bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three nonconventional starch: Comparison of physicochemical properties and in vitro digestibility
Authors: Wu Xiuli , Wang Mengyang , Liu Rui , Miao Xinzhu , Liu Jinliang 
Published: June 2024

AbstractExtraction of starch from waste is also an effective way to recover resources and provide new sources of starch. In this study, starch was isolated from white kidney bean residue, chickpea residue, and tiger nut meal after protein or oil extraction, and the morphology of starch particles was observed to determine their physicochemical properties and in vitro digestibility. All these isolated starches had unique properties, among which white kidney bean starch (KBS) had a high amylose content (43.48%), and its structure was better ordered. Scanning electron microscopy revealed distinct granular morphologies for the three starches. KBS and chickpea starch (CHS) were medium‐granular starches, whereas tiger nut starch was a small granular starch. Fourier transform infrared spectroscopy analysis confirmed the absence of significant differences in functional groups and chemical bonds among the three starch molecules. In vitro digestibility studies showed that CHS is more resistant to enzymatic degradation. Overall, these results will facilitate the development of products based on the separation of nonconventional starches from waste.
Clinical validation of the ineffective social support network nursing diagnosis in violence‐victimized women
Authors: Farias Camila EL , Mendes Ryanne CMG , Lopes Marcos VO , França Michelline S , Perrelli Jaqueline GA , Pontes Cleide M , Mangueira Suzana O 
Published: June 2024

AbstractPurposeTo verify clinical validity evidence for the ineffective social support network nursing diagnosis.MethodA quantitative, descriptive, cross‐sectional study was performed with 98 violence‐victimized women treated in two reference centers for violence in the city of Recife, Pernambuco, Brazil. The women were interviewed from August 2021 to June 2022.FindingsThe clinical indicators that best predicted the nursing diagnosis were as follows: Frustration with unmet support expectations, negative social interaction, perceived neglect of support demands, feeling of abandonment, low reciprocity, and encouragement of negative behaviors. Etiological factors that showed greater association were excessive demand for support, limited social network, social isolation, the fragility of institutional service networked organizations, and inadequate appreciation of available social support.ConclusionsThe clinical validity evidence for the ineffective social support network nursing diagnosis has been verified. Thus, the validated clinical indicators and etiological factors can accurately diagnose and predict the emergence of this phenomenon in violence‐victimized women.Implications for nursing practiceThe results contribute to advancing scientific knowledge in nursing teaching, research, and practice and support the nursing process in violence‐victimized women.
Global availability and uptake of psychological services for adults, caregivers and children with food allergy
Authors: Knibb R. C. , Herbert L. J. , Jones C. J. , Protudjer J. L. P. , Screti C. , Roleston C. , Brough H. A. , Warren C. , Lombard L. , Santos A. F. , Gupta R. , Vickery B. P. , Marchisotto M. J. 
Published: June 2024

AbstractBackgroundFood allergy (FA) is associated with poor health‐related quality of life and high levels of psychological distress. Psychological support is extremely important but not always available. As part of the Global Access to Psychological Services for Food Allergy (GAPS) study, we aimed to assess psychological distress and service use among adults, caregivers and children with FA in a global survey.MethodsParticipants (n = 1329 adults with FA; n = 1907 caregivers of children with FA) from >20 countries were recruited through patient organisations, social media advertisements and online survey panels to complete an online survey. Surveys were available in six languages.ResultsA total of 67.7% of adults and 77.2% of caregivers reported direct experience, and 51.6% of caregivers said their child had experienced FA‐related psychological distress. The most commonly reported issue was anxiety about having an allergic reaction. Less than 20% had been assessed for FA‐related psychological distress. There were significant differences across countries for levels of distress, screening for distress, seeing a mental health professional and being diagnosed with a FA‐related mental health disorder (all p < .001). The United Kingdom, Australia and Brazil had the highest number of participants reporting distress. The most commonly reported barrier to seeing a mental health professional was cost.ConclusionsFA‐related distress is common across countries, but with substantial country‐to‐country variability. Allergy providers are encouraged to routinely assess families for psychological distress and provide access to appropriate mental health resources. Development and implementation of evidence‐based, patient‐informed accessible, affordable FA interventions in multiple languages is urgently needed.
Economic impacts of the EU–China comprehensive investment agreement: A dynamic general equilibrium analysis
Authors: Zhai Fan , Zhuang Juzhong 
Published: June 2024

AbstractUsing a global dynamic general equilibrium model with foreign direct investment (FDI) and technology capital, this paper finds that the EU–China Comprehensive Agreement on Investment (CAI) could bring modest but nonnegligible benefits to both sides. Under an illustrative scenario in which the CAI increases the degree of openness to bilateral FDI by 10%, the EU's FDI to China could rise by a factor of 3–4 and China's FDI to the EU by a factor of 3. These would generate a gain in the steady‐state gross national product (GNP) of 0.23% for China and 0.73% for the EU. The cumulative household welfare gain in the present value term is equivalent to 0.36% and 0.13% of GNP annually for China and the EU, respectively.
One out of two idiopathic infertile men has pathologic sperm DNA fragmentation values: Potential implications for clinical practice
Authors: Boeri Luca , Pozzi Edoardo , Belladelli Federico , Corsini Christian , Cilio Simone , Bertini Alessandro , Lanzaro Francesco , Candela Luigi , Raffo Massimiliano , Negri Fausto , Cella Ludovica , Fantin Margherita , Fallara Giuseppe , Capogrosso Paolo , d'Arma Alessia , Montorsi Francesco , Salonia Andrea 
Published: June 2024

AbstractObjectivesTo investigate the distribution of sperm DNA fragmentation (SDF) values and their association with clinical and seminal parameters in idiopathic infertile men.Design, Patients, MeasurementsData from 3224 primary infertile men (belonging to couples having failed to conceive a pregnancy within 12 months) who underwent a thorough diagnostic work‐up were analysed. A SDF value ≥ 30% (according to Sperm Chromatin Structure Assay) was considered pathologic. We excluded: (1) men with genetic abnormalities; (2) men with history of cryptorchidism; (3) men with biochemical hypogonadism; (4) men with clinical varicocele; and (5) men with other possible known aetiological factors. Descriptive statistics and logistic regression analyses were used to describe the whole cohort.ResultsOf all, 792 (23%) men with at least one abnormal WHO semen parameter but without any identified aetiologic factor for infertility, were considered as idiopathic infertile men. Of 792, 418 (52.7%) men had SDF ≥30%. Men with pathologic SDF were older (p = .02), had higher Follicle‐stimulating hormone (FSH) (p = .04) but lower total testosterone (p = .03) values than those with SDF <30%. The homoeostatic model assessment index for insulin resistance (HOMA‐IR) was higher in men with SDF ≥30% (p = .01). Idiopathic infertile men with SDF ≥30% presented with lower sperm concentration (p < .001) and lower progressive sperm motility (p < .01) than those with SDF < 30%. Logistic regression analysis revealed that older age (OR: 1.1, p = .02) and higher HOMA‐IR score (OR: 1.8, p = .03) were associated with SDF ≥ 30%, after accounting for FSH and sperm concentration values.ConclusionsApproximately half of infertile men categorized as idiopathic had pathologic SDF values. Idiopathic infertile men with pathologic SDF showed worse clinical, hormonal and semen parameters than those with normal SDF values. These results suggest that including SDF testing could be clinically relevant over the real‐life management work‐up of infertile men.
Society for endocrinology guideline for understanding, diagnosing and treating female hypogonadism
Authors: Jayasena Channa N. , Devine Kerri , Barber Katie , Comninos Alexander N. , Conway Gerard S. , Crown Anna , Davies Melanie C. , Ewart Ann , Seal Leighton J. , Smyth Arlene , Turner Helen E. , Webber Lisa , Anderson Richard A. , Quinton Richard 
Published: June 2024

AbstractFemale hypogonadism (FH) is a relatively common endocrine disorder in women of premenopausal age, but there are significant uncertainties and wide variation in its management. Most current guidelines are monospecialty and only address premature ovarian insufficiency (POI); some allude to management in very brief and general terms, and most rely upon the extrapolation of evidence from the studies relating to physiological estrogen deficiency in postmenopausal women. The Society for Endocrinology commissioned new guidance to provide all care providers with a multidisciplinary perspective on managing patients with all forms of FH. It has been compiled using expertise from Endocrinology, Primary Care, Gynaecology and Reproductive Health practices, with contributions from expert patients and a patient support group, to help clinicians best manage FH resulting from both POI and hypothalamo‐pituitary disorders, whether organic or functional.
Histomorphometric and microtomographic analysis of maxillary sinus augmentation surgeries with and without collagen membrane on the lateral window: A randomized clinical trial
Authors: Souza Ramiro Beato , Alves Haimon Diniz Lopes , Oliveira Luciano Santos , Pires Fabio Ramoa , Vidigal Guaracilei Maciel , Fischer Ricardo Guimaraes 
Published: June 2024

AbstractObjectiveTo evaluate the histomorphometric and computerized microtomographic (Micro‐CT) analysis of the regenerated bone tissue from maxillary sinus augmentation surgery, with and without using the collagen membrane on the external osteotomy window.Materials and MethodsTwelve patients were selected for this prospective, controlled, and randomized study. The patients were submitted to bilateral maxillary sinus surgery in a split‐mouth design. On the test side, the maxillary sinus augmentation procedure included using Geistlich Bio‐Oss® and a Geistlich Bio‐Gide® collagen membrane covering the lateral osteotomy window. On the control side, only Geistlich Bio‐Oss® was used without the presence of the membrane. After 6 months, the surgeries for implant installation were performed. In this surgical phase, specimens of the regenerated tissue were collected for histological and Micro‐CT analysis.ResultsIn the histomorphometric evaluation, the mean (±SD) percentages of newly formed bone were 43.9% (±11.5) and 40.8% (±8.9) in the test and control groups, respectively. The corresponding values of the Micro‐CT analysis were 36.6% (±3.4) and 37.2% (±4.7) in the test and control groups, respectively. There was no statistically significant difference between the test and control groups in the two methods. In addition, there was no statistically significant difference between the mean percentage of biomaterial remaining between the test and control groups. However, the mean percentage of newly formed bone was significantly higher and the mean percentage of remaining biomaterial was significantly lower in the histomorphometric analysis compared to the values obtained through microtomography.ConclusionThe additional use of collagen membranes in maxillary sinus surgery does not offer advantages in newly formed bone.
Early reverse remodeling by echocardiography after transcatheter aortic valve implantation
Authors: Skulstad Helge , Andresen K. , Aaberge Lars , Haugaa Kristina H. , Edvardsen Thor , Kaya Esra 
Published: June 2024

AbstractIntroductionOslo University Hospital is a tertiary center conducting a significant number of transcatheter aortic valve implantation (TAVI) procedures per year. In this follow‐up MediPace study, we aimed to investigate early echocardiographic changes in systolic and diastolic functions after TAVI in these patients.MethodsAll patients enrolled in the previous study were contacted 3 months after TAVI for echocardiographic evaluation. Detailed echocardiography was performed 3.5 ± 1.6 months after TAVI, and compared with baseline evaluations.ResultsA total of 101 patients were analyzed. Mean age was 80.1 ± 6.8 years and 40% of the patients were female. We observed a significant improvement in global longitudinal strain (GLS) (pre‐TAVI −16.8 ± 4.1%, post‐TAVI −17.8 ± 3.6%, p < .001), with no notable change in LVEF. More than half of the patients (52%) experienced a significant reverse remodeling with ≥10% decrease in left ventricular mass index (LVMi) following TAVI (pre‐TAVI 123.6 ± 32.1 vs. 109.7 ± 28.9 g/m2 post‐TAVI, p < .001). Pre‐TAVI LVMi was a positive predictor, whereas history of HT was a negative predictor of LVMi reduction. There was no significant improvement in diastolic function following TAVI. Highest degree of paravalvular leakage was mild to moderate and was observed in only 2%.ConclusionsA significant improvement in GLS and LVMi was found following TAVI. History of hypertension and baseline LVMi were predictors of LVMi change. There was no notable change in diastolic function, including left atrial strain.
Insights into Notonecta maculata biology and its consumptive and non‐consumptive effects on Aedes albopictus
Authors: Farina Priscilla , Bedini Stefano , Abenaim Linda , Conti Barbara 
Published: June 2024

AbstractNotonecta species (Hemiptera: Notonectidae) are generalist true predators with a strong impact on the size, structure, and richness of the aquatic communities, particularly on mosquito populations. Juvenile and adult backswimmers not only prey on mosquito larvae (consumptive effect) but their presence can also deter the oviposition of gravid mosquito females (non‐consumptive effect). In this study, we selected a Western Palearctic backswimmer, Notonecta maculata Fabricius, as a predator and deterrent of the highly invasive and health‐threatening Asian tiger mosquito, Aedes albopictus (Skuse) (Diptera: Culicidae). In central Italy, N. maculata is univoltine and overwinters in the adult stage. Females lay eggs from February to the end of May, and the first new adults will emerge in late June; the complete nymphal development requires 44.5 ± 3.1 days. The number of Ae. albopictus larvae preyed on by N. maculata during its growth increases while developing, going from 0.03 ± 0.02 larvae per day for first instar nymphs to 21.38 ± 2.90 for mature adults. Furthermore, the presence of a single N. maculata adult in a mosquito ovitrap is enough to discourage the Ae. albopictus oviposition for up to 5 days. Limiting mosquito populations and, consequently, the transmission of viruses and parasites should be our main goal. Therefore, the integrated management of Ae. albopictus by the use of insecticides and a predator (such as backswimmer juveniles and adults), even if only in specific situations, may be promising and feasible. A more in‐depth knowledge of the biological cycle of N. maculata could help, consequently, to optimize its mass rearing.
Comprehensive scoping review of fenfluramine's role in managing generalized tonic–clonic seizures in developmental and epileptic encephalopathies
Authors: Gil‐Nagel Antonio , Cross J. Helen , Devinsky Orrin , Ceulemans Berten , Lagae Lieven , Knupp Kelly , Schoonjans An‐Sofie , Ryvlin Philippe , Thiele Elizabeth A. , Polega Shikha , Lothe Amélie , Nabbout Rima 
Published: June 2024

AbstractDevelopmental and epileptic encephalopathies (DEEs) are characterized by pharmacoresistant seizures and developmental delay. Patients with DEEs experience multiple seizure types, including tonic–clonic seizures (TCS) that can be generalized tonic–clonic (GTCS) or focal evolving to bilateral tonic–clonic (FBTCS). Fenfluramine (FFA) has demonstrated efficacy in reduction of TCS in patients with Dravet syndrome (DS), Lennox–Gastaut syndrome (LGS), and other DEEs. Using the PRISMA‐ScR (Preferred Reporting Items for Systematic Review and Meta‐Analyses extension for Scoping Review) guidelines, we performed a scoping review to describe changes in TCS in patients treated with FFA. A comprehensive search of five literature databases was conducted up to February 14, 2023. Studies were included if they reported change in GTCS or TCS (but not FBTCS) after treatment with FFA in patients with DEEs. Duplicate patients and studies with unclear efficacy data were excluded. Fourteen of 422 studies met the eligibility criteria. Data extracted and evaluated by expert clinicians identified 421 unique patients with DS (in nine studies), CDKL5 deficiency disorder, SCN8A‐related disorder, LGS, SCN1B‐related disorder, and other DEEs. The median percent reduction in GTCS or TCS from baseline was available in 10 studies (n = 328) and ranged from 47.2% to 100%. Following FFA treatment, 10 studies (n = 144) reported ≥50% reduction in GTCS or TCS from baseline in 72% of patients; in nine of those (n = 112), 54% and 29% of patients achieved ≥75% and 100% reduction in GTCS or TCS from baseline, respectively. Overall, this analysis highlighted improvements in GTCS or TCS frequency when patients were treated with FFA regardless of the DEE evaluated. Future studies may confirm the impact of FFA on TCS reduction and on decreased premature mortality risk (including sudden unexpected death in epilepsy), improvement in comorbidities and everyday executive function, decreased health care costs, and improvement in quality of life.
Long‐term soil warming decreases soil microbial necromass carbon by adversely affecting its production and decomposition
Authors: Liu Xiaofei , Tian Ye , Heinzle Jakob , Salas Erika , Kwatcho‐Kengdo Steve , Borken Werner , Schindlbacher Andreas , Wanek Wolfgang 
Published: June 2024

AbstractMicrobial necromass carbon (MNC) accounts for a large fraction of soil organic carbon (SOC) in terrestrial ecosystems. Yet our understanding of the fate of this large carbon pool under long‐term warming is uncertain. Here, we show that 14 years of soil warming (+4°C) in a temperate forest resulted in a reduction in MNC by 11% (0–10 cm) and 33% (10–20 cm). Warming caused a decrease in the content of MNC due to a decline in microbial biomass carbon and reduced microbial carbon use efficiency. This reduction was primarily caused by warming‐induced limitations in available soil phosphorus, which, in turn, constrained the production of microbial biomass. Conversely, warming increased the activity of soil extracellular enzymes, specifically N‐acetylglucosaminidase and leucine aminopeptidase, which accelerated the decomposition of MNC. These findings collectively demonstrate that decoupling of MNC formation and decomposition underlie the observed MNC loss under climate warming, which could affect SOC content in temperate forest ecosystems more widespread.
Risk factors predicting subtypes of physical frailty incidence stratified by musculoskeletal diseases in community‐dwelling older adults: The SONIC study
Authors: Ohata Yuka , Godai Kayo , Kabayama Mai , Kido Michiko , Akagi Yuya , Tseng Winston , Maus Marlon , Akasaka Hiroshi , Takami Yoichi , Yamamoto Koichi , Gondo Yasuyuki , Yasumoto Saori , Ogawa Madoka , Kasuga Ayaka , Matsumoto Kiyoaki , Masui Yukie , Ikebe Kazunori , Arai Yasumichi , Ishizaki Tatsuro , Kamide Kei 
Published: June 2024

AimThis study aims to identify the key risk factors that lead to subtypes of physical frailty assessed by walking speed and grip strength among community‐dwelling Japanese individuals, stratified by the presence of musculoskeletal diseases (MSDs) and age group.MethodsWe included 302 participants aged 70 or 80 years who did not exhibit subtypes of physical frailty at baseline through the Septuagenarians, Octogenarians, Nonagenarians, Investigation with Centenarians (SONIC) study. Our study was a longitudinal study. The outcome was the incidence of subtypes of physical frailty after 3 years. Subtypes of physical frailty were defined as a weak grip strength or slow walking speed, or both, based on the Japanese version of the Cardiovascular Health Study Index. The risk factors for subtypes of physical frailty incidence were examined by age group and MSD, using multivariate logistic regressions.ResultsOf the 302 participants, 110 (36.4%) had MSD. Those with MSD were significantly more likely to have subtypes of physical frailty after 3 years compared with those without MSD. Among all participants, older age was a risk factor of subtypes of physical frailty (P < 0.05). Without MSD, older age and dissatisfied financial status were risk factors (P < 0.05). With MSD, older age was a risk factor (P < 0.05). By age group, in individuals aged 70 years old, a dissatisfied financial status was a risk factor for those without MSD (P < 0.05), and a higher BMI was one for those with MSD (P < 0.05).ConclusionsOlder age was a risk factor for subtypes of physical frailty, but other risk factors differed according to the presence of MSD and age. Geriatr Gerontol Int 2024; 24: 797–805.
Ki‐67 distribution, α‐methylacyl‐CoA racemase (AMACR) expression and mucin phenotypes are associated with non‐polypoid growth in ulcerative colitis‐associated neoplasia
Authors: Okano Soh , Fukata Masayuki , Murakami Takashi , Nojiri Shuko , Kodama Makoto , Abe Keiko , Yamana Tetsuo , Saito Tsuyoshi , Yao Takashi 
Published: June 2024

AimsUlcerative colitis‐associated neoplasia (UCAN) is characterised by multifocal tumourigenesis. A wide range of metachronous lesions have been reported to occur after endoscopic treatment of UCAN, which suggests the development of sporadic tumours in lesions treated as UCAN. Therefore, we aimed to evaluate differences of immunohistochemistry (IHC) in features and clinicopathological characteristics of intramucosal lesions in patients with ulcerative colitis (UC).Methods and resultsWe examined 35 intramucosal lesions resected for carcinoma or dysplasia by total colectomy from patients with UC and 71 sporadic adenomas (SAs) endoscopically resected from patients without UC. UC lesions were divided into the conventional UCAN group, defined as p53 mutant pattern and normal expression of β‐catenin, and the non‐conventional UCAN group, defined as the rest. Ki‐67 distribution, α‐methylacyl‐CoA racemase (AMACR) expression and mucin phenotypes were compared using IHC, and clinicopathological characteristics were investigated. Conventional and non‐conventional UCAN lesions were located in the left colon and rectum. Relative to the SA lesions, UCAN lesions occurred in much younger patients and exhibited more frequent basal distribution of Ki‐67 in tumour crypts. Conventional UCAN lesions tended to be non‐polyploid and exhibited a higher frequency of normal AMACR expression than SA lesions. UC lesions were heterogeneous—only two of the eight patients with multiple lesions had lesions (both non‐conventional UCAN lesions) exhibiting concordant IHC staining features.ConclusionsThe basal pattern of Ki‐67 distribution, normal expression of AMACR and a non‐intestinal mucin phenotype were determined as characteristic features suggestive of UCAN. Non‐polypoid growth was another a key feature of UCAN.