bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mollaret's Meningitis: A Case Report and Review of the Literature
Authors: Hoque M Azizul , Chowdhury N , Hoque Z , Siddiqui NA , Islam R , Ahmad Q 
Published: September 2009

Mollaret's meningitis is defined as a benign recurrent aseptic meningitis characterized by three to ten episodes of fever and signs of meningeal irritation lasting between 2 to 5 days, associated with spontaneous recovery. Mollaret in 1944 described this rare form of self limiting aseptic recurrent benign meningitis. It is an extremely rare condition. Till 2002 approximately 50 cases of recurrent HSV meningitis have been described in the United States and in Europe. Here a report of a patient with recurrent meningitis, which resembles the criteria of Mollaret's Meningitis, is presented. doi: 10.3329/taj.v17i1.3489 TAJ 2004; 17(1) : 41-46
Japanese Encephalitis: Bangladesh Perspective: A Revi
Authors: Hussain Sultana M , Ekram ARM Saifuddin , Hossain MJ , Gurley E , Lubey S 
Published: September 2009

Japanese encephalitis is numerically one of the most important causes of mosquito borne viral encephalitis not only in Asia but all over the world. Japanese encephalitis infection has not been recognized in Bangladesh since an outbreak in 1977 near Mymensingh. A prospective hospital based surveillance study carried out by Centre for Health and Population Research (ICDDR,B) and the Centers for Disease Control and Prevention (CDC), USA began in June 2003 at Dhaka, Mymenhsingh and Rajshahi Medical College Hospital to find out the causes of encephalitis proved that there are 6% patient who were admitted to the hospital with the sign and symptoms of encephalitis were infected with JE. In Rajshahi Medical College Hospital 12.38% encephalitic patients had JE infection. Though the study is ongoing but these data suggest that Japanese encephalitis virus is an emerging cause of encephalitis in Bangladesh. doi: 10.3329/taj.v17i1.3493 TAJ 2004; 17(1) : 57-70
Exploring a taxonomy for aggression against women: can it aid conceptual clarity?
Authors: Cook Sarah , Parrott Dominic 
Published: September 2009

AbstractThe assessment of aggression against women is demanding primarily because assessment strategies do not share a common language to describe reliably the wide range of forms of aggression women experience. The lack of a common language impairs efforts to describe these experiences, understand causes and consequences of aggression against women, and develop effective intervention and prevention efforts. This review accomplishes two goals. First, it applies a theoretically and empirically based taxonomy to behaviors assessed by existing measurement instruments. Second, it evaluates whether the taxonomy provides a common language for the field. Strengths of the taxonomy include its ability to describe and categorize all forms of aggression found in existing quantitative measures. The taxonomy also classifies numerous examples of aggression discussed in the literature but notably absent from quantitative measures. Although we use existing quantitative measures as a starting place to evaluate the taxonomy, its use is not limited to quantitative methods. Implications for theory, research, and practice are discussed. Aggr. Behav. 35:462–476, 2009. © 2009 Wiley‐Liss, Inc.
Do aggression and rule‐breaking have different interpersonal correlates? A study of antisocial behavior subtypes, negative affect, and hostile perceptions of others
Authors: Burt S. Alexandra , Mikolajewski Amy J. , Larson Christine L. 
Published: September 2009

AbstractThere is mounting evidence that physical aggression and nonaggressive, rule‐breaking delinquency constitute two separable though correlated subtypes of antisocial behavior. Even so, it remains unclear whether these behavioral subtypes have meaningfully different interpersonal correlates, particularly as they are subsumed within the same broad domain of antisocial behavior. To evaluate this, we examined whether hostile perceptions of others (assessed via exposure to a series of neutral unknown faces) were linked to level and type of antisocial behavior aggression vs. rule‐breaking, and moreover, whether this association persisted even when also considering the common association with negative affect (as manipulated via written recollection of one's best and worst life experiences). Analyses revealed that aggression, but not rule‐breaking, was uniquely tied to hostile perceptions of others. Furthermore, this association persisted over and above the common association of both hostile perceptions and aggression with negative affect (at both trait and state levels). Such results provide additional support for clinically meaningful differences between the behavioral subtypes of aggression and nonaggressive rule‐breaking and for the independent role of hostile perceptions in aggressive behavior. Aggr. Behav. 35:453–461, 2009. © 2009 Wiley‐Liss, Inc.
Charge‐Reversal Drug Conjugate for Targeted Cancer Cell Nuclear Drug Delivery
Authors: Zhou Zhuxian , Shen Youqing , Tang Jianbin , Fan Maohong , Van Kirk Edward A , Murdoch William J , Radosz Maciej 
Published: September 2009

AbstractDNA‐toxin anticancer drugs target nuclear DNA or its associated enzymes to elicit their pharmaceutical effects, but cancer cells have not only membrane‐associated but also many intracellular drug‐resistance mechanisms that limit their nuclear localization. Thus, delivering such drugs directly to the nucleus would bypass the drug‐resistance barriers. The cationic polymer poly(L‐lysine) (PLL) is capable of nuclear localization and may be used as a drug carrier for nuclear drug delivery, but its cationic charges make it toxic and cause problems in in‐vivo applications. Herein, PLL is used to demonstrate a pH‐triggered charge‐reversal carrier to solve this problem. PLL's primary amines are amidized as acid‐labile β‐carboxylic amides (PLL/amide). The negatively charged PLL/amide has a very low toxicity and low interaction with cells and, therefore, may be used in vivo. But once in cancer cells' acidic lysosomes, the acid‐labile amides hydrolyze into primary amines. The regenerated PLL escapes from the lysosomes and traverses into the nucleus. A cancer‐cell targeted nuclear‐localization polymer–drug conjugate has, thereby, been developed by introducing folic‐acid targeting groups and an anticancer drug camptothecin (CPT) to PLL/amide (FA‐PLL/amide‐CPT). The conjugate efficiently enters folate‐receptor overexpressing cancer cells and traverses to their nuclei. The CPT conjugated to the carrier by intracellular cleavable disulfide bonds shows much improved cytotoxicity.
Embryonic States of Fluorapatite–Gelatine Nanocomposites and Their Intrinsic Electric‐Field‐Driven Morphogenesis: The Missing Link on the Way from Atomistic Simulations to Pattern Formation on the Mesoscale
Authors: Simon Paul , Rosseeva Elena , Buder Jana , Carrillo‐Cabrera Wilder German , Kniep Rüdiger 
Published: September 2009

AbstractThe shape development of fluorapatite (FAP)–gelatine nanocomposites is revealed by means of HRTEM investigations starting from molecular dimensions up to the formation of mesoscaled (elongated) hexagonal prisms. The composite nature of the aggregates is proved by IR spectroscopy and by chemical analyses on all states of shape development. The initial states are characterized by triple‐helical fiber protein bundles, which are mineralized step‐by‐step forming and fixing nanoplatelets of FAP in a mosaic arrangement. After being fully mineralized the bundles form elongated composite nanoboards. In the next step of the growth process the boards aggregate to bundles of boards which are in a more or less parallel alignment with respect to each other. By adding up more and more composite nanoboards a critical size is reached and an electric field is developed, which takes over control and directs the further development of the aggregates. This kind of electric‐field‐directed growth of the elongated polar nanoboards additionally leads to the formation and inclusion of protein nanofibrils into the growing composite aggregate. By this method, cone‐like nanofibril structures develop along the long axis of the aggregates accompanied by more perfect parallel alignment of the composite boards within the aggregates. Further shape development is characterized by adding up composite nanoboards, in particular to increase the third dimension in volume. This thickening process preferably takes place in the middle part of the elongated aggregates and finally proceeds to their basal ends until a perfect hexagonal prismatic seed is formed, which then is ready for further shape development on the micrometer scale.
Definitions of the phenotypic manifestations of sickle cell disease
Authors: Ballas Samir K. , Lieff Susan , Benjamin Lennette J. , Dampier Carlton D. , Heeney Matthew M. , Hoppe Carolyn , Johnson Cage S. , Rogers Zora R. , Smith‐Whitley Kim , Wang Winfred C. , Telen Marilyn J. 
Published: September 2009

AbstractSickle cell disease (SCD) is a pleiotropic genetic disorder of hemoglobin that has profound multiorgan effects. The low prevalence of SCD (∼100,000/US) has limited progress in clinical, basic, and translational research. Lack of a large, readily accessible population for clinical studies has contributed to the absence of standard definitions and diagnostic criteria for the numerous complications of SCD and inadequate understanding of SCD pathophysiology. In 2005, the Comprehensive Sickle Cell Centers initiated a project to establish consensus definitions of the most frequently occurring complications. A group of clinicians and scientists with extensive expertise in research and treatment of SCD gathered to identify and categorize the most common complications. From this group, a formal writing team was formed that further reviewed the literature, sought specialist input, and produced definitions in a standard format. This article provides an overview of the process and describes 12 body system categories and the most prevalent or severe complications within these categories. A detailed Appendix provides standardized definitions for all complications identified within each system. This report proposes use of these definitions for studies of SCD complications, so future studies can be comparably robust and treatment efficacy measured. Use of these definitions will support greater accuracy in genotype–phenotype studies, thereby achieving a better understanding of SCD pathophysiology. This should nevertheless be viewed as a dynamic rather than final document; phenotype descriptions should be reevaluated and revised periodically to provide the most current standard definitions as etiologic factors are better understood, and new diagnostic options are developed. Am. J. Hematol. 2010. © 2009 Wiley‐Liss, Inc.
Pleural plaques in dentists from occupational asbestos exposure: A report of three cases
Authors: Sichletidis L. , Spyratos D. , Chloros D. , Michailidis K. , Fourkiotou I. 
Published: September 2009

AbstractBackgroundWhite asbestos (chrysotile) has been used in dentistry since 1930 when it was introduced as a lining material for casting rings.MethodsAll three patients presented with pleural plaques on chest X‐rays as well as on CT‐scans. They were working as dentists for 35–45 years. Under the instructions of the first dentist we represented precisely the whole process of manipulating a kind of paper that contained asbestos. In order to measure asbestos fibers concentration we used the membrane filter method and phase contrast optical microscopy. Dry asbestos sheets were scanned with x‐ray diffraction and electron microscope.ResultsAnalysis of the filter demonstrated 0.008 fibers/cm3 during the sampling period. X‐ray diffraction analysis revealed that the material consisted of chrysotile exclusively. Electron microscope pictures confirmed the presence of chrysotile.ConclusionEveryday occupational exposure for many years even to low asbestos levels, under poor ventilation conditions in a closed space, could cause pleural lesions. Am. J. Ind. Med. 52:926–930, 2009. © 2009 Wiley‐Liss, Inc.
Teaching bovine abdominal anatomy: Use of a haptic simulator
Authors: Kinnison Tierney , Forrest Neil David , Frean Stephen Philip , Baillie Sarah 
Published: September 2009

AbstractTraditional methods of teaching anatomy to undergraduate medical and veterinary students are being challenged and need to adapt to modern concerns and requirements. There is a move away from the use of cadavers to new technologies as a way of complementing the traditional approaches and addressing resource and ethical problems. Haptic (touch) technology, which allows the student to feel a 3D computer‐generated virtual environment, provides a novel way to address some of these challenges. To evaluate the practicalities and usefulness of a haptic simulator, first year veterinary students at the Royal Veterinary College, University of London, were taught basic bovine abdominal anatomy using a rectal palpation simulator: “The Haptic Cow.” Over two days, 186 students were taught in small groups and 184 provided feedback via a questionnaire. The results were positive; the majority of students considered that the simulator had been useful for appreciating both the feel and location of key internal anatomical structures, had helped with their understanding of bovine abdominal anatomy and 3D visualization, and the tutorial had been enjoyable. The students were mostly in favor of the small group tutorial format, but some requested more time on the simulator. The findings indicate that the haptic simulator is an engaging way of teaching bovine abdominal anatomy to a large number of students in an efficient manner without using cadavers, thereby addressing some of the current challenges in anatomy teaching. Anat Sci Educ 2: 280–285, 2009. © 2009 American Association of Anatomists
Membrane interactions of antimicrobial β‐peptides: The role of amphipathicity versus secondary structure induction
Authors: Hall Kristopher , Aguilar Marie‐Isabel 
Published: September 2009

AbstractThe membrane interaction of two beta peptides was studied using a surface plasmon resonance biosensor. The two peptides are β‐17, a novel β‐amino acid based antimicrobial peptide and the corresponding scrambled‐β17—a non‐antimicrobial β‐peptide analogue. Membrane interaction studies were performed with a series of phospholipid mixtures which mimic either mammalian cells (high in phosphatidylcholine and cholesterol) or microbial cells (high in phosphatidylethanolamine and phosphatidylglycerol). The results were compared with the membrane binding of the well‐characterized antimicrobial peptide magainin 2. The secondary structure of these peptides were also determined in each lipid mixture by circular dichroism and correlated with the membrane‐binding properties. Both β‐17 and the scrambled peptide have the same peptide length, charge and showed a similar secondary structure in both aqueous buffer and in the presence of liposomes. Both peptides also bound to a similar level on each membrane mixture, showing that the dramatic difference in biological activity is not based on the amount of peptide bound but rather differences in the degree of insertion and rate of membrane dissociation. Although β‐17 and the scrambled β‐17 peptide exhibited similar binding properties on all membrane mimics, both β‐peptides bound more to all membranes compared with magainin 2. Overall, the results further reveal the significant interplay between peptide amphipathicity and secondary structure induction on membrane binding. © 2009 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 92: 554–564, 2009.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
The effects of option framing on consumer choices: Making decisions in rational versus experiential processing modes
Authors: Biswas Dipayan 
Published: September 2009

Abstract

In the marketplace, consumers often encounter framed scenarios for optional product features, whereby they can add desired product options to a base model or delete undesired product options from a fully loaded model. The results of two experiments show that such option framing can influence consumers' decision making regarding the total number of finally chosen product options. Also, consumers' processing modes – rational versus experiential, can influence their choice behavior under option framing. Specifically, consumers choose a higher number of options in the delete (versus add) frame, and the effect is magnified when making decisions in an experiential mode, and it is diminished when making decisions in a rational mode. Moreover, cognitive constraints further moderate these effects.
Copyright © 2009 John Wiley & Sons, Ltd.
Development of New and Selective Trypanosoma cruzi trans‐Sialidase Inhibitors from Sulfonamide Chalcones and Their Derivatives
Authors: Kim Jin Hyo , Ryu Hyung Won , Shim Jae Hoon , Park Ki Hun , Withers Stephen G. 
Published: September 2009

AbstractA series of sulfonamide‐containing hydroxylated chalcone (4–7) and quinolinone (8, 9) derivatives was synthesised and tested for inhibition of the trans‐sialidase from Trypanosoma cruzi (TcTS). IC50 values for these inhibitors ranged from 0.6 to 7.3 μM, with the dihydroxylated (catechol) derivatives being the tightest binders. Full kinetic analyses of inhibition were performed for these catechol derivatives, both for the transglycosylation reaction in the presence of lactose and for the hydrolysis reaction in its absence. Competitive inhibition was seen in each case with Ki values for 5, 7 and 9 of 2.0, 2.2 and 0.2 μM, respectively, in the absence of lactose, and 4.6, 3.7 and 0.4 μM in its presence. None of the compounds tested showed any significant inhibition of the human sialidase Neu2, at concentrations up to 200 μM.
Moral cognitive correlates of empathy in juvenile delinquents
Authors: Barriga Alvaro Q. , Sullivan‐Cosetti Marilyn , Gibbs John C. 
Published: September 2009

AbstractIntroduction Numerous theories of anti‐social behaviour have featured lack of empathy as an essential characteristic of the anti‐social personality.Aim To investigate the relationships between empathy and three theoretically related moral cognitive constructs: moral judgement maturity, moral identity and self‐serving cognitive distortion.Methods Seventy‐eight adjudicated juvenile delinquents aged 13 to 21 years who had been directed by the court to attend a 10‐week empathy training programme completed self‐report measures as part of routine evaluation. Their anonymised scores were retrieved from programme records.Results Applying zero‐order correlation, followed by regression analysis, we established that moral judgement maturity was associated with greater empathy, whereas extensive endorsement of self‐serving cognitive distortions was associated with lower empathy. An observed association between moral identity and empathy was mediated or ‘neutralised’ by self‐serving cognitive distortion.Conclusions and implications for practice Our results suggest that interventions designed to promote empathy and curtail anti‐social behaviour should embrace strategies that facilitate moral judgement maturity and correct or counteract self‐serving cognitive distortions. Copyright © 2009 John Wiley & Sons, Ltd.
Histology of highly echolucent regions in optical coherence tomography images from two patients with sirolimus‐eluting stent restenosis
Authors: Nagai Hiroyuki , Ishibashi‐Ueda Hatsue , Fujii Kenshi 
Published: September 2009

AbstractWe report on two patients with sirolimus‐eluting stent (SES) restenosis lesions who showed highly echolucent regions by optical coherence tomography (OCT) and who could be assessed histologically after removal by directional coronary atherectomy (DCA). One restenosis lesion had a bilayer structure of hyperechoic outer layers and highly echolucent inner layers on OCT images and histologically exhibited myxomatous neointima tissue in the highly echolucent regions; another restenosis case showed patchy and highly echolucent regions throughout the layers and its histology revealed fibrin thrombosis. We should be aware that patterns of echolucent on OCT images may have various histology. OCT allows the visualization of fine lesions that conventional intravascular ultrasound (IVUS) cannot provide. The OCT images of drug‐eluting stent restenosis lesions often show echolucent regions [Shuzoh et al., EuroInterv 2006;1:484]. However, no histological study of the lesions has been reported to date. Here we report on two patients with SES restenosis lesions that showed highly echolucent regions by OCT and that could be assessed histologically after removal by DCA. © 2009 Wiley‐Liss, Inc.
Side‐branch wire entrapment during bifurcation PCI: Avoidance and management
Authors: Burns Andrew T. , Gutman Jack , Whitbourn Rob 
Published: September 2009

AbstractAn LAD/D1 bifurcation intervention was complicated by side‐branch wire entrapment and unravelling requiring goose‐neck snare removal. Residual microfilaments were retrieved from the main branch after further balloon inflations with a satisfactory final angiographic result and one‐year follow‐up. Various methods are available to avoid and deal with this complication. © 2009 Wiley‐Liss, Inc.
Percutaneous management of a Fontan fenestration: In search for the ideal restriction—occlusion device
Authors: Boshoff Derize E. , Brown Stephen C. , Degiovanni Joseph , Stumper Oliver , Wright John , Mertens Luc , Gewillig Marc 
Published: September 2009

AbstractObjective: Most devices devices available for percutaneous closure of Fontan fenestrations tend to be bulky. The aim of this study was to evaluate a low profile custom made device and assess its efficacy and safety. Patients and Methods: A 15 mm PFO star was used as the basis. The following modifications were made: removal of the left disc to reduce thrombogenicity in the left atrium, increase the length of the LA legs from 2 by 15 mm to 3 by 20 mm to prevent dislodgement and later adding a pivot between the left and right umbrella. A partial occluder was made by removing two opposite quadrants from the proximal disk. Results: Device deployment was possible in 93% (63 of 68) patients. In five patients, the device could not be deployed and an alternative device was used. In 45 patients complete closure of the fenestration was obtained and saturations increased from 84% ± 4% to 95% ± 2% (P < 001). In 18 high risk patients with suboptimal Fontan circulation, a modified device was used to effect partial occlusion: saturations increased from 79% ± 7% to 90% ± 4% (P < 0.001); a residual shunt persisted in most patients for several months. No thrombotic events were recorded during follow‐up. Conclusions: The modified PFO star device can safely be deployed in Fontan patients to occlude or restrict flow through a fenestration. It has a low profile with minimal foreign material, is non‐obstructive and minimally thrombogenic. © 2009 Wiley‐Liss, Inc.