bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improvement of the oxidative stability of edible oils through enzymatic esterification with hydroxytyrosol‐rich extract
Authors: Fotiadou Renia , Vougiouklaki Despina , Houhoula Dimitra , Stamatis Haralambos 
Published: May 2024

AbstractOxidative degradation is a common issue of commercial edible oils that results in rancidity, downgrading the organoleptic characteristics of food matrices. The aim of this study was the enzymatic modification of common vegetable oils (pomace olive and sunflower oil) with polyphenolic extract to prepare functional oils enriched with bioactive phenolipids. Under that scope, an agro‐industrial effluent, olive mill wastewater, was used as source to recover phenolic compounds. The recovery of hydroxytyrosol and tyrosol reached up to 81.2% ± 0.3% and 98.3% ± 0.2%, respectively. Further, immobilized lipase was used to catalyze the one‐step acylation of these phenolic antioxidants into the oils with the aim of enhancing their stability under accelerated oxidation conditions. The optimum parameters of the bioconversion were found to be 0.1% (w/w) immobilized lipase, 24h of incubation at 50°C under orbital shaking reaching high conversion yields for both phenolic compounds (≥94%). The results also highlighted that the extract‐modified oils presented notable thermooxidative stability at 60°C for 28 days compared to the control and synthetic antioxidant‐enriched oils, as demonstrated by several analytical (conjugated dienes, thiobarbituric reactive substances), chromatographic (solid‐phase microextraction gas chromatography/mass spectroscopy), and spectroscopic (fluorescence, attenuated total reflectance) techniques, giving new insights regarding the preservation of edible oils.Practical Application: Htyr has recently gained much attention as an active ingredient of food matrices for industrial applications due to its high antioxidant/antiradical activity. A major drawback of Htyr exploitation is the high market price and its solubility. Meanwhile, several edible oils are prone to autooxidation during transport, stock management, and household storage. The proposed one‐step biocatalytic process aims to enhance the lipophilicity and bioactivity of Htyr in bulk oil systems, making the use of this potent antioxidant compound feasible. This approach shows promise in extending the shelf life of common oils and highlights the advantages of by‐product management. Moreover, these functional oils can be applied for the preparation of sauces, bakery products, food supplements, and so on, as the bioactive ingredients that are present in them can delay the oxidative cascade reactions and, thus, the spoilage of the products, whereas the whole process meets the requirements of circular economy and green chemistry.
Saving face: Leveraging artificial intelligence‐based negative feedback to enhance employee job performance
Authors: Pei Jialiang , Wang Hongli , Peng Qiuping , Liu Shanshi 
Published: May 2024

AbstractNegative performance feedback is vital for stimulating employees to enhance their performance despite resulting in stress and adverse work outcomes. Fortunately, artificial intelligence (AI)‐enabled automated agents have gradually assumed certain functions led by human leaders, such as providing feedback. Drawing from regulatory focus theory, we propose that AI‐based feedback systems can serve as a “remediation” tool, effectively mitigating employees' apprehensions about receiving negative feedback. In two studies, we found that for employees who fear losing face, AI‐based negative feedback motivates promotion‐focused cognition—motivation to learn—representing a learning mechanism to promote job performance and impedes their prevention‐focused cognition—interpersonal rumination—reducing the depletion needed for job performance. These findings present novel perspectives on using AI in performance feedback.
The association between enteral nutrition with survival of critical patients with COVID‐19
Authors: Gholamalizadeh Maryam , Salimi Zahra , Mobarakeh Khadijeh Abbasi , Mahmoudi Zahra , Tajadod Shirin , Mousavi Mele Mahdi , Alami Farkhondeh , Bahar Bojlul , Doaei Saeid , Khoshdooz Sara , Rahvar Masoume , Gholami Somayeh , Pourtaleb Masoume 
Published: May 2024

AbstractBackgroundCoronavirus disease 2019 (COVID‐19) results in several complications and mortality in intensive care unit (ICU) patients. Limited studies have investigated the effect of enteral nutrition (EN) on the survival of COVID‐19 patients in the ICU. The aim of this study was to investigate the association of EN with biochemical and pathological indices associated with mortality in ICU patients with COVID‐19.MethodsThis case–control study was conducted on 240 patients with COVID‐19 hospitalized in the ICU including 120 eventual nonsurvived as the cases and 120 survived patients as the controls. All of the patients received EN as a high protein high volume or standard formula. Data on general information, anthropometric measurements, and the results of lab tests were collected.ResultsThe recovered patients received significantly more high protein (60.8% vs. 39.6%, p = .004) and high volume (61.6% vs. 42.3%, p = .005) formula compared to the nonsurvived group. Mortality was inversely associated with high volume (odds ratio [OR]: 0.45 confidence interval [CI]95%, p = .008) and high protein (OR: 0.42 CI95%, p = .003) formula. The results remained significant after adjusting for age and sex. Further adjustment for underlying diseases, smoking, body mass index, and the acute physiology and chronic health evaluation II (APACHE II) score did not change the results.ConclusionThe findings of the study showed that there was a significant inverse association between mortality and high volume and high protein formula in patients with COVID‐19. Further investigation is warranted.
Does financial stability communication affect financial asset prices? Evidence from the Bank of England's communication experiment
Authors: Jbir Hamdi 
Published: May 2024

AbstractThis paper examines the Bank of England's (BoE) communication on financial stability between 2013 and 2018. We apply an event study to determine the communication effect on financial institutions' stock market returns. We find that the BoE's announcements generate negative average abnormal returns for non‐banking and banking systems, including the Global Systemically Important Banks. The same effect emerges when we consider the communication's tone. Furthermore, we construct a macroprudential decision communication index and show that the negative impact of the BoE's tone is significant only when the decision communication index value is above average. Moreover, we find evidence that negative abnormal returns tend to appear after the Brexit referendum, while we find positive abnormal returns before that date. Besides, we do not identify a noticeable effect related to communication practices.
Investigating the healthcare‐seeking behaviors of mobile phone users to improve cervical cancer screening in rural Uganda
Authors: Mwandacha Nelly , Dau Hallie , AboMoslim Maryam , Naguti Priscilla , Sheehan Mia , Booth Amy , Smith Laurie , Orem Jackson , Ogilvie Gina , Nakisige Carolyn 
Published: May 2024

AbstractObjectiveCervical cancer is the leading cause of cancer in low‐ and middle‐income countries, despite being preventable. Uganda, which lacks an effective screening program, has one of the highest global cervical cancer incidence rates. Mobile health (mHealth) technology has the potential to improve healthcare‐seeking behaviors and access. The present study describes the connection between mobile phone access and healthcare‐seeking behaviors in rural Uganda.MethodsWomen were eligible for this cross‐sectional study if they had no prior screening or treatment for cervical cancer in the past 5 years, were aged 30 to 49 years old, and were residents of the South Busoga Forest reserve. Survey data was analyzed using descriptive statistics and chi‐square tests.ResultsOf the 1434 participants included in the analysis, 91.4% reported having access to a mobile phone. Most respondents were aged 30–40 years, had a partner, had ≤primary education, and were farmers. Participants with mobile phone access were significantly more likely to report attending a healthcare outreach visit (access = 87.3%, no access = 72.6%, P < 0.001) or visiting a health center (access = 96.9%, no access = 93.5%, P < 0.001). Participants in both groups had largely positive attitudes around and good knowledge of cervical cancer screening.ConclusionWhile attendance to healthcare services was high amongst participants, those with mobile phone access were more likely to seek healthcare services. Further inquiry into this association between mobile phone access and healthcare‐seeking behavior is needed to optimize the improvements to cervical cancer screening when implementing interventions such as mHealth technology.
An efficient method by combining different basis sets and SAPT levels
Authors: Deng Zhihao , Liu Chang , Li Zhongwei , Zhang Yingsheng 
Published: May 2024

AbstractIn symmetry‐adapted perturbation theory (SAPT), accurate calculations on non‐covalent interaction (NCI) for large complexes with more than 50 atoms are time‐consuming using large basis sets. More efficient ones with smaller basis sets usually result in poor prediction in terms of dispersion and overall energies. In this study, we propose two composite methods with baseline calculated at SAPT2/aug‐cc‐pVDZ and SAPT2/aug‐cc‐pVTZ with dispersion term corrected at SAPT2+ level using bond functions and smaller basis set with MP2 corrections respectively. Benchmark results on representative NCI data sets, such as S22, S66, and so forth, show significant improvements on the accuracy compared to the original SAPT Silver standard and comparable to SAPT Gold standard in some cases with much less computational cost.
The effect of different irrigation activation methods on the penetration of the irrigation solution into the dentinal tubules in teeth with calcium hydroxide applied and oval‐shaped canals: Confocal laser scanning microscope analysis
Authors: Er Karaoğlu Gamze , Aydın Zeliha Uğur 
Published: May 2024

AbstractThis study aimed to evaluate the efficacy of different irrigation techniques including standard needle irrigation (SNI), passive ultrasonic irrigation (PUI), EndoActivator (EA), XP‐Endo Finisher (XPF), photon‐induced photoacoustic streaming (PIPS), and shock wave enhanced emission photo‐acoustic streaming (SWEEPS) systems on the penetration of irrigation solutions into dentinal tubules in teeth with calcium hydroxide (CH) applied and oval‐shaped canals by confocal laser scanning microscope (CLSM). Ninety mandibular incisor teeth with oval‐shaped canals were included in this study. After the preparation of teeth using Resiproc Blue R25 (VDW, Munich, Germany) canals were filled with a paste based on CH. The teeth were stored in 100% humidity at a temperature of 37°C for 14 days. According to the irrigation activation systems, the teeth were divided into six groups (n = 15); SNI, PUI, EA, XPF, PIPS, and SWEEPS. In each group, 3 irrigation/activation cycles of 20 s of irrigation and 20 s of activation were performed with the relevant activation method. The root canals were filled with fluorescein sodium (Sigma, Alldrich Co., St. Louis, MO, USA) and activated with the relevant activation method for 30 s. Specimens were sectioned horizontally to 1 ± 0.1 mm at 2, 5, and 8 mm from the apex and then examined under the CLSM. Maximum penetration depth, maximum penetration area and penetration percentage were measured by using Image J software. Data were analyzed using a two‐way analysis of variance (ANOVA) and posthoc Tukey tests (p = .05). No difference was found between the activation systems in terms of maximum penetration depth and maximum penetration area of irrigation solutions in the apical section (p > .05). The penetration percentage of irrigation solutions was higher in PUI and PIPS compared with EA and XPF at the apical section (p < .05). No difference was found between SNI, PUI, PIPS, and SWEEPS in terms of the penetration percentage of irrigation solutions in all sections (p > .05). The penetration percentage of irrigation solutions was higher in the middle and coronal sections compared to the apical section in EA and XPF (p < .05). Tubule penetration of irrigation solutions in SNI was similar between sections. The Tubule penetration area of irrigation solutions in PUI, EA, XPF, PIPS, and SWEEPS was lower in the apical section than in the middle and coronal sections.Research Highlights
The tubule penetration depth and area of the irrigation solutions were similar between the activation systems tested in the apical sections.
The Tubule penetration area of irrigation solutions in middle and coronal sections was higher in PUI and PIPS than in SNI.
Assessment of Hypoxia in Breast Cancer: Emerging Functional MR Imaging and Spectroscopy Techniques and Clinical Applications
Authors: Daimiel Naranjo Isaac , Bhowmik Arka , Basukala Dibash , Lo Gullo Roberto , Mazaheri Yousef , Kapetas Panagiotis , Eskreis‐Winkler Sarah , Pinker Katja , Thakur Sunitha B. 
Published: May 2024

Breast cancer is one of the most prevalent forms of cancer affecting women worldwide. Hypoxia, a condition characterized by insufficient oxygen supply in tumor tissues, is closely associated with tumor aggressiveness, resistance to therapy, and poor clinical outcomes. Accurate assessment of tumor hypoxia can guide treatment decisions, predict therapy response, and contribute to the development of targeted therapeutic interventions. Over the years, functional magnetic resonance imaging (fMRI) and magnetic resonance spectroscopy (MRS) techniques have emerged as promising noninvasive imaging options for evaluating hypoxia in cancer. Such techniques include blood oxygen level‐dependent (BOLD) MRI, oxygen‐enhanced MRI (OE) MRI, chemical exchange saturation transfer (CEST) MRI, and proton MRS (1H‐MRS). These may help overcome the limitations of the routinely used dynamic contrast‐enhanced (DCE) MRI and diffusion‐weighted imaging (DWI) techniques, contributing to better diagnosis and understanding of the biological features of breast cancer. This review aims to provide a comprehensive overview of the emerging functional MRI and MRS techniques for assessing hypoxia in breast cancer, along with their evolving clinical applications. The integration of these techniques in clinical practice holds promising implications for breast cancer management.Evidence Level5Technical EfficacyStage 1
Self‐media information disclosure and firm productivity
Authors: Huang Yongjian , Zhou Yiqing , Mou Luyao , Li Haolin , Zhang Yining 
Published: May 2024

AbstractUsing Sina Weibo data obtained through crawler technologies from 2013 to 2021, this study investigates the relationship between self‐media information disclosure and firm productivity. We find that self‐media information disclosure promotes firm productivity, a conclusion that withstands various robustness and endogeneity tests. Particularly, original microblogs exhibit a more significant impact. Further analysis reveals that the promoting effect is more pronounced in listed companies with lower annual retweets, small companies, and those with lower turnover. Finally, a mechanism analysis indicates that self‐media information disclosure enhances enterprise productivity by alleviating financing constraints, enhancing corporate innovation, and strengthening corporate governance.
Fast magnetization transfer saturation imaging of the brain using MP2RAGE T1 mapping
Authors: Rowley Christopher D. , Nelson Mark C. , Campbell Jennifer S. W. , Leppert Ilana R. , Pike G. Bruce , Tardif Christine L. 
Published: May 2024

AbstractPurposeMagnetization transfer saturation (MTsat) mapping is commonly used to examine the macromolecular content of brain tissue. This study compared variable flip angle (VFA) T1 mapping against compressed‐sensing MP2RAGE (csMP2RAGE) T1 mapping for accelerating MTsat imaging.MethodsVFA, MP2RAGE, and csMP2RAGE were compared against inversion‐recovery T1 in an aqueous phantom at 3 T. The same 1‐mm VFA, MP2RAGE, and csMP2RAGE protocols were acquired in 4 healthy subjects to compare T1 and MTsat. Bloch‐McConnell simulations were used to investigate differences between the phantom and in vivo T1 results. Ten healthy controls were imaged twice with the csMP2RAGE MTsat protocol to quantify repeatability.ResultsThe MP2RAGE and csMP2RAGE protocols were 13.7% and 32.4% faster than the VFA protocol, respectively. At these scan times, all approaches provided strong repeatability and accurate T1 times (< 5% difference) in the phantom, but T1 accuracy was more impacted by T2 for VFA than for MP2RAGE. In vivo, VFA estimated longer T1 times than MP2RAGE and csMP2RAGE. Simulations suggest that the differences in the T1 measured using VFA, MP2RAGE, and inversion recovery could be explained by the magnetization‐transfer effects. In the test–retest experiment, we found that the csMP2RAGE has a minimum detectable change of 2.3% for T1 mapping and 7.8% for MTsat imaging.ConclusionsWe demonstrated that MP2RAGE can be used in place of VFA T1 mapping in an MTsat protocol. Furthermore, a shorter scan time and high repeatability can be achieved using the csMP2RAGE sequence.
Better off by risk adjustment? Socioeconomic disparities in care utilization in Sweden following a payment reform
Authors: Anell Anders , Dackehag Margareta , Dietrichson Jens , Ellegård Lina Maria , Kjellsson Gustav 
Published: May 2024

AbstractReducing socioeconomic health inequalities is a key goal of most health systems. A challenge in this regard is that healthcare providers may have incentives to avoid or undertreat patients who are relatively costly to treat. Due to the socioeconomic gradient in health, individuals with low socioeconomic status (SES) are especially likely to be negatively affected by such attempts. To counter these incentives, payments are often risk adjusted based on patient characteristics. However, empirical evidence is lacking on how, or if, risk adjustment affects care utilization. We examine if a novel risk adjustment model in primary care affected socioeconomic differences in care utilization among individuals with a chronic condition. The new risk adjustment model implied that the capitation—the monthly reimbursement paid by the health authority to care providers for each enrolled patient—increased substantially for chronically ill low‐SES patients. Yet, we do not find any robust evidence that their access to primary care improved relative to patients with high SES, and we find no effects on adverse health events (hospitalizations). These results suggest that the new risk adjustment model did not reduce existing health inequalities, indicating the need for more targeted incentives and interventions to reach low‐SES groups.
Development of resin‐based dental composites containing hydroxyapatite and zirconia nanoparticles
Authors: Tunca Taşkıran Senagül , Tanoğlu Metin , Çerci Nazife , Cevahir Aref , Türkdoğan Damar Ceren , Ünver Elçin , Aktaş Mustafa İlker 
Published: May 2024

AbstractIn clinical applications, resin‐based dental composites primarily face challenges with fractures and secondary caries. To overcome these issues, the physical characteristics of dental composites, especially mechanical properties, need to be improved. Hydroxyapatite (HA), present in the structure of the teeth, is preferred due to its biological properties, and zirconia (ZrO2) nanoparticles are known to enhance the mechanical properties of this type of composites. The aim of this study is to develop resin‐based dental composites containing HA and ZrO2 nanoparticles. The study also aims to explore the synergistic effect of these two nanoparticles on the physical properties of the developed composites. Composites with nine different compositions were prepared by mixing the components with the help of a mortar mill. The flexural and compressive strength, polymerization shrinkage, depth of cure and water sorption, and solubility properties of the prepared composites have been investigated. All composites have been found to meet the requirements of ISO 4049 standard. Among them, composite containing 5 wt. % HA and 1 wt. % ZrO2 (H5Z1) has exhibited the highest flexural strength with an increase of 58% compared to the control sample, and composite containing 3 wt. % HA and 2 wt. % ZrO2 (H3Z2) has exhibited the highest compressive strength with an increase of 22% compared to the control sample. Other physical properties of the composites have been found to be in an acceptable level.Highlights
Dental composites with HA and ZrO2 fillers were developed by a mortar mill.
Synergistic effect of HA and ZrO2 nanoparticles was investigated.
Mechanical properties of dental composites were significantly improved.
Physical properties of dental composites were found to be at acceptable levels.
Depth of cure decreases with increasing HA and ZrO2 loading.
Shape recovery and energy absorption properties of 3D printed continuous ramie fiber reinforced thin‐walled biocomposite structures
Authors: Lin Hao , Cai Ruijun , Cheng Ping , Wang Jin , Rao Yanni , Peng Yong , Wang Kui , Ahzi Said , Yao Song 
Published: May 2024

AbstractContinuous fiber reinforced composites are widely used in thin‐walled structures due to their high specific strength and stiffness. In this work, continuous natural fiber was introduced into thin‐walled biocomposite structures via 3D printing technique to enhance energy absorbing properties and promote ecological compatibility. The effects of varying configurations of printing speed, layer thickness, and path optimization on the deposition quality of continuous ramie fiber and polylactic acid matrix were explored. The results showed that reduced printing speed (100 mm/min) and optimal layer thickness (0.25 mm) effectively minimized structural forming defects. In addition, further enhancements in the printing quality could be achieved by smoothing the path with rounded corners. Based on optimal printing strategies, different configurations of thin‐walled biocomposite structures were fabricated. Lateral monotonic and cyclic load tests were performed to investigate their energy absorption and shape recovery capacities. When the loading displacement was 10 mm (strain was 20%), the circular structure presented good shape recovery capability, with measured recovery ratio remaining above 89%. The hexagonal structure showed a similar variation in shape recovery ratio as the quadrangular structure, both remaining above 75%. Moreover, the specific energy absorption of all the structures converged after two cycles, indicating their remarkable and stable repeatable load‐bearing capacity.Highlights
Continuous ramie fiber reinforced thin‐walled structures were prepared.
The deformation patterns of structures under lateral compression were analyzed.
Energy absorption and shape recovery radio were studied under cycle loading.
Printed structures exhibited great and stable repeatable load‐bearing capacity.
The Euler Sombor index of a graph
Authors: Tang Zikai , Li Yunping , Deng Hanyuan 
Published: May 2024

AbstractA novel geometric method is proposed for constructing vertex‐degree‐based molecular structure descriptors, which is the perimeter of an ellipse whose focal points represent the degree‐point and its dual‐point of a pair of adjacent vertices in a graph . We first analyze the chemical applicability of this elliptic Sombor index, and then establish its mathematical properties and determine the extremal values for this elliptic Sombor index among all (molecular) trees and characterize the corresponding extremal graphs.