bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolved histone tail regulates 53BP1 recruitment at damaged chromatin
Authors: Kelliher Jessica L. , Folkerts Melissa L. , Shen Kaiyuan V. , Song Wan , Tengler Kyle , Stiefel Clara M. , Lee Seong-Ok , Dray Eloise , Zhao Weixing , Koss Brian , Pannunzio Nicholas R. , Leung Justin W. 
Published: May 2024

AbstractThe master DNA damage repair histone protein, H2AX, is essential for orchestrating the recruitment of downstream mediator and effector proteins at damaged chromatin. The phosphorylation of H2AX at S139, γH2AX, is well-studied for its DNA repair function. However, the extended C-terminal tail is not characterized. Here, we define the minimal motif on H2AX for the canonical function in activating the MDC1-RNF8-RNF168 phosphorylation-ubiquitination pathway that is important for recruiting repair proteins, such as 53BP1 and BRCA1. Interestingly, H2AX recruits 53BP1 independently from the MDC1-RNF8-RNF168 pathway through its evolved C-terminal linker region with S139 phosphorylation. Mechanistically, 53BP1 recruitment to damaged chromatin is mediated by the interaction between the H2AX C-terminal tail and the 53BP1 Oligomerization-Tudor domains. Moreover, γH2AX-linker mediated 53BP1 recruitment leads to camptothecin resistance in H2AX knockout cells. Overall, our study uncovers an evolved mechanism within the H2AX C-terminal tail for regulating DNA repair proteins at damaged chromatin.
Determinants of incomplete penta vaccination among children aged 12 to 23 months in South-West Ethiopia
Authors: Kefeni Bilisumamulifna Tefera , Chibsa Samuel Ejeta , Roba Debele Gebiso 
Published: May 2024

AbstractGlobally dropout rate for the three dose of penta (DPT) vaccine was highest in the African region. This mainly occurred in the African Region including Ethiopia. Despite high national incomplete vaccination status, there is lack of study on the determinants of incomplete vaccination in south west region, Ethiopia. Therefore, this study was conducted to identify determinants of incomplete Penta vaccination among children aged 12 to 23 months in Mettu district South-West Ethiopia. A Community based case–control study was conducted from April 24, May 23, 2022 in South-west Ethiopia. Data was collected from 297 participants (99 cases and 198controls) by using simple random sampling techniques. Cases were children age from 9 to 23 months who missed at least one dose from the routine vaccine and controls were completed the entire routine vaccine schedule. Data was entered to Epi-data version 3.1 and exported to SPSS version 23 for statistical analyses. Binary and multivariable logistic regression with a 95% CI and a p-value of < 0.05 was done to declare statistical significance. A total of 95 cases and 197 controls participated in the study. Rural residence [AOR: 3.9; 95% CI; (1.6, 9.4)], wealth indexes [AOR: 3.6; 95% CI; (1.8,7.0)], mothers unimmunized tetanus toxoid [AOR: 4.3; 95% CI; (2.1, 8.6)], postponed schedule [AOR: 4.6; 95% CI; (2.4, 8.8)], un satisfied to service [AOR: 3.7; 95% CI; (1.7,7.6)] and poor perception on benefit of vaccine [AOR:2.7; 95% CI; (1.2, 6.1)] were determinants of incomplete vaccination. Rural Residence, Family wealth index of poor; Mother not received tetanus vaccination; postponed vaccination schedule client satisfaction and caretaker perception on benefit of vaccination were identified determinants of incomplete vaccination.Health information should be given for the community and child caretaker on the benefit of complete vaccination. Community should be encouraged to not post pond vaccine schedule. Pregnant women should be strengthening to receive tetanus toxoid vaccine during pregnancy.
Establishment of a risk prediction model for olfactory disorders in patients with transnasal pituitary tumors by machine learning
Authors: Chen Min , Li Yuxin , Zhou Sumei , Zou Linbo , Yu Lei , Deng Tianfang , Rong Xian , Shao Shirong , Wu Jijun 
Published: May 2024

AbstractTo construct a prediction model of olfactory dysfunction after transnasal sellar pituitary tumor resection based on machine learning algorithms. A cross-sectional study was conducted. From January to December 2022, 158 patients underwent transnasal sellar pituitary tumor resection in three tertiary hospitals in Sichuan Province were selected as the research objects. The olfactory status was evaluated one week after surgery. They were randomly divided into a training set and a test set according to the ratio of 8:2. The training set was used to construct the prediction model, and the test set was used to evaluate the effect of the model. Based on different machine learning algorithms, BP neural network, logistic regression, decision tree, support vector machine, random forest, LightGBM, XGBoost, and AdaBoost were established to construct olfactory dysfunction risk prediction models. The accuracy, precision, recall, F1 score, and area under the ROC curve (AUC) were used to evaluate the model's prediction performance, the optimal prediction model algorithm was selected, and the model was verified in the test set of patients. Of the 158 patients, 116 (73.42%) had postoperative olfactory dysfunction. After missing value processing and feature screening, an essential order of influencing factors of olfactory dysfunction was obtained. Among them, the duration of operation, gender, type of pituitary tumor, pituitary tumor apoplexy, nasal adhesion, age, cerebrospinal fluid leakage, blood scar formation, and smoking history became the risk factors of olfactory dysfunction, which were the key indicators of the construction of the model. Among them, the random forest model had the highest AUC of 0.846, and the accuracy, precision, recall, and F1 score were 0.750, 0.870, 0.947, and 0.833, respectively. Compared with the BP neural network, logistic regression, decision tree, support vector machine, LightGBM, XGBoost, and AdaBoost, the random forest model has more advantages in predicting olfactory dysfunction in patients after transnasal sellar pituitary tumor resection, which is helpful for early identification and intervention of high-risk clinical population, and has good clinical application prospects.
A comprehensive performance analysis of advanced hybrid MPPT controllers for fuel cell systems
Authors: Touti Ezzeddine , Rafikiran Shaik , Graba Besma Bechir , Aoudia Mouloud , Senthilkumar S. 
Published: May 2024

AbstractThe present power generation corporations are working on Renewable Power Systems (RPS) for supplying electrical power to the automotive power industries. There are several categories of RPSs available in the atmosphere. Among all of the RPSs, the most general power network used for Electric Vehicles (EVs) is hydrogen fuel which is available in nature. The H2 fuel is fed to the Proton Exchange Membrane Fuel Stack (PEMFS) for producing electricity for the EV stations. The advantages of this selected fuel system are more power conversion efficiency, environmentally friendly, low carbon emissions, more power density, less starting time, plus able to work at very low-temperature values. However, this fuel stack faces the issue of a nonlinear power density curve. Due to this nonlinear power supply from the fuel stack, the functioning point of the overall network changes from one position of the I–V curve to another position. So, the peak voltage extraction from the fuel stack is not possible. In this article, there are various metaheuristic optimization-based Maximum Power Point Tracking (MPPT) methodologies are studied along with the conventional methods for obtaining the Maximum Power Point (MPP) position of the PEMFS. From the simulative investigation, the Continuous Different Slope Value-based Cuckoo Search Method (CDSV with CSM) provides better efficiency with more output power. Also, for all the MPPT methods comprehensive analysis has been made by utilizing the simulation results.
Objectivity interrogation of racial scholarship in psychology and management
Authors: Torrez Brittany , Dupree Cydney H. , Kraus Michael W. 
Published: May 2024

AbstractScholars of color remain underrepresented in US institutions in academia. In this paper, we will examine one factor that contributes to their continued marginalization in psychology and management: the scientific method’s commitment to traditional notions of objectivity. We argue that objectivity—defined as practices and policies rooted in the heightened value placed on a research process that is ostensibly free from bias—is central to the prominence of primarily White scholarship in psychology and management research and remains central to knowledge production. To investigate this, we employ a mixed-methods approach, integrating qualitative and quantitative data to codify how scholars of color experience objectivity interrogations, or written and verbal questioning in academic contexts that implicates their scientific rigor. We also identify how scholars of color engage in objectivity armoring, or self-presentational strategies (toning down and stepping up) to contend with these interrogations. Finally, we reveal these toning down processes in language use within publications on racial scholarship. Overall, these studies reveal the unique challenges scholars of color face to legitimize and validate their work on race and racism within predominantly White institutions and disciplines.
MRI-based vertebral bone quality score as a novel bone status marker of patients with adolescent idiopathic scoliosis
Authors: Yang Dan-dan , Li Yi , Tian Jiang-yu , Li Ya , Liu Jian , Liu Yun-song , Cao Xin-wen , Liu Chuan 
Published: May 2024

AbstractTo investigate the application of MRI-based vertebral bone quality (VBQ) score in assessing bone mineral density (BMD) for patients with adolescent idiopathic scoliosis (AIS). We reviewed the data of AIS patients between January 2021 and October 2023 with MRI, whole-spine plain radiographs, quantitative computed tomography (QCT) and general information. VBQ score was calculated using T1-weighted MRI. Univariate analysis was applied to present the differences between variables of patients with normal BMD group (QCT Z-score > − 2.0) and low BMD group (QCT Z-score ≤ − 2.0). The correlation between VBQ score and QCT Z-score was analyzed with Pearson correlation test. A multivariate logistic regression model was used to determine the independent factors related to low BMD. Receiver operating characteristic curve (ROC) was drawn to analyze the diagnostic performance of VBQ score in distinguishing low BMD. A total of 136 AIS patients (mean age was 14.84 ± 2.10 years) were included, of which 41 had low BMD. The low BMD group had a significantly higher VBQ score than that in normal group (3.48 ± 0.85 vs. 2.62 ± 0.62, P < 0.001). The VBQ score was significantly negative correlated with QCT Z score (r =  − 0.454, P < 0.001). On multivariate analysis, VBQ score was independently associated with low BMD (OR: 4.134, 95% CI 2.136–8.000, P < 0.001). The area under the ROC curve indicated that the diagnostic accuracy of the VBQ score for predicting low BMD was 81%. A sensitivity of 65.9% with a specificity of 88.4% could be achieved for distinguishing low BMD by setting the VBQ score cutoff as 3.18. The novel VBQ score was a promising tool in distinguishing low BMD in patients with AIS and could be useful as opportunistic assessment for screening and complementary evaluation to QCT before surgery.
Current Practices Among Speech-Language Pathologists for Mild Traumatic Brain Injury: A Mixed-Methods Modified Delphi Approach
Authors: Hardin Kathryn Y. , Black Christine , Caldbick Kristine , Kelly Megan , Malhotra Alisha , Tidd Courtney , Vallentin Tina , Turkstra Lyn S. 
Published: May 2024

Purpose
The study purpose was to capture the clinical practice patterns of speech-language pathologists (SLPs) treating mild traumatic brain injury (mTBI; concussion). Study aims were to (a) characterize expert SLP practice patterns for the management of mTBI and (b) use qualitative content analysis to explore areas of quantitative variability within participants’ responses.

Method
Using a modified Delphi approach, SLPs completed an online survey, with Round 1 responses shaping questions for Round 2. Round 2 results were analyzed using a concurrent partially mixed-methods approach with quantitative and qualitative items. Quantitative consensus agreement levels were set prestudy at 75% agreement or higher. Topic-level items that did not reach consensus were analyzed using qualitative content analysis.

Participants
SLPs engaging in a specialty mTBI-SLP networking group were invited to participate. Round 1 had nine participants (United States: 4, Canada: 5). Round 2 had 18 participants (United States: 12, Canada: 6), with a mean of 15.7 years of experience in mTBI (range: 3–33) and a mean of 7.6 clients with mTBI seen weekly (range: 1–25).

Results
Nearly all topic-level practice items met quantitative consensus (42/45). Consensus areas included using conceptual frameworks, interprofessional teaming, assessment and intervention practices, goal setting, and outcomes. Functional, collaborative, and client-centered care anchored clinical practice. Areas lacking consensus included SLP roles in mTBI mental and somatic health symptoms, specific measurement tools, and intervention dosages. Qualitative themes that emerged included limited interprofessional awareness for the role of SLPs in mTBI and challenges in measurement selection.

Conclusions
Study aims were met with clear consensus on clinical patterns implemented by SLPs specializing in mTBI. Results will inform both current clinical practices and future practice guidelines. High-level guidance and advocacy are needed to clarify SLP practice concerns and advance interprofessional education. Future work should address identified gaps, including targeted assessment tools and consensus on intervention methods.
Prosodic and Visual Cues Facilitate Irony Comprehension by Mandarin-Speaking Children With Cochlear Implants
Authors: Yu Qianxi , Li Honglan , Li Shanpeng , Tang Ping 
Published: May 2024

Purpose:
This study investigated irony comprehension by Mandarin-speaking children with cochlear implants, focusing on how prosodic and visual cues contribute to their comprehension, and whether second-order Theory of Mind is required for using these cues.

Method:
We tested 52 Mandarin-speaking children with cochlear implants (aged 3–7 years) and 52 age- and gender-matched children with normal hearing. All children completed a Theory of Mind test and a story comprehension test. Ironic stories were presented in three conditions, each providing different cues: (a) context-only, (b) context and prosody, and (c) context, prosody, and visual cues. Comparisons were conducted on the accuracy of story understanding across the three conditions to examine the role of prosodic and visual cues.

Results:
The results showed that, compared to the context-only condition, the additional prosodic and visual cues both improved the accuracy of irony comprehension for children with cochlear implants, similar to their normal-hearing peers. Furthermore, such improvements were observed for all children, regardless of whether they passed the second-order Theory of Mind test or not.

Conclusions:
This study is the first to demonstrate the benefits of prosodic and visual cues in irony comprehension, without reliance on second-order Theory of Mind, for Mandarin-speaking children with cochlear implants. It implies potential insights for utilizing prosodic and visual cues in intervention strategies to promote irony comprehension.
SkatingVerse: A large‐scale benchmark for comprehensive evaluation on human action understanding
Authors: Gan Ziliang , Jin Lei , Cheng Yi , Cheng Yu , Teng Yinglei , Li Zun , Li Yawen , Yang Wenhan , Zhu Zheng , Xing Junliang , Zhao Jian 
Published: May 2024

AbstractHuman action understanding (HAU) is a broad topic that involves specific tasks, such as action localisation, recognition, and assessment. However, most popular HAU datasets are bound to one task based on particular actions. Combining different but relevant HAU tasks to establish a unified action understanding system is challenging due to the disparate actions across datasets. A large‐scale and comprehensive benchmark, namely SkatingVerse is constructed for action recognition, segmentation, proposal, and assessment. SkatingVerse focus on fine‐grained sport action, hence figure skating is chosen as the task object, which eliminates the biases of the object, scene, and space that exist in most previous datasets. In addition, skating actions have inherent complexity and similarity, which is an enormous challenge for current algorithms. A total of 1687 official figure skating competition videos was collected with a total of 184.4 h, exceeding four times over other datasets with a similar topic. SkatingVerse enables to formulate a unified task to output fine‐grained human action classification and assessment results from a raw figure skating competition video. In addition, SkatingVerse can facilitate the study of HAU foundation model due to its large scale and abundant categories. Moreover, image modality is incorporated for human pose estimation task into SkatingVerse. Extensive experimental results show that (1) SkatingVerse significantly helps the training and evaluation of HAU methods, (2) the performance of existing HAU methods has much room to improve, and SkatingVerse helps to reduce such gaps, and (3) unifying relevant tasks in HAU through a uniform dataset can facilitate more practical applications. SkatingVerse will be publicly available to facilitate further studies on relevant problems.
Study on space charge accumulation characteristics of silicone elastomer under DC voltage
Authors: Zhang Jinqiang , Li Xuebao , Sun Peng , Zhao Zhibin , Cui Xiang , Wei Xiaoguang , Tang Xinling , Jin Rui 
Published: May 2024

AbstractThe electric field distortion caused by the accumulation of space charge in the insulating dielectric is easy to lead to accelerated ageing and even breakdown. In this paper, the space charge characteristics and the interfacial electric field change with time of silicone elastomer under different polarity DC voltages are studied. The results show that the homopolar charge injection is dominant in the silicone elastomer, and the electric field threshold is less than 4 kV/mm. The accumulation of homopolar charge weakens the interfacial electric field, resulting in the reduction of charge injection, and the interfacial electric field and spatial charge distribution gradually stabilise over time. In addition, the electric field at the interface does not decrease to the charge injection field threshold when it reaches stability. A time‐varying electric field model of the metal‐dielectric interface under a direct current field is derived and a calculation method for the time of charge accumulation to stabilise is proposed, based on the Schottky injection model and the relation between current density and volume charge density. The accuracy of the model is verified by comparing it with the experimental results of the stability time of silicone elastomer. This model is used to estimate the time when space charge accumulation reaches stability by means of the electric field threshold and the interface barrier, which can provide reference for the experimental measurement of space charge.
The tangled warp of the Milky Way
Authors: Jónsson Viktor Hrannar , McMillan Paul J. 
Published: May 2024

Aims.We aim to determine the influence of the Milky Way’s warp on the kinematics of stars across the disc, and therefore measure its precession rate and line of nodes under different assumptions.Methods.We applied Jeans’ first equation to a model of a rigidly precessing warp. The predictions of these models were fitted to the average vertical velocities of stars with measured line-of-sight velocities inGaiaDR3 data. We tested models in which the warp’s line of nodes and precession speed are fixed, and models in which they are allowed to vary linearly with radius. We also tested models in which the velocity of stars radially in the disc is included in Jeans’ equation.Results.The kinematic data are best fit by models with a line of nodes that is 40° offset from the Sun’s Galactic azimuth, significantly leading the line of nodes found from the positions of stars. These models have a warp precession speed of around 13 km s−1kpc−1in the direction of Galactic rotation, close to other recent estimates. We find that including the velocity of stars radially in the disc in our kinematic model leads to a significantly worse fit to the data, and implausible warp parameters.Conclusions.The Milky Way’s warp appears to be rapidly precessing, but the structure and kinematics of the warped disc are not consistent within the approximation of a fixed, precessing, warp shape. This implies that the Milky Way’s warp is dynamically evolving, which is a challenge to models of the warp’s creation, and must be considered in the context of other known disturbances of the disc.
The research progress of syphilitic coronary heart disease
Authors: Wang Hexuan 
Published: May 2024

Background Syphilitic Cardiovascular Disease is a cardiovascular condition caused by the invasion of Treponema pallidum, the bacterium responsible for syphilis, into the human body. It encompasses a spectrum of cardiac disorders, including syphilitic aortitis, syphilitic aortic valve insufficiency, syphilitic aortic aneurysm, coronary artery stenosis, and myocardial gumma [1].
Method The research involved a comprehensive literature search in databases such as PubMed using keywords like "syphilis," "coronary heart disease," and "syphilitic coronary heart disease." Selected studies were reviewed to summarize the epidemiology, pathogenesis, clinical manifestations, and current diagnostic and treatment status of syphilitic coronary heart disease.
Result and Conclusion The research emphasizes the need to consider syphilis as a potential cause in coronary artery disease cases and highlights the clinical aspects and prognosis of syphilitic cardiovascular conditions.
Modelling and measurements of heat transfer coefficient in classroom experiments
Authors: Goev Gosho , Velinov Tzvetan 
Published: May 2024

Abstract
Thermal insulation of buildings is important because it has both ecological and social impacts. Most often, it is characterized by the so-called U-value. Heat transfer through walls includes conduction, convection, and thermal radiation. This leads to complex measurements and calculations for assessing the effectiveness of different insulating materials, and the usual methods are not suitable for classroom experiments. We propose a simple method for measuring the U-values of varied materials used in everyday life that can be performed in the classroom. It is based on measuring the temperature inside and outside a box, and the power, released by a resistance coil inside the box.
Boyle, Huygens and the ‘anomalous suspension’ of water
Authors: Chiappetta F , Meringolo C , Riccardi P , Tucci R , Bruzzese A , Prete G 
Published: May 2024

Abstract
We discuss experiments aimed at retracing some of the experiments on vacuum performed in the 17th century by Boyle and Huygens. We focus on the ‘anomalous suspension’ of water reported by Huygens in 1662. Our revisitation allows to discuss the apparent contrast between the results obtained by Boyle and Huygens. This controversy was one of the first conducted in scientific terms and offers the possibility of illustrating to the students how competitions and debates are conducted in modern science, which appears important in a period in which science is contested by antiscientific movements.