bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simulation and Skill Training Facilities in Nursing Institutes at Uttarakhand
Authors: Goswami Garima , Sharma Suresh K. , Sharma Rakesh , Rani Ritu 
Published: May 2024

Background:
Simulation and skill development facilities are essential for the training and preparation of nursing students, which aids in their clinical readiness and professional development. The aim of the study was to assess simulation and skill training facilities, their utility in selected nursing institutes at Uttarakhand.

Materials and Methods:
This descriptive cross-sectional study was conducted in conveniently selected 16 nursing institutes at Uttarakhand (India). Data were collected from Nov. to Dec. 2019, through a face-to-face interview using a validated self-structured questionnaire. Descriptive and inferential statistics were used to analyze the data.

Results:
There were 16 institutes from four districts that participated in the study. Of these, five (31%) were government, and 11 (69%) were private. All nursing institutes (100%) had a nursing foundation lab, midwifery, and child health nursing lab, while only 44% of institutes had a medical surgical nursing skill lab. Among skill development facilities, the overall average number [mean (SD)] of mannequins was 3.90 (7.10); and high-fidelity simulators were 2.47 (7.1). In private institutes, the average period [mean (SD)] of laboratory usage was significantly higher than in government institutes [35.82 (6.57) vs 27.40 (5.22); p = 0.025]. The duration of lab usages was significantly associated with the age of the institute (p = 0.04).

Conclusions:
This study found inadequate simulation and skills training facilities and less utilization of those facilities. There is a great need to find out the key issues that lead to the unavailability and limited use of the required nursing skill development facilities.
Prevention Strategy for Ulcer Recurrence in Patients with Type II Diabetes Mellitus: A Quasi-Experimental Study
Authors: Suriadi  , Pratama Kharisma , Fahrain Jerry , Junaidi  , Herman  , Pradika Jaka , Kardiatun Tutur , Bhakti Wida Kuswida , Haryanto  , Suyasa Putu Dharma 
Published: May 2024

Background:
Many strategies exist to prevent diabetic ulcer recurrence, yet an effective method does not currently exist. This study evaluates the effectiveness of a prevention strategy to reduce ulcer recurrence in patients with Diabetes Mellitus (DM).

Materials and Methods:
A quasi-experimental, two group study was undertaken with 60 participants with type 2 DM. Two trained nurses participated in this study as study assistants. Participants were divided into two groups: the intervention group received preventive treatment, including examination and assessment, foot care, and an educational program; the control group received standard care using the five pillars of DM management in Indonesia.

Results:
An equal number of men (n = 30) and women (n = 30) participated in this study. Neuropathy was noted in 76.70% and 56.70% of patients in the intervention and control groups, respectively. Furthermore, 63.30% of patients in the control group and 56.70% in the intervention group had foot deformities. The recurrence rate was lower in the intervention group (13.30%) than in the control group (33.30%). Moreover, 83.30% in the control group and 76.70% in the intervention group did not smoke. The duration of DM in both groups was >9 years (50% in the intervention and 43.30% in the control group). There were no significant differences between the two groups, with mean (SD) in age (t29 = −0.87, p = 0.389), ankle-brachial index (t29 = −1.05, p = 0.144), and HbA1C (t26 = −0.35, p = 0.733).

Conclusions:
Prevention strategies combining examination and assessment, foot care, and educational programs can reduce ulcer recurrence in diabetic patients.
Experiences of Mothers Receiving Donated Embryos
Authors: Zandi Mitra , Dabaghi Sahar , Salimi Akinabadi Atefe , Bagheri-Lankarani Narges , Omani-Samani Reza , Abdolmaleki Mostafa 
Published: May 2024

Background:
The efficacy of Assisted Reproductive Techniques (ARTs) or technologies used to treat infertile couples has been approved. One such technique is embryo donation. However, there is insufficient knowledge of the experiences of mothers receiving donated embryos. Thus, the present study was conducted with the aim to determine the experiences of mothers receiving donated embryos.

Materials and Methods:
This qualitative conventional content analysis study was conducted in 2018 for 8 months (from February to September). The research setting was Royan Institute. Mothers receiving donated embryos were selected from among those who were pregnant or were at the postpartum stage using the purposive sampling method. A total of 15 interviews were performed with 13 participants. The qualitative data were collected using deep unstructured interviews and analyzed using the Graneheim and Lundman (2004) method in (version 10; VERBI GmbH, Berlin, Germany) software.

Results:
Data analysis resulted in 412 open codes that were then categorized into 7 main categories and their subcategories. The main categories were as follows: sociocultural constraint, feeling of insecurity in personal and family identity, protection of personal and family identity, confounded support, pressure and hardship, and achieving relative tranquility.

Conclusions:
The results of this study showed that the mothers who underwent embryo donation experienced feelings of insecurity regarding both individual and family identities, were confronted with sociocultural difficulties, and faced various pressures. It is suggested that future care plans be focused on the identity crisis of these families and the children resulting from these methods, and that future plans balance the socioeconomic pressures resulting from the use of these methods.
The Effect of Auriculotherapy on Nausea, Vomiting, and Anxiety in Patients Undergoing Elective Cesarean Section with Spinal Anesthesia: A Clinical Trial Study
Authors: Mousavi Fatemeh Sadat , Golmakani Nahid , Mohebbi-Dehnavi Zahra , Barzanooni Somayeh , Hormati Ahmad , Abdi Hamid 
Published: May 2024

Background:
Nausea, vomiting, and anxiety are common complications during and after spinal anesthesia. Auriculotherapy as a complementary medicine can be useful for reducing nausea, vomiting, or anxiety. This study was performed to evaluate the effects of auriculotherapy on nausea, vomiting, and anxiety in patients undergoing elective Cesarean Section (CS) with spinal anesthesia.

Materials and Methods:
The present study was a clinical trial study that was performed on 56 pregnant women selected as CS candidates in Ommolbanin Hospital in Mashhad during the years 2016–2017. In the intervention group, 1 h before spinal anesthesia, auricular acupoint stimulation was performed at four points bilaterally, for 20–30 seconds at each point. Evaluations were done by the following questionnaires: State-Trait Anxiety Inventory (STAI), Visual Analog Scale (VAS), and Vomiting Assessment Form.

Results:
The mean anxiety (SD) before the intervention in the intervention group and the control group was 47.88 (8.67) and 47.84 (10.49), respectively, and 4 h after the intervention, it was 40.23 (10.19) and 42.88 (12.18) in the intervention and control groups, respectively. These results were significant in the intervention group (p = 0.008). 30–40 min before and 4 h after the surgery, the severity of nausea and vomiting was low in both groups and no significant difference was observed between the two groups during the surgery and in the recovery room (p > 0.05).

Conclusions:
According to the results, auriculotherapy could reduce anxiety in CS patients with spinal analgesia. The results also showed that auriculotherapy reduced the severity of nausea and vomiting, but these changes were not significant.
Organizational Ethics Indicators in Iranian Hospital: An Importance-Performance Analysis
Authors: Shojaei Amir Ahmad , Mahbanooei Bahareh , Farahani Amin , Pourezzat Ali Asghar 
Published: May 2024

Background:
Organizational ethics focuses on the importance of how organizations behave when faced with specific situations and decisions. This study aims to identify and prioritize organizational ethics indicators in Imam Khomeini Hospital Complex (IKHC) in Iran.

Materials and Methods:
This was a mixed-method research project. To recognize hospital ethics indicators, 18 semistructured interviews were conducted and 38 indicators were identified through thematic analysis. In the next stage, a quantitative approach was adopted to use the importance-performance matrix for data analysis. This part was a descriptive survey with a statistical population consisting of nurses, medical, clinical, and administrative staff. The questionnaire was distributed using the random sampling method, and a total of 349 samples were collected.

Results:
Based on the interviews and open coding, 73 themes were identified for organizational ethics indicators and classified into two main groups: “ethics drivers in hospital” and “personal ethics.” After measuring content validity, 35 indicators of organizational ethics in IKHC were examined in terms of importance and performance. The results showed that nine indicators had high importance and poor performance, 11 had high importance and performance, nine had low importance and performance, and finally six indicators had low importance and high performance, and according to these findings, practical suggestions were put forward.

Conclusions:
Based on the identified indices and by applying importance-performance analysis, it is recommended to continually assess the status of ethics in hospitals and offer strategies for improving organizational ethics.
Exploring the Impacts of Caring for Hospitalized COVID-19 Patients on Nurses: A Qualitative Descriptive Study
Authors: Hosseini Meimanat , Ghasemi Saeed , Hejazi Sima 
Published: May 2024

Background:The impacts of caring for hospitalized COVID-19 patients on nurses are wide and varied and have not been comprehensively explained in the existing literature. The aim of this study was to explore the nurses’ perception of the impacts of caring for hospitalized COVID-19 patients.Materials and Methods:In this qualitative descriptive study, data were collected via semi-structured interviews with 20 nurses and head nurses of emergency/internal wards and Intensive Care Units (ICUs) of 2 hospitals in Tehran, Iran. The purposive sampling method was used, and data analysis was performed using a conventional content analysis approach.Results:After data analysis, 12 subcategories, 3 main categories, and 1 theme (professional resilience) were extracted. The three main categories included “complex care,” “professional development,” and “caring self-efficacy.” Caring for hospitalized COVID-19 patients was complex for nurses; however, the care provided to these patients could also lead to the nurses’ professional development and caring self-efficacy.Conclusions:Health organizations and nursing managers can better manage the COVID-19 pandemic and other similar future crises through strategies such as providing nurses with adequate and diverse resources and facilities, encouraging and supporting nurses in various dimensions, providing positive media advertisements for the nursing profession and nurses, and providing nurses with necessary and applicable knowledge and skills.
Intractable headaches secondary to a solitary lateral ventricle lesion of neurocysticercosis
Authors: Nisson Peyton Lubbock , Schievink Wouter I. , Chu Ray 
Published: May 2024

AbstractTaenia soliumis a parasitic tape worm that causes neurocysticercosis (NCC), which is classically characterized by scattered, intraparenchymal brain lesions. However, in very rare cases, a solitary, lateral ventricle lesion may be all that is present, which can make diagnosis difficult. Herein, we report the case of a 34-year-old female from Western Europe who presented with 12 days of intractable headaches. Magnetic resonance imaging revealed a single, heterogeneous appearing intraventricular mass with mild enhancement located in the left lateral ventricle near the foramen of Monro. Using a minimally invasive image-guided tubular retractor system for surgical biopsy and resection, NCC was identified on histological analysis. The patient tolerated the procedure well, and her headaches improved. Although NCC is associated with exposure to raw pork and/or prior residence in an endemic location, these are not always present. This case highlights the unusual radiographic findings and benign clinical history providers may encounter with NCC.
Anxiety and Depression among patients with melasma: A cross-sectional study
Authors: Kour Preeti , Soodan Puneet Singh , Singh Manmeet , Arora Raghav , Gupta Urvi 
Published: May 2024

Aim:
We aimed to study the frequency of anxiety and depression among melasma patients and its association with demographic variables.

Materials and Methods:
This cross-sectional study included 94 melasma patients attending a dermatology outpatient department in a tertiary care hospital. The sociodemographic variables were collected using semi-structured pro forma. Information regarding anxiety and depression was gathered using the Generalized Anxiety Disorder-7 (GAD-7) scale and Patient Health Questionnaire-9 (PHQ-9). Data obtained were analyzed statistically using the Statistical Package for the Social Sciences (SPSS) version 23.0.

Results:
The majority of melasma patients were female (81.9%). The mean age of the individuals was 32.32 ± 11.42 years. Mild, moderate, and moderately severe anxiety was reported by 34%, 39.4%, and 1.1% of the patients, respectively, using the GAD-7 questionnaire. 25.5% of the patients had no anxiety. PHQ-9 revealed that mild, moderate, and moderately severe depression was reported by 30.9%, 23.4%, and 17% of the respondents, respectively. 28.7% of patients had no depression. None of the individuals had severe depression. In both questionnaires, the association was statistically significant with age, gender, and education.

Conclusion:
There is a presence of anxiety and depression among patients with melasma that needs early detection and management.
Chest and upper abdominal computed tomography scan findings in patients with established breast cancer
Authors: Obike Ifeanyi Emmanuel , Omidiji Olubukola Abeni Titilayo , Irurhe Nicholas Kayode , Olowoyeye Omodele Abosede , Adeyomoye Adekunle Olakunle , Ihekuna Ogechi Augustina , Odukoya Olukemi Ololade 
Published: May 2024

Background:
Computed tomography (CT) of the chest and/or abdomen is usually done in patients with breast cancer for staging regardless of their grade, size, lymph node, or clinical signs/symptoms in Nigeria. This study aimed to determine the diagnostic yield of chest and upper abdominal CT for metastasis, metastatic pattern, and incidental findings in patients with breast cancer in our environment.

Methodology:
A retrospective study of all 300 confirmed breast cancer patients who reported for chest/abdominal computed tomographic scans in a tertiary diagnostic center in Lagos between October 2021 and December 2021. Data were extracted from their CT images/radiological reports and analyzed using SPSS version 23 for Windows, P <0.05.

Results:
Three hundred patients with established breast cancer were examined, within the age range of 24–83 years, median of 51 years, and mean of 50.91 ± 11.9 years. The majority were female 298 (99.3%) and within the 50–59-year (101, 33.7%) age group. Most had unilateral breast cancer 286 (95%) with left-sided predominance (146, 49%). Metastasis was seen in 183 (61%) patients with nodes being the most common site 158 (52.7%). Solitary metastasis was seen in 91 (30.3%) of the participants, predominating in the lymph nodes 69 (23%), followed by lungs 17 (5.7%), P < 0.01. Two-organ involvement was in 59 (19.7%), and the most common combination was lung and node 32 (10.7%), followed by liver and node 8 (2.7%). Metastasis was most common in the 50–59-year age group, 64 (21.3%).

Conclusion:
Chest and abdominal CT yielded a definitive diagnosis of metastasis in more than 50% of the patients. The most common structure affected was the lymph nodes. Chest CT is therefore imperative in patients with late presentation of breast cancer.
Relationship between computed tomography and histological features of gastrointestinal stromal tumors
Authors: Gunduz Nesrin , Dogan Mahmut Bilal , Seneldir Hatice , Ekinci Ozgur , Leblebici Ihsan Metin , Alimoglu Orhan 
Published: May 2024

Background and Aim:
Histomorphological and immunohistochemical (IHC) properties of gastrointestinal stromal tumors (GISTs) allow for accurate diagnosis and determine the prognosis. We aimed to evaluate the relationship between the computed tomography (CT) features, histomorphological properties, and IHC markers.

Materials and Methods:
This retrospective study comprised patients with pathologically confirmed GISTs between 2016 and 2021. The predefined CT characteristics comprised tumor size, hemorrhage and calcification, CT-growth pattern (exophytic/endophytic), and contrast enhancement pattern of the solid component (homogeneous/heterogeneous). The GISTs were divided into groups according to the National Institutes of Health risk category, cell type, presence of necrosis, CD117 and α-SMA positivity, and Ki-67 index. The frequencies of CT phenotypes were compared between groups.

Results:
Overall 24 (14 [58.3%] males) patients with a median age of 64 (59.5–75.5) having 25 GISTs were included. Of 25 GISTs, 16 (64%) were gastric and 9 (36%) were intestinal in origin. Among CT features, the maximum diameter was higher in epithelioid, infiltrative, a mitotic count ≥5/50, necrotic, high-risk GISTs (P < 0.05 for all). The median tumor size was higher in Ki-67 >8 than Ki-67 <6 subjects (112.5 [39.25–153.75] vs. 22.5 [16.75–57.5] mm, P = 0.014). A heterogeneous enhancement was also more frequent in Ki-67 >8 tumors (P = 0.04). The enhancement pattern did not differ according to CD-117 or SMA positivity. Logistic regression analysis revealed that the only independent predictor of a Ki-67 >8 status was the tumor size (odds ratio: 1.02, 95% confidence interval: 1.001–1.046, P = 0.04).

Conclusions:
Heterogeneously enhanced large GISTs at CT imaging strongly suggest the presence of poor prognostic factors including a high Ki-67 index and/or high-risk category.
Sonographic estimation of gestational age using transverse cerebellar diameter among late trimester pregnancies in Kano, Northwest Nigeria
Authors: Ado Maryam Sani , Suwaid Mohammad Abba , Dambatta Abdu Hamisu , Lawal Yusuf 
Published: May 2024

Background/Context:
Accurate estimation of fetal gestational age (GA) is of paramount importance in the management of all pregnancies, especially for the planning of mode of the delivery and management of high-risk pregnancies. Obstetric ultrasonography is a simple, available, affordable, and noninvasive modality for estimating fetal GA due to its high safety profile. The fetal cerebellum is easily visualized and reliably identified on ultrasound in the posterior cranial fossa after 14 weeks of gestation.

Aim:
The aim of this study was to evaluate the utility of transverse cerebellar diameter (TCD) in determining GA in second- and third-trimester pregnancies and compare its accuracy with other established sonographically derived fetal biometric parameters.

Materials and Methods:
A total of 424 pregnant women in their second and third trimesters who were sure of their last menstrual period (LMP) were recruited into the study over a period of 6 months (May to November 2019) at the Radiology Department of AKTH-Kano, Nigeria. The corresponding fetal TCD and other established fetal biometric indices (biparietal diameter [BPD], head circumference [HC], abdominal circumference [AC], and femur length [FL]) were sonographically obtained and correlated. Pearson’s bivariate coefficient was used to establish the correlation between the traditional biometric indices with TCD and GA derived by LMP. Multivariate linear regression analysis was used to assess the accuracy of the studied indices in predicting GA.

Results:
The range for TCD in second- and third-trimester fetuses was 15.9–57.5 mm. The TCD parameter was more accurate (±1.753 days) than BPD (±2.298 days), HC (±2.337 days), and AC (±4.342 days) and marginally less accurate than FL (±1.165 days) in predicting GA among study subjects (P < 0.001).

Conclusion:
TCD is a reliable and accurate parameter for GA estimation in late second- and third-trimester pregnancies when compared with established fetal biometric parameters among pregnant women in Kano, Nigeria.
Rapid Classification and Identification of Chemical Compounds and Semi-Quantitative Metabolism of Huangkui Capsules and the Protective Effects of Its Quercetin Derivatives against Tacrolimus-Induced HK-Cell Reduction
Authors: Zhang Feng , Weng Nan , Zhai Jian-Xiu , Jiao Guang-Yang , Wang Ye-Jian , Pang Tao , Liang Jing-Lei , Chen Yan-Hong , Huang Dou-Dou , Wang Zhi-Peng , Jun Han , Ma Yi-Yi , Tao Xia , Yin Jun , Chen Wan-Sheng 
Published: May 2024

Objective:
The study aimed to establish an effective strategy for systematically characterizing and verifying compounds in Huangkui capsules (HKCs).

Materials and Methods:
An ultrahigh-performance liquid chromatography quadrupole time-of-flight mass spectrometry (MS) method was effectively established and utilized for the chemical compound characterization in HKC, with the support of MS-DIAL, MS-FINDER, and Global Natural Product Social Molecular Network. Multiple rat samples were analyzed after the oral administration. Metabolites were identified based on specific cleavage behaviors, and metabolic pathways were predicted. Semi-quantitative analysis of the metabolome profiles was conducted using post-data processing. High concentrations in vivo were investigated for their role in tacrolimus-induced death of HK-2 cells.

Results:
In total, 129 compounds were identified in HKC, of which 74 were reported for the first time. In this study, we successfully identified and uncovered 19 prototypes and 123 metabolites from the biosamples. The concentrations of glucuronidation and methylation metabolites of quercetin were the highest in the kidney and intestinal tissues. In contrast, significant glucuronidation of quercetin metabolites was observed with high blood concentrations. Notably, quercetin glucuronidation and methylation metabolites protected HK-cell against tacrolimus-induced injury in a dose-dependent manner.

Conclusions:
This study successfully established a reliable and efficient strategy for comprehensive characterization of traditional Chinese medicine compounds. This strategy harnessed the power of various intelligent postprocessing technologies to provide a more thorough understanding of active components and their metabolic transformations in the body. These results suggest that quercetin metabolites should be evaluated for their protective capacity against kidney disease.