bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peak Studio: a tool for the visualization and analysis of fragment analysis files
Authors: McCafferty Jonathan , Reid Robert , Spencer Melanie , Hamp Timothy , Fodor Anthony 
Published: July 2012

SummaryWhile emerging technologies such as next‐generation sequencing are increasingly important tools for the analysis of metagenomic communities, molecular fingerprinting techniques such as automated ribosomal intergenic spacer analysis (ARISA) and terminal restriction fragment length polymorphisms (T‐RFLP) remain in use due to their rapid speed and low cost. Peak Studio is a java‐based graphical user interface (GUI) designed for the visualization and analysis of fragment analysis (FSA) files generated by the Applied Biosystems capillary electrophoresis instrument. Specifically designed for ARISA and T‐RFLP experiments, Peak Studio provides the user the ability to freely adjust the parameters of a peak‐calling algorithm and immediately see the implications for downstream clustering by principal component analysis. Peak Studio is fully open‐source and, unlike proprietary solutions, can be deployed on any computer running Windows, OS X or Linux. Peak Studio allows data to be saved in multiple formats and can serve as a pre‐processing suite that prepares data for statistical analysis in programs such as SAS or R.
Psychological effects of dance‐based group exergaming in obese adolescents
Authors: Wagener T. L. , Fedele D. A. , Mignogna M. R. , Hester C. N. , Gillaspy S. R. 
Published: July 2012

SummaryBackgroundIn order to attract obese adolescents who are often reluctant to engage in traditional exercise, new forms of physical activity are needed.ObjectivesThe purpose of the study was to investigate the impact of dance‐based exergaming on a diverse sample of obese adolescents' perceived competence to exercise, psychological adjustment and body mass index (BMI).MethodsA diverse sample of 40 obese adolescents was randomized to either a 10‐week group dance‐based exergaming programme or a wait‐list control condition. Baseline and follow‐up measures included adolescent self‐reported psychological adjustment and perceived competence to exercise, and maternal report of adolescent psychological adjustment and anthropometric measures.ResultsCompared with controls, participants in the dance‐based exergaming condition significantly increased in self‐reported perceived competence to exercise regularly and reported significant improvement in relations with parents from baseline to end‐of‐treatment. Maternal report of adolescent externalizing and internalizing symptomatology also decreased from baseline to end‐of‐treatment. No pre‐post differences in BMI were seen within or between conditions.ConclusionsResults support the positive impact of dance‐based exergaming on obese adolescents' psychological functioning and perceived competence to continue exercise.
ENSO Drove 2500-Year Collapse of Eastern Pacific Coral Reefs
Authors: Toth Lauren T. , Aronson Richard B. , Vollmer Steven V. , Hobbs Jennifer W. , Urrego Dunia H. , Cheng Hai , Enochs Ian C. , Combosch David J. , van Woesik Robert , Macintyre Ian G. 
Published: July 2012

A Long CollapseCoral reefs are threatened by global warming and ocean acidification, and so it is important to understand better how and why environmental changes have affected them in the past.Tothet al.(p.81) present a 6000-year-long record of coral reefs off the coast of Panama, Central America. The reefs effectively stopped growing for approximately 2600 years, beginning around 4000 years ago. This collapse of the coral reef system was probably caused by increased variability of ENSO, the El Nino–Southern Oscillation. If the strength or frequency of ENSO were to increase, the viability of these and other reef systems in the Pacific could be put further at risk.
Eccentric strengthening effect of hip-adductor training with elastic bands in soccer players: a randomised controlled trial
Authors: Jensen Jesper , Hölmich Per , Bandholm Thomas , Zebis Mette K , Andersen Lars L , Thorborg Kristian 
Published: July 2012

BackgroundSoccer players with weak hip-adductor muscles are at increased risk of sustaining groin injuries. Therefore, a simple hip-adductor strengthening programme for prevention of groin injuries is needed.ObjectiveWe aimed to investigate the effect of an 8-week hip-adductor strengthening programme, including one hip-adduction exercise, on eccentric and isometric hip-adduction strength, using elastic bands as external load.MethodsThirty-four healthy, sub-elite soccer players, mean (±SD) age of 22.1 (±3.3) years, were randomised to either training or control. During the mid-season break, the training group performed 8 weeks of supervised, progressive hip-adduction strength training using elastic bands. The participants performed two training sessions per week (weeks 1–2) with 3×15 repetition maximum loading (RM), three training sessions per week (weeks 3–6) with 3×10 RM and three training sessions per week (weeks 7–8) with 3×8 RM. Eccentric hip-adduction (EHAD), isometric hip-adduction (IHAD) and isometric hip-abduction (IHAB) strength, and the IHAD/IHAB ratio were measured assessor-blinded preintervention and postintervention, using reliable hand-held dynamometry procedures.ResultsIn the training group, EHAD strength increased by 30% (p<0.001). In the control group, EHAD strength increased by 17% (p<0.001), but the increase was significantly larger in the training group compared with the control group (p=0.044). No other significant between-group strength-differences in IHAD, IHAB or the IHAD/IHAB ratio existed (p>0.05).Conclusions8 weeks of hip-adduction strength training, using elastic bands, induce a relevant increase in eccentric hip-adduction strength in soccer players, and thus may have implications as a promising approach towards prevention of groin injuries in soccer.
O-013 The pulsar vascular aneurysm neck reconstruction device for bifurcation aneurysms: in vitro study and first clinical experience: Abstract O-013 Figure 1
Authors: Tateshima S , Turk A , Ceratto R , Ferrario A , Lylyk P 
Published: July 2012

IntroductionWe present the in vitro and first clinical results of a novel aneurysm neck reconstruction device specifically designed to treat bifurcation aneurysms.MethodThe Pulsar Vascular Aneurysm Neck Reconstruction Device (ANRD) is a T-shaped, self-expanding, permanent implant made of nitinol with a uniquely open architecture that maintains the luminal patency of two bifurcation branches while holding a coil mass in place in the aneurysm. Utilizing in vitro aneurysm models, the following design aspects of the ANRD were optimized prior to first-in-man (FIM) use: number of nitinol struts, location of radiopaque markers, ability to position and reposition the device, pushability and microcatheter compatibility. Once the design of the ANRD was optimized and the safe delivery technique was established, the first clinical case was performed. Inclusion criteria for FIM cases includes unruptured, wide-necked intracranial aneurysms located at the basilar tip or carotid terminus with a diameter of the basilar or carotid artery appropriate for the device sizes available. FIM candidate cases were reviewed and approved by scientific advisory board members as well as the operator prior to the procedure. Clinical use of the ANRD was approved on a case-by-case basis.ResultsUnder fluoroscopic guidance, ANRDs of various sizes and designs were deployed in two basilar tip aneurysm models. The final version of the ANRD could be safely deployed in the models and the operator could steer the T-shaped device into both posterior cerebral arteries (PCAs). Following extensive in vitro testing and animal studies, the ANRD was successfully deployed in the first clinical cases. The FIM case was a female with an incidental basilar tip aneurysm, projecting anteriorly, measuring 10.3 mm in the largest diameter and 7.3 mm in the neck. Both PCAs were incorporated in the base of the aneurysm. One ANRD was delivered via a Marksman microcatheter and successfully placed at the neck of the basilar tip aneurysm. Coiling procedure was performed immediately after the placement of the ANRD. Immediate post coiling angiogram showed the tight packing of the aneurysm and the patency of both PCAs. The ANRD was stable during the coiling procedure without any radiographic signs of proximal migration by the pressure of the coil mass.ConclusionThe Pulsar Vascular ANRD provides excellent support to achieve tight coil packing in bifurcation wide-necked aneurysms. The FIM experience demonstrates the safety and feasibility of the ANRD concept. Results in the first group of patients including follow-up will be presented.Competing interestsS Tateshima: Pulsar Vascular. A Turk: Pular Vascular. R Ceratto: None. A Ferrario: None. P Lylyk: None.Abstract O-013 Figure 1
O-016 Radiation exposure during cerebral angiography and neuroembolization in children: analysis of 357 consecutive cases
Authors: Lin N , Manchester J , Smith E , Scott M , Orbach D 
Published: July 2012

Introduction/PurposeCatheter-based cerebral angiography and embolization are important tools in managing cerebrovascular diseases in the pediatric population. We concurrently present data on the safety of pediatric neurointervention, demonstrating an overall low complication rate associated with such procedures in children, regardless of age group. However, radiation exposure during neurointerventional procedures in the pediatric population is of particular importance and merits dedicated study.Materials and MethodsRecords for all pediatric patients who underwent cerebral angiography and/or neuroembolization from 2007 through 2009 were retrospectively reviewed. Radiation skin entry dose data were obtained from fluoroscopic suites equipped with built-in cumulative dose (air kerma) and dose-area-product (DAP) measurement capability.ResultsOf the 357 consecutive procedures performed from 2007 through 2009, 214 were diagnostic angiograms and 143 involved embolization. Mean age was 9.5 years (range: 4 days to 18 years), and 193 were female. The interventional procedures included intracranial (77), extracranial (57), and spinal (9) embolizations. The pathology requiring neurointervention included intracranial arteriovenous malformation (AVM, 15), spinal AVM (8), aneurysms (15), Vein of Galen Malformation (VOGM, 19), intracranial arteriovenous fistula (AVF, 21), facial and extracranial AVM (46), tumor (11), stroke (2), and others (6). Overall, the observed cumulative dose and DAP correlated well (r=0.87). The average cumulative skin entry dose for the cohort was 365.9 mGy (range: 21–2707 mGy). Radiation exposure during neurointervention was significantly higher than during diagnostic angiography (566.3 and 191.0 mGy, respectively, p<0.001). Patients with spinal AVM (939.8 mGy), aneurysms (777.5 mGy), and AVF (730.5 mGy) received higher doses of radiation. During the mean follow-up period of 2.1 years, one short-term complication (transient hair loss) related to radiation was noted.ConclusionRelative to previous reports related to neurointerventions in adults and to complex, non-neuro pediatric interventions, radiation exposure during cerebral angiography and embolization was moderate, and the short-term risk associated with radiation was low. It will be of importance, going forward, to track the long-term effects of radiation exposure related to pediatric neurointerventions in this cohort, requiring conversion of skin entry doses to brain organ dose.Competing interestsNone.
O-005 Multicenter experience utilizing CT perfusion guided patient selection for intra-arterial thrombectomy: Abstract O-005 Table 1
Authors: Turk A , Frei D , Fargen K , Magarik J , Chaudry I , Huddle D , Mocco J , Bellon R , Turner R 
Published: July 2012

BackgroundTraditional treatment in acute ischemic stroke is based on time criteria when administering intravenous and intra-arterial therapies. However recent evidence suggests that image based criteria may be useful for selecting patients for intra-arterial interventions. We investigated CT perfusion (CTP) based criteria, regardless of time from symptom onset, in patient selection for intra-arterial treatment of ischemic stroke.MethodsWe retrospectively assessed ischemic stroke patients who presented to the Medical University of South Carolina, the University of Florida Medical Center, and Swedish Medical Center in Denver, over the last 4 years, with a National Institute of Health Stroke Scale (NIHSS) score of ≥8, regardless of time from symptom onset. CTP maps were qualitatively assessed for presence of penumbra and infarction. Selected patients underwent mechanical thrombectomy of their occlusion, nearly all using the Penumbra Aspiration System. We then recorded functional outcome using the modified Rankin scale at 90 days or closest follow-up to 90 days. We will continue to update this data until time of presentation.Results271 patients were included in the study. The median time from symptom onset to groin access in all patients was 6.0 h and patients were therefore divided into two groups based on that time point. Overall, 52 patients (19.9%) had bleeding complications, including subarachnoid hemorrhage, parenchymal hemorrhage and intraventricular hemorrhage, but only 12% were symptomatic. After CTP based selection patients were divided into two groups for analysis: ≤6 h and >6 h from symptom onset to endovascular procedure. We found no significant difference in functional outcome between the two groups 43% and 43.2% that achieved 90-day mRS ≤2, respectively (p=1.0), and 60.5% vs 55.3% (p=0.8) that achieved 90-day mRS ≤3, respectively. We found no difference in the rate of intracranial hemorrhage between the two groups 21% vs 17.3% (p=0.704), respectively.ConclusionOur study demonstrated similar rates of good functional outcome and intracranial hemorrhage in ischemic stroke patients when endovascular treatment was performed based on CTP selection rather than time-guided selection. Our findings suggest that endovascular reperfusion in ischemic stroke may be effective and safe when imaging based paradigms are followed, and may allow patient selection not solely based on time from symptom onset.Competing interestsA Turk: Stryker, Pulsar Vascular. Penumbra, Stryker, Siemens, Codman, Microvention, eV3, NFocus, Pulsar Vascular, Lazarus Effect. D Frei: Penumbra. K Fargen: None. J Magarik: None. I Chaudry: Penumbra. D Huddle: None. J Mocco: Penumbra, Stryker. Penumbra, Stryker. R Bellon: None. R Turner: Penumbra.Abstract O-005 Table 1≤6 h>6h 90-day mRS 0–2 (%)4343.290-day mRS 0–3 (%)60.555.3Hemorrhage on CT (%)2117.3NIHSS18.515.7Age66.365.5Median/Mean time to start4.0/4.0 h9.5/13.7 h
P-036 Analysis of events reported in the MAUDE database comparing neuroform, enterprise, and pipeline devices
Authors: Klucznik R 
Published: July 2012

Introduction/PurposeWe report on data in the Manufacturer and User Facility Device Experience (MAUDE) database for Neuroform (Boston Scientific), Enterprise (Cordis), and Pipeline (Covidien) devices with a focus on a 6-month period.Materials and MethodsAll events reported from May 31, 2011 to December 30, 2011 in the MAUDE database were collected for Neuroform, Enterprise, and Pipeline devices. Results were analyzed for extent of injuries and device malfunctions reported.ResultsIn summary, the combined Neuroform and Enterprise MAUDE reports showed that there were 73 events reported between May 31 and December 30, 2011. Four deaths were reported during the time period examined (5% of reports); of these, three reports stated that event date was unknown and one was reported as not device-related. SAH developed as a complication during Enterprise-stent assisted embolization of one aneurysm, and the patient subsequently died. Injuries described in the reports included two post-treatment bleeds (2.7% of reports), 10 occlusions (13.7%) and four SAH (5% of reports), one of which was associated with disability and one of which is associated with death of unknown event date. Device malfunctions were indexed in 41% of the reports, including four which were described as catheter or strut separation/breaks (5% of reports), 14 were delivery system failures (19% of reports) and four were fractures (5% of reports). The Pipeline MAUDE reports showed that there were 71 events reported during May 31 to December 30, 2011. Thirteen deaths were reported during the time period examined (18% of reports); eight deaths involved peri-procedural or post-treatment bleeds (62% of reported deaths). Injuries described in the reports include 12 post-treatment bleeds (17% of reports) and four SAHs (6% of reports), all of which are associated with death. The number of device malfunctions reported includes 38 failures to deploy (54% of reports) with associated 29 ballooning procedures (41% of reports) and nine broken push wires (13% of reports).ConclusionFor the 6-month period examined, events such as death, serious injury, and device malfunctions were reported in the MAUDE database. Even though the total number of reports comparing Neuroform/Enterprise and Pipeline were comparable, number of deaths related to Pipeline were more than three times higher. Due to lack of data regarding total number of patients treated during the time period examined, adverse event occurrence rates across devices cannot be compared. Further data and discussion are warranted to understand these initial observations.Competing interestsNone.
P-044 Safety of neuroangiography and neurointerventions in children: complication analysis in 509 consecutive cases
Authors: Lin N , Smith E , Scott M , Orbach D 
Published: July 2012

Introduction/purposeCatheter-based cerebral angiography and embolization and related techniques are important tools in the management of cerebrovascular diseases in the pediatric population. While two series reporting complication rates for pediatric diagnostic cerebral angiography have been published, a similar analysis for neurointerventional procedures in children is not available.Materials and MethodsRecords for all pediatric patients who underwent cerebral angiography and/or neurointerventions from January 1, 2007 to December 31, 2010 were retrospectively reviewed to identify both intra-procedural and post-procedural complications. Events were categorized as transient non-neurological, long-term non-neurological, transient neurological and long-term neurological complications. Demographic and clinical risk factors for developing a complication were analyzed with a multivariate logistic regression model.ResultsOf the 509 consecutive procedures performed by the senior author from 2007 through 2010, 304 were diagnostic angiograms and 205 were interventions. Mean age was 9.2 years (range: 4 days – 18 years), and the female to male ratio was 1.02. The interventional procedures included intracranial (85), extracranial (80), and spinal (13) embolizations, as well as sclerotherapy (27). Underlying pathology for the transarterial/transvenous interventions included Vein of Galen Malformation (23), intracranial AVM (21), intracranial AVF (17), aneurysms (16), spinal AVM (11), tumor (13), acute stroke (5), facial and extracranial AVM (53), extracranial AVF (10) and others (9). Pathologies for the sclerotherapy included venous and lymphatic malformations of the head and neck (27). Overall, zero intra-procedural and three post-procedural complications (0.99%) occurred in the diagnostic group, all of which were short-term, non-neurological events. In the interventions group, eight intra-procedural and six post-procedural complications (6.8%) were observed. There were four purely technical complications, with no clinical consequence (1.9%), four short-term non-neurological events (1.5%), three short-term neurological events (0.98%), and two long-term neurological events (0.98%): one patient developed intracerebral hemorrhage after embolization of an intracranial AVM, and another patient (a syndromic dwarf with moyamoya) had an acute infarct during aneurysm coiling. Multivariate analysis revealed that tumor embolization was associated with higher likelihood of complication than other groups of patients. There was no association between the age of the patient and the likelihood of adverse events. There were no vessel dissections or ruptures and no long-term femoral artery sequelae.ConclusionsWe report safety data on the largest pediatric neurointerventional cohort to date. At a high volume pediatric neurovascular center, the complication rates for neuroangiography and embolization are low; in particular, non-transient adverse events are rare.Competing interestsNone.
E-023 Interventional approaches to tandem internal carotid artery/middle cerebral artery occlusions treated with carotid angioplasty vs stenting: a case series and discussion: Abstract E-023 Table 1
Authors: Telischak N , Zarzour H , Dinobile D , Frerichs K , Thomas A , Selim M , Reddy A 
Published: July 2012

We report on the techniques of simultaneous carotid artery angioplasty and/or stenting with intracranial thrombectomy and/or thrombolysis in the treatment of acute stroke due to tandem ICA/MCA occlusion. A review of the interventional neuroradiology patient database of two major teaching hospitals (Beth Israel Deaconess Medical Center and Brigham and Women's Hospital, Boston, Massachusetts, USA) yielded five cases from the past 2 years of treatment of tandem ICA/MCA occlusion. Five patients presented to our hospitals between 12/2008 and 12/2010 (mean age: 65.8, range 48–84 years) with acute stroke (mean NIHSS: 18, range 8–24) and were found to have tandem ICA/MCA occlusion (Abstract E-023 table 1). Definitive interventional neuroradiology treatment (mean time from symptom onset to catheterization: 168 min, range 100–251 min) either treated with carotid artery angioplasty (N=2), or angioplasty and stent placement (N=3) combined with intracranial intra-arterial thrombolysis and/or mechanical clot retrieval. Procedures were technically successful in opening the ICA occlusion in all cases, with variable results in intracranial thrombectomy/thrombolysis ranging from complete revascularization to residual M1 branch MCA occlusion. All patients survived to hospital discharge with residual neurologic deficits. We review treatment options of carotid angioplasty alone vs angioplasty and stent placement, in addition to intracranial thrombolysis and mechanical thrombectomy, and discuss potential pitfalls to these approaches.Abstract E-023 Table 1Patient presentation characteristics, success of intervention, and outcomesPatientTime from symptom onset (hours)Successful ICA revascularizationSuccessful M1 segment revascularizationNIHSS before interventionDischarge statusPatient 15.0YesYes19Inpatient RehabilitationPatient 21.2YesYes22Home with hospicePatient 31.0YesNo17Inpatient RehabilitationPatient 4UnknownYesNo24Home with hospicePatient 51.2YesYes8Inpatient RehabilitationCompeting interestsNone.