bluuebunny/crossref_metadata_2025_split huggingface dataset:
Public recognition of mental disorders and beliefs about treatment: changes in Australia over 16 years
Authors: Reavley Nicola J. , Jorm Anthony F. 
Published: March 2012

BackgroundA 1995 Australian national survey of mental health literacy showed poor recognition of disorders and beliefs about treatment that differed from those of health professionals. A similar survey carried out in 2003/4 showed some improvements over 8 years.AimsTo investigate whether recognition of mental disorders and beliefs about treatment have changed over a 16-year period.MethodA national survey of 6019 adults was carried out in 2011 using the same questions as the 1995 and 2003/4 surveys.ResultsResults showed improved recognition of depression and more positive ratings for a range of interventions, including help from mental health professionals and antidepressants.ConclusionsAlthough beliefs about effective medications and interventions have moved closer to those of health professionals since the previous surveys, there is still potential for mental health literacy gains in the areas of recognition and treatment beliefs for mental disorders. This is particularly the case for schizophrenia.
Intrahepatic Insulin Exposure, Intrahepatocellular Lipid and Regional Body Fat in Nonalcoholic Fatty Liver Disease
Authors: Mehta Sanjeev R. , Godsland Ian F. , Thomas E. Louise , Pavitt Darrell V. , Morin Stanislas X. , Bell Jimmy D. , Taylor-Robinson Simon D. , Johnston Desmond G. 
Published: March 2012

Context:
Insulin is pivotal in regulating hepatic lipid synthesis, metabolism, and export.

Objective:
We tested the hypothesis that intrahepatic insulin exposure is an important determinant of intrahepatocellular lipid (IHCL), taking into account regional adiposity and both glucoregulatory and antilipolytic insulin sensitivity.

Research Design and Methods:
We compared 21 European males with known nonalcoholic fatty liver disease (NAFLD) with 19 healthy male controls. Insulin sensitivity, secretion, and percentage hepatic extraction were derived from iv glucose tolerance test (IVGTT) glucose, insulin, and C-peptide concentrations. Intrahepatic insulin exposure was calculated as percentage hepatic insulin extraction multiplied by basal or IVGTT insulin secretion. IHCL was quantified by proton magnetic resonance spectroscopy. Total and regional adipose tissue was measured using whole body magnetic resonance imaging.

Results:
Percentage hepatic extraction of newly secreted insulin differed between cases with NAFLD and controls at borderline significance (median, 76 vs. 83%; P = 0.07). Cases had higher intrahepatic insulin exposure than controls, both in the basal (34 vs. 18 pmol; P = 0.0002) and glucose-stimulated states (58 vs. 24 pmol; P = 0.01). IHCL was significantly related to both basal (rs = 0.62; P &lt; 0.0001) and IVGTT intrahepatic insulin exposure (rs = 0.47; P = 0.002). As predictors of IHCL, both basal and IVGTT intrahepatic insulin exposure were dependent on the waist-to-hip ratio and homeostasis model assessment insulin resistance, but not on magnetic resonance imaging fat measures or IVGTT insulin sensitivity.

Conclusions:
Men with NAFLD have higher intrahepatic insulin exposure than controls. This correlates with IHCL, but the principal determinants of IHCL were fat distribution and hepatic rather than peripheral insulin resistance.
Functional comparison of protein domains within aPKCs involved in nucleocytoplasmic shuttling
Authors: Seidl Sebastian , Braun Ursula B. , Leitges Michael 
Published: March 2012

Summary
The atypical protein kinases C (PKC) isoforms ι and ζ play crucial roles in regulation of signaling pathways related to proliferation, differentiation and cell survival. Over the years several interaction partners and phosphorylation targets have been identified. However, little is known about the regulation of atypical aPKC isoforms. To address this question, we performed a comparative analysis of atypical aPKCι/λ and ζ in MDCK cells. By using green fluorescence protein (GFP) fusion proteins containing the full-length or truncated proteins, we were able to recognize differences in subcellular localization and nucleocytoplasmic shuttling of both isoforms. We show, that an earlier described nuclear localization sequence (NLS), plays a role in the regulation of atypical aPKCζ but not in aPKCι, despite the fact that it is present in both isoforms. Leptomycin B treatment induces accumulation of GFP-fusion protein of both isoforms in the nucleus. Regardless, the loss of the NLS only decreases shuttling of aPKCζ, while aPKCι remains unaffected. In addition, we identified the hinge region as a potential regulator of localization of atypical PKCs. With a set of chimeric proteins we show that the hinge region of aPKCι mediates nuclear localization. In contrast, the hinge region of aPKCζ causes exclusion from the nucleus, indicating two different mechanisms leading to isoform specific regulation. Taken together, we show for the first time, that the atypical isoforms aPKCι and ζ underly different mechanisms regarding their regulation of subcellular localization and translocation into the nucleus in MDCK cells.
Neopterin, inflammation-associated product, prolongs erythropoiesis suppression in aged SAMP1 mice due to senescent stromal-cell impairment
Authors: Aisaki Kazuo , Tsuboi Isao , Harada Tomonori , Oshima Hideki , Yamashita Akiko , Hirabayashi Yoko , Kanno Jun , Inoue Tohru , Aizawa Shin 
Published: March 2012

Anemia induced by inflammation is well known to be more serious in the elderly than in non-elderly adults; however, the reason why this is so remains unclear. Neopterin produced by monocytes during inflammation promotes myelopoiesis but suppresses B-lymphopoiesis and erythropoiesis, by activating stromal cells in mice. Here, age-related changes in the erythropoietic response to neopterin were determined using senescence accelerated mice (SAMP1) with senescence stromal-cell impairment. Intravenous injection of neopterin into young mice (8–12 weeks old) resulted in a decrease in erythroid progenitor cell number in the bone marrow (BM), concomitant with an increase in myeloid progenitor cell number over one week. Intravenous injection of neopterin into aged mice (30–36 weeks old) resulted in a prolonged decrease in erythroid progenitor cell number in the BM over three weeks and a limited increase in myeloid progenitor cell number over one day. Neopterin treatment induced a decrease in serum erythropoietin concentrations in young mice but not in aged mice. The gene expression of tumor necrosis factor α (TNF- α), a negative regulator of erythropoiesis, was up-regulated in the BM of both young and aged mice, and the degree of TNF- α up-regulation was the same in both groups. The gene expression of interleukin (IL)-11, a positive regulator of erythropoiesis, was also up-regulated over one day in both young and aged mice. However, IL-11 gene expression remained up-regulated thereafter in young mice, whereas it was rapidly down-regulated in aged mice. These data suggest that prolonged suppression of erythropoiesis in aged mice may be due to a decrease in the production of positive regulators rather than to an increase in the production of negative regulators. Our combined data suggest that age-related impairment of stromal cells induces serious anemia in the elderly during inflammation.
Clinical Results after Coil Embolization of the Ovarian Vein in Patients with Primary and Recurrent Lower-Limb Varices with Respect to Vulval Varices
Authors: Castenmiller P H , De Leur K , De Jong T E A M , Van Der Laan L 
Published: March 2012

Objective: To study the effect of coil embolization of the insufficient ovarian vein (IOV) on varices of the lower limb (VLL). Method: From December 2005 until May 2008, we selected all patients with phlebograms that were performed in our hospital to confirm the diagnosis of insufficiency of the ovarian vein. The CEAP (clinical, aetiological, anatomical and pathological elements) classification was used to classify the lower-limb venous disease in each patient. All patients with suspected IOV in combination with VLL underwent a phlebography. If IOV was found, coil embolization of the ovarian vein(s) was performed. Results: IOV was found in 43 of 44 patients (98%). After coil embolization of the ovarian vein(s), VLL disappeared in five patients (12%) without any further treatment. Improvement in CEAP classification was measured in 13 patients (31%). In 21 (88%) of 24 patients with vulval varices, coil embolization of the ovarian vein(s) resulted in disappearance of vulval varices. Conclusions: In only 31% of the patients with IOV in combination with VLL, phlebography and coil embolization of the ovarian vein(s) did improve CEAP classification. However, coil embolization of the ovarian vein resulted in disappearance of the vulval varices in 88% of the patients.
Low-dose estrogen combined oral contraceptives may negatively influence physiological bone mineral density acquisition during adolescence
Authors: Cibula David , Skrenkova Jana , Hill Martin , Stepan Jan J 
Published: March 2012

BackgroundThe aim was to evaluate changes of bone mineral density (BMD) and markers of bone turnover in healthy adolescents, and in adolescent users of combined oral contraceptives (COCs) with different ethinylestradiol (EE) contents.MethodsIn this prospective crossover study, 56 healthy females (15–19.5 years) with desire to use hormonal contraception were randomized to COC with either 30 or 15 μg of EE in crossover design of 9-month intervention each in reverse order. Nonusers of the same age (n=28) served as controls. BMD at lumbar spine (LS), total femur, femoral neck, distal radius, and total body, and serum markers (N-propeptide of type I procollagen, and type I collagen C-telopeptide) were measured at baseline and after 9 and 18 months.ResultsIn COC nonusers, BMD significantly increased at LS and radius, while markers decreased. In COC users, BMD did not increase, with the exception of LS BMD in the 30 μg COC group (P<0.05). In the crossover design, a difference between the low- and very low-dose COC users was found in LS BMD changes (P<0.05), where increase in BMD was more impaired in the 15 μg COC users. The skeletal effects of COC remained significant after adjustments for age and smoking status. Markers declined faster in COC users during the first period, while they remained stable or even increased during the second 9 months.ConclusionPhysiological acquisition of LS BMD during adolescent age may be prevented by use of COC, especially those containing very low dose of EE.
Nonchemical and Herbicide Treatments for Management of Japanese Stiltgrass (Microstegium vimineum)
Authors: Ward Jeffrey Stuart , Mervosh Todd L. 
Published: March 2012

AbstractJapanese stiltgrass, an annual grass species native to eastern Asia, has become a serious invasive-plant problem in the eastern United States. We compared the efficacy of herbicides and nonchemical options found effective for controlling stiltgrass in earlier studies, with organic herbicides and herbicides used at reduced rates in a wooded floodplain along the lower Connecticut River. We compared the effect of 2 yr of conventional and alternative treatments on cover of other nonnative and native species. Four blocks of 18 plots (3 by 4 m [9.8 by 13.1 ft]) were established in May 2008. Treatments included directed heating with a propane torch (June, July), hand-pulling (July), mowing with a string trimmer (July, August), foliar applications of household vinegar [5% acetic acid] (June, July) and the herbicides imazapic (June), pelargonic acid (June, July), and pelargonic acid plus pendimethalin (June). The following herbicides were applied at labeled doses and at one-fourth labeled doses: fenoxaprop-p-ethyl (July), glufosinate (August), and glyphosate (August). Stiltgrass cover and height were evaluated periodically, and plant samples were collected in autumn of 2008 and 2009 to determine the number of viable seeds produced. Final evaluations were conducted in June 2010 after 2 yr of treatment. Stiltgrass cover averaged 88% on untreated plots in fall. All treatments reduced stiltgrass cover and seed production. The least-effective treatments were hand-pulling, pelargonic acid, and vinegar in July. Direct heating, mowing, and vinegar in June reduced seed production by more than 90%. All treatments containing imazapic, pelargonic acid plus pendimethalin, fenoxaprop-p-ethyl, glufosinate, and glyphosate completely prevented stiltgrass seed production in the second year of treatment. Effective control of stiltgrass can be achieved during a 2-yr period with a variety of herbicides, including herbicides at one-fourth of the labeled dose, and through nonchemical treatments.
Competitive Interactions of Garlic Mustard (Alliaria petiolata) and Damesrocket (Hesperis matronalis)
Authors: Leicht-Young Stacey A. , Pavlovic Noel B. , Adams Jean V. 
Published: March 2012

AbstractCompetitive interactions between native plants and nonnative, invasive plant species have been extensively studied; however, within degraded landscapes, the effect of interspecific interactions among invasive plants is less explored. We investigated a competitive interaction between two sympatric, invasive mustard species that have similar life history strategies and growth forms: garlic mustard and damesrocket. Greenhouse experiments using a full range of reciprocal density ratios were conducted to investigate interspecific competition. Garlic mustard had a negative effect on the final biomass, number of leaves, and relative growth rate in height of damesrocket. Survival of damesrocket was not negatively affected by interspecific competition with garlic mustard; however, garlic mustard showed higher mortality because of intraspecific competition. These results indicated that although garlic mustard has been observed to be the dominant species in this landscape, it may not completely outcompete damesrocket in all situations. Studies of invasive species in competition are important in degraded landscapes because this is the common situation in many natural areas.
Nonchemical Methods for Paragrass (Urochloa mutica) Control
Authors: Chaudhari Sushila , Sellers Brent A. , Rockwood Stephen V. , Ferrell Jason A. , MacDonald Gregory E. , Kenworthy Kevin E. 
Published: March 2012

AbstractParagrass is a nonnative category I invasive species in central and south Florida. This perennial grass species outcompetes native vegetation and is capable of rapid spread by vegetative reproduction. Although glyphosate and imazapyr are effective herbicides for paragrass control, the use of herbicides in certain areas may be restricted because of application timing or environmental concerns. Therefore, our objectives were to examine the effect of water depth (saturated vs. flooded) after burning or cutting, and the effect of water depth and duration after simulated roller-chopping, on paragrass regrowth under controlled conditions. In the first study, paragrass plants were cut or burned with a propane burner to 1 cm (0.39 in) above the soil surface. Plants were either watered daily (control), or were subjected to one of two water treatments: water level at the soil surface (saturated) or flooded to a depth of 44 cm. Burned-saturated or burned-flooded plants had 92% less biomass 5 wk after treatment (WAT) than cut-saturated plants. Flooding resulted in plant death regardless of the plant treatment. In the second study, simulated roller-chopping was performed by cutting paragrass stolons into one-, two-, or three-node segments; planting them into flats; and subjecting them to water treatments for 3, 7, 14, 28, and 42 d. Burning, cutting, and roller-chopping could be useful to control paragrass if subsequent flooding is applied. Future research should focus on evaluating the response of these control techniques in natural areas where water depth can be managed.
Predicting the Occurrence of Downy Brome (Bromus tectorum) in Central Oregon
Authors: Lovtang Sara C. P. , Riegel Gregg M. 
Published: March 2012

AbstractWhere the nonnative annual grass downy brome proliferates, it has changed ecosystem processes, such as nutrient, energy, and water cycles; successional pathways; and fire regimes. The objective of this study was to develop a model that predicts the presence of downy brome in Central Oregon and to test whether high presence correlates with greater cover. Understory data from the U.S. Department of Agriculture (USDA) Forest Service's Current Vegetation Survey (CVS) database for the Deschutes National Forest, the Ochoco National Forest, and the Crooked River National Grassland were compiled, and the presence of downy brome was determined for 1,092 systematically located plots. Logistic regression techniques were used to develop models for predicting downy brome populations. For the landscape including the eastside of the Cascade Mountains to the northwestern edge of the Great Basin, the following were selected as the best predictors of downy brome: low average March precipitation, warm minimum May temperature, few total trees per acre, many western junipers per acre, and a short distance to nearest road. The concordance index = 0.92. Using the equation from logistic regression, a probability for downy brome infestation was calculated for each CVS plot. The plots were assigned to a plant association group (PAG), and the average probability was calculated for the PAGs in which the CVS plots were located. This method could be duplicated in other areas where vegetation inventories take place.
Biophysical Correlates with the Distribution of the Invasive Annual Red Brome (Bromus rubens) on a Mojave Desert Landscape
Authors: Abella Scott R. , Embrey Teague M. , Schmid Sarah M. , Prengaman Kathryn A. 
Published: March 2012

AbstractBecause of its ability to transform ecosystems by increasing the prevalence of fire, the invasive annual red brome is a priority exotic species for management in arid lands of the southwestern United States. By sampling red brome presence and 97 environmental (climatic, topographic, and soil) and native vegetation (e.g., perennial species richness) variables on 126 sites, we assessed biophysical correlates with red brome distribution on a 755,000-ha (1.9 million ac) Mojave Desert landscape. Brome occupied 55 of 126 (44%) 0.09-ha plots. The simplest models (i.e., those containing the fewest or most easily obtained variables) in multivariate (classification trees and nonparametric multiplicative regression) and univariate (χ2) models often portrayed red brome distribution as well, or nearly as well, as more complicated models containing more variables harder to obtain. The models varied, however, in their abilities for describing brome presence compared with absence. For example, a simple classification tree using only elevation, soil great group, parent material, and vegetation type improved estimates of brome presence for 55% of sites, absences for 87%, and overall for 73% of sites compared with a naïve model containing the observed frequency of brome in the data. Conversely, a more complicated model, including soil boron and sulfur, performed better for presences (96%) than for absences (73%; 83% overall). Results also showed variable support for two general postulates in invasive species science. Red brome distribution was not correlated with soil N, which is inconsistent with the supposition that nutrient-rich soils are more prone to invasion. Brome was correlated with native perennial species richness to support the postulate that exotic species abundance is correlated with species-rich habitats, but the correlation was weak (r= 0.38) and similar in strength to correlations with many other environmental variables. On this relatively low-elevation landscape, the areas currently most invaded by red brome include the higher elevations (> 777 m [2,549 ft]), limestone–sandstone soils, and burrobush and mixed perennial communities. Areas least inhabited by brome are the lowest elevations (< 491 m), gypsum soils, and creosotebush and saltbush communities.
Selective Control of Medusahead (Taeniatherum caput-medusae) in California Sagebrush Scrub using Low Rates of Glyphosate
Authors: Kyser Guy B. , Creech J. Earl , Zhang Jimin , DiTomaso Joseph M. 
Published: March 2012

AbstractAlthough glyphosate is typically used as a nonselective herbicide, low rates have the potential to provide selective control of seedling annuals in the understory of established perennial plants. In a repeated experiment on two adjacent sites at a single location near Alturas, CA (2009 and 2010), we evaluated the efficacy of glyphosate at several different rates on medusahead and nontarget species in northern California sagebrush scrub. We applied glyphosate at 10 rates ranging from 0 to 709 g ae ha−1 (0 to 18 oz product acre−1) at three separate timings in each trial: mid-March (medusahead in early seedling stage), late April to early May (tillering), and late May to early June (boot to early head). Plots measured 3 m by 9 m (10 ft by 30 ft) and were arranged in randomized complete blocks with four replications for each rate and timing. We visually estimated vegetative cover for all dominant species in July before medusahead seed drop using three 1-m2 quadrats per plot. Medusahead cover declined with increasing rates of glyphosate, and the middle application timing (at tillering) was the most effective. In rate series regression models, we achieved 95% control of medusahead with 160 g ae ha−1 glyphosate in midseason 2009, compared with 463 g ae ha−1 in early season and 203 g ae ha−1 in late season. In 2010, we achieved 95% control with 348 g ae ha−1 in midseason, compared with > 709 g ae ha−1 in early season. Medusahead seed production reflected changes in cover, though individual plants tended to produce more seed at low densities. We attribute reduced control early in the season and poorer overall control in 2010 to greater tolerance of medusahead to glyphosate at lower temperatures. Treatment effects on big sagebrush, as indicated by shoot tip vigor, were minor, although the midseason timing caused a slight reduction in vigor. These results show that low rates of glyphosate (158 to 315 g ae ha−1) at a treatment timing corresponding to medusahead tillering can give economical and effective control of medusahead without long-term damage to big sagebrush.