bluuebunny/crossref_metadata_2025_split huggingface dataset:
Profile of adult -onset epilepsy in Zagazig university hospitals
Authors: Nageeb Rania S. , Ismail Adaham Mahmoud Mohamad , Youssef Sawsan Abd El Aziz , Mohamed Eman Atef 
Published: May 2024

Abstract
Background
Epilepsy has many neurobiological consequences. This study aimed to identify the profile of adult patients with new onset epilepsy in our university hospitals as regarding clinical picture, etiology, cerebral imaging and electroencephalogram (EEG) correlation, comorbidities, management, drug therapy and seizure severity and quality of life. We recruited one hundred patients with adult onset epilepsy, and we assessed them clinically, radiologically, and electrophysiologically. We performed Liverpool Seizure Severity Scale (LSSS) to assess seizure severity and the Quality of Life In Epilepsy-10 Questionnaire (QOLIE-10) to assess quality of life of adult patients with new onset epilepsy.

Results
Fifty-seven percent of the studied patients were males, and 43.0% were females with mean (± SD) of age was 52.83 (± 17.33), 13.0% of the studied patients had positive family history of epilepsy. 32.0% had focal epilepsy, and 68.0% had generalized epilepsy, 53% of patients had uncontrolled seizures, 49% of patients were on monotherapy, and 51.0% were on polytherapy. The mean (± SD) seizure frequency per month in the studied patients was 4.0 (± 3.15). Imaging abnormalities were found in 88% of studied patients. 43% of the studied patients had abnormal EEG. Post-traumatic epilepsy, focal cortical dysplasia and mesial temporal sclerosis were statistically significant higher in male patients than female patients. Arteriovenous malformations were significantly higher in females. Middle-aged adults’ group had hypertension more than other age groups, older adult age group had atrial fibrillation, coronary heart disease, diabetes mellitus and dyslipidemia more than other age groups. Young adults had migraine more than other age groups. Post-stroke epilepsy was higher in older adult and middle-aged adult groups more than young adult age group. Intracranial neoplasms were higher in older adult age group than other age groups. Patients with moderate, severe, and very severe LSSS score had significantly more frequent uncontrolled seizures, abnormal EEG and higher rate of polytherapy as compared to those with mild LSSS score. Patients with impaired quality of life had more seizure frequency, less seizure control, higher seizure severity, more EEG abnormalities and were mostly treated by AEDs polytherapy than those with average life quality.

Conclusions
Levetiracetam was the most preferred drug for treating patients with adult-onset epilepsy (40%), whether used as monotherapy or in combination with other drugs. Seizure severity, and seizure frequency per month strongly impaired patients’ quality of life.
Investigating white matter changes in auditory cortex and association fibres related to speech processing in noise-induced hearing loss: a diffusion tensor imaging study
Authors: Zolkefley Mohd Khairul Izamil , Abdull Norhidayah , Shamsuddin Perisamy Rajeev , Mustapha Muzaimi , Adam Daud , Muhamad Noordin Muhamad Ariff 
Published: May 2024

Abstract
Background
This study explores the impact of noise-induced hearing loss (NIHL) on the microstructural integrity of white matter tracts in the brain, focusing on areas involved in speech processing. While the primary impact of hearing loss occurs in the inner ear, these changes can extend to the central auditory pathways and have broader effects on brain function. Our research aimed to uncover the neural mechanisms underlying hearing loss-related deficits in speech perception and cognition among NIHL patients.

Methods
The study included two groups: nine bilateral NIHL patients and nine individuals with normal hearing. Advanced diffusion tensor imaging techniques were employed to assess changes in the white matter tracts. Regions of interest (ROIs), including the auditory cortex, cingulum, arcuate fasciculus, and longitudinal fasciculus, were examined. Fractional anisotropy (FA) values from these ROIs were extracted for analysis.

Results
Our findings indicated significant reductions in FA values in NIHL patients, particularly in the left cingulum, right cingulum, and left inferior longitudinal fasciculus. Notably, no significant changes were observed in the auditory cortex, arcuate fasciculus, superior longitudinal fasciculus, middle longitudinal fasciculus, and right inferior longitudinal fasciculus, suggesting differential impacts of NIHL on various white matter tracts.

Conclusions
The study's findings highlight the importance of considering association fibres related to speech processing in treating NIHL, as the broader neural network beyond primary auditory structures is significantly impacted. This research contributes to understanding the neurological impact of NIHL and underscores the need for comprehensive approaches in addressing this condition.
Participatory action research to develop and implement multicomponent, multilevel strategies for implementing colorectal cancer screening interventions in American Indian communities in New Mexico
Authors: Adsul Prajakta , English Kevin , Jim Cheyenne , Pankratz V. Shane , Edwardson Nicholas , Sheche Judith , Rodman Joseph , Charlie Jimmie , Pagett John , Trujillo Jonathan , Grisel-Cambridge Jillian , Mora Steven , Yepa Kaitlyn L. , Mishra Shiraz I. 
Published: May 2024

Abstract
Background
Despite the effectiveness of colorectal cancer (CRC) screening, American Indians (AIs) have low screening rates in the US. Many AIs receive care at Indian Health Services, Tribal, and Urban Indian (I/T/U) healthcare facilities, where published evidence regarding the implementation of CRC screening interventions is lacking. To address this gap, the University of New Mexico Comprehensive Cancer Center and the Albuquerque Area Southwest Tribal Epidemiology Center collaborated with two tribally-operated healthcare facilities in New Mexico with the goal of improving CRC screening rates among New Mexico’s AI communities.

Methods
Guided by the principles of Community Based Participatory Research, we engaged providers from the two tribal healthcare facilities and tribal community members through focus group (two focus groups with providers (n = 15) and four focus group and listening sessions with community members (n = 65)), to elicit perspectives on the feasibility and appropriateness of implementing The Guide to Community Preventive Services (The Community Guide) recommended evidence-based interventions (EBIs) and strategies for increasing CRC screening. Within each tribal healthcare facility, we engaged a Multisector Action Team (MAT) that participated in an implementation survey to document the extent to which their healthcare facilities were implementing EBIs and strategies, and an organizational readiness survey that queried whether their healthcare facilities could implement additional strategies to improve uptake of CRC screening.

Results
The Community Guide recommended EBIs and strategies that received the most support as feasible and appropriate from community members included: one-on-one education from providers, reminders, small media, and interventions that reduced structural barriers. From the providers’ perspective, feasible and acceptable strategies included one-on-one education, patient and provider reminders, and provider assessment and feedback. Universally, providers mentioned the need for patient navigators who could provide culturally appropriate education about CRC and assist with transportation, and improved support for coordinating clinical follow-up after screening. The readiness survey highlighted overall readiness of the tribal facility, while the implementation survey highlighted that few strategies were being implemented.

Conclusions
Findings from this study contribute to the limited literature around implementation research at tribal healthcare facilities and informed the selection of specific implementation strategies to promote the uptake of CRC screening in AI communities.
Meta-analysis on the global prevalence of Arcobacter in food-producing animals and humans
Authors: Zhang Penghang , Liu Yuzhu , Fu Mengjiao , Wang Bing , Ding Shuangyang , Ma Xiaochen , Zhang Xiaoai , Shen Zhangqi 
Published: May 2024

AbstractThe genus Arcobacter has been associated with illnesses in both animals and humans, where Arcobacter butzleri, Arcobacter cryaerophilus, and Arcobacter skirrowii have been linked to numerous cases of gastrointestinal diseases in humans. While isolated instances of Arcobacter infection have been reported in certain areas, comprehensive data reflecting the global impact of Arcobacter infection are lacking. This meta-analysis was conducted with the objective of assessing the aggregated prevalence of Arcobacter across diverse sources on a global scale. We conducted a thorough literature search of the Scopus, PubMed, and ScienceDirect databases to identify studies published from 1992 to 2022 on Arcobacter prevalence in humans and food-producing animals. We utilized multilevel random effects meta-analysis models to gauge the average occurrence of Arcobacter and to examine various factors that could influence incidence outcomes. Seventy-five articles were included in the meta-analysis. The pooled prevalence of Arcobacter spp. from different sources was 21.9% (95% CI: 18.0%–26.1%), and the mean prevalence of A. butzleri, A. cryaerophilus, and A. skirrowii was 15.1%, 2.8%, and 0.1%, respectively. Arcobacter spp. had the lowest prevalence in humans (1.8%; 95% CI: 0.7%–3.3%) and the highest in broilers (38.8%; 95% CI: 28.0%–50.1%). Among animal-derived food products, carcasses or carcass parts exhibited the highest Arcobacter spp. prevalence of 28.6% (28.6%; 95% CI: 23.7%–33.7%). This meta-analysis revealed that A. butzleri is the most prevalent Arcobacter species worldwide, with broilers, as well as seafood, being the primary hosts of Arcobacter spp. We recommend developing appropriate prevention strategies and conducting further local in-depth studies to establish the actual epidemiological burden of Arcobacter.
Exploring the differential effects of psychological resilience and social support in mitigating post-traumatic psychiatric symptoms: real-world network analysis of front-line rescuers
Authors: Cheng Peng , Wang Lirong , Zhou Ying , Ma Wenjing , Li Weihui 
Published: May 2024

BackgroundAlthough both psychological resilience and social support are widely believed to be effective in alleviating post-traumatic psychiatric symptoms in individuals with traumatic events, there has been a lack of comparative analysis of their intervention effects on different post-traumatic psychiatric symptoms. Furthermore, previous studies have mostly failed to control for potential confounding effects caused by different traumatic events.AimsWe used the novel network analysis approach to examine the differential moderating effects of psychological resilience and social support on post-traumatic psychiatric symptoms, controlling for the confounding effects of traumatic events.MethodWe recruited 264 front-line rescuers who experienced the same traumatic event. Quantified edge weights and bridge expected influence (BEI) were applied to compare the alleviating effects of psychological resilience and social support.ResultsOur study revealed distinct correlations in a sample of front-line rescuers: social support negatively correlates more with psychosomatic symptoms, notably fatigue in depressive networks and sleep disturbance in post-traumatic stress disorder (PTSD) networks, whereas psychological resilience shows fewer such correlations. Quantitative analysis using BEI indicated that psychological resilience more effectively suppresses depressive and anxiety symptom networks, whereas social support more significantly inhibits PTSD symptom networks.ConclusionsThe current study represents the first attempt to examine the differential effects of psychological resilience and social support on post-traumatic outcomes in real-world emergency rescuers, controlling for the confounding effect of traumatic events. Our results can act as the theoretical reference for future precise and efficient post-trauma psychological interventions.
Oscillatory control of embryonic development
Authors: Chandel Angad Singh , Keseroglu Kemal , Özbudak Ertuğrul M. 
Published: May 2024

ABSTRACT
Proper embryonic development depends on the timely progression of a genetic program. One of the key mechanisms for achieving precise control of developmental timing is to use gene expression oscillations. In this Review, we examine how gene expression oscillations encode temporal information during vertebrate embryonic development by discussing the gene expression oscillations occurring during somitogenesis, neurogenesis, myogenesis and pancreas development. These oscillations play important but varied physiological functions in different contexts. Oscillations control the period of somite formation during somitogenesis, whereas they regulate the proliferation-to-differentiation switch of stem cells and progenitor cells during neurogenesis, myogenesis and pancreas development. We describe the similarities and differences of the expression pattern in space (i.e. whether oscillations are synchronous or asynchronous across neighboring cells) and in time (i.e. different time scales) of mammalian Hes/zebrafish Her genes and their targets in different tissues. We further summarize experimental evidence for the functional role of their oscillations. Finally, we discuss the outstanding questions for future research.
Target Firm Advertising and Firm Value
Authors: Fich Eliezer M. , Starks Laura T. , Tran Anh L. 
Published: May 2024

Consistent with hypotheses underlying firm advertising, we find that targets with pretakeover advertising obtain higher premiums, whereas their acquirers earn lower announcement returns. These economically significant effects suggest that through advertising, targets increase their profile and negotiating power. Further, targets that advertise are more likely to initiate their takeovers, attract multiple bidders, receive enhanced bids, capture more merger rents, and even in failed acquisitions, experience a 1% permanent revaluation. The latter result differentiates between information asymmetry and behavioral explanations for the target advertising. Overall, the results support the hypothesis that management advertises to transmit information to investors and potential acquirers. This paper was accepted by Victoria Ivashina, finance. Funding: A. L. Tran acknowledges financial support from the Mergers and Acquisitions Research Centre at Bayes Business School. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.01534 .
O rap de autoria indígena: descolonizando currículos e saberes nas aulas de língua portuguesa
Authors: Fraguas Marcela Martins de Melo 
Published: May 2024

No presente artigo, analisa-se o rap “Demarcação Já – Terra Ar Mar”, do rapper indígena Owerá, com participação do rapper Criolo. Pretende-se que as discussões apresentadas contribuam para o ensino crítico, reflexivo e descolonial de língua portuguesa. O videoclipe do rap também foi observado, de modo a destacar a importância de que outras formas de produção de sentido, não restritas ao emprego da norma padrão, verbal e escrita, socialmente valorizada, sejam consideradas. Adotou-se, além disso, a perspectiva da interculturalidade crítica, como forma de integração de sujeitos historicamente subalternizados nos currículos. Embasam teoricamente este estudo, as considerações acerca de modernidade/colonialidade trazidas por Mignolo (2017), Quijano (2005), Walsh (2009, 2013), de autoria indígena, por Portela e Nogueira (2016), do movimento cultural hip-hop, por Souza (2011), da identificação com o rap por grupos indígenas, por Nascimento (2014), entre outros. Os resultados evidenciam a relevância da inclusão das produções dos próprios autores nos currículos. Considera-se, portanto, que temas, gêneros textuais e autores, frequentemente, marginalizados devem ser postos em relevo, em prol de uma formação voltada para a descolonização de saberes e para a justiça social.

Palavras-chave: Ensino de língua portuguesa. Descolonialidade. Autoria indígena. Rap.
PATIENT-SPECIFIC TKA TWO-YEAR OUTCOME STUDY: VELYS VERSUS BRAINLAB VELYS ROBOTIC-ASSISTED SOLUTION (VRAS) VERSUS BRAINLAB 3 TKA. TWO-YEAR OUTCOME DATA STUDY
Authors: Clatworthy Mark 
Published: May 2024

IntroductionThe first VRAS TKA was performed in New Zealand in November 2020 using a Patient Specific Balanced Technique whereby VRAS enables very accurate collection of the bony anatomy and soft tissue envelope of the knee to plan and execute the optimal positioning for a balanced TKAMethodThe first 45 VRAS patients with idiopathic osteoarthritis of the knee was compared with 45 sequential patients who underwent the same TKA surgical technique using Brainlab 3 which the author has used exclusively in over 1500 patients. One and two year outcome data will be presentedResultsOne year outcome dataVely Brainlab Significance Oxford 43.4 40.5 P=0.01 WOMAC 8.4 14.1P=0.02 Forgotten Joint Score 72.2 58.3 P=0.01 KOOS ADL91.3 85.8 P=0.04 Normal 83.3 74.2P =0.048 Activity Pain 8.6 18.4 P=0.009 ROM 127 124 P=0.01 Patient Satisfaction 98% 95% P=0.62 Operation again 100% 91% P=0.055 The two year data will be available for the ASM Conclusion: The one year outcome data shows a significantly better Oxford, WOMAC, Forgotten Joint score, KOOS ADL, Normal score and ROM scores and the activity pain is less compared to the authors extensive experience with Brainlab 3.
TIME TO SURGERY FOR NECK OF FEMUR FRACTURES IN SOUTHLAND FOR PATIENTS PRESENTING DIRECTLY TO A REFERRAL HOSPITAL VERSUS TRANSFERRAL FROM PERIPHERAL HOSPITAL: A MATCHED COHORT STUDY
Authors: Bolam S. M. , Matheson N. , Douglas M. , Anderson K. , Weggerty S. , Londahl M. , Gwynne-Jones D. , Navarre P. 
Published: May 2024

IntroductionThe Te Whatu Ora Southern catchment area covers the largest geographical region in New Zealand (over 62,000 km2) creating logistical challenges in providing timely access to emergency neck of femur (NOF) fracture surgery. Current Australian and New Zealand guidelines recommend that NoF surgery be performed within 48 hours of presentation. The purpose of this study was to compare the outcomes for patients with NoF fractures who present directly to a referral hospital (Southland Hospital) compared to those are transferred from rural peripheral centres.MethodsA retrospective cohort study identified 79 patients with NoF who were transferred from rural peripheral centres to a referral hospital for operative management between January 2011 to December 2020. This cohort was matched 1:1 by age and sex to patients with NoF who presently directly to the referral hospital over the same period. The primary outcome was to compare time to surgery between the groups and secondary outcomes were to compare length of hospital stay, complication rates and mortality rates at 30-days and 1-year.ResultsThe mean delay in transfer time from peripheral centres was 11.5 ± 6.4 h. The mean time to surgery was higher, but not significantly different (p=0.155), for patients transferred from peripheral centres compared to patients presenting directly to the referral hospital (30.7 ± 16.5 h vs. 26.8 ± 17.2 h, respectively). However, rates of surgery within 48 h were similar between the patients transferred from peripheral centres and patients presenting directly to the referral hospital (8.8% vs 7.6%, p>0.999). There were no significant differences in complication rates, length of stay or 30-day or 1-year mortality between the groups.Discussion and ConclusionSignificant delays in transfer from peripheral centres to the referral hospital were identified, averaging 11.5 h. There was a strong trend towards increased time to surgery for patients transferred from peripheral centres. Early transfer of patients with NoF to a referral hospital should continue to be made a high priority.
OUTCOMES FOLLOWING A TOTAL FEMORAL PLATING TECHNIQUE FOR MANAGEMENT OF PERIPROSTHETIC FRACTURES AROUND STABLE HIP AND KNEE IMPLANTS
Authors: Sandiford Nemandra A. , Atkinson Brad , Trompeter Alex , Kendoff Daniel 
Published: May 2024

IntroductionManagement of Vancouver type B1 and C periprosthetic fractures in elderly patients requires fixation and an aim for early mobilisation but many techniques restrict weightbearing due to re-fracture risk. We present the clinical and radiographic outcomes of our technique of total femoral plating (TFP) to allow early weightbearing whilst reducing risk of re-fracture.MethodsA single-centre retrospective cohort study was performed including twenty-two patients treated with TFP for fracture around either hip or knee replacements between May 2014 and December 2017. Follow-up data was compared at 6, 12 and 24 months.Primary outcomes were functional scores (Oxford Hip or Knee score (OHS/OKS)), Quality of Life (EQ-5D) and satisfaction at final follow-up (Visual Analogue Score (VAS)). Secondary outcomes were radiographic fracture union and complications.ResultsMean OHS and OKS was 50.25, EQ-5D score was >4 for all modalities, VAS was 64.4/100. Radiographs demonstrated bony union in 58% at 3 months and 76% at 6 months. We identified no case of re-fracture however non-union occurred in 4 patients. No other operative complications were identified.ConclusionThese results suggest that TFP may be a safe, viable option for management of periprosthetic fractures around stable implants allowing the benefit of early weightbearing, satisfactory outcomes and low re-fracture risk.
Feasibility and safety of in-bed cycling/stepping in critically ill patients: A study protocol for a pilot randomized controlled clinical trial
Authors: Wi Soohyun , Shin Hyung-Ik , Hyun Sung Eun , Sung Kwan-Sik , Lee Woo Hyung 
Published: May 2024

Background
Intensive care unit (ICU)-acquired weakness (ICU-AW) is one of the most common complications of post-ICU syndrome. It is the leading cause of gait disturbance, decreased activities of daily living, and poor health-related quality of life. The early rehabilitation of critically ill patients can reduce the ICU-AW. We designed a protocol to investigate the feasibility and safety of conventional rehabilitation with additional in-bed cycling/stepping in critically ill patients.

Methods
The study is designed as a single-center, single-blind, pilot, randomized, parallel-group study. After the screening, participants are randomly allocated to two groups, stratified by mechanical ventilation status. The intervention group will be provided with exercises of in-bed cycling/stepping according to the level of consciousness, motor power, and function in addition to conventional rehabilitation. In contrast, the control group will be provided with only conventional rehabilitation. The length of intervention is from ICU admission to discharge, and interventions will be conducted for 20 minutes, a maximum of three sessions per day.

Results
The outcomes are the number and percentage of completed in-bed cycling/stepping sessions, the duration and percentage of in-bed cycling/stepping sessions, and the number of cessations of in-bed cycling/stepping sessions, the interval from ICU admission to the first session of in-bed cycling/stepping, the number and percentage of completed conventional rehabilitation sessions, the duration and percentage of conventional rehabilitation sessions, the number of cessations of conventional rehabilitation sessions, the number of adverse events, level of consciousness, functional mobility, muscle strength, activities of daily living, and quality of life.

Discussion
This study is a pilot clinical trial to investigate the feasibility and safety of conventional rehabilitation with additional in-bed cycling/stepping in critically ill patients. If the expected results are achieved in this study, the methods of ICU rehabilitation will be enriched.

Trial registration
clinicialtrials.gov, Clinical Trials Registration #NCT05868070.