bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of various volume syringes on solution delivery time using conventional irrigation technique in 0.04 tapered preparations of single straight root canals
Authors: Teja Kavalipurapu Venkata , Ramesh Sindhu , Choudhari Sahil , Özdemir Olcay , Janani Krishnamachari , Jose Jerry , Vasundhara Kaligotla Apoorva , Battineni Gopi 
Published: May 2024

Introduction:
The important aspect of endodontic treatment is root canal irrigation. Although agitation systems proved to have enhanced irrigant wall interactions, syringe needle-based delivery systems still play a significant role during the preparatory phases of root canal treatment. The current study aimed to evaluate the time taken for the irrigant delivery during conventional syringe irrigation using different volume syringes in different root canal preparations.

Materials and Methods:
Two hundred extracted single-rooted premolars with approximately round canals were randomly instrumented to preferred apical preparation sizes using 0.4 tapered Hyflex-CM rotary Ni-Ti instruments and randomly divided as follows: Group I, instrumentation to size 40, 0.04 taper (n = 50); Group II, instrumentation to size 30, 0.04 taper (n = 50); Group III, instrumentation to size 25, 0.04 taper (n = 50); and Group IV, instrumentation to size 20, 0.04 taper (n = 50). Fifty operators were chosen for the experimentation. They were asked to irrigate the prepared specimens using different volume syringes. The entire irrigant delivery time was recorded by a head nurse using a stopwatch, and the values were calibrated and statistically analyzed.

Results:
Group I recorded significantly lesser time for irrigant delivery during manual syringe needle irrigation (P = 0.005) compared to other groups.

Conclusion:
Irrigation delivery time was less in 40/0.04 taper preparations, using 1 ml volume syringes.
Influence of technical quality and coronal restoration on periapical health of root canal treatment performed by Malaysian undergraduate students
Authors: Mohammad Norazlina , Fatah Faizah Abdul , Jaafar Azlan , Omar Siti Hajar , Ahmad Aimi Amalina , Abdul Aziz Abdul Azim Asy , Al-Kadhim Aws Hashim Ali 
Published: May 2024

Introduction:
Root canal treatment (RCT) and its coronal restoration should be regularly assessed to ensure a successful treatment outcome. The aim of the current study is to evaluate the relationship between the obturation technical quality and coronal restoration in the clinical and radiographic outcome of RCT provided by Malaysian undergraduate students.

Materials and Methods:
A total of 143 root-treated teeth from 136 patients were evaluated through clinical examinations and periapical radiographs with a mean follow-up period of 2.4 (standard deviation = 1.59) years. The quality of the coronal restoration was classified according to modified United States Public Health Service criteria and the technical quality of the obturation was assessed based on two variables: length and density. Periapical status was evaluated according to periapical index scores.

Results:
About 64% of the teeth were classified as healthy with a significant reduction of apical periodontitis from 70.3% preoperatively to 36% at reassessment (P < 0.001). About 92.1% of obturation was of acceptable length, whereas 5% underfilled and 2.9% overfilled. Teeth with acceptable obturation length were five times less likely associated with apical periodontitis than the inadequately filled ones. 90% of canals had adequate obturation density with no significant association to apical periodontitis. Teeth restored with intracoronal restorations had 50% more chance of developing apical periodontitis. Inadequately restored teeth and teeth with poor obturation quality were associated with three times more likely apical periodontitis occurrence. The quality of endodontic treatment and the coronal restoration significantly influenced the periapical status (P < 0.001).

Conclusion:
The radiographic obturation quality and coronal restorations of the RCTs performed by the undergraduate students in a Malaysian public dental school were acceptable in 63.8% of cases with a 64% favorable outcome.
Dental health status in Chennai corporation schools – An evaluative and comparative study
Authors: Gamal Abdul Nasser K. S. , Rupkumar P. , Narayan Madhu 
Published: May 2024

Background:
Schools in Chennai are run publicly by the government or run privately, some with financial aid from the government in Tamil Nadu, a southern state of India. There are various systems of education – CBSE, Anglo Indian Board, ICSE Board, NIOS Board, Matriculation, Montessori, and State Board. From these, a massive study was conducted among 100,620 corporation school (state-run) students in the district of Chennai to find the prevalence of various dental diseases among them.

Aim:
To evaluate and compare the prevalence of various dental diseases among the corporation school children from different zones of Chennai city.

Materials and Methods:
The study was carried out for a period of about 15 months. It involved diagnosis, therapeutics, and referral to the state-run dental hospital for further follow-up. The district of Chennai was divided into ten zones. The school students, zone-wise, were screened, diagnosed and the required treatments were done at the venue or were referred to the higher center for further examination or treatment. The data collected were divided into zone-wise categories on the basis of disease occurrence and treatment/referral done and were tabulated.

Results:
The result obtained was that an astounding 74.36% of corporation school students were afflicted with some form of dental disease.

Conclusion:
Various associated factors such as lower socioeconomic status of the parents, educational background of the parents, dental education, and awareness among the school students could play major roles in the status of dental health among the corporation school children.
Extracellular vesicles: Function, resilience, biomarker, bioengineering, and clinical implications
Authors: Sun Der-Shan , Chang Hsin-Hou 
Published: May 2024

ABSTRACTExtracellular vesicles (EVs) have emerged as key players in intercellular communication, disease pathology, and therapeutic innovation. Initially overlooked as cellular debris, EVs are now recognized as vital mediators of cell-to-cell communication, ferrying a cargo of proteins, nucleic acids, and lipids, providing cellular resilience in response to stresses. This review provides a comprehensive overview of EVs, focusing on their role as biomarkers in disease diagnosis, their functional significance in physiological and pathological processes, and the potential of bioengineering for therapeutic applications. EVs offer a promising avenue for noninvasive disease diagnosis and monitoring, reflecting the physiological state of originating cells. Their diagnostic potential spans a spectrum of diseases, including cancer, cardiovascular disorders, neurodegenerative diseases, and infectious diseases. Moreover, their presence in bodily fluids such as blood, urine, and cerebrospinal fluid enhances their diagnostic utility, presenting advantages over traditional methods. Beyond diagnostics, EVs mediate crucial roles in intercellular communication, facilitating the transfer of bioactive molecules between cells. This communication modulates various physiological processes such as tissue regeneration, immune modulation, and neuronal communication. Dysregulation of EV-mediated communication is implicated in diseases such as cancer, immune disorders, and neurodegenerative diseases, highlighting their therapeutic potential. Bioengineering techniques offer avenues for manipulating EVs for therapeutic applications, from isolation and purification to engineering cargo and targeted delivery systems. These approaches hold promise for developing novel therapeutics tailored to specific diseases, revolutionizing personalized medicine. However, challenges such as standardization, scalability, and regulatory approval need addressing for successful clinical translation. Overall, EVs represent a dynamic frontier in biomedical research with vast potential for diagnostics, therapeutics, and personalized medicine.
Análisis de la percepción funcional y calidad de vida en pacientes que viven con esclerosis sistémica
Authors: Pérez Pérez Cornelio 
Published: May 2024

PROBLEMA: existe relación significativa entre la percepción de la funcionalidad y la calidad de vida en pacientes con esclerosis sistémica desde su propia perspectiva. OBJETIVO: analizar la percepción funcional y calidad de vida en pacientes que viven con Esclerosis Sistémica. MÉTODO: el método utilizado en la presente investigación es el método hipotético deductivo, muestreo de bola de nieve, con resultados cuantitativos por medio de las pruebas SySQ y SF-36. RESULTADOS: el 37% de la población muestra que si tiene dificultad leve, mientras que un 9% presenta dificultades graves en sus habilidades motoras, así mismo a un 3% de la población con esclerosis sistémica les resulta imposible realizar algunas actividades básicas de la vida cotidiana y al menos el 25% ha señalado vulnerabilidad emocional, mientras que un 45% dice que algunas veces ha presentado quebrantos emocionales, mencionado también que por lo menos el 16% tiene problemas del sueño-vigilia, y un 8% por ciento ha indicado también que tiene problemas de memoria. CONCLUSIÓN: las personas que padecen esclerodermia no solamente resultan con deterioro en la funcionalidad general, es decir discapacidad progresiva, sino también aunado al deterioro físico se suma el deterioro cognitivo y mental.
Nivel de conocimiento sobre los hitos del neurodesarrollo en estudiantes de Psicología: Estudio de casos
Authors: Cuguá López Sandra Nineth 
Published: May 2024

PROBLEMA: los hitos del desarrollo constituyen habilidades marcadas en el proceso evolutivo del niño y permiten conocer las condiciones bajo las cuales se produce el desarrollo infantil. Este artículo se enfocó en estudiar la importancia del conocimiento de los hitos del desarrollo que deben poseer los estudiantes de Psicología al desempeñarse en el servicio de atención y orientación especializada a niños y padres de familia. OBJETIVO: analizar el nivel de conocimientos sobre los hitos del neurodesarrollo en los estudiantes de Psicología, para demostrar la importancia de las etapas del crecimiento y la identificación precoz en los retrasos en el desarrollo. MÉTODO: se utilizó un enfoque metodológico de estudio de casos, cuantitativo y diseño no experimental transversal, con un alcance de estudio descriptivo. La muestra fue de 10 estudiantes universitarios cuyo promedio de edad estuvo entre los 18 a 45 años. RESULTADOS: el estudio reportó conocimientos escasos sobre los hitos del desarrollo, por lo que se debe promover que los estudiantes de Psicología se apropien de mayor conocimiento sobre aspectos del desarrollo Infantil. CONCLUSIONES: los hitos del desarrollo son indicadores importantes del crecimiento y evolución de un niño, por lo que obtener conocimiento sobre los hitos principales del desarrollo es fundamental y básico en la formación de todo profesional de la salud, que brinda orientación y apoyo a todos los usuarios que requieren potencializar sus habilidades.
EVALUASI PENGGUNAAN OBAT ANTIDIABETES PADA PASIEN DIABETES MELLITUS DAN TERDAPAT HIPERTENSI DI RUMAH SAKIT UIN SYARIF HIDAYATULLAH
Authors: Aripin Aripin , Ismaya Nurwulan Adi , Pratiwi Rita Dwi , Indah Fenita Purnama Sari , Azzahra Elsa 
Published: May 2024

Diabetes mellitus (DM) is a degenerative disease characterized by an increase in blood glucose levels above the normal threshold with clinical manifestations in the form of polyphagia, polydipsia and polyuria. Diabetes mellitus (DM) is currently one of the global health threats. This research aim to determine the Evaluation of Antidiabetic Drug Use in Diabetes Patients with Hypertension Complications at Syarif Hidayatullah Hospital in 2022. This research using descriptive retrospective. Data collection using the total sampling technique method with a sample size of 91 patients in 2022 at Syarif Hidayatullah Hospital. Based on the results of the study, it shows that the most age is 46-65 years old as many as 64 patients (70%). Patient characteristics based on gender are mostly female with 46 patients (51%). The use of the most drugs is metformin group with biguanid group as many as 12 patients (13%). The percentage of rationality includes the right diagnosis (100%), the right indication (100%), the right drug (100%), the right dose (95%), the right method of administration (89%), the right time interval for administration (95%), the right duration of administration (95%), the right patient (100%). Potential drug interactions were 31 patients (34%) who had potential drug interactions. Based on the results of this study, it can be concluded that the evaluation of drug use at Syarif Hidayatullah Hospital is rational.Abstrak Diabetes mellitus (DM) saat ini menjadi salah satu ancaman kesehatan global. Prevalensi pasien DM terbesar adalah DM dengan komplikasi Hipertensi, Lebih dari 50% penderita DM tipe 2 mengalami hipertensi. Tujuan penelitian ini adalah untuk mengetahui Evaluasi Penggunaan Obat Antidiabetes Pada Pasien Diabetes Komplikasi Hipertensi di Rumah Sakit Syarif Hidayatullah tahun 2022. Penelitian ini menggunakan deskriptif secara retrospektif. Pengumpulan data menggunakan metode teknik total sampling dengan jumlah sampel sebanyak 91 pasien pada tahun 2022 di Rumah Sakit Syarif Hidayatullah. Berdasarkan hasil penelitian menunjukkan usia terbanyak yaitu 46-65 tahun sebanyak 64 pasien (70%). Karakteristik pasien berdasarkan jeis kelamin terbanyak yaitu perempuan dengan jumlah 46 pasien (51%). Penggunaan obat terbanyak yaitu golongan metformin dengan golongan biguanid sebanyak 12 pasien (13%). Persentase kerasionalan meliputi tepat dignosis (100%), tepat indikasi (100%), tepat obat (100%), tepat dosis (95%), tepat cara pemberian (89%), tepat interval waktu pemberian (95%), tepat lama pemberian (95%), tepat pasien (100%). Potensi interaksi obat sebanyak 31 pasien (34%) yang memiliki potensi interaksi obat. Berdasarkan hasil penelitian ini, dapat diperoleh kesimpulan bahwa evaluasi penggunaan obat di RS Syarif Hidayatullah sudah rasional.
GRAVIDEZ NA ADOLESCÊNCIA: DESAFIOS DA GRAVIDEZ EM PACIENTES COM HIV E AIDS
Authors: Silva Dayane Falcão da , Costa Vitória Cristine Alves da , Moura Blenda Evangelista de 
Published: May 2024

A gravidez na adolescência é uma realidade complexa e desafiadora que traz consigo uma série de preocupações e riscos adicionais, especialmente quando a jovem portadora do vírus HIV ou AIDS encontra-se nesta fase crucial de desenvolvimento. Trata-se de estudo de revisão integrativa da literatura, com procedimento descritivo e comparativo, utilizando como fonte de dados a bibliografia que descreva: A gravidez na adolescência e os desafios da gravidez em pacientes com HIV/AIDS. O estudo foi realizado por meio da pesquisa nas bases de dados como Biblioteca virtual em saúde (BVS) e SCI’ELO (Scientific Eletronic Libray Online), As consequências da gravidez na adolescência são diversas e impactam tanto as jovens mães quanto seus filhos, as adolescentes grávidas enfrentam desafios físicos, emocionais e sociais, incluindo maior risco de complicações durante a gestação. Somente através de uma abordagem abrangente e colaborativa, podemos garantir que essas jovens tenham acesso aos cuidados e apoio necessários para uma gestação saudável e segura, promovendo assim o bem-estar tanto da mãe quanto do bebê.
A fé como estratégia de enfrentamento ao câncer
Authors: Nunes Yara Martins , Fortes Renata Costa 
Published: May 2024

As crenças espirituais podem influenciar a maneira como os indivíduos enfrentam as doenças, com impacto positivo na redução de sintomas físicos e emocionais. O objetivo deste estudo foi avaliar a influência da fé e da espiritualidade como estratégias de enfrentamento ao câncer. Estudo transversal descritivo realizado em um hospital público do Distrito Federal. Amostra de 30 pacientes com diversos tipos de câncer em tratamento quimioterápico. Os dados foram coletados por meio de entrevista semiestruturada e Escala de Coping Religioso-Espiritual (Escala CRE), primeiro instrumento de avaliação de CRE do Brasil, com base na escala norte-americana RCOPE de Pargament, Koenig e Perez (2000). Verificou-se relevante influência da religiosidade/espiritualidade no enfrentamento ao câncer e intensificação da fé após serem diagnosticados com a doença. Constatou-se que, subsequente ao diagnóstico, as pessoas procuram mais a religiosidade/espiritualidade, revendo valores e transformando-se para melhor enfrentamento do adoecimento.
Reflexões sobre uma proposta de didática semiótica e suas contribuições para o ensino
Authors: Borges Aline de Gregorio Alves , Pinho Aparecida Maria Xenofonte de 
Published: May 2024

Este artigo levanta questionamentos sobre as menções ao termo “análise semiótica” constantes na redação do texto da Base Nacional Comum Curricular (BNCC). O documento, que tem por objetivo orientar e normatizar as redes de ensino públicas e privadas, nos níveis fundamental e médio, utiliza em diversos trechos do Manual para área de Linguagens e seus Códigos, a expressão, entretanto, sem nenhuma indicação sobre a fundamentação teórica em que se alicerça. Uma das possibilidades de adoção teórico- metodológica, seria a da teoria Semiótica Discursiva, de origem francesa, cujo arcabouço foi delineado pelo linguista lituano Algirdas Julien Greimas (1917-1992) por meio do percurso gerativo de sentido (PGS). Para Diana Barros (1990), o percurso procura descrever e explicar o que o texto diz e como ele faz para dizer o que diz. Ocupa-se, portanto, do sentido do texto pelo exame do seu plano de conteúdo. Para além do PGS, a Semiótica expandiu suas fronteiras de análise para vários ramos da atividade humana, propondo modelos pautados nos aspectos invariantes e as especificidades do objeto a ser estudado (variantes). Apesar da expansão das fronteiras de análise semiótica, a proposta deste artigo é o de discutir a possibilidade de aplicação dos preceitos semióticos não apenas como subsídio de processos analíticos dos diversos tipos de texto ou atividades humanas, mas também como proposto por Jacques Fontanille (2021): como uma forma de intervenção da prática pedagógica didática, ou seja, de uma Semiótica Didática, propriamente dita, capaz de projetar o efeito de sentido no processo educacional.
Representação da mulher no livro didático e o ensino de Geografia
Authors: Lacerda Rosana Soares de , Peluso Marília Luiza 
Published: May 2024

O livro didático é um dos recursos mais utilizados no espaço escolar. Assim, as representações partilhadas por meio desse recurso exercem influências sobre o público a que se destina. Diante disso, questiona-se: qual é a Representação Social de mulher partilhada pela obra didática Prisma: ciências humanas, volume Brasil da Diversidade: Sociedade e Direitos? Para responder ao questionamento, elencou-se como objetivos, identificar a Representação Social da mulher na obra didática Prisma: Ciências humanas – Brasil da diversidade: sociedade e direitos e discutir as possibilidades de abordagens sobre as questões femininas a partir do ensino de Geografia. Desse modo, através da Teoria da Representação Social (RS), de Serge Moscovici, analisou-se o volume mencionado e identificou-se que há uma representação positiva sobre a mulher, uma vez que evidencia o empoderamento e distintas formas de ativismo feminino em diferentes escalas geográficas. Além disso, enaltece o protagonismo de mulheres de diferentes idades, etnias e contextos. Assim sendo, percebe-se que a figura feminina é valorizada e evidenciada como atuante. Nesse sentido, para o ensino de Geografia que fica passível de ser trabalhado pela área de conhecimento de Ciências Humanas e Sociais Aplicadas, pode-se encontrar terreno fértil nesse cenário, no entanto, a depender da formação do professor, corre-se o risco de esvaziamento de conteúdos, uma vez que as temáticas são abordadas de forma muito superficial, necessitando de aprofundamento por parte desse profissional que pode encontrar dificuldades em geografizá-los de forma satisfatória.
DOCÊNCIA ENTRE GRADES: REDE DE RELAÇÕES E IDENTIDADE PROFISSIONAL DOCENTE
Authors: Pereira Marileia Santos , Guisso Luana Frigulha 
Published: May 2024

O presente estudo busca descrever como a rede de relações com os alunos e agentes envolvidos no processo educativo pode exercer influênciana subjetividade da construção da identidade profissional docente. A pesquisa contou com a participação de 12 professores da instituição escolar no interior da prisão e, destes, 10 atuam no sistema prisonal , e dois encerraram suas atividades pedagógicas em 2022. Para tanto, foram utilizados instrumentos de coletas de dados por meio de entrevistas e diário de bordo. Os resultados promovem uma parcela significativa na constituição da construção da identidade docente. A experiência docente em espaço de privação de liberdade permeia não só a vida profissional, mas também as suas subjetividades da concepção do ser docente no cárcere.
EFFECTIVENESS OF SHORTENED FOUR-DRUG CHEMOTHERAPY REGIMENS IN THE COMPLEX TREATMENT FOR MDR/XDR-TB IN ADOLESCENTS
Authors:   Central TB Research Institute, Moscow, Russia, Panova L.V , Ovsyankina E.S. ,   Central TB Research Institute, Moscow, Russia
Published: May 2024

Objective: to assess effectiveness of shortened to 12 months chemotherapy regimens containing 4 TB drugs in older children and adolescents with multidrug resistant (MDR) or extensively drug resistant (XDR) pulmonary TB. Materials and methods. We carried out a cohort retrospective study from January 2017 through December 2021. The study enrolled 37 patients aged 13–17 years with various clinical forms of pulmonary TB and established MDR/XDR. The patients were divided into two observation groups: in group 1 (main) 10 patients received continuous treatment containing 4 drugs;in group 2 (comparison) 27 patients received 5-6 drugs during the intensive phase (3 or 6 months) and 3 drugs during the continuation phase (6 or 9 months). The statistical correlation between the risk factor (four-drug chemotherapy regimen) and the outcome (TB relapse) was calculated using the Pearson’s χ2 criterion. The difference p ≤ 0.05 was considered statistically significant. Results. One year after treatment completion we observed 34 out of 37 patients. According to X-ray data, only one (4.2%) of 24 patients of the comparison group developed TB relapse. The comparison of TB relapse incidence in the two groups did not reveal a statistically significant correlation between the risk factor (four-drug chemotherapy regimen) and the outcome (TB relapse) (χ2 = 0.429; р > 0.05). Conclusion. The use of shortened four-drug chemotherapy regimens is an important achievement and changes the approach to treatment of children and adolescents with drug-resistant pulmonary TB.