bluuebunny/crossref_metadata_2025_split huggingface dataset:
AVibrio choleraeAnti-Phage System Depletes Nicotinamide Adenine Dinucleotide to Restrict Virulent Bacteriophages
Authors: Woldetsadik Yishak A. , Lazinski David W. , Camilli Andrew 
Published: June 2024

AbstractBacteria and their predatory viruses (bacteriophages or phages) are in a perpetual molecular arms race. This has led to the evolution of numerous phage defensive systems in bacteria that are still being discovered, as well as numerous ways of interference or circumvention on the part of phages. Here, we identify a unique molecular battle between the classical biotype ofVibrio choleraeand virulent phages ICP1, ICP2, and ICP3. We show that classical biotype strains resist almost all isolates of these phages due to a 25-kb genomic island harboring several putative anti-phage systems. We observed that one of these systems, Nezha, encoding SIR2-like and helicase proteins, inhibited the replication of all three phages. Bacterial SIR2-like enzymes degrade the essential metabolic coenzyme nicotinamide adenine dinucleotide (NAD+), thereby preventing replication of the invading phage. In support of this mechanism, we identified one phage isolate, ICP1_2001, which circumvents Nezha by encoding two putative NAD+regeneration enzymes. By restoring the NAD+pool, we hypothesize that this system antagonizes Nezha without directly interacting with either protein and should be able to antagonize other anti-phage systems that deplete NAD+.
Social threat alters the behavioral structure of social motivation and reshapes functional brain connectivity
Authors: Velazquez-Hernandez Geronimo , Miller Noah W. , Curtis Vincent R. , Rivera-Pacheco Carla M. , Lowe Sarah M. , Moy Sheryl S. , Zannas Anthony S. , Pégard Nicolas C. , Burgos-Robles Anthony , Rodriguez-Romaguera Jose 
Published: June 2024

AbstractTraumatic social experiences redefine socially motivated behaviors to enhance safety and survival. Although many brain regions have been implicated in signaling a social threat, the mechanisms by which global neural networks regulate such motivated behaviors remain unclear. To address this issue, we first combined traditional and modern behavioral tracking techniques in mice to assess both approach and avoidance, as well as sub-second behavioral changes, during a social threat learning task. We were able to identify previously undescribed body and tail movements during social threat learning and recognition that demonstrate unique alterations into the behavioral structure of social motivation. We then utilized inter-regional correlation analysis of brain activity after a mouse recognizes a social threat to explore functional communication amongst brain regions implicated in social motivation. Broad brain activity changes were observed within the nucleus accumbens, the paraventricular thalamus, the ventromedial hypothalamus, and the nucleus of reuniens. Inter-regional correlation analysis revealed a reshaping of the functional connectivity across the brain when mice recognize a social threat. Altogether, these findings suggest that reshaping of functional brain connectivity may be necessary to alter the behavioral structure of social motivation when a social threat is encountered.
From Mutations to Disease: Computational Analysis and Interpretation of GPCR-Associated Pathogenicity
Authors: Velloso João Paulo L. , de Sá Alex G. C. , Ascher David B. 
Published: June 2024

ABSTRACTG protein-coupled receptors (GPCRs) perform critical roles in numerous physiological processes and their mutations are, therefore, associated with various human diseases. Hence, understanding the molecular consequences of pathogenic mutations in GPCRs is essential for elucidating disease mechanisms and developing effective therapeutic strategies. In this study, we employed computational approaches to explore the impact of mutations on GPCRs using two distinct datasets: ClinVar and MutHTP. We first evaluated the performance of available pathogenicity predictors. Beyond that, we used statistical analysis to identify key characteristics of mutations in GPCRs leading to diseases. We first evaluated available computational predictors, such as SIFT, PolyPhen-2, PROVEAN, ESM1b, and AlphaMissense in classifying GPCR mutations. During this task, we observed that all predictors performed with reliability when assessing GPCR mutations leading to diseases in the ClinVar dataset. On the other hand, when dealing with the MutHTP dataset, all predictors demonstrated poor performance, emphasising the importance of dataset characteristics and the need for comprehensive evaluation when selecting mutation predictive tools for GPCR analysis. The statistical analysis of mutations on GPCRs and disease development suggests that mutations occurring in conserved regions or regions with stronger intermolecular interactions are more likely to disrupt protein function and contribute to disease pathogenesis. Additionally, regarding our analysis, we also obtained insights into the importance of hydrophobic interactions and hydrogen bonding patterns in mutations in GPCRs and pathogenicity. Overall, our study enhances our understanding of the molecular mechanisms underlying GPCR-associated diseases and provides valuable insights for future research and clinical diagnostics in this field.
Digital solutions supporting the quality of life of European cancer patients and their caregivers: a systematic literature review
Authors: Ancona Camilla , Caroppo Emanuele , Lellis Pietro De 
Published: June 2024

AbstractPurposewe investigate (a) the diffusion of digital solutions supporting the quality of life in cancer patients and their caregivers across cancer types and EU countries, (b) the key thematic areas on which they focus, and (c) their effectiveness in improving the quality of life with respect to traditional healthcare.MethodsWe searched articles from Embase, Scopus and PubMed in the last decade, and assessed their quality according to mixed methods appraisal tool. We compared the effectiveness of such tools and discussed the main gaps that emerged.Results49 studies were included (31 quantitative randomized control trials, 9 quantitative non-randomized, 4 quantitative descriptive, 3 qualitative, and 2 mixed-methods). We observed a prevalence of studies from the Netherlands and Germany, and breast cancer patients are the most targeted by single-cancer type interventions. The key areas of interventions for e-health solutions are psychophysical well-being, management of physical distress, remote monitoring of vitals and symptoms, and empowerment and self-efficacy. The effectiveness of digital solutions is typically higher than traditional healthcare, especially for solutions focusing on psychosocial well-being.ConclusionsThis review showed a growing interest in digital solutions aimed at making the life of cancer patients and their caregivers easier, and their healthcare more patient-centered. The effectiveness of such interventions varies, but all the solutions are well accepted among the participants. Our findings provide evidence of the untapped potential of these digital tools, and of the need for their integration in the daily routine of cancer patients and their caregivers.
Laying the ground for future cross-organizational process mining research and application: a literature review
Authors: Rott Julian , Böhm Markus , Krcmar Helmut 
Published: June 2024

Purpose Process mining (PM) has emerged as a leading technology for gaining data-based insights into organizations’ business processes. As processes increasingly cross-organizational boundaries, firms need to conduct PM jointly with multiple organizations to optimize their operations. However, current knowledge on cross-organizational process mining (coPM) is widely dispersed. Therefore, we synthesize current knowledge on coPM, identify challenges and enablers of coPM, and build a socio-technical framework and agenda for future research.Design/methodology/approach We conducted a literature review of 66 articles and summarized the findings according to the framework for Information Technology (IT)-enabled inter-organizational coordination (IOC) and the refined PM framework. The former states that within inter-organizational relationships, uncertainty sources determine information processing needs and coordination mechanisms determine information processing capabilities, while the fit between needs and capabilities determines the relationships’ performance. The latter distinguishes three categories of PM activities: cartography, auditing and navigation.Findings Past literature focused on coPM techniques, for example, algorithms for ensuring privacy and PM for cartography. Future research should focus on socio-technical aspects and follow four steps: First, determine uncertainty sources within coPM. Second, design, develop and evaluate coordination mechanisms. Third, investigate how the mechanisms assist with handling uncertainty. Fourth, analyze the impact on coPM performance. In addition, we present 18 challenges (e.g. integrating distributed data) and 9 enablers (e.g. aligning different strategies) for coPM application.Originality/valueThis is the first article to systematically investigate the status quo of coPM research and lay out a socio-technical research agenda building upon the well-established framework for IT-enabled IOC.
Khalti: a digital wallet in Nepal
Authors: Dangol Pabitra 
Published: June 2024

Learning outcomes
After completion of the case study, the students will be able to understand competitive business and corporate strategies; understand various standard models and frameworks related to business and corporate strategy development such as Porter’s five forces model, Ansoff matrix, three value disciplines frameworks, scenario planning matrix and value chain analysis; and practice competitive strategy formulation using the latest analyzing tools/frameworks/models.

Case overview/synopsis
Although the digital wallet industry in Nepal was in its initial stage, it was growing rapidly. A digital wallet brand – Khalti, launched in 2017, could secure the second position in the industry within two years of establishment. In recent times, the leading digital wallet brand was eSewa which was developed by Kathmandu-based company – F1Soft International in 2009. Khalti team was better for creativity, risk-bearing capability, intact bond among co-founders, innovative skills and aggressive growth. Mr Amit Agrawal, the chief executive officer of Sparrow Pay Pvt. Ltd, was preparing to formulate some strategies for his company’s product, Khalti, on March 24, 2020. The next day, he was going to present his ideas about the future directions of Khalti with the co-founders of Janaki Technology, the parent company of Sparrow Pay Ltd. Therefore, his major agenda was how to design effective strategies to make Khalti more competitive against eSewa and probably lead the industry. Based on such a scenario, this case study deals with various competitive business and corporate strategies such as marketing, product and cost differentiation that Khalti could formulate to maintain its position and further become a leading firm in the industry.

Complexity academic level
This case study is suitable for business training programs at the master’s level, including Master of Business Administration and executive education. It is also appropriate for undergraduate students, particularly those who want to understand more about competitive business, strategic management and corporate strategy in developing economies. It is especially useful for students who have taken courses in strategic management, corporate strategy, marketing management and business expansion management. This case study is suitable for provoking skills of students such as critical and creative thinking, risk analysis and business planning.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS 11: Strategy
To “talk the walk” or to “walk the talk”? Employer branding and HRM synergies in small and medium-sized hotels
Authors: Zografou Irene , Galanaki Eleanna 
Published: June 2024

PurposeSome firms excel at positively presenting their employer brand (talk), while others excel at effectively implementing human resource management (HRM) practices for the benefit of the employees (walk). Which approach is more effective? Focusing specifically on small and medium-sized hotels (SMHs), this study explores the relation of employer branding (EB) and HRM practices with organizational performance (OP).Design/methodology/approachStratified sampling was used to identify 34 top management figures (owners, CEOs, and top HR managers) from SMHs across Greece. These individuals agreed to participate in in-depth, semi-structured, one-on-one interviews, focusing on their hotels’ HRM, EB, and organizational performance. The interviews were subjected to content analysis, further coupled with graphical exploration of the relations between the concepts under study.FindingsThe findings reveal a noteworthy pattern: high-performing SMHs tend to prioritize EB, particularly leveraging social media channels. This prioritization is further reinforced by the implementation of HRM practices, including extensive training and rewards. Clustering SMHs into four different levels based on their application of EB and HRM practices and the effect of these practices on OP, enables us to extend this study and gain valuable insights into the interplay of these factors.Practical implicationsThis study highlights the need for practitioners to invest in HRM practices, especially in training and rewards, while giving due attention to EB, despite the potential resource limitations SMHs often face. Importantly, when basic levels of HRM are combined with high levels of EB, OP seems to be maximized.Originality/valueBoth HRM and EB deal with the employer – employee interaction, that’s why EB in most companies is the responsibility of the HRM department. Surprisingly, academic research has treated them as distinct fields, in isolation, ignoring their combined effects. This paper is the first to conceptualize EB as communication (“talk”) and HRM as practice (“walk”) and to thus propose that a complementarity relationship between these two dynamics may facilitate OP. Additionally, this study is the first to combine content analysis with a quantitative exploration to gain more holistic and valuable insights on the topic.
Virtual active sports: identifying main barriers and facilitators for casual fitness fans
Authors: Evsikov Eugene , Hristova Velina , Vlaev Ivo , Karabeliova Sonya 
Published: June 2024

PurposeThe aim of this study is to utilise the Theoretical Domains Framework (TDF) to identify the main barriers and facilitators of positive attitude towards trying Virtual Active Sports (VAS).Design/methodology/approach200 individuals took part in an online cross-sectional survey based on 11 domains within the TDF. Linear logistic regression analysis was performed on the participant’s self-reported attitudes and believes. Based on the results from the regression analyses, a list of suggested behaviour change techniques was designed using the Behaviour Change Wheel (BCW) framework and the BCT taxonomy (BCTTv1).FindingsThis research suggested that Beliefs about Consequences, Beliefs about Capabilities, Goal Conflict, Coping Planning, and Environmental Context and Resources are the main factors, influencing the positive attitude towards VAS and the self-reported desire to try it in the future. Future interventions were recommended and supported by 22 possible BCTs identified using the BCW approach. The TDF and BCW proved to be useful models for identifying both internal and external factors influencing fitness fans during the adoption of the new sportstech.Originality/valueThe main contribution of the present work was the implementation of a structured and effective approach derived from the healthcare domain to design solutions for behaviour change in the emerging and expanding virtual sports context.
Career paths of multiple jobholders: employers' perspectives and employees' experiences in retail and food service
Authors: Järvensivu Anu , Horppu Ritva , Keränen Hanna 
Published: June 2024

PurposeMultiple jobholding (MJH) is assumed to be a growing phenomenon due to working life changes. This study presents new knowledge on the MJH career paths, from the perspectives of both employers and employees.Design/methodology/approachThe qualitative interview study was focused on retail trade and restaurant and food service industries in Finland, where MJH is a quite common work arrangement compared to other European countries. The data were analyzed with the concepts of the chaos theory of careers and with an abductive thematic content analysis.FindingsAccording to the results, several events and intertwined factors may lead individual careers gradually to MJH. Changing personal and family situations and leisure time needs attracted the careers towards MJH. MJH was not only a financial necessity to employees, but it also served their flexibility interests. The interviewed employers applied flexible non-standard employment arrangements mainly due to rapidly varying labor needs established in the industries. It was important for them to strengthen the non-standard core employees' sense of belonging to the work community. However, employees with work ability challenges were in risk to end up in peripheral positions at the labor market.Originality/valuePrevious research on multiple jobholding has not combined employers’ perspectives of MJH to employees’ experiences of career paths.
A comprehensive analysis of the implications of artificial intelligence adoption on employee social well-being in South African facility management organizations
Authors: Moghayedi Alireza , Michell Kathy , Awuzie Bankole , Adama Unekwu Jonathan 
Published: June 2024

Purpose
The purpose of this study is to explore the increased uptake of Artificial Intelligence (AI) technology by Facility Management (FM) organizations for enhanced operational efficiency and competitive advantage. While AI adoption in FM has been widely reported, limited attempts have been made to assess its impact on the social well-being of FM employees. To contribute towards addressing this gap, this study established the essential employee social well-being factors mostly impacted by the adoption of AI in South African FM organizations.

Design/methodology/approach
A four-stage design comprising a comprehensive review of literature, expert interviews, questionnaire census and focus group discussion sessions was used to elicit data from a sample of participants drawn from 22 South African FM organizations. The data was analyzed using a combination of content analysis, relative importance index and interpretative structural modeling for various data sets toward achieving the study’s objectives.

Findings
Sixteen employee social well-being factors, classified under job satisfaction, social relationship and knowledge development categories, respectively, were identified as being impacted by AI adoption in FM organizations. Furthermore, it was established that job security, job autonomy and professional status, which belong to the job satisfaction social well-being factor category, were deemed by FM employees as being mostly impacted by AI adoption.

Practical implications
The enhanced understanding of the impact of AI adoption on FM employees’ social well-being factors will contribute to the development of a collaborative intelligence framework for managing AI adoption in FM organizations toward engendering optimal AI–FM employee relationships for improved productivity.

Originality/value
Besides being one of the foremost studies to investigate the impact of AI adoption on FM employees’ social well-being, this study introduces a hierarchical framework of understanding employee social well-being factors based on multi-stakeholder perspectives.
Corporate social responsibility: does risk-taking attitude matter?
Authors: Hartmann Caroline , Chen Chu , Hayek Mario 
Published: June 2024

Purpose
The purpose of this paper is to understand the role of risk-taking attitude as an important antecedent to corporate social responsibility (CSR) initiatives.

Design/methodology/approach
The authors use regression models on a sample of 2,136 publicly traded US companies over a 10-year period.

Findings
Corporate risk-taking encourages the pursuit of CSR initiatives and internal (i.e. board strength) and external (i.e. financial analysts) corporate governance mechanisms strengthen that relationship.

Originality/value
While pursuing CSR initiatives involves financial and reputational risks that are evident by the variability in the outcomes (e.g. firm value) of firms that have historically undertaken CSR initiatives, to the best of the authors’ knowledge, this is the first paper to theoretically explain why risk-taking is an important antecedent to CSR and empirically test that relationship.
The joint impact of burnout and neurotic personality on career satisfaction and intention to leave among health workers during the first 2 years of COVID-19
Authors: Osei Hannah Vivian , Arthur Justice , Aseibu Francis , Osei-Kwame Daniel , Fiakeye Rita , Abama Charity 
Published: June 2024

PurposeThe purpose of the study is to examine the psychological impact of COVID-19 on health workers' career satisfaction and intention to leave the health profession, with neurotic personality type as a moderator.Design/methodology/approachA total of 277 health workers in two public hospitals in Ghana were included in this study. Purposive and convenience sampling techniques were adopted for the study, focusing on eight departments that were involved in the management of COVID-19 cases. Validated instruments were used to measure burnout, intention to leave, neurotic personality and career satisfaction. Using AMOS and partial least squares structural equation modeling (PLS-SEM), various techniques were employed to analyze mediating and moderating mechanisms.FindingsThe departments had staff sizes ranging from 19 to 40, with 67% female and 33% male, with an average age of 31. Nurses accounted for the majority of responses (67.8%), followed by physicians (13.9%), sonographers (0.9%), lab technicians (0.9%) and other respondents (16.5%). The study found that health workers’ level of burnout during COVID-19 had a positive effect on their intention to leave the health profession. Career satisfaction does not mediate this relationship; however, career satisfaction negatively influences the intention to leave the health profession. A neurotic personality does not moderate this relationship.Originality/valueThis study provides validation of burnout and intention to leave among health workers in Ghana during COVID-19 and supports the proposition that threats to resources (burnout) and having a resource (career satisfaction) have effects on the intention to leave one’s profession.