bluuebunny/crossref_metadata_2025_split huggingface dataset:
Planetary cratering 1. The question of multiple impactor populations: Lunar evidence
Authors: Hartmann William K. 
Published: June 2012

Abstract— This paper addresses several current issues related to use of craters in interpreting planetary surface histories. The primary goal is to test the widely adopted hypothesis of multiple populations of impactors at different times or places in the Solar System.New data presented here revise a “lunar highland” crater diameter distribution that has been widely used as evidence of an early distinct population of impactors. This curve, which has a depression of the size distribution at mid‐sizes, does not, in fact, represent the lunar highlands generally. I show that it is associated with regions of intercrater plains. The more extensive the obliteration by intercrater plains, the deeper the depression. Modeling indicates that the depression of the curve is caused by the obliteration process itself. The oldest, most cratered regions of lunar highlands do not show the depression.These findings call into question earlier interpretations of multiple populations of impactors in the Solar System and of a distinctive primordial population.The present work is consistent, instead, with (1) a relatively uniform size distribution of interplanetary impactors, of mixed origins, back to 4 Ga ago and throughout the sampled Solar System; (2) fragmentation as the process that produced that size distribution; (3) saturation equilibrium on the most heavily cratered surfaces; and (4) differences in structure in the size distribution caused not by distinct impactor populations but by episodes of endogenic obliteration.If accepted, these results would modify some studies of solar system evolution, including assertions of two to five distinct populations of impactors, assumptions of lack of saturation equilibrium, and identifications of specific heliocentric or planetocentric sources for impactors within outer planet satellite systems.
Mineralogy of a refractory inclusion in the Allende (C3V) meteorite
Authors: Steele Ian M. 
Published: June 2012

Abstract— A spherical, 220‐μm diameter, spinel‐hibonite‐perovskite inclusion from the Allende C3V meteorite contains a central hibonite cluster with an angular boundary. This central hibonite is enclosed within spinel that is zoned from Mg‐rich at the hibonite boundary to more Fe‐rich at the inclusion boundary. This spinel zone includes lath‐shaped hibonites usually oriented subradial to the central hibonites. Two textural types of perovskites are present as exsolution from the central hibonite and as equidimensional grains within both the central hibonite and spinel. These second perovskites have exsolution lamellae of Al2O3. Within the central hibonite and adjacent to some equidimensional perovskites, a fine porous phase interpreted as alteration has a composition of nearly pure Al2O3 with minor amounts of Na and Si. This is possibly either an intergrowth of corundum and nepheline or a modified Al2O3, β‐alumina.The central hibonites and equidimensional perovskites are considered relict grains on which the spinel‐hibonite layer crystallized. The relict material had undergone slow cooling in a previous event to produce exsolution of original high‐temperature compositions. Later alteration caused breakdown of hibonite to give an Al2O3‐rich phase. This inclusion represents a composite body which formed in a Ca‐Al‐rich environment.
Coolidge and Loongana 001: A new carbonaceous chondrite grouplet
Authors: Kallemeyn Gregory W. , Rubin Alan E. 
Published: June 2012

Abstract— Petrographic and bulk compositional data suggest the existence of a new grouplet of carbonaceous chondrites consisting of Coolidge and Loongana 001. Coolidge is a carbonaceous chondrite find from Kansas, USA, previously considered a metamorphosed CV chondrite. Loongana 001 is a recent find from Western Australia. It has a high matrix/chondrule modal abundance ratio, 1–2 vol% refractory inclusions and high refractory lithophile abundance ratios (∼1.35x CI), indicating that it is a carbonaceous chondrite.Coolidge and Loongana 001 have many compositional and petrographic similarities. They have refractory element abundances in the range of CV chondrites, significantly higher than those in the CR chondrites. They have similar volatile element abundance patterns showing low volatile element abundances relative to both CR and CV chondrites. Coolidge and Loongana 001 have similar chondrule dimensions and shapes, oxidation states and opaque mineral assemblages. They are also similar in petrologic type (3.8–4) and shock stage (S2).Although both Coolidge and Loongana 001 may be related to the CV clan, they are not CV chondrites, nor are they formed by metamorphism of a CV precursor. They are distinctly different in composition from CV chondrites and their chondrules are smaller and have a much lower abundance of coarse‐grained chondrule rims. Coolidge and Loongana 001 constitute a distinct carbonaceous chondrite grouplet.
Factors influencing response to Botulinum toxin type A in patients with idiopathic cervical dystonia: results from an international observational study
Authors: Misra Vijay P , Ehler Edvard , Zakine Benjamin , Maisonobe Pascal , Simonetta-Moreau Marion ,   on behalf of the INTEREST IN CD group
Published: June 2012

ObjectivesReal-life data on response to Botulinum toxin A (BoNT-A) in cervical dystonia (CD) are sparse. An expert group of neurologists was convened with the overall aim of developing a definition of treatment response, which could be applied in a non-interventional study of BoNT-A-treated subjects with CD.DesignInternational, multicentre, prospective, observational study of a single injection cycle of BoNT-A as part of normal clinical practice.Setting38 centres across Australia, Belgium, Czech Republic, France, Germany, The Netherlands, Portugal, Russia and the UK.Participants404 adult subjects with idiopathic CD. Most subjects were women, aged 41–60 years and had previously received BoNT-A.Outcome measuresPatients were classified as responders if they met all the following four criteria: magnitude of effect (≥25% improvement Toronto Western Spasmodic Torticollis Rating Scale), duration of effect (≥12-week interval between the BoNT-A injection day and subject-reported waning of treatment effect), tolerability (absence of severe related adverse event) and subject's positive Clinical Global Improvement (CGI).ResultsHigh rates of response were observed for magnitude of effect (73.6%), tolerability (97.5%) and subject's clinical global improvement (69.8%). The subjective duration of effect criterion was achieved by 49.3% of subjects; 28.6% of subjects achieved the responder definition. Factors most strongly associated with response were age (<40 years; OR 3.9, p<0.05) and absence of baseline head tremor (OR 1.5; not significant).ConclusionsThree of four criteria were met by most patients. The proposed multidimensional definition of response appears to be practical for routine practice. Unrealistically high patient expectation and subjectivity may influence the perception of a quick waning of effect, but highlights that this aspect may be a hurdle to response in some patients.Clinical registration number(NCT00833196;ClinicalTrials.gov).
Probabilistic modeling for job symbiosis scheduling on SMT processors
Authors: Eyerman Stijn , Eeckhout Lieven 
Published: June 2012

Symbiotic job scheduling improves simultaneous multithreading (SMT) processor performance by coscheduling jobs that have “compatible” demands on the processor's shared resources. Existing approaches however require a sampling phase, evaluate a limited number of possible coschedules, use heuristics to gauge symbiosis, are rigid in their optimization target, and do not preserve system-level priorities/shares.
This article proposes probabilistic job symbiosis modeling, which predicts whether jobs will create positive or negative symbiosis when coscheduled without requiring the coschedule to be evaluated. The model, which uses per-thread cycle stacks computed through a previously proposed cycle accounting architecture, is simple enough to be used in system software. Probabilistic job symbiosis modeling provides six key innovations over prior work in symbiotic job scheduling: (i) it does not require a sampling phase, (ii) it readjusts the job coschedule continuously, (iii) it evaluates a large number of possible coschedules at very low overhead, (iv) it is not driven by heuristics, (v) it can optimize a performance target of interest (e.g., system throughput or job turnaround time), and (vi) it preserves system-level priorities/shares. These innovations make symbiotic job scheduling both practical and effective.
Our experimental evaluation, which assumes a realistic scenario in which jobs come and go, reports an average 16% (and up to 35%) reduction in job turnaround time compared to the previously proposed SOS (sample, optimize, symbios) approach for a two-thread SMT processor, and an average 19% (and up to 45%) reduction in job turnaround time for a four-thread SMT processor.
Benefits of selective packet discard in networks-on-chip
Authors: Lankes Andreas , Wild Thomas , Wallentowitz Stefan , Herkersdorf Andreas 
Published: June 2012

Today, Network on Chip concepts principally assume inherent lossless operation. Considering that future nanometer CMOS technologies will witness increased sensitivity to all forms of manufacturing and environmental variations (e.g., IR drop, soft errors due to radiation, transient temperature induced timing problems, device aging), efforts to cope with data corruption or packet loss will be unavoidable. Possible counter measures against packet loss are the extension of flits with ECC or the introduction of error detection with retransmission.
We propose to make use of the perceived deficiency of packet loss as a feature. By selectively discarding stuck packets in the NoC, a proven practice in computer networks, all types of deadlocks can be resolved. This is especially advantageous for solving the problem of message-dependent deadlocks, which otherwise leads to high costs either in terms of throughput or chip area. Strict ordering, the most popular approach to this problem, results in a significant buffer overhead and a more complex router architecture. In addition, we will show that eliminating local network congestions by selectively discarding individual packets also can improve the effective throughput of the network. The end-to-end retransmission mechanism required for the reliable communication, then also provides lossless communication for the cores.
Targeting the Insulin Growth Factor and the Vascular Endothelial Growth Factor Pathways in Ovarian Cancer
Authors: Shao Minghai , Hollar Stacy , Chambliss Daphne , Schmitt Jordan , Emerson Robert , Chelladurai Bhadrani , Perkins Susan , Ivan Mircea , Matei Daniela 
Published: June 2012

Abstract
Antiangiogenic therapy is emerging as a highly promising strategy for the treatment of ovarian cancer, but the clinical benefits are usually transitory. The purpose of this study was to identify and target alternative angiogenic pathways that are upregulated in ovarian xenografts during treatment with bevacizumab. For this, angiogenesis-focused gene expression arrays were used to measure gene expression levels in SKOV3 and A2780 serous ovarian xenografts treated with bevacizumab or control. Reverse transcription-PCR was used for results validation. The insulin growth factor 1 (IGF-1) was found upregulated in tumor and stromal cells in the two ovarian xenograft models treated with bevacizumab. Cixutumumab was used to block IGF-1 signaling in vivo. Dual anti-VEGF and IGF blockade with bevacizumab and cixutumumab resulted in increased inhibition of tumor growth. Immunohistochemistry measured multivessel density, Akt activation, and cell proliferation, whereas terminal deoxynucleotidyl transferase–mediated dUTP nick end labeling (TUNEL) assay measured apoptosis in ovarian cancer xenografts. Bevacizumab and cixutumumab combination increased tumor cell apoptosis in vivo compared with therapy targeting either individual pathway. The combination blocked angiogenesis and cell proliferation but not more significantly than each antibody alone. In summary, IGF-1 activation represents an important mechanism of adaptive escape during anti-VEGF therapy in ovarian cancer. This study provides the rationale for designing bevacizumab-based combination regimens to enhance antitumor activity. Mol Cancer Ther; 11(7); 1576–86. ©2012 AACR.
Periprocedural Bleeding and Thromboembolic Events With Dabigatran Compared With Warfarin
Authors: Healey Jeff S. , Eikelboom John , Douketis James , Wallentin Lars , Oldgren Jonas , Yang Sean , Themeles Ellison , Heidbuchel Hein , Avezum Alvaro , Reilly Paul , Connolly Stuart J. , Yusuf Salim , Ezekowitz Michael 
Published: June 2012

Background—
Dabigatran reduces ischemic stroke in comparison with warfarin; however, given the lack of antidote, there is concern that it might increase bleeding when surgery or invasive procedures are required.

Methods and Results—

The current analysis was undertaken to compare the periprocedural bleeding risk of patients in the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) trial treated with dabigatran and warfarin. Bleeding rates were evaluated from 7 days before until 30 days after invasive procedures, considering only the first procedure for each patient. A total of 4591 patients underwent at least 1 invasive procedure: 24.7% of patients received dabigatran 110 mg, 25.4% received dabigatran 150 mg, and 25.9% received warfarin,
P
=0.34. Procedures included: pacemaker/defibrillator insertion (10.3%), dental procedures (10.0%), diagnostic procedures (10.0%), cataract removal (9.3%), colonoscopy (8.6%), and joint replacement (6.2%). Among patients assigned to either dabigatran dose, the last dose of study drug was given 49 (35–85) hours before the procedure on comparison with 114 (87–144) hours in patients receiving warfarin,
P
<0.001. There was no significant difference in the rates of periprocedural major bleeding between patients receiving dabigatran 110 mg (3.8%) or dabigatran 150 mg (5.1%) or warfarin (4.6%); dabigatran 110 mg versus warfarin: relative risk, 0.83; 95% CI, 0.59 to 1.17;
P
=0.28; dabigatran 150 mg versus warfarin: relative risk, 1.09; 95% CI, 0.80 to 1.49;
P
=0.58. Among patients having urgent surgery, major bleeding occurred in 17.8% with dabigatran 110 mg, 17.7% with dabigatran 150 mg, and 21.6% with warfarin: dabigatran 110 mg; relative risk, 0.82; 95% CI, 0.48 to 1.41;
P
=0.47; dabigatran 150 mg: relative risk, 0.82; 95% CI, 0.50 to 1.35;
P
=0.44.

Conclusions—
Dabigatran and warfarin were associated with similar rates of periprocedural bleeding, including patients having urgent surgery. Dabigatran facilitated a shorter interruption of oral anticoagulation.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT00262600.
The type III secretion system is necessary for the development of a pathogenic and endophytic interaction between Herbaspirillum rubrisubalbicans and Poaceae
Authors: Schmidt Maria Augusta , Balsanelli Eduardo , Faoro Hellison , Cruz Leonardo M , Wassem Roseli , de Baura Valter A , Weiss Vinícius , Yates Marshall G , Madeira Humberto M F , Pereira-Ferrari Lilian , Fungaro Maria H P , de Paula Francine M , Pereira Luiz F P , Vieira Luiz G E , Olivares Fábio L , Pedrosa Fábio O , de Souza Emanuel M , Monteiro Rose A 
Published: June 2012

Abstract

Background

Herbaspirillum rubrisubalbicans was first identified as a bacterial plant pathogen, causing the mottled stripe disease in sugarcane. H. rubrisubalbicans can also associate with various plants of economic interest in a non pathogenic manner.

Results
A 21 kb DNA region of the H. rubrisubalbicans genome contains a cluster of 26 hrp/hrc genes encoding for the type three secretion system (T3SS) proteins. To investigate the contribution of T3SS to the plant-bacterial interaction process we generated mutant strains of H. rubrisubalbicans M1 carrying a Tn5 insertion in both the hrcN and hrpE genes. H. rubrisulbalbicans hrpE and hrcN mutant strains of the T3SS system failed to cause the mottled stripe disease in the sugarcane susceptible variety B-4362. These mutant strains also did not produce lesions on Vigna unguiculata leaves. Oryza sativa and Zea mays colonization experiments showed that mutations in hrpE and hrcN genes reduced the capacity of H. rubrisulbalbicans to colonize these plants, suggesting that hrpE and hrcN genes are involved in the endophytic colonization.

Conclusions
Our results indicate that the T3SS of H. rubrisubalbicans is necessary for the development of the mottled stripe disease and endophytic colonization of rice.
Enhancement of musculocutaneous nerve reinnervation after vascular endothelial growth factor (VEGF) gene therapy
Authors: Haninec Pavel , Kaiser Radek , Bobek Vladimír , Dubový Petr 
Published: June 2012

Abstract

Background
Vascular endothelial growth factor (VEGF) is not only a potent angiogenic factor but it also promotes axonal outgrowth and proliferation of Schwann cells. The aim of the present study was to quantitatively assess reinnervation of musculocutaneous nerve (MCN) stumps using motor and primary sensory neurons after plasmid phVEGF transfection and end-to-end (ETE) or end-to-side (ETS) neurorrhaphy. The distal stump of rat transected MCN, was transfected with plasmid phVEGF, plasmid alone or treated with vehiculum and reinnervated following ETE or ETS neurorrhaphy for 2 months. The number of motor and dorsal root ganglia neurons reinnervating the MCN stump was estimated following their retrograde labeling with Fluoro-Ruby and Fluoro-Emerald. Reinnervation of the MCN stumps was assessed based on density, diameter and myelin sheath thickness of regenerated axons, grooming test and the wet weight index of the biceps brachii muscles.

Results
Immunohistochemical detection under the same conditions revealed increased VEGF in the Schwann cells of the MCN stumps transfected with the plasmid phVEGF, as opposed to control stumps transfected with only the plasmid or treated with vehiculum. The MCN stumps transfected with the plasmid phVEGF were reinnervated by moderately higher numbers of motor and sensory neurons after ETE neurorrhaphy compared with control stumps. However, morphometric quality of myelinated axons, grooming test and the wet weight index were significantly better in the MCN plasmid phVEGF transfected stumps. The ETS neurorrhaphy of the MCN plasmid phVEGF transfected stumps in comparison with control stumps resulted in significant elevation of motor and sensory neurons that reinnervated the MCN. Especially noteworthy was the increased numbers of neurons that sent out collateral sprouts into the MCN stumps. Similarly to ETE neurorrhaphy, phVEGF transfection resulted in significantly higher morphometric quality of myelinated axons, behavioral test and the wet weight index of the biceps brachii muscles.

Conclusion
Our results showed that plasmid phVEGF transfection of MCN stumps could induce an increase in VEGF protein in Schwann cells, which resulted in higher quality axon reinnervation after both ETE and ETS neurorrhaphy. This was also associated with a better wet weight biceps brachii muscle index and functional tests than in control rats.
Co-ordinate regulation of cytokinin gene family members during flag leaf and reproductive development in wheat
Authors: Song Jiancheng , Jiang Lijun , Jameson Paula Elizabeth 
Published: June 2012

Abstract

Background
As the global population continues to expand, increasing yield in bread wheat is of critical importance as 20% of the world’s food supply is sourced from this cereal. Several recent studies of the molecular basis of grain yield indicate that the cytokinins are a key factor in determining grain yield. In this study, cytokinin gene family members in bread wheat were isolated from four multigene families which regulate cytokinin synthesis and metabolism, the isopentenyl transferases (IPT), cytokinin oxidases (CKX), zeatin O-glucosyltransferases (ZOG), and β-glucosidases (GLU). As bread wheat is hexaploid, each gene family is also likely to be represented on the A, B and D genomes. By using a novel strategy of qRT-PCR with locus-specific primers shared among the three homoeologues of each family member, detailed expression profiles are provided of family members of these multigene families expressed during leaf, spike and seed development.

Results
The expression patterns of individual members of the IPT, CKX, ZOG, and GLU multigene families in wheat are shown to be tissue- and developmentally-specific. For instance, TaIPT2 and TaCKX1 were the most highly expressed family members during early seed development, with relative expression levels of up to 90- and 900-fold higher, respectively, than those in the lowest expressed samples. The expression of two cis-ZOG genes was sharply increased in older leaves, while an extremely high mRNA level of TaGLU1-1 was detected in young leaves.

Conclusions
Key genes with tissue- and developmentally-specific expression have been identified which would be prime targets for genetic manipulation towards yield improvement in bread wheat breeding programmes, utilising TILLING and MAS strategies.
Transforming growth factor-β suppresses metastasis in a subset of human colon carcinoma cells
Authors: Simms Neka A K , Rajput Ashwani , Sharratt Elizabeth A , Ongchin Melanie , Teggart Carol A , Wang Jing , Brattain Michael G 
Published: June 2012

Abstract

Background
TGFβ signaling has typically been associated with suppression of tumor initiation while the role it plays in metastasis is generally associated with progression of malignancy. However, we present evidence here for an anti-metastatic role of TGFβ signaling.

Methods
To test the importance of TGFβ signaling to cell survival and metastasis we compared human colon carcinoma cell lines that are either non-tumorigenic with TGFβ response (FET), or tumorigenic with TGFβ response (FETα) or tumorigenic with abrogated TGFβ response via introduction of dominant negative TGFβRII (FETα/DN) and their ability to metastasize. Metastatic competency was assessed by orthotopic transplantation. Metastatic colony formation was assessed histologically and by imaging.

Results
Abrogation of TGFβ signaling through introduction of a dominant negative TGFβ receptor II (TGFβRII) in non-metastatic FETα human colon cancer cells permits metastasis to distal organs, but importantly does not reduce invasive behavior at the primary site. Loss of TGFβ signaling in FETα-DN cells generated enhanced cell survival capabilities in response to cellular stress in vitro. We show that enhanced cellular survival is associated with increased AKT phosphorylation and cytoplasmic expression of inhibitor of apoptosis (IAP) family members (survivin and XIAP) that elicit a cytoprotective effect through inhibition of caspases in response to stress. To confirm that TGFβ signaling is a metastasis suppressor, we rescued TGFβ signaling in CBS metastatic colon cancer cells that had lost TGFβ receptor expression due to epigenetic repression. Restoration of TGFβ signaling resulted in the inhibition of metastatic colony formation in distal organs by these cells. These results indicate that TGFβ signaling has an important role in the suppression of metastatic potential in tumors that have already progressed to the stage of an invasive carcinoma.

Conclusions
The observations presented here indicate a metastasis suppressor role for TGFβ signaling in human colon cancer cells. This raises the concern that therapies targeting inhibition of TGFβ signaling may be imprudent in some patient populations with residual TGFβ tumor suppressor activity.