P4-12-03: Post-Diagnosis Weight Gain in Breast Cancer Survivors: When Should We Intervene?
Authors: Bradshaw PT , Cleveland RJ , Stevens J , Rosamond W , Abrahamson PE , Teitelbaum SL , Neugut AI , Gammon MD 
Published: June 2012

Abstract
Significance. Weight gain after breast cancer diagnosis is common and has been linked to poor prognosis. Studies of the etiology and longitudinal pattern of post-diagnosis weight gain are limited, yet are critical to developing effective prevention strategies to enhance ***survival.. Approach. We investigated the longitudinal pattern and determinants of post-diagnosis weight gain among 1,436 breast cancer survivors. The population-based cohort included women newly diagnosed with a first primary in situ or invasive breast cancer. Subjects were interviewed within 6 months of diagnosis and again 5 years later to ascertain factors related to survival, including self-reported anthropometric measures. We employed: adjusted random effects linear regression to identify factors related to weight change during the follow-up; multiple imputation to account for missing data; and Wald tests to test for significance of interactions with follow-up time.
Results. Average weight gain was 0.74 kilograms (kg) during the first year after diagnosis and 2.39 kg at the follow-up interview. The strongest predictors of post-diagnosis gain were body size characteristics before diagnosis, which varied with time since diagnosis. Compared to women with body mass index (BMI, kg/m2) 18.5−24.9 1 year before diagnosis, those with greater BMI were more likely to gain weight during the first year after diagnosis [difference in mean yearly increase: BMI 25.0−29.9 vs. 18.5−24.9 (95% confidence interval): 1.93 kg/year (0.50, 3.37); BMI &gt;=30.0 vs. 18.5−24.9: 0.47 kg/year (0.24, 0.71)] and after the first year [5.17 kg/year (3.68, 6.66) and 0.93 kg/year (0.58, 1.28), respectively], with the effect greater during the first year (p-interaction: &lt;0.001). A pre-diagnosis weight gain of more than 10% since age 20 was also associated with post-diagnosis weight gain [during year 1, difference in mean yearly increase compared to maintenance within 3% age 20 weight: 2.32 kg/year (0.59, 4.05); after year 1: 0.53 kg/year (0.17, 0.89)] with the effect again stronger during the first year (p-interaction: 0.02). Modest associations, which varied only slightly with time, included: increases in post-diagnosis weight gain with chemotherapy, tumor characteristics indicative of poor prognosis, and a previous diagnosis of hypertension, blood clots, or diabetes; and decreases with increasing recreational physical activity and a history of myocardial infarction.
Conclusions. Greater pre-diagnosis BMI and pre-diagnosis adult weight gain are strongly related to post-diagnosis weight gain among breast cancer survivors. The rate of post-diagnosis weight gain appears to be faster during the first year than after, suggesting that interventions to prevent post-diagnosis weight gain may be most important during the first year after diagnosis, especially among women who with BMI &gt;= 25.0 1 year prior to diagnosis.
Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P4-12-03.