bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pirfenidone's Potential for Motor Recovery following Spinal Cord Compression Injury
Authors: Wazir Noman Ullah , Ara Nighat , Khattak Saima Mumtaz , Waheed Nazish , Ghani Usman , Khattak Maria Azam 
Published: May 2024

Objective: The aim of this research was to access the ability of pirfenidone in improving motor activity of hindlimbs in rats following compression injury to spinal cord. Study Design: Experimental lab-based study. Settings: Institute of Basic Medical Sciences, Khyber Medical University Peshawar, Pakistan. Duration: From March 2020 to April 2023. Methods: Injury induction at the T7 spinal cord level was carried out using a 70gm force aneurysm clip in rats. The rats were divided into three groups: Group A received a daily placebo, Group B received a daily dose of pirfenidone at 200 mg/kg/day, and Group C received a daily dose of pirfenidone at 500 mg/kg/day. Each group was further subdivided into two sub-groups, labeled as Groups 1 and 2, each consisting of 5 rats. The experiment lasted for 14 and 28 days. On the final day, all rats underwent BBB scoring to evaluate the motor activity in their hind limbs. Results: BBB scores showed statistically significant differences both between and within groups. Among the SCI groups, those treated with pirfenidone displayed higher BBB scores compared to those without pirfenidone treatment. Conclusion: Pirfenidone may improve motor function post-spinal cord injury by reducing fibrosis, preventing collagen buildup in the core of glial scars, and reducing reactive astrocytosis in the scar's outer region. This dual action could promote axonal regeneration and enhance synaptic connections, aiding in neurological recovery.
Kuat Lentur Beton Menggunakan Agregat Batu Petangis dan Pasir Semboja dengan Penambahan Botol Plastik
Authors: Widianto Topik Wahyu , Indriani Andi Marini , Utomo Gunaedy 
Published: May 2024

Utilizing local materials is a strategic step in optimizing concrete production in East Kalimantan. There's an example supply of petangis stone and semboja sand aggregates. Apart from that, using various wastes, including plastic waste, in concrete production is also a current issue. This study aims to investigate the potential substitution of fine aggregates with PET and combine them with local materials, to understand their impact on the bending strength of concrete. The study tested concrete bending strength using 15x15x60 cm blocks with PET plastic substitutions at 0.30%, 0.45%, and 0.60% of sand weight, comparing them with PET-free concrete. The research results show that adding 0.30 and 0.45% PET plastic bottles causes a decrease in the flexural strength of concrete. This is related to the influence of changes in the composition of the concrete mix, including factors such as uneven aggregate distribution and less-than-optimal material binding. Flexural strength increases at a percentage of 0.60% by 3.7% or 3.3 MPa and shows better results than normal concrete. So the PET percentage can be used as a recommendation in making concrete using local materials such as petangis stone aggregate and semboja sand.
Analisis Faktor-Faktor Yang Berpengaruh Terhadap Pencemaran Air Sungai Mahakam Menggunakan Pemodelan Geographically Weighted Logistic Regression Pada Data Dissolved Oxygen
Authors: Lestari Vivi Dwi , Suyitno Suyitno , Siringoringo Meiliyani 
Published: May 2024

Geographically Weighted Logistic Regression (GWLR) model is a local model of the logistic regression model applied to spatial data. Parameter estimation is performed at each observation location using spatial weighting. The spatial weighting is calculated by using an adaptive tricube function and bandwidth optimum was obtained based on Generalized Cross Validation (GCV) criteria. The purpose of this study was to obtain a GWLR model on the water pollution indicator Dissolve Oxygen (DO) in Mahakam River in East Kalimantan Province and to find factors affecting the probability of the Mahakam River water was not polluted based on DO indicator. The research data is secondary obtained from Environmental Department of East Kalimantan. The parameter estimation method was Maximum Likelihood Estimation (MLE). The research result showed that the closed form of ML estimator could not be found analytically and it can be approximed by using Newton-Raphson iterative methods. Based on the result of partial hypothesis test, the factors influencing the probability of the Mahakam River water was not polluted is different for every observation location. They were phosphate consentration, total dissolved solid and nitrite consentration. The factor influencing globally was total dissolved solid.
Model Regresi Hazard Rate Weibull Kesembuhan Pasien Rawat Inap Demam Berdarah Dengue (DBD) Di RSUD Panglima Sebaya Tanah Grogot
Authors: Fajriati Nur Ainun , Suyitno Suyitno , Wasono Wasono 
Published: May 2024

Univariate Weibull Regression (RWU) is a regression model development of the Univariate Weibull distribution, where the scale parameters is expressed in terms of the regression parameters. Univariate Weibull Regression Models discussed in this study are Weibull survival regression and the Weibull hazard regression model. Weibull regression models in this study was applied to lifetime data containing the right censored data for Dengue Hemorrhagic Fever (DHF) inpatients at the Regional General Hospital (RSUD) Panglima Sebaya Tanah Grogot, Paser Regency, Kalimatan Tinur. The purpose of this study was to obtain a Weibull regression model and to determine the factors that affect the patients is survive (have not recovery) and the recovery rate of DHF patients. The parameter estimation is the Maximum Likelihood Estimation (MLE) which is solved by using the Newton-Raphson iterative method. The study conclude that the factors influencing the patients is survive (have not recovery) and the recovery rate of DHF patients at RSUD Panglima Sebaya Tanah Grogot were platelets and leucocytes.
A comparison of endoscopic endonasal versus open approaches for skull base chordoma: a comprehensive National Cancer Database analysis
Authors: Soffer Justin M. , Ulloa Ruben , Chen Sonja , Ziltzer Ryan S. , Patel Vijay A. , Polster Sean P. 
Published: May 2024

OBJECTIVE
The authors of this study aimed to investigate independent prognostic factors of survival with a particular focus on comparing the safety and efficacy of endoscopic endonasal versus open approaches in the surgical management of skull base chordoma.

METHODS
A retrospective National Cancer Database review of skull base chordoma patients was performed to capture resection cases from 2010 to 2020, evaluating overall survival (OS), early postoperative mortality, readmission rates, and hospital length of stay (LOS) between surgical approaches and the independent prognostication of death utilizing Cox multivariate regression analysis.

RESULTS
Among the 736 patients included in the cohort, 456 patients (62.0%) and 280 patients (38.0%) underwent endoscopic endonasal and open resection, respectively. These values represent a rate of change over the study period of +4.1 versus –0.14 cases per year, respectively. Gross-total resection was achieved in 32.5% of cases. A positive margin status was found in 51.8% of cases. There was no association between extent of resection and surgical approach (p = 0.257). There was no difference in OS (p = 0.562), 30- and 90-day mortality (p = 0.209 and 0.126, respectively), and 30-day readmission (p = 0.438) between the two surgical groups. The mean LOS was reduced by 2.1 days in the endoscopic cohort (p = 0.013) compared with the open approach cohort. Finally, multivariate analysis revealed a tumor size ≥ 4 cm (HR 4.03, p = 0.005) and public insurance (HR 2.76, p = 0.004) as negative predictors of survival and treatment at an academic center (HR 0.36, p = 0.043) as a positive prognosticator of survival.

CONCLUSIONS
The endoscopic endonasal approach has been increasingly utilized over time and touts noninferiority with respect to safety and efficacy with a marked improvement in LOS, which carries substantial implications for both healthcare costs and enhanced patient recovery. Future prospective studies are necessary to further delineate trends and surgical outcomes for skull base chordoma.
Characterizing the presentation, management, and clinical outcomes of patients with intradural spinal chordomas: a systematic review
Authors: Saint-Germain Max A. , Kramer Patrick , Weber-Levine Carly , Jiang Kelly , Al-Mistarehi Abdel-Hameed , Redmond Kristin J. , Lee Sang H. , Bettegowda Chetan , Theodore Nicholas , Lubelski Daniel 
Published: May 2024

OBJECTIVE
Chordomas are locally aggressive neoplasms of the spine or skull base that arise from embryonic remnants of the notochord. Intradural chordomas represent a rare subset of these neoplasms, and few studies have described intradural chordomas in the spine. This review evaluates the presentation, management, and outcomes of intradural spinal chordomas.

METHODS
A systematic review of PubMed/MEDLINE, EMBASE, Cochrane Library, Scopus, and Web of Science was performed. Studies describing at least 1 case of intradural chordomas anywhere in the spine were included. Extracted details included presenting symptoms, radiological findings, treatment course, follow-up, and disease progression.

RESULTS
Thirty-one studies, with a total of 41 patients, were included in this review. Seventy-six percent (31/41) of patients had primary intradural tumors, whereas 24% (10/41) presented with metastasis. The most common signs and symptoms were pain (n = 27, 66%); motor deficits (n = 20, 49%); sensory deficits (n = 17, 42%); and gait disturbance (n = 10, 24%). The most common treatment for intradural chordoma was resection and postoperative radiotherapy. Sixty-six percent (19/29) of patients reported improvement or complete resolution of symptoms after surgery. The recurrence rate was 37% (10/27), and the complication rate was 25% (6/24). The median progression-free survival was 24 months (range 4–72 months). Four patient deaths were reported. The median follow-up time was 12 months (range 13 days–84 months).

CONCLUSIONS
Treatment of intradural spinal chordomas primarily involves resection and radiotherapy. A significant challenge and complication in management is spinal tumor seeding after resection, with 9 studies proposing seeding as a mechanism of tumor metastasis in 11 cases. Factors such as tumor size, Ki-67 positivity, and distant metastasis may correlate with worse outcomes and demonstrate potential as prognostic indicators for intradural spinal chordomas. Further research is needed to improve understanding of this tumor and develop optimal treatment paradigms for these patients.
EP300 through upregulating the expression of vimentin to promote the progression of chordoma
Authors: Wen Lingzhi , Xie Bin , Li Hui , Huang Jun , Shi Ying , Tao Yongguang , Chen Yuanbing 
Published: May 2024

OBJECTIVE
There is a lack of effective drugs to treat the progression and recurrence of chordoma, which is widely resistant to treatment in chemotherapy. The authors investigated the functional and therapeutic relevance of the E1A-binding protein p300 (EP300) in chordoma.

METHODS
The expression of EP300 and vimentin was examined in specimens from 9 patients with primary and recurrent chordoma with immunohistochemistry. The biological functions of EP300 were evaluated with Cell Counting Kit-8, clonogenic assays, and transwell assays. The effects of EP300 inhibitors (C646 and SGC-CBP30) on chordoma cell motility were assessed with these assays. The effect of the combination of EP300 inhibitors and cisplatin on chordoma cells was evaluated with clonogenic assays. Reverse transcription quantitative polymerase chain reaction and Western blot techniques were used to explore the potential mechanism of EP300 through upregulation of the expression of vimentin to promote the progression of chordoma.

RESULTS
Immunohistochemistry analysis revealed a positive correlation between elevated EP300 expression levels and recurrence. The upregulation of EP300 stimulated the growth of and increased the migratory and invasive capabilities of chordoma cells, along with upregulating vimentin expression and consequently impacting their invasive properties. Conversely, EP300 inhibitors decreased cell proliferation and downregulated vimentin. Furthermore, the combination of EP300 inhibition and cisplatin exhibited an enhanced anticancer effect on chordoma cells, indicating that EP300 may influence chordoma sensitivity to chemotherapy.

CONCLUSIONS
These findings indicate that EP300 functions as an oncogene in chordoma. Targeting EP300 offers a novel approach to the development and clinical treatment of chordoma.
Effects of hours of sleep on ImPACT concussion testing: comparing baseline with postinjury scores
Authors: Hrabarchuk Eugene I. , Kalagara Roshini , Ezzat Bahie , Rentzeperis Frederika , Leska Tomasina M. , Schupper Alexander J. , Rodriguez Benjamin , Ali Muhammad , Quinones Addison , McCarthy Lily , Carr Mathew T. , Lehman Arielle B. , Gometz Alex , Lovell Mark , Choudhri Tanvir F. 
Published: May 2024

OBJECTIVE
The influence of sleep on baseline and postconcussion neurocognitive performance prior to Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) is poorly understood. Since ImPACT is widely used in youth sport to assess neurocognitive performance before and after head injury, it is important to delineate factors that affect testing performance. While some have reported correlations between fewer hours of sleep and lower scores on baseline tests, others have not observed any such associations. Therefore, the authors sought to compare the relationship between sleep and neurocognitive performance on ImPACT at both baseline and postinjury.

METHODS
The authors queried a database of 25,815 ImPACT tests taken from 2009 to 2019 by athletes aged 12–22 years. There were 11,564 baseline concussion tests and 7446 postinjury concussion ImPACT tests used in the analysis. Linear regression was used to model the effect of sleep on baseline and postconcussion ImPACT scores adjusting for sex, age, learning disability, attention-deficit/hyperactivity disorder, number of prior concussions, number of games missed, and strenuous exercise before testing.

RESULTS
Mean composite scores expectedly were all significantly lower in the post–head injury group compared with the baseline group. In the multivariable analysis, at baseline, hours of sleep significantly affected symptom scores (β = −1.050, 95% CI −1.187 to −0.9138; p < 0.0001). In the postinjury multivariable analysis, verbal memory (β = 0.4595, 95% CI 0.2080–0.7110; p = 0.0003), visual memory (β = 0.3111, 95% CI 0.04463–0.5777; p = 0.0221), impulse control (β = −0.2321, 95% CI −0.3581 to −0.1062; p = 0.0003), and symptom scores (β = −0.9168, 95% CI −1.259 to −0.5750; p < 0.0001) were all affected by hours of sleep.

CONCLUSIONS
Hours of sleep did not alter neurocognitive metrics at baseline but did have an impact on post–head injury metrics. These findings suggest that individuals may be able to compensate for lack of sleep at baseline but not immediately after concussion. Concussions may reduce cognitive reserve or detract from the brain’s resources, making sleep even more important for proper neurocognitive functioning postconcussion. Future work will analyze the effects of sleep on postconcussion test performance.
Development of moyamoya arteriopathy following treatment of intracranial tumors: clinical and radiographic characterization
Authors: Lee Jong Seok , Storey Armide , Lanpher Arianna , Smith Edward R. 
Published: May 2024

OBJECTIVE
Moyamoya arteriopathy can develop in patients with brain tumors, particularly when associated with neurofibromatosis type 1 (NF1) or cranial irradiation. The present study aimed to analyze the clinical outcomes of moyamoya after brain tumor treatment and elucidate the effect of revascularization on brain tumors.

METHODS
The authors retrospectively reviewed clinical and radiographic findings in 27 patients with brain tumors who developed moyamoya requiring revascularization surgery between January 1985 and June 2017 at a single institution. The long-term clinical and neuroimaging-based outcomes were analyzed.

RESULTS
Among 27 patients, 22 patients underwent radiotherapy, and 12 patients had NF1. The mean ages at diagnosis of brain tumors and moyamoya were 4.4 years and 10.3 years, respectively. The mean interval between radiotherapy and moyamoya diagnosis was 4.0 years. The mean follow-up period after revascularization surgery was 8.5 years. Among 46 affected hemispheres in 27 patients, the patients who underwent radiotherapy (30 hemispheres in 22 patients) had a higher incidence of Suzuki stage 5 or 6 (20% [6/30] vs 0% [0/8]) and infarction (63.6% [14/22] vs 0% [0/5]) compared with patients without radiotherapy (8 hemispheres in 5 patients). After revascularization, stroke occurred in 4 patients, and 6 hemispheres showed Matsushima grade C, all of which occurred in patients with a history of radiotherapy. The residual brain tumors progressed in 4 of 21 patients (19%) after revascularization, comparable to the progression rates of brain tumors without revascularization in previous literature.

CONCLUSIONS
Patients with brain tumors can develop moyamoya that exhibits characteristic clinical and radiographic features of idiopathic MMD. Moyamoya associated with cranial irradiation has a higher incidence of stroke with less capacity for revascularization, requiring thorough evaluations and timely treatment. Revascularization does not appear to have any effect on the progression of existing brain tumors.
Enhancing transparency and accountability in public administration through information technology utilization
Authors: Sarifudin Risman , Damanik Fritz Hotman Syahmahita 
Published: May 2024

Many problems regarding the use of information technology to provide and increase transparency and accountability in public administration must be studied more deeply. Based on these problems, this study aims to explore and examine the use of information technology in increasing transparency and accountability in terms of public administration. The method used in this study is the qualitative research method. Data Collection Techniques in this study go through three stages: observation, interviews, and search for supporting written data. After the data is obtained, data analysis is carried out. Data analysis is carried out using qualitative analysis methods. The findings underscore that IT implementation significantly improves accessibility to public information, fosters a culture of efficiency through streamlined administrative practices, and strengthens oversight mechanisms. Moreover, the study identifies challenges related to data security, disparities in IT access, and resistance to technological change within administrative structures. Recognizing the necessity for comprehensive policies, the research emphasizes the need for governance frameworks that embrace technological advancements and address associated challenges. The study advocates for a holistic approach to maximize the positive impact of IT on transparency and accountability in public administration. This research contributes to the discourse on the intersection of technology and governance, providing insights that can inform policymakers, administrators, and researchers in advancing effective strategies for utilizing IT to foster transparency and accountability in public administration.
Applying coffee processing waste as an organic material against growth and yield of caisim plant (Brassica chinensis var. parachinensis)
Authors: Pramesti Fadli Setio , Firnia Dewi , Putri Widia Eka , Sodiq Abdul Hasyim 
Published: May 2024

The research aimed to examine the quality of coffee waste in solid and liquid material in promoting the growth and yield of caisim plants (Brassica chinensis var. parachinensis). This research was conducted from November until December 2023 in Sukabumi Roadway, RT. 002 RW. 001 Ciwedus Village, Cilegon District, Cilegon city, Banten. The experimental design used in this study was a Randomized Block Design (RBD) consisting of one factor, which is with eight treatment levels: without fertilizer application (control) (P0), 10 g of solid coffee processing waste compost (P1), 20 g of solid coffee processing waste compost (P2), 30 g of solid coffee processing waste compost (P3), 100 ml liquid coffee processing waste compost (P4), 150 ml liquid coffee processing waste compost (P5), 200 ml liquid coffee processing waste compost (P6), and 250 ml liquid coffee processing waste compost (P7). The results showed that treatment P5, gave the best results in terms of growth in plant height (26.30 cm), number of leaves (9.00 leaves), plant fresh weight (43.23 g), root wet weight (4.03 g), and root length (17.80 cm). For solid coffee ground treatment, the P3 treatment has a significant effect on plant height (25.30 cm), number of leaves (7.00 leaves), plant wet weight (22.60 g), and root length (17.03 cm). The findings of this research theoretically support the theory proposed by Putri et al. in 2017, indicating that the application of 30g/150 ml had the most favorable impact on the growth of lettuce plants (Lactuca sativa L.).
IMPLEMENTASI BIODIESEL HVO DI INDONESIA : METODE ECONOMIC BENEFIT COST ANALYSIS
Authors: Imaniar Rizani 
Published: May 2024

Dalam forum United Nation Framework Convention on Climate Change (UNFCCC) – Conference of Parties (COP) ke-21 pada Desember 2015, Presiden Republik Indonesia menyampaikan komitmen nasional terkait penurunan emisi gas rumah kaca (GRK) salah satunya melalui pengembangan energi terbarukan. Komitmen nasional ini ditindaklanjuti dengan pengembangan roadmap energi nasional yang dikenal dengan Grand Strategi Energi Nasional (GSEN) oleh Dewan Energi Nasional (DEN) dimana Indonesia memiliki target Nationally Determined Contributions (NDC) sebesar 314 juta ton CO2e per tahun penurunan emisi karbon dari sektor energi yang harus dicapai pada tahun 2030 (hingga 2020 telah tercapai 64,4 juta ton CO2e per tahun).
Salah satu upaya yang dilakukan terkait pengembangan energy terbarukan adalah dengan implementasi biodiesel yang sejak tahun 2019 telah mulai diimplementasikan dengan pencampuran bahan bakar diesel dengan Fatty Acid Methyl Ester (FAME) yang saat ini dikenal dengan B30 (blending 30% bahan bakar nabati dengan 70% bahan bakar diesel). Namun Secara teknis B30 dengan blending FAME tidak bisa melebihi 30% karena keterbatasan teknis (water content, monoglyceride, dll). Sedangkan Presiden Republik Indonesia memiliki target yang cukup ambisius yaitu tingkat blending yang lebih tinggi yaitu B40 bahkan hingga B50. Untuk itu, Hydrotreated Vegetable Oil (HVO) muncul sebagai solusi yang dapat memenuhi dari sisi kriteria teknis. Namun terdapat beberapa pertimbangan dari sisi keekonomian nya.
Setelah penelitian ini mengukur kelayakan dari sisi finansial proyek, serta mempertimbangkan pula beberapa aspek benefit lain yang muncul antara lain seperti kontribusi terhadap target pencapaian NDC sebesar 521,000 ton reduksi CO2e per tahun, penghematan current account deficit dan lain sebagainya maka proyek ini layak dari sisi Economic Benefit Cost Analysis.