bluuebunny/crossref_metadata_2025_split huggingface dataset:
From bristle to brain: embryonic development of topographic projections from basiconic sensilla in the antennal nervous system of the locust Schistocerca gregaria
Authors: Boyan George , Ehrhardt Erica 
Published: May 2024

AbstractThe antennal flagellum of the locust S. gregaria is an articulated structure bearing a spectrum of sensilla that responds to sensory stimuli. In this study, we focus on the basiconic-type bristles as a model for sensory system development in the antenna. At the end of embryogenesis, these bristles are found at fixed locations and then on only the most distal six articulations of the antenna. They are innervated by a dendrite from a sensory cell cluster in the underlying epithelium, with each cluster directing fused axons topographically to an antennal tract running to the brain. We employ confocal imaging and immunolabeling to (a) identify mitotically active sense organ precursors for sensory cell clusters in the most distal annuli of the early embryonic antenna; (b) observe the subsequent spatial appearance of their neuronal progeny; and (c) map the spatial and temporal organization of axon projections from such clusters into the antennal tracts. We show that early in embryogenesis, proliferative precursors are localized circumferentially within discrete epithelial domains of the flagellum. Progeny first appear distally at the antennal tip and then sequentially in a proximal direction so that sensory neuron populations are distributed in an age-dependent manner along the antenna. Autotracing reveals that axon fasciculation with a tract is also sequential and reflects the location and age of the cell cluster along the most distal annuli. Cell cluster location and bristle location are therefore represented topographically and temporally within the axon profile of the tract and its projection to the brain.
Predicting response of hepatoblastoma primary lesions to neoadjuvant chemotherapy through contrast-enhanced computed tomography radiomics
Authors: Yang Yanlin , Wang Haoru , Si Jiajun , Zhang Li , Ding Hao , Wang Fang , He Ling , Chen Xin 
Published: May 2024

Abstract
Objective
To investigate the clinical value of contrast-enhanced computed tomography (CECT) radiomics for predicting the response of primary lesions to neoadjuvant chemotherapy in hepatoblastoma.

Methods
Clinical and CECT imaging data were retrospectively collected from 116 children with hepatoblastoma who received neoadjuvant chemotherapy. Tumor response was assessed according to the Response Evaluation Criteria in Solid Tumors (RECIST). Subsequently, they were randomly stratified into a training cohort and a test cohort in a 7:3 ratio. The clinical model was constructed using univariate and multivariate logistic regression, while the radiomics model was developed based on selected radiomics features employing the support vector machine algorithm. The combined clinical–radiomics model incorporated both clinical and radiomics features.

Results
The area under the curve (AUC) for the clinical, radiomics, and combined models was 0.704 (95% CI: 0.563–0.845), 0.830 (95% CI: 0.704–0.959), and 0.874 (95% CI: 0.768–0.981) in the training cohort, respectively. In the validation cohort, the combined model achieved the highest mean AUC of 0.830 (95% CI 0.616–0.999), with a sensitivity, specificity, accuracy, precision, and f1 score of 72.0%, 81.1%, 78.5%, 57.2%, and 63.5%, respectively.

Conclusion
CECT radiomics has the potential to predict primary lesion response to neoadjuvant chemotherapy in hepatoblastoma.
Investigating oral somatosensory perception and oral symptoms of head and neck cancer patients: insights on eating behaviour
Authors: Riantiningtyas Reisya Rizki , Dougkas Anestis , Bredie Wender L. P. , Kwiecien Camille , Bruyas Amandine , Philouze Pierre , Giboreau Agnès , Carrouel Florence 
Published: May 2024

Abstract
Purpose
Sensory alterations and oral manifestations are prevalent among head and neck cancer (HNC) patients. While taste and smell alterations have been thoroughly investigated, studies on their oral somatosensory perception remain limited. Building upon our previous publication that primarily focused on objective somatosensory measurements, the present work examined self-reported sensory perception, including somatosensation and oral symptoms, in HNC patients and evaluated their link with eating behaviour.

Methods
A cross-sectional study was conducted using self-reported questionnaires on sensory perception, oral symptoms, sensory-related food preference, and eating behaviour among HNC patients (n = 30). Hierarchical clustering analysis was performed to categorise patients based on their sensory perception. Correlations between oral symptoms score, sensory perception, sensory-related food preference, and eating behaviour were explored.

Results
Two distinct sensory profiles of patients were identified: no alteration (n = 14) and alteration (n = 16) group. The alteration group showed decreased preference towards several sensory modalities, especially the somatosensory. Concerning eating behaviour, more patients in the alteration group agreed to negatively connotated statements (e.g. having food aversion and eating smaller portions), demonstrating greater eating difficulties. In addition, several oral symptoms related to salivary dysfunction were reported. These oral symptoms were correlated with sensory perception, sensory-related food preference, and eating behaviour.

Conclusion
This study presented evidence demonstrating that sensory alterations in HNC patients are not limited to taste and smell but cover somatosensory perception and are linked to various aspects of eating. Moreover, patients reported experiencing several oral symptoms. Those with sensory alterations and oral symptoms experienced more eating difficulties.
pDNA-tachyplesin treatment stimulates the immune system and increases the probability of apoptosis in MC4-L2 tumor cells
Authors: Mahmoudi-Filabadi Fatemeh , Doosti Abbas 
Published: May 2024

AbstractBreast cancer is the most common cancer among women worldwide, and marine creatures are the most abundant reservoir of anticancer medicines. Tachyplesin peptides have shown antibacterial capabilities, but their potential to inhibit cancer growth and trigger cancer cell death has not been investigated. A synthetic tachyplesin nucleotide sequence was generated and inserted into the pcDNA3.1( +) Mammalian Expression Vector. PCR analysis and enzyme digesting procedures were used to evaluate the vectors' accuracy. The transfection efficiency of MCF-7 and MCF10-A cells was 57% and 65%, respectively. The proliferation of MCF-7 cancer cells was markedly suppressed. Administration of plasmid DNA (pDNA) combined with tachyplesin to mice with tumors did not cause any discernible morbidity or mortality throughout treatment. The final body weight curves revealed a significant reduction in weight among mice treated with pDNA/tachyplesin and tachyplesin at a dose of 100 µg/ml (18.4 ± 0.24 gr, P < 0.05; 11.4 ± 0.24 gr P < 0.01) compared to the control group treated with PBS (22 ± 0.31 gr). Animals treated with pDNA/tachyplesin and tachyplesin exhibited a higher percentage of CD4 + Foxp3 + Tregs, CD8 + Foxp3 + Tregs, and CD4 + and CD8 + T cell populations expressing CTLA-4 in their lymph nodes and spleen compared to the PBS group. The groups that received pDNA/tachyplesin exhibited a substantial upregulation in the expression levels of caspase-3, caspase-8, BAX, PI3K, STAT3, and JAK genes. The results offer new possibilities for treating cancer by targeting malignancies using pDNA/tachyplesin and activating the mTOR and NFκB signaling pathways.
Treatment of multiple adjacent gingival recessions using leucocyte- and platelet-rich fibrin with coronally advanced flap: a 12-month split-mouth controlled randomized clinical trial
Authors: Yavuz Atacan , Güngörmek Hatice Selin , Kuru Leyla , Doğan Başak 
Published: May 2024

Abstract
Objective
This split-mouth randomized study aimed to assess efficacy of leucocyte-platelet-rich fibrin (L-PRF) versus connective tissue graft (CTG) in achieving root coverage (RC) for multiple adjacent gingival recessions (MAGRs) throughout 12-month period.

Materials and methods
The study enrolled 59 teeth from 12 patients with Miller Class I MAGRs ≥ 2 mm on bilateral or contralateral sides. Patients were randomly assigned to receive coronally advanced flap (CAF) with either CTG (control) or L-PRF (test) treatment. Various parameters, including plaque and gingival index, clinical attachment level, recession depth, probing depth, recession width (RW), papilla width (PW), keratinized tissue width (KTW), gingival thickness (GT), percentage of RC, complete root coverage (CRC), and location of the relative gingival margin concerning the cemento-enamel junctions (GMCEJ) after CAF, were recorded at baseline, 3-, 6-, and 12-months post-surgery. On June 29, 2021 the study was registred to ClinicalTrials.gov (NCT04942821).

Results
Except KTW and GT gain, all clinical parameters, RC, and CRC were similar between the groups at all follow-up periods (p > 0.05). The higher GT and KTW gains were detected in the control group compared to test group at 12 months (p < 0.05). Both RC and CRC were positively associated with initial PW and GMCEJ, but negatively with initial RW (p < 0.05).

Conclusions
The current study concludes that L-PRF were equally effective as CTG in treating MAGRs in terms of RC and CRC. Additionally, RC and CRC outcomes appeared to be influenced by GMCEJ, PW, and RW.

Clinical relevance
L-PRF could represent a feasible substitute for CTG in treating MAGRs.
Prenatal maternal stress, breastfeeding and offspring ADHD symptoms
Authors: Jallow Jandeh , Hurtig Tuula , Kerkelä Martta , Miettunen Jouko , Halt Anu-Helmi 
Published: May 2024

AbstractThere is increasing evidence to suggest that environmental factors are associated with ADHD, but results regarding prenatal maternal stress, unwanted pregnancy, breastfeeding, and ADHD in children are controversial and few prospective studies have been conducted. Using prospectively collected data from the Northern Finland Birth Cohort 1986 (n = 7,910) we studied potential risk factors for ADHD symptoms at 8 and 16 years of age, including prenatal maternal stress and unwanted pregnancy, and protective factors including the duration of breastfeeding. Prenatal stress was associated with an increased risk of ADHD symptoms at the age of 16 (OR = 1.95, 95% CI: 1.34–2.80) and an unwanted pregnancy correlated with hyperactivity symptoms in the offspring at the age of 8 (OR = 2.08, 95% CI: 1.55–2.77). We did not find an association between prenatal maternal stress and hyperactivity symptoms in the offspring at the age of 8 (OR = 0.87, 95% CI: 0.69–1.08) or with unwanted pregnancy and ADHD symptoms at the age of 16 (OR = 1.13, 95% CI: 0.57–2.02). In relation to breastfeeding, over three months of exclusive breastfeeding was associated with lower hyperactivity symptoms in the 8-year follow-up (OR = 0.65, 95% CI: 0.46–0.92) and there was evidence of same kind of relationship concerning non-exclusive breastfeeding, but the association was not statistically significant (OR = 0.76, 95% CI: 0.54–1.06). In 16-year follow-up, under six months of non-exclusive breastfeeding showed an association with ADHD symptoms (OR = 0.68, 95% CI: 0.48–0.95) while exclusive breastfeeding did not (OR = 1.00, 95% CI: 0.66–1.55). In conclusion, our findings suggest that prenatal maternal stress increases the risk of more severe forms of ADHD symptoms in the offspring and breastfeeding can protect against such symptoms at the ages of 8 and 16.
Robotic transversus abdominis release (TAR) for ventral hernia repairs is associated with low surgical site occurrence rates and length of stay despite increasing modifiable comorbidities
Authors: Skoczek A. C. , Ruane P. W. , Holland A. B. , Hamilton J. K. , Fernandez D. L. 
Published: May 2024

Abstract
Purpose
Modifiable comorbidities (MCMs) have previously been shown to complicate postoperative wound healing occasionally leading to surgeon hesitancy to repair ventral hernias prior to preoperative optimization of comorbidities. This study describes the effects of MCMs on surgical site occurrences (SSOs) and hospital length of stay (LOS) following robotic transversus abdominis release (TAR) with poly-4-hydroxybutyrate (P4HB) resorbable biosynthetic mesh retromuscular sublay for ventral hernia repair in patients who had not undergone preoperative optimization.

Methods
A single-surgeon retrospective review was performed for patients who underwent the robotic TAR procedure with P4HB mesh between January 2015 and May 2022. Patients were stratified by the amount of MCMs present: 0, 1, or 2 + . MCMs included obesity, diabetes, and current tobacco use. Patient data was analyzed for the first 60 days following their operation. Primary outcomes included 60-day SSO rates and hospital LOS.

Results
Three hundred and thirty-four subjects met the inclusion criteria for SSO and prolonged LOS analysis. 16.8% had no MCM, 56.1% had 1 MCM, and 27% had 2 + MCMs. No significant difference in SSO was seen between the 3 groups; however, having 2 + MCMs was significantly associated with increased odds of SSO (odds ratio 3.25, P = .019). When the groups were broken down, only having a history of diabetes plus obesity was associated with significantly increased odds of SSO (odds ratio 3.54, P = .02). No group showed significantly increased odds of prolonged LOS.

Conclusion
2 + MCMs significantly increase the odds of SSO, specifically in patients who have a history of diabetes and obesity. However, the presence of any number of MCMs was not associated with increased odds of prolonged LOS.
Adjuvant and post-recurrent treatment patterns in patients with resectable gastric cancer in Japan: a retrospective database cohort study
Authors: Yoshikawa Takaki , Kikko Yorifumi , Makino Reina , Kimijima Yuya , Nishiyama Eiji , Matsuda Yuko , Casaes Teixeira Bruno , Tejada Mariella , Carroll Robert , Hironaka Shuichi 
Published: May 2024

Abstract
Background
This study examined temporal shifts in adjuvant therapy patterns in Japanese patients with resectable gastric cancer (GC) and treatment patterns of first-line and subsequent therapy among those with recurrent disease.

Methods
This retrospective analysis of hospital-based administrative claims data (April 1, 2008 to March 31, 2022) included adults (aged ≥ 20 years) with GC who started adjuvant therapy on or after October 1, 2008 (adjuvant cohort) and patients in the adjuvant cohort with disease recurrence (recurrent cohort), further defined by the time to recurrence (≤ 180 or > 180 days after adjuvant therapy).

Results
In the adjuvant cohort (n = 17,062), the most common regimen during October 2008–May 2016 was tegafur/gimeracil/oteracil potassium (S-1; 95.7%). As new standard adjuvant regimen options were established, adjuvant S-1 use decreased to 65.0% and fluoropyrimidine plus oxaliplatin or docetaxel plus S-1 use increased to 15.0% and 20.0%, respectively, in September 2019–March 2022. In the recurrent cohort with no history of trastuzumab/trastuzumab deruxtecan treatment (n = 1257), the most common first-line regimens were paclitaxel plus ramucirumab (34.0%), capecitabine plus oxaliplatin (CapeOX; 17.0%), and nab-paclitaxel plus ramucirumab (10.1%) in patients with early recurrence, and S-1 plus oxaliplatin (26.3%), S-1 plus cisplatin (15.3%), CapeOX (14.0%), S-1 (13.2%), and paclitaxel plus ramucirumab (10.8%) in those with late recurrence.

Conclusions
This study demonstrated temporal shifts in adjuvant treatment patterns that followed the establishment of novel regimens, and confirmed that post-recurrent treatment patterns were consistent with the Japanese Gastric Cancer Association guideline recommendations.
The intergenerational learning effects of a home study program for elementary and junior high school children on knowledge and awareness of plastic consumption
Authors: Kalyanasundaram Maheshwari , Ando Yuta , Asari Misuzu 
Published: May 2024

AbstractEducation through intergenerational learning (IGL) can be a key to consumer behavior change to combat plastic issues. The objectives of this study are to create a home study program that fosters IGL, targeting elementary and junior high school children of Kyoto city, understand if the program can increase student’s personalization of plastics issues, and understand if IGL can play a role in enabling plastic reduction actions in the household. A program, in which the 25 participating children proposed, executed, and monitored 3 actions to reduce plastic consumption, including their family, was successfully developed. To analyze the changes, children’s pre- and post-questionnaires and parents post-questionnaire were distributed. By experiencing the program, children felt increased guilt toward plastic use. Qualitative analysis revealed the barriers (lack of options, habits, lack of information) felt by the children when trying to reduce plastic. Feelings of guilt and facing barriers are parts of personalization and indicate that the program had initiated personalization process. In terms of IGL, qualitative analysis revealed that families that had social issues-based conversations during the program, and children who themselves decided reduction actions, engaged in plastic reduction better. Hence, education centering around IGL with effective personalization can influence household behavior.
Can Machine Learning Explain Alpha Generated by ESG Factors?
Authors: Carlei Vittorio , Cascioli Piera , Ceccarelli Alessandro , Furia Donatella 
Published: May 2024

AbstractThis research explores the use of machine learning to predict alpha in constructing portfolios, leveraging a broad array of environmental, social, and governance (ESG) factors within the S&P 500 index. Existing literature bases analyses on synthetic indicators, this work proposes an analytical deep dive based on a dataset containing the sub-indicators that give rise to the aforementioned synthetic indices. Since such dimensionality of variables requires specific processing, we deemed it necessary to use a machine learning algorithm, allowing us to study, with strong specificity, two types of relationships: the interaction between individual ESG variables and their effect on corporate performance.The results clearly show that ESG factors have a significant relationship with company performance. These findings emphasise the importance of integrating ESG indicators into quantitative investment strategies using Machine Learning methodologies.
Comparison of different hulled wheat genotypes in terms of yield, morphological, and nutritional properties
Authors: Temizgul Ridvan , Ciftci Beyza , Kardes Yusuf Murat , Kara Rukiye , Temizgul Sumeyye , Yilmaz Semih , Kaplan Mahmut 
Published: May 2024

Abstract
This study is conducted to characterize the yield and some of hulled wheat’s morphological and nutritional attributes. For this purpose, a total of 88 local hulled wheat samples were collected, including 7 T. dicoccum, 28 T. monococcum, 7 T. speldoides, 23 T. boeoticum, 3 T. araraticum, 4 Triticum sp, 2 T. urartu and 14 T. turgidum genotype was used as plant material. The field experiment was conducted for two years, from 2017 to 2018 and 2018 to 2019. The findings showed that grain yield varied between 40.75–398.75 g/m2, biological yield 86.90–1166.33 g/m2, harvest index 18.15–53.96%, spike length 1.2–8.1 cm, plant height 29.8–82.8 cm and length of upper internode 18.4–53 cm. The auricle color of the genotypes was white, and no hairiness or waxiness was observed. Most of the genotypes have developed erect. Crude ash contents of the hulled wheat vary between 1.7 and 5.10%, crude protein 10.12-19.48%, dietary fiber 2.2-8.2%, total starch 49.50–67.98%, resistant starch 0.25–3.38%, non-resistant starch 48.08–64.95%, amylose 3.43–42.88%, amylopectin 57.13–96.58%. Hulled wheat species and genotypes showed significant differences in yield and nutritional properties. Many genotypes used in the study have the potential to be cultured in field agriculture and contribute to the production of nutritional products in the future with their superior characteristics. In addition to testing genotypes in different climate and soil conditions, conducting research on the production of different foods is recommended.
Confidence and Outcome Expectations in Bilateral Negotiations–A Dynamic Model
Authors: Vetschera Rudolf , Dias Luis C. 
Published: May 2024

AbstractThis work proposes and studies a dynamic model of two bargaining parties exchanging offers over time, considering their confidence about the share of the “pie” they obtain, which translates into expectations regarding the outcome of the bargaining process. The model predicts the sequence of offers as well as the final agreement for given confidence parameters. A mathematical analysis of the model shows the outcome is an Asymmetric Nash Bargaining Solution with exponents determined by the bargainers’ confidence. Moreover, a compensation effect can be found between confidence and risk aversion. This work also considers that confidence levels of bargainers might change during the negotiation, and we conduct a comprehensive simulation study to analyze the effect of such changes. Through Monte-Carlo simulation, we show that a bargainer is better off if its confidence increases, but the advantage is lost if the other party’s confidence increases in a similar way. In that case, concessions are smaller and negotiations last longer. Changing confidence parameters make the outcome harder to predict, as it will depend more on the final confidence than the initial one. The simulations also show that the average size of concessions, and therefore the final agreement, depend not only on whether confidence increases or decreases, but also on the change rate, with stronger effects observed when change accelerates towards the end of the process.
The impact of ATP-sensitive potassium channel modulation on mitochondria in a Parkinson’s disease model using SH-SY5Y cells depends on their differentiation state
Authors: Evinova A , Baranovicova E , Hajduchova D , Dibdiakova K , Baranova I , Racay P , Strnadel J , Pecova R , Halasova E , Pokusa M 
Published: May 2024

AbstractInward rectifying potassium channels sensitive to ATP levels (KATP) have been the subject of investigation for several decades. Modulators of KATP channels are well-established treatments for metabolic as well as cardiovascular diseases. Experimental studies have also shown the potential of KATP modulation in neurodegenerative disorders. However, to date, data regarding the effects of KATP antagonists/agonists in experiments related to neurodegeneration remain inconsistent. The main source of confusion in evaluating available data seems to be the choice of experimental models. The present study aims to provide a comprehensive understanding of the effects of both opening and blocking KATP channels in two forms of SH-SY5Y cells. Our results offer valuable insights into the significance of metabolic differences between differentiated and non-differentiated SH-SY5Y cells, particularly in the context of glibenclamide and diazoxide effects under normal conditions and during the initiation of pathological events simulating Parkinson’s disease in vitro. We emphasize the analysis of mitochondrial functions and changes in mitochondrial network morphology. The heightened protein expression of KATP channels identified in non-differentiated SH-SY5Y cells seems to be a platform for a more significant impact of KATP modulators in this cell type. The efficiency of rotenone treatment in inducing morphological changes in the mitochondrial network depends on the differentiation status of SH-SY5Y cells.