bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peningkatan Pengetahuan Siswa Sekolah Dasar tentang Bahan Tambahan Pangan Berbahaya dengan Metode Eksperimen Laboratorium
Authors: Chairunisa Ayu Saputri  , Erna Agung Rakhmawati  , Charlis Palupi  
Published: May 2024

Food Additives in general are to increase the nutritional value of food, improve the aesthetic and sensory value of food and extend the shelf life of food. There is abuse of food additives which can endanger consumers, such as adding borax and formaldehyde to food. This community service activity is an effort to increase elementary school students' knowledge of dangerous BTP using laboratory experimental methods. The results show that there is an increase in students' knowledge of dangerous food additives.
Hubungan Perilaku Asertif Dengan Kepuasan Pernikahan Pada Ibu Rumah Tangga
Authors: Roslim Fauziah , Zikra Zikra 
Published: May 2024

Penelitian ini dilatarbelakangi oleh fenomena beberapa orang responden mengaku sulit untuk terbuka dan mengekspresikan perasaan mereka kepada pasangan, sehingga komunikasi menjadi tidak efektif. Penelitian ini bertujuan untuk mendeskripsikan perilaku asertif ibu rumah tangga, mendeskripsikan bagaimana kepuasan pernikahan ibu rumah tangga, menguji apakah terdapat hubungan signifikan antara perilaku asertif dengan kepuasan pernikahan pada ibu rumah tangga. Penelitian ini merupakan jenis penelitian kuantitatif dengan pendekatan deskriptif korelasional. Populasi yang digunakan dalam penelitian ini sebanyak 249 ibu rumah tangga dengan sampel penelitian berjumlah 84 orang ibu rumah tangga dengan menggunakan teknik purposive sampling dengan kriteria sampel pasangan yang tinggal serumah, istri yang tidak bekerja atau ibu rumah tangga dengan rentang usia 23-40 tahun serta sudah mempunyai anak, usia pernikahan minimal 3-15 tahun, dan berdomisili di Desa Kampung Gadang. Pengumpulan data pada penelitian ini menggunakan instrumen kepuasan pernikahan sebanyak 45 item pernyataan dan instrumen perilaku asertif peneliti adopsi dari peneliti terdahulu sebanyak 28 item. Hasil penelitian ini menunjukkan bahwa perilaku asertif berada pada kategori tinggi dengan persentase (45%), kepuasan pernikahan yang dimiliki ibu rumah tangga berada pada kategori sedang dengan persentase (36%), hasil analisis korelasi terhadap hubungan yang signifikan antara perilaku asertif dengan kepuasan pernikahan pada ibu rumah tangga dengan r hitung sebesar 0,648 dengan taraf signifikansi sebesar ?0,001 pada tingkat hubungan yang kuat. Hubungan yang signifikan artinya semakin tinggi perilaku asertif ibu rumah tangga maka semakin tinggi pula kepuasan pernikahan ibu rumah tangga, sebaliknya semakin rendah perilaku asertif ibu rumah tangga maka semakin rendah pula kepuasan pernikahan ibu rumah tangga.
Prioritas Pengembangan Objek Wisata Bono berbasis Partisipasi Masyarakat dengan Pendekatan Analisis SOAR
Authors: Rosadini Natasya , Mariya Sri 
Published: May 2024

Pengembangan potensi pariwisata yang dilakukan oleh pemerintah memerlukan dukungan masyarakat dalam mempromosikan dan terlibat secara aktif. Potensi besar pariwisata yang ada di Kabupaten Pelalawan terdapat di Kecamatan Teluk Meranti yaitu Ombak Bono yang berlokasi di Sungai Kampar. Tujuan penelitian ini adalah untuk mengetahui karaktersitik objek wisata Bono, karakteristik partisipasi masyarakat dalam pengembangan objek wisata Bono serta rumusan prioritas pengembangan objek wisata Bono berbasis partisipasi masyarakat dengan pendekatan analisis SOAR. Penelitian ini menggunakan metode analisis deskriptif kualitatif pada sasaran 1 dan 2 serta analisis SOAR pada sasaran 3. Hasil dari penelitian ini menunjukkan karakteristik objek wisata Bono terdiri dari daya tarik wisata alami berupa Ombak Bono, fasilitas tempat penginapan berupa hotel dan homestay serta tempat peristirahatan berupa warung, sudah tersedia listrik dan jaringan telekomunikasi. Namun, disisi lain belum terdapat daya tarik wisata buatan, instalasi air bersih, tempat parkir, toilet umum dan sistem persampahan, kondisi jalan menuju objek wisata Bono sebagian masih berupa semenisasi. Karakteristik partisipasi masyarakat dalam pengembangan objek wisata Bono diidentifikasi bahwa masyarakat bersedia terlibat sebagai tenaga kerja, mempromosikan objek wisata Bono di media sosial dan melakukan gotong royong. Masyarakat tidak memberikan sumbangan dalam bentuk uang namun dengan cara menghibahkan tanah untuk pembangunan turap, membangun mushalla, menyediakan homestay, dan motor sebagai jasa ojek untuk mengantarkan wisatawan menuju lokasi objek wisata. Namun, disisi lain masyarakat kurang memberikan sumbangsih pendapat dan ide kepada pengelola wisata karena kurangnya forum pertemuan langsung maupun tidak langsung dalam membahas pengembangan objek wisata dan masyarakat belum berpartisipasi dalam keterampilan untuk pengembangan objek wisata Bono. Hasil dari prioritas pengembangan objek wisata Bono berbasis partisipasi masyarakat dengan menggunakan pendekatan analisis SOAR di dapatkan 8 prioritas yang dirumuskan diantaranya : (1) Menetapkan tarif layanan retribusi masuk wisata yang jelas untuk pendapatan wisata, (2) Mengadakan pelatihan manajemen dalam pengelolaan homestay untuk meningkatkan hospitality service, (3) Memperbaiki pembangunan akses jalan dan menyediakan papan penunjuk arah, (4) Mengadakan pelatihan terkait pariwisata untuk meningkatkan skill pelayanan wisata dan kepedulian masyarakat di bidang kepariwisataan, (5) Mengadakan pelatihan tentang penggunaan social media sebagai sarana promosi objek wisata, (6) Menciptakan daya tarik wisata baru, (7) Membangun warung, menyediakan layanan internet wifi, membuat instalasi air bersih, menyediakan tempat parkir dan membangun toilet, (8) Menambah jumlah tempat sampah dan menyediakan Tempat Pembuangan Akhir (TPA).
Orbital Infections and Infestations - A Narrative Review
Authors: Kaur Apjit , Ankita  
Published: May 2024

Introduction: Orbital infections and infestations present with varying clinical presentations and incidences ranging from benign ocular condition to disseminated systemic disease. The diagnosis is often difficult initially, due to similar ocular presentations.
Materials and methods: This review was compiled using articles available on PubMed using key words like orbital infections, orbital cellulitis, orbital infestations, orbital tuberculosis, orbital fungal infections. Clinical experience in presentation and management at our centre was also included.
Results: The varied presentations, management, complications and follow-ups have been summarised in this review.
Conclusion: As the management is cause-specific, thus lies the importance of early accurate diagnosis, both clinical and radiological. This article aims to review existing literature on orbital infections and infestations for aiding in early accurate diagnosis and management.
Bilateral Optic Neuritis in a Patient with Enteric Fever: A Case Report
Authors: Chhetri Sundip Dware , Vaidya Keepa , Lamichhane Suman , Rajbhandari Sudeep Lal , Katwal Shailendra 
Published: May 2024

Background: Bilateral optic neuritis following enteric fever is a rare condition requiring early evaluation by an ophthalmologist and prompt treatment for visual rehabilitation.
Case: A 31-year-old female diagnosed with enteric fever presented to the Neuro-ophthalmology department with sudden painful loss of vision in both eyes for 10 days.
Observations: Her Best Corrected Visual Acuity (BCVA) was counting fingers close to face in left eye and 6/18 in right eye. Posterior segment examination showed blurring of disc margin on both eyes. On Magnetic Resonance Imaging (MRI) of brain and orbit there was mild thickening of retro-orbital portions of both optic nerves. She was started on steroid therapy which resulted in marked improvement of vision in both eyes.
Conclusion: Optic neuritis following enteric fever is a rare entity and requires early diagnosis with prompt treatment for improvement of visual acuity and prevention of visual impairment.
UTILIZING SNAKES AND LADDERS MEDIA IN LEARNING MATHEMATIC ELEMENTARY SCHOOL STUDENTS
Authors: Ukhti Hanifah Tiarawati  , Sukartono  
Published: May 2024

This research is motivated by the selection of learning methods that are not appropriate, resulting in a lack of interest in learning in students, especially in mathematics. The fact found in the field is that teachers in learning activities only use the lecture method, this causes the learning to feel very monotonous so that students feel bored and lack interest in learning. The purpose of this study was to describe the use of snakes and ladders media in learning math with length, weight, and time material in standard units in grade 2 in elementary school. This research uses a qualitative approach with a case study design. This research data consists of primary data and secondary data. Data collection used interview, observation, and documentation techniques. Data validity used source triangulation and technique triangulation. Data analysis used the Miles and Huberman model which consists of data collection, data reduction, data presentation, and conclusion drawing. Based on the results of the study, it can be concluded that the use of snakes and ladders media in learning mathematics material on length, weight, and time in standard units can foster students' interest in learning. The selection of media in the form of a snakes and ladders game can foster students' interest in learning which is indicated by the interest, enthusiasm, and enthusiasm of students in playing the media and involving the active role of students so that learning is fun.
Proses Metakognisi Siswa SMP dalam Pemecahan Masalah Perbandingan Senilai dan Berbalik Nilai
Authors: Setyaningrum Defi U , Mampouw Helti L 
Published: May 2024

Proses metakognisi yakni awareness, regulation, dan evaluation menjadi bagian penentu keberhasilan siswa dalam memecahkan masalah. Tujuan penelitian ini adalah mendeskripsikan proses metakognisi siswa SMP dalam memecahkan masalah perbandingan senilai dan berbalik nilai. Penelitian ini merupakan penelitian deskriptif kualitatif. Subjek penelitian terdiri dari 3 siswa SMP Negeri 2 Tengaran yang masing-masing berkemampuan matematika tinggi, sedang dan rendah. Pengumpulan data dilakukan menggunakan tes dan wawancara. Hasil penelitian menunjukkan proses awareness ketiga subjek adalah mampu menggunakan pengetahuan awal yang dapat membantunya untuk memecahkan masalah. Proses regulation subjek berkemampuan matematika tinggi dan sedang sama-sama mampu merencanakan dan berfikir ulang langkah yang akan digunakan untuk memecahkan masalah, di mana hal ini tidak muncul pada subjek berkemamuan matematika rendah. Pada proses evaluation, subjek berkemampuan tinggi mampu memiliki cara lain dalam pemecahan, subjek berkemampuan matematika sedang mampu menyelesaikan masalah dan merevisi beberapa kesalahan, sedangkan subjek berkemampuan matematika rendah tidak mengalami proses ini dan tidak menyadari kesalahannya dalam memecahkan masalah perbandingan berbalik nilai.
The metacognition process, namely awareness, regulation, and evaluation, is a critical determinant of student success in solving problems. The purpose of this study is to describe the process of metacognition of junior high school students in solving problems of comparative worth and turn around values. This research is a qualitative descriptive study. The subjects of the study consisted of 3 students from SMP Negeri 2 Tengaran, each with high, medium, and low mathematical abilities. Data collection was carried out using tests and interviews. The results showed that the awareness process of the three subjects was able to use initial knowledge that could help him to solve problems. The process of regulation of subjects with high mathematical ability and being equally able to plan and rethink steps that will be used to solve problems, where this does not appear on subjects with low mathematical ability. In the evaluation process, high-skilled subjects can have other ways of solving, mathematical-capable subjects can solve problems and revise some errors, while low-mathematical-capable subjects do not experience this process and are unaware of their mistakes in solving the problem of reversing value comparison.
Perbandingan TAI dan NHT terhadap Hasil Belajar Trigonometri Ditinjau dari Kecerdasan Interpersonal
Authors: Setiawan Yoga , Prihatnani Erlina 
Published: May 2024

Setiap model pembelajaran kooperatif memiliki karakteristik dalam menerapkan enam prinsip pembelajaran kooperatif termasuk model Team Assisted Individualization (TAI) dan Numbered Heads Together (NHT). Tujuan penelitian ini untuk mengetahui manakah yang menghasilkan hasil belajar yang lebih baik diantara (1) model TAI dan NHT, (2) tingkat kecerdasan interpersonal, dan (3) interaksi model pembelajaran TAI dan NHT dengan kecerdasan interpersonal. Populasi penelitian adalah seluruh siswa kelas X SMA N 1 Salatiga Tahun Ajaran 2018/2019 (384 siswa). Melalui teknik cluster random sampling diperoleh 30 siswa kelas X IPS 1 sebagai kelas eksperimen 1 dan 34 siswa kelas X IPS 2 sebagai kelas eksperimen 2 dengan perbedaan perlakuan dalam pembelajaran trigonometri. Penelitian eksperimen semu ini menggunakan randomized control group pretest-postest design. Uji hipotesis menyimpulkan (1) hasil belajar siswa dengan model TAI secara signifikan lebih baik daripada NHT, (2) tidak ada perbedaan hasil belajar yang signifikan dari tingkat kecerdasan interpersonal yang berbeda, (3) tidak terdapat interaksi antara model pembelajaran dengan kecerdasan interpersonal terhadap hasil belajar.
Each type of cooperative learning model has different characteristics in applying 6 principles of cooperative learning, including TAI (Team Assisted Individualization) and NHT (Numbered Head Together) type models. This study aimed to find out: (1) which learning outcomes are better between students using the TAI or NHT models, (2) which learning outcomes are better between students with high, medium and low interpersonal intelligence levels, (3) is there any correlation between TAI and NHT learning models with interpersonal intelligence on student learning outcomes. The population in this study were all students of X grade at SMA N 1 Salatiga in the Academic Year 2018/2019 (384 students). Through assembling random sampling techniques obtained students of class X IPS 1 (30 students) as experimental class I and students of class X IPS 2 (34 students) as experimental class II with different treatment in learning mathematics on trigonometry material. This quasi-experimental research used a randomized control group pretest-posttest design. Hypothesis test results concluded that (1) student learning outcomes with the TAI model were significantly better than student learning outcomes with the NHT model, (2) there was no significant difference between student learning outcomes of different levels of interpersonal intelligence, (3) there were no interactions between models learning with interpersonal intelligence on student learning outcomes.
Bioactive peptides as alternative treatment for Helicobacter pylori infection
Authors: Franca-Oliveira Giselle , Hernández-Ledesma Blanca , Martinez-Rodriguez Adolfo 
Published: May 2024

The infection and chronic inflammatory response generated by Helicobacter pylori is a global health concern. This pathogen is characterized as a major risk factor in the development of gastric cancer and other diseases. Conventional eradication therapies are based on antibiotic regimens and as a consequence there is an increase in antimicrobial resistance of the pathogen strains, besides other potential side effects for the host. Therefore, it is necessary to explore new alternatives. This review delves into the realm of antimicrobial peptides, exploring their efficacy against H. pylori sourced from diverse origins. Furthermore, it sheds light on food-derived peptides exhibiting remarkable biological activity. These peptides exhibit promising effects on biomarkers associated with H. pylori infection, demonstrating anti-inflammatory and antioxidant properties validated through rigorous testing in both cell and animal models. Regarding the anti-inflammatory activity, the peptide VPY derived from soybean and the peptides derived from animal sources such as meat (β-Ala-His), egg (DEDTQAMPFR, DEDTQAMPF, MLGATSL, MSYSAGF, CR, FL, HC, LL, MK) and milk (IPAV) have reported a reduction of the cytokine IL-8, biomarker directly related to H. infection. For the antioxidant activity, peptides derived from milk (EAMAPK, AVPYPQ) and from Spirulina maxima (LDAVNR, MMLDF) have reduced ROS levels and could have a positive effect on the control of H. infection. Food-derived bioactive peptides with an anti-adhesive effect were also discussed. They derive from vegetable sources (corn, pea and wheat) and are capable of interacting with the host cells, interfering the adherence of H. pylori. Food-derived bioactive peptides have potential to avoid and/or mitigate undesired outcomes of infectious diseases due to the possibility of its application in nutraceuticals and food products, resulting in a preventive approach.
Keywords: Helicobacter pylori, antibiotic resistance, bioactive peptides, antimicrobial peptides
Extracellular Vesicle-Enriched miRNA-Biomarkers Show Improved Utility for Detecting Alzheimer’s Disease Dementia and Medial Temporal Atrophy
Authors: Chai Yuek Ling , Strohm Lea , Zhu Yanan , Chia Rachel S.L. , Chong Joyce Ruifen , Suresh Danesha Devini , Zhou Li Han , Too Heng Phon , Hilal Saima , Radivoyevitch Tomas , Koo Edward H. , Chen Christopher P. , Poplawski Gunnar Heiko Dirk 
Published: May 2024

Background: Emerging diagnostic modalities suggest that miRNA profiles within extracellular vesicles (EVs) isolated from peripheral blood specimens may provide a non-invasive diagnostic alternative for dementia and neurodegenerative disorders. Given that EVs confer a protective environment against miRNA enzymatic degradation, the miRNAs enriched in the EV fraction of blood samples could serve as more stable and clinically relevant biomarkers compared to those obtained from serum. Objective: To compare miRNAs isolated from EVs versus serum in blood taken from Alzheimer’s disease (AD) dementia patients and control cohorts. Methods: We compared 25 AD patients to 34 individuals who exhibited no cognitive impairments (NCI). Subjects were Singapore residents with Chinese heritage. miRNAs purified from serum versus blood-derived EVs were analyzed for associations with AD dementia and medial temporal atrophy detected by magnetic resonance imaging. Results: Compared to serum-miRNAs, we identified almost twice as many EV-miRNAs associated with AD dementia, and they also correlated more significantly with medial temporal atrophy, a neuroimaging marker of AD-brain pathology. We further developed combination panels of serum-miRNAs and EV-miRNAs with improved performance in identifying AD dementia. Dominant in both panels was miRNA-1290. Conclusions: This data indicates that miRNA profiling from EVs offers diagnostic superiority. This underscores the role of EVs as vectors harboring prognostic biomarkers for neurodegenerative disorders and suggests their potential in yielding novel biomarkers for AD diagnosis.
Caffeoylquinic Acid Mitigates Neuronal Loss and Cognitive Decline in 5XFAD Mice Without Reducing the Amyloid-β Plaque Burden
Authors: Suganuma Takaya , Hatori Sena , Chen Chung-Kuan , Hori Satoshi , Kanuka Mika , Liu Chih-Yao , Tatsuzawa Chika , Yanagisawa Masashi , Hayashi Yu 
Published: May 2024

Background: Caffeoylquinic acid (CQA), which is abundant in coffee beans and Centella asiatica, reportedly improves cognitive function in Alzheimer’s disease (AD) model mice, but its effects on neuroinflammation, neuronal loss, and the amyloid-β (Aβ) plaque burden have remained unclear. Objective: To assess the effects of a 16-week treatment with CQA on recognition memory, working memory, Aβ levels, neuronal loss, neuroinflammation, and gene expression in the brains of 5XFAD mice, a commonly used mouse model of familial AD. Methods: 5XFAD mice at 7 weeks of age were fed a 0.8% CQA-containing diet for 4 months and then underwent novel object recognition (NOR) and Y-maze tests. The Aβ levels and plaque burden were analyzed by enzyme-linked immunosorbent assay and immunofluorescent staining, respectively. Immunostaining of markers of mature neurons, synapses, and glial cells was analyzed. AmpliSeq transcriptome analysis and quantitative reverse-transcription-polymerase chain reaction were performed to assess the effect of CQA on gene expression levels in the cerebral cortex of the 5XFAD mice. Results: CQA treatment for 4 months improved recognition memory and ameliorated the reduction of mature neurons and synaptic function-related gene mRNAs. The Aβ levels, plaque burden, and glial markers of neuroinflammation seemed unaffected. Conclusions: These findings suggest that CQA treatment mitigates neuronal loss and improves cognitive function without reducing Aβ levels or neuroinflammation. Thus, CQA is a potential therapeutic compound for AD, improving cognitive function via as-yet unknown mechanisms independent of reductions in Aβ or neuroinflammation.
Vascular Risk Factors and Brain Health in Aging: Insights from a Community-Based Cohort Study
Authors: Wang Wenxiao , Yang Yiru , Sang Feng , Chen Yaojing , Li Xin , Chen Kewei , Wang Jun , Zhang Zhanjun 
Published: May 2024

Background: The aging population and high rates of Alzheimer’s disease (AD) create significant medical burdens, prompting a need for early prevention. Targeting modifiable risk factors like vascular risk factors (VRFs), closely linked to AD, may provide a promising strategy for intervention. Objective: This study investigates how VRFs influence cognitive performance and brain structures in a community-based cohort. Methods: In this cross-sectional study, 4,667 participants over 50 years old, drawn from the Beijing Ageing Brain Rejuvenation Initiative project, were meticulously examined. Cognitive function and VRFs (diabetes mellitus, hypertension, hyperlipidemia, obesity, and smoking), were comprehensively assessed through one-to-one interviews. Additionally, a subset of participants ( n = 719) underwent MRI, encompassing T1-weighted and diffusion-weighted scans, to elucidate gray matter volume and white matter structural network organization. Results: The findings unveil diabetes as a potent detriment to memory, manifesting in atrophy within the right supramarginal gyrus and diminished nodal efficiency and degree centrality in the right inferior parietal lobe. Hypertension solely impaired memory without significant structural changes. Intriguingly, individuals with comorbid diabetes and hypertension exhibited the most pronounced deficits in both brain structure and cognitive performance. Remarkably, hyperlipidemia emerged as a factor associated with enhanced cognition, and preservation of brain structure. Conclusions: This study illuminates the intricate associations between VRFs and the varied patterns of cognitive and brain structural damage. Notably, the synergistic effect of diabetes and hypertension emerges as particularly deleterious. These findings underscore the imperative to tailor interventions for patients with distinct VRF comorbidities, especially when addressing cognitive decline and structural brain changes.