bluuebunny/crossref_metadata_2025_split huggingface dataset:
SEXUAL DIFFERENCE AND TRINITARIAN DEATH: CROSS, KENOSIS, AND HIERARCHY IN THE THEO‐DRAMA
Authors: TONSTAD LINN MARIE 
Published: September 2010

AbstractHans Urs von Balthasar's “Theo‐Drama: Theological Dramatic Theory” exhibits a mutual funding of a hierarchical ordering of the relation between “man” and “woman” and a hierarchical ordering of the relation between the Father, the Son, and the Spirit. The two hierarchies explain, illustrate, and support one another. Von Balthasar's oscillation between hierarchy and equality, particularly in the divine case, results in a tortured understanding of personhood where being in relation means handing oneself over to another with the threat of death always present. Von Balthasar's understanding of personhood turns out to be fundamentally masochistic. Further, difference collapses into hierarchy and thus turns out to be no more than repetition in the mode of reception, which then poses a serious challenge to Balthasar's account of divine and human being. Since the point of connection between the two is found in his account of the way inner‐trinitarian relations of origin are extended into the world in the sending of the Son, this is the thesis which needs problematizing. For von Balthasar, the kenotic nature of the inner‐trinitarian processions explains what in the life of God makes the cross possible, but this move ascribes something like suffering and death to the inner life of God in a way that undercuts the fullness of divine love while undergirding a hierarchical understanding of divine relationality.
From bench to bedside – translational research in psoriasis
Authors: Prinz JC 
Published: September 2010

AbstractFor many years, psoriasis was firmly believed to be a disease of epidermal keratinocytes, but now is attributed to a combination of genetic and environmental factors that promote a T‐cell mediated immune response in the skin. Psoriasis is now understood to be a systemic T‐cell mediated autoimmune disease with the innate immune system playing an important role. Progress in understanding the pathogenesis of psoriasis has shown that following a stimulus, dendritic and T cell activation leads to the release of cytokines, chemokines and growth factors that initiate the proliferation and altered differentiation of keratinocytes. These factors subsequently lead to continuous activation of T cells and antigen‐presenting cells, particularly dendritic cells, within the psoriatic plaque. This vicious cycle of psoriasis, in which the cytokines interleukin 12 (IL‐12) and IL‐23 play a pivotal role, is a logical target for biological therapy.
Incidence of tuberculosis infection in psoriatic patients on anti‐TNF therapy: report of a case series with 144 patients
Authors: Sánchez‐Moya AI , Dauden E 
Published: September 2010

AbstractBackground  Worldwide clinical trials and post‐marketing surveillance data have demonstrated an increased incidence of tuberculosis (TB) disease associated with antitumour necrosis factor (anti‐TNF) agents. The majority of these cases are presumed to result from a reactivation of latent disease, while the rate of new infections is unknown. A study was performed to evaluate the incidence of latent tuberculosis infection (LTBI) in psoriatic patients screened for biological therapy in a high‐incidence area, such as Madrid, Spain.Patients and methods  One hundred and forty‐four patients with moderate‐to‐severe psoriasis treated with anti‐TNF agents were recruited. All of them were screened for active TB or LTBI before therapy. The screening included a detailed medical study, physical examination, chest X‐ray, tuberculin skin test (TST) with purified protein derivative and re‐TST.Results  A total of 42 (29%) patients were diagnosed with LTBI based on a positive TST or re‐TST, and/or signs of past TB in the chest X‐ray. All of them received chemoprophylaxis with isoniazide. One patient developed a primary active lymphnode TB.Conclusion  This is the first study to underscore the incidence of LTBI in patients with psoriasis treated with anti‐TNF therapy in the Spanish population. We support that the use of TST is still reliable and an effective diagnostic method for the detection of LTBI in anti‐TNF therapy.
A randomized clinical trial in psoriasis: synchronous balneophototherapy with bathing in Dead Sea salt solution plus narrowband UVB vs. narrowband UVB alone (TOMESA‐study group)
Authors: Klein A , Schiffner R , Schiffner‐Rohe J , Einsele‐Krämer B , Heinlin J , Stolz W , Landthaler M 
Published: September 2010

AbstractBackground  Synchronous balneophototherapy (sBPT) simulates treatment conditions at the Dead Sea for outpatient use. In the past, sBPT proved to be an effective treatment for psoriasis. However, there is a lack of sufficiently large randomized controlled clinical trials evaluating the additional benefit of sBPT compared with ultraviolet B (UVB) monotherapy.Objectives  The purpose of this study was to compare the effectiveness and safety of sBPT with UVB phototherapy (PT) alone in a randomized controlled effectiveness study.Methods  In this phase III, multicentre effectiveness study, 367 patients with moderate to severe psoriasis were randomly allocated in a 1 : 1 ratio to receive either sBPT consisting of narrowband UVB PT with 311 nm and synchronous bathing in 10% Dead Sea salt solution or PT with 311 nm alone. Primary endpoint, analysed on an intention‐to‐treat basis (n = 356), was the relative improvement of the Psoriasis Area and Severity Index (PASI) from baseline to end of treatment (35 sessions or clearance). Sample size calculation aimed at the detection of superiority of at least 10%.Results  Median PASI values were comparable at baseline (sBPT: 15.1, interquartile range: 10.9–24.3; PT: 15.3, interquartile range: 10.0–23.7). A clinically relevant and statistically significant difference of 49.5% between sBPT and PT could be proven at the end of the therapy phase (P < 0.001; Wilcoxon–Mann–Whitney test). Exploratory testing showed a statistically significant superiority of sBPT after 6 months.Conclusions  In routine clinical practice, sBPT is superior to PT alone after 35 treatment sessions and a follow‐up of 6 months. Both treatments demonstrated to be safe.
Renewed focus on the developing human neocortex
Authors: Clowry Gavin , Molnár Zoltán , Rakic Pasko 
Published: September 2010

AbstractMany specifically human psychiatric and neurological conditions have developmental origins. Rodent models are extremely valuable for the investigation of brain development, but cannot provide insight into aspects that are specifically human. The human brain, and particularly the cerebral cortex, has some unique genetic, molecular, cellular and anatomical features, and these need to be further explored. Cortical expansion in human is not just quantitative; there are some novel types of neurons and cytoarchitectonic areas identified by their gene expression, connectivity and functions that do not exist in rodents. Recent research into human brain development has revealed more elaborated neurogenetic compartments, radial and tangential migration, transient cell layers in the subplate, and a greater diversity of early‐generated neurons, including predecessor neurons. Recently there has been a renaissance of the study of human brain development because of these unique differences, made possible by the availability of new techniques. This review gives a flavour of the recent studies stemming from this renewed focus on the developing human brain.
Absence of lymphatic vessels in the dog dental pulp: an immunohistochemical study
Authors: Martin Anna , Gasse Hagen , Staszyk Carsten 
Published: September 2010

AbstractIn spite of numerous investigations it has not been precisely determined whether lymphatic vessels are present in the dental pulp of dogs. Therefore, this study attempted a specific immunohistochemical detection of lymphatic endothelium. The canine teeth of 19 healthy beagle dogs were dissected into three segments (apical, intermediate and occlusal). After decalcification, specimens were embedded in paraffin wax and histologic cross‐sections were stained immunohistochemically using a reliable antibody (anti‐Prox‐1) against the homeobox transcription factor Prox‐1, which is located within the nucleus of lymphatic endothelium. Anti‐Prox‐1 reacted positively with canine control tissues (lymph nodes, gingiva, nasal mucosa), but showed no staining in tissue sections of the dental pulp. The dog dental pulp contained no vascular structures lined with lymphatic endothelium. This suggests that drainage of interstitial fluid makes use of other routes, i.e. extravascular pathways.
Implementing safe motherhood: a low‐cost intervention to improve the management of eclampsia in a referral hospital in Malawi
Authors: Drost E , van Lonkhuijzen LRCW , Meguid T , Landis Lewis D , Zeeman GG 
Published: September 2010

Please cite this paper as: Drost E, van Lonkhuijzen L, Meguid T, Landis Lewis D, Zeeman G. Implementing safe motherhood: a low‐cost intervention to improve the management of eclampsia in a referral hospital in Malawi. BJOG 2010;117:1553–1557.We evaluated the effect of so‐called monitoring and treatment charts on the management of eclampsia in a referral hospital in Malawi. Baseline characteristics, clinical management, as well as overall maternal and perinatal outcome were compared by reviewing the medical files of two groups, before and after introduction of the charts in 2006. The use of the charts has resulted in improved monitoring of women with eclampsia and may have contributed to the reduction in the planned prelabour caesarean section rate from 87% to 33%, as more women underwent induction of labour after stabilisation (P = 0.020). Overall maternal and perinatal outcomes were similar.
Proportion of excision and cervical healing after large loop excision of the transformation zone for cervical intraepithelial neoplasia
Authors: Founta C , Arbyn M , Valasoulis G , Kyrgiou M , Tsili A , Martin‐Hirsch P , Dalkalitsis N , Karakitsos P , Kassanos D , Prendiville W , Loufopoulos A , Paraskevaidis E 
Published: September 2010

Please cite this paper as: Founta C, Arbyn M, Valasoulis G, Kyrgiou M, Tsili A, Martin‐Hirsch P, Dalkalitsis N, Karakitsos P, Kassanos D, Prendiville W, Loufopoulos A, Paraskevaidis E. Proportion of excision and cervical healing after large loop excision of the transformation zone for cervical intraepithelial neoplasia. BJOG 2010;117:1468–1474.Objective  To determine how the proportion of the cervical volume excised affects cervical regeneration.Design  Prospective observational study.Setting  University Hospital.Population  Women planning to undergo excisional treatment for cervical intraepithelial neoplasia who wish to have future pregnancies.Methods  The cervical volume (and dimensions) is calculated with magnetic resonance imaging (MRI) before treatment. The volume (and dimensions) of the cone is assessed before fixation by a volumetric tube and a ruler; the percentage (%) of excision is computed. Cervical regeneration is estimated by repeat MRI at 6 months.Main outcome measures  Cervical regeneration in relation to proportion of excision. Statistical analysis was performed by box plots and analysis of variance.Results  A total of 48 women have been recruited; 29 have completed 6 months follow up. Both the total cervical volume (from MRI) before treatment and the volume of the excised/ablated cone varied substantially. The estimated proportion of excision varied significantly between 4% and 39% (median 11%). Multivariate linear regression revealed that the proportional deficit at 6 months post‐treatment was determined mainly by the proportion of the excised volume.Conclusions  Careful assessment of risks and benefits of treatment is essential when deciding to treat women who wish to have future pregnancies. Assessment of the proportion of the cervical volume and length excised might identify those that need further surveillance during future pregnancy.
An economic analysis of induction of labour and expectant monitoring in women with gestational hypertension or pre‐eclampsia at term (HYPITAT trial)
Authors: Vijgen SMC , Koopmans CM , Opmeer BC , Groen H , Bijlenga D , Aarnoudse JG , Bekedam DJ , van den Berg PP , de Boer K , Burggraaff JM , Bloemenkamp KWM , Drogtrop AP , Franx A , de Groot CJM , Huisjes AJM , Kwee A , van Loon AJ , Lub A , Papatsonis DNM , van der Post JAM , Roumen FJME , Scheepers HCJ , Stigter RH , Willekes C , Mol BWJ , Van Pampus MG ,   for the HYPITAT study group
Published: September 2010

Please cite this paper as:Vijgen S, Koopmans C, Opmeer B, Groen H, Bijlenga D, Aarnoudse J, Bekedam D, van den Berg P, de Boer K, Burggraaff J, Bloemenkamp K, Drogtrop A, Franx A, de Groot C, Huisjes A, Kwee A, van Loon A, Lub A, Papatsonis D, van der Post J, Roumen F, Scheepers H, Stigter R, Willekes C, Mol B, Van Pampus M for the HYPITAT study group. An economic analysis of induction of labour and expectant monitoring in women with gestational hypertension or pre‐eclampsia at term (HYPITAT trial). BJOG 2010;117:1577–1585.Objective To assess the economic consequences of labour induction compared with expectant monitoring in women with gestational hypertension or pre‐eclampsia at term.Design An economic analysis alongside the Hypertension and Pre‐eclampsia Intervention Trial At Term (HYPITAT).Setting Obstetric departments of six university and 32 teaching and district hospitals in the Netherlands.Population Women diagnosed with gestational hypertension or pre‐eclampsia between 36+0and 41+0 weeks of gestation, randomly allocated to either induction of labour or expectant monitoring.Methods A trial‐based cost‐effectiveness analysis was performed from a societal perspective during a 1‐year time horizon.Main outcome measures One‐year costs were estimated and health outcomes were expressed as the prevalence of poor maternal outcome defined as either maternal complications or progression to severe disease.Results The average costs of induction of labour (n = 377) were €7077 versus €7908 for expectant monitoring (n = 379), with an average difference of −€831 (95% CI −€1561 to −€144). This 11% difference predominantly originated from the antepartum period: per woman costs were €1259 for induction versus €2700 for expectant monitoring. During delivery, more costs were generated following induction (€2190) compared with expectant monitoring (€1210). No substantial differences were found in the postpartum, follow‐up and for non‐medical costs.Conclusion In women with gestational hypertension or mild pre‐eclampsia at term, induction of labour is less costly than expectant monitoring because of differences in resource use in the antepartum period. As the trial already demonstrated that induction of labour results in less progression to severe disease without resulting in a higher caesarean section rate, both clinical and economic consequences are in favour of induction of labour in these women.Trial registration The trial has been registered in the clinical trial register as ISRCTN08132825.
Gender‐specific aspects in the clinical presentation of cardiovascular disease
Authors: Leuzzi Chiara , Sangiorgi Giuseppe Massimo , Modena Maria Grazia 
Published: September 2010

AbstractMore than a quarter of a million women die each year in the industrialized countries from cardiovascular diseases (CVD), and current projections indicate that this number will continue to rise with our ageing population. Important sex‐related differences in the prevalence, presentation, management and outcomes of different CVD have discovered in the last two decades of cardiovascular research. Nevertheless, much evidence supporting contemporary recommendations for testing, prevention and treatment of CVD in women is still extrapolated from studies conducted predominantly in men. The compendium of CVD indicates that current research and strategy development must focus on gender‐specific issues to address the societal burden and costs related to these incremental shifts in female gender involvement. Indeed, this significant burden of CVD in women places unique diagnostic, treatment and financial encumbrances on our society that are only further intensified by a lack of public awareness about the disease on the part of patients and clinicians alike. This societal burden of the disease is, in part, related to our poor understanding of gender‐specific pathophysiologic differences in the presentation and prognosis of CVD and the paucity of diagnostic and treatment guidelines tailored to phenotypic differences in women. In this, scenario is of outmost importance to know these differences to provide the best care for female patients, because under‐recognition of CVD in women may contribute to a worse clinical outcome. This review will provide a synopsis of available evidence on gender‐based differences in the initial presentation, pathophysiology and clinical outcomes of women affected by CVD.
THE INFLUENCE OF AGE AND SEX ON CARDIAC, RENAL AND CAUDAL ARTERY CATECHOLAMINE CONTENT IN SPONTANEOUSLY HYPERTENSIVE (SHR) AND WISTAR KYOTO (WKY) RATS
Authors: HOWES L. G. , SUMMERS R. J. , LOUIS W. J. 
Published: September 2010

Noradrenaline (NA), adrenaline (A) and dopamine (DA) levels were measured in the heart, kidney and caudal artery of male and female SHR and WKY rats aged 6, 14 and 28 weeks, and the influence of strain, sex and age on catecholamine content determined.
Levels of A were elevated in all three regions of SHR compared to WKY rats, independent of age and sex. This may represent increased A accumulation in sympathetic nerves resulting from the increased sympatho‐adrenomedullary hyper‐reactivity of the SHR strain.
DA levels were also elevated in the heart and kidney of SHR rats, independent of sex and age.
NA levels were lower in the heart of SHR rats, but this appeared to be partly a consequence of cardiac hypertrophy and partly due to strain differences between older male but not female rats. Thus a simple association between decreased cardiac NA levels and hypertension appeared unlikely.
It is emphasised that further genetic studies of F2 backcross rats would be required to establish an etiological association between these differences in catecholamine levels and differences in blood pressure between the SHR and WKY strains.
THE CHRONIC EFFECTS OF β‐ADRENORECEPTOR ANTAGONISTS ON THE EFFLUX OF TRITIATED NORADRENALINE FROM SYMPATHETIC NERVES OF THE PITHED RAT
Authors: DRAPER A. J. , KENDALL H. E. , REDFERN P. H. 
Published: September 2010

The effect of chronic administration of two β‐adrenoreceptor blocking drugs, propranolol and timolol, on transmitter noradrenaline release from sympathetic nerves has been investigatedin vivousing the pithed rat preparation.Oral treatment for 4 weeks with either propranolol (46.3 mg/kg/day) or timolol (7.1 mg/kg/day) significantly raised the stimulation frequency threshold for release of radioactivity on stimulation of the whole spinal outflow of the pithed rat after i.v. injection of3H‐NA.No differences in the stimulation‐evoked rise in mean arterial pressure were observed between control or treated rats nor was the heart rate response to stimulation altered after timolol treatment. However, in propranolol treated rats the mean rises in heart rate were significantly higher with 3 and 30 Hz stimulation than in control rats.Timolol treatment significantly increased the blood concentration and lowered the heart content of3H‐NA whilst propranolol treatment did not significantly change either blood or heart levels.Log dose‐response curves for mean rises in heart rate after i.v. isoprenaline were not shifted to the right in either propranolol or timolol treated pithed rats. With the lowest doses of isoprenaline (1 and 25 ng), the mean rises in heart rate in timolol treated rats were significantly greater than in the controls.Thus chronic administration of propranolol or timolol decreased the stimulation‐induced increase in plasma3H‐NA but this change in release was not related to reduced rises in blood pressure or heart rate.
PHARMACOLOGICAL CHARACTERIZATION OF NEURONAL DOPAMINE RECEPTORS IN THE RAT HINDQUARTERS, RENAL AND SUPERIOR MESENTERIC VASCULAR BEDS
Authors: DUPONT A. G. , VANDERNIEPEN P. , LEFEBVRE R. A. , BOGAERT M. G. 
Published: September 2010

The present study was designed to characterize the neuronal dopamine receptors involved in the inhibitory effect of apomorphine on neurogenic vasoconstriction in the isolated autoperfused hindquarters, renal and superior mesenteric vascular beds of the rat.
In the three vascular beds, the inhibitory effect of apomorphine on neurogenic vasoconstriction was antagonized by the selective DA2‐receptor antagonist domperidone, but not by the selective DA1‐receptor antagonist SCH 23390. Local administration of these antagonists had no effect on the perfusion pressure per se or on the pressure response to electrical stimulation of the sympathetic innervation.
These results show that the neuronal dopamine receptors present in the rat hindquarters, renal and superior mesenteric vascular beds can be classified as DA2‐receptors.
REDUCED α1‐ADRENORECEPTOR MEDIATED RESPONSIVENESS IN VAS DEFERENS FROM SPONTANEOUSLY HYPERTENSIVE RATS
Authors: DOCHERTY J. R. , WARNOCK PAULA 
Published: September 2010

α‐adrenoreceptor‐mediated responses were investigated in isolated vasa deferentia from spontaneously hypertensive rats (SHR), Wistar Kyoto rats (WKY) and normotensive rats (NWR).
There was no significant difference between NWR, WKY and SHR in the inhibition of the isometric contraction to single pulse field stimulation by the α2‐selective agonist xylazine in prostatic portions, nor by xylazine and the α1‐selective agonist amidephrine in epididymal portions in the presence of nifedipine to prevent postjunctional actions of α1‐selective agonists.
There was no significant difference between NWR, WKY and SHR in the potency of amidephrine in causing a postjunctionally mediated potentiation of the isometric contraction to single pulse field stimulation in prostatic portions but the maximum potentiation was significantly reduced in SHR. However contraction by the calcium entry facilitator, Bay K 8644, was not significantly different between NWR, WKY and SHR. The maximum direct contraction to amidephrine, but not to Bay K 8644, was also significantly reduced in SHR.
It is concluded that the altered α1‐adrenoreceptor‐mediated responsiveness in SHR is due not to genetic strain, but is presumably linked to development of hypertension.