bluuebunny/crossref_metadata_2025_split huggingface dataset:
Earliest Triassic microbialites in Çürük Dag, southern Turkey: composition, sequences and controls on formation
Authors: KERSHAW STEVE , CRASQUIN SYLVIE , FOREL MARIE‐BÉATRICE , RANDON CARINE , COLLIN PIERRE‐YVES , KOSUN ERDAL , RICHOZ SYLVAIN , BAUD AYMON 
Published: August 2010

AbstractThe Permian–Triassic Boundary sequence at Çürük Dag, near Antalya, Turkey, begins with a major erosion surface interpreted as being the Late Permian lowstand, on which lies ca 0·4 m of grainstone/packstone composed of ooids, peloids and bioclasts. Most ooids are superficial coats on fragments of calcite crystals presumed to be eroded from crystal fans which are no longer present. The erosion surface is smooth and shows no evidence of dissolution; the grainstone/packstone contains intraclasts of the underlying wackestone, proving erosion. Next are 15 m of microbialite comprised of interbedded stromatolites, thrombolites, plus beds of planar limestones with small‐scale erosion. The latter comprise a complex interlayering of stromatolitic, thrombolitic and peloidal fabrics and precipitated crystal fans, which form a hybrid of microbialite and inorganic carbonate, together with bioclastic debris and micrite. The Çürük Dag microbialite sequence is repetitious; the lower part is more complex, with abundant stromatolites and hybrid microbialites. Some of the stromatolites are themselves hybrids composed of peloids and crystal fans. In the upper part of the sequence stromatolites are missing and the rock is composed mostly of recrystallized thrombolites that develop upwards from tabular to domal form. The domes form directly below small breaks in microbialite growth where very thin shelly micrites and grainstones/packstones are deposited. Repetition of facies may be controlled by sea‐level change; a deepening‐up model is consistent with the evidence. Stromatolites (with abundant crystal fans) dominate in shallower water, deepening through hybrid microbialite and interlayered sediments to thrombolite, probably no more than a few tens of metres deep, followed by breaks and renewal of microbialite growth. An interpretation of open marine fully oxygenated waters for microbialite growth is consistent with ongoing parallel work that has identified Bairdioid ostracods in the microbialite, a group known to be open marine. However, other researchers have proposed low oxygen conditions for Permian–Triassic boundary facies globally, so work continues to confirm whether the Çürük Dag microbialite grew in dysoxic or normally oxygenated conditions. The principal stimulus for post‐extinction microbialites is likely to be carbonate supersaturation of the oceans. The microbialite sequence is overlain by a further 25 m of grainstone/packstone (without microbialite), followed by Early Triassic shales. Overall, microbialites form a thin aggradational sequence during an overall relative sea‐level rise, consistent with global eustatic rise following the Late Permian lowstand.
Multiple progressive piloleiomyomas in a ferret (Mustela putorius furo): a case report
Authors: Mialot Martine , Prata Daniela , Girard‐Luc Anne , Rakotovao Farasoa , Cuveillier Jean‐François , Bernex Florence 
Published: August 2010

AbstractA 2.5‐year‐old ovariectomized female ferret developed multiple progressive linear and raised nodules on the skin. The first lesions occurred on the tail, which was then amputated. Over the following 3 years, additional lesions appeared in the vicinity of the scar and then further rostrally on the flanks and thorax. Histological and immunohistochemical investigation led to a diagnosis of multiple piloleiomyomas. The unique characteristics of this ferret disease are described and compared with those of multiple piloleiomyomas in humans and with those of other cutaneous smooth muscle cell tumours reported in the veterinary literature.
Ineligibility for renal transplantation: prevalence, causes and survival in a consecutive cohort of 445 patients
Authors: Kianda Mireille N. , Wissing Karl M. , Broeders Nulifer E. , Lemy Anne , Ghisdal Lidia , Hoang Anh D. , Mikhalski Dimitri , Donckier Vincent , Vereerstraeten Pierre , Abramowicz Daniel 
Published: August 2010

Kianda MN, Wissing KM, Broeders NE, Lemy A, Ghisdal L, Hoang AD, Mikhalski D, Donckier V, Vereerstraeten P, Abramowicz D. Ineligibility for renal transplantation: prevalence, causes and survival in a consecutive cohort of 445 patients. Clin Transplant 2011: 25: 576–583. © 2010 John Wiley & Sons A/S.Abstract:  Little is known about the proportion of renal transplant candidates who are considered ineligible by the transplant center, the reasons of their ineligibility and their survival during dialysis. In this retrospective, single‐center study of 445 adult patients referred between 2001 and 2006, 36 (8%) were deemed ineligible for medical contraindications. The leading reason was cardiovascular (CV) (75%), specifically aorto‐iliac, and/or limb vessels atheromatosis or calcifications; ischemic heart disease; or a combination thereof. Nine patients had other contraindications that were absolute for three of them; six patients displayed a combination of relative contraindications. When compared to eligible patients (N = 409), those ineligible were significantly older (60 yr vs. 48), more often diabetics (50% vs. 15%), obese (39% vs. 17%) suffering from coronary artery disease (53% vs. 11%) and peripheral arterial disease (86% vs. 11%). Their primary nephropathy was more often diabetic and/or hypertensive/nephroangiosclerosis (61% vs. 23%), and their median dialysis vintage prior to evaluation was longer (29 months vs. 10, p < 0.0001). The actuarial survival of ineligible patients was significantly lower than that of eligible patients (at five yr: 53% vs. 88%). Adequate control of CV risk factors before dialysis and early referral for transplantation might help to improve eligibility of renal transplant candidates.
Long‐term follow‐up of immunosuppressive monotherapy in liver transplantation: tacrolimus and microemulsified cyclosporin
Authors: Cholongitas Evangelos , Shusang Vibhakorn , Germani Giacomo , Tsochatzis Emmanuel , Raimondo Maria Luisa , Marelli Laura , Senzolo Marco , Davidson Brian R. , Patch David , Rolles Keith , Burroughs Andrew K. 
Published: August 2010

Cholongitas E, Shusang V, Germani G, Tsochatzis E, Raimondo ML, Marelli L, Senzolo M, Davidson BR, Patch D, Rolles K, Burroughs AK. Long‐term follow‐up of immunosuppressive monotherapy in liver transplantation: tacrolimus and microemulsified cyclosporin. Clin Transplant 2011: 25: 614–624. © 2010 John Wiley & Sons A/S.Abstract:  Background:  Early withdrawal of steroids after liver transplantation has benefits, but rarely is total avoidance of steroids used. We evaluated long‐term results of patients with ab initio monotherapy with cyclosporin (CYA) vs. tacrolimus (TAC), in randomized and cohort studies.Methods:  We evaluated long‐term outcomes in 66 adults randomized to TAC or CYA and 94 subsequent patients who received TAC. Protocol liver biopsies were performed. Rejection was treated with three 1 g/d methylprednisolone. Further rejection after two courses of methylprednisolone was defined as monotherapy failure.Results:  Actuarial five‐yr survival was 68% in TAC and 70% CYA. Monotherapy failed in 8% TAC and 13% CYA patients; no rejection in 24% TAC and 19% CYA patients; 42% TAC and 33% CYA patients were not exposed to any steroids. Rejection episodes were less with TAC, compared to CYA: mean 1.8 vs. 2.5, p = 0.042. Chronic rejection occurred in only 4 (11%) CYA patients. During follow‐up of median 97 months (range: 0.06–145), there were 16 (44%) deaths in CYA and 48 (39%) in TAC patients (p > 0.05).Conclusions:  TAC monotherapy ab initio is a viable immunosuppressive strategy in liver transplantation and was associated with lower rejection rates and renal complications, compared to CYA.
Difficulty in sustaining hepatic outflow in left lobe but not right lobe living donor liver transplantation
Authors: Shirouzu Yasumasa , Ohya Yuki , Hayashida Shintarou , Asonuma Katsuhiro , Inomata Yukihiro 
Published: August 2010

Shirouzu Y, Ohya Y, Hayashida S, Asonuma K, Inomata Y. Difficulty in sustaining hepatic outflow in left lobe but not right lobe living donor liver transplantation. Clin Transplant 2011: 25: 625–632. © 2010 John Wiley & Sons A/S.Abstract:  Background:  Hepatic outflow block is one of the major complications leading to severe graft dysfunction after left lobe living donor liver transplantation (LDLT).Methods:  Medical records of 46 recipients of a left lobe LDLT were reviewed. The method of outflow reconstruction and post‐transplant morphological changes of hepatic veins were investigated. The subjects were followed up until September 2008, with a median follow‐up period of 2.0 yr (range: 0.5–5.9 yr).Results:  There were no multiple outflow tracts to be reconstructed, and the median caliber of the single orifices with or without venoplasty was 32.0 mm. The difference between the angle of hepatic veins to the sagittal plane measured on computed tomography was calculated for pre‐operative donors and post‐operative recipients a month after LDLT. Both left and middle hepatic veins showed a significantly greater change in angle than the right hepatic vein. Both left and middle hepatic veins more frequently showed a nearly flat wave form on Doppler study one month after LDLT. In the 46 recipients of left lobe grafts, three developed outflow block (6.5%).Conclusions:  The middle and left hepatic veins tend to distort and stretch during graft regeneration. These characteristics seem to be associated with outflow disturbances.
Lamotrigine versus lithium as maintenance treatment in bipolar I disorder: an open, randomized effectiveness study mimicking clinical practice. The 6th trial of the Danish University Antidepressant Group (DUAG‐6)
Authors: Licht Rasmus W , Nielsen Jannie N , Gram Lars F , Vestergaard Per , Bendz Hans 
Published: August 2010

Licht RW, Nielsen JN, Gram LF, Vestergaard P, Bendz H. Lamotrigine versus lithium as maintenance treatment in bipolar I disorder: an open, randomized effectiveness study mimicking clinical practice. The 6th trial of the Danish University Antidepressant Group (DUAG‐6). Bipolar Disord 2010: 12: 483–493. © 2010 The Authors. Journal compilation © 2010 John Wiley & Sons A/S.Objectives:  In industry‐generated pivotal studies, lamotrigine has been found to be superior to placebo and comparable to lithium in the maintenance treatment of bipolar I disorder. Here, we directly compared lamotrigine to lithium under conditions similar to clinical routine conditions.Methods:  Adult bipolar I disorder patients with at least two episodes within the last five years and an index episode requiring treatment were randomized to lithium (n = 78; doses adjusted to obtain serum levels of 0.5–1.0 mmol/L) or to lamotrigine (n = 77; up‐titrated to 400 mg/day) as maintenance treatments. Randomization took place when clinically appropriate, and comedication was allowed within the first six months after randomization. The patients were enrolled from March 2001 to December 2005, and observations were censored December 2006, allowing a subgroup of patients to be followed for more than five years. The primary outcome measure was time to predefined endpoints indicating insufficient maintenance treatment, and the major secondary outcome measure was time to any study endpoint. Data were analyzed primarily by Cox proportional regression models.Results:  For the primary outcome measure, the crude Hazard Rate Ratio (HRR) (lamotrigine relative to lithium) was 0.92 [95% confidence interval (CI): 0.60–1.40]. When the primary endpoints were broken down by polarity, the HRRs (lamotrigine relative to lithium) for mania and depression were, respectively, 1.91 (95% CI: 0.73–5.04) and 0.69 (95% CI: 0.41–1.22). There was no between‐group difference in terms of staying in study [HRR: 0.85 (95% CI: 0.61–1.19)]. Most treatment failures occurred within the first 1.5 years of treatment, and, among patients followed for at least five years, practically no patients were maintained successfully on monotherapy with either of the drugs. The lithium‐treated patients reported diarrhea, tremor, polyuria, and thirst more frequently. Two cases, probably lamotrigine‐related, of benign rash occurred.Conclusions:  No differences in maintenance effectiveness between lithium and lamotrigine could be demonstrated. Lamotrigine was better tolerated than lithium, but apparently this did not influence the outcome.
Metabolic dysfunction in women with bipolar disorder: the potential influence of family history of type 2 diabetes mellitus
Authors: Rasgon Natalie L , Kenna Heather A , Reynolds‐May Margaret F , Stemmle Pascale G , Vemuri Mytilee , Marsh Wendy , Wang Po , Ketter Terence A 
Published: August 2010

Rasgon NL, Kenna HA, Reynolds‐May MF, Stemmle PG, Vemuri M, Marsh W, Wang P, Ketter TA. Metabolic dysfunction in women with bipolar disorder: the potential influence of family history of type 2 diabetes mellitus.  Bipolar Disord 2010: 12: 504–513. © 2010 The Authors. Journal compilation © 2010 John Wiley & Sons A/S.Objective:  Overweight/obesity, insulin resistance (IR), and other types of metabolic dysfunction are common in patients with bipolar disorder (BD); however, the pathophysiological underpinnings of metabolic dysfunction in BD are not fully understood. Family history of type 2 diabetes mellitus (FamHxDM2), which has been shown to have deleterious effects on metabolic function in the general population, may play a role in the metabolic dysfunction observed in BD.Methods:  Using multivariate analysis of variance, the effects of BD illness and/or FamHxDM2 were examined relative to metabolic biomarkers in 103 women with BD and 36 healthy, age‐matched control women.Results:  As a group, women with BD had higher levels of fasting plasma insulin (FPI) and fasting plasma glucose (FPG), higher homeostatic assessment of IR (HOMA‐IR) scores, body mass index (BMI), waist circumference (WC), and hip circumference (HC) compared to control women. FamHxDM2 was associated with significantly worse metabolic biomarkers among women with BD but not among healthy control women. Among women with BD, there was a significant main effect of FamHxDM2 on FPI, HOMA‐IR, BMI, WC, and HC, even after controlling for type of BD illness, duration of medication exposure, and depression severity. Metabolic biomarkers were not influenced by use of weight‐liable psychotropic medication (WLM), even after controlling for type of BD illness, duration of medication exposure, and depression severity.Conclusions:  Women with BD have overall worse metabolic biomarkers than age‐matched control women. The use of WLM, duration of medication use, type of BD illness, and depression severity did not appear to be associated with more pronounced metabolic dysfunction. FamHxDM2 may represent a risk factor for the development of IR in women with BD. Further, focused studies of the endocrine profiles of families of BD patients are needed.
Performance of the Bipolar Spectrum Diagnostic Scale in psychiatric outpatients
Authors: Zimmerman Mark , Galione Janine N , Chelminski Iwona , Young Diane , Ruggero Camilo J 
Published: August 2010

Zimmerman M, Galione JN, Chelminski I, Young D, Ruggero CJ. Performance of the Bipolar Spectrum Diagnostic Scale in psychiatric outpatients. Bipolar Disord 2010: 12: 528–538. © 2010 The Authors. Journal compilation © 2010 John Wiley & Sons A/S.Objectives:  Recent research has suggested that bipolar disorder, when defined to include milder variants such as bipolar II disorder and bipolar disorder not otherwise specified (NOS), is more prevalent than had been previously reported and often underrecognized. Recommendations for improving the detection of bipolar disorder have included careful clinical evaluations inquiring about a history of mania and hypomania and the use of screening questionnaires. The Bipolar Spectrum Diagnostic Scale (BSDS) was designed to be particularly sensitive to the milder variants of bipolar disorder. In the present report from the Rhode Island Methods to Improve Diagnostic Assessment and Services (MIDAS) project, we examined the operating characteristics of the BSDS in a large sample of psychiatric outpatients presenting for treatment.Methods:  A total of 1,100 psychiatric outpatients were interviewed with the Structured Clinical Interview for DSM‐IV and asked to complete the BSDS. Missing data on the BSDS reduced the sample size to 961, approximately 10% (n = 90) of whom were diagnosed with bipolar disorder.Results:  The sensitivity of the BSDS was similar for bipolar I disorder, bipolar II disorder, and bipolar disorder NOS/cyclothymia. A receiver operating curve (ROC) analysis indicated that cutoffs of 11 and 12 maximized the sum of sensitivity and specificity for the entire group of patients with bipolar disorder (area under curve = 0.80, p < 0.001). The cutoff point associated with 90% sensitivity for the entire sample of patients with bipolar disorder was 8. At this cutoff the specificity of the scale was 51.1% and positive predictive value was 16.0%. We compared the patients with and without bipolar disorder on each of the BSDS symptom items. The odds ratios were higher for the items assessing hypomanic/manic symptoms than items assessing depressive symptoms. We therefore examined the performance of a subscale composed only of the hypomania/mania items. The area under the curve in the ROC analysis was nearly identical to that of the entire scale (0.81, p < 0.001).Conclusions:  With its high negative predictive value, the BSDS was excellent at ruling out a diagnosis of bipolar disorder; however, the low positive predictive value indicates that it is not good at ruling in the diagnosis. These data raise questions about the use of the BSDS as a screening measure in routine clinical psychiatric practice.
Circadian rhythms and sleep in bipolar disorder
Authors: Murray Greg , Harvey Allison 
Published: August 2010

Murray G, Harvey A. Circadian rhythms and sleep in bipolar disorder. Bipolar Disord 2010: 12: 459–472. © 2010 The Authors. Journal compilation © 2010 John Wiley & Sons A/S.Objective:  Biological rhythm pathways are highlighted in a number of etiological models of bipolar disorder, and the management of circadian instability appears in consensus treatment guidelines. There are, however, significant conceptual and empirical limitations on our understanding of a hypothesised link between circadian, sleep, and emotion regulation processes in bipolar disorder. The aim of this article is to articulate the limits of scientific knowledge in relation to this hypothesis.Methods:  A critical evaluation of various literatures was undertaken. The basic science of circadian and sleep processes, their involvement in normal emotion regulation, and the types of evidence suggesting circadian/sleep involvement in bipolar disorder are reviewed.Results:  Multiple lines of evidence suggest that circadian and sleep‐wake processes are causally involved in bipolar disorder. These processes demonstrably interact with other neurobiological pathways known to be important in bipolar disorder, but are unique in that they are open to behavioural manipulation.Conclusion:  Further research into biological rhythm pathways to bipolar disorder is warranted. Person‐environment feedback loops are fundamental to circadian adaptation, and models of circadian pathogenesis (and treatment) should recognize this complexity.
The effects of methylene blue on ovine post‐pneumonectomy pulmonary oedema
Authors: SUBOROV E. V. , KUZKOV V. V. , SOBHKHEZ M. , KIROV M. Y. , BJERTNAES L. J. 
Published: August 2010

Background: We recently reported that post‐pneumonectomy pulmonary oedema (PPO) occurs after ventilating the remaining lung with excessive tidal volumes. Studies in small animals have indicated that nitric oxide (NO) release increases in hyper‐inflated lungs, but confirmatory evidence from larger animals is still lacking. We hypothesized that PPO could be prevented by methylene blue (MB), an inhibitor of NO synthase.Methods: Sheep were subjected to a right‐sided pneumonectomy (PE) and randomly assigned to a protectively ventilated group ((PROTV group, n=7) with tidal volumes of 6 ml/kg at 20 inflations/min and a positive end‐expiratory pressure (PEEP) of 2 cmH2O, and two groups undergoing ‘injurious ventilation’ (INJV) with tidal volumes of 12 ml/kg and zero end‐expiratory pressure (ZEEP), a control group (INJV group, n=7) and a treatment group subjected to MB 1 h after PE (INJV+MB group, n=7). Haemodynamic variables, lung mechanics, blood gases and plasma nitrites and nitrates (NOx) were determined.Results: PE reduced pulmonary blood volume, extravascular lung water (EVLWI) and quasistatic lung compliance in all groups, in parallel with a rise in peak airway pressure (P<0.05). In the INJV group, pulmonary arterial pressure, EVLWI and pulmonary vascular permeability index increased and arterial oxygenation decreased towards cessation of the experiments. These changes were not antagonized by MB. Plasma NOx increased in all the groups compared with baseline, but with no intergroup difference.Conclusion: MB did not reduce PPO and accumulation of NOx in sheep subjected to ventilation with excessive tidal volumes and ZEEP.
Kinetic analyses of plant water relocation using deuterium as tracer – reduced water flux of Arabidopsis pip2 aquaporin knockout mutants
Authors: Da Ines O. , Graf W. , Franck K. I. , Albert A. , Winkler J. B. , Scherb H. , Stichler W. , Schäffner A. R. 
Published: August 2010

AbstractDue to reduced evaporation and diffusion of water molecules containing heavier isotopes, leaf water possesses an elevated 18O or 2H steady‐state content. This enrichment has been exploited in plant physiology and ecology to assess transpiration and leaf water relations. In contrast to these studies, in this work the 2H content of the medium of hydroponically grown Arabidopsis thaliana was artificially raised, and the kinetics of 2H increase in the aerial parts recorded during a short phase of 6–8 h, until a new equilibrium at a higher level was reached. A basic version of the enrichment models was modified to establish an equation that could be fitted to measured leaf 2H content during uptake kinetics. The fitting parameters allowed estimation of the relative water flux qleaf into the Arabidopsis rosette. This approach is quasi‐non‐invasive, since plants are not manipulated during the uptake process, and therefore, offers a new tool for integrated analysis of plant water relations. The deuterium tracer method was employed to assess water relocation in Arabidopsis pip2;1 and pip2;2 aquaporin knockout plants. In both cases, qleaf was significantly reduced by about 20%. The organ and cellular expression patterns of both genes imply that changes in root hydraulic conductivity, as previously demonstrated for pip2;2 mutants, and leaf water uptake and distribution contributed in an integrated fashion to this reduced flux in intact plants.