bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between Insulin-Like Growth Factor Binding Protein-7 and Heart Failure
Authors: Ghasempour Parisa , Khanmohammadi Shaghayegh , Rezaei Nima 
Published: February 2025

Abstract:
Heart failure (HF), a widespread public health issue, affects about 26 million
people all around the world, and its incidence and prevalence are still growing. Measuring
serum biomarkers is beneficial in diagnosing HF and evaluating its prognosis. During
the previous decade, various investigations have focused on identifying new HF biological
markers that would have additional and/or superior prognostic, diagnostic, or
classification value. While heart-specific biological markers, such as atrial natriuretic
peptide (ANP) and brain natriuretic peptide (BNP), are commonly applied in clinical
practice, there is still an unmet need for new markers in HF management. Insulin-like
growth factor-binding protein-7 (IGFBP7), a cellular senescence marker, has been considered
as a candidate biomarker in HF. This study aims to comprehensively reveal the
underlying mechanism connecting IGFBP-7 to HF and review studies evaluating the
prognostic or diagnostic performance of IGFBP-7 in combination with or in contrast
with other potential HF biological markers. Increased IGFBP7 levels are associated with
a set of functional and structural heart abnormalities such as diastolic dysfunction. Increased
IGFBP7 concentrations seem to be an indicator of cardiac overload or injury
and are related to HF major risk factors, including atherosclerosis, diabetes, and renal
function. IGFBP7 is predictive of short and long-term outcomes in the HF population
and can independently predict the rate of hospitalization and HF-related mortality.
Engineered Anti-Microbial Peptides Inhibit Cell Viability, Promote Apoptosis, and Induce Cell Cycle Arrest in SW620 Human Colon Adenocarcinoma Cells
Authors: Hashem Sheema , Bhat Ajaz A. , Nisar Sabah , Uddin Shahab , Merhi Maysaloun , Mateo Jericha M. , Prabhu Kirti S. , Soubra Lama , dos Santos Silva Carlos André , Benko-Iseppon Ana Maria , Vilela Lívia Maria Batista , de Lima Marx Oliveira , da Silva Juliana Georgia , Haris Mohammad , Suleman Muhammad , Crovella Sergio , Abou Saleh Haissam 
Published: February 2025

Background:
Colorectal cancer (CRC) is one of the most common malignancies worldwide,
and despite advances in treatment, there remains a critical need for novel therapeutic approaches.
Recently, anti-microbial peptides (AMPs) have gained attention for their potential use
in cancer therapy due to their selective cytotoxicity towards cancer cells.

Objective:
This study aims to evaluate the anti-cancer potential of two computationally engineered
anti-microbial peptides (EAMPs) in SW620, SW480, and HCT116 colon cancer cells and
the normal colon epithelial cell line CCD 841, focusing on their effects on cell proliferation, apoptosis,
and DNA damage.

Method:
Cell proliferation and survival were measured using the CellTiter-Glo Luminescence and
clonogenic assays. DNA damage was assessed through the Terminal deoxynucleotidyl transferase
dUTP nick end labeling (TUNEL) assay. Flow cytometry was used to examine cell apoptosis, cell
cycle distribution, and mitochondrial membrane potential in SW620 cells.

Results:
EAMPs inhibited CRC cell proliferation in a dose-dependent manner, with minimal toxicity
observed in normal colon epithelial cells. In SW620 cells, EAMPs induced DNA damage, resulting
in cell cycle arrest at the S/G2 phase, apoptosis, and a reduction in mitochondrial membrane
potential. The proliferation results were confirmed in SW480 and HCT116 CRC cell lines.

Conclusion:
Our findings revealed that EAMPs exhibited significant anti-cancer activity against
CRC cells in vitro while sparing normal epithelial cells. These results suggest that EAMPs may offer
a potential therapeutic approach for colorectal cancer and warrant further investigation.
Predictive Accuracy of 24-Hour Ambulatory Blood Pressure Monitoring Versus Clinic Blood Pressure for Cardiovascular and All-Cause Mortality: A Systematic Review and Meta-Analysis
Authors: Soleimani Hamidreza , Mohammadi Negin Sadat Hosseini , Montazeri Namin Sara , Nasrollahizadeh Amir , Azardar Tara , Najafi Kimia , Cilingiroglu Mehmet , Syed Mushabbar , Askari Mani K. , Gupta Rahul , Aronow Wilbert S. , Hosseini Kaveh 
Published: February 2025

Background:
According to current clinical practice guidelines, ambulatory blood pres-sure measurement (ABPM) is recommended to confirm diagnoses of hypertension. It remains un-clear as to which method is superior in predicting mortality outcomes.

Methods:
Prospective observational studies, comparing ABPM with clinical blood pressure meas-urements (CBPM), were included with outcomes of the study being all-cause and cardiovascular mortality.

Results:
Nine studies with a total of 23,140 participants were included. Each 10-mmHg increase in 24-hour mean systolic blood pressure (SBP) was linked to a higher risk of all-cause mortality (HR: 1.13, 95% CI: 1.09–1.18), while clinic blood pressure measurement (CBPM) was not a sig-nificant predictor (HR: 1.02, 95% CI: 0.90–1.13). Nighttime SBP increases of 10 mmHg were associated with a higher all-cause mortality risk than daytime SBP (HR: 1.16, 95% CI: 1.11–1.21 versus HR: 1.08, 95% CI: 1.05–1.12). For cardiovascular mortality, a 10 mmHg increase in SBP yielded an HR of 1.21 (95% CI: 1.16–1.27) for 24-hour ABPM compared to 1.08 (95% CI: 1.04–1.11) for CBPM. Similarly, for a 5 mmHg increase in diastolic blood pressure (DBP), the HR was 1.14 (95% CI: 1.07–1.20) for 24-hour ABPM versus 1.04 (95% CI: 1.01–1.07) for clinical DBP, highlighting 24-hour monitoring as a stronger predictor for cardiovascular mortality.

Conclusion:
The findings of this study support the superiority of ABPM measurements in predict-ing both all-cause and cardiovascular mortality.
Digital Economy and Carbon Neutral Technological Innovation
Authors: Wang Ruiqi 
Published: February 2025

To achieve sustainable development, improve global competitiveness, promote ecological civilization building, and ease economic transition and upgrading, carbon neutral technical innovation is essential. This paper examines the effect with panel data from 270 Chinese from 2006 to 2022, as well as multidimensional heterogeneity analysis. The conclusions are as follows. (1) Digital economy can promote carbon neutral technological innovation. (2) The mechanism test demonstrates how scientific and technological production and regional innovation potential might contribute to carbon neutral technology innovation in the digital economy. (3) Heterogeneity analysis shows that based on the three-dimensional city attributes of “location-feature-scale”, the research results show significant differences across different cities. The research conclusions provide a certain reference value for further strengthening and promoting carbon neutral technology innovation.
Latin-Russian-Kalmyk Dictionary by Adrian Sokolov (1769–1771): General Description and Some Remarks on Its Grapho-phonetic Features
Authors:   Kalmyk Scientific Center of the RAS, Mirzaeva Saglara V. 
Published: February 2025

Introduction. Lexicographic sources are of special value in the studies on the history of any language. As for Kalmyk language, the earliest sources of such kind dating back to the second half of the 18th century are an anonymous Russian-Kalmyk dictionary published by Kalmyk researchers in 2014 and Latin-Russian-Kalmyk dictionary by Adrian Sokolov (1769–1771), which has yet to be introduced into scientific circulation. This paper aims to provide a general description of A. Sokolov's dictionary and to analyze some grapho-phonetic features of the Kalmyk language of the second half of the 18th century. The study is based on “Kalmükisch Vocabularium von Studenten Adrian Sokolov in den Jahren 1769, 1770 und 1771” stored in collections of National Library of Russia (St. Petersburg). The dictionary consists of 76 pages and includes 1,785 Kalmyk words. We compiled the Russian-Kalmyk part of the dictionary and added modern literary Kalmyk forms, after that the dictionary materials were uploaded to Lingvodoc platform to provide comparative analysis with Proto-Mongolic and contemporary literary Kalmyk forms. Results. The particular value of this dictionary is that it contains an author's Cyrillic transcription of Kalmyk words, made by an outside observer unfamiliar with the rules of the literary (written) language, and therefore more accurately (in our opinion) reflecting the characteristics of Kalmyk oral speech of this period. The correspondences established in the dictionary, such as e — lit. Kalm. ө (Proto-Mongolic *e), o — lit. Kalm. ɵ, ai / oi — lit. Kalm. a, i — lit. Kalm. ү, b — lit. Kalm. в, coincide with Proto-Mongolic reflexes and can be characterized as archaic features of the Kalmyk language of the second half of the 18th century. They are also found in the Kalmyk wordlists made by German scholars of the same period, such as G. F. Müller (1760–1762), P. S. Pallas (1771, 1776–1789), B. Bergman (1804–1805), and J. G. Klaproth (1831). This allows us to conclude that these linguistic features were typical for the Kalmyk language of this period as a whole, and not just for separate dialects. The innovative correspondences such as e — lit. Kalm. ɵ (Proto-Mongolic *ö), o — lit. Kalm. у, and ts — lit. Kalm. ч are also found in the abovementioned wordlists, which may indicate the fact that they were supra-dialectal. The correspondences io — lit. Kalm. ү, u — lit. Kalm. ө, u — lit. Kalm. ү are only found in B. Bergman's materials, who recorded, supposedly, Derbet dialect of the Kalmyk language. Thus, we can suggest that the dictionary by A. Sokolov also reflects the dialectal features of Derbet dialect of the Kalmyk language of the second half of 18th century.
PENGARUH FERMENTASI FESES AYAM LAYER SEBAGAI MEDIA TUMBUH TERHADAP KANDUNGAN LEMAK DAN GROSS ENERGY (GE) PADA MAGGOT
Authors: ROSANTI RITA 
Published: February 2025

Penelitian ini bertujuan untuk mengetahui pengaruh fermentasi feses ayam layer sebagai media tumbuh terhadap kandungan lemak kasar dan gross energy maggot. Penelitian ini dilaksanakan di peternakan ayam layer PT. Talaga Unggas Bahagia Kecamatan Sukahaji, Kabupaten Majalengka, Jawa Barat pada bulan Maret-Mei 2023. Objek yang digunakan dalam penelitian ini adalah maggot yang beru 21 hari. Penelitian ini dilakukan dengan metode eksperimental dengan metode Rancangan Acak Lengkap (RAL), yang terdiri atas 3 perlakuan yaitu P1 (Fermentasi Feses Ayam Layer), P2 (Fermentasi Feses Ayam Layer + 2% ekoenzim), dan P3 (Fermentasi Feses Ayam Layer + 0,25% Stardec) dan diulang sebanyak 6 kali. Hasil penelitian menunjukkan bahwa fermentasi feses ayam layer dengan Stardec sangat berbeda nyata (P<0,01) terhadap kandungan lemak kasar dan gross energy maggot. Fermentasi feses layer yang menggunakan Stardec menghasilkan nilai lemak kasar (10,81%) dan gross energy (4.456,50 kkal/kg) yang terbaik untuk dijadikan sebagai pakan ternak.
Optimizing Loan Approval Processes with Support Vector Machines (SVM)
Authors: Angraini Novita , Rosalina Kelly , Kosasih Andini 
Published: February 2025

Loan approval is a critical process in banking, requiring accurate assessment of borrower risk to minimize defaults while maintaining customer satisfaction. This study explores the optimization of loan approval processes using Support Vector Machines (SVM), a robust machine learning method known for its effectiveness in classification tasks. We utilized a dataset comprising historical loan applications, incorporating features such as credit score, income level, debt-to-income ratio, and employment history. The SVM model was trained and evaluated using cross-validation techniques to ensure generalizability. Our results demonstrate that SVM outperforms traditional statistical methods in predicting loan approval decisions, achieving higher accuracy and a significant reduction in false positives. Furthermore, feature importance analysis revealed that credit score and debt-to-income ratio are the most influential factors in the model's decision-making process. By integrating the optimized SVM model into existing banking workflows, institutions can streamline their approval processes, reduce operational costs, and improve customer experience. This study highlights the potential of SVM in modernizing decision-making frameworks in the banking sector, paving the way for further adoption of advanced machine learning techniques in financial services.
The Problem of Philosophical Foundations of Human Dignity in Law
Authors: Rosenkranzová Olga 
Published: February 2025

Summary
May human dignity be the basis of human rights? May human rights still be derived from human dignity if we also accept a non-hierarchical organization of law? Or are human rights and human dignity more of a moral character which needs to be constantly justified? Is it not a paradox that human dignity, which is the basis of human rights, may be associated not only with rights, but also simultaneously with obligations? We derive human rights from human dignity as the highest value. May we admit other values besides dignity and how shall we deal with responsibilities? Although the Kantian concept of dignity as a philosophical historical concept is inconsistent with the modern understanding of dignity in law in many respects, we would still find in Immanuel Kant a concept of dignity consisting more in duties than in rights, due to the moral nature of dignity and law according to him.
Some Remarks on Dignity in the Jurisprudence of the Polish Constitutional Tribunal
Authors: Syryt Aleksandra 
Published: February 2025

Summary
Human dignity is a legal category that emerged in the 20th century due to the experiences of World War II and totalitarianism. Today, it is a recurring theme in international and national laws, including constitutions. In Poland, public authorities are mandated to uphold and safeguard dignity. The Constitution of the Republic of Poland elevates the concept of dignity to a legal norm that guides the actions of public authorities. The Constitutional Tribunal has made several statements about dignity, which provide a comprehensive understanding of the subject from various perspectives. This article explores the jurisprudential perspective that has shaped the constitutional approach to dignity in Poland, focusing on the Polish jurisprudence of the Constitutional Tribunal, which is influenced by comparative law.
Design and verification of down asynchronous counter using toggle flip-flop in QCA
Authors: Shaw Rohit Kumar , Khan Angshuman 
Published: February 2025

Abstract
This study presents an innovative single-layered toggle flip-flop with highly polarized output designed specifically for Quantum-dot Cellular Automata (QCA), a cutting-edge nanocomputing approach. Building on the capabilities of this advanced flip-flop, a two-bit asynchronous down (ripple) counter was developed using QCADesigner 2.0.3, all within the QCA framework. The counter exhibits exceptional scalability and reliability, addressing key challenges in QCA circuit design. Energy efficiency and cost-effectiveness are standout features of the design, with a 53% improvement in energy efficiency and a 38% reduction in QCA-specific cost, as verified by QCADesigner-E 2.2 simulations. Furthermore, the physical stability of the proposed circuit was thoroughly examined through kink energy calculations, highlighting its robustness. These optimizations were achieved by avoiding complex crossovers and leveraging the benefits of the enhanced flip-flop architecture. The results underscore the significant potential of QCA in improving digital circuit performance, paving the way for more efficient, scalable, and cost-effective nanoelectronic designs and pushing the boundaries of next-generation nanocomputing solutions.
March ‘68 and Its Aftermath: in Polish Popular Music
Authors: Gradowski Mariusz 
Published: February 2025

Abstract
The events of March 1968 in Poland can be viewed as four overlapping threads (i.e. lines of development): 1) factionalism in the ruling party, 2) the intellectuals’ protest against the government’s cultural policies, 3) a student revolt, 4) an anti-Semitic campaign, all in the wake of international events in 1967–68. These developments intertwined in a series of events, the most notable of which were the pacification of students by the milicja (state police) on 8 March and the forced emigration of thousands of Polish Jews as a result of the anti-Semitic political campaign. In this paper, the author examines the period’s popular music which reflects the events of March ‘68. The limited number of songs is a consequence of the prevailing conditions in Polish popular music at that time. The rock genre remained the domain of teenagers, recordings were subject to restrictions, and the recording process remained under the control of the censorship. As a result, popular songs (in the broadest sense of the term) that deal with the theme of March ‘68 are part of the independent legacy of the so-called ‘student culture’, preserved outside the mainstream, mainly in oral tradition. Maciej Zembaty’s ‘Pan Prokurator ma rację’ [‘Mr Prosecutor is Right’] is analyzed here as a case study of a March ‘68 protest song. It has been paired with Andrzej Zieliński and Agnieszka Osiecka’s song ‘W żółtych płomieniach liści’ [‘In the Yellow Flames of Leaves’], which is often referred to as a rock song reflecting the events of March ’68.
Who or What Caused the Rise of Populism?
Authors: Tomšič Matevž 
Published: February 2025

Abstract
The article deals with who or what led to strengthening populist politics and its agents. This is a mutual combination of structural, cultural, political, media, etc. factors whereby one must recognise specifics in each country. However, the author pays special attention to the role of established elites, mainly political, but also others – i.e. business, intellectual and media in this respect. He claims that these elites bear a large part of the responsibility for the rise of populism because their irresponsibility, unresponsiveness and inefficiency in solving key social problems caused a sharp decline in trust in established politics and its leaders. This ‘lack of leadership’ offered populists a political ‘niche’ that some took advantage of.
How Active and Passive Social Media Engagement on Facebook and Instagram Shapes Democratic Attitudes Among Users in Slovakia
Authors: Baboš Pavol , Világi Aneta 
Published: February 2025

Abstract
Social media play an important role in the dissemination of political information and in political dialogue among agents, agencies and citizens. We study the effects of social media on democratic attitudes. Our analysis proceeds in two phases. First, we examine the effect of using eight social media platforms on support for democracy and liberal democratic principles. Second, we test the relationships between the intensity of six types of online political engagement on Facebook and Instagram and democratic attitudes. We employ linear and ordinal logistic regression analysis on a representative sample of 1,502 Slovak citizens aged 18 and older. We report three key findings: First, users of social media are not less supportive of democracy or liberal democratic principles. Second, passive political engagement on Facebook undermines support for liberal democratic principles. Third, active political engagement on both Facebook and Instagram is related to higher support for democracy as a regime but not for its liberal principles. In addition to the results on the effects of specific participatory activities, our study contributes by highlighting the need to differentiate between various types of democratic attitudes, different types of participation and different types of social media.
Human Immunodeficiency Virus Status Disclosure and Associated Factors among Children in the Pediatric Anti-Retroviral Therapy Clinic at Gambella Public Hospitals, Gambella Region, Southwest Ethiopia
Authors: Desta Abebe Ejigu , Mengesha Chernet Hailu , Mogas Solomon Berhanu 
Published: February 2025

Background
Globally, 1.7 million children are estimated to be living with HIV. As highly active antiretroviral therapy becomes progressively available in low resource settings, children are living longer and having longer survival times. Thus, one of the greatest psychosocial challenges that caregivers face is HIV- positive status disclosure to children which is becoming a common issue in clinical practice.

Objectives
To assess the magnitude and associated factors of disclosure among HIV- positive children in public hospitals in the ART clinic in Gambella town.

Materials and Methods
A facility- based cross- sectional study was performed using quantitative and qualitative data collection methods. The study was performed from March 10 to April 15, 2020 among 259 HIV- infected children aged 6-18 years and their caregivers in two public hospitals, in Gambella town. Bivariate and multivariate logistic regression analyses were applied to determine the factors associated with HIV status disclosure with a P-value <0.05 and a 95% confidence interval of the Adjusted odds ratio (AOR).

Results
Ninety-eight (37.8%) HIV-positive children were informed of their status. Biological fathers (AOR=5.37; 95%CI=2.18, 13.21); biological mothers (AOR=3.65; 95%CI=1.64, 8.15), and children aged ≥10 years (AOR=3.73; 95%CI=1.47, 9.49), duration of ART (11-16 years) (AOR=4.15; 95 %CI=1.55, 11.13) and adherence to ART treatment of child; good(AOR=3.33; 95%CI= 1.81, 6.13) were found to be significantly associated with HIV positive status disclosure to children.

Conclusion
The magnitude of disclosure of HIV- positive status to infected children was low. Caregiver’s relation with child, age of the child, duration of ART and adherence to ART treatment were associated with the disclosure of HIV-positive status in infected children. Therefore, age appropriate counseling and working on related factors are important for improving low disclosure.
PERANCANGAN APLIKASI PENGOLAHAN DATA SISWA BERBASIS JAVA PADA SD NEGERI 58 SALOLO
Authors: Ulvah Ulvah 
Published: February 2025

Penelitian ini bertujuan untuk membangun aplikasi pengolahan data siswa pada SD Negeri 58 Salolo. Aplikasi ini diharapkan dapat membantu dan memudahkan dalam pengolahan data siswa di sekolah. Penelitian ini dilaksanakan di SD Negeri 58 Salolo. Jenis penelitian yang digunakan dalam penelitian ini adalah Research and Development (R&D) dengan menggunakan metode pengembangan penelitian waterfall. Metode pengumpulan data yang dilakukan yaitu observasi, wawancara dan studi pustaka. Perancangan model sistem menggunakan pendekatan Unified Modeling Language (UML) yang terdiri dari Use Case Diagram, Activity Diagram, Sequence Diagram, dan Class Diagram. Hasil penelitian ini berupa aplikasi pengolahan data siswa yang dibangun menggunakan bahasa pemrograman Java, Netbeans IDE sebagai software pembuatan aplikasi, XAMPP sebagai web server database MySQL serta iReport untuk pembuatan laporan. Pengujian yang digunakan dalam sistem ini adalah menggunakan teknik pengujian black box, dimana semua tampilan dan fitur dalam sistem ini telah berfungsi dengan baik sehingga aplikasi ini dapat digunakan di sekolah SD Negeri 58 Salolo.