bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of unmet health-related need on suicidal behavior in Korean adults: a retrospective nationwide cohort study
Authors: Huh Youn , Huh Ju Young , Jeon Yerim , Lee Jun Hyung 
Published: June 2024

AbstractWe aimed to evaluate the association of unmet health-related need with suicidal behaviors among Korean adults. We included 26,219 adults (13,937 men and 17,788 women) aged ≥ 19 years from the Korea National Health and Nutrition Examination Survey (2015–2020). Suicidal behavior included suicidal plan and attempt. We analyzed the odds ratios and 95% confidence intervals of suicidal behaviors according to unmet health-related need via multivariable logistic regression analysis and performed stratified analyses according to sex, age, income, education, and type of insurance. Of the participants, 9.6% had unmet health-related need. Suicidal plans and attempts had 1.3% and 0.5% of the participants, respectively. The prevalence of suicidal plans and attempts was 0.9% and 0.4% among participants without unmet health-related need and 3.1% and 1.0% among those with such need, respectively. The odd ratios of suicidal plans and attempts increased significantly among participants with unmet health-related need compared to those without. In subgroup analysis, most subgroups showed similar results, except for suicidal plan and attempt in the 45–64 age group, high education, and medical care and suicidal attempt in 19–44 age group, low-income, and unmarried. Unmet health-related need was independently associated with suicidal plan and attempt. A policy alternative is needed for these associations.
Assessment of drinking water quality using Water Quality Index and synthetic pollution index in urban areas of mega city Lahore: a GIS-based approach
Authors: Latif Maria , Nasir Nimra , Nawaz Rab , Nasim Iqra , Sultan Khawar , Irshad Muhammad Atif , Irfan Ali , Dawoud Turki M. , Younous Youssouf Ali , Ahmed Zulkifl , Bourhia Mohammed 
Published: June 2024

AbstractThe aim of the present study was to assess the drinking water quality in the selected urban areas of Lahore and to comprehend the public health status by addressing the basic drinking water quality parameters. Total 50 tap water samples were collected from groundwater in the two selected areas of district Lahore i.e., Gulshan-e-Ravi (site 1) and Samanabad (site 2). Water samples were analyzed in the laboratory to elucidate physico-chemical parameters including pH, turbidity, temperature, total dissolved solids (TDS), electrical conductivity (EC), dissolved oxygen (DO), total hardness, magnesium hardness, and calcium hardness. These physico-chemical parameters were used to examine the Water Quality Index (WQI) and Synthetic Pollution Index (SPI) in order to characterize the water quality. Results of th selected physico-chemical parameters were compared with World Health Organization (WHO) guidelines to determine the quality of drinking water. A GIS-based approach was used for mapping water quality, WQI, and SPI. Results of the present study revealed that the average value of temperature, pH, and DO of both study sites were within the WHO guidelines of 23.5 °C, 7.7, and 6.9 mg/L, respectively. The TDS level of site 1 was 192.56 mg/L (within WHO guidelines) and whereas, in site 2 it was found 612.84 mg/L (higher than WHO guidelines), respectively. Calcium hardness of site 1 and site 2 was observed within the range from 25.04 to 65.732 mg/L but, magnesium hardness values were higher than WHO guidelines. The major reason for poor water quality is old, worn-out water supply pipelines and improper waste disposal in the selected areas. The average WQI was found as 59.66 for site 1 and 77.30 for site 2. Results showed that the quality of the water was classified as “poor” for site 1 and “very poor “ for site 2. There is a need to address the problem of poor water quality and also raise the public awareness about the quality of drinking water and its associated health impacts.
Construction of a nomogram for predicting HNSCC distant metastasis and identification of EIF5A as a hub gene
Authors: Chen Xin , Zhang Ying , Chen Sheng , Yang Yan , Sun Guowen , Pan Peng 
Published: June 2024

AbstractPatients with distant metastasis of head and neck squamous cell carcinoma (HNSCC) often have a poor prognosis. However, early diagnosis of distant metastasis is challenging in clinical practice, and distant metastasis is often only detected in the late stages of tumor metastasis through imaging techniques. In this study, we utilized data from HNSCC patients collected from the TCGA database. Patients were divided into distant metastasis and nonmetastasis groups based on the tumor–node–metastasis (TNM) stage. We analyzed the differentially expressed genes between the two groups (DM/non-M DEGs) and their associated lncRNAs and generated a predictive model based on 23 lncRNAs that were significantly associated with the occurrence of distant metastasis in HNSCC patients. On this basis, we built a nomogram to predict the distant metastasis of HNSCC patients. Moreover, through WGCNA and Cytoscape software analysis of DM/non-M DEGs, we identified the gene most closely related to HNSCC distant metastasis: EIF5A. Our findings were validated using GEO data; EIF5A expression was significantly increased in the tumor tissues of HNSCC patients with distant metastasis. We then predicted miRNAs that can directly bind to EIF5A via the TargetScan and miRWalk websites, intersected them with differentially expressed miRNAs in the two groups from the TCGA cohort, and identified the only overlapping miRNA, miR-424; we predicted the direct binding site of EIF5A and miR-424 via the miRWalk website. Immunohistochemistry further revealed high expression of EIF5A in the primary tumor tissue of HNSCC patients with distant metastasis. These results provide a new perspective for the early diagnosis of distant metastasis in HNSCC patients and the study of the mechanisms underlying HNSCC distant metastasis.
Beehive scale-free emergent dynamics
Authors: Shpurov Ivan , Froese Tom , Chialvo Dante R. 
Published: June 2024

AbstractIt has been repeatedly reported that the collective dynamics of social insects exhibit universal emergent properties similar to other complex systems. In this note, we study a previously published data set in which the positions of thousands of honeybees in a hive are individually tracked over multiple days. The results show that the hive dynamics exhibit long-range spatial and temporal correlations in the occupancy density fluctuations, despite the characteristic short-range bees’ mutual interactions. The variations in the occupancy unveil a non-monotonic function between density and bees’ flow, reminiscent of the car traffic dynamic near a jamming transition at which the system performance is optimized to achieve the highest possible throughput. Overall, these results suggest that the beehive collective dynamics are self-adjusted towards a point near its optimal density.
Altered salivary microbiota associated with high-sugar beverage consumption
Authors: Fan Xiaozhou , Monson Kelsey R. , Peters Brandilyn A. , Whittington Jennifer M. , Um Caroline Y. , Oberstein Paul E. , McCullough Marjorie L. , Freedman Neal D. , Huang Wen-Yi , Ahn Jiyoung , Hayes Richard B. 
Published: June 2024

AbstractThe human oral microbiome may alter oral and systemic disease risk. Consuming high sugar content beverages (HSB) can lead to caries development by altering the microbial composition in dental plaque, but little is known regarding HSB-specific oral microbial alterations. Therefore, we conducted a large, population-based study to examine associations of HSB intake with oral microbiome diversity and composition. Using mouthwash samples of 989 individuals in two nationwide U.S. cohorts, bacterial 16S rRNA genes were amplified, sequenced, and assigned to bacterial taxa. HSB intake was quantified from food frequency questionnaires as low (< 1 serving/week), medium (1–3 servings/week), or high (> 3 servings/week). We assessed overall bacterial diversity and presence of specific taxa with respect to HSB intake in each cohort separately and combined in a meta-analysis. Consistently in the two cohorts, we found lower species richness in high HSB consumers (> 3 cans/week) (p = 0.027), and that overall bacterial community profiles differed from those of non-consumers (PERMANOVA p = 0.040). Specifically, presence of a network of commensal bacteria (Lachnospiraceae, Peptostreptococcaceae, and Alloprevotella rava) was less common in high compared to non-consumers, as were other species including Campylobacter showae, Prevotella oulorum, and Mycoplasma faucium. Presence of acidogenic bacteria Bifodobacteriaceae and Lactobacillus rhamnosus was more common in high consumers. Abundance of Fusobacteriales and its genus Leptotrichia, Lachnoanaerobaculum sp., and Campylobacter were lower with higher HSB consumption, and their abundances were correlated. No significant interaction was found for these associations with diabetic status or with microbial markers for caries (S. mutans) and periodontitis (P. gingivalis). Our results suggest that soft drink intake may alter the salivary microbiota, with consistent results across two independent cohorts. The observed perturbations of overrepresented acidogenic bacteria and underrepresented commensal bacteria in high HSB consumers may have implications for oral and systemic disease risk.
Psychometric assessment of the 10-item Thai version of the Experience in Close Relationship-Revised for Adolescents (ECR-R-10-AD)
Authors: Wongpakaran Tinakon , DeMaranville Justin , Wongpakaran Nahathai , Wedding Danny 
Published: June 2024

AbstractThe 18-item version of the Experiences in Close Relationships-revised (ECR-R-18) is a valid and reliable scale used among Thai adolescents. However, it revealed problematic items that impacted the scale’s internal consistency. The study aimed to achieve two objectives: (1) develop a new, shorter scale by retaining only highly loaded items equally between attachment anxiety and attachment avoidance, and (2) evaluate the psychometric properties of the shorter ECR-R version compared to the existing 18-item scale. Objective 1 was achieved through Study 1, involving 204 youths aged 16–18 years (64% female). All participants completed the 18-item ECR-R, and exploratory factor analysis was conducted to identify suitable items for the new ECR-R-AD. Objective 2 was fulfilled in Study 2, which included a total of 443 students in grades aged 15–18 years old (88% female) from Thai boarding schools in Northern Thailand. All participants completed both the 18-item ECR-R, and confirmatory factor analysis of both the existing 18-item and the new shorter scale was performed and compared. Additional measures including the Rosenberg Self-Esteem Scale, Perceived Stress Scale-10, and Relationship Questionnaire were completed alongside the ECR-R to assess convergent, discriminant, and criterion validity. The invariance test for the new ECR-R across genders was conducted using multigroup confirmatory factor analysis. For objective 1, Study 1 developed a new scale called "ECR-R-10-AD" with 10 items, comprising 5 for attachment anxiety and 5 for attachment avoidance. The McDonald’s omega values were 0.866 for avoidance and 0.823 for anxiety subscales. The corrected correlation between the ECR-R-18 and ECR-R-10-AD was significant. For objective 2, Study 2 found that the first-order two-factor solution model fit the data best for the ECR-R-10-AD. Convergent, discriminant, and criterion validity with other measurements and invariance tests based on sex were established for the ECR-R-AD. The ECR-R-10-AD provided sufficient psychometric properties among Thai adolescents. Factorial validity, convergent validity, and measurement invariance were established. As the ECR-R-10-AD is brief, it can be administered with less burden. Limitations and future research were discussed.
Bronze age Northern Eurasian genetics in the context of development of metallurgy and Siberian ancestry
Authors: Childebayeva Ainash , Fricke Fabian , Rohrlach Adam Benjamin , Huang Lei , Schiffels Stephan , Vesakoski Outi , Mannermaa Kristiina , Semerau Lena , Aron Franziska , Solodovnikov Konstantin , Rykun Marina , Moiseyev Vyacheslav , Khartanovich Valery , Kovtun Igor , Krause Johannes , Kuzminykh Sergey , Haak Wolfgang 
Published: June 2024

AbstractThe Eurasian Bronze Age (BA) has been described as a period of substantial human migrations, the emergence of pastoralism, horse domestication, and development of metallurgy. This study focuses on two north Eurasian sites sharing Siberian genetic ancestry. One of the sites, Rostovka, is associated with the Seima-Turbino (ST) phenomenon (~2200-1900 BCE) that is characterized by elaborate metallurgical objects found throughout Northern Eurasia. The genetic profiles of Rostovka individuals vary widely along the forest-tundra Siberian genetic cline represented by many modern Uralic-speaking populations, and the genetic heterogeneity observed is consistent with the current understanding of the ST being a transcultural phenomenon. Individuals from the second site, Bolshoy Oleni Ostrov in Kola, in comparison form a tighter cluster on the Siberian ancestry cline. We further explore this Siberian ancestry profile and assess the role of the ST phenomenon and other contemporaneous BA cultures in the spread of Uralic languages and Siberian ancestry.
Activation of the cell wall integrity pathway negatively regulates TORC2-Ypk1/2 signaling through blocking eisosome disassembly in Saccharomyces cerevisiae
Authors: Nomura Wataru , Inoue Yoshiharu 
Published: June 2024

AbstractThe target of rapamycin complex 2 (TORC2) signaling is associated with plasma membrane (PM) integrity. In Saccharomyces cerevisiae, TORC2-Ypk1/2 signaling controls sphingolipid biosynthesis, and Ypk1/2 phosphorylation by TORC2 under PM stress conditions is increased in a Slm1/2-dependent manner, under which Slm1 is known to be released from an eisosome, a furrow-like invagination PM structure. However, it remains unsolved how the activation machinery of TORC2-Ypk1/2 signaling is regulated. Here we show that edelfosine, a synthetic lysophospholipid analog, inhibits the activation of TORC2-Ypk1/2 signaling, and the cell wall integrity (CWI) pathway is involved in this inhibitory effect. The activation of CWI pathway blocked the eisosome disassembly promoted by PM stress and the release of Slm1 from eisosomes. Constitutive activation of TORC2-Ypk1/2 signaling exhibited increased sensitivity to cell wall stress. We propose that the CWI pathway negatively regulates the TORC2-Ypk1/2 signaling, which is involved in the regulatory mechanism to ensure the proper stress response to cell wall damage.
Unsupervised manifold embedding to encode molecular quantum information for supervised learning of chemical data
Authors: Li Tonglei , Huls Nicholas J. , Lu Shan , Hou Peng 
Published: June 2024

AbstractMolecular representation is critical in chemical machine learning. It governs the complexity of model development and the fulfillment of training data to avoid either over- or under-fitting. As electronic structures and associated attributes are the root cause for molecular interactions and their manifested properties, we have sought to examine the local electron information on a molecular manifold to understand and predict molecular interactions. Our efforts led to the development of a lower-dimensional representation of a molecular manifold, Manifold Embedding of Molecular Surface (MEMS), to embody surface electronic quantities. By treating a molecular surface as a manifold and computing its embeddings, the embedded electronic attributes retain the chemical intuition of molecular interactions. MEMS can be further featurized as input for chemical learning. Our solubility prediction with MEMS demonstrated the feasibility of both shallow and deep learning by neural networks, suggesting that MEMS is expressive and robust against dimensionality reduction.
An Ediacaran orogeny in subglacial East Antarctica is uncovered by detrital garnet geochronology
Authors: Verhaert Sharmaine , Glorie Stijn , Hand Martin , Mulder Jacob A. , Milnes Anthony R. , Halpin Jacqueline A. 
Published: June 2024

AbstractDetrital minerals provide valuable insights into the tectonic history of continents. Uranium-lead dating of detrital zircon is widely used to characterize the magmatic history of continents but is generally insensitive to metamorphism accompanying the production and reworking of crust during orogenesis. Garnet is the most important mineral for recording prograde and peak orogenic metamorphism and can occur as a common detrital phase. Here, we demonstrate laser-ablation lutetium-hafnium (Lu-Hf) geochronology of detrital garnet as a provenance tool for reconstructing orogenic histories at (super)continental scales. Detrital garnet (n = 557) from modern sands and Permo-Carboniferous glacial strata in South Australia faithfully record local garnet-grade metamorphic events but also include a major population at ca. 590 million-years with no known source in South Australia. We trace the ca. 590 million-year-old detrital garnets to a largely ice-covered orogenic province in East Antarctica, uncovering the inception of convergent margin tectonism along the palaeo-Pacific margin of Gondwana.
Understanding how space travel affects the female reproductive system to the Moon and beyond
Authors: Mathyk Begum , Imudia Anthony N. , Quaas Alexander M. , Halicigil Cihan , Karouia Fathi , Avci Pinar , Nelson Nicolas G. , Guzeloglu-Kayisli Ozlem , Denbo Miriah , Sanders Lauren M. , Scott Ryan T. , Basar Murat , Guevara-Cerdán Ana Paula , Strug Michael , Monseur Brent , Kayisli Umit A. , Szewczyk Nathaniel , Mason Christopher E. , Young Steven L. , Tasoglu Savas , Costes Sylvain V. , Beheshti Afshin 
Published: June 2024

AbstractAs the space industry grows exponentially and aspirations for space travel expand, we are entering a new era where we will very likely become an interplanetary species. Although reproduction is an essential human function and necessary for species survival, we have remarkably little knowledge regarding the impact of space travel on the female reproductive system. The effects of spaceflight on human reproductive potential, fertility, implantation and subsequent pregnancy resulting in a healthy live birth must be considered before planning prolonged spaceflight missions and the colonization of planets. In this review, we explore what is known and what remains to be learned about the effects of space travel on female reproductive endocrinology. We also delve deeper into reproductive endocrinology and discuss normal physiologic mechanisms at the molecular level to have a better understanding of how it may change during spaceflight. The rigors of spaceflight including radiation, gravitational stressors, and circadian rhythm changes could potentially affect ovulation, fertilization, endometrial receptivity, preimplantation embryo development, embryo implantation, placentation, and pregnancy. Thus, we will examine what is known about spaceflight effects on the hypothalamic–pituitary–gonadal (HPG) axis, ovarian folliculogenesis and steroidogenesis, early embryogenesis, endometrial receptivity, and pregnancy. We further discuss the recent advances in reproductive endocrinology and future research platforms. Establishing a better understanding of the effect of space travel on female reproductive health, as well as developing countermeasures to mitigate adverse effects, are decisive components of our species’ successful transition to an interplanetary one.
Initial state‐dependent implementation of logic gates with memristive neurons
Authors: Rajki Franciska , Horváth András , Ascoli Alon , Tetzlaff Ronald 
Published: June 2024

AbstractThis study introduces a simple memristor cellular neural network structure, a minimalist configuration with only two cells, designed to concurrently address two logic problems. The unique attribute of this system lies in its adaptability, where the nature of the implemented logic gate, be it AND, OR, and XOR, is determined exclusively by the initial states of the memristors. The memristors' state, alterable through current flow, allows for dynamic manipulation, enabling the setting of initial conditions and consequently, a change in the circuit's functionality. To optimize the parameters of this dynamic system, contemporary machine learning techniques are employed, specifically gradient descent optimization. Through a case study, the potential of leveraging intricate circuit dynamics is exemplified to expand the spectrum of problems solvable with a defined number of neurons. This work not only underscores the significance of adaptability in logical circuits but also demonstrates the efficacy of memristive elements in enhancing problem‐solving capabilities.
Model‐driven neural network based for HPO‐MIMO channel estimation
Authors: Gong Yi , Liu Yujia , Meng Fanke , Xu Zhan 
Published: June 2024

AbstractIntegrated Sensing and Communications (ISAC) need to process data streams in high‐speed sensor data acquisition or high‐speed wireless communications. To process the data can require more computing and communication resources, resulting in higher power consumption. Halved‐Phase Only Multiple Input Multiple Output (HPO‐MIMO) communication technology can solve this problem by using low‐power nonlinear detection devices. In ISAC, Channel Estimation (CE) technology can provide key channel characteristics and state information for sensing and collaborative work of perception and communication tasks. However, HPO‐MIMO system cannot realize CE using traditional receiver schemes because of the missing amplitude. In order to solve this problem, two HPO‐MIMO CE schemes based on model‐driven deep learning are proposed in this paper. The proposed schemes include a Densely Residual Network (DRN) and a Inception‐Resnet (IR), which is suitable for the case of sufficient data and insufficient data, respectively. The simulation results show that the performance of DRN based scheme is better than that of IR based scheme when the data amount is sufficient, and the performance of IR based scheme is better when the dataset is small. In addition, the proposed CE schemes work well with a range of antenna sizes and distances.