bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mid‐term outcomes of carotid artery stenting in patients with angiographic string sign
Authors: Spacek Miloslav , Martinkovicova Lucie , Zimolova Petra , Veselka Josef 
Published: May 2011

AbstractObjectives: To report on early and mid‐term outcomes of carotid artery stenting (CAS) in patients with angiographic string sign (SS). Background: Little is known about the prognosis of patients with carotid SS treated by CAS. Methods: We retrospectively evaluated early and mid‐term outcomes, together with ultrasound findings, in patients with SS treated by CAS at our institution. Results: Of 308 CAS procedures, SS was diagnosed in 6.2% (19 patients, 58% symptomatic). Carotid stent implantation was successful in 18 patients (success rate 95%). There were no peri‐procedural adverse events. One patient suffered from a transient ischemic attack during hospitalization and died of pneumonia. All remaining patients completed a 30‐day follow‐up, and no complications were reported (asymptomatic restenosis was diagnosed in 1 patient and successfully redilated). Six patients died of causes unrelated to CAS (pneumonia, decompensated heart failure, and contralateral stroke) before completing a 6‐month follow‐up. However, these patients presented with more pronounced, unfavorable clinical and angiographic characteristics compared to the rest of the patients. Conclusions: We suggest that CAS might be performed with acceptable procedural risk in patients presenting with SS, which is unsuitable for surgery. However, patients' clinical and angiographic characteristics must be carefully evaluated when considering interventional therapy, regardless of the favorable procedural outcomes. © 2011 Wiley Periodicals, Inc.
Hybrid peratrial double device closure of a patent foramen ovale and sinus venosus defect in an infant with vein of galen malformation
Authors: Delaney Jeffrey W. , Thorell William E. , Hammel James M. 
Published: May 2011

AbstractVein of Galen aneurysmal malformation is the most common cerebral arteriovenous malformation in children. Neurointerventional embolization has improved outcomes with this lesion. An association with cardiac defects has been recognized and can increase the risk of systemic embolic events during treatment. Cardiopulmonary bypass (CPB) to correct the cardiac defect before repair of the malformation may be associated with compromised cerebral perfusion and possible neurologic injury. We describe a successful hybrid peratrial closure of two intracardiac shunts (a patent foramen ovale and a sinus venosus ASD) before neurointervention, avoiding CPB, and eliminating the intracardiac embolic risk during treatment of the vein of Galen malformation. © 2011 Wiley Periodicals, Inc.
Incidence and treatment of local stenosis or occlusion at the vascular access site leading to limb ischemia and new‐onset intermittent claudication after percutaneous interventions: Implications of Vascular Closure Devices
Authors: Klocker Josef , Gratl Alexandra , Chemelli Andreas , Moes Nicolas , Goebel Goerg , Pachinger Otmar , Jaschke Werner , Fraedrich Gustav 
Published: May 2011

AbstractObjective: Vascular access site complications (ASCs) are an ongoing hazard of percutaneous interventions (PI). We analyzed incidence, indication, and results of operative repair of access site complications leading to acute limb ischemia (ALI) or new‐onset severe claudication (CI) in our institution during an 8‐year period. Methods: Retrospective analysis: demographic parameters, details of coronary or vascular intervention, use of a vascular closure device (VCD), clinical presentation, diagnosis and therapy. Endpoints: perioperative outcome (death, limb loss, and need for re‐operation/intervention) and length of hospital stay. For comparison of annual operation rates, patients were grouped by the years 2001 to 2004 (no use of VCD) and 2005 to 2008 (selective use of a VCD; in all cases: Angio‐Seal), and Chi‐Square‐test was applied. Results: Fifty‐one patients (19 female; median age: 64.5 years) underwent repair of arterial ASCs causing ALI (n = 32) or new‐onset severe CI (n = 19) after 58,453 catheter interventions (overall rate: 0.087%; ALI: 0.055%; CI: 0.032%). Corresponding with more widespread VCD use, the annual number of ALI and new onset CI increased significantly (P < 0.001). Perioperative outcome: 30 day mortality was 4%. No limb loss occurred. Re‐operations were indicated in 10 patients (20%) for: hematoma (n = 5), local infection (n = 3), revision of fasciotomy (n = 1), and repeated thrombectomy (n = 1). Median length of postoperative hospital stay: 7 days (range: 1–28). Conclusion: ALI and new‐onset severe CI due to access site complications after PI are rare, however, they are potentially threatening life and limb. The use of VCDs results in an overall increase of ischemic complications. © 2011 Wiley Periodicals, Inc.
Idiopathic mediastinal fibrosis with involvement of the pulmonary vessels and left main coronary artery
Authors: Chang Shu‐Hsuan , Shih Chia‐Wen , Lei Meng‐Huan 
Published: May 2011

AbstractIdiopathic mediastinal fibrosis (IMF) is an uncommon clinical condition and the manifestations of this disease vary from a relatively benign disorder with minor symptoms to severe pulmonary vascular occlusion leading to mortality, commonly presenting a diagnostic and therapeutic challenge. Here, we present the case of a Taiwanese woman with obstruction of the left pulmonary veins and artery and stenosis of the left main coronary artery (LMCA) resulting from IMF. To our knowledge, this is the first reported case of IMF successfully treated with percutaneous balloon angioplasty with stent placement for the LMCA stenosis. © 2011 Wiley Periodicals, Inc.
A randomized trial of intravenous N‐acetylcysteine to prevent contrast induced nephropathy in acute coronary syndromes
Authors: Jaffery Zehra , Verma Anil , White Christopher J. , Grant Arthur G. , Collins Tyrone J. , Grise Mark A. , Jenkins James S. , McMullan Paul W. , Patel Rajan A. , Reilly John P. , Thornton Stanley N. , Ramee Stephen R. 
Published: May 2011

AbstractBackground: Pharmacokinetic data suggests that the intravenous form of n‐acetylcysteine (NAC) may be more effective than the oral formulation in preventing contrast induced nephropathy (CIN). NAC owing to its anti‐oxidant properties might be beneficial for patients with acute coronary syndromes (ACS) who are at increased risk for CIN. The aim of this prospective randomized, single‐center, double‐blind, placebo controlled trial (NCT00939913) was to assess the effect of high‐dose intravenous NAC on CIN in ACS patients undergoing coronary angiography and/or percutaneous coronary intervention (PCI). Methods: We randomized 398 ACS patients scheduled for diagnostic angiography ± PCI to an intravenous regimen of high‐dose NAC (1,200 mg bolus followed by 200 mg/hr for 24 hr; n = 206) or placebo (n = 192). The primary end‐point was incidence of CIN defined as an increase in serum creatinine concentration ≥25% above the baseline level within 72 hr of the administration of intravenous contrast. Results: There was no difference found for the primary end point with CIN in 16% of the NAC group and in 13% of the placebo group (p = 0.40). Change in serum cystatin‐C, a sensitive marker for renal function, was 0.046 ± 0.204 in the NAC group and 0.002 ± 0.260 in the control group (p = 0.07). Conclusion: In ACS patients undergoing angiography ± PCI, high‐dose intravenous NAC failed to reduce the incidence of CIN. © 2011 Wiley Periodicals, Inc.
Transcatheter closure of a mechanical perivalvular leak using real‐time three‐dimensional transesophageal echocardiography guidance
Authors: Siddiqi Nauman , Seto Arnold , Patel Pranav M. 
Published: May 2011

AbstractA 47‐year‐old female with symptomatic mitral stenosis from a prior undersized mitral annuloplasty ring underwent mitral valve replacement with a mechanical valve. Later, she developed heart failure from a severe paravalvular leak (PVL). Because of the excessive mortality risks from a possible third open heart procedure, the patient was instead referred for transcatheter PVL closure. Standard fluoroscopy, invasive hemodynamics, and two‐dimensional (2D) and three‐dimensional (3D) transesophageal echocardiography (TEE) imaging were performed during device placement with excellent image quality. The case highlights the unique benefit of 3D TEE imaging for preprocedure sizing, guidance of device deployment intraprocedure, and confirmation of PVL closure. © 2011 Wiley‐Liss, Inc.
Pathway‐Dependent Self‐Assembly of Perylene Diimide/Peptide Conjugates in Aqueous Medium
Authors: Tidhar Yaron , Weissman Haim , Wolf Sharon G. , Gulino Antonino , Rybtchinski Boris 
Published: May 2011

AbstractMost molecular self‐assembly strategies involve equilibrium systems, leading to a single thermodynamic product as a result of weak, reversible non‐covalent interactions. Yet, strong non‐covalent interactions may result in non‐equilibrium self‐assembly, in which structural diversity is achieved by forming several kinetic products based on a single covalent building block. We demonstrate that well‐defined amphiphilic molecular systems based on perylene diimide/peptide conjugates exhibit kinetically controlled self‐assembly in aqueous medium, enabling pathway‐dependent assembly sequences, in which different organic nanostructures are evolved in a stepwise manner. The self‐assembly process was characterized using UV/Vis circular dichroism (CD) spectroscopy, and cryogenic transmission electron microscopy (cryo‐TEM). Our findings show that pathway‐controlled self‐assembly may significantly broaden the methodology of non‐covalent synthesis.
Mechanistic Insights into Photochromic Behavior of a Ruthenium(II)–Pterin Complex
Authors: Ishizuka Tomoya , Sawaki Takuya , Miyazaki Soushi , Kawano Masaki , Shiota Yoshihito , Yoshizawa Kazunari , Fukuzumi Shunichi , Kojima Takahiko 
Published: May 2011

AbstractThe pterin‐coordinated ruthenium complex, [RuII(dmdmp)(tpa)]+ (1) (Hdmdmp=N,N‐dimethyl‐6,7‐dimethylpterin, tpa=tris(2‐pyridylmethyl)amine), undergoes photochromic isomerization efficiently. The isomeric complex (2) was fully characterized to reveal an apparent 180° pseudorotation of the pterin ligand. Photoirradiation to the solution of 1 in acetone with incident light at 460 nm resulted in dissociation of one pyridylmethyl arm of the tpa ligand from the RuII center to give an intermediate complex, [Ru(dmdmp)(tpa)(acetone)]2+ (I), accompanied by structural change and the coordination of a solvent molecule to occupy the vacant site. The quantum yield (ϕ) of this photoreaction was determined to be 0.87 %. The subsequent thermal process from intermediate I affords an isomeric complex 2, as a result of the rotation of the dmdmp2− ligand and the recoordination of the pyridyl group through structural change. The thermal process obeyed first‐order kinetics, and the rate constant at 298 K was determined to be 5.83×10−5 s−1. The activation parameters were determined to be ΔH≠=81.8 kJ mol−1 and ΔS≠=−49.8 J mol−1 K−1. The negative ΔS≠ value indicates that this reaction involves a seven‐coordinate complex in the transition state (i.e., an interchange associative mechanism). The most unique point of this reaction is that the recoordination of the photodissociated pyridylmethyl group occurs only from the direction to give isomer 2, without going back to starting complex 1, and thus the reaction proceeds with 100 % conversion efficiency. Upon heating a solution of 2 in acetonitrile, isomer 2 turned back into starting complex 1. The backward reaction is highly dependent on the solvent: isomer 2 is quite stable and hard to return to 1 in acetone; however, 2 was converted to 1 smoothly by heating in acetonitrile. The activation parameters for the first‐order process in acetonitrile were determined to be ΔH≠=59.2 kJ mol−1 and ΔS≠=−147.4 kJ mol−1 K−1. The largely negative ΔS≠ value suggests the involvement of a seven‐coordinate species with the strongly coordinated acetonitrile molecule in the transition state. Thus, the strength of the coordination of the solvent molecule to the RuII center is a determinant factor in the photoisomerization of the RuII–pterin complex.
Silica Nanocapsules of Fluorescent Conjugated Polymers and Superparamagnetic Nanocrystals for Dual‐Mode Cellular Imaging
Authors: Tan Happy , Wang Miao , Yang Chang‐Tong , Pant Shilpa , Bhakoo Kishore Kumar , Wong Siew Yee , Chen Zhi‐Kuan , Li Xu , Wang John 
Published: May 2011

AbstractWe describe here a facile and benign synthetic strategy to integrate the fluorescent behavior of conjugated polymers and superparamagnetic properties of iron oxide nanocrystals into silica nanocapsules, forming a new type of bifunctional magnetic fluorescent silica nanocapsule (BMFSN). The resultant BMFSNs are uniform, colloidally stable in aqueous medium, and exhibit the desired dual functionality of fluorescence and superparamagnetism in a single entity. Four conjugated polymers with different emissions were used to demonstrate the versatility of employing this class of fluorescent materials for the preparation of BMFSNs. The applicability of BMFSNs in cellular imaging was studied by incubating them with human liver cancer cells, the result of which demonstrated that the cells could be visualized by dual‐mode fluorescence and magnetic resonance imaging. Furthermore, the superparamagnetic behavior of the BMFSNs was exploited for in vitro magnetic‐guided delivery of the nanocapsules into the cancer cells, thereby highlighting their potential for targeting biomedical applications.
Proton‐Fueled DNA‐Duplex‐Based Stimuli‐Responsive Reversible Assembly of Single‐Walled Carbon Nanotubes
Authors: Zhao Chao , Qu Konggang , Ren Jinsong , Qu Xiaogang 
Published: May 2011

AbstractSingle‐walled carbon nanotubes (SWNTs) have received much attention in nanotechnology because of their potential applications in molecular electronics, field‐emission devices, biomedical engineering, and biosensors. Carbon nanotubes as gene and drug delivery vectors or as “building blocks” in nano‐/microelectronic devices has been successfully explored. However, since SWNTs lack chemical recognition, SWNT‐based electronic devices and sensors are strictly related to the development of a bottom‐up self‐assembly technique. Here we present an example of using DNA duplex‐based protons (H+) as a fuel to control reversible assembly of SWNTs without generation of waste duplex products that poison DNA‐based systems.
A data‐operation model based on partial vector space for batch processing in workflow
Authors: Liu Jianxun , Wen Yiping , Li Ting , Zhang Xuyun 
Published: May 2011

AbstractBatch processing in workflow schedules activity instances in multiple workflow cases of the same workflow type to run as a group. It can optimize business processes execution dynamically. To achieve this goal, it is necessary to define a dataflow operation language to group and ungroup the data in multiple cases of a workflow. Though our previous work has preliminarily investigated the model and its implementation, there is still lack of a formally defined model. In this paper, we first propose a method that is based on a partial vector space to model the dataflow in multiple workflow cases. Based on this model, the data operation primitives for batch processing are specified and defined formally. Since most WfMSs (Workflow Management Systems) use RDBMS (relational database management system) to store their data currently, an SQL (Structured Query Language)‐like implementation language, namely DBOL (Data Batch Operation Language), is proposed. Evaluation experiments have also been done to show its performance. Copyright © 2011 John Wiley & Sons, Ltd.
Flexible and efficient profiling with aspect‐oriented programming
Authors: Binder Walter , Ansaloni Danilo , Villazón Alex , Moret Philippe 
Published: May 2011

AbstractMany profilers for virtual execution environments, such as the Java virtual machine (JVM), are implemented with low‐level bytecode instrumentation techniques, which is tedious, error‐prone, and complicates maintenance and extension of the tools. In order to reduce the development time and cost, we promote building profilers for the JVM using high‐level aspect‐oriented programming (AOP). We show that the use of aspects yields concise profilers that are easy to develop, extend, and maintain, because low‐level instrumentation details are hidden from the tool developer. In order to build efficient profilers, we introduce inter‐advice communication, an extension to common AOP languages that enables efficient data passing between advices that are woven into the same method using local variables. We illustrate our approach with two case studies. First, we show that an existing, instrumentation‐based tool for listener latency profiling can be easily recast as an aspect. Second, we present an aspect for comprehensive calling context profiling. In order to reduce profiling overhead, our aspect parallelizes application execution and profile creation, resulting in a speedup of 110% on a machine with more than two cores, compared with
a primitive, non‐parallel approach. Copyright © 2011 John Wiley & Sons, Ltd.
Corporate Social Reporting in European Banks: The Effects on a Firm's Market Value
Authors: Carnevale Concetta , Mazzuca Maria , Venturini Sergio 
Published: May 2011

ABSTRACTDespite the increasing level of interest in CSR issues, it is not yet clear what real value the market assigns to social reporting. By applying the value relevance analysis to a sample of 130 European‐listed banks, the present work proposes a key to understanding the relationship between social reporting and the value that the market attributes to banks that publicize their commitment to CSR through social reporting. The analysis for the entire sample does not provide evidence that investors attribute value relevance to social reporting (i.e. there is not a significant correlation between the publication of a social report and the stock price). Cross‐country analysis shows that in some countries the social report is value‐relevant, and positively affects the stock price; in others it remains value‐relevant but negatively affects the stock price. Our findings could have several implications for banks, investors, and policymakers. Copyright © 2011 John Wiley & Sons, Ltd and ERP Environment.
Expression and rapid experience‐dependent regulation of type‐A GABAergic receptors in the songbird auditory forebrain
Authors: Jeong Jin Kwon , Terleph Thomas A. , Burrows Kaiping , Tremere Liisa A. , Pinaud Raphael 
Published: May 2011

AbstractGABAergic transmission influences sensory processing and experience‐dependent plasticity in the adult brain. Little is known about the functional organization of inhibitory circuits in the auditory forebrain of songbirds, a robust model extensively used in the study of central auditory processing of behaviorally relevant communication signals. In particular, no information is currently available on the expression and organization of GABAA receptor‐expressing neurons. Here, we studied the distribution and regulation of GABAA receptors in the songbird auditory forebrain, with a specific focus on α5, a subunit implicated in tonic inhibition and sensory learning. We obtained a zebra finch cDNA that encodes the α5‐subunit (GABRA5) and carried out a detailed analysis of its expression via in situ hybridization. GABRA5 was highly expressed in the caudomedial nidopallium (NCM), caudomedial mesopallium, and field L2. Using double fluorescence in situ hybridization, we demonstrate that a large fraction of GABRA5‐expressing neurons is engaged by auditory experience, as revealed by the song‐induced expression of the activity‐dependent gene zenk. Remarkably, we also found that α5 expression is rapidly regulated by sensory stimulation: 30 min of conspecific song playbacks significantly increase the number of GABRA5‐expressing neurons in NCM, but not in other auditory areas. This effect is selective for α5, but not γ2 transcripts. Our results suggest that α5‐containing GABAA receptors likely play a key role in central auditory processing and may contribute to the experience‐dependent plasticity underlying auditory learning. © 2011 Wiley Periodicals, Inc. Develop Neurobiol 71: 803–817, 2011
Amphetamine induced dopamine release increases anxiety in individuals recovered from anorexia nervosa
Authors: Bailer Ursula F. , Narendran Rajesh , Frankle W. Gordon , Himes Michael L. , Duvvuri Vikas , Mathis Chester A. , Kaye Walter H. 
Published: May 2011

AbstractObjective:Genetic, pharmacologic, and physiological data suggest that individuals with anorexia nervosa (AN) have altered striatal dopamine (DA) function.Method:We used an amphetamine challenge and positron emission tomography [11C]raclopride paradigm to explore DA striatal transmission in 10 recovered (REC) AN compared with 9 control women (CW).Results:REC AN and CW were similar for baseline, postamphetamine [11C]raclopride binding potential (BPND) and change (Δ) in BPND for all regions. In CW, ventral striatum Δ BPND was associated with euphoria (r = −0.76; p = 0.03), which was not found for REC AN. Instead, REC AN showed a significant relationship between anxiety and Δ BPND in the precommissural dorsal caudate (r = −0.62, p = 0.05).Discussion:REC AN have a positive association between endogenous DA release and anxiety in the dorsal caudate. This finding could explain why food‐related DA release produces anxiety in AN, whereas feeding is pleasurable in healthy participants. © 2011 by Wiley Periodicals, Inc. (Int J Eat Disord 2012)
Zinc Halide and Alkylzinc Complexes of a Neutral Doubly Base‐Stabilized Diborane(4)
Authors: Schulenberg Nikola , Litters Sebastian , Kaifer Elisabeth , Himmel Hans‐Jörg 
Published: May 2011

AbstractThe doubly base‐stabilized diborane(4) [HB(μ‐hpp)]2 (hpp = 1,3,4,6,7,8‐hexahydro‐2H‐pyrimido[1,2‐a]pyrimidinate) was used as a ligand in the first authenticated example of a dialkylzinc complex and the second example of a zinc halide complex featuring a neutral boron hydride as ligand. The three complexes [ZnCl2{HB(μ‐hpp)}2] (2), [ZnBr2{HB(μ‐hpp)}2] (3), and [ZnMe2{HB(μ‐hpp)}2] (4) were fully characterized. The bonding properties were analysed in detail. This analysis indicated a complex bonding situation involving not only the two hydrogen atoms, but also the two boron atoms of the [HB(μ‐hpp)]2 ligand.
Synthesis of α‐N‐Linked Glycopeptides
Authors: Colombo Cinzia , Bernardi Anna 
Published: May 2011

AbstractA practical synthesis of Nα‐fluorenylmethoxycarbonyl‐Nγ‐(2,3,4,6‐tetra‐O‐acetyl‐α‐D‐glycopyranosyl)‐L‐asparagine in the gluco and galacto series has been achieved by using the methodology developed by DeShong and co‐workers. The resulting α‐N‐linked glycosyl amino acids were used in a linear approach to the synthesis of glycopeptides featuring the unnatural α‐N‐glycosyl linkage. Activation conditions for both C‐ and N‐terminus elongation in solution have been defined. The main side‐reaction encountered was the formation of cyclization by‐products (aspartimide) from the activated amino acid during C‐terminus elongation. Appropriate condensing agents were identified, which allowed a high yield of dipeptide formation and no epimierization of the glycosyl amino acids. Conditions for sugar deacetylation have also been optimized. Solid‐phase synthesis (Fmoc protocol) conditions were explored and PyBROP was found to be the reagent of choice for the activaton of glycosyl amino acids. The synthesis of more complex α‐N‐linked glycopeptides has thus become feasible, which will allow the properties of these neo‐glycoconjugates to be studied.