bluuebunny/crossref_metadata_2025_split huggingface dataset:
A theoretical study on a new drug combines between vanadyl sulfate and vitamin E in a single component: A novel antioxidant medication in female reproductive health
Authors: Mohammed Alsuhaibani Amnah , Hassan AlShawi Amal , Gaber Ahmed , Shakya Sonam , S. Refat Moamen 
Published: May 2024

This study explores the theoretical properties of a novel complex formed by combining vitamin E (VitE) and vanadyl(II) sulfate. The complex, [VO(VitE)2(H2O)2]2H2O (Vcom), was synthesized in solid form through a reaction between VitE and VOSO4.xH2O in a specific solvent mixture and pH. VitE binds to the vanadyl ion as a single ligand via its deprotonated phenolic oxygen. To characterize the complex, various analytical techniques were employed, including elemental analysis, spectral analysis, conductivity measurements, thermal analysis, X-ray diffraction, and microscopy. Electronic and magnetic properties were also investigated. Theoretical calculations - molecular docking simulations were used to assess the binding affinity of Vcom with two receptors known to interact with vitamin E: α-tocopherol transfer protein (α-TTP) and p105 subunit of nuclear factor NF-kappa-B p105 subunit (NF-κB). The findings revealed a square pyramidal geometry for the Vcom complex. Additionally, Density Functional Theory (DFT) were performed on both VitE and Vcom, focusing on their optimized structures, electrostatic properties, and HOMO-LUMO energy gaps. In summary, this research delves into the theoretical aspects of a newly formed VitE-vanadyl complex, providing insights into its structure, properties, and potential interactions with relevant receptors.
KEY WORDS: New drug, Vanadyl sulfate, Vitamin E, Antioxidant, Female, Reproductive health, DFT
Bull. Chem. Soc. Ethiop. 2024, 38(4), 989-1001.
DOI: https://dx.doi.org/10.4314/bcse.v38i4.14
Synthesis of bioactive heterocyclic compounds using camphor
Authors: Sultan Alwan Ensaf , Milad Mohareb Rafat 
Published: May 2024

The aim of the work was to synthesize novel heterocyclic compounds derived from camphor with antibacterial activity. The pyridazine, xanthene, pyranothiazole, pyridinothiazole, thiophene and pyrazole derivatives were produced from 4,11,11-trimethyl-9-phenyl-7-(2-phenylhydrazono)-3,4,5,6,7,9-hexahydro-1H-1,4-methanoxanthen-8(2H)-one (1). Thiophene derivatives 6a,b were produced according to the Gewald’s reaction for thiophene synthesis. On the other hand, pyranothiazol derivatives 8a,b were synthesized by the multicomponent reactions between xanthene derivative 5, benzaldehyde and ethylcyanoacetate or malononitrile in ethanol/triethylamine. Whereas, pyridinothiazole derivative 9 was produced in ethanol/ammonium acetate by the multicomponent reaction between xanthene derivative 5, benzaldehyde and malononitrile. The antibacterial activity of the synthesized compounds was evaluated against E. coli bacteria. All synthesized compounds showed moderate activity against E. coli bacteria.
KEY WORDS: Anti-microbial, Camphor, Heterocyclic, Pyrazol-3(2H)-one, Thiazol-4(5H)-one, Thieno[3,2-d]thiazole, Xanthenes
Bull. Chem. Soc. Ethiop. 2024, 38(4), 1069-1076.
DOI: https://dx.doi.org/10.4314/bcse.v38i4.20
Cerric ammonium nitrate catalyzed eco-friendly green synthesis of chitosan Schiff base using PEG-400 as an anticancer agent against gastric cancer cells via inhibiting EGFR
Authors: Geng Wei , Feng Xinwei , Li Chunfeng , Ni Sifeng 
Published: May 2024

The present study was conducted to scrutinize the pharmacological effect of oxazole-embedded Chitosan as an anticancer agent against gastric cancer cells. This compound was synthesized using the classical Schiff base reaction but utilizing the novel green chemical process where cerric ammonium nitrate (CAN) was used as a catalyst in the PEG-400 as solvent media. The target compound was obtained with an excellent yield at the catalyst loading of 5% CAN concentration in 15 min. The Kinase-Glo Plus luminescence kinase assay kit was used to determine the EGFR inhibitory activity of compound 1 where it showed potent activity with IC50 of 2.14 µM. Its effect was also determined on the cellular viability of the Human gastric cancer cell line (SGC7901), liver cancer cell line (HepG2), and lung cancer cell line (A549), where it exhibits potent activity against SGC7901. The compound further showed the concentration-dependent inhibitory effect on migration and invasion of SGC7901. In RT-qPCR analysis, the compound showed induction of apoptosis of SGC7901 cells possibly by restoring the expression of Bcl-2 and Bax near to normal, and inhibition of the mRNA expression of EGFR in a concentration-dependent manner.
KEY WORDS: Schiff base, Chitosan, EGFR, mRNA, apoptosis, Bcl-2
Bull. Chem. Soc. Ethiop. 2024, 38(4), 1091-1101.
DOI: https://dx.doi.org/10.4314/bcse.v38i4.22
TCS/ZnCl2 as a controlled reagent for the Michael addition and heterocyclic cyclization based on the phenyl pyrazolone scaffold with docking validation as a Covid-19 protease inhibitor
Authors: A. Almehizia Abdulrahman , M. Naglah Ahmad , A. Zen Amer , K.  Khatab Tamer , S. Hassan Ashraf 
Published: May 2024

TCS/ZnCl2 is presented as a new catalyst for achieving the Michael addition adduct 5a-g by the reaction of phenyl pyrazolone 4 as the Michael donor and arylidene derivatives 3a-g as the Michael acceptor. The one-pot multi-component reaction of the same fragments' scaffolds as aldehydes 1a-g, malononitrile (2), and phenyl pyrazolone 4 with the same catalyst gives pyrano[2,3-c]pyrazole derivatives 6a-g as final products. The prepared compounds undergo docking validation as COVID-19 protease inhibitors and are compared with hydroxychloroquine as a reference drug.
KEY WORDS: Pyranopyrazole, multi-component reactions, TCS/ZnCl2 catalyst, COVID-19, the energy score, hydroxychloroquine
Bull. Chem. Soc. Ethiop. 2024, 38(4), 1119-1127.
DOI: https://dx.doi.org/10.4314/bcse.v38i4.24
Synthesis of new peptide-based macrocycles: Evaluation of their in vitro anti-proliferative activity and molecular dynamic simulation studies
Authors: O. Moustafa Gaber , A. Almehizia Abdulrahman , A. Al-Omar Mohamed , M. Al-Obaid Abdulrahman , M. Naglah Ahmed , A. Zen Amer 
Published: May 2024

A simplified synthetic protocol was adopted for the preparation of the six novel cyclo-pentapeptide candidates of the structure cyclo-(m-phthaloyl)-bis-[L-Phe -Gly/Sar]-L-Lys–X, where X = COOMe (9a,b), COOH (10a,b) and NHNH2 (11a,b). The potential cytotoxicity (IC50, μg/mL) for cyclo-pentapeptides (9a,b), (10a,b), (11a,b) and doxorubicin® as reference drugs, is assayed against eight cell lines of human cancer namely; mamillary MCF-7 and T47D, hepatic HEPG2, colon HCT116, cell line of cervix HELA, larynx HEP2, Prostate PC3, and gut Caco. Cyclo-[m-phthaloyl chloride-bis-(L-phalanine-sar)-L-Lys]-COOH 10b was proved as cytotoxically more potent than doxorubicin against most of the screened cell lines. It can be inferred that the proposed molecular structural characteristics associated with cytotoxicity in these m-phthaloyl-bridged cyclopeptides appear noteworthy and hold promise as potential candidates for further exploration as novel anticancer agents. Molecular dynamics simulation studies of 10b into the binding site of Human Epidermal Growth Factor Receptor tyrosine kinase exhibited the highest MM-GBSA value (-16.59 kcal/mol).
KEY WORDS: Anticancer, Cytotoxicity, Cyclopeptides, Cyclopeptides, m-phthaloyl-bis-peptides
Bull. Chem. Soc. Ethiop. 2024, 38(4), 1129-1144.
DOI: https://dx.doi.org/10.4314/bcse.v38i4.25
Study on the engine characteristics (CI) of using pumpkin-maize-blended biodiesel mixed with additive (diethyl ether)
Authors: Magesh N. , Pushparaj T. , Sabanayagam S. 
Published: May 2024

This paper focused on the engine characteristics of a diesel engine fuelled using ternary blends. Initially, pumpkin and maize biodiesel were mixed in a volume ratio of 50:50. With a constant 0.5% diethyl ether (DEE) content, the binary combination of pumpkin and maize biodiesel was mixed with diesel at proportions of 10:90, 20:80, 30:70, 40:60, and 50:50 by volume. The prepared ternary mixtures were evaluated at varying engine loads to improve engine performance. Compared to diesel, the tested ternary blends had a reduced brake thermal efficiency (BTE). However, up to a 30% blending ratio, the BTE demonstrated by ternary blends was within the range of less than 0.5% concerning diesel fuel. The ternary blends' BSFC declined as the binary biodiesel mix increased. Diesel has a brake specific fuel consumption (BSFC) of 1.4%, 2.2%, and 3.4% lower than the ternary blends of 10%, 20%, and 30%. The decrease in the heat release rate of the ternary mixes meant that emitted less CO and NOx than diesel. In contrast, ternary blends exhibited an increasing trend in smoke and HC emissions because of the rise in incomplete combustion that occurs as biodiesel content rises. Therefore, with appropriate engine modifications, the pumpkin and maize binary biodiesel blend can replace diesel by up to 30%.
KEY WORDS: Biodiesels, Binary blend, DEE, Ternary blend, Efficiency
Bull. Chem. Soc. Ethiop. 2024, 38(4), 1145-1161.
DOI: https://dx.doi.org/10.4314/bcse.v38i4.26
Polyaniline/TiO2 nanocomposite for high performance supercapacitor
Authors: H. Mahmoud Zaid , Kamil Ghadir Ghadir , Musaad Al-Tmimi Hayder , Jasim Al-Shuwaili Saeb , Ali Ami Ahmed , Kadem Radi Usama , Mustafa Hameed Safaa , Ahmed Mustafa Mohammed 
Published: May 2024

A binary polyaniline/TiO2 and varied weight ratio TiO2/PANI nanocomposite was successfully fabricated as an electrode for energy storage application. The TiO2 nanoparticles were synthesized via manual irradiation system with wavelength 256 nm and power 125 W. Polyaniline/TiO2 was then prepared by in situ polymerizing TiO2 onto aniline monomer. Polyaniline nanofibers are loaded with TiO2 to product core-shell system. The polyaniline/TiO2 nanocomposite were characterized using XRD, XPS, TEM, TGA, CP and LCR measurements. The structure properties were examined by XRD and XPS, which confirmed preparing polyaniline/TiO2 binary nanocomposite. The thermal stability was investigated using TGA and obtained high stability of polyaniline/TiO2 compared with polyaniline, while the electrochemical properties were examined by LCR measurements. The LCR measurements were appeared dielectric constant and dielectric loss for incorporating TiO2 through PANI. Varied weights ratio TiO2 was worked in increasing the stored energy ability of polyaniline. Notably, the electrochemical investigate results appear that the PANI/TiO2 has a high specific capacitance (250 F/g) compared with pure PANI (200 F/g).
KEY WORDS: Supercapacitor, UV irradiation, XPS, LCR, nanofibers
Bull. Chem. Soc. Ethiop. 2024, 38(4), 1177-1188.
DOI: https://dx.doi.org/10.4314/bcse.v38i4.28
A Historical-Analytic Perspective on Islam and Cinematic Culture in Northern Nigeria
Authors: Banjo Rukayat N. 
Published: May 2024

This article reviewed the intricate relationship between film/cinematic culture and Islam in northern Nigeria and more importantly, the reception of film as a culture in Hausa Muslim societies. Various media ethnographical studies have revealed that since the introduction of cinema, the acceptance and consumption of film and other cinematic products are to a large extent influenced by the Sharia (Holy/ Islamic Law), which serves as a guide for northern filmmakers and a corrective measure for the media representations of the happenings in their societies. The belief of northern Muslims is that films and cinema are harbingers of immorality and should be eschewed. Indeed, and arguably so, this is the general disposition of the northern Muslims to western ways. The overwhelming exertions of the Kano State Film and Video Censors Board (KSCB) make this claim evident. This study considered the mobility and survival of cinematic culture in the heart of Nigeria’s most Islamic centre, Kano, otherwise known as Kannywood. It adopted a historical-analytic approach to the study of the development of cinema in northern Nigeria and examined the cinematic culture vis-à-vis Islam in northern Nigeria. The paper contended that globalisation and the advent of advanced technology are yet to influence film contents from the region or mass acceptance and consumption of modern films by its populace. It concluded that the Sharia and the involvement of Islamic scholars/clerics have inhibited the growth of Kannywood.
Sense and Sensibility: The Politics of Representation in Chimamanda Adichie’s <i>Half of a Yellow Sun</i>
Authors: Lakanse Obakanse Olusegun 
Published: May 2024

No literary enterprise is as complex and challenging as writing a novel on civil war, especially in a postcolonial, multi-ethnic society. It is a narrative that often generates very contentious views, and so requires a very nuanced and complex telling. It is the contention of this article that Chimamanda Adichie must have realised the complex and difficult nature of her task when she was writing Half of a Yellow Sun (Half), hence, her attempt at some historical nuance and ambivalence in the novel. Therefore, this paper attempts a deconstruction of Adichie’s methods and styles in Half of a Yellow Sun and highlights some of the challenges and perspectival difficulties she must have encountered while she was writing the novel. The paper also highlights some of her lapses, silences and evasions. It concludes that there is something Adichie deftly inters in the roles and assertions she ascribes to her characters and in the way she has shaped her narrative that seems to indicate not only how ethnicity permeates and structures everything we do and represent in the country but also how the question of ethnicity has seldom been made a subject of self-scrutinising reflection in public discourse.
Outbreak Of Fowlpox In Commercial Brown Pullets Previously Vaccinated With Fowlpox Vaccine In Zaria, Kaduna State, Nigeria
Authors: Umar B.N. , Ahmad M.T. , Ungogo M.A. 
Published: May 2024

Fowlpox is a contagious viral disease of poultry, ranked as the third most important cause of mortality in Nigerian indigenous chickens. The present study confirms an outbreak of fowlpox in a flock of 500 Isa brown, 11-weeks-old pullets in Zaria, Kaduna State, Nigeria. The pullets were managed under deep litter system and previously vaccinated with live attenuated vaccine (ABIC biological laboratories Ltd. Israel) at 8-weeks old. They had gross lesions suggestive of cutaneous fowlpox on skin of the head region with 58% morbidity but persistent low mortality rate of 13.8%. Fowlpox virus was isolated from the cutaneous lesions using chorioallantoic membrane (CAM) inoculation in 9 to 11-day-old embryonated chicken eggs based on the presence of opaque-white pock lesions, then confirmed by Agar Gel Immuno Diffusion test using homologous known fowlpox virus (antigen) and antisera. Specific antibodies to fowlpox virus were quantified from the sera of the chickens using an indirect ELISA (Abbkine, Inc, China). The case was managed using; Intramuscular injection of oxytetracycline (TLA), topical applications of oxytetracycline spray as well as oral administrations of Doxygen® and vitamins. Apparently healthy chickens were revaccinated against fowlpox and the pen was thoroughly cleaned, washed, and disinfected. This report had shown an occurrence of vaccine failure, alongside a promising management option and highlighted the significance of vaccination with strict biosecurity measures in the control of fowlpox in Nigeria.
Análisis de riesgos en el almacén de materiales, y la utilización de tecnologías para la adecuada gestión de inventarios área de: Medición, Conexiones y Servicios de la Comisión Federal de Electricidad
Authors: Valdez Guerrero Raquel , Valencia Lucero Paola Gabriela , Robles Arias Isela Margarita , Ríos Calderón Graciela Guadalupe 
Published: May 2024

La gestión adecuada de materiales dentro de la organización implica riesgos, derivado de la importancia del control interno en la administración, por lo que requiere atención especial. Su diseño debe considerar la consecución de objetivos de la organización, así como la sustentabilidad, integrado en ello la generación de equilibrio, el valor de los empleados, consumidores y la sociedad, en relación a las operaciones que se ejecutan en el área, el grado de seguridad y la gestión de información. La Comisión Federal de electricidad Zona La Paz, B.C.S. tiene como misión: Suministrar insumos y bienes energéticos requeridos para el desarrollo productivo y social de la localidad de forma eficiente, sustentable, económica e incluyente, mediante una política que priorice la seguridad y la soberanía energética nacional y fortalezca el servicio público de electricidad. Esta compañía tiene grandes retos en la península de B.C.S., por el gran desarrollo que se ha presentado en tiempos recientes de acuerdo a datos proporcionados por el Instituto Nacional de estadística y geografía (INEGI), ha sido uno de los estados con mayor crecimiento en el país. Para la compañía representa un gran reto el poder atender la creciente demanda de energía, a saber: control interno de materiales y gestión inventarios. Para el estudio se considera el marco referencia de la problemática presentada, la metodología de acuerdo al Modelo COSO III, con aplicación de diagnóstico para hacer el análisis de los riesgos y determinación de la tecnológica adecuada para su aplicación en la gestión del control de los inventarios.
Metodología para la aplicación de resultados investigativos en la práctica de las empresas locales
Authors: Larrea Jústiz Raúl 
Published: May 2024

Basado en experiencias prácticas y de investigación en las empresas con enfoque a clientes, se presenta una metodología para la difusión e introducción de los resultados investigativos universitarios en la práctica empresarial, transfi riendo los conocimientos que en particular se han logrado con la elaboración de tesis de maestría. Se ha identifi cado que las empresas locales no siempre están al tanto de métodos y técnicas experimentadas con éxito en otros países, publicadas en revistas, libros y reportes, así como estudiadas y ejercitadas durante los estudios de postgrado de la universidad. Es un modo concreto de vincular a la universidad con un sector de la sociedad tan importante como es el empresarial. En el artículo se presenta un sistema de trabajo que representa un fl ujo continuo de construcción de conocimiento, que permite mejorar la comprensión de la realidad empresarial,
y proponer alternativas de solución con uso de los métodos y técnicas referidos.
Crisis económica en Estados Unidos, en la última década y su impacto en el resto del mundo
Authors: Cabanilla Guerra Galo , Cabanilla Guerra Mara 
Published: May 2024

El artículo que se somete a consideración del lector es el resultado de un amplio y profundo proceso de investigación histórica, llevado a cabo por los autores, por más de 10 años; el mismo busca mostrar de qué manera nuestras economías se han visto afectadas a lo largo de estos diez años por las reiteradas fases de crisis que ha soportado Estados Unidos y llevar a refl exión lo que está pasando actualmente en el mundo. Las sucesivas crisis en las diferentes economías y la profundización de una crisis mundial que hasta el momento continua, nos dejan graves cuestionamientos sobre la viabilidad económica para nuestros países de algunos de los postulados sobre los mercados abiertos. Si bien las motivaciones para las crisis dependen de las características podemos confirmar una mayor interrelación del sistema económico mundial desde hace mucho tiempo. Como una importante conclusión de este artículo se muestra que si bien muchos de los países, que por largos años se han considerado potencias mundiales en economía están dejando atrás esa imagen. En respuesta a esta situación otros países se están volviendo fuertes económicamente, en crecimiento y en desarrollo y sus monedas tienen cada día más peso en los mercados de valores y de divisas.
Budaya dan Amalan Ritual Kematian Ketua Komuniti (Ketaoh) Etnik Berawan
Authors: Mohd Salim Sara Shakila , Selamat Abu Zarrin , Naning Fatin Hana , Muhaidin Munirah , Magiman Mohamad Maulana 
Published: May 2024

Makalah ini bertujuan untuk mengkaji budaya ritual kematian komuniti etnik Berawan terhadap ketua komuniti (ketaoh). Upacara kematian kebiasaanya melibatkan pelbagai ritual dan istiadat yang berfungsi untuk mengimbangi dan mengukuhkan hubungan komuniti serta menyatakan nilai-nilai yang mencorak kehidupan mereka. Etnik Berawan dipilih sejajar dengan isu minoriti yang wujud pada masa kini yang merangkumi konteks keberterusan amalan kebudayaan yang dipegang serta diamalkan. Objektif utama kajian ialah mengkaji proses-proses ritual dan jenis-jenis simbol ritual dalam perlaksanaan pemakaman ketua komuniti etnik Berawan serta menilai prinsip sosial yang terkandung dalam ritual tersebut. Kajian ini menggunakan pendekatan etnografi berdasarkan kajian lapangan yang terdiri daripada temubual dan pemerhatian turut serta. Kajian lapangan ini juga disokong oleh sumber-sumber perpustakaan seperti buku, jurnal, dan kajian ilmiah yang relevan dengan bidang penyelidikan yang dijalankan. Hasil kajian menunjukkan bahawa budaya dan amalan ritual kematian ini berubah berdasarkan perubahan amalan dan kepercayaan agama yang dianuti kini dan pengaruh gaya hidup arus perdana. Kajian ini dijangka menyumbang kepada pengetahuan budaya etnik Berawan yang lebih bersifat mampan melalui penerbitan dan praktis.
The intensification of economic growth points as a tool for sustainable development of regions
Authors: Быкова М.Л. 
Published: May 2024

В статье анализируются приоритетные направления мезоэкономики, обеспечивающие социально-экономическое развитие субъектов Российской Федерации. Предложен подход к оценке точек экономического роста на примере субъектов Центрального федерального округа. Анализировались отрасти, занимающие наибольшую долю в структуре валового регионального продукта, а также рассматривалась динамика изменения структурных показателей валового выпуска.
The paper analyzes the priority areas of mesoeconomics that ensure the social development of the subjects of the Russian Federation. The study proposed an approach to assessing the points of economic growth using the example of the subjects of the Central Federal District. The industries that occupy the largest share in the structure of the gross regional product were analyzed, and the dynamics of changes in the structural indicators of gross output was also considered.
Assessment of the role of artificial intelligence in the sustainable development of the economy
Authors: Мирончук В.А. , Золкин А.Л. , Поскряков И.А. , Маринов А.Д. 
Published: May 2024

В статье исследуются возможности искусственного интеллекта и его влияние на некоторые сферы экономики. В современных реалиях искусственный интеллект занимает центральное положение и является одной из самых быстроразвивающихся областей. Он внедряется почти во все сферы общественной жизни: образование, предпринимательство, медицина, экономика и т.д. Дано понятие искусственного интеллекта, выявлены пути его влияния на экономическое развитие, а также произведен анализ полученных результатов и их оценка.
The article explores the possibilities of artificial intelligence and its impact on some areas of the economy. In modern realities, artificial intelligence occupies a central position and is one of the fastest growing areas. Artificial intelligence is being introduced into almost all spheres of public life: education, entrepreneurship, medicine, economics, etc. In the course of the study, the concept of artificial intelligence was given, the ways of its influence on economic development were identified, and the results were analyzed and evaluated.