bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structure, timing and morphological signature of hidden reverse basement faults in the Fars Arc of the Zagros (Iran)
Authors: Leturmy Pascale , Molinaro Matteo , de Lamotte Dominique Frizon 
Published: June 2010

Abstract
In the Zagros Fold–Thrust Belt (ZFTB) of Iran it is firmly established that the basement is involved in the deformation. The strongest line of evidence for this assertion comes from the relatively intense mid-crustal seismic activity. On one hand, the main basement structures such as the Main Zagros Fault (MZT) and High Zagros Fault (HZF) reach the surface and are therefore well identified. On the other hand, basement faults south of the HZF are hidden by sedimentary cover and their location is uncertain. In the Eastern Zagros, basement control on surface structures occurred only at a late stage of the tectonic evolution. In other words, the current thick-skinned style of Zagros deformation succeeded a more general thin-skinned phase of orogeny. This chronology is particularly well illustrated by spectacular interference patterns, in which early detachment folds are cut by late oblique basement faults. We present a combined morphological and structural analysis of such structures, and we explore their impact on the river network. We confirm that basement involvement occurred at a late stage of deformation and we show that thick-skinned deformation progressively propagated towards the foreland. An overview of basement steps throughout the Zagros based on published cross-sections allows us to conclude that although basement deformation is concentrated on two major faults in the Central Zagros, it is distributed on several segmented faults in the Fars Arc. This segmentation increases to the SE towards the so-called Oman line and the transition to the Makran accretionary prism.
A study of fold characteristics and deformation style using the evolution of the land surface: Zagros Simply Folded Belt, Iran
Authors: Burberry C. M. , Cosgrove J. W. , Liu J.-G. 
Published: June 2010

Abstract
Deformation styles within a fold–thrust belt can be understood in terms of the spatial organization and geometry of the fold structures. In young fold–thrust belts such as the Zagros, this geometry is reflected topographically by concordant landform morphology. Thus, the distribution of deformation structures can be characterized using satellite image analysis, digital elevation models, the drainage network and geomorphological indicators. The two distinct fold types considered in this study (fault-bend folds and detachment folds) both trending NW–SE, interact with streams flowing NE–SW from the High Zagros Mountains into the Persian Gulf. Multiple abandoned stream channels cross fault-bend folds related to deep-seated thrust faults. In contrast, detachment folds, which propagate laterally relatively rapidly, are characterized by diverted major stream channels and dendritic minor channels at the fold tips. Thus these two fold types can be differentiated on the basis of their geometry (fault-bend folds, being long, linear and asymmetrical, can be distinguished from detachment folds, which tend to be shorter and symmetrical) and on their associated geomorphological structures. The spatial organization of these structures in the Zagros Simply Folded Belt indicates that deformation is the result of the interaction of footwall collapse and the associated formation of long, linear fault-bend folds, and serial folding characterized by relatively short periclinal folds. Footwall collapse occurs first, followed by serial folding to the NE (i.e. in the hanging wall of the fault-bend folds), often on higher detachments within the sediment pile.
The chaos of the internet as an external brain; and more
Authors: Linden Greg , Chi Ed H. , Guzdial Mark 
Published: June 2010

The
Communications
Web site, http://cacm.acm.org, features more than a dozen bloggers in the BLOG@CACM community. In each issue of
Communications
, we'll publish selected posts or excerpts.

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Greg Linden writes about the Internet as a peripheral resource; Ed H. Chi discusses lessons learned from the DARPA Network Challenge; and Mark Guzdial asks if there are too many IT workers or too many IT jobs.
Future Tense: I, myself and e-myself
Authors: Rhee Cheul , Sanders G. Lawrence , Simpson Natalie C. 
Published: June 2010

Introduction

The Internet has revolutionized the manner in which people interact. Once regarded as merely a convenient platform for the collection and dissemination of information, the Internet is increasingly used for intensely personal and creative purposes. Web 2.0 applications supporting Web-based social networking through blogs, wikis and folksonomies have proven potent in changing users' perception and use of the Internet.
Using the Internet has thus acquired a new and more personal dimension. People increasingly rely on it to provide them with societal and communal structures that were hitherto the remit of their families and work-groups. Internet users may either own their own Web space or use facilities provided by an online host, increasingly personalizing these virtual properties. While residing in their virtual places, users socialize, share ideas, and attempt to personalize their virtual property.
The search for a suitable online residence entails significant costs in terms of time and effort that are commensurate with the anticipated gain. The process of settling down in a virtual place includes searching for communities (or services), creating new online IDs, managing profiles judiciously, and adapting to new environments. Settling-in increases users' switching costs and this locks the users into a virtual place. The more time and effort a user spends on a specific place, the greater the cost and the disincentive of switching to another place. A primary goal of Web 2.0 application providers is to retain membership in their communities. Understanding the psychological dynamics of online behaviors is an essential part of identifying and retaining membership in online communities.
Although it is useful to understand the psychological underpinning of online users, the adoption of psychological theories and instances should be performed with caution and with due regard to applicability. Many Web developers start with the premise that an individual's perceptions, thoughts and online behaviors are similar to their personality in the real world. However, if this premise itself is wrong - that is, if an individual becomes a different person when online, then our theories along with our business strategies may require modification. It is our position that study of the development of the virtual personality is vital because human beings perceive, think, and behave differently when they are online.
StReBio'09
Authors: Ramon Jan , Costa Fabrizio , Florencio Christophe Costa , Kok Joost 
Published: June 2010

Bioinformatics is an application domain where information is naturally represented in terms of relations between heterogenous objects. Modern experimentation and data acquisition techniques allow the study of complex interactions in biological systems. This raises interesting challenges for machine learning and data mining researchers, as the amount of data is huge, some information can not be observed, and measurements may be noisy.
This report presents a review on the ACM SIGKDD 2009 Workshop on Statistical Relational Learning and Mining in Bioinformatics (StReBio'09) which was held in Paris on June 28th, 2009. The aim of this workshop was to provide a forum to share challenges, results and ideas at the frontier between the field of statistical relational learning and the field of bioinformatics.
Electrophysiological Chronometry of Semantic Context Effects in Language Production
Authors: Aristei Sabrina , Melinger Alissa , Abdel Rahman Rasha 
Published: June 2010

Abstract
In this study, we investigated semantic context effects in language production with event-related brain potentials, extracted from the ongoing EEG recorded during overt speech production. We combined the picture–word interference paradigm and the semantic blocking paradigm to investigate the temporal dynamics and functional loci of semantic facilitation and interference effects. Objects were named in the context of semantically homogeneous blocks consisting of related objects and heterogeneous blocks consisting of unrelated objects. In each blocking condition, semantically related and unrelated distractor words were presented. Results show that classic patterns of semantically induced facilitation and interference effects in RTs can be directly related to ERP modulations located at temporal and frontal sites, starting at about 200 msec. Results also suggest that the processes associated with semantic facilitation and interference effects (i.e., conceptual and lexical processing) are highly interactive and coincide in time. Implications for the use of event-related brain potentials in speech production research and implications for current models of speech production are discussed.
Enhanced Cortical Connectivity in Absolute Pitch Musicians: A Model for Local Hyperconnectivity
Authors: Loui Psyche , Li H. Charles , Hohmann Anja , Schlaug Gottfried 
Published: June 2010

AbstractConnectivity in the human brain has received increased scientific interest in recent years. Although connection disorders can affect perception, production, learning, and memory, few studies have associated brain connectivity with graded variations in human behavior, especially among normal individuals. One group of normal individuals who possess unique characteristics in both behavior and brain structure is absolute pitch (AP) musicians, who can name the appropriate pitch class of any given tone without a reference. Using diffusion tensor imaging and tractography, we observed hyperconnectivity in bilateral superior temporal lobe structures linked to AP possession. Furthermore, volume of tracts connecting left superior temporal gyrus to left middle temporal gyrus predicted AP performance. These findings extend previous reports of exaggerated temporal lobe asymmetry, may explain the higher incidence of AP in special populations, and may provide a model for understanding the heightened connectivity that is thought to underlie savant skills and cases of exceptional creativity.
The Matrix of Despair: From Despair to Desire Through Dialogue
Authors: Tubert-Oklander Juan 
Published: June 2010

There are two paradigms in analysis: an individual paradigm , in orthodox psychoanalytic theory; and a collective paradigm , that of group analysis, which constructs new theories stemming from the group analytic experience. The group is conceived as a network of multiple relations, and individuals are its nodal points. Individual human beings are contained and shaped by its matrix, and they develop an unconscious object relation with it. Despair is a painful and disrupting experience that ensues when there is a severe fracture in the relations that form the matrix. Group analysis explores the relation between the subjectivity of the parties and the wider contexts of their existence, by means of interpretation and group discussion of the social and political dimension, as well as personal and interpersonal conflicts. A clinical vignette from a group illustrates the evolution from despair and impotence to active desire and hope , mediated by a free-floating and reflective dialogue , which includes not only argumentation and exchange of information, but also mutual interaction and emotional relations.
Pulmonary hypertension in patients with chronic myeloproliferative disorders
Authors: Adir Y. , Humbert M. 
Published: June 2010

Pulmonary hypertension (PH) is a severe haemodynamic disorder in which the pulmonary artery pressure is persistently elevated, leading to right-sided heart failure and death. Recently, chronic myeloproliferative diseases associated with pulmonary hypertension were included in the group 5 category, corresponding to PH for which the aetiology is unclear and/or multifactorial.In this review we will describe the distinct forms of PH in the context of the myeloproliferative diseases chronic thromboembolic pulmonary hypertension and pre-capillary PH mimicking pulmonary arterial hypertension. The epidemiology, mechanisms and treatment approaches will be discussed.
Retrosternal and pleural “bridging” fibrosis mimicking malignancy in a patient exposed to asbestos
Authors: Debray M-P. , Marchand-Adam S. , Soufan R. , Ostinelli J. , Brillet P-Y. , Schouman-Claeys E. , Crestani B. 
Published: June 2010

Mediastinal fibrosis is a rare, benign disorder characterised by proliferation of fibrous tissue within the mediastinum. It can present as diffuse mediastinal infiltration or, more frequently, as a localised soft tissue mass, usually in the right paratracheal or subcarinal areas. 18-fluorodeoxyglucose (18-FDG) positron emission tomography (PET) imaging has only been reported in a few case reports with variable aspects.Herein, we present an unusual pattern of mediastinal fibrosis, presenting as a thick retrosternal mass contiguous with pleural thickening. 18-FDG PET showed intensely increased uptake in the mass. Both the location of fibrosis and PET imaging were confusing with malignancy. Histopathological proof of benign fibrosis was obtained by surgery. The patient had been exposed to asbestos and the possible relationship of this particular pattern of fibrosis with asbestos exposure will be discussed.
Update on asthma control in five European countries: results of a 2008 survey
Authors: Demoly P. , Gueron B. , Annunziata K. , Adamek L. , Walters R. D. 
Published: June 2010

The 2006 European National Health and Wellness Survey (NHWS) showed that a large proportion of asthmatics had uncontrolled asthma. The current analysis estimated the prevalence of asthma and asthma control (Asthma Control Test™ (ACT); QualityMetric Inc., Lincoln, RI, USA) in five European countries using the 2008 NHWS. Health-related quality of life (HRQoL), using the Short Form-12 (SF-12) health survey, and work productivity/activity impairment were assessed.Of 3,619 respondents aged ≥18 yrs, the prevalence of self-reported physician diagnosis of asthma was 6.1% (15 million people); 56.6% of treated asthmatics were not well-controlled (NWC; ACT score ≤19). Individual components of the ACT showed that, compared with at least well-controlled patients (ALWC; ACT score ≥20), NWC patients had activity limitations at least some of the time (40.8%versus1.5%, p<0.001), were breathless ≥3 times per week (72.5%versus5.4%, p<0.001), suffered sleep difficulties due to asthma at least once per week (60.3%versus4.6%, p<0.001) and required rescue medication ≥2–3 times per week (77.4%versus15.9%, p<0.001). NWC patients had also received more healthcare contact in the past 6 months, including hospitalisation (17.4%versus9.9%, p<0.001). The SF-12 physical and mental summary scores were 7.46 and 4.73 points higher, respectively, for ALWC patients compared with NWC patients (p<0.001). ALWC patients reported less absenteeism (5.5%versus12.2%) and work impairment (15.4%versus30.0%) than NWC patients (both p<0.001).The proportion of asthmatics with NWC asthma has not improved since 2006. ALWC asthma is associated with a significant positive impact on healthcare resource use, HRQoL and work productivity.
Curcumin modulates dopaminergic receptor, CREB and phospholipase c gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats
Authors: Kumar T Peeyush , Antony Sherin , Gireesh G , George Naijil , Paulose CS 
Published: June 2010

Abstract
Curcumin, an active principle component in rhizome of Curcuma longa, has proved its merit for diabetes through its anti-oxidative and anti-inflammatory properties. This study aims at evaluating the effect of curcumin in modulating the altered dopaminergic receptors, CREB and phospholipase C in the cerebral cortex and cerebellum of STZ induced diabetic rats. Radioreceptor binding assays and gene expression was done in the cerebral cortex and cerebellum of male Wistar rats using specific ligands and probes. Total dopaminergic receptor binding parameter, Bmax showed an increase in cerebral cortex and decrease in the cerebellum of diabetic rats. Gene expression studies using real time PCR showed an increased expression of dopamine D1 and D2 receptor in the cerebral cortex of diabetic rats. In cerebellum dopamine D1 receptor was down regulated and D2 receptor showed an up regulation. Transcription factor CREB and phospholipase C showed a significant down regulation in cerebral cortex and cerebellum of diabetic rats. We report that curcumin supplementation reduces diabetes induced alteration of dopamine D1, D2 receptors, transcription factor CREB and phospholipase C to near control. Our results indicate that curcumin has a potential to regulate diabetes induced malfunctions of dopaminergic signalling, CREB and Phospholipase C expression in cerebral cortex and cerebellum and thereby improving the cognitive and emotional functions associated with these regions. Furthermore, in line with these studies an interaction between curcumin and dopaminergic receptors, CREB and phospholipase C is suggested, which attenuates the cortical and cerebellar dysfunction in diabetes. These results suggest that curcumin holds promise as an agent to prevent or treat CNS complications in diabetes.
Predicting the network of substrate-enzyme-product triads by combining compound similarity and functional domain composition
Authors: Chen Lei , Feng Kai-Yan , Cai Yu-Dong , Chou Kuo-Chen , Li Hai-Peng 
Published: June 2010

Abstract

Background
Metabolic pathway is a highly regulated network consisting of many metabolic reactions involving substrates, enzymes, and products, where substrates can be transformed into products with particular catalytic enzymes. Since experimental determination of the network of substrate-enzyme-product triad (whether the substrate can be transformed into the product with a given enzyme) is both time-consuming and expensive, it would be very useful to develop a computational approach for predicting the network of substrate-enzyme-product triads.

Results
A mathematical model for predicting the network of substrate-enzyme-product triads was developed. Meanwhile, a benchmark dataset was constructed that contains 744,192 substrate-enzyme-product triads, of which 14,592 are networking triads, and 729,600 are non-networking triads; i.e., the number of the negative triads was about 50 times the number of the positive triads. The molecular graph was introduced to calculate the similarity between the substrate compounds and between the product compounds, while the functional domain composition was introduced to calculate the similarity between enzyme molecules. The nearest neighbour algorithm was utilized as a prediction engine, in which a novel metric was introduced to measure the "nearness" between triads. To train and test the prediction engine, one tenth of the positive triads and one tenth of the negative triads were randomly picked from the benchmark dataset as the testing samples, while the remaining were used to train the prediction model. It was observed that the overall success rate in predicting the network for the testing samples was 98.71%, with 95.41% success rate for the 1,460 testing networking triads and 98.77% for the 72,960 testing non-networking triads.

Conclusions
It is quite promising and encouraged to use the molecular graph to calculate the similarity between compounds and use the functional domain composition to calculate the similarity between enzymes for studying the substrate-enzyme-product network system. The software is available upon request.
Dietary patterns associated with fall-related fracture in elderly Japanese: a population based prospective study
Authors: Monma Yasutake , Niu Kaijun , Iwasaki Koh , Tomita Naoki , Nakaya Naoki , Hozawa Atsushi , Kuriyama Shinichi , Takayama Shin , Seki Takashi , Takeda Takashi , Yaegashi Nobuo , Ebihara Satoru , Arai Hiroyuki , Nagatomi Ryoichi , Tsuji Ichiro 
Published: June 2010

Abstract

Background
Diet is considered an important factor for bone health, but is composed of a wide variety of foods containing complex combinations of nutrients. Therefore we investigated the relationship between dietary patterns and fall-related fractures in the elderly.

Methods
We designed a population-based prospective survey of 1178 elderly people in Japan in 2002. Dietary intake was assessed with a 75-item food frequency questionnaire (FFQ), from which dietary patterns were created by factor analysis from 27 food groups. The frequency of fall-related fracture was investigated based on insurance claim records from 2002 until 2006. The relationship between the incidence of fall-related fracture and modifiable factors, including dietary patterns, were examined. The Cox proportional hazards regression model was used to examine the relationships between dietary patterns and incidence of fall-related fracture with adjustment for age, gender, Body Mass Index (BMI) and energy intake.

Results
Among 877 participants who agreed to a 4 year follow-up, 28 suffered from a fall-related fracture. Three dietary patterns were identified: mainly vegetable, mainly meat and mainly traditional Japanese. The moderately confirmed (see statistical methods) groups with a Meat pattern showed a reduced risk of fall-related fracture (Hazard ratio = 0.36, 95% CI = 0.13 - 0.94) after adjustment for age, gender, BMI and energy intake. The Vegetable pattern showed a significant risk increase (Hazard ratio = 2.67, 95% CI = 1.03 - 6.90) after adjustment for age, gender and BMI. The Traditional Japanese pattern had no relationship to the risk of fall-related fracture.

Conclusions
The results of this study have the potential to reduce fall-related fracture risk in elderly Japanese. The results should be interpreted in light of the overall low meat intake of the Japanese population.
Inhibition of experimental lung metastasis by systemic lentiviral delivery of kallistatin
Authors: Shiau Ai-Li , Teo Min-Li , Chen Shin-Yao , Wang Chrong-Reen , Hsieh Jeng-Long , Chang Meng-Ya , Chang Chih-Jui , Chao Julie , Chao Lee , Wu Chao-Liang , Lee Che-Hsin 
Published: June 2010

Abstract

Background
Angiogenesis plays an important role in the development and progression of tumors. Kallistatin exerts anti-angiogenic and anti-inflammatory activities that may be effective in inhibiting tumor metastasis. We investigated the antitumor effect of lentivirus-mediated kallistatin gene transfer in a syngeneic murine tumor model.

Methods
Lentiviral vector encoding kallistatin (LV-Kallistatin) was constructed. The expression of kallistatin was verified by enzyme-linked immunosorbent assay (ELISA), and the bioactivity of kallistatin was determined by using cell proliferation, migration, and invasion assays. In addition, antitumor effects of LV-Kallistatin were evaluated by the intravenous injection of virus into tumor-bearing mice.

Results
The conditioned medium from LV-Kallistatin-treated cells inhibited the migration and proliferation of endothelial cells. Meanwhile, it also reduced the migration and invasion of tumor cells. In the experimental lung metastatic model, tumor-bearing mice receiving LV-Kallistatin had lower tumor nodules and longer survival than those receiving control virus or saline. Moreover, the microvessel densities, the levels of vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF)-α, and nuclear factor κB (NF-κB) transcriptional activity were reduced in the LV-Kallistatin-treated mice.

Conclusion
Results of this study showed that systemic administration of lentiviral vectors encoding kallistatin inhibited the growth of metastatic tumor and prolonged the survival of tumor-bearing mice. These results suggest that gene therapy using lentiviruses carrying the kallistatin gene, which exerts anti-angiogenic and anti-inflammatory activities, represents a promising strategy for the treatment of lung cancer.