bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Geometry and Nature of C─I···O─N Interactions in Perfluoroiodobenzene‐Pyridine N‐oxide Halogen‐Bonded Complexes
Authors: Rautiainen Juha Mikko , Valkonen Arto , Lundell Jan , Rissanen Kari , Puttreddy Rakesh 
Published: June 2024

AbstractThe N─Oxide oxygen in the 111 C─I···⁻O─N+ halogen bond (XB) complexes, formed by five perfluoroiodobenzene XB donors and 32 pyridine N‐oxides (PyNO) XB acceptors, exhibits three XB modes: bidentate, tridentate, and monodentate. Their C─I···O XB angles range from 148° to 180°, reflecting the iodine σ‐hole's structure‐guiding influence. The I···⁻O─N+ angles range from 87° to 152°. On the contrary, the I···⁻O─N+ angles have a narrower range from 107° to 125° in stronger monodentate N─I···⁻O─N+ XBs of N‐iodoimides and PyNOs. The C─I···⁻O─N+ systems exhibit a larger variation in I···⁻O─N+ angles due to weaker XB donor perfluoroiodoaromatics forming weak I···O XBs, which allows wider access to electron‐rich N‐O group regions. Density Functional Theory analysis shows that I···O interactions are attractive even when the I···⁻O─N+ angle is ≈80°. Correlation analysis of structural parameters showed that weak I···O XBs in perfluoroiodobenzene‐PyNO complexes affect the C─I bond via n(O)→σ*(C─I) donation less than the N─I bond via n(O)→σ*(N─I) donation in very strong I···O XBs of N‐iodoimide‐PyNO complexes. This implies that PyNOs' oxygen self‐tunes its XB acceptor property, dependent on the XB donor σ‐hole strength affecting the bonding denticity, geometry, and interaction energies.
Computational Design of 2D Phosphorus Nanostructures for Renewable Energy Applications: A Review
Authors: Er Chen‐Chen , Fung Cheng‐May , Chong Wei‐Kean , Lee Yong Jieh , Tan Lling‐Lling , Ang Yee Sin , Medhekar Nikhil V. , Chai Siang‐Piao 
Published: June 2024

AbstractElemental phosphorus in its various allotropes has received tremendous research attention recently due to its intriguing electronic and structural properties. Notably, the application of nanostructured materials to overcome the inherent flaws in bulk materials is promising. However, many challenges need to be addressed before its widespread implementation. Thus, a specific tenet to design novel and robust nanomaterials is a decisive factor in the desired outcome, and the most daunting task before realizing this is solving the Schrödinger equation. First principle density functional theory (DFT) calculations have emerged as an insightful and accurate design tool to investigate the structural, electronic, and possible synthesis scenarios of yet undiscovered materials at atomic levels. In this review, the basic principles and the importance of DFT are discussed, followed by a summary of recent advances in the first principle study of elemental phosphorus‐based nanomaterials. Elemental phosphorus‐based nanomaterials and their allotropes have attracted growing interest in the renewable energy community due to their modulable product selectivity. However, the understanding of the physical phenomena of allotropic modification is still lacking. Therefore, the aim is to motivate experimental researchers to conduct DFT studies and experiments to comprehend relevant engineered nanomaterials better. Finally, the challenges and potential future research directions for further theoretical and computational development of phosphorus‐based nanomaterials are outlined.
Soil profile distribution of nutrients in contrasting soils amended with struvite and other conventional phosphorus fertilizers
Authors: Simms Tatum , Brye Kristofor R. , Roberts Trenton L. , Greenlee Lauren F. 
Published: June 2024

AbstractPhosphorus (P) can be recovered from wastewater and used as an alternative fertilizer, namely, struvite [MgNH4PO4·6(H2O)]. However, the soil mobility of wastewater‐derived P and other nutrients needs to be evaluated. The objective of this study was to compare the vertical distribution of water‐soluble (WS) soil P and other nutrients from a synthetic‐wastewater‐derived electrochemically precipitated struvite (ECST) to that from a chemically precipitated struvite (CPST), triple superphosphate (TSP), monoammonium phosphate (MAP), and a control in six soils from Arkansas (AR; loam [L] and silt loam [SiL]), Missouri (MO; SiL 1 and SiL 2), and Nebraska (NE; sandy loam [SL] and SiL). A column‐leaching experiment was conducted with the six soils and five fertilizer‐P treatments. Water‐soluble (WS) P from the two struvite materials generally did not differ (p > 0.05) and was similar to that of MAP in the depths of 0–3, 3–6, and 6–10 cm, but was greater than that of TSP in the top 6 cm in four of the six soils. WS P from CPST in the MO‐SiL 2 and NE‐SL soils (6.6 and 12.7 mg kg−1, respectively) was larger than that from ECST, MAP, and TSP. In the AR‐L and MO‐SiL 1 soils, TSP was the only fertilizer‐P source that had increased WS P concentrations in the top 6 cm relative to the other fertilizer‐P sources. Results showed that ECST‐derived, WS P had similar soil profile distributions in the top 10 cm, suggesting that ECST will be equally protective of environmental health and leachate quality across multiple soil textures as other common fertilizer‐P sources.
Efficacy of red sunflower seed weevil resistance from inbred line cms HA 488 in single‐cross hybrids
Authors: Prasifka Jarrad R. , Hulke Brent S. 
Published: June 2024

AbstractSunflower line HA 488 (where HA is Helianthus annuus) is resistant to the red sunflower seed weevil, Smicronyx fulvus LeConte, with ≈80% less seed damage compared to susceptible lines. To determine the value of resistance in single‐cross hybrids, six hybrids were created by pollinating weevil‐resistant (cms HA 488, where cms cytoplasmic male sterile) or susceptible (cms HA 412HO) inbred lines with three putatively susceptible restorer lines (RHA 274, RHA 464, or RHA 468) and artificially infesting each with 30 weevils head−1. In 2021–2022, resistant hybrids from cms HA 488 reduced seed damage by ≈40%–50% for hybrids with RHA 274 or RHA 464. However, cms HA 488 did not reduce damage when crossed with RHA 468. Infestation of male‐fertile isogenic lines HA 488 and HA 412HO with 60 weevils head−1 showed resistance remained effective at 12–20 times economic thresholds. Results confirm the value of resistance to S. fulvus for sunflower hybrids but also suggest a need to further examine the role of the male heterotic group in resistance to the red sunflower seed weevil.
Enhancing cell‐based therapies with synthetic gene circuits responsive to molecular stimuli
Authors: Galvan Silvia , Teixeira Ana P. , Fussenegger Martin 
Published: June 2024

AbstractSynthetic biology aims to contribute to the development of next‐generation patient‐specific cell‐based therapies for chronic diseases especially through the construction of sophisticated synthetic gene switches to enhance the safety and spatiotemporal controllability of engineered cells. Indeed, switches that sense and process specific cues, which may be either externally administered triggers or endogenous disease‐associated molecules, have emerged as powerful tools for programming and fine‐tuning therapeutic outputs. Living engineered cells, often referred to as designer cells, incorporating such switches are delivered to patients either as encapsulated cell implants or by infusion, as in the case of the clinically approved CAR‐T cell therapies. Here, we review recent developments in synthetic gene switches responsive to molecular stimuli, spanning regulatory mechanisms acting at the transcriptional, translational, and posttranslational levels. We also discuss current challenges facing clinical translation of cell‐based therapies employing these devices.
Transcranial magnetic stimulation in the assessment of acupuncture effect on exercise‐induced fatigue
Authors: Hu Linghui , Wei Zhen , Wang Xiaolei , Wu Wei 
Published: June 2024

AbstractBackgroundAcupuncture as a traditional Chinese medicine therapy relies on unique theories to alleviate fatigue. The aim of this study is to evaluate the effect of acupuncture on exercise‐induced fatigue utilizing transcranial magnetic stimulation (TMS).MethodsA total of 20 participants with regular exercise habits were recruited for this study. All participants were randomly assigned to receive either acupuncture or sham acupuncture intervention for exercise‐induced fatigue. TMS and a heart rate monitor were used to measure the amplitude and latency of motor evoked potential (MEP) as well as heart rate every 5 min over a 30‐min period. The blood lactic acid (BLA) levels were measured using Lactate Scout+ at baseline, 0 min, and 30 min after fatigue. Two‐way repeated measures analysis of variance was utilized to compare the differences between the effects of acupuncture method and time. Bonferroni post hoc tests were conducted to compare specific differences. Statistical significance was set at p < .05.ResultsInteraction effect was observed between acupuncture method and time effect in terms of amplitude (F(1, 38) = 5.40, p < .001, η2 = 0.12) and latency (F(1, 38) = 3.78, p = .008, η2 = .09) of MEP. The application of acupuncture can promote the recovery of heart rate especially at 30 min (p < .05), but which seem insufficient to generate significant difference in BLA (F(1, 38) = 0.067, p = .797, η2 = 0.002).ConclusionsAcupuncture can promote the increase of MEP amplitude, shorten MEP latency, and restore heart rate. Preliminary findings provide novel insights for individuals with exercise habits to alleviate fatigue and enhance sports performance.
DNA Molecular Glue Assisted Bacterial Conjugative Transfer
Authors: Qi Liqing , Wang Wenxi , Fang Le , Li Jin , Qi Lubin , Wang Dachi , Liu Jie , Xiao Yating , Zhou Wei , Fang Xiaohong 
Published: June 2024

AbstractBacterial conjugation, a commonly used method to horizontally transfer functional genes from donor to recipient strains, plays an important role in the genetic manipulation of bacteria for basic research and industrial production. Successful conjugation depends on the donor‐recipient cell recognition and a tight mating junction formation. However, the efficiency of conjugative transfer is usually very low. In this work, we developed a new technique that employed DNA molecule “glue” to increase the match frequency and the interaction stability between the donor and recipient cells. We used two E. coli strains, ETZ and BL21, as a model system, and modified them with the complementary ssDNA oligonucleotides by click chemistry. The conjugation efficiency of the modified bacteria was improved more than 4 times from 10 %–46 %. This technique is simple and generalizable as it only relies on the active amino groups on the bacterial surface. It is expected to have broad applications in constructing engineered bacteria.
Neighborhood ethnicity is related to mammal occupancy and activity across a desert metropolitan area
Authors: Cocroft Alexandreana , Lewis Jesse S. , Clark Jeffrey , Haight Jeffrey , Lerman Susannah B. , Snyder Zachary , Hall Sharon J. 
Published: June 2024

AbstractCities support abundant human and wildlife populations that are shaped indirectly and directly by human decisions, often resulting in unequal access to environmental services and accessible open spaces. Urban land cover drives biodiversity patterns across metropolitan areas, but at smaller scales that matter to local residents, neighborhood socio‐cultural factors can influence the presence and abundance of wildlife. Neighborhood income is associated with plant and animal diversity in some cities, but the influence of other social variables is less well understood, especially across desert ecosystems. We explored wildlife distribution across gradients of neighborhood ethnicity in addition to income and landscape characteristics within residential areas of metropolitan Phoenix, Arizona, USA. Utilizing data from 38 wildlife cameras deployed in public parks and undeveloped open spaces within or near suburban neighborhoods, we estimated occupancy and activity patterns of common mammal species, including species native to the Sonoran Desert (coyote [Canis latrans] and desert cottontail rabbit [Sylvilagus audubonii]), and non‐native domestic cat (Felis catus). Neighborhood ethnicity (percentage of Latino residents) appeared to exhibit a negative relationship with occupancy for coyotes and cottontail rabbits. Additionally, daily activity patterns of coyotes occurred later in the evenings and mornings in neighborhoods with higher proportions of Latino residents, but activity was unaffected by differences in neighborhood income. This study is one of the first to show that social‐ecological mechanisms associated with patterns of neighborhood ethnicity as well as income may help to shape wildlife distribution in cities. These findings have implications for equitable management and provisioning of ecosystem services for urban residents and highlight the importance of considering a range of social covariates to better understand biodiversity outcomes in urban and urbanizing areas.
14‐3‐3σ/Stratifin and p21 limit AKT‐related malignant progression in skin carcinogenesis following MDM2‐associated p53 loss
Authors: McMenemy Carol M. , Guo Dajiang , Quinn Jean A. , Greenhalgh David A. 
Published: June 2024

AbstractTo study mechanisms driving/inhibiting skin carcinogenesis, stage‐specific expression of 14‐3‐3σ (Stratifin) was analyzed in skin carcinogenesis driven by activated rasHa/fos expression (HK1.ras/fos) and ablation of PTEN‐mediated AKT regulation (K14.creP/Δ5PTENflx/flx). Consistent with 14‐3‐3σ roles in epidermal differentiation, HK1.ras hyperplasia and papillomas displayed elevated 14‐3‐3σ expression in supra‐basal keratinocytes, paralleled by supra‐basal p‐MDM2166 activation and sporadic p‐AKT473 expression. In bi‐genic HK1.fos/Δ5PTENflx/flx hyperplasia, basal‐layer 14‐3‐3σ expression appeared, and alongside p53/p21, was associated with keratinocyte differentiation and keratoacanthoma etiology. Tri‐genic HK1.ras/fos‐Δ5PTENflx/flx hyperplasia/papillomas initially displayed increased basal‐layer 14‐3‐3σ, suggesting attempts to maintain supra‐basal p‐MDM2166 and protect basal‐layer p53. However, HK1.ras/fos‐Δ5PTENflx/flx papillomas exhibited increasing basal‐layer p‐MDM2166 activation that reduced p53, which coincided with malignant conversion. Despite p53 loss, 14‐3‐3σ expression persisted in well‐differentiated squamous cell carcinomas (wdSCCs) and alongside elevated p21, limited malignant progression via inhibiting p‐AKT1473 expression; until 14‐3‐3σ/p21 loss facilitated progression to aggressive SCC exhibiting uniform p‐AKT1473. Analysis of TPA‐promoted HK1.ras‐Δ5PTENflx/flx mouse skin, demonstrated early loss of 14‐3‐3σ/p53/p21 in hyperplasia and papillomas, with increased p‐MDM2166/p‐AKT1473 that resulted in rapid malignant conversion and progression to poorly differentiated SCC. In 2D/3D cultures, membranous 14‐3‐3σ expression observed in normal HaCaT and SP1ras61 papilloma keratinocytes was unexpectedly detected in malignant T52ras61/v‐fos SCC cells cultured in monolayers, but not invasive 3D‐cells. Collectively, these data suggest 14‐3‐3σ/Stratifin exerts suppressive roles in papillomatogenesis via MDM2/p53‐dependent mechanisms; while persistent p53‐independent expression in early wdSCC may involve p21‐mediated AKT1 inhibition to limit malignant progression.
Thermodynamic variational principle, its connections to the phenomenological laws and its applications to the derivation of microstructural models
Authors: Du Qiang 
Published: June 2024

AbstractUnderstanding microstructural evolution occupies a central position in the discipline of materials science and engineering. As stated by Carter et al., microstructural evolution involves complex, coupled, and often nonlinear processes even the description of the dynamics for isolated microstructural evolution processes can be quite complicated. It would be desirable to enrich the microstructural evolution theory by introducing a powerful mathematical tool, which could enable describing and predicting the rich intertwining phenomena such as diffusive or displacive phase transformation, grain growth, generation, or annihilation of defects (vacancy, dislocations, etc.) in a straightforward manner. There have been continuing efforts along this front, and I will restrict myself to the issues in the development and application of the thermodynamic variational principle. Although being reviewed by various authors recently, we hope to redraw attentions to some valuable papers and provide our understanding and viewpoints. It is our opinion that the most appealing feature about the principle is the nature that it could give approximate solutions with tunable accuracy. The other feature is its role as a basic principle in deriving the new models. It is hoped that this paper could promote the development and application of the variational principle even further in materials science.
Modification of a commercial fish feeder for use in small rearing ponds
Authors: Stromberg Mark , Barnes Michael E. 
Published: June 2024

Abstract

Objective
Automatic feeders are commonly used in aquaculture, but the feed delivery pattern cannot be adjusted to accommodate a variety of rearing unit sizes. For those few feeders that can be adjusted, their use has been limited because of initial costs, availability, and other issues. This paper describes modification to a commercially available fish feeder (Texas Hunter Products 31.75-kg [70-lb] Lake and Pond Directional Fish Feeder) to effectively provide feed to different-sized ponds.

Methods
This feeder has a 14-m fish feed distribution pattern, making it unusable for smaller ponds. To reduce the distance of fish feed projected from the feeder, a resistor (rheostat) was installed in series with the fan motor.

Result
The rheostat reduced the power to the fan motor, thereby decreasing the feed projection distance. In addition, because the rheostat was adjustable, the resistance—and the resulting power to the fan motor—could be easily changed, making it possible for the same feeder to be used in different-sized ponds while using approximately the same amount of power from the battery and solar panels.

Conclusion
This modification was inexpensive and relatively easy to perform. The feeders reliably dispensed feed in a number of small ponds during an 8-month evaluation period.
Finite‐time L1 bumpless transfer control for switched positive delayed systems: A state‐dependent limited frequency switching scheme
Authors: Wang Peng , Lin Pin , Zhang Hehong , Zhao Ying , Sang Hong , Dimirovski Georgi M. 
Published: June 2024

AbstractThis work is concerned with the bumpless transfer control issue for switched positive delayed systems on finite horizons. A bumpless transfer input scheme and a state‐dependent limited frequency switching scheme, induced by the transient control input discontinuities during controller switching and by the frequent switching for multiple subsystems, respectively, are jointly introduced. The main advantages of the presented schemes are that the amplitude of the control input discontinuities and the frequent switches are all reduced by the dual design of bumpless transfer controllers for subsystems and a state‐dependent limited frequency switching scheme. By utilizing the multiple linear copositive Lyapunov functionals, sufficient conditions are also offered so as to achieve the desirable closed‐loop performances, including positivity, finite‐time boundedness, bumpless transfer property and a prescribed ‐gain property. Finally, a practical example is borrowed which validates the proposed schemes.
On the evaluation of the Ray-Singer torsion path integral
Authors: Blau Matthias , Kakona Mbambu , Thompson George 
Published: June 2024

Abstract
There are very few explicit evaluations of path integrals for topological gauge theories in more than 3 dimensions. Here we provide such a calculation for the path integral representation of the Ray-Singer Torsion of a flat connection on a vector bundle on base manifolds that are themselves S1 bundles of any dimension. The calculation relies on a suitable algebraic choice of gauge which leads to a convenient factorisation of the path integral into horizontal and vertical parts.
Verhaltenstherapeutische Diagnostik und Therapie bei Kopfschmerzerkrankungen
Authors: Klan Timo , Diezemann-Prößdorf Anke , Guth Anna-Lena , Liesering-Latta Eva , Dresler Thomas 
Published: June 2024

ZusammenfassungKopfschmerzerkrankungen (die auch die Gesichtsschmerzen umfassen) sind vielfältig und häufig. Es besteht eine hohe Krankheitslast, dennoch sind Kopfschmerzerkrankungen unterdiagnostiziert und unterversorgt. Kopfschmerzen sollten vor dem Hintergrund des biopsychosozialen Modells gesehen werden. Für die psychologische Diagnostik existieren spezifische Fragebogen, die eine gezielte Behandlungsplanung und -evaluation ermöglichen. Zur psychologischen Behandlung stehen sowohl transdiagnostische als auch kopfschmerzspezifische Interventionen zur Verfügung; diese sollten auf die jeweilige Kopfschmerzerkrankung abgestimmt werden. Psychologische Interventionen können sowohl die Kopfschmerzaktivität als auch die kopfschmerzassoziierte Beeinträchtigung und psychische Belastung reduzieren. Es besteht ein großer Forschungsbedarf zur Optimierung und zur Evaluation psychologisch-psychotherapeutischer Interventionen.
Extending ConWIP by flexible capacity and WIP-Cap adjustment for a make-to-order multi-item multi-stage production system
Authors: Bokor Balwin , Altendorfer Klaus 
Published: June 2024

AbstractConstant-Work-In-Process (ConWIP) is a promising production planning and control method for make-to-order production systems, exhibiting notable potential in attaining reduced tardiness alongside effective management of work in process and finished goods inventories, as demonstrated in various studies. Furthermore, several papers show that the negative effects of high demand uncertainty, which occur when applying a make-to-order approach, can be mitigated by providing flexible capacity to coordinate demand and throughput. Therefore, in this paper the workload-based ConWIP method is combined with a flexible capacity setting method, to enable a better fit between demand and throughput. To fully capitalize on the benefits of flexible capacity and enable the production system to adapt to changes in throughput potential, an adjustment of the WIP-Cap is integrated to avoid machine starvation or unused overcapacity. To evaluate the system performance, a multi-stage multi-item make-to-order flow shop production system with stochastic demand, processing and customer required lead times is simulated. The results of a broad numerical study show a high improvement potential of the extended ConWIP version in comparison to workload-based ConWIP.