bluuebunny/crossref_metadata_2025_split huggingface dataset:
The clinical characteristics and implications of acute kidney injury during induction therapy for acute promyelocytic leukemia
Authors: Shen Kai , Yang Chenlu , Huang Jie , Shuai Xiao , Niu Ting , Ma Hongbing 
Published: February 2025

BackgroundDual induction with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) has made acute promyelocytic leukemia (APL) a curable disease. However, differentiation syndrome (DS) can be a life-threatening complication of induction therapy. It is considered to result from a severe systemic inflammatory response mediated by increased expression of cytokines, chemokines, and adhesion molecules on differentiating blast cells. The kidney, as a vital organ rich in the capillary endothelium, could be targeted by differentiating blasts in DS. Acute kidney injury (AKI) is a rare but severe consequence of DS secondary to ATRA and ATO induction and can result in renal failure and early mortality. Nevertheless, its clinical characteristics and impact on APL prognosis have yet to be elucidated.ObjectivesThe aim of this study was to describe the clinical characteristics of DS-related AKI in patients with APL and its impact on patient prognosis.MethodsThis was a retrospective study from a single center in a real-world setting. APL patients who developed AKI during ATRA- and ATO-based induction were included. The patients’ clinical/laboratory data and outcome information were retrieved from the electronic medical records.ResultsFrom January 2011 to March 2024, a total of 26 out of 572 (4.5%) APL patients were identified as having AKI during dual induction. Among them, eight patients received continuous renal replacement therapy, and 3/8 patients experienced early death (ED), which was defined as death within 3 months of diagnosis. Among the five non-ED patients, three did not recover from renal function and were still dialysis-dependent during the follow-up. The estimated 2-year overall survival rate for all patients was 42%, and the ED rate was 30.8%. Survival analysis revealed that a greater tumor burden, a rapidly increasing WBC count, worse coagulation parameters, and persistent renal dysfunction were associated with a more adverse prognosis.ConclusionAKI is a rare but severe complication of DS in the ATRA + ATO dual-induction era of APL. It is associated with a high ED rate and dismal long-term survival. Some patients develop irreversible renal dysfunction and become dialysis-dependent after leukemia remission. Thus, the management of AKI in APL patients is still a clinical challenge, and a deeper understanding of its pathogenesis, along with multidisciplinary efforts, is needed.
Factors accounting for limited sexual reproduction in a long-lived unisexual plant species
Authors: Bisang Irene , Collart Flavien , Vanderpoorten Alain , Hedenäs Lars 
Published: February 2025

IntroductionPlant dispersal directly depends on reproduction success, and hence, on sexual systems. In bryophytes, wherein fertilization involves a continuous film of water between male and female sexual organs, reproduction in unisexual species involves the sympatric distribution of male and female sex-expressing individuals. Here, we determine whether these conditions are controlled by the environment. In particular, we test the hypotheses that (i) sex-expressing males and females exhibit different ecological niches and (ii) environmental variation drives sex expression, sporophyte formation, and hence, dispersal capacities.MethodsWe scored 1,080 specimens of the unisexual moss Abietinella abietina across Sweden as non-sex expressing, expressing female or male, or sporophytic. We tested whether reproductive stages were related to latitude. Topography and climatic conditions at 1-km resolution were employed to measure niche overlap between (i) sex-expressing and non-expressing and (ii) male and female specimens. We finally modelled sex expression and sporophyte production depending on these topo-climatic predictors.ResultsAmong the 63% of reproductive samples across the entire latitudinal gradient, females outnumbered males by a factor 5.6, and 8% of the female samples bore sporophytes. Although the distribution of the sexes was not explained by topo-climatic variables, the probability of sex-expressing samples being male increased with latitude. It resulted in a higher regional sex ratio in the North than in southern regions. Successful sexual reproduction, in terms of sporophyte occurrence, was confined to central Sweden. It was predicted by intermediate to increasing precipitation seasonality and intermediate temperature values.DiscussionDespite a high level of sex-expression, and no significant differences of niche preference between males and females, sporophyte occurrences were rare. Our results suggest that sporophyte formation was determined by mate availability and macro-climatic conditions, the latter possibly affecting fertilization success. We further infer that environmental conditions at the pre-zygotic stage have lower than expected effects on the overall distribution of this moss. Modelling environmental data at higher resolution, smaller scale and expanding geographic coverage to include more sporophyte occurrences, and comparing genetic diversity in sporophytic with non-sporophytic populations, are future lines of this research.
Social media usage and cyberbullying: the moderating role of tie strength
Authors: Ni Jinru , Fu Hongyu , Zhu Yajing , Li Zewen , Wang Shuyi , Su Haoran 
Published: February 2025

IntroductionCyberbullying is a pervasive issue in the digital age, closely linked to social media usage. However, existing research has largely overlooked the role of tie strength on social media platforms in shaping cyberbullying dynamics. This study, grounded in tie strength theory and medium theory, investigates the association between social media usage and cyberbullying, focusing on how tie strength moderates this relationship.MethodsA sample of 813 healthy adults (Mage = 20.06 ± 2.30 years, 498 females) completed an online survey, including the Chinese version of the Social Network Site Intensity Scale and the Cyberbullying Inventory for College Students (CICS).Results(1) Tie strength varies from platform to platform. The order of tie strength between users and the four platforms is as follows: WeChat &gt; Bilibili &gt; Weibo &gt; Douyin. (2) Strong-tie social media platforms exhibited higher levels of users’social media engagement compared to those with weak ties. (3) Weak ties significantly moderated the relationship between social media usage and cyberbullying, whereas strong ties did not. Increased social media usage was associated with a higher likelihood of both engaging in and being a victim of cyberbullying on weak-tie platforms, while strong-tie platforms showed a lower likelihood of both engaging in or being a victim of cyberbullying with increased usage.ConclusionThese findings highlight the interplay between tie strength theory and medium theory in explaining cyberbullying dynamics and underscore the need for platform-specific interventions to address this pervasive issue.
Lying flat to play on smartphone excessively: the role of self-esteem
Authors: Zhu Shuhua , Wang Lishen , Gan Yulu 
Published: February 2025

IntroductionWith the rapid development of their countries, Chinese young people today face intense stress. Some cope by striving for high-quality resources (involution), while others adopt a passive approach, lowering their desires (lying flat). This study explores the relationship between lying flat and problematic smartphone use (PSU), focusing on the role of self-esteem.MethodsWe conducted three studies (N = 886) using both cross-sectional (Study 1) and experimental (Study 2 and Study 3) designs to examine the correlational and causal links between lying flat, self-esteem, and PSU.ResultsThe studies demonstrated a significant relationship between lying flat and PSU, with self-esteem serving as a mediator. Additionally, Study 3 showed a causal effect of self-esteem on smartphone use desire.DiscussionThese findings provide insight into why and how lying flat affects self-esteem and smartphone use behaviors and desires, highlighting the psychological mechanisms behind the trends observed in Chinese youth.
A cross-sectional study of the current status of psychological health and its correlation with academic performance in medical students: taking medical students in a medical university in China as examples
Authors: Chunhong Han , Jingjing Ding , Huan He , Peiyao Zheng , Xiaona Zhang , Xiaowen Yang , Aiming Zheng 
Published: February 2025

BackgroundThe psychological health problems are becoming increasingly prominent among medical students under the heavy academic stress and high-intensity clinical internships. This study examines the psychological health of medical students in a Chinese university and its impact on academic performance, aiming to inform targeted interventions.Methods2022 undergraduate and postgraduates from an independent medical university in Eastern China were selected to score using the Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7(GAD-7), Insomnia Severity Index (ISI), Perceived Stress Scale (PSS), and Beck Scale for Suicide Ideation(BSSI); and the total grade point averages (GPAs) of 2022 undergraduates in the first and second academic years were determined to analyse the main psychological influencing factors.ResultsThe general survey of 2022 new medical students at admission showed that the various scores of postgraduates were higher than those of undergraduates. After two semesters, the percentage of students scored higher in unhealthy psychology indicators was increased in both postgraduates and undergraduates, but the differences between two groups were decreased. Analysis of the first and second-year academic performances of 2022 undergraduates revealed that assessment scores of PHQ-9, PSS, ISI, and BSSI had a correlation with the total GPA. However, no correlation was found between the GAD-7 values and the GPA. The PHQ-9 scores and major categories were identified as independent factors influencing the average GPA.ConclusionThe undergraduates face significant challenges in depression, anxiety, insomnia, and perceived stress, and these have negative effects on their academic performances; in particular, the depressive symptoms and perceived stress can significantly reduce their academic performances. In contrast, the psychological health statuses in the postgraduates tend to deteriorate as the semester progress.
Social robots in adult psychiatry: a summary of utilisation and impact
Authors: Kling Maja , Haeussl Alfred , Dalkner Nina , Fellendorf Frederike T. , Lenger Melanie , Finner Alexander , Ilic Julia , Smolak Irina S. , Stojec Lena , Zwigl Ina , Reininghaus Eva Z. 
Published: February 2025

Social robots are increasingly becoming more prevalent in healthcare, including nursing, geriatric care, and treatment for children on the autism spectrum. Their assistance is believed to hold promise in mitigating the effects of staffing shortages and enhancing current mental health treatment. Nevertheless, the application of social robotics in psychiatry remains restricted and controversial. This scoping review aims to provide an overview of the literature on social robots in adult psychiatry concerning their use, effects, and acceptability. We conducted a literature search, including PubMed and PsycINFO, to identify literature on robot interventions for adult psychiatric patients. Methodological quality was assessed using the ‘Mixed Methods Appraisal Tool’. Usage and target variables were unique to every included original study (N = 7) and suggested a wide range of possible implications for patient treatment and care. Social robots were used to reduce symptoms, improve functioning, and gain insights into characteristic features of specific mental health conditions. The included studies were concerned with the following diagnoses: schizophrenia (N = 3), autism spectrum disorder (N = 2), and intellectual disability (N = 2). The sample sizes were too small to generalise the outcome, but overall trends showed some positive effects on the selected symptoms. Observations and participant feedback suggested high acceptance and enjoyment of the users. Although the evidence regarding the benefits of robotic interventions in adult psychiatry is still low, it suffices to assume that investing in larger, randomised, and controlled trials is worthwhile and promising.Systematic review registrationasprediced.org, identifier 128766.
Caste, local governance effectiveness, and multidimensional poverty in rural India: some evidences
Authors: Ogbonna Amarachi Onyeyirichi , Ekuban Charles Aaron Adams , Muralee Krishnan C. , Viswanathan P. K. 
Published: February 2025

IntroductionThis study explores the relationships between local governance effectiveness, population densities of Scheduled Castes (SC) and Scheduled Tribes (ST), and rural multidimensional poverty in India, using data from the 2011 Indian Census, 2011 Socio-Economic and Caste Census (SECC), 2020 Mission Antyodaya, and 2019/21 National Family and Health Survey (NFHS).MethodsThe research examines how SC/ST population densities and local governance effectiveness are associated with the Multidimensional Poverty Index (MPI) across Indian states through regression and correlation analysis.ResultsThe study’s findings reveal a national, rural MPI of 0.110, with 26% of the rural population experiencing multidimensional poverty. The study’s results also show that a statistically significant negative correlation exists between rural MPI and local governance effectiveness, with a 0.32% reduction in MPI for every 1% improvement in governance effectiveness. Conversely, higher SC and ST population densities are associated with increased MPI, with a 0.14% rise in MPI for each 1% increase in these densities. The study also highlights that ST population density has a stronger association with MPI than SC population density, indicating greater vulnerability to multidimensional poverty in areas with higher ST populations.DiscussionOverall, the study underscores the importance of effective local governance in reducing rural poverty and suggests targeted efforts in areas with high SC and ST densities, particularly ST, to alleviate poverty. It also emphasizes the need for up-to-date data to understand and address rural poverty comprehensively.
Epidemiological investigation of poultry infectious in Kazakhstan (2021–2024)
Authors: Zikibayeva Karlygash B. , Svanbayev Asset A. , Akhmetsadykov Nurlan N. , Kudaibergenova Kamshat N. , Akhmetsadykova Shynar N. , Nurolda Ernur N. , Kydyrmanov Aidyn I. 
Published: February 2025

IntroductionThis study examines the epidemiological dynamics and genetic diversity of major avian infectious diseases in Kazakhstan, including highly pathogenic avian influenza (HPAI), Newcastle disease virus (NDV), and others. Using official data, laboratory diagnostics, and surveys, we identified high prevalence rates and virulent strains, exposing gaps in vaccination coverage and biosecurity practices. Continuous monitoring, improved vaccination strategies, and robust biosecurity measures are essential to reduce disease impact and ensure sustainable poultry farming.MethodsA cross-sectional study was conducted to assess the prevalence and genetic diversity of major avian infectious diseases in Kazakhstan. Data sources included official reports, laboratory diagnostics (RT-PCR, ELISA, and sequencing), and a survey of veterinary specialists. Serum samples were analyzed to evaluate antibody responses and vaccine efficacy. Genetic and phylogenetic analyses were conducted for key pathogens, while a questionnaire provided insights into farm-level disease control practices.ResultsAnalysis of official data recorded 27 outbreaks of avian diseases in Kazakhstan from 2005 to 2023, primarily involving HPAI and NDV. Our research further identified virulent strains such as NDV genotype VII and infectious bursal disease virus (IBDV) variants linked to global lineages. Serological studies revealed widespread exposure to pathogens, including Mycoplasma gallisepticum (MG), Mycoplasma synoviae (MS), chicken anemia virus (CAV), Ornithobacterium rhinotracheale (ORT), and low-pathogenic avian influenza (LPAI) H9, underscoring deficiencies in vaccination coverage. Farm surveys also identified weaknesses in biosecurity measures and inconsistencies in vaccination protocols.DiscussionThe findings underscore the urgent need for enhanced biosecurity measures, standardized vaccination programs, and routine monitoring to mitigate the impact of avian infectious diseases. This integrated approach offers valuable insights to support evidence-based decision-making for effective poultry health management in Kazakhstan.
Pemodelan Optimalisasi Pengembangan UKM Produsen Kerajinan Kayu Suparman Mebel Pundong, Bantul Melalui Promosi Website Dan Manajemen Persediaan Bahan Baku
Authors: MZ Yumarlin , Bororing Jemmy Edwin , Zulekha Rahmawaty  , Budi anggoro sajiwo  , Asni eriana ashari  
Published: February 2025

Kegiatan pengabdian ini bertujuan mengembangkan sistem pemodelan optimasi guna meningkatkan Usaha Kecil Menengah (UKM) dalam sektor kerajinan kayu, dalam produksinya di Suparman mebel Desa Soka, Seloharjo, Pundong Bantul Yogyakarta. Upaya utama difokuskan pada optimalisasi pemanfaatan teknologi, terutama dalam promosi melalui website sebagai sarana untuk menjangkau pasar lokal dan nasional. Selain itu, manajemen persediaan bahan baku dijadikan fokus utama untuk meningkatkan efisiensi produksi dan keuntungan bisnis. Kegiatan pengabdian ini mengimplementasikan persamaan linear simultan terkait produksi, di mana metode eliminasi Gauss-Jordan digunakan sebagai akurasi perhitungan biaya serta memberikan rekomendasi konkret untuk mengoptimalkan manajemen persediaan dan perhitungan produksi. Hasilnya adalah estimasi produksi yang terbukti dalam mengelola persediaan bahan baku, mencegah pemborosan, dan meningkatkan profitabilitas bisnis. Kegiatan pengabdian ini memberikan bukti konkret terhadap efektivitas dalam meningkatkan daya saing UKM Kerajinan kayu Suparman Mebel,Yogyakarta.
Актуальное представление лексем с компонентом ‘Auto’ в немецкоязычных СМИ (на материале корпуса новостных текстов Westdeutsche Allgemeine Zeitung)
Authors: Горожанов А.И. , Степанова Д.В. 
Published: February 2025

Цель исследования — изучить контексты употребления лексем, содержащих основу ‘Auto’ (автомобиль) на материале сбалансированного лингвистического корпуса новостных статей газеты Westdeutsche Allgemeine Zeitung (2024 год издания). Новизна работы заключается в том, что самые современные публикации указанной газеты впервые исследуются с применением оригинального отечественного программного комплекса «Генератор сбалансированного лингвистического корпуса и корпусный менеджер». В ходе исследования в автоматическом режиме был собран корпус новостных текстов; произведен поиск в корпусе по лемме и по части токена (началу, середине, концу) — тем самым был разработан метод поиска, который можно применять в сходных исследованиях; в полученных контекстах были выделены тематические доминанты (отказ от автомобиля / переход к электромобилям, экономия / чрезмерные траты при использовании автомобилей, преступления, аварии и несчастные случаи, неудачи экономического характера / убытки / неприятности), которые имеют отрицательную коннотацию. Положительно коннотированные контексты были зафиксированы лишь в единичных случаях. Таким образом, в рассмотренном издании фиксируется преимущественно отрицательная повестка в отношении личного автотранспорта. Исследование имеет перспективу в части создания баз данных оценочных маркеров с учетом жанровой специфики различных текстов.
The aim of the study is to examine the contexts of the lexemes containing the stem ‘Auto’ (car) using the balanced linguistic corpus of news articles from the Westdeutsche Allgemeine Zeitung newspaper (published in 2024). The novelty of the research lies in the fact that the most recent publications of this newspaper are studied for the first time using the original domestic software package “Balanced Linguistic Corpus Generator and Corpus Manager”. In the course of the study, a corpus of news texts was automatically collected; some search requests were performed in the corpus by lemma and by part of the token (beginning, middle, ending) — thereby a search method was developed that can be used in similar studies; in the obtained contexts, thematic dominants were identified (refusal to own a car / switching to electric vehicles, lack of money / excessive spending when using cars, crimes, accidents and misfortunes, economic failures / losses / troubles), which have a negative connotation. Positively marked contexts were recorded a few times only. Thus, the reviewed news text predominantly record a negative agenda regarding personal vehicles. It was also concluded that the study has potential in terms of creating databases of evaluative markers taking into account the genre specifics of various texts.
Интеграция ментальных пространств в интернет-мемах
Authors: Рохлина Т.А. 
Published: February 2025

Целью настоящего исследования является изучение особенностей процессов порождения и восприятия интернет-мемов, а также специфики представления знаний в них с точки зрения когнитивно-коммуникативного подхода. Новизна заключается в том, что в данной статье впервые предлагается объяснение взаимодействия ментальных пространств при порождении-восприятии немецкоязычных мемов и дается схема, иллюстрирующая процесс интеграции ментальных пространств в меме с учетом его динамического характера. Мем рассматривается автором как полимодальный дискурс, обладающий динамическим характером, что следует из его способности к репликации и развитию в результате этой репликации. Представлены результаты исследования 100 немецкоязычных интернет-мемов с ресурса Reddit.com за апрель 2024 года. В ходе исследования установлено, что в основе комизма данных произведений лежит полимодальная метафора, объясняется особенность ее функционирования в меме.
The purpose of this paper is to study the features of generation and perception processes of Internet memes, as well as the specifics of knowledge representation in them in terms of a cognitive and communicative approach. The novelty lies in the fact that the author for the first time explains mental spaces interaction in the generation-perception process of German-language memes and proposes a diagram illustrating the mental spaces integration in memes, taking into account their dynamic nature. The author considers the meme as a multimodal discourse with a dynamic character, which follows from its ability to replicate and develop while replicating. The results of a study of 100 German-language Internet memes from the resource Reddit.com in April 2024 are provided. In the course of the study, it was found that the comic character of these works is based on a multimodal metaphor, and the author explains the peculiarity of its functioning in a meme.