bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term effectiveness of secondary prevention in geriatric nurses with occupational hand eczema: the challenge of a controlled study design
Authors: Wilke Annika , Gediga Kathrin , Weinhöppel Ulrike , John Swen Malte , Wulfhorst Britta 
Published: October 2011

Background. The high prevalence of occupational dermatoses indicates the need for effective and sustainable prevention strategies.Objectives. To evaluate the long‐term effectiveness of secondary prevention in geriatric nurses.Patients/Methods. One hundred and two geriatric nurses with occupational hand eczema participated in an interdisciplinary prevention programme [intervention group (IG)]. Members of the control group (CG) (n = 107) were medically treated by local dermatologists. Six years after intervention (T2), data on job continuation, skin lesions and skin protection behaviour were obtained by standardized questionnaires and compared with baseline values (T0) and data from a 3‐month follow‐up (T1).Results. At T2, 65.3% of the IG and 56.8% of the CG still worked as geriatric nurses; 6.9% of the IG and 13.6% of the CG had given up work because of occupational hand eczema. The skin status improved in both cohorts. The data indicated a lower frequency of skin lesions and morphological signs in the IG, for example vesicles (IG, 12.8%; CG, 40.0%; χ2 = 7.00, degrees of freedom = 1, p = 0.008).Conclusions. The results indicate long‐term effects regarding job continuation and disease severity, although few results showed statistical significance. It is outlined that controlled long‐term studies aiming at proving the general effectiveness of secondary prevention are no longer feasible in Germany, as the statutory accident insurance has led to a legal entitlement of all patients affected by occupational hand eczema to immediate preventive intervention.
CONSUMER ATTITUDES AND EXPECTATIONS OF GINSENG FOOD PRODUCTS ASSESSED BY FOCUS GROUPS AND CONJOINT ANALYSIS
Authors: CHUNG HEE SOOK , HONG HEE‐DO , KIM KYUNGTACK , CHO CHANG‐WON , MOSKOWITZ HOWARD R. , LEE SOO‐YEUN 
Published: October 2011

ABSTRACTGinseng food products in the U.S.A. have mostly been limited to beverages despite the growth of functional foods market. The objectives of the study were to: (1) probe consumer attitudes and expectations of ginseng food products in the U.S.A., and (2) identify ginseng food product concept(s) that possess market potential in the U.S.A. Focus group panel (n = 14) experienced limited types of ginseng food products from the Asian market and suggested that new ginseng food products be developed on the basis of preexisting product types in the U.S.A. Conjoint analysis (n = 400) was performed with four categories and five elements from each category, which were generated based on findings from preceding focus groups. Participants had a low level of initial interest in ginseng food products. “Sweetness” and “ginseng chocolate” had the highest utility values. Findings suggested that the original ginseng flavors, including bitterness and earthiness, be minimized in order to establish potential for success in the U.S. market.PRACTICAL APPLICATIONSThis present work demonstrates consumers' insights and expectations of ginseng food products as well as ginseng food product concepts that drive consumers' interests, which have not been extensively researched in the U.S.A. Moreover, findings from the study demonstrate U.S. consumers' knowledge and insights of ginseng and its health effects. These will help food manufacturers understand the consumers who are latent in purchasing ginseng food products in the market and develop ginseng food products that will ensure their success in the U.S. market. Segmentation of consumers based on the pattern of their responses to the concept elements will be beneficial for food‐marketing experts to establish marketing strategies. New ginseng food products where the findings from the study are applied are expected to increase consumers' intent to purchase the products, which have been known as containing numerous bioactive compounds.
DO THE MATERIAL PROPERTIES OF CUTLERY AFFECT THE PERCEPTION OF THE FOOD YOU EAT? AN EXPLORATORY STUDY
Authors: PIQUERAS‐FISZMAN BETINA , SPENCE CHARLES 
Published: October 2011

ABSTRACTOur perception of food depends both on the contextual conditions in which it is presented and on the way the food is consumed; hence, the current trend toward investigating these contextual variables in empirical research. In most meal situations, people interact with the food that they consume by means of a variety of accessories, such as dishes and cutlery that fulfill the consumers' functional requirements. However, despite the important role that these accessory stimuli play during the consumption of food, little research has been carried out in order to investigate how they may affect food perception. The present preliminary study was therefore undertaken in order to explore how the cutlery, specifically two teaspoons (a plastic one with metallic finish and a stainless steel one), affected consumers' sensory and hedonic perception of yoghurt. Consumers' quality and liking judgments concerning identical yoghurt samples differed significantly when tasted either with a metallic plastic spoon or else with a stainless steel spoon, the latter resulting in significantly higher scores.PRACTICAL APPLICATIONSThese results contribute to our knowledge of how contextual variables affect a consumer's perception of food. These findings open up new research directions emphasizing the potential importance of the properties of cutlery and its influence on consumers' perception of food. These results are relevant to product development and to caterers and restaurateurs because different dishes (i.e., foodstuffs/flavors) could be matched with different types of cutlery in order to increase convenience and, at the same, time potentially enhance the consumers' eating experience.
Visual field progression outcomes in glaucoma subtypes
Authors: De Moraes Carlos Gustavo , Liebmann Jeffrey M. , Liebmann Craig A. , Susanna Remo , Tello Celso , Ritch Robert 
Published: October 2011

Abstract.Purpose:  To determine whether glaucoma subtype is an independent risk factor for visual field (VF) progression.Methods:  We reviewed the charts of glaucoma suspects and glaucoma patients seen in a referral practice between 1999 and 2009. Automated pointwise linear regression analysis determined the rates of VF change. A progression endpoint was determined when two or more adjacent test locations in the same hemifield showed a threshold sensitivity decline at a rate of ≥1.0 dB/year with p < 0.01.Results:  We included 841 eyes (841 patients; mean age, 64.1 ± 12.6 years; mean number of VF tests, 10.8 ± 2.8; mean follow‐up, 6.4 ± 1.7 years). The glaucomatous group consisted of angle‐closure glaucoma (76 eyes), juvenile primary open‐angle glaucoma (37 eyes), normal‐tension glaucoma (81 eyes), pigmentary glaucoma (34 eyes), primary open‐angle glaucoma (275 eyes) and exfoliative glaucoma (XFG, 84 eyes). Normal‐tension glaucoma eyes were more likely to present with beta‐zone parapapillary atrophy and disc haemorrhage (p < 0.01). Exfoliative glaucoma eyes had the fastest rates of global VF change (−0.65 dB/year), as well as the highest mean, fluctuation, and peak intraocular pressure during follow‐up (16.5, 3.0 and 22.0 mmHg, respectively) and reached a progression endpoint more frequently (40%). After adjusting for all covariates, including the glaucoma phenotype, there was no difference among groups regarding global rates of VF change and the risk of reaching a progression endpoint.Conclusions:  Despite different clinical features, epidemiology and genetics, glaucoma phenotype is not an independent risk factor for VF progression. Rather, variations in well‐known, reported risk factors remain important disease parameters that affect progression.
Sporothrix schenckii and Sporotrichosis
Authors: Barros Mônica Bastos de Lima , de Almeida Paes Rodrigo , Schubach Armando Oliveira 
Published: October 2011

SUMMARYSporotrichosis, which is caused by the dimorphic fungusSporothrix schenckii, is currently distributed throughout the world, especially in tropical and subtropical zones. Infection generally occurs by traumatic inoculation of soil, plants, and organic matter contaminated with the fungus. Certain leisure and occupational activities, such as floriculture, agriculture, mining, and wood exploitation, are traditionally associated with the mycosis. Zoonotic transmission has been described in isolated cases or in small outbreaks. Since the end of the 1990s there has been an epidemic of sporotrichosis associated with transmission by cats in Rio de Janeiro, Brazil. More than 2,000 human cases and 3,000 animal cases have been reported. In humans, the lesions are usually restricted to the skin, subcutaneous cellular tissue, and adjacent lymphatic vessels. In cats, the disease can evolve with severe clinical manifestations and frequent systemic involvement. The gold standard for sporotrichosis diagnosis is culture. However, serological, histopathological, and molecular approaches have been recently adopted as auxiliary tools for the diagnosis of this mycotic infection. The first-choice treatment for both humans and cats is itraconazole.
Human Metapneumovirus: Lessons Learned over the First Decade
Authors: Schildgen Verena , van den Hoogen Bernadette , Fouchier Ron , Tripp Ralph A. , Alvarez Rene , Manoha Catherine , Williams John , Schildgen Oliver 
Published: October 2011

SUMMARYIt has been 10 years since human metapneumovirus (HMPV) was identified as a causative agent of respiratory illness in humans. Since then, numerous studies have contributed to a substantial body of knowledge on many aspects of HMPV. This review summarizes our current knowledge on HMPV, HMPV disease pathogenesis, and disease intervention strategies and identifies a number of areas with key questions to be addressed in the future.
Characterization of a new 4BS.7HL wheat–barley translocation line using GISH, FISH, and SSR markers and its effect on the β-glucan content of wheat
Authors: Cseh A. , Kruppa K. , Molnár I. , Rakszegi M. , Doležel J. , Molnár-Láng M. 
Published: October 2011

A spontaneous interspecific Robertsonian translocation was revealed by genomic in situ hybridization (GISH) in the progenies of a monosomic 7H addition line originating from a new wheat ‘Asakaze komugi’ × barley ‘Manas’ hybrid. Fluorescence in situ hybridization (FISH) with repetitive DNA sequences (Afa family, pSc119.2, and pTa71) allowed identification of all wheat chromosomes, including wheat chromosome arm 4BS involved in the translocation. FISH using barley telomere- and centromere-specific repetitive DNA probes (HvT01 and (AGGGAG)n) confirmed that one of the arms of barley chromosome 7H was involved in the translocation. Simple sequence repeat (SSR) markers specific to the long (L) and short (S) arms of barley chromosome 7H identified the translocated chromosome segment as 7HL. Further analysis of the translocation chromosome clarified the physical position of genetically mapped SSRs within 7H, with a special focus on its centromeric region. The presence of the HvCslF6 gene, responsible for (1,3;1,4)-β-d-glucan production, was revealed in the centromeric region of 7HL. An increased (1,3;1,4)-β-d-glucan level was also detected in the translocation line, demonstrating that the HvCslF6 gene is of potential relevance for the manipulation of wheat (1,3;1,4)-β-d-glucan levels.
A bacterial artificial chromosome library for ‘Jefferson’ hazelnut and identification of clones associated with eastern filbert blight resistance and pollen–stigma incompatibility
Authors: Sathuvalli Vidyasagar R. , Mehlenbacher Shawn A. 
Published: October 2011

European hazelnut ( Corylus avellana L.) is the only economically important nut crop in the family Betulaceae. Because of its small genome size (~385 Mb / 1C), relatively short life cycle, availability of a dense linkage map, and amenability to transformation by Agrobacterium, the European hazelnut could serve as a model plant for the Betulaceae. Here we report the construction of a bacterial artificial chromosome (BAC) library for ‘Jefferson’ hazelnut using the cloning enzyme MboI and the vector pECBAC1 (BamHI site). The library consists of 39 936 clones arrayed in 104 384-well microtitre plates with a mean insert size of 117 kb. The genomic coverage of the library is estimated to be about 12 genome equivalents. This library provides a valuable resource for the map-based cloning of two important genes, the resistance gene from ‘Gasaway’ that confers resistance to eastern filbert blight caused by the fungus Anisogramma anomala (Peck) E. Müller and the S locus that controls pollen–stigma incompatibility. Fine-resolution mapping near the two loci was carried out using random amplified polymorphic DNA (RAPD) and simple sequence repeat (SSR) markers. Fine mapping at the disease resistance locus showed that markers W07-375 and X01-825 flanked the resistance locus at distances of 0.06 and 0.05 cM, respectively. The S locus is flanked by markers 204-950 and KG819-200 at distances of 0.14 and 0.24 cM, respectively. Assuming that 1 cM corresponds to a physical distance of 430 kb, it will take approximately two to three chromosome walks to assemble BAC contigs that span both loci.
Understanding the Dual Nature of CD44 in Breast Cancer Progression
Authors: Louderbough Jeanne M.V. , Schroeder Joyce A. 
Published: October 2011

AbstractCD44 has been the subject of extensive research for more than 3 decades because of its role in breast cancer, in addition to many physiological processes, but interestingly, conflicting data implicate CD44 in both tumor suppression and tumor promotion. CD44 has been shown to promote protumorigenic signaling and advance the metastatic cascade. On the other hand, CD44 has been shown to suppress growth and metastasis. Histopathological studies of human breast cancer have correlated CD44 expression with both favorable and unfavorable clinical outcomes. In recent years, CD44 has garnered significant attention because of its utility as a stem cell marker and has surfaced as a potential therapeutic target, necessitating a greater understanding of CD44 in breast cancer. In this review, we attempt to unify the literature implicating CD44 in both tumor promotion and suppression, and explain its dualistic nature. Mol Cancer Res; 9(12); 1573–86. ©2011 AACR.
Prognostic Implications of Creatine Kinase-MB Elevation After Percutaneous Coronary Intervention
Authors: Lindsey Jason B. , Kennedy Kevin F. , Stolker Joshua M. , Gilchrist Ian C. , Mukherjee Debabrata , Marso Steven P. , Pencina Michael J. , Kleiman Neal S. , Cohen David J. 
Published: October 2011

Background—
Creatine kinase-MB (CK-MB) elevation after percutaneous coronary intervention (PCI) has been associated with increased risk for mortality. Although most studies have defined periprocedural myocardial infarction (pMI) as an elevation in CK-MB >3× upper limit of normal (ULN), use of different CK-MB assays and variation in site-specific definitions of the ULN may limit the value of such relative thresholds.

Methods and Results—

We used data from the multicenter Evaluation of Drug-Eluting Stents and Ischemic Events (EVENT) registry to examine the impact of variations in site-specific thresholds for CK-MB elevation on the incidence of pMI as well as the relationship between absolute peak levels of CK-MB after PCI and 1-year mortality. The study cohort consisted of 6347 patients who underwent nonemergent PCI and had normal CK-MB at baseline. Across the 59 study centers, the ULN for CK-MB ranged from 2.6 to 10.4 ng/mL (median, 5.0 ng/mL), and there was an inverse relationship between the site-specific ULN and the incidence of pMI (defined as CK-MB elevation >3× ULN). Although any postprocedure elevation of CK-MB was associated with an adverse prognosis, in categorical analyses, only CK-MB ≥50 ng/mL was independently associated with increased 1-year mortality (hazard ratio, 4.71; 95% confidence interval, 2.42 to 9.13;
P
<0.001). Spline analysis using peak CK-MB as a continuous variable suggested a graded, nonlinear relationship with 1-year mortality, with an inflection point at ≈30 ng/mL.

Conclusions—
Among unselected patients undergoing PCI, there is a graded relationship between CK-MB elevation after PCI and 1-year mortality that is particularly strong for large CK-MB elevations (>30 to 50 ng/mL). Future studies that include pMI as a clinical end point should consider using a core laboratory to assess CK-MB (to ensure consistency) and raising the threshold for defining pMI above current levels (to enhance clinical relevance).
The dilemma of diagnostic uncertainty when treating people with chronic low back pain: a qualitative study
Authors: Slade Susan Carolyn , Molloy Elizabeth , Keating Jennifer Lyn 
Published: October 2011

Objective: To investigate how physiotherapists prescribe execise for people with non-specific chronic low back pain in the absence of definitive or differential diagnoses. Design: Four guided focus groups were conducted to gather the views of physiotherapists working in primary care. Subjects and setting: Twenty-three primary care physiotherapists from metropolitan Melbourne, Australia, were identified from professional organization member lists and publicly available records. They were recruited via email and assembled for focus groups based on eligibility, availability and location. Main measures: Discussions were audio-taped, transcribed verbatim and analysed for themes by three independent researchers. Results: The ‘dilemma created by diagnostic uncertainty’ emerged as a significant overarching theme with the following subthemes. Physiotherapists: 1) perceive that care-seekers want a clear diagnosis, 2) are challenged by diagnostic uncertainty, 3) are critical when patients fail to improve, 4) feel unprepared by traditional education models and 5) seek support from experienced colleagues. Physiotherapists report needing to: 1) educate care-seekers about their injury/diagnosis, despite diagnostic uncertainty, and 2)observe rapid health outcome improvements. They exhibit potentially negative behaviours, including blame attribution, when this does not occur. Conclusions: Physiotherapists appear under-prepared for the challenges of working with people with chronic conditions. Quality research is warranted to determine best practice in supporting practitioners in the development of suitable therapeutic behaviours to deal with this challenging patient interface.
Inpatient versus home-based rehabilitation for older adults with musculoskeletal disorders: a systematic review
Authors: Stolee Paul , Lim Sarah N , Wilson Lindsay , Glenny Christine 
Published: October 2011

Objective: To review and summarize available evidence to compare the outcomes of home-based rehabilitation to inpatient rehabilitation for older patients with musculoskeletal conditions. Data sources: Relevant articles published prior to August 2011 were identified using MEDLINE, CINAHL and the Cochrane Central Register of Controlled Trials databases. Review methods: English-language articles that compared patient outcomes of home-based and inpatient rehabilitation for older adults were included. Outpatient care was not included as home-based or inpatient rehabilitation. Methodological quality of included studies was evaluated by two reviewers using the PEDro scale. Results: A systematic search yielded eight randomized controlled trials and four cohort studies. Older adults who received rehabilitation in the home had equal or higher gains than the inpatient group in function, cognition, and quality of life; they also reported higher satisfaction. Conclusion: Home-based rehabilitation may be an effective alternative for treating older patients with musculoskeletal conditions.
Primitive Accumulation and the Labor Subsidies to Capitalism
Authors: Wilson Tamar Diana 
Published: October 2011

It is argued in this paper, following the insights of Rosa Luxemburg and others, that primitive accumulation is a constant and ongoing process integral to capital accumulation. Concentrating on workers who are raised and sustained in times of unemployment by subsistence agriculture or informal income-generating activities by self or family members, often women, it is seen how their labor is commodified. The recurrent migration of parts of this global reserve army of labor, whether internally or transnationally, provides a variety of subsidies to capitalist enterprise. JEL classification: J16, J61, D13
Revisiting the Mexican Informality Continuum in the United States
Authors: Pisani Michael J. 
Published: October 2011

In this rejoinder, I respond to the recent RRPE paper by Cobb, King, and Rodriguez (2009) concerning Mexican immigrant economic informality in the United States. Specifically I assess the discussion of economic informality of Mexican immigrants. I end with a call for further research into this phenomenon that employs millions in the U.S. informal economy. JEL classification: F22, J15, J61, O17
Features associated with cardiac abnormalities in systemic lupus erythematosus
Authors: Bourré-Tessier J , Huynh T , Clarke AE , Bernatsky S , Joseph L , Belisle P , Pineau CA 
Published: October 2011

Objectives. To determine the prevalence of echocardiographic abnormalities and identify associated clinical and laboratory features in a large systemic lupus erythematosus (SLE) cohort. Methods. Patients fulfilling ACR criteria for SLE underwent a transthoracic echocardiogram (TTE) between January 2005 and June 2006. Variables used as potential correlates included age, sex, ethnicity, lupus duration, lupus disease activity (SLEDAI), cumulative damage (SLICC/ACR damage index (DI)), arterial hypertension, diabetes, current smoking, medication use and laboratory data. Multivariate logistic regression was used to examine the association between TTE abnormalities and potential determinants. Results. For the 217 subjects with a TTE performed during the study, the main abnormalities were of the mitral valve (37.3%) and included thickening (25.4%) and insufficiency (25.8%). Other findings included pulmonary artery pressure (PAP) ≥ 30 mm Hg (10.1%), pericardial effusion (4.6%), hypokinesis (2.8%), and aortic insufficiency (3.7%). In multivariate analysis, mitral insufficiency was associated with the use of corticosteroids (OR 2.90; 95%CI 1.42–5.94) and hypokinesis with angiotensin-converting enzyme inhibitors (12.89; 1.06–157.18). Elevated PAP was associated with age (1.04; 1.01–1.07) and with DI (1.20; 1.01–1.42). Conclusion. Valvular abnormalities are frequent in patients with SLE, with mitral valve lesions occurring in over one third. TTE screening may be indicated in patients with SLE, especially for those with identified risk factors such as corticosteroid use.