bluuebunny/crossref_metadata_2025_split huggingface dataset:
A 10-Year Personal History of the Radiological Operations Support Specialist
Authors: Irwin William 
Published: February 2025

Abstract
The Radiological Operations Support Specialist Program accomplished one of the hardest outcomes—to build and sustain an all-volunteer organization from a few people to hundreds. Even more, the organization created a cadre of newly certified technical specialists able to help the local, state, and federal authorities respond better to a radiological or nuclear catastrophe so our nation can recover faster. The effort has had the endorsement of the United States Congress and the support of three important federal agencies and the national partnership for radiation protection, the Conference of Radiation Control Program Directors. The development of the Radiological Operations Support Specialist (ROSS) occurred over the same time when numerous other references, tools, trainings, and exercises were ushered in. A 10-year period that may be the most remarkable unified radiological emergency preparedness effort yet undertaken. This article describes the key motivators and many of the guidance documents and technical tools and capabilities that came together over the last 10 years that helped build not just an organization of radiological and nuclear emergency response and recovery subject matter experts that the nation needs, but also nearly everything to sustain them effectively for decades to come.
Shared Decision-Making in Severe Aortic Stenosis
Authors: van Beek-Peeters Judith J.A.M. , Habibovic Mirela , Faes Miriam C. , van der Meer Jop B.L. , Pel-Littel Ruth E. , van Geldorp Martijn W.A. , Van den Branden Ben J.L. , van der Meer Nardo J.M. , Minkman Mirella M.N. 
Published: February 2025

Background
The experiences and preferences of older patients regarding shared decision-making (SDM) for managing severe aortic stenosis (AS) and its impact on health outcomes are not well known.

Objective
The purpose of this study was to provide insight into the experiences, preferences, and needs for SDM of older patients with severe AS and the associations between perceived SDM levels and patients' quality of life, depression, and anxiety.

Methods
A descriptive, exploratory multiple-methods study was conducted using a survey, focus groups, and individual interviews with patients 70 years and older with severe AS. Data were collected at baseline and at 3-month follow-up. Quantitative data were analyzed using multivariate linear regression and quantitative data using qualitative thematic analysis.

Results
Quantitative analysis (n = 120) showed that 29.6% of patients reported maximum scores for the perceived SDM level. In addition, the perceived SDM level was significantly associated with the quality of life category environment (B = 2.75; 95% confidence interval, 0.90–4.61; P = .004). Professionals' identification of discussion partners was reported by 41.3% of patients, and 52% of patients reported professionals' exploration of patients' daily lives. For future decision-making, 55.6% of patients preferred a collaborative role. Qualitative analysis of 2 focus groups (n = 10) and interviews (n = 7) revealed patients' preference for informal caregivers' support for decision-making. Patients expressed caution in sharing views on their daily lives and expectations and suggested better preparation and goal exploration for decision-making.

Conclusions
To align with SDM and personalize the decision-making process, healthcare professionals must foster patient input and engage informal caregivers. Patients must reflect on their daily activities to define their treatment goals.
The Importance of Fostering Trust in Service Delivery With Child and Youth Survivors of Commercial Sexual Exploitation
Authors: O’Brien Jennifer E. , Mitchell Kimberly J. , Jones Lisa M. , Chinwokwu-Njemanze Chioma 
Published: February 2025

ABSTRACT
The commercial sexual exploitation (CSE) of children occurs when individuals under the age of 18 years exchange sex/sexual acts for goods, services, drugs, or money. Current research suggests that many survivors of CSE had contact with a variety of professionals during their victimization experiences; however, many child CSE survivors are wary of those working with them in professional roles, including those seeking to engage them in regular care. The current study used qualitative interviews with professionals working with children who have experienced CSE to explore their strategies for facilitating trust. Qualitative data were collected from 80 diverse professionals from 11 different cities across the United States. Grounded theory analysis revealed three main themes regarding the facilitation of trust building: (a) clear communication, (b) humanization of experience, and (c) boundaries/limits. Findings from the current study offer practical implications for professionals, such as nurses, who are interested in facilitating rapport with children who have experienced CSE victimization in the interest of primary and tertiary prevention. Future research should focus on survivor perspectives to explore how professional’s approaches are experienced by the populations they purport to serve.
Comparing Tenecteplase and Alteplase for Acute Ischemic Stroke
Authors: Tu Chen-Chen , Mao Hanqi Kelly , Wessol Jennifer L. 
Published: February 2025

ABSTRACT

BACKGROUND: Acute ischemic stroke (AIS) is a leading cause of mortality and disability. Patients who receive thrombolytic therapy promptly tend to have better outcomes. Although alteplase (tPA) is the standard Food and Drug Administration–approved thrombolytic for AIS treatment, recent American Heart Association guidelines suggest that tenecteplase (TNK) can be used as an alternative. This project compares the cost-effectiveness and clinical outcomes of TNK versus tPA in AIS treatment. Key outcomes include door-to-needle time, length of stay, National Institutes of Health Stroke Scale scores, and the incidence of hemorrhagic conversion events. METHODS: The project involved retrospective analysis through medical chart reviews at a thrombectomy-capable stroke center in a Pacific Northwest community hospital. Data were collected from 175 AIS patients treated with either tPA (82) or TNK (93) between March 2022 and December 2023. Patients eligible for thrombolytic therapy received tPA before March 15, 2023, with TNK used thereafter. Selection criteria adhered to American Heart Association guidelines and clinicians' judgment. RESULTS: Although door-to-needle times were similar (P = .20), excluding outliers revealed a significant difference favoring TNK (P = .04). No significant group differences were observed for demographics, National Institutes of Health Stroke Scale scores, length of stay, or post–intracerebral hemorrhage rates. Tenecteplase use resulted in over $40 000 in medication savings during the project period. CONCLUSION: Tenecteplase offers comparable safety and efficacy to tPA for treating AIS, with the added benefit of cost savings. Although clinical outcomes did not significantly differ between the 2 drugs, TNK's reduced cost and ease of administration make it an attractive option, particularly in resource-limited settings. These results support the current organizational treatment protocol favoring TNK.
Perspectives on early health economic evaluations of RNA therapies targeted at lipoprotein(a)
Authors: Burvill Angela , Watts Gerald F. , Ademi Zanfina 
Published: February 2025

Purpose of review
Early health economic evaluations of new medications are useful, as they consider the implications for health services.
We reviewed recent literature on expected clinical outcomes of lowering of elevated plasma lipoprotein(a) [Lp(a)] in secondary prevention, which is essential information on effectiveness for economic evaluations.
We reviewed a recent early economic evaluation of RNA therapies targeted at Lp(a).

Recent findings
RNA-based therapies, if approved, would likely be used initially in adults with established atherosclerotic cardiovascular disease (ASCVD) and very high Lp(a). Adults with ASCVD have high absolute risk of recurrent events and elevated Lp(a) serves as a risk-enhancing factor.
Potent lowering of Lp(a) in secondary prevention may be associated with significant relative risk reductions of coronary heart disease or ASCVD events; this needs confirmation in currently ongoing and future clinical trials.
One economic evaluation has estimated the value of olpasiran and pelacarsen, at various willingness-to-pay thresholds, compared with standard-of-care secondary prevention.

Summary
Early economic evaluations estimate longer-term clinical benefits and cost consequences associated with new medications.
Existing casual evidence of Lp(a) and cardiovascular disease can be used in early economic evaluations as best available evidence, while awaiting results from major cardiovascular outcomes trials.
Serum Exosomal miR-216a Contributes to Acute Pancreatitis-Associated Acute Lung Injury by Enhancing Endothelial cell Vascular Permeability via Downregulating LAMC1
Authors: Zhu Huiyun , Zhou Xianzhu , Sun Xingcheng , Fu Chunting , Li Ge , Dong Xiaoyang , Kong Xiangyu , Su Xiaoju , Du Yiqi 
Published: February 2025

Background:
Acute pancreatitis (AP) is an internal medical emergency disease, with fatal complications including acute lung injury (ALI). Recent studies have highlighted the critical roles of exosomal microRNAs (miRNAs) in AP-ALI. In the present study, we aim to investigate the role of serum exosomal miR-216a in AP-ALI and its underlying mechanisms.

Methods:
The levels of miR-216a in patients and rat models with AP and AP-ALI were assessed via real-time quantitative PCR (qRT-PCR) analysis. Patient and rat blood exosomes were isolated and co-cultured with HUVECs. The permeability of HUVECs was evaluated via trans-endothelial electrical resistance (TEER) assay. Bioinformatics predicting and luciferase reporter assays were used to identified potential targets of miR-216a. In addition, miR-216a mimic and LAMC1 overexpressed plasmid were constructed to identify the effects of miR-216a/LAMC1 axis on endothelial cell permeability in vitro. Anti-miR-216a and exosomes were used to identify the critical role of exosomal miR-216a in AP-ALI in vivo.

Results:
The findings indicated that there was a significant upregulation of miR-216a in AP-ALI patients and rat models. The occurrence of ALI during AP progression promoted the expression of serum exosomal miR-216a. Exosomal could promote HUVECs permeability by releasing miR-216a. For target studies, miR-216a was found to bind to LAMC1 to regulate its transcription level. MiR-216a-mediated downregulation of LAMC1 lead to increased permeability of HUVECs. Exosome-derived miR-216a has also been proved to promote lung damage in AP-ALI rats.

Conclusions:
In summary, serum exosomal miR-216a can promote the onset and progression of AP-ALI by augmenting endothelial cell vascular permeability. This finding presents a theoretical basis for exploring new therapeutic approaches targeting AP-ALI.
Association Between Nurse Turnover and Nurses’ Perception of Patient Outcomes in Acute Care Hospitals in South Korea
Authors: Bae Sung-Heui 
Published: February 2025

Background:
High turnover rates among nurses are a global concern. Previous studies show the negative impact on quality of care.

Purpose:
The purpose of this study was to examine the relationship between nurse turnover and nurse’s perceptions of patient outcomes.

Methods:
A cross-sectional study design was used. Nurses working in 35 general hospitals in South Korea were invited to participate in a survey assessing their perceptions of patient outcomes, including quality of care, patient safety, and adverse events. Nurse turnover was measured for the prior 6 months.

Results:
Data from 159 nurses were analyzed. There was a significant positive relationship between turnover rates and perceptions of poor quality of care, after controlling for demographic and work-related characteristics. Nurse turnover was not significantly associated with perceptions of patient safety or adverse events.

Conclusions:
The negative consequence of nurse turnover on patient outcomes is partially supported in this study.
Diagnostic Performance of Spurling’s Test for the Assessment Sub-acute and Chronic Cervical Radiculopathy: A Systematic Review and Meta-Analysis
Authors: Lin Long-Huei , Lin Ting-Yu , Chang Ke-Vin , Tzang Chih-Chen , Wu Wei-Ting , Özçakar Levent 
Published: February 2025

ABSTRACT

Objective
Spurling’s test (ST) is commonly used to diagnose cervical radiculopathy (CR); however, its diagnostic accuracy varies across studies. This systematic review and meta-analysis aim to evaluate the diagnostic performance of ST for CR.

Design
A systematic search of PubMed, ClinicalTrials.gov, Cochrane Library, and Physiotherapy Database was conducted following PRISMA guidelines. Studies assessing ST against imaging or electrodiagnostic tests were included. A bivariate random-effects model calculated pooled sensitivity, specificity, likelihood ratios (LR), and log diagnostic odds ratios.

Results
Eight studies met the inclusion criteria. The pooled sensitivity of ST was 0.53 (95% confidence interval [CI]: 0.29–0.78), higher with imaging (0.67) than with electrodiagnostic testing (0.31). Combining neck rotation or extension increased sensitivity to 0.67, compared to 0.31 without. The pooled specificity was 0.92 (95% CI: 0.88–0.96), 0.93 with imaging and 0.91 with electrodiagnostic testing. The pooled positive LR was 3.28, negative LR was 0.28, and the log diagnostic odds ratio was 2.74.

Conclusions
ST is highly specific but has low sensitivity for CR diagnosis, making it better suited for confirmation than screening. Sensitivity may improve with added maneuvers and imaging as a reference.
Physical activity is associated with better cognitive measures of verbal fluency, immediate recall, delayed recall, and numeracy in older people with osteoarthritis and moderate-severe pain
Authors: Ogrezeanu Daniel C. , Núñez-Cortés Rodrigo , Andersen Lars Louis , López-Bueno Rubén , Suso-Martí Luis , Salazar-Méndez Joaquín , Cruz-Montecinos Carlos , Calatayud Joaquín 
Published: February 2025

Abstract

Objective
This cross-sectional study assesses the relationship between physical activity (PA) and crucial indicators of cognitive function in older adults with osteoarthritis and moderate-severe pain.

Design
Data were derived from the 9th wave of the Survey of Health, Ageing and Retirement in Europe (SHARE), conducted among older people in 27 European countries and Israel. Cognitive measures of verbal fluency, immediate recall, delayed recall, and numeracy were included, as well as self-reports of PA level. Multivariable linear regression analysis was applied to test associations, adjusted for various demographic and lifestyle factors.

Results
7,429 participants were included. A positive association was found between performing moderate PA more than once a week and better verbal fluency (β = 2.16; 95%CI: 1.75-2.58), immediate recall (β = 0.51; 95%CI: 0.41-0.60), delayed recall (β = 0.45; 95%CI: 0.34-0.57) and numeracy (β = 0.43; 95%CI: 0.34-0.52) compared to hardly ever or never performing PA. Additionally, a positive but weaker association was found between performing vigorous PA once a week and better verbal fluency (β = 1.52, 95%CI: 1.02-2.02), immediate recall (β = 0.29, 95%CI: 0.18-0.41), delayed recall (β = 0.41, 95%CI: 0.27-0.54) and numeracy (β = 0.33, 95%CI: 0.23-0.44).

Conclusions
Regular PA, particularly moderate intensity, is positively associated with better cognitive measures of verbal fluency, immediate recall, delayed recall, and numeracy, with the strongest benefits observed for verbal fluency.
A Multiplex qPCR to Differentiate Monkeypox Virus Clades
Authors: Williams Christopher T. , Romero-Ramirez Alessandra , Semiu Adeleye Adesola , Ifabumuyi Samuel Oluwafunmbi , Gould Susan , Wooding Dominic , Allen Collette , Somasundaran Anushri , Mkpuma Nicodemus Nnabuike , Gado Dorcas , Adole Jolly Amoche , Amoo Abdulakeem Eniola , Adeyemi Abisola Ajoke , de Jarcy Laure Bosquillon , Goffinet Christine , Dunning Jake , Semple Malcolm G ,   ISARIC CCP UK investigators, Bahizire Esto , Akinpelu Afolabi , Fletcher Thomas E , Cubas-Atienzar Ana , Leggio Cristina , Adedeji Adeyinka , Omoare Adesuyi A. , Edwards Thomas 
Published: February 2025

AbstractWe designed a multiplex qPCR to differentiate monkeypox virus clades. In evaluations using clinical samples collected in the UK and Nigeria, the assay had an overall sensitivity of 78% (95% CI: 67.67% to 86.14%) and specificity of 94% (95% CI: 80.84% to 99.30%); for samples under Ct35 sensitivity was 98% (95% CI: 91.72% to 99.96%) and specificity was 94% (95% CI: 80.84% to 99.30%).
Serological evidence and factors associated to liver damage in malaria-typhoid infected patients consulting in two health facilities, Yaoundé-Cameroon
Authors: Essam Madeleine Yvanna Nyangono , Kouam Arnaud Fondjo , Fepa Armelle Gaelle Kwesseu , Seukep Armel Jackson , Zeuko’o Elisabeth Menkem , Somene Felicité Syntia Douanla , Nembo Nembu Erastus , Moundipa Paul Fewou , Njayou Frédéric Nico 
Published: February 2025

AbstractMalaria and typhoid fever remain major health issues in developing countries like Cameroon, with frequent co-infections. The potential liver damage caused by their respective causative pathogens is overlooked in health management, posing a significant risk of severe liver injury and worsening patient conditions. Accordingly, this study investigated the risk factors associated to liver damage in febrile patients with malaria, typhoid fever, or co-infection at the Obili District Medical Center and Mvog-Betsi Dominican Hospital Center, Yaoundé, Cameroon. During 8 months, 350 febrile patients were evaluated for their adherence to preventive measures concerning malaria and typhoid fever using a structured questionnaire. Blood samples were analyzed forPlasmodiumspecies andSalmonellaantibodies and liver enzyme levels were measured. Liver damage was assessed employing the Roussel Uclaf Causality Assessment Method. Risk factors for infections and liver damage were identified using Fisher’s Exact and Chi-Square tests, with significance set at P<0.05. Among participants tested, 129 (36.86%) and 106 (30.29%) were positive for malaria and typhoid, respectively, while 56 (16.00%) were co-infected. Men (58/118 and 44/118) were more affected than women (71/232 and 62/232) for both malaria and typhoid. Participants aged between 20 and 40 years were the most affected by malaria (21.4%) and typhoid fever (17.4%). The non-use of mosquito nets, presence of standing water, bushes, and garbage dumps near residences were significant risk factors (Relative risk: RR>2.1; P<0.0001) for contracting malaria or typhoid fever. The co-infection status (Chi-2 = 18.30; P<0.0001), parasite density (Chi-2 = 9.8; P=0.0074), and delay before consulting (Chi-2 = 13.23; P=0.0013) were significant risk factors for the occurrence of liver injuries. Our findings demonstrated that the alteration of liver enzyme activities, reflecting liver damages among patients with malaria, typhoid, or malaria-typhoid co-infection, is a reality and should be considered during the patient’s treatment.
Cuffless Photoplethysmography Device for Continuous Monitoring of Blood Pressure
Authors: Hellou Elias , Jamal Tamer , Zuroff Elchanan , Kalhor Parvin , Delgado-Lelievre Maria , Lerman Lilach O. , Lerman Amir , Kachel Erez , Zoghby Ziad 
Published: February 2025

AbstractIntroductionAccurate and convenient monitoring of BP is challenging and relies on cuff-based devices or in the postoperative and intensive care settings, on invasive measurements. The aim of this study was to prospectively evaluate the accuracy of BP measurements obtained from a novel, commercially available cuffless, non-invasive photoplethysmography (PPG)-based chest patch monitor compared to the reference standard invasive arterial pressure (IAP) monitoring, in patients after cardiac surgery.MethodsThis single center prospective study enrolled adults who underwent cardiac surgery. The PPG-based data were compared to IAP as part of standard of care. Bland-Altman plots and Pearson’s correlations were used to assess the accuracy between the two techniques.ResultsNinety-six patients consented for the study. Mean age was 63.2±12.2 years (range 24 to 84), and 32 (33%) were women. Average monitoring time was 25.6±17.2. In total, we evaluated 78659 readings for systolic BP (SBP), 78818 for diastolic BP (DBP), and 92544 for HR analysis. These yielded correlation coefficients of r=0.959, 0.973, 0.966, and 0.962 for SBP, DBP, mean arterial pressure (MAP), and heart rate (HR), respectively. The Bland-Altman analysis showed a bias±SD of 0.1±4.8 mmHg for SBP; 0.4±2.1 mmHg for DBP; 0.26±2.6 mmHg for MAP, and 0.15±3.6 beats per minutes for HR. 95% of SBP, and 99.9% of DBP measurements were within 10 mmHg of the reference measurement.ConclusionCuffless device offers a high level of accuracy of BP and HR, supporting the use of this novel noninvasive tool for continuous BP monitoring. Further studies are needed to validate those findings.
Combinatorial effects ofZingiber officinaleandCitrus limonjuices: Hypolipidemic and antioxidant insights fromin vivo,in vitro, andin silicoinvestigations
Authors: Bekkouch Oussama , Bekkouch Ayoub , Elbouny Hamza , Touiss Ilham , El Assri Soufiane , Choukri Mohammed , Bourhia Mohammed , Kim Kiryang , Kang Sojin , Choi Min , Choi Jinwon , Kim Hyo Jeong , Ahn Chi-Hoon , Park Moon Nyeo , Kim Bonglee , Amrani Souliman 
Published: February 2025

AbstractThe combined use ofZingiber officinale(ginger) andCitrus limon(lemon) has long been valued in traditional medicine for their significant therapeutic properties, particularly in supporting cardiovascular health. However, their synergistic effects on hyperlipidemia and oxidative stress, both critical risk factors for cardiovascular diseases, remain underexplored.This study employed a multidisciplinary approach includingin vivo(mice model with triton WR-1339-induced hyperlipidemia),in vitro(antioxidant assays such as DPPH and ABTS), andin silico(molecular docking targeting HMG-CoA reductase) to evaluate the hypolipidemic and antioxidant potential of ginger and lemon juices. Phytochemical analysis identified high concentrations of bioactive compounds, with ginger juice containing 6-gingerol (15.54% peak area) and lemon juice featuring hesperidin (13.85% peak area) and rutin (5.57% peak area). These compounds were instrumental in the observed pharmacological effects.The combined formulation significantly improved lipid profiles, reducing total cholesterol by 54.3%, triglycerides by 49.8%, and LDL by 58.1% while increasing HDL by 47.6% compared to hyperlipidemic controls (p < 0.05). Antioxidant assays revealed high free radical scavenging activity, with IC50values of 30.92 ± 2.00 µg/mL for ABTS and 44.94 ± 1.02 µg/mL for DPPH in the combined formulation. Molecular docking confirmed strong binding affinities, with hesperidin and 6-gingerol showing binding energies of -10.4 kcal/mol and -9.6 kcal/mol, respectively, against HMG-CoA reductase.In conclusion, combiningZingiber officinaleandCitrus limonjuices demonstrates robust hypolipidemic and antioxidant effects, significantly outperforming the individual juices. These results support their potential as natural therapeutic agents for managing hyperlipidemia and oxidative stress. Further clinical studies are recommended to validate these promising findings and explore their application in nutraceutical development.