bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of a fatty meal on inflammatory markers in healthy volunteers with a family history of type 2 diabetes
Authors: Madec Stephanie , Corretti Valentina , Santini Eleonora , Ferrannini Ele , Solini Anna 
Published: March 2011

A family history of type 2 diabetes (T2D) confers a high risk of developing the disease, independent of that due to other common risk factors. Postprandial state is a pro-inflammatory condition associated with a transiently impaired endothelial function; an increased oxidative stress is considered as a mediator of such effects in T2D. We evaluated the short-term effect of a lipid meal on markers of early vascular damage in subjects at risk of developing T2D. A total of thirty-two healthy volunteers, divided according to the presence (FHD+) or absence (FHD − ) of a family history of T2D, underwent a fatty meal test. We measured the monocyte mRNA expressions of IL-6, IL-8 and IL-1β, and IL-6, soluble CD40 ligand (sCD40L), vascular cellular adhesion molecule-1 (VCAM-1), intracellular adhesion molecule-1 (ICAM-1) and nitrotyrosine plasma concentrations at baseline and in the post-meal phase, relating them to the lipid profile and other biochemical parameters. The basal expression of the cytokines did not differ in FHD − and FHD+ subjects; neither was it modified by the meal ingestion. IL-6 and sCD40L plasma levels, similar in the two groups in the fasting state, did not vary after the meal. VCAM-1 and ICAM-1 increased in FHD+ subjects but not in FHD − subjects. Nitrotyrosine, similar between the FHD − and FHD+ subjects at baseline, increased more in FHD+ subjects than in FHD − subjects after the meal. In conclusion, the presence of a familial history of T2D confers an abnormal endothelial activation after an oral lipid meal, coupled with an increased oxidative stress, supporting the hypothesis of an early endothelial dysfunction already present in healthy individuals prone to develop T2D.
Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients
Authors: Brasnyó Pál , Molnár Gergő A. , Mohás Márton , Markó Lajos , Laczy Boglárka , Cseh Judit , Mikolás Esztella , Szijártó István András , Mérei Ákos , Halmai Richárd , Mészáros László G. , Sümegi Balázs , Wittmann István 
Published: March 2011

Although resveratrol has widely been studied for its potential health benefits, little is known about its metabolic effects in humans. Our aims were to determine whether the polyphenol resveratrol improves insulin sensitivity in type 2 diabetic patients and to gain some insight into the mechanism of its action. After an initial general examination (including blood chemistry), nineteen patients enrolled in the 4-week-long double-blind study were randomly assigned into two groups: a resveratrol group receiving oral 2 × 5 mg resveratrol and a control group receiving placebo. Before and after the second and fourth weeks of the trial, insulin resistance/sensitivity, creatinine-normalised ortho-tyrosine level in urine samples (as a measure of oxidative stress), incretin levels and phosphorylated protein kinase B (pAkt):protein kinase B (Akt) ratio in platelets were assessed and statistically analysed. After the fourth week, resveratrol significantly decreased insulin resistance (homeostasis model of assessment for insulin resistance) and urinary ortho-tyrosine excretion, while it increased the pAkt:Akt ratio in platelets. On the other hand, it had no effect on parameters that relate to β-cell function (i.e. homeostasis model of assessment of β-cell function). The present study shows for the first time that resveratrol improves insulin sensitivity in humans, which might be due to a resveratrol-induced decrease in oxidative stress that leads to a more efficient insulin signalling via the Akt pathway.
ON A CHARACTERISTIC PROPERTY OF FINITE-DIMENSIONAL BANACH SPACES
Authors: SLAVÍK ANTONÍN 
Published: March 2011

AbstractThis paper is inspired by a counter example of J. Kurzweil published in [5], whose intention was to demonstrate that a certain property of linear operators on finite-dimensional spaces need not be preserved in infinite dimension. We obtain a stronger result, which says that no infinite-dimensional Banach space can have the given property. Along the way, we will also derive an interesting proposition related to Dvoretzky's theorem.
AN EXTENDED LOOMIS–WHITNEY INEQUALITY FOR POSITIVE DOUBLE JOHN BASES
Authors: LI AI-JUN , WANG GUANGTING , LENG GANGSONG 
Published: March 2011

AbstractIn this paper, we establish an extended Loomis–Whitney inequality for positive double John bases, which generalises Ball's result [1]. Moreover, a different extension of the Loomis–Whitney inequality is deduced.
Poor post-operative growth in infants with two-ventricle physiology
Authors: Anderson Jeffrey B. , Marino Bradley S. , Irving Sharon Y. , García-España J. Felipe , Ravishankar Chitra , Stallings Virginia A. , Medoff-Cooper Barbara 
Published: March 2011

AbstractBackgroundAdequate nutritional support is essential for normal infant growth and development. Infants with congenital cardiac disease are known to be at risk for growth failure. We sought to describe perioperative growth in infants undergoing surgical repair of two-ventricle congenital cardiac disease and assess for predictors of their pattern of growth.Materials and methodsFull-term infants who underwent surgical repair of two-ventricle congenital cardiac disease at a single institution were enrolled in a retrospective cohort study performed following a larger prospective study. Infants with facial, gastrointestinal, or neurologic anomalies, trisomy chromosomal abnormality, birth weight less than 2500 grams, or those transferred to another institution before discharge home were excluded. The primary outcome was change in weight-for-age z score from surgery to discharge. Our secondary outcome variable was post-operative hospital length of stay.ResultsA total of 76 infants met the inclusion criteria. Medain age at surgery was 5 days with a range from 1 to 44. The median weight-for-age z score at surgery was −0.2 with a range from −2.9 to 2.8 and by discharge had dropped to −1.2 with a range from −3.4 to 1.8. The median change in weight-for-age z score from surgery to discharge was −1.0 with a range from −2.3 to 0.2. Delayed post-operative nutrition (p < 0.001) and reintubation following initial post-operative extubation (p = 0.001) were associated with decrease in weight-for-age z score.ConclusionsInfants undergoing repair of two-ventricle congenital cardiac disease had poor growth in the post-operative period. This may be mitigated by early initiation of post-operative nutrition.
Reduced Cognitive Control of a Visually Bistable Image in Schizophrenia
Authors: McBain Ryan , Norton Daniel J. , Kim Jejoong , Chen Yue 
Published: March 2011

AbstractSchizophrenia is associated with the inability to control and coordinate thoughts, actions, and perceptions. In conventional assessments of cognitive control, multiple sensory features of stimuli are concomitantly manipulated, introducing a confounding role of bottom-up perceptual information. To overcome this difficulty, we used an ambiguous visual stimulus (Necker cube), which allowed measurement of cognitive control with constant sensory input. Subjects (20 patients, 20 controls) were asked to control their perception of a transparent Necker cube by keeping a designated plane at the front or back of the stimulus, the position of which is perceptually bistable. Patients were highly deficient at controlling their perception of the cube. When a visual feature (the luminance contrast between a designated cube plane and the other planes) was systematically manipulated, an interaction was found whereby schizophrenia patients no longer under-performed on the highest contrast condition. These results show patients’ impairment of controlling perception in the absence of visual modulation and suggest the potential utility of perceptually based approaches to cognitive remediation in schizophrenia. (JINS, 2011, 551–556)
Live, Video-Rate Super-Resolution Microscopy Using Structured Illumination and Rapid GPU-Based Parallel Processing
Authors: Lefman Jonathan , Scott Keana , Stranick Stephan 
Published: March 2011

AbstractStructured illumination fluorescence microscopy is a powerful super-resolution method that is capable of achieving a resolution below 100 nm. Each super-resolution image is computationally constructed from a set of differentially illuminated images. However, real-time application of structured illumination microscopy (SIM) has generally been limited due to the computational overhead needed to generate super-resolution images. Here, we have developed a real-time SIM system that incorporates graphic processing unit (GPU) based in-line parallel processing of raw/differentially illuminated images. By using GPU processing, the system has achieved a 90-fold increase in processing speed compared to performing equivalent operations on a multiprocessor computer—the total throughput of the system is limited by data acquisition speed, but not by image processing. Overall, more than 350 raw images (16-bit depth, 512 × 512 pixels) can be processed per second, resulting in a maximum frame rate of 39 super-resolution images per second. This ultrafast processing capability is used to provide immediate feedback of super-resolution images for real-time display. These developments are increasing the potential for sophisticated super-resolution imaging applications.
Contributions of Morphological Awareness Skills to Word-Level Reading and Spelling in First-Grade Children With and Without Speech Sound Disorder
Authors: Apel Kenn , Lawrence Jessika 
Published: March 2011

Purpose
In this study, the authors compared the morphological awareness abilities of children with speech sound disorder (SSD) and children with typical speech skills and examined how morphological awareness ability predicted word-level reading and spelling performance above other known contributors to literacy development.

Method
Eighty-eight first-grade students—44 students with SSD and no known history of language deficiencies, and 44 students with typical speech and language skills—completed an assessment battery designed to measure speech sound production, morphological awareness, phonemic awareness, letter-name knowledge, receptive vocabulary, word-level reading, and spelling abilities.

Results
The children with SSD scored significantly lower than did their counterparts on the morphological awareness measures as well as on phonemic awareness, word-level reading, and spelling tasks. Regression analyses suggested that morphological awareness predicted significant unique variance on the spelling measure for both groups and on the word-level reading measure for the children with typical skills.

Conclusion
These results suggest that children with SSD may present with a general linguistic awareness insufficiency, which puts them at risk for difficulties with literacy and literacy-related tasks.
Changes in zooplankton biomass in the Bay of Quinte with the arrival of the mussels, Dreissena polymorpha and D. rostiformis bugensis, and the predatory cladoceran, Cercopagis pengoi: 1975 to 2008
Authors: Bowen Kelly L. , Johannsson Ora E. 
Published: March 2011

Long term monitoring of Lake Ontario's Bay of Quinte provides the opportunity to examine the impact of dreissenid invasion on the zooplankton community. Weekly or biweekly zooplankton samples have been collected from 1975 to 2008 at 3 stations: Belleville (B), Hay Bay (HB), and Conway (C) along a trophic and depth gradient down the bay. Rotifers have been collected since 2000. Biomass estimates based on measured zooplankton lengths started in 1995. Archived seasonal composite samples prior to 1995 were reanalysed and biomass recalculated from length-weight equations to allow for comparable data in trend analysis. Mean May 1– October 6 zooplankton biomass was low from 1975 into the early 1980s and peaked between 1982–1983 and 1991. Biomass fell during the cold summer of 1992 associated with the Pinatubo eruption and was low after the invasion of dreissenid mussels. From 1979–1991 (after phosphorus control and prior to dreissenid invasion), biomass averaged 265, 253 and 84 mg m−3 at B, HB and C, respectively. Seasonal biomass of most zooplankton groups, as well as total biomass, was significantly lower at all stations after the dreissenid invasion. Cladocerans still dominated zooplankton biomass after the invasion, averaging 56% to 80% of the total. Cyclopoid numbers and biomass fell dramatically.
After the invasion of Cercopagis pengoi in 1999, calanoid and cyclopoid biomass at HB and C decreased by approximately 50%. Bosmina biomass did not change. Seasonal mean rotifer biomass over the 2000 to 2008 period was 1.9% to 4.4% of total zooplankton biomass.
Reductions in zooplankton following dreissenid and C. pengoi invasions are thought to be caused by both direct predation of microzooplankton (e.g. nauplii) by mussels and copepods by C. pengoi (at C and HB), and competition between zooplankton and dreissenids for food resources.
Nanosized perovskite oxide NdFeO
3 as material for a carbon-monoxide catalytic gas sensor
Authors: Ho Truong Giang , Ha Thai Duy , Pham Quang Ngan , Giang Hong Thai , Thu Do Thi Anh , Nguyen Ngoc Toan 
Published: March 2011

Abstract
In this paper, research on a CO catalytic gas sensor based on nano-crystalline perovskite oxide NdFeO
3 designed for exhaust gas measurement is presented. Nano-crystalline oxide NdFeO
3 was synthesized by a sol–gel citrate technique. The gas sensing characteristics of this sensor were investigated in the concentration range of CO between 0 and 5 vol.% in air. The influences of C
3
H
8, C
4
H
16 gases, relative humidity and air-flow rate on the cross-sensitivity of the CO sensor were also studied.
A micro-extractor for concentration and determination of lead in water
Authors: Van Man Tran , Berthier Jean , Ozil Patrick , Sarrut Nicolas 
Published: March 2011

Abstract
In this work, we present the design, fabrication and characterization of a novel micro-extractor that performs on-line extraction–concentration–detection (ECD) of target molecules flowing in a carrier liquid. The system comprises a primary microchannel containing a flowing aqueous carrier liquid and a secondary organic storage fluid circulating in an adjacent channel. The interfaces between the two immiscible fluids are stabilized by vertical micro-pillars. The system encompasses three functions: (i) extraction of the target molecules from the carrier fluid through the pillar-stabilized interfaces, (ii) concentration of the targets in the secondary organic solvent due to its very low—or zero—velocity and (iii) on-line detection via optical spectrometry. We successively present the analysis of the physics of the system, which has led us to a specific design, then the microfabrication of the chip, and finally we demonstrate the extraction, concentration and detection of lead ions (Pb
2+) from a water flow.
Baking a mass-spectrometry data PIE with McMC and simulated annealing: predicting protein post-translational modifications from integrated top-down and bottom-up data
Authors: Jefferys Stuart R. , Giddings Morgan C. 
Published: March 2011

Abstract
Motivation: Post-translational modifications are vital to the function of proteins, but are hard to study, especially since several modified isoforms of a protein may be present simultaneously. Mass spectrometers are a great tool for investigating modified proteins, but the data they provide is often incomplete, ambiguous and difficult to interpret. Combining data from multiple experimental techniques—especially bottom-up and top-down mass spectrometry—provides complementary information. When integrated with background knowledge this allows a human expert to interpret what modifications are present and where on a protein they are located. However, the process is arduous and for high-throughput applications needs to be automated.
Results: This article explores a data integration methodology based on Markov chain Monte Carlo and simulated annealing. Our software, the Protein Inference Engine (the PIE) applies these algorithms using a modular approach, allowing multiple types of data to be considered simultaneously and for new data types to be added as needed. Even for complicated data representing multiple modifications and several isoforms, the PIE generates accurate modification predictions, including location. When applied to experimental data collected on the L7/L12 ribosomal protein the PIE was able to make predictions consistent with manual interpretation for several different L7/L12 isoforms using a combination of bottom-up data with experimentally identified intact masses.
Availability: Software, demo projects and source can be downloaded from http://pie.giddingslab.org/
Contact: morgan@giddingslab.org.
Supplementary information: Supplementary data are available at Bioinformatics online
Reactive Oxygen Species and Nitric Oxide Mediate Actin Reorganization and Programmed Cell Death in the Self-Incompatibility Response of Papaver
Authors: Wilkins Katie A. , Bancroft James , Bosch Maurice , Ings Jennifer , Smirnoff Nicholas , Franklin-Tong Vernonica E. 
Published: March 2011

Abstract
Pollen-pistil interactions are critical early events regulating pollination and fertilization. Self-incompatibility (SI) is an important mechanism to prevent self-fertilization and inbreeding in higher plants. Although data implicate the involvement of reactive oxygen species (ROS) and nitric oxide (NO) in pollen-pistil interactions and the regulation of pollen tube growth, there has been a lack of studies investigating ROS and NO signaling in pollen tubes in response to defined, physiologically relevant stimuli. We have used live-cell imaging to visualize ROS and NO in growing Papaver rhoeas pollen tubes using chloromethyl-2′7′-dichlorodihydrofluorescein diacetate acetyl ester and 4-amino-5-methylamino-2′,7′-difluorofluorescein diacetate and demonstrate that SI induces relatively rapid and transient increases in ROS and NO, with each showing a distinctive “signature” within incompatible pollen tubes. Investigating how these signals integrate with the SI responses, we show that Ca2+ increases are upstream of ROS and NO. As ROS/NO scavengers alleviated both the formation of SI-induced actin punctate foci and also the activation of a DEVDase/caspase-3-like activity, this demonstrates that ROS and NO act upstream of these key SI markers and suggests that they signal to these SI events. These data represent, to our knowledge, the first steps in understanding ROS/NO signaling triggered by this receptor-ligand interaction in pollen tubes.
Solid-state transformations in the β-form of chlorpropamide on cooling to 100 K
Authors: Drebushchak Tatiana N. , Drebushchak Valeri A. , Boldyreva Elena V. 
Published: March 2011

A single-crystal X-ray diffraction study of the effect of cooling down to 100 K on the β-form of chlorpropamide, 4-chloro-N-(propylaminocarbonyl)benzenesulfonamide, has revealed reversible phase transitions at ∼ 257 K and between 150 and 125 K: β (Pbcn, Z′ = 1)  βII (P2/c, Z′ = 2)  βIII (P2/n, a′ = 2a, Z′ = 4); the sequence corresponds to cooling. Despite changes in the space group and number of symmetry-independent molecules, the volume per molecule changes continuously in the temperature range 100–300 K. The phase transition at ∼ 257 K is accompanied by non-merohedral twinning, which is preserved on further cooling and through the second phase transition, but the original single crystal does not crack. DSC (differential scanning calorimetry) and X-ray powder diffraction investigations confirm the phase transitions. Twinning disappears on heating as the reverse transformations take place. The second phase transition is related to a change in conformation of the alkyl tail from trans to gauche in 1/4 of the molecules, regularly distributed in the space. Possible reasons for the increase in Z′ upon cooling are discussed in comparison to other reported examples of processes (crystallization, phase transitions) in which organic crystals with Z′ > 1 have been formed. Implications for pharmaceutical applications are discussed.
Combined ifosfamide, etoposide and oxalipatin chemotherapy, a low‐toxicity regimen for first‐relapsed or refractory Hodgkin lymphoma after ABVD/EBVP: a prospective monocentre study on 34 patients
Authors: Sibon David , Ertault Marjane , Al Nawakil Chadi , de Bazelaire Cédric , Franchi Patricia , Brière Josette , de Kerviler Eric , Beranger Nathalie , Thieblemont Catherine , Brice Pauline 
Published: March 2011

SummaryAround 20% of Hodgkin lymphoma (HL) patients are refractory to first‐line therapy with ABVD (adriamycin–bleomycin–vinblastine–dacarbazine) or relapse after complete remission. Salvage regimens frequently have delayed courses or require dose‐reduction because of haemotoxicity. We evaluated the IVOx (ifosfamide–etoposide–oxaliplatin) salvage regimen in terms of response rate, toxicity and stem‐cell mobilization. Thirty‐four patients with relapsed/refractory HL after anthracycline‐containing chemotherapy prospectively received IVOx, consisting of ifosfamide (1500 mg/m2 days 1–3), etoposide (150 mg/m2 days 1–3) and oxaliplatin (130 mg/m2 day 1). Patients <65 years old received high‐dose therapy followed by autologous stem‐cell transplantation (HDT–ASCT). Response was assessed by computed and positron‐emission tomographies. Overall and complete response rates were 76% and 32%, respectively, after 2 cycles. Three episodes of febrile neutropenia occurred, and three patients required dose‐reductions. Twenty‐six patients underwent HDT–ASCT. With median follow‐up at 5 years, the 5‐year overall and event‐free survival rates were 74% and 63%, respectively. IVOx is a well‐tolerated outpatient regimen for relapsed HL, that does not hamper stem‐cell mobilization, achieves good response rates and compares favourably with previously published salvage regimens.
Decreased expression of interleukin‐27 in immune thrombocytopenia
Authors: Liu Xin‐guang , Ren Juan , Yu Yuan , Sun Lin , Shi Yan , Qin Ping , Yang Lei , Ma Shi‐hui , Dong Xiao‐yuan , Ma Dao‐xin , Qu Xun , Guo Cheng‐shan , Chen Chun‐yan , Hou Ming , Peng Jun 
Published: March 2011

SummaryPrimary immune thrombocytopenia (ITP) is an immune‐mediated disorder in which disturbed cytokine profiles have been found. Interleukin‐27 (IL27) has been shown to bear both proinflammatory and anti‐inflammtory effects. In the present study, plasma levels of IL27, interferon gamma (IFNG), IL4, and IL17A were determined by enzyme‐linked immunosorbent assay in 23 active ITP patients, 20 patients in remission and 20 healthy controls. mRNA expression levels of IL27, EBI3, IL27 receptor (IL27RA), IL17A and RAR‐related orphan receptor C (RORC) were determined by real‐time quantitative polymerase chain reaction. Significantly lower levels of plasma IL27, IL4, mRNA expression of IL27, EBI3 and higher levels of plasma IFNG as well as mRNA expression of IL17A, RORC were observed in active ITP patients compared with healthy controls or patients in remission. No statistical difference was found in IL27RA mRNA expression or plasma IL17A levels among active ITP patients and controls. A negative correlation was found between the IL27 and RORC mRNA expression levels in active ITP patients. Our data demonstrated that active ITP patients had decreased plasma and mRNA expression levels of IL27, suggesting that it might be involved in the pathophysiological process of ITP.