bluuebunny/crossref_metadata_2025_split huggingface dataset:
A single-dose, randomized, open-label, four-period, crossover equivalence trial comparing the clinical similarity of the proposed biosimilar rupatadine fumarate to reference Wystamm® in healthy Chinese subjects
Authors: Lin Sisi , Lou Yutao , Hao Rui , Shao Yiming , Yu Jin , Fang Lu , Bao Meihua , Yi Wu , Zhang Yiwen 
Published: May 2024

PurposeThe aim of this study was to evaluate the bioequivalence of two formulations of rupatadine (10-mg tablets) under fasting and fed conditions in healthy Chinese subjects.MethodsA total of 72 subjects were randomly assigned to the fasting cohort (n = 36) and fed cohort (n = 36). Each cohort includes four single-dose observation periods and 7-day washout intervals. Blood samples were collected at several timepoints for up to 72 h post-dose. The plasma concentration of rupatadine and the major active metabolites (desloratadine and 3-hydroxydesloratadine) were analyzed by a validated HPLC–MS/MS method. The non-compartmental analysis method was employed to determine the pharmacokinetic parameters. Based on the within-subject standard deviation of the reference formulation, a reference-scaled average bioequivalence or average bioequivalence method was used to evaluate the bioequivalence of the two formulations.ResultsFor the fasting status, the reference-scaled average bioequivalence method was used to evaluate the bioequivalence of the maximum observed rupatadine concentration (Cmax; subject standard deviation &gt; 0.294), while the average bioequivalence method was used to evaluate the bioequivalence of the area under the rupatadine concentration–time curve from time 0 to the last detectable concentration (AUC0-t) and from time 0 to infinity (AUC0-∞). The geometric mean ratio (GMR) of the test/reference for Cmax was 95.91%, and the upper bound of the 95% confidence interval was 95.91%. For AUC0-t and AUC0-∞ comparisons, the GMR and 90% confidence interval (CI) were 98.76% (93.88%–103.90%) and 98.71% (93.93%–103.75%), respectively. For the fed status, the subject standard deviation values of Cmax, AUC0-t, and AUC0-∞ were all &lt;0.294; therefore, the average bioequivalence method was used. The GMR and 90% CI for Cmax, AUC0-t, and AUC0-∞ were 101.19% (91.64%–111.74%), 98.80% (94.47%–103.33%), and 98.63% (94.42%–103.03%), respectively. The two-sided 90% CI of the GMR for primary pharmacokinetic endpoints of desloratadine and 3-hydroxydesloratadine was also within 80%–125% for each cohort. These results met the bioequivalence criteria for highly variable drugs. All adverse events (AEs) were mild and transient.ConclusionThe test drug rupatadine fumarate showed a similar safety profile to the reference drug Wystamm® (J. Uriach y Compañía, S.A., Spain), and its pharmacokinetic bioequivalence was confirmed in healthy Chinese subjects based on fasting and postprandial status.Clinical trial registration:http://www.chinadrugtrials.org.cn/index.html, identifier CTR20213217
Using machine learning algorithms and techniques for defining the impact of affective temperament types, content search and activities on the internet on the development of problematic internet use in adolescents’ population
Authors: Jović Jelena , Ćorac Aleksandar , Stanimirović Aleksandar , Nikolić Mina , Stojanović Marko , Bukumirić Zoran , Ignjatović Ristić Dragana 
Published: May 2024

BackgroundBy using algorithms and Machine Learning – ML techniques, the aim of this research was to determine the impact of the following factors on the development of Problematic Internet Use (PIU): sociodemographic factors, the intensity of using the Internet, different contents accessed on the Internet by adolescents, adolescents’ online activities, life habits and different affective temperament types.MethodsSample included 2,113 adolescents. The following instruments were used: questionnaire about: socio-demographic characteristics, intensity of the Internet use, content categories and online activities on the Internet; Facebook (FB) usage and life habits; The Internet Use Disorder Scale (IUDS). Based on their scores on the scale, subjects were divided into two groups – with or without PIU; Temperament Evaluation of Memphis, Pisa, Paris, and San Diego scale for adolescents (A-TEMPS-A).ResultsVarious ML classification models on our data set were trained. Binary classification models were created (class-label attribute was PIU value). Models hyperparameters were optimized using grid search method and models were validated using k-fold cross-validation technique. Random forest was the model with the best overall results and the time spent on FB and the cyclothymic temperament were variables of highest importance for these model. We also applied the ML techniques Lasso and ElasticNet. The three most important variables for the development of PIU with both techniques were: cyclothymic temperament, the longer use of the Internet and the desire to use the Internet more than at present time. Group of variables having a protective effect (regarding the prevention of the development of PIU) was found with both techniques. The three most important were: achievement, search for contents related to art and culture and hyperthymic temperament. Next, 34 important variables that explain 0.76% of variance were detected using the genetic algorithms. Finally, the binary classification model (with or without PIU) with the best characteristics was trained using artificial neural network.ConclusionVariables related to the temporal determinants of Internet usage, cyclothymic temperament, the desire for increased Internet usage, anxious and irritable temperament, on line gaming, pornography, and some variables related to FB usage consistently appear as important variables for the development of PIU.
Mental health inequality between urban and rural youth under COVID-19 from survey data from China
Authors: Xiao Yang 
Published: May 2024

BackgroundWhile health inequality has been the focus of past scholarly discussions, COVID-19’s outbreak and spread have provided a new arena for discussing health inequality, particularly in the context of urban–rural disparities in China. This paper explores the impact of COVID-19 on urban–rural health inequality, and the roles played by socioeconomic status and social capital.MethodsA cross-sectional observational collected data on demographics, mental health, socioeconomic status, and social capital. An online survey was administered from August 27 to August 30, 2020, and, 1936 valid samples were received. Mental health was measured using the Brief Symptom Inventory (BSI-18). This study applied the ordinary least squares regression (OLS) model, and data analysis was performed using STATA.ResultsThere were 1936 participants, with an equal distribution of genders. Multiple regression analysis showed that the mental health levels of rural youth were superior to those of urban youth (p = 0.049), especially when the epidemic was not severe (p = 0.013). Socioeconomic status had a significant positive promotion effect on mental health (p = 0.008), but the interaction effect between socioeconomic status and the urban–rural divide indicated that the promotion effect of socioeconomic status on the mental health of urban youth was greater than that of rural youth (p = 0.04). Social capital had a significant positive promotion effect on mental health (p = 0.000), and the interaction effect indicated that this promoting effect did not differ between urban and rural areas (p &gt; 0.05).
Bibliometric analysis of most cited Peyronie's disease and its management publications
Authors: Şahin Mehmet Fatih , Doğan Çağrı , Akgül Murat , Yazıcı Cenk Murat , Şeramet Serkan , Dayısoylu Hulusi Sıtkı 
Published: May 2024

IntroductionPeyronie's disease (PD) is a common urologic illness, motivating numerous scientific investigations and publications. Scientific publications have more authors each year. A bibliometric review of the PD literature might help urologists and sexual medicine professionals comprehend publication tendencies in this subject. The current study was aimed at presenting a bibliometric analysis of PD, which is one of the important and trending subjects of andrology.MethodsOn January 5, 2023, Web of Science scanned documents with the terms Peyronie's disease” “Peyronie's disease treatment”, “Peyronie's disease management”, “Peyronie's disease surgery” and “Peyronie's disease injection” from 1975 through 2023. Titles, years, authors, citations, citation indices, journal names, authors' countries of origin, article categories, and funding sources were recorded.Results“Clinical Efficacy, Safety and Tolerability of Collagenase Clostridium Histolyticum for the Treatment of Peyronie Disease in 2 Large Double-Blind, Randomized, Placebo Controlled Phase 3 Studies” has the most citations and citation index. Most of the T100 articles were published in 2020, primarily in the Journal of Urology. These articles mainly focused on treatment, especially surgeries. All of these articles were in English, and the vast majority of them were by authors from the US who were most frequently collaborated with by other authors.ConclusionThis research analyzed the top 100 PD studies. This research focused on pathophysiology, innovative surgical procedures, and new approaches of PD. It also recommended bigger databases and more financing for research.
Analisis Persepsi Terhadap Teknologi Augmented Reality Dalam Kegiatan Pembelajaran Di Kota Jambi Menggunakan Technology Acceptance Model (TAM) (Studi Kasus : SD, SMP, SMA ATTAUFIQ)
Authors: Muhammad Fahmi1 Said , Jasmir  , Rianti Agustini Silvia 
Published: May 2024

Teknologi merupakan suatu hal yang selalu dan akan terus berkembang seiring dengan perkembangan zaman. Kian hari, berbagai macam teknologi baru bermunculan. Penelitian ini bertujuan untuk menganalisis persepsi penggunaan teknologi Augmented Reality dalam pembelajaran Model pengukuran yang akan digunakan dalam penelitian ini adalah Technology Acceptance Model (TAM) yang dikembangkan oleh Davis dalam penelitian ini memiliki 3 hipotesis Model dan hipotesis divalidasi melalui kuesioner online yang melihatkan 72 responden Guru di SD, SMP, dan SMA Attaufiq Kota Jambi. Data penelitian diolah menggunakan metode Structural Equation Model (SEM) melalui software SmartPLS versi 3. Hasil penelitian menunjukkan Persepsi Kemudahan berpengaruh secara signifikan terhadap variabel Sikap dengan t-stastistik > nilai t-tabel, yakni 4.934> 1,96, Persepsi Kegunaan berpengaruh secara signifikan terhadap variabel Sikap dengan t-statistik > nilai t-tabel,yakni 2.647 >1,96, dan Sikap berpengaruh secara signifikan terhadap variabel Niat untuk menggunakan dengan t-stastistik > nilai t-tabel, yakni 2.599 > 1,96.
Cardiac Complications of Endocrine Diseases: A Literature Review
Authors: Воронин И.М. , Керимова Ф.Г. , Хворостова А.А. , Касьянова Е.А. , Саидов М.С. , Казарян А.С. , Павлов Б.В. 
Published: May 2024

Эндокринные нарушения почти во всех случаях приводят к патологическому изменению метаболизма, включая дислипидемии и ухудшение обмена углеводов. Так, недостаточный контроль гликемии при сахарном диабете способствует повышению уровня триглицеридов и развитию атерогенной дислипидемии. В свою очередь это способствует изменениям в сердечно-сосудистой системе на структурном и функциональном уровне. Частыми явлениями могут быть: повышение жесткости артериальной стенки, гипертензии, кардиомиопатии, атеросклероз сосудов, ишемическая болезнь сердца и сердечная недостаточность. Гиперхолестеринемия способствует возникновению микрососудистых повреждений, повышению вязкости крови, воспалению, тромбозу, окклюзии сосудов, атерогенезу. Кроме того, эндокринные заболевания активируют и другие патогенные механизмы, включая усиление чувствительности миокарда к адренергической системе и прямое токсическое действие на сердечную мышцу. При отсутствии своевременного и адекватного лечения возрастают риски смерти от поздних сердечно-сосудистых осложнений. Правильно подобранная терапия позволяет не только нормализовать обмен веществ, но и значительно нивелировать патологические процессы в кардиоваскулярной области или отодвинуть время их возникновения на поздний этап жизни.
Endocrine disorders in almost all cases lead to pathological changes in metabolism, including dyslipidemia and deterioration of carbohydrate metabolism. Thus, insufficient glycemic control in diabetes mellitus contributes to an increase in triglyceride levels and the development of atherogenic dyslipidemia. In turn, this promotes changes in the cardiovascular system at the structural and functional level. Frequent phenomena may include: increased stiffness of the arterial wall, hypertension, cardiomyopathy, vascular atherosclerosis, coronary heart disease and heart failure. Hypercholesterolemia contributes to the occurrence of microvascular damage, increased blood viscosity, inflammation, thrombosis, vascular occlusion, and atherogenesis. In addition, endocrine diseases activate other pathogenic mechanisms, including increased sensitivity of the myocardium to the adrenergic system, and a direct toxic effect on the heart muscle. In the absence of timely and adequate treatment, the risks of death from late cardiovascular complications increase. Properly selected therapy allows not only to normalize metabolism, but also to significantly neutralize pathological processes in the cardiovascular area or push back the time of their occurrence to a later stage of life.
Cardiac Amyloidosis: A Case Report
Authors: Каленчиц Т.И. , Кабак С.Л. , Котешова Г.В. , Диденко Н.С. , Глушко И.В. , Гребенюк И.А. 
Published: May 2024

В статье обсуждаются результаты обследования 63-летней женщины, госпитализированной с хронической сердечной недостаточностью на фоне кардиомиопатии неуточненного генеза. За три месяца до госпитализации пациентки при проведении биопсии слизистой оболочки прямой кишки были выявлены отложения амилоида. Для установления причины кардиомиопатии был проведен ряд диагностических тестов. По данным эхокардиографии полости левой половины сердца расширены, нарушена локальная сократимость миокарда левого желудочка и произошла его концентрическая гипертрофия. При магнитно-резонансной томографии выявлены признаки рестриктивной кардиомиопатии, которые проявлялись нарушением локальной сократимости миокарда желудочков и их систолической дисфункцией без расширения полостей сердца. При исследовании с контрастным усилением обнаружено распространенное субэндокардиальное, субэпикардиальное, очаговое интрамуральное накопление контрастного вещества в миокарде левого желудочка, а также в стенках правого желудочка, предсердий, структурах предсердно-желудочковых клапанов. Диагностирован двусторонний гидроторакс и перикардиальный выпот. В биоптате костного мозга обнаружено присутствие 2,5% клональных плазматических клеток. Получен отрицательный результат анализа крови на генодиагностику ATTR-амилоидоза. Уровни маркеров сердечного поражения тропонина и NTproBNP составили 181 нг/л и 6689 нг/мл соответственно. Полученные результаты диагностических тестов доказывают, что причиной кардиомиопатии, которая привела к хронической сердечной недостаточности, является AL-амилоидоз.
In this report, we present a clinical case of a 63-year-old female patient with chronic heart failure (CHF) due to cardiomyopathy of unknown origin whose rectal biopsy revealed amyloid deposits 3 months before hospitalization. Some diagnostic tests were performed to determine the cause of cardiomyopathy. According to echocardiography, left heart chambers were dilated, local contractility of the left ventricular myocardium was impaired and its concentric hypertrophy has occurred. Cardiac magnetic resonance imaging revealed signs of restrictive cardiomyopathy, which were manifested by impaired local contractility of the ventricles and their systolic dysfunction without dilatation of the heart chambers. A contrast-enhanced study revealed spread subendocardial, subepicardial and focal intramural late gadolinium enhancement in the walls of the heart chambers and atrioventricular valves. Bilateral hydrothorax and pericardial effusion were diagnosed. The bone marrow biopsy revealed the presence of 2.5% clonal plasma cells. A genetic blood testing did not find genetic change known to cause hereditary transthyretin amyloidosis (ATTR amyloidosis). Levels of cardiac biomarkers troponin and NPproBNP were 181 ng/L and 6689 ng/ml, respectively.
Content transformations in DOU during martial law
Authors: Tsurina Eleonora 
Published: May 2024

The article deals with the impact of the full-scale phase of the Russian-Ukrainian war on the content of Ukrainian field-specific media using the сase of the outlet for IT-specialists DOU. It was chosen as a large online resource with a potential audience of almost 700 000 registered users. The feed of DOU where journalistic materials are published (interviews, articles, investigations, news) is analyzed.
The relevance of the study is due to the threat of the disappearance of Ukrainian field-specific media, which appeared at the beginning of the full-scale invasion because of a significant narrowing the range of topics demanded by the audience.
Interviews with the chief editors of DOU's feed, who held this position during 2022, and the internal editorial statistics made it possible to follow the changes in the thematic, genre and format content of the media.
The most popular topics of the materials published in the feed during 2021—2022 were analyzed and compared. It was found that analytics remains to be the most demanded among readers, but it shows almost double decrease from 63,1 to 33,3%. The second most popular topic in 2022 was the mobilization at 22,2%. Such topics as entry into the profession and high salaries retained their popularity and the first one even increased the rates by 3 times. Materials about relocation and interviews with interesting speakers (outside the war context) completely disappeared from the top due to a change in audience priorities and the current situation.
The most important content transformations in DOU during the year of the full-scale war are highlighted: an increase in the number of news, a linking to the agenda, a presentation of current national topics through the stories of IT specialists, an expansion of genre and format boundaries, an influence of the social mission on the content. It was concluded that such changes can be considered as adaptation measures of the media. The reduction of reader's interest to military topics during the first half of 2022 is tracked.
The analyzed general statistics of views during 2021—2022 allow us to designate the success of the content transformations in the feed of the Ukrainian outlet DOU.
Program Gemarikan Sebagai Upaya Meningkatkan Gizi dan Kecerdasan Anak Usia Dini Pada TK Aisiyah Bustanul Athfal 1 Dadapan Banyuwangi
Authors: Ningrum Nadiya Lifa , Khoiruman Muhamad Alfi , Satriyo Galih , Istiari Nina Ruly , Pratiwi Yosi Mulyana , Rochman Saiful , Suwarso Suwarso , Irawan Doni Hadi , Candra Jovi , Janoko Janoko 
Published: May 2024

Pengabdian kepada masyarakat ini dilatarbelakangi oleh adanya permasalahan yang menunjukkan kurangnya minat untuk anak-anak TK dalam mengkonsumsi ikan laut karena sebagian besar alasannya rasanya terkesan amis dan juga ada yang beberapa siswa yang alergi gatal dll. Selain itu kurangnya pendorong dalam edukasi mengkonsumsi ikan laut juga menjadi permasalahan pada mitra, sehingga perlunya sosialisasi terkait kandungan ikan laut diadakan pada TK Aisiyah Bustanul Athfal 1 Dadapan Banyuwangi agar semua pihak lebih sadar untuk gemar konsumsi ikan laut. Permasalahan terakhir yakni belum ada program gemar makan ikan hanya program makan sehat saja, sehingga perlu ditingkatkan menjadi program Gemarikan agar bisa meningkatkan konsumsi ikan laut dan menjadi TK percontohan yang telah melakukan program Gemarikan. Adapun tujuan dalam kegiatan pengabdian kepada masyarakat ini untuk memberikan edukasi kepada guru, orang tua walimurid TK untuk lebih sadar dan berinovasi dalam mengolah ikan laut agar anak-anak menyukai konsumsi ikan laut karena manfaat ikan laut yang mengandung omega 3 yang baik untuk perkembangan otak anak usia dini. Berdasarkan dari hasil kegiatan yang telah dilakukan ini yakni program GEMARIKAN sangat dibutuhkan untuk anak usia dini dengan memberikan edukasi kepada guru, walimurid dan mencontohkan atau mempraktekkan secara langsung untuk mengkonsumsi ikan laut. Setelah kegiatan pengabdian kepada masyarakat (Gemarikan) ini diharapkan dengan membuat program gemar ikan yang mewajibkan mengkonsumsi laut kepada murid-murid TK Aisiyah Bustanul Athfal 1 Dadapan Banyuwangi. Program wajib mengkonsumsi laut dilakukan satu bulan satu kali oleh murid-murid TK Aisyiyah Bustanul Athfal 1 Dadapan Banyuwangi dengan cara makan bersama-sama dikelas.
Identitas Visual pada Signage System di Borma Setiabudi Bandung
Authors: Nibras Fatih , Vanya Azizah Hamida2  , Prathya Tyara Sagarmatha3  , Mohammad Akmal Zaky Putra Kusumah4  , Teuku Muhammad Daffa Arullah5  
Published: May 2024

The many aisles with various types of goods in Borma Setiabudi make appropriate signage and wayfinding systems as well as visual identity very necessary so that visitors can find the goods they want easily. This is important for managing visitors, especially new visitors who are trying to find the items they are looking for when shopping. This research aims to analyze the visual identity contained in the signage that has been installed in Borma Setiabudi using a qualitative descriptive method, data was collected through direct observation in Borma complete with documentation of the signage. This research produces a comparison of existing signage in Borma Setiabudi with the criteria and regulations for making signage, apart from that, it also includes a comparison of relevant research results which also discuss visual identity and signage systems for other shopping centers in the Bandung area. This research resulted in the need for a plan to create a signage system that complies with regulations and standards in Borma because the existing signage does not meet the existing criteria. Adjustment and rework of signage is necessary to convey it more effectively to visitors.
Keywords : Visual Identity, Signage System, Shopping Center
Temporal context effects on suboptimal choice
Authors: McDevitt Margaret A. , Pisklak Jeffrey M. , Dunn Roger M. , Spetch Marcia L. 
Published: May 2024

AbstractChoice can be driven both by rewards and stimuli that signal those rewards. Under certain conditions, pigeons will prefer options that lead to less probable reward when the reward is signaled. A recently quantified model, the Signal for Good News (SiGN) model, assumes that in the context of uncertainty, signals for a reduced delay to reward reinforce choice. The SiGN model provides an excellent fit to previous results from pigeons and the current studies are the first to test a priori quantitative predictions. Pigeons chose between a suboptimal alternative that led to signaled 20% food and an optimal alternative that led to 50% food. The duration of the choice period was manipulated across conditions in two experiments. Pigeons strongly preferred the suboptimal alternative at the shorter durations and strongly preferred the optimal alternative at the longer durations. The results from both experiments fit well with predictions from the SiGN model and show that altering the duration of the choice period has a dramatic effect in that it changes which of the two options pigeons prefer. More generally, these results suggest that the relative value of options is not fixed, but instead depends on the temporal context.