bluuebunny/crossref_metadata_2025_split huggingface dataset:
Height, weight, body mass index and pubertal development references for children of Moroccan origin in The Netherlands
Authors: Fredriks AM , van Buuren S , Jeurissen SER , Dekker FW , Verloove‐Vanhorick SP , Wit JM 
Published: August 2010

Aim: To provide growth and sexual maturation reference data for Moroccan children living in The Netherlands and to compare them with the reference data of children of Dutch origin. Methods: Cross‐sectional growth and demographic data were collected from 2880 children of Moroccan origin and 14 500 children of Dutch origin living in The Netherlands in the age range 0–20 y. Growth references for length, height, weight, weight‐for‐height, body mass index (BMI) and head circumference were constructed with the LMS method. Predictive variables for height and BMI were assessed by regression analyses. Reference curves for sexual maturation were estimated by a generalized additive model. Results: Moroccan young adults were on average 9 cm shorter than their Dutch contemporaries. Mean final height was 174.7 cm for males and 161.3 cm for females. Height differences in comparison with Dutch children increase from 2 y onwards. Height SDS was predominantly associated with target height. Compared to Dutch children, maturation started 0.2 and 0.9 y later for girls and boys, respectively. Median age at menarche was 12.9 y, 3.6 mo earlier than in Dutch girls (p= 0.001). BMI of Moroccan children was above that of Dutch children, especially for girls. BMI SDS was associated with birthweight in the age group 0–±5 y.Conclusion: Moroccan children living in The Netherlands are substantially shorter than Dutch children. Girls have higher weight‐for‐height and BMI for age. Median age at menarche occurs earlier. Given these differences, separate growth charts for the Moroccan children are useful.
Successful use of recombinant factor VIIa for management of severe menorrhagia in an adolescent with an acquired inhibitor of human thrombin
Authors: Giovannini L , Appert A , Monpoux F , Fischer F , Boutte P , Sirvent N 
Published: August 2010

Antibodies directed against human thrombin are exceedingly rare, having only been reported in adult patients with underlying diseases. Consensus on the most appropriate management has not yet been reached. A 12‐y‐old girl presented with intractable menorrhagia several days after an acute infectious episode. Laboratory tests revealed disturbed clotting tests: prothrombin index 17%, activated partial thromboplastin time >150 s, thrombin time >120 s, and failure to achieve correction with a normal pooled plasma. Further studies demonstrated the presence of an antibody directed against human thrombin. Viral serology revealed a 1/128 titre for adenovirus. Massive haemorrhage was unresponsive to standard treatments, but intravenous administration of recombinant factor VIIa resulted in a successful outcome.Conclusion: This is the first report of an anti‐human thrombin antibody associated with severe bleeding in a child. Recombinant factor VIIa could represent a novel therapeutic approach for such patients.
Giant congenital melanocytic naevus in association with hepatic melanin deposits
Authors: Prais D , Nussinovitch M , Kornreich L , Amir J 
Published: August 2010

AbstractThis report describes a neonate with a giant congenital pigmented naevus over most of the trunk surface area, along with multiple satellite lesions, especially over the legs. Magnetic resonance imaging of the abdomen showed large deposits of melanin in the glutei bilaterally, the rectus abdominis muscles and the liver. Treatment consisted of repeated dermabrasion of the naevus over the lower back with CO2 laser (Silk Touch), followed by autologous skin grafting. No evidence of malignant transformation was observed. Conclusion: Giant congenital melanocytic naevus may be associated with involvement of internal organs other than the central nervous system.
Developmental data in preschool children born after prolonged pregnancy
Authors: Lindström Katarina , Fernell Elisabeth , Westgren Magnus 
Published: August 2010

Abstract Aim: To evaluate children born post‐term (gestational age 42 weeks) with respect to developmental data obtained at the ages of 4 and 5.5 y. Methods: The study population included all children (n=354) born in 1991 at Huddinge University Hospital with a gestational age of 42 wk. The births were identified and perinatal data were collected through the Swedish National Birth Registry. Developmental assessments from the child health centres were analysed. Children born at term, but before a gestational age of 42 wk, served as controls. Logistic regression analysis was used to analyse the data. Results: Children born post‐term had more developmental deviations than the controls (estimated odds ratio 2.20; 95% CI: 1.29–3.85). Boys had more deviations than girls (estimated odds ratio 1.92; 95% CI: 1.11–3.45). Conclusion: Our results indicate that there might be an association between post‐term birth and developmental deviations.
Acute severe spinal cord dysfunction in a child with meningitis: Streptococcus pneumoniae and Mycoplasma pneumoniae co‐infection
Authors: Manteau Celine , Liet Jean Michel , Caillon Jocelyne , M'guyen Sylvie , Quere Marie Pierre , Roze Jean Christophe , Gras‐Le Guen Christèle 
Published: August 2010

AbstractTetraplegia developed abruptly in an 11‐y‐old with pneumococcal meningitis. Magnetic resonance imaging showed multiple hyperintensities at the brainstem–spinal cord junction. Serological tests were positive for Mycoplasma pneumoniae (microparticle agglutination and specific IgMs). Erythromycin and dexamethasone were started promptly, and 10 d later the patient was discharged with normal neurological function. Conclusion: Tetraplegia during the course of pneumococcal meningitis in an 11‐y‐old girl disappeared after treatment with ceftriaxone, erythromycin and dexamethasone.
Body composition measurements: From the past to the future
Authors: Pietrobelli Angelo , Tatò Luciano 
Published: August 2010

AbstractDuring growth, the human body increases in size and changes its proportions of various components due to hormone mediators. Growth is a complex, biological process regulated by multiple factors. These factors include genetics, nutritional intake, physical activity, age, gender and endocrine balance, all of which influence a child's body composition during the growth years. Quantifying the main components is integral to the study of growth, as the assessment of human physical characteristics is important both in the anthropological and medical fields. It is important to have the possibility to control the growth process and to predict adult status in order to reduce the risk factors of various diseases. Conclusion: This paper examines issues in the measurements of paediatric body composition, describing traditional and new tools in this field.
Diagnosis and early management of inborn errors of metabolism presenting around the time of birth
Authors: Leonard James V. , Morris Andrew A. M. 
Published: August 2010

AbstractInherited metabolic diseases often present around the time of birth. They are responsible for some cases of hydrops fetalis and a number of dysmorphic syndromes. Patients with inborn errors may also present at (or shortly after) birth with seizures or severe hypotonia. Most affected babies, however, appear normal at birth and subsequently deteriorate, with hypoglycaemia, acidosis, neurological or cardiac problems, or liver disease. Treatment often involves measures to reduce catabolism and to remove toxic metabolites. It should not be delayed for a definitive diagnosis. Conclusion: In the newborn period, inborn errors can easily be misdiagnosed as sepsis or birth asphyxia; prompt detection requires vigilance and the early measurement of biochemical markers, such as plasma ammonia.
Acute pancreatitis in paediatric systemic lupus erythematosus
Authors: Perrin Laurence , Giurgea Irina , Baudet‐Bonneville Valérie , Deschênes Georges , Bensman Albert , Ulinski Tim 
Published: August 2010

AbstractAcute pancreatitis (AP) rarely complicates the clinical course of systemic lupus erythematosus (SLE). AP as the initial manifestation of SLE is exceptional, but its outcome is often fatal. Corticosteroids have been suspected to play a role in the development of AP, but the therapeutic benefit seems to be far above the risk of exacerbation of pancreatic lesions. We report a 13‐y‐old girl presenting with arthralgia and malaise, followed by abdominal pain, generalized oedema and haemodynamic instability. Increased CRP (325 ng/ml), serum amylase (14 000 IU/l) and lipase (2500 IU/l) levels suggested AP. Acute anuric renal failure required haemodialysis. Multiorgan involvement suggested SLE, which was confirmed 3 d later by increased anti‐ds‐DNA levels. Three methylprednisolone pulses were administered promptly, followed by oral prednisone (1.5 mg/kg/d) and six pulses of cyclophosphamide (500 mg/1.73 m2/2 wk). Mycophenolate mofetil was introduced for long‐term disease control. Amylase and lipase levels decreased over 4 wk. Renal function was normal after 3 wk and proteinuria negative after 6 wk.Conclusion:This case suggests that steroid pulse therapy should be promptly administered if clinical and biochemical investigations suggest SLE to be responsible for AP. Aggressive treatment may be life saving.
Magnetic resonance imaging changes in Fabry disease
Authors: Ginsberg Lionel , Manara Renzo , Valentine Alan R. , Kendall Brian , Burlina Alessandro P. 
Published: August 2010

AbstractRecognized magnetic resonance imaging (MRI) abnormalities in the brains of patients with Fabry disease include the consequences of infarction and haemorrhage, non‐specific white and grey matter lesions, vascular anomalies, in particular dolicho‐ectasia, and a characteristic appearance of the posterior thalamus. A preliminary analysis of MRI findings in patients registered in FOS, the Fabry Outcome Survey, indicates that most patients had abnormal scans (25/47). The commonest abnormality, in males and females, was the presence of cerebral white matter lesions, the number of which increased with patient age. Conclusion: MRI is a valuable resource for assessing the CNS complications of Fabry disease, and their response to time and treatment.
Reversibility of cellular and organ pathology in enzyme replacement trials in animal models of lysosomal storage diseases
Authors: Gieselmann Volkmar 
Published: August 2010

AbstractEnzyme replacement therapy (ERT) has now become a feasible treatment option for several lysosomal storage diseases (LSDs). Although the rationale behind this approach is straightforward, there are many factors that may influence the efficacy of treatment. The reversibility of cellular and organ pathology depends on several factors including the particular organ targeted, the dose and biodistribution of enzyme, the accessibility of the target cell to the infused enzyme, the abundance of receptors for mannose‐6‐phosphate and other ligands in the target tissue and the activity of endocytosis. In addition, each lysosomal enzyme is unique and its ability to reverse pathology must be individually determined according to source, glycosylation and phosphorylation status. The extent to which cellular pathology may be corrected depends upon the delivery of sufficient enzyme to the diseased tissues. Conclusion: Studies in animal models have identified numerous factors that influence the therapeutic efficacy of ERT. This would suggest that in patients affected by LSDs rigorous evaluation of each therapeutic preparation will be needed.
Sexual Function in a Woman with Congenital Bladder Exstrophy and Multiple Pelvic Reconstructive Surgeries: A Case Report
Authors: Vaccaro Christine M. , Herfel Chuck , Karram Mickey M. , Pauls Rachel N. 
Published: August 2010

ABSTRACT

Introduction
Bladder exstrophy is a rare congenital anomaly isolated to the fetal genitourinary tract. In our patient, this defect necessitated removal of her bladder in her childhood and a distal neovaginoplasty in adolescence. Despite these surgeries, as well as several procedures for pelvic organ prolapse, the patient reports excellent sexual function and ability to achieve vaginal orgasms.

Aim
(i) To report on the sexual function of a woman without a bladder or urethra who has undergone multiple pelvic reconstructive surgeries; and (ii) to correlate her self-reported erotic areas with magnetic resonance imaging (MRI) assessment.

Methods
The patient completed a detailed sexual history, the Female Sexual Function Index (FSFI), the Female Sexual Distress Scale (FSDS), the Pelvic Organ Prolapse/Urinary Incontinence Sexual Function Questionnaire (PISQ-12), and the Health Survey Short Form (SF-12). Photodocumentation of her erotic tissue was correlated with a pelvic MRI with contrast.

Results
The patient reports ability to achieve vaginal orgasms 100% of the time. Her FSFI score was 29.4/36 with maximum scores noted in arousal, lubrication, orgasm and satisfaction. Her FSDS score was 7/48, which implies no sexually related distress. Her PISQ-12 score was 10/48, demonstrating a small impact on her sexual function related to her pelvic organ prolapse. Her SF-12 scores were 36.6 and 57.9. Photography and mapping of her erotic areas illustrated the superficial and anterior locations of the vaginal opening to be the sites of orgasm. MRI correlated these exact locations with clitoral tissue.

Conclusion
Intact sexual function is possible in patients after reconstructive surgery for congenital bladder exstrophy. Due to the superficial location of her clitoris and separation of the pubic rami associated with this anatomic variant, sexual function may be enhanced.
The Effects of Climatic Variability on Estimates of Recharge from Temperature Profiles
Authors: Ferguson Grant , Woodbury Allan D. 
Published: August 2010

AbstractUsing heat as a tracer allows for estimation of ground water recharge rates based on subsurface temperature measurements. While possible in theory, it may be difficult in practice to discriminate the effects of climate from the effects of ground water advection. This study uses synthetic simulations to determine the influence of variability of ground surface temperature (GST) on the ability to estimate vertical specific discharge from temperature profiles. Results suggest that in cases where temperature measurements are sufficiently deep and specific discharge is sufficiently high, estimates of specific discharges will be reasonably accurate. Increasing the number of times temperatures are measured, or producing models that incorporate variations in GST, will increase the reliability of any studies using temperatures to estimate specific discharge. Furthermore, inversions of temperature measurements should be combined with other methods of estimating recharge rates to improve the reliability of recharge estimates.
Modeling Effects of Multinode Wells on Solute Transport
Authors: Konikow Leonard F. , Hornberger George Z. 
Published: August 2010

AbstractLong‐screen wells or long open boreholes with intraborehole flow potentially provide pathways for contaminants to move from one location to another in a ground water flow system. Such wells also can perturb a flow field so that the well will not provide water samples that are representative of ground water quality a short distance away from the well. A methodology is presented to accurately and efficiently simulate solute transport in ground water systems that include wells longer than the grid spacing used in a simulation model of the system and hence are connected to multiple nodes of the grid. The methods are implemented in a MODFLOW‐compatible solute‐transport model and use MODFLOW’s Multi‐Node Well Package but are generic and can be readily implemented in other solute‐transport models. For nonpumping multinode wells (used to simulate open boreholes or observation wells, for example) and for low‐rate pumping wells (in which the flow between the well and the ground water system is not unidirectional), a simple routing and local mixing model was developed to calculate nodal concentrations within the borehole. For high‐rate pumping multinode wells (either withdrawal or injection, in which flow between the well and the ground water system is in the same direction at all well nodes), complete and instantaneous mixing in the wellbore of all inflows is assumed.
Identification of application‐specific critical inputs for the 1991 Johnson and Ettinger vapor intrusion algorithm
Authors: Johnson Paul C. 
Published: August 2010

AbstractAt sites where soil or ground water contains chemicals of concern, there is the potential for chemical vapors to migrate through the subsurface to nearby basements, buildings, and other enclosed spaces. The 1991 Johnson and Ettinger algorithm and subsequent refinements are often used to assess the significance of this pathway and to establish target cleanup levels. To facilitate its use, the U.S. EPA distributes spreadsheets programmed with the 1991 Johnson and Ettinger algorithm. These user‐friendly spreadsheets make the equations more accessible; however, the U.S. EPA spreadsheets require a large number of inputs (>20), and as a result, relationships between model inputs and outputs are not well understood and users are not able to identify and focus on the critical inputs. The U.S. EPA spreadsheets also allow users to inadvertently enter inconsistent and unreasonable sets of input values, and these often lead to unreasonable outputs. The objective of this work, therefore, is to help users develop a better understanding of the relationships between inputs and outputs so that they can identify critical inputs and also to ensure reasonableness of inputs and outputs. The 1991 Johnson and Ettinger algorithm is introduced, and differences between it and its U.S. EPA spreadsheet implementation are identified. Next, results from a parametric analysis of the algorithm are used to create a flowchart‐based approach for identifying the application‐specific critical inputs. Use of the flowchart‐based approach is then illustrated and validated through comparison with the results of a more traditional sensitivity analysis for four scenarios. Recommendations are also given for the reformulation of inputs to minimize misapplication of the algorithm and the spreadsheets, and reasonable ranges for reformulated input values are discussed.
Automated ground water sampling and analysis of trichloroethene using a “universal” sampling/analytical system
Authors: Burge Scott R. , May James 
Published: August 2010

AbstractLong‐term monitoring of sites contaminated with recalcitrant compounds will require the deployment of analytical sensors in an automated system capable of some degree of calibration and quality control. The primary method of providing calibration is to enclose the analytical sensors in a chamber where the environment of the chamber may be controlled. An automated “universal” sampling/calibration/analytical system was developed for mounting analytical sensors in the well or adjacent to the well. The automated universal system allows a sensor to directly analyze the analyte in the water sample or to analyze the analyte in the headspace above the water sample. The ability to analyze the analyte partitioned into the headspace is important for the determination of many volatile species. The analysis of trichloroethene (TCE) is performed by a TCE optrode monitoring the TCE concentrations in the headspace above the water sample. The term optrode refers to a chemically selective fiber‐optic sensor. The TCE in the headspace reacts with a colorimetric reagent, producing a colored (red) product. The time history of the development of the colored product is used as the method of determination. The TCE optrode has a limit of detection of 1 part per billion (ppb). There are no interferences from many commonly occurring volatile chlorinated compounds encountered in aquifers such as tetrachloroethene, dichloroethenes, trichloroethane, or dichloroethanes. The system was deployed for monitoring TCE concentrations up to 200 ppb at sites in California and Florida.
A New Leak Detection System for Long‐Distance Pipelines Utilizing Soil‐Gas Techniques
Authors: Liang K.F. , Kuo M.C. Tom 
Published: August 2010

AbstractThis paper presents a new leak detection system for a long‐distance pipeline using soil‐gas techniques. The new leak detection system runs underground along the nearby pipeline and consists of intermittent porous tubes connected in series with impermeable polyethylene tubes. Applying the new detection system to long‐distance pipelines for leak detection minimizes the large number of soil‐gas samples and analyses that are required when conventional soil‐gas probes are employed. A mathematical model was developed for designing the distribution of airflow in the new detection system. Field leak tests were conducted using both conventional soil‐gas probes and the new system. Results indicated that the effective detection distance of the new system was at least 30 m, while the effective detection radius from the conventional soil‐gas probes is only ∼5 m.
Simultaneous Gamma Prediction Limits for Ground Water Monitoring Applications
Authors: Gibbons Robert D. , Bhaumik Dulal K. 
Published: August 2010

AbstractCommon problems in the analysis of environmental monitoring data are nonnormal distributions (i.e., right skewed such as gamma and lognormal) and the presence of moderate to large numbers of nondetects (i.e., data below a detection or quantification limit). When new monitoring measurements are compared to background (e.g., comparison of a new downgradient ground water measurement to a series of background or upgradient ground water monitoring measurements), prediction intervals are often the statistical method of choice. A limitation of the usual application of normal prediction limits in the analysis of environmental data is the assumption of normality, which is often violated by both extreme concentrations (in background) and the presence of censored data (i.e., nondetects). While nonparametric alternatives are available, they often require larger numbers of background samples than are typically available in routine practice. This paper extends the literature on normal and nonparametric simultaneous prediction intervals to the case of the gamma distribution, which can accommodate a wide variety of nonnormal distributions (with skewed right tails) and the presence of nondetects. Gamma prediction limits are excellent candidates for routine application to ground water monitoring networks at waste disposal facilities and/or other relevant environmental monitoring applications. The method is illustrated using example ground water detection monitoring data. The paper includes a series of tables that can be used for routine application of the statistical methodology.
International Intellectual Property Dispute Resolution
Authors: Fernandez Carmen Collar , Spolter Jerry 
Published: August 2010

“In a micro‐electronic patent or a computer software copyright dispute, litigation or arbitration can take longer than the life‐cycle of the product concerned; a preliminary injunction can kill an entire product line, and a damage award will invariably come too late, at a time when the victim may have already been ruined.”Christian Bürhring‐Uhle1