bluuebunny/crossref_metadata_2025_split huggingface dataset:
Angiomotin family proteins in the Hippo signaling pathway
Authors: Wang Yu , Yu Fa‐Xing 
Published: May 2024

AbstractThe Motin family proteins (Motins) are a class of scaffolding proteins consisting of Angiomotin (AMOT), AMOT‐like protein 1 (AMOTL1), and AMOT‐like protein 2 (AMOTL2). Motins play a pivotal role in angiogenesis, tumorigenesis, and neurogenesis by modulating multiple cellular signaling pathways. Recent findings indicate that Motins are components of the Hippo pathway, a signaling cascade involved in development and cancer. This review discusses how Motins are integrated into the Hippo signaling network, as either upstream regulators or downstream effectors, to modulate cell proliferation and migration. The repression of YAP/TAZ by Motins contributes to growth inhibition, whereas subcellular localization of Motins and their interactions with actin fibers are critical in regulating cell migration. The net effect of Motins on cell proliferation and migration may contribute to their diverse biological functions.
Lithium spreading layer consisting of nickel particles enables stable cycling of aluminum anode in all‐solid‐state battery
Authors: Chai Jingjing , Song Libo , Li Zhendong , Peng Zhe , Yao Xiayin 
Published: May 2024

AbstractDeveloping promising substitutes of lithium (Li) metal anode that suffers from a serious interfacial instability against the solid electrolyte (SE) is a formidable challenge for the all‐solid‐state battery. Aluminum (Al), a highly potential candidate owing to its high specific capacity and relatively low working potential, however, cannot withstand stable cycling in all‐solid‐state battery due to the fast structural collapse caused by the solid/solid contact at the Al/SE interface. Herein, a Li spreading layer consisting of metallic nickel (Ni) particles at the Al surface is proposed to raise the performance of Al anode in all‐solid‐state battery. Owing to the immiscibility between Ni and Li solid phases, this Li spreading layer can enable a uniform distribution of Li atoms over the electrode surface followed by a stable Li–Al alloying/dealloying processes, suppressing the stress deformation at the Al/SE interface and significantly improving the cycling performance of Al anode in all‐solid‐state battery. The modified Al anode not only outperforms the bare Al significantly, but also exhibits superior cyclability and rate ability compared with the Li anode. This work provides an efficient strategy to promote the application of Al anode in all‐solid‐state battery, and is expected to be generalized for other alloy anodes.
Uncommon Epoxyquinols Pyrrolocytosporin A and Cytosporin E2 from the Fungus Eutypella sp. D‐1
Authors: Yu Hao‐Bing , Du Lin , Ning Zhe , Lu Xiao‐Ling , Jiao Bing‐Hua , Hu Bo , Liu Xiao‐Yu 
Published: May 2024

AbstractTwo uncommon epoxyquinols, pyrrolocytosporin A (1) and cytosporin E2 (2), along with the known cytosporin Y1 (3), were isolated from the solid defined medium of the Arctic‐derived fungus Eutypella sp. D‐1. Their structures were established through comprehensive analyses of spectroscopic and electronic circular dichroism data. Structurally, compound 1 represented the first nitrogen‐containing epoxyquinol characterized by a pyrrole fused cytosporin framework, while compound 2 contained an uncommon cyclic carbonate functionality. The antibacterial, immunosuppressive, anti‐inflammatory, and cytotoxic activities of all compounds were evaluated. Among the three metabolites, only compound 1 exhibited inhibitory effects on nitric oxide production induced by lipopolysaccharide with an IC50 value of 6.55 μM. Additionally, only compound 2 displayed inhibitory activity against ConA‐induced T‐cell proliferation with an IC50 value of 9.85 μM.
Reductive Electrophotocatalytic α‐C−H Arylation of Cyclic Ketones with Aryl Chlorides
Authors: Aman Hasil , Chang Rui , Ye Juntao 
Published: May 2024

Abstractα‐Aryl cyclocarbonyls are important building blocks in organic synthesis. While many methods have been developed for their synthesis, the use of readily available and inexpensive aryl chlorides as the arylating reagent remains rare. Herein, we report an α‐arylation of cyclic ketones with aryl chlorides under reductive electrophotocatalytic conditions. 2,6‐Diisopropylphenyl‐containing naphthalenemonoimide was identified as the optimal electrophotocatalyst, allowing for use of electron‐deficient as well as electron‐rich aryl chlorides under mild conditions.
Starch‐based nanoparticles as a replacement for synthetic latex: A comprehensive assessment of printability and colorimetric characteristics
Authors: Altay Bilge N. , Carver‐Kubik Al , Williams Scott , Huq Anamika , Sugiyama Maya , Dhote Yash , Zunjarrao Apurva , Aydemir Cem , Karademir Arif 
Published: May 2024

AbstractThe papermaking, packaging, and printing industry are actively seeking sustainable material alternatives to address growing concerns about environmental consciousness and finite resources. Synthetic latex, a frequently utilized binder in paper coating formulations, present difficulties due to their dependence on fossil fuel resources and their reduced recyclability in comparison to eco‐friendly sustainable products. In this study, synthetic latex was replaced with a starch‐based nanoparticle (starch NP) binder at a 1:1 ratio in a coating formulation. Printing trials to assess colorimetric characteristics was made using electrophotography (EP) printing, given the current upward trajectory and expansion of EP technology into the label, packaging, and folding carton sectors. The in‐depth investigations reveal that incorporating starch NP binder result in improved optical, color, and dot characteristics. Moreover, it maintains consistent and comparable coefficients of friction. Partial replacement of synthetic latex with the starch NP binder yields significant enhancements in surface roughness and text quality. Importantly, the starch NP binder not only improves the dielectric relaxation properties of the paper and enhances toner transfer but also accelerates the distribution of the electrical field compared to synthetic latex, optimizing toner transfer and thereby enhancing color gamut volume. The study demonstrates that employing the starch NP binder leads to substantial improvements in colorimetric performance without any drawbacks in EP printing, making it highly advantageous to replace 50% of the synthetic binder.
Evidence of field‐scale shifts in transpiration dynamics following bark beetle infestation: Stomatal conductance responses
Authors: Li Meijun , Shao Wei , Su Ye , Coenders‐Gerrits Miriam , Jarsjö Jerker 
Published: May 2024

AbstractAmplified eruptive outbreaks of bark beetles as a consequence of climate change can cause tree mortality that significantly affects terrestrial water and carbon fluxes. However, the lack of field‐scale observations of underlying physiological mechanisms currently hampers the expression of such ecosystem disturbances in predictive modelling. Based on a unique flux tower dataset from a subalpine forest located in the Rocky Mountains, mechanisms of stomatal response to an extensive bark beetle outbreak were investigated using various models and parametrizations. The datasets cover a decade, including the periods of pre‐infestation, infestation, and post‐infestation. Field measurements showed considerable decreases in evapotranspiration (ET), transpiration (T), and leaf area index (LAI) during the two‐year infestation period compared to the pre‐infestation period. Model interpretations of observed water and carbon fluxes indicated that the overall reductions in T were not solely due to decreased LAI, but also to changes in physiological behaviours. The summer season's canopy‐scale stomatal conductance was significantly reduced during the infestation period, from 0.0018 to 0.0011 m s−1. One primary reason for the observed variations is likely that the bark beetle infestation hampers the water transport in the xylem. The damage of xylem has important implications for water use efficiency (WUE), which also significantly influences the parameterization of stomatal conductance. When using stomatal conductance models to forecast ecosystem dynamics, it is crucial to recalibrate the model's parameters to ensure the accurate depiction of stomatal dynamics during various infestation periods. The neglect of the temporal variability of canopy‐scale stomatal conductance under ecosystem disturbances (e.g., bark beetle infestations) in current earth system models, therefore, requires specific attention in assessments of large‐scale water and carbon balances.
Literature review, surgical decision making algorithm, and AGREE II‐S comparison of national and international recommendations and guidelines in pelvic organ prolapse surgery
Authors: Pecorella Giovanni , Morciano Andrea , Sparic Radmila , Tinelli Andrea 
Published: May 2024

AbstractThe average lifespan has increased over time due to improvements in quality of life, leading to an aging population that stays healthy for longer. Pelvic organ prolapse (POP), whether uterine or vaginal, is a problem that severely impairs quality of life and imposes significant restrictions. The present study provides the reader with a summary of the many surgical techniques used in POP surgery, comparing international guidelines, offering an algorithm that is simple to understand, and allows the reader to quickly choose the table that includes the best surgical therapy for each individual. Using relevant keywords, the writers searched the PubMed and Scopus databases for relevant publications from 2000 to April 2023. Studies with cases of oncologic disorders or prior hysterectomy performed for another reason were not included in the analysis. Ten distinct international guidelines are highlighted and examined in the present study. We used the Appraisal of Guidelines for Research and Evaluation II‐S (AGREE II‐S) method to assess their quality, and incorporated the results into the conclusion. Worldwide, anterior colporrhaphy is the preferred method of treating anterior compartment abnormalities, and mesh is virtually always used when recurrence occurs (which happens in about half of the cases). Worldwide, posterior colporrhaphy is commonly used to repair posterior compartment abnormalities. Only a few national guidelines (the Iranian guideline, Acta Obstetricia et Gynecologica Scandinavica [AOGS], and the German‐speaking countries) permit the use of mesh or xenograft in cases of recurrence. There is agreement on the abdominal approach (sacrocolpopexy) with mesh for treating apical deformities. Sacrospinous‐hysteropexy is the standard method used to guide the vaginal approach; mesh is typically used to aid in this process. There are just three recommendations that do not include vaginal operations: HSE, AOGS, and Iran. Of obliteration techniques, colpocleisis is unquestionably the best. In conclusion, our analysis highlights the significance of customized methods in POP surgery, taking into account the requirements and preferences of each patient. To choose the best surgical therapy, criteria and patient features must be carefully considered.
An attachment‐based program for parents of youth with clinically significant mental health problems: Scaling up and drilling down to mechanisms of change
Authors: Moretti Marlene M. , Dys Sebastian P. , Craig Stephanie G. , Sierra Hernandez Carlos A. , Goulter Natalie , O’Donnell Katherine , Pasalich Dave S. 
Published: May 2024

AbstractBackgroundGiven the prevalence and recent increases in youth mental health problems, there is a pressing need for interventions that target transdiagnostic protective factors that could be targeted as mechanisms of change in treatment. Such interventions are most likely to succeed in meeting population needs if they are scalable, sustainable, and effective. Connect is a manualized, 10‐session trauma‐informed and attachment‐based parent program that is structured, emotion‐focused and skills‐oriented. Developed for broad implementation by community mental health workers, Connect is designed to promote parent–child attachment security, a well‐established transdiagnostic protective factor for youth mental health.MethodsWe examined whether parent–youth attachment anxiety and avoidance predicted reductions in internalizing and externalizing problems in a large one‐group clinical sample of youth (N = 527; ages 8–18 years) of parents (N = 690) who completed the Connect program in a longitudinal study with 6 time points (pre‐, mid‐, and post‐treatment; 6‐, 12‐ and 18‐month follow‐up).ResultsFindings confirmed that parent and youth reports of attachment anxiety and avoidance, as well as internalizing and externalizing problems, significantly declined over the course of the intervention. Parent reported reductions in youth attachment anxiety, but not avoidance, predicted declining levels of youth internalizing problems. As well, parent reported reductions in youth attachment avoidance and anxiety predicted declining youth externalizing behavior. In contrast, youth reports of reductions in youth attachment anxiety, but not attachment avoidance, were associated with declines in youth externalizing problems.ConclusionOur findings support the role of attachment as an important transdiagnostic mechanism of change in attachment‐based programs for parents of teens with clinically significant mental health problems.
Simple and efficient synthesis of pyrrolo[3,2‐f]quinoxaline derivatives via three‐component reaction
Authors: Wan Dan‐Dan , Qian Yu‐heng , Liu Jia‐Yan , Chen Dong‐Sheng 
Published: May 2024

AbstractA series of pyrrolo[3,2‐f]quinoxaline derivatives have been obtained by a three‐component domino reaction of quinoxalin‐6‐amine, arylglyoxal monohydrates, and cyclic 1,3‐dicarbonyl compounds in ethanol medium at 80°C catalyzed by acetic acid. The notable features of this synthesis are excellent regioselectivity, operational simplicity, relatively mild reaction conditions, and good yields.
Current trends in the prevention of adhesions after zone 2 flexor tendon repair
Authors: Vinitpairot Chaiyos , Yik Jasper H. N. , Haudenschild Dominik R. , Szabo Robert M. , Bayne Christopher O. 
Published: May 2024

AbstractTreating flexor tendon injuries within the digital flexor sheath (commonly referred to as palmar hand zone 2) presents both technical and logistical challenges. Success hinges on striking a delicate balance between safeguarding the surgical repair for tendon healing and initiating early rehabilitation to mitigate the formation of tendon adhesions. Adhesions between tendon slips and between tendons and the flexor sheath impede tendon movement, leading to postoperative stiffness and functional impairment. While current approaches to flexor tendon repair prioritize maximizing tendon strength for early mobilization and adhesion prevention, factors such as pain, swelling, and patient compliance may impede postoperative rehabilitation efforts. Moreover, premature mobilization could risk repair failure, necessitating additional surgical interventions. Pharmacological agents offer a potential avenue for minimizing inflammation and reducing adhesion formation while still promoting normal tendon healing. Although some systemic and local agents have shown promising results in animal studies, their clinical efficacy remains uncertain. Limitations in these studies include the relevance of chosen animal models to human populations and the adequacy of tools and measurement techniques in accurately assessing the impact of adhesions. This article provides an overview of the clinical challenges associated with flexor tendon injuries, discusses current on‐ and off‐label agents aimed at minimizing adhesion formation, and examines investigational models designed to study adhesion reduction after intra‐synovial flexor tendon repair. Understanding the clinical problem and experimental models may serve as a catalyst for future research aimed at addressing intra‐synovial tendon adhesions following zone 2 flexor tendon repair.
Reducing ambulatory central line‐associated bloodstream infections: A family‐centered approach
Authors: Wong Chris I. , Ilowite Maya , Yan Adam , Mahan Riley M. , Desrochers Marie D. , Conway Margaret , Billett Amy L. 
Published: May 2024

AbstractBackgroundAmbulatory central line‐associated bloodstream infections (CLABSIs) cause significant morbidity and mortality, especially in pediatric oncology. Few studies have had interventions directed toward caregivers managing central lines (CL) at home to reduce ambulatory CLABSI rates. We aimed to reduce and sustain our ambulatory CLABSI rate by 25% within 3 years of the start of a quality improvement intervention.ProcedurePlan‐do‐study‐act cycles were implemented beginning April 2016. The main intervention was a family‐centered CL care skill development curriculum for external CLs. Training began upon hospital CL insertion, followed by an ambulatory teach‐back program to achieve home caregiver CL care independence. Other changes included: standardizing ambulatory nurse CL care practice (audits, a train the nurse trainer process, and workshops for independent home care agencies); developing aids for trainers and caregivers; providing supplies for clean surfaces; wide dissemination of the program; and minimizing opportunities of CLABSI (e.g., standardizing timing of CL removal). The outcome measure was the ambulatory CLABSI rate (excluding mucosal barrier injury laboratory‐confirmed bloodstream infection), compared pre intervention (January 2015 to March 2016) to post intervention, including 2 years of sustainability (April 2016 to June 2023), using statistical process control charts. We estimated the total number of CLABSI and associated healthcare charges prevented.ResultsThe ambulatory CLABSI rate decreased by 52% from 0.25 to 0.12 per 1000 CL days post intervention, achieved within 27 months; 117 CLABSI were prevented, with $4.2 million hospital charges and 702 hospital days avoided.ConclusionsFocusing efforts on home caregivers CL care may lead to reduction in pediatric oncology ambulatory CLABSI rates.
Diketopyrrolopyrrole‐Dioxo‐Benzodithiophene‐Based Multifunctional Conjugated Polymers for Organic Field‐Effect Transistors and Perovskite Solar Cells
Authors: Kranthiraja Kakaraparthi , He Waner , Yu Hao‐Wei , Feng Zhen , Nozaki Naoya , Matsumoto Hidetoshi , Yu Ming‐Hsuan , Li Yong , Manzhos Sergei , Andersson Mats R. , Chueh Chu‐Chen , Michinobu Tsuyoshi , Sonar Prashant 
Published: May 2024

While dual‐acceptor‐type conjugated polymers have witnessed a great success in organic field‐effect transistors (OFETs), their potential multifunctionality in other optoelectronic devices has been overlooked. Herein, three conjugated polymers (DPPF‐BDD, DPPT‐BDD, and DPPSe‐BDD) comprising furan/thiophene/selenophene‐flanked diketopyrrolopyrrole (DPP) and dioxo‐benzodithiophene (BDD) as repeating units are designed, synthesized, and characterized. Modulating the chalcogen on DPP flank shows an impact on dual‐acceptor polymer optoelectronic properties. Subsequently, the potential of these polymers in both OFETs and perovskite solar cells (PSCs) either as semiconductors or as passivation materials, respectively, is investigated. Interestingly, DPPF‐BDD, DPPT‐BDD, and DPPSe‐BDD show ambipolar behavior in vacuum with hole (μh) and electron (μe) mobilities of 0.0263/0.0223, 0.0187/0.0123, and 0.0070/0.0051 cm2 V−1 s−1, respectively. Upon doping tetrabutylammonium iodide into DPPF‐BDD, DPPT‐BDD, and DPPSe‐BDD polymers, the respective OFETs show relatively higher μh and μe (0.0389/0.0503; 0.0289/0.0259; 0.0058/0.0156 cm2 V−1 s−1) than the undoped polymer OFETs. Furthermore, DPPF‐BDD‐, DPPT‐BDD‐, and DPPSe‐BDD‐incorporated (in the antisolvent treatment and PCBM electron transport layer) PSCs display maximum power conversion efficiency of 23.48%, 22.85%, and 23.35%, respectively, surpassing the control device (22.83%), which is benefited from the perovskite surface passivation and the charge extraction improvement. Overall, a new class of multifunctional DPP‐based dual‐acceptor‐type polymers that are highly compatible with OFETs and high‐performance PSCs is presented.
Anwendung der extra- und intracochleären Elektrocochleographie während und nach der Cochleaimplantation
Authors: Dalbert Adrian , Weder Stefan 
Published: May 2024

ZusammenfassungDie Elektrocochleographie (ECochG) bietet eine aussichtsreiche Möglichkeit zur Überwachung der cochleären Funktion während der Cochleaimplantation und zur Erforschung der Ursachen des Verlusts cochleärer Restfunktion nach der Implantation. Die vorliegende Arbeit gibt einen Überblick über den aktuellen Forschungs- und Anwendungsstand der ECochG, sowohl während als auch nach der Cochleaimplantation. Die intraoperative ECochG kann entweder durch das Implantat selbst oder mittels einer extracochleären Messelektrode durchgeführt werden. Postoperative ECochG-Aufnahmen sind über das Implantat möglich. Verschiedene Studien haben gezeigt, dass ein signifikanter Abfall der ECochG-Amplitude während der Elektrodeninsertion mit einem erhöhten Risiko für den Verlust der cochleären Restfunktion korreliert, wobei bedeutsame cochleäre Ereignisse vornehmlich gegen Ende der Insertion auftreten. Postoperative Daten deuten darauf hin, dass der Verlust der cochleären Funktion hauptsächlich in der frühen postoperativen Phase erfolgt. Zukünftige Forschungsansätze umfassen die Automatisierung und Objektivierung der Signalauswertung sowie eine vertiefte Untersuchung der den Signaländerungen zugrunde liegenden Mechanismen.
Evaluating the use of marine subsidies by Arctic foxes without direct coastal access; insights from stable isotopes
Authors: Angerbjörn Anders , Lidén Kerstin , Roth James D. , Dalerum Fredrik 
Published: May 2024

AbstractThe trophic structures of tundra ecosystems are often viewed as a result of local terrestrial primary productivity. However, other resources can be brought in through long-distant migrants or be directly accessible in coastal areas. Hence, trophic structures may deviate from predictions based on local terrestrial resources. The Arctic fox (Vulpes lagopus) is a small canid that may use marine resources when available. We used stable isotope values in Arctic fox fur and literature data on potential prey to evaluate Arctic fox summer resource use in a mountain tundra without coastal access. The dietary contribution of local prey, presumably mostly rodents, declined with declining rodent abundance, with a subsequent increased contribution of migratory prey relying on marine resources. Stable isotope values did not differ between this terrestrial area and an area with direct coastal access during years of high rodent abundance, but isotope values during low rodent abundances suggested less marine input than in a coastal population feeding primarily on marine prey. Our study shows that marine resources may be used by animals in areas without any coastal access, and we highlight that such partial coupling of ecosystems must be included in the modeling and assessments of tundra environments.