bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health status and quality of life among non‐Hodgkin lymphoma survivors
Authors: Smith Sophia K. , Zimmerman Sheryl , Williams Christianna S. , Zebrack Bradley J. 
Published: May 2009

AbstractBACKGROUND:A growing body of evidence suggests that long‐term survivors with 1 of the more common forms of adult cancer report a quality of life (QOL) similar to that in the general population. However, specific concerns have been identified (sexual dysfunction, fatigue, distress) in this population. Also, less is known concerning survivors of adult non‐Hodgkin lymphoma (NHL), a disease often marked by alternating periods of disease and remission. Therefore, in the current study, the authors compared the QOL status of individuals who reported having active NHL with the QOL status of individuals who were disease‐free short‐term survivors (STS) (2‐4 years postdiagnosis) and long‐term survivors (LTS) (≥5 years postdiagnosis).METHODS:Eligible survivors completed a mailed survey with validated measures, including physical and mental health status measured with the Medical Outcomes Study 36‐item Short Form, cancer‐related QOL, the Functional Assessment of Cancer Therapy‐Lymphoma module, and self‐reported impact of cancer. Other data were collected to examine as correlates.RESULTS:Seven hundred sixty‐one survivors identified from 2 North Carolina cancer registries participated. The average survivor was 10.4 years postdiagnosis (range, 2‐44 years postdiagnosis) and was age 62.7 years (range, 25‐92 years). Survivors with active disease (n = 109) demonstrated worse physical and mental health functioning, worse QOL, and less positive and more negative impacts of cancer compared with disease‐free survivors (n = 652; all P ≤ .01). No significant differences were observed between STS and LTS.CONCLUSIONS:Although survivors with NHL who had active disease reported more negative outcomes compared with off‐treatment survivors, the length of time after diagnosis did not appear to matter with regard to outcomes for STS or LTS. In addition, mixed results from comparisons with general population norms suggested the need for supportive care for this diverse survivorship group. Cancer 2009. © 2009 American Cancer Society.
A case series evaluation of a modified version of interpersonal psychotherapy (IPT) for the treatment of bulimic eating disorders: A pilot study
Authors: Arcelus Jon , Whight Debbie , Langham Christopher , Baggott Jonathan , McGrain Lesley , Meadows Lesley , Meyer Caroline 
Published: May 2009

AbstractObjectiveTo determine the therapeutic outcome of a modified form of (IPT‐BNm) amongst patients with Bulimia Nervosa (BN) and Eating Disorders Not Otherwise Specified (EDNOS).MethodFollowing initial assessment, 59 patients with diagnoses of BN or EDNOS entered treatment in the form of 16 sessions of IPT‐BNm. At initial assessment, patients completed measures of general psychopathology (SCL‐90), Self esteem (RSE), eating psychopathology (EDE‐Q), interpersonal functioning (Inventory of Interpersonal Functioning; IIP‐32) and depression (BDI). At the middle and end of treatment, EDE‐Q, IIP‐32 and BDI measures were repeated.ResultsBy the middle of therapy, patients had made significant improvements in terms of their eating disordered cognitions and behaviours (including reductions in EDE‐Q scores, bingeing and self‐induced vomiting), interpersonal functioning and levels of depression.ConclusionsIPT‐BNm is an effective treatment for patients with Bulimic Eating Disorders and appears to work quickly, as there were significant reductions in eating disorders symptoms within the first eight sessions of treatment. Copyright © 2009 John Wiley & Sons, Ltd and Eating Disorders Association.
Phylogeny of Old World Lathyrus L. (Fabaceae) based on morphological data
Authors: Leht M. 
Published: May 2009

AbstractThe genus Lathyrus is supported as a well defined genus not subdivisible into subgenera. The results of the present analysis clearly support sections Cicerula and Lathyrus s.str. with L. hirsutus in a monospecific clade, but not separation of section Gorgonia. Section Pratensis is not warranted and the taxa should belong to section Aphaca. Lathyrus roseus of section Orobon is placed within section Orobus. Section Lathyrostylis is a natural, monophyletic group according to the present analysis as well. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Zwei neue fossile Hölzer der Morphogattung Pinoxylon Knowlton emend. Read aus dem Tertiär der Insel Lesbos, Griechenland
Authors: Süss H. , Velitzelos E. 
Published: May 2009

AbstractAus dem Tertiär von Lesbos (Griechenland) werden zwei in der näheren Umgebung von Eressos gefundene Hölzer untersucht und als Pinoxylon diversiradiatum sp. nova und P. graciliradiatum sp. nova beschrieben. Die auffälligsten Merkmale beider Arten sind das Vorkommen von drei verschiedenen Holzstrahlformen: Strahlen mit nur kleinen Zellen, Strahlen mit Sekretzellen und große Strahlen mit großen idioblastenartigen Zellen. Der Bau dieser Holzstrahlen wird in einem eigenen Abschnitt besprochen. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Validierung von Subassoziationen mongolischer Pflanzengesellschaften
Authors: Hilbig W. 
Published: May 2009

AbstractIn Ergänzung zu bisherigen Beschreibungen von Pflanzenassoziationen aus der Mongolei (speziell Hilbig 1990), bei denen teilweise die Untergliederung in Subassoziationen noch nicht endgültig erfolgte, werden Subassoziationen von Assoziationen aus verschiedenen Pflanzenformationen von der Bergtaiga‐ bis zur Wüstenzone validiert, mit Typus‐Aufnahmen belegt und kurz standörtlich charakterisiert. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Wood anatomy and its implications on the taxonomy of Apollonias Nees (Lauraceae)
Authors: Loutfy M. H. A. 
Published: May 2009

AbstractIn the present work, wood anatomy of Apollonias barbujana (Lauraceae) was investigated by both Light Microscopy and Scanning Electron Microscopy and compared with six taxa of the Lauraceae representing the tribes Laureae and Perseeae. The investigated species included four of the endemic Macaronesian taxa of the Lauraceae (Laurus azorica, L. novocanariensis, Ocotea foetens and Persea indica) in addition to Laurus nobilis and Persea americana. The recorded characters were analyzed by the NTSYS‐PC program package, using the UPGMA clustering methods. The relationships between the studied taxa, expressed by average taxonomic distance (dissimilarity), were demonstrated as a phenogram. The study showed that Apollonias barbujana stood apart from the rest of the studied taxa of the Laureae and Perseeae by several unique features, predominantly uniseriate rays, multiseriate rays of 3–5 rows, striated fibers and/or sclereids with thick walls and many bordered pits, excessive tylose deposits, vessels with wide scalariform perforations with 6–12 bars and distinct bordered pits. More studies on this genus are needed. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
The effects of group living homes on older people with dementia: a comparison with traditional nursing home care
Authors: te Boekhorst Selma , Depla Marja F. I. A. , de Lange Jacomine , Pot Anne Margriet , Eefsting Jan A. 
Published: May 2009

AbstractObjectivesThe aim of this study was to investigate the effects of group living homes on quality of life and functioning of people with dementia.MethodsThe study had a quasi‐experimental design with a baseline measurement on admission and an effect measurement six months later. Participants were 67 residents in 19 group living homes and 97 residents in seven traditional nursing homes. DQOL and QUALIDEM measured quality of life, functional status was examined with MMSE, IDDD, RMBPC, NPI‐Q and RISE from RAI. Use of psychotropic drugs and physical restraints was also assessed. Linear and logistic regression analyses analyzed the data.ResultsAfter adjustment for differences in baseline characteristics, residents of group living homes needed less help with ADL and were more socially engaged. There were no differences in behavioral problems or cognitive status. Also after adjusting, two of the 12 quality of life subscales differed between the groups. Residents of group living homes had more sense of aesthetics and had more to do. While there were no differences in prescription of psychotropic drugs, residents of group living homes had less physical restraints.ConclusionsGroup living homes had some beneficial effects on its residents, but traditional nursing homes performed well as well. Possible study limitations included the baseline differences between the study groups and the use of different informants on T0 and T1. Future nursing home care may very well be a combination of the best group living care and traditional nursing home care have to offer. Copyright © 2009 John Wiley & Sons, Ltd.
Cytosolic accumulation of HPV16 E7 oligomers supports different transformation routes for the prototypic viral oncoprotein: The amyloid–cancer connection
Authors: Dantur Karina , Alonso Leonardo , Castaño Eduardo , Morelli Laura , Centeno‐Crowley Juan Manuel , Vighi Susana , de Prat‐Gay Gonzalo 
Published: May 2009

AbstractE7 is the major transforming activity in human papillomaviruses, a causal agent for cervical cancer. HPV16 E7 is a small protein with a natively unfolded domain for which dozens of specific cellular targets were described, and represents a prototypical oncoprotein among small DNA tumor viruses. The protein can form spherical oligomers with amyloid‐like properties and chaperone activity. Conformation specific antibodies locate endogenous oligomeric E7 species in the cytosol of 3 model cell lines, strongly co‐localizing with amyloid structures and dimeric E7 localizes to the nucleus. The cytosolic oligomeric E7 appear as the most abundant species in all cell systems tested. We show that nuclear E7 levels are replenished dynamically from the cytosolic pool and do not result from protein synthesis. Our results suggest that long‐term events related to de‐repression of E7 would cause accumulation of excess E7 into oligomeric species in the cytosol. These, together with the known target promiscuity of E7, may allow interactions with many of the non‐pRb dependent targets described. This hypothesis is further supported by the detection of E7 oligomers in the cytosol of cancerous cells from tissue biopsies. © 2009 UICC
Risk of thyroid cancer in survivors of childhood cancer: Results from the British Childhood Cancer Survivor Study
Authors: Taylor Aliki J. , Croft Adam P. , Palace Aimee M. , Winter David L. , Reulen Raoul C. , Stiller Charles A. , Stevens Michael C.G. , Hawkins Mike M. 
Published: May 2009

AbstractSecond primary neoplasms (SPNs) are a recognised late effect of treatment for childhood cancer. Thyroid SPNs can develop after exposure to low‐dose radiation, due to the radio‐sensitivity of the thyroid gland. The British Childhood Cancer Survivor Study (BCCSS) was set up to directly monitor the late effects of treatment, including risk of SPNs, in childhood cancer survivors and includes 17,980 5‐year survivors. We carried out a cohort analysis to determine the risk of thyroid SPNs in the BCCSS, and estimated risk using standardised incidence ratios (SIRs), relative risk (RR) using multivariate Poisson regression and cumulative incidence curves. There were 340,202 person years at risk subsequent to a 5‐year survival, median follow‐up 17.4 years per survivor. We identified 50 thyroid SPNs including 31 (62%) papillary carcinomas, 15 (30%) follicular carcinomas and 4 (8%) other types. 88% of thyroid SPNs developed after exposure to radiotherapy in or around the thyroid gland. SIR overall was 18.0 (95% confidence interval 13.4–23.8). Risk of thyroid cancer was highest after Hodgkin's disease: RR 3.3 (1.1–10.1) and Non Hodgkin's Lymphoma: RR 3.4 (1.1–10.7) relative to leukaemia (RR 1.0) (p < 0.001). Survivors treated with radiotherapy in childhood had a RR of 4.6 (1.4–15.1) relative to survivors not treated with radiotherapy (RR 1.0), p = 0003. In conclusion, the risk of thyroid cancer in childhood cancer survivors is relatively high in this cohort of childhood cancer survivors. These results will be of use in counselling survivors of childhood cancer exposed to radiation in or around the thyroid area. © 2009 UICC
Consumption of vegetables and fruit and the risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition
Authors: Büchner Frederike L. , Bueno‐de‐Mesquita H. Bas , Ros Martine M. , Kampman Ellen , Egevad Lars , Overvad Kim , Raaschou‐Nielsen Ole , Tjønneland Anne , Roswall Nina , Clavel‐Chapelon Francoise , Boutron‐Ruault Marie‐Christine , Touillaud Marina , Chang‐Claude Jenny , Kaaks Rudolf , Boeing Heiner , Weikert Steffen , Trichopoulou Antonia , Lagiou Pagona , Trichopoulos Dimitrios , Palli Domenico , Sieri Sabina , Vineis Paolo , Tumino Rosario , Panico Salvatore , Vrieling Alina , Peeters Petra H.M. , van Gils Carla H. , Lund Eiliv , Gram Inger T. , Engeset Dagrun , Martinez Carmen , Gonzalez Carlos A. , Larrañaga Nerea , Ardanaz Eva , Navarro Carmen , Rodríguez Laudina , Manjer Jonas , Ehrnström Roy A. , Hallmans Goran , Ljungberg Borje , Allen Naomi E. , Roddam Andrew W. , Bingham Sheila , Khaw Kay‐Tee , Slimani Nadia , Boffetta Paolo , Jenab Mazda , Mouw Traci , Michaud Dominique S. , Kiemeney Lambertus A.L.M. , Riboli Elio 
Published: May 2009

AbstractPrevious epidemiologic studies found inconsistent associations between vegetables and fruit consumption and the risk of bladder cancer. We therefore investigated the association between vegetable and fruit consumption and the risk of bladder cancer among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Data on food consumption and complete follow‐up for cancer occurrence was available for a total of 478,533 participants, who were recruited in 10 European countries. Estimates of rate ratios were obtained by Cox proportional hazard models, stratified by age at recruitment, gender and study centre, and adjusted for total energy intake, smoking status, duration of smoking and lifetime intensity of smoking. A calibration study in a subsample was used to control for dietary measurement errors. After a mean follow‐up of 8.7 years, 1015 participants were newly diagnosed with bladder cancer. Increments of 100 g/day in fruit and vegetable consumption combined did not affect bladder cancer risk (i.e., calibrated HR = 0.98; 95%CI: 0.95–1.01). Borderline statistically significant lower bladder cancer risks were found among never smokers with increased consumption of fruit and vegetables combined (HR = 0.94 95%CI: 0.87–1.00 with increments of 100 g/day; calibrated HR = 0.92 95%CI 0.79–1.06) and increased consumption of apples and pears (hard fruit; calibrated HR = 0.90 95%CI: 0.82–0.98 with increments of 25 g/day). For none of the associations a statistically significant interaction with smoking status was found. Our findings do not support an effect of fruit and vegetable consumption, combined or separately, on bladder cancer risk. © 2009 UICC
Identification of the major TG4 cross‐linking sites in the androgen‐dependent SVS I exclusively expressed in mouse seminal vesicle
Authors: Tseng Huan‐Chin , Lin Han‐Jia , Tang Jyh‐Bing , Gandhi P.S. Sudhakar , Chang Wei‐Chao , Chen Yee‐Hsiung 
Published: May 2009

AbstractSVS I was exclusively expressed in seminal vesicle in which the protein was immunolocalized primarily to the luminal epithelium of mucosal folds. The developmental profile of its mRNA expression was shown to be androgen‐dependent, manifesting a positive correlation with the animal's maturation. There are 43 glutamine and 43 lysine residues in one molecule of SVS I, which is one of the seven major monomer proteins tentatively assigned on reducing SDS–PAGE during the resolution of mouse seminal vesicle secretion. Based on the fact that SVS I‐deduced protein sequence consists of 796 amino acid residues, we produced 7 recombinant polypeptide fragments including residues 1–78/F1, residues 79–259/F2, residues 260–405/F3, residues 406–500/F4, residues 501–650/F5, residues 651–715/F6, and residues 716–796/F7, and measured the covalent incorporation of 5‐(biotinamido)pentylamine (BPNH2) or biotin‐TVQQEL (A25 peptide) to each of F1‐to‐F7 by type 4 transglutaminase (TG4) from the coagulating gland secretion. F2 was active to a greater extent than the other fragments during the BPNH2‐glutamine incorporation, and a relatively low extent of A25‐lysine cross link was observed with all of the seven fragments. The MS analysis of BPNH2‐F2 conjugate identified Q232 and Q254 as the two major TG4 cross‐linking sites. This was substantiated by the result that much less BPNH2 was cross‐linked to any one of the three F2 mutants, including Q232G and Q254G obtained from single‐site mutation, and Q232G/Q254G from double‐site mutation. J. Cell. Biochem. 107: 899–907, 2009. © 2009 Wiley‐Liss, Inc.
Aberrant trafficking of human melanocortin 1 receptor variants associated with red hair and skin cancer: Steady‐state retention of mutant forms in the proximal golgi
Authors: Sánchez‐Laorden Berta L. , Herraiz Cecilia , Valencia Julio C. , Hearing Vincent J. , Jiménez‐Cervantes Celia , García‐Borrón José C. 
Published: May 2009

AbstractThe melanocortin 1 receptor (MC1R), a Gs protein‐coupled receptor (GPCR) expressed in melanocytes, is a major determinant of skin pigmentation and phototype. MC1R activation stimulates melanogenesis and increases the ratio of black, strongly photoprotective eumelanins to reddish, poorly photoprotective pheomelanins. Several MC1R alleles are associated with red hair, fair skin, increased sensitivity to ultraviolet radiation (the RHC phenotype) and increased skin cancer risk. Three highly penetrant RHC variants, R151C, R160W, and D294H are loss‐of‐function MC1R mutants with altered cell surface expression. In this study, we show that forward trafficking was normal for D294H. Conversely, export traffic was impaired for R151C, which accumulated in the endoplasmic reticulum (ER), and for R160W, which was enriched in the cis‐Golgi. This is the first report of steady‐state retention in a post‐ER secretory compartment of a GPCR mutant found in the human population. Residues R151 and R160 are located in the MC1R second intracellular loop (il2). Two other mutations in il2, T157A preventing T157 phosphorylation and R162P disrupting a 160RARR163 motif, also caused intracellular retention. Moreover, T157 was phosphorylated in wild‐type MC1R and a T157D mutation mimicking constitutive phosphorylation allowed normal traffic, and rescued the retention phenotype of R160W and R162P. Therefore, MC1R export is likely regulated by T157 phosphorylation and the 160RARR163 arginine‐based motif functions as an ER retrieval signal. These elements are conserved in mammalian MC1Rs and in all five types of human melanocortin receptors. Thus, members of this GPCR subfamily might share common mechanisms for regulation of plasma membrane expression. J. Cell. Physiol. 220: 640–654, 2009. © 2009 Wiley‐Liss, Inc.
Pathogenic stimulation of intestinal stem cell response in drosophila
Authors: Chatterjee Madhurima , Ip Y. Tony 
Published: May 2009

AbstractStem cell‐mediated tissue repair is a promising approach for many diseases. Mammalian intestine is an actively regenerating tissue such that epithelial cells are constantly shedding and underlying precursor cells are constantly replenishing the loss of cells. An imbalance of these processes will lead to intestinal diseases including inflammation and cancer. Mammalian intestinal stem cells (ISCs) are located in bases of crypts but at least two groups of cells have been cited as stem cells. Moreover, precursor cells in the transit amplifying zone can also proliferate. The involvement of multiple cell types makes it more difficult to examine tissue damage response in mammalian intestine. In adult Drosophila midgut, the ISCs are the only cells that can go through mitosis. By feeding pathogenic bacteria and stress inducing chemicals to adult flies, we demonstrate that Drosophila ISCs in the midgut can respond by increasing their division. The resulting enteroblasts, precursor cells for enterocytes and enteroendocrine cells, also differentiate faster to become cells resembling enterocyte lineage. These results are consistent with the idea that Drosophila midgut stem cells can respond to tissue damage induced by pathogens and initiate tissue repair. This system should allow molecular and genetic analyses of stem cell‐mediated tissue repair. J. Cell. Physiol. 220: 664–671, 2009. © 2009 Wiley‐Liss, Inc.
Role of LOX‐1 in monocyte adhesion‐triggered redox, Akt/eNOS and Ca2+ signaling pathways in endothelial cells
Authors: Sakamoto Nobuo , Ishibashi Toshiyuki , Sugimoto Koichi , Sawamura Tatsuya , Sakamoto Takayuki , Inoue Nobutaka , Saitoh Shu‐ichi , Kamioka Masashi , Uekita Hironori , Ohkawara Hiroshi , Suzuki Koji , Teramoto Tamio , Maruyama Yukio , Takeishi Yasuchika 
Published: May 2009

AbstractThis study was conducted to examine the role of lectin‐like oxidized low‐density lipoprotein receptor‐1 (LOX‐1) in monocyte adhesion‐induced redox‐sensitive, Akt/eNOS and Ca2+ signaling pathways in endothelial cells (ECs). LOX‐1 was blocked by an antibody‐neutralizing LOX‐1 TS92 or small interfering RNA. In cultured human aortic ECs, monocyte adhesion activated Rac1 and p47phox, and increased NADPH oxidase activity and reactive oxygen species (ROS) generation within 30 min and NF‐κB phosphorylation within 1 h, resulting in redox‐sensitive gene expression. Akt and eNOS phosphorylation was induced 15 min after adding monocytes and returned to control level after 30 min, whereas NO production was not altered by monocyte adhesion. Blockade of LOX‐1 blunted the monocyte adhesion‐triggered redox‐sensitive signaling pathway and Akt/eNOS phosphorylation in ECs. Both endothelial intracellular Ca2+ mobilization and Ca2+ influx caused by monocyte attachment were markedly attenuated by pretreatment of ECs with TS92. This suggests that LOX‐1 is involved in redox‐sensitive, Akt/eNOS and Ca2+ signaling pathways in monocyte adhesion to ECs independent of oxidized low‐density lipoprotein (ox‐LDL). Furthermore, blockade of Ca2+ inhibited monocyte adhesion‐triggered Rac1 and p47phox activation and ROS generation in ECs, whereas Ca2+ signaling was suppressed by blockade of NADPH oxidase and ROS generation. Finally, TS92 blocked the monocyte adhesion to ECs stimulated with or without tumor necrosis factor‐α or ox‐LDL. We provide evidence that LOX‐1 plays a role in redox‐sensitive, Akt/eNOS and Ca2+ signaling pathways in monocyte adhesion to ECs independent of the ox‐LDL–LOX‐1 axis. J. Cell. Physiol. 220: 706–715, 2009. © 2009 Wiley‐Liss, Inc.