bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regenerative Tourism and Mental Health: The Clean Wave Foundation, Costa Rica
Authors: Thornton Michele , Bhatia Marty , Silkaitis Carin 
Published: May 2024

AbstractRising mental health needs combined with barriers in access to care has individuals seeking new approaches to accessing care and improving their overall sense of well-being. Intentional forms of tourism, particularly nature-based, and regenerative tourism may have a role to play as an opportunity to address this growing need in a way that traditional efforts to address mental health may be lacking. While studies have begun to document the physical health, mental health and perceptions of well-being impacts of nature-based, sustainable or ecotourism they are just beginning to explore this with regards to regenerative tourism. Regenerative tourism, is slightly more nuanced, and is described as “leaving the place behind better than before.” A hallmark of a sound regenerative tourism model, is that it emerges from within the community, and is often tied to a local community organization doing the ongoing work that spearheads the practice. This paper employs grounded theory to proposes a new model linking regenerative tourism to well-being and documents a qualitative study conducted in the Spring of 2023 with a regenerative based organization (The Clean Wave Foundation)—that connects individuals with beach and underwater clean-up events across Costa Rica. Key participants (n = 12) discuss their experiences, personal well-being and community impacts in a semi-structured interview format. Community organizations, economic development agencies, the tourism industry and scholars in marketing and public health will all find benefit in this work.
Cruise Passengers’ Expenditures in Relation to Satisfaction Levels in a Mediterranean Port of Call
Authors: Polykalas Spyros , Sgora Aggeliki , Konidaris Agisilaos 
Published: May 2024

AbstractTourist satisfaction has been recognized as a key element for tourism growth and promotion in all sectors of the tourism industry. Although several studies have been published analysing the importance of cruise tourism to local and national economies, only few of them address the relation between cruise tourist satisfaction and tourism expenditures, especially in new ports of call. This paper examines such interrelations to passengers’ expenditure on goods and services during their stay in a port. The analysis is based on a survey on cruise passengers porting in Argostoli, which is the main port of Kefalonia island (Greece). Findings indicate that cruise passengers’ satisfaction is a key element to elevated levels of expenditure during staying on a visited port, since there is a strong correlation between tourists spending and level of tourist satisfaction. This empirical evidence provided from the analysis of the data present implications for policymakers in search of methods to stimulate economic growth and development on tourist destinations.
Centralization of Information to Understand the Consumer Within the Restaurant Sector
Authors: Maldonado Castillo Idalia , Martínez Ortiz Fabiola Yahel , Guzmán Flores Jessie Paulina 
Published: May 2024

AbstractThe proliferation of online restaurant reviews presents a challenge for consumers seeking valuable insights amid scattered and decentralized information. Despite the potential in these reviews, businesses often decline to explore such information due to perceived expense and unclear future impact. This study integrates technological tools within McKinsey’s consumer decision journey model to navigate this digital landscape effectively. Through analysis of influencer reviews on Twitter and Instagram, as well as objective evaluations on rating platforms like TripAdvisor and Yelp, the study aims to present the information in a centralized and objective way, closer to the reality of a user regarding the aspects of a restaurant in the attempt of helping the consumer decision-making. The paper also provides the restaurant sector relevant information about diner consumption habits, consumer behavior related to multiple factors or improvement areas according to what is reviewed, thus, suggesting a business improvement.
The Challenges of Sustainability Assessment Tools in (Tourism) Higher Education
Authors: Dimou Irini , Xenaki Maria 
Published: May 2024

AbstractSustainability and higher education are closely linked, with universities playing a crucial role in promoting sustainability. Furthermore, the significance of incorporating sustainability in (tourism) higher education is beyond doubt. However, incorporating sustainability poses challenges such as unclear definitions and resistance to change. To overcome this, proactive measures and attention to governance are necessary. Towards this direction, Higher Education Institutions can create sustainability reports to showcase progress and identify areas for improvement. Despite efforts to develop standards and methods for assessing sustainability practices, there is still a gap in identifying specific criteria for a truly sustainable university. This article discusses the challenges associated with sustainability integration in HEIs and concludes that the wide variety of available Sustainability Assessment Tools (SATs) could potentially complicate rather than foster the process of integration. The challenges emerging are being discussed, in order to advance the applicability and effectiveness of SATs.
Hydrostatics
Authors: Rapp Christoph 
Published: May 2024

AbstractPart II covers the book’s core: applied, one dimensional hydraulics which starts with hydrostatics in Chapter 7. At the beginning hydrostatic pressure, pressure force and buoyancy are described. Next, the very helpful pressure diagrams are introduced before the hydrostatic paradox is discussed. Subsequently, the pressure on arbitrarily inclined flat objects is considered in the framework of the resulting forces and moments of force. Moving liquids and the consideration of compressed air volumes at constant temperatures (Boyle-Mariotte law) complete the chapter.
Assessment of rarity and ecological preferences of the non-marine ostracods (Crustacea) in Çanakkale Province (Türkiye)
Authors: Yavuzatmaca Mehmet , Külköylüoğlu Okan , Ataman Alper , Ayteğin Ahmet , Yılmaz İsmail Ömer 
Published: May 2024

AbstractRarity as a multidimensional concept has not been discussed for the ostracods along with the effects of physicochemical factors and sedimentation rates of waters on their distribution. We randomly sampled 91 aquatic sites including eight habitat types in the Çanakkale Province to study ostracod species rarity, commonness, and ecological preferences, and to test the relationships between the rarity index (average of geographic range, habitat specificity, and population size indices) and environmental factors. A total of 44 ostracod taxa (25 living) were reported from 75 sites. Among the species, Candonocypris caledonica was recorded for the first time in Türkiye. Sixty percent of 25 living species exhibited cosmopolitan characteristics, making significant contributions to the diversity of ostracods. The well-known cosmopolitan species, Heterocypris salina (rr = 0.268), Cypridopsis vidua (rr = 0.289), Limnocythere inopinata (rr = 0.330), Ilyocypris bradyi (rr = 0.370), and Psychrodromus olivaceus (rr = 0.390), were identified as common species based on the rarity index (rr) values. Of the environmental variables, only sediment grain sizes (×2000, ×500, and ×63 μm) were found to be effective on the distribution of ostracod species. The Shannon index exhibited a positively significant association with ×2000, while the population size index displayed a linear relationship with ×63 μm grain size, indicating a small population size and rarity. Associations among index values, sediment grain size, and water quality variables showed that comprehensive studies on ostracods, analyzing both water and sediment, can provide a clearer and more precise information for evaluating the rarity and ecological preferences of species.
Lebensqualität nach innerklinischem Herz-Kreislauf-Stillstand
Authors: Treml Benedikt , Eckhardt Christine , Oberleitner Christoph , Ploner Thomas , Rugg Christopher , Radovanovic Spurnic Aleksandra , Rajsic Sasa 
Published: May 2024

Zusammenfassung
Hintergrund
Ein Herz-Kreislauf-Stillstand (HKS) ist ein lebensbedrohlicher Zustand, der weltweit eine der häufigsten Todesursachen darstellt. Die Literatur bezüglich der Lebensqualität nach kardiopulmonaler Reanimation ist limitiert und beinhaltet hauptsächlich Daten von HKS außerhalb des Krankenhauses. Diese könnten sich bezüglich Epidemiologie und Outcome von innerklinischen Herz-Kreislauf-Stillständen (IHCA) unterscheiden. Ziel dieser Studie war es, die Lebensqualität mittels EQ-5D-5L-Fragebogen nach einem IHCA zu untersuchen und mögliche Risikofaktoren für ein schlechteres Outcome zu ermitteln.

Material und Methoden
Diese retrospektive Datenanalyse und prospektive Erhebung der Lebensqualität umfasste alle Patient:innen, die einen IHCA im Zeitraum von 2010 bis 2020 überlebten. Der primäre Endpunkt der Studie war die Lebensqualität am Stichtag nach einem IHCA. Sekundäre Endpunkte umfassten Prädiktoren für ein schlechteres Outcome.

Ergebnisse
Insgesamt wurden innerhalb des Zeitraums von 11 Jahren 604 innerklinische Reanimationen durchgeführt, wobei 61 (10 %) der Patient:innen bis zum Zeitpunkt der Befragung überlebten. Achtundvierzig (79 %) Patient:innen erfüllten die Einschlusskriterien, und 31 (65 %) wurden in diese Studie eingeschlossen. Es gab keinen signifikanten Unterschied in der Lebensqualität vor und nach dem HKS (EQ-5D-5L Utilität 0,79 vs. 0,78; p = 0,567) und im EQ-5D-5L-VAS-Score. Eine chirurgische Indikation für die Krankenhausaufnahme war mit einer besseren Lebensqualität nach dem IHCA assoziiert, verglichen mit einer medizinischen Aufnahmeindikation (p = 0,009).

Schlussfolgerung
Patient:innen, die einen innerklinischen Herz-Kreislauf-Stillstand überlebten, zeigten eine vergleichbare Lebensqualität vor und nach dem Ereignis. Dennoch berichteten die Patient:innen über eine Verschlechterung der Mobilität und der Angst/Depression. Künftige Studien sollten bei der Erhebung der Folgen eines Herz-Kreislauf-Stillstands die verfügbaren Instrumente zur Bewertung der Lebensqualität miteinbeziehen.
A non-compact convex hull in generalized non-positive curvature
Authors: Basso Giuliano , Krifka Yannick , Soultanis Elefterios 
Published: May 2024

AbstractGromov’s (open) question whether the closed convex hull of finitely many points in a complete $${{\,\textrm{CAT}\,}}(0)$$

CAT

(
0
)

space is compact naturally extends to weaker notions of non-positive curvature in metric spaces. In this article, we consider metric spaces admitting a conical geodesic bicombing, and show that the question has a negative answer in this setting. Specifically, for each $$n>1$$

n
>
1

, we construct a complete metric space X admitting a conical geodesic bicombing, which is the closed convex hull of n points and is not compact. The space X moreover has the universal property that for any n points $$A=\{x_1,\ldots ,x_n\}\subset Y$$

A
=
{

x
1

,
…
,

x
n

}
⊂
Y

in a complete $${{\,\textrm{CAT}\,}}(0)$$

CAT

(
0
)

space Y there exists a Lipschitz map $$f:X\rightarrow Y$$

f
:
X
→
Y

such that the convex hull of $$A$$
A
is contained in f(X).
Rational engineering of Halomonas salifodinae to enhance hydroxyectoine production under lower-salt conditions
Authors: Yang Niping , Liu Mengshuang , Han Jing , Jiang Mingyue , Zeng Yan , Liu Ying , Xiang Hua , Zheng Yanning 
Published: May 2024

Abstract
Hydroxyectoine is an important compatible solute that holds potential for development into a high-value chemical with broad applications. However, the traditional high-salt fermentation for hydroxyectoine production presents challenges in treating the high-salt wastewater. Here, we report the rational engineering of Halomonas salifodinae to improve the bioproduction of hydroxyectoine under lower-salt conditions. The comparative transcriptomic analysis suggested that the increased expression of ectD gene encoding ectoine hydroxylase (EctD) and the decreased expressions of genes responsible for tricarboxylic acid (TCA) cycle contributed to the increased hydroxyectoine production in H. salifodinae IM328 grown under high-salt conditions. By blocking the degradation pathway of ectoine and hydroxyectoine, enhancing the expression of ectD, and increasing the supply of 2-oxoglutarate, the engineered H. salifodinae strain HS328-YNP15 (ΔdoeA::PUP119-ectD p-gdh) produced 8.3-fold higher hydroxyectoine production than the wild-type strain and finally achieved a hydroxyectoine titer of 4.9 g/L in fed-batch fermentation without any detailed process optimization. This study shows the potential to integrate hydroxyectoine production into open unsterile fermentation process that operates under low-salinity and high-alkalinity conditions, paving the way for next-generation industrial biotechnology.

Key points
• Hydroxyectoine production in H. salifodinae correlates with the salinity of medium
• Transcriptomic analysis reveals the limiting factors for hydroxyectoine production
• The engineered strain produced 8.3-fold more hydroxyectoine than the wild type

Graphical Abstract
Influence of stimulation frequency on brain-derived neurotrophic factor and cathepsin-B production in healthy young adults
Authors: Nishikawa Yuichi , Sakaguchi Hiroyuki , Takada Tatsuya , Maeda Noriaki , Hyngstrom Allison 
Published: May 2024

AbstractElectrical muscle stimulation (EMS) has been shown to stimulate the production of myokines (i.e., brain-derived neurotrophic factor (BDNF)), but the most effective EMS parameters for myokine production have not been fully elucidated. The purpose of this study was to quantify the optimal EMS frequency for stimulating myokine production. This study included sixteen young adults (male, n = 13, age = 27.3 ± 5.5 years). Participants underwent four EMS interventions (20 min each) with the following conditions: (1) 4 Hz, (2) 20 Hz, (3) 80 Hz, and (4) control (no intervention). Blood samples were obtained before and immediately after EMS. For the control condition, blood samples were taken before and after 20 min of quiet sitting. BDNF and cathepsin-B levels were analyzed in serum. Compared to preintervention levels, stimulation at 20 Hz resulted in significantly greater postintervention cathepsin-B and BDNF levels (p < 0.01). On the other hand, the control condition did not result in a significant change between pre- and posttreatment. Furthermore, stimulation at 20 Hz caused significantly larger increases in cathepsin-B and BDNF levels than stimulation at 4–80 Hz or the control condition (p < 0.05). In conclusion, stimulation at 20 Hz effectively causes a robust cathepsin-B and BDNF response. Based on these results, we suggest a new strategy for rehabilitation of people with neurological disorders.
Voriconazole metabolism is associated with the number of skin cancers per patient
Authors: Ike Jacqueline I. , Smith Isabelle T. , Mosley Dominique , Madden Christopher , Grossarth Sarah , Halle Briana R. , Lewis Adam , Mentch Frank , Hakonarson Hakon , Bastarache Lisa , Wheless Lee 
Published: May 2024

AbstractVoriconazole exposure is associated with skin cancer, but it is unknown how the full spectrum of its metabolizer phenotypes impacts this association. We conducted a retrospective cohort study to determine how variation in metabolism of voriconazole as measured by metabolizer status of CYP2C19 is associated with the total number of skin cancers a patient develops and the rate of development of the first skin cancer after treatment. There were 1,739 organ transplant recipients with data on CYP2C19 phenotype. Of these, 134 were exposed to voriconazole. There was a significant difference in the number of skin cancers after transplant based on exposure to voriconazole, metabolizer phenotype, and the interaction of these two (p < 0.01 for all three). This increase was driven primarily by number of squamous cell carcinomas among rapid metabolizes with voriconazole exposure (p < 0.01 for both). Patients exposed to voriconazole developed skin cancers more rapidly than those without exposure (Fine-Grey hazard ratio 1.78, 95% confidence interval 1.19–2.66). This association was similarly driven by development of SCC (Fine-Grey hazard ratio 1.83, 95% confidence interval 1.14–2.94). Differences in voriconazoles metabolism are associated with an increase in the number of skin cancers developed after transplant, particularly SCC.
Electroacupuncture and carbamazepine for patients with trigeminal neuralgia: a randomized, controlled, 2 × 2 factorial trial
Authors: Li Rongrong , Sun Jing , Luo Kaitao , Luo Ning , Sun Ruohan , Gao Feng , Wang Yiyi , Xia Yunfan , Li Xiaoyu , Chen Lifang , Ma Ruijie , Shao Xiaomei , Liang Yi , Fang Jianqiao 
Published: May 2024

Abstract
Background
Trigeminal neuralgia (TN) is difficult to treat due to its severe pain intensity and recurring episodes, which significantly impact quality of life.

Objectives
We aimed to assess the effectiveness of electroacupuncture (EA) in alleviating the pain intensity in TN, and to determine whether EA combined with low-dosage carbamazepine (CBZ) has a synergistic effect.

Methods
A multi-centre, randomized, 2 × 2 factorial trial was conducted. Participants who met the inclusion criteria received active EA or sham EA for 60 min, three times a week for four weeks; CBZ (300 mg per day) or placebo for four weeks. The primary outcome was the change in visual analog scale (VAS) score from baseline to weeks 2, 4, 16, and 28. Secondary outcomes included quality of life and adverse events.

Results
A total of 120 participants (75 females and 45 males; mean (SD) age, 58.5 (15.3) years) were included. The main effects of EA and CBZ were significant (P < 0.001), and there was a significant interaction was identified between the interventions (P = 0.041). Participants who received EA (mean difference [MD], −0.3 [95% CI, −0.40 to −0.20] at week 2; −1.6 [−1.70 to −1.50] at week 4; −1.1 [−1.31 to −0.89] at week 16; −0.8 [−1.01 to −0.59] at week 28), CBZ (MD, −0.6 [95% CI, −0.70 to −0.50] at week 2; −0.9 [−1.03 to −0.77] at week 4, −0.2 [−0.41 to 0.01] at week 16, 0.2 [−0.01 to 0.41] at week 28), and the combination of both (MD, −1.8 [95% CI, −1.90 to −1.70] at week 2; −3.7 [−3.83 to −3.57] at week 4, −3.4 [−3.61 to −3.19] at week 16, −2.9 [−3.11 to −2.69] at week 28) had a greater reduction in VAS score over the treatment phase than their respective control groups (sham EA, placebo, and sham EA plus placebo). EA-related adverse events (6/59, 10.17%) were lower than that of CBZ (15/59, 25.42%) during the whole phases.

Conclusions
EA or CBZ alone are effective treatments for TN, while the combination of EA and low-dosage CBZ exerts a greater benefit. These findings in this trial demonstrate that the combination of EA and low-dosage CBZ may be clinically effective under certain circumstances.

Trial registration
NCT03580317.
Age prediction using fundus parameters of normal eyes from the Kumejima population study
Authors: Yamashita Takehiro , Terasaki Hiroto , Asaoka Ryo , Iwase Aiko , Sakai Hiroshi , Sakamoto Taiji , Araie Makoto 
Published: May 2024

Abstract
Purpose
Artificial intelligence can predict the age of an individual using color fundus photographs (CFPs). This study aimed to investigate the accuracy of age prediction in the Kumejima study using fundus parameters and to clarify age-related changes in the fundus.

Methods
We used nonmydriatic CFPs obtained from the Kumejima population study, including 1,646 right eyes of healthy participants with reliable fundus parameter measurements. The tessellation fundus index was calculated as R/(R + G + B) using the mean value of the red–green–blue intensity in eight locations around the optic disc and foveal region. The optic disc ovality ratio, papillomacular angle, and retinal vessel angle were quantified as previously described. Least absolute shrinkage and selection operator regression with leave-one-out cross-validation was used to predict age. The relationship between the actual and predicted ages was investigated using Pearson’s correlation coefficient.

Results
The mean age of included participants (834 males and 812 females) was 53.4 ± 10.1 years. The mean predicted age based on fundus parameters was 53.4 ± 8.9 years, with a mean absolute error of 3.64 years, and the correlation coefficient between actual and predicted age was 0.88 (p < 0.001). Older patients had greater red and green intensities and weaker blue intensities in the peripapillary area (p < 0.001).

Conclusions
Age could be predicted using the CFP parameters, and there were notable age-related changes in the peripapillary color intensity. The age-related changes in the fundus may aid the understanding of the mechanism of fundus diseases such as age-related macular degeneration.
Maternal perinatal social support and infant social-emotional problems and competencies: a longitudinal cross-cohort replication study
Authors: Schuijers Melanie , Greenwood Christopher J. , McIntosh Jennifer E. , Youssef George , Letcher Primrose , Macdonald Jacqui A. , Spry Elizabeth , Le Bas Genevieve , Teague Samantha , Biden Ebony , Elliott Elizabeth , Allsop Steve , Burns Lucinda , Olsson Craig A. , Hutchinson Delyse M. 
Published: May 2024

Abstract
Purpose
Maternal perinatal social support is theorised to promote offspring social-emotional development, yet few studies have prospectively examined this relationship. Findings may inform preventative intervention efforts, to support a healthy start to emotional life.

Methods
This study examined whether maternal social support perinatally predicts infant social-emotional development at 12 months of age in two longitudinal cohort studies: The Australian Temperament Project (ATP) (n = 1,052 mother-infant dyads [653 mothers, Mage_at_birth = 32.03, 88% Australian-born; 1,052 infants, 52% girls]) and The Triple B Pregnancy Cohort Study (Triple B) (n = 1,537 dyads [1,498 mothers, Mage_at_birth = 32.53, 56% Australian-born; 1,537 infants, 49% girls]). Social support was assessed at pregnancy (third trimester) and eight-weeks post-birth. Infant social-emotional competencies (ATP: Brief Infant and Toddler Social and Emotional Assessment (BITSEA), Competencies Scale; Triple B: Bayley Scales of Infant and Toddler Development-Social Emotional Scale) and problems (ATP: BITSEA, Problems Scale; Triple B: Ages and Stages Questionnaires: Social-Emotional Scale), were assessed at 12-months of age.

Results
In ATP, social support was associated with lower offspring problems (pregnancy: β = -0.15; post-birth: β = -0.12) and greater competencies (pregnancy: β = 0.12; post-birth: β = 0.16) at 12 months. In Triple B, social support also predicted lower offspring problems (pregnancy: β = -0.11; post-birth: β = -0.07) and greater competencies (pregnancy: β = 0.07) at 12 months. Findings did not indicate an association between support at eight-weeks post-birth and subsequent competencies (β = 0.06).

Conclusions
Evidence suggests that perinatal social support promotes healthy infant social and emotional development. These results underscore the critical importance of social support for mothers transitioning into parenthood.