bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiologic Trends in Human Papillomavirus–Associated Sinonasal Squamous Cell Carcinoma
Authors: Amanian Ameen , Ishii Masaru , Fakhry Carole , London Nyall R. 
Published: June 2024

ImportanceSinonasal squamous cell carcinoma (SNSCC) is the most commonly encountered cancer within the sinonasal cavity. Ongoing research has sought to ascertain the potential role of human papillomavirus (HPV) in the pathogenesis of SNSCC.ObjectiveTo assess trends in HPV-associated and HPV-independent SNSCC over time, including assessment of clinical demographics, treatment patterns, and survival.Design, Setting, and ParticipantsThis cohort study used patient data from the National Cancer Institute’s Surveillance, Epidemiology, and End Results Program database between 1975 and 2018. Anatomic sites with a greater predilection for HPV positivity (ie, nasal cavity, ethmoid sinus) were used as a surrogate for HPV-associated SNSCC; meanwhile, patients with SNSCC in the other subsites were classified into the HPV-independent group. Data were analyzed from August 2022 to May 2023.Main Outcomes and MeasuresClinical demographics and mortality trends over time were described for the HPV-associated and HPV-independent groups and further stratified according to stage on presentation.ResultsThe study population consisted of 3752 patients with SNSCC (mean [SD] age at diagnosis, 65.7 [13.3] years; 2417 [64.4%] male), with 1983 (52.9%) having HPV-associated SNSCC and 1769 (47.1%) with HPV-independent SNSCC. Patients with HPV-associated subsites compared with patients with HPV-independent SNSCC were more likely to present with localized disease (838 [42.3%] vs 162 [9.2%]), whereas more patients in the HPV-independent group than HPV-associated group presented with regional disease (1018 [57.5%] vs 480 [24.2%]). Incidence-based mortality was stable over time within the HPV-associated group (0.32%) and, conversely, showed a significant decrease within the HPV-independent group (−2.29%). Patients with HPV-associated SNSCC had a higher 5-year overall survival when compared with the HPV-independent group (62% vs 35% [difference, 27 percentage points; 95% CI, 23-31 percentage points]). The better 5-year overall survival in the HPV-associated group vs HPV-independent group was present across all disease stages (localized: hazard ratio [HR], 2.67; 95% CI, 1.96-3.65; regional: HR, 1.53; 95% CI, 1.29-1.82; and distant: HR, 1.97; 95% CI, 1.52-2.55).Conclusions and RelevanceThis cohort study showed that the proportion of HPV-associated SNSCC rose over time associated with both a rise in the proportion of nasal cavity SNSCC and a decrease in HPV-independent maxillary sinus SNSCC. These data suggest that HPV-associated SNSCC has a distinct demographic and prognostic profile, given the improved survival seen in patients with HPV-associated SNSCC.
Design Principles of Quinone Redox Systems for Advanced Sulfide Solid‐State Organic Lithium Metal Batteries
Authors: Lin Xiaodong , Apostol Petru , Xu Hewei , Bakuru Vasudeva Rao , Guo Xiaolong , Chen Zehan , Rambabu Darsi , Pal Shubhadeep , Tie Da , Zhang Yan , Xie Xinlong , Kim Seung‐Gi , Li Yi , Li Zhao , Du Mengyuan , Yan Shanshan , Zhang Xiaozhe , Yuan Ruming , Zheng Mingsen , Gauthy Fernand , Finsy Vincent , Zou Jianxin , Gohy Jean‐François , Dong Quanfeng , Vlad Alexandru 
Published: June 2024

AbstractThe emergence of solid‐state battery technology presents a potential solution to the dissolution challenges of high‐capacity small molecule quinone redox systems. Nonetheless, the successful integration of argyrodite‐type Li6PS5Cl, the most promising solid‐state electrolyte system, and quinone redox systems remains elusive due to their inherent reactivity. Here, a library of quinone derivatives is selected as model electrode materials to ascertain the critical descriptors governing the (electro)chemical compatibility and subsequently the performances of Li6PS5Cl‐based solid‐state organic lithium metal batteries (LMBs). Compatibility is attained if the lowest unoccupied molecular orbital level of the quinone derivative is sufficiently higher than the highest occupied molecular orbital level of Li6PS5Cl. The energy difference is demonstrated to be critical in ensuring chemical compatibility during composite electrode preparation and enable high‐efficiency operation of solid‐state organic LMBs. Considering these findings, a general principle is proposed for the selection of quinone derivatives to be integrated with Li6PS5Cl, and two solid‐state organic LMBs, based on 2,5‐diamino‐1,4‐benzoquinone and 2,3,5,6‐tetraamino‐1,4‐benzoquinone, are successfully developed and tested for the first time. Validating critical factors for the design of organic battery electrode materials is expected to pave the way for advancing the development of high‐efficiency and long cycle life solid‐state organic batteries based on sulfides electrolytes.
Photopolymerization Approach to Advanced Polymer Composites: Integration of Surface‐Modified Nanofillers for Enhanced Properties
Authors: Peng Xiaotong , Zhang Jing , Xiao Pu 
Published: June 2024

AbstractThe incorporation of functionalized nanofillers into polymers via photopolymerization approach has gained significant attention in recent years due to the unique properties of the resulting composite materials. Surface modification of nanofillers plays a crucial role in their compatibility and polymerization behavior within the polymer matrix during photopolymerization. This review focuses on the recent developments in surface modification of various nanofillers, enabling their integration into polymer systems through photopolymerization. The review discusses the key aspects of surface modification of nanofillers, including the selection of suitable surface modifiers, such as photoinitiators and polymerizable groups, as well as the optimization of modification conditions to achieve desired surface properties. The influence of surface modification on the interfacial interactions between nanofillers and the polymer matrix is also explored, as it directly impacts the final properties of the nanocomposites. Furthermore, the review highlights the applications of nanocomposites prepared by photopolymerization, such as sensors, gas separation membranes, purification systems, optical devices, and biomedical materials. By providing a comprehensive overview of the surface modification strategies and their impact on the photopolymerization process and the resulting nanocomposite properties, this review aims to inspire new research directions and innovative ideas in the development of high‐performance polymer nanocomposites for diverse applications.
2D Graphene Oxide Films Expand Functionality of Photonic Chips
Authors: Wu Jiayang , Zhang Yuning , Hu Junkai , Yang Yunyi , Jin Di , Liu Wenbo , Huang Duan , Jia Baohua , Moss David J. 
Published: June 2024

AbstractOn‐chip integration of 2D materials with unique structures and properties endow integrated devices with new functionalities and improved performance. With high flexibility in ways to modify its properties and compatibility with integrated platforms, graphene oxide (GO) is an exceptionally attractive 2D material for hybrid integrated photonic chips. Here, by harnessing unique property changes induced by photothermal effects in 2D GO films, novel functionalities beyond the capability of photonic integrated circuits are demonstrated. These include all‐optical control and tuning, optical power limiting, and nonreciprocal light transmission. The 2D layered GO films are integrated onto photonic chips with precise control of their thickness and size. Benefitting from the broadband optical response of 2D GO films, all three functionalities feature a very wide operational optical bandwidth. By fitting the experimental results with theory, the changes in GO film properties induced by the photothermal effects are analyzed, revealing interesting insights about the physics of 2D GO films. These results highlight the versatility of 2D GO films in implementing new functions for integrated photonic devices for a wide range of applications.
g‐C3N4 Photocatalyzed Decarboxylative Oxidation of Carboxylic Acids and the Oxidation of Alkenes and Alkanes
Authors: Bishi Sangita , Sankar Lenka Bhabani , Kreitmeier Peter , Reiser Oliver , Sarkar Debayan 
Published: June 2024

AbstractThe decarboxylative oxygenation of readily available carboxylic acids as well as the oxidation of alkenes and alkanes has been accomplished through visible light using g‐C3N4 as a robust and recyclable catalyst. The scalable protocol furnishes an array of aldehydes and ketones under mild reaction conditions, requiring only molecular oxygen as an oxidant. Notably, no addition of stochiometric amounts of base is required, and furthermore, the reaction proceeds efficiently open to the air.
Palladium‐Catalyzed Aerobic γ‐C(sp3)−H Lactamization Using a NOx‐based Redox Mediator
Authors: Jia Kai , Tu Yang‐Yang , Low Kam‐Hung , Luo Jun , Jiang Chao 
Published: June 2024

AbstractHerein, we report a Pd‐catalyzed aerobic lactamization of unactivated γ‐C(sp3)−H bonds of aliphatic carboxylic acids and amino acids derivatives. The utilization of Pd(OAc)2 as a catalyst, along with catalytic AgNO2 as an electron transfer mediator, circumvents the need for stoichiometric oxidants and demonstrates significant practicality.
Twelve‐month outcomes following temperature‐controlled radiofrequency treatment of the septal swell body for nasal airway obstruction
Authors: Pritikin Jordan , Silvers Stacey , Rosenbloom Jeffrey , Davis Bryan , Signore Anthony Del , Sedaghat Ahmad R. , Tajudeen Bobby A. , Schmale Isaac , Chandra Rakesh 
Published: June 2024

AbstractBackgroundImproved nasal airway obstruction (NAO) symptoms were reported at 3 months following temperature‐controlled radiofrequency (TCRF) treatment of the septal swell body (SSB). This report provides results from assessments of the long‐term safety and efficacy of TCRF treatment of SSB hypertrophy to treat NAO through 12 months posttreatment.MethodsThis prospective, multicenter, long‐term, open‐label study was conducted in nine centers within the United States and included patients with severe/extreme NAO attributed to SSB hypertrophy. Outcome measures included assessments of Nasal Obstruction Symptom Evaluation Score (NOSE), Numeric Rating Scale (NRS) ease‐of‐breathing, patient satisfaction, and adverse events at 6 and 12 months.ResultsOf the 70 patients treated, 65 and 62 patients completed the 6‐ and 12‐month follow‐up assessments. Compared to baseline, there was a 67.5% decrease in adjusted mean NOSE scores at 6 months (mean change −49.6, 95% confidence interval [CI] −54.8 to −44.4; p < 0.001) and a 65.4% decrease at 12 months (mean change −48.1, 95% CI −53.7 to −42.5); p < 0.001), which is consistent with previously published 3‐month results. A 62.0% and 62.5% improvement compared to baseline was observed in the NRS ease‐of‐breathing score at 6 and 12 months, respectively (p < 0.001). No serious adverse were reported overall and no new device‐ or procedure‐related adverse events were reported in the interval between 3 and 12 months posttreatment.ConclusionTCRF treatment of SSB hypertrophy has a significant and durable effect on improving the symptoms of NAO and health‐related quality of life in patients with symptoms of nasal obstruction and congestion through 12 months postprocedure.
Non‐Covalent and Covalent Binding of New Mixed‐Valence Cage‐like Polyoxidovanadate Clusters to Lysozyme
Authors: Tito Gabriella , Ferraro Giarita , Pisanu Federico , Garribba Eugenio , Merlino Antonello 
Published: June 2024

AbstractThe high‐resolution X‐ray structures of the model protein lysozyme in the presence of the potential drug [VIVO(acetylacetonato)2] from crystals grown in 1.1 M NaCl, 0.1 M sodium acetate at pH 4.0 reveal the binding to the protein of different and unexpected mixed‐valence cage‐like polyoxidovanadates (POVs): [V15O36(OH2)]5−, which non‐covalently interacts with the lysozyme surface, [V15O33(OH2)]+ and [V20O51(OH2)]n− (this latter based on an unusual {V18O43} cage) which covalently bind the protein. EPR spectroscopy confirms the partial oxidation of VIV to VV and the formation of mixed‐valence species. The results indicate that the interaction with proteins can stabilize the structure of unexpected – both for dimension and architecture – POVs, not observed in aqueous solution.
Nutzung des Perfluornaphthalin‐Radikalkations als selektiver Deelektronierer zur Erzeugung einer Vielzahl stark oxidierender reaktiver Kationen
Authors: Sellin Malte , Willrett Julie , Röhner David , Heizmann Tim , Fischer Julia , Seiler Matthis , Holzmann Celia , Engesser Tobias A. , Radtke Valentin , Krossing Ingo 
Published: June 2024

AbstractEin selektives Deelektronierungsreagenz mit einem sehr hohen Potential von +2.00 V (Lösung)/+2.41 V (Festkörper) vs. Fc+/0 wurde entwickelt und angewendet, welches auf einem raumtemperaturstabilen Perfluornaphthalin(NaphthalinF)‐Radikalkationsalz basiert. Durch die Deelektronierung von kommerziellem NaphthalinF durch [NO]+[F{Al(ORF)3}2]− im Festkörper kann [NaphthalinF]+⋅[F{Al(ORF)3}2]− (ORF=OC(CF3)3) in Gramm‐Maßstäben erhalten werden. Durch eine Thermodynamikanalyse wurde das Festkörperpotential des [NO]+‐Edukts zu +2.34 V vs. Fc+/0 mit [F{Al(ORF)3}2]− als Gegenion ermittelt, welches sich von +1.14 V vs. Fc+/0 für das kleinere [SbF6]−‐Anion stark unterscheidet. In selektiven Reaktionen wurde die Selektivität von [NaphthalinF]+⋅ in der Deelektronierung einer Vielzahl von organ(ometall)ischen Molekülen und Elementen in Lösung demonstriert: So wurden die Molekülstrukturen der Acen‐Dikationen [Tetracen]2+ und [Pentacen]2+ erhalten und der Carbonylkomplex des Ferrocen‐Dikations [Fc(CO)]2+ spektroskopisch nachgewiesen, sowie das [P9]+‐Kation aus weißem Phosphor, lösungsmittelfreies Kupfer(I)‐Salz aus Kupfermetall und der dikationische Fe(IV)‐Scorpionatkomplex [Fe(sc)2]2+ hergestellt.
Understanding Ligand Effects on Bielectronic Transitions: Chemo‐ and Electroreduction of Rhodium Bis(Diphosphine) Complexes to Low Oxidation States
Authors: Kick Anne‐Christine , Weyhermüller Thomas , Hölscher Markus , Kaeffer Nicolas , Leitner Walter 
Published: June 2024

AbstractRhodium complexes in the −I and 0 oxidation states are of great potential interest in catalytic applications. In contrast to their rhodium +I congeners, however, the structural and electronic parameters governing their access and stability are far less understood. Herein, we investigate the two‐electron reduction of a parameterized series of bis(diphosphine) Rh complexes [Rh(dxpy)2]NTf2 (x=P‐substituent, y=alkanediyl bridging P atoms). Through (electro)reductions from the RhI parents, Rh−I d10‐complexes were obtained and characterized spectroscopically, including 103Rh NMR data. The reductive steps convolute with structural rearrangements from square planar to tetrahedral coordination. We found that the extent of these reorganisations defines whether the first E0(RhI/0) and second E0(Rh0/−I) reduction potentials are normally ordered, leading to monoelectronic stepwise transitions, or inverted, giving bielectronic events. Reductionist approaches based on Hammett parameters or the P−Rh‐P bite angles provide only partial correlations with the redox potentials. However, we identified the C−O stretch of analogue diphosphine complexes as an expedient computational parameter that enables these correlations through both electronic and geometric features, even in a predictive manner. Gaining control over two‐electron reduction behaviors through rationalized ligand effects has potential impact beyond Rh complexes, for molecular and enzymatic metal sites commonly exhibiting bielectronic transitions.
Cyberbullying victimization and perpetration: The influence on cyberostracism and youth anxiety
Authors: Wang Zhiyou , Cheng Lin , Xie Zhe , Jiang Chaoxin 
Published: June 2024

AbstractCyberbullying is considered a major threat to adolescent anxiety. In this study, we aim to explore the simultaneous effects of cyberbullying victimization and perpetration on youth anxiety. Building on the childhood adversity model and the vulnerability‐stress model, we test the model wherein cyberbullying exposure is linked with cyberostracism, which in turn is expected to be associated with an increase in anxiety. We collected data from 1115 Chinese youth aged 11–19 years based on the stratified random sampling method. Structure equation modelling was conducted in Amos 26.0 to examine the proposed theoretical model. The findings suggested that compared with cyberbullying perpetration, the experience of cyberbullying victimization led to a significantly higher risk of youth anxiety. Multiple mediation analyses revealed that the three dimensions of cyberostracism, namely cyber direct excluded, cyber indirect excluded and cyber ignored, mediated the association of cyberbullying victimization and perpetration with youth anxiety. These results indicate that cyberostracism could be a risk factor for youth anxiety, thus providing new direction regarding intervention programs to reduce anxiety symptoms in adolescents.
Comprehensive characterization of bioactive peptides in rice bran protein hydrolysates: A multi‐platform approach for metabolomic profiling, identification, and molecular docking analysis
Authors: Kumar Ajay , Singh Narpinder , Joshi Robin 
Published: June 2024

AbstractBackground and ObjectivesTo optimize the utilization of rice by‐products, the rice bran protein hydrolysate (RBPH) was subjected to a process of separation and purification using ultrafiltration and reversed‐phase high‐performance liquid chromatography (RP‐HPLC). Subsequently, the identification of peptide sequences was carried out using mass spectrometer hybrid quadrupole‐time‐of‐flight and nontargeted metabolomic profiling done using UHPLC‐QTOF‐IMS profiling to identify antioxidant and antihypertensive amino acids.FindingsThree novel bioactive peptides, namely, STCCK, FMKSK, and KICILVFTLTTC, were identified within RBPH through enzymatic digestion using alcalase, pepsin, and trypsin. These peptides showed significant antioxidant activity and angiotensin‐converting enzyme (ACE) inhibitory activity. Molecular docking analyses elucidated various interaction mechanisms between these peptides and the ACE receptor protein, including hydrogen bonding and hydrophobic interactions. This suggested that the peptides effectively suppress ACE by forming hydrogen bonds with the active pockets of human ACE with a high affinity.ConclusionIn summary, peptides derived from rice bran protein exhibited distinguished antihypertensive and antioxidant properties, underscoring their potential for valuable utilization in addressing utilization of rice by‐products.Significance and NoveltyThe study advances scientific knowledge and offers practical solutions for health improvement and sustainable agriculture.
Metastatic right atrial mass in the presence of atrial septal defect: A rare clinical coincidence
Authors: Arzhangzadeh Alireza , Amirghofran Ahmad Ali , Javid Roozbeh Narimani , Mohammadkarimi Vahid , Abtahi Firoozeh , Rafati Navaei Mohammad , Nozhat Salma , Salahi Sarvenaz , Shafiei Sasan , Khorshidi Soorena 
Published: June 2024

Key Clinical MessageThe key takeaway from this clinical scenario is to choose the most appropriate and reasonable treatment plan when dealing with a patient who has atrial septal defect (ASD) and concurrent atrial and mediastinal masses. In such cases, a heart‐oncology team should make the therapeutic decision.AbstractRight atrial masses are not pretty rare and might be a diagnostic challenge. Thrombosis, tumors, and vegetations are primary differential diagnoses. Workup for these masses usually includes multimodality imaging and biopsy in selected cases. We report a case of a 37‐year‐old lady who presented with cough, dyspnea, and head and neck swelling after a cesarean section. Echocardiography revealed a right atrial mass accompanied by a secundum type atrial septal defect (ASD). Pulmonary CT Angiography was performed, in which a lobulated mass in the anterior mediastinum was detected, and a heart‐oncology team made the therapeutic decision. The patient was scheduled for surgical ASD closure and concomitant tissue biopsy. The pathology results were in favor of poorly differentiated germ cell tumors, and chemotherapy was started following the surgery. After two sessions of chemotherapy, the tumor did not respond to the primary regimen. Thus, an updated regimen was initiated. Compliance with the updated regimen was acceptable, and the patient is currently under treatment and follow‐up.
Actinomyces‐infected bronchopulmonary sequestration: An uncommon pathogen in a rare anomaly
Authors: Suliman Aasir M. , Alsayed Ahmed , Obiedat Sarah , Massad Ehab , Ul Haq Irfan 
Published: June 2024

Key Clinical MessageBronchopulmonary sequestration, a rare congenital anomaly, involves a nonfunctioning lung tissue mass supplied by anomalous vessels. It is rarely infected by Actinomyces, further complicating the clinical presentation, with limited reported cases. This case highlights the distinctive clinical aspects, diagnostic challenges, and successful management strategies of such a rare clinical entity.
On the fence: Combining multimodal imaging and laparoscopy for diagnosing tuberculous peritonitis
Authors: Yamada Kenji , Aoki Kazuaki , Tanaka Rina , Matsushima Seito , Sato Akiyuki , Kobayashi Takaaki , Moody Sandra , Nogi Masayuki 
Published: June 2024

Key Clinical MessageTuberculous peritonitis (TB peritonitis) is one of the most challenging forms of extrapulmonary TB to diagnose. While tumor markers can be elevated in patients with TB peritonitis, FDG‐PET/CT can aid in distinguishing TB peritonitis from malignancies, if an apron‐like omentum pattern is seen. Laparoscopy is crucial for accurate and early diagnosis.
Iron in Organometallic Transformations: A Sustainable Substitute for Noble Metals
Authors: Kumar Rohit , Tewari Tanuja , Chikkali Samir H. 
Published: June 2024

AbstractTransition metal catalysis plays a pivotal role in chemical synthesis. Noble metals often grab significant attention in organometallic catalysis due to their high reactivity. However, the serious issues associated with these metals such as low abundance, toxicity, geopolitical limitations, and volatile prices are driving the scientific community to discover sustainable alternatives. In this context, iron appears to be the first choice as an alternative metal due to its unique properties, including a range of stable oxidation states, Lewis acidity, high abundance in the earth‘s crust, and low toxicity. Over the past two decades, substantial progress has been made in iron catalysis. This overview examines the recent developments in iron‐catalyzed industrially relevant transformations such as hydroformylation, olefin isomerization, hydrosilylation, hydrophosphination, carbonylation, Wacker‐type oxidation, and plastic depolymerization. As witnessed throughout this review, the performance of iron can be significantly altered by suitable ligand selection and by tailoring the electronic and steric properties of the iron center. While noble metals remain the industry work‐horse, iron is inching closer and with extensive scientific understanding, it may replace noble metals in the near future.