bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protolith age and provenance of metasedimentary rocks in Variscan allochthon units: U–Pb SHRIMP zircon data from the Orlica–Śnieżnik Dome, West Sudetes
Authors: JASTRZĘBSKI MIROSŁAW , ŻELAŹNIEWICZ ANDRZEJ , NOWAK IZABELLA , MURTEZI MENTOR , LARIONOV ALEXANDER N. 
Published: November 2009

AbstractNew U–Pb sensitive high-mass resolution ion microprobe (SHRIMP) data from detrital zircons within the Orlica–Śnieżnik Dome provide new insights into the stratigraphic and palaeogeographic position of assumed relict Precambrian basement preserved in the Variscan collisional orogen of the West Sudetes, SW Poland. Hitherto, the Młynowiec Formation and the Stronie Formation within the Orlica–Śnieżnik Dome were assumed to represent two metavolcano-sedimentary successions of Proterozoic and early Palaeozoic age, respectively. However, when previous U–Pb data and mapping data from the Orlica–Śnieżnik Dome are combined with the new detrital zircon isotopic ages both from paragneisses within the Młynowiec Formation and from light-coloured quartzites and mica schists within the Stronie Formation, the result strongly suggests that the protoliths of these two formations actually form a continuous succession. This continuous succession is herein designated the Młynowiec–Stronie Group. The rocks of this group were deposited during middle Cambrian–early Ordovician times (c.520–470 Ma), presumably at the northern edge of West Gondwana after the 10–20 Ma period of tectonic quiescence that followed the terminal stage of the Cadomian collisions. Monotonous Młynowiec metagreywackes form the lower part of the succession, and the lithologically diverse schistose Stronie Formation forms its upper part. The change from greywacke (Młynowiec) to volcano-sedimentary (Stronie) facies coincided with the onset of rather short-lived volcanic activity which climaxed around 505–495 Ma and which supplied the volcanogenic components to the Stronie Formation. No ‘Cadomian unconformity’ has been observed in the region. Xenocrystic zircons from the Młynowiec–Stronie Group retain records of Archaean (3.0–2.3 Ga), Palaeoproterozoic (2.1–1.8 Ga) and Neoproterozoic to early Cambrian (660–530 Ma) zircon-forming events. These zircon ages, together with the lack of 1.7–1.2 Ga zircon ages, suggest that the source areas for the metasedimentary rocks may have been the West Africa craton, which therefore differs from the Amazonian affinity of the adjacent Brunovistulia Terrane. Nevertheless, two zircons,c.1.0 and 1.1 Ga old, respectively, indicate that the Młynowiec–Stronie Group sedimentary basin must have still been within the delivery reach of detritus ultimately derived from the Grenvillian-age belt(s). The detrital components of the supracrustal formations of the Orlica–Śnieżnik Dome were mainly derived from Neoproterozoic zircon-bearing crystalline rocks that were accreted to, and included in, the Cadomian basement in several intrusive pulses that culminated at 660–640 Ma, 620 Ma and 570–530 Ma.
Epidemiology and associated factors for nosocomial methicillin-resistant Staphylococcus aureus infection in a tertiary-care hospital
Authors: SACAR S. , SAYIN KUTLU S. , TURGUT H. , CEVAHIR N. , HIRCIN CENGER D. , TEKIN K. 
Published: November 2009

SUMMARYWe analysed nosocomial MRSA cases between January 2004 and December 2006 in a retrospective case-control study in a 250-bed tertiary-care teaching hospital. During the study period, 265 nosocomial Staphylococcus aureus infections were identified in 231 patients. There was a significant increase in methicillin resistance in isolates (MRSA) from these infections with frequencies for 2004 of 39/88 (44·3%), 2005 (62/80, 77·5%), and 2006 (75/97, 77·3%) (P<0·001). Multivariate analysis showed that associated factors for nosocomial MRSA infection were prolonged hospitalization (OR 3·982, 95% CI 2·235–7·094, P<0·001), mechanical ventilation (OR 3·052, 95% CI 1·666–5·590, P<0·001), surgical operation (OR 2·032, 95% CI 1·102–3·748, P=0·023), and male sex (OR 2·000, 95% CI 1·081–3·699, P=0·027). The determination of associated factors for methicillin resistance in nosocomial S. aureus infections in hospitals will play an important role in efforts to reduce MRSA infection rates.
Delayed wound healing in elderly people
Authors: Thomason Helen A. , Hardman Matthew J. 
Published: November 2009

SummaryOur ability to heal wounds deteriorates with age, leading in many cases to a complete lack of repair and development of a chronic wound. Moreover, as the elderly population continues to grow the prevalence of non-healing chronic wounds is escalating. Cutaneous wound repair occurs through a combination of overlapping phases, including an initial inflammatory response, a proliferative phase and a final remodelling phase. In elderly subjects the inflammatory response is delayed, macrophage and fibroblast function compromised, angiogenesis reduced and re-epithelialization inhibited. Whilst a large body of historic research describes the defective processes that lead to delayed healing, only recently have the molecular mechanisms by which these defects arise begun to be elucidated. Current therapies available for treatment of chronic wounds in elderly people are surprisingly limited and generally ineffective. Thus there is an urgent need to develop new therapeutic strategies based on these recent molecular and cellular insights.
Small-scale seed-bank patterns in a forest soil
Authors: Plue Jan , Goyens Geertrui , Van Meirvenne Marc , Verheyen Kris , Hermy Martin 
Published: November 2009

AbstractThe forest seed bank has been demonstrated to vary spatially at scales from 2 to 10 m. To our knowledge, the fine-scale spatial structure, i.e. < 2 m, has not been studied before. This study aims to make a thorough investigation of fine-scale spatial structure. Soil samples (128) were collected from each of five 2.1 m × 2.1 m plots, using a combined systematic (64) and random design (64). This allowed investigation of the fine-scale spatial structure of individual species–plot combinations using indicator-variograms. Our results indicated that over half of all species recorded in a particular plot were spatially structured. Remarkably, the presence of spatial structure seemed independent of species frequency. Visualization of the spatial structure showed an irregular spatial pattern, i.e. seed clusters that were randomly distributed in space. Spatial dependence occurred over small distances, possibly suggesting that a significant proportion of seeds was deposited near the mother plant. We conclude by presenting the relevance and implications of small-scale spatial seed-bank patterning for seed-bank sampling.
The mobility transition revisited, 1500–1900: what the case of Europe can offer to global history
Authors: Lucassen Jan , Lucassen Leo 
Published: November 2009

AbstractHistorians of migration have increasingly criticized the idea of a ‘mobility transition’, which assumed that pre-modern societies in Europe were geographically fairly immobile, and that people only started to move in unprecedented ways with the onset of modernization in the nineteenth century. In line with this critique, this article attempts to apply thorough quantitative tests to the available data. The focus is on ‘cross-community migration’, following Patrick Manning's argument that migrants moving over a cultural border are most likely to accelerate the rate of innovation. Six forms of migration are considered: emigration out of Europe, immigration from other continents, rural colonization of ‘empty spaces’, movements to large cities, seasonal migration, and the movement of sailors and soldiers. To illustrate regional variations, the examples of the Netherlands and Russia are contrasted. The reconstruction presented here is partial and preliminary, but it unequivocally shows that early modern Europe was much more mobile than modernization scholars allowed for. There was indeed a sharp increase in the level of migration after 1850, but it was due to improvements in transport rather than to modernization in a more general sense. This model has been elaborated for Europe but it can also be applied to other parts of the world and can hopefully contribute to the debate on the ‘Great Divergence’ between Europe and Asia.
State formation and urbanization trajectories: state finance in the Ottoman Empire before 1800, as seen from a Dutch perspective
Authors: Fritschy Wantje 
Published: November 2009

AbstractLooking at state finance in the Ottoman Empire from a Dutch perspective shows remarkable differences between the two systems. This article suggests that these differences were related to the fact that, in contrast to those in the Ottoman Empire, fiscal systems in western Europe, and especially in the Netherlands, developed within a context of economy-driven rather than state-driven trajectories of urbanization. This gave rise to separate systems of urban public finance, which enhanced possibilities for funding a debt serviced by indirect urban taxes, the root of later state debts. In Ottoman cities, systems of urban public finance managed by urban governments did not develop, thus precluding a similar development.
Historical globalization and colonial legal culture: African assessors, customary law, and criminal justice in British Africa
Authors: Ibhawoh Bonny 
Published: November 2009

AbstractThe idea of globalization has helped to rehabilitate universalizing categories, such as colonialism and cosmopolitanism, criticized for their tendency to ignore the differences between local cultures and the operation of power. Drawing on the burgeoning discussion on historical globalization, and focussing on the role of African assessors, this article examines how colonial courts grappled with the tension between the aspiration toward imperial legal universalism and the ‘Othering’ of African subjects. It argues that British colonialism in Africa represented a form of globalization of English law, generating a ‘centripetal jurisprudence’ that sought to square the inequities of an engagement with local custom by holding up the values of justice, equity, and conscience. Imperial legal universalism required both the accommodation and containment of African difference. The paradox of integration and differentiation in colonial constructions of globality is that imperial power and local cultures were not always in conflict, but were sometimes complementary and mutually reinforcing.
Reflections on the transnational turn in United States history: theory and practice
Authors: Tyrrell Ian 
Published: November 2009

AbstractThis article situates the idea of ‘transnational history’ within the recent historiography of the United States, as both a reaction against and accommodation to the nation-state focus of that historiography. It explains transnational history's specific American development as a broad project of research to contextualize US history and decentre the nation; it explores the conditions of American historical practice that influenced the genesis and growth of this version of transnational history; and it compares the concept with competitor terms such as international history, comparative history, global history, histoire croisée,and trans-border. In the United States, transnational history came to be considered complementary to these concepts in its commitment to render American historiography less parochial, yet, because of its origins, the concept has remained limited in application by period and spatial scope. While the concept retains utility because of its specific research programme to denaturalize the nation, transnational history understood as an exploration of ‘transnational spaces’ opens possibilities for an approach of more general historiographical relevance.
Brd2 disruption in mice causes severe obesity without Type 2 diabetes
Authors: Wang Fangnian , Liu Hongsheng , Blanton Wanda P. , Belkina Anna , Lebrasseur Nathan K. , Denis Gerald V. 
Published: November 2009

Certain human subpopulations are metabolically healthy but obese, or metabolically obese but normal weight; such mutations uncouple obesity from glucose intolerance, revealing pathways implicated in Type 2 diabetes. Current searches for relevant genes consume significant effort. We have reported previously a novel double bromodomain protein called Brd2, which is a transcriptional co-activator/co-repressor with SWI/SNF (switch mating type/sucrose non-fermenting)-like functions that regulates chromatin. In the present study, we show that wholebody disruption of Brd2, an unusual MHC gene, causes lifelong severe obesity in mice with pancreatic islet expansion, hyperinsulinaemia, hepatosteatosis and elevated pro-inflammatory cytokines, but, surprisingly, enhanced glucose tolerance, elevated adiponectin, increased weight of brown adipose tissue, heat production and expression of mitochondrial uncoupling proteins in brown adipose tissue, reduced macrophage infiltration in white adipose tissue, and lowered blood glucose, leading to an improved metabolic profile and avoiding eventual Type 2 diabetes. Brd2 is highly expressed in pancreatic β-cells, where it normally inhibits β-cell mitosis and insulin transcription. In 3T3-L1 pre-adipocytes, Brd2 normally co-represses PPAR-γ (peroxisome-proliferator-activated receptor-γ) and inhibits adipogenesis. Brd2 knockdown protects 3T3-L1 adipocytes from TNF-α (tumour necrosis factor-α)-induced insulin resistance, thereby decoupling inflammation from insulin resistance. Thus hypomorphic Brd2 shifts energy balance toward storage without causing glucose intolerance and may provide a novel model for obese metabolically healthy humans.
The oxyanion hole ofPseudomonas fluorescensmannitol 2-dehydrogenase: a novel structural motif for electrostatic stabilization in alcohol dehydrogenase active sites
Authors: Klimacek Mario , Nidetzky Bernd 
Published: November 2009

The side chains of Asn191 and Asn300 constitute a characteristic structural motif of the active site of Pseudomonas fluorescens mannitol 2-dehydrogenase that lacks precedent in known alcohol dehydrogenases and resembles the canonical oxyanion binding pocket of serine proteases. We have used steady-state and transient kinetic studies of the effects of varied pH and deuterium isotopic substitutions in substrates and solvent on the enzymatic rates to delineate catalytic consequences resulting from individual and combined replacements of the two asparagine residues by alanine. The rate constants for the overall hydride transfer to and from C-2 of mannitol, which were estimated as ~ 5×102 s−1 and ~ 1.5×103 s−1 in the wild-type enzyme respectively, were selectively slowed, between 540- and 2700-fold, in single-site mannitol 2-dehydrogenase mutants. These effects were additive in the corresponding doubly mutated enzyme, suggesting independent functioning of the two asparagine residues in catalysis. Partial disruption of the oxyanion hole in single-site mutants caused an upshift, by ≥1.2 pH units, in the kinetic pK of the catalytic acid-base Lys295 in the enzyme–NAD+–mannitol complex. The oxyanion hole of mannitol 2-dehydrogenase is suggested to drive a precatalytic conformational equilibrium at the ternary complex level in which the reactive group of the substrate is ‘activated’ for chemical conversion through its precise alignment with the unprotonated side chain of Lys295 (mannitol oxidation) and C=O bond polarization by the carboxamide moieties of Asn191 and Asn300 (fructose reduction). In the subsequent hydride transfer step, the two asparagine residues provide ~ 40 kJ/mol of electrostatic stabilization.
CTRP3/cartducin is induced by transforming growth factor‐β1 and promotes vascular smooth muscle cell proliferation
Authors: Maeda Takashi , Wakisaka Satoshi 
Published: November 2009

AbstractCTRP3 (C1q and tumour necrosis factor‐related protein 3)/cartducin, a novel serum protein, is a member of the CTRP superfamily. Although the CTRP3/cartducin gene is markedly up‐regulated in rat carotid arteries after balloon injury, little is known about its biological roles in arterial remodelling and neointima formation in injured blood vessels. We have investigated the mechanisms underlying CTRP3/cartducin up‐regulation and the in vitro effects of CTRP3/cartducin on vascular smooth muscle cells. CTRP3/cartducin expression in cultured p53LMAC01 vascular smooth muscle cells was induced by TGF‐β1 (transforming growth factor‐β1), but not by bFGF (basic fibroblast growth factor) or PDGF‐BB (platelet‐derived growth factor‐BB). Exogenous CTRP3/cartducin promoted the proliferation of p53LMAC01 cells in a dose‐dependent manner via ERK1/2 (extracellular signal‐regulated kinase 1/2)‐ and MAPK (p38 mitogen‐activated protein kinase)‐signalling pathways. In contrast, CTRP3/cartducin exhibited no effect on the migration of p53LMAC01 cells. Taken together, the results of the present study demonstrate a novel biological role of CTRP3/cartducin in promoting vascular smooth muscle cell proliferation in blood vessel walls after injury.
Early-life nutrition influences thymic growth in male mice that may be related to the regulation of longevity
Authors: Chen Jian-Hua , Tarry-Adkins Jane L. , Heppolette Chantal A.A. , Palmer Donald B. , Ozanne Susan E. 
Published: November 2009

Nutrition and growth rate during early life can influence later health and lifespan. We have demonstrated previously that low birthweight, resulting from maternal protein restriction during pregnancy followed by catch-up growth in rodents, was associated with shortened lifespan, whereas protein restriction and slow growth during lactation increased lifespan. The underlying mechanisms by which these differences arise are unknown. In the present study, we report that maternal protein restriction in mice influences thymic growth in early adult life. Offspring of dams fed a low-protein diet during lactation (PLP offspring) had significant thymic growth from 21 days to 12 weeks of age, whereas this was not observed in control mice or offspring of dams fed a low-protein diet during pregnancy (recuperated offspring). PCNA (proliferating-cell nuclear antigen) and SIRT1 (silent information regulator 1) protein levels at 21 days of age were significantly higher in the thymus from both PLP mice (P&lt;0.001 and P&lt;0.05 respectively) and recuperated mice (P&lt;0.001 and P&lt;0.01 respectively) compared with controls. At 12 weeks, PLP mice maintained a higher SIRT1 level, whereas PCNA was decreased in the thymus from recuperated offspring. This suggests that mitotic activity was initially enhanced in the thymus from both PLP and recuperated offspring, but remained sustained into adulthood only in PLP mice. The differential mitotic activity in the thymus from PLP and recuperated mice appeared to be influenced by changes in sex hormone concentrations and the expression of p53, p16, the androgen receptor, IL-7 (interleukin-7) and the IL-7 receptor. In conclusion, differential thymic growth may contribute to the regulation of longevity by maternal diet.
Quantitative Characterization of Polar Lipids from Wheat Whole Meal, Flour, and Starch
Authors: Finnie S. M. , Jeannotte R. , Faubion J. M. 
Published: November 2009

ABSTRACTLipids constitute only a minor proportion of total flour components but the composition and structure of wheat flour polar lipids influence the end‐use quality of bread. So it is important to determine which specific lipid class and molecular species are present in wheat. Lipid profiling is the targeted, systematic characterization and analysis of lipids. The use of lipid profiling techniques to analyze grain‐based food has the potential to provide new insight into the functional relationships between a specific lipid species and its functionality. The objective of this study was to utilize lipid profiling techniques to quantitatively determine the polar lipid species present in whole wheat meal, flour, and starch. Two commonly grown wheat cultivars, Alpowa and Overley, were used in this study. Direct infusion electrospray ionization tandem mass spectrometry was used to identify and quantitatively determine 146 polar lipid species in wheat. The predominant polar lipid classes were digalactosyldiglycerols, monogalactosyldiglycerols, phosphatidylcholine, and lysophosphatidylcholine. ANOVA results concluded that the wheat fraction contributed a greater source of variation than did cultivar on total polar, total phospholipid, and total galactolipid contents. Wheat whole meal, flour, and surface starch contained greater concentrations of total galactolipids, whereas internal starch lipids contained greater concentrations of monoacyl phospholipids. This research provides evidence that lipid profiling will provide the ability to determine the functional relationships between specific lipid species and the impact on end‐use quality.
Quantitative and Qualitative Role of Added Gluten on White Salted Noodles
Authors: Park Sei Joon , Baik Byung‐Kee 
Published: November 2009

ABSTRACTA commercial gluten and glutens isolated from four soft and four hard wheat flours were incorporated into a hard and a soft white flour by replacement to directly determine the quantitative and qualitative role of gluten proteins in making noodles. Gluten incorporation (6%) decreased water absorption of noodle dough by 3%, shortened the length of the dough sheet by 15 and 18%, and increased the thickness of the dough sheet by 18 and 20% in soft and hard wheat flour, respectively. Noodles imbibed less water and imbibed water more slowly during cooking with gluten incorporation, which resulted in a 3‐min increase in cooking time for both soft and hard wheat noodles. Despite the extended cooking time of 3 min, noodles incorporated with 6% gluten exhibited decreases in cooking loss by 15% in soft wheat. In hard wheat flour, cooking loss of noodles was lowest with 2% incorporation of gluten. Tensile strength of fresh and cooked noodles, as well as hardness of cooked noodles, increased linearly with increase in gluten incorporation, regardless of cooking time and storage time after cooking. While hardness of cooked noodles either increased or showed no changes during storage for 4 hr, tensile strength of noodles decreased. There were large variations in hardness and tensile strength of cooked noodles incorporated with glutens isolated from eight different flours. Noodles incorporated with soft wheat glutens exhibited greater hardness and tensile strength than noodles with hard wheat glutens. Tensile strength of cooked noodles incorporated with eight different glutens negatively correlated with SDS sedimentation volume of wheat flours from which the glutens were isolated.
Total Phenolics and Antioxidant Activity of Water and Ethanolic Extracts from Distillers Dried Grains with Solubles With or Without Microwave Irradiation
Authors: Inglett George E. , Rose Devin J. , Stevenson David G. , Chen Diejun , Biswas Atanu 
Published: November 2009

ABSTRACTThe purpose of this study was to determine the efficacy of extracting phenolic compounds with antioxidant activity from distillers' dried grains with solubles (DDGS) with water, 50% aqueous ethanol, and absolute ethanol, using microwave irradiation or a water bath at various temperatures. DDGS was extracted for 15 min with each solvent while heating at 23, 50, 100, and 150°C by microwave irradiation or in a water bath at 23, 50, and 100°C. Phenolic content of extracts increased with increasing temperature to a maximum of 12.02 mg/g in DDGS extracts that were microwave irradiated in water or with 50% aqueous ethanol at 150°C. Antioxidant activity range was 1.49–6.53 μmol of Trolox equivalents/g of DDGS. Highest antioxidant activities were obtained from 50% aqueous ethanol extracts at all temperatures, and water extracts that were heated at 100 and 150°C. These data indicate that DDGS extracts with high phenolic content and antioxidant activity can be obtained from DDGS, particularly with the use of water or 50% ethanol and high temperature (100 or 150°C). This may be valuable to ethanol manufacturers, livestock producers, and food and nutraceutical companies.