bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Enantioselective Catalysis
Authors: Lee Ai‐Lan 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: N‐Heterocyclic Carbene Containing Complexes in Catalysis
Authors: Bantreil Xavier , Broggi Julie , Nolan Steven P. 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Use of Osmium‐DNA Complexes
Authors: Okamoto Akimitsu 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemistry of 1‐Benzotelluropyrylium Salts: Synthesis, Structure and Reactions
Authors: Sashida Haruki , Minoura Mao 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Substituted Aromatic Compounds Using Ruthenium‐Catalyzed Ring‐Closing Metathesis
Authors: Yoshida Kazuhiro , Imamoto Tsuneo , Yanagisawa Akira 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Development of New Methodology for Bond Activation by Transition Metal Complexes and Their Application Toward Functional Molecule Synthesis
Authors: Nishihara Yasushi 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Total Synthesis of Otteliones Possessing Powerful Tubulin Polymerization Inhibitory Activity
Authors: Araki Hiroshi , Katoh Tadashi 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Spectrum of Histologic Changes in Colonic Biopsies in Patients Treated with Mycophenolate Mofetil
Authors: Selbst Megan K. , Ahrens William A. , Robert Marie E. , Friedman Amy , Proctor Deborah D. , Jain Dhanpat 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Animal Silks: Their Structures, Properties and Artificial Production
Authors: Fu Chengjie , Shao Zhengzhong , Fritz Vollrath 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Aromaticity and Tautomerism in Porphyrins and Porphyrinoids
Authors: Stepien M. , Latos‐Grazynski L. 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Spectroelectrochemistry: The Best of Two Worlds
Authors: Kaim Wolfgang , Fiedler Jan 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Route of intracerebrospinal fluid chemotherapy administration and efficacy of therapy in neoplastic meningitis
Authors: Glantz Michael J. , Van Horn Alixis , Fisher Rebecca , Chamberlain Marc C. 
Published: February 2010

AbstractBACKGROUND:A study was undertaken to determine whether route (intraventricular vs intralumbar) of intracerebrospinal fluid (intra‐CSF) drug administration influences progression‐free survival in the treatment of patients with neoplastic meningitis, which occurs in 1% to 5% of patients with known cancer. Currently available treatment options result in modest responses, which is in part a reflection of obstacles to drug delivery into the leptomeningeal space.METHODS:One hundred patients with clinically and cytologically or radiographically documented neoplastic meningitis because of solid cancers received intra‐CSF liposomal cytarabine or methotrexate as specified in a randomized phase 4 trial. The 2 treatment arms were well balanced for demographic and tumor‐related characteristics of known prognostic importance, including age, performance status, tumor type, extent of systemic and other central nervous system (CNS) disease, prior CNS therapy, and concurrent systemic chemotherapy.RESULTS:One hundred patients were randomized and treated (52 with sustained‐release cytarabine, and 48 with methotrexate). Progression‐free survival (the primary study endpoint) was identical between the sustained‐release cytarabine and methotrexate treatment arms for all 100 patients (35 vs 37.5 days, P = .79). When progression‐free survival was examined as a function of route of chemotherapy administration (lumbar vs ventricular), there was no difference for patients treated with sustained‐release cytarabine (29 vs 43 days, P = .35). For patients treated with methotrexate, however, there was a statistically significant difference favoring patients receiving intraventricular therapy (19 vs 43 days, P = .048).CONCLUSIONS:Site of intra‐CSF chemotherapy drug administration is clinically relevant with short half‐life drugs such as methotrexate. Cancer 2010. © 2010 American Cancer Society.
Analysis of prognostic factors in Ewing sarcoma using a population‐based cancer registry
Authors: Lee Joe , Hoang Bang H. , Ziogas Argyrios , Zell Jason A. 
Published: February 2010

AbstractBACKGROUND:Ewing sarcoma is a high‐grade malignancy that most often occurs in children. Because its occurrence in adults has been historically low, few studies have been published on the epidemiology of Ewing sarcoma in this group of patients. By using data from a large, population‐based cancer registry, the authors designed the present study to examine the outcome of children and adult patients with Ewing sarcoma and relevant prognostic factors.METHODS:A retrospective analysis of Ewing sarcoma patient cases in the California Cancer Registry database was performed to identify incident patient cases diagnosed between 1989‐2007. Comparisons were made to examine differences in demographics, disease characteristics, treatment, and survival. Survival analyses were performed using Kaplan‐Meier method with log‐rank tests and Cox proportional hazards models.RESULTS:Seven hundred and twenty‐five incident patient cases of Ewing sarcoma were identified, including 372 (51.3%) children and 353 (48.7%) adults. Hispanic race was associated with young age (P = .001) and lower socioeconomic status (SES; P = .0001). Pelvic involvement was associated with large tumor size (>8 cm; P < .0001), an increased incidence of metastasis (P < .0002), and poorer survival (P < .0001). After adjusting for clinically relevant factors, statistically significant decreased overall survival was seen with adults (hazard ratio [HR], 1.71; 95% confidence interval [CI], 1.35‐2.17), Hispanics (HR, 1.33; 95% CI, 1.01‐1.75), metastatic disease (HR, 2.74; 95% CI, 2.14‐3.49), large tumor size (HR, 1.65; 95% CI, 1.17‐2.34), no surgical treatment, and low SES.CONCLUSIONS:The authors determined that adult age, Hispanic race, metastatic disease, large tumor size, and low SES are poor prognostic factors for overall survival among Ewing sarcoma patient cases. Cancer 2010. © 2010 American Cancer Society.
Nuclear grading of primary pulmonary adenocarcinomas
Authors: Nakazato Yoshimasa , Minami Yuko , Kobayashi Hiromi , Satomi Kaishi , Anami Yoichi , Tsuta Koji , Tanaka Ryota , Okada Masafumi , Goya Tomoyuki , Noguchi Masayuki 
Published: February 2010

AbstractBACKGROUND:According to the World Health Organization Classification of Tumors, the prognostic value of morphometric cytologic atypia has not been assessed in pulmonary adenocarcinoma.METHODS:Primary tumors of 133 pulmonary adenocarcinomas ≤2 cm were analyzed using an image processor for analytical pathology. The results were evaluated using receiver operator characteristic curve analysis, and survival curves were drawn by the Kaplan‐Meier method. Furthermore, the results were applied to routine histological diagnosis. Four pathologists evaluated the nuclear factors relative to the size of small lymphocytes as a standard.RESULTS:By using the nuclear area and nuclear major axis dimension, lung adenocarcinomas were divisible into 2 groups showing extremely favorable prognosis and fairly favorable prognosis, without considering histological features or classification. A nuclear area level of <67 μm2 was correlated with longer survival (P < .0001), and the 5‐year survival rate was 90.4%. Similarly, a nuclear diameter level of <0.7 μm was correlated with longer survival (P = .0002), and the 5‐year survival rate was 88.6%. The mean (±standard deviation [SD]) value of the kappa statistic for the 4 pathologists who evaluated the cases using the size of small lymphocytes as a standard was 0.58 ± 0.10, and the mean (±SD) value of the accuracy metric was 0.66 ± 0.10.CONCLUSIONS:Nuclear area and nuclear major dimension are 2 useful independent markers for evaluating the prognosis of lung adenocarcinoma. Cancer 2010. © 2010 American Cancer Society.
Increasing cytotechnologist workload above 100 slides per day using the ThinPrep imaging system leads to significant reductions in screening accuracy
Authors: Elsheikh Tarik M. , Kirkpatrick Joseph L. , Cooper Mackenzie K. , Johnson Mary L. , Hawkins Allison P. , Renshaw Andrew A. 
Published: February 2010

AbstractBACKGROUND:With the current and projected shortage of a cytotechnologist (CT) workforce and the desire to reduce laboratory costs, increased productivity with automated assisted primary screening has become an attractive option for many laboratories. To the best of the authors' knowledge, longitudinal studies examining the effect of increasing workload on the performance of individual CTs have not been performed previously.METHODS:Using the ThinPrep imaging system (TIS), the performance of 3 CTs with variable levels of experience were evaluated. Their productivity was noted to increase from an average of 87 to 118 slides per day. The analysis included comparisons of error rates, screening rates, and screening times, including a review of 22 fields of view (FOV). Poststudy interviews of the CTs were also performed.RESULTS:Increased workload was found to be proportional to the decreased percentage of cases that underwent full manual review (25.2% to 20.1%; P < .001), and decreased actual screening times (7.3 hours/day to 6.7 hours/day, and 5.0 minutes/slideto 3.7 minutes/slide). This resulted in a lower detection of total abnormal findings (10.4% to 8.3%; P < .001), atypical squamous cells (6.7% to 4.9%; P < .001), and high‒grade squamous intraepithelial lesion (0.9 %to 0.7%; P = .37), as well as an increased false‐negative fraction rate (3.8% to 7.0%; P = .08).CONCLUSIONS:The results of the current study indicate that an increased average CT workload >100 slides per day with the TIS appears to have been accomplished mostly through a reduction in the amount of time spent reviewing the 22 FOV and the percentage of cases that underwent full manual review, which resulted in a significantly reduced screening performance. Cancer (Cancer Cytopathol) 2010. © 2010 American Cancer Society.
Development of nitrergic neurons in the nervous system of the locust embryo
Authors: Stern Michael , Böger Nicole , Eickhoff René , Lorbeer Christina , Kerssen Ulrike , Ziegler Maren , Martinelli Giorgio P. , Holstein Gay R. , Bicker Gerd 
Published: February 2010

AbstractWe followed the development of the nitric oxide‐cyclic guanosine monophosphate (NO‐cGMP) system during locust embryogenesis in whole mount nervous systems and brain sections by using various cytochemical techniques. We visualized NO‐sensitive neurons by cGMP immunofluorescence after incubation with an NO donor in the presence of the soluble guanylyl cyclase (sGC) activator YC‐1 and the phosphodiesterase‐inhibitor isobutyl‐methyl‐xanthine (IBMX). Central nervous system (CNS) cells respond to NO as early as 38% embryogenesis. By using the NADPH‐diaphorase technique, we identified somata and neurites of possible NO‐synthesizing cells in the CNS. The first NADPH‐diaphorase‐positive cell bodies appear around 40% embryogenesis in the brain and at 47% in the ventral nerve cord. The number of positive cells reaches the full complement of adult cells at 80%. In the brain, some structures, e.g., the mushroom bodies acquire NADPH‐diaphorase staining only postembryonically. Immunolocalization of L‐citrulline confirmed the presence of NOS in NADPH‐diaphorase‐stained neurons and, in addition, indicated enzymatic activity in vivo. In whole mount ventral nerve cords, citrulline immunolabeling was present in varying subsets of NADPH‐diaphorase‐positive cells, but staining was very variable and often weak. However, in a regeneration paradigm in which one of the two connectives between ganglia had been crushed, strong, reliable staining was observed as early as 60% embryogenesis. Thus, citrulline immunolabeling appears to reflect specific activity of NOS. However, in younger embryos, NOS may not always be constitutively active or may be so at a very low level, below the citrulline antibody detection threshold. For the CNS, histochemical markers for NOS do not provide conclusive evidence for a developmental role of this enzyme. J. Comp. Neurol. 518:1157–1175, 2010. © 2010 Wiley‐Liss, Inc.
Role of sperm αvβ3 integrin in mouse fertilization
Authors: Boissonnas Céline Chalas , Montjean Debbie , Lesaffre Corinne , Auer Jana , Vaiman Daniel , Wolf Jean‐Philippe , Ziyyat Ahmed 
Published: February 2010

AbstractOocyte integrins have been described as essential for fertilization. But this concept has been challenged by deletion experiments. Recently, we have shown that sperm integrin α6β1 plays a determinant role in mouse gamete interaction. In this study, we demonstrate the presence of αvβ3 integrin by Western blot and immunofluorescence on the sperm membrane. Oocytes and/or sperm preincubations with anti‐αv or anti‐β3 antibodies were performed before in vitro fertilization on cumulus‐intact and zona‐free egg assays. We observed inhibitory effects on the fusion process mostly by means of sperm function. An antibody directed against vitronectin inhibited gametes fusion, whereas the presence of exogenous vitronectin increased its efficiency. We suggest that vitronectin (on multimeric forms) can play a first nonspecific link corresponding to loosely bound spermatozoa to oocyte and that this link could be mediated by means of oocyte proteoglycans or integrins, and sperm αvβ3 integrin. Developmental Dynamics 239:773–783, 2010. © 2010 Wiley‐Liss, Inc.
Fusion of uniluminal vascular spheroids: A model for assembly of blood vessels
Authors: Fleming Paul A. , Argraves W. Scott , Gentile Carmine , Neagu Adrian , Forgacs Gabor , Drake Christopher J. 
Published: February 2010

AbstractBlood vessel formation via vascular fusion. When placed into hanging drop culture, five uniluminal vascular spheroids fuse to form a single, larger diameter spheroid with an outer layer of smooth muscle alpha actin positive cells (red) and an inner PECAM‐1 positive endothelium (green) surrounding a large central lumen. From Fleming et al., Developmental Dynamics 239:398–406, 2010.
Synthesis, Characterization, and Protonation Reactions of Ar‐BIAN and Ar‐BICAT Diimine Platinum Diphenyl Complexes
Authors: Parmene Jerome , Krivokapic Alexander , Tilset Mats 
Published: February 2010

AbstractPtII diphenyl complexes (N–N)PtPh2 [N–N = diimines Ar–N=C(An)C=N–Ar with Ar = substituted aryl groups] have been prepared and characterized by 1H, 13C, and 195Pt NMR spectroscopy. The 195Pt NMR spectroscopic data establish the electronic influence exerted by substituents at the backbone of the diimine ligand system to the metal center. When compared to diimines Ar–N=CMe–CMe=N–Ar, the electron‐withdrawing ability of the Ar‐BIAN ligand and the electron‐donating ability of the O,O‐heterocyclic Ar‐BICAT systems are demonstrated. Trends in 195Pt NMR chemical shifts suggest that electronic tuning of the metal center is better achieved through variations of the diimine backbone substituents rather than variation of the substituents at the N‐Aryl groups. Protonation of (N–N)PtPh2 in dichloromethane/acetonitrile at –78 °C furnishes the corresponding PtIV hydrides (N–N)PtPh2H(NCMe)+. The PtIV hydrides liberate benzene with the formation of (N–N)PtPh(NCMe)+ when the temperature is raised. A second protonation and rapid benzene elimination produces the dicationic PtII species (N–N)Pt(NCMe)22+ at approximately 50 °C. Protonation of (N–N)PtPh2 in the absence of acetonitrile results in the clean formation of (N–N)PtPh(η2‐C6H6)+ at temperatures that depend on the steric hindrance provided by the alkyl substituents at the diimine N‐aryl groups. These findings support the notion that the metal is the kinetically preferred site of protonation. The results qualitatively agree with a recent mechanistic study of protonation‐induced reactions of (diimine)PtPh2 complexes that bear simple methyl substituents at the diimine backbone. Several compounds have been crystallographically characterized. All complexes have the expected square planar environment at the metal. Modest variations in the metric parameters suggest that the Ar‐BICAT system has a weaker trans influence than the Ar‐BIAN and Ar‐DAB systems.
Acridone‐Benzimidazole Ring‐Fused Ligands: A New Class of Sensitizers of Lanthanide Luminescence via Low‐Energy Excitation
Authors: Deiters Emmanuel , Gumy Frédéric , Bünzli Jean‐Claude G. 
Published: February 2010

AbstractTwo monotopic tridentate ligands, namely HLAB1 and HLAB2 have been synthesized which feature an acridone chromophore fused on a benzimidazolepyridine framework. They differ from each other by their connection points between a N‐methylacridone and a N‐methylbenzimidazole chromophoric moieties. Both ligands self‐assemble with LnIII ions in neat acetonitrile to form thermodynamically stable neutral complexes of general formula [Ln(LABX)3] (log β13 in the range 22–25). Subsequent photophysical investigations conducted in the same solvent demonstrate that ligand HLAB1 sensitizes europium luminescence (QLEu = 10 % and τEu = 0.93 ms) whereas ligand HLAB2 sensitizes the luminescence of NIR‐emitting LnIII ions, in particular YbIII (QLYb = 0.86 % and τYb = 29.3 μs). The sensitization efficiencies ηsens of both ligands have been determined for these two complexes and found to be around 50–60 %. The main advantage of these ligands is their excitation wavelength which lies in the visible range (410–430 nm).
Recent Developments in the Synthesis of Pyrrolidine‐Containing Iminosugars
Authors: Stocker Bridget L. , Dangerfield Emma M. , Win‐Mason Anna L. , Haslett Gregory W. , Timmer Mattie S. M. 
Published: February 2010

AbstractAs noted inhibitors of glycosidases, iminosugars have enormous therapeutic potential in the treatment of a number of diseases such as cancer, diabetes, and lysosomal storage disorders. Accordingly, much effort has been expended over the past decades in developing novel and efficient methodologies for the synthesis of iminosugars. This microreview highlights recent (post 2005) developments in the synthesis of pyrrolidine‐containing iminosugars and includes discussions of methodologies such as ring‐closing metathesis, aldol and pericyclic reactions, and protecting‐group free strategies.
Gold(I)‐Catalyzed Tandem Rearrangement–Nucleophilic Substitution of α‐Acetoxy Alkynyl Oxiranes or Aziridines: Efficient Approach to Furans and Pyrroles
Authors: Blanc Aurélien , Alix Aurélien , Weibel Jean‐Marc , Pale Patrick 
Published: February 2010

AbstractHighly substituted furans and pyrroles were efficiently formed by a new gold(I)‐catalyzed tandem rearrangement–nucleophilic substitution of acetoxylated alkynyl oxiranes and aziridines in the presence of various nucleophiles.
Differential characterization of biogenic amine‐producing bacteria involved in food poisoning using MALDI‐TOF mass fingerprinting
Authors: Fernández‐No Inmaculada C. , Böhme Karola , Gallardo José M. , Barros‐Velázquez Jorge , Cañas Benito , Calo‐Mata Pilar 
Published: February 2010

AbstractHistamine poisoning is caused by the consumption of fish and other foods that harbor bacteria possessing histidine decarboxylase activity. With the aim of preventing histamine formation, highly specific mass spectral fingerprints were obtained from the 16 major biogenic amine‐producing enteric and marine bacteria by means of MALDI‐TOF MS analysis. All bacterial strains analyzed exhibited specific spectral fingerprints that enabled its unambiguous differentiation. This technique also identified peaks common to certain bacterial groups. Thus, two protein peaks at m/z 4182±1 and 8363±6 were found to be present in all Enterobacteriaceae species analyzed except for Morganella morganii. Peaks at m/z 3635±1 and 7267±2 were specific to both M. morganii and Proteus spp. Biogenic amine‐forming Proteus spp. exhibited three genus‐specific peaks at m/z 3980, 7960±1 and 9584±2. The genus Photobacterium also showed three genus‐specific peaks at m/z 2980±1, 4275±1 and 6578±1. The two histamine‐producing Gram‐positive bacteria Lactobacillus sp. 30A and Staphylococcus xylosus exhibited a few protein peaks in the 2000–7000 m/z range and could be easily distinguished from biogenic amine‐forming Gram‐negative bacteria. Clustering based on MALDI‐TOF MS also exhibited a good correlation with phylogenetic analysis based on the 16S rRNA gene sequence, validating the ability of the MALDI‐TOF technique to establish relationships between microbial strains and species. The approach described in this study leads the way toward the rapid and specific identification of major biogenic amine‐forming bacteria based on molecular protein markers with a goal to the timely prevention of histamine food poisoning.