bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Language of Muslim Universality
Authors: Devji Faisal 
Published: July 2011

AbstractThis paper discusses how it is possible to find, in the Islamic tradition, a universal concept of “humanity”. It insists on the concept of “ ummah” as a peculiar muslim way to define a comprehensive humanity, and try to point out its internal limits. It shows the communal implication of this concept and the ways it can, or cannot, be considered as constitutive of a we-group concept that may eventually lead to conflict and violence. It brings to the attention of the reader some historical examples, focusing, among others, on mohammad Iqbal’s contribution.
Antibodies associated with heparin-induced thrombocytopenia (HIT) inhibit activated protein C generation: new insights into the prothrombotic nature of HIT
Authors: Kowalska M. Anna , Krishnaswamy Sriram , Rauova Lubica , Zhai Li , Hayes Vincent , Amirikian Karine , Esko Jeffrey D. , Bougie Daniel W. , Aster Richard H. , Cines Douglas B. , Poncz Mortimer 
Published: July 2011

AbstractHeparin-induced thrombocytopenia (HIT) is caused by antibodies that recognize complexes between platelet factor 4 (PF4) and heparin or glycosaminoglycan side chains. These antibodies can lead to a limb- and life-threatening prothrombotic state. We now show that HIT antibodies are able to inhibit generation of activated protein C (aPC) by thrombin/thrombomodulin (IIa/TM) in the presence of PF4. Tetrameric PF4 potentiates aPC generation by formation of complexes with chondroitin sulfate (CS) on TM. Formation of these complexes occurs at a specific molar ratio of PF4 to glycosaminoglycan. This observation and the finding that the effect of heparin on aPC generation depends on the concentration of PF4 suggest similarity between PF4/CS complexes and those that bind HIT antibodies. HIT antibodies reduced the ability of PF4 to augment aPC formation. Cationic protamine sulfate, which forms similar complexes with heparin, also enhanced aPC generation, but its activity was not blocked by HIT antibodies. Our studies provide evidence that complexes formed between PF4 and TM's CS may play a physiologic role in potentiating aPC generation. Recognition of these complexes by HIT antibodies reverses the PF4-dependent enhancement in aPC generation and may contribute to the prothrombotic nature of HIT.
An open-label, pilot study of fludarabine, cyclophosphamide, and alemtuzumab in relapsed/refractory patients with B-cell chronic lymphocytic leukemia
Authors: Montillo Marco , Tedeschi Alessandra , Petrizzi Valeria Belsito , Ricci Francesca , Crugnola Monica , Spriano Mauro , Spedini Pierangelo , Ilariucci Fiorella , Uziel Lilj , Attolico Immacolata , Vismara Eleonora , De Blasio Angelo , Zaccaria Alfonso , Morra Enrica 
Published: July 2011

Abstract
Although combination regimens have improved outcomes over monotherapy in chronic lymphocytic leukemia (CLL), patients eventually relapse. Combined fludarabine, cyclophosphamide, and monoclonal anti-CD52 antibody alemtuzumab (FCC) provided synergistic cytotoxicity with effective clearing of minimal residual disease. This phase 2 study determined FCC efficacy and safety in relapsed/refractory CD52+ B-CLL after ≥ 1 line of treatment. From January 2005 through June 2008, up to 6 courses of oral fludarabine 40 mg/m2 per day, oral cyclophosphamide 250 mg/m2 per day, and subcutaneous alemtuzumab (Mab-Campath) 10 mg (increased to 20 mg after first 10-patient cohort) were administered days 1 to 3 every 28 days. The primary objective was overall response rate (ORR); secondary objectives included response duration, time to disease progression, and safety and tolerability. ORR was 67% in 43 patients; 30% achieved complete response. ORR significantly improved with 1 versus ≥ 2 prior therapies (P = .018), and without versus with previous monoclonal antibody treatment (P = .003). Median progression-free survival was 24.4 months, not reached in patients achieving complete response. Median overall survival was 33.6 months. Myelosuppression was the most common adverse event, with a low percentage of cytomegalovirus reactivations and manageable infections. However, close vigilance of opportunistic infections is warranted. FCC provides effective immunotherapy in relapsed/refractory CLL, including in patients with poor-risk prognostic factors.
An interaction between Nrf2 polymorphisms and smoking status affects annual decline in FEV1: a longitudinal retrospective cohort study
Authors: Masuko Hironori , Sakamoto Tohru , Kaneko Yoshiko , Iijima Hiroaki , Naito Takashi , Noguchi Emiko , Hirota Tomomitsu , Tamari Mayumi , Hizawa Nobuyuki 
Published: July 2011

AbstractBackgroundAn Nrf2-dependent response is a central protective mechanism against oxidative stress. We propose that particular genetic variants of theNrf2gene may be associated with a rapid forced expiratory volume in one second (FEV1) decline induced by cigarette smoking.MethodsWe conducted a retrospective cohort study of 915 Japanese from a general population. Values of annual decline in FEV1were computed for each individual using a linear mixed-effect model. Multiple clinical characteristics were assessed to identify associations with annual FEV1decline. Tag single-nucleotide polymorphisms (SNPs) in theNrf2gene (rs2001350, rs6726395, rs1962142, rs2364722) and one functional SNP (rs6721961) in theNrf2promoter region were genotyped to assess interactions between theNrf2polymorphisms and smoking status on annual FEV1decline.ResultsAnnual FEV1decline was associated with smoking behavior and inversely correlated with FEV1/FVC and FEV1% predicted. The mean annual FEV1declines in individuals with rs6726395 G/G, G/A, or A/A were 26.2, 22.3, and 20.8 mL/year, respectively, and differences in these means were statistically significant (pcorr= 0.016). We also found a significant interaction between rs6726395 genotype and smoking status on the FEV1decline (p for interaction = 0.011). The haplotype rs2001350T/rs6726395A/rs1962142A/rs2364722A/rs6721961T was associated with lower annual decline in FEV1(p = 0.004).ConclusionsThis study indicated that an Nrf2-dependent response to exogenous stimuli may affect annual FEV1decline in the general population. It appears that the genetic influence ofNrf2is modified by smoking status, suggesting the presence of a gene-environment interaction in accelerated decline in FEV1.
Note sur les tests de rationalité des prévisions
Authors: Doz Catherine 
Published: July 2011

Die verzerrten Prognosetests,
von Catherine Doz.

In diesem Artikel wird der Grundsatz der verzerrten Prognosetests erörtert und die damit verbundene Schwierigkeit aufgezeigt. Aufgrund der geringen Anzahl der untersuchten Aspekte ist tatsächlich bei der Analyse dieser Testergebnisse allerdings Vorsicht oft geboten.
Choix éducatifs, équilibre général et croissance économique
Authors: d'Autume Antoine 
Published: July 2011

Opciones educativas,equilibrio general y crecimiento económico,
por Antoine d'Autume.

Dar cuenta de la función que ocupa el capital humano en el crecimiento económico requiere un marco de análisis unificado que integre los comportamientos educativos de nivel microeconómico en un modelo de equilibrio general. Demostramos que un modelo plurigeneracional escrito en tiempo contínuo, permite describir mejor un comportamiento de ciclo de vida y provee un marco adecuado, en el que la problemática de la existencia de un crecimiento endógeno encuentra naturalmente una vía de respuesta. Retomamos luego una versión del modelo de Lucas (1988) para analizar el desempeño de las políticas educativas.
Glanum préromaine : recherche sur la métrologie et ses applications dans l'urbanisme et l'architecture
Authors: Roth-Congès Anne 
Published: July 2011

A metrological study of various types of Hellenistic remains at Glanum, carried out with the help of appropriate methods (measurements of the consecutive heights of architectonic elements and small monuments, surveying houses and public buildings, superimposition of grids onto photogrammetric map) revealed the existence of a "Glanic foot", a unit of measurement which was perhaps indigenous to this region, measuring 28.5 cm. This foot was a basic unit of the Hellenic-type metrological System. Its multiples were the brasse or orgye (equal to 6 feet), the amma (60 feet), and its submultiple, the dactyle (1/16 foot). The décimal System was used concurrently for the multiples of the dactyle and the foot.
In each quarter of the Antique agglomeration uncovered so far according to pre-selected plans established to reveal the spatial organization and the chronological succession of the remains, the existence of a grid pattern with units measuring 1 amma could be recognized despite topographie and urbanistic constraints. These units generally allowed for the presence of one dwelling and contiguous roadways.
The metrological study of monuments helps, in the best of cases, to reconstitute them and, sometimes, to define the origin of architectonic elements whose source is uncertain. The translation into Antique measurements of height, moreover, facilitates comparisons at whatever the scale, revealing constants and modules. Finally, over and above the concrete contribution made to archeology, a metrological study sheds its own special light on the much debated problem of the vitality of indigenous traditions and their dialectical relationship with external influences.
Découverte d'une inscription à un préteur quattuorvir à l'oppidum de Saint-Vincent à Gaujac (Gard)
Authors: Charmasson Jean 
Published: July 2011

The oppidum of Saint Vincent in the commune of Gaujac (Gard) became a sanctuary of the city of the Volques Arécomiques during the reign of Augustus. Research has already contributed toward the discovery there of three temples, public baths containing a place of prayer, and an urban parapet.
The discovery of a lapidary inscription in the baths to a Lender Quattuorvir attests to the quality of the relationships between the sanctuary and the Colony of Nîmes.
On a support of fine gray limestone, the inscription was resting on the ground of a low terrace which seemed to serve as a place to deposit offerings at the northern end of the entrance courtyard to the baths. The stone, incomplète, broken violently, bears the following inscription: PATER... / PRAE... / lui VIR. It could be read as follows: PATER[NUS] / PRAE[TO] / lui VIR. The first two lines are incomplète at the right ends. This inscription was probably on the pedestal of a statue.
It can be dated between the construction of the baths in the middle of the lst century and the first years of the 3rd century when they were abandoned.
Le problème de la diffusion des céramiques ibériques peintes dans le Sud de la Gaule au IIe et au Ier s. av. J.-C. L'exemple de Ruscino
Authors: Guérin P. 
Published: July 2011

Les céramiques ibériques recueillies dans le sud de la Gaule se répartissent en deux groupes. D'une part, la production locale archaïque du VIe et du Ve s. avant J.-C. nommée ibéro-languedocienne, d'autre part, les séries de sombrero de copa et de plats, importées de Catalogne durant le IIe et le Ie s. avant J.-C Les collections importantes, comme celle de Ruscino, permettent d'observer les détails de la forme et du décor qui traduisent une modification dans les modes de production des ateliers à céramique de la Nouvelle Catalogne à partir du début du IIe s. avant J.-C.
Ces faits sont en rapport avec la conquête romaine en péninsule Ibérique, et surtout avec la proximité de Tarragone, capitale d'Espagne Citérieure, qui a probablement joué un rôle dans la diffusion des céramiques locales en Gaule méridionale.
Un four à tuiles du Ier s. ap. J.-C. à Saint-Maurice-de-Ventalon (Lozère)
Authors: Dardaine Sylvie , Waton Marie Dominique 
Published: July 2011

A Saint-Maurice-de-Ventalon (Lozère), à la limite de la cité des Gabales et de celle des Volques Arécomiques a été mis au jour un four à tuiles qui appartenait à un atelier dépendant d'une villa ou d'une mansio.
Du four construit en schiste, il ne subsiste que les parties qui étaient enterrées dans l'Antiquité. La chambre de chauffe quadrangulaire était constituée d'un canal central et de conduits secondaires obliques, ménagés entre les six arceaux qui soutenaient la sole, aujourd'hui disparue. Sous le dallage du canal central un drain permettait d'évacuer les eaux d'infiltration. Construit sous Tibère, le four cessa toute activité vers 70 après J.-C.
La montagne Sainte-Victoire de la Préhistoire à la fin de l'Antiquité : les rythmes de l'occupation humaine (prospection-inventaire 1989-1992)
Authors: Anna André d' , Leveau Philippe , Mocci Florence 
Published: July 2011

A. D'Anna, Ph. Leveau and F. Mocci. — The Sainte Victoire mountain, from the prehistory until the end of antiquity : the rythms of human occupation (prospectings and inventory), Revue Archéologique de Narbonnaise, t. 25, 1992, p. 265-299.
After the fire of 1989, prospectings were carried out on the whole massif of the Sainte Victoire mountain, and since they were done in a diachronic way they allowed to review all the known sites and to identify new ones. A particular attention was given to the interpretation of the site in a research about its environment : what does it tell us on the state of the massif at the time men occupied it ? How was daily life assured ? Therefore a most peculiar attention was given to the agricultural systems. Such an appraisal was necessary to be given to both paleo-environmentalists who work on the same space and to archeologists who prepare the excavations.
Des prospections à la fouille : recherches à Eyguières (B.-du-R.)
Authors: Pelletier Jean-Pierre , Poguet Michel , Brien-Poitevin Françoise , Lafaurie Jean , Rigoir Yves , Rigoir Jacqueline 
Published: July 2011

A first part introduces the synthesis of prospectings carried out systematically for fifteen years on the territory of Eyguières and on its direct surroundings. The assessment of about ninety listed sites and newly discovered equipment concerns all the epochs, from prehistory — thirty sites from the middle Neolithic to the Iron Age — until the Middle Ages. Eight archeological maps relate the development of the human settlement allocation on the long term. The numerous discoveries allow, first to be more specific regarding the division of this land during the Gallo Roman epoch between large properties and small farms, second to link them to centuriations and third to handle the steady occupation during late Antiquity and early Middle Ages.
The second part recalls the salvage excavation carried out on one of the major sites i.e a villa dating back to the late Empire where the balneum — which had been rebuilt between the end of the 4th and the beginning of the 5 th century and which is very well preserved — has been occupied once more from the 6th century to the eve of the year one thousand. A study of the discovered ceramic, conchyliogical and money items concerning those epochs still poorly known in this region, completes the description of the remains.
Seuils de pierre en Gaule méridionale : l'exemple d'Olbia (Hyères, Var)
Authors: Bouet Alain 
Published: July 2011

The typological and chronological study of the thresholds of the Olbia site (Hyères-les-Palmiers, Var) allowed to individualise four major categories : the thresholds without rabbet, the thresholds with broad step, the thresholds with narrow step and running groove.
The chronological information of the excavations from Olbia or from other numerous sites in southern Gaul have allowed to define an
evolution between broad step and narrow step thresholds.
Structural Diversity of Metallosupramolecular Assemblies from Cu(phen)2+ (phen = 1,10‐Phenanthroline) Building Blocks and 4,4′‐Bipyridine
Authors: Seidel Rüdiger W. , Goddard Richard , Hoch Constantin , Oppel Iris M. 
Published: July 2011

AbstractAttempts to crystal engineer metallosupramolecularcomplexes from Cu(phen)2+ building blocks and the prototypical,rod‐like, exo‐bidentate ligand 4,4′‐bipyridine (4,4′‐bipy) by layering techniques are described. Reactions of Cu(phen)2+ (phen = 1,10‐phenanthroline) with 4,4′‐bipy in the presence of NO3– counterions yielded two distinct, discrete, dinuclear, Ci symmetric, dumbbell‐typecomplexes, [{Cu(NO3)2(phen)}2(4,4′‐bipy)] (1) and [{Cu(NO3)(phen)(H2O)}2(4,4′‐bipy)](NO3)2 (2), depending upon the mixture of solvents used for crystallization. In compound 1, a mono‐ and a bidentate nitrato group coordinate to Cu2+, whereas in 2 the monodentate nitrato groups are replaced by aqua ligands, which introduce additional hydrogen‐bond donor functionality to the molecule. The crystal structure of 1 was determined by single‐crystal X‐ray analysis at 296 and 110 K. Upon cooling, a disorder‐order transition occurs, with retention of the space group symmetry. The crystal structure of 2 at room temperature was reported previously [Z.‐X. Du, J.‐X. Li, Acta Cryst. 2007, E63, m2282]. We have redetermined the crystal structure of 2 at 100 K. A phase transition is not observed for 2, but the low temperature single‐crystal structure determination is of significantly higher precision than the room temperature study. Both 1 and 2 are obtained phase‐pure, as proven by powder X‐ray diffraction of the bulk materials. Crystals of [Cu(phen)(CF3SO3)2(4,4′‐bipy)·0.5H2O]n (3), a one‐dimensional coordination polymer, were obtained from [Cu(CF3SO3)2(phen)(H2O)2] and 4,4′‐bipy. In 3, Cu(phen)2+ corner units are joined by 4,4′‐bipy via the two vacant cis sites to form polymeric zig‐zag chains, which are tightly packed in the crystal. Compounds 1–3 were further studied by infrared spectroscopy.
Rituximab for childhood refractory nephrotic syndrome
Authors: Iijima Kazumoto 
Published: July 2011

AbstractSeveral therapies including immunosuppressive agents have been shown to be effective and safe for frequently relapsing nephrotic syndrome/steroid‐dependent nephrotic syndrome (FRNS/SDNS) and steroid‐resistant nephrotic syndrome in children. It is evident, however, that a substantial number of children are still refractory to treatment despite these therapies. Rituximab is a chimeric monoclonal antibody, which inhibits CD20‐mediated B‐cell proliferation and differentiation. It was first introduced for the treatment of B‐cell non‐Hodgkin's lymphoma and was subsequently administered to patients with autoimmune diseases, such as rheumatoid arthritis, lupus erythematosus, or immunocomplex glomerulonephritis. Recently, a number of case reports and non‐controlled clinical trials have suggested that rituximab may be effective for children with refractory nephrotic syndrome. Controlled prospective trials, however, are required to establish the value of rituximab in refractory nephrotic syndrome. The purpose of the present study was therefore to evaluate the efficacy and safety of rituximab in childhood‐onset refractory nephrotic syndrome. The Research Group of Childhood‐onset Refractory Nephrotic Syndrome (RCRNS) conducted a randomized, double‐blind, placebo‐controlled, multi‐center clinical trial (RCRNS‐01) and an open‐label, multi‐center, pharmacokinetic clinical trial (RCRNS‐02). These two trials were investigator‐initiated, registration‐directed clinical trials designed to apply Ministry of Health, Labour and Welfare approval for the use of rituximab for childhood‐onset refractory FRNS/SDNS in Japan. RCRNS‐01 could be the first study to clarify whether rituximab is effective and safe for childhood‐onset refractory FRNS/SDNS.
Analysis of a new two-parameter equation of state for MgO
Authors: Liu Quan 
Published: July 2011

In this paper, a new two-parameter equation of state (EOS) is developed on the basis of lattice potential theory. The expressions are also obtained for isothermal bulk modulus and its pressure derivative. Numerical analysis is presented for MgO at high pressures (up to 260 GPa) and high temperatures (up to 2000 K). Results based on the new EOS are found to compare well with the corresponding values derived from a first principles approach.
Notch1 Expression, Which Is Related to p65 Status, Is an Independent Predictor of Prognosis in Colorectal Cancer
Authors: Chu Dake , Zhou Yi , Zhang Zixi , Li Yuming , Li Jipeng , Zheng Jianyong , Zhang Hongwei , Zhao Qingchuan , Wang Weizhong , Wang Rui'an , Ji Gang 
Published: July 2011

Abstract
Purpose: Notch1 has been proven to be aberrantly expressed in colorectal cancer and related to tumor differentiation status. However, few previous studies concentrated on the predictive role of Notch1 expression on the overall survival of patients with colorectal cancer. This study explored expression of Notch1 and its relationship with p65 and prognosis in colorectal cancer.
Experimental Design: Two independent study cohorts were involved in the present study. Clinical specimens from 941 eligible patients were constructed into tissue microarrays. The expression of Notch1 and p65 protein was investigated by immunohistochemistry.
Results: Statistically significant positive correlations were found between protein expression of Notch1 and p65 in both retrospective and prospective study cohorts. Patients with higher Notch1 expression showed a trend of having shorter survival time, whereas patients with lower Notch1 expression had better survival in both study cohorts. In multivariate analysis, Notch1 expression was proven to be an independent predictor of prognosis. Moreover, the prognostic value of Notch1 might differ according to p65 status.
Conclusions: Notch1 is an independent predictor of prognosis for patients with colorectal cancer. In addition, the predictive role of Notch1 on clinical outcome might be modified by p65 status, suggesting that targeting Notch1 and nuclear factor κB (NF-κB) might be a promising strategy for colorectal cancer treatment. Clin Cancer Res; 17(17); 5686–94. ©2011 AACR.
Dual paraneoplastic syndromes in a patient with small cell lung cancer: a case report
Authors: Conners Kristin , Woods Scott E , Webb Michael 
Published: July 2011

Abstract
Introduction
We describe the case of a patient with small cell lung cancer and dual paraneoplastic syndromes involving adrenocorticotropic hormone and calcitonin. To the best of our knowledge, dual paraneoplastic syndromes involving these two hormones have not been previously reported in the literature.

Case presentation
A 74-year-old Caucasian woman presented with a left hilar mass and metastatic disease in the liver and right adrenal gland. The patient complained only of intermittent diarrhea. Her laboratory values exhibited metabolic alkalosis with hypokalemia, hypocalcemia, hypomagnesemia, hypophosphatemia, and hyperglycemia.

Conclusion
We discuss the work-up and treatment of the patient's unusual laboratory presentation with two concurrent paraneoplastic syndromes.
Changements structurels : le cas des consommations alimentaires en France de 1949 à 1988
Authors: Combris Pierre 
Published: July 2011

Strukturelle Änderungen: der Fall des Lebensmittelkonsums in Frankreich zwischen 1949 und 1988,
von Pierre Combris.

Die Analyse der Konsumentwicklung iiber einen längeren Zeitraum hinweg wirft die Frage der Änderungen des Verbraucherverhaltens auf. In diesem Artikel wird die Stabilität der disaggregierten Funktionen der Nachfrage der Haushalte zwischen 1949 und 1988 analysiert. Der Schwerpunkt liegt hierbei auf den Lebensmitteln, insbesondere auf dem Bruch mit den Gewohnheiten beim yerbrauch von Fleisch, das in Nordamerika und in Australien immer mehr Gegenstand von Diskussionen ist. Fälle von Änderungen bei den Verbraucherpräf erenzen sind, wie es scheint, unbestreitbar.