bluuebunny/crossref_metadata_2025_split huggingface dataset:
IL10 GGC Haplotype Is Positively and HLA-DQA1*05-DQB1*02 Is Negatively Associated with Radiographic Progression in Undifferentiated Arthritis
Authors: URSUM JENNIE , van der WEIJDEN MIGNON A.C. , van SCHAARDENBURG DIRKJAN , PRINS AREND P.A. , DIJKMANS BEN A.C. , TWISK JOS W.R. , CRUSIUS JAKOB B.A. , van der HORST-BRUINSMA IRENE E. 
Published: May 2010

Objective.In rheumatoid arthritis (RA), many genetic markers, such as the shared-epitope (SE) alleles, are described in association with radiographic progression, but limited data are available on undifferentiated arthritis (UA). We investigated whether single-nucleotide polymorphisms (SNP) and haplotypes in immune response genes and HLA class II alleles are associated with radiographic progression in patients with early UA.Methods.Progression of radiographic damage was determined in white Dutch patients with early UA after 2 years of followup. Severe progression was defined as an increase in Sharp/van der Heijde Score ≥ 5 points after 2 years of followup. The remainder was classified as mild. These SNP were genotyped by Taqman technology: tumor necrosis factor (TNF) −1031, −863, −857, −308, −238; lymphotoxin-α (LTA) +368, +252; interleukin 10 (IL10) −2849, −1082, −819; IL1A −889, IL1B −31, +3953; and IL1RN +2018. Carriage of SE alleles and HLA-DQA1*05-DQB1*02 haplotype was established. These markers were analyzed in relation to radiographic progression.Results.Forty-eight out of 151 patients with early UA had severe radiographic progression. Severe radiographic progression was associated with an increased carrier frequency of SE alleles (OR 5.12, 95% CI 2.0–13.1, p < 0.001) and IL10 GGC haplotype (OR 2.8, 95% CI 1.4–5.8, p = 0.003). Mild radiographic progression was associated with the HLA-DQA1*05-DQB1*02 haplotype (OR 0.3, 95% CI, 0.1–0.8, p = 0.013) and with allele TNF −308A (OR 0.4, 95% CI, 0.2–0.9, p = 0.02).Conclusion.The SE and the IL10 GGC haplotype are associated with severe progression of radiographic damage, in contrast to the DQA1*05-DQB1*02 haplotype and the TNF −308A allele, which are associated with mild radiographic progression in early UA.
Regulation of Chondrogenesis by Transforming Growth Factor-ß3 and Insulin-like Growth Factor-1 from Human Mesenchymal Umbilical Cord Blood Cells
Authors: MARA CRISTIANE S. , DUARTE ADRIANA S.S. , SARTORI ANGELICA , LUZO ANGELA C. , SAAD SARA T.O. , COIMBRA IBSEN B. 
Published: May 2010

Objective.Mature articular cartilage is vulnerable to injuries and disease processes that cause irreversible tissue damage because of its limited capacity for self-repair. Umbilical cord blood is a source of mesenchymal stem cells, which can give rise to cells of different lineages, including cartilage, bone, and fat. Cellular condensation is a required step in the initiation of mesenchymal chondrogenesis. We attempted to differentiate cells from umbilical cord blood into chondrocytes with insulin-like growth factor 1 (IGF-1) and transforming growth factor-ß3 (TGF-ß3).Methods.Cells were grown in high density micromass and monolayer culture systems and then evaluated for expression of type II collagen, aggrecan, and Sox9. Umbilical cord blood from 130 patients was harvested.Results.Expression of type II collagen, aggrecan, and Sox9 was detected after 14 days in TGF-ß3- and IGF-1-stimulated cells in both types of culture (monolayer and micromass). On Day 21 in the micromass culture, expression levels were greater than they were at 14 days for all genes. TGF-ß3 was found to be more efficient at promoting chondrogenesis than IGF-1. By western blot, we also found that after 3 weeks, the expression of type II collagen was greater in micromass culture with TGF-ß3.Conclusion.TGF-ß3 used in micromass culture is the best growth factor for promoting the proliferation and differentiation of mesenchymal cells from umbilical cord blood during chondrogenesis. This approach may provide an alternative to autologous grafting.
Bone Microarchitecture Assessment by High-Resolution Peripheral Quantitative Computed Tomography in Patients with Systemic Lupus Erythematosus Taking Corticosteroids
Authors: LI EDMUND K. , ZHU TRACY Y. , TAM LAI-SHAN , HUNG VIVIAN W. , GRIFFITH JAMES F. , LI TENA K. , LI MARTIN , WONG KONG CHIU , LEUNG PING CHUNG , KWOK ANTHONY W. , QIN LING 
Published: May 2010

Objective.We assessed the relationship between vertebral fracture and bone microarchitecture in patients with systemic lupus erythematosus (SLE) on chronic corticosteroid therapy using high-resolution peripheral quantitative computed tomography (HR-pQCT).Methods.Fifty-nine Chinese women with SLE taking corticosteroid were selected to participate in a cross-sectional study. Vertebral fracture was confirmed semiquantitatively by lateral radiographs of the thoracic and lumbar spine. Density and microarchitecture at the distal radius were measured with HR-pQCT. Areal bone mineral density (aBMD) at hip and lumbar spine was measured by dual-energy x-ray absorptiometry (DEXA).Results.Twelve patients had vertebral fractures. The aBMD of spine or hip did not differ between those with and without vertebral fractures. Measures by HR-pQCT revealed that patients with vertebral fractures had significantly lower level of average bone density (p = 0.007), cortical bone density (p = 0.029), trabecular bone density (p = 0.024), trabecular bone volume to tissue volume (p = 0.023), and trabecular thickness (p = 0.011) than those without vertebral fractures. Independent explanatory variables associated with higher risk of vertebral fractures were older age (p = 0.013) and lower average cortical bone density (p = 0.029).Conclusion.Vertebral fracture in patients with SLE on chronic corticosteroid treatment was associated with alterations of bone density and microarchitectures measured by HR-pQCT and DEXA. However, alterations were more pronounced in measurements by HR-pQCT. Low cortical bone density and old age were significant predictors of vertebral fracture risk.
Folate Pathway Enzyme Gene Polymorphisms and the Efficacy and Toxicity of Methotrexate in Psoriatic Arthritis
Authors: CHANDRAN VINOD , SIANNIS FOTIOS , RAHMAN PROTON , PELLETT FAWNDA J. , FAREWELL VERNON T. , GLADMAN DAFNA D. 
Published: May 2010

Objective.To determine the association between folate pathway gene polymorphisms and the effectiveness, toxicity, and drug survival of methotrexate (MTX) in psoriatic arthritis (PsA).Methods.Data were obtained from a longitudinal cohort of PsA patients evaluated according to a standard protocol. Data on duration of drug therapy, dose, side effects, and reasons for discontinuation are systematically recorded. Patients treated with MTX after clinic admission who had ≥ 3 swollen joints prior to initiating MTX therapy were selected for evaluation of effectiveness. Response to MTX treatment was assessed at 6 months. Data from all patients treated in the clinic with MTX were used in evaluation of toxicity and drug survival. The following single-nucleotide polymorphisms (SNP) were measured using the Sequenom platform: MTHFR 677C>T (rs1801133), MTHFR 1298A>C (rs1801131), DHFR −473T>C (rs1650697), DHFR 35289A>G (rs1232027), and RFC 80G>A (rs1051266). Fisher’s exact test, logistic regression, and Cox proportional hazard analyses were used to determine association.Results.Two hundred eighty-one patients were identified from the database. All patients were included in the analysis for side effects and drug survival, and 119 patients were included in the effectiveness analysis. The minor A allele of DHFR gene at +35289 was the only SNP demonstrating association with response to MTX therapy (OR 2.99, p = 0.02). Patients homozygous for the minor allele of MTHFR 677C/T (677TT) had more liver toxicity (Fisher exact test, p = 0.04).Conclusion.Polymorphisms of the DHFR gene may be associated with MTX efficacy. MTHFR 677TT may have a relationship with MTX-induced liver toxicity in PsA.
Estimated Cutoff Points for the 28-Joint Disease Activity Score Based on C-reactive Protein in a Longitudinal Register of Early Arthritis
Authors: CASTREJÓN ISABEL , ORTIZ ANA M. , TOLEDANO ESTHER , CASTAÑEDA SANTOS , GARCÍA-VADILLO ALBERTO , PATIÑO ESTHER , GONZÁLEZ-ÁLVARO ISIDORO 
Published: May 2010

Objective.To estimate the cutoff points for the 28-joint Disease Activity Score (DAS28) calculated using C-reactive protein (CRP) measurements from patients with early arthritis.Methods.We analyzed data from 568 visits of 207 patients enrolled in our prospective longitudinal register of early arthritis. Six rheumatologists evaluated the degree of disease activity at each visit on the basis of the available clinical data, and the final degree of disease activity was established by consensus. DAS28 values were calculated for each visit using CRP or erythrocyte sedimentation rate (ESR). Through a ROC analysis, cutoff points for both indices, as well as for minimal disease activity (MDA), were selected on the basis of the best tradeoff values between sensitivity and specificity.Results.The cutoff values to classify disease activity with the DAS28-CRP were 2.3, 3.8, and 4.9, considering remission at < 2.3, low disease activity 2.3–3.8, moderate disease activity 3.8–4.9, and high disease activity > 4.9. The cutoff value for MDA when calculated with CRP was 2.6. The area under the ROC curves was always greater for DAS28-CRP than for DAS28-ESR, reaching statistical significance for low/moderate activity and for the MDA.Conclusion.Our study confirms that the cutoff points for DAS28-CRP are lower than those described for DAS28-ESR, suggesting that DAS28-CRP may be more accurate to assess disease activity in our population.
Baseline Serum Concentrations of TRAIL in Early Rheumatoid Arthritis: Relationship with Response to Disease-modifying Antirheumatic Drugs
Authors: SECCHIERO PAOLA , CORALLINI FEDERICA , CASTELLINO GABRIELLA , BORTOLUZZI ALESSANDRA , CARUSO LORENZO , BUGATTI SERENA , BOSCO RAFFAELLA , MONTECUCCO MAURIZIO , TROTTA FRANCESCO 
Published: May 2010

Objective.To assess the relationship between serum concentrations of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and osteoprotegerin (OPG) and the therapeutic response to disease-modifying antirheumatic drugs (DMARD) in patients with early rheumatoid arthritis (RA).Methods.Circulating levels of TRAIL and its soluble receptor OPG were measured by ELISA in paired serum samples obtained from 66 patients with early RA at their first visit (baseline) and after 1 year of therapy. Levels of TRAIL and OPG were analyzed in relation to the clinical response, defined by the 28-joint count Disease Activity Score (DAS28).Results.Both serum TRAIL and OPG increased after DMARD therapy. Baseline levels of TRAIL, but not OPG, were significantly higher (p < 0.05) in the patients that achieved a clinical response by DAS28 after 1 year of therapy, versus patients without clinical response to DMARD. Baseline serum levels of TRAIL were higher (p < 0.01) in rheumatoid factor-negative patients.Conclusion.Our data suggest that the basal level of circulating TRAIL is an important determinant in the therapeutic response to DMARD in patients with early RA.
Systemic Lupus Erythematosus, Rheumatoid Arthritis, and Postarthroplasty Mortality: A Cross-sectional Analysis from the Nationwide Inpatient Sample
Authors: DOMSIC ROBYN T. , LINGALA BHARATHI , KRISHNAN ESWAR 
Published: May 2010

Objective.Systemic lupus erythematosus (SLE) is a disease of considerable morbidity, and this may place patients at greater risk for poor in-hospital postoperative outcomes for procedures such as arthroplasty. Our aim was to test this hypothesis.Methods.We compared the in-hospital postoperative mortality risk for patients with SLE undergoing hip and knee arthroplasty to those with rheumatoid arthritis (RA) and the general population without either condition, using data from the Nationwide Inpatient Sample (1993–2006). We performed parallel, weighted, multivariable logistic regressions to calculate mortality risk stratified by joint site, type of admission, hospital type, income category, race, length of stay, surgical indication, and medical comorbidities.Results.The unadjusted mortality rates (per 1000 procedures) for patients with SLE, patients with RA, and controls were 7.4, 3.0, and 6.5, respectively, for nonelective procedures and 2.4, 1.3, and 1.8 for elective procedures. After adjustment for potential confounders, patients with SLE had an OR of 4.0 (95% CI 1.9–8.0) for postoperative mortality with hip replacements and an OR of 1.2 (95% CI 0.2–7.5) for mortality with knee replacements. Mortality risk of patients with RA was not different from that of controls. The adjusted risk estimates for those who underwent arthroplasty before and after 2002 and those who underwent surgery for nonfracture indications were similar.Conclusion.Arthroplasty, especially of hips, in patients with SLE is associated with relatively higher postoperative mortality risk.
Determination of %polyvinyl alcohol in vinyl acetate‐alcohol resins by quantitative near infrared spectroscopic analysis
Authors: Patel S. H. , Bakeev Katherine A. , Chen Gary , Zhang Qi , Wan Chen 
Published: May 2010

AbstractA number of vinyl acetate‐alcohol resins (VAAR) samples were collected during partial hydrolysis of poly(vinyl acetate) at different conversions levels (<30%). Using these VAAR samples with known OH (hydroxyl) content, it has been demonstrated that near infrared (NIR) spectroscopic data produced a near perfect fit for the calibration of OH content. A 4‐factor partial least‐squares method was employed and gave the best results. Further work also confirmed that NIR, operating at a well‐controlled environment, is able to quantify, with great precision, the OH content of the selected model compound. In the case for the OH content analysis of VAAR resins, solvent mix ratio (methyl acetate: methanol) and temperature have been identified to be the two most influential factors on the analytical results. © 2010 Wiley Periodicals, Inc. Adv Polym Techn 29:1–10, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/adv.20166
ChemInform Abstract: Physicochemical Properties and Structural Refinement of Strontium‐Lead Hydroxyapatites.
Authors: Badraoui Bechir , Bigi Adriana , Debbabi Mongi , Gazzano Massimo , Roveri Norberto , Thouvenot Rene 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Homoleptic Tetrahydrometalate Anions MH4‐ (M: Sc, Y, La). Matrix Infrared Spectra and DFT Calculations.
Authors: Wang Xuefeng , Andrews Lester 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regio‐ and Stereoselective Synthesis of Isoxazolines via Cycloaddition Reactions Using Pregnenolone as Chiral Auxiliary.
Authors: Sharma Utpal , Bora Utpal , Chetia Apurba , Boruah Romesh C. , Sandhu Jagir Singh 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Microwave Promoted Selective Preparation of Acetals and Esters from Aldehydes.
Authors: Borah Ruli , Kalita Dipok J. , Sarma Jadab C. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient Method for the Cleavage of p‐Methoxybenzylidene (PMP), Tetrahydropyranyl (THP) and 1,3‐Dithiane Protecting Groups by Selectfluor.
Authors: Liu Junjie , Wong Chi‐Huey 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Palladium‐ or Nickel‐Catalyzed Cross‐Coupling of Organotitanium Reagents with Aryl Triflates and Halides.
Authors: Han Jin Wook , Tokunaga Norihito , Hayashi Tamio 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Symmetrical and Inherently Chiral Water‐Soluble Calix[4]arenes Bearing Dihydroxyphosphoryl Groups.
Authors: Tairov Maxim A. , Vysotsky Myroslav O. , Kalchenko Olga I. , Pirozhenko Vladimir V. , Kalchenko Vitaly I. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Unusual Transannular Rearrangement of a [2.2]Paracyclophane Derivative to Yield the First [6.2.2]Cyclophane (II).
Authors: Pelter Andrew , Harrison‐Marchand Anne , Maxwell Anderson , Mootoo Baldwin , Reid Alicia , Coles Simon J. , Hursthouse Michael B. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Strategies for the Synthesis of ′Through‐Space′ Chromophore Dimers Based on [2.2]Paracyclophane.
Authors: Bartholomew Glenn P. , Bazan Guillermo C. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Zirconium‐Mediated Intramolecular Ester Transfer Reaction: Synthesis of α‐Substituted γ‐Aminobutyric Acid (GABA) Derivatives.
Authors: Ito Hisanaka , Omodera Katsunori , Takigawa Yasushi , Taguchi Takeo 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mn(III)‐Mediated Radical C—C Bond Formation: Regioselective α′‐Allylation of α,β‐Unsaturated Ketones.
Authors: Tanyeli Cihangir , Oezdemirhan Devrim 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Design, Synthesis, and SAR of Substituted Acrylamides as Factor Xa Inhibitors.
Authors: Song Yonghong , et al. et al. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Direct Synthesis of 5‐Substituted Naphthoquinones.
Authors: Kraus George A. , Kim Junwon 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Benzo[a]heptalenes via Benzanellation—Aromatization Sequence.
Authors: Ochertyanova Ekaterina A. , Hansen Hans‐Juergen 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reactions of Carbanions of Bis(dialkoxyphosphoryl)bromomethane with Fullerenes C60 and C70.
Authors: Nuretdinov I. A. , Gubskaya V. P. , Shishikina N. I. , Fazleeva G. M. , Berezhnaya L. Sh. , Karaseva I. P. , Sibgatullina F. G. , Zverev V. V. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Diastereoselective Aziridination of Imines with Trimethylsilyldiazomethane. Subsequent Silyl Substitution with Electrophiles, Ring Opening, and Metalation of C‐Silylaziridines — A Cornucopia of Highly Selective Transformations.
Authors: Aggarwal Varinder K. , Alonso Emma , Ferrara Marco , Spey Sharon E. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Selective Oxidation of N‐Alkyl Imines to Oxaziridines Using UHP/Maleic Anhydride System.
Authors: Damavandi Jafar Asgarian , Karami Bahador , Zolfigol Mohammad Ali 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereospecific β‐Lithiation of Oxazolinyloxiranes: Synthesis of α,β‐Epoxy‐γ‐butyrolactones
Authors: Capriati Vito , Degennaro Leonardo , Favia Raffaele , Florio Saverio , Luisi Renzo 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.