bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sexually transmitted infections, sexual life and risk behaviours of people living with schizophrenia: systematic review and meta-analysis
Authors: Aymerich Claudia , Pedruzo Borja , Salazar de Pablo Gonzalo , Madaria Lander , Goena Javier , Sanchez-Gistau Vanessa , Fusar-Poli Paolo , McGuire Philip , González-Torres Miguel Ángel , Catalan Ana 
Published: May 2024

BackgroundSexually transmitted infections (STIs), along with sexual health and behaviour, have received little attention in schizophrenia patients.AimsTo systematically review and meta-analytically characterise the prevalence of STIs and sexual risk behaviours among schizophrenia patients.MethodWeb of Science, PubMed, BIOSIS, KCI-Korean Journal Database, MEDLINE, Russian Science Citation Index, SciELO and Cochrane Central Register were systematically searched from inception to 6 July 2023. Studies reporting on the prevalence or odds ratio of any STI or any outcome related to sexual risk behaviours among schizophrenia samples were included. PRISMA/MOOSE-compliant (CRD42023443602) random-effects meta-analyses were used for the selected outcomes. Q-statistics, I2 index, sensitivity analyses and meta-regressions were used. Study quality and publication bias were assessed.ResultsForty-eight studies (N = 2 459 456) reporting on STI prevalence (including 15 allowing for calculation of an odds ratio) and 33 studies (N = 4255) reporting on sexual risk behaviours were included. Schizophrenia samples showed a high prevalence of STIs and higher risks of HIV (odds ratio = 2.11; 95% CI 1.23–3.63), hepatitis C virus (HCV, odds ratio = 4.54; 95% CI 2.15–961) and hepatitis B virus (HBV; odds ratio = 2.42; 95% CI 1.95–3.01) infections than healthy controls. HIV prevalence was higher in Africa compared with other continents and in in-patient (rather than out-patient) settings. Finally, 37.7% (95% CI 31.5–44.4%) of patients were sexually active; 35.0% (95% CI 6.6–59.3%) reported consistent condom use, and 55.3% (95% CI 25.0–82.4%) maintained unprotected sexual relationships.ConclusionsSchizophrenia patients have high prevalence of STIs, with several-fold increased risks of HIV, HBV and HCV infection compared with the general population. Sexual health must be considered as an integral component of care.
Evaluation of Metronomic Therapy as a Low-Cost, Sustainable, Standard-of-Care Option in Desmoid Fibromatosis: Real-World Data From a Tertiary Care Center in India
Authors: Bajpai Jyoti , Munot Pritesh , Kota Kishore , Gupta Gaurav , Gala Kunal , Gulia Aashish , Rekhi Bharat , Khanna Nehal , Shetty Nitin , Bhargava Prabhat , Srinivas Sujay , Ostwal Vikas , Patil Vijay , Noronha Vanita , Kulkarni Suyash , Laskar Siddharth , Prabhash Kumar , Chinnaswamy Girish , Gupta Sudeep , Banavali Shripad 
Published: May 2024

PURPOSE Desmoid fibromatosis (DF) is a locally aggressive tumor with low mortality but significant morbidity. There is a lack of standard of care, and existing therapies are associated with significant barriers including access, cost, and toxicities. This study aimed to explore the efficacy and safety of the metronomic therapy (MT) in DF in a large, homogenous cohort from India. PATIENTS AND METHODS This study involved histologically confirmed DF cases treated with MT comprising vinblastine (6 mg) and methotrexate (15 mg) both once a week, and tamoxifen (40 mg/m2) in two divided doses once daily between 2002 and 2018. RESULTS There were 315 patients with a median age of 27 years; the commonest site was extremity (142 of 315; 45.0%). There were 159 (50.1%) male patients. Of the 123 (39.0%) prior treated patients, 119 had surgery. Of 315 patients, 263 (83.5%) received treatment at our institute (MT—151, 77—local treatment, 9—tyrosine kinase inhibitor, and 26 were observed). Among the MT cohort (n = 163, 61.2%), at a median follow-up of 36 (0.5-186) months, the 3-year progression-free and overall survival were 81.1% (95% CI, 74.3 to 88.4) and 99.2% (95% CI, 97.6 to 100), respectively. There were 35% partial responses. Ninety-two patients (56.4%) completed 1-year therapy, which was an independent prognosticator ( P < .0001; hazard ratio, 0.177 [95% CI, 0.083 to 0.377]). MT was well tolerated. Predominant grade ≥3 toxicities were febrile neutropenia, 12 (7.4%) without any chemotoxicity-related death. The annual cost of MT was $130 US dollars. CONCLUSION The novel, low-cost MT qualifies as one of the effective, less toxic, sustainable, standard-of-care options for the treatment of DF with global reach and merits wide recognition.
European Society of Endocrinology and Endocrine Society Joint Clinical Guideline: Diagnosis and Therapy of Glucocorticoid-induced Adrenal Insufficiency
Authors: Beuschlein Felix , Else Tobias , Bancos Irina , Hahner Stefanie , Hamidi Oksana , van Hulsteijn Leonie , Husebye Eystein S , Karavitaki Niki , Prete Alessandro , Vaidya Anand , Yedinak Christine , Dekkers Olaf M 
Published: May 2024

Abstract
Glucocorticoids are widely prescribed as anti-inflammatory and immunosuppressive agents. This results in at least 1% of the population using chronic glucocorticoid therapy, being at risk for glucocorticoid-induced adrenal insufficiency. This risk is dependent on the dose, duration and potency of the glucocorticoid, route of administration, and individual susceptibility. Once glucocorticoid-induced adrenal insufficiency develops or is suspected, it necessitates careful education and management of affected patients. Tapering glucocorticoids can be challenging when symptoms of glucocorticoid withdrawal develop, which overlap with those of adrenal insufficiency. In general, tapering of glucocorticoids can be more rapidly within a supraphysiological range, followed by a slower taper when on physiological glucocorticoid dosing. The degree and persistence of HPA axis suppression after cessation of glucocorticoid therapy are dependent on overall exposure and recovery of adrenal function varies greatly amongst individuals. This first European Society of Endocrinology/Endocrine Society joint clinical practice guideline provides guidance on this clinically relevant condition to aid clinicians involved in the care of patients on chronic glucocorticoid therapy.
The Pattern of GH Action in the Mouse Brain
Authors: Menezes Filipe , Wasinski Frederick , de Souza Gabriel O , Nunes Amanda P , Bernardes Emerson S , dos Santos Sofia N , da Silva Fábio F A , Peroni Cibele N , Oliveira João E , Kopchick John J , Brown Rosemary S E , Fernandez Gimena , De Francesco Pablo N , Perelló Mario , Soares Carlos R J , Donato Jose 
Published: May 2024

Abstract
GH acts in numerous organs expressing the GH receptor (GHR), including the brain. However, the mechanisms behind the brain's permeability to GH and how this hormone accesses different brain regions remain unclear. It is well-known that an acute GH administration induces phosphorylation of the signal transducer and activator of transcription 5 (pSTAT5) in the mouse brain. Thus, the pattern of pSTAT5 immunoreactive cells was analyzed at different time points after IP or intracerebroventricular GH injections. After a systemic GH injection, the first cells expressing pSTAT5 were those near circumventricular organs, such as arcuate nucleus neurons adjacent to the median eminence. Both systemic and central GH injections induced a medial-to-lateral pattern of pSTAT5 immunoreactivity over time because GH-responsive cells were initially observed in periventricular areas and were progressively detected in lateral brain structures. Very few choroid plexus cells exhibited GH-induced pSTAT5. Additionally, Ghr mRNA was poorly expressed in the mouse choroid plexus. In contrast, some tanycytes lining the floor of the third ventricle expressed Ghr mRNA and exhibited GH-induced pSTAT5. The transport of radiolabeled GH into the hypothalamus did not differ between wild-type and dwarf Ghr knockout mice, indicating that GH transport into the mouse brain is GHR independent. Also, single-photon emission computed tomography confirmed that radiolabeled GH rapidly reaches the ventral part of the tuberal hypothalamus. In conclusion, our study provides novel and valuable information about the pattern and mechanisms behind GH transport into the mouse brain.
Dmd
mdx mice have defective oligodendrogenesis, delayed myelin compaction and persistent hypomyelination
Authors: Arreguin Andrea J. , Shao Zijian , Colognato Holly 
Published: May 2024

ABSTRACT
Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene, resulting in the loss of dystrophin, a large cytosolic protein that links the cytoskeleton to extracellular matrix receptors in skeletal muscle. Aside from progressive muscle damage, many patients with DMD also have neurological deficits of unknown etiology. To investigate potential mechanisms for DMD neurological deficits, we assessed postnatal oligodendrogenesis and myelination in the Dmdmdx mouse model. In the ventricular-subventricular zone (V-SVZ) stem cell niche, we found that oligodendrocyte progenitor cell (OPC) production was deficient, with reduced OPC densities and proliferation, despite a normal stem cell niche organization. In the Dmdmdx corpus callosum, a large white matter tract adjacent to the V-SVZ, we also observed reduced OPC proliferation and fewer oligodendrocytes. Transmission electron microscopy further revealed significantly thinner myelin, an increased number of abnormal myelin structures and delayed myelin compaction, with hypomyelination persisting into adulthood. Our findings reveal alterations in oligodendrocyte development and myelination that support the hypothesis that changes in diffusion tensor imaging seen in patients with DMD reflect developmental changes in myelin architecture.
Dueling Contests and Platform’s Coordinating Role
Authors: Stouras Konstantinos I. , Erat Sanjiv , Lichtendahl Kenneth C. 
Published: May 2024

Crowdsourcing platforms typically take a passive approach, and they let the competing firms freely design their own contests and allow every solver to self-select and join any of the concurrently running contests. In a model of competing noise-driven contests, we show that the duopoly prize allocation has fewer (but larger) prizes compared with a monopolist contest designer. We also find that contests with firm-chosen budgets and solvers’ endogenous participation create coordination inefficiencies. Thus, platform policies that constrain the competing firms from freely choosing their budgets and offer solvers non-enforceable recommendations toward specific noise-driven contests strictly enhance total welfare. Extending our framework to include arbitrarily correlated ability-driven contests, we highlight the critical role of inter-contest dependence on the efficacy of a platform’s interventions. Specifically, platform nudges to improve solver-contest (mis)matches are welfare enhancing only when the contests are sufficiently related, and allowing solvers to self-sort is appropriate otherwise. This paper was accepted by Gabriel Weintraub, revenue management and market analytics. Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2021.03973 .
On Mignotte secret sharing schemes over Gaussian integers
Authors: Munuera Merayo Diego 
Published: May 2024

Secret Sharing Schemes (SSS) are methods for distributing a secret among a set of participants. One of the first Secret Sharing Schemes was proposed by M. Mignotte, based on the Chinese remainder theorem over the ring of integers. In this article we extend the Mignotte's scheme to the ring of Gaussian Integers and study some of its properties. While doing this we aim to solve a gap in a previous construction of such extension. In addition we show that any access structure can be made through a SSS over Z[i].
Hyperspectral in-memory computing with optical frequency combs and programmable optical memories
Authors: Latifpour Mostafa Honari , Park Byoung Jun , Yamamoto Yoshihisa , Suh Myoung-Gyun 
Published: May 2024

The rapid rise of machine learning drives demand for extensive
matrix-vector multiplication operations, thereby challenging the
capacities of traditional von Neumann computing systems. Researchers
explore alternatives, such as in-memory computing architecture, to
find energy-efficient solutions. In particular, there is renewed
interest in optical computing systems, which could potentially handle
matrix-vector multiplication in a more energy-efficient way. Despite
promising initial results, developing high-throughput optical
computing systems to rival electronic hardware remains a challenge.
Here, we propose and demonstrate a hyperspectral in-memory computing
architecture, which simultaneously utilizes space and frequency
multiplexing, using optical frequency combs and programmable optical
memories. Our carefully designed three-dimensional opto-electronic
computing system offers remarkable parallelism, programmability, and
scalability, overcoming typical limitations of optical computing. We
have experimentally demonstrated highly parallel, single-shot
multiply-accumulate operations with precision exceeding 4 bits
in both matrix-vector and matrix-matrix multiplications, suggesting
the system’s potential for a wide variety of deep learning and
optimization tasks. Our approach presents a realistic pathway to scale
beyond peta operations per second, a major stride towards
high-throughput, energy-efficient optical computing.
Study on the relationship between fixation characteristics and hit rate in psychological procedure training of free throw
Authors: Zhao Chunzhou , Liu Na , Li Sunnan 
Published: May 2024

Background
Free throw is an important means of scoring in basketball games. With the improvement of basketball competition level and the enhancement of confrontation degree, the number of free throws in the game gradually increases, so the score of free throw will have an important impact on the result of the game. The purpose of this study is to explore the relationship between visual attention characteristics and hit rate of basketball players in free throw psychological procedure training, so as to provide scientific basis for basketball teaching and training.

Methods
Forty players with similar free throw abilities were randomly assigned to the experimental group (10 males, 10 females) and control group (10 males, 10 females). The experimental group was free throw psychological procedure training, while the control group was trained with routine training, Eye movement indices (number of fixations, fixation duration, and pupil dilation) and the free throw hit rate and analyzed before and after the experiment. Group differences were examined using t-tests, while paired sample t-tests were conducted to compare pre- and post-test results within each group. The training time and training times of the two groups were the same.

Results
There were significant differences in fixation duration, number of fixations, pupil diameter and free throw hit rate between pre-test and post-test in the experimental group (P < 0.05). Post-test, there were significant differences in number of fixations, fixation duration, pupil diameter and free throw hit rate between the two groups (P < 0.05). There was a significant positive correlation between number of fixations and free throw hit rate in top (P < 0.01), and there was a significant positive correlation between fixation duration and hit rate in front (P < 0.01).

Conclusions
The psychological procedure training can improve the visual information search strategy and information processing ability of free throw, and significantly improve the free throw hit rate. There was a positive correlation between the front fixation time and the free throw hit rate, and there was a positive correlation between the top number of fixations and the free throw hit rate.
First-year outcomes of very low birth weight preterm singleton infants with hypoxemic respiratory failure treated with milrinone and inhaled nitric oxide (iNO) compared to iNO alone: A nationwide retrospective study
Authors: Chang Ya-Ting , Liu Jia-Rou , Chen Wei-Min , Tseng Chi-Nan , See Lai-Chu 
Published: May 2024

Background
Inhaled nitric oxide (iNO) has a beneficial effect on hypoxemic respiratory failure. The increased use of concurrent iNO and milrinone was observed. We aimed to report the trends of iNO use in the past 15 years in Taiwan and compare the first-year outcomes of combining iNO and milrinone to the iNO alone in very low birth weight preterm (VLBWP) infants under mechanical ventilation.

Methods
This nationwide cohort study enrolled preterm singleton infants with birth weight <1500g treated with iNO from 2004 to 2019. Infants were divided into two groups, with a combination of intravenous milrinone (Group 2, n = 166) and without milrinone (Group 1, n = 591). After propensity score matching (PSM), each group’s sample size is 124. The primary outcomes were all-cause mortality and the respiratory condition, including ventilator use and duration. The secondary outcomes were preterm morbidities within one year after birth.

Results
After PSM, more infants in Group 2 needed inotropes. The mortality rate was significantly higher in Group 2 than in Group 1 from one month after birth till 1 year of age (55.1% vs. 13.5%) with the adjusted hazard ratio of 4.25 (95%CI = 2.42–7.47, p <0.001). For infants who died before 36 weeks of postmenstrual age (PMA), Group 2 had longer hospital stays compared to Group 1. For infants who survived after 36 weeks PMA, the incidence of moderate and severe bronchopulmonary dysplasia (BPD) was significantly higher in Group 2 than in Group 1. For infants who survived until one year of age, the incidence of pneumonia was significantly higher in Group 2 (28.30%) compared to Group 1 (12.62%) (p = 0.0153).

Conclusion
Combined treatment of iNO and milrinone is increasingly applied in VLBWP infants in Taiwan. This retrospective study did not support the benefits of combining iNO and milrinone on one-year survival and BPD prevention. A future prospective study is warranted.
Depression and associated factors among older people in Vietnam: Findings from a National Aging Survey
Authors: Nguyen Nam Truong , Nguyen Trang , Bui Thu Dai , Giang Long Thanh 
Published: May 2024

Background
Depression is one of the most common mental health disorders among older people. Depressive symptoms are often overlooked and untreated in primary care settings. This study aims to assess the prevalence of depressive symptoms and associated factors among older people in Vietnam.

Method
The study analyzed data from the Vietnam National Aging Survey (VNAS) conducted in 2022 with a nationally representative sample of 3,006 older people aged 60 and over in 12 provinces. The 15-item Geriatric Depression Scale (GDS-15) was used to assess depressive symptoms. Bivariate and multiple logistic regression analyses were used to explore the association between depressive symptoms and other related factors such as sociodemographic and economic characteristics, social support, health status, Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL) limitations, chronic diseases, cigarette smoking status, alcoholic drinking, and domestic violence.

Results
The prevalence of depressive symptoms among older people was 20.2%. The associated factors that increase the odds of having depression among older people were female gender (OR = 2.21, 95% CI 1.34–3.62), living in rural areas (OR = 1.83, 95% CI 1.15–2.89), the poorest quintile (OR = 2.26, 95% CI 1.39–3.66), self-rated poor health (OR = 11.68, 95% CI 4.96–27.49), ADL limitations (OR = 2.12, 95% CI 1.51–2.99), IADL limitation (OR = 1.61 95% CI 1.16–2.25), and experiencing domestic violence in the last 12 months (OR = 6.66, 95% CI 4.00–11.05).

Conclusion
Depression symptoms were prevalent among older people in Vietnam. Depression screening for older people should be included in primary care settings for early identification and treatment of depression.
Sexual behaviour among women using intramuscular depot medroxyprogesterone acetate, a copper intrauterine device, or a levonorgestrel implant for contraception: Data from the ECHO randomized trial
Authors: Hofmeyr G. Justus , Singata-Madliki Mandisa , Batting Joanne , Steyn Petrus , Thomas Katherine K. , Issema Rodal , Beesham Ivana , Mbatsane Enough , Morrison Charles , Deese Jen , Smit Jenni , Philip Neena , Palanee-Phillips Thesla , Reddy Krishnaveni , Onono Maricianah , Mastro Timothy D. , Baeten Jared M. ,   on behalf of Evidence for Contraceptive Options and HIV Outcomes (ECHO) Trial Consortium
Published: May 2024

Background
Contraceptive use has complex effects on sexual behaviour and mood, including those related to reduced concerns about unintended pregnancy, direct hormonal effects and effects on endogenous sex hormones. We set out to obtain robust evidence on the relative effects of three contraceptive methods on sex behaviours, which is important for guiding contraceptive choice and future contraceptive developments.

Methods
This is a secondary analysis of data from the Evidence for Contraceptive Options and HIV Outcomes (ECHO) randomized trial in which 7,829 HIV-uninfected women from 12 sites in Eswatini, Kenya, South Africa and Zambia seeking contraception were randomly assigned to intramuscular depot-medroxyprogesterone acetate (DMPA-IM), the copper intrauterine device (Cu-IUD) or the levonorgestrel (LNG) implant. Data collected for 12 to 18 months using 3-monthly behavioural questionnaires that relied on recall from the preceding 3 months, were used to estimate relative risk of post-baseline sex behaviours, as well as sexual desire and menstrual bleeding between randomized groups using modified Poisson regression.

Results
We observed small but generally consistent effects wherein DMPA-IM users reported lower prevalence of specified high risk sexual behaviours than implant users than Cu-IUD users (the ‘>‘ and ‘<‘ symbols indicate statistically significant differences): multiple sex partners 3.6% < 4.8% < 6.2% respectively; new sex partner 3.0% < 4.0% <5.3%; coital acts 16.45, 16.65, 17.12 (DMPA-IM < Cu-IUD); unprotected sex 65% < 68%, 70%; unprotected sex past 7 days 33% <36%, 37%; sex during vaginal bleeding 7.1%, 7.1% < 8.9%; no sex acts 4.1%, 3.8%, 3.4% (DMPA-IM > Cu-IUD); partner has sex with others 10% < 11%, 11%. The one exception was having any sex partner 96.5%, 96.9% < 97.4% (DMPA-IM < Cu-IUD). Decrease in sexual desire was reported by 1.6% > 1.1% >0.5%; amenorrhoea by 49% > 41% >12% and regular menstrual pattern by 26% <35% < 87% respectively.

Conclusions
These findings suggest that women assigned to DMPA-IM may have a modest decrease in libido and sexual activity relative to the implant, and the implant relative to the Cu-IUD. We found more menstrual disturbance with DMPA-IM than with the implant (and as expected, both more than the Cu-IUD). These findings are important for informing the contraceptive choices of women and policymakers and highlight the need for robust comparison of the effects of other contraceptive methods as well.