bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward Greater Clarity in Defining and Understanding Nonattachment
Authors: Tremblay Lindsay , Van Gordon William , Elander James 
Published: June 2024

AbstractNonattachment is a key positive element of several psychotherapeutic approaches, including mindfulness-based interventions. However, it has been defined in the academic literature largely as a construct of negation, whereby one should not become attached to objects, people, or experiences. This approach may foster resistance to nonattachment in general through confusion associated with what it means along with uncertainty in how to practise it as there are currently no evidence-based courses or clear guidelines. Furthermore, there is currently no empirical exploration of interventions that are specifically nonattachment-based in terms of their value in applied settings.The purpose of this paper is to propose an affirmative, action-based definition of nonattachment in order to improve understanding and implementation. A further objective is to provide examples of exercises within existing therapeutic modalities through which nonattachment may already be cultivated and to use the example of post-traumatic stress (PTS) as a focus area to discuss the potential value and implications of using nonattachment in a clinical context. Four psychotherapeutic approaches currently applying nonattachment-based concepts including Acceptance and Commitment Therapy, Dialectical Behavioural Therapy, Compassion-Focussed Therapy, and Mindfulness are critically assessed for ways in which they cultivate nonattachment, using symptoms of PTS as an example.Based on existing therapeutic and contemplative practices that embody nonattachment principles, as an affirmative definition we propose that nonattachment involves the intentional practices of acceptance, letting go, deep presence, opening to a universally interconnected self-schema, and perceptual distancing from stimuli and response. An affirmative understanding of what nonattachment is, along with a targeted approach to its cultivation, may facilitate a clearer pathway toward the predictive and intervention outcome value of nonattachment in applied settings.
Deciphering the role of zinc homeostasis in the tumor microenvironment and prognosis of prostate cancer
Authors: Guo Tao , Wang Jian , Meng Xiangyu , Wang Ye , Lou Yihaoyun , Ma Jianglei , Xu Shuang , Ni Xiangyu , Jia Zongming , Jin Lichen , Wang Chengyu , Chen Qingyang , Li Peng , Huang Yuhua , Ren Shancheng 
Published: June 2024

Abstract
Background
Dysregulation of zinc homeostasis is widely recognized as a hallmark feature of prostate cancer (PCa) based on the compelling clinical and experimental evidence. Nevertheless, the implications of zinc dyshomeostasis in PCa remains largely unexplored.

Methods
In this research, the zinc homeostasis pattern subtype (ZHPS) was constructed according to the profile of zinc homeostasis genes. The identified subtypes were assessed for their immune functions, mutational landscapes, biological peculiarities and drug susceptibility. Subsequently, we developed the optimal signature, known as the zinc homeostasis-related risk score (ZHRRS), using the approach won out in multifariously machine learning algorithms. Eventually, clinical specimens, Bayesian network inference and single-cell sequencing were used to excavate the underlying mechanisms of MT1A in PCa.

Results
The zinc dyshomeostasis subgroup, ZHPS2, possessed a markedly worse prognosis than ZHPS1. Moreover, ZHPS2 demonstrated a more conspicuous genomic instability and better therapeutic responses to docetaxel and olaparib than ZHPS1. Compared with traditional clinicopathological characteristics and 35 published signatures, ZHRRS displayed a significantly improved accuracy in prognosis prediction. The diagnostic value of MT1A in PCa was substantiated through analysis of clinical samples. Additionally, we inferred and established the regulatory network of MT1A to elucidate its biological mechanisms.

Conclusions
The ZHPS classifier and ZHRRS model hold great potential as clinical applications for improving outcomes of PCa patients.
Research Data Management in Simulation Science: Infrastructure, Tools, and Applications
Authors: Flemisch Bernd , Hermann Sibylle , Herschel Melanie , Pflüger Dirk , Pleiss Jürgen , Range Jan , Roy Sarbani , Takamoto Makoto , Uekermann Benjamin 
Published: June 2024

AbstractResearch Data Management (RDM) has gained significant traction in recent years, being essential to allowing research data to be, e.g., findable, accessible, interoperable, and reproducible (FAIR), thereby fostering collaboration or accelerating scientific findings. We present solutions for RDM developed within the DFG-Funded Cluster of Excellence EXC2075 Data-Integrated Simulation Science (SimTech). After an introduction to the scientific context and challenges faced by simulation scientists, we outline the general data management infrastructure and present tools that address these challenges. Exemplary domain applications demonstrate the use and benefits of the proposed data management software solutions. These are complemented by additional measures for enablement and dissemination to foster the adoption of these techniques.
Parametrizing W-weighted BT inverse to obtain the W-weighted q-BT inverse
Authors: Ferreyra D. E. , Thome N. , Torigino C. 
Published: June 2024

AbstractThe core-EP and BT inverses for rectangular matrices were studied recently in the literature. The main aim of this paper is to unify both concepts by means of a new kind of generalized inverse called W-weighted q-BT inverse. We analyze its existence and uniqueness by considering an adequate matrix system. Basic properties and some interesting characterizations are proved for this new weighted generalized inverse. Also, we give a canonical form of the W-weighted q-BT inverse by means of the weighted core-EP decomposition.
Genetic diversity of Apis mellifera complementary sex determiner (csd) in four Australian breeding populations
Authors: Mo Erica Y. Y. , Utaipanon Patsavee , Bates Tiffane , Davies John , Grueber Catherine E. , Lim Julianne , Frost Elizabeth A. , Chapman Nadine C. 
Published: June 2024

AbstractHoney bee (Apis mellifera) breeding has intensified as populations experience increasing stress and pollination demand increases. Breeding programmes risk genetic diversity losses as mating is focused on a small group of individuals. Loss of diversity at the complementary sex determiner (csd) locus results in decreased viability and reduced honey production. Bees that are homozygous at csd become inviable males rather than workers. We examined csd diversity in four Australian breeding populations: a queen bee breeder from New South Wales, another from Queensland, a Western Australian breeding programme involving 11 bee breeders, and a research population at the NSW Department of Primary Industries. We found 82 unique csd alleles across the four populations, 16 of which have not been previously reported. This study provides a snapshot of csd diversity in Australia which will be useful for the national honey bee genetic improvement programme (Plan Bee).
Development of a Proof-of-Concept Multi-Method Computer Simulation to Support Rural Healthcare Disaster Preparedness Planning
Authors: Berg Thomas A. , Kintziger Kristina W. , Crumly Julie Suzuki , Lawson Scott A. , Myers Carole R. , Stansberry Tracey T. 
Published: June 2024

AbstractDue to a lack of resources, rural communities often face challenges when planning catastrophic events. This project involved applying systems thinking and model-based systems engineering to develop a proof-of-concept, multi-method computer simulation and then determining whether the simulation could be used to assess the efficacy of disaster planning approaches on health outcomes in rural communities, as a function of primary healthcare. The project focus was a rural or non-urban healthcare system experiencing a natural hazard. Both system dynamics and discrete event models were incorporated to represent subsystem operations, crucial disaster responses, as well as three key response systems: public health, emergency management, and healthcare. The subsystem models included several components: policies/procedures, communications, resources, exercises/drills/training, healthcare space and staff, and the flow of affected people into and through the system. The combined simulation can serve as a first step to a more comprehensive approach to helping rural communities achieve more efficient and effective healthcare planning for disaster responses.
Grapevine (Vitis vinifera L.) Germplasm from Siena (Italy) Includes Rare Strains and Reveals Population Structuring
Authors: Vignani Rita , Scali Monica , Ciacci Andrea 
Published: June 2024

AbstractMolecular characterization was carried out on samples of historical grapevine populations that were gathered from within and around the medieval walls of Siena. Forty-nine grapevines were selected based on their age, historical site of growth, grapevines’ ampelography, and for being relict accessions, obsolete to cultivation. SSR profiling data were compared to 44 known grapevines, revealing six functional genetic groups with significant similarity to grapevine types generally grown in Tuscany. The Sienese germplasm is enriched with rare grapevines at risk of extinction, such as Zuccaccio, Gorgottesco, Tenerone, Prugnolo gentile, Occhio di Pernice, Procanico, Rossone, Mammolo, and Canina. Population genetics analysis revealed the existence of five subpopulations structure (-k5) in analogy with cluster analysis.
Location-Specific Microstructure Characterization Within AM Bench 2022 Laser Tracks on Bare Nickel Alloy 718 Plates
Authors: Levine L. E. , Williams M. E. , Stoudt M. R. , Weaver J. S. , Young S. A. , Deisenroth D. , Lane B. M. 
Published: June 2024

AbstractAdditive manufacturing of metal alloys produces microstructures that are typically very different from those produced by more traditional manufacturing approaches. Computer simulations are useful for connecting processing, structure, and performance for these materials, but validation data that span this full range is difficult to produce. This research is part of a broad effort by the Additive Manufacturing Benchmark Test Series to produce such datasets for laser powder bed fusion builds of nickel Alloy 718. Here, single laser tracks produced with variations in laser power, scan velocity, and laser diameter, and arrays of adjacent laser tracks on bare wrought Alloy 718 plates are examined using optical microscopy, electron backscatter diffraction, and energy dispersive spectroscopy.
Kidney transplantation in patients with ANCA-associated vasculitis is associated with a high incidence of post-transplant cancer
Authors: Perna Alessandro , Campise Mariarosaria , Alfieri Carlo Maria , Regalia Anna , Cresseri Donata , Gandolfo Maria Teresa , Castellano Giuseppe 
Published: June 2024

Abstract
Background
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare disease with limited data on outcomes after transplantation.

Methods
In this single-center retrospective cohort study, we describe the outcomes of kidney transplant patients with AAV transplanted at our institute from February 2006 to January 2022.

Results
We identified 9 patients among 1026 with a pre-transplant diagnosis of AAV; all patients had received previous treatment with cyclophosphamide. Maintenance immunosuppression after transplantation was tacrolimus-based in 89% of the patients. At the end of a mean follow-up of 132 ± 61.1 months after transplantation, only one case of extrarenal vasculitis relapse was observed. The relapse rate was 0.01 per patient per year, which is comparable to that reported in the literature. However, seven patients were diagnosed with cancer after a mean follow-up of 81.4 months after transplantation; six had skin cancer and three had renal cell carcinoma (RCC) of the native kidneys (cumulative incidence of 78%). One patient died from metastatic squamous cell carcinoma.

Conclusion
In this study, we found a noticeable decrease in disease relapse (1 relapse in the present cohort vs 7 relapses in 19 patients in the previous cohort) in kidney transplant patients with AAV compared with previous data from our group (December 1987–January 2006). Conversely, we found a high incidence of post-transplant cancer. This result could be attributed to reduced immunosurveillance due to immunosuppression therapy before and after transplantation. Therefore, constant cancer early diagnosis and prevention is mandatory during the post-transplant follow-up of AAV patients.

Graphical abstract
Beyond prevalence: significance and differential impact of echocardiographic abnormalities in dialysis patients
Authors: Tseng Chih-Hsueh , Hu Yi-An , Chen Yung-Tai , Yu Wen-Chung , Lin Chih-Ching , Li Szu-Yuan 
Published: June 2024

Abstract
Background
Echocardiography is commonly used to assess hydratation status and cardiac function in kidney failure patients, but the impact of structural or functional abnormalities on the prognosis of kidney failure patients was yet to be investigated. This study aimed to investigate the prevalence and clinical significance of echocardiographic abnormalities in kidney failure patients.

Methods
This study included 857 kidney failure patients who underwent echocardiography at dialysis initiation. Patients were followed up for a median of 4.2 years for the occurrence of major adverse cardiovascular events (MACE) and all-cause mortality.

Results
Among the 857 patients studied, 77% exhibited at least one echocardiographic abnormality. The most common abnormalities were left ventricular hypertrophy and left atrial enlargement, but they were not significantly correlated with poor outcomes. Instead, the primary predictors of both major adverse cardiovascular events and mortality in kidney failure patients were left ventricular systolic function, right ventricular systolic function, left ventricular volume index, and valvular abnormalities. Although diastolic dysfunction was linked to major adverse cardiovascular events, it was not associated with mortality. Furthermore, the study revealed that increased left ventricular volume index and left ventricular systolic dysfunction had a more significant impact on peritoneal dialysis (PD) patients than on hemodialysis (HD) patients.

Conclusion
This study provides insights into the echocardiographic abnormalities and their association with adverse outcomes in kidney failure patients, which can help clinicians optimize the management of patients and closely monitor possible high-risk populations.

Graphical abstract
Food patch selection by the largest European herbivore
Authors: Kowalczyk Rafał , Kamiński Tomasz , Borowik Tomasz 
Published: June 2024

AbstractThe scaling relationship between digestive system and body mass shapes foraging strategies in herbivores. The Jarman–Bell principle and the forage maturation hypothesis (FMH), two of the most important predictions formulated in herbivore foraging ecology, have been used to explain this relationship.We aimed to test these predictions for the largest European herbivore—the European bison-which is highly sexually dimorphic and recognised as a refugee species in non-optimal forest habitats. We conducted our study in the Białowieża Primeval Forest, where the European bison has been recognized as a refugee species. We estimated vegetation quality and biomass along the foraging paths of male and female European bison, and the vegetation biomass at random points in different habitats and months. We found no support for the Jarmann-Bell principle at the intraspecific level in European bison, as males and females foraged on patches of similar crude protein and fibre content. However, females selected for higher biomass. The quality of vegetation on the bison foraging patches showed a significant spatio-temporal variation. It increased from May to July and then gradually decreased. It also increased with the fertility and wetness of the habitats being the highest in wet forests. Mean biomass on European bison foraging patches (131.5 g/m2), was significantly lower than on random plots (210.5 g/m2), which supported the FMH. Our study suggests that in rich forest habitats, the abundant food resources available in summer may not constrain the metabolic rate/gut capacity ratio of either sex, potentially leading to dietary segregation. In contrast to open habitats, where vegetation maturation is less temporally variable, European bison in rich forest habitats may optimise patch selection and energy intake by tracking a habitat- and species-specific changes in the plant phenology. Understanding the relationship between European bison forage selection and forage nutritional constraints in forest habitats may be critical for conservation programmes, as European bison are better adapted to more open habitats and are recognised as refugee species in suboptimal forest habitats.
CLIMATE-RELATED DISCUSSIONS ON SOCIAL MEDIA: CRITICAL LESSONS FOR POLICYMAKERS
Authors: Mandal Anandadeep , Kaushal Akshay , Acharjee Animesh 
Published: June 2024

AbstractClimate change is a complex global issue that requires widespread understanding, support and collaboration for effective solutions. This research delves into the crucial role of communication in tackling climate change and reaching net-zero goals. Leveraging advanced machine learning techniques, we focus on 10 core climate change topics derived from social media conversations over time. This analysis underscores the importance of a holistic and interconnected approach, involving a diverse array of policies at local, national and global levels to combat climate change effectively and attain net-zero objectives. We offer key policy suggestions that can significantly contribute to this vital cause.
RNA sequencing screening and gene function analysis uncover G protein-coupled receptor 183 as a key mediator for methionine to stimulate milk synthesis in mouse mammary epithelial cells
Authors: Zhou Yuwen , Fan Sihua , Xu Ming , Zhang Minghui , Gao Xuejun 
Published: June 2024

AbstractMethionine (Met) can activate the mechanistic target of rapamycin (mTOR) to promote milk synthesis in mammary epithelial cells. However, it is largely unknown which G protein-coupled receptor can mediate the stimulation of Met on mTOR activation. In this study, we employed transcriptome sequencing to analyse which G protein-coupled receptors were associated with the role of Met and further used gene function study approaches to explore the role of G protein-coupled receptor 183 (GPR183) in Met stimulation on mTOR activation in HC11 cells. We identified nine G protein-coupled receptors including GPR183 whose expression levels were upregulated by Met treatment through RNA sequencing and subsequent quantitative real-time PCR analysis. Using GPR183 knockdown and overexpression technology, we demonstrate that GPR183 is a positive regulator of milk protein and fat synthesis and proliferation of HC11 cells. Met affected GPR183 expression in a dose-dependent manner, and GPR183 mediated the stimulation of Met (0·6 mM) on milk protein and fat synthesis, cell proliferation and mTOR phosphorylation and mRNA expression. The inhibition of phosphoinositide 3-kinase blocked the phosphorylation of mTOR and AKT stimulated by GPR183 activation. In summary, through RNA sequencing and gene function study, we uncover that GPR183 is a key mediator for Met to activate the phosphoinositide 3-kinase-mTOR signalling and milk synthesis in mouse mammary epithelial cells.
Impact of total parenteral nutrition v. exclusive enteral nutrition on postoperative adverse outcomes in patients with penetrating Crohn’s disease undergoing surgical resection: a retrospective cohort study
Authors: Sun Zhenya , Cao Lei , Chen Yusheng , Song Tianrun , Guo Zhen , Zhu Weiming , Li Yi 
Published: June 2024

AbstractAchieving optimal nutritional status in patients with penetrating Crohn’s disease is crucial in preparing for surgical resection. However, there is a dearth of literature comparing the efficacy of total parenteral nutrition (TPN) v. exclusive enteral nutrition (EEN) in optimising postoperative outcomes. Hence, we conducted a case-matched study to assess the impact of preoperative EEN v. TPN on the incidence of postoperative adverse outcomes, encompassing overall postoperative morbidity and stoma formation, among penetrating Crohn’s disease patients undergoing bowel surgery. From 1 December 2012 to 1 December 2021, a retrospective study was conducted at a tertiary centre to enrol consecutive patients with penetrating Crohn’s disease who underwent surgical resection. Propensity score matching was utilised to compare the incidence of postoperative adverse outcomes. Furthermore, univariate and multivariate logistic regression analyses were conducted to identify the risk factors associated with adverse outcomes. The study included 510 patients meeting the criteria. Among them, 101 patients in the TPN group showed significant improvements in laboratory indicators at the time of surgery compared with pre-optimisation levels. After matching, TPN increased the occurrence of postoperative adverse outcomes (92·2 % v. 64·1 %, P = 0·001) when compared with the EEN group. In the multivariate analysis, TPN showed a significantly higher OR for adverse outcomes than EEN (OR = 4·241; 95 % CI 1·567–11·478; P = 0·004). The study revealed that penetrating Crohn’s disease patients who were able to fulfil their nutritional requirements through EEN exhibited superior nutritional and surgical outcomes in comparison with those who received TPN.
The future of intergenerational transmission research: A prospective, three-generation approach
Authors: Howland Mariann A. , Glynn Laura M. 
Published: June 2024

AbstractDr. Dante Cicchetti’s pioneering theory and research on developmental psychopathology have been fundamental to the proliferation of research on intergenerational transmission over the last 40 years. In part due to this foundation, much has been learned about continuities and discontinuities in child maltreatment, attachment, parenting, and psychopathology across generations. Looking towards the future, we propose that this field stands to benefit from a prospective, three-generation approach. Specifically, following established prospective, longitudinal cohorts of children over their transition to parenting the next generation will afford the opportunity to investigate the developmental origins of intergenerational transmission. This approach also can address key outstanding questions and methodological limitations in the extant literature related to the confounding of retrospective and prospective measures; examination of mediators and moderators; and investigation of the roles of biology, environment, and their interplay. After considering these advantages, we offer several considerations and recommendations for future research, many of which are broadly applicable to the study of two or more generations. We hope that this discussion will inspire the leveraging of existing prospective cohorts to carry forward Dr. Cicchetti’s remarkable contributions, with the ultimate aim to inform the development of preventions and interventions that disrupt deleterious intergenerational cycles.