bluuebunny/crossref_metadata_2025_split huggingface dataset:
PA28γ induces dendritic cell maturation and activates T‐cell immune responses in oral lichen planus
Authors: Wang Yimei , Zhang Qiyue , Deng Xiaoting , Wang Ying , Tian Xin , Zhang Shiyu , Shen Yingqiang , Zhou Xikun , Zeng Xin , Chen Qianming , Jiang Lu , Li Jing 
Published: May 2024

AbstractOral lichen planus (OLP) is a common chronic inflammatory disease of the oral mucosa, the mechanism of its inflammatory progression has not yet been fully elucidated. PA28γ plays a significant role in a variety of immune‐related diseases. However, the exact role of PA28γ in the pathogenesis of OLP remains unclear. Here, we demonstrated that PA28γ is overexpressed in epithelial cells and inflammatory cells of OLP tissues but has no significant relationship with OLP subtypes. Functionally, keratinocytes with high PA28γ expression could induce dendritic cell (DC) maturation and promote the T‐cell differentiation into Th1 cells in response to the immune response. In addition, we found that a high level of PA28γ expression is associated with high numbers of infiltrating mature DCs and activated T‐cells in OLP tissues. Mechanistically, keratinocytes with high PA28γ expression could promote the secretion of C–C motif chemokine (CCL)5, blocking CCL5 or/and its receptor CD44 could inhibit the induction of T‐cell differentiation by keratinocytes with high PA28γ expression. In conclusion, we reveal that keratinocytes with high expression of PA28γ in OLP can induce DC maturation and promote T‐cell differentiation through the CCL5‐CD44 pathway, providing previously unidentified mechanistic insights into the mechanism of inflammatory progression in OLP.
The Quality in Quality of Life in Parkinson's Disease: A Qualitative Meta‐Synthesis
Authors: van Munster Marlena , Pedrosa Anna J. , Künkler Carolin , Pedrosa David J. 
Published: May 2024

AbstractBackgroundQuality of life (QoL) is known to be impaired in people with Parkinson's disease (PwPD). Not surprisingly, a considerable effort of health interventions is aimed at maintaining or improving QoL. Yet, little is known about its determinants from a PwPD perspective to inform person‐centered health care interventions.ObjectivesThis systematic review aims to overcome this information gap by synthesizing existing evidence on factors associated with PwPD’ self‐perceived QoL.MethodsWe searched six electronic databases (MEDLINE, EMBASE, PsycINFO, CINAHL, Web of Science, Cochrane Library) from inception to January 2022 for eligible qualitative studies of QoL in PwPD, supplemented by citation tracking and hand searching. Study quality was assessed using the QualSyst tool. In order to characterize the determinants of QoL in PwPD, we conducted a qualitative meta‐synthesis.ResultsOur analysis revealed a wide range of facilitators and barriers to QoL relating to seven overarching themes: Illness experience, health care, everyday life, social life, identity, spirituality/religion, and environment.ConclusionsOur systematic review reinforces the impact of symptom experience on PwPD's QoL. However, it also highlights the need to consider the non‐physical dimensions of PD when assessing patients’ QoL. It is therefore essential that health care professionals acknowledge the psychological, social and spiritual repercussions of PD and endeavor to respond to these concerns through a comprehensive and patient‐centered strategy. Further research is needed to gain a deeper understanding of these facets of PD and to formulate successful interventions aimed at improving the QoL of PwPD.
Breast reconstruction using a superficial inferior epigastric artery flap with pedicle elongation via an arteriovenous loop: A case report
Authors: Otsuka Wataru , Karakawa Ryo , Yoshimatsu Hidehiko , Yano Tomoyuki 
Published: May 2024

AbstractSuperficial inferior epigastric artery (SIEA) flap is often chosen to minimize postoperative complications such as abdominal pain and bulging. However, drawbacks, including a small diameter and a short pedicle, pose challenges in anastomosing or creating the lower pole of the breast. Here, we report a case of breast reconstruction using an SIEA flap with pedicle elongation via an arteriovenous loop (AV‐loop) using a contralateral superficial inferior epigastric vein (SIEV) graft. A 49‐year‐old woman underwent a left total mastectomy with the primary insertion of a tissue expander. Breast reconstruction using an SIEA flap with pedicle elongation was planned. The running pattern, pedicle length, and diameter of bilateral SIEA/SIEV and superficial circumflex iliac artery and vein (SCIA/SCIV) were evaluated preoperatively using a 48‐MHz probe of ultra‐high‐frequency ultrasonography (Vevo MD ultrasound device, Fujifilm Visual Sonics, Amsterdam, the Netherlands). During the flap harvesting, the contralateral SIEV graft was harvested to create an AV‐loop for pedicle elongation. The 9 cm graft was anastomosed to the left internal mammary artery and vein (IMA/IMV). After the flap elevation, the created AV‐loop was divided at the midpoint and anastomosed to the pedicle of the SIEA flap. The SIEA flap, extended with a SIEV AV‐loop, facilitated the augmentation of the lower pole of the breast without the risk of pedicle kinking and pulling. The postoperative course was uneventful, and the patient was discharged on postoperative day 7. The prolonged pedicle length via an AV‐loop prevents the pedicle kinking and allows for positioning the flap more freely, resulting in an aesthetically good breast contour by filling in the lower pole. The precise preoperative evaluation of the vessels using ultra‐high‐frequency ultrasonography facilitated meticulous planning. In cases where surgeons aim to minimize intraoperative and postoperative complications associated with other abdominal free flaps, this method may be considered a viable and promising option.
Oral and topical analgesia in pediatric electrodiagnostic studies
Authors: Aziz Bisma , Hameed Sajid , Hakeem Haris , Rehman Fazal ur , Malik Marib Ghulam Rasool , Sattar Saadia , Baig Pinin , Zuberi Safoora Ibraheem , Khan Sara 
Published: May 2024

AbstractIntroduction/AimsElectrodiagnostic examinations, such as nerve conduction studies (NCS) and needle electromyography (EMG), are perceived as painful by children and their parents/guardians. Methods to reduce peri‐procedural pain improve compliance and have neurocognitive and neuropsychiatric benefits. This study aimed to assess the efficacy of combined oral and topical analgesics (COTA), oral analgesics (OA), and placebo in reducing pain during NCS/EMG in children.MethodsWe performed a double‐blind, randomized, placebo‐controlled trial on children presenting to our neurophysiology lab. Patients were stratified into two age groups (6M–6Y and 7Y–18Y) and randomized into three arms: COTA, OA, and placebo. Pain scores post‐NCS/EMG were assessed using the Modified Behavioral Pain Scale (MBPS) and Faces Pain Scale‐Revised (FPS‐R).ResultsOne hundred thirteen participants were enrolled. A comparison of participants from both age groups combined revealed no significant differences in guardian FPS‐R scores across all arms for NCS and EMG. A significant difference in the distribution of post‐NCS FPS‐R score severities in children aged 7Y–18Y was noted between OA and placebo (p = .007). EMG was more painful than NCS across all arms (p < .05). In children aged 6M–6Y undergoing at least 10 muscle samplings during EMG, those receiving COTA had significantly lower pain scores (p = .014).DiscussionThis study reveals the complexity of pediatric pain perception during NCS/EMG and highlights that other methods to reduce experienced pain are required. Our findings suggest that procedural characteristics, such as number of muscles sampled, may influence the effectiveness of analgesia and serve as a foundation for future research aimed at optimizing pain management strategies.
Applications of ChatGPT in Otolaryngology–Head Neck Surgery: A State of the Art Review
Authors: Lechien Jérôme R. , Rameau Anais 
Published: May 2024

AbstractObjectiveTo review the current literature on the application, accuracy, and performance of Chatbot Generative Pre‐Trained Transformer (ChatGPT) in Otolaryngology–Head and Neck Surgery.Data SourcesPubMED, Cochrane Library, and Scopus.Review MethodsA comprehensive review of the literature on the applications of ChatGPT in otolaryngology was conducted according to Preferred Reporting Items for Systematic Reviews and Meta‐analyses statement.ConclusionsChatGPT provides imperfect patient information or general knowledge related to diseases found in Otolaryngology–Head and Neck Surgery. In clinical practice, despite suboptimal performance, studies reported that the model is more accurate in providing diagnoses, than in suggesting the most adequate additional examinations and treatments related to clinical vignettes or real clinical cases. ChatGPT has been used as an adjunct tool to improve scientific reports (referencing, spelling correction), to elaborate study protocols, or to take student or resident exams reporting several levels of accuracy. The stability of ChatGPT responses throughout repeated questions appeared high but many studies reported some hallucination events, particularly in providing scientific references.Implications for PracticeTo date, most applications of ChatGPT are limited in generating disease or treatment information, and in the improvement of the management of clinical cases. The lack of comparison of ChatGPT performance with other large language models is the main limitation of the current research. Its ability to analyze clinical images has not yet been investigated in otolaryngology although upper airway tract or ear images are an important step in the diagnosis of most common ear, nose, and throat conditions. This review may help otolaryngologists to conceive new applications in further research.
The Australian New Zealand Consortium in Children, Adolescents, and Young Adults Oncofertility action plan
Authors: Lau Lei Shong , Allingham Catherine , Anazodo Antoinette , Sullivan Michael , Peate Michelle , Hunter Sarah , Stern Catharyn , Ryan Anne Louise , Super Leanne , Orme Lisa M. , McCarthy Maria , Gook Debra , Lewin Jeremy , Marino Jennifer , Ryan Jessica , Downie Peter , Manudhane Rebecca , Winstanley Mark , Pettit Tristan , Lantsberg Daniel , Irving Helen , Reid Sally , Heath John A. , Kabalan‐Baeza Paola , Wanaguru Dylan , Moore Lyndal , Gillam Lynn , Zacharin Margaret , Assis Michael , Rozen Genia , Hunter Tamara , Julania Shital , Sharwood Erin , Ameratunga Devini , Jayasinghe Yasmin ,   for The ANZCO Clinical Trial Network
Published: May 2024

AbstractInternational and national oncofertility networks, including the US‐led Oncofertility Consortium, FertiProtekt, and the Danish Network, have played pivotal roles in advancing the discipline of oncofertility over the last decade. Many other countries lack a shared approach to pediatric oncofertility health service delivery. This study aims to describe baseline oncofertility practices at Australian New Zealand Children's Haematology/Oncology Group centers in 2019–2021, describe binational priorities for care, and propose a 5‐year action plan for best practice to be implemented by the newly formed Australian New Zealand Consortium in Children, Adolescents, and Young Adults (CAYA) Oncofertility (ANZCO).
Thermoplastic polyimide with good comprehensive performance based on carbazole groups and short flexible linkages
Authors: Du Qi‐Yuan , Chen Wei‐Peng , Guo Hao , Wang Zhi , Zhao Li , Zhu Yongxiang , Tan Wan‐Yi , Min Yonggang , Liu Yidong 
Published: May 2024

AbstractThermoplastic polyimides (TPIs) can meet the requirements of advanced electronic packaging such as flexible copper clad laminate (FCCL) applied under extreme conditions, attributed to their excellent thermal stability, mechanical properties, electrical insulation and chemical resistance. With the increasing demands for electronic devices, such as applications in high‐frequency communication, it is highly desirable to develop high‐performance TPI with good thermoplasticity, thermal stability, mechanical properties and dielectric properties. However, there is a trade‐off between thermoplasticity and other properties. Herein, we introduce an effective strategy to afford TPIs with good performance by copolymerization of a diamine monomer consisted of a coplanar aromatic carbazole group and a short flexible linkage methylene group. On the one hand, short flexible linkages help improve the flexibility of polymer chains and are not too much to enable small‐scale molecular motions below Tg. On the other hand, coplanar aromatic donor groups benefit to strong charge transfer complex (CTC) interaction and π‐π stacking interaction. Based on this strategy, the resultant TPI possesses good thermoplasticity with a proper Tg of 348 °C. Meanwhile, it preserves a low coefficient thermal expansion of 48 ppm K−1, low dielectric constant/dielectric loss factor of 3.27/0.0073 at 10 GHz, and tensile strength of ca. 78 MPa.
Herbicide safener isoxadifen‐ethyl associated with increased Goss's wilt severity in corn (Zea mays)
Authors: Haugrud Nathan H , Friskop Andrew , Ikley Joseph T 
Published: May 2024

AbstractBACKGROUNDGoss's bacterial wilt and leaf blight (Goss's wilt), caused by the bacterium Clavibacter nebraskensis, is a corn disease that has been a top ten yield‐reducing disease in North America in the past 15 years. Isoxadifen‐ethyl is an herbicide safener that effectively increases cytochrome P450 activity in corn which enhances a plant's metabolism of herbicide molecules. Recent research found a potential link between isoxadifen‐ethyl and increased Goss's wilt severity.RESULTSThe application of isoxadifen‐ethyl increased (P = 0.014–0.046) area under disease progress curve (AUDPC) by 19%, 7%, and 9% at three environments, independent of accompanying herbicide or herbicide application timing. However, no significant differences in incidence of systemic wilt or corn grain yield occurred among treatments at any environment.CONCLUSIONThese data provide evidence for an association between isoxadifen‐ethyl safener and Goss's wilt in corn. The reason for this association is unknown, but the safener may affect plant or pathogen physiological mechanisms. While the increased disease severity did not result in decreased grain yield in these experiments, an increase in pathogen inoculum due to higher disease severity could influence Goss' wilt epidemics in future years. © 2024 Society of Chemical Industry.
Saponin monomers: Potential candidates for the treatment of type 2 diabetes mellitus and its complications
Authors: Zhang Lvzhuo , He Shifeng , Liu Lian , Huang Jiangrong 
Published: May 2024

AbstractType 2 diabetes mellitus (T2DM), a metabolic disease with persistent hyperglycemia primarily caused by insulin resistance (IR), has become one of the most serious health challenges of the 21st century, with considerable economic and societal implications worldwide. Considering the inevitable side effects of conventional antidiabetic drugs, natural ingredients exhibit promising therapeutic efficacy and can serve as safer and more cost‐effective alternatives for the management of T2DM. Saponins are a structurally diverse class of amphiphilic compounds widely distributed in many popular herbal medicinal plants, some animals, and marine organisms. There are many saponin monomers, such as ginsenoside compound K, ginsenoside Rb1, ginsenoside Rg1, astragaloside IV, glycyrrhizin, and diosgenin, showing great efficacy in the treatment of T2DM and its complications in vivo and in vitro. However, although the mechanisms of action of saponin monomers at the animal and cell levels have been gradually elucidated, there is a lack of clinical data, which hinders the development of saponin‐based antidiabetic drugs. Herein, the main factors/pathways associated with T2DM and the comprehensive underlying mechanisms and potential applications of these saponin monomers in the management of T2DM and its complications are reviewed and discussed, aiming to provide fundamental data for future high‐quality clinical studies and trials.
Effective management of lung spindle cell carcinoma with ipilimumab, nivolumab, carboplatin, and paclitaxel, demonstrating efficacy in brain metastases treatment
Authors: Noguchi Susumu , Okamoto Atsushi , Nohara Jun , Ishitoko Manabu , Watanabe Toshiki , Nakamura Takaya 
Published: May 2024

AbstractA 76‐year‐old woman with cT1bN2M1b stage IVA spindle cell carcinoma of the right lower lobe of the lung, no driver gene mutation, and programmed death ligand 1 < 1%, was started on ipilimumab+nivolumab+carboplatin+paclitaxel. After two courses, the patient initiated maintenance therapy with ipilimumab+nivolumab. New multiple brain metastases were observed during treatment but resolved with continued treatment. We report a unique case of spindle cell carcinoma treated with ipilimumab+nivolumab+carboplatin+paclitaxel that resulted in long‐term response and resolution of new brain metastasis.
Study on Catalytic Activity of Synthetic Cobalt, Nickel and Copper Complexes due to Preferred Structures Determined by X‐Ray Crystallography for Methyl Methacrylate Polymerization
Authors: Zheng Chengyu , Ma Xueqiong , Su Biyun , Sun Huizhu , Ding Liqin 
Published: May 2024

AbstractWe have designed and synthesized two novel pyridyl‐quinoxaline ligands, L1 and L2, as well as twelve cobalt, nickel, and copper complexes, 1–6 and 1 a–6 a. Unexpectedly, high regularities in the synthesis of both ligands and complexes were found. Further X‐ray diffraction analyses revealed that the two ligands had similar geometrical configurations, and the structures of twelve complexes were regularly divided into two categories: binuclear and mononuclear, which would be beneficial for elucidating structure‐activity relationships of metal catalysts. In addition, the experimental results showed significant variations in the catalytic performance of methyl methacrylate polymerization with different catalysts. Under the optimum reaction conditions, the mononuclear copper complex 3 a displayed a remarkably high catalytic activity of 2.76×105 g ⋅ mol−1 h−1, generating Poly(methyl methacrylate) with molecular weight of Mn=8.55×105 g ⋅ mol−1 and molecular weight distribution of Đ=1.67.This outcome suggested that copper had the potential to serve as a promising catalytic metal center.
Advanced Pyrene Copolymer/rGO Hydrogels for Efficient Congo Red Removal from Aqueous Systems
Authors: Ahmed Soleen S. , Alwattar Aula A. , Ismael Shireen O. , Zaki Elsayed , Hussein Modather , Casson Alexander J. , Quayle Peter , Haddad Athir M. 
Published: May 2024

AbstractThis study investigates the use of hydrogel semi‐interpenetrating polymer networks (semi IPN) as efficient adsorbents for removing the dye congo red (CR) from aqueous solutions. Specifically, three hydrogel semi IPN, namely AH0–AH2, were synthesized through redox polymerization of acrylamide, polyethylenimine, polyhydroxylethylmethacrylate and (pyren‐1‐yl)methyl methacrylate/2‐acrylamido‐2‐methylpropane‐1‐sulfonic acid copolymer (pyrene−AMPS) using a reduced graphene oxide (RGO)‐N,N’‐methylene‐bis(acrylamide) (MBA)‐based crosslinker (GABC). Results indicated that these hydrogels were efficient in removing CR at pH 6.73, with the adsorption behaviour conforming to the Langmuir isotherm. This suggests a monolayer adsorption pattern, indicating a chemical nature. Thermodynamic analysis supports the practical feasibility of this process. The negative Gibbs free energy of adsorption (ΔG̊) indicates that adsorption is spontaneous and favorable. Conversely, the positive standard entropy of adsorption (ΔS̊) suggests an increase in molecular randomness during the process. Additionally, the standard enthalpy change (ΔH̊) suggests an endothermic activation energy for the binding process. Response Surface Methodology (RSM), utilizing four variables was employed to optimize the removal of CR. The model demonstrated high R2‐values and strong agreement between experimental and projected results, affirming its reliability. AH1 and AH2 showed significant efficacy in removing CR dye from aqueous solutions, underscoring their potential application in wastewater remediation.
Amyloid Nanofibril‐Assisted Spray Drying of Crumpled Supraparticles
Authors: Kämäräinen Tero , Nakayama Yuzuki , Uchiyama Hiromasa , Tozuka Yuichi , Kadota Kazunori 
Published: May 2024

AbstractNanofibrils are known to improve the cohesion of supraparticle (SP) assemblies. However, tailoring the morphology of SPs using nanofibrillar additives is not well developed. Herein, β‐lactoglobulin amyloid nanofibrils (ANFs) are investigated as means to impart morphological control over the assembly process of spray‐dried SPs composed of 10–100 nm silica nanoparticles (SiNPs). Phytoglycogen (PG) and silver nanowires (AgNWs) are used to assess the influence of building block softness and aspect ratio, respectively. The results demonstrate that ANFs promote the onset of structural arrest during the particle consolidation enabling the preparation of corrugated SP morphologies. The critical ANF loading required to induce SP corrugation increases by roughly 1 vol% for every 10‐nm increase in SiNP diameter, while the ensuing ANF network density decreases with SiNP volume fraction and increases with SiNP diameter. Results imply that ANF length starts to become influential when it approaches the SiNP diameter. ANFs display a reduced effectiveness in altering soft PG SP morphology compared with hard SiNPs of comparable size. In SiNP–AgNW SPs, ANFs induce a toroid‐to‐corrugated morphology transformation for sufficiently large SPs and small SiNPs. The results illustrate that ANFs are effective additives for the morphological engineering of spray‐dried SPs important for numerous applications.
A Multi‐Interface Structure of Graphdiyne/Cobalt Oxides for Chlorine Production
Authors: Liu Huimin , Qi Lu , Chen Zhaoyang , Zhao Shuya , Luan Xiaoyu , Yan Jiayu , Zheng Zhiqiang , Bu Fanle , Xue Yurui , Li Yuliang 
Published: May 2024

AbstractA challenge facing the chlor‐alkali process is the lack of electrocatalyst with high activity and selectivity for the efficient industrial production of chlorine. Herein the authors report a new electrocatalyst that can generate multi‐interface structure by in situ growth of graphdiyne on the surface of cobalt oxides (GDY/Co3O4), which shows great potential in highly selective and efficient chlorine production. This result is due to the strong electron transfer and high density charge transport between GDY and Co3O4 and the interconversion of the mixed valence states of the Co atoms itself. These intrinsic characteristics efficiently enhance the conductivity of the catalyst, facilitate the reaction kinetics, and improve the overall catalytic selectivity and activity. Besides, the protective effect of the formed GDY layer is remarkable endowing the catalyst with excellent stability. The catalyst can selectively produce chlorine in low‐concentration of NaCl aqueous solution at room temperature and pressure with the highest Faraday efficiency of 80.67% and an active chlorine yield rate of 184.40 mg h−1 cm−2, as well as superior long‐term stability.