bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with the appearance of gingival papillae
Authors: Chow Yiu Cheung , Eber Robert M. , Tsao Yi‐Pin , Shotwell Jeffrey L. , Wang Hom‐Lay 
Published: July 2010

Chow YC, Eber RM, Tsao Y‐P, Shotwell JL, Wang H‐L. Factors associated with the appearance of gingival papillae. J Clin Periodontol 2010; 37: 719‐727 doi: 10.1111/j.1600-051X.2010.01594.x. AbstractAim:The purpose of this study was to evaluate factors associated with the fill of inter‐dental spaces by gingival papillae.Materials and Methods: Ninety‐six adult subjects were evaluated. Papilla score (PS), tooth form/shape, interproximal contact length and gingival thickness were recorded for 672 maxillary anterior and first pre‐molar interproximal sites. Statistical analyses included a non‐parametric χ2 test, anova, the Mixed Procedure for SAS and Pearson's correlation coefficient (r).Results: Papilla deficiency was more frequent in older subjects (p<0.05), as papilla height decreased 0.012 mm with each year of increasing age (p<0.05). Competent papillae (complete fill inter‐dentally) were associated with: (1) crown width: length 0.87; (2) proximal contact length 2.8 mm; (3) bone crest‐contact point ≤5 mm; and (4) interproximal gingival tissue thickness 1.5 mm. Gingival thickness correlated negatively with PS (r=−0.37 to −0.54) and positively with tissue height (r=0.23–0.43). Tooth form (i.e. crown width to length ratio) correlated negatively with PS (r=−0.37 to −0.61). Other parameters failed to show any significant effects.Conclusions: Gingival papilla appearance was associated significantly with subject age, tooth form/shape, proximal contact length, crestal bone height and interproximal gingival thickness.
Validation of human periodontal ligament‐derived cells as a reliable source for cytotherapeutic use
Authors: Iwata Takanori , Yamato Masayuki , Zhang Zheng , Mukobata Shigeki , Washio Kaoru , Ando Tomohiro , Feijen Jan , Okano Teruo , Ishikawa Isao 
Published: July 2010

Iwata T, Yamato M, Zhang Z, Mukobata S, Washio K, Ando T, Feijen J, Okano T, Ishikawa I. Validation of human periodontal ligament‐derived cells as a reliable source for cytotherapeutic use. J Clin Periodontol 2010; doi: 10.1111/j.1600‐051X.2010.01597.x.AbstractAim: Periodontal ligament (PDL) is a reliable cell source for periodontal regeneration. In this study, an optimal protocol for the extraction, expansion, and characterization of human PDL (hPDL) cells was examined for clinical trials.Materials and Methods: hPDL tissues were obtained from 41 surgically extracted teeth and digested with enzymes. Human adipose‐derived stem cells (hADSCs), bone marrow‐derived mesenchymal stem cells (hBMMSCs), and gingival fibroblasts (hGFs) were used for comparison. For each sample, the proliferative capacity, colony‐forming ability, alkaline phosphatase activity, differentiation ability, the cell surface antigens, gene expression, and regenerative potential were examined.Results: hPDL cells were more successfully extracted with collagenase/dispase [29/30 (96.7%)] than with trypsin/EDTA [8/11 (72.7%)], and exhibited osteogenic potential both in vitro and in vivo. The proliferation of hPDL cells was rapid at a low cell density. hPDL cells frequently differentiated into cementoblastic/osteoblastic lineage (∼60%). In contrast, their adipogenic and chondrogenic potentials were lower than those of hADSCs and hBMMSCs. Some genes (NCAM1, S100A4, and periostin) were preferentially expressed in hPDL cells compared with those of hBMMSCs and hGFs. Immunohistochemical studies revealed the expressions of S100A4 and periostin in hPDL tissue.Conclusion: A protocol for the successful cultivation and validation of hPDL cells is proposed for clinical settings.
Progress in allogeneic transplantation for multiple myeloma
Authors: Gahrton Gösta 
Published: July 2010

AbstractAllogeneic hematopoietic stem cell transplantation to treat multiple myeloma has been attempted since the early 1980s. The original conditioning regimen including high‐dose total body irradiation (TBI) plus cyclophosphamide was myeloablative and associated with a relatively low relapse/progression rate, but high transplant‐related mortality and no obvious improvement in progression‐free survival or overall survival. Some risk groups may benefit from this transplant modality and occasional patients may be cured, but due to the high‐transplant‐related mortality it is mainly abandoned. Reduced intensity conditioning (RIC), non‐myeloablative allogeneic transplantation reduces transplant‐related mortality significantly when compared with myeloablative conditioning, but the relapse/progression rate is somewhat higher. However although the treatment‐related mortality is higher than after autologous transplantation, the progression‐free and overall survival was better or tended to be better in three of five prospective trials comparing tandem autologous/RIC allogeneic transplantation to single or tandem autotransplantation due to lower relapse/progression rate. Adding donor lymphocyte infusions post‐transplant, new drugs like bortezomib, thalidomide, lenalidomide or pomalidomide pre‐ and/or post‐transplant, and more specific antimyeloma cell therapy like NK cells post‐transplant, may in future studies prove to improve results.
Microbial translocation in simian immunodeficiency virus (SIV)‐infected rhesus monkeys (Macaca mulatta)
Authors: Leinert C. , Stahl‐Hennig C. , Ecker A. , Schneider T. , Fuchs D. , Sauermann U. , Sopper S. 
Published: July 2010

AbstractBackground  Chronic immune activation is a hallmark of HIV infection and has been postulated as major factor in the pathogenesis of AIDS. Recent evidence suggests that activation of immune cells is triggered by microbial translocation through the impaired gastrointestinal barrier.Methods  To determine the association between microbial translocation and disease progression, we have retrospectively analyzed microbial products, viral load and markers of immune activation in a cohort of 37 simian immunodeficiency virus‐infected rhesus monkeys, divided in two groups with distinct disease courses.Results  As seen in HIV‐infected patients, we found elevated levels of lipopolysaccharide (LPS) in infected animals. However, LPS levels or LPS control mechanisms like endotoxin core antibodies or LPS‐binding protein did not differ between groups with different disease progression. In contrast, neopterin, a metabolic product of activated macrophages, was higher in fast progressors than in slow progressors.Conclusion  Our data indicate that translocation of microbial products is not the major driving force of immune activation in HIV infection.
Motor function and methylphenidate effect in children with attention deficit hyperactivity disorder
Authors: Stray Liv Larsen , Ellertsen Bjørn , Stray Torstein 
Published: July 2010

AbstractAim:  Hyperactivity, impulsivity and poor attention are the core problems of ADHD and central stimulant medication is the preferred treatment. Many children with ADHD also display motor problems. The present study investigated the presence of motor problems in subjects who showed positive response to central stimulants on ADHD symptoms, compared with non‐responders.Method:  This is a retrospective study of 73 children diagnosed ADHD, aged 5–17 years, who had been assessed with parts of the ‘Motor Function Neurological Assessment’ (MFNU) and evaluated with regard to effect of central stimulant medication. The sample was divided into two subgroups based on the responses to methylphenidate: Medicine responders and Non medicine responders.Results:  Stimulant responders showed significantly more motor problems than the non‐responders on all sub‐tests and on the total problem score of the MFNU. Motor problems were present both in younger (age 5–10 years) and older (11–17 years) stimulant responders. There were no gender differences in motor performance.Conclusion:  Our findings indicate that the probability of positive effect of central stimulants on core problems of ADHD is higher when motor problems are present in addition to ADHD symptoms, than when motor problems are absent.
Renal function and volume of infants born with a very low birth‐weight: a preliminary cross‐sectional study
Authors: Zaffanello M , Brugnara M , Bruno C , Franchi B , Talamini G , Guidi G , Cataldi L , Biban P , Mella R , Fanos V 
Published: July 2010

AbstractAim:  The aim of our study was to compare the function and volumes of kidneys of very low birth‐weight (VLBW) and of extremely low birth‐weight (ELBW) infants at pre‐school ages.Patients and methods:  We did a revision of the neonatal records of infants born in our hospital that weighed ≤1500 g at birth. The children were divided into two groups according to their weight at birth: ELBW (<1000 g) and VLBW (1000–1500 g). At the age of 5.7 ± 1.4 years, the children underwent clinical, laboratory and ultrasound renal assessments.Results:  Sixty‐nine children fulfilled the requirements for the study. The rate of neonatal treatment with aminoglycosides was higher in ELBW preterms. Renal function parameters, i.e. estimated glomerular filtration rate and albuminuria, did not differ between the two groups of children. Urinary α1‐microglobulin excretion was significantly higher and kidneys were significantly smaller in the ELBW group than in the VLBW group.Conclusion:  No impairment or differences in renal parameters were found in pre‐school children born ELBW compared with those born with VLBW, except for differences in kidney volume, renal cortical thickness and urinary α1‐microglobulin excretion. Thus, patients born with ELBW would require a longer follow‐up period.
Lactate dehydrogenase predicts hypoxic ischaemic encephalopathy in newborn infants: a preliminary study
Authors: Karlsson Mathias , Wiberg‐Itzel Eva , Chakkarapani Ela , Blennow Mats , Winbladh Birger , Thoresen Marianne 
Published: July 2010

AbstractBackground:  Enzyme leakage as a result of hypoxia‐ischaemia induced cell damage in affected organs is seen together with hypoxic ischaemic encephalopathy (HIE) after perinatal asphyxia.Aim:  To investigate whether plasma lactate dehydrogenase [LDH], alanine aminotransferase [ALT] and aspartate aminotransferase [AST] during the first 12 h after birth predict HIE and adverse neurodevelopment outcome in newborn term infants with intra‐partum signs of foetal distress.Methods:  Enzymes were measured within 12 h post partum in newborn infants with differing degree of HIE (n = 41) and in infants with signs of foetal distress during birth (n = 205) without HIE (non‐HIE group). All infants were randomized into two groups. One group (n = 123) was used for calculation of cut off limits for the enzymes studied and the other group (n = 123) was used for calculation of the predictive value of the enzymes for detection of HIE.Results:  Using ROC curves, a cut off level of 1049 U/L for [LDH] was the best predictor of HIE (sensitivity 100% and specificity 97%) but also for long term outcome after HIE.Conclusion: [LDH] is a good predictor of HIE during the first 12 h after birth. This result is of clinical interest offering a potential inexpensive and safe prognostic marker in newborn infants with perinatal asphyxia.
The development of the subplate and thalamocortical connections in the human foetal brain
Authors: Kostović Ivica , Judaš Miloš 
Published: July 2010

AbstractThe aim of this review is to present clinically relevant data on prenatal development of thalamocortical connections in the human brain. The analysis is based on extensive Zagreb Neuroembryological Collection, including more than 500 prenatal human brains stained with various classical neurohistological, as well as modern histochemical and immunohistochemical methods. The connection of thalamocortical axons during the ‘waiting’ period with transient cortical subplate zone and subsequent synaptic engagement in the cortical plate is the main connectivity event in the late foetus and preterm infant. This connectivity is the structural substrate for the endogeneous subplate and sensory‐driven circuitry generating transient electrical phenomena and may represent a transient network in the developmental history of consciousness.Conclusion:  Findings presented in this review should be considered in the management of pain in preterm infants, in searching for the vulnerability of the subplate zone in diagnostic procedures using the in vivo MRI and in revealing the developmental origin of cognitive and mental disorders.
The diuretic bumetanide decreases autistic behaviour in five infants treated during 3 months with no side effects
Authors: Lemonnier Eric , Ben‐Ari Yehezkel 
Published: July 2010

AbstractThe inhibitory transmitter GABA has been suggested to play an important role in infantile autistic syndrome (IAS), and extensive investigations suggest that excitatory actions of GABA in neurological disorders are because of a persistent increase of [Cl−]I.Aims:  To test the effects of the chloride co‐transporter NKCC1 diuretic compound Bumetanide that reduces [Cl−]I on IAS.Methods:  Bumetanide was administered daily (1 mg daily) during a 3 ‐month period and clinical and biological tests made. We used 5 standard IAS severity tests ‐ Childhood Autism Rating Scale, Aberrant Behaviour Checklist, Clinical Global Impressions; Repetitive and Restrictive Behaviour and the Regulation Disorder Evaluation Grid.Results:  We report a significant improvement in IAS with no side effects.Conclusion:  Bumetanide decreases autistic behaviour with no side effects suggesting that diuretic agents may exert beneficial effects on IAS and that alterations of the actions of GABA may be efficient in IAS treatment calling for large scale randomized trials.
Towards an Epistolary Discourse: Receiving the Eighteenth‐Century Letter
Authors: Van Hensbergen Claudine 
Published: July 2010

AbstractThis article suggests the significance of letters as texts in the long 18th century. It provides a survey of past and present critical approaches to letters in the period, and outlines the various ways in which scholars use letters in their research. The article argues against the tendency to conceive of the letter as a distinct literary genre, and rather suggests that scholars should think in terms of a broader epistolary discourse.
‘The Excellencies of the Female Character’: Anna Seward’s Censored Sermon
Authors: Barnard Teresa 
Published: July 2010

AbstractTowards the end of her life, the eighteenth‐century writer, Anna Seward, made meticulous preparations for the publication of her complete works of poetry, choosing her literary colleague, Walter Scott, as her editor. Following conventions, she included a range of autobiographical correspondence and prose writings as a means of self‐expression. Within this compilation is a collection of sermons written for her father, Thomas, who was the canon of Lichfield Cathedral, and for his parish curates in Derbyshire and Staffordshire. However, the sermons were never published, being excised by Scott because her family and executors considered them to be ‘nearly the reverse of what that solemn order of Composition should be’. They were just too subversive for publication by a woman. Among the sermons is a remarkably radical piece, written specifically for annual delivery in Lichfield cathedral by a senior clergyman to the Ladies’ Charitable Society. Yet Seward was by no means pious. Her early adulthood saw a series of battles against her father when she was drawn towards dissenting religions. The sermon is more sisterly than religious, more literary than devout. She uses considerable intellectual dexterity to urge ‘her’ congregation towards a life more independent. Neither parishioners nor minister knew the author was female. Using a text from Proverbs, Seward skilfully juxtaposes the idea of Lemuel as transmitter of his mother’s wisdom on the subject of worthy women, with the Cathedral minister as transmitter of her own thoughts on the ‘excellencies’ of women and their important role in society. The sermon’s content is both a literary expression of self‐identity and of the wider implications of women intervening in traditionally masculine areas, specifically in the Anglican Church. Seward’s identity was, in effect, surrended to her editors and what remains is nowhere near the complete picture. But this narrative is part‐sermon, part‐polemics, as she sets herself above ‘her’ congregation, employs her literary skills and uses the minister as her mouthpiece to encourage women away from domesticity.
‘The Della Cruscans: A Survey of the Criticism and Resources, 1956–2009’
Authors: Broadhead Alex 
Published: July 2010

AbstractThe last 14 years have witnessed an unprecedented surge of critical interest in the Della Cruscans, a coterie of writers (including Robert Merry and Mary Robinson) who enjoyed a short‐lived period of considerable popularity in the late eighteenth century. Prior to the publication of Jerome McGann’s article, ‘The Literal World of the English Della Cruscans’ in 1995, only two studies of the group had been published, in 1956 and 1967, respectively. With the exception of these works, the group had been all but forgotten, and the few existing references to their work in literary histories and encyclopaedias had invariably been dismissive. More successfully than the two critics who preceded him, McGann reclaimed the Della Cruscans as a group worthy of scholarly attention, providing a sympathetic outline of their poetics and emphasising the integral role they played in the development of British romantic poetry. The response to McGann’s positive reappraisal of the group was enthusiastic, and the resulting studies advanced it in a number of different directions, although all shared an interest in the perceived transgressiveness of Della Cruscanism and the role of the satirist William Gifford in their historical devaluation. This article aims to provide a survey of all of the criticism on the movement and some of the currently available primary resources, beginning with earliest published article in 1956 and culminating with the most recent of the post‐McGann studies. It concludes by suggesting some new directions that the ongoing revaluation of the movement might take over the course of the next few years.
Effect of telephone follow‐up on adherence to a diabetes therapeutic regimen
Authors: NESARI Maryam , ZAKERIMOGHADAM Masoumeh , RAJAB Asadollah , BASSAMPOUR Shiva , FAGHIHZADEH Soghrat 
Published: July 2010

AbstractAim:  To determine whether a nurse telephone follow‐up service could improve the level of adherence to a diabetes therapeutic regimen for patients with type 2 diabetes.Methods:  A total of 61 patients attended a 3 day diabetes self‐care program at the Iranian Diabetes Society. They were randomly assigned to one of the experimental or control groups. A telephone follow‐up program was applied to the experimental group for 3 months, twice per week for the first month and weekly for the second and third months. The data‐collection instruments included a data sheet to record the glycosylated hemoglobin (HbA1c) level and a questionnaire. The data were collected at baseline and after 12 weeks.Results:  There were significant differences between the control and the experimental groups in their adherence to a diabetic diet, exercise, foot care, blood glucose monitoring, and medication‐taking. Also, the HbA1c levels differed significantly between the two groups after 3 months.Conclusion:  A nurse‐led telephone follow‐up was effective in enhancing the level of adherence to a diabetes therapeutic regimen, such that the HbA1c level decreased.
Association of COL11A2 polymorphism with susceptibility to Kawasaki disease and development of coronary artery lesions
Authors: Sheu J. J. , Lin Y. J. , Chang J. S. , Wan L. , Chen S. Y. , Huang Y. C. , Chan C. , Chiu I. W. , Tsai F. J. 
Published: July 2010

SummaryKawasaki disease (KD) is a pediatric systemic vasculitis of unknown etiology wherein genetic influence is suspected. Gene clusters within the HLA region at chromosome 6p21.3 have been linked to KD and other autoimmune disorders. As collagen is a strong autoantigen inducing chronic inflammation in patients with vasculitis, this study tests a hypothesis that single‐nucleotide polymorphism (SNP) of a collagen gene, COL11A2, located in this HLA region may affect susceptibility to Kawasaki disease and its arterial sequels. SNP sites rs2294478 (at promoter) and rs2076311 (at intron 19) were genome‐typed on 93 KD patients and 680 healthy subjects. Genotypic and allelic frequencies analyses found A allele at rs2076311 as a risk allele for KD. Clinical association study showed protective potential of C/C genotype at rs2294478 and A/A at rs2076311 for developing coronary artery lesions (CALs) in patients. In addition, C‐A haplotype of COL11A2 gene associates with KD development and can serve as a genetic marker to differentiate KD patients lacking CALs from those with such lesions. Our findings suggest the involvement of genetic variations of COL11A2 in Kawasaki disease and CAL formation.
On the Conditions for Antipassives
Authors: Spreng Bettina 
Published: July 2010

AbstractThis survey of the triggers for Antipassives compares the most commonly known conditions under which Antipassive and accusative configurations occur in ergative and split‐ergative languages. It is shown that Antipassives and accusative configurations are triggered by similar if not identical semantic conditions. These conditions are always in contrast to the conditions for ergative configurations. A comparison of those triggers in accusative languages shows that they follow parallel patterns. It is confirmed that changes in case configurations are triggered by similar semantic properties, regardless of the typological corner a language comes from.
Flood Knowledge and Management in Bangladesh: Increasing Diversity, Complexity and Uncertainty
Authors: Cook Brian R. 
Published: July 2010

AbstractThe purpose of this paper is to review and discuss the relationship between government publications and academic studies of flood management in Bangladesh. The paper reviews these literatures while also emphasizing the assumptions, objectives and national issues that have influenced modern flood management. This approach aims to engage with the evolving knowledges used to inform and to criticize flood management in one of the most flood‐prone nations on earth. The analysis suggests a disconnection between government and academic knowledge, particularly concerning the characterization of government objectives within the academic discourse. The paper is divided into four periods in which the objectives, methods and understandings were fundamentally reoriented, contributing to the current discrepancy between government and academic approaches to flooding and flood management. The paper concludes with discussion of three issues related to the competing assumptions of flood risk management in Bangladesh and raises the issue of growing complexity in relation to hazards management.
Barriers to Collaborative Governance in New Zealand Fisheries: Pt I
Authors: Ali Memon P. , Kirk Nicholas A. 
Published: July 2010

AbstractRecurrent ecological crises in fisheries throughout the world make it imperative that a fundamental re‐alignment of institutional arrangements occurs in order to promote sustainability. Collaborative institutional arrangements that provide incentives for collective action are seen as a more effective way to solve this problem than the more traditional hierarchical regulatory or market led approaches used in the past. While the merits of devolved collaborative governance have been stressed in recent fisheries literature, this paper is the first in a series of two which attempt to critically examine the barriers which impede collaboration in fisheries, using a New Zealand case study. This first paper introduces the New Zealand fisheries context, and continues with a literature review of the theories underpinning collaborative management with insights from the current debates on localised governance of natural resources informed by institutional analysis approaches.