bluuebunny/crossref_metadata_2025_split huggingface dataset:
Climatological Mean Circulation at the New England Shelf Break
Authors: Zhang Weifeng G. , Gawarkiewicz Glen G. , McGillicuddy Dennis J. , Wilkin John L. 
Published: May 2011

Abstract
A two-dimensional cross-shelf model of the New England continental shelf and slope is used to investigate the mean cross-shelf and vertical circulation at the shelf break and their seasonal variation. The model temperature and salinity fields are nudged toward climatology. Annual and seasonal mean wind stresses are applied on the surface in separate equilibrium simulations. The along-shelf pressure gradient force associated with the along-shelf sea level tilt is tuned to match the modeled and observed depth-averaged along-shelf velocity. Steady-state model solutions show strong seasonal variation in along-shelf and cross-shelf velocity, with the strongest along-shelf jet and interior onshore flow in winter, consistent with observations. Along-shelf sea level tilt associated with the tuned along-shelf pressure gradient increases shoreward because of decreasing water depth. The along-shelf sea level tilt varies seasonally with the wind and is the strongest in winter and weakest in summer. A persistent upwelling is generated at the shelf break with a maximum strength of 2 m day−1 at 50-m depth in winter. The modeled shelfbreak upwelling differs from the traditional view in that most of the upwelled water is from the upper continental slope instead of from the shelf in the form of a detached bottom boundary layer.
A Dynamical Performance-Ranking Method for Predicting Individual Ensemble Member Performance and Its Application to Ensemble Averaging
Authors: Du Jun , Zhou Binbin 
Published: May 2011

Abstract
This study proposes a dynamical performance-ranking method (called the Du–Zhou ranking method) to predict the relative performance of individual ensemble members by assuming the ensemble mean is a good estimation of the truth. The results show that the method 1) generally works well, especially for shorter ranges such as a 1-day forecast; 2) has less error in predicting the extreme (best and worst) performers than the intermediate performers; 3) works better when the variation in performance among ensemble members is large; 4) works better when the model bias is small; 5) works better in a multimodel than in a single-model ensemble environment; and 6) works best when using the magnitude difference between a member and its ensemble mean as the “distance” measure in ranking members. The ensemble mean and median generally perform similarly to each other.
This method was applied to a weighted ensemble average to see if it can improve the ensemble mean forecast over a commonly used, simple equally weighted ensemble averaging method. The results indicate that the weighted ensemble mean forecast has a smaller systematic error. This superiority of the weighted over the simple mean is especially true for smaller-sized ensembles, such as 5 and 11 members, but it decreases with the increase in ensemble size and almost vanishes when the ensemble size increases to 21 members. There is, however, little impact on the random error and the spatial patterns of ensemble mean forecasts. These results imply that it might be difficult to improve the ensemble mean by just weighting members when an ensemble reaches a certain size. However, it is found that the weighted averaging can reduce the total forecast error more when a raw ensemble-mean forecast itself is less accurate. It is also expected that the effectiveness of weighted averaging should be improved when the ensemble spread is improved or when the ranking method itself is improved, although such an improvement should not be expected to be too big (probably less than 10%, on average).
Improved Representation of Boundary Layer Clouds over the Southeast Pacific in ARW-WRF Using a Modified Tiedtke Cumulus Parameterization Scheme*
Authors: Zhang Chunxi , Wang Yuqing , Hamilton Kevin 
Published: May 2011

Abstract
A modified Tiedtke cumulus parameterization (CP) scheme has been implemented into the Advanced Research Weather Research and Forecasting model (ARW-WRF) to improve the representation of marine boundary layer (MBL) clouds over the southeast Pacific (SEP). A full month simulation for October 2006 was performed by using the National Centers for Environmental Prediction (NCEP) final analysis (FNL) as both the initial and lateral boundary conditions and the observed sea surface temperature (SST). The model simulation was compared with satellite observations and with results from an intense ship-based campaign of balloon soundings during 16–20 October 2006 at 20°S, 85°W.
The model with the modified Tiedtke scheme successfully captured the main features of the MBL structure and low clouds over the SEP, including the geographical distribution of MBL clouds, the cloud regime transition, and the vertical structure of the MBL. The model simulation was repeated with the various CP schemes currently provided as standard options in ARW-WRF. The simulations with other CP schemes failed to reproduce the geographical distribution of cloud fraction and the observed cloud regime transition, and displayed an MBL too shallow compared to observations. The improved simulation with the modified Tiedtke scheme can be attributed to a more active parameterized shallow convection with the modified Tiedtke scheme than with the other CP schemes tested, which played a critical role in lifting the inversion base and the low cloud layer. Results from additional sensitivity experiments employing different planetary boundary layer (PBL) parameterization schemes demonstrated that the basic feature of the MBL structure and low clouds over the SEP were not particularly sensitive to the choice of the PBL scheme.
The Low-Level Atmospheric Circulation near Tongoy Bay–Point Lengua de Vaca (Chilean Coast, 30°S)
Authors: Rahn David A. , Garreaud René D. , Rutllant José A. 
Published: May 2011

Abstract
Strong southerly, terrain parallel winds often occur along the coast of north-central Chile (25°–35°S) embedded in the marine atmospheric boundary layer and the lower part of the capping temperature inversion. Their offshore structure and variability have received considerable attention because of the effect on open-ocean processes and connection with the southeast Pacific cloud layer. Mesoscale low-level circulations linked to the coastal topography (e.g., coastal jets and sea breeze) are less studied in Chile, but are particularly relevant as they alter the upper-ocean circulation and the cloud pattern in the nearshore strip.
Surface, radiosonde, and airborne meteorological observations near point Lengua de Vaca (LdV)–Tongoy Bay (TB) at 30°S are used alongside numerical modeling to understand the local circulation near a prominent upwelling center. Most observations were gathered during the Variability of the American Monsoon Systems (VAMOS) Ocean–Cloud–Atmosphere–Land Study Chilean Upwelling Experiment (VOCALS-CUpEx) during two weeks in late spring 2009. The regional topography resembles other major capes, but south of TB and east of LdV there is a low (100–300 m), dry marine terrace bounded by high elevation at the coast (~600 m) and farther inland. Coastal soundings 25 km upstream of LdV revealed a southerly wind maximum near the surface and another at 900 m separated by a destabilized layer, deviating from the two-layer model often applied to coastal flow. In the morning a shallow sea breeze penetrates from TB to the marine terrace, but is overridden by southerly flow in the afternoon. Furthermore, between 400 and 900 m, warm continental air is advected from over the marine terrace creating a residual boundary layer over TB. Concurrent with slower changes offshore, the low-level warming over TB leads to a marked cross-shore pressure gradient enhancing the coastal jet just north of LdV.
Short-term Teriparatide Delivery and Osseointegration: a Clinical Feasibility Study
Authors: Kuchler U. , Luvizuto E.R. , Tangl S. , Watzek G. , Gruber R. 
Published: May 2011

Teriparatide is an anabolic osteoporosis therapeutic agent that can improve healing after fractures and periodontal surgeries. Clinical studies investigating the effects of teriparatide on the osseointegration of titanium implants have not been performed. We conducted an open-label randomized controlled feasibility study and included 24 individuals with edentulous lower jaws. The participants received 2 study implants in the mandible during interforaminal dental implant surgery. They were randomly assigned to receive either 20 µg of teriparatide once daily for 28 days or no treatment. Study implants were retrieved from 23 participants after 9 weeks and were subjected to histomorphometric analyses. Endpoints were new bone-volume-per-tissue-volume (NBV/TV) and new bone-to-implant-contact (NBIC). We report here that median values of NBV/TV in the control and the teriparatide groups were 15.4% vs. 17.6% in the periosteal compartment, 11.3% vs. 16.5% in the cortical compartment, and 7.3% vs. 12.0% in the medullary compartment, respectively. NBIC median values in the control and the teriparatide groups were 3.3% vs. 4.1% in the periosteal compartment, 5.0% vs. 4.4% in the cortical compartment, and 0.3% vs. 1.4% in the medullary compartment, respectively. The results provide the first histological data on the osseointegration of titanium study implants in individuals treated with teriparatide. ClinicalTrials.gov number, NCT00089674. Abbreviations: NBV/ TV, new bone-volume per tissue volume; NBIC, new bone-to-implant contact; BV/TV, bone-volume per tissue volume; BIC, bone-to-implant contact; ROI, region of interest.
Ear, Nose, and Throat Manifestations during Pregnancy
Authors: Kumar Rohit , Hayhurst Kathryn L. , Robson Andrew K. 
Published: May 2011

ObjectiveThe objective of this clinical review is to highlight the otolaryngological symptoms that occur in pregnancy. Where available, the authors discuss the current evidence of the etiology and management of the various presentations. While it is appreciated that many of these complaints are transient, their impact on the maternal quality of life can be significant, and therefore, medical practitioners should be aware of what to expect in order to provide reassurance to patients and also to safely manage such symptoms.Data SourcesMEDLINE and EMBASE databases were searched for publications related to otolaryngology and pregnancy.Review MethodsAll literature was searched for and reviewed by 2 authors independently. Search results were then cross‐examined, and any differences were settled by consensus.ResultsPregnancy leads to circulatory changes and increased susceptibility to viral reactivation, and along with the exertion of parturition, it can lead to tinnitus, facial palsies, and deafness. Rising levels of sex hormones and heightened sensitivity to allergens may influence the nasal mucosa, precipitating epistaxis and rhinitis. Increased progesterone and the increased intra‐abdominal pressure of the growing fetus can lead to symptoms and sequelae of laryngopharyngeal reflux. Evidence for the treatment of pregnancy‐induced symptoms is principally restricted to case reports and retrospective studies.ConclusionRecognition and understanding of pregnancy‐related ear, nose, and throat complaints will allow otolaryngologists to reassure and manage these patients, improving their experience of the gestational period. High‐quality evidence for their management is limited, with further research required.
Augmentation of a Rotator Cuff Suture Repair Using rhPDGF-BB and a Type I Bovine Collagen Matrix in an Ovine Model
Authors: Hee Christopher K. , Dines Joshua S. , Dines David M. , Roden Colleen M. , Wisner-Lynch Leslie A. , Turner A. Simon , Mcgilvray Kirk C. , Lyons Amy S. , Puttlitz Christian M. , Santoni Brandon G. 
Published: May 2011

Background Rotator cuff tears are a common source of shoulder pain. High rates (20%-94%) of structural failure of the repair have been attributed to multiple factors, including poor repair tissue quality and tendon-to-bone integration. Biologic augmentation using growth factors has potential to promote tendon-to-bone integration, improving the function and long-term success of the repair. One such growth factor is platelet-derived growth factor–BB (PDGF-BB), which has been shown to improve healing in tendon and bone repair models. Hypothesis Recombinant human PDGF-BB (rhPDGF-BB) combined with a highly porous type I bovine collagen matrix will improve the biomechanical function and morphologic appearance of the repair in a dose-dependent manner, relative to a suture-only control, after 12 weeks in an acute ovine model of rotator cuff repair. Study Design Controlled laboratory study. Methods An interpositional graft consisting of rhPDGF-BB and a type I collagen matrix was implanted in an ovine model of rotator cuff repair. Biomechanical and histologic analyses were performed to determine the functional and anatomic characteristics of the repair after 12 weeks. Results A significant increase in the ultimate load to failure was observed in repairs treated with 75 μg (1490.5 ± 224.5 N, P = .029) or 150 μg (1486.6 ± 229.0 N, P = .029) of rhPDGF-BB, relative to suture-only controls (910.4 ± 156.1 N) and the 500-μg rhPDGF-BB group (677.8 ± 105.9 N). The 75-μg and 150-μg rhPDGF-BB groups also exhibited increased tendon-to-bone inter-digitation histologically. No differences in inflammation or cellularity were observed among treatments. Conclusion This study demonstrated that an interpositional graft consisting of rhPDGF-BB (75 or 150 μg) and a type I collagen matrix was able to improve the biomechanical strength and anatomic appearance in an ovine model of rotator cuff repair compared to a suture-only control and the 500-μg rhPDGF-BB group. Clinical Relevance Recombinant human PDGF-BB combined with a type I collagen matrix has potential to be used to augment surgical repair of rotator cuff tears, thereby improving clinical success.
Extensive HLA-driven viral diversity following a narrow-source HIV-1 outbreak in rural China
Authors: Dong Tao , Zhang Yonghong , Xu Ke Yi , Yan Huiping , James Ian , Peng Yanchun , Blais Marie-Eve , Gaudieri Silvana , Chen Xinyue , Lun Wenhui , Wu Hao , Qu Wen Yan , Rostron Tim , Li Ning , Mao Yu , Mallal Simon , Xu Xiaoning , McMichael Andrew , John Mina , Rowland-Jones Sarah L. 
Published: May 2011

AbstractObstacles to developing an HIV-1 vaccine include extensive viral diversity and lack of correlates of protective immunity. High mutation rates allow HIV-1 to adapt rapidly to selective forces such as antiretroviral therapy and immune pressure, including HIV-1–specific CTLs that select viral variants which escape T-cell recognition. Multiple factors contribute to HIV-1 diversity, making it difficult to disentangle the contribution of CTL selection without using complex analytical approaches. We describe an HIV-1 outbreak in 231 former plasma donors in China, where a narrow-source virus that had contaminated the donation system was apparently transmitted to many persons contemporaneously. The genetic divergence now evident in these subjects should uniquely reveal how much viral diversity at the population level is solely attributable to host factors. We found significant correlations between pair-wise divergence of viral sequences and HLA class I genotypes across epitope-length windows in HIV-1 Gag, reverse transcriptase, integrase, and Nef, corresponding to sites of 140 HLA class I allele-associated viral polymorphisms. Of all polymorphic sites across these 4 proteins, 24%-56% were sites of HLA-associated selection. These data confirm that CTL pressure has a major effect on inter-host HIV-1 viral diversity and probably represents a key element of viral control.
Exome sequencing reveals germline NPAT mutation as a candidate risk factor for Hodgkin lymphoma
Authors: Saarinen Silva , Aavikko Mervi , Aittomäki Kristiina , Launonen Virpi , Lehtonen Rainer , Franssila Kaarle , Lehtonen Heli J. , Kaasinen Eevi , Broderick Peter , Tarkkanen Jussi , Bain Barbara J. , Bauduer Frédéric , Ünal Ali , Swerdlow Anthony J. , Cooke Rosie , Mäkinen Markus J. , Houlston Richard , Vahteristo Pia , Aaltonen Lauri A. 
Published: May 2011

Abstract
A strong clustering of Hodgkin lymphoma in certain families has been long acknowledged. However, the genetic factors in the background of familial Hodgkin lymphoma are largely unknown. We have studied a family of 4 cousins with a rare subtype of the disease, nodular lymphocyte predominant Hodgkin lymphoma. We applied exome sequencing together with genome-wide linkage analysis to this family and identified a truncating germline mutation in nuclear protein, ataxia-telangiectasia locus (NPAT) gene, which segregated in the family. We also studied a large number of samples from other patients with Hodgkin lymphoma, and a germline variation leading to the deletion of serine 724 was found in several cases suggesting an elevated risk for the disease (odds ratio = 4.11; P = .018). NPAT is thus far the first gene implicated in nodular lymphocyte predominant Hodgkin lymphoma predisposition.
BCL2/BCL-XL inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation
Authors: Vogler Meike , Hamali Hassan A. , Sun Xiao-Ming , Bampton Edward T. W. , Dinsdale David , Snowden Roger T. , Dyer Martin J. S. , Goodall Alison H. , Cohen Gerald M. 
Published: May 2011

AbstractApoptosis in megakaryocytes results in the formation of platelets. The role of apoptotic pathways in platelet turnover and in the apoptotic-like changes seen after platelet activation is poorly understood. ABT-263 (Navitoclax), a specific inhibitor of antiapoptotic BCL2 proteins, which is currently being evaluated in clinical trials for the treatment of leukemia and other malignancies, induces a dose-limiting thrombocytopenia. In this study, the relationship between BCL2/BCL-XL inhibition, apoptosis, and platelet activation was investigated. Exposure to ABT-263 induced apoptosis but repressed platelet activation by physiologic agonists. Notably, ABT-263 induced an immediate calcium response in platelets and the depletion of intracellular calcium stores, indicating that on BCL2/BCL-XL inhibition platelet activation is abrogated because of a diminished calcium signaling. By comparing the effects of ABT-263 and its analog ABT-737 on platelets and leukemia cells from the same donor, we show, for the first time, that these BCL2/BCL-XL inhibitors do not offer any selective toxicity but induce apoptosis at similar concentrations in leukemia cells and platelets. However, reticulated platelets are less sensitive to apoptosis, supporting the hypothesis that treatment with ABT-263 induces a selective loss of older platelets and providing an explanation for the transient thrombocytopenia observed on ABT-263 treatment.
Genome-wide expression profiling of the response to short-term exposure to fluconazole in Cryptococcus neoformans serotype A
Authors: Florio Ada Rita , Ferrari Selene , De Carolis Elena , Torelli Riccardo , Fadda Giovanni , Sanguinetti Maurizio , Sanglard Dominique , Posteraro Brunella 
Published: May 2011

Abstract

Background
Fluconazole (FLC), a triazole antifungal drug, is widely used for the maintenance therapy of cryptococcal meningoencephalitis, the most common opportunistic infection in AIDS patients. In this study, we examined changes in the gene expression profile of the C. neoformans reference strain H99 (serotype A) following FLC treatment in order to investigate the adaptive cellular responses to drug stress.

Results
Simultaneous analysis of over 6823 transcripts revealed that 476 genes were responsive to FLC. As expected up-regulation of genes involved in ergosterol biosynthesis was observed, including the azole target gene ERG11 and ERG13, ERG1, ERG7, ERG25, ERG2, ERG3 and ERG5. In addition, SRE1 which is a gene encoding a well-known regulator of sterol homeostasis in C. neoformans was up-regulated. Several other genes such as those involved in a variety of important cellular processes (i.e. lipid and fatty acid metabolism, cell wall maintenance, stress and virulence) were found to be up-regulated in response to FLC treatment. Conversely, expression of AFR1, the major transporter of azoles in C. neoformans, was not regulated by FLC.

Conclusions
Short-term exposure of C. neoformans to FLC resulted in a complex altered gene expression profile. Some of the observed changes could represent specific adaptive responses to the antifungal agent in this pathogenic yeast.
Parental willingness to pay for child safety seats in Mashad, Iran
Authors: Jarahi Lida , Karbakhsh Mojgan , Rashidian Arash 
Published: May 2011

AbstractBackgroundIran has one of the highest rates of road traffic crash death rates throughout the world and road traffic injuries are the leading cause of years of life lost in the country. Using child car safety seats is not mandatory by law in Iran. The purpose of this research was to determine the parental willingness to pay (WTP) for child restraints in Mashad, the second most populated city in Iran with one of the highest rates of road traffic-related deaths.MethodsWe surveyed 590 car-owner parents of kindergarten children who were willing to participate in the study in the year 2009. We asked them about the maximum amount of money they were willing to pay for car safety seats using contingent valuation method.ResultsThe mean age of children was 33.5 months. The median parental WTP for CSS was about $15. Considering the real price of CSSs in Iran, only 12 percent of responders could be categorized as being willing to pay for it. Family income level was the main predictor of being willing to pay.ConclusionsThe median parental WTP was much lower than the actual price of the safety seats, and those who were of lower socio-economic class were less willing to pay. Interventions to increase low-income families' access to child safety seats such as providing free of charge or subsidized seats, renting or health insurance coverage should be considered.
Nutritional status of pre-school children from low income families
Authors: Shoeps Denise O , de Abreu Luiz Carlos , Valenti Vitor E , Nascimento Viviane G , de Oliveira Adriana G , Gallo Paulo R , Wajnsztejn Rubens , Leone Claudio 
Published: May 2011

Abstract

Background
We evaluated growth and nutritional status of preschool children between 2 and 6 years old from low income families from 14 daycare centers.

Methods
Cross-sectional study with 1544 children from daycare centers of Santo Andre, Brazil. Body weight (W), height (H) and body mass index (BMI) were classified according to the 2000 National Center for Health Statistics (CDC/NCHS). Cutoff points for nutritional disorders: -2 z scores and 2.5 and 10 percentiles for malnutrition risk, 85 to 95 percentile for overweight and above BMI 95 percentile for obesity. Stepwise Forward Regression method was used including age, gender, birth weight, breastfeeding duration, age of mother at birth and period of time they attended the daycare center.

Results
Children presented mean z scores of H, W and BMI above the median of the CDC/NCHS reference. Girls were taller and heavier than boys, while we observed similar BMI between both genders. The z scores tended to rise with age. A Pearson Coefficient of Correlation of 0.89 for W, 0.93 for H and 0.95 for BMI was documented indicating positive association of age with weight, height and BMI. The frequency of children below -2 z scores was lower than expected: 1.5% for W, 1.75% for H and 0% for BMI, which suggests that there were no malnourished children. The other extremity of the distribution evidenced prevalence of overweight and obesity of 16.8% and 10.8%, respectively.

Conclusion
Low income preschool children are in an advanced stage of nutritional transition with a high prevalence of overweight.