bluuebunny/crossref_metadata_2025_split huggingface dataset:
The synthesis of macrocyclic polyether‐diester compounds with a pyridine subcyclic unit
Authors: Bradshaw J. S. , Asay R. E. , Maas G. E. , Izatt R. M. , Christensen J. J. 
Published: April 2009

AbstractTwo new series of macrocyclic polyether‐diester ligands (4‐15) containing a pyridine subcyclic unit have been prepared by treating various oligoethylene glycols and sulfur‐containing oligo‐ethylene glycols with 2,6‐ and 3,5‐pyridine dicarbonyl chlorides. The compounds prepared from 2,6‐pyridine dicarbonyl chloride were: 3,6,9,12‐tetraoxa‐18‐azabicyclo[12.3.1 ]oetadeca‐1(18), 14,16‐triene‐2,13‐dione (4); 3,6,9,12,15‐pentaoxa‐21‐azabieyclo[15.3.1]heneicosa‐1(21),17,19‐triene‐2,16‐dione (5); 3,6,12,15‐tetraoxa‐9‐thia‐21‐azabicyclo[15.3.1 ]heneicosa‐1(21),17,19‐tri‐ene‐2,16‐dione(6); 3,9,15‐trioxa‐6,12‐dithia‐21‐azabicyclo[15.3.1]heneicosa‐1(21),17,19‐triene‐2,16‐dione (7); 3,6,9,12,15,18‐hexaoxa‐24‐azabicyclo[18.3.1 ]tetracosa‐1(24),20,22‐triene‐2,19‐dione (8); 3,6,9,12,15,18,21‐heptaoxa‐27‐azabicyclo[21.3.1]heptacosa‐1(27),23,25‐triene‐2,22‐dione (9); and the corresponding analogues from 3,5‐pyridine dicarbonyl chloride (10‐15). The solid potassium thiocyanate complex of compound 5 was also prepared.
Quinazolines and 1,4‐benzodiazepines. LXXXVII. Synthesis of 1‐ and 3‐phenylimidazo[1,5‐a] [1,4]benzodiazepines
Authors: Walser A. , Lauer R. F. , Fryer R. Ian 
Published: April 2009

AbstractThe synthesis of the 1‐phenylimidazobenzodiazepine 5 from 1 and the anion of the nitrone 2 is described. The 3‐phenyl‐derivative 14 was prepared via the ammo alcohol 11 which was obtained by condensation of the nitrosamine 9 with benzaldehyde followed by catalytic hydro‐genolysis of the nitroso group.
Un nouvel hétérocycle telluré: le benzisotellurazole‐1,2. I. Synthèse et propriétés
Authors: Weber Roland , Piette Jean‐Louis , Renson Marcel 
Published: April 2009

AbstractNous décrivons la synthèse, par deux méthodes différentes, d'un nouvel hétérocycle telluré de base, le benzisotellurazole‐1,2, et nous en comparons les propriétés avec celles des analogues sulfuré et sélénié correspondants.
New polyheterocyclic series based on 4,5,6,7‐tetrahydrothieno[2,3‐c]pyridine
Authors: Lalezari I. , Jabari‐Sahbari M. H. 
Published: April 2009

Abstract4,8‐Dimethyl‐6,7,8,9‐tetrahydropyrido[4′,3′:4,5]thieno[2,3‐e][1,2,4]triazolo[3,4‐a]‐4H‐pyrimidin‐5‐ones, 7‐methyl‐2,3,6,7,8,9‐hexahydropyrido[4′,3′:4,5]thieno[2,3‐d]pyrrolo[1,2‐a]‐1H, 10H‐pyrimidin‐10‐one, 8‐methyl‐1,2,3,4,7,8,9,10‐octahydropyrido[4′,3′:4,5]thieno[2,3‐d]‐11H‐pyrimidin‐11‐one, and 9‐methyl‐2,3,4,5,8,9,10,11‐octahydro[4′,3′:4,5]thieno[2,3‐d]azepino‐[1,2‐a]‐1H, 12H‐pyrimidin‐12‐one which consist four new heterocyclic ring systems were synthesized from 2‐amino‐3‐carbethoxy‐5‐methyl‐4,5,6,7‐tetrahydrothieno[2,3‐c]pyridine.
Synthesis of internal standards for analytical determinations of primidone, and its metabolite, phenylethylmalonamide (PEMA)
Authors: Dudley Kenneth H. , Bius Daniel L. , Maguire James H. 
Published: April 2009

AbstractSynthetic routes are described tor the preparation of internal standards for analytical determinations of the antiepileptic agent primidone (1) and one of its primary in vivo metabolites, phenylethylmalonamide (PEMA, 3). The internal standards synthesized in the present study are p‐methylprimidone (9) and p‐methylPEMA (8). The internal standards differ in structure from the parent drug and metabolite in that the phenyl substituents of the drug and metabolite have been replaced by p‐tolyl substituents. The synthetic route for the preparation of p‐methylPEMA (8) entailed conversion of an appropriately substituted malonate to a 4,4‐disubstituted pyrazoli‐dine‐3,5‐dione, and Raney nickel reduction of the latter substance to a malonamide. This same sequence of reactions was useful for the preparation of PEMA (3) itself. A fusion of p‐methylPEMA (8) with formic acid and formamidine acetate resulted in the formation of p‐methyl‐primidone (9).
Nucleosides de synthèse XVI: Sur une synthèse sélective de divers ribofuranosyl‐1‐purines
Authors: Montero J. L. , Dhainaut A. , Imbach J. L. 
Published: April 2009

AbstractCe travail décrit une approche générale de synthèse permettant de parvenir aux D‐ribo‐furanosyl‐1‐purines anomères par cyclisation de précurseurs imidazoliques correspondents. En particulier, les dérivés oxo‐6 et mercapto‐6 ont été décrits et leur structure confirmée par les méthodes physico‐chimiques usuelles d'analyse.
Formycin analogs. I. Model studies in the preparation of an isomer of formyein and related derivatives (s‐triazolo[4,3‐a] pyrazines)
Authors: Schneller S. W. , May J. L. 
Published: April 2009

AbstractThe synthesis of a number of 8‐substituted‐ and 3‐methyl‐8‐substituted‐.s‐triazolo[4,3‐a]‐pyrazines as model molecules for an isomer of formyein (i.e., 8‐amino‐3‐(β‐D‐ribofuranosyl)‐s‐triazolo[4,3‐a ]pyrazine (2)) and some of its derivatives (including aglycone) is reported. The C‐8 subslituents include amino (3a and 4a), chloro (3b and 4b), hydroxy (as the 8‐ones 8a and 9a), mercapto (as the 8‐thiones 8c and 9c), hydroxylamino (3e and 4e), selenoxy (as the 8‐selenones 8d and 9d), metlioxy (3g and 4g), and thiomethoxy (3h and 4h). Also described are 7‐methyl‐s‐triazolo[4,3‐a]pyrazin‐8(7H) one (8b) and its 3‐methyl derivative (9b) together with imidazo[1,2‐g]‐s‐triazolo[4,3‐a]pyrazine (10a) and its 3‐methyl derivative (10b). Complete spectral data for all of these molecules is presented.
Synthesis of 3‐aryl‐4‐isothiazolecarboxylates
Authors: Howe Robert K. , Cruner Terry A. , Carter Linda G. , Franz John E. 
Published: April 2009

AbstractA short, convenient route to 3‐aryl‐4‐isothiazolecarboxylates is described in which aryl Grig‐nard reagents are added to the magnesium etiolate of ethyl cyanoacetete, and the resultant β‐aminocinnamates are converted via a Vilsmeier‐Haack reaction, thiation, and oxidation to the isothiazolecarboxylates.
Derivatives of phenyl‐2,3‐dihydroimidazo[1,2‐a]pyridinone
Authors: Magatti Charles V. , Villani Frank J. 
Published: April 2009

AbstractThe title compounds were prepared by the condensation of a series of β‐keto esters with 2‐benzylimidazoline. A mechanism is proposed wherein the dienamine 4 undergoes an intramolecular acylation with the elimination of ethoxide and subsequent hydride shift.
Composés hétérocycliques à partir (testers cyaniques. 4. Synthèse de nouvelles aroxy‐2 quinazolinones‐4
Authors: Hedayatullah Mir , Pailler Jacques 
Published: April 2009

AbstractLa réaction de cyclisation entre les cyanates d'aryle et l'anthranilate d'éthyle et le N‐méthyl‐anthranilate d'éthyle, en présence d'acide benzoique comme catalyseur, constitue une méthode símple eégenérale de synthèse d'aroxy‐2 quinazolinones‐4 et d'aroxy‐2 méthyl‐I quinazolinones‐4 avec des rendements élevés pour des temps de contact de quelques minutes.
Kinetic study on the conversion of pyridine‐ and quinolinecarboxylic acids to the corresponding trichloromethyl compounds
Authors: Takahashi Kazuyuki , Takeda Koichi , Mitsuhashi Keiryo 
Published: April 2009

AbstractThe reaction rates of the conversion of various substituted picolinic and quinaldinic acids to the corresponding trichloromethylpyridines and quinolines by treatment with phosphorus pentachloride in refluxing thionyl chloride have been measured, and the apparent second‐order kinetic constants determined. The logarithmic rate constants (log k) were found to be linear with the basicities (pKa) of the unsaturated ring nitrogens in the substrates. The reaction constant, p, of the conversion was estimated.
Fourier transform 13C NMR analysis of benzodiazepines
Authors: Singh Shiva P. , Parmar Surendra S. , Farnum Sylvia A. , Stenberg Virgil I. 
Published: April 2009

AbstractThe natural abundance carbon‐13 nuclear magnetic resonance spectra of diazepam, clonazepam, flurazepam and chlordiazepoxide were recorded in suitable solvent using the Fourier transform technique on a JEOL FX‐60 spectrometer. The relaxation time (T1) of these compounds were also measured. The chemical shift of the various carbon resonances have been assigned on the basis of chemical shift theory, multiplicity generated in single‐frequency off‐resonance decoupled spectra, relaxation time and the chemical shifts of the model compounds.
Synthesis of 5‐(1 ‐naphthylmethyl)‐4‐aryl‐s‐triazole‐3‐thiol/yl‐thioglycolic acids as possible anti‐inflammatory agents
Authors: Kothari P. J. , Kishore V. , Stenberg V. I. , Parmar S. S. 
Published: April 2009

AbstractSeveral 5‐(1‐naphthylmethyl)‐4‐aryl‐S‐triazoIe‐3‐thiol/yl‐thioglycolic acids were prepared as possible anti‐inflammatory agents. The infrared, nuclear magnetic resonance and mass spectra of these compounds are reported.
Heterocycles. CLXIX. Barriers to rotation in some N,N‐Dimethyl‐N′‐heteroaryl, N,N‐Diethyl‐N′‐heteroaryl‐substituted formamidines and N,N‐Dimethyl‐N′‐heteroaryl‐substituted acetamidines
Authors: Drobnič‐Košorok M. , Polanc S. , Stanovnik B. , Tišler M. , Verček B. 
Published: April 2009

AbstractThe free energies of the rotational barriers, ΔG*, about CHNMe2 bond in N′‐heteroaryl N,N‐dimethylformamidines (A), about CHNEt2 bond in N‐heteroaryl N,N‐diethylformamidines (B), and about C(Me)NMe2 bond in N′‐heteroaryl N,N‐dimethylacetamidines (C) have been found to be in the range 17.5–20.1 kcal/mole for type A, 18.8–21.6 kcal/mole for type B and 13–14 kcal/mole or below for type C of compounds, respectively. The compounds of the types A and B exist in the forms IIa, IIIa, IV, V, and VI, while the compounds of the type C exist in the forms IIb and IIIb.
Synthesis of 10‐aminophenothiazines and derivatives
Authors: Corral Carlos , Lissavetzky Jaime , Quintanilla Gloria 
Published: April 2009

AbstractIn this paper it is shown that 2‐nitro‐2′‐(β‐acetyl) hydrazinodiphenyl sulfides cyclize, via a Smiles rearrangement, to 10‐acetylaminophenothiazines, which are inert to alkalis and suffer a strong decomposition by acids. 10‐Aminophenothiazine has been obtained by ring closure of 2‐bromo‐2′‐hydrazinodiphenyl sulfide via an assumed benzyne intermediate.
Synthesis of imidazo[1,2‐a] pyridinium salts from 2‐alkylaminopyridines. A reexamination
Authors: Kuhla Donald E. , Watson H. A. 
Published: April 2009

Abstract1‐Alkyl‐2‐hydroxy‐2,3‐dihydroimidazo [1,2‐a] pyridinium salts (III) have been identified as isolatable intermediates in the synthesis of 1‐alkylimidazo[1,2‐a] pyridinium salts (II) from 2‐alkylaminopyridines and α‐haloketones. Spectral data suggest that these intermediates exist exclusively as the cyclic ring tautomers III rather than chain tautomers VI.
Etude des conditions d'accès au triazino‐1,2,4‐[4,5‐b] indazole
Authors: Robba Max , Lancelot Jean‐Charles , Maume Daniel , Rabaron Alain 
Published: April 2009

AbstractLe dihydro‐1,2 oxo‐1 triazino‐1,2,4‐[4,5‐b] indazole et ses dérivés sont accessibles par transposition de l'[(oxadiazolyl‐1,3,4)‐2]‐3 indazole ou par cyclisation d'éthoxyméthylidène hydrazides indazoliques. La synthèse du dioxo‐1,4 tétrahydro‐1,2,3,4 triazino‐1,2,4‐[4,5‐b] indazole est realisable par cyclisation du N‐carbéthoxyhydrazide du carboxy‐3 indazole et celle du dihydro‐3,4 oxo‐4 triazino‐1,2,4‐[4,5‐b] indazole par cyclisation de la N‐carbéthoxy hydrazone du formyl‐3 indazole. Le triazino‐1,2,4‐ [4,5‐b] indazole est accessible par l'intermédiaire du dihydro‐1,2 thioxo‐1 triazino‐1,2,4‐[4,5‐b] indazole. Les spectres de rmn 1H sont étudiés.
Substituent effects on the mass spectrometric fragmentations of 4‐aryl‐3,3‐dichlorooxetan‐2‐ones
Authors: Krabbenhoft Herman O. 
Published: April 2009

AbstractThe electron impact mass spectrometric fragmentation pathways for a series of 4‐aryl‐3,3‐di‐chlorooxetan‐2‐ones were investigated. It was found that cleavage to radical cations of dichloroketene and/or the substituted benzaldehyde is preferred by a large measure to cleavage to radical cations of carbon dioxide and/or the substituted β,β‐dichlorostrene. Furthermore, it was demonstrated that the nature of the substituent has a significant influence on the localization of charge in the preferred direction of cleavage.
Novel heterocycles. 2. Synthesis of the 1,3,2‐benzodiazaphosphorin ring system
Authors: Coppola Gary M. , Mansukhani Ruth I. 
Published: April 2009

AbstractA series of 1,3‐disubstituted‐2,3‐dihydro‐1,3,2‐benzodiazaphosphorin‐4(1H)one 2‐oxides was prepared by a method involving the treatment of an appropriate anthranilamide with phosphorus trichloride. Tricyclic diazaphosphorins 24 and 28 were also prepared. Some spectral data of the products are also discussed.
Carbocyclisations et hétérocyclisation de dérivés orthodibenzylés, par action du soufre
Authors: Lepage Lucette , Lepage Yves 
Published: April 2009

AbstractLe diphényl‐1,4 dibenzyl‐2,3 butadiène est un bon précurseur de composes o‐dibenzylés grǎce à des réactions de cycloaddition. II permet aussi, par cyclisation, une synthèse d'un dérivé du naphtacène en trois étapes à partir de l'oxalate d'éthyle.L'action du soufre sur divers composés aromatiques o‐dibenzylés permet d'accéder à des benzo [c] thiophènes et měme à des naphto [2,3‐c] thiophènes; des réactions concurrentes de carbocyclisation avec formation de benzo[a]acéanthrylène et de dihydro indéno [2,1‐a] fluorène sont observées.
as‐Triazino[4,5‐α] indoles. III. Etude des substitutions électrophiles des triazinoindolones
Authors: Robba Max , Maume Daniel , Lancelot Jean‐Charles 
Published: April 2009

AbstractLes triazinoindolones‐1 et −4 1,2,3 se prětent a des réactions de substitution électrophile d'une part au niveau de l'azote lactamique au moyen d'agents électrophiles tels que le sulfate diméthylique ou le chlorure de benzyle et d'autre part au niveau de l'homocycle au moyen du brome ou de l'acide nitrique. Les réactions de bromation et de nitration aboutissent soit à des monosubstitutions en position 10, soit a des disubstitutions en position 7 et 10 ou 9 et 10 ou encore à des polysubstitutions conduisant à des melanges d'isomères tri ou tétrasubstitués. Les structures des dérivés obtenus ont été déterminées grǎce à plusieurs méthodes: rmn, étude de l'effet Overhauser et par synthèse univoque.
The coordination chemistry of simple phospholes. Complexes of rhenium, ruthenium, cobalt, rhodium and iridium chlorides and of some chlorocarbonyls of ruthenium and rhodium
Authors: Holah David G. , Hughes Alan N. , Hui Benjamin C. , Tse Pui‐Kwan 
Published: April 2009

AbstractThe reactions of 1‐phenylphosphole (PP), 3‐methyl‐1‐phenylphosphole (mPP), 3,4‐dimethyl‐1‐phenylphosphole (dPP) and, in certain instances, 1‐n‐butyl‐3,4‐dimethylphosphole (dBP) with some transition metal chlorides and some metal‐Cl‐CO systems are reported. These reactions show that simple phospholes in general unexpectedly behave much like ordinary tertiary phosphines and that, unlike the reactions with Ni(II), Pd(II) and Pt(II), the complexes formed are conventional in most respects. However, a few unusual reactions were observed. For example, mPP partially reduces Ru(III) to give a mixed‐valent Ru(III)‐Ru(II) complex while PP reduces Ir(III) to Ir(I). From infrared spectroscopic studies of the square‐planar Rh(I) complexes L2Rh(CO) Cl (L = phosphole), it appears that donor character decreases with decreasing substitution on the phosphole ring carbon atoms. Phosphorus‐phenyl cleavage has been observed in reactions of 1‐phenylphosphole with Rh‐CO systems. The results are briefly discussed in relation to the behaviour of other phospholes in similar reactions and in the context of the electronic structure of phospholes.
Thermal [1, 3] benzoyl migration in 1‐(α‐benzoyloxyarylideneamino)‐1,2,3‐triazoles. Part II
Authors: Kehrbach W. , Alexandrou N. E. 
Published: April 2009

Abstract1‐(α‐Benzoyloxyarylideneamino)‐4, 5‐dirnethyl‐1,2,3‐triazoles (V) were prepared by reacting the sodium salt of substituted 1‐benzoylamino‐4, 5‐dimethyl‐1,2,3‐triazoles (IV) with benzoyl chloride at −50°. The uncatalyzed thermal isomerization of isoimides V to the corresponding imides VI was studied kinetically and the reaction mechanism is discussed.
γ‐Lactones from malonic acid derivatives
Authors: Campaigne E. , Raval P. , Beckman J. C. 
Published: April 2009

AbstractThe acid catalyzed cyclization of isopropylidene malonate derivatives of ketones to form α‐earboxy‐γ‐lactones has been shown to occur with boron trifluoride etherate or p‐toluenesulfonic acid, as well as with concentrated sulfuric or polyphosphoric acids. A similar cyclization of a diethyl ylidenemalonate to a lactone ester, in relatively poor yield, has also been accomplished. Acid catalyzed cyclization of the ylidenemalononitrile derived from pinacolone to form an α‐carbamoyl‐γ‐lactone has been shown to occur with rearrangement. However, that derived from 2,2‐dimethyleyclohexanone cyclized to the secondary carbon of the ring without rearrangement. The isopropylidene malonate derivatives of several ring‐substituted and bridged ketones have been converted to α‐earboxy‐γ‐laetones without rearrangement.
Reissert compound studies. XXXI. Emetine analogs based on the reaction of the reissert anion with 1,3,4,6,7,11b‐hexahydro‐9, 10‐dimethoxybenzo[a] quinolizin‐2‐ones
Authors: Watts Raymond F. , Popp Frank D. 
Published: April 2009

AbstractReaction of the Reissert anion with the carbonyl group of 1,3,4,6,7,11b‐hexahydro‐9,10‐dimethoxybenzo[a]quinolizin‐2‐one and with 3‐ethyl‐1,2,3,4,6,7‐hexahydro‐9,10‐dimethoxy‐11bH‐benzo[a]quinolizin‐2‐carboxaldehyde give emetine analogs. This anion does not react with the carbonyl group of 3‐aIkyl‐1,3,4,6,7,11b‐hexahydro‐9,10‐dimethoxybenzo[a]quinolizin‐2‐one but instead gives a rearrangement product and the benzoquinolizinone cyanohydrin.
Reactions with heterocyclic amidines 1. Cyanoethylation of cyclic amidines
Authors: Fahmy Sherif Mahmoud , Kandeel Ezzat Mohamed , Elsayed El‐Farouk Rabia , Elnagdi Mohamed Hilmy 
Published: April 2009

Abstract2‐Amino‐5‐phenyl‐1,3,4‐oxadiazole (1a) and 2‐amino‐1,3,4‐thiadiazole (1b) reacted with acrylonitrile to yield β‐cyanoethylamino derivatives. On the other hand, 2‐amino‐4‐phenylthiazole (2) reacted with acrylonitrile under the same experimental conditions to yield a di‐β‐cyanoethylaminothiazole derivative. 3‐Phenyl‐Δ2‐1,2,4‐triazoline‐5‐thione reacted with acrylonitrile to yield the corresponding adduct. The structure of the adduct was established by its conversion into the acid 13 which could be synthesised via another independent route.
1,3‐Dipolar cycloadditions of anhydro‐5‐hydroxyoxazolium hydroxide generated from 2‐piperidinecarboxylic acid. Isolation of the primary adduct and synthesis of tetrahydroindolizines
Authors: Uchida Takane , Tsubokawa Shigeharu , Harihara Kiyoko , Matsumoto Kiyoshi 
Published: April 2009

Abstract1,3‐Dipolar cycloaddition reactions of anhydro‐5‐hydroxyoxazolium hydroxide 3 generated from 2‐piperidinecarboxylic acid and acetic anhydride, with dimethyl and diethyl acetylene‐dicarboxylates, dibenzoylacetylene, p‐benzoquinone, and 1,4‐naphthoquinone gave the corresponding tetrahydroindolizines. In the case of the reaction with p‐benzoquinone, the dihydroindolizine 12 was also formed. The primary N‐bridged lactone intermediate 4 was isolated from the reaction of 2 with dibenzoylacetylene. Several attempted conversions of these tetrahydroindolizines into the corresponding aromatic indolizines were fruitless.
Synthesis of 2,5‐disubstituted tetrazoles as possible antiinflammatory agents
Authors: Kishore Vimal , Parmar Surendra S. , Gildersleeve David L. 
Published: April 2009

AbstractSeveral 2‐(1‐acetoxy‐3‐substituted carbamido)‐5‐phenyltetrazoles were synthesized as possible antiinflammatory agents. Nmr spectroscopy was used as a tool in assigning the structure of the. Positional isomers of these substituted phenyltelrazoles. Compounds possessing antiinflammatory activity (100 mg./kg., i.p.) provided 11–41% protection against carrageenin‐induced edema in rats. Seven of these substituted phenyltelrazoles possessed antiproteolytic activity and the in vitro inhibition of trypsin activity during hydrolysis of bovine serum albumin ranged from 9–66%.
Reaktionen von 5‐diazourazilen mit primären aminen zu 1,2,3‐triazolcarbonsäurederivaten
Authors: Romani Sigrun , Klötzer W. 
Published: April 2009

AbstractThe reaction of 5‐diazouracils with saturated primary amines affords [(1‐alkyl‐1,2,3‐triazol‐4‐yl) carbonyl]ureas. The primary formation of a non‐isolable 6‐amine‐adduct 2 is followed by 1,6‐ring opening of the pyrimidone and ring closure to the triazole derivative.
3,5‐Disubstituted‐1,2,4‐oxadiazoles and 4,5‐dihydro‐3,5‐disubstituted‐1,2,4‐oxadiazoles
Authors: Yale Harry L. , Spitzmiller E. R. 
Published: April 2009

AbstractA series of 3,5‐disubstituted‐1,2,4‐oxadiazoles (2) were prepared from a mono‐ or dichlorophenyl‐substituted amidoxime and (i) an acid chloride, (ii) an isatoic anhydride, or (iii) a β‐keto ester. Although cyclizations of the same amidoximes with acetaldehyde gave 4,5‐dihydro‐5‐methyl‐substituted derivatives (5), that annulation procedure either failed or gave low yields with other aldehydes. A novel alternative method, the diborane reduction of 2, has been found to be a generally applicable procedure for preparing 5. The reduction is regioselective, i.e., only the 4,5‐(C=N) linkage is reduced even when a large excess of diborane is present.
Synthesis of benzofuro[3,2‐b] quinolin‐6(11H) one and derivatives
Authors: Sunder Shyam , Peet Norton P. 
Published: April 2009

AbstractA new and efficient synthesis of benzof'uro[3,2‐b]quinolin‐6(11H) one (3) is reported, by treatment of 2‐ {[(phenoxy)acetyl]amino} benzoic acid (6a) with polyphosphoric acid. An intermediate in the conversion of 3 to 6a, namely, 2‐(3‐benzofuranylamino)benzoic acid (7), was defined. An improved method for the synthesis of 6a is also described, which was used to prepare analogs (6b‐n) of 6a. In addition, an 11‐alkoxy derivative (8) and 11‐dialkylamino derivatives (10 and 11) of benzofuro [3,2‐b]quinoline were prepared from 3.
Carbon‐13 Nmr spectra of 1,2,3‐thiadiazoles
Authors: Looker James H. , Khatri Nazir A. , Patterson Ronald B. , Kingsbury Charles A. 
Published: April 2009

AbstractNatural abundance 13C nmr spectra are reported for 1,2,3‐thiadiazole and nine derivatives. The spectra are discussed in terms of α‐ and β‐effects of substituent groups and compared with corresponding spectra of alkene and benzene derivatives. 13C nmr spectra of four 1,3,4‐thiadiazoles are presented. Spectral data indicate that in dimethylsulfoxide solution 2‐mercapto‐5‐methyl‐1,3,4‐thiadiazole exists predominantly as the thione tautomer.
Benzofuro[2,3‐d]pyridazines IV. Etude de la chloro‐4 benzofuropyridazine
Authors: Robba Max , de Sévricourt Michel Cugnon , Godard Anne‐Marie 
Published: April 2009

AbstractLa [1]benzofuro[2,3‐d]pyridazine est accessible par plusieurs méthodes: réduction catalytique de la chloro‐4 benzofuropyridazine, déshydrazination oxydative de l'hydrazino‐4 benzofuropyridazine et désulfuration de la 4 H‐benzofuropyridazinethione‐4. Ses dérivés de substitution en 4 sont obtenus par attaque nucléophile de la chloro‐4 benzofuropyridazine alors que la tétrazolo[1,5‐b]‐ et les s‐triazolo[1,2‐b]benzofuro[2,3‐d]pyridazines sont accessibles par cyclisation de l'hydrazino‐4 benzofuropyridazine. L'analyse du spectre de rmn de la benzofuropyridazine a été effectuée grǎce à l'étude de l'effet Overhauser.
Acylation of heteroaromatic amines . Perbenzoylation of diaminopyridazines
Authors: Suzuki Toshinobu , Katou Nobuhiro , Mitsuhashi Keiryo 
Published: April 2009

AbstractSome diaminopyridazines such as 4,7‐diaminoimidazo[4,5‐d]pyridazine, 1‐methyl‐4,7‐diaminoimidazo[4,5‐d]pyridazine, 5,8‐diaminopyrazino[2,3‐d]pyridazine, 2,3‐dimethyl‐5,8‐diaminopyrazino[2,3‐d]pyridazine and 1,4‐diaminophthalazine, all of which were prepared by the reaction of hydrazine with the respective vic‐dicyanide as starting material, were reacted with benzoyl chloride in the presence of triethylamine, giving novel perbenzoylated derivatives in good yield. A dibenzoylation mechanism of the amino group has been proposed.