bluuebunny/crossref_metadata_2025_split huggingface dataset:
Creativity in Ergonomic Design: A Supplemental Value-Adding Source for Product and Service Development
Authors: Zeng Liang , Proctor Robert W. , Salvendy Gavriel 
Published: September 2010

Objective: This article investigates the role of creativity in ergonomic design and the generic process of developing creative products and services. Background: Creativity is gaining increased emphasis in both academia and industry. More than 50 years of research in creativity indicates that creativity is key to product and service innovation. Nevertheless, there is scarcely any comprehensive review dedicated to appraising the complex construct of creativity, the underlying cognitive process, and the role of creativity in product and service development. Method: We review relevant literature regarding creativity, creative cognition, and the engineering design process to appraise the role of creativity in ergonomic design and to construct a conceptual model of creative product and service development. Results: A framework of ergodesign creativity is advanced that highlights the central role of creativity in synergistically addressing the four dimensions of ergonomic design: functionality, safety, usability, and affectivity. A conceptual model of creative design process is then constructed that is goal oriented and is initiated by active problem finding and problem formulating. This process is carried out in a recursive and dynamic way, facilitated by creative thinking strategies. Conclusion: It is proposed that ergodesign creativity can add supplemental value to products and services, which subsequently affects consumer behavior and helps organizations gain competitive advantage. Application: The proposed conceptual framework of ergodesign creativity and creative design process can serve as the ground for future theory development. Propositions advanced in this study should facilitate designers generating products and services that are creative and commercially competitive.
Bimodal Stimulus Presentation and Expanded Auditory Bandwidth Improve Older Adults’ Speech Perception
Authors: Brault Lynn M. , Gilbert Jaimie L. , Lansing Charissa R. , McCarley Jason S. , Kramer Arthur F. 
Published: September 2010

Objective: A pair of experiments investigated the hypothesis that bimodal (auditory-visual) speech presentation and expanded auditory bandwidth would improve speech intelligibility and increase working memory performance for older adults by reducing the cognitive effort needed for speech perception. Background: Although telephone communication is important for helping older adults maintain social engagement, age-related sensory and working memory limits may make telephone conversations difficult. Method: Older adults with either age-normal hearing or mild-to-moderate sensorineural hearing loss performed a running memory task. Participants heard word strings of unpredictable length and at the end of each string were required to repeat back the final three words. Words were presented monaurally in telephone bandwidth (300 Hz to 3300 Hz) or expanded bandwidth (50 Hz to 7500 Hz), in quiet (65 dBZ SPL), or in white noise (65 dBZ SPL with noise at 60 dBZ SPL), with or without a visual display of the talker. Results: In quiet listening conditions, bimodal presentation increased the number of words correctly reported per trial but only for listeners with hearing loss and with high lipreading proficiency. Stimulus bandwidth did not affect performance. In noise, bimodal presentation and expanded bandwidth improved performance for all participant groups but did so by improving speech intelligibility, not by improving working memory. Conclusion: Expanded bandwidth and bimodal presentation can improve speech perceptibility in difficult listening conditions but may not always improve working memory performance. Application: Results can inform the design of telephone features to improve ease of communication for older adults.
Gender differences in stressors and reactions to stressors among Jordanian university students
Authors: Hamaideh Shaher H. 
Published: September 2010

Background: Stress among university students has been a topic of interest for researchers and teachers for many years because it affects not only their academic performance but also their physiological and psychological health. Male and female students perceive and react to stressors differently due to their differences in appraising stressful situations. Aims: The aims of this study were to examine differences in the perception of stressors and reactions to stressors between male and female Jordanian university students, and to identify the best predictors of stressors among them. Methods: Descriptive cross-sectional design was employed. The Student-Life Stress Inventory was used to measure stressors and reactions to stressors of 465 male and 485 female Jordanian university students recruited through stratified random sampling. Results: There were statistical differences between male and female students regarding their perception and reactions to stressors. Female students reported a higher perception of stressors in frustrations, conflict, pressures and changes, as well as emotional reactions to stressors. Male students reported higher behavioural and cognitive reactions to stressors than female students. Participation in stress workshops, perception of general health, and perception of stress level in general were found to predict stressors among male students, while mother’s educational level, perception of general health, and perception of stress level in general were found to predict stressors among female students. Conclusions: This study showed that gender differences in perception of stressors and reactions to stressors are similar to previous studies conducted all over the world. Interventions can be developed to help students better cope with stress. Conducting specific stress-training programmes for male and female students will help in reducing stress levels.
The role of self-esteem for outcome in first-episode psychosis
Authors: Vracotas Nadia , Iyer Srividya N. , Joober Ridha , Malla Ashok 
Published: September 2010

Background: Self-esteem may be associated with a wide range of psychiatric disorders, including psychotic disorders. However, the relationship between self-esteem and outcome in psychosis has not been adequately examined, especially early in the course of the illness. Aim: The aim of the study was to examine the impact of self-esteem in individuals who presented for treatment of a first episode of psychosis on outcome early in the course of the illness. Methods: The Self-Esteem Rating Scale (SERS) was administered to 121 individuals with first-episode psychosis following entry into a specialized programme. Symptoms and the Global Assessment of Functioning (GAF) were assessed at six months after beginning treatment. A correlational analysis was followed by a linear regression controlling for potential confounds. Results: Self-esteem assessed early in the course of treatment was positively correlated with GAF at six months ( r = 0.281, p < 0.01). A linear regression analysis conducted with GAF and depression at baseline in addition to gender, pre-morbid adjustment, duration of untreated psychosis (DUP), and self-esteem as predictors and GAF at six months as the outcome variable revealed only self-esteem to be a significant predictor of GAF at six months (β = 0.290, p < 0.01). However, no association was found between self-esteem and remission at six months (β = 0.003, p > 0.05). Conclusion: Self-esteem is associated with global functional outcome at six months but not with remission of symptoms. Efforts should be made to provide interventions that may improve low self-esteem in the attempt to influence functional outcome.
Use of extracorporeal life support to support patients with acute respiratory distress syndrome due to H1N1/2009 influenza and other respiratory infections
Authors: Wong Ivan , Vuylsteke Alain 
Published: September 2010

A large proportion of critically ill H1N1/2009 patients with respiratory failure subsequently developed ARDS and, to date, about 400 patients receiving extracorporeal life support (ECLS) have been accounted for globally, with a reported survival rate from 63% to 79%. The survival rates of patients with ARDS due to non-H1N1/2009 infections are similar. There is no definite evidence to suggest that patient outcomes are changed by ECLS, but its use is associated with serious short-term complications. ECLS relies on an extracorporeal circuit, with extracorporeal membrane oxygenation (ECMO) and pumpless interventional lung assist (ILA) being the two major types employed in ARDS. Both have the potential to correct respiratory failure and related haemodynamic instability. There are only a very limited number of clinical trials to test either and, although ECLS has been used in treating H1N1/2009 patients with ARDS with some success, it should only be offered in the context of clinical trials and in experienced centres.
A specific binding site for the prorenin propart peptide Arg10-Arg20 does not occur on human endothelial cells
Authors: Leckie Brenda J , Bottrill Andrew R 
Published: September 2010

Introduction. We looked for novel binding sites for the human prorenin ‘decoy peptide’ sometimes called ‘handle region peptide’ on human endothelial cells. Method. The biotinylated peptide biotin-Acp-RIFLKRMPSIR (B-PR), an unlabelled peptide PR1 (RIFLKRMPSIR) and a scrambled peptide scPR1 (SRRMIFPIKLR) were synthesized. B-PR was added to human umbilical cord endothelial cells (HUVECs) maintained in serum-free medium, with or without excess unlabelled peptide or ‘scrambled’ peptide as blocker. Biotin-labelled HUVEC proteins were extracted, the amount of bound tracer was measured, and the identity of the binding proteins was analysed by sodium-dodecyl-sulphate polyacrylamide gel electrophoresis (SDS-PAGE) and by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). Results. Biotinylated peptide bound to the HUVEC proteins with a major labelled band at 68,600 ± 1503 kDa (mean ± SEM, n=5 runs). Unlabelled peptide and scrambled peptide equally displaced the labelled peptide, indicating that the binding was non-specific for amino acid sequence. LC-MS/MS showed that binding was mainly to cytoskeletal proteins. Conclusion. The binding of the human prorenin peptide R10IFLKRMPSIR20 to HUVEC proteins is not specific for amino acid sequence and probably involves a general peptide/protein uptake mechanism. We could not detect a specific prorenin propart binding site in these cells.
Ready, willing and able? Specialist community public health nurses’ views of their public health role
Authors: Coverdale Gill 
Published: September 2010

This paper is a report of a research study to explore specialist community public health nurses’ views of their public health role. Three key objectives were set: to identify what their public health role was; to explore what the influences are on that role are; to investigate what they felt the solutions were to enhance this aspect of their role.The study design consisted of a small qualitative study that used three focus groups to collect data from practice teachers from health visiting, occupational health nursing and school nursing. The data was combined for thematic analysis of their responses to the three key topics identified. The results showed that the participants were somewhat knowledgeable about their role as public health nurses; were influenced by lack of resources, poor understanding from others of their role and tensions with managers and the wider team as to the importance of their public health role; and they offered solutions that included role clarity for effective skill mix, a shared vision for practice and debated the role of a specific public health nurse in the team. Recommendations for clear roles and responsibilities, clear protocols for assessing need and identifying priorities and performance management frameworks are offered.
Clinical Results and Functional Evaluation of the Chrisman-Snook Procedure for Lateral Ankle Instability in Athletes
Authors: Kramer Dennis , Solomon Ruth , Curtis Christine , Zurakowski David , Micheli Lyle J. 
Published: September 2010

There is no consensus regarding optimum surgical treatment for chronic ankle instability. The purpose of this study is to describe a variation of the Chrisman-Snook lateral ligament reconstruction that the senior author uses in patients with chronic ankle instability recalcitrant to conservative management. All patients who underwent reconstruction from 1997 to 2006 were identified, and those with a minimum 2-year follow-up were included, representing a total of 44 ankles in 43 patients. All underwent clinical evaluation and completion of the Foot and Ankle Outcome Survey and the Kaikkonen Scale. At mean follow-up of 4.4 years, mean dorsiflexion loss was 2° compared with the nonoperative side. The postoperative mean Foot and Ankle Outcome Survey score was 74 ± 16 (range, 36-98), while the mean Kaikkonen total score was 77 ± 14 (range, 40-95). Thirty-eight patients (84.6%) were satisfied with their result. Six patients (13.6%) underwent reoperation, including 4 with peroneal tendon scarring requiring tenolysis. Return to sport was achieved in 28 of 35 patients (80%) at a median of 6 months postoperatively. It is concluded that dorsiflexion loss can be minimized and return to sport expected in most patients following this variation of the Chrisman-Snook reconstruction. Levels of Evidence: Therapeutic, Level IV
Fancd2
−/− mice have hematopoietic defects that can be partially corrected by resveratrol
Authors: Zhang Qing-Shuo , Marquez-Loza Laura , Eaton Laura , Duncan Andrew W. , Goldman Devorah C. , Anur Praveen , Watanabe-Smith Kevin , Rathbun R. Keaney , Fleming William H. , Bagby Grover C. , Grompe Markus 
Published: September 2010

Abstract
Progressive bone marrow failure is a major cause of morbidity and mortality in human Fanconi Anemia patients. In an effort to develop a Fanconi Anemia murine model to study bone marrow failure, we found that Fancd2−/− mice have readily measurable hematopoietic defects. Fancd2 deficiency was associated with a significant decline in the size of the c-Kit+Sca-1+Lineage− (KSL) pool and reduced stem cell repopulation and spleen colony-forming capacity. Fancd2−/− KSL cells showed an abnormal cell cycle status and loss of quiescence. In addition, the supportive function of the marrow microenvironment was compromised in Fancd2−/− mice. Treatment with Sirt1-mimetic and the antioxidant drug, resveratrol, maintained Fancd2−/− KSL cells in quiescence, improved the marrow microenvironment, partially corrected the abnormal cell cycle status, and significantly improved the spleen colony-forming capacity of Fancd2−/− bone marrow cells. We conclude that Fancd2−/− mice have readily quantifiable hematopoietic defects, and that this model is well suited for pharmacologic screening studies.
Successful treatment of EBV-associated posttransplantation lymphoma after cord blood transplantation using third-party EBV-specific cytotoxic T lymphocytes
Authors: Barker Juliet N. , Doubrovina Ekaterina , Sauter Craig , Jaroscak Jennifer J. , Perales Miguel A. , Doubrovin Mikhail , Prockop Susan E. , Koehne Guenther , O'Reilly Richard J. 
Published: September 2010

Abstract
Cellular therapy of Epstein-Barr virus (EBV)+ posttransplantation lymphoproliferative diseases (PTLD) in cord blood transplant (CBT) recipients is limited by lack of donor access and the donor's naive neonatal immune system. We therefore used partially human leukocyte antigen–matched third-party in vitro expanded EBV-specific cytotoxic T lymphocytes (CTLs) to treat 2 CBT recipients with life-threatening, donor-derived monoclonal EBV+ diffuse large B-cell lymphomas with extranodal involvement developing in the context of graft-versus-host disease. Both patients had failed immunosuppression taper and Rituximab. After 5 and 9 infusions of 106 EBV-CTL/kg, respectively, each patient achieved a sustained complete remission without toxicity or graft-versus-host disease. Each is alive without recurrence at 20 and 15 months, respectively, post–EBV-PTLD diagnosis. This approach demonstrates the efficacy of using “off-the-shelf,” virus-specific third-party CTLs restricted by human leukocyte antigens expressed by the tumor to treat otherwise lethal EBV-PTLD. Such therapy may also be applicable to the treatment of other infections and residual or recurrent malignancy after CBT.
Detection, evaluation, and management of iron-restricted erythropoiesis
Authors: Goodnough Lawrence Tim , Nemeth Elizabeta , Ganz Tomas 
Published: September 2010

AbstractProgress in our understanding of iron-restricted erythropoiesis has been made possible by important advances in defining the molecular mechanisms of iron homeostasis. The detection and diagnostic classification of iron-restricted erythropoiesis can be a challenging process for the clinician. Newer assays for markers of inflammation may allow more targeted management of the anemia in these conditions. The availability of new intravenous iron preparations provides new options for the treatment of iron-restricted erythropoiesis. This review summarizes recent advances regarding the detection, evaluation, and management of iron-restricted erythropoiesis.
A PKA-Csk-pp60Src signaling pathway regulates the switch between endothelial cell invasion and cell-cell adhesion during vascular sprouting
Authors: Jin Hui , Garmy-Susini Barbara , Avraamides Christie J. , Stoletov Konstantin , Klemke Richard L. , Varner Judith A. 
Published: September 2010

AbstractAngiogenesis is controlled by signals that stimulate motility in endothelial cells at the tips of vascular sprouts while maintaining cell-cell adhesion in the stalks of angiogenic sprouts. We show here that Gs-linked G protein–coupled receptor activation of cAMP-dependent protein kinase (PKA) plays an important role in regulating the switch between endothelial cell adhesion and migration by activating C-terminal Src kinase, leading to inhibition of pp60Src. Activated PKA blocks pp60Src-dependent vascular endot helial-cadherin phosphorylation, thereby stimulating cell-cell adhesion while suppressing endothelial cell polarization, motility, angiogenesis, and vascular permeability. Similar to the actions of Notch and Dll4, PKA activation blocks sprouting in newly forming embryonic blood vessels, while PKA inhibition promotes excessive sprouting in these vessels. These findings demonstrate that G protein–coupled receptors and PKA regulate vascular sprouting during angiogenesis by controlling endothelial cell migration and cell-cell adhesion through their actions on pp60Src.
Mitochondrial genotype in vulvar carcinoma - cuckoo in the nest
Authors: Klemba Aleksandra , Kowalewska Magdalena , Kukwa Wojciech , Tonska Katarzyna , Szybinska Aleksandra , Mossakowska Malgorzata , Scinska Anna , Golik Paweł , Koper Kamil , Radziszewski Jakub , Kukwa Andrzej , Czarnecka Anna M , Bartnik Ewa 
Published: September 2010

AbstractVulvar squamous cell carcinoma (VSCC) is a rare female genital neoplasm. Although numerous molecular changes have been reported in VSCC, biomarkers of clinical relevance are still lacking. On the other hand, there is emerging evidence on the use of mtDNA as a diagnostic tool in oncology. In order to investigate mtDNA status in VSCC patients, haplogroup distribution analysis and D-loop sequencing were performed. The results were compared with available data for the general Polish population, cancer free-centenarians as well as patients with endometrial and head and neck cancer. The obtained data were also compared with the current status of mitochondrial databases. Significant differences in haplogroup distribution between VSCC cohort, general Polish population and cancer-free centenarians cohort were found. Moreover, a correlation between the VSCC patients haplogroup and HPV status was observed. Finally, a specific pattern of mtDNA polymorphisms was found in VSCC. Our results suggest that the mitochondrial genetic background may influence the risk of VSCC occurrence as well as susceptibility to HPV infection.
Transcriptional profile of maize roots under acid soil growth
Authors: Mattiello Lucia , Kirst Matias , da Silva Felipe R , Jorge Renato A , Menossi Marcelo 
Published: September 2010

AbstractBackgroundAluminum (Al) toxicity is one of the most important yield-limiting factors of many crops worldwide. The primary symptom of Al toxicity syndrome is the inhibition of root growth leading to poor water and nutrient absorption. Al tolerance has been extensively studied using hydroponic experiments. However, unlike soil conditions, this method does not address all of the components that are necessary for proper root growth and development. In the present study, we grew two maize genotypes with contrasting tolerance to Al in soil containing toxic levels of Al and then compared their transcriptomic responses.ResultsWhen grown in acid soil containing toxic levels of Al, the Al-sensitive genotype (S1587-17) showed greater root growth inhibition, more Al accumulation and more callose deposition in root tips than did the tolerant genotype (Cat100-6). Transcriptome profiling showed a higher number of genes differentially expressed in S1587-17 grown in acid soil, probably due to secondary effects of Al toxicity. Genes involved in the biosynthesis of organic acids, which are frequently associated with an Al tolerance response, were not differentially regulated in both genotypes after acid soil exposure. However, genes related to the biosynthesis of auxin, ethylene and lignin were up-regulated in the Al-sensitive genotype, indicating that these pathways might be associated with root growth inhibition. By comparing the two maize lines, we were able to discover genes up-regulated only in the Al-tolerant line that also presented higher absolute levels than those observed in the Al-sensitive line. These genes encoded a lipase hydrolase, a retinol dehydrogenase, a glycine-rich protein, a member of the WRKY transcriptional family and two unknown proteins.ConclusionsThis work provides the first characterization of the physiological and transcriptional responses of maize roots when grown in acid soil containing toxic levels of Al. The transcriptome profiles highlighted several pathways that are related to Al toxicity and tolerance during growth in acid soil. We found several genes that were not found in previous studies using hydroponic experiments, increasing our understanding of plant responses to acid soil. The use of two germplasms with markedly different Al tolerances allowed the identification of genes that are a valuable tool for assessing the mechanisms of Al tolerance in maize in acid soil.