bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Molecular Mechanisms of Tobacco-Related Oral Carcinogenesis
Authors: Jiao Li  , Suharni Mohamad  , Rahman Nurhayu Ab 
Published: February 2025

Oral squamous cell carcinoma (OSCC) causes a serious loss of facial function or death, and its morbidity is highly related to the usage of tobacco products. Uncovering the mechanisms of tobacco-related OSCC plays a vital role in the prevention and treatment of OSCC. The present review systematically and comprehensively discusses the known mechanisms of tobacco-related OSCC and offer a foundation for the prevention, diagnosis, and treatment of tobacco-mediated OSCC. Scientific literature related to the incidence of tobacco-related OSCC and studies on mechanisms related to tobacco components are included, both in humans and animals. Among the 129 articles cited, three perspectives of the incidence of tobacco-related OSCC were evaluated: DNA adducts, receptor binding, and cocarcinogenic pathways. Tobacco-associated carcinogens cause OSCC by covalently binding to DNA to form DNA adducts or by binding to the receptors, and through the combined action of cocarcinogenic pathways. Three tobacco carcinogens that bind to DNA to form DNA adducts, two receptors that bind to carcinogens, five downstream pathways, and three cocarcinogen-related pathways were listed. This work evaluated the present research status of tobacco-related OSCC to enhance the pathogenesis knowledge of OSCC and offer a foundation for further research endeavours on the prevention, diagnosis, and treatment of tobacco mediated OSCC.
Gegevensbescherming in faillissement
Authors: van Staden ten Brink A. 
Published: February 2025

Gegevensbescherming in faillissement. Bespreking van het proefschrift van mr. M.D. Reijneveld
In dit artikel wordt het proefschrift van M.D. Reijneveld over gegevensbescherming in faillissement besproken. Reijneveld behandelt deze complexe materie op een toegankelijke wijze en gaat hierbij in op de vraagstukken die voor de faillissementspraktijk van belang zijn.
Pandbelening
Authors: Verheul E.F. 
Published: February 2025

Pandbelening. Bespreking van het proefschrift van mr. W. Ruijs
Het proefschrift van Ruijs analyseert de figuur van pandbelening zoals neergelegd in titel 7.2D BW. Deze recensie onderwerpt enkele centrale stellingen van het boek aan een kritische analyse.
O FALAR REGIONAL E A GAMIFICAÇÃO NO PROCESSO DE ENSINO E APRENDIZAGEM
Authors: Santana Amanda Silva , Rodrigues Carlos Eduardo Oliveira , Correa Hellen Giovanna dos Santos , Alves Camila Ferreira , Valerio Claudia Lucia Landgraf 
Published: February 2025

O falar cuiabano é parte do patrimônio histórico imaterial de Mato Grosso. Neste sentido, não podemos permitir que se apague da memória da população, uma vez que esse linguajar foi construído historicamente com a influência de várias outras línguas, como indígenas, espanhois e portugueses. Considerando a importância de se manter vivo este aspecto da cultura cuiabana, este trabalho, que atende a proposta do Projeto Integrador – Seu Espaço, Seu Povo e Sua Cultura (BNCC/ Temas transversais) do curso de Letras – UNIVAG, apresenta como objetivo contribuir com a valorização do patrimônio cultural, o falar cuiabano, fortalecendo a identidade regional, evidenciando seu espaço, seu povo e seus costumes. Além disso, procuramos promover atividades pedagógicas, em atendimento a BNCC, e de formação docente com base nas expressões do dialeto cuiabano. Para o desenvolvimento desta proposta pedagógica tivemos dois momentos: inicialmente em formação com os docentes sobre a temática proposta, tendo a gamificação como metodologia de ensino; em seguida atividade com os discentes. Pudemos constatar o interesse dos docentes tanto pelo falar cuiabano quanto por conhecer novas metodologias para o ensino. Verificamos, também, que os alunos pouco conheciam o falar cuiabano, mas após a atividade, além de poderem conhecer um pouco deste linguajar, ficaram curiosos para fazer novas descobertas. A resposta que tivemos para a atividade nos permite concluir que um fazer pedagógico, alinhado ao perfil atual dos educandos, pode contribuir para a construção de um conhecimento mais significativo e prazeroso.
Complexity Analysis of Pulse Oximeter Signals for Predicting Changes in Cardiorespiratory control system with Aging
Authors: Alharbi Naif , Alqahtani Mohammed 
Published: February 2025

The pulse oximeter signals have the potential to provide information about the functioning of the cardiorespiratory control system and its changing occurring due to aging and disease. The present study aimed to extract information on the system complexity of cardiorespiratory control system using pulse oximeter signals for predicting adverse health related events in elderly subjects. In this study we used complexity-based methods such as approximate entropy, sample entropy, permutation entropy, spectral entropy and singular value decomposition entropy to quantify the complex structure of pulse oximeter signals of young and elderly subject to decode age related changes in oxygen saturation. The dataset used in this study comprises of 36 healthy subjects, out of which 20 subjects are young and 16 are elderly. We use complexity-based methods such as approximate entropy, sample entropy, permutation entropy, spectral entropy and singular value decomposition entropy as feature sets and machine learning techniques including artificial neural networks, k-nearest neighbor, logistic Regression and random forest algorithms for developing prediction model. We used evaluation metrics true positive rate (TPR), false positive rate (FPR), precision, recall, F-Measure, and area under receiver operator characteristic curve (AUC) and total accuracy. The developed prediction model detects malfunction of cardiorespiratory control system in elderly subjects with an accuracy average of around 80%. The outcomes of the study can be helpful for clinicians for developing therapeutic interventions, and government for devising management strategies for those suffering from chronic obstructive pulmonary diseases and heart failure in elderly subjects.
DESENVOLVIMENTO DE PROCEDIMENTO OPERACIONAL PADRÃO PARA ESCRITURAÇÃO DE MEDICAMENTOS CONFORME PORTARIA SVS/MS 344/98.
Authors: Santos Denise Ramos Velozo dos , Ferraz Anderson Matheus Silva 
Published: February 2025

SUMMARY

This study addresses the responsibility of the Pharmacist in the management of controlled medications, according to Ordinance No. 344 of May 1998. The research setting is the Emergency Room of Jardim Jacira, located in Itapecerica da Serra-SP. The need to standardize handwritten records in the Satellite Pharmacy and the Hospital Pharmacy led to the creation of a Standard Operational Procedure (SOP). This work proposal emerges from the high turnover of Pharmacists in the institution, each following different methods. Consequently, there was no documented procedure for recording dispensations, losses, discrepancies, purchases, or any other legal activity related to these medications. The results of this research emphasize the importance of standardizing the processes for controlling controlled medications in healthcare units, contributing to operational efficiency and ensuring compliance with the regulations established by Ordinance No. 344/98. Furthermore, the documentation of this procedure complies with Good Pharmacy Practices defined by RDC No. 44/09, strengthening medication management in these institutions.

Keywords: control; standard operational procedure; pharmacy.
A IMPORTÂNCIA DA ALBUMINA NA CIRURGIA DE REVASCULARIZAÇÃO DO MIOCÁRDIO
Authors: Garcia Gracielle Alves , Martin Vera Lúcia Lino , Redon Rafaela Mourão 
Published: February 2025

ABSTRACT

This study aims to conduct a comprehensive literature review of medical studies investigating the use of albumin in coronary artery bypass grafting procedures. To this end, a careful analysis of scientific publications was conducted, including academic articles from national and international sources, in order to consolidate existing knowledge on the subject. The research aims to identify the most recent advances, as well as the clinical results related to the application of albumin in this specific context, highlighting its effects, benefits and possible limitations. With this, we seek to offer a solid theoretical basis that contributes to the improvement of medical practices and to the development of new studies on the use of this protein in highly complex cardiovascular procedures.

PALAVRAS CHAVES: Thoracic Surgery; Albumins; Myocardium
Phenology and Nutrient Studies of Rice (Oryza sativa L.) as Influenced by Different Crop Establishment Methods and Irrigation Scheduling
Authors: Nandini P. , Kumar K. Avil , Goverdhan M. , Neelima T. L. , K.Chandrasekar  , Prakash T. Ram 
Published: February 2025

The investigation on influence of different crop establishment methods and irrigation scheduling on phenology and nutrient studies of rice (Oryza sativa L.) was carried out in sandy clay soils at Agriculture Research Station, Kampasagar, Nalgonda district for two kharif seasons of 2021 & 2022. The experiment was laid out in split plot design with three main plots and 3 sub-plots replicated thrice. Phenological parameters like days to 50% flowering and maturity has a significant impact among establishment methods in which dry direct seeded rice with drum seeder (M1) recorded less number of days compared to manual transplanted puddled rice (M3). Total nitrogen, phosphorus and potassium content was non significantly increased with wet seeded rice with drum-seeder (M2) followed by manual transplanted puddled rice (M3) and dry direct seeded rice with seed drill (M1) method. Unlike that of nutrient content, uptakes have shown significant difference among establishment methods. However, irrigation scheduling treatments and interaction effect has found to be non-significant for both the years of study. In comparison with first year study, second year recorded higher values which may be due to better favourable condition that attributed better performance of crop.
A Primary Care–Based Weight Navigation Program
Authors: Griauzde Dina H. , Turner Cassie D. , Othman Amal , Oshman Lauren , Gabison Jonathan , Arizaca-Dileo Patricia K. , Walford Eric , Henderson James , Beckius Deena , Lee Joyce M. , Carter Eli W. , Dallas Chris , Herrera-Theut Kathyrn , Richardson Caroline R. , Kullgren Jeffrey T. , Piatt Gretchen , Heisler Michele , Kraftson Andrew 
Published: May 2024

ImportanceEvidence-based weight management treatments (WMTs) are underused; strategies are needed to increase WMT use and patients' weight loss.ObjectiveTo evaluate the association of a primary care–based weight navigation program (WNP) with WMT use and weight loss.Design, Setting, and ParticipantsThis cohort study comprised a retrospective evaluation of a quality improvement program conducted from October 1, 2020, to September 30, 2021. Data analysis was performed from August 2, 2022, to March 7, 2024. Adults with obesity and 1 or more weight-related condition from intervention and control sites in a large academic health system in the Midwestern US were propensity matched on sociodemographic and clinical factors.ExposureWNP, in which American Board of Obesity Medicine–certified primary care physicians offered weight-focused visits and guided patients’ selection of preference-sensitive WMTs.Main Outcomes and MeasuresPrimary outcomes were feasibility measures, including rates of referral to and engagement in the WNP. Secondary outcomes were mean weight loss, percentage of patients achieving 5% or more and 10% or more weight loss, referral to WMTs, and number of antiobesity medication prescriptions at 12 months.ResultsOf 264 patients, 181 (68.6%) were female and mean (SD) age was 49.5 (13.0) years; there were no significant differences in demographic characteristics between WNP patients (n = 132) and matched controls (n = 132). Of 1159 WNP-eligible patients, 219 (18.9%) were referred to the WNP and 132 (11.4%) completed a visit. In a difference-in-differences analysis, WNP patients lost 4.9 kg more than matched controls (95% CI, 2.11-7.76; P &amp;lt; .001), had 4.4% greater weight loss (95% CI, 2.2%-6.4%; P &amp;lt; .001), and were more likely to achieve 5% or more weight loss (odds ratio [OR], 2.90; 95% CI, 1.54-5.58); average marginal effects, 21.2%; 95% CI, 8.8%-33.6%) and 10% or more weight loss (OR, 7.19; 95% CI, 2.55-25.9; average marginal effects, 17.4%; 95% CI, 8.7%-26.2%). Patients in the WNP group were referred at higher rates to WMTs, including bariatric surgery (18.9% vs 9.1%; P = .02), a low-calorie meal replacement program (16.7% vs 3.8%; P &amp;lt; .001), and a Mediterranean-style diet and activity program (10.6% vs 1.5%; P = .002). There were no between-group differences in antiobesity medication prescribing.Conclusions and RelevanceThe findings of this cohort study suggest that WNP is feasible and associated with greater WMT use and weight loss than matched controls. The WNP warrants evaluation in a large-scale trial.
Socioeconomic Status Transition Throughout Life and Risk of Dementia
Authors: Sakaniwa Ryoto , Shirai Kokoro , Cadar Dorina , Saito Tami , Kondo Katsunori , Kawachi Ichiro , Steptoe Andrew , Iso Hiroyasu 
Published: May 2024

ImportanceSocioeconomic status (SES) is associated with dementia. However, the role of SES transitions in dementia is less explored; such evidence would be useful to understand whether social mobility is associated with healthy longevity at older ages.ObjectiveTo investigate the association of lifetime SES transition with risk of dementia.Design, Setting, and ParticipantsThis prospective cohort study, conducted from August 2010 to December 2016, used data from the Japan Gerontological Evaluation Study for participants aged 65 years or older from 31 different areas in Japan. Individuals with missing SES values, loss of follow-up, or new dementia onset 1 year or less from baseline were excluded. Data analysis was performed from April 2022 to April 2023.ExposureTransitions in SES across the life course.Main Outcomes and MeasuresThe main outcome was risk of dementia incidence and corresponding loss or gain of dementia-free periods in a lifespan. The incidence of dementia was identified with a national registry of long-term nursing care services.ResultsA total of 9186 participants (4703 men [51.2%]) were included. The mean (SD) age at baseline was 74.2 (6.0) years. Six SES transitions were identified: upward, stable-high, upper-middle, lower-middle, downward, and stable-low. During the follow-up period, 800 cases of dementia were identified. Many dementia risk factors, including lifestyle behaviors, comorbidities, and social factors, were associated with SES transition patterns. Compared with lower-middle SES, the lowest risk of dementia was observed for upward transition (hazard ratio [HR], 0.66; 95% CI, 0.57-0.74) followed by stable-high (HR, 0.77; 95% CI, 0.69-0.86), downward (HR, 1.15; 95% CI, 1.09-1.23), and stable-low (HR 1.45; 95% CI, 1.31-1.61) transition (P &amp;lt;  .001 for linearity); there was no association of upper-middle transition with risk of dementia (HR, 0.91; 95% CI, 0.79-1.03). The greatest increases in dementia-free years in the lifespan were also associated with upward SES transition (eg, 1.8 years [95% CI, 1.4-2.2 years] at age 65 years), while the downward transition was associated with the largest loss in lifetime dementia-free years at 75 years or older (eg, −1.4 years [95% CI, −2.4 to −0.4 years] at age 85 years).Conclusions and RelevanceThis cohort study of Japanese older adults identified that upward and downward SES transitions were associated with risk of dementia and the length of dementia-free periods over the lifespan. The results may be useful to understand the association between social mobility and healthy longevity.
β-Blocker Use and Clinical Outcomes in Patients With COPD Following Acute Myocardial Infarction
Authors: LaFon David C. , Helgeson Erika S. , Lindberg Sarah , Voelker Helen , Bhatt Surya P. , Casaburi Richard , Cassady Steven J. , Connett John , Criner Gerard J. , Hatipoglu Umur , Kaminsky David A. , Kunisaki Ken M. , Lazarus Stephen C. , McEvoy Charlene E. , Reed Robert M. , Sciurba Frank C. , Stringer William , Dransfield Mark T. 
Published: May 2024

ImportanceWhile β-blockers are associated with decreased mortality in cardiovascular disease (CVD), exacerbation-prone patients with chronic obstructive pulmonary disease (COPD) who received metoprolol in the Beta-Blockers for the Prevention of Acute Exacerbations of Chronic Obstructive Pulmonary Disease (BLOCK-COPD) trial experienced increased risk of exacerbations requiring hospitalization. However, the study excluded individuals with established indications for the drug, raising questions about the overall risk and benefit in patients with COPD following acute myocardial infarction (AMI).ObjectiveTo investigate whether β-blocker prescription at hospital discharge is associated with increased risk of mortality or adverse cardiopulmonary outcomes in patients with COPD and AMI.Design, Setting, and ParticipantsThis prospective, longitudinal cohort study with 6 months of follow-up enrolled patients aged 35 years or older with COPD who underwent cardiac catheterization for AMI at 18 BLOCK-COPD network hospitals in the US from June 2020 through May 2022.ExposurePrescription for any β-blocker at hospital discharge.Main Outcomes and MeasuresThe primary outcome was time to the composite outcome of death or all-cause hospitalization or revascularization. Secondary outcomes included death, hospitalization, or revascularization for CVD events, death or hospitalization for COPD or respiratory events, and treatment for COPD exacerbations.ResultsAmong 3531 patients who underwent cardiac catheterization for AMI, prevalence of COPD was 17.1% (95% CI, 15.8%-18.4%). Of 579 total patients with COPD and AMI, 502 (86.7%) were prescribed a β-blocker at discharge. Among the 562 patients with COPD included in the final analysis, median age was 70.0 years (range, 38.0-94.0 years) and 329 (58.5%) were male; 553 of the 579 patients (95.5%) had follow-up information. Among those discharged with β-blockers, there was no increased risk of the primary end point of all-cause mortality, revascularization, or hospitalization (hazard ratio [HR], 1.01; 95% CI, 0.66-1.54; P = .96) or of cardiovascular events (HR, 1.11; 95% CI, 0.65-1.92; P = .69), COPD-related or respiratory events (HR, 0.75; 95% CI, 0.34-1.66; P = .48), or treatment for COPD exacerbations (rate ratio, 1.01; 95% CI, 0.53-1.91; P = .98).Conclusions and RelevanceIn this cohort study, β-blocker prescription at hospital discharge was not associated with increased risk of adverse outcomes in patients with COPD and AMI. These findings support use of β-blockers in patients with COPD and recent AMI.
Proton‐Coupled Chemistry Enabled p–n Conjugated Bipolar Organic Electrode for High‐Performance Aqueous Symmetric Battery
Authors: Peng Chengxin , Wang Feixiang , Chen Qiang , Yan Xiaoli , Wu Chaoxin , Zhang Jiarui , Tang Wei , Chen Long , Wang Yonggang , Mao Jianfeng , Dou Shixue , Guo Zaiping 
Published: May 2024

AbstractBipolar‐type electrode materials are capable of improving the specific power and reducing the manufacturing costs for rechargeable symmetric batteries, while their development is plagued by the lack of reliable and affordable bipolar‐type materials. Here, a bipolar‐type indanthrene (IDT) with synergetic coupling effects of two redox centers of p‐type dihydrophenazines and n‐type anthraquinone in a single molecule is proposed to construct a symmetric battery. Due to the mutually affecting of n‐type and p‐type redox couples, the conjugated “p–n fusion” in the IDT material facilitates mutual electron cloud donation and withdrawal between two redox centers, thus a considerable output voltage of 0.62 V is realized in symmetric aqueous battery. Benefiting from its enriched redox centers and extended π‐conjugated structure, the symmetric battery also delivers a specific capacity of 139 mAh g−1 at 0.1 A g−1 and a long cycling stability with a capacity retention of 79% after 600 cycles at 2 A g−1. Comprehensive ex‐situ characterizations paired with density functional theroy calculations reveal both reversible HSO4− and H+ uptake/removal behavior during charging/discharging process. Additionally, a symmetric cell with quasi‐solid electrolyte is established, which exhibits superior practical application capability with a capacity retention of 78% at 2 A g−1 over 1000 cycles.
Advanced Enzyme Mimicking Engineering: 3D Biomimetic Pt Single‐Atom Nanozymes Initiating Pressure‐Driven Device
Authors: Chen Mengting , Qileng Aori , Chen Shizhang , Huang Haoliang , Xu Zhenlin , Liu Weipeng , Liu Yingju 
Published: May 2024

AbstractCurrent research on single‐atom nanozymes has predominantly concentrated on 2D structures, with limited exploration into the influence of 3D biomimetic structures on their catalytic performance. In this work, a 3D nanostructure of Pt single‐atom nanozyme (Pt‐NC SAzyme) is fabricated by encapsulating platinum 2,4‐pentanedionate in each molecular cage of ZIF‐8 and then pyrolyzing. X‐ray absorption fine structure analysis confirmed the presence of Pt as single atoms, with each Pt atom exclusively coordinated with four nitrogen atoms, while the *O is identified as an intermediate in the catalytic reaction. Additionally, theoretical calculations demonstrated that Pt‐NC SAzyme exhibited a lower potential energy and a shorter pathway for catalyzing the production of O2 from H2O2 than that of 2D Pt‐NC due to the localization effect, confirming a superior catalase‐like activity of Pt‐NC SAzyme. Based on the efficient O2 production from Pt‐NC SAzyme, a dual‐mode pressure immunosensor is established to achieve sensitive detection of aminopyrine by converting gas‐induced pressure into visual and timing readouts. This work introduced a novel approach to enhance the catalytic activity of SAzymes through bionic structural design and coordination environment, while also proposing a new concept for point‐of‐care testing in food safety, environmental monitoring, and disease diagnosis.
The Elaborate Design of Multi‐Polarization Effect by Non‐Edge Defect Strategy for Ultra‐Broad Microwave Absorption
Authors: Fang Gang , Liu Chuyang , Xu Meng , Zhang Xiaohan , Wu Yue , Kim Dong‐Hyun , Ji Guangbin 
Published: May 2024

AbstractAnion defect engineering is proven to be an efficient approach to reconstruct the electronic configuration of carbon‐based magnetoelectric materials for targeted modulation of electromagnetic (EM) performance. However, traditional mono‐anionic doping suffers from low defect concentration and lacks diverse polarization mechanisms. In this work, multi‐anions (N/S/F) stepwise‐doped carbon/Fe3C magnetoelectric composites are elaborately constructed, wherein the predesigned N defects serve as activated sites for anomalously adopting S anions (Step I) and subsequent F anions (Step II) in non‐marginal areas of the carbon layer. It is found that S prefers to replace pyrrolic N defects while F tends to form dangling bonds with the C site adjacent to the pyridinic N. Intriguingly, besides the inherent polarized resonance of N defect at ≈15 GHz, customized S and F defects induce new polarization resonances at ≈10 GHz and ≈15+ GHz, respectively. Under a typical multi‐polarization effect with the synergetic magnetic response, the carbon/Fe3C composites with N/S/F defects harvest the broadest bandwidth of 8.28 GHz (9.72–18 GHz) at 2.55 mm, covering a wide frequency range almost from X to Ku bands. This work demonstrates the positive impact of localized multi‐defects customization and multi‐polarization effect on expanding microwave absorption bandwidth, providing valuable insights for the advanced design of ultra‐broadband absorbers.