bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the regional politics of ‘sustainability’: making up sustainable communities in the South‐East of England
Authors: Cochrane Allan 
Published: October 2010

AbstractThis paper sets to explore and clarify the nature of the politics associated with the institutional shift from government to governance, in the context of the rise of sustainability and sustainable communities as governance discourses. After critically considering the extent to which this represents a move to some sort of post‐political settlement, it turns to reflect on the notion of assemblage as a means of interpreting emergent forms of politics and governance and exploring the ways in which different priorities may be negotiated in practice. It highlights the processes by which new political realities are assembled around particular concerns without necessarily ever being fully integrated into some overarching unified set of understandings, and it highlights continued tensions and divisions around sustainability and its implications, which undermine attempts to build a governing (or post‐political) consensus. These issues are informed by a review of some aspects of the ‘sustainable communities plan’ and its implementation, with a particular focus on the South‐East of England. Copyright © 2010 John Wiley & Sons, Ltd and ERP Environment.
Bridged fac‐Tricarbonylrhenium(I)–Biscarbene Complexes: Synthesis, Characterization, and Molecular Dynamics
Authors: Hiltner Oliver , Boch Florian J. , Brewitz Lennart , Härter Peter , Drees Markus , Herdtweck Eberhardt , Herrmann Wolfgang A. , Kühn Fritz E. 
Published: October 2010

AbstractSix new biscarbene complexes of the type fac‐[(CO)3ReIBr(L)], where L represents a chelating bis(N‐heterocyclic carbene) ligand consisting of two alkylene‐bridged (R′), N‐substituted (R) imidazoline moieties (1,1′‐diR‐3,3′‐R′‐diimidazoline‐2,2′‐diylidene), were synthesized. Spectroscopic methods and X‐ray crystallography were employed to characterize the complexes in solution and the solid state. The observed dynamic behavior of the complexes in solution was examined in more detail by temperature‐dependent 1H NMR experiments and further analyzed by DFT calculations.
Room‐Temperature Synthesis of the Highly Polar Cluster Compound Sn[SnCl][W3Cl13]
Authors: Ahmed Ejaz , Groh Matthias , Ruck Michael 
Published: October 2010

AbstractA new synthetic strategy is employed to synthesize a tungsten trinuclear cluster compound with an ionic liquid (IL) as the reaction medium. Dark brown block‐shaped crystals of Sn[SnCl][W3Cl13] were obtained at room temperature by reacting tin and WCl6 in Lewis acidic ionic liquid [BMIM]Cl/AlCl3 ([BMIM]+ = 1‐butyl‐3‐methylimidazolium). Compound Sn[SnCl][W3Cl13] crystallizes in the polar hexagonal space group P63 with cell parameters a = 959.8(1) and c = 1190.3(2) pm. The crystallographic point group of the [W3(μ3‐Cl)(μ‐Cl)3Cl9]3– cluster anions is C3, but C3v pseudosymmetry is observed within twice the standard deviation of the bond lengths. The W–W bond length is 272.18(6) pm. The tin(II) cations, which are in trigonal pyramidal and in distorted trigonal‐antiprismatic coordination spheres that comprise chloride ions, connect the clusters into layers that are stacked according to the 63 screw axis. One of the chloride ions is bound only to a single tin cation resulting in a [SnIICl]+ group with a Sn–Cl bond length of 236.1(5) pm. The pronounced polarity of the crystal structure means that its diffraction pattern exhibits huge deviations from Friedel's law. Most remarkable is that the intensity (Fc2) of reflection 004 is 175 % of the intensity of the 00$\bar {4}$ reflection.
Convenient Synthesis of 3‐Cinnamoyl‐2‐styrylchromones: Reinvestigation of the Baker–Venkataraman Rearrangement
Authors: Königs Pia , Neumann Olivia , Kataeva Olga , Schnakenburg Gregor , Waldvogel Siegfried R. 
Published: October 2010

AbstractAn efficient and straightforward, one‐pot sequence gives access to highly functionalized 3‐cinnamoyl‐2‐styrylchromones in excellent yields. The low solubility of the target molecules allows convenient isolation. The formation of an α,α‐dicinnamoylated acetophenone, as a consequence of a two‐fold Baker–Venkataraman sequence, has to be anticipated.
Batch and continuous packed column studies of chromium (III) biosorption by olive stone
Authors: Blázquez G. , Calero M. , Hernáinz F. , Tenorio G. , Martín‐Lara M.A. 
Published: October 2010

AbstractIn this work, the biosorption properties of olive stone for removal of trivalent chromium were investigated in batch and continuous systems. First, batch isotherm studies were carried out on laboratory scale to evaluate the Cr (III) biosorption capacity of olive stone. Equilibrium uptake of Cr (III) ions from aqueous solutions by olive stone was fitted to Langmuir, Freundlich, and Redlich‐Peterson isotherms. These studies showed that the adsorption data can be described by these isotherms and the maximum sorption capacity of olive stone for Cr (III) by Langmuir model was 5.19 mg g−1 at 25°C and at pH 4. Then, continuous packed bed column configuration was examined as a function of inlet chromium concentration and bed height. Also, the well‐established design model, Bed Depth Service Time (BDST) model was used to analyze the continuous sorption data. Finally, the continuous packed bed column data were compared with those of the batch system. © 2010 American Institute of Chemical Engineers Environ Prog, 2010
The association between length of benzodiazepine use and sleep quality in older population
Authors: Béland Sarah‐Gabrielle , Préville Michel , Dubois Marie‐France , Lorrain Dominique , Voyer Philippe , Bossé Cindy , Grenier Sebastien , Moride Yola ,   Scientific Committee of the ESA Study
Published: October 2010

AbstractBackgroundSleep disturbances are frequently reported in the older adult population and benzodiazepines are the drugs most often prescribed to treat these problems. Nearly 25% of the older adult population uses these drugs and 83% of benzodiazepine users report sleep problems. Although the Collège des Médecins du Québec suggests a maximum length of use of 3 months, according to most studies the mean length of benzodiazepine use is longer. The goal of this study was to document the association between length of benzodiazepine use and sleep quality as reported by adults 65 years older and over.MethodsData used in this study came from the Seniors' Health Survey (ESA) conducted in a representative sample of the community‐dwelling older population in Quebec, Canada. Inclusion criteria included the ability to speak and understand French. Data were analyzed using a structural equation modeling strategy.ResultsLong‐term benzodiazepine users were more likely to report poor sleep quality. Sleep quality of initial probable problematic sleepers tended to increase over 1 year but sleep quality in benzodiazepines users increased less rapidly than in non‐users. Also, women were more likely to report using benzodiazepines and having poorer sleep quality.ConclusionLongitudinal studies using incident cases of benzodiazepine use should be conducted to better determine the causal relationship between sleep quality and benzodiazepine use in the older population. Copyright © 2010 John Wiley & Sons, Ltd.
Microwave‐Assisted Synthesis of Novel 2,4‐Dihydro‐5‐[4‐(trifluoromethyl)phenyl]‐3H‐1,2,4‐triazol‐3‐ones and Potentiometric Determination of Their pKa in Nonaqueous Solvents
Authors: Özil Musa , İslamoğlu Fatih , Menteşe Emre , Kahveci Bahittin 
Published: October 2010

AbstractThe novel 4‐amino‐ or 4‐aryl‐substituted 2,4‐dihydro‐5‐[(4‐trifluoromethyl)phenyl]‐3H‐1,2,4‐triazol‐3‐ones 3a–3g were synthesized by reaction of N‐(ethoxycarbonyl)‐4‐(trifluoromethyl)benzenehydrazonic acid ethyl ester (2) and primary amines or hydrazine by microwave irradiation. Compounds 3a–3g were potentiometrically titrated with tetrabutylammonium hydroxide (Bu4NOH) in four nonaqueous solvents, i.e., iPrOH, tBuOH, MeCN, and N,N‐dimethylformamide (DMF). Also half‐neutralization potential values and the corresponding pKa values were determined in all cases.
Pentacyclic Triterpenoid Saponins from Silene viscidula
Authors: Xu Wei , Wu Jia‐Mei , Zhu Zheng , Sha Yi , Fang Jin , Li Yu‐Shan 
Published: October 2010

AbstractThree new pentacyclic triterpenoid saponins, viscidulosides A and B (1 and 2, resp.), and silenoviscoside D (3), were isolated from the roots of Silene viscidula, together with two known saponins, sinocrassulosides VIII and IX (4 and 5, resp.). Their structures were elucidated by spectroscopic data and chemical methods. Compounds 1/2 and 4/5 were two inseparable mixtures, which are glycosides of quillaic acid whose fucose residue is acylated by (E)‐ or (Z)‐4‐methoxycinnamic acid.
A New Monoterpene–Coumarin and a New Monoterpene–Chromone from Gerbera delavayi
Authors: Liu Shuang‐Zhu , Feng Jia‐Quan , Wu Jian , Zhao Wei‐Min 
Published: October 2010

AbstractPhytochemical investigation of the whole plants of Gerbera delavayi (Compositae) led to the isolation and identification of 15 compounds, including the new monoterpene–coumarin 1 and the new monoterpene–chromone 2. Their structures were determined on the basis of spectroscopic analyses including 1D‐ and 2D‐NMR experiments and comparison with spectroscopic data of the literature.
Three‐Component Reaction of an Isocyanide and a Dialkyl Acetylenedicarboxylate with a Phenacyl Halide in the Presence of Water: An Efficient Method for the One‐Pot Synthesis of γ‐Iminolactone Derivatives
Authors: Ramazani Ali , Rezaei Aram , Mahyari Amir Tofangchi , Rouhani Morteza , Khoobi Mehdi 
Published: October 2010

AbstractThe zwitterion, formed from the reaction of an alkyl isocyanide and a dialkyl acetylenedicarboxylate, reacts with phenacyl halides in H2O to produce γ‐iminolactone derivatives in high yields. H2O helps to avoid the use of highly toxic and environmentally unfavorable solvents for this conversion.
Synthesis and Redox Behavior of Novel 9,10‐Diphenylphenanthrenes
Authors: Schreivogel Alina , Sieger Monika , Baro Angelika , Laschat Sabine 
Published: October 2010

AbstractThe synthesis and electrochemical investigations of 9,10‐diphenylphenanthrene 2a and its derivatives 2b–2e are reported. The cyclic voltammetry of derivatives 2a–2c and 2e in different solvent/Bu4NPF6 electrolyte systems reveals that the redox properties are dependent on solvent, temperature, and sweep rate. The oxidation of 9,10‐diphenylphenanthrene 2a occurred as an irreversible process, while two fully reversible oxidation waves were observed for dimethoxy derivative 2c. The room‐temperature oxidation of brominated compound 2b is reversible, whereas AcO‐substituted phenanthrene 2e displayed a reversible oxidation peak only at low temperature. Furthermore, the electronic nature of the substituent affects the oxidation potentials. In the CH2Cl2‐based electrolyte system, the first oxidation potentials increase in the order 2c<2e<2b.
Chemical and Genetic Study of Ligularia anoleuca and L. veitchiana in Yunnan and Sichuan Provinces of China
Authors: Nagano Hajime , Kanda Midori , Yamada Hiroka , Hanai Ryo , Gong Xun , Kuroda Chiaki 
Published: October 2010

AbstractChemical and genetic study of Ligularia anoleuca and L. veitchiana, which belong to section Ligularia, series Speciosae, was carried out. From L. anoleuca samples, collected in Yunnan and Sichuan Provinces of China, a new compound, furanoeremophil‐1(10)‐en‐6α‐ol, was isolated together with known 6β‐{[2‐(hydroxymethyl)prop‐2‐enoyl]oxy}furanoeremophil‐1(10)‐ene and 1β,10β‐epoxy‐6β‐{[2‐(hydroxymethyl)prop‐2‐enoyl]oxy}furanoeremophilane. From L. veitchiana samples, collected in Yunnan Province, euparin, 2‐isopropenyl‐5,6‐dimethoxybenzofuran, and 6‐hydroxy‐3β‐methoxytrementone were isolated. DNA Sequencing of the internal transcribed spacers of the ribosomal RNA gene showed that the two species are not particularly close despite morphological similarities, in agreement with the chemical results.
Radiolabeled cetuximab: Dose optimization for epidermal growth factor receptor imaging in a head‐and‐neck squamous cell carcinoma model
Authors: Hoeben Bianca A.W. , Molkenboer‐Kuenen Janneke D.M. , Oyen Wim J.G. , Peeters Wenny J.M. , Kaanders Johannes H.A.M. , Bussink Johan , Boerman Otto C. 
Published: October 2010

AbstractNoninvasive imaging of the epidermal growth factor receptor (EGFR) in head‐and‐neck squamous cell carcinoma could be of value to select patients for EGFR‐targeted therapy. We assessed dose optimization of 111Indium‐DTPA‐cetuximab (111In‐cetuximab) for EGFR imaging in a head‐and‐neck squamous cell carcinoma xenograft model. 111In‐cetuximab slowly internalized into FaDu cells in vitro, amounting to 1.0 × 104 molecules cetuximab per cell after 24 hr (15.8% of added activity). In nude mice with subcutaneous FaDu xenograft tumors, a protein dose escalation study with 111In‐cetuximab showed highest specific accumulation in tumors at protein doses between 1 and 30 μg per mouse (mean tumor uptake 33.1 ± 3.1%ID/g, 3 days postinjection (p.i.)). The biodistribution of 111In‐cetuximab and 125I‐cetuximab was determined at 1, 3 and 7 days p.i. at optimal protein dose. Tumor uptake was favorable for 111In‐cetuximab compared to 125I‐cetuximab. With pixel‐by‐pixel analysis, good correlations were found between intratumoral distribution of 111In‐cetuximab as determined by autoradiography and EGFR expression in the same tumor sections as determined immunohistochemically (mean r = 0.74 ± 0.14; all correlations p < 0.0001). Micro Single Photon Emission Computed Tomography (MicroSPECT) scans clearly visualized FaDu tumors from 1 day p.i. onward and tumor‐to‐background contrast increased until 7 days p.i. (tumor‐to‐liver ratios 0.58 ± 0.24, 3.42 ± 0.66, 8.99 ± 4.66 and 16.33 ± 11.56, at day 0, day 1, day 3 and day 7 p.i., respectively). Our study suggests that, at optimal cetuximab imaging dose, 111In‐cetuximab can be used for visualization of EGFR expression in head‐and‐neck squamous cell carcinoma using SPECT.
Anticancer drugs that target metabolism: Is dichloroacetate the new paradigm?
Authors: Papandreou Ioanna , Goliasova Tereza , Denko Nicholas C. 
Published: October 2010

AbstractRecent findings in the fields of oncogenic regulation of metabolism, mitochondrial function and macromolecular synthesis have brought tumor metabolism and the Warburg effect back into the scientific limelight. A number of metabolic pathways that seem to be important for tumor growth are being touted as novel targets for anticancer drug development. One of the candidates in this class of drugs being investigated is dichloroacetate (DCA), a molecule used for over 25 years in the treatment of children with inborn errors in mitochondrial function. This pyruvate mimetic compound stimulates mitochondrial function by inhibiting the family of regulatory pyruvate dehydrogenase kinases (PDK1–4). The stimulation of mitochondrial function, at the expense of glycolysis, reverses the Warburg effect and is thought to block the growth advantage of highly glycolytic tumors. Interestingly, some of the recent in vitro findings have shown very modest “antitumor cell activity” of DCA when cells are treated in a dish. However, several studies have reported “antitumor activity” in model tumors. This apparent paradox raises the question, how do we evaluate cancer drugs designed to target tumor metabolism? Traditional approaches in cancer drug development have used in vitro assays as a first pass to evaluate potential lead compounds. The fact that DCA has better in vivo activity than in vitro activity suggests that there are unique aspects of solid tumor growth and metabolism that are difficult to recapitulate in vitro and may be important in determining the effectiveness of this class of drugs.
Cancer registration and healthcare access in West Bank, Palestine: A GIS analysis of childhood cancer, 1998–2007
Authors: Bailony M. Rami , Hararah Mohammad K. , Salhab Abdel Razzaq , Ghannam Ibrahim , Abdeen Ziad , Ghannam Jess 
Published: October 2010

AbstractIn low and middle income countries (LMIC), high‐quality disease registration is difficult to achieve in the setting of inadequate healthcare infrastructure and political or economical instability. In this article, we explore the potential of geographic information systems (GIS) to add value to the understanding of childhood cancer patterns in the West Bank, despite a variety of obstacles to disease registration. All incidence cases of childhood cancers (under the age 15) from 1998 to 2007 were collected from the West Bank Cancer Registry. Temporal, spatial and space–time analyses were performed using the SatScan software developed by Martin Kulldorff and the National Cancer Institute (NCI). The analyses were categorized into the following groups: all childhood cancer, leukemias, acute lymphocytic leukemia, lymphomas, brain and central nervous system (CNS) cancers and remaining cancers (excluding leukemia, lymphoma and CNS tumors). The temporal analysis revealed that cancer registration was more complete from 1998 to 2000 (p = 0.0162), and that leukemia registration was severely deficient from 2003 to 2005 (p = 0.0012). The spatial analysis showed a concentration of cancer in metropolitan districts where referral hospitals are based. Under registration was detected in the northern districts of Jenin and Tulkarm (RR = 0.59, p = 0.0059), more prominent from 2002 to 2005 (RR = 0.33, p = 0.0006). The analysis for high rates found a cluster of lymphoma in town of Dura and its surrounding agricultural villages (RR = 4.10, p = 0.0023). Our study reveals that the application of GIS tools to registry data in LMIC can help to identify geographical patterns in cancer registration and healthcare accessibility, generating priorities for future health research and policy in resource‐limited areas.
Increased Temperature Due to Global Warming Alters the Respiratory Potential in Aquatic Organisms from an Oligotrophic Lake
Authors: Simčič Tatjana , Germ Mateja 
Published: October 2010

AbstractThe influence of elevated temperature was studied on the respiratory potential of a microplankton community, two macrophytes species (Myriophyllum spicatum and Chara aspera), and sediments, all from an oligotrophic lake, in order to estimate their susceptibility to temperature change. Samples collected in winter, spring, summer and autumn were incubated at three different temperatures. The respiratory potential, measured as electron transport system (ETS) activity at a standard temperature of 20 °C was, in average, greater at higher incubation temperatures for 117% in microplankton and for 30% in sediments, indicating that elevated temperature influenced the respiratory capacity of the microbial communities for mineralization of organic matter through respiration. The large increases of respiratory potential in winter microplankton community (for 184% at the highest incubation temperature compared to the temperatures of the multiyear period) and spring microplankton community (190%), and in spring sediment (64%) reveal that those communities are most susceptible to elevated temperatures during the coldest period of a year and at the beginning of lake warming. The respiratory activity of Myriophyllum spicatum was independent of incubation temperature, indicating its wide physiological tolerance. The lower respiratory potential at higher temperatures in Chara aspera optimized the use of energy in plants. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Publications of BRIC‐ and Outreach Countries in International Journals on Limnology
Authors: Walz Norbert 
Published: October 2010

AbstractPollution, overexploitation and climate warming endanger the freshwater ecosystems in many regions, particularly in developing countries. This publication asks if at least the BRIC (Brazil, Russia, India and China) group and the Outreach countries (in addition South Africa and Mexico), have the scientific capacity in limnology to mitigate this development. For this reason the scientific output was analyzed between 1999 and 2007. With a share of 5.0% of all limnological papers in 2007 world wide the P.R. China (Peoples Republic of China) produced the largest numbers of publications, followed by Brazil and Mexico. For comparison, this year Germany's share was 5.8% and the USA had the highest share with 33.9%. The growth rate was also highest for the P. R. China and Brazil. Based on the journal impact factors, China's quality of papers was best followed by South Africa and Russia. Brazil was strong in fish biology, whereas China published the most papers in all other disciplines. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Effects of gallic acid on brain lipid peroxide and lipid metabolism in streptozotocin‐induced diabetic Wistar rats
Authors: Mainzen Prince P. Stanely , Kumar M. R. , Selvakumari C. J. 
Published: October 2010

AbstractThis study evaluated the protective effects of gallic acid on brain lipid peroxidation products, antioxidant system, and lipids in streptozotocin‐induced type II diabetes mellitus. Streptozotocin‐induced diabetic rats showed a significant increase in the levels of blood glucose, brain lipid peroxidation products, and lipids and a significant decrease in the activities of brain enzymic antioxidants. Oral treatment with gallic acid (10 mg and 20 mg/kg) for 21 days significantly decreased the levels of blood glucose, brain lipid peroxidation products, and lipids and significantly increased the activities of brain enzymic antioxidants in diabetic rats. Histopathology of brain confirmed the protective effects of gallic acid. Furthermore, in vitro study revealed the free radical scavenging action of gallic acid. Thus, our study shows the beneficial effects of gallic acid on brain metabolism in streptozotocin‐induced type II diabetic rats. A diet containing gallic acid may be beneficial to type II diabetic patients. © 2010 Wiley Periodicals, Inc. J Biochem Mol Toxicol 25:101–107, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.20365
Effect of histidine on autotaxin activity in experimentally induced liver fibrosis
Authors: El‐Batch Manal , Ibrahim Wafaa , Said Soha 
Published: October 2010

AbstractThe aim of this study was to explain whether serum autotaxin (ATX) activity might be a target for regulation of liver fibrosis and to evaluate the hepatoprotective and antifibrotic effects of histidine in thioacetamide (TAA)–induced liver fibrosis in rats. This study was carried out on 100 Wistar Albino rats, classified into five groups, each containing 20 rats: Group I (control group), Group II: rats were given histidine intraperitoneally, Group III: rats were injected intraperitoneally with TAA, Group IV: rats were injected with L‐histidine together with TAA, and Group V: rats were injected with TAA for 1 month then treated with intraperitoneal injection of L‐histidine for another month. At the end of experiment, blood and liver were collected for determination of some liver enzymes, plasma total antioxidant capacity (TAC), serum ATX activity, and liver tissue hydroxyproline. Thioacetamide treatment caused significant increases in liver enzymes, ATX activities, and liver hydroxyproline, but a significant decrease in plasma's TAC. Upon treatment with histidine, a significant decrease in liver enzymes, ATX activities, and liver hydroxyproline was observed with a significant increase in plasma TAC in Group IV and a significant decrease in Group V. Histidine as an antioxidant has a protective effect on TAA‐induced liver fibrosis; it is beneficial in rats not only by inhibition of collagen synthesis and increasing TAC but also by inhibition of ATX activities thus reducing its capacity to produce lysophosphatidic acid, which has a role in liver fibrosis. © 2010 Wiley Periodicals, Inc. J Biochem Mol Toxicol 25:143–150, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.20370