bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pilot study of early integration of interventional pain management for patients with chronic cancer pain.
Authors: Van Wieren Inga , Gorra Madeline , Jamison Robert , Enzinger Andrea Catherine 
Published: June 2024

e24080 Background: Pain is a common, distressing, and costly complication of cancer. Treatment guidelines recommend consideration of interventional pain procedures in addition to pharmacotherapy, yet they are underutilized and often only considered for refractory pain despite high-dose opioids. We examined the feasibility of early integration of interventional pain management among ambulatory patients with chronic cancer pain. Methods: This single arm pilot feasibility study recruited patients from outpatient clinics at the Dana-Farber Cancer Institute. Eligible patients had metastatic or locally advanced solid tumors, persistent pain secondary to cancer/cancer treatment, average pain rating of 4 or higher (0-10 scale), and prognosis > 6 months. Patients could not be taking more than 200 oral morphine equivalents per day. Patients were systematically referred to an interventional pain specialist for consideration of pain procedures, with monthly visits for 4 months. Measures of feasibility included the proportion of patients seen by the pain specialist within 4 weeks, and the proportion undergoing pain procedures. Patients completed surveys at baseline, 2 and 4 months; using the Consumer Assessment of Healthcare Providers and Systems (CAHPS), patients rated their satisfaction with pain clinic (range 0-10), and how often the pain doctor treated them with courtesy and respect, listened carefully, and explained things in a way they could understand (range 1-4, higher scores better). Among those undergoing procedures, patients indicated the percent pain relief they had from the procedure. Results: Between May 2022 and October 2023, 30 patients were enrolled (4 remain on study); mean age, 59.5, 50% male, with a variety of solid tumors; baseline “average pain” and “worst pain” scores were 4.3( SD,1.2) and 6.5( SD,1.6). All but one patient (96.7%) was seen in the pain clinic within four weeks; 57% (n = 17) received one or more pain procedure, with 20% (n = 6) undergoing repeat procedures. The most common procedures were neural blockade (8), celiac plexus neurolysis (n = 4), trigger point injection (n = 3), and epidural steroid injection (n = 3). Among patients receiving a procedure, the median percentage relief was 65% (IQR:30,80). Patients rated the quality of care from the pain clinic highly, with a mean score of 8.6( SD,1.6); and were satisfied with their pain physicians with a mean rating of 3.8( SD,0.4) on treating with respect, 3.7( SD,0.6) for listening, and 3.6( SD,0.6) for explaining. Conclusions: In this study of patients with cancer pain, systematic referral to interventional pain management specialists was feasible, and led to most patients receiving a pain procedure. Patients were satisfied with their pain care and reported meaningful relief of symptoms. Further study is needed to examine whether early integration of interventional pain management improves pain control. Clinical trial information: NCT05366413 .
Association of childhood trauma with choice of bilateral mastectomy for the treatment of unilateral breast cancer.
Authors: Jagielo Annemarie D. , Benedict Catherine , Zewde Nahom , Neri Eric , Nouriani Bita , Spiegel David 
Published: June 2024

e24096 Background: Patients are increasingly choosing bilateral mastectomy (BMX) for the treatment of primary breast cancer (BC) despite minimal survival benefits and potential for adverse medical and psychosocial consequences. Exposure to childhood trauma is associated with dysregulation of stress response systems, threat perception alterations, increased risk-taking behaviors, and body dissatisfaction. We examined childhood trauma in relation to treatment decision-making in adulthood within a sample of breast cancer patients undergoing either BMX or more conservative BC treatment. Methods: Secondary analyses of a case-control study of the neurobiological and affective determinants of BMX choice were conducted. Cross-sectional data from the baseline survey were analyzed. Participants were recruited via institutional clinic practices, social media, and patient advocacy groups. Patients completed a medical status questionnaire and the Childhood Trauma Questionnaire (CTQ). Chi-square and Mann-Whitney U tests examined differences in treatment decision-making by childhood trauma exposure and type. Results: The sample included 137 patients with unilateral stages 0-III BC (mean age 49.2; SD = 11.2; 76.6% White; 10.9% Hispanic/Latina; 68.6% married). Seven tested positive for a BRCA gene mutation. Patients were divided between BMX (n = 66) and non-BMX (n = 71) treatment groups. On average, patients in the non-BMX group reported higher levels of childhood trauma severity (Median = 7; IQR = 0-12.5) compared to patients in the BMX group (Median = 4; IQR = 0-11.75; Mann Whitney U = 4728; small effect size; SRD = -0.11; p = .26). Patients who reported a major parental upheaval (e.g., divorce, separation) were significantly more likely to pursue non-BMX compared to BMX (small effect size; SRD = -.16; p = .047). Patients who reported any uncategorized major upheaval were more likely to choose non-BMX than BMX (small effect size; SRD = -.14), but group differences did not reach significance (p = .093) . No other statistically significant relationships were observed. Conclusions: Contrary to hypotheses, preliminary results suggest BC patients who were exposed to traumatic events in childhood may be more likely to elect conservative BC surgical treatments. Trauma-related hypervigilance to threats may cause patients to exercise more caution regarding treatment choice. More research exploring the effects of adverse childhood experiences in the BC population is warranted. [Table: see text]
ACE-BREAST-03: A phase 2 trial evaluating ARX788, an anti-HER2 antibody drug conjugate (ADC), for the treatment of HER2+ metastatic breast cancer (mBC) in patients who have been previously treated with trastuzumab deruxtecan (T-DXd).
Authors: Tripathy Debashish , Ali Kashif , Agrawal Laila , Ali Sami M. , Blau Sibel , Block Margaret , Danso Michael A. , Yardley Denise , Andersen Jay , Waks Adrienne Gropper , Jayachandran Priya , Makhlin Igor , Nikolinakos Petros , Zuniga Richard , O'Shaughnessy Joyce , Aung Sandra , Lu Janice M. , Kalinsky Kevin , Gradishar William John , Rugo Hope S. 
Published: June 2024

TPS1123 Background: HER2-targeted ADCs revolutionized treatment for patients with HER2+ mBC. The HER2-targeted ADC, T-DXd, improved PFS and OS vs T-DM1 (trastuzumab emtansine) as second-line treatment for HER2+ mBC and is now the preferred treatment option in this setting. However, new treatment options are needed for patients with disease progression on T-DXd. Novel technological advances in design of the antibody, linker, and payload of ADCs may further improve the safety/tolerability and efficacy, widening the therapeutic window to address resistance to other anti-HER2 therapies. ARX788 is a next-generation anti-HER2 ADC stably conjugated to AS269 (a potent tubulin inhibitor). Proprietary site-specific oxime conjugation chemistry, enabled by incorporation of synthetic amino acids into the antibody construct, maximizes the delivery of the cytotoxic payload to tumor cells and minimizes systemic exposure of free payload. ARX788 has shown antitumor activity in heavily pretreated patients with HER2+ and HER2-low mBC, including those with prior T-DXd exposure. Methods: ACE-Breast-03 (NCT04829604) is a Phase 2 trial evaluating ARX788 in patients previously treated with T-DXd. The primary efficacy endpoint is response rate by RECIST v1.1. Approximately 40 patients will be enrolled. Eligible patients have HER2+ mBC and up to 5 prior treatment regimens for mBC, including T-DXd. Patients must have central laboratory-confirmed HER2+ mBC; new pre-treatment biopsies may be required. Patients with treated and stable brain metastases who are off steroids are eligible. Treatment includes 1.5 mg/kg Q3W ARX788 for up to 26 cycles or until disease progression. Tumor status is assessed every 9 weeks through 27 weeks and every 12 weeks thereafter. The study is currently enrolling in the US. Clinical trial information: NCT04829604 .
Eating disorders in pediatric population, analysis of some of the most common risk factors
Authors: Czeczotka Magdalena , Skorupska Marta , Popławska Natalia Aleksandra , Śliz Justyna , Woźniak Krzysztof 
Published: June 2024

Introduction:
This article reviews a number of studies that have sought to determine what are risk factors that may cause eating disorders in the pediatric population, taking into account the age and gender of the subjects. This study focuses on issues related to purging, bulimic behaviors, and psychological orthorexia and what impact the most common risk factors for these behaviors have in the pediatric population.

Aim of study:
The aim of the study is to present a comprehensive review of some of the most common risk factors predisposing to the development of eating disorders in the pediatric population, and how these factors have a direct impact on each other and are intertwined, by using available knowledge, paying particular attention to a new potential risk factor - social media.

Materials and methods:
Materials used in this study were found in the PubMed database, using the following keywords: ,,Social media”, ,,Mass media”, ,,Peers”, ,,Family”, ,,Orthorexia nervosa”, ,,Social media”, ,,Children”, ,,Adolescence”.

Conclusion:
Eating disorders are a growing problem. Our research focuses on potential risk factors, with the greatest emphasis on a relatively new risk factor: social media and screen time, and how these two factors influence young minds, what impact they have on the eating habits of children and adolescents, and what can be done to prevent eating disorders in the pediatric population.
Funções Executivas, Traços de Psicopatia e Comportamento Sexual em Adolescentes Privados de Liberdade em Rondônia
Authors: Corrêa Pedro Vasconcelos , De Almeida Rosa Maria Martins 
Published: June 2024

Foram avaliadas as funções executivas, traços de psicopatia, idades da primeira relação sexual e trabalho de adolescentes em conflito com a lei. As hipóteses foram que haveria diferenças entre primários e reiterantes e o papel preditor destas variáveis para o ato. O objetivo geral foi avaliar essas funções, comparar intragrupo, identificar associações e predições para a infração. Foram avaliados 109 adolescentes institucionalizados por atos graves, sendo a média de idade de 16,5 anos. Instrumentos utilizados: Wisconsin de Classificação de Cartas, a Escala Hare Psychopathy Checklist-Revised e protocolo neuropsicológico. A análise de variância diferenciou os grupos em oito variáveis, sendo que nos reiterantes houve maiores traços de psicopatia e idade da primeira infração. A idade da primeira relação sexual não diferenciou os grupos, caracterizando-os como precoce exposição. E, as funções executivas explicaram 12,1% no desfecho infração. Houve associações com a história de vida em contexto de adversidades, indicando que as funções executivas em desenvolvimento podem não protegê-los de influências negativas adversas. Realidade que acentua o papel do desenvolvimento neurobiológico nas avaliações, acompanhamentos e intervenções em situação de institucionalização de privação de liberdade socioeducativa de adolescentes por atos com grave uso de violência.
Examining speech-language pathology research relating to people with traumatic brain injury in China: a scoping review
Authors: Wei Guanyu , Riccardi Jessica Salley 
Published: June 2024

Background/Aims Although there are many researchers reviewing the existing evidence related to traumatic brain injury from speech-language pathologists' perspectives, there have been no attempts to review the existing research evidence in Standard Chinese to the best of the authors' knowledge. The purpose of this scoping review was to identify and synthesise the existing research evidence available in China for therapy related to individuals with traumatic brain injury within the speech-language pathologists' scope of practice. Methods This scoping review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews. The literature search was conducted using databases that included articles in the Standard Chinese language. In collaboration with three therapists working in China, the data was extracted and translated into English. Results Eight research articles met the inclusion and exclusion criteria of this review. Six studies were randomised control trials, and two studies were cohort studies. These eight studies focused on collaboration, counselling and treatment. All studies addressed cognition and two also addressed language. Conclusions Evidence showed that treatment focusing on cognitive and language skills provided by speech-language pathologists can improve the lives of people with a traumatic brain injury living in China. More research is warranted to better understand traumatic brain injury and treatment efficacy in China. Implications for practice Clinicians, especially those who work with individuals who affiliate themselves with the Chinese culture, can consider the current research evidence discussed in this article when working with clients with traumatic brain injury. Additionally, for researchers, future research efforts can prioritise addressing the identified gaps outlined in this study.
Outpatient insulin use in type 2 diabetes mellitus and acute respiratory distress syndrome outcomes: A retrospective cohort study
Authors: Khattar Georges , Asmar Samer , Aoun Laurence , Saliba Fares , Almardini Shaza , Abu Baker Saif , Hong Catherine , El Chamieh Carolla , Haddadin Fadi , Habib Toni , Mourad Omar , Morcos Zeina , Arafa Fatema , Mina Jonathan , El Gharib Khalil , Aldalahmeh Mohammad , Khan Salman , Bou Sanayeh Elie 
Published: June 2024

BACKGROUND
The impact of type 2 diabetes mellitus (T2DM) on acute respiratory distress syndrome (ARDS) is debatable. T2DM was suspected to reduce the risk and complications of ARDS. However, during coronavirus disease 2019 (COVID-19), T2DM predisposed patients to ARDS, especially those who were on insulin at home.
AIM
To evaluate the impact of outpatient insulin use in T2DM patients on non-COVID-19 ARDS outcomes.
METHODS
We conducted a retrospective cohort analysis using the Nationwide Inpatient Sample database. Adult patients diagnosed with ARDS were stratified into insulin-dependent diabetes mellitus (DM) (IDDM) and non-insulin-dependent DM (NIDDM) groups. After applying exclusion criteria and matching over 20 variables, we compared cohorts for mortality, duration of mechanical ventilation, incidence of acute kidney injury (AKI), length of stay (LOS), hospitalization costs, and other clinical outcomes.
RESULTS
Following 1:1 propensity score matching, the analysis included 274 patients in each group. Notably, no statistically significant differences emerged between the IDDM and NIDDM groups in terms of mortality rates (32.8% vs 31.0%, P = 0.520), median hospital LOS (10 d, P = 0.537), requirement for mechanical ventilation, incidence rates of sepsis, pneumonia or AKI, median total hospitalization costs, or patient disposition upon discharge.
CONCLUSION
Compared to alternative anti-diabetic medications, outpatient insulin treatment does not appear to exert an independent influence on in-hospital morbidity or mortality in diabetic patients with non-COVID-19 ARDS.
Dosimetric risk factors for radiation esophagitis in patients with breast cancer following regional nodal radiation
Authors: Ji Mei-Chen , Li Zhi-Jia , Li Ke , Wang Yun-Xiao , Yang Bo , Lv Lin-Lin , Su Ying , Zhang Zhi-Wei , Huo Zhong-Chao , Qi Qing , Lu Yong-Chang , Cui Zhi-Qiang , Liu Yan-Bao 
Published: June 2024

BACKGROUND
Radiation esophagitis (RE) is one of the most common clinical symptoms of regi-onal lymph node radiotherapy for breast cancer. However, there are fewer studies focusing on RE caused by hypofractionated radiotherapy (HFRT).
AIM
To analyze the clinical and dosimetric factors that contribute to the development of RE in patients with breast cancer treated with HFRT of regional lymph nodes.
METHODS
Between January and December 2022, we retrospectively analysed 64 patients with breast cancer who met our inclusion criteria underwent regional nodal intensity-modulated radiotherapy at a radiotherapy dose of 43.5 Gy/15F.
RESULTS
Of the 64 patients in this study, 24 (37.5%) did not develop RE, 29 (45.3%) developed grade 1 RE (G1RE), 11 (17.2%) developed grade 2 RE (G2RE), and none developed grade 3 RE or higher. Our univariable logistic regression analysis found G2RE to be significantly correlated with the maximum dose, mean dose, relative volume 20-40, and absolute volume (AV) 20-40. Our stepwise linear regression analyses found AV30 and AV35 to be significantly associated with G2RE (P < 0.001). The optimal threshold for AV30 was 2.39 mL [area under the curve (AUC): 0.996; sensitivity: 90.9%; specificity: 91.1%]. The optimal threshold for AV35 was 0.71 mL (AUC: 0.932; sensitivity: 90.9%; specificity: 83.9%).
CONCLUSION
AV30 and AV35 were significantly associated with G2RE. The thresholds for AV30 and AV35 should be limited to 2.39 mL and 0.71 mL, respectively.
Effect of Luhong formula on the cardiac rehabilitation of patients with chronic heart failure
Authors: Xu Ji-Jie , Dai Jian , Xie Qi-Hai , Du Pei-Chao , Li Cha , Zhou Hua 
Published: June 2024

BACKGROUND
Current treatments for chronic heart failure (CHF) are therapeutically ineffective. The optimization of treatments for this disease needs to be explored and analyzed.
AIM
To analyze the effect of using Luhong Formula in the cardiac rehabilitation of patients with CHF and its influence on cardiopulmonary function (CPF) and prognosis.
METHODS
In total, 160 patients with CHF admitted between June 2022 and June 2023 were selected, including 75 receiving perindopril (control group) and 85 receiving Luhong Formula (research group). We conducted comparative analyses on the curative effects of traditional Chinese medicine (TCM) syndromes and cardiac function, CPF [oxygen consumption at the anaerobic threshold (VO2 AT) and at peak exercise (peak VO2)], echocardiographic indexes [left atrial volume index (LAVI), left ventricular muscle mass index (LVMI), left ventricular ejection fraction (LVEF)], and prognosis [major adverse cardiovascular events (MACEs) at 6 months follow-up].
RESULTS
The research group showed markedly higher curative effects of TCM syndromes and cardiac function than the control group. In addition, post-treatment VO2 AT, peak VO2, LVMI and LVEF in the research group were significantly higher, whereas LAVI was significantly lower, than those of the control group. Furthermore, fewer patients in the research group developed MACEs at the 6-month follow-up.
CONCLUSION
Luhong Formula is more therapeutically effective than perindopril for the cardiac rehabilitation of patients with CHF, specifically in enhancing CPF and prognosis.
Diagnostic efficacy of virtual organ computer-assisted analysis in measuring the volume ratio of subchorionic hematoma with serum progesterone
Authors: Shen Lin-Ling , Shi Jing , Ding Chang-Wei , Dai Gao-Le , Ma Qi 
Published: June 2024

BACKGROUND
Subchorionic hematoma (SCH) is a common complication in early pregnancy characterized by the accumulation of blood between the uterine wall and the chorionic membrane. SCH can lead to adverse pregnancy outcomes such as miscarriage, preterm birth, and other complications. Early detection and accurate assessment of SCH are crucial for appropriate management and improved pregnancy outcomes.
AIM
To evaluate the diagnostic efficacy of virtual organ computer-assisted analysis (VOCAL) in measuring the volume ratio of SCH to gestational sac (GS) combined with serum progesterone on early pregnancy outcomes in patients with SCH.
METHODS
A total of 153 patients with SCH in their first-trimester pregnancies between 6 and 11 wk were enrolled. All patients were followed up until a gestational age of 20 wk. The parameters of transvaginal two-dimensional ultrasound, including the circumference of SCH (Cs), surface area of SCH (Ss), circumference of GS (Cg), and surface area of GS (Sg), and the parameters of VOCAL with transvaginal three-dimensional ultrasound, including the three-dimensional volume of SCH (3DVs) and GS (3DVg), were recorded. The size of the SCH and its ratio to the GS size (Cs/Cg, Ss/Sg, 3DVs/3DVg) were recorded and compared.
RESULTS
Compared with those in the normal pregnancy group, the adverse pregnancy group had higher Cs/Cg, Ss/Sg, and 3DVs/3DVg ratios (P < 0.05). When 3DVs/3DVg was 0.220, the highest predictive performance predicted adverse pregnancy outcomes, resulting in an AUC of 0.767, and the sensitivity, specificity were 70.2%, 75% respectively. VOCAL measuring 3DVs/3DVg combined with serum progesterone gave a diagnostic AUC of 0.824 for early pregnancy outcome in SCH patients, with a high sensitivity of 82.1% and a specificity of 72.1%, which showed a significant difference between AUC.
CONCLUSION
VOCAL-measured 3DVs/3DVg effectively quantifies the severity of SCH, while combined serum progesterone better predicts adverse pregnancy outcomes.
Effects of psychological nursing in Parkinson's related depression patients undergoing functional magnetic resonance imaging: A randomized controlled trial
Authors: Zhang Xiao-Xia , Zhang Xiao-Hui , Dong Yan-Chao 
Published: June 2024

BACKGROUND
Patients with Parkinson’s disease (PD) often experience depression, and some may require magnetic resonance imaging (MRI) for diagnosis, which can lead to MRI failure due to claustrophobia.
AIM
To explore the value of psychological interventions in successfully completing functional MRI scans of the brain for PD-related depression.
METHODS
Ninety-six patients with PD were randomly divided into two groups. The control group (47 patients) received general care, and the experimental group (49 patients) received general care combined with psychological care. The Unified Parkinson's Disease Assessment Scale (UPDRS), Hamilton Depression Scale (HAMD), and Geriatric Depression Scale (GDS)-15 scores, heart rate, systolic blood pressure, and MRI-Anxiety Questionnaire (MRI-AQ) scores before and after the scan were recorded. The completion rate of magnetic resonance (MR) scanning, scanning duration, and image quality scores were recorded.
RESULTS
Before scanning, no statistically significant difference was observed between the two groups in terms of heart rate, systolic blood pressure, and UPDRS, HAMD, GDS-15, and MRI-AQ scores. After scanning, systolic blood pressure, MRI-AQ score, and scan time in the experimental group were significantly lower than those in the control group, whereas the scan completion rate and image quality score were significantly higher than those in the control group.
CONCLUSION
Psychological nursing interventions are helpful in alleviating PD-related depression and assessing MR depression scores and may be helpful in the successful completion of functional MRI scans of the patient's brain.