bluuebunny/crossref_metadata_2025_split huggingface dataset:
RECENT EMPLOYMENT TRENDS IN THE CULTURAL INDUSTRIES IN AMSTERDAM, ROTTERDAM, THE HAGUE AND UTRECHT: A FIRST EXPLORATION
Authors: Kloosterman Robert C. 
Published: September 2010

ABSTRACTCultural industries are becoming in general more important in advanced economies as sources of employment and economic growth. In this paper, a quantitative exploration is given of recent trends in cultural industries in the Netherlands. The data show a rapid rise of employment in the cultural industries in the last decade. Moreover, the four largest cities, although losing some terrain, are important sites for cultural production. Furthermore, in terms of employment Amsterdam still turns out to be the undisputed cultural capital of the Netherlands. The Dutch capital clearly has the edge in all but one of the selected cultural industries. The one notable exception is architectural services. Rotterdam, home base of many famous international architectural firms, is asserting its status as the most important place for this kind of cultural industry in the Netherlands.
Oral zinc sulfate in the treatment of Behcet's disease: A double blind cross‐over study
Authors: SHARQUIE Khalifa E. , NAJIM Rafid A. , AL‐DORI Wisam S. , AL‐HAYANI Raafa K. 
Published: September 2010

ABSTRACTThis was a randomized, controlled, double‐blind trial of zinc sulfate in the treatment of Behcet's disease. Patients with Behcet's disease were recruited in this study between November 2001 and February 2003. A clinical manifestations index (CMI) was calculated for each patient. Serum zinc was estimated in all patients both at the beginning and monthly throughout the trial. Serum zinc levels were estimated from 30 healthy normal subjects matched for age and sex as a control group. Patients were randomly allocated to receive either 100 mg zinc sulfate or identical placebo tablet three times daily in a double‐blind manner. After 3 months of starting treatment, patients were crossed over, that is, patients on placebo received zinc sulfate and vice versa. Mean serum zinc level in Behcet's disease patients was statistically significantly lower than mean serum zinc levels in healthy the control. In group A (started with zinc sulfate), the mean CMI started to decline directly after the first month of therapy with zinc sulfate to significantly lower levels. After shifting to placebo treatment in the fourth month, the mean of CMI started to rise again gradually but remained significantly lower than levels before therapy for the fourth and fifth months. In group B (started with placebo), the mean of CMI remained high for the first 3 months. After crossing over to zinc sulfate in the fourth month, the mean of CMI started to decrease after the fourth month. An inverse correlation between CMI and serum zinc level was found. No side‐effects were seen in either group. In conclusion, zinc sulfate was found to be a good option in the treatment of Behcet's disease.
Negative evaluation of a pathergy test in hepatitis B surface antigen carriers
Authors: ENGIN Burhan , GÜNER Özgür R 
Published: September 2010

ABSTRACTThe different cutaneous manifestations of hepatitis B virus infection have been described in different studies. We proposed to evaluate the frequency of skin pathergy positivity in hepatitis B surface antigen carriers. The study group consisted of 92 hepatitis B surface antigen carriers and 76 healthy individuals as a control group. The pathergy test was applied intradermally to both forearms of the patients and the control subjects. The results of the pathergy test were evaluated. Papule or pustule formation was noted as positive. Four and one of the 92 hepatitis patients and 76 control subjects, respectively, were positive for the pathergy reaction. Evidently, this pathergy test that shows non‐specific skin hyper‐reactivity cannot be used as a clinical marker to indicate hepatitis B surface antigen carriers. The test cannot be used to predict the cutaneous manifestations of hepatitis B infection either.
Necrolytic migratory erythema without glucagonoma in a patient with short bowel syndrome
Authors: NAKASHIMA Hiroko , KOMINE Mayumi , SASAKI Kiyo , MITSUI Hiroshi , FUJIMOTO Manabu , HN Hironobu I , ASAHINA Akihiko , KIKUCHI Kanako , TAMAKI Kunihiko 
Published: September 2010

ABSTRACTNecrolytic migratory erythema (NME) is an uncommon inflammatory dermatosis with a distinctive clinical and histological appearance. It shows irregular erythema, bullae, erosion, crusts and pigmentation. While it is typically associated with glucagonoma, some cases of NME without glucagonoma have been reported. Herein, we report a case of necrolytic migratory erythema associated with malabsorption 30 years after ileocolectomy. She presented erosive erythema with scale or partly flaccid bullae on her intergluteal cleft, buttock and extremities. Her laboratory data revealed essential amino acid deficiency and a slightly decreased serum zinc level, while her plasma glucagon level was low. With diagnosis of non‐glucagonoma‐associated NME with malabsorption due to short‐bowel syndrome, she was treated and improved by i.v. amino acid supplement. Histological findings of NME include necrotic changes of keratinocytes in the upper epidermis, proliferation of those in the lower epidermis and inflammatory cell infiltration of upper dermis. We also examined the expression pattern of epidermal keratins (K6, K10) and Ki‐67, one of the markers of proliferative activity, to assess the proliferation and differentiation of keratinocytes in a NME lesion by immunostaining. The findings with these immunostainings support the characteristics of HE‐staining, and suggest hyponutrition may induce changing differentiation/proliferation of keratinocytes.
Amnia for intractable skin ulcers with recessive dystrophic epidermolysis bullosa: Report of three cases
Authors: HASEGAWA Toshio , MIZOGUCHI Masayuki , HARUNA Kunitaka , MIZUNO Yuki , MURAMATSU Shigenori , SUGA Yasushi , OGAWA Hideoki , IKEDA Shigaku 
Published: September 2010

ABSTRACTRecessive dystrophic epidermolysis bullosa (RDEB) is a disease characterized by recurrent blistering and chronic ulceration of the skin. In these patients, recurrent blisters frequently result in intractable skin ulcers due to impaired wound healing caused by mutations in the type VII collagen gene and malnutrition as well as by increased collagenase activity. To evaluate the efficacy of amnia for intractable ulcers in RDEB, we treated RDEB patients with amnia. The amniotic membrane was simply placed on the cleansed wound surface. The procedure was repeated once a week for up to 10 weeks. As a result, wound conditions improved remarkably after treatment with amnia for 2–10 weeks in all the patients, resulting in total re‐epithelization of the ulcers. Amnia could be an effective therapy for intractable skin ulcers in RDEB patients, and should be considered as a re‐emerging therapeutic option for the disease.
Dermatofibrosarcoma protuberans with atrophic appearance at early stage of the tumor
Authors: HANABUSA Makiko , KAMO Riei , HARADA Teruichi , ISHII Masamitsu 
Published: September 2010

ABSTRACTWe report a case of dermatofibrosarcoma protuberans (DFSP) which had looked like an atrophic plaque on the face for 20 years and been diagnosed as morphea. At the late stage after subsequent development of a nodule, histopathological examinations including immunohistochemical stainings revealed the final diagnosis of DFSP. While DFSP is given typical “protuberant” morphology, our case indicates that DFSP sometimes appears as a non‐protuberant lesion. Some reported variants of non‐protuberant DFSP are suspected to be preceding features at the early stage of DFSP before the protuberant feature occurs. We should take this preprotuberant stage of DFSP into consideration of different diagnoses with non‐protuberant lesions. Histopathological examination and immunohistochemical stainings are necessary for an accurate and early diagnosis of DFSP.
Juvenile psoriatic arthritis carrying familial Mediterranean fever gene mutations in a 14‐year‐old Turkish girl
Authors: YENIAY Betul Sozeri , KARACA Neslihan Edeer , YUKSEL Seciye Eda , MIDYAT Levent , KUTUKCULER Necil 
Published: September 2010

ABSTRACTJuvenile psoriatic arthritis (JPsA) is characterized by asymmetric arthritis of big and small joints, enthesitis, dactylitis, psoriatic skin lesions and nail pitting. Investigators agree that JPsA is a relatively common chronic arthropathy of childhood that differs clinically, serologically, and genetically from both juvenile idiopathic arthritis and juvenile ankylosing spondylitis. Familial Mediterranean fever (FMF) is a multisystemic autosomal recessive disease occasionally accompanied by sacroiliitis. This is characterized by recurrent self‐limited attacks of fever and accompanying abdominal, chest and arthricular pain. We present a 14‐year‐old Turkish girl with JPsA and carrying FMF gene mutations. In this patient, JPsA was diagnosed according to her physical, laboratory and skin biopsy findings and a treatment with methotrexate and sulfasalazine was started. As an inadequate clinical and laboratory response was obtained after the first month of therapy, the patient was investigated for FMF, and was diagnosed by molecular analyses of related gene (E148Q heterozygous/V726A homozygous mutation) besides clinical findings. After 2 weeks of the colchicine treatment, symptoms of the patient regressed and acute phase reactants decreased. To our knowledge, this is the first case presenting with psoriatic arthritis and FMF gene mutations together and responds to colchicine, methotrexate and sulfasalazine dramatically in clinical and laboratory findings. This case has been presented to remind that cases with psoriatic arthritis may also carry mutations in the MEFV gene.
Successful treatment of disseminated superficial actinic porokeratosis with Q‐switched ruby laser
Authors: ITOH Munenari , NAKAGAWA Hidemi 
Published: September 2010

ABSTRACTPorokeratosis, a cutaneous disorder that is characterized histologically by the presence of a “cornoid lamella”, is a progressive disease with limited therapeutic modalities. We report a case of a 61‐year‐old man suffering from disseminated superficial actinic porokeratosis, one of the clinical types of porokeratosis, treated with Q‐switched ruby laser, commonly used for the treatment of pigmented skin diseases. The laser therapy provided striking improvement and no clinical recurrence was noted.
Recurrent sarcoidosis on a scar associated with vitiligo
Authors: DEMIRKÖK Sevtap Sipahi , ARZUHAL Nurcan , DEVRANOĞLU Gevher , DEMIRKESEN Cuyan , TÜZÜN Yalçın 
Published: September 2010

ABSTRACTWe report a case of systemic sarcoidosis, diagnosed 13 years ago by transbronchial biopsy. Our patient had a spontaneous resolution of hilar and mediastinal lymphadenopathy 6 months after diagnosis. She presented with a skin rash on her thyroidectomy scar after a period of 4 years of complete remission. The patient complained that her thyroidectomy incision scar rose up, reddened and hardened. Biopsy of the skin lesion revealed non‐caseating epithelioid granulomas with histiocytes and multinucleated giant cells. She was successfully treated with oral prednisone. Scar sarcoidosis recurred twice in a 7‐year follow‐up period without accompanying systemic sarcoidosis. Vitiligo appeared with the last relapse of scar sarcoidosis. The case we present is of interest due to the recurrent attacks of scar sarcoidosis in a patient during the remission period of systemic sarcoidosis. Another aspect of this case is the association of the disease with vitiligo without any sign of an autoimmune disease.
Knuckle pads associated with clubbed fingers
Authors: KOBA Shinichi , MISAGO Noriyuki , NARISAWA Yutaka 
Published: September 2010

ABSTRACTThe patient was a 37‐year‐old male who visited us for the chief complaints of severely keratinized elastic soft nodules with normal skin color or slightly glossy pale brown color at the distal interphalangeal joints of the bilateral second, third, fourth and fifth fingers associated with bilateral clubbed fingers. The nodules were histopathologically diagnosed as knuckle pads. Clubbed fingers were also noted, but no cardiopulmonary disorder was observed. Knuckle pads are circumscribed fibromatous thickenings of the skin overlying the finger joints. External factors are considered to be the cause, but many cases may be idiopathic such as this case. Many patients with clubbed fingers have underlying cardiopulmonary disorders, and idiopathic development, such as in this case, does not frequently occur. Our patient had the complications of knuckle pads and clubbed fingers, which has not previously been reported.
Establishment of grading criteria for acne severity
Authors: HAYASHI Nobukazu , AKAMATSU Hirohiko , KAWASHIMA Makoto ,   Acne Study Group
Published: September 2010

ABSTRACTFor the epidemiological surveys and evaluations of therapy, it is essential to evaluate the severity of diseases. There are several reported methods of assessment for acne severity including lesion counting, comparison of the patient's to a photographic standard and comparison of the patient's to a text description. But all of these are based on opinions of specialists. In this study, we attempted to make an evidence‐based grading criteria for acne severity, which was expected to yield consents from most dermatologists. The dermatologists consulted classified the global severity of acne patients without any standard and then counted the numbers of eruptions. Three independent expert dermatologists graded the photographs of these patients. We compared the verdicts of the consulted dermatologist and three experienced dermatologists, and analyzed the relationships between these classifications and numbers of eruptions. Our results showed that most of the dermatologists have similar latent recognitions of acne severity. We selected representative photographs as standards, which would contribute to making adjustments for judgments. Global classifications of dermatologists correlated with numbers of inflammatory eruptions (papules plus pustules), but did not with numbers of comedones. The appropriate divisions of inflammatory eruptions of half of the face to decide classifications were: 0–5, “mild”; 6–20, “moderate”; 21–50, “severe”; and more than 50, “very severe”.
Case of unilateral focal dermal hypoplasia (Goltz syndrome)
Authors: AOYAMA Masako , SAWADA Hiroo , SHINTANI Yoichi , ISOMURA Iwao , MORITA Akimichi 
Published: September 2010

ABSTRACTFocal dermal hypoplasia (FDH) is a rare multisystem condition in which developmental defects of the skin are associated with ocular, dental and skeletal abnormalities. Herein, we report an 8‐year‐old girl with FDH. Her body halves were asymmetric and she had linear cutaneous atrophy with yellow nodules on her extremities. Syndactylies of the third and fourth fingers of the right hand and second and third toes of the right foot were also observed. Histological examination revealed dermal hypoplasia and upward extension of the adipose tissue. Based on these observations, she was diagnosed with unilateral FDH.
Effects of narrow‐band ultraviolet B and tazarotene therapy on keratinocyte proliferation and TIG3 expression
Authors: LUO Suju , ZHENG Yan , PENG Zhenhui , JIANG Ju , GONDOKARYONO Srie , WANG Guorong , IKEDA Shigaku 
Published: September 2010

ABSTRACTTazarotene plus narrow‐band ultraviolet B (NB‐UVB) therapy has been shown to enhance the efficacy in treating patients with psoriasis, while the mechanism is not clear. The present study aims to investigate the alteration of cell proliferation and TIG3 in cultured normal human keratinocytes after NB‐UVB and/or tazarotene treatment. Keratinocytes were exposed to NB‐UVB, then incubated with or without tazarotene, and then cell proliferation was detected by methyl thiazoleterazolium colorimetric assay and TIG3 mRNA expression and protein production was examined by real‐time reverse transcription polymerase chain reaction and immunocytochemistry, respectively. The results show that keratinocyte proliferation was inhibited and TIG3 mRNA expression and protein production were elevated by tazarotene at a dose higher than 0.1 µmol/L. In NB‐UVB single irradiating groups, only 200 mJ/cm2 NB‐UVB inhibited keratinocyte proliferation, and none of the irradiated groups had an effect on TIG3 expression. Moreover, tazarotene plus NB‐UVB have stronger effects than those separately. These results indicate NB‐UVB plus tazarotene may have synergistic effects on inhibiting keratinocyte proliferation and elevating TIG3 expression, which may have some implications for the understanding of how to treat psoriasis patients with tazarotene plus NB‐UVB.
The Severity of Alcohol Dependence Questionnaire: Its Use, Reliability and Validity
Authors: Stockwell Tim , Murphy Denis , Hodgson Ray 
Published: September 2010

SummaryThe clinical value of assessing degree of alcohol dependence is discussed in relation to goals of treatment. Further information is then provided on the use, reliability and validity of an instrument designed for this purpose ‐the SADQ. ‘Norms’ for SADQ scores from three samples of problem drinkers are given. Data indicating that individual items, sections and also the total scores of the SADQ have consistently high test‐retest reliability coefficients are presented. A study is described in which a degree of construct validity is established by relating SADQ scores to one important component of the alcohol dependence syndrome [2]‐narrowing of drinking repertoire. In addition, it is shown that SADQ scores have low, but significant, correlations with indicators of withdrawal severity for individuals treated at a Detoxification Unit. SADQ scores failed to correlate with indices of liver functioning. These results are discussed and it is concluded the SADQ is a quick, reliable and valid instrument.
Water repellency of fly ash‐enriched forest soils from eastern Germany
Authors: Hartmann P. , Fleige H. , Horn R. 
Published: September 2010

Fly ash‐enriched soils occur widely throughout the industrial regions of eastern Germany and in other heavily industrialized areas. A limited amount of research has suggested that fly ash enrichment alters the water repellency (WR) characteristics of soil. This study concentrates on the influence of fly ash enrichment on WR of forest soils with a focus on forest floor horizons (FFHs). The soils were a Technosol developed from pure lignite fly ash, FFHs with lignite fly ash, and FFHs without lignite fly ash enrichment. Three different methods (water drop penetration time, WDPT, test; water and ethanol sorptivity measurement and the derived contact angle, θR; and the Wilhelmy‐plate method contact angle, θwpm) were used to characterize soil WR. Additionally, carbon composition was determined using 13C‐NMR spectra to interpret the influence of the organic matter.This study showed that the actual WR characteristics of undisturbed, fly ash‐enriched soils can be explained in terms of the composition of soil organic matter, with the fly ash content playing only a minimal role. Regardless of the huge amounts of mainly mineral fly ash enrichment, all undisturbed FFHs were comparable in their WR characteristics and their carbon compositions, which were dominated by recently‐formed organic substances. The pure fly ash deposit was strongly influenced by lignite remains, with the topsoil having a greater content of recent plant residues. Thus, the undisturbed topsoil was more repellent than the subsoil. When homogenized samples were used, we found a distinct effect of fly ash enrichment and structure on WR. Water repellency of the pure fly ash horizons did not differ distinctly, while the fly ash enrichment in the FFHs caused a significant reduction in WR. The methods used (WDPT, θR and θwpm) identified these differences similarly. These results led to the assumption that water‐repellent structures of the topsoils were probably the result of hydrophobic coatings of recently formed organic substances, whereby the initially high wettability of the mainly mineral, hydrophilic fly ash particles was reduced.
Comparison of the quality of life between HIV‐positive haemophilia patients and HIV‐negative haemophilia patients
Authors: DJULBEGOVIC B. , GOLDSMITH G. , VAUGHN D. , BIRKIMER J. , MARASA M. , JOSEPH G. , HUANG A. , HADLEY T. 
Published: September 2010

Summary. In a prospective study, we tested the hypothesis that an already reduced quality of life in haemophilia patients is further diminished in those haemophilia patients who contracted the human immunodeficiency virus (HIV) as a result of transfusion of coagulation factor preparations. From an available pool of 92 males with haemophilia A or B, 18 patients seropositive for HIV infection and 11 seronegative patients were randomly selected for the study.We applied two instruments to measure the quality of life (QOL) in our patients. The first instrument was the quality of well‐being (QWB) scale that unifies QOL into a single score based upon an assessment of the patient's symptoms and health‐related reductions in mobility, physical activity and social activity. The second instrument was SF‐36, the questionnaire from the Medical Outcome Study (MOS) that measures six dimensions of health status (physical functioning, role functioning, social functioning, pain, mental health and health perception). Measurements were obtained with both instruments at three interviews with each patient over a 1‐year interval.As expected, HIV disease reduces QOL in haemophiliacs. The number of bleeding episodes within 2 months of interview was increased in the HIV‐positive cohort but not within 6 days of interview, indicating that HIV disease independently affects QOL in haemophilia patients. In a typical 30‐year‐old patient, haemophilia itself has reduced quality of their lives by 9.3 years, and HIV disease additionally from 8.5 to 20 years. On the MOS scales, the two patient groups differed significantly only in the dimensions of health perception and pain magnitude. Although HIV disease led to a decrement in QOL of haemophilia patients, it also appears that haemophilia patients are able to develop coping skills to prevent more drastic effects of HIV disease on their QOL. Future studies will need to explore the nature and mechanisms of this ‘buffering’ effect.
Clinical endodontic and surgical management of tooth and associated bone resorption
Authors: HEITHERSAY GEOFFREY S. 
Published: September 2010

Summary. The management of root and bone resorption has been divided on clinical grounds into four categories:(i)conditions that respond to conservative endodontics;(ii) conditions that require surgical endodontics;(iii) conditions that require combined therapy, e.g. endodontics, orthodontics, periodontics, prosthodontics;(iv) conditions that will not respond to, or do not require any, treatment.Using this classification, a conservative treatment rationale based on an understanding of the underlying disease can be evolved.The diagnosis of whether the lesion is internal, external or combined is essential if rational therapy is to be carried out. Internal resorption requires the removal of the blood supply supporting this resorptive defect; the process should cease, provided that this can be effectively achieved.External root resorption is more complicated, requiring either stimulation of natural repair processes by removing the aetiological agents, artificial repair involving the curettage of the defect and the placement of a suitable repair material, or partial or complete resection. Combined therapy involving orthodontic extrusion is useful in some defects at or near the cervical region.Treatment should not be instituted where there is no therapeutic advantage or where the process would naturally cease with the removal of the initiating cause.