bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frontiers in Operations: Optimal Genetic Testing of Families
Authors: Adelman Daniel , Wang Kanix 
Published: June 2024

Problem definition: Through the laws of inheritance, knowing an individual’s genetic status informs disease risk for family members, but current protocols for deciding whom to genetically test only consider one person at a time rather than design an optimal testing plan for the entire family. Methodology/results: We develop a Markov decision process framework for maximizing the net benefits of genetic testing that integrates a Bayesian network of genetic statuses, with a functional representation of cost-effectiveness. Our model provides a contingent sequence of family members to test one at a time, that is, a plan that dynamically incorporates new test results, revealed sequentially at random, to decide who next to test. In the general case, we show that optimal stopping follows a structure with two-sided thresholds, previously known only for individual testing. Although the optimal testing sequence, in general, is contingent on the family test results, in the special case of sibling-only tests we can identify this sequence a priori. Our numerical case study, which was conducted in a realistic BRCA1/2 testing setting, demonstrates that an optimal policy significantly improves cost-effectiveness over existing policies. Thus, our framework offers a promising and powerful new approach to genetic testing. Managerial implications: In an optimal policy, prioritizing testing family members who might otherwise not have been tested can lead to an overall improvement in familial health value, surpassing even the most cost-effective existing protocols. From a management perspective, healthcare organizations and insurance companies can potentially save costs by implementing this approach for such families. History: This paper has been accepted in the Manufacturing & Service Operations Management Frontiers in Operations Initiative. Funding: D. Adelman is grateful for financial support from Booth School of Business. Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2023.0057 .
Highly sensitive surface plasmon resonance sensor based on the anti-resonant fiber with six nested tubes
Authors: Yang Lin , Liu Chao , Fu Haihao , Lv Jingwei , Liu Wei , Wang JianXin , Chu Paul K. 
Published: June 2024

On the heels of the continuous development of optical fiber sensing technology, optical fiber sensors based on surface plasmon resonance (SPR) have attracted widespread attention. Herein, an SPR sensor based on the six nested anti-resonant fiber (ARF) is designed and analyzed by the finite element method (FEM). All the structural parameters are optimized to achieve high-sensitivity liquid refractive index detection. Filling the anti-resonant tube with plasmonic materials to excite SPR can further reduce the manufacturing complexity. The optimal ARF-SPR sensor has excellent characteristics, including an average wavelength sensitivity of 42,000 nm/RIU, maximum sensor length of 0.08 cm, and resolution of 1.61×10−6RIU. The ARF-SPR sensor has great potential in chemical analysis, biomedicine, and other fields.
Understanding interaction in problematic dementia and social care encounters: Protocol for a micro-level study combining video-ethnography and Conversation Analysis (CA)
Authors: Chatwin John , Ludwin Katherine , Jones Danielle , Bravington Alison 
Published: June 2024

Introduction
It is well established that the actions and behaviour of dementia care workers are fundamental to the wellbeing of the people they care for. Not only do they deal with basic healthcare needs, but they also perform a vital psycho-social function by providing–through their regular presence–an underlying continuity for residents. This has been shown to improve well-being, particularly for those in the advanced stages of dementia. It has also been suggested that there are additional psycho-social benefits of such contact which can directly influence the need for anti-psychotic medication. However, unlike most other healthcare and medical settings, the specialised and often difficult interactions that dementia care workers handle every day have not yet been the subject of detailed micro-level analysis. This is particularly significant because much of the impact that care-workers have relates to the way in which they interact with the people they care for. Not having a clear understanding of how their interactions ‘work’ at the micro-level–particularly ones that are specific to dementia care settings, and that care workers report to be difficult or challenging–means that any training interventions that are developed may not resonate with their real-world experience, and ultimately run the risk of failing. This video-based observational study aims to provide a detailed micro-exploration of problematic and challenging interactions involving care-workers and people living with dementia.

Setting and methods
The study is based in the UK and will involve up to 20 dementia care staff and 60 people living with dementia. Fieldwork will be conducted in 5 dementia care home and community-based dementia day care settings using naturalistic observational methods (primarily video-ethnography). Data will be analysed using Conversation Analysis (CA).
Dr. Augustin Krämer: A German Ethnologist in the Pacific, Sven Mönter (2021)
Authors: Thode-Arora Hilke 
Published: June 2024

Review of: Dr. Augustin Krämer: A German Ethnologist in the Pacific, Sven Mönter (2021)
Wiesbaden: Harrassowitz Verlag, 260 pp.,
ISBN 978 3 44711 670 1 (pbk), €68
PERAN SAPTA PESONA BAGI PENGEMBANGAN PARIWISATA DI YOGYAKARTA
Authors: Sudarsih Sri , Widisuseno Iriyanto 
Published: June 2024

ABSTRAKPengabdian masyarakat ini menfokuskan pada peran sapta pesona bagi pengembangan pariwisata di Yogyakarta. Pengabdian pada masyarakat ini ditujukan kepada pengemudi becak wisata sebagai salah satu pelaku pariwisata di Yogyakarta. Metode yang digunakan dalam pengabdian masyarakat ini adalah ceramah dan diskusi interaktif mengenai sapta pesona dan pariwisata. Ceramah dilakukan untuk para pengemudi becak wisata agar memahami tentang peran sapta pesona kaitannya dengan pengembangan pariwisata di Yogyakarta. Sedangkan diskusi interaktif bertujuan agar para pengemudi becak wisata mudah memahami materi dan penerapannya sapta pesona dalam dunia pariwisata. Sapta pesona merupakan nilai-nilai yang mencerminkan rasa aman, tertib, bersih, sejuk, indah, ramah, dan kenangan. Kondisi seperti ini sangat menetukan keberhasilan pembangunan dalam bidang pariwisata. Yogyakarta terkenal dengan tempat wisata yang sangat lengkap, bahkan diiringi kuliner khas daerah ini. Untuk mencapai terwujudnya sapta pesona di kota Yogyakarta ini maka setiap elemen masyarakat dan pemerintah senantiasa berbenah agar para wisatawan merasa nyaman yang ditunjang lingkungan sekitar yang mencerminkan nilai-nilai dasar kepariwisataan sehingga wisatawan merasa nyaman.Kata kunci: pariwisata, pengemudi becak, sapta pesona, nyaman ABSTRACTThis community service focuses on the role of Sapta Pesona for tourism development in Yogyakarta. This community service is aimed at tourist pedicab drivers as one of the tourism actors in Yogyakarta. The method used in this community service is lectures and interactive discussions regarding Sapta Pesona and tourism. The lecture was held for tourist pedicab drivers to understand the role of Sapta Pesona in relation to tourism development in Yogyakarta. Meanwhile, the interactive discussion aims to make it easy for tourist pedicab drivers to understand the material and its application of Sapta Pesona in the world of tourism. Sapta Pesona are values that reflect a sense of security, order, clean, cool, beautiful, friendly and memorable. Conditions like this really determine the success of development in the tourism sector. Yogyakarta is famous for its very complete tourist attractions, even accompanied by culinary specialties from this region. To achieve the realization of Sapta Pesona in the city of Yogyakarta, every element of society and government is always improving so that tourists feel comfortable, supported by the surrounding environment which reflects the basic values of tourism so that tourists feel comfortable.Keywords: tourism, rickshaw drivers, sapta pesona, comfortable
PENGELOLAAN PERPUSTAKAAN SEKOLAH MELALUI PENERAPAN INVENTARISASI, KLASIFIKASI, DAN PRESERVASI KOLEKSI UNTUK MENINGKATKAN AKSES DAN PEMANFAATAN MATERI BACAAN
Authors: Indrahti Sri , Maziyah Siti , Alamsyah Alamsyah , Yuliati Dewi , Nuha Muhammad Ulin , Alfharezi M. Salman , Kautsar Nadafia , Rahayuningrum Hesti 
Published: June 2024

ABSTRAKPerpustakaan sekolah memegang peran krusial dalam mendukung proses pembelajaran siswa dengan memberikan akses ke beragam sumber informasi. Namun, di Sekolah Menengah Pertama Islam Terpadu (IT) Al Fikri, pengelolaan perpustakaan masih belum mencapai tingkat optimal. Dalam upaya memperbaiki masalah ini, kegiatan pengabdian terbagi menjadi inventarisasi, klasifikasi, dan preservasi koleksi buku perpustakaan, serta sosialisasi kepada pustakawan dan staf sekolah mengenai praktik pengelolaan perpustakaan yang baik. Dengan demikian, upaya ini bertujuan untuk meningkatkan efektivitas dan efisiensi pengelolaan perpustakaan sekolah, yang pada gilirannya dapat meningkatkan kualitas pembelajaran dan aksesibilitas informasi bagi siswa. Kata kunci: perpustakaan, sekolah, inventarisasi, klasifikasi, perservasi ABSTRACTSchool libraries play a crucial role in facilitating students' learning processes by providing access to diverse sources of information. However, at the Integrated Islamic Junior High School (IT) Al-Fikri, library management has yet to reach an optimal. To address this issue, outreach activities encompassing inventory, classification, and preservation of library book collections are undertaken, alongside socialization sessions for librarians and school staff on effective library management practices. These efforts aim to enhance the effectiveness and efficiency of school library management, thereby improving the quality of learning and access to information for students. Keywords: library, school, inventory, classification, preservation
Innovative assessment of lipid‐induced oxidative stress and inflammation in harvested human endothelial cells
Authors: Saleem Mohammad , Ahmad Taseer , Haynes Alexandria Porcia , Albritton Claude F. , Mwesigwa Naome , Graber Meghan K. , Kirabo Annet , Shibao Cyndya A. 
Published: June 2024

AbstractStudying acute changes in vascular endothelial cells in humans is challenging. We studied ten African American women and used the J‐wire technique to isolate vein endothelial cells before and after a four‐hour lipid and heparin infusion. Dynamic changes in lipid‐induced oxidative stress and inflammatory markers were measured with fluorescence‐activated cell sorting. We used the surface markers CD31 and CD144 to identify human endothelial cells. Peripheral blood mononuclear cells isolated from blood were used as a negative control. The participants received galantamine (16 mg/day) for 3 months. We previously demonstrated that galantamine treatment effectively suppresses lipid‐induced oxidative stress and inflammation. In this study, we infused lipids to evaluate its potential to increase the activation of endothelial cells, as assessed by the levels of CD54+ endothelial cells and expression of Growth arrest‐specific 6 compared to the baseline sample. Further, we aimed to investigate whether lipid infusion led to increased expression of the oxidative stress markers IsoLGs and nitrotyrosine in endothelial cells. This approach will expedite the in vivo identification of novel pathways linked with endothelial cell dysfunction induced by oxidative stress and inflammatory cytokines. This study describes an innovative method to harvest and study human endothelial cells and demonstrates the dynamic changes in oxidative stress and inflammatory markers release induced by lipid infusion.
Validation of basal metabolic rate equations in persons with innervated and denervated chronic spinal cord injury
Authors: Alazzam Ahmad M. , Gorgey Ashraf S. 
Published: June 2024

AbstractBasal metabolic rate (BMR) measurement is time consuming and requires specialized equipment. Prediction equations allow clinicians and researchers to estimate BMR; however, their accuracy may vary across individuals with chronic spinal cord injury (SCI). The objective of this study was to investigate the validity of SCI‐specific equations as well as able‐bodied (AB) prediction equations in individuals with upper motor neuron (UMN), lower motor neuron (LMN), and females with SCI. Twenty‐six men and women with chronic SCI (n = 12 innervated males, n = 6 innervated females, n = 8 denervated males) participated in this cross‐sectional study. BMR values were measured by indirect calorimetry. Body composition (dual‐energy X‐ray absorptiometry and anthropometrics) assessment was conducted. AB‐prediction equations [Cunningham, Nelson, Owen, Harris and Benedict, Mifflin, Schofield, Henry] and SCI‐specific equations [Chun and Nightingale & Gorgey] were used to estimate and validate BMR. The accuracy of AB‐specific FFM equations in predicting BMR was evaluated using Bland–Altman plots, paired t‐tests, and error metrics. Measured BMR for innervated males, females, and denervated males was 1436 ± 213 kcal/day, 1290 ± 114, and 1597 ± 333 kcal/day, respectively. SCI‐specific equations by Chun et al., Nightingale & Gorgey, and AB‐specific FFM equations accurately predicted BMR for innervated males. For the denervated males, Model 4 equation by Nightingale & Gorgey was not different (p = 0.18), and Bland–Altman analyses showed negative mean bias but similar limits of agreement between measured and predicted BMR for the SCI‐specific equations and AB‐specific FFM equations. We demonstrated that SCI‐specific equations accurately predicted BMR for innervated males but underpredicted it for denervated males. The Model 4 equation by Nightingale & Gorgey accurately estimated BMR in females with SCI. Findings from the current study will help to determine caloric needs in different sub‐groups of SCI.
Physico-chemical properties and durability of a fly-ash-based geopolymer
Authors: Boutkhil Hanane , Fellak Somia , Alehyen Saliha , Bari Ahmed , Fidan Hafize 
Published: June 2024

Abstract
Due to the environmental problems linked to the production of portland cement, the search for new more economic and non-polluting construction materials has become a current issue of interest. Geopolymers represent new types of “polymeric” materials of mineral nature. The aim of this work is to study the influence of the Na2SiO3/NaOH mass ratio and curing time on the mechanical and microstructural properties of fly-ash-based geopolymers GP-Fs. The samples were synthesized with different Na2SiO3/NaOH mass ratios (2.5, 4, and 6) and curing times (2, 12, and 24 h) at 60°C. The GP-F pastes elaborated were analyzed by scanning electron microscopy, Fourier transform infrared (FTIR) spectroscopy, and X-ray diffraction (XRD). The sample with the highest compressive strength and density and the lowest water absorption was produced with a Na2SiO3/NaOH mass ratio of 2.5 and a curing time of 24 h, which is GP1, as confirmed by FTIR and XRD analyses; in addition, it had a compact structure attributed to a higher pozzolanic reactivity. These optimized geopolymer pastes were studied to assess the durability test, evaluating the resistance to fire and acid attack. Fire resistance was assessed by heating the GP-F pastes to 800°C for 2 h, and acid resistance was studied by immersing specimens in a solution of 6% acetic acid (GP-F-CH3COOH) and 6% hydrochloric acid (GP-F-HCl) for 2 months. Physico-chemical and microstructural changes before and after heat and acid exposure were studied using several analyses. Samples exposed to an acidic environment display a completely porous shape with some micro-cracks, inducing a decrease of the residual compressive energy. FTIR analysis showed that the geopolymer gel deformed after heating to 800°C, and pores were formed in their structure due to evaporation of water.
TOC prediction of source rocks based on the convolutional neural network and logging curves – A case study of Pinghu Formation in Xihu Sag
Authors: Jingwen Yan , Wenxiang He , Xiaoyang Gao , Yong Hu 
Published: June 2024

Abstract
The total organic carbon (TOC) content is an important index for source rock evaluation. However, due to the scarcity of rock samples, the vertical continuous TOC change curve cannot be obtained, and the test cost is high, which bring great limitations to the evaluation of source rocks. Predecessors have also studied some TOC prediction models, such as the Δlg R method, support vector regression (SVR), and back-propagation neural network, but the TOC predicted by the Δlg R method and SVR has low accuracy and is difficult to calculate. However, back-propagation neural networks always have problems such as local optimal solution and slow convergence speed. In this article, a convolution neural network prediction scheme is proposed. Taking the source rocks of Pinghu Formation in the Xihu Sag as the research object, the advantages of this method are proved by comparing the prediction results of the Δlg R method, SVR, and BP neural network method. The results show that the prediction accuracy of this method is more than 90%, meeting the prediction requirements of TOC. By predicting the TOC curve of Well A, the TOC variation characteristics of Pinghu Formation are finally obtained.
Experiences about calculating ZIP and exponential load model parameters
Authors: Zhang Yiqi , Liao Yuan , Yadav Gaurav 
Published: June 2024

AbstractTo reduce greenhouse emission and achieve sustainability in the electric power industry, improved efficiency and energy conservation are key to finding a sound solution. Energy conservation through voltage reduction (CVR) is one such program. To implement effective CVR programs, load models are of utmost importance in determining proper feeders and methods to implement the CVR programs. Exponential and polynomial load models stand out as the most widely adopted models. The polynomial load model, often referred to as the ZIP (constant impedance, current and power) model, is especially notable for its ability to represent the relationship between the applied voltage and power consumption. This paper sheds light on the limitations of commonly used ZIP load model estimation methods and highlights the significance of using ap-propriate measurement samples and understanding the true nature of the load. Two distinct ZIP load models, i.e., the regular ZIP (RegZIP) and the Non-traditional ZIP (NTZIP) models, have been used for ZIP parameter estimation. The RegZIP load model consumes equal or more power when voltage increases, while the NTZIP model consumes equal or less power when voltage increases. It is emphasized that the RegZIP is an existing load model and the NTZIP is an artificial load model this research created for comparison purposes. The intention of this paper is not to propose any new load model, but to investigate the implications of choosing the wrong model and the impacts of measurement errors of voltage and power data. The research has shown that the two different models can fit the same measurement data equally well for some measured data. The results have demonstrated that simply using certain methods such as the optimization method for estimating load model parameters using unfiltered real time measurements may yield misleading and unreliable results. Wrong load models will inevitably lead to wrong CVR assessment. Identifying the correct measurement samples, obtained during natural or staged events causing substantial voltage variations, is critically important in calculating load parameters and ensure the soundness of the obtained results. The accurate load parameters will be important in the assessment of CVR program effectiveness and will ensure that power system analysis applications that utilize the load models will provide reliable results.
Fiscal Control Management Indicators, Opportunities, and Challenges for Their Implementation
Authors: Hernández Burbano María José , Ortiz Cubillos José Lizardo 
Published: June 2024

With the promulgation of Legislative Act 04/2019, whereby the fiscal control system in Colombia is reformed, and the issuance of Decree 403/2020, whereby its implementation is regulated, a great expectation has soared about the construction of a new vision of fiscal control and how its surveillance bodies must fulfill the commitments acquired by Colombia under its accession to the OECD. For this purpose, the main assumptions of the reform and the current constitutional postulates will be identified. This will serve as a normative scenario to explore the options and challenges of the reformed fiscal control regime regarding creating public value based on the implementation management indicators technique. The analysis and conceptual developments of the study intend to make a methodological contribution to the fiscal control bodies and to the National Government itself so that in implementing the reform, it incorporates a holistic view of the measurement of the control of the public sphere.
It is, in short, an invitation to reflect on the effectiveness of the instruments applied in the public sector, both regarding the measurement of impacts and the achievement of results in the country’s development policies.
Ensino Médio integrado à Educação Profissional
Authors: Ferretti Celso João 
Published: June 2024

O artigo aborda duas políticas públicas, a primeira de caráter mais recente (o Novotec Integrado) e a segunda vigente desde 2008 (a ação do junto aos Institutos Federais de Educação), estando ambas referidas ao Ensino Médio e à relação entre este e a Educação Profissional. Conclui-se que, em ambos os casos, ocorre a constituição de um processo insidioso e controverso de defesa do Ensino Médio Integrado à Educação Profissional, bem como de sua concepção e, ao mesmo tempo, sua inviabilização.
A Rare Occurrence of Ewing’s Sarcoma Presenting as Breast Mass: A Case Report and Literature Review
Authors: Thakur Ritu , Venugopal Ravi , Sharma Jyoti , Barwad Adarsh 
Published: June 2024

Ewing’s sarcoma (EWS) typically involves the bony structures in adolescents and young adults. Extraskeletal sarcoma is a rare, aggressive, and malignant soft-tissue tumor with high recurrence rate. EWS of the breast is a rare entity with <1% cases reported in literature. A 55-year-old lady who complained of the gradual onset painless breast lump lasting for 1 year was referred to our institute in August 2021. Diagnostic ultrasound of bilateral breast identified a cystic lesion measuring 1.8 × 1.5 cm in lower inner quadrant of right breast. Diagnostic excisional biopsy of the right breast lump, which was conducted outside of the institute, showed malignant small round cell tumor. Post-excisional biopsy whole body 18-fluoro-deoxy-glucose positron emission tomography showed no residual uptake with no evidence of metastatic disease elsewhere. Immunohistochemistry work revealed positive expression of NKX2.2 and MIC2, which is consistent with the histopathological feature of EWS. Fluorescent in situ hybridization showed EWSR1 rearrangement, which is consistent with the diagnosis of EWS. The patient underwent a wide local excision of the right breast, followed by adjuvant chemotherapy consisting of 18 weekly vincristine/adriamycin D/cyclophosphamide regimen (vincristine, total dose of 2 mg; adriamycin D 100 mg; and cyclophosphamide 1.6 g). The patient was disease free after follow-up of 1 year. The rarity of primary breast EWS poses a diagnostic dilemma and hence the treatment. Local control with systemic therapy is the cornerstone of the treatment, in which breast conservation surgery is equivalent to mastectomy in patient with a good/average breast volume.