bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: SmI2‐Mediated Coupling of Nitrones and tert‐Butanesulfinyl Imines with Allenoates: Synthesis of β‐Methylenyl‐γ‐lactams and Tetramic Acids.
Authors: Xu Chu‐Pei , Huang Pei‐Qiang , Py Sandrine 
Published: July 2012

AbstractThe reaction of various nitrones with allenoates proceeds with formation of β‐methylenyl‐γ‐amino esters, which can be further transformed to γ‐lactams of type (IV) as substructures of natural products.
ChemInform Abstract: A Fluorene‐Modified Porphyrin for Efficient Dye‐Sensitized Solar Cells.
Authors: Wu Cheng Hua , Pan Tsung‐Yu , Hong Shang‐Hao , Wang Chin‐Li , Kuo Hshin‐Hui , Chu Yang‐Yun , Diau Eric Wei‐Guang , Lin Ching‐Yao 
Published: July 2012

AbstractPorphyrins bearing a polyaromatic or a heterocyclic group are prepared to study their fundamental and photovoltaic properties.
ChemInform Abstract: Silver‐Promoted Friedel—Crafts Reaction: Concise Total Synthesis of (‐)‐Ardeemin, (‐)‐Acetylardeemin and (‐)‐Formylardeemin.
Authors: Wang Y. , Kong C. , Du Y. , Song H. , Zhang D. , Qin Y. 
Published: July 2012

AbstractDirect alkylation of bromopyrroloindoline (I) with prenyl tributylstannane gives derivative (III) as key intermediate in the total synthesis of multidrug resistant inhibitor (‐)‐formylardeemin (IV).
ChemInform Abstract: Design and Synthesis of 4‐Alkynyl Pyrazoles as Inhibitors of PDE4: A Practical Access via Pd/C—Cu Catalysis.
Authors: Gorja Dhilli Rao , Kumar K. Shiva , Kandale Ajit , Meda Chandana Lakshmi T. , Parsa Kishore V. L. , Mukkanti K. , Pal Manojit 
Published: July 2012

AbstractA facile Pd—C/CuI/PPh3 mediated C—C bond forming reaction between pyrazole iodide and several terminal alkynes leads to title compounds (III).
ChemInform Abstract: Benzylic Arylation of 2‐Methyl‐5‐membered Heterocycles Using TMP‐Bases.
Authors: Duez Stephanie , Steib Andreas K. , Knochel Paul 
Published: July 2012

AbstractA new effective method for direct benzylic arylation of various heterocyclic compounds with aromatic and heteroaromatic bromides is developed.
ChemInform Abstract: 1,3‐Di‐n‐butylimidazolium Tribromide‐Mediated Chemoselective Oxidative Cyclization of Benzothiazoyl Carbaimides: A Novel Approach Toward the Synthesis of N‐Bis‐benzothiazole Derivatives.
Authors: Kumbhare Ravindra M. , Dadmal Tulshiram , Kosurkar Umesh , Kumar K. Vijay 
Published: July 2012

AbstractBenzothiazolyl carbaimides (III) and (VI) are obtained from aminobenzothiazoles (I) and (V) and isothiocyanates (II) by a novel method using DMAP as a catalyst.
ChemInform Abstract: Facile One‐Pot Three‐Component Reaction to Synthesize Trifluoromethylated Cyclopenta[b]pyran Derivatives and Their Further Transformation.
Authors: Liu Jianning , Li Jia , Zhang Li , Song Liping , Zhang Min , Cao Weiguo , Zhu Shizheng , Deng Hongmei , Shao Min 
Published: July 2012

AbstractThe method offers a convenient and exclusive access to the anellated pyran structures (IV).
ChemInform Abstract: A Single Step Approach to Piperidines via Ni‐Catalyzed β‐Carbon Elimination.
Authors: Kumar Puneet , Louie Janis 
Published: July 2012

AbstractThe [4 + 2]‐cycloaddition of N‐Boc azetidinone and alkynes afford 3‐piperidinones in high yields where a variety of internal alkynes is applied tolerating aliphatic, aromatic, trimethylsilyl and tributylstannyl groups.
ChemInform Abstract: Diastereoselective Synthesis of Tetrahydroquinolines via a Palladium‐Catalyzed Heck—Suzuki Cascade Reaction.
Authors: Wilson Jonathan E. 
Published: July 2012

AbstractBromoaniline substrates of type (I) and (IV) undergo Pd‐catalyzed Heck reaction followed by Suzuki coupling to provide trans‐tetrahydroquinoline scaffolds bearing a tertiary and a quaternary stereocenter with complete diastereoselectivity.
ChemInform Abstract: Synthesis of Benzoindoloquinolizines via a Cu(I)‐Mediated C—N Bond Formation.
Authors: Worayuthakarn Rattana , Nealmongkol Prattya , Ruchirawat Somsak , Thasana Nopporn 
Published: July 2012

AbstractThe reaction of the trans‐compound (IVe) to the compound (Ve) gives a lower yield.
ChemInform Abstract: Enviro‐Economic, Ultrasound‐Assisted One‐Pot, Three‐Component Synthesis of Pyrido[2,3‐d]pyrimidines in Aqueous Medium.
Authors: Hussein Essam M. 
Published: July 2012

AbstractThree‐component reaction of aminouracils (I) with aromatic aldehydes (II) and malonic acid derivatives (III) proceeds smoothly in water using tetrabutylammonium bromide as phase transfer catalyst under sonication.
ChemInform Abstract: Direct Synthesis of B‐Allyl and B‐Allenyldiisopinocampheylborane Reagents Using Allyl or Propargyl Halides and Indium Metal under Barbier‐Type Conditions.
Authors: Hirayama Lacie C. , Haddad Terra D. , Oliver Allen G. , Singaram Bakthan 
Published: July 2012

AbstractThe intermediate borane reagents react with carbonyl compounds to afford homoallylic and homopropargylic alcohols with low to excellent enantioselectivity.
ChemInform Abstract: Copper(II)‐Catalyzed Silyl Conjugate Addition to α,β‐Unsaturated Conjugated Compounds: Broensted Base‐Assisted Activation of Si—B Bond in Water.
Authors: Calderone Joseph A. , Santos Webster L. 
Published: July 2012

AbstractThe reaction is applied to a variety of α,β‐unsaturated carbonyl compounds like esters, aldehydes or linear and cyclic ketones.
ChemInform Abstract: Synthesis of 1‐Amino‐2‐vinylcyclopropane‐1‐phosphinates. Conversion of a Phosphonate to Phosphinates.
Authors: Pyun Hyung‐Jung , Clarke Michael O. , Cho Aesop , Casarez Anthony , Ji Mingzhe , Fardis Maria , Pastor Richard , Sheng X. Christopher , Kim Choung U. 
Published: July 2012

AbstractThe conversions proceed via mono ester (II) by either nucleophilic or electrophilic alkylation to produce a broad spectrum of amino acid biosteres.
ChemInform Abstract: Synthesis of Novel Benzosuberone Derivatives Using Organophosphorus Reagents and Their Antitumor Activities.
Authors: Boulos Leila S. , Abdel‐Malek Hoda A. , El‐Sayed Naglaa F. 
Published: July 2012

AbstractCompounds (IV) and (VI) possess promising inhibiting activity in cell proliferation of MCF 7 and HEPG2 cells.
ChemInform Abstract: Copper‐Catalyzed Aerobic Oxidative Trifluoromethylation of H‐Phosphonates Using Trimethyl(trifluoromethyl)silane.
Authors: Chu Lingling , Qing Feng‐Ling 
Published: July 2012

AbstractThe method seems to be generally efficient for the formation of biologically important components bearing a ‐CF3 function.
ChemInform Abstract: Thioester‐isocyanides: Versatile Reagents for the Synthesis of Cycle—Tail Peptides.
Authors: Rotstein Benjamin H. , Winternheimer David J. , Yin Lois M. , Deber Charles M. , Yudin Andrei K. 
Published: July 2012

AbstractThe preparation of a novel class of thioester isocyanides (II) and their utility in the synthesis of peptide macrocycles, e.g. (V), is reported.
ChemInform Abstract: N‐Amination of Amino Acids and Its Derivatives Using N‐Boc‐O‐Tosyl Hydroxylamine as an Efficient NH‐Boc Transfer Reagent: Electrophilic Amination.
Authors: Baburaj Thankappan , Thambidurai Sivalingam 
Published: July 2012

AbstractAmino acids, esters, and alcohols react with agent (II) to produce Boc‐protected hydrazino derivatives in good yields.
ChemInform Abstract: A Novel Sugar‐Based Intramolecular Ugi 3CC for the N‐Alkyl‐3‐oxo‐4‐aryl‐octahydrofuro[2,3‐f][1,4]oxazepine‐5‐carboxamides.
Authors: Reddy B. V. Subba , Majumder Nilanjan , Rao T. Prabhakar , Sridhar B. 
Published: July 2012

AbstractFor the first time, a bifunctional carbohydrate‐derived aldehyde/acid is employed for the reaction with amines and isocyanides to provide a novel class of derivatives (IV), suitable for library synthesis.
ChemInform Abstract: A Concise Synthesis of a Highly Strained Cyclobutane in Solanoeclepin A by Radical Cyclization.
Authors: Komada Takema , Adachi Masaatsu , Nishikawa Toshio 
Published: July 2012

AbstractThe key step is a samarium‐mediated 4‐exo‐trig radical cyclization to give the cyclobutanone (VIII) which possesses the highly strained tricyclodecane skeleton found in the title compound.
A comprehensive discussion of HMBC pulse sequences. 2. Some useful variants
Authors: Furrer Julien 
Published: July 2012

AbstractThe classical HMBC experiment, introduced in the first part, has revolutionized NMR spectroscopy for the structural studies of small to medium molecules, and impressive examples for structure elucidation of organic molecules, peptides, or natural products making use of the HMBC experiment have been published in the last 20 years. In the first article, we have explored the mechanisms of the two (2D)‐HMBC pulse sequence and have discussed how the pulse sequence elements cooperate to the observed cross‐peaks, wanted and unwanted. We have seen that further improvement of the 2D‐HMBC pulse sequence can be achieved by properly setting the acquisition and processing parameters. After a short introduction, this second article, with the aid of product operator formalism, will provide a comprehensive description of some useful HMBC pulse sequences. Building from basic principles, the constant‐time HMBC variant, the sensitivity‐enhanced HMBC, and some strategy for rejecting unwanted 1
JCH signals are explained in detail. © 2012 Wiley Periodicals, Inc. Concepts Magn Reson Part A 40A: 146–169, 2012.
A facile approach for synthesis of BiVO4 nano‐particles possessing high surface area and various morphologies
Authors: Golmojdeh H. , Zanjanchi M. A. 
Published: July 2012

AbstractBiVO4 with dominant monoclinic structure and relatively high surface area has been prepared by a simple precipitation method. Smaller particle size and new morphologies were observed while using non‐toxic and common organic additives including ethylene diamine tetra acetic acid (EDTA) as the synthesis constituents. The prepared materials were characterized using structural, textural and microscopic techniques. The photocatalytic activities of the samples were checked using methylene blue, phenol and 2,4,6‐trichlorophenol as probe molecules and visible light as irradiation source. Also, hydrothermally‐ synthesized counterparts of the catalysts were prepared and their structure and photocatalytic efficiency were compared. The recovery of the catalysts after successive uses was also examined.
Model order reduction of nonlinear circuit equations
Authors: Steinbrecher Andreas , Stykel Tatjana 
Published: July 2012

SUMMARYIn this paper, we present a model order reduction approach for nonlinear circuit equations with a small number of nonlinear elements. This approach is based on the decoupling of linear and nonlinear subcircuits and reducing the linear part using balancing‐related model reduction techniques. The efficiency and applicability of the proposed model reduction approach is demonstrated on numerical examples. Copyright © 2012 John Wiley & Sons, Ltd.
Cytomorphologic features of metastatic urothelial carcinoma in serous effusions
Authors: Cheng Huang Cheng , Attele Anoja , Michael Claire W. 
Published: July 2012

AbstractMetastatic urothelial carcinoma (UC) to serous effusion (SE) is extremely rare and its cytomorphological features have only been described in case reports. In this study, we searched the pathology database at University of Michigan for SEs due to metastatic UC in the last 20 years. A total of 25 cases from 20 patients with clinically and pathologically confirmed metastatic UC in SEs were retrieved. The specimens consisted of 15 pleural, 8 peritoneal, and 2 pericardial effusions. Smears were reviewed and evaluated for the following features: cellularity, single cells, cell clusters or short cords, cell wrapping, “windows” between the cells, two‐tone cytoplasm, cytoplasmic vacuoles, signet ring cells, nuclear to cytoplasmic (N/C) ratio, nuclear hyperchromasia, irregular nuclear membrane, nuclear centricity, double or multiple nuclei, nucleoli, anaplastic cells and mitosis. Our results showed that UC manifested in SEs predominantly as a single cell population with or without clusters or short cords, and frequently exhibited the “cell wrapping” of two or more cells. Individual UC cell in SEs exhibited nuclear enlargement with increased N/C ratio, irregular nuclear membranes, hyperchromatic coarse chromatin and frequently prominent nucleoli. Double or multinucleated cells, cells with vacuolated cytoplasm or signet ring appearance were also frequently present. Our results demonstrated that while certain features could suggest the diagnosis of UC, the cytomorphological features are not specific and often overlap with those of reactive mesothelium, mesothelioma, metastatic adenocarcinoma, or squamous cell carcinoma in SEs. Accurate diagnosis of UC rests on the combination of clinical history, cytomorphologic features and appropriate immunohistochemical panel. Diagn. Cytopathol. 2013. © 2012 Wiley Periodicals, Inc.
CINtec® PLUS dual immunostain: A triage tool for cervical pap smears with atypical squamous cells of undetermined significance and low grade squamous intraepithelial lesion
Authors: Loghavi Sanam , Walts Ann E. , Bose Shikha 
Published: July 2012

AbstractASC and LSIL comprise the majority of abnormal Pap smears. Currently, high‐risk human papillomavirus testing is utilized to triage women with ASC for colposcopy; however, no cost effective triage method is available for LSIL. p16 and Ki‐67 have each been shown to be good biomarkers for high grade cervical intraepithelial neoplasia (HG CIN).We evaluated the role of the CINtec® PLUS p16/Ki‐67 dual immunostain as a marker for underlying (U) or subsequent (S) HG CIN. One hundred and eighty eight cervical SurePath Pap smears with histological and/or cytological follow‐up were retrieved from our departmental files. The Pap stained slides were destained and then immunostained utilizing the CINtec® PLUS dual staining reagent kit. Results of the dual stain were correlated with follow‐up diagnoses. Sensitivity, specificity, and positive and negative predictive values of CINtec® PLUS for U or S HG CIN were compared with those of HR HPV testing and with p16 and Ki‐67 immunostaining alone. The sensitivity of CINtec® PLUS for U or S HG CIN was 91% in the ASC group and 100% in the LSIL group, while the corresponding specificities were 61 and 43%, respectively. The sensitivity and specificity of CINtec® PLUS for U or S HG CIN in both groups combined were 97 and 53%, respectively. CINtec® PLUS was more specific than HR HPV testing and Ki‐67 and p16 immunostains alone in detecting an U or S HG CIN. CINtec® PLUS is a helpful adjunct in identifying U or S HG CIN when applied to SurePath Pap smears with ASC or LSIL. Diagn. Cytopathol. 2013. © 2012 Wiley Periodicals, Inc.
Increased diagnostic yield of endoscopic ultrasound‐guided fine needle aspirates with flow cytometry and immunohistochemistry
Authors: Sodikoff Jamie B. , Johnson Hunter L. , Lewis Melinda M. , Garud Sagar S. , Bharmal Sheila J. , Keilin Steven A. , Siddiqui Momin T. , Cai Qiang , Willingham Field F. 
Published: July 2012

Endoscopic ultrasound‐guided fine needle aspiration (EUS‐FNA) is the most sensitive and specific test for establishing a tissue diagnosis for many gastrointestinal malignancies; however, cytologic morphology alone may not be definitive for subsets of tumors. Our aim was to quantify the impact of the broad application of flow cytometry (FC) and immunohistochemistry (IHC) on EUS‐FNA diagnostic yield.A retrospective chart review was performed on EUS procedures at a tertiary referral, academic medical center. All EUS‐FNA cases performed over a 21‐month period were examined.Of 606 EUS procedures reviewed during the period of study, 264 utilized FNA. After pancreatic cyst cases were excluded, 235 EUS‐FNA cases for 221 patients were selected for analysis. For cases with subsequent histological evaluation, including the subset utilizing FC/IHC, the sensitivity of EUS‐FNA was 89%, specificity was 100%, and accuracy was 91%. One quarter (58/235, 25%) of the tissue specimens underwent further testing by FC/IHC. There were 48 definitive diagnoses made in the subset utilizing FC/IHC. In 20 of the 48 diagnoses (42%), FC/IHC was deemed critical to the diagnosis, and without FC/IHC testing in those cases, the overall sensitivity and accuracy of EUS‐FNA would be reduced to 74 and 77%, respectively. FC/IHC allowed for six diagnoses rarely or not previously described by EUS‐FNA.Application of FC/IHC improves characterization predominantly for nonadenocarcinoma tumor subtypes and may lead to a diagnostic result for tumors not previously characterized by EUS‐FNA. With an adequate tissue sample, broad application of FC/IHC increases the diagnostic yield of EUS‐FNA. Diagn. Cytopathol. 2013;41:1043–1051. © 2012 Wiley Periodicals, Inc.
Perturbation study of climate change impacts in a snow‐fed river basin
Authors: Manandhar Sujata , Pandey Vishnu Prasad , Ishidaira Hiroshi , Kazama Futaba 
Published: July 2012

AbstractA physically based distributed hydrological model developed at the University of Yamanashi based on block‐wise use of TOPMODEL and the Muskingum–Cunge method (YHyM/BTOPMC), integrated with a simple degree‐day–based snow accumulation/melt sub‐model, was applied to evaluate hydrological responses under changing climatic conditions in the snow‐fed Kali Gandaki River Basin (KGRB) in Western Nepal. Rainy season precipitation (June to September) in the basin takes up about 80% of the annual precipitation, and dry season runoff is largely contributed by snowmelt. Climate change is likely to increase the probability of extreme events and problems related to water availability. Therefore, the study aimed to simulate runoff pattern under changing climatic conditions, which will be helpful in the management of water resources in the basin. Public domain global data were widely used in this study. The model was calibrated and validated with an acceptable degree of accuracy. The results predicted that the annual average discharge will increase by 2.4%, 3.7%, and 5.7% when temperature increases by 1, 2, and 3 °C compared with the reference scenario. Similarly, maximum, minimum, and seasonal discharges in the monsoon and pre‐monsoon seasons will also increase with rising temperature. Snowmelt runoff is found sensitive to temperature changes in the KGRB. Increasing temperature will cause a faster snowmelt, but precipitation will increase the snowpack and also shed a positive effect on the total annual and monsoonal discharge. For the combined scenarios of increasing temperature and precipitation, the annual average discharge will increase. In contrast, discharge during the increasing temperature and decreasing precipitation will tend to decrease. Copyright © 2012 John Wiley & Sons, Ltd.
Cytochemistry of fat body trophocytes and ovaries of workers and queens of Melipona quadrifasciata anthidioides (Hymenoptera: Apidae: Meliponini) during vitellogenesis
Authors: Paes‐de‐Oliveira Vagner Tadeu , Roat Thaisa Cristina , Berger Bruno , Da Cruz‐Landim Carminda 
Published: July 2012

AbstractABSTRACT The fat body (FB) of insects is where yolk proteins are synthesized. Therefore, relationships between the FB and oogenesis were studied in nurse workers, virgins, and physogastric queens of Melipona quadrifasciata anthidioides, a stingless bee in which the workers produce and lay eggs while provisioning brood cells. The relationships between FB and oogenesis, as well as the routes of materials from hemolymph to the oocytes, were studied through the cytochemical detection of lipids by osmium imidazole (OI), carbohydrates by ruthenium red (RR) and basic proteins by ammoniacal silver (AS). The results show differences in the presence of the studied materials in FB trophocytes and ovary of the classes of females studied and oogenesis phases. Material that tested positive for the treatments was detected among the classes of individuals studied in both, trophocytes and oocytes, and in the route of those materials from hemolymph to the oocytes. The differences found among the individual classes indicate relationships with the nutrition and adaptation to the parsimonious use of nutrients in the metabolism of reproduction. Microsc. Res. Tech., 2012. © 2012 Wiley Periodicals, Inc.
Effects of nitrogen deposition on soil organic carbon fractions in the subtropical forest ecosystems of S China
Authors: Chen Xiaomei , Li Yuelin , Mo Jiangming , Otieno Dennis , Tenhunen John , Yan Junhua , Liu Juxiu , Zhang Deqiang 
Published: July 2012

AbstractExperiments were conducted between 2003 and 2008 to examine how N additions influence soil organic C (SOC) and its fractions in forests at different succession stages in the subtropical China. The succession stages included pine forest, pine and broadleaf mixed forest, and old‐growth monsoon evergreen broadleaf forest. Three levels of N (NH4NO3)‐addition treatments comprising control, low‐N (50 kg N ha–1 y–1), and medium‐N (100 kg N ha–1 y–1) were established. An additional treatment of high‐N (150 kg N ha–1 y–1) was established in the broadleaf mixed forest. Soil samples were obtained in July 2008 for analysis. Total organic C (TOC), particulate organic C (POC, > 53 μm), readily oxidizable organic C (ROC), nonreadily oxidizable organic C (NROC), microbial biomass C (MBC), and soil properties were analyzed. Nitrogen addition affected the TOC and its fractions significantly. Labile organic‐C fractions (POC and ROC) in the topsoil (0–10 cm) increased in all the three forests in response to the N‐addition treatments. NROC within the topsoil was higher in the medium‐N and high‐N treatments than in the controls. In the topsoil profiles of the broadleaf forest, N addition decreased MBC and increased TOC, while no significant effect on MBC and TOC occurred in the pine and mixed forests. Overall, elevated N deposition increased the availability of labile organic C (POC and ROC) and the accumulation of NROC within the topsoil irrespective of the forest succession stage, and might enhance the C‐storage capacity of the forest soils.
Cigarette smoke disrupts the integrity of airway adherens junctions through the aberrant interaction of p120‐catenin with the cytoplasmic tail of MUC1
Authors: Zhang Lili , Gallup Marianne , Zlock Lorna , Basbaum Carol , Finkbeiner Walter E. , McNamara Nancy A. 
Published: July 2012

AbstractAdherens junctions (AJs) containing epithelial cadherin (E‐cad) bound to p120‐catenin (p120ctn) and β‐catenin (β‐ctn) play a crucial role in regulating cell–cell adhesion. Cigarette smoke abrogates cell–cell adhesion between epithelial cells by disrupting E‐cad, a hallmark of epithelial–mesenchymal transition (EMT), yet the underlying mechanism remains unknown. We used an organotypic culture of primary human bronchial epithelial (HBE) cells treated with smoke‐concentrated medium (Smk) to establish an essential role for the interaction between p120ctn and the cytoplasmic tail of MUC1 (MUC1‐CT) in regulating E‐cad disruption. Within the first 4 h of smoke exposure, apical MUC1‐CT repositioned to the basolateral membrane of pseudo‐stratified HBE cells, where it interacted with p120ctn. A time‐dependent increase in MUC1‐CT/p120ctn complexes occurred in conjunction with a time‐dependent dissociation of p120ctn/E‐cad/β‐ctn complexes, as well as the coordinated degradation of p120ctn and E‐cad. Interestingly, Smk induced a similar interaction between MUC1‐CT and β‐ctn, but this occurred 44 h after MUC1‐CT's initial interaction with p120ctn, and well after the AJs were destroyed. Blocking MUC1‐CT's interaction with p120ctn using a MUC1‐CT dominant‐negative peptide, PMIP, successfully abolished Smk's disruptive effects on AJs and recovered apical‐basolateral polarity of HBE cells. The MUC1‐CT/p120ctn interaction was highly dependent on EGFR/Src/Jnk‐mediated tyrosine phosphorylation (TyrP) of MUC1‐CT. Accordingly, EGFR, Src or Jnk inhibitors (AG1478, PP2, SP600125, respectively) abrogated Smk‐induced MUC1‐CT‐TyrP, MUC1‐CT/p120ctn interaction, AJ disruption, and loss of cellular polarity. Our work identified MUC1‐CT and p120ctn as important regulators of epithelial polarity and cell‐cell adhesion during a smoke‐induced EMT‐like process. Novel therapeutics designed to inhibit MUC1‐CT/p120ctn complex formation may prevent EMT in the smoker's airway. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.