bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual‐Responsive and Aggregation‐Induced‐Emission Probe for Selective Imaging of Infectious Urolithiasis
Authors: Li Xiangyu , Wang Qi , Hu Shanshan , Zhang Cuiyun , Zhu Zhirong , Wang Liyang , Chen Ruoyang , Song Zhiyin , Liao Hongze , Liu Qiang , Zhu Wei‐Hong 
Published: May 2024

AbstractIdentifying infected stones is crucial due to their rapid growth and high recurrence rate. Here, the calcium–magnesium dual‐responsive aggregation‐induced emission (AIE)‐active probe TCM‐5COOH (Tricyano‐methlene‐pyridine‐5COOH), distinctively engineered to distinguish high‐threat infection calculi from metabolic stones, is presented. Upon incorporation of flexible alkyl carboxyl group, TCM‐5COOH featuring five carboxyl moieties demonstrates excellent water solubility and enhanced penetration into porous infectious stones. The robust chelation of TCM‐5COOH with stone surface‐abundant Ca2+ and Mg2+ inhibits vibrational relaxation, thus triggering intense AIE signals. Remarkably, the resulting complex exhibits high insolubility, effectively anchoring within the porous structure of the infection calculi and offering prolonged illumination. Jobs’ plot method reveals similar response characteristics for Ca2+ and Mg2+, with a 1:2 coordination number for both ions. Isothermal titration calorimetry (ITC) results demonstrate higher enthalpy change (ΔH) and lower entropy change (ΔS) for the reaction, indicating enhanced selectivity compared to TCM‐4COOH lacking the alkyl carboxyl group. Synchrotron X‐ray absorption fine spectroscopy (XAFS) validates TCM‐5COOH's interaction with Ca2+ and Mg2+ at the microlevel. This dual‐responsive probe excels in identifying infectious and metabolic calculi, compatible with endoscopic modalities and laser excitation, thereby prompting clinical visualization and diagnostic assessment.
Engineering an Organic Nanoplatform for Augmented Pyroeletroimmunotherapy
Authors: Li Xingguang , Gao Meng‐Lu , Wang Shan‐Shan , Li Yu‐Long , Liu Tong‐Ning , Xiang Huijing , Liu Pei‐Nian 
Published: May 2024

AbstractPhotothermal immunotherapy has shown great promise in the treatment of tumor metastasis. However, the thermal resistance of tumor cells substantially compromises the treatment effect of photothermal immunotherapy. Herein, a high‐performance organic pyroelectric nanoplatform, tBu‐TPAD‐BF2 nanoparticles (NPs), is rationally engineered for the effective pyroelectroimmunotherapy of tumor metastasis. Biocompatible tBu‐TPAD‐BF2 NPs with excellent pyroelectric and photothermal conversion properties are constructed by assembling organic, low‐bandgap pyroelectric molecules with amphiphilic polymers. After internalization by tumor cells, treatment with tBu‐TPAD‐BF2 NPs causes an apparent temperature elevation upon near‐infrared (NIR) laser irradiation, inducing potent immunogenic cell death (ICD). Additionally, the temperature variations under alternating NIR laser irradiation facilitate reactive oxygen species production for pyroelectric therapy, thus promoting ICD activation and lowering thermal resistance. Importantly, in vivo assessments illustrate that tBu‐TPAD‐BF2 NPs in combination with NIR laser exposure notably inhibit primary and distant tumor proliferation and prominently retarded lung metastasis. RNA profiling reveals that treatment with tBu‐TPAD‐BF2 NPs markedly suppresses metastasis under NIR laser illumination by downregulating metastasis‐related genes and upregulating immune response‐associated pathways. Therefore, this study provides a strategy for designing high‐performance pyroelectric nanoplatforms to effectively cure tumor metastasis, thereby overcoming the inherent shortcomings of photothermal immunotherapy.
Targeted SERS Imaging and Intraoperative Real‐Time Elimination of Microscopic Tumors for Improved Breast‐Conserving Surgery
Authors: Wen Yu , Liu Ruoxuan , Xie Yangcenzi , Li Ming 
Published: May 2024

AbstractBreast‐conserving surgery is the favorable option for breast cancer patients owing to its advantages of less aggressiveness and better cosmetic outcomes over mastectomy. However, it often suffers from postsurgical lethal recurrence due to the incomplete removal of microscopic tumors. Here, a surface‐enhanced Raman scattering (SERS) surgical strategy is reported for precise delineation of tumor margins and intraoperative real‐time elimination of microscopic tumor foci, which is capable of complete surgical removal of breast tumors and significantly improve the outcomes of breast‐conserving surgery without local tumor recurrence. The technique is chiefly based on the human epidermal growth factor receptor 2 (HER2)‐targeting SERS probes with integrated multifunctionalities of ultrahigh sensitive detection, significant HER2 expression suppression, cell proliferation inhibition, and superior photothermal ablation. In a HER2+ breast tumor mouse model, the remarkable capability of the SERS surgical strategy for complete removal of HER2+ breast tumors through SERS‐guided surgical resection and intraoperative real‐time photothermal elimination is demonstrated. The results show complete eradiation of HER2+ breast tumors without local recurrence, consequently delivering a 100% tumor‐free survival. Expectedly, this SERS surgical strategy holds great promise for clinical treatment of HER2+ breast cancer with improved patients’ survival.
Highly Chiral Light Emission Using Plasmonic Helicoid Nanoparticles
Authors: Ahn Hyo‐Yong , Le Khai Q. , Narushima Tetsuya , Yamanishi Junsuke , Kim Ryeong Myeong , Nam Ki Tae , Okamoto Hiromi 
Published: May 2024

AbstractMaterials generating circularly polarized luminescence (CPL) have received increasing interest due to their potential applications in bioimaging, sensing, anticounterfeiting, and display technologies. The possibility of efficient CPL generation is explored for organic molecules, inorganic materials, and their hybrid systems. A chiral plasmonic nanostructure is one candidate for generating strong and highly dissymmetric CPL by coupling with the surrounding luminescent material. Here, the inherent luminescence of gold nanoparticles can produce CPL without using any secondary material is suggested. In this study, the generation of circularly polarized two‐photon‐induced photoluminescence (TPI‐PL) from chiral gold nanostructures is demonstrated. Measurements of TPI‐PL show that it has a strong dissymmetry factor of ≈0.7 for a single chiral Au nanoparticle. A theoretical simulation study showed that a local chiral electromagnetic field confined to the chiral gap structures contributes to the high degree of circular polarization in TPI‐PL. It is believed that this work provides a new route for novel CPL‐generating materials with strong dissymmetry and holds promise for various applications using CPL technology.
Unveiling the nanoscale architectures and dynamics of protein assembly with in situ atomic force microscopy
Authors: Zhai Zhaoyi , Schmid Sakshi Yadav , Lin Zhixing , Zhang Shuai , Jiao Fang 
Published: May 2024

AbstractProteins play a vital role in different biological processes by forming complexes through precise folding with exclusive inter‐ and intra‐molecular interactions. Understanding the structural and regulatory mechanisms underlying protein complex formation provides insights into biophysical processes. Furthermore, the principle of protein assembly gives guidelines for new biomimetic materials with potential applications in medicine, energy, and nanotechnology. Atomic force microscopy (AFM) is a powerful tool for investigating protein assembly and interactions across spatial scales (single molecules to cells) and temporal scales (milliseconds to days). It has significantly contributed to understanding nanoscale architectures, inter‐ and intra‐molecular interactions, and regulatory elements that determine protein structures, assemblies, and functions. This review describes recent advancements in elucidating protein assemblies with in situ AFM. We discuss the structures, diffusions, interactions, and assembly dynamics of proteins captured by conventional and high‐speed AFM in near‐native environments and recent AFM developments in the multimodal high‐resolution imaging, bimodal imaging, live cell imaging, and machine‐learning‐enhanced data analysis. These approaches show the significance of broadening the horizons of AFM and enable unprecedented explorations of protein assembly for biomaterial design and biomedical research.
Regulating Zn2+ Migration‐Diffusion Behavior by Spontaneous Cascade Optimization Strategy for Long‐Life and Low N/P Ratio Zinc Ion Batteries
Authors: Feng Jie , Li Xinyang , Ouyang Yuxin , Zhao Hongyang , Li Na , Xi Kai , Liang Junyan , Ding Shujiang 
Published: May 2024

AbstractParasitic side reactions and dendrite growth on zinc anodes are formidable issues causing limited lifetime of aqueous zinc ion batteries (ZIBs). Herein, a spontaneous cascade optimization strategy is first proposed to regulate Zn2+ migration‐diffusion behavior. Specifically, PAPE@Zn layer with separation‐reconstruction properties is constructed in situ on Zn anode. In this layer, well‐soluble poly(ethylene oxide) (PEO) can spontaneously separation to bulk electrolyte and weaken the preferential coordination between H2O and Zn2+ to achieve primary optimization. Meanwhile, poor‐soluble polymerized‐4‐acryloylmorpholine (PACMO) is reconstructed on Zn anode as hydrophobic flower‐like arrays with abundant zincophilic sites, further guiding the de‐solvation and homogeneous diffusion of Zn2+ to achieve the secondary optimization. Cascade optimization effectively regulates Zn2+ migration‐diffusion behavior, dendrite growth and side reactions of Zn anode are negligible, and the stability is significantly improved. Consequently, symmetrical cells exhibit stability over 4000 h (1 mA cm−2). PAPE@Zn//NH4+−V2O5 full cells with a high current density of 15 A g−1 maintains 72.2 % capacity retention for 12000 cycles. Even better, the full cell demonstrates excellent performance of cumulative capacity of 2.33 Ah cm−2 at ultra‐low negative/positive (N/P) ratio of 0.6 and a high mass‐loading (~17 mg cm−2). The spontaneous cascade optimization strategy provides novel path to achieve high‐performance and practical ZIBs.
One‐Handed Covalent Helical Ladder Polymers: The Dawn of a Tailorable Class of Chiral Functional Materials
Authors: Preda Giovanni , Pasini Dario 
Published: May 2024

AbstractIn the last decades, chemists have developed methods to synthesize helical molecular architectures using a combination of covalent and non‐covalent interactions. Very recently, the new class of completely covalent, one‐handed helical ladder polymers has vigorously emerged. Such polymers can be rationally and programmably obtained through an approach guided by the principles of chirality‐assisted‐synthesis (CAS) and making use synergically of two disciplines that have so far rarely interacted: non‐planar chiral π‐conjugated synthons and ladder polymer chemistry. The precise programmability of the 3D structure and new mechanical and chiroptical properties will lead to potential applications in areas such as enantiorecognition, catalysis, spintronics and chiral‐related optoelectronics. This minireview examines the emerging field of one‐handed helical ladder polymers, analyzing their synthesis, applications, and limitations.
Development of thermoplastic starch/poly(butylene adipate‐co‐terephthalate) biobased active packaging films and potential usage in the food industry
Authors: Tekin İdil , Ersus Seda 
Published: May 2024

AbstractThis study focused on the development and optimization of thermoplastic starch (TPS) and poly(butylene adipate‐co‐terephthalate) (PBAT) biobased active packaging films by incorporation with grape seed oil, alpha‐tocopherol, and rice husk. In the compound and film production step during extrusion for biobased active packaging film two variables, the antioxidant substance concentration (Grape seed oil, 0.5–4%; alpha‐tocopherol, 0.5–4%; rice husk, 1–5%), TPS concentration (60–90%) were optimized through response surface methodology (RSM) for highest tensile strength (MPa) and antioxidant activity (%) as responses. Among the resulting films, samples containing grape seed oil in particular exhibited an optimal balance, showcasing robust mechanical properties alongside potent antioxidant characteristics. Comprehensive analyses encompassing thickness, density, color, opacity, FTIR spectroscopy, total phenolic content, and energy consumption were conducted to assess the films' viability for potential deployment within the food industry. Based on the findings, it was determined that these biobased active packaging films made of TPS/PBAT held promise in safeguarding food products.
Polyethylene separator‐supported nanofiltration membranes for desalination
Authors: Liu Tianyu , Chen Dandan , Gao Feng , Song Yuchen , Zheng Zhuo , Kang Jian , Xu Ruizhang , Zhang Xiaojun , Zhang Yue , Xie Zhihui , Xiang Ming 
Published: May 2024

AbstractPolyethylene‐supported nanofiltration (NF) membranes have been reported for several cases in recent years. However, few have disclosed a NF membrane which achieves a high salt/water separation efficiency. Here, a novel polyamide NF membrane was prepared by conducting interfacial polymerization on poly(vinyl alcohol)‐decorated polyethylene separator. The polyethylene‐supported NF membranes were systematically investigated with respect to chemical structures, microscopic morphology, surface properties, as well as desalination performance. In particular, a distinctive morphology transformation occurred on the polyamide layers through regulating poly(vinyl alcohol) loading amounts. Performance testings demonstrated the optimal membrane reaches a water permeance over 17.4 L·m−2·h−1·bar−1 and Na2SO4 rejection above 98.7%, as well as favorable performance stability. This work may provide some consideration for fabricating NF membranes with new support layers and good desalination performance.
Systemic versus local patterns of limb joint articular morphology inferred from relative distances from morphological centroid
Authors: Horbaly Haley , Hubbe Mark 
Published: May 2024

AbstractJoint morphogenesis is a complex process known to require the interaction of developmental cascades and mechanical loading, yet many details of this interaction are incompletely understood. While prior work has established populational patterns of joint morphological (co)variance, exploring how these patterns manifest within the individual provides information on the deployment of morphogenic processes as either systemic or local influences on joint shape. To better identify the patterns of variance‐generating morphogenic processes, this study investigates the degree to which individual joint shapes deviate from population averages systematically across the body. Using three‐dimensional landmark data from 200 adult skeletons, we ranked individuals based on their distances from morphological centroids for eight major joints. Spearman correlations assessed associations between ranks across various articular pairings, testing hypotheses regarding systemic versus localized variance. Results reveal low coordination between deviations observed in conarticular surfaces, functional analogs, and same‐bone surfaces; however strong associations exist between antimeres, suggesting the left–right deployment of variance‐generating morphogenic patterns is highly consistent. These results support a model of localized rather than systemic processes driving variation in joint shape. While more remains to be elucidated about the specifics of articular surface morphogenesis, these findings advance our understanding of the systems of variance generation at play during development and growth of our definitive joint morphology.
Identification and validation of the TRHDE‐AS1/hsa‐miR‐449a/ADAMTS5 axis as a novel prognostic biomarker in prostate cancer
Authors: Lian Xin , Zhou Honglan , Liu Si 
Published: May 2024

AbstractDespite advancements in cancer research, the prognostic implications of competing endogenous RNA (ceRNA) networks in prostate cancer (PCa) remain incompletely understood. This study aimed to elucidate the prognostic relevance of ceRNA networks in PCa, utilizing a comprehensive bioinformatics approach alongside experimental validation. After searching The Cancer Genome Atlas (TCGA) database, RNA sequencing (RNA‐Seq) data were extracted to identify differentially expressed RNAs (DERs) between 491 PCa samples and 51 normal prostate tissues, following which a comprehensive bioinformatics strategy was implemented to construct a ceRNA network. An optimal prognostic signature comprising these DERs was then established and validated using TCGA data. In addition, functional validation was performed through RNA pull‐down, dual‐luciferase reporter assays, quantitative real‐time PCR, and western blot analysis conducted in PC‐3 and DU145 cell lines, thereby complementing the bioinformatics analysis. A total of 613 DERs, comprising 103 long noncoding RNAs (lncRNAs), 60 microRNAs (miRNAs), and 450 messenger RNAs (mRNAs), were identified and utilized in constructing a ceRNA network, which encompassed 23 lncRNAs, 9 miRNAs, and 52 mRNAs. An optimal prognostic signature was established, including VPS9D1 antisense RNA 1 (VPS9D1‐AS1), miR‐449a, cyclin‐dependent kinase 5 regulatory subunit 1 (CDK5R1), targeting protein for Xklp2 (TPX2), solute carrier family 7 member 11 (SLC7A11), copine7 (CPNE7), and maternal embryonic leucine zipper kinase (MELK), yielding area under the curve (AUC) values exceeding 0.8 across training, validation, and entire datasets. Our experiments results revealed an interaction between lncRNA TRHDE antisense RNA 1 (TRHDE‐AS1) and miR‐449a and that miR‐449a could target the ADAM metallopeptidase with thrombospondin type 1 motif 5 (ADAMTS5) mRNA. Knockdown of miR‐449a significantly impeded cell proliferation, G1/S transition, migration and invasion, and promoted apoptosis in PC‐3 and DU145 cells. Furthermore, knockdown of miR‐449a notably downregulated protein expression of CDK4, cyclin D1, N‐cadherin and vimentin, while upregulating protein expression of cleaved caspase‐3 and E‐cadherin. This study contributes to a deeper understanding of the prognostic‐linked ceRNA network in PCa, providing fundamental insights that could improve diagnostic and therapeutic approaches for PCa management.
Addressing transition conflict of green manufacturing to sustainable manufacturing: A drivers‐based modeling strategy for improving business performance: An Indian experience
Authors: Rehman Minhaj Ahemad , Seth Dinesh 
Published: May 2024

AbstractGreen manufacturing (GM) and sustainable manufacturing (SM) have become vital to counter environmental challenges. Industry, academia, and policymakers have been actively working to reduce the adverse environmental impacts of manufacturing. Though, used interchangeably, GM and SM are not the same but are related to each other. This fuels confusion and leads to conflict, as the transition simplifies similarities and differences between the two, in terms of their ‘drivers and relationships’ remain blurred and are never discussed. GM‐SM transition is never straightforward. It necessitates a shift in organizational priorities, practices, strategies, and goals and attracts researchers' attention. The study is significant as existing literature lacks the address of drivers‐based linkages between the two, and its management in the context of India, known for manufacturing capabilities and greenhouse gas‐based emissions. The study investigates GM‐SM relationships, attempts modeling, and establishes that if the transition is handled correctly, it leads to improved business performance and positive environmental impact. The findings guide what and where to focus to highlight priorities, making use of 14 and 22 drivers of GM and SM, respectively. It emphasizes the importance of implementing stringent environmental regulations, maintaining pressures from the Government, markets, and supply chain stakeholders along with management commitment with a clear vision. Authors expect that application experience will be useful for practitioners and researchers, in strengthening the linkages between environmental and manufacturing research domains.
Sustainable development in turbulent environments: The impact of ESG capabilities on responses to turbulence
Authors: Niesten Eva , Jolink Albert , Bacha Eliane 
Published: May 2024

AbstractFirms are increasingly operating in turbulent environments in which unpredictable change is driven by causes such as climate change and economic crises. In this paper, we study how firms perceive environmental turbulence and respond with four types of actions. We distinguish between actions creating economic value for the firm and actions creating sustainable value for society and the environment and between substantive and symbolic actions with only the former changing firms' strategies, structures, and processes. We built a unique dataset on large European firms and their 470 responses to turbulence from 2017 until 2022. We show that in volatile and complex environments, in which rapid change occurs but information is available, firms respond with substantive actions. In uncertain and ambiguous environments that lack information, firms respond with symbolic actions. These findings hold for responses that aim to create both economic and sustainable value. However, these findings change when firms acquire environmental, social, and governance (ESG) capabilities. With high and improving ESG capabilities, firms are more likely to respond with sustainable substantive actions, even when they perceive their environments to be uncertain. We contribute to the literature on organizational capabilities and corporate environmental responsiveness by showing that firms with superior and improving ESG capabilities increase their substantive commitments to sustainable development and are less inclined to base their responses on their perception of turbulence.
Design of a lightweight and easy‐to‐wear hand glove with multi‐modal tactile perception for digital human
Authors: Pan Zhigeng , Ren Hongyi , Liu Chang , Chen Ming , Mukherjee Mithun , Yang Wenzhen 
Published: May 2024

AbstractWithin the field of human–computer interaction, data gloves play an essential role in establishing a connection between virtual and physical environments for the realization of digital human. To enhance the credibility of human‐virtual hand interactions, we aim to develop a system incorporating a data glove‐embedded technology. Our proposed system collects a wide range of information (temperature, bending, and pressure of fingers) that arise during natural interactions and afterwards reproduce them within the virtual environment. Furthermore, we implement a novel traversal polling technique to facilitate the streamlined aggregation of multi‐channel sensors. This mitigates the hardware complexity of the embedded system. The experimental results indicate that the data glove demonstrates a high degree of precision in acquiring real‐time hand interaction information, as well as effectively displaying hand posture in real‐time using Unity3D. The data glove's lightweight and compact design facilitates its versatile utilization in virtual reality interactions.