bluuebunny/crossref_metadata_2025_split huggingface dataset:
Propensity vectors of low‐ASA residue pairs in the distinction of protein interactions
Authors: Liu Qian , Li Jinyan 
Published: August 2009

AbstractWe introduce low‐ASA residue pairs as classification features for distinguishing the different types of protein interactions. A low‐ASA residue pair is defined as two contact residues each from one chain that have a small solvent accessible surface area (ASA). This notion of residue pairs is novel as it first combines residue pairs with the O‐ring theory, an influential proposition stating that the binding hot spots at the interface are often surrounded by a ring of energetically less important residues. As binding hot spots lie in the core of the stability for protein interactions, we believe that low‐ASA residue pairs can sharpen the distinction of protein interactions. The main part of our feature vector is 210‐dimensional, consisting of all possible low‐ASA residue pairs; the value of every feature is determined by a propensity measure. Our classification method is called OringPV, which uses propensity vectors of protein interactions for support vector machine. OringPV is tested on three benchmark datasets for a variety of classification tasks such as the distinction between crystal packing and biological interactions, the distinction between two different types of biological interactions, etc. The evaluation frameworks include within‐dataset, cross‐dataset comparison, and leave‐one‐out cross‐validation. The results show that low‐ASA residue pairs and the propensity vector description of protein interactions are truly strong in the distinction. In particular, many cross‐dataset generalization capability tests have achieved excellent recalls and overall accuracies, much outperforming existing benchmark methods. Proteins 2010. © 2009 Wiley‐Liss, Inc.
Guidance on developing safety performance indicators
Authors: Jennings Kim , Schulberg Francine 
Published: August 2009

AbstractThis article summarizes a process for developing safety performance indicators. This is a topic of great importance for the measurement of the effectiveness of our PSM systems. The PSM is the OSHA regulation that covers companies in the United States that was issued in the year 1992. Since that time companies in the process industries have made great strides in implementing PSM systems. An important question is “How much progress have we made in actually reducing the number and severity of process events?” Other countries were also concerned about the effectiveness of their programs to address chemical accidents. In response to these concerns, the OECD published the documents described in this article.One of these documents sets out a safety performance indicator process that allows a company to:
assess whether it is implementing appropriate chemical safety programs and policies,
evaluate whether these programs and policies are achieving their desired objectives, and
help determine the extent to which such programs and policies are making a difference.
This will allow a company to identify whether there is appropriate emphasis on different aspects of safety management and provide insights needed for setting priorities for future investment of resources. © 2009 American Institute of Chemical Engineers Process Saf Prog 2009
Improved integration of LOPA with HAZOP analyses
Authors: Baum Dick , Faulk Nancy , Pérez P.E. John 
Published: August 2009

AbstractIntegrating Layer of Protection Analysis (LOPA) with Hazard and Operability Analysis (HAZOP) has many advantages over performing these studies separately. The merits include: fewer actions from the combined effort compared to performing only a HAZOP; team continuity resulting from the combined effort as opposed to two separate teams having possibly differing points of view; and, ultimately, a time and cost savings realized by the combination. This integration defines the risk associated with a given scenario, enabling better decisions that impact business assurance.By using the Center for Chemical Process Safety guidelines to define the independent protection layers upfront, the gray areas can often be reduced or eliminated; thereby enabling a more thorough LOPA. Examples include taking credit if a unit has two independent operators (outside and inside) responding to critical alarms, or taking credit for centralized control rooms that may allow immediate operator interaction and response.This article shows how the guidelines have been used successfully in joint HAZOP/LOPA studies, and describes an initial preparation protocol that can ensure high‐quality results. © 2009 American Institute of Chemical Engineers Process Saf Prog, 2009
LOPA as practiced at a global manufacturing API facility
Authors: Evenson G. , Befus S. , Dolfi M. , Muir A. , Pinho D. 
Published: August 2009

AbstractThe standard risk assessment practices used in industry since the OSHA 1910.119 regulation was issued, are to conduct Process Hazard Analyses (PHAs) for hazardous and exothermic (or otherwise high risk) processes. During PHAs, the potential consequences of an undesired event are evaluated along with the safeguards that exist to mitigate the consequences or reduce the frequency of the event. If the PHA team determines that the risk is still not tolerable, additional safeguards are recommended to reach a tolerable level of risk. Typically, a Quantitative Risk Assessment can be completed to evaluate the effectiveness of these existing or newly proposed safeguards. Unfortunately, this is a complex and time‐consuming task. The relatively new methodology of Layer of Protection Analysis (LOPA) allows a PHA team to evaluate the effectiveness of safeguards in reducing risk in an efficient yet semiquantitative fashion using some basic assumptions and standard lookup tables. The LOPA methodology can be utilized to evaluate the effectiveness of Safety Instrumented Functions (SIF) (e.g., automated critical interlocks and alarms) to achieve a tolerable risk. The LOPA methodology provides consistency in an approach to risk assessments and communications. It can support an effective mechanical integrity or risk‐based maintenance system for critical components of an SIF. This article describes LOPA and includes several scenarios that will provide an overview of how the LOPA methodology is used in a multibatch pharmaceutical facility. © 2009 American Institute of Chemical Engineers Process Saf Prog, 2009
Wave propagation through elastic granular and granular auxetic materials
Authors: Koenders M. A. ‘Curt’ 
Published: August 2009

AbstractThe wave propagation through a material with a granular micro‐structure is investigated. The simplest such medium is the granular medium of equal spheres. The theory demonstrates that for long wavelengths the micro‐structured material exhibits modes of wave motion that are also found for a traditional medium (that is, a medium that satisfies simple continuum stress equilibrium laws and no consideration for particle spin and moment of inertia of the particles is accounted for). However, an extra shear wave and rotational oscillatory particle motion are also found. The limit of a traditional material is obtained by letting tangential contact stiffnesses vanish. Towards higher wave numbers the micro‐structure reveals itself in the shear wave speeds by displaying strongly anomalous behaviour compared to a traditional isotropic, elastic medium. An expansion in terms of structural sums (these are sums over the contact interaction weighed with a string of branch vectors) is explored. The lowest order non‐trivial terms (second order structural sums) yield basic behaviour, but a higher order expansion (including fourth order sums) shows a more pronounced anomaly for wave numbers approaching the inverse particle diameter. Yet higher order terms capture more information than can possibly be present in a granular medium and it is senseless to examine these. The theory is relevant to granular materials and granular auxetics. In the latter case the tangential contact stiffness needs to exceed the normal stiffness, which is not possible for ordinary solid contacts, but can be achieved with special arrangements.
Effect of periodicity of the two‐dimensional vacancy planes on the thermal conductivity of bulk Ga2Te3
Authors: Kim Chang‐eun , Kurosaki Ken , Ishimaru Manabu , Jung Do‐young , Muta Hiroaki , Yamanaka Shinsuke 
Published: August 2009

AbstractGa2Te3 contains structural vacancies due to the valence mismatch between the cation and anion, and these vacancies make regularly arranged two‐dimensional (2D) planes with approximately 3.5‐nanometer intervals. Most likely due to the effective phonon scattering by the vacancy planes, Ga2Te3 exhibits an unexpectedly low thermal conductivity (κ). In the present study, the effect of the periodicity of the 2D vacancy planes on the κ of Ga2Te3 was investigated. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Quercetin improves cognitive deficits in rats with chronic cerebral ischemia and inhibits voltage‐dependent sodium channels in hippocampal CA1 pyramidal neurons
Authors: Yao Y. , Han D. D. , Zhang T. , Yang Z. 
Published: August 2009

AbstractQuercetin is a flavonoid compound found in a number of medicinal plants that are often prescribed in Chinese clinics for the treatment of cardiovascular diseases. The present study investigated the effects of quercetin on chronic cerebral ischemia in rats produced through bilateral occlusion of the carotid arteries. Treatment of quercetin (5 mg/kg i.p. for 14 days) was found to improve the performance of learning and memory of ischemic rats in the Morris water maze. Additionally, in electrophysiological experiments, quercetin attenuated the inhibition of long‐term potentiation (LTP) in ischemic rats. Also, in acutely isolated rat hippocampal CA1 pyramidal neurons, quercetin (0.3, 3 and 30 µm) decreased the amplitude of voltage‐dependent sodium currents in a dose‐ and voltage‐dependent manner. Taken together, these data lend further support for the neuroprotective effects of quercetin and suggest that a therapeutic effect on cerebral ischemia and vascular dementia of quercetin could be due to its inhibition of sodium channels. Copyright © 2009 John Wiley & Sons, Ltd.
On integrating Kano's model dynamics into QFD for multiple product design
Authors: Raharjo Hendry , Brombacher Aarnout C. , Goh T. N. , Bergman Bo 
Published: August 2009

AbstractThe design for Six Sigma (DFSS) framework places a strong emphasis on the need to conform to the customer needs or voices early in the design phase. The key problem, in the context of a rapidly changing environment due to influx of new technology and innovation, is that things may become obsolete much faster than ever. What now delights the customer will become an expected need in the near future. Such dynamics is, unfortunately, very often overlooked and has not been adequately addressed in the literature. To fill in this niche, this paper proposes a methodology to advance the use of the quality function deployment (QFD), as one of the widely accepted tools in products or services design process, with respect to Kano's model dynamics. Specifically, based on the information from Kano questionnaire, it provides a quantitative approach to observe and follow the change over time. Not only can it show how fast a certain Kano's category changes over time, but it can also forecast the future needs, which is useful to tackle the customer preference's change during product creation process. Afterwards, the forecasted customer needs can be used within an optimization framework for multiple product design. An illustrative example is provided to give some practical insights. Copyright © 2009 John Wiley & Sons, Ltd.
Nonhydrodynamic collective processes in molten salts: Theory and ab initio simulations
Authors: Bryk Taras , Mryglod Ihor 
Published: August 2009

AbstractWe review recent progress in theory and ab initio simulations of collective dynamics in molten salts. Main focus is made on the dispersion of nonhydrodynamic optic‐like excitations. A concept of “bare” propagating modes is used for the analysis of polarization effects on the dispersion of longitudinal optic modes. Ab initio molecular dynamics in combination with the generalized modes approach is used for consistent calculations of collective excitations spectra in molten NaI, LiF, and RbF. © 2009 Wiley Periodicals, Inc. Int J Quantum Chem, 2010
Theoretical infrared line shapes of H‐bonds within the strong anharmonic coupling theory and Fermi resonances effects
Authors: Issaoui Noureddine , Rekik Najeh , Oujia Brahim , Wójcik Marek J. 
Published: August 2009

AbstractIn this article, we extend a previous work toward presenting a theoretical study of the effects of Fermi resonances and the fundamental anharmonic coupling parameter α between the high‐frequency mode and the H‐bond bridge. The model incorporates (i) both intrinsic anharmonicities of the fast mode (double well potential) and the H‐bond Bridge (Morse potential), (ii) strong anharmonic coupling theory, (iii) Fermi resonances by the aid of an anharmonic coupling between the fast mode and one or several harmonic bending modes, (iv) quadratic modulation of both the angular frequency and the equilibrium position of the X$\vec H$…Y stretching mode on the intermonomer $\vec X$H…$\vec Y$ motions, and (v) the quantum direct (fast and bending modes) and indirect dampings (slow mode). The IR spectral density is obtained by Fourier transform of the autocorrelation function of the transition dipole moment operator of the XH bond. The numerical calculation shows that Fermi resonances generate very complicated profiles with multisubstructure and also provide a direct evidence of Fermi resonances which were predicted to be a major feature of H‐bonds. © 2009 Wiley Periodicals, Inc. Int J Quantum Chem, 2010
Performance analysis of reset control systems
Authors: Aangenent W. H. T. M. , Witvoet G. , Heemels W. P. M. H. , van de Molengraft M. J. G. , Steinbuch M. 
Published: August 2009

AbstractIn this paper we present a general linear matrix inequality‐based analysis method to determine the performance of a SISO reset control system in both the ℒ︁2gain and ℋ︁2sense. In particular, we derive convex optimization problems in terms of LMIs to compute an upperbound on the ℒ︁2gain performance and the ℋ︁2norm, using dissipativity theory with piecewise quadratic Lyapunov functions. The results are applicable to for all LTI plants and linear‐based reset controllers, thereby generalizing the available results in the literature. Furthermore, we provide simple though convincing examples to illustrate the accuracy of our proposed ℒ︁2gain and ℋ︁2norm calculations and show that, for an input constrained ℋ︁2problem, reset control can outperform a linear controller designed by a common nonlinear optimization method. Copyright © 2009 John Wiley & Sons, Ltd.
Producers and the fair trade distribution systems: what are the benefits and problems?
Authors: Bezençon Valéry 
Published: August 2009

AbstractFair Trade presents several benefits to the participating producers and cooperatives, such as higher prices or advance payment. However, the shift from an alternative system of distribution to a mainstreaming strategy focusing on sales and using the conventional distribution structures could have altered certain producer benefits. This case study first aims to investigate an alternative partnership between a Swiss foundation and a Cameroonian cooperative producing and processing fruits, in order to analyse the benefits and problems of such a system from a producer perspective. Then, based on the content analysis of published case studies on cooperatives whose products are sold through mainstream distribution, the second objective is to discuss and compare the types of benefit and problem of Fair Trade according to the system in which producers operate. The article concludes with the complementarities between the two systems. Copyright © 2009 John Wiley & Sons, Ltd and ERP Environment.
Determination of the relative sputtering yield of carbon to tantalum by means of Auger electron spectroscopy depth profiling
Authors: Kotis L. , Menyhard M. , Sulyok A. , Sáfrán G. , Zalar A. , Kovač J. , Panjan P. 
Published: August 2009

AbstractThe relative sputtering yield of carbon with respect to tantalum was determined for 1 keV Ar+ ion bombardment in the angular range of 70°–82° (measured from surface normal) by means of Auger electron spectroscopy depth profiling of C/Ta and Ta/C bilayers. The ion bombardment‐induced interface broadening was strongly different for the C/Ta and Ta/C, whereas the C/Ta interface was found to be rather sharp, the Ta/C interface was unusually broad. Still the relative sputtering yields (YC/YTa) derived from the Auger electron spectroscopy depth profiles of the two specimens agreed well. The relative sputtering yields obtained were different from those determined earlier on thick layers, calculated by simulation of SRIM2006 and by the fitting equation of Eckstein. The difference increases with increase of angle of incidence. Copyright © 2009 John Wiley & Sons, Ltd.
In Vivo Physiological Transdifferentiation of Adult Adipose Cells
Authors: De Matteis Rita , Zingaretti Marcia Cristina , Murano Incoronata , Vitali Alessandra , Frontini Andrea , Giannulis Ioanis , Barbatelli Giorgio , Marcucci Francesco , Bordicchia Marica , Sarzani Riccardo , Raviola Elio , Cinti Saverio 
Published: August 2009

Abstract
Grafts of adipose tissue from adult Rosa26 mice from different sites of the body, irrespective of the sex of the donor, share with the mammary fat the property of giving rise to milk-secreting epithelial cells when exposed to the microenvironment of the mammary gland in pregnant and lactating females. To rule out the possibility that the labeled mammary glandular tissue was derived from stem cells associated with the stroma vascular part of the grafts, we injected into the mammary gland a pure suspension of adipocytes obtained by treating a fragment of adipose tissue with collagenase. X-gal–positive cells were inserted into the alveoli of the native gland, and electron microscopy showed that the labeled cells had transformed into milk-secreting glandular cells. At the site of the adipocyte injection, the labeled alveoli contained a mixture of X-gal–positive and X-gal–negative cells, and a single epithelial cell was occasionally stained in an otherwise unlabeled alveolus. This suggests that growing ducts individually recruit adjacent adipocytes that transdifferentiate into secretory epithelial cells as they became part of the glandular alveoli. After dissociation, the isolated adipocytes retained the morphology and protein markers typical of differentiated fat cells but expressed high levels of stem cell genes and the reprogramming transcription factor Klf4. Thus, the well-documented osteogenic, chondrogenic, myogenic, and angiogenic transformation of preadipocytes associated with the stroma vascular component of the adipose tissue may reflect an intrinsic capability of adipocytes to reprogram their gene expression and transform into different cytotypes.
Disclosure of potential conflicts of interest is found at the end of this article.
Negotiating with the Chinese: EANTs and all
Authors: Rivers Cheryl 
Published: August 2009

AbstractThe Chinese negotiation style remains enigmatic for many foreign negotiators. This article is written for foreign negotiators going to China and explores how Chinese negotiators think about ethically ambiguous negotiation tactics (EANTs), focusing on how the relationship with the other party influences the appropriateness of such tactics. Two studies are presented: an interpretation of interview data followed by a survey that shows Chinese negotiators rate EANTs as significantly less appropriate when they have a relationship with the other party. Advice for negotiators going to China is provided. © 2009 Wiley Periodicals, Inc.
The garage team—entrepreneurship lessons from DHL international
Authors: Chung Po 
Published: August 2009

AbstractWhen you start a venture, you start with yourself: your own personal operating system, or POS. Then, you identify and define your compelling product or service, something you should already know a lot about. You also need to use your sales skills to convince key stakeholders to support you, and to design your venture by putting together a pattern that works. The next step is to put together a team to help you implement the pattern you have designed, the men and women who will make up your garage team. The garage team is made up of the core people in a start‐up, people who help graduate the entrepreneur to the role of leader, because a leader with no followers is a leader of none. This article explores the essential attributes of such a team and how they contribute to the success of entrepreneurial ventures. © 2009 Wiley Periodicals, Inc.
Microarray studies on the genes responsive to the addition of spermidine or spermine to a Saccharomyces cerevisiae spermidine synthase mutant
Authors: Chattopadhyay Manas K. , Chen Weiping , Poy George , Cam Margaret , Stiles David , Tabor Herbert 
Published: August 2009

AbstractThe naturally occurring polyamines putrescine, spermidine or spermine are ubiquitous in all cells. Although polyamines have prominent regulatory roles in cell division and growth, precise molecular and cellular functions are not well‐established in vivo. In this work we have performed microarray experiments with a spermidine synthase, spermine oxidase mutant (Δspe3 Δfms1) strain to investigate the responsiveness of yeast genes to supplementation with spermidine or spermine. Expression analysis identified genes responsive to the addition of either excess spermidine (10−5 M) or spermine (10−5 M) compared to a control culture containing 10−8 M spermidine. 247 genes were upregulated > two‐fold and 11 genes were upregulated >10‐fold after spermidine addition. Functional categorization of the genes showed induction of transport‐related genes and genes involved in methionine, arginine, lysine, NAD and biotin biosynthesis. 268 genes were downregulated more than two‐fold, and six genes were downregulated > eight‐fold after spermidine addition. A majority of the downregulated genes are involved in nucleic acid metabolism and various stress responses. In contrast, only a few genes (18) were significantly responsive to spermine. Thus, results from global gene expression profiling demonstrate a more major role for spermidine in modulating gene expression in yeast than spermine. Copyright © 2009 John Wiley & Sons, Ltd.