bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Total Synthesis of (+)‐A83586C, (+)‐Kettapeptin and (+)‐Azinothricin: Powerful New Inhibitors of β‐Catenin/TCF4‐ and E2F‐Mediated Gene Transcription
Authors: Hale Karl J. , Manaviazar Soraya , George Jonathan 
Published: September 2010

AbstractReview: 113 refs.
ChemInform Abstract: Supramolecular Chemistry
Authors: Dighe Nachiket S. , Pattan Shashikant R. , Musmade Deepak S. , Dengale Santosh S. , Kalkotwar Ramesh S. , Gaware Vinayak M. , Hole Mangesh B. 
Published: September 2010

AbstractReview: 23 refs.
μ‐Consortium: Installation of a mobile Plant for Education and Training in Micro Process Engineering
Authors: Knochen J. , Kunz U. , Turek T. , Ceylan S. , Kirschning A. , Kampen I. , Vielkind M. , Kwade A. , Arndt S. , Scholl S. 
Published: September 2010

AbstractIm Rahmen des Projekts μ‐Consortium wurde eine mobile Praktikumsanlage zur Einbindung der Mikroverfahrenstechnik in die Lehre realisiert. Zur Vermittlung von Kenntnissen in einer Vielzahl verfahrenstechnischer Operationen im Mikromaßstab wurden Praktikumsversuche zu den Themengebieten Mischen und homogene Reaktion, heterogene Reaktionen, Wärmeübertragung und Partikelsynthese entwickelt.
Synthesis of Cyclopropane‐containing Building Blocks via Ir‐Catalyzed Enantioselective Allylic Substitution Reaction
Authors: Xia Jibao , Zhuo Chunxiang , You Shuli 
Published: September 2010

AbstractChiral cyclopropane‐containing building blocks, which are very important synthetic intermediates for natural products or pharmaceuticals, were easily synthesized via Ir‐catalyzed enantioselective allylic substitution reaction.
Self‐Assembly of Vesicles by a 2,6‐Di(7‐benzamidy)quinolin‐2‐ yl)pyridine Derivative Tuned by an Amphiphilic Amide Chain
Authors: You Liyan , Zhao Xin , Li Zhanting 
Published: September 2010

AbstractThis paper describes 2‐(2‐(dioctylamino)‐2‐oxoethyl‐amino)‐2‐oxoethoxyl (DOAOE)‐tuned self‐assembly of vesicles from a 2,6‐di(7‐benzamidy)‐quinolin‐2‐yl)pyridine derivative. Scanning electron (SEM), transmission electron (TEM) and optical microscopy and dynamic light scattering (DLS) studies reveal that the molecule self‐assembles into vesicular structures in methanol. The influence of the transition metal ions and trifluoroacetic acid on the formation of the vesicles was investigated. The results illustrate that DOAOE is robust in promoting the formation of vesicles for aromatic systems in polar medium.
Dehydrogenation of Propane to Propylene over Ga2O3Supported on Mesoporous HZSM‐5 in the Presence of CO2
Authors: Xie Yuqing , Hua Weiming , Yue Yinghong , Gao Zi 
Published: September 2010

AbstractDehydrogenation of propane to propylene over mesoporous HZSM‐5 supported Ga2O3 catalysts in the presence of CO2 has been investigated, and compared with that of conventional HZSM‐5 supported one. The initial activity of the catalysts descends while the stability and selectivity to propylene improve with increasing the Si/Al ratios of the support. The optimal Si/Al ratio is 240 for the propylene yield reaching 21.7% after reaction for 50 h. The introduction of the mesopores improves the activity as well as the stability of the catalyst, due to the better transport of the reactant and product molecules caused by its hierarchical structure. The selectivity for bulky products such as aromatics is also increased. The promoting effect of CO2 on the dehydrogenation reaction is observed.
Solid‐state Supramolecular Architectures by p‐Sulfonatocalix[4]arene with Bispyridinium Derivatives
Authors: Zhang Jie , Guo Dongsheng , Liu Yu 
Published: September 2010

AbstractTwo supramolecular structures were obtained by inclusion complexation of p‐sulfonatocalix[4]arene with 1,2‐bis(pyridinium)ethane and 1,2‐bis(4,4′‐dipyridinium)ethane in single‐crystal form, which have been examined from the aspects of binding mode, stoichiometry and extended structure. Effects of guest molecules, especially charges and terminal groups, on host conformation, binding and extended structures were carefully compared and summarized.
Multi‐target QSAR Study in the Analysis and Design of HIV‐1 Inhibitors
Authors: Liu Qi , Che Dongsheng , Huang Qi , Cao Zhiwei , Zhu Ruixin 
Published: September 2010

AbstractThe multi‐target quantitative structure‐activity relationship (QSAR) study of human immunodeficiency virus (HIV‐1) inhibitors was addressed by applying a simple, yet effective linear regression model based on the multi‐task learning paradigm. QSAR studies were performed on three datasets of HIV‐1 inhibitors targeted on protease, integrase and reverse transcriptase, respectively. By using the multi‐task learning method, the synergy among different set of inhibitors was exploited and an efficient multi‐target QSAR modeling for HIV‐1 inhibitors was obtained. The general descriptor features and drug‐like features for compound description were ranked according to their jointly importance in multi‐target QSAR modeling, respectively. A SAReport for investigating the relationships between compound structures and binding affinities was presented based on our multiple target analysis, which is expected to provide useful clues for the design of novel multi‐target HIV‐1 inhibitors with increasing likelihood of successful therapies.
A Ladder‐like One‐dimensional Chain Based on a New Biradical and CuII: Crystal Structure and Magnetic Properties
Authors: Wang Chao , Ma Yue , Yang Xi , Yan Shiping , Liao Daizheng 
Published: September 2010

AbstractA new biradical di(4‐(1′‐oxyl‐3′‐oxido‐4′,4′,5′,5′‐tetramethyl‐4′,5′‐dihydro‐1′H‐imidazol‐2′‐yl)phenyl) ether (1) and its copper complex 2 were synthesized and characterized structurally. The X‐ray structure determination revealed that, the complex is in the triclinic P‐1 space group and displays a ladder‐like structure. Each copper atom is surrounded by four oxygen atoms from hexafluoroacetylacetone and two oxygen atoms from biradical. The magnetic measurements show that biradical 1 exhibits a weak intramolecular nitroxide‐nitroxide antiferromagnetic coupling and copper complex 2 possesses weak ferromagnetic coupling (J=5.09 cm−1) between CuII and radical, which attributed to interaction between copper spin and the axially coordinated nitronyl nitroxide spin.
Solvothermal Synthesis and Magnetic Property of Magnetic Chains Self‐assembled by Fe3O4 Microoctahedrons
Authors: Zhang Junhao , Wan Jun , Huang Shaoxing , Du Jin , Zhu Jia , Zhang Dongjing , Yin Qinghuan , Wu Yuhui 
Published: September 2010

AbstractThe magnetic Fe3O4 microscale chains self‐assembled of microoctahedrons have been synthesized via a facile one‐pot solution‐phase route at 200°C. The result of X‐ray diffraction (XRD) indicates that the product is face‐centered cubic Fe3O4 and has highly crystalline nature. Field‐emission scanning electron microscopy (FESEM) and transmission electron microscope (TEM) images show that the product consists of larger numbers of Fe3O4 microoctahedrons chains, and the size of microoctahedrons is from 1 to 3 μm. The effect of NaOH concentration and solvent on the morphologies of the products indicates that appropriate alkaline surrounding and solvent may be propitious to the formation of the uniform Fe3O4 microoctahedrons chains. The magnetic measurements at room temperature indicate that the values of saturation magnetization (85.6 emu/g) and coercivity (65.2 Oe) are different from those of dispersed microoctahedrons due to the different size and the oriented self‐assembled structure of microoctahedrons.
An Elimination Approach to the Synthesis of (+)‐Scorodonin
Authors: Zhang Yan , Wu Yikang 
Published: September 2010

Abstract1,2‐Elimination of optically‐active vinyl sulfoxide‐allylic acetates led to corresponding allenynes in excellent yields. When the chirality of the sulfinyl group "matched" that at the allylic position, the chirality at the allylic stereogenic center could be efficiently transferred to the allenic axis.
Studies on Synthesis of the C‐1 to C‐18 Fragment of Pamamycins 607 and 621A
Authors: Ren Guobao , Wu Yikang 
Published: September 2010

AbstractSome efforts directed towards synthesis of the C‐1 to C‐18 fragment of natural antibiotic pamamycins 607 and 621A are disclosed. The nine stereogenic centers in the fragment were installed using a chiral auxiliary‐induced asymmetric aldol reaction, a chiral building block derived from malic acid, or substrate chirality‐induced asymmetric reduction of a ketone carbonyl group.
A Simple and Sensitive Piezoelectric Immunosensor for Cholera Toxin Based on GM1‐Incorporated Liposome Agglutination
Authors: Li Yu , Wang Yuansheng , Yu Hongwei , Jiang Jianhui , Kong Rongmei , Shen Guoli , Yu Ruqin 
Published: September 2010

AbstractA sensitive piezoelelctric immunosensor has been developed for the direct detection of cholera toxin. The proposed technique is based on specific interface agglutination of GM1 incorporated liposome vesicles in the presence of the cholera toxin, which causes a frequency change and is monitored by a piezoelectric device. The interface agglutination reaction would take place as soon as the cholera toxin (CT) was captured by the antibodies modified on the probe surface and the GM1 incorporated liposome in the probe cell. Meanwhile, the agglutination reaction induced both the mass effect and viscoelastic effect acting on the probe surface. The results indicate that the probe signal can be observably multiplied. In addition, an optimization of liposome composition and assay medium were investigated. Moreover, no cross‐reactivates were observed with the common protein, such as goat anti‐mouse IgG (1 mg/mL), mouse IgG (1 mg/mL), goat anti‐human IgG (1 mg/mL), and thrombin (1 mg/mL). The frequency responses of the developed piezoelelctric immunosensor are linearly correlated to cholera toxin concentration in the range of 0.5 to 7.5 µg/mL with a detection limit of 0.27 µg/mL while showed no significant loss in activity over 3 d under storage at 4°C.
An Efficient and Practical Synthesis of Benzoxazoles from Acyl Chlorides and 2‐Aminophenols Catalyzed by Lewis Acid In(OTf)3 under Solvent‐Free Reaction Conditions
Authors: Wang Bo , Zhang Yicheng , Li Pinhua , Wang Lei 
Published: September 2010

AbstractBenzoxazole derivatives have been prepared through the reaction of substituted 2‐aminophenols and acyl chlorides in the presence of catalytic amount of In(OTf)3 under solvent‐free reaction conditions in good to excellent yields. The method is simple, convenient, environmental‐friendly, efficient and practical.
Zinc(II)‐Catalyzed Mannich‐type Reactions of Hydrazones with Difluoroenoxysilane and Its Application in the Synthesis of Optically Active 2,2‐Difluoro‐3‐oxo‐benzohydrazide
Authors: Yuan Zhiliang , Wei Yin , Shi Min 
Published: September 2010

AbstractWith the catalysis of Zn(OTf)2, Mannich‐type reactions of various aromatic hydrazones 1 with difluoroenoxysilane 2 proceeded smoothly to produce 2,2‐difluoro‐3‐oxo‐benzohydrazides in 27% –78% yields in THF or DCM under mild conditions. An unexpected monofluorination of hydrazone 1m with difluoroenoxysilane 2 was also disclosed in this paper. The first example of the asymmetric Mannich‐type reaction of hydrazone 1a with difluoroenoxysilane 2 using chiral phosphine‐oxazoline ligand has been reported, giving the adduct 3a in good yields and moderate enantioselectivities under mild conditions.
Arg/Abl‐binding protein, a Z‐body and Z‐band protein, binds sarcomeric, costameric, and signaling molecules
Authors: Sanger Jean M. , Wang Jushuo , Gleason Lisa M. , Chowrashi Prokash , Dube Dipak K. , Mittal Balraj , Zhukareva Victoria , Sanger Joseph W. 
Published: September 2010

AbstractArgBP2 (Arg/Abl‐Binding Protein) is expressed at high levels in the heart and is localized in the Z‐bands of mature myofibrils. ArgBP2 is a member of a small family of proteins that also includes vinexin and CAP (c‐Cbl‐associated protein), all characterized by having one sorbin homology (SOHO) domain and three C‐terminal SH3 domains. Antibodies directed against ArgBP2 also react with the Z‐bodies of myofibril precursors: premyofibrils and nascent myofibrils. Expression in cardiomyocytes of plasmids encoding Yellow Fluorescent Protein (YFP) fused to either full length ArgBP2, the SOHO, mid‐ArgBP or the SH3 domains of ArgBP2 led to Z‐band targeting of the fusion proteins, whereas an N‐terminal fragment lacking these domains did not target to Z‐bands. Although ArgBP2 is not found in skeletal muscle cells, YFP‐ArgBP2 did target to Z‐bodies and Z‐bands in cultured myotubes. GST‐ArgBP2‐SH3 bound actin, α‐actinin and vinculin proteins in blot overlays, cosedimentation assays, and EM negative staining techniques. Over‐expression of ArgBP2 and ArgBP2‐SH3 domains, but not YFP alone, led to loss of myofibrils in cardiomyocytes. Fluorescence recovery after photobleaching was used to measure the rapid dynamics of both the full length and some truncated versions of ArgBP2. Our results indicate that ArgBP2 may play an important role in the assembly and maintenance of myofibrils in cardiomyocytes. © 2010 Wiley‐Liss, Inc.
Immune modulation of minimal residual disease in early chronic phase chronic myelogenous leukemia
Authors: Cortes Jorge , Quintás‐Cardama Alfonso , Jones Dan , Ravandi Farhad , Garcia‐Manero Guillermo , Verstovsek Srdan , Koller Charles , Hiteshew Jody , Shan Jenny , O'Brien Susan , Kantarjian Hagop 
Published: September 2010

AbstractBACKGROUND:Most patients with chronic myelogenous leukemia (CML) harbor residual disease, as evidenced by molecular techniques even after treatment with high‐dose imatinib (ie, 800 mg/d). Interferon alpha (IFN α) is efficacious in CML likely due to its immunomodulatory properties, and is synergistic in vitro with imatinib and granulocyte macrophage‐colony stimulating factor (GM‐CSF).METHODS:A study was undertaken to determine whether adding pegylated (PEG) IFN α‐2b and GM‐CSF to high‐dose imatinib may improve the complete molecular response rate in patients with CML in chronic phase. Ninety‐four patients were treated with imatinib 800 mg/d for the first 6 months, then randomly assigned to continue high‐dose imatinib alone (n = 49) or in combination with PEG IFN α‐2b 0.5 μg/kg/wk and GM‐CSF 125 mg/m2 3× weekly (n = 45).RESULTS:The median follow‐up for all patients was 54 months (range, 7‐70 months). There were no differences in the rates of complete cytogenetic response (87% vs 90%; P = 1.0), or of major (77% vs 77%; P = 1.0) or complete (11% vs 13%; P = 1.0) molecular response (on the international scale) at 12 months between the 2 arms, or at any time during the study. Adverse events led to PEG IFN α‐2b discontinuation in all patients.CONCLUSIONS:The addition of PEG IFN α‐2b and GM‐CSF to high‐dose imatinib therapy does not improve significantly the cytogenetic or molecular response rates compared with high‐dose imatinib alone. The high dropout rate in the PEG IFN α‐2b arm may have compromised its potential immunomodulatory benefit. Cancer 2011. © 2010 American Cancer Society.
Reporting time‐to‐event endpoints and response rates in 4 decades of randomized controlled trials in advanced colorectal cancer
Authors: Arkenau Hendrik‐Tobias , Nordman Ina , Dobbins Timothy , Ward Robyn 
Published: September 2010

AbstractBACKGROUND:Reporting of randomized controlled clinical trials (RCTs) often is suboptimal. Cancer drug trials are complicated further by multiple survival and response endpoints. The authors of this report determined the frequency of reporting of time‐to‐event endpoints and tumor response outcomes in advanced colorectal cancer and examined the relation between the year of publication and the reported effectiveness of 5‐fluorouracil or equivalent agents.METHODS:A literature search identified 144 RCTs that involved 35,853 patients. The patient characteristics, trial designs, and methods for endpoint reporting were extracted. The clinical effectiveness of 5‐fluorouracil or equivalent agents was analyzed in 3 time periods (pre‐1990, 1990s, and 2000s) in 28,636 patients.RESULTS:One hundred twenty‐nine trials (90%) reported overall survival (OS) and response rates; whereas time to progression (44%), duration of response (43%), progression‐free survival (22%), and time to treatment failure (12%) were reported less frequently. Except for stable and progressive disease, the frequency of reporting of endpoints did not improve over the period studied. The median OS for patients who received 5‐fluorouracil or equivalent agents increased significantly (from 9.4 months before 1990 to 13.5 months after 2000). During the same period, the rate of stable disease increased (38.2%, 40.5%, and 45.1% for pre‐1990, 1990s, and 2000s, respectively; P = .004); whereas the rate of progressive disease decreased significantly (39.2%, 33.3%, and 27.8%, respectively; P = .002).CONCLUSIONS:Its likely that the increasing availability of alternative treatments and better supportive care improved OS, whereas the rates of stable and progressive disease altered because of changes in follow‐up schedules. Other intermediate endpoints (duration of response and time to progression) remained largely constant over the time course of the current study, making them superior benchmarks for comparison with future studies. Cancer 2011. © 2010 American Cancer Society.
A Distinctive layering pattern of mouse dentate granule cells is generated by developmental and adult neurogenesis
Authors: Mathews Emily A. , Morgenstern Nicolás A. , Piatti Verónica C. , Zhao Chunmei , Jessberger Sebastian , Schinder Alejandro F. , Gage Fred H. 
Published: September 2010

AbstractRetroviral labeling of granule cells of the adult mouse reveals an outside‐in layering based on birthdate. Green–granule cells labeled by retrovirus CAG–GFP at E15. Magenta–granule cells labeled by retrovirus CAG‐RFP at P42. The Journal of Comparative Neurology, Volume 518, Number 22, 4479–4490.
Acid‐Catalyzed Dehydration of Fructose and Inulin with Glycerol or Glycerol Carbonate as Renewably Sourced Co‐Solvent
Authors: Benoit Maud , Brissonnet Yoan , Guélou Erwan , De Oliveira Vigier Karine , Barrault Joël , Jérôme François 
Published: September 2010

AbstractIonic liquids (ILs) can be partially substituted by glycerol or glycerol carbonate as cheap, safe, and renewably sourced co‐solvents in the acid‐catalyzed dehydration of fructose and inulin to 5‐hydroxymethylfurfural (HMF). In the particular case of glycerol, we found that HMF can be conveniently extracted from the IL/glycerol (65:35) mixture with methylisobutylketone, limiting the reactivity of glycerol with HMF and allowing the recovery of HMF with a high purity (95 %). Influences of the fructose content, temperature, and the nature of the ionic liquid are also discussed. The possible use of industrial‐grade glycerin is also investigated. We demonstrate that by using glycerol carbonate, up to 90 wt % of the IL can be successfully substituted, decreasing the environmental costs of traditional IL‐based processes.
Measurements of Mode Structure of Shear‐Modified Drift Wave Using Y‐ and Γ‐ Shaped Electrostatic Probes
Authors: Kaneko T. , Hatakeyama R. 
Published: September 2010

AbstractMode structures of drift‐wave instabilities modified by a field‐aligned flow velocity shear are investigated, where axial and azimuthal wave numbers are measured using Y‐shaped and Γ‐shaped electrostatic probes, respectively. When the ion flow velocity shear is produced by applying different bias voltages to three segments of an ion source, drift waves having azimuthal mode number m = 1, 2, and 3 are observed to be excited simultaneously. It is found that the excitation‐threshold value of the shear strength depends on the azimuthal mode number, as expected from a model based on a kinetic theory, suggesting that the observations are explained by the competition between inverse electron Landau damping and shear‐modified ion Landau damping (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Particle‐In‐Cell Simulations of the Ball‐Pen Probe
Authors: Komm M. , Adamek J. , Pekarek Z. , Panek R. 
Published: September 2010

AbstractIn this paper, we present results of Particle‐In‐Cell simulations of a simplified model of the Ball‐pen probe (BPP). The BPP is a probe designed for direct measurements of plasma potential in the scrape‐off layer (SOL) of tokamaks. The probe is based on a standard Langmuir theory, which states that when the ratio of ion and electron saturation currents flowing to the probe collector approaches zero, the floating potential of the collector is close to the plasma potential. However, it is unclear whether the Langmuir theory is still valid in such a complex geometry, where the probe tunnel can work as a filter in velocity phase‐space and as such violates the Maxwellian distributions of particle velocities. To verify the validity of the theory a simplified model of BPP has been studied using the SPICE2 code (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Measurements of Plasma Properties Using Fast Sweep Langmuir Probes in Unmagnetized Weakly Ionized Plasmas
Authors: Troll O. , Conde L. , Criado E. , Donoso J. M. , Herdrich G. 
Published: September 2010

AbstractThe performances of a simple circuit for fast sweep measurements using collecting and emissive Langmuir probes are evaluated. The probes are biased by means of a time dependent ramp voltage signal with a variable pulse frequency and the current voltage curves are measured along the increasing flange of this sawtooth voltage. The response of this fast probe polarization circuit was verified under actual experimental conditions by measuring the properties of a stationary Maxwellian plasma produced by means of a glow discharge. The results are independent of the experimental conditions and essentially rely on the discharge properties for polarization pulse repetition rates below a threshold. This upper bound lies below the ion plasma frequency and is related with the faster time scale involved in the sawtooth signal probe bias voltage. The motion of ions would not follow the rapid change of the electric field around the probe associated to the short decreasing edge of the sawtooth polarization voltage and, therefore, the probe perturbs the local electric field. We conclude that these time scales should be considered for the interpretation of these measurements in addition to the electron and ion plasma frequencies in fast sweep Langmuir probe techniques. We conclude that these time scales should be considered for the interpretation of these measurements in addition to the electron and ion plasma frequencies in fast Langmuir probe techniques (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Developments of Divertor Target‐Imbedded Langmuir Probes for W7‐X
Authors: Ye M.Y. , Laux M. , Lindig S. , Laube R. , Greuner H. 
Published: September 2010

AbstractThe superconducting stellarator W7‐X equipped with a divertor is under construction at Max‐Planck institute for plasma Physics in Greifswald. It is planned to start plasma operation with the test divertor (TDU) without active cooling for shorter plasma pulse operation in 2014. The TDU has been designed to withstand thermal loads up to 8MW/m2 for pulse operation of the W7‐X. A target‐imbedded array of electrostatic probes is a useful diagnostics to measure basic plasma parameters close to the divertor targets, and has been proposed to install into the TDU plates. Especially the design of imbedded probe arrays must be optimized not only to minimize thermo‐mechanical risk for the imbedding target but also to withstand thermal loads up to 8MW/m2 during pulse operation. Finite element thermal analyses are performed to guide the design of the probe. Results and acceptable technical solutions for TDU target imbedded probe arrays are reported (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)