bluuebunny/crossref_metadata_2025_split huggingface dataset:
Involving Young Learners in Mind, Brain and Education Research
Authors: Massonnié Jessica , Tokuhama‐Espinosa Tracey , Fern‐Pollak Liory 
Published: May 2024

ABSTRACTFor two decades, the field of Mind, Brain and Education (MBE) has shed light on learning mechanisms. However, the direct involvement of young learners in the design and creation of research projects, while steadily emerging, is still rare. More researchers are beginning to see the benefits of co‐construction of not only research questions but also experimental design and analysis based on young learners' ideas. Recognizing that learning is inseparable from social relationships and well‐being, the papers in this special issue respond to two main questions: (1) Why co‐production? (2) How is co‐production achieved? We hope that this special issue will invite discussions about the different domains within MBE research in which learners' input and collaboration can be valuable. We invite readers to take into consideration the diversity of methods which are represented in this special issue to engage young learners and collect their perspectives.
A novel indirect ELISA for serodiagnosis of mucormycosis using antigens from Rhizopus arrhizus
Authors: Choudhary Hansraj , Kaur Harsimran , Singh Shreya , Singh Rachna , Muthu Valliappan , Verma Roshan , Rudramurthy Shivaprakash M. , Agarwal Ritesh , Jain Sanjay , Bal Amanjit , Ghosh Anup K. , Chakrabarti Arunaloke 
Published: May 2024

AbstractBackgroundDue to a delay in diagnosis by conventional techniques and high mortality, the development of a standardised and rapid non‐culture‐based technique is an unmet need in pulmonary, gastrointestinal, and disseminated forms of mucormycosis. Though limited studies have been conducted for molecular diagnosis, there are no established serologic tests for this highly fatal infection.ObjectiveTo develop and evaluate an indirect in‐house enzyme‐linked immunosorbent assay (ELISA) utilising antigens of Rhizopus arrhizus for detecting anti‐Rhizopus antibodies (IgG and IgM) in sera of patients with mucormycosis.MethodsWe extracted both secretory and mycelial Rhizopus antigens using standardised protocols. Bradford assay was used for protein quantification. We then standardised an indirect ELISA using R. arrhizus mycelial and secretory antigens (10.0 μg/mL in bicarbonate buffer pH 9.2) for detecting anti‐Rhizopus IgG and IgM antibodies in patient sera. We included patients with mucormycosis, other fungal infections, and healthy controls. Antibody index value (E‐value) was calculated for each patient sample.ResultsAsparagine broth culture filtrate utilising 85% ammonium sulphate salt fractionation and mycelial homogenate grown in yeast extract peptone dextrose (YPD) broth precipitated with trichloroacetic acid (TCA) yielded a large amount of good‐quality protein for the assay. We included 55 patients with mucormycosis (rhino‐orbito‐cerebral mucormycosis [ROCM, n = 39], pulmonary [n = 15], gastrointestinal [n = 1]), 24 with other fungal infections (probable aspergillosis [n = 14], candidiasis [n = 10]), and healthy controls (n = 16). The sensitivity of the antibody test for diagnosing mucormycosis ranged from 83.6–92.7% for IgG and 72.7–87.3% for IgM, with a specificity of 91.7–92.5% for IgG and 80–82.5% for IgM. The sera from patients with other fungal infections and healthy individuals did not show significant cross‐reactivity.ConclusionThe detection of anti‐Rhizopus IgG antibody performed significantly better in comparison to IgM‐based ELISA for diagnosing both ROCM (sensitivity of 84.6% vs. 69.2%) and pulmonary cases (86.6% vs. 80.0%). More extensive studies are required to confirm our findings.
A cerebellar ataxia patient harboring 229 pure GAA repeat units in FGF14 presenting with grip myotonia
Authors: Mori Yasuko , Miyatake Satoko , Kunieda Kenjiro , Yoshikura Nobuaki , Hayashi Yuichi , Higashida Kazuhiro , Kimura Akio , Koshimizu Eriko , Matsumoto Naomichi , Shimohata Takayoshi 
Published: May 2024

AbstractSpinocerebellar ataxia 27 B (SCA27B) is caused by the expansion of GAA repeats in the intron of the fibroblast growth factor 14 (FGF14) on chromosome 13 and is inherited dominantly. An 80‐year‐old male visited the hospital complaining of ataxic gait and harboring 229 pure GAA repeat units in the FGF14. Almost all the clinical features were similar to that of SCA27B. However, the patient initially presented with episodic grip myotonia, which has not been previously reported.
Strong habitat and seasonal phenology effects on the evolution of self‐compatibility, clonality and pollinator shifts in Lachenalia (Asparagaceae: Scilloideae)
Authors: Duncan Graham D. , Ellis Allan G. , Forest Félix , Verboom G. Anthony 
Published: May 2024

Summary

Plants employ a diversity of reproductive safeguarding strategies to circumvent the challenge of pollen limitation. Focusing on southern African Lachenalia (Asparagaceae: Scilloideae), we test the hypothesis that the evolution of reproductive safeguarding traits (self‐compatibility, autonomous selfing, bird pollination and clonal propagation) is favoured in species occupying conditions of low insect abundance imposed by critically infertile fynbos heathland vegetation and by flowering outside the austral spring insect abundance peak.

We trace the evolution of these traits and selective regimes on a dated, multi‐locus phylogeny of Lachenalia and assess their evolutionary associations using ordinary and phylogenetic regression.

Ancestral state reconstructions identify an association with non‐fynbos vegetation and spring flowering as ancestral in Lachenalia, the transition to fynbos vegetation and non‐spring flowering taking place multiple times. They also show that self‐compatibility, autofertility, bird pollination and production of multiple clonal offsets have evolved repeatedly.

Regression models suggest that bird pollination and self‐compatibility are selected for in fynbos and in non‐spring flowering lineages, with autofertility being positively associated with non‐spring flowering. These patterns support the interpretation of these traits as reproductive safeguarding adaptations under reduced insect pollinator abundance. We find no evidence to support the interpretation of clonal propagation as a reproductive safeguarding strategy.
Medication and supplement pharmacokinetic changes following bariatric surgery: A systematic review and meta‐analysis
Authors: Lajeunesse‐Trempe Fannie , Okroj Dominika , Ostarijas Eduard , Ramalho Alan , Tremblay Eve‐Julie , Llewellyn David , Harlow Chris , Chandhyoke Nikhil , Chew Nicholas W. S. , Vincent Royce P. , Tchernof Andre , Piché Marie‐Eve , Poirier Paul , Biertho Laurent , Morin Marie‐Philippe , Copeland Caroline S. , Dimitriadis Georgios K. 
Published: May 2024

SummaryObjectivesTo evaluate the impact of bariatric surgery on the pharmacokinetic (PK) parameters of orally administered medications and supplements.MethodsSystematic searches of bibliographic databases were conducted to identify studies. Pooled effect estimates from different surgical procedures were calculated using a random‐effects model.ResultsQuantitative data were synthesized from 58 studies including a total of 1985 participants. Whilst 40 medications and 6 supplements were evaluated across these studies, heterogeneity and missing information reduced the scope of the meta‐analysis to the following medications and supplements: atorvastatin, paracetamol, omeprazole, midazolam, vitamin D, calcium, zinc, and iron supplements. There were no significant differences in PK parameters post‐surgery for the drugs atorvastatin and omeprazole, and supplements calcium, ferritin, and zinc supplements. Paracetamol showed reduced clearance (mean difference [MD] = −15.56 L/hr, p = 0.0002, I2 = 67%), increased maximal concentration (MD = 6.90 μg/ml, p = 0.006, I2 = 92%) and increased terminal elimination half‐life (MD = 0.49 hr, p < 0.0001, I2 = 3%) post‐surgery. The remaining 36 medications and 2 supplements were included in a systematic review. Overall, 18 of the 53 drugs and supplements showed post‐operative changes in PK parameters.ConclusionThis study demonstrates heterogeneity in practice and could not reach conclusive findings for most PK parameters. Prospective studies are needed to inform best practice and enhance patient healthcare and safety following bariatric surgery.
Small nucleolar RNA host gene 5 plays a role in orthodontic tooth movement by inhibiting osteoclast differentiation
Authors: Feng Jingjing , Tan Anqi , Li Weiran , Zheng Yunfei 
Published: May 2024

AbstractBackground and ObjectivesThe alveolar bone remodelling promoted by reasonable mechanical force triggers orthodontic tooth movement (OTM). The generation of osteoclasts is essential in this process. However, the mechanism of mechanical force mediating osteoclast differentiation remains elusive. Small nucleolar RNA host gene 5 (SNHG5), which was reported to mediate the osteogenic differentiation of bone marrow mesenchymal stem cells in our previous study, was downregulated in human periodontal ligament cells (hPDLCs) under mechanical force. At the same time, the RANKL/OPG ratio increased. Based on this, we probed into the role of SNHG5 in osteoclast formation during OTM and the relevant mechanism.Materials and MethodsSNHG5 and the RANKL/OPG ratio under different compressive forces were detected by western blotting (WB) and qRT‐PCR. Impact of overexpression or knockdown of SNHG5 on osteoclast differentiation was detected by qRT‐PCR, WB and transwell experiments. The combination of SNHG5 and C/EBPβ was verified by RNA immunoprecipitation and RNA pull‐down assays. The expression of SNHG5 and osteoclast markers in gingiva were analysed by qRT‐PCR and the paraffin sections of periodontal tissues were used for histological analysis.ResultsCompressive force downregulated SNHG5 and upregulated the RANKL/OPG ratio in hPDLCs. Overexpression of SNHG5 inhibited RANKL's expression and osteoclast differentiation. SNHG5 combined with C/EBPβ, a regulator of osteoclast. The expression of SNHG5 in periodontal tissue decreased during OTM.ConclusionSNHG5 inhibited osteoclast differentiation during OTM, achieved by affecting RANKL secretion, which may provide a new idea to interfere with bone resorption during orthodontic treatment.
Salutogenesis intervention improves cardio‐cerebrovascular health in at‐risk office workers: A quasi‐experimental study
Authors: Moon Ji Hyun , Ryu Hosihn 
Published: May 2024

AbstractObjectiveCardio‐cerebrovascular disease is the major cause of work‐related deaths. Salutogenesis indicates individual differences in health levels occur owing to differences in the sense of coherence (SOC). A salutogenesis‐based intervention may promote cardio‐cerebrovascular health at work. This study examined the effects of a SOC promotion program based on salutogenesis.DesignQuasi‐experimental study.SampleFifty‐six office workers who were above the “low risk” of cardio‐cerebrovascular disease from two workplaces were included in the final analysis.MeasurementsData collected pre‐ and postintervention. To determine the intervention's effectiveness, repeated‐measures analysis of variance was used.InterventionThe intervention group was provided with the SOC promotion program, whereas the control group was provided with educational materials alone for 12 weeks.ResultsGeneralized resistance resources (GRRs; knowledge of cardio‐cerebrovascular disease prevention, stress‐coping strategies, and social support) and SOC significantly improved in the intervention group. The intervention group showed significant improvements in occupational stress, physical activity, dietary behavior, total cholesterol level, fasting glucose level, hemoglobin A1C level, body mass index, waist circumference, diastolic and systolic blood pressure, and cardio‐cerebrovascular risk.ConclusionsSystematic salutogenesis‐based SOC promotion programs should be established to enhance the cardio‐cerebrovascular health of office workers at‐risk of cardio‐cerebrovascular diseases.Trial RegistrationTrial Registration Number is KCT0007029. The date of registration is February 23, 2022.
State and politics in the transitional era of globalization: Twisting and turning toward authoritarian and hybrid regimes
Authors: Rahman Hafijur , Islam Md Saidul , Gounjaria Nageeb 
Published: May 2024

AbstractBeyond its discontented thesis, globalization has had a difficult time in the last few years, owing to the global financial crises of 2008–2009 when its vacuous premises and promises were widely contested for being an unfair deal. The recent rise of nationalist and populist movements across the West and the East, boosted by the COVID‐19 pandemic, now threatens its survival. However, globalization experts are largely divided in charting its future; while some predict the demise of the existing world order, others believe globalization will continue with some restructuring. By analyzing the global political dynamics and reviewing political and scholarly news and views, we argue that globalization is currently undergoing a transitional era with a new paradox—one characterized by the emergence of a multipolar world but with local identity and tradition‐based politics. The upshot is that the state with the border is re‐emerging alongside authoritarian and hybrid regimes.Related ArticlesKane, John, and Haig Patapan. 2010. “Recovering Justice: Political Legitimacy Reconsidered.” Politics & Policy 38(3): 589–610. https://doi.org/10.1111/j.1747‐1346.2010.00250.x.Quinn, Adam. 2007. “The Great Illusion: Chimeras of Isolationism and Realism in Post‐Iraq U.S. Foreign Policy.” Politics & Policy 35(3): 522–47. https://doi.org/10.1111/j.1747‐1346.2007.00071.x.Zaidi, Syed Muhammad Saad. 2021. “American Global Supremacy Under Threat? The Chinese Factor.” Politics & Policy 49(2): 502–28. https://doi.org/10.1111/polp.12402.
How does climate change risk affect energy poverty? International evidence
Authors: Chen Jinyu , Luo Xianfeng , Ding Qian 
Published: May 2024

AbstractBased on cross‐country data from 2002 to 2019, we explore the impact of climate change risk (CCR) on energy poverty (EP), and the moderating role in the CCR–EP nexus is also discussed. The empirical results suggest that CCR can exacerbate EP, especially for rural areas. Moderating effect analysis shows that financial development, technological innovation, and adaptation readiness can modify the negative impacts of CCR on EP to some extent. Moreover, the impact of CCR on EP is heterogeneous, demonstrating that CCR is more likely to exacerbate EP in countries with low economic development, low economic freedom, high carbon intensity, and the Africa region. Our findings emphasize the challenge of balancing EP alleviation with climate change response and provide the policy guidance to promote coordinated development of CCR management and energy supply security.
Fairness in markets and market experiments: insights from a field‐plus‐lab study and a failed replication
Authors: Engelmann Dirk , Friedrichsen Jana , Kübler Dorothea 
Published: May 2024

AbstractWe investigate how fairness in a laboratory experiment framed as a market exchange relates to preferences for fair trade products elicited before and at the end of the experiment. We collected two samples, 10 years apart. In the original sample, fairness in the market experiment measured by the willingness to buy at a higher price when higher wages are paid to the worker correlates both with the choice of a fair trade product and with the willingness to pay a positive fair trade premium. These correlations are not significant in the replication experiment, which indicates at best a weak relationship.
Pentecostalism and the (de)construction of ‘Otherness’: Experiences of black African students at a South African University
Authors: Gukurume Simbarashe 
Published: May 2024

AbstractDrawing on fieldwork conducted at a South African University, this qualitative study examines the lived experiences of black foreign students studying and living in South Africa. The study sought to understand the role that Pentecostalism plays in mediating the everyday experiences of black foreign students within and beyond the university campus spaces. A total of 30 student patrons from two Pentecostal churches were purposively sampled for the study. Data were collected using qualitative methods, including in‐depth interviews, participant observation, and informal conversations. Data were recorded, transcribed, and thematically analysed. The study findings revealed that for many African foreign students in South Africa, Pentecostalism mediated their sense of being on campus and allowed them to deal with the real and perceived social disarticulation fashioned by xenophobic terrains and attendant socio‐material anxieties. I assert that Pentecostal communities helped African foreign students to embed themselves and adjust to life on campus. These communities allowed them to forge convivial relationships and mutuality with fellow students and other Church members. Building on extant scholarly arguments and debates on Pentecostalism and student mobilities, I argue that Pentecostalism play(ed) a central role in the (de)construction of a sense of ‘Otherness’ through socio‐spiritual rituals including, sermons (the word), proselytisation and other social practices, albeit with varying degrees of success. Although Pentecostal networks strongly mediated black African foreign students' everyday navigation in precarious social spaces, the anxiety and the feeling of otherness are not completely removed.
Writing from a colonised English
Authors: Abad‐Jugo Cyan 
Published: May 2024

AbstractThis article argues for the validity of using English to express Philippine identities and realities. It is an exercise in substantiating what my father, Philippine poet Gémino H. Abad (and National Artist for Literature since 2022), has written in so many essays about the writing of our literature in and from and through English because: ‘We have our own way of feeling by which we then use this language called English. So that English is ours. We have colonized it too’ (Abad et al.). It accounts for a writer's possible journey or process, as I grapple with what my father means and consider how it might apply in my own writing, particularly in Salingkit: A 1986 diary, set during the EDSA Revolution, and Letters from Crispin, set during both the Philippine Revolution and the EDSA Revolution. In writing these books in and from and through English, I affirm that English becomes less the language of subjugation, and more the language of liberation.
Translanguaging in multilingual elementary classrooms in the Philippines
Authors: Reyes Robin Atilano De Los 
Published: May 2024

AbstractThis article attempts to describe the translanguaging practices of third‐grade teachers and learners during English language teaching and learning, as well as the patterns and purposes the practices seek to achieve. Using nonparticipatory classroom observations, the study found that the participants produced at least three patterns where three languages were involved, and these patterns seem to allow learners to maximize their linguistic resources in discussions, in accomplishing assessment mechanisms and in keeping them on track for better understanding. With this, the study recommends legitimizing the said practice as it is not only consistent with multilinguals’ use of languages but also pedagogically beneficial for learning another language such as English.
Maximal Aerobic Power, Quality of Life, and Ejection Fraction in Survivors of Childhood Cancer Treated with Anthracyclines
Authors: Martínez Tagle Maritza , Loeza Magaña Pavel , Benito Reséndiz Alma Edith , Lucatero Lecona Iliana , Arreguín González Farina Esther , Chávez Delgado Alberto 
Published: May 2024

Background: Anthracycline-induced cardiotoxicity is a frequent complication that can occur at any stage of treatment, even in survivors. Objective: To determine maximum aerobic power, quality of life, and left ventricular ejection fraction in childhood cancer survivors treated with anthracyclines. Design: Cross-sectional, observational study. Methods: The left ventricular ejection fraction was obtained from the transthoracic echocardiogram report in the medical records. Each patient underwent a 6-minute walk test, assessment of maximum aerobic power on a cycle ergometer, and evaluation of perceived exertion using the EPInfant scale, and finally, their quality of life was evaluated using the pediatric quality of life inventory model. Results: A total of 12 patients were studied, with an average of 16.2 years of age. All patients exhibited a left ventricular ejection fraction >60%, the mean distance covered in the 6-minute walk test was 516.7 m, and the mean of the maximum aerobic power was 70 W. Low quality of life scores were obtained in the physical and psychosocial aspects. In the Pearson test, a weak correlation without statistical significance was found between all the variables studied. Conclusions: Simultaneously with the detection of cardiotoxicity in childhood cancer survivors, it is pertinent to perform physical evaluations as physical condition and cardiotoxicity seem to be issues that are not necessarily dependent.
Comprehensive lipidomic analysis of the genus
Cutibacterium
Authors: Chudzik Anna , Bromke Mariusz A. , Gamian Andrzej , Paściak Mariola 
Published: May 2024

ABSTRACT

Cutibacterium
are part of the human skin microbiota and are opportunistic microorganisms that become pathogenic in immunodeficient states. These lipophilic bacteria willingly inhabit areas of the skin where sebaceous glands are abundant; hence, there is a need to thoroughly understand their metabolism. Lipids are no longer considered only structural elements but also serve as signaling molecules and may have antigenic properties. Lipidomics remains a major research challenge, mainly due to the diverse physicochemical properties of lipids. Therefore, this study aimed to perform a large comparative lipidomic analysis of eight representatives of the
Cutibacterium
genus, including four phylotypes of
C. acnes
and two strains of
C. granulosum
,
C. avidum
, and
C. namnetense
. Lipidomic analysis was performed by liquid chromatography‒mass spectrometry (LC-MS) in both positive and negative ion modes, allowing the detection of the widest range of metabolites. Fatty acid analysis by gas chromatography‒mass spectrometry (GC-MS) corroborated the lipidomic data. As a result, 128 lipids were identified, among which it was possible to select marker compounds, some of which were characteristic even of individual
C. acnes
phylotypes. These include phosphatidylcholine PC 30:0, sphingomyelins (SM 33:1, SM 35:1), and phosphatidylglycerol with an alkyl ether substituent PG O-32:0. Moreover, cardiolipins and fatty acid amides were identified in
Cutibacterium
spp. for the first time. This comparative characterization of the cutibacterial lipidome with the search for specific molecular markers reveals its diagnostic potential for clinical microbiology.

IMPORTANCE

Cutibacterium
(previously
Propionibacterium
) represents an important part of the human skin microbiota, and its role in clinical microbiology is growing due to opportunistic infections. Lipidomics, apart from protein profiling, has the potential to prove to be a useful tool for defining the cellular fingerprint, allowing for precise differentiation of microorganisms. In this work, we presented a comparative analysis of lipids found in eight strains of the genus
Cutibacterium
, including a few
C. acnes
phylotypes. Our results are one of the first large-scale comprehensive studies regarding the bacterial lipidome, which also enabled the selection of
C. acnes
phylotype-specific lipid markers. The increased role of lipids not only as structural components but also as diagnostic markers or potential antigens has led to new lipid markers that can be used as diagnostic tools for clinical microbiology. We believe that the findings in our paper will appeal to a wide range of researchers.