bluuebunny/crossref_metadata_2025_split huggingface dataset:
Central limit theorem for intrinsic Fréchet means in smooth compact Riemannian manifolds
Authors: Hotz Thomas , Le Huiling , Wood Andrew T. A. 
Published: June 2024

AbstractWe prove a central limit theorem (CLT) for the Fréchet mean of independent and identically distributed observations in a compact Riemannian manifold assuming that the population Fréchet mean is unique. Previous general CLT results in this setting have assumed that the cut locus of the Fréchet mean lies outside the support of the population distribution. In this paper we present a CLT under some mild technical conditions on the manifold plus the following assumption on the population distribution: in a neighbourhood of the cut locus of the population Fréchet mean, the population distribution is absolutely continuous with respect to the volume measure on the manifold and in this neighhbourhood the Radon–Nikodym derivative has a version that is continuous. So far as we are aware, the CLT given here is the first which allows the cut locus to have co-dimension one or two when it is included in the support of the distribution. A key part of the proof is establishing an asymptotic approximation for the parallel transport of a certain vector field. Whether or not a non-standard term arises in the CLT depends on whether the co-dimension of the cut locus is one or greater than one: in the former case a non-standard term appears but not in the latter case. This is the first paper to give a general and explicit expression for the non-standard term which arises when the co-dimension of the cut locus is one.
Wear-Resistant Low-friction Atmospheric Pressure Plasma Spray Coatings for Sustainable (Bio-based Recyclable) Materials
Authors: Kaindl Reinhard , Kopp Dietmar Franz , Parizek Harald , Lackner Jürgen Markus , Waldhauser Wolfgang 
Published: June 2024

AbstractCoatings from polyetheretherketone (PEEK), polyamide 12 (PA12), molybdenumdisulfide (MoS2), zinc (Zn), and graphite (C) powder mixtures were deposited on PA6, PA12, and PEEK substrates by an atmospheric pressure plasma (APP) spray jet system. Several tenth of µm thick coatings on PA6 and PA12 substrates result in an almost halved surface roughness Ra ~8 µm, Rq ~10 µm and Rz ~60 µm, whereas a significant increase of all surface roughness parameters is observed for PEEK substrates (Ra < 1 µm → 4 µm, Rq < 1 µm → 5 µm, Rz < 5 µm → 20 µm). The surface roughness, powder composition, and selected APP process parameter strongly influence the coefficient of friction (COF) and specific wear rate ki of the APP coatings in rotational ball-on-disc tribological testing. The COF of PA12/MoS2/C coatings on PA6 substrates manufactured by selective laser sintering (SLS) is ~0.2 after 628 m sliding distance, resulting in a very low calculated ki of 6.3 × 10−7 mm3/Nm. A similarly low COF and ki was observed for PEEK coatings deposited at a current of 75 A and 60 mm jet–substrate distance on SLS PA12 substrate. Although the COF of Zn/C/MoS2 coatings on PEEK drops down below 0.1 after 1884 m sliding distance under nitrogen atmosphere the corresponding ki of 5.6 × 10−5 mm3/Nm is higher. Still all calculated specific wear rates are significantly lower than the reported values of polyamide-polytetrafluorethylene (PTFE)-polyethylene composites (1.9–8.0 × 10−2 mm3/Nm) and partly even outperform PEEK-PTFE composites (1.0 × 10−7–2.5 × 10−6), currently applied in demanding wear regimes.
The attainment of a patient acceptable symptom state in patients undergoing revision spine fusion
Authors: Issa Tariq Z. , Tarawneh Omar H. , Ezeonu Teeto , Haider Ameer A. , Narayanan Rajkishen , Canseco Jose A. , Hilibrand Alan S. , Vaccaro Alexander R. , Schroeder Gregory D. , Kepler Christopher K. 
Published: June 2024

Abstract
Introduction
Revision lumbar fusion is most commonly due to nonunion, adjacent segment disease (ASD), or recurrent stenosis, but it is unclear if diagnosis affects patient outcomes. The primary aim of this study was to assess whether patients achieved the patient acceptable symptom state (PASS) or minimal clinically important difference (MCID) after revision lumbar fusion and assess whether this was influenced by the indication for revision.

Methods
We retrospectively identified all 1–3 level revision lumbar fusions at a single institution. Oswestry Disability Index (ODI) was collected at preoperative, three-month postoperative, and one-year postoperative time points. The MCID was calculated using a distribution-based method at each postoperative time point. PASS was set at the threshold of ≤ 22.

Results
We identified 197 patients: 56% with ASD, 28% with recurrent stenosis, and 15% with pseudarthrosis. The MCID for ODI was 10.05 and 10.23 at three months and one year, respectively. In total, 61% of patients with ASD, 52% of patients with nonunion, and 65% of patients with recurrent stenosis achieved our cohort-specific MCID at one year postoperatively with ASD (p = 0.78). At one year postoperatively, 33.8% of ASD patients, 47.8% of nonunion patients, and 37% of patients with recurrent stenosis achieved PASS without any difference between indication (p = 0.47).

Conclusions
The majority of patients undergoing revision spine fusion experience significant postoperative improvements regardless of the indication for revision. However, a large proportion of these patients do not achieve the patient acceptable symptom state. While revision spine surgery may offer substantial benefits, these results underscore the need to manage patient expectations.
Langzeitresultate nach ultraschallassistierter Katheterthrombolyse bei akuten iliofemoralen Thrombosen
Authors: Langer S. , Kücük C. , Mühlberger D. 
Published: June 2024

Zusammenfassung
Hintergrund und Fragestellung
Unter der konservativen Standardbehandlung der proximalen Phlebothrombose (DVT) entwickeln 40–70 % der Patienten ein postthrombotisches Syndrom (PTS). Zur Vermeidung eines PTS kann in Einzelfällen eine chirurgische Thrombektomie oder eine interventionelle Rekanalisierung in Betracht gezogen werden. Ziel unserer Studie war die Untersuchung der Effektivität der frühzeitigen Intervention mittels ultraschallassistierter Katheterthrombolyse (UACDT) mit dem EKOS EndoWave Katheter im Langzeitverlauf.

Methodik
In einer monozentrischen retrospektiven Studie wurden 42 Patienten (49,9 ± 18,1 Jahre) nachuntersucht, die zwischen Juli 2011 und November 2019 mit einer UACDT bei iliofemoraler Thrombose behandelt wurden. Primäre Endpunkte waren die PTS-Rate gemessen anhand der Villalta-Skala sowie die Erhebung der krankheitsspezifischen Lebensqualität anhand des VEINS-QOL.

Ergebnisse
Bei 40 Patienten (95,2 %) konnte primär erfolgreich eine Rekanalisierung der Beckenetage bei einer durchschnittlichen Lyse-Dauer von 56,5 (SD ± 17,2) Stunden erreicht werden. Es wurden 22 Patienten (52,4 %) nach einem mittleren Beobachtungszeitraum von 50,4 Monaten (± 30,9) nachuntersucht. Die PTS-Rate lag insgesamt bei 27,3 % (6 Patienten). Das Venensystem zeigte sich in der Duplexsonographie bei 80 % der nachuntersuchten Patienten durchgängig.

Schlussfolgerung
Die UACDT als frühe thrombusbeseitigende Maßnahme bei proximaler DVT zeigt eine niedrige PTS-Rate im Langzeitverlauf und kann die krankheitsspezifische Lebensqualität dieser Patienten verbessern. Sie ist aber mit einem Risiko der Blutungskomplikation assoziiert, sodass die Indikationsstellung weiterhin kritisch gestellt werden sollte.
Unusual presentation of cat scratch disease: case report
Authors: Aslan Tuncay Sevgi , Akkoc Gulsen , Yilmaz Seyhan , Dizi Isik Aylin , Canizci Erdemli Pinar , Parlak Burcu , Buyuktas Aytac Didem , Abaci Capar Meryem Cagla , Almus Eda , Yapici Ozge , Binici Beyza , Ataizi Celikel Cigdem , Ocal Demir Sevliya 
Published: June 2024

AbstractCat scratch disease (CSD) is an infection caused by Bartonella henselae, presents with non-specific symptoms like lymphadenopathy, fever, and fatigue. It can progress to disseminated disease, leading to complications such as liver and splenic micro abscesses, osteomyelitis, encephalitis, and uveitis. Diagnosis is challenging due to varied presentations and limited tests. Treatment involves supportive care, with severe cases requiring antimicrobial therapy. In this report, we present a case of Cat scratch disease characterized by an atypical clinical manifestation, hepatosplenic and paravertebral involvement.
Rapid advance of climatic tree limits in the Eastern Alps explained by on-site temperatures
Authors: Körner Christian , Hiltbrunner Erika 
Published: June 2024

AbstractIn the European Alps, mean temperature has risen by 2.5 K since the end of the nineteenth century. A 2 K warming of the growing season has taken place in the last 4 decades only. The 2.5 K warming should rise the position of the climatic treeline by about 400 m. Actual shifts in uppermost tree positions reported here for the Austrian Defereggen Valley and the Swiss Lower Engadine region of the Eastern Alps reach only around 140 m of elevation above the limit of old trees that date back to the nineteenth century. Uppermost Pinus cembra trees of > 2 m height currently occur at c. 2500 m, representing elevation records for the Eastern Alps. In situ temperature records for 2022–2023 revealed seasonal mean temperatures for uppermost trees that are 1–3 K higher than the equilibrium treeline isotherm of c. 6 °C in both regions (corrected for temperature anomalies from long-term records). The 2 K span reflects microhabitat differences and two ways to define the season. Thus, tree advances lag behind the upslope shift of the treeline isotherm, on average, by more than 200 m. The uppermost trees currently grow under quite warm conditions with annual shoot length increments frequently reaching 20 cm. Even without additional future warming, the new steady-state climatic treeline will exceed the Holocene maximum elevation in the Eastern Alps substantially.
Do energy, inflation, and financial development stimulate economic welfare in India? Empirical insights from novel dynamic ARDL and KRLS simulations
Authors: Subhan Mohammad , Anjum Aqsa , Zamir M. N. , Kirikkaleli Dervis 
Published: June 2024

AbstractThe present study focuses on investigating the effect of renewable and non-renewable energy consumption (REC and NREC), financial development (FD), and inflation (INF) on economic welfare (EW) in India during 1990–2019. In this research, we employ a novel dynamic autoregressive distributed lag model and a kernel-based machine learning algorithm and regularise least squares to detect causal linkages among the variables. To measure the economic welfare index, this research uses the PCA analysis with GDP, human capital, environmental damage, number of employed persons, life expectancy at birth, and real consumption in households and by the government. According to the findings, the NREC and FD have been favourably contributing to EW. Conversely, the EW is adversely affected by REC. However, INF also has an adverse impact on EW, although it may be insignificant in the long run and significant in the short run.
Empowering Learners in Higher Education: Redesigning an Online Computer Science Course Through Universal Design for Learning Implementation
Authors: Redstone Ana E. , Luo Tian 
Published: June 2024

AbstractThis article focuses on the practical implementation of Universal Design for Learning (UDL) in an online computer science course, articulating the collaborative efforts between the instructional designer (the first author) and the faculty member to redesign the course using UDL principles. Specific instances of redesigned learning modules and artifacts in adherence to UDL principles and results and insights gained from the implementation are reported. The article concludes with recommendations for higher education faculty and instructional designers to consider when applying UDL in their online courses.
Addressing Multiple Responsibilities in the Early Stages of R&D with Provenance Assessment
Authors: Gondolf Janine 
Published: June 2024

AbstractA wealth of literature and best practices on Responsible Research and Innovation (RRI) document how it can be implemented in projects. However, each project is too specific to simply replicate existing patterns. Especially in early projects with a high degree of uncertainty, where indicators and measures cannot be applied, the so-called provenance assessment as a methodological change of perspective makes it possible to assess the procedural quality of research by means of narratives. A clear picture of the challenges for European bio-economy projects is sought by mapping the broader debate on "RRI in practice" in the context of biotechnology. The SUSPHIRE project is used as a case study to show how project-specific narratives integrate and signify RRI. By unpacking various concepts of "responsibility" that are already present in the project narrative at an early stage, I will show how this assessment differs significantly from other attempts to "do RRI". It is precisely in the absence of other criteria that the assessment of provenance can bring to the fore the specific form(s) of responsibility inherent in the development of projects.
Co-creating coastal sustainability goals and indicators
Authors: Engen Sigrid , Hausner Vera Helene , Mikkelsen Eirik , Gundersen Hege , Christie Hartvig , Falk-Andersson Jannike , Halpern Benjamin S. , Fauchald Per 
Published: June 2024

AbstractIndicators can be powerful tools to measure progress towards achieving societal goals, and many indicators have been developed for sustainability goals nationally and internationally. When indicators are developed solely through top-down approaches without engaging local knowledge, they often fall short of capturing local perceptions and concerns relevant to decision-making. The aim of this project was to co-create a Coastal Barometer and its component indicators, together with local knowledge-holders and communities, using the Ocean Health Index as a framework. As a first step, local knowledge-holders from six communities dispersed across Northern Norway were invited to articulate local sustainability goals and the required knowledge for eight broad topics pertaining to global OHI goals: small-scale fisheries, food production, sense of place, tourism, food production, clean waters, carbon storage and economy and livelihoods. In this paper, our main focus is the co-design phase of the Coastal Barometer, namely eliciting sustainability goals. We thus, present locally desired sustainability goals and sub-goals and the process of eliciting these goals. We also include suggestions from local knowledge-holders on how to reach these goals (i.e. proposed management measures), along with researchers’ assessment of data availability (part of the co-production process) for developing indicators to measure progress towards these goals. Finally, we discuss the benefits and challenges of co-developing sustainability goals and indicators with local knowledge-holders. We conclude that co-design can increase the quality of sustainability assessments by enriching the view of coastal sustainability. This knowledge can subsequently be used to align indicators with local sustainability goals as well as to the local context where the indicators will be applied.
Proinflammatory cytokines suppress stemness-related properties and expression of tight junction in canine intestinal organoids
Authors: Nakazawa Meg , Nagao Itsuma , Ambrosini Yoko M. 
Published: June 2024

AbstractRecent advancements in canine intestinal organoid research have paved the way for the development of enhanced in vitro models, crucial for exploring intestinal physiology and diseases. Despite these strides, there is a notable gap in creating specific in vitro models that focus on intestinal inflammation. Our study aims to bridge this gap by investigating the impact of proinflammatory cytokines on canine intestinal epithelial cells (IECs) within the context of organoid models. Canine intestinal organoids were treated with proinflammatory cytokines TNF-α, IFN-γ, and IL-1β. The expression of stem cell markers Lgr5, Sox9, Hopx, and Olfm4 was evaluated through RT-qPCR, while membrane integrity was assessed using immunofluorescence staining for tight junction proteins and transport assays for permeability. IFN-γ significantly decreased Lgr5 expression, a key intestinal stem cell marker, at both 24 and 48 h post-treatment (p=0.030 and p=0.002, respectively). Conversely, TNF-α increased Olfm4 expression during the same intervals (p=0.018 and p=0.011, respectively). A reduction in EdU-positive cells, indicative of decreased cell proliferation, was observed following IFN-γ treatment. Additionally, a decrease in tight junction proteins E-cadherin and ZO-1 (p<0.001 and p=0.003, respectively) and increased permeability in IECs (p=0.012) were noted, particularly following treatment with IFN-γ. The study highlights the profound impact of proinflammatory cytokines on canine IECs, influencing both stem cell dynamics and membrane integrity. These insights shed light on the intricate cellular processes underlying inflammation in the gut and open avenues for more in-depth research into the long-term effects of inflammation on intestinal health.
Efficacy of Omentopexy on Complications of Laparoscopic Sleeve Gastrectomy
Authors: Kara Yalcin Burak , Ozel Yahya , Yardimci Samet 
Published: June 2024

Abstract
Background
Laparoscopic sleeve gastrectomy (LSG) is a commonly performed type of bariatric surgery. Early complications of LSG include bleeding, leakage, pulmonary embolism, and surgical site infections. Most surgeons try to implement preventive methods, such as omentopexy. Staple line-imbrication, which has a difficult learning curve, often prevents complications. This study aimed to evaluate the effect of omentopexy on patients with imbricated LSG.

Material and Methods
The study applied a retrospective data analysis design to patients who underwent LSG between 2020 and 2023. All patients’ staple lines were imbricated, and patients were then divided into two groups: omentopexy group and control group. Patients’ demographic features, such as age, gender, height, weight, body mass index(BMI), bleeding, leakage, and reoperations, were recorded and examined retrospectively.

Results
A total of 1356 patients were included in the study (540 in omentopexy, 816 in control), of which the mean age was 37.9 ± 10.5 years, 82.3% were women, and mean BMI was 40.9 ± 5.8 kg/m2. The mean bleeding rate was 1.0% (1.3–0.7%), the mean leakage rate was 0.2% (0.2–0.2%, respectively), and the mean reoperation rate was 0.6% (0.7% and 0.5%, respectively). No statistically significant differences were observed.

Conclusion
Omentopexy is a technique that is widely used to prevent staple line complications. According to our study, omentopexy applied to an imbricated stapler line increased the operation time but did not affect bleeding or leakage ratios. This is the first study to evaluate the effect of omentopexy on imbricated staple lines. The findings of the study indicate that omentopexy has no additional benefit on early complications when using staple-line imbrication.

Graphical Abstract
Exogenous methyl jasmonate mediates tolerance of heat stress in Korean fir (Abies koreana)
Authors: Lee Da Young , Park Da Young , Park Hyeong Cheol 
Published: June 2024

AbstractHeat stress is a major environmental stress that affects the growth and development of plants. Korean fir (Abies koreana), a rare species endemic to South Korea, is sensitive to global climate change. The effect of exogenous methyl jasmonate (MeJA) on heat stress tolerance was, therefore, investigated in this species. During heat stress, the expression levels of eight genes (AkNAC19, AkMPK6, AkERF4, AkEFP, AkNAC2, AkbHLH, AkHSP17.6, and AkMYB123) were assessed in needles of A. koreana following treatment with 0, 0.1, 1.0, or 2.0 mM MeJA. Optimal upregulation of expression of most genes was observed 24 h post-treatment with 2.0 mM MeJA. Similar results were obtained when gene expression was analyzed 1, 2, 4, and 8 days post-treatment with 2.0 mM MeJA. Under heat stress conditions, plants treated with 2.0 mM MeJA initially showed a rapid decline in electrolyte leakage and higher chlorophyll content after 28 days of heat stress; however, opposite trends were observed in untreated plants, indicating that MeJA mediated tolerance to heat stress. Higher levels of expression of AkERF4, AkNAC2, and AkHSP17.6 were observed in MeJA-treated needles than in untreated needles, indicating these genes were strongly associated with MeJA-mediated heat tolerance. Therefore, these results suggest that the ability of Korean fir to tolerate abiotic stress is associated with endogenous MeJA synthesis or signaling, and identifies AkERF4, AkNAC2, and AkHSP17.6 as potential candidates for genes involved in the stress-tolerance mechanism.
The quality of mathematics teaching from a mathematics educational perspective: what do we actually know and which questions are still open?
Authors: Brunner Esther , Star Jon R. 
Published: June 2024

AbstractIn this survey paper we focus on aspects of the quality of teaching mathematics from several perspectives. We differentiate between effective aspects that are empirically proven and more normative ones that constitute “good teaching” but that are highly dependent on context. High quality of mathematics teaching includes characteristics from a generic point of view as well as those that rely upon more subject- and topic-specific features. In the paper we draw upon examples of the research traditions in Germany and in the US—where the discussion regarding quality of mathematics teaching has been particularly intensive—to provide a short overview about empirical key findings. We then describe open questions in this research field and conclude by proposing a conceptualization of high quality mathematics teaching that foregrounds the relationship between generic and topic-specific and also considers different possibilities for the measurement of the quality.
Classification Criteria for ANCA Associated Vasculitis – Ready for Prime Time?
Authors: Rathmann Jens , Mohammad Aladdin J. 
Published: June 2024

Abstract
Purpose of Review
This review aims to summarize the evolution and recent developments in the classification of ANCA associated vasculitis (AAV) and to summarize evaluations of the 2022 ACR/EULAR classification criteria of AAV in several cohorts.

Recent Findings
The classification of AAV has been a field of controversy for some time. The parallel existence of classification criteria and disease definitions produced some overlap in classification, leading to challenges when comparing different cohorts. The 2022 ACR/EULAR classification criteria derived from the largest study ever conducted in vasculitis account for significant changes in vasculitis classification with the integration of ANCA and modern imaging. These criteria show good performance compared to previous ones but also raise questions as ANCA serotypes have substantial impact on classification. In addition, there are some discrepancies with earlier agreed histopathological features of AAV disease phenotypes.

Summary
During the last 35 years, several sets of classification criteria have evolved to facilitate epidemiologic studies and clinical trials in AAV. While some of these criteria have been in use for many years, they were criticized due to either not using ANCA or not integrating surrogate markers for vasculitis but also due to overlapping when used in parallel. The long-awaited new ACR/EULAR criteria for AAV were published in 2022 and are the result of a large international study, introducing for the first time ANCA and modern imaging in the classification of AAV. Though the criteria show good performance, they bring several other challenges with practical application.