bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of some new 3‐pyrazolyl‐substituted‐4(3H)quinazolinones
Authors: Plescia Salvatore , Daidone Giuseppe , Dattolo Gaetano , Aiello Enrico 
Published: April 2009

AbstractN‐(1‐Phenyl‐3‐methylpyrazol‐5‐yl)‐o‐aminobenzamide reacted with orthoesters to yield some new 3‐pyrazolyl‐substituted‐4(3H)quinazolinones (VIIa,b,c,d). An alternative synthesis of Vllb was accomplished by reaction of acetylanthranyl with l‐phenyl‐3‐methyl‐5‐aminopyrazole.
A convenient synthesis of 2‐aminopyridine‐3‐carbonitriies
Authors: Kurihara Hideshi , Mishima Hiroshi 
Published: April 2009

AbstractThe 5‐ and/or 6‐alkyl substituted derivatives of 2‐aminopyridine‐3‐carbonitrile were synthesized via dienamine intermediates (3) produced by the addition‐elimination reaction of various enamines to methoxymethylene malondinitrile. The reaction can be carried out without the isolation of the dienamine intermediates.
A malonic ester‐type synthesis with 4‐chloroquinoline utilizing highly acidic enols
Authors: Scoville Ann , Smith Francis X. 
Published: April 2009

AbstractA synthetic method of attaching carbon‐chain substituents to the 4‐position of the quinoline ring was developed. In our approach enolate anions were generated from highly acidic enols under conditions in which the 4‐chloroquinoline can be N‐acylated or N‐protonated. Isopropylidene alkyl(4‐quinolyl)malonates or 5‐alkyl‐5‐(4‐quinolyl)barbituric acids were obtained from the reaction of 4‐chloroquinolines with isopropylidene alkylmalonates in acetic anhydride or with 5‐alkylbarbituric acids by heating in the absence of solvent. Some of the products were hy‐drolyzed and decarboxylated to give the corresponding 4‐alkylated quinolines.
The reaction of aroylhydrazines with N‐phenylsulfonylarenehydrazonoyl chlorides. A route to substituted 4‐amino‐(4H)‐1,2,4‐triazoles and 1,3,4‐oxadiazoles
Authors: Shawali Ahmad S. , Fahmi Abdel‐Gawad A. 
Published: April 2009

AbstractTreatment of N‐phenylsulfonylarenehydrazonoyl chlorides (II) with equivalent amounts of aroylhydrazines (III) in ethanol gave 3,5‐diaryl‐4‐phenylsulfonylamino‐1,2,4‐triazoles (IV). Reaction of II with two equivalents of III in tetrahydrofuran gave 2,5‐diaryl‐1,3,4‐oxadiazoles (V), in addition to IV. Addition of triethylamine to II or its mixture with III yielded only the tetrazenes (VIII). The possible pathways leading to IV‐V and VIII are discussed. J. Chem. Soc., 14, 1089 (1977)
A new facile synthesis of 5‐arninopyridazine‐4‐carboxylic acid
Authors: Chimichi S. , Nesi R. 
Published: April 2009

AbstractHofmann rearrangement of 5‐carbamylpyridazine‐4‐carboxylic acid (6), obtained from pyrida‐zine‐4,5‐dicarboxylic acid (3) through the corresponding anhydride (5), afforded 5‐aminopyrida‐zine‐4‐carboxylic acid (1) in good yield. Compound 1 cyclised with benzoyl chloride in pyridine to give 2‐phenylpyridazino[4,5‐d]‐1,3‐oxazin‐4‐one (7), a new heterocyclic ring system. J. Heterocyclic Chem., 14, 1099 (1977)
Synthesis of 3‐methyl‐[1,2,4] ‐triazepino[6,5,4‐jk] carbazol‐4(3H)one
Authors: Peet Norton P. , Sunder Shyam 
Published: April 2009

AbstractThe title compound (14), a representative of a novel ring system, was prepared from 9H‐carbazole‐1‐carboxylic acid 1‐methylhydrazide (7) and triethyl orthoformate. Attempted cyclization of 7 with triethyl orthoacetate led only to 9H‐carbazole‐l‐carboxylic acid 2‐(l‐ethoxyethylidene)‐l‐methylhydrazide (16). Treatment of 16 with trifluoroacetic acid gave 9H‐carbazole‐1‐carboxylic acid (12). A postulated mechanism for this transformation was supported by studies with model compounds. A new synthesis of 1‐benzoyl‐2‐methylhydrazine (24), using 1‐acetyl‐1‐methylhydrazine (22) as a synthon, is described.
Quinazolines and 1,4‐benzodiazepines LXXIX. 8‐nitro‐pyrazolo[1,5‐a]‐[1,4] benzodiazepines
Authors: Gilman Norman W. , Fryer R. Ian 
Published: April 2009

AbstractThe preparation of 8‐nitro substituted pyrazolobenzodiazepines from 2‐fluoro‐5‐nitrobenzo‐phenone (1) and 3,5‐diacetoxymethylpyrazole (2) is reported.
Comparison between triplet and singlet molecular oxygen oxidation of fully substituted alkoxyoxazoles
Authors: Graziano M. L. , Carotenuto A. T. , Iesce M. R. , Scarpati R. 
Published: April 2009

AbstractOxidation by ground‐state molecular oxygen of fully substituted alkoxyoxazoles I gave imines IV as major products; diacylcarbamates III were also obtained as minor products. The free radical nature of the autoxidation was established. A mechanistic interpretation of the results is suggested also in the light of the results of the oxidation with singlet oxygen.
3‐Azido‐1,2,4‐triazine N‐Oxides. Syntheses and structure elucidation
Authors: Goodman Mark M. , Paudler William W. 
Published: April 2009

AbstractSeveral 3‐azido‐1,2,4‐triazine 1‐oxides were prepared by treating the appropriate 3‐hy‐drazino derivatives with nitrous acid. 3‐Azido‐1,2,4‐triazine 2‐oxide was prepared by reaching the corresponding 3‐bromo derivative with either tetramethylguanidinium azide in chloroform or sodium azide in aqueous acetone. The azido derivatives which could cyclize to form the tetra‐zolo isomers were proven to exist enitrely in the open chain form by a 13C nmr, 1H nmr and infrared spectroscopic study.
Central nervous system depressants. 14. As‐triazino‐1,4‐benzodiazepines
Authors: Moffett Robert Bruce , Evenson Gerald N. , Von Voigtlander P. F. 
Published: April 2009

AbstractSeven series of as‐triazino[4,3‐a] [1,4]benzodiazepines were prepared which differed in the degree of unsaturation or the nature and position of oxygen function on the triazino ring. These were prepared by closing the triazino ring of appropriately substituted hydrazones from 2‐hydrazinobenzodiazepines or by condensing substituted hydrazines with 2‐thiobenzodiazepines. Most of these represent new ring systems. They were tested in a battery of tests designed to uncover central nervous system activities. Most of the activity was found in tests thought to be indicative of anxiolytic, hypnotic or sedative potential. Five of the series contained members more active than the standard, diazepam, and a few of the compounds were among the most potent benzodiazepines known. Some of the intermediate benzodiazepine hydrazones were also active.
Reactions of methylpyrylium, thiapyrylium, and flavylium salts with tetracyanoethylene
Authors: Haley N. F. 
Published: April 2009

AbstractThe reaction of 2‐ or 4‐methyl‐2,6‐diphenylpyrylium perchlorate with tetracyanoethylene (TCNE) in pyridine gives 2‐ or 4‐(2,3,3‐tricyanopropylidene)‐2,6‐diphenylpyran in good yield. Similar results are obtained from 2‐ or 4‐methyl‐2,6‐diphenylthiapyrylium and 4‐methylflavylium perchlorates. In one case a stable charge‐transfer salt is isolated from the reaction of a methylene base and TCNE. The reaction mechanism of dye formation is discussed.
Chemistry of the phenoxathiins II. Synthesis of 1‐azaphenoxathiin
Authors: Martin G. E. , Turley J. C. , Williams L. 
Published: April 2009

AbstractThe synthesis of 1‐azaphenoxathiin, the parent ring system of a recently reported class of novel CNS agents is described. The 13C‐nmr spectrum and its assignment are also reported as a model for structure confirmation studies.
Synthesis of 1,5‐dideazariboflavin
Authors: Weinstock Louis T. , Wiegand C. J. Wesley , Cheng C. C. 
Published: April 2009

Abstract1,5‐Dideazariboflavin, an analog of riboflavin containing the original conjugated double bond system between positions 1 and 5, was synthesized by the condensation of 4,5‐dimethyl‐ N‐ribitylanthranilaldehyde and the sodium salt of 2,4,6‐piperidinetrione.
Synthèse d'hydroxyspirocétals insaturés et hétérocyclisation en méthyl‐5 trioxa‐2,6,11 tricyclo[5.3.1.01.5]undécane
Authors: Cottier Louis , Descotes Gérard 
Published: April 2009

AbstractL'irradiation photochimique de cétoacétals insaturés 4 conduit à des hydroxyspirocétals insaturés isomères 6 qui évoluent par hétérocyclisation en polyéther tricyclique de type 7.
Alkylation de la dimethyl‐5 5′ isoxazolidinone‐3 en catalyse par transfert de phase
Authors: Ly Bunkuoy , Dou Henri J. M. , Hassanaly Mme Parina , Verducci Jean 
Published: April 2009

AbstractL'alkylation en catalyse par transfert de phase d'anions ambidents du type N‐C‐O− conduit à un mélange de composés O et N substitués. Les pourcentages de O substitution sont de Fordre de 20% avec des halogénures primaires, et de 35% avec des halogénures secondaires. Le rendement total de la réaction est de 60% en moyenne.
Synthesis of 7‐oxo‐8‐aza‐10a‐homoprost‐13‐enoic acid
Authors: Zoretic Phillip A. , Shiah T. 
Published: April 2009

AbstractThe synthesis of a prostaglandin E1 analog, 7‐oxo‐8‐aza‐10a‐homoprost‐13‐enoic acid, is reported.
Etude de l'équilibre azido ⇌ tétrazole dans la séric du thiazolo[2,3‐e]‐tétrazole. III. Effects des substituants
Authors: Faure Robert , Galy Jean‐Pierre , Vincent Emile‐Jean , Elguero José 
Published: April 2009

AbstractLes effets de substituant sur l'équilibre azido/tétrazole ont été étudiés par résonance magnétique du proton dans deux solvants deutériés (chloroforme et diméthylsulfoxyde) dans le cas des azidothiazoles, benzothiazoles, thiadiazoles et isoxazoles. Pour les dérivés du thiazole, on trouve une excellente relation de Hammett, aussi bien pour les substituants en position 4 qu'en position 5.
Nucléosides de synthèse XIV. Du choix des paramètres réactionnels pour l'obtention préférentielle de nucleosides en série benzoazole par réaction de fusion
Authors: Barascut Jean‐Louis , Kam Bernard L. , Imbach Jean‐Louis 
Published: April 2009

AbstractGrǎce au choix de certains paramétres réactionnels, de la réaction de (usion acido‐catalysée, notamment du pourcentage de catalyseur, nous avons synthétisé divers nucléosides des séries benzotriazole et benzimidazole. Cette approche nous a permis d'obtenir pour la première fois les nucléosides N‐2 substitués ainsi que les anomères α substitutés en N‐1 correspondant à ces aglycones. Nous avons ainsi montré qu'il était possible d'augmenter la sélectivité de la réaction de fusion acido‐catalysée.
Synthesis of the thia‐analog of angustidine, angustoline, naucléfine and nauéletine
Authors: Shafiee A. , Rashidbaigi A. 
Published: April 2009

AbstractCondensation of 1‐methyl‐3,4‐dihydrobenzo[b]thieno[2,3‐c]pyridine (6) with nicotinic acid in the presence of ynamine (12) gave 2‐nicotinyl‐1,2,3,4‐tetrahydro‐1‐methylenebenzo[6]thicno‐|2,3‐c]pyridine (13). Photocyclization of the enamide (13) afforded thia‐analog of naueléfine (15). Thia‐analogs of angustidine (19), and nauclétine (27) were prepared similary through photocyclization of the enamides 18 and 26, respectively. Reduction of 27 with sodium boro‐hydride gave thia‐analog of angustoline (29).
Catalysis in aromatic nucleophilic substitution. Note II. Piperidino substitution reactions of some 2‐l‐3‐nitrothiophenes and 2‐l‐5‐nitrothiophenes in methanol and benzene
Authors: Spinelli Domenico , Consiglio Giovanni , Noto Renato 
Published: April 2009

AbstractThe rates of piperidino substitution of some 2‐L‐3‐nitrothiophenes (I) and 2‐L‐5‐nitrothiophenes (II) (L = Cl, Br, I, OC6H4NO2‐p, and SO2Ph) have been measured in methanol and in benzene at various piperidine concentrations. The reactivity of compounds (I) is not affected by the piperidine concentration in both methanol and benzene, except for the case of L = I (Ic). Probably due to association effects, the reactivity of Ic in benzene decreases as the piperidine concentration is increased. The reactions of compounds II follow overall second order kinetics in methanol while in benzene a different behaviour is observed as a function of the nature of the leaving group. In fact, the piperidino substitutions of IIa‐c (L = Cl, Br, I) are mildly accelerated at high piperidine concentrations (a moderate solvent effect); on the contrary the reactivity of IId and e shows a strong dependence on the piperidine concentration, pointing out a genuine base catalysis.
Studies on the synthesis of heterocyclic compounds. III. Synthesis of 1,3,2‐benzodioxa‐ and 1,3,2‐benzoxathiarsole derivatives
Authors: Anchisi Carlo , Corda Luciana , Maccioni Antonio , Podda Gianni , Cabiddu Salvatore 
Published: April 2009

AbstractThe preparation and reaction of 1,3,2‐benzodioxa‐ and 1,3,2‐benzoxathiarsoles (IIa‐b) are described. Spiran derivatives Va‐c are obtained by treating IIa‐b with Ia‐b and triethylamine, while the reaction of IIa‐b with sodium hydroxide, ethoxide and p‐cresolate gives the compounds VIa‐b, VIIa‐b and VIIIa‐b, that can evolve to Xa‐b. Reaction of IIa‐b with sodium p‐toluenethio‐late and n‐butyllithium gave the compounds IXa‐b and XIa‐b respectively. The structure of the prepared compounds has been determined by elemental analysis and spectroscopic data.
A PMR conformational study of some (E)‐α‐nitro‐β‐arylstyrenes
Authors: Arcoria A. , Bottino F. A. , Sciotto D. 
Published: April 2009

AbstractThe 60 MHz room temperature pmr data of some α‐nitro‐β‐arylstyrenes are used to assign the stereochemical configuration. The variable temperature pmr spectra exclude the presence of a rotational isomerism. The preferred conformation are then established by analysis of the chemical shifts of the heterocyclic protons.
The oxidative coupling of indole with some phenolic compounds, naphthols and catechols
Authors: Omote Yoshimori , Takizawa Yasuomi , Mochida Shunichi , Tsuda Yoshihiko , Sugiyama Noboru 
Published: April 2009

AbstractThe oxidative coupling of indole with three naphthols, 2‐naphthol, 2,3‐dihydroxynaphthalene and 2,7‐dihydroxynaphthalene gave 1,1‐bis(3′‐indolyl)‐2(1H)naphthalenone, 1,1‐bis(3′‐indolyl)‐3‐hydroxy‐2(1H)naphthalenone and 1,1‐bis(3′‐indolyl)‐7‐hydroxy‐2(1H)naphthalenone, respectively. The coupling of indole with protocatechuic aldehyde gave bis‐(3‐indolyl)‐(3′,4′‐di‐hydroxyphenyl)methane and that of indole with homocatechol gave 3‐(2′‐methyl‐3′,4′‐di‐hydroxyphenyl)indole.
Pseudo‐phenalenone und pseudophenaleniumsalze sowie ihre reaktionen
Authors: Neidlein R. , Kraemer A. D. 
Published: April 2009

AbstractThe reactivity of the thiapseudophenalenone (1, 2‐phenyl‐5H‐naphtho[1,8‐bc]thiophen‐5‐one) and of the thiapseudophenalenium salt (2, 2‐phenyl‐5‐ethoxynaphtho[1,8‐bc]thioliumtetra‐fluoroborate) towards N‐nucleophilic compounds R‐NH2 was of interest. We obtained the substituted iminothiapseudophenalenones (3a‐3i, 4). With C‐nucleophilic reactants we isolated 4a, 4b, 8‐11 and with 2,3,4,5‐tetrachlorocyclopentadiene we obtained thiapentapseudophena‐fulvalene (7).
The reaction of 2,6‐diphenyl‐2,3,5,6‐tetrahydro‐4H‐thiopyran‐4‐one with sulfuryl chloride
Authors: Van Allan J. A. , Reynolds G. A. , Chen C. H. 
Published: April 2009

Abstract2,6‐Diphenyl‐2,3,5,6‐tetrahydro‐4H‐thiopyran‐4‐one was treated with one, two, and three equivalents of sulfuryl chloride in the presence of pyridine to give the dihydrothiopyranone 2, the 3‐chlorodihydrothiopyranone 3, and the triehlorotetrahydrothiopyranone 4, respectively. Compound 4 was converted to 3‐chloro‐2,6‐diphenyl‐4H‐thiopyran‐4‐one by pyrolysis and to 3‐hydroxy‐2,6‐diphenyl‐4H‐thiopyran‐4‐one on treatment with alcohols. Several pyrylium dyes were prepared from the latter compounds.
Three convenient and novel syntheses of 4‐amino‐2‐arylpyrimidines
Authors: Singh Baldev , Lesher George Y. 
Published: April 2009

Abstract4‐Amino‐2‐arylpyrimidines can be prepared conveniently by the reaction of an amidine with the readily available 3‐ethoxyacrylonitrile, 2‐chloroacrylonitrile or 2‐(1‐piperidinyl‐methyl)acrylonitrile.
Diels‐alder reactions of pyrroles as an entry to substituted 3‐oxatropanes and tetrasubstituted pyrrolidines
Authors: Donnini C. Paul , Just George 
Published: April 2009

AbstractThe Diels‐Alder adduct of N‐(p‐toluenesulfonamido)pyrrole and dimethyl acetylenedi‐carboxylate, 2,3‐dimethyl N‐(p‐toluenesulfonamido)‐7‐azabieyclo[2.2.1]‐2,5‐heptadiene‐2,3‐di‐carboxylate (1c), was obtained in good yield and converted to remarkably stable 3‐oxatropanes (6 and 8) in 25% yield.
Synthesis of pyridyloxadiazoles 1. Characterization and thermal rearrangement of an unexpected 1,2,4‐oxadiazol‐5(4H)one
Authors: Marquez Victor E. , Diparsia Maria T. , Kelley James A. 
Published: April 2009

AbstractThe synthesis of pyridyloxadiazoles by the reaction of acid chlorides with 5‐(2‐pyrklyl)‐tetrazole or 2‐pyridineamidoxime was studied. Reaction of 2‐pyridineamidoxime with N,N‐dimethylcarbamyl chloride produced 3‐(2‐pyridyl)‐4‐N,N‐dimethylaminocarbony 1‐1,2,4‐oxadi‐azol‐5(4H)one instead of the expected oxadiazole. The oxadiazolone underwent thermal rearrangement with expulsion of carbon dioxide to yield the desired 3‐(2‐pyridyl)‐5‐N,N‐dimethylamino‐1,2,4‐oxadiazole.
Reactivity of the A‐CH=N‐NR‐CX‐B system. 4‐R‐5‐hydroxy‐5‐phenyl‐2,3,4,5‐letrahydro‐1,2,4‐triazine‐3‐thiones
Authors: Werber Giuseppe , Buccheri Francesco , Vivona Nicolb , Gentile Manila 
Published: April 2009

AbstractThe behaviour of phenylglyoxal thiosemicarbazones towards aqueous sodium hydroxide have been studied. Examples of addition compounds, 5‐hydroxy‐5‐phenyl‐2,3,4,5‐tetrahydro‐1,2,4‐triazine‐3‐thiones, are reported.
The synthesis of 2‐phenyl‐5H‐imidazo[2,1‐a] [2,4]benzodiazepines
Authors: Fryer R. Ian , Earley James V. 
Published: April 2009

AbstractA one step synthesis of 2‐phenyl‐5H‐irnidazo[2,1‐a][2,4]benzodiazepines (4) from 2‐(2‐imidazolyl)benzophenones (3) is reported. Oximation and reduction of the benzophenone, 3a led to the benzhydrylamine derivative 7 which was cyclized to differently substituted 6,7‐di‐hydroimidazo[2,1‐a][2,4]benzodiazepines depending on the reactant chosen.
Quaternary salts from 2‐(methylpyridyl or quinolyl)benz‐X‐azoles and related polymethine dyes
Authors: Barni Ermanno , Savarino Piero 
Published: April 2009

AbstractThe quaternisation of 2‐(methylpyridyl or quinolyl)benz‐X‐azoles mainly leads to the corresponding pyridinium and quinolinium salts, from which polymethine dyes are prepared. The electronic spectra and the methyl protons chemical shifts are briefly discussed.
Stéroidohétérocycles: Hétérocycles azotés a 5,6 et 7 chainons accolés simultanément aux cycles A et B d'un stéroide par les positions 4,5 et 6
Authors: Daunis Jacques , Del Vecchio Gérard , Jacquier Robert , Lopez Hélène , Maury Georges 
Published: April 2009

AbstractDe nouveaux systèmes formés d'un hétérocycle azoté à cinq, six ou sept chaînons (pyrazole, pyrimidine ou diazépine) accolé simultanément aux deux cycles A et B d'un dérivé du cholestane par les positions 4, 5 et 6 ont été préparés.
Synthesis of 6‐chlorofuro[2,3‐b]pyridine‐2‐carboxylie acid
Authors: Weis C. D. 
Published: April 2009

AbstractA new route was employed to synthesize methyl 6‐ehlorofuro[2,8‐b]pyridine‐2‐earboxylate by eoneurrent dehydrohalogenation and dehydration of 3‐ehloro‐3‐(β,β‐dichloro‐β‐ethoxycar‐bonylelhyl)‐2,6‐piperidinedione using methyl phosphonyl chloride.
Unimolecular reaction sequence in the electron impact induced fragmentation of some methylenoxazolidinones
Authors: Giannetto Placido , Sindona Giovanni , Uccella Nicola 
Published: April 2009

AbstractThe unimolecular processes of some methylenoxazolidinones bombarded in the gas phase by electrons have been investigated by MIKE analysis, precise mass measurements and isotopic labelling studies. The overall delocalisation effect of the substitution on the nitrogen contained has been ascertained through the study of the reaction mechanism and of the possible reacting ionic structures.
A synthesis of 6,11‐dihydro‐2‐methyl‐6H‐pyrimido[2,1‐b]quinazolin‐4‐ones
Authors: Friary R. 
Published: April 2009

AbstractReductive cyclization of 2‐methylthio‐1‐(2‐nitrobenzyl)‐6‐pyrimidones with stannous chloride and acetic acid in methanol gives 6,11‐dihydro‐6H‐pyrimido[2,1‐b]quinazolin‐4‐ones, and, with trialkylphosphites, 6,11‐dihydro‐11‐alkylpyrimido[2,1‐b]quinazolin‐4‐ones.
Bromine‐induced cyclization of 1‐acyl‐3‐(3‐thienyl)‐2‐thioureas to 2‐acylaminothieno[3,2‐d]thiazoles
Authors: Grehn Leif 
Published: April 2009

AbstractThree different 1‐acyl‐3‐(3‐thienyl)‐2‐thioureas were cyclized to 2‐acylaminothieno[3,2‐d]thiazoles with bromine in acetic acid whereas the corresponding 2‐thienylthiourea derivatives were brominated under the same reaction conditions. The parent thieno[3,2‐d]thiazole was prepared by acid hydrolysis and deamination of 2‐benzoylaminothieno[3,2‐d]thiazole. This new heterocyclic compound was nitrated and brominated in the 5‐position.
N‐Vinyl as N‐H protecting group. Synthesis of cyclic imines from N‐vinyllactams and organolithium reagents
Authors: Bielawski Jacek , Brandänge Svante , Lindblom Lars 
Published: April 2009

AbstractOn reaction with organolithium reagents followed by hydrolysis and distillation, N‐vinylpyrrolidone (1) gives five‐membered ring imines 3‐8, whereas N‐vinylcaprolactam (2) gives mixtures of seven‐membered ring imines and the corresponding ∈‐amino ketones.
Synthesis via pummerer intermediates. III. Rearrangements of 3‐(methylsulfinyl)quinolinones, 3‐(methylsulfinyl)cinnolinones, 3‐(methylsulfinyl)chromanones and 3‐(methylsulfinyl)chromones with acetic anhydride and with thionyl chloride
Authors: Connor David T. , Young Patricia A. , von Strandtmann Maximillian 
Published: April 2009

AbstractThe reaction of 1‐methyl‐3‐(methylsulfinyl)‐4(1H)quinolinone (1) with acetic anhydride and thionyl chloride gave 3‐[[(acetyloxy)methyl]thio]]‐1‐methyl‐4(1H)quinolinone (2) and 3‐[(chloromethyl)thio]‐1‐methyl‐4(1H)quinolinone (3) respectively. 3‐(Methylsulfinyl)‐4(1H)cinnolinone (4) gave the corresponding products when treated under similar conditions. Treatment of 8‐methoxy‐3‐(methylsulfinyl)‐4H‐1‐benzopyran‐4‐one (11) with acetic anhydride and thionyl chloride gave bis addition vinyl Pummerer products 2,3‐bis(acetyloxy)‐2,3‐dihydro‐8‐methoxy‐3‐(methylthio)‐4H‐1‐benzopyran‐4‐one (12) and 2,3‐dichloro‐2,3‐dihydro‐8‐methoxy‐3‐(methylthio)‐4H‐1‐benzopyran‐4‐one (13), respectively.
Synthesis of an imidazo[1,2‐c]pyrimidine analog of a thiamine antagonist coccidiostat and a comparison of several methods for the preparation of imidazo[1,2‐c]pyrimidines
Authors: Kluge Arthur F. 
Published: April 2009

AbstractSeveral methods for the preparation of imidazo[1,2‐c]pyrimidines are presented. Compound 12 was prepared from 11 and chloroacetaldehyde in water using a buffer to control pH. Compound 12 was converted in two steps to 14, the etheno bridged analog of the coccidiostat 1. Several methods were used to prepare 8‐phenylimidazo[1,2‐c]pyrimidine (16). In terms of yield the best method was the reaction of the aminopyrimidine 15 with chloroacetaldehyde in acetone and in the presence of calcium carbonate as an acid scavenger. Reaction of the 4‐chloro‐pyrimidine 19 with aminoacetaldehyde diethyl acetal gave 16 directly in modest yield.
The synthesis of the 1‐ and 2‐cycloalkyl‐1,2,3‐benzotriazole system
Authors: Serve' M. Paul , Seybold P. G. , Covault H. Patrick 
Published: April 2009

AbstractThe first reported synthesis of 1‐ and 2‐cycloalkyl‐1,2,3‐benzotriazoles is reported. Physical and spectral data of the system are reported. Molecular orbital calculations on the 1,2,3‐benzotriazole anion show that N1 is a more nucleophilic site than N2.
Synthesis of 3‐N‐acetyl‐N‐arylaminoacetyl‐4‐ethoxycarbonyl‐5‐methylpyrazoles
Authors: Chantegrel Bernard , Gelin Suzanne 
Published: April 2009

AbstractThe acetylation of 2‐N‐arylaminomethylene‐4‐ethoxycarbonyl(or acetyl)‐5‐melhyl‐3(2H)furan‐ones produces N‐acetylated compounds which react with hydrazine to yield substituted pyrazoles.
Condensed benzopyrans II. Some derivatives of 3H‐pyrano[3,2‐f]quinoline
Authors: Khan Misbahul Ain , Gemal André Luis 
Published: April 2009

AbstractThe reaction of 6‐aminoeoumarin with some ethoxymethylene compounds and dimethyl acetylenedicarboxylate led to condensation products which on thermal cyclizations afford new derivatives of 3H‐pyrano[3,2‐f]quinoline (IIa‐IIc).