bluuebunny/crossref_metadata_2025_split huggingface dataset:
Areca Cessation and Dentists in Harrow (North London)
Authors: Nathan Kathryn A 
Published: January 2010

Aim To assess dentists’ awareness and provision of areca cessation counselling to patients in general dental practices in Harrow (North London) in 2007. Methods In this cross-sectional study, questionnaires with specific questions and a space for free comments were sent to all 150 general dentists in the Primary Care Trust NHS Harrow area on 1st June 2007. The questionnaires had been piloted and the study was given ethical approval by Harrow Research Ethics Committee. Completed questionnaires were assessed to determine dentists’ provision of areca cessation counselling to dental patients. Free comments were assessed for content and meaning. Results A response rate of 57% (83/150 dentists) was obtained. Dentists were nearly twice as likely to neglect to provide patients with areca cessation counselling (32.5%) than to neglect to provide tobacco cessation counselling (16.9%). Dentists’ comments revealed a lack of awareness and the materials and support needed to counsel patients in areca cessation. Conclusions The majority of dentists who took part in this study require increased training, support and materials to facilitate awareness of areca nut use in the community and cessation counselling for patients.
A Study of Patient Attitudes towards Fasting Prior to Intravenous Sedation for Dental Treatment in a Dental Hospital Department
Authors: McKenna Gerald , Manton Sarah , Neilson Avril 
Published: January 2010

Introduction Intravenous sedation is the most commonly used method of sedation for the provision of adult dental care. However, disparity exists in pre-operative fasting times in use for patients throughout the United Kingdom. Aims The aims of the study were to obtain information on the effects of existing extended pre-operative fasting regimens, to canvas patient opinions on the fasting process, and to record their positive and negative experiences associated with it. Methods A prospective cross-sectional descriptive study using survey methodology was conducted of adult patients attending a dental hospital for operative treatment under intravenous sedation. Sixty-four questionnaires were distributed over a four-month period, beginning 2nd October 2007. Results The surveyed patient pool consisted of 38 females and 14 males with a mean age of 32.4 years. The response rate achieved was 81.2%. Seventy-one per cent of patients indicated that normally they consumed something for breakfast, the most common items being tea and toast. Fifty-one per cent of patients indicated that they would wish to eat the same as normal prior to their appointment and 59% wished to drink as normal. Only 19% of respondents reported that they did not wish to eat anything, with 8% preferring not to drink anything at all. Seventy-nine per cent of the patients reported that they had experienced at least one adverse symptom after fasting and 42% had experienced two or more such symptoms. In general, those patients with more experience of sedation found fasting less unpleasant than those attending for the first time ( P<0.05). In addition, one-quarter of all patients indicated that the fasting process had made them feel more nervous about their sedation appointment. Conclusions The extended fasting regimen prior to intravenous sedation appeared to affect patients’ wellbeing, as the majority reported adverse symptoms.
Habitat use and spatial organisation of relocated black rhinos in Namibia
Authors: Göttert Thomas , Schöne Joachim , Zinner Dietmar , Hodges John Keith , Böer Michael 
Published: January 2010

Abstract
In this study we systematically examined species-specific exploration behaviour and behavioural acclimatisation of a black rhino Diceros bicornis founder group post-translocation. The study was carried out in a fenced region, approximately 350 km2 in size and directly adjacent to Etosha National Park in Namibia. Rhinos were radio-tracked and movement data were complemented by detailed habitat descriptions at the centres of rhino activity with vegetation plot sampling. Rhinos used both geological formations of the study area: Otavi dolomite and Etosha calcrete substrate. The latter was dominated by Acacia spp. due to former land use for livestock farming. The size of total and seasonal home ranges and core areas, as well as home range establishment patterns and habitat use, are highly variable among individual rhinos. Home ranges of most individuals from our study are among the largest recorded for the species. We found age class specific patterns of home range establishment, typical mating and social behaviour, seasonal changes of home range and core area size, and clear shifts in spatial behaviour over time. The results provide our best estimate to date for the natural exploration behaviour and behavioural acclimatisation of black rhinos in a semi-arid savannah ecosystem.
Interpretation of Resistivity Piezocone Tests in a Contaminated Municipal Solid Waste Disposal Site
Authors: Mondelli Giulliana , Giacheti Heraldo Luiz , Howie John A. 
Published: January 2010

Abstract
A resistivity piezocone (RCPTU–resistivity cone penetration test with pore pressure measurement) and groundwater and soil samplers were used to detect contamination from a landfill for urban solid waste located in the state of São Paulo in southeastern Brazil. Background resistivity values were obtained in the laboratory using undisturbed soil samples. The strong influence of clay minerals common in tropical soils made it difficult to interpret the tests and to differentiate potentially contaminated zones from changes in soil type. A local correlation between fines content and the soil behavior index (Ic) of the various collected soils allowed the RCPTU tests to be interpreted to identify the contaminated regions of the aquifer. These results showed excellent repeatability and allowed for a detailed stratigraphic analysis of the highly heterogeneous profiles. Electrical resistivity measurements have proven to be an interesting resource to help detect contaminated soils, thus improving the quality and efficiency of geoenvironmental site investigations using integrated direct and indirect techniques. The interpretation of resistivity piezocone tests for the study site is not straightforward as it is in sedimentary sands since soil genesis affects soil behavior and soil and water sampling is required to support interpretation.
The Fission Yeast Rad32(Mre11)–Rad50–Nbs1 Complex Acts Both Upstream and Downstream of Checkpoint Signaling in the S-Phase DNA Damage Checkpoint
Authors: Willis Nicholas , Rhind Nicholas 
Published: January 2010

Abstract
The Mre11–Rad50–Nbs1 (MRN) heterotrimer plays various and complex roles in DNA damage repair and checkpoint signaling. Its role in activating Ataxia-Telangiectasia Mutated (ATM), the central checkpoint kinase in the metazoan double-strand break response, has been well studied. However, its function in the checkpoint independent of ATM activation, as well as functions that are completely checkpoint independent, are less well understood. In fission yeast, DNA damage checkpoint signaling requires Rad3, the homolog of the ATR (ATM and Rad3-related) kinase, not Tel1, the ATM homolog, allowing us to dissect MRN's ATM-independent S-phase DNA damage checkpoint roles from its role in ATM activation. We find that MRN is involved in Rad3 (ATR)-dependent checkpoint signaling in S phase, but not G2, suggesting that MRN is involved in ATR activation through its role in replication fork metabolism. In addition, we define a role for MRN in the S-phase DNA damage checkpoint-dependent slowing of replication that is independent of its role in checkpoint signaling. Genetic interactions between MRN and Rhp51, the fission yeast Rad51 homolog, lead us to suggest that MRN participates in checkpoint-dependent replication slowing through negative regulation of recombination.
Convergently Recruited Nuclear Transport Retrogenes Are Male Biased in Expression and Evolving Under Positive Selection in Drosophila
Authors: Tracy Charles , Río Javier , Motiwale Mansi , Christensen Shawn M , Betrán Esther 
Published: January 2010

Abstract
The analyses of gene duplications by retroposition have revealed an excess of male-biased duplicates generated from X chromosome to autosomes in flies and mammals. Investigating these genes is of primary importance in understanding sexual dimorphism and genome evolution. In a particular instance in Drosophila, X-linked nuclear transport genes (Ntf-2 and ran) have given rise to autosomal retroposed copies three independent times (along the lineages leading to Drosophila melanogaster, D. ananassae, and D. grimshawi). Here we explore in further detail the expression and the mode of evolution of these Drosophila Ntf-2- and ran-derived retrogenes. Five of the six retrogenes show male-biased expression. The ran-like gene of D. melanogaster and D. simulans has undergone recurrent positive selection. Similarly, in D. ananassae and D. atripex, the Ntf-2 and ran retrogenes show evidence of past positive selection. The data suggest that strong selection is acting on the origin and evolution of these retrogenes. Avoiding male meiotic X inactivation, increasing level of expression of X-linked genes in male testes, and/or sexual antagonism might explain the recurrent duplication of retrogenes from X to autosomes. Interestingly, the ran-like in D. yakuba has mostly pseudogenized alleles. Disablement of the ran-like gene in D. yakuba indicates turnover of these duplicates. We discuss the possibility that Dntf-2r and ran-like might be involved in genomic conflicts during spermatogenesis.
Patient-to-Nurse Ratios and Outcomes of Moderately Preterm Infants
Authors: Profit Jochen , Petersen Laura A. , McCormick Marie C. , Escobar Gabriel J. , Coleman-Phox Kim , Zheng Zheng , Pietz Kenneth , Zupancic John A. F. 
Published: January 2010

OBJECTIVE:
Moderately preterm infants (30–3467 weeks' gestational age) represent the largest population of NICU residents. Whether their clinical outcomes are associated with differences in NICU nurse-staffing arrangements has not been assessed. The objective of this study was to test the influence of patient-to-nurse ratios (PNRs) on outcomes of care provided to moderately preterm infants.

PATIENTS AND METHODS:
Using data from a prospective, multicenter, observational cohort study of 850 moderately preterm infants from 10 NICUs in California and Massachusetts, we tested for associations between PNR and several important clinical outcomes by using multivariate random-effects models. To correct for the influence of NICU size, we dichotomized the sample into those with an average daily census of &lt;20 or ≥20 infants.

RESULTS:
Overall, we found few clinically significant associations between PNR and clinical outcomes of care. Mean PNRs were higher in large compared with small NICUs (2.7 vs 2.1; P &lt; .001). In bivariate analyses, an increase in PNR was associated with a slightly higher daily weight gain (5 g/day), greater gestational age at discharge, any intraventricular hemorrhage, and severe retinopathy of prematurity. After controlling for case mix, NICU size, and site of care, an additional patient per nurse was associated with a decrease in daily weight gain by 24%. Other variables were no longer independently associated with PNR.

CONCLUSIONS:
In this population of moderately preterm infants, the PNR was associated with a decrease in daily weight gain, but was not associated with other measures of quality. In contrast with findings in the adult intensive care literature, measured clinical outcomes were similar across the range of nurse-staffing arrangements among participating NICUs. We conclude that the PNR is not useful for profiling hospitals' quality of care delivery to moderately preterm infants.
Improved Detection of Developmental Delays Among Young Children in Foster Care
Authors: Jee Sandra H. , Szilagyi Moira , Ovenshire Claire , Norton Amy , Conn Anne-Marie , Blumkin Aaron , Szilagyi Peter G. 
Published: January 2010

OBJECTIVE:Our goal was to determine if systematic use of a validated developmental screening instrument is feasible and improves the detection of developmental delay (DD) in a pediatric medical home for children in foster care.DESIGN AND METHODS:This study had a pre-post study design, following a practice intervention to screen all children in foster care for DD by using the Ages and Stages Questionnaire (ASQ). The baseline detection rate was determined by medical chart review for all children aged 4 to 61 months who were new to foster care (NFC) during a 2-year period. After implementation of systematic screening, caregivers of young children who were NFC or already in foster care (IFC) completed the ASQ at preventive health care visits. We assessed the feasibility of systematic screening (the percentage of ASQs completed among the NFC and IFC groups). We compared the detection of DD among the baseline NFC group and the screening-NFC group by using bivariate and multivariable logistic regression.RESULTS:Of 261 visits that occurred after initiation of screening, 251 (96%) visits had a completed ASQ form in the medical chart, demonstrating high feasibility. Among children who were NFC, the detection of DD was higher in the screening than baseline period for the entire population (58% vs 29%; P &lt; .001), for each age group (infants: 37% vs 14%; toddlers: 89% vs 42%; preschool: 82% vs 44%; all P ≤ .01), and for all developmental domains. On adjusted analyses, the detection of potential DD in toddler and preschool children was higher among the NFC screening group than the NFC baseline group.CONCLUSION:Systematic screening for DD using the ASQ was feasible and seemed to double the detection of DDs.
Relative Benefits of Population-Level Interventions Targeting Restraint-Use in Child Car Passengers
Authors: Du Wei , Finch Caroline F. , Hayen Andrew , Bilston Lynne , Brown Julie , Hatfield Julie 
Published: January 2010

OBJECTIVES:
Because public health resources for injury prevention are limited, methods for comparing competing strategies are needed. We aimed to estimate potential injury reductions for 4 population-level interventions that target restraint practices for child car passengers aged 0 to 12 years.

METHODS:
Population-attributable risk fraction (PARF) is a population-level estimate of excess risk from exposure to a risk factor. PARFs were calculated for each intervention scenario by using published age-specific mortality/injury relative-risk estimates; restraint practices among injured child car passengers from police-collected data; and observational data for correctness of restraint use in New South Wales, Australia. PARF reductions were estimated for population uptakes of 25%, 50%, and 75%.

RESULTS:
Assuming a 50% population uptake, (1) promoting age-appropriate restraint use could prevent additional fatalities (5.1%, infants; 3.4%, 1- to 6-year-olds) and nonfatal injuries (3.2%, infants; 16.2%, 1- to 6-year-olds) compared with promoting any restraint use; (2) further encouraging correct age-appropriate restraint use could also prevent additional fatalities (9.1%, infants; 14.3%, 1- to 6-year-olds) and nonfatal injuries (9.2%, infants; 10.7%, 1- to 6-year-olds); and (3) for children aged 7 to 12 years, promoting correct use of restraints could prevent an additional 3.4% fatalities and 3.1% nonfatal injuries compared with promoting any restraint use.

CONCLUSIONS:
Interventions that target child passenger-restraint practices offer population-level benefits in terms of reduction in fatalities and injuries. These tangible benefits call for action internationally, not only to promote restraint use but correct age-appropriate restraint use for child car passengers.
Injury-Prevention Practices as Depicted in G- and PG-Rated Movies, 2003–2007
Authors: Tongren Jon Eric , Sites Anne , Zwicker Katharyn , Pelletier Andrew 
Published: January 2010

OBJECTIVE:Our goal was to determine if the depiction of injury-prevention practices in children's movies is different from what was reported from 2 earlier studies, which showed infrequent depiction of characters practicing recommended safety behaviors.METHODS:The top-grossing 25 domestic G-rated (general audience) and PG-rated (parental guidance suggested) movies per year for 2003–2007 were included in this study. Movies or scenes were excluded if they were animated, not set in the present day, fantasy, documentary, or not in English. Injury-prevention practices involving motor vehicles, pedestrians, boaters, and bicyclists were recorded for characters with speaking roles.RESULTS:Sixty-seven (54%) of 125 movies met the inclusion criteria for this study. A total of 958 person-scenes were examined: 524 (55%) depicted children and 434 (45%) adults. Twenty-two person-scenes involved crashes or falls, resulting in 3 injuries and no deaths. Overall, 311 (56%) of 555 motor-vehicle passengers were belted; 73 (35%) of 211 pedestrians used crosswalks; 60 (75%) of 80 boaters wore personal flotation devices; and 8 (25%) of 32 bicyclists wore helmets. In comparison with previous studies, usage of safety belts, crosswalks, personal flotation devices, and bicycle helmets increased significantly.CONCLUSIONS:The entertainment industry has improved the depiction of selected safety practices in G- and PG-rated movies. However, approximately one half of scenes still depict unsafe practices, and the consequences of these behaviors are rarely shown. The industry should continue to improve how it depicts safety practices in children's movies. Parents should highlight the depiction of unsafe behaviors and educate children in following safe practices.
ATLANTIC DIP: The Impact of Obesity on Pregnancy Outcome in Glucose-Tolerant Women
Authors: Owens Lisa A. , O'Sullivan Eoin P. , Kirwan Breeda , Avalos Gloria , Gaffney Geraldine , Dunne Fidelma ,   for the ATLANTIC DIP Collaborators
Published: January 2010

OBJECTIVE
A prospective study of the impact of obesity on pregnancy outcome in glucose-tolerant women.

RESEARCH DESIGN AND METHODS
The Irish Atlantic Diabetes in Pregnancy network advocates universal screening for gestational diabetes. Women with normoglycemia and a recorded booking BMI were included. Maternal and infant outcomes correlated with booking BMI are reported.

RESULTS
A total of 2,329 women fulfilled the criteria. Caesarean deliveries increased in overweight (OW) (odds ratio 1.57 [95% CI 1.24–1.98]) and obese (OB) (2.65 [2.03–3.46]) women. Hypertensive disorders increased in OW (2.30 [1.55–3.40]) and OB (3.29 [2.14–5.05]) women. Reported miscarriages increased in OB (1.4 [1.11–1.77]) women. Mean birth weight was 3.46 kg in normal BMI (NBMI), 3.54 kg in OW, and 3.62 kg in OB (P &lt; 0.01) mothers. Macrosomia occurred in 15.5, 21.4, and 27.8% of babies of NBMI, OW, and OB mothers, respectively (P &lt; 0.01). Shoulder dystocia occur in 4% (&gt;4 kg) compared with 0.2% (&lt;4 kg) babies (P &lt; 0.01). Congenital malformation risk increased for OB (2.47 [1.09–5.60]) women.

CONCLUSIONS
OW and OB glucose-tolerant women have greater adverse pregnancy outcomes.
Incidence and Outcome of Operatively Treated Achilles Tendon Rupture in the Elderly
Authors: Čretnik Andrej , KošKir Roman , Kosanović Miloš 
Published: January 2010

Background: Very little has been published about Achilles tendon rupture in the elderly. Optimal therapy is controversial with conservative treatment generally recommended. The purpose of our study was to find the incidence and outcome of operatively treated Achilles tendon ruptures in the elderly. Materials and Methods: We determined the incidence of a closed complete Achilles tendon rupture in a period from 1991 to 2000 in two centers caring for 572,929 people with 108,668 people over 60 years of age. Results: In a 10-year period there were 434 ruptures, all of which were treated operatively: 146 in an open fashion and 288 percutaneously. The average incidence was 7.6 ruptures per 100,000 people. The average age of patients was 38.7 years, with a male-to-female ratio of 16.7:1. There were 14 ruptures in 13 patients older than 60 years, with the incidence of 1.28 ruptures per 100,000 people. Seven of the ruptures were operated on in an open way under spinal anesthesia and seven percutaneously under local anesthesia. The average age of the patients was 67.9 years, with a male-to-female ratio of 1.6:1 and the mean ASA score 1.64. There were no major complications in either group. One patient in the percutaneous group had transient sural nerve injury and one patient in the open group had a superficial infection. All of the patients returned to their previous activities, four of them with some limitations. The average AOFAS score was 93.1 points. Conclusion: Achilles tendon rupture in the elderly is a rare injury. Operative treatment can yield a successful outcome. Level of Evidence: III, Retrospective Comparative Study
Gastrocnemius Recession to Treat Isolated Foot Pain
Authors: Maskill John D. , Bohay Donald R. , Anderson John G. 
Published: January 2010

Background: Gastrocnemius recession is performed to correct an isolated gastrocnemius equinus contracture of the ankle that may accompany foot and ankle pathology in the adult. It has been proposed that this equinus deformity leads to excessive strain throughout the foot, thus causing pain. This can manifest itself in the form of plantar fasciitis, metatarsalgia, posterior tibial tendon insufficiency, osteoarthritis, and foot ulcers. The purpose of this retrospective study was to review the efficacy of the gastrocnemius recession in providing pain relief for patients who have foot pain without structural abnormality who have failed conservative treatment and have an isolated gastrocnemius contracture. Materials and Methods: Twenty-nine patients (34 feet) who had chronic foot pain without any structural abnormality other than an isolated gastrocnemius contracture underwent a gastrocnemius recession and were available for follow up at an average of 19.5 (range, 7 to 44) months. The outcome measurements were related to pain relief (Visual Analog Scale) and patient satisfaction. Results: Preoperatively the average pain score was 8/10 which improved postoperatively to 2/10. Twenty-seven patients (93.1%) said they would recommend this procedure for isolated foot pain to a friend. Twenty-seven patients (93.1%) said they were satisfied with the results of the procedure. Twenty-three of 25 patients (92%) who had a unilateral procedure stated they would have the contralateral leg done if needed. Conclusion: Gastrocnemius recession was found to be an effective procedure when used to relieve recalcitrant foot pain in those patients with an isolated gastrocnemius contracture without deformity. Level of Evidence: IV, Retrospective Case Series