bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computable phenotype for diagnostic error: developing the data schema for application of symptom-disease pair analysis of diagnostic error (SPADE)
Authors: Hassoon Ahmed , Ng Charles , Lehmann Harold , Rupani Hetal , Peterson Susan , Horberg Michael A. , Liberman Ava L. , Sharp Adam L. , Johansen Michelle C. , McDonald Kathy , Austin J. Mathrew , Newman-Toker David E. 
Published: May 2024

Abstract

Objectives
Diagnostic errors are the leading cause of preventable harm in clinical practice. Implementable tools to quantify and target this problem are needed. To address this gap, we aimed to generalize the Symptom-Disease Pair Analysis of Diagnostic Error (SPADE) framework by developing its computable phenotype and then demonstrated how that schema could be applied in multiple clinical contexts.

Methods
We created an information model for the SPADE processes, then mapped data fields from electronic health records (EHR) and claims data in use to that model to create the SPADE information model (intention) and the SPADE computable phenotype (extension). Later we validated the computable phenotype and tested it in four case studies in three different health systems to demonstrate its utility.

Results
We mapped and tested the SPADE computable phenotype in three different sites using four different case studies. We showed that data fields to compute an SPADE base measure are fully available in the EHR Data Warehouse for extraction and can operationalize the SPADE framework from provider and/or insurer perspective, and they could be implemented on numerous health systems for future work in monitor misdiagnosis-related harms.

Conclusions
Data for the SPADE base measure is readily available in EHR and administrative claims. The method of data extraction is potentially universally applicable, and the data extracted is conveniently available within a network system. Further study is needed to validate the computable phenotype across different settings with different data infrastructures.
Optimization of biomass durian peel as a heterogeneous catalyst in biodiesel production using microwave irradiation
Authors: Ginting Binawati , Sitepu Minanda Payungta , Santoso Aman , Susilo Bambang , Tarigan Juliati Br. , Sitepu Eko Kornelius 
Published: May 2024

Abstract
The present study investigated biodiesel production from the transesterification of palm oil with methanol using calcined biomass durian peel (BDP) as a heterogeneous catalyst assisted by microwave irradiation. Characterization of the calcined BDP showed that K2O is the main compound with a concentration of 86.15 wt%. The effect of three independent variables of catalyst weight (3–12 wt%), reaction time (1–10 min), and power of microwave (180–900 W) was used to determine the optimum condition on biodiesel production using the response surface method-based on the Box–Behnken design experiment. The optimum biodiesel conversion of 97.3% was achieved under experimental parameters of catalyst concentration of 12 wt%, reaction time of 9 min, and microwave power of 180 W. The catalyst concentration and reaction time have significant effects on biodiesel conversion.
Unpaired cysteine insertions favor transmembrane dimerization and induce ligand-independent constitutive cytokine receptor signaling
Authors: Baumgärtner Lynn Affrica Felicitas , Ettich Julia , Balles Helene , Lapp Dorothee Johanna , Mossner Sofie , Bassenge Christin , Ouzin Meryem , Hanenberg Helmut , Scheller Jürgen , Floss Doreen Manuela 
Published: May 2024

Abstract
Naturally occurring gain-of-function (GOF) mutants have been identified in patients for a variety of cytokine receptors. Although this constitutive activation of cytokine receptors is strongly associated with malignant disorders, ligand-independent receptor activation is also a useful tool in synthetic biology e.g. to improve adoptive cellular therapies with genetically modified T-cells. Balanced Interleukin (IL-)7 signaling via a heterodimer of IL-7 receptor (IL-7Rα) and the common γ-chain (γc) controls T- and B-cell development and expansion, whereas uncontrolled IL-7 signaling can drive acute lymphoid leukemia (ALL) development. The ALL-driver mutation PPCL in the transmembrane domain of IL-7Rα is a mutational insertion of the four amino acids proline-proline-cysteine-leucine and leads to ligand-independent receptor dimerization and constitutive activation. We showed here in the cytokine-dependent pre-B-cell line Ba/F3 that the PPCL-insertion in a synthetic version of the IL-7Rα induced γc-independent STAT5 and ERK phosphorylation and also proliferation of the cells and that booster-stimulation by arteficial ligands additionally generated non-canonical STAT3 phosphorylation via the synthetic IL-7Rα-PPCL-receptors. Transfer of the IL-7Rα transmembrane domain with the PPCL insertion into natural and synthetic cytokine receptor chains of the IL-6, IL-12 and Interferon families also resulted in constitutive receptor signaling. In conclusion, our data suggested that the insertion of the mutated PPCL IL-7Rα transmembrane domain is an universal approach to generate ligand-independent, constitutively active cytokine receptors.
An analysis of exponential kernel fractional difference operator for delta positivity
Authors: Mohammed Pshtiwan Othman 
Published: May 2024

Abstract
Positivity analysis for a fractional difference operator including an exponential formula in its kernel has been examined. A composition of two fractional difference operators of order

(

ν
,
μ

)

\left(\nu ,\mu )

in the sense of Liouville–Caputo type operators has been analysed in cases when

ν
≠
μ

\nu \ne \mu

and

ν
=
μ

\nu =\mu

. Due to the kernel of the fractional difference operator being convergent, there has been a restriction in the domain of the solution. Incidentally, a negative lower bounded condition has been carried out through analysing the positivity results. For a better understanding, an increasing function has been considered as a test for the main results.
Influence of TLR4 signaling on cannabidiol’s antitumor effectiveness in lung adenocarcinoma cells
Authors: Kacaroglu Demet , Parlak Khalily Melek , Yaylacı Seher 
Published: May 2024

Abstract

Objectives
Lung cancer remains a predominant cancer type with high incidence and low survival rates. Key challenges in its treatment include impaired cellular mechanisms, notably resistance to apoptosis and altered immune responses. A critical aspect in this context is the heightened TLR4-mediated signaling, known to promote cell survival, metastasis, and resistance to cell death, particularly impacting immune microenvironment regulation. This study focuses on evaluating the impact of TLR4 signaling activation on potential therapeutic strategies.

Methods
Our research utilizes cannabidiol (CBD), a compound already employed in mitigating chemotherapy side effects in lung adenocarcinoma, recognized for its antitumor properties including antiproliferative, antimetastatic, and apoptosis-inducing effects. However, the effectiveness of CBD in lung cancer cells with elevated TLR4 signaling remains uncertain.

Results
Our findings reveal that the combination of CBD and TLR4 agonist affects cell viability, proliferation, cell cycle progression, apoptosis, and gene expression related to immune response and extracellular matrix regulation. In lung adenocarcinoma cells with activated TLR4, CBD shows an increased IC50 value, reflecting reduced antiproliferative capacity. Furthermore, its efficacy in arresting the cell cycle and inducing apoptosis is also compromised. The influence on immune response and extracellular matrix regulation is also altered in TLR4-activated cells.

Conclusions
These results indicate that TLR4 activation significantly diminishes the antitumor efficacy of CBD. This highlights the importance of considering TLR4 signaling activation in future research on therapeutic agents like CBD for cancer treatment.
Die wirtschaftlichen Folgen des Brexits
Authors: Breinlich Holger 
Published: May 2024

Abstract
The United Kingdom’s exit from the European Union (Brexit) has negatively affected its economic performance in the years after the 2016 referendum. A growing literature on the short-run effects of Brexit has documented that UK economic activity has been affected through a mix of uncertainty and anticipation effects. This literature has shown that UK GDP and investment have been negatively affected and inflation has increased as a consequence of the outcome of the referendum. Comparatively little is known about the effects of the UK’s subsequent exit from the single market and customs union in January 2021, but existing research has documented negative effects on UK trade, in particular UK imports from the European Union. But whether this will lead to subsequent further declines in UK GDP remains to be seen and will also depend on future EU-UK efforts to reduce the trade barriers created by the trade and cooperation agreement (TCA) of 2020.
New investigations in Gaza's heritage landscapes: the Gaza Maritime Archaeology Project (GAZAMAP)
Authors: Andreou Georgia Marina , Elkhoudary Yasmeen , Hassouna Ayman 
Published: May 2024

AbstractDecades of conflict in the Gaza Strip have contributed to widely documented cultural heritage destruction, demonstrating a need to monitor vulnerable sites and enhance the empirical base. This article describes how the Gaza Maritime Archaeology Project (GAZAMAP 2022–2023) was developed to monitor coastal and near-coastal sites, collaboratively. Owing to the unprecedented destruction of heritage since October 2023, GAZAMAP's scope has fundamentally shifted.
Assessment of Isokinetic Strength of Knee Extension/Flexion of Individuals With Intellectual Developmental Disabilities—Systematic Review With Protocol Proposal
Authors: Jacinto Miguel , Caseiro André , Antunes Raul , Monteiro Diogo , Campos Maria João , Matos Rui , Ferreira José Pedro , Gomes Beatriz 
Published: May 2024

ABSTRACT
Muscle performance is a crucial determinant of physical function in the daily lives of individuals with intellectual developmental disabilities (IDD), with lower strength levels often leading to loss of independence. The isokinetic dynamometer has been established as a reliable method for assessing muscle performance in this population. This article outlines the design of a protocol to be adopted to assess isokinetic knee strength in individuals with IDD. Using systematic review methodology, electronic searches were conducted in PubMed, Scopus, SPORTDiscus, and Web of Science databases, including articles published between January 1990 and September 2022. The key terms were combined with the Boolean operator “AND” or “OR”. After the methodological process, 23 studies were included for analysis. The protocol proposal consists of 8 phases, covering previous considerations: (a) warm-up, (b) familiarization; (c) equipment adjustment, choosing the limb to evaluate and in what type of action (concentric and/or eccentric); (d) number of repetitions and sets; (e) the rest duration; (f) angular velocity to be tested; and (g) parameters for analysis. It is intended that this article provide insights into the development of a useful tool for the various stakeholders interested in assessing the isokinetic knee strength of individuals with IDD.
Stitching of T-deep beams with large openings by CFRP sheets and NSM steel bars
Authors: Shakir Qasim M. , Yahya Yahya M. 
Published: May 2024

AbstractIn the present study, a comparison has been conducted to investigate the efficiency of stitching using the near-surface mounted steel bars and externally bonded carbon fibers reinforced polymers technique for strengthening the T-deep beams having large opening within the shear spans and with deficient shear reinforcement. Eight specimens with two locations of openings were tested. It was found that stitching of beams by steel bars with openings located flush to the flange yielded improvement in capacity in range (10–39%). Furthermore, Stitching by external bonded carbon sheets yield enhancements in capacity was 96 and 78% for the top location compared to the control specimen and the vertical near-surface mounted stirrups system. The respective values for the bottom location were 62 and 42% respectively.
SOCIODEMOGRAPHIC AND CLINICAL PROFILE OF FAMILIES AND INDIVIDUALS WITH AUTISM SPECTRUM DISORDER
Authors: Gomes da Silva Rocha Joelma , Mabely Azevedo Soares de Oliveira Karine , Guilherme Dieb Gomes Victor , Ruama Filgueira de Souza Ingrid , Coringa de Lemos Gustavo , Marques Medeiros e Silva Jaíza , De Almeida Barbosa Matheus 
Published: May 2024

Autism Spectrum Disorder (ASD) imposes limitations on individuals and their families, making it necessary to understand these realities to design effective interventions. Therefore, this study aimed to survey the sociodemographic and clinical data of families and individuals with ASD in Mossoró-RN. It is characterized as a descriptive, cross-sectional, and quantitative study, through an active search on social networks and using Google Forms. After the participants had given their consent, a form was used to gather data on the socio-economic and clinical situation of the families. The target population was families with individuals diagnosed with ASD and living in Mossoró - RN. The sample was by convenience, totaling 35 individuals with ASD. Among these, 80% were male, aged between 2 and 19, and the predominant races were white and brown (45.7% each). The most common professional at the time of diagnosis was the neuropediatrician (71.4%), and the most common feeling at this time was fear (34.3%). The diagnosis was received at a late stage by the majority (42.9%), and 25.7% felt satisfied with having received it. About being monitored by health professionals, the majority reported having been (97.1%); however, this monitoring is minimally provided by the Brazilian Unified Health System (SUS) (20%). The most frequently cited day-to-day difficulties were food restrictions (65.7%) and communication (62.9%). Concerning the caregivers' data, there was a prevalence of females (97.1%), with an age range from 23 to 53 years, married (65.7%), with a high school education (40%), and who did not work (54.3%), with a monthly income of one minimum wage (40%). The urban area prevailed as their home (97.1%). Based on these results, it was possible to identify a profile of individuals and families with ASD in the city of Mossoró, highlighting the need for more targeted public policies and assistance.
Kandungan nutrien dan fitohormon rumput laut cokelat dari Perairan Pulau Lemukutan Kalimantan Barat
Authors: Sofiana Mega Sari Juane , Mardini Delvia Devi , Safitri Ikha , Warsidah Warsidah , Nurdiansyah Syarif Irwan 
Published: May 2024

Pulau Lemukutan merupakan salah satu pulau kecil di Kecamatan Sungai Raya Kepulauan, Bengkayang, Kalimantan Barat. Keanekaragaman hayati di perairan pulau ini cukup tinggi dan melimpah, salah satunya adalah rumput laut. Rumput laut cokelat jenis Sargassum polycystum dan Padina australis paling banyak ditemukan di perairan ini dengan pemanfaatannya yang kurang optimal. Rumput laut cokelat telah banyak dilaporkan memiliki zat pengatur tumbuh (ZPT), mineral, dan senyawa bioaktif yang berpotensi sebagai biostimulan. Penelitian ini bertujuan untuk menentukan pH terbaik (asam, basa, dan netral) dalam mengekstrak kandungan nutrien dan fitohormon pada rumput laut S. polycystum dan P. australis asal perairan Pulau Lemukutan, Kabupaten Bengkayang, Kalimantan Barat. Nutrien tersebut diekstrak dari rumput laut dengan pH yang berbeda, yaitu 3, 7 dan 9. Ekstraksi dilakukan pada kondisi asam (SA dan PA), netral (SN dan PN) dan basa (SB dan PB). Kandungan nutrisi (N, P, K) dianalisis mengacu pada AOAC (Association of Official Analytical Chemist). Analisis fitohormon dilakukan dengan kromatografi cair kinerja tinggi (KCKT). Konsentrasi N, P dan K tertinggi yaitu 0,14% (SN dan PN); 0,03% (SA) dan 0,59% (SB). Hasil ini menunjukkan nutrien tertinggi terkandung pada S. polycystum dibandingkan P. australis. Fitohormon tertinggi terkandung pada S. polycystum, yaitu auksin 8,40 mg/g dan zeatin 17,99 mg/g.
Aktivitas antibakteri (Pseudomonas aeruginosa dan Staphylococcus aureus) dari ekstrak etanol selada air (Nasturtium officinale)
Authors: Hakim Salman Khaerul , Sudirman Sabri , Janna Miftahul , Nugroho Gama Dian , Sari Dwi Inda 
Published: May 2024

Bakteri merupakan mikroorganisme yang dapat menyebabkan pembusukan pada produk perikanan dan menyebabkan penyakit terhadap manusia. Senyawa polifenol dari ekstrak tumbuhan yaitu selada air merupakan salah satu sumber antibakteri alami. Tujuan penelitian adalah menentukan aktivitas antibakteri senyawa polifenol selada air (Nasturtium officinale) terhadap bakteri Pseudomonas aeruginosa dan Staphylococcus aureus. Senyawa polifenol diekstrak dengan metode maserasi menggunakan etanol 70%, kadar polifenol ekstrak ditentukan dengan metode Folin–Ciocalteu, dan aktivitas antibakteri dengan metode difusi sumuran Kirby-Bauer. Rendemen ekstrak diperoleh 21,62±1,55% dengan kadar polifenol 28,49 mg GAE/g sampel kering. Antibakteri menghasilkan peningkatan konsentrasi sampel yang berbanding lurus dengan penghambatan masing-masing bakteri. Diameter zona hambat pada konsentrasi 1 mg/mL pada P. aeruginosa yaitu 11,13 mm dan S. aureus 8,98 mm. Senyawa polifenol dari selada air dapat dijadikan sebagai agen antibakteri alami.
Desigualdad de derechos del trabajador padre cabeza de familia respecto a la trabajadora madre cabeza de familia en conexidad con los derechos del menor
Authors: Palomo Sandra Lucia 
Published: May 2024

Con relación a los derechos del trabajador en el marco civil, ellos pueden estar en situación de madre y padre cabeza de familia, en Derechos Fundamentales existen desigualdades en la legislación Colombiana frente al menor, en razón a que se ha enfocado a un sector limitado respecto al género, privilegiando a la mujer madre cabeza de familia que goza de una protección especial. El Estado tiene regulada estas garantías dirigidas a tutelar los derechos que en conexidad le atañen al menor de edad desde recién nacido. En Colombia, para el padre trabajador cabeza de familia, la Constitución Política y el ordenamientojurídico que se desprende de ella como la jurisprudencia, no establecen una equitativa protección.
Inovasi Media Presentasi Interaktif melalui Pelatihan Pemanfaatan Aplikasi Prezi
Authors: Amalia Dina , Nasyirin Bagus Khairun , Hana Shofiyatul 
Published: May 2024

Innovation in development of interactive presentation media through training in the use of Prezi application offers new potential in designing and delivering Pengabdian kepada Masyarakat (PkM) initiatives an interesting and effective way. This PkM aims to provide knowledge and creative presentation skills for MA Miftahul Huda Bulungan Jepara students through a practical and interactive approach using modern technology use Prezi application. The method for this service activity starts from introduction, implementation, and evaluation through pre-test and post-test questionnaires. Expected output will provide participants with the skills to produce more dynamic and interesting presentations, as well as a deeper understanding of the potential of Prezi's interactive features. PkM Gap Analysis in a holistic approach to developing presentation skills, combining technical aspects of using the Prezi application with increasing participant creativity. This innovation brings a training concept that does not only focus on technical skills, but also seeks a transformation in the way participants organize and present presentation materials through the Prezi application. Results of service obtained a pre-test score of 10% and a post-test score of 60%, an increase in scores showing that the training was successful in increasing effectiveness of presentations and enriching participants' experience through use of Prezi features.

Abstrak
Inovasi dalam pengembangan media presentasi interaktif melalui pelatihan pemanfaatan aplikasi Prezi menawarkan potensi baru dalam merancang dan menyampaikan inisiatif Pengabdian kepada Masyarakat (PkM) dengan cara yang menarik dan efektif. PkM ini bertujuan untuk memberikan pengetahuan dan ketrampilan presentasi yang kreatif bagi para siswa dan siswi MA Miftahul Huda Bulungan Jepara melalui pendekatan praktis dan interaktif menggunakan teknologi modern berupa aplikasi Prezi. Metode pada kegiatan pengabdian ini dimulai dari pendahuluan, pelaksanaan, dan evaluasi melalui angket pre test dan post test. Luaran yang diharapkan dapat memberikan peserta ketrampilan untuk menghasilkan presentasi yang lebih dinamis dan menarik, serta pemahaman lebih mendalam tentang potensi fitur-fitur interaktif yang dimiliki oleh Prezi. Analisis Gap PkM yaitu terletak pada pendekatan holistik terhadap pengembangan keterampilan presentasi, menggabungkan aspek teknis penggunaan aplikasi Prezi dengan peningkatan kreativitas peserta. Inovasi ini membawa konsep pelatihan yang tidak hanya memfokuskan pada keahlian teknis semata, tetapi juga mengupayakan transformasi dalam cara peserta menyusun dan menyajikan bahan presentasi melalui aplikasi Prezi. Hasil pengabdian diperoleh nilai pre test 10% dan nilai post test 60% kenaikan nilai menunjukkan pelatihan berhasil meningkatkan efektivitas presentasi dan memperkaya pengalaman peserta melalui penggunaan fitur-fitur Prezi.
State COVID-19 Policies and Drug Overdose Mortality Among Working-Age Adults in the United States, 2020
Authors: Wolf Douglas A. , Monnat Shannon M. , Wiemers Emily E. , Sun Yue , Zhang Xue , Grossman Elyse R. , Montez Jennifer Karas 
Published: May 2024

Objectives. To identify relationships between US states’ COVID-19 in-person activity limitation and economic support policies and drug overdose deaths among working-age adults in 2020. Methods. We used county-level data on 140 435 drug overdoses among adults aged 25 to 64 years during January 2019 to December 2020 from the National Vital Statistics System and data on states’ COVID-19 policies from the Oxford COVID-19 Government Response Tracker to assess US trends in overdose deaths by sex in 3138 counties. Results. Policies limiting in-person activities significantly increased, whereas economic support policies significantly decreased, overdose rates. A 1-unit increase in policies restricting activities predicted a 15% average monthly increase in overdose rates for men (incident rate ratio [IRR] = 1.15; 95% confidence interval [CI] = 1.09, 1.20) and a 14% increase for women (IRR = 1.14; 95% CI = 1.09, 1.20). A 1-unit increase in economic support policies predicted a 3% average monthly decrease for men (IRR = 0.97; 95% CI = 0.95, 1.00) and a 4% decrease for women (IRR = 0.96; 95% CI = 0.93, 0.99). All states’ policy combinations are predicted to have increased drug-poisoning mortality. Conclusions. The economic supports that states enacted were insufficient to fully mitigate the adverse relationship between activity limitations and drug overdoses. ( Am J Public Health. 2024;114(7):714–722. https://doi.org/10.2105/AJPH.2024.307621 )