bluuebunny/crossref_metadata_2025_split huggingface dataset:
Topological analysis of 3D digital ovules identifies cellular patterns associated with ovule shape diversity
Authors: Mody Tejasvinee Atul , Rolle Alexander , Stucki Nico , Roll Fabian , Bauer Ulrich , Schneitz Kay 
Published: May 2024

ABSTRACT
Tissue morphogenesis remains poorly understood. In plants, a central problem is how the 3D cellular architecture of a developing organ contributes to its final shape. We address this question through a comparative analysis of ovule morphogenesis, taking advantage of the diversity in ovule shape across angiosperms. Here, we provide a 3D digital atlas of Cardamine hirsuta ovule development at single cell resolution and compare it with an equivalent atlas of Arabidopsis thaliana. We introduce nerve-based topological analysis as a tool for unbiased detection of differences in cellular architectures and corroborate identified topological differences between two homologous tissues by comparative morphometrics and visual inspection. We find that differences in topology, cell volume variation and tissue growth patterns in the sheet-like integuments and the bulbous chalaza are associated with differences in ovule curvature. In contrast, the radialized conical ovule primordia and nucelli exhibit similar shapes, despite differences in internal cellular topology and tissue growth patterns. Our results support the notion that the structural organization of a tissue is associated with its susceptibility to shape changes during evolutionary shifts in 3D cellular architecture.
Using Machine Learning to Measure Conservatism
Authors: Bertomeu Jeremy , Cheynel Edwige , Liao Yifei , Milone Mario 
Published: May 2024

This study proposes an approach to measure conservatism using machine learning techniques that are not constrained by functional form restrictions. We extend the differential timeliness model to allow for observable characteristics related to conservatism to follow nonlinear relationships. By developing machine learning measures of conservatism, we draw attention to potential benefits and drawbacks and show how its insights complement conventional measures. Our broader goal is to investigate the effectiveness of machine learning algorithms for filtering noise in traditional archival studies and uncovering more complex empirical patterns. This paper was accepted by Suraj Srinivasan, accounting. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2024.4983 .
Outcomes of ilium and iliosacral Ewing’s sarcoma resection reconstructed with tibial strut allograft
Authors: Jamshidi Khodamorad , Toloue Ghamari Babak , Ammar Wael , Mirzaei Alireza 
Published: May 2024

AimsIlium is the most common site of pelvic Ewing’s sarcoma (ES). Resection of the ilium and iliosacral joint causes pelvic disruption. However, the outcomes of resection and reconstruction are not well described. In this study, we report patients’ outcomes after resection of the ilium and iliosacral ES and reconstruction with a tibial strut allograft.MethodsMedical files of 43 patients with ilium and iliosacral ES who underwent surgical resection and reconstruction with a tibial strut allograft between January 2010 and October 2021 were reviewed. The lesions were classified into four resection zones: I1, I2, I3, and I4, based on the extent of resection. Functional outcomes, oncological outcomes, and surgical complications for each resection zone were of interest. Functional outcomes were assessed using a Musculoskeletal Tumor Society (MSTS) score and Toronto Extremity Salvage Score (TESS).ResultsThe mean age of the patients was 17 years (SD 9.1). At a mean follow-up of 70.8 months (SD 50), the mean functional outcomes were 24.2 points (SD 6.3) for MSTS and 81 points (SD 11) for TESS. The mean MSTS and TESS scores were associated with the iliac resection zone (< 0.001). Nine patients (20.9%) had local recurrence. The recurrence was not associated with the zone of iliac resection (p = 0.324). The two-year disease-free survival of the patients was 69.4%. The mean time to graft union was longer in patients with the I4 resection zone (p < 0.001). The complication rate was 34.9%, and nerve palsy (11.6%) was the most common. The rate of surgical complications was not associated with the resection zone.ConclusionReconstruction using tibial strut allograft is an efficient procedure after the resection of the ilium and iliosacral ES. Functional outcomes and complications of iliac ES depend on the resection zone, and inferior outcomes could be generally expected when more segments of the pelvic ring are resected, even if it is reconstructed.Cite this article: Bone Jt Open 2024;5(5):385–393.
Systematic review and meta-analysis of Tuberculosis and COVID-19 Co-infection: Prevalence, fatality, and treatment considerations
Authors: Wang Quan , Cao Yanmin , Liu Xinyu , Fu Yaqun , Zhang Jiawei , Zhang Yeqing , Zhang Lanyue , Wei Xiaolin , Yang Li 
Published: May 2024

Background
Tuberculosis (TB) and COVID-19 co-infection poses a significant global health challenge with increased fatality rates and adverse outcomes. However, the existing evidence on the epidemiology and treatment of TB-COVID co-infection remains limited.

Methods
This updated systematic review aimed to investigate the prevalence, fatality rates, and treatment outcomes of TB-COVID co-infection. A comprehensive search across six electronic databases spanning November 1, 2019, to January 24, 2023, was conducted. The Joanna Briggs Institute Critical Appraisal Checklist assessed risk of bias of included studies, and meta-analysis estimated co-infection fatality rates and relative risk.

Results
From 5,095 studies screened, 17 were included. TB-COVID co-infection prevalence was reported in 38 countries or regions, spanning both high and low TB prevalence areas. Prevalence estimates were approximately 0.06% in West Cape Province, South Africa, and 0.02% in California, USA. Treatment approaches for TB-COVID co-infection displayed minimal evolution since 2021. Converging findings from diverse studies underscored increased hospitalization risks, extended recovery periods, and accelerated mortality compared to single COVID-19 cases. The pooled fatality rate among co-infected patients was 7.1% (95%CI: 4.0% ~ 10.8%), slightly lower than previous estimates. In-hospital co-infected patients faced a mean fatality rate of 11.4% (95%CI: 5.6% ~ 18.8%). The pooled relative risk of in-hospital fatality was 0.8 (95% CI, 0.18–3.68) for TB-COVID patients versus single COVID patients.

Conclusion
TB-COVID co-infection is increasingly prevalent worldwide, with fatality rates gradually declining but remaining higher than COVID-19 alone. This underscores the urgency of continued research to understand and address the challenges posed by TB-COVID co-infection.
Imaging performance of portable and conventional ultrasound imaging technologies for ophthalmic applications
Authors: Thomas Jack O. , To Josiah K. , Vu Anderson N. , Horton David , Dzihic Ermin , Browne Andrew W. 
Published: May 2024

Purpose
The aim of this study was to evaluate the imaging capabilities of Butterfly iQ with conventional ophthalmic (piezoelectric) ultrasound (COU) for ophthalmic imaging.

Methods
Custom phantom molds were designed and imaged with Butterfly iQ and COU to compare spatial resolution capabilities. To evaluate the clinical imaging performance of Butterfly iQ and COU, a survey containing pathological conditions from human subjects, imaged with both Butterfly iQ and COU probes, was given to three retina specialists and graded on image detail, resolution, quality, and diagnostic confidence on a ten-point Likert scale. Kruskal-Wallis analysis was performed for survey responses.

Results
Butterfly iQ and COU had comparable capabilities for imaging small axial and lateral phantom features (down to 0.1 mm) of high and low acoustic reflectivity. One of three retina specialists demonstrated a statistically significant preference for COU related to resolution, detail, and diagnostic confidence, but the remaining graders showed no significant preference for Butterfly iQ or COU across all sample images presented.

Conclusion
The emergence of portable ultrasound probes offers an affordable alternative to COU technologies with comparable qualitative imaging resolution down to 0.1 mm. These findings suggest the value to further study the use of portable ultrasound systems and their utility in routine eye care.
The use of artificial neural networks and decision trees: Implications for health-care research
Authors: Smith Shaina , McConnell Sabine 
Published: May 2024

Abstract
The use of decision trees and artificial neural networks (ANNs) in health-care research is widespread, as they enable health-care providers with the tools they need to make better medical decisions with their patients. ANNs specifically are extremely helpful in predictive research as they can provide investigators with knowledge about future trends and patterns. However, a major downside to ANNs is their lack of interpretability. Understandability of the model is important as it ensures the outcomes are true to the dataset’s original labels and are not impacted by algorithmic bias. In comparison, decision trees map out their entire process before providing the results, which leads to a higher level of trust in the model and the conclusions it supplies the investigators with. This is essential as many historical datasets lack equal and fair representation of all races and sexes, which might directly correlate to a lesser treatment given to females and individuals in minority groups. Here, we review existing work around the differences and connections between ANNs and decision trees with implications for research in health care.
Mesenchymal stem cell-derived exosomal miR-26a induces ferroptosis, suppresses hepatic stellate cell activation, and ameliorates liver fibrosis by modulating SLC7A11
Authors: Cao Ying , Yang Huan , Huang Yan , Lu Jian , Du Hong , Wang Bingying 
Published: May 2024

Abstract
Liver fibrosis is a key contributor to hepatic disease-related mortality. Exosomes derived from mesenchymal stem cells (MSCs) have been revealed to improve liver fibrosis. To explore the effect and mechanism of MSC-derived exosomal miR-26a on liver fibrosis, exosomes were separated from bone marrow-derived MSCs (BMSCs) and used to treat with LX2 cells. The miR-26a level was decreased in BMSC-derived exosomes. Treatment with exosomes isolated from human BMSCs transfected with miR-26a mimics (miR-26a mimic-Exo) decreased the 5-ethynyl-2'-deoxyuridine-positive cell rate, the protein level of α-SMA and collagen I, and the glutathione (GSH) level but enhanced the apoptosis rate and the reactive oxide species (ROS) level in LX2 cells, which were reversed by the treatment of deferoxamine. Mechanically, miR-26a directly bound SLC7A11 mRNA and negatively modulated the level of SLC7A11 in LX2 cells. Overexpression of SLC7A11 reversed the miR-26a mimic-Exo-induced alterations in the level of ROS, Fe2+, malonaldehyde, and GSH in LX2 cells. In vivo, miR-26a mimic-Exo decreased the level of SLC7A11 and attenuated CCL4-induced liver fibrosis. Collectively, miR-26a mimic-Exo induced ferroptosis to alleviate liver fibrosis by regulating SLC7A11, which may provide new strategies for the treatment of liver fibrosis, and even other relevant diseases.
Acoustical analysis and optimization design of the hair dryers
Authors: Che Luming , Lee Hsiao Mun , Lee Heow Pueh 
Published: May 2024

Abstract
The sound qualities and wind speeds of the four commercial hair dryers (Panasonic, Confu, Flyco, and Philips) were investigated through experimental methods in the present study. The sound qualities included loudness, sharpness, roughness, and fluctuation strength. The experimental results showed that the maximum sound pressure level (SPL) of all hair dryers occurred at about 200 Hz except Flyco hair dryer, which occurred at about 400 Hz. The highest loudness and highest sharpness were found when the hair dryers were set to hot mode and cold mode, respectively. No consistent relationship was found between the effect of room space and SPLs of the hair dryers. The Box–Behnken design method was used to design 13 pieces of oval and rectangular nozzles, and their sound levels and wind speeds were measured. Thereafter, these experimental results were used to derive correlation coefficients between the hair dryer nozzle area, aspect ratio, nozzle length, loudness, and wind speed using the Anova analysis method. Finally, an oval nozzle and a rectangular nozzle with an area of 0.0005 m

2

{}^{2}

, an aspect ratio of 1, and nozzle lengths of 0.052 and 0.055 m, respectively, were designed and were tested. These nozzles managed to reduce the sound loudness by 15 and 9.6%, respectively, while maintaining the same level of wind speed.
Synergistic effect of ZnO nanocomposite of Dodonea viscosa for corrosion inhibition in saline media
Authors: Alghamdi Maha D. 
Published: May 2024

Abstract

Dodonea viscosa-zinc oxide (DV-ZnO) nanocomposite was synthesized and characterized using Fourier transform infrared (FTIR), thermal gravimetric method (TGA), X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy dispersive X-ray spectroscopy (EDS). The most abundant compounds in the plant extract were explored using gas chromatography-mass spectrometry (GC-MS). FTIR indicated the existence of the different functional groups, XRD showed that the nanocomposite has the hexagonal wurtzite shape of ZnO nanoparticles, SEM-EDS showed a size of 50 nm, and elemental analysis depicts the existence of the different elements in the extract, which confirms, along with TGA results, the formation of DV-ZnO nanocomposite. The nanocomposite synergistic effect was examined for anticorrosion capabilities using gravimetric, electrochemical, and surface analysis methods. Both the plant extract and the nanocomposite exhibited corrosion inhibition abilities. However, the incorporation of the plant extract with ZnO increased the inhibition efficiency by 20 %. Weight loss and electrochemical methods concluded an inhibition efficiency of 80 % for DV-ZnO nanocomposite. The inhibition of the nanocomposite is due to the adsorption of the inhibitor on the carbon steel surface, which was verified using X-ray photoelectron spectroscopy and scanning electron microscopy (SEM). The adsorption was found to follow both Langmuir and Temkin isotherms. Surface examination using atomic force microscopy (AFM) found that the carbon steel surface roughness was decreased from the sample submerged in an uninhibited medium (Sa = 121.20 nm) when adding DV-ZnO nanocomposite (Sa = 22.95 nm) and DV plant extract inhibitor (Sa = 54.73 nm).
The potential of student as partners approaches for humanitarian developments
Authors: Lowe Tom , Moxey Maria 
Published: May 2024

This article explores the potential for students-as-partners models developed in the scholarship of teaching and learning and educational development fields to be expanded to new agendas such as humanitarian developments and other agendas related to the so-called civic university. There is a growing appetite for students and staff to work in partnership due to the mutual benefits for both parties (Mapstone et al., 2017), yet the majority of the published works on students as partners is almost exclusively reporting upon partnership activities relating to curriculum and wider student experience developments in higher education. This paper explores the literature on best practice for working with students as partners in order to create new recommendations for how the students-as-partners model can be applied successfully for community and humanitarian development projects, rather than curricular, teaching, or research projects By drawing on literature from student voice, student engagement in quality assurance, and co-design, this paper will highlight the great potential of student-staff partnerships for addressing other development agendas globally.
Reproductive Ageing: Inflammation, immune cells, and cellular senescence in the aging ovary
Authors: Isola José V V , Hense Jessica D , Osório César A P , Biswas Subhasri , Alberola-Ila José , Ocañas Sarah R , Schneider Augusto , Stout Michael B 
Published: May 2024

In brief
Recent reports suggest a relationship between ovarian inflammation and functional declines, although it remains unresolved if ovarian inflammation is the cause or consequence of ovarian aging. In this review, we compile the available literature in this area and point to several current knowledge gaps that should be addressed through future studies.

Abstract
Ovarian aging results in reduced fertility, disrupted endocrine signaling, and an increased burden of chronic diseases. The factors contributing to the natural decline of ovarian follicles throughout reproductive life are not fully understood. Nevertheless, local inflammation may play an important role in driving ovarian aging. Inflammation progressively rises in aged ovaries during the reproductive window, potentially affecting fertility. In addition to inflammatory markers, recent studies show an accumulation of specific immune cell populations in aging ovaries, particularly lymphocytes. Other hallmarks of the aging ovary include the formation and accumulation of multinucleated giant cells, increased collagen deposition, and increased markers of cellular senescence. Collectively, these changes significantly impact the quantity and quality of ovarian follicles and oocytes. This review explores recent literature on the alterations associated with inflammation, fibrosis, cell senescence, and the accumulation of immune cells in the aging ovary.
КОМПЛЕКСНЕ ДОСЛІДЖЕННЯ НОВИХ АДСОРБЦІЙНИХ МАТЕРІАЛІВ
Authors: Якименко Ірина К. , Солодовнік Тетяна В. 
Published: May 2024

У роботі було отримано та проведено комплексне порівняльне дослідження адсорбентів, отриманих поєднанням кокосового вугілля та коагулянтів на основі солей алюмінію (Al2(SO4)3 та AlCl3) і флокулянтів (альгінату натрію та хітозану), для видалення іонів феруму та мангану з модельних розчинів. Адсорбенти, на основі кокосового вугілля та флокулянтів, отримували методом просочування з подальшим висушуванням за температури 50 °C впродовж 6 годин (КАУ+Х1, КАУ+Х2 та КАУ+АН). Одержання адсорбентів на основі кокосового вугілля та коагулянтів проводили додаванням солей алюмінію до водного розчину карбаміду за температури 95°C з інтенсивним переміщуванням впродовж 30 хв з кокосовим вугіллям (КАУ+ AlC КАУ+AlS). Отримані адсорбенти були перевірені на ефективність вилучення іонів феруму та мангану з водних систем, та за результатами дослідження кінетики адсорбції наведено їх порівняльні характеристики. Встановлено, що найбільш ефективним для видалення іонів феруму та мангану в порівнянні з кокосовим вугіллям є адсорбент на основі кокосового вугілля та флокулянту альгінату натрію (КАУ+АН). Оптимальна тривалість контактування даного адсорбенту з адсорбатом складає 60 хв; за цей час досягається ефективний ступінь очищення для іонів феруму – 82.5 %, іонів мангану – 84.65 %, що на 7–15 % для іонів заліза та на 18–20 % для іонів мангану більше в порівнянні з кокосовим вугіллям КАУ та іншими досліджуваними адсорбентами. Встановлено оптимальну дозу адсорбенту КАУ+АН, що складає 5 г/дм3. Наведено переваги даного адсорбенту, який характеризується високим ступенем вилучення іонів заліза та мангану в статичних умовах і може бути рекомендованим для очищення водних розчинів та подальшого дослідження в динамічних умовах.
The Geometric Construction of Hexagonal Apses in Mediaeval Hungary
Authors: Budaházi Fanni , Halmos Balázs 
Published: May 2024

Geometric construction in Gothic architecture has been a popular subject of research for centuries. The use and extent of quadrature and triangulation grids has long been debated, as the few architectural drawings that survived from the era do not indicate the construction process. Modern surveying methods, however, allow us to inspect the exact geometry of a building with all its irregularities – in the case of this article we use 3D point clouds created by laser scanning, from which accurate measurements can be taken.In our study we analyse four churches from mediaeval Hungary: the Franciscan church of Szeged-Alsóváros, the fortified church of Cincu (RO, Nagysink/Großschenk), the Franciscan church of GyöngyösAlsóváros and the fortified church of Mediaș (RO, Medgyes/Mediasch). Each of these are built with elongated choirs and approximately hexagonal apses. We explore the possible construction systems of these buildings and compare them to each other. We aim to present the similarities and differences between them and to offer likely explanations of their irregularities. Moreover, we propose the significance of construction circles used for creating a triangulation grid.
Valores y Conductas Académicas Deshonestas en Estudiantes Universitarios
Authors: Rodriguez Santos Federico Osorto , Rodriguez Jonatan 
Published: May 2024

Objetivo: El estudio analiza los valores (TMV) que se relacionan con las conductas académicas deshonestas en estudiantes universitarios. Método: Con un enfoque cuantitativo y un diseño no experimental transversal, de alcance relacional-correlacional, se aplicó un instrumento en línea que constaba de dos partes: la primera es el PVQ (Portrait Values ​​​​Questionnaire) de Schwartz (2012) . La segunda parte, fueron diez artículos diseñados para evaluar cinco conductas académicas deshonestas. Se contó con una muestra de 301 estudiantes de universidades públicas y privadas, nacionales (Honduras) e internacionales. Conclusiones: Según los hallazgos, no existe una relación significativa entre los valores personales desde la teoría de Schwartz con las conductas académicas deshonestas. Se ha encontrado evaluación débil positiva entre los Recursos de Poder y Poder-dominación con las cinco conductas académicas deshonestas. El Hedonismo presenta limitación débil positiva con la conducta Duplicar trabajos. Recomendación: Se sugiere continuar con la búsqueda de correlaciones entre los TMV y otros comportamientos en el contexto hondureño.
Acceso abierto en Argentina: una propuesta para el monitoreo de las publicaciones científicas con OpenAlex
Authors: Unzurrunzaga Carolina , Monti Carolina , Zalba Gastón , Alperin Juan Pablo 
Published: May 2024

En este estudio se propone una metodología utilizando OpenAlex (OA) para monitorear el acceso abierto (AA) a las publicaciones científicas para el caso de Argentina, país donde rige el mandato de autoarchivo -Ley 26.899 (2013)-. Se conformó una muestra con 167.240 artículos de investigadores del Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) que se analizaron con técnicas estadísticas. Se estimó que OA puede representar entre 85-93% de los autores para todas las disciplinas, excepto Ciencias Sociales y Humanidades, donde solo alcanza al 47%. Se calculó que 41% de los artículos publicados entre 1953-2021 incluidos en la fuente están en AA, porcentaje que sube a 46% al considerar exclusivamente el periodo post ley (2014-2021). En ambos periodos es la vía dorada la que representa mayor proporción. Al comparar periodos iguales post y pre ley, se observó que la tendencia en alza de la vía dorada era preexistente a la legislación y la disponibilidad de artículos cerrados en repositorios aumentó un 5% a lo que se estima en base a tendencias existentes. Se concluye que si bien la vía verde ha tenido una evolución positiva, ha sido la publicación en revistas doradas lo que ha impulsado más rápidamente el acceso a la producción argentina. Asimismo, que la metodología basada en OA, piloteada aquí por primera vez, es viable para monitorear el AA en Argentina ya que arroja porcentajes similares a otros estudios nacionales e internacionales.