bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of pirtobrutinib for relapsed/refractory mantle cell lymphoma in compassionate use program in Europe
Authors: Aydilek Enver , Wulf Gerald , Schwarz Friedrich , Bacher Ulrike , Rummel Mathias , Stiefel Olga , Kerkhoff Andrea , Maulhardt Markus , Melchardt Thomas , Pabst Thomas , Lenz Georg , Shumilov Evgenii 
Published: May 2024

AbstractBackgroundMantle cell lymphoma (MCL) is a type of B‐cell lymphoma that is currently incurable. Pirtobrutinib shows promising response rates in heavily pretreated MCL patients according to the approval study, but the real‐world data are scarce.MethodsIn this study, we retrospectively analyzed the efficacy and safety profile of pirtobrutinib in 10 relapsed/refractory MCL patients from compassionate use program (CUP).ResultsOn average, the patients underwent three lines of systemic therapy prior to pirtobrutinib and were predominantly BTKi exposed (9/10). The best overall response rate (BORR) was 67%. In a median follow‐up of 8.6 months, the mean duration of response (DOR), progression‐free survival (PFS), and overall survival (OS) were not reached. No new safety signals were documented.ConclusionsIn summary, pirtobrutinib represented a safe and effective treatment option in a small real‐world population.
Clinicopathological features, prognostic factor analysis, and survival nomogram of patients with double primary cancers involving lung cancer
Authors: Hao Yuxuan , Zhang Xiaoye , Cui Guoyuan , Qi Xiaoying , Jiang Zhongxiu , Yu Li 
Published: May 2024

AbstractBackgroundAlthough the incidence of double primary cancers (DPCs) involving lung cancer is rising, they have not been studied sufficiently. This study retrospectively analyzed the clinicopathological and prognostic characteristics of DPC patients with lung cancer and developed a survival nomogram to predict the individual OS rates.MethodsWe included 103 DPC patients with lung cancer from Shengjing Hospital between 2016 and 2021. Based on the 6‐month cancer occurrence interval, the cases were categorized as synchronous DPCs (sDPCs) or metachronous DPCs (mDPCs). Furthermore, the mDPCs were subdivided based on whether the lung cancer occurred first (LCF cohort) or the other cancer occurred first (OCF cohort).ResultsAmong the patients, 35 (33.98%) and 68 (66.02%) had sDPCs and mDPCs, respectively. In the mDPCs cohort, 18 (26.47%) belonged to the LCF cohort and 50 (73.53%) to the OCF cohort. The most frequent primary cancer sites were the breast (27.18%), colorectum (22.33%), and urinary system (18.45%). Independent risk factors for progression‐free survival were Stage IV lung cancer (p = 0.008) and failure to undergo radical lung cancer surgery (p = 0.028). The risk factors for OS included squamous carcinoma (p = 0.048), Stage IV lung cancer (p = 0.001), single cancer resection plus drug therapy (p < 0.001), drug therapy alone (p = 0.002), failure to undergo radical lung cancer surgery (p = 0.014), and chemotherapy (p = 0.042). The median OS was 37 months, with 3‐ and 5‐year rates of 50.9% and 35.9%, respectively.ConclusionDPCs involving lung cancer account for 1.11% of cases. The breast, colorectum, and urinary system were the most common extra‐pulmonary sites, and mDPCs were more frequent than sDPCs. Radical lung cancer surgery significantly affects prognosis, and drug therapy alone may be preferable when only one tumor is operable. The developed nomogram can accurately predict individual 3‐year and 5‐year OS rates.
Laburnicolamine: A Rare Penillic Acid Congener from the Nematode Cyst‐Associated Fungus Laburnicola nematophila
Authors: Wennrich Jan‐Peer , Holzenkamp Caren , Ashrafi Samad , Maier Wolfgang , Wang Hao , Ibrahim Mahmoud A. A. , Ebada Sherif S. , Stadler Marc 
Published: May 2024

AbstractA chemical investigation of a methanol extract derived from a solid‐state rice culture of the nematode‐cyst associated fungus Laburnicola nematophila K01 led to the isolation and characterization of a previously undescribed penillic acid analogue named laburnicolamine (1). The chemical structure was elucidated through comprehensive 1D and 2D NMR spectroscopic analyses in methanol‐d4 and DMSO‐d6, alongside with HR‐ESI‐MS spectrometry. The absolute configuration of 1 was concluded through the electronic circular dichroism (ECD) and time‐dependent density functional theory‐ECD (TDDFT‐ECD) computations compared to its acquired spectrum. Biological assays revealed that compound 1 exhibited no significant cytotoxic, antimicrobial, or nematicidal activity.
Electrochemically Enhanced Forward Osmosis Processes Unlocking Efficiency and Versatility
Authors: Yang Euntae , Kim Chang‐Min , Ahmad Ishaq , Jee Hobin , Song Seunghyun , Park Chanwoo , Jung Yudam , Kang Dohyoung , Chae Kyu‐Jung , Kim In S. 
Published: May 2024

AbstractThe growing interest in forward osmosis (FO) for water reclamation and desalination over the past two decades stems from its potential for lower energy consumption. Despite its promise, FO faces significant challenges, such as the lack of an appropriate draw solute, concentration polarization, membrane fouling, and reverse solute flux (RSF). Recent trends in research have focused on combining various technologies with FO to address these challenges. Notably, the integration of electrochemical technologies with FO offers new possibilities. This review covers FO combined with electrochemical cells (FO‐ECs), categorizing them based on their working principles and applications in improving FO. The review discusses different FO‐EC configurations, including (1) electrodialysis‐combined FO for RSF, (2) electro‐FO for water flux enhancement, and (3) electrochemical oxidation‐combined FO and FO with electro‐conductive membranes for self‐cleaning and fouling mitigation. Additionally, it covers (4) reusable electro‐responsive draw solutes, (5) electrochemical osmosis systems for metal removal and energy production, and (6) osmotic microbial fuel cells for energy recovery and other benefits. The review also assesses the practical applicability and potential for achieving carbon neutrality of the FO‐ECs. It concludes with a forward‐looking perspective, outlining future research directions to optimize and expand the use of electrochemical‐enhanced FO technologies.
Synthetic Strategies to Extended Aromatic Covalent Organic Frameworks
Authors: Prieto Tania , Ponte Clara , Guntermann Roman , Medina Dana D. , Salonen Laura M. 
Published: May 2024

Abstractπ‐Conjugated materials are highly attractive owing to their unique optical and electronic properties. Covalent organic frameworks (COFs) offer a great opportunity for precise arrangement of building units in a π‐conjugated crystalline matrix and tuning of the properties through choice of functionalities or post‐synthetic modification. With this review, we aim at summarizing both the most representative as well as emerging strategies for the synthesis of π‐conjugated COFs. We give examples of direct synthesis using large, π‐extended building blocks. COFs featuring fully conjugated linkages such as vinylene, pyrazine, and azole are discussed. Then, post‐synthetic modification methods that result in the extension of the COF π‐system are reviewed. Throughout, mechanistic insights are presented when available. In the context of their utilization as film devices, we conduct a concise survey of the prominent COF layer deposition techniques reported and their aptness for the deposition of fused aromatic systems.
Similarities and Differences of Hydridic and Protonic Hydrogen Bonding
Authors: Lamanec Maximilián , Zienertová Jitka , Špeťko Matej , Nachtigallová Dana , Hobza Pavel 
Published: May 2024

AbstractAb initio calculations were employed to investigate the interactions between selected electron‐donating groups, characterized by M−H bonds (where M represents a transition metal and H denotes a hydridic hydrogen), and electron‐accepting groups featuring both σ‐ and π‐holes. The study utilized the ωB97X‐D3BJ/def2‐TZVPPD level of theory. Hydridic hydrogen complexes were found in all complexes with σ‐ and π‐holes. A comparative analysis was conducted on the properties hydridic H‐bond complexes, presented here and those studied previously, alongside an extended set of protonic H‐bonds complexes. While the stabilization energies changes in M−H bond lengths, vibrational frequencies, intensities of the spectral bands, and charge transfer for these complexes are comparable, the nature of hydridic and protonic H‐bonds fundamentally differ. In protonic H‐bond complexes, the main stabilization forces arise from electrostatic contributions, while in hydridic H‐bond complexes, dispersion energy, is the primary stabilization factor due to the excess of electrons and thus larger polarizability at hydridic H. The finding represents an important characteristic that distinguishes hydridic H‐bonding from protonic H‐bonds.
Psychotherapy on an Acute Psychiatric Ward: Preliminary Findings From a Controlled Study
Authors: Cohen‐Chazani Yael , Igra Libby , Hamm Jay A. , Leonhardt Bethany L. , Klion Reid , Cheli Simone , Hasson‐Ohayon Ilanit 
Published: May 2024

ABSTRACTThis study investigated the efficacy of psychotherapy during hospitalization on an acute psychiatric ward. A controlled trial was conducted to assess the effects of Metacognitive Reflection and Insight Therapy (MERIT) upon metacognition and psychiatric symptoms. Data from 40 inpatient women were analysed. Findings included significant interaction effects between group (intervention or control group) and time (preintervention and postintervention) in regard to the metacognitive abilities and general psychiatric symptoms. Participating in MERIT seems to improve one's ability to use reflective knowledge to cope with psychological challenges and to improve symptomatology level.
A fixed‐frequency second‐order generalized integrator phase‐locked loop‐based phase synchronization control in multisegment wireless power transfer systems
Authors: Wang Jintao , Shi Zhuoqun , Sun Qianfang , Guo Yanhua , Hou Yanjin , Liu Zhizhen 
Published: May 2024

SummaryMultisegment wireless power transfer (MSWPT) technology provides a solution to the challenges of dust‐free environments and automation faced by automated material handling systems (AMHS) in current semiconductor wafer factories. However, variations in track current frequency and phase offset on the transmitting side of the MSWPT technology may lead to significant deficits in energy transmission capability. This paper introduces a method based on the fixed‐frequency second‐order generalized integrator phase‐locked loop (FFSOGI‐PLL) structure for frequency and phase synchronization among multiple transmitters in a MSWPT system. By synchronizing the track currents of multiple transmitters, this method significantly enhances the energy harvesting capacity of the H‐type pickup in the overhead hoist transport (OHT) system, ensuring stable voltage at the receiver (Rx) load. Both theoretical simulations and experiments confirm that the proposed method can effectively capture the phase difference of track current and achieve frequency locking and phase tracking. Building on this theoretical foundation, we constructed three transmitter (Tx) systems and a 1.5 kW Rx equipped with an H‐type pickup. This setup is capable of real‐time monitoring and phase‐synchronization control of track currents with varying phase offsets. The results convincingly demonstrate the strong performance and stability of the proposed method.
Kinetic theory of weakly ionized plasma and electrolyte mixtures including Onsager matrix and frequency dispersion effects
Authors: Ebeling W. 
Published: May 2024

AbstractWe summarize the method of hydrodynamic approximation for weakly ionized plasmas developed with Klimontovich in 1962 and give a generalization to many—component systems using Onsagers matrix theory and including dispersion effects. We develop the conductivity theory of complex plasma and electrolyte mixtures based on the model of charged hard spheres with given non‐additive contact distances, including frequency‐dependent electric fields. These generalizations are made with the aim to allow applications to complex natural systems as atmospheric plasmas and seawater. Finally, we give as an example a numerical calculation of the single ion conductivities of a six‐component seawater model.
Multiband multiple‐input multiple‐output antenna design with high‐resolution circularly polarized wireless communication
Authors: Dhanalakshmi K. M. , Kavya G. 
Published: May 2024

SummaryA design problem of multiband multi‐input, multi‐output (MIMO) antenna arrays for maximal side lobe level lessening with constraint of a fixed beam width is dealt with. Multiband MIMO antenna is the most promising solution in a communication system, due to its maximal speed, higher data rate, and short‐range communication. Conversely, MIMO faces several complications including designing a proper antenna for a specific bandwidth and lesser antenna efficacy. In this manuscript, a high‐resolution CP multiband MIMO (HS‐CPMB‐MIMO) antenna design for wireless communication is proposed. MIMO antenna plays a vital part in the present wireless technology at MSA. A multiband microstrip line‐fed two‐port hybrid CPMIMO antenna is intended and fabricated. The proposed microstrip feed antenna contains a tapering structure, and the inverted L‐shaped slots in the radiating element are opened on both sides to present notches in sub‐6‐GHz frequencies. The inverted L‐shaped slots is positioned in the middle of asymmetric Z‐shaped radiating elements for enhancing the isolation among the two ports. The invention of a multiband MIMO antenna with four CP bands has an efficient ECC value because of a large L‐shaped slot in the ground as well as a protruding Z‐shape ground stub embedded with circular rings to have highly isolated cells. Finally, the proposed HS‐CPMB‐MIMO antenna design is implemented by utilizing simulation software CST Microwave Studio, and it is evaluated with the performance metrics. The simulation outcomes of the proposed HS‐CPMB‐MIMO antenna provide 36.34%, 57.36%, and 25.33% higher BW, 24.13%, 15.96%, and 21.22% higher gain compared with existing methods.
Invasive freshwater snails are less sensitive to population density than native conspecifics
Authors: Lewis Najev Briante Shevon , Neiman Maurine 
Published: May 2024

AbstractUnderstanding how and why some species or lineages become invasive is critically important for effectively predicting and mitigating biological invasions. Here, we address an important unanswered question in invasion biology: do key life‐history traits of invasive versus native lineages within a species differ in response to key environmental stressors? We focus on the environmental factor of population density, which is a fundamental characteristic of all populations, and investigate how changes in density affect native versus invasive Potamopyrgus antipodarum (New Zealand mudsnail). P. antipodarum has invaded 39 countries and detrimentally affects invaded environments. Previous studies of native and invasive populations and from laboratory experiments have demonstrated that growth and reproduction of P. antipodarum is sensitive to population density, though whether and how this sensitivity varies across native versus invasive lineages remains uncharacterized. We quantified individual growth rate and reproduction in P. antipodarum from multiple distinct native and invasive lineages across three different population density treatments. The growth of native but not invasive lineages decreased as density increased. There was no differential effect of density treatment on embryo production of invasive versus native snails, but a significantly higher proportion of snails were reproductive in high density compared to intermediate density for invasive lineages. In native lineages, there were no significant differences in the relative frequency of reproductive snails across density treatments. While the extent to which these results from our laboratory study can be extrapolated to the more complex natural world remain unclear, our findings are consistent with a scenario where differential sensitivity to population density could help explain why some lineages become successful invaders. Our findings also align with previous studies that show that invasive P. antipodarum lineages exhibit a relatively wide range of tolerance to environmental stressors.
Updated range map of an endangered salamander and congeneric competitor reveals different niche preferences
Authors: Werba Jo A. , Miller David A. W. , Brand Adrianne B. , Grant Evan H. Campbell 
Published: May 2024

AbstractEstimating distributions for cryptic and highly range‐restricted species induces unique challenges for species distribution modeling. In particular, bioclimatic covariates that are typically used to model species ranges at regional and continental scales may not show strong variation at scales of 100s and 10s of meters. This limits both the likelihood and usefulness of correlated occurrence to data typically used in distribution models. Here, we present analyses of species distributions, at 100 × 100 m resolution, for a highly range restricted salamander species (Shenandoah salamander, Plethodon shenandoah) and a closely related congener (red‐backed salamander, Plethodon cinereus). We combined data across multiple survey types, account for seasonal variation in availability of our target species, and control for repeated surveys at locations– all typical challenges in range‐scale monitoring datasets. We fit distribution models using generalized additive models that account for spatial covariates as well as unexplained spatial variation and spatial uncertainty. Our model accommodates different survey protocols using offsets and incorporates temporal variation in detection and availability resulting from survey‐specific variation in temperature and precipitation. Our spatial random effect was crucial in identifying small‐scale differences in the occurrence of each species and provides cell‐specific estimates of uncertainty in the density of salamanders across the range. Counts of both species were seen to increase in the 3 days following a precipitation event. However, P. cinereus were observed even in extremely wet conditions, while surface activity of P. shenandoah was associated with a more narrow range. Our results demonstrate how a flexible analytical approach improves estimates of both distribution and uncertainty, and identify key abiotic relationships, even at small spatial scales and when scales of empirical data are mismatched. While our approach is especially valuable for species with small ranges, controlling for spatial autocorrelation, estimating spatial uncertainty, and incorporating survey‐specific information in estimates can improve the reliability of distribution models in general.
Heterogeneity in breeding productivity is driven largely by factors affecting nestlings and young fledglings in an imperiled migratory passerine
Authors: McNeil Darin J. , Rodewald Amanda D. , Ruiz‐Gutierrez Viviana , Fiss Cameron J. , Larkin Jeffery L. 
Published: May 2024

AbstractIdentifying factors that drive variation in vital rates among populations is a prerequisite to understanding a species' population biology and, ultimately, to developing effective conservation strategies. This is especially true for imperiled species like the golden‐winged warbler (Vermivora chrysoptera) that exhibit strong spatial heterogeneity in demography and responds variably to conservation interventions. Habitat management actions recommended for breeding grounds conservation include timber harvest, shrub shearing, and prescribed fire that maintain or create early successional woody communities. Herein, we assessed variation in the survival of nests [n = 145] and fledglings [n = 134] at 17 regenerating timber harvest sites within two isolated populations in Pennsylvania that differed in productivity and response to habitat management. Although the overall survival of nests and fledglings was higher in the eastern population than the central population, this was only true when the nest phases and fledgling phases were considered wholly. Indeed, survival rates of nestlings and recently fledged young (1–5 days post‐fledging) were lower in the central population, whereas eggs and older fledglings (6–30 days post‐fledging) survived at comparable rates in both populations. Fledglings in the central population were smaller (10% lower weight) and begged twice as much as those in the eastern population, suggesting food limitation may contribute to lower survival rates. Fledgling survival in the central population, but not the eastern, also was a function of habitat features (understory vegetation density [positive] and distance to mature forest [negative]) and individual factors (begging effort [negative]). Our findings illustrate how identifying how survival varies across specific life stages can elucidate potential underlying demographic drivers, such as food resources in this case. In this way, our work underscores the importance of studying and decomposing stage‐specific demography in species of conservation concern.
Super‐liquid‐repellent thin film materials for low temperature latent heat thermal energy storage: A comprehensive review of materials for dip‐coating
Authors: Muhumuza Ronald , Eames Philip C. 
Published: May 2024

AbstractWhen discharging latent heat thermal energy storage (LHTES) systems, performance is influenced by the formation and adherence of a solid layer of phase change material (PCM) on heat eXchange (HX) surfaces. Super‐liquid‐repellent thin films (STFs) may be able to reduce solidifying PCM adhesion on HX surfaces during discharging, delay PCM solidification to lower temperatures, and by modifying nucleation sites potentially enable long‐term seasonal thermal storage. Techniques employed previously to fabricate sintered polymeric STF coatings include chemical vapour deposition, dip‐coating, spray‐coating, spin‐coating, layer‐by‐layer (LbL) assembly, sol‐gel, anodizing, electrodeposition, electrospinning, so on. Dip‐coating is considered attractive for fabricating thin films on simple and complex surface geometries due to process maturity, scalability, flexibility and cost‐effectiveness. To identify suitable materials for preparing STFs on metal HX surfaces using the dip‐coating process, more than 200 journal articles published in English during the period 2010 to 2022 were reviewed and the potential role of STFs in LHTES applications was assessed. The review identified key areas and applications stimulating STF material developments and formulations. The dip‐coating of potential STF materials was classified under three major themes driving current research and development (R&D) activities, that is, high performance thin films, eco‐friendly thin films and fundamental research formulations. This review provides a platform from which to develop coatings and HX systems to enable the cost‐effective implementation of STFs for improved heat transfer in future mobile/stationery LHTES systems.