bluuebunny/crossref_metadata_2025_split huggingface dataset:
Construct validity and reliability of a French–Canadian translation of the eating in the absence of hunger questionnaire for children and adolescents
Authors: Savard C. , Bégin S. , Robitaille J. , Hivert M.-F. , Parent S. , Gingras V. 
Published: May 2024

Eating in the absence of hunger (EAH) has been associated with overweight and obesity during childhood. The gold standard to assess this behavior is a laboratory-based protocol, but a questionnaire to assess EAH more efficiently in children and adolescents has been developed and validated in English. We assessed construct validity (structural and convergent validity) and reliability (internal consistency and temporal stability) of a French translation of the EAH Questionnaire for Children and Adolescents among French–Canadian youths. We recruited participants in Montreal (Canada) aged 7–15 years old, who completed the questionnaire and provided anthropometric data. We asked participants to complete the questionnaire a second time ∼4 weeks later. The questionnaire consists of 14 questions and 3 subscales that assess EAH due to negative affect, fatigue/boredom, and external cues. We performed an exploratory factor analysis to test the factor structure and we calculated Cronbach alpha coefficients and intra-class correlations to assess internal consistency and temporal stability, respectively. We assessed associations between EAH and BMI z-score using Pearson correlations. We included 196 participants (50% girls; mean (SD) 11.9 (2.3) years old) for the first completion and 153 for the second completion. The exploratory factor analysis generated the same three subscales as the original questionnaire: negative affect (α = 0.86; ICC = 0.78), fatigue/boredom (α = 0.75; ICC = 0.70), and external cues (α = 0.68; ICC = 0.54). Participant’s BMI z-scores were positively associated with the average scores from the negative affect subscale ( r = 0.19; ρ = 0.009). Our results suggest that this questionnaire has an adequate construct validity, internal consistency, and temporal stability.
Short- vs. long-distance physics in $$B\rightarrow K^{(*)} \ell ^+\ell ^-$$: a data-driven analysis
Authors: Bordone Marzia , Isidori Gino , Mächler Sandro , Tinari Arianna 
Published: May 2024

AbstractWe analyze data on $$B\rightarrow K\mu ^+\mu ^-$$

B
→
K

μ
+

μ
-

and $$B\rightarrow K^*\mu ^+\mu ^-$$

B
→

K
∗

μ
+

μ
-

decays in the whole dilepton invariant mass spectrum with the aim of disentangling short- vs. long-distance contributions. The sizable long-distance amplitudes from $$c \overline{c}$$

c

c
¯

narrow resonances are taken into account by employing a dispersive approach. For each available $$q^2=m^2_{\mu \mu }$$

q
2

=

m

μ
μ

2

bin and each helicity amplitude an independent determination of the Wilson coefficient $$C_9$$

C
9

, describing $$b\rightarrow s\ell ^+\ell ^-$$

b
→
s

ℓ
+

ℓ
-

transitions at short distances, is obtained. The consistency of the $$C_9$$

C
9

values thus obtained provides an a posteriori check of the absence of additional, sizable, long-distance contributions. The systematic difference of these values from the Standard Model expectation supports the hypothesis of a non-standard $$b\rightarrow s \mu ^+\mu ^-$$

b
→
s

μ
+

μ
-

amplitude of short-distance origin.
The origin of the 95 GeV excess in the flavor-dependent $$U(1)_X$$ model
Authors: Ge Zhao-feng , Niu Feng-Yan , Yang Jin-Lei 
Published: May 2024

AbstractThis study investigates the excesses observed in the CMS diphoton and ditau data around$$95~{\textrm{GeV}}$$95GeVwithin the framework of the flavor-dependent$$U(1)_X$$U(1)Xmodel. The model introduces a singlet scalar to explain the nonzero neutrino masses. This newly introduced Higgs interacts directly with the quark sector, motivated by the aim to explain the flavor numbers of the fermion sector. Additionally, it undergoes mixing with the SM-like Higgs boson. The study suggests that designating this singlet Higgs state in this model as the lightest Higgs boson holds great potential for explaining the excesses around$$95~{\textrm{GeV}}.$$95GeV.In the calculations, we maintained the masses of the lightest and next-to-lightest Higgs bosons at around$$95~{\textrm{GeV}}$$95GeVand$$125~{\textrm{GeV}}$$125GeVrespectively. It was found that the theoretical predictions on the signal strengthes$$\mu (h_{95})_{\gamma \gamma },$$μ(h95)γγ,$$\mu (h_{95})_{\tau \tau }$$μ(h95)ττin the flavor-dependent$$U(1)_X$$U(1)Xmodel can be fitted well to the excesses observed at CMS.
AN EXPERIMENTAL RIGHT ATRIUM PLATFORM TO ASSESS RECIRCULATION IN HEMODIALYSIS CATHETERS
Authors: E. D. HEATON CHARLES , ESPINO D. M. 
Published: May 2024

Hemodialysis (HD) is a treatment supporting decreased kidney function, via a catheter inserted into the heart’s Right Atrium (RA). Recirculation is a source of inefficiency for treatment, where blood is dialyzed again due to poor catheter design. Lab-testing is still relatively unexplored, hence, a mechanical testing system was designed with the intention of providing a consistent and repeatable environment for testing HD catheters. System geometry was composed using a Computer-Aided Design (CAD) model of a heart, with the RA scaled to appropriate dimensions, and a PolyDiMethylSiloxane (PDMS) model produced through 3D printing and negative wax casting. Pulsatile blood flow was mimicked by peristaltic pumps driving a blood analogue (BA). Recirculation was induced by adding dyed BA to the system via the catheter and measured using a colorimeter. The developed platform was initially evaluated using two catheters, demonstrating the capability to accurately replicate atrial hemodynamic conditions. Two step-tipped catheters, A and B, were tested at 350 ml/min, producing recirculation values of 13.11% and 18.58%, respectively. The results exhibit the ability of the system developed to evaluate HD catheter performance, with the potential to explore a wider range of tip geometries relevant to clinical preference. Furthermore, this advancement towards an anatomically accurate lab-based test system could be paired with computational methods to progress the evaluation of such medical devices and enhance their development.
Impact of scFv on Functionality and Safety of Third-Generation CD123 CAR T Cells
Authors: Fredon Maxime , Poussard Margaux , Biichlé Sabeha , Bonnefoy Francis , Mantion Charles-Frédéric , Seffar Evan , Renosi Florian , Bôle-Richard Elodie , Boidot Romain , Chevrier Sandrine , Anna François , Loustau Maria , Caumartin Julien , Gonçalves-Venturelli Mathieu , Robinet Eric , Saas Philippe , Deconinck Eric , Daguidau Etienne , Roussel Xavier , Godet Yann , Adotévi Olivier , Angelot-Delettre Fanny , Galaine Jeanne , Garnache-Ottou Francine 
Published: May 2024

Abstract
Chimeric antigen receptor (CAR) T cells express an extracellular domain consisting of a single-chain fragment variable (scFv) targeting a surface tumor-associated antigen. scFv selection should involve safety profiling with evaluation of the efficacy/toxicity balance, especially when the target antigen also is expressed on healthy cells. Here, to assess differences in terms of efficacy and on-target/off-tumor effects, we generated five different CARs targeting CD123 by substituting only the scFv. In in vitro models, T cells engineered to express three of these five CD123 CARs were effectively cytotoxic on leukemic cells without increasing lysis of monocytes or endothelial cells. Using the IncuCyte system, we confirmed the low cytotoxicity of CD123 CAR T cells on endothelial cells. Hematotoxicity evaluation using progenitor culture and CD34 cell lysis showed that two of the five CD123 CAR T cells were less cytotoxic on hematopoietic stem cells. Using a humanized mouse model, we confirmed that CD123− cells were not eliminated by the CD123 CAR T cells. Two CD123 CAR T cells reduced tumor infiltration and increased the overall survival of mice in three in vivo models of blastic plasmacytoid dendritic cell neoplasm. In an aggressive version of this model, bulk RNA sequencing analysis showed that these CD123 CAR T cells upregulated genes associated with cytotoxicity and activation/exhaustion a few days after the injection. Together, these results emphasize the importance of screening different scFvs for the development of CAR constructs to support selection of cells with the optimal risk–benefit ratio for clinical development.
Impact of Significant Hemoglobin Drop Without Bleeding in Patients Undergoing Transcatheter Aortic Valve Replacement
Authors: Reddy Pavan , Merdler Ilan , Zhang Cheng , Cellamare Matteo , Ben‐Dor Itsik , Satler Lowell F. , Rogers Toby , Garcia‐Garcia Hector M. , Waksman Ron 
Published: May 2024

Background
Hemoglobin (Hgb) drop without bleeding is common among patients undergoing transcatheter aortic valve replacement; however, the clinical implications of significant Hgb drop have not been fully evaluated.

Methods and Results

Consecutive patients undergoing transcatheter aortic valve replacement at our institution from 2011 to 2021 were retrospectively reviewed. Three groups were assessed: no Hgb drop and no bleed (NoD‐NoB [reference group]), Hgb drop with bleed, and Hgb drop and no bleed (D‐NoB). Hgb drop was defined as ≥3 g/dL decrease from pre‐ to post‐transcatheter aortic valve replacement. Outcomes of interest were in‐hospital death and 1‐year all‐cause mortality. A total of 1851 cases with complete Hgb data were included: NoD‐NoB: n=1579 (85.3%); D‐NoB: n=49 (2.6%); Hgb drop with bleed: n=223 (12.6%). Compared with NoD‐NoB, the D‐NoB group was older (81.1 versus 78.9 years of age) with higher preprocedure Hgb (12.9 versus 11.7 g/dL). In‐hospital death rate was higher among patients with D‐NoB versus NoD‐NoB (4.5% versus 0.8%,
P
<0.001) and similar to Hgb drop with bleed (4.5% versus 4.1%,
P
=0.999). Predictors of in‐hospital death were D‐NoB (odds ratio [OR], 3.45 [95% CI, 1.32–8.69]) and transfusion (OR, 10.6 [95% CI, 4.25–28.2]). Landmark survival analysis found that D‐NoB experienced 1‐year mortality rate comparable to NoD‐NoB, whereas Hgb drop with bleed had higher midterm mortality (hazard ratio [HR], 3.2 [95% CI, 1.83–5.73]), and transfusion continued to impact mortality (HR, 2.5 [95% CI, 1.79–3.63]).

Conclusions
Hgb drop without bleeding is common among patients undergoing transcatheter aortic valve replacement and may represent a higher risk of periprocedural death. Blood transfusion increases short‐ and midterm mortality risk in patients with and without bleeding, supporting a restrictive transfusion strategy.
Diabetes‐Related Macrovascular Complications Are Associated With an Increased Risk of Diabetic Microvascular Complications: A Prospective Study of 1518 Patients With Type 1 Diabetes and 20 802 Patients With Type 2 Diabetes in the UK Biobank
Authors: Zhang Xinyu , Zhao Shuzhi , Huang Yikeng , Ma Mingming , Li Bo , Li Chenxin , Zhu Xinyu , Xu Xun , Chen Haibin , Zhang Yili , Zhou Chuandi , Zheng Zhi 
Published: May 2024

Background
Diabetic vascular complications share common pathophysiological mechanisms, but the relationship between diabetes‐related macrovascular complications (MacroVCs) and incident diabetic microvascular complications remains unclear. We aimed to investigate the impact of MacroVCs on the risk of microvascular complications.

Methods and Results
There were 1518 participants with type 1 diabetes (T1D) and 20 802 participants with type 2 diabetes from the UK Biobank included in this longitudinal cohort study. MacroVCs were defined by the presence of macrovascular diseases diagnosed after diabetes at recruitment, including coronary heart disease, peripheral artery disease, stroke, and ≥2 MacroVCs. The primary outcome was incident microvascular complications, a composite of diabetic retinopathy, diabetic kidney disease, and diabetic neuropathy. During a median (interquartile range) follow‐up of 11.61 (5.84–13.12) years and 12.2 (9.50–13.18) years, 596 (39.3%) and 4113 (19.8%) participants developed a primary outcome in T1D and type 2 diabetes, respectively. After full adjustment for conventional risk factors, Cox regression models showed significant associations between individual as well as cumulative MacroVCs and the primary outcome, except for coronary heart disease in T1D (T1D: diabetes coronary heart disease: 1.25 [0.98–1.60]; diabetes peripheral artery disease: 3.00 [1.86–4.84]; diabetes stroke: 1.71 [1.08–2.72]; ≥2: 2.57 [1.66–3.99]; type 2 diabetes: diabetes coronary heart disease: 1.59 [1.38–1.82]; diabetes peripheral artery disease: 1.60 [1.01–2.54]; diabetes stroke: 1.50 [1.13–1.99]; ≥2: 2.66 [1.92–3.68]). Subgroup analysis showed that strict glycemic (glycated hemoglobin <6.5%) and blood pressure (<140/90 mm Hg) control attenuated the association.

Conclusions
Individual and cumulative MacroVCs confer significant risk of incident microvascular complications in patients with T1D and type 2 diabetes. Our results may facilitate cost‐effective high‐risk population identification and development of precise prevention strategies.
Outcomes Following Percutaneous Coronary Intervention in Patients With Multivessel Disease Who Were Recommended for But Declined Coronary Artery Bypass Graft Surgery
Authors: Koshy Anoop N. , Stone Gregg W. , Sartori Samantha , Dhulipala Vishal , Giustino Gennaro , Spirito Alessandro , Farhan Serdar , Smith Kenneth F. , Feng Yihan , Vinayak Manish , Salehi Negar , Tanner Richard , Hooda Amit , Krishnamoorthy Parasuram , Sweeny Joseph M. , Khera Sahil , Dangas George , Filsoufi Farzan , Mehran Roxana , Kini Annapoorna S. , Fuster Valentin , Sharma Samin K. 
Published: May 2024

Background
Patients may prefer percutaneous coronary intervention (PCI) over coronary artery bypass graft (CABG) surgery, despite heart team recommendations. The outcomes in such patients have not been examined. We sought to examine the results of PCI in patients who were recommended for but declined CABG.

Methods and Results

Consecutive patients with stable ischemic heart disease and unprotected left main or 3‐vessel disease or Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery score >22 who underwent PCI after heart team review between 2013 and 2020 were included. Patients were categorized into 3 groups according to heart team recommendations on the basis of appropriate use criteria: (1) PCI‐recommended; (2) CABG‐eligible but refused CABG (CABG‐refusal); and (3) CABG‐ineligible. The primary end point was the composite of death, myocardial infarction, or stroke at 1 year. The study included 3687 patients undergoing PCI (PCI‐recommended, n=1718 [46.6%]), CABG‐refusal (n=1595 [43.3%]), and CABG‐ineligible (n=374 [10.1%]). Clinical and procedural risk increased across the 3 groups, with the highest comorbidity burden in CABG‐ineligible patients. Composite events within 1 year after PCI occurred in 55 (4.1%), 91 (7.0%), and 41 (14.8%) of patients in the PCI‐recommended, CABG‐refusal, and CABG‐ineligible groups, respectively. After multivariable adjustment, the risk of the primary composite outcome was significantly higher in the CABG‐refusal (hazard ratio [HR], 1.67 [95% CI, 1.08–3.56];
P
=0.02) and CABG‐ineligible patients (HR, 3.26 [95% CI, 1.28–3.65];
P
=0.004) groups compared with the reference PCI‐recommended group, driven by increased death and stroke.

Conclusions
Cardiovascular event rates after PCI were significantly higher in patients with multivessel disease who declined or were ineligible for CABG. Our findings provide real‐world data to inform shared decision‐making discussions.
Prior Context and Individual Alpha Frequency Influence Predictive Processing during Language Comprehension
Authors: Jano Sophie , Cross Zachariah R. , Chatburn Alex , Schlesewsky Matthias , Bornkessel-Schlesewsky Ina 
Published: May 2024

Abstract
The extent to which the brain predicts upcoming information during language processing remains controversial. To shed light on this debate, the present study reanalyzed Nieuwland and colleagues' (2018) [Nieuwland, M. S., Politzer-Ahles, S., Heyselaar, E., Segaert, K., Darley, E., Kazanina, N., et al. Large-scale replication study reveals a limit on probabilistic prediction in language comprehension. eLife, 7, e33468, 2018] replication of DeLong and colleagues (2015) [DeLong, K. A., Urbach, T. P., & Kutas, M. Probabilistic word pre-activation during language comprehension inferred from electrical brain activity. Nature Neuroscience, 8, 1117–1121, 2005]. Participants (n = 356) viewed sentences containing articles and nouns of varying predictability, while their EEG was recorded. We measured ERPs preceding the critical words (namely, the semantic prediction potential), in conjunction with postword N400 patterns and individual neural metrics. ERP activity was compared with two measures of word predictability: cloze probability and lexical surprisal. In contrast to prior literature, semantic prediction potential amplitudes did not increase as cloze probability increased, suggesting that the component may not reflect prediction during natural language processing. Initial N400 results at the article provided evidence against phonological prediction in language, in line with Nieuwland and colleagues' findings. Strikingly, however, when the surprisal of the prior words in the sentence was included in the analysis, increases in article surprisal were associated with increased N400 amplitudes, consistent with prediction accounts. This relationship between surprisal and N400 amplitude was not observed when the surprisal of the two prior words was low, suggesting that expectation violations at the article may be overlooked under highly predictable conditions. Individual alpha frequency also modulated the relationship between article surprisal and the N400, emphasizing the importance of individual neural factors for prediction. The present study extends upon existing neurocognitive models of language and prediction more generally, by illuminating the flexible and subject-specific nature of predictive processing.
Recall as a Window into Hippocampally Defined Events
Authors: Rait Lindsay I. , Hutchinson J. Benjamin 
Published: May 2024

Abstract
We experience the present as a continuous stream of information, but often experience the past in parcels of unique events or episodes. Decades of research have helped to articulate how we perform this event segmentation in the moment, as well as how events and their boundaries influence what we later remember. More recently, neuroscientific research has suggested that the hippocampus plays a role at critical moments during event formation alongside its established role in enabling subsequent recall. Here, we review and explore the relationship between event processing and recall with the perspective that it can be uniquely characterized by the contributions of the hippocampus and its interactions with the rest of the brain. Specifically, we highlight a growing number of empirical studies suggesting that the hippocampus is important for processing events that have just ended, bridging the gap between the prior and current event, and influencing the contents and trajectories of recalled information. We also catalogue and summarize the multifaceted sets of findings concerning how recall is influenced by event structure. Lastly, we discuss several exciting directions for future research and how our understanding of events might be enriched by characterizing them in terms of the operations of different regions of the brain.
Cognitive abilities are associated with rapid dynamics of electrophysiological connectome states
Authors: Jun Suhnyoung , Malone Stephen M. , Alderson Thomas H. , Harper Jeremy , Hunt Ruskin H. , Thomas Kathleen M. , Wilson Sylia , Iacono William G. , Sadaghiani Sepideh 
Published: May 2024

Abstract
Time-varying changes in whole-brain connectivity patterns, or connectome state dynamics, hold significant implications for cognition. However, connectome dynamics at fast (&gt;1 Hz) timescales highly relevant to cognition are poorly understood due to the dominance of inherently slow fMRI in connectome studies. Here, we investigated the behavioral significance of rapid electrophysiological connectome dynamics using source-localized EEG connectomes during resting state (N = 926, 473 females). We focused on dynamic connectome features pertinent to individual differences, specifically those with established heritability: Fractional Occupancy (i.e., the overall duration spent in each recurrent connectome state) in beta and gamma bands and Transition Probability (i.e., the frequency of state switches) in theta, alpha, beta, and gamma bands. Canonical correlation analysis found a significant relationship between the heritable phenotypes of subsecond connectome dynamics and cognition. Specifically, principal components of Transition Probabilities in alpha (followed by theta and gamma bands) and a cognitive factor representing visuospatial processing (followed by verbal and auditory working memory) most notably contributed to the relationship. We conclude that rapid connectome state transitions shape individuals’ cognitive abilities and traits. Such subsecond connectome dynamics may inform about behavioral function and dysfunction and serve as endophenotypes for cognitive abilities.
Beyond ‘Saving Strangers’: Revisiting R2P as an Accountability Mechanism
Authors: Butler Michael J. 
Published: May 2024

Abstract
Nearly two decades after its formal endorsement by the international community, the Responsibility to Protect is stuck in a quagmire reminiscent of the contentious politics that both preceded and precipitated it. A once ambitious effort to transform notions of responsibility and practices of accountability regarding civilian protection and atrocity prevention, R2P has stagnated to such a degree that some have dismissed it as a dead letter. This research diagnoses the primary cause of that stagnation while also proposing a way forward for resuscitating R2P’s normative aims, via a return to R2P’s origins as an accountability mechanism for the provision of human rights and security.
Two Birds With One Stone? Governments’ Unilateral Declarations Before the ECtHR and the Reopening of Domestic Proceedings
Authors: Acconciamessa Lorenzo 
Published: May 2024

Abstract
This article deals with the interconnection between two relevant trends in the ECtHR’s case law: on the one hand, the increase of strike-out decisions of cases from the Court’s list, where the respondent governments issue unilateral declarations acknowledging the violations alleged by the applicants; on the other hand, the importance of the reopening of domestic proceedings as the most efficient, if not the only, means of achieving restitutio in integrum in respect of some types of violations. It analyses the practice concerning both acceptance of, by the Court, and non-compliance with, by the respondent governments, unilateral declarations in cases alleging violations, the redress of which demands a retrial or the reopening of the proceedings. The contribution aims at assessing whether the Court’s practice is appropriate for the purpose of fulfilling two important aims, namely the reduction of its backlog and the promotion of domestic authorities’ engagement with their obligations.