bluuebunny/crossref_metadata_2025_split huggingface dataset:
Notch Signaling Is Necessary to Maintain Quiescence in Adult Muscle Stem Cells
Authors: Bjornson Christopher R.R. , Cheung Tom H. , Liu Ling , Tripathi Pinky V. , Steeper Katherine M. , Rando Thomas A. 
Published: November 2011

Abstract
Satellite cells (SCs) are myogenic stem cells found in skeletal muscle that function to repair tissue damaged by injury or disease. SCs are quiescent at rest, although the signaling pathways required to maintain quiescence are unknown. Using a transgenic Notch reporter mouse and quantitative reverse-transcription polymerase chain reaction analysis of Notch target genes, we determined that Notch signaling is active in quiescent SCs. SC-specific deletion of recombining binding protein-Jκ (RBP-Jκ), a nuclear factor required for Notch signaling, resulted in the depletion of the SC pool and muscles that lacked any ability to regenerate in response to injury. SC depletion was not due to apoptosis. Rather, RBP-Jκ-deficient SCs spontaneously activate, fail to self-renew, and undergo terminal differentiation. Intriguingly, most of the cells differentiate without first dividing. They then fuse with adjacent myofibers, leading to the gradual disappearance of SCs from the muscle. These results demonstrate the requirement of Notch signaling for the maintenance of the quiescent state and for muscle stem cell homeostasis by the regulation of self-renewal and differentiation, processes that are all critical for normal postnatal myogenesis.
Disclosure of potential conflicts of interest is found at the end of this article.
Long‐term progression of Alzheimer's disease in patients under antidementia drugs
Authors: Gillette‐Guyonnet Sophie , Andrieu Sandrine , Nourhashemi Fati , Gardette Virginie , Coley Nicola , Cantet Christelle , Gauthier Serge , Ousset Pierre‐Jean , Vellas Bruno ,   REAL.FR study group
Published: November 2011

AbstractBackgroundPatients with Alzheimer's disease (AD), even in the presence of symptomatic relief from medical intervention, face a persistent worsening of cognitive decline and performance in activities of daily living. Data regarding the long‐term disease progression outside of therapeutic trials are lacking. We examined the effects of standard of care for AD patients on the prognosis of the disease in a real‐life study over a 4‐year period.MethodsA total of 686 patients with mild‐moderate AD were enrolled in 16 memory clinics (REseau sur la maladie d’ Alzheimer FRançais [REAL.FR] cohort) and followed up twice annually with tools used in therapeutic trials (Mini‐Mental Status Examination, Alzheimer Disease Assessment Scale‐cognitive subscale [ADAS‐cog]: cognitive function, Clinical Dementia Rating: dementia severity, Activity of Daily Living [ADL]: incapacities, NeuroPsychiatric Inventory: neuropsychiatric symptom).ResultsMore than 90% of the patients used AD‐specific medication over 4 years. Patients lost on average 2.4 points per year on the Mini‐Mental Status Examination and gained 4.5 points on the ADAS‐cog. ADL and NeuroPsychiatric Inventory scores became significantly worse over time. Incidence of incapacities for ADL and worsening of neuropsychiatric symptoms were 52.5 (95% confidence interval [CI]: 47.7–57.4) and 51.1 (95% CI: 46.2–56.1), respectively. Rates of mortality and institutionalization were 7.4 (95% CI: 6.2–8.5) and 13.4 (95% CI: 11.7–15.1). In all, 17% of patients in mild stage at baseline (Clinical Dementia Rating = 0.5) did not experience a major event (functional disabilities, neuropsychiatric symptoms, or death) over a 4‐year period.ConclusionsAs compared with previous surveys, the current study shows slower rates of decline in AD patients. The present data also underline the high level of variability of disease progression among AD patients. Outcome measures commonly used in clinical trials will need to take into account the recent changes in the prognosis of the disease.
Evidence of crystallization in residual, Cl–F-rich, agpaitic, trachyphonolitic magmas and primitive Mg-rich basalt–trachyphonolite interaction in the lava domes of the Phlegrean Fields (Italy)
Authors: MELLUSO LEONE , DE' GENNARO ROBERTO , FEDELE LORENZO , FRANCIOSI LUIGI , MORRA VINCENZO 
Published: November 2011

AbstractThe lava domes in the northwestern (Cuma), northern (Punta Marmolite) and central (Accademia) parts of the Phlegrean Fields are the subject of this study. The Cuma and Punta Marmolite trachyphonolitic lava domes are among the oldest Phlegrean products cropping out. The Cuma rocks have an agpaitic groundmass, with early alkali feldspar, Fe-rich clinopyroxene, Fe-edenite and sodalite and late rosenbuschite, fluorite, baddeleyite, pyrochlore, britholite, monazite, aegirine (often Zr-rich) and exceptionally Fe–Mn-rich olivine. The bulk-rock compositions at Cuma have some of the highest concentrations of Zn, Mn, Zr, Nb, Th, U and lanthanides among the Phlegrean Fields rocks, and some of the lowest MgO, P2O5, Sr, Eu and Ba. The Punta Marmolite dome is chemically less evolved, and lacks characteristic agpaitic minerals, but features alkali feldspar, sodalite, nepheline and relatively Na-poor, Fe-rich hedenbergite, with rare Ca-rich plagioclase xenocryst cores. The Accademia dome, belonging to the recent activity, is latitic to trachytic in composition, has highly forsteritic olivine (with chromiferous spinel inclusions), calcic plagioclase and Mg-rich diopside (± phlogopite) xenocrysts in an evolved host rock (with phenocrysts and microlites of alkali feldspar, Fe-rich clinopyroxene, Fe-rich amphibole, magnetite, Fe-rich olivine and accessory baddeleyite, zirconolite and fluorite). There is clear evidence of open-system magma crystallization in the form of interaction between a crystallizing, primitive shoshonitic basalt in a reservoir already filled by rather evolved trachytic magma. The magmatic evolution towards the evolved compositions is dominated by crystallization of more and more Na-rich alkali feldspar in a Cl-, F-rich and relatively H2O-poor environment. Input of mafic magma is evident in many trachytic eruptions of the Phlegrean Fields and even in the products of the Campanian Ignimbrite, but eruptions having mineral assemblages rich in xenocryst phases as well as eruptions virtually free of mafic magma input are also frequently observed throughout the history. This suggests a variable pattern of open- and closed-system crystallization, which may or may not be linked to explosive activity, and that can be caused by intermittent supply of basaltic magma from depth.
Absence ofHelicobacter pyloriin healthy laryngeal mucosa
Authors: Pajić-Penavić I , Đanić D , Maslovara S , Gall-Trošelj K 
Published: November 2011

AbstractObjectives:To evaluate the presence ofHelicobacter pyloriin healthy laryngeal mucosa.Design:Prospective analysis ofHelicobacter pyloricolonisation in healthy laryngeal mucosa, using the13C urea breath test and polymerase chain reaction analysis.Subjects:Twenty randomly chosen men (28–78 years) without laryngeal pathology or gastrointestinal disease were investigated. All subjects were scheduled for elective operative procedures, under general, endotracheal anaesthesia. Cytobrush samples were taken forHelicobacter pyloriDNA detection. Nested polymerase chain reaction testing was performed on DNA solutions using two primer pairs from the urease A gene of theHelicobacter pylorigenome. The13C urea breath test was performed on two exhalation samples.Results:Eight (40 per cent) of the subjects were positive for urease on urea breath testing; none were positive forHelicobacter pyloriDNA on polymerase chain reaction testing.Conclusion:Based on these results, we do not considerHelicobacter pylorito be a normal constituent of healthy laryngeal microflora.
Simultaneous occurrence of a thyroglossal duct cyst and a lingual thyroid in the absence of an orthotopic thyroid gland
Authors: Madana J , Kalaiarasi R , Yolmo D , Gopalakrishnan S 
Published: November 2011

AbstractObjective:We report an extremely rare case of the simultaneous occurrence of a thyroglossal duct cyst and a lingual thyroid in the absence of an orthotopic thyroid gland, in a seven-year-old girl from South India.Method:Case report and a review of the English language literature on the subject.Results:The patient presented with a mass on the tongue that had been present for three years, and an anterior neck swelling that had been present for two years. Examination revealed a midline, pinkish, firm mass present on the posterior one-third of the tongue. The neck showed a midline cystic swelling in the infrahyoid position. Radiological imaging confirmed the clinical findings, revealing the absence of her thyroid gland in the normal location. Sistrunk's procedure was performed leaving behind a lingual thyroid. At 13-month follow up, the patient was euthyroid with no recurrence.Conclusion:To our knowledge the association of a lingual thyroid and a thyroglossal cyst has only been reported once in the literature. The presence of a lingual thyroid in the absence of a normally located thyroid gland or functioning thyroid tissue along the thyroglossal tract, confirmed by radionuclide and computed tomography imaging, may indicate the failure of the normal descent of the thyroid gland during embryonic development. This probable absence of the descent of the thyroid raises questions regarding the origin of thyroglossal duct cysts.
Remote sensing analysis reveals habitat, dispersal corridors and expanded distribution for the Critically Endangered Cross River gorillaGorilla gorilla diehli
Authors: Bergl Richard A. , Warren Ymke , Nicholas Aaron , Dunn Andrew , Imong Inaoyom , Sunderland-Groves Jacqueline L. , Oates John F. 
Published: November 2011

AbstractHabitat loss and fragmentation are among the major threats to wildlife populations in tropical forests. Loss of habitat reduces the carrying capacity of the landscape and fragmentation disrupts biological processes and exposes wildlife populations to the effects of small population size, such as reduction of genetic diversity and increased impact of demographic stochasticity. The Critically Endangered Cross River gorillaGorilla gorilla diehliis threatened in particular by habitat disturbance because its population is small and it lives in an area where high human population density results in intense exploitation of natural resources. We used remotely-sensed data to assess the extent and distribution of gorilla habitat in the Cross River region and delineated potential dispersal corridors. Our analysis revealed > 8,000 km2of tropical forest in the study region, 2,500 km2of which is in or adjacent to areas occupied by gorillas. We surveyed 12 areas of forest identified as potential gorilla habitat, 10 of which yielded new records of gorillas. The new records expand the known range of the Cross River gorilla by > 50%, and support genetic analyses that suggest greater connectivity of the population than previously assumed. These findings demonstrate that considerable connected forest habitat remains and that the area could potentially support a much larger gorilla population if anthropogenic pressures such as hunting could be reduced.
Swimming locomotion modeling for biomimetic underwater vehicle with two undulating long-fins
Authors: Shang Liuji , Wang Shuo , Tan Min , Cheng Long 
Published: November 2011

SUMMARYA biomimetic underwater vehicle, which is propelled by two undulating long-fins, is introduced in this paper. The undulating or oscillating movements of symmetrical long-fins cause the complex locomotion of biomimetic underwater vehicle. For convenience, three motion modes are proposed and considered firstly. Then an inertial unit is installed for collection of accelerations and angular velocity. The underwater vehicle's MIMO model is reduced into a SISO model by some simplifications. A sine wave function deduced from the long-fin's time-varying membrane is proposed and used as the input of the biomimetic underwater vehicle ARMA model, and velocity or angular velocity is considered as the model output. The algorithms based on recursive weighted least squares are applied for model parameter identification. Experiments carried out with a long-fin propelled underwater vehicle. The experimental results show that the proposed methods can build valid locomotion models for three motion modes efficiently.
Mafic granulites of the Schirmacher region, East Antarctica: fluid inclusion and geothermobarometric studies focusing on the Proterozoic evolution of the crust
Authors: Rao D. Rameshwar , Sharma Rajesh , Gururajan N. S. 
Published: November 2011

AbstractIn the Proterozoic complex of the Schirmacher region of East Antarctica, a retrograde pressure–temperature (P–T) history has been inferred through quantitative geothermobarometry and fluid inclusion studies of the mafic granulites. Microthermometric investigations of the fluid phases trapped in quartz and garnet identified three types of inclusions, namely, earliest pure CO2 inclusions (0·987–1·057 g cm−3), CO2–H2O inclusions and aqueous inclusions.The temperature and pressure of metamorphism have been estimated through different calibrations of geothermometers and geobarometers. The mineral reactions and compositional zoning in the minerals record P–T conditions from nearly 837 ± 26°C, 7·1±0·2 kbar to 652 ± 33°C, 5·9 ± 0·3 kbar. A good correlation between the fluid and mineral data is observed. The isochores typical of highdensity CO2 fluids fall well within the P–T box estimated by mineral thermobarometry. The abundance of primary CO2 inclusions in early metamorphic minerals (notably quartz and primary garnet) and the general correspondence between fluid and mineral P–T data indicate a ‘fluid-present’ carbonic regime for the high-grade metamorpism; however, from the present data largescale CO2 advection could not be envisaged. The subsequent stages involved a decrease in CO2 density, a progressive influx of hydrous fluids and the generation of retrograde amphibolite facies metamorphism in the area.The estimated P–T conditions of the region suggest that the rocks were metamorphosed at a depth of 19–24 km, with a geothermal gradient of c. 3°5C km−1. The estimated P–T conditions of the rocks imply a clockwise P–T–t path with a gradual decrease in temperature of around 250°C and a decrease in pressure of around 1700 bar. They have a dP/dT gradient of ≈7 ± l bar °C−1, arguing for an isobaric cooling history of the terrane under normal thickened crust after the underplating of mantle-derived material.
The morphology and phylogenetic significance ofKerygmachela kierkegaardiBudd (Buen Formation, Lower Cambrian, N Greenland)
Authors: Budd Graham E. 
Published: November 2011

AbstractSpecimens ofKerygmachela kierkegaardiBudd are described, from the Lower Cambrian Sirius Passet fauna of N Greenland. The cephalic region is characterised by a pair of stout unsegmented appendages each bearing long spinose processes, and an anterior mouth. The trunk shows alternating rows of tubercles and transverse annulations along the axis, to which are attached 11 pairs of gill-bearing lateral lobes and lobopodous limbs. The caudal region is small, and bears two long tail spines. There is some evidence for circular musculature arranged around the trunk and a dorsal, longitudinal sinus, and several details of the muscular pharynx have been preserved.The combination of characters found inKerygmachelaallows it to be allied with the lobopods, represented in the extant fauna by the onychophorans, tardigrades, and possibly the pentastomids, and in the Cambrian fossil record by a morphologically diverse set of taxa, some of which are not assignable to the extant groupings. It also shares important characters with the previously problematic Burgess Shale formsOpabinia regalisWalcott andAnomalocarisWhiteaves, and the Sirius Passet form Pambdelurion Budd. These taxa together form a paraphyletic group at the base of the clade of biramous arthropods. The position of the so-called ‘Uniramia’ remains unclear. It can be demonstrated from the reconstruction of the arthropod stem-group that full arthropod segmentation has a different derivation from that of the annelids. In line with other recent analyses, this suggests that the ‘Articulata’ of Cuvier should be dismantled, and the arthropods considered to be a group of protostomes which are phylogenetically distinct from the classic spiralians. Arthropod affinities may rather lie with the other moulting animals, in the so-called ‘Ecdysozoa’.
The postcranial skeleton ofDiscosauriscusKuhn, a seymouriamorph tetrapod from the Lower Permian of the Boskovice Furrow (Czech Republic)
Authors: Klembara Jozef , Bartík Ivan 
Published: November 2011

AbstractThe description of the postcranial skeleton of larval, metamorphic and early juvenile specimens of the genusDiscosauriscusis based on three-dimensional material and includes a description of the ontogeny of the swollen neural arches and the central elements of the vertebrae.Discosauriscushas 24 (or 23) presacral vertebrae. The morphology of the atlas–axis complex is similar to that inSeymouria sanjuanensis. The neural arches start to swell slightly in specimens of late larval stage; they are completely swollen immediately after metamorphosis. There are about 40 caudal vertebrae and one sacral vertebra. The atlantal pleurocentrum is paired in metamorphic individuals. In postmetamorphic individuals, the pleurocentra 2–5 are not completely closed dorsally; the pleurocentra 6–30 form complete discs. The first haemal arch is situated on the sixth caudal vertebra. The atlantal rib is present. There are six caudal ribs.Discosauriscushas an anocleithrum which is the first record of this dermal pectoral element within seymouriamorphs and Lower Permian tetrapods. The scapula and the coracoid are separate elements. The phalangeal formula of the manus is 2, 3, 4, 5, 3. The iliac blade has a massive, almost horizontally oriented posterior process; the anterior process is absent. The phalangeal formula of the pes is 2, 3, 4, 5, 3. Rounded ventral scales are present. The comparison and evaluation of the available postcranial elements ofDiscosauriscus, Utegenia, AriekanerpetonandSeymouriasupport the view thatDiscosauriscusandAriekanerpeton, forming the family Discosauriscidae, are immediately related genera.
The East Kirkton Limestone, Viséan, of West Lothian, Scotland: introduction and stratigraphy
Authors: Rolfe W. D. I. , Durant G. P. , Baird W. J. , Chaplin C. , Paton R. L. , Reekie R. J. 
Published: November 2011

ABSTRACTA brief history of research into the unusual laminated and spherulitic East Kirkton Limestone (Brigantian, Viséan) is given. It documents the paucity of fossil finds until 1984, when S. P. Wood discovered a previously unsuspected terrestrial biota. Some early finds, such as stromatolites, have since been overlooked, while others were misinterpreted, e.g. a ‘fish-bone’ collected before 1870 proves to be amphibian. A formal lithostratigraphic description is given of the three beds that comprise the c. 15 m sequence in East Kirkton Quarry: the East Kirkton Limestone, overlain by Little Cliff Shale and Geikie Tuff, the latter two being here formally named. Lithological descriptions and a unit-by-unit distribution of major elements of the biota are provided for a measured section comprising 88 units. This is based on bed-by-bed excavations carried out 1985-92, supplemented by nine boreholes. Two 3 m-thick massive limestones lenses are recorded from the quarry and a probable third was proved in a borehole. Brief reports are given on the ‘stromatolites’ (by M. R. Walter), bivalve molluscs (R. M. C. Eagar and R. B. Wilson), ostracods (J. Pollard) and gypsum pseudomorphs.
Palaeoecology of the Viséan of East Kirkton, West Lothian, Scotland
Authors: Clarkson E. N. K. , Milner A. R. , Coates M. I. 
Published: November 2011

ABSTRACTThe Viséan sequence at East Kirkton was deposited in a shallow lake, set within a richly vegetated landscape formed of volcanic cones a few hundred metres high. There was little volcanic activity, however, while the lake existed, and the many tuff horizons within the sequence were washed in during weathering. The lake may have been generally cool, though of unusual water chemistry, as a result of which the spherulitic East Kirkton Limestone precipitated. At times, however, water temperatures may have risen sharply through localised hot-spring activity; both factors deterred ‘normal’ aquatic life.The bulk of the preserved biota consists of plants (permineralisations and compressions) and dominantly land-living animals, including the oldest terrestrial tetrapods (amphibians and reptiliomorphs), large terrestrial-aquatic eurypterids, the first harvestman and rare millipedes. All these animals lived close to the lake, in a fire-prone forest dominated by gymnosperms and pteridosperms.At a late stage in the history of the lake, deposition of spherulitic limestones was replaced by black shales, bearing a ‘standard’ Oil-Shale fish fauna, suggesting that the isolated lake had linked with a larger fish-bearing water body. This is coupled with a shift to a lycopod-dominated flora and may indicate a climatic change to wetter conditions. Finally the lake silted up with tuff, ending an existence of only a few tens of thousands of years.
Fertility of metapelites and metagraywackes during leucogranite generation: an example from the Black Hills, U.S.A.
Authors: Nabelek Peter I. , Bartlett Cindy D. 
Published: November 2011

In order to elucidate how mineralogy and composition of crustal sources influences production of leucogranite magmas, we modelled the potential fertility of a sequence of metapelites and metagraywackes from the Black Hills, South Dakota, U.S.A., using a least-squares mixing approach. Rocks analogous to the Black Hills schists were the sources of the Harney Peak leucogranite. Both muscovite and biotite fluid-absent melting reactions (MM and BM, respectively) were investigated. Using the Harney Peak Granite composition as the melt analogue and mineral compositions from the schists for mixing calculations, it is shown that MM of metapelites would lead to highly variable residue mineralogy in the investigated samples. The average residue includes 36 wt.% biotite, 32 wt.% quartz, 12 wt.% plagioclase, 8 wt.% K-feldspar, 9 wt.% sillimanite and 2 wt.% garnet. Melt production ranges from 5% to 23% with an average of 14%. It is limited by the amount of H2O that must be in the melt at the conditions of melting, relative to the amount that is in muscovite in the source rocks. Plagioclase-rich metagraywackes contain little to no muscovite, thus MM cannot occur in them.Although BM is continuous over a wide temperature range, for the purposes of modelling melting at 975°C and 10kbar was chosen. The temperature is near the terminal stability of biotite, thus the calculations give near-maximum melt production. At this temperature, the mineralogy of the model residues from both metapelites and metagraywackes is dominated by garnet. The potential melt production in the metapelites ranges from 0% to 58% with an average of 32%. It is limited by the availability of plagioclase in the source rocks. Potential melt production in the metagraywackes ranges from 9% to 37% with an average of 23%. At the chosen conditions of melting, melt production is limited by the available K in biotite, although at lower temperatures, the available H2O limits melt production. The total potential melt production (MM + BM) in the metapelites is higher because they have on average a low normative An/Ab ratio (0·14) that approaches the ratio in the leucogranites (0·04). The paragonite component in muscovite significantly contributes to the low ratio in the metapelites. The higher ration (0·27) in the metagraywackes is denned by the feldspar composition.Using the calculated melt fractions and residue mineralogies, we modelled the concentrations of Rb, Sr and Ba in the melts, as these elements are important indicators of melt-generating processes. The results indicate that both Sr and Ba are likely to be heterogeneous in extracted melt batches and will be depleted in partial melts relative to their pelitic sources, irrespective of whether the melting is fluid-absent or fluid-present.