bluuebunny/crossref_metadata_2025_split huggingface dataset:
Religion and spirituality
Authors: Worthington Everett L. , Hook Joshua N. , Davis Don E. , McDaniel Michael A. 
Published: November 2010

AbstractMany clients highly value religious and spiritual (R/S) commitments, and many psychotherapists have accommodated secular treatments to R/S perspectives. We meta‐analyzed 51 samples from 46 studies (N = 3,290) that examined the outcomes of religious accommodative therapies and nonreligious spirituality therapies. Comparisons on psychological and spiritual outcomes were made to a control condition, an alternate treatment, or a subset of those studies that used a dismantling design (similar in theory and duration of treatment, but including religious contents). Patients in R/S psychotherapies showed greater improvement than those in alternate secular psychotherapies both on psychological (d =.26) and on spiritual (d = .41) outcomes. Religiously accommodated treatments outperformed dismantling‐design alternative treatments on spiritual (d = .33) but not on psychological outcomes. Clinical examples are provided and therapeutic practices are recommended. © 2010 Wiley Periodicals, Inc. J Clin Psychol: In Session 67:204–214, 2011.
A hybrid model of social phobia: an analysis of social anxiety and related symptoms of anxiety
Authors: Gros Daniel F. , Simms Leonard J. , Antony Martin M. 
Published: November 2010

AbstractThe categorical underpinnings of the current diagnostic nomenclature have been the subject of repeated criticism. Recently, researchers have proposed several alternatives to the current system, including hybrid models of combined diagnostic categories and symptom dimensions. In the present study, we investigated the symptoms associated with a hybrid model of social phobia. The study included (a) the development of the initial set of symptom dimensions, generation of an item pool, and review by an expert panel, and (b) data collection and component analysis of the item pool to determine the structure of the symptoms. Six separate theoretically relevant symptom dimensions were identified. Implications of these findings on the development of a new hybrid model of social phobia were discussed. © 2010 Wiley Periodicals, Inc. J Clin Psychol 00:1–15, 2010.
A novel targeting modality for renal cell carcinoma: human osteocalcin promoter‐mediated gene therapy synergistically induced by vitamin C and vitamin D3
Authors: Johnson Nicole A. , Chen Bing‐Hung , Sung Shian‐Ying , Liao Chia‐Hui , Hsiao Wan‐Chi , W. K. Chung Leland , Hsieh Chia‐Ling 
Published: November 2010

AbstractBackgroundAdvanced renal cell carcinoma (RCC) frequently develops skeletal metastasis and is highly resistant to conventional therapies. We hypothesized that the osteocalcin (OC) promoter may be a promising gene delivery system for RCC targeted gene therapy because osteotropic tumors gain osteomimetic properties and thrive in the new environment by exhibiting a bone‐like gene expression profile. Human OC (hOC) expression is highly regulated by vitamins and hormone. In the present study, we tested the feasibility of vitamin‐regulatable hOC promoter for RCC‐specific transcriptional targeting, and examined the anti‐tumor effect of vitamins C and D3with hOC‐based adenoviral vectors towards RCC.MethodsReal‐time reverse transcriptase‐polymerase chain reaction measured OC expression induced by vitamins C and D3, either alone or in combination, in RCC and normal human renal epithelial cells (HRE). The RCC‐cytotoxic effects of concomitant vitamins and hOC promoter‐based adenoviral vectors, Ad‐hOC‐TK and Ad‐hOC‐E1, were evaluated in both cell culture and a xenograft murine model.ResultsWe found that high doses of vitamin C induced H2O2‐dependent apoptosis in RCC but not HRE. Treatment of RCC cells with combined vitamins C and D3treatment significantly increased OC promoter activity compared to single reagent treatment. Combined vitamin therapy reduced tumor size (85%) and complete tumor regression occurred in 38% of mice co‐administrated Ad‐hOC‐E1.ConclusionsThe results obtained in the present study demonstrate that vitamins C and D3synergized with the anti‐tumor effects of therapeutic genes driven by hOC promoter through direct cytotoxicity as well as transcriptional targeting. This combined gene therapy provides a promising modality for advanced RCC targeted therapy. Copyright © 2010 John Wiley & Sons, Ltd.
The ciliary smooth muscle electrotransfer: basic principles and potential for sustained intraocular production of therapeutic proteins
Authors: Touchard Elodie , Kowalczuk Laura , Bloquel Carole , Naud Marie‐Christine , Bigey Pascal , Behar‐Cohen Francine 
Published: November 2010

AbstractBackgroundWe have developed a nonviral gene therapy method based on the electrotransfer of plasmid in the ciliary muscle. These easily accessible smooth muscle cells could be turned into a biofactory for any therapeutic proteins to be secreted in a sustained manner in the ocular media.MethodsElectrical conditions, design of electrodes, plasmid formulation, method and number of injections were optimized in vivo in the rat by localizing β‐galactosidase expression and quantifying reporter (luciferase) and therapeutic (anti‐tumor necrosis factor) proteins secretion in the ocular media. Anatomical measurements were performed via human magnetic resonance imaging to design a human eye‐sized prototype that was tested in the rabbit.ResultsIn the rat, transscleral injection of 30 µg of plasmid diluted in half saline (77 mM NaCl) followed by application of eight square‐wave electrical pulses (15 V, 10 ms, 5.3 Hz) using two platinum/iridium electrodes, an internal wire and an external sheet, delivered plasmid efficiently to the ciliary muscle fibers. Gene transfer resulted in a long‐lasting (at least 5 months) and plasmid dose‐/injection number‐ dependent secretion of different molecular weight proteins mainly in the vitreous, without any systemic exposure. Because ciliary muscle anatomical measurements remained constant among ages in adult humans, an integrated device comprising needle‐electrodes was designed and manufactured. Its usefulness was validated in the rabbit.ConclusionsPlasmid electrotransfer to the ciliary muscle with a suitable medical device represents a promising local and sustained protein delivery system for treating posterior segment diseases, avoiding repeated intraocular injections. Copyright © 2010 John Wiley & Sons, Ltd.
Transplantation of CTLA4Ig gene‐transduced adipose tissue‐derived mesenchymal stem cells reduces inflammatory immune response and improves Th1/Th2 balance in experimental autoimmune thyroiditis
Authors: Choi Eun Wha , Shin Il Seob , Lee Hee Woo , Park So Young , Park Ji Hyun , Nam Mi Hyun , Kim Jong Sung , Woo Sang Kyu , Yoon Eun Ji , Kang Sung Keun , Ra Jeong Chan , Youn Hwa Young , Hong Sung Hwa 
Published: November 2010

AbstractBackgroundAutoimmune thyroiditis is one of common organ‐specific autoimmune disease. The aim of this study was to observe the effect of adipose tissue derived mesenchymal stem cells (ATMSC) and CTLA4Ig gene‐transduced ATMSC on autoimmune thyroiditis.MethodsExperimental autoimmune thyroiditis was induced by immunization with thyroglobulin. Animals were divided into three groups: (i) a half million of human ATMSC, (ii) a half million of murine CLTA4Ig gene‐transduced human ATMSC (CTLA4Ig‐MSC), or (iii) normal saline (as control), which were administered intravenously four times within a 3‐week period. Blood and tissue samples were collected 1 week after the last cell transplantation.ResultsThe absorbance of serum thyroglobulin autoantibody (TgAA) in the CTLA4Ig‐MSC group was considerably lower than those in other groups. In culture supernatant of LPS‐stimulated spleen cells, both of the MSC‐treated groups showed significantly lower absorbances of TgAA than the control. Flow cytometric analysis of spleen cells revealed a significant decrease in the proportion of CD3+ and CD11b in the CTLA4Ig‐MSC group compared to the other groups. Lymphocyte infiltration in the thyroid glands was also dramatically decreased in both of MSC‐treated groups. Cytokine analysis showed that ATMSC decreased the production of proinflammatory cytokines and improved the Th1/Th2 balance by down‐regulating Th1 cytokines.ConclusionAlthough CTLA4Ig‐MSC transplantation had better result in reduction of serum TgAA, both of ATMSC and CTLA4Ig‐MSC transplantations are promising treatments for autoimmune thyroiditis judging from the results of histopathology and cytokine analysis. They may be attractive candidates for treating organ‐specific autoimmune disease. Copyright © 2011 John Wiley & Sons, Ltd.
Imaging of the pleura
Authors: Helm Emma J. , Matin Tahreema N. , Gleeson Fergus V. 
Published: November 2010

AbstractPleural disease is a problem of global significance which causes significant morbidity and mortality. Pleural disease is usually first suspected on chest x‐ray but further imaging, often ultrasound, is usually required as part of the diagnostic work‐up. Complex imaging with computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET)‐CT are less often performed but are routinely required in patients with mesothelioma and occasionally required in patients with pleural infection and other pleural diseases. Cross‐sectional imaging may be used to suggest the diagnosis of pleural disease, quantify disease severity, guide biopsy, and even predict prognosis. This review will focus on the contributions of CT, MRI, and PET to the management of pleural disease with discussion of their relative strengths and weaknesses. J. Magn. Reson. Imaging 2010;32:1275–1286. © 2010 Wiley‐Liss, Inc.
Imaging phenotypes of chronic obstructive pulmonary disease
Authors: Ley‐Zaporozhan Julia , van Beek Edwin J.R. 
Published: November 2010

AbstractChronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide. COPD is defined by irreversible airflow obstruction. It is a heterogeneous disease affecting the airways and/or the parenchyma with different severity during the course of the disease. These different aspects of COPD can be addressed by imaging using a combination of morphological and functional techniques. Computed tomography (CT) is the technique of choice for morphological imaging of the lung parenchyma and airways. This morphological information is to be accomplished by functional information about ventilation and perfusion, mainly provided by magnetic resonance imaging (MRI). The comprehensive diagnostic possibilities of CT complemented by MRI will allow for a more sensitive detection, phenotype‐driven characterization, and dedicated therapy monitoring of the disease. J. Magn. Reson. Imaging 2010;32:1340–1352. © 2010 Wiley‐Liss, Inc.
Computed tomography and magnetic resonance imaging of mediastinal tumors
Authors: Takahashi Koji , Al‐Janabi Nabaa Jaba 
Published: November 2010

AbstractWe describe the clinical, pathological, and imaging findings of mediastinal tumors with focus on thymic hyperplasia, thymic epithelial tumors, and germ cell tumors, malignant lymphoma, and various cystic masses. Chemical shift magnetic resonance imaging (MRI) is useful in characterization of the normal thymus and differentiation of hyperplastic thymus and thymic tumors. In contrast to noninvasive thymomas, invasive thymomas and thymic carcinomas show a more aggressive growth pattern. Local invasion and pleural spread are characteristic of invasive thymoma and mediastinal lymphadenopathy and distant metastasis suggest thymic carcinomas. Mature teratoma typically shows various computed tomography (CT) attenuation, and MR signal intensity depending on its contents and fat tissue and bone within the lesions are its characteristic findings. Seminomas typically have homogenous internal CT attenuation and MR signal intensity with minimal contrast enhancement. Nonseminomatous malignant germ cell tumors characteristically show prominent internal degenerative changes and invasion to the adjacent structures. In mediastinal lymphomas, a residual mass is common after treatment and MRI provides important information in distinguishing viable tumors from residual benign masses. Some mediastinal cysts may reveal high attenuation similar to solid lesions on CT depending on their contents and MRI can be useful in the differentiation of cystic masses from solid lesions. J. Magn. Reson. Imaging 2010;32:1325–1339. © 2010 Wiley‐Liss, Inc.
Lung perfusion measured using magnetic resonance imaging: New tools for physiological insights into the pulmonary circulation
Authors: Hopkins Susan R. , Prisk G. Kim 
Published: November 2010

AbstractSince the lung receives the entire cardiac output, sophisticated imaging techniques are not required in order to measure total organ perfusion. However, for many years studying lung function has required physiologists to consider the lung as a single entity: in imaging terms as a single voxel. Since imaging, and in particular functional imaging, allows the acquisition of spatial information important for studying lung function, these techniques provide considerable promise and are of great interest for pulmonary physiologists. In particular, despite the challenges of low proton density and short T2* in the lung, noncontrast MRI techniques to measure pulmonary perfusion have several advantages including high reliability and the ability to make repeated measurements under a number of physiologic conditions. This brief review focuses on the application of a particular arterial spin labeling (ASL) technique, ASL‐FAIRER (flow sensitive inversion recovery with an extra radiofrequency pulse), to answer physiologic questions related to pulmonary function in health and disease. The associated measurement of regional proton density to correct for gravitational‐based lung deformation (the “Slinky” effect (Slinky is a registered trademark of Pauf‐Slinky incorporated)) and issues related to absolute quantification are also discussed. J. Magn. Reson. Imaging 2010;32:1287–1301. © 2010 Wiley‐Liss, Inc.
Magnetic resonance imaging and computed tomography developments in imaging of venous thromboembolism
Authors: van Langevelde Kirsten , Tan Melanie , Šrámek Alexandr , Huisman Menno V. , de Roos Albert 
Published: November 2010

AbstractVenous thromboembolism (VTE) is a disease that causes high morbidity and mortality in the population. At present the first‐line imaging test for a suspected pulmonary embolism (PE) is computed tomography (CT) pulmonary angiography, and ultrasonography is widely used for the diagnosis of deep‐vein thrombosis (DVT). Although these modalities are proven to be safe and accurate, unresolved issues remain, such as whether CT scanning in patients with a suspected PE should be extended to the legs. Another issue is the diagnosis of recurrent DVT. Magnetic resonance imaging (MRI) offers a number of advantages in the imaging of VTE. Recent developments of scanning protocols with shorter acquisition times, sometimes complemented by navigator gating or making use of endogenous contrast, offer new perspectives for the use of MRI. This review provides an overview of state of the art MRI techniques for the diagnosis of PE and DVT. Furthermore, the use of new contrast agents such as fibrin labeling to detect thrombi are addressed. J. Magn. Reson. Imaging 2010;32:1302–1312. © 2010 Wiley‐Liss, Inc.
Image‐based modeling of lung structure and function
Authors: Tawhai Merryn H. , Lin Ching‐Long 
Published: November 2010

AbstractThe current state‐of‐the‐art in image‐based modeling allows derivation of patient‐specific models of the lung, lobes, airways, and pulmonary vascular trees. The application of traditional engineering analyses of fluid and structural mechanics to image‐based subject‐specific models has the potential to provide new insight into structure–function relationships in the individual via functional interpretation that complements imaging and experimental studies. Three major issues that are encountered in studies of airflow through the bronchial airways are the representation of airway geometry, the imposition of physiological boundary conditions, and the treatment of turbulence. Here we review some efforts to resolve each of these issues, with particular focus on image‐based models that have been developed to simulate airflow from the mouth to the terminal bronchiole, and subjected to physiologically meaningful boundary conditions via image registration and soft‐tissue mechanics models. J. Magn. Reson. Imaging 2010;32:1421–1431. © 2010 Wiley‐Liss, Inc.
Multimodality molecular imaging of the lung
Authors: Chen Delphine L. , Kinahan Paul E. 
Published: November 2010

AbstractThe continued progression of chronic lung disease despite current treatment options has led to the increasing evaluation of molecular imaging tools for diagnosis, treatment planning, drug discovery, and therapy monitoring. Concurrently the development of multimodality positron emission tomography (PET) / computed tomography (CT), single‐photon emission computed tomography (SPECT)/CT, and magnetic resonance imaging (MRI)/PET scanners has opened the potential for more sophisticated imaging biomarker probes. Here we review the potential uses of multimodality imaging tools, the established uses of molecular imaging in nononcologic lung pathophysiology and drug discovery, and some of the technical challenges in multimodality molecular imaging of the lung. J. Magn. Reson. Imaging 2010;32:1409–1420. © 2010 Wiley‐Liss, Inc.
Demonstration of the heterogeneous distribution of asthma in the lungs using CT and hyperpolarized helium‐3 MRI
Authors: Aysola Ravi , de Lange Eduard E. , Castro Mario , Altes Talissa A. 
Published: November 2010

AbstractAsthma is a chronic inflammatory disease that affects both the large and small airways and results in bronchoconstriction, mucous hypersecretion, smooth muscle hypertrophy, and subepithelial fibrosis. To gain insight into the pathophysiology of asthma, chest computed tomography (CT) has been investigated as a noninvasive method to evaluate airway wall thickness of medium and large airways. Hyperpolarized gas MRI can assess the functional alterations of airflow within the lung resulting from the structural changes in the airways. In this article, we review the application of CT‐based techniques and hyperpolarized gas MRI to study structural and functional changes in asthma. From the result of studies with CT and hyperpolarized gas MRI, it is becoming apparent that asthma has a regional distribution within the lung, that is, some areas of the lung are more affected than others. Furthermore, there appears to be some persistence to this distribution which may explain the observed patterns of airway remodeling and provide targets for localized therapies such as local application of anti‐inflammatory agents or bronchial thermoplasty. Thus, cross sectional imaging in asthma is providing new insights into the pathophysiology of the disease and has the potential to become essential in the guidance of localized treatments. J. Magn. Reson. Imaging 2010;32:1379–1387. © 2010 Wiley‐Liss, Inc.
A matched case–control study of hepatitis B virus mutations in the preS and core promoter regions associated independently with hepatocellular carcinoma
Authors: Liu Shijian , Xie Jiaxin , Yin Jianhua , Zhang Hongwei , Zhang Qi , Pu Rui , Li Chengzhong , Ni Wu , Wang Hongyang , Cao Guangwen 
Published: November 2010

AbstractThis study aimed to determine hepatitis B virus (HBV) mutations associated independently with the risk of hepatocellular carcinoma (HCC), as adjusted with other mutations in the preS and core promoter regions of HBV genotypes B and C. One hundred and forty HBV‐infected patients with HCC and 280 HBV‐infected patients without HCC who had intact data of HBV genotyping and DNA sequencing in both regions were involved in this age‐, sex‐matched case–control study. Univariate and two‐step stepwise multivariate regression analyses were performed to determine factors associated with the risk of HCC. Of 39 mutations evaluated, 23 in genotype C and 6 in genotype B were associated with an increased risk of HCC in the univariate analysis. Multivariate analyses established that genotype C (adjusted odds ratio [AOR] = 3.3; 95% confidence interval [CI] = 1.1–9.8), viral load (≥104 copies/ml) (AOR = 2.4; 95% CI = 1.0–5.8), A2962G (AOR = 18.7; 95% CI = 7.5–46.7), preS2 start codon mutation (AOR = 12.5; 95% CI = 3.4–45.5), C105T (AOR = 0.1; 95% CI = 0.0–0.2), T1753V (AOR = 3.1; 95% CI = 1.1–9.2), and A1762T/G1764A (AOR = 2.9; 95% CI = 1.1–7.3) were associated independently with HCC, adjusted for factors including mutations in both regions. By using an estimating haplotype frequencies program, it was found that a haplotypic carriage with 105C and 2962G was significantly more frequent in the patients with HCC than in those without HCC and the frequency of haplotype 2962G‐preS2 start codon wildtype‐105C‐1762T/1764A was 47.9% in the patients with HCC and 4.3% in those without HCC. Conclusively, A2962G and T105C are novel factors associated independently with HCC. Further prospective studies are needed to confirm the role of these mutations in the development of HCC. J. Med. Virol. 83:45–53, 2011. © 2010 Wiley‐Liss, Inc.
Clinical and molecular characterization of a parechovirus type 1 outbreak in neonates in Croatia
Authors: Ljubin‐Sternak Sunčanica , Juretić Emilja , Šantak Maja , Pleša Mirna , Forčić Dubravko , Vilibić‐Čavlek Tatjana , Aleraj Borislav , Mlinarić‐Galinović Gordana 
Published: November 2010

AbstractDuring July 2009 an outbreak in neonates represented with gastrointestinal and respiratory symptoms was observed at the Neonatal Postintensive Care Unit, Clinical Hospital Center, Zagreb. Human parechovirus type 1 (HPeV1) was isolated from seven patients, one of whom was asymptomatic. All but one were premature neonates with serious underlying conditions, and all recovered fully after several days. In order to characterize the HPeV1s, sequencing of the VP1/2A region was conducted on six isolates from the outbreak and four isolates detected in Croatia in 2008 and 2007. The analysis of sequence similarity showed that the nucleotide identity between the prototype strain (Harris) and HPeV1 isolated in Croatia was 76.5–77.5%. Croatian strains from 2007 and 2009 clustered together with strains from the Netherlands and Germany detected in 2003 and 2006, respectively, while strains from 2008 clustered with the strain from Finland detected in 2000. Change of the dominant strains each year may suggest antigenic variation as a result of viral response to specific immunity of the target population. J. Med. Virol. 83:137–141, 2011. © 2010 Wiley‐Liss, Inc.