bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unilateral or bilateral V-Y fasciocutaneous flaps for the coverage of soft tissue defects following total knee arthroplasty
Authors: Papaioannou Konstantinos , Lallos Stergios , Mavrogenis Andreas , Vasiliadis Elias , Savvidou Olga , Efstathopoulos Nikolaos 
Published: November 2010

Abstract

Background
Soft tissue necrosis following total knee arthroplasty (TKA) may be the cause of the devastating complication of deep infection. It necessitates an immediate operative intervention because it could potentially jeopardise the arthroplasty or even the limb.

Methods
Sixteen consecutive patients with a mean age of 73,8 years (range 47 to76 years) over a 6-year period (January 2003 to December 2008) with wound dehiscence after TKA were enrolled in the present study. Unilateral or bilateral fasciocutaneous V-Y flaps that are differently oriented, depending on the local conditions of the tissues were used to reconstruct the soft tissues defects.

Results
In 15 of the 16 cases studied, the wound was successfully covered with the presented technique while in 1 patient a partial flap loss occurred, which was healed after surgical debridement and the application of vacuum system. No other complications occurred. Knee prosthesis was salvaged in all the patients with a good functional and esthetical outcome.

Conclusions
The presented reconstructive technique is a simple, quick, versatile and reliable solution for the coverage of soft tissue defects following TKA, more than 2 cm width and grade 1 and 2 according to Laing classification, provided the V-Y flaps are applied early in the postoperative period and no complex defects are involved.
Sex-specific modification of progesterone receptor expression by 17β-oestradiol in human cardiac tissues
Authors: Kararigas Georgios , Becher Eva , Mahmoodzadeh Shokoufeh , Knosalla Christoph , Hetzer Roland , Regitz-Zagrosek Vera 
Published: November 2010

Abstract

Background
Although circulating levels of sexual hormones in elderly men and women are low and quite similar, the adaptation of the elderly heart to stress differs between the sexes. We have hypothesized that the effects of sexual hormones in the heart may differ in men and women. Here, we assessed whether 17β-oestradiol regulates gene expression in the human heart in a sex-dependent manner. We selected the progesterone receptor as a well studied 17β-oestradiol target that may be pathologically linked to cardiac remodelling.

Methods
In order to assess the ex vivo effects of 17β-oestradiol in intact human cardiac tissues, we developed a 24-h model for the culture of human atrial myocardium. We verified tissue viability after 24 h in culture with two standard assays to determine the degree of apoptosis and metabolic activity of cardiac tissues. Progesterone receptor mRNA and protein level were measured after 24-h treatment of tissues with 17β-oestradiol. Statistical analysis was performed by the Mann-Whitney U test and two-way ANOVA.

Results
We established a tissue culture model that allows for the study of viable human cardiac tissue over a 24-h period. After 24 h, cultured cardiac tissues revealed low apoptosis, retained their metabolic activity and, therefore, remained viable. Treatment with 17β-oestradiol led to an induction of the progesterone receptor mRNA level in female (P = 0.001) but not in male tissues. Similarly, there was an increase in the level of progesterone receptor protein in female tissues (P = 0.03), while a decreasing trend was observed in male tissues (P = 0.079) exposed to 17β-oestradiol.

Conclusions
Our novel finding may offer a molecular explanation for the sex-specific differences observed in cardiac remodelling. The culture model we established for human cardiac tissue will facilitate the study of cellular processes in health and disease and will be of use for pharmacological testing.
Collaborative effects of bystander-initiated cardiopulmonary resuscitation and prehospital advanced cardiac life support by physicians on survival of out-of-hospital cardiac arrest: a nationwide population-based observational study
Authors: Yasunaga Hideo , Horiguchi Hiromasa , Tanabe Seizan , Akahane Manabu , Ogawa Toshio , Koike Soichi , Imamura Tomoaki 
Published: November 2010

Abstract
Introduction
There are inconsistent data about the effectiveness of prehospital physician-staffed advanced cardiac life support (ACLS) on the outcomes of out-of-hospital cardiac arrest (OHCA). Furthermore, the relative importance of bystander-initiated cardiopulmonary resuscitation (BCPR) and ACLS and the effectiveness of their combination have not been clearly demonstrated.

Methods
Using a prospective, nationwide, population-based registry of all OHCA patients in Japan, we enrolled 95,072 patients whose arrests were witnessed by bystanders and 23,127 patients witnessed by emergency medical service providers between 2005 and 2007. We divided the bystander-witnessed arrest patients into Group A (ACLS by emergency life-saving technicians without BCPR), Group B (ACLS by emergency life-saving technicians with BCPR), Group C (ACLS by physicians without BCPR) and Group D (ACLS by physicians with BCPR). The outcome data included 1-month survival and neurological outcomes determined by the cerebral performance category.

Results
Among the 95,072 bystander-witnessed arrest patients, 7,722 (8.1%) were alive at 1 month, including 2,754 (2.9%) with good performance and 3,171 (3.3%) with vegetative status or worse. BCPR occurred in 42% of bystander-witnessed arrests. In comparison with Group A, the rates of good-performance survival were significantly higher in Group B (odds ratio (OR), 2.23; 95% confidence interval, 2.05 to 2.42; P < 0.01) and Group D (OR, 2.80; 95% confidence interval, 2.28 to 3.43; P < 0.01), while no significant difference was seen for Group C (OR, 1.18; 95% confidence interval, 0.86 to 1.61; P = 0.32). The occurrence of vegetative status or worse at 1 month was highest in Group C (OR, 1.92; 95% confidence interval, 1.55 to 2.37; P < 0.01).

Conclusions
In this registry-based study, BCPR significantly improved the survival of OHCA with good cerebral outcome. The groups with BCPR and ACLS by physicians had the best outcomes. However, receiving ACLS by physicians without preceding BCPR significantly increased the number of patients with neurologically unfavorable outcomes.
Minireview: Steroid Receptor Coactivator-3: A Multifarious Coregulator in Mammary Gland Metastasis
Authors: Lydon John P. , O'Malley Bert W. 
Published: November 2010

Abstract
A member of the steroid receptor coactivator (SRC)/p160 family, SRC-3 acts as a coregulator for nuclear receptor (NR) and non-NR transcription factors. Such coregulator pleiotropy enables SRC-3 to influence a myriad of signaling networks that are essential for normal physiology and pathophysiology. Although SRC-3’s proliferative role in primary tumor formation in the mammary gland is well established, a role for this oncogenic coregulator in tumor cell motility and invasion has only recently been elucidated. In the nucleus, SRC-3 is required for the execution of the epithelial–mesenchymal transition, a programming step which endows an immotile cancer cell with motile and invasive characteristics. Nuclear SRC-3 is also essential for proteolytic breakdown of the extracellular matrix by matrix-metalloproteinases, a process which enables primary tumor cell invasion into the surrounding stroma. At the plasma membrane, however, a truncated isoform of SRC-3 (SRC-3Δ4) serves as a signaling adaptor for the epidermal growth factor→focal adhesion kinase→c-Src signal transduction pathway, a signaling cascade that is central to growth factor–induced cell migration and invasion. Together, these studies underscore a pivotal role for SRC-3 not only as a proto-oncogene but also as a prometastatic factor during the early steps in the invasion-metastasis cascade. Beyond furnishing critical mechanistic insights into SRC-3’s involvement in mammary tumor progression, these findings provide opportunities to develop new approaches for breast cancer diagnosis and intervention.
Endocrine and Nutritional Management of the Post-Bariatric Surgery Patient: An Endocrine Society Clinical Practice Guideline
Authors: Heber David , Greenway Frank L. , Kaplan Lee M. , Livingston Edward , Salvador Javier , Still Christopher 
Published: November 2010

Objective: We sought to provide guidelines for the nutritional and endocrine management of adults after bariatric surgery, including those with diabetes mellitus. The focus is on the immediate postoperative period and long-term management to prevent complications, weight regain, and progression of obesity-associated comorbidities. The treatment of specific disorders is only summarized.Participants: The Task Force was composed of a chair, five additional experts, a methodologist, and a medical writer. It received no corporate funding or remuneration.Conclusions: Bariatric surgery is not a guarantee of successful weight loss and maintenance. Increasingly, patients regain weight, especially those undergoing restrictive surgeries such as laparoscopic banding rather than malabsorptive surgeries such as Roux-en-Y bypass. Active nutritional patient education and clinical management to prevent and detect nutritional deficiencies are recommended for all patients undergoing bariatric surgery. Management of potential nutritional deficiencies is particularly important for patients undergoing malabsorptive procedures, and strategies should be employed to compensate for food intolerance in patients who have had a malabsorptive procedure to reduce the risk for clinically important nutritional deficiencies. To enhance the transition to life after bariatric surgery and to prevent weight regain and nutritional complications, all patients should receive care from a multidisciplinary team including an experienced primary care physician, endocrinologist, or gastroenterologist and consider enrolling postoperatively in a comprehensive program for nutrition and lifestyle management. Future research should address the effectiveness of intensive postoperative nutritional and endocrine care in reducing morbidity and mortality from obesity-associated chronic diseases.
Increased Postprandial GIP and Glucagon Responses, But Unaltered GLP-1 Response after Intervention with Steroid Hormone, Relative Physical Inactivity, And High-Calorie Diet in Healthy Subjects
Authors: Hansen Katrine B. , Vilsbøll Tina , Bagger Jonatan I. , Holst Jens J. , Knop Filip K. 
Published: November 2010

abstractObjective:Increased postprandial glucose-dependent insulinotropic polypeptide (GIP) and glucagon responses and reduced postprandial glucagon-like peptide-1 (GLP-1) responses have been observed in some patients with type 2 diabetes mellitus. The causality of these pathophysiological traits is unknown. We aimed to determine the impact of insulin resistance and reduced glucose tolerance on postprandial GIP, GLP-1, and glucagon responses in healthy subjects.Research Design and Methods:A 4-h 2200 KJ-liquid meal test was performed in 10 healthy Caucasian males without family history of diabetes [age, 24 ± 3 yr (mean ± sd); body mass index, 24 ± 2 kg/m2; fasting plasma glucose, 4.9 ± 0.3 mm; hemoglobin A1c, 5.4 ± 0.1%] before and after intervention using high-calorie diet, relative physical inactivity, and administration of prednisolone (37.5 mg/d) for 12 d.Results:The intervention resulted in insulin resistance according to the homeostatic model assessment [1.1 ± 0.3 vs. 2.3 (mean ± sem) ± 1.3; P = 0.02] and increased postprandial glucose excursions [area under curve (AUC), 51 ± 28 vs. 161 ± 32 mm · 4 h; P = 0.045], fasting plasma insulin (36 ± 3 vs. 61 ± 6 pm; P = 0.02), and postprandial insulin responses (AUC, 22 ± 6 vs. 43 ± 13 nm · 4 h; P = 0.03). This disruption of glucose homeostasis had no impact on postprandial GLP-1 responses (AUC, 1.5 ± 0.7 vs. 2.0 ± 0.5 nm · 4 h; P = 0.56), but resulted in exaggerated postprandial GIP (6.2 ± 1.0 vs. 10.0 ± 1.3 nm · 4 h; P = 0.003) and glucagon responses (1.6 ± 1.5 vs. 2.4 ± 3.2; P = 0.007).Conclusions:These data suggest that increased postprandial GIP and glucagon responses may occur as a consequence of insulin resistance and/or reduced glucose tolerance. Our data suggest that acute disruption of glucose homeostasis does not result in reduced postprandial GLP-1 responses as observed in some individuals with type 2 diabetes mellitus.
Progressively promoting metacognition in a case of obsessive‐compulsive personality disorder treated with metacognitive interpersonal therapy
Authors: Dimaggio Giancarlo , Carcione Antonino , Salvatore Giampaolo , Nicolò Giuseppe , Sisto Antonella , Semerari Antonio 
Published: November 2010

Background. Many persons with personality disorders (PD) have problems contemplating mental states and using psychological knowledge to cope with their suffering and solve social problems, the skill termed metacognition in this article. Therapists can focus on metacognitive dysfunctions in order to tailor PD treatment to clients' metacognitive skills. Aims. To briefly summarize procedures for promoting clients' abilities to define problems in mentalistic terms and use this knowledge to develop new paths towards living an adapted social life, within the context of a continuous regulation of the therapy relationship. Method. Qualitative analysis of session transcript excerpts from a good‐outcome case treated with metacognitive interpersonal therapy. Conclusion. A therapeutic focus on metacognitive dysfunctions and a regulation of the therapy relationship can lead to improvements in symptoms and interpersonal functioning. The possibility of generalizing the procedure and testing it empirically is discussed.
Clients' experience of the process of change in cognitive analytic therapy
Authors: Rayner Kate , Thompson Andrew R. , Walsh Sue 
Published: November 2010

Objectives. Formulation is argued to be of central importance in most psychotherapeutic approaches, yet little is known about client's experience of this. This study sought to explore the client experience of receiving cognitive analytic therapy (CAT). It aims to gain a better understanding of the use of specific CAT tools (e.g., reformulation letters and diagrams) and how these tools relate to clients' understanding of change. Design. Grounded theory methodology utilizing a three‐stage analysis process was used to explore client's retrospective accounts of change in CAT. Methods. Fifteen semi‐structured interviews were conducted with nine participants who had received CAT. Data analysis involved initial coding of transcripts and further theoretical sampling and interviewing followed. This led to the production of a model that was then taken to three further participants for exploration in further interviews. An audit was conducted of the analysis process. Results. A core conceptual framework of ‘doing with’ the therapist emerged from the analysis and represented clients' experience of receiving CAT and participating in the reformulation process. This framework subsumed four interrelated themes; ‘being with the therapist’, ‘keeping it real’, ‘understanding and feeling’, and ‘CAT tools’. Conclusions. CAT was seen as an active and emotional experience facilitated by a trusting and collaborative therapeutic relationship. The CAT reformulation was seen as important but only when embedded within this context. Whilst, this was a small study theoretical generalizations are discussed about the process of change and further clinical and research recommendations are presented.
Echi del Romanzo e di Procopio di Gaza in Filagato Cerameo
Authors: Corcella Aldo 
Published: November 2010

Abstract
The real extension of Philagathus Cerameus' classical culture has been variously discussed. The homilies of this 12th century preacher from Southern Italy show a thorough knowledge of Heliodorus' Aethiopics (which, by the way, corroborates his identification with the author of the Commentatio in Charicleam). In hom. 24 Rossi Taibbi, on the other side, Philagathus appears to be drawing on Procopius of Gaza's Monody on Antioch, as is suggested by some fragments preserved in the lexicon περὶ συντάξεωζ. This confirms that he was especially acquainted with those ancient authors who were proposed as models in the rhetorical schools of the Comnenian age.
Proposte di Correzioni al Testo dei Nuovi ‘Morceaux Choisis’ di Michele Psello
Authors: Guida Augusto 
Published: November 2010

Abstract
New quotations recently published by P. Canart from a Vatican manuscript and identified as texts of Michael Psellos are examined, textual corrections and interpretations are proposed and further parallels presented that confirm the Psellian authorship put forward by the editor.
Niketas Stethatos der „Beherzte“?
Authors: Hinterberger Martin 
Published: November 2010

Abstract
According to a well-established opinion, the theological writer Niketas Stethatos († ca 1090) had received his surname “the Brave” due to his courageous criticism of the amorous adventures of Constantine IX. In fact, Stethatos is a family name and means “with a broad chest”.
Anastasius of Sinai: Biblical Scholar
Authors: Kuehn Clement 
Published: November 2010

Abstract
Anastasius of Sinai (Anastasius Sinaïta) is best known as a seventh century monk, theologian, and presbyter, whose writings defended the Chalcedonian creed, explored the union of God and humanity, and supported his congregation's faith after the Moslem invasion of Egypt. His Hexaemeron reveals yet another facet of his work: that of biblical scholarship. In this extensive commentary on the creation account of Genesis, Anastasius compares and discusses several Greek translations of the biblical text. Thus he becomes for us an important source of information about the Septuagint and other Greek translations of the Bible circulating during the Byzantine Period, especially those incorporated by Origen into the Hexapla. The Hexaemeron also raises some possibilities about the early library at Sinai and invites a comparison with the famous Codex Sinaïticus.
Detailed phonetic memory for multi-word and part-word sequences
Authors: Wade Travis , Möbius Bernd 
Published: November 2010

AbstractHumans recognize previously heard spoken words better when repetitions of the words involve identical productions than productions by a different speaker. Such findings have been taken as evidence that perceived instances of words or sub-lexical units are stored in a detailed form in memory, and that collections of these memory traces comprise or are linked to mental lexical representations. This study tested a different possibility, that detailed acoustic memory occurs during spoken language processing but does not necessarily correspond to words or other traditionally defined units. Two experiments examined lexical access and recognition memory for continuous speech sequences, extracted from a spoken language corpus, as a function of sequence length and onset phase (with respect to word onset), and speaker. Qualitatively different patterns between word identification and memory performance based on these three variables provide little evidence for a role of the word level of representation in memory for the sequences, and suggest that memory-based processing may more independent of this level than has been assumed.
The emergent paradigm in Laboratory Phonology: Phonological categories and statistical generalisation in Cutler, Beckman and Edwards, Frisch and Bréa-Spahn, Kapatsinski, and Walter
Authors: Croot Karen 
Published: November 2010

AbstractThis commentary responds to Abigail Cohn's review of successes and challenges in Laboratory Phonology at the LabPhon10 meeting in 2006 (Cohn, Laboratory Phonology: Past successes and current questions, challenges and goals, Mouton de Gruyter, 2010), and her call for “truly integrated” theoretical models. In my view, the sort of integrated theory that Cohn endorsed relies on the availability of a scientific paradigm to organise our approach to data, methodology and theory. I propose that, from its codification as an approach by the first LabPhon meeting in 1987 (Beckman and Kingston, Introduction, Cambridge University Press, 1990), research in Laboratory Phonology has been (and still is) in the process of acquiring such a paradigm. My commentary argues that the occurrence of categorisation at various levels of granularity, together with evidence for gradient category membership at all levels, are central findings in Laboratory Phonology. These sit in the paradigm alongside the core research question about how the physical, cognitive and social properties of speech sounds are related, and a commitment to using hybrid methodologies from phonetics and phonology, computational linguistics, psycholinguistics and sociolinguistics. My commentary highlights these aspects of the emerging LabPhon paradigm in the papers in this issue by Cutler, Beckman and Edwards, Frisch and Bréa-Spahn, Kapatsinski, and Walter.
Signal-based and expectation-based factors in the perception of prosodic prominence
Authors: Cole Jennifer , Mo Yoonsook , Hasegawa-Johnson Mark 
Published: November 2010

AbstractThe perception of prosodic prominence in spontaneous speech is investigated through an online task of prosody transcription using untrained listeners. Prominence is indexed through a probabilistic prominence score assigned to each word based on the proportion of transcribers who perceived the word as prominent. Correlation and regression analyses between perceived prominence, acoustic measures and measures of a word's information status are conducted to test three hypotheses: (i) prominence perception is signal-driven, influenced by acoustic factors reflecting speakers' productions; (ii) perception is expectation-driven, influenced by the listener's prior experience of word frequency and repetition; (iii) any observed influence of word frequency on perceived prominence is mediated through the acoustic signal. Results show correlates of perceived prominence in acoustic measures, in word log-frequency and in the repetition index of a word, consistent with both signal-driven and expectation-driven hypotheses of prominence perception. But the acoustic correlates of perceived prominence differ somewhat from the correlates of word frequency, suggesting an independent effect of frequency on prominence perception. A speech processing account is offered as a model of signal-driven and expectation-driven effects on prominence perception, where prominence ratings are a function of the ease of lexical processing, as measured through the activation levels of lexical and sub-lexical units.
Resistance simulations for junctions of SW and MW carbon nanotubes with various metal substrates
Authors: Shunin Yuri , Zhukovskii Yuri , Burlutskaya Natalia , Bellucci Stefano 
Published: November 2010

Abstract
This theoretical study focuses on junctions between the carbon nanotubes (CNTs) and contacting metallic elements of a nanocircuit. Numerical simulations on the conductance and resistance of these contacts have been performed using the multiple scattering theory and the effective media cluster approach. Two models for CNT-metal contacts have been considered in this paper: a) first principles “liquid metal” model and b) semi-empirical model of “effective bonds” based on Landauer notions on ballistic conductivity. Within the latter, which is a more adequate description of chirality effects, we have simulated both single-wall (SW) and multi-wall (MW) CNTs with different morphology. Results of calculations on resistance for different CNT-Me contacts look quantitatively realistic (from several to hundreds kOhm, depending on chirality, diameter and thickness of MW CNT). The inter-wall transparency coefficient for MW CNT has been also simulated, as an indicator of possible ‘radial current’ losses.