bluuebunny/crossref_metadata_2025_split huggingface dataset:
Still open research questions on technologies, microplastics, and antibiotic resistance
Authors: de Araújo J. C. , Santos H. A. , Vijande C. , Garrido J. M. , Tomei M. C. 
Published: May 2024

Abstract
In this final chapter, a summary of the still open questions to be solved for the scale-up of the technologies described in the previous chapters (including post-treatment options), for application in cold and temperate climate areas is provided. Special attention is dedicated to upflow anaerobic sludge blanket and anaerobic membrane bioreactors (AnMBRs), which are, even if with different peculiarities, the most promising solutions. In addition to anaerobic mainstream treatment technologies, recent research demand focuses also on two important emerging topics, which are of interest not only for anaerobic wastewater treatment, but also for conventional activated sludge plants, that is, the fate of microplastics (MPs) in plants and in receiving water bodies and the antibiotic resistance spreading. For these two topics, which were not analyzed in detail in the previous chapters, we propose in this chapter a general presentation of the state of knowledge in relation to wastewater treatment plants (WWTPs) with particular focus on anaerobic systems and related research needs. Concerning MPs, in spite they are recognized as ubiquitous pollutants, there is a strong research demand on the standardization of sampling and analytical protocols and on powerful technologies able to improve their removal. Even though information about the fate and effect of MPs in WWTPs with anaerobic treatments is scarce, AnMBRs have demonstrated high removal rates, which suggest them as a promising technology. As regard to antibiotic resistance, WWTPs are one of the main sources of dissemination of antibiotic-resistant bacteria (ARBs), antibiotic-resistant genes (ARGs), and antibiotic residues into the environment. Even if the available data are referring mainly to warm climate regions, it is worth noting that anaerobic reactors, alone or in combination with aerobic post-treatment, can remove from 0.5 to 3.0 log units of ARBs and ARGs depending on the resistance bacteria or gene. Also in this case AnMBRs achieved the best performance while good results have been also obtained with combined treatment options (i.e., anaerobic–aerobic and anaerobic post-treatment). Research demand on antibiotic resistance is driven by the need of clarifying the fate of ARBs, ARGs, antibiotics, pathogens in the treatment line, and the effects of wastewater characteristics on the plant performance. Important challenge is the development and evaluation of more effective disinfection and treatment methods (such as ultrafiltration and advanced oxidative processes) able to reduce the antibiotic resistance spreading from WWTPs.
Understanding Mechanisms and Key Factors Influencing Melanogenesis
for the Management of Melasma: An Updated Review
Authors: Singh Niraj Kumar , Verma Amnesh Kumar , Gupta Jeetendra Kumar 
Published: May 2024

Abstract:
Melanocytes are highly specialized dendritic cells that deliver melanin to keratinocytes in melanosomes, which are subcellular organelles where melanin is produced and stored.
Mammal’s skin, hair, and eyes all contain the complex pigment melanin, which gives them color
and ultraviolet protection. Melanins have the potential to be free radical sinks and are strong
cation chelators. Amino acid tyrosine and its metabolite, dopa, are the precursors to complex
metabolic processes that end with melanin production. Melanocytes generate different types and
amounts of melanin, which is defined genetically and is impacted by several extrinsic and intrinsic factors such as hormone fluctuations, inflammation, age, and ultraviolet radiation exposure,
leading to the stimulation of numerous melanogenesis pathways. Melasma, a common skin pigmentation condition, is associated with the overproduction of melanin and is characterized by
brown to gray-brown and black spots that mostly affect the face. The present review addresses
the regulatory mechanisms and signaling pathways involved in skin pigmentation with an emphasis on the altered melanogenesis that causes melasma and hyperpigmentation. The current
study also illustrates the available treatment options with cellular and molecular mechanisms for
the management of melasma. Understanding the mechanism of the pigmentation process may
help researchers develop new therapeutic strategies and novel drugs for the management of melasma.
Human Papillomavirus Genotype Distribution in a Hospital-based Single-center Study
Authors: Hashemi Seyedeh Razieh , Modarresi Farrokh , Esmailzadeh Arezoo , Sheikhsofla Nazanin Zeinab 
Published: May 2024

Background:
Cervical cancer is reported as one of the most prevalent malignancies
worldwide in women. There is a substantial connection between cervical diseases and infection
with Human Papillomavirus (HPV), especially Types 16 and 18 of HPV.

Objective:
This study aimed to assess the HPV genotype distribution to determine its most common
type at a referral hospital in Iran.

Methods:
This cross-sectional study was conducted on 400 women with positive HPV result tests
who visited the gynecologic oncology clinic of Baqiyatallah Hospital from 2017-2021.

Results:
The average age of subjects was 37.46±9.75 years (range=19-74). About 167 (41.8%) of
the patients were between 25 to 35 years. The analysis showed that 137 (34.2%) patients had only
low-risk (LR) typing, 129 (32.2%) patients had only high-risk (HR) typing, and 134 (33.5%) patients had both HR and LR typing. The most frequent LR HPV types were HPV 6 (18.5%) and 11
(17%), and the most frequent HR HPV types were HPV-16 (14.7%), 52 (8.2%), 18, and 31 (6.5%).

Conclusion:
This study showed that the most frequent age category in both low- and HR HPVpositive women is the age 25 to 35 years. The second most common HR-HPV subtypes included
HPV-52, not HPV-18, which indicates variations in HR-HPV subtypes in different populations and
races and warrants further research.
A Typology and Lead Isotope and Cultural Exchange Study on Bronze
Knives from Shuangyuan Cemetery, Chengdu City, Southwest China
Authors: Wang Xiaoting , Yang Yingdong , Wang Tianyou , Luo Wugan 
Published: May 2024

Background:
Bronze knives, which have been excavated in large quantities and acquired
hierarchical significance, are essential artifacts in Shu State in Southwest China. Building upon previous typological analyses of bronze knives, it is hypothesized that Shu culture may have imported
foreign-style bronze knives. However, further demonstration of the provenance of metal materials,
the typology of knives, and the cultural exchange necessitates a comprehensive examination through
the lens of scientific analysis. The purpose of this study is to investigate the differences in the manufacturing processes and metal resources of Shu bronze knives with various cultural styles and whether bronze knives in the foreign styles were imported or locally imitated.

Methods:
In this study, the typology, portable X-ray fluorescence spectrometry and multi-collector
inductively coupled plasma mass spectrometry were used to analyze twenty-four bronze knives unearthed from Shuangyuan cemetery, a cemetery of the Eastern Zhou Dynasty in Chengdu City, Sichuan Province, Southwest China.

Results:
The results of the study show that the knives of Shuangyuan Cemetery can be classified
typologically into five types, encompassing both local and foreign styles. The predominant alloy
composition of these knives is lead-tin bronze, characterized by a notably high tin content. Lead
isotope ratios indicate that metal materials from the South China geochemical province and Yangtze
geochemical province were mainly used to manufacture the bronze knives unearthed from the Shu
state

Conclusion:
While the majority of foreign-style knives with ring-shaped heads were likely imported
from neighboring regions like Chu state, distinctively styled type D and type E bronze knives appear
to have been locally imitated by the Shu, showcasing a blend of external influences and indigenous
innovation. The combination of typology and scientific analysis of the bronze knife may shed new
light on the study of the Shu culture of the Eastern Zhou period.
Fabrication and Characterization of Sustained-release Eudragit RSPO Microsphere of Lornoxicam by Spray Drying Technique
Authors: Patel Hiren V. , Ratnakar Nayan C. , Paliwal Himanshu , Prajapati Bhupendra G. 
Published: May 2024

Background:
Lornoxicam is a potent non-steroidal anti-inflammatory drug (NSAID) with
strong analgesic properties; however, its short half-life necessitates frequent administration for sustained
efficacy.

Objective:
The objective of the present study was to identify critical formulation parameters affecting
sustained release Eudragit RSPO microsphere of lornoxicam employing the concept of design of experiments.

Method:
The lornoxicam-loaded microspheres were prepared using a spray drying technique by optimizing
the drug:polymer ratio(X1) and inlet air temperature (X2) using a 32 full factorial design.
The percentage drug entrapment (Y1), percentage yield (Y2) and cumulative percentage of the drug
dissolved at 18 hr (Y3) were selected as dependent variables. Microspheres were evaluated for percentage
drug entrapment, mean particle size, percentage yield, in vitro drug release study and scanning
electron microscopy (SEM).

Result:
The optimized batch showed 84.51% drug release after 18 h with significantly higher drug
entrapment and percentage yield. The optimization was further verified using overlay and desirability
plots. The sustained release behavior of the drug from microspheres in GIT was displayed. The predicted
and observed responses for the optimized formulation were in close agreement with the release
profile of the drug.

Conclusion:
The sustained release microspheres of lornoxicam may prove to be an effective analgesic
with excellent anti-inflammatory potential.
HSLE: A Hybrid Ensemble Classifier for Prediction of Heart Disease
Authors: Kushwaha Pradeep Kumar , Dagur Arvind , Shukla Dhirendra 
Published: May 2024

Background:
Detecting heart disease in a timely manner is vital for preventing its progression, as it is the primary cause of death across the globe. Machine learning has the potential to
enhance diagnostic accuracy and enable better clinical decision-making. A machine learningpowered hybrid system for diagnosing heart disease may provide a better optimal solution for
heart disease prediction.

Objective:
The overarching objectives include accuracy improvement, enhanced classification
reliability, and the development of high-performance prediction models for heart disease. These
objectives indicate a commitment to advancing methodologies and models in the field of machine
learning and data science, particularly within the domain of healthcare and disease prediction.

Method:
The proposed system was developed using the Cleveland dataset that was preprocessed
and analyzed using Recursive Feature Elimination with Cross-Validation (RFECV) and Least Absolute Shrinkage and Selection Operator (LASSO) feature extraction techniques. Further, a hybrid
feature selection approach using RFECV and K-Best has been proposed for feature selection.
Eight machine learning classifiers such as Multilayer Perceptron (MLP), Random Forest (RF),
Extreme Gradient Boosting (XGB), K-Nearest Neighbours (KNN), Extra Tree (ET), Support Vector Machine (SVC), Adaboost, Decision Tree (DT) were utilized, and the performance of the system was measured in terms of various metrics.

Result:
The results showed that the proposed HSLE algorithm with hybrid feature selection led to
the highest overall accuracy of 98.76%.

Conclusion:
As mentioned, the main cause of adult death worldwide is chronic disease. Early detection can stop the condition from getting worse. Our research presents an innovative hybrid machine-learning approach designed to forecast heart disease.
Challenges and Needs in Digital Health Practice and Nursing Education Curricula: Gap Analysis Study
Authors: Livesay Karen , Walter Ruby , Petersen Sacha , Abdolkhani Robab , Zhao Lin , Butler-Henderson Kerryn 
Published: May 2024

Abstract

Background
Australian nursing programs aim to introduce students to digital health requirements for practice. However, innovation in digital health is more dynamic than education providers’ ability to respond. It is uncertain whether what is taught and demonstrated in nursing programs meets the needs and expectations of clinicians with regard to the capability of the nurse graduates.

Objective
This study aims to identify gaps in the National Nursing and Midwifery Digital Health Capability Framework , based on the perspectives of clinical nurses, and in nurse educators’ confidence and knowledge to teach. The findings will direct a future co-design process.

Methods
This study triangulated the findings from 2 studies of the Digital Awareness in Simulated Health project and the National Nursing and Midwifery Digital Capability Framework. The first was a qualitative study that considered the experiences of nurses with digital health technologies during the COVID-19 pandemic, and the second was a survey of nurse educators who identified their confidence and knowledge to teach and demonstrate digital health concepts.

Results
The results were categorized by and presented from the perspectives of nurse clinicians, nurse graduates, and nurse educators. Findings were listed against each of the framework capabilities, and omissions from the framework were identified. A series of statements and questions were formulated from the gap analysis to direct a future co-design process with nursing stakeholders to develop a digital health capability curriculum for nurse educators.

Conclusions
Further work to evaluate nursing digital health opportunities for nurse educators is indicated by the gaps identified in this study.
Analyzing Questions About Alcohol in Pregnancy Using Web-Based Forum Topics: Qualitative Content Analysis
Authors: Frennesson Nessie Felicia , Barnett Julie , Merouani Youssouf , Attwood Angela , Zuccolo Luisa , McQuire Cheryl 
Published: May 2024

Background
Prenatal alcohol exposure represents a substantial public health concern as it may lead to detrimental outcomes, including pregnancy complications and fetal alcohol spectrum disorder. Although UK national guidance recommends abstaining from alcohol if pregnant or planning a pregnancy, evidence suggests that confusion remains on this topic among members of the public, and little is known about what questions people have about consumption of alcohol in pregnancy outside of health care settings.

Objective
This study aims to assess what questions and topics are raised on alcohol in pregnancy on a web-based UK-based parenting forum and how these correspond to official public health guidelines with respect to 2 critical events: the implementation of the revised UK Chief Medical Officers’ (CMO) low-risk drinking guidelines (2016) and the first COVID-19 pandemic lockdown (2020).

Methods
All thread starts mentioning alcohol in the “Pregnancy” forum were collected from Mumsnet for the period 2002 to 2022 and analyzed using qualitative content analysis. Descriptive statistics were used to characterize the number and proportion of thread starts for each topic over the whole study period and for the periods corresponding to the change in CMO guidance and the COVID-19 pandemic.

Results
A total of 395 thread starts were analyzed, and key topics included “Asking for advice on whether it is safe to consume alcohol” or on “safe limits” and concerns about having consumed alcohol before being aware of a pregnancy. In addition, the Mumsnet thread starts included discussions and information seeking on “Research, guidelines, and official information about alcohol in pregnancy.” Topics discussed on Mumsnet regarding alcohol in pregnancy remained broadly similar between 2002 and 2022, although thread starts disclosing prenatal alcohol use were more common before the introduction of the revised CMO guidance than in later periods.

Conclusions
Web-based discussions within a UK parenting forum indicated that users were often unclear on guidance and risks associated with prenatal alcohol use and that they used this platform to seek information and reassurance from peers.
Peningkatan Kapasitas Usaha Konveksi Melalui Legalisasi Usaha dan Digital Marketing
Authors: Kurniawan Kukuh Dwi , Haryanti Agustin dwi , Sheng Soh Yong 
Published: May 2024

Purpose - MSMEs are business actors who support the economy in Indonesia. Even though they are small, a large number of business actors can produce a tremendous impact on the rotation of the economic wheel. However, it needs to be understood that not all business actors are successful, there are many obstacles that become problems for MSME business actors. For this reason, efforts need to be made to reduce the burden on MSME business actors, without having to wait for government efforts.
Design/methodology/approach – The implementation of this service took Dewi Collection partners who are engaged in the convection business located in Jodipan Village, Blimbing District, Malang City. This service consists of two activities carried out, namely, assistance in establishing a business entity in the form of a trading business and assistance in creating social media accounts as a means of digital marketing.
Findings - Community service activities increase the capacity of business actors and become influencers for other business actors for the same activities.
Originality/value - This treatment generally has positive implications for MSME business actors by increasing the business capacity of business actors.

KEYWORDS: Business entity; Convection Business, Digital Marketing; Legalization.
Impact of Atopic Dermatitis on Adult Women’s Lives: A Survey of 1,009 French Women
Authors: Fougerousse Anne Claire , Alexandre Marina , Darrigade Anne Sophie , Merhand Stéphanie , Marquié Adrien , Hamza Medhi , Le Fur Gaelle , Jachiet Marie , Bursztejn Anne Claire , Taieb Charles 
Published: May 2024

Atopic dermatitis (AD) is one of the most common inflammatory diseases, and has a higher prevalence among females in adulthood. The aim of this observational, cross-sectional, survey-based study was to evaluate the impact of AD on the daily lives of adult women patients. A scientific committee composed exclusively of women constructed a specific questionnaire in partnership with the French Eczema Association. Severity of AD was evaluated with the Patient-Oriented Eczema Measure (POEM). A sample of 1,009 adult women (mean age ± standard deviation: 41.8 ± 14.2 years) with AD was identified from a representative sample of the French population (82% response rate 1,230 women surveyed). According to the POEM, 50.64% (n = 511) of subjects were identified as having mild AD, 39.35% (n = 397) moderate AD, and 10.01% (n = 101) severe AD. Overall, 67.7% (n = 682) reported that their eczema involved a visible area (face, neck or hands), and 19.6% (n = 198) a sensual area (breasts/chest, genital area or buttocks). Of the 720 women with menstrual cycles, exacerbations of AD were reported to occur mostly before (50.6%) and during (48.3%) menstruation. A small proportion of women, 7.3% (n = 74), reported being afraid of becoming pregnant because of their eczema. If AD involvement was in a visible area it had a greater impact on romantic relationships, sexual relationships and occupation. If AD involvement was in a sensual area it had a greater influence on romantic relationships and sexuality. Particular attention should be given to patients with localization of AD on the face, neck or hands, as they have a higher risk of social exclusion. Moreover, these results should encourage health professionals to ask patients with AD about the possible involvement of sensual areas.
Relationship Between the Level of Knowledge of Covid-19 and The Movement Control Order (MCO) among Patients at Kinarut Health Clinic.
Authors: Baddiri Baidi , Abdullah Mohd Khairuddin , Musa Mazlinda , Mamat Rohani , Makajil Johari Daud , Duasin Clarice , Jelemie Caroline Satu 
Published: May 2024

The country has been facing the Covid-19 crisis that has affected the rest of the world in this decade. Numerous approaches and alternatives are implemented by the government to overcome this pandemic either controlled or stopped utterly. In order for the government to succeed, the emphasis on breaking the chain of infection of Covid-19 and the direction of the Movement Control Order (MCO) must be strengthened. Thus, the main goal of this study is to identify the level of patient’s knowledge regarding Covid-19 and Movement Control Order as well as to analyze the relationship between the level of knowledge about Covid-19 and Movement Control Order () among patients who come for treatment at the Kinarut Health clinic. Methodology: This study applies the quantitative research methodology, specifically surveys through questionnaires, whereas the sampling method used is systematic sampling with 200 patients in the Kinarut area. Analysis of instrument evaluation and sampling technique is also discussed in this study. Analysis: The finding showed that the patients' knowledge level about Covid-19 was at a moderate level with a mean value = 3.610, SD = 0.345. The level of knowledge relating to Movement Control Order (MCO) is also at a moderate level with a mean value = 3.610, SP = 0.345. Result: The correlation analysis showed that there is a strong relationship between the level of knowledge about Covid-19 and the level of knowledge of the Movement Control Order, with a correlation value of r = 0.71, p> 0.05. Thus, the results of this analysis show that there is a strong relationship between the variables of the knowledge level of Covid-19 and Movement Control Order in breaking the chain of infection Covid-19, particularly among patients who are living around Kinarut.
Las TIC en pandemia, desafíos y reinvención
Authors: Ramirez María Esperanza 
Published: May 2024

Reseña del Ebook “La aventura de innovar con TIC III: oportunidades y desigualdades en el marco de la pandemia” 2020, ediciones de la Facultad de Periodismo y Comunicación Social -Universidad Nacional de La Plata, este volumen cuenta con artículos sobre diversas prácticas virtuales, consecuencia del aislamiento generado por el COVID19, participaron comunicadores y docentes de distintos países y provincias, también se sumaron las voces de interlocutores de diferentes áreas por fuera del espacio académico. Como en las ediciones anteriores, se visibilizan una selección de los trabajos de las y los estudiantes del Seminario de Estrategias de Trabajo Colaborativo con Redes sociales virtuales y otros asistentes online, de la Facultad de Periodismo y Comunicación Social- UNLP.
Disponible para descarga gratuita en: https://bit.ly/34t7pzb