bluuebunny/crossref_metadata_2025_split huggingface dataset:
Virtuous Creativity: The Effects of Leader Behavioural Integrity on Follower Creative Thinking and Risk Taking
Authors: Palanski Michael E. , Vogelgesang Gretchen R. 
Published: November 2011

AbstractDespite the preponderance of research concerning creativity and ethical leadership, the possibility of why and how a leader's ethical behaviour may stimulate follower creativity has not been examined. Employing an online experimental design, we applied a virtue ethics framework to examine associations between subordinates' perceptions of their leader's integrity and their intention to think creatively and to engage in risk taking. Subordinates' perceptions of their leader's behavioural integrity positively predicted their sense of psychological safety. Moreover, psychological safety positively predicted followers' intention to think creatively and to take risks. Copyright © 2011 ASAC. Published by John Wiley & Sons, Ltd.
Epoxidation of Alkenes Catalyzed by Phenyl Group‐Modified, Periodic Mesoporous Organosilica‐Entrapped, Dimeric Manganese–Salen Complexes
Authors: Hu Jianglei , Wu Qingyin , Li Wei , Ma Ling , Su Fang , Guo Yihang , Qiu Yongqing 
Published: November 2011

AbstractA series of reusable, recoverable, diamine‐bridged dimeric manganese–salen complexes were prepared by the encapsulation of homogeneous dimeric Mn(salen) complexes into nanocages of a 3D periodic mesoporous organosilica (PMO) support followed by silylation of the support with organosilane. The composition, structure, morphology, and textural properties of the prepared PMO‐entrapped dimeric Mn(salen) complexes were characterized, and their catalytic performances were tested in the epoxidation of alkenes (styrene, cyclohexene, and 1‐phenylcyclohexene), with NaClO as an oxygen source and 4‐phenylpyridine‐N‐oxide as an axial ligand. Furthermore, the influences of the textural and morphological properties of the entrapped dimeric Mn(salen) complexes and the key reaction parameters on the catalytic activity and selectivity are discussed. Finally, the reusability of the supported dimeric Mn(salen) complexes was evaluated over three catalytic runs.
CMV drives clonal expansion of NKG2C+ NK cells expressing self‐specific KIRs in chronic hepatitis patients
Authors: Béziat Vivien , Dalgard Olav , Asselah Tarik , Halfon Philippe , Bedossa Pierre , Boudifa Ali , Hervier Baptiste , Theodorou Ioannis , Martinot Michelle , Debré Patrice , Björkström Niklas K. , Malmberg Karl‐Johan , Marcellin Patrick , Vieillard Vincent 
Published: November 2011

AbstractNatural killer (NK) cells are affected by infection with human cytomegalovirus (HCMV) manifested by increased expression of the HLA‐E binding activating receptor NKG2C. We here show that HCMV seropositivity was associated with a profound expansion of NKG2C+CD56dim NK cells in patients with chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection. Multi‐color flow cytometry revealed that the expanded NKG2C+CD56dim NK cells displayed a highly differentiated phenotype, expressed high amounts of granzyme B and exhibited polyfunctional responses (CD107a, IFN‐γ, and TNF‐α) to stimulation with antibody‐coated as well as HLA‐E expressing target cells but not when stimulated with IL‐12/IL‐18. More importantly, NKG2C+CD56dim NK cells had a clonal expression pattern of inhibitory killer cell immunoglobulin‐like receptors (KIRs) specific for self‐HLA class I molecules, with predominant usage of KIR2DL2/3. KIR engagement dampened NKG2C‐mediated activation suggesting that such biased expression of self‐specific KIRs may preserve self‐tolerance and limit immune‐pathology during viral infection. Together, these findings shed new light on how the human NK‐cell compartment adjusts to HCMV infection resulting in clonal expansion and differentiation of educated and polyfunctional NK cells.
Heterometallic Oximato‐Bridged Linear Trinuclear NiII−MIII−NiII (MIII = Mn, Fe, Tb) Complexes Constructed with the fac‐O3 [Ni(HL)3]– Metalloligand (H2L = pyrimidine‐2‐carboxamide oxime): A Theoretical and Experimental Magneto‐Structural Study (Eur. J. Inorg. Chem. 34/2011)
Authors: Kalogridis Cerise , Palacios María A. , Rodríguez‐Diéguez Antonio , Mota Antonio J. , Choquesillo‐Lazarte Duane , Brechin Euan K. , Colacio Enrique 
Published: November 2011

AbstractThe cover picture shows how oximate‐bridged heterometallic trinuclear NiIIMIIINiII complexes can easily be constructed from the assembly of the “in situ” generated fac‐O3 [Ni(HL)3]– (H2L = pyrimidine‐2‐carboxamide‐oxime) metalloligand (blue screw) with either M2+ ions (M2+ = Mn and Fe), which are oxidized during the course of the reaction, or Tb3+ ions (red nut). The nickel(II) ions in these centrosymmmetric trinuclear complexes exhibit opposite propeller‐like chirality (the blue screws turn on the red nut in opposite directions). The red and green arrows are the spins of the M3+ and Ni2+ ions, and they are antiparalell, which indicates that the interaction is antiferromagnetic in nature. Details are discussed in the article by E. Colacio et al. on p. 5225 ff.
Numerical multiscale methods
Authors: Coutinho A.L.G.A. , Franca L.P. , Valentin F. 
Published: November 2011

SUMMARYWe restrict the variational multiscale method to a class of methods we denote by numerical multiscale methods. Numerical multiscale methods are methods obtained by enriching the piecewise linear functions with special local functions. The enrichment provides additional stabilization via terms obtained by static condensation. The resulting methods are improvements of the coarse scale solutions by the approximations of the fine scales emanating from the enrichments.Copyright © 2011 John Wiley & Sons, Ltd.
Synthesis and Characterization of Polymer Blends of Sulfonated Polyethersulfone and Sulfonated Polyethersulfone Octylsulfonamide for PEMFC Applications
Authors: Mabrouk W. , Ogier L. , Vidal S. , Sollogoub C. , Matoussi F. , Dachraoui M. , Fauvarque J. F. 
Published: November 2011

AbstractOur goal in the present work was to synthesize a new proton exchange membrane that could be used in proton exchange membrane fuel cell (PEMFC), based on a blend of sulfonated polyethersulfone (S‐PES) and sulfonated polyethersulfone octylsulfonamide (S‐PESOS). Five blends, using S‐PESOS with different grafting ratios of sulfonamide groups, have been elaborated, characterized, and tested in a PEMFC. The similar chemical structure between these two polymers favored their compatibility. The synthesized membranes showed a high water swelling capacity and an ionic conductivity equivalent to that of Nafion® (0.1 S cm–1) in the same conditions.
S1P1 receptor subtype inhibits demyelination and regulates chemokine release in cerebellar slice cultures
Authors: Sheridan Graham K. , Dev Kumlesh K. 
Published: November 2011

AbstractSphingosine‐1‐phosphate receptors (S1PRs) are drug targets for the compound FTY720, which is the first oral therapy developed for treatment of relapsing‐remitting multiple sclerosis. S1PRs play a variety of functional roles in the differentiation, proliferation, survival and/or migration of neurons and glia. In this study, rat organotypic cerebellar slice cultures were used to assess whether S1PRs play a role in demyelination induced by lysolecithin (LPC). The data demonstrated that FTY720 and SEW2871 (a S1P1R‐specific agonist) inhibited LPC‐induced demyelination as assessed by myelin basic protein (MBP) immunofluorescence. Treatment with both drugs for 48 h also induced an increase in S1P1R expression in astrocytes. Moreover, FTY720 and SEW2871 inhibited the release of several chemokines in conditions of LPC‐induced demyelination, including LIX (CXCL5), MIP‐1alpha, and MIP‐3alpha. Taken together, the data suggest that activation of S1P1Rs prevents LPC‐induced demyelination via a mechanism involving a reduction of chemotactic chemokine release. The study supports the concept that FTY720 attenuates demyelination by not only preventing S1PR‐mediated T cell migration into the CNS but also by limiting cytokine communication between cells of the immune system and the CNS. © 2011 Wiley Periodicals, Inc.
International cross-cultural field validation of an European Organization for Research and Treatment of Cancer questionnaire module for patients with primary liver cancer, the European Organization for Research and Treatment of Cancer quality-of-life questionnaire HCC18
Authors: Chie Wei-Chu , Blazeby Jane M. , Hsiao Chin-Fu , Chiu Herng-Chia , Poon Ronnie T. , Mikoshiba Naoko , Al-Kadhimi Gillian , Heaton Nigel , Calara Jozer , Collins Peter , Caddick Katharine , Costantini Anna , Vilgrain Valerie , Trinquart Ludovic , Chiang Chieh 
Published: November 2011

Abstract

This international field validation study examined the psychometric properties and clinical validity of the European Organization for Research and Treatment of Cancer (EORTC) questionnaire module for hepatocellular carcinoma (HCC), the EORTC quality-of-life questionnaire (QLQ)-HCC18. The EORTC QLQ-HCC18 was administered with the core questionnaire, the EORTC QLQ-C30, to 272 patients from seven centers in 6 countries. Patient acceptability of the module was examined with a debriefing questionnaire, and psychometric and clinical properties were assessed. Multitrait scaling analyses confirmed the hypothesized scale structure without any scaling error, and the fatigue scale demonstrated satisfactory internal consistency. The test-retest reliability scores were high for all scales, except abdominal swelling and sexual interest. The correlations between all scales of the QLQ-HCC18 and the QLQ-C30 were low or moderate, and many scales could distinguish patients with different clinical conditions. The module demonstrated responsiveness to clinical change in pain before and after surgery and some borderline change in patients undergoing systemic treatment. Conclusion: The EORTC QLQ-HCC18 can be used as a supplementary module for the EORTC QLQ-C30 in clinical trials for patients with HCC. (Hepatology 2012)
Antagonistic effects of selenium and lipid peroxides on growth control in early hepatocellular carcinoma
Authors: Rohr-Udilova Nataliya , Sieghart Wolfgang , Eferl Robert , Stoiber Dagmar , Björkhem-Bergman Linda , Eriksson Lennart C. , Stolze Klaus , Hayden Hubert , Keppler Bernhard , Sagmeister Sandra , Grasl-Kraupp Bettina , Schulte-Hermann Rolf , Peck-Radosavljevic Markus 
Published: November 2011

Abstract

Activation of the activator protein 1 (AP-1) transcription factor as well as increased serum levels of vascular endothelial growth factor (VEGF) and interleukin (IL)-8 predict poor prognosis of patients with hepatocellular carcinomas (HCCs). Moreover, HCC patients display reduced selenium levels, which may cause lipid peroxidation and oxidative stress because selenium is an essential component of antioxidative glutathione peroxidases (GPx). We hypothesized that selenium-lipid peroxide antagonism controls the above prognostic markers and tumor growth. (1) In human HCC cell lines (HCC-1.2, HCC-3, and SNU398) linoleic acid peroxide (LOOH) and other prooxidants enhanced the expression of VEGF and IL-8. LOOH up-regulated AP-1 activation. Selenium inhibited these effects. This inhibition was mediated by glutathione peroxidase 4 (GPx4), which preferentially degrades lipid peroxides. Selenium enhanced GPx4 expression and total GPx activity, while knock-down of GPx4 by small interfering RNA (siRNA) increased VEGF, and IL-8 expression. (2) These results were confirmed in a rat hepatocarcinogenesis model. Selenium treatment during tumor promotion increased hepatic GPx4 expression and reduced the expression of VEGF and of the AP-1 component c-fos as well as nodule growth. (3) In HCC patients, increased levels of LOOH-related antibodies (LOOH-Ab) were found, suggesting enhanced LOOH formation. LOOH-Ab correlated with serum VEGF and IL-8 and with AP-1 activation in HCC tissue. In contrast, selenium inversely correlated with VEGF, IL-8, and HCC size (the latter only for tumors smaller than 3 cm). Conclusion: Reduced selenium levels result in accumulation of lipid peroxides. This leads to enhanced AP-1 activation and consequently to elevated expression of VEGF and IL-8, which accelerate the growth of HCC. Selenium supplementation could be considered for investigation as a strategy for chemoprevention or additional therapy of early HCC in patients with low selenium levels. (Hepatology 2012)
Increasing echogenicity of diffuse circumferential thickening (“macaroni sign”) of the carotid artery wall with decreasing inflammatory activity of takayasu arteritis
Authors: Keo Hong H. , Caliezi Gion , Baumgartner Iris , Diehm Nicolas , Willenberg Torsten 
Published: November 2011

AbstractWe report a case of sonographic follow‐up showing brightening of the diffuse circumferential thickening (halo) of the carotid artery wall (the so‐called “macaroni sign”) in a patient with decreasing inflammatory activity of Takayasu arteritis over a 6‐month period. Sonographic follow‐up in patients with Takayasu arteritis may be a useful complementary tool for evaluation of inflammatory activity. Besides a reduction of halo diameter, an increase in wall echogenicity appears to be a sign of decreasing inflammation. © 2011 Wiley Periodicals, Inc. J Clin Ultrasound 2013
Corneal gene delivery: chitosan oligomer as a carrier of CpG rich, CpG free or S/MAR plasmid DNA
Authors: Klausner Eytan A. , Zhang Zhong , Wong Suet P. , Chapman Robert L. , Volin Michael V. , Harbottle Richard P. 
Published: November 2011

AbstractBackgroundCorneal gene therapy can potentially treat acquired and inherited corneal disorders that otherwise lead to blindness. In a previous study on the development of effective vectors for corneal gene delivery, we showed that a particular formulation of chitosan‐DNA nanoparticles, based on ultrapure chitosan oligomers injected into rat corneas, led to transgene expression that was 5.4‐fold higher than that obtained using polyethylenimine‐DNA nanoparticles.MethodsIn the present study, we investigate the same formulation of chitosan‐DNA nanoparticles as carriers of six different plasmids for corneal gene delivery. Size, zeta potential, the ability to condense plasmid DNA, and transfection efficiency in cell cultures and in rat corneas, were all investigated.ResultsSize, zeta potential, the ability to condense plasmid DNA, and transfection efficiency in cell cultures did not substantially vary for nanoparticles based on different plasmids. One day post‐injection of nanoparticles into rat corneas, we found that a CpG‐free plasmid DNA, pCpG‐Luc, which has an EF1α promoter, led to transgene expression that was 7.1‐fold higher than that for gWiz‐Luc, a commercially available plasmid DNA with a cytomegalovirus (CMV) promoter used in our previous study; 116.8‐fold higher than that for pEPI‐CMV, a commercially available plasmid that has a scaffold/matrix attachment region (S/MAR) sequence and a CMV promoter; and 76.8‐fold higher than that for pEPI‐UbC, an experimental plasmid that has an S/MAR sequence and a ubiquitin C promoter.ConclusionsThe present study reveals the potential of comparing various plasmids as an approach for enhancing transgene expression. The delivery system designed in the present study represents the next step in the development of effective vectors for corneal gene therapy. Copyright © 2012 John Wiley & Sons, Ltd.
Preclinical validation of AR42, a novel histone deacetylase inhibitor, as treatment for vestibular schwannomas
Authors: Jacob Abraham , Oblinger Janet , Bush Matthew L. , Brendel Victoria , Santarelli Griffin , Chaudhury Abhik R. , Kulp Samuel , La Perle Krista M. D. , Chen Ching‐Shih , Chang Long‐Sheng , Welling D. Bradley 
Published: November 2011

AbstractObjectives/Hypothesis:Recent studies indicate that vestibular schwannomas (VSs) rely on phosphatidylinositol 3‐kinase/AKT activation to promote cell proliferation and survival; therefore, targeting AKT may provide new therapeutic options. We have previously shown that AR42, a novel histone deacetylase inhibitor, potently suppresses VS growth in vitro at doses correlating with AKT inactivation. The objectives of the current study were translational: 1) to examine the end biologic effects of AR42 on tumor growth in vivo, 2) to validate AKT as its in vivo molecular target, 3) to determine whether AR42 penetrates the blood‐brain barrier (BBB), and 4) to study the pharmacotoxicity profile of AR42.Study Design:In vivo mouse studies.Methods:AR42 was dosed orally in murine schwannoma allografts and human VS xenografts. Magnetic resonance imaging was used to quantify changes in tumor volume, and intracellular molecular targets were analyzed using immunohistochemistry. BBB penetration was assayed, and both blood‐chemistry measurements and histology studies were used to evaluate toxicity.Results:Growth of schwannoma implants was dramatically decreased by AR42 at doses correlating with AKT dephosphorylation, cell cycle arrest, and apoptosis. AR42 penetrated the BBB, and wild‐type mice fed AR42 for 6 months behaved normally and gained weight appropriately. Blood‐chemistry studies and organ histology performed after 3 and 6 months of AR42 treatment demonstrated no clinically significant abnormalities.Conclusions:AR42 suppresses schwannoma growth at doses correlating with AKT pathway inhibition. This orally bioavailable drug penetrates the BBB, is well tolerated, and represents a novel candidate for translation to human VS clinical trials.
A 1.2‐ to 3‐GHz tunable feedforward amplifier using broadband distributed phase shifters
Authors: Wu Shi , Xiao Jing , Cha Honnyong , Jo Sungjin , Kim Hongjoon 
Published: November 2011

AbstractIn this article, we demonstrate a broadband tunable feedforward amplifier design.For any frequency between 1.2 and 3 GHz, the third order intermodulation distortion (IMD) is reduced up to 18dB and the circuit maintains the spurious free dynamic range over 60 dBc at the output. This technique utilizes the combination of a broadband distributed‐element phase shifter (DPS) and a radio frequency feedforward approach to achieve a wideband linearization. The key element is a low‐loss, broadband and 360° changeable DPS. Because of its broadband tunable IMD cancellation capability, the proposed design will be very useful in multimode and multi channel wireless communication systems where the high power output with minimized distortion is needed. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:250–254, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26445
Antenna modeling using space‐mapping corrected cauchy approximation surrogates
Authors: Koziel Slawomir , Ogurtsov Stanislav , Bakr Mohamed H. 
Published: November 2011

AbstractIn this work, a computationally efficient antenna modeling technique. Our methodology is a two‐stage approach is present. In the first stage, a Cauchy‐based approximation model is constructed using coarsely discretized full‐wave simulation. The accuracy of this model is improved using a space mapping (SM) approach. A limited number of high‐fidelity antenna simulations are used in the SM phase. We show that our approach obtains a modeling accuracy comparable to that provided by direct Cauchy approximation of the high‐fidelity electromagnetic simulation data. The computational cost is, however, much lower. We successfully illustrate our approach through a number of antenna modeling examples. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:37–40, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26455
Circuital method for admittance calculation of gap‐coupled sectoral antennas
Authors: Kandwal Abhishek , Chakravarty Tapas , Khah Sunil Kumar 
Published: November 2011

AbstractA novel method for admittance calculation of two gap‐coupled sectoral patch antennas is described for wide band applications.Admittance is calculated both numerically and experimentally. The results of antenna are computed by the developed model and compared with the experimentally measured results of the designed antenna. The numerical results obtained are in good agreement with the experimental results. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:210–213, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26458
A highly‐birefringent fiber loop mirror temperature sensor demodulation based on a long‐period grating in photonic crystal fiber with differential processing
Authors: Wang Yunpeng , Zhao Chun‐Liu , Kang Juan , Jin Yongxing , Dong Xinyong 
Published: November 2011

AbstractA highly‐birefringent fiber loop mirror temperature sensor demodulation based on a long‐period grating (LPG) in photonic crystal fiber (PCF) with differential processing was proposed.Utilizing the property temperature insensitive and the filtering function of the LPG in PCF, the intensities of two signals located respectively within the positive and negative linear region of the LPG's transmission spectrum can be monitored simultaneously and accurately. The noise of fiber sensors is eliminated effectively by the algorithm of two signals, since the two signals (also including the noise of fiber sensors) transmit through the same way to the monitor. Experimental results show that the value of the algorithm remains constant when the power of light source varies ±10% and the relative error between the measured temperature change and the true change is only 0.34%. Compared with the sensing without the algorithm, the accuracy increases from∼97.3 to ∼99.7%. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:176–179, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26460
Spurline resonators design and its implementation to microwave oscillators
Authors: Shrestha Bhanu , Kim Nam Young 
Published: November 2011

AbstractIn this article, two compact L‐type spurline and symmetric meander spurline resonators were designed and implemented into low phase‐noise microwave oscillators for X‐band application. These resonators have a bandstop characteristic that can be used in the series feedback oscillator topology. Both of these miniaturized resonators are designed with different spurline structures, the first one being an L‐type spurline and the other one a meander spurline. Both resonators exhibited inherently inductive characteristics and had a loaded stub with capacitive characteristics. The oscillators using the spurline and the symmetric meander spurline resonators show excellent phase‐noise performances of −96.23 dBc/Hz and −104.39 dBc at a 100 kHz offset from the carrier frequency of 9.2 and 9.0 GHz with an output power of 12.47 and 16.42 dBm, respectively. The latter oscillator exhibited better phase‐noise characteristics due to the high Q value of the symmetric meander spurline resonator. The figure of merit of the first oscillator achieved −174, and the latter achieved −181.36. The size of the oscillator is reduced by constructing a parallel combination of the open stub at the source and the DC voltage supply at the drain © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:171–176, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26461
Broadband balun for monolithic microwave integrated circuit application
Authors: Yoo Hyoungsuk , Lee Se‐Hee , Kim Hongjoon 
Published: November 2011

AbstractWe present a compact and broadband balun based on the concept of a synthetic left‐handed transmission line and right‐handed transmission line.The compact balun uses lumped, discrete LC elements only to reduce the circuit size dramatically. For the frequency range of 0.6–1.2 GHz, this circuit maintains 180 ± 9.5° phase difference at the outputs, whereas the maximum insertion loss is −1.78 dB, and the minimum return loss is −10.2 dB at all three ports, yet the circuit size is merely 12 × 8 mm2. As far as we know, this is the smallest broadband balun reported in the literature, and the size can be further reduced, if the circuit is made with a monolithic microwave integrated circuit technology. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:203–206, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26468