bluuebunny/crossref_metadata_2025_split huggingface dataset:
DC Power Boosting Circuit for Freestanding‐Sliding Triboelectric Nanogenerators with High Intrinsic Impedance and Multi‐Harmonic Output
Authors: Lee Kibae , Kim Ji‐Seok , Oh Saewoong , Yoo Hyunjoon , Lee Jongkil , Oh Il‐Kwon , Lee Chong Hyun 
Published: June 2024

AbstractThis study presents a freestanding sliding triboelectric nanogenerator (FS‐TENG) designed for low‐frequency motions (below 2 Hz). However, for practical applications, an efficient power management strategy is required to handle the harmonic outputs of the FS‐TENG. The high‐frequency signal is not sustainable for powering low‐power electronic applications. To address the issue, a novel direct current power supply circuit (DPS) is proposed that utilizes a double charge circuit (DCC) and a comb filtering circuit (CFC) to efficiently harness harmonic sources from the FS‐TENG. The direct power supply (DPS) outperforms traditional converters by reducing the impedance of the FS‐TENG and collecting the target harmonic sources, which facilitates a continuous power supply to the load. The results demonstrate that the DPS is capable of providing a continuous DC voltage of 2.2 V to a 10 MΩ load with minimal ripple (0.039%) at a low operating frequency of 0.625 Hz. Additionally, the practical application of a self‐powered temperature sensor is demonstrated to highlight the potential of FS‐TENG and DPS for low‐frequency energy harvesting solutions in real‐world scenarios.
Metasurface Platform Incorporating Aggregation Induced Emission Based Biosensor for Enhanced Human Serum Albumin Detection
Authors: Hu Qi , Iwanaga Masanobu , Tang Youhong 
Published: June 2024

AbstractMetasurfaces exhibit excellent optical performance to enhance the light–matter interaction of target molecules in biosensing based on its well‐optimized nanostructured unit cells. In the meantime, fluorescence (FL) biosensors with aggregation induced emissions (AIE) features also demonstrate outstanding performance in biomarker detection due to their fast response, high selectivity, and low background noise. Nevertheless, extremely low‐level analytes are difficult to detect in practical applications since complex urine samples include a number of uncontrolled variables such as impurities, autofluorescence, other urine components, etc. At present, improving optical signal sensitivity of human serum albumin (HSA) detection is always a big challenge to overcome such interference in human urine scenarios. In this work, first an AIE‐based FL biosensor TPE‐4TA is combined with an all‐dielectric metasurface platform to achieve quantitative detection of trace HSA in urine by utilizing biofunctionalization protocols on the silicon (Si) nanostructures. The results indicate significant FL enhancement in the metasurface platform that offers a promising pathway for improving biomarker detection in the future.
Multiple Sampling Capsule Robot for Studying Gut Microbiome
Authors: Park Sanghyeon , Hoang Manh Cuong , Kim Jayoung , Park Sukho 
Published: June 2024

Longitudinal analysis of the gut microbiota is crucial for understanding its relationship with gastrointestinal (GI) diseases and advancing diagnostics and treatments. Most ingestible sampling devices move passively within the GI tract, rely on physiological factors, and fail at multipoint sampling. This study proposes a multiple‐sampling capsule robot capable of collecting gut microbiota from various locations within the GI tract with minimal cross‐contamination. The proposed capsule comprises a body, a driving unit, six sampling tools, a central rod, and two heads. Electromagnetic field control facilitates control of the orientation and position of the capsule, particularly to align the channel of the capsule where the sample is collected facing downward. The capsule can collect six gut microbiota samples preventing contamination before and after sampling. The active locomotion and multiple sampling performance of the capsule are evaluated through basic performance tests (propulsion direction precision: 0.76 ± 0.52°, channel alignment precision: 0.84 ± 0.55°), phantom tests (average amount per sample: 10.3 ± 2.4 mg, cross‐contamination: 0.6 ± 0.4%), and ex‐vivo tests (average amount per sample: 9.9 ± 1.7 mg). The possibility of integration and clinical application of the capsule is confirmed through preclinical tests using a porcine model.
HFIP‐Mediated Cyclodesulfurization Approach for the Synthesis of 2‐Aminobenzoxazole and 2‐Aminobenzothiazole Derivatives
Authors: Kant Kamal , Patel Chandresh K. , Banerjee Sourav , Naik Priyadarshini , Padhi Aditya , Sharma Vishal , Singh Virender , Almeer Rafa , Keremane Kavya S. , Atta Ananta K. , Malakar Chandi C. 
Published: June 2024

AbstractA straightforward strategy for the synthesis of pharmaceutically active 2‐aminobenzoxazoles and 2‐aminobenzothiazoles is described by using 2‐aminophenols, 2‐aminothiophenols, and functionalized phenylisothiocyanates as the model substrates. The developed method proceeds through the HFIP‐promoted cyclodesulfurization process which allows for the efficient synthesis of these scaffolds at 60 °C of reaction temperature without the addition of a transition metal‐catalyst or hazardous solvents with excellent yields (up to 92 %) of product formation. This process involves HFIP‐mediated hydrogen bonding interactions with the hydroxyl and thiol moieties, leading to bond breaking and formation during the reaction, resulting in the compounds of interest and the in situ release of H2S gas.
Imaging Neurotransmitters with Small‐Molecule Fluorescent Probes
Authors: Bade Anusha , Yadav Peeyush , Zhang Le , Naidu Bypaneni Ramesh , Xu Ming , Glass Timothy E. 
Published: June 2024

AbstractNeurotransmitters play a crucial role in regulating communication between neurons within the brain and central nervous system. Thus, imaging neurotransmitters has become a high priority in neuroscience. This minireview focuses on recent advancements in the development of fluorescent small‐molecule fluorescent probes for neurotransmitter imaging and applications of these probes in neuroscience. Innovative approaches for probe design are highlighted as well as attributes which are necessary for practical utility, with a view to inspiring new probe development capable of visualizing neurotransmitters.
Intimate partner violence and Bowen family systems theory: promoting safety and expanding capacity of families
Authors: Burke Katherine , Post Amie 
Published: June 2024

AbstractFamily violence is becoming increasingly visible in Australia, with many state and federal governments taking on more responsibility to address family violence and its impacts on those affected. Current efforts are focused on practice frameworks, identifying and responding to risk factors, and social justice frameworks including legislating against family violence in a range of jurisdictions and addressing more broadly the structural and cultural forces that perpetuate violence and further oppress those victimised. Family violence is not unique to Australia, with prevalence rates internationally suggesting family violence occurs irrespective of country, race, age, culture, effectiveness of social policies or socioeconomic status. This paper explores relevant foundational concepts of Bowen family systems theory (BFST) as it relates to family violence and explores opportunities to evolve practice in this area. BFST offers a unique contribution towards addressing family violence, particularly in relation to the public health challenge of addressing family polyvictimisation. The paper also explores how BFST conceptualises family violence and the role of the professional in working with the family as a single emotional unit. The unique focus of BFST on observing and defining self within the emotional family unit through observation of the underlying multigenerational emotional patterns of functioning provides unique opportunities to evolve and develop both the capacity of clinicians and responses to families who are navigating the serious and challenging impacts of family violence.
Work “for” you or work “with” you: The effect of candidate's positioning on donation reception
Authors: Ho Cony Ming‐Shen 
Published: June 2024

AbstractDonations are a well‐studied area in consumer research, but our understanding of political donations is limited. Because the motivations for donating to charity and political candidates are different, we use branding perspectives to investigate this important phenomenon. In four studies, we demonstrate that candidates with a “servant” brand positioning are likely to generate fewer donations compared with those with a “partner” positioning. This is because a servant brand positioning leads individuals to perceive that the candidates require fewer resources. We also show that the relationship between brand positioning and political donation is influenced by factors such as political ideology, election polls, and the percentage of the donation relative to election expenses. Specifically, the effect is stronger among conservatives, when the candidates are leading in the polls, and when a small donation represents a significant portion of the election expenses. These findings provide valuable insights into how brand positioning affects individuals' intentions to donate to political campaigns.
Identification of Orthosteric and Allosteric Pharmacological Chaperones for Mucopolysaccharidosis Type IIIB
Authors: Losada Juan Camilo , Triana Heidy , Vanegas Egdda , Caro Angela , Rodríguez‐López Alexander , Espejo‐Mojica Angela Johana , Alméciga‐Diaz Carlos Javier 
Published: June 2024

AbstractMucopolysaccharidosis type IIIB (MPS IIIB) is an autosomal inherited disease caused by mutations in gene encoding the lysosomal enzyme N−acetyl‐alpha‐glucosaminidase (NAGLU). These mutations result in reduced NAGLU activity, preventing it from catalyzing the hydrolysis of the glycosaminoglycan heparan sulfate (HS). There are currently no approved treatments for MPS IIIB. A novel approach in the treatment of lysosomal storage diseases is the use of pharmacological chaperones (PC). In this study, we used a drug repurposing approach to identify and characterize novel potential PCs for NAGLU enzyme. We modeled the interaction of natural and artificial substrates within the active cavity of NAGLU (orthosteric site) and predicted potential allosteric sites. We performed a virtual screening for both the orthosteric and the predicted allosteric site against a curated database of human tested molecules. Considering the binding affinity and predicted blood‐brain barrier permeability and gastrointestinal absorption, we selected atovaquone and piperaquine as orthosteric and allosteric PCs. The PCs were evaluated by their capacity to bind NAGLU and the ability to restore the enzymatic activity in human MPS IIIB fibroblasts These results represent novel PCs described for MPS IIIB and demonstrate the potential to develop novel therapeutic alternatives for this and other protein deficiency diseases
Lysophosphatidylcholine induces oxidative stress and calcium‐mediated cell death in human blood platelets
Authors: Yadav Pooja , Beura Samir K. , Panigrahi Abhishek R. , Kulkarni Paresh P. , Yadav Mithlesh K. , Munshi Anjana , Singh Sunil K. 
Published: June 2024

AbstractPlatelets are essential component of circulation that plays a major role in hemostasis and thrombosis. During activation and its demise, platelets release platelet‐derived microvesicles, with lysophosphatidylcholine (LPC) being a prominent component in their lipid composition. LPC, an oxidized low‐density lipoprotein, is involved in cellular metabolism, but its higher level is implicated in pathologies like atherosclerosis, diabetes, and inflammatory disorders. Despite this, its impact on platelet function remains relatively unexplored. To address this, we studied LPC's effects on washed human platelets. A multimode plate reader was employed to measure reactive oxygen species and intracellular calcium using H2DCF‐DA and Fluo‐4‐AM, respectively. Flow cytometry was utilized to measure phosphatidylserine expression, mitochondrial membrane potential (ΔΨm), and mitochondrial permeability transition pore (mPTP) formation using FITC‐Annexin V, JC‐1, and CoCl2/calcein‐AM, respectively. Additionally, platelet morphology and its ultrastructure were observed via phase contrast and electron microscopy. Sonoclot and light transmission aggregometry were employed to examine fibrin formation and platelet aggregation, respectively. The findings demonstrate that LPC induced oxidative stress and increased intracellular calcium in platelets, resulting in increased phosphatidylserine expression and reduced ΔΨm. LPC triggered caspase‐independent platelet death and mPTP opening via cytosolic and mitochondrial calcium, along with microvesiculation and reduced platelet counts. LPC increased the platelet's size, adopting a balloon‐shaped morphology, causing membrane fragmentation and releasing its cellular contents, while inducing a pro‐coagulant phenotype with increased fibrin formation and reduced integrin αIIbβ3 activation. Conclusively, this study reveals LPC‐induced oxidative stress and calcium‐mediated platelet death, necrotic in nature with pro‐coagulant properties, potentially impacting inflammation and repair mechanisms during vascular injury.
Nitrophenol Reduction with Silver Oxide Nanostructures as a Sustainable Approach to Environmental Remediation
Authors: Ivan Jebakumar D. S. , Robinson Richard V. , Subramanian T. , Rajakani V. 
Published: June 2024

AbstractWe propose silver oxide as a cost‐effective and sustainable alternative to noble metals for the catalytic reduction of nitroaromatics. In the present investigation, we adopt a facile and green synthetic route for the synthesis of silver oxide nanostructures. The prepared nanostructures were found to crystallize in the cuprite phase and exhibit absorbance across the entire visible range of the electromagnetic spectrum. The catalytic potential of the silver oxide was evaluated by following the kinetics of nitrophenol reduction under ambient conditions and is observed to follow pseudo‐first order kinetics with the apparent rate constant
s−1 at minimum concentration of the catalyst. We attribute the observed catalytic activity to the freshly generated catalytic surface featuring a partially reduced form of silver oxide during reaction. The findings highlight the efficacy of silver oxide in mitigating the environmental pollution originating from the recalcitrant nitroarenes.
A General Protocol toward Oxindoles Bearing C3‐Allylic Quaternary Stereocenter via Domino Reaction: A Concise Synthesis of Heterocycle‐Fused Indoline Alkaloids
Authors: Yang Hanxiao , Fan Ruoqian , Wen Daheng , Fan Mengmeng , Fang Weiwei 
Published: June 2024

Comprehensive SummaryAn efficiently catalytic method toward the synthesis of indolin‐2‐ones featuring an allylic derived C3‐quaternary stereocenter via an intramolecular Heck cyclization/Suzuki coupling of N‐substituted‐N‐(2‐bromophenyl)acrylamides and organoboron reagents was successfully developed by using a 1,3‐bis(2,6‐diisopropylphenyl)acenaphthoimidazol‐2‐ylidene (AnIPr)‐ligated oxazoline palladacycle. It enabled a very broad substrate scope tolerating different functional groups, electronic properties and steric bulkiness. Notably, it revealed a great potential to build diverse heterocycle‐fused indoline alkaloids via the same intermediate 3‐allyl‐1,3‐dimethylindolin‐2‐ one.
Intermediate Intercluster Bond Orders. Electronic Communication in Au38(SR)24 Superatomic Molecules
Authors: Rodríguez‐Kessler Peter L. , Muñoz‐Castro Alvaro 
Published: June 2024

AbstractLigand‐protected gold clusters remain potential building blocks for envisaged molecular materials. The archetypal Au38(SR)24 cluster can be viewed as a robust template for the fusion of two Au25(SR)18− cluster units, retaining a bi‐icosahedral Au23 core. Via electrochemical properties, the overall charge state can be selectively tuned, enabling the access of 14 valence electron (ve) species featuring a single intercluster bond and nearby charge from −1 to +3, achieving related species bearing 15‐ to 11‐ve with variable intercluster bond orders. Here, we explore the characteristics of intermediate intercluster bond orders in order to provide insights into the plausible electron communication between the constituent building blocks, with Au38(SR)24, as a representative template. Our results denote a small structural variation along −1 to +3 charge states, provided by the core‐protecting ligand interaction, which is enhanced towards more oxidized species. The remaining unpaired electron from intermediate intercluster bond orders of 1.5 for Au38(SR)241−, 1.5 for Au38(SR)241+, and 2.5 for Au38(SR)243+, holds delocalized characteristics between the building block units, favoring electron communication for conductive and cooperative cluster aggregates. Such features are relevant for the formation of molecular electronic device applications, favoring the rationalization prior to engaging in explorative synthesis of larger ligand‐protected cluster aggregates.
Quantification of the Donor‐Acceptor Character of Ligands by the Effective Fragment Orbitals
Authors: Comas‐Vilà Gerard , Salvador Pedro 
Published: June 2024

AbstractMetal‐ligand interactions are at the heart of transition metal complexes. The Dewar‐Chat‐Duncanson model is often invoked, whereby the metal‐ligand bonding is decomposed into the simultaneous ligand→metal electron donation and the metal→ligand back‐donation. The separate quantification of both effects is not a trivial task, neither from experimental nor computational exercises. In this work we present the effective fragment orbitals (EFOs) and their occupations as a general procedure beyond the Kohn‐Sham density functional theory (KS‐DFT) framework for the identification and quantification of donor‐acceptor interactions, using solely the wavefunction of the complex. Using a common Fe(II) octahedral complex framework, we quantify the σ‐donor, π‐donor, and π‐acceptor character for a large and chemically diverse set of ligands, by introducing the respective descriptors σd, πd, and πa. We also explore the effect of the metal size, coordination number, and spin state on the donor/acceptor features. The spin‐state is shown to be the most critical effect, inducing a systematic decrease of the sigma donation and π‐backdonation going from low spin to high spin. Finally, we illustrate the ability of the EFOs to rationalize the Tolman electronic parameter and the trans influence in planar square complexes in terms of these new descriptors.
Purification of Adeno‐Associated Viral Vector Serotype 9 Using Ceramic Hydroxyapatite Chromatography and its Analysis
Authors: Kurosawa Yae , Tsunekawa Yuji , Wada Mikako , Aizen Yuko , Nitahara‐Kasahara Yuko , Okada Takashi 
Published: June 2024

AbstractAdeno‐associated virus (AAV) vectors can efficiently transduce exogenous genes into various tissues in vivo. Owing to their convenience, high efficiency, long‐term stable gene expression, and minimal side effects, AAV vectors have become one of the gold standards for investigating gene functions in vivo, especially in non‐clinical studies. However, challenges persist in efficiently preparing a substantial quantity of high‐quality AAV vectors. Commercial AAV vectors are typically associated with high costs. Further, in‐laboratory production is hindered by the lack of specific laboratory equipment, such as ultracentrifuges. Therefore, a simple, quick, and scalable preparation method for AAV vectors is needed for proof‐of‐concept experiments. Herein, we present an optimized method for producing and purifying high‐quality AAV serotype 9 (AAV9) vectors using standard laboratory equipment and chromatography. Using ceramic hydroxyapatite as a mixed‐mode chromatography medium can markedly increase the quality of purified AAV vectors. Basic Protocols and optional methods for evaluating purified AAV vectors are also described. © 2024 The Author(s). Current Protocols published by Wiley Periodicals LLC.Basic Protocol 1: Production of AAV9 vectors in 293EB cellsBasic Protocol 2: Concentration and buffer exchange of AAV9 vectors from 293EB cell culture supernatants using tangential flow filtrationBasic Protocol 3: Purification of AAV9 vectors from TFF samples using ceramic hydroxyapatite chromatographyBasic Protocol 4: Analysis of the purified AAV9 vectors
Structure, Characterizations, Photocurrent Response, and Theoretical Study of One Chained Hybrid Iodoplumbate
Authors: Xie Shuyue , Wu Jinting , Li Baohan , Liu Huicong , Wang Hao , Li Jun , Zhang Bo 
Published: June 2024

AbstractExploring new haloplumbate hybrids and understanding the structure‐activity relationships are of great significance for further promoting their applications in the photovoltaic fields. Herein, with the in situ‐formed [Hmd]+ (md = 2‐methyl‐1,3‐diazinane) templates, a new organic–inorganic hybrid iodoplumbate, namely [Hmd]PbI3 (1), is successfully constructed and then structurally characterized using multiple technical approaches. X‐ray crystallography studies show that compound 1 features the typical 1D chain‐like motifs of [Pb2I6]n2n−, generating the 3D supermolecular network by the extensive hydrogen bond interactions. Interestingly, compound 1 exhibits the semiconductive behavior, with an optical band gap of 2.72 eV. More attractively, the title compound has good photoelectric switching performances under the alternating light irradiation, whose photocurrent densities compete well with or surpass those of many metal halide counterparts. Further theoretical analyses reveal that the title compound has a more dispersive band structure (especially the value band) that facilitates the transport of charge carriers, which may be the main origin of its excellent optoelectronic performance. Presented in this paper also bring the studies of Hirshfeld surface, X‐ray photoelectron spectroscopy (XPS) as well as thermogravimetric analysis.
Two‐Dimensional Copper‐Based Metal‐Organic Framework for Efficient Removal of Methylene Blue from Wastewater
Authors: Li Shixiong , Huang Lanci , Guo Wei , Feng Xiaojing , Cao Yuzheng , Liao Beiling 
Published: June 2024

AbstractMetal‐organic frameworks (MOFs) can effectively remove methylene blue (MB) from wastewater due to their abundant adsorption sites and multi‐level pores. In this paper, a copper‐based MOF: {[Cu ⋅ (L) ⋅ (H2O)] ⋅ (DMF)}n (1) (H2L=2‐hydroxyterephthalic acid; DMF=N,N‐dimethylformamide), was synthesized by hydrothermal synthesis method. X‐ray single crystal diffraction showed that a two‐dimensional structure was formed by the carboxyl group of L2− in 1 took μ2‐η1 : η1 bridged two adjacent Cu(II). In this two‐dimensional structure, the coordinated water molecules and hydroxyl group on L2− were distributed on the surface of 1. Thus, it had abundant adsorption sites. The transmission electron microscopy (TEM) of copper‐based MOF nano adsorbent showed that the particle diameter of the nano adsorbent prepared by a cell fragmentation apparatus was about 50 nm. The performance of the copper‐based MOF nano adsorbent in adsorbing MB indicated that the optimal adsorbent dosage was 0.20 g/L and the solution pH was 6. Under the optimal experimental conditions, its maximum adsorption capacity for MB was 143.3 mg/g, which was superior to most MOFs adsorbents. The adsorption thermodynamic analysis showed that the copper‐based MOF nano adsorbent at 25–45 °C was an exothermic (ΔH<0), and spontaneous (ΔG<0) process.