bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of personality on active and passive use of social networking sites
Authors: Pagani Margherita , Hofacker Charles F. , Goldsmith Ronald E. 
Published: April 2011

AbstractManagers are more and more interested in social networking sites because they provide opportunities for strengthening relationships with customers as well as site content and service. Using social networking sites effectively, however, depends on understanding both the psychological attributes and social interactions of participants. This paper addresses these topics by presenting the results of a two‐study inquiry into the importance of two personality traits (consumer innovativeness and expressiveness) to active and passive use of social networks among Italian consumers. In Study 1 (n = 753) it was found that innovativeness is positively related to active and passive use. Study 2 (n = 277) revealed that self‐identity expressiveness and social identity expressiveness positively influence only active use. These results suggest that managers need to distinguish bet‐ween, and differentially encourage, joining and browsing such sites on the one hand and actively contributing to them on the other. Managers can also enhance the impact of their social networking sites by taking into account social and self‐identity expressiveness to increase affiliation and market share and by encouraging consumers to use these sites actively. © 2011 Wiley Periodicals, Inc.
The effects of cognitive thinking style and ambient scent on online consumer approach behavior, experience approach behavior, and search motivation
Authors: Vinitzky Gideon , Mazursky David 
Published: April 2011

AbstractThis study evaluates the effect of the interaction between cognitive variables and the presence of scent on online search motivation, purchase characteristics, and telepresence. An interaction between consumers' type of thought process and the presence of scent was identified as influencing search motivation (attention focus and challenge) and telepresence experience. Ambient scent influenced the search motivation of consumers possessing systematic cognitive thinking style (SCTS) and the telepresence experience of consumers with intuitive cognitive thinking style (ICTS). In addition, much in the same way that ambient scent affects consumer behavior in traditional stores, in online settings consumers exposed to scent were found to demonstrate a higher degree of approach behavior. The results suggest extending the S‐O‐R model by emphasizing cognitive thinking style as a mediator of environmental stimuli. © 2011 Wiley Periodicals, Inc.
Ionization techniques in capillary electrophoresis‐mass spectrometry: Principles, design, and application
Authors: Hommerson Paul , Khan Amjad M. , de Jong Gerhardus J. , Somsen Govert W. 
Published: April 2011

AbstractA major step forward in the development and application of capillary electrophoresis (CE) was its coupling to ESI‐MS, first reported in 1987. More than two decades later, ESI has remained the principal ionization technique in CE–MS, but a number of other ionization techniques have also been implemented. In this review the state‐of‐the‐art in the employment of soft ionization techniques for CE–MS is presented. First the fundamentals and general challenges of hyphenating conventional CE and microchip electrophoresis with MS are outlined. After elaborating on the characteristics and role of ESI, emphasis is put on alternative ionization techniques including sonic spray ionization (SSI), thermospray ionization (TSI), atmospheric pressure chemical ionization (APCI), atmospheric pressure photoionization (APPI), matrix‐assisted laser desorption ionization (MALDI) and continuous‐flow fast atom bombardment (CF‐FAB). The principle of each ionization technique is outlined and the experimental set‐ups of the CE–MS couplings are described. The strengths and limitations of each ionization technique with respect to CE–MS are discussed and the applicability of the various systems is illustrated by a number of typical examples. © 2010 Wiley Periodicals, Inc., Mass Spec Rev 30:1096–1120, 2011
Cysteinyl‐glycine reduction as marker for levodopa‐induced oxidative stress in Parkinson's disease patients
Authors: Müller Thomas , Muhlack Siegfried 
Published: April 2011

AbstractOxidative stress is influenced by the thiol homeostasis, which determines the redox milieu. One of its components is Cysteinyl‐glycine (Cys‐Gly) generation, as its metabolic precursor is the free radicals scavenging glutathione. Levodopa is under suspicion to promote oxidative stress via the turnover of its metabolite dopamine in abundant mitochondria. Objective was to investigate the impact of levodopa on Cys‐Gly plasma metabolism. Fifteen patients with Parkinson's disease orally took one 200‐mg levodopa/50‐mg carbidopa (CD) containing tablet. Levodopa, its derivative 3‐O‐methyldopa (3‐OMD), and free Cys‐Gly were measured at baseline, 60 and 120 min following levodopa/CD administration. Cys‐gly concentrations decreased, levodopa and 3‐OMD levels increased. Inverse relationships appeared between computed differences of Cys‐gly and 3‐OMD bioavailability. We conclude that Cys‐Gly decline is related to levodopa metabolism to 3‐OMD. Cys‐Gly decay may result from the alternative transformation of glutathione to its oxidized form glutathione dissulfide as consequence of free radical scavenging. © 2011 Movement Disorder Society
Differential Virtual Screening (DVS) with Active and Inactive Molecular Models for Finding and Profiling GPCR Modulators: Case of the CCK1 Receptor
Authors: Diaz Constantino , Leplatois Pascal , Angelloz‐Nicoud Patricia , Lecomte Marinette , Josse Annick , Delpech Monique , Pecceu Florence , Loison Gérard , Shire David , Pascal Marc , Ferrara Pascual , Ferran Edgardo 
Published: April 2011

AbstractWe discovered a constitutively activating mutation (CAM) V308E for the neurotensin NT1 receptor. Molecular dynamics (MD) performed for the CAM NT1‐V308E exhibiting a high spontaneous activity, and for the wild‐type NT1 without basal activity, show dramatic conformational changes for the CAM. To test if the two MD models could be valuable active and inactive templates for building molecular models for other class‐A GPCR, supposed active and inactive models were built by homology for the cholecystokinin CCK1 receptor. Virtual screening of a corporate library with 250 000 compounds was performed with the two CCK1 models, and a differential virtual screening analysis (DVS), led us to isolate 250 predicted agonists and 250 predicted antagonists. The two sets were merged and the compounds were tested in CCK1 agonist and antagonist cellular assays. An excellent correlation was obtained between predictions and biological results. The effective profiling provided by DVS with active and inactive molecular models, opens new perspectives for finding agonists and antagonists for other class‐A GPCR, notably for orphan GPCRs for which no ligands are known.
Prevention of muscle disuse atrophy by MG132 proteasome inhibitor
Authors: Jamart Cecile , Raymackers Jean‐Marc , Li An Gang , Deldicque Louise , Francaux Marc 
Published: April 2011

AbstractIntroduction: Our goal was to determine whether in vivo administration of the proteasome inhibitor MG132 can prevent muscle atrophy caused by hindlimb unloading (HU). Methods: Twenty‐seven NMRI mice were assigned to a weight‐bearing control, a 6‐day HU, or a HU+MG132 (1 mg/kg/48 h) treatment group. Results: Gastrocnemius wasting was significantly less in HU+MG132 mice (−6.7 ± 2.0%) compared with HU animals (−12.6 ± 1.1%, P = 0.011). HU was also associated with an increased expression of MuRF‐1 (P = 0.006), MAFbx (P = 0.001), and USP28 (P = 0.027) mRNA, whereas Nedd4, E3α, USP19, and UBP45 mRNA did not change significantly. Increases in MuRF‐1, MAFbx, and USP28 mRNA were largely repressed after MG132 administration. β5 proteasome activity tended to increase in HU (+16.7 ± 6.1%, P = 0.086). Neither β1 and β2 proteasome activities nor ubiquitin‐conjugated proteins were changed by HU. Conclusions: Our results indicate that in vivo administration of MG132 partially prevents muscle atrophy associated with disuse and highlight an unexpected regulation of MG132 proteasome inhibitor on ubiquitin‐ligases. Muscle Nerve, 2011
The muscle‐hypertrophic effect of clenbuterol is additive to the hypertrophic effect of myostatin suppression
Authors: Kim Kyung Ho , Kim Yong Soo , Yang Jinzeng 
Published: April 2011

AbstractIntroduction:In this study we investigated the combined effect of myostatin (MSTN) suppression and β‐agonist (clenbuterol) administration on muscle hypertrophy and the phosphorylation of muscle 4E‐BP1 and p70S6k, two downstream effectors of the Akt/mTOR anabolic pathway.Methods:Female heterozygous MSTN‐prodomain transgenic mice (an MSTN suppression model) and wild‐type littermates were given 0 or 20 ppm of clenbuterol (CL) in their drinking water, and muscle samples were collected at 1 and 2 weeks after treatment.Results:CL increased body and muscle mass in both genotypes. Levels of phosphorylated muscle 4E‐BP1 and p70S6k were higher in MSTN‐prodomain transgenic mice than in wild‐type mice. CL increased the phosphorylation of 4E‐BP1 and p70S6k in both genotypes.Conclusions:The muscle‐hypertrophic effect of CL is additive to the effect of MSTN suppression. The combination of MSTN suppression and treatment with β‐agonists may be an effective therapeutic approach to combat muscle‐wasting conditions. Muscle Nerve, 2011
Potentiation of the triceps brachii during voluntary submaximal contractions
Authors: Smith Cameron B. , Cheng Arthur J. , Rice Charles L. 
Published: April 2011

AbstractIntroduction: The effects of postactivation potentiation (PAP) on evoked contractions are well understood, but less is known about the effect of PAP on voluntary submaximal contractions. Using a measure of neuromuscular efficiency (NME) [NME = (mV EMG / Nm torque)] we explored the effects of PAP in the triceps brachii at two muscle lengths. Methods: Evoked twitch and NME were compared at short (40° elbow flexion) and long (120°) muscle lengths. At each length, 12 subjects performed a contraction of 25% maximum voluntary contraction (MVC) torque before and after a potentiating MVC. Results: Twitch torque potentiated more at short length (216.9 ± 169.3%) than at long length (77.3 ± 32.6%), but PAP moderately improved NME only at short length (12.2 ± 8.7%). Conclusions: The greater capacity for PAP at the short length is reflected by greater NME. Compared with evoked responses, the relatively small change in NME suggests a different and more modest role of PAP during voluntary submaximal contractions. Muscle Nerve, 2011
Loss of BAF250a (ARID1A) is frequent in high‐grade endometrial carcinomas
Authors: Wiegand Kimberly C , Lee Anna F , Al‐Agha Osama M , Chow Christine , Kalloger Steve E , Scott David W , Steidl Christian , Wiseman Sam M , Gascoyne Randy D , Gilks Blake , Huntsman David G 
Published: April 2011

AbstractMutation of the ARID1A gene and loss of the corresponding protein BAF250a has recently been described as a frequent event in clear cell and endometrioid carcinomas of the ovary. To determine whether BAF250a loss is common in other malignancies, immunohistochemistry (IHC) for BAF250a was performed on tissue microarrays (TMAs) in more than 3000 cancers, including carcinomas of breast, lung, thyroid, endometrium, kidney, stomach, oral cavity, cervix, pancreas, colon and rectum, as well as endometrial stromal sarcomas, gastrointestinal stromal tumours, sex cord‐stromal tumours and four major types of lymphoma (diffuse large B cell lymphoma, primary mediastinal B cell lymphoma, mantle cell lymphoma and follicular lymphoma). We found that BAF250a loss is frequent in endometrial carcinomas but infrequent in other types of malignancies, with loss observed in 29% (29/101) of grade 1 or 2 and 39% (44/113) of grade 3 endometrioid carcinomas of the endometrium, 18% (17/95) of uterine serous carcinomas and 26% (6/23) of uterine clear cell carcinomas. Since endometrial cancers showed BAF250a loss, we stained whole tissue sections for BAF250a expression in nine cases of atypical hyperplasia and 10 cases of atypical endometriosis. Of the nine cases of complex atypical endometrial hyperplasia, all showed BAF250a expression; however, of 10 cases of atypical endometriosis (the putative precursor lesion for ovarian clear cell and endometrioid carcinoma), one case showed loss of staining for BAF250a in the atypical areas, with retention of staining in areas of non‐atypical endometriosis. This was the sole case that recurred as an endometrioid carcinoma, indicating that BAF250a loss may be an early event in carcinogenesis. Since BAF250a loss is seen in endometrial carcinomas at a rate similar to that seen in ovarian carcinomas of clear cell and endometrioid type, and is uncommon in other malignancies, we conclude that loss of BAF250a is a particular feature of carcinomas arising from endometrial glandular epithelium. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Rituximab in combination with multiagent chemotherapy for Pediatric follicular lymphoma
Authors: Kumar Riten , Galardy Paul J. , Dogan Ahmet , Rodriguez Vilmarie , Khan Shakila P. 
Published: April 2011

AbstractGiven the rarity of follicular lymphoma (FL) in children, there is limited data on which to base treatment recommendations. Herein, we report our institutional experience of using rituximab with multiagent chemotherapy for pediatric FL. Six pediatric patients were diagnosed with FL from 2000 to 2009. All patients received rituximab in combination with cyclophosphamide, doxorubicin, vincristine, and prednisone (R‐CHOP) for varying durations. Five of the six patients remain in remission with a median follow‐up of 31 months. Larger randomized trials are indicated to establish the efficacy of this regimen for pediatric FL patients. Pediatr Blood Cancer 2011; 57: 317–320. © 2011 Wiley‐Liss, Inc.
Biomarker discovery and proteomic evaluation of cadmium toxicity on a collembolan species,Paronychiurus kimi(Lee)
Authors: Son Jino , Lee Sung‐Eun , Park Byeoung‐Soo , Jung Jinho , Park Hyung Soon , Bang Joo Young , Kang Gum‐Yong , Cho Kijong 
Published: April 2011

AbstractThe goal of this study was to identify promising new biomarkers of cadmium by identifying differentially expressed proteins inParonychiurus kimiafter exposure to cadmium. Through proteomic analysis ofP. kimiusing 1‐D PAGE and nano‐LC‐MS/MS, 36 downregulated proteins and 40 upregulated proteins were found. Some of the downregulated and upregulated proteins were verified by LC‐MS/MS analysis after 2‐D PAGE. Downregulated proteins in response to cadmium exposure were involved in glycolysis and energy metabolism, chaperones, transcription, reproduction, and neuron growth. In contrast, proteins involved in glycolysis and energy production, neurogenesis, defense systems response to bacteria, and protein biosynthesis were upregulated in cadmium‐treated collembolans. Cubulin may be a potential biomarker for the detection of cadmium inP. kimisince this biomarker was able to low levels (3.5 mg/kg) of cadmium. The 14‐3‐3 ζ was also found to be a potential biomarker for the detection of medium levels (14 mg/kg) of cadmium. Collembolans may be an alternative tool to humans because many collembolans proteins show a high homology to human proteins.
Identification of a novel protein isoform derived from cancer‐related splicing variants using combined analysis of transcriptome and proteome
Authors: Hatakeyama Keiichi , Ohshima Keiichi , Fukuda Yorikane , Ogura Shun‐ichiro , Terashima Masanori , Yamaguchi Ken , Mochizuki Tohru 
Published: April 2011

AbstractSplicing variation enhances proteome diversity and modulates cancer‐associated proteins. Thus, the identification of alternative splice forms is significant for discovery of new cancer‐related biomarkers. However, relatively few screening approaches of alternative splicing via proteomics have been reported. In the present study, we describe a combined analysis with proteome and transcriptome to simultaneously identify cancer‐related splicing variants and splicing variant‐derived protein fragments that are differentially expressed in a highly metastatic gastric cancer cell line MKN45P versus its parental cell line MKN45. We found three potential alternative‐spliced genes using MS‐based shotgun method and two different microarray platforms. Among them, aldolase C, fructose‐bisphosphate (ALDOC) was predicted to have novel alternative splice forms. We successfully identified and validated novel splice forms of ALDOC gene by RT‐PCR and DNA sequencing analyses, the expression level of which were higher in MKN45P than in MKN45. Furthermore, the protein fragment derived from the validated splicing variant was identified using custom‐built data set including sequences of ALDOC variants in MS/MS analysis. Our combined analysis will be a promising technique for screening of cancer‐related splicing variants and their protein isoforms.
Tuning the mechanical properties in model nanocomposites: Influence of the polymer‐filler interfacial interactions
Authors: Chevigny Chloé , Jouault Nicolas , Dalmas Florent , Boué François , Jestin Jacques 
Published: April 2011

AbstractThis article presents a study of the polymer‐filler interfacial effects on filler dispersion and mechanical reinforcement in Polystyrene (PS)/silica nanocomposites by direct comparison of two model systems: ungrafted and PS‐grafted silica dispersed in PS matrix. The structure of nanoparticles has been investigated by combining small angle neutron scattering measurements and transmission electronic microscopic images. The mechanical properties were studied over a wide range of deformation by plate–plate rheology and uni‐axial stretching. At low silica volume fraction, the particles arrange, for both systems, in small finite size nonconnected aggregates and the materials exhibit a solid‐like behavior independent of the local polymer‐fillers interactions suggesting that reinforcement is dominated by additional long range effects. At high silica volume fraction, a continuous connected network is created leading to a fast increase of reinforcement whose amplitude is then directly dependent on the strength of the local particle–particle interactions and lower with grafting likely due to deformation of grafted polymer. © 2011 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2011
A rare association of inlet patch with laryngospasm:
Authors: di Palmo E. , Cazzato S. , Tursini S. , Salfi N.C.M , Mazzotta A. , Di Silverio Carulli C. , Lima M. , Bergamaschi R. , Bernardi F. , Cicognani A. 
Published: April 2011

AbstractThe inlet patch (IP) is an area of heterotopic gastric mucosa in the cervical esophagus commonly seen during upper endoscopy. Although generally asymptomatic IP has been associated with esophageal and supraesophageal symptoms and, though rare, in adult with malignant transformation. We describe two cases of recurrent episodes of laryngospasm associated with IP. In both cases there was a good response to prolonged acid suppression therapy. Pediatr. Pulmonol. 2011; 46:934–938. © 2011 Wiley‐Liss, Inc.
Holographic insights and puzzles
Authors: Hubeny V. 
Published: April 2011

AbstractThe talk is composed of two parts, both set within the AdS/CFT context. In the first part, I discuss holographic insight into strongly coupled field theory in a black hole background. I conjecture two new gravitational solutions, dubbed black funnels and black droplets, which describe two distinct deconfined phases in the field theory at finite temperature. I also briefly mention puzzles associated with an analogous set‐up in a rotating black hole background. In the second part of the talk, I discuss time‐dependent states in a CFT on flat spacetime background, exemplified by the conformal soliton flow. Here I focus on puzzles regarding the nature of entropy in time‐evolving states and its holographic dual.
Incorporation of evolutionary information into Rosetta comparative modeling
Authors: Thompson James , Baker David 
Published: April 2011

AbstractPrediction of protein structures from sequences is a fundamental problem in computational biology. Algorithms that attempt to predict a structure from sequence primarily use two sources of information. The first source is physical in nature: proteins fold into their lowest energy state. Given an energy function that describes the interactions governing folding, a method for constructing models of protein structures, and the amino acid sequence of a protein of interest, the structure prediction problem becomes a search for the lowest energy structure. Evolution provides an orthogonal source of information: proteins of similar sequences have similar structure, and therefore proteins of known structure can guide modeling. The relatively successful Rosetta approach takes advantage of the first, but not the second source of information during model optimization. Following the classic work by Andrej Sali and colleagues, we develop a probabilistic approach to derive spatial restraints from proteins of known structure using advances in alignment technology and the growth in the number of structures in the Protein Data Bank. These restraints define a region of conformational space that is high‐probability, given the template information, and we incorporate them into Rosetta's comparative modeling protocol. The combined approach performs considerably better on a benchmark based on previous CASP experiments. Incorporating evolutionary information into Rosetta is analogous to incorporating sparse experimental data: in both cases, the additional information eliminates large regions of conformational space and increases the probability that energy‐based refinement will hone in on the deep energy minimum at the native state. Proteins 2011; © 2011 Wiley‐Liss, Inc.
Reversed sequence enhances antimicrobial activity of a synthetic peptide
Authors: Gopal Ramamourthy , Kim Young Jin , Seo Chang Ho , Hahm Kyung‐Soo , Park Yoonkyung 
Published: April 2011

AbstractA class of cationic antimicrobial peptides involved in host defense consists of sequences rich in Lys and Trp. Small peptides, (WK)3 and (KW)3, were designed by the combination of alternating Lys (K) and Trp (W) amino acids, and then their antimicrobial and hemolytic activities were determined. It was noticed that the reversed sequence of (KW)3 showed more activity against all strains than did (WK)3. The non‐hemolytic behavior of (WK)3 is identical to that of the reversed analog of (KW)3. CD spectra revealed that these peptides had an unfolded structure in buffer and EYPC:CH (10:1, w/w), but adopted folded conformation in the presence of EYPE:EYPG (7:3, w/w). The reversed‐(KW)3 peptide caused a higher extent of calcein release from EYPE:EYPG (7:3, w/w), though the activity was higher than that of the (WK)3. The interaction of the peptides with model lipid vesicles was examined using Trp fluorescence. The reversed‐(KW)3 showed higher interaction with EYPE:EYPG (7:3, w/w) membrane than did (WK)3. Both the peptides show less affinities while binding to EYPC:CH (10:1, w/w). This clearly indicated that the reversal of sequence factors is relevant to increased antimicrobial activity and lipid membrane permeability. Copyright © 2011 European Peptide Society and John Wiley & Sons, Ltd.
On the performance of different control charting rules
Authors: Riaz Muhammad , Mehmood Rashid , Does Ronald J. M. M. 
Published: April 2011

AbstractIn the literature a number of control charting rules are proposed to decide whether a process is in control or out of control. Some issues with these rules will be highlighted in this article. By redefining and listing a set of rules we will evaluate their performance on the , R, S and S2 charts. Also we will compare the performance of these rules using their power curves to figure out the superior ones. Application of a few of these rules with real data sets will show their detection ability and use for practitioners. Copyright © 2011 John Wiley & Sons, Ltd.