bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterns and risk factors associated with aromatase inhibitor‐related arthralgia among breast cancer survivors
Authors: Mao Jun J. , Stricker Carrie , Bruner Deborah , Xie Sharon , Bowman Marjorie A. , Farrar John T. , Greene Brandon T. , DeMichele Angela 
Published: June 2009

AbstractBACKGROUND:Arthralgia is common in postmenopausal breast cancer survivors (BCS) who are receiving aromatase inhibitors (AIs). The objective of this study was to evaluate the perceived onset, characteristics, and risk factors for AI‐related arthralgia (AIA).METHODS:In a cross‐sectional survey of postmenopausal BCS who were receiving adjuvant AI therapy at a university‐based oncology clinic, patient‐reported attribution of AIs as a cause of joint pain was used as the primary outcome. Multivariate logistic regression analyses were performed to evaluate risk factors.RESULTS:Among 300 survey respondents, 139 (47%) attributed AI as a cause of their current arthralgia. Of those patients, 74% recognized the onset of AIA within 3 months of starting medication, and 67% rated joint pain as moderate or severe in the previous 7 days. In multivariate logistic regression analyses, the time since last menstrual period (LMP) was the only significant predictor of AIA. Controlling for covariates, the women who had their LMP within 5 years had the highest probability of reporting AIA (73%), whereas those who had their LMP ≥10 years previously had the lowest probability of reporting AIA (35%; adjusted odds radio, 3.39; 95% confidence interval, 1.21‐9.44; P = .02). Wrists/hands, ankles/feet, elbows, and knees appeared to be associated more strongly with AI‐related symptoms than non‐AI–related joint symptoms (all P < .01).CONCLUSIONS:AIA was common, began within the first 3 months of therapy in most patients, and appeared to be related inversely to the length of time since cessation of menstrual function. These findings suggest that estrogen withdrawal may play a role in the mechanism of this disorder. Cancer 2009. © 2009 American Cancer Society.
[F‐18]‐fluorodeoxy‐D‐glucose–positron emission tomography response is associated with outcome for extremity osteosarcoma in children and young adults
Authors: Hawkins Douglas S. , Conrad Ernest U. , Butrynski James E. , Schuetze Scott M. , Eary Janet F. 
Published: June 2009

AbstractBACKGROUND:Response to neoadjuvant chemotherapy is 1 of the most powerful prognostic factors for extremity osteosarcoma. [F‐18]‐fluorodeoxy‐D‐glucose–positron emission tomography (FDG‐PET) is a noninvasive imaging modality that is used to predict histopathologic response. To determine the prognostic value of FDG‐PET response for progression‐free survival (PFS) in osteosarcoma, the authors of this report reviewed the University of Washington Medical Center experience.METHODS:Forty patients with extremity osteosarcoma were evaluated by FDG‐PET. All patients received neoadjuvant and adjuvant chemotherapy. FDG‐PET standard uptake values (SUVs) before neoadjuvant chemotherapy (SUV1) and after neoadjuvant chemotherapy (SUV2) were analyzed and correlated with histopathologic response.RESULTS:The median SUV1 was 6.8 (range, 3.0‐24.1), the median SUV2 was 2.3 (range, 1.2‐12.8), and the median SUV2 to SUV1 ratio (SUV2:1), was 0.36 (range, 0.12‐1.10). A good FDG‐PET response was defined as anSUV2 <2.5 or an SUV2:1 ≤0.5. FDG‐PET responses according to SUV2 and SUV2:1 were concordant with histologic response in 58% and 68% of patients, respectively. SUV2 was associated with outcome (4‐year PFS, 73% for SUV2 <2.5 vs 39% for SUV2 ≥2.5; P = .021). Both the initial disease stage and the histologic response were associated with outcome.CONCLUSIONS:FDG‐PET imaging of extremity osteosarcoma was correlated only partially with a histologic response to neoadjuvant chemotherapy. An SUV2 <2.5 was associated with improved PFS. Future prospective studies are warranted to determine whether FDG‐PET imaging may be used as a predictor of outcome independent of initial disease stage. Cancer 2009. © 2009 American Cancer Society.
Prevalence and predictors of emotional and behavioural functioning of children where a parent has cancer
Authors: Thastum Mikael , Watson Maggie , Kienbacher Christian , Piha Jorma , Steck Barbara , Zachariae Robert , Baldus Christiane , Romer Georg 
Published: June 2009

AbstractBACKGROUND:This study aimed to evaluate prevalence and risk factors for emotional and behavioral problems in dependent children of cancer patients using a multinational research design.METHODS:The sample comprised 350 ill parents, 250 healthy partners, and 352 children. Parents assessed the child's psychological functioning using the Child Behavior Checklist, parental depression using the Beck Depression Inventory, family functioning using the General Functioning subscale of the Family Assessment Device, quality of life using short‐form questionnaire, and adolescents (N = 168) self‐reported psychological functioning using the Youth Self Report.RESULTS:Children and adolescents, in particular latency‐aged boys and adolescent girls, were of higher risk of psychosocial problems than norms. There was a higher risk of problems when the father was ill than when the mother was ill, but it remains unclear whether this difference was due to the different diagnoses of fathers and mothers, gender or other factors. The best predictor of internalizing problems in children and adolescents was parental depression, and the best predictor of externalizing problems in children and adolescents was family dysfunction.CONCLUSIONS:The results indicate the need for a family‐oriented approach to psychological support of cancer patients. Cancer 2009. © 2009 American Cancer Society.
Tumor border configuration added to TNM staging better stratifies stage II colorectal cancer patients into prognostic subgroups
Authors: Zlobec Inti , Baker Kristi , Minoo Parham , Hayashi Shinichi , Terracciano Luigi , Lugli Alessandro 
Published: June 2009

AbstractBACKGROUND:Reproducible and well characterized prognostic histomorphologic criteria added to current pathological staging could have an immediate effect on refining prognosis in colorectal cancer. The aim of this study was to determine the additive effect of tumor border configuration and peritumoral lymphocytic infiltration on the selection of patients for adjuvant therapy classified by TNM.METHODS:A total of 1420 primary colorectal cancers with complete clinicopathological data from multiple treatment centers were analyzed. The prognostic effect of tumor border configuration (pushing or infiltrating) and peritumoral lymphocytic infiltration was assessed, validated by resampling of the data, and compared with TNM staging. All P values were 2‐sided.RESULTS:Multivariate analysis confirmed the adverse prognostic value of the tumor border configuration (P < .001), but not of peritumoral lymphocytic infiltration. The addition of tumor border configuration to T and N category identified 2 major prognostic subgroups (relative risk of death, 4.75; 95% confidence interval [CI], 2.53‐8.94). Moreover, stage II patients with a pushing border had a 5‐year survival rate of 82.1% (95% CI, 71.8%‐90.3%), whereas an infiltrating border resulted in a significantly more adverse outcome (5‐year survival rate, 62.7%; 95% CI, 48.0‐76.2%), closely resembling that of stage III patients. Similar results were obtained after adjusting for adjuvant therapy (P < .001).CONCLUSIONS:The classification of patients into prognostic subgroups is improved with the addition of tumor border configuration to TNM stage. In particular, patients with stage II disease characterized by an infiltrating tumor border have poor clinical outcome and represent a subset of lymph node‐negative patients who could be considered for adjuvant therapy. Cancer 2009. © 2009 American Cancer Society.
Quality of pathologic response and surgery correlate with survival for patients with completely resected bladder cancer after neoadjuvant chemotherapy
Authors: Sonpavde Guru , Goldman Bryan H. , Speights V. O. , Lerner Seth P. , Wood David P. , Vogelzang Nicholas J. , Trump Donald L. , Natale Ronald B. , Grossman H. Barton , Crawford E. David 
Published: June 2009

AbstractBACKGROUND:In a retrospective study of Southwestern Oncology Group (SWOG)‐S8710/INT‐0080 (radical cystectomy [RC] alone vs 3 cycles of neoadjuvant chemotherapy [NC] with methotrexate, vinblastine, doxorubicin, and cisplatin before RC for bladder cancer), factors found to be associated with improved overall survival (OS) included pathologic complete response, defined as P0; treatment with NC; completion of RC with negative surgical margins; and ≥10 pelvic lymph nodes (LNs) removed.METHODS:The authors used stratified Cox regression to retrospectively study the association of quality of pathologic response after RC with OS in the subset of S8710 patients who received NC and RC with negative surgical margins.RESULTS:Of 154 patients who received NC, 68 (44.2%) were <P2 (P0, Pa, P1, or carcinoma in situ [CIS]) at RC, 46 (29.9%) were P0, and the remainder had P2+ disease or did not undergo RC. In 115 patients who had RC with negative surgical margins, compared with P0 patients, those with residual Pa, P1, or CIS appeared to have worse OS (P = .054); OS was significantly worse for patients with residual P2+ disease (P = .0006). LN–positive (LN+) disease was found to be associated with worse OS than LN–negative (LN−) disease (P = .0005). Patients with LN− disease (ie, those with <10 LNs removed) appeared to have inferior OS compared with those with 10+ LNs removed (P = .079). The combination of pre‐NC clinical stage and post‐RC pathologic stage was found to be predictive of OS (P < .0001).CONCLUSIONS:NC and RC with negative surgical margins for bladder cancer followed by pathologic P0 and LN− disease were found to correlate with improved OS. A combination of baseline clinical stage and post‐RC pathologic stage may better predict OS. Cancer 2009. © 2009 American Cancer Society.
A meta‐predictor framework for prefetching in object‐based DSMs
Authors: Beyler Jean Christophe , Klemm Michael , Clauss Philippe , Philippsen Michael 
Published: June 2009

AbstractDynamic optimizers modify the binary code of programs at runtime by profiling and optimizing certain aspects of the execution. We present a completely software‐based framework that dynamically optimizes programs for object‐based distributed shared memory (DSM) systems on clusters. In DSM systems, reducing the number of messages between cluster nodes is crucial. Prefetching transfers data in advance from the storage node to the local node so that communication is minimized. Our framework uses a profiler and a dynamic binary rewriter that monitor the access behavior of the application and place prefetches where they are beneficial to speed up the application. In addition, we use two distinct predictors to handle different types of access patterns. A meta‐predictor analyzes the memory access behavior and dynamically enables one of the predictors. Our system also adapts the number of prefetches per request to best fit the application's behavior. The evaluation shows that the performance of our system is better than the manual prefetching. The number of messages sent decreases by up to 90%. Performance gains of up to 80% can be observed on benchmarks. Copyright © 2009 John Wiley & Sons, Ltd.
Synthesis, Characterization and Reactivity of Dinuclear and Trinuclear Aluminum‐Bridged Ferrocenophanes
Authors: Wrackmeyer Bernd , Klimkina Elena V. , Milius Wolfgang 
Published: June 2009

AbstractFerrocene derivatives bearing substituents with aluminum in the 1,1′‐positions, in the absence of donor ligands, possess rather unusual structural features. Starting from various dipyridine adducts of such 1,1′‐disubstituted ferrocene derivatives, it proved possible to trap the pyridine as the adducts R3Al(py) and monitor the formation of dinuclear and trinuclear aluminum‐bridged ferrocenophanes in solution by NMR spectroscopy. For the first time, the dynamic behaviour of such complexes was studied and a complete set of NMR spectroscopic data has been reported. The dinuclear complex [Fe(η5‐C5H4)2]2Al3Et5 was characterized by X‐ray structural analysis. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Light‐emitting‐diode‐induced chemiluminescence detection for capillary electrophoresis
Authors: Zhang Xinfeng , Zhang Jiyou , Wu Xi , Lv Yi , Hou Xiandeng 
Published: June 2009

AbstractIn this work, an LED‐induced‐chemiluminescence (LED‐CL) system was developed to extend the application of CL detection in CE. In the LED‐CL, the analyte photooxidizes luminol under the irradiation of LEDs and generates CL. Taking the advantage of the small size nature of LEDs, the constructed photoreactor is greatly miniaturized, and especially suitable as a CE detector. The feasibility of the proposed detector was evaluated by detection of riboflavin (RF), flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) after CE separation. Under the optimized conditions, the LODs for RF, FMN and FAD were 0.007, 0.02 and 0.1 μg/mL, respectively, better than those by UV detection. The RSDs were 3.4, 3.6 and 4.1% for 0.5 μg/mL RF, 2 μg/mL FMN and 5 μg/mL FAD, respectively. The LED‐CL detector features low cost, miniaturization, fast response, high sensitivity and good reproducibility.
Functional and structural changes in the memory network associated with left temporal lobe epilepsy
Authors: Voets Natalie L. , Adcock Jane E. , Stacey Richard , Hart Yvonne , Carpenter Katherine , Matthews Paul M. , Beckmann Christian F. 
Published: June 2009

AbstractUnderstanding functional plasticity in memory networks associated with temporal lobe epilepsy (TLE) is central to predicting memory decline following surgery. However, the extent of functional reorganization within memory networks remains unclear. In this preliminary study, we used novel analysis methods assessing network‐level changes across the brain during memory task performance in patients with TLE to test the hypothesis that hippocampal functions may not readily shift between hemispheres, but instead may show altered intra‐hemispheric organization with unilateral damage. In addition, we wished to relate functional differences to structural changes along specific fibre pathways associated with memory function. Nine pre‐operative patients with intractable left TLE and 10 healthy controls underwent functional MRI during complex scene encoding. Diffusion tensor imaging was additionally performed in the same patients. In our study, we found no evidence of inter‐hemispheric shifts in memory‐related activity in TLE using standard general linear model analysis. However, tensor independent component analysis revealed significant reductions in functional connectivity between bilateral MTL, occipital and left orbitofrontal regions among others in left TLE. This altered orbitofrontal activity was directly related to measures of fornix tract coherence in patients (P < 0.05). Our results suggest that specific fibre pathways, potentially affected by MTL neurodegeneration, may play a central role in functional plasticity in TLE and highlight the importance of network‐based analysis approaches. Relative to standard model‐based methods, novel objective functional connectivity analyses may offer improved sensitivity to subtle changes in the distribution of memory functions relevant for surgical planning in TLE. Hum Brain Mapp, 2009. © 2009 Wiley‐Liss, Inc.
Hydrological impacts of climate change predicted for an inland lake catchment in Ontario by using monthly water balance analyses
Authors: Yao Huaxia , Scott Lem , Guay Christiane , Dillon Peter 
Published: June 2009

AbstractPotential hydrological impacts of climate change on long‐term water balances were analysed for Harp Lake and its catchment. Harp Lake is located in the boreal ecozone of Ontario, Canada. Two climate change scenarios were used. One was based on extrapolation of long‐term trends of monthly temperature and precipitation from a 129‐year data record, and another was based on a Canadian general circulation model (GCM) predictions. A monthly water balance model was calibrated using 26 years of hydrological and meteorological data, and the model was used to calculate hydrological impact under two climate change scenarios.The first scenario with a warmer and wetter climate predicted a smaller magnitude of change than the second scenario. The first scenario showed an increase in evaporation each month, an increase in catchment runoff in summer, fall and winter, but a decrease in spring, resulting in a slight increase in lake level. Annual runoff and lake level would increase because the precipitation change overrides evaporation change. The second scenario with a warmer, drier climate predicted a greater change, and indicated that evaporation would increase each month, runoff would increase in many months, but would decrease in spring, causing the lake level to decrease slightly. Annual runoff and lake level would decrease because evaporation change overrides precipitation change. In both scenarios, the water balance changes in winter and spring are pronounced. Copyright © 2009 John Wiley & Sons, Ltd.
Gigantism of the Australian Diprotodon Owen 1838 (Marsupialia, Diprotodontoidea) through the Pleistocene
Authors: Price Gilbert J. , Piper Katarzyna J. 
Published: June 2009

AbstractDiprotodon Owen, 1838 was one of the first fossil mammals described from Australia and has the distinction of being the largest ever marsupial. However, until recently its taxonomy was unclear and knowledge of its continental distribution, palaeoecology and evolution was poorly known. This paper describes cranial elements from an unusually small‐bodied Diprotodon from the Early Pleistocene Nelson Bay Formation, Portland, Australia. It is intermediate in size between the smaller‐bodied Pliocene ancestor, Euryzygoma dunense de Vis 1895 and the larger‐bodied Late Pleistocene D. optatum Owen, 1838. However, it is morphologically inseparable from Late Pleistocene Diprotodon and is here referred to as D. ?optatum. A temporal morphocline most parsimoniously explains the medium body size of the Nelson Bay taxon; thus we provide the first evidence of a transitional form within Diprotodon. The cause(s) of gigantism of the E. dunense–D. ?optatum–D. optatum lineage through the late Cainozoic is unclear but most likely involved the physiological response to changes in the physical and/or biotic environment. Although the size changes within the lineage may have been initially advantageous, they were most likely disadvantageous when the optimum body size was obtained. Our results suggest that Diprotodon was at its largest ever body size during the Late Pleistocene – the time period that coincided with its extinction. Copyright © 2009 John Wiley & Sons, Ltd.
Thermosensitive and Dissolution Properties in Nanocomposite Polymer Hydrogels
Authors: Wu Chia‐Jung , Schmidt Gudrun 
Published: June 2009

AbstractWe investigate the phase transition behavior and dissolution resistant properties of thermo‐sensitive nanocomposite hydrogels made from PEO‐PPO‐PEO triblock copolymer (Pluronic F127) and Laponite silicate nanoparticles. The rapid dissolution properties of F127 copolymer hydrogels usually limit their use as sustained release drug carriers. We overcome this limitation by synergistic combination of nanoparticle gelation characteristics with polymer thermo‐sensitivity. We present a proof of concept that the temperature‐dependent phase transitions can be shifted as a function of hydrogel composition and that the dissolution of the polymer hydrogels as well as the release of a model drug, albumin, can be significantly slowed down by addition of nanoparticles. The dissolution resistant properties generated will prove useful in the future formulation, processing and application of our polymer hydrogels for sustained release drug delivery carriers.magnified image
Identification of process parameters affecting distortion of disks for gear manufacture Part I: casting, forming and machining
Authors: Clausen B. , Frerichs F. , Kohlhoff T. , Lübben Th. , Prinz C. , Rentsch R. , Sölter J. , Surm H. , Stöbener D. , Klein D. 
Published: June 2009

AbstractTowards determining the influence parameters on the distortion of gear wheels made from the steel grade 20MnCr5 (SAE 5120), in this work the analysis of the distortion of disks is presented. The parameter identification was performed by means of the design of experiments (DoE). According to a comprehensive approach to distortion engineering, the entire manufacturing chain was considered from casting to the final heat treatment. Due to the complexity of this manufacturing chain the investigation was divided into two parts, the processes before the final heat treatment and the final heat treatment process itself. Here, in part I, the results of the investigation of the processes before the final heat treatment are discussed while in part II the results of the final heat treatment are presented. Releasing the accumulated distortion potential of the influence parameters of the processes from casting to cutting by a standard case hardening led to characteristic size changes of the disks. For the shape changes the cutting strategy showed a high influence on the change of dishing. Assuming that the cutting strategy can continuously be varied there should be a strategy for which no change of the dishing occurs, which would provide the means for compensation of distortion.
Clinical phenotype and neuroimaging findings in a French family with hereditary ferritinopathy (FTL498‐499InsTC)
Authors: Ory‐Magne Fabienne , Brefel‐Courbon Christine , Payoux Pierre , Debruxelles Sabrina , Sibon Igor , Goizet Cyril , Labauge Pierre , Menegon Patrice , Uro‐Coste Emmanuelle , Ghetti Bernardino , Delisle Marie Bernadetle , Vidal Ruben , Rascol Olivier 
Published: June 2009

AbstractTo describe a family with a hereditary ferritinopathy (HF) due to a mutation in the ferritin light chain gene (FTL498‐499InsTC mutation). Case reports of the clinical features, MRI, 18FDG PET, and pathological findings observed in this family with two patients described in more details. Postural tremor (phenotype‐1) or cerebellar signs (phenotype‐2) were the first neurological symptoms detected. Parkinsonian, cerebellar and pyramidal syndromes, abnormal involuntary movements, dementia were observed in both phenotypes at more advanced stages. Beside characteristics T2* hypointense signals suggestive of iron accumulation in the striatum, mesencephalon, and cerebellum, we detected more diffuse changes including cerebellar, cortical and subcortical atrophy, cortical iron deposition, and severe leukoencephalopathy. 18FDG PET showed frontal and cerebellum hypometabolism with more severe frontal defect in patients with cognitive decline. Pathological examination showed ferritin and iron deposition in the liver, kidney, muscle, skin, and in the central nervous system. Members of this family affected by HF due to the FTL498‐499InsTC mutation have a specific clinical presentation with initial postural tremor or cerebellar ataxia, followed by pyramidal and extrapyramidal motor syndromes and late severe subcortical dementia. © 2009 Movement Disorder Society