bluuebunny/crossref_metadata_2025_split huggingface dataset:
How Reasons-Focused Is the Categorical Imperative?
Authors: Schumski Irina 
Published: May 2024

AbstractAccording to Pauline Kleingeld’s account of Kant’s prohibition on using others merely as means, A uses B merely as a means if and only if (1) A uses B as a means in the service of realizing her ends, (2) without, as a matter of moral principle, making this use conditional on B’s consent, where (3) by “consent” is meant B’s genuine actual consent to being used, in a particular manner, as a means to A’s end. I suggest that there are two readings of what I refer to as her account’s “double reasons-focus”: whether A uses B merely as a means is either partly or fully determined by A’s reasons (moderate or radical reasons-focus in the criterion sense) and A’s reasons are either part of what the prohibition assesses or the only thing it assesses (moderate or radical reasons-focus in the object-of-assessment sense). I then argue that while it is unusual to interpret Kant’s prohibition as radically reasons-focused in both these senses, doing so is far from unmotivated and might constitute a fruitful move in the debate on the Categorical Imperative. I conclude by showing that this move would allow Kleingeld to dismiss what might otherwise seem like a problem for her account, namely that it cannot accommodate the possibility of non-instrumentalizing violations of perfect duty.
C-terminal frameshift mutations generate viable knockout mutants with developmental defects for three essential protein kinases
Authors: Zhang Yun , Cui Miao-Miao , Ke Run-Nan , Chen Yue-Dan , Xie Kabin 
Published: May 2024

AbstractLoss-of-function mutants are fundamental resources for gene function studies. However, it is difficult to generate viable and heritable knockout mutants for essential genes. Here, we show that targeted editing of the C-terminal sequence of the embryo lethal gene MITOGEN-ACTIVATED PROTEIN KINASES 1 (OsMPK1) results in weak mutants. This C-terminal-edited osmpk1 mutants displayed severe developmental defects and altered disease resistance but generated tens of viable seeds that inherited the mutations. Using the same C-terminal editing approach, we also obtained viable mutants for a wall-associated protein kinase (Os07g0493200) and a leucine-rich repeat receptor-like protein kinase (Os01g0239700), while the null mutations of these genes were lethal. These data suggest that protein kinase activity could be reduced by introducing frameshift mutations adjacent to the C-terminus, which could generate valuable resources for gene function studies and tune protein kinase activity for signaling pathway engineering.
The prospects of using AI in euthanasia and physician-assisted suicide: a legal exploration
Authors: van Kolfschooten Hannah 
Published: May 2024

AbstractThe Netherlands was the first country to legalize euthanasia and physician-assisted suicide. This paper offers a first legal perspective on the prospects of using AI in the Dutch practice of euthanasia and physician-assisted suicide. It responds to the Regional Euthanasia Review Committees’ interest in exploring technological solutions to improve current procedures. The specific characteristics of AI – the capability to process enormous amounts of data in a short amount of time and generate new insights in individual cases – may for example alleviate the increased workload of review committees due to the continuous increase of euthanasia cases. The paper considers three broad categories for the use of AI in the Dutch euthanasia practice: (1) the physician’s assessment of euthanasia requests, (2) the actual execution of euthanasia, and (3) the retrospective reviews of cases by the Regional Euthanasia Review Committees. Exploring the legal considerations around each avenue, both in the EU AI Act and the Dutch legal framework, this paper aims to facilitate the societal discussion on the role of technology in such deeply human decisions. This debate is equally relevant to other countries that legalized euthanasia (e.g. Belgium and Canada) or physician-assisted suicide (e.g. Switzerland and numerous states in the US).
Reducing organizational inequalities associated with algorithmic controls
Authors: Li Yueqi , Xiang Biyun 
Published: May 2024

AbstractAlgorithmic technologies are widely applied in organizational decision-making today, which can improve resource allocation and decision-making coordination to facilitate the accuracy and efficiency of the decision-making process within and across organizations. However, algorithmic controls also introduce and amplify organizational inequalities—workers who are female, people of color and the marginalized population, and workers with low skills, a low level of education, or who have low technology literacy can be disadvantaged and discriminated against due to the lack of transparency, explainability, objectivity, and accountability in these algorithms. Through a systematic literature review, this study comprehensively compares three different types of controls in organizations: technical controls, bureaucratic controls, and algorithmic controls, which led to our understanding of the advantages and disadvantages associated with algorithmic controls. The literature on the organizational inequality related to the employment of algorithmic controls is then discussed and summarized. Finally, we explore the potential of trustworthy algorithmic controls and participatory development of algorithms to mitigate organizational inequalities associated with algorithmic controls. Our findings raise the awareness related to the potential corporate inequalities associated with algorithmic controls in organizations and endorse the development of future generations of hiring and employment algorithms through trustworthy and participatory approaches.
The Clinical Gaze of Lurianic Kabbalah
Authors: Tamari Assaf 
Published: May 2024

AbstractWhat changes in the conceptualization of God, the ultimate healer, once God himself becomes the object of healing? This article examines the delicate tensions between divine and human agency in the Lurianic kabbalah, focusing on its grammar of action, and the complex relations between the subjects and the objects of this action. Rather than analyzing the relations between the kabbalists and their God through their conscious perceptions, the article explores how these relations emerge from the Lurianic discursive configurations and describes the role of medical discourse in their shaping. I claim that in order to perceive the transformation in the image of God in this early modern kabbalistic corpus, we should place at the heart of our inquiry the questions of who the patient is in the Lurianic medical clinic and how the relations between the human and the divine protagonists of the Lurianic drama are woven in this clinic.
From modal collapse to moral collapse
Authors: Smith Drew 
Published: May 2024

Abstract
I aim in this article to contribute two points to the ongoing discussion regarding strong DDS and modal collapse. First, I will examine a recent version of the modal collapse objection formulated by R. T. Mullins, demonstrating that one can modify the argument to survive its most forceful rejoinder. Having established the cogency of Mullins's modal collapse argument, I next aim to heighten the severity of the conclusion. In particular, I demonstrate that the success of the modal collapse argument entails a moral collapse wherein well-established principles of ethical reasoning fail. Finally, I examine a recent attempt by Katherine Rogers to undercut some of the unwelcomed results of a modal collapse via an appeal to the theistic multiverse. I conclude that this manoeuvre proves ineffective against the moral collapse objection.
The effect of social support on the emotional well-being of people with amyotrophic lateral sclerosis: Exploring the mediating role of spirituality
Authors: Fernandez Anne , Guenegou Léo , Corcia Philippe , Bailly Nathalie 
Published: May 2024

AbstractObjectivesAmyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that, so far, is considered always fatal. Treatments mainly consist in increasing survival and aim to improve the quality of life of people with ALS (pwALS). Social support and spirituality have been shown to play a key role in pwALS’ quality of life. Our study explored it in depth by investigating the underlying mechanisms linking social support, spirituality, and emotional well-being.MethodsThirty-six pwALS underwent a battery of tests evaluating emotional well-being (emotional well-being scale of the 40-item Amyotrophic Lateral Sclerosis Assessment Questionnaire), social support (6-item Social Support Questionnaire), and spiritual well-being (12-item Functional Assessment of Chronic Illness Therapy – Spiritual well-being). Our recruitment was web-based through the FILSLAN and the ARSLA websites as well as through Facebook® advertisements (ALS groups). Data were analyzed by Pearson correlation analysis and Process macro was used in an SPSS program to analyze the mediator variable effect.ResultsAvailability of social support, spiritual well-being, and 2 of its dimensions, i.e., meaning and peace, were positively correlated with emotional well-being. The mediational analyses showed that spiritual well-being, meaning, and peace act as mediators in the association between availability of social support and good emotional well-being.Significance of resultsAvailability of social support and spirituality are essential for the emotional well-being of pwALS. Spirituality as a mediator between availability of social support and emotional well-being appears as real novel finding which could be explored further. Spiritual well-being, meaning, and peace appear as coping resources for pwALS. We provide practical guidance for professionals working with pwALS.
Validation of the Mexican version of the EORTC QLQ-CR29 in patients with colorectal cancer
Authors: Hernández-Marín Jazmín , Galindo-Vázquez Oscar , Calderillo-Ruíz German , Ortega-Andeane Patricia , Estapé Tania , Montero-Pardo Xolyanetzin , Ruíz-García Erika , Herrera-Martínez Marytere , Meneses-García Abelardo 
Published: May 2024

AbstractBackgroundThe evaluation of the quality of life (QoL) of patients with colorectal cancer (CRC) is an essential measure to measure the impact of the disease and treatments on the lives of patients. However, in Latin America there is no validated and reliable instrument to assess this construct.ObjectivesThis study aims to validate the EORTC QLQ-CR29 instrument in the Mexican population with CRC.MethodsThis study aims to validate the EORTC QLQ-CR29 instrument in the Mexican population with CRC. The study used an instrumental design and a nonprobabilistic sample due to availability, made up of 251 patients with CRC, with an average age of 54.7 ± 12.28 years. Exploratory and confirmatory factor analyses were performed, as well as concurrent validity tests.ResultsThe exploratory factorial analysis yielded 4 factors that explained 51.64% of the variance, with a Cronbach reliability coefficient of .766 and an Omega index of .725. The confirmatory factor analysis indicated that the proposed theoretical model fits the data almost perfectly, with an error close to 0, which shows that it is a balanced and parsimonious instrument to measure the QoL of the patients with CRC.Significance of resultsThe EORTC QLQ-CR29 instrument proved to be a valid and reliable instrument for use in clinical care and research directed at patients with CRC in Mexico. Its use is recommended by multidisciplinary health teams in oncology in Mexico, since it allows knowing the patient’s perspective on the impact of CRC on their life, guiding therapeutic decision-making and being a primary outcome measure.
The double burden of severe mental illness and cancer: a population-based study on colorectal cancer care pathways from screening to end-of-life care
Authors: Seppänen A.-V. , Daniel F. , Houzard S. , Le Bihan C. , Coldefy M. , Gandré C. 
Published: May 2024

Abstract

Aims
Cancer is one of the main causes of death in persons with severe mental illness (SMI). Although their cancer incidence is similar, or sometimes even potentially lower compared to the general population, their cancer mortality remains higher. The role of healthcare provision and care equity in this mortality is increasingly being addressed in research, but available studies are limited in their scope. In this context, our aim was to compare colorectal cancer (CRC) care pathways from screening to end-of-life care in patients with and without pre-existing SMI on a national scale.

Methods
This research leverages real-world data from the French national health claims database, covering the entire population, to assess cancer screening, diagnosis, treatment and post-treatment follow-up as well as quality of care (QOC) pathways among patients with incident CRC in 2015–2018, considering whether they had pre-existing SMI. We matched patients with SMI with three patients without – on age, sex, region of residence, year of cancer incidence and cancer type and location at presentation – as well as nationally established quality of CRC care indicators and regression models adjusting for relevant socio-economic, clinical and care provider-related covariates.

Results
Among patients with incident CRC, 1,532 individuals with pre-existing SMI were matched with individuals without SMI. After adjusting for covariates, both colon and rectal cancer patients with SMI were less likely to participate in the national CRC screening programme and to receive advanced diagnostic examinations (e.g., colonoscopies and several complementary diagnostic examinations). They also had lower odds of receiving combined treatments (e.g., neoadjuvant chemotherapy, radiotherapy and excision) and of having access to targeted therapy or capecitabine but higher odds for invasive care (e.g., stoma). Colon cancer patients with SMI were also more likely to have no treatment at all, and rectal cancer patients with SMI were less likely to receive post-treatment follow-up. Suboptimal QOC was observed for both groups of patients, but to a higher extent for patients with SMI, with statistically significant differences for indicators focusing on diagnosis and post-treatment follow-up.

Conclusions
Our findings reveal discrepancies across the care continuum of CRC between individuals with and without SMI and provide initial avenues on where to focus future efforts to address them, notably at the entry and exit stages of cancer care pathways, while calling for further research on the mechanisms preventing equity of physical healthcare for individuals with SMI.
Adaptation of Wind Drag Coefficient Parameterization: Improvement of Hydrodynamic Modeling by a Wave‐Dependent Cd in Large Shallow Lakes
Authors: Zhang Chen , Chen Lingwei , Brett Michael T. 
Published: May 2024

AbstractWind is a critical driving force in hydrodynamic and water quality modeling of large shallow lakes, and is characterized by the wind drag coefficient Cd, representing the momentum transfer at the air‐water interface. Contemporary empirical formulae for Cd estimation were derived over oceans and some of which are solely wind velocity U10 dependent. These formulae were previously found to be inadequate in inland lake models often resulting in the water velocity underestimation. To address this problem, a physical scale experiment was designed, in which Cd was measured using a wind profile and eddy covariance methodology. A new wind‐induced wave‐dependent Cd parameterization was also established and validated in two lake studies. The driving force was modified by the wave‐dependent Cd formula in a hydrodynamic model of the shallow Upper Klamath Lake (UKL), OR, USA. The experimental Cd was negatively correlated to the wind velocity up until the critical U10 = 1.6 m s−1 which was 1.0~3.1 times previous empirical extrapolations at light winds. The variation partitioning results showed that wave parameters contributed to more than 30% of Cd variation combined with wind parameters. The modified wind stress field was spatially heterogeneous and the modeled water velocity was closer to the observations at two sites. Significant main circulation and outer bank circulation were modeled accompanied by higher surface vorticity, compared to the original UKL model. Overall, the wave‐dependent Cd formula provided an improvement of the surface flow field in the UKL model and will improve the management of the lake ecosystems.
Interannual Variations in Spring Snowmelt Timing of Alaskan Black Spruce Forests Using a Bulk‐Surface Energy Balance Approach
Authors: Ikawa Hiroki , Nakai Taro , Busey Robert C. , Harazono Yoshinobu , Ikeda Kyoko , Iwata Hiroki , Nagano Hirohiko , Saito Kazuyuki , Ueyama Masahito , Kobayashi Hideki 
Published: May 2024

AbstractSpring snowmelt occurs for a short duration on an annual time scale, but their timings considerably affect the carbon and hydrological cycle in high‐latitude ecosystems. Here, we developed a simple snowmelt model, treating the ecosystem surface as a bulk‐surface layer. Energy fluxes across this bulk surface and the snow‐soil boundary determine snow temperature and the energy utilized for snowmelt. Parameterizing the bulk surface using decade‐long eddy covariance site data from two Alaskan open black spruce forests offered an opportunity to quantitatively evaluate meteorological drivers affecting snowmelt timings without the needs for detailed canopy information. The sensitivity analysis suggested that the total snowfall on the forest floor, ranging from 0.35 m in 2016 to about 1 m in 2018 and 2020, was the most crucial driver for snowmelt timing. This factor accounted for a 10‐day difference in the interannual variations in snow disappearance dates. The importance of the snowfall varied from year to year, and in 2013, the late snowmelt was characterized by low air temperatures, which increased sensible heat loss from the snowpack. The importance of atmospheric radiation was revealed in relatively warm years, such as 2016 and 2019. Our modeling approach necessitates adjusting one empirical parameter that reflects the heat conductivity from the bulk surface to the snow, based on observations. Nevertheless, despite this need for adjustment, the bulk‐surface approach helps identify important meteorological drivers underlying observed snowmelt within a simple theoretical framework.
Carbon Stocks and Fluxes From a Boreal Conifer Swamp: Filling a Knowledge Gap for Understanding the Boreal C Cycle
Authors: Davidson Scott J. , Davies Marissa A. , Wegener Emma , Claussen Sara , Schmidt Megan , Peacock Mike , Strack Maria 
Published: May 2024

AbstractThe carbon (C) dynamics of boreal coniferous swamps are a largely understudied component of wetland carbon cycling. We investigated the above‐ and below‐ground carbon stocks and growing season carbon dioxide (CO2) and methane (CH4) fluxes from a representative boreal coniferous swamp in northern Alberta, Canada in 2022. Tree inventories, understory vegetation biomass and peat cores were collected across three sub‐sites within the broader swamp, with gas flux collars placed in the dominant plant communities present. Alongside the C flux measurements, environmental variables such as water table depth, soil temperature and growing season understory green leaf phenology were measured. Our results show that these boreal coniferous swamps store large volumes of organic C in their biomass and soil (134 kg C m−2), comparable with other wetland and forest types, although 95% of the total C stock at our site was within the soil organic carbon. We also found that understory CO2 and CH4 fluxes indicated that the ground layer of the site is a source of greenhouse gases (GHGs) to the atmosphere across the growing season. However, we did not measure litterfall input, tree GHG fluxes or net primary productivity of the overstory, therefore we are not able to say whether the site is an overall source of C to the atmosphere. This study provides a much‐needed insight into the C dynamics of these under‐valued wetland ecosystems, and we highlight the need for a coordinated effort across boreal regions to try to improve inventories of C stocks and fluxes.
2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis
Authors: Peng Fu , Liao Minru , Jin Wenke , Liu Wei , Li Zixiang , Fan Zhichao , Zou Ling , Chen Siwei , Zhu Lingjuan , Zhao Qian , Zhan Gu , Ouyang Liang , Peng Cheng , Han Bo , Zhang Jin , Fu Leilei 
Published: May 2024

AbstractSirtuin 3 (SIRT3) is well known as a conserved nicotinamide adenine dinucleotide+ (NAD+)-dependent deacetylase located in the mitochondria that may regulate oxidative stress, catabolism and ATP production. Accumulating evidence has recently revealed that SIRT3 plays its critical roles in cardiac fibrosis, myocardial fibrosis and even heart failure (HF), through its deacetylation modifications. Accordingly, discovery of SIRT3 activators and elucidating their underlying mechanisms of HF should be urgently needed. Herein, we identified a new small-molecule activator of SIRT3 (named 2-APQC) by the structure-based drug designing strategy. 2-APQC was shown to alleviate isoproterenol (ISO)-induced cardiac hypertrophy and myocardial fibrosis in vitro and in vivo rat models. Importantly, in SIRT3 knockout mice, 2-APQC could not relieve HF, suggesting that 2-APQC is dependent on SIRT3 for its protective role. Mechanically, 2-APQC was found to inhibit the mammalian target of rapamycin (mTOR)-p70 ribosomal protein S6 kinase (p70S6K), c-jun N-terminal kinase (JNK) and transforming growth factor-β (TGF-β)/ small mother against decapentaplegic 3 (Smad3) pathways to improve ISO-induced cardiac hypertrophy and myocardial fibrosis. Based upon RNA-seq analyses, we demonstrated that SIRT3-pyrroline-5-carboxylate reductase 1 (PYCR1) axis was closely assoiated with HF. By activating PYCR1, 2-APQC was shown to enhance mitochondrial proline metabolism, inhibited reactive oxygen species (ROS)-p38 mitogen activated protein kinase (p38MAPK) pathway and thereby protecting against ISO-induced mitochondrialoxidative damage. Moreover, activation of SIRT3 by 2-APQC could facilitate AMP-activated protein kinase (AMPK)-Parkin axis to inhibit ISO-induced necrosis. Together, our results demonstrate that 2-APQC is a targeted SIRT3 activator that alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis, which may provide a new clue on exploiting a promising drug candidate for the future HF therapeutics.