bluuebunny/crossref_metadata_2025_split huggingface dataset:
0982 Quadratic Association Between Ecologically Assessed Sleep Duration and Next-day Suicidal Ideation in Youth
Authors: Kudinova Anastacia , Nesi Jacqueline , Ryan Sarah , Diab Ella , Carskadon Mary 
Published: April 2024

Abstract

Introduction
Sleeping too little or too much has been linked to adverse mental health outcomes in youth. Most studies that described the link between sleep duration and suicide risk in youth, however, relied on a single assessment of sleep and suicidal ideation, with considerable temporal gaps in between. Characterizing the proximal link between sleep duration and suicide risk in children and adolescents is essential for developing informative, early mobile interventions. We examined the association between ecologically assessed suicidal ideation (SI) and sleep duration in youth recruited after a partial hospitalization program. We also examined contextual factors in relation to sleep duration that are particularly salient for youth, including nighttime social media use and social media use-related self-referential cognitions.

Methods
We used ecological momentary assessment (EMA) 3 times/day over two weeks in discharged partial hospital patients to assess their levels of SI at home (n=79; 62% assigned F at birth; ages 12-15; mean 13.52; sd 1.14 yr). We also asked youth to report their bedtimes and waketimes every morning for two weeks. Social media use was assessed once via a questionnaire.

Results
Using generalized linear mixed models, we showed a significant quadratic effect of sleep duration on next-day SI (B=–0.04, SE =0.01, p&lt; 0.001). The turning point of the quadratic function was the sleep duration of 10 hours. Specifically, longer sleep was linked to lower next-day SI, with this association reversing at 10 hours of sleep. Nighttime social media use (B=–0.18, SE =0.05, p&lt; 0.001) and engaging in social media use-related self-criticism (B=–0.10, SE =0.05, p&lt; 0.05) were both linked to shorter sleep duration, whereas daytime social media use was not associated with sleep duration (p&gt;0.05).

Conclusion
These preliminary findings point to a curvilinear association between how long children and adolescents sleep and how much they think about suicide the following day and highlight the significance of social media use at bedtime. The findings emphasize the potential clinical relevance of daily assessment of sleep duration in developing adaptive, just-in-time interventions to decrease suicide risk in youth.

Support (if any)
NIMH Career Development (K23MH122587) Award; Bradley Hospital COBRE Center (P20GM139743).
0983 Reciprocal Relations Between Sleep and Alcohol Use
Authors: Tussey Emma , Wong Maria 
Published: April 2024

Abstract

Introduction
Prior studies have established a longitudinal association between sleep disturbance and the development of alcohol use disorder. Experimental research also shows that alcohol intake negatively impacts sleep. The present study evaluated the reciprocal relationship between sleep and alcohol use with intensive longitudinal methods. We hypothesized that sleep disturbance would predict greater next-day alcohol intake and that greater alcohol intake would predict greater same-night sleep disturbance.

Methods
50 college students (70% female, mean age 24) participated in a two-week study assessing their daily sleep and alcohol use patterns. Participants wore the Phillips Actiwatch Spectrum and completed daily diaries capturing self-reported sleep and alcohol intake. Multi-level zero-inflated binomial models assessed whether prior sleep predicted next-day alcohol use, including the likelihood of abstaining from alcohol the next day and alcohol intake amongst individuals who do drink. Linear multi-level models assessed whether alcohol use predicted daily sleep. All models assessed both within-subject (daily) and between-subject (average) effects because daily variations in sleep may influence alcohol use separately from average patterns and vice versa—models controlled for race, age, and gender.

Results
Participants with greater average sleep onset latency (SOL) were less likely to drink the next day (OR: 1.02 p &lt; .05). Among those who drank, greater average wake after sleep onset (WASO) and SOL and shorter daily total sleep time (TST) predicted greater next-day alcohol intake (WASO IR: 1.01; SOL IR: 1.01; TST IR: 0.998; p &lt; .05). Higher average alcohol intake predicted increased daily WASO (B = 10.3, SE = 4.4, p &lt; .05), TST (B = 15.0, SE = 5.1, p &lt; .05), and decreased daily sleep quality (B = -0.13, SE = .06, p &lt; .05). Daily alcohol intake did not predict sleep variables.

Conclusion
These results suggest there is a dynamic reciprocal relationship between sleep and alcohol use. Individuals with worse average sleep continuity were less likely to drink alcohol. However, among those who chose to drink, lower average sleep continuity and shorter daily sleep duration predicted greater alcohol intake. These results suggest that sleep disturbance is a risk factor for developing excessive alcohol use.

Support (if any)
Idaho State University, Graduate School; PSI CHI; INBRE.
0987 Physical Activity as a Tool to Improve Sleep Quality for Secure Psychiatric Inpatients: A Pilot Feasibility Study
Authors: Gardiner Poppy , Kinnafick Florence , Breen Kieran , Hartescu Iuliana 
Published: April 2024

Abstract

Introduction
People with severe mental illness (SMI) may receive inpatient care in a secure facility. Due to highly prevalent sleep disorders such as insomnia, and common daytime behaviours such as napping and inactivity, many of these patients experience disrupted sleep/wake cycles. Sleep/wake cycles can be retrained by increasing daytime physical activity (PA), however, patients with SMI are highly sedentary. For sedentary groups, engaging in multiple short bouts of PA across the day may feel more attainable than completing one longer bout. Therefore, we conducted a pilot study to investigate the feasibility of an intermittent PA intervention to improve sleep quality for psychiatric inpatients residing in secure healthcare.

Methods
N=22 inpatients (40.0±16.9y, 16 males) from a secure psychiatric hospital (England) participated in a ten-week, theory-informed, PA intervention. Participants were instructed to engage in three ten-minute bouts of PA/day, five days/week, completed at a self-selected intensity. At baseline, mid-point (week 5), and post-intervention, inpatients completed questionnaires, including the Insomnia Severity Index (ISI) (primary outcome). The wrist-worn Motionwatch8 actigraph was used to record sleep and PA data (including total sleep time (TST), sleep efficiency (SE), and moderate-to-vigorous PA (MVPA)).

Results
Pre-to-post intervention, mean ISI scores decreased from 12.14 (SD=4.98) to 11.38 (SD=6.18) (t(20)=0.65,p=0.53). Actigraphy data was used to derive five time-points across the sleep/wake cycle. Mean wake time advanced by 34min (SE=15.92min), time to get out of bed advanced 34min (SE=14.31min), and mid-point of sleep advanced 38min (SE=15.93min). These advances were significant (p&lt; 0.05). Mean time to bed and time to sleep also advanced (both p&gt;0.05). Mean MVPA increased by 17min/day (T=1.17, p&gt;0.05). Other sleep indices (including TST, SE) did not change significantly. PA adherence scores were highly variable person-to-person. All participants remained in the trial from intervention week 1 to post-intervention.

Conclusion
Intermittent PA can decrease insomnia symptoms and significantly advance sleep phase in secure psychiatric inpatients. Though habitually sedentary, MVPA can be increased in this population. The impact of age, gender, or diagnosis could not be specified due to small sample size. Future research with larger, more diverse samples would be beneficial to support these promising early results.

Support (if any)
Loughborough University (UK), St Andrew’s Healthcare (UK)
0991 Fear of Missing out and Sleep Health: A Systematic Review and Meta-analysis
Authors: Brombach Ruth , Dietch Jessica 
Published: April 2024

Abstract

Introduction
Fear of missing out (FoMO) refers to anxiety and apprehension an individual feels when they believe they are missing out on rewarding experience, social interaction, or information. FoMO has been associated with negative psychological and behavioral symptoms and might also impact sleep health. This meta-analysis therefore aimed to examine the existing literature on the relationship between FoMO and dimensions of sleep health.

Methods
A systematic literature search across PubMed, PsycINFO, and Web of Science was conducted in August 2023. Primary inclusion criteria were original research studies that test the relationship between FoMO and a dimension of sleep health. Of the primary 268 studies identified, 16 were included in the final analysis.

Results
Meta-analytic results of the random-effects model applied to a total of 3 independent samples showed a positive correlation between FoMO and Bedtime Procrastination (Fisher’s Z = 0.250; 95% CI 0.137, 0.362; Z = 4.348; p &lt;.001). Additionally, meta-analytic results of the random-effects model applied to a total of 5 independent samples showed a positive correlation between FoMO and Sleep Hygiene (Fisher’s Z = 0.268; 95% CI 0.186, 0.350; Z = 6.419; p &lt;.001) and Sleep Quality (Fisher’s Z = 0.305; 95% CI 0.038, 0.572; Z = 2.240; p = 0.025). Additionally, two or less independent samples showed positive significant relations between FoMO and insomnia, later lights out time, problematic sleep, sleep-deprivation, SOL and TST.

Conclusion
FoMO seems to be related to different dimensions of sleep health. It seems like the constant urge to stay connected or engaged can lead to sacrificing essential sleep hours, resulting in decreased sleep quality and procrastinated bedtime. This can have effects on various aspects of physical and mental health. Therefore, addressing FoMO may be relevant in improving sleep health. While our findings are significant, it's crucial to acknowledge the limitations of drawing conclusions from some of our results, which were based on findings from just one study. This highlights the need for further comprehensive research to establish a better understanding of the relationship between FoMO and sleep health. Future research should additionally focus on conducting longitudinal studies to understand the direction of the relationships better

Support (if any)
0992 Hippocampal Response to Sleep Sound Moderates Impact of Depressed Mood on Daytime Sleepiness in Shift Workers
Authors: Shin Jiyoon , Lee Kyung Hwa , Seo Won Woo , Jeon Jeong Eun , Lee Ha Young , Yoo Jin Hyuk , Kim Sun-Young , Kim Seog Ju , Lee Yu Jin 
Published: April 2024

Abstract

Introduction
Shift workers (SW) commonly experience mood symptoms, which is known to be linked to sleep disturbances and disrupted 24-hour rest-activity rhythm (RAR). Altered brain response to sleep-related sound (SS) were reported to be associated with dysfunctional appraisals of sleep and sleep disturbances. In current study, we aimed to investigate differences in brain activity in response to SS between SW and control participants (CON). Furthermore, we explored the moderation effects of brain response to SS on the relationships between daytime sleepiness, mood symptoms and 24-hour RAR in SW.

Methods
SW (n=57, female 75.4%) and CON (n=56, female 71.4%) completed questionnaires (Epworth Sleepiness Scale (ESS), Beck Depression Inventory (BDI), and Beck Anxiety Inventory). Participants also underwent one-night polysomnography and actigraphy with sleep diary for one week. We calculated 24-hour RAR with cosinor analysis on actigraphy parameters. Functional magnetic resonance imaging was performed while listening to SS and control sounds (CS). We compared brain activation in response to SS (vs. CS) between SW and CON. In addition, we conducted a moderation analysis with ESS as a dependent variable and BDI, BAI, and 24-hour RAR as independent variables. Brain activities with significant differences between SW and CON were used as moderators.

Results
SW showed higher ESS score (t = 2.28, p = 0.025) and lower interdaily stability, relative amplitude, and higher least active 5-hour period (all-ps &lt; 0.001). SW also showed higher activity to SS in right hippocampus (t = 3.61, p &lt; 0.001) and MFG (t = 3.57, p &lt; 0.001) compared to CON. In SW, right hippocampus activity (HA) in response to SS moderated the relationship between BDI and ESS (F = 7.61, adjusted R-squared = 0.265, p &lt; 0.001, high HA; r = 0.433, low HA; r = 0.051).

Conclusion
Current results suggested differential brain activity to sleep-related stimuli in SW. Moreover, the findings indicate that decreased right HA in SW can be associated with increased impact of depression on daytime sleepiness. Therefore, modulating HA and managing depressive symptoms can be helpful in reduction in excessive daytime sleepiness among SW.

Support (if any)
National Research Foundation (No. 2016M3C7A1904338 and No. 2022R1A2C1008209).
0997 Preliminary Analyses of Sleep and Psychotic-like Experiences in a Clinical High-Risk Sample
Authors: Kelly Brennan , Akhras Sarah , Orellana Stephanie , Lott Morgan , Koesterer Sophia , Banik Nandita , McCleery Amanda , Baran Bengi 
Published: April 2024

Abstract

Introduction
While sleep disturbances are common in individuals with psychotic disorders, and are shown to exacerbate symptoms and cognitive deficits, less is known about sleep in youth at heightened clinical high risk (CHR) for psychosis. The goals of the present study were to identify CHR individuals using well-established clinical criteria, quantify sleep using wearable technology, and investigate the relations between objective measures of sleep with endorsed psychotic-like experiences (PLEs) and associated distress.

Methods
Participants were recruited from the Psychosis-risk Intervention, Education, and Research (PIER) Program. While data collection is ongoing for this longitudinal study, current analyses were based on 9 participants (67% female, 11% male, 22% non-binary, ages 13-33). Self-reports on the Prodromal Questionnaire-Brief were used to quantify PLEs and associated distress. Sleep was measured at home with an EEG headband (Sleep Profiler) and scored according to standard AASM criteria.

Results
Preliminary analyses reveal great variability in sleep efficiency (56-97%) and Wake After Sleep Onset (5-101 min). Contrary to our predictions, we observed no significant relations between sleep duration, efficiency, or architecture and PLEs (all p’s &gt;.5).

Conclusion
In this group of help-seeking individuals we did not observe significant relations between sleep indices and self-reported PLEs. The current study has several limitations such as a small sample size and clinical heterogeneity, and relied on self-reported measures of PLEs completed by participants online. With data collection still under way, future plans include obtaining objective clinical phenotypes (e.g., utilizing the Structured Interview of Psychosis-risk Syndromes to categorize clinical high risk status) and investigating how sleep and PLEs change over time.

Support (if any)
Effectiveness of Sodium–Glucose Cotransporter 2 Inhibitors in Patients With Acute Myocardial Infarction With or Without Type 2 Diabetes: A Systematic Review and Meta-analysis
Authors: Zhang Xuefang , Sun Gang , Li Zhiquan , Gao Weidong , Tan Wenfeng , Liu Jinxue , Zhang Bin , Wu Juan , Chen Rong , Li Xiu Juan , Zhang Gaoxing 
Published: April 2024

Abstract:
Recent studies have revealed the benefits of sodium–glucose cotransporter 2 inhibitors (SGLT2i) in heart failure patients. However, their effects on acute myocardial infarction (AMI) remain uncertain. Therefore, we conducted this meta-analysis to assess the effectiveness of SGLT2i in patients with AMI with or without diabetes. We conducted a comprehensive search of PubMed, Embase, and Cochrane Library encompassing data from inception until November 30, 2023. Relevant studies comparing SGLT2i with placebo or non-SGLT2i in patients with AMI were included. The mean difference and/or odds ratio (OR) with 95% confidence intervals were pooled using a fixed-effects model when the heterogeneity statistic (I2) was less than 50%; otherwise, a random-effects model was employed. Four randomized controlled trials and 4 observational studies involving 9397 patients with AMI were included in this meta-analysis. Patients treated with SGLT2i exhibited a significantly lower rate of hospitalization for heart failure (OR = 0.50, 95% CI: 0.32–0.80) and all-cause death (OR = 0.65, 95% CI: 0.44–0.95) compared with those treated with placebo or non-SGLT2i. Furthermore, the use of SGLT2i was associated with a significant increase in left ventricular ejection fraction (mean difference = 1.90, 95% CI: 1.62–2.17) and a greater reduction of N-terminal prohormone of brain natriuretic peptide (OR = 0.88, 95% CI 0.82–0.94). Subgroup analysis revealed that in patients with diabetes, SGLT2i exhibited similar effects. The present meta-analysis provided evidence indicating the effectiveness of SGLT2i in patients with AMI; SGLT2i may serve as an additional therapeutic option for patients with AMI, regardless of the presence or absence of diabetes.
Palaeoproteomic identification of a whale bone tool from Bronze Age Heiloo, the Netherlands
Authors: Dekker Joannes A. A. , Mylopotamitaki Dorothea , Verbaas Annemieke , Sinet-Mathiot Virginie , Presslee Samantha , McCarthy Morgan L. , Olsen Morten Tange , Olsen Jesper V. , Hurk Youri van den , Brattinga Joris , Welker Frido 
Published: April 2024

AbstractIdentification of the taxonomic origin of bone tools is an important, but often complicated, component of studying past societies. The species used for bone tool production provide insight into what species were exploited, potentially how, and for what purpose. Additionally, the choice of species may have important implications for the place of the tool within the larger toolkit. However, the taxonomic identification of bone tools is often unsuccessful based on morphology. Here we apply three palaeoproteomic techniques, ZooMS, SPIN-like data analysis and a targeted database search to narrow down the taxonomic identification of an unusually large Bronze Age bone tool from Heiloo, the Netherlands, to the North Atlantic right whale (Eubalaena glacialis). Additionally, the tool was investigated for use-wear, which showed that it was likely used for the processing of plant fibres. The assignment of the tool as whale bone adds support to the exploitation of whales by coastal Bronze Age populations, not just for meat, as previously suggested, but also for bone as a resource for tool production. We know of no other parallel of a bone tool such as this in terms of size, use, hafting, and taxonomic identity.
Evolutionary paleoecology of European rhinocerotids across the Oligocene-Miocene transition
Authors: Hullot Manon , Martin Céline , Blondel Cécile , Becker Damien , Rössner Gertrud E. 
Published: April 2024

AbstractThe Oligocene-Miocene transition witnessed great environmental and faunal changes, spanning from late Oligocene to early Miocene (MP28-MN3). Its drivers and consequences on mammals are however poorly understood. Rhinocerotoids are among the most affected taxa, reflected by great taxonomical and morphological changes. However, potential associated changes in ecology have not been explored. Here, we investigated the paleoecology of 10 rhinocerotid species coming from 15 localities across Western Europe and ranging from MP28 to MN3. We explored evolutionary trends for diet, physiology, and habitat via dental wear, hypoplasia, body mass, and stable isotopy. All rhinocerotids studied were C3 feeders, whether browsing or mixed-feeding, but clear dietary differences were observed at some localities and between Oligocene and Miocene rhinocerotids. The prevalence of hypoplasia was low (< 10 %) to moderate (< 20 %), but there were great differences by loci, species, and localities. Body mass co-variated with hypoplasia prevalence, suggesting that larger species might be more susceptible to stresses and environmental changes. We reconstructed similar warm conditions at all localities except Gaimersheim, but found greater variations in precipitation. Indeed, a clear shift in δ13C values was noticed at the end of the Oligocene, consistent with climatic and vegetation changes reported at that time.
Functional and antigenic landscape of the Nipah virus receptor binding protein
Authors: Larsen Brendan B. , McMahon Teagan , Brown Jack T. , Wang Zhaoqian , Radford Caelan E. , Crowe James E. , Veesler David , Bloom Jesse D. 
Published: April 2024

AbstractNipah virus recurrently spills over to humans, causing fatal infections. The viral receptor-binding protein (RBP or G) attaches to host receptors and is a major target of neutralizing antibodies. Here we use deep mutational scanning to measure how all amino-acid mutations to the RBP affect cell entry, receptor binding, and escape from neutralizing antibodies. We identify functionally constrained regions of the RBP, including sites involved in oligomerization, along with mutations that differentially modulate RBP binding to its two ephrin receptors. We map escape mutations for six anti-RBP antibodies, and find that few antigenic mutations are present in natural Nipah strains. Our findings offer insights into the potential for functional and antigenic evolution of the RBP that can inform the development of antibody therapies and vaccines.
Cardiovascular Health Effects and Synthetic Cooling Agents in E-cigarettes Labeled as ‘clear’ Marketed in Massachusetts After the Tobacco Product Flavoring Ban
Authors: Minetti Erika T. , Erythropel Hanno C. , Keith Rachel , Davis Danielle R. , Zimmerman Julie B. , Krishnan-Sarin Suchitra , Hamburg Naomi M. 
Published: April 2024

AbstractIntroductionMassachusetts (MA) enacted statewide regulation on all flavored tobacco products in June 2020. Thereafter, electronic cigarettes (e-cigarettes) labeled ‘clear’ emerged on the market. We aimed to combine cardiovascular health effects with chemical analysis of ‘clear’ e-cigarettes.MethodsWe measured acute changes in blood pressure and heart rate following a 10-minute structured use of participants’ own e-cigarette, comparing ‘clear’ e-cigarette users with other flavored e-cigarette users and non-users. Chemical characterization and quantification of relevant flavorings and cooling agents (WS-3, WS-23) of 19 ‘clear’-labeled disposable e-cigarette liquids was carried out by GC/MS.ResultsAfter the ban, participants that used ‘clear’ labeled e-cigarettes increased from 0% to 21%. Increase in diastolic blood pressure and heart rate was significantly greater in ‘clear’ e-cigarettes users (n=22) compared to both non-’clear’ flavored e-cigarette users (n=114) and non-users (n=72). We saw similar results in heart rate when comparing Juul e-cigarette and ‘clear’ users; Juul was used as a reference as synthetic coolants WS-3 or WS-23 were not detected in these.All (19/19) ‘clear’ e-liquids were found to contain synthetic cooling agents WS-23 and/or WS-3, menthol (18/19), as well as other flavorings (12/19).DiscussionThe detected presence of menthol alongside other flavorings in tested ‘clear’ products is a direct violation of the MA flavored tobacco product regulation, warranting stricter monitoring for new products and constituents. ‘clear’ e-cigarette use led to greater hemodynamic effects compared to other flavored e-cigarettes and Juul, which raises questions about the effect of cooling agents on users.