bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transglutaminase 2 serves as a pathogenic hub gene of KRAS mutant colon cancer based on integrated analysis
Authors: Peng Wei-Bin , Li Yu-Ping , Zeng Yong , Chen Kai 
Published: May 2024

BACKGROUND
Colon cancer is acknowledged as one of the most common malignancies worldwide, ranking third in United States regarding incidence and mortality. Notably, approximately 40% of colon cancer cases harbor oncogenic KRAS mutations, resulting in the continuous activation of epidermal growth factor receptor signaling.
AIM
To investigate the key pathogenic genes in KRAS mutant colon cancer holds considerable importance.
METHODS
Weighted gene co-expression network analysis, in combination with additional bioinformatics analysis, were conducted to screen the key factors driving the progression of KRAS mutant colon cancer. Meanwhile, various in vitro experiments were also conducted to explore the biological function of transglutaminase 2 (TGM2).
RESULTS
Integrated analysis demonstrated that TGM2 acted as an independent prognostic factor for progression-free survival. Immunohistochemical analysis on tissue microarrays revealed that TGM2 was associated with an elevated probability of perineural invasion in patients with KRAS mutant colon cancer. Additionally, biological roles of the key gene TGM2 was also assessed, suggesting that the downregulation of TGM2 attenuated the proliferation, invasion, and migration of the KRAS mutant colon cancer cell line.
CONCLUSION
This study underscores the potential significance of TGM2 in the progression of KRAS mutant colon cancer. This insight not only offers a theoretical foundation for therapeutic approaches but also highlights the need for additional clinical trials and fundamental research to support our preliminary findings.
MiRNA-145-5p inhibits gastric cancer progression via the serpin family E member 1- extracellular signal-regulated kinase-1/2 axis
Authors: Bai Hong-Xia , Qiu Xue-Mei , Xu Chun-Hong , Guo Jian-Qiang 
Published: May 2024

BACKGROUND
MicroRNAs (miRNAs) regulate gene expression and play a critical role in cancer physiology. However, there is still a limited understanding of the function and regulatory mechanism of miRNAs in gastric cancer (GC).
AIM
To investigate the role and molecular mechanism of miRNA-145-5p (miR145-5p ) in the progression of GC.
METHODS
Real-time polymerase chain reaction (RT-PCR) was used to detect miRNA expression in human GC tissues and cells. The ability of cancer cells to migrate and invade was assessed using wound-healing and transwell assays, respectively. Cell proliferation was measured using cell counting kit-8 and colony formation assays, and apoptosis was evaluated using flow cytometry. Expression of the epithelial-mesenchymal transition (EMT)-associated protein was determined by Western blot. Targets of miR-145-5p were predicated using bioinformatics analysis and verified using a dual-luciferase reporter system. Serpin family E member 1 (SERPINE1 ) expression in GC tissues and cells was evaluated using RT-PCR and immunohistochemical staining. The correlation between SERPINE1 expression and overall patient survival was determined using Kaplan-Meier plot analysis. The association between SERPINE1 and GC progression was also tested. A rescue experiment of SERPINE1 overexpression was conducted to verify the relationship between this protein and miR-145-5p . The mechanism by which miR-145-5p influences GC progression was further explored by assessing tumor formation in nude mice.
RESULTS
GC tissues and cells had reduced miR-145-5p expression and SERPINE1 was identified as a direct target of this miRNA. Overexpression of miR-145-5p was associated with decreased GC cell proliferation, invasion, migration, and EMT, and these effects were reversed by forcing SERPINE1 expression. Kaplan-Meier plot analysis revealed that patients with higher SERPINE1 expression had a shorter survival rate than those with lower SERPINE1 expression. Nude mouse tumorigenesis experiments confirmed that miR-145-5p targets SERPINE1 to regulate extracellular signal-regulated kinase-1/2 (ERK1/2).
CONCLUSION
This study found that miR-145-5p inhibits tumor progression and is expressed in lower amounts in patients with GC. MiR-145-5p was found to affect GC cell proliferation, migration, and invasion by negatively regulating SERPINE1 levels and controlling the ERK1/2 pathway.
Hotspots and trends of risk factors in gastric cancer: A visualization and bibliometric analysis
Authors: Li Meng , Gao Ning , Wang Shao-Li , Guo Yu-Feng , Liu Zhen 
Published: May 2024

BACKGROUND
The lack of specific symptoms of gastric cancer (GC) causes great challenges in its early diagnosis. Thus it is essential to identify the risk factors for early diagnosis and treatment of GC and to improve the survival rates.
AIM
To assist physicians in identifying changes in the output of publications and research hotspots related to risk factors for GC, constructing a list of key risk factors, and providing a reference for early identification of patients at high risk for GC.
METHODS
Research articles on risk factors for GC were searched in the Web of Science core collection, and relevant information was extracted after screening. The literature was analyzed using Microsoft Excel 2019, CiteSpace V, and VOSviewer 1.6.18.
RESULTS
A total of 2514 papers from 72 countries and 2507 research institutions were retrieved. China (n = 1061), National Cancer Center (n = 138), and Shoichiro Tsugane (n = 36) were the most productive country, institution, or author, respectively. The research hotspots in the study of risk factors for GC are summarized in four areas, namely: Helicobacter pylori (H. pylori ) infection, single nucleotide polymorphism, bio-diagnostic markers, and GC risk prediction models.
CONCLUSION
In this study, we found that H. pylori infection is the most significant risk factor for GC; single-nucleotide polymorphism (SNP) is the most dominant genetic factor for GC; bio-diagnostic markers are the most promising diagnostic modality for GC. GC risk prediction models are the latest current research hotspot. We conclude that the most important risk factors for the development of GC are H. pylori infection, SNP, smoking, diet, and alcohol.
Metastatic pancreatic and lung cancer patient in complete remission following immunotherapy: A case report and review of literature
Authors: Martínez-Galán Joaquina , Jiménez-Luna Cristina , Rodriguez Isabel , Maza Elisabeth , García-Collado Carlos , Rodríguez-Fernández Antonio , López-Hidalgo Javier Luis , Caba Octavio 
Published: May 2024

BACKGROUND
Metastatic pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with dispiriting survival data. Immunotherapy is a promising approach to many cancer types, but achieves poor outcomes in advanced PDAC due to its immunosuppressive tumor microenvironment. We describe a case of metastatic PDAC effectively treated with pembrolizumab.
CASE SUMMARY
We report the case of a 67-year-old woman with unresectable locally advanced PDAC, treated with gemcitabine plus nab-paclitaxel followed by radiotherapy plus capecitabine. At nine months, pancreatic tumor progression was observed at the level of the hepatic hilum with the appearance of a new pulmonary nodule suggestive of a second primary, confirmed by left lung biopsy. Systemic immunotherapy was then initiated with pembrolizumab, an immune checkpoint inhibitor targeting programmed cell death protein-1 that covers the two tumor types. The patient showed a complete metabolic response that was maintained throughout the treatment. The patient continues to be disease-free at 5.6 years since the start of immunotherapy.
CONCLUSION
These results suggest that the administration of pembrolizumab after chemoradiotherapy has a beneficial effect in patients with metastatic PDAC. To our knowledge, this is the first reported case of a patient with metastatic PDAC and metastatic lung cancer showing such a long-lasting complete response after pembrolizumab treatment without curative surgery. Further studies are required to determine biomarkers that identify PDAC patients most likely to benefit from this immunotherapy.
Videomapping narrativo como estrategia cultural y turística pos-pandemia en la ciudad de Oaxaca, México
Authors: Lopez Altamirano Otniel , Montes Ponce Wendy , Soares Guimarães Márcio , Martínez Osorio Pedro 
Published: May 2024

El turismo es una de las actividades con mayores derramas económicas en el estado de Oaxaca en México, por lo que su reactivación social y económica son ejes prioritarios tras la pandemia generada por la COVID-19. Para contribuir en tal premisa, este anteproyecto se desdobló a partir de una metodología inductiva bajo tres variables: el medio, el contenido, y el espacio; que en conjunto proponen un espectáculo público, el cual, eventualmente tenga posibilidades de ser ejecutado, con el objetivo de diversificar la oferta cultural en la capital, tanto para locales, como para visitantes; asimismo, agregar valor al sector turístico. La primera variable es, el medio, considerando al videoproyector como una herramienta digital performativa que permite intervenciones en gran formato; la segunda, el espacio, uno de los sitios arquitectónicos con mayor reconocimiento patrimonial en la ciudad que cumpliría la función de pantalla y escenario; por último, el contenido, a través de la narrativa audiovisual que destaca aspectos socioculturales y tradicionales.
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Analisis Komunikasi Budaya Dalam Kesenian Senjang (Studi Pada Sanggar Putri Sak Ayu di Musi Banyuasin)
Authors: Riani Okta , Hamidah Hamidah , Hamandia Muhammad Randicha 
Published: May 2024

Penelitian ini berjudul “Analisis Komunikasi Budaya Dalam Kesenian Senjang Studi Pada Sanggar Putri Sak Ayu Di Musi Banyuasin” dengan permasalahan pokok dalam penelitian ini adalah bagaimana komunikasi budaya terhadap kesenian senjang pada Sanggar Putri Sak Ayu Di Musi Banyuasin, berdasarkan dengan permasalahan tersebut maka tujuan peneliti ialah Penelitian ini bertujuan untuk mengetahui dan menganalisis komunikasi budaya pada kesenian senjang di Musi Banyuasin. Melalui penelitian ini peneliti akan mengetahui dan memahami komunikasi budaya pada kesenian senjang Putri Sak Ayu di Musi Banyuasin. Dalam penelitian ini penulis menggunakan teori semiotik Riffateree. Semiotik adalah ilmu tentang tandatanda. Secara konsepsi menyatakan bahwa tanda adalah sesuatu yang mewakili sesuatu yang lain, yakni dapat berupa pengalaman, pikiran, perasaan, gagasan dan lain-lain. Dengan teknik pengumpulan data observasi, wawancara dan dokumentasi. Hasil dari penelitian menunjukan bahwa (1) kesenian senjang telah menjadi daya komunikasi bagi masyarakat luar kota maupun di dalam kota, dikarenakan kesenian senjang ini bersifat menyampaikan pesan kepada para pendengar dengan maksud tertentu. (2) Masyarakat Kabupaten Musi Banyuasin sangat apresiasi dengan adanya sanggar putri sak ayu yang dibawah pimpinan kantor Dinas Pendidikan dan Kebudayaan.
Running-Specific Prosthesis
Authors: Olatosi Oluranti 
Published: May 2024

Sports help children “develop physical skills that contribute to a lifetime of physical involvement; … learn social and emotional skills; develop moral values; and acquire a better sense of self through increased perceived competence, self-esteem, and self-confidence” (Ewing, Gano-Overway, Branta, & Seefeldt, 2002). Lower-leg amputations jeopardize children’s ability to continue participating in sports, as it removes a part of the body that is essential for running and sports participation. Running-specific prostheses (RSPs), a type of lower-limb prosthesis, provide a solution to this issue. Compared to daily-use prosthetics, running-specific prosthetics have a higher energy-storage capacity, are more flexible, and are more springy, allowing them to mimic the nature of running biological legs better than daily-use prosthetics. RSPs also have customizations that are specific to the physical traits and activity of an amputee, allowing an amputee to play a plethora of sports. Although children must overcome challenges regarding the change in biomechanics while running with an RSP and accounting for the rapid growth of children, RSPs can provide amputees the opportunity to return to the sports environment.
VIOLÊNCIA ESCOLAR: BREVE REFLEXÃO SOBRE AS CONSEQUÊNCIAS PARA O PROCESSO DE ENSINO E DE APRENDIZAGEM
Authors: Carneiro Núbia Célia 
Published: May 2024

As escolas do ensino básico têm sido alvo de diversos atos de violência, o que tem gerado preocupações na comunidade escolar e nas pessoas que frequentam esse ambiente diariamente. Este artigo tem como objetivo fazer uma breve reflexão sobre a violência no ambiente escolar e o seu impacto no processo de ensino e de aprendizagem. Enfatizando que a violência presente nesse ambiente afeta as relações interpessoais entre os sujeitos/estudantes. Pode-se compreender que o combate à violência é uma responsabilidade primordial dos poderes públicos, promovendo políticas públicas sociais para erradicar esse fenômeno. A falta de eficiência dessas políticas tem um impacto negativo na sociedade como um todo, sobretudo, para o processo de ensino e de aprendizagem. Nesse contexto, é fundamental que os professores sejam capacitados para identificar comportamentos agressivos e tomar decisões corretas para coibir quando eles ocorrerem. A metodologia empregada para a realização deste estudo consistiu em uma pesquisa do tipo bibliográfica, de autores com larga expertise na área educacional, tais como Abramovay (2009), Fante (2011), Lopes Neto (2011), Silva (2015), entre outros.
Response patterns of moss to atmospheric nitrogen deposition and nitrogen saturation in an urban–agro–forest transition
Authors: Deng Ouping , Chen Yuanyuan , Zhao Jingze , Li Xi , Zhou Wei , Lan Ting , Ou Dinghua , Zhang Yanyan , Liu Jiang , Luo Ling , He Yueqiang , Yang Hanqing , Huang Rong 
Published: May 2024

Abstract. Increasing trends of atmospheric nitrogen (N) deposition resulting from a large number of anthropogenic emissions of reactive N are dramatically altering the global biogeochemical cycle of N. Nitrogen uptake by mosses occurs mainly from the atmosphere, making it a competent bio-indicator of N deposition. However, high uncertainties exist when using mosses to indicate N deposition, especially in choosing sampling periods and sampling frequencies. In this study, atmospheric N deposition and moss N content in the urban–agro–forest transition, a region with a high N deposition level of 27.46–43.70 kg N hm−2 yr−1, were monitored, and the method for monitoring atmospheric N deposition by mosses was optimized. We found that the optimal sampling frequency is within 6 months per time, and the optimal sampling times are winter (January and February), autumn (October and November), and summer (July and August), which provides us with a more accurate estimation of atmospheric N deposition than other scenarios. In addition, the moss N content serves as a more reliable N species. This study eventually allowed mosses to be used more effectively and sensibly as an indicator of atmospheric N deposition and helped to improve the accuracy of the model for quantifying N deposition.
Emission ensemble approach to improve the development of multi-scale emission inventories
Authors: Thunis Philippe , Kuenen Jeroen , Pisoni Enrico , Bessagnet Bertrand , Banja Manjola , Gawuc Lech , Szymankiewicz Karol , Guizardi Diego , Crippa Monica , Lopez-Aparicio Susana , Guevara Marc , De Meij Alexander , Schindlbacher Sabine , Clappier Alain 
Published: May 2024

Abstract. Many studies have shown that emission inventories are one of the inputs with the most critical influences on the results of air quality modelling. Comparing emission inventories among themselves is, therefore, essential to build confidence in emission estimates. In this work, we extend the approach of Thunis et al. (2022) to compare emission inventories by building a benchmark that serves as a reference for comparisons. This benchmark is an ensemble that is based on three state-of-the-art EU-wide inventories: CAMS-REG, EMEP and EDGAR. The ensemble-based methodology screens differences between inventories and the ensemble. It excludes differences that are not relevant and identifies among the remaining ones those that need special attention. We applied the ensemble-based screening to both an EU-wide and a local (Poland) inventory. The EU-wide analysis highlighted a large number of inconsistencies. While the origin of some differences between EDGAR and the ensemble can be identified, their magnitude remains to be explained. These differences mostly occur for SO2 (sulfur oxides), PM (particulate matter) and NMVOC (non-methane volatile organic carbon) for the industrial and residential sectors and reach a factor of 10 in some instances. Spatial inconsistencies mostly occur for the industry and other sectors. At the local scale, inconsistencies relate mostly to differences in country sectorial shares that result from different sectors/activities being accounted for in the two types of inventories. This is explained by the fact that some emission sources are omitted in the local inventory due to a lack of appropriate geographically allocated activity data. We identified sectors and pollutants for which discussion between local and EU-wide emission compilers would be needed in order to reduce the magnitude of the observed differences (e.g. in the residential and industrial sectors). The ensemble-based screening proved to be a useful approach to spot inconsistencies by reducing the number of necessary inventory comparisons. With the progressive resolution of inconsistencies and associated inventory improvements, the ensemble will improve. In this sense, we see the ensemble as a useful tool to motivate the community around a single common benchmark and monitor progress towards the improvement of regionally and locally developed emission inventories.
Comparative analysis of serum titanium level in patient with healthy dental implant and patients with peri-implantitis- A cross sectional prospective study
Authors: S Mahantesha , Shetty Vibha , K Kranti , Subbaiah Shobha , C Greeshma , Alva Babashankar , Sharma Manish 
Published: May 2024

Objectives: Titanium dental implants can last for more than two decades in the oral environment. Corrosion of the implant surface can release metallic particles or ions into surrounding tissue. The metallic constituents like titanium in human blood serum have not been fully studied. The study compares titanium serum levels before and after dental implant placement and compares levels in patients with healthy implants and those with per-implantitis.
Methods: The study comprised 2groups of Group 1 patient observing implant surgery and group 2 patients with diagnosed peri-implantitis. Each group comprised of 60 patients. Serum titanium level was measured from blood obtained from Group 1 at three different intervals (one month prior to implant surgery, 4th and 8th month after successful loading) and from Group 2 during the course of peri-implantitis by inductively coupled plasma–mass spectroscopy. The statistical analysis was done for the obtained data.
Results: Analysis showed a raised level of serum titanium at 4th month of post implant placement (2.39 mg/dl) and in patient with peri-implantitis(2.94 mg/dl) and both levels are significantly differ (ANOVA test) from pre-surgical estimation of serum titanium level (1.79 mg/dl).
Conclusions: Understanding the correlation between titanium corrosion and peri-implantitis is vital for enhancing the long-term success and safety of dental implants. Additional research is required to investigate these links and potential strategies to protect the well-being of implant patients.
The use of biocidal products to control urban pests and vector arthropods
Authors: Drago A , Martini S. , Dutto M. 
Published: May 2024

Abstract
Pest management and vector control are important for their impact on health, quality of life, and the economy of touristic areas. The many different methods with which insecticides are applied, the specific equipment required, and the lack of clear terms often give rise to confusion and misunderstandings. This paper organises and describes their application methods, equipment, and most suitable use, and highlights their strengths and weaknesses.
Sosialisasi Keselamatan Instalasi Listrik Bertegangan Rendah Kepada Warga Peduli Sekitar (Wa Pesek) Kecamatan Medan Johor
Authors: Fadlan Siregar Muhammad , Satria Habib , Dayana Indri , Mungkin Moranain , Maizana Dina , Anwar Syaputra Sofyan , Fitriani Ayu , Syafriwel  , Permata Sari Siregar Ade 
Published: May 2024

Instalasi listrik harus sesuai dengan ketentuan Puil 2011 dimana menjamin kehandalan instalasi listrik sesuai tujuan pada pengguna listrik PLN. Instalas yang baik sesuai dengan ketentuanakan mencegah timbulnya bahaya kebakaran dan sentuhan langsung, penggunaan pada instalasi listrik yang dilengkapi dengan perlindungan dan keamanan seperti mini circuit beker, saklar diferensial (RCD), dan sistem grounding yang baik akan membantu melindungi rumah dari risiko kebakaran atau kecelakaan listrik. Hindari penggunaan kabel yang rusak atau terlalu panjang. Menggunakan alat - alat pelindung diri (APD) seperti sarung tangan dan sepatu khusus saat melakukan pekerjaan yang melibatkan penggunaan energi listrik keselamatan kerja listrik adalah tanggung jawab kita bersama. patuhi syarat-syarat keselamatan listrik.
Edukasi Tentang Cita-Cita dan Masa Depan Melalui Papan Cita Sebagai Upaya Mengatasi Kurangnya Minat Belajar di SDN 3 Bandar Baro
Authors: Safriana Safriana , Hajrayanti Lili , Azriansyah Akmal , Da’are Maesa Arik Uru , Padlu Rohman Cecep , Puspasari Cindenia , Irfan Ade 
Published: May 2024

Kurangnya edukasi dan dukungan dari lingkungan membuat kalangan siswa di daerah pelosok, salah satunya di SDN 3 Banda Baro mendorong para mahasiswa kelompok 1 Meutuah untuk melakukan kontribusi sosial di sekolah dasar ini dengan tujuan memotivasi dan mendorong para siswa untuk melanjutkan pendidikan hingga jenjang kuliah. Metode yang digunakan adalah dengan mengajak para siswa membuat papan cita-cita. Secara umum kegiatan pengabdian di SDN 3 Banda baro berjalan lancar, kondusif dan diterima dengan baik oleh pihak sekolah, pendampingan siswa dalam kontribusi sosial telah dapat meningkatkan antusias dan motivasi belajar siswa untuk meraih cita-cita, dan dengan adanya project papan cita-cita dan gantungan profesi siswa akan lebih termotivasi untuk dapat mengembangkan pola pikir dan penampilannya dalam belajar sehingga nantinya akan timbul profesionalitas cita-cita yang siswa kelas 5 harapkan