bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of uterine artery embolization on ovarian function and pregnancy outcome after uterine-fibroids treatment: A prospective study
Authors: Liu Jing-Lei , Liang Zhi-Hui , Cui Bao , Liu Jian-Yu , Sun Li 
Published: May 2024

BACKGROUND
Uterine fibroids are benign tumors that originate from smooth muscle cells of the uterus. It is the most common gynecological disorder, affecting up to 80% of women of reproductive age. Uterine fibroids can cause various symptoms such as abnormal uterine bleeding, pelvic pain, infertility, and pregnancy complications. The treatment options for uterine fibroids include medical therapy, surgical intervention, and minimally invasive techniques.
AIM
To compare ovarian function of women with uterine fibroids who did or did not undergo uterine artery embolization (UAE).
METHODS
This prospective cohort study enrolled 87 women with symptomatic uterine fibroids who underwent UAE, and 87 women with the same symptoms who did not undergo UAE but received conservative management or other treatments. The two groups were matched for age, body mass index, parity, and baseline characteristics of uterine fibroids. The primary outcome was ovarian function that was evaluated by serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and anti-Müllerian hormone (AMH), as well as ovarian reserve tests, such as antral follicle count (AFC) and ovarian volume (OV). The secondary outcome was fertility that was evaluated based on the menstrual cycle, ovulation, conception, pregnancy, and delivery. The participants were followed-up for 36 months and assessed at 1, 3, 6, 12, 24, and 36 months after treatment.
RESULTS
The study found that the most common minor complication of UAE was postembolization syndrome in 73.6% of women, resolving within a week. No significant differences were observed between the UAE group and the control group in serum levels of reproductive hormones (FSH, LH, E2, AMH) and ovarian reserve indicators (AFC, OV) at any point up to 36 months post-treatment. Additionally, there were no significant differences in conception, pregnancy, or delivery rates, with the average time to conception and gestational age at delivery being similar between the two groups. Birth weights were also comparable. Finally, there was no significant correlation between ovarian function, fertility indicators, and the type or amount of embolic agent used or the change in fibroids post-treatment.
CONCLUSION
UAE resulted in significantly positive pregnancy outcomes, no adverse events post-treatment, and is a safe and effective treatment for uterine fibroids that preserves ovarian function and fertility.
Role of savolitinib in advanced gastric adenocarcinoma with meningeal carcinomatosis and cerebellar metastasis: A case report
Authors: Weng Zhi-Yun , Huang Wen-Ye , Shi Bin-Kan , Pan Jian-Jia 
Published: May 2024

BACKGROUND
Brain metastases (BM) are very rare in gastric adenocarcinoma (GaC), and patients with BMs have a higher mortality rate due to stronger tumor aggressiveness. However, its pathogenesis remains unclear. Genetic testing revealed cellular-mesenchymal epithelial transition factor receptor (MET) amplification. Therefore, treatment with savolitinib, a small molecule inhibitor of c-Met, was selected.
CASE SUMMARY
A 66-year-old woman was diagnosed with advanced GaC 6 months prior to presentation due to back pain. Cerebellar and meningeal metastases were observed during candonilimab combined with oxaliplatin and capecitabine therapy. The patient experienced frequent generalized seizures and persistent drowsiness in the emergency department. Genetic testing of cerebrospinal fluid and peripheral blood revealed increased MET amplification. After discussing treatment options with the patient, savolitinib tablets were administered. After a month of treatment, the intracranial lesions shrank considerably.
CONCLUSION
BM is very rare in advanced GaC, especially in meningeal cancer, that is characterized by rapid disease deterioration. There are very few effective treatment options available; however, technological breakthroughs in genomics have provided a basis for personalized treatment. Furthermore, MET amplification may be a key driver of BM in gastric cancer; however, this conclusion requires further investigation.
Tuberous sclerosis complex combined with primary lymphedema: A case report
Authors: Li Xing-Peng , Sun Xiao-Li , Liu Xin , Wen Zhe , Jiang Li-Hua , Fu Yan , Yue Yun-Long , Wang Ren-Gui 
Published: May 2024

BACKGROUND
Tuberous sclerosis complex (TSC) and primary lymphedema (PLE) are both rare diseases, and it is even rarer for both to occur in the same patient. In this work, we have provided a detailed description of a patient's clinical presentation, imaging findings, and treatment. And a retrospective analysis was conducted on 14 published relevant case reports.
CASE SUMMARY
A 16-year-old male came to our hospital for treatment due to right lower limb swelling. This swelling is already present from birth. The patient’s memory had been progressively declining. Seizures had occurred 1 year prior at an unknown frequency. The patient was diagnosed with TSC combined with PLE through multimodal imaging examination: Computed tomography, magnetic resonance imaging, and lymphoscintigraphy. The patient underwent liposuction. The swelling of the patient's right lower limb significantly improved after surgery. Epilepsy did not occur.after taking antiepileptic drugs and sirolimus.
CONCLUSION
TSC with PLE is a rare and systemic disease. Imaging can detect lesions of this disease, which are important for diagnosis and treatment.
Photon-enhanced thermionic emission solar cells based on boron-doped graphene/carbon nanosphere composite aerogel photocathode material
Authors: Luo Shenghao , Liao Songchi , Wang Chengfeng , Fu Yuechun , He Huan , Shen Xiaoming 
Published: May 2024

This study employed a two-step hydrothermal reduction process and freeze-drying technique. Initially, carbon nanosphere composite aerogels (CNSs) were synthesized through the hydrothermal reduction of glucose. Subsequently, boron-doped graphene/carbon nanosphere composite aerogel (BGA/CNS) was prepared by utilizing graphene oxide (GO) and boric acid as carbon (C) and boron (B) sources, respectively, in conjunction with CNS. The photo-enhanced thermionic electron emission (PETE) performance of the samples was assessed using a custom-made device. Boron atom doping was found to modulate the bandgap of graphene aerogel and induce P-type semiconductor characteristics, while the addition of CNSs increased its specific surface area, thereby enhancing its photoelectric properties. The results indicated that BGA/CNS-8h exhibited superior PETE effects, with a short-circuit current, open-circuit voltage, and maximum power of 5.81 µA, −2.10V, and −1.57µW.
DSP-based inter-channel interference monitoring in flexible wavelength-routed networks
Authors: Minelli Leonardo , Bosco Gabriella , Straullu Stefano , Nespola Antonino , Piciaccia Stefano , Pilori Dario 
Published: May 2024

The efficiency of optical networks employing flexible wavelength division multiplexing (WDM) can be increased by maximizing the throughput of each individual channel, provided that the position of its neighboring channel is known with sufficient accuracy in order to avoid inter-channel interference. In this paper, we propose a digital signal processing (DSP) algorithm, leveraging the use of an artificial neural network (ANN), to estimate the neighboring channels’ distance by processing raw digital samples from a standard coherent receiver. We present an efficient dataset design approach, based on Latin hypercube sampling (LHS), in order to effectively optimize and validate the algorithm under different assumptions on the optical WDM channels. We investigate the accuracy of the ANN-based DSP scheme through simulation analysis, highlighting its potential in relation to the characteristics of the optical network. Finally, we validate our approach in an experimental setup using standard commercial coherent transceivers. The experimental results show that the distance from the neighboring WDM channels can be estimated with a root mean square error of less than 1.5 GHz for a channel under test with a symbol rate of 52 GBaud.
Global, regional, and national burden of heatwave-related mortality from 1990 to 2019: A three-stage modelling study
Authors: Zhao Qi , Li Shanshan , Ye Tingting , Wu Yao , Gasparrini Antonio , Tong Shilu , Urban Aleš , Vicedo-Cabrera Ana Maria , Tobias Aurelio , Armstrong Ben , Royé Dominic , Lavigne Eric , de’Donato Francesca , Sera Francesco , Kan Haidong , Schwartz Joel , Pascal Mathilde , Ryti Niilo , Goodman Patrick , Saldiva Paulo Hilario Nascimento , Bell Michelle L. , Guo Yuming ,   on behalf of the MCC Collaborative Research Network
Published: May 2024

Background
The regional disparity of heatwave-related mortality over a long period has not been sufficiently assessed across the globe, impeding the localisation of adaptation planning and risk management towards climate change. We quantified the global mortality burden associated with heatwaves at a spatial resolution of 0.5°×0.5° and the temporal change from 1990 to 2019.

Methods and findings
We collected data on daily deaths and temperature from 750 locations of 43 countries or regions, and 5 meta-predictors in 0.5°×0.5° resolution across the world. Heatwaves were defined as location-specific daily mean temperature ≥95th percentiles of year-round temperature range with duration ≥2 days. We first estimated the location-specific heatwave-mortality association. Secondly, a multivariate meta-regression was fitted between location-specific associations and 5 meta-predictors, which was in the third stage used with grid cell-specific meta-predictors to predict grid cell-specific association. Heatwave-related excess deaths were calculated for each grid and aggregated. During 1990 to 2019, 0.94% (95% CI: 0.68–1.19) of deaths [i.e., 153,078 cases (95% eCI: 109,950–194,227)] per warm season were estimated to be from heatwaves, accounting for 236 (95% eCI: 170–300) deaths per 10 million residents. The ratio between heatwave-related excess deaths and all premature deaths per warm season remained relatively unchanged over the 30 years, while the number of heatwave-related excess deaths per 10 million residents per warm season declined by 7.2% per decade in comparison to the 30-year average. Locations with the highest heatwave-related death ratio and rate were in Southern and Eastern Europe or areas had polar and alpine climates, and/or their residents had high incomes. The temporal change of heatwave-related mortality burden showed geographic disparities, such that locations with tropical climate or low incomes were observed with the greatest decline. The main limitation of this study was the lack of data from certain regions, e.g., Arabian Peninsula and South Asia.

Conclusions
Heatwaves were associated with substantial mortality burden that varied spatiotemporally over the globe in the past 30 years. The findings indicate the potential benefit of governmental actions to enhance health sector adaptation and resilience, accounting for inequalities across communities.
A regressive analysis of the main environmental risk factors of human echinococcosis in 370 counties in China
Authors: Wang Liying , Wang Zhiyi , Qin Min , Lei Jiaxi , Cheng Xixi , Yan Jun , Gavotte Laurent , Frutos Roger 
Published: May 2024

Background
Echinococcosis is a natural focal, highly prevalent disease in China. Factors influencing the spread of echinococcosis are not only related to personal exposure but also closely related to the environment itself. The purpose of this study was to explore the influence of environmental factors on the prevalence of human echinococcosis and to provide a reference for prevention and control of echinococcosis in the future.

Methods
Data were collected from 370 endemic counties in China in 2018. By downloading Modis, DEM and other remote-sensing images in 2018. Data on environmental factors, i.e., elevation, land surface temperature (LST) and normalized difference vegetation index (NDVI) were collected. Rank correlation analysis was conducted between each environmental factor and the prevalence of echinococcosis at the county level. Negative binomial regression was used to analyze the impact of environmental factors on the prevalence of human echinococcosis at the county level.

Results
According to rank correlation analysis, the prevalence of human echinococcosis in each county was positively correlated with elevation, negatively correlated with LST, and negatively correlated with NDVI in May, June and July. Negative binomial regression showed that the prevalence of human echinococcosis was negatively correlated with annual LST and summer NDVI, and positively correlated with average elevation and dog infection rate. The prevalence of human cystic echinococcosis was inversely correlated with the annual average LST, and positively correlated with both the average elevation and the prevalence rate of domestic animals. The prevalence of human alveolar echinococcosis was positively correlated with both NDVI in autumn and average elevation, and negatively correlated with NDVI in winter.

Conclusion
The prevalence of echinococcosis in the population is affected by environmental factors. Environmental risk assessment and prediction can be conducted in order to rationally allocate health resources and improve both prevention and control efficiency of echinococcosis.
Mental-somatic multimorbidity in trajectories of cognitive function for middle-aged and older adults
Authors: Chen Siting , Nagel Corey L. , Liu Ruotong , Botoseneanu Anda , Allore Heather G. , Newsom Jason T. , Thielke Stephen , Kaye Jeffrey , Quiñones Ana R. 
Published: May 2024

Introduction
Multimorbidity may confer higher risk for cognitive decline than any single constituent disease. This study aims to identify distinct trajectories of cognitive impairment probability among middle-aged and older adults, and to assess the effect of changes in mental-somatic multimorbidity on these distinct trajectories.

Methods
Data from the Health and Retirement Study (1998–2016) were employed to estimate group-based trajectory models identifying distinct trajectories of cognitive impairment probability. Four time-varying mental-somatic multimorbidity combinations (somatic, stroke, depressive, stroke and depressive) were examined for their association with observed trajectories of cognitive impairment probability with age. Multinomial logistic regression analysis was conducted to quantify the association of sociodemographic and health-related factors with trajectory group membership.

Results
Respondents (N = 20,070) had a mean age of 61.0 years (SD = 8.7) at baseline. Three distinct cognitive trajectories were identified using group-based trajectory modelling: (1) Low risk with late-life increase (62.6%), (2) Low initial risk with rapid increase (25.7%), and (3) High risk (11.7%). For adults following along Low risk with late-life increase, the odds of cognitive impairment for stroke and depressive multimorbidity (OR:3.92, 95%CI:2.91,5.28) were nearly two times higher than either stroke multimorbidity (OR:2.06, 95%CI:1.75,2.43) or depressive multimorbidity (OR:2.03, 95%CI:1.71,2.41). The odds of cognitive impairment for stroke and depressive multimorbidity in Low initial risk with rapid increase or High risk (OR:4.31, 95%CI:3.50,5.31; OR:3.43, 95%CI:2.07,5.66, respectively) were moderately higher than stroke multimorbidity (OR:2.71, 95%CI:2.35, 3.13; OR: 3.23, 95%CI:2.16, 4.81, respectively). In the multinomial logistic regression model, non-Hispanic Black and Hispanic respondents had higher odds of being in Low initial risk with rapid increase and High risk relative to non-Hispanic White adults.

Conclusions
These findings show that depressive and stroke multimorbidity combinations have the greatest association with rapid cognitive declines and their prevention may postpone these declines, especially in socially disadvantaged and minoritized groups.
Does Effective Policy Implementation Affect Municipal Solid Waste Management in Bandung?
Authors: Keita Sandi 
Published: May 2024

The continuous increase in generation and volume of solid waste in cities including Bandung could severely have a negative effect on health of the population and on the environment. This phenomenon is expected to continue as the population of Bandung keeps growing due to urbanization. However, the city government of Bandung formulated regional waste management regulation. while regional cleaning company PDK was tasked and subsidized by the city government to carry out the implementation of waste management regulation of the city. The implementation of the regulation and the management of waste is analyzed using descriptive and quantitative analysis methods. The results of the analysis shows that the regulations are not effectively implemented and the waste management is affected by lack of adequate infrastructure, human resource, public awareness and technology.
Evaluation of renal sodium handling in heart failure with preserved ejection fraction: A pilot study
Authors: Agarwal Adhish , Beddhu Srinivasan , Boucher Robert , Rao Veena , Ramkumar Nirupama , Rodan Aylin R. , Fang Jacob , Wynne Brandi M. , Drakos Stavros G. , Hanff Thomas , Cheung Alfred K. , Fang James C. 
Published: May 2024

AbstractThe pathophysiology behind sodium retention in heart failure with preserved ejection fraction (HFpEF) remains poorly understood. We hypothesized that patients with HFpEF have impaired natriuresis and diuresis in response to volume expansion and diuretic challenge, which is associated with renal hypo‐responsiveness to endogenous natriuretic peptides. Nine HFpEF patients and five controls received saline infusion (0.25 mL/kg/min for 60 min) followed by intravenous furosemide (20 mg or home dose) 2 h after the infusion. Blood and urine samples were collected at baseline, 2 h after saline infusion, and 2 h after furosemide administration; urinary volumes were recorded. The urinary cyclic guanosine monophosphate (ucGMP)/plasma B‐type NP (BNP) ratio was calculated as a measure of renal response to endogenous BNP. Wilcoxon rank‐sum test was used to compare the groups. Compared to controls, HFpEF patients had reduced urine output (2480 vs.3541 mL; p = 0.028), lower urinary sodium excretion over 2 h after saline infusion (the percentage of infused sodium excreted 12% vs. 47%; p = 0.003), and a lower baseline ucGMP/plasma BNP ratio (0.7 vs. 7.3 (pmol/mL)/(mg/dL)/(pg/mL); p = 0.014). Patients with HFpEF had impaired natriuretic response to intravenous saline and furosemide administration and lower baseline ucGMP/plasma BNP ratios indicating renal hypo‐responsiveness to NPs.
Using Bland-Altman plot-based harmonization algorithm to optimize the harmonization for immunoassays
Authors: Fang Huiling , Yang Ruifeng , Guo Jiayue , Ren Xinxin , Chang Xin , Kang Lan , Zhu Yuqing 
Published: May 2024

Abstract

Objectives
Harmonization has been recommended by the International Organization for Standard (ISO) to achieve equivalent results across in vitro diagnostic measurement devices (IVD-MDs). We aim to evaluate the effectiveness of Bland-Altman plot-based harmonization algorithm (BA-BHA) created in this study and compare it with weighted Deming regression-based harmonization algorithm (WD-BHA) proposed in ISO 21151:2020.

Methods
Eighty patient sera were used as the harmonization reference material (HRM) to develop IVD-MD-specific harmonization algorithms. Another panel of 40 patient sera was used to validate the effectiveness of harmonization algorithms. We compared regression slopes, intercepts, Bland-Altman plot layouts, percent differences, limits of agreement (LoAs), between-method coefficients of variation (CV) before and after harmonization.

Results
After harmonization by WD-BHA, acceptable slopes and intercepts between measured values and HRM targets were observed in weighted Deming regression, but not in Passing-Bablok analysis. Mean differences were −5.5 to 5.0 % and differences at specific levels were −33.9 to 23.9 %. LoAs were −64.6 to 74.6 %. Between-method CV was 22.9 % (±12.9 %). However, after harmonization by BA-BHA, both weighted Deming and Passing-Bablok regressions equations presented harmonized results. Mean differences were −0.3 to 0.2 % and differences at specific levels were −1.1 to 1.6 %. LoAs were −23.3 to 23.2 %. Between-method CV was 8.4 % (±4.0 %). The data points were evenly distributed at both sides of the mean in Bland-Altman plots.

Conclusions
The inequivalence of test results between different methods can be improved but unacceptable analytical differences at specific levels may be hidden in terms of an acceptable slope and intercept on WD-BHA. The new protocol BA-BHA may be a viable alternative to optimize the harmonization for immunoassays.
Assessment of anti-diabetic properties of Ziziphus oenopolia (L.) wild edible fruit extract: In vitro and in silico investigations through molecular docking analysis
Authors: Vadivu R. Shunmuga , Bakthavatchalam Senthil , Rani Vasthi Gnana , Hirad Abdurahman Hajinur , Wen Zhi-Hong , Yuan Chien-Han , Vinayagam Ramachandran 
Published: May 2024

Abstract
Globally, healthcare is concerned about the rising prevalence of type 2 diabetes. Phytochemicals from medicinal plants have shown great promise in improving human health. The present study aimed to determine the secondary metabolites of Ziziphus oenopolia (L.) fruit extract that contribute to its anti-diabetic activity. The anti-diabetic properties were assessed by in vitro and in silico approaches using α-amylase and α-glucosidase inhibitory assays. Gas chromatography and mass spectroscopy analyses were used to profile Z. oenopolia fruit contents, and a total of four bioactive chemicals and eight phytocompounds were tentatively identified, including flavonoids, terpenoids, phenols, steroids, tannins, and saponins. The Z. oenopolia fruit hydroalcoholic extract inhibits α-amylase and α-glucosidase enzymes in a dose-dependent manner (IC50 = 328.76 and 337.28 µg/mL, R
2 = 0.979 and 0.981). Additionally, phytochemicals found in Z. oenopolia fruit exhibit the ability to inhibit anti-diabetic targets, specifically α-amylase and α-glucosidase (2QV4 vs 3A4A; correlation coefficient, r = 0.955), as demonstrated by computational analysis. This establishes the fruit as a promising and environmentally friendly option for treating hyperglycemia, highlighting the positive correlation between anti-diabetic objectives.
On a generalization of the Opial inequality
Authors: Bosch Paul , Portilla Ana , Rodriguez Jose M. , Sigarreta Jose M. 
Published: May 2024

Abstract
Inequalities are essential in pure and applied mathematics. In particular, Opial’s inequality and its generalizations have been playing an important role in the study of the existence and uniqueness of initial and boundary value problems. In this work, some new Opial-type inequalities are given and applied to generalized Riemann-Liouville-type integral operators.
On Periodic solutions for implicit nonlinear Caputo tempered fractional differential problems
Authors: Bouriah Soufyane , Salim Abdelkrim , Benchohra Mouffak , Karapinar Erdal 
Published: May 2024

Abstract
The main goal of this article is to study the existence and uniqueness of periodic solutions for the implicit problem with nonlinear fractional differential equation involving the Caputo tempered fractional derivative. The proofs are based upon the coincidence degree theory of Mawhin. To show the efficiency of the stated result, two illustrative examples will be demonstrated.