bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nuclear localization of E‐cadherin but not beta‐catenin in human ovarian granulosa cell tumours and normal ovarian follicles and ovarian stroma
Authors: Ohishi Yoshihiro , Oda Yoshinao , Kurihara Shuichi , Kaku Tsunehisa , Kobayashi Hiroaki , Wake Norio , Tsuneyoshi Masazumi 
Published: February 2011

Ohishi Y, Oda Y, Kurihara S, Kaku T, Kobayashi H, Wake N & Tsuneyoshi M (2011) Histopathology58, 423–432 Nuclear localization of E‐cadherin but not beta‐catenin in human ovarian granulosa cell tumours and normal ovarian follicles and ovarian stromaAims:  The role of misregulated Wnt/beta‐catenin signalling in human ovarian granulosa cell tumour (GCT) has not been well characterized. The aim of this study was to confirm subcellular localization of key molecules of Wnt signalling (beta‐catenin and E‐cadherin) in human ovarian GCTs.Methods and results:  Tissue samples taken from 32 human ovarian GCTs and 19 human normal ovaries containing 68 follicles were stained immunohistochemically using monoclonal anti‐beta‐catenin and anti‐E‐cadherin antibodies. None of the 32 GCTs and none of the 68 ovarian follicles showed beta‐catenin nuclear expression (0%). On the other hand, 28 of 32 GCTs (88%) and 53 of 68 normal ovarian follicles (78%) showed nuclear expression of E‐cadherin in granulosa cells. The ovarian stroma in all 19 normal ovaries showed nuclear expression of E‐cadherin but not beta‐catenin. Membranous and cytoplasmic expression was observed variously in ovarian GCT, follicles and stroma.Conclusions:  We have confirmed frequent nuclear localization of E‐cadherin but not beta‐catenin in human ovarian GCT, ovarian follicles and stroma. There is no evidence of misregulated Wnt/beta‐catenin signalling (represented by nuclear expression of beta‐catenin) in human ovarian GCT. Nuclear translocation of E‐cadherin might contribute to ovarian folliculogenesis or granulosa/stromal cell differentiation.
Retracted: A randomised controlled study of the effects of music on sleep quality in older people
Authors: Chan Moon Fai 
Published: February 2011

Aim.  To determine the effect of music on sleep quality in older people.Background.  Sleep disturbance is common in older people and its impacts on older adults along with its conventional treatment merit our attention as our population ages. Conventional pharmacological method might result dependence and impairment in psychomotor and cognitive function. Listening to music, which is a non‐pharmacological method, might promote relaxation, induce distraction responses and promote sleep quality.Design.  A randomised controlled study.Methods.  The study was conducted from December 2006–January 2007. Forty‐two older people (21 using music and 21 controls) completed the study in Hong Kong. Physiological (blood pressure and heart rate) and sleep quality variables were collected once a week for one month.Results.  For all vital signs’ results, no significant differences were found between both music and control groups within the four weeks. In the music group, there was statistically significant reduction in sleep scores at week 4. In control group, there was no statistically significant improvement of sleep scores in the four weeks. However, no significant difference was found between groups over the four weeks.Conclusion.  Whilst there were no statistical differences between groups, there was some indication that music yielder higher improvement on sleep scores, which are worthier of further investigation in larger trials.Relevance to clinical practice.  The implication of this study is that music listening can help nurses build therapeutic relationships with older people. Nurses are recommended to use music as part of their holistic caring for older people.
The relationships between uncertainty and its antecedents in Korean patients with atrial fibrillation
Authors: Kang Younhee 
Published: February 2011

Objectives.  The aim of the study was to examine the relationships between uncertainty and its antecedents, including education, social support and symptom frequency in Korean patients with atrial fibrillation.Background.  The antecedents of uncertainty were theoretically identified from Mishel’s theory of uncertainty in illness. There is a need to examine empirically whether theoretically driven antecedents of uncertainty work in a way that the theory proposed.Design.  Descriptive correlational and cross‐sectional survey design.Methods.  Subjects were interviewed using structured study questionnaires. The data collected were statistically analysed by descriptive statistics and hierarchical regression analysis to determine the effects of antecedents on uncertainty.Results.  A convenience sample of 109 subjects recruited from three academic medical centres in South Korea. The overall model significantly explained 20·1% of the variance in uncertainty. Among antecedents of uncertainty, social support was significantly associated with less uncertainty (β = −0·26), while the education was not associated with uncertainty. Persons with greater social supports perceived less uncertainty, and individuals with greater symptom frequency reported greater uncertainty (β = 0·21).Conclusions.  In Korean patients with atrial fibrillation, it was demonstrated that uncertainty in atrial fibrillation patients was predicted by social support and symptom frequency. Thus, the nursing strategies that reduce uncertainty which results in undesirable outcomes are required through maximising the social support patients perceived and minimising the symptom frequency. Therefore, these findings are relevant to clinical nurses who take care of patients with atrial fibrillation in terms of decreasing uncertainty that might result in patients’ psychological distress.Relevance to clinical practice.  The findings from this study may be beneficial for clinical nurses to understand and assess the psychosocial and emotional needs of patients with atrial fibrillation.
Inhibitory activity of Pseudomonas sp. on Flavobacterium psychrophilum, in vitro
Authors: Ström‐Bestor M , Wiklund T 
Published: February 2011

AbstractA Pseudomonas sp. isolate MSB1 efficiently inhibited the growth of Flavobacterium psychrophilum of different serotypes on agar medium. A significant difference in the inhibition was observed between isolates of the less virulent FpT serotype compared to the Fd and Th serotypes. In broth coculture experiments, a low number of cells of MSB1 inhibited and outcompeted the F. psychrophilum cells. Also cell‐free culture supernatant of MSB1 clearly repressed the growth of F. psychrophilum. A chromoazurol S assay suggested that MSB1 produced efficient siderophores, which most probably were responsible for the iron deficiency in the supernatant. The limited growth of F. psychrophilum in the supernatant was found to be partly because of the lack of available iron, but the results also indicated that some other mechanisms were probably involved in the observed inhibition. A potential use of MSB1 as a probiotic in rainbow trout aquaculture, especially in early life stages of the fish, is suggested, but future in vivo experiments needs to be carried out to verify this suggestion. This study also indicates a low iron acquisition efficiency of F. psychrophilum, compared to other examined bacterial fish pathogens.
A comparative study of marine salmonid alphavirus subtypes 1–6 using an experimental cohabitation challenge model
Authors: Graham D A , Frost P , McLaughlin K , Rowley H M , Gabestad I , Gordon A , McLoughlin M F 
Published: February 2011

AbstractA comparative challenge study of six marine isolates representing subtypes 1–6 of salmonid alphavirus (salmon pancreas disease virus, Genus Alphavirus, Family Togaviridae) was conducted in Atlantic salmon in a fresh water cohabitation trial. Histopathological lesions typical of pancreas disease were observed with all subtypes, and virus was re‐isolated from serum of cohabitant fish in each case. Using a virus neutralization (VN) test neutralizing salmonid alphavirus (SAV) subtype 1 strain F93‐125, VN antibodies were detected in all challenge groups, consistent with serological cross‐reactivity between these subtypes. Using real‐time RT‐PCR, SAV RNA was detected in heart tissue from 2 to 3 weeks post‐challenge (wpc) in all cohabitant groups excluding controls. The results obtained suggested differences in the dynamics of infection between strains of SAV and potentially between subtypes. Results for SAV subtypes 1 and 3 suggested essentially synchronous infection of cohabitant fish. These two study groups also had the highest virus load in heart tissue as measured by quantitative RT‐PCR and also had the most extensive histopathological changes. In contrast, results for SAV subtypes 2 and 6 strains were consistent with asynchronous infection in the cohabitant fish and were characterized by slow spread, low virus loads and mild histopathological changes. The SAV subtype 4 and 5 strains occupied an intermediate position in this regard. Despite the use of concentration procedures, it was not possible to detect SAV RNA in water samples from selected study tanks. However, testing of faeces from the SAV subtypes 1, 3 and 6 challenge groups found positive signals in each beginning at 1–3 wpc and remaining detectable for a further 2–3 weeks. Parallel testing of mucus samples found these became positive at 2–3 wpc and remained positive for a further 1–3 weeks. These results demonstrate for the first time that shedding and transmission of virus may occur by both these routes and suggest that dispersal in these matrices should be included in any disease transmission models.
Potential for evolutionary coupling and decoupling of larval and adult immune gene expression
Authors: FELLOUS SIMON , LAZZARO BRIAN P. 
Published: February 2011

AbstractAlmost all studies of the immune system of animals with metamorphosis have focused on either larval or on adult immunity, implicitly assuming that these traits are either perfectly correlated or evolutionarily independent. In this study, we use 80 crosses among 21 Drosophila melanogaster lines to investigate the degree and constancy of genetic correlation in immune system activity between larvae and adults. The constitutive transcription of Diptericin, a gene encoding a defensive antimicrobial peptide, was controlled by the same genetic factors in larvae and adults, with variation in expression determined exclusively by nonadditive genetic effects. This contrasted with another peptide‐encoding gene, Drosomycin, in which larval transcription was highly variable and determined by additive effects but adult transcription genetically invariant. We found no evidence for a fitness cost to the transcription of these genes in our study. The shared genetic control of larval and adult Diptericin transcription stands in contrast to predictions of the adaptive decoupling hypothesis, which states that distinct life‐stages should permit the independent evolution of larval and adult phenotypes. Importantly, genetic correlations between larval and adult immunities imply that parasite pressure on one life‐stage can drive the evolution of immunity (and resistance) in the other life‐stage.
Genome‐wide atlas of transcription during maize development
Authors: Sekhon Rajandeep S. , Lin Haining , Childs Kevin L. , Hansey Candice N. , Buell C. Robin , de Leon Natalia , Kaeppler Shawn M. 
Published: February 2011

SummaryMaize is an important model species and a major constituent of human and animal diets. It has also emerged as a potential feedstock and model system for bioenergy research due to recent worldwide interest in developing plant biomass‐based, carbon‐neutral liquid fuels. To understand how the underlying genome sequence results in specific plant phenotypes, information on the temporal and spatial transcription patterns of genes is crucial. Here we present a comprehensive atlas of global transcription profiles across developmental stages and plant organs. We used a NimbleGen microarray containing 80 301 probe sets to profile transcription patterns in 60 distinct tissues representing 11 major organ systems of inbred line B73. Of the 30 892 probe sets representing the filtered B73 gene models, 91.4% were expressed in at least one tissue. Interestingly, 44.5% of the probe sets were expressed in all tissues, indicating a substantial overlap of gene expression among plant organs. Clustering of maize tissues based on global gene expression profiles resulted in formation of groups of biologically related tissues. We utilized this dataset to examine the expression of genes that encode enzymes in the lignin biosynthetic pathway, and found that expansion of distinct gene families was accompanied by divergent, tissue‐specific transcription patterns of the paralogs. This comprehensive expression atlas represents a valuable resource for gene discovery and functional characterization in maize.
Environmental improvement of seafood through certification and ecolabelling: theory and analysis
Authors: Tlusty Michael F 
Published: February 2011

AbstractThe study of environmental impacts of seafood production as a result of ecolabelling and certification is a young yet rapidly growing discipline that lacks theoretical models. Pieces of the model have been suggested in the literature, and these pieces are formalized here realizing the current operating parameters of the global seafood industry. The derived pull‐threshold model assumes that if producers exceed the threshold, there is no incentive to improve while if too far below, improvement is most likely beyond technical or financial means. Thus, a single certification is only a marginal solution to the larger picture. Those producers immediately below the certification threshold are within range or ‘pull’ of the threshold to improve as a result of certification. Results from a single threshold model applied to compliance data indicated that a maximum improvement of 12.5%, achieved when the pull was the greatest and the threshold was at the lower end of the impact distribution. When impacts were continuous (e.g. escapes in aquaculture), greater improvement was observed with thresholds targeting the producers at the higher end of the impact distribution. In all cases, improvement was maximized with a triple threshold model, indicating that single threshold scenario will not drive the greatest movement towards environmental improvement throughout the industry. Innovation is potentially more important in reducing environmental impacts of seafood production and needs to be accounted for as the seafood certification or ecolabelling continues to mature.
Rights‐based fisheries governance: from fishing rights to human rights
Authors: Allison Edward H , Ratner Blake D , Åsgård Björn , Willmann Rolf , Pomeroy Robert , Kurien John 
Published: February 2011

AbstractIn the last twenty years, policy prescriptions for addressing the global crisis in fisheries have centred on strengthening fisheries governance through clarifying exclusive individual or community rights of access to fishery resources. With a focus on small‐scale developing‐country fisheries in particular, we argue that basing the case for fishery governance reform on assumed economic incentives for resource stewardship is insufficient when there are other sources of insecurity in people’s lives that are unrelated to the state of fishery resources. We argue that more secure, less vulnerable fishers make more effective and motivated fishery managers in the context of participatory or rights‐based fisheries governance, and we further suggest that insecurity among fishers living in poverty can be most effectively addressed by social and political development that invokes the existing legal framework supporting the Universal Declaration of Human Rights. This perspective goes well beyond the widely advocated notion of ‘rights‐based fishing’ and aligns what fishery sector analysts call the ‘rights‐based approach’ with the same terminology used in the context of international development. Embedding the fisheries governance challenge within a broader perspective of human rights enhances the chances of achieving both human development and resource sustainability outcomes in small‐scale fisheries of developing countries.
Anxious Attachment and Relationship Processes: An Interactionist Perspective
Authors: Campbell Lorne , Marshall Tara 
Published: February 2011

AbstractRelationship processes in adult romantic relationships have been vastly studied under the aegis of attachment theory. Attachment theory is interactionist in nature, proposing that individual differences in levels of both attachment avoidance and anxiety predict an individual's thoughts, feelings, and behaviors in contexts that activate attachment concerns. A growing body of research is beginning to systematically test the conditions in which individual differences in attachment orientations both predict and fail to predict relationship processes. In this article, we focus on anxious attachment and review a program of research showing that the potentially destructive relationship processes typically observed in highly anxious individuals do not always appear in neutral or benign contexts, or when security needs are met. We argue that research needs to more thoroughly investigate the conditions that should, or should not, activate attachment concerns and thus result in links between individual differences in attachment orientations and relationship processes.
Conciliatory Gestures Facilitate Forgiveness and Feelings of Friendship by Making Transgressors Appear More Agreeable
Authors: Tabak Benjamin A. , McCullough Michael E. , Luna Lindsey R. , Bono Giacomo , Berry Jack W. 
Published: February 2011

AbstractThe authors examined how conciliatory gestures exhibited in response to interpersonal transgressions influence forgiveness and feelings of friendship with the transgressor. In Study 1, 163 undergraduates who had recently been harmed were examined longitudinally. Conciliatory gestures exhibited by transgressors predicted higher rates of forgiveness over 21 days, and this relationship was mediated by victims’ perceptions of their transgressors’ Agreeableness. Study 2 was an experiment including 145 undergraduates who experienced a breach in trust from an anonymous partner during an iterated prisoner's dilemma. When transgressors apologized and offered financial compensation, participants reported higher levels of forgiveness and feelings of friendship when compared to a control condition and an aggravating condition. The effects of apology/compensation on forgiveness and perceived friendship were mediated by victims’ perceptions of their transgressors’ Agreeableness. Results suggest that conciliatory gestures promote forgiveness in part by depicting transgressors as more sympathetic, considerate, fair, and just (i.e., agreeable).
Scale Space Meshing of Raw Data Point Sets
Authors: Digne Julie , Morel Jean‐Michel , Souzani Charyar‐Mehdi , Lartigue Claire 
Published: February 2011

AbstractThis paper develops a scale space strategy for orienting and meshing exactly and completely a raw point set. The scale space is based on the intrinsic heat equation, also called mean curvature motion (MCM). A simple iterative scheme implementing MCM directly on the raw point set is described, and a mathematical proof of its consistency with MCM is given. Points evolved by this MCM implementation can be trivially backtracked to their initial raw position. Therefore, both the orientation and mesh of the data point set obtained at a smooth scale can be transported back on the original. The gain in visual accuracy is demonstrated on archaeological objects by comparison with several state of the art meshing methods.
Actions speak louder than words: the embodiment of trust by healthcare professionals in gynae‐oncology
Authors: Brown Patrick R. , Alaszewski Andy , Swift Trish , Nordin Andy 
Published: February 2011

AbstractTrust is vital for quality healthcare outcomes, yet existing research neglects the ‘embodiedness’ of the interactions on which trust is based. This article draws on qualitative data from semi‐structured interviews with cervical cancer patients. The significance of body work in winning or, on occasions, undermining trust emerged as a key theme within the responses. Interpretations of professionals’ verbal and non‐verbal presentations‐of‐self were often mutually reinforcing and intrinsically linked – forming a more general locus of meaning from which assumptions of competence and care were drawn. Yet it also became apparent that, whilst verbal communication was useful in establishing the agenda of the professional in relation to that of the patient, it was body work which was crucial in corroborating and validating beliefs pertaining to the ability and willingness of the professional to deliver this agenda in the future. The multi‐temporal nature of trust makes apparent how certain seemingly distinct forms of body work – as presentation‐of‐self versus more hands‐on modes – are inherently intertwined. Trust, and the affective relationship in which it is rooted, bridges the present with the future and thus makes apparent how seemingly ‘detached’ forms of body work are connected to the emotion‐work of the caring role and the craftwork of body work as touch.
Time, space and touch at work: body work and labour process (re)organisation
Authors: Cohen Rachel Lara 
Published: February 2011

AbstractWith ‘efficiency savings’ the watchword for health and social care services, reorganisation and labour rationalisation are the order of the day. This article examines the difficulties involved in (re)organising work which takes bodies as its object, or material of production. It shows that working on bodies (‘body work’) systematically delimits possibilities for labour process rationalisation which, in turn, constrains reorganisation of the health and social care sector. It does this in three main ways. First: rigidity in the ratio of workers to bodies‐worked‐upon limits the potential to increase capital‐labour ratios or cut labour. Secondly: the requirement for co‐presence and temporal unpredictability in demand for body work diminish the spatial and temporal malleability of the labour process. Thirdly: the nature of bodies as a material of production – complex, unitary and responsive – makes it difficult to standardise, reorganise or rationalise work. A wide‐ranging analysis of body work in health and social care, as well as other sectors, fleshes out these three constraints and shows that attempts to overcome them and reorganise the sector in pursuit of cost savings or ‘efficiency’, generate problems for workers and the patients, whose bodies they work upon.
Managing the body work of home care
Authors: England Kim , Dyck Isabel 
Published: February 2011

AbstractBody work is a key element of home healthcare. Recent restructuring of health and social care services means the home is increasingly a key site of long‐term care. While there is a growing literature on the social dynamics between care recipients and their family caregivers, less is known about the formal work dynamic between paid care workers and care recipients and family caregivers. Drawing on interview data from an Ontario‐based study of long‐term home care, we explore how body work is negotiated through the embodied practices of care in the home and through care relationships associated with home care. In particular we focus on how the practices of intimate body care (such as bathing, toileting, and catheter management) show the diverse dynamics of care work through which caregivers, care recipients and homespace are constituted. We argue that the practices of care are shaped by a complex interweaving of regulatory mechanisms associated with home care along with the physical and affective dimensions of intimate body work. In turn this suggests the need for new ways of understanding body work in contemporary landscapes of care.