bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Family of Fast and Memory Efficient Lock- and Wait-Free Reclamation
Authors: Nikolaev Ruslan , Ravindran Binoy 
Published: June 2024

Historically, memory management based on lock-free reference counting was very inefficient, especially for read-dominated workloads. Thus, approaches such as epoch-based reclamation (EBR), hazard pointers (HP), or a combination thereof have received significant attention. EBR exhibits excellent performance but is blocking due to potentially unbounded memory usage. In contrast, HP are non-blocking and achieve good memory efficiency but are much slower. Moreover, HP are only lock-free in the general case. Recently, several new memory reclamation approaches such as WFE and Hyaline have been proposed. WFE achieves wait-freedom, but is less memory efficient and performs suboptimally in oversubscribed scenarios; Hyaline achieves higher performance and memory efficiency, but lacks wait-freedom.We present a family of non-blocking memory reclamation schemes, called Crystalline, that simultaneously addresses the challenges of high performance, high memory efficiency, and wait-freedom. Crystalline can guarantee complete wait-freedom even when threads are dynamically recycled, asynchronously reclaims memory in the sense that any thread can reclaim memory retired by any other thread, and ensures (an almost) balanced reclamation workload across all threads. The latter two properties result in Crystalline's high performance and memory efficiency. Simultaneously ensuring all three properties requires overcoming unique challenges. Crystalline supports ubiquitous x86-64 and ARM64 architectures, while achieving superior throughput than prior fast schemes such as EBR as the number of threads grows.We also accentuate that many recent approaches, unlike HP, lack strict non-blocking guarantees when used with multiple data structures. By providing full wait-freedom, Crystalline addresses this problem as well.
ZPredict: ML-Based IPID Side-channel Measurements
Authors: Schulmann Haya , Zhao Shujie 
Published: June 2024

Network reconnaissance and measurements play a central role in improving Internet security and are important for understanding the current deployments and trends. Such measurements often require coordination with the measured target. This limits the scalability and the coverage of the existing proposals. IP Identification (IPID) provides a side channel for remote measurements without requiring the targets to install agents or visit the measurement infrastructure. However, current IPID-based techniques have technical limitations due to their reliance on the idealistic assumption of stable IPID changes or prior knowledge, making them challenging to adopt for practical measurements.
In this work, we aim to tackle the limitations of existing techniques by introducing a novel approach: predictive analysis of IPID counter behavior. This involves utilizing a machine learning (ML) model to understand the historical patterns of IPID counter changes and predict future IPID values. To validate our approach, we implement six ML models and evaluate them on realistic IPID data collected from 4,698 Internet sources. Our evaluations demonstrate that among the six models, the Gaussian Process (GP) model has superior accuracy in tracking and predicting IPID values.
Using the GP-based predictive analysis, we implement a tool, called ZPredict, to infer various favorable information about target networks or servers. Our evaluation on a large dataset of public servers demonstrates its effectiveness in idle port scanning, measuring Russian censorship, and inferring Source Address Validation.
Our study methodology is ethical and was developed to mitigate any potential harm, taking into account the concerns associated with measurements.
Lanthanum Substituted Mg-Zn Ferrite Nanostructures: A Comprehensive Study of Cation Distribution, Structural, Morphological, Optical, Magnetic, Dielectric, and Electromagnetic Traits
Authors: Jasrotia Rohit , Sharma Anand , Ahmed Jahangeer , Verma Ritesh , Alshehri Saad M. , Lakshmaiya Natrayan , Sillanpää Mika , Kumar Rajinder , Khanna Virat 
Published: June 2024

The sol-gel auto-combustion (SC) procedure was utilised to fabricate lanthanum-doped Mg-Zn nanostructures with the chemical composition, Mg0.6Zn0.4LaxFe2-xO4, (x = 0, 0.05, 0.10). X-ray diffraction showed nanocrystalline and single-phase of Mg-Zn nanostructures. The morphological traits showed formation of irregular and aggregated grains. Fourier transform infrared spectroscopy detected the formation of two characteristic band positions that fall within the range of 400 to 600 cm−1 and may occur because of stretching vibration within metal-oxygen (M-O) cations located at interstitial positions. From the M-H loops, the excellent values of magnetic factors, such as the saturation magnetization (Ms), rentivity (Mr), and coercivity (Hc) ranging from 35.30 to 44.79 emu g−1, 1.40 to 3.75 emu g−1, and 11.56 to 41.42 Oe were obtained. The loss tangent (tan δ) was observed to be miniscule for all of the samples due to which they can be useful for electronic applications. However, the initial values of the real permeability (

μ

′

) was high and it decreases until 4 GHz, after which it acquires a constant value for rest of frequency range. However, observed low values of the magnetic loss tangent (tan δ

μ
) were due to the large grain size and the high densification of the samples.
CD28 Costimulation Augments CAR Signaling in NK Cells via the LCK/CD3ζ/ZAP70 Signaling Axis
Authors: Acharya Sunil , Basar Rafet , Daher May , Rafei Hind , Li Ping , Uprety Nadima , Ensley Emily , Shanley Mayra , Kumar Bijender , Banerjee Pinaki P. , Melo Garcia Luciana , Lin Paul , Mohanty Vakul , Kim Kun H. , Jiang Xianli , Pan Yuchen , Li Ye , Liu Bin , Nunez Cortes Ana K. , Zhang Chenyu , Fathi Mohsen , Rezvan Ali , Montalvo Melisa J. , Cha Sophia L. , Reyes-Silva Francia , Shrestha Rejeena , Guo Xingliang , Kundu Kiran , Biederstädt Alexander , Muniz-Feliciano Luis , Deyter Gary M. , Kaplan Mecit , Jiang Xin R. , Liu Enli , Jain Antrix , Roszik Janos , Fowlkes Natalie W. , Solis Soto Luisa M. , Raso Maria G. , Khoury Joseph D. , Lin Pei , Vega Francisco , Varadarajan Navin , Chen Ken , Marin David , Shpall Elizabeth J. , Rezvani Katayoun 
Published: June 2024

Abstract
Multiple factors in the design of a chimeric antigen receptor (CAR) influence CAR T-cell activity, with costimulatory signals being a key component. Yet, the impact of costimulatory domains on the downstream signaling and subsequent functionality of CAR-engineered natural killer (NK) cells remains largely unexplored. Here, we evaluated the impact of various costimulatory domains on CAR-NK cell activity, using a CD70-targeting CAR. We found that CD28, a costimulatory molecule not inherently present in mature NK cells, significantly enhanced the antitumor efficacy and long-term cytotoxicity of CAR-NK cells both in vitro and in multiple xenograft models of hematologic and solid tumors. Mechanistically, we showed that CD28 linked to CD3ζ creates a platform that recruits critical kinases, such as lymphocyte-specific protein tyrosine kinase (LCK) and zeta-chain-associated protein kinase 70 (ZAP70), initiating a signaling cascade that enhances CAR-NK cell function. Our study provides insights into how CD28 costimulation enhances CAR-NK cell function and supports its incorporation in NK-based CARs for cancer immunotherapy.
Significance: We demonstrated that incorporation of the T-cell–centric costimulatory molecule CD28, which is normally absent in mature natural killer (NK) cells, into the chimeric antigen receptor (CAR) construct recruits key kinases including lymphocyte-specific protein tyrosine kinase and zeta-chain-associated protein kinase 70 and results in enhanced CAR-NK cell persistence and sustained antitumor cytotoxicity.
Paradoxical Change in Subchondral Bone Density in the Medial Compartment of the Proximal Tibial Articular Surface After High Tibial Osteotomy: A Detailed Subchondral Bone Density Analysis
Authors: Fujie Yuki , Iwasaki Koji , Hamasaki Masanari , Suzuki Yuki , Matsuoka Masatake , Onodera Tomohiro , Kondo Eiji , Iwasaki Norimasa 
Published: June 2024

Background: High tibial osteotomy (HTO) aims to realign the varus knee to alleviate stress in the medial compartment. However, detailed information on the impact of HTO on stress distribution across the tibiofemoral joint surface still needs to be completely elucidated. Purpose/Hypothesis: The present study aimed to analyze the subchondral bone density distribution to validate the alignment threshold causing paradoxical changes. We hypothesized that there would be a paradoxical stress change in the medial compartment beyond a specific threshold for lower limb realignment after HTO. Study Design: Case series; Level of evidence, 4. Methods: A retrospective clinical study of 32 knees from 30 patients who underwent medial opening-wedge HTO between 2015 and 2019 was conducted at Hokkaido University Hospital. The subchondral bone density across the tibiofemoral joint was analyzed using computed tomography–osteoabsorptiometry before and after HTO. The high-density area (HDA) within the medial and lateral compartments and their subregions, which were quartered in the coronal plane, was specifically examined. Results: The hip-knee-ankle angle, medial proximal tibial angle (MPTA), joint line obliquity (JLO), and joint line convergence angle significantly changed after HTO ( P < .01). The HDA of the medial compartment to the total HDA ratio decreased from 83% to 77%. Paradoxically, the HDA in the most central subregion of the medial compartment increased from 24% to 30%. There were significant differences between MPTA and JLO in patients with and without paradoxical changes in the HDA. MPTA and JLO cutoff values causing paradoxical changes in the HDA were 94° and 4°, respectively. Conclusion: There was a paradoxical stress increase in the M4 region at the medial compartment associated with the MPTA and JLO beyond specific thresholds. Therefore, surgical planning should be cautiously performed to prevent overcorrection, which can lead to adverse stress distribution changes.
Understanding Reasons for Cancer Disparities in Italy: A Qualitative Study of Barriers and Needs of Cancer Patients and Healthcare Providers
Authors: Ferraris Giulia , Coppini Veronica , Ferrari Maria Vittoria , Monzani Dario , Grasso Roberto , Pravettoni Gabriella 
Published: June 2024

Background The second leading cause of death in Italy is cancer. Substantial disparities persist in the level of care and outcomes for cancer patients across various communities, hospitals, and regions in Italy. While substantial progress has been made in medical research and treatment options, these advancements tend to disproportionately benefit the wealthier, better-educated, and more privileged areas and portions of the population. Therefore, the primary aim of the current study is to explore possible reasons for inequalities in access to and utilisation of care from the perspective of cancer patients, who are recipients of these treatments, and healthcare providers, who are responsible for their administration. Methods After being recruited through social media platforms, patients’ organisations, and hospital websites, cancer patients (n = 22) and healthcare providers (n = 16) from various Italian regions participated in online focus group discussions on disparities in access to and provision of care. Video and audio recordings of the interviews were analysed using Thematic analysis. Results Among cancer patients, 7 themes were identified, while 6 themes emerged from the healthcare providers highlighting encountered barriers and unmet needs in cancer care. Most of these emerging themes are common to both groups, such as geographical disparities, information deficiencies, and the importance of psycho-oncological support. However, several themes are specific to each group, for instance, cancer patients highlight the financial burden and the poor interactions with healthcare providers, while healthcare providers emphasise the necessity of establishing a stronger specialists’ network and integrating clinical practice and research. Conclusion Current findings reveal persistent challenges in cancer care, including long waiting lists and regional disparities, highlighting the need for inclusive healthcare strategies. The value of psycho-oncological support is underscored, as well as the potential of the Internet’s use for informational needs, emphasising the imperative for improved awareness and communication to overcome disparities in cancer care.
Impairment Assessment in Adult ADHD and Related Disorders: Current Opinions From Clinic and Research
Authors: Fuermaier Anselm B. M. , Gontijo-Santos Lima Caroline , Tucha Oliver 
Published: June 2024

Objectives: Assessing functional impairment is one of the essential components in the clinical evaluation of ADHD in adulthood, serving both diagnostic and outcome evaluation purposes. However, clinicians and researchers may face challenges in selecting suitable instruments due to variations in accessibility and quality of instruments. Methods: We conducted an online survey involving an international group of 92 respondents engaged in clinical practice and/or research on ADHD. The survey aimed to evaluate current practices in assessing impairment in adult ADHD and related disorders, while also identifying areas requiring adaptation or potential new developments. Results: Our findings revealed that clinicians and researchers utilize a diverse range of instruments for assessing impairment in adults with ADHD, including some that may lack adequate properties for this purpose. Notably, dissatisfaction with current practice standards was expressed, underscoring the need for novel assessment approaches and improved psychometric properties. Conclusion: It is evident that research endeavors are warranted to either refine existing measures or devise new ones for assessing functional impairment in adult ADHD. Emphasis should be placed on disseminating instruments that enhance accessibility in both research and clinical settings, and facilitate streamlined administration and interpretation.
Mass Spectrometry Proteomics Characterization of Plasma Biomarkers for Colorectal Cancer Associated With Inflammation
Authors: Urbiola-Salvador Víctor , Jabłońska Agnieszka , Miroszewska Dominika , Kamysz Weronika , Duzowska Katarzyna , Drężek-Chyła Kinga , Baber Ronny , Thieme René , Gockel Ines , Zdrenka Marek , Śrutek Ewa , Szylberg Łukasz , Jankowski Michał , Bała Dariusz , Zegarski Wojciech , Nowikiewicz Tomasz , Makarewicz Wojciech , Adamczyk Agnieszka , Ambicka Aleksandra , Przewoźnik Marcin , Harazin-Lechowska Agnieszka , Ryś Janusz , Macur Katarzyna , Czaplewska Paulina , Filipowicz Natalia , Piotrowski Arkadiusz , Dumanski Jan P , Chen Zhi 
Published: June 2024

Background: Colorectal cancer (CRC) prognosis is determined by the disease stage with low survival rates for advanced stages. Current CRC screening programs are mainly using colonoscopy, limited by its invasiveness and high cost. Therefore, non-invasive, cost-effective, and accurate alternatives are urgently needed. Objective and design: This retrospective multi-center plasma proteomics study was performed to identify potential blood-based biomarkers in 36 CRC patients and 26 healthy volunteers by high-resolution mass spectrometry proteomics followed by the validation in an independent CRC cohort (60 CRC patients and 44 healthy subjects) of identified selected biomarkers. Results: Among the 322 identified plasma proteins, 37 were changed between CRC patients and healthy volunteers and were associated with the complement cascade, cholesterol metabolism, and SERPIN family members. Increased levels in CRC patients of the complement proteins C1QB, C4B, and C5 as well as pro-inflammatory proteins, lipopolysaccharide-binding protein (LBP) and serum amyloid A4, constitutive (SAA4) were revealed for first time. Importantly, increased level of C5 was verified in an independent validation CRC cohort. Increased C4B and C8A levels were correlated with cancer-associated inflammation and CRC progression, while cancer-associated inflammation was linked to the acute-phase reactant leucine-rich alpha-2-glycoprotein 1 (LRG1) and ceruloplasmin. Moreover, a 4-protein signature including C4B, C8A, apolipoprotein C2 (APO) C2, and immunoglobulin heavy constant gamma 2 was changed between early and late CRC stages. Conclusion: Our results suggest that C5 could be a potential biomarker for CRC diagnosis. Further validation studies will aid the application of these new potential biomarkers to improve CRC diagnosis and patient care.
Migraine headache in patients with spontaneous coronary artery dissection: A report of the iSCAD Registry
Authors: Wells Bryan J , Wood Malissa J , O’Duffy Anne E , Sumner Jennifer A , Chi Gerald , Grodzinsky Anna , Gornik Heather L , Kadian-Dodov Daniella , Taylor Angela , Hess Connie N , Sanghavi Monika , Henkin Stanislav , Wells Gretchen , Tam Lori , Orford James , Lindley Kathryn , Kumbhani Dharam J , Vitarello Clara , Alkhalfan Fahad , Gibson C Michael , Leon Katherine K , Naderi Sahar , Kim Esther SH 
Published: June 2024

Introduction: Spontaneous coronary artery dissection (SCAD) is a nonatherosclerotic cause of myocardial infarction. Migraine headache has been reported to be common among patients with SCAD, but the degree of migraine-related disability has not been quantified. Methods: Clinical data and headache variables were obtained from the baseline assessment of the prospective, multicenter iSCAD Registry. Migraine-related disability was quantified using the self-reported Migraine Disability Assessment (MIDAS). Demographic, clinical, psychosocial, and medical characteristics from data entry forms were compared between patients with and without migraine. Results: Of the 773 patients with available data, 46% reported previous or current migraines. Those with migraines were more likely to be women (96.9% vs 90.3%, p = 0.0003). The presence of underlying carotid fibromuscular dysplasia was associated with migraine (35% vs 27%, p = 0.0175). There was not a significant association with carotid artery dissection and migraine. Current migraine frequency was less than monthly (58%), monthly (24%), weekly (16%), and daily (3%). Triptan use was reported in 32.5% of patients, and 17.5% used daily migraine prophylactic medications. Using the MIDAS to quantify disability related to migraine, 60.2% reported little or no disability, 14.4% mild, 12.7% moderate, and 12.7% severe. The mean MIDAS score was 9.9 (mild to moderate disability). Patients with SCAD had higher rates of depression and anxiety (28.2% vs 17.7% [ p = 0.0004] and 35.3% vs 26.7% [ p = 0.0099], respectively). Conclusions: Migraines are common, frequent, and a source of disability in patients with SCAD. The association between female sex, anxiety, and depression may provide some insight for potential treatment modalities.
The uncompromising way: Several lessons from homeless journalists
Authors: Dvořák Vojtěch 
Published: June 2024

The radical role of media is about challenging norms, advocating for justice, and amplifying marginalized voices. One such group is the unhoused population. The media owe them a debt by perpetuating disempowering narratives and stereotypes about homelessness. This article examines the practices of unhoused individuals engaged in participatory community journalism and their implications for professional journalists. Based on over 3 years of participatory action and critical ethnography research in the Czech Republic and Colorado, it presents several lessons for journalists to learn from homeless journalists. The findings show that involving unhoused people in journalism can equalize inevitably unequal power relations and promote truth-seeking. The article highlights that the highest forms of media participation may not always be the most empowering, and instead, promoting dialogue through partnership is crucial. Ultimately, it calls on professional journalists to embrace the new radical role by critically examining their power and being open to sharing or giving it up for the benefit of marginalized voices.
Australian perspectives on environmental practice: A national survey with human service professionals
Authors: Boetto Heather , Bowles Wendy , Ramsay Sylvia , Shephard Monique , Cordoba Pushkar Sebastian 
Published: June 2024

Summary This article reports on research exploring the perspectives of Australian social work and human service professionals about environmental practice. An online survey consisting of quantitative and qualitative questions was conducted, recruiting 303 participants from the human services sector. Quantitative data were analyzed descriptively using SPSS and qualitative data analyzed thematically using NVivo. Findings Overall, results indicated that participants strongly supported an environmental focus in human services at personal and professional levels of practice. However, while participants expressed values supporting environmental practice, its implementation was less frequently reported. The adverse impacts of climate change were reported as strongly impacting the well-being of service users, and a general lack of support from employing organizations to facilitate environmental practice was evident. Despite a strong belief in the value of Australian First Nations knowledges, limited engagement with Australian First Nations peoples was practiced. Applications Implications suggest the need to examine the practical realities of environmental practice including the disconnect between values and action. Given that participants reported adverse impacts of climate change on people and communities, but faced significant challenges implementing environmental action, the need to disrupt barriers caused by the dominant neoliberal discourse is critical. Likewise, disrupting the prevailing colonialist discourse by working alongside First Nations peoples to decolonize society and the profession is essential for enacting principles of environmental sustainability.
Patient safety of adjunct pre-operative intravenous S-ketamine for pain relief in third molar surgery – a randomised, placebo-controlled, double-blind trial
Authors: Eriksson Lars B , Gordh Torsten , Karlsten Rolf , Thor Andreas , Tegelberg Åke 
Published: June 2024

Purpose To study patient safety in third molar surgery, where two different doses of S-ketamine were administered for pain relief and compared to a placebo (saline). The primary focus was capillary oxygen saturation of the blood (SpO2) and secondarily, alterations in respiratory rate, blood pressure, pulse or adverse events. Methods One hundred and sixty-eight subjects were included in a randomised, placebo-controlled, double-blind trial. The two subanaesthetic study drugs were low-dose S-ketamine (0.125 mg/kg) and high-dose S-ketamine (0.25 mg/kg). Every patient was sedated with midazolam prior to infusion of the investigational drug. The teeth were surgically removed according to a routine clinical procedure, under local anaesthesia. Results Primary end-point for the safety aspects was capillary oxygen saturation (SpO2) after administration of the investigational drug was finished. A significant difference was found between the placebo and the high-dose group at that point ( p = .021), with a decrease of saturation in the high-dose group. The lowest saturation and the number of registrations of SpO2 <90% did not show any difference between groups. Oxygen supplementation was given in circa 40% of the cases with no differences between the intervention groups. No other significant differences between groups regarding saturation or respiratory rate were noted. Conclusion In this study, it was safe to use adjunct preoperative single-dose intravenous S-ketamine 0.25 mg/kg body weight for pain relief, in midazolam-sedated patients receiving third molar surgery. There were no serious adverse events or symptoms of overdose nor any clinically relevant effects on circulatory or respiratory parameters.