bluuebunny/crossref_metadata_2025_split huggingface dataset:
Angiopoietin‐like 4 is upregulated by amphiregulin and activates cell proliferation and migration through p38 kinase in head and neck squamous cell carcinoma
Authors: Kumar Ajay , Asiedu Emmanuel , Hefni Eman , Armstrong Cheryl , Menon Deepak , Ma Tao , Sands Lauren , Mbadugha Eberechi , Sodhi Akrit , Schneider Abraham , Montaner Silvia 
Published: May 2024

AbstractBackgroundAngiopoietin‐like 4 is a molecular hallmark that correlates with the growth and metastasis of head and neck squamous cell carcinoma, one of the most prevalent cancers worldwide. However, the molecular mechanisms by which angiopoietin‐like 4 promotes head and neck squamous cell carcinoma tumorigenesis are unclear.MethodsUsing well‐characterized cell lines of head and neck squamous cell carcinoma development, including human normal oral keratinocytes, dysplastic oral keratinocytes, oral leukoplakia‐derived oral keratinocytes, and head and neck squamous cell carcinoma cell lines, HN13, HN6, HN4, HN12, and CAL27, we investigated the signaling pathways upstream and downstream of angiopoietin‐like 4‐induced head and neck squamous cell carcinoma tumorigenesis.ResultsWe found that both epidermal growth factor receptor ligands, epithelial growth factor, and amphiregulin led to angiopoietin‐like 4 upregulation in normal oral keratinocytes and dysplastic oral keratinocytes and cooperated with the activation of hypoxia‐inducible factor‐1 in this effect. Interestingly, amphiregulin and angiopoietin‐like 4 were increased in dysplastic oral keratinocytes and head and neck squamous cell carcinoma cell lines, and amphiregulin‐induced activation of cell proliferation was dependent on angiopoietin‐like 4. Although both p38 mitogen‐activated protein kinases (p38 MAPK) and protein kinase B (AKT) were activated by angiopoietin‐like 4, only pharmacological inhibition of p38 MAPK was sufficient to prevent head and neck squamous cell carcinoma cell proliferation and migration. We further observed that angiopoietin‐like 4 promoted the secretion of interleukin 11 (IL‐11), interleukin 12 (IL‐12), interleukin‐1 alpha (IL‐1α), vascular endothelial growth factor, platelet‐derived growth factor (PDGF), and tumour necrosis factor alpha (TNF‐α), cytokines and chemokines previously implicated in head and neck squamous cell carcinoma pathogenesis.ConclusionOur results demonstrate that angiopoietin‐like 4 is a downstream effector of amphiregulin and promotes head and neck squamous cell carcinoma development both through direct activation of p38 kinase as well as paracrine mechanisms.
Biomechanical Properties of Novel Porous Scaffold Core and Hollow Lateral Hole Pedicle Screws: A Comparative Study in Bama Pigs
Authors: Hu Yong , Chen Xijiong , Chu Zhentao , Luo Linwei , Gan Zhiwei , Zhong Jianbin , Yuan Zhenshan , Zhu Bingke , Dong Weixin 
Published: May 2024

ObjectiveScrew loosening is a common complication of internal fixation of pedicle screw. Therefore, the development of a pedicle screw with low loosening rate and high biosafety is of great clinical significance. This study aimed to investigate whether the application of a porous scaffold structure can improve the stability of pedicle screws by comparing the biomechanical properties of novel porous scaffold core pedicle screws (PSCPSs) with those of hollow lateral hole pedicle screws (HLHPSs) in a porcine lumbar spine.MethodsThirty‐two pedicle screws of both types were implanted bilaterally into the L1–4 vertebrae of four Bama pigs, with our newly designed PSCPSs on the right and HLHPSs on the left. All the Bama pigs were sacrificed 16 weeks postoperatively, and the lumbar spine was freed into individual vertebrae. Biomechanical properties of both the pedicle screws were evaluated using pull‐out tests, as well as cyclic bending and pull‐out tests, while the mechanical properties were assessed using three‐point bending tests. The data generated were statistically analyzed using paired‐sample t‐tests and two independent sample t‐tests.ResultsWe found that the maximal pull‐out forces before and after cyclic bending of the PSCPSs (1161.50 ± 337.98 N and 1075.25 ± 223.33 N) were significantly higher than those of the HLHPSs (948.38 ± 194.32 N and 807.13 ± 242.75 N) (p < 0.05, p < 0.05). In 800 cycles of the bending tests, neither PSCPS nor HLHPS showed loosening or visible detachment, but their maximal pull‐out forces after cyclic bending tests decreased compared to those in cycles without cyclic bending tests (7.43% and 14.89%, respectively), with no statistical significance (p > 0.05 and p > 0.05, respectively). Additionally, both screws buckled rather than broke in the three‐point bending tests, with no statistically significant differences between the maximal bending load and modulus of elasticity of the two screws (p > 0.05 and p > 0.05, respectively).ConclusionsCompared with the HLHPSs, the PSCPSs have greater pull‐out resistance and better fatigue tolerance with appropriate mechanical properties. Therefore, PSCPSs theoretically have significant potential for clinical applications in reducing the incidence of loosening after pedicle screw implantation.
The Effect of Clavicular Tunnel Position on Reduction Loss in Patients with Acute Acromioclavicular Joint Dislocations Operated with a Single‐Bundle Suspensory Loop Device
Authors: Senel Ahmet , Eren Murat , Batur Omer Cihan , Kaya Oguz , Sert Selman , Key Sefa 
Published: May 2024

ObjectiveThe treatment of acromioclavicular joint (ACJ) dislocations offers numerous options, and ongoing debates persist regarding their comparative effectiveness. Among these options, the suspensory loop device (SLD) is one of the most favored treatment modalities. Despite the observed high reduction loss rate associated with SLD, the treatment yields favorable clinical outcomes. This study aimed to investigate the clinical outcomes of patients with acute type 3 and 5 ACJ dislocations who underwent open and arthroscopic procedures using a single‐bundle SLD, and to evaluate the effect of clavicular tunnel position on reduction loss.MethodsThirty‐seven eligible patients diagnosed with acute type 3 and type 5 ACJ dislocation who underwent open and arthroscopic surgery with a single‐bundle SLD between January 2015 and March 2022 were evaluated retrospectively. Demographic data and radiological measurements including coracoclavicular (CC) interval, clavicle length (CL), and implant distance (ID) were recorded. The ID/CL ratio was calculated and a value between 0.17 and 0.24 was considered as “acceptable implant position”. Reduction loss and other complications were noted. Patients were divided into two groups: open (Group 1) and arthroscopic (Group 2). Constant Murray Score (CMS) and Visual Analog Scale (VAS) were used for clinical and functional outcomes. Non‐parametric tests were used for statistical analysis of variables.ResultsThe study included six females (16.2%) and 31 males (83.8%) with a mean age of 40.2 ± 14.7 years (range: 20–75). The mean follow‐up period was 22.3 ± 16.7 months (range: 6–72). The average time from trauma to surgery was 6.3 ± 5.3 days (range: 1–18). At the last follow‐up, the CMS was 89.3 ± 8.8 and the VAS score was 2.1 ± 0.9. The mean ID/CL ratio was 0.19 ± 0.1 and 19 patients (51.4%) were between 0.17 and 0.24. Reduction loss was observed in nine patients (24.3%). There were no significant differences between Group 1 and Group 2 regarding operation time (p = 0.998), ID/CL ratio (p = 0.442), reduction loss (p = 0.458), CMS (p = 0.325), and VAS score (p = 0.699). Of the 28 patients without reduction loss, 16 had an ID/CL ratio between 0.17 and 0.24 (p = 0.43). Furthermore, within the 0.17–0.24 interval, CMS was higher with an average of 91.8 ± 5.1 compared to the other intervals (p = 0.559).ConclusionThe clinical and functional outcomes of acute type 3 and type 5 ACJ dislocation operated open and arthroscopically with single‐bundle SLD are similar and satisfactory. A clavicular tunnel position in the range of 0.17–0.24 (ID/CL ratio) is recommended to maintain postoperative reduction.
An observational study of gastric contents in pediatric patients with long bone fracture using gastric ultrasound
Authors: Soneru Codruta N. , Reviere Anna N. , Petersen Timothy R. , Paluska Matthew R. , Davis Donnis DeQuan , Falcon Ricardo J. 
Published: May 2024

AbstractBackgroundThe retention of gastric contents at surgery presentation is a risk factor for perioperative aspiration. A preoperative fasting (nil per os; NPO) interval is widely used to reduce this risk, but this approach is based on assumptions about the prevalence of typical gastric emptying rates. We assessed NPO guidelines' reliability with ultrasound (US) imaging and suction in pediatric patients presenting for single long‐bone fracture repair after appropriate NPO intervals, when nearly all should have had empty stomachs.Aims and MethodsThis prospective cross‐sectional observational study comprised 200 pediatric surgical patients. As their NPO times varied by food/drink type, we defined “weighted NPO units” as the lowest multiple of elapsed recommended NPO times between consumption and surgery for each type of food or drink. We used US to image the stomach and its contents before anesthesia induction, followed by gastric suction. We evaluated the relationships between weighted NPO units, US gastric contents grade, opioid analgesic dosage and timing, and suctioned volume.ResultsDespite meeting typical NPO standards (median 14 h fasting), many patients retained nontrivial quantities of gastric contents at surgery. Weighted NPO units did not exhibit statistically‐significant relationships with either suctioned volume or US grade. However, suctioned volume did correspond well to US grade.ConclusionNPO status may be a less reliable predictor of gastric contents at anesthesia induction in this patient population than has been assumed. Bedside US screening appears to provide more useful information for the planning of airway management.
Trust, collaboration, and participation in governance: A Nordic perspective on public administrators' perceptions of citizen involvement
Authors: Vento Isak 
Published: May 2024

AbstractThis study analyzes public administrators' trust in citizens' capacities to participate in governance, their collaborative tendency, and the association between these factors and public administrators' willingness to implement citizen involvement efforts. The purpose of the study is to examine whether public administrators' trust in citizens' participatory capacities predicts a willingness to implement citizen participation efforts within the central administration of a Nordic welfare country. The central administration of Finland presents a counter case to previous studies, which have mostly focused on the United States. A unique survey of administrators, operationalized similarly to previous studies, was conducted, and analysis of the data provides both confirmatory and novel insights. The analysis finds that administrators' trust in citizens' participatory capacities strongly predicts their willingness to implement citizen participation initiatives. However, this relation can significantly decrease or increase depending on the degree to which administrators value the procedural legitimacy of collaborative governance.
Soil tillage reduction as a climate change mitigation strategy in Mediterranean cereal‐based cropping systems
Authors: Fiorentini Marco , Orsini Roberto , Zenobi Stefano , Francioni Matteo , Rivosecchi Chiara , Bianchini Marco , di Tella Biagio , D'Ottavio Paride , Ledda Luigi , Santilocchi Rodolfo , Deligios Paola 
Published: May 2024

AbstractAccording to climate change projections, global temperatures would increase by 2°C by 2070, and agriculture is expected to be among the most affected sectors, particularly intensive field crops like cereals. Therefore, researchers need to investigate the most cost‐effective agricultural strategies that can prevent production losses and ensure global food security. This study aimed to identify the limiting factors of durum wheat (Triticum turgidum L. subsp. Durum (Desf.) Husn.) yield production under Mediterranean conditions. Durum wheat yield data of over 5 years (2017–2022), from a 30‐year rainfed long‐term experiment conducted in the ‘Pasquale Rosati’ experimental farm of the Polytechnic University of Marche in Agugliano, Italy (43°32’ N, 13°22′ E, 100 a.s.l.) on Calcaric Gleyic Cambisols with a silt‐clay texture, were analysed and compared with the recorded thermo‐pluviometric trend. The field trial included two soil managements (no tillage vs. conventional tillage) and three Nitrogen (N) fertilization levels (0, 90, and 180 kg N ha−1). The most important driver for durum wheat production was N fertilization. However, in the absence of N fertilization, no tillage showed a higher yield (+1.2 t ha−1) than conventional tillage due to the accumulation of organic matter in the soil. When wheat was fertilized with 90 kg N ha−1, no tillage resulted in 25% yield more than conventional tillage (+1.2 t ha−1), but this occurred only when the increase in temperatures was constant from January until harvest (this happened in 3 of 5 years of monitoring). The non‐constant increase in temperature from January to wheat harvest may hamper crop phenological development and reduce the potential yield. The highest fertilization rate (180 Kg N ha−1) resulted in the highest wheat yields regardless of soil management and thermo‐pluviometric trends (5.78 t ha−1). After N fertilization and soil management, the minimum and maximum temperature in February and the maximum temperature in April were crucial for durum wheat production under Mediterranean condition. When there is non‐constant increase in temperature from January to wheat harvest no‐tillage should be preferred over conventional tillage because wheat yields did not reduce under no tillage. Thus, agricultural policies that support the switch from conventional tillage to no‐tillage management should be promoted to enable food security in Mediterranean environments.
How do transfusion services manage patients taking therapies such as anti‐CD38 and anti‐CD47 known to interfere with red blood cell compatibility testing?
Authors: Murphy Michael F. , Rajbhandary Srijana , Carayiannis Sharon , Cohn Claudia S. 
Published: May 2024

AbstractBackgroundDrugs such as daratumumab (Darzalex, anti‐CD38) and Hu5F9‐G4 (magrolimab, anti‐CD47) may interfere with red blood cell compatibility testing as CD38 and CD47 are expressed on red blood cells.Study Design and MethodsA survey of AABB member transfusion services was undertaken to understand their experiences of managing patients taking therapeutic monoclonal antibodies that are known to interfere with blood grouping and compatibility testing.ResultsThe survey was distributed to the contact person at US‐based AABB member transfusion services. The response rate was 27%. 172 of 240 (72%) indicated they had difficulties in performing compatibility testing in patients taking daratumumab and 66 of 91 (73%) reported difficulties in performing compatibility testing in patients taking magrolimab. Actions taken to provide compatible blood for these patients included referral of all samples to a reference center, blood group pheno/genotyping the patient in advance of starting the drug, treating reagent cells with 0.2 M dithiothreitol and using K‐negative red cell units for patients taking daratumumab, and Gamma‐clone (Immucor) anti‐IgG for indirect antiglobulin testing for patients taking magrolimab. Lack of communication from clinical services about drug treatment was identified as a concern.ConclusionThe results of the survey demonstrate that transfusion services are having challenges with the transfusion management of patients taking therapeutic monoclonal antibodies, and further education is needed.
Mechanical Deformation in Lithium-Ion Battery Electrodes: Modeling and Experiment
Authors: Foster J. M. , Hahn Y. , Patanwala H. , Oancea V. , Sahraei E. 
Published: May 2024

Abstract
Models that can accurately describe deformation and stress in lithium-ion batteries are required to inform new device designs that can better withstand mechanical fatigue. Developing such models is particularly challenging because (i) there is a need to capture several different materials including active materials, binders, current collectors, and separators, and (ii) the length scales of interest are highly disparate (ranging from a few microns, relevant to active material particles, up to centimeters, relevant to whole devices). In this study, we present a continuum mechanical model that resolves individual active material particles of a nickel-manganese-cobalt-oxide cathode, and predicts the mechanical response of the cathode coating as a whole. The model is validated by comparison with experimental tests which mimic industrial-scale electrode calendaring, and then a parametric study is conducted to provide insight into the roles of the material and geometric properties of the electrode's constituents on the cathode's overall behavior.
A Feature Extraction Method for Prognostic Health Assessment of Gas Compressor Valves
Authors: Chesnes Jacob J. , Nelson Daniel A. , Kolodziej Jason R. 
Published: May 2024

Abstract
This article presents features derived from the pressure–volume (PV) diagram that is useful in estimating different valve faults in reciprocating compressors with a strong potential of remaining useful life prediction. The PV diagram is expected to deviate depending on valve wear conditions. Common valve degradation scenarios are explored in this work (leakage, seat wear, and spring fatigue) and are located in the suction and discharge assemblies of a Dresser-Rand ESH-1 compressor commonly used in the petrochemical industry. The proposed method estimates well-understood physical phenomena, the polytropic exponent on the compression, and expansion phase as well as the discharge and suction valve loss power and uses them as features for a quadratic discriminant analysis. The features are created through in-cylinder pressure, suction pressure, discharge pressure, and crank angle measurements collected on a single-stage, dual-acting compressor operating on air with wear precisely machined and seeded into the poppets of the inlet and outlet valves. A very high classification accuracy is achieved in distinguishing the wear types, severity, and location with strong prognostic trends.
A Hybrid Actuator Model for Efficient Guided Wave-Based Structural Health Monitoring Simulations
Authors: Sharma Sanjay , Mesnil Olivier , Recoquillay Arnaud , Chapuis Bastien 
Published: May 2024

Abstract
Simulation has been recognized as a promising option to reduce the time and costs associated with determining probability of detection curves to demonstrate the performance of guided wave-based structural health monitoring (GW-SHM) systems. Time-domain transient spectral finite element schemes have been used for large GW-SHM simulation campaigns, but the most common piezoelectric transducer model used for actuation, the pin force model, has limitations in terms of its range of validity. This is because the excitation frequency for the pin force model has only been validated far below the first electromechanical resonance frequency of the piezoelectric transducer mainly due to not considering the normal stress and dynamics of the transducer. As a result, the value of simulation tools for performance demonstrations may be limited. To address this limitation, this paper introduces a hybrid actuator model that integrates frequency-dependent complex interfacial stresses in both the shear and normal directions, computed using finite elements. These surface stresses are compatible with time-domain transient spectral finite element schemes, enabling their seamless integration without compromising the required performance for conducting intensive simulation campaigns. The proposed hybrid actuator model undergoes validation through a combination of simulation and experimental studies. Additionally, a comprehensive parametric study is conducted to assess the model’s validity across a wide range of excitation frequencies. The results demonstrate the accurate representation of the transduction signal above the piezoelectric transducer’s first free electromechanical resonance frequency.
Effect of Cavity Shapes on the Lubrication Performance of High Precision Static and Dynamic Thrust Bearing Under Eccentric Load
Authors: Yu Xiaodong , Lin Yanlong , Wang Peng , Lan Zhiyuan , Shao Mingjuan , Li Lu , Li Enzhao , Yang Xinyi , Dai Ruichun , Jia Wentao , Wang Junfeng , Jiao Jianhua , Jiang Hui 
Published: May 2024

Abstract
The oil cavity shapes, which represent the spatial structures for storing lubricant in static and dynamic thrust bearings, and offset distances, defined as the horizontal distances between the load center and the bearing rotational axis under eccentric loads, directly impact the flow mode of lubricant, pressure, and temperature distribution during bearing operation, so these are the key factors that influence the lubrication performance and the accuracy of bearings. The equations for flow and load-carrying capacity of the sector, runway, and double rectangular cavities are derived, and mathematical models are established for different cavities at various tilt positions. Then pressure and temperature fields at different offset distances are analyzed. As the offset distances increase, there is a corresponding increase in the maximum pressures within the sector, runway, and double rectangular cavities by 90.5 kPa, 93.3 kPa, and 30.9 kPa, but average pressures show only minor fluctuations. Concurrently, the maximum temperatures within these cavity shapes are observed to increase by 0.5 K, 0.6 K, and 0.8 K, respectively. The results show that appropriate offset distance can improve the lubrication performance. The runway cavity has the highest load-carrying capacity among the three cavity shapes, while the sector cavity experiences the slightest temperature increase. As the temperature increase in all three cavity shapes is small, the runway cavity exhibits superior performance. The error between simulation and experimental results is less than 10%, which verifies the correctness of the simulation method.
Monitoring Within-Individual Dose–Response Relationships in Professional Soccer Players: The Importance of Fitness Level
Authors: Rabbani Alireza , Ermidis Giorgios , Clemente Filipe Manuel , Anderson Liam 
Published: May 2024

Purpose: To (1) examine within-individual player dose–response associations between selected training-load measures and changes in aerobic fitness level via submaximal exercise heart rate (HRex%) and (2) measure the relationships between these dose–response associations with basal HRex% (to study the influence of fitness level on dose–response relationship). Methods: During an in-season phase, selected training-load measures including total minutes, total distance, mechanical work (the sum number of accelerations and decelerations > 3 m2), high metabolic load distance, and Edwards’ training impulse were collected via Global Positioning System and heart-rate sensors for analyzing accumulated load. A submaximal warm-up test was used repeatedly before and after 9 phases to elicit HRex% and track fitness changes at an individual level. Results: Negative to positive extensive ranges of within-individual associations were found among players for different metrics (r = −.84 to .89). The relationship between pooled HRex% (basal fitness) and dose–response correlations showed inverse very large (r = −.71) and large (r = −.65) values for accumulated weekly minutes and distance. However, moderate values were found for all other measures (r = −.35 to −.42). Conclusions: Individual players show extensive different ranges of dose–response associations with training measures. The dose–response association is influenced by players’ fitness level, and players with lower fitness levels show stronger inverse relationships with accumulated minutes and total distance.