bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of lakes in inflow of water and biogenic substances in the polish part of the southern Baltic Sea
Authors: Jańczak Jerzy , Niemirycz Elżbieta 
Published: October 2011

Abstract
Polish rivers, which make up 20% of the Baltic Sea’s catchment area, transport a load of nitrogen and phosphorus compounds into the sea. Theoretically, this load should be strongly correlated with the amount of water flowing in those rivers. However, this is not the case, especially in terms of the phosphorus compounds, since most of them come from point source pollution. The outflow load is also significantly influenced by nonpoint source pollution from farmland, which is very difficult to quantify. About 50% of nitrogen and 30% of phosphorus appear to come from nonpoint source pollution. It is important to realize that the load from nonpoint source pollution also includes the load of phosphorus and nitrogen transformed by lakes. Only recently, however, has this issue been mentioned in the specialist literature. In Polish studies on lake balance this remains a marginal issue. A limited number of observations indicate that lakes are capable of both limiting and increasing the load (mainly from the bottom sediments). This article presents some data on this issue which suggest that the roles of lakes in the transformation of the load of biogenic substances may be significant, but diverse.
Anti-Hdv Immunoglobulin M Testing in Hepatitis Delta Revisited: Correlations with Disease Activity and Response to Pegylated Interferon-α2A Treatment
Authors: Mederacke Ingmar , Yurdaydin Cihan , Dalekos George N , Bremer Birgit , Erhardt Andreas , Cakaloglu Yilmaz , Yalcin Kendal , Gurel Selim , Zeuzem Stefan , Zachou Kalliopi , Bozkaya Hakan , Dienes Hans Peter , Manns Michael P , Wedemeyer Heiner ,   Hep-Net/International Delta Hepatitis Study Group
Published: October 2011

Background The role of anti-HDV immunoglobulin M (IgM) testing in patients receiving pegylated interferon-α therapy for hepatitis delta is unknown. We performed anti-HDV IgM testing in a well defined cohort of HDV-infected patients who were treated with pegylated interferon-α2a plus adefovir, or either drug alone. Methods Sera from 33 HDV-RNA-positive patients from the international HIDIT-1 trial were available for anti-HDV IgM testing (ETI-DELTA-IGMK-2 assay, DiaSorin, Saluggia, Italy) before therapy, at treatment weeks 24 and 48, and at 24 weeks after the end of treatment. Results Anti-HDV IgM tested positive in 31 out of the 33 patients (94%) prior to treatment. HDV IgM levels correlated with histological inflammatory activity ( r=0.51, P<0.01) and were higher in patients with alanine aminotransferase and γ-glutamyl transpeptidase levels above the median ( P<0.05). Quantitative anti-HDV IgM values declined in patients responding to antiviral therapy, however anti-HDV IgM remained positive after treatment in the majority of virological responders. Conclusions We suggest that anti-HDV IgM testing might give additional useful information to determine disease activity in hepatitis delta and to predict treatment response to antiviral therapy with type I interferons. However, determination of anti-HDV IgM can not substitute HDV RNA testing, which remains the primary virological marker for response to therapy.
Pleconaril Revisited: Clinical Course of Chronic Enteroviral Meningoencephalitis after Treatment Correlates with In Vitro Susceptibility
Authors: Wildenbeest Joanne G , van den Broek Peterhans J , Benschop Kimberley SM , Koen Gerrit , Wierenga Peter C , Vossen Ann CTM , Kuijpers Taco W , Wolthers Katja C 
Published: October 2011

Background Human enteroviruses (HEVs) can cause severe infections, especially in patients with a deficient humoral immune response, such as X-linked agammaglobulinemia. In this patient group, chronic enteroviral meningitis (CEMA) is feared because of extensive morbidity and high fatality rate. Treatment options consist of intravenous immunoglobulin (IVIG), with various outcomes. Pleconaril is an antiviral agent with in vitro activity against HEVs that has been used in the treatment of HEV infections. Methods The efficacy of pleconaril and IVIG against HEV isolated from the patients was assessed in vitro in two patients with CEMA. Results Echovirus 11 was found in the cerebrospinal fluid (CSF) of case 1. Treatment with high-dose IVIG and pleconaril did not provide any clinical improvement and HEV PCR in CSF remained positive. Case 2 (echovirus 13 positive in CSF) was also treated with IVIG and pleconaril. The patient recovered completely and HEV PCR in CSF became negative. Recent IVIG batches contained low titres of neutralizing antibodies against the patient strains. Echovirus 11 (case 1) was resistant to pleconaril in vitro, whereas echovirus 13 (case 2) was susceptible, in accordance with virological response after treatment and subsequent clinical results. Conclusions This is the first report that evaluates efficacy of antiviral treatment in CEMA patients in relation to in vitro susceptibility of clinical virus isolates. Since pleconaril is no longer available for compassionate use we strongly propagate that new drugs should be developed against these potential life threatening HEV infections.
A European Perspective on Topical Ophthalmic Antibiotics: Current and Evolving Options
Authors: Bremond-Gignac D. , Chiambaretta F. , Milazzo S. 
Published: October 2011

Background Eye infections can be vision-threatening and must be treated effectively by appropriate and safe use of topical ophthalmic anti-infectives. This review will essentially consider the current and evolving treatment options for the various types of bacterial eye infections. Ocular surface bacterial infections affect subjects of all ages with a high frequency in newborns and children. Methods This article presents a review of the peer-reviewed published scientific literature in order to define the well-established uses of anti-infective eye drops in the field of ocular infections. A comprehensive search of the recent published literature including topical ophthalmic anti-infectives effective in bacterial ocular infections was performed. Clinical studies provide relevant data concerning the characteristics and clinical efficacy of antibacterial eye drops in ocular anterior segment infections or for perioperative prophylaxis. Publications were included to cover the current options of antibacterial eye drops available in Europe. Results Several recent publications identified effective topical ocular antibacterials requiring a reduced dose regimen and a short treatment course. Additional literature reviewed included data on novel perioperative prophylaxis, indications for topical fortified antibiotics and innovative research including the risk of resistance. Conclusions Safe and effective topical antibiotic eye drops for the treatment and prevention of ocular infections must be adapted to the type of bacteria suspected. Usual topical antimicrobials should be replaced by more recent and more effective treatments. The use of highly effective fluoroquinolones should be reserved for the most severe cases to avoid resistance. Short treatment courses, such as azithromycin, can be easily used in children, thereby improving quality of life.
Exploring the Relationship between Affect and Sensory Processing Patterns in Adults
Authors: Engel-Yeger Batya , Dunn Winnie 
Published: October 2011

Purpose: Growing evidence exists regarding the relationship between sensory processing and affective disorders. However, most of this evidence relates to children. This study aimed to explore the relationship between positive/negative affect and sensory processing patterns as expressed in daily situations among healthy adults. Procedure: Two hundred and thirteen healthy individuals aged 18–50 years completed the Adolescent/Adult Sensory Profile (AASP) and the Positive and Negative Affect Schedule (PANAS). Results: Negative affect correlated positively with Sensory Sensitivity, Sensation Avoiding and Low Registration. Positive affect correlated with Sensation Seeking. Conclusion: Sensory processing patterns might be related to the person's affect. In practical terms, this relationship among typical individuals suggests that people could benefit from knowledge about the impact of their sensory processing patterns on everyday life or, in some cases, from occupational therapy intervention. Nevertheless, further studies are needed to elucidate this relationship and its impacts on participation, quality of life and wellbeing.
Low-Concentration Infracyanine Green–Assisted Internal Limiting Membrane Peeling in Idiopathic Macular Pucker 25-Gauge Surgery
Authors: Veritti Daniele , Toneatto Giacomo , Lanzetta Paolo 
Published: October 2011

Purpose To investigate the efficacy of 25-gauge infracyanine green–assisted idiopathic macular pucker surgery and to identify prognostic factors. Methods In this retrospective interventional case series, 83 patients with idiopathic macular pucker who underwent 25-gauge surgery with infracyanine green–assisted internal limiting membrane (ILM) peeling were retrospectively reviewed. Best-corrected visual acuity (BCVA) measurement, complete ophthalmologic evaluation, and optical coherence tomography were performed at baseline and during follow-up. Preoperative and postoperative prognostic factors were correlated with final visual outcomes. Results Mean follow-up was 10.5 months (range 3-44). Best-corrected visual acuity improved from 0.56±0.27 logMAR (±SD) to 0.26 ±0.18 logMAR (p<0.001); central retinal thickness decreased from 441±115 μm to 355±72 μm (p<0.001). Greater postoperative visual gain was correlated with baseline BCVA (r=–0.65, p<0.0001), and BCVA gain after 1 week (r=0.64, p<0.0001) and 1 month (r=0.58, p<0.0001). Final BCVA was influenced by baseline BCVA (r=0.46, p<0.0001), BCVA change after 1 month (r=0.34, p=0.002), and presence of intraretinal fluid (r=0.28, p=0.01). No cases of endophthalmitis, retinal tears, or retinal detachments were reported. Conclusions Low-concentration infracyanine green–assisted ILM peeling during minimally invasive surgery is associated with significant visual acuity improvement. Preoperative BCVA and optical coherence tomography appearance may be helpful in predicting the final visual outcome.
Comparison between Soft Gelatin Capsule Containing Ibuprofen and Ibuprofen Regular Tablet in Pain Control Following Scaling and Root Planing
Authors: Jenabian Niloufar , Naderi Ezzatollah , Moghadamnia Ali-Akbar , Zahedpasha Samir 
Published: October 2011

Aim: Scaling and root planing (SRP) is a major component of periodontal therapy which is often accompanied by painful experiences for the patient. The objective of the present study is to evaluate the pain control of two available types of ibuprofen, soft gelatin capsules and tablets, following SRP in patients with chronic periodontitis.
Methodology: 75 patients with chronic periodontitis, undergoing routine periodontal SRP were selected. Following probing the amount of pain perceived was recorded as the baseline pain using visual analog scale (VAS). Further, they received either 800 mg ibuprofen tablet, 800 mg ibuprofen capsule or placebo and the pain level was measured thirty minutes thereafter. Participants underwent SRP procedure and the pain levels were recorded immediately and then at 30 and 60 minutes after SRP.
Results: The mean VAS pain scores assessed immediately, thirty minutes and an hour after SRP for both ibuprofen and ibuprofen capsule groups were lower than placebo. Significant difference in the pain parameter only immediately after SRP between three groups were observed (p=0.012).The mean VAS pain score difference after thirty minutes and an hour upon SRP with baseline was insignificant in all study groups (p≤0.0001). However, the mean VAS pain score measured an hour after SRP showed significant difference between both NSAID groups and placebo group (p=0.012)
Conclusions: Soft gelatin ibuprofen capsules are well suitable for pain management during SRP procedure in patients with chronic periodontitis due to reported rapid onset of action and less gastrointestinal intolerance.
How to cite this article: Jenabian N, Naderi E, Moghadamnia AA, Zahedpasha S. Comparison between Soft Gelatin Capsule Containing Ibuprofen and Ibuprofen Regular Tablet in Pain Control Following Scaling and Root Planing. Int Dent Res 2011;2:42-47.
Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.
Comparison of the Impact of Long-Term Applications of MTAD and EDTA Irrigation Agents on Dentin Structure: A Scanning Electron Microscope Study
Authors: Kaya Sadullah , Ganidağlı Ayaz Selengül , Uysal İbrahim , Akkuş Zeki 
Published: October 2011

Aim: The purpose of this study was to compare the effects of 20-min applications of MTAD and 15% ethylenediaminetetraacetic acid (EDTA) solutions during final irrigation on the demineralization of root canal dentin.
Methodology: Forty mandibular and maxillary single-rooted teeth were randomly divided into two groups. During initial irrigation following the use of each file, 2 mL of 2.5% sodium hypochloride (NaOCl) solution was applied to all teeth. During final irrigation, 5 mL of EDTA solution was applied to the teeth in Group 1 and 5 mL MTAD solution was applied to the teeth in Group 2. Both solutions were applied for 20 min. All teeth were then washed with 5 mL distilled water and dried with paper points. The teeth were buccolingually bisected along the long axes using hammers and chisels. Scanning electron microscopic (SEM) images were then obtained and scored.
Results: Mann–Whitney U tests revealed significant differences between the MTAD and EDTA groups (p < 0.001).
Conclusions: The EDTA solution produced more demineralized areas in the dentin tubules than the MTAD solution.
How to cite this article: Kaya S, Ayaz SG, Uysal İ, Akkuş Z. Comparison of the Impact of Long-Term Applications of MTAD and EDTA Irrigation Agents on Dentin Structure: A Scanning Electron Microscope Study. Int Dent Res 2011;2:60-64.
Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.
Nuclear Protein in Testis Midline Carcinomas: A Lethal and Underrecognized Entity
Authors: Davis Brian N. , Karabakhtsian Rouzan G. , Pettigrew Anjana L. , Arnold Susanne M. , French Chris A. , Musgrave Brill Yolanda 
Published: October 2011

A 54-year-old woman presented with a nasal mass. Biopsy demonstrated undifferentiated tumor cells with extensive apoptosis and necrosis. Chromosome analysis identified a 46,XX,t(15;19)(q13;p13.1) pattern. Nuclear protein in testis (NUT) immunohistochemistry and fluorescence in situ hybridization confirmed NUT rearrangement. A Ewing sarcoma–based chemotherapy regimen and concurrent irradiation obtained a dramatic response; however, the patient died of her disease less than 7 months after initial diagnosis. NUT midline carcinomas are rare, aggressive tumors defined by rearrangement of the NUT gene on 15q14. A solitary translocation involving 15q14 is usually the sole chromosomal abnormality in these carcinomas. Immunohistochemical expression of NUT in the nuclei of non–germ cell tumors is theoretically diagnostic. More widespread use of a newly available NUT immunohistochemical stain will facilitate the diagnosis of NUT rearranged carcinomas. From the growing numbers of identified cases, effective targeted therapies can be developed.
Assessment of Latent Factors Contributing to Error: Addressing Surgical Pathology Error Wisely
Authors: Smith Maxwell L. , Raab Stephen S. 
Published: October 2011

Context.—Methods to improve surgical pathology patient safety include measuring the frequency of error in specific steps of the surgical pathology testing process, root cause analysis of active and latent components, and implementation of quality improvement initiatives.Objective.—To determine the frequency and cause of near-miss events in the specimen accessioning, setup, and biopsy-only gross examination testing steps of anatomic pathology.Design.—We used an observational checklist method to identify near-miss events. We performed root cause analysis to determine latent factors contributing to near-miss events. We conducted observations for 45 hours during 5 days, involving the accessioning and processing of 335 specimens.Results.—We detected a total of 2310 process-dependent and 266 operator-dependent near-miss events, resulting in a near-miss–event frequency of 5.5 per specimen. Root cause analysis showed that all process and operator near-miss events were associated with multiple system latent factors, including lack of standardized protocols, appropriate knowledge transfer, and focus on safety culture.Conclusion.—We conclude that the increased focus on surgical pathology near-miss events will reveal latent factors that may be targeted for improvement.
Regulation of subchondral bone osteoblast metabolism by cyclic compression
Authors: Sanchez Christelle , Pesesse Laurence , Gabay Odile , Delcour Jean‐Pierre , Msika Philippe , Baudouin Caroline , Henrotin Yves E. 
Published: October 2011

AbstractObjectiveRecent data have shown that abnormal subchondral bone remodeling plays an important role in osteoarthritis (OA) onset and progression, and it was suggested that abnormal mechanical pressure applied to the articulation was responsible for these metabolic changes. This study was undertaken to evaluate the effects of cyclic compression on osteoblasts from OA subchondral bone.MethodsOsteoblasts were isolated from sclerotic and nonsclerotic areas of human OA subchondral bone. After 28 days, the osteoblasts were surrounded by an abundant extracellular matrix and formed a resistant membrane, which was submitted to cyclic compression (1 MPa at 1 Hz) for 4 hours. Gene expression was evaluated by reverse transcription–polymerase chain reaction. Protein production in culture supernatants was quantified by enzyme‐linked immunosorbent assay or visualized by immunohistochemistry.ResultsCompression increased the expression of genes coding for interleukin‐6 (IL‐6), cyclooxygenase 2, RANKL, fibroblast growth factor 2, IL‐8, matrix metalloproteinase 3 (MMP‐3), MMP‐9, and MMP‐13 but reduced the expression of osteoprotegerin in osteoblasts in both sclerotic and nonsclerotic areas. Colα1(I) and MMP‐2 were not significantly affected by mechanical stimuli. Nonsclerotic osteoblasts were significantly more sensitive to compression than sclerotic ones, but after compression, differences in messenger RNA levels between nonsclerotic and sclerotic osteoblasts were largely reduced or even abolished. Under basal conditions, sclerotic osteoblasts expressed similar levels of α5, αv, β1, and β3 integrins and CD44 as nonsclerotic osteoblasts but 30% less connexin 43, an important mechanoreceptor.ConclusionGenes involved in subchondral bone sclerosis are mechanosensitive. After compression, nonsclerotic and sclerotic osteoblasts expressed a similar phenotype, suggesting that compression could be responsible for the phenotype changes in OA subchondral osteoblasts.
Lack of an effect of anacetrapib on the pharmacokinetics of digoxin in healthy subjects
Authors: Krishna Rajesh , Stypinski Daria , Ali Melissa , Garg Amit , Gendrano Isaias Noel , Maes Andrea , DeGroot Bruce , Liu Yang , Li Susie , Connolly Sandra M. , Wagner John A. , Stoch S. Aubrey 
Published: October 2011

ABSTRACTAnacetrapib is currently being developed for the oral treatment of dyslipidemia. A clinical study was conducted in healthy subjects to assess the potential for an interaction with orally administered digoxin. Anacetrapib was generally well tolerated when co‐administered with digoxin in the healthy subjects in this study. The geometric mean ratios (GMR) for (digoxin + anacetrapib/digoxin alone) and 90% confidence intervals (CIs) for digoxin AUC0‐last and AUC0‐∞ were 1.05 (0.96, 1.15) and 1.07 (0.98, 1.17), respectively, both being contained in the accepted interval of bioequivalence (0.80, 1.25), the primary hypothesis of the study. The GMR (digoxin + anacetrapib /digoxin alone) and 90% CIs for digoxin Cmax were 1.23 (1.14, 1.32). Median Tmax and mean apparent terminal t½ of digoxin were comparable between the two treatments. The single‐dose pharmacokinetics of orally administered digoxin were not meaningfully affected by multiple‐dose administration of anacetrapib, indicating that anacetrapib does not meaningfully inhibit P‐glycoprotein. Thus, no dosage adjustment for digoxin is necessary when co‐administered with anacetrapib. Copyright © 2011 John Wiley & Sons, Ltd.
Randomized clinical trial of epidural, spinal or patient-controlled analgesia for patients undergoing laparoscopic colorectal surgery (Br J Surg 2011; 98: 1068–1078)
Authors: Stevens M F , de Nes L , Hollmann M W 
Published: October 2011

Abstract
The Editors welcome topical correspondence from readers relating to articles published in the Journal. Responses should be sent electronically via the BJS http://www.bjs.co.uk. All letters will be reviewed and, if approved, appear on the website. A selection of these will be edited and published in the Journal. Letters must be no more than 250 words in length.
Modeling the Presence of Humic Acid in Ultrafiltration of Xenobiotic Compounds: Elman Recurrent Neural Network
Authors: Ghaemi N. , Madaeni S. S. , Abolhasani M. , Zahedi G. , Rajabi H. 
Published: October 2011

AbstractPredicting the rejection of pesticides in ultrafiltration (UF) processes in the presence of common components of dissolved natural organic matter would be taken into consideration as a principle for surface water treatment. This paper presents the application of the Elman Recurrent Neural Network (ERNN) model, which has been trained with previously‐obtained experimental data so as to predict the rejection of a class of xenobiotic compounds (nitrophenols (NPs)) dynamically, in the absence and in the presence of humic acid at neutral and acidic conditions. For each trained network, the training function, number of neurons in the hidden and output layers, number of epochs, train and test MSE (mean square error) and MRE (mean relative error) were compared to find the best ERNN. The trained MRE and test MSE for all NPs at the neutral condition was, respectively, less than 1.03 % (4.9 % at acidic condition) and 2.4 % (2.01 % at acidic condition), which showed high network reliability.
Catalytic Oxidative Decomposition of Hydrazine in Vapor Phase over Nanosized Au/γ‐Al2O3
Authors: Pakdehi S. G. , Sohrabi M. 
Published: October 2011

AbstractThe catalytic activity of nanosized Au/γ‐Al2O3, synthesized by a deposition‐precipitation process, on oxidative decomposition of hydrazine in air is discussed. The catalyst exhibited an excellent activity at low temperatures. The activity was strongly dependent upon the gold cluster size. The impacts of certain pertinent operating parameters including the particle size of the catalyst, temperature, hydrazine concentration, and feed flow rate on the extent of the reaction were investigated. The results were reproducible with a mean absolute deviation of 3 %. Deactivation of the catalyst during the reaction was found to be unlikely. Finally, a kinetic model based on the Eley‐Rideal formulation was proposed for the reaction and a correlation was made between the data predicted from the model and those determined experimentally.
ChemInform Abstract: A Raman Spectroscopic Study of the XeOF4/XeF2 System and the X‐Ray Crystal Structure of α‐XeOF4·XeF2.
Authors: Hughes Michael J. , Brock David S. , Mercier Helene P. A. , Schrobilgen Gary J. 
Published: October 2011

AbstractThe interaction of XeF2 with excess XeOF4 leads to the formation of a mixture of α‐XeOF4·XeF2 and β‐XeOF4·XeF2.