bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrophysiological Demonstration of Motor Reorganization in Healthy Hemispheres of Patients with Intractable Epilepsy due to Early Unilateral Brain Damage
Authors: İşler Cihan , Taşkıran Emine , Baş Gülçin , Türk Bengi Gül , Özkara Çiğdem , Uzan Mustafa 
Published: April 2024

Abstract

Background: The functional reorganization of motor functions is a sign of adaptive brain plasticity to brain damage and understanding its mechanisms may be a key role to many treatment models for brain damage in childhood and even in adults. Our aim is to show an electrophysiological evidence of brain plasticity regarding motor functions in early brain damaged patients.
Methods: We retrospectively analyzed four patients with some extremity motor functions shifting to unusual brain areas who were diagnosed with childhood epilepsy and underwent epilepsy surgery. We analyzed their clinical and surgical data particularly including intraoperative neuromonitorization (IONM) results.
Results: Patients’ preoperative data showed some motor representation of extremities was located somewhere else than the expected brain areas due to perinatal damage. In first patient right hand presentation was shifted to the right hemisphere and in second patient right hand was represented on both hemispheres. In the remaining two patients, all the motor functions of epileptogenic hemisphere were shifted to the contralateral side. IONM proved the neuroplasticity of the patients with previously crossed motor functions and was in line with preoperative functional Magnetic Resonance Imaging data.
Conclusion: Brain plasticity can alter the motor reorganization of the healthy hemisphere by taking upon the functions of the pathological hemisphere.
With or without the parties' presence within the court-administrative procedure? Lessons from Poland.
Authors: Piątek Wojciech , Joński Kamil 
Published: April 2024

Abstract

Courts` disputes in contemporary jurisdictions are heard either with parties` participation – physical or remote - or in-camera, without any forms of orality. The article is aimed at examining the consequences of the case forum for a judgment before the Polish First Instance Administrative Courts (FIACs). We will explore if there are any connections between the parties` presence or absence during proceedings for the probability of the complainant’s winning, the time required to adjudicate the case in the first instance, and the probability of appeal to the Supreme Administrative Court (SAC). A basis for the research is a full-text database of the universe of first and second-instance judgments of Polish Administrative Courts (CBOSA) with all judgments issued by FIACs over 2016–2022, embracing a sample of nearly 250 thousand judgments. The research design is based on the COVID-19 pandemic outbreak, which caused a shift from physical hearings to in-camera adjudication. The pandemic changed the preferences of parties towards in-camera deliberation and provoked legislative changes promoting in-camera adjudication. The results indicate that compared to hearings, in-camera adjudication shortened the time to adjudicate the case. This shift was beneficial for shortening the time to adjudicate the case. Although we found a statistically significant effect of in-camera adjudication on the probability of compliant winning in the first instance (negative) and appealing to SAC (negative) the size of the effects remains small.
A cost-saving, picture-assisted method for toric intraocular lens alignment versus manual self-leveling marking via RoboMarker
Authors: Kiessling David , Roessler Gernot F. , Widder Randolf A. 
Published: April 2024

Abstract

Purpose: To determine the accuracy of two axis-marking methods for toric intraocular lens (IOL) implantation, one picture-assisted approach based on scleral vessel vectors, and the other based on a self-leveling device for manual marking.
Methods: This retrospective single-center study involved 60 eyes of 51 participants, who underwent phacoemulsification with toric IOL implantation. In all eyes, preoperative markings were made in a seated position both manually via a self-leveling corneal marker (RoboMarker), and digitally on slit-lamp photographs, defining scleral vessels as landmarks, aiding to find the correct intraoperative orientation for an angular graduation instrument.
The axis of IOL alignment at the end of surgery was determined from high resolution, intraoperative footage from a microscope-integrated camera and the axis-marking error served as an outcome measurement for both marking techniques. The endpoint was the alignment of the lens at the end of surgery.
Results: The average axis-marking error was 2.5 ±1.9 degrees for picture-assisted marking, which was significantly less than that of the self-leveling corneal marker, being 5.4 ±4.4 degrees.
Conclusion: Our results indicate that scleral vessel vector marking leads to highly accurate toric IOL alignments, while being an inexpensive technique, as solely a slit-lamp camera is required for preoperative preparation.
Implicit identification is associated with self-injury severity among clinically diagnosed adolescents with NSSI
Authors: Liang Meng , Xu Huijing , Gao Qi , Jiang Qian , Yuan Aihua , Sun Jinhua , Liu Taosheng 
Published: April 2024

Abstract

Background
Compared to the general adolescent population, adolescents with a clinical diagnosis of NSSI tend to have more severe psychological problems and their self-injurious behaviors tend to be more severe. The positive feedback between implicit identification and self-harm may be more pronounced in this population than in the general population.
Methods
A total of 100 adolescent patients diagnosed with NSSI at the Department of Psychology, Shanghai Changzheng Hospital and the Psychological Medicine Clinic, Children's Hospital, Fudan University were prospectively recruited into the study. The SI-IAT was completed by each patient to assess his or her implicit identification with NSSI. The relationship between implicit identification and the severity of self-injury among these patients was analyzed.
Results
The study found that patients in the severe NSSI group had significantly higher D-scores than those in the mild NSSI group (0.849 [0.274, 1.541] vs. 0.361 [-1.001, 0.872], p = 0.003). Logistic regression analysis revealed that D-score had an independent influence on the severity of NSSI (OR = 3.201, p = 0.004).
Conclusion
Implicit identification had an independent influence on the severity of self-injury in clinically diagnosed NSSI adolescent patients. Research on implicit identification about self-injury may be beneficial for the prevention and intervention of NSSI.
Scientific Analysis of the Gilt-Bronze Chariot Parasol Component of the Eastern Han Dynasty Excavated from the Dafenbao Cemetery, Pengshan, Sichuan, China
Authors: LIANG CHENXI , Li Wantao , Yu Xiaohong , Li Yuniu 
Published: April 2024

Abstract

Herein, the gilt-bronze Gaigongmao (chariot parasol component) were excavated in the Dafenbao cemetery, Pengshan county, Sichuan province, China. The function and the usage of the chariot parasol component have been inferred in this paper, and the virtual restoration pictures were diagramed. The samples were characterized by combining Ultra depth of field 3D microscope, ART-FTIR, SEM-EDS, element mapping, and wood species identification. The fibers around the Gaigongmao were detected as cotton threads, and the woods inside was bamboo, thus, the type of the parasol was presumed to be the San type. The gilding technology of the gilt-bronze was resulted for traditional mercury amalgam technology, and the traditional “Yaguang” technic can be observed in the SEM images. By comparing with the other data, the lead isotope date of the Gaigongmao was found falling within the range of the Yangtze River basin.
Designing biodegradable and antibacterial cellulose-based superhydrophobic packaging materials via large-scale self-assembly
Authors: Li Qiang , Jiang Xiaofan , Huang Mingjun , Lv Jiachen , Ling Zhe , Wang Songlin , Chen Fushan , Ji Zhe 
Published: April 2024

Abstract

Unbiodegradable petroleum-based packaging materials have posed a significant threat to the environment and human health, forcing urgent exploration of alternatives. Inspired by the charge-secreting layer of Sandcastle worm and the asymmetric wettability of lotus leaf, we successfully designed a dual biomimetic cellulose-based packaging material (CW@(CT)10) by an electrical charge-controlled layer-by-layer self-assembly of chitosan and TiO2 nanoparticles. The material achieved commendable mechanical properties and abrasion resistance, rendering it highly stable and durable. Benefit from the rough surface with nanostructures and low surface energy, the CW@(CT)10 showed a high water contact angle of 152.14°. The superhydrophobic surface reduced the bacterial adhesion, which integrated with the electropositivity of chitosan, endowing the materials with a 100% antibacterial ability to Staphylococcus aureus and Escherichia coli. Fruit antimicrobial tests and degradation studies in the natural environment demonstrated that CW@(CT)10 kept fruit bacteria-free for 5 days and exhibited completely biodegradable within 100 days. Notably, this work introduced a facile strategy for scalable production of a sustainable, inexpensive, durable, and environmentally friendly materials, showcasing immense potential applications in food packaging.
Additive impact of diabetes and Helicobacter pylori infection on all-cause mortality, diabetic mortality, and cardiovascular mortality: A longitudinal nationwide population-based study
Authors: Zeng Di , Zeng Qingyue , Wang Shaofeng , Li Shuangqing 
Published: April 2024

Abstract

Background Diabetes mellitus (DM) and Helicobacter pylori infection (HPI) pose increasing public health challenges in aging societies, sharing common pathophysiological mechanisms, and linked to significant health risks. Our study examines their respective impacts on all-cause and cardiovascular mortalities in a comprehensive longitudinal population-based analysis.Methods The study analyzed data from the National Health and Nutrition Examination Survey (NHANES) database conducted between 1999 and 2019, which included information on Diabetes mellitus status and Helicobacter pylori infection status. Mortality data were obtained from the same database mentioned above.Results Among the 2719 participants, 1362 (50.1%) were free of both diabetes mellitus (DM) and Helicobacter pylori infection (HP) (DM−/HP−), 140 (5.1%) had DM alone (DM+/HP−), 1011 (37.2%) had HP alone (DM−/HP+), and 206 (7.6%) had both DM and HP (DM+/HP+). Compared to the DM− /HP − group, the DM+ /HP − and DM+/HP + groups demonstrated increased all-cause mortality with adjusted hazard ratios (HRs) of 1.48 (95% [CI]: 1.17–1.88) and 1.56 (95% CI: 1.25–1.95), respectively. For diabetic mortality, DM+/HP- group and DM+/HP + group showed increased HR of 6.83 (95% CI: 1.36–34.36) and 9.17 (95% CI: 2.11–39.88), respectively. For cardiovascular mortality, the DM+/HP- group and DM+/HP + group exhibited increased HR of 1.73 (95% CI: 1.13–2.63) and 2.02 (95% CI: 1.37–2.97), respectively. The DM+/HP + cohort displayed the highest risk of overall mortality (p for trend = 0.003), diabetic mortality (p for trend < 0.0001), and cardiovascular mortality (p for trend < 0.0001).Conclusions The concurrent presence of DM and Helicobacter pylori infection significantly amplifies the risk of all-cause, cardiovascular, and diabetic mortality. Individuals with either condition may necessitate heightened management to prevent the onset of the other ailment and reduce mortality rates.
Histone deacetylase is dysregulated in mesenchymal stromal cells in Philadelphia-negative myeloproliferative neoplasms and functions as potential drug targets
Authors: Zhao Miaomiao , Wu Yaogong , He Wenjuan , Hu Min , Xue Mei , He Jing , Ge Renying , Zhang Min 
Published: April 2024

Abstract

Background:Previous studies imply that bone marrow-derived mesenchymal stromal cells (BM-MSCs) supports the progression of Philadelphia-negative myeloproliferative neoplasms (MPN). Histone deacetylases (HDACs) are believed to be promising anti-cancer targets, but its expression characteristics and biological functions in BM-MSCs of MPN patients are unclear.Methods:BM-MSCs were isolated from healthy donors and patients with polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF). Transforming growth factor β1 (TGF-β1) was used to stimulate BM-MSCs, and the expression levels of α-smooth muscle actin (α-SMA), fibroblast activation protein-α (FAP), HDAC1, HDAC2, HDAC3, HDAC8 were detected by qPCR and Western blot. Chidamide was selected as a representative HDAC inhibitor to treat BM-MSCs, and the activation of mTOR pathway was evaluated by Western blot, and the viability of BM-MSCs was examined by flow cytometry.Results:α-SMA and FAP were highly expressed in BM-MSCs of the patients with MPN. HDAC1, HDAC2, and HDAC8 were up-regulated in BM-MSCs of the patients with PMF. TGF-β1 induced up-regulation of α-SMA and FAP, and activation of mTOR signaling in BM-MSCs, while this effect could be reversed by chidamide. Chidamide could also induce the apoptosis of BM-MSCs.Conclusions:Dysregulation of HDACs was involved in pathogenesis of Philadelphia-negative MPN, and HDAC inhibitor such as chidamide may be potential candidate to treat this kind of diseases.
P53 immunohistochemistry is an ideal surrogate marker for TP53 mutation and a predictor of early metastasis in breast cancer: Real-world analysis
Authors: Lee Hyunwoo , Cho Yoon Ah , Kim Deok Geun , Son Jae Young , Cho Eun Yoon 
Published: April 2024

Abstract

Purpose: TP53 mutation in breast cancer (BC) is associated with chemoresistance, endocrine resistance, and late recurrence, resulting in poor prognosis. Nuclear accumulation of p53 in immunohistochemistry (IHC) is a surrogate marker of TP53 mutation. We analyzed the frequency, type, and distribution of TP53 mutations in BCs and assessed the efficacy of p53 IHC as a surrogate marker of TP53 mutation.
Methods: We collected 112 BC cases with the results of p53 IHC and next-generation sequencing (NGS).
Results: Overexpression of p53 IHC was observed in 36 (32.1%), complete absence in 19 (17.0%), aberrant cytoplasmic staining in 1 (0.9%), and wild-type in 56 (50.0%) patients. The concordance rate of TP53mutation and p53 IHC was 88.4% in all BCs, 89.9% in luminal BC, and 86.0% in triple-negative BC (TNBC). TNBC, abnormal p53 IHC pattern, p53 IHC overexpression, neoadjuvant chemotherapy (NAC) history, TP53mutation, and high pre-treatment ki-67 labeling index (≥ 50%) were significantly associated with worse distant metastasis free survival (DMFS) and overall survival (OS) (p < 0.05). Pre-NAC clinical stage III was associated with worse DMFS but not OS. Multivariate analysis results showed history of NAC, TNBC, or p53 IHC overexpression as independent predictors of worse DMFS. Abnormal p53 IHC pattern and NAC history were independent predictors of worse OS.
Conclusion: p53 IHC is a valid surrogate marker of TP53mutation of BC. Regardless of TP53 mutation, p53 IHC was associated with worse DMFS and OS and can be used as a biomarker to predict treatment resistance.
Lemierre's Syndrome: Atypical Presentation of the Internal Carotid Artery and Jugular Vein Fistula—CaseReport and Review
Authors: Kariuki Liza Wanjagi , Musabyemungu Jean Aime , kebedi Jemima , Shah Mitali , Hussein Fadhil , Ahmed Mohamednoor , Oburu Gilbert , Irungu Catherine , Kibaru Pauline , Ndiritu Simon , Omulo Tom 
Published: April 2024

Abstract

Background: Lemierre's syndrome (LS) is a rare yet potentially life-threatening complication of oropharyngeal infections that is typically characterized by septic thrombophlebitis of the internal jugular vein and is commonly associated with Fusobacterium necrophorum. Despite its recognition since 1936, LS can present atypically, as seen in our case where a patient exhibited a rare complication of an internal carotid artery and jugular vein fistula. This case highlights the diagnostic and therapeutic challenges that can arise and underscores the importance of both a broader awareness of LS and the necessity for a multidisciplinary approach.
Case Presentation: A 42-year-old male who was initially diagnosed with a periodontal abscess and tonsillitis later developed internal jugular vein thrombophlebitis. This progressed to an internal carotid to internal jugular vein fistula, leading to septic thrombosis of the left internal carotid and jugular vein and eventually culminating in a carotid bulb aneurysm and subsequent cerebral infarct. The patient also experienced septic emboli, resulting in lung and mediastinal abscesses. Treatment involved intravenous antibiotics, anticoagulant therapy, and vascular repair, yielding a favorable outcome.
Conclusions: This case underscores the intricate nature of LS, showing its potential to progress to severe septic complications, including rare vascular issues and cerebral infarction. The diagnostic complexities and therapeutic interventions emphasize the critical importance of early identification, prompt diagnosis, and multidisciplinary management of LS to prevent life-threatening outcomes.
Human Umbilical Cord Mesenchymal Stem Cells promote tendon functional repair in a Collagenase-Induced Tendinopathy Model
Authors: Sun Xiangyi , Lin Zhiwei , Chen Jinyang , Wang Zhe , Zhu Guangqi , Long Ruchao , Yang Zhihua 
Published: April 2024

Abstract

Achilles tendon rupture is a common tendinopathy.We investigated the therapeutic effects of UC-MSCs on the inflammatory condition, and explored the preliminary mechanisms underlying their role in rabbit Achilles tendon repair.Tendon structure and functional recovery were evaluated through histological assessment, pathology, tissue hydroxyproline (Hyp) content measurement, and biomechanical testing.Then the inflammation and metabolic status of the extracellular matrix, along with potential mechanisms, were assessed through quantitative real-time polymerase chain reaction, enzyme-linked immunosorbent assay, and immunohistochemical staining.This study demonstrated the satisfactory ability of UC-MSCs transplantation to promote functional repair of tendon in a rabbit model of tendon diseases. The mechanisms involved include upregulation of Collagen I and Collagen III expression, inhibition of MMP-9, and enhancement of muscle fiber contraction through increased expression of troponin C (TnC), thereby improving the structural stability at the site of inflammation. We concluded that UC-MSCs hold promising potential as an enhancement strategy for MSC-based therapy in tendon diseases.
Ectoparasitas em morcegos (Mammalia: Chiroptera) e seus patógenos na região central de Rondônia, oeste da Amazônia brasileira
Authors: Júnior Leormando Fortunato Dornelas , Cunha Irineu Norberto , Jorge Felipe Rodrigues , Graciolli Gustavo , Bassini-Silva Ricardo , Jacinavicius Fernando Castro , Serpa Maria Carolina A. , Labruna Marcelo Bahia , Pessoa Felipe Arley Costa , Camargo Luís Marcelo Aranha 
Published: April 2024

Abstract

In Brazil, few people know that in the Tupi language bats are called ‘andirá’, ‘guandira’, or ‘guandiruçu’. The lack of knowledge about these animals is not restricted to these names but to the diversity of species, their biological complexity and their ecological importance. Bats (Chiroptera) are among the most diverse and geographically dispersed mammals. They are of great importance to the ecosystem, as pollinators, seed dispersers, and controllers of pests, and they are also hosts of several ectoparasites. Ectoparasites include a variety of arthropods, such as ticks (Ixodida), mites (Mesostigmata, Sarcoptiformes, and Trombidiformes), lice (Anoplura), fleas (Siphonaptera) and flies (Diptera), and their diet includes tissues and blood or other bodily fluids of bats. Bats are reservoirs of various disease-causing agents, many of them pathogenic to humans, such as bacteria of the genera Borrelia, Bartonella, Coxiella, Orientia and Rickettsia, as well as protozoa (among the most important, Leishmania spp. and Trypanosoma cruzi), viruses (the most important being rabies and Ebola) and fungi (Histoplasma and Crytococcus). This study was carried out in Monte Negro, Rondônia, and the occurrence of ectoparasites in bats was evaluated, as well as the bacteria of medical importance carried by these ectoparasites. Through a total of 69 nocturnal captures, 217 specimens of chiropterans representing 23 species and six families were sampled. A total of 592 specimens of ectoparasites were collected from the bats. Bacteria of the genus Bartonella were found in two species of bat flies (Trichobius joblingi and Strebla mirabilis). We report for the first time in Rondônia the argasid tick Ornithodoros hasei and its infection by a bacterium of the spotted fever group Candidatus Rickettsia wissemanii.
Grain quality attributes of an on-farm rice germplasm directly beneficial to the farming households
Authors: Jamjod Sansanee , Prom-u-thai Chanakan , Jaksomsak Pennapa , Lordkaew Sitichai , Rerkasem Benjavan 
Published: April 2024

Abstract

Local crop landraces remaining on-farm are readily accessible to those relying on them for their livelihoods, while also contributing to plant genetic resource conservation. Characterization of landraces commonly revolves around traits for deployment in breeding programmes, often overlooking their direct value to the farmers. Rice from the highlands of Northern Thailand, which lie within the centre of diversity of rice (Oryza sativa) and where the crop is predominantly planted with local varieties or landraces, was examined for the grain quality features with direct implications for the local population. Un-husked rice seed, provided by farmers belonging to 10 minority groups who grows rice largely for subsistence, mainly had large grain in contrast to the slender grain type common in the lowlands. The highland grown rice brings direct benefits to the local population with a higher dietary intake of Fe but not Zn. The highlands have also been identified as a rich source of pigmented rice germplasm and an environment favouring the production of premium quality purple rice with high anthocyanin content. On-farm experiments confirmed the effects of genotype and environment and G x E interaction on rice grain zinc and anthocyanin content. Information on the value of local crop germplasm directly beneficial to the local population should facilitate a more sustainable on-farm conservation efforts than rewards offered to the farmers from external funding.
Exploring palynological diversity of Some concrete Honey Bee Forage Plants in North-Eastern Himalayas, India
Authors: NEOG Prostuti , SINGH Sumit , PHUKAN Tridip , BHUYAN Mantu 
Published: April 2024

Abstract

Pollen taxonomy is required to compare the pollen in honey samples in melissopalynological studies. Pollen taxonomy, which involves classifying and identifying pollen grains, is crucial for various aspects of pollen study. The present study was undertaken from August 2023 to December 2023 in Jorhat district of Assam, India. The pollen morphology of 33 different flowering plant species belonging to 18 families have been carried out, and variations in shape, symmetry, exine structure sculpture, etc., have been found. In this study, 12.12% are tree species, 54.54% are herb species, and 33.33% are shrub species.