bluuebunny/crossref_metadata_2025_split huggingface dataset:
IDOAKE: strongly secure ID‐based one‐pass authenticated key exchange protocol
Authors: Huang Hai , Cao Zhenfu 
Published: December 2010

AbstractID‐based one‐pass authenticated key exchange protocol allows the sender Alice to generate a session key without interacting with receiver Bob. As a result, it is better suitable for some application scenarios than the two‐pass counterpart. However, currently there are few ID‐based one‐pass authenticated key exchange protocols with a security proof in a formal model. The paper investigates the ID‐based one‐pass authenticated key exchange protocol in the enhanced Canetti–Krawczyk (eCK) model. We propose a new ID‐based one‐pass authenticated key exchange protocol IDOAKE, which is shown secure under Bilinear Diffie–Hellman (BDH) assumption in the eCK model. To the best of our knowledge, our protocol is the first provably secure ID‐based one‐pass authenticated key exchange in the eCK model. Copyright © 2010 John Wiley & Sons, Ltd.
A game theoretic investigation of deception in network security
Authors: Carroll Thomas E. , Grosu Daniel 
Published: December 2010

AbstractWe perform a game theoretic investigation of the effects of deception on the interactions between an attacker and a defender of a computer network. The defender can employ camouflage by either disguising a normal system as a honeypot or by disguising a honeypot as a normal system. We model the interactions between defender and attacker using a signaling game, a non‐cooperative two player dynamic game of incomplete information. For this model, we determine which strategies admit perfect Bayesian equilibria. These equilibria are refined Nash equilibria in which neither the defender nor the attacker will unilaterally choose to deviate from their strategies. We discuss the benefits of employing deceptive equilibrium strategies in the defense of a computer network. Copyright © 2010 John Wiley & Sons, Ltd.
A self‐stabilized random access protocol against denial of service attack in wireless networks
Authors: Sarker Jahangir H. , Mouftah Hussein T. 
Published: December 2010

AbstractOne of the main drawbacks of Slotted ALOHA is its throughput collapse at higher traffic load condition due to excessive collisions and known as stability problem. A random packet destruction Denial of Service (DoS) attack can increase the throughput collapse by increasing the collisions further. The current security protection techniques such as encryption, authentication and authorization cannot prevent these types of attacks, since the attacking packets destroy those packets by colliding those encrypted, authenticated and authorized packets. The maximum throughput of Slotted ALOHA can be achieved by the knowledge of the number of active mobile nodes and the average rate of the attacking packet arrival rate. However, the knowledge of these two parameters' current values are difficult and sometimes impossible to know. A self‐stabilized Slotted ALOHA system against the random packet destruction attacking noise packets is presented in this paper. Results show that the system provides nearly optimal stable throughput without the knowledge of current active number of mobile nodes and current attacking packets arrival rate. The proposed system is truly distributive in nature and can be easily implemented in wireless access systems without requiring any centralized control and can defend against random packet destruction DoS attack. Copyright © 2010 John Wiley & Sons, Ltd.
Anonymity notions and techniques for public‐key infrastructures in vehicular networks
Authors: Di Crescenzo G. , Zhang T. , Pietrowicz S. 
Published: December 2010

AbstractAs vehicular networks approach deployment phases, there is wide recognition for challenges and pressing needs for solutions with respect to the areas of security, privacy, and performance. The requirement of participation in applications such as traffic safety, combined with the intrinsically ad hoc network environment, poses rather novel challenges to the modeling, design, and analysis of security solutions for vehicular networks. One particularly stringent requirement in this area is that of protecting the privacy of vehicle owners (i.e., their anonymity and their vehicle's location unlinkability) during their participation in a vehicular network such as in traffic safety applications. In this paper, we present novel models of concrete anonymity and unlinkability requirements for vehicular networks that can be built using state‐of‐the‐art options for communication network deployment (e.g., road‐side short‐range radio networks and hotspot networks). One key aspect of our modeling consists of recognizing the existence and impact of additional certification authorities managed by vehicle manufacturers. In particular, we consider a simple variant of a previously proposed public‐key infrastructure (PKI) for vehicular networks and present two techniques to augment it so that it provides improved anonymity and unlinkability properties. The resulting vehicular‐network key infrastructures satisfy desirable combinations of anonymity, unlinkability, bad actor detection, and performance requirements. Copyright © 2010 John Wiley & Sons, Ltd.
Bootstrap confidence intervals and bias correction in the estimation of HIV incidence from surveillance data with testing for recent infection
Authors: Carnegie Nicole Bohme 
Published: December 2010

AbstractThe incidence of new infections is a key measure of the status of the HIV epidemic, but accurate measurement of incidence is often constrained by limited data. Karon et al. (Statist. Med. 2008; 27:4617–4633) developed a model to estimate the incidence of HIV infection from surveillance data with biologic testing for recent infection for newly diagnosed cases. This method has been implemented by public health departments across the United States and is behind the new national incidence estimates, which are about 40 per cent higher than previous estimates. We show that the delta method approximation given for the variance of the estimator is incomplete, leading to an inflated variance estimate. This contributes to the generation of overly conservative confidence intervals, potentially obscuring important differences between populations. We demonstrate via simulation that an innovative model‐based bootstrap method using the specified model for the infection and surveillance process improves confidence interval coverage and adjusts for the bias in the point estimate. Confidence interval coverage is about 94–97 per cent after correction, compared with 96–99 per cent before. The simulated bias in the estimate of incidence ranges from −6.3 to +14.6 per cent under the original model but is consistently under 1 per cent after correction by the model‐based bootstrap. In an application to data from King County, Washington in 2007 we observe correction of 7.2 per cent relative bias in the incidence estimate and a 66 per cent reduction in the width of the 95 per cent confidence interval using this method. We provide open‐source software to implement the method that can also be extended for alternate models. Copyright © 2010 John Wiley & Sons, Ltd.
Heavy‐Atomic Construction of Photosensitizer Nanoparticles for Enhanced Photodynamic Therapy of Cancer
Authors: Lim Chang‐Keun , Shin Jiyoung , Lee Yong‐Deok , Kim Jungahn , Park Hoyong , Kwon Ick Chan , Kim Sehoon 
Published: December 2010

AbstractA new type of heavy‐atom‐affected Pluronic (F‐127) nanoparticle (FIC NP) for photodynamic therapy (PDT) is reported. FIC NPs are formulated with biocompatible constituents, and contain densely integrated iodinated aromatic molecules that form a structurally rigid core matrix and stably encapsulate photosensitizers in a monomeric form. Tiny nanoparticles (≈10 nm) are prepared by aqueous dispersion of photosensitizer‐embedded aromatic nanodomains, which self‐assemble by phase separation from the Pluronic melt mixture. By using spectroscopic studies and cellular experiments, the following is demonstrated: 1) enhanced singlet‐oxygen generation by means of the intraparticle heavy‐atom effect on the embedded photosensitizer, 2) facilitated cell uptake due to the small nanoscopic size as well as the Pluronic surface characteristics, and thereby 3) actual enhancement of PDT efficacy for a human breast‐cancer cell line (MDA‐MB‐231), which validates a photophysically motivated nanoformulation approach toward an advanced photosensitizing nanomedicine.
Drug delivery: Logic‐Embedded Vectors for Intracellular Partitioning, Endosomal Escape, and Exocytosis of Nanoparticles (Small 23/2010)
Authors: Serda Rita E. , Mack Aaron , van de Ven Anne L. , Ferrati Silvia , Dunner Kenneth , Godin Biana , Chiappini Ciro , Landry Matthew , Brousseau Louis , Liu Xuewu , Bean Andrew J. , Ferrari Mauro 
Published: December 2010

AbstractA new generation of nanocarriers, logic‐embedded vectors (LEVs), is endowed with the ability to localize components at multiple intracellular sites, thus creating an opportunity for synergistic control of redundant or dual‐hit pathways. LEV encoding elements include size, shape, charge, and surface chemistry. In this study, LEVs consist of porous silicon nanocarriers, programmed for cellular uptake and trafficking along the endosomal pathway, and surface‐tailored iron oxide nanoparticles, programmed for endosomal sorting and partitioning of particles into unique cellular locations. In the presence of persistent endosomal localization of silicon nanocarriers, amine‐functionalized nanoparticles are sorted into multiple vesicular bodies that form novel membrane‐bound compartments compatible with cellular secretion, while chitosan‐coated nanoparticles escape from endosomes and enter the cytosol. Encapsulation within the porous silicon matrix protects these nanoparticle surface‐tailored properties, and enhances endosomal escape of chitosan‐coated nanoparticles. Thus, LEVs provide a mechanism for shielded transport of nanoparticles to the lesion, cellular manipulation at multiple levels, and a means for targeting both within and between cells.
Pasting and rheologic properties of potato starch and maize starch mixtures
Authors: Zhang Yayuan , Gu Zhengbiao , Hong Yan , Li Zhaofeng , Cheng Li 
Published: December 2010

AbstractThis study characterized the pasting and rheologic behavior of potato/maize starch mixtures of various ratios. Pasting analysis using a Brabender Viscograph indicated that most important pasting parameters did not show a linear change that reflected the ratio of starches. A significant effect on final viscosities and setback was evident. The diameter distribution of starch granules that were heated to 70°C was determined by a laser particle size analyzer. The result suggested that the swelling of starch granules in the mixtures was reduced at the onset of gelatinization. Measurement of dynamic viscoelasticity measurement demonstrated that the mixtures showed slightly higher loss modulus than those seen for the control at small measuring frequencies. The mixture pastes with a high proportion of potato starch exhibited more pseudoplasticity and had a more significant thickening effect than either control paste. Nonadditive behavior was found by mixing potato and maize starch. This suggests that an appropriate blend of starches from diverse botanical origins may provide a simple practical avenue for manipulation.
Reduction of solid content in starch industry wastewater by microfiltration
Authors: Šaranović Žana , Šereš Zita , Aleksandar Jokić , Pajin Biljana , Dokić Ljubica , Gyura Julianna , Dalmacija Božo , Simović Dragana Šoronja 
Published: December 2010

AbstractWastewater obtained in the production process of wheat starch and vital wheat gluten was treated by microfiltration through a ceramic tubular membrane with 200 nm pore sizes. The consumption of process water would thus be reduced, the starch would be recovered to a greater extent and the wastewater problem would consequently be solved. Reduction of the occurrence of polarization layer on the membrane and the constant wastewater permeate flux through the membrane was maintained by inserting of the mixer Kenics inside the membrane tube. The maximum value of the permeate flux (24 L m−2 h−1) without the use of a static mixer was achieved at 3 × 10−5 Pa and at a flow rate of 150 L/h, for wastewater samples initially allowed to settle for 4 h prior microfiltration. Under the very same conditions of the working parameters, the use of a static mixer enables a flux that is up to two or three times more intensive compared to the values obtained without using a mixer. Microfiltration reduces the wastewater dry matter from 11 000 to 4000 mg/L, lessens the chemical oxygen demand by 74%, i.e. from 21 000 to 5100 mgO2/L and significantly decreases the values of the suspended matter, namely from 9000 to 300 mg/L.
First word
Authors: Kirby Roger 
Published: December 2010

AbstractWe are all getting fatter. Obesity is reaching epidemic proportions throughout the developed and developing world. Obesity is a significant risk factor for premature death from cardiovascular disease. Data from the World Health Organization show that 17.1 million people around the world died of heart disease or stroke in 2004, and that number is predicted to rise to 23 million by 2030. Diabetes, which is another obesity‐related disease, is also rising alarmingly in prevalence. It is envisaged that the number of people worldwide suffering from diabetes will rise from the current 200 million to 366 million by 2030.How, then, can we help men to help themselves (one of the key aims of this new journal) to overcome the problem of obesity? We have found that five simple rules (rather than recommendations, which can easily be ignored) help men to get themselves into a better PLACE. Copyright © 2010 Wiley Interface Ltd
Liver disease in men
Authors: Williams Roger 
Published: December 2010

AbstractThe situation with respect to the three main liver diseases affecting adult men in the UK, namely alcoholic liver disease, chronic hepatitis B and C infection and the new epidemic of fatty liver disease, is truly horrendous and continuing to get worse. These conditions are to a large extent self‐induced, but if detected early, some reversal of the disease process is possible. Copyright © 2010 Wiley Interface Ltd
Henna as a Durable Preoperative Skin Marker
Authors: Mehendale Vinay G. , Chaudhari Namita C. , Shenoy Sharad N. , Mehendale Alap V. 
Published: December 2010

AbstractBackgroundFor many surgical procedures skin marking is required well before surgery and induction of anesthesia. In some cases, the patient may need to be standing or sitting while the skin area is marked. Marking of perforators and varicosities in chronic venous diseases, marking of stoma sites for urinary or fecal diversions are some examples. The side of surgery should ideally be marked preoperatively to avoid wrong side surgery. Marks made with conventional marking pens fade or disappear with preoperative skin preparation, whereas marks made with henna paste, which is orange to dark brown in color, last for up to 3 weeks in spite of regular showers and skin cleansing, even with ethanol. This property of henna encouraged us to use it as a preoperative skin marker.MethodsHenna paste was used as a preoperative skin marker in 250 patients. In 154 patients with chronic venous diseases, perforators and varicosities were marked during duplex scanning. Henna was used to mark the colostomy site in 28 patients with carcinoma of the rectum prior to abdominoperineal resection of the rectum (APR) (four of them laparoscopic APR) and the aspiration site in 11 patients with liver abscesses and 4 patients with pleural empyemas, under ultrasonographic (USG) guidance. In addition, henna was used to mark the correct side of surgery in 47 patients undergoing unilateral inguinal hernia surgery. Marking was done from 1 to 8 days before surgery.ResultsThe marking with henna was clearly visible in all the cases even after preoperative skin preparation with ethanol up to 8 days after application. There were no complications associated with the marking. All marks disappeared 4 weeks after application. In terms of successful execution of the desired procedure, the use of henna marking was successful in all the cases.ConclusionsHenna is an ideal substance for use as a preoperative skin marker. It can be safely and effectively used as a marker for varicose vein surgery, ultrasound‐guided identification of lesions, establishing the ideal site for stomas on the abdominal wall, and to identify the correct side of surgery. Markings made with henna are durable and do not fade with routine bathing or preoperative skin preparation. In most cases there are no associated complications. Henna is cheap, safe, and convenient, and indications for its use can be ubiquitous.
Correlation Between Tumor Budding and Post‐Resection Prognosis in Patients with Invasive Squamous Cell Carcinoma of the Thoracic Esophagus
Authors: Nakanishi Yoshitsugu , Ohara Masanori , Doumen Hiromitsu , Kimura Noriko , Ishidate Takuzo , Kondo Satoshi 
Published: December 2010

AbstractBackgroundTumor budding is defined as an isolated single cancer cell or a cluster of cancer cells composed of fewer than five cells at the invasive front of a tumor. The aim of the present study was to identify correlations between tumor budding and clinicopathological factors and their impact on postoperative prognosis in invasive squamous cell carcinoma of the thoracic esophagus.MethodsThe subjects were 82 patients who underwent curative resection. The number of tumors showing budding was counted immunohistochemically based on positivity for cytokeratin (AE1/AE3) to distinguish cancer cells from inflammatory cells, and the patients were divided into low‐grade and high‐grade budding groups. High‐grade budding was defined as ≥5 budding foci per field under a 20× objective lens.ResultsOne group of 36 patients (43.9%) and a second group of 46 patients (56.1%) were classified into the low‐grade and high‐grade budding groups, respectively. Patients in the high‐grade budding group had significantly larger tumor size, deeper depth of invasion, more frequent lymphatic invasion and venous invasion, as well as more lymph node metastases, than those in the low‐grade budding group. Disease‐free and overall survivals were worse in the high‐grade budding group than in the low‐grade budding group (P < 0.0001 and P = 0.0002, respectively). Three of four patients who had tumor recurrence more than 5 years postoperatively belonged to the low‐grade budding group.ConclusionsTumor budding appears to be an indicator of tumor growth and invasiveness. Patients with low‐grade budding are likely to have a better prognosis than those with high‐grade budding, but the tumor may recur in the late phase postoperatively in patients with low‐grade budding.
Cost‐Utility Estimation of Surgical Treatment of Pancreatic Carcinoma Aimed at Cure
Authors: Ljungman David , Lundholm Kent , Hyltander Anders 
Published: December 2010

AbstractBackgroundLittle is reported on costs for radical tumor resections of pancreatic carcinoma in relationship to adjusted quality of life survival postoperatively. Therefore, the aim of the present study was to estimate the cost utility of surgical treatment aimed at cure.MethodsA population‐based cohort of patients with exocrine or ampullary pancreatic adenocarcinoma resected for cure in Gothenburg University Hospitals during 1998–2005 were evaluated retrospectively (n = 139). Total inpatient and outpatient healthcare costs were available for 103 patients, and health‐related quality of life (HRQL) (based on the SF‐36 Health Survey) were assessed preoperatively and postoperataively in 119 patients. Survival and utility index (SF‐36‐6D) across 5 years of postoperative follow‐up were used to achieve quality adjusted life years.ResultsMean survival after resection was 977 days for patients with exocrine pancreatic carcinoma, with expected differences among subgroups as related to disease stage (p < 0.01), in agreement with international reports. The HRQL index was 0.65 ± 0.06 preoperatively, 0.63 ± 0.04 early postoperatively (<1 year) and 0.69 ± 0.06 at long‐term follow‐up (1–5 years) compared to 0.77 ± 0.02 in age‐matched healthy reference individuals from the Swedish population (p < 0.05). Total lifetime costs for treatments including surgery and adjuvant chemotherapy were €39,000 per patient, with a mean of 1.13 (95% Confidence Interval [CI] 0.93–1.40) QALYs across 5 years follow‐up. The cost per QALY was €35,000 (95% CI €28,026–€41,947).ConclusionsResection aimed at cure of pancreatic exocrine ductal carcinoma provided costs for one quality adjusted year of survival comparable to other complex surgical treatments within cost limits regarded as reasonable to bear by the Swedish health care system, as well as in several other Western countries.
Impact of nodal involvement on surgical outcomes of intrahepatic cholangiocarcinoma: a multicenter analysis by the Study Group for Hepatic Surgery of the Japanese Society of Hepato‐Biliary‐Pancreatic Surgery
Authors: Uchiyama Kazuhisa , Yamamoto Masakazu , Yamaue Hiroki , Ariizumi Shun‐ichi , Aoki Taku , Kokudo Norihiro , Ebata Tomoki , Nagino Masato , Ohtsuka Masayuki , Miyazaki Masaru , Tanaka Eiichi , Kondo Satoshi , Uenishi Takahiro , Kubo Shoji , Yoshida Hiroshi , Unno Michiaki , Imura Satoru , Shimada Mitsuo , Ueno Masaki , Takada Tadahiro 
Published: December 2010

AbstractBackground/purposeThe aim of this study was to clarify the prognostic factors of intrahepatic cholangiocarcinoma (ICC) following hepatectomy and to examine the impact of lymph node metastasis on survival. This study was therefore carried out as a Project Study of the Japanese Society of Hepato‐Biliary‐Pancreatic Surgery.MethodsThree hundred and forty‐one patients who underwent hepatectomy for ICC between 1995 and 2004 at the 9 institutions of the Medical University Hospitals were analyzed retrospectively. Multivariate regression analyses and a Kaplan–Meyer analysis were performed to identify prognostic factors.ResultsPathological lymph node metastasis was one of the significant factors affecting overall survival (hazard ratio 2.10,p < 0.001) based on the multivariate analysis. Among the patients who underwent extended lymphadenectomy beyond the hepatoduodenal ligament, the median survival of 121 patients with nodal involvement was 12.2 months. Only seven patients with nodal involvement have survived for more than 4 years.ConclusionsIn the present study, preoperative carbohydrate antigen (CA) 19‐9, intrahepatic metastasis, and nodal involvement were the significant independent predictors of poor prognosis by multivariate analysis. Further prospective studies may thus be needed to confirm these findings, because this study has a limitation in that it was a retrospective study with multicenter data collection.