bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital access to culture
Authors: Weisen Marcus 
Published: June 2012

PurposeThe Jodi Awards exist to promote digital access to culture. This paper aims to give some background to the Awards and to profile the 2011 winner and commendation.Design/methodology/approachThe Jodi Awards are annual awards given to celebrate the best examples of using technology to make culture and cultural institutions accessible to people with a disability.FindingsMuch has already been achieved in using technology to widen access to museums, galleries and heritage venues but there is clear potential for more development, given the appropriate political will and policy change.Originality/valueThe Jodi Awards are unique in celebrating the use of technology in this way.
Pillars of peer support: advancing the role of peer support specialists in promoting recovery
Authors: Daniels Allen S. , Bergeson Susan , Fricks Larry , Ashenden Peter , Powell Ike 
Published: June 2012

PurposeThis paper aims to focus on The Pillars of Peer Support initiative, an ongoing project to examine and develop the principles of peer support services. These services are differentiated from peer support and define the parameters of a certified workforce that promotes recovery and fosters wellbeing. This process is based upon the lived experience of the peer support specialist.Design/methodology/approachA review of the literature indicates that a range of models and activities for peer support services have been developed, and established outcomes for these services are emerging. Since Medicaid has defined peer support services as reimbursable, the workforce has continued to expand. The Pillars of Peer Support initiative is designed to provide a standard set of principles to guide states in their work with Medicaid, and others in the development of this workforce.FindingsThe results of three Pillars of Peer Support summits are presented. This includes the 25 Pillars that have been developed and their role and use in state funded and other services. Additional findings support the process through which states and others can build these resources. A statement of how Peer Support Services fit within an essential health benefits package is also included.Originality/valueThe workforce of certified peer specialists is rapidly expanding. Their role in providing peer support services is identified, and principles to guide their professional roles are presented. This will help guide the field in the development and deployment of this important component of the healthcare delivery system.
Organizational justice and perceived organizational support
Authors: Fu Yang , Lihua Zhang 
Published: June 2012

PurposeThe purpose of this paper is to deepen the understanding of the relationship between perceived organizational support (POS) and organizational justice (distributive justice, procedural justice, and interactive justice), and to test the moderating effect of conscientiousness.Design/methodology/approachA survey was conducted to measure study variables. Data were obtained utilizing a field survey from a sample of 520 professional managers working in two industries (manufacturing industry and service industry) in China. Confirmatory factor analysis and moderated hierarchical analysis were used to test hitherto untested hypotheses.FindingsAs the result showed, controlling the effect of control variables (age, tenure, education and position), organizational justice (distributive justice, procedural justice, and interactive justice) had a positive effect on POS in the service sample; meanwhile, the interaction effect between distributive justice and conscientiousness has been shown to be significant in both the manufacturing and service samples.Research limitations/implicationsThe results have obvious implications for organizational justice and POS in organizations. However, the results are to be viewed in the light of common method variance and same source bias.Practical implicationsThe paper sheds light on the potential effects of conscientiousness, which strengthens the positive relationship between organizational justice and POS. Given the importance of conscientiousness, it may be worthwhile for leaders to stimulate managers' conscientiousness.Originality/valueThe paper examines how conscientiousness moderates the relationship between organizational justice and POS in both the manufacturing and service samples. It should be useful to academics and managers who want to understand the importance of conscientiousness.
Is work experience helpful to the success of venture creation?
Authors: Mai Yiyuan , Gu Xuena 
Published: June 2012

PurposeA lot of researches suggest that work experience plays an important role in the process of venture gestation. However, previous studies cannot explain “why there is a huge difference in the entrepreneurial success rate of those persons who have work experience”. Drawing insights from the model of “job embeddedness” in human resources management research field, the purpose of this paper is to examine the impact of on‐the‐job embeddedness on the centrality of entrepreneurial activities and the duration of venture creation activities.Design/methodology/approachMultiple regression is applied to test the hypotheses, using the dataset from the American “Panel Study of Entrepreneurial Dynamics” (PSED I).FindingsThe results suggest entrepreneur's previous work experience may result in scattered venture creation activities and the duration of entrepreneurial activity extended. It means the higher degree of on‐the‐job embedded the founder has, he or she feels more compatible with current job and more comfortable in the current work environment.Practical implicationsIndividuals who leave current jobs and start their own business are likely to promise personal losses (e.g. giving up colleagues, interesting projects or pleasant perks). So they consistently face an inordinate amount of risk and the entrepreneurial activities and longer term of venture gestation. If individual wants to start new firms quickly and efficiently, he should not only focus on the skills needed to perform his current job, but also should train his comprehensive management skills, even entrepreneurial ability by any possible ways during the work history of being an employee.Originality/valueThe paper enhances our understanding of the influence of employee's work history on the new venture creation by applying job embeddedness theory. It enlightens individuals who plan to create their own ventures to apply their on‐the‐job embeddedness to improve the success rate of entrepreneurial activities.
Efficacy of everolimus, a novel mTOR inhibitor, against basal‐like triple‐negative breast cancer cells
Authors: Yunokawa Mayu , Koizumi Fumiaki , Kitamura Yuka , Katanasaka Yasufumi , Okamoto Naoko , Kodaira Makoto , Yonemori Kan , Shimizu Chikako , Ando Masashi , Masutomi Kenkichi , Yoshida Teruhiko , Fujiwara Yasuhiro , Tamura Kenji 
Published: June 2012

Patients with triple‐negative breast cancers (TNBCs) typically have a poor prognosis because such cancers have no effective therapeutic targets, such as estrogen receptors for endocrine therapy or human epidermal growth factor receptor 2 (HER2) receptors for anti‐HER2 therapy. As the phosphatidylinositol 3′ kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) cascade is activated in TNBCs, mTOR is a potential molecular target for anticancer therapy. In this study, we investigated the antitumor activities of everolimus, an oral mTOR inhibitor, in nine TNBC cell lines. Everolimus effectively inhibited cell growth at concentrations under 100 nM (IC50) in five cell lines and even in the 1‐nM range in three of the five cell lines. To identify specific characteristics that could be used as predictive markers of efficacy, we evaluated the expressions of proteins in the mTOR cascade, basal markers, and cancer stem cell markers using western blotting, fluorescent in situ hybridization (FISH), or immunohistochemistry. All five of the sensitive cell lines were categorized as a basal‐like subtype positive for either epidermal growth factor receptor (EGFR) or CK5/6, although resistant cell lines were not of this subtype and tended to exhibit the characteristics of cancer stem cells, with decreased E‐cadherin and the increased expression of Snail or Twist. In vivo assays demonstrated antitumor activity in a mouse xenograft model of basal‐like breast cancer, rather than non‐basal breast cancer. These results suggest that everolimus has favorable activity against basal‐like subtypes of TNBCs. Epidermal growth factor receptor and CK5/6 are positive predictive markers of the TNBC response to everolimus, while cancer stem cell markers are negative predictive markers.
Antioxidant intake and allergic disease in children
Authors: Rosenlund H. , Magnusson J. , Kull I. , Håkansson N. , Wolk A. , Pershagen G. , Wickman M. , Bergström A. 
Published: June 2012

SummaryBackgroundAntioxidant intake may reduce the risk of allergic disease by protecting against oxidative tissue damage. Major sources of antioxidants in the Western world are fruits, vegetables (vitamin C, β‐carotene, α‐tocopherol), meat and milk (selenium, magnesium, zinc). Children may exclude or eat less of some fruits and vegetables due to cross‐reactivity between pollen and these foods, complicating assessment of causal relationships.ObjectiveTo investigate the association between dietary antioxidant intake and allergic disease, taking potential reverse causation into account.MethodsData on 2442 8‐year‐old children from the Swedish birth cohort study BAMSE were analysed. Children with completed parental questionnaires on exposures and health, including a food‐frequency questionnaire and who provided a blood sample were included. Associations between antioxidant intake during the past year and current allergic disease were analysed using logistic regression.ResultsAn inverse association was observed between intake of β‐carotene and rhinitis (ORadj, highest vs. lowest quartile, 0.67, 95% CI 0.49–0.93). Magnesium intake was inversely related to asthma (ORadj, 0.65, 95% CI 0.42–1.00) and atopic sensitisation (ORadj, 0.78, 95% CI 0.61–1.00). Following exclusion of children who avoided certain fruits, vegetables or milk due to allergic symptoms (n = 285), the inverse association remained between magnesium intake and asthma (ORadj, 0.58, 95% CI 0.35–0.98), whereas all other associations became non‐significant.Conclusion and clinical relevanceDiet modifications due to allergy may affect the antioxidant intake and needs to be considered when investigating the relationship between diet and allergic disease. Magnesium intake seems to have a protective effect on childhood asthma.
Pregnancy‐associated plasma protein‐A is related to gender and to adipocytokine levels: results of The Health Survey of Catalonia
Authors: Joaquín Clara , Granada Maria L. , Pastor Cruz , Castell Conxa , Puig Rocío , Alonso Núria , Serra Enric , Sanmartí Anna , Foz Marius , Puig‐Domingo Manel 
Published: June 2012

SummaryObjectivePregnancy‐associated plasma protein‐A (PAPP‐A) is a protease promoting IGF1 tissue availability and considered as a new biomarker of cardiovascular disease.AimTo evaluate the relationship between PAPP‐A concentrations and anthropometric variables, physical activity, smoking status, glucose homoeostasis and adipocytokines in healthy adults.Design and methodsOne hundred and forty‐nine subjects (77 women; mean age 39·7 ± 14 years; mean BMI 23·7 ± 1·9 kg/m2) were randomly selected from 8000 adults of The Health Survey of Catalonia. Possible effects of gender, age, body composition, smoking status, physical activity, glucose homoeostasis and adipocytokines on PAPP‐A concentrations were assessed.ResultsPregnancy‐associated plasma protein‐A was significantly higher in men than in women [ 1·04 (0·61–0·44) vs 0·61 (0·41–0·90) μIU/ml; P < 0·0001]; there were no differences in relation to physical activity or smoking status. PAPP‐A showed a negative correlation with leptin in men (P = 0·01) and women (P = 0·05), and a positive correlation with adiponectin (P = 0·006) in women and a trend (P = 0·073) in men. Homoeostasis model assessment of insulin resistance (HOMA‐IR) showed a negative correlation with PAPP‐A only in women (P = 0·019). No association was found with blood pressure, IGF1, lipids or glucose in either gender. When a multiple regression analysis was performed including gender, age, BMI, waist‐hip ratio, HOMA‐IR, adiponectin and leptin as confounders, PAPP‐A was independently correlated with adiponectin (β = 0·23; P = 0·02) and leptin (β = −0·33; P = 0·04).ConclusionsOur study shows a sexual dimorphism of PAPP‐A, and a possible influence of leptin and adiponectin on its concentrations in healthy subjects. The mechanisms responsible for this relationship remain to be determined.
Factors determining weight gain in adults and relation with glucose tolerance
Authors: Soriguer Federico , Rojo‐Martínez Gemma , Valdés Sergio , Tapia Maria José , Botas Patricia , Morcillo Sonsoles , Delgado Elías , Esteva Isabel , Ruiz de Adana Maria Soledad , Almaraz María Cruz , Diaz‐Cadorniga Francisco , Gutierrez‐Repiso Carolina , Garcia‐Fuentes Eduardo 
Published: June 2012

SummaryObjectiveModifications in lifestyle, diet and certain clinical events are major contributors for the high prevalence of obesity. The aim of this study was to assess factors associated with weight gain in a population of Spanish adults.DesignThe study was undertaken in two population‐based cohorts from the north and the south of Spain (baseline and after 6 years). The Asturias Study, in the north, included 1034 persons aged 30–75 years, of whom 701 were reassessed. The Pizarra Study, in the south, included 1226 persons aged 18–65 years, of whom 783 were re‐evaluated. Both studies involved a nutritional questionnaire, a physical examination and an oral glucose tolerance test (OGTT).ResultsDuring the follow‐up, 32·3% of the participants lost weight, 34·5% gained fewer than 4 kg and 33·2% gained more than 4 kg. Weight gain was greater in persons younger than 50 years and in those with an initial body mass index below 30. Weight gain was associated with a greater incidence of type 2 diabetes mellitus (T2DM) and abnormal glucose tolerance, whereas weight loss in persons with these disorders was associated with a normal OGTT 6 years later. Persons who took less exercise and those who reported a higher daily calorie intake experienced greater weight gain.ConclusionThe longitudinal changes in weight affect the development of T2DM and abnormal glucose tolerance. The weight is a dynamic phenomenon affected by several social customs.
Acromegalic cardiomyopathy in an extensively admixed population: is there a role for GH/IGF‐I axis?
Authors: Nascimento Gilvan Cortês , de Oliveira Marina Torres , Carvalho Viviane Chaves , Lopes Maria Honorina Cordeiro , Guimarães Sá Adriana Maria , Souza Marinilde Teles , de Souza Paiva Ferreira Adalgisa , Ferreira Pedro Antônio Muniz , Faria Manuel dos Santos 
Published: June 2012

SummaryBackgroundA specific acromegaly‐related cardiomyopathy has been described in the literature, largely in Caucasians, which is independent of other risk factors, mainly hypertension.ObjectiveThis study assessed the cardiac changes in acromegalics of significant ethnic diversity and also the relevance of the aetiopathogenic factors involved, such as disease activity and hypertension.DesignIt is a cross‐sectional study with a comparative control group.Patients and methodsIn this study, 37 acromegalic patients (20 Intermediate‐skinned (IS), 14 Dark‐skinned (DS) and three Light‐skinned (LS) individuals) and 74 controls matched by age, gender and hypertension were evaluated. Cardiac morphology and function were addressed using echocardiography parameters.ResultsThe mean age of patients was 46·9 ± 12·8 years, with 67·6% being women and 43·2% hypertensive. The prevalence of left ventricular hypertrophy (LVH) between acromegalics was 56·8% vs 10·8% in the controls (P < 0·001). About 86% of patients with LVH had active disease (P = 0·023). Logistic regression revealed that disease activity presented a stronger association (OR = 5·925; CI = 1·085–32·351; P = 0·040) with LVH than hypertension (OR = 3·237; CI = 0·702–14·924; P = 0·132). When DS acromegalics were compared with IS ones, no statistically significant differences were observed.ConclusionChronically hyperactive somatotropic axis remains as an independent and determining factor in the development of left ventricular hypertrophy, as it is more associated with this condition than hypertension in a largely admixed population with a high degree of African ancestry.
Large‐scale development of cost‐effective SNP marker assays for diversity assessment and genetic mapping in chickpea and comparative mapping in legumes
Authors: Hiremath Pavana J. , Kumar Ashish , Penmetsa Ramachandra Varma , Farmer Andrew , Schlueter Jessica A. , Chamarthi Siva K. , Whaley Adam M. , Carrasquilla‐Garcia Noelia , Gaur Pooran M. , Upadhyaya Hari D. , Kavi Kishor Polavarapu B. , Shah Trushar M. , Cook Douglas R. , Varshney Rajeev K. 
Published: June 2012

SummaryA set of 2486 single nucleotide polymorphisms (SNPs) were compiled in chickpea using four approaches, namely (i) Solexa/Illumina sequencing (1409), (ii) amplicon sequencing of tentative orthologous genes (TOGs) (604), (iii) mining of expressed sequence tags (ESTs) (286) and (iv) sequencing of candidate genes (187). Conversion of these SNPs to the cost‐effective and flexible throughput Competitive Allele Specific PCR (KASPar) assays generated successful assays for 2005 SNPs. These marker assays have been designated as Chickpea KASPar Assay Markers (CKAMs). Screening of 70 genotypes including 58 diverse chickpea accessions and 12 BC3F2 lines showed 1341 CKAMs as being polymorphic. Genetic analysis of these data clustered chickpea accessions based on geographical origin. Genotyping data generated for 671 CKAMs on the reference mapping population (Cicer arietinum ICC 4958 × Cicer reticulatum PI 489777) were compiled with 317 unpublished TOG‐SNPs and 396 published markers for developing the genetic map. As a result, a second‐generation genetic map comprising 1328 marker loci including novel 625 CKAMs, 314 TOG‐SNPs and 389 published marker loci with an average inter‐marker distance of 0.59 cM was constructed. Detailed analyses of 1064 mapped loci of this second‐generation chickpea genetic map showed a higher degree of synteny with genome of Medicago truncatula, followed by Glycine max, Lotus japonicus and least with Vigna unguiculata. Development of these cost‐effective CKAMs for SNP genotyping will be useful not only for genetics research and breeding applications in chickpea, but also for utilizing genome information from other sequenced or model legumes.
Advected Tangent Curves: A General Scheme for Characteristic Curves of Flow Fields
Authors: Weinkauf T. , Hege H.‐C. , Theisel H. 
Published: June 2012

AbstractWe present the first general scheme to describe all four types of characteristic curves of flow fields – stream, path, streak, and time lines – as tangent curves of a derived vector field. Thus, all these lines can be obtained by a simple integration of an autonomous ODE system. Our approach draws on the principal ideas of the recently introduced tangent curve description of streak lines. We provide the first description of time lines as tangent curves of a derived vector field, which could previously only be constructed in a geometric manner. Furthermore, our scheme gives rise to new types of curves. In particular, we introduce advected stream lines as a parameter‐free variant of the time line metaphor. With our novel mathematical description of characteristic curves, a large number of feature extraction and analysis tools becomes available for all types of characteristic curves, which were previously only available for stream and path lines. We will highlight some of these possible applications including the computation of time line curvature fields and the extraction of cores of swirling advected stream lines.
Clofarabine‐containing conditioning regimen for allo‐SCT in AML/ALL patients: a survey from the Acute Leukemia Working Party of EBMT
Authors: Chevallier Patrice , Labopin Myriam , Buchholz Stefanie , Ganser Arnold , Ciceri Fabio , Lioure Bruno , Faul Chistoph , Guillerm Gaelle , Finke Juergen , Huynh Anne , Schubert Joerg , Kolb Hans‐Jochem , Polge Emmanuelle , Nagler Arnon , Mohty Mohamad 
Published: June 2012

AbstractClofarabine (CLO), a second‐generation purine analogue, has demonstrated an efficient anti‐leukemia activity while showing a favorable toxicity profile. This retrospective multicenter report assessed the outcome of 90 patients who received a CLO‐containing conditioning regimen before allo‐SCT for AML (n = 69) or ALL (n = 21). Median age was 42 yr at transplant. The majority of cases (n = 66) presented with an active disease at transplant while 38 patients had received previous transplantation(s). A total of 88 and two patients received a reduced‐intensity conditioning or a myeloablative regimen, respectively. Engraftment was achieved in 97% of evaluable patients. With a median follow‐up of 14 months (range, 1–45), the 2‐year OS, LFS, relapse, and NRM rates were 28 ± 5%, 23 ± 5%, 41 ± 6%, and 35 ± 5%, respectively. When comparing AML and ALL patients, OS and LFS were significantly higher for AML (OS, 35 ± 6% vs. 0%, P < 0.0001); LFS: 30 ± 6% vs. 0%, P < 0.0001). In a Cox multivariate analysis, an AML diagnosis was the only factor associated with a better LFS (HR = 0.37; 95%CI, 0.21–0.66; P = 0.001). We conclude that a CLO‐containing conditioning regimen prior to allo‐SCT might be an effective treatment. Prospective studies are needed to evaluate the potential role of CLO as part of conditioning regimens in acute leukemias.
Influence of finishing textile materials on the reduction of skin irritations
Authors: Strese Helene , Kuck Monika , Benken Rainer , Fluhr Joachim W. , Schanzer Sabine , Richter Heike , Meinke Martina C. , Beuthan Jürgen , Benderoth Christian , Frankowski Gottfried , Sterry Wolfram , Lademann Jürgen 
Published: June 2012

BackgroundAn increasing number of people is reported to have sensitive skin. Consequently, the development of textile materials with comfortable wearing properties has become a major interest. One method to create a pleasant sensation of textile materials on the skin is to coat them with silk proteins. This technologically complex procedure requires both optimization and control.MethodsThe present study was aimed to characterize the subjective perception of different textiles and to objectively assess their influence on skin morphology with non‐invasive optical techniques like optical coherence tomography (OCT), laser scanning microscopy (LSM) and optical surface profilometry (OP). Furthermore, optical methods were used to characterize surface properties of different textile fabrics.ResultsIn the present study it could be shown that optical non‐invasive methods, as applied in cosmetology and dermatology are suited to characterize the structural properties of fabrics and the effects that textile materials have on the skin. Here, both unfinished textile materials and fabrics finished with silk protein coating were investigated by OCT, LSM and OP. In addition, volunteers were interviewed about their subjective sensation when these fabrics were in contact with their skin.ConclusionThe study showed that optical methods could be applied to compare textile materials in vitro, which permit the wearing comfort to be predicted and in vivo perception on the skin.