bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using Recurrent Neural Networks for the Performance Analysis and Optimization of Stochastic Milkrun-Supplied Flow Lines
Authors: Südbeck Insa , Mindlina Julia , Schnabel André , Helber Stefan 
Published: April 2024

AbstractLong-term throughput, as a key performance indicator of a stochastic flow line, is affected by numerous parameters describing the features of the flow line, such as processing time and buffer size. Fast and accurate evaluation methods for a given set of values for those parameters are a prerequisite to systematically optimize such a flow line. In this paper, we consider the case of a flow line with random processing times, limited buffer capacities and so-called milkruns that supply the machines with material parts that are required to perform, e.g., assembly operations on workpieces. In such a system, shortages in the supply of material parts can limit the performance of the flow line. Up to now, there are no accurate analytical approaches to quantify the complex interactions in such milkrun-supplied flow lines for realistic problem sizes. We propose to use recurrent neural networks to determine the long-term throughput of such flow lines enabling us to evaluate production systems of flexible size. Our results show that the throughput can be determined accurately and quickly via recurrent neural networks. Furthermore, we use this new evaluation procedure as a building block to optimize this type of flow line using gradient and local search techniques.
Legal proof: why knowledge matters and knowing does not
Authors: Mueller Andy 
Published: April 2024

AbstractI discuss the knowledge account of legal proof in Moss (2023) and develop an alternative. The unifying thread throughout this article are reflections on the beyond reasonable doubt (BRD) standard of proof. In Section 1, I will introduce the details of Moss’s account and how she motivates it via the BRD standard. In Section 2, I will argue that there are important disanalogies between BRD and knowledge that undermine Moss’s argument. There is however another motivation for the knowledge account: combined with auxiliary claims, that is probabilistic knowledge and moral encroachment, it can provide a general solution to the puzzle of statistical evidence. Section 3 spells out the details. In Section 4, I suggest to combine the knowledge account with pragmatic encroachment, instead of moral encroachment, in order to stay clear of the thorny issues whether corporations have moral rights. In Section 5, I argue that the verdicts of Moss’s account in cases of false justified beliefs and non-luminous knowledge conflict with the BRD standard and thus call for abandoning the account. Based on the social function of the BRD standard, I suggest a replacement for the knowledge account that is also just as potent as a general solution for the puzzle of statistical evidence. While I will grant that knowledge is neither always necessary nor always sufficient for convictions, I will argue that the concept of knowledge nonetheless plays a significant and ineliminable role in legal decision-making.
Eutrophication in cold-arid lakes: molecular characteristics and transformation mechanism of DOM under microbial action at the ice-water interface
Authors: Wang Tengke , Feng Weiying , Liu Jing , Fan Wenhong , Li Tingting , Song Fanhao , Yang Fang , Liao Haiqing , Leppäranta Matti 
Published: April 2024

AbstractDuring freezing periods, nutrients (carbon and organic matter, etc.) are enriched in the water and sediment of lakes in cold-arid regions, leading to potential algal bloom outbreaks and other health risks to the ecosystem. Particularly, dissolved organic matter (DOM) is a critical component of the nutrients and plays an important role in the global carbon cycle. However, the mechanisms of DOM transfer between ice and water remain unclear. This study analyzed the influence of microbial community on DOM composition using 16 s RNA, 3DEEM, and FT-ICR MS in Daihai Lake and Wuliangsuhai Lake in the Yellow River Basin, China. According to the spectral analysis, the content of endogenous organic matter, such as humus, accounted for 40% of the total DOM in water, while the content of tryptophan and tyrosine accounted for 80% of the total DOM in ice. The results of mass spectrometry showed that lignin was the main component, and the content of organic matter in the ice was less than that in the water. Molecular structures of seven DOM coexisting in the lake ice and water were elucidated with adapted Kendrick-analogous network visualization, which clearly illustrates that long-chain DOM molecules are derived from small molecules, while other heteroatoms are complexed with the side groups. The positive correlations between CHO, CHNO, CHOS, CHOS and Actinomyces indicate that DOM actively interacted with the microbial community. 44% of CHO compounds have the same molecular formula in water, the content of CHOS in the water of the two lakes was closed to 7% higher than that in the ice. Meanwhile, DOM dynamically migrate between ice and water via interstitial water because of the solubility changes under microbial transformation, which has been proved by the decrease in the contents of the humus and tryptophan-like substances in the ice from the bottom to the surface and lower contents of carbohydrate and unsaturated aromatic hydrocarbon in the water than the ice. This study helps to predict the composition and structure of DOM during the migration in lakes and provides a scientific basis for environmental remediation with high concentration of carbon.
“I would prefer to be dead than to live this way”: Lived experiences of stigma and discrimination against khwaja sira in Swat, Pakistan
Authors: Azhar Sameena , Ahmad Imtyaz , Guzman Herrera Maria Mercedes , Tariq Nadeem , Lerner Riya 
Published: April 2024

Abstract
Due to their identification as third gender people, khwaja sira have historically been subjected to experiences of social marginalization. However, the extant literature has not fully explored the lived experiences of stigma and discrimination against khwaja sira in the Swat Valley of Khyber Pakhtunkhwa, Pakistan. To address this gap, we conducted 45 interviews with khwaja sira in Mingora, Swat, Khyber Pakhtunkhwa to better understand their experiences of gender-nonconformity stigma and discrimination in various social contexts, including within their families, in accessing health care, and within education and work contexts. Applying Minority Stress Theory and utilizing thematic content analysis, the present study identified three dimensions of gender-nonconformity stigma: (1) internalized stigma, namely feelings of shame and embarrassment; (2) perceived stigma, namely opinions others had of khwaja sira regarding lack of employability or engagement in sex work; and (3) enacted stigma, namely exclusion from families, in educational settings, in religious spaces, and in healthcare settings. Findings should inform future social intervention and community practice engagements with khwaja sira communities in Pakistan.
A new look at an ancient city: An outline of the chronological and urban development of the Hittite capital Ḫattuša
Authors: Schachner Andreas 
Published: April 2024

AbstractThe intense use of scientific dating over the last three decades makes it possible for the first time reasonably to connect the topographically diverse parts of the Hittite capital Ḫattuša. Not only was the decision to found a city at this site based on pre-Hittite parameters, but at the same time, it also becomes clear that the settlement is one of the very few in Anatolia which was continuously used from the end of the third millennium BC through the second millennium until the beginning of the Iron Age. Furthermore, the accumulation of radiocarbon dates in individual, archaeologically intensively studied areas of the site makes it now possible to understand the development as a dynamic and fluent process. Based on the results outlined here, permanent moves back and forth of the settled areas within a geographically defined space can be reconstructed. The Hittite city of Ḫattuša was always a construction site. Next to densely built-up districts there existed at all times large expanses of either ruins of buildings or of open spaces, which could have been used as pasture or arable land. The settlement’s map, regularly reproduced as its overall plan, thus represents a status reconstructed or idealised by modern research. Most probably the settlement was at no time occupied to this extent, and accordingly never looked like this in its history.
Polysomnographic parameters associated with cognitive function in patients with major depression and insomnia
Authors: Olivera-López Carlos , Jiménez-Genchi Alejandro , Ortega-Robles David , Valencia-Flores Matilde , Cansino Selene , Salvador-Cruz Judith 
Published: April 2024

AbstractObjectiveTo examine whether objective sleep parameters are associated with cognitive function (CF) in patients with major depressive disorder (MDD) with chronic insomnia (CI) and whether the severity of these disorders is related to CF.MethodThirty patients with MDD with CI attending a tertiary care institution underwent two consecutive nights of polysomnographic (PSG) recording and a battery of neuropsychological tests, which included episodic memory, sustained attention, working memory, and executive function. The severity of MDD and CI was assessed by clinical scales. We examined the relationship between PSG parameters and CF, as well as whether the severity of the disorders is related to CF.ResultsLinear regression analysis revealed that total sleep time (TST) was positively associated with higher learning and recall of episodic memory, as well as better attention. Slow-wave sleep (SWS) showed a positive association with better working memory. Furthermore, wake after sleep onset (WASO) was negatively associated with episodic memory and lower attention. No significant relationships were found between the severity of MDD or CI with CF.ConclusionBoth sleep duration and depth are positively associated with several aspects of CF in patients with MDD with CI. Conversely, a lack of sleep maintenance is negatively related to CF in these patients. These findings could help identify modifiable therapeutic targets to reduce CF impairment.
Projecting Changes in the Drivers of Compound Flooding in Europe Using CMIP6 Models
Authors: Hermans Tim H. J. , Busecke Julius J. M. , Wahl Thomas , Malagón‐Santos Víctor , Tadesse Michael G. , Jane Robert A. , van de Wal Roderik S. W. 
Published: April 2024

AbstractWhen different flooding drivers co‐occur, they can cause compound floods. Despite the potential impact of compound flooding, few studies have projected how the joint probability of flooding drivers may change. Furthermore, existing projections may not be very robust, as they are based on only 5 to 6 climate model simulations. Here, we use a large ensemble of simulations from the Coupled Model Intercomparison Project 6 (CMIP6) to project changes in the joint probability of extreme storm surges and precipitation at European tide gauges under a medium and high emissions scenario, enabled by data‐proximate cloud computing and statistical storm surge modeling. We find that the joint probability will increase in the northwest and decrease in most of the southwest of Europe. Averaged over Europe, the absolute magnitude of these changes is 36%–49% by 2080, depending on the scenario. The large‐scale changes in the joint probability of extreme storm surges and precipitation are similar to those in the joint probability of extreme wind speeds and precipitation, but locally, differences can exceed the changes themselves. Due to internal climate variability and inter‐model differences, projections based on simulations of only 5 to 6 randomly chosen CMIP6 models have a probability of higher than 10% to differ qualitatively from projections based on all CMIP6 simulations in multiple regions, especially under the medium emissions scenario and earlier in the twenty‐first century. Therefore, our results provide a more robust and less uncertain representation of changes in the potential for compound flooding in Europe than previous projections.
Strain Partitioning and Fault Kinematics in the Northern Qilian Shan (NE Tibet) Determined From Bayesian Inference of Geodetic Data
Authors: Zhang Yingfeng , Wimpenny Sam , Dal Zilio Luca , Shan Xinjan 
Published: April 2024

AbstractOblique convergence across the northern Qilian Shan is accommodated by sub‐parallel strike‐slip and thrust faults that ruptured simultaneously in the Mw 8 Gulang earthquake in 1927. We investigate the kinematics of fault loading in the northern Qilian Shan and provide insights into the conditions necessary for generating multi‐fault earthquakes. We perform Bayesian inversions for the geometry and creep rate on the fault network. We infer that all of the thrust faults are locked north of the Qilian‐Haiyuan strike‐slip fault and are accumulating elastic strain. Multi‐fault earthquakes may occurr in this fault system because the faults are simultaneously loaded by the same source of deformation and are linked together by locked fault segments. The interseismic velocity field alone can not contain the location or activity of individual faults visible in the geomorphology, therefore the short‐term geodetic measurements may not reliably indicate the long‐term behavior of the fault system.
Molecular Characterization of Gaseous Organic Acids and Nitrogen‐Containing Compounds From Crop Straw and Wood Burning
Authors: Zhou Wei , Xu Weiqi , Li Zhijie , Lei Lu , Li Yan , Sun Jiaxing , Du Aodong , Zhang Zhiqiang , Li Ying , Fu Pingqing , Ge Xinlei , Sun Yele 
Published: April 2024

AbstractBiomass burning serves as important sources of volatile organic compounds (VOCs), yet our understanding of the molecular characteristics of oxygenated volatile organic compounds (OVOCs) from fresh emissions remains limited. In this study, gaseous organic compounds in fresh smokes from burning typical Chinese crop straws and woods are measured using an iodide time‐of‐flight chemical ionization mass spectrometer. Approximately 750 molecular formulas are identified, with CHO compounds containing carbon, hydrogen and oxygen atoms accounting for 77%–95% of the total. C1–C3 organic acids and dicarboxylic acids dominate the total CHO signal intensities by 27%–48%, while well‐known molecular markers of biomass burning, such as monosaccharide, guaiacol and syringol derivatives, contribute 7%–17%. Notably, crop straw and wood burning emit a higher abundance of guaiacol than syringol derivatives by a factor of 5. Additionally, a variety of nitrogen‐containing compounds (mainly in the CHON group) is identified, including isocyanate, amide, amino acids, and pyridine. The mass spectral profiles of organic compounds are largely similar between crop straw and wood burning fuels, although wood burning produces higher contributions of compounds with carbon atoms numbers >10. The saturation concentrations of organic compounds are estimated using molecular formula‐based volatility parameterization, revealing that semi‐volatile and intermediate VOCs (S/intermediate volatility organic compounds (IVOCs)) predominate smoke releases by 35%–60% and 20%–43%, respectively, with only a small fraction of low‐volatility compounds. Given the widespread nature of biomass burning in winter China, our results may have significant implications for interpreting secondary organic aerosol formation through gas‐particle partitioning or aqueous‐phase reactions.
Biocomposite thermoplastic polyurethanes containing evolved bacterial spores as living fillers to facilitate polymer disintegration
Authors: Kim Han Sol , Noh Myung Hyun , White Evan M. , Kandefer Michael V. , Wright Austin F. , Datta Debika , Lim Hyun Gyu , Smiggs Ethan , Locklin Jason J. , Rahman Md Arifur , Feist Adam M. , Pokorski Jonathan K. 
Published: April 2024

AbstractThe field of hybrid engineered living materials seeks to pair living organisms with synthetic materials to generate biocomposite materials with augmented function since living systems can provide highly-programmable and complex behavior. Engineered living materials have typically been fabricated using techniques in benign aqueous environments, limiting their application. In this work, biocomposite fabrication is demonstrated in which spores from polymer-degrading bacteria are incorporated into a thermoplastic polyurethane using high-temperature melt extrusion. Bacteria are engineered using adaptive laboratory evolution to improve their heat tolerance to ensure nearly complete cell survivability during manufacturing at 135 °C. Furthermore, the overall tensile properties of spore-filled thermoplastic polyurethanes are substantially improved, resulting in a significant improvement in toughness. The biocomposites facilitate disintegration in compost in the absence of a microbe-rich environment. Finally, embedded spores demonstrate a rationally programmed function, expressing green fluorescent protein. This research provides a scalable method to fabricate advanced biocomposite materials in industrially-compatible processes.
Cost-effectiveness and cost-utility of a digital technology-driven hierarchical healthcare screening pattern in China
Authors: Wu Xiaohang , Wu Yuxuan , Tu Zhenjun , Cao Zizheng , Xu Miaohong , Xiang Yifan , Lin Duoru , Jin Ling , Zhao Lanqin , Zhang Yingzhe , Liu Yu , Yan Pisong , Hu Weiling , Liu Jiali , Liu Lixue , Wang Xun , Wang Ruixin , Chen Jieying , Xiao Wei , Shang Yuanjun , Xie Peichen , Wang Dongni , Zhang Xulin , Dongye Meimei , Wang Chenxinqi , Ting Daniel Shu Wei , Liu Yizhi , Pan Rong , Lin Haotian 
Published: April 2024

AbstractUtilization of digital technologies for cataract screening in primary care is a potential solution for addressing the dilemma between the growing aging population and unequally distributed resources. Here, we propose a digital technology-driven hierarchical screening (DH screening) pattern implemented in China to promote the equity and accessibility of healthcare. It consists of home-based mobile artificial intelligence (AI) screening, community-based AI diagnosis, and referral to hospitals. We utilize decision-analytic Markov models to evaluate the cost-effectiveness and cost-utility of different cataract screening strategies (no screening, telescreening, AI screening and DH screening). A simulated cohort of 100,000 individuals from age 50 is built through a total of 30 1-year Markov cycles. The primary outcomes are incremental cost-effectiveness ratio and incremental cost-utility ratio. The results show that DH screening dominates no screening, telescreening and AI screening in urban and rural China. Annual DH screening emerges as the most economically effective strategy with 341 (338 to 344) and 1326 (1312 to 1340) years of blindness avoided compared with telescreening, and 37 (35 to 39) and 140 (131 to 148) years compared with AI screening in urban and rural settings, respectively. The findings remain robust across all sensitivity analyses conducted. Here, we report that DH screening is cost-effective in urban and rural China, and the annual screening proves to be the most cost-effective option, providing an economic rationale for policymakers promoting public eye health in low- and middle-income countries.
Stress during pubertal development affects female sociosexual behavior in mice
Authors: Bentefour Yassine , Bakker Julie 
Published: April 2024

AbstractPuberty is a crucial phase for the development of female sexual behavior. Growing evidence suggests that stress during this period may interfere with the development of sexual behavior. However, the neural circuits involved in this alteration remain elusive. Here, we demonstrated in mice that pubertal stress permanently disrupted sexual performance without affecting sexual preference. This was associated with a reduced expression and activation of neuronal nitric oxide synthase (nNOS) in the ventrolateral part of the ventromedial hypothalamus (VMHvl). Fiber photometry revealed that VMHvl nNOS neurons are strongly responsive to male olfactory cues with this activation being substantially reduced in pubertally stressed females. Finally, treatment with a NO donor partially restored sexual performance in pubertally stressed females. This study provides insights into the involvement of VMHvl nNOS in the processing of olfactory cues important for the expression of female sexual behavior. In addition, exposure to stress during puberty disrupts the integration of male olfactory cues leading to reduced sexual behavior.
The gene “degrees of kevin bacon” (dokb) regulates a social network behaviour in Drosophila melanogaster
Authors: Rooke Rebecca , Krupp Joshua J. , Rasool Amara , Golemiec Mireille , Stewart Megan , Schneider Jonathan , Levine Joel D. 
Published: April 2024

AbstractSocial networks are a mathematical representation of interactions among individuals which are prevalent across various animal species. Studies of human populations have shown the breadth of what can spread throughout a social network: obesity, smoking cessation, happiness, drug use and divorce. ‘Betweenness centrality’ is a key property of social networks that indicates an individual’s importance in facilitating communication and cohesion within the network. Heritability of betweenness centrality has been suggested in several species, however the genetic regulation of this property remains enigmatic. Here, we demonstrate that the gene CG14109, referred to as degrees of kevin bacon (dokb), influences betweenness centrality in Drosophila melanogaster. We identify strain-specific alleles of dokb with distinct amino acid sequences and when the dokb allele is exchanged between strains, flies exhibit the betweenness centrality pattern dictated by the donor allele. By inserting a GAL4 reporter into the dokb locus, we confirm that dokb is expressed in the central nervous system. These findings define a novel genetic entry point to study social network structure and thereby establish gene-to-social structure relationships. While dokb sequence homology is exclusive to Diptera, we anticipate that dokb-associated molecular pathways could unveil convergent neural mechanisms of social behaviour that apply in diverse animal species.
Identifying tumor type and cell type-specific gene expression alterations in pediatric central nervous system tumors
Authors: Lee Min Kyung , Azizgolshani Nasim , Shapiro Joshua A. , Nguyen Lananh N. , Kolling Fred W. , Zanazzi George J. , Frost Hildreth Robert , Christensen Brock C. 
Published: April 2024

AbstractCentral nervous system (CNS) tumors are the leading cause of pediatric cancer death, and these patients have an increased risk for developing secondary neoplasms. Due to the low prevalence of pediatric CNS tumors, major advances in targeted therapies have been lagging compared to other adult tumors. We collect single nuclei RNA-seq data from 84,700 nuclei of 35 pediatric CNS tumors and three non-tumoral pediatric brain tissues and characterize tumor heterogeneity and transcriptomic alterations. We distinguish cell subpopulations associated with specific tumor types including radial glial cells in ependymomas and oligodendrocyte precursor cells in astrocytomas. In tumors, we observe pathways important in neural stem cell-like populations, a cell type previously associated with therapy resistance. Lastly, we identify transcriptomic alterations among pediatric CNS tumor types compared to non-tumor tissues, while accounting for cell type effects on gene expression. Our results suggest potential tumor type and cell type-specific targets for pediatric CNS tumor treatment. Here we address current gaps in understanding single nuclei gene expression profiles of previously under-investigated tumor types and enhance current knowledge of gene expression profiles of single cells of various pediatric CNS tumors.