bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic valuation bias explains social influence on cheating behavior
Authors: Benistant Julien , Guigon Valentin , Nicolas Alain , Derrington Edmund , Dreher Jean-Claude 
Published: May 2024

AbstractObserving immoral behavior increases one’s dishonesty by social influence and learning processes. The neurocomputational mechanisms underlying such moral contagion remain unclear. We tested different mechanistic hypotheses to account for moral contagion. We used model-based fMRI and a new cheating game in which participants were sequentially placed in honest and dishonest social norm contexts. Participants’ cheating behavior increased in the dishonest norm context but was unchanged in the honest. The best model to account for behavior indicated that participants’ valuation was dynamically biased by learning that others had cheated. At the time of choice, the internalization of social norms was implemented in the lateral prefrontal cortex and biased valuations of cheating. During learning, simulation of others’ cheating behavior was encoded in the posterior superior temporal sulcus. Together, these findings provide a mechanistic understanding of how learning about others’ dishonesty biases individuals’ valuation of cheating but does not alter one’s established preferences.Significance statementSocial influence is at the root of human behavior. For example, we tend to follow others’ bad moral behavior such as cheating. Here, we explore the neuro-computational mechanisms of social influence on cheating behavior. We validated a new model capturing both how we learn about others’ (dis)honesty and how this bias our choice. We show that if we observe dishonest others we tend to be more dishonest ourselves. This behavioral change is driven by a bias dynamically changing with our knowledge about the others’ cheating behavior. Neurally, we found that the lateral prefrontal cortex implements this bias into the decision process while the posterior superior temporal sulcus and the temporo-parietal junction encode our learned representation of others’ cheating.
CysteineS-acetylation is a post-translational modification involved in metabolic regulation
Authors: Keenan E. Keith , Bareja Akshay , Lam Yannie , Grimsrud Paul A. , Hirschey Matthew D. 
Published: May 2024

ABSTRACTCysteine is a reactive amino acid central to the catalytic activities of many enzymes. It is also a common target of post-translational modifications (PTMs), such as palmitoylation. This long-chain acyl PTM can modify cysteine residues and induce changes in protein subcellular localization. We hypothesized that cysteine could also be modified by short-chain acyl groups, such as cysteineS-acetylation. To test this, we developed sample preparation and non-targeted mass spectrometry protocols to analyze the mouse liver proteome for cysteine acetylation. Our findings revealed hundreds of sites of cysteine acetylation across multiple tissue types, revealing a previously uncharacterized cysteine acetylome. Cysteine acetylation shows a marked cytoplasmic subcellular localization signature, with tissue-specific acetylome patterns and specific changes upon metabolic stress. This study uncovers a novel aspect of cysteine biochemistry, highlighting short-chain modifications alongside known long-chain acyl PTMs. These findings enrich our understanding of the landscape of acyl modifications and suggest new research directions in enzyme activity regulation and cellular signaling in metabolism.
Leukocytes have a heparan sulfate glycocalyx that regulates recruitment during inflammation
Authors: Priestley Megan J. , Hains Anna K. , Mulholland Iashia Z. , Spijkers-Shaw Sam , Zubkova Olga V. , Saunders Amy E. , Dyer Douglas P. 
Published: May 2024

AbstractThe glycocalyx is a proteoglycan-rich layer present on the surface of all mammalian cells that is particularly prevalent on endothelial cells lining the vasculature. It has been hypothesized that the glycocalyx mediates leukocyte migration by masking adhesion molecules and reducing leukocyte adhesion to the endothelium. Leukocyte recruitment is a key driver of inflammatory diseases, including the chronic skin disease, psoriasis. Here, we show that leukocytes express heparan sulfate, an important glycocalyx component, on their cell surface which is lost in response to psoriasis-like skin inflammation, whilst endothelial heparan sulfate expression is not affected. Treatment with a heparan sulfate mimetic during psoriasis-like skin inflammation protected heparan sulfate from cleavage by heparanase and resulted in reduced leukocyte accumulation in skin, yet unexpectedly, led to increased clinical signs of inflammation due to reduced Treg numbers. These findings reshape our understanding of immune cell recruitment by revealing the presence and function of a heparan sulfate glycocalyx on immune cells and highlight the complex effects of heparanase inhibitors on the immune response in this context.One Sentence SummaryLeukocytes express a glycocalyx on their surface which is shed in response to psoriasis-like skin inflammation, facilitating their migration into the skin.
G-Quadruplex Mediated c-myc Specific Downregulation: A Unique Pathway of the Anticancer Action of Immunomodulator Drugs
Authors: Sarkar Sunipa , Chatterjee Akash , Paul Subhojit , Bisoi Asim , Sen Prosenjit , Singh Prashant Chandra 
Published: May 2024

AbstractHydroxychloroquine (HCQ), and chloroquine (CQ) are in the preclinical trial stage for cancer along with their active application in autoimmune diseases and malaria. One of the critical hallmarks of cancer cells is the elevated expression of various oncogenes which promote cancer progression and contribute to poor prognosis. The upstream of the promoter region of these oncogenes often exhibits a G-quadruplex (G4) DNA structure which regulates the gene expression. Hence, targeting G4 structure has emerged as a promising therapeutic strategy for cancer. In this study, the recognition of HCQ and CQ with the G4 structure of different oncogenes and its effect on gene regulation has been explored by a combination of various biophysical andin-vitroandin-vivobiological methods. This study depicts that HCQ and CQ downregulate the c-myc oncogene transcription significantly in a G4-dependent manner compared to other oncogenes. The different biophysical techniques and molecular dynamics simulation studies illustrate that these drug molecules stack predominately at the terminal of the c-myc G4 and the binding of these molecules stabilizes c-myc G4 significantly higher than the G4 structure of other oncogenes. Thein-vitrocell data exhibit a notable reduction in both c-myc mRNA and protein levels in a triple-negative breast cancer cell line following HCQ treatment. The pre-clinical breast cancer mouse modelin-vivodata also indicate that HCQ reduces tumor growth through the downregulation of the c-myc oncogene. Simultaneously, HCQ also enhances the therapeutic efficacy of standard chemotherapeutic agents to be a potential candidate for combination therapy. This work demonstrates the alternative strategy of anticancer action of widely used drugs by specifically downregulating the c-myc oncogene in a G4-dependent manner.
Engineering the Mechanical Stability of a Therapeutic Affibody/PD-L1 Complex by Anchor Point Selection
Authors: Yang Byeongseon , Gomes Diego E. B. , Liu Zhaowei , Santos Mariana Sá , Li Jiajun , Bernardi Rafael C. , Nash Michael A. 
Published: May 2024

AbstractProtein-protein complexes can vary in mechanical stability depending on the direction from which force is applied. Here we investigated the anisotropic mechanical stability of a molecular complex between a therapeutic non-immunoglobulin scaffold called Affibody and the extracellular domain of the immune checkpoint protein PD-L1. We used a combination of single-molecule AFM force spectroscopy (AFM-SMFS) with bioorthogonal clickable peptide handles, shear stress bead adhesion assays, molecular modeling, and steered molecular dynamics (SMD) simulations to understand the pulling point dependency of mechanostability of the Affibody:(PD-L1) complex. We observed diverse mechanical responses depending on the anchor point. For example, pulling from residue #22 on Affibody generated an intermediate unfolding event attributed to partial unfolding of PD-L1, while pulling from Affibody’s N-terminus generated force-activated catch bond behavior. We found that pulling from residue #22 or #47 on Affibody generated the highest rupture forces, with the complex breaking at up to ∼ 190 pN under loading rates of ∼104-105pN/sec, representing a ∼4-fold increase in mechanostability as compared with low force N-terminal pulling. SMD simulations provided consistent tendencies in rupture forces, and through visualization of force propagation networks provided mechanistic insights. These results demonstrate how mechanostability of therapeutic protein-protein interfaces can be controlled by informed selection of anchor points within molecules, with implications for optimal bioconjugation strategies in drug delivery vehicles.
Heavy multiquark systems as clusters of smaller units: A diffusion Monte Carlo calculation
Authors: Gordillo M. C. , Segovia J. 
Published: May 2024

Multiquark systems appear less frequently than mesons and baryons despite the enormous worldwide experimental effort that has been made during the last two decades. In this work, we propose a possible explanation for that fact, restricting ourselves to the case of sets including only c and c¯ quarks. We show that those multiquarks can be thought as different combinations of smaller units that associate together to produce colorless assemblies with a definite value of the total spin. For instance, for the cccccc hexaquark with spin S=0, we have three possibilities; a set of six undistinguishable c quarks, an association of two ccc baryons, or a set of three cc diquarks close together. This means we can have three different values for the mass of an open-charm hexaquark with S=0. Using the diffusion Monte Carlo method, we calculate all possible combinations compatible with tetraquark ccc¯c¯, pentaquark ccccc¯, open-charm cccccc, and hidden-charm cccc¯c¯c¯ hexaquark structures with the minimum value of total spin (S=0 or S=1/2). We consider compact structures with radial wave functions including pair interactions between all the quarks in the cluster. We find that, in all cases, the mass of the multiquark decreases with the number of small units that conform the set of quarks. For instance, an open charm hexaquark made up of three diquarks has a smaller mass than a set of six c undistinguishable units. When the pieces that conform the multiquark are themselves colorless with a definite value of the total spin, the cluster splits into those smaller units that separate infinitely from each other.

Published by the American Physical Society
2024
Students we label international: an urgent call to reconceptualise research with international students
Authors: Merabet Ramzi 
Published: May 2024

PurposeThis article problematises the international student label by critically examining the mechanisms that actively portray international students as necessarily different, deficient and uncritical. It broadly aims to tackle the following issues: (a) to challenge the underpinnings of the international label; (b) to uncover the role of neo-essentialist representations of cohorts of students labelled international in sustaining financial exploitation and deficit narratives; and (c) to criticise the current hyper-internationalisation strategy widely adopted by UK HEIs.Design/methodology/approachThe paper mainly relies on findings from research that adopted narrative inquiry to explore the experiences of students labelled international. Data were collected via a series of interviews with 15 postgraduate students at a university in the north of England. The paper also makes use of brief statistical analyses to provide a general overview about the status of UK higher education (international student admission, net economic impact and income).FindingsThe paper reveals the underpinnings of the international label and how it is mobilised to other non-UK-domiciled students. The paper equally establishes a strong link between hyper-internationalisation and the (un)sustainability of the UK’s higher education sector.Research limitations/implicationsThe research is expected to raise important questions around the experiences and realities endured by students labelled international. In particular, the paper challenges the international label and the mechanisms that sustain the label at institutional levels.Practical implicationsThe paper calls for abandoning the international label as a marker of a presumed difference. Equally, the paper highlights the current unsustainability of the UK’s higher education sector and suggests a gradual cap on international tuition fees to alleviate some of the educational inequalities endured by students international, and to ensure the sustainability of the higher education sector.Originality/valueThis is the first research that openly challenges the international label and substitutes it by “students labelled international”. Equally, this is the first paper that recommends to cap international tuition fees on account of findings from students' narratives and statistics that reveal the unsustainability of the UK's higher education sector. Finally, the paper’s conceptual contribution includes a reference to the idea of hyper-internationalisation.
The role of health-related claims and situational skepticism on consumers’ food choices
Authors: Chaudhary Vartika , Sharma Dinesh , Nagpal Anish , Kalro Arti D. 
Published: May 2024

Purpose
This paper aims to examine the effect of three types of health-related claims (health, nutrition and ingredient) and product healthiness on situational skepticism toward the claims that appear on the front-of-package of food products. The effect of situational skepticism on the purchase intention of the product is further examined.

Design/methodology/approach
Two experimental studies were conducted with a 3 (health-related claims: health claim vs nutrition claim vs ingredient claim) × 2 (product healthiness: healthy vs unhealthy) between-subjects factorial design. Study 1 investigates the effects within a single product category (Biscuits) and Study 2 the effects across product categories (Salad and Pizza).

Findings
The results demonstrate that situational skepticism is the highest for health claims, followed by nutrition claims and the least for ingredient claims. In addition, situational skepticism is higher for claims appearing on unhealthy products vis-à-vis healthy ones. Finally, situational skepticism mediates the relationship between claim type, product healthiness and product purchase intention.

Research limitations/implications
This study contributes to the field of nutrition labeling by advancing research on information processing of nutrition labels through the lens of the persuasion knowledge model (Friestad and Wright, 1994). Specifically, this study contributes to a nuanced understanding of claim formats on how the language properties of the claim – its vagueness, specificity and verifiability – can affect consumer perception. This study finds that higher specificity, verifiability and lower vagueness of ingredient claims lead to lower skepticism and hence higher purchase intention.

Practical implications
Furthermore, this study incrementally contributes to the ongoing discussion about the claim–carrier combination by showing that health-related claims are better perceived on healthy compared to unhealthy products. Hence, managers should avoid health washing, as this can backfire and cause harm to the reputation of the firm.

Social implications
From a public policy point of view, this study makes a case for strong monitoring and regulations of ingredient claims, as consumers believe these claims easily and hence can be misled by false ingredient claims made by unethical marketers.

Originality/value
The scope of research on skepticism has largely been limited to examining a general individual tendency of being suspicious (i.e. dispositional skepticism) in health-related claims as well as other areas of marketing. In this research, the authors extend the scope by examining how specific types of claims (health vs nutrition vs ingredient) and product healthiness jointly impact consumer skepticism, i.e. situational skepticism.
Phase transition of multiple encapsulated PCMs in a U-shaped channel under MHD with ternary nanofluid
Authors: Selimefendigil Fatih , Oztop Hakan F. 
Published: May 2024

Purpose
Multiple encapsulated phase change materials (PCMs) are used in a wide range of applications, including convective drying, electronic cooling, waste heat recovery and air conditioning. Therefore, it is important to understand the performance of multiple PCMs in channels with flow separation and develop methods to increase their effectiveness. The aim of the study is to analyze the phase transition dynamics of multiple encapsulated PCMs mounted in a U-shaped tube under inclined magnetic field by using ternary nanofluid.

Design/methodology/approach
The PCMs used in the upper horizontal channel, vertical channel and lower horizontal channel are denoted by M1, M2 and M3. Magnetic field is uniform and inclined while finite element method is used as the solution technique. Triple encapsulated-PCM system study is carried out taking into account different values of Reynolds number (Re, ranges from 300 to 1,000), Hartmann number (Ha ranges from 0 and 60), magnetic field inclination (between 0 and 90) and solid volume fraction of ternary nanofluid (between 0 and 0.03). The dynamic response of the liquid fraction is estimated for each PCM with varying Re, Ha and t using an artificial neural network.

Findings
It is observed that for PCMs M2 and M3, the influence of Re on the phase transition is more effective. For M2 and M3, entire transition time (t-F) lowers by approximately 47% and 47.5% when Re is increased to its maximum value, whereas it only falls by 10% for M1. The dynamic characteristics of the phase transition are impacted by imposing MGF and varying its strength and inclination. When Ha is raised from Ha = 0 to Ha = 50, the t-F for PCM-M2 (PCM-M3) falls (increases) by around 30% (29%). For PCMs M1, M2 and M3, the phase transition process accelerates by around 20%, 30% and 28% when the solid volume fraction is increased to its maximum value.

Originality/value
Outcomes of this research is useful for understanding the phase change behavior of multiple PCMs in separated flow and using various methods such as nano-enhanced magnetic field to improve their effectiveness. Research outputs are beneficial for initial design and optimization of using multiple PCMs in diverse energy system technologies, including solar power, waste heat recovery, air conditioning, thermal management and drying.
Translanguaging on an English-medium undergraduate research methods course for Vietnamese psychology students learning in their second language: a practitioner enquiry
Authors: Davey Gareth 
Published: May 2024

PurposeTranslanguaging is a language-related pedagogy drawing upon all resources within a learner’s linguistic repertoire, in contrast to conventional monolingual pedagogy. Most research about translanguaging concerns English-language learning in primary schools and secondary schools and overlooks psychology subject matter, higher education and countries in southeast Asia. This article reports a small-scale practitioner enquiry into translanguaging on an English-medium undergraduate research methods course for psychology students in Vietnam and into the usefulness of the Multimodalities-Entextualization Cycle as a conceptual framework for integrating translanguaging into the course.Design/methodology/approachData were collected through semi-structured interviews with students and reflective journaling by the teacher, and the data were analysed in a hybrid deductive-inductive thematic analysis.FindingsThe first theme about teaching and translanguaging consists of the following subthemes: (a) enhanced communication, (b) increased awareness of language use, (c) supported interaction in class and (d) time and workload issues. The second theme about learning and translanguaging is subdivided into the following subthemes: (a) a new approach to learning, (b) beneficial for learning, (c) developing confidence in learning in English and (d) enjoyment of translanguaging. The conceptual framework underpinning the study was useful for designing and implementing translanguaging activities for the course.Research limitations/implicationsThe study is limited to one course and a small group of students in Vietnam learning English as a second language. It addresses limited research on translanguaging in psychology courses, higher education, and southeast Asia.Practical implicationsThe study makes a valuable contribution to the teaching profession by offering practical insights into the application, benefits, and drawbacks of translanguaging for psychology and research methods subject matter.Social implicationsMoreover, the findings lay the groundwork for potential influences on education policy, aligning with broader societal impacts.Originality/valueThe study makes a valuable contribution to the literature by delving into a relatively unexplored domain.
The monetary policy of the State Bank of Vietnam, households and income distribution: the evidence from DSGE model
Authors: Nguyen Trung Duc , Trieu Lanh Kim , Le Anh Hoang 
Published: May 2024

Purpose
This paper aims to propose a dynamic stochastic general equilibrium (DSGE) model for the State Bank of Vietnam (SBV) to assess the response from the household sector to monetary policy shocks through the consumption function. Moreover, the transmission from monetary policy to household consumption and income distribution is experimented with through the vector autoregression (VAR) model.

Design/methodology/approach
In this study, the authors used the maximum likelihood estimation to estimate the DSGE and VAR models with the sample from 1996Q1 to the end of 2021Q4 (104 observations).

Findings
The DSGE model’s results show that the response of the household sector is as expected in the theory: a monetary policy shock occurs that increases the policy interest rate by 0.29%, leading to a decrease in consumer spending of about 0.041%, the shock fades after one year. Estimates from the VAR model give similar results: a monetary policy shock narrows income inequality after about 2–3 quarters and this process tends to slow down in the long run.

Research limitations/implications
Based on the research results, the authors propose policy implications for the SBV to achieve the goal of price stability, and stabilizing the macro-economic environment in Vietnam.

Originality/value
The findings of the study have theoretical contributions and empirical scientific evidence showing the effectiveness of the implementation of the SBV’s monetary policy in the context of macro-instability, namely: flexibility, caution and coordination of different measures promptly.