bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hemodynamic Impairment of Blood Pressure and Stroke Mechanisms in Symptomatic Intracranial Atherosclerotic Stenosis
Authors: Chen Zimo , Liu Jia , Wang Anqi , Wu Bokai , Cheng Zaiheng , Jiang Yingyu , Gu Hongqiu , Ding Lingling , Mo Jinglin , Jiang Yong , Liu Liping , Jing Lina , Jing Jing , Wang Yilong , Zhao Xingquan , Wang Yongjun , Qin Haiqiang , Li Zixiao 
Published: June 2024

BACKGROUND:
Hemodynamic impairment of blood pressure may play a crucial role in determining the mechanisms of stroke in symptomatic intracranial atherosclerotic stenosis). We aimed to elucidate this issue and assess the impacts of modifications to blood pressure on hemodynamic impairment.

METHODS:
From the Third China National Stroke Registry III, computed fluid dynamics modeling was performed using the Newton-Krylov-Schwarz method in 339 patients with symptomatic intracranial atherosclerotic stenosis during 2015 to 2018. The major exposures were translesional systolic blood pressure (SBP) drop and poststenotic mean arterial pressure (MAP), and the major study outcomes were cortex-involved infarcts and borderzone-involved infarcts, respectively. Multivariate logistic regression models and the bootstrap resampling method were utilized, adjusting for demographics and medical histories.

RESULTS:

In all, 184 (54.3%) cortex-involved infarcts and 70 (20.6%) borderzone-involved infarcts were identified. In multivariate logistic model, the upper quartile of SBP drop correlated with increased cortex-involved infarcts (odds ratio, 1.92 [95% CI, 1.03–3.57]; bootstrap analysis odds ratio, 2.07 [95% CI, 1.09–3.93]), and the lower quartile of poststenotic MAP may correlate with increased borderzone-involved infarcts (odds ratio, 2.07 [95% CI, 0.95–4.51]; bootstrap analysis odds ratio, 2.38 [95% CI, 1.04–5.45]). Restricted cubic spline analysis revealed a consistent upward trajectory of the relationship between translesional SBP drop and cortex-involved infarcts, while a downward trajectory between poststenotic MAP and borderzone-involved infarcts. SBP drop correlated with poststenotic MAP negatively (r
s
=−0.765;
P
<0.001). In generating hemodynamic impairment, simulating blood pressure modifications suggested that ensuring adequate blood pressure to maintain sufficient poststenotic MAP appears preferable to the reverse approach, due to the prolonged plateau period in the association between the translesional SBP drop and cortex-involved infarcts and the relatively short plateau period characterizing the correlation between poststenotic MAP and borderzone-involved infarcts.

CONCLUSIONS:
This research elucidates the role of hemodynamic impairment of blood pressure in symptomatic intracranial atherosclerotic stenosis-related stroke mechanisms, underscoring the necessity to conduct hemodynamic assessments when managing blood pressure in symptomatic intracranial atherosclerotic stenosis.
Extracting reproducible subject-specific MEG evoked responses with independent component analysis
Authors: Cotroneo Silvia Federica , Ala-Salomäki Heidi , Parkkonen Lauri , Liljeström Mia , Salmelin Riitta 
Published: June 2024

Abstract
Reliable individual-level measures of neural activity are essential for capturing interindividual variability in brain activity recorded by magnetoencephalography (MEG). While conventional group-level analyses highlight shared features in the data, individual-level specificity is often lost. Current methods for assessing reproducibility of brain responses focus on group-level statistics and neglect subject-specific temporal and spatial characteristics. This study proposes a combined ICA algorithm (comICA), aimed at extracting within-individual consistent MEG evoked responses. The proposed hypotheses behind comICA are based on the temporal profiles of the evoked responses, the corresponding spatial information, as well as independence and linearity. ComICA is presented and tested against simulated data and test–retest recordings of a high-level cognitive task (picture naming). The results show high reliability in extracting the shared activations in the simulations (success rate &gt;93%) and the ability to successfully reproduce group-level results on reproducibility for the test–retest MEG recordings. Our model offers means for noise reduction, targeted extraction of specific activation components in experimental designs, and potential integration across different recordings.
Time-varying functional connectivity as Wishart processes
Authors: Kampman Onno P. , Ziminski Joe , Afyouni Soroosh , van der Wilk Mark , Kourtzi Zoe 
Published: June 2024

Abstract
We investigate the utility of Wishart processes (WPs) for estimating time-varying functional connectivity (TVFC), which is a measure of changes in functional coupling as the correlation between brain region activity in functional magnetic resonance imaging (fMRI). The WP is a stochastic process on covariance matrices that can model dynamic covariances between time series, which makes it a natural fit to this task. Recent advances in scalable approximate inference techniques and the availability of robust open-source libraries have rendered the WP practically viable for fMRI applications. We introduce a comprehensive benchmarking framework to assess WP performance compared with a selection of established TVFC estimation methods. The framework comprises simulations with specified ground-truth covariance structures, a subject phenotype prediction task, a test-retest study, a brain state analysis, an external stimulus prediction task, and a novel data-driven imputation benchmark. The WP performed competitively across all the benchmarks. It outperformed a sliding window (SW) approach with adaptive cross-validated window lengths and a dynamic conditional correlation (DCC)-multivariate generalized autoregressive conditional heteroskedasticity (MGARCH) baseline on the external stimulus prediction task, while being less prone to false positives in the TVFC null models.
Technology as Resistance: Pioneers of Korean Media Art from the 1960s to the 1990s
Authors: Shin Gyung Jin 
Published: June 2024

Abstract
This paper calls for a reassessment of early-stage Korean avant-garde and experimental art as the cornerstone of Korean media art. The aim is to discern a new genealogy of media art in Korea by tracing and linking the activities of early avant-garde artists and media art pioneers who have been neglected in the dominant art historiography, which has shown a preference for painting and video art. My detailed analysis of the experimental artists of the 1960s and 1970s, small groups in the mid-1980s, and the Art Tech Group in the early 1990s demonstrates how they revealed and articulated their spirit of resistance against academism and the mainstream using technology, thus following a different trajectory from that of the avant-garde and media art in Europe and North America.
Description of Longidorus sanlitanensis n. sp. (Dorylaimida: Longidoridae) from the rhizosphere of Melilotoides ruthenica and Chamaerhodos erecta in China
Authors: Cai Ruihang , Gu Jianfeng , Ye Weimin , Ma Xinxin , Liu Yinzhan 
Published: June 2024

Summary
Longidorus sanlitanensis n. sp. was recovered from the rhizosphere of Melilotoides ruthenica and Chamaerhodos erecta in the Inner Mongolia Autonomous Region, P.R. China, and was described and illustrated using morphological and molecular data. The new species is characterised by medium body length of females (4.0-4.8 mm), lip region anteriorly rounded and separated from the rest of the body by a depression, pocket-shaped amphidial pouches, the guiding ring located at 58.4-66.0 μm from the anterior end, odontostyle and odontophore 107.2-114.6 and 71.6-77.8 μm long, respectively, the pharyngeal bulb 68.7-79.7 μm long, a short conical tail with a broadly rounded terminus, four juvenile developmental stages (J1 was not detected) and males absent. By similarities in the distance of the guiding ring from the anterior body end, body and odontostyle length and lip region shape, the new species was compared with nine similar species, namely: L. litchi, L. diadecturus, L. fursti, L. himalayensis, L. jonesi, L. wiesae, L. macromucronatus, L. fangi and L. zhengi. The matrix code of the new species is: A4-B2-C5-D4-E1-F2-G2-H12-I2-J1-K?. The phylogenetic relationships of the new species with other relevant species were reconstructed using near-full-length 18S, ITS1 and 28S D2-D3 regions of rRNA gene and the resulted topologies were discussed. In 18S phylogeny, L. sanlitanensis n. sp. formed a clade with L. litchi inside a major clade, including species with a posteriorly located guiding ring, and in 28S phylogeny it showed close relationships with species having a posteriorly located guiding ring. This is the 22nd Longidorus species recorded from China.
Using closed-circuit infrared camera to assess biparental provisioning behaviour and foraging pattern of house-farmed swiftlets (Aerodramus sp.)
Authors: Daud Ummi Nur Syafiqah , Ismail Nor Adibah , Ramasamy Kosila , Arazmi Noor Fatihah Najihah , Md. Nor Shukor , Mansor Mohammad Saiful 
Published: June 2024

Abstract
The house-farmed edible-nest swiftlet (Aerodramus sp.) is monogamous, produces nests from hardened saliva, and uses echolocation to navigate in the darkness. Most previous studies have focused on swiftlet nest building and incubation behaviour, but nestling provisioning behaviour, crucial for the survival of offspring during the breeding season, remains unclear. This study examined the nestling provisioning behaviour of house-farmed swiftlets at a swiftlet house farm in central Peninsular Malaysia. Complete focal video footage of the provisioning phase of swiftlets was analysed in detail. The overall feeding period decreased as the chick grew older. The parents alternately visited their nest 6-14 times a day from dawn to dusk to feed the nestling. The peak of this activity was from 07:00 to 08:00 and between 19:00 and 20:00. Nestling provisioning behaviour differed between pairs. The egg-laying interval of parents with two chicks was longer and affected the development of the second chick since the first chick more successfully competed for food and grew larger in size. Most second chicks with a smaller body size did not survive, because of being either purposely or unintentionally eliminated by the parents or sibling. The smaller-sized second chicks that survived took a longer time to fledge than the first chick; therefore, parents had to increase their foraging effort to ensure the survival of their chick until fledging. These behaviours may be influenced by physiological factors, such as age, experience, individual fitness, and abiotic factors, such as weather and food resources; therefore, different parental strategies may be established during the nestling provisioning phase.
Judo 9+ injury prevention protocol (J9+IPP) on balance, strength, and anaerobic fitness in elite judokas: a one-group pretest-post-test, quasi-experimental trial
Authors: Rawat N. , Agarwal S. , Anwar U. 
Published: June 2024

Abstract
Judoka, the judo athlete, is involved in, high-intensity intermittent combat sport, to defeat the opponent by reversing body momentum with speed and skill. Hence the judokas are susceptible to injuries. Specific training and physical conditioning help the judoka perform efficiently with minimal risk of injuries. The judo9+ injury prevention protocol consisting of sport-specific exercises focuses on minimising lower limb risk factors. The objective of the study was to investigate the effects of judo 9+ injury prevention protocol on strength, balance, and anaerobic fitness in elite judokas. A sample of 20 (male and female elite judokas) aged between 20-40 years, were recruited in the study based on selection criteria. After demographic and baseline evaluation, the judo9+ injury prevention protocol was administered to each participant for four weeks (2 sessions/week). Balance (SEBT), lower limb strength (VJHT), and anaerobic fitness (SJFT) scores were administered before the training began and after the completion of the training. Pre-post-training changes were compared using, using the paired t-test. All the outcome measures, SEBT, VJHT and SJFT demonstrated statistical significant changes () following four weeks of judo9+ injury prevention training. Larger effect sizes of 0.94 and 1.42 with >90% power were reported in VJHT and SJFT, respectively. There is sufficient evidence from this study to confirm that judo9+ injury prevention training significantly improves lower limb strength and anaerobic fitness among elite judokas following four weeks of judo9+ injury prevention training. However, balance improvement might require longer duration.
A Comprehensive Review of Cogenerative Dialogue in Science Education
Authors: Baek Seongheui , Ha Yoon-Hee , Martin Sonya N. 
Published: June 2024

Abstract
This study comprehensively explores cogenerative dialogue in science education from a sociocultural perspective. Analyzing 120 papers and theses from January 2001 to December 2022 in Korean and English journals, we examine their objectives, themes, methods, learners, educational levels, participants, researcher roles, coteaching connections, and program durations. Our data analysis reveals growing diversity in cogenerative dialogue research objectives and subjects across countries. Consistent patterns emerge regarding researcher roles, participant groups, and program durations. This research offers insights into the evolving cogenerative dialogue landscape in science education, informing future investigations and highlighting trends in this field. The findings presented not only shed light on the current state of research but also provide direction for future investigations, highlighting trends and distinctive features in various facets of cogenerative dialogue-related studies. Specifically, we offer suggestions for the need for research in Korean science education contexts and more broadly in the Asia-Pacific region.
Exploring Children’s Reasoning about Continuous Causal Processes through Visual Cues and Non-Verbal Assessment in Science Education
Authors: Duan Jinruo , Yan Rong , Zare Samad , Qin Jike 
Published: June 2024

Abstract
Causal reasoning is important to children’s cognition and academic development. However, there have been few empirical studies on the impact of visual cues and non-verbal scaffolding on children’s reasoning in continuous causal processes. Hence, the present study aims to explore how causal reasoning in continuous processes is facilitated by visual mind maps and multiple-choice questions through science experiments. By randomly selecting 136 children aged 9–13, the following results were obtained: Children provided with a mind map containing visual causal cues performed significantly better than the non-cue group on explanation tasks regardless of age differences, and children assessed using non-verbal multiple-choice questions scored significantly higher in explaining causal relationships than those using only verbal reports. This suggests that identification and explanation need to be differentiated for a more accurate evaluation of causal reasoning ability. These results have valuable implications for science curriculum and pedagogy at primary schools.
Advanced glycation end product-modified low-density lipoprotein promotes pro-osteogenic reprogramming via RAGE/NF-κB pathway and exaggerates aortic valve calcification in hamsters
Authors: Yang Xi , Zeng Jingxin , Xie Kaiji , Su Shuwen , Guo Yuyang , Zhang Hao , Chen Jun , Ma Zhuang , Xiao Zezhou , Zhu Peng , Zheng Shaoyi , Xu Dingli , Zeng Qingchun 
Published: June 2024

Abstract
Background
Advanced glycation end product-modified low-density lipoprotein (AGE-LDL) is related to inflammation and the development of atherosclerosis. Additionally, it has been demonstrated that receptor for advanced glycation end products (RAGE) has a role in the condition known as calcific aortic valve disease (CAVD). Here, we hypothesized that the AGE-LDL/RAGE axis could also be involved in the pathophysiological mechanism of CAVD.

Methods
Human aortic valve interstitial cells (HAVICs) were stimulated with AGE-LDL following pre-treatment with or without interleukin 37 (IL-37). Low-density lipoprotein receptor deletion (Ldlr−/−) hamsters were randomly allocated to chow diet (CD) group and high carbohydrate and high fat diet (HCHFD) group.

Results
AGE-LDL levels were significantly elevated in patients with CAVD and in a hamster model of aortic valve calcification. Our in vitro data further demonstrated that AGE-LDL augmented the expression of intercellular cell adhesion molecule-1 (ICAM-1), interleukin-6 (IL-6) and alkaline phosphatase (ALP) in a dose-dependent manner through NF-κB activation, which was attenuated by nuclear factor kappa-B (NF-κB) inhibitor Bay11-7082. The expression of RAGE was augmented in calcified aortic valves, and knockdown of RAGE in HAVICs attenuated the AGE-LDL-induced inflammatory and osteogenic responses as well as NF-κB activation. IL-37 suppressed inflammatory and osteogenic responses and NF-κB activation in HAVICs. The vivo experiment also demonstrate that supplementation with IL-37 inhibited valvular inflammatory response and thereby suppressed valvular osteogenic activities.

Conclusions
AGE-LDL promoted inflammatory responses and osteogenic differentiation through RAGE/NF-κB pathway in vitro and aortic valve lesions in vivo. IL-37 suppressed the AGE-LDL-induced inflammatory and osteogenic responses in vitro and attenuated aortic valve lesions in a hamster model of CAVD.

Graphic Abstract
Targeted insertion of conditional expression cassettes into the mouse genome using the modified i-PITT
Authors: Miura Hiromi , Nakamura Ayaka , Kurosaki Aki , Kotani Ai , Motojima Masaru , Tanaka Keiko , Kakuta Shigeru , Ogiwara Sanae , Ohmi Yuhsuke , Komaba Hirotaka , Schilit Samantha L.P. , Morton Cynthia C. , Gurumurthy Channabasavaiah B. , Ohtsuka Masato 
Published: June 2024

Abstract
Background
Transgenic (Tg) mice are widely used in biomedical research, and they are typically generated by injecting transgenic DNA cassettes into pronuclei of one-cell stage zygotes. Such animals often show unreliable expression of the transgenic DNA, one of the major reasons for which is random insertion of the transgenes. We previously developed a method called “pronuclear injection-based targeted transgenesis” (PITT), in which DNA constructs are directed to insert at pre-designated genomic loci. PITT was achieved by pre-installing so called landing pad sequences (such as heterotypic LoxP sites or attP sites) to create seed mice and then injecting Cre recombinase or PhiC31 integrase mRNAs along with a compatible donor plasmid into zygotes derived from the seed mice. PITT and its subsequent version, improved PITT (i-PITT), overcome disadvantages of conventional Tg mice such as lack of consistent and reliable expression of the cassettes among different Tg mouse lines, and the PITT approach is superior in terms of cost and labor. One of the limitations of PITT, particularly using Cre-mRNA, is that the approach cannot be used for insertion of conditional expression cassettes using Cre-LoxP site-specific recombination. This is because the LoxP sites in the donor plasmids intended for achieving conditional expression of the transgene will interfere with the PITT recombination reaction with LoxP sites in the landing pad.

Results
To enable the i-PITT method to insert a conditional expression cassette, we modified the approach by simultaneously using PhiC31o and FLPo mRNAs. We demonstrate the strategy by creating a model containing a conditional expression cassette at the Rosa26 locus with an efficiency of 13.7%. We also demonstrate that inclusion of FLPo mRNA excludes the insertion of vector backbones in the founder mice.

Conclusions
Simultaneous use of PhiC31 and FLP in i-PITT approach allows insertion of donor plasmids containing Cre-loxP-based conditional expression cassettes.
Characterization of metallothionein genes from Broussonetia papyrifera: metal binding and heavy metal tolerance mechanisms
Authors: Xu Zhenggang , Yang Shen , Li Chenhao , Xie Muhong , He Yi , Chen Sisi , Tang Yan , Li Dapei , Wang Tianyu , Yang Guiyan 
Published: June 2024

Abstract
Background
Broussonetia papyrifera is an economically significant tree with high utilization value, yet its cultivation is often constrained by soil contamination with heavy metals (HMs). Effective scientific cultivation management, which enhances the yield and quality of B. papyrifera, necessitates an understanding of its regulatory mechanisms in response to HM stress.

Results
Twelve Metallothionein (MT) genes were identified in B. papyrifera. Their open reading frames ranged from 186 to 372 bp, encoding proteins of 61 to 123 amino acids with molecular weights between 15,473.77 and 29,546.96 Da, and theoretical isoelectric points from 5.24 to 5.32. Phylogenetic analysis classified these BpMTs into three subclasses: MT1, MT2, and MT3, with MT2 containing seven members and MT3 only one. The expression of most BpMT genes was inducible by Cd, Mn, Cu, Zn, and abscisic acid (ABA) treatments, particularly BpMT2e, BpMT2d, BpMT2c, and BpMT1c, which showed significant responses and warrant further study. Yeast cells expressing these BpMT genes exhibited enhanced tolerance to Cd, Mn, Cu, and Zn stresses compared to control cells. Yeasts harboring BpMT1c, BpMT2e, and BpMT2d demonstrated higher accumulation of Cd, Cu, Mn, and Zn, suggesting a chelation and binding capacity of BpMTs towards HMs. Site-directed mutagenesis of cysteine (Cys) residues indicated that mutations in the C domain of type 1 BpMT led to increased sensitivity to HMs and reduced HM accumulation in yeast cells; While in type 2 BpMTs, the contribution of N and C domain to HMs’ chelation possibly corelated to the quantity of Cys residues.

Conclusion
The BpMT genes are crucial in responding to diverse HM stresses and are involved in ABA signaling. The Cys-rich domains of BpMTs are pivotal for HM tolerance and chelation. This study offers new insights into the structure-function relationships and metal-binding capabilities of type-1 and − 2 plant MTs, enhancing our understanding of their roles in plant adaptation to HM stresses.