bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rearrangement ofMYCIs Associated With Poor Prognosis in Patients With Diffuse Large B-Cell Lymphoma Treated in the Era of Rituximab
Authors: Barrans Sharon , Crouch Simon , Smith Alex , Turner Kathryn , Owen Roger , Patmore Russell , Roman Eve , Jack Andrew 
Published: May 2010

PurposeRearrangement of MYC occurs in a proportion of diffuse large B-cell lymphomas (DLBCL), where they may be associated with an adverse clinical outcome. The aim of this study was to determine the frequency of MYC translocations in DLBCL and their prognostic impact in the era of cyclophosphamide, doxorubicin, vincristine, and prednisone plus rituximab (CHOP-R) therapy.Patients and MethodsThree hundred three patients with previously untreated DLBCL, with no evidence of underlying follicular lymphoma, were investigated using immunohistochemistry and interphase fluorescent in situ hybridization for MYC, BCL6, and t(14;18)/BCL2 rearrangements. All patients (median age, 71.1 years; range, 23 to 96 years) were treated when CHOP-R was standard therapy for DLBCL and observed for a maximum of 4 years. Overall survival (OS) at 3 years was 49% (95% CI, 42% to 56%).ResultsMYC rearrangements were demonstrated in 35 (14%) of 245 biopsies with data available. Of these, 26 (74%) also had a t(14;18), 10 (26%) were BCL6 and MYC rearranged, and seven had all three abnormalities. Only age, International Prognostic Index, and MYC rearrangement retained prognostic significance in the final model. OS was significantly worse for patients with rearrangement of MYC (survival probability at 2 years = 0.35 in v 0.61 in the nonrearranged group).ConclusionThe presence of a MYC rearrangement is a strongly adverse prognostic factor in CHOP-R–treated patients and can be used in combination with patients' age and IPI to accurately predict clinical outcome. In DLBCL, rearrangement of MYC is rarely found as the sole genetic abnormality and the poor prognosis of these patients is likely to reflect a synergistic effect alongside deregulation of BCL6 or BCL2.
Nurse-led varicose vein assessment and implementation of guidelines for treatment
Authors: Holdsworth J , Robinson L , Williamson E A 
Published: May 2010

Objective: Report of a nurse-led clinic to assess varicose veins and, based on locally developed guidelines, only offer treatment to those with skin changes and ulcers in order to reduce the number of patients listed for surgery. Methods: Over 12 months, 152 patients were seen and 145 diagnosed as having varicose veins. Results: Surgery was considered necessary for 38% of those with varicose veins. The remaining 62% were not listed for treatment. When compared with the previous 12 months, 53% fewer patients were listed for surgery and the number on the waiting list had fallen by 62%. Conclusions: This new service was considered to have achieved its aim of reducing the size of the waiting list.
Sub-Surface Initiated Rolling Contact Fatigue—Influence of Non-Metallic Inclusions, Processing History, and Operating Conditions
Authors: Lund Thore B. 
Published: May 2010

Abstract
A number of competing failure mechanisms are involved in bearing failure initiation. For well manufactured bearings operating under clean and well controlled running conditions, sub-surface initiated fatigue is the classical initiation form. Three mechanisms dominate the concept of sub-surface induced initiation and growth: (i) The well documented slow structural breakdown of the steel matrix due to accumulation of fatigue damage in a process superficially similar to tempering, (ii) stress induced generation of butterflies by a process enabling the growth of butterfly micro-cracks and accompanying wings at non-metallic inclusions, and (iii) surface induced hydrogen intrusion causing hydrogen-enhanced fatigue damage accumulation in the matrix. The development of butterflies as a function of contact stress, over-rolling, and non-metallic inclusion characteristics is presented, and the influence of metallurgical cleanliness and processing history on this progression is discussed. The results of laboratory conducted tests are compared to results from field applications where premature spallings have occurred. The progression from butterfly micro-cracks to extending cracks with non-etching borders has been studied. Special interest has been paid to the interaction between the non-metallic inclusion composition and morphology and their propensity to generate butterfly wing formations, as this may affect the way that inclusion harmfulness should be judged in rolling bearing steel quality assurance efforts. Complex oxy-sulfides are the main butterfly initiators in today’s bearing steels.
Untersuchungen an einem Antennenmessplatz im GHz-Bereich
Authors: Kraft Karl Heinz 
Published: May 2010

Zusammenfassung
Für einen Freifeldmessplatz mit Groundplane für Antennen- und EMV-Messungen insbesondere im GHz. B.reich werden einerseits Berechnungen in Bezug auf ideale Bedingungen durchgeführt und andererseits vor allem Messergebnisse im Frequenz- und Zeitbereich vorgestellt und analysiert. Daraus ergeben sich die Messplatzeigenschaften sowie praktisch relevante Antennenparameter.
Zügige Vermessungsmethode für pneumatische Miniaturkomponenten
Authors: Fritz Stephan , Murrenhoff Hubertus , Siebertz Karl 
Published: May 2010

Zusammenfassung
Der Beitrag stellt eine Methodik vor, mit der die Durchflusseigenschaften pneumatischer Komponenten zeitsparend bestimmt werden können. Durch die auf thermodynamischen Zusammenhängen beruhende Auswertung des statischen Drucks und die explizite Berechnung der Temperatur im Messvolumen kann der instationär umgesetzte Massenstrom bestimmt werden. Die Verifikation der Methodik wird mit Ergebnissen der direkten Massenstrommessung durchgeführt. Die entwickelte Methodik vermeidet Nachteile anderer Verfahren und kann zur 100%-Qualitätskontrolle pneumatischer Komponenten eingesetzt werden.
Werkstückeinfluss bei der Auswertung in der Koordinatenmesstechnik
Authors: Lanza Gisela , Peters Jochen 
Published: May 2010

ZusammenfassungMessergebnisse in der Koordinatenmesstechnik werden in der Regel mit Hilfe idealgeometrischer Ersatzelemente ausgewertet und zu Messergebnissen verknüpft. Formabweichungen des Messobjekts verringern dabei die Aussagekraft der Ausgleichsgeometrie und führen zu einem nicht einheitlichen Einfluss der einzelnen Messpunkte. In dem vorliegenden Artikel wird eine Methode zur Identifikation einflussreicher Messpunkte und zur Bewertung der Unsicherheit der Auswertung durch beobachtete Formabweichungen auf Basis des statischen Resampling-Verfahrens “The Jackknife” beschrieben.
NIR-Feuchtemesstechnik mit vereinfachter Kalibrierfunktion
Authors: Kappes Regina , Grimm Christian 
Published: May 2010

Zusammenfassung
Die Feuchte bestimmt viele Materialeigenschaften wie z. B. die Haltbarkeit und Verarbeitbarkeit. Direkte Feuchtemessmethoden sind zeitraubend und probenzerstörend, weshalb indirekte Messmethoden wie die NIR-Spektroskopie insbesondere für die Prozesskontrolle interessant sind. Die NIR-Spektroskopie bedarf allerdings einer Kalibrierung mit statistischen Methoden. Es wurde daher ein Messgerät entwickelt, bei dem die Kalibrierung durch geschickte Kombination der indirekten Methode der NIR-Spektroskopie mit der direkten Methode der NIR-Trocknung und eine automatische Auswerteroutine deutlich vereinfacht wird. Die Auswerteroutine erstellt aus den eingemessenen Daten zuverlässig ein robustes Modell und validiert es, sodass zur Bedienung keine speziellen Fachkenntnisse notwendig sind. Damit ermöglicht das Gerät einen sehr einfachen Off- und At-line-Einsatz.
Parental Postoperative Pain Management: Attitudes, Assessment, and Management
Authors: Rony Rachel Yaffa Zisk , Fortier Michelle A. , Chorney Jill MacLaren , Perret Danielle , Kain Zeev N. 
Published: May 2010

OBJECTIVES:
Previous studies suggested that parents frequently do not adequately treat postoperative pain that is experienced at home. Reasons for these parental practices have not been extensively studied. Aims of this study were to examine parental postoperative pain assessment and management practices at home as well potential attitudinal barriers to such pain practices.

METHODS:
This was a longitudinal study involving 132 parents of children who were aged 2 to 12 years and undergoing elective outpatient surgery. Parental attitudes about pain assessment and management were assessed preoperatively, and children's pain severity and analgesic administration were assessed postoperatively for the first 48 hours after discharge.

RESULTS:
Although postoperative parental ratings indicated significant pain, parents provided a median of only 1 dose of analgesics (range: 0–3) during the first 48 hours after surgery. In the attitudinal survey, parents' responses have indicated significant barriers. For example, 52% of parents indicated that analgesics are addictive, and 73% reported worries concerning adverse effects. Also, 37% of parents thought that “the less often children receive analgesics, the better they work.” Regression analysis demonstrated that, overall, more preoperative attitudinal barriers to pain management were significantly associated with provision of fewer doses of analgesics by parents (P &lt; .05).

CONCLUSIONS:
Parents detected pain in their children yet provided few doses of analgesics. Parents may benefit from interventions that provide them with information that addresses individual barriers regarding assessing and treating pain.
Prevention of Drowning
Authors:   Committee on Injury, Violence, and Poison Prevention, Weiss Jeffrey 
Published: May 2010

This Technical Report was revised. See https://doi.org/10.1542/peds.2021-052227.
Drowning is a leading cause of injury-related death in children. In 2006, approximately 1100 US children younger than 20 years died from drowning. A number of strategies are available to prevent these tragedies. As educators and advocates, pediatricians can play an important role in the prevention of drowning.
Ten Years Recording Common Oral Clefts with a New Descriptive System
Authors: Luijsterburg Antonius J.M. , Vermeij-Keers Christi 
Published: May 2010

Objective After introducing a new descriptive recording system for congenital craniofacial abnormalities in The Netherlands, common oral clefts are highlighted. Design Prospective observational study. Setting Fifteen cleft palate teams, united in the Dutch Association for Cleft Palate and Craniofacial Anomalies, registered patients from 1997 to 2006. Patients All unoperated patients with a common oral cleft were included. Main Outcome Measures Detailed information and birth prevalence rates of cleft lip/alveolus, cleft lip/alveolus and palate, and cleft palate were provided, relating referral age, gender, family history, additional congenital abnormalities, and syndrome diagnoses to these three categories. Results This study included 3512 patients, resulting in an overall prevalence of 16.6 per 10,000 live births. Patients showed a cleft lip/alveolus (28%), a cleft lip/alveolus and palate (39%), or a cleft palate (33%). The three categories exhibited very heterogeneous cleft types. Mean referral age was 5.8 months (median 3 weeks). Birth weight was the lowest in cleft palate patients (3238 g; p < .001 to .009). Cleft palate patients showed less positive family history concerning congenital anomalies (23%, p < .001 to .013), but more syndrome diagnoses were established in this category (24%, p < .001). Ten percent of all cleft patients showed additional abnormalities of the head and neck area, and 13% displayed congenital anomalies of other systems. Conclusions This new recording method allows adequate description of common oral clefts. Many cleft types exist within these three categories and should be differentiated, because they originate from different time frames and/or cell biological mechanisms during embryogenesis.
Molecular Basis of Williams-Beuren Syndrome: TFII-I Regulated Targets Involved in Craniofacial Development
Authors: Makeyev Aleksandr V. , Bayarsaihan Dashzeveg 
Published: May 2010

Objective The aim of this study is to identify gene targets of TFII-I transcription factors involved in craniofacial development. Design Recent findings in individuals with Williams-Beuren syndrome who show facial dysmorphism and cognitive defects have pointed to TFII-I genes ( GTF2I and GTF2IRD1) as the prime candidates responsible for these clinical features. However, TFII-I proteins are multifunctional transcriptional factors regulating a number of genes during development, and how their haploinsufficiency leads to the Williams-Beuren syndrome phenotype is currently unknown. Results Here we report the identification of three genes with a well-established relevance to craniofacial development as direct TFII-I targets. These genes, craniofacial development protein 1 ( Cfdp1), Sec23 homolog A ( Sec23a), and nuclear receptor binding SET domain protein 1 ( Nsd1), contain consensus TFII-I binding sites in their proximal promoters; the chromatin immunoprecipitation analysis showed that TFII-I transcription factors are recruited to these sites in vivo. Conclusions The results suggest that transcriptional regulation of these genes by TFII-I proteins could provide a possible genotype-phenotype link in Williams-Beuren syndrome.
A New Yardstick for Rating Dental Arch Relationship in Patients with Complete Bilateral Cleft Lip and Palate
Authors: Ozawa Terumi Okada , Shaw William C. , Katsaros Christos , Kuijpers-Jagtman Anne Marie , Hagberg Catharina , Ronning Elisabeth , Semb Gunvor 
Published: May 2010

Objective To develop yardsticks for assessment of dental arch relationship in young individuals with repaired complete bilateral cleft lip and palate appropriate to different stages of dental development. Participants Eleven cleft team orthodontists from five countries worked on the projects for 4 days. A total of 776 sets of standardized plaster models from 411 patients with operated complete bilateral cleft lip and palate were available for the exercise. Statistics The interexaminer reliability was calculated using weighted kappa statistics. Results The interrater weighted kappa scores were between .74 and .92, which is in the “good” to “very good” categories. Conclusions Three bilateral cleft lip and palate yardsticks for different developmental stages of the dentition were made: one for the deciduous dentition (6-year-olds’ yardstick), one for early mixed dentition (9-year-olds’ yardstick), and one for early permanent dentition (12-year-olds’ yardstick).
Treatment of Plagiocephaly with Helmet Molding Therapy: Do Actual Results Mimic Perception?
Authors: Katzel Evan B. , Koltz Peter F. , Sbitany Hani , Girotto John A. 
Published: May 2010

Purpose Actual and perceived improvements from helmet molding therapy for deformational plagiocephaly are demonstrated here. Effective communication of these data by craniofacial teams can help avoid unrealistic expectations and inform parents of expected outcomes. Methods Parents of 61 patients with plagiocephaly were asked to rate their children's head shape and ear position before and after helmet therapy (a score of 1 being abnormal and 10 being normal). Topographic laser head scans for an aged-matched cohort of 91 patients with deformational plagiocephaly were acquired. Cephalic ratio, overall symmetry ratio, radial symmetry index, ear offset, and left and right oblique were recorded before and after molding. The cranial vault asymmetry index (CVSI) score was calculated. Results Parent ratings before and after molding, respectively, were head shape 2.99 ± 1.50 (mean ± SD) versus 7.88 ± 1.64 (p < .0001) and ear position 3.75 ± 2.5 versus 7.73 ± 2.34 (p < 0.0001). Measurements before and after molding were cephalic ratio 0.89 ± 0.07 versus 0.87 ± 0.08 (p < .0001), overall symmetry index 0.87 ± 0.05 versus 0.90 ± 0.04 (p < .0001), radial symmetry index 59.9 ± 26.9 mm versus 46.3 ± 25.1 mm (p < .0001), CVSI 7.2 ± 3.75 versus 4.8 ± 2.8 (p < .0001), and ear offset 5.7 versus 5.5 mm (p = .58). Conclusions Helmet molding produces reproducible changes in head shape. Despite relatively small actual changes on topographic laser imaging, parents perceive a large correction in head shape and ear position following helmet molding. Craniofacial teams can use these data and head scans before helmet molding to provide parents with realistic expectations for the outcome of their child's helmet molding therapy.
Nematodes of Cithariniella (Pharyngodonidae) from freshwater fishes in Senegal, with a key to species
Authors: Koubková B. , Baruš V. , Hodová I. 
Published: May 2010

Abstract
Three nematode species of Cithariniella (Pharyngodonidae), C. citharini, C. khalili, and C. gonzalesi, were recorded from the recta of squeaker (Mochokidae: Siluriformes) and citharinid (Citharinidae: Characiformes) fishes from Senegal, West Africa. Morphological characteristics obtained by scanning electron microscopy (form of oral aperture and cephalic papillae, presence of lateral alae, distribution and form of cloacal papillae, simple or paired papillae on tail of males, eggs with numerous long filaments on each pole in females) correspond well to the generic diagnosis and represent species differences. The shape and size of the cephalic papillae and lips were identified as a new determination feature. C. gonzalesi is reported for the first time from Senegal and its host, Paradistichodus dimidiatus, represents a new host record. A tentative simple key for differentiating C. citharini, C. khalili, C. gonzalesi and C. petterae is provided based upon these results.
Speed of Visual Sensorimotor Processes and Conductivity of Visual Pathway in Volleyball Players
Authors: Zwierko Teresa , Osinski Wieslaw , Lubinski Wojciech , Czepita Damian , Florkiewicz Beata 
Published: May 2010

Speed of Visual Sensorimotor Processes and Conductivity of Visual Pathway in Volleyball Players
Volleyball is a dynamic game which requires a high level of visual skills. The first aim of this study was to investigate the several aspects of reaction times (RT) to visual stimuli in volleyball players (12) compared to non-athletic subjects (12). By using the tests included in the Vienna Test System (Schuhfried, Austria), simple reaction time (SRT), choice reaction time (CRT) and peripheral reaction time (PRT) were examined. The second aim of this study was to assess the neurophysiological basis of early visual sensory processing in both examined groups. We measured two sets of pattern-reversal visual evoked potentials (VEPs) during monocular central field stimulation (Reti Scan, Roland Consult, Germany). The latencies of waves N75, P100 and N135 were determined. We observed significantly shorter (p<0.05) total reaction time to stimuli appearing in the central and peripheral field of vision in the volleyball players compared to non-athletes. With regard to SRT and CRT the main differences between the groups appeared in pre-motor reaction times. Volleyball players had shorter VEPs P100 wave latencies (p<0.05) than the non-athlete group. The results indicate faster signal transmission in visual pathways in athletes than in non-athletes. This fact can be attributed to the effect of rapid visual-activity-demanding sports on the central nervous system.
Relationship between Jump Test Results and Acceleration Phase of Sprint Performance in National and Regional 100m Sprinters
Authors: Habibi Abdolhamid , Shabani Mehrzad , Rahimi Esmaeil , Fatemi Rouhollah , Najafi Abdolrahman , Analoei Hossein , Hosseini Morad 
Published: May 2010

Relationship between Jump Test Results and Acceleration Phase of Sprint Performance in National and Regional 100m Sprinters
The purpose of this research was to identify the relationship between jump test results and acceleration phase of sprint performance in national and regional 100m sprinters. Fifteen male (age 21.89 ± 3.26 years; body height 1.72.66 ± 3.20 m; body mass 61.35 ± 11.40 kg; 100 m personal best: 11.67 + 0.46 s {11.00 - 12.19}) track sprinters at a national and regional competitive level performed 10 m sprints from a block start. Anthropometric dimensions, along with squat jump (SJ), countermovement jump (CMJ), continuous straight legged jump (SLJ), single leg hop for distance, and single leg triple hop for distance measures of power were also tested. Pearson correlation analysis revealed the single leg hop for distance with front and back leg (respectively, r = -0.74 and r = -0.76; p = 0.021 and p = 0.017), and the single leg triple hop for distance with front and/or back leg (respectively, r = -0.84 and r = -0.89; p = 0.004 and p = 0.001), generated capabilities to be strongly related to sprint performance. Further linear regression analysis predicted an increase in the single leg hop for distance with front and back leg of 10 cm, to both resulted in a decrease of 0.07 s in 10 m sprint performance. Further, an increase in the single leg triple hop for distance with front and/or back leg of 10 cm was predicted to result in a 0.08 s reduction in 10 m sprint time. The results of this study seem to suggest that the ability to gain more distance with the single leg hop and the single leg triple hop for distance to be good indicators for predicting sprint performance over 10 m from a block start.
The Factor Structure of Chosen Kinematic Characteristics of Take-Off in Ski Jumping
Authors: Vodicar Janez , Jost Bojan 
Published: May 2010

The Factor Structure of Chosen Kinematic Characteristics of Take-Off in Ski Jumping
With a sample of 29 of the best Slovenian ski jumpers, a research project was carried out with the purpose of determining the structure relation of chosen dynamic and kinematic variables during the take-off of ski jumpers. The experiment was performed in August 2008 on the jumping hill in Hinterzarten, Germany (K=95m). The subjects jumped seven times without breaks between rounds. The analysis was done on variables that determine the technique of take-off in ski jumping (in-run velocity - km/h, vertical take-off velocity - m/s, precision of take-off - cm). The criteria variable was the length of the jump (m). The variability of the long distance of the jumps was significantly strong. The reliability of all used multi-item variables was high and satisfactory in most variables (in-run velocity - 0.98, vertical take-off velocity - 0.98, precision of take-off - 0.85, length of the jump - 0.95). The factor analysis produced an independent latent structure (explanation of variance = 93.3%) of five specific factors (1. in-run velocity connected to distance jumped (39.8 % of VAR.), 2. vertical take-off velocity strongly connected to distance jumped (26.0 % of VAR.), 3. precision of take-off partly connected to distance jumped (14.9 % of VAR.), 4. precision of take-off in the 7th round (6.7 % of VAR.), 5. precision at take-off in the 4th round (5.7 % of VAR.). The present factor structure confirms the hypothetical model of three independent motor tasks to be optimally realized in the take-off of the ski jumper. Criteria variables influencing the length of jumps were mainly associated with the first two factors, which confirm the basic hypothesis that the length of the jump reflects the overall output quality of the first two factors. The accurancy factor of take-off affects the length of the jumps indirectly and latently through these two fundamental factors.