bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minimally Invasive Surgical Treatment of Hepatocellular Carcinoma: Long‐Term Outcome
Authors: Lai Eric C. H. , Tang Chung Ngai , Yang George P. C. , Li Michael K. W. 
Published: July 2009

AbstractBackgroundLaparoscopic liver resection for hepatocellular carcinoma (HCC) is still a matter of debate because of the uncertainty of the long‐term results and the fear of compromising the oncological resection. Published findings on survival and outcome after laparoscopic liver resection for HCC are scarce still. The aim of the present study was to report the perioperative and long‐term outcome of minimally invasive surgical treatment of HCC.MethodsFrom January 1998 to November 2008, all patients with HCC who underwent laparoscopic liver resection in our unit were included. A prospectively collected database was analyzed retrospectively. Perioperative outcome included procedure‐related morbidity and mortality. Long‐term outcome included 5‐year overall survival and disease‐free survival.ResultsDuring the study period, 30 consecutive patients with HCC underwent laparoscopic liver resection (hand‐assisted laparoscopic liver resection, n = 22; total laparoscopic liver resection, n = 7; converted to open approach, n = 1). The mean tumor size was 2.8 cm. The mean operating time was 139.4 min, and 90% of patients had R0 resection and 10% of patients had R1 resection. The hospital mortality and morbidity rates were 0 and 20%, respectively. The mean hospital stay was 7.4 days. For those patients (n = 22) with a minimal follow‐up of 24 months, the 5‐year overall and disease‐free survival rates were 50 and 36%, respectively. No port site recurrence occurred.ConclusionsThis study showed that laparoscopic liver resection for HCC was feasible and safe in selected patients. The long‐term survival was also favorable.
Patients with Less Than Three Episodes of Diverticulitis May Benefit from Elective Laparoscopic Sigmoidectomy
Authors: Rotholtz Nicolas A. , Montero Miguel , Laporte Mariano , Bun Maximiliano , Lencinas Sandra , Mezzadri Norberto 
Published: July 2009

AbstractBackgroundThis study was designed to asses the predictive factors of postoperative complications in patients who underwent a laparoscopic elective approach for recurrent diverticulitis and to determine the relationship between the number of acute episodes and surgical morbidity.MethodsA retrospective analysis was performed on patients with colonic diverticular disease treated by an elective laparoscopic approach between July 2000 and November 2007. The variables studied were age, sex, BMI, ASA, number of previous acute episodes, local severity, abdominal surgery history, comorbidity, and laparoscopic training of the surgeon. Logistic regression analysis was used to establish significant results.ResultsA total of 137 patients were analyzed; 87 (63.5%) were men with a mean age of 56.7 (range, 27–89) years. Intraoperative and postoperative complications occurred in 2.9% (n = 4) and 12.4% (n = 17) of the patients respectively. Conversion rate was 9.4% (n = 13). Local severity (odds ratio (OR), 16.34; 95% confidence interval (CI), 4.1–64.5, p = 0.00007), history of abdominal surgery (OR, 3.02; 95% CI, 0.8–11.5; p = 0.02), and the training of the operating surgeon (OR, 4.8; 95% CI, 1.02–22.7; p = 0.001) were significant risk factors related to surgery conversion. A history of three or more acute episodes was significantly associated with a high severity of local process and was a risk factor related to conversion (OR, 2.6; 95% CI, 0.5–12.3; p = 0.22). The severity of the local process seems to be a risk factor for perioperative complications. A significant association (χ2, 4.45; p = 0.03) between conversion and postoperative complications also was observed (OR: 3.79, 95% CI, 1.02–14.07; p = 0.04).ConclusionsA history of three or more acute episodes of diverticulitis with conservative treatment is associated with a high severity of the local process during laparoscopic sigmoidectomy and increases the rate of conversion and perioperative complications.
Preparation of Monodisperse Iron Oxide Nanoparticles via the Synthesis and Decomposition of Iron Fatty Acid Complexes
Authors: Chen Chih-Jung , Lai Hsin-Yi , Lin Chee-Cheng , Wang Jiun-Shen , Chiang Ray-Kuang 
Published: July 2009

Abstract
Iron fatty acid complexes (IFACs) are prepared via the dissolution of porous hematite powder in hot unsaturated fatty acid. The IFACs are then decomposed in five different organic solvents under reflux conditions in the presence of the respective fatty acid. The XRD analysis results indicate that the resulting NPs comprise a mixture of wustite, magnetite, and maghemite phases. The solvents with a higher boiling point prompt the formation of larger NPs containing wustite as the major component, while those with a lower boiling point produce smaller NPs with maghemite as the major component. In addition, it is shown that unstable NPs with a mixed wustite–magnetite composition can be oxidized to pure maghemite by extending the reaction time or using an oxidizing agent.
Substance use and abuse trajectories across adolescence: A latent trajectory analysis of a community‐recruited sample of girls
Authors: Marti C. Nathan , Stice Eric , Springer David W. 
Published: July 2009

ABSTRACTWe used data from a school‐based study of 496 adolescent girls to identify qualitatively distinct substance use and substance abuse developmental trajectory groups and tested whether the problematic groups differed from the non‐problematic groups on baseline and outcome validation variables. Results identified four substance use groups (late users, normative users, late‐heavy users, early‐heavy users) and four substance abuse groups (non‐abusers, moderate‐escalating abusers, moderate decreasing abusers, adolescent‐limited heavy abusers). Problematic substance use and abuse trajectory groups, relative to non‐problematic groups, showed elevations in baseline validation variables (age 14 delinquency, depressive symptoms, negative affectivity, parental support deficits, body dissatisfaction) and outcome validation variables (age 20 delinquency, depressive symptoms, social impairment, legal problems, school dropout, and substance abuse diagnosis), providing partial validation of this trajectory model.
Psychosocial, mechanical, and metabolic factors in adolescents’ musculoskeletal pain in multiple locations: A cross‐sectional study
Authors: Paananen Markus V. , Auvinen Juha P. , Taimela Simo P. , Tammelin Tuija H. , Kantomaa Marko T. , Ebeling Hanna E. , Taanila Anja M. , Zitting Paavo J. , Karppinen Jaro I. 
Published: July 2009

ABSTRACTRecent studies indicate that adolescents often experience musculoskeletal pains in two or more body locations. However, previous studies have mainly focused on localized pains, and the determinants of multiple musculoskeletal pains in adolescents are not well known. The present study was set to evaluate the role of psychosocial, mechanical, and metabolic factors in adolescents’ musculoskeletal pains in multiple locations. The study population consisted of the 1986 Northern Finland Birth Cohort; 15‐ to 16‐year‐old adolescents (n=6986), who responded to a mailed questionnaire in 2001. We assessed the associations of emotional and behavioral problems, physical activity, sitting time, sleeping time, overweight and smoking with musculoskeletal pains using multinomial logistic regression. Multiple pains were common, 23% of boys and 40% of girls reported feeling pain in at least three locations over the past 6 months. These pains were not only associated with anxious/depressed symptoms, withdrawn/depressed symptoms, somatic complaints, rule‐breaking and aggressive behavior, social problems, thought and attention problems, but also with high physical activity level, long sitting time, short sleeping time and smoking, among both boys and girls. In addition, pain in three to four locations associated with overweight in girls. A high number of psychosocial, mechanical and metabolic factors associated strongly with multiple pains. In conclusion, multiple musculoskeletal pains were strongly associated with psychosocial complaints, but also with mechanical and metabolic factors. Reported musculoskeletal pains in multiple locations in adolescence may have both peripheral (trauma, decreased regenerative ability) and central (sensitivity) causes.
Reciprocal influence on the incidence of symptoms in trigeminally and spinally innervated areas
Authors: Marklund Susanna , Wiesinger Birgitta , Wänman Anders 
Published: July 2009

ABSTRACTTemporomandibular disorders (TMD), headaches, and spinal pain show co‐morbidity and may therefore influence each other. The hypothesis tested is that the presence of any of these conditions will increase the risk of onset of new symptoms within a 2‐year period. The study population comprised 280 dental students, who were examined three times at 12‐month intervals. The incidence was calculated for a 2‐year period, based on subjects without the defined symptom at baseline. Each participant was classified into five different case‐control groups, representing incidence cases or no incidence (controls) of: (1) nonpain TMD symptoms; (2) jaw pain; (3) headaches; (4) spinal pain; and (5) TMD pain. Presence of headaches and of spinal pain and signs and symptoms of TMD at baseline were used as independent variables in logistic regression analyses, controlling for age and sex. Incidence cases with TMD pain reported spinal pain at baseline significantly more often than the controls, and were mostly women. Incidence cases with headaches and incidence cases with jaw pain significantly more often had signs of TMD and reported spinal pain at baseline, compared to controls. Incidence cases with nonpain TMD symptoms or spinal pain significantly more often presented with signs of TMD at baseline. Our findings show that pain and dysfunction in trigeminally innervated areas and pain in spinally innervated areas mutually predict the onset of new symptoms in dental students, indicating common pathophysiological mechanisms and individual vulnerability. This may be of importance in risk assessment and treatment planning of individuals with musculoskeletal pain.
Evaluating buyer–supplier relationship–performance spirals: A longitudinal study
Authors: Autry Chad W. , Golicic Susan L. 
Published: July 2009

AbstractInterorganizational relationships and their impact on firm performance have been studied at length in various business literatures, with many studies predicting that in dyadic exchange contexts strong relationships should lead to better performance for both parties involved. However, some studies reverse this causal ordering, arguing that the performance gains attributed to prior relational activity predict the strength of the dyadic relationship in future time periods. While supported, both of these perspectives on relationship strength/performance dynamics are incomplete, as the research studies are only cross‐sectional snapshots of the phenomenon. We remedy this gap in the existing literature by examining the dynamic cyclical linkage between relationship strength and performance of a buyer–supplier relationship in a longitudinal setting, using a relationship strength–performance spiral model. Results of testing a multiyear sample of 323 buyer–supplier relationships in the construction industry indicate not only that relationships tend to spiral positively following relationship initiation, but also that positive relationship spirals will self‐correct following multiple associations of alternating increases. These findings advance theory on buyer–supplier relationships, and provide insight for companies looking to improve supply chain outcomes through superior relationship management.
Analysis of Outcomes of Vascularized Flap Reconstruction in Patients with Advanced Mandibular Osteoradionecrosis
Authors: Alam Daniel S. , Nuara Michael , Christian James 
Published: July 2009

OBJECTIVETo examine outcomes of vascularized bone flap reconstruction of end‐stage osteoradionecrosis of the mandible.STUDY DESIGNCase series with planned data collection.SETTINGTertiary care academic hospital.SUBJECTSPatients with end‐stage radiation‐induced osteoradionecrosis (ORN) refractory to conservative therapy with wound complications including chronic infections, fistula formation, and pathologic fracture were included.RESULTSOutcomes of 33 patients were prospectively collected and analyzed, making this the largest series on this subject in the literature and the only one with planned data collection. Data on preoperative variables including radiation dose, sub‐site location, treatment date, and prior therapy, along with intraoperative issues and postoperative outcomes, were tracked and are presented. ORN was seen to develop in a bimodal distribution based on the timing of interval surgical intervention. The extent of local soft tissue injury often required the use of contralateral recipient vessels. Local wound complication rates were higher than that seen in primary reconstructions.CONCLUSIONSSuccessful reconstruction was achieved in all of the patients in this series. Long‐term resolution of infectious complication and disease resolution was seen in 91 percent of the patients in this series.
Importance of Treatment Institution in Head and Neck Cancer Radiotherapy
Authors: Kubicek Gregory J. , Wang Fen , Reddy Eashwar , Shnayder Yelizaveta , Cabrera Cristina E. , Girod Douglas A. 
Published: July 2009

OBJECTIVEThe treatment for head and neck cancer (HNC) often involves radiotherapy. Many HNC patients are treated at the academic center (AC) where the initial surgery or diagnosis was made. Because of the lengthy time course for radiotherapy, some patients are treated at community radiation facilities (non‐AC) rather than the AC despite potential AC advantages in terms of experience and technology. Our goal is to determine if these potential AC advantages correspond to a difference in treatment outcome.STUDY DESIGNHistorical cohort study.SETTINGUniversity of Kansas Medical Center, Kansas City, Kansas.SUBJECTS AND METHODSReview of records of patients with HNC cancers evaluated at the otolaryngology (ENT) department of an AC. Each patient's information and treatment characteristics were recorded, including radiotherapy treatment venue and treatment outcome.RESULTSThree hundred seventy‐four patients were analyzed, 263 were treated at an AC and 101 at a non‐AC. Patients treated at a non‐AC were more likely to present with earlier stage tumors, be treated with radiation alone rather than chemoradiotherapy, and be treated with adjuvant rather than primary radiotherapy. There was no difference in overall survival or recurrence rates between AC and non‐AC.CONCLUSIONPatients treated at an AC are more likely to have advanced stage tumors and receive chemoradiotherapy as their primary treatment. In analyses of matching patient subsets, there was no significant difference in patient outcomes. Patients can be treated at a non‐AC without affecting outcome compared with treatment at an AC.
Submental Flap for Reconstructing Tongue Defect with V‐Y Advancement Flap for Repairing Submental Defect
Authors: Chen Wei‐Liang , Yang Zhao‐Hui , Li Jing‐Song , Huang Zhi‐Quan , Wang Jian‐Guang , Zhang Bin 
Published: July 2009

OBJECTIVETo assess the reliability of the facial‐submental artery island flap for reconstructing tongue defects and the aesthetic benefits of using two V‐Y islanded flaps for repairing the resulting submental defect.STUDY DESIGNCase series with chart review.SETTINGPatient with tongue cancer, younger patient, cosmetic outcome.SUBJECTS AND METHODSThirty‐three tongue defects were repaired with facial‐submental artery island flaps, and the submental defects were repaired with two V‐Y advancement flaps. The ages of the patients ranged from 28 to 57 years; 19 were men and 14 were women. All of the lesions were tongue squamous cell carcinoma. The size of the facial‐submental artery island flap ranged from 3.5 × 7.0 to 5.0 × 8.0 cm. The size of the V‐Y advancement flaps ranged from 3.0 × 3.0 to 4.0 × 4.0 cm. Direct closure was achieved at all donor sites.RESULTSThe facial‐submental artery island flaps and V‐Y advancement flaps survived in 93.9 percent and 97.0 percent, respectively. The patients were followed for 12 to 26 months. The functional results in terms of speech and swallowing were good, and the aesthetic outcomes using two V‐Y advancement flaps to repair the submental defects were satisfactory. Two patients with extracapsular lymph node spread developed local recurrence: One is alive with disease and the other is dead.CONCLUSIONSThe facial‐submental artery island flap is a simple, reliable flap that is preferred for reconstructing tongue defects. Using two V‐Y advancement flaps for repairing the donor site defect improves the cosmetic outcome in the submental region.
Partial Cricotracheal Resection in Children
Authors: George Mercy , Ikonomidis Christos , Jaquet Yves , Monnier Philippe 
Published: July 2009

OBJECTIVESTo delineate the various factors contributing to failure or delay in decannulation after partial cricotracheal resection (PCTR) in children.STUDY DESIGNCase series.SETTINGAcademic tertiary medical center.SUBJECTS AND METHODSA retrospective case review of 100 children who underwent PCTR between 1978 and 2008 for severe subglottic stenosis using an ongoing database.RESULTSNinety of 100 (90%) patients were decannulated. Six patients needed secondary tracheostomy. The results of the preoperative evaluation showed grade II stenosis in four patients, grade III in 64 patients, and grade IV in 32 patients. The overall decannulation rate was 100 percent in grade II, 95 percent in grade III, and 78 percent in grade IV stenosis. Fourteen (14%) patients required revision open surgery. The most common cause of revision surgery was posterior glottic stenosis. Partial anastomotic dehiscence was seen in four patients. Delayed decannulation (>1 year) occurred in nine patients. Overall mortality rate in the whole series was 6 percent. No deaths were directly related to the surgery. No iatrogenic recurrent laryngeal nerve injury was present in the entire series.CONCLUSIONComorbidities and associated syndromes should be addressed before PCTR is planned to improve the final postoperative outcome in terms of decannulation. Perioperative morbidity due to anastomotic dehiscence, to a certain extent, can be avoided by intraoperative judgment in the selection of double‐stage surgery when more than five tracheal rings need to be resected. Subglottic stenosis with glottic involvement continues to pose a difficult challenge to pediatric otolaryngologists, often necessitating revision procedures.
Head and Neck Squamous cell Carcinoma Targeted Chemosensitization
Authors: Figures Mindy R. , Wobb Jessie , Araki Koji , Liu Tingyan , Xu Lei , Zhu Hanjing , O'Malley Bert W. , Li Daqing 
Published: July 2009

OBJECTIVEThe current treatment for advanced head and neck squamous cell carcinoma continues to result in poor outcomes. The purpose of this study is to investigate the benefit of fibroblast growth factor 2‐targeted adenovirus‐mediated mutant‐Rad50 (FGF2‐Ad‐Rad50) gene transfer in enhancing chemosensitization for head and neck squamous cell carcinoma and reducing chemotoxicity.STUDY DESIGNRandomized controlled laboratory study.SETTINGUniversity of Pennsylvania, Philadelphia, PA.SUBJECTS AND METHODSHuman head and neck squamous cell carcinoma tumor cells and a mouse model with human head and neck squamous cell carcinoma were used for this study. There were five mice in each study group. FGF2‐fab' molecule was conjugated with an adenoviral mutant‐Rad50 construct. FGF2‐targeted transgene expression efficiency was evaluated in vitro. Tumor cytotoxicity and growth inhibition were examined after combined FGF2‐Ad‐Rad50 with cisplatin treatment in vitro and in vivo. Anti‐tumor mechanisms were investigated.RESULTSFGF2‐targeted gene transfer approach significantly improved transgene expression in head and neck squamous cell carcinoma tumor cells over a nontargeted approach (207.51 ± 33.62 vs 51.44 ± 8.28, respectively). FGF2‐Ad‐Rad50 with cisplatin demonstrated a superior tumor suppression effect (264.5 ± 124.1 mm3 vs 567.1 ± 267.6 mm3), increased DNA double‐strand breaks (1349 ± 51.67 vs 774 ± 28.56), and anti‐angiogenesis (%ROI: 0.76% ± 0.38% vs 2.10% ± 1.66%) in tumor cells over nontargeted adenovirus.CONCLUSIONCombination of FGF2‐Ad‐Rad50 with cisplatin significantly improves anti‐tumor effect by targeting DNA repair systems and tumor angiogenesis. The great benefit of this strategy supports clinical trial for novel treatment of head and neck squamous cell carcinoma.
Deep Brain Stimulation Effects in Patients with Tinnitus
Authors: Shi Yongbing , Burchiel Kim J. , Anderson Valerie C. , Martin William Hal 
Published: July 2009

OBJECTIVETo report deep brain stimulation (DBS) effects in patients with tinnitus.STUDY DESIGNCase series with chart review.SETTINGTertiary medical center.SUBJECTS AND METHODSSeven patients implanted with DBS systems for movement disorders who also reported having tinnitus were interviewed about their tinnitus conditions. Four were available for testing in a specialized tinnitus clinic with their DBS systems turned off or on. Testing included matching of self‐rated and psychoacoustically measured tinnitus loudness to measure the impact of DBS on tinnitus.RESULTSThree of the seven patients reported reduced tinnitus loudness when DBS was turned on. Of the four patients tested in the clinic, results indicated that DBS of the ventralis intermedius nucleus of the thalamus caused decreases in tinnitus loudness in two patients with relatively prolonged residual inhibition.CONCLUSIONThese results suggest that DBS of nonauditory thalamus structures may provide tinnitus relief for some patients.
Intratympanic methylprednisolone injections for subjective tinnitus
Authors: Topak M , Sahin-Yilmaz A , Ozdoganoglu T , Yilmaz H B , Ozbay M , Kulekci M 
Published: July 2009

AbstractObjectives:This study aimed to determine whether intratympanically injected methylprednisolone is effective in treating subjective tinnitus refractory to medical treatment.Study design:Prospective, randomised, placebo-controlled, single-blinded study.Methods:Seventy adult patients with subjective tinnitus of cochlear origin were randomly assigned to receive intratympanic injection of either methylprednisolone or saline solution. The treatment protocol comprised three intratympanic injections, one per week for three weeks. Improvement in tinnitus severity was measured by a self-rated tinnitus loudness scale and by the tinnitus severity index, at baseline and two weeks after the last injection.Results:Data for 59 patients were available for analysis. There was no significant difference between the two treatment groups regarding age, sex, pure tone average, pretreatment tinnitus intensity, tinnitus laterality or tinnitus duration. There was a significant post-treatment improvement in self-rated tinnitus loudness scale results in both groups. No significant post-treatment changes in the tinnitus severity index individual and total scores were observed in either group. The most frequently encountered side effects were pain during injection, vertigo, a burning sensation around the ear and in the throat, and a bitter taste. A burning sensation and bitter taste were observed more often in the methylprednisolone group compared with the placebo groupConclusion:The results of this study indicate that intratympanic methylprednisolone has no benefit, compared with placebo, for the treatment of subjective tinnitus of cochlear origin refractory to medical treatment.