bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geographic and Temporal Patterns in Biologic Prescriptions for Inflammatory Bowel Diseases in the Public Healthcare System in Brazil: An Ecological Study
Authors: de Castro Caroline Tianeze , dos Santos Natividade Marcio , Pereira Marcos , Miranda Samilly Silva , Aragão Erika , de Souza Teles Santos Carlos Antonio , dos Santos Djanilson Barbosa 
Published: February 2025

ABSTRACTPurposeTo analyze the geographic and temporal patterns of biologic prescriptions for inflammatory bowel disease (IBD) in Brazil's public national unified health system (SUS).MethodsThis ecological study used data from patients with IBD in the SUS Outpatient Information System between 2008 and 2022. Prais‐Winsten regression was used to estimate the trends in prescription rate of biologics. For geographic analysis, average prescription rate of biologics was calculated by state for three periods: 2008–2012, 2013–2017, and 2018–2022. Global Moran's index (GMI) and local indicators of spatial autocorrelation (LISA) were used to assess spatial autocorrelation and identify spatial clusters of biologic prescriptions, respectively.ResultsThe prescription rate of biologics increased from 3.0% to 16.7%. Infliximab was the most prescribed drug from 2008 to 2012 (3.0%–4.2%), and adalimumab was the most widely prescribed drug from 2013 to 2022 (4.3%–9.1%). Higher prescription rates of biologics were observed in patients with Crohn's disease than in those with ulcerative colitis (40.5% vs. 3.2%). Biologics were primarily prescribed in the Southeast and South; however, the central‐western and northern regions showed greater changes in prescription rates over time. There were increased clusters of high biologic prescriptions across the three evaluated periods.ConclusionsThe increase in biologic prescriptions over time may be attributed to their enhanced efficacy in inducing and maintaining IBD remission. Biologic prescriptions in Brazil are experiencing temporal and geographical changes, indicating that disparities in drug prescriptions may decrease with universal, equitable healthcare access, despite administrative challenges in obtaining these medications through SUS.
Opioid Use After Hip Fracture and Subsequent Fracture Outcomes: A Self‐Controlled Case Series Design
Authors: Cupp Meghan A. , Hayes Kaleen N. , Berry Sarah D. , Beaudoin Francesca L. , Riester Melissa R. , Joshi Richa , Zullo Andrew R. 
Published: February 2025

ABSTRACTPurposeHip fractures in older adults cause severe pain that often necessitates opioid use. However, opioids may trigger falls that result in subsequent fractures. Studies examining the effects of opioids on subsequent fractures are often limited by unmeasured confounding between opioid‐treated and untreated persons. To overcome this limitation, we used a self‐controlled case series (SCCS) design to investigate subsequent fracture risk during periods of opioid use after hip fracture.MethodsThe retrospective cohort included Medicare beneficiaries aged > 65 years who had a subsequent hip fracture within one year after an incident hip fracture (2012–2018). We estimated the risk of subsequent hip fracture in three exposure intervals according to the duration of opioid exposure: (1) The first 0–14 days of opioid exposure, (2) days 15–42 of exposure, and (3) opioid use beyond 42 days. We employed several approaches to modify the SCCS design to be more robust to assumptions, including adjustment for event‐dependent exposures.ResultsThe rate of subsequent fracture was greatest during opioid use across a variety of approaches. The effect within the first 14 days after initiating opioids was robust to SCCS design choices, ranging from IRR 1.12 (95%CLs 0.98, 1.28) to IRR 1.77 (95%CLs 1.52, 2.07). The effect of extended opioid use (> 42 days) ranged from IRR 2.49 (95%CLs 1.95, 3.18) to IRR 4.08 (95%CLs 3.06, 5.46).ConclusionsAnalyses indicate a consistent increased risk of subsequent fracture associated with opioid use and demonstrate the importance that SCCS assumptions must be carefully investigated for real‐world applications.
The impact of functionalized β‐CD surface‐coated ZnO@Mg–Al LDH on the properties of double network PVA hydrogel nanocomposites
Authors: Hajibeygi Mohsen , Kazemi Najmeh 
Published: February 2025

AbstractDouble network polyvinyl alcohol (PVA) hydrogel nanocomposites were prepared through interpenetrating of an amide‐sulfonic acid functionalized hydrogel into the PVA matrix, which was reinforced by carboxylated β‐cyclodextrin (CCD) modified ZnO@Mg–Al LDH (CZnL). CZnL was prepared by the reconstructing calcined LDH, supported by ZnO nanoparticles in the presence of CCD. XRD, FE‐SEM, and TEM results indicated the successful self‐assembled and intercalated LDH in the presence of surface‐coated ZnO nanoparticles. The water content measurements indicated the significant impact of the double network hydrogel on the absorption of water molecules. The TGA result of the PVA sample loaded with 2 wt% of hydrogel exhibited highest thermal stability, suggesting a greater impact of the hydrogel compared to the nanohybrid filler. The MCC and LOI results indicated a desirable synergistic effect of CZnL and hydrogel in enhancing the flame retardancy of the PVA films. The PVA sample loaded with 2.5 wt% of CZnL and 2.5 wt% hydrogel exhibited 171 W·g−1 and 176 kJ·g−1 reductions in pHRR and HRC values, respectively, compared to neat PVA. The elongation at break and tensile strength of the mentioned sample increased from 17.68% to 21.25% and 88.30 to 96.86 MPa, respectively, compared to neat PVA.Highlights
Preparation a nanohybrid including nanosized ZnO installed on the calcined LDH.
Synthesis of carboxylated β‐cyclodextrin for modification of ZnO@LDH.
Preparation of double network PVA/CD modified ZnO@LDH hydrogel nanocomposites.
The effect investigation of hydrogel and modified nanohybrid on the PVA properties.
Improved properties were observed in the PVA nanocomposites.
Ultraviolet aging characteristics of waste laser printed paper reinforced high‐density polyethylene (HDPE) based composite materials
Authors: Zhang Xiaolin , Chang Xing , Di Jingjing , Xu Long , Cai Bin , Huang Maocai 
Published: February 2025

AbstractTo maximize the utilization of waste laser printed paper fiber (WLPF), WLPF was used as the organic reinforcing phase, high‐density polyethylene (HDPE) was used as the matrix, vinyltrimethoxysilane (A171) and γ‐methacryloxytrimethoxysilane (KH570) were used as coupling agents to modify and prepare WLPF/HDPE composites via a blending‐injection molding process. The weather resistance properties and mechanisms of the composites were systematically analyzed using scanning electron microscopy, Fourier‐transform infrared spectroscopy (FTIR), mechanical analysis, thermogravimetric analysis, and differential scanning calorimetry. The results showed that the KH570‐modified WLPF/HDPE composites retained their excellent tensile and flexural strength after 2000 h of accelerated ultraviolet (UV) aging, and their tensile strength, flexural strength, and flexural modulus were 26.9, 41.0, and 2744.4 MPa, respectively. The thermal property analysis revealed that the thermal stability of the composites decreased after aging. Additionally, the crystallization enthalpy, melting enthalpy, and crystallinity of the composites increased.Highlights
Waste laser printed paper fiber/high‐density polyethylene (WLPF/HDPE) modified composites were prepared by injection molding process.
Ultraviolet (UV) aging properties of WLPF/HDPE composites were investigated for the first time.
KH570 modified composites retained excellent tensile and flexural strength after UV aging.
The thermal properties of the composites after UV aging were also investigated.
Investigation of the effects of walnut shell wood particles on the mechanical properties of injection molded wood‐ polyethylene‐polycarbonate composites
Authors: Al‐Arkawazi Rasool R. K. , Azdast Taher , Hasanzadeh Rezgar 
Published: February 2025

AbstractIn this study, walnut shell is used as an additive in wood‐plastic composite production to explore their potential in manufacturing processes. Different percentages of Polycarbonate (PC) (0, 7.5, 15 wt %) are incorporated with high‐density polyethylene (HDPE) as the base material in various proportions to evaluate its impact on the final product. The study employs the Taguchi technique of the design of experiment (DOE) in injection molding to analyze the data. Moreover, a method involving multi‐criteria decision‐making (MCDM) is used to select the optimal model through practical experiments. The mechanical properties, including tensile strength, flexural strength, and impact strength, are thoroughly analyzed. The results indicate that composite L1, which contains 0 wt % PC and 20 wt % walnut shell with a particle size of 1.5–1 mm, exhibited an 8% increase in tensile strength but a 34.89% decrease in impact strength. In contrast, composite L6, comprised of 7.5 wt % PC and 40 wt % walnut shell, demonstrated a 30.19% increase in flexural strength. To choose the best conditions using the MCDM method, preference percentages are assigned to each result. Considering the importance of these properties for strength, very close ratios (i.e., 34% for flexural strength, 33% for tensile strength, and 33% for impact strength) are allocated. The findings indicate that 0 wt % PC, 20 wt % walnut shell and the particle size ranging from (1.5 to 1) mm is the most effective compound among all the conditions.Highlights
Walnut shell is used as an additive in wood‐plastic composite.
Mechanical aspects of polycarbonate/polyethylene/wood composites are optimized.
Tensile, flexural, and impact strengths are optimized using Taguchi method.
Multi‐criteria decision‐making analysis is implemented for the best conditions.
Bacillus velezensis RKN1111 enhances resistance against Meloidogyne incognita in Cucumis sativus
Authors: Ma Jianqing , Li Keran , He Li , Wang Ning , Xu Yongpan , Tong Xiaolong , Li Ruiyan , Zhang Aimin , Zhao Gangyong , Cao Dandan 
Published: February 2025

AbstractBACKGROUNDMeloidogyne incognita is a highly damaging pathogenic nematode that causes significant annual economic losses. Therefore, the development of reliable biological control agents against M. incognita is imperative. The Bacillus velezensis RKN1111 strain, isolated from inter‐root soil, demonstrates the ability to directly kill M. incognita. In this study, we investigated the effect of RKN1111 in inducing resistance to M. incognita in Cucumis sativus and examined changes in the content of immune‐responsive substances in the induction‐treated cucumber plants.RESULTThe RKN1111 treatment reduced the number of root galls in infected cucumbers, with a maximum reduction of 78.19%. RKN1111 stably colonized cucumber roots, reaching 3.65 × 106 CFU/g in 3 days. The approach and infestation rates of M. incognita on RKN1111‐induced treated cucumber root tips declined at varying time points. Furthermore, RKN1111 induced significant increases (P < 0.05) in hydrogen peroxide (H2O2) and superoxide anion (O2−) contents, as well as in the callose deposition area in cucumber, by up to 59.84, 83.28, and 61.59%, respectively.CONCLUSIONRKN1111 has been demonstrated to stably colonize cucumber root systems and defend against M. incognita infestation by inducing systemic resistance in the host plant. Additionally, RKN1111 elevated the levels of immune‐responsive substances in cucumber plants. RKN1111 has great potential for application in the integrated pest management of M. incognita. © 2025 Society of Chemical Industry.
Dynamics in Patterns of Internal Migration in Poland Between 2017 and 2023 – What Are the Impacts of COVID‐19?
Authors: Korczyński Karol , Kajdanek Katarzyna 
Published: February 2025

ABSTRACTThe COVID‐19 pandemic had a profound spatial impact on economic, cultural and social life, notably altering mobility, including internal migration. Many studies to date looked into various aspects of internal migration patterns after the pandemic outbreak. However, little research has been focused on the area of Central and Eastern Europe. The aim of the paper is to empirically examine the quantitative perspective of registered inter‐municipal migrations in Poland between 2017 and 2023. Specifically, the study sought to determine how the scale and directions of internal migrations in Poland changed across three distinct periods: (1) pre‐pandemic (2017–2019); (2) during the initial COVID‐19 response (2020); (3) post‐restrictions period (2021–2023). We ask to what extent the dominant internal migration trends (depopulation of rural areas and growth in metropolitan areas fuelled by strong suburbanisation trends) were affected during COVID‐19 compared to preceding years. We examine this through analysis of migration intensity, net‐migration rates and the predominance of urban and rural origins and destinations, using population register data on annual flows between municipalities. We discover that the COVID‐19 pandemic resulted in a decrease of migration intensity in 2020 as well as in the following years compared to 2017–2019, with lower net‐migration rates in suburban areas and greater in non‐metropolitan peripheries.
Toosendanin Induces Cell Cycle Arrest and Apoptosis to Suppress Diffuse Large B‐Cell Lymphoma Growth by Inhibiting PI3Kα/β and PLK1 Signaling
Authors: Hu Qian , Wang Mengyao , Chen Meng , Wang Jinjin , Niu Ting 
Published: February 2025

ABSTRACTDiffuse large B‐cell lymphoma (DLBCL) is an aggressive and heterogeneous subtype of non‐Hodgkin lymphoma, with two‐thirds of patients relapsing or resisting existing therapies, highlighting the urgent need for effective treatments. Toosendanin (TSN), a triterpenoid from Meliae Cortex, exhibits significant anti‐cancer activity by modulating cell survival and proliferation. This study investigates the anti‐lymphoma effects and underlying mechanisms of TSN, proposing it as a potential therapeutic agent to address the challenges of DLBCL. Network pharmacology, molecular docking, and transcriptome sequencing were employed to predict TSN's anti‐DLBCL potential. Findings were validated through in vitro and in vivo experiments, including cell viability assays, flow cytometry, quantitative PCR, Western blotting, reverse experiments with small‐molecule inhibitors or genetic editing, and a cell‐derived xenograft (CDX) model. Bioinformatics analyses revealed TSN's strong binding affinity to PI3Kα/β and Polo‐like kinase 1 (PLK1). Experiments showed that TSN downregulated the PI3K/Akt signaling pathway and reduced PLK1 mRNA and protein levels, inducing apoptosis, cell cycle arrest, and cell death in DLBCL cells. RNA sequencing and metabolic assays indicated TSN upregulated cholesterol biosynthesis in DLBCL cells. Co‐treatment with a statin enhanced TSN's anti‐DLBCL effects while mitigating hepatic and pulmonary toxicity. This study identifies TSN as a dual inhibitor of PI3K and PLK1 with significant therapeutic potential for DLBCL. It also proposes a lipid‐modulating strategy to enhance TSN's cytotoxicity while reducing adverse effects, offering a promising approach to improve DLBCL treatment outcomes.
Covalent Organic Framework Nanofilm‐Assisted Laser Desorption Ionization Mass Spectrometry for the Determination of Benzophenone Derivatives in Personal Care Products
Authors: Yan Ling , Zheng Wenjun , Lin Zian 
Published: February 2025

ABSTRACTRationalBenzophenone derivatives, commonly used as UV filters in personal care products (PCPs), are widely prevalent and raise concerns due to their endocrine‐disrupting effects. Sensitive and efficient analytical methods are in demand for their detection. In this study, we developed a TAPB‐DMTP‐covalent organic framework (COF) nanofilm‐assisted laser desorption ionization mass spectrometry (LDI‐MS) method for the quantitative analysis of 2,4‐dihydroxybenzophenone (BP‐1) in PCPs.MethodsThe TAPB‐DMTP‐COF nanofilm was synthesized on indium tin oxide (ITO) glass and utilized as an LDI‐MS substrate. The performance of TAPB‐DMTP‐COF nanofilm‐assisted LDI‐MS for analyzing small molecules (e.g., benzophenone derivatives, phthalates, amino acids, sugars, and nucleosides) was compared to conventional organic matrices (α‐cyano‐4‐hydroxycinnamic acid [CHCA], 2,5‐dihydroxybenzoic acid [DHB], and sinapinic acid [SA]). The reproducibility, salt resistance, sensitivity, and stability of the method were further evaluated. Finally, the technique was applied to quantify BP‐1 in PCPs.ResultsThe TAPB‐DMTP‐COF nanofilm‐assisted LDI‐MS provided stronger mass spectral signals and cleaner backgrounds for small molecules compared to CHCA, DHB, and SA. The method exhibited high reproducibility (RSD = 6.10%) and stability for up to 30 days. BP‐1 in PCPs was quantified with excellent linearity (1–20 μg/mL, r = 0.9993), a low detection limit (0.3 μg/mL), and recovery rates of 94.2%–104.4%, demonstrating the potential of TAPB‐DMTP‐COF nanofilm for sensitive and reliable small‐molecule analysis.ConclusionTAPB‐DMTP‐COF nanofilm‐assisted LDI‐MS offered the advantages of rapid analysis, clean backgrounds, and reproducibility for detecting small molecules, including benzophenone derivatives. This method successfully quantified BP‐1 in PCPs, highlighting its suitability for analyzing complex samples.
A Case of Concomitant Lung Adenocarcinoma and Pleural Metastasis of Papillary Thyroid Carcinoma With BRAF V600E Mutation
Authors: Atsumi Akinari , Tani Tetsuo , Ishioka Kota , Nishikawa Keisuke , Okamoto Yasuhide , Takahashi Saeko 
Published: February 2025

ABSTRACTA 62‐year‐old woman with a history of papillary thyroid carcinoma presented to our hospital with fever and cough and was diagnosed with stage IV non‐small cell lung carcinoma (NSCLC). One year after chemoimmunotherapy, a re‐biopsy of the left pleural tumour lesion was performed. Histological analysis revealed papillary thyroid carcinoma. Another biopsy was performed on the primary tumour, and the histological analysis of the primary tumour lesion confirmed NSCLC. BRAF V600E mutations were detected in both left pleural metastatic lesions of papillary thyroid carcinoma and the primary tumour of NSCLC. Dabrafenib and trametinib reduced both tumour lesions. Here, we report a rare case of concomitant BRAF V600E‐mutated NSCLC and pleural metastasis from papillary thyroid carcinoma.
Flower‐Like Al2O3/AgBr Nanostructures Prepared from Oil Shale Ash for Improved Catalytic Reduction of 4‐nitrophenol
Authors: Li Guanghuan , Fan Shaodong , Li Mengmeng , Chen Xuchang , Lu Yingjie , Liu Yangwen , Long Tao 
Published: February 2025

Abstract4‐Nitrophenol has significant negative impacts on both aquatic and terrestrial organisms due to its ability to slow down the photosynthesis process and its carcinogenic properties. In this study, oil shale ash residue was utilized as an aluminum source to prepare flower‐like γ‐Al₂O₃/AgBr composite photocatalysts via the hydrothermal synthesis method. The structure and morphology of the materials were characterized using field emission scanning electron microscopy (SEM), Ultraviolet–visible spectroscopy (UV–vis), and X‐ray diffraction (XRD), revealing a well‐structured flower‐like morphology with uniformly dispersed AgBr microspheres within the alumina framework. The catalytic performance for the reduction of 4‐nitrophenol by sodium borohydride was also investigated. Results indicated that the efficient loading of AgBr particles on γ‐Al₂O₃ significantly enhanced the photocatalytic activity, increasing the degradation efficiency from 54.8% for pure AgBr to 93.94% within 4.5 min, with a reaction rate constant of 0.6354 min⁻¹. These findings demonstrate that the composite material's enhanced performance is attributed to the synergistic effects of the heterojunction structure and increased active sites. This research provides a meaningful pathway for the comprehensive utilization of oil shale ash residue and offers a promising approach for the development of efficient photocatalysts for wastewater treatment.
Development of ROS‐Sensitive Sulfasalazine‐Loaded Ferrocene Nanoparticles and Evaluation of Their Antirheumatic Effects in a 3D Synovial Hyperplasia Model
Authors: Kim Dongwoo , Kim Chaehyun , Lee So Eun , Kim Sangwoo , Lee Sang‐Il , Park Min Hee , Kim Mingyo , Sung Daekyung , Lee Kangwon 
Published: February 2025

AbstractRheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by joint inflammation, synovial hyperplasia, and bone and cartilage destruction, which significantly impairs physical function and quality of life. Disease‐modifying antirheumatic drugs, such as sulfasalazine (SSZ), are crucial for altering the course and progression of RA; however, their clinical use is hampered by poor water solubility and lack of specificity for the reactive oxygen species (ROS)‐rich environment typical of RA. To overcome these challenges, ROS‐sensitive SSZ‐loaded ferrocene nanoparticles are developed. The nanoparticles facilitate enhanced solubility and stability of SSZ and particularly enable precision targeting through the distinctive redox properties of ferrocene. Using a 3D synovial hyperplasia model with fibroblast‐like synoviocytes derive from RA patients and validate at both the protein and gene levels, these nanoparticles significantly reduce lactate dehydrogenase, ROS, and inflammatory cytokine levels. Further validation using a collagen‐induced arthritis model demonstrates therapeutic efficacy and cytokine modulation in vivo. These findings highlight the potential of ferrocene nanoparticles as a novel and effective therapeutic strategy for RA, offering improved drug delivery and reduced systemic toxicity.
Borders and Confinement in Seafarers’ Realities
Authors: Borovnik Maria 
Published: February 2025

Abstract
Seafarers may come across as highly mobile beings, shifters and movers of global trade, criss-crossing the oceans and living cosmopolitan lives across many borders. And yet, their actual everyday lives are riddled with (im)mobilities and enclosures. This chapter is framed within mobility justice in exploring seafarers’ contrasting realities of mobilities and confinement, freedom and unfreedom, structure and agency, which are determined by the demands of globalisation that assumes uninterrupted trade flows, fluid contract arrangements and speed. The narrative of this scenario normalises 24/7 activities, quick-fix ‘borderless’ mobilities and individual agency that is subdued by the demands of trade and the confinement of the ship space. While these scenarios are quite problematic under usual conditions, the COVID-19 pandemic had exacerbated these situations. This chapter will highlight a number of injustices involved in seafarers’ mobilities to show the difficult and confined scenarios they have to endure.