bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of Allosteric Small Molecule APOBEC3B Inhibitors fromIn SilicoScreening
Authors: Jones Katherine F. M. , Demir Özlem , Wyllie Mackenzie K. , Grillo Michael J. , Morris Clare , Hirakis Sophia P. , Kardile Rahul Dadabhau , Walters Michael A. , Harris Reuben S. , Amaro Rommie E. , Harki Daniel A. 
Published: April 2024

AbstractAPOBEC3B cytosine deaminase contributes to the mutational burdens of tumors, resulting in tumor progression and therapy resistance. Small molecule APOBEC3B inhibitors have potential to slow or mitigate these detrimental outcomes. Through molecular dynamics (MD) simulations and computational solvent mapping analysis, we identified a novel putative allosteric pocket on the C-terminal domain of APOBEC3B (A3Bctd), and virtually screened the ChemBridge Diversity Set (N∼110,000) against both the active and potential allosteric sites. Selected high-scoring compounds were subsequently purchased, characterized for purity and composition, and tested in biochemical assays, which yielded 13 hit compounds. Orthogonal NMR assays verified binding to the target protein. Initial selectivity studies suggest these compounds preferentially target A3Bctd over related deaminase APOBEC3A (A3A), and MD simulations indicate this selectivity may be due to the steric repulsion from H56 that is unique to A3A. Taken together, our studies represent the first virtual screening effort against A3Bctd that has yielded candidate inhibitors suitable for further development.
DivergentC. eleganstoxin alleles are suppressed by distinct mechanisms
Authors: Zdraljevic Stefan , Walter-McNeill Laura , Bruni Giancarlo N. , Bloom Joshua S. , Leighton Daniel H.W. , Collins J.B. , Marquez Heriberto , Alexander Noah , Kruglyak Leonid 
Published: April 2024

AbstractToxin-antidote elements (TAs) are selfish DNA sequences that bias their transmission to the next generation. TAs typically consist of two linked genes: a toxin and an antidote. The toxin kills progeny that do not inherit the TA, while the antidote counteracts the toxin in progeny that inherit the TA. We previously discovered two TAs inC. elegansthat follow the canonical TA model of two linked genes:peel-1/zeel-1andsup-35/pha-1. Here, we report a new TA that exists in three distinct states across theC. eleganspopulation. The canonical TA, which is found in isolates from the Hawaiian islands, consists of two genes that encode a maternally deposited toxin (MLL-1) and a zygotically expressed antidote (SMLL-1). The toxin induces larval lethality in embryos that do not inherit the antidote gene. A second version of the TA has lost the toxin gene but retains a partially functional antidote. MostC. elegansisolates, including the standard laboratory strain N2, carry a highly divergent allele of the toxin that has retained its activity, but have lost the antidote through pseudogenization. We show that the N2 toxin allele has acquired mutations that enable piRNA binding to initiate MUT-16-dependent 22G small RNA amplification that targets the transcript for degradation. The N2 haplotype represents the first naturally occurring unlinked toxin-antidote system where the toxin is post-transcriptionally suppressed by endogenous small RNA pathways.
Phase coexistence and transitions between antiferromagnetic and ferromagnetic states in a synthetic antiferromagnet
Authors: Barker C. E. A. , Fallon K. , Barton C. , Haltz E. , Almeida T. P. , Villa S. , Kirkbride C. , Maccherozzi F. , Sarpi B. , Dhesi S. S. , McGrouther D. , McVitie S. , Moore T. A. , Kazakova O. , Marrows C. H. 
Published: April 2024

In synthetic antiferromagnets (SAFs), antiferromagnetic (AFM) order and synthesis using conventional sputtering techniques is combined to produce systems that are advantageous for spintronics applications. Here we present the preparation and study of SAF multilayers possessing both perpendicular magnetic anisotropy and the Dzyaloshinskii-Moriya interaction. The multilayers have an antiferromagnetically aligned ground state but can be forced into a full ferromagnetic (FM) alignment by applying an out-of-plane field ∼100 mT. We study the spin textures in these multilayers in their ground state as well as around the transition point between the AFM and FM states at fields ∼ 40 mT by imaging the spin textures using complementary methods: photoemission electron, magnetic force, and Lorentz transmission electron microscopies. The transformation into a FM state by field proceeds by a nucleation and growth process, where skyrmionic nuclei form and then broaden into regions containing a ferromagnetically aligned labyrinth pattern that eventually occupies the whole film. Remarkably, this process occurs without any significant change in the net magnetic moment of the multilayer. The mix of antiferromagnetically and ferromagnetically aligned regions on the micron scale in the middle of this transition is reminiscent of a first-order phase transition that exhibits phase coexistence. These results are important for guiding the design of spintronic devices whose operation is based on spin textures in perpendicularly magnetized SAFs.

Published by the American Physical Society
2024
Autoparametric Resonance Extending the Bit-Flip Time of a Cat Qubit up to 0.3 s
Authors: Marquet A. , Essig A. , Cohen J. , Cottet N. , Murani A. , Albertinale E. , Dupouy S. , Bienfait A. , Peronnin T. , Jezouin S. , Lescanne R. , Huard B. 
Published: April 2024

Cat qubits, for which logical |0⟩ and |1⟩ are coherent states |±α⟩ of a harmonic mode, offer a promising route towards quantum error correction. Using dissipation to our advantage so that photon pairs of the harmonic mode are exchanged with single photons of its environment, it is possible to stabilize the logical states and exponentially increase the bit-flip time of the cat qubit with the photon number |α|2. A large two-photon dissipation rate κ2 ensures fast qubit manipulation and short error-correction cycles, which are instrumental to correct the remaining phase-flip errors in a repetition code of cat qubits. Here, we introduce and operate an autoparametric superconducting circuit that couples a mode containing the cat qubit to a lossy mode whose frequency is set at twice that of the cat mode. This passive coupling does not require a parametric pump, and it reaches a rate κ2/2π≈2  MHz. With such a strong two-photon dissipation, bit-flip errors of the autoparametric cat qubit are prevented for a characteristic time up to 0.3 s with only a mild impact on phase-flip errors. In addition, we illustrate how the phase of a quantum superposition between |α⟩ and |−α⟩ can be arbitrarily changed by driving the harmonic mode while keeping the engineered dissipation active.

Published by the American Physical Society
2024
Qatar Airways–FC Barcelona sponsorship deal: a catalyst of sports diplomacy?
Authors: Aras Bülent , Özel Meltem 
Published: April 2024

PurposeThe purpose of this study is to evaluate how Qatar Airways’ sponsorship of FC Barcelona affects Qatar’s sports diplomacy and brand awareness. It focuses on the sponsorship’s demand strategy and takes into account the opinions and attitudes of Spanish nationals toward Qatar and Qatar Airways. Design/methodology/approach To assess this, a survey of 434 Spanish nationals from 17 different regions from four zones (North, South, Center, and East) in Spain between November 3, 2022 and November 21, 2022 was conducted using a strata sampling method. FindingsWe argue that Qatar Airways’ sponsorship of FC Barcelona serves to improve Qatar’s recognition and national reputation in Spain. We also found that there is a need for consistent sponsorship and marketing efforts in sports diplomacy to better fulfill public diplomacy aims. Overall, this paper concludes that Qatar Airways’ sponsorship of FC Barcelona positively contributes to the country’s sports diplomacy despite significant challenges.Originality/valueThe major contribution of this study to the literature is the discussion of the role of sports sponsorships in the recognition of the sponsor, which was assessed through conducting a quantitative analysis of public opinion in the sponsored team’s host country.
Excellence in healthcare: nurturing servant leadership, fostering collaborative culture and promoting social sustainability in the UAE – strategies for transformation
Authors: Upadhyay Divya 
Published: April 2024

Purpose
This study aims to investigate the healthcare sector of the United Arab Emirates (UAE) to explore the significance of servant leadership and collaborative culture in fostering social sustainability. The primary objective of this paper is to investigate how servant leadership and a collaborative culture contribute to social sustainability in health care in the UAE. With a focus on promoting well-being within healthcare organizations, the paper aims to uncover the synergies between servant leadership, collaborative culture, and social sustainability.

Design/methodology/approach
This paper conducted a multilayer literature review of existing literature on servant leadership, collaborative culture and social sustainability in health care, both globally and specifically in the UAE context, and a conceptual model was proposed.

Findings
Servant leadership proves to be a culturally pertinent and effective leadership model within the UAE due to its alignment with cultural values, emphasis on community support, and the robust health-care system that contributes to individual well-being. This combination establishes a solid foundation for fostering a healthy and sustainable society.

Research limitations/implications
Limitations and implications are discussed. The current research has not identified the boundary conditions under which servant leadership and collaborative culture may be more or less effective. This could involve exploring industry-specific influences or contextual factors. Theoretical and practical implications are discussed.

Originality/value
The research seeks to unravel the interconnections between servant leadership, collaborative culture and social sustainability. To the best of the author’s knowledge, none of the studies have explored the interrelationships of these constructs, particularly in the UAE context.
Gastronomic manifestation in the function of branding a tourist destination
Authors: Čavić Slobodan , Ćurčić Nikola , Radivojevic Nikola , Gardašević Živanov Jovana , Lakićević Marija 
Published: April 2024

PurposeThe paper examines the role and significance of gastronomic manifestations in the context of destination branding, within the framework of image transfer mechanisms and the Associative Network Memory Model.Design/methodology/approachThe research was conducted on a sample of 53 gastronomic events in the tourist destination of Vojvodina.FindingsThe results indicate that gastronomic manifestations image has a positive impact on the brand image and brand identity of the destination, as well as the destination's overall image. Furthermore, the study found that the food experience has a positive influence on the image of gastronomic events and the destination.Originality/valueThe study contributes to the advancement of research on tourist destination branding.
What motivates international tourists’ positive word-of-mouth? The effect of individualist and collectivist cultural orientations
Authors: Zhong Lina , Zhu Mengyao , Li Xiaonan , Morrison Alastair M. , Camilleri Mark Anthony 
Published: April 2024

Purpose
The purpose of this research paper was to determine which needs for incentives influence positive word-of-mouth (PWOM) among international tourists and how these needs differ based on the cultural orientation toward individualism and collectivism.

Design/methodology/approach
This research used online surveys to gather data from 959 Australian, US, UK, Japanese and Korean respondents who had visited Beijing. A random sampling method was used, and data were analyzed using SmartPLS 4.0. By adopting the existence relatedness growth theory, the findings explain how cultural orientation affects the impact of needs for incentives in generating PWOM.

Findings
Three hypothesized relationships were significant for Australia/UK/USA and Japan/Korea – the effect of needs for incentives on motivation, the effect of motivation on PWOM and the effects of needs for incentives on PWOM were significant and positive for Australia/UK/USA and Japan/Korea. The effect of needs for incentive type on motivation varied across national populations, and the intensity of the effects of needs for incentive type on PWOM was also different. For Australian, UK and the US tourists, the honorary title was the most influential need to stimulate word-of-mouth motivation. The need for cultural learning was the most influential for Japanese and Korean tourists.

Originality/value
This research contributes to the literature by exploring and comparing the needs for incentives that influence PWOM among tourists from the perspective of individualism and collectivism. The results also increase the understanding of the relationships among needs for incentives, motivation and PWOM.
Digital nomads in destination marketing
Authors: Ay Eşref , Güzel Melik Onur 
Published: April 2024

PurposeThe objective of this paper is to determine the impact of digital nomads on destination marketing.Design/methodology/approachThe article was designed using a six-layer research onion. The research design was developed with an interpretive paradigm using an inductive multi-qualitative approach.FindingsAccording to the results obtained, it was found that digital nomads play an important role in destination marketing and are effective in creating intentions to visit destinations.Originality/valueThe study reveals a methodologically different approach to the theme by analysing multi-qualitative data. The theoretical contribution of the article is that it shows that digital nomads' YouTube video posts regarding destinations are more effective on other digital nomads and those who want to become digital nomads.
Transurethral water vapour therapy (Rezūm) for catheter‐dependent men secondary to benign prostatic hyperplasia: A retrospective study in a Hong Kong population
Authors: Chow Henry , Ip Chi Ho , Lam Yiu Chung 
Published: April 2024

AbstractAimRezūm is a novel treatment for patients with moderate to severe lower urinary tract symptoms as a result of benign prostatic hyperplasia (BPH). Recently, it has expanded to patients with urinary retention causing catheter dependence and the results are promising in Whites. However, it is unclear how effective Rezūm is in the Chinese population. Here, we report our experience in performing Rezūm on catheter‐dependent Chinese men with BPH and evaluate its safety and efficacy.MethodsA retrospective review of catheter‐dependent patients with BPH who underwent Rezūm from January to August 2022 was conducted. We evaluated the success rate of trial without catheter (TWOC) and compared pre‐ and post‐operative (at 6 months) uroflowmetry results, International Prostate Symptoms Score (IPSS), IPSS Quality of Life Score (IPSS QoL), and prostate volume.ResultsSixty‐three patients had Rezūm performed (44 and 19 patients had refractory urinary retention and obstructive uropathy, respectively) with a mean age of 74 years and a mean prostate size of 53.9 mL. The first attempt at TWOC was successful in 53 patients (85.5%; range 15–44 days post‐operation). By 98 days after the operation, all patients could void spontaneously. The 6‐month follow‐up showed that IPSS and IPSS QoL scores decreased by a mean of 9.0 and 1.8 points, respectively (both P < .01). The mean pre‐operative post‐voided residual urine was reduced by 559 mL (P < .01), with a mean prostate size reduction of 9.4 mL (P < .01). Seven patients had non‐serious complications (Grade 1–2 Clavien–Dindo classification) within 30 days of operation.ConclusionRezūm was shown to be effective and safe in catheter‐dependent Chinese men with BPH.
Evaluation of contrast induced nephropathy related risk factors and long‐term results
Authors: Koyuncuoğlu Alper , Avşar Münevver Gül , Tarhan Ahmet , Oktay Muhammed Emin , Sağlam Selin , Koçak Gülay , Kılıçkesmez Kadriye 
Published: April 2024

AbstractIntroductionWe aimed to evaluate the frequency of contrast induced nephropathy (CIN), its relationship with accepted risk factors and long‐term renal outcomes in patients who underwent coronary angiography (CAG).MethodsAll patients who underwent CAG between April 2020 and April 2021 were retrospectively evaluated. CIN was defined as characteristic increase in serum creatinine after CAG.ResultsCIN developed in 50 (5.4%) of 934 patients. The CIN rate was found to be statistically significantly higher in patients with diabetes, hypertension, heart failure and those using diuretics. Pre‐procedural hemoglobin, albumin and GFR were found to be independent risk factors for CIN. After discharge, the urea and creatinine values of the patients who developed CIN were significantly higher than those who did not.ConclusionWe concluded that in order to reduce the development of CIN, hemoglobin and albumin levels should be evaluated with renal functions before the procedure and they should be kept within normal limits.
Advancing the decadal plan for the science of nutrition: Progressing a framework for implementation
Authors: Truby Helen , Allman‐Farinelli Margaret , Beck Eleanor J. , Beckett Emma L. , Bondonno Catherine , Dordevic Aimee L. , Livingstone Katherine M. , Willcox Jane , Wilkinson Shelley A. ,   the National Committee for Nutrition and its working groups
Published: April 2024

AbstractAimsIn 2019, the Australian Academy of Science in collaboration with the nutrition community published the decadal plan for the science of nutrition. This article aims to review progress towards each of its pillar goals (societal determinants, nutrition mechanisms, precision and personalised nutrition, and education and training) and two enabling platforms (a national data capability and a trusted voice for nutrition science), prioritise actions, and conceptualise program logic implementation models. This process also brought together public health nutrition researchers to reflect on societal determinants of health, and advise how the next 5 years of the decadal plan could reflect contemporary issues.MethodsTwo engagement events, in 2023, brought together experienced and mid‐ and early‐career nutrition professionals for co‐creation of implementation logic models.ResultsOne hundred and nine early and mid‐career professionals were involved. A revised model for the decadal plan pillars emerged from synthesis of all logic models. This new model integrated the precision and personalised nutrition pillar with nutrition mechanisms pillar. These combined pillars build towards the national data capability enabling platform and created new cross‐cutting themes for education and training. The need arose for greater focus on respectful engagement with Aboriginal and Torres Strait Islander communities and sustained effort to build cross‐disciplinary collaboration to realise the plan's societal determinants goals. A new alliance for nutrition science is proposed to become a unified advocacy voice and build trust in nutrition professionals.ConclusionsA programmatic approach provides a road map for implementing the decadal plan for the final 5 years.
The metabolic effects of habitual leg shaking: A randomized crossover trial
Authors: Bao Riqiang , Hu Yixiang , Xu Rui , Gao Chong , Guo Yuhan , Zhu Yashu , Pan Shijia , Wang Weiqing 
Published: April 2024

AbstractAimsThe adverse effects of sedentary behavior on obesity and chronic diseases are well established. However, the prevalence of sedentary behavior has increased, with only a minority of individuals meeting the recommended physical activity guidelines. This study aimed to investigate whether habitual leg shaking, a behavior traditionally considered unfavorable, could serve as an effective strategy to improve energy metabolism.Materials and MethodsA randomized crossover study was conducted, involving 15 participants (mean [SD] age, 25.4 [3.6]; mean [SD] body mass index, 22 [3]; 7 women [46.7%]). The study design involved a randomized sequence of sitting and leg shaking conditions, with each condition lasting for 20 min. Energy expenditure, respiratory rate, oxygen saturation, and other relevant variables were measured during each condition.ResultsCompared to sitting, leg shaking significantly increased total energy expenditure [1.088 kj/min, 95% confidence interval, 0.69–1.487 kj/min], primarily through elevated carbohydrate oxidation. The average metabolic equivalent during leg shaking exhibited a significant increase from 1.5 to 1.8. Leg shaking also raised respiratory rate, minute ventilation, and blood oxygen saturation levels, while having no obvious impact on heart rate or blood pressure. Electromyography data confirmed predominant activation of lower leg muscles and without increased muscle fatigue. Intriguingly, a significant correlation was observed between the increased energy expenditure and both the frequency of leg shaking and the muscle mass of the legs.ConclusionsOur study provides evidence that habitual leg shaking can boost overall energy expenditure by approximately 16.3%. This simple and feasible approach offers a convenient way to enhance physical activity levels.image
SEGUL: Ultrafast, memory‐efficient and mobile‐friendly software for manipulating and summarizing phylogenomic datasets
Authors: Handika Heru , Esselstyn Jacob A. 
Published: April 2024

AbstractPhylogenetic studies now routinely require manipulating and summarizing thousands of data files. For most of these tasks, currently available software requires considerable computing resources and substantial knowledge of command‐line applications. We develop an ultrafast and memory‐efficient software, SEGUL, that performs common phylogenomic dataset manipulations and calculates statistics summarizing essential data features. Our software is available as standalone command‐line interface (CLI) and graphical user interface (GUI) applications, and as a library for Rust, R and Python, with possible support of other languages. The CLI and library versions run native on Windows, Linux and macOS, including Apple ARM Macs. The GUI version extends support to include mobile iOS, iPadOS and Android operating systems. SEGUL leverages the high performance of the Rust programming language to offer fast execution times and low memory footprints regardless of dataset size and platform choice. The inclusion of a GUI minimizes bioinformatics barriers to phylogenomics while SEGUL's efficiency reduces economic barriers by allowing analysis on inexpensive hardware. Our support for mobile operating systems further enables teaching phylogenomics where access to computing power is limited.