bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of plate design on maintenance of anterior and posterior gaps and posterior tibial slope after cyclic loading in medial open‐wedge high tibial osteotomy: A biomechanical study using porcine's tibia
Authors: Nibe Yoshiya , Takahashi Tsuneari , Matsumura Tomohiro , Kubo Tatsuya , Takeshita Katsushi 
Published: June 2024

AbstractPurposeWe aimed to investigate whether a plate adapted to the anatomy of the proximal medial porcine's tibia would provide maintenance of the anterior gap (AG), posterior gap (PG) and posterior tibial slope (PTS).MethodsTwenty‐seven porcine tibias were biomechanically evaluated by performing MOWHTO and placing TOMOFIX (n = 9), AC plate (n = 9) and TriS (n = 9) anteromedially. Cyclic testing (800 N, 2000 cycles, 0.5 Hz) was performed to investigate the PTS over time for MOWHTO. The particular displacement calculated from the maximum to the minimum point with the load‐displacement curve along the mechanical axis during cyclic testing, the final AG and PG changes at the osteotomy site, the increased PTS calculated by subtracting AG from PG after 2000 cycles were compared among the three groups. The displacement was evaluated by repeated‐measures analysis of variance (ANOVA), and changes in AG and PG and increased PTS were evaluated by one‐way ANOVA. The sample size for α and β errors were <0.05 and <0.20, and the effect size was 0.64 for one‐way ANOVA and 0.49 for repeated‐measures ANOVA.ResultsThere were no significant differences in displacement among the groups. A significant difference was observed in the AG (p = 0.044) and PG (p = 0.0085) changes. There were no significant differences in increased PTS among the groups.ConclusionWhen anteromedially placed, the AC plate and TriS resulted in significant maintenance of AG and PG compared with that of TOMOFIX in MOWHTO after cyclic loading.Level of EvidenceLevel Ⅳ.
New edaravone analogs incorporated with N‐benzylthiazole moiety: Multistep chemical synthesis, in vitro cytotoxicity with pRIPK3 inhibitory activities, and molecular docking
Authors: Ahmed Abdullah A. , El‐All Mahmoud M. Abd , El‐Hallouty Salwa M. , Elshahid Zeinab A. , Eliwa Essam M. 
Published: June 2024

AbstractIn this research article, the chemical synthesis of new N‐phenylpyrazolone‐N‐benzylthiazole hybrids (3–6) via late‐stage thiazolation of the corresponding benzylthiosemicarbazone 2 was reported. The skeletal structural of the new molecules were validated by instrumental measurements (FT‐IR, NMR, and EI‐MS). In vitro cytotoxicity‐based cellular MTT bioassay shows that compound 3 that bears an N‐benzyl‐4‐thiazolone moiety is the most potent one toward the osteosarcoma cell line (Hos) with an IC50 value of 5.8 ± 0.1 μM, while compound 4a that contains a 5‐acetyl‐N‐benzylthiazole unit is the most robust one against the model lung carcinoma cell line (A549) with an IC50 value of 9.23 ± 0.01 μM. Also, 3 is roughly equipotent to 4b in its cytotoxicity activity against A549. In vitro enzymatic ELISA bioassay of A549 cells indicates that IC50 of 3 caused a decrease in the pRIPK3 kinase concentration (2.89 ± 0.005 pg/mL) as compared to DMSO‐treated cells (2.93 ± 0.010 pg/mL), while the pRIPK3 level incresed with 4b impact. As a result, 3 may be an effective inhibitor of pRIPK3 and hence necroptosis, proposing a novel therapeutic strategy for necroptosis‐related illnesses. In silico molecular docking shows that 3 interlocked and fitted well into the binding site of RIPK3 (PDB code: 7MX3) with a fitness value (−123.382 kcal/mol) lower than 4b and forms an important H‐bond with Lys50 like the marketed RIPK3 inhibitor GSK'843, validating the experimental results. Consequently, 3 is the most promising molecule that could be a lead candidate for further studies.
Where and what separates rural from urban hospital closures?
Authors: Turbow Sara D. , Lom Jennifer , Ali Mohammed K. 
Published: June 2024

AbstractDespite the recent closure of several high‐profile metropolitan hospitals, investigations into risk factors for metropolitan hospital closures have been limited. The goal of this study was to describe metropolitan hospitals that closed and compare them to metropolitan hospitals that remain open and micropolitan and rural hospitals that closed using American Hospital Association Annual Survey Data from 2010 to 2021. We independently verified hospitals reported as closed in the Annual Survey and examined the hospital characteristics associated with closure using bivariate statistics and logistic regression. We found that metropolitan hospitals that closed (n = 142) were more likely to be for‐profit (66.9% vs. 29.7%, p < .0001; adjusted odds ratio [AOR]: 3.05, 95% confidence interval [CI]: 1.93, 4.81) and to come from a state that did not expand Medicaid (45.1% vs. 29.4%, p < .0001; AOR: 1.66, 95% CI: 1.16, 2.38). Policies tailored to metropolitan hospitals should be developed to identify at‐risk hospitals and mitigate the effect of closures on patients, clinicians, and other stakeholders.
Recent advances in gas phase unfolding: Instrumentation and applications
Authors: Matney Rowan , Gadkari Varun V. 
Published: June 2024

AbstractBroader adoption of native mass spectrometry (MS) and ion mobility‐mass spectrometry (IM‐MS) has propelled the development of several techniques which take advantage of the selectivity, sensitivity, and speed of MS to make measurements of complex biological molecules in the gas phase. One such method, collision induced unfolding (CIU), has risen to prominence in recent years, due to its well documented capability to detect shifts in structural stability of biological molecules in response to external stimuli (e.g., mutations, stress, non‐covalent interactions, sample conditions etc.). This increase in reported CIU measurements is enabled partly due to advances in IM‐MS instrumentation by vendors, and also innovative method development by researchers. This perspective highlights a few of these advances and concludes with a look forward toward the future of the gas phase unfolding field.
Reasons for interruptions at work: Illuminating the perspective of the interrupter
Authors: Toebben Leon , Casper Anne , Wehrt Wilken , Sonnentag Sabine 
Published: June 2024

SummaryThis research sheds light on two crucial yet overlooked aspects of work interruptions: the perspective of employees who initiate interruptions and the reasons behind those interruptions. Building on earlier research on interruptions and theories on employee motivation, we identified six key reasons for interruptions that we integrated into a typology. This typology combined three interruption topics (performance, belongingness, and hedonic well‐being) and two interruption foci (benefitting the interrupter and benefitting the interruptee; i.e., self‐focused and other‐focused). We validated this typology using qualitative reports and a scale‐development approach, thereby creating the interruption‐for‐a‐reason scale (IFRS). We found that interruptions were typically initiated for good reasons and positively correlated with social exchange constructs. That is, initiating interruptions was linked to requesting social support and to performing prosocial behaviors to coworkers. Altogether, this research contributes to a more comprehensive understanding of interruptions by offering a new perspective on interruptions that addresses the complexities of this phenomenon. Illuminating the interrupters' perspective and the various reasons for interruptions is key to a more balanced examination of the positive and negative aspects of interruptions.
Safety of An Enhanced Recovery After Surgery Protocol After Head and Neck Free Tissue Transfer
Authors: Schuman Ari D. , Bindal Mohini , Amadio Grace , Turney Anne M. , Hernandez David J. , Sandulache Vlad C. , Liou N. Eddie , Wang Ray , Huang Andrew T. 
Published: June 2024

ObjectivesImplementing enhanced recovery after surgery (ERAS) protocols and decreasing length of stay (LOS) have become a priority for major surgeries, including microvascular free tissue transfer (MVFTT) reconstruction of the head and neck. We describe an ERAS protocol with the goal to further reduce length of stay beyond national medians.MethodsRetrospective chart review between August 2016 and February 2023, including all patients who underwent MVFTT after oral cavity, skull base, salivary gland, and cutaneous ablative surgery. An ERAS protocol was implemented in March 2020.ResultsA total of 383 patients were included. Approximately 59.8% underwent oral cavity MVFTT, 34.5% cutaneous and lateral skull base, and 5.8% maxillary and anterior skull base. A total of 209 (54.7%) patients had surgery prior to implementation of the ERAS protocol and 174 (45.3%) after. Median LOS decreased from 9 days (interquartile interval [IQR] 8–11) to 6 (IQR 5–7.5, p < 0.0001) following oral cavity MVFTT. For cutaneous and lateral skull base reconstruction, median LOS decreased from 6 days (IQR 5–8) to 3 (IQR 3–7, p < 0.0001). For anterior skull base and sinonasal MVFTT, median LOS decreased from 8 (IQR 7–9) to 5 days (IQR 4.5–7, p = 0.0005). Rate of discharge to skilled nursing or subacute rehabilitation facilities decreased (24% before ERAS, 9.2% after, p < 0.0001). Thirty‐day readmission rate was similar before and after implementation (10.5% vs. 10.3, p = 0.954). Discharge to facility was associated with readmission (OR 2.34, 95% CI 1.12–4.89, p = 0.024).Conclusion and RelevanceImplementation of the ERAS protocol was associated with decreased LOS. There was no increase in rate of readmission.Level of EvidenceNA Laryngoscope, 134:4527–4534, 2024
Utility of Ultrahigh‐Resolution Computed Tomography for Laryngeal Reconstructive Surgery
Authors: Kise Norimoto , Hirakawa Hitoshi , Aniya Soya , Ooshiro Taiyo , Kondo Shunsuke , Tomoda Atsushi , Oyakawa Yoshiki , Kiyuna Asanori , Suzuki Mikio 
Published: June 2024

ObjectiveUnilateral vocal fold paralysis (UVFP) presents as incomplete glottal closure and leads to breathy hoarseness. Various treatments, including laryngeal framework surgery (type 1 thyroplasty [TP1] and arytenoid adduction [AA]), have been devised to correct this condition. Ultrahigh‐resolution computed tomography (U‐HRCT) allows detailed three‐dimensional imaging of the larynx, which aids our understanding of vocal fold motion disorders. This study assessed whether U‐HRCT is beneficial for correct diagnosis and surgical planning.MethodsThe participants were 26 UVFP patients who underwent laryngeal framework surgery (TP1 and/or AA). U‐HRCT was used to measure the vocal fold volume (VFV) and level difference (LD). The need to combine AA with TP1 to obtain satisfactory surgical outcomes was evaluated by U‐HRCT and various voice function tests.ResultsVFV was smaller in paralyzed folds than in unaffected folds. LD correlated strongly with voice parameters and showed high intra‐rater and inter‐rater reliability. The surgical outcome of the laryngeal framework surgery performed was judged to be excellent for improving voice function. Comparison of LD between the TP1 group and TP1 + AA group indicated that LD is an excellent parameter to determine the need to combine AA with TP1.ConclusionThese findings underscore the value of preoperative U‐HRCT, especially LD, in surgical decision‐making and afford insights for optimal phonosurgery and individualized intervention. Patients with LD >1.0 mm may benefit from thyroplasty with AA.Level of Evidence3 (case–control study) Laryngoscope, 134:4667–4673, 2024
Efficacy and Safety of 577‐nm Yellow Laser in the Treatment of Pigmented Epidermal Lesions
Authors: Mohamed Essamelden M. , Abd Elaleem Hazem L. , Ahmed Mona A. H. , Rageh Mahmoud A. 
Published: June 2024

ABSTRACTObjectivesFreckles and lentigines are common pigmented problems which not only cause substantial cosmetic morbidity but also create psychosocial concern. The available modalities for the treatment of pigmented lesions are often unsatisfactory for patients, require a long treatment period, and often cause skin irritation. With the advent of lasers, safe and effective treatment options for epidermal pigmentation have become more varied for different Fitzpatrick skin types. We aimed to evaluate the efficacy and safety of 577‐nm yellow laser in the treatment of pigmented epidermal lesions.MethodsThis study was carried out on 50 patients presented with pigmented epidermal lesions (25 presented with freckles and 25 presented with lentigines). Each patient received four treatment sessions with a 577‐nm diode laser at 2‐week intervals.ResultsThere was significant improvement in freckles and lentigines, as 23 out of 50 patients showed marked improvement, 11 patients showed moderate improvement, 10 patients showed mild improvement, and only six patients had no changes. Moreover, 23 patients were very satisfied, 18 patients were satisfied, and nine patients were not satisfied. As regards the safety of the 577‐nm yellow laser, there was no significant adverse effect among patients except pain, erythema, and hyperpigmentation, which resolved within one month after treatment.ConclusionsThis study showed that the 577‐nm yellow laser is an effective, safe, and well‐tolerated device in the treatment of freckles and lentigines.
The self on display: The impact of self‐objectification on luxury consumption
Authors: Sun Hao , Guo Zhaoyang , Qian Hanjin 
Published: June 2024

AbstractSelf‐objectification, the tendency to perceive oneself predominantly through the lens of physical appearance, has been a focal point of study in psychology and mental health fields. Yet, its intersection with marketing and consumer behavior remains underexplored. This study endeavors to fill this gap, unveiling self‐objectification as a novel driver behind the consumption of appearance‐related luxury goods. Such a tendency is hypothesized to arise from the heightened self‐presentation motivation prevalent among those exhibiting self‐objectification. Through three empirical experiments, we validate this connection, emphasizing a strong association between self‐objectification tendencies and luxury consumption, especially for appearance‐related products, with self‐presentation motivation mediating this relationship. Theoretically, our study integrates self‐objectification into the marketing area, linking it to consumer behaviors and enriching the prevailing literature while indicating directions for future research. From a practical perspective, our results offer important insights for luxury brand management. Moreover, by clarifying the impact of self‐objectification on purchasing behaviors, we aim to promote more informed consumer decision‐making.
Release and Transport of Nanomaterials from Hydrogels Controlled by Temperature
Authors: Jobdeedamrong Arjaree , Crespy Daniel 
Published: June 2024

AbstractUnderstanding the transport of nanoparticles from and within hydrogels is a key issue for the design of nanocomposite hydrogels for drug delivery systems and tissue engineering. To investigate the translocation of nanocarriers from and within hydrogel networks triggered by changes of temperature, ultrasmall (8 nm) and small (80 nm) silica nanocapsules are embedded in temperature‐responsive hydrogels and non‐responsive hydrogels. The ultrasmall silica nanocapsules are released from temperature‐responsive hydrogels to water or transported to other hydrogels upon direct activation by heating or indirect activation by Joule heating; while, they are not released from non‐responsive hydrogel. Programmable transport of nanocarriers from and in hydrogels provides insights for the development of complex biomedical devices and soft robotics.
Comparison of genetic and epigenetic profiles of periodontitis according to the presence of type 2 diabetes
Authors: Kang Junho , Lee Hansong , Joo Ji‐Young , Song Jae‐Min , Kim Hyun‐Joo , Kim Yun Hak , Park Hae Ryoun 
Published: June 2024

AbstractType 2 diabetes mellitus (T2DM) and periodontitis (PD) have intricated connections as chronic inflammatory diseases. While the immune response is a key factor that accounts for their association, the underlying mechanisms remain unclear. To gain a deeper understanding of the connection, we conducted research using a multiomics approach. We generated whole genome and methylation profiling array data from the periodontium of PD patients with DM (PDDM) and without DM to confirm genetic and epigenetic changes. Independent bulk and single‐cell RNA sequencing data were employed to verify the expression levels of hypo‐methylated genes. We observed a gradual rise in C>T base substitutions and hypomethylation in PD and PDDM patients compared with healthy participants. Furthermore, specific genetic and epigenetic alterations were prominently associated with the Fc‐gamma receptor‐mediated phagocytosis pathway. The upregulation of these genes was confirmed in both the periodontal tissues of PD patients and the pancreatic tissues of T2DM patients. Through single‐cell RNA analysis of peripheral blood mononuclear cells, substantial upregulation of Fc‐gamma receptors and related genes was particularly identified in monocytes. Our findings suggest that targeting the Fc‐gamma signaling pathway in monocytes holds promise as a potential treatment strategy for managing systemic complications associated with diabetes.
Tyrosine kinase inhibitors in HER2‐positive metastatic breast cancer with trastuzumab emtansine resistance: insights from a multicenter retrospective real‐world study
Authors: Sun Chunxiao , Hua Yijia , Jin Nan , Wang Xiaojia , Huang Jian , Wu Xinyu , Zeng Tianyu , Yan Xueqi , Yang Fan , Liang Yan , Huang Xiang , Li Wei , Yin Yongmei 
Published: June 2024

AbstractThe use of trastuzumab emtansine (T‐DM1) has revealed significant efficacy in HER2‐positive metastatic breast cancer (MBC). However, optimal therapeutic strategies following T‐DM1 failure remain a subject of debate in clinical practice. In this multicenter, retrospective, real‐world study, we sought to examine the effectiveness and safety of tyrosine kinase inhibitors (TKIs) as a therapeutic strategy in HER2‐positive MBC who developed T‐DM1 resistance. Between September 2018 and December 2022, 66 patients were enrolled. The median progression‐free survival of TKIs‐based therapy was 10.1 months (95% CI, 4.7–15.6). Objective response rate and clinical benefit rate were 18.2 and 66.7%, respectively. TKIs‐based therapy demonstrated better effectiveness in patients who had previously derived benefit from T‐DM1 and featured acquired resistance to trastuzumab. The most common adverse events were diarrhea (36, 54.5%), hand‐foot syndrome (31, 47.0%), and leucopenia (30, 45.5%). In conclusion, TKIs‐based therapy showed promising effectiveness and safety in HER2‐positive MBC patients after T‐DM1 failure.
Individualized Structural Perturbations on Normative Brain Connectome Restrict Deep Brain Stimulation Outcomes in Parkinson's Disease
Authors: Wang Xuyang , Fu Shiyu , Yoo Kwangsun , Wang Xiaoyue , Gan Lin , Zou Ting , Gao Qing , Han Honghao , Yang Zhenzhe , Hu Xiaofei , Chen Huafu , Liu Dingyang , Li Rong 
Published: June 2024

AbstractBackgroundPatients with Parkinson's disease (PD) respond to deep brain stimulation (DBS) variably. However, how brain substrates restrict DBS outcomes remains unclear.ObjectiveIn this article, we aim to identify prognostic brain signatures for explaining the response variability.MethodsWe retrospectively investigated a cohort of patients with PD (n = 141) between 2017 and 2022, and defined DBS outcomes as the improvement ratio of clinical motor scores. We used a deviation index to quantify individual perturbations on a reference structural covariance network acquired with preoperative T1‐weighted magnetic resonance imaging. The neurobiological perturbations of patients were represented as z scored indices based on the chronological perturbations measured on a group of normal aging adults.ResultsAfter applying stringent statistical tests (z > 2.5) and correcting for false discoveries (P < 0.01), we found that accelerated deviations mainly affected the prefrontal cortex, motor strip, limbic system, and cerebellum in PD. Particularly, a negative network within the accelerated deviations, expressed as “more preoperative deviations, less postoperative improvements,” could predict DBS outcomes (mean absolute error = 0.09, R2 = 0.15). Moreover, a fusion of personal brain predictors and medical responses significantly improved traditional evaluations of DBS outcomes. Notably, the most important brain predictor, a pathway connecting the cognitive unit (prefrontal cortex) and motor control unit (cerebellum and motor strip), partially mediates DBS outcomes with the age at surgery.ConclusionsOur findings suggest that individual structural perturbations on the cognitive motor control circuit are critical for modulating DBS outcomes. Interventions toward the circuit have the potential for additional clinical improvements. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Reconstruction with free jejunal flap in dystrophic epidermolysis bullosa complicated with hypopharyngeal cancer: A case report
Authors: Matsumoto Daiki , Otani Naoya , Seike Shien , Kubo Tateki 
Published: June 2024

AbstractEpidermolysis bullosa (EB) encompasses a range of rare genetic dermatological conditions characterized by mucocutaneous fragility and a predisposition to blister formation, often triggered by minimal trauma. Blisters in the pharynx and esophagus are well‐documented, particularly in dystrophic EB (DEB). However, there have been few reports of mucocutaneous squamous cell carcinoma (SCC) in the head and neck region, for which surgery is usually avoided. This report presents the first case of free jejunal flap reconstruction after total pharyngolaryngoesophagectomy for hypopharyngeal cancer in a 57‐year‐old patient with DEB. The patient with a known diagnosis of DEB had a history of SCC of the left hand and esophageal dilatation for esophageal stricture. PET‐CT imaging during examination of systemic metastases associated with the left‐hand SCC revealed abnormal accumulation in the hypopharynx, which was confirmed as SCC by biopsy. Total pharyngolaryngoesophagectomy was performed, followed by reconstruction of the defect using a free jejunal flap. A segment of the jejunum, approximately 15 cm in length, was transplanted with multiple vascular pedicles. The patient made an uneventful recovery postoperatively and was able to continue oral intake 15 months later with no complications and no recurrence of SCC in the head and neck region. While cutaneous SCC is common in DEB, extracutaneous SCC is relatively rare. In most previous cases, non‐surgical approaches with radiotherapy and chemotherapy were chosen due to skin fragility and multimorbidity. In the present case, vascular fragility and mucosal damage of the intestinal tract were not observed, and routine vascular and enteric anastomoses could be performed, with an uneventful postoperative course. Our findings suggest that highly invasive surgery, including free tissue transplantation such as with a free jejunal flap, can be performed in patients with DEB.