bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health‐related quality of life of adult and adolescent patients living with alopecia areata in Australia
Authors: Sinclair Rodney , Eisman Samantha , Lee Carol M. Y. , Hitschfeld Maureen , Witcombe David , Pereira Candida da Fonseca 
Published: May 2024

AbstractIntroductionTo understand the experiences of adolescent and adult patients living with alopecia areata (AA) in Australia regarding symptom severity and the impact on psychosocial well‐being and work/classroom productivity.Materials and MethodsA cross‐sectional online patient survey among adolescent and adult patients diagnosed with AA was recruited via the Australia Alopecia Areata Foundation. Patient‐reported outcomes were also assessed.ResultsA total of 337 patients (49 adolescents; 288 adults), with a mean ± standard deviation age of 14.7 ± 1.55 and 38.9 ± 13.31 years for adolescents and adults, respectively, were included. In the group with extensive hair loss (Scalp Hair Assessment Patient‐Reported Outcome, categories 3 + 4, n = 172), we observed higher emotional symptom and activity limitation scores (Alopecia Areata Patient Priority Outcomes, emotional symptoms: adults 2.5 ± 1.03, adolescents 2.2 ± 1.15; activity limitations: adults 1.4 ± 1.15, adolescents 1.2 ± 0.99). Additionally, in adults, the Alopecia Areata Symptom Impact Scale global score was 4.0 ± 2.10 (symptoms subscale score 4.1 ± 1.91; interference subscale scores 3.8 ± 2.73). Hospital Anxiety and Depression Scale scores were high across participants, irrespective of hair loss extent (adults: anxiety 9.2 ± 3.85, depression 6.6 ± 3.95; adolescents: anxiety 9.7 ± 4.65, depression 5.2 ± 3.59). Work and classroom productivity were substantially impaired due to AA, with 70.5% of adults and 57.1% of adolescents reporting activity impairment, and overall work/classroom impairment reported at 39.2% and 44.9%, respectively.ConclusionsAA impacts the physical, emotional and psychosocial well‐being of both adult and adolescent patients. More extensive hair loss more profoundly impacts those living with AA. Patients may benefit from patient‐centred care approaches addressing the impact of hair loss on mental and emotional well‐being, daily activities and work productivity.
Resistance against tree encroachment is driven by richness and identity of herbaceous resident species
Authors: Trejo‐Pérez Rolando , Chagnon Pierre‐Luc , Boivin Patrick , Brisson Jacques 
Published: May 2024

AbstractAimsHerbaceous plant cover can be used to inhibit tree encroachment in many managed and semi‐natural grasslands. Ideally, herbaceous seed mixtures should reduce the establishment and growth of many invading tree species over several years. Theory predicts that invasion resistance can be maximized by both: (a) increasing the diversity (taxonomic and/or functional) of resident seed mixtures, and (b) including species that are especially efficient at blocking further colonizers. We established an experiment in a regularly mown old field within a deciduous forest region in southeastern Canada. Our overall goal was to examine the relative contribution of old field community composition and diversity (taxonomic and functional) to resistance against encroachment by two undesirable native tree species over time.LocationVarennes, southern Québec, Canada (45°37′01.24″ N, 73°23′03.57″ W).MethodsWe tested our hypotheses by seeding experimental plots with different levels of taxonomic diversity (from one to nine species) and functional group richness (grasses, legumes, and forbs). Our herbaceous species comprised four native species and five introduced and naturalized species. We then seeded the plots with two model tree colonizers, Acer rubrum and Betula populifolia, during three consecutive years. We also transplanted seedlings of Acer and Betula to determine the effect of herbaceous diversity on post‐emergence growth and seedling survival.ResultsOverall, herbaceous species identity (presence and absence) better predicted the resistance of resident herbaceous seed mixtures to tree encroachment than the other diversity measures assessed in our study. Fast‐growing herbaceous species, such as Lolium, substantially inhibit resistance to woody encroachment in the first year. Achillea millefolium and Solidago canadensis were by far the most efficient in blocking tree seedling establishment and growth, particularly during the second and third years. These effects highlight the potential for a combination of fast‐growing species, along with slower‐growing but highly inhibitive species, as a way to limit tree encroachment in real field applications. Functional group richness was a poor predictor of tree encroachment. Species richness reduced tree encroachment, especially when considering a multidimensional tree encroachment index integrating all aspects of tree establishment and growth over the three years of our experiment.ConclusionsSeeding highly inhibiting herbaceous species is the most efficient approach against specific tree invaders. However, it is difficult to implement in practice because it relies on a priori knowledge of the species’ inhibitory effects. In the absence of this knowledge, the taxonomic richness of seed mixtures should be increased to prevent tree encroachment.
‘School‐based screen‐and‐treat’: An effective blueprint for expediating access to care in children experiencing PTSD following disasters
Authors: Cobham Vanessa E. , McDermott Brett 
Published: May 2024

AbstractObjectivesWhile 5%–10% of children exposed to natural disasters develop PTSD, few children access support. This paper reports on the proactive ‘screen‐and‐treat’ approach deployed following devastating floods in Queensland, Australia, in 2011 and presents results for children in the Lockyer Valley (the most impacted community).DesignOpen treatment study (2011–2012) within a government‐funded post‐disaster service response.MethodsOne hundred and fifty children (7–12 years) completed pencil‐and‐paper screening (PTSD, anxiety and depression) at school. Eighty children endorsing either clinical levels of PTSD, or moderate levels of PTSD and clinical levels of either anxiety or depression, and their parents, completed a structured diagnostic interview. Forty‐eight children were offered a free trauma‐focused CBT intervention. The parents of 19 children accepted this offer. Most clinicians were clinical psychology trainees from local universities. All measures were repeated at post‐treatment, 6‐ and 12‐month follow‐up. Note: The term ‘parents’ is used to refer to the wide variety of people serving as a child's primary caregiver.ResultsPre‐treatment, all children met diagnostic criteria for full (N = 17) or sub‐clinical PTSD. By post‐treatment, 10.5% met criteria for PTSD, with 0% meeting criteria at the 12‐month follow‐up. The incidence of anxiety and depressive disorders also reduced significantly. There were no differences in outcomes for children seen by trainees compared to experienced clinicians.ConclusionsA school‐based screen‐and‐treat approach offers potential as a means of identifying and treating children following natural disaster exposure. However, engagement of families at the outset, and when offering intervention was challenging. Postgraduate trainees represent an effective potential workforce in a post‐disaster environment.
Neurocognitive training enhances the outcomes of children with attention deficit hyperactivity disorder: A preliminary study
Authors: Buker Nurullah , Karagoz Ezgi , Sengul Yesim Salik , Guney Sevay Alsen , Ozbek Aylin 
Published: May 2024

AbstractBackgroundAttention deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder characterized by diverse clinical manifestations including inattention, hyperactivity and impulsivity.ObjectiveThe present study aims to investigate the effects of neurocognitive training (NT), a personalized and specialized exercise programme on symptoms, attention and dynamic balance in treatment‐naïve children diagnosed with ADHD.MethodsFourteen treatment‐naïve children aged 7–12 years diagnosed with ADHD were enrolled in the intervention group. The NT intervention was administered weekly for 10 consecutive weeks, supplemented by a structured home exercise programme for 6 days a week over the same 10‐week period. ADHD‐related symptoms, attention and dynamic balance were assessed in pre‐treatment, post‐treatment, 6 months, and 12 months. Fifteen typically developing (TD) children, matched for age, underwent evaluation only once to establish baseline normative values.ResultsFollowing the NT (post‐treatment), significant improvements were observed in hyperactivity‐impulsivity scores, oppositional‐defiant behaviours and dynamic balance when compared to the TD children (p < 0.05). In the ADHD group, a significant difference was found in the long term (12‐month follow‐up) in hyperactivity–impulsivity, oppositional‐defiant behaviours and dynamic balance (p < 0.05).ConclusionThe findings suggest that the NT yields favourable effects on hyperactivity–impulsivity, oppositional defiant behaviours and dynamic balance in children diagnosed with ADHD, with these improvements appearing to be sustained over the long term.Clinical trial registration number: NCT04707040.
Metastatic triple‐negative breast carcinoma mimicking melanoma: A potential diagnostic pitfall
Authors: Fliorent Rebecca , Benedetto Conrad , Theroux Zachary 
Published: May 2024

AbstractMelanoma, with its diverse histopathologic characteristics, can mimic both benign nevi and neoplasms of various cell lineages. Immunohistochemistry (IHC) can play a vital role in melanoma diagnosis, particularly when the cell lineage is unclear on hematoxylin and eosin sections. Commonly utilized IHC stains for melanoma diagnosis include SOX10, Melan‐A, and S100. A relatively novel stain, PReferentially expressed Antigen in MElanoma (PRAME), is also proving useful in accurate melanoma diagnosis. However, none of these stains are completely specific to melanocytes or melanoma, and misinterpretation can lead to incorrect diagnoses. This report presents a unique case of triple‐negative breast carcinoma (TNBC) metastatic to the skin exhibiting histopathologic characteristics similar to melanoma, including positivity for SOX10 and PRAME. Our aim is to highlight TNBC metastatic to the skin as a potential diagnostic pitfall.
Procedural and clinical outcomes of patients undergoing a TAVI in TAVI procedure: Rationale and design of the multicentre, prospective, observational ReTAVI registry
Authors: Parma Radoslaw , Joner Michael , Saia Francesco , Cuisset Thomas , Delgado Victoria , Rodes‐Cabau Josep , Modine Thomas , Van Belle Eric , Fovino Luca Nai , Landes Uri , Alvarez‐Covarrubias Hector Alfonso , Abdel‐Wahab Mohamed , Zamorano Jose Luis , Eden Matthias , Cademartiri Filippo , Skipirzepa Joanna Nawara , Kurucova Jana , Greinert Daniel , Bramlage Peter , Tarantini Giuseppe 
Published: May 2024

AbstractBackgroundTranscatheter aortic valve implantation (TAVI) is increasingly being used in younger patients and those with lower peri‐procedural risk, meaning more patients will live long enough to experience structural valve deterioration (SVD) of the bioprosthesis, indicating repeated TAVI. Experience of repeated TAVI—transcatheter heart valve (THV) implantation into an index THV is limited. This registry aims to assess the peri‐procedural and short‐term safety, efficacy and durability of repeated TAVI.MethodsThe ReTAVI Prospective observational registry is an investigator‐initiated, multicentre, international, prospective registry of patients undergoing repeated TAVI using balloon‐expandable SAPIEN prosthesis to evaluate procedural and short‐term safety, efficacy and durability as well as anatomical and procedural factors associated with optimal results. The registry will enrol at least 150 patients across 60 high‐volume centres. Patients must be ≥18 years old, have had procedural success with their first TAVI, have index THV device failure, intend to undergo repeated TAVI and be considered suitable candidates by their local Heart Team. All patients will undergo a 30‐day and 12‐month follow‐up. The estimated study completion is 2025.ConclusionsThe registry will collect pre‐, peri‐, postoperative and 12‐months data on patients undergoing repeated TAVI procedures with THVs for failure of the index THV and determine VARC‐3‐defined efficacy and safety at 30 days and functional outcome at 12 months. The registry will expand existing data sets and identify patient characteristics/indicators related to complications and clinical benefits for patients with symptomatic severe calcific degenerative aortic stenosis.
Distinct responses to warming within picoplankton communities across an environmental gradient
Authors: Stevens Bethany L. F. , Peacock Emily E. , Crockford E. Taylor , Shalapyonok Alexi , Neubert Michael G. , Sosik Heidi M. 
Published: May 2024

AbstractPicophytoplankton are a ubiquitous component of marine plankton communities and are expected to be favored by global increases in seawater temperature and stratification associated with climate change. Eukaryotic and prokaryotic picophytoplankton have distinct ecology, and global models predict that the two groups will respond differently to future climate scenarios. At a nearshore observatory on the Northeast US Shelf, however, decades of year‐round monitoring have shown these two groups to be highly synchronized in their responses to environmental variability. To reconcile the differences between regional and global predictions for picophytoplankton dynamics, we here investigate the picophytoplankton community across the continental shelf gradient from the nearshore observatory to the continental slope. We analyze flow cytometry data from 22 research cruises, comparing the response of picoeukaryote and Synechococcus communities to environmental variability across time and space. We find that the mechanisms controlling picophytoplankton abundance differ across taxa, season, and distance from shore. Like the prokaryote, Synechococcus, picoeukaryote division rates are limited nearshore by low temperatures in winter and spring, and higher temperatures offshore lead to an earlier spring bloom. Unlike Synechococcus, picoeukaryote concentration in summer decreases dramatically in offshore surface waters and exhibits deeper subsurface maxima. The offshore picoeukaryote community appears to be nutrient limited in the summer and subject to much greater loss rates than Synechococcus. This work both produces and demonstrates the necessity of taxon‐ and site‐specific knowledge for accurately predicting the responses of picophytoplankton to ongoing environmental change.
Kierkegaard and Natural Law
Authors: Spinks Casey 
Published: May 2024

AbstractAbstract: This essay addresses the relationship between Kierkegaard and natural law afresh. First, I exposit Thomas's natural law doctrine in the Summa, particularly its theological emphasis on the God‐human relationship, which often goes underappreciated. Then, I argue that natural law doctrine downstream from Thomas suffers from an acute vulnerability: its natural aspect is emphasised so much that the divine‐human relationship at the heart of natural law falls away. Next, I argue Problema II of Fear and Trembling deals with this same issue and theologically criticises ethics’ secularising tendency. I then argue that Fear and Trembling and other writings of Kierkegaard's corpus claim a universal law similar to Thomas's doctrine: each individual must relate absolutely to God. Thereby, Kierkegaard transforms natural law from a general norm prone to secularisation into a gift and theological task for everyone, grounding the possibility of ethics in the divine‐human relationship. For regular dogmatic purposes, I suggest this shifts natural law to the doctrines of justification and sanctification.
Short (≤6 mm) compared with ≥10‐mm dental implants in different clinical scenarios: A systematic review of randomized clinical trials with meta‐analysis, trial sequential analysis and quality of evidence grading
Authors: Ravidà Andrea , Serroni Matteo , Borgnakke Wenche S. , Romandini Mario , Wang I‐Ching (Izzie) , Arena Claudia , Annunziata Marco , Cecoro Gennaro , Saleh Muhammad H. A. 
Published: May 2024

AbstractAimTo systematically identify, synthesize and critically summarize the available scientific evidence from randomized controlled trials (RCTs) regarding whether short (≤6 mm) perform as well as long (≥10 mm) implants regarding implant survival, marginal bone loss, and biologic and prosthetic complications in different clinical scenarios.Materials and MethodsCochrane Collaboration's risk of bias tool and the GRADE approach were applied. Results were synthesized using random‐effects meta‐analyses assessed by trial sequential analyses.ResultsForty reports on 19 RCTs comprising 2214 (1097 short; 1117 long) implants were included. Moderate/high certainty/quality evidence demonstrated similar 5‐year survival rates for ≤6‐mm and ≥10‐mm implants in non‐augmented bone and full‐mouth rehabilitation in either jaw, and for 6‐mm implants in the maxilla instead of sinus lift. Nevertheless, the evidence for 5‐year survival rates remains inconclusive or insufficient for the remaining combinations of implant lengths and clinical scenarios. They include 4‐mm and 5‐mm implants as alternatives to sinus lift as well as placing all implant lengths ≤6 mm instead of vertical ridge augmentation with long implants. Marginal bone level and short‐ and long‐term biologic or prosthetic complications were similar.ConclusionsBased on moderate/high certainty/quality evidence from 5‐year RCTs, implants ≤6 mm may be viable alternatives to ≥10‐mm implants in either jaw in native bone and full‐arch rehabilitation, and 6‐mm implants may be used as an alternative to sinus lift. Trial registration: PROSPERO ID: CRD42021254365.
Influence of stress resilience in adolescence on long‐term risk of psoriasis and psoriatic arthritis among men: A prospective register‐based cohort study in Sweden
Authors: Laskowski M. , Schiöler L. , Åberg M. , Abuabara K. , Wennberg A.‐M. , Gustafsson H. , Torén K. 
Published: May 2024

AbstractBackgroundAlthough stress is considered to be a negative factor for psoriasis, no convincing scientific evidence of this association exists, largely because of difficulties in measuring stress. Stress resilience is the ability to cope with and adapt to stressful events. Stress resilience can be measured in a standardized way and used as a marker for chronic stress.ObjectivesThe objective of this study is to investigate whether low stress resilience in adolescence increases the risk for onset of psoriasis and psoriatic arthritis later in life.MethodsA cohort of Swedish men (mean age 18.3 years), enrolled in compulsory military service between 1968 and 2005, was created using data from the Swedish Military Service Conscription Register (n = 1,669,422). Stress resilience at conscription was estimated using standardized semi‐structured interviews, and was divided into three categories: low, medium and high. The men were followed from conscription until new‐onset psoriasis or psoriatic arthritis, death or emigration or at the latest until 31 December 2019. Cox regression models adjusted for confounders at conscription were used to obtain hazard ratios (HRs) with 95% confidence intervals (CIs) for incident psoriasis and psoriatic arthritis.ResultsMen in the lowest stress resilience category had an increased risk of psoriasis and psoriatic arthritis (HR 1.31 (95% CI 1.26–1.36) and 1.23 (95% CI 1.15–1.32), respectively), compared with those in the highest stress resilience category. When including only hospitalized patients the HRs for psoriasis and psoriatic arthritis in the lowest stress resilience group were 1.79 (1.63–1.98) and 1.53 (1.32–1.77), respectively.ConclusionsThis large, prospective register study suggests that low stress resilience in adolescence is associated with an increased risk of incident psoriasis among men. The results indicate that patients with psoriasis have an inherent psychological vulnerability, and highlight the importance of addressing psychological well‐being in the management of psoriasis.
Evaluating ChatGPT's effectiveness and tendencies in Japanese internal medicine
Authors: Kaneda Yudai , Tayuinosho Akari , Tomoyose Rika , Takita Morihito , Hamaki Tamae , Tanimoto Tetsuya , Ozaki Akihiko 
Published: May 2024

AbstractIntroductionChatGPT, a large‐scale language model, is a notable example of AI's potential in health care. However, its effectiveness in clinical settings, especially when compared to human physicians, is not fully understood. This study evaluates ChatGPT's capabilities and limitations in answering questions for Japanese internal medicine specialists, aiming to clarify its accuracy and tendencies in both correct and incorrect responses.MethodsWe utilized ChatGPT's answers on four sets of self‐training questions for internal medicine specialists in Japan from 2020 to 2023. We ran three trials for each set to evaluate its overall accuracy and performance on nonimage questions. Subsequently, we categorized the questions into two groups: those ChatGPT consistently answered correctly (Confirmed Correct Answer, CCA) and those it consistently answered incorrectly (Confirmed Incorrect Answer, CIA). For these groups, we calculated the average accuracy rates and 95% confidence intervals based on the actual performance of internal medicine physicians on each question and analyzed the statistical significance between the two groups. This process was then similarly applied to the subset of nonimage CCA and CIA questions.ResultsChatGPT's overall accuracy rate was 59.05%, increasing to 65.76% for nonimage questions. 24.87% of the questions had answers that varied between correct and incorrect in the three trials. Despite surpassing the passing threshold for nonimage questions, ChatGPT's accuracy was lower than that of human specialists. There was a significant variance in accuracy between CCA and CIA groups, with ChatGPT mirroring human physician patterns in responding to different question types.ConclusionThis study underscores ChatGPT's potential utility and limitations in internal medicine. While effective in some aspects, its dependence on question type and context suggests that it should supplement, not replace, professional medical judgment. Further research is needed to integrate Artificial Intelligence tools like ChatGPT more effectively into specialized medical practices.
Development of a chemiluminescence detection technique for malachite green
Authors: Sun Yang , Zeng Shuiyu , Guo Chaolin , Zhou Pei , Xu Yinbiao , Jin Kuiqi , Han Feifei , Liu Yupeng , Li Hua , Bai Zhonghu 
Published: May 2024

AbstractMalachite green (MG), a triphenylmethane dye is often used as a fungicide and preservative in fisheries due to its effectiveness against water molds in fish and fish eggs. However, excessive inhalation can be hazardous to human health. To quantify the MG concentration, we created and evaluated a 96‐well plate‐based chemiluminescence immunoassay (CLIA). This method used provided readings in <30 min, with an optimal incubation time of 15 min and a limit of detection of 0.20 ng·ml−1. The strong correlation (R2 >0.99) between the measured values of real fish samples examined using the method and the high‐performance liquid chromatography results confirmed the accurate quantitative detection of MG. In this study, CLIA was also used in conjunction with point‐of‐care testing (POCT) to greatly improve the efficiency of the experiments. Thus, a quantitative detection method based on MG plate chemiluminescence was established herein, with performance indexes that meet the requirements of on‐site detection. This approach is also applicable to the detection of small molecule compounds such as chloramphenicol and sulfadiazine pyrimethamine, providing a new direction in the field of food safety detection.