bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arginine Methylation by PRMT1 Affects ADAMTS13 Secretion and Enzymatic Activity
Authors: Liu Szumam , Ma Min , Qu Jun , Muia Joshua , Wu Zhijian , Bonnez Quintijn , Vanhoorelbeke Karen , Zheng Liang , Zhao Xinyang , Zheng X. Long 
Published: February 2025

BACKGROUND:
ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, 13), primarily synthesized in hepatic stellate and endothelial cells, plays a pivotal role in the regulation of hemostasis by proteolytic cleavage of von Willebrand factor. Severe deficiency of plasma ADAMTS13 activity may result in thrombotic thrombocytopenic purpura, a potentially fatal blood disorder. ADAMTS13 undergoes posttranslational modifications including glycosylation, citrullination, oxidation. The present study determines the impact of arginine methylation by PRMT1 (protein arginine methyltransferase 1) on ADAMTS13 secretion and function.

METHODS:
Cell culture, recombinant protein, biochemical analysis, site-directed mutagenesis, and animal models were utilized.

RESULTS:
An inhibition of arginine methylation by a PRMT inhibitor (a type I methyl transferase inhibitor, MS023) in human embryonic kidney 293 cells expressing recombinant ADAMTS13 and mice results in a significant reduction of ADAMTS13 secretion, but the secreted ADAMTS13 shows an increased specific activity; conversely, overexpression of PRMT1 in human embryonic kidney 293 cells and mice results in an increase of ADAMTS13 secretion, but the secreted ADAMTS13 exhibits a significantly reduced proteolytic activity. The altered ADAMTS13 activity appeared to be related to its conformational changes. LC-MS/MS identified >100 arginine methylation events on recombinant ADAMTS13. Site-directed mutagenesis of 5 highly conserved methylation sites (R193, R498, R692, R1123, and R1206) identifies the critical role of R1206 in ADAMTS13 function. The R1206K variant exhibits a 4- to 5-fold increase of ADAMTS13 activity, likely resulting from an alleviation of allosteric inhibition.

CONCLUSIONS:
These results demonstrate the crucial role of arginine methylation on ADAMTS13 secretion and activity. Our findings may shed new light on the mechanism of allosteric regulation of ADAMTS13, which may have a therapeutic implication.
Novel Directly Reprogrammed Smooth Muscle Cells Promote Vascular Regeneration as Microvascular Mural Cells
Authors: Jung Cholomi , Han Ji Woong , Lee Shin-Jeong , Kim Kyung Hee , Oh Jee Eun , Bae Seongho , Lee Sangho , Nam Young-Jae , Kim Sangsung , Dang Chaewon , Kim Jaehyun , Chu Nakhyung , Lee Eun Jig , Yoon Young-sup 
Published: February 2025

BACKGROUND:
Although cell therapy has emerged as a promising approach to promote neovascularization, its effects are mostly limited to capillaries. To generate larger or stable vessels, layering of mural cells such as smooth muscle cells (SMCs) or pericytes is required. Recently, direct reprogramming approaches have been developed for generating SMCs. However, such reprogrammed SMCs lack genuine features of contractile SMCs, a native SMC phenotype; thus, their therapeutic and vessel-forming potential in vivo was not explored. Therefore, we aimed to directly reprogram human dermal fibroblasts toward contractile SMCs (rSMCs) and investigated their role for generating vascular mural cells in vivo and their therapeutic effects on ischemic disease.

METHODS:

We applied myocardin and all-
trans
retinoic acid with specific culture conditions to directly reprogram human dermal fibroblasts into rSMCs. We characterized their phenotype as contractile SMCs through quantitative reverse-transcriptase polymerase chain reaction, flow cytometry, and immunostaining. We then explored their contractility using a vasoconstrictor, carbachol, and through transmission electron microscope and bulk RNA sequencing. Next, we evaluated whether transplantation of rSMCs improves blood flow and induces vessel formation as mural cells in a mouse model of hind-limb ischemia with laser Doppler perfusion imaging and histological analysis. We also determined their paracrine effects.

RESULTS:

Our novel culture conditions using myocardin and all-
trans
retinoic acid efficiently reprogrammed human dermal fibroblasts into SMCs. These rSMCs displayed characteristics of contractile SMCs at the mRNA, protein, and cellular levels. Transplantation of rSMCs into ischemic mouse hind limbs enhanced blood flow recovery and vascular repair and improved limb salvage. Histological examination showed that vascular density was increased and the engrafted rSMCs were incorporated into the vascular wall as pericytes and vascular SMCs, thereby contributing to formation of stabler and larger microvessels. Quantitative reverse-transcriptase polymerase chain reaction analysis revealed that these transplanted rSMCs exerted pleiotropic effects, including angiogenic, arteriogenic, vessel-stabilizing, and tissue regenerative effects, on ischemic limbs.

CONCLUSIONS:

A combination of myocardin and all-
trans
retinoic acid in defined culture conditions efficiently reprogrammed human fibroblasts into contractile and functional SMCs. The rSMCs were shown to be effective for vascular repair and contributed to neovascularization through mural cells and various paracrine effects. These human rSMCs could represent a novel source for cell-based therapy and research.
Interview: Breaking the Monolith of Russian-Language Culture
Authors: Rulyova Natasha , Ismailov Hamid 
Published: February 2025

Abstract
Hamid Ismailov is a prolific multilingual author, having written articles, stories, books of poetry and many novels in Russian, Uzbek, and English. He translated Uzbek classics into Russian, and Western and Russian literature into Uzbek. He also worked from Farsi into Russian. He was born into an Uzbek family in Tokmok, Kyrgyzstan, in 1954. He was educated in a Soviet secondary school and then military college. As a child, he read classical poetry and One Thousand and One Nights to his grandmother, who brought him up from the age of twelve. As an adult, Ismailov lived in Tashkent and then in Moscow where he championed Uzbek literature for the Writers Union. In 1992, he was forced to leave Uzbekistan because his poetry was found to be too “decadent,” but he later returned. In 2017, he was deported from Tashkent airport. His novels are still banned in Uzbekistan. After moving to western Europe, he lived in France for a short period of time and then moved to England where he worked at the bbc for twenty-five years. He was the first bbc Central Asia correspondent. In May 2010, he was appointed bbc World Service Writer-in-Residence and continued in this position until 2014. He currently lives in Prague.
Natasha Rulyova studied Joseph Brodsky’s bilingualism and self-translation. She is now working on a project on Russophone Literary Diversity. She discusses with Ismailov his literary multilingualism, translation, postcolonial writers’ stereoscopic vision and his mission to diversify Russian-language culture. This written interview is based on Rulyova’s conversation with Ismailov, which took place online in English as part of the series “Natasha Rulyova’s Conversations with Russophone Authors,” co-organized with Pushkin House, London, on October 24, 2023 (available on the Pushkin House YouTube channel at www.youtube.com/watch?v=YXZSGoEx03U).
Revisiting short finger and cleft type symbrachydactyly subtype differentiation utilizing the congenital upper limb differences (CoULD) registry
Authors: Landes Emma , Goldfarb Charles A. , James Michelle , Bohn Deborah , Bauer Andrea , Wall Lindley B. ,   CoULD Study Group
Published: February 2025

The purpose of this investigation was to investigate short finger and cleft type symbrachydactyly to identify the defining features of these two subtypes. This retrospective study extracted data from the Congenital Upper Limb Differences (CoULD) Registry. Five paediatric hand surgeons reviewed photographs and radiographic imaging to evaluate the characteristics of each subtype and the reliability of diagnosis and evaluated the recorded diagnosis in the registry. Final analysis included 50 short finger and 54 cleft type symbrachydactyly. Key characteristic patterns were identified for each type, with further subdivision of subtypes with notable hypoplasia of the index or ring fingers or all digits. Consensus was obtained (inter-rater reliability 78%) and reliably applied for these unique subclassifications. While no clear trend in increasing severity was identified for these two subgroups of symbrachydactyly, this re-classification exercise provides clearer definition of the different subtypes and may give insight into the developmental biology of these conditions, predict future clinical function and guide surgical outcomes. Level of evidence: IV
Housing Status and Healthcare Utilization in People Presenting With Seizure
Authors: Mullady Sandeepa S. , Wood Andrew J. , Guterman Elan L. , Rosendale Nicole 
Published: February 2025

Objective To examine the association between housing status and healthcare utilization in individuals presenting with seizure. Methods We performed a retrospective cross-sectional analysis of all adults (age >18) presenting to a public hospital emergency department with seizures, defined by ICD-9/10 codes, between 1/1/2016 and 8/03/2019. They were categorized by housing status (people experiencing homelessness [PEH], people with housing). Healthcare utilization outcomes were 30-day re-visit to acute care, discharge disposition, and hospital length of stay for those admitted. We used multivariable linear and logistic regression models adjusting for age, comorbidities, and insurance status. Results There were 6483 individuals (2092 [32.3%] PEH). Compared to people with housing, PEH were younger (48.2 vs 50.9, P < .0001), more likely to be a person of color (80.9 vs 75.1%, P < .0001), and have Medicaid (51.4% vs 42.9%, P < .0001). People with housing had a higher prevalence of admission to the intensive care unit (3.6% vs 1.8%, P < .0001). After adjustment, admitted PEH had higher odds of 30-day re-visit (adjusted odds ratio [aOR] 1.87, 95% confidence interval [CI] 1.58, 2.21), shorter length of stay (coef Β-12.87, 95% CI: −22.62, −3.11), and lower odds of being discharged to a facility (aOR 0.37, 95% CI: .26, .55) compared to people with housing. Conclusion and Relevance PEH with seizures had increased healthcare utilization. Further analysis, including imaging findings, anti-seizure medications prescribed, and presumed etiology, is needed to understand the drivers of healthcare utilization and identify appropriate interventions.
Fatigue in multiple sclerosis: A scoping review of pharmacological and nonpharmacological interventions
Authors: Diaz-Quiroz Mateo , Chicue-Cuervo Paula Catalina , Garcia-Moreno Luna , Gaviria-Carrillo Mariana , Talero-Gutierrez Claudia , Palacios-Espinosa Ximena 
Published: February 2025

Introduction Fatigue is a highly prevalent symptom in people with multiple sclerosis. It demands careful assessment and prompt intervention to improve their quality of life and overall burden of disease. This scoping review aims to provide a comprehensive synthesis and update of the existing evidence on the effectiveness of different pharmacological and nonpharmacological interventions for multiple sclerosis (MS)-related fatigue. Methods To ensure the transparency and quality of the articles chosen for this scoping review, the Preferred Reporting Items for Systematic Reviews and Meta-analysis Protocols extension for Scoping Reviews was used. Exclusively randomized controlled trials published between 2016 and 2023 were included. Results Twenty-eight articles were analyzed. We found that pharmacological interventions are few and have included the use of Amantadine, Ondansetron, Methylphenidate, and Modafinil, with little effects on fatigue. Nonpharmacological interventions are diverse and include cognitive behavioral therapy, guided imagery, phototherapy, exercise, brain stimulation, and lavender administration with evidence of a statistically significant decrease in fatigue. Conclusions and Discussion Current evidence on the effectiveness of pharmacological and nonpharmacological interventions is inconclusive. Lack of knowledge of the pathophysiology of fatigue limits its prevention, control, and management recommendations. A comprehensive and interdisciplinary approach is required to manage this symptom in patients with MS.
The influence of strategic foresight on quality of healthcare services in the presence of artificial intelligence solutions in Jordan
Authors: Alajrab Salma Sami , Oweidat Islam Ali , Nassar Omaima , ALBashtawy Mohammed , Nashwan Abdulqadir J. 
Published: February 2025

Abstract

Background
Healthcare organizations are distinguished by intricate systems that undergo continual modifications and unpredictability. This greatly hinders the ability to estimate the exact consequences of any changes accurately. Therefore, scholars prove that strategic foresight enables leaders to anticipate future challenges and possibilities. The utilization of artificial intelligence (AI) in management is on the rise, mostly because of its ability to provide intelligent services, reduce medical errors, and improve operational efficiency.

Purpose
To examine the impact of strategic foresight on the quality of healthcare services provided by Jordanian nurses in the context of AI solutions in governmental hospitals.

Method
A cross-sectional descriptive correlational analysis was conducted. A convenience sampling approach was used in the four selected Jordanian governmental hospitals. The study’s target population consisted of nurses. Over three weeks between January and February 2024, 240 self-reported questionnaires were received using a five-point Likert scale, with a response rate of 88.9%. The completed surveys were suitable for analysis using AMOS SPSS v. 26 and SPSS.

Results
Simple linear regression and (Pearson’s r) test results showed that (R = .279, R square = 0.078) between strategic foresight and the quality of healthcare services. (R = .543, R square = 0.295) between strategic foresight and the adoption of AI-based solutions. And (R = .432, R square = 0.187) between adopting AI-based solutions and the quality of healthcare services. That reveals a statistically significant, positive correlation coefficient relationship between the variables. In the presence of the mediator, the direct relationship between strategic foresight and healthcare service quality was not statistically significant (b = 0.063, p = .398). The path analysis test indicates a linear relationship between the variables sequentially, and the AI-based solutions completely mediate the relationship between strategic foresight and the quality of healthcare services.

Conclusions
A positive and significant correlation between the variables suggests that a simulation-proposed model for a healthcare quality forecasting system, which the researcher built and included in the study recommendations, has to be designed. Therefore, AI-based forecasting systems should incorporate health service quality parameters to facilitate high efficiency and prompt patient demand fulfillment.
The effect of parental psychological flexibility on children’s behavioral problems: a moderated mediation model
Authors: Wang Jia , Liu Ru-De , Lin Jingmin 
Published: February 2025

Abstract

Background
Building upon previous research suggesting that parental psychological flexibility is negatively associate with children’s behavioral problems, this study examined a moderated mediation model to explore the effect of parental psychological flexibility on children’s internalizing and externalizing problems. Specifically, parent-child conflict is considered as a mediator while parental phubbing is examined as a moderator.

Methods
This study employed a cross-sectional design, with a total of 1060 parents of preschool-aged children participating. The parents completed a series of surveys, including the Parental Psychological Flexibility Questionnaire, the short form of the Child–Parent Relationship Scale, the Parental Phubbing Scale, and the Strengths and Difficulties Questionnaire regarding their children. The moderated mediation model was assessed using SPSS PROCESS 4.1.

Results
The results indicated that parental psychological flexibility negatively predicted children’s behavioral problems through the mediating effect of parent-child conflict, with this relationship being moderated by parental phubbing; an increase in phubbing weakened the negative correlation between parental psychological flexibility and parent-child conflict, thereby further weakened the negative correlation between parental psychological flexibility and children’s behavioral problems.

Conclusion
These findings offer potential strategies for parents to mitigate the risk of their children developing internalizing or externalizing problems, by enhancing parental psychological flexibility and reducing instances of phubbing behavior.
Optimizing in-store warehouse safety: A DEMATEL approach to comprehensive risk assessment
Authors: Esmaeili Sayed Vahid , Alboghobeish Ali , Yazdani Hosein , Ghasemi Koozekonan Aysa , Pouyakian Mostafa 
Published: February 2025

Introduction
In-store warehouses can be a dangerous place due to the storage of a high volume of diverse life goods which may raise the total risk of warehouse. The turnover of goods in this kind of warehouse is very high. Therefore, safety risk is a multi-criteria problem and risk assessment of a such dynamic place needs an accurate and simple method to use. This study was conducted to design and validation of a method for risk assessment of in-store warehouses using the DEMATEL method.

Materials & methods
This cross-sectional descriptive analytical study was conducted between 2015 to 2016. First, a preliminary questionnaire was prepared by reviewing the available studies and documents. After assigning the group of experts and validating the questionnaire base on the content validity index (CVI) and content validity ratio (CVR), the weight of each of the parameters affecting the safety of the warehouse was determined. Then, the risk calculation model was developed. This model was validated using the failure modes and effects analysis (FMEA) method and Bland-Altman statistical method. Finally, to simplify the use of the developed risk assessment method, the algorithm of the model was also created.

Results
The results showed that 21 factors are among the main factors affecting the safety of the in-store warehouse, among which the "igniting and explosive property of the goods" factor had the most impact and the "warehouse working hours" factor had the least impact. The results achieved from the designed model were consistent with the FMEA method.

Conclusion
Based on the results, the newly designed risk assessment method can analyze the risks in the in-store warehouses faster and more accurately than the existing methods.
Cooperation of internal and external audit
Authors: Zabawa Gabriela 
Published: February 2025

This article addresses the issue of cooperation between internal and external auditing, their similarities and differences, as well as the areas in which they complement each other. It presents the main assumptions and objectives of audits, their functions and shows the importance of integrating both of audits to increase company efficiency and thoroughly examine purposefulness and correctness of ongoing processes.Â Â
Physico-chemical characteristic of gorewada lake water in Nagpur, India
Authors: . Salahuddin 
Published: February 2025

Â The proper control and appraisal of lake water condition and its purification is very crucial for appropriate care and management purposes. Water quality checking and investigation of the Gorewada Lake was implemented for numerous physico-chemical parameters in the month of June, 2016.These components are: (i) pH, (ii) Temperature, (iii) Electric Conductivity, (iv) Dissolved Oxygen, (v) Biochemical Oxygen Demand, (vi) Chemical Oxygen Demand, (vii) Total Phosphorous, (viii) Suspended Solid (ix) and Total Nitrogen respectively. The lake water is not suitable for drinking, bathing and other life supporting activity.Â Â
Gandhian Social work and his Constructive Programme: Contextualizing his Satayagrah for the peaceful world.
Authors: Mrinal Madhur , Kumar Upmesh 
Published: February 2025

Paper highlights three Satyagragh of Gandhiji. Champaran Satyagragh peasant movement was first Satyagragh prevailing situation of indigo planters and role of Gandhiji. It also enumerates his philosophy for world peace through global programme of nonviolence and truthfulness, constructive programs and his concept of the social work education. It concludes Gandhian principles can transform Global world for peace through Professional social work education by incorporating the Constructive Program as suggested by Gandhi. His philosophy- sataygragh, ahimsa and swadeshi are well included in Constructive Programmes for making more relevant for peace today. The social work practitioner may feel teaching and training of Social work student should be based on Constructive Programme for making Sarvodaya Society and a Sarvodaya social Order as Gandhi enshrined in his philosophy.Â Â
The essence of fair remuneration in the light of new concepts of human capital management of an employees of the company
Authors: Leputa Natalia 
Published: February 2025

In the following article the author discusses the basic terminology used to understand the concept of fair remuneration. It will address issues such as capital, human capital and the history of their creation, as well as the perception and distribution of remuneration by type and func-tion. Particular attention is paid to fair remuneration and ways of increasing an employee's human capital.Â Â
Bringing Tara Home: Can International Law Help Sri Lanka to Return the Most Revered Cultural Object from Britain?
Authors: Amarasinghe Punsara 
Published: February 2025

Abstract
Sri Lanka underwent series of colonial domination under European powers and the cultural heritages revered by the inhabitants were at perilous risk at the hands of the colonizers. Tara Devi is an icon embodying the religious and cultural uniqueness of the Buddhist civilization of Sri Lankan from the Anuradhapura era. Tara Devi was taken away during the early part of the British administration and now it is being kept in the British museum in London. This paper in an attempt in tracing the colonial injustice of the British from an international law perspective, which equally reflects the parochial realities of the prevailing eurocentrism. While tracing British claim for keeping Tara Devi at their possession, this article takes into the account of the enraging narratives international law in a decolonized context. The results arising from this work unfolds the hard realities that encompasses the Global South in attaining the justice under international legal framework.