bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bilanz Henkel 2023: Verbinden, schützen, reinigen
Authors: Bulmahn Maren 
Published: April 2024

AbstractHenkel aus Düsseldorf hat umgebaut. Das Kosmetik‐ und Waschmittelgeschäft zusammenzulegen senkte Kosten. Zweites Standbein bleibt das Geschäft rund um Klebstoffe.
Modified SANISAND‐F model for simple shear path
Authors: Huang Xingbo , Sun Yifei , Gu Chenglong 
Published: April 2024

AbstractSimple shear behavior of sand is representative in geotechnical engineering with potential failure occurred along a thin shear zone. The strength and deformation of sand under simple shear are accompanied with principal stress rotation (PSR). This study proposes a modified SANISAND‐F model to capture the simple shear behavior of sand with PSR. A new plastic flow rule along with a kinematic hardening modulus is proposed to consider the evolution of the PSR and intermediate stress ratio. The developed model, with thirteen parameters, can reasonably the capture the stress‐strain and PSR of sand under simple shear.
Treatment at relapse for synovial sarcoma of children and adolescents: A multi‐institutional European retrospective analysis
Authors: Ferrari Andrea , Orbach Daniel , Bergamaschi Luca , Schoot Reineke A. , van Noesel Max M , Di Carlo Daniela , Bisogno Gianni , Alaggio Rita , Milano Giuseppe Maria , Chiaravalli Stefano , Fuccillo Fernando , Laurence Valerie , Corradini Nadege , Gasparini Patrizia , Vennarini Sabina , Pasquali Sandro , Casanova Michela 
Published: April 2024

AbstractPurposeThough the prognosis for pediatric patients with localised synovial sarcoma (SS) is generally good, the chances of being cured after relapse are limited. This study describes a retrospective multi‐institutional series of relapsing SS patients treated at six selected European referral centers for pediatric sarcoma.Patients and methodsThe study included 41 patients <21 years with relapsing SS, treated between 2002 and 2022. The analysis included patient's characteristics at first diagnosis, first‐line treatments, clinical findings at relapse, and second‐line treatment modalities.ResultsThe first relapse occurred within 3–132 months (median 18 months) after first diagnosis and was local in 34%, metastatic in 54%, and both in 12%. Treatment at first relapse included surgery in 56% of cases, radiotherapy in 34%, and systemic therapy in 88%. In all, 36 patients received second‐line medical treatment, that was chemotherapy in 32 cases (with 10 different regimens) and targeted therapy in four. No patient was included in an early‐phase clinical trial as second‐line therapy‐line therapy. Overall response rate was 42%. Median event‐free survival (EFS) was 12 months, postrelapse 5‐year EFS was 15.8%. Median overall survival (OS) was 30 months, postrelapse 5‐year OS was 22.2%. At the Cox's multivariable regression analysis, OS was significantly associated with time and type of relapse.ConclusionPediatric patients with relapsed SS have a poor prognosis and generally receive an individualized approach, due to the lack of a uniform standardized approach. New comprehensive strategies are needed to improve the knowledge on the biologic landscape of SS and develop tailored prospective clinical trials.
Comparison of diterpenoid contents and dissolution profiles of selected Andrographis paniculata crude and extract capsules
Authors: Rangkadilok Nuchanart , Pholphana Nanthanit , Akanimanee Jaratluck , Panomvana Duangchit , Puranajoti Porranee , Songvut Phanit , Satayavivad Jutamaad 
Published: April 2024

AbstractIntroductionAndrographis paniculata (AP) has been approved by the Thai government for the treatment of mild cases of COVID‐19 patients. Increasing use of AP products requires quality control to ensure efficacy and safety. At present, there is no requirement for dissolution test of AP products in the Thai Herbal Pharmacopoeia (THP).ObjectiveThis work aimed to examine the contents and dissolution profiles of active diterpenoids, andrographolide (AP1), 14‐deoxy‐11,12‐didehydroandrographolide (AP3), neoandrographolide (AP4), and 14‐deoxyandrographolide (AP6) in AP capsules available in Thai markets.Materials and MethodsFour extract products (EXT. A–D) and three crude powder products (CRD. A–C) were tested for contents by using HPLC‐DAD. Dissolution profiles of four diterpenoids were investigated in different media (pH 1.2, 4.5, 6.8, and 0.01 N HCl + SLS) with apparatus II (paddle type).ResultsThe AP1 contents were 1.99%–2.90% w/w for crude capsules and 2.84%–16.27% w/w for extract capsules. In the dissolution test, the dissolution percentages of four diterpenoids from crude capsules were higher than those from extract capsules except EXT. A. AP1 in most extract products (EXT. B, C, D) was dissolved in all dissolution media at a lower percentage than the other three diterpenoids. EXT. A (aqueous extract) was the only extract capsule showing the amounts of all diterpenoids dissolved in all media >80% in 45 min.ConclusionThe study demonstrated that AP1 content in AP products complied with the acceptance criteria in the THP (80%–120%), and the weight variation also met the United States Pharmacopeia (USP) requirements. However, different dissolution profiles of AP products may lead to different bioavailability of diterpenoids and further affect their efficacy.
Rising cases of drug‐induced pulmonary fibrosis: Analysis of the Food and Drug Administration Adverse Event Reporting System (FAERS) database, 2000–2022
Authors: McCall Kenneth L. , Hennig Kelsey R. , Abe Zachary T. , Dattler Danielle N. , Hurd Karyssa L. , Portnoy Sophie L. , Zagoria Zoey J. 
Published: April 2024

AbstractPurposePulmonary fibrosis (PF) is a severe, progressive disease, which may be caused by exposure to certain medications.MethodsWe queried the U.S. FDA Adverse Event Reporting System (FAERS) from 2000 to 2022, using the search terms “pulmonary fibrosis” and “idiopathic pulmonary fibrosis” and excluded reports with patients under the age of 18 years, and patients with unknown sex or age. Reports were sorted by generic drug names, counted, and plotted over time using a best‐fit trendline based on an exponential function.ResultsFrom 2000 to 2022, there were 24 095 935 adverse drug events reported in FAERS, of which 17 520 (0.07%) were reported as PF. After excluding reports containing patients with unknown age (5255, 30%), sex (122, 0.7%), and age below 18 years old (155, 0.9%), our study included 11 988 reports. The mean age of the study sample was 66.5 ± 13.1 years, and 6248 patients (52.1%) were male. Plotting the 11 988 reports by year revealed an exponential best fit line (R2 = 0.88) with a positive slope over time. The top five drug classes associated with PF were disease modifying antirheumatic drugs (DMARDs, 39.4%), antineoplastic agents (26.4%), cardiovascular agents (12.6%), corticosteroids (4.6%), and immunosuppressive agents (4.0%).ConclusionA 23‐year analysis of the FAERS database revealed exponentially increasing adverse event reports of PF. Significant annual increases in reporting of PF suspected with DMARDs and antineoplastic agents were identified. Our study highlights important trends, which should be used to guide PF research related to drugs of potential importance.
Lessons learned from a multi‐data source research collaboration: The mirabegron post‐authorization safety study program
Authors: de Vogel Stefan , Seeger John D. , Arana Alejandro , Margulis Andrea V. , McQuay Lisa J. , Perez‐Gutthann Susana , Hallas Jesper , Kristiansen Nina Sahlertz , Linder Marie , Odsbu Ingvild , Suehs Brandon , Xu Yihua , Uribe Claudia , Appenteng Kwame , Robinson Noah Jamie 
Published: April 2024

AbstractBackgroundMany factors contribute to developing and conducting a successful multi‐data source, non‐interventional, post‐authorization safety study (NI‐PASS) for submission to multiple health authorities. Such studies are often large undertakings; evaluating and sharing lessons learned can provide useful insights to others considering similar studies.ObjectivesWe discuss challenges and key methodological and organizational factors that led to the delivery of a successful post‐marketing requirement (PMR)/PASS program investigating the risk of cardiovascular and cancer events among users of mirabegron, an oral medication for the treatment of overactive bladder.ResultsWe provide context and share learnings, including sections on research program collaboration, scientific transparency, organizational approach, mitigation of uncertainty around potential delays, validity of study outcomes, selection of data sources and optimizing patient numbers, choice of comparator groups and enhancing precision of estimates of associations, potential confounding and generalizability of study findings, and interpretation of results.ConclusionsThis large PMR/PASS program was a long‐term commitment from all parties and benefited from an effective coordinating center and extensive scientific interactions across research partners, scientific advisory board, study sponsor, and health authorities, and delivered useful learnings related to the design and organization of multi‐data source NI‐PASS.
Teaching the partial products multiplication algorithm to students who struggle using CRA‐I
Authors: Hinton Vanessa M. , Flores Margaret M. 
Published: April 2024

AbstractEffective mathematics interventions should be explicit and include students’ active involvement with multiple representations of the mathematical concept. The concrete‐representational‐abstract‐integrated (CRA‐I) sequence includes these characteristics and has been shown as an effective practice for students who struggle in mathematics. The purpose of the current study was to use CRA‐I, to teach the partial products algorithm. Three fifth‐grade students receiving Tier 3 instruction within a multi‐tiered system of support participated in the study, using base 10 blocks, number lines, and arrays. The researchers used a multiple probe across students design and collected data regarding students’ progress, mastery, and conceptual understanding. There were functional relations between CRA‐I and each of the skills related to progress, mastery, and conceptual understanding. Implications and conclusions will be discussed.
Fabrication and Optical Measurement of a Suspended Particle Monolayer
Authors: Kim Seonghyeon , Yu Gwang hyeon , Kim Hojin 
Published: April 2024

AbstractThe formation of a particle monolayer after the evaporation of a suspension droplet containing micro/nanoparticles is critical for multiple applications, including cell printing, particle immunoassays, and electronics. However, conventional methods for forming monolayers have limitations in terms of the use of solid substrates to fix them. In this paper, a novel method is proposed for forming a microparticle monolayer suspended in air using a through‐hole chip. Utilizing the strong interactions between particles and solid/liquid interfaces at the microscale, a simple yet robust method is developed to fabricate a suspended monolayer via particle suspension evaporation. The particle layers are classified into four types according to the particle concentration and suspension volume, namely, burst, ring, mono and ring, and multi patterns. Reorganization of the particle monolayer is achieved despite the repetitive solvent reinfusion and evaporation processes. Remarkably, the suspended particle monolayer exhibits superior optical characteristics, with a signal‐to‐noise ratio that is 1.78 times higher in fluorescence measurements than the same particles placed on a glass plate. This suspended particle monolayer can be applied in a variety of fields requiring sensitive and reproducible particle detection.
Effectiveness of constraint‐induced movement therapy (CIMT)—Telerehabilitation compared to traditional CIMT on upper extremity dysfunction of adult chronic stroke patients—A systematic review and meta‐analysis
Authors: Sanchez Leila , Asuncion Benjie Mae , Tayag Kathleen Rhea , Chua Czyrhen , Escandor Selina Jane , Dones Valentin C. 
Published: April 2024

AbstractBackground/ObjectiveConstraint‐induced movement therapy (CIMT), a therapy that encourages the use of the affected upper limb through intensive functional tasks, effectively promotes upper limb function in patients with chronic stroke. This study determined the effectiveness of CIMT using telerehabilitation compared with traditional CIMT in improving mild to moderate upper limb motor function in adult patients with chronic stroke.MethodsEligible studies were identified by searching electronic databases and scanning the reference lists of articles. Review Manager 5.4 was used to determine the pooled mean effect size of the standardized mean difference and 95% confidence interval for the group comparison. Visual heterogeneity, I2 statistic, and chi‐square test were used to measure the heterogeneity between the included studies. We evaluated the quality of evidence using GRADEpro GDT, software for creating evidence summaries and healthcare recommendations.ResultsTwo randomized controlled trials were included in this review. A total of 109 participants (70 male, 39 female) were evaluated. The time since the stroke was ≥6 months in one study and ≥1 year in another study. Improvements in upper limb motor function while performing functional movements were measured using the Wolf Motor Function Test. The evidence for the effectiveness of CIMT using telerehabilitation compared with traditional CIMT in improving the upper extremity function in patients with chronic stroke is of moderate quality. This suggests no significant difference between the groups (mean difference [95% CI]: −0.04 [−0.42, 0.33]).ConclusionsCIMT using telerehabilitation is not superior to traditional CIMT in improving patients' upper extremity motor function with chronic stroke. CIMT using telerehabilitation may improve access to treatment, minimize SARS‐CoV‐2 risk, and reduce travel in patients with chronic stroke.
Corrugated Box Damage Classification Using Artificial Neural Network Image Training
Authors: Holland Sarah , Tavasoli Mahsa , Lee Euihark 
Published: April 2024

ABSTRACTThis paper proposes a novel packaging evaluation method using corrugated box images and an artificial neural network (ANN). An ANN works in a way similar to that of neurons in a human brain: by making connections between a trained dataset and the new images provided after training. The ANN has been implemented in the industry in various ways but limited in packaging evaluation. This paper is focused on the corrugated box damage prediction using ANN with the Orange Data Mining platform. By capturing the damaged corrugated box images with an ANN, damaged products can be identified allowing a decision to be made as to what type of package failure occurred. One of the benefits to using an ANN to evaluate corrugated box images is that it allows for the evaluation of package protection in a real distribution environment as compared to a controlled lab setting. In turn, this reduces the cost of testing, as the package failure will have been identified with the assistance of the ANN, rather than full retesting to identify where damage occurred. This process would also reduce costs associated with the usage of materials for testing, due to the lower number of test samples required.
Sustainable use of a smartphone and regulatory needs
Authors: Kögler Martin , Paulick Katharina , Scheffran Jürgen , Birkholz Mario 
Published: April 2024

AbstractThe significance of information and communication technologies (ICT) for the Paris Climate Agreement is continuously increasing because of its growing energy consumption. Here we examine the question for the smartphone and extend the investigation to more aspects of sustainability. Critical issues are identified for ten UN Sustainable Development Goals. Measurements of smartphone energy consumption show that a significant savings potential can be unlocked by reducing the data outflow and the large amount of personal data stored in data centers. Main discrepancies are also traced to the oligopolistic market structure of operating systems (OSs), messenger services, and social media apps. Technical means for a sustainable smartphone use are suggested as alternative OSs, social media channels of the Fediverse, as well as free and open‐source software. Finally, societal conditions are emphasized to make the market for OSs and apps more diverse so that a sustainable smartphone use can generally prevail.
Multimarket contact between partners and strategic alliance survival
Authors: Ryan‐Charleton Tadhg , Galavan Robert J. 
Published: April 2024

AbstractResearch SummaryThe impact of multimarket contact (MMC) between partners on strategic alliance survival is unclear, even though recent studies have suggested that MMC increases the likelihood of alliance formation. Our study investigates this issue by integrating two mechanisms occurring between multimarket firms: mutual forbearance and technological resource imitation. We argue that MMC between partners deters opportunism in alliances via mutual forbearance, resulting in a positive effect on the likelihood of strategic alliance survival. We also suggest that the positive effect is weakened in two settings with higher risks of technological resource imitation: technological overlap between partners and the presence of R&D activities in an alliance. Evidence from strategic alliances in the global semiconductor industry supports these conclusions.Managerial SummaryRecent research has shown that firms encountering each other in multiple markets are more likely to form strategic alliances, but it is unclear whether these firms are likely to stick together. Our theory suggests that the threat of broad retaliation limits opportunism and increases the likelihood of alliance survival when partners encounter each other in multiple markets. Nonetheless, in settings where partners have similar technologies, or in alliances involving R&D activities, their ability and incentives to copy each other's technological resources offsets the positive effect of multimarket contact on alliance survival. We study strategic alliances in the global semiconductor industry and find evidence consistent with these arguments.
Conductance Quantization in 2D Semi‐Metallic Transition Metal Dichalcogenides
Authors: Lu Zhixing , Hou Songjun , Lin Rongjian , Shi Jie , Wu Qingqing , Lin Luchun , Shi Jia , Yang Yang , Lambert Colin , Hong Wenjing 
Published: April 2024

AbstractConductance quantization of 2D materials is significant for understanding the charge transport at the atomic scale, which provides a platform to manipulate the quantum states, showing promising applications for nanoelectronics and memristors. However, the conventional methods for investigating conductance quantization are only applicable to materials consisting of one element, such as metal and graphene. The experimental observation of conductance quantization in transition metal dichalcogenides (TMDCs) with complex compositions and structures remains a challenge. To address this issue, an approach is proposed to characterize the charge transport across a single atom in TMDCs by integrating in situ synthesized 1T’‐WTe2 electrodes with scanning tunneling microscope break junction (STM‐BJ) technique. The quantized conductance of 1T’‐WTe2 is measured for the first time, and the quantum states can be modulated by stretching speed and solvent. Combined with theoretical calculations, the evolution of quantized and corresponding configurations during the break junction process is demonstrated. This work provides a facile and reliable avenue to characterize and modulate conductance quantization of 2D materials, intensively expanding the research scope of quantum effects in diverse materials.
α‐MnO2 Cathode with Oxygen Vacancies Accelerated Affinity Electrolyte for Dual‐Ion Co‐Encapsulated Aqueous Aluminum Ion Batteries
Authors: Yang Xiaohu , Sun Qiwen , Chai Luning , Chen Song , Zhang Wenming , Yang Hui Ying , Li Zhanyu 
Published: April 2024

AbstractAluminum batteries (ABs) are identified as one of the most promising candidates for the next generation of large‐scale energy storage elements because of their efficient three‐electron reaction. Compared to ionic electrolytes, aqueous aluminum‐ion batteries (AAIBs) are considered safer, less costly, and more environmentally friendly. However, considerable cycling performance is a key issue limiting the development of AAIBs. Stable, efficient, and electrolyte‐friendly cathodes are most desirable for AAIBs. Herein, a rod‐shaped defect‐rich α‐MnO2 is designed as a cathode, which is capable to deliver high performance with stable cycling for 180 cycles at 500 mA g−1 and maintains a discharge specific capacity of ≈100 mAh g−1. In addition, the infiltrability simulation is effectively utilized to corroborate the rapid electrochemical reaction brought about by the defective mechanism. With the formation of oxygen vacancies, the dual embedding of protons and metal ions is activated. This work provides a brand‐new design for the development and characterization of cathodes for AAIBs.
An overview of Black males and mental health in higher education: Implications for practice and research
Authors: Palmer Robert T. , McMickens Tryan L. 
Published: April 2024

AbstractThis article discusses some critical underlying factors that facilitate mental health concerns for Black males in higher education. This article also focuses on the role that student affairs practitioners and faculty can play in supporting Black males on college campuses with mental health needs. This article concludes with recommendations and critical research to further research and practice.
Modeling the fate of microplastics in the Sengkarang Estuary, Pekalongan City, Central Java, Indonesia
Authors: Tristanova Tanya , Ismanto Aris , Widiaratih Rikha , Zainuri Muhammad , Sugianto Denny Nugroho , Rochaddi Baskoro , Ismuniarti Dwi Haryo , Wulandari Sri Yulina , Hernawan Undang , Hadibarata Tony , Anindita Malya Asoka 
Published: April 2024

AbstractPlastic‐containing waste generated from industrial and household activities is usually discharged into rivers. Pekalongan Regency has several rivers that flow into the Java Sea, one of which is the Sengkarang River. Microplastic is a serious pollutant that has prompted enhanced research and experimentation. This study aims to determine the concentration and distribution of microplastics in water and sediment at the mouth of the Sengkarang River, Pekalongan. A total of 10 water samples and five sediment samples were collected from the river body to the deep water area around the Sengkarang River. Modeling of microplastic distribution is made using hydrodynamic modeling and particle tracking models using two‐dimensional mathematical model. The results showed that the abundance of microplastics ranged from 131 to 360 particle/m3 in water samples and 552.5–972.5 particle/kg in sediment samples. The most common types of microplastics found were fibers and fragments. The greatest abundance and distribution of microplastics are found in coastal areas in water samples and mangrove areas in sediment samples. The distribution of microplastics is influenced by tidal currents, wind directions, and also river water discharge.