bluuebunny/crossref_metadata_2025_split huggingface dataset:
Event-specific ground motion anomalies highlight the preparatory phase of earthquakes during the 2016–2017 Italian seismicity
Authors: Picozzi Matteo , Spallarossa Daniele , Iaccarino Antonio Giovanni , Bindi Dino 
Published: May 2024

AbstractAlthough physical models are improving our understanding of the crustal processes that lead to large earthquakes, observing their preparatory phases is still challenging. We show that the spatio-temporal evolution of the ground motion of small magnitude earthquakes can shed light on the preparatory phase of three main earthquakes that occurred in central Italy between 2016 and 2017. We analyze systematic deviations of peak ground accelerations generated by each earthquake from the values predicted by a reference ground motion model calibrated for background seismicity and refer to such deviations as event-specific ground motion anomalies (eGMAs). The eGMA temporal behavior indicates that during the activation phase of the main earthquakes, the ground shaking level deviates, positively or negatively, from the values expected for the background seismicity. eGMA can be exploited as beacons of stress change and help to monitor the mechanical state of the crust and the nucleation of large earthquakes.
Recent northward shift of tropical cyclone economic risk in China
Authors: Qin Lianjie , Zhu Laiyin , Liao Xinli , Meng Chenna , Han Qinmei , Li Zixuan , Shen Shifei , Xu Wei , Chen Jianguo 
Published: May 2024

AbstractThe impact of tropical cyclones (TCs) has intensified with continued global warming and socio-economic development. Quantifying the TC economic exposure is a core element of economic risk assessment for TCs. The centroid of annual economic exposure to TCs in China shifted northward at a rate of 19.71 km per year from 2006 to 2020, where changes in the TC tracks contributed a northward shift of 11.22 km per year and changes in GDP distribution contributed a northward shift of 7.75 km per year. The northward shift of TC economic exposure centroid is more than twice as sensitive to the shift of GDP distribution as to that of TC tracks. The phenomenon of the northward shift in TC economic exposure is particularly evident in the subtropical zone in China. Further northward shift of TC exposure could potentially cause higher socio-economic losses in places underprepared for TC hazards. Our result provides references for TC disaster mitigation and preparedness in China.
New insights into red blood cells in tumor precision diagnosis and treatment
Authors: Jia Gaihua , Wang Jun , Wang Hu , Hu Xin , Long Fei , Yuan Chunhui , Liang Chen , Wang Fubing 
Published: May 2024

Red blood cells (RBCs), provide a new research perspective for the development of tumor liquid biopsies, molecular imaging, drug delivery, and other tumor precision diagnosis and treatment technologies.
Malate dehydrogenase as a multi-purpose target for drug discovery
Authors: Fermaintt Charles S. , Wacker Sarah A. 
Published: May 2024

Abstract
Malate dehydrogenase (MDH) enzymes play critical roles in cellular metabolism, facilitating the reversible conversion of malate to oxaloacetate using NAD+/NADH as a cofactor. The two human isoforms of MDH have roles in the citric acid cycle and the malate-aspartate shuttle, and thus both are key enzymes in aerobic respiration as well as regenerating the pool of NAD+ used in glycolysis. This review highlights the potential of MDH as a therapeutic drug target in various diseases, including metabolic and neurological disorders, cancer, and infectious diseases. The most promising molecules for targeting MDH have been examined in the context of human malignancies, where MDH is frequently overexpressed. Recent studies have led to the identification of several antagonists, some of which are broad MDH inhibitors while others have selectivity for either of the two human MDH isoforms. Other promising compounds have been studied in the context of parasitic MDH, as inhibiting the function of the enzyme could selectively kill the parasite. Research is ongoing with these chemical scaffolds to develop more effective small-molecule drug leads that would have great potential for clinical applications.
Self-Perceived Communication Competence of Adults Who Stutter Following Communication-Centered Treatment
Authors: Coalson Geoffrey A. , Byrd Courtney T. , Werle Danielle , Croft Robyn , Mahometa Michael 
Published: May 2024

Purpose:
The purpose of this study was to assess self-perceived communication competence of adults who stutter following participation in a non-ableist treatment for which one of the core components focuses on communication — with no direct or indirect goals designed to reduce or modify stuttered speech.

Method:
Thirty-three adults who stutter completed the Self-Perceived Communication Competence scale (McCroskey & McCroskey, 1988) pre- and posttreatment.

Results:
Findings indicate significant gains in self-perceived communication competence posttreatment. Pre- to posttreatment changes in stuttering did not predict posttreatment gains in self-perceived communication competence.

Conclusion:
The present study demonstrates that improvement in communication can be achieved independent of improvement in fluency, lending further support to the notion that stuttering and communication competence are distinct constructs.
Caregiver Self-Efficacy in Relation to Caregivers' History of Language and Reading Difficulties and Children's Shared Reading Experiences
Authors: Davison Kelsey E. , Ronderos Juliana , Gomez Sophia , Boucher Alyssa R. , Zuk Jennifer 
Published: May 2024

Purpose:
Emerging literature suggests caregiver self-efficacy is an important factor related to caregivers' shared reading practices with their children. Reduced shared reading has been documented among families of caregiver(s) with language-based learning disabilities (LBLD). Yet, it remains unclear whether caregivers' history of language and reading difficulties is associated with caregiver self-efficacy. The purpose of this study was to examine whether self-efficacy in language- and reading-related caregiver activities related to caregiver history of language and reading difficulties and shared reading practices.

Method:
One hundred seventy-six caregivers of children aged 18–60 months completed a custom self-efficacy in language- and reading-related caregiver activities questionnaire, as well as demographic, history of language and reading difficulties (used both as a continuous measure and to dichotomize caregivers with and without LBLD history), and shared reading measures in a one-time survey.

Results:
Caregivers with a history of LBLD reported an overall lower self-efficacy and a reduced amount of time reading with their children per week than caregivers without LBLD history. Examining caregiver history of language and reading difficulties continuously across the whole group, self-efficacy mediated the relationship between caregiver difficulties and shared reading practices, even when caregiver education was incorporated as an additional mediator in models.

Conclusions:
Findings indicate that self-efficacy and caregiver education mediate the relationship between caregiver history of language and reading difficulties and shared reading practices. Consideration of self-efficacy by clinicians and educators is warranted when promoting shared reading practices to caregivers of young children. There is a need for future research to examine relationships between self-efficacy and shared reading among caregivers with LBLD of culturally and linguistically diverse backgrounds.

Supplemental Material:

https://doi.org/10.23641/asha.25901590
Student Clinical Accommodations in Speech-Language Pathology and Audiology Externships: A Survey Study
Authors: Sizemore Erin Redle , Subramanian Anu , Hatfield Stacie M. 
Published: May 2024

Purpose:
The number of individuals with disabilities enrolling in speech-language pathology and audiology graduate programs is increasing. While academic accommodations for classroom learning are well accepted, there is very little information regarding the feasibility of accommodations in external clinical placements. The goal of this article was to describe the current processes and the future feasibility of such accommodations.

Method:
External clinical supervisors completed a Likert-type survey regarding past experiences supervising students with disabilities, the types of requested accommodations, and the feasibility of the various types of accommodations in their setting.

Results:

Of the respondents (
N
= 49), only nine individuals reported supervising at least one student with a disability. Most frequently, external clinical educators generally did not learn about the disability or need for accommodations until the student was already in the placement. Attendance modifications were the most frequently requested accommodation (
n
= 6), followed by timing modifications (
n
= 5) and load adjustments (
n
= 4). External clinical educators reported coaching and support (
n
= 33), the use of assistive technology (
n
= 32), and timing accommodations (
n
= 30) were the most feasible accommodations. Most respondents were
definitely
(
n
= 23) or
probably
(
n
= 21) willing to supervise a student with a disability.

Conclusions:
The study's findings show that students are not disclosing the need for accommodations until after the placement begins. External clinical educators are willing to support students with disabilities and describe a variety of accommodations that could potentially be implemented into external clinical placements.
A novel motion compensation algorithm for spaceborne inverse synthetic aperture radar imaging of air target under low signal‐to‐noise ratio condition
Authors: Zhou Yichen , Wang Yong 
Published: May 2024

AbstractThe spaceborne Inverse Synthetic Aperture Radar (ISAR) has garnered significant attention due to its extensive observation range and robust anti‐attack capabilities. Consequently, the ISAR imaging research of air targets based on a spaceborne platform has crucial application value. However, unlike the traditional ground‐based radar system, the spaceborne platform moves along its own orbit while observing the air target, and the received signal energy is weakened due to the extended observation distance. Therefore, it is important to optimise the existing ISAR imaging geometry models and motion compensation algorithms. The authors first construct a geometric model of spaceborne ISAR imaging for air targets. Aiming at the problem of low signal‐to‐noise ratio (SNR), a novel translational motion compensation algorithm based on motion parameter estimation is proposed. The algorithm compensates for both distance migration and Doppler migration caused by the first‐order and second‐order motion components of relative motion, respectively. Finally, simulation and semi‐physical simulation results validate the effectiveness and superiority of the proposed algorithm under different SNR and motion conditions.
Effets de la 2′-O-méthylation de l’ARN génomique du VIH-1 sur la réplication virale
Authors: Decombe Alice , El-Kazzi Priscila , Nisole Sébastien , Decroly Étienne 
Published: May 2024

Les ARN du virus de l’immunodéficience humaine sont décorés par des marques épitranscriptomiques, dont des 2′-O-méthylations internes. Ces marques ajoutées par une enzyme cellulaire, FTSJ3, sont des marqueurs du « soi ». Elles ont des effets proviraux en protégeant l’ARN viral de la détection par le senseur de l’immunité innée MDA5, et en limitant sa dégradation par l’exonucléase cellulaire ISG20, induite par l’interféron. Ces méthylations ont également un effet antiviral, dans la mesure où elles perturbent la rétrotranscription du génome ARN du virus, in vitro et dans des cellules quiescentes. Un équilibre subtil existe donc entre les effets proviraux et antiviraux des 2′-O-méthylations, assurant ainsi une réplication optimale du virus. Ces découvertes ouvrent des perspectives d’optimisation des ARN thérapeutiques à effet antiviral, par la méthylation sélective de certains nucléotides.
L’émergence d’un « savoir-être » personnel et professionnel chez des médecins à la suite d’une formation « corps-esprit »
Authors: Lachance Josée , Desbiens Jean-François , Vinit Florence 
Published: May 2024

Contexte et problématique : La pédagogie médicale vise à construire et à améliorer les compétences des professionnels de santé. Récemment, le thème de la corporéité émerge comme un enjeu de soutien à l’apprentissage, de relation aux patients et de prévention du burnout. La pratique du Sensible (PS), développé par Danis Bois, est une intervention corps et esprit (Mind-Body Medicine) favorisant la relation à son propre corps et à son mouvement, au service d’une meilleure conscience de soi et des autres. Aucune étude n’a été réalisée afin d’examiner les effets des PS chez des professionnels de la santé où l’interaction autour du corps occupe une place centrale. Objectif : Explorer l’influence de la formation aux PS chez des médecins. Leur conscience d’eux-mêmes, la qualité de leur présence aux autres, ainsi que l’interaction entre leur conception de la santé et leur pratique, ont été examinées. Méthodes : Une recherche qualitative utilisant la théorie ancrée a permis d’effectuer deux types d’entrevues semi-structurées (compréhensive et d’explicitation) auprès de six médecins ayant terminé leur formation en PS en France. Résultats : L’article présente spécifiquement les résultats liés à la sphère professionnelle des participants. L’analyse par catégorie conceptualisante souligne qu’au-delà d’une gestion du stress plus efficace, ces pratiques semblent avoir développé une meilleure qualité de « savoir-être », aidant les participants à améliorer leur compétence relationnelle intra et inter personnelle dans leur vie professionnelle. Les PS ouvrent ainsi un champ prometteur en pédagogie médicale, par l’intégration d’une formation passant par la corporéité.
The linked nail/plate construct for the management of distal femur fractures in the elderly
Authors: Saraglis Georgios , Khan Anwar , Sharma Amit , Pyakurel Sagar , Rabbani Sayed Fazal Elahi , Arafa Mohamed Shawky Abdelhamid 
Published: May 2024

Background: Distal femoral fractures represent a challenging injury, with many different factors such as the method of fixation, complexity of fracture pattern, and patient co-morbidities affecting the outcome. Lots of surgical treatment options have been described, but recently double construct fixation, using a nail/plate combination, has received lots of attention, a technique that leads to faster weight-bearing, low risk of metalwork failure, and non-union. The purpose of this study was to investigate the effectiveness of the linked nail/plate construct in the management of complex distal femur fractures and to investigate if the above technique leads to faster recovery and earlier radiographic union. Materials and methods: In total 15 cases were included in the study, that underwent a combined nail/plate construct for a distal femur fracture between January 2021 and December 2022. Only cases with a linked nail/plate construct were included, with a minimum follow-up of 1 year. Open femur fractures, single implant fixation cases, and revision procedures were excluded. Results: In this cohort study, 11 cases were periprosthetic distal femur features, and 4 cases were distal femur fractures around a native knee joint. The mean age group was 74 years, 86.6% of the patients had a BMI > 25 and the mean time to fracture union was 24 weeks (range from 20 to 26 weeks). All cases healed uneventfully and the complication rate was 6.6%, including 1 case of superficial infection which resolved completely with oral antibiotics. Conclusion: The increasing age population, the complexity of distal femoral fractures along with the increasing physiological demands of the elderly population, drive the need for double fixation constructs that allow early mobilization and enhance fracture stability. In our study, the linked nail/plate construct seems to provide adequate stability and excellent union rates (100%) with no associated increased risk of complications.
COVID-19 vaccination among adolescents and young adults with chronic
kidney conditions: a single-center experience
Authors: Baltu Demet , Kurt-Sukur Eda Didem , Tastemel Ozturk Tugba , Gulhan Bora , Ozaltin Fatih , Duzova Ali , Topaloglu Rezan 
Published: May 2024

Abstract
Background Following the pandemic of COVID-19, the main focus has been on
COVID-19 vaccines and herd immunity. Although the safety of the COVID-19
vaccines has been shown in clinical trials, children with chronic diseases were
not included. We investigated the side effect profile and safety of the COVID-19
vaccines in adolescents with kidney disease.
Methods A questionnaire including demographic information, history of
COVID-19, vaccination status, and vaccine-related side effects was administered
to the patients with chronic kidney disease (CKD) stage 2–5, glomerular disease
treated with immunosuppression, and kidney transplant recipients.
Results Ninety-eight patients were vaccinated with CoronaVac-inactivated
SARS-CoV-2 (n=16) or BNT162b2 messenger RNA (mRNA) COVİD-19 (n=82) vaccine. The
mean age was 16.90±2.36 years. The most common side effects were local pain,
fatigue, and fever. No serious side effects or renal disease flare were
observed. There was no significant difference in the side effects reported after
the BNT162b2 mRNA-RNA as compared to the Corona Vac-inactivated SARS-CoV-2
vaccine. No significant relationship was found between the frequency of side
effects according to age, glomerular filtration rate, immunosuppressive
treatments, CKD stage, and the underlying disease.
Conclusion Although the reported data are subjective because they were
obtained through a questionnaire and studies with long-term follow-up are
needed, our early experience suggests that the vaccine is safe and adolescents
and young adults should be encouraged to be vaccinated.
Cancer and Spirituality—Underutilized Resource for Cancer Care in India
Authors: Murthy Srinivasa R. 
Published: May 2024

AbstractLiving with cancer is a challenge to the individuals and their families. This is a personal perspective of a person living with a diagnosis of cancer for over a decade and as psychiatrist supporting others in a similar situation and their caregivers. The challenges are medical, psychological, social, and spiritual. In the care of persons living with a diagnosis of cancer, there is a need to mobilize all of the resources toward relief and recovery. In the Indian context, to make sense of the uncertainties, spirituality in various forms is harnessed by the patients and their families. Epics and religious stories are routinely used to make sense of the pain, distress, and uncertainties of living with cancer. It is for the caregiving professionals to understand this rich resource in India, and develop ways of maximizing the value of spirituality in the care programs. Systematic study, documentation, and adaptation of the spiritual resources of different religions and communities in the cancer care could be an important Indian contribution to cancer care in the world. Such a development could be similar to the universal acceptance of the value of yoga in the recent years.
Does Side Matter? The Impact of Free Flap Harvest Laterality on Ambulatory Function in Lower Extremity Traumatic Reconstruction
Authors: Moshal Tayla , Roohani Idean , Stanton Eloise W. , Zachary Paige K. , Boudiab Elizabeth , Lo Jessica , Markarian Emily , Carey Joseph N. , Daar David A. 
Published: May 2024

Abstract
Background Free flaps are essential for limb salvage in patients with lower extremity (LE) trauma; however, significant donor-site morbidity could impact functional outcomes. This study compares postoperative ambulatory function between contralateral and ipsilateral free flap harvest in LE traumatic reconstruction.
Methods A retrospective review was performed on patients who underwent LE reconstruction at a level 1 trauma center from 2009 to 2022. Flap characteristics, injury history, and ambulatory function were collected. Flap harvest laterality was determined in relation to the injured leg. The flaps were categorized as either fasciocutaneous or those that included a muscle component (muscle/myocutaneous). Chi-squared and Mann–Whitney tests were used for statistical analysis.
Results Upon review, 173 LE free flaps were performed, of which 70 (65.4%) were harvested from the ipsilateral leg and 37 (34.6%) were from the contralateral leg. Among all LE free flaps, the limb salvage rate was 97.2%, and the flap survival rate was 94.4%. Full ambulation was achieved in 37 (52.9%) patients in the ipsilateral cohort and 18 (48.6%) in the contralateral cohort (p = 0.679). The average time to full ambulation did not vary between these cohorts (p = 0.071). However, upon subanalysis of the 61 muscle/myocutaneous flaps, the ipsilateral cohort had prolonged time to full ambulation (6.4 months, interquartile range [IQR]: 4.8–13.5) compared with the contralateral one (2.3 months, IQR: 2.3 [1.0–3.9]) p = 0.007. There was no significant difference in time to full ambulation between flap harvest laterality cohorts among the fasciocutaneous flaps (p = 0.733).
Conclusion Among free flaps harvested from the ipsilateral leg, fasciocutaneous flaps were associated with faster recovery to full ambulation relative to muscle/myocutaneous flaps. Since harvesting muscle or myocutaneous flaps from the ipsilateral leg may be associated with a slower recovery of ambulation, surgeons may consider harvesting from a donor site on the contralateral leg if reconstruction requires a muscle component.
Reducing asymmetric cost behaviors: Evidence from digital innovation
Authors: Du Xinyi , Jiang Kangqi , Zheng Xian 
Published: May 2024

AbstractThis study quantifies the impact of digital innovation on corporate performance, offering insights into the sustainability of digital innovation’s impact and providing guidance for firms embarking on their digital innovation journey. We examine the effect of digital innovation on cost stickiness using patent reports spanning from 2007 to 2022. The baseline analysis results reveal that digital innovation significantly mitigates cost stickiness in companies. This finding remains robust after addressing endogeneity concerns and conducting various robustness tests. We probe potential mechanisms and discover that digital innovation reduces cost stickiness by enhancing the quality of internal controls, improving resource-adjustment efficiency, and addressing managerial over-optimism. Heterogeneity analysis indicates a more pronounced impact of digital innovation on reducing asymmetric cost behaviors in larger firms, those beyond the growth stage, and in regions with active digital procurement, well-developed digital taxation governance, and sound judiciary infrastructures. Additionally, our expanded analysis confirms the financial benefits of digital innovation in reducing cost stickiness. A notable discovery is the negative correlation between digital transformation and cost stickiness within digitally innovative firms, underscoring the greater significance of digital innovation over mere digitization. Overall, this study significantly advances our understanding of how digital innovation influences cost management strategies.