bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of aromatic sulfonate derivative on the crystallization, thermal resistance, and hydrolytic properties of poly(lactic acid)
Authors: Wei Deyu , Wang Guoqiang , Lou Ziheng , Zhao Yan , Zhang Huiliang 
Published: May 2024

AbstractThe thermal, crystallization kinetics and hydrolysis properties of poly(lactic acid)‐based blends containing different concentrations of 5‐dimethylthioisosulfate salts (LAK) were systematically investigated and compared with those of poly(lactic acid) (PLA). PLA/LAK blends were prepared by melt blending method‐using LAK as a nucleating agent of PLA. During the isothermal crystallization process, the morphology of PLA crystal in the neat PLA and PLA/LAK blends showed spherical crystals. With an increase in the concentration of LAK, the nucleating density of the PLA spherulites increased and the size of the PLA spherulites decreased. Differential scanning calorimetry indicates that after the addition of LAK, both the crystallinity and crystallization rate of PLA have been enhanced. In situ X‐ray diffraction analysis also shows that the sample exhibits the same crystal structure as neat PLA and continues to strengthen, indicating that LAK enhances the crystallization properties of PLA. Moreover, the crystallinity of PLA increased and crystal size of PLA decreased with the increase in the LAK content. The Vicat softening temperatures of PLA/LAK blends increased, so the heat resistance improved. Through hydrolysis testing under identical conditions, the PLA/LAK blends exhibits better hydrolytic stability.
Patient‐ and parent‐reported diagnostic delay in children with central nervous system tumors in Denmark
Authors: Weile Kathrine Synne , Helligsoe Anne Sophie Lind , von Holstein Sarah Linea , Winther Jeanette Falck , Mathiasen René , Hasle Henrik , Henriksen Louise Tram 
Published: May 2024

AbstractBackgroundDiagnostic delays in childhood tumors of the central nervous system (CNS) pose a significant challenge. The aim of this study was to map diagnostic delay and presenting symptoms in Denmark.MethodsThe study was a retrospective questionnaire study, mapping delay and symptoms in pediatric patients (0–17 years), diagnosed with a CNS tumor from 2015 to 2019. Descriptive analysis was performed to measure delay in days, reported as total diagnostic interval (TDI), patient interval (PI), and diagnostic interval (DI). Analysis of symptoms, contacts to healthcare professionals, and socioeconomic status was also performed.ResultsWe included 89 patients (median age 7.0 years, 54% male). The TDI was median of 106 days (range: 0–2694 days). Low‐grade tumors had longer TDI than high‐grade tumors (125 vs. 43 days; p ≤ .02). Patients aged 15–17 displayed the longest TDI (median 665 days). Number of symptoms at onset were inversely associated with longer TDI in patients presenting one symptom (247 days) and patients presenting two to three (110 days) or greater than three complaints (66 days). PI was not associated with sex (p = .14), tumor grade (p = .63), location (p = .32), or socioeconomic status (p = .82). Most frequent single complaint at onset was headache (19%), most frequent combination of symptoms was headache and vomiting (60%).ConclusionWe found TDIs longer than reported in contemporary publications. TDI was longer in patients with low‐grade tumors and only few symptoms at the time of onset. The findings support the crucial need of awareness and improved diagnostic tools to recognize and interpret symptoms to promote timely diagnosis.
Unpacking Behaviours: A Literature Study and Research Agenda on Consumer Behaviour in Packaging‐Free Systems
Authors: Jiménez Romanillos Elena , Williams Helén , Wever Renee 
Published: May 2024

ABSTRACTIn an era where food packaging plays a dual role in both reducing food waste and contributing to global packaging waste, this study presents an analysis of packaging‐free systems. As governments and organizations attempt to address the environmental impact of single‐use packaging, packaging‐free alternatives have emerged as a promising solution. However, there is a need for a comprehensive assessment of environmental sustainability and its alignment with consumer behaviours and preferences in this growing type of grocery system. Considering this need, this study employs an integrative literature review process, selecting 51 research articles. This selection was classified into three principal areas: the characteristics of packaging‐free services, the dynamics of consumer behaviour and patterns from a household perspective. This review evaluates the effectiveness of packaging‐free systems, exploring the factors that drive consumer adoption, the obstacles to transitioning and the relevance of theoretical frameworks like the theory of planned behaviour (TPB) and practice theory (PT) in understanding and assessing the sustainability of these alternatives. The result of this study is the identification of significant research gaps and opportunities, leading to a comprehensive research agenda. This agenda emphasizes the need for a more refined understanding of consumer classifications that extend beyond standard demographic metrics, delving into aspects like household structures, dietary preferences and regional variations. The study highlights the limited scope of existing literature by advocating for a holistic grocery analysis that blends packaging‐free and conventional shopping practices to understand more realistic grocery scenarios, as not all products are available in packaging‐free alternatives. It also underscores the importance of integrating environmental assessments with consumer behaviour studies to see the sustainability of the systems beyond reusable containers. Additionally, this research sheds light on the relatively unexplored area of online packaging‐free services, questioning the sustainable implication of incorporating online alternatives in grocery practices, and suggests a broader application of theoretical frameworks, including activity theory (AT) as a new perspective to achieve a new understanding of these systems. Lastly, contributing to the overall understanding of packaging‐free systems, the study concludes with a SWOT analysis that briefly identifies strengths in environmental sustainability and consumer awareness, balanced against weaknesses like data gaps and complex consumer decision‐making processes.
Probing Collins Conjecture with correlation energies and entanglement entropies for the ground and excited states in the helium iso‐electronic sequence
Authors: Lin Yen‐Chang , Ho Yew Kam 
Published: May 2024

AbstractIn the present work, we present an investigation of Collins Conjecture, a hypothesis made by D. M. Collins in 1993 relating correlation energy and entanglement entropy, by calculating the ground state and singly‐excited triplet‐spin 1s2s 3S and 1s3s 3S state energies of the helium iso‐electronic sequence, with Z = 2–15. By using extensive orthonormal configuration interaction (CI) type wave functions with B‐Spline basis up to about 6000 terms, linear entropy and von Neumann entropy for the abovementioned atomic systems are determined. Together with the Hartree‐Fock energies obtained following a self‐consistent field theory, we have found that there exist linearly proportionalities between the renormalized correlation energies and entanglement entropies of both linear and von Neumann, showing a support for Collins Conjecture applicable to the ground and singly‐excited triplet‐spin states in the helium sequence, for a range of finite Z‐values.
QSPR analysis for certain bio‐molecular architectures
Authors: Renai P. Noah Antony Daniel , Roy S. , Govardhan S. 
Published: May 2024

AbstractFlavonoids are known for its mechanism of antioxidant property which can prevent DNA damage. These natural products' anticancer and antiviral properties are linked to their mechanism of action. Various examinations reveals that, there will be a adjacent relationship between the molecular structure and their physicochemical properties such as boiling point, melting point, entropy, and so forth. In this work we have presented the physicochemical analysis and determination of ‐electron energy for some bio‐molecular structures namely Erythroxylum Flavonoids, DNA (deoxyribonuclic acid), and RNA (ribonuclic acid). Additionally, the QSPR analysis of bio‐molecular structures using ten degree based topological indices are discussed to assist researchers in understanding the chemical reactions and physical properties related with them. Furthermore, we demonstrated that the indices values correlate well with the physicochemical properties of flavonoids, DNA, and RNA molecular structures from the presented regression model.
Intact quantitation of cysteine‐conjugated antibody‐drug conjugates using native mass spectrometry
Authors: Li Yihan , Wang Yuting , Shenoy Vikram M. , Niu Shuai , Jenkins Gary J. , Sarvaiya Hetal 
Published: May 2024

RationaleA common strategy for antibody‐drug conjugate (ADC) quantitation from in vivo study samples involves measurement of total antibody, conjugated ADC, and free payload concentrations using multiple reaction monitoring (MRM) mass spectrometry. This not only provides a limited picture of biotransformation but can also involve lengthy method development. Quantitation of ADCs directly at the intact protein level in native conditions using high‐resolution mass spectrometers presents the advantage of measuring exposure readout as well as monitoring the change in average drug‐to‐antibody ratio (DAR) and in vivo stability of new linker payloads with minimal method development. Furthermore, site‐specific cysteine‐conjugated ADCs often rely on non‐covalent association to retain their quaternary structure, which highlights the unique capabilities of native mass spectrometry (nMS) for intact ADC quantitation.MethodsWe developed an intact quantitation workflow involving three stages: automated affinity purification, nMS analysis, and data processing in batch fashion. The sample preparation method was modified to include only volatile ion‐pairing reagents in the buffer systems. A capillary size‐exclusion chromatography (SEC) column was coupled to a quadrupole time‐of‐flight high‐resolution mass spectrometer for high‐throughput nMS analysis. Samples from two mouse pharmacokinetic (PK) studies were analyzed using both intact quantitation workflow and the conventional MRM‐based approach.ResultsA linear dynamic range of 5–100 μg/mL was achieved using 20 μL of serum sample volume. The results of mouse in vivo PK measurement using the intact quantitation workflow and the MRM‐based approach were compared, revealing excellent method agreement.ConclusionsWe demonstrated the feasibility of utilizing nMS for the quantitation of ADCs at the intact protein level in preclinical PK studies. Our results indicate that this intact quantitation workflow can serve as an alternative generic method for high‐throughput analysis, enabling an in‐depth understanding of ADC stability and safety in vivo.
Typification of the Linnaean name Arum peregrinum (Araceae)
Authors: Iamonico Duilio 
Published: May 2024

AbstractThe typification of the Linnaean name Arum peregrinum, validly published in the first edition of Species plantarum, is discussed. In the absence of original material useful for lectotypification, a study of the various pre‐Linnaean works linked to this name, as well as an in‐depth analysis of literature, was necessary to understand its concept and designate a neotype. Tabula XXXVI in Plumier's Plantarum Americanarum, which was cited by Linnaeus in the tenth edition of Systema naturae under Arum peregrinum, is selected as neotype. Based on the typification, Arum peregrinum is synonymized with Alocasia macrorrhizos.
Modeling sub‐resolution porosity of a heterogeneous carbonate rock sample
Authors: Godoy William , Pontedeiro Elizabeth M. , Barros Rafael A. B. R. , de Vries Enno T. , Raoof Amir , van Genuchten Martinus Th. , Couto Paulo 
Published: May 2024

AbstractAccurately estimating the petrophysical properties of heterogeneous carbonate rocks across various scales poses significant challenges, particularly within the context of water and hydrocarbon reservoir studies. Digital rock analysis techniques, such as X‐ray computed microtomography and synchrotron‐light‐based imaging, are increasingly employed to study the complex pore structure of carbonate rocks. However, several technical limitations remain, notably the need to balance the volume of interest with the maximum achievable resolution, which is influenced by geometric properties of the source–detector distance in each apparatus. Typically, higher resolutions necessitate smaller sample volumes, leading to a portion of the pore structure (the sub‐resolution or unresolved porosity), that remain undetected. In this study, X‐ray microtomography is used to infer the fluid flow properties of a carbonate rock sample having a substantial fraction of porosity below the imaging resolution. The existence of unresolved porosity is verified by comparisons with nuclear magnetic resonance (NMR) data. We introduce a methodology for modeling the sub‐resolution pore structure within images by accounting for unresolved pore bodies and pore throats derived from a predetermined distribution of pore throat radii. The process identifies preferential pathways between visible pores using the shortest distance and establishes connections between these pores by allocating pore bodies and throats along these paths, while ensuring compatibility with the NMR measurements. Single‐phase flow simulations are conducted on the full volume of a selected heterogeneous rock sample by using the developed pore network model. Results are then compared with petrophysical data obtained from laboratory measurements.
From Goa to Angola: Exploring Ideas and Mechanisms in Japan’s Kaihatsu-Yunyū
Authors: Kim Soyeun 
Published: May 2024

AbstractThe chapter investigates the evolution, ideational background, and implementation mechanisms of kaihatsu-yunyū (the “develop-and-import” scheme). In exploring and historicising this little studied topic, the chapter first examines the earliest form of kaihatsu-yunyū as seen in the Goa formula first appeared in 1951. The Goa formula was essentially a long-term resource-backed credit agreement in which Japan exported the necessary capital goods and technology to India—formerly considered as part of Southeast Asia—in exchange for iron ore as repayment. The chapter then surveys kaihatsu-yunyū in the context of Japan’s economic cooperation during the 1950s and 1960s as a dual-purpose policy tool to rebuild trade relations with Southeast Asia by securing raw materials from it, and expanding exports to the region. It also examines kaihatsu-yunyū-style aid that was designed to promote trade with Southeast Asia. To conclude, the chapter briefly discusses the legacy and significance of kaihatsu-yunyū—particularly the influence of Goa on the “Aid for Trade” agenda and China's contemporary large-scale resource-for-infrastructure swap agreements under its Angola model.
Hyers–Ulam stability of integral equations with infinite delay
Authors: Dragičević Davor , Pituk Mihály 
Published: May 2024

AbstractIntegral equations with infinite delay are considered as functional equations in a Banach space. Two types of Hyers–Ulam stability criteria are established. First, it is shown that a linear autonomous equation is Hyers–Ulam stable if and only if it has no characteristic value with zero real part. Second, it is proved that the Hyers–Ulam stability of a linear autonomous equation is preserved under sufficiently small nonlinear perturbations. The proofs are based on a recently developed decomposition theory of linear integral equations with infinite delay.
Capillary contact points determine beta cell polarity, control secretion and are disrupted in the db/db mouse model of diabetes
Authors: Jevon Dillon , Cottle Louise , Hallahan Nicole , Harwood Richard , Samra Jaswinder S. , Gill Anthony J. , Loudovaris Thomas , Thomas Helen E. , Thorn Peter 
Published: May 2024

Abstract
Aims/hypothesis
Almost all beta cells contact one capillary and insulin granule fusion is targeted to this region. However, there are reports of beta cells contacting more than one capillary. We therefore set out to determine the proportion of beta cells with multiple contacts and the impact of this on cell structure and function.

Methods
We used pancreatic slices in mice and humans to better maintain cell and islet structure than in isolated islets. Cell structure was assayed using immunofluorescence and 3D confocal microscopy. Live-cell two-photon microscopy was used to map granule fusion events in response to glucose stimulation.

Results
We found that 36% and 22% of beta cells in islets from mice and humans, respectively, have separate contact with two capillaries. These contacts establish a distinct form of cell polarity with multiple basal regions. Both capillary contact points are enriched in presynaptic scaffold proteins, and both are a target for insulin granule fusion. Cells with two capillary contact points have a greater capillary contact area and secrete more, with analysis showing that, independent of the number of contact points, increased contact area is correlated with increased granule fusion. Using db/db mice as a model for type 2 diabetes, we observed changes in islet capillary organisation that significantly reduced total islet capillary surface area, and reduced area of capillary contact in single beta cells.

Conclusions/interpretation
Beta cells that contact two capillaries are a significant subpopulation of beta cells within the islet. They have a distinct form of cell polarity and both contact points are specialised for secretion. The larger capillary contact area of cells with two contact points is correlated with increased secretion. In the db/db mouse, changes in capillary structure impact beta cell capillary contact, implying that this is a new factor contributing to disease progression.

Graphical Abstract
Uncertainty in Environmental Micropollutant Modeling
Authors: Ahkola Heidi , Kotamäki Niina , Siivola Eero , Tiira Jussi , Imoscopi Stefano , Riva Matteo , Tezel Ulas , Juntunen Janne 
Published: May 2024

AbstractWater pollution policies have been enacted across the globe to minimize the environmental risks posed by micropollutants (MPs). For regulative institutions to be able to ensure the realization of environmental objectives, they need information on the environmental fate of MPs. Furthermore, there is an urgent need to further improve environmental decision-making, which heavily relies on scientific data. Use of mathematical and computational modeling in environmental permit processes for water construction activities has increased. Uncertainty of input data considers several steps from sampling and analysis to physico-chemical characteristics of MP. Machine learning (ML) methods are an emerging technique in this field. ML techniques might become more crucial for MP modeling as the amount of data is constantly increasing and the emerging new ML approaches and applications are developed. It seems that both modeling strategies, traditional and ML, use quite similar methods to obtain uncertainties. Process based models cannot consider all known and relevant processes, making the comprehensive estimation of uncertainty challenging. Problems in a comprehensive uncertainty analysis within ML approach are even greater. For both approaches generic and common method seems to be more useful in a practice than those emerging from ab initio. The implementation of the modeling results, including uncertainty and the precautionary principle, should be researched more deeply to achieve a reliable estimation of the effect of an action on the chemical and ecological status of an environment without underestimating or overestimating the risk. The prevailing uncertainties need to be identified and acknowledged and if possible, reduced. This paper provides an overview of different aspects that concern the topic of uncertainty in MP modeling.
Twenty-Four-Month Safety and Effectiveness of TCD-17187 Drug-Coated Balloon for Treatment of Atherosclerotic Lesions in Superficial Femoral and Proximal Popliteal Artery
Authors: Soga Yoshimitsu , Iida Osamu , Seki Shu-Ichi , Kawasaki Daizo , Anzai Hitoshi , Ando Hiroshi , Nakama Tatsuya , Shinozaki Norihiko , Kozuki Amane , Ishihara Masaharu , Urasawa Kazushi , Toi Satoru , Tsujita Hiroaki , Tobita Kazuki , Ogata Kenji , Horie Kazunori , Hayakawa Naoki , Mori Shinsuke , Fujihara Masahiko , Ohki Takao , Yuba Kenichiro , Mano Toshiaki , Ando Kenji , Nakamura Masato ,   The TCD-17187 Japan Investigators, Ikari Yuji , Shinke Toshiro , Saito Shigeru , Shibata Yoshisato , Kishi Koichi 
Published: May 2024

Abstract
Purpose
In the present trial, the 24-month safety and effectiveness of the TCD-17187 drug-coated balloon (DCB) for the treatment of atherosclerotic lesions in the superficial femoral artery (SFA) and proximal popliteal artery (PA) were evaluated in Japanese patients.

Methods
This was a prospective, multicenter, core laboratory-adjudicated, single-arm trial. From 2019 to 2020, 121 patients with symptomatic peripheral artery disease were enrolled. The primary effectiveness outcome measure was primary patency. The safety outcome measure was the major adverse event (MAE) rate.

Results
Age was 74.5 ± 7.3 years, and diabetes mellitus was present in 67.5%. Lesion length and reference vessel diameter (RVD) were 106.0 ± 52.6 mm and 5.2 ± 0.8 mm, respectively. Chronic total occlusion (CTO) and bilateral calcification rate (Grade 3 and 4 by peripheral arterial calcium scoring system (PACSS)) were 17.5% and 50.8%, respectively. The 24-month primary patency rate by duplex ultrasound was 71.3%, while freedom from clinically driven target lesion revascularization (CD-TLR) was 87.0%. The MAE rate was 13.2% and all events consisted of CD-TLR. There were no instances of device- or procedure-related deaths major amputations throughout the 24 months. Multivariate Cox proportional hazards regression analysis revealed significant differences associated with loss of primary patency in the following characteristics: CTO, restenotic lesion and RVD.

Conclusion
This trial confirmed the safety and effectiveness of TCD-17187 DCB for atherosclerotic lesions of the SFA and/or proximal PA for up to 24 months.

Level of Evidence
Level 3, Cohort study.
Clinical Trial Registration: URL: https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function=brows&action=brows&recptno=R000038612&type=summary&language=J:Registration ID: UMIN000034122. Registration Date: September 13, 2018.