bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D Two Phases Reduced Model of a Rock Bed Thermocline Thermal Energy Storage Unit: Parametric Study on Thermal Performances
Authors: Sougtan Yassine , Khalij Mohammed , El Qarnia Hamid , Kheiri Abdelhamid 
Published: February 2025

ABSTRACTA numerical simulation was conducted to evaluate the performance of a structured compact rock‐bed energy storage system. The study encompassed the analysis of various configurations of rock bed arrangements, including simple cubic, body‐centred cubic, and face‐centred cubic structures, along with their dimensions and the velocity of the heat transfer fluid (HTF) during the charging process. A transient three‐dimensional reduced model incorporating symmetry planes was developed and subsequently validated. This approach has been shown to significantly minimize the extensive computational time typically required when the full model is adopted, while providing enhanced accuracy compared to commonly used models in existing literature, achieving an improvement in accuracy exceeding 5%. Moreover, the methodology that has been adopted enables a more comprehensive investigation of the storage system, thus facilitating the capture of local data. The findings indicated a pronounced effect of the arrangement of the rock bed, the rock dimensions, and the HTF velocity on the heat transfer within the thermocline rock bed thermal energy storage system. It was determined that the thermal energy storage was optimized when the rocks were arranged in a face‐centered cubic configuration, which is associated with lower porosity. It was established that, at an HTF velocity of 3.84 × 10–4 m.s‐1 and a rock diameter of 0.01 m, transitioning from a simple cubic arrangement to a face‐centred cubic arrangement resulted in a 16.5% increase in capacity ratio and a 21.5% enhancement in exergy efficiency. Furthermore, it was determined that this transition also delayed the charging process by 39% (equivalent to 40 min). Moreover, a reduction in the rock diameter from 0.05 to 0.01 m resulted in a 44% increase in capacity ratio and a 54.5% rise in exergy efficiency for a simple cubic arrangement at the same HTF velocity, with a recorded 76% increase in charging duration. Furthermore, for a rock diameter of 0.03 m and a simple cubic arrangement, decreasing the HTF velocity from 9.233 × 10–4 m.s‐1 to 2 × 10–4 m.s‐1 resulted in a 26.5% increase in capacity ratio, a 28% increase in exergy efficiency, and a delay of 2.8 h in charging duration.
Impact Analysis of Combining Distributed Generation With Charging Loads for Electric Vehicles Accounting Reliability
Authors: Ahmed Khaliq , Sakravdia Devkaran , Sharma Chandrakant 
Published: February 2025

ABSTRACTThis work is concerned with the penetration of renewable energy‐based distributed generation along with electric vehicle (EV) charging loads into power distribution systems. This presents a new optimization procedure integrating Particle Swarm Optimization and the Andean Condor Algorithm (PSO‐ACA) into a high‐performing route for system design. It analyzes the performance of the system in terms of minimizing the loss of power and maximizing reliability. The study evaluates reliability indices and power loss reductions in detail by utilizing benchmark 33‐bus and 69‐bus test systems. The findings indicate that for the 33‐bus system, the active power loss reduction obtained is 64.3 KW, with real power loss showing a 68% reduction, whereas for the 69‐bus system, real power loss decrease is 72% (62.8 KW). This led to a substantial reduction in reliability indices thus enhancing the overall system performance as hybrid optimization techniques improved the reliability of the system remarkably. These results show the immense potential that advanced hybrid optimization approaches combined with reliability analyses have for delivering the economically viable, sustainable renewable energy systems of the future. This collaboration is in line with the larger objectives of promoting sustainable energy solutions and establishing a more resilient and efficient energy framework.
A Novel Approach to Driver Negligence Detection: EAXB‐EVS Algorithm With IoT Integration
Authors: S Bharathi , Durgadevi P. 
Published: February 2025

ABSTRACTIn recent days, road accidents have become a major issue, caused by negligence of the driver such as drowsiness, alcohol consumption during driving, gas leakage, tiredness, and traffic law violations. Timely decisions and accurate driver negligence detection are mandatory for avoiding road accidents and fatalities. However, the earlier research encountered various obstacles such as more energy consumption, poor detection performance, and required high computational time. This research proposes a novel Internet of Things‐based Ensemble‐voting Adaptive Extreme Boost‐based Energy Valley Search algorithm within the Vehicular Ad‐Hoc Networks environment for early and accurate detection of driver negligence. The proposed Ensemble‐voting Adaptive Extreme Boost‐based Energy Valley Search framework utilizes an Eye Aspect Ratio and Mouth Aspect Ratio analysis to identify the driver's facial contours like mouth and pupils by analyzing the imaging data. Further, the Ensemble‐voting Adaptive Extreme Boost model is employed for effective prediction of driver negligence that combines the weak learner models using ensemble voting and adapts dynamically for identifying the driver's state of carelessness including intoxication, gas leakage, and drowsiness. The hyperparameter of the Ensemble‐voting Adaptive Extreme Boost framework is fine‐tuned by applying Energy Valley Search, which enhances the accuracy and efficiency of the system while minimizing the computational overhead and energy consumption. The effectiveness of the proposed model is validated using some evaluation measures on three datasets namely, the Driver Inattention Detection Dataset, the India Road Accident Dataset, and the Driver Drowsiness Dataset. The simulation outcomes indicate that the Ensemble‐voting Adaptive Extreme Boost‐based Energy Valley Search framework attained a higher accuracy of 98.87%, less execution time of 1.03 s, and less energy usage of 5%, which makes the proposed system highly efficient for the real‐time vehicular network application.
Commodity Price Crash Risk and Crash Risk Contagion
Authors: Jain Prachi , Maitra Debasish 
Published: February 2025

ABSTRACTIn this study, we propose measures for the risk of commodity price crash. Building on the recent phenomenon of financialization of commodities, we advocate the use of down‐to‐up volatility (DUVOL) and a negative coefficient of skewness (NCSKEW) using 1‐min and daily data, respectively. We find that the crash risk is the highest for natural gas, sugar, and coffee and remains low to moderate for most precious metals. Subsequently, we explore the commodity‐specific drivers of crash risk upon controlling for macro‐economic variations. We find that speculation and hedging pressure exacerbate the crash risk of most commodities, whereas basis risk alleviates the crash risk of commodities. We document that crash risk is priced in the cross‐section of commodity returns. We also find that the crash risk spillovers are asymmetric, remaining low at 33% at the median and peaking at approximately 88% during the extremities.
Dissemination strategies of clinical practice guidelines—mixed methods evidence synthesis protocol
Authors: Nagraj Sumanth Kumbargere , Hafver Tandekile Lubelwana , Hohlfeld Ameer , Effa Emmanuel , Mabetha Denny , Kunje Gertrude , Shen Yan Jiao , Zaror Carlos , Lakudzala Suzgika , Mpando Talitha , van de Velde Stijn , Agoritsas Thomas , Delvaux Nicolas , Vandvik Per Olav 
Published: February 2025

AbstractClinical practice guidelines (CPGs) are shared through various dissemination strategies using a range of dissemination products and channels. However, users may have different needs for accessing and understanding them. Patients and carers from low‐ and middle‐income countries might face challenges in accessing CPGs such as inadequate systems for printed book distribution and insufficient and substandard photocopies. Many organizations offer lengthy documents, but busy healthcare workers may prefer shorter, digital versions. Digital CPGs can be sent through different channels such as email, newsletters, or social media. How users feel about these products (e.g., clinical protocol, educational material or decision aids) and how it affects the usage of CPGs is not well understood. In addition to these issues, most of the previous systematic reviews on this topic have clubbed the dissemination strategies along with the adoption of recommendations or implementation aspects. There is a need for evidence on the existing dissemination strategies disentangled from the implementation aspects. We aim to conduct a mixed‐methods systematic review to identify documented dissemination strategies for CPGs, barriers and facilitators to access such strategies and the expectations and needs of end users regarding dissemination needs. We will search literature from MEDLINE, Embase, CINAHL, Web of Science, Scopus, Epistemonikos, Agency for Healthcare Research and Quality and Medical Guidelines Clearing house. We will critically appraise all the included studies using appropriate tools based on the study design. We will use manifest content analysis to identify documented dissemination strategies and latent content analysis to understand the barriers, facilitators, preferences of end‐users. We intend to follow the convergent matrix model approach for this mixed methods evidence synthesis. We anticipate that this mixed‐methods systematic review will highlight the various strategies of dissemination of CPGs and the associated barriers and facilitators.
Lipoblastoma‐Like Tumor of the Tongue With IDH1 Mutation: A Case Report and Literature Review
Authors: Li Dongpo , Li Guangqi , Wang Ye , Shi Hailei , Wang Shuangyi , Zhan Xiaohong 
Published: February 2025

ABSTRACTBackgroundLipoblastoma‐like tumors (LLTs) are uncommon lipogenic neoplasms that predominantly occur in the vulva of female individuals. This study presents a novel case of LLT located on the tongue with an IDH1 mutation. Both the site of occurrence and molecular alterations are reported for the first time.Case PresentationA 65‐year‐old female patient presented to the hospital 1 month ago with an incidental finding of a multinodular mass at the right lingual margin. We performed an incision along the outer edge of the mass and completely excised it 0.5 cm beyond its periphery. The final pathological diagnosis after routine examination confirmed a lipoblastoma‐like tumor. Furthermore, Next‐generation sequencing revealed the presence of mutations in IDH1.ConclusionsThis study presents the first documented case of LLT, thereby expanding its anatomical site of tongue and confirming the presence of a significant IDH1 mutation, thus enhancing our understanding of the molecular alterations in LLT.
The Investigation of the Distribution of ABO/Rh Blood Group in Hospitalized COVID‐19 Patients and Its Association With Disease Severity, Clinical Outcomes, Lab Tests, and Radiologic Findings
Authors: Zendehdel Abolfazl , Asoodeh Azadeh , Ansari Mohsen , JamaliMoghaddamsiyahkali SaeidReza 
Published: February 2025

ABSTRACTBackground and Aimsit is important to identify patients at higher risk for severity and poor outcomes of COVID‐19 infection, to have better disease management and pandemic control. In this study, we aimed to assess the distribution of ABO and Rh blood groups in hospitalized COVID‐19 infected patients and demonstrate its association with severity and outcomes of the disease.MethodsThis is a cross‐sectional study at Ziaeian Specialist Hospital, in Tehran, Iran. Of all confirmed COVID‐19 infected patients who were admitted to this hospital, 273 patients were enrolled in this study and categorized based on their disease severity or clinical outcomes including intensive care unit (ICU) admission, need for mechanical ventilation and mortality. The distribution of ABO and Rh blood groups was assessed and compared between different groups, to investigate the association of blood group types with disease severity or outcomes. Also, the study population was categorized based on their blood group types to demonstrate the association of laboratory parameters, radiologic findings, and length of hospitalization with blood groups. Sex, age and underlying disease were adjusted in the final model by multivariate regression analysis.ResultsThis study showed that Blood group A (35.9%) was the most prevalent among hospitalized COVID‐19 patients followed by O (34.8%), B (21.6%), and AB (7.7%) (A > O > B > AB). ABO and Rh blood group was not associated with disease severity, need for mechanical ventilation, or ICU admission, while blood group B was associated with an increased risk of death in comparison with type O, in hospitalized COVID‐19 patients (p = 0.02). The number of patients with severe levels of C‐reactive protein (CRP) test results was lower in O blood group patients in comparison with non‐O blood groups (p = 0.01).ConclusionNo significant association was found between blood groups and other lab tests, radiologic findings, and length of hospitalization.
Addressing the Alarming Rise in Pediatric Cancer Prevalence in India: A Call to Action
Authors: Pathan Sohilkhan Riyazkhan , Bhende Vishal Vinayak , Sharma Kruti Bharat , Chowdappa Raghunandan Gorantlu , Patel Vishal Ajit , Gangoda Dinesh Maknya , Sharma Tanishq Shashikant 
Published: February 2025

ABSTRACTBackgroundChildhood cancer has become a pressing global concern, impacting over 200,000 children annually, and is projected to escalate to 21 million diagnoses by 2030. This article discusses the growing incidence of pediatric cancer in India, describes the unique obstacles it faces, and encompasses a strategy for solving this pressing problem.MethodsWe reviewed published scientific literature and available information on cancer control and prevention programs in India.ResultsAccording to the National Cancer Registry Programme, in India, childhood cancers (0−14 years) constitute 4.0% of all cancer cases. The surge in childhood cancer cases in India mirrors a global trend, emphasizing the necessity for a comprehensive understanding of contributing factors. Pediatric oncology in India faces challenges arising from limited rural healthcare access, resulting in delayed diagnosis and treatment. Socioeconomic factors hinder specialized pediatric cancer care, accentuating the need to bridge these gaps through targeted interventions, improved infrastructure, and policies. Additionally, there are limited population‐level epidemiologic studies on environmental, lifestyle, and genetic risk factors and childhood cancers. Research on genetic and environmental determinants is crucial for developing effective treatments. Addressing this requires public education, enhanced medical and research training, community‐based cancer screening, and integrated medical care initiatives. Advocacy and awareness campaigns play a vital role in tackling pediatric cancer challenges, supported by grassroots initiatives and collaboration between the government and nongovernmental organizations.ConclusionDespite recent efforts by the Ministry of Health, Government of India, childhood cancer lacks a specific policy in India. Urgent collective efforts are needed to address challenges, invest in research, enhance awareness, and advocate for policy changes. It is time for healthcare professionals, policymakers, researchers, and the public to collaborate and ensure no child in India is left behind in the fight against pediatric cancer, paving the way for a healthier future for the nation's youngest members.
Addressing the Health Needs of Refugees and Migrants in Türkiye: A Literature Review
Authors: Uwishema Olivier , Kwan Su Huey Alicia , Sengar Aman Singh , Patel Raj Pravin , Kazan Zeinab , Choudhary Karan 
Published: February 2025

ABSTRACTBackground and AimsAlthough every human has the right to overall well‐being, refugees worldwide often sustain inadequate healthcare. Türkiye, hosting a large refugee population, raises public concerns about providing equitable healthcare. This study aims to evaluate the Turkish healthcare system's effectiveness and limitations in addressing refugee health needs, identify challenges in accessing care, assess the impact of policies, and propose recommendations for improving refugee life quality.MethodsWe conducted a comprehensive review of the literature using databases like PubMed, MEDLINE, ScienceDirect, and Google Scholar. Our search focused on refugees impacted by recent crises and relevant policies. Keywords included “Refugee population in Türkiye,” “Barriers to accessing healthcare,” and “Turkish healthcare system.” We included English‐language articles relevant to our research objectives and empirical data, excluding studies not focused on refugees or migrants in Türkiye, and those published before 2010.ResultsThe review emphasizes the ongoing disparities in healthcare access for refugees in Türkiye. Despite significant efforts, barriers such as the locations of refugee camps, legal restrictions, and language differences continue to hinder healthcare access. Moreover, the sheer number of refugees exacerbates these issues. The recommendations focus on addressing these issues, ensuring better healthcare access, and improving refugee integration.ConclusionThe large influx of refugees into Türkiye has led to an unequal distribution of resources, creating substantial challenges in providing equitable healthcare. Chronic conditions and mental health disorders among refugees further highlight these issues. This underscores the need for international policy improvements, legal reforms, innovative solutions like telemedicine, and a more comprehensive healthcare approach to support refugees. Reducing social stigma and improving refugee integration into the healthcare system is crucial for achieving better health outcomes.
Competing Risks and Their Impact on Treatment Efficacy Assessment in Fractionated Stereotactic Radiotherapy for Brain Metastases: A Retrospective Study
Authors: Gruber Isabella , Koelbl Oliver 
Published: February 2025

ABSTRACTBackground and AimsThe Kaplan‐Meier (KM) method and competing risk analysis are two statistical approaches for analyzing time‐to‐event data. These methods differ in their treatment of competing events, such as deaths occurring before the event of interest, which can impact the interpretation of treatment efficacy in oncology.MethodsThis retrospective study included 73 patients who underwent fractionated stereotactic radiotherapy (six fractions of 5 Gy) for brain metastases at the University Hospital Regensburg between January 2017 and December 2021. The events of interest were the cumulative incidences of local failure within the planning target volume and the development of new brain metastases. Premature deaths occurring before the events of interest were treated as competing events. The complement of the KM method (1‐KM), which censors patients who die prematurely, was compared to the cumulative incidence function (CIF), which accounts for the fact that patients who die without experiencing the event of interest are no longer at risk for that event.ResultsThe median follow‐up was 56 months. The most common cancer types were non‐small cell lung cancer (n = 26, 35.6%) and malignant melanoma (n = 25, 34.2%). Using CIF, the cumulative incidences of local failure and new brain metastases were 27% and 55% at 24 months, respectively. The 1‐KM method overestimated the cumulative incidence of local failure by 9% at 24 months and 14% at 36 months, and new brain metastases by 13% at both 24 and 36 months. Survival curves for 1‐KM and CIF showed simultaneous increases for each event, with 1‐KM consistently higher, reflecting differing approaches to competing risks.ConclusionThis study highlights the impact of statistical method selection on clinical data interpretation and underscores the bias inherent in studies that fail to account for competing risks. Recognizing these differences is crucial for accurately assessing treatment outcomes.
Cordycepin mediates neuroprotection against apoptosis via ERK/CREB signaling activation in Aβ1–42‐induced neuronal cell models
Authors: Zhou Wenshu , Wang Cheng , Tan Yige , Lazarovici Philip , Wen Xiaoyan , Li Shaoping , Zheng Wenhua 
Published: February 2025

AbstractThe aggregation of β‐amyloid (Aβ) peptides has been associated with the onset of Alzheimer's disease (AD) by causing neurotoxicity due to oxidative stress and apoptosis. Cordycepin is a natural derivative of the nucleoside adenosine that displays potent antioxidant, antitumor, anti‐inflammatory, and neuroprotective properties. However, the mechanism of the neuroprotective effect of cordycepin toward Aβ‐induced neurotoxicity, as well as underlying mechanisms, is still unclear. In this study, we found that cordycepin conferred neuroprotection to catecholaminergic PC12 neuronal cell cultures exposed to Aβ1–42‐insult by reducing the production of reactive oxygen species, restoring the mitochondrial membrane potential, and inhibiting apoptosis. Cordycepin stimulated the phosphorylation of extracellular signal‐regulated kinase (ERK) and cyclic AMP‐responsive element‐binding protein (CREB) in a time‐ and concentration‐dependent manner. Inhibition of the ERK pathway reduced the neuroprotective effect of cordycepin. Similar results were obtained with hippocampal HT22 neuronal cell cultures. Cumulatively, these findings suggest that cordycepin‐induced neuroprotection toward Aβ1–42 neurotoxic insult may involve activation of the ERK/CREB pathway. This study expands our knowledge of the neuroprotective function of cordycepin and suggests that it holds promise as a natural lead compound for drug development in AD.
Approach to evaluation and management of male infertility in Sub‐Saharan Africa
Authors: Muteshi Charles , Chesire Albert 
Published: February 2025

AbstractThe prevalence of infertility among couples globally is estimated at 15%. Male factor infertility contributes to 20%–70% of the cases depending on the specific region of the world. Male infertility accounts for up to 22.26% of cases in Africa. Causes are generally categorized as pre‐testicular, testicular, or post‐testicular, based on the level of dysfunction within the hypothalamic–pituitary–gonadal axis. Primary testicular failure is caused by intrinsic testicular dysfunction, while secondary testicular failure originates from a dysfunction in the hypothalamus or the pituitary gland. Post‐testicular causes are attributed to obstructive, ejaculatory, or erectile dysfunction. Evaluation should thus entail a full history followed by a detailed physical exam and stepwise investigation. Semen analysis is recommended as the initial test, followed by hormonal tests, imaging, biopsies, and karyotyping as needed. Treatment is tailored based on the specific cause identified.