bluuebunny/crossref_metadata_2025_split huggingface dataset:
De la cohérence du style de rédaction avec le positionnement épistémologique du chercheur
Authors: Diné Sébastien 
Published: September 2011

Résumé Le style de rédaction n’est pas neutre, il traduit le positionnement épistémologique du chercheur. C’est en partant de ce postulat que je me suis interrogé sur la manière dont le style de rédaction du chercheur reflète implicitement une hypothèse sur la nature de la « réalité ». Cette question intéresse tout chercheur souhaitant mettre en adéquation l’articulation ontologie/épistémologie/méthodologie de sa recherche. Les travaux des linguistes et philosophes nous révèlent que certaines structures actuelles de notre langage postulent implicitement une « réalité » indépendante de son auteur. Dès lors, je proposerai dans cet article un style de rédaction tentant de rendre compte de la dépendance du chercheur à la « réalité » retranscrite, et contribuer ainsi aux conditions de réflexion d’un « foisonnement épistémologique ».
Comment étudier le matériau de gestion ? Propositions méthodologiques
Authors: Jardat Rémi 
Published: September 2011

Résumé La complexité des terrains qu’elles étudient amène les sciences de gestion à recourir à de nombreux emprunts transdisciplinaires. Il en résulte une ambiguïté quant à la pertinence et à la légitimité des productions académiques de gestion, face à laquelle un changement de période en matière d’écrits épistémologiques, mais aussi méthodologiques, s’avère nécessaire. Il est tout d’abord proposé ici de reformuler axiomatiquement l’objet comme l’objectif des sciences de gestion, sous l’angle de la représentation. Cet angle d’attaque, qui permet l’application de considérations structuralistes au sens large, amène à formuler plusieurs propositions d’ordre méthodologique visant à opérationnaliser en gestion les approches herméneutiques. Cinq jalons-clés de la démarche de recherche en gestion sont mis en avant, qui s’appuient pour partie sur le structuralisme des géologues : « élargir progressivement les cercles herméneutiques », « dé-plier les représentations de proche en proche », « repérer le front de schistosité », « redistribuer les représentations en un méga-pli unique » et enfin « repousser le front de schistosité ». Destinée à permettre au chercheur de croiser les disciplines tout en mesurant en quoi diffèrent ressemblances profondes d’une part et ressemblances superficielles d’autre part, une telle approche se veut tout aussi bien modulatrice que génératrice et régulatrice du travail scientifique.
Arterial Stiffness in Lower Limb Amputees
Authors: Magalhães Pedro , Capingana Daniel P. , Silva Amílcar B.T. , Capunge Inês R. , Gonçalves Mauer A.A. 
Published: September 2011

Background A high carotid-femoral pulse wave velocity (PWV) has been related to increased cardiovascular morbidity and mortality, but has not been previously evaluated in amputees. The aim of this study was to compare PWV between amputees and nonamputees. Methods In this cross-sectional study, data were collected from 60 male lower limb amputees and 86 male age-matched nonamputees. PWV was measured noninvasively using a Complior® device. All participants underwent laboratory investigations and anthropometry. The difference in PWV between amputee and nonamputees was estimated. Multivariate regression was used to adjust for differences between the groups as a result of potential confounders. Results PWV was higher in amputees than in nonamputees (10.8 ± 1.9 m/sec versus 9.9 ± 1.8 m/sec, P = 0.008, respectively). This difference remained even after adjusting for confounding factors. Conclusion A higher PWV was demonstrated in lower limb amputees. Routine assessment of PWV may contribute to cardiovascular risk stratification in amputees.
Continuous glucose monitoring and retinopathy of prematurity
Authors: Vanhaesebrouck Sophie , Vanhole Christine , Theyskens Claire , Casteels Ingele , Maleux Johan , Allegaert Karel , Naulaers Gunnar , Daniëls Hans , De Zegher Francis 
Published: September 2011

Purpose To use the continuous glucose monitoring system (CGMS) in very low birthweight (VLBW) infants to further explore the association between elevated glucose levels and retinopathy of prematurity (ROP) and to find new preventive strategies for ROP. Methods A secondary analysis of risk factors for ROP in VLBW infants was performed in the neonatal intensive care units of University Hospital Leuven and ZOL Genk, Belgium. The subjects were part of the NIRTURE trial (ISRCTN78428828). Only control subjects with conclusive ROP assessments who received standard clinical care were included in this analysis. A total of 100 VLBW infants (birthweight ≤ 1500 g) were included. Twenty-three (23%) infants developed ROP; 77 (77%) did not. Results Development of ROP was linked to the known classic risk factors. In addition, ROP was associated with higher glycemia levels across the first week (p between 0.01 and <0.0001). Across the first week, glycemia predicted ROP with receiver operating characteristic (ROC) scores between 0.67 and 0.80, and with a median glycemia cutoff of 6.7 mmol/L. Comparison of ROC curves revealed first-week glycemia as an important variable in the development of ROP with a predictive power as high as the classic risk factors. Conclusions Moderately elevated glucose levels in the first week of life are associated with the development of ROP. They contribute to this multifactorial disease in a way equal to the known classical risk factors for ROP. Therefore, careful monitoring of glucose levels by CGMS can be helpful in the prevention of ROP.
Susceptibility to exudative age-related macular degeneration and three genetic polymorphisms of glutathione S-transferase Z1 (GSTZ1)
Authors: Othman Hasan , Saadat Iraj , Farvardin-Jahromi Majid , Saadat Mostafa 
Published: September 2011

Purpose To investigate whether genetic polymorphisms of GSTZ1 contribute to the development of exudative age-related macular degeneration (AMD). Methods The present case-control study consisted of 112 patients (44 female, 68 male) with exudative AMD and 112 sex frequency-matched healthy controls were randomly selected from unrelated volunteers in the same clinic. Genotypes were determined by polymerase chain reaction–restriction fragment length polymorphism–based method. Results There was no significant association between study polymorphisms and susceptibility to exudative AMD. Considering the significant difference in age distribution between cases and controls, age was used as a covariate in further analysis. After odds ratio adjustment for age, the same results were observed. The study polymorphisms showed linkage disequilibrium. Analysis revealed that there was no difference between cases and controls for the prevalence of the haplotypes of GSTZ1. Conclusions Our study did not support any association between susceptibility to exudative AMD and polymorphisms of GSTZ1.
A história da súmula 331 do tribunal superior do trabalho: a alteração na forma de compreender a terceirização
Authors: Biavaschi Magda Barros , Droppa Alisson 
Published: September 2011

O texto, fundamentado em pesquisa realizada no Centro de Estudos Sindicais e de Economia do Trabalho do Instituto de Economia da UNICAMP, CESIT/IE/UNICAMP, analisa o processo de alteração do entendimento do Tribunal Superior do Trabalho, TST, quanto à terceirização que se expressou, em 1993, na revisão do Enunciado 256 pela Súmula 331, revisitada em 2000 para estender a responsabilidade subsidiária aos Entes Públicos que contratam terceiras. Para tanto, utilizaram-se: documentos e entrevistas, fontes que ofereceram elementos fundamentais à análise do papel da Justiça do Trabalho diante dessa forma de contratar e à discussão sobre seu potencial regulador das relações de trabalho.
Sodium Intake and Atopic Dermatitis
Authors: Chiang Brenda M. , Ye Morgan , Chattopadhyay Aheli , Halezeroglu Yagmur , Van Blarigan Erin L. , Abuabara Katrina 
Published: June 2024

ImportanceThe association of diet with atopic dermatitis (AD) remains poorly understood and could help explain heterogeneity in disease course.ObjectiveTo determine the extent to which a higher level of dietary sodium intake, estimated using urine sodium as a biomarker, is associated with AD in a large, population-based cohort.Design, Setting, and ParticipantsThis cross-sectional study of adult participants (aged 37-73 years) from the UK Biobank examined 24-hour urine sodium excretion, which was estimated using a single spot urine sample collected between March 31, 2006, and October 1, 2010, and calculations from the sex-specific International Cooperative Study on Salt, Other Factors, and Blood Pressure equation, incorporating body mass index; age; and urine concentrations of potassium, sodium, and creatinine. The data were analyzed between February 23, 2022, and March 20, 2024.ExposureThe primary exposure was 24-hour urinary sodium excretion.Main Outcome and MeasureThe primary outcome was AD or active AD based on diagnostic and prescription codes from linked electronic medical records. Multivariable logistic regression models adjusted for age, sex, race and ethnicity, Townsend Deprivation Index, and education were used to measure the association.ResultsThe analytic sample comprised 215 832 participants (mean [SD] age, 56.52 [8.06] years; 54.3% female). Mean (SD) estimated 24-hour urine sodium excretion was 3.01 (0.82) g per day, and 10 839 participants (5.0%) had a diagnosis of AD. Multivariable logistic regression revealed that a 1-g increase in estimated 24-hour urine sodium excretion was associated with increased odds of AD (adjusted odds ratio [AOR], 1.11; 95% CI, 1.07-1.14), increased odds of active AD (AOR, 1.16; 95% CI, 1.05-1.28), and increased odds of increasing severity of AD (AOR, 1.11; 95% CI, 1.07-1.15). In a validation cohort of 13 014 participants from the National Health and Nutrition Examination Survey, a 1 g per day higher dietary sodium intake estimated using dietary recall questionnaires was associated with a higher risk of current AD (AOR, 1.22; 95% CI, 1.01-1.47).Conclusions and RelevanceThese findings suggest that restriction of dietary sodium intake may be a cost-effective and low-risk intervention for AD.
Large Language Model Capabilities in Perioperative Risk Prediction and Prognostication
Authors: Chung Philip , Fong Christine T. , Walters Andrew M. , Aghaeepour Nima , Yetisgen Meliha , O’Reilly-Shah Vikas N. 
Published: June 2024

ImportanceGeneral-domain large language models may be able to perform risk stratification and predict postoperative outcome measures using a description of the procedure and a patient’s electronic health record notes.ObjectiveTo examine predictive performance on 8 different tasks: prediction of American Society of Anesthesiologists Physical Status (ASA-PS), hospital admission, intensive care unit (ICU) admission, unplanned admission, hospital mortality, postanesthesia care unit (PACU) phase 1 duration, hospital duration, and ICU duration.Design, Setting, and ParticipantsThis prognostic study included task-specific datasets constructed from 2 years of retrospective electronic health records data collected during routine clinical care. Case and note data were formatted into prompts and given to the large language model GPT-4 Turbo (OpenAI) to generate a prediction and explanation. The setting included a quaternary care center comprising 3 academic hospitals and affiliated clinics in a single metropolitan area. Patients who had a surgery or procedure with anesthesia and at least 1 clinician-written note filed in the electronic health record before surgery were included in the study. Data were analyzed from November to December 2023.ExposuresCompared original notes, note summaries, few-shot prompting, and chain-of-thought prompting strategies.Main Outcomes and MeasuresF1 score for binary and categorical outcomes. Mean absolute error for numerical duration outcomes.ResultsStudy results were measured on task-specific datasets, each with 1000 cases with the exception of unplanned admission, which had 949 cases, and hospital mortality, which had 576 cases. The best results for each task included an F1 score of 0.50 (95% CI, 0.47-0.53) for ASA-PS, 0.64 (95% CI, 0.61-0.67) for hospital admission, 0.81 (95% CI, 0.78-0.83) for ICU admission, 0.61 (95% CI, 0.58-0.64) for unplanned admission, and 0.86 (95% CI, 0.83-0.89) for hospital mortality prediction. Performance on duration prediction tasks was universally poor across all prompt strategies for which the large language model achieved a mean absolute error of 49 minutes (95% CI, 46-51 minutes) for PACU phase 1 duration, 4.5 days (95% CI, 4.2-5.0 days) for hospital duration, and 1.1 days (95% CI, 0.9-1.3 days) for ICU duration prediction.Conclusions and RelevanceCurrent general-domain large language models may assist clinicians in perioperative risk stratification on classification tasks but are inadequate for numerical duration predictions. Their ability to produce high-quality natural language explanations for the predictions may make them useful tools in clinical workflows and may be complementary to traditional risk prediction models.
Characterization of a novel TFG variant causing autosomal recessive pure hereditary spastic paraplegia
Authors: Hsiao Cheng‐Tsung , Tsai Tzu‐Yun , Shen Ting‐Yi , Tsai Yu‐Shuen , Liao Yi‐Chu , Lee Yi‐Chung , Tsai Pei‐Chien 
Published: June 2024

AbstractObjectiveTFG mutations have previously been implicated in autosomal recessive hereditary spastic paraplegia (HSP), also known as SPG57. This study aimed to investigate the clinical and molecular features of TFG mutations in a Taiwanese HSP cohort.MethodsGenetic analysis of TFG was conducted in 242 unrelated Taiwanese HSP patients using a targeted resequencing panel covering the entire coding regions of TFG. Functional assays were performed using an in vitro cell model to assess the impact of TFG variants on protein function. Additionally, other representative TFG mutant proteins were examined to understand the broader implications of TFG mutations in HSP.ResultsThe study identified a novel homozygous TFG c.177A>C (p.(Lys59Asn)) variant in a family with adolescent‐onset, pure form HSP. Functional analysis revealed that the Lys59Asn TFG variant, similar to other HSP‐associated TFG mutants, exhibited a low affinity between TFG monomers and abnormal assembly of TFG homo‐oligomers. These structural alterations led to aberrant intracellular distribution, compromising TFG's protein secretion function and resulting in decreased cellular viability.InterpretationThese findings confirm that the homozygous TFG c.177A>C (p.(Lys59Asn)) variant is a novel cause of SPG57. The study expands our understanding of the clinical and mutational spectrum of TFG‐associated diseases, highlighting the functional defects associated with this specific TFG variant. Overall, this research contributes to the broader comprehension of the genetic and molecular mechanisms underlying HSP.
Impact of Buried Interface Texture on Compositional Stratification and Ion Migration in Perovskite Solar Cells
Authors: Singh Shivam , Siliavka Elena , Löffler Markus , Vaynzof Yana 
Published: June 2024

AbstractDespite the striking increase in the power conversion efficiency (PCE) of lead‐based perovskite solar cells (PSCs), their poor operational stability impedes their commercialization. Among the various factors that influence device stability, ion migration has been identified as a key driver of degradation. In this work, the focus is on studying ion migration‐induced degradation in inverted architecture PSCs, which employ either a thin polymer layer or a self‐assembled monolayer (SAM) for hole extraction. It is demonstrated that the difference in texture imposed by the use of these hole transport layers (HTL) is an important and thus far inconspicuous factor that impacts ion migration, and consequently device stability. By investigating the buried interface in detail, it is revealed that its texture has a strong impact on the vertical compositional stratification in the perovskite active layer. By monitoring bias‐induced ion migration in devices with different hole extraction layers, it is demonstrated that the smooth polymer‐based HTL results in a higher degree of ion migration than the rough SAM HTL, corresponding to a stronger degradation in the former. These results further indicate that the use of SAMs for hole extraction is a promising strategy to suppress ion migration and improve device efficiency.
3D Domain Arrangement in van der Waals Ferroelectric α‐In2Se3
Authors: Lu Haidong , Masood Shehr Bano , Loes Michael , Acharya Khimananda , Hossain Md. Sazzad , Khurana Rashmeet K. , Bagheri Saman , Paudel Tula R. , Lipatov Alexey , Tsymbal Evgeny Y. , Sinitskii Alexander , Gruverman Alexei 
Published: June 2024

AbstractOne of the exceptional features of the van der Waals (vdW) ferroelectrics is the existence of stable polarization at a level of atomically thin monolayers. This ability to withstand a detrimental effect of the depolarization fields gives rise to complex domain configurations characterized, among others, by the presence of layered “antipolar” head‐to‐head (H‐H) or tail‐to‐tail (T‐T) dipole arrangements. In this study, tomographic piezoresponse force microscopy (TPFM) is employed to study the 3D polarization arrangement in vdW ferroelectric α‐In2Se3. Sequential removal of thin layers from the polar surface using the PFM tip reveals a complex 3D profile of the domain walls in the α‐In2Se3 crystals. Antiparallel domain layers stacked along the polar direction are also observed by PFM imaging of the non‐polar surfaces showing that H‐H and T‐T domain boundaries are commonly present in α‐In2Se3. Application of TPFM to the electrically written domains allows evaluation of their geometrical lateral‐to‐vertical size aspect ratio, which shows a strong prevalence for the sidewise expansion in comparison to the forward growth. Local I–V measurements reveal a strong polarization direction dependence of conductivity due to the modulation of the energy barrier height as corroborated by theoretical modeling.
Manipulating the Crystallization of Perovskite via Metal‐Free DABCO‐NH4Cl3 Addition for High Efficiency Solar Cells
Authors: Zhang Jing , Zheng Xinxin , Cui Qingyue , Yao Yuying , Su Hang , She Yutong , Zhu Yujie , Li Deng , Liu Shengzhong (Frank) 
Published: June 2024

AbstractThe performance of perovskite cells closely relies on the quality of films, leading to a special focus on crystallization manipulation and defect control. In this study, a novel approach using 1D metal‐free perovskites, specifically DABCO‐NH4Cl3, is proposed to facilitate the crystallization process of 3D FAPbI3 perovskites, while simultaneously addressing surface defects. Analysis of crystallization kinetics reveals that the introduction of 1D metal‐free perovskites provides numerous nucleation sites, effectively slowing down crystal growth rates and resulting in the formation of uniform, large‐grain perovskite films. Furthermore, the organic groups present in 1D perovskites play a crucial role in passivating defects within the perovskite structure. The synergistic impact of these factors enables the perovskite to achieve an efficiency of 24.72% while demonstrating exceptional stability. This research offers a promising approach for controlling perovskite crystallization, leading to the development of high‐efficiency and stable perovskite materials.
Ultrasensitive Monolithic Dopamine Microsensors Employing Vertically Aligned Carbon Nanofibers
Authors: Meng Lingju , Akhoundian Maedeh , Al Azawi Anas , Shoja Yalda , Chi Pei‐Yin , Meinander Kristoffer , Suihkonen Sami , Franssila Sami 
Published: June 2024

AbstractBrain‐on‐Chip devices, which facilitate on‐chip cultures of neurons to simulate brain functions, are receiving tremendous attention from both fundamental and clinical research. Consequently, microsensors are being developed to accomplish real‐time monitoring of neurotransmitters, which are the benchmarks for neuron network operation. Among these, electrochemical sensors have emerged as promising candidates for detecting a critical neurotransmitter, dopamine. However, current state‐of‐the‐art electrochemical dopamine sensors are suffering from issues like limited sensitivity and cumbersome fabrication. Here, a novel route in monolithically microfabricating vertically aligned carbon nanofiber electrochemical dopamine microsensors is reported with an anti‐blistering slow cooling process. Thanks to the microfabrication process, microsensors is created with complete insulation and large surface areas. The champion device shows extremely high sensitivity of 4.52× 104 µAµM−1·cm−2, which is two‐orders‐of‐magnitude higher than current devices, and a highly competitive limit of detection of 0.243 nM. These remarkable figures‐of‐merit will open new windows for applications such as electrochemical recording from a single neuron.
Click Chemistry‐Mediated Polymannose Surface‐Engineering of Natural Killer Cells for Immunotherapy of Triple‐Negative Breast Cancer
Authors: Niu Xiaomeng , Yang He , Guo Jiangping , Yao Lihua , Wang Yichen , Yu Wenzhuo , Liu Zhuang , Chen Hong 
Published: June 2024

AbstractNatural killer (NK) cells, serve as the frontline defense of the immune system, and are capable of surveilling and eliminating tumor cells. Their significance in tumor immunotherapy has garnered considerable attention in recent years. However, the absence of specific receptor–ligand interactions between NK cells and tumor cells hampers their selectivity, thereby limiting the therapeutic effectiveness of NK cell‐based tumor immunotherapy. Herein, this work constructs polymannose‐engineered NK (pM‐NK) cells via metabolic glycoengineering and copper‐free click chemistry. Polymannose containing dibenzocyclooctyne terminal groups (pM‐DBCO) is synthesized and covalently modified on the surface of azido‐labeled NK cells. Compared to the untreated NK cells, the interactions between pM‐NK cells and MDA‐MB‐231 cells, a breast tumor cell line with overexpression of mannose receptors (MRs), are significantly increased, and lead to significantly enhanced killing efficacy. Consequently, intravenous administration of pM‐NK cells will effectively inhibit the tumor growth and will prolong the survival of mice bearing MDA‐MB‐231 tumors. Thus, this work presents a novel strategy for tumor‐targeting NK cell‐based tumor immunotherapy.
Molecule Crowding Strategy in Polymer Electrolytes Inducing Stable Interfaces for All‐Solid‐State Lithium Batteries
Authors: Zhang Hong , Deng Jiahui , Xu Hantao , Xu Haoran , Xiao Zixin , Fei Fan , Peng Wei , Xu Lin , Cheng Yu , Liu Qin , Hu Guo‐Hua , Mai Liqiang 
Published: June 2024

AbstractAll‐solid‐state lithium batteries with polymer electrolytes suffer from electrolyte decomposition and lithium dendrites because of the unstable electrode/electrolyte interfaces. Herein, a molecule crowding strategy is proposed to modulate the Li+ coordinated structure, thus in situ constructing the stable interfaces. Since 15‐crown‐5 possesses superior compatibility with polymer and electrostatic repulsion for anion of lithium salt, the anions are forced to crowd into a Li+ coordinated structure to weaken the Li+ coordination with polymer and boost the Li+ transport. The coordinated anions prior decompose to form LiF‐rich, thin, and tough interfacial passivation layers for stabilizing the electrode/electrolyte interfaces. Thus, the symmetric Li–Li cell can stably operate over 4360 h, the LiFePO4||Li full battery presents 97.18% capacity retention in 700 cycles at 2 C, and the NCM811||Li full battery possesses the capacity retention of 83.17% after 300 cycles. The assembled pouch cell shows excellent flexibility (stand for folding over 2000 times) and stability (89.42% capacity retention after 400 cycles). This work provides a promising strategy to regulate interfacial chemistry by modulating the ion environment to accommodate the interfacial issues and will inspire more effective approaches to general interface issues for polymer electrolytes.