bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Ni‐Catalyzed Reductive Allylation of Unactivated Alkyl Halides with Allylic Carbonates.
Authors: Dai Yijing , Wu Fan , Zang Zhenhua , You Hengzhi , Gong Hegui 
Published: May 2012

AbstractA wide variety of primary and secondary unactivated alkyl halides is smoothly allylated with allylic carbonates in the presence of Ni—N,N,N‐tridentate pyridine complexes to generate E‐alkenyl products, exclusively.
ChemInform Abstract: Efficient and Divergent Synthesis of Functionalized Cyclopropanes via Iodoform Reaction.
Authors: Zhang Dingyuan , Zhang Rui , Xiang Dexuan , Zhang Ning , Liang Yongjiu , Dong Dewen 
Published: May 2012

AbstractA direct one‐pot conversion of acetylcyclopropanes into cyclopropylamides is achieved by iodoform oxidation in the presence of ammonia.
ChemInform Abstract: Rh(I)‐Catalyzed Cyclocarbonylation of Enynes with Glyceraldehyde: An Available Carbonyl Source Derived from Sugar Alcohols.
Authors: Ikeda Keiichi , Morimoto Tsumoru , Tsumagari Takayuki , Tanimoto Hiroki , Nishiyama Yasuhiro , Kakiuchi Kiyomi 
Published: May 2012

AbstractOptically active glyceraldehyde acetonide (II) is employed for the Rh‐catalyzed cyclocarbonylation of various enynes to produce bicyclic cyclopentenone derivatives.
ChemInform Abstract: Microwave‐Promoted One‐Pot Preparation of Fluorinated Propargylamines and Their Chemical Transformation.
Authors: Chen Xiao‐Lei , Zhang Jian‐Min , Shang Wen‐Li , Lu Bei‐Qiong , Jin Jian‐An 
Published: May 2012

AbstractVarious propargylamines of type (X) or (XI) are prepared by a three‐component reaction under conditions C).
ChemInform Abstract: Stereoselective Synthesis of vic‐Halohydrins via L‐tert‐Leucine‐Catalyzed syn‐Selective Aldol Reaction.
Authors: Umehara Atsushi , Kanemitsu Takuya , Nagata Kazuhiro , Itoh Takashi 
Published: May 2012

AbstractA convenient protocol is developed for the highly regio‐ and stereoselective aldol reaction of chloroacetone with aldehydes.
ChemInform Abstract: Lithium Amidoborane, a Highly Chemoselective Reagent for the Reduction of α,β‐Unsaturated Ketones to Allylic Alcohols.
Authors: Xu Weiliang , Zhou Yonggui , Wang Ruimin , Wu Guotao , Chen Ping 
Published: May 2012

AbstractHighly chemoselective reduction of carbonyl group in the presence of C—C double bond is readily achieved by lithium amidoborane under mild reaction conditions.
ChemInform Abstract: Facile Synthesis of α‐Monofluoromethyl Alcohols: Nucleophilic Monofluoromethylation of Aldehydes Using TMSCF(SO2Ph)2.
Authors: Prakash G. K. Surya , Shao Nan , Zhang Zhe , Ni Chuanfa , Wang Fang , Haiges Ralf , Olah George A. 
Published: May 2012

Abstractα‐Trimethylsilyl‐α‐fluorobis(phenylsulfonyl)methane (II) is found to be a novel, viable nucleophilic monofluoromethylating reagent for aldehydes.
ChemInform Abstract: Henry Reaction of Fluorinated Nitro Compounds.
Authors: Hu Huawei , Huang Yangen , Guo Yong 
Published: May 2012

AbstractNitroaldol reaction of fluorinated nitro compounds with various aldehydes results in the diastereoselective formation of anti‐β‐fluoro‐β‐nitroalcohols, in general.
ChemInform Abstract: Palladium‐Mediated Highly Regio‐ and Stereoselective Intermolecular β‐Arylation on Allylic Alcohols: Synthesis of Functionalized Allylic Alcohols.
Authors: Krishna J. , Reddy A. Gopi Krishna , Ramulu B. Venkat , Mahendar L. , Satyanarayana G. 
Published: May 2012

Abstractβ‐Arylation of aromatic allylic alcohols with iodides (II) proceeds under both conventional heating or microwave irradiation to give unexpectedly β‐allylic alcohols as major or sole products.
ChemInform Abstract: Iron‐Catalyzed [3 + 2] Annulation of Aminocyclopropanes with Aldehydes: Stereoselective Synthesis of Aminotetrahydrofurans.
Authors: Benfatti Fides , de Nanteuil Florian , Waser Jerome 
Published: May 2012

AbstractThe reaction tolerates aromatic, aliphatic and alkenic aldehydes.
ChemInform Abstract: An Unique Approach to Catalyst‐Free, One‐Pot Synthesis of Spirooxindole‐Pyrazolines.
Authors: Alizadeh Abdolali , Zohreh Nasrin 
Published: May 2012

AbstractA novel synthesis of title compounds (III) is achieved via in situ generation of 1,1‐bishydrazino‐2‐nitroethylene and subsequent trapping by 2 equiv.
ChemInform Abstract: Synthesis of Oxindoles via Visible Light Photoredox Catalysis.
Authors: Ju Xuhui , Liang Yan , Jia Pingjing , Li Weifei , Yu Wei 
Published: May 2012

AbstractThe cyclization of α‐bromoanilides bearing an electron‐withdrawing group in α‐position towards oxindoles (II), (IV), (VI)/(VII) and (IX) is efficiently achieved under visible light irradiation in the presence of photoredox catalyst Ir(ppy)3.
ChemInform Abstract: 3‐Alkenyl‐2‐silyloxyindoles: An Enabling, Yet Understated Progeny of Vinylogous Carbon Nucleophiles.
Authors: Rassu Gloria , Zambrano Vincenzo , Tanca Rossella , Sartori Andrea , Battistini Lucia , Zanardi Franca , Curti Claudio , Casiraghi Giovanni 
Published: May 2012

AbstractThe title alkenyl(siloxy)indoles (III) serve as suitable substrates in the vinylogous Mukaiyama aldol reaction with aromatic aldehydes to furnish hydroxylated alkylideneoxindoles (V) in good yields with virtually complete γ‐site selectivity and high Z‐selectivity.
ChemInform Abstract: Synthesis of New Donor—Acceptor—Donor Materials via Au‐Catalyzed Double Cascade Cyclization.
Authors: Ferrara Giovanni , Jin Tienan , Oniwa Kazuaki , Zhao Jian , Asiri Abdullah M. , Yamamoto Yoshinori 
Published: May 2012

AbstractDouble cascade cyclization of arenyl tetraynes gives benzothiadiazole derivatives and related compounds.
ChemInform Abstract: Un‐Catalyzed Tandem Knoevenagel—Michael Reaction for the Synthesis of 4,4′‐(Arylmethylene)bis(1H‐pyrazol‐5‐ols) in Aqueous Medium.
Authors: Tale Nilesh P. , Tiwari Girdharilal B. , Karade Nandkishor N. 
Published: May 2012

AbstractThe condensation of aldehydes with two equivalents of pyrazolone (I) in refluxing water gives diarylmethanes (III) in moderate yields without the need for any catalyst.
ChemInform Abstract: Synthesis of Functionalized 2,3‐Dihydroisoxazoles by Domino Reactions in Water and Unexpected Ring‐Opening Reactions of 2,3‐Dihydroisoxazoles.
Authors: Li Ping , Teng Bo‐Tao , Jin Fa‐Gen , Li Xin‐Sheng , Zhu Wei‐Dong , Xie Jian‐Wu 
Published: May 2012

AbstractA convenient synthesis of trisubstituted dihydroisoxazoles (II), (V) and (VIII) is presented, involving the reaction of benzylidenemalononitriles with hydroxylamine in basic medium.
ChemInform Abstract: Synthesis of Thiazolidine‐Fused Heterocycles via exo‐Mode Cyclizations of Vinylogous N‐Acyliminium Ions.
Authors: Stojanovic Milovan , Markovic Rade , Kleinpeter Erich , Baranac‐Stojanovic Marija 
Published: May 2012

AbstractThe 6‐exo cyclization of vinylogous N‐acyliminium ions with tethered O‐, S‐, and N‐nucleophiles proceeds smoothly to afford fused thiazolidines (II) in good yields.
ChemInform Abstract: Rhodium‐Catalyzed Xanthone Formation from 2‐Aryloxybenzaldehydes via Cross‐Dehydrogenative Coupling (CDC).
Authors: Wang Ping , Rao Honghua , Hua Ruimao , Li Chao‐Jun 
Published: May 2012

AbstractWithout any preactivation of the aldehyde function, xanthone scaffolds bearing various functionalities can be generated.
ChemInform Abstract: A Copper(II)‐Catalyzed, Sequential Michael‐Aldol Reaction for the Preparation of 1,2‐Dihydroquinolines.
Authors: Wagner Anna M. , Knezevic Claire E. , Wall Jessica L. , Sun Victoria L. , Buss Joshua A. , Allen LeeAnn T. , Wenzel Anna G. 
Published: May 2012

AbstractMeCN functions as a labile ligand for the copper and as an agent to minimize the hydrolytic catalyst poisoning.
ChemInform Abstract: Synthesis of Aryl‐Substituted 1,4‐Dihydroquinolines by [4 + 2] Cycloaddition of Benzyne with 1‐Azadienes.
Authors: Stokes Sean , Bekkam Markondaiah , Rupp Madeline , Mead Keith T. 
Published: May 2012

AbstractThe N‐tosylated products can be easily transformed into quinolines.
ChemInform Abstract: Synthetic Protocols Mutually Applicable to 4‐Oxoquinolines and 4‐Oxo‐1,8‐naphthyridines: Synthesis of 1‐Aryl‐2‐substituted and 1‐Aryl‐3‐fluoro‐4‐oxo‐quinolines and 4‐Oxo‐1,8‐naphthyridines.
Authors: Awasaguchi Ken‐ichiro , Hayashi Hiromi , Kawai Hyouei , Tominaga Hiroko , Sato Yuichiro , Hayashi Kazuya , Todo Yozo 
Published: May 2012

AbstractVarious 2‐substituted 4‐oxoquinoline and 4‐oxo‐1,8‐naphthyridine derivatives are prepared from the key intermediates (I) and (VIII), respectively.
ChemInform Abstract: Ruthenium‐Catalyzed Oxidative Synthesis of Heterocycles from Alcohols.
Authors: Watson Andrew J. A. , Maxwell Aoife C. , Williams Jonathan M. J. 
Published: May 2012

AbstractCyclization of o‐aminobenzamide (I) with various benzylic and aliphatic alcohols proceeds smoothly under Ru‐catalyzed hydrogen transfer conditions to afford quinazolines (III).
ChemInform Abstract: Copper‐Catalyzed One‐Pot Synthesis of Imidazo/Benzoimidazoquinazolinones by Sequential Ullmann‐Type Coupling and Intramolecular C—H Amidation.
Authors: Xu Hao , Fu Hua 
Published: May 2012

AbstractThe title reaction uses inexpensive CuI—L‐proline as catalyst and oxygen as environmentally friendly and economical oxidant and provides the (benz)imidazoquinazolinone products in good yields.
ChemInform Abstract: Synthesis and in vitro Antiproliferative Evaluation of Pyrimido[5,4‐c]quinoline‐4‐(3H)‐one Derivatives.
Authors: Ai Yong , Liang Yong‐Ju , Liu Jian‐Chao , He Hong‐Wu , Chen Yu , Tang Chu , Yang Guang‐Zhong , Fu Li‐Wu 
Published: May 2012

AbstractNovel pyrimidoquinolone derivatives (VI),(XI),(XII), and (XIII), substituted at positions 2 and 3, are synthesized by using three synthetic routes and evaluated for their antiproliferative activities against a panel of six human cancer cell lines.
ChemInform Abstract: Synthesis of (L)‐4‐Fluorotryptophan.
Authors: Konas David W. , Seci Drilona , Tamimi Safa 
Published: May 2012

AbstractKey step in the synthesis of (L)‐4‐fluorotryptophan (V) is a diastereoselective alkylation of the Schollkopf chiral auxiliary (III) with a fluorinated electrophile.
ChemInform Abstract: New Approach to Flavonols via Base‐Mediated Cyclization: Total Synthesis of 3,5,6,7‐Tetramethoxyflavone
Authors: Kraus George A. , Gupta Vinayak , Kempema Aaron 
Published: May 2012

AbstractThe novel four‐step synthesis of flavones (VI) involves a LDA‐mediated cyclization/isomerization/elimination sequence as the key step.
ChemInform Abstract: Heronamycin A: A New Benzothiazine Ansamycin from an Australian Marine‐Derived Streptomyces sp.
Authors: Raju Ritesh , Piggott Andrew M. , Khalil Zeinab , Bernhardt Paul V. , Capon Robert J. 
Published: May 2012

AbstractInvestigations for cytotoxicity and antimicrobial activity reveal only modest effects against Bacillus subtilis strains.
ChemInform Abstract: Identification and Development of 2,5‐Disubstituted Oxadiazole as Potential Candidate for Treatment of XDR and MDR Tuberculosis.
Authors: Bakal Ravi L. , Gattani Surendra G. 
Published: May 2012

AbstractWith a view to synthesizing a better agent for todays XDR and MDR tuberculosis, a series of tractable small molecules having an oxadiazole core is obtained in four steps from appropriately substituted ethyl esters.
ChemInform Abstract: Optical Sensing of Small Ions with Colloidal Nanoparticles.
Authors: Jimenez de Aberasturi Dorleta , Montenegro Jose‐Maria , Ruiz de Larramendi Idoia , Rojo Teofilo , Klar Thomas A. , Alvarez‐Puebla Ramon , Liz‐Marzan Luis M. , Parak Wolfgang J. 
Published: May 2012

AbstractReview: [emphasis on gold nanoparticles; 112 refs.]
The Preparation of Titanium Dioxide Gas Sensors by the Electric Field Assisted Aerosol CVD Reaction of Titanium Isopropoxide in Toluene
Authors: Panjawi Naitik , Naik Anupriya , Warwick Michael E. A. , Hyett Geoffrey , Binions Russell 
Published: May 2012

AbstractThin films of titanium dioxide are deposited on gas‐sensor substrates at 450 °C from the aerosol‐assisted (AA)CVD of titanium isopropoxide solutions in toluene under the influence of electric fields. Electric fields are generated by applying a potential difference between the inter‐digitated electrodes of the gas‐sensor substrate during the deposition. The deposited films are analyzed and characterized using scanning electron microscopy (SEM), X‐ray diffraction (XRD), and Raman spectroscopy (RS). It is found that an increase in electric field strength during deposition causes changes in the film microstructure, preferential orientation, and growth rate. The gas‐sensor properties of the films are also examined. It is found that applying an electric field during the deposition improves the film microstructure and leads to a two‐fold enhancement in the sensing properties of the film.
CVD Production of Doped Titanium Dioxide Thin Films
Authors: Dunnill Charles W. , Kafizas Andreas , Parkin Ivan P. 
Published: May 2012

AbstractThis review focuses on the formation of doped titanium dioxide films by CVD. It describes a number of the functional applications of titanium dioxide films, and illustrates how these properties can be improved or modified by the introduction of anion and cation dopants. It details some of the underlying theory and looks at how density of states diagrams can be used to explain the doped film properties.
A platinum‐based covalent viability reagent for single‐cell mass cytometry
Authors: Fienberg Harris G. , Simonds Erin F. , Fantl Wendy J. , Nolan Garry P. , Bodenmiller Bernd 
Published: May 2012

AbstractIn fluorescence‐based flow cytometry, cellular viability is determined with membrane‐impermeable fluorescent reagents that specifically enter and label plasma membrane‐compromised nonviable cells. A recent technological advance in flow cytometry uses antibodies conjugated to elemental metal isotopes, rather than to fluorophores, to allow signal detection by atomic mass spectrometry. Unhampered by the limitations of overlapping emission fluorescence, mass cytometry increases the number of parameters that can be measured in single cells. However, mass cytometry is unable to take advantage of current fluorescent viability dyes. An alternative methodology was therefore developed here in which the platinum‐containing chemotherapy drug cisplatin was used to resolve live and dead cells by mass cytometry. In a 1‐min incubation step, cisplatin preferentially labeled nonviable cells from both adherent and suspension cultures, resulting in a platinum signal quantifiable by mass cytometry. This protocol was compatible with established sample processing steps for intracellular cytometry. Furthermore, the live/dead ratios were comparable between mass‐ and fluorescence‐based cytometry. Importantly, although cisplatin is a known DNA‐damaging agent, a 1‐min “pulse” of cisplatin did not induce observable DNA damage or apoptotic responses even within 6‐h post‐exposure. Cisplatin can therefore be used as a viability reagent for a wide range of mass cytometry protocols. © 2012 International Society for Advancement of Cytometry
The analysis of antipsychotic drugs in human matrices using LC‐MS(/MS)
Authors: Saar Eva , Beyer Jochen , Gerostamoulos Dimitri , Drummer Olaf H. 
Published: May 2012

Antipsychotic drugs (APs) are prescribed for a wide range of psychotic illnesses. With more than 35 APs currently available worldwide, this drug class has rapidly gained importance in both clinical and forensic settings. On account of their chemical properties, many APs are present in human specimens at very low concentrations, which complicate their detection using standard gas chromatography–mass spectrometry (GC‐MS) procedures that often cannot provide the required sensitivity. Recent advances in liquid chromatography‐(tandem) mass spectrometry LC‐MS(/MS) technology have enabled accurate detection and quantification of these compounds in various human specimens, indicated by the increasing number of published methods. Method validation has been a particular focus of analytical chemistry in recent times. Recommendations set by several guidance documents are now widely accepted by the toxicology community, as reflected by the guidelines drafted by leading toxicological societies. This review provides a critical review of single‐stage and tandem LC‐MS procedures for the detection and quantification of APs, with a particular emphasis on appropriate method validation.The quality of published methods is inconsistent throughout the literature. While the majority of authors incorporate some validation experiments in their respective method development, a large number of published methods lack essential components of method validation, which are considered mandatory according to the guidelines.If adapting a method for the detection of APs for use in a laboratory, analysts should ensure successful validation experiments for appropriateness and completeness have been conducted, and perform additional experiments when indicated. Copyright © 2012 John Wiley & Sons, Ltd.
In vitro metabolism studies on mephedrone and analysis of forensic cases
Authors: Pedersen Anders Just , Reitzel Lotte Ask , Johansen Sys Stybe , Linnet Kristian 
Published: May 2012

The stimulant designer drug mephedrone is a derivative of cathinone – a monoamine alkaloid found in khat – and its effect resembles that of 3,4‐Methylenedioxymethamphetamine (MDMA). Abuse of mephedrone has been documented since 2007; it was originally a ‘legal high’ drug, but it has now been banned in most Western countries.Using cDNA‐expressed CYP enzymes and human liver microsomal preparations, we found that cytochrome P450 2D6 (CYP2D6) was the main responsible enzyme for the in vitro Phase I metabolism of mephedrone, with some minor contribution from other NAPDH‐dependent enzymes.Hydroxytolyl‐mephedrone and nor‐mephedrone were formed in vitro, and the former was purified and identified by nuclear magnetic resonance (NMR). In four forensic traffic cases where mephedrone was detected, we identified hydroxytolyl‐mephedrone and nor‐mephedrone again; as well as 4‐carboxy‐dihydro‐mephedrone, which has been previously described; and two new metabolites: dihydro‐mephedrone and 4‐carboxy‐mephedrone. Fragmentation patterns for all detected compounds were determined by a UPLC‐QTOF/MSE system, and a fragmentation pathway via a conjugated indole structure was proposed for most of the metabolites. Blood concentrations in the forensic traffic cases ranged from 1 to 51 µg/kg for mephedrone, and from not detected to 9 µg/kg for hydroxytolyl‐mephedrone. In one case, urine concentrations were also determined to be 700 µg/kg for mephedrone and 190 µg/kg for hydroxytolyl‐mephedrone. All compounds were detected or quantified with an ultra performance liquid chromatography‐tandem mass spectrometry (UPLC‐MS/MS) system and an ultra performance liquid chromatography‐time of flight/mass spectrometry (UPLC‐TOF/MS) system. Copyright © 2012 John Wiley & Sons, Ltd.
No evidence for niche segregation in a North American Cattail (Typha) species complex
Authors: McKenzie‐Gopsill Andrew , Kirk Heather , Drunen Wendy Van , Freeland Joanna R. , Dorken Marcel E. 
Published: May 2012

AbstractInterspecific hybridization can lead to a breakdown of species boundaries, and is of particular concern in cases in which one of the parental species is invasive. Cattails (Typha spp.) have increased their abundance in the Great Lakes region of North America over the past 150 years. This increase in the distribution of cattails is associated with hybridization between broad‐leaved (Typha latifolia) and narrow‐leaved cattails (T. angustifolia). The resulting hybrids occur predominantly as F1s, which are known as T. × glauca, although later‐generation hybrids have also been documented. It has been proposed that in sympatric populations, the parental species and hybrids are often spatially segregated according to growth in contrasting water depths, and that this should promote the maintenance of parental species. In this study, we tested the hypothesis that the two species and their hybrids segregate along a water‐depth gradient at sites where they are sympatric. We identified the two parental species and their hybrids using molecular genetic markers (SSR), and measured shoot elevations (a proxy for water depth) at 18 sites in Southern Ontario, Canada. We found no evidence for niche segregation among species based on elevation. Our data indicate that all three lineages compete for similar habitat where they co‐occur suggesting that there is potential for an overall loss of biodiversity in the species complex, particularly if the hybrid lineage is more vigorous compared to the parental species, as has been suggested by other authors.
Synthesis of Eight 1‐Deoxynojirimycin Isomers from a Single Chiral Cyanohydrin
Authors: van den Nieuwendijk Adrianus M. C. H. , van den Berg Richard J. B. H. N. , Ruben Mark , Witte Martin D. , Brussee Johannes , Boot Rolf G. , van der Marel Gijsbert A. , Aerts Johannes M. F. G. , Overkleeft Herman S. 
Published: May 2012

AbstractEight configurational 1‐deoxynojirimycin isomers have been synthesized starting from a chiral cyanohydrin as the common precursor. The cyanohydrin chiral pool building block is easily accessible in large quantities by using almond hydroxynitrile lyase as the chiral catalyst in condensing hydrogen cyanide and crotonaldehyde. Our work complements the large body of literature on the synthesis of 1‐deoxynojirimycin derivatives with the distinguishing feature that eight stereoisomers of this important class of glycosidase inhibitors can be derived from a common precursor in an efficient manner.
Deregulated expression of DNA polymerase β is involved in the progression of genomic instability
Authors: Luo Qingying , Lai Yanhao , Liu Shukun , Wu Mei , Liu Yuan , Zhang Zunzhen 
Published: May 2012

AbstractDeregulated expression of DNA polymerase beta (pol β) has been implicated in genomic instability that leads to tumorigenesis, yet the mechanisms underlying the pol β‐mediated genetic instability remain elusive. In this study, we investigated the roles of deregulated expression of pol β in spontaneous and xenobiotic‐induced genetic instability using mouse embryonic fibroblasts (MEFs) that express distinct pol β levels (wild‐type, null, and overexpression) as a model system. Three genetic instability endpoints, DNA strand breaks, chromosome breakage, and gene mutation, were examined under various expression levels of pol β by comet assay, micronuclei test, and hprt mutation assay. Our results demonstrate that neither pol β deficiency nor pol β overexpression is sufficient for accumulation of spontaneous DNA damage that promotes a hyperproliferation phenotype. However, pol β null cells exhibit increased sensitivity to exogenous DNA damaging agents with increased genomic instability compared with pol β wild‐type and overexpression cells. This finding suggests that a pol β deficiency may underlie genomic instability induced by exogenous DNA damaging agents. Interestingly, pol β overexpression cells exhibit less chromosomal or DNA damage, but display a higher hprt mutation frequency upon methyl methanesulfonate exposure compared with the other two cell types. Our results therefore indicate that an excessive amount of pol β may promote genomic instability, presumably through an error‐prone repair response, although it enhances overall BER capacity for induced DNA damage. Environ. Mol. Mutagen. 2012. © 2012Wiley Periodicals, Inc.