bluuebunny/crossref_metadata_2025_split huggingface dataset:
Information requirements for sustainable consumption
Authors: Seifi Shahla , Zulkifli Norzima , Yusuff Rosnah , Sullaiman Shamsuddin 
Published: July 2012

PurposeAn increasingly important factor that influences purchasing decisions is that of environmental protection, particularly associated with climate change. This is particularly important as far as the purchase of consumer durables is concerned because of the energy that they consume; energy efficiency is one route towards minimizing environmental impact. Minimizing such impact is one factor towards achieving sustainability and therefore making possible sustainable development. This paper aims to address this issue.Design/methodology/approachThis paper shows that labeling is a crucial component of sustainable purchasing. It is based on literature and a review of current practice in various countries around the world.FindingsThe central argument of this paper is that the desire to make sustainable purchasing decisions necessitates better information to make decisions according to this criterion. This in turn requires manufacturers to provide better information through their labeling.Social implicationsThe paper shows that better information enables more sustainable consumer purchasing decisions.Originality/valueThis research extends knowledge of the components of sustainability and requirements for sustainable development, particularly as far as consumer purchasing decisions are concerned. It also has potentially important implications for manufacturers and also shows for them an important route towards achieving sustainable development for themselves and for the global economy.
The roles of personal innovativeness and push vs pull delivery methods in travel‐oriented location‐based marketing services
Authors: Beldona Srikanth , Lin Kunwei , Yoo Joanne 
Published: July 2012

PurposeAs mobile devices amass greater capabilities that include broadband internet and global positioning systems (GPS), the relevance of location based marketing (LBM) services has gained increased attention among tourism researchers and marketers alike. The purpose of this paper is to examine the impact of personal travel innovativeness, information privacy and the type of delivery method (pull vs push) on the perception of potential value in LBM programs.Design/methodology/approachData were collected from travelers at two large airports in the USA. A 2*2 design that comprised LBM (services vs promotions) and the delivery method (pull vs push) combined with two primary covariates, namely personal travel innovativeness and information privacy, evaluated the potential value of LBM programs amongst consumers.FindingsThe findings indicate that personal travel innovativeness has a significant impact on the perception of potential value in LBM. Additionally, the pull delivery method was more amenable to customers when compared with the push delivery method.Research limitations/implicationsThere are significant implications for practitioners in the way LBM programs can be conceived and implemented. Also, marketing messages can be produced based on the relevance of the findings.Originality/valueThe paper is the first to directly ascertain the impact of the delivery method and travel innovativeness in an emerging domain of LBM using a synthesis of constructs.
Self‐declared sensitive skin in China: a community‐based study in three top metropolises
Authors: Xu F. , Yan S. , Wu M. , Li F. , Sun Q. , Lai W. , Shen X. , Rahhali N. , Taieb C. , Xu J. 
Published: July 2012

AbstractObjectives  To investigate the prevalence and the factors related to the sensitive skin in China.Methods  A community‐based study was undertaken in three major cities in China, Beijing, Shanghai and Guangzhou, from November 2009 to January 2010. The participants in the study were screened by cluster sampling, and were investigated by interview at their own homes. A questionnaire, including skin sensitivity, the occurrence of burning, prickling or irritating sensations correlated with the factors, history of skin diseases and skin types, was given to each participant aged over 15 years.Results  Totally 9154 questionnaires were completed (3931 men and 5223 women). The mean prevalence of very sensitive and sensitive skin in three cities was 13% (17.12% in Beijing, 9.10% in Shanghai and 22.39% in Guangzhou.) The mean prevalence was 8.62% in men and 15.93% in women, with significant difference between men and women in three selected cities (P < 0.001). The total prevalence of very sensitive and sensitive skin was 16.44% in <25 years group, 14.14% in 25–49 years group and 9.73% in ≥50 years group. Moreover, 18.54% of participants claimed with dry skin, 16.70% with greasy skin and 8.04% with normal skin claimed to have the symptoms of sensitive skin.Conclusions  The prevalence of sensitive skin in the three cities of China is much lower than that in Europe and the United States. There was significant difference of the prevalence of sensitive skin among three cities located in different climatic and latitude regions and between men and women. The prevalence gradually decreased with the increasing age. The skin sensitivity was associated to the positive history of atopic dermatitis.
Beneficial effects of the melanocortin analogue Nle4‐D‐Phe7‐α‐MSH in acne vulgaris
Authors: Böhm M. , Ehrchen J. , Luger T.A. 
Published: July 2012

AbstractBackground  α‐Melanocyte‐stimulating hormone (α‐MSH) is a melanocortin peptide that increases skin pigmentation during ultraviolet light‐mediated tanning. As α‐MSH has been shown to possess anti‐inflammatory effects, we assessed the clinical potential of a superpotent α‐MSH analogue, afamelanotide (Nle4‐d‐Phe7‐α‐MSH), in patients with acne vulgaris, the most common inflammatory skin disorder.Methods  Afamelanotide (16 mg) was given in a phase II open‐label pilot study subcutaneously as a sustained‐release resorbable implant formulation to 3 patients with mild‐to‐moderate facial acne vulgaris. Evaluation included lesion count, adverse effects and patient‐reported outcome. Monitoring of laboratory parameters included differential blood counts, electrolytes, urine analysis, and liver and kidney function tests. Skin melanin density was measured by reflectance spectrophotometry.Results  The total number as well as the number of inflammatory acne lesions declined in all patients 56 days after the first injection of afamelanotide. Life quality as measured by Dermatology Life Quality Index likewise improved in all 3 patients 56 days after the first injection of afamelanotide. There were no adverse effects except mild and short‐term fatigue in one patient. All patients experienced increased pigmentation especially on the face. Clinically relevant changes in laboratory parameters were not detected.Conclusions  Afamelanotide appears to have anti‐inflammatory effects in patients with mild‐to‐moderate acne vulgaris. Future trials are needed to confirm the anti‐inflammatory action of this melanocortin analogue in patients with acne vulgaris.
A Two-Component Regulatory System Controls Autoregulated Serpin Expression in Bifidobacterium breve UCC2003
Authors: Alvarez-Martin Pablo , O'Connell Motherway Mary , Turroni Francesca , Foroni Elena , Ventura Marco , van Sinderen Douwe 
Published: July 2012

ABSTRACT

This work reports on the identification and molecular characterization of a two-component regulatory system (2CRS), encoded by
serRK
, which is believed to control the expression of the

ser
2003

locus in
Bifidobacterium breve
UCC2003. The

ser
2003

locus consists of two genes, Bbr_1319 (
sagA
) and Bbr_1320 (
serU
), which are predicted to encode a hypothetical membrane-associated protein and a serpin-like protein, respectively. The response regulator SerR was shown to bind to the promoter region of

ser
2003

, and the probable recognition sequence of SerR was determined by a combinatorial approach of
in vitro
site-directed mutagenesis coupled to transcriptional fusion and electrophoretic mobility shift assays (EMSAs). The importance of the
serRK
2CRS in the response of
B. breve
to protease-mediated induction was confirmed by generating a
B. breve serR
insertion mutant, which was shown to exhibit altered

ser
2003

transcriptional induction patterns compared to the parent strain, UCC2003. Interestingly, the analysis of a
B. breve serU
mutant revealed that the SerRK signaling pathway appears to include a SerU-dependent autoregulatory loop.
Complete Genome Sequence of Streptococcus salivarius PS4, a Strain Isolated from Human Milk
Authors: Martín Virginia , Maldonado-Barragán Antonio , Jiménez Esther , Ruas-Madiedo Patricia , Fernández Leónides , Rodríguez Juan M. 
Published: July 2012

ABSTRACT

Streptococcus salivarius
is a commensal species commonly found in the human oropharyngeal tract. Some strains of this species have been developed for use as oral probiotics, while others have been associated with a variety of opportunistic human infections. Here, we report the complete sequence of strain PS4, which was isolated from breast milk of a healthy woman.
Effectiveness of soft tissue massage and exercise for the treatment of non-specific shoulder pain: a systematic review with meta-analysis
Authors: van den Dolder Paul Andrew , Ferreira Paulo H , Refshauge Kathryn M 
Published: July 2012

ObjectiveTo determine the effectiveness of exercise and soft tissue massage either in isolation or in combination for the treatment of non-specific shoulder problems.MethodsDatabase searches for articles from 1966 to December 2011 were performed. Studies were eligible if they investigated ‘hands on’ soft tissue massage performed locally to the shoulder or exercises aimed at improving strength, range of motion or coordination; non-surgical painful shoulder disorders; included participants aged 18–80 years and outcomes measured included pain, disability, range of motion, quality of life, work status, global perceived effect, adverse events or recurrence.ResultsTwenty-three papers met the selection criteria representing 20 individual trials. We found low-quality evidence that soft tissue massage was effective for producing moderate improvements in active flexion and abduction range of motion, pain and functional scores compared with no treatment, immediately after the cessation of treatment. Exercise was shown by meta-analysis to produce greater improvements than placebo, minimal or no treatment in reported pain (weighted mean=9.8 of 100, 95% CI 0.6 to 19.0) but these changes were of a magnitude that was less than that considered clinically worthwhile. Exercise did not produce greater improvements in shoulder function than placebo, minimal or no treatment (weighted mean=5.7 of 100, 95% CI −3.3 to 14.7).ConclusionThere is low-quality evidence that soft tissue massage is effective for improving pain, function and range of motion in patients with shoulder pain in the short term. Exercise therapy is effective for producing small improvements in pain but not in function or range of motion.
Outcomes of Restrictive Cardiomyopathy in Childhood and the Influence of Phenotype
Authors: Webber Steven A. , Lipshultz Steven E. , Sleeper Lynn A. , Lu Minmin , Wilkinson James D. , Addonizio Linda J. , Canter Charles E. , Colan Steven D. , Everitt Melanie D. , Jefferies John Lynn , Kantor Paul F. , Lamour Jacqueline M. , Margossian Renee , Pahl Elfriede , Rusconi Paolo G. , Towbin Jeffrey A. 
Published: July 2012

Background—
Restrictive cardiomyopathy (RCM) has been associated with poor prognosis in childhood. The goal of the present analysis was to use the Pediatric Cardiomyopathy Registry to analyze outcomes of childhood RCM, with a focus on the impact of phenotype comparing pure RCM with cases that have additional features of hypertrophic cardiomyopathy (HCM).

Methods and Results—

We analyzed the Pediatric Cardiomyopathy Registry database (1990–2008; N=3375) for cases of RCM. Cases were defined as pure when RCM was the only assigned diagnosis. Additional documentation of HCM at any time was used as the criterion for RCM/HCM phenotype. RCM accounted for 4.5% of cases of cardiomyopathy. In 101 (66%), pure RCM was diagnosed; in 51 (34%), there was a mixed phenotype. Age at diagnosis was not different between groups, but 10% of the pure RCM group was diagnosed in infancy versus 24% of the RCM/HCM group. Freedom from death was comparable between groups with 1-, 2-, and 5-year survival of RCM 82%, 80%, and 68% versus RCM/HCM 77%, 74%, and 68%. Transplant-free survival was 48%, 34%, and 22% and 65%, 53%, and 43%, respectively (
P
=0.011). Independent risk factors at diagnosis for lower transplant-free survival were heart failure (hazard ratio 2.20,
P
=0.005), lower fractional shortening
z
score (hazard ratio 1.12 per 1 SD decrease in
z
score,
P
=0.014), and higher posterior wall thickness in the RCM/HCM group only (hazard ratio 1.32,
P
<0.001). Overall, outcomes were worse than for all other forms of cardiomyopathy.

Conclusions—
Transplant-free survival is poor for RCM in childhood. Survival is independent of phenotype; however, the RCM/HCM phenotype has significantly better transplant-free survival.

Clinical Trials Registration—

URL:
http://www.clinicaltrials.gov
. Unique Identifier: NCT00005391.
Using metagenomic analyses to estimate the consequences of enrichment bias for pathogen detection
Authors: Pettengill James B , McAvoy Eugene , White James R , Allard Marc , Brown Eric , Ottesen Andrea 
Published: July 2012

Abstract

Background
Enriching environmental samples to increase the probability of detection has been standard practice throughout the history of microbiology. However, by its very nature, the process of enrichment creates a biased sample that may have unintended consequences for surveillance or resolving a pathogenic outbreak. With the advent of next-generation sequencing and metagenomic approaches, the possibility now exists to quantify enrichment bias at an unprecedented taxonomic breadth.

Findings
We investigated differences in taxonomic profiles of three enriched and unenriched tomato phyllosphere samples taken from three different tomato fields (n = 18). 16S rRNA gene meteganomes were created for each of the 18 samples using 454/Roche’s pyrosequencing platform, resulting in a total of 165,259 sequences. Significantly different taxonomic profiles and abundances at a number of taxonomic levels were observed between the two treatments. Although as many as 28 putative Salmonella sequences were detected in enriched samples, there was no significant difference in the abundance of Salmonella between enriched and unenriched treatments.

Conclusions
Our results illustrate that the process of enriching greatly alters the taxonomic profile of an environmental sample beyond that of the target organism. We also found evidence suggesting that enrichment may not increase the probability of detecting a target. In conclusion, our results further emphasize the need to develop metagenomics as a validated culture independent method for pathogen detection.
Characterisation of a natural variant of the γ-butyrolactone signalling receptor
Authors: Gottelt Marco , Hesketh Andrew , Bunet Robert , Puri Pranav , Takano Eriko 
Published: July 2012

Abstract

Background
The control of antibiotic production in Streptomyces coelicolor A3(2) involves complicated regulatory networks with multiple regulators controlling the expression of antibiotic biosynthetic pathways. One such regulatory network is that of the γ-butyrolactones, the so-called S. coelicolor butanolide (SCB) system. The γ-butyrolactones in this system serve as signalling molecules and bind to the receptor protein ScbR, releasing the repression of its target genes. The resulting expression changes affect the production of the two pigmented antibiotics Act and Red, as well as the transcription of the cpk antibiotic biosynthesis gene cluster and the synthesis of the γ-butyrolactones themselves.

Results
We identified a natural variant of ScbR in S. coelicolor (ScbRM600) that differs from ScbR in the genome-sequenced strain M145 (ScbRM145) by a single amino acid change, R120S. ScbRM600 is impaired in its DNA binding ability and alters the expression of the pathway-specific regulatory genes of the red and cpk antibiotic biosynthesis gene clusters. Also, expression of the γ-butyrolactone biosynthesis gene scbA and production of the signalling molecules is slightly reduced.

Conclusions
The γ-butyrolactone receptor, ScbR, plays a key role in the SCB regulatory cascade and in determining the onset of the expression of the antibiotic regulatory genes.
Extracorporeal Treatment for Thallium Poisoning
Authors: Ghannoum Marc , Nolin Thomas D. , Goldfarb David S. , Roberts Darren M. , Mactier Robert , Mowry James B. , Dargan Paul I. , MacLaren Robert , Hoegberg Lotte C. , Laliberté Martin , Calello Diane , Kielstein Jan T. , Anseeuw Kurt , Winchester James F. , Burdmann Emmanuel A. , Bunchman Timothy E. , Li Yi , Juurlink David N. , Lavergne Valery , Megarbane Bruno , Gosselin Sophie , Liu Kathleen D. , Hoffman Robert S. 
Published: July 2012

Summary

Background
The EXtracorporeal TReatments In Poisoning (EXTRIP) workgroup was formed to provide recommendations on the use of extracorporeal treatment (ECTR) in poisoning. To test and validate its methods, the workgroup reviewed data for thallium (Tl).

Methods
After an extensive search, the co-chairs reviewed the articles, extracted the data, summarized findings, and proposed structured voting statements following a predetermined format. A two-round modified Delphi method was chosen to reach a consensus on voting statements and RAND/UCLA Appropriateness Method to quantify disagreement. Blinded votes were compiled, returned, and discussed during a conference call. A second vote determined the final recommendations.

Results
Forty-five articles met inclusion criteria. Only case reports and case series were identified, yielding a very low quality of evidence for all recommendations. Data on 74 patients, including 11 who died, were abstracted. The workgroup concluded that Tl is slightly dialyzable and made the following recommendations: ECTR is recommended in severe Tl poisoning (1D). ECTR is indicated if Tl exposure is highly suspected on the basis of history or clinical features (2D) or if the serum Tl concentration is >1.0 mg/L (2D). ECTR should be initiated as soon as possible, ideally within 24–48 hours of Tl exposure (1D), and be continued until the serum Tl concentration is <0.1 mg/L for a minimal duration of 72 hours (2D).

Conclusion
Despite Tl’s low dialyzability and the limited evidence, the workgroup strongly recommended extracorporeal removal in the case of severe Tl poisoning.
Safety and Complications of Percutaneous Kidney Biopsies in 715 Children and 8573 Adults in Norway 1988–2010
Authors: Tøndel Camilla , Vikse Bjørn Egil , Bostad Leif , Svarstad Einar 
Published: July 2012

Summary

Background and objectives
Skepticism about performing renal biopsies is often because of uncertainty regarding risk of complications. The aim of this study was to evaluate safety and relevant complications of renal biopsies in pediatric and adult patients in a large national registry study.

Design, setting, participants, & measurements
Kidney biopsies reported in the Norwegian Kidney Biopsy Registry from 1988 to 2010 were included. Risk factors for major complications (blood transfusion and/or surgical or catheter intervention) were analyzed using logistic regression statistics.

Results
Of the 9288 biopsies included, 715 were from children, and 8573 were from adults (≥18 years). Median age was 49 years (range=2 weeks to 94 years). Gross hematuria appeared after biopsy in 1.9% of the patients; 0.9% of patients needed blood transfusion, and 0.2% of patients needed surgical intervention/catheterization. The frequencies were 1.9%, 0.9%, and 0.2% in adults and 1.7%, 0.1% and 0.1% in children, respectively; 97.9% of the biopsies were without complications. In unadjusted analyses, risk factors for major complications were age>60 years, estimated GFR<60 ml/min per 1.73 m2, systolic hypertension, acute renal failure, and smaller clinical center size (<30 biopsies/yr). Adjusted analyses (adjusted for age and/or estimated GFR) showed higher odds ratios (OR) only for smaller clinical center (OR=1.60 [1.02–2.50]) and low estimated GFR (estimated GFR=30–59 ml/min per 1.73 m2 [OR=4.90 (1.60–14.00)] and estimated GFR<30 ml/min per 1.73 m2 [OR 15.50 (5.60–43.00)]).

Conclusions
Percutaneous renal biopsy is a low-risk procedure in all ages. Reduced estimated GFR and smaller center size are associated with an increased risk of major complications.
Long-term radiosurgery effects in the treatment of temporal lobe epilepsy
Authors: Vale Fernando L. , Bozorg Ali M. , Schoenberg Mike R. , Wong Kondi , Witt Thomas C. 
Published: July 2012

Epilepsy surgery is an effective treatment for medically resistant temporal lobe epilepsy (TLE). To minimize complication rates and potentially improve neuropsychology outcomes, stereotactic radiosurgery (SRS) has been explored as an alternative. Two pilot trials have demonstrated the effectiveness of SRS for the treatment of medically resistant TLE, with seizure-free outcomes for approximately 65% of patients at last follow-up. Despite encouraging results, no conclusive long-term outcomes are available for SRS. This article discusses a single patient who presented with recurrent seizures, worsening headaches, and persistent abnormal MRI findings 7 years and 8 months after SRS.
This 29-year-old woman with a history of medically refractory complex partial seizures since childhood was referred for evaluation. Medical management had failed in this patient. The workup was compatible with left mesial temporal lobe onset, with MRI findings suggestive of mesial temporal sclerosis. In 2003, at the age of 23 years, she underwent Gamma Knife surgery (GKS) targeting the left temporal mesial area with a dose of 24 Gy at the 50% marginal isodose line. After GKS, the patient's seizures decreased in frequency over several months, but auras were persistent. Nine months after treatment, she developed worsening headaches. A follow-up MRI study demonstrated a thick, irregular, enhancing lesion in the medial part of the temporal lobe. She was placed on corticosteroids, with resolution of her headaches.
Her seizures and headaches recurred in March 2010. An MRI study showed a 2.2-cm, ill-defined, enhancing cystic lesion in the left mesial temporal lobe with T2 and FLAIR hyperintensity, which was presumably radiation induced. At that time, the patient opted for left temporal lobe resection to control her seizures. Histological examination showed moderately severe, remote, longstanding sclerosis at the level of the hippocampus. A vascular lesion was identified, and it was most consistent with radiation-induced capillary hemangioma. The entorhinal region was severely damaged, with hemorrhage, necrosis, neuronal loss, astrogliosis, and hemosiderin deposition. There was evidence of radiation vasculopathy.
Radiation-induced lesions after SRS for the treatment of epilepsy are not well documented. Although GKS is a promising technique for the treatment of medically resistant TLE, the ideal candidate is not yet well defined. The selection of the appropriate technical parameters to obtain a desirable functional effect without histological damage to the surrounding neural tissue remains a challenge. This case illustrates the need for long-term follow-up when radiosurgery is used for epilepsy.