bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum perampanel levels in patients with seizures are not affected by hemodialysis
Authors: Nakazawa Yusuke , Shiraishi Wataru , Matsuyoshi Ayano , Inamori Yukiko , Mitani Koki , Ando Narutada , Shiomi Koji , Morita Takao , Koga Noriyuki , Agawa Yuji , Miyata Takeshi , Ogura Takenori , Hatano Taketo 
Published: June 2024

AbstractPerampanel belongs to a novel class of antiseizure medications (ASMs). Studies examining the effect of hemodialysis on perampanel serum levels in clinical settings are lacking. We aimed to evaluate the changes in serum perampanel levels during hemodialysis. We studied patients with seizures who received oral perampanel between April 2020 and March 2023 and whose serum concentration of perampanel was measured before and after hemodialysis. We analyzed the serum concentrations of levetiracetam and lacosamide for comparison. Fourteen patients, with a mean age of 76.1 ± 7.88 years, were included. The dose of perampanel was 2.14 ± 1.27 mg. The hemodialysis clearance rate of perampanel, levetiracetam, and lacosamide was 0 ± 13%, 69 ± 11%, and 59.6 ± 8.2%, respectively. The post‐dialysis CD ratio decreased significantly with levetiracetam but not with perampanel. Adverse but acceptable effects of perampanel were observed in two patients. The serum concentrations of several ASMs have been shown to be reduced during hemodialysis. Our study revealed that the serum perampanel concentration does not decrease during hemodialysis. Owing to the low rate of adverse effects and the stability of perampanel serum concentration during hemodialysis, perampanel could be a favorable choice as an ASM for patients with seizures undergoing hemodialysis.Plain Language summaryOur study looked at how hemodialysis affects the serum levels of perampanel, a new type of medication for seizures. In 14 patients who started treatment between April 2020 and March 2023, perampanel serum levels did not decrease during hemodialysis, unlike other seizure medications. This shows that perampanel can be a good option for patients with seizures who need hemodialysis, with fewer side effects compared to other medications.
The current pathogenicity and potential risk evaluation of Crimean‐Congo hemorrhagic fever virus to cause mysterious “Disease X”—An updated literature review
Authors: Jannath Sanjida , Islam Md. Rabiul 
Published: June 2024

AbstractBackground and AimsCrimean‐Congo hemorrhagic fever (CCHF) is a severe and potentially lethal illness. Tick bites of the Hyalomma genus are the primary source of transmission of CCHF to humans. The virus responsible for CCHF is the CCHF virus (CCHFV). It is a single‐stranded negative sensed RNA virus. The virus belongs to the Orthonairoviridae genus within the Nairoviridae family. It occurs in an extensive geographical area spanning the Middle East, western China, southern Asia, southeastern Europe, and much of Africa. The current study aimed to evaluate the pathogenicity and potential risk of CCHFV to cause a public health emergency of international concern.MethodsWe searched updated relevant information from PubMed, Google Scholar, and Scopus databases using Crimean‐Congo hemorrhagic fever, tick‐borne virus, and Nairovirus as keywords.ResultsThe case fatality rate (CFR) varies by region. It can be more than 30% in some cases. Three segments in the genome of CCHFV (L, M, and S) are different in size and function. It is unknown whether the pathogenicity of CCHFV varied based on the genomic diversity. CCHFV can be transmitted through tick bites, handling of infected ticks, contact with infected humans, contaminated body fluids, and so on. A wide range of severity is associated with CCHF, ranging from a moderate fever with no apparent cause to increased vascular permeability, failure of several organs, bleeding, and shock. Hospitals with high‐level isolation units should be the first choice for treating CCHF patients. Individual safety equipment is crucial in healthcare to prevent the spread of the virus. In the farm environment, using integrated pest management techniques, minimizing activity in tick‐infested regions, and dressing appropriately in long sleeves and pants will help to reduce the risk of CCHFV infection via tick bites.ConclusionThere are no approved vaccinations or therapeutics for CCHF except supportive therapeutic approaches. Therefore, scientists recommend early ribavirin therapy for cases of high‐risk exposures.
Reactivity of HLADR antibody manifests expression of surface MHC II molecules on peripheral blood T lymphocytes in new world monkeys
Authors: Chitta Sriram , Nehete Bharti P. , Delise Ashley B. , Simmons Joe H. , Nehete Pramod N. 
Published: June 2024

AbstractBackgroundMajor histocompatibility complex (MHC) class II molecules expressed on B cells, monocytes and dendritic cells present processed peptides to CD4+ T cells as one of the mechanisms to combat infection and inflammation.AimTo study MHC II expression in a variety of nonhuman primate species, including New World (NWM) squirrel monkeys (Saimiri boliviensis boliviensis), owl monkeys (Aotus nancymae), common marmosets (Callithrix spp.), and Old World (OWM) rhesus (Macaca mulatta), baboons (Papio anubis).MethodsTwo clones of cross‐reactive mouse anti‐human HLADR monoclonal antibodies (mAb) binding were analyzed by flow cytometry to evaluate MHC II expression on NHP immune cells, including T lymphocytes in whole blood (WB) and peripheral blood mononuclear cells (PBMC).ResultsMHC class II antibody reactivity is seen with CD20+ B cells, CD14+ monocytes and CD3+ T lymphocytes. Specific reactivity with both clones was demonstrated in T lymphocytes: this reactivity was not inhibited by purified CD16 antibody but was completely inhibited when pre‐blocked with purified unconjugated MHC II antibody. Freshly prepared PBMC also showed reactivity with T lymphocytes without any stimulation. Interestingly, peripheral blood from rhesus macaques and olive baboons (OWM) showed no such T lymphocyte associated MHCII antibody reactivity.Discussion & ConclusionOur results from antibody (MHC II) reactivity clearly show the potential existence of constitutively expressed (with no stimulation) MHC II molecules on T lymphocytes in new world monkeys. These results suggest that additional study is warranted to evaluate the functional and evolutionary significance of these finding and to better understand MHC II expression on T lymphocytes in new world monkeys.
A cross‐sectional study of academic success measures, grit, and resilience among US dental students
Authors: McKenzie Carly Timmons , Cruz Walma David Alexandre 
Published: June 2024

AbstractPurposeThis study explored themes previously identified as central to holistic professional school success, as related to traditional academic achievement, resilience, and grit measures.MethodsThis cross‐sectional study surveyed third‐ and fourth‐year US dental students. Items addressed themes previously identified as central to professional school success, including need for cognition, patient ownership, collective orientation, grit, and resilience. Traditional academic metrics were also included. Statistical analyses comprised one‐way analysis of variance (ANOVA), simple linear regression, and stepwise multiple regression procedures.ResultsA total of 126 students participated (81% response rate). Collective orientation, need for cognition, patient ownership, and resilience did not significantly correlate with grade point average (GPA), whereas grit did, r = 0.29. Need for cognition and patient ownership combined significantly predicted grit with approximately 35% of variance explained. Approximately 25% of variance in resilience scores was accounted for by need for cognition, coupled with collective orientation. Grit and resilience significantly correlated, r = 0.59.ConclusionsGrit significantly predicted both traditional and alternative metrics of success among dental students, particularly need for cognition and patient ownership. A high need for cognition is consistent among students who display both grit and resilience. Neither resilience nor the alternative measures of success predicted traditional academic metrics.
Dysregulation of miR‐146a in human milk of mothers having children with autism
Authors: Meguid Nagwa A. , Hemimi Maha , Rashad Mahmoud , Elsaeid Amal , Elpatrik Gina , Zeidan Hala M. 
Published: June 2024

AbstractAutism spectrum disorder (ASD) is a set of neurobehavioral manifestations that impose poor social interaction and stereotyped repetitive patterns. Several mircoRNA (miRNA) dysregulations underpin ASD pathophysiology via impairing the neurogenic niches. For instance, miR‐146a and miR‐106 differential expressions are linked to deregulation of ASD‐related genes and the severity of clinical symptoms, respectively. Breastfeeding provides newborns with many bioactive compounds that support their neurodevelopment including miRNA. Our pilot study evaluated the expression pattern of miR‐106a and miR‐146a in human milk (HM) of nursing mothers (n = 36) having autistic children compared to age‐matched counterparts (n = 36) with neurotypical children as controls. Under sterile conditions, breast milk samples were collected using manual sucking pumps and centrifuged to separate the fat layer. Total RNA was extracted from the lipid fraction, and the expression profiles of both miR‐106a and miR‐146a were evaluated using quantitative real‐time polymerase chain reaction. Among the test group, we reported some factors that were previously linked to HM miRNA perturbations: gestational diabetes, hypertension, and cesarean delivery. HM miR‐106a showed comparable expression levels in both mother groups (p = 0.8681), whereas HM miR‐146a was significantly downregulated in mothers with autistic children compared to controls (p = 0.0399). Alternatively, HM miR‐106 levels were positively associated with two ASD clinical parameters: Childhood Autism Rating Scale (CARS) and communication and language domain of Autism Diagnostic Interview‐Revised (ADI‐R) (r = 0.6452, p = 0.0003 and r = 0.3958, p = 0.0410, respectively). The receiver operating characteristic (ROC) curves of both maternal HM miR‐106a and miR‐146a showed poor fitness as predictive biomarkers for ASD. Our findings suggest that the miR‐146a differential expression in ASD children may originate at infancy during the lactation period. Thus, maternal pre‐ and postnatal health care is critical to maintain optimal miRNome in breast milk.
Vitamin B12: prevention of human beings from lethal diseases and its food application
Authors: Harikrishnan S , Kaushik Deepika , Kumar Mukul , Kaur Jasjit , Oz Emel , Proestos Charalampos , Elobeid Tahra , Karakullukcu Omur Fatih , Oz Fatih 
Published: June 2024

AbstractVitamin B12, a water‐soluble essential micronutrient, plays a pivotal role in numerous physiological processes in the human body. This review meticulously examines the structural complexity and the diverse mechanisms through which vitamin B12 exerts its preventive effects against a spectrum of health conditions, including pernicious anaemia, neurological disorders, obesity, diabetes, dyslipidaemia and complications in foetal development. The selection of articles for this review was conducted through a systematic search across multiple scientific databases, including PubMed, Scopus and Web of Science. Criteria for inclusion encompassed relevance to the biochemical impact of vitamin B12 on health, peer‐reviewed status and publication within the last decade. Exclusion criteria were non‐English articles and studies lacking empirical evidence. This stringent selection process ensured a comprehensive analysis of vitamin B12's multifaceted impact on health, covering its structure, bioavailable forms and mechanisms of action. Clinical studies highlighting its therapeutic potential, applications in food fortification and other utilizations are also discussed, underscoring the nutrient's versatility. This synthesis aims to provide a clear understanding of the integral role of vitamin B12 in maintaining human health and its potential in clinical and nutritional applications. © 2024 The Author(s). Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Characterization of the orientation dependence of magnetization transfer measures in single and crossing‐fiber white matter
Authors: Karan Philippe , Edde Manon , Gilbert Guillaume , Barakovic Muhamed , Magon Stefano , Descoteaux Maxime 
Published: June 2024

AbstractPurposeTo fully characterize the orientation dependence of magnetization transfer (MT) and inhomogeneous MT (ihMT) measures in the whole white matter (WM), for both single‐fiber and crossing‐fiber voxels.MethodsA characterization method was developed using the fiber orientation obtained from diffusion MRI (dMRI) with diffusion tensor imaging (DTI) and constrained spherical deconvolution. This allowed for characterization of the orientation dependence of measures in all of WM, regardless of the number of fiber orientation in a voxel. Furthermore, the orientation dependence inside 31 different WM bundles was characterized to evaluate the homogeneity of the effect. Variation of the results within and between‐subject was assessed from a 12‐subject dataset.ResultsPrevious results for single‐fiber voxels were reproduced and a novel characterization was produced in voxels of crossing fibers, which seems to follow trends consistent with single‐fiber results. Heterogeneity of the orientation dependence across bundles was observed, but homogeneity within similar bundles was also highlighted. Differences in behavior between MT and ihMT measures, as well as the ratio and saturation versions of these, were noted.ConclusionOrientation dependence characterization was proven possible over the entirety of WM. The vast range of effects and subtleties of the orientation dependence on MT measures showed the need for, but also the challenges of, a correction method.
Enhancement in mechanical properties of GFRP‐coal‐derived graphene oxide composites by addition of multiwalled carbon nanotubes and halloysite nanotubes: A comparative study
Authors: Garg Anushka , Basu Soumen , Mahajan Roop L. , Mehta Rajeev 
Published: June 2024

AbstractIn this study, we compare synergistic performance of two different nanofillers, namely halloysite nanotubes (HNT) clay and multiwalled carbon nanotubes (MWCNT), in conjunction with a fixed concentration (0.125 phr) of semi‐anthracite coal‐derived graphene oxide (AC‐GO) on mechanical properties improvement of EGFPs (E‐glass fiber‐based epoxy resin composites). The dispersion of AC‐GO with HNT clay (GO‐H) and AC‐GO with MWCNT (GO‐C) within epoxy matrix was achieved using sonication and homogenization. Further mixture was incorporated into mats of E‐glass fiber employing “vacuum‐assisted resin infusion molding” (VARIM). Significant enhancements (18.3% flexural strength, 14.6% tensile strength, and a slight increase of impact strength (1.8%)) were observed in EGFPs reinforced with GO‐H at 0.50 phr loading of HNT, with an AC‐GO concentration maintained at 0.125 phr. Correspondingly, optimal values for GO‐C reinforced EGFPs at 0.25 phr were 40.3%, 18.7%, and a 10.5% decrease in impact strength, respectively. Analytical techniques such as XRD, FESEM, EDX mapping, and FTIR reveal presence of relatively abundant functionalities and strong interfacial adhesion in GO‐H as well as GO‐C. The cost of HNT clay is approximately 15 times cheaper than industrial‐grade MWCNTs, therefore, these results underscore potential of GO‐H as a very economical nano‐reinforcement alternative to GO‐C for polymer nanocomposites.Highlights
0.50 phr HAGRP improves 18.3% flexural, 14.6% tensile, 1.8% impact strengths.
Beyond 0.50 phr HAGRP and 0.25 phr CAGRP, mechanical properties decreased.
0.25 phr CAGRP improves 40.3% flexural, and18.7% tensile strengths.
FESEM, FTIR reveal strong interfacial adhesion between nanofillers and epoxy.
GO‐H has proven to be an inexpensive reinforcement for polymer nanocomposites.
Effect of electromagnetic force installation method on critically reinforced interference sizes and fatigue behavior of CFRP bolted joints
Authors: Wang Xiaohe , Cao Zengqiang , Guo Yingjiang , Huo Lubin , Yu Mengchen , Cao Yuejie 
Published: June 2024

AbstractThe electromagnetic force dynamic installation (DI) method of interference fit fasteners has significant advantages in improving the quality of the assembly interface of composite structure. This study aims to investigate how improving assembly interface quality may help in achieving high‐precision interference‐fit joints in composites. Single‐lap joint specimens were prepared using electromagnetic installation technique, the fatigue life and failure behaviors of the joints under different bolt‐hole clearances were measured and analyzed experimentally. In addition, a three‐dimensional finite element model was developed to predict the radial pre‐compression stresses around the hole and the progressive failure behavior of various typical damage modes in carbon fiber‐reinforced polymer induced by the interference. The results show that the critical interference range for the DI‐composite bolted structure is 1.0%–1.2%. The fatigue life of the best interference (1.0%) and the worst interference (0%, neat fit) have a difference of 36 times in amplitude. The residual stress with uniform distribution and high amplitude reduces the stress concentration of the hole wall and improves the failure evolution of the loaded hole. The contribution of this study provides vital guidance for improving the fatigue performance of CFRP bolted structures using a novel DI method.Highlights
I = 1.0% is the critical damage‐enhancing interference size for dynamically installation interference fit bolts with electromagnetic forces.
The residual stress amplitude introduced by the interference does not increase uniformly as the interference size increases. Excessive interference significantly reduces the uniformity and magnitude of residual stresses.
Under subsequent cyclic loading, the fifth layer near the inlet and outlet of the extruded lower laminate appears to be the critical ply of extrusion deformation, and severe damage is concentrated in the critical ply of deformation.
The decrease of stress amplitude and the variation of mean stress are the mechanisms of fatigue life enhancement in interference fit joints under external cyclic loading.
Li‐decorated black phosphorene: A promising platform for gas molecule adsorption
Authors: Ebrahimi Atefe , Izadyar Mohammad 
Published: June 2024

AbstractUsing density functional theory, we investigated the adsorption of different gases, including CO, CO2, H2S, NO2, and SO2, on decorated phosphorene with various alkali metals such as Li, Na, K, Rb, and Cs. Gas molecules are physisorbed on phosphorene and, according to calculations, alkali metal decoration significantly improves the adsorption of gas molecules by phosphorene due to the reinforcement of interface interactions. Based on the stability criterion (ΔEads), the preference for choosing the best decorated phosphorene system for adsorbing different gases can be arranged as follows: Li > Na > K > Rb > Cs. Li‐phosphorene is the most stable decorated system, and due to its higher binding energy in complexation with CO, CO2, H2S, NO2, and SO2, Li‐decorated phosphorene shows greater potential in absorbing these gases. Donor‐acceptor interactions analysis has confirmed that the origin of stability can be attributed to molecular orbital interactions between these metals and the phosphorene surface (201.69 kcal mol‐1). Based on the calculated adsorption energies, Li‐decoration on black phosphorene has the most significant adsorption value for CO (−2.48 eV). Finally, Li has been suggested as the most suitable phosphorene decorator for enhanced gas molecule adsorption or detection.
Integrated quantum chemical calculations, predictive toxicity assessment, absorption, distribution, metabolism, excretion and toxicity profiling and molecular docking analysis to unveil the therapeutic potential of non‐oxovanadium(IV) and organotin(IV) complexes targeting breast cancer cells
Authors: Thakur Maridula , Kumari Shalima , Kumar Sachin , Kumari Meena 
Published: June 2024

AbstractIn this work, theoretical calculations of o‐phenylphenol‐based non‐oxovanadium(IV) and organotin(IV) complexes, previously prepared and reported by our group, have been carried out by density functional theory (DFT). Density functional theory quantum chemical computations were used to explore the structural and spectroscopic characteristics of the complexes in this study. The inhibitory nature of complexes were revealed via molecular docking research, which were performed against selected breast cancer cell proteins, 5NWH and 3HB5. The optimization and stability of complexes 1–6, were conducted using optimized DFT/B3LYP/6–311++G (d, p) level. Simulated computations of the molecular electrostatic potential surface were also performed to analyze the reactive behavior of the non‐oxovanadium(IV) and organotin(IV) complexes. The stability and molecular reactivity of the molecules were computed using the HOMO‐LUMO energies, energy gap, chemical potential (μ), electronegativity (χ), hardness (η), and softness (S) values. In silico analysis through molecular docking, ADMET properties and toxicity evaluation was used to assess its anticancer activity, drug‐likeness property and toxicity. The binding constant value, evaluated from molecular docking, was found to be very promising, −10.1 kcal mol−1 observed for vanadium complex 5 and the complexes were found to exhibit inhibition constant as low as 0.0378 μMol. Root‐mean‐square deviation (RMSD) has been carried out to validate molecular docking studies, which have been found to be below 2.0 Å for the complexes, indicating successful docking of the ligand‐protein complex by the program. The complexes, evaluated for their toxicity behavior in terms of Lethal Dose, based on Globally Harmonized System (GHS), have been found to be chemical safe falling under the category III and V and hence can find use as future metallo‐based drugs.
ZIF‐8 Composites for the Removal of Wastewater Pollutants
Authors: Ahmad Umar , Ullah Sami , Rehman Azizur , Najam Tayyaba , Alarfaji Saleh S , Jamshaid Muhammad , Parkash Kumar Ome , Ullah Sultan , Shahid Misbah , Ahmad Shah Syed Shoaib , Altaf Nazir Muhammad 
Published: June 2024

AbstractThe presence of dyes in wastewater poses a significant environmental challenge due to their permanence toxicity and potential to harm ecosystems. Because of their high porosity and adjustable characteristics, metal‐organic frameworks (MOFs) have become attractive materials for effective dye removal. Among various MOFs, zeolitic imidazolate frameworks (ZIFs) have garnered significant attention, especially ZIF‐8, for its excellent stability, significant porosity, adjustable pore size and remarkable adsorption capacity. This review article provides a comprehensive overview of recent advances in the implementation of ZIF‐8 and its composites for the removal of pollutants from wastewater. The various synthesis methods, structural characteristics and dye adsorption performance of ZIF‐8 and its composites are discussed. Furthermore, impact of the different factors such as pH, temperature, dye concentration, contact time etc. were also highlighted. Moreover, the detailed adsorption mechanism was also discussed. Finally, the current challenges and future perspectives in the production of materials based on ZIF‐8 for the removal of dyes were also presented.