bluuebunny/crossref_metadata_2025_split huggingface dataset:
ОРГАНИЗАЦИЯ ПУБЛИЧНЫХ КОММУНИКАЦИЙ В ПРОЦЕССЕ КОНСОЛИДАЦИИ РЕГИОНАЛЬНОГО СООБЩЕСТВА В ПРИГРАНИЧНЫХ РЕГИОНАХ РОССИИ
Authors: Бабинцев Валентин Павлович , Серкина Яна Игоревна 
Published: June 2024

Цель исследования: рассмотреть особенности организации публичных коммуникаций в консолидирующихся сообществах приграничных с Украиной субъектах РФ.
Методологическую базу исследования представляют варианты позиционирования коммуникаций в зависимости от избранных моделей консолидации: стихийной, кризисной, имитационной, административной, утопической и партнерской.
Результаты исследования. Доказывается, что в настоящее время наиболее перспективной является партнерская модель, в рамках которой возможно построение сбалансированной системы конструктивных коммуникаций, предполагающей их институционализацию. Формулируются принципы формирования такой системы и даются рекомендации по их реализации.
Перспективы исследования заключаются в обеспечении развития процесса консолидации региональных сообществ в приграничных регионах России в условиях нестабильной социальной среды.
СОВРЕМЕННАЯ КОНЦЕПЦИЯ ФОРМИРОВАНИЯ ДОВЕРИЯ В СОЦИУМЕ
Authors: Литвина Кристина Яковлевна 
Published: June 2024

Целью исследования является оценка современной концепции формирования доверия в российском обществе как фактора стабильного развития государства.
Методологическую базу исследования представляют основные положения о концепции формирования доверительных отношений в социуме. Основными научные методы: методы обобщения, систематизации, сравнения и статистического анализа.
Результаты исследования. В рамках статьи рассмотрены взгляды на концепцию формирования доверия в социуме. В теоретическом обзоре рассмотрена сущность феномена доверия в социальном управлении. Были исследованы статистические данные об уровне доверия граждан к российской власти. На основе результатов были выявлены основные особенности формирования доверия в российском социуме. Был проведен сопоставительный анализ эмпирических данных с другими странами. В статье сделан акцент на роли государства в формировании концепции доверия. Общество и государство выступают в качестве субъектов доверительных отношений. Необходимо разграничивать традиционный и современные подходы к специфике формирования доверия. В настоящий момент концепция доверия в социуме строится на социально-политическом взаимодействии, которое помимо линейных, включает в себя нелинейные компоненты, а именно — взаимодействие субъектов через цифровые технологии без учета авторитета данного субъекта в системе общественных отношений.
Comparative analysis of the profile of circulating microRNAs in the blood plasma of patients with gliomas
Authors: Gvaldin D. Yu. , Petrusenko N. A. , Rostorguev E. E. , Dimitriadi S. N. , Kavitskiy S. E. , Timoshkina N. N. 
Published: June 2024

Against the background of modest successes in the development of new diagnostic and therapeutic tools to improve the survival of patients with glial brain tumors, early diagnosis of this pathology remains relevant. Endogenous noncoding miRNAs that regulate the expression of target mRNAs have become attractive targets for the development of circulating biomarker-based assays, because sample acquisition does not require invasive sampling such as biopsy.Purpose of the study. To determine the levels of circulating microRNAs in the blood plasma of patients with glial tumors, meningiomas and apparently healthy donors, using high-output sequencing.Material and methods. 26 blood plasma samples were selected from the biobank data base of the National Medical Research Center for Oncology, and the total RNA was studied using the NGS sequencing method. The sample included: 2 cases of oligodendroglioma (grades 2–3), 6 – astrocytomas of 2–4 degrees of malignancy, 7 – glioblastomas of 4 degrees of malignancy, 7 – benign neoplasms (meningiomas), 4 – control (conditionally healthy donors).Results. During the primary analysis, a pool of 71 differentially expressed microRNAs was identified, the expression of which was tumor-specific: 20 microRNAs for glioblastoma, 4 microRNAs for astrocytoma, 23 microRNAs for oligodendroglioma, 24 microRNAs for meningioma. At the same time, 47 microRNAs showed increased levels in the blood plasma compared to the control group, 15 showed a corresponding decrease in levels. A comparative analysis identified microRNAs that specifically differentiate each tumor type.Conclusion. The results obtained seem promising and set the vector for further research, which will include expanding the sample and validating the identified biomarkers to determine their diagnostic value.
Individualized Surgeon Reports in a Statewide Registry
Authors: Mesko J. Wesley , Zheng Huiyong , Hughes Richard E. , Hallstrom Brian R. 
Published: June 2024

Abstract:
Despite progress with the development of joint replacement registries in the United States, surgeons may have limited opportunities to determine the cumulative outcome of their own patients or understand how those outcomes compare with their peers; this information is important for quality improvement. In order to provide surgeons with accurate data, it is first necessary to have a registry with complete coverage and patient matching. Some international registries have accomplished this. Building on a comprehensive statewide registry in the United States, a surgeon-specific report has been developed to provide surgeons with survivorship and complication data, which allows comparisons with other surgeons in the state. This article describes funnel plots, cumulative sum reports, complication-specific data, and patient-reported outcome measure data, which are provided to hip and knee arthroplasty surgeons with the goal of improving quality, decreasing variability in the delivery of care, and leading to improved value and outcomes for hip and knee arthroplasty in the state of Michigan.
Measurement and spectral analysis of medical shock wave parameters based on flexible PVDF sensors
Authors: Xu Liansheng , SHEN Fei , FAN Fan , WU Qiong , WANG Li , LI Fengji , FAN Yubo , NIU Haijun 
Published: June 2024

Abstract

Extracorporeal shock wave therapy (ESWT) achieves its therapeutic purpose mainly through the biological effects produced by the interaction of shock waves with tissues, and the accurate measurement and calculation of the mechanical parameters of shock waves in tissues are of great significance in formulating the therapeutic strategy and evaluating the therapeutic effect. This study utilizes the approach of implanting flexible polyvinylidene fluoride (PVDF) vibration sensors inside the tissue-mimicking phantom of various thicknesses to capture waveforms at different depths during the impact process in real time. Parameters including positive and negative pressure changes (P+, P−), pulse wave rise time (\({t}_{r}\)), and energy flux density (EFD) are calculated, and frequency spectrum analysis of the waveforms is conducted. The dynamic response, propagation process, and attenuation law of the shock wave in the phantom under different impact intensities were analyzed. Results showed that flexible PVDF sensors could precisely acquire the characteristics of pulse waveform propagating within the phantom. At the same depth, as the driving pressure increases, P+ and P− increase linearly, and \({t}_{r}\) remains constant. At the same driving pressure, P+, P−, and EFD decay exponentially with increasing propagation depth. At the same depth, the spectra of pulse waveforms are similar, and the increasing driving pressure does not cause significant changes in carrier frequency and modulation frequency. The research findings could provide a reference for developing ESWT devices, improving treatment strategies, and enhancing the safety of clinical applications.
SurgeRy and physiothErapy Versus physIotherapy only for chronic paTellofemorAL paIn: study protocol for a randomiSed controllEd trial (REVITALISE)
Authors: de Ven Myrthe P.F. van , Ophey Martin , de Graaf Victor van , de Groes Sebastiaan A.W. van , Sinkeldam Marijn , Wijers Charlotte W.H. , Koëter Sander 
Published: June 2024

Abstract

Background: Patellofemoral pain (PFP) is a common musculoskeletal disorder resulting in anterior knee pain. Physiotherapy is the current standard treatment, while surgical intervention (tibial tubercle transfer [TTT]) is reserved for chronic cases when nonoperative treatment has failed. However, to date, no randomized controlled trials (RCT) have compared TTT combined with a physiotherapy (PT) program PT to PT alone as the initial treatment for PFP.
Methods: A single-centre RCT in patients with chronic PFP (>1 year) will be randomized to either TTT followed by PT (n=20) or to PT alone (n=20). The primary outcome is knee pain at 18 weeks for the TTT group and at 12 weeks for the PT group, measured by the visual analog scale (VAS). Secondary outcomes include Patient Recorded Outcome Measures (PROMs) using the Kujala score, International Knee Documentation Committee (IKDC) ‘Subjective Knee Form’, Tegner Activity score and EuroQol 5D-5L for quality of life. Range of motion (ROM) is measured using the decline step-down test (DSDT). The difference in direct medical costs will also be assessed.
Discussion: The REVITALISE study is the first randomized study to compare surgical intervention (TTT) followed by PT to PT alone in patients with chronic PFP. This study will generate level-1 evidence on the most effective treatment for chronic PFP, which can be integrated into the national guideline to aid orthopaedic surgeons and physiotherapists in their decision-making and ultimately improve our care for patients with chronic PFP.
Trial registration
Study Identifier NCT06227806, registered on 26 Jan 2024 on ClinicalTrials.gov. The study underwent independent peer review and received approval from the ethical review board (number NL80956.091.22).
Assessment and exploratory analysis of the indicator-based surveillance (IBS) system in Rwanda
Authors: Nizeyimana Pacifique , Nsekuye Olivier , Ruyange Laurent , Twahirwa Solange , Manariyo Marcel , Zimulinda Alain , Kayirangwa Marie Rose , Uwamahoro Sandrine , Itanga Ines , Kabeja Adeline , Rwagasore Edson , Muvunyi Claude Mambo 
Published: June 2024

Abstract

Introduction: Rwanda, like other countries, is facing emerging and re-emerging infectious diseases. Since 2002, Rwanda has implemented indicator-based surveillance through the Integrated Disease Surveillance and Response (IDSR) framework. This study aimed to explore the completeness and timeliness of reporting and use of the tool in Rwanda. Method: In this study, we used a cross-sectional descriptive approach using a structured questionnaire for IDSR focal persons and data managers in 46 public hospitals accompanied by a secondary data analysis of monthly records from the National HMIS for the period of 2018–2021 from 564 public health facilities (HFs) and 283 private HFs. Exploratory analysis and correlation assessments complemented the dataset analysis. Results: This study revealed that public HF consistently achieves or surpasses the 80% completeness (96.7%) and timeliness (80.8%) targets. In contrast, private HF demonstrates 42.8% and 25.3% completeness and timeliness, respectively. Eight-seven percent (87%) of the interviewees reported having received feedback from the central level, with varying frequencies. Hospitals provide feedback to HFs in their catchment area (91%), but the frequencies differ. Regarding the data accuracy, 95.7% of the respondents possessed standard case definitions, and 87% regularly referred to them. Two-thirds (67.6%) reported that they monitored weekly trends, but only 34.9% produced and shared weekly reports promptly. The challenges identified included internet issues (30%), other competing duties (30%), and forgetting to report (26%). A total of 84.8% of HFs used the system to detect outbreaks in their catchment areas; 71.7% of these HFs responded to the system according to national guidelines. Furthermore, 92.3% of all HFs used the eIDSR system for planning purposes. Conclusion: The IDSR system was highly useful because it provided evidence for decision-making in early detection and response to outbreaks as well as for hospital program planning. Maintaining timely reporting, enhancing data quality and timely use, and improving health workers' knowledge and practices are vital for a surveillance system user to detect outbreaks early. More focus should be placed on private health facilities.
Biliary Drainage in Palliative and Curative Intent European Patients with Hilar Cholangiocarcinoma and malignant hilar obstruction: a retrospective single center analysis
Authors: Drews Jan , Baar Lea-Catharina , Schmeisl Theresa , Bunde Torsten , Stang Axel , Reese Tim , Wagner Kim Caroline , Oldhafer Karl Jürgen , Hahn Thomas 
Published: June 2024

Abstract

Background and Aims:
Relief of cholestasis in hilar cholangiocarcinoma is commonly undertaken in both curative and palliative treatment concepts. There are numerous open questions with regard to the ideal biliary drainage strategy – including what constitutes clinical success (CS). In the existing data, curative patients and patients from the Western world are underrepresented.
Patients and Methods:
We performed a retrospective analysis of patients with complex malignant hilar obstruction (Bismuth-Corlette II and higher) due to cholangiocarcinoma who underwent biliary drainage at a German referral center between 2010 and 2020. We aimed to define CS and complication rates and directly compare outcomes in curative and palliative patients.
Results
56 curative and 72 palliative patients underwent biliary drainage. In patients with curative intent, CS was achieved significantly more often regardless of what definition of CS was applied (e.g., total serum bilirubin (TSB) < 2 mg/dl: 66.1% vs. 27.8%, p = < 0.001, > 75% reduction of TSB: 57.1% vs. 29.2%, p = 0.003). This observation held true when only subgroups with the same Bismuth-Corlette stage were compared. Moreover, palliative patients experienced a significantly greater percentage of adverse events (33.3% vs 12.5%, p = 0.01). Curative intent treatment and TSB at presentation were predictive factors of CS regardless of what definition of CS was applied. The observed CS rates are comparable to those published series of curative patients, but inferior to reported CS rates in palliative series mostly from Asia.
Conclusions
Biliary drainage in complex malignant hilar obstruction due to cholangiocarcinoma is more likely to be successful and less likely to cause adverse events in curative patients compared to palliative patients.
RMP limits innate immune activation in macrophages by inhibiting IKKβ activity in sepsis
Authors: Dong Liwei , Pang Shujie , Jiang Tianyi , Wang Naiguo , Cui Xiaowen , Wang Hui , Pan Yufei , Yang Ning 
Published: June 2024

Abstract

Nuclear factor κB activity is a central component of inflammatory and innate immune responses. The inhibition of NF-κB signaling and of the IκB kinase complex is important for understanding the control of innate immunity. Here, we identified RNA polymerase II subunit 5 (RPB5)-mediating protein (RMP) as an inhibitor of the IKK complex, which thus inhibited NF-κB signaling in macrophages. In resting macrophages, RMP directly bound to the kinase domain of IKKβ and inhibited its activity by recruiting protein phosphatase 2A to the IKK complex. When mouse macrophages were treated with lipopolysaccharide, a TLR4 agonist that stimulates NF-κB signaling, RMP was phosphorylated by IKKβ at Ser439 and dissociated from the IKK complex, which further activated NF-κB signaling. Macrophage-specific deletion of Rmp reduced survival in mice due to an increased inflammatory response in experimental models of sepsis. This work demonstrates that RMP inhibits TLR4-induced NF-κB activation and exerts homeostatic control of innate immunity, and may be promising as a therapeutic target in the limiting of NF-κB signaling.
Lower all-cause 30-day mortality during summer following ankle fracture surgery. A Swedish Perioperative Register-based study 2012-2022
Authors: Lundin Elin , Karlsson Jon , Jakobsson Jan 
Published: June 2024

Abstract

Introduction:
Ankle fracture is the third most common fracture with a seasonal-occurrence variation in the Nordic countries. Ankle fractures commonly require surgery and anaesthesia. An important quality-indicator of perioperative-care is the all-cause 30-day mortality. Little is known about early mortality after ankle fracture repair in Sweden and whether there is a seasonal-occurrence variation of the 30-day mortality.
Aim
The aim of the present register-based study was to assess seasonal-variation in all-cause 30-day mortality associated with surgical repair of ankle fractures in Sweden during a 10-year period; 2012–2022 adjusted for age and ASA-class.
Material and Methods
All patients aged ≥ 18 years who underwent ankle fracture surgery and were registered in the Swedish Perioperative Quality Register (SPOR) between 2012 and 2022, with seasonal information, were included in the analysis (n = 31,655). Information on patient characteristics, perioperative observations, and early mortality were collected. Descriptive and regression statistics were applied.
Results
The all-cause 30-day mortality was 0.24%, with significantly lower 30-day mortality during summer (0.09%) compared with autumn (0.32%) and spring (0.28%), (p = 0.026). Patients undergoing ankle fracture surgery were significantly younger and had a significantly higher proportion of low-risk ASA-class during the summer period. The odds ratio of dying within 30-days were still significantly lower during the summer compared with the other seasons, both unadjusted and adjusted for age-, ASA-class, gender, and urgency of procedure. Increased risk for mortality within 30-days was seen among elderly, females, high ASA-class, and emergent surgery.
Conclusions
The all-cause 30-day mortality rate after ankle fracture surgery in Sweden is reassuringly low, with the lowest rate seen during the summer. Advancing age and higher ASA-class were associated with an increasing risk of 30-day mortality.
Gut Microbiota and Metabolomics Correlation in a Mouse Model of Acute-on-Chronic Liver Failure
Authors: Teng xiangnan , Yang Li , Tang Hong , Bai Lang 
Published: June 2024

Abstract

Acute-on-chronic liver failure (ACLF) is a high-mortality syndrome often causing multi-organ failure. Recent studies emphasize the gut-liver axis, showing gut microbiota impacts liver function via bile acid regulation, fatty acid production, and immune modulation. Metabolomics reveals metabolic changes and potential biomarkers. This study explores gut microbiota and metabolic correlations to enhance ACLF diagnosis, treatment, and prognosis. In this study, Established groups included ALF, liver fibrosis (LF), and normal control groups, from which stool, blood, and liver samples were collected. Using 16S rRNA high-throughput sequencing, we analyzed gut microbiota abundance, diversity, community composition, and flora changes, identifying specific microorganisms within the ACLF group. Non-targeted metabolite analysis was conducted using GC/MS and LC/MS to identify differential metabolites in the ACLF group and correlate them with differential microbes. The results revealed no significant change in gut microbial abundance and increased diversity in the ACLF group. Anaplasma phylum, Clostridia_vadinBB60_group, Ali stipes, Marvinbryantia, Lachnoclostridium and Ruminalococcus were significantly enriched in the ACLF group. Among them, Anaplasma sp. differed significantly in all control groups and was highly enriched in the ACLF group. In addition, using Spearman's analysis, Clostridia_vadinBB60_group was positively correlated with taurocholic acid, and was associated with glycerophosphorylcholine (PC) (16:1(9E)/0:0), PC (16:1(9E)/0:0), (±) 12-hydroxy eicosatetraenoic acid (HETE) and lysophosphatidylcholine (LysoPC ) (16:1(9Z)/0:0) were negatively correlated. S. parapsilosis was negatively correlated with taurocholic acid, PC (18:1(17Z)/18:1(17Z)) and L-isoleucine, and positively correlated with PC (20:1(9Z)/0:0) and (±) 12-HETE . In conclusion, we elucidated the increased diversity of the gut microbiota and potential pathogenic microorganisms in ACLF, along with their association with key metabolites. Our study provides crucial insights for a deeper understanding of ACLF pathogenesis and the identification of potential therapeutic targets.
Predict In-Hospital Mortality in COVID-19 Patients with a Machine Learning Webpage Tool Based on Clinical Laboratory Data: An Exploratory Research
Authors: Wang Yang , Zhan Jieyu , Zhang Fan , Cheng Jing , Li Junxun 
Published: June 2024

Abstract

Background
The death risk induced by COVID-19 posed tremendous pressure on medical services, resulting in a shortage of critical care resources and a heavy disease burden. Developing predictive algorithms based on local patient data could be more effective for supporting decisions on the level of healthcare required.
Methods
Laboratory test results of the COVID-19 patients were collected. Five machine learning (ML) approaches were applied to develop a predictive algorithm for in-hospital mortality.
Results
Our cohort enrolled 602 patients with COVID-19 and 40 laboratory tests after data preprocessing. The RF-based model was chosen as the predictive algorithm, namely MOP@COVID. MOP@COVID performed well in the training set and validation set. MOP@COVID yielded a sensitivity of 0.818, a specificity of 0.987, an accuracy of 0.973, and an AUC of 0.958 in the external validation cohort. A webpage tool of MOP@COVID was developed to facilitate clinical application.
Conclusions
The MOP@COVID used routine laboratory test results at hospital admission and could predict the risk of in-hospital mortality in COVID-19 patients. With the webpage tool, MOP@COVID could provide helpful information to clinical doctors and healthcare providers in rural areas.