bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distortion product otoacoustic emissions following stapedectomy versus stapedotomy
Authors: Migirov L , Wolf M 
Published: October 2009

AbstractObjectives:To evaluate distortion product otoacoustic emissions following stapes surgery in patients with otosclerosis, and to compare in this respect two surgical techniques used in our department.Method:This retrospective study included 17 stapedectomy and 23 stapedotomy patients aged 16–68 years who had been followed up for at least 12 months. Distortion product otoacoustic emission results at 2, 3, 4 and 5 kHz (i.e. =f2, with 2f1 − f2 = 0.6f2) were obtained pre-operatively and four weeks post-operatively. The control group included 13 volunteers aged 18–50 years with normal hearing and normal otoscopic findings.Results:Distortion product otoacoustic emissions were detected pre-operatively in 34.8 per cent of stapedotomy patients and 29.4 per cent of stapedectomy patients, and post-operatively in 91.3 per cent of stapedotomy patients and 88.2 per cent of stapedectomy patients. The differences between the stapedotomy and stapedectomy groups were statistically insignificant for each tested frequency, both pre- and post-operatively. The patients' post-operative distortion product otoacoustic emission amplitudes were less than those of normal hearing individuals, even in patients with complete air–bone gap closure and a significant improvement in hearing.Conclusion:Distortion product otoacoustic emissions were detected in most of our patients following successful stapes surgery, and appeared to be unaffected by the surgical technique or prosthesis used.
Sphenoid sinus mucocele: 10 cases and literature review
Authors: Soon S R , Lim C M , Singh H , Sethi D S 
Published: October 2009

AbstractIntroduction:Sphenoid sinus mucoceles represent only 1–2 per cent of all paranasal sinus mucoceles. Patients may present with a myriad of symptoms. Pre-operative investigations include nasoendoscopy, computed tomography and/or magnetic resonance imaging. Treatment is by endoscopic sinus surgery.Methodology:A retrospective review of the archives of the Singapore General Hospital otolaryngology department (1999–2006) identified 10 cases of sphenoid sinus mucocele. Patient demographics, presenting symptoms, investigations and treatment were evaluated.Results:The 10 patients identified (three women and seven men) had a mean age of 54.5 years (range 24–70 years). Thirty per cent of patients had a history of nasopharyngeal carcinoma treated with radiotherapy. Presenting symptoms, in order of decreasing frequency, were: ocular symptoms (50 per cent), headaches (30 per cent), nasal discharge (30 per cent) and facial pain (10 per cent). All patients underwent pre-operative computed tomography or magnetic resonance imaging. Twenty per cent of patients had evidence of intracranial involvement on imaging. All patients underwent uncomplicated transnasal sphenoidotomy and drainage of the mucocele. There was no clinical or radiological evidence of recurrence at a mean follow up of 29 months (range 4–90 months).Conclusion:Sphenoid sinus mucocele is a rare condition. In this study, radiation to the head and neck appeared to be a predisposing factor, and eye symptoms were the commonest presentation. Endoscopic sinus surgery is a safe and effective treatment modality.
On the systematic social role of expressed emotions: An embodied perspective
Authors: Vermeulen Nicolas 
Published: October 2009

AbstractVigil suggests that expressed emotions are inherently learned and triggered in social contexts. A strict reading of this account is not consistent with the findings that individuals, even those who are congenitally blind, do express emotions in the absence of an audience. Rather, grounded cognition suggests that facial expressions might also be an embodied support used to represent emotional information.
Organizing for Cancer Control: The Diffusion of a Dynamic Innovation in a Community Cancer Network
Authors: McKinney Martha M. , Barnsley Janet M. , Kaluzny Arnold D. 
Published: October 2009

AbstractThis paper examines the diffusion of a “dynamic” innovation—research on the prevention and control of cancer—in a community cancer network. By analyzing the social structures and communication strategies of network members, as well as the attributes of the innovation, the authors explain why this innovation is diffusing more slowly than its “formed” counterpart—research on the treatment of cancer.
Magnetic Resonance Imaging: Diffusion of Technology in an Ambulatory Setting
Authors: Bautz James B. , Schectman Joel M. , Elinsky Elaine G. , Pawlson L. Gregory 
Published: October 2009

AbstractTo better understand technology diffusion in an ambulatory care setting, we analyzed adult outpatients’ use of magnetic resonance (MR) and computed tomography (CT) imaging in a group-model HMO between 1986 and 1989. The use of MR, but not CT, Increased at a rapid pace with only a small proportion of the scans being accounted for by primary care physicians.
Problems in Assessing the Technology of Critical Care Medicine
Authors: Sibbald William J. , Inman Kevin J. 
Published: October 2009

AbstractTechnology assessment is becoming increasingly important in the area of critical care due both to the explosion of technology associated with this discipline and to the realization that future demand for these health care resources will undoubtedly exceed the ability to pay. Technology assessment remains both confusing and controversial to many physicians. This review tries to address some of the confusion by reviewing the basic strategies involved in this process. From there, problems and prospects for the evaluation of critical care as a program are presented, followed by the assessment of components within the area of critical care. Finally, recommendations are made on how technology assessment could proceed in the future to best achieve the efficient provision of this service.
Critically Examining Intensive Care
Authors: Miranda Dinis Reis 
Published: October 2009

AbstractThe economic recession of the last decade brought intensive care systems under the light of cost-effectiveness analysis, making use of several instruments available in medical practice, and others adapted from for-profit enterprises. The present concept of intensive care, particularly its functional and organizational interactions with traditional specialties, is at the brink of an important revaluation. Studies of the cost-effectiveness of therapeutic actions may be grossly biased if they do not consider the complete process of care (before, during, and after treatment), analyzing even its smallest elements.
Introduction: Vaccine Technologies and Public Health: Why a Critical Review Now?
Authors: Freeman Phyllis , Robbins Anthony 
Published: October 2009

AbstractSince Jenner's time, there have always been enthusiasts and skeptics about the role of vaccines in the prevention of disease. This introduction explains why, at this time, it is crucial to assess the historical role vaccines have played in limiting damage caused by infectious diseases, the role they can play in the future, and the technologies that are best suited to achieving optimal gains for public health and development worldwide.
The Promise of New Technologies
Authors: La Montagne John R. , Rabinovich N. Regina 
Published: October 2009

AbstractEfforts to provide the benefits of immunization to the world's children have reached an important crossroad. While remarkable progress has been achieved in successfully administering six important childhood vaccines (diphtheria, tetanus, polio, pertussis, measles, and tuberculosis), the benefits of new vaccines, such as hepatitis B and Haemophilus influenzae type B glycoconjugate vaccines, have not been realized except in the most developed countries. The three reasons often cited to explain this problem include poor access to immunization services, the evolution of complex primary immunization schedules, and the additional expense associated with new vaccines, potentially depleting scarce resources. The establishment of the Children's Vaccine Initiative is an organized effort to improve immunization by both technological and organizational innovation. Simplification of the vaccination process can be achieved by developing new combination vaccines or reducing the number of immunizations with vaccines that stimulate protective immune responses. Improvements in the organization of efforts to immunize children will also enhance the prospects of protecting the world's children from infectious diseases. To achieve the goals articulated in the Declaration of New York, the issues of transition from the old to the new vaccines must be addressed. Research on vaccines and technological innovation at all levels will be required to achieve these goals.
The Contribution of Immunization to Economic Development
Authors: Parker David , Hill Terrel 
Published: October 2009

AbstractImmunization received intensive support during the 1980s in light of its demonstrable value, relatively low cost, and established infrastructure. The goal of universal childhood immunization was achieved in 1990 on the basis of a strategy of expanding coverage, technological improvements, and social mobilization. Although its impact is difficult to quantify precisely, the Expanded Programme on Immunization (EPI) has had significant positive effects on national and household economies as a result of the reduction of morbidity and mortality. It also has contributed to the development of the managerial and operational capacity of health systems and to the generation of widespread social and political support for health actions through a variety of different mechanisms. Priorities for the next decade include attention to policies to ensure the maintenance of high levels of coverage, continued technical development, and further strengthening of EPI planning and management.
The Role of Vaccine Research and Development in the Scientific Development of Middle-Income Countries
Authors: Martínez-Palomo Adolfo , López-Cervantes Malaquías , Freeman Phyllis 
Published: October 2009

AbstractAs a new global strategy for improving public health, the Children's Vaccine Initiative implicitly raises, once again, the question of the role of science in developing countries. If there are to be new and improved vaccines, better delivery systems, and simplified immunization schedules, there must be substantial analysis, laboratory activity, and fieldwork to ensure that the new products are ready for effective use. In the context of these requirements, this paper reviews the possibilities for vaccine research and development in middle-income countries and the benefits in terms of fostering socioeconomic development through integrated scientific health research.
Desirable Immunologic Characteristics for the Development of an Ideal Vaccine
Authors: Ada Gordon 
Published: October 2009

AbstractThe efficacy of vaccines for prophylactic use is a function of the immune response elicited by activated lymphocytes. Based on the current understanding of these responses, their induction, and the most effective ways to obtain long-lived immunity, a novel protocol for the vaccination of children against seven childhood diseases, involving only two visits for vaccine administration, is proposed.
Modern Concepts in Immune Recognition and Lymphocyte Activation: Relevance for the Development of Useful Vaccines
Authors: Germain Ronald N. 
Published: October 2009

AbstractAdaptive immunity requires both specific recognition of an antigen and its translation into appropriate lymphocyte responses. This paper reviews the striking differences in B- and T-lymphocyte antigen recognition, details the pathways for conversion of protein antigens into peptide–major histocompatibility complex molecule ligands for T-cell receptors, and summarizes the roles of costimulatory signals in lymphocyte activation. This information is used to suggest new approaches for the rational design of vaccines.
Effective Mucosal Immunity: Current Concepts for Vaccine Delivery and Immune Response Analysis
Authors: McGhee Jerry R. , Kiyono Hiroshi 
Published: October 2009

AbstractIt is now established that the mucosal immune system is a separate entity and is regulated in a different fashion than that in peripheral lymphoid tissues (the systemic immune system). In this brief review, five selected areas within the field of mucosal immunity are discussed in the context of the goals for vaccines for the Children's Vaccine Initiative.
Glycoconjugate Vaccines: What Next?
Authors: Stein Kathryn E. 
Published: October 2009

AbstractThe principle that infants can be protected from invasive diseases caused by encapsulated organisms has been proved with the introduction ofHaemophilus influenzaetype b conjugate vaccines. The use of glycoconjugates to implement some of the goals of the Children's Vaccine Initiative requires a clear delineation of the chemical and immunological specifications for optimal vaccines.
The Thermostability of Vaccines: Technologies for Improving the Thermostability of the Oral Poliovirus Vaccine
Authors: Lemon Stanley M. , Milstien Julie B. 
Published: October 2009

AbstractTechnologies that promise to enhance the stability of vaccines are likely to be determined by the product-specific physical structure and biological functions of the specific vaccine immunogens. Research may define the extent to which the stability of oral poliovirus vaccine may be improved by the addition of certain antiviral components that bind to the poliovirus capsid or by the application of novel drying technologies.
Software-engineering challenges of building and deploying reusable problem solvers
Authors: O'Connor Martin J. , Nyulas Csongor , Tu Samson , Buckeridge David L. , Okhmatovskaia Anna , Musen Mark A. 
Published: October 2009

AbstractProblem solving methods (PSMs) are software components that represent and encode reusable algorithms. They can be combined with representations of domain knowledge to produce intelligent application systems. A goal of research on PSMs is to provide principled methods and tools for composing and reusing algorithms in knowledge-based systems. The ultimate objective is to produce libraries of methods that can be easily adapted for use in these systems. Despite the intuitive appeal of PSMs as conceptual building blocks, in practice, these goals are largely unmet. There are no widely available tools for building applications using PSMs and no public libraries of PSMs available for reuse. This paper analyzes some of the reasons for the lack of widespread adoptions of PSM techniques and illustrate our analysis by describing our experiences developing a complex, high-throughput software system based on PSM principles. We conclude that many fundamental principles in PSM research are useful for building knowledge-based systems. In particular, the task–method decomposition process, which provides a means for structuring knowledge-based tasks, is a powerful abstraction for building systems of analytic methods. However, despite the power of PSMs in the conceptual modeling of knowledge-based systems, software engineering challenges have been seriously underestimated. The complexity of integrating control knowledge modeled by developers using PSMs with the domain knowledge that they model using ontologies creates a barrier to widespread use of PSM-based systems. Nevertheless, the surge of recent interest in ontologies has led to the production of comprehensive domain ontologies and of robust ontology-authoring tools. These developments present new opportunities to leverage the PSM approach.
Workflow agents versus expert systems: Problem solving methods in work systems design
Authors: Clancey William J. , Sierhuis Maarten , Seah Chin 
Published: October 2009

AbstractDuring the 1980s, a community of artificial intelligence researchers became interested in formalizing problem solving methods (PSMs) as part of an effort called “second-generation expert systems.” We provide an example of how we are applying second-generation expert systems concepts in an agent-based system for space flight operations, the orbital communications adapter mirroring system (OCAMS), which was developed in the Brahms multiagent framework. Brahms modeling language provides an ontology for simulating work practices, including groups, agents, activities, communications, movements, and geographic areas.Activitiesare a behavioral unit of analysis to be contrasted withtasks, a functional unit of analysis. Problem solving occurs in the context of activities in the service of tasks; appropriate PSMs depend on the context: which people/roles are participating, what tools are available, how the results will be evaluated, and so forth. A work practice simulation facilitates designing workflow tools that appropriately interact with the physical and organizational context in which work occurs. OCAMS was developed using a simulation-to-implementation methodology, in which a prototype workflow tool was embedded in a Brahms simulation of how people would use the tool. The reusable components in a workflow system like OCAMS include entire “problem solvers” (e.g., a planning subsystem), interoperability frameworks, and agents that inspect and change the world. Thus, a tool kit for building workflow tools requires more than a library of PSMs, which play a relatively small role in the overall multiagent, systems-integration architecture. Our research concern has shifted to situations that may arise that are outside the OCAMS' capability. In practical decision making, people must reflect on the validity of their models. As programs becoming actors in the workplace, we need to develop systems that help people to understand the limitations of the models that drive the automated operations, which means in part detecting when the formalizations in the system are inadequate.
Problem solving methods in a global networked age
Authors: Domingue John , Fensel Dieter 
Published: October 2009

AbstractWe believe that the future for problem solving method (PSM) derived work is very promising. In short, PSMs provide a solid foundation for creating a semantic layer supporting planetary-scale networks. Moreover, within a world-scale network where billions services are used and created by billions of parties inad hocdynamic fashion we believe that PSM-based mechanisms provide the only viable approach to dealing the sheer scale systematically. Our current experiments in this area are based upon a generic ontology for describing Web services derived from earlier work on PSMs. We outline how platforms based on our ontology can support large-scale networked interactivity in three main areas. Within a large European project we are able to map business level process descriptions to semantic Web service descriptions, to enable business experts to manage and use enterprise processes running in corporate information technology systems. Although highly successful, Web service-based applications predominately run behind corporate firewalls and are far less pervasive on the general Web. Within a second large European project we are extending our semantic service work using the principles underlying the Web and Web 2.0 to transform the Web from a Web of data to one where services are managed and used at large scale. Significant initiatives are now underway in North America, Asia, and Europe to design a new Internet using a “clean-slate” approach to fulfill the demands created by new modes of use and the additional 3 billion users linked to mobile phones. Our investigations within the European-based Future Internet program indicate that a significant opportunity exists for our PSM-derived work to address the key challenges currently identified: scalability, trust, interoperability, pervasive usability, and mobility. We outline one PSM-derived approach as an exemplar.
A functionalist perspective on social anxiety and avoidant personality disorder
Authors: LaFreniere Peter 
Published: October 2009

AbstractA developmental–evolutionary perspective is used to synthesize basic research from the neurosciences, ethology, genetics, and developmental psychology into a unified framework for understanding the nature and origins of social anxiety and avoidant personality disorder. Evidence is presented that social anxiety disorder (social phobia) and avoidant personality disorder may be alternate conceptualizations of the same disorder because they have virtually the same symptoms and genetic basis, and respond to the same pharmacologic and psychotherapeutic interventions. A functionalist perspective on social anxiety is formulated to (a) explain the origins of normative states of anxiety, (b) outline developmental pathways in the transition from normative anxiety to social anxiety and avoidant personality disorders, and (c) account for the processes leading to gender-differentiated patterns of anxiety-related disorders after puberty.
Developmental origins of early antisocial behavior
Authors: Calkins Susan D. , Keane Susan P. 
Published: October 2009

AbstractEarly antisocial behavior has its origins in childhood behavior problems, particularly those characterized by aggressive and destructive behavior. Deficits in self-regulation across multiple domains of functioning, from the physiological to the cognitive, are associated with early behavior problems, and may place children at greater risk for the development of later antisocial behavior. Data are presented from a longitudinal study of early self-regulation and behavior problems, the RIGHT Track Research Project, demonstrating that children at greatest risk for early and persistent problem behavior display patterns of physiological and emotional regulation deficits early in life. Parenting behavior and functioning have also been examined as predictors of trajectories of early problem behavior, and some data support the interaction of parenting and self-regulation as significant predictors of patterns of problematic behavior and ongoing problems with the regulation of affect. Peer relationships also affect and are affected by early self-regulation skills, and both may play a role in academic performance and subsequent school success. These data provide evidence that the social contexts of early family and peer relationships are important moderators of the more proximal mechanism of self-regulation, and both types of processes, social and biobehavioral, are likely implicated in early antisocial tendencies. Implications of these findings on self-regulation and early behavior problems are discussed in terms of future research and treatment approaches.
The stability of psychopathy across adolescence
Authors: Lynam Donald R. , Charnigo Richard , Moffitt Terrie E. , Raine Adrian , Loeber Rolf , Stouthamer-Loeber Magda 
Published: October 2009

AbstractThe current diagnostic system suggests that personality disorder categories be applied to children and adolescents in rare circumstances because of expected changes in personality pathology across development. The present study examined the stability in personality pathology, specifically psychopathy, across childhood and adolescence. Using a short form of the CPS and mixed models incorporating fixed and random effects, we examined the reliability, individual stability, mean-level stability, and predictive utility of juvenile psychopathy as a function of age (i.e., from 7 to 17 years old) in over 1,500 boys from the three cohorts of the Pittsburgh Youth Study. If adolescent development contributes to instability in personality pathology, large age-related fluctuations in reliability, stability, and predictive utility should be observed, particularly in the latter part of adolescence when normative changes are hypothesized to influence levels of psychopathy. Such fluctuations were not observed. In general, juvenile psychopathy could be reliably assessed beginning in childhood, was fairly stable across short and long intervals, showed little mean-level fluctuation, and predicted delinquency across adolescence. These results suggest that concerns about large changes in personality pathology across childhood and adolescence may be overstated. Implications and future directions are discussed.