bluuebunny/crossref_metadata_2025_split huggingface dataset:
A survey of Quality Engineering–Management journals by bibliometric indicators
Authors: Franceschini Fiorenzo , Maisano Domenico 
Published: December 2009

AbstractThis paper analyses some of the most popular scientific journals in the Quality field from the point of view of three bibliometric indicators: the Hirsch (h) index for journals, the total number of citations and the h‐spectrum. In particular, h‐spectrum is a novel tool based on h, making it possible to (i) identify a reference profile of the typical authors of a journal; (ii) compare different journals; and (iii) provide a rough indication of their ‘bibliometric positioning’ in the scientific community. Results of this analysis can be helpful for guiding potential authors and members of the scientific community in the Quality Engineering/Management area. A large amount of empirical data are presented and discussed. Copyright © 2009 John Wiley & Sons, Ltd.
Enrichment and analysis of phosphopeptides under different experimental conditions using titanium dioxide affinity chromatography and mass spectrometry
Authors: Aryal Uma K. , Ross Andrew R. S. 
Published: December 2009

AbstractTitanium dioxide metal oxide affinity chromatography (TiO2‐MOAC) is widely regarded as being more selective than immobilized metal‐ion affinity chromatography (IMAC) for phosphopeptide enrichment. However, the widespread application of TiO2‐MOAC to biological samples is hampered by conflicting reports as to which experimental conditions are optimal. We have evaluated the performance of TiO2‐MOAC under a wide range of loading and elution conditions. Loading and stringent washing of peptides with strongly acidic solutions ensured highly selective enrichment for phosphopeptides, with minimal carryover of non‐phosphorylated peptides. Contrary to previous reports, the addition of glycolic acid to the loading solution was found to reduce specificity towards phosphopeptides. Base elution in ammonium hydroxide or ammonium phosphate provided optimal specificity and recovery of phosphorylated peptides. In contrast, elution with phosphoric acid gave incomplete recovery of phosphopeptides, whereas inclusion of 2,5‐dihydroxybenzoic acid in the eluant introduced a bias against the recovery of multiply phosphorylated peptides. TiO2‐MOAC was also found to be intolerant of many reagents commonly used as phosphatase inhibitors during protein purification. However, TiO2‐MOAC showed higher specificity than immobilized gallium (Ga3+), immobilized iron (Fe3+), or zirconium dioxide (ZrO2) affinity chromatography for phosphopeptide enrichment. Matrix‐assisted laser desorption/ionization mass spectrometry (MALDI‐MS) was more effective in detecting larger, multiply phosphorylated peptides than liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI‐MS/MS), which was more efficient for smaller, singly phosphorylated peptides. Copyright © 2009 Crown in the right of Canada. Published by John Wiley & Sons, Ltd.
Maximizing Functional Photoreceptor Differentiation From Adult Human Retinal Stem Cells
Authors: Inoue Tomoyuki , Coles Brenda L.K. , Dorval Kim , Bremner Rod , Bessho Yasumasa , Kageyama Ryoichiro , Hino Shinjiro , Matsuoka Masao , Craft Cheryl M. , McInnes Roderick R. , Tremblay Francois , Prusky Glen T. , van der Kooy Derek 
Published: December 2009

Abstract
Retinal stem cells (RSCs) are present in the ciliary margin of the adult human eye and can give rise to all retinal cell types. Here we show that modulation of retinal transcription factor gene expression in human RSCs greatly enriches photoreceptor progeny, and that strong enrichment was obtained with the combined transduction of OTX2 and CRX together with the modulation of CHX10. When these genetically modified human RSC progeny are transplanted into mouse eyes, their retinal integration and differentiation is superior to unmodified RSC progeny. Moreover, electrophysiologic and behavioral tests show that these transplanted cells promote functional recovery in transducin mutant mice. This study suggests that gene modulation in human RSCs may provide a source of photoreceptor cells for the treatment of photoreceptor disease.
Grounding and the influence of the total pressure losses in ducted wind turbines
Authors: Georgiou D. P. , Theodoropoulos N. G. 
Published: December 2009

AbstractDucted wind turbines are known to exceed the Betz limit for the power that may be extracted from free currents per unit cross‐sectional area of their rotors. The present study points to another advantage: the fact that the turbine rotor (and the associated subassemblies) need not be lifted up on the air and rotated to align with the wind. They can function just as effectively by installing them on the ground and sucking air inside it. The analysis evaluates the efficiency of a ducted wind turbine plant, exhausting into the wake of a bluff body, under both ideal and realistic component performance. The results indicate that there exists a strong need to develop diffusers with a very low loss coefficient (e.g. by employing suction or transpiration techniques). Under such conditions and by employing the above exhaust assist techniques, the ducted wind turbine concept may deliver efficiencies more than an order of magnitude larger than those of the conventional plants. Copyright © 2009 John Wiley & Sons, Ltd.
Most, but not all, yeast strains in the deletion library contain the [PIN+] prion
Authors: Manogaran Anita L. , Fajardo Viviana M. , Reid Robert J. D. , Rothstein Rodney , Liebman Susan W. 
Published: December 2009

AbstractThe yeast deletion library is a collection of over 5100 single gene deletions that has been widely used by the yeast community. The presence of a non‐Mendelian element, such as a prion, within this library could affect the outcome of many large‐scale genomic studies. We previously showed that the deletion library parent strain contained the [PIN+] prion. [PIN+] is the misfolded infectious prion form of the Rnq1 protein that displays distinct fluorescent foci in the presence of RNQ1–GFP and exists in different physical conformations, called variants. Here, we show that over 97% of the library deletion strains are [PIN+]. Of the 141 remaining strains that have completely (58) or partially (83) lost [PIN+], 139 deletions were able to efficiently maintain three different [PIN+] variants despite extensive growth and storage at 4 °C. One strain, cue2Δ, displayed an alteration in the RNQ1–GFP fluorescent shape, but the Rnq1p prion aggregate shows no biochemical differences from the wild‐type. Only strains containing a deletion of either HSP104 or RNQ1 are unable to maintain [PIN+], indicating that 5153 non‐essential genes are not required for [PIN+] propagation. Copyright © 2009 John Wiley & Sons, Ltd.
A novel kanamycin/G418 resistance marker for direct selection of transformants in Escherichia coli and different yeast species
Authors: Agaphonov Michael , Romanova Nina , Choi Eui‐Sung , Ter‐Avanesyan Michael 
Published: December 2009

AbstractWe have developed a set of cloning vectors possessing a modified Tn903 kanamycin resistance gene that enables the selection of both kanamycin‐resistant transformants in Escherichia coli and G418‐resistant transformants in the yeasts Saccharomyces cerevisiae, Hansenula polymorpha and Pichia pastoris. Expression of this gene in yeast is controlled by the H. polymorpha glyceraldehyde‐3‐phosphate dehydrogenase promoter, while expression in E. coli is governed by an upstream E. coli lacZ promoter. Applicability of the vectors for gene disruption in H. polymorpha and S. cerevisiae was demonstrated by inactivation of the HpMAL1 and URA3 genes, respectively. One of the vectors possesses a H. polymorpha ARS allowing plasmid maintenance in an episomal state. The small size of the vectors (2–2.5 kb) makes them convenient for routine DNA cloning. In addition, we report a novel approach for construction of gene disruption cassettes. Copyright © 2009 John Wiley & Sons, Ltd.
Hsp70/Hsp90 co‐chaperones are required for efficient Hsp104‐mediated elimination of the yeast [PSI+] prion but not for prion propagation
Authors: Moosavi Behrooz , Wongwigkarn Jintana , Tuite Mick F. 
Published: December 2009

AbstractThe continued propagation of the yeast [PSI+] prion requires the molecular chaperone Hsp104 yet in cells engineered to overexpress Hsp104; prion propagation is impaired leading to the rapid appearance of prion‐free [psi−] cells. The underlying mechanism of prion loss in such cells is unknown but is assumed to be due to the complete dissolution of the prion aggregates by the ATP‐dependent disaggregase activity of this chaperone. To further explore the mechanism, we have sought to identify cellular factors required for prion loss in such cells. Sti1p and Cpr7p are co‐chaperones that modulate the activity of Hsp70/Ssa and Hsp90 chaperones and bind to the C‐terminus of Hsp104. Neither Sti1p nor Cpr7p is necessary for prion propagation but we show that deletion of theSTI1andCPR7genes leads to a significant reduction in the generation of [psi−] cells by Hsp104 overexpression. Deletion of theSTI1andCPR7genes does not modify the elimination of [PSI+] by guanidine hydrochloride, which inhibits the ATPase activity of Hsp104 but does block elimination of [PSI+] by overexpression of either an ATPase‐defective mutant of Hsp104 (hsp104K218T/K620T) or a ‘trap’ mutant Hsp104 (hsp104E285Q/E687Q) that can bind its substrate but can not release it. These results provide support for the hypothesis that [PSI+] elimination by Hsp104 overexpression is not simply a consequence of complete dissolution of the prion aggregates but rather is through a mechanism distinct from the remodelling activity of Hsp104. Copyright © 2009 John Wiley & Sons, Ltd.
A Comparison of Carotid Surgery in Northern Europe and Northern Africa
Authors: Taha Ashraf G. , Vikatmaa Pirkka , Soinne Lauri , Thabet Bahgat A. , Lepäntalo Mauri 
Published: December 2009

AbstractBackgroundAlthough the indications for carotid endarterectomy (CEA) are clearly defined by major trials, CEA has not been properly implemented in many developing regions, including Northern Africa represented in this study by Upper Egypt. This study was designed to estimate the need for CEA in symptomatic patients with significant internal carotid artery stenosis in Upper Egypt. The estimated needs and actual provision of CEA in Upper Egypt were compared with those of Uusimaa (Finland) and Wessex (England) regions, representing Northern Europe.MethodsIncidence rates were derived from a community‐based door‐to‐door survey in Upper Egypt, Oxford Community Stroke Project, and epidemiological Finnish studies. The provision of CEA was derived from the local registry of Vascular Surgery Department, Assiut University Hospitals in Upper Egypt; HUSVASC data registry at Helsinki University Central Hospital, and the published data of the Wessex region. The estimated needs were calculated using previously published proportions of patients eligible for CEA.ResultsThe population at risk of cerebral ischemic events (≥65 years old) is 4% of the Egyptian population compared with 16% and 15% of the British and Finnish populations, respectively. The incidence of stroke and transient ischemic attack (TIA) is comparable in England and Finland but higher than the Egyptian rates (1.9‰ and 2.1‰ vs. 1.2‰ for stroke; 0.5‰ and 0.6‰ vs. 0.2‰ for TIA, respectively). The ratio of the actual provision of CEA to the estimated need in Wessex and Uusimaa is the same (0.5), whereas it is much lower (0.003) in Upper Egypt.ConclusionsDespite the low incidence of stroke and TIA, there is a huge unmet need for CEA in Upper Egypt. Yet, Wessex and Uusimaa also seemed to be at a suboptimal level compared with the estimated need. If CEA could be offered annually to those 1,650 patients with severe symptomatic ICA stenosis, 275 strokes could be prevented in Upper Egypt in 5‐year duration, provided that the operative morbidity and mortality rates are equal to those reported in the large, randomized, controlled trials.
Residual Skin Tags Following Procedure for Prolapse and Hemorrhoids: Differentiation from Recurrence
Authors: Gao Xian Hua , Fu Chuan Gang , Nabieu Paul Fallah‐wandalachi 
Published: December 2009

AbstractPurposeThe aim of this study was to compare the incidence of recurrence and residual skin tag after the procedure for prolapse and hemorrhoids (PPH) versus conventional hemorrhoidectomy (CH) in the Chinese‐ and English‐language literature to explore the definition of recurrence after PPH.MethodsRelated Chinese‐ and English‐language literature was collected by several methods. Meta‐analysis was used to compare the incidence of recurrence and residual skin tag of PPH versus CH.ResultsIn China, 13.94% of hemorrhoids had a skin tag after PPH. The mean recurrence rate after PPH was 3.23% (range 0.40–26.44%). Our meta‐analysis of PPH versus CH of the Chinese studies showed that PPH had a significantly lower recurrence rate—13 studies, odds ratio (OR) 0.27, 95% confidence interval (CI) 0.17–0.42, p < 0.00001—and a higher incidence of skin tags with no significance—6 studies, OR 3.42, 95% CI 0.49–24.04, p = 0.22. Our meta‐analysis of PPH versus CH among the English‐language studies showed that PPH had a significantly higher recurrence rate—17 studies, 636 patients in the PPH group vs. 625 patients in the CH group, OR 2.96, 95% CI 1.57–5.56, p = 0.0008—and a significantly higher incidence of residual skin tags—8 studies, 297 patients in the PPH group vs. 289 patients in the CH group, OR 1.88, 95% CI 1.15–3.05, p = 0.01. However, the recurrence of prolapse was stated to be ascertained by anorectal examination in only six studies; meta‐analysis of the six studies showed that PPH was not associated with a higher recurrence—six studies, 230 patients in the PPH group vs. 220 patients in the CH group; OR 1.87, 95% CI 0.70–5.00, p = 0.22.ConclusionsPPH is not associated with a higher recurrence rate but is associated with a higher incidence of skin tags compared with CH. The reported high recurrence rates are probably caused by improper inclusion of residual skin tags into the recurrence data. Surgeons should perform anorectal examinations to differentiate a residual skin tag from a recurrence.
Performance of a Computerized Protocol for Trauma Shock Resuscitation
Authors: Sucher Joseph F. , Moore Frederick A. , Sailors R. Matthew , Gonzalez Ernest A. , McKinley Bruce A. 
Published: December 2009

AbstractBackgroundA computerized protocol was developed and used to standardize bedside clinician decision making for resuscitation of shock due to severe trauma during the first day in the intensive care unit (ICU) at a metropolitan Level I trauma center. We report overall performance of a computerized protocol for resuscitation of shock due to severe trauma, incorporating two options for resuscitation monitoring and intervention intensity, according to: (1) duration of use and (2) acceptance of computerized protocol‐generated instructions.MethodsA computerized protocol operated by clinicians, using a personal computer (PC) at the bedside, was used to guide clinical decision making for resuscitation of patients meeting specific injury and shock criteria. The protocol generated instructions that could be accepted or declined. Clinician acceptance of the protocol instructions was stored by the PC software in a database for each patient. A rule‐based, data‐driven protocol was developed using literature evidence, expert opinion, and ongoing protocol performance analysis. Logic–flow diagrams were used to facilitate communication among multidisciplinary protocol development team members. The protocol was computerized using standard programming methods and implemented using cart‐mounted PCs with a touch screen and keyboard interfaces. Protocol progression began with patient demographic data and criteria entry, confirmation of hemodynamic monitor instrumentation, request for specific hemodynamic performance data, and instructions for specific interventions (or no intervention). Use and performance of the computerized protocol was recorded in a protocol execution database. The protocol was continuously maintained with new literature evidence and database performance analysis findings. Initially implemented in 2000, the computerized protocol was refined in 2004 with two options for resuscitation intensity: pulmonary artery catheter‐ and central venous pressure‐directed resuscitation.ResultsOver 2 years ending at August 2006, a total of 193 trauma patients (mean Injury Severity Score was 27, survival rate 89%) were resuscitated using the computerized protocol. Protocol duration was 4400 hours or 22.7 ± 0.4 hours per patient. The computerized protocol generated 3724 instructions (19 ± 1 per patient) that required a bedside clinician response. In all, 94% of these instructions were accepted by the bedside clinician users.ConclusionsA computerized protocol to guide decision making for trauma shock resuscitation in a Level 1 trauma center surgical ICU was developed and used as standard of care. During 2 years ending at August 2006, 94% of computer‐generated instructions for specific interventions or measurements of hemodynamic performance were accepted by bedside clinicians, indicating appropriate, useful design and reliance on the computerized protocol system.
Evaluation of the Adequacy of Lymph Node Dissection in Pylorus‐Preserving Gastrectomy for Early Gastric Cancer Using the Maruyama Index
Authors: Yoo Moon‐Won , Park Do Joong , Ahn Hye Seong , Jeong Sang‐Ho , Lee Hyuk‐Joon , Kim Woo Ho , Kim Hyung‐Ho , Lee Kuhn Uk , Yang Han‐Kwang 
Published: December 2009

AbstractBackgroundThe Maruyama computer program predicts the percentage likelihood of disease in lymph node stations left undissected by a surgeon, according to the age and sex of the patient and the gross type, size, location, depth of invasion, and histology of the tumor. The Maruyama index (MI) is defined as the sum of the predictions of the percentage likelihood of disease in undissected regional lymph node station (station 1–12). It has been shown that an MI < 5 is a strong predictor of survival and that the MI is an independent predictor of overall survival and relapse risk. We used the MI to evaluate the adequacy of lymph nodes dissection in pylorus‐preserving gastrectomy (PPG) for early gastric cancer (EGC) performed at Seoul National University Hospital.MethodsFrom March 2003 to September 2007, PPG was performed for patients with EGC of the middle third of the stomach when the distal resection margin was greater than 2 cm and preservation of 3 cm antral segment was possible. MIs and pathologic data such as TNM stage and the presence of metastatic lymph node for each station were reviewed.ResultsPPG were performed on 24 patients. The mean age of the patients was 55 years. The median tumor size was 2.1 cm. The median and mean MI were 0 and 0.8, respectively. There were 23 cases of T1N0M0 tumor and one case of T2N0M0 tumor postoperatively. There were no recurrences (mean follow‐up period: 27.2 months).ConclusionsThe MI indicates that lymph node dissection during PPG performed in these 24 patients was adequate.
Multimedia Abstract Generation of Intensive Care Data: The Automation of Clinical Processes Through AI Methodologies
Authors: Jordan Desmond , Rose Sydney E. 
Published: December 2009

AbstractMedical errors from communication failures are enormous during the perioperative period of cardiac surgical patients. As caregivers change shifts or surgical patients change location within the hospital, key information is lost or misconstrued. After a baseline cognitive study of information need and caregiver workflow, we implemented an advanced clinical decision support tool of intelligent agents, medical logic modules, and text generators called the “Inference Engine” to summarize individual patient’s raw medical data elements into procedural milestones, illness severity, and care therapies. The system generates two displays: 1) the continuum of care, multimedia abstract generation of intensive care data (MAGIC)—an expert system that would automatically generate a physician briefing of a cardiac patient’s operative course in a multimodal format; and 2) the isolated point in time, “Inference Engine”—a system that provides a real‐time, high‐level, summarized depiction of a patient’s clinical status. In our studies, system accuracy and efficacy was judged against clinician performance in the workplace. To test the automated physician briefing, “MAGIC,” the patient’s intraoperative course, was reviewed in the intensive care unit before patient arrival. It was then judged against the actual physician briefing and that given in a cohort of patients where the system was not used. To test the real‐time representation of the patient’s clinical status, system inferences were judged against clinician decisions. Changes in workflow and situational awareness were assessed by questionnaires and process evaluation. MAGIC provides 200% more information, twice the accuracy, and enhances situational awareness. This study demonstrates that the automation of clinical processes through AI methodologies yields positive results.
John Jones, M.D.: Pioneer, Patriot, and Founder of American Surgery
Authors: Griesemer Adam D. , Widmann Warren D. , Forde Kenneth A. , Hardy Mark A. 
Published: December 2009

AbstractJohn Jones was a pioneer of American Surgery. Born in Long Island, New York in 1729, he received his medical degree in France from the University of Rheims. He returned to the colonies and helped to establish the medical school that would later become Columbia University’s College of Physicians and Surgeons where he was appointed the first Professor of Surgery in the New World. He used his position to assert that surgeons trained in America should be familiar with all facets of medicine and not be mere technicians. Before the outbreak of the American Revolution, he wrote a surgical field manual, which was the first medical text published in America. A believer in the principles of the American Revolution, he would go on to count Benjamin Franklin and George Washington as his patients. Despite achieving many firsts in American medicine, his influence on surgical training is his most enduring legacy.
Residual Nodal Disease in Biopsy Proven N1/N2 Breast Cancer Following Neoadjuvant Systemic Therapy
Authors: Al Mushawah Fatema , Tan Marcus C. , Margenthaler Julie A. 
Published: December 2009

AbstractBackgroundThe purpose of this study was to determine the rate of complete pathologic response in axillary lymph nodes after neoadjuvant therapy and the clinicopathologic factors associated with a complete response.MethodsClinical, demographic, and pathologic data from all patients with breast cancer treated at our institution are prospectively recorded in a database. We reviewed this database from 2000 to 2007 and identified 90 patients who were node‐positive before neoadjuvant therapy based on image‐guided fine needle aspiration biopsy; all 90 patients underwent axillary lymph node dissection (ALND) after neoadjuvant therapy. Data were compared using chi‐square and Fisher’s exact test.ResultsOf 90 patients with breast cancer who were node‐positive before neoadjuvant therapy, 71 (79%) had positive nodal disease on final ALND pathology and 19 (21%) had a complete nodal pathologic response. Age, race, tumor grade, clinical T and N stage, and estrogen/progesterone receptor and Her‐2neu status were not predictive of a complete nodal response. The only factor predictive of a complete nodal response was the type of neoadjuvant therapy used; all 19 patients with a complete response received neoadjuvant chemotherapy and none received neoadjuvant endocrine therapy (P < 0.05).ConclusionsTwenty‐five percent of patients who underwent neoadjuvant chemotherapy had a complete pathologic response in the nodal basin, whereas no patient who underwent neoadjuvant endocrine therapy experienced a complete nodal response.SummaryTwenty‐five percent of patients who underwent neoadjuvant chemotherapy had a complete pathological response in the nodal specimen, whereas no patient who underwent neoadjuvant endocrine therapy experienced a complete nodal response.