bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of bark beetle disturbance and fuel types on fire radiative power and burn severity in the Bohemian-Saxon Switzerland
Authors: Beetz Kristina , Marrs Christopher , Busse Annika , Poděbradská Markéta , Kinalczyk Daniel , Kranz Johanna , Forkel Matthias 
Published: May 2024

Abstract
Until recently, forest fires were considered a rare phenomenon in the temperate forests of Central Europe because of the moderate summer temperatures and the humid climate. However, many of those forests (monocultures of Picea abies, Norway Spruce) were affected by bark beetle infestations in the past years and recent fires such as that in the Bohemian-Saxon Switzerland in 2022 raised widespread debates about the effects of forest mortality on fuel accumulation and hence fire occurrence and severity. Here, we aim to investigate the association of fire radiative power (FRP) and burn severity with fuel types during the fire in Bohemian-Saxon Switzerland in 2022. We enhanced a European fuel type classification with a class for dead and dying spruce and mapped pre-fire fuel types using data on habitats, tree species, bark beetle disturbances and tree coverage. FRP was derived from observations of the Visible and Infrared Radiometer Suite (VIIRS) sensors. Burn severity was quantified by the differenced normalized burn ratio (dNBR) through pre- and postfire Landsat 8, 9, and Sentinel-2 images and was assessed in the field using the Composite Burn Index (CBI). We found the highest FRP at sites with dead spruce forests. Burn severity was moderate with high variability across all fuel types but highest severities occurred in dead spruce stands. The dNBR correlated positively with char height and the presence of torched trees (R = 0.48, P &lt; .05), especially in dead spruce stands, likely due to the large amount of dry fine woody debris and the presence of initial natural regeneration. Our results demonstrate that surface fuel accumulation from past bark beetle disturbances resulted in more intense fires (higher FRP, char height and torching) and higher burn severity. The results highlight the need for improved cross-border fire risk management in Central European temperate forests that were previously not considered as fire-prone.
The Locative Function of Situated Art
Authors: Wilder Ken 
Published: May 2024

Abstract
This article proposes a locative function as a defining feature of situated art. All artworks orient their beholders, but situated art is characterized by this context-sensitive orientation entering the work’s content. In so doing, it facilitates ‘here’- and ‘now’-thoughts, not only towards the “real” situation encountered (the work’s outer orientation) but to the work’s “virtual” or “bracketed” realm (its inner orientation). These orientations overlap, but do not necessarily align; indeed, situated works often construct a tension through a deliberate miscalibration of these orientations. But what is the mechanism by which such works afford indexical thought towards their worlds? Drawing upon Gareth Evans’s account of demonstrative content, I contend that sensory imagination—conceived in Evans’s terms as an additional conceptual component—plays a necessary role in negotiating demonstrative thought towards two (or more) separate spaces conceived as “here.” This is something the beholder brings to the work.
Behaviour of Machine Learning algorithms in the classification of energy consumption in school buildings
Authors: Machado José , Chaves António , Montenegro Larissa , Alves Carlos , Durães Dalila , Machado Ricardo , Novais Paulo 
Published: May 2024

Abstract
The significance of energy efficiency in the development of smart cities cannot be overstated. It is essential to have a clear understanding of the current energy consumption (EC) patterns in both public and private buildings. One way to achieve this is by employing machine learning classification algorithms, which offer a broader perspective on the factors influencing EC. These algorithms can be applied to real data from databases, making them valuable tools for smart city applications. In this paper, our focus is specifically on the EC of public schools in a Portuguese city, as this plays a crucial role in designing a Smart City. By utilizing a comprehensive dataset on school EC, we thoroughly evaluate multiple ML algorithms. The objective is to identify the most effective algorithm for classifying average EC patterns. The outcomes of this study hold significant value for school administrators and facility managers. By leveraging the predictions generated from the selected algorithm, they can optimize energy usage and, consequently, reduce costs. The use of a comprehensive dataset ensures the reliability and accuracy of our evaluations of various ML algorithms for EC classification.
An unusual case of gallstone ileus 35 years post-cholecystectomy masked by an incisional hernia
Authors: Gordon Christian I , Molina Gabriel A , Diaz Johann S , Mancero Maria B , Heredia Andrea E , Parrales Diana E , Larco Jesus N 
Published: May 2024

Abstract
Gallstone ileus is an uncommon cause of mechanical bowel obstruction in patients with cholecystitis and gallstones who develop a fistula over time. In the post-cholecystectomy patient, the presence of gallstone ileus is extremely rare; these patients have different pathophysiological pathways, such as a spilled gallstone that subsequently erodes into the bowel, subtotal cholecystectomies, and diverticulae that can hold a gallstone for hidden several years. In these patients, the clinical presentations are unique because of their rarity and because the gallbladder had been previously removed. A high index of suspicion by the medical team is needed for diagnosis. We present the case of an 85-year-old male who had a history of cholecystectomy 35 years ago. He presented to the emergency department with intestinal obstruction. Since he had a hernia, it was thought to be the cause of the obstruction; however, during surgery, we were surprised to find a gallstone ileus. After surgery, he fully recovered.
Persistent pneumothorax after laparoscopic appendectomy in a patient who had undergone radical esophagectomy 5 years before: possible relationship with vulnerability of the hiatus after esophagectomy: a case report
Authors: Ishikawa Seiji , Hayashida Masakazu , Satoh Daizo , Mine Shinji , Kawagoe Izumi 
Published: May 2024

Abstract
Postoperative pneumothorax is a well-known but relatively rare complication after laparoscopic surgery. Herein, we report a case of persistent pneumothorax after laparoscopic appendectomy. A 57-year-old male, with a history of minimally invasive esophagectomy and intrathoracic gastric tube reconstruction 5 years before, underwent a laparoscopic appendectomy. A chest X-ray taken on postoperative Day 1 revealed the development of the right pneumothorax, which took more than 3 days to resolve spontaneously. Although the mechanism of postoperative pneumothorax was unclear, it seemed likely that the air that had replaced carbon dioxide in the peritoneal cavity migrated into the thoracic cavity through the esophageal hiatus, which was not covered by the peritoneum or pleura after surgical resection. The present case, together with our previous similar case, suggests that a history of esophageal cancer surgery per se increases the risk of pneumothorax after laparoscopic surgery, probably regardless of when this was performed.
Right paraduodenal hernia presenting with strangulated obstruction with intestinal malrotation: a case report
Authors: Tanaka Hideharu , Mitsutomoe Saki , Nagao Narutoshi , Komori Shuji , Suetsugu Tomonari , Iwata Yoshinori , Watanabe Taku , Tanaka Chihiro , Kawai Masahiko 
Published: May 2024

Abstract
A paraduodenal hernia is a rare cause of an internal hernia that may require massive bowel resection; prompt diagnosis and surgical treatment are essential. In cases of malrotation, strangulation may occur both inside and outside the hernial sac. Strangulation outside the hernial sac makes the preoperative diagnosis more difficult. Herein, we report a patient with a right paraduodenal hernia, intestinal malrotation, and strangulation outside the hernia. An 86-year-old woman was admitted to our hospital with abdominal pain. Enhanced computed tomography showed a closed-loop obstruction of the hypo-enhancing small bowel and absence of a horizontal duodenal leg. The patient underwent an emergency laparotomy and was diagnosed with strangulated bowel obstruction due to a right paraduodenal hernia and malrotation. The patient underwent resection of the ischemic ileum, closure of the hernial orifice, and repositioning of the intestine. The postoperative course was uneventful. The patient reported no abdominal discomfort after 7 months of follow-up.
An idiopathic severe macroglossia in a young adult patient: a rare case
Authors: Al Hariri Bassem , Hassan Muad Abdi , Sharif Muhammad , Mohamed Rawan S , Alsidig Hadil Altaj Altrify , Alsiddig Hind Altag Alteraify , Illahi Memon Noor 
Published: May 2024

Abstract
Macroglossia, an uncommon anatomical anomaly, can manifest as either congenital or acquired. The size of the tongue undergoes variations with age, peaking at 8 years and reaching full maturity at 18 years. Congenital macroglossia stems from diverse conditions, such as muscular hypertrophy, hemangioma, lymphangioma, Down syndrome, and others. Acquired macroglossia can result from malignancies, endocrine and metabolic disorders, chronic infectious diseases, and head and neck infections, among other factors. Additionally, extended-prone surgery can lead to its development. The incidence of macroglossia is likely underreported. This presentation is rare with only six reported cases in the literature.
A rare case of perforated Meckle’s diverticulitis: a case report
Authors: Carlaw Kirsten R , Liyanage Chandika 
Published: May 2024

Abstract
Meckle’s diverticulum is the most common embryological anomaly of the small bowel that is rarely seen in adults. It is caused by the incomplete closure of the vitelline or omphalomesenteric duct. Those who are symptomatic from Meckle’s diverticulum have varied clinical presentations, which raise significant challenges with diagnostic and management options. We report a case of a 47-year-old male who presented to the hospital with clinical signs of appendicitis but was found to have perforated Meckle’s diverticulitis with faecoliths on computed tomography imaging and laparoscopy. Furthermore, histopathology revealed an ectopic gastric tissue cell type, which is a rare finding. This was definitively managed surgically with laparoscopic resection of Meckle’s diverticulum and appendicectomy.
Bilateral tinnitus associated with a diffuse astrocytoma of Heschl’s gyrus: a case report and review of literature
Authors: Aboulhosn Rabii , Bodkin Peter 
Published: May 2024

Abstract
Auditory processing is initiated within the primary auditory cortex, concealed within the sylvian fissure bilaterally on a collection of gyri described as Heschl’s Gyrus (HG). Glial neoplasms localized to or involving HG are rare. The main symptoms of these tumours are complex partial seizures characterized by auditory features. Here, we describe an unusual case of bilateral tinnitus and hemi-paraesthesia associated with a HG diffuse astrocytoma. Bilateral tinnitus secondary to intrinsic brain tumours is atypical. Bilateral tinnitus is frequently observed in patients with noise-induced hearing loss, presbycusis, ototoxic medication, and metabolic and psychiatric disease. In the case we present, the synchronous sensory and auditory symptoms are likely due to seizure activity affecting the primary auditory and somatosensory cortex. In a patient presenting with chronic, bilateral tinnitus with no known underlying otologic disease which is associated with hemi-body paraesthesia, we would advocate for consideration of brain imaging to exclude pathology in HG.
A ruptured mesenteric lymphangioma causing peritonitis: a case report
Authors: Kharkhach Ayoub , Rhoul Chafik , Police Andrea , Mabilia Andrea 
Published: May 2024

Abstract
Cystic lymphangioma is a rare disease that is mainly diagnosed in childhood. When diagnosed, the lesion presents an indication for surgery due to the risk of serious complications. Herein, we report the case of a 32-year-old patient who presented to the emergency room for abdominal pain that developed 2 days before with worsening symptoms and abdominal pain in the last 24 hr. The computed tomography showed diffuse wall thickening of the jejunum and proximal ileum with mesenteric fat infiltration, a mesenteric collection, and a moderate volume of ascites extending into the pelvis. A laparotomy was performed, revealing diffuse chemical peritonitis with a crater-like lesion in the jejunal mesentery, secreting lymphatic fluid. The mesenteric lesion was then excised, and the histological examination showed a ruptured cystic lymphangioma. Lymphangiomas of the small bowel mesentery are rare and may be exceptionally associated with bowel occlusion or peritonitis.
Comprehensive genomic profiling of pediatric peritoneal mesothelioma: case report with a literature review
Authors: Redzepagic Jasmina , Zvizdic Zlatan , Bilalovic Nurija , Milisic Emir , Bukvic Melika , Vranic Semir 
Published: May 2024

Abstract
Malignant peritoneal mesothelioma is an extremely rare and poorly recognized neoplasm in children. A 5-year-old boy presented with a 1-year history of progressive painless abdominal distension. A CT revealed a 19 × 19 × 11 cm3 cystic mass in the right hemiabdomen, without infiltrating the surrounding structures. The tumor was completely removed by surgery. The microscopic and immunohistochemical analyses confirmed peritoneal mesothelioma. Comprehensive genomic profiling revealed no major driving mutations including BAP1, no fusions, but with amplifications of AURKA, AURKC, HLA-1B, ZNF-217, OR5F1 and MEN1 genes. Imaging follow-up 3 months after surgery revealed metastatic disease. The patient died of pneumonia at another hospital shortly after the last follow-up examination at our institution. Pediatric peritoneal mesothelioma is an extremely rare malignancy with limited targeted options and a poor prognosis. Some of the identified molecular genomic biomarkers require further exploration and validation in this cancer.
Amyand’s hernia repair in an asymptomatic patient—a case report and a review of the literature
Authors: Smyrlis Nikolaos V , Mouratidis Stylianos Vladimiros P , Makedos Panagiotis I , Georgakis Konstantinos S 
Published: May 2024

Abstract
Amyand’s hernia is a rare condition, in which the appendix is found in the inguinal hernia sac. Many patients remain asymptomatic and this pathological condition is most commonly diagnosed intraoperatively. We report a case of a 66-year-old male who was admitted to the hospital for an inguinal hernia repair and the presence of the appendix in the inguinal hernia sac was discovered intraoperatively. We performed a reduction of the appendix in the abdominal cavity and a hernia repair with a mesh and a plug. There are few studies in literature about the appropriate method of treatment and, because of that, the therapeutic approach remains controversial. Therefore, we also conducted a review of the literature in order to obtain some conclusions regarding the management of Amyand’s hernia.
Neutropenic Sepsis in the Intensive Care Unit: Differences in Clinical Profile and Outcomes According to the Cause of Neutropenia
Authors: MacPhail Aleece , Dendle Claire , Slavin Monica , Weinkove Robert , Bailey Michael , Pilcher David , McQuilten Zoe 
Published: May 2024

Abstract

Background
Neutropenic sepsis frequently requires admission to an intensive care unit (ICU). Differences between subgroups of patients with neutropenic sepsis are not well characterized.

Aims
To investigate clinical outcomes among patients with neutropenic sepsis and hematological malignancy, metastatic solid cancer, or no cancer diagnosis.

Methods
Retrospective cohort study of all patients admitted to ICU in Australia or New Zealand between January 2000 and December 2022 with a primary admission diagnosis of sepsis and total white cell count &lt;1.0 × 109 cells/L.

Results
We identified 8617 ICU admissions with neutropenic sepsis (hematological malignancy n = 4660; metastatic solid cancer n = 1034; no cancer n = 2800). Patients with hematological malignancy were younger (median, 61.5 years) with low rates of chronic comorbidities (4.7%) and were usually admitted to ICU from the ward (67.4%). Mechanical ventilation rates were 20.2% and in-hospital mortality was 30.6%. Patients with metastatic solid cancers were older (median, 66.3 years), with higher rates of chronic comorbidities (9.9%), and were usually admitted to the ICU from the emergency department (50.8%). Mechanical ventilation rates were 16.9% and in-hospital mortality was 42.4%. Patients with no documented cancer had highest rates of mechanical ventilation (41.7%) and mortality (46.3%). Neutropenia was independently associated with mortality among patients with solid cancers or no cancer but did not confer increased risk among patients with hematological malignancy (odds ratio, 0.98; 95% confidence interval, .90–1.06; P = .60).

Conclusions
Patients with neutropenic sepsis and hematological malignancy, metastatic solid cancer, or no cancer diagnosis constitute 3 distinct clinical groups. Management approaches should be tailored accordingly.
Learning to learn: Single session acquisition of new rules by freely moving mice
Authors: Levi Amir , Aviv Noam , Stark Eran 
Published: May 2024

Abstract
Learning from examples and adapting to new circumstances are fundamental attributes of human cognition. However, it is unclear what conditions allow for fast and successful learning, especially in nonhuman subjects. To determine how rapidly freely moving mice can learn a new discrimination criterion (DC), we design a two-alternative forced-choice visual discrimination paradigm in which the DCs governing the task can change between sessions. We find that experienced animals can learn a new DC after being exposed to only five training and three testing trials. The propensity for single session learning improves over time and is accurately predicted based on animal experience and criterion difficulty. After establishing the procedural learning of a paradigm, mice continuously improve their performance in new circumstances. Thus, mice learn to learn.
Impact of the 2022 African Cup of Nations mass-gathering event on the COVID-19 epidemic in Garoua, Cameroon
Authors: Berland Jean-Luc , Njifon Hermann , Westeel Emilie , Moumbeket Henri , Komurian-Pradel Florence , Ilouga Pauliana , Njouom Richard , Perraut Ronald 
Published: May 2024

Abstract

Background
The 2022 African Cup of Nations (AFCON) took place in Cameroon from January 9th to February 5th, 2022, including Garoua in the north. We aimed to measure the impact of this event on the local COVID-19 epidemic given the implementation of a preventive strategy based on a health pass.

Methods
All players, staff and fans involved in the AFCON event were screened with PCR tests. Symptomatic cases were also continuously monitored in the general population and screened for variants of concern. Daily numbers of confirmed cases were compared to neighboring countries numbers retrieved from a public domain source.

Results
In total, 1479 and 2481 tests were performed in the general population and on asymptomatic AFCON attendees, respectively. From the latter, 12.5% were PCR-positive; 97% were infected with Omicron, with no significant difference compared to the passive program (G-test, P value = 0.162). Surveillance indicated the AFCON did not increase the number of symptomatic PCR-positive cases in the general population compared to neighboring countries.

Conclusions
Though the COVID-19 epidemic was fueled by asymptomatic cases infected with the Omicron variant at the time, the non-therapeutic preventive measures implemented for AFCON mitigated an increase in the epidemic in the local population.
Arbutin abrogates cisplatin-induced hepatotoxicity via upregulating Nrf2/HO-1 and suppressing genotoxicity, NF-κB/iNOS/TNF-α and caspase-3/Bax/Bcl2 signaling pathways in rats
Authors: Okkay Irmak Ferah , Famurewa Ademola , Bayram Cemil , Okkay Ufuk , Mendil Ali Sefa , Sezen Selma , Ayaz Teslime , Gecili Ibrahim , Ozkaraca Mustafa , Senyayla Selcuk , Hacimuftuoglu Ahmet 
Published: May 2024

Abstract
Background: Cisplatin is a potent anticancer agent widely employed in chemotherapy. However, cisplatin leads to toxicity on non-targeted healthy organs, including the liver. We investigated the hepatoprotective mechanism of arbutin (ARB), a glycosylated hydroquinone, against cisplatin-induced hepatotoxicity. Methods: Rats were orally administered with ARB (ARB1 = 50 mg/kg; ARB2 = 100 mg/kg) for 14 consecutive days against hepatotoxicity induced by a single dose of cisplatin (10 mg/kg) on day 15. Three days after the intraperitoneal cisplatin injection, serum and liver tissue were collected for subsequent analyses. Results: Cisplatin triggered marked increases in serum AST, ALT, and ALP activities, hepatic malondialdehyde (MDA) and reactive oxygen species (ROS) coupled with a considerable diminution in hepatic activities of superoxide dismutase (SOD), catalase (CAT) and the concentration of reduced glutathione (GSH). The gene expressions of interleukin-1β (IL-1β), tumor necrosis factor (TNF-α), and IL-6 were notably increased. The pre-administration of ARB1 and ARB2 reduced AST, ALT and ALP in serum and restored SOD, CAT, GSH, ROS, MDA and cytokine levels which was also evidenced by alleviated hepatic lesions. Further, cisplatin-induced prominent alterations in the gene expressions of nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), iNOS, NF-κB, Bax, Bcl-2, caspase-3 and 8-OHdG in the liver. Interestingly, ARB protected the liver and mitigated the cisplatin-induced alterations in serum AST, ALT, ALP, and reduced hepatic redox markers, 8-OdG, inflammatory markers and gene expressions. Conclusion: The findings demonstrate that ARB is a potential protective adjuvant against cisplatin-induced hepatotoxicity via inhibition of hepatic oxidative stress, inflammation, and apoptosis.
Enhancing Gene Expression Representation and Drug Response Prediction with Data Augmentation and Gene Emphasis
Authors: Lu Diyuan , Pamar Daksh P.S. , Ohnmacht Alex J. , Kutkaite Ginte , Menden Michael P. 
Published: May 2024

ABSTRACTRepresentation learning for tumor gene expression (GEx) data with deep neural networks is limited by the large gene feature space and the scarcity of available clinical and preclinical data. The translation of the learned representation between these data sources is further hindered by inherent molecular differences. To address these challenges, we propose GExMix (GeneExpressionMixup), a data augmentation method, which extends the Mixup concept to generate training samples accounting for the imbalance in both data classes and data sources. We leverage the GExMix-augmented training set in encoder-decoder models to learn a GEx latent representation. Subsequently, we combine the learned representation with drug chemical features in a dual-objective enhanced gene-centric drug response prediction, i.e., reconstruction of GEx latent embeddings and drug response classification. This dual-objective design strategically prioritizes gene-centric information to enhance the final drug response prediction. We demonstrate that augmenting training samples improves the GEx representation, benefiting the gene-centric drug response prediction model. Our findings underscore the effectiveness of our proposed GExMix in enriching GEx data for deep neural networks. Moreover, our proposed gene-centricity further improves drug response prediction when translating preclinical to clinical datasets. This highlights the untapped potential of the proposed framework for GEx data analysis, paving the way toward precision medicine.