bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the Credibility of the “YouTube Approach” to Health Information on Acute Myocardial Infarction
Authors: Pant Sadip , Deshmukh Abhishek , Murugiah Karthik , Kumar Gagan , Sachdeva Rajesh , Mehta Jawahar L 
Published: April 2012

AbstractBackground:This study was designed to assess the credibility of YouTube video information on acute myocardial infarction by exploring the relationship between accuracy of information on the topic, source of expertise, and perceived credibility of the message.Hypothesis:Health information videos in YouTube possess a diverse mix of information and can easily mislead online information seekers.Methods:The Web site http://www.YouTube.com was queried for the following search terms: “acute myocardial infarction,” “heart attack,” “acute coronary syndrome,” and “ST‐elevation myocardial infarction.” The resulting videos were categorized according to the source of the video and content was analyzed for discussion of different aspects of disease, ranging from pathophysiology to treatment.Results:Only 6% of videos touched upon all aspects of acute myocardial infarction. These were mostly from professional societies, were of long duration, and were among the least viewed. Videos that described personal experiences were “liked” or “disliked” most and had the majority of comments. Only 17% of the videos discussed the preventive aspects of the disease and stressed weight‐loss and exercise programs. Videos that stressed prevention were advertisements for specific weight‐loss programs (45%) and diet pills (30%). Very few videos stressed other risk factors. A large number of videos were irrelevant.Conclusions:YouTube is a popular platform across the globe for sharing video information, including videos related to health and disease. However, the information on this platform is not regulated and can easily mislead those seeking it. We suggest that authoritative videos should come from reputable sources such as professional societies and/or academic institutions and should provide unbiased and accurate information on all aspects of diseases like acute myocardial infarction. Clin. Cardiol. 2011 DOI: 10.1002/clc.21981The authors have no funding, financial relationships, or conflicts of interest to disclose.
Prospective surveillance and management of cardiac toxicity and health in breast cancer survivors
Authors: Schmitz Kathryn H. , Prosnitz Robert G. , Schwartz Anna L. , Carver Joseph R. 
Published: April 2012

AbstractBreast cancer is commonly diagnosed in postmenopausal women, the majority of whom express 1 or more cardiovascular disease risk factors. Cardiovascular disease poses a significant competing risk for morbidity and mortality among nonmetastatic breast cancer survivors. Adjuvant systemic therapies may result in late‐cardiac toxicity decades after treatment completion. The cumulative incidence of treatment‐related cardiotoxic outcomes may be as high as 33% after some adjuvant breast cancer therapies. Breast cancer treatment–induced cardiotoxicity may manifest as cardiomyopathy, coronary ischemia, thromboembolism, arrhythmias and conduction abnormalities, and valvular and pericardial disease. Evidence indicates that preexisting cardiovascular conditions such as hypertension or left ventricular dysfunction may compound the adverse effects of cardiotoxic treatments. There are currently no published clinical practice guidelines that address ongoing cardiac surveillance for cardiotoxicity after breast cancer, and existing guidelines for monitoring and promoting cardiovascular health in older women are often not followed. The multidisciplinary prospective surveillance system proposed elsewhere in this supplement would allow for earlier detection of cardiotoxicity from treatment and may improve monitoring of cardiovascular health in the growing population of breast cancer survivors. Cancer 2012;118(8 suppl):. © 2012 American Cancer Society.
A prospective surveillance model for physical rehabilitation of women with breast cancer
Authors: Stubblefield Michael D. , McNeely Margaret L. , Alfano Catherine M. , Mayer Deborah K. 
Published: April 2012

AbstractChemotherapy‐induced peripheral neuropathy (CIPN) results from damage to or dysfunction of the peripheral nerves. The development of CIPN is anticipated for the majority of breast cancer patients who receive neurotoxic chemotherapy, depending on the agent used, dose, and schedule. Sensory symptoms often predominate and include numbness, tingling, and distal extremity pain. Weakness, gait impairment, loss of functional abilities, and other deficits may develop with more severe CIPN. This article outlines a prospective surveillance model for physical rehabilitation of women with breast cancer who develop CIPN. Rehabilitative efforts for CIPN start at the time of breast cancer diagnosis and treatment planning. The prechemotherapy evaluation identifies patients with preexisting peripheral nervous system disorders that may place them at higher risk for the development of CIPN. This clinical evaluation should include a history focusing on symptoms and functional activities as well as a physical examination that objectively assesses the patient's strength, sensation, reflexes, and gait. Ongoing surveillance following the initiation of a neurotoxic agent is important to monitor for the development and progression of symptoms associated with CIPN, and to ensure its resolution over the long term. CIPN is managed best by a multidisciplinary team approach. Early identification of symptoms will ensure appropriate referral and timely symptom management. The prospective surveillance model promotes a patient‐centered approach to care, from pretreatment through survivorship and palliative care. In this way, the model offers promise in addressing and minimizing both the acute and long‐term morbidity associated with CIPN. Cancer 2012;. © 2012 American Cancer Society.
A prospective model of care for breast cancer rehabilitation: Postoperative and postreconstructive issues
Authors: McNeely Margaret L. , Binkley Jill M. , Pusic Andrea L. , Campbell Kristin L. , Gabram Sheryl , Soballe Peter W. 
Published: April 2012

AbstractAppropriate and timely rehabilitation is vital in the recovery from breast cancer surgeries, including breast conserving surgery, mastectomy, axillary lymph node dissection (ALND), and breast reconstruction. This article describes the incidence, prevalence, risk factors and time course for early postoperative effects and the role of prospective surveillance as a rehabilitation strategy to prevent and mitigate them. The most common early postoperative effects include wound issues such as cellulitis, flap necrosis, abscess, dehiscence, hematoma, and seroma. Appropriate treatment is necessary to avoid delay in wound healing that may increase the risk of long‐term morbidity, unduly postpone systemic and radiation therapy, and delay rehabilitation. The presence of upper quarter dysfunction (UQD), defined as restricted upper quarter mobility, pain, lymphedema, and impaired sensation and strength, has been reported in over half of survivors after treatment for breast cancer. Moreover, evidence suggests that survivors who undergo breast reconstruction may be at higher risk of UQD. Ensuring the survivor's optimum functioning in the early postoperative time period is critical in the overall recovery from breast cancer. The formal collection of objective measures along with patient‐reported outcome measures is recommended for the early detection of postoperative morbidity. Prospective surveillance, including preoperative assessment and structured surveillance, allows for early identification and timely rehabilitation. Early evidence supports a prospective approach to address and minimize postoperative effects. Cancer 2012;118(8 suppl):. © 2012 American Cancer Society.
Brilliant violet fluorophores: A new class of ultrabright fluorescent compounds for immunofluorescence experiments
Authors: Chattopadhyay Pratip K. , Gaylord Brent , Palmer Adrian , Jiang Nan , Raven Mary A. , Lewis Geoff , Reuter Morgan A. , Nur‐ur Rahman A.K.M. , Price David A. , Betts Michael R. , Roederer Mario 
Published: April 2012

AbstractThe Nobel Prize in Chemistry was awarded in 2000 for the discovery of conductive organic polymers, which have subsequently been adapted for applications in ultrasensitive biological detection. Here, we report the first use of this new class of fluorescent probes in a diverse range of cytometric and imaging applications. We demonstrate that these “Brilliant Violet” reporters are dramatically brighter than other UV‐violet excitable dyes, and are of similar utility to phycoerythrin (PE) and allophycocyanin (APC). They are thus ideally suited for cytometric assays requiring high sensitivity, such as MHC‐multimer staining or detection of intracellular antigens. Furthermore, these reporters are sensitive and spectrally distinct options for fluorescence imaging, two‐photon microscopy and imaging cytometry. These ultra‐bright materials provide the first new high‐sensitivity fluorescence probes in over 25 years and will have a dramatic impact on the design and implementation of multicolor panels for high‐sensitivity immunofluorescence assays. Published 2012 Wiley Periodicals, Inc.
Integrating Refined Kano Model, Quality Function Deployment, and Grey Relational Analysis to Improve Service Quality of Nursing Homes
Authors: Yeh Tsu‐Ming , Chen Shun‐Hsing 
Published: April 2012

AbstractBecause of the aging trend in Taiwan, long‐term care plays an important role in the medical system. Finding ways to ensure medical and service quality in long‐term care facilities requires immediate attention. This study discusses service quality in nursing homes and the factors that affect service quality in Taiwan in a way that benefits the management of these organizations. Using a refined Kano model analysis, 12 high value‐added qualities, 4 low value‐added qualities, 1 critical quality, 6 required qualities, 1 potential quality, and 2 care‐free qualities were found. Furthermore, using a combination of quality function deployment and Grey relational analysis (GRA), it was found that medical service standards of the nursing homes require improvement. Items such as “educational training,'' “professional capability,” “degree of understanding patients,” “communication skills,” and “crisis management ability” were provided by an equal‐weight GRA. The improvement sequence was “educational training,” “professional capability,” “communication skills,” “understanding of patients,” and “crisis management ability” in an equal‐weight quantified GRA. The research results can provide nursing homes with an improvement sequence for service design and operational management. © 2012 Wiley Periodicals, Inc.
Pathophysiology, impact, and management of hyponatremia
Authors: Edmonds Zachary V. 
Published: April 2012

AbstractHyponatremia's effects can be insidious, particularly in patients with heart failure, cirrhosis, and pneumonia. Appreciating its prevalence in hospitalized patients, recognizing its symptoms, characterizing its etiology, and employing appropriate management promptly will help reduce morbidity and mortality among hyponatremic patients. Journal of Hospital Medicine 2012; 7:S1–S5. © 2012 Society of Hospital Medicine
Quantification of changes in detrusor function and pressure‐flow parameters after radical prostatectomy: Relation to postoperative continence status and the impact of intensity of pelvic floor muscle exercises
Authors: Dubbelman Yvette , Groen Jan , Wildhagen Mark , Rikken Berend , Bosch Ruud 
Published: April 2012

AbstractObjectivesWe aim to quantify changes in detrusor function and pressure‐flow parameters after radical retropubic prostatectomy (RRP) and to determine the impact of the level of intensity of pelvic floor muscle exercises (PFME) on these changes. We also tried to identify preoperative urodynamic factors, predictive of postoperative continence status.MethodsSixty‐six patients were included in the study. An urodynamic examination was performed before surgery and 26 weeks after catheter removal. All patients were instructed in PFME. However the intensity of PFME varied between instructions based on an information folder only (F‐PFME) and intensive guidance by a physiotherapist, in addition to the folder (PG‐PFME).ResultsIn 66 men pre‐ as well as postoperative urodynamic studies were available for analysis. Overall, Qmax increased, pdet.Qmax and the urethral resistance factor URA decreased significantly after surgery. At baseline, detrusor overactivity (DOA) was found in 34% and 5.3% of the men who were still incontinent 6 months postoperatively and those who regained continence, respectively (P = 0.015). Postoperatively, Qmax was significantly higher (P = 0.04) and URA significantly lower (P = 0.047) in the physiotherapist‐guided group. No prognostic standard urodynamic factors for post‐RP incontinence (PRPI) were identified.ConclusionIn univariate analysis, preoperative DOA is associated with a higher risk of remaining incontinent after surgery. However, in multivariate analysis, urodynamic parameters predictive of PRPI could not be identified. Therefore, standard preoperative filling cystometry and pressure‐flow studies seem to have no role as preoperative predictors of PRPI in patients with localized prostate cancer. More intensive PFME might have a lowering effect on bladder outflow resistance after RRP. Neurourol. Urodynam. 31:637–641, 2012. © 2012 Wiley Periodicals, Inc.
Can preoperative urodynamic investigation be omitted in women with stress urinary incontinence? A non‐inferiority randomized controlled trial
Authors: van Leijsen S.A.L. , Kluivers K.B. , Mol B.W.J. , Broekhuis S.R. , Milani A.L. , Bongers M.Y. , Aalders C.I.M. , Dietz V. , Malmberg G.G. A. , Vierhout M.E. , Heesakkers J.P.F.A. 
Published: April 2012

AbstractAimsTo assess in women with stress urinary incontinence (SUI) the value of urodynamics prior to treatment.MethodsWe performed a multicenter non‐inferiority randomized controlled trial. Women with SUI were randomly allocated to management based on a workup with or without urodynamics. The primary outcome was clinical reduction of complaints as measured with the Urogenital Distress Inventory urinary incontinence subscale (UDI‐UI) at 12 months after the onset of treatment. A mean difference in improvement of less than 8 was considered non‐inferior. The study was analyzed according to intention‐to‐treat.ResultsThe trial was stopped prematurely because of slow recruitment. We randomly allocated 59 women to a strategy with (N = 31) or without (N = 28) urodynamics. The mean difference in improvement on the UDI‐UI was 14 in favor of the group without urodynamics (48 SD ± 22 vs. 34 SD ± 22, 95% CI: −28 to −0.26), confirming non‐inferiority. Addition of urodynamics did not result in a lower occurrence of de novo overactive bladder complaints compared to a workup without urodynamics (6/31 vs. 1/28; RR 5.4, 95% CI: 0.70–42). In the group allocated to urodynamics, initial surgical management was more often abandoned compared to the group not allocated to urodynamics (5/31 vs. 1/28; RR 4.5, 95% CI: 0.56–36).ConclusionsIn this relatively small study, the omission of urodynamics was not inferior to the use of urodynamics in the preoperative workup of women with SUI. Women with SUI undergoing urodynamics had the risk of a choice for more prudent treatment, which seemed to result in a delay until effective treatment. Neurourol. Urodynam. 31:1118–1123, 2012. © 2012 Wiley Periodicals, Inc.
Homology modeling and molecular dynamics simulations of the active state of the nociceptin receptor reveal new insights intoagonist binding and activation
Authors: Daga Pankaj R. , Zaveri Nurulain T. 
Published: April 2012

AbstractThe opioid receptor‐like receptor, also known as the nociceptin receptor (NOP), is a class A G protein‐coupled receptor (GPCR) in the opioid receptor family. Although NOP shares a significant homology with the other opioid receptors, it does not bind known opioid ligands and has been shown to have a distinct mechanism of activation compared to the closely related opioid receptors mu, delta, and kappa. Previously reported homology models of the NOP receptor, based on the inactive‐state GPCR crystal structures, give limited information on the activation and selectivity features of this fourth member of the opioid receptor family. We report here the first active‐state homology model of the NOP receptor based on the opsin GPCR crystal structure. An inactive‐state homology model of NOP was also built using a multiple template approach. Molecular dynamics simulation of the active‐state NOP model and comparison to the inactive‐state model suggest that NOP activation involves movements of transmembrane (TM)3 and TM6 and several activation microswitches, consistent with GPCR activation. Docking of the selective nonpeptidic NOP agonist ligand Ro 64‐6198 into the active‐state model reveals active‐site residues in NOP that play a role in the high selectivity of this ligand for NOP over the other opioid receptors. Docking the shortest active fragment of endogenous agonist nociceptin/orphaninFQ (residues 1–13) shows that the NOP extracellular loop 2 (EL2) loop interacts with the positively charged residues (8–13) of N/OFQ. Both agonists show extensive polar interactions with residues at the extracellular end of the TM domain and EL2 loop, suggesting agonist‐induced reorganization of polar networks, during receptor activation. Proteins 2012; © 2012 Wiley Periodicals, Inc.
Multiobjective process planning and scheduling using improved vector evaluated genetic algorithm with archive
Authors: Zhang Wenqiang , Fujimura Shigeru 
Published: April 2012

AbstractMultiobjective process planning and scheduling (PPS) is a most important practical but very intractable combinatorial optimization problem in manufacturing systems. Many researchers have used multiobjective evolutionary algorithms (moEAs) to solve such problems; however, these approaches could not achieve satisfactory results in both efficacy (quality, i.e., convergence and distribution) and efficiency (speed). As classical moEAs, nondominated sorting genetic algorithm II (NSGA‐II) and SPEA2 can get good efficacy but need much CPU time. Vector evaluated genetic algorithm (VEGA) also cannot be applied owing to its poor efficacy. This paper proposes an improved VEGA with archive (iVEGA‐A) to deal with multiobjective PPS problems, with consideration being given to the minimization of both makespan and machine workload variation. The proposed method tactfully combines the mechanism of VEGA with a preference for the edge region of the Pareto front and the characteristics of generalized Pareto‐based scale‐independent fitness function (gp‐siff) with the tendency to converge toward the central area of the Pareto front. These two mechanisms not only preserve the convergence rate but also guarantee better distribution performance. Moreover, some problem‐dependent crossover, mutation, and local search methods are used to improve the performance of the algorithm. Complete numerical comparisons show that the iVEGA‐A is obviously better than VEGA in efficacy, and the convergence performance is also better than NSGA‐II and SPEA2, while the distribution performance is comparable to and the efficiency is obviously better than theirs. © 2012 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
Biplots: the joy of singular value decomposition
Authors: Greenacre Michael J. 
Published: April 2012

AbstractThe biplot is a generalization of a scatterplot for two variables to the case of many variables. Instead of having samples represented as points with respect to two perpendicular axes, as in a bivariate scatterplot, there are as many axes as variables pointing in different directions. Samples are then perpendicularly projected onto axes to obtain approximate values of the data. The word ‘approximate’ is important, because it is not possible to represent data on many variables exactly by this procedure, but the biplot arranges the axes to display the data as accurately as possible, usually by least‐squares fitting. The ‘bi’ in biplot refers to the rows and columns of a multivariate data matrix, where the rows are usually cases and the columns are variables. Biplots are almost always displayed in a two‐dimensional plot but can just as well be displayed in three‐dimensions, with more accurate data representation, using suitable graphical software, for example dynamic rotation or conditioned plots. The usual linear biplot, using least‐squares approximation, relies analytically on the singular value decomposition, which in turn can be thought of as a two‐sided regression problem. Biplot geometry underlies many classical multivariate procedures, such as principal component analysis, simple and multiple correspondence analysis, discriminant analysis, and other variants of dimension reduction methods such as log‐ratio analysis. WIREs Comput Stat 2012 doi: 10.1002/wics.1200This article is categorized under:

Statistical and Graphical Methods of Data Analysis > Dimension Reduction
Statistical Learning and Exploratory Methods of the Data Sciences > Exploratory Data Analysis
Statistical and Graphical Methods of Data Analysis > Multivariate Analysis
Statistical and Graphical Methods of Data Analysis > Statistical Graphics and Visualization
Open Abdomen Treatment with Dynamic Sutures and Topical Negative Pressure Resulting in a High Primary Fascia Closure Rate
Authors: Kafka‐Ritsch Reinhold , Zitt Matthias , Schorn Nina , Stroemmer Sebastian , Schneeberger Stefan , Pratschke Johann , Perathoner Alexander 
Published: April 2012

AbstractBackgroundOpen abdomen (OA) treatment with negative‐pressure therapy is a novel treatment option for a variety of abdominal conditions. We here present a cohort of 160 consecutive OA patients treated with negative pressure and a modified adaptation technique for dynamic retention sutures.MethodsFrom May 2005 to October 2010, a total of 160 patients—58 women (36 %); median age 66 years (21–88 years); median Mannheim peritonitis index 25 (5–43) underwent emergent laparotomy for diverse abdominal conditions (abdominal sepsis 78 %, ischemia 16 %, other 6 %).ResultsHospital mortality was 21 % (13 % died during OA treatment); delayed primary fascia closure was 76 % in the intent‐to‐treat population and 87 % in surviving patients. Six patients required reoperation for abdominal abscess and five patients for anastomotic leakage; enteric fistulas were observed in five (3 %) patients. In a multivariate analysis, factors correlating significantly with high fascia closure rate were limited surgery at the emergency operation and a Björk index of 1 or 2; factors correlating significantly with low fascia closure rate were male sex and generalized peritonitis.ConclusionsWith the aid of initially placed dynamic retention sutures, OA treatment with negative pressure results in high rates of delayed primary fascia closure. OA therapy with the technical modifications described is thus considered a suitable treatment option in various abdominal emergencies.