bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early Prenatal Diagnosis of Inborn Error of Metabolism: A Case Report of a Fetus Affected with Fabry's Disease
Authors: Tsutsumi Osamu , Sato Masahito , Sato Kodo , Sato Kazuo , Mizuno Masahiko , Sakamoto Shoichi 
Published: August 2010

AbstractA microassay method for early prenatal diagnosis of inborn error of metabolism using cultured amniotic cells was developed and Fabry's disease was diagnosed prenatally. After several days of culture small freeze‐dried cell samples (about 1 μg of dry weight) were prepared and weighed on a quartz fiber fish‐pole balance, then incubated in 5μl of assay mixture in the microtube for a‐galactosidase. Severe deficiency of the enzyme activity and male karyotype suggested that the fetus was hemizygous. After termination of pregnancy, diagnosis was confirmed by proving the enzyme deficiency in various tissues. Morphological study revealed that abnormal accumulation started early in the prenatal stage.
The Physiological Role of the Sitting Parturient Posture
Authors: Mori Hiroyuki , Chen Shin‐Zon , Aisaka Kozo , Matsuoka Ryo , Kigawa Tomonori 
Published: August 2010

AbstractClinical data from 34 deliveries in the sitting position were compared with 59 supine deliveries. There were no significant differences between the two groups either in the duration of labor or in fetal well‐being as measured by data from the FHR pattern, umbilical blood gas analysis and APGAR score. However, analysis of the uterine contraction wave revealed a significant elevation of the resting tonus and shortening of the duration of the uterine contraction in the sitting group. These suggest that the reduced duration of the uterine contraction gave equivalent or better delivery force. Mothers declared they were more comfortable and could more easily make bearing‐down efforts in the sitting position than in the supine position.It is concluded that labor in the sitting position is not only a physiological but also a favorable posture for the management of labor.
Down Syndrome and Maternal Age in Hong Kong Chinese
Authors: Ghosh A. , Woo J. S. K. , Chan C. L. , Poon I. , Fok T. F. , Wong V. C. W. , Ma Ho‐Kei 
Published: August 2010

AbstractMaternal age specific incidence of Down Syndrome in the Chinese has, up to now, been unavailable in the literature. The incidence of Down Syndrome births and the maternal age distribution for the period 1962 to 1980 were ascertained from hospital records and registers at the University teaching hospital in Hong Kong where over 99% of the patient population are of Chinese descent. Three mathematical models were studied to derive the smoothed rates for the age specific incidence of Down Syndrome. The polynomial regression exponential model, with the equation Iny = ‐ 1.2194 – .1245x + .0049x2 showed the best fit. The overall icidence of Down Syndrome was found to be 1 in 1114 live births. A lower rate was observed in the study population along the whole range of maternal age, as compared with the Caucasian counterpart. The possibility of underdiagnosis was evaluated.The percentage of pregnant women over 35 years decreased from 16.2 in the period 1962–1970 to 8.6 in the period 1971 to 1980. Of the total Down births the contribution from those over the age of 35 years decreased from 64.7% to 54.7%. An increase in the incidence of Down births however was demonstrable in mothers aged 35 to 39 delivering during the period.Based on maternal age distribution for 1979 and 1980, a reduction of Down births by 7 and 12% will be achieved assuming a one‐third compliance rate when the cut‐off point for maternal age in the amniocentesis programme is 40 and 35 years respectively.
Progress Report on Nationwide Networking System of Perinatal Summary Records
Authors: Yamamoto Koji , Ogura Hisakazu , Furutani Hiroshi , Kitazoe Yasuhiro , Takeda Yoshihiko 
Published: August 2010

AbstractA pilot system of nationwide networking of perinatal records, which is operational at Osaka University Computation Center, is introduced. The system was developed mainly to analyze operating problems inherent in such a nationwide data entry system. It provides a handy tool for entry and analysis of perinatal summary records by using a time‐sharing terminal. Great care was taken in data security. To each user and each item, security levels are assigned. Users can not see detailed values of items which have a higher security level than their own. All records and items are available for statistical calculations, however. The system was tested by 8 university hospitals (Univ. of Tokyo, Nihon Univ., Keio Univ., Hamamatsu Univ., Kitazato Univ., Univ. of Osaka, Tottori Univ. and Kyushu Univ.), who reported success in using the system while incurring only low running costs.
Calmodulin in Breast Milk, and Umbilical and Maternal Plasma
Authors: Hira Takaaki , Fukumoto Seigo , Kono Shinzo , Takenaka Shizuhiro 
Published: August 2010

AbstractCalmodulin concentrations were determined by radioimmunoassay in breast milk and the plasmas of cord vessels and of nonpregnant and pregnant women. Calmodulin concentrations in the maternal plasma rose slightly in the 36–39th week of gestation, maintained a high level until the 5th postpartum day, and then decreased to nearly the non‐pregnant control level. Among intrapartum plasma samples calmodulin concentration increased in the order: umbilical vein, umbilical artery, maternal peripheral vein. The breast milk calmodulin concentrations on the 5th and 30th postpartum day were 8.7‐ and 10.5‐times higher respectively than those in the maternal plasma obtained simultaneously. The calmodulin concentrations in breast milk, and maternal and umbilical plasma were too low to bind all the calcium contained in these samples. These results suggest that calmodulin is also present in the human mammary gland and that it might play some role in modulating the calcium transport there.
Suppressive Effect of Prostaglandin D2 on Prolactin Secretion from Rat Anterior Pituitary
Authors: Arisawa Masayoshi , Makino Tsunehisa , Izumi Sun‐ichiro , Lizuka Rihachi 
Published: August 2010

AbstractProstaglandin D2 (PGD2) was investigated for its effect on prolactin (PRL) secretion from rat anterior pituitary in vitro and in vivo. Significant suppression in the release of PRL was observed when the anterior pituitaries were incubated for 4 hours in vitro in the presence of more than 100 μg of PGD2/ml incubation medium. In the second experiment, animals received intravenous injections of PGD2 after pretreatment of ovariectomized mature rats with estrogen and progesterone. Thirty minutes after injection of 250 μg or 500 μg of PGD2, serum PRL levels were significantly lower than levels before the PGD2 injection. The injection of the vehicle control did not affect serum PRL levels.These results suggest that at high dosages PGD2 suppresses PRL secretion by acting directly on the rat anterior pituitary gland.
Mid‐Trimester Therapeutic Abortion by Vaginal Suppository of 16, 16‐Dimethyl‐Trans‐Δ2 ‐Prostaglandin E1
Authors: Kato Koichi , Furuya Kenichi , Makimura Noriko , Nagata Ichiro , Ishida Masami , Seki Katsuyoshi 
Published: August 2010

AbstractA new analog of PGE1 was vaginally administered with (n=20) or without (n=29) laminaria tents and metreurynter to pregnant women during mid‐trimester for therapeutic abortion. All patients successfully aborted. The abortion time was short, the amount of bleeding was small, and there was little difference between patients treated with 16 DM‐PGE1 alone and those treated with 16 DM‐PAGE1, laminaria tents, and metreurynter. However, amounts of 16 DM‐PGE1 required for abortion were significantly greater in patients treated with 16 DM‐PGE1 alone. Occurrences of side effects increased with increased amounts of 16 DM‐PGE1 administered. Therefore, vaginal administration of 16 DM‐PGE1 in combination with the use of laminaria tents and metreurynter successfully induced abortion in women during mid‐trimester with minimal side effects, and was considered to be the best method presently available for mid‐trimester therapeutic abortion.
Unexplained Menorrhagia: Problems with Management
Authors: Oronsaye Augustine U. , Orhue Augustine E. , Unuigbe Jacob A. 
Published: August 2010

AbstractThe cases of menorrhagia in the absence of pelvic or other pathology, seen and managed at the University of Benin Teaching Hospital, over a six year period (1975–1980) are reviewed with a view to appraising the rational and effectiveness of medical (drug) and surgical management.The results suggest a haphazard approach in management in a majority of the cases. Suggestions are hereby made for consideration of an organised approach to both the diagnosis and treatment of these cases.
Multivariate Analysis of Singapore Birth Weights
Authors: Lun Kwok‐Chan , Tan Nalla R. , Hughes Kenneth 
Published: August 2010

AbstractEarly studies have established that birth weight is influenced by a host of genetic and environmental factors. For this reason, the merit of examining the relationship of this anthropometric measurement with any one factor in isolation using simple bivariate studies is suspect. Although stratified analysis has been used as an alternative approach, its limitation becomes immediately obvious as the number of confounding factors requiring control increases. Later studies on factors affecting birth weight variation have recoursed to the use of the Multiple Linear Regression (MLR) technique.This paper reports the effects of seven factors on variation in a Singapore sample of 23, 591 singleton birth weights collected between 1967 through 1974. The dummy variable approach was adopted for the MLR analysis to relax the restriction of a linear relationship between some of the measurement variables, such as gestational length and maternal age, with birth weight.The results show that sex, birth order, father's occupation and ethnic group are significant factors affecting birth weight variation. Maternal age appears to be significant for mothers below 35 years as is gestational length before 42 weeks. Place of residence has no significant effect. The concordance of the findings with results from studies done elsewhere is discussed.
Hysterosalpingography II. The Efficacy of Glucagon as a Spasmolytic in Overcoming Tubal Spasm during Hysterosalpingography
Authors: Anandakumar C. , Rauff Mary , Wong Eric , Wong P.C. , Ratnam SS 
Published: August 2010

AbstractThe purpose of this study was to evaluate the efficacy of Glucagon as a spasmolytic in overcoming tubal spasm during hysterosalpingography. From this study we found that Glucagon was not an effective spasmolytic to overcome tubal spasms during hy sterosalpingogram.
Change of Catecholamine Turnover in Ovary during the Rat Estrous Cycle
Authors: Nagahara Yasuhito , Miyake Akira , Koike Koji , Sakumoto Tetsurou , Aono Toshihiro 
Published: August 2010

AbstractThe changes in rate of turnover of catecholamines (CA) in rat ovary during the estrous cycle were examined. The monoamine oxidase inhibitor pargyline (80mg/kg ip), or saline as a control was injected at 12:00 h of each stage of the ovarian cycle, animals were decapitated 1 h later, and their ovaries were removed. Norepinephrine (NE) and dopamine (DA) were extracted and measured by high performance liquid chromatography with electrochemical detection. The turnover rate of NE in the ovary was significantly (P>0.05) lower in proestrus of the estrous cycle than in diestrus‐1 and diestrus‐2. The turnover rate of DA in the ovary was slightly, but not significantly, lower in proestrus than in other stages of the ovarian cycle. These results suggest that decrease in the NE turnover rate in the ovary may be involved in the ovulatory process.
Correlation Between Amniotic Fluid Lecithin‐Sphingomyelin (L/S) Ratio and Optical Density Measured after Centrifugation at Varying Forces
Authors: Shimokawa Hiroshi , Hisanaga Sachio , Maesato Soei , Kashiwabara Yoshiro , Maeda Hirotaka , Oki Satoshi , Nakano Hitoo 
Published: August 2010

AbstractThe present study was carried out for two reasons: to investigate the correlation between amniotic fluid lecithin/sphingomyelin (L/S) ratio and optical density at wavelengths ranging from 350 nm to 650 nm, and to determine the effect of centrifugal force on that correlation.When an L/S ratio of 2.0 and optical density values of 0.15 at 650 nm, 0.16 at 600 nm and 0.17 at 575 nm were taken as discriminative values between pulmonary maturity and immaturity, the true positive rate of samples centrifuged at 450xg was not different from that of samples centrifuged at 2000xg, but the false negative rate was high among the samples centrifuged at 2000xg (P>0.005).These results indicate that for amniotic fluid centrifuged at 450xg, the optical density at wavelengths ranging from 575 nm to 650 nm provides a rapid, simple, accurate indicator of fetal lung maturity.
Prevalence of Infertilit‐ in Urban and Rural Thailand
Authors: Koetsawang Suporn , Satayapan Suwanee , Jivasak‐Apimas Supanee , Belse‐ Elizabeth M. , Pinol A. 
Published: August 2010

AbstractIn 1981, a stud‐ of infertilit‐ rates was carried on b‐ interviewing a total of 2087 women between 15–48 ‐ears old in Bangkok (636) and four rural areas in the North (354), North East (538), Central (387) and South (172). The rate of primar‐ infertilit‐ in all areas was ver‐ low (2%) and constant. The prevalence of secondar‐ infertilit‐ rose sharpl‐ from 3–4% in their twenties to at least 25% in those age 40 or over. The majorit‐ of these women, however, expressed no desire for further children as the‐ alread‐ had enough children. The rate of secondar‐ infertilit‐ was lowest in the North East (5.2%), highest in the South (18.6). Similar secondar‐ infertilit‐ rates were found in Bangkok (7.1%), Central (7.2%) and the North (9.6%).
Initial Experience with Vincristine, Adriam‐cin and Cisdichlorodiammine Platinum Combination Chemotherap‐ of Advanced Ovarian Carcinoma
Authors: Sen Dilip K. , Zaleha Siti , Sivanesaratnam V. , Adlan Ahmad , Meng Looi Lai 
Published: August 2010

AbstractA combination of Cis‐dichlorodiammine platinum, Adriam‐cin and Vincristine was used on two groups of patients with advanced ovarian carcinoma of epithelial origin (stage III and IV).In the first group of thirteen patients resistant to previous chemotherap‐, the overall response rate was 46.2% (six cases). 15.4% (two cases) showed complete response.In the second group of four patients who had no previous chemotherap‐, three cases showed partial response, and one case showed no response.Toxicit‐ consisted of nausea and vomiting, leukopaenia of less than 1000/ml in 4 cases and inappropriate ADH secretion in 2.
Sporadic Ovulation in a Case of Resistant Ovar‐ Syndrome
Authors: Mori Hiro‐uki , Matsuoka R‐o , Aisaka Kozo , Kigawa Tomonori 
Published: August 2010

SummaryA case of h‐pergonadotropic secondar‐ amenorrhea with presence of ovarian primordial follicles is reported. This patient with resistant ovar‐ s‐ndrome was h‐posensitive to the exogenous gonadotropin treatment, but an ovulation occurred spontaneousl‐ after the sequential administration of estrogen and progestogen.
The Coexistence of Carcinoma and Tuberculosis in the Uterine Cervix: Report of 2 Cases
Authors: Hsu Chien‐Tien , Yang Li‐Chung , Hsu Mei‐Lien , Chen Wu‐Hsiung , Lin ‐un‐Nan 
Published: August 2010

AbstractCoexistence of tuberculosis and cancer in the uterine cervix is extremel‐ rare. Two of such cases are presented. In these cases, extension of tuberculous lesions is much wider than cancerous lesions. Pathological findings and positive acid‐fast stained M‐cobacterium tuberculosis in the tissue give authenticit‐ to the two cases. With regard to mutual influence between the two clinical entities nothing can be said on the basis of onl‐ two cases. However, it seems that at least tuberculosis did not aggravate the cancerous lesion.
Acute Fatt‐ Liver of Pregnanc‐ with H‐perlipidemia, Acute Hemorrhagic Pancreatitis and Disseminated Intravascular Coagulation
Authors: Minakami Hisanori , Kimura Kozo , Kanazawa Takashi , Tamada Taro , Kaneko Kou 
Published: August 2010

AbstractAn autops‐ case of a 32‐ear old nulliparous woman who died of acute fatt‐ liver of pregnanc‐ (AFLP) associated with h‐perlipidemia, acute hemorrhagic pancreatitis and disseminated intravascular coagulation (DIC) is reported. Although acute pancreatitis has been reported as one of the major complications of AFLP, their interrelationships are poorl‐ understood because of the rarit‐ and the fulminating nature of this disease. H‐perlipidemia has been interpreted as the etiological factor in acute pancreatitis. It is also known that an increase in circulating lipids occurs during pregnanc‐ ph‐siologicall‐. AFLP presents itself onl‐ in the last trimester of pregnanc‐. The intention of the following report is to document a case of AFLP with evidence of supra‐ph‐siologic h‐perlipidemia and to discuss the pathogenesis of AFLP and acute pancreatitis.
Endometriosis and Various Pelvic Lesions Associated with H‐perprolactinemia
Authors: Abe Jun , Kimura Junji , Hirose Toshi‐uki , Tama‐a Teruhiko , Okada Hiroji 
Published: August 2010

AbstractThe serum prolactin (PRL) levels of 34 cases of endometriosis, 26 cases of adeno‐m‐osis, 30 cases of functional d‐smenorrhea, and 9 patients with m‐oma uteri were measured b‐ radioimmunoassa‐.The incidence of h‐perprolactinemia (>22 ng/ml) was 100, 38.0, 30.8, 40.0 and 44.4% in cases of Acosta's severe t‐pe, Beecham II and III groups, adenom‐osis, functional d‐smenorrhea, and m‐oma uteri, respectivel‐. The rate of galactorrhea was 19% of Acosta's severe cases, the highest among the five groups. The mean value of peripheral PRL in Acosta's severe t‐pe was significantl‐ higher than that of the other four groups.The immunohistochemical stud‐ on PRL localization demonstrated the positive reaction at the apical membrane of the glands in normal and ectopic endometria, suggesting PRL binding sites rather than production sites.The PRL levels of the operated group tended to decrease spontaneousl‐ after operation. Among the various hormone treatments, it was of interest that some cases improved s‐mptomaticall‐ and objectivel‐ after treatment with bromocriptine alone.Our stud‐ suggests that PRL, as one of hormonal factors, ma‐ pla‐ a role in the development of endometriosis.
Treatment of Pelvic Endometriosis with Gestrinone ‐Report on 9 Cases ‐
Authors: Tama‐a Teruhiko , Fujimoto Jiro , Okada Hiroji 
Published: August 2010

AbstractNine patients with pelvic endometriosis were treated with gestrinone in a dose of 2.5 mg twice weekl‐ for 6 to 7 months. All patients became anovulator‐ with sporadic episodes of painless uterine bleeding lasting various periods of time, until the‐ became amenorrheic. Considerable lessening of the objective findings such as nodular lesions in the posterior cul‐de‐sac, adnexal mass, uterine mobilit‐ and pelvic tenderness were found. Major side effects recorded were acne in 2 patients, transient increased discharge in 3 patients, and hoarseness in 1 patient. Abnormal increase of serum transaminases was observed in 3 patients, who did not discontinue tne therap‐. Follow‐up of 8 patients until 12 weeks after discontinuation of therap‐ showed that ovulation, determined b‐ basal bod‐ temperature, returned within 7 to 50 (22.8 + 4.9[SE]) da‐s and that objective findings were not remarkabl‐ changed, but subjective findings such as pelvic pain in menses reappeared in 5 of 8 patients.
Clinical Application of Dih‐drotestosterone (DHT) Binding Assa‐ of Cultured Skin Fibroblasts for the Prospective Differential Diagnosis of Testicular Feminization S‐ndrome (TFS)
Authors: Wakimoto Hiroshi , Taka‐asu Susumu , Kurachi Hirohisa , Komura Hiroko , Mi‐ake Akira , Aono Toshihiro , Tanizawa Osamu , Matsumoto Keishi 
Published: August 2010

AbstractThe present stud‐ was conducted to evaluate the usefulness of dih‐drotestosterone (DHT) binding assa‐ of skin fibroblasts for the differential diagnosis in infants of testicular feminization s‐ndrome (TFS) from other disorders with genital anomalies. DHT binding was measured in the fibroblasts derived from the patients with intersex or genital anomalies such as TFS, incomplete TFS, pure gonadal agenesis, retentio testis, Klinefelter's s‐ndrome, testicular d‐sgenesis, adrenogenital s‐ndrome, and Turner's s‐ndrome. All patients except the TFS patients exhibited normal binding capacit‐ in fibroblasts from either genital or nongenital skins. The patients with TFS were 3 and 6 ‐ear‐old siblings whose diagnosis had not been made completel‐ b‐ g‐necological examination and routine laborator‐ tests, but the binding assa‐ contributed to making the exact diagnosis of these patients. DHT binding of skin fibroblasts from normal males and females was 11.5±8.6 (S. D.) fmoles/mg cell protein in nongenital skin, whereas the DHT binding assa‐ of these patients showed that the maximal number of binding sites was under 0.5 fmoles/mg cell protein. These results suggest that DHT binding assa‐ of skin fibroblasts is useful also for the prospective differential diagnosis of TFS in infant and prepubertal patients and that treatment for TFS might be planned from infanc‐.
Serum Progesterone and Endometrial Dating for Confirmation of Ovulation and Corpus Luteum Function
Authors: Said Sam‐ A. , Galal Rawia A. , Shams Ahmed T. , Ahmed Abul Magid M. , Na‐el Sa‐ed A. 
Published: August 2010

AbstractSimultaneous premenstrual endometrial biops‐ and serum progesterone determination were done on 13 anovulator‐ and 42 ovulator‐ cases. It was found that serum progesterone level of 3 ng/ml diagnostic of ovulation if the samples are taken between da‐s 17–24. Lower levels are seen on the extremes of the ovulator‐ c‐cles. Moreover serum progesterone levels above 5 ng/ml on da‐s 17–24 mostl‐ indicate adequate corpus luteum function.
Changes in LHRH in Human Maternal Plasma during Pregnanc‐
Authors: Kawamura ‐asuhiro , Miyake Akira , Sakumoto Tetsuro , Tasaka Keiichi , Aono Toshihiro 
Published: August 2010

AbstractThe changes in luteinizing hormone‐releasing hormone (LHRH) and human chorionic gonadotropin (hCG) concentrations in the maternal plasma during pregnanc‐ were determined b‐ radioimmunoassa‐. The mean (±SE) plasma levels of immunoreactive LHRH in all pregnant women (2.4±0.5 pg/ml) were significantl‐ lower than those in normal c‐cling women (4.2±0.3 pg/ml). When the mean levels were measured ever‐ 4 weeks, levels from the 8th to the 19th week and from the 32nd to the 41st week of pregnanc‐ were found to be significantl‐ lower than those in normal c‐cling women. However, the levels of LHRH at each stage of pregnanc‐ did not var‐ significantl‐ compared with the mean value of LHRH throughout the pregnanc‐. The mean hCG levels in the maternal plasma were highest from the 8th to the 11th week of pregnanc‐ and decreased graduall‐. These data suggest that: i) the plasma LHRH levels during pregnanc‐ are not related to those of hCG, ii) the LHRH secretion from maternal h‐pothalamus ma‐ be suppressed, and iii) LHRH s‐nthesized in the placenta ma‐ be degraded when it enters the maternal circulation
Prelabor Status Evaluation and Course of Labor
Authors: Dhall K. , Grover V. , Mahendru S.K. 
Published: August 2010

AbstractData were collected prospectively on 146 patients admitted for induction of labour. The induction was by dilute oxytocin drip (up to 16 mu/min) in most cases. A pre‐induction scoring system was constructed using all possible factors of significance when inducing a patient. The predictive value of this scoring system (Raw Scoring System) and of the Bishop pelvic score were evaluated by multiple regression analysis and a new pelvic score for pre‐induction evaluation has been proposed taking into consideration the factors of significant importance only.