bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonsteroidal Anti-inflammatory Drug Use and Risk of Adenomatous and Hyperplastic Polyps
Authors: Murff Harvey J. , Shrubsole Martha J. , Chen Zhi , Smalley Walter E. , Chen Heidi , Shyr Yu , Ness Reid M. , Zheng Wei 
Published: July 2011

Abstract
Adenomatous polyps are known precursor lesions for colorectal cancer and some hyperplastic polyps also have malignant potential. The use of aspirin and nonsteroidal anti-inflammatory drugs (NSAID) is associated with a reduced risk of adenomatous polyps; however, less evidence exists with regard to NSAID use and hyperplastic polyp risk. We conducted a colonoscopy-based case–control study including 2,028 polyp cases (1,529 adenomatous and 499 hyperplastic) and 3,431 polyp-free controls. Multivariate logistic regression models were constructed to derived adjusted ORs and 95% CIs as the measure of the association between NSAID use and polyp risk. Use of baby aspirin, regular aspirin, and nonaspirin NSAIDs, were associated with a reduced risk of adenomatous polyps (OR = 0.79, 95% CI: 0.66–0.93, OR = 0.73, 95% CI: 0.58–0.90, and OR = 0.67, 95% CI: 0.53–0.86, respectively). Baby aspirin was also associated with a reduced risk of hyperplastic polyps (OR = 0.74, 0.56–0.97). Although a dose response was seen with adenoma risk and regular use of any NSAIDs (less than 7 doses per week, 7 doses per week, and greater than 7 doses per week), a dose response was not seen with hyperplastic polyps. We found no evidence of interaction between NSAID dose and duration and polyp risk. The use of any NSAID regardless of type was associated with a reduced risk of adenomatous polyps; however, regular aspirin and COX-2 inhibitors use was not associated with hyperplastic polyp risk. Cancer Prev Res; 4(11); 1799–807. ©2011 AACR.
Increased 90-Day Mortality in Patients With Acute Heart Failure With Elevated Copeptin
Authors: Maisel Alan , Xue Yang , Shah Kevin , Mueller Christian , Nowak Richard , Peacock W. Frank , Ponikowski Piotr , Mockel Martin , Hogan Christopher , Wu Alan H.B. , Richards Mark , Clopton Paul , Filippatos Gerasimos S. , Di Somma Salvatore , Anand Inder S. , Ng Leong , Daniels Lori B. , Neath Sean-Xavier , Christenson Robert , Potocki Mihael , McCord James , Terracciano Garret , Kremastinos Dimitrios , Hartmann Oliver , von Haehling Stephan , Bergmann Andreas , Morgenthaler Nils G. , Anker Stefan D. 
Published: July 2011

Background—
In patients with heart failure (HF), increased arginine vasopressin concentrations are associated with more severe disease, making arginine vasopressin an attractive target for therapy. However, AVP is difficult to measure due to its in vitro instability and rapid clearance. Copeptin, the C-terminal segment of preprovasopressin, is a stable and reliable surrogate biomarker for serum arginine vasopressin concentrations.

Methods and Results—

The Biomarkers in Acute Heart Failure (BACH) trial was a 15-center, diagnostic and prognostic study of 1641 patients with acute dyspnea; 557 patients with acute HF were included in this analysis. Copeptin and other biomarker measurements were performed by a core laboratory at the University of Maryland. Patients were followed for up to 90 days after initial evaluation for the primary end point of all-cause mortality, HF-related readmissions, and HF-related emergency department visits. Patients with copeptin concentrations in the highest quartile had increased 90-day mortality (
P
<0.001; hazard ratio, 3.85). Mortality was significantly increased in patients with elevated copeptin and hyponatremia (
P
<0.001; hazard ratio, 7.36). Combined end points of mortality, readmissions, and emergency department visits were significantly increased in patients with elevated copeptin. There was no correlation between copeptin and sodium (
r
=0.047).

Conclusions—
This study showed significantly increased 90-day mortality, readmissions, and emergency department visits in patients with elevated copeptin, especially in those with hyponatremia. Copeptin was highly prognostic for 90-day adverse events in patients with acute HF, adding prognostic value to clinical predictors, ser um sodium, and natriuretic peptides.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT00537628.
Nociceptive blink reflex and pain-related evoked potentials in hypnic headache
Authors: Holle Dagny , Gaul Charly , Krebs Sarah , Naegel Steffen , Diener Hans-Christoph , Kaube Holger , Katsarava Zaza , Obermann Mark 
Published: July 2011

Background: Central facilitation of trigeminal pain processing and deficient habituation was observed in different headache and facial pain disorders. This overactivation seems to be primarily associated with chronic pain states. Objective: To investigate the function of the trigeminal nociceptive system in patients with hypnic headache (HH). Methods: Fifteen HH patients according International Classification of Headache Disorders II criteria and 15 age- and gender-matched healthy controls were investigated using the nociceptive blink reflex (nBR) and trigeminal pain-related evoked potentials (PREP). Results: nBR and PREP responses showed no significant differences comparing HH patients and healthy controls. Moreover, no habituation deficit was detected in HH patients. Conclusion: Central facilitation and change in habituation do not seem to be a crucial part in the pathophysiology of HH despite the chronic nature of this disease. Facilitation or habituation deficit does not seem to be exclusively related to chronic pain disorders in general. Further research is needed to illuminate the pathophysiology of HH.
Microvascular decompression of the pterygopalatine ganglion in patients with refractory cluster headache
Authors: Oomen KPQ , Wijck AJM van , Hordijk GJ , Ru JA de 
Published: July 2011

Background: Cluster headache is an invalidating form of headache. Although cluster headache can be managed pharmacologically, some patients require surgical treatment with varying results. Microvascular decompression of the pterygopalatine ganglion could be an alternative to traditional surgical management in patients with cluster headache. Methods: Microvascular decompression of the pterygopalatine ganglion was performed in three patients with refractory cluster headache. The pterygopalatine artery was ligated and a temporal muscle graft was placed between the artery and the ganglion. Results: No differences were found between the presurgical period and 1 week, 1 month, 3 months, and 6 months postoperatively with respect to attack duration and frequency, visual analogue scale score during attacks and in remission periods, duration of remissions, and quality of life. Conclusion: These preliminary data suggest that microvascular decompression of the pterygopalatine ganglion does not provide pain reduction or improvement of quality of life in patients with refractory cluster headache.
The Treatment of Osteochondral Lesions of the Talus with Autologous Osteochondral Transplantation and Bone Marrow Aspirate Concentrate
Authors: Kennedy John G. , Murawski Christopher D. 
Published: July 2011

Objective: To present the functional results after autologous osteochondral transplantation with bone marrow aspirate concentrate in 72 patients, while placing an emphasis on the surgical technique. Methods: Between 2005 and 2009, 72 patients underwent autologous osteochondral transplantation under the care of the senior author. The mean patient age at the time of surgery was 34.19 years (range, 16-85 years). All patients were followed for a minimum of 1 year after surgery. The mean follow-up time was 28.02 months (range, 12-64 months). Patient-reported outcome measures were taken preoperatively and at final follow-up using the Foot and Ankle Outcome Score (FAOS) and Short Form–12 (SF-12) general health questionnaire. Identical questionnaires were used in all instances. Results: The mean FAOS scores improved from 52.67 points preoperatively to 86.19 points postoperatively (range, 71-100 points). The mean SF-12 scores also improved from 59.40 points preoperatively to 88.63 points postoperatively (range, 52-98 points). Three patients reported donor site knee pain after surgery, and one patient required the decompression of a cyst that developed beneath the graft site approximately 2 years after the index procedure. Conclusion: Autologous osteochondral transplantation is a reproducible and primary treatment strategy for large osteochondral lesions of the talus.
Chondral Defect Repair with Particulated Juvenile Cartilage Allograft
Authors: Farr Jack , Yao Jian Q 
Published: July 2011

Objective: This case study of 4 patients followed for at least 2 years was conducted to evaluate a cartilage repair procedure that involves transplanting particulated juvenile allograft cartilage. Design: A multicenter, prospective, single-arm, 25-subject case study was designed to evaluate clinical outcomes such as IKDC and KOOS scores as well as the extent and quality of repair with MRI. In addition, there is an option for the transplants to be biopsied at various time points after implantation (up to 5 years). Currently, 25 patients with 1 or 2 chondral lesions on the femoral condyles and trochlea have been enrolled and treated in the prospective study. Results: The first 4 patients have completed an evaluation at 24 months postoperative follow-up. Improvements in clinical outcomes over the preoperative baseline data have been observed. Conclusions: The present report describes, for the first time, clinical intermediate-term results of a novel cartilage repair procedure that involves transplanting particulated juvenile cartilage tissue allograft into prepared cartilage lesions of the femoral condyles and/or trochlea. Clinical outcome data of 4 patients who have reached the 24-month postimplantation milestone indicate early positive outcomes and suggest that this technique is capable of improving clinical symptoms. MRI data suggest that defect filling is possible and persists to at least 2 years. Continued clinical evaluation of this technique is needed with extended follow-up of all 25 patients in the series.
Note: A Reply to “New Product Diffusion Decisions Under Supply Constraints”
Authors: Ho Teck-Hua , Savin Sergei , Terwiesch Christian 
Published: July 2011

In our prior work on product diffusions in presence of a capacity constraint, we postulated that a firm operating in such an environment should always attempt to fulfill as much of the present demand as is possible with the capacity constraint. In other words, the firm would never have demand backlogged while accumulating inventory. In this note, we derive a sufficient condition for the optimality of such fulfillment policy. This paper was accepted by Candace A. Yano, operations management.
On multivariate calibration with unlabeled data
Authors: Gujral Paman , Amrhein Michael , Ergon Rolf , Wise Barry M. , Bonvin Dominique 
Published: July 2011

AbstractIn principal component regression (PCR) and partial least‐squares regression (PLSR), the use of unlabeled data, in addition to labeled data, helps stabilize the latent subspaces in the calibration step, typically leading to a lower prediction error. For using unlabeled data in PLSR, a non‐sequential approach based on optimal filtering (OF) has been proposed in the literature. In this work, a sequential version of the OF‐based PLSR and a PCA‐based PLSR (PLSR applied to PCA‐preprocessed data) are proposed. It is shown analytically that the sequential version of the OF‐based PLSR is equivalent to that of PCA‐based PLSR, which leads to a new interpretation of OF. Simulated and experimental data sets are used to point out the usefulness and pitfalls of using unlabeled data. Unlabeled data can replace labeled data to some extent, thereby leading to an economic benefit. However, in the presence of drift, the use of unlabeled data can result in an increase in prediction error compared to that obtained with a model based on labeled data alone. Copyright © 2011 John Wiley & Sons, Ltd.
Oncologic outcomes of partial versus radical nephrectomy for unilateral Wilms Tumor
Authors: Cost Nicholas G. , Lubahn Jessica D. , Granberg Candace F. , Schlomer Bruce J. , Wickiser Jonathan E. , Rakheja Dinesh , Gargollo Patricio C. , Leonard David , Raj Ganesh V. , Baker Linda A. , Margulis Vitaly 
Published: July 2011

AbstractBackgroundRadical nephrectomy (RN) is the recommended surgical management as part of multi‐modality therapy for unilateral Wilms tumor (UWT). Based on recent data demonstrating that renal preserving surgery decreases the likelihood of chronic renal disease and associated co‐morbidities, we analyzed oncologic outcomes of patients after partial nephrectomy (PN) for UWT.MethodsWe identified all published cases of PN for UWT. Cases of elective PN for UWT were analyzed for tumor stage, presence, timing and location of disease recurrence, and overall survival (OS). Eighty‐two patients had adequate data for analysis. For comparison, these endpoints were collected on consecutive children undergoing RN for UWT from 1985 to 2010 at our institution.ResultsOf the 82 PN patients, tumor stage was: I—64, II—10, III—6, IV—2. Of the 121 RN patients, the staging was: I—24, II—45, III—29, IV—23. In the PN group, at a median of 48 months (3–372), the recurrence‐free survival (RFS), local RFS and OS were 89.1%, 92.7%, and 95.1%, respectively. In the RN group, at a median of 69 months (0–214), the RFS, local RFS, and OS were 83.1%, 95.0%, and 95.0%, respectively. After controlling for stage, there were no statistically significant differences in the above oncologic outcomes between the groups.ConclusionBased on reported data, the oncologic outcomes of PN for UWT in selected patients do not appear to differ from those of RN. PN for appropriately selected patients with UWT should be studied in prospective, co‐operative group trials. Pediatr Blood Cancer 2012; 58: 898–904. © 2011 Wiley Periodicals, Inc.
Efficient and Specific Conversion of 9‐Lipoxygenase Hydroperoxides in the Beetroot. Formation of Pinellic Acid
Authors: Hamberg Mats , Olsson Ulrika 
Published: July 2011

AbstractThe linoleate 9‐lipoxygenase product 9(S)‐hydroperoxy‐10(E),12(Z)‐octadecadienoic acid was stirred with a crude enzyme preparation from the beetroot (Beta vulgaris ssp. vulgaris var. vulgaris) to afford a product consisting of 95% of 9(S),12(S),13(S)‐trihydroxy‐10(E)‐octadecenoic acid (pinellic acid). The linolenic acid‐derived hydroperoxide 9(S)‐hydroperoxy‐10(E),12(Z),15(Z)‐octadecatrienoic acid was converted in an analogous way into 9(S),12(S),13(S)‐trihydroxy‐10(E),15(Z)‐octadecadienoic acid (fulgidic acid). On the other hand, the 13‐lipoxygenase‐generated hydroperoxides of linoleic or linolenic acids failed to produce significant amounts of trihydroxy acids. Short‐time incubation of 9(S)‐hydroperoxy‐10(E),12(Z)‐octadecadienoic acid afforded the epoxy alcohol 12(R),13(S)‐epoxy‐9(S)‐hydroxy‐10(E)‐octadecenoic acid as the main product indicating the sequence 9‐hydroperoxide → epoxy alcohol → trihydroxy acid catalyzed by epoxy alcohol synthase and epoxide hydrolase activities, respectively. The high capacity of the enzyme system detected in beetroot combined with a simple isolation protocol made possible by the low amounts of endogenous lipids in the enzyme preparation offered an easy access to pinellic and fulgidic acids for use in biological and medical studies.
Acute treatment with the organochalcogen 3‐butyl‐1‐phenyl‐2‐(phenyltelluro)oct‐en‐1‐one produces behavioral changes and inhibition of creatine kinase activity in the brain of rats
Authors: Funchal Cláudia , de Andrade Rodrigo Binkowski , Turcatel Elias , Guerra Robson Brum , Wannmacher Clovis Milton Duval , Gomez Rosane 
Published: July 2011

AbstractOrganotellurium compounds have been synthesized since 1840, but their pharmacological and toxicological properties are still incipient. Therefore, the objective of this study was to verify the effect of acute administration with the organochalcogen 3‐butyl‐1‐phenyl‐2‐(phenyltelluro)oct‐en‐1‐one on the activity of brain creatine kinase (CK), a key enzyme in energy metabolism, and on behaviors in the open field test of 30‐day‐old rats. Animals were treated intraperitoneally with a single dose of the organotellurium (125, 250, or 500 μg/kg body weight) and after 55 min of the drug administration the open field test was carried out. Behavior analyses were performed during 5 min and the number of the squares crossed, number of rearing, number of groomings and number of fecal boli were recorded by an observer. Then, the animals were sacrificed and the cerebral cortex, the hippocampus, and the cerebellum were dissected, and CK activity and sulfhydryl content were measured in the brain. The organotellurium increased the ambulation and rearing behaviors in the open field test at doses of 250 and 500 μg/kg. Moreover, the compound inhibited CK activity and provoked a reduced of thiol content measured by the sulfhydryl assay in all the tissues studied. Therefore, changes in energy homeostasis and motor behavior in rats treated with this organotellurium support the hypotheses that the brain is a potential target to pharmacological and toxicological effects of this compound.
Multiple endorsers and multiple endorsements: The influence of message repetition, source congruence and involvement on brand attitudes
Authors: Rice Dan Hamilton , Kelting Katie , Lutz Richard J. 
Published: July 2011

AbstractThis paper investigates the effects of source congruence on brand attitudes in two situations: multiple brand endorsements by one celebrity and multiple celebrity endorsers of one brand. Under low involvement conditions, brand attitudes become more negative as a celebrity endorses multiple brands and more favorable with multiple endorsers. In high involvement conditions, strong source congruence overrides the negative effect of multiple brands, and the positive effect of multiple endorsers is found only with strong congruence. We interpret these results as suggestive of a frequency knowledge cue that dominates under low involvement but is non‐diagnostic in high involvement scenarios.
RETRACTED: Frequent alterations of LOH11CR2A, PIG8 and CHEK1 genes at chromosomal 11q24.1‐24.2 region in breast carcinoma: Clinical and prognostic implications
Authors: Sinha Satyabrata , Singh Ratnesh K. , Bhattacharya Nilanjana , Mukherjee Nupur , Ghosh Susmita , Alam Neyaz , Roy Anup , Roychoudhury Susanta , Panda Chinmay Kumar 
Published: July 2011

AbstractTo understand the importance of frequent deletions at chromosome 11q24.1‐24.2 region in breast carcinoma, alterations (deletion/methylation) of the candidate genes LOH11CR2A, ROBO3, ROBO4, HEPACAM, PIG8 and CHEK1 located in this region were analyzed in 106 breast carcinoma samples. Among these genes, LOH11CR2A showed highest frequency of deletion (56%), followed by PIG8 (35%), CHEK1 (31%) and ROBO3/ROBO4/HEPACAM loci (28%). Comparable frequency of promoter methylation (26–35%) was observed for LOH11CR2A, CHEK1 and PIG8. Overall alterations (deletion/methylation) of these genes were in the following order: LOH11CR2A (60%) > PIG8 (46%) > CHEK1 (41%) and showed significant association with each other. Breast carcinoma samples that were estrogen/progesterone receptor negative showed significantly high deletion and overall alterations than estrogen/progesterone receptor positive samples for LOH11CR2A, CHEK1 and PIG8. The methylation and overall alteration of LOH11CR2A were significantly associated with tumor stages in breast carcinoma. However, in early/late onset and estrogen/progesterone receptor positive/negative breast carcinoma, the overall alterations of LOH11CR2A, PIG8 and CHEK1 were differentially associated with advanced stages, tumor grade and lymph node metastasis. Alterations of PIG8 and CHEK1 were significantly associated with poor prognosis in patients with early age of onset of the disease indicating significant prognostic importance. Quantitative mRNA expression analysis detected reduced expression of the genes in the order LOH11CR2A > CHEK1 > PIG8. Immunohistochemical analysis showed reduced protein expression of PIG8 and CHEK1 that was concordant with their molecular alterations. Thus, our study suggests that LOH11CR2A, PIG8 and CHEK1 are candidate tumor suppressor genes associated with breast carcinoma and have significant clinical as well as prognostic importance.
Gesundheit in prekären Arbeitsverhältnissen
Authors: Mümken Sarah 
Published: July 2011

Einleitung
Obwohl prekär Beschäftigte im Hinblick auf ihre gesundheitliche Situation eine exponierte Gruppe bilden, steht die Forschung in diesem Bereich noch an ihren Anfängen. Bislang konzentrierten sich Studien zum Zusammenhang von Arbeit und Gesundheit vorrangig auf „klassische“ Vollzeitbeschäftigung und auch Unsicherheit in unterschiedlichster Form wird nur selten als Stressor untersucht.
Verhaltenspräventive Intervention in einem DAX-30 Industriebetrieb – Ergebnisse einer kontrollierten und randomisierten Studie
Authors: Gündel Harald , Limm Heribert , Heinmüller Mechthild , Marten-Mittag Birgitt , Angerer Peter 
Published: July 2011

Einleitung
Chronischer Stress am Arbeitsplatz erhöht das Risiko gravierender Gesundheitsstörungen. Nach Implementierung eines speziellen Stressbewältigungstrainings in einem Betrieb wurde der Langzeiteffekt untersucht. 174 Teilnehmer, randomisiert in Interventions- (IG) oder Warte-Kontrollgruppe (KG), nahmen teil. Eine zweifaktorielle Varianzanalyse belegte signifikant bessere Effekte bzgl. Stressreaktivität in der IG. α-Amylase, als Marker für die Sympathikusaktivierung, nahm in der IG stärker ab. Die Stressmanagement-Intervention erwies sich 1 Jahr nach Beginn der Intervention als wirksam.
Curriculum and pedagogy in Key Stage 2: a survey of policy and practice in small rural primary schools
Authors: Richards Colin 
Published: July 2011

ABSTRACTSmall primary schools have often been criticized for their staff's inevitably limited curricular expertise and consequent difficulty in providing a full National Curriculum for their pupils. Yet in terms of standards of attainment and quality of teaching such schools are rated rather more favourably than larger ones in OFSTED inspections. Based on an investigation of policy and practice in thirteen small primary schools this article attempts to examine the reality of small schools’ planning and implementation of National Curriculum requirements at Key Stage 2 and suggests possible reasons for their ‘better’ performance, at least as judged by OFSTED inspectors.
Photoluminescence characteristics of as-synthesized and annealed ZnS:Cu,Al nanocrystals
Authors: Nguyen Tri Tuan , Trinh Xuan Anh , Nguyen Le Hung , Pham Thanh Huy 
Published: July 2011

Abstract
As-synthesized ZnS:Cu,Al nanocrystals with average size of 2–3 nm show abroad emission band peaking at 445 nm (blue) and a shoulder at around 540 nm (green). Annealing the nanocrystals in nitrogen gas results in a reduction in the intensity of the blue emission while enhancing the intensity of the green emission band. The maximum of the green emission is first redshifted to around 590 nm when the annealing temperature is increased to 400 °C, and later blueshifted to 564 and 500 nm for the samples annealed at 500 °C and 600 °C for 1 h, respectively. The lower phase-transition temperature (from zinc blende to wurtzite) and the donor–acceptor pair luminescence process in nanocrystals are discussed.