bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effects of a Dietary Supplement (PediaFlù) Plus Standard of Care in Children With Acute Tonsillopharyngitis/Rhinopharyngitis: Protocol for a Randomized Controlled Trial
Authors: Cardinale Fabio , Barattini Dionisio Franco , Sbrocca Federica , Centi Alessandro , Giuntini Greta , Morariu Bordea Maria , Herteg Dorina , Rosu Serban , Matei Cristian Radu 
Published: April 2024

Background
A dietary supplement containing Pelargonium sidoides extract, propolis, zinc, and honey has been recently developed and proven to be an effective adjuvant in clinical practice for seasonal diseases and the treatment of respiratory tract disorders.

Objective
This trial aims to verify the efficacy of the tested dietary supplement in a pediatric population with acute tonsillopharyngitis/rhinopharyngitis (ATR).

Methods
The trial includes children aged between 3 and 10 years with ATR ≤48 h, a negative rapid test for beta-hemolytic streptococcus or culture identification of nasal and/or pharyngeal exudates, and SARS-CoV-2 infection. The dietary supplement tested is an oral solution already on the market based on Pelagon P-70 (equivalent to Pelargonium sidoides d.e. 133.3 mg/100 ml), propolis, zinc, and honey. The product is administered at 5 ml 3 times a day for 6 days for children younger than 6 years and 10 ml 3 times a day for 6 days for children older than 6 years. The study design is open label, randomized, and controlled, with the tested dietary supplement plus standard of care (SoC) versus SoC alone. Patients are enrolled from 3 sites in Romania. The change in Tonsillitis Severity Score and number of treatment failures (using ibuprofen or high-dose paracetamol as rescue medication) are the primary end points. Based on the Tonsillitis Severity Score and the 2-sample comparison of the means formula with a 5% significance level, 80% power, and a minimally clinically important difference of 2 (SD 3.85) points, 120 patients are required. To account for potential screening failures and dropouts, we need to screen a population of approximately 150 children.

Results
Patient enrollment began on June 3, 2021 (first patient’s first visit), and ended on August 12, 2021 (last patient’s last visit). The data collection period was from June 3, 2021, to September 16, 2021. The study was funded in February 2023. Data analysis is currently ongoing (April 2024). We expect the results to be published in a peer-reviewed clinical journal in the third quarter of 2024 and presented at scientific meetings in the last quarter of 2024.

Conclusions
The data from this trial may help identify new adjuvant treatments for children with ATR when streptococcal infection is excluded by a negative rapid test, thereby avoiding unnecessary antibiotic administration.

Trial Registration
ClinicalTrials.gov NCT04899401 https://clinicaltrials.gov/study/NCT04899401

International Registered Report Identifier (IRRID)
DERR1-10.2196/53703
Effects of transpalatal arch wire dimension and temporary skeletal anchorage device position on maxillary molar intrusion
Authors: Wang Xiaoting , Zhao Yichen , Fan Mingyue , Zhou Ting , Fang Bing , Ye Niansong 
Published: April 2024

ABSTRACT

Objectives
To investigate the effects of transpalatal (TPA) wire dimension and temporary skeletal anchorage device (TSAD) position on maxillary molar intrusion.

Materials and Methods
The maxillary molar intrusion measurement system included a maxillary acrylic model, TPA, TSADs, and a three-dimensional Force/Moment (F/M) sensor. The intrusion patterns were categorized into six groups: buccal-mesial, buccal-distal, buccal-mesiodistal, palatal-mesial, palatal-distal, and palatal-mesiodistal. TPA wire dimensions were designed to be 0.7 mm, 0.9 mm, and 1.2 mm. The force and moment loads of the maxillary first molar were measured by the F/M sensor.

Results
Single buccal or palatal TSADs induced torquing movement, and single mesial or distal TSADs tended to promote tipping movement. Mesiodistal TSADs would have eliminated tipping, but accentuated torquing movement. The TPA significantly reduced the force and moment experienced by the maxillary first molar along three-dimensional axes. The thicker the TPA wire, the smaller the force and moment to which the maxillary first molar was subjected.

Conclusions
Precise placement of TSADs might have a substantial influence on tooth movement and should be determined in accordance with specific clinical requirements. Increasing the TPA wire dimension could diminish the tipping, torquing, and rotation during TSAD-assisted maxillary molar intrusion, but these tendencies could not be completely eliminated.
Increased cancer incidence among patients with hidradenitis suppurativa – a Danish nationwide register study 1977–2017
Authors: Andersen Rune , Rostgaard Klaus , Pedersen Ole , Jemec Gregor Borut Ernst , Hjalgrim Henrik 
Published: April 2024

Background: The chronic, inflammatory skin disease hidradenitis suppurativa (HS) (prevalence: 0.5%–1%, diagnostic delay: 7–10 years) primarily arises in younger adults and frequently coincides with autoimmune comorbidities and unhealthy life-styles (smoking and obesity). These factors are known to increase cancer risk, but despite this, information on cancer occurrence among HS patients is scarce.
Materials and methods: A nationwide retrospective register-based study assessing relative risk of cancer – overall and by anatomical site – following HS diagnosis expressed as standardized incidence ratios (SIRs), which is ratios between observed cases among all Danes diagnosed with HS since 1977 and expected cases based on cancer incidence rates of the entire Danish population during the same period.
Results: Participants consisted of a cohort of 13,919 Danes with HS, who during an average of 14.2 years of follow-up developed a total of 1,193 incident cancers, corresponding to a 40% increased risk (SIR = 1.4, 95% CI: 1.3 to 1.4, p < 0.001). Increased risks were observed for cancers of the respiratory system, oral cavity and pharynx, digestive organs and peritoneum, urinary tract, and the lymphatic tissues.
Interpretation: These findings underline an unmet need for health monitoring, lifestyle interventions and cancer screening if and when relevant.
Kecerdasan Emosional dan Supervisi Kepala Sekolah Berpengaruh Terhadap Disiplin Kerja Guru Sekolah Dasar
Authors: Karmini Ni Kadek Ayu , Suniasih Ni Wayan 
Published: April 2024

Upaya peningkatan kualitas pendidikan dipengaruhi oleh tingkat kedisiplinan dan profesionalitas guru dalam pelaksanaan tugas pokok dan fungsinya di sekolah. Upaya untuk meningkatkan kualitas guru masih belum maksimal terwujud, hal ini dilihat dari banyaknya guru yang masih melakukan pelanggaran disiplin kerja yang bisa ditemui di media elektronik, media cetak maupun di lapangan. Tujuan penelitian ini untuk menganalisis pengaruh kecerdasan emosional dan supervisi kepala sekolah terhadap disiplin kerja guru. Penelitian ini menggunakan rancangan ex post facto dengan studi pendekatan korelasional. Populasi dalam penelitian ini adalah guru-guru yang berjumlah 70 orang. Sampel pada penelitian menggunakan teknik sampling total yaitu semua anggota populasi menjadi sampel. Metode pengumpulan data yang digunakan adalah metode non tes, yaitu angket. Data dianalisis menggunakan analisis regresi linier sederhana dan analisis regresi linier ganda. Berdasarkan hasil analisis yang dilakukan maka, (1) terdapat pengaruh yang signifikan kecerdasan emosional terhadap disiplin kerja guru berdasarkan Fhitung = 26,798 > Ftabel = 3,98 dengan kontribusi sebesar 10,45%, (2) terdapat pengaruh yang signifikan supervisi kepala sekolah terhadap disiplin kerja guru berdasarkan Fhitung = 30,836 > Ftabel = 3,98 dengan kontribusinya sebesar 21,75%, dan (3) terdapat pengaruh yang signifikan kecerdasan emosional dan supervisi kepala sekolah terhadap disiplin kerja guru berdasarkan 15,910 > dan 3,13 dengan kontribusinya sebesar 32,20%. Sehingga dapat disimpulkan bahwa terdapat pengaruh yang signifikan kecerdasan emosional dan supervisi kepala sekolah terhadap disiplin kerja guru dengan kontribusi sebesar 32,20%, maka terdapat faktor lain yang mempengaruhi disiplin kerja guru selain kecerdasan emosional dan supervisi kepala sekolah. Implikasi penelitian ini dapat dijadikan sebagai referensi bagi peneliti lain.
Tingkatkan Hasil Belajar Muatan IPS Tema Berbagai Pekerjaan Kelas IV Dengan Menggunakan Media Video Animasi
Authors: Karma Yasa Yogi , Ndara Tanggu Renda  , I Nyoman Laba Jayanta  
Published: April 2024

Penelitian ini dilatarbelakangi oleh kuaranganya media pembelajran inovatif di sekolah yang menyebabkan guru jarang menggunakan media sehingga pembelajaran menjadi monoton. Hal tersebut berdampak pada siswa dimana minat belajar siswa menuruh sehingga hasil belajar siswa pun ikut menurun. Penelitian ini bertujuan untuk menghasilkan rancang bangun media video animasi pada muatan pembelajaran IPS tema 4 berbagai pekerjaan kelas IV Sekolah Dasar yang telah teruji validitas isi dan kepraktisannya. Pada penelitian pengembangan ini dikembangkan sebuah video animasi yang bermuatan pembelajaran IPS. Penelitian pengembangan ini berpedoman pada prosedur ADDIE. Subjek dari penelitian pengembangan ini yaitu 2 orang untuk ahli materi,, 2 orang untuk ahli media dan desain, 2 orang guru untuk uji praktisi, 15 orang siswa sebagai respon. Metode pengumpulan data dari penelitian pengembangan ini yaitu metode wawancara dan instrumen yang digunakan berupa rating scale dengan menggunakan skala 5. Hasil penelitian pengembangan ini dianalisis menggunakan rumus Mean untuk mendapatkan rata-rata skor dari data yang diperoleh. Skor validasi video pembelajaran animasi ahli materi 4,6 dengan kualifikasi “sangat baik”, ahli media 4,6 dengan kualifikasi “sangat baik”, ahli desain 4,6 dengan kualifikasi “sangat baik”, uji praktisi 4,8 dengan kualifikasi “sangat baik” dan respon siswa 4,7 dengan kualifikasi “sangat baik”. Oleh karena itu video animasi pada tema 4 berbagai pekerjaan kelas IV SD dikualifikasikan “sangat baik”. Sehingga dari analisis video animasi pada muatan pembelajaran IPS Tema 4 berbagai pekerjaan yang melalui uji coba dari beberapa ahli dapat dinyatakan Valid dan praktis digunakan dalam proses pembelajaran.
Aktivitas Pembelajaran Berbantuan Media Pembelajaran Wizer.Me Meningkatkan Literasi Numerasi dan Kemampuan Metakogntif pada Materi Bilangan Bulat
Authors: I Ketut Puspayoga Ariana  , I Wayan Widiana  , Kadek Yudiana  
Published: April 2024

Aktivitas siswa dalam pembelajaran hanya terbatas pada aktivitas mendengarkan penjelasan dari guru, dan penugasan. Hal ini berdampak pada kurangnya kemampuan literasi numerasi dan kemampuan metakognitif siswa. Tujuan penelitian ini yaitu mengembangkan aktivitas pembelajaran berbantuan media pembelajaran wizer.me terhadap literasi numerasi dan kemampuan metakogntif pada materi bilangan bulat. Penelitian ini merukan penelitian pengembangan dengan menggunakan model pengembangan 4-D. Subjek penelitian terdiri dari 4 ahli isi aktivitas pembelajaran. Subjek uji coba produk terdiri dari 2 guru dan 39 siswa. Metode pengumpulan data yang digunakan pada penelitian pengembangan ini adalah menggunakan metode wawancara, observasi, studi dokumentasi, rating scale, tes dan kuesioner. Instrument yang digunakan yaitu kuesioner. Metode dan teknik analisis data yang digunakan yaitu metode analisis deskriptif kualitatif, analisis deskriptif kuantitatif, dan analisis statistik inferensial. Hasil penelitian yaitu diperoleh signifikasi sebesar 0,000 baik di uji secara bersama-sama maupun terpisah. Hal ini berarti, signifikasi yang diperoleh lebih kecil dari 0,05 jadi terdapat perbedaan yang signifikan literasi numerasi dan kemampuan metakognitif antara siswa yang mengikuti aktivitas pembelajaran berbantuan media pembelajaran wizer.me dengan siswa yang mengikuti aktivitas pembelajaran tanpa berbantuan media pembelajaran wizer.me. Penggunaan aktivitas pembelajaran berbantuan media pembelajaran wizer.me dapat memberikan dampak positif dalam pembelajaran.
Model Pembelajaran Think Pair Share Berbantuan Kartu Bergambar Terhadap Keterampilan Menulis Siswa Kelas V SD
Authors: Dewi Kadek Budi Apsari , Ganing Ni Nyoman , Suniasih Ni Wayan 
Published: April 2024

Penelitian ini bertujuan untuk mengetahui pengaruh yang signifikan model Think Pair Share berbantuan kartu bergambar terhadap keterampilan menulis siswa kelas V SD. Populasi dari penelitian ini adalah siswa Kelas V SD di Gugus VII Sayan Kecamatan Ubud yang berjumlah 150 orang. Jenis penelitian ini adalah eksperimen semu dengan rancangan Non-Equivalent Control Group Design. Penentuan sampel dalam penelitian ini menggunakan teknik random sampling. Rata-rata nilai kelompok eksperimen yaitu sebesar 73,57 dan rata-rata nilai kelompok kontrol sebesar 64,05. Data keterampilan menulis dikumpulkan dengan tes keterampilan menulis dilengkapi rubrik penilaian. Data yang dikummpulkan dianalisis dengan uji-t poleed variance. Hasil analisis uji-t menunjukkan bahwa t hitung sama dengan 4,435 lebih dari ttabel sama dengan 2,000, maka H0 ditolak. Hasil penelitian menunjukkan bahwa terdapat pengaruh yang signifikan model Think Pair Share berbantuan kartu bergambar terhadap keterampilan menulis siswa kelas V SD.
The impact of crowdsourcing and user-driven innovation on R&D departments’ innovation activity: Application of multivariate correspondence analysis
Authors: Szopik-Depczyńska Katarzyna , Dembińska Izabela , Barczak Agnieszka , Kędzierska-Szczepaniak Angelika , Fazio Maria , Ioppolo Giuseppe 
Published: April 2024

Research background: In enterprise practices, innovation management is taking on more and more open forms. New, creative sources of inspiration are being sought. More and more companies are opening up to cooperation with external people or entities, thus entering a path of open innovation and crowdsourcing. This development is facilitated by increasingly large numbers of online and virtual communities. The idea is to use the potential of the crowd — collective intelligence and creativity. As the strategy is still developing, knowledge in this area is limited. There is a paucity of research on the impact of crowdsourcing on R&D departments and their innovative activities.
Purpose of the article: The study aims to determine whether the use of customer support in the form of crowdsourcing affects the innovative activities of R&D departments that implement user-driven innovation (UDI).
Methods: An original questionnaire was used for the study. Fifty-seven R&D departments in Poland participated in the research. A correspondence analysis, performed on the basis of the Burt matrix, was applied for the analysis. The authors also used Cramer's V correlation coefficients. Examination of the acquired correlation coefficients reveals the existence of four distinct categories of enterprises regarding the usage of crowdsourcing and implementation of product innovations, completed R&D projects, employment in R&D departments, and percentage of revenue allocating in R&D works.
Findings & value added: Research has shown that R&D departments positively evaluate the effects of using UDI in market research analyses of customer purchasing behavior. It helps to create or improve products or services offered on the market, especially in the field of customization, using the information from national research and development units at the same time. Their purpose is mainly to increase the product range. The findings can help academics and practitioners improve the body of knowledge about the determinants of innovation activity, especially concerning relationships with customers and user-driven innovation practices.
Organizational and tactical features of the inspection during the investigation of hooliganism committed by football fans
Authors: Klimov B. V. 
Published: April 2024

The article examines the organizational and tactical features of the review and during the investigation of hooliganism committed by football fans.
The methodological basis of the study was the generalized data of the studied materials of archival criminal proceedings on the facts of hooliganism committed by football fans, as well as the consolidated data of surveys of investigators (inquisitors) and operatives of criminal police units. The used survey methods (interviews, questionnaires), analysis, and synthesis allowed the author to obtain reliable data, summarize scientific results and come to the following conclusions: 1) the review is a comprehensive priority and urgent investigative (search) action, which is characterized by the greatest informativeness at the primary stage of the investigation of hooliganism committed by football fans, in particular, to establish the circumstances that are important for the organization of the work of the investigative- operational group, the involvement of additional forces and means, the correct choice of the algorithm of actions, putting forward versions, detecting, extracting, fixing and storing ideal and material traces; 2) nodal places and objects subject to inspection, which store the largest amount of evidentiary and orienting information, are singled out; 3) the most informative objects of review are determined to establish the circumstances of the event and the promptness of decision-making regarding the identification and detention of criminal offenders «on hot pursuit» at the primary stage of the investigation of hooliganism committed by football fans; 4) the main methods most effective during the investigation of hooliganism committed by football fans during the inspection of the scene were established. 5) it is claimed that quadcopters are an effective tool, the use of which in this category of criminal offenses can significantly increase the quality and effectiveness of the inspection.
Features of criminal characteristics of crimes in the sphere of intellectual property
Authors: Kravchuk P. Yu. , Shalavinskyi O. V. 
Published: April 2024

The article is devoted to the peculiarities of the forensic characteristics of crimes in the field of intellectual property. It is noted that the Constitution of our country guarantees every citizen the right to the results of his intellectual and creative activity; no one can use or distribute them without his consent, with exceptions established by law. However, criminals violate this right and commit corresponding criminal offenses, the responsibility for which is provided for by Articles 176, 177, 203-1, 229 of the Criminal Code of Ukraine. At the same time, the formulation of the forensic characteristics of any criminal offense is an important stage of its proof, as it allows not only to determine the circumstances that need to be established, but also to draw up a further investigation plan and tactics for conducting investigative (search) actions.
It was concluded that the forensic characteristics of criminal offenses in the field of intellectual property include: the method of committing the crime, the object of the criminal offense, the identity of the criminal and typical traces of the crime.
The criminal’s choice of the subject of the criminal offense is determined, first of all, by the level of his education, the presence of certain professional skills and knowledge necessary for the implementation of the plan, and the technical side of the issue. All this is especially true for crimes related to copyright infringement in the field of distribution of audio and video products and computer information. Because a person who does not have certain special skills and education is not able to develop a crime plan and implement it. In addition, the criminal must first have access to the object of criminal trespass, and therefore know the technical features of its carrier and the organization of the work of the relevant enterprises, corporations, companies, firms and the like, in whose custody a certain desired work is located.
It has been established that the typical traces of these crimes are characterized by certain features in the process of trace creation, namely: their commission is mostly disguised as ordinary economic transactions; the tools used to commit them are significantly different from those used to commit other crimes; traces usually remain in various accounting, management or technological documents; the very objects of the criminal offense can be used within the framework of legitimate economic transactions.
National legislation as a source of the obligation to extradite or prosecute (aut dedere aut judicare)
Authors: Kosianenko S. O. 
Published: April 2024

The article, based on the study of doctrinal developments and the practice of states, reveals the issue of national legislation as a source of the obligation to extradite or prosecute (aut dedere aut judicare). The article highlights the position of the UN International Law Commission on the role of national legislation and state practice in implementing the obligation to extradite or prosecute; the practice of certain states (Finland, Estonia, Macedonia, Azerbaijan, Ukraine) regarding the legal establishment of the obligation to extradite or prosecute is considered; the measures that states should follow at the national level in order to effectively implement the principle of aut dedere aut judicare are defined.
The article establishes that the determination of the legal nature and scope of the obligation aut dedere aut judicare is possible through the study of various types of sources in which this obligation is established (treaties, customs, international and national court decisions, national legislation of states). The obligation to extradite or prosecute has traditionally been established by international treaties of various types, the number of which is constantly increasing. The participation of many states in such international treaties (of a universal, regional or bilateral nature) is a reflection of the existing national practice of the states regarding the implementation of the principle of aut dedere aut judicare.
It is substantiated that, along with treaties and customary (at least for the most serious international crimes) enshrining the principle of aut dedere aut judicare, national criminal law is an important source of the obligation to extradite or prosecute. The effective implementation of the principle of aut dedere aut judicare in each specific case will depend on the state’s fulfillment of both its international obligations and the implementation of the necessary measures (in particular, regarding the establishment of jurisdiction over offenders and criminal offenses) defined in national legislation with regard to extradition and prosecution.