bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Obligation of Notary as a Reporter in Efforts to Prevent and Eradicate Money Laundering Crime
Authors: Tejakusuma Erwin Kunta , Nurhayati Dwi Endah , Samosir Samuel Saut Martua 
Published: May 2024

Money laundering is a structured and diverse crime, the implementation of which can utilize financial institutions and institutions outside the financial system. In Government Regulation No. 43/2015 on Reporting Parties in the Prevention and Eradication of ML, it is stated that notary is one of the reporting parties. However, this obligation to report conflicts with the obligation to keep the contents of the deed and all information regarding the deed confidential as stipulated in the Notary Position Law. Notaries in carrying out their duties are bound by an oath of office that they must uphold. One of the notary oaths is regarding notary confidentiality as written in Article 4 Paragraph (2) of Law Number 30 Year 2004. In addition, notaries in carrying out their positions, based on Article 16 of UUJN Paragraph (1) letter f, notaries are obliged to "keep confidential everything regarding the deed they make and all information obtained for the making of the deed in accordance with their oath / pledge of office, unless the law determines otherwise". The clash of norms between private law and public law certainly requires legal protection in carrying out their positions. The legal protection applied is related to the guarantee of the rights and obligations of notaries, both regarding their obligations as reporting parties in efforts to prevent and eradicate money laundering crimes and notary obligations in the realm of private law. This legal protection is intended so that notaries can be free from claims or lawsuits in carrying out their obligations as reporting parties in efforts to prevent and eradicate money laundering crimes.
KEYWORDS : Notary, Obligations of the Reporting Party, Legal Protection.
IT SERVICE MANAGEMENT FOR BUSINESS PROCESS OF STAFF ARCHIVE DIGITALIZATION USING ITIL 3TH VERSION FRAMEWORK (CASE STUDY: BKPP OF SEMARANG CITY)
Authors: Yupie Kusumawati  , Hanin Anggia Rizkika , Ningrum Novita Kurnia , Mulyono Ibnu Utomo Wahyu , Susanto Ajib , Widyatmoko Karis 
Published: May 2024

The role of archivist in an agency is as needed as in the Badan Kepegawaian, Pendidikan dan Pelatihan Kota Semarang (BKPP of semarang).Badan Kepegawaian, Pendidikan dan Pelatihan Kota Semarang currently has digitized archive services Employment is e-file service. The problem we found today is service the e-file is only used as a data archive and has not yet supported the business process resources. Another problem found on e-file services is not yet available service contact and lack of human resources. To support the business process then this research will design the management of it services on digitalization of employment archives. On this rre-design, e-file services will be linked to other IT services such as SISDM and E-Fungsional. This research uses the framework ITIL 3th Version domain service design with the sub domain service design package and service catalogue for document creation of the entire sequence of design. On this research there are also multiple support services like a service in contact, hours level services, risk identification, enhanced resources and structures the organization proposal so that current e-file services can support business processes digitalization of employment archives on the BKPP Kota Semarang
Canopy Architecture and Sun Exposure Influence Berry Cluster Water Relations in Grapevine
Authors: Zarrouk Olfa , Pinto Clara , Alarcón Maria Victoria , Flores-Roco Alicia , Santos Leonardo , Soares-David Teresa , Amancio Sara , Lopes Carlos M , Carvalho Luisa C 
Published: May 2024

Climate change related increases in frequency and intensity of heatwaves affect viticulture, leading to losses in yield and grape quality. We assessed whether canopy architecture manipulation mitigates the effects of summer stress in a Mediterranean vineyard. Muscat of Alexandria grapevines were monitored during 2019-2020. Two canopy shoot positioning treatments were applied: Vertical shoot positioning (VSP); and Modulated shoot positioning (MSP), the west side upper foliage released to promote partial shoot leaning, shading the clusters. Clusters were sampled at pea size (PS), veraison (VER) and full maturation (FM). Measurements included rachis anatomy and hydraulic conductance, and aquaporins (AQP) and stress-related genes expression in cluster tissues. Results show significant seasonal and interannual differences in Kh and vascular anatomy. At VER, Krachis , Krachis+pedicels, and xylem diameter decreased but were unaffected by treatments. The Phloem/Xylem ratio was either increased (2019) or reduced (2020) in MSP, compared to VSP. Most AQP were down-regulated at FM in pedicels, and up-regulated at VER in pulp. A potential maturation shift in MSP was observed, confirmed by the up-regulation of several stress-related genes in all tissues. The study pinpoints the role of canopy architecture in berry water relations and stress response during ripening.
Dimensional Accuracy and Mechanical Characterization of Inconel 625 components in Atomic Diffusion Additive Manufacturing
Authors: Rosnitschek Tobias , Stierle Catharina , Orgeldinger Christian , Seynstahl Armin , Alber-Laukant Bettina , Tremmel Stephan 
Published: May 2024

Additive manufacturing processes offer various options to fabricate metal parts, which show numerous ecological and technological advantages compared to formative and subtractive manufacturing methods. Due to quick availability and high accuracy, they are particularly suitable to produce complex prototypes. Metal fused deposition modeling is a relatively new material extrusion additive manufacturing technique based on the widely used fused filament deposition process. This study focuses on the Inconel 625 metal filament from Markforged Inc., it consists of a mixture of metal powder and a binder system, the latter being removed during washing and sintering. In this article, the mechanical properties of printed and sintered Inconel were investigated using tensile testing specimens with three different infill patterns, solid, triangular, and gyroid, printed in flatwise and upright direction. In addition, investigations into the dimensional accuracy of the printed specimens and the sintering shrinkage were carried out. The results showed that neither the dimensional accuracy nor the sintering shrinkage was significantly influenced by the printing orientation. In the context of lightweight engineering, the structures proofed beneficial especially within the elastic region. Generally, triangular infill patterns resulted in higher stiffness, while gyroids led to more ductile specimens. A mass-related evaluation of tensile testing elucidates that with aid of the infill structures weight savings of 40 % resulted in mechanical performance decreased by only 20 % on average.
Politik Kesejahteraan Sosial dan Pemberdayaan Masyarakat: Kasus Ketergantungan Kebijakan Bantuan Sosial di Temanggung, Jawa Tengah
Authors: Sugiastuti Nursari , Ulinnuha Roma 
Published: May 2024

<p>One of the government's strategies for overcoming poverty is to reduce the burden of public expenditure, which is realized in the form of social assistance. The government's social welfare policy in the form of social assistance is something that is truly phenomenal and is always eagerly awaited by the recipients. One of the effects is to provide a sense of security and feel like you are in a comfort zone, in other words, dependence on social assistance. But there are beneficiaries who are dissatisfied with their situation, they want positive changes and not to be recipients of social assistance forever. They made conscious changes by empowering their group of fellow recipients of the Family Hope Program's social assistance. This research is field research in the form of a case study located in Temanggung Regency with the research object being a Joint Business Group which carries out the establishment and initial capital independently, namely from the results of setting aside some of the social assistance money they receive. The research method used is a qualitative descriptive method, while data is obtained from observations, interviews and documentation studies from related sources. This article tries to review the theme with Anthony Giddens' structuration theory, which states that all social action requires agents and structures where agents and structures cannot be separated from each other because they are dual. This also happens to Joint Business Groups as agents and government policies as structures, both of which are interrelated and influence each other.</p><p> </p>
Automated Reservoir Characterization of Carbonate Rocks using Deep Learning Image Segmentation Approach
Authors: Nande Soumitra B. , Patwardhan Samarth D. 
Published: May 2024

Summary
The objective of this study is to develop a systematic and novel workflow for the automated and objective characterization of carbonate reservoirs with the help of deep learning architectures. An image database of more than 6,000 carbonate thin-section images was generated using the optical microscope and image augmentation techniques. Five features, namely clay/silt/mineral, calcite, pores, fossils, and opaque minerals, were identified with the help of manual petrography of the thin sections under the microscope. A total of four deep learning models were developed, which included U-Net, U-Net with ResNet34 backbone, U-Net with Mobilenetv2 backbone, and LinkNet with ResNet34 backbone. The Ensemble model of U-Net + ResNet34 and U-Net + MobileNetv2 yielded the highest intersection over union (IoU) score of 75%, followed by the U-Net + ResNet34 model with an IoU score of 61%. The models struggled with class imbalance, which was very prominent in the image database, with classes such as fossils and opaques considered to be rare. The statistical analysis of the relative errors revealed that the major classes play a more important role in increasing the final IoU score as opposed to the common understanding that the rare classes affect the model performance. The novel workflow developed in this paper can be extended to real carbonate reservoirs for time efficient, objective, and accurate characterization.
Design and rationale for an empirical investigation of the resource use and costs of investigator-initiated randomized trials in Switzerland, the United Kingdom, and Germany
Authors: Griessbach Alexandra , Speich Benjamin , Dutilh Gilles , Treweek Shaun , Schwenkglenks Matthias , Briel Matthias 
Published: May 2024

Abstract

Background
Conducting high-quality randomized clinical trials (RCTs) is challenging, time consuming and resource intense. Academic investigators usually depend on scarce financial resources, however, current literature lacks systematically collected empirical data on the detailed resource use and costs of investigator-initiated RCTs.
Methods
The aim of this study is to generate a database of detailed empirical resource use and cost data from 100 investigator-initiated RCTs in Switzerland, Germany, and the United Kingdom. Investigators enter their empirical costs data into an online case report form, which is followed by a short interview and a detailed cost report. We plan to investigate cost patterns and cost drivers, examine planned versus actual RCT costs as well as explore the heterogeneity of costs across the planning, conduct, and finalization phases, in drug and non-drug trials, and across medical fields and countries.
Discussion
This study will add detailed empirical data to the limited research on investigator-initiated RCT costs currently available. A study limitation will be that cost data will be retrospective and self-reported, which might be inaccurate depending on how costs were recorded.
Registration:
Open Science Framework (OSF) https://doi.org/10.17605/OSF.IO/QY2GU
Enhanced Complement Expression in the Tumor Microenvironment Following Neoadjuvant Therapy: Implications for Immunomodulation and Survival in Pancreatic Ductal Adenocarcinoma
Authors: Zhang Xiaofei , Lan Ruoxin , Liu Yongjun , Pillarisetty Venu , Li Danting , Zhao Chaohui , Sarkar Suparna , Liu Weiguo , Hanna Iman , Gupta Mala , Hajdu Cristina , Melamed Jonathan , Shusterma Michael , Widmer Jessica , Allendorf John , Liu Yao-zhong 
Published: May 2024

Abstract

Background Neoadjuvant therapy (NAT) is increasingly being used for pancreatic ductal adenocarcinoma (PDAC) treatment. However, its specific effects on carcinoma cells and the tumor microenvironment (TME) are not fully understood. This study aims to investigate how NAT differentially impacts PDAC’s carcinoma cells and TME.
Methods Spatial transcriptomics was used to compare gene expression profiles in carcinoma cells and the TME between 23 NAT-treated and 13 NAT-naïve PDAC patients, correlating with their clinicopathologic features. Analysis of an online single-nucleus RNA sequencing (snRNA-seq) dataset was performed for validation of the specific cell types responsible for NAT-induced gene expression alterations.
Results NAT not only induces apoptosis and inhibits proliferation in carcinoma cells but also significantly remodels the TME. Notably, NAT induces a coordinated upregulation of multiple key complement genes (C3, C1S, C1R, C4B and C7) in the TME, making the complement pathway one of the most significantly affected pathways by NAT. Patients with higher TME complement expression following NAT exhibit improved overall survival. These patients also exhibit increased immunomodulatory and neurotrophic cancer-associated fibroblasts (CAFs); more CD4+ T cells, monocytes, and mast cells; and reduced immune exhaustion gene expression. snRNA-seq analysis demonstrates C3 complement was specifically upregulated in CAFs but not in other stroma cell types.
Conclusions NAT can enhance complement production and signaling within the TME, which is associated with reduced immunosuppression in PDAC. These findings suggest that local complement dynamics could serve as a novel biomarker for prognosis, evaluating treatment response and resistance, and guiding therapeutic strategies in NAT-treated PDAC patients.
Paravalvular Abscess Causing Severe Aortic Insufficiency with Aorto-Right Ventricular Fistula
Authors: Kumanayaka Dilesha Dilangi , Ahmed Eyad , Chigurupati Himaja Dutt , Chow Priscilla , Sharma Hari , Khan Ahsan 
Published: May 2024

Abstract

This is a case report of a large paravalvular abscess of the aortic valve (AV) causing severe aortic insufficiency, complicated by aortic root to right ventricular fistula, in a young patient who admits to intravenous drug use (IVDU) and presented with skin abscesses and septic shock. Our case highlights the cruciality of early detection, diagnosis, and management of aorto-cavitary fistulas by echocardiography, due to high mobility and mortality associated.
Assessment of exposure for make-up cosmetic products in Shanghai
Authors: She Yuanyuan , Tang Yang , Chen Jian , Chen Tian , Cui Wenguang , Chen Yijun , Zhou Lihong , Li Zhu 
Published: May 2024

Abstract

Limited data exist on cosmetic exposure in China, especially for make-up cosmetic products. The objective of this study was to evaluate the daily exposure of 346 female make-up users in Shanghai to 10 make-up cosmetic products over a two-week period using an online daily questionnaire. The levels of exposure to non-powder base makeup, eye shadow and eyeliner, mascara, lip stick, and makeup remover were lower than the values currently used by the Scientific Committee on Consumer Safety (SCCS). The amount of applied per application of some categories was close to that of Japan and South Korea, but the amount of applied per day was lower. Therefore, it is urgent to establish exposure parameters for the local population in China. The exposure values obtained in this study for the Shanghai population will be useful for safety assessors and for safety agencies in order to protect both the general population and at-risk populations.
Prediction of low back fasciitis by machine learning method based on radiomics
Authors: song mingxin , Jiang ling , Yang hui , Jia cheng , Qin Jian , Xiao Qiang 
Published: May 2024

Abstract

Purpose: The aim of this study was to analyze lumbar fascial changes in patients with lower back pain using lumbar spine soft tissue-based MR imaging radiomics.
Methods: We retrospectively analyzed the lumbar MRI of 380 patients with low back pain. Patients were randomly assigned to either the training (n = 187) or validation (n = 193) cohorts. Seven different machine learning algorithms were used to establish classification prediction models, and their prediction efficiency were evaluated with the best performance was selected as the final classification prediction model. Multivariate logistic regression analysis was used to create radiomics model and combined nomogram model and their predictive performance were evaluated using receiver operating characteristic (ROC) curves.
Results:Among the seven machine learning models, the Lasso model exhibited the highest diagnostic efficiency with an AUC of 0.835. The radiomics nomogram integrated clinical and radiomics signature features, demonstrating strong performance in both the training and validation sets with AUC values of 0.97 and 0.96, respectively. AUC and DCA indicated that the radiomics nomogram model effectively diagnosed lumbar fasciitis.
Conclusion: We developed an nomogram model that integrated clinical and radiomics features to help clinicians identify and predict low back fasciitis through soft tissue magnetic resonance.
JAML overexpressed in colorectal cancer promotes tumour proliferation by activating the PI3K-AKT-mTOR signalling pathway
Authors: Fang Yuying , Liu Yanan , Dong Zhilin , Zhao Xinchao , Zhang Mingyan , Zheng Yawen , Yang Chunsheng , Wang Yufeng , Liu Ning , Yan Peng , Ma Yuan , Yang Fei , Zheng Yan , Zhang Wencheng , Yang Jianmin , Sun Meili 
Published: May 2024

Abstract

The expression and biological function of junctional adhesion molecule-like protein (JAML) in colorectal cancer (CRC) remain unclear. Paraffin tissue samples from 50 cases of CRC were collected to determine the expression of JAML. JAML was overexpressed or knock-down in CRC cells to evaluated the proliferation, migration and invasion in vitro and in vivo. Western-blot and others were applied to explore the mechanisms. The study showed that JAML was highly expressed within cancer tissues in 50% (25/50) of patients with CRC compared to adjacent tissues (p < 0.0001). Patients of JAML− high group had poorer overall survival compared to JAML− low group (p = 0.0362, HR = 0.4295, 95% CI of 0.1908–0.9667). The tumour infiltrating lymphocytes (TILs) was lower in the JAML− high group than in the JAML− low group (p < 0.05). Overexpression of JAML promoted the proliferation, migration, and invasion of CRC by activating the PI3K-AKT-mTOR signalling pathway both in vitro and in vivo. TILs were reduced in JAML− high tumour tissues by decreasing chemokines such as CCL20 and CXCL9/10/11. Our study identified JAML, a potentially ideal target that is specifically highly expressed in CRC tissues, which promoted tumour proliferation, impaired T-lymphocytes infiltration, provided a promising therapeutic strategy for patients with CRC.
X-ray Interferometry Using a Modulated Phase Grating: Theory and Experiments
Authors: Meyer Hunter , Dey Joyoni , Carr Sydney , Ham Kyungmin , Butler Leslie G. , Dooley Kerry M. , Hidrovo Ivan , Bleuel Markus , Varga Tamas , Schulz Joachim , Beckenbach Thomas , Kaiser Konradin 
Published: May 2024

Abstract

X-ray grating interferometry allows for the simultaneous acquisition of attenuation, differential-phase contrast, and dark-field images, resulting from X-ray attenuation, refraction, and small-angle scattering, respectively. The modulated phase grating (MPG) interferometer is a recently developed grating interferometry system capable of generating a directly resolvable interference pattern using a relatively large period grating envelope function that is sampled at a pitch that allows for X-ray spatial coherence using a microfocus X-ray source or by use of a source G0 grating that follows the Lau condition. We present the theory of the MPG inter-ferometry system for a 2-dimensional staggered grating, derived using Fourier optics, and we compare the theoretical predictions with experiments we have performed with a microfocus X-ray system at Pennington Biomedical Research Center, LSU. The theoretical and experimental fringe visibility is evaluated as a function of grating-to-detector distance. Quantitative experiments are performed with porous carbon and alumina samples, and qualitative analysis of attenuation and dark-field images of a dried anchovy are shown.
Is minimally invasive superior to traditional open technique for two-segmental transforaminal interbody fusion in the treatment of lumbar degenerative disease?
Authors: Wang Fei , Zhang SongOu , Zhou Ping , He Liu , Chen Kai , Zhou Xiaoyi , Zhao Xiaofeng , Xie Minghua , Che Bin , Lu Yanghu 
Published: May 2024

Abstract

Study Design: Retrospective case‒control study.
Purpose: To compare minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) and Traditional open TLIF in the treatment of two segments lumbar degenerative diseases.
Methods:Patients who underwent two-level MIS-TLIF (n = 222) and traditional open TLIF (n = 214) for lumbar degenerative disease. Demographic characteristics, surgical information, and perioperative complications were compared between the MIS-TLIF and Open TLIF groups. The Visual Analog Scale (VAS), Oswestry Disability Index (ODI) and 36-Item Short Form Survey Instrument (SF-36) were administered for clinical evaluations.
Results: Patients who underwent MIS-TLIF had a significantly lower volume of blood loss (176.2 ± 30.4mL vs 396.4 ± 59.7mL), lower postoperative drainage (102.6 ± 22.6 mL vs 164.4 ± 26.9mL), shorter bed rest time (3.3 d vs 4.7 d), longer operative time (201.4 ± 17.6 min vs 147.7 ± 16.0 min), and the higher fluoroscopy time (45.3 ± 6.3 seconds vs. 14.0 ± 2.3 seconds) than those who underwent Open TLIF. Significant clinical improvement was observed in terms of scores on the VAS, ODI, and SF-36 when comparing the preoperativeevaluation and the final follow-up. Postoperatively, both MIS-TLIF and open TLIF groups showed significant improvement in VAS, ODI, and SF-36 scores from 3 months to 2 years. VAS, ODI, and SF-36 scores were not different between MIS-TLIF and open TLIF groups after one year follow up. No significantly difference was found when comparing the complication rate between MI-TLIF and open TLIF groups.
Conclusions:Both MIS-TLIF and Open TLIF were effective approaches for the treatment of two-level lumbar degenerative diseases. Although MIS-TLIF procedure can improve health-related quality of life for patients better than open procedure after operation, there is no significant difference in this advantage after one year operation. We decided to choose MIS-TLIF or open TLIF procedure according to the physical condition of patients and surgeons’clinical experiences.