bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early postnatal stress alters extracellular signal‐regulated kinase signaling in the corticolimbic system modulating emotional circuitry in adult rats
Authors: Ishikawa Shuhei , Saito Yasuhiro , Yanagawa Yoshiki , Otani Satoru , Hiraide Sachiko , Shimamura Kei‐ichi , Matsumoto Machiko , Togashi Hiroko 
Published: December 2011

AbstractThe present study elucidated whether early life stress alters the extracellular signal‐regulated kinase (ERK) pathway that underlies fear retrieval and fear extinction based on a contextual fear conditioning paradigm, using a juvenile stress model. Levels of phospho‐ERK (pERK), the active form of ERK, increased after fear retrieval in the hippocampal CA1 region but not in the medial prefrontal cortex (mPFC). ERK activation in the CA1 following fear retrieval was not observed in adult rats who received aversive footshock (FS) stimuli during the second postnatal period (2wFS), which exhibited low levels of freezing. In fear extinction, pERK levels in the CA1 were increased by repeated extinction trials, but they were not altered after extinction retrieval. In contrast, pERK levels in the mPFC did not change during extinction training, but were enhanced after extinction retrieval. These findings were compatible in part with electrophysiological data showing that synaptic transmission in the CA1 field and mPFC was enhanced during extinction training and extinction retrieval, respectively. ERK activation in the CA1 and mPFC associated with extinction processes did not occur in rats that received FS stimuli during the third postnatal period (3wFS), which exhibited sustained freezing behavior. The repressed ERK signaling and extinction deficit observed in the 3wFS group were ameliorated by treatment with the partial N‐methyl‐d‐aspartate receptor agonist d‐cycloserine. These findings suggest that early postnatal stress induced the downregulation of ERK signaling in distinct brain regions through region‐specific regulation, which may lead to increased behavioral abnormalities or emotional vulnerabilities in adulthood.
The modulation of motor cortex excitability during motor imagery depends on imagery quality
Authors: Lebon Florent , Byblow Winston D. , Collet Christian , Guillot Aymeric , Stinear Cathy M. 
Published: December 2011

AbstractMotor imagery (MI) increases corticomotor excitability and modulates intracortical inhibition. This study aimed to relate these neurophysiological mechanisms to imagery quality. Twenty‐three healthy adults participated. First, the ability to vividly and accurately imagine performing a finger‐to‐thumb opposition task was evaluated by calculating a MI index (MII) based on psychological, behavioural and psychophysiological measurements. These scores were used to distinguish good from poor imagers. Transcranial magnetic stimulation was then used to assess modulation of corticomotor excitability, short‐interval intracortical inhibition (sICI) and short‐interval intracortical facilitation (sICF). Participants imagined abduction of their right thumb paced by a 1‐Hz metronome. Single and paired magnetic stimuli were delivered at rest, while listening to the metronome, and during or between imagined movements. Corticomotor excitability was facilitated in the right opponens pollicis for good and poor imagers during MI, and this was positively correlated to the MII score. Poor imagers also facilitated corticomotor excitability of the right abductor digiti minimi, which was not involved in the movement. No interactions were found with sICI and sICF for good imagers, whereas poor imagers recruited intracortical facilitation while imagining. Accurate MI performance was characterised by muscle‐specific temporal modulation of corticomotor excitability.
Single‐lung ventilation with carbon dioxide hemipneumothorax: hemodynamic and respiratory effects in piglets
Authors: Witt Lars , Osthaus Wilhelm Alexander , Schröder Timon , Teich Natascha , Dingemann Carmen , Kübler Joachim , Böthig Dietmar , Sümpelmann Robert 
Published: December 2011

SummaryObjectives:  Video‐assisted thoracoscopic surgery (VATS) has become a standard procedure in pediatric surgery. To facilitate surgical access, the dependent lung has to collapse using intrathoracic carbon dioxide insufflation and/or single‐lung ventilation. These procedures can induce hemodynamic deteriorations in adults. The potential impacts of single‐lung ventilation in combination with capnothorax on hemodynamics in infants have never been studied before.Aim:  We conducted a randomized experimental study focusing on hemodynamic and respiratory changes during single‐lung ventilation with or without capnothorax in a pediatric animal model.Methods:  Twelve piglets were randomly assigned to receive single‐lung ventilation with (SLV‐CO2) or without (SLV) capnothorax with an insufflation pressure of 5 mmHg for a period of two hours. Before, during, and after single‐lung ventilation, hemodynamic and respiratory parameters were measured.Results:  Although mean arterial pressure remained stable during the course of the study and no critical incidents were monitored, cardiac index (CI) decreased significantly with SLV‐CO2 (baseline 3.6 ± 1.6 l·min−1·m−2 vs 2.9 ± 1.1 l·min−1·m−2 at 120 min, P < 0.05). Furthermore, global end‐diastolic volume and intrathoracic blood volume (ITBV) decreased as well significantly with SLV‐CO2, causing a significant between‐group difference in ITBV (P < 0.05).Conclusions:  Despite a decrease in CI and preload parameters, the combination of single‐lung ventilation and low‐pressure capnothorax was well tolerated in piglets and could justify further clinical studies to be performed in infants and children focusing on hemodynamic and respiratory changes during VATS.
The Comparison of Two Recovery Room Warming Methods for Hypothermia Patients Who Had Undergone Spinal Surgery
Authors: Yang Hsiu‐Ling , Lee Hsiu‐Fang , Chu Tsung‐Lane , Su Yu‐Yun , Ho Lun‐Hui , Fan Jun‐Yu 
Published: December 2011

AbstractPurpose: The purpose of this study was to compare the time needed to reach a specified temperature and the efficiency of two warming methods—warm cotton blankets and a radiant warmer—for hypothermia patients in a postanesthetic care unit (PACU) after spinal surgery.Design: This study was conducted according to a quasi‐experimental design. Data were collected from a medical referral center in northern Taiwan. A total of 130 post–spinal surgery patients with hypothermia were recruited in the study.Methods: Of the 130 patients in the PACU, 65 were warmed by the radiant warmer (group R); whereas the other 65 patients were warmed by warm cotton blankets (group B). Tympanic temperature was measured for each patient every 10 min until it reached 36°C in the PACU. Analysis of covariance and generalized estimating equation regression analysis were performed to compare the time needed to reach a specified temperature and the efficiency of the two warming methods, respectively.Findings: Both groups were similar in their baseline characteristics. After adjusting for temperature upon arrival at the PACU, group R needed a significantly shorter time for rewarming to 36°C than group B (F [1, 125]= 58.17, p < .001). The results of the generalized estimating equation also showed that the radiant warmer was more efficient than warm cotton blankets in increasing patients’ body temperatures to 36°C (χ2= 37.44, p < .001). None of the patients appeared to have wound infections, and there were no differences in the length of hospital stay or medical costs for current hospitalization in both groups.Conclusions: Using the radiant warmer may be a more efficient method than providing warm cotton blankets for warming post–spinal surgery hypothermia patients in the PACU.Clinical Relevance: For hospitals that are unable to use forced‐air warming to warm postsurgical hypothermia patients in the PACU, the radiant warmer is a more efficient device to rewarm patients.Journal of Nursing Scholarship, 2011; XX:X, XXX–XXX. ©2011 Sigma Theta Tau International.
A novel technique for tailored surface modification of dental implants – a step wise approach based on plasma immersion ion implantation
Authors: Meirelles Luiz , Uzumaki Emilia Tieko , Lima Jose Henrique Cavalcanti , Muller Carlos Alberto , Albrektsson Tomas , Wennerberg Ann , Lambert Carlos Salles 
Published: December 2011

AbstractObjectivesA novel technique based on plasma immersion ion implantation (PIII) is presented to modify titanium implant surfaces.Materials and methodsInitially, the implants are cleaned with argon to remove contaminants and the nanostructures are created by the bombardment of the surface with a mix of noble gases. Desired crystal structure of the titanium is obtained by the implantation of oxygen on the contaminant‐free surface with particular nanostructures.ResultsIn this study, turned implants modified by PIII revealed a high density of rutile‐TiO2 nanostructures. Turned implants used as control revealed mainly microstructures and amorphous crystal structure. Surface roughness values were similar at the microscale for both turned and turned + PIII implants. Bone response was evaluated by removal torque tests of implants placed in the rabbit tibia and femur. After 4 weeks of healing, turned + PIII demonstrated higher removal torque values (P = 0.001) compared to turned implants.ConclusionsThe presence of rutile‐TiO2 nanostructures may explain the improved bone formation to turned + PIII implants.
Hydroxyapatite pasteOstim®, without elevation of full‐thickness flaps, improves alveolar healing stimulatingBMP‐ andVEGF‐mediated signal pathways: an experimental study in humans
Authors: Canuto R. A. , Pol R. , Martinasso G. , Muzio G. , Gallesio G. , Mozzati M. 
Published: December 2011

AbstractObjectiveTooth extraction is considered as the starting point of jaw atrophy via osteoclast activity stimulation. The maintenance of dental alveolar bone depends on surgery procedure and use of materials to maintain prior space favoring bone regeneration. Among substitutes used in dentistry to fill bone defects,Ostim‐Pastes (Ostim®) is a nanocrystalline paste tested for treatment of severe clinical conditions. This research first investigated the effect ofOstim on alveolar healing, comparing in the same healthy subjects, anOstim®‐filled socket with a not‐filled one. Moreover, it also proposed a new surgical protocol for the post‐extractive socket treatment using the graft materials without elevation of full‐thickness flaps.Material and methodsFourteen patients were enrolled to bilateral maxillary or mandibular extraction that was performed without elevation of full‐thickness flaps. In each patient, one socket was filled usingOstim®, and the other one was allowed to undergo natural healing. No suture was carried out. Clinical and biologic parameters were screened at 1, 7, and 14 days.ResultsObtained results evidenced that nanocrystalline hydroxyapatite supports bone regeneration, increasing the synthesis of pro‐osteogenic factors as bone morphogenetics protein (BMP)‐4,BMP‐7, alkaline phosphatase, and osteocalcin. Moreover, filling post‐extractive socket with nanocrystalline hydroxyapatite paste leads to a complete epithelialization already at 7 days after extraction, despite the fact that the teeth were extracted without elevation of full‐thickness flaps . The improved epithelialization is mediated by increased vascular endothelial growth factor (VEGF) expression. No significant change was observed in inflammatory parameters, with exception of an early and transientIL‐1β induction, that could trigger and improve alveolar healing.ConclusionsClinical and biomolecular observations of this explorative study evidenced that nanocrystalline hydroxyapatite improves alveolar socket healing, increasing angiogenesis, epithelialization, and osteogenesis, also in absence of elevation of full‐thickness flaps.
Quantification of metal artifacts on cone beam computed tomography images
Authors: Pauwels Ruben , Stamatakis Harry , Bosmans Hilde , Bogaerts Ria , Jacobs Reinhilde , Horner Keith , Tsiklakis Kostas 
Published: December 2011

AbstractObjectivesTo quantify metal artifacts obtained from a wide range of cone beam computed tomography (CBCT) devices and exposure protocols, to compare their tolerance to metals of different densities, and to provide insights regarding the possible implementation of metal artifact analysis into a QC protocol for CBCT.Materials and methodsA customized polymethyl methacrylate (PMMA) phantom, containing titanium and lead rods, was fabricated. It was scanned on 13 CBCT devices and one multi‐slice computed tomography (MSCT) device, including high‐dose and low‐dose exposure protocols. Artifacts from the rods were assessed by two observers by measuring the standard deviation of voxel values in the vicinity of the rods, and normalizing this value to the percentage of the theoretical maximum standard deviation.ResultsFor CBCT datasets, artifact values ranged between 6.1% and 27.4% for titanium, and between 10.% and 43.7% for lead. Most CBCT devices performed worse than MSCT for titanium artifacts, but all of them performed better for lead artifacts. In general, no clear improvement of metal artifacts was seen for high‐dose protocols, although certain devices showed some artifact reduction for large FOV or high exposure protocols.ConclusionsRegions in the vicinity of the metal rods were moderately or gravely affected, particularly in the area between the rods. In practice, the CBCT user has very limited possibilities to reduce artifacts. Researchers and manufacturers need to combine their efforts in optimizing exposure factors and implementing metal artifact reduction algorithms.
Bone response to the multilayer BMP‐2 gene coated porous titanium implant surface
Authors: Jiang Qiao‐Hong , Liu Li , Peel Sean , Yang Guo‐Li , Zhao Shi‐Fang , He Fu‐Ming 
Published: December 2011

AbstractObjectivesEvaluate hBMP‐2 expression following gene delivery from plasmid multilayers formed on sandblasted titanium in vitro and bone formation around similarly prepared implant surfaces in vivo.Materials and methodsMultilayers of cationic lipid/rhBMP‐2 plasmid DNA complex (LDc) and anionic hyaluronic acid (HA) was assembled on sandblasted‐dual acid etched pure titanium disks or implant surfaces using layer‐by‐layer (LBL) assembly. Gene delivery and hBMP‐2 expression in cells exposed to the LDc multilayers was measured in vitro. To determine the effect of BMP delivery from such multilyaers in vivo, roughened implants coated with BMP‐2 LDc multilayers or uncoated control implants (n = 15 for both) were implanted in the femurs of NZW rabbits. After 2, 4, 8 weeks, femurs were retrieved and prepared for histomorphometric evaluation (n = 5 rabbits per time point).ResultsMC3T3‐E1 cells cultured directly on the BMP‐2 LDc coated titanium disks showed EGFP and hBMP‐2 expression after 48 h in culture. Increased gene delivery occurred by increasing the number of assembly layers when cells were cultured for 48 h. Cells cultured on LDc coated surfaces had significantly higher cell viability than control cells cultured on uncoated porous titanium surfaces. Histologic observation of the implants showed that after 4 weeks healing, the bone to implant contact (BIC) on the LDc coated surface was much lower than that on the control surface, but didn't reach significant. In contrast, the percentage of bone within the implant's threads was significantly higher than the control group (P = 0.047).ConclusionThe BMP‐2 gene coated sandblasted dual acid etched titanium implants slightly accelerated early bone formation around implants.
Systematic donor blood qualification by flow cytometry would have been able to avoid CLL‐type MBL transmission after unrelated hematopoietic stem cell transplantation
Authors: Ferrand Christophe , Garnache‐Ottou Francine , Collonge‐Rame Marie Agnès , Larosa Fabrice , Blanc Michel , Behar Catherine , Giannoli Catherine , Garnier Frédérico , Tiberghien Pierre , Deconinck Eric , Rohrlich Pierre Simon 
Published: December 2011

AbstractThe current screening for eligibility of unrelated volunteer marrow donors comprises a complete clinical check‐up, a blood CBC and serum protein immunoelectrophoresis. This allows to eliminate acute leukemias, myeloproliferative and myelodysplastic disorders, myelomas and MGUS. To date, the risk of transmission of chronic lymphocytic leukemia (CLL) disease is only evaluated by the clinical evaluation and CBC. We report here the case of a CLL‐type MBL disease occurring in a 12‐year‐old boy after unrelated BMT. Deep biological investigations, as Immunophenotyping, cytogenetic and molecular biology allow us to determine the donor origin of the CLL clone. In 2010, 14.2% donor (105/737) for unrelated hematopoietic stem cell transplantation were over 45y. It is currently estimated (USA) that 1 in 210 men and women will be diagnosed with CLL during their lifetime. Given the long asymptomatic phase of CLL, this raises the case for a detection strategy analog to that used for MGUS and myeloma through serum protein electrophoresis. This case‐report, to our knowledge, of a CLL‐type MBL unrelated donor‐to‐recipient transmission through BMT raises ethical and practical questions, such as the proper information about disease transmission risk. The cost‐effectiveness of a systematic peripheral blood Immunophenotyping in donors elder than 40y at time of stem cell donation should be evaluated.
Fluoxetine-induced tardive dyskinesia in a patient with Parkinson's disease
Authors: Raidoo Deshandra M. 
Published: December 2011

Background: This is a report of a 66-year-old male with Parkinson's disease (PD), depression and anxiety who developed tardive dyskinesia (TD) while on fluoxetine.Methods: The patient underwent psychiatric, neurological and neuroimaging examination.Results: The patient's neuroimaging examination was normal, his psychiatric assessment revealed depression and anxiety, and his neurological evaluation diagnosed only mild PD. The patient's TD resolved when fluoxetine was discontinued and recurred upon re-exposure.Conclusion: This case shows that fluoxetine as monotherapy can be associated with TD especially in patients with concomitant PD. Clinicians must be aware of this side-effect and monitor for features of TD due to antidepressants that are often used to treat comorbid depression in patients with PD.
Determinants of inappropriate complementary feeding practices in young children in Nepal: secondary data analysis of Demographic and Health Survey 2006
Authors: Joshi Nira , Agho Kingsley E. , Dibley Michael J. , Senarath Upul , Tiwari Kalpana 
Published: December 2011

AbstractInappropriate complementary feeding increases the risk of undernutrition, illness and mortality in infants and children. This study uses a subsample of 1428 children of 6–23 months from Nepal Demographic and Health Survey (NDHS), 2006. The 2006 NDHS was a multistage cluster sample survey. The complementary feeding indicators were estimated according to the 2008 World Health Organization recommendations. The rate of introduction of solid, semi‐solid or soft foods to infants aged 6–8 months was 70%. Minimum meal frequency and minimum dietary diversity rates were 82% and 34%, respectively, and minimum acceptable diet for breastfed infants was 32%. Multivariate analysis indicated that working mothers and mothers with primary or no education were significantly less likely to give complementary foods, to meet dietary diversity, minimum meal frequency and minimum acceptable diet. Children living in poor households were significantly less likely to meet minimum dietary diversity and minimum acceptable diet. Mothers who had adequate exposure to media, i.e. who watch television and who listen to radio almost every day, were significantly more likely to meet minimum dietary diversity and meal frequency. Infants aged 6–11 months were significantly less likely to meet minimum acceptable diet [adjusted odds ratio (OR) = 3.13, confidence interval (CI) = 2.16–4.53] and to meet minimum meal frequency (adjusted OR = 4.46, CI = 2.67–7.46). In conclusion, complementary feeding rates in Nepal are inadequate except for minimum meal frequency. Planning and promotion activities to improve appropriate complementary feeding practices should focus on illiterate mothers, those living in poor households, and those not exposed to media.
Determinants of inappropriate complementary feeding practices in young children in India: secondary analysis of National Family Health Survey 2005–2006
Authors: Patel Archana , Pusdekar Yamini , Badhoniya Neetu , Borkar Jitesh , Agho Kingsley E. , Dibley Michael J. 
Published: December 2011

AbstractIn India, poor feeding practices in early childhood contribute to the burden of malnutrition as well as infant and child mortality. This paper aims to use the newly developed World Health Organization (WHO) infant feeding indicators to determine the prevalence of complementary feeding indicators among children of 6–23 months of age and to identify the determinants of inappropriate complementary feeding practices in India. The study data on 15 028 last‐born children aged 6–23 months was obtained from the National Family Health Survey 2005–2006. Inappropriate complementary feeding indicators were examined against a set of child, parental, household, health service and community level characteristics. The prevalence of timely introduction of complementary feeding among infants aged 6–8 months was 55%. Among children aged 6–23 months, minimum dietary diversity rate was 15.2%, minimum meal frequency 41.5% and minimum acceptable diet 9.2%. Children in northern and western geographical regions of India had higher odds for inappropriate complementary feeding indicators than in other geographical regions. Richest households were less likely to delay introduction of complementary foods than other households. Other determinants of not meeting minimum dietary diversity and minimum acceptable diet were: no maternal education, lower maternal Body Mass Index (BMI) (<18.5 kg/m2), lower wealth index, less frequent (<7) antenatal clinic visits, lack of post‐natal visits and poor exposure to media. A very low proportion of children aged 6–23 months in India received adequate complementary foods as measured by the WHO indicators.
Giant dedifferentiated liposarcoma of the right hemifacial area involving the oral cavity
Authors: Stomeo Francesco , Bianchini Chiara , Ciorba Andrea , Padovani Davide , Pedriali Massimo , Pelucchi Stefano , Pastore Antonio 
Published: December 2011

doi: 10.1111/j.1741‐2358.2011.00455.xGiant dedifferentiated liposarcoma of the right hemifacial area involving the oral cavityAlthough liposarcoma is a reasonably common soft tissue sarcoma in adults, its occurrence within the head and neck region is very rare. The following report presents the case of a giant dedifferentiated liposarcoma initially located in the temporal region and then extending to the entire right maxillofacial region. Clinical as well as histopathological features and therapeutic approaches of dedifferentiated liposarcoma are discussed, and a literature review is presented.