bluuebunny/crossref_metadata_2025_split huggingface dataset:
Landscape evolution during Holocene transgression of a mid‐latitude low‐relief coastal plain: The southern North Sea
Authors: Eaton Stephen , Barlow Natasha L. M. , Hodgson David M. , Mellett Claire L. , Emery Andy R. 
Published: May 2024

AbstractLow‐relief coastal landscapes are at major risk of rising sea levels, as vertical changes in relative sea level have far‐reaching lateral effects. Integration of a dense 2D grid of seismic reflection data with sedimentological and geotechnical data obtained in two offshore wind farm zones allows detailed documentation of postglacial landforms and environmental change over a 1,021 km2 area in the western sector of the southern North Sea. Following the retreat of Last Glacial Maximum ice sheets from the southern North Sea, the resulting postglacial terrestrial landscape provided a surface for peatland formation as climate started to warm and the water table rose in response to relative sea‐level rise. Southward‐draining fluvial networks formed contemporaneously with the peatlands, and remnants of this terrestrial wetland landscape are buried beneath Holocene marine sediments. Distinctive isolated incisional features and discrete widening of fluvial channels that cut through the peats are interpreted as either tidal ponds or relict tidal channels. These features record the evolution of this landscape through the Early Holocene as marine transgression inundated a low‐relief coastal plain. The erosion of the peatlands observed in the cores, the patchy preservation of the organic wetland landscape, and the lack of preserved barrier systems recorded by the seismic reflection data suggest that the rate of relative sea‐level rise outpaced sediment supply during the Late Postglacial and Early Holocene in this area of the southern North Sea. In a regional context, the southward draining river channels contrast to northward fluvial drainage to the North Sea, pointing to a subtle drainage divide in the palaeolandscape and the presence of a low‐relief land bridge separating the North Sea and the English‐Channel/La Manche during the Early Holocene. The documented scenario of rising sea levels combined with decreasing sediment supply in a low‐relief setting is a situation faced by many global deltas and coastlines, which makes the southern North Sea a crucial archive of coastal landscape change.
Building a Validity Argument for the TOEFL Junior® Tests
Authors: Hsieh Ching‐Ni 
Published: May 2024

AbstractThe TOEFL Junior® tests are designed to evaluate young language students' English reading, listening, speaking, and writing skills in an English‐medium secondary instructional context. This paper articulates a validity argument constructed to support the use and interpretation of the TOEFL Junior test scores for the purpose of placement, progress monitoring, and evaluation of a test taker's English skills. The validity argument is built within an argument‐based approach to validation and consists of six validity inferences that provide a coherent narrative about the measurement quality and intended uses of the TOEFL Junior test scores. Each validity inference is underpinned by specific assumptions and corresponding evidential support. The claims and supporting evidence presented in the validity argument demonstrate how the TOEFL Junior research program takes a rigorous approach to supporting the uses of the tests. The compilation of validity evidence serves as a resource for score users and stakeholders, guiding them to make informed decisions regarding the use and interpretation of TOEFL Junior test scores within their educational contexts.
Effects of kefir consumption on gut microbiota and health outcomes in women with polycystic ovary syndrome
Authors: Çıtar Dazıroğlu Merve Esra , Acar Tek Nilüfer , Cevher Akdulum Münire Funda , Yılmaz Canan , Yalınay Ayşe Meltem 
Published: May 2024

AbstractPolycystic Ovary Syndrome (PCOS), which is common among women of reproductive age, is characterized by low‐grade chronic inflammation and is associated with several health problems and dysbiosis. Kefir has been shown to have many beneficial health effects; however, its effect on PCOS is unknown. This study aimed to examine the effect of kefir on the intestinal microbiota and health outcomes in PCOS. In this intervention study, 17 women with PCOS consumed 250 mL/day of kefir (containing Lactobacillus kefiranofaciens subsp. kefiranofaciens, Lactobacillus kefiranofaciens subsp. kefirgranum, Lactobacillus kefiri, Lactobacillus acidophilus, Lactobacillus parakefiri, Lactobacillus bulgaricus, Lactobacillus reuteri, Lactobacillus casei, Lactobacillus fermentum, Lactobacillus helveticus, Lactococcus lactis, Leuconostoc mesentereoides, Bifidobacterium bifidum, Streptococcus thermophilus, Kluyveromyces marxianus, Kluyveromyces lactis, Acetobacter pasteurianus, and Saccharomyces cerevisiae) for 8 weeks. Food consumption and physical activity records, anthropometrical measurements, quality of life, and fecal and blood samples were taken at the study's beginning and end. Quality of life in mental health (58.8 ± 15.08; 64.0 ± 15.23, respectively) and physical function (95.00 and 100.00, respectively) categories showed a significant increase after kefir intervention (p < .05). Additionally, Interleukin‐6 (IL‐6), one of the inflammatory cytokines, significantly decreased (174.00 and 109.10 ng/L, respectively) (p < .05). The intestinal barrier permeability was evaluated with zonulin, and no significant change was observed. Gut microbiota analysis showed that while the relative abundance of the class Bacilli and genus Lactococcus significantly increased, the genus Holdemania decreased with kefir consumption (p < .05). In conclusion, kefir appears to be beneficial for improving the microbiota and some health outcomes, like reducing inflammation and improving quality of life in PCOS. Therefore, kefir may be useful in the treatment of PCOS.
Autophagy‐induced cell death by aqueous and polyphenol‐enriched extracts of honeybush (Cyclopia spp.) in liver and colon cancer cells
Authors: Samodien Sedicka , de Kock Maryna , Joubert Elizabeth , de Beer Dalene , Kriel Jurgen , Gelderblom Wentzel C. A. , Lilly Mariska 
Published: May 2024

AbstractThe anti‐cancer potential of Cyclopia species (honeybush) has been demonstrated in several models. The present study investigated the effects of aqueous and polyphenol‐enriched (PE) extracts of C. subternata and C. genistoides, as well as mangiferin and hesperidin, on different cell growth parameters in human liver (HepG2) and colon (HT‐29) cancer cells. Mangiferin and hesperidin were most abundant in C. genistoides and C. subternata, respectively. Cyclopia subternata extracts had the highest ferric‐reducing antioxidant capacity. Following exposure of the cells to the extracts and compounds, cell viability, proliferation, and death (apoptosis and autophagy) were determined. Cyclopia subternata extracts reduced cell viability and inhibited cell proliferation the most, associated with depletion of ATP. In HepG2 cells, the PE extracts were less effective than the aqueous extracts in reducing cell viability but more effective in inhibiting cell proliferation. Despite disrupting cell growth, none of the extracts induced apoptosis. The aqueous extracts affected autophagy in both cancer cells. Disruption of mitochondrial membrane integrity by the different extracts, presumably via polyphenol/iron interactions, is postulated to be involved; however, mangiferin and hesperidin had no effect, suggesting that other polyphenols and/or complex interactions between compounds are likely responsible for the differential cytotoxic and/or cytoprotective effects of the extracts.
Grassland management intensity determines root development, soil structure, and their interrelationship: Results of a regional study of Leptosols in the Swabian Alps
Authors: Kuka Katrin , Joschko Monika 
Published: May 2024

AbstractBackgroundSoil structure is a key indicator of the functioning of soil processes in grasslands, which is influenced by site conditions and management.MethodsIn this study, we investigated soil structure and its relationship with root growth in 31 Leptosols under different grassland management intensities using X‐ray microcomputed tomography. A close relationship between land use intensity, soil structure, and root growth was observed.ResultsOur results show that land use type affects root development and soil structure. Pastures had more developed roots and more structured soils than meadows and mown pastures. However, all pastures were unfertilized, while meadows and mown pastures had both fertilized and unfertilized plots. Although no significant differences were found in the unfertilized plots, sample size was limited. In particular, fertilization negatively affected root growth and soil structure, resulting in significant differences between fertilized and unfertilized grasslands. Mowing frequency also had an effect on soil physics, but to a much lesser extent than fertilization.ConclusionsIncreased land use intensity, characterized by increased fertilization and more frequent mowing, reduces root growth and adversely affects soil structure. Therefore, X‐ray microcomputed tomography is a suitable method to investigate the relationship between soil structure and roots in the soil.
Trends of female authorship in head and neck surgery publications over the last decade
Authors: Ferraro Tatiana , Cole Jamie , Lee Sean M. , Pershad Alisha R. , Lee Esther , Hildebrand Hannah , Harrington Chloe , Derdzakyan Nicole A. , Gold Beck O. , Tummala Neelima , Thakkar Punam 
Published: May 2024

AbstractBackgroundWhile other otolaryngology subspecialties have established female authorship trends, there is no comprehensive study within head and neck surgery (HNS).MethodsFive researchers recorded the gender identity of first and senior authors from HNS subspecialty papers (head and neck oncology, endocrine surgery, salivary gland pathology, and microsurgery) derived from 10 journals in otolaryngology and oncology in the years 2013, 2016, 2019, and 2022.ResultsFrom 3457 articles, 6901 unique author identities were analyzed. Female authors represented 32% (N = 1103) of first authors and 20% (N = 690) of senior authors. Female authors were less likely to publish in microvascular and reconstructive surgery. Senior female authors were more likely to publish in higher impact journals than male senior authors, and first female authors had an increased likelihood of funding compared to their male counterparts.ConclusionsWhile female authors remain underrepresented in certain literature, we illustrate promising trends in productivity, funding allocation, and impact.
Immune‐monitoring of myelodysplastic neoplasms: Recommendations from the i4MDS consortium
Authors: Tentori Cristina A. , Zhao Lin P. , Tinterri Benedetta , Strange Kathryn E. , Zoldan Katharina , Dimopoulos Konstantinos , Feng Xingmin , Riva Elena , Lim Benjamin , Simoni Yannick , Murthy Vidhya , Hayes Madeline J. , Poloni Antonella , Padron Eric , Cardoso Bruno A. , Cross Michael , Winter Susann , Santaolalla Aida , Patel Bhavisha A. , Groarke Emma M. , Wiseman Daniel H. , Jones Katy , Jamieson Lauren , Manogaran Charles , Daver Naval , Gallur Laura , Ingram Wendy , Ferrell P. Brent , Sockel Katja , Dulphy Nicolas , Chapuis Nicolas , Kubasch Anne S. , Olsnes Astrid M. , Kulasekararaj Austin , De Lavellade Hugues , Kern Wolfgang , Van Hemelrijck Mieke , Bonnet Dominique , Westers Theresia M. , Freeman Sylvie , Oelschlaegel Uta , Valcarcel David , Raddi Marco G. , Grønbæk Kirsten , Fontenay Michaela , Loghavi Sanam , Santini Valeria , Almeida Antonio M. , Irish Jonathan M. , Sallman David A. , Young Neal S. , van de Loosdrecht Arjan A. , Adès Lionel , Della Porta Matteo G. , Cargo Catherine , Platzbecker Uwe , Kordasti Shahram ,   i4MDS consortium
Published: May 2024

AbstractAdvancements in comprehending myelodysplastic neoplasms (MDS) have unfolded significantly in recent years, elucidating a myriad of cellular and molecular underpinnings integral to disease progression. While molecular inclusions into prognostic models have substantively advanced risk stratification, recent revelations have emphasized the pivotal role of immune dysregulation within the bone marrow milieu during MDS evolution. Nonetheless, immunotherapy for MDS has not experienced breakthroughs seen in other malignancies, partly attributable to the absence of an immune classification that could stratify patients toward optimally targeted immunotherapeutic approaches. A pivotal obstacle to establishing “immune classes” among MDS patients is the absence of validated accepted immune panels suitable for routine application in clinical laboratories. In response, we formed International Integrative Innovative Immunology for MDS (i4MDS), a consortium of multidisciplinary experts, and created the following recommendations for standardized methodologies to monitor immune responses in MDS. A central goal of i4MDS is the development of an immune score that could be incorporated into current clinical risk stratification models. This position paper first consolidates current knowledge on MDS immunology. Subsequently, in collaboration with clinical and laboratory specialists, we introduce flow cytometry panels and cytokine assays, meticulously devised for clinical laboratories, aiming to monitor the immune status of MDS patients, evaluating both immune fitness and identifying potential immune “risk factors.” By amalgamating this immunological characterization data and molecular data, we aim to enhance patient stratification, identify predictive markers for treatment responsiveness, and accelerate the development of systems immunology tools and innovative immunotherapies.
Identifying key beliefs underlying QR code check‐in and compliance behaviours in the COVID‐19 pandemic
Authors: Mac Thi Nhung , Phipps Daniel J. , Parkinson Joy , Hamilton Kyra 
Published: May 2024

AbstractIssue AddressedThe implementation of quick response (QR) code check‐in compliance behaviour during the COVID‐19 pandemic featured in infection control strategies in several global jurisdictions, but was of particular interest in the Australian context, where it became mandated on a nationwide scale. We aimed to identify the salient beliefs people hold toward complying with the QR code check‐in using a Theory of Planned Behaviour belief‐based framework.MethodsAn elicitation study using open‐ended questions (Queensland; N = 93, Mage = 4.77 years, SD = 13.62 and Victoria; N = 76, Mage = 44.92 years, SD = 11.63) and a prospective correlational study using a two‐wave online survey (Queensland; N = 290, Mage = 38.99, 46.6% female and Victoria; N = 290, Mage = 38.27, 53.4% female) were conducted.ResultsQualitative data were coded through an iterative content analysis, while quantitative data were analysed using linear multiple regression. Behavioural, normative and control beliefs were associated with intention and behaviour in both samples. Variation in beliefs across the states also were observed.ConclusionsAcross both samples, beliefs in positive outcomes consistently exhibited stronger associations with both intention and behaviour than the reported negative outcomes. Distinct differences emerged between the two samples in terms of regression effects.So What?Results indicate individual experience may affect the beliefs which guide behaviour, supporting the potential efficacy of health promotion campaigns tapping into context specific beliefs and experiences if QR code check‐in is to be implemented as an infection control measure in future.
Is food and drink advertising across various settings associated with dietary behaviours and intake among Australian adolescents? Findings from a national cross‐sectional survey
Authors: Gascoyne Claudia , Scully Maree , Morley Belinda 
Published: May 2024

AbstractIssue AddressedThe pervasive promotion of energy‐dense, nutrient‐poor food and drinks undermines efforts by adolescents and their parent/carers to maintain a nutritious diet during a crucial developmental period. This study examined the association between awareness of food and drink advertisements and adolescents' dietary behaviours and intake.MethodsA sample of Australian secondary students aged 12–17 years (N = 8763) self‐reported their awareness of food and drink advertisements across seven settings, whether they had tried a new product or asked a parent/carer to purchase a product they had seen advertised, and their consumption of various unhealthy food and drink types. Analyses used multilevel mixed‐effects generalised linear models adjusted for school‐level clustering, socio‐demographic factors and television viewing.ResultsStudents with higher advertising awareness were more likely to have tried a new product they had seen advertised (adjusted prevalence ratio [APR] = 1.62, 95% CI = 1.51–1.73, p < .001) and asked their parent/carer to buy an advertised product (APR = 1.62, 95% CI = 1.51–1.73, p < .001) at least once in the past month. As advertising awareness increased, so too did students' likelihood of reporting these dietary behaviours. A high unhealthy food intake was more commonly reported among students with higher advertising awareness (APR = 1.45, 95% CI = 1.32–1.58, p < .001), as was a high unhealthy drink intake (APR = 1.29, 95% CI = 1.18–1.42, p < .001).ConclusionsAustralian adolescents are vulnerable to the persuasive effects of food and drink marketing.So What?Greater restrictions on the way the food and drink industry can market their products to adolescents are needed to better support them in developing and maintaining positive dietary behaviours.
The changes in biethnic acceptance across daily settings and biethnic adolescents' psychological well‐being during middle school transition
Authors: Hong Sung Hee , Lee Jiyeon , Chung Grace H. 
Published: May 2024

AbstractIntroductionPatterns of biethnic adolescents' perceived biethnic acceptance across families, peers, and school contexts were examined during the transition from elementary to middle school in South Korea. We also examined how the transition patterns were related to their psychological outcomes during this period.MethodsUtilizing 2‐wave data (2017 and 2019) from the Panel Survey of Korean Multicultural Youth Adjustment, a latent transition analysis was conducted. Participants were biethnic adolescents who were in 5th or 6th grade at Wave 1 (N = 245; 51.02% female; Mage = 11.38). Their fathers were Korean, and mothers were immigrants from neighboring countries. Familial ethnic socialization, peer discrimination, and school multicultural climate scores were used as indicators of biethnic acceptance. Outcomes of self‐esteem, depression, and biethnic affirmation were also examined.ResultsLatent profile and transition analyses yielded two groups (i.e., high acceptance and low acceptance) at each wave and four transition patterns (i.e., high‐high, low‐high, low‐low, and high‐low). Compared to high‐high group, which was the most prevalent group, low‐low and high‐low groups reported lower self‐esteem and ethnic affirmation, and greater depression at Wave 3.ConclusionsWhile for the majority of participants, their daily settings continued to be high in biethnic acceptance across the transition period, most at risk were those who perceived a decrease in biethnic acceptance in their daily settings. Results shed light on the need for support to maintain the context of high biethnic acceptance surrounding biethnic adolescents for their psychological well‐being in school transitions.
The marijuana, cannabinoids, and female reproductive system
Authors: Najafi Leila , Moasses Zia , Bahmanpour Soghra 
Published: May 2024

AbstractThe marijuana is considered as widely used recreational illicit drug that has become popular among women of reproductive age. It is believed that the marijuana use may have negative impacts on the female fertility. However, the exact mechanisms of its reproductive toxicity remain unclear. The studies suggest that the exogenous cannabinoids may interfere with endocannabinoid system and disrupt hypothalamic‐pituitary‐ovary axis. Consequently, it impacts the female fertility by disruption of normal secretion of ovarian sex hormones and menstrual cycles. However, other studies have shown that medical marijuana is useful analgesic agent for pain management. But, given that the wide range of cannabinoids side effects are reported, it seems that caution should be taken in the recreational use of these substances. In summary, this article aimed to review the possible impacts of marijuana and its derivatives on the main female reproductive organs and embryonic growth and development.
Comparing fabrication techniques for engineered cardiac tissue
Authors: Hatano Rachel , Smith Ariell M. , Raman Ritu , Zamora Jose E. , Bashir Rashid , McCloskey Kara E. 
Published: May 2024

AbstractTissue engineering can provide in vitro models for drug testing, disease modeling, and perhaps someday, tissue/organ replacements. For building 3D heart tissue, the alignment of cardiac cells or cardiomyocytes (CMs) is important in generating a synchronously contracting tissue. To that end, researchers have generated several fabrication methods for building heart tissue, but direct comparisons of pros and cons using the same cell source is lacking. Here, we derived cardiomyocytes (CMs) from human induced pluripotent stem cells (hiPSCs) and compare the assembly of these cells using three fabrication methods: cardiospheres, muscle rings, and muscle strips. All three protocols successfully generated compacted tissue comprised of hiPSC‐derived CMs stable for at least 2 weeks. The percentage of aligned cells was greatest in the muscle strip (55%) and the muscle ring (50%) compared with the relatively unaligned cardiospheres (35%). The iPSC‐derived CMs within the muscle strip also exhibited the greatest elongation, with elongation factor at 2.0 compared with 1.5 for the muscle ring and 1.2 for the cardiospheres. This is the first direct comparison of various fabrication techniques using the same cell source.