bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sentinel lymph node biopsy is accurate and prognostic in head and neck melanoma
Authors: Erman Audrey B. , Collar Ryan M. , Griffith Kent A. , Lowe Lori , Sabel Michael S. , Bichakjian Christopher K. , Wong Sandra L. , McLean Scott A. , Rees Riley S. , Johnson Timothy M. , Bradford Carol R. 
Published: July 2011

AbstractBACKGROUND:Sentinel lymph node biopsy (SLNB) has emerged as a widely used staging procedure for cutaneous melanoma. However, debate remains around the accuracy and prognostic implications of SLNB for cutaneous melanoma arising in the head and neck, as previous reports have demonstrated inferior results to those in nonhead and neck regions. Through the largest single‐institution series of head and neck melanoma patients, the authors set out to demonstrate that SLNB accuracy and prognostic value in the head and neck region are comparable to other sites.METHODS:A prospectively collected database was queried for cutaneous head and neck melanoma patients who underwent SLNB at the University of Michigan between 1997 and 2007. Primary endpoints included SLNB result, time to recurrence, site of recurrence, and date and cause of death. Multivariate models were constructed for analyses.RESULTS:Three hundred fifty‐three patients were identified. A sentinel lymph node was identified in 352 of 353 patients (99.7%). Sixty‐nine of the 353 (19.6%) patients had a positive SLNB. Seventeen of 68 patients (25%) undergoing completion lymphadenectomy after a positive SLNB result had at least 1 additional positive nonsentinel lymph node. Patients with local control and a negative SLNB failed regionally in 4.2% of cases. Multivariate analysis revealed positive SLNB status to be the most prognostic clinicopathologic predictor of poor outcome; hazard ratio was 4.23 for SLNB status and recurrence‐free survival (P < .0001) and 3.33 for overall survival (P < .0001).CONCLUSIONS:SLNB is accurate and its results are of prognostic importance for head and neck melanoma patients. Cancer 2012;. © 2011 American Cancer Society.
Impact of radiotherapy on laryngeal cancer survival
Authors: Zhang Hong , Travis Lois B. , Chen Rui , Hyrien Ollivier , Milano Michael T. , Newlands Shawn D. , Chen Yuhchyau 
Published: July 2011

AbstractBACKGROUND:Radiotherapy with its advantage of organ preservation has been used to treat laryngeal cancer (LC) for several decades. However, the impact of radiation on overall survival (OS) in a large population‐based study has not been evaluated to date.METHODS:The authors analyzed all patients who had localized and/or regional glottic and supraglottic cancer in the Surveillance, Epidemiology, and End Results Program by comparing treatment trends and OS for the periods 1988 to 1993, 1994 to 1999, and 2000 to 2006. Kaplan‐Meier and logistic regression analyses were conducted to evaluate OS and the influence of patient demographics on treatment received.RESULTS:Among 13,808 patients with LC, radiotherapy use increased over the 3 periods for localized glottic cancer (LGC) (94%, 97%, and 98% during 1988‐1993, 1994‐1999, and 2000‐2006, respectively; P < .001); for regional glottic cancer (RGC) (53%, 66%, and 75%, respectively; P < .001), for localized supraglottic cancer (LSGC) (61%, 83%, and 94%, respectively), and for regional supraglottic cancer (RSGC) (43%, 55%, and 78%, respectively; P < .001). No significant decrease in 5‐year OS was observed during the 3 periods (LGC: 73%, 76%, and 78%, respectively; RGC: 57%, 51%, and 56%, respectively; LSGC: 33%, 35%, and 39%, respectively; and RSGC: 36%, 36%, and 43%, respectively). Blacks were significantly less likely to receive radiotherapy than whites (odds ratio: LGC, 0.42; RGC, 0.76; RSGC, 0.68; all P < .05). Those in the lowest tertile of median household income, compared with highest tertile, received radiotherapy less frequently (odds ratio: LGC, 0.42; RGC, 0.57; RSGC, 0.57; all P < .001).CONCLUSIONS:The current results indicated that the increased use of radiation with its advantage of speech preservation had no adverse impact on the survival of patients with LC. Black race and low income status had significant, inverse relations with the receipt of radiotherapy. Cancer 2012;. © 2011 American Cancer Society.
Comparison between intravesical and oral administration of 5‐aminolevulinic acid in the clinical benefit of photodynamic diagnosis for nonmuscle invasive bladder cancer
Authors: Inoue Keiji , Fukuhara Hideo , Shimamoto Tsutomu , Kamada Masayuki , Iiyama Tatsuo , Miyamura Mitsuhiko , Kurabayashi Atsushi , Furihata Mutsuo , Tanimura Masanobu , Watanabe Hironobu , Shuin Taro 
Published: July 2011

AbstractBACKGROUND:This study was undertaken to evaluate the clinical value of photodynamic diagnosis (PDD) with intravesical and oral instillation of 5‐aminolevulinic acid (ALA) (ALA‐PDD), and transurethral resection of bladder tumor (TURBT) guided by ALA‐PDD (PDD‐TURBT) for nonmuscle invasive bladder cancer.METHODS:Of all 210 cases, 75 underwent PDD with intravesically applied ALA, and 135 cases underwent PDD with orally applied ALA. Diagnostic accuracy was evaluated by comparing the level on images of ALA‐induced fluorescence with the pathological result. PDD‐TURBT was performed in 99 completely resectable cases corresponding to 210 ALA‐PDD cases. To evaluate the abilities of PDD‐TURBT, survival analysis regarding intravesical recurrence was retrospectively compared with the historical control cases that underwent conventional TURBT.RESULTS:The diagnostic accuracy and capability of ALA‐PDD were significantly superior to those of conventional endoscopic examination. Moreover, 72.1% of flat lesions, including dysplasia and carcinoma in situ, could be detected only by ALA‐PDD. The recurrence‐free survival rate in the cases that underwent PDD‐TURBT was significantly higher than that of conventional TURBT. Moreover, multivariate analysis revealed that the only independent factor contributing to improving prognosis was PDD‐TURBT (hazard ratio, 0.578; P = .012). Regardless of the ALA administration route, there was no significant difference in diagnostic accuracy, ability of PDD, or recurrence‐free survival. All procedures were well tolerated by all patients without any severe adverse events.CONCLUSIONS:This multicenter study is likely to be biased, because it is limited by the retrospective analysis. This study suggests that regardless of the ALA administration route, ALA‐PDD and PDD‐TURBT are remarkably helpful in detection and intraoperative navigation programs. Cancer 2012;. © 2011 American Cancer Society.
Diagnostic and prognostic information obtained on fine‐needle aspirates of primary neuroblastic tumors
Authors: Klijanienko Jerzy , Couturier Jérôme , Brisse Hervé , Pierron Gaëlle , Fréneaux Paul , Berger Frédérique , Maciorowski Zofia , Sastre‐Garau Xavier , Michon Jean , Schleiermacher Gudrun 
Published: July 2011

AbstractBACKGROUND:The use of cytological material for diagnosis and prognosis in patients with neuroblastic tumors is poorly described in the literature.METHODS:A total of 129 patients with primary neuroblastic tumors underwent sampling with fine‐needle aspiration for diagnosis and the evaluation of prognostic parameters. Of these, 125 (97%) were neuroblastomas or ganglioneuroblastomas and 4 (3%) were ganglioneuromas. Cellularity of the smears was assessed, as well as the percentage of neuroblasts versus stroma, maturation (differentiating/mature vs immature cells), the mitosis‐karyorrhexis index (MKI), and the number of Homer Wright rosettes. The cytology samples were also analyzed for MYCN amplification, flow cytometric DNA index, and array comparative genomic hybridization.RESULTS:MYCN was found to be amplified in 35 (27%) cases. Strong correlations with overall survival were found for MYCN amplification in localized stages including IVs (P < .001), the percentage of neuroblasts versus stroma (P < .001), maturation (P = .002), MKI (P < .001), and DNA index (P < .03).CONCLUSIONS:Poorly differentiated tumors with few stromal components and low numbers of differentiating/mature cells were found to be MYCN amplified. The authors propose a “cytology prognostic score” in which neuroblastomas comprised of predominantly neuroblastic elements with no differentiating cells and an MKI >; 2% are classified as high‐risk tumors, regardless of their MYCN amplification status. The use of this proposed score would ensure accurate and optimal diagnostic and prognostic classifications of neuroblastic tumors in cases in which the histological biopsy is absent or inadequate for analysis. Cancer (Cancer Cytopathol) 2011;. © 2011 American Cancer Society.
Histopathologic follow‐up and human papillomavirus DNA test results in 290 patients with high–grade squamous intraepithelial lesion papanicolaou test results
Authors: Gao Faye F. , Austin R. Marshall , Zhao Chengquan 
Published: July 2011

AbstractBACKGROUND:The study documents histopathologic outcomes and high‐risk (hr) human papillomavirus (HPV) test results in a large cohort of patients with high‐grade squamous intraepithelial lesion (HSIL) liquid‐based cytology (LBC) Pap test results.METHODS:A total of 352 patients with HSIL results (338 cervical and 14 vaginal) who had hrHPV testing and 290 patients with biopsy follow‐up were studied. hrHPV detection rates were compared at different ages, with or without an endocervical/transformation zone sample (EC/TZS), and for cervical and vaginal HSIL Pap smears. Histopathologic follow‐up findings were also compared. hrHPV‐negative HSIL slides were re‐evaluated in a blinded manner.RESULTS:A total of 325 of 338 (96.2%) cervical HSIL and 12 of 14 (87.5%) vaginal HSIL tested hrHPV‐positive. A total of 271 of 281 (96.4%) EC/TZS‐positive cervical HSIL and 54 of 57 (94.7%) EC/TZS‐negative cervical HSIL tested hrHPV‐positive. The percentage of hrHPV‐positive HSIL declined slightly with increasing age. 197 of 273 (72.3%) hrHPV‐positive cervical HSIL had histopathologic cervical intraepithelial neoplasia (CIN) 2/3+ follow‐up, including 8 squamous carcinomas, compared with 4 of 12 (33.3%) hrHPV‐negative HSIL with CIN2/3 (no carcinomas). 167 of 241 (69.2%) EC/TZS‐positive HSIL had CIN2/3+ follow‐up, compared with 34 of 44 (77.3%) EC/TZS‐negative HSIL. Equivocal HSIL morphology characterized some HPV‐negative HSIL without CIN2/3+ follow‐up.CONCLUSIONS:hrHPV was detected in LBC vials from 96.2% of 338 cervical HSIL and 85.7% of 14 vaginal HSIL. CIN2/3+ was significantly more likely with hrHPV‐positive cervical HSIL than with hrHPV‐negative cervical HSIL. Presence or absence of an EC/TZS did not significantly impact HSIL hrHPV or CIN2/3+ rates. Some hrHPV‐negative HSIL cases may represent HSIL cytologic mimics. Cancer (Cancer Cytopathol) 2011;. © 2011 American Cancer Society.
How do framing strategies influence the user's choice of content on the Web?
Authors: Constantiou Ioanna , Hoebel Natascha , Zicari Roberto V. 
Published: July 2011

SUMMARYA Web user is exposed to a large number of information services available from different sources. Online news is offered combined with relevant service attributes such as pictures, small text, users' recommendations, etc. We previously investigated the Web user's choice of online news, focusing on the trade‐offs between reputation and other service attributes, which may explain the user's choice of an unknown source, such as a blog. In the present study, we investigate the Web user's choice of online news in a multi‐attribute context. Our findings indicate that the most important service attribute is the accompanying text, followed by the source's reputation, then the percentage of readers recommending or having read the link, and then the picture. We further explore the trade‐offs between the attributes through simulations. These findings provide useful insights to practitioners on how to use the service attributes in the framing strategies in order to increase the probability of the choice of online news. Copyright © 2011 John Wiley & Sons, Ltd.
Psychometric Properties of the Dutch Inventories of Prolonged Grief for Children and Adolescents
Authors: Spuij Mariken , Prinzie Peter , Zijderlaan Jolanda , Stikkelbroek Yvonne , Dillen Let , de Roos Carlijn , Boelen Paul A. 
Published: July 2011

A significant minority of bereaved adults develops prolonged grief disorder (PGD), a syndrome encompassing debilitating symptoms of grief distinct from depression and anxiety. Few studies have examined the phenomenology and correlates of PGD among children and adolescents. In part, this is due to the lack of a psychometrically sound questionnaire to assess PGD symptoms in these groups. Based on an adult measure of PGD, we developed two questionnaires of PGD symptoms for children and adolescents named the Inventory of Prolonged Grief for Children (IPG‐C) and Inventory of Prolonged Grief for Adolescents (IPG‐A), respectively. Psychometric properties of these measures were examined in three samples, including mostly parentally bereaved children (aged 8–12 years, total sample n = 169) and adolescents (aged 13–18 years, total sample n = 153). First, findings showed that items of the IPG‐C and IPG‐A represented one underlying dimension. Second, the internal consistency and temporal stability of both questionnaires were adequate. Third, findings supported the concurrent validity (e.g., significant correlations with measures of depression and post‐traumatic stress‐disorder [PTSD]), convergent and divergent validity (stronger correlations with similar questionnaires of ‘traumatic grief’ than with two dissimilar questionnaires of ‘ongoing presence’ and ‘positive memories’) and incremental validity (significant correlations with an index of functional impairment, even when controlling for concomitant depression and PTSD) of the IPG‐C and IPG‐A. This report provides further evidence of the clinical significance of PGD symptoms among children and adolescents and promising psychometric properties of questionnaires that can be used to assess these symptoms. Copyright © 2011 John Wiley & Sons, Ltd.Key Practitioner Message

The Inventory of Prolonged Grief for Children (IPG‐C) and Inventory of Prolonged Grief for Adolescents (IPG‐A) were developed to be able to assess symptoms of Prolonged Grief Disorder (PGD) among children and adolescents.
In different samples, the internal consistency, temporal stability, and concurrent and construct validity of these questionnaires were found to be adequate.
The IPG‐C and the IPG‐A can be used in research examining causes and consequences of PGD, and the effectiveness of bereavement interventions for children and adolescents.
This study provides further evidence of the existence and clinical significance of PGD symptoms among children and adolescents and supports the inclusion of a new category for bereavement‐related disorders in DSM‐5.
ABCG2 is required to control the sonic hedgehog pathway in side population cells with stem‐like properties
Authors: Balbuena Jana , Pachon Gisela , Lopez‐Torrents Guillermo , Aran Josep M. , Castresana Javier S. , Petriz Jordi 
Published: July 2011

AbstractThe Sonic Hedgehog (Hh) pathway has been implicated in the maintenance of stem or progenitor cells in many adult tissues. Importantly, abnormal Hh pathway activation is also associated with initiation of neoplasia, but its role in tumor growth is still unclear. Here, we demonstrate that cyclopamine, a plant‐derived alkaloid product used to inhibit the Hh signaling pathway, reduces the Side Population (SP) obtained by Hoechst 33342 (Ho342) dye measurements. In addition, cyclopamine is able to modulate, along with oxysterols and other products, the ABCG2 transporter by increasing Ho342 and mitoxantrone uptake. Therefore, if the SP is solely measured as a Ho342 dye extruding fraction, this may be significantly modulated by the inhibition of ABCG2 transport fraction, independently from the action of cyclopamine on the Hh pathway. Our results indicate that ABCG2 may act in the upstream regulation of the Hh signaling pathway to protect the stemness of the SP compartment, giving support to the cancer stem cell hypothesis and suggesting that ABCG2 is not only critical for increased resistance to anticancer agents. © 2011 International Society for Advancement of Cytometry
ISHAGE protocol: Are we doing it correctly?
Authors: Whitby Alison , Whitby Liam , Fletcher Matthew , Reilly John T. , Sutherland D. Robert , Keeney Michael , Barnett David 
Published: July 2011

AbstractBackground:Flow cytometric CD34+ stem cell enumeration is routinely performed to optimize timing of peripheral blood stem cell collections and assess engraftment capability of the apheresis product. While a number of different flow methodologies have been described, the highly standardized ISHAGE protocol is currently the most widely employed, with 204/255 (81%) international participants in the UK NEQAS CD34+ stem cell enumeration program indicating their use of this method. Recently, two laboratories were identified as persistent poor performers, a fact attributed to incorrect ISHAGE protocol usage/setup. This prompted UK NEQAS to question whether other laboratories were making similar errors and, if so, how this might affect individual EQA performance.Methods and Results:In send out 0801, where two stabilized samples were issued, the EQA center surveyed 255 participants with flow analysis data and subsequent results collected. One hundred and ninety‐six laboratories returned results with 103 returning dot plots. Eighty‐three out of one hundred and three stated that they used the ISHAGE protocol gating strategy but 43% (36/83) were incorrectly set‐up. Analysis of the data showed those incorrectly using single platform ISHAGE gating strategy were twice as likely to fail an EQA exercise compared to those using the protocol correctly. This failure rate increased two fold when incorrect ISHAGE protocol was used in a dual platform setting.Conclusion:This study suggests a widespread fundamental lack of understanding of the ISHAGE protocol and the need to deploy it correctly, potentially having significant clinical implications and highlights the need to monitor participants rigorously in their deployment of the ISHAGE protocol. It is hoped that once these findings have been disseminated, performance can be improved. © 2011 International Clinical Cytometry Society
Normal levels of peripheral CD19+CD5+ CLL‐like cells: Toward a defined threshold for CLL follow‐up—A GEIL‐GOELAMS study
Authors: Durrieu Françoise , Geneviève Franck , Arnoulet Christine , Brumpt Caren , Capiod Jean‐Claude , Degenne Michel , Feuillard Jean , Garand Richard , Kara‐Terki Amina , Kulhein Emilienne , Maynadié Marc , Ochoa‐Noguera Maria‐Elena , Plesa Adriana , Roussel Mikael , Eghbali Houchingue , Truchan‐Graczyk Matgorzata , de Carvalho Bittencourt Marcelo , Feugier Pierre , Béné Marie C. 
Published: July 2011

AbstractBackground:The development of flow cytometry as a useful tool for the detection of minimal residual disease (MRD) in chronic lymphocytic leukemia (CLL) is potentially hampered by the fact that a normal subset of B‐cells with a similar immunophenotype is present in the peripheral blood. This subset of CLL‐like cells is not well defined in terms of frequency.Methods:Here, we performed a multicenter study with a panel of four‐color antibody combinations possibly useful for the detection of MRD in CLL, to establish the levels of normal CLL‐like cells in 49 healthy controls. ROC curves established the upper level of such cells at 4 × 10−4. The two best combinations were further applied to 419 samples from 117 treated CLL patients.Results:The combinations CD19/CD5/CD43/CD79b and CD19/CD5/CD81/CD22 appeared very robust and well correlated to enumerate normal CLL‐like cells in a lysis no‐wash approach. In follow‐up samples from CLL patients, they disclosed only 9.8% of the samples within the normal range. In more than 90% of the cases, it was thus possible to report confidently on the absence or presence of MRD in these patients.Conclusions:This manuscript reports on the frequency of CD19+CD5+ B‐cells in normal peripheral blood and confirms the combinations recommended by the European research initiative on CLL as being performing to assess remaining CLL cells above a threshold of 4 × 10−4 white blood cells. © 2011 International Clinical Cytometry Society
Metal Anions in Metal‐Rich Compounds and Polar Intermetallics
Authors: Whangbo Myung‐Hwan , Lee Changhoon , Köhler Jürgen 
Published: July 2011

AbstractWe briefly surveyed metal‐rich and intermetallic compounds containing metal anions that have been characterized by density functional calculations. Transition metal anions come with electron configurations (n+1)s2nd10(n+1)p0, (n+1)s2nd10(n+1)p1, and (n+1)s2nd10(n+1)p2. Their nd orbitals act asreservoirs for holding ten electrons. Thus, these anions exhibit bonding characteristics similar to those found for their main group analogues.
Trivalent Rare Earth Complexes of the Unsymmetrical 3‐(2′‐Thienyl)‐5‐(trifluoromethyl)pyrazolate Ligand
Authors: Deacon Glen B. , Junk Peter C. , Urbatsch Aron 
Published: July 2011

AbstractTrivalent rare earth complexes of the unsymmetrical 3‐(2′‐thienyl)‐5‐(trifluoromethyl)pyrazolate (ttfpz) ligand, namely [RE(ttfpz)3(thf)3]·nsolv, where thf = tetrahydrofuran [RE = La, solv = PhMe, n = 0.5 (1); RE = Sm, n = 0 (2); RE = Tb, solv = thf, n = 1 (3)], [RE(ttfpz)3(thf)2] [RE = Y (4), Ho (5), Lu (6), Sc (7)] and [RE(ttfpz)3(dme)2]·nsolv, where dme = 1,2‐dimethoxyethane [RE = La, n = 0 (8a); RE = La, solv = Et2O, n = 0.5 (8b); RE = Eu, solv = dme, n = 1 (9)], were prepared, mainly by redox transmetallation/protolysis from the free metal, Hg(C6F5)2 and ttfpzH, and structurally characterised. In the nine‐coordinate, pseudo‐octahedral complexes 1 and 2, η2‐pyrazolate and thf ligands are in a facial arrangement, whereas they are arranged meridionally in 3. In the eight‐coordinate complexes 4–7 the arrangement of the η2‐pyrazolate and thf ligands can be described as in between pseudo‐trigonal bipyramidal and ‐square pyramidal. Ten‐coordinate complexes 8a, 8b and 9 exhibit η2‐bonded pyrazolates and two chelating dme ligands as opposed to the nine‐coordinate 3,5‐diphenylpyrazolate (Ph2pz) complexes [RE(Ph2pz)3(dme)2], which possess one unidentate and one chelating dme ligand, suggesting that the ttfpz ligand is less bulky than Ph2pz.
Ru‐ and Pd‐Catalysed Synthesis of 2‐Arylfurans by One‐Flask Heck Arylation/Oxidation
Authors: Schmidt Bernd , Geißler Diana 
Published: July 2011

Abstract2,5‐Disubstituted furans were synthesized by one‐flask Heck arylation/oxidation sequences. The starting materials are 2‐substituted 2,3‐dihydrofurans, conveniently available by RCM/isomerization sequences, and arenediazonium salts. These react in ligand‐free Heck reactions to afford 2,5‐disubstituted 2,5‐dihydrofurans, which are oxidized to the corresponding furans without isolation or intermediate workup. The oxidation is conveniently achieved with chloranil or DDQ, depending on the substrate.
Metal‐Free Ring Expansions of Methylenecyclopropanes Through Nitrene Equivalent
Authors: Zhang Di‐Han , Wei Yin , Shi Min 
Published: July 2011

AbstractAn interesting nitrene equivalent mediated metal‐free ring expansion of methylenecyclopropanes was developed in the presence of iodosobenzene diacetate (PIDA) and 3‐amino‐2‐ethyl‐4(3H)‐quinazolinone under mild conditions. A variety of cyclobutylidene hydrazine derivatives were obtained in moderate to excellent yields as separable (Z)/(E) isomeric mixtures.
A Straightforward Synthesis of Pyrazolines and Pyrazoles: Palladium‐Catalyzed Carbonylative Vinylation–Cyclocondensation Reactions of Aryl Halides
Authors: Wu Xiao‐Feng , Neumann Helfried , Beller Matthias 
Published: July 2011

AbstractA novel consecutive one‐pot synthesis of pyrazolines and pyrazoles starting from simple aryl halides, styrenes, carbon monoxide, and hydrazines has been established. Palladium‐catalyzed carbonylative vinylation of aryl halides gave the corresponding chalcones, which are trapped in situ by addition of hydrazines.