bluuebunny/crossref_metadata_2025_split huggingface dataset:
Method for Pressure Relief in Deep Coal Mine Roadways Using Borehole Groups and Its Application to Guqiao Coal Mine
Authors: Li Yinyu , Qing Li , Kang Yongshui , Zhang Rui , Li Xiang , Liu Bin , Geng Zhi 
Published: April 2024

Abstract
With the increase in the mining depth of coal mines in China, the problem of large deformation of roadways owing to high-ground pressure has become prominent even under enhanced support systems. To reduce the high pressure on the surrounding rock, this study investigates a pressure-relief method for deep roadways using drilling borehole groups. Based on a deep roadway in the Huainan mining area of China, the influences of drilling parameters, such as borehole diameter, length, and arrangement were investigated. The results indicate that the fan-shaped arrangement of the borehole group can compensate for the dilatancy deformation of the surrounding rock. The peak stress of the surrounding rock is reduced and transferred to the inner part of the surrounding rock. Furthermore, a field experiment was conducted on an experimental roadway. The deformation of the roadway was monitored and compared with that of an adjacent roadway that did not apply the pressure-relief method. The monitoring results indicated that the deformation of the experimental roadway was significantly reduced.
A Comparative Study of Machining H13 Steel using different Flank Face Textured Coated Carbide and Ceramic Inserts
Authors: Choudhury Arunabh , Sarma Deba Kumar , Rajbongshi Sanjib Kr 
Published: April 2024

Abstract

Tool life is an important criterion in machining. So, to improve the tool life considering the flank wear, a novel technique of surface texturing is implemented on the flank face of the cutting tool. Two different types of textures viz. dot textures (DT) and groove textures (GT) perpendicular to the cutting edge are fabricated on the flank face of the ceramic and coated carbide tool using micro-electric discharge (µ-EDM) machining. Machining is then carried out on hardened H13 steel with both textured and non-textured (NT) tools. The machining performances are considered as surface roughness, flank wear and cutting temperature which are compared for both coated carbide and the ceramic tool for DT GT and NT. The surface roughness and flank wears during machining with DT are found lesscompared to GT and NT tools for both ceramic and coated carbide. Other hand, surface roughness and flank wears are found less in ceramic tool machining compared to coated carbide tool machining for textured as well as non-textured. The temperature generated at the tool-workpiece interface is higher for the ceramic tool machined surface reveals the formation of white layer which is found more for ceramic tool in terms of thickness and its micro-hardness. The surface produced during machining by textured and non-textured ceramic tool is more lustrous as compared to textured and non-textured coated carbide tool.
Delphi hackathon – a new approach to develop Core Outcome Sets for blood cancers
Authors: Lang Katharina Maria , de Waal Ellen , Bereczky Tamás , Dawoud Dalia , Geissler Jan , Bolanos Natacha , Sanz Guillermo , Guillevic Yann , Rivas Jesus Maria Hernandez , Berg Linda van den , Barbus Martje , Schulze-Rath Renate , Bullinger Lars 
Published: April 2024

Abstract

Background
The Delphi technique is a well-known and accepted method to reach consensus. However, major challenges in Delphi studies include recruiting suitable participants and avoiding a loss of participants between survey rounds. To mitigate these challenges, we developed a virtual “Delphi hackathon” as a new method to conduct Delphi studies. We have used this new approach to develop Core Outcome Sets (COS) for hematologic malignancies within the scope of the HARMONY PLUS project - as part of the HARMONY Alliance,a public-private European Network established in 2017, which currently includes 53 partners and 76 associated members from 26 countries.
Methods
In the style of a classic hackathon, known from software development, we organized two virtual meetings where all participants simultaneously participated in two rounds of online Delphi surveys, followed by a third virtual meeting to reach final consensus. Recruitment of participants was done by advertising and providing information via the HARMONY Alliance communication team and patient umbrella organizations.
Discussion
Big challenges seen in previous Delphi surveys such as difficulties in the recruitment of the various stakeholders to participate in Delphi surveys and their continued support over consecutive Delphi rounds could be favourably addressed by our new Delphi hackathon approach, which showed superior results both with regard to recruitment and continuous support of participants.
The SHOW RESPECT adaptable framework of considerations for planning how to share trial results with participants, based on qualitative findings from trial participants and site staff
Authors: South Annabelle , Snowdon Claire , Burnett Eva , Bierer Barbara E. , Gillies Katie , Isaacs Talia , Sydes Matthew R. 
Published: April 2024

Abstract

Background: Sharing trial results with participants is a moral imperative, but too often does not happen in appropriate ways.
Methods: We carried out semi-structured interviews with patients (n=13) and site staff (n=11) who were part of the Show RESPECT study, which tested approaches to sharing results with participants in the context of the ICON8 ovarian cancer trial (ISRCTN10356387). Data were analysed thematically, and findings used to develop the SHOW RESPECT adaptable framework of considerations for planning how to share trial results with participants. This paper presents the framework, with illustrations drawn from the Show RESPECT study.
Results: Our adaptable “SHOW RESPECT” framework covers: 1) Supporting and preparing trial participants to receive results 2) HOw will the results reach participants? 3) Who are the trial participants? 4) REsults – what do they show? 5) Special considerations 6) Provider – who will share results with participants? 7) Expertise and resources 8) Communication tools 9) Timing of sharing results. While the data upon which the framework is based come from a single trial, many of our findings are corroborated by findings from other studies in this area, supporting the transferability of our framework to trials beyond the UK ovarian cancer setting in which our work took place.
Conclusions: This adaptable “SHOW RESPECT” framework can guide researchers as they plan how to share aggregate trial results with participants. While our data are drawn from a single trial context, the findings from Show RESPECT illustrate how approaches to communication in a specific trial can influence patient and staff experiences of feedback of trial results. The framework generated from these findings can be adapted to fit different trial contexts and used by other researchers to plan the sharing of results with their own participants.
Trial registration: ISRCTN96189403
Show RESPECT was supported by the Medical Research Council (MC_UU_12023/24 and MC_UU_00004/08) and the NIHR CRN.
The therapeutic potential of hemoglobin-based oxygen carriers (HBOC) in the treatment of idiopathic pulmonary fibrosis
Authors: Wang Yi , Cao Min , Qin Qin , Zhao Yanshuang , Zhao Wei , Wang Hailian , Zhang Jinming , Song Siyuan , Huang Xiaobo 
Published: April 2024

Abstract

Idiopathic Pulmonary Fibrosis (IPF) is an unrelenting and progressive lung disorder characterized by the unchecked accumulation of fibrotic tissue within the lung parenchyma, leading to substantial deterioration in pulmonary function and overall survival rates. The complexity of IPF's etiology and the limited efficacy of current treatment modalities underline the critical need for innovative therapeutic strategies. This research assesses the therapeutic viability of Hemoglobin-based Oxygen Carriers (HBOCs) in moderating the severity of pulmonary fibrosis and enhancing oxygenation within a bleomycin-induced IPF mouse model. By focusing on the administration of HBOCs, we meticulously examined their impact on various crucial parameters, including pulmonary function, the extent of fibrotic tissue deposition, inflammatory response, and survival probabilities. The results from our study unequivocally demonstrate that HBOC treatment not only significantly curtails the progression of pulmonary fibrosis but also markedly improves arterial oxygen saturation and diminishes the levels of pro-inflammatory cytokines in the affected mice. These encouraging outcomes underscore HBOCs' potential as an innovative and effective therapeutic avenue for IPF, presenting opportunities to substantially elevate patient well-being and quality of life. Consequently, this investigation adds valuable insights to the accumulating evidence in favor of employing oxygen therapeutic solutions in the management of fibrotic lung conditions and strongly advocates for the continuation of clinical trials to corroborate these promising effects in the context of human IPF.
Experiences of Patients with Endometriosis with a Digital Health Application - a Qualitative Analysis
Authors: Zugaj Marco , Germeyer Ariane , Kranz Karina , Züger Andrea , Keßler Jens 
Published: April 2024

Abstract

Backround
Endometriosis is a frequent disease in women of reproductive age in which the endometrium occurs outside the uterine cavity. Multimodal treatment approaches are necessary due to loss of quality of live and the chronic nature of the disease. Digital health applications (DiGa) are becoming increasingly important. This research project investigates how a healthcare app can influence the subjective experience of illness in patients with endometriosis.
Methods
Empiric data were collected through semi-structured interviews. Data analysis was carried out using qualitative focussed interview analysis. Reliability was ensured by joint interdisciplinary and interprofessional evaluation of the interviews by experts and those affected.
Results
10 patients with endometriosis and the prescribed healthcare app Endo-App© were examined. Categories were defined from the superordinate categories “Factors influencing the experience of illness” and "Evaluation of the app". The app provided reliable information, promoted self-efficacy through exercises and strengthened the perception of the individuality of the illness. It helped to minimise nocebo effects from internet research and enabled a positive change of perspective. Patients criticised the time required for data input and had data protection concerns. The educational elements were often seen as redundant. Some patients only used the app briefly, or not at all.
Conclusion
Once a DiGa has been prescribed, it may be useful to explain its use on an outpatient basis and validate regular use. Blind re-prescribing of DiGas should be avoided. Younger patients with a recent diagnosis or patients following rehabilitation may benefit more from prescribing.
Bulk and single-cell transcriptional profiles reveal roles of fibroblasts and immunocytes in pan-cancer progression
Authors: Sun Yan , Song Bin , Yu Qichao , Yang Huanming , Dong Wei 
Published: April 2024

Abstract

Tumors carry various dysregulated genes, of which many are found to be related to the overall survival of patients. These dysregulated genes are usually identified by bulk transcriptional comparison between tumors and their matching non-tumor tissues. However, because tumor tissues usually contain stromal cells in addition to cancer cells, it remains unclear whether the stromal cells within tumors also carry dysregulated genes. Here, to address this question, we combine bulk and single-cell gene expression data of tumor, adjacent and non-tumor tissues from 7 organs to explore the molecular and cellular mechanism of cancer progression. We found that fibroblasts within tumors across 7 cancer types commonly carry multiple dysregulated genes related to the overall survival of patients. Cell-cell communication analysis revealed significant interactions between cytotoxic immune cells and cancer fibroblasts through the PARs pathway, and self-activation of cancer associated fibroblasts (CAFs) via the PERIOSTIN pathway in pan-cancer. We also identified Colon cancer specific cycling B cells, which influence patients’ survival. Our study provides potential targets for pan-cancer therapy.
Impact of coronavirus disease 2019 (COVID-19) on the perioperative outcomes of maternal and neonatal prognosis: A propensity score-matched analysis
Authors: Yan Feiyi , Wang Jing , Liang Zhuwei , Han Ruquan , Ma Jiajia 
Published: April 2024

Abstract

Introduction:We conducted this study to evaluate the impact of COVID-19 infection on maternal and neonatal prognosis.
Methods: We retrospectively collected data on mothers who underwent emergency cesarean section and their neonates from October 2022 to December 2022. Data on demographic characteristics, comorbidities, and perioperative maternal and neonatal outcomes were collected. Propensity score matching (PSM) was performed with whether the parturient women were infected with COVID-19 (tested positive and combined with at least one of the clinical symptoms related to COVID-19 infectionwas defined as positive, vs tested negative was defined as negative). Outcomes were compared between positive and negative groups.
Results: The study finally consisted of 58 parturient women (n= 29, positive; n = 29, negative). The anaesthesia satisfaction score and postoperative recovery quality score (QoR-15) of the noninfected parturient women group were higher (10 vs 10, P=0.005 and 144 vs 148, P=0.029, respectively). There was a lower incidence of fetal distress in noninfected newborns (17.24% vs 44.83%, OR=3.9, 95% CI 1.163-13.078, P=0.023).
Conclusion: Infection with COVID-19 combined with related clinical symptoms could reduce maternal satisfaction with anaesthesia, postoperative recovery quality scores and with potential increasing risk of fetal distress, but it had no clear impact on neonatal development.
The unique presentation of the relationship between red blood cell folate and appendicular skeletal muscle mass: a cross-sectional study
Authors: Zhang Liangchuan , Peng Yating , Kong Yuan , Zhang Xue , Li Zetian , Jia Hong 
Published: April 2024

Abstract

The overconsumption of folic acid has been associated with deleterious health effects; however, the extant body of research on this matter remains controversial. The principal objective of our investigation was to scrutinize the correlation between red blood cell (RBC) folate levels and appendicular skeletal muscle mass (ASM) among adult individuals. A total of 4117 adults aged over 20 years were included. The weighted prevalence of low muscle mass status (LMMS) was 14.50%. The dose-response relationship between RBC folate and ASM showed an inverted U-shaped curve. When the RBC folate concentration is below 500 nmol/L, ASM increases with increasing RBC folate concentration. However, when the RBC folate level exceeds 500 nmol/L, ASM decreases with increased RBC folate level. After correcting multiple confounding factors, a positive correlation was found between RBC folate and LMMS (p < 0.001). Compared with the RBC folate first quartile, the multivariable-adjusted ORs and 95% CIs of the second quartile, third quartile, and highest quartile were 1.08(0.81–1.44), 1.06(0.79–1.43), and 1.96(1.47–2.61), respectively. Our research suggested that excessive levels of RBC folate increase the risk of LMMS in adults. Thus, being more cautious when considering folic acid supplementation is recommended.
Effect of acid-suppressive drugs on endoscopic transmural drainage of peripancreatic fluid collections - A randomized controlled trial
Authors: Li Yaoting , Yu Tingting , Hou Senlin , zhang Wei , Du Haiming , Hou Yankun , Tian Jiao , Zhang Lichao 
Published: April 2024

Abstract

Background
Acid-suppressing drugs affect intestinal microbes by inhibiting the secretion of stomach acid. However, it is not clear whether acid suppressive drugs affect the microorganisms in the peripancreatic effusion and affect the postoperative complications.
Methods
This study was a prospective randomized controlled trial. A total of 45 patients were enrolled in the trial, and all patients were divided into acid-inhibited and non-inhibited groups. The primary endpoint of our study was to observe the difference of microbiota in the two groups of cyst fluid.
Results
A total of 25 patients were included in the acid-inhibited group and 20 patients were included in the non-acid-inhibited group. There were no significant differences between the two groups in terms of postoperative infection, bleeding, and recurrence rates (p > 0.05). In terms of postoperative C-reactive protein levels, the acid-suppressing group was significantly higher than the non-acid-suppressing group (p < 0.05). In the 16S microbial sequencing analysis, we found no significant difference in α diversity between the antibiotic group and the non-antibiotic group, but there was a statistically significant difference in β diversity between the two groups
Conclusion
Acid-suppressing drugs can change the microbial composition of pancreatic effusions and increase markers of postoperative inflammation. Acid-suppressive drugs may increase the potential infection after endoscopic drainage.
Safety of rituximab biosimilar (Riximyo®) following a single switch from the reference product in patients with Non-Hodgkin’s Lymphoma: A Retrospective Study
Authors: Song Nina K , Musa Hala , Soriano Michael , Hibbs David E , Ramzan Iqbal , Ong Jennifer Ai 
Published: April 2024

Abstract

Introduction: Unlike small molecule drugs and generic products, the active component of biologics and biosimilars are not identical chemical entities. Despite bioequivalence, there is limited evidence in clinical practice (i.e. Phase IV post-marketing surveillance) regarding the safety of biosimilar rituximab and even less so for “switching therapy” with respect to safety, Drug substitution by switching aims to realise cost savings by changing therapy involving a reference (biologic) product to a biosimilar.
Methods: A retrospective analysis of safety outcomes including treatment-emergent adverse effects (TEAEs), rates of death and discontinuation of therapy, for all patients that received switching therapy (from reference to biosimilar rituximab, n=33) was compared to patients who did not did not switch therapy (received biosimilar rituximab only, n=18) at an Australian metropolitan cancer centre, over a six-month period.
Results: There was no statistical significant differences for any safety outcomes examined.
Conclusions: Switching therapy for patients receiving rituximab does not lead to poorer safety outcomes.
Remote delivery of post-graduate allied health professional prescribing education: A survey of the student experience
Authors: George Leslie , Collins Shane 
Published: April 2024

Abstract

The COVID-19 pandemic resulted in a rapid transition of many educational courses to an online delivery model which has not been fully investigated in relation to the student experience. The aim of this study was to explore the learning experience of postgraduate allied health professionals enrolled on an online prescribing programme at an institution within Northern Ireland. A mixed methods cross-sectional survey of postgraduate AHP prescribing students who had undertaken online learning and assessment during the COVID-19 pandemic was carried out. The survey was distributed to 120 students with 51 responses received resulting in a response rate of 42.5%.
There was no statistically significant relationship identified between previous student experience of online learning and overall satisfaction with the current postgraduate programme. Thematic analysis revealed that 82% of respondents described their experience as excellent or very good. Flexibility was highlighted as key factor in student satisfaction allowing materials to be rewatched at preferred times. 80% of respondents answered that they preferred the flipped approach versus live synchronous activities and thematic analysis highlighted that this enhanced the student learning experience. However, a strong theme of social isolation emerged as a significant inhibitor in relation to the student experience and needs to be addressed in future online post-graduate programme delivery.
Colorectal cancer: Identifying molecular subtypes and establishment ofing a novel prognostic model based on metabolic plasticity- and ferroptosis-related gene signatures
Authors: Guan Jingwen , Min Simin , Xia Yan , Guo Zhiguo , Zhou Xiaolan 
Published: April 2024

Abstract

Metabolic plasticity and ferroptosis are essential for colorectal cancer (CRC) progression. The effects and prognostic value of metabolic plasticity- and ferroptosis-related genes (MPFRGs) in CRC remain unclear. We established a prognostic model for CRC patients by identifying important genes in metabolic plasticity and ferroptosis. Data of CRC patients were retrieved from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus; MPFRG data were obtained from GeneCards and FerrDb. We performed functional (to explore differences between the two metabolic subtypes) and single-sample gene set (to assess the immune environment) enrichment analyses. Immunophenotype, tumor immunological dysfunction, and exclusion scores were assessed to determine patient’s immune responses. A least absolute shrinkage and selection operator-Cox regression model comprising 10 significant differentially expressed genes of metabolic plasticity and ferroptosis (MPFDEGs) was constructed using TCGA training cohort and validated using the GSE17536 and GSE39582 datasets. We established a nomogram comprising metabolic plasticity- and ferroptosis-based signatures, revealing the clinical application and potential molecular mechanisms underlying the role of MPFRGs in CRC. Our model (developed based on 10 MPFDEGs) is efficient for calculating the overall survival of CRC patients. Our findings provide new strategies for the clinical management and individualized treatment of CRC patients.
Influence of habitat management and selected environmental parameters on the ground-living communities of harvestmen (Opiliones) in the historical park in Rusovce (Slovakia)
Authors: Litavský Juraj , Majzlan Oto , Langraf Vladimír , Žarnovičan Hubert 
Published: April 2024

Abstract

This study explores the diversity and dynamics of harvestman (Opiliones) communities in the historical park in Rusovce, situated in the southwestern part of Bratislava (Slovakia). Seven study sites were investigated, representing areas subjected to different management practices. The research was conducted from March 2019 to April 2020, using pitfall traps. In total, 2,291 harvestman individuals belonging to 13 species and 4 families were captured. The eudominant species included Nemastoma bidentatum sparsum (Gruber & Martens, 1968), Nelima sempronii Szalay, 1951, and Oligolophus tridens (Koch, 1836). Temperature, both soil and air, emerged as significant factor affecting the spatial structure of harvestman species. The study revealed the response of specific harvestman species to temperature variations, emphasizing the importance of microclimatic conditions. Environmental variables, such as plant species richness in the shrub layer, stand canopy of herb and shrub vegetation layers, and the age of the forest stands, were identified as key factors influencing the dispersal of harvestman species. Furthermore, management practices, especially the presence of invasive plant species and monoculture forests, significantly affected the species composition of harvestmen. Our findings contribute valuable information about the complex interaction between harvestman (Opiliones) communities and environmental factors, habitat characteristics, and management practices. Observing the sensitivity of Opiliones, as important bioindicators, to these factors is crucial for implementing effective conservation strategies in urban green spaces as well as anthropogenically influenced ecosystems.