bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of involvement and use in multisite evaluations
Authors: Lawrenz Frances , King Jean A. , Ooms Ann 
Published: March 2011

AbstractA cross‐case analysis of four National Science Foundation (NSF) case studies identified both unique details and common themes related to promoting the use and influence of multisite evaluations. The analysis provided evidence of diverse evaluation use by stakeholders and suggested that people taking part in the multisite evaluations perceived their involvement differently from the more traditional view of participation in local evaluations. The study also highlighted the importance of attending to the following issues: the interface between the funder and local project staff; the life cycles of the program and its evaluation, as well as those of the local project and its individual staff; the details of who controls the projects; the many tensions that can exist between the goals of the large‐scale program and its smaller funded projects; the perceived quality of the evaluation and the evaluators; and the possibilities of community building and networking across projects. © Wiley Periodicals Inc., and the American Evaluation Association.
Building a community of evaluation practice within a multisite program
Authors: Goodyear Leslie K. 
Published: March 2011

AbstractNew and novel uses of evaluation processes and findings are possible when a community of practice develops as evaluation stakeholders participate in multisite evaluations in multiple ways. Developing such communities takes advantage of what makes multisite evaluations special. This chapter uses the example of the Innovative Technology Experiences for Students and Teachers Program's Learning Resource Center, funded by the National Science Foundation, to articulate how the provision of evaluation technical assistance to a large, multisite program and its funded projects can contribute to evaluation use. © Wiley Periodicals, Inc., and the American Evaluation Association.
Influence of decreased sample size on cone calorimeter results
Authors: Lindholm Johan , Brink Anders , Hupa Mikko 
Published: March 2011

SUMMARYCone calorimeter sample size sensitivity and the influence of sample size on the results were studied in order to investigate the possibility to use smaller samples than prescribed by the standard. The influence of the position of the sample on the sample holder of the decreased samples was also studied. Samples of birch plywood, industrial two‐component polyurethane adhesive and polypropylene wax were tested. The results from standard size sample experiments, 100 cm 2, and decreased sample size, 50 and 25 cm2, were compared, in order to investigate the sample size influence on the results. The experiments were performed using an external heat flux of 50kW/ m2. The results show differences between the sample types. The measured heat release rates for plywood and polyurethane adhesive indicate that the sample size is possible to down‐scale, while the polypropylene wax results show the opposite. All sample types and sizes show constant results for the effective heat of combustion, indicating down‐scalability. For in‐house testing and screening of materials, downscaling can be used for most sample types. However, results from experiments carried out with decreased sample size should not be compared to results from experiments executed according to the standard procedure. Copyright © 2011 John Wiley & Sons, Ltd.
Let‐7 MicroRNA and HMGA2 levels of expression are not inversely linked in adipocytic tumors: Analysis of 56 lipomas and liposarcomas with molecular cytogenetic data
Authors: Bianchini Laurence , Saâda Esma , Gjernes Elisabet , Marty Marion , Haudebourg Juliette , Birtwisle‐Peyrottes Isabelle , Keslair Frédérique , Chignon‐Sicard Bérangère , Chamorey Emmanuel , Pedeutour Florence 
Published: March 2011

AbstractThe aim of our study was first to assess the role of HMGA2 expression in the pathogenesis of adipocytic tumors (AT) and, second, to seek a potential correlation between overexpression of HMGA2 and let‐7 expression inhibition by analyzing a series of 56 benign and malignant AT with molecular cytogenetic data. We measured the levels of expression of HMGA2 mRNA and of eight members of the let‐7 microRNA family using quantitative RT‐PCR and expression of HMGA2 protein using immunohistochemistry. HMGA2 was highly overexpressed in 100% of well‐differentiated/dedifferentiated liposarcomas (WDLPS/DDLPS), all with HMGA2 amplification, and 100% of lipomas with HMGA2 rearrangement. Overexpression of HMGA2 mRNA was detected in 76% of lipomas without HMGA2 rearrangement. HMGA2 protein expression was detected in 100% of lipomas with HMGA2 rearrangement and 48% of lipomas without HMGA2 rearrangement. We detected decreased expression levels of some let‐7 members in a significant proportion of AT. Notably, let‐7b and let‐7g were inhibited in 61% of WDLPS/DDLPS. In lipomas, each type of let‐7 was inhibited in approximately one‐third of the cases. Although overexpression of both HMGA2 mRNA and protein in a majority of ordinary lipomas without HMGA2 structural rearrangement may have suggested a potential role for let‐7 microRNAs, we did not observe a significant link with let‐7 inhibition in such cases. Our results indicate that inhibition of let‐7 microRNA expression may participate in the deregulation of HMGA2 in AT but that this inhibition is neither a prominent stimulator for HMGA2 overexpression nor a surrogate to genomic HMGA2 rearrangements. © 2011 Wiley‐Liss, Inc.
Identification of intragenic deletions and duplication in the FLCN gene in Birt‐Hogg‐Dubé syndrome
Authors: Benhammou Jihane N. , Vocke Cathy D. , Santani Avni , Schmidt Laura S. , Baba Masaya , Seyama Kuniaki , Wu Xiaolin , Korolevich Susana , Nathanson Katherine L. , Stolle Catherine A. , Linehan W. Marston 
Published: March 2011

AbstractBirt‐Hogg‐Dubé syndrome (BHDS), caused by germline mutations in the folliculin (FLCN) gene, predisposes individuals to develop fibrofolliculomas, pulmonary cysts, spontaneous pneumothoraces, and kidney cancer. The FLCN mutation detection rate by bidirectional DNA sequencing in the National Cancer Institute BHDS cohort was 88%. To determine if germline FLCN intragenic deletions/duplications were responsible for BHDS in families lacking FLCN sequence alterations, 23 individuals from 15 unrelated families with clinically confirmed BHDS but no sequence variations were analyzed by real‐time quantitative PCR (RQ‐PCR) using primers for all 14 exons. Multiplex ligation‐dependent probe amplification (MLPA) assay and array‐based comparative genomic hybridization (aCGH) were utilized to confirm and fine map the rearrangements. Long‐range PCR followed by DNA sequencing was used to define the breakpoints. We identified six unique intragenic deletions in nine patients from six different BHDS families including four involving exon 1, one that spanned exons 2–5, and one that encompassed exons 7–14 of FLCN. Four of the six deletion breakpoints were mapped, revealing deletions ranging from 5688 to 9189 bp. In addition, one 1341 bp duplication, which included exons 10 and 11, was identified and mapped. This report confirms that large intragenic FLCN deletions can cause BHDS and documents the first large intragenic FLCN duplication in a BHDS patient. Additionally, we identified a deletion “hot spot” in the 5′‐noncoding‐exon 1 region that contains the putative FLCN promoter based on a luciferase reporter assay. RQ‐PCR, MLPA and aCGH may be used for clinical molecular diagnosis of BHDS in patients who are FLCN mutation‐negative by DNA sequencing. Published 2011 Wiley‐Liss, Inc.
Incorporating landscape features to obtain an object‐oriented landscape drainage network representing the connectivity of surface flow pathways over rural catchments
Authors: Gascuel‐Odoux Chantal , Aurousseau Pierre , Doray Thibaut , Squividant Hervé , Macary Francis , Uny Daniel , Grimaldi Catherine 
Published: March 2011

AbstractA topological representation of a rural catchment is proposed here in addition to the generally used topographic drainage network. This is an object‐oriented representation based on the identification of the inlets and outlets for surface water flow on each farmer's field (or plot) and their respective contributing areas and relationships. It represents the catchment as a set of independent plot outlet trees reaching the stream, while a given plot outlet tree represents the pattern of surface flow relationships between individual plots. In the present study, we propose to implement functions related to linear and surface elements of the landscape, such as hedges or road networks, or land use, to obtain what we call a landscape drainage network which delineates the effective contributing area to the stream, thus characterizing its topological structure. Landscape elements modify flow pathways and/or favour water infiltration, thus reducing the area contributing to the surface yield and modifying the structure of the plot outlet trees. This method is applied to a 4·4‐km2 catchment area comprising 43 955 pixels and 312 plots. While the full set of 164 plot outlet trees, with an average of 7 plots per tree, covers 100% of the total surface area of the catchment, the landscape drainage network comprises no more than 37 plot outlet trees with an average of 2 plots per tree, accounting for 52 and 7% of the catchment surface area, when taking account of linear elements and land use, respectively. This topological representation can be easily adapted to changes in land use and land infrastructure, and provides a simple and functional display for intercomparison of catchments and decision support regarding landscape and water management. Copyright © 2011 John Wiley & Sons, Ltd.
Investigation of the snow‐cover dynamics in the Upper Euphrates Basin of Turkey using remotely sensed snow‐cover products and hydrometeorological data
Authors: Akyurek Zuhal , Surer Serdar , Beser Özgür 
Published: March 2011

AbstractThe Euphrates and Tigris rivers serve as the most important water resources in the Middle East. Precipitation in this region falls mostly in the form of snow over the higher elevations of the Euphrates Basin and remains on the ground for nearly half of the year. This snow‐covered area (SCA) is a key element of the hydrological cycle, and monitoring the SCA is crucial for making accurate forecasts of snowmelt discharge, especially for energy production, flood control, irrigation, and reservoir‐operation optimization in the Upper Euphrates (Karasu) Basin. Remote sensing allows the detection of the spatio‐temporal patterns of snow cover across large areas in inaccessible terrain, such as the eastern part of Turkey, which is highly mountainous. In this study, a seasonal evaluation of the snow cover from 2000 to 2009 was performed using 8‐day snow‐cover products (MOD10C2) and the daily snow‐water equivalent (SWE) product. The values of SWE products were obtained using an assimilation process based on the Helsinki University of Technology model using equal area Special Sensor Microwave Imager (SSM/I) Earth‐gridded advanced microwave scanning radiometer—EOS daily brightness‐temperature values. In the Karasu Basin, the SCA percentage for the winter period is 80–90%. The relationship between the SCA and the runoff during the spring period is analysed for the period from 2004 to 2009. An inverse linear relationship between the normalized SCA and the normalized runoff values was obtained (r = 0·74). On the basis of the monthly mean temperature, total precipitation and snow depth observed at meteorological stations in the basin, the decrease in the peak discharges, and early occurrences of the peak discharges in 2008 and 2009 are due to the increase in the mean temperature and the decrease in the precipitation in April. Copyright © 2011 John Wiley & Sons, Ltd.
Host immune gene polymorphisms were associated with the prognosis of non‐small‐cell lung cancer in Chinese
Authors: Dai Juncheng , Hu Zhibin , Dong Jing , Xu Lin , Pan Shiyang , Jiang Yue , Jin Guangfu , Chen Yijiang , Shen Hongbing 
Published: March 2011

AbstractLaboratory‐based studies showed that host immune genes could influence the prognosis of non‐small‐cell lung cancer (NSCLC). Therefore, genetic polymorphisms in host immune genes may serve as predictors for NSCLC clinical outcome. To test the hypothesis that functional single nucleotide polymorphisms (SNPs) in host immune genes are associated with the prognosis of NSCLC, we systematically performed a genotyping analysis for a total of 178 SNPs from 52 immune genes in a prospective case cohort of 568 NSCLC patients. Among the 178 SNPs, 24 were significantly associated with NSCLC prognosis in different genetic models and four of them were remained in the final predictive model after multivariate stepwise Cox regression, including IL‐5R rs11713419 (5′‐untranslated region, 5′‐UTR) (P = 0.001), IL23R rs6682925 (5′‐flanking region, 5′‐FR) (P = 0.017), TLR1 rs5743551 (5′‐FR) (P = 0.02) and TLR3 rs3775291 (Leu412Phe) (P = 0.01). We then put the above four SNPs together, and found that the risk of death was significantly increased by 124% (HR = 2.24, 95% CI: 1.33–3.75) for the patients carrying “1” unfavorable locus and by 175% (HR = 2.75, 95% CI: 1.67–4.51) for those carrying “2‐4” unfavorable loci. The risk score model and time‐dependent ROC analyses further support the four SNPs and clinical risk score model. The area under curve (AUC) at year 5 increased from 0.484 to 0.831 after combining the four SNPs risk score with clinical risk score. These findings indicate that potentially functional polymorphisms in immune genes may serve as prognostic markers of clinical outcome of NSCLC.
Detection of α‐fetoprotein and glypican‐3 mRNAs in the peripheral blood of hepatocellular carcinoma patients by using multiple FQ‐RT‐PCR
Authors: Yan Dong , He Qingfang , Chen Yaping , Wang Lixin , Zhang Xinwei 
Published: March 2011

AbstractThis work aimed to investigate the correlation of the expression of α‐fetoprotein (AFP) and glypican‐3 (GPC3) mRNAs in the peripheral blood with primary hepatocellular carcinoma (HCC) and HCC metastasis by using multiple fluorescence quantitative reverse transcriptase‐polymerase chain reaction (FQ‐RT‐PCR). Peripheral blood samples from 100 patients with HCC were collected. The positive expression rates of AFP mRNA of HCC, hepatitis B, and cirrhosis patients were 56, 5, and 10%, respectively. AFP mRNA was not detected in healthy subjects, hepatic hemangioma, or hepatic metastasis patients' samples. Those of GPC3 mRNA of HCC patients were 76%. GPC3 mRNA was not detected in healthy subjects, hepatitis B, cirrhosis, hepatic hemangioma, or hepatic metastasis patients' samples. In HCC patients' samples, the combined positive rate of AFP and GPC3 mRNA expressions was 81%. The relative expression levels of GPC3 mRNA in the metastasis group and nonmetastasis group were 0.98±0.38 and 0.72±0.26, respectively, and showed significantly different (P=0.001). However, no significant difference was observed in the AFP mRNA expression levels (P=0.134). In conclusion, the sensitivity of HCC diagnosis can be improved by combined detection of AFP and GPC3 mRNA expressions. GPC3 mRNA is HCC‐specific, and may indicate HCC metastasis. J. Clin. Lab. Anal. 25:113–117, 2011. © 2011 Wiley‐Liss, Inc.
Postnatal variations in blood free and acylcarnitines
Authors: De Tanima , Kruthika‐Vinod T.P. , Nagaraja Dindagur , Christopher Rita 
Published: March 2011

AbstractBackground: Alteration in concentrations of blood carnitine and its esters are diagnostic of a number of inherited metabolic disorders. Acylcarnitine (AC) profiles of newborns obtained from dried blood spots by tandem mass spectrometric analysis are being used for the diagnosis of these disorders. There are no data of the postnatal variations of free carnitine (FC) and AC in Indian neonates. Objectives: Evaluation of postnatal variations in free and AC levels in newborns. Methods: Blood FC and AC levels were evaluated in 2,727 healthy neonates of postnatal day 2–30 by electrospray ionization tandem mass spectrometry. Results: Blood C2, C5DC, C16, C16:1, C18, C18:1, C18:2, and C18:OH carnitineswere increased in groups A (aged 8–14 days) and B (aged 15–30 days), compared with the control group (aged 2–7 days), whereas C3, C4, C4OH, C6, C6DC, and C12 carnitines were increased only in group B. No sex‐related differences were found except for C3DC, C4, and C5 carnitine concentrations, which were higher in female neonates. Conclusions: Our data can be used as a reference for the assessment of carnitine status in Indian newborns, hence reducing the risk of misdiagnosis of fatty acid oxidation disorders and organic acidemias during interpretation of the results of tandem mass spectrometry‐based newborn screening. J. Clin. Lab. Anal. 25:126–129, 2011. © 2011 Wiley‐Liss, Inc.
A case of coronary artery fistula diagnosed in the right decubitus position by transthoracic echocardiography
Authors: Araki Ryo , Abe Haruhiko , Adachi Hidenori , Umekawa Seiko , Hattori Susumu , Noda Yoshiki , Yasuoka Yoshinori , Sasaki Tatsuya 
Published: March 2011

AbstractA 70‐year‐old woman was admitted to our hospital for a continuous heart murmur in the fourth intercostal space at the right sternal border. Routine echocardiography demonstrated aneurismal dilatation at the origin of right coronary artery. These findings suggested a coronary artery fistula, although its drainage site could not be identified. By shifting the patient to the right decubitus position, we could observe an abnormal color Doppler signal going from the right coronary artery into the right atrium, confirming coronary artery fistula. The right decubitus position may be helpful for the evaluation of abnormal anatomic and auscultatory findings. © 2011 Wiley Periodicals, Inc. J Clin Ultrasound 2011.
Facile one‐pot synthesis of [1,2,4]triazolo[3,4‐b][1,3,4]thiadiazines and 3,7‐dimethyl‐4H‐[1,2,4]triazino[3,4‐b][1,3,4]thiadiazin‐6‐one using heteropolyacid catalysts
Authors: Motamedi Radineh , Monfared Aazam , Nezamabadi Zohre Ghahghai , Bamoharram Fatemeh F. 
Published: March 2011

Abstract[1,2,4]Triazolo[3,4‐b][1,3,4]thiadiazines 2a, 2b, 2c, 2d, 2e, 2f and 3,7‐dimethyl‐4H‐[1,2,4]triazino[3,4‐b][1,3,4]thiadiazin‐6‐one 4 were synthesized by one‐pot cyclocondensation reaction with α‐chloroacetonitrile and α‐haloketones in the presence of catalytic amounts of heteropolyacids in very high yields and rates. J. Heterocyclic Chem., (2011).
Regulation of tissue plasminogen activator/plasminogen activator inhibitor‐1 by hydrocortisone in rat primary astrocytes
Authors: Kwon Kyoung Ja , Cho Kyu Suk , Lee Sung Hoon , Kim Jung Nam , Joo So Hyun , Ryu Jong Hoon , Ignarro Louis J. , Han Seol‐Heui , Young Shin Chan 
Published: March 2011

AbstractAlthough originally known as a plasma serine protease involved in clot dissolution, tPA and its primary inhibitor, PAI‐1, play crucial roles in synaptic reorganization and plasticity in the central nervous system. In contrast to the wide array of work conducted in neural cells, relatively little is known about the regulatory mechanism governing tPA/PAI‐1 expression in astrocytes. Glucocorticoids (GCs) such as hydrocortisone regulate the expression of tPA/PAI‐1 in various biological systems in a tissue‐specific manner. However, little is known about GC‐mediated regulation of tPA/PAI‐1 system in CNS. The aims of the present study were to investigate whether tPA/PAI‐1 expression is regulated by hydrocortisone in rat primary astrocytes. Enzyme activity of tPA was decreased in a concentration‐dependent manner by hydrocortisone treatment, and the activity of PAI‐1 was increased by hydrocortisone. Hydrocortisone did not affect the level of tPA mRNA, which suggests that transcriptional down‐regulation of tPA mRNA is not involved in the down‐regulation of tPA enzyme activity in astrocytes. However, the level of PAI‐1 mRNA and protein was increased. Both hydrocortisone and a tPA‐Stop treatment prevented glutamate‐induced neurotoxicity in rat cortical primary mixed astrocyte–neuron culture, which suggests a neurotoxic role for tPA in our culture system. Interestingly, hydrocortisone further increased LPS‐induced up‐regulation of PAI‐1 while inhibiting the up‐regulation of iNOS and COX‐2 expression. Our data show that hydrocortisone up‐regulated PAI‐1 expression along with down‐regulation of tPA activity in both normal and inflammatory conditions. © 2011 Wiley‐Liss, Inc.
I owe you one: Coworker reciprocity as a moderator of the day‐level exhaustion–performance relationship
Authors: Halbesleben Jonathon R. B. , Wheeler Anthony R. 
Published: March 2011

AbstractThis research extends the literature on well‐being and performance behavior by looking at how daily fluctuations in employee exhaustion impact performance behaviors. Specifically, we tested a model based on conservation of resources theory (COR) where we predicted that daily fluctuations in exhaustion would be positively associated with organizational citizenship behaviors targeted at coworkers (OCB‐I) but negatively associated with in‐role performance and organizational citizenship behaviors targeted at the organization (OCB‐O); further, we predicted that these relationships would be stronger for employees who perceived a lack of reciprocity in their relationship such that they contributed less or gained more than their coworker (called positive inequity). In two studies including a total of 354 employees from a variety of industries over five time periods over the duration of a week, we found support for the positive relationship between exhaustion and OCB‐I, the negative relationships between of exhaustion and in‐role performance and OCB‐O, as well as the moderation effect of reciprocity. We discuss the implications of this finding for the manner in which employees strategically invest their resources in order to regain their well‐being. Copyright © 2011 John Wiley & Sons, Ltd.
Delayed gadolinium‐enhanced magnetic resonance imaging of cartilage (dGEMRIC) in Femoacetabular impingement
Authors: Mamisch Tallal Charles , Kain Micheal Sean Hillega , Bittersohl Bernd , Apprich Sebastian , Werlen Stefan , Beck Martin , Siebenrock Klaus Arno 
Published: March 2011

AbstractFemoroacetabular impingement is a well‐described pre‐arthritic condition with two main types; cam and pincer. Studies using the open treatment for impingement have described patterns of articular cartilage wear specific to cam and pincer impingement. Assessing articular damage in the hip joint is an important component of treatment. Intravenous gadolidium allows radiologists to perform an indirect assessment of articular cartilage glycosaminoglycan (GAG) content by using a technique called dGEMRIC. Using this indirect assessment of articular cartilage, we compared the dGEMRIC indices in a group of six cam and seven pincer patients to a control group (n = 12) of asymptomatic controls that had no plain MRI findings of osteoarthritis. The superior portion of the hip joint was divided into seven regions from 9 to 3 o'clock. These regions were then subdivided into peripheral and central regions. The cam and pincer groups both had statistically lower dGEMRIC values compared to the control group. The cam group demonstrated not only peripheral but also central involvement of the joint and this was concentrated in the anterior portion of the joint. The pincer group exhibited more global hip involvement with all areas of the hip averaging a dGEMRIC index 28% less than controls. With the use of dGEMRIC more specific patterns of cartilage wear can be elicited in patients with impingement, which may improve patient selection and help better understand the progression of osteoarthithis throughout the hip joint. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 29: 1305–1311, 2011