bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-effectiveness analysis of the geko™ device (an NMES technology) in managing venous leg ulcers in UK healthcare setting
Authors: Tuson Richard , Metry Andrew , Harding Keith 
Published: June 2024

AbstractObjectiveThis study evaluates the cost-effectiveness of the geko device a neuromuscular electro-stimulator (NMES) technology with standard of care versus standard of care alone for venous leg ulcers treatment, from the UK National Health Service perspective over 12 months.SettingResearch was conducted across NHS UK facilities, primarily within community services and outpatient leg ulcer clinics, encompassing a total of 51 patients.MethodA partitioned survival model, based on a two-arm randomised controlled trial, assessed wound healing rates using Kaplan–Meier curves and parametric extrapolations over a 12-month time horizon. Costs were derived from UK reference costs the British National Formulary, and the Personal Social Services Research Unit (2021/22). The primary outcome measured was the incremental cost per quality-adjusted life-year gained. The geko device provides additional benefits by stimulating the lateral popliteal nerve, augmenting venous, arterial and microvascular flow.ResultsThe addition of the geko device to standard of care significantly enhanced outcomes, increasing healing probability by 68% compared to standard of care. This integration would result in a cost saving of £774.14 per patient when compared to the standard of care alone across the NHS. Economic analyses indicate that integrating the geko device into standard of care protocols would reduce the overall NHS expenditure on venous leg ulcer wound management by as much as 15%. The approach also positively impacted health-related quality of life.ConclusionThe geko™ device when used adjunctively with standard of care would be a cost-effective method for managing chronic venous leg ulcers within the NHS, improving healing rates and offering economic benefits.Key messagesEnhanced Healing RatesThe addition of the geko™ device (an NMES technology) to standard of care significantly increases the probability of healing in patients with chronic venous leg ulcers.Economic AdvantageIncorporating the geko device into standard of care would lead to a reduction in the overall costs of wound management in the NHS, potentially up to 15%.Cost-EffectivenessThe combination of the geko device and standard of care demonstrates cost-effectiveness, offering a favourable balance between costs and quality-adjusted life years gained.Improved Quality of LifeThe use of the geko device in addition to standard of care impacts positively the health-related quality of life for patients.Consistent Outcomes in Sensitivity AnalysisSensitivity analyses support the cost dominance of the combined treatment approach, indicating robustness in various scenarios.Policy ImplicationsThese findings suggest that the integration of the geko device technology would be a viable policy option for enhancing venous leg ulcer treatment within the NHS.
Innovative COVID-19 Point-of-Care Diagnostics Suitable for Tuberculosis Diagnosis: A Scoping Review
Authors: Holtgrewe Lydia , Jain Sonal , Dekova Ralitza , Broger Tobias , Isaacs Chris , Nahid Payam , Cattamanchi Adithya , Denkinger Claudia M. , Yerlikaya Seda 
Published: June 2024

AbstractIntroductionRapid and accurate point-of-care (POC) tuberculosis (TB) diagnostics are a key priority to close the TB diagnostic gap of 3.1 million people without a diagnosis. Leveraging the recent surge in COVID-19 diagnostic innovation, we explored the potential adaptation of commercially available SARS-CoV-2 tests for TB diagnosis, aligning with World Health Organization (WHO) target product profiles (TPPs).MethodsA scoping review was conducted following PRISMA-ScR guidelines to systematically map commercially available POC molecular and antigen SARS-CoV-2 diagnostic tests potentially meeting the TPPs for TB diagnostic tests for peripheral settings. Data were gathered from PubMed/MEDLINE, bioRxiv, and medRxiv, along with publicly accessible in vitro diagnostic test databases, and developer websites, up to November 23, 2022. Data on developer and test attributes, operational characteristics, pricing, and clinical performance were charted using standardized data extraction forms. Each identified test was evaluated using a standardized scorecard. A narrative synthesis of the charted data is presented.ResultsOur database search yielded 2,003 studies, from which 408 were considered eligible. Among these, we identified 58 commercialized diagnostic devices, including 17 near-POC antigen tests, one POC molecular test, 29 near-POC molecular tests, and 11 low-complexity molecular tests. We summarized the detailed characteristics, regulatory status, and clinical performance data of these tests. The LumiraDx (Roche, Switzerland) emerged as the highest- scoring near-POC antigen platform, while Visby (Visby, USA) was the highest-performing near-POC molecular platform. The Lucira Check-It (Pfizer, USA) was noted as the sole POC molecular test. The IdyllaTM(Biocartis, Switzerland) was identified as the leading low- complexity molecular test.DiscussionWe highlight a diverse landscape of commercially available diagnostic tests suitable for potential adaptation to TB POC testing. This work aims to bolster global TB initiatives by fostering stakeholder collaboration, leveraging COVID-19 diagnostic technologies for TB diagnosis, and uncovering new commercial avenues to tackle longstanding challenges in TB diagnosis.
Do promoters cause financial distress in a bank?
Authors: Rastogi Shailesh , Kanoujiya Jagjeevan 
Published: June 2024

Purpose
The study aims to explore the impact of ownership concentration (OC) on bank financial distress (FD). Furthermore, the bank’s financial stability levels determine the association between the two.

Design/methodology/approach
Bank data of 33 Indian commercial banks are procured for ten years (2013–2022). The panel data econometrics is applied for empirical estimations. The quantile regression approach is used to determine the association between OC and FD at different quantiles of the FD. Non-normalcy of the data is checked and ensured before applying the quantile regression.

Findings
Surprisingly, it is found that promoters have a nonlinear impact on the firm’s stability. The inverted U-shape result implies that as promoters cross a threshold level, the benefit of increasing promoters’ stake takes a beating and a further increase in promoters’ stakes adversely impacts the stability of the banks. Moreover, this threshold value increases while moving from low to high levels of stability in a quantile regression application.

Research limitations/implications
This study uses promoters as the proxy for OC. Other existing definitions of OC are not used in the study, which can further improve the robustness of the results. Additionally, the use of the type of ownership (private, public or foreign) is also not adopted in the present study. Both the limitations can be the study’s future scope on the topic.

Practical implications
The high OC is supposed to influence corporate governance adversely. Therefore, policymakers recommend low OC for better governance. However, the present study finds evidence that a higher OC (high threshold of OC as the stability increases) would be better for financial stability. This situation demands a trade-off between governance and financial stability regarding OC.

Originality/value
The authors do not observe any study having the nonlinear impact of OC on financial stability (opposite of FD). Moreover, the threshold of OC for the optimum level of financial stability increases as stability goes high. This evidence using quantile regression and finding the turning point using a quadratic equation is also not seen in the literature.
A systematic literature review of Japanese SMEs: trends, challenges and insights for future research and practice
Authors: Elbanna Said , Begum Fareed , Mauji Nasrina 
Published: June 2024

Purpose
The distinctiveness of Japanese management practices offers invaluable insights for the strategic development and operational excellence of small and medium-sized enterprises (SMEs) worldwide. Recognizing this, the purpose of this study is to explore an extensive review of the literature on Japanese SMEs. The aim is to reveal previously explored research domains and to systematically categorize the unique factors contributing to the success and challenges of SMEs. This investigation not only illuminates the peculiarities of Japanese SMEs management but also sets the stage for applying these insights globally to SMEs across diverse industries.

Design/methodology/approach
Using a systematic review approach, 63 studies on Japanese SMEs from 1996 to 2021 were identified and analyzed.

Findings
This analysis identified six critical themes in Japanese SME management: nuanced firm management practices; forefront innovation and technology; internationalization; supportive government policies; commitment to corporate social responsibility and sustainable development; and vibrant entrepreneurship. The authors also spotlight challenges like navigating global competition and adapting to rapid technological changes. These insights, alongside noted methodological gaps in existing literature, suggest fertile grounds for future research and hold significant implications for SMEs globally.

Originality/value
The investigation of Japanese SMEs in this study highlights valuable insights for SMEs, policymakers and scholars, as it represents a rich and distinctive research phenomenon with various organizational, cultural, economic and political implications.
Enterprising spirit rejuvenated: entrepreneurship education in shaping company employees' career commitment and turnover intentions
Authors: Chang Yu-Yu , Chang Wei-Shiun , Fadhil Ahmad 
Published: June 2024

PurposeEntrepreneurship education is widely regarded as a fundamental means of fostering individuals' entrepreneurial intentions. In this paper, we delve into a distinctive empirical context: the integration of entrepreneurship education within Indonesia’s nationwide higher education system since 2010. Our goal is to investigate how prior participation in mandatory entrepreneurship training by company employees influences their inclination to leave their current employment and initiate a new business.Design/methodology/approachWe employed structural equation modeling to analyze empirical data (n = 337) collected from full-time Indonesian employees in established companies.FindingsOur findings indicate that previous engagement in entrepreneurship education predicts employees' entrepreneurial intentions, leading to reduced commitment to their current careers and an increased likelihood of having intentions to pursue new ventures. By comparing two groups of participants, our results suggest that government-mandated entrepreneurship education in Indonesia has a more substantial impact on employees' entrepreneurial intentions and turnover intentions.Originality/valueThis study, based on a unique sample from Indonesia, explores the entrepreneurial entry of organizational employees and the long-term effects of entrepreneurship education.
Effect of meal timing and frequency on lipid profile in adults: an overview of systematic reviews and meta-analyses
Authors: Yong Alene Sze Jing , Koo Rosamund Wei Xin , Ng Choon Ming , Lee Shaun Wen Huey , Teoh Siew Li 
Published: June 2024

Purpose
Dyslipidaemia is an established risk factor for cardiovascular diseases. Calorie restriction and adopting a heart-healthy diet like the Mediterranean diet are the main dietary interventions for dyslipidaemia. Other dietary behaviours, such as changes in meal frequency and timing, are not included in the major dietary advice guidelines despite the potential correlation between eating patterns and lipid metabolism. This overview of systematic reviews and meta-analyses aims to summarise the effect of meal timing and frequency on lipid profile and make possible recommendations on which meal timing pattern is superior in reducing lipid levels.

Design/methodology/approach
According to the protocol published on PROSPERO (CRD42021248956), five databases were searched for systematic reviews and meta-analyses investigating the effects of meal timing and frequency on lipid profile in adults.

Findings
Five reviews were included, with two reviews on breakfast skipping and meal frequency, respectively, and one review on night-time eating. Increasing meal frequency while maintaining the total calorie intake was reported to reduce total cholesterol and low-density lipoprotein (LDL) levels with low- to moderate-quality evidence. There was a correlation between breakfast skipping and an undesirable increase in LDL levels with low-quality evidence. However, there needs to be more high-quality evidence to conclude the effect of dietary behaviours on blood lipid levels.

Originality/value
This overview provides a comprehensive summary of evidence examining the effects of meal timing and frequency on adult lipid profiles. The current low- or moderate-quality evidence could not support the recommendation of alteration of meal frequency as an alternative to conventional non-pharmacological treatments for dyslipidaemia.
Opinions of intensive care nurses on continuous renal replacement therapy: A qualitative study
Authors: Kılıç Gülşen , Eskigülek Yasemin , Erdoğan Bülent , Arpa Hilal , Erbaş Gizem , Baştürk Beyza 
Published: June 2024

AbstractIntroductionThis is a phenomenologically designed qualitative study conducted to explore and conceptualize the problems experienced by intensive care nurses caring for patients undergoing continuous renal replacement therapy.MethodsFace‐to‐face, semi‐structured interviews were conducted with the participants. The interviews were transcribed verbatim, then thematic analysis was conducted.ResultsThe study was conducted 12 intensive care nurses. As a result, 3 main and 6 sub‐themes were identified. The themes identified were changing routines, uncertainty in terms of patient benefit, and need for adaptation.ConclusionIt was found that nurses experienced challenges in providing care to patients undergoing continuous renal replacement therapy, spent more effort to prevent complications, and lacked information on the subject. It is recommended to consider institutional and individual actions to meet the educational needs of nurses for implementing continuous renal replacement therapy.
Vismodegib in Gorlin‐Goltz syndrome: A systematic review
Authors: Palmeiro Ana Gusmão , Carvalho Mélissa , Gonçalves Castro Cristina , Pimentel Bernardo , Catorze Goreti 
Published: June 2024

AbstractTreatment with Hedgehog Inhibitors in Gorlin‐Goltz syndrome (GGS) yields favourable objective clinical responses, yet secondary resistance and class‐related toxicity restrict treatment duration. This study aims to review current data on GGS patients undergoing vismodegib therapy, focusing on treatment duration, clinical outcomes and schedule modifications. A systematic search of the PubMed database was conducted for English articles from 1993 to 2023, identifying 31 papers suitable for inclusion. A total of 351 patients, with a mean age of 52 years, were analysed. The average treatment duration was 9.3 months for patients who discontinued treatment, and 25.1 months for those who continued vismodegib at the time this study was published. Vismodegib achieved a complete response rate of 44%. Treatment interruption predominantly occurred due to side effects (69.1%) and secondary resistance (9.1%). The use of alternative regimens, although not compromising efficacy, may enhance treatment compliance. Further investigations are warranted to ascertain the optimal treatment regimen and timeline for GGS patients. Schedule modifications offer promise in ameliorating side effects and facilitating long‐term treatment.
A pilot study of a brief and scalable psychosocial intervention for children and adolescents following disasters
Authors: Strauven Sarah , Dennison Meg J. , O'Donnell Meaghan L. , Cowlishaw Sean , Gibson Kari , Pedder David J. , Baur Jenelle , Nursey Jane , Cobham Vanessa E. 
Published: June 2024

AbstractObjectivesFollowing disaster exposure, a significant proportion of children/adolescents will develop levels of post‐traumatic stress symptoms (PTSS) that do not meet diagnostic threshold for PTSD, but which cause ongoing distress. This paper describes the development and pilot testing of a brief, scalable, psychosocial intervention. SOLAR‐Kids/Teens has been designed to be delivered by non‐mental health professionals (‘coaches’) to children/adolescents experiencing moderate levels of PTSS following disasters.MethodsAn international collaboration of experts developed The Skills fOr Life Adjustment and Resilience (SOLAR) for Kids and Teens programs. The programs were piloted—using a pre‐post mixed methods design—with 10 children and adolescents (8–18 years), with the aims of examining the feasibility of the program's delivery model as well as the program's potential usefulness.ResultsThe pilot data indicated that after 1 day of training and with ongoing supervision, the SOLAR program was safe and feasible for coaches to deliver to children/adolescents experiencing PTSS. Coaches reported increased knowledge (p = .001), confidence (p = .001) and skills (p = .006). The programs were acceptable to coaches, children/adolescents and parents. Parents and children/adolescents reported reductions in trauma and anxiety symptoms from pre‐ to post‐treatment, with moderate to large effect sizes.ConclusionsThe preliminary findings demonstrate that the SOLAR‐Kids/Teens program is feasible, acceptable and safe to be delivered by trained non‐mental health professionals to children and adolescents experiencing PTSS and anxiety following disaster exposure. Randomized controlled trials are required to evaluate the efficacy of the SOLAR‐Kids/Teens programs.
Long‐term cause‐specific mortality in adolescent and young adult Hodgkin lymphoma patients treated with contemporary regimens—A nationwide Danish cohort study
Authors: Rossetti Sára , Juul Sidsel Jacobsen , Eriksson Frank , Warming Peder Emil , Glinge Charlotte , El‐Galaly Tarec Christoffer , Haaber Christensen Jacob , Kamper Peter , de Nully Brown Peter , Gislason Gunnar Hilmar , Vestmø Maraldo Maja , Tfelt‐Hansen Jacob , Hutchings Martin 
Published: June 2024

SummaryThe documented treatment‐induced excess mortality in Hodgkin lymphoma (HL) has spurred important treatment changes over recent decades. This study aimed to examine mortality among young HL patients treated with contemporary strategies, including historical data comparison. This nationwide study included 1348 HL patients, diagnosed in 1995–2015 and aged 15–40 at diagnosis. Among the patients, 66.5% had Ann Arbor stage I–II and 33.5% had stage III–IV disease. With a median follow‐up of 14.76 years, 139 deaths occurred, yielding a 5‐year overall survival of 94.6%. Older age, advanced disease, earlier treatment periods and extensive regimens were associated with higher overall mortality risk. The cumulative risk of HL‐related death showed an initial sharp rise, with a plateau at 5.3% 10‐year post‐diagnosis. Deaths due to cardiovascular or pulmonary diseases and second cancers initially had minimal risk, gradually reaching 1.2% and 2.0% at the 20‐year mark respectively. HL cases had a 7.5‐fold higher mortality hazard than the background population. This study suggests that contemporary HL treatment still poses excess mortality risk, but recent changes have notably reduced overall and cause‐specific mortality compared to earlier eras. Balancing treatment efficacy and toxicity remains crucial, but our findings highlight improved outcomes with modern treatment approaches.
Management of Refractory Anaphylaxis: An Overview of Current Guidelines
Authors: Pouessel Guillaume , Dribin Timothy E. , Tacquard Charles , Tanno Luciana Kase , Cardona Victoria , Worm Margitta , Deschildre Antoine , Muraro Antonella , Garvey Lene H. , Turner Paul J. 
Published: June 2024

ABSTRACTIn this review, we compare different refractory anaphylaxis (RA) management guidelines focusing on cardiovascular involvement and best practice recommendations, discuss postulated pathogenic mechanisms underlining RA and highlight knowledge gaps and research priorities. There is a paucity of data supporting existing management guidelines. Therapeutic recommendations include the need for the timely administration of appropriate doses of aggressive fluid resuscitation and intravenous (IV) adrenaline in RA. The preferred second‐line vasopressor (noradrenaline, vasopressin, metaraminol and dopamine) is unknown. Most guidelines recommend IV glucagon for patients on beta‐blockers, despite a lack of evidence. The use of methylene blue or extracorporeal life support (ECLS) is also suggested as rescue therapy. Despite recent advances in understanding the pathogenesis of anaphylaxis, the factors that lead to a lack of response to the initial adrenaline and thus RA are unclear. Genetic factors, such as deficiency in platelet activating factor‐acetyl hydrolase or hereditary alpha‐tryptasaemia, mastocytosis may modulate reaction severity or response to treatment. Further research into the underlying pathophysiology of RA may help define potential new therapeutic approaches and reduce the morbidity and mortality of anaphylaxis.
Management of Infant Atopic Eczema to Prevent Severe Eczema and Food Allergy
Authors: Yamamoto‐Hanada Kiwako , Ohya Yukihiro 
Published: June 2024

ABSTRACTEarly intervention and active management of infant atopic eczema may play a crucial role in limiting eczema severity and preventing the onset of immediate‐type food allergy. Eczema management involves education, skincare and medications targeting skin inflammation and barrier repair. Topical corticosteroids are the mainstay of anti‐inflammatory therapy, with nonsteroidal options available for some infants. Proactive therapy, addressing subclinical inflammation, is useful for preventing eczema flares, especially in infants with recurrent eczema flares despite reactive therapy. In clinical practice, holistic consideration of overall infant and family health is essential. Providing advice on maternal stress management, nutritional guidance and recommendations for proper sleep and lifestyle is crucial for the well‐being of children and their families, not limited to eczema treatment alone.