bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pedobarographic Analysis and Quality of Life After Lisfranc Fracture Dislocation
Authors: Schepers Tim , Kieboom Brenda , Diggele Peter van , Patka Peter , Lieshout Esther MM Van 
Published: October 2010

Background: Few studies on tarsometatarsal fracture dislocations report on plantar pressure analysis and quality of life. The primary aim of this study was to determine the added value of plantar pressure analysis. The secondary aim was to determine quality of life and functional outcome. Materials and Methods: With a median followup of 76 months, 26 patients with an isolated Lisfrane injury participated. The Short Form 36 (SF-36) was used to determine the health related quality of life. Functional outcome was assessed with the American Orthopaedic Foot Ankle Society (AOFAS) midfoot score and a Visual Analog Scale (VAS). A Wilcoxon Signed Rank test was used to assess whether plantar pressure and foot position variables differed between the injured and uninjured foot. Correlations between outcome data were identified using Spearman Rank Correlation. Results: With respect to the plantar pressure analysis, a reduced contact time of the forefoot was found for the injured foot compared with the contralateral side ( p = 0.045). The injured side showed reduced contact surface of the forefoot ( p = 0.048) and an increased contact surface for the midfoot ( p = 0.019). The latter was paralleled by higher maximum pressures at the midfoot ( p = 0.016). Patients reported a median score of 101 for the SF-36, 72 for the AOFAS midfoot score, and 7 for the VAS. Conclusion: Plantar pressure measurements showed an adjusted walking pattern. Despite a fair outcome score, the quality for life of patients following a Lisfranc fracture dislocation returned to normal compared with normative data for the general population. Level of Evidence: IV, Retrospective Case Control Series
Magnetic Resonance Imaging in Plantar Heel Pain
Authors: Chimutengwende-Gordon Mukai , O'Donnell Paul , Singh Dishan 
Published: October 2010

Background: Magnetic Resonance Imaging (MRI) is generally only indicated in patients with plantar heel pain who have atypical symptoms or who do not improve with appropriate management. Methods and Materials: This study retrospectively reviewed the MRI findings of 112 patients with heel pain divided into two groups consisting of 50 patients with persistent pain despite appropriate treatment and 62 patients with atypical heel pain. Results: Of the 50 patients with persistent heel pain, 38 (76%) of MRIs confirmed the diagnosis of plantar fasciitis. Of the 62 patients who had presented with atypical symptoms or signs, 21 patients had presented with night pain and the remaining 41 had presented with acute pain, tenderness of the lateral or medial aspect of the heel, significant swelling, neurological features or pain posterior to the insertion of the plantar fascia. Patients with night pain were shown to have plantar fasciitis associated with calcaneal marrow edema in 15 (71.4%) cases ( p < 0.05). One patient presenting with night pain was found to have a plantar arterio-venous malformation. Acute pain was associated with plantar fascia tears in 4 out of 9 ( p < 0.05). Conclusion: MRI may provide reassurance in cases of persistent heel pain but rarely changes the management. In cases of atypical heel pain, MRI may demonstrate other pathology such as plantar fascia tearing, calcaneal edema or arteriovenous malformation. Level of Evidence: IV, Retrospective Case Series
Clinical Relevance of Hindfoot Alignment View in Total Ankle Replacement
Authors: Frigg Arno , Nigg Benno , Hinz Laura , Valderrabano Victor , Russell Iain 
Published: October 2010

Background: Alignment is instrumental for success and long-term survival of Total Ankle Replacement (TAR). At this point in TAR, only coronal alignment in the region of the tibiotalar joint or above has been assessed because inframalleolar deformity is difficult to visualize radiographically. The Hindfoot Alignment View (HAV) allows visualization of the hindfoot position relative to the tibia. The purpose of this study was to evaluate the clinical relevance of this view in assessing patients with TAR. Materials and Methods: Twenty-eight consecutive patients with a Hintegra-TAR with an average followup of 4.1 ± 1.5 years were followed with (1) AOFAS and SF-36 scores, (2) visual judgment of the hindfoot position, (3) HAV and AP/lateral radiographs, (4) dynamic pedobarography (Novel emed m/E, Munich, Germany). Results: The HAV position correlated well with different load parameters on heel strike ( r = 0.44 to 0.62) but not with the varus-valgus load pattern of the rest of the foot. Visual judgment and TAR joint line did not correlate to radiographic hindfoot alignment or to pedobarographic load distribution. The hindfoot alignment measured by the HAV correlated significantly to the Physical Function and Role Physical of SF-36. No correlation was found to other SF36-qualities or the AOFAS-score. Conclusion: Inframalleolar alignment, as assessed by the HAV, influenced the dynamic pedobarographic load pattern and clinical outcome. Visual judgment and TAR joint line were not accurate enough to estimate the hindfoot alignment or dynamic load pattern. We believe adjusting the hindfoot correctly with HAV might improve long-term outcome and survival of TAR. Level of Evidence: IV, Retrospective Case Series
Reliability of the Maestro Radiographic Measuring Tool
Authors: Deleu Paul-André , Leemrijse Thibaut , Birch Ivan , Berg Bruno Vande , Bevernage Bernhard Devos 
Published: October 2010

Introduction: Maestro et al. presented a detailed preoperative measuring and classification technique for the forefoot. The purpose of this paper was to determine if the PACS system will allow the Maestro measuring technique and classification system to be reliable and precise. Materials and Methods: This radiographic study was conducted on 73 subjects (36 females, 37 males, age 30.4 ± 9.9) who had given informed consent. The geometrical progression was measured for each foot of each subject by the two observers according to the measuring methodology of Maestro. The intraclass correlation coefficient (ICC), and the 95% lower confidence limit (95% LCL) were calculated for the geometrical progression variables of the lesser metatarsals. Once the feet were classified by each observer, the accordance in classification of the feet was analyzed between the two observers. Results: The radiographic measuring technique of Maestro was a reliable method for analyzing the mathematical progression of the lesser metatarsals through the use of the PACS system. A 92.6% concordance in the classification of the radiological forefoot morphotypes was found between the two observers. Conclusion: We found Maestro et al.'s measuring technique and classification system precise and reproducible using PACS digital radiographs. It is hoped that utilization of this technique will lead to better forefoot outcomes and patient satisfaction. Level of Evidence: IV, Case Series
Evolution of Avian Conservation Breeding With Insights for Addressing the Current Extinction Crisis
Authors: D'Elia Jesse 
Published: October 2010

AbstractBirds have been bred in captivity since the dawn of civilization. In the nineteenth century, breeding rare and exotic animals for the menageries of royalty and aristocrats transitioned to the formation of public zoological gardens and natural history museums. With industrialization and human population expansion, some bird species became rare or disappeared entirely. Once the magnitude of the destructive forces of humans became evident, concerted efforts were initiated to restore depleted bird populations by using, among other techniques, captive breeding. In this article, I explore the evolution of avian conservation breeding programs and evaluate how this historical review informs our outlook for addressing the current extinction crisis.
An Inflammasome-Independent Role for Epithelial-Expressed Nlrp3 in Renal Ischemia-Reperfusion Injury
Authors: Shigeoka Alana A. , Mueller James L. , Kambo Amanpreet , Mathison John C. , King Andrew J. , Hall Wesley F. , Correia Jean da Silva , Ulevitch Richard J. , Hoffman Hal M. , McKay Dianne B. 
Published: October 2010

Abstract
Cytoplasmic innate immune receptors are important therapeutic targets for diseases associated with overproduction of proinflammatory cytokines. One cytoplasmic receptor complex, the Nlrp3 inflammasome, responds to an extensive array of molecules associated with cellular stress. Under normal conditions, Nlrp3 is autorepressed, but in the presence of its ligands, it oligomerizes, recruits apoptosis-associated speck-like protein containing a caspase recruitment domain (Asc), and triggers caspase 1 activation and the maturation of proinflammatory cytokines such as IL-1β and IL-18. Because ischemic tissue injury provides a potential source for Nlrp3 ligands, our study compared and contrasted the effects of renal ischemia in wild-type mice and mice deficient in components of the Nlrp3 inflammasome (Nlrp3−/− and Asc−/− mice). To examine the role of the inflammasome in renal ischemia-reperfusion injury (IRI) we also tested its downstream targets caspase 1, IL-1β, and IL-18. Both Nlrp3 and Asc were highly expressed in renal tubular epithelium of humans and mice, and the absence of Nlrp3, but not Asc or the downstream inflammasome targets, dramatically protected from kidney IRI. We conclude that Nlrp3 contributes to renal IRI by a direct effect on renal tubular epithelium and that this effect is independent of inflammasome-induced proinflammatory cytokine production.
Primary Recrystallization of Invar, Fe‐36%Ni Alloy: Origin and Development of the Cubic Texture
Authors: Penelle Richard , Baudin Thierry 
Published: October 2010

AbstractThis short review summarizes the main results acquired by Penelle's group at the Université Paris Sud 11 in Orsay during the last 10 years on recrystallization of the Fe‐36%Ni so‐called Invar alloy. The formation and the development of the cube texture after high deformation by cold rolling (CR) and subsequent annealing is interpreted from a multiscale analysis based on TEM, SEM/EBSD, X‐ray, and neutron diffraction measurements coupled with a Monte Carlo simulation. It is shown that the cube orientation which presents a cellular deformation substructure consumes the noncube matrix. This is interpreted by the high difference of stored deformation energy between the cube and the recovered matrix which is the main driving force for recrystallization. The parameters disorientation and subgrain size are also discussed. For low CR reductions, the difference of stored energy is weaker and as a consequence other orientations of the matrix have time to develop which leads to a softening of the recrystallization texture, the texture randomization is intensified by annealing twinning.
Organic FETs: Functional Organic Field‐Effect Transistors (Adv. Mater. 40/2010)
Authors: Guo Yunlong , Yu Gui , Liu Yunqi 
Published: October 2010

AbstractFunctional organic field‐effect transistors (OFETs) have attracted increasing attention in the past few years due to their wide variety of potential applications. Research on functional OFETs underpins future advances in organic electronics. In this review, different types of functional OFETs including organic phototransistors, organic memory FETs, organic light emitting FETs, sensors based on OFETs and other functional OFETs are introduced. In order to provide a comprehensive overview of this field, the history, current status of research, main challenges and prospects for functional OFETs are all discussed
Synthesis of hybrid polyaniline/carbon nanotube nanocomposites by dynamic interfacial inverse emulsion polymerization under sonication
Authors: Suckeveriene R. Y. , Zelikman E. , Mechrez G. , Tzur A. , Frisman I. , Cohen Y. , Narkis M. 
Published: October 2010

AbstractThis article describes an ultrasonically assisted in situ interfacial dynamic inverse emulsion polymerization process of aniline in the presence of multiwalled carbon nanotubes (MWNT) in chloroform. During polymerization, MWNT are coated with polyaniline (PANI) forming a core‐shell structure of nanowires, as evidenced by cryogenic transmission electron microscopy. Thermogravimetric analysis curves and conversion measurements provided important knowledge regarding the unique polymerization method. Scanning electron microscopy images and surface resistivity imply that PANI/MWNTs are characterized by a structural synergistic effect. The PANI coating of MWNT leads to a remarkable improvement in separation and dispersion of MWNT in chloroform, which otherwise would rapidly coagulate and settle. The presented interfacial dynamic polymerization process is very fast, reaching 82% conversion within 5 min of sonication and produces stable clear dispersions of doped PANI in chloroform. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Spatial variation in abundance and diversity of the smaller surface and near‐surface eelgrass‐associated intertidal macrobenthos within a warm‐temperate estuarine bay in the Garden Route National Park, RSA
Authors: Barnes R. S. K. 
Published: October 2010

Abstract
Smaller members (<10 mm) of the sediment‐surface macrobenthos of Nanozostera capensis meadows across 9 km2 of the marine Outer Basin of the Knysna estuarine bay (Garden Route National Park, Western Cape, South Africa) were investigated at a series of 24 stations.
Ordination (nMDS) disclosed the existence of five clusters of stations related to degree of exposure. Relatively sheltered stations were dominated by two endemic species of deposit‐feeding microgastropod, and they supported significantly higher macrobenthic densities but lower species diversity and less evenness than relatively exposed stations. The latter were dominated by polychaetes and also possessed more suspension feeders, equivalent to more open seagrass beds in other latitudes. Species richness per station, however, was relatively constant across the whole basin.
The smaller benthic macrofauna, totalling 82 species, was found to include several animals (<5 mm) hitherto unknown from the region, including one gastropod genus (Cornirostra) not previously known from Africa.
Species were patchily distributed across all scales from 1 m to >1 km, but variance partitioning showed components of total variance to decrease with increasing spatial scale: sample (46.5%), station (30.0%), site (23.5%).
These findings are discussed in relation to conservation site selection in rich but faunistically heterogeneous seagrass beds that are impacted by bait collection or other human disturbance. Copyright © 2010 John Wiley & Sons, Ltd.
Selective ERK activation differentiates mouse and human tolerogenic dendritic cells, expands antigen‐specific regulatory T cells, and suppresses experimental inflammatory arthritis
Authors: Arce Frederick , Breckpot Karine , Stephenson Holly , Karwacz Katarzyna , Ehrenstein Michael R. , Collins Mary , Escors David 
Published: October 2010

AbstractObjectiveMost therapeutic treatments for autoimmune arthritis rely on immunosuppressive drugs, which have side effects. Although a previous study by our group showed that specific ERK activation suppressed immune responses, its application in a therapeutic setting has never been tested. The aim of the present study was to define the ERK‐dependent immunosuppressive mechanisms and to apply selective ERK activation for the treatment of experimental inflammatory arthritis.MethodsA constitutively active ERK activator was coexpressed with a model antigen using lentivectors. Immunosuppressive mechanisms were characterized at the level of dendritic cell (DC) function, differentiation of antigen‐specific Treg cells, and inhibition of inflammatory T cells. Administration of the ERK activator with antigen as a strategy to suppress inflammatory arthritis was tested in an experimental mouse model.ResultsSelective ERK activation induced mouse and human DCs to secrete bioactive transforming growth factor β, a process required for suppression of T cell responses and differentiation of antigen‐specific Treg cells. Treg cells strongly proliferated after antigen reencounter in inflammatory conditions, and these cells exhibited antigen‐dependent suppressive activities. Inflammatory arthritis was effectively inhibited through antigen‐specific mechanisms. Importantly, this strategy did not rely on identification of the initiating arthritogenic antigen. Equivalent mechanisms were demonstrated in human monocyte–derived DCs, setting the scene for a possible rapid translation of this approach to patients with rheumatoid arthritis.ConclusionThis strategy of selective ERK activation resulted in an effective therapeutic protocol, with substantial advantages over DC or T cell vaccination.
Classification of rheumatoid arthritis: Comparison of the 1987 American College of Rheumatology criteria and the 2010 American College of Rheumatology/European League Against Rheumatism criteria
Authors: van der Linden M. P. M. , Knevel R. , Huizinga T. W. J. , van der Helm‐van Mil A. H. M 
Published: October 2010

AbstractObjectiveNew criteria to classify rheumatoid arthritis (RA) have been derived in order to increase the specificity and sensitivity for early RA compared with the 1987 American College of Rheumatology (ACR) criteria. The aim of this study was to evaluate differences in classification between the 1987 ACR criteria and the 2010 ACR/European League Against Rheumatism (EULAR) criteria in an early arthritis cohort and to determine the test characteristics of the 2010 ACR/EULAR criteria.MethodsA total of 2,258 patients with early arthritis included in the Leiden Early Arthritis Clinic cohort were studied. Fulfillment of the 1987 and 2010 criteria for the classification of RA was determined at baseline. The diagnosis of each patient at 1 year was assessed. The sensitivity and specificity of the 2010 criteria were determined using the following outcome measures: initiation of methotrexate therapy or any disease‐modifying antirheumatic drug (DMARD) therapy during the first year of followup and having persistent arthritis during 5 years of followup.ResultsAt their first presentation, 1,099 patients fulfilled the 2010 criteria, and 726 patients fulfilled the 1987 criteria for RA. Eighty‐two of the 726 patients fulfilling the 1987 criteria did not fulfill the 2010 criteria. Sixty‐eight percent of the patients who fulfilled the 1987 criteria during the first year of disease but not at baseline did fulfill the 2010 criteria at baseline. In 18% of patients, use of the 2010 classification criteria also led to a revoked classification at 1 year. The sensitivity and specificity of the 2010 criteria were 0.84 and 0.60, respectively, with methotrexate therapy as the outcome and 0.74 and 0.74, respectively, with DMARD therapy as the outcome. With persistent arthritis as the outcome, the sensitivity and specificity of the 2010 criteria were 0.71 and 0.65, respectively.ConclusionCompared with the 1987 criteria, the 2010 criteria classify more patients with RA and at an earlier phase of the disease. The discriminative ability of the 2010 criteria is acceptable.
A genetic variation located in the promoter region of the UPAR (CD87) gene is associated with the vascular complications of systemic sclerosis
Authors: Manetti Mirko , Allanore Yannick , Revillod Lucile , Fatini Cinzia , Guiducci Serena , Cuomo Giovanna , Bonino Claudia , Riccieri Valeria , Bazzichi Laura , Liakouli Vasiliki , Cipriani Paola , Giacomelli Roberto , Abbate Rosanna , Bombardieri Stefano , Valesini Guido , Montecucco Carlomaurizio , Valentini Gabriele , Ibba‐Manneschi Lidia , Matucci‐Cerinic Marco 
Published: October 2010

AbstractObjectiveThe UPAR gene encodes a pleiotropic receptor (urokinase‐type plasminogen activator receptor [uPAR]) involved in fibrosis, immunity, angiogenesis, and vascular remodeling. Previous studies have implicated uPAR in systemic sclerosis (SSc) vasculopathy and impaired angiogenesis. We undertook this study to investigate whether UPAR gene promoter polymorphisms might be associated with SSc phenotypes in the European Caucasian population.MethodsWe studied a total population of 1,339 individuals. The Italian discovery cohort comprised 388 SSc patients and 391 healthy controls. The French replication cohort consisted of 344 SSc patients and 216 healthy controls. The UPAR rs344781 and rs4251805 single‐nucleotide polymorphisms were genotyped by polymerase chain reaction–restriction fragment length polymorphism assay.ResultsIn the Italian cohort, the rs344781 G allele was associated with SSc‐related digital ulceration (odds ratio [OR] 1.39), pulmonary arterial hypertension (PAH) (OR 1.81), anticentromere antibody (ACA) positivity (OR 1.45), and limited cutaneous SSc (lcSSc) (OR 1.37). The rs344781 GG genotype was associated with SSc‐related (OR 3.79), ACA‐positive SSc (OR 2.17), and lcSSc (OR 1.96). Allelic and genotypic associations with SSc‐related digital ulceration and ACA‐positive SSc were replicated in the French sample. Combined analyses showed an association of the rs344781 G allele and GG genotype with SSc‐related digital ulceration (allele OR 1.41, genotype OR 2.15), SSc‐related PAH (allele OR 1.65, genotype OR 3.16), ACA‐positive SSc (allele OR 1.47, genotype OR 2.40), and lcSSc (allele OR 1.34, genotype OR 1.77). In a multivariate logistic regression analysis model including the above associated phenotypes of SSc patients, the rs344781 GG genotype remained an independent risk factor for SSc‐related digital ulceration (OR 1.96) and SSc‐related PAH (OR 2.68).ConclusionThe UPAR rs344781 gene variant is associated with the SSc vascular phenotype.
Ablation of the Ccr2 gene exacerbates polyarthritis in interleukin‐1 receptor antagonist–deficient mice
Authors: Fujii Hiroshi , Baba Tomohisa , Ishida Yuko , Kondo Toshikazu , Yamagishi Masakazu , Kawano Mitsuhiro , Mukaida Naofumi 
Published: October 2010

AbstractObjectiveThe pathogenesis of rheumatoid arthritis (RA) involves cytokines and chemokines. Given the role of intraarticular macrophage infiltration in RA, this study was undertaken to address the pathogenic role of CCR2, a chemokine receptor that is abundantly expressed by macrophages, in Il1rn‐deficient mice, a mouse model of RA.MethodsIl1rn‐deficient and Il1rn and Ccr2–double‐deficient mice were subjected to clinical assessment of arthritis and histologic examination. Bone mineral density was measured with computed tomography. The types of cells infiltrating joints were determined by immunohistochemical analysis and flow cytometric analysis. Osteoclasts in joints were quantified after tartrate‐resistant acid phosphatase staining. Cytokine and chemokine levels were measured by enzyme‐linked immunosorbent assay and multiplex suspension array assay. The expression patterns of chemokines and osteoclastogenic factors were determined by double‐color immunofluorescence analysis. Anti‐mouse CXCR2 antibody was injected into Il1rn and Ccr2–double‐deficient mice for blocking experiments.ResultsAblation of the Ccr2 gene actually exacerbated arthritis and intraarticular osteoclastogenesis, while it enhanced intraarticular neutrophil but not macrophage accumulation in Il1rn‐deficient mice. Infiltrated neutrophils expressed the osteoclastogenic factors RANKL and ADAM‐8, thereby augmenting intraarticular osteoclastogenesis in Il1rn and Ccr2–double‐deficient mice. Moreover, the double‐deficient mice exhibited enhanced expression of the neutrophilic chemokines keratinocyte chemoattractant and macrophage inflammatory protein 2 (MIP‐2), compared with Il1rn‐deficient mice. Finally, neutralizing antibodies to CXCR2, the receptor for keratinocyte chemoattractant and MIP‐2, dramatically attenuated arthritis in Il1rn and Ccr2–double‐deficient mice.ConclusionOur findings indicate that CCR2‐mediated signals can modulate arthritis in Il1rn‐deficient mice by negatively regulating neutrophil infiltration.