bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Steric Influence of N‐Phosphorus‐arylimines on the Rhodium‐Catalyzed Asymmetric Arylation.
Authors: Hao Xinyu , Chen Qian , Yamada Ken‐ichi , Yamamoto Yasutomo , Tomioka Kiyoshi 
Published: December 2011

AbstractThe bulkiness of the N‐phosphorus groups at imines (I) influences both the reactivity and enantioselectivity of the rhodium/chiral amidophosphane catalyzed arylation reaction with boroxine (II).
ChemInform Abstract: A New Class of Heterogeneous Pd Catalysts for Synthetic Organic Chemistry.
Authors: Pagliaro Mario , Pandarus Valerica , Beland Francis , Ciriminna Rosaria , Palmisano Giovanni , Cara Piera Demma 
Published: December 2011

Abstract4 Examples of Pd catalysts (trademarked SiliaCat Pd(0)‐hydrogels) are prepared by changing the synthetic conditions to give highly dispersed Pd nanoparticles encapsulated within an organosilica matrix (ORMOSIL).
ChemInform Abstract: Efficient Synthesis of Unsymmetric Diarylalkynes from Decarboxylative Coupling in a Continuous Flow Reaction System.
Authors: Lee Hee Joon , Park Kyungho , Bae Goun , Choe Jaehoon , Song Kwang Ho , Lee Sunwoo 
Published: December 2011

AbstractOnly trace amounts of symmetrical diarylalkynes are obtained in some cases as by‐ products.
ChemInform Abstract: Formation of Fluorene and Anthracene Derivatives in Reactions of Perfluorinated 1‐Alkyl‐1‐phenyl‐ and 1‐Alkyl‐2‐phenyl‐1,2‐dihydrocyclobutabenzenes with Antimony Pentafluoride.
Authors: Mezhenkova T. V. , Karpov V. M. , Platonov V. E. 
Published: December 2011

AbstractThe reaction of the compounds (I) and (II) under different temperatures gives different major products and also various other derivatives as by‐products.
ChemInform Abstract: Synthesis of Stereodefined Fused δ‐Hydroxy‐γ‐lactones from Dealkylative Cyclization of Epoxy‐Diesters.
Authors: Pehlivan Leyla , Jacolot Maiwenn , Coia Nicolas , Monteiro Nuno , Bouyssi Didier , Balme Genevieve 
Published: December 2011

AbstractTreatment of aryl‐substituted substrates with Tms‐I or Tos‐OH produces the required lactones via dealkylative cyclization.
ChemInform Abstract: Tandem Cyclization—Michael Reaction by Combination of Metal‐ and Organocatalysis.
Authors: Aleman Jose , del Solar Virginia , Martin‐Santos Cecilia , Cubo Leticia , Ranninger Carmen Navarro 
Published: December 2011

AbstractIn the presence of PtCl2(dmso)2 and DABCO alkynyl malonates undergo tandem cyclization—Michael addition which allows facile access to lactones of type (III) and (V) bearing a quaternary center at C‐3.
ChemInform Abstract: Three‐Component Synthesis of Polysubstituted Pyrroles from α‐Diazoketones, Nitroalkenes, and Amines.
Authors: Hong Deng , Zhu Yuanxun , Li Yao , Lin Xufeng , Lu Ping , Wang Yanguang 
Published: December 2011

AbstractIf diazoacetate is used instead of the ketones (I) no products can be isolated.
ChemInform Abstract: A Flexible Approach to Protected (4S,5S)‐5‐Alkyl‐1‐benzyl‐4‐benzyloxy‐2‐pyrrolidinones.
Authors: Xiao Zhen‐Hua , Liu Liang‐Xian , Liu Cong , Huang Pei‐Qiang 
Published: December 2011

AbstractA new reductive dehydroxylation of trans‐ enriched, diastereoisomeric α‐hydroxylactames (I) gives cis‐pyrrolidones (II) with modest to good diastereoselectivity.
ChemInform Abstract: A Facile Pathway to Enantiomerically Enriched 3‐Hydroxy‐2‐oxindoles: Asymmetric Intramolecular Arylation of α‐Keto Amides Catalyzed by a Palladium—DifluorPhos Complex.
Authors: Yin Liang , Kanai Motomu , Shibasaki Masakatsu 
Published: December 2011

AbstractThe method is applicable to aryl triflates bearing different aromatic and aliphatic substituents, as well as sterically hindered β‐keto amide (XII).
ChemInform Abstract: An Efficient Difluorohydroxylation of Indoles Using Selectfluor as a Fluorinating Reagent.
Authors: Lin Riyuan , Ding Shengtao , Shi Zhuangzhi , Jiao Ning 
Published: December 2011

AbstractIt provides a mild, convenient and regioselective approach to 3,3‐difluoroindolin‐2‐ols.
ChemInform Abstract: Tandem Reactions of 1,2,4‐Oxadiazoles with Allylamines.
Authors: Palumbo Piccionello Antonio , Pace Andrea , Buscemi Silvestre 
Published: December 2011

AbstractTwo novel thermal rearrangements are presented: the addition of allylamine (II) to oxadiazoles proceeds via ring‐opening followed by cycloaddition.
ChemInform Abstract: Synthesis of New Perfluoroalkylated 1,3,4‐Oxadiazoles and 1,2,4‐Triazoles Starting from 2‐(Perfluoroalkyl)ethane Thiols.
Authors: Akremi Ali , Beji Mohamed , Baklouti Ahmed 
Published: December 2011

AbstractAll products are purified by recrystallization.
ChemInform Abstract: AlCl3 as an Effective Lewis Acid for the Synthesis of Arylaminotetrazoles.
Authors: Habibi Davood , Nasrollahzadeh Mahmoud , Bayat Yadollah 
Published: December 2011

AbstractAlCl3‐catalyzed reaction of aryl cyanamides with NaN3 affords regioselectively 1‐acyl‐5‐aminotetrazoles (II) or 5‐arylaminotetrazoles (IV) depending on the electrophilicity of the aryl substituents in the cyanamides.
ChemInform Abstract: Enantioselective Diels—Alder Reactions of Enals and Alkylidene Diketones Catalyzed by N‐Heterocyclic Carbenes.
Authors: Fang Xinqiang , Chen Xingkuan , Chi Yonggui Robin 
Published: December 2011

AbstractSubstrates with electron‐withdrawing groups other than ‐CO‐Ar at the α‐position of the chalcone are tested (‐CO‐O‐Et, ‐CN, ‐Ph) but fail to react.
ChemInform Abstract: Synthesis of Multifunctionalized Chromeno[2,3‐c]pyrrol‐9(2H)‐ones: Investigation and Application of Baker—Venkataraman Rearrangement Involved Reactions Catalyzed by 4‐(Dimethylamino)pyridine.
Authors: Yu Yanjun , Hu Yun , Shao Weiyan , Huang Jianing , Zuo Yinglin , Huo Yingpeng , An Linkun , Du Jun , Bu Xianzhang 
Published: December 2011

AbstractA novel efficient synthesis of title chromenopyrrolones is presented.
ChemInform Abstract: Synthesis and Insecticidal Evaluation of Novel N‐Pyridylpyrazolecarboxamides Containing Different Substituents in the ortho‐Position.
Authors: Feng Qi , Yu Guanping , Xiong Lixia , Wang Mingzhong , Li Zhengming 
Published: December 2011

AbstractAll new N‐pyridylpyrazolecarboxamides (III), (V), (VII), (IX), (XI) and (XIII) show moderate insecticidal activities against oriental armywhorm (Mythimna separata).
ChemInform Abstract: An Unusual Iodocyclization: An Efficient Synthesis of Pyrimidine‐Anellated Spiro‐heterocycles.
Authors: Majumdar K. C. , Ray Krishanu , Ganai Sintu 
Published: December 2011

AbstractA simple and efficient method for the synthesis of the title compounds (II) is presented via iodocyclization in the absence of any base.
ChemInform Abstract: Direct Synthesis of Chiral 1,2,3,4‐Tetrahydropyrrolo[1,2‐a]pyrazines via a Catalytic Asymmetric Intramolecular Aza‐Friedel—Crafts Reaction.
Authors: He Yuwei , Lin Maohui , Li Zhongmin , Liang Xinting , Li Guilong , Antilla Jon C. 
Published: December 2011

AbstractA new, efficient, and enantioselective method to prepare a number of title pyrrolopyrazines is reported.
ChemInform Abstract: Three‐Component Condensation of 4‐Aryl‐1,4‐dihydrobenzo[4,5]imidazo[1,2‐a][1,3,5]triazin‐2‐amines with Formaldehyde and Primary Amines.
Authors: Potapov A. Yu. , Shestakov A. S. , Verezhnikov V. N. , Shikhaliev Kh. S. 
Published: December 2011

AbstractThe title reaction of triazine (V) proceeds with elimination of pyridinecarbaldehyde.
ChemInform Abstract: Facile Synthesis of 4H‐1,2,4‐Benzothiadiazine‐1,1‐dioxides.
Authors: Cherepakha Artem , Kovtunenko Vladimir O. , Tolmachev Andrey , Lukin Oleg , Nazarenko Konstantin G. 
Published: December 2011

AbstractNo column chromatography is necessary to purify the respective product.
ChemInform Abstract: Direct Conversion of Pinacol Arylboronic Esters to Aryl Triolborates.
Authors: Li Gao‐Qiang , Kiyomura Shunsuke , Yamamoto Yasunori , Miyaura Norio 
Published: December 2011

AbstractA simple and practical method which is compatible with various functional groups for the synthesis of the stable compounds (III) and (V) is described.
ChemInform Abstract: Reaction of N,N‐Disubstituted Perfluoroalkanethioamides with Trialkyl Phosphites. A New Method for the Synthesis of Polyfluorinated α‐Aminophosphonates.
Authors: Mykhaylychenko Sergiy S. , Pikun Nadiia V. , Shermolovich Yuriy G. 
Published: December 2011

AbstractThe reaction of thioamides (I) and (V) with trialkyl phosphites affords vinyl phosphonates, probably via intermediates of type (IV).
ChemInform Abstract: Convenient Synthesis of Fluoroalkyl α‐ and β‐Aminophosphonates.
Authors: Roeschenthaler Gerd‐Volker , Kukhar Valery P. , Kulik Irene B. , Sorochinsky Alexander E. , Soloshonok Vadim A. 
Published: December 2011

AbstractThe addition of alkyl phosphites (II) or the α‐carbanion of phosphonate (V) to aldimines (I) provides access to fluoroalkyl aminophosphonates (IV) and (VII), respectively.
ChemInform Abstract: Silica Gel‐Immobilized Aluminum Phthalocyanine Complex as a Heterogeneous Catalyst for the Synthesis of α‐Amino Phosphonates.
Authors: Matveeva E. D. , Shuvalov M. V. , Zefirov N. S. 
Published: December 2011

AbstractAluminum phthalocyanine complexes immobilized onto silica gel exhibit high catalytic activity and stability in the Kabachnik—Fields reaction.
ChemInform Abstract: Regio‐ and Stereoselective Synthesis of 2‐Deoxy‐C‐aryl Glycosides via Palladium—Catalyzed Decarboxylative Reactions.
Authors: Xiang Shaohua , Cai Shuting , Zeng Jing , Liu Xue‐Wei 
Published: December 2011

AbstractThe reaction of benzoic acids substituted with strong electron‐donating groups at the 2,4‐ or 2,6‐ position succeeds with high yields in a short times.
ChemInform Abstract: A Fully Palladium‐Mediated Construction of Phenanthrenes and Naphthoxindoles.
Authors: Nassar‐Hardy Luma , Deraedt Christophe , Fouquet Eric , Felpin Francois‐Xavier 
Published: December 2011

AbstractA three‐step synthesis of naphthoxindole alkaloids (V) is presented, involving a Pd‐catalyzed direct intramolecular C—H arylation as key step.
ChemInform Abstract: Pseuduvarines A and B, Two New Cytotoxic Dioxoaporphine Alkaloids from Pseuduvaria rugosa.
Authors: Taha Hairin , Hadi A. Hamid A. , Nordin Noraziah , Najmuldeen Ibrahim A. , Mohamad Khalit , Shirota Osamu , Nugroho Alfarius E. , Piow Wong Chin , Kaneda Toshio , Morita Hiroshi 
Published: December 2011

AbstractPseuduvarines A (Ia) and B (Ib) show cytotoxicity against the human cancer cell lines MCF7, HepG2, and HL‐60.
ChemInform Abstract: Synthesis and anti‐HIV Evaluation of 3′‐Triazolo Nucleosides.
Authors: Roy Vincent , Obikhod Aleksandr , Zhang Hong‐Wang , Coats Steven J. , Herman Brian D. , Sluis‐Cremer Nicolas , Agrofoglio Luigi A. , Schinazi Raymond F. 
Published: December 2011

AbstractA series of title compounds of type (I) and (II) are tested for their anti‐HIV activities.
ChemInform Abstract: Design, Synthesis and Antibacterial Activity of Novel Ketolides Bearing an Aryltetrazolyl‐Substituted Alkyl Side Chain.
Authors: Song Qiu‐Ling , Guo Bao‐Qin , Zhang Wen , Lan Ping , Sun Ping‐Hua , Chen Wei‐Min 
Published: December 2011

AbstractA series of novel C‐11,12 cyclic carbamate ketolides (17 examples) are synthesized from clarithromycin and evaluated for their antibacterial activities.
ChemInform Abstract: Biosynthetic Capacities of Actinomycetes. Part 59. Elaiomycins B (I) and C (II), Novel Alkylhydrazides Produced by Streptomyces sp. BK190
Authors: Kim Byung‐Yong , Willbold Stefanie , Kulik Andreas , Helaly Soleiman E. , Zinecker Heidi , Wiese Jutta , Imhoff Johannes F. , Goodfellow Michael , Suessmuth Roderich D. , Fiedler Hans‐Peter 
Published: December 2011

Abstractphysico‐chemical properties and cytotoxicity
ChemInform Abstract: Atom‐Economic and Stereoselective Syntheses of the Ring A and B Subunits of the Bryostatins.
Authors: Trost Barry M. , Yang Hanbiao , Brindle Cheyenne S. , Dong Guangbin 
Published: December 2011

AbstractDiverse methods are presented to obtain stereo‐ and chemoselectively the title subunits.
ChemInform Abstract: The Natural Product CCR5 Antagonist Anibamine and Its Analogues as Antiprostate Cancer Agents.
Authors: Haney Kendra M. , Zhang Feng , Arnatt Christopher K. , Yuan Yunyun , Li Guo , Ware Joy L. , Gewirtz David A. , Zhang Yan 
Published: December 2011

AbstractBased on the novel structural skeleton of anibamine, a series of analogues is designed and synthesized.
ChemInform Abstract: Synthesis and Insecticidal Activities of Novel 1,3,4‐Thiadiazole 5‐Fluorouracil Acetamides Derivatives: An RNA Interference Insecticide.
Authors: Wan Rong , Zhang Jian‐Qiang , Han Fen , Wang Peng , Yu Peng , He Qiu 
Published: December 2011

Abstract18 Title compounds of type (I) are evaluated for their insecticidal activities.
ChemInform Abstract: Development of a Highly Selective Fluorescence Probe for Alkaline Phosphatase.
Authors: Kawaguchi Mitsuyasu , Hanaoka Kenjiro , Komatsu Toru , Terai Takuya , Nagano Tetsuo 
Published: December 2011

AbstractTokyoGreen‐methyleneoxy phosphate (I)(TG‐mPhos) is the first fluorescence probe that shows selectivity for alkaline phosphatase (ALP) over protein tyrosine phosphatase and protein serine/threonine phosphatase.
ChemInform Abstract: Retention of Palladium and Phosphine Ligands Using Nanoporous Polydicyclopentadiene Thimbles
Authors: Gupta Abhinaba , Long Tyler R. , Rethwisch David G. , Bowden Ned B. 
Published: December 2011

AbstractThimbles composed of polydicyclopentadiene retain Pd catalyst and phosphine ligands used in Buchwald—Hartwig and Sonogashira coupling reactions but allow the products to permeate.
ChemInform Abstract: Five‐Membered Heterocycles: 1,2‐Azoles. Part 2. Isoxazoles and Isothiazoles
Authors: Silva Artur M. S. , Tome Augusto C. , Pinho e Melo Teresa M. V. D. , Elguero Jose 
Published: December 2011

AbstractReview: 416 refs.
Correlation of biomechanics to tissue reaction in aortic aneurysms assessed by finite elements and [18F]–fluorodeoxyglucose–PET/CT
Authors: Maier Andreas , Essler Markus , Gee Michael W. , Eckstein Hans‐Henning , Wall Wolfgang A. , Reeps Christian 
Published: December 2011

SUMMARYMechanobiological interactions are essential for the adaption of the cardiovascular system to altered environmental and internal conditions, but are poorly understood with regard to abdominal aortic aneurysm (AAA) pathogenesis, growth and rupture. In the present study, we therefore calculated mechanical AAA quantities using nonlinear finite element methods and correlated these to [18F]‐fluorodeoxyglucose (FDG)‐metabolic activity in the AAA wall detected by positron emission tomography/computed tomography (PET/CT). The interplay between mechanics and FDG‐metabolic activity was analyzed in terms of maximum values and the three‐dimensional spatial relationship, respectively.Fluorodeoxyglucose‐positron emission tomography/computed tomography (FDG‐PET/CT) data sets of n = 18 AAA patients were studied. Maximum FDG‐uptake (SUV max) in the AAA wall varied from 1.32 to 4.60 (average SUV max 3.31 ±0.87). Maximum wall stresses and strains ranged from 10.0 to 64.0 N∕cm2 (38.2 ±13.8  N∕cm2) and from 0.190 to 0.260 (0.222 ±0.023), respectively. SUV max was significantly correlated to maximum wall stress and strain (SUV max to stress: r = 0.71,p = 0.0005; SUV max to strain: r = 0.66,p = 0.0013). To evaluate the three‐dimensional spatial interaction between FDG‐uptake and acting wall stress, element‐wise correlations were performed. In all but 2 AAAs, positive element‐wise correlation of FDG‐uptake to wall stress was obtained, with the Pearson's correlation coefficient ranging from −0.168 to 0.738 ( 0.372 ±0.263).The results indicate that mechanical stresses are correlated quantitatively and spatially to FDG‐uptake in the AAA wall. It is hypothesized that unphysiologically increased loading in the AAA wall triggers biological tissue reaction, such as inflammation or regenerative processes, causing elevated FDG‐metabolic activity. These findings strongly support experimental hypotheses of mechanotransduction mechanisms in vivo. Copyright © 2011 John Wiley & Sons, Ltd.
Heterogeneous Fenton Catalysts Based on Activated Carbon and Related Materials
Authors: Navalon Sergio , Dhakshinamoorthy Amarajothi , Alvaro Mercedes , Garcia Hermenegildo 
Published: December 2011

AbstractThe Fenton reaction is widely used for remediation of waste water and for the degradation of organic pollutants in water. Currently, there is considerable interest to convert the classical Fenton reaction, which consumes stoichiometric amounts of iron(II) salts, into a catalytic process that is promoted by a solid. This review describes the work that has used carbonaceous materials either directly as catalysts or, more frequently, as a large‐area support for catalytically activated transition metals or metal‐oxide nanoparticles. The interest in this type of catalyst derives from the wide use of carbon in conventional water treatments and the wide applicability of the Fenton reaction. After two general sections that illustrate the scope and background of Fenton chemistry, the review describes the activity of activated carbon in the absence or presence of metal‐containing particles. The last sections of the review focus on different types of carbonaceous materials, such as carbon nanotubes and diamond nanoparticles. The review concludes with a section that anticipates future developments in this area, which are aimed at overcoming the current limitations of low activity and occurrence of metal leaching.
CO Oxidation at the Perimeters of an FeO/Pt(111) Interface and how Water Promotes the Activity: A First‐Principles Study
Authors: Gu Xiang‐Kui , Ouyang Runhai , Sun Dapeng , Su Hai‐Yan , Li Wei‐Xue 
Published: December 2011

AbstractThe catalytic role of the PtFe cation ensemble presented at the perimeters of the FeO film supported on Pt(111) for low‐temperature CO oxidation and the promotion of water on activity were studied by using DFT calculations. We found that the perimeter sites along the edge of the FeO islands on Pt provided a favorable ensemble that consisted of coordinatively unsaturated ferrous species and nearby Pt atoms for O2 and H2O activation free from CO poison. A dissociative oxygen atom at the PtFe cation ensemble reacts easily with CO adsorbed on nearby Pt. The OH group from water dissociation not only facilitates activation of the oxygen molecule, more importantly it opens a facile reaction channel for CO oxidation through the formation of the carboxyl intermediate. The presence of the OH group on the FeO film strengthens interfacial interactions between FeO and Pt(111), which would make the FeO film more resistant to further oxidation. The importance of the PtFe cation ensemble and the role of water as a cocatalyst for low‐temperature CO oxidation is highlighted.
Cationic Group 4 Metallocene–(o‐Phosphanylaryl)oxido Complexes: Synthetic Routes to Transition‐Metal Frustrated Lewis Pairs
Authors: Chapman Andy M. , Haddow Mairi F. , Wass Duncan F. 
Published: December 2011

AbstractSynthetic routes to cationic group 4 metallocene–(o‐phosphanylaryl)oxido compounds of the type [CpR2M(OPR2)][WCA] (M = Ti, Zr, Hf; WCA = weakly coordinating anion) are described. The neutral mono‐methyl complexes [CpR2ZrMe(OPR2)] 1–6 [CpR = Cp (1–3) or Cp* (4); OPR2 = o‐OC6H4(PtBu)2 (1 and 4), OCMe2CH2(PtBu)2 (2) or OC(CF3)2CH2(PtBu)2 (3)] are prepared by protonolysis of [CpR2ZrMe2] by the parent alcohol. The remaining methyl group in such complexes is best removed by protonolysis with [DTBP][B(C6F5)4] (DTBP = 2,6‐di‐tert‐butylpyridinium) to yield the desired cationic complexes 7 and 8 in the case of 1 and 4. In the case of 2 and 3, this method leads to side reactions. Treatment with B(C6F5)3 yields the desired cations in all cases; however, side reactions with the generated [MeB(C6F5)3] anion in subsequent reactions leads to problems. Hafnium analogues may be synthesised by similar routes. In the case of titanium, a different method must be adopted: chloride abstraction using [Et3Si][B(C6F5)4] from the parent complex [Cp2TiCl(OPR2)]. Such cationic group 4 metallocene–(o‐phosphanylaryl)oxido compounds exhibit reactivity that is best described by the frustrated Lewis pair concept.
Asymmetric Methods for the Synthesis of Flavanones, Chromanones, and Azaflavanones
Authors: Nibbs Antoinette E. , Scheidt Karl A. 
Published: December 2011

AbstractFlavanones, chromanones, and related structures are privileged natural products that display a wide variety of biological activities. Although flavanoids are abundant in nature, there are a limited number of available general and efficient synthetic methods for accessing molecules of this class in a stereoselective manner. Their structurally simple architectures belie the difficulties involved in installation and maintenance of the stereogenic configuration at the C2 position, which can be sensitive and can undergo epimerization under mildly acidic, basic, and thermal reaction conditions. This review presents the methods currently used to access these related structures. The synthetic methods include manipulation of the flavone/flavanone core, carbon‐carbon bond formation, and carbon–heteroatom bond formation.
Phagocytosis of neuronal debris by microglia is associated with neuronal damage in multiple sclerosis
Authors: Huizinga Ruth , van der Star Baukje J. , Kipp Markus , Jong Rosa , Gerritsen Wouter , Clarner Tim , Puentes Fabiola , Dijkstra Christine D. , van der Valk Paul , Amor Sandra 
Published: December 2011

AbstractNeuroaxonal degeneration is a pathological hallmark of multiple sclerosis (MS) contributing to irreversible neurological disability. Pathological mechanisms leading to axonal damage include autoimmunity to neuronal antigens. In actively demyelinating lesions, myelin is phagocytosed by microglia and blood‐borne macrophages, whereas the fate of degenerating or damaged axons is unclear. Phagocytosis is essential for clearing neuronal debris to allow repair and regeneration. However, phagocytosis may lead to antigen presentation and autoimmunity, as has been described for neuroaxonal antigens. Despite this notion, it is unknown whether phagocytosis of neuronal antigens occurs in MS. Here, we show using novel, well‐characterized antibodies to axonal antigens, that axonal damage is associated with HLA‐DR expressing microglia/macrophages engulfing axonal bulbs, indicative of axonal damage. Neuronal proteins were frequently observed inside HLA‐DR+ cells in areas of axonal damage. In vitro, phagocytosis of neurofilament light (NF‐L), present in white and gray matter, was observed in human microglia. The number of NF‐L or myelin basic protein (MBP) positive cells was quantified using the mouse macrophage cell line J774.2. Intracellular colocalization of NF‐L with the lysosomal membrane protein LAMP1 was observed using confocal microscopy confirming that NF‐L is taken up and degraded by the cell. In vivo, NF‐L and MBP was observed in cerebrospinal fluid cells from patients with MS, suggesting neuronal debris is drained by this route after axonal damage. In summary, neuroaxonal debris is engulfed, phagocytosed, and degraded by HLA‐DR+ cells. Although uptake is essential for clearing neuronal debris, phagocytic cells could also play a role in augmenting autoimmunity to neuronal antigens. © 2011 Wiley Periodicals, Inc.