bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Regioselective Addition of Thiophenol to α,β‐Unsaturated N‐Acylbenzotriazoles.
Authors: Xia Ziming , Lv Xin , Wang Wencun , Wang Xiaoxia 
Published: December 2011

AbstractDepending on the additive (ZnCl2 or silica gel) and the reaction temperature, different types of addition products can be obtained.
ChemInform Abstract: Carbon—Sulfur Coupling Reactions Catalyzed by Pd—NHC Complex.
Authors: Shi Yanhui , Cai Zhengyuan , Guan Pei , Pang Guangsheng 
Published: December 2011

AbstractA monoligated Pd‐complex is shown to be an excellent precursor for a NHC catalyst to improve the C—S coupling of various aryl halides with thiophenol and benzyl mercaptan.
ChemInform Abstract: Catalytic, Asymmetric Hypervinylogous Mukaiyama Aldol Reactions of Extended Furan‐Based Silyl Enolates.
Authors: Curti Claudio , Battistini Lucia , Sartori Andrea , Lodola Alessio , Mor Marco , Rassu Gloria , Pelosi Giorgio , Zanardi Franca , Casiraghi Giovanni 
Published: December 2011

AbstractIt is found that Denmark′s bisphosphoramide efficiently promotes the title reaction and allows formation of various γ‐alkylidene butenolide carbinols with complete ω‐site selectivity and good to excellent enantioselectivity.
ChemInform Abstract: Umpolung Reactivity of Indole Through Gold Catalysis.
Authors: Lu Biao , Luo Yingdong , Liu Lianzhu , Ye Longwu , Wang Yanzhao , Zhang Liming 
Published: December 2011

AbstractCyclization of ortho‐azido arylalkynes generates intermediate indole complexes with an Umpolung reactivity of the 3‐position.
ChemInform Abstract: Organocatalyzed Enantioselective Fluorocyclizations.
Authors: Lozano Oscar , Blessley George , Martinez del Campo Teresa , Thompson Amber L. , Giuffredi Guy T. , Bettati Michela , Walker Matthew , Borman Richard , Gouverneur Veronique 
Published: December 2011

AbstractTwo different halogenation procedures including both (DHQ)2‐PHAL as the enantioselective agent are developed for the preparation of fluorinated heterocyclic scaffolds which are obtained as exclusive cis isomers.
ChemInform Abstract: Synthesis and Antihyperlipidemic Activity of Some Novel 4‐(Substitutedamino)‐5‐substituted‐3‐mercapto‐(4H)‐1,2,4‐triazoles.
Authors: Chhabria Mahesh T. , Suhagia Bhanubhai N. , Brahmkshatriya Pathik S. , Raval Priyesha M. 
Published: December 2011

AbstractA variety of novel mercaptotriazoles [cf.
ChemInform Abstract: Discovery of New Photoactivatable Diaryltetrazoles for Photoclick Chemistry via “Scaffold Hopping”.
Authors: Yu Zhipeng , Ho Lok Yin , Wang Zhiyong , Lin Qing 
Published: December 2011

AbstractFive diaryltetrazoles are prepared by using the Kakehi procedure, followed by elaboration of the side chains in most of the cases.
ChemInform Abstract: Synthesis of Methyl 3‐Acyl‐6‐amino‐5‐cyano‐4‐phenyl‐4H‐pyran‐2‐carboxylates and Their Rearrangement into 2‐Hydroxy‐4‐ [hydroxy(R)methylidene]‐3‐oxo‐5‐phenylcyclopent‐1‐ene‐1‐carbonitriles.
Authors: Sheverdov V. P. , Nasakin O. E. , Andreev A. Yu. , Gein V. L. , Tafeenko V. A. 
Published: December 2011

AbstractA simple and convenient synthesis of the compounds (IV) is presented.
ChemInform Abstract: Palladium‐Catalyzed Cyclization of α‐Hydroxy Allylic Acetates: A Formal Synthesis of (.+‐.)‐Swainsonine.
Authors: Bates Roderick W. , Dewey Mark R. , Tang Chi H. , Safii Shahidah bte , Hong Yanhan , Hsieh Jolyn Ke Hui , Siah Pei Shan 
Published: December 2011

AbstractThe Pd‐catalyzed cyclization of allylic acetate (I) is directed by the OH group to give a trans‐substituted piperidine.
ChemInform Abstract: Microwave‐Assisted Synthesis of Quinoxalines in PEG‐400.
Authors: Zhang Xia‐Zhong , Wang Jin‐Xian , Bai Lin 
Published: December 2011

AbstractA green and efficient method for the synthesis of quinoxaline derivatives (18 examples) by condensation of aryl‐1,2‐diamines with 1,2‐dicarbonyl compounds is developed.
ChemInform Abstract: 1,5‐Benzoheteroazepines Through Eco‐Friendly General Condensation Reactions.
Authors: Nardi Monica , Cozza Annalisa , Maiuolo Loredana , Oliverio Manuela , Procopio Antonio 
Published: December 2011

AbstractThe presence of Er(OTf)3 allows the synthesis of various heterocyclic ring systems.
ChemInform Abstract: Synthesis of Rare Sugars with L‐Fuculose‐1‐phosphate Aldolase (FucA) from Thermus thermophilus HB8.
Authors: Li Zijie , Cai Li , Qi Qingsheng , Styslinger Thomas J. , Zhao Guohui , Wang Peng George 
Published: December 2011

AbstractA one‐pot, four‐enzyme approach yields the rare sugars (D)‐psicose (III), (D)‐sorbose (IV), (L)‐tagatose, and (L)‐fructose in the presence of the thermophilic source‐derived title aldolase as the catalyst.
ChemInform Abstract: Functionalization of Heterocyclic Compounds Using Polyfunctional Magnesium and Zinc Reagents
Authors: Knochel Paul , Schade Matthias A. , Bernhardt Sebastian , Manolikakes Georg , Metzger Albrecht , Piller Fabian M. , Rohbogner Christoph J. , Mosrin Marc 
Published: December 2011

AbstractReview: 60 refs.
ChemInform Abstract: Biologically Active Cyclic Polypeptides with Fragments of β‐Amino Acid Derivatives Isolated from Marine Organisms
Authors: Romanova N. N. , Tallo T. G. , Rybalko I. I. , Zyk N. V. , Shvyadas V. K. 
Published: December 2011

AbstractReview: structure, stereochemistry, bioactivity; 63 refs.
Microporous PVC – New Membrane Material for Application in Microfiltration
Authors: Trommer Kristin , Palitzsch Wolfram , Morgenstern Bernd , Loser Ulrich 
Published: December 2011

AbstractDie Membranfiltration ist ein etabliertes Verfahren für die Aufbereitung von industriellen Abwässern sowie von Prozesschemikalien. Allerdings stellt die Abtrennung von Partikeln und Kolloiden aus chemisch aggressiven Medien für die verwendeten Materialien nach wie vor eine Herausforderung dar. Speziell für Trennprobleme im Bereich stark saurer oder stark basischer, heißer Lösungen wurde unter Ausnutzung der Chemikalienbeständigkeit des Kunststoffes PVC eine neuartige Filtermembran entwickelt. Die mikroporöse PVC‐Membran ist in kontinuierlicher Weise von Rolle zu Rolle auf etablierten Anlagen zur Polymerverarbeitung herstellbar.
Cortical projections to the superior colliculus in prosimian galagos (Otolemur garnetti)
Authors: Baldwin Mary K.L , Kaas Jon H. 
Published: December 2011

AbstractThe superior colliculus (SC) is a key structure within the extrageniculate pathway of visual information to cortex and is highly involved in visuomotor functions. Previous studies in anthropoid primates have shown that superficial layers of the SC receive direct inputs from various visual cortical areas such as V1, V2, and middle temporal (MT), while deeper layers receive direct inputs from visuomotor cortical areas within the posterior parietal cortex and the frontal eye fields. Very little is known, however, about the corticotectal projections in prosimian primates. In the current study we investigated the sources of cortical inputs to the SC in prosimian galagos (Otolemur garnetti) using retrograde anatomical tracers placed into the SC. The superficial layers of the SC in galagos received the majority of their inputs from early visual areas and visual areas within the MT complex. Yet, surprisingly, MT itself had relatively few corticotectal projections. Deeper layers of the SC received direct projections from visuomotor areas including the posterior parietal cortex and premotor cortex. However, relatively few corticotectal projections originated within the frontal eye fields. While prosimian galagos resemble other primates in having early visual areas project to the superficial layers of the SC, with higher visuomotor regions projecting to deeper layers, the results suggest that MT and frontal eye field projections to the SC were sparse in early primates, remained sparse in present‐day prosimian primates, and became more pronounced in anthropoid primates. J. Comp. Neurol. 520:2002–2020, 2012. © 2011 Wiley Periodicals, Inc.
Kisspeptin expression in guinea pig hypothalamus: Effects of 17β‐estradiol
Authors: Bosch Martha A. , Xue Changhui , Rønnekleiv Oline K. 
Published: December 2011

AbstractKisspeptin is essential for reproductive functions in humans. As a model for the human we have used the female guinea pig, which has a long ovulatory cycle similar to that of primates. Initially, we cloned a guinea pig kisspeptin cDNA sequence and subsequently explored the distribution and 17β‐estradiol (E2) regulation of kisspeptin mRNA (Kiss1) and protein (kisspeptin) by using in situ hybridization, real‐time PCR and immunocytochemistry. In ovariectomized females, Kiss1 neurons were scattered throughout the preoptic periventricular areas (PV), but the vast majority of Kiss1 neurons were localized in the arcuate nucleus (Arc). An E2 treatment that first inhibits (negative feedback) and then augments (positive feedback) serum luteinizing hormone (LH) increased Kiss1 mRNA density and number of cells expressing Kiss1 in the PV at both time points. Within the Arc, Kiss1 mRNA density was reduced at both time points. Quantitative real‐time PCR confirmed the in situ hybridization results during positive feedback. E2 reduced the number of immunoreactive kisspeptin cells in the PV at both time points, perhaps an indication of increased release. Within the Arc, the kisspeptin immunoreactivity was decreased during negative feedback but increased during positive feedback. Therefore, it appears that in guinea pig both the PV and the Arc kisspeptin neurons act cooperatively to excite gonadotropin‐releasing hormone (GnRH) neurons during positive feedback. We conclude that E2 regulation of negative and positive feedback may reflect a complex interaction of the kisspeptin circuitry, and both the PV and the Arc respond to hormone signals to encode excitation of GnRH neurons during the ovulatory cycle. Comp. Neurol. 520:2143–2162, 2012. © 2011 Wiley Periodicals, Inc.
Enabling hierarchical dissemination of streams in content distribution networks
Authors: Pallickara Shrideep , Fox Geoffrey 
Published: December 2011

SUMMARYIn streaming systems the content distribution network routes streams based on interests registered by the consuming entities. In hierarchical streaming, the dissemination is also predicated on the resolution of hierarchical dependencies between various streams. Entities specify explicit wildcards, in addition to the implicit ones in place, to further control the types of streams within a given hierarchy that should be routed to them. This paper presents an analysis and performance evaluation of three different algorithms for hierarchical streaming. In our evaluation of these algorithms we are especially interested in three factors: performance, ability to cope with flux, and memory consumption. Comprehensive benchmarks for these algorithms, in this paper, will enable system designers to harness the best algorithm that satisfies their hierarchical streaming requirements. Copyright © 2011 John Wiley & Sons, Ltd.
Microstructure and cathodoluminescence study of GaN nanowires without/with P‐doping
Authors: Liu Baodan , Hu Tao , Wang Zaien , Liu Lizhao , Qin Fuwen , Huang Nan , Jiang Xin 
Published: December 2011

AbstractIn this work, P‐doped GaN nanowires were synthesized in a co‐deposition CVD process and the effects of P‐doping on the microstructure and cathodoluminescence (CL) of GaN nanowires were studied in details. SEM observation and CL measurments demonstrated that P‐doping has led to a rough morphology evolution and a depression of the band‐gap emission of GaN nanowires, whereas the visible emission of GaN nanowires was obviously enhanced. Finally, the corresponding morphology transition and optical properties of GaN nanowires with P‐doping were discussed. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Conformality Investigation of Titanium Dioxide Thin Films on 3‐D Micrometer‐ and Nanometer‐scale Features by Pulsed‐Pressure Metal‐organic CVD
Authors: Siriwongrungson Vilailuck , Krumdieck Susan P. , Alkaisi Maan M. 
Published: December 2011

AbstractThe influence of the processing parameters on conformality is studied for pulsed‐pressure (PP) metal‐organic (MO)CVD. A statistical method to measure conformality, and a model for pulse vapor exposure are presented. Titanium dioxide (TiO2) thin films are deposited from a liquid titanium isopropoxide (TTIP, Ti(OPr)4) solution with no carrier gas on silicon and silicon nitride substrates with 3‐D micrometer‐ and nanometer‐scale structures. The deposited films are columnar anatase TiO2 with thicknesses between 130 nm and 310 nm, controlled by the number of pulses. The statistical conformality varies from 0.81 to 0.93, decreased slightly with increasing deposition temperature, and is insensitive to pulse exposure.
A Ballistic Transport and Surface Reaction Model for Simulating Atomic Layer Deposition Processes in High‐Aspect‐Ratio Nanopores
Authors: Adomaitis Raymond A. 
Published: December 2011

AbstractIn this paper we develop a model describing the ballistic transport of chemical precursor species for an atomic layer deposition (ALD) process. In the application we consider, pore geometry or surface properties of nanoporous materials are modified using ALD, taking advantage of its potential for conformal deposition in high‐aspect‐ratio structures. Because of the very large Knudsen number corresponding to these processes, the transport of gas‐phase species inside the nanostructures takes place in a purely ballistic manner. Precursor transmission probability functions describing the fluxes between the pore surface features are developed and compared to previously published results. The transport model elements are then coupled to ALD surface‐reaction models, spatially discretized, and integrated over each precursor exposure period to determine the pore spatial surface reaction extent profile. Predictions from our dynamic model are then compared to four previously published studies of ALD in nanopores to validate our simulator, and to gain further insight into the physical mechanisms at work in ALD processes. The utility of physically based models of the type we develop can be exploited to determine optimal precursor exposure levels for ALD‐based nanomanufacturing operations.
CD300a is expressed on human basophils and seems to inhibit IgE/FcεRI‐dependent anaphylactic degranulation
Authors: Sabato Vito , Verweij Marjoke M. , Bridts Chris H. , Levi‐Schaffer Francesca , Gibbs Bernhard F. , De Clerck Luc S. , Schiavino Domenico , Ebo Didier G. 
Published: December 2011

AbstractBackground.The final response that leads to basophil degranulation results from a cross‐talk between activatory and inhibitory signals. However, in the context of basophil biology, the inhibitory mechanisms that control these processes are still poorly understood.Aim.To investigate the expression and function of the inhibitory receptor CD300a in human basophils.Methods.Peripheral blood of 20 patients with birch pollen allergy and 10 healthy control individuals were assessed for CD300a expression before and after activation. To study the function of CD300a, basophils were pre‐incubated with anti‐human CD300a/c monoclonal antibodies and analyzed for the up‐regulation of the activation marker CD203c and appearance of the degranulation marker CD63 following IgE‐dependent and IgE‐independent triggering.Results.Basophils from allergic individuals constitutively expressed significantly less CD300a than non‐allergics (P = 0.001). However, after cross‐linking with either anti‐IgE or recombinant major birch pollen allergen (rBet v 1), basophils from allergic patients demonstrated a significant and rapid (3 min) up‐regulation of CD300a expression in all activated basophils that persisted for over 2 h (P < 0.05). Moreover, CD300a expression was significantly higher in the CD203cbright+CD63bright+ subpopulation than in CD203cbright+CD63− cells (P < 0.05). In both patients and controls, pre‐incubation with anti‐CD300a/c significantly inhibited IgE‐mediated CD63 expression (P < 0.05), though it did not affect CD203c. In contrast, IgE‐independent basophil activation was not inhibited by CD300a/c engagement.Conclusion.CD300a is expressed on human peripheral blood basophils and rapidly up‐regulated upon cross‐linking of IgE/FcεRI and suppresses anaphylactic degranulation. © 2011 International Clinical Cytometry Society
Differentiation of methoxybenzoylpiperazines (OMeBzPs) and methylenedioxybenzylpiperazines (MDBPs) By GC‐IRD and GC‐MS
Authors: Abdel‐Hay Karim M. , DeRuiter Jack , Randall Clark C. 
Published: December 2011

The designer drug 3,4‐methylenedioxybenzylpiperazine (3,4‐MDBP), its positional isomer 2,3‐methylenedioxybenzylpiperazine (2,3‐MDBP) and three regioisomeric ring‐substituted methoxybenzoylpiperazines (OMeBzPs) have identical elemental composition and no marked differences in their mass spectra with only the three methoxybenzoylpiperazine regioisomers showing one unique major fragment ion at m/z 152. Perfluoroacylation of the secondary amine nitrogen of these isomeric piperazines gave mass spectra with differences in the relative abundance of some fragment ions but did not alter the fragmentation pathway to provide unique ions for discrimination among these isomers. Exact mass determination using gas chromatography coupled to time‐of‐flight mass spectrometry (GC‐TOF‐MS) did not provide any discrimination among these compounds since the main fragment ions are of identical elemental composition.Gas chromatography coupled to infrared detection (GC‐IRD) provides direct confirmatory data for the identification of the carbonyl containing compounds and the differentiation of the psychoactive designer drug 3,4‐MDBP from its direct (2,3‐MDBP) and indirect (OMeBzPs) regioisomers. The mass spectra in combination with the vapour phase infrared spectra provide for specific confirmation of each of the isomeric piperazines. The underivatized and perfluoroacyl derivative forms of the five piperazines involved in this study were resolved on a stationary phase of 100% trifluoropropyl methyl polysiloxane (Rtx‐200). Copyright © 2011 John Wiley & Sons, Ltd.
C–H Bond Activation of Palladium Complexes That Feature Pendant Benzamidinate Ligands and Their Catalytic Behaviours
Authors: Chen Ming‐Tsz , Wu Kai‐Min , Chen Chi‐Tien 
Published: December 2011

AbstractThe pendant benzamidines {Ph–C[=N–(2,6‐di‐iPr‐C6H3)](NHE)} [E = (CH2)2NMe2, CH2Py] and their palladium complexes [(Ph–C{=NE}{NH–(2,6‐di‐iPr‐C6H3)})Pd(OAc)2] [E = (CH2)2NMe2 (1), CH2Py (2)] have been prepared. Upon heating, the corresponding palladacyclic complexes, [({η1‐C6H4}–C(=NE){NH–(2,6‐di‐iPr‐C6H3)})PdOAc] [E = (CH2)2NMe2 (3), CH2Py (4)], were obtained. Due to the substituent groups on the ortho positions of the phenyl ring attached to the nitrogen atom of the amidinate group, the C–H bond activation process was observed on the ortho position of the phenyl ring attached to the carbon atom of the amidinate group. This process can be proved by X‐ray structural determination. The molecular structures are reported for compounds 1 and 4. Catalytic application of cyclopalladated derivatives 3 and 4 toward the Suzuki reaction was also investigated.
Titanium dioxide nanoparticles detoxify pirimicarb under UV irradiation at ambient intensities
Authors: Seitz Frank , Bundschuh Mirco , Dabrunz André , Bandow Nicole , Schaumann Gabriele E. , Schulz Ralf 
Published: December 2011

Abstract
Titanium dioxide nanoparticles (nTiO2) form reactive oxygen species (ROS) under irradiation by ultraviolet light (UV). This known photocatalytic activity may finally affect the presence and toxicity of organic environmental chemicals, which have not yet been studied at ambient UV intensity. The authors used a three-factorial design to evaluate the interaction of the carbamate insecticide pirimicarb (initial nominal concentration, 20 µg/L), ambient UV irradiation (40 W/m2 for 15 min), and nTiO2 (∼100 nm; 2.0 mg/L). Pirimicarb, pirimicarb × UV, and pirimicarb × nTiO2 treatments revealed a median immobilization of Daphnia magna after 72 h ranging between 70 and 80%. This effect seemed to be caused by the initial nominal pirimicarb concentration. However, UV irradiation before an exposure of daphnids in the presence of 2.0 mg nTiO2/L reduced pirimicarb concentrations to values below the limit of quantification, likely because of the formation of ROS. This reduction was associated with an almost complete removal of toxicity for D. magna. Furthermore, during a second experiment, 0.2 mg nTiO2/L in combination with 15 min UV irradiation reduced pirimicarb concentrations by approximately 30%. These results indicate a detoxification and therefore remediation potential of the combined application of nTiO2 and UV irradiation at ambient levels. This potential has not been documented to date in surface waters, where nTiO2 concentrations in the low to medium µg/L range may occur. Environ. Toxicol. Chem. 2012;31:518–523. © 2011 SETAC
The neoplastic impact of tobacco‐free betel‐quid on the histological type and the anatomical site of aerodigestive tract cancers
Authors: Lee Chien‐Hung , Lee Ka‐Wo , Fang Fu‐Min , Wu Deng‐Chyang , Tsai Shih‐Meng , Chen Ping‐Ho , Shieh Tien‐Yu , Chen Chung‐Ho , Wu I‐Chen , Huang Hsiao‐Ling , Chen Bai‐Hsiun , Chang Cheng‐Hsien , Chen Mu‐Kuan , Chou Shah‐Hwa , Tsai Yi‐Shan , Chiang Shang‐Lun , Ko Ying‐Chin 
Published: December 2011

AbstractLittle is known about any consequences of swallowing tobacco‐free betel‐quid (TF‐BQ) juice/remnants following chewing and its carcinogenic impact on the upper aerodigestive tract (UADT) to gastrointestinal tract (GIT). We investigated the neoplastic impact of TF‐BQ on different anatomical locations along UADT and GIT, and differences according to their histological categories. We conducted a multicenter case–control study examining patients with 2,163 pathology‐proven UADT and GIT cancers, comparing them with 2,250 control subjects. Generalized additive models, piecewise regression and polytomous logistic models were applied to identify possible dose‐dependent structures and cancer risks. Contrary to nonsignificant GIT‐adenocarcinoma risk (aOR = 0.9), TF‐BQ users experienced a 1.7‐ to 16.2‐fold higher risk of UADT‐squamous cell carcinomas than nonusers, with the peak risk discovered in oral neoplasms. We separately observed a curvilinear and linear TF‐BQ dose‐risk relationship in oral/pharyngeal/esophageal and laryngeal cancers. Chewers of betel inflorescence were generally at a greater UADT cancer risk. A higher first‐piecewise increased risk of esophageal cancer was recognized among areca‐fluid swallowers than among nonswallowers (continuous aOR = 1.12 vs. 1.03). TF‐BQ use accounted for 66.1–78.7% and 17.8–33.2% of the cases of oral/pharyngeal and esophageal/laryngeal cancers, respectively. However, a reduction from heavy TF‐BQ consumption to low‐to‐moderate consumption only reduced 11.3–34.6% of etiologic fraction of oral/pharyngeal cancers. Alcohol supra‐additively modified the risk of TF‐BQ in determining the development of oral, pharyngeal and esophageal cancers. In conclusion, the interplay of TF‐BQ and alcohol/tobacco use, combined with how chewing habit is practiced, influences carcinogenic consequences on anatomically diverse sites of UADT and GIT cancers, and histologically different types.