bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discovery of Substituted 2-oxoquinolinylthiazolidin-4-one Analogues
as Potential EGFRK Inhibitors in Lung Cancer Treatment
Authors: Naik Soniya , Soumya Vasu , Mamledesai Shivlingrao N , Manickavasagam M , Choudhari Prafulla , Rathod Sanket 
Published: June 2024

Abstract
Purpose Cancer is the second leading cause of death globally and is
responsible for an estimated 9.6 million deaths in 2018. Globally, about 1 in 6
deaths is due to cancer and the chemotherapeutic drugs available have high
toxicity and have reported side effects hence, there is a need for the synthesis
of novel drugs in the treatment of cancer.
Methods The current research work dealt with the synthesis of a series of
3-(3-acetyl-2-oxoquinolin-1-(2H)-yl-2-(substitutedphenyl)thiazolidin-4-one
(Va-j) derivatives and evaluation of their in-vitro anticancer activity.
All the synthesized compounds were satisfactorily characterized by IR and NMR
data. Compounds were further evaluated for their in-vitro anticancer
activity against A-549 (lung cancer) cell lines. The in-vitro
anticancer activity was based upon the
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide (MTT) assay
method.
Results The synthesized compounds exhibited satisfactory anticancer
properties against the A-549 cell line. The compound (Vh) showed the
highest potency amongst the tested derivatives against the A-549 cell
line with IC50 values of 100 µg/ml respectively and was also found to
be more potent than Imatinib (150 µg/ml) which was used as a standard drug.
Molecular docking studies of the titled compounds (Va-j) were carried out using
AutoDock Vina/PyRx software. The synthesized compounds exhibited well-conserved
hydrogen bonds with one or more amino acid residues in the active pocket of the
EGFRK tyrosine kinase domain (PDB 1m17).
Conclusion Among all the synthesized analogues, the binding affinity of
the compound (Vh) was found to be higher than other synthesized derivatives and
a molecular dynamics simulation study explored the stability of the docked
complex system.
Bereit für die Betreuung von Schwangeren mit Beckenendlage? –
Ergebnisse aus einer Onlinebefragung für Hebammen und werdende Hebammen in
Deutschland, Österreich und der Schweiz
Authors: Friedrichsohn Berit K. , Bauch Sebastian A. , Starrach Teresa , Pflanz Mira , Pecks Ulrich , Buechel Johanna 
Published: June 2024

ZusammenfassungDie vaginale Geburt aus Beckenendlage (BEL) ist eine Option für Gebärende, die
auch von den aktuellen deutschen und internationalen Leitlinien unterstützt
wird, wenn günstige Bedingungen und entsprechend ausgebildetes Personal
vorhanden sind. Laut Hebammengesetzen in der D-A-CH-Region sollen Hebammen im
Notfall die Betreuung einer vaginalen BEL-Geburt leisten können. Daher ist das
Vermitteln von Skills zur BEL-Geburt in der Ausbildungsordnung werdender
Hebammen festgeschrieben. Im Rahmen dieser Studie wurde das Wissen sowie der
Trainingsbedarf von Hebammen und werdenden Hebammen im deutschsprachigen Raum
evaluiert. Hierfür wurden im Mai 2022 mittels einer Onlinebefragung die
bisherigen Erfahrungen, das spezifische Wissen und der weitere
Fortbildungsbedarf von Hebammen und Hebammen in Ausbildung bezüglich der
vaginalen BEL-Geburt erhoben. Die Auswertung von 467 Fragebögen zeigte, dass nur
30% der Befragten in ihrem aktuellen beruflichen Umfeld vaginale BEL-Geburten
betreuen, aber 50% der Befragten dies gerne anbieten würden. 94% der Befragten
gaben an, sich sicherer zu fühlen, wenn regelmäßige Fortbildungsmöglichkeiten,
insbesondere Simulationen und virtuelle Angebote, zur vaginalen BEL-Geburt
angeboten werden würden. Aktuell erhalten jedoch nur 10% der Befragten ein
regelmäßiges Fortbildungsangebot für vaginale BEL-Geburten. Die Ergebnisse
zeigen, dass vermehrt Fortbildungen und Trainingsmöglichkeiten zur vaginalen
BEL-Geburt angeboten werden sollten, um die Sicherheit von Hebammen im Umgang
mit vaginalen BEL-Geburten zu erhöhen.
Therapeutic Potential of Pentoxifylline in Paraquat-Induced Pulmonary
Toxicity: Role of the Phosphodiesterase Enzymes
Authors: Ghasemi Farshad , Mohammadi Mobina , Ghaffari Fatemeh , Hosseini-Sharifabad Ali , Omidifar Navid , Nili-Ahmadabadi Amir 
Published: June 2024

AbstractPentoxifylline (PTX), a non-selective phosphodiesterase inhibitor, has
demonstrated protective effects against lung injury in animal models. Given the
significance of pulmonary toxicity resulting from paraquat (PQ) exposure, the
present investigation was designed to explore the impact of PTX on PQ-induced
pulmonary oxidative impairment in male mice.Following preliminary studies, thirty-six mice were divided into six groups.
Group 1 received normal saline, group 2 received a single dose of PQ (20 mg/kg;
i.p.), and group 3 received PTX (100 mg/kg/day; i.p.). Additionally, treatment
groups 4–6 were received various doses of PTX (25, 50, and 100 mg/kg/day;
respectively) one hour after a single dose of PQ. After 72 hours, the animals
were sacrificed, and lung tissue was collected.PQ administration caused a significant decrease in hematocrit and an increase in
blood potassium levels. Moreover, a notable increase was found in the lipid
peroxidation (LPO), nitric oxide (NO), and myeloperoxidase (MPO) levels, along
with a notable decrease in total thiol (TTM) and total antioxidant capacity
(TAC) contents, catalase (CAT) and superoxide dismutase (SOD) enzymes activity
in lung tissue. PTX demonstrated the ability to improve hematocrit levels;
enhance SOD activity and TTM content; and decrease MPO activity, LPO and NO
levels in PQ-induced pulmonary toxicity. Furthermore, these findings were
well-correlated with the observed lung histopathological changes.In conclusion, our results suggest that the high dose of PTX may ameliorate lung
injury by improving the oxidant/antioxidant balance in animals exposed to
PQ.
Training in Sylvian Arachnoid Dissection: The Art of Using Kamiyama Scissors and a Simple Novel Model for Practice Sylvian Arachnoid Dissection Using Cotton Fiber with Brain Model
Authors: Ariyaprakai Chanon , Kusdiansah Muhammad , Degollado-García Javier , Ota Nakao , Noda Kosumo , Kamiyama Hiroyasu , Tanikawa Rokuya 
Published: June 2024

Abstract
Background Transsylvian approach is one of the main approaches for a variety of vascular, tumor, and skull-base lesions. Sylvian fissure harbors a lot of critical structures including the middle cerebral artery and many venous structures. If not done properly, the transsylvian approach could cause several complications. Up to now, there is no simple training model for practicing Sylvian fissure dissection. In this article, we describe the technique of using microscissors for the sharp dissection of arachnoid trabeculae. We also propose a new model for practicing Sylvian arachnoid dissection using a three-dimensional (3D) brain model with cotton fiber.
Materials and Method We inserted cotton fiber into the Sylvian fissure of the brain model (aneurysm box from UpsurgeOn) and covered the Sylvian fissure with a cotton sheet, then sprayed the water over it. We dissected this model under a microscope by using Kamiyama scissors in the right hand and suction in the left hand.
Result Under the microscope, our model appears comparable with the real Sylvian fissure. We can use this model for practicing arachnoid dissection with Kamiyama scissors.
Conclusion The arachnoid dissection model by using a 3D brain model with cotton fiber is a simplified and novel approach for practicing the Sylvian fissure dissection.
Pragmatism and protest: Russia’s communist party through Covid-19 and beyond
Authors: Blackburn Matthew , Hutcheson Derek S. 
Published: June 2024

AbstractThe Covid-19 epidemic came at a sensitive time for Russia’s leadership, which was attempting a political reset and structural reforms, including the removal of President Putin’s presidential term limits. This article examines how issues related to the pandemic provided new opportunities for the systemic opposition, the Communist Party of the Russian Federation, who emerged as the main beneficiaries after capitalising on opportunities created by the epidemic. The underappreciated role of systemic opposition parties in electoral authoritarian systems, which balance “voice” and “loyalty” to benefit both themselves and the regime, is examined in the context of the Covid-19 crisis.
Bitcoin’s bubbly behaviors: does it resemble other financial bubbles of the past?
Authors: Náñez Alonso Sergio Luis , Jorge-Vázquez Javier , Echarte Fernández Miguel Ángel , Sanz-Bas David 
Published: June 2024

AbstractA number of financial bubbles have occurred throughout history. The objective of this study was to identify the main similarities between Bitcoin price behavior during bubble periods and a number of historical bubbles. Once this had been carried out, we aimed to determine whether the solutions adopted in the past would be effective in the present to reduce investors’ risk in this digital asset. This study brings a new approach, as studies have previously been conducted analyzing the similarity of Bitcoin bubbles to other bubbles individually, but these were not conducted in such a broad manner, addressing different types of bubbles, and over such a broad time period. Starting from a dataset with 9967 records, a combined methodology was used. This consisted of an analysis of the standard deviations, the growth rates of the prices of the assets involved, the percentage increase in asset prices from the origin of the bubble to its peak and its fundamental value, and, finally, the bubble index. Lastly, correlation statistical analysis was performed. The results obtained from the combination of the above methods reveal the existence of certain similarities between the Bitcoin bubbles (2011, 2013, 2017, and 2021) and the tulip bubble (1634–1637) and the Mississippi bubble (1719–1720). We find that the vast majority of the measures taken to avoid past bubbles will not be effective now; this is due to the digital and decentralized nature of Bitcoin. A limitation of the study is the difficulty in making a comparison between bubbles that occurred at different historical points in time. However, the results obtained shed light and provide guidance on the actions to be taken by regulators to ensure the protection of investors in this digital asset.
A compact quad-square negative-index metamaterial: Design, simulation, and experimental validation for microwave applications
Authors: Khalil Muhammad Amir , Yong Wong Hin , Hoque Ahasanul , Islam Md. Shabiul , Chiong Lo Yew , Chin Leei Cham , Alzamil Ahmed , Islam Mohammad Tariqul 
Published: June 2024

This research provides a detailed explanation of the design, simulation, and experimental of quad-square metamaterial-based negative-index unit cells for S-band applications. The Computer Simulation Technology 2022 licensee version was utilized to design and obtain numerical results for the unit cell. The proposed unit cell for the metamaterial has dimensions of 5 × 5 × 1.57 mm3. The substrate chosen was FR-4, resulting in a substantial effective medium ratio value of 19.07. A series of systematic parametric studies were conducted to optimize the quad square metamaterial structure. Key parameters, such as substrate types, unit cell arrays, thicknesses of substrate, and split gaps, were varied to determine their impact on the structure. The validated equivalent circuit result was compared to the simulated results, showing a significant agreement. The demonstrated correlation between simulation and experimental data highlights the dependability of the proposed quad-square metamaterial, positioning it as a viable option for a range of electromagnetic applications, such as communication systems, sensors, and imaging devices.
Reliability inference based on inverted exponentiated Rayleigh lifetime distribution under unified hybrid censored scheme
Authors: Tashkandy Yusra A. , Hasaballah Mustafa M. , Bakr M. E. , Balogun Oluwafemi Samson , Ramadan Dina A. 
Published: June 2024

In this study, we investigated the Inverted Exponentiated Rayleigh Distribution (IERD), a significant and efficient continuous lifetime distribution commonly applied in lifespan research. Our focus was on estimating unknown parameters for a two-parameter inverted exponentiated Rayleigh distribution using unified hybrid censored data. We considered both maximum likelihood and Bayesian estimation approaches. Specifically, we employed the Gibbs within Metropolis–Hastings samplers method to develop approximate Bayes estimators utilizing informative and non-informative priors, along with symmetric and asymmetric loss functions. In addition, we utilized Markov chain Monte Carlo (MCMC) samples to derive maximum posterior density credible intervals. Simulation experiments were conducted to assess the efficacy of the proposed methodologies, and actual data analysis was performed to validate the proposed estimators.
Multiferroic neuromorphic computation devices
Authors: Lu Guangming , Salje Ekhard K. H. 
Published: June 2024

Neuromorphic computation is based on memristors, which function equivalently to neurons in brain structures. These memristors can be made more efficient and tailored to neuromorphic devices by using ferroelastic domain boundaries as fast diffusion paths for ionic conduction, such as of oxygen, sodium, or lithium. In this paper, we show that the local memristor generates a second, unexpected feature, namely, weak magnetic fields that emerge from moving ferroelastic needle domains and vortices. The vortices appear near ferroelastic “junctions” that are common when the external stimulus is a combination of electric fields and structural phase transitions. Many ferroelastic materials show such phase transitions near room temperatures so that device applications display a “multiferroic” scenario where the memristor is driven electrically and read magnetically. Our computer simulation study of an elastic spring model suggests magnetic fields in the order of 10−7 T, which opens the way for a fundamentally new way of running neuromorphic devices. The magnetism in such devices emerges entirely from intrinsic displacement currents and not from any intrinsic magnetism of the material.
On the co-optation of according to
as an evidential in English
Authors: Ziegeler Debra 
Published: June 2024

Abstract
The use of according to + NP has rarely been the topic of any specialized research in relation to
English evidentiality, although it would probably figure among the most frequent types of reportative evidentials found in written
texts. One of the problems often associated with reportatives has related to the existence of the Reportative Exception (see, e.g.
AnderBois 2014), referring to the fact that the speaker may not always subjectively
endorse the proposition conveyed with the support of the evidential phrase. The present study reviews the history of
according to + NP from Middle English onwards, after which it began to develop evidential functions, and
shows how the tendency to reject the truth of the content of the proposition marked by according to + NP arose in
specific contexts containing alternative information sources, comparison, or adversative clauses. It was shortly after the
diachronic appearance of according to + NP in such contexts that the more periphrastic form, in
accordance with + NP, began to renovate/renew the earlier, non-evidential meanings of according to +
NP. The present study also attributes the development of according to + NP to a process of co-optation (e.g.
Heine 2013) rather than grammaticalization.
“Resident superhero”
Authors: Mullan Kerry 
Published: June 2024

Abstract
Situated at the intersection of social media communication and pragmatics of language use online, this article
will examine the social action of community veneration of a local plumber by members of a neighbourhood Facebook group, the vast
majority of whom do not know each other personally (nor necessarily the plumber). Particular attention will be paid to the way in
which this veneration is constructed over time through linguistic creativity and humour, such as limericks, exaggeration, and
various terms of reverence and hero worship. In addition to these linguistic devices, it will be shown how the participants
actively exploit the digital environment to create context-dependent humour through emojis, memes, and other graphics. The
selected examples will illustrate how this collaborative veneration and playfulness also strengthen the sense of belonging in this
group of online strangers.
Cooling of an object by forced convection
Authors: Dutra Mateo , Monteiro Martín , Martí Arturo C 
Published: June 2024

Abstract
We present an experiment on forced convection where a previously heated object is cooled under the effect of a controlled stream of air. We consider a square copper plate in which temperature variations can be considered negligible and we measure the cooling rate as a function of the average velocity of the air stream. We use a thermal camera to measure the temperature field and the cooling curves as a function of time for different conditions. An empirical relation between the characteristic cooling time and the mean velocity of the air stream is reported. The results obtained are discussed in the framework of simple dimensional models and their limits of validity.
Electric-field-controlled electronic structures and quantum transport in monolayer InSe nanoribbons
Authors: Ye Qian , Tang Shunxi , Du Yan , Liu Zhengfang , Wu Qingping , Xiao Xianbo 
Published: June 2024

Abstract
Electronic structures and quantum transport properties of the monolayer InSe nanoribbons are studied by adopting the tight-binding model in combination with the lattice Green function method. Besides the normal bulk and edge electronic states, a unique electronic state dubbed as edge-surface is found in the InSe nanoribbon with zigzag edge type. In contrast to the zigzag InSe nanoribbon, a singular electronic state termed as bulk-surface is observed along with the normal bulk and edge electronic states in the armchair InSe nanoribbons. Moreover, the band gap, the transversal electron probability distributions in the two sublayers, and the electronic state of the topmost valence subband can be manipulated by adding a perpendicular electric field to the InSe nanoribbon. Further study shows that the charge conductance of the two-terminal monolayer InSe nanoribbons can be switched on or off by varying the electric field strength. In addition, the transport of the bulk electronic state is delicate to even a weak disorder strength, however, that of the edge and edge-surface electronic states shows a strong robustness against to the disorders. These findings may be helpful to understand the electronic characteristics of the InSe nanostructures and broaden their potential applications in two-dimensional nanoelectronic devices as well.
The funneling effect in a non-Hermitian Anderson model
Authors: Turker Z , Yuce C 
Published: June 2024

Abstract
The topological funneling effect, i.e., the motion of an arbitrary excitation to a focal point of the lattice no matter where the lattice is excited, is a dynamical effect due to the non-Hermitian skin effect. This effect disappears in the presence of strong disorder where the system is topologically trivial. In Anderson localized regime with complex spectrum, the motion shows jumpy behavior and the focal point can be any point along the lattice as it is not possible to say its exact place in an experiment a priori. We study transport phenomena in a non-Hermitian system, exhibiting both funneling effect and non-Hermitian jumps. We show that the competition between the skin and Anderson localizations may result in the creation of an extended eigenstate. This can lead to disorder-induced dynamical delocalization in topologically nontrivial region.
A generalized analytical viscous model for steady-state atmospheric vortices
Authors: Yadav Kriti , Prasad Maurya Jagdish , Kumar Pandey Sanjay 
Published: June 2024

Abstract
This paper presents a generalised analytical viscous model for atmospheric vortices. All the velocity components are dependent on radial and axial coordinates. The model begins with radial velocity derived by Onishchenko et al (2021). Other components are derived from the governing equations. Rankine (1882) and Burgers (1948) models are used as the boundary condition for imposing cyclostrophic balance. All the velocity components of this model are bounded. The radial pressure is also deduced. Radial profiles of axial, azimuthal velocities and radial pressure are plotted. The azimuthal velocity derived with the Rankine model as the boundary condition shows a sharp turn at the core layer where it is maximum and increases with height, while the changes are smooth near the core and not necessarily maximum at the core for the Burgers boundary condition. The azimuthal component of velocity increases at lower altitudes but declines at higher ones. It shows a reverse trend in the inner and the outer regions close to the core radius. Further, radial velocity reduces in magnitude with height. In both cases, radial pressure is higher in the outer region but lessens gradually in the core to vanish at the axis. It also increases with height.
Cladding-free Fermi arc surface states and topological directional couplers in ideal photonic Weyl metamaterials
Authors: Li Mingzhu , Han Ning , Wang Yiran , Chai Yan , Zhao Rui , Qi Lu , Liu Shutian 
Published: June 2024

Abstract
Photons can freely propagate in a vacuum, making it not a simple insulator but rather a conductor for photons. Consequently, in topological photonics, domain wall structures with opposing effective mass terms are used as cladding to confine electromagnetic waves. This approach is necessary to demonstrate topological edge/surface waves and Fermi arc surface states (FASS). Here, we show that the cladding-free FASS with high field localization at the boundary can be achieved using ideal Weyl gyromagnetic metamaterials (GMs). In these GMs, the ideal Weyl semimetal phase exists due to the dispersionless longitudinal modes. At the boundary of the GMs-vacuum system, the cladding-free FASS connects the projections of Weyl nodes with opposite chirality, thanks to the bulk-boundary correspondence principle. We further confirm that chiral boundary modes can propagate without experiencing scattering or backward reflection, i.e., they can advance seamlessly approximately various types of defects. Remarkably, various types of topological directional couplers are achieved by utilizing cladding-free FASS in an ideal gyromagnetic medium. Our theoretical analysis reveals that the underlying operational principle for accomplishing these nonreflecting directional couplers is due to the single coupling channel between the cladding-free FASS and the multi-type scatterers of the continuous media. Furthermore, the controllable propagation and topological directional coupling of cladding-free FASS can be further explored by adjusting the ideal gyromagnetic medium and boundary configurations of the continuous media system. This research offers increased flexibility for the development of cladding-free and directionally coupled topological devices.