bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Synthesis of Novel Tricyclic 4‐Chloro‐7,8,10,11‐tetrahydro‐5H‐benzo[e]pyrimido[4,5‐b] [1,4]diazepin‐9(6H)‐ones.
Authors: Xiang Jinbao , Zheng Lianyou , Zhu Tong , Dang Qun , Bai Xu 
Published: December 2010

AbstractThe novel title heterocyclic scaffold is prepared efficiently from N‐substituted pyrimidinediamines and aldehydes.
ChemInform Abstract: Chemoselective and Regiospecific Suzuki Coupling on a Multisubstituted sp3‐Carbon in 1,1‐Diborylalkanes at Room Temperature.
Authors: Endo Kohei , Ohkubo Takahiro , Hirokami Munenao , Shibata Takanori 
Published: December 2010

AbstractSubstrates bearing a 1,1‐diboryl moiety react readily with various aryl halides to produce monoborylated products.
ChemInform Abstract: Three‐Component Synthesis of 2‐Oxoindolin‐3‐ylphosphonates
Authors: Shakibaei Ghazaleh Imani , Feiz Afsaneh , Ghahremanzadeh Ramin , Bazgir Ayoob 
Published: December 2010

Abstractand related acenaphthylenyl phosphonates (VI) under catalyst‐ and solvent‐free conditions
ChemInform Abstract: α‐Selective Ni‐Catalyzed Hydroalumination of Aryl‐ and Alkyl‐Substituted Terminal Alkynes: Practical Syntheses of Internal Vinyl Aluminums, Halides, or Boronates.
Authors: Gao Fang , Hoveyda Amir H. 
Published: December 2010

AbstractIn dependence of the nickel catalyst used, products of α‐ or β‐alumination are available in a completely selective manner.
ChemInform Abstract: Synthesis of Novel Diphenylamine‐Based Fluorescent Styryl Colorants and Study of Their Thermal, Photophysical, and Electrochemical Properties.
Authors: Sonawane Yogesh A. , Rajule Rajkumar N. , Shankarling Ganapati S. 
Published: December 2010

AbstractNovel “Y”‐shaped chromophores (I) and (II), which are soluble in common organic solvents are synthesized as (E)‐isomers by the classical Knoevenagel condensation.
ChemInform Abstract: Synthesis and Structure—Activity Relationships of Sinenxan A Derivatives as Multidrug Resistance Reversal Agents.
Authors: Huang Meng , Zhao Xin , Zhang Meng , Gu Jun , Chen Xiaoguang , Yin Dali 
Published: December 2010

AbstractTwo types of sinenxan A derivatives are synthesized and evaluated for their in vitro multidrug resistant reversal activities.
ChemInform Abstract: Functionalization of Peptides and Proteins by Mukaiyama Aldol Reaction.
Authors: Alam Jenefer , Keller Thomas H. , Loh Teck‐Peng 
Published: December 2010

AbstractAldol reaction of peptide aldehydes with a variety of ketene acetals is carried out in water without catalyst and affords the aldol products in modest yields and stereoselectivities.
ChemInform Abstract: Short and Straightforward Total Synthesis of Ammosamide B.
Authors: Wu Qian , Jiao Xiaozhen , Wang Liping , Xiao Qiong , Liu Xiaoyu , Xie Ping 
Published: December 2010

AbstractThe Doebner—Miller reaction of 1,3‐diamino‐4,6‐dinitrobenzene with diester (II) is the key step in the preparation of the anticancer title compound (IV).
ChemInform Abstract: Structures of New Erythrinan Alkaloids and Nitric Oxide Production Inhibitors from Erythrina crista‐galli.
Authors: Ozawa Masaaki , Kawamata Shunsuke , Etoh Tadahiro , Hayashi Masahiko , Komiyama Kanki , Kishida Akio , Kuroda Chiaki , Ohsaki Ayumi 
Published: December 2010

AbstractIn Brazil, the bark of the title tree is used for the treatment of rheumatism and hepatitis as well as for sedation and hypnogenesis.
ChemInform Abstract: Cucullamide, a New Putrescine Bisamide from Amoora cucullata.
Authors: Abdelfattah Mohamed Saleh , Toume Kazufumi , Ahmed Firoj , Sadhu Samir Kumar , Ishibashi Masami 
Published: December 2010

AbstractCucullamide (I) is isolated from the leaves of the title tree, which has been used in the Southeast Asian folk medicine for the treatment of inflammation, marrow and diarrhea.
ChemInform Abstract: Formal Synthesis of Platencin.
Authors: Li Pingfan , Yamamoto Hisashi 
Published: December 2010

AbstractA facile formal synthesis of platencin is developed involving the Lewis acid catalyzed tropone Diels—Alder reaction [→(III)] and the amino acid salt catalyzed intramolecular Robinson annulation of aldehyde (VIII) as the key steps.
ChemInform Abstract: Prenylflavonoids from Glycyrrhiza uralensis and Their Protein Tyrosine Phosphatase‐1B Inhibitory Activities.
Authors: Li Songpei , Li Wei , Wang Yinghua , Asada Yoshihisa , Koike Kazuo 
Published: December 2010

AbstractTwo new compounds, glycybenzofuran (I) and cyclolicocoumarone (II), are isolated together with 10 known flavonoids from the roots of Glycyrrhiza uralensis, a traditional chinese medicine.
ChemInform Abstract: A New Angucycline and a New Butenolide Isolated from Lichen‐Derived Streptomyces spp.
Authors: Motohashi Keiichiro , Takagi Motoki , Yamamura Hideki , Hayakawa Masayuki , Shin‐ya Kazuo 
Published: December 2010

AbstractThe 1,1‐dichlorocyclopropane‐containing angucycline, JBIR‐88 (I) and the butenolide, JBIR‐29 (II), are isolated from the fermentation broths of two lichen‐derived actinomycetes.
Gene Expression Programing for Estimating Suspended Sediment Yield in Middle Euphrates Basin, Turkey
Authors: Guven Aytac , Talu Necip Ersin 
Published: December 2010

AbstractGene expression programing (GEP) is used to estimate the suspended sediment yield (SSY) in Euphrates River. SSY is considered to be a function of (i) discharge and (ii) time‐lagged discharge and SSY. The proposed models were trained to extrapolate natural stream data collected from five stations in Middle Euphrates Basin. A detailed sensitivity analysis is done to select the time‐lagged discharge and sediment yield variables. GEP implicitly evaluates the contribution of each independent variable on the fitness of candidate solution and eliminates the variable having no contribution. In this study, all input variables are observed to be included in the proposed GEP models, which prove the significance of each variable. Also, standard and modified sediment rating curves and regression‐based formulae are developed for the five stations. In verification, the estimations of GEP formulae agree well with the measured ones. The GEP models are evaluated by the results of the rating curves and regression formulae. In general, the GEP formulae give better results compared to the rating curves and regression‐based formulae.
Cultural variability in expressed emotion among families of adolescents with anorexia nervosa
Authors: Hoste Renee Rienecke , Labuschagne Zandre , Lock James , Le Grange Daniel 
Published: December 2010

AbstractObjective:To examine the cultural variability in Expressed Emotion (EE) among families of white and ethnic minority adolescents with anorexia nervosa (AN).Method:One‐hundred and eighty‐nine AN patients and their parents completed the Eating Disorder Examination and the Structured Clinical Family Interview, from which EE ratings were made.Results:No differences were found in the number of white and minority families classified as high EE. White families were higher on warmth (W) and tended to be higher on positive remarks (PR) than minority families. High EE was associated with a longer duration of illness, but was not related to eating disorder pathology.Discussion:Few differences were found between white and ethnic minority families on the EE dimensions of CC, hostility (H), or EOI. Differences between families on W and PR, however, may have important treatment implications. © 2010 by Wiley Periodicals, Inc. (Int J Eat Disord 2012)
Molecular structure of the Mycobacterium tuberculosis virulence factor, mycolic acid, determines the elicited inflammatory pattern
Authors: Vander Beken Seppe , Al Dulayymi Juma'a R. , Naessens Thomas , Koza Gani , Maza‐Iglesias Max , Rowles Richard , Theunissen Cornelia , De Medts Jelle , Lanckacker Ellen , Baird Mark S. , Grooten Johan 
Published: December 2010

AbstractMycolic acids (MAs) occur in the cell wall of Mycobacterium tuberculosis as variable mixtures of different classes and chain lengths. Here, we address the relationship between the structure and its inflammatory function of this virulence factor using single synthetic MA isomers, differing in oxygenation class and cis‐ versus α‐methyl‐trans proximal cyclopropane orientation. Analysis of bronchoalveolar inflammation, lung histopathology and alveolar macrophage transcription revealed a strong dependence on these meromycolic chemistries of mouse pulmonary inflammation in response to intratracheal treatments with MAs. Whereas α‐MA was inert, oxygenated methoxy‐ and keto‐MA with cis‐cyclopropane stereochemistry elicited solid to mild inflammatory responses respectively. In trans‐cyclopropane orientation, methoxy‐MA partially lost its inflammatory activity and keto‐MA exerted anti‐inflammatory alternative activation of alveolar macrophages and counteracted cis‐methoxy‐MA induced airway inflammation. The differential innate immune activities of MAs demonstrated here, dependent on oxygenation class and cis versus α‐methyl‐trans cyclopropane chemistry, identify a novel means for M. tuberculosis to steer host immune responses during infection.
PdII‐Promoted Single‐Pot Template Transformations of Benzonitriles, Cyanoguanidine and Sodium Dicyanamide with the Formation of Symmetrical and Asymmetrical (1,3,5‐Triazapentadienate)palladium(II) Complexes
Authors: Kopylovich Maximilian N. , Lasri Jamal , Guedes da Silva M. Fátima C. , Pombeiro Armando J. L. 
Published: December 2010

AbstractTreatment of benzonitriles 4‐XC6H4CN (1) [X = H (1a), F (1b), Cl (1c), Br (1d), I (1e)] with an excess of 2‐butanone oxime (Me)(Et)C=NOH (as a reagent and solvent) in the presence of PdCl2 at 100 °C for 12 h affords the symmetrical cationic 2,4‐diaryl‐1,3,5‐triazapentadiene (Htap) palladium(II) complexes [Pd(Htap)2]Cl2 (2′) [Htap = HN=C(4‐XC6H4)NHC(4‐XC6H4)=NH]. Recrystallization of 2′ from MeOH/CHCl3 with two equivalents of n‐propylamine gives the corresponding neutral triazapentadienate (tap) complexes [Pd(tap)2] (2) [tap = HN=C(4‐XC6H4)NC(4‐XC6H4)=NH; X = H (2a), F (2b), Cl (2c), Br (2d), I (2e)] in good yields. When cyanoguanidine, HN=C(NH2)N(H)C≡N (3), or sodium dicyanamide NaN(C≡N)2 (5) are treated with an excess of primary alcohols, ROH [R = Me, Et, nPr, nBu or (CH2)2OMe] in the presence of PdCl2, while being heated for 12 h, the corresponding asymmetrical 2‐amino‐4‐alkoxy‐1,3,5‐triazapentadienate‐PdII complexes [Pd{HN=C(NH2)NC(OR)=NH}2] (4) [R = Me (4a), Et (4b), nPr (4c), nBu (4d)] or the symmetrical 2,4‐dialkoxy‐1,3,5‐triazapentadienate‐PdII complexes [Pd{HN=C(OR)NC(OR)=NH}2] (6) [R = Me (6a), Et (6b), nPr (6c), (CH2)2OMe (6d)], respectively, are formed and isolated as a mixture of isomers in good yields. All these compounds have been characterized by IR, 1H and 13C NMR spectroscopy, ESI‐MS, elemental analyses and, in the case of 2c, by XRD.
Pharmacokinetics and tissue distribution of vinorelbine delivered in parenteral lipid emulsion
Authors: Su Min , Zhao Mingming , Luo Yanfei , Lin Xia , Xu Lishuang , He Haibing , Tang Xing 
Published: December 2010

AbstractThe pharmacokinetics and biodistribution of vinorelbine (VRB) delivered in a parenteral lipid emulsion (VLE) were evaluated, and compared with that of a commercial vinorelbine injectable solution (Navelbine® i.v., VS). After intravenous administration to rats at doses of 2.25, 4.5, and 9 mg/kg, the AUC0–24 h was significantly different (1.15 ± 0.27, 2.65 ± 0.82, and 8.18 ± 1.10 mg/L/h for 2.25, 4.5, and 9 mg/kg, respectively), other pharmacokinetic parameters of VLE, such as the Cmax, CL, and Vss, were also dependent on the dose of VLE. The pharmacokinetics of VLE in rats was dose‐dependent in the dosage range of 2.25–9 mg/kg. VLE exhibited significantly higher VRB concentration than that of VS at the initial time points, it also produced a higher AUC0–24 h, MRT and lower CL in comparison with VS. In beagle dogs, VLE exhibited pharmacokinetic bioequivalence to VS. The tissue distribution in mice of VLE was modified compared to VS, the AUC0–48 h of VLE was grater in the liver, spleen, kidney and small intestine, but a little lower in the heart and lung.Practical applications: To reduce the severe local venous irritation of vinorelbine (VRB) at the aim of improve patient compliance, a parenteral vinorelbine loaded lipid emulsion (VLE) has been developed, and then systematical preclinical evaluations have been done. The pharmacokinetics and tissue distribution study reported here are part of the preclinical evaluation. VLE exhibited non‐linear relationship between dose and AUC0–24 h after single intravenous dose (at doses of 2.25, 4.5, and 9 mg/kg) to rats. Pharmacokinetic bioequivalence between VLE and VS was found after single intravenous infusion administration a dose of 1.33 mg/kg to beagle dogs. Tissue distribution results showed that the AUC0–48 h of VLE was grater in the liver, spleen, kidney, and small intestine, but a little lower in the heart and lung. These results could provide information for the further pharmacodynamics and pharmacology study, and finally for clinical use of VLE.
N‐Benzyl‐2,3‐trans‐Carbamate‐Bearing Glycosyl Donors for 1,2‐cis‐Selective Glycosylation Reactions
Authors: Manabe Shino , Ishii Kazuyuki , Ito Yukishige 
Published: December 2010

AbstractGlycosyl donors for the preparation of 1,2‐cis glycosides of amino sugars have been developed. The 2,3‐trans‐cyclic‐carbamate‐carrying glycosyl donors were readily prepared from the corresponding known trichloroethyl carbamate protected amino sugars under standard hydroxy group benzylation conditions. The donors exhibit high 1,2‐cis stereoselectivity towards secondary hydroxy group substrates. In the case of primary hydroxy acceptors, high stereoselectivities were achieved with the aid of the dioxane effect. After glycosylation, the carbamate was removed under alkaline conditions. Importantly, these glycosyl donors can be used in polymer‐supported and solid‐phase synthesis.
Mechanism of the Isotopic Exchange Reaction of the 5‐H Hydrogen of Uracil Derivatives in Water and Nonprotic Solvents
Authors: Dračínský Martin , Jansa Petr , Chocholoušová Jana , Vacek Jaroslav , Kovačková Soňa , Holý Antonín 
Published: December 2010

AbstractThe mechanism of the isotopic exchange reaction of the 5‐H hydrogen of uracil and its methyl derivatives in water and organic solvents has been studied. The key intermediate of the reaction is a C‐5 tautomer of uracil in which the carbon atom at the 5‐position has two hydrogen atoms, its hybridization is changed from sp2 to sp3, and the aromaticity of the pyrimidine ring is lost. We have used 1H NMR spectroscopy to follow the kinetics of the hydrogen/deuterium exchange reaction. In aqueous media a general base catalysis was observed and for exchange in organic solvents we have proposed a reaction mechanism that involves the participation of solvent molecules. The reaction rates determined by NMR can be rationalized by density functional computations. We have shown that the hydrogen‐to‐deuterium exchange reaction is much faster in some suitable nucleophilic solvents than in water. These findings could be used for the tritium labeling of pyrimidine nucleic acid bases.
Consecutive One‐Pot Sonogashira–Glaser Coupling Sequence – Direct Preparation of Symmetrical Diynes by Sequential Pd/Cu Catalysis
Authors: Merkul Eugen , Urselmann Dominik , Müller Thomas J. J. 
Published: December 2010

AbstractSonogashira coupling and the catalytic Glaser coupling are both catalyzed by the Pd–Cu complex couple and can be concatenated to a consecutive sequentially Pd/Cu‐catalyzed process in a one‐pot fashion, and air oxygen serves as the only oxidant in the second step. In a pseudo‐four‐component synthesis, a broad variety of symmetrically substituted 1,4‐bis(hetero)aryl‐1,3‐butadiynes are obtained in good to excellent yields. Interestingly, the presence of iodide ions has been found to be advantageous over other halides to trigger the Pd/Cu‐catalyzed Glaser step, and Pd and Cu species, as well as triethylamine as a base, are prerequisite for both couplings, which proceed with higher efficiency if performed in a one‐pot sequence.
Cognitive functioning in individuals with severe compulsive hoarding behaviors and late life depression
Authors: Mackin R. Scott , Areán Patricia A. , Delucchi Kevin L. , Mathews Carol A. 
Published: December 2010

AbstractObjectivesThe cognitive characteristics of individuals with severe compulsive hoarding behaviors (SCH) are not well understood and existing studies have largely focused on individuals with SCH and concurrent anxiety disorders. The present study was conducted to evaluate the frequency with which SCH co‐occurs with LLD and to compare the cognitive characteristics of individuals with late life depression and concurrent SCH (LLD + SCH) to that of LLD individuals without SCH (LLD).MethodsParticipants included 52 LLD individuals who received psychiatric and neuropsychological evaluations as part of a larger study. Cognitive performance on measures of memory, attention, language, information processing speed, and categorization/problem solving ability was evaluated for each participant using standard neuropsychological measures. Measures of depression and anxiety symptom severity were also obtained.ResultsSeven (13%) of the 52 LLD participants reported significant SCH behaviors. The two groups (LLD + SCH; LLD) did not differ with respect to demographic characteristics or severity of depression or anxiety. Individuals with LLD + SCH demonstrated significantly poorer performance on two measures of categorization/problem solving ability relative to individuals with isolated LLD. Clinically significant impairments on measures of categorization ability, information processing speed, and verbal memory were more common for SCH + LLD than LLD participants.ConclusionsOur preliminary results suggest that SCH behaviors in LLD are associated with specific aspects of executive dysfunction characterized by categorization deficits and to a lesser extent information processing speed and verbal memory deficits. Further study of cognitive functioning in older adults with LLD and SCH may clarify the underlying cognitive characteristics of the SCH syndrome. Copyright © 2010 John Wiley & Sons, Ltd.
Interim follow‐up of a randomized controlled trial comparing Chinese style mind body (Tai Chi) and stretching exercises on cognitive function in subjects at risk of progressive cognitive decline
Authors: Lam Linda C. W. , Chau Rachel C. M. , Wong Billy M. L. , Fung Ada W. T. , Lui Victor W. C. , Tam Cindy C. W. , Leung Grace T. Y. , Kwok Timothy C. Y. , Chiu Helen F. K. , Ng Sammy , Chan W. M. 
Published: December 2010

AbstractObjectivesWe reported the interim findings of a randomized controlled trial (RCT) to examine the effects of a mind body physical exercise (Tai Chi) on cognitive function in Chinese subjects at risk of cognitive decline.Subjects389 Chinese older persons with either a Clinical Dementia Rating (CDR 0.5) or amnestic‐MCI participated in an exercise program. The exercise intervention lasted for 1 year; 171 subjects were trained with 24 forms simplified Tai Chi (Intervention, I) and 218 were trained with stretching and toning exercise (Control, C). The exercise comprised of advised exercise sessions of at least three times per week.ResultsAt 5th months (2 months after completion of training), both I and C subjects showed an improvement in global cognitive function, delayed recall and subjective cognitive complaints (paired t‐tests, p < 0.05). Improvements in visual spans and CDR sum of boxes scores were observed in I group (paired t‐tests, p < 0.001). Three (2.2%) and 21(10.8%) subjects from the I and C groups progressed to dementia (Pearson chi square = 8.71, OR = 5.34, 95% CI 1.56–18.29). Logistic regression analysis controlled for baseline group differences in education and cognitive function suggested I group was associated with stable CDR (OR = 0.14, 95%CI = 0.03–0.71, p = 0.02).ConclusionsOur interim findings showed that Chinese style mind body (Tai Chi) exercise may offer specific benefits to cognition, potential clinical interests should be further explored with longer observation period. Copyright © 2010 John Wiley & Sons, Ltd.
Religious and spiritual beliefs in outpatients suffering from Parkinson Disease
Authors: Giaquinto S. , Bruti L. , Dall'Armi V. , Palma E. , Spiridigliozzi C. 
Published: December 2010

AbstractObjectivePersonality changes are known to occur in idiopathic Parkinson's Disease (PD). The aim of the study was to evaluate whether religious and spiritual beliefs in PD patients are different from age‐matched controls.DesignEighty‐three PD participants, 79 hypertensive individuals not affected by PD and 88 healthy subjects participated to a cross‐sectional study. The Royal Free Interview (RFI) was used to evaluate participants' beliefs. The Hospital Anxiety and Depression Scale (HADS) was applied to monitor emotional distress.ResultsThere was no statistical evidence of a difference between PD participants and the two control groups, the only exception being observed between the left PD onset group and the controls, where the total RFI score was about 5 points higher (t‐test: p = 0.0273). RFI total score was uncorrelated with age, severity of illness and depression, but was strongly dependent on the type of beliefs. The percentage of PD participants suffering from anxiety and depression was high (right onset: 54.8%; left onset: 68.6%), while only 15.2% of the hypertensive participants, and none of the healthy controls, had a HADS score above 10 points. Total RFI score was higher in women.ConclusionPD participants maintain their Faith in spite of the disease severity. Differences are found between right and left onset of PD. The possible beneficial effect of religious coping is discussed. Copyright © 2010 John Wiley & Sons, Ltd.
Social capital and self‐rated health in Argentina
Authors: Ronconi Lucas , Brown Timothy T. , Scheffler Richard M. 
Published: December 2010

SUMMARYThe potential link between social capital and health suggests important pathways by which health may be improved. We examine this relationship using a unique data set from Argentina. This national survey allows us to determine whether the relationships between social capital and health that have been found in the US and Europe also apply to countries in South America (Argentina is the second‐largest country in South America with a population of approximately 40 million). We estimate a causal effect of individual‐level social capital on health using a measure of informal social interactions as our measure of social capital. Using information about access to public transportation as instrumental variables, we find that both men and women with higher levels of social capital report better health. Copyright © 2010 John Wiley & Sons, Ltd.
Gene expression of markers of osteogenic differentiation of human mesenchymal cells on collagen I‐modified microrough titanium surfaces
Authors: Morra M. , Cassinelli C. , Cascardo G. , Bollati D. , Baena R. Rodriguez y 
Published: December 2010

AbstractMicrorough, doubly acid etched titanium surfaces (Ti) were further modified by amination and covalent coupling of fibrillar collagen type I (ColTi). Human Mesenchymal Cells (HMC) adhesion and growth, and relevant osteogenic differentiation in nonosteogenic (basal) medium were evaluated by fluorescence microscopy, scanning electron microscopy, and RT‐PCR for a three‐week period. Results show strongly enhanced HMC adhesion and cell density at short experimental time on ColTi, together with complete spreading of the cell body over the microrough surface topography. RT‐PCR analysis of several genes involved in osteogenesis indicate, since the first week of culturing, significant progression of HMC on ColTi along the osteogenic pathway. These results indicate that the adopted process of surface immobilization of collagen, mandatory to impart collagenase resistance in implant sites, does not impair biospecific interactions between HMC and collagen. Thus, it is possible to upgrade properties arising from the control of Ti surfaces topography by surface‐chemistry driven enhanced recruitment of precursor osteogenic cells and pro‐osteogenic stimula. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2011.