bluuebunny/crossref_metadata_2025_split huggingface dataset:
Redefining the Wilhelmy and Young equations to imaginary number space and implications for wettability measurements
Authors: Jennissen H. P. 
Published: December 2011

AbstractAlthough Wilhelmy balance measurements have been reported to yield undefined values of the type cos θ > 1, this phenomenon often goes unnoticed because commercial instruments fail to report this error, listing a contact angle of zero instead. On rough superhydrophilic surfaces such “undefined” values appear much more frequent, but a mathematical framework for evaluation and quantification is lacking. A solution to the problem of cos θ > 1 was found by implementing the imaginary number i. It will be shown that both the classical and novel contact angles can be described by numbers in an imaginary space hitherto not accessible to the Wilhelmy and Young equation system. It will be exemplified that Wilhelmy balance data classed as undefined because of cos θ > 1, can easily be converted to imaginary numbers allowing the extrapolation of a novel imaginary advancing θai,AH2O = 0.36i rad and receding contact angle θai,RH2O = 0.37i rad at zero immersion depth as in classical tensiometry. The two imaginary angles compare to classical angles of ∣20°∣–∣25°∣ . The postulated core wettability range for superhydrophilicity in the special case of the “inverse lotus effect” is suggested to extend from the classical angle of cos (10°) to the imaginary angle of cos (0.37i rad). Knowledge obtained from such analyses should be of use in constructing novel artificial surfaces of extreme wettability, e. g. superhydrophilicity, not only in the medical field of implantology but also in chemistry, physics and engineering.
Quantitative MR estimates of blood oxygenation based on T2*: A numerical study of the impact of model assumptions
Authors: Christen Thomas , Zaharchuk Greg , Pannetier Nicolas , Serduc Raphaël , Joudiou Nicolas , Vial Jean‐Claude , Rémy Chantal , Barbier Emmanuel L. 
Published: December 2011

AbstractSeveral MR methods have been proposed over the last decade to obtain quantitative estimates of the tissue blood oxygen saturation (StO2) using a quantification of the blood oxygen level dependent effect. These approaches are all based on mathematical models describing the time evolution of the MR signal in biological tissues in the presence of magnetic field inhomogeneities. Although the experimental results are very encouraging, possible biases induced by the model assumptions have not been extensively studied. In this study, a numerical approach was used to examine the influence on T2*, blood volume fraction, and StO2 estimates of possible confounding factors such as water diffusion, intravascular signal, and presence of arterial blood in the voxel. To evaluate the impact of the vessel geometry, straight cylinders and realistic data from two‐photon microscopy for microvascular geometry were compared. Our results indicate that the models are sufficiently realistic, based on a good correlation between ground truth and MR estimates of StO2. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.
Improved encoding strategy for CPMG‐based Bloch‐Siegert B mapping
Authors: Sturm V. J. F. , Basse‐Lüsebrink T. C. , Kampf T. , Stoll G. , Jakob P. M. 
Published: December 2011

AbstractBloch‐Siegert (BS) based B mapping methods use off‐resonant pulses to encode quantitative B information into the signal phase. It was recently shown that the principle behind BS‐based B mapping can be expanded from spin echo (BS‐SE) and gradient‐echo (BS‐FLASH) based BS B mapping to methods such as Carr, Purcell, Meiboom, Gill (CPMG)‐based turbo‐spin echo (BS‐CPMG‐TSE) and multi‐spin echo (BS‐CPMG‐MSE) imaging. If CPMG conditions are preserved, BS‐CPMG‐TSE allows fast acquisition of the B information and BS‐CPMG‐MSE enables simultaneous mapping of B, M0, and T2. To date, however, two separate MRI experiments must be performed to enable the calculation of B maps. This study investigated a modified encoding strategy for CPMG BS‐based methods to overcome this limitation. By applying a “bipolar” off‐resonant BS pulse before the refocusing pulse train, the needed phase information was able to be encoded into different echo images of one echo train. Thus, this technique allowed simultaneous B and T2 mapping in a single BS‐CPMG‐MSE experiment. To allow single‐shot B mapping, this method was also applied to turbo‐spin echo imaging. Furthermore, the presented modification intrinsically minimizes phase‐based image artifacts in BS‐CPMG‐TSE experiments. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.
Altered β‐adrenergic response in mice lacking myotonic dystrophy protein kinase
Authors: Llagostera Esther , Jesús Álvarez López María , Scimia Cecilia , Catalucci Daniele , Párrizas Marcelina , Ruiz‐Lozano Pilar , Kaliman Perla 
Published: December 2011

AbstractThe protein kinase product of the gene mutated in myotonic dystrophy 1 (DMPK) is reported to play a role in cardiac pathophysiology. To gain insight into the molecular mechanisms modulated by DMPK, we characterize the impact of DMPK ablation in the context of cardiac β‐adrenergic function. Our data demonstrate that DMPK knockout mice present altered β‐agonist–induced responses and suggest that this is due, at least in part, to a reduced density of β1‐adrenergic receptors in cardiac plasma membranes. Muscle Nerve 45: 128–130, 2012
Human muscle fascicle behavior in agonist and antagonist isometric contractions
Authors: Simoneau Emilie M. , Longo Stefano , Seynnes Olivier R. , Narici Marco V. 
Published: December 2011

AbstractIntroduction: The aim of this study was to compare, at a given level of electromyographic (EMG) activity, the behavior of dorsiflexor and plantarflexor muscles as assessed via their architecture (pennation angle and fiber length) during agonist or antagonist isometric contractions. Methods: Real‐time ultrasonography and EMG activity of gastrocnemius medialis (GM) and tibialis anterior (TA) muscles were obtained while young males performed ramp isometric contractions in dorsi‐ and plantarflexion. Results: For both muscles, at a similar level of EMG activity, fiber length was longer, and pennation angle was smaller, during antagonist than during agonist contractions. Conclusions: These results indicate that, at similar levels of EMG activity, GM and TA muscles elicit a higher mechanical output while acting as an antagonist. These findings have important implications for muscle function testing. They show that estimation of antagonistic force using the common method based on the EMG/net torque relationship yields underestimated values. Muscle Nerve 45: 92–99, 2012
Group testing procedures with quantitative features and incomplete identification
Authors: Bar‐Lev Shaul K. , Boxma Onno , Löpker Andreas , Stadje Wolfgang , Van der Duyn Schouten Frank A. 
Published: December 2011

AbstractWe present a group testing model for items characterized by marker random variables. An item is defined to be good (defective) if its marker is below (above) a given threshold. The items can be tested in groups; the goal is to obtain a prespecified number of good items by testing them in optimally sized groups. Besides this group size, the controller has to select a threshold value for the group marker sums, and the target number of groups which by the tests are classified to consist only of good items. These decision variables have to be chosen so as to minimize a cost function, which is a linear combination of the expected number of group tests and an expected penalty for missing the desired number of good items, subject to constraints on the probabilities of misclassifications. We treat two models of this kind: the first one is based on an infinite population size, whereas the second one deals with the case of a finite number of available items. All performance measures are derived in closed form; approximations are also given. Furthermore, we prove monotonicity properties of the components of the objective function and of the constraints. In several examples, we study (i) the dependence of the cost function on the decision variables and (ii) the dependence of the optimal values of the decision variables (group size, group marker threshold, and stopping rule for groups classified as clean) and of the target functionals (optimal expected number of tests, optimal expected penalty, and minimal expected cost) on the system parameters.© 2011 Wiley Periodicals, Inc. Naval Research Logistics, 2011
BRCA1 is an essential mediator of vinorelbine‐induced apoptosis in mesothelioma
Authors: Busacca Sara , Sheaff Michael , Arthur Kenneth , Gray Steven G , O'Byrne Kenneth J , Richard Derek J , Soltermann Alex , Opitz Isabelle , Pass Harvey , Harkin D Paul , Quinn Jennifer E , Fennell Dean A 
Published: December 2011

AbstractThe rapeutic options for malignant pleural mesothelioma (MPM) are limited despite the increasing incidence globally. The vinca alkaloid vinorelbine exhibits clinical activity; however, to date, treatment optimization has not been achieved using biomarkers. BRCA1 regulates sensitivity to microtubule poisons; however, its role in regulating vinorelbine‐induced apoptosis in mesothelioma is unknown. Here we demonstrate that BRCA1 plays an essential role in mediating vinorelbine‐induced apoptosis, as evidenced by (1) the strong correlation between vinorelbine sensitivity and BRCA1 expression level; (2) induction of resistance to vinorelbine by BRCA1 using siRNA oligonucleotides; (3) dramatic down‐regulation of BRCA1 following selection for vinorelbine resistance; and (4) the re‐activation of vinorelbine‐induced apoptosis following re‐expression of BRCA1 in resistant cells. To determine whether loss of BRCA1 expression in mesothelioma was potentially relevant in vivo, BRCA1 immunohistochemistry was subsequently performed on 144 primary mesothelioma specimens. Loss of BRCA1 protein expression was identified in 38.9% of samples. Together, these data suggest that BRCA1 plays a critical role in mediating apoptosis by vinorelbine in mesothelioma, warranting its clinical evaluation as a predictive biomarker. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
The strange case of the lost NRAS mutation in a child with juvenile myelomonocytic leukemia
Authors: De Filippi Paola , Zecca Marco , Novara Francesca , Lisini Daniela , Maserati Emanuela , Pasquali Francesco , Rosti Vittorio , Carlo‐Stella Carmelo , Zavras Niki , Cagioni Claudia , Zuffardi Orsetta , Pagliara Daria , Danesino Cesare , Locatelli Franco 
Published: December 2011

AbstractJuvenile myelomonocytic leukemia (JMML) is a rare myelodysplastic/myeloproliferative disorder of early childhood characterized by mutations of the RAS‐RAF‐MAP kinase signaling pathway. We report the case of a child with a diagnosis of JMML carrying two mutations of NRAS gene (c.37G>C and c.38G>A) independently occurring in long‐term culture initiating cells. However, only the former was consistently found in more mature hematopoietic cells, suggesting that cancer transformation may lead to the loss of a mutation. This case also indicates that molecular analysis on cell types other than peripheral blood leukocytes may be useful to obtain relevant biological information on JMML pathogenesis. Pediatr Blood Cancer 2012;59:580–582. © 2011 Wiley Periodicals, Inc.
Leukapheresis in children weighing less than 20 kg
Authors: Sauer Harald , Roland Haase , Ulla Lieser , Ortrud Diwan , Jürgen Föll 
Published: December 2011

AbstractAugmentation of standard chemotherapy with peripheral blood stem cells (PBSC) rescue is a standard treatment strategy. However, in pediatric patients weighing less than 20 kg, the collection of PBSC presents a challenge. We report our experience with nine pediatric patients weighing between 4.33 and 19.9 kg and a total of 23 PBSC collection aphereses. None of our patients experienced any major complications. We conclude that PBSC apheresis in children is a safe method. It should be based on a standardized procedure that includes the determination of clinical and laboratory parameters and appropriate monitoring. Pediatr Blood Cancer 2012; 58: 627–629. © 2011 Wiley Periodicals, Inc.
Video self‐modeling to improve academic performance: A literature review
Authors: Prater Mary Anne , Carter Nari , Hitchcock Caryl , Dowrick Peter 
Published: December 2011

AbstractVideo self‐modeling (VSM) has been used for decades to effectively improve individuals' behaviors and skills. The purpose of this review is to locate and analyze published studies that used VSM for typical school‐based academic skills to determine the effect of VSM interventions on students' academic performance. Only eight studies were located that met the selection criteria. Based on the results of these 8 studies, VSM shows promise for improving academic performance, although the small number of studies limits our ability to draw strong conclusions about the efficacy of VSM across the school age span and across various academic skills. © 2011 Wiley Periodicals, Inc.
Video self‐modeling
Authors: Buggey Tom , Ogle Lindsey 
Published: December 2011

AbstractVideo self‐modeling (VSM) first appeared on the psychology and education stage in the early 1970s. The practical applications of VSM were limited by lack of access to tools for editing video, which is necessary for almost all self‐modeling videos. Thus, VSM remained in the research domain until the advent of camcorders and VCR/DVD players and, more recently, video‐editing software. In this article, the authors trace the history and development of VSM, summarize the research, and provide suggestions for future directions. © 2011 Wiley Periodicals, Inc.
Erratum: A life cycle framework for the investigation of environmentally benign nanoparticles and products [Phys. Status Solidi RRL 5, No. 9, 312–317 (2011)]
Authors: Theis Thomas L. , Bakshi Bhavik R. , Durham Delcie , Fthenakis Vasilis M. , Gutowski Timothy G. , Isaacs Jacqueline A. , Seager Thomas , Wiesner Mark R. 
Published: December 2011

AbstractThe name of a further author and contributor to this work, Roland Clift, has been added to the author list of the article in agreement with all co‐authors. It had been inadvertently omitted from the original version of the paper (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Creativity and Organizational Learning as Means to Foster Sustainability
Authors: Lozano Rodrigo 
Published: December 2011

ABSTRACTThis article argues that creativity and organizational learning can help to challenge the traditional Newtonian and Cartesian mental models and foster more sustainable societies. The recognition and acceptance of creativity by individuals, groups, organizations, and finally society can create new knowledge and metanoia. Creativity helps to break through the knowledge barrier of current reductionist mental models, while learning helps to consolidate and institutionalize the new mental models. This is especially the case where learning questions underlying assumptions and develops new theories and methodologies that constantly challenge the status quo for the present and the future, instead of mere reaction to immediate problems. Eventually, these mental models would need to be questioned by future creative thinkers in a continuous process; hence, solving today's problems with tomorrow's ideas, and ensuring progress towards more sustainable societies. The paper takes the example of Gaia theory to illustrate how creativity can be institutionalized. Copyright © 2011 John Wiley & Sons, Ltd and ERP Environment
Comparison of nonlinear behavior of steel moment frames accompanied with RC shear walls or steel bracings
Authors: Esmaeili Hamed , Kheyroddin Ali , Kafi Mohammad Ali , Nikbakht Hamed 
Published: December 2011

SUMMARYIn this paper, the seismic behavior of dual structural systems in forms of steel moment‐resisting frames accompanied with reinforced concrete shear walls and steel moment‐resisting frames accompanied with concentrically braced frames, have been studied. The nonlinear behavior of the mentioned structural systems has been evaluated as, in earthquakes, structures usually enter into an inelastic behavior stage and, hence, the applied energy to the structures will be dissipated. As a result, some parameters such as ductility factor of structure (μ), over‐strength factor (Rs) and response modification factor (R) for the mentioned structures have been under assessment. To achieve these objectives, 30‐story buildings containing such structural systems were used to perform the pushover analyses having different load patterns. Analytical results show that the steel moment‐resisting frames accompanied with reinforced concrete shear walls system has higher ductility and response modification factor than the other one, and so, it is observed to achieve suitable seismic performance; using the first system can have more advantages than the second one. Copyright © 2011 John Wiley & Sons, Ltd.
Nonlinear dynamic response of tall buildings considering structure–soil–structure effects
Authors: Nateghi‐A Fariborz , Rezaei‐Tabrizi Ali 
Published: December 2011

SUMMARYNumerous studies have shown that the interaction between adjacent buildings can result in changes in nonlinear dynamic response of structures, damage, and performance level, depending on the dynamic specifications of structures involved and the frequency content of the input motion.To study these effects, finite element method is used for the analytical investigations, and total soil–foundation–structure system is modeled all together. For modeling purposes and in order to realize the effects of the adjacent buildings on the dynamic response, two buildings, namely, 15‐story and 30‐story tall buildings, which were separated by distances of 1/4 and 1/8 of the width of the foundation and were located on hard and soft soil profiles, were considered.It was concluded that in the case where the soil and structure's periods were near to each other, the interaction of adjacent structures on increasing nonlinear responses (displacement and interstory drift) and structural damage indexes was noticeable and therefore was not negligible. Whereas in the case where periods are distant from each other, the interaction of adjacent buildings has a decreasing effect on damage indexes and nonlinear responses and therefore was negligible. Copyright © 2011 John Wiley & Sons, Ltd.
Heterometallic Polynuclear Complexes of Macrocyclic ­Oxamide with Pyrazine‐2, 3‐dicarboxylic Acid: Synthesis, Crystal Structure, and Magnetic Properties
Authors: Sun Ya‐Qiu , Wu Lin , Fan Lan‐Lan , Zhang Guo‐Ying , Xu Yan‐Yan , Gao Dong‐Zhao 
Published: December 2011

AbstractThree novel complexes, namely [Zn(CuL)(pzdc)]2·5H2O (1), [Zn(NiL)(pzdc)]2·5H2O (2), and [Gd2(pzdc)2(NiL)6](ClO4)2·6H2O (3) (CuL and NiL, H2L = 2, 3‐dioxo‐5, 6, 14, 15‐dibenzo‐1, 4, 8, 12‐tetraazacyclo‐pentadeca‐7, 13‐dien and H2pzdc = pyrazine‐2, 3‐dicarboxylic acid) were synthesized and structurally determined. Complexes 1 and 2 are tetranuclear [ZnII2MII2] (M = Ni (1), Cu (2), respectively) molecules including both oxamide and pzdc2– bridges. The structure of compound 3 consists of pyrazine‐2, 3‐dicarboxylate and oxamido‐bridged, and is arranged in different butterfly‐like octanuclear molecules. The magnetic susceptibility data of 3 were analyzed.
Synthesis, Characterization, and Thermostability of Four Novel Cadmium(II) Coordination Polymers with Mixed Ligands
Authors: Li Ming‐Tian , Wang Cheng‐Gang , Yu Lan‐Ying , Yang Rui‐Song 
Published: December 2011

Abstract Four novel mixed‐ligand complexes were obtained from the reaction of maleic acid, diimine chelating ligands and Cd(OH)2 or CdO in a mixed solvent of water and methanol. The complexes were characterized by IR spectroscopy, elemental analysis, and single‐crystal X‐ray diffraction. The results show that all the four complexes are coordination polymers. [Cd(phen)(H2O)(male)]n·2nH2O (1) and [Cd(bipy)(H2O)(male)]n·2nH2O (2) (male = maleate; phen = 1, 10‐phenanthroline, bipy = 2, 2′‐bipyridine) are isomorphic, and the asymmetric unit is constructed by one CdII atom, a maleate group, a diimine ligand and two crystal water molecules. Each maleate group links two CdII atoms in a bis(bidentate) chelating mode, resulting in a 1D helical chain. Within [Cd(phen)(H2O)2(male)]n·2nH2O (3), the maleate group bridges two CdII atoms in a bis(monodentate) chelating mode into a 1D helical chain along the [100] direction. The helical chain is decorated by phen groups alternatively at the two sides, and each phen plane of one chain is inserted in the void space between two adjacent phen ligands from an adjacent chain, resulting in a double zipper‐like chain. The asymmetric unit of [Cd2(phen)2(male)2]n (4) contains a CdII cation, one phen molecule, and a maleate group, and one bridging maleate group links three CdII atoms resulting in a 2D layer extending in [011] plane. The 2D networks are constructed by four kinds of rings formed by the central metal atom and maleate dianion. The thermostabilities of the four complexes were investigated.
Newborn screening for lysosomal storage diseases: an ethical and policy analysis
Authors: Ross Lainie Friedman 
Published: December 2011

AbstractThe traditional focus of newborn screening (NBS) is testing infants for medical conditions like phenylketonuria (PKU) that may cause significant morbidity or mortality unless treatment is initiated early. Although the Wilson and Jungner criteria were not designed specifically for NBS, the public health screening criteria have been used, with some modifications, to justify what conditions are included in a universal NBS panel. These criteria are being challenged by platform technologies like tandem mass spectrometry (MS/MS) that allow for the identification of numerous conditions on a single sample because they identify many conditions and variants simultaneously, some of which meet and others which fail to meet the criteria. In this manuscript, I evaluate three lysosomal storage diseases included in this multiplex screening test—Pompe disease, Fabry disease, and Krabbe disease. I show that they fail to meet some of the critical Wilson and Jungner criteria and thus are not ready for inclusion in universal NBS panels. Rather, screening for these conditions should only be performed in the research context with institutional review board approval and parental permission.
What is a “Balanced” Description? Insight from Parents of Individuals with Down Syndrome
Authors: Hippman Catriona , Inglis Angela , Austin Jehannine 
Published: December 2011

AbstractGenetic counselors and parents of individuals with Down syndrome (DS) agree that descriptions of DS in prenatal settings should be “balanced.” However, there is no consensus regarding what constitutes a balanced description of DS. A survey was designed in collaboration with, and sent to the membership of, the British Columbia based Lower Mainland Down Syndrome Society (N = 260). Respondents were asked how they would describe DS to a couple who have just received a prenatal diagnosis of the condition. We rated the descriptions provided for positivity/negativity. Completed surveys were returned by 101 members, the majority of whom were Caucasian (87%) and female (79%). Participants’ descriptions of DS ranged from entirely positive (n = 5; 10%) to entirely negative (n = 4; 7%) in nature. Deriving a description of DS that would broadly be perceived as “balanced” may be impossible. Instead, it may be more important to explore the range of possibilities regarding the family experience of raising a child with DS using nonjudgmental terminology, and to help families evaluate these possibilities in the context of their own values, coping strategies, and support networks.