics, throbbing, stabbing and stinging, can be specifically relief using one or more methods such as touching on the incision site, little press on the thoracotomy region, talking to the patient about pain, etc. We determined that the patients experienced a sharp, stabbing and unbearable pain in the first 48 postoperative hours. Therefore, our study suggests that some interventions such as pressure exertion and touching to the painful area were stated to provide pain relief to the patients.
Is the Chronic Kidney Disease Epidemiology Collaboration four‐level race equation better than the cystatin C equation?
Authors: DU XIN , LIU LIN , HU BO , WANG FENG , WAN XIN , JIANG LINGLIN , ZHANG RUISHENG , CAO CHANGCHUN 
Published: January 2012

ABSTRACTAim:  To evaluate the Chronic Kidney Disease Epidemiology Collaboration (CKD‐EPI) four‐level race equation in the assessment of glomerular filtration rate (GFR) in Chinese people with chronic kidney disease (CKD), which was published in 2011, compared with the cystatin C‐based GFR estimation equation (CysC GFR) and the combination of CysC and serum creatinine equation (CysC‐Scr GFR).Methods:  The CKD‐EPI four‐level race equation estimated GFR (CKD‐EPI GFR) was compared with the CysC GFR and CysC‐Scr GFR. Three equations were compared with body surface area (BSA) standardized GFR (sGFR), which was measured by 99mTc‐DTPA renal dynamic imaging method in 111 CKD cases.Results:  A statistically significant correlation was found between sGFR and CKD‐EPI GFR, CysC GFR and CysC‐Scr GFR. Three estimated GFR (eGFR) equations of 30% accuracy were 58.6%, 56.8% and 63.5%, respectively. Average deviations of eGFR from sGFR were 2.34, 1.19, and 1.32 (mL/min per 1.73 m2) (P > 0.05), respectively. There was no significant deviation in the CKD from stages 1 to 5 in CKD‐EPI GFR and CysC‐Scr GFR. However, when estimated by CysC GFR, the deviation was increased, with the value of 12.41 mL/min per 1.73 m2 (P= 0.002) in CKD stage 5.Conclusion:  Our results showed that in a Chinese population with CKD, CKD‐EPI GFR, CysC GFR and CysC‐Scr GFR of bias and overall accuracy of 30% were very similar. There was little advantage in adding Asian coefficient to modifying the CKD‐EPI equation. CysC GFR overestimated GFR in patients with CKD stages 4 and 5.
Negative impact of migraine on quality of life after 4 weeks of treatment in patients with major depressive disorder
Authors: Hung Ching‐I , Liu Chia‐Yih , Yang Ching‐Hui , Wang Shuu‐Jiun 
Published: January 2012

Aim:  The impact of migraine on health‐related quality of life (HRQoL) among patients with major depressive disorder (MDD) after acute antidepressant treatment has not been addressed. The aim of the present study was to investigate whether or not the negative impact of migraine on HRQoL among outpatients with MDD continued to have an effect after 4 weeks of venlafaxine treatment.Methods:  A total of 135 outpatients with MDD were enrolled, who were then treated with venlafaxine 75 mg per day for 4 weeks in the present open‐label study. Migraine was diagnosed based on the International Classification of Headache Disorders (2nd edn). Changes in Short‐Form 36 (SF‐36) and Hamilton Depression Rating Scale (HAMD) scores were the outcome measures. Multiple linear regression was used to assess whether migraine was an independent factor predicting SF‐36 score after treatment.Results:  Seventy‐two participants (18M/54F) completed the 4‐week treatment. Subjects with migraine had a poorer HRQoL in terms of bodily pain and mental health at baseline. Subjects with and without migraine showed significant improvement in all SF‐36 subscales and depression after treatment, but subjects with migraine still had a poorer HRQoL regarding bodily pain and physical functioning after treatment as compared with those without migraine. Migraine could predict a negative outcome after treatment in the subscales of physical functioning, role limitations–physical, and role limitations–emotional.Conclusions:  Migraine may have a negative impact on the improvement of partial SF‐36 subscales, especially on functional recovery, after acute treatment among outpatients with MDD. Whether additional intervention besides antidepressant treatment for migraine is indicated may need further study.
Acute and transient psychotic disorders versus persistent delusional disorders: A comparative longitudinal study
Authors: Pillmann Frank , Wustmann Tobias , Marneros Andreas 
Published: January 2012

Aim:  The aim of this work is to investigate differences between two non‐schizophrenic, non‐organic psychotic disorders, namely persistent delusional disorders (PDD) and acute and transient psychotic disorders (ATPD) according to ICD‐10.Method:  In a prospective and longitudinal study, we compared all 43 inpatients with PDD who were treated at Halle‐Wittenberg University Hospital during a 14‐year period to a previously investigated cohort of 41 patients with ATPD in regard to demography, long‐term symptomatic outcome, and social consequences. Sociobiographical data were collected using a semi‐structured interview. Follow‐up investigations were performed at a mean of 10–12 years after the onset of the disorder using standardized instruments.Results:  With the exception of the duration of the psychotic symptoms, the PDD patients were significantly different from the ATPD patients on various levels, such as sex ratio (female predominance only in ATPD), age at onset (older in PDD), the number of preceding stressful life‐events in the index hospitalization (more frequent in ATPD), richness and variety of symptoms (higher in ATPD), and persistence of positive psychotic symptoms (in PDD). Patients with PDD had significantly less re‐hospitalizations during the course of their illness. Long‐term outcome was marked by chronicity of delusional symptoms and lower global functioning in PDD than in ATPD, while negative symptoms and loss of independence were infrequent in both conditions.Conclusions:  PDD differs from ATPD not only in the duration of the psychotic symptoms, but also in a variety of significant variables. They appear to be two separate entities within a psychotic spectrum.
Hyperprolactinemia induced by low‐dosage amisulpride in Korean psychiatric patients
Authors: Lee Bun‐Hee , Kang Seung‐Gul , Kim Tae‐Woo , Lee Heon‐Jeong , Yoon Ho‐Kyoung , Park Young‐Min 
Published: January 2012

Aim:  Amisulpride at low dosages enhances dopaminergic neurotransmission by preferentially blocking presynaptic D2/D3 receptors. Thus, low dosages of amisulpride are expected not to increase prolactin levels. The aim of this study was to examine whether low dosages of amisulpride can increase serum levels of prolactin or not clinically in Korean patients.Method:  Serum prolactin levels were measured in 20 Korean patients (12 men and eight women) with various diagnoses who were treated with less than 300 mg of amisulpride per day.Results:  The mean dosage of amisulpride was 195.0 ± 51.0 mg/day, and serum level of prolactin was 76.1 ± 43.4 ng/mL. The prolactin level was significantly higher in women (110.7 ± 49.3 ng/mL) than in men (53.1 ± 15.9 ng/mL) after administering amisulpride (P = 0.021), while the dosage of amisulpride did not differ significantly between men (200.0 ± 42.6 mg/day) and women (187.5 ± 64.1 mg/day) (P = 0.576).Conclusions:  The low dosages of amisulpride elevate serum prolactin level in the majority of patients. This finding indicates that the dose‐reduction of amisulpride has little effect to relieve amisulpride‐induced hyperprolactinemia at therapeutic dosages. Clinicians should monitor serum prolactin level even when low dosages of amisulpride are administered.
Evaluation of the chronic obstructive pulmonary disease assessment test for measurement of health‐related quality of life in patients with interstitial lung disease
Authors: NAGATA KAZUMA , TOMII KEISUKE , OTSUKA KOJIRO , TACHIKAWA RYO , OTSUKA KYOKO , TAKESHITA JUNPEI , TANAKA KOSUKE , MATSUMOTO TAKESHI , MONDEN KAZUYA 
Published: January 2012

ABSTRACTBackground and objective:  A well‐validated instrument that is simple to use is needed to assess health‐related quality of life in patients with interstitial lung disease (ILD). The COPD assessment test (CAT) is a recently introduced, short and simple questionnaire for COPD patients, which shows good and valid measurement properties. This study was conducted to evaluate the validity of the CAT in patients with ILD.Methods:  Patients with ILD (n = 55) completed the CAT and the St. George's Respiratory Questionnaire (SGRQ). These patients also completed the Medical Research Council (MRC) dyspnoea scale, the Leicester Cough Questionnaire (LCQ), and the hospital anxiety and depression scale; performed 6‐min walk tests and pulmonary function tests; and provided samples for arterial blood gas analysis.Results:  There was a very strong correlation between the CAT score and the SGRQ total score (r = 0.93, P < 0.0001). The CAT score was also significantly correlated with the SGRQ symptoms score (r = 0.74, P < 0.0001), the SGRQ activity score (r = 0.87, P < 0.0001) and the SGRQ impact score (r = 0.89, P < 0.0001). Stepwise multiple regression analysis demonstrated that the MRC and LCQ scores contributed most to both the CAT score and the SGRQ total score.Conclusions:  The CAT is a short and simple questionnaire that shows good and valid measurement properties for assessing the health status of patients with ILD.