bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing the effects of Bone+B® xenograft and InterOss® xenograft bone material on rabbit calvaria bone defect regeneration
Authors: Naini Afshin Yadegari , Kobravi Sepehr , Jafari Aida , Lotfalizadeh Mohammadhassan , Lotfalizadeh Narges , Farhadi Sareh 
Published: May 2024

AbstractBackgroundThe bone regeneration therapy is often used in patients with inadequate bone support for implants, particularly following tooth extractions. Xenografts derived from animal tissues are effective bone reconstructive options that resist resorption and pose a low risk of transmitting disease. Therefore, these implants may be a good option for enhancing and stabilizing maxillary sinuses. The purpose of this study was to compare two xenografts, Bone+B® and InterOss®, for the reconstruction of rabbit calvaria defects.Methods and MaterialsThe study involved seven male New Zealand white rabbits. In the surgical procedure, 21 spots were created on both sides of the midline calvarium by creating three 8‐millimeter defects. A control group was used, as well as two treatment groups utilizing Bone+B® Grafts and InterOss® Grafts. After 3 months, the rabbits were euthanized, followed by pathological evaluation. Analysis of these samples focused on bone formation, xenograft remaining material, and inflammation levels, using Adobe Photoshop CS 8.0 and SPSS version 24.ResultsWith the application of Bone+B® graft, bone formation ranged from 32% to 45%, with a mean of 37.80% (±5.63), and the remaining material ranged from 28% to 37%, with a mean of 32.60% (±3.65). Using InterOss® grafts, bone formation was 61% to 75%, the mean was 65.83% (±4.75), and the remaining material was 9% to 18%, with a mean of 13.17% (±3.06). The bone formation in the control group ranged from 10% to 25%, with a mean of 17.17% (±6.11). InterOss® had lower inflammation levels than other groups, but the difference was not statistically significant (p > .05).ConclusionInterOss® bone powder is the best option for maxillofacial surgery and bone reconstruction. This is due to more bone formation, less remaining material, and a lower inflammation level. Compared to the control group, Bone+B® improves healing and bone quality, thus making it an alternative to InterOss®.
Optimizing esthetic zone periodontal regeneration in a 1–2‐wall infrabony defect using recombinant human platelet‐derived growth factor BB and β‐tricalcium phosphate: A case report
Authors: Rattanaprukskul Kantapon , Neiva Rodrigo , Korostoff Jonathan 
Published: May 2024

AbstractObjectivePeriodontitis is an inflammatory condition induced by subgingival bacterial dysbiosis, resulting in inflammatory‐mediated destruction of tooth‐supporting structures, potentially leading to the formation of infrabony defects. This case report describes the treatment of a patient who presented with a combination 1–2‐wall defect on tooth 21. To maintain the residual periodontal attachment and minimize esthetic consequences, a regenerative approach was performed using recombinant human platelet‐derived growth factor‐BB (rh‐PDGF‐BB) and β‐tricalcium phosphate (β‐TCP).Materials and MethodsAt the time of postscaling/root planing reevaluation, a 34‐year‐old Asian male initially diagnosed with molar/incisor pattern stage III grade C periodontitis exhibited a 6‐mm residual probing depth on the mesiopalatal aspect of tooth 21. Periodontal regenerative surgery was performed using rh‐PDGF‐BB with β‐TCP, without the use of a membrane.ResultsAt the 1‐year follow‐up, a significant reduction in probing depth and radiographic evidence of bone fill were observed. Additionally, re‐entry surgery for implant placement at site tooth 23 confirmed bone fill in the defect on tooth 21.ConclusionThese results demonstrate the efficacy of rh‐PDGF‐BB with β‐TCP in enhancing periodontal regeneration and support its use as a treatment option when treating poorly contained infrabony defects in the esthetic zone.
Convergent Paired Electrolysis for [3+2] Cycloaddition of Azidotrimethylsilane with N‐Heterocycles
Authors: Bankura Abhijit , Ghosh Subhadeep , Biswas Sumit , Das Indrajit 
Published: May 2024

AbstractA widely used method to obtain tetrazoles is through the azide and nitrile [3+2] cycloaddition. However, this process often involves using non‐recyclable transition metals or Lewis acid catalysts and stoichiometric amounts of oxidants and additives, which reduces atom efficiency. We have discovered a convergent paired electrochemical reaction to perform this cycloaddition reaction, without the need for metal catalysts or oxidants. This tetrazolation strategy uses azidotrimethylsilane (TMSN3) and N‐heterocycles in an undivided cell at a constant current. We use a mixture of CH3CN and equivalent amounts of H2O as co‐solvent at room temperature. It is crucial to produce a stoichiometric amount of active hydroxyl ions through the cathodic reduction of water. Cyclic voltammetry (CV) studies and control experiments confirm that the cycloaddition reaction is specific to the electrode electron transfer process, eliminating the need for a mediator to shuttle electrons. This metal‐ and oxidant‐free strategy is highly compatible with different functional groups and produces products with moderate to good yields. We have successfully tetrazolated bioactive compounds at a late stage, scaled up batches efficiently, and synthesized free amino‐containing N‐heterocycles via denitrogenation of tetrazoles.
An intelligent optimized users resource searching and nearest peer identification in Mobile networks
Authors: Karunkuzhali Danassou , Raja Murali Prasad , Venkatesan Kondan Janardhanan Prasanna 
Published: May 2024

SummaryMobile networks have advanced in many fields to share information with others. But finding the required resources for each user to share the data is a complex task because of the moving environment. So, the present research article has introduced a novel Chimp‐based Random Forest Peer Identification Framework (CbRFPIF) in the mobile environment. Initially, the required nodes were designed dynamically in the moving background. Hence, the designed wireless moving environment has included sender, peer, and receiver nodes. Moreover, the Chimp fitness model predicted the users' requested resources in the primary stage, then the nearest peer and the user locations were predicted. Consequently, the requested resource by users was distributed to the particular closest peers, and the peer forwarded the data to the specific users. Finally, the planned model is simulated in the NS2 environment, and the communication parameters were calculated and compared with other associated models, which gained the highest throughput and search rate.
Male–female differences following concomitant coronary artery bypass grafting and aortic valve replacement surgery
Authors: Krey Rebecca , Jakob Moritz , Karck Matthias , Arif Rawa , Farag Mina 
Published: May 2024

AbstractAimsCombined coronary artery bypass grafting (CABG) and aortic valve replacement (AVR), and female sex are associated with increased perioperative mortality in clinical risk scores. This study investigated male–female differences in short‐term outcome stratified by age groups.Methods and resultsAll patients undergoing AVR and CABG between January 2001 and June 2021 at our institution were included. 1963 patients were grouped by decades into: 59 years and younger (n = 127), 60–69 (n = 471), 70–79 (n = 1070), and 80 years and older (n = 295). The primary end points of this study were 30 and 180 days mortality. Secondary end points were influence of preoperative risk factors and impact of sex on survival and postoperative major adverse events. Female patients showed higher 30 and 180 days mortality after combined CABG and AVR surgery (8.3% vs. 4.2%, P < 0.01; 15.8% vs. 9.4%, P < 0.01). Stratified by age groups, 30 and 180 days mortality remained significantly higher in septuagenarians (9.6% vs. 2.5%, P < 0.01; 16.3% vs. 7.7%, P < 0.01). Females were significantly older, had better preserved left ventricular function, and higher incidence of diabetes mellitus compared with male patients in this subgroup (P < 0.01; P = 0.01; P < 0.01). Additionally, females received significantly less internal mammary artery (IMA) conduits (P < 0.01). Female sex (OR: 3.33, 95% CI: [1.76–6.31]; 1.93, [1.22–3.06]), higher age (1.28, [1.13–1.45]; 1.16, [1.06–1.26]), diabetes mellitus (1.93, [1.03–3.60]; 1.70, [1.08–2.67]) and LVEF <30% (3.26, [1.48–7.17]; 2.23, [1.24–4.02]) were correlated with 30 and 180 days mortality, respectively. Upon multivariable testing, sex (1.77, [1.21–2.58]) and LVEF <30% (3.71, [2.39–5.76]) remained independent predictors for major adverse postoperative events. Infrequent use of IMA grafts was associated with increased 30 and 180 days mortality as well as adverse events (0.47, [0.25–0.87]; 0.46, [0.29–0.72]; 0.61, [0.42–0.88]).ConclusionsSex disparities in baseline characteristics may delay operative intervention in female patients. The inherent risk profiles might be responsible for outcome differences in septuagenarians.
Sacubitril/valsartan for the treatment of non‐obstructive hypertrophic cardiomyopathy: An open label randomized controlled trial (SILICOFCM)
Authors: Velicki Lazar , Popovic Dejana , Okwose Nduka C. , Preveden Andrej , Tesic Milorad , Tafelmeier Maria , Charman Sarah J. , Barlocco Fausto , MacGowan Guy A. , Seferovic Petar M. , Filipovic Nenad , Ristic Arsen , Olivotto Iacopo , Maier Lars S. , Jakovljevic Djordje G. ,   SILICOFCM Investigators
Published: May 2024

AimSacubitril/valsartan treatment reduces mortality and hospitalizations in heart failure with reduced ejection fraction but has limited application in hypertrophic cardiomyopathy (HCM). The aim of this study was to evaluate the effect of sacubitril/valsartan on peak oxygen consumption (VO2) in patients with non‐obstructive HCM.Methods and resultsThis is a phase II, randomized, open‐label multicentre study that enrolled adult patients with symptomatic non‐obstructive HCM (New York Heart Association class I–III) who were randomly assigned (2:1) to receive sacubitril/valsartan (target dose 97/103 mg) or control for 16 weeks. The primary endpoint was a change in peak VO2. Secondary endpoints included echocardiographic measures of cardiac structure and function, natriuretic peptides and other cardiac biomarkers, and Minnesota Living with Heart Failure quality of life. Between May 2018 and October 2021, 354 patients were screened for eligibility, 115 patients (mean age 58 years, 37% female) met the study inclusion criteria and were randomly assigned to sacubitril/valsartan (n = 79) or control (n = 36). At 16 weeks, there was no significant change in peak VO2 from baseline in the sacubitril/valsartan (15.3 [4.3] vs. 15.9 [4.3] ml/kg/min, p = 0.13) or control group (p = 0.47). No clinically significant changes were found in blood pressure, cardiac structure and function, plasma biomarkers, or quality of life.ConclusionIn patients with HCM, a 16‐week treatment with sacubitril/valsartan was well tolerated but had no effect on exercise capacity, cardiac structure, or function.
Research on optimization of conductivity of multilevel fractures in tight sandstone based on similar circuit principle
Authors: Xiao Hui , Zhang Lei , Xiang Jiuzhou , Lu Yu 
Published: May 2024

AbstractVolume fracturing technology is commonly used to develop tight sandstone reservoirs. During the fracturing process, it is important to not only focus on achieving a larger stimulation volume but also on creating a fracture network conductivity that is suitable for the tight reservoir. However, while there have been numerous studies on optimizing the conductivity of individual fractures, the optimization of fracture network conductivity is still incomplete. To address this issue, a reservoir numerical model is established to optimize the equivalent conductivity of the post‐fracturing fracture network, considering it as a high permeability zone, optimizing the equivalent conductivity to 9.7 μm2 cm. Utilizing the discrete element theory, a “pipe domain” discrete element model is developed to analyze fracture expansion. The findings indicate that the ratios of first‐level, second‐level, and third‐level fractures differ based on the number of clusters, such as 1:4:8 and 1:5:9 for three‐cluster and four‐cluster perforations. By applying the hydropower similarity principle, the fracture network is treated as a three‐level circuit to determine the conductivity of each fracture level. Finally, the model is fitted based on conductivity to determine the optimal fracture conductivity for different fracture number ratios, thereby enhancing the flow capability.
Varied root effects on soil detachment with growth time and hydrodynamic characteristics
Authors: Liu Junyang , Zhou Zhengchao , Chen Hao , Han Weixiao 
Published: May 2024

AbstractPlant roots significantly reduce soil detachment by overland flow. However, there have been few studies on how plant growth time and hydrodynamic characteristics affect the erosion‐reducing potential of plant roots. This study cultivated ryegrass (Lolium perenne L.) and alfalfa (Medicago sativa L.) as representative of plants possessing fibrous roots and taproots, respectively, in silty soil from the Loess Plateau, China. Root‐soil composites were collected monthly from March to September 2021 and subjected to flow scouring in a hydraulic flume at a 15° slope using five different flow discharges (0.05, 0.1, 0.15, 0.2 and 0.3 L s−1). The results of the study indicated that root length density, root surface area density and root mass density exhibited a significant increase during the early growth phase, followed by a slight decrease. All parameters of fibrous roots revealed greater values than those of taproots, except for root mass density. The reduction in soil detachment under varying flow shear stresses showed a significant increase during the early phases of growth, followed by a gradual decline. Notably, fibrous roots demonstrated a greater impact on soil detachment than taproots, and this discrepancy fluctuated over time. Moreover, the contributions of fibrous and taproots to reducing soil detachment decreased from 55.81% to 39.66% and from 38.21% to 20.99% with increasing flow shear stress, respectively. It indicated that the erosion‐reducing potential of plant roots was greater when subjected to low‐flow shear stress compared to high‐flow shear stress. This study can provide a scientific basis for understanding the erosion‐reducing potential of plant roots at different growing stages and under varying hydrodynamic characteristics.
Metabolome and transcriptome analysis reveal the effect of methyl jasmonate on phytosterol biosynthesis in Brassica napus
Authors: Wang Xueyan , Liu Min , Yang Ruinan , Cui Xiaobo , Liu Jie , Zhang Yu , He Yizhou , Yu Li , Ma Fei , Zhang Xiong , Zhang Yuanyuan , Liu Shengyi , Li Peiwu , Zhang Liangxiao 
Published: May 2024

AbstractPhytosterols are a group of nonpharmacological alternatives to prevent or control dyslipidemias and cardiovascular disease. Increasing the phytosterol content in rapeseed oil is important to enhance daily phytosterol intake. However, the mechanisms of biosynthesis and regulation of phytosterol in rapeseed remain unclear. In this study, two representative rapeseed cultivars with extremely high (H286) and low (H174) phytosterol content were selected and treated with various concentrations (0.5−5.0 mM) of methyl jasmonate (MeJA). The results showed that treatment with 1 mM MeJA increased the phytosterol content of H174 and H286 by 17% and 27%, respectively. Based on the multiomics data, a gene‐phytosterol regulatory network was constructed. We deduced that MeJA down‐regulated the expression level of BnaA07.SCL15, BnaC05.MYB61, and BnaC03.AGL2, thereby promoting the phytosterol biosynthesis , and which were validated through the transient expression in tobacco. Notably, overexpression of Arabidopsis BnaA07.SCL15 exhibited a significant decrease in their phytosterol content. Additionally, an integrative analysis of the high‐resolution metabolome and transcriptome revealed that the accumulation patterns of 997 metabolites were highly correlated with their corresponding gene expression patterns. MeJA also significantly affected flavonoid biosynthesis, α‐linolenic acid metabolism, and amino acid metabolism. Furthermore, BnaA09.TT8 and BnaC09.TT8 were found to regulate of flavonoids. Overall, this study provides valuable insights into the phytosterol biosynthesis in rapeseed and offers a simple and effective approach for improving rapeseed quality.
Valorization of various nut residues grown in Turkiye: Antioxidant, anticholinesterase, antidiabetic, and cytotoxic activities1
Authors: Kutlu Gozde 
Published: May 2024

AbstractThe utilization of plant‐based residues has been extensively employed for the control of diverse illnesses, owing to their safety and minimal adverse effects. In the current study, it was aimed for the characterization of the bioactive, enzyme inhibitory, and cytotoxic activities of fresh pistachio shell skin (FPSS), green walnut husk and walnut membrane (GWH), almond outer shell and inner brown skin (ASIS), as well as peanut husk and inner skin (PHIS) to be used as industrial food processing by‐products. The results showed that the samples exhibited different extraction yields, with GWH having the highest percentage at 15.18%, followed by FPSS at 12.81%, ASIS at 10.29%, and PHIS at 7.80%. FPSS had the highest total phenolic content (16.28 mg gallic acid equivalents (GAE)/g) as well as the best antioxidant capabilities for DPPH (8.96 mg Trolox equivalent (TE)/g), FRAP (11.46 mg TE/g), and ABTS (22.38 mg TE/g) assays. FPSS was followed by PHIS, ASIS, and GWH, respectively. Moreover, the extracts exhibited relatively low activity against acetylcholinesterase, α‐glucosidase, and α‐amylase compared to standard acarbose or galantamine. Furthermore, the extracts may have the potential to induce cytotoxic effects, varying from moderate to mild, on both cancerous (IC50 = 454.55–617.28 μg/mL) and healthy cells (IC50 = 438.60–490.20 μg/mL). The results of this research showed that shell residues of nut hold promise for a variety of industrial applications spanning the food, pharmaceutical, and cosmetic sectors.
Optimization of citrus fiber‐enriched vegan cream cheese alternative and its influence on chemical, physical, and sensory properties
Authors: Gurbuz Basak , Cayir Merve , Akdeniz Esra , Akyıl Öztürk Saniye , Karaman Safa , Karimidastjerd Atefeh , Toker Omer Said , Palabıyık İbrahim , Konar Nevzat 
Published: May 2024

AbstractDairy product alternatives have increased in recent years as a result of medical prescriptions or personal preferences. The main purpose of the present study was to optimize vegan‐based cream cheese formulation added with citrus fiber considering the textural and physicochemical properties of the samples. The physicochemical (pH value, water activity, and color), texture, microstructure, and sensory properties of manufactured vegan‐based cream cheese were characterized and compared to those of a commercial one. Three optimized products were produced, according to the textural properties. The addition of citrus fiber did not affect the pH and water activity values of the cheese samples significantly. Although citrus fiber had an effect on the color values of the samples, a significant difference in the sensory scores was not recorded by the panelists. The sample having 1.21% citrus fiber (A) showed a hardness value similar to that of control sample and it received high sensory appreciation. The sample added with 1.41% citrus fiber (B) was scored high by the panelists, with no significant difference compared to commercial cream cheese, even though it showed high hardness. According to the results of the current research, vegan‐based cream cheese can be produced as a promising food as a new alternative to milk and dairy products.
Appetitive conditioning with pornographic stimuli elicits stronger activation in reward regions than monetary and gaming‐related stimuli
Authors: Krikova Kseniya , Klein Sanja , Kampa Miriam , Walter Bertram , Stark Rudolf , Klucken Tim 
Published: May 2024

AbstractAppetitive conditioning plays an important role in the development and maintenance of pornography‐use and gaming disorders. It is assumed that primary and secondary reinforcers are involved in these processes. Despite the common use of pornography and gaming in the general population appetitive conditioning processes in this context are still not well studied. This study aims to compare appetitive conditioning processes using primary (pornographic) and secondary (monetary and gaming‐related) rewards as unconditioned stimuli (UCS) in the general population. Additionally, it investigates the conditioning processes with gaming‐related stimuli as this type of UCS was not used in previous studies. Thirty‐one subjects participated in a differential conditioning procedure in which four geometric symbols were paired with either pornographic, monetary, or gaming‐related rewards or with nothing to become conditioned stimuli (CS + porn, CS + game, CS + money, and CS−) in an functional magnetic resonance imaging study. We observed elevated arousal and valence ratings as well as skin conductance responses for each CS+ condition compared to the CS−. On the neural level, we found activations during the presentation of the CS + porn in the bilateral nucleus accumbens, right medial orbitofrontal cortex, and the right ventral anterior cingulate cortex compared to the CS−, but no significant activations during CS + money and CS + game compared to the CS−. These results indicate that different processes emerge depending on whether primary and secondary rewards are presented separately or together in the same experimental paradigm. Additionally, monetary and gaming‐related stimuli seem to have a lower appetitive value than pornographic rewards.
Low methylation marker levels among human papillomavirus‐vaccinated women with cervical high‐grade squamous intraepithelial lesions
Authors: Louvanto Karolina , Verhoef Lisanne , Pimenoff Ville , Eriksson Tiina , Leppälä Siiri , Lagheden Camilla , Gray Penelope , Scibior‐Bentkowska Dorota , Sumiec Elizabeth , Nieminen Pekka , Dillner Joakim , Berkhof Johannes , Meijer Chris J. L. M. , Lehtinen Matti , Nedjai Belinda , Heideman Daniëlle A. M. 
Published: May 2024

AbstractCervical cancer screening programs, including triage tests, need redesigning as human papillomavirus (HPV)‐vaccinated women are entering the programs. Methylation markers offer a potential solution to reduce false‐positive rates by identifying clinically relevant cervical lesions with progressive potential. In a nested case–control study, 9242 women who received the three‐dose HPV16/18‐vaccine at ages 12–15 or 18 in a community‐randomized trial were included. Subsequently, they were re‐randomized for either frequent or infrequent cervical cancer screening trials. Over a 15‐year post‐vaccination follow‐up until 2022, 17 high‐grade squamous intraepithelial lesion (HSIL) and 15 low‐grade (LSIL) cases were identified at the 25‐year screening round, alongside 371 age and community‐matched HPV16/18‐vaccinated controls. Methylation analyses were performed on cervical samples collected at age 25, preceding histologically confirmed LSIL or HSIL diagnoses. DNA methylation of viral (HPV16/18/31/33) and host‐cell genes (EPB41L3, FAM19A4, and miR124‐2) was measured, along with HPV‐genotyping. No HPV16/18 HSIL cases were observed. The predominant HPV‐genotypes were HPV52 (29.4%), HPV59/HPV51/HPV58 (each 23.5%), and HPV33 (17.7%). Methylation levels were generally low, with no significant differences in mean methylation levels of viral or host‐cell genes between the LSIL/HSIL and controls. However, a significant difference in methylation levels was found between HSIL cases and controls when considering a combination of viral genes and EPB41L3 (p value = .0001). HPV‐vaccinated women with HSIL had HPV infections with uncommon HPV types that very rarely cause cancer and displayed low methylation levels. Further investigation is warranted to understand the likely regressive nature of HSIL among HPV‐vaccinated women and its implications for management.