bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transfemoral‐only transcatheter aortic valve replacement: A single center experience of 400 consecutive patients
Authors: Moccetti Federico , Wolfrum Mathias , Bossard Matthias , Attinger‐Toller Adrian , Loretz Lucca , Cuculi Florim , Toggweiler Stefan 
Published: May 2024

AbstractBackgroundIn transcatheter aortic valve replacement (TAVR), transfemoral (TF) access offers several advantages over alternative access routes. Advances in sheaths and valve delivery technology have catalyzed the feasibility of TF‐TAVR, even in challenging anatomies.AimsReport procedural characteristics and outcomes of a TAVR program aiming for a 100% TF access rate.MethodsConsecutive patients undergoing TAVR were enrolled in a prospective registry. Equipment used to facilitate TF‐access in challenging anatomies included low‐profile sheaths, dilatators, peripheral balloons, covered and uncovered self‐expanding and balloon‐expandable stents, and intravascular lithotripsy (IVL).ResultsA total of 400 patients with a mean age of 81 ± 6 years (42% female) were analyzed. Minimal iliofemoral artery diameter (MLD) of the main access side was <5 mm in 42 (10.5%), extreme tortuosity was present in 65 (16.3%), and severe calcification in 59 (14.8%). TF‐access was successful in 399 (99.8%) patients. A transaxillary access was used in one patient. In multivariable analysis, an MLD < 5 mm was the strongest predictor for vascular complications (11.9% vs. 3.9%, OR: 3.86, 95% CI: 1.38−10.8, p = 0.01). Such patients also had more major/life‐threatening bleeding (14.2% vs. 3.1%, p < 0.001) and required more planned and unplanned peripheral interventions to enable TF access (35.8% vs. 3.4%, p < 0.001).ConclusionOur study shows that utilization of dedicated sheaths, peripheral balloons, stents, and IVL enables TAVR via TF access in >99% of patients. However, rates of vascular and bleeding complications in patients with narrow iliofemoral arteries (MLD < 5 mm) were high.
A case of post‐renal acute kidney injury caused by bilateral ureterolithiasis
Authors: Morino Junki , Hirai Keiji , Morishita Yoshiyuki 
Published: May 2024

Key Clinical MessageBilateral ureterolithiasis is rare but can cause acute kidney injury (AKI). Clinicians should first examine for post‐renal causes of AKI, even if the patient lacks subjective symptoms.AbstractThis letter describes a case of bilateral ureterolithiasis which presented with post‐renal acute kidney injury (AKI) and was successfully treated by bilateral retrograde ureteric stenting. Clinicians should be aware of post‐renal AKI caused by bilateral ureterolithiasis when acute worsening of renal function with oliguria is observed.
Squamous cell papilloma of the hypopharynx with elongated villous projections
Authors: Suzuki Masami , Yoshida Naohiro , Miura Takaya , Okabe Naota , Hiruta Masahiro 
Published: May 2024

Key Clinical MessageSquamous cell papilloma with elongated villous projections may occur in the hypopharynx and present with symptoms observable on physical examination.
Acute splenic hematoma: A rare complication of snake bite
Authors: Thapa Niranjan , Regmi Shiva K. , Basukala Sunil , Paudel Sandip , Shrestha Oshan , Mehta Bipin , Manoj K. C. , Singh Kaushal K. 
Published: May 2024

Key Clinical MessageSplenic hematoma secondary to snake bite is a potential complication due to snake envenomation and poses a significant risk to the health of the patients. Although relatively rare, this complication once diagnosed, should be initiated with timely anti‐venom administration and supportive care. Clinicians must be aware of any signs of hematological abnormalities in snakebite patients, as the development of splenic hematoma can have serious implications for patient outcomes. Awareness of this potential complication and multidisciplinary collaboration among medical teams are crucial to ensuring effective management and optimal patient care in these clinical scenarios. Understanding this concern can improve patient prognosis and advance the overall approach to snakebite management in healthcare settings.
Bioorthogonal Cycloadditions of C3‐Trifluoromethylated 1,2,4‐Triazines with trans‐Cyclooctenes
Authors: Šlachtová Veronika , Motornov Vladimir , Beier Petr , Vrabel Milan 
Published: May 2024

Abstract1,2,4‐triazines are a valuable class of heterodienes that can be employed in inverse electron‐demand Diels–Alder reactions. However, their broader application in bioorthogonal chemistry is limited due to their low reactivity. This article focuses on 3‐(trifluoromethyl)‐1,2,4‐triazines, which can be efficiently prepared in a one‐pot reaction from NH‐1,2,3‐triazoles. These triazines are highly reactive in reactions with strained cyclooctenes, giving second‐order rate constants as high as 230 M−1 s−1. Despite their high reactivity, the compounds remain sufficiently stable under biologically relevant conditions. We show that some of the compounds are fluorogenic, a property of potential use in bioimaging. In addition, we demonstrate the successful application of the triazines in labeling model biomolecules. Our work shows that the reactivity of 1,2,4‐triazines can be enhanced by the 3‐CF3‐substitution, which we consider an important step toward the wider use of this promising class of reagents.
Influence of Chemical Modifications of the Crystallophore on Protein Nucleating Properties and Supramolecular Interactions Network
Authors: Roux Amandine , Alsalman Zaynab , Jiang Tao , Mulatier Jean‐Christophe , Pitrat Delphine , Dumont Elise , Riobé François , Gillet Natacha , Girard Eric , Maury Olivier 
Published: May 2024

AbstractCrystallophores are lanthanide complexes that have demonstrated outstanding induction of crystallization for various proteins. This article explores the effect of tailored modifications of the crystallophore first generation and their impact on the nucleating properties and protein crystal structures. Through high‐throughput crystallization experiments and dataset analysis, we evaluated the effectiveness of these variants, in comparison to the first crystallophore generation G1. In particular, the V1 variant, featuring a propanol pendant arm, demonstrated the ability to produce new crystallization conditions for the proteins tested (hen‐egg white lysozyme, proteinase K and thaumatin). Structural analysis performed in the case of hen egg‐white lysozyme along with Molecular Dynamics simulations, highlights V1′s unique behavior, taking advantage of the flexibility of its propanol arm to explore different protein surfaces and form versatile supramolecular interactions.
Revealing the Mechanistic Features of an Electrosynthetic Catalytic Reaction and the Role of Redox Mediators through DFT Calculations and Microkinetic Modeling
Authors: Díaz‐Ruiz Marina , Nieto‐Rodríguez Marc , Maseras Feliu 
Published: May 2024

AbstractOrganic electrosynthesis is an emerging field that provides original selectivity while adding features of atom economy, sustainability, and selectivity. Electrosynthesis is often enhanced by redox mediators or electroauxiliaries. The mechanistic understanding of organic electrosynthesis is however often limited by the low lifetime of intermediates and its difficult detection. In this work, we report a computational analysis of the mechanism of an appealing reaction previously reported by Mei and co‐workers which is catalyzed by copper and employs iodide as redox mediator. Our scheme combines DFT calculations with microkinetic modeling and covers both the reaction in solution and the electrodic steps. A detailed mechanistic scheme is obtained which reproduces well experimental data and opens perspectives for the general treatment of these processes.
A century of statistical Ecology
Authors: Gilbert Neil A. , Amaral Bruna R. , Smith Olivia M. , Williams Peter J. , Ceyzyk Sydney , Ayebare Samuel , Davis Kayla L. , Leuenberger Wendy , Doser Jeffrey W. , Zipkin Elise F. 
Published: May 2024

AbstractAs data and computing power have surged in recent decades, statistical modeling has become an important tool for understanding ecological patterns and processes. Statistical modeling in ecology faces two major challenges. First, ecological data may not conform to traditional methods, and second, professional ecologists often do not receive extensive statistical training. In response to these challenges, the journal Ecology has published many innovative statistical ecology papers that introduced novel modeling methods and provided accessible guides to statistical best practices. In this paper, we reflect on Ecology's history and its role in the emergence of the subdiscipline of statistical ecology, which we define as the study of ecological systems using mathematical equations, probability, and empirical data. We showcase 36 influential statistical ecology papers that have been published in Ecology over the last century and, in so doing, comment on the evolution of the field. As data and computing power continue to increase, we anticipate continued growth in statistical ecology to tackle complex analyses and an expanding role for Ecology to publish innovative and influential papers, advancing the discipline and guiding practicing ecologists.
Improvement of both human and animal memory by synergy between fructooligosaccharide and L‐theanine function establishing a safe and effective food supplement
Authors: Li Yuan , Jiang Yuying , Zhang Zubing , Loake Verity I. P. , Bao Xu , Loake Gary J. 
Published: May 2024

AbstractAging is classically associated with a decline of cognitive abilities, especially in relation to memory. While the development of potential treatments for neurodegenerative diseases has been in sharp focus, mild cognitive impairment (MCI), a form of age‐related memory loss, in the absence of severe functional impairment, a condition experienced by many healthy adults, has received relatively little attention. Advances in this space would make significant contributions to the goal of healthy aging and may also help promote cognitive performance across the wider population. The individual action of either fructooligosaccharide (FOS) or L‐theanine, both natural plant‐derived molecules, has been tentatively linked with improvements in cognition, but our understanding remains far from complete. We therefore determined the effect of different dose combinations of FOS and L‐theanine (termed MT‐01/GBL‐Memory1) in mice against FOS and L‐theanine monotherapy. FOS and L‐theanine were found to synergistically enhance murine memory in our animal tests at a dose of 100 mg/kg (coefficient of drug interaction (CDI) < 1). In a subsequent human trial, we demonstrated that MT‐01 improved the memory of healthy adults after 1 month of consumption. Our results suggest that a combination of FOS and L‐theanine synergistically enhances murine memory within a specific dose range. We show that this plant natural product regimen also improves human memory in a population of healthy adults. MT‐01 therefore represents a novel, safe, and effective dietary supplement to promote human memory and cognition.
The association between energy‐adjusted dietary inflammatory index and 10‐year cardiovascular risk: Fasa adult cohort study
Authors: Sepehrinia Matin , Pourmontaseri Hossein , Naghizadeh Mohammad Mehdi , Vahid Farhad , Hebert James R. , Homayounfar Reza , Alkamel Abdulhakim 
Published: May 2024

AbstractA healthy diet is dominant in cardiovascular disease (CVD) prevention. Inflammation is pivotal for CVD development. This study aimed to evaluate the association between the pro‐inflammatory diet and the CVD risk. This cross‐sectional study involved 10,138 Fasa adult cohort study participants. After excluding participants with missing data, the Energy‐Adjusted Dietary Inflammatory Index (E‐DII) was calculated to assess the inflammatory potential of diet using the recorded Food Frequency Questionnaire. Framingham risk score (FRS) was used to predict the 10‐year risk of CVD. The association between E‐DII and high risk for CVD was investigated using multinominal regression. After exclusion, the mean age of studied individuals (n = 10,030) was 48.6 ± 9.6 years, including 4522 men. Most participants were low risk (FRS <10%) for CVD (87.6%), while 2.7% of them were high risk (FRS ≥20%). The median FRS was 2.80 (1.70, 6.30). The E‐DII ranged from −4.22 to 4.49 (mean E‐DII = 0.880 ± 1.127). E‐DII was significantly associated with FRS. This result persisted after adjusting for confounding factors and in both genders. This study revealed that the pro‐inflammatory diet significantly increases the CVD risk. Consequently, reducing the inflammatory potential of diet should be considered an effective dietary intervention in CVD prevention.
The effect of synbiotic coating of flaxseed mucilage‐defatted rice bran carbohydrate on quality of dried mango, viability of Bifidobacterium animalis subsp. LactisBB12 on storage and simulating gastrointestinal condition
Authors: Didar Zohreh , Soltan‐Dallal Mohammad Mehdi , Goharjoo Behzad 
Published: May 2024

AbstractIn the present study, a synbiotic coating of flaxseed mucilage, defatted rice bran carbohydrate, and Bifidobacterium animalis subsp. Lactis BB12 was fabricated for coating dried mango slices (M‐P‐C). The control samples contained only probiotic bacteria without coating (M‐P). Several quality parameters (moisture, weight loss, shrinkage percentage, pH, firmness, and color) were assessed on specific storage circumstances (25°C, relative humidity (RH) = 22%.). In addition, the survival of Bifidobacterium animalis subsp. Lactis BB12 was evaluated on storage and under simulated gastrointestinal (GI) conditions. According to the results, the log number of Bifidobacterium animalis subsp. Lactis BB12 reached 8.1 and 6.2 for coated and uncoated samples, respectively, during the 45 days storage at 25°C (>6 log CFU (log colony‐forming units)/g) and at finished stage of in vitro gastrointestinal circumstances, the log number of probiotic bacterial count reached 6.8 and 4 for coated and uncoated samples, respectively. The coating resulted in significantly less weight loss, moisture loss, and shrinkage of the mango slices than uncoated ones (p < .05). The growth of yeasts and molds was undetectable in both samples. The results of acceptance experiments for M‐P and M‐P‐C dried mango samples showedthat there were no significant differences between M‐P and M‐P‐C samples (p  >.05), indeed in the case of purchase intention and overall acceptability. After reading the text highlighting, there was no significant difference in all attributes of M‐P‐C samples pre and post of reading text highlighting. It could be concluded that the synbiotic coating of mango slices improved the quality characteristics of the dried mango as well as viability of the probiotic bacteria at storage time and under simulated gastrointestinal conditions.
Characterizing the antioxidant and antifungal properties of nano‐encapsulated pistachio hull extract in fenugreek seed gum to maintain the quality and safety of fresh pistachio
Authors: Fatemi Ali , Najafi Ali , Razavi Razie , Jafarzadeh Shima 
Published: May 2024

AbstractThe quality of pistachio, one of the export products of Iran, will be decreased during storage as a result of mold spoilage, toxins production, and oil oxidation. This study aimed to investigate the capability of pistachio hull extract (PHE) loaded in fenugreek seed gum (FSG):whey protein isolate (WPI) nanoemulsion to control oil oxidation, and fungi growth in fresh pistachio nut during storage at 4°C. The total anthocyanin and total phenolic content of the PHE were 125.44 μg/g and 675.18 mg/g, respectively. The DPPH radical scavenging activity of PHE at 100 ppm was higher than that of tert‐butylhydroquinon (TBHQ). In comparison with other concentrations, 50 ppm showed the strongest antifungal activity against Aspergillus flavus, Aspergillus parasiticus, and Aspergillus nomius. All nanoemulsions have a mean size lower than 265 nm. The polydispersity index (PDI) of different nanoemulsions was lower than 0.3, and a negative zeta potential was observed. The encapsulation efficiency was higher than 67.0% and all nanoemulsions had spherical morphology. The pistachio nuts were coated with different coating solutions containing 0 and 100 ppm of PHE and stored at 4°C for 8 weeks. The results showed that the pistachio sample coated with a composite coating of WPI and FSG containing 100 ppm of PHE has a higher moisture content and lower changes in L*, a*, and b* indexes, oil oxidation, fungi development, and total mold and yeast count. This treatment exhibited higher overall acceptance than other samples at the end of storage time. The results of this study suggest the use of biodegradable coatings enriched with natural extracts that have high antioxidant and antifungal activities.
Factors for predicting 28‐day mortality in older patients with suspected of having sepsis in the emergency department
Authors: Sanguanwit Pitsucha , Yuksen Chaiyaporn , Khorana Jiraporn , Phootothum Yuranun , Damdin Siriporn , Sutham Krongkarn 
Published: May 2024

AbstractBackgroundOlder patients face increased sepsis risk, requiring precise prognostic tools in the emergency department (ED). This study aimed to explore factors predicting 28‐day mortality among older (≥60 years) patients with suspicion of sepsis in the ED.MethodsWe performed a retrospective cohort study. Data for all older patients with clinical suspected sepsis presenting to the ED from 1 October 2018 to 31 December 2018, were collected. Prognostic factors, characteristics, comorbidities, vital signs at triage, the emergency severity score, initial laboratory results, and sepsis bundle treatment were analyzed using univariable and multivariable Cox regression. Hazard ratios (HR) were calculated using these analytical methodologies to prognosticate 28‐day mortality.ResultsA total of 329 older patients with suspected sepsis were included. The overall 28‐day mortality was 10.33%. Independent prognostic factors that were significantly associated with 28‐day mortality were malignancy (adjusted hazard ratio [aHR]: 3.67; 95% confidence interval [CI]: 1.90, 7.09; p < 0.01), oxygen saturation ≤93% (aHR: 3.37; 95% CI: 1.79, 3.43; p < 0.01), and dependent status (hazard ratio [HR]: 2.27; 95% CI: 1.14, 4.53; p = 0.02).ConclusionsThis study suggests that “MOD”; M‐Malignancy, O‐Oxygen saturation ≤93%, and D‐Dependent status are significant prognostic indicators for 28‐day mortality among older patients with suspected sepsis in the ED.Trial registrationThe trial was retrospectively registered in the Thai Clinical Trial Registry on 06/05/2022, identification number TCTR20220506006.
Responses of soil moisture at different topographic positions to rainfall events along a steep subtropical forested hillslope
Authors: Lu Shiguo , Liu Muxing , Yi Jun , Zhang Hailin , Wan Jinhong 
Published: May 2024

AbstractUnderstanding the dynamic response of soil moisture to rainfall is crucial for describing hydrological processes at the hillslope scale. However, because of sparse monitoring coupled with the complexity of water movement and steep topography, the findings of rainfall‐related soil moisture dynamics have not always been consistent, indicating a need for systematic investigations of soil moisture dynamics and infiltration patterns following rainfall inputs at multiple topographic positions along a hillslope. This study aimed to examine the nature of these responses by characterizing and quantifying the response amplitude, rate and time for 37 large rainfall events at 25 combinations of topographic positions and soil depths along a steep forested hillslope. Our results showed that soil moisture responses under different rainfall patterns could be attributed to one or the other rainfall characteristics, such as rainfall intensity and amount. However, soil moisture dynamics at different hillslope positions after rainfall varied widely due to the controls of soil properties, topography, and non‐equilibrium flow. Preferential flow was more evident under dry initial soil conditions than under wet initial soil conditions. Findings of this study reveal that the dynamic response patterns of soil moisture to rainfall do not always follow topographic controls, which can improve our understanding of water cycling related to the infiltration process at the hillslope scale, and support water resources management in subtropical mountain ecosystems.
High performance of the DNA methylation‐based WID‐qEC test for detecting uterine cancers independent of sampling modalities
Authors: Illah Ojone , Scott Malcolm , Redl Elisa , Barrett James E. , Schreiberhuber Lena , Herzog Chiara , Vavourakis Charlotte D. , Jones Allison , Evans Iona , Reisel Dan , Chandrasekaran Dhivya , Doufekas Kostas , Graham Radha , Kotsopoulos Ioannis C. , MacDonald Nicola , Arora Rupali , Olaitan Adeola , Rosenthal Adam , Widschwendter Martin 
Published: May 2024

AbstractEndometrial cancer (EC) is the most prevalent gynaecological cancer in high‐income countries and its incidence is continuing to rise sharply. Simple and objective tools to reliably detect women with EC are urgently needed. We recently developed and validated the DNA methylation (DNAme)‐based women's cancer risk identification—quantitative polymerase chain reaction test for endometrial cancer (WID‐qEC) test that could address this need. Here, we demonstrate that the stability of the WID‐qEC test remains consistent regardless of: (i) the cervicovaginal collection device and sample media used (Cervex brush and PreservCyt or FLOQSwab and eNAT), (ii) the collector of the specimen (gynaecologist‐ or patient‐based), and (iii) the precise sampling site (cervical, cervicovaginal and vaginal). Furthermore, we demonstrate sample stability in eNAT medium for 7 days at room temperature, greatly facilitating the implementation of the test into diagnostic laboratory workflows. When applying FLOQSwabs (Copan) in combination with the eNAT (Copan) sample collection media, the sensitivity and specificity of the WID‐qEC test to detect uterine (i.e., endometrial and cervical) cancers in gynaecologist‐taken samples was 92.9% (95% confidence interval [CI] = 75.0%–98.8%) and 98.6% (95% CI = 91.7%–99.9%), respectively, whilst the sensitivity and specificity in patient collected self‐samples was 75.0% (95% CI = 47.4%–91.7%) and 100.0% (95% CI = 93.9%–100.0%), respectively. Taken together these data confirm the robustness and clinical potential of the WID‐qEC test.
Impact of body mass index on sonographic measurement of head perineum distance before operative vaginal delivery
Authors: Sanchez Maëva , Berveiller Paul , Behal Hélène , Tursack Anaïs , Plurien Alix , Ghesquière Louise , Garabedian Charles 
Published: May 2024

AbstractObjectiveTo evaluate the impact of body mass index (BMI) on sonographic measurement of head perineum distance (HPD) before operative vaginal delivery (OVD).MethodsThis was a single‐center retrospective cohort study (Lille, France) conducted from March 1, 2019 to October 31, 2020 including all singleton and OVD. HPD measurement was systematically performed without and with compression on the perineum soft tissues. The level of station was defined by vaginal examination and three maternal BMI groups were defined (normal BMI [<24.9 kg/m2] vs overweight [25–29.9 kg/m2] vs obese [≥30 kg/m2]). HPD measures were compared between BMI groups and compression, in distinct level of station, using a two‐factor analysis of variance including BMI groups, the compression, and the interaction term BMI group compression.ResultsA total of 775 women were included: 488 with normal BMI, 181 overweight patients and 106 obese patients. The measurement of HPD before OVD without and with compression on the soft tissues was significantly different between the BMI groups only in the lower part, particularly between normal BMI and obese patients (mean difference (95% CI): 6.6 mm (4.0 to 9.2) without compression; 3.8 (1.1 to 6.4) with compression).ConclusionThe values of HPD without and with compression on the soft tissues on the maternal perineum were different according to the maternal BMI concerning lower part station. Thus, it seems important to define thresholds of HPD measures corresponding to each head station levels according to maternal BMI.