bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insight–HXMT observations of thermonuclear X-ray bursts from 4U 1608–52 in the low/hard state: the energy-dependent hard X-ray deficit and cooling saturation of the corona
Authors: Chen Y P , Zhang S , Ji L , Zhang S N , Peng J Q , Kong L D , Chang Z , Shui Q C , Tao L , Qu J L , Ge M Y , Li J 
Published: May 2024

ABSTRACT
During thermonuclear bursts, it is suspected that cooling of the corona by the burst emission may be the cause of hard X-ray deficits. Although such a deficit has been observed in nine sources, it has not been observed from 4U 1608–52, a nearby prolific burster. Therefore, the authenticity and universality of the hard X-ray deficit may be in question. To investigate this suspicion, Insight–HXMT performed cadence observations during the low/hard state of 4U 1608–52 in 2022 September and detected 10 thermonuclear X-ray bursts. Two of these bursts show a double-peaked structure in the soft X-ray band, which could be caused by the high temperature of the burst emission and a marginal photospheric radius expansion (PRE) around the burst peak time. This is indicated by their peak fluxes being up to the Eddington limit and having a large colour factor at the peak of the bursts. A hard X-ray deficit is observed at a significant level during bursts at &gt; 30 keV. Furthermore, the fraction of this deficit shows saturation at 50 per cent for the first eight bursts. This saturation may indicate that the corona is layered and only part of the corona is cooled by the bursts: for example, the part close to the neutron star surface is cooled while the rest remains intact during bursts. This result provides a clue to the geometry of the corona. For example, a possible scenario is that the corona has two forms: a quasi-spheric corona between the neutron star and the disc and a disc corona on both surfaces of the disc.
Analysis of galaxies at the extremes: a kinematic analysis of the Virgo cluster dwarfs VCC 9 and VCC 1448 using the Keck cosmic web imager
Authors: Gannon Jonah S , Forbes Duncan A , Romanowsky Aaron J , Brodie Jean P , Haacke Lydia , Ferré-Mateu Anna , Danieli Shany , van Dokkum Pieter , Buzzo Maria Luisa , Couch Warrick J , Shen Zili 
Published: May 2024

ABSTRACT
We present spatially resolved Keck Cosmic Web Imager stellar spectroscopy of the Virgo cluster dwarf galaxies VCC 9 and VCC 1448. These galaxies have similar stellar masses and large half-light radii but very different globular cluster (GC) system richness (∼25 versus ∼99 GCs). Using the KCWI data, we spectroscopically confirm 10 GCs associated with VCC 1448 and one GC associated with VCC 9. We make two measurements of dynamical mass for VCC 1448 based on the stellar and GC velocities, respectively. VCC 1448’s mass measurements suggest that it resides in a halo in better agreement with the expectation of the stellar mass–halo mass relationship than the expectation from its large GC counts. For VCC 9, the dynamical mass we measure agrees with the expected halo mass from both relationships. We compare VCC 1448 and VCC 9 to the GC-rich galaxy Dragonfly 44 (∼74 GCs), which is similar in size but has ∼1 dex less stellar mass than either Virgo galaxy. In dynamical mass – GC number space, Dragonfly 44 and VCC 1448 exhibit richer GC systems given their dynamical mass than that of VCC 9 and other ‘normal’ galaxies. We also place the galaxies in kinematics–ellipticity space finding evidence of an anticorrelation between rotational support and the fraction of a galaxy’s stellar mass in its GC system, that is, VCC 9 is more rotationally supported than VCC 1448, which is more rotationally supported than Dragonfly 44. This trend may be expected if a galaxy’s GC content depends on its natal gas properties at formation.
Dynamical coupling of Keplerian orbits in a hierarchical four-body system: from the Galactic Centre to compact planetary systems
Authors: Singhal M , Šubr L , Haas J 
Published: May 2024

ABSTRACT
This study focuses on the long-term evolution of two bodies in nearby initially coplanar orbits around a central dominant body perturbed by a fourth body on a distant Keplerian orbit. Our previous works that considered this setup enforced circular orbits by adding a spherical potential of extended mass, which dampens Kozai–Lidov oscillations; it led to two qualitatively different modes of the evolution of the nearby orbits. In one scenario, their mutual interaction exceeds the effect of differential precession caused by a perturbing body. This results in a long-term coherent evolution, with nearly coplanar orbits experiencing only small oscillations of inclination. We extend the previous work by (i) considering post-Newtonian corrections to the gravity of the central body, either instead of or in addition to the potential of extended mass, (ii) relaxing the requirement of strictly circular orbits, and (iii) removing the strict requirement of complete Kozai–Lidov damping. Thus, we identify the modes of interorbital interaction described for the zero eccentricity case in the more general situation, which allows for its applicability to a much broader range of astrophysical systems than considered initially. In this work, we scale the systems to the orbits of S-stars; we consider the clockwise disc to represent the perturbing body, with post-Newtonian corrections to the gravity of Sagittarius A* playing the role of damping potential. Considering post-Newtonian corrections, even stellar-mass central bodies in compact planetary systems can allow for the coupled evolution of Keplerian orbits.
A stochastic gravitational wave background in LISA from unresolved white dwarf binaries in the Large Magellanic Cloud
Authors: Rieck Steven , Criswell Alexander W , Korol Valeriya , Keim Michael A , Bloom Malachy , Mandic Vuk 
Published: May 2024

ABSTRACT
The Laser Interferometer Space Antenna (LISA) is expected to detect a wide variety of gravitational wave sources in the mHz band. Some of these signals will elude individual detection, instead contributing as confusion noise to one of several stochastic gravitational-wave backgrounds (SGWBs) – notably including the ‘Galactic foreground’, a loud signal resulting from the superposition of millions of unresolved double white dwarf binaries (DWDs) in the Milky Way. It is possible that similar, weaker SGWBs will be detectable from other DWD populations in the local Universe, including the Large Magellanic Cloud (LMC). We use the Bayesian LISA Inference Package (blip) to investigate the possibility of an anisotropic SGWB generated by unresolved DWDs in the LMC. To do so, we compute the LMC SGWB from a realistic DWD population generated via binary population synthesis, simulate 4 years of time-domain data with blip comprised of stochastic contributions from the LMC SGWB and the LISA detector noise, and analyse this data with blip’s spherical harmonic anisotropic SGWB search. We also consider the case of spectral separation from the Galactic foreground. We present the results of these analyses and show, for the first time, that the unresolved DWDs in the LMC will comprise a significant SGWB for LISA.
Correcting for the overabundance of low-mass quiescent galaxies in semi-analytic models
Authors: Harrold Jimi E , Almaini Omar , Pearce Frazer R , Yates Robert M 
Published: May 2024

ABSTRACT
We compare the l-galaxies semi-analytic model to deep observational data from the UKIDSS Ultra Deep Survey (UDS) across the redshift range 0.5 &lt; z &lt; 3. We find that the overabundance of low-mass, passive galaxies at high redshifts in the model can be attributed solely to the properties of ‘orphan’ galaxies, i.e. satellite galaxies where the simulation has lost track of the host dark matter sub-halo. We implement a simple model that boosts the star formation rates in orphan galaxies by matching them to non-orphaned satellite galaxies at a similar evolutionary stage. This straightforward change largely addresses the discrepancy in the low-mass passive fraction across all redshifts. We find that the orphan problem is somewhat alleviated by higher resolution simulations, but the preservation of a larger gas reservoir in orphans is still required to produce a better fit to the observed space density of low-mass passive galaxies. Our findings are also robust to the precise definition of the passive galaxy population. In general, considering the vastly different prescriptions used for orphans in semi-analytic models, we recommend that they are analysed separately from the resolved satellite galaxy population, particularly with JWST observations reigniting interest in the low-mass regime in which they dominate.
The value of virtual molecular tumor boards for informed clinical decision-making
Authors: Angel Martín , Demiray Mutlu , Dişel Umut , Passos João 
Published: May 2024

Abstract
Genomic profiling and other new technologies have increased the volume and complexity of information available for guiding clinical decision-making in precision oncology. Consequently, there is a need for multidisciplinary expert teams, in the form of molecular tumor boards (MTBs), who can translate this information into a therapeutic plan, including matching patients to suitable clinical trials. Virtual MTBs (vMTBs) can help to overcome many of the challenges associated with in-person MTBs, such as limited time availability, access to appropriate experts or datasets, or interactions between institutions. However, real-world experience from vMTBs is lacking. Here, we describe oncologists’ vMTB experiences and the value of working with multicenter and/or multinational vMTBs. We also address knowledge gaps and barriers that could affect the implementation of vMTBs in routine clinical practice. Case studies from Argentina, Turkey, and Portugal illustrate the value of informed clinical decision-making by vMTBs, including expansion of therapeutic options for patients, faster time to treatment, and the resulting improvement in patient outcomes or impact of vMTB discussions on patients. With the uptake of comprehensive genomic profiling and the evolution of some cancers now being conceptualized as a collection of rare diseases with small patient populations based on molecular profiling, the importance of MTBs has increased in modern cancer management. However, an adjustment in clinical decision-making by healthcare professionals is required and evidence of the added value of vMTBs is lacking. Existing vMTBs and recommendations from participating oncologists could point toward a structured evaluation and analysis of this new platform.
Molecularly matched targeted therapy: a promising approach for refractory metastatic melanoma
Authors: Connell Emily , Gerard Émilie , Oules Bénédicte , Brunet-Possenti Florence , Lamoureux Anouck , Bonnefille Hugo , Mary-Prey Sorilla , Carrasquilla Ana , Mouret Stéphane , Kramkimel Nora , Lesage Candice , Stoebner Pierre-Emmanuel , Bartoli Axel , Monestier Sandrine , Correard Florian , Gros Audrey , Jeanson Arnaud , Ouafik L’Houcine , Gaudy-Marqueste Caroline , Tomasini Pascale , Charles Julie , Amini-Adle Mona , Malissen Nausicaa 
Published: May 2024

Abstract

Background
Only a fraction of patients with metastatic melanoma derive durable benefit from approved treatments. The clinical impact of personalized medicine strategies for melanoma, apart from BRAF, NRAS, or CKIT targeting, has rarely been reported.

Materials and Methods
By means of the Group of Cutaneous Oncology of the French Society of Dermatology, we retrospectively included all patients with advanced melanoma aged 18 years and older for whom molecular testing identified one or more actionable molecular alterations and who accordingly received molecularly matched therapy. We excluded patients with only BRAF, NRAS, or CKIT alterations and patients who received molecularly matched therapy for less than 15 days.

Results
We included 26 patients with a median follow-up of 8 months (1-54), a median age of 63 years (24-89), and a sex ratio of 2.7. These patients had been heavily pretreated, and 64% had elevated LDH levels. The disease control rate was 38%, with 4 cases of partial response (overall response rate: 15%) and 6 of stable disease for at least 6 months. The median duration of treatment was 3.1 months (0.9-13.5). Among patients with disease control, the median duration of control was 6.6 months (2.6-13.5) and 3 cases were ongoing at the end of the study. Patients with controlled disease had GNA11, MAP2K1, FYCO1-RAF1, HRAS, ATM, CCND1, MDM2/CDK4, and CDKN2A/NRAS alterations.

Conclusions
High-throughput sequencing followed by matched targeted therapy is a promising approach for patients with advanced melanoma refractory to approved treatments.
The ASCENT Trial: a phase 2 study of induction and consolidation afatinib and chemoradiation with or without surgery in stage III EGFR-mutant NSCLC
Authors: Chang Allison E B , Piper-Vallillo Andrew J , Mak Raymond H , Lanuti Michael , Muzikansky Alona , Rotow Julia , Jänne Pasi A , Mino-Kenudson Mari , Swanson Scott , Wright Cameron D , Kozono David , Marcoux Paul , Piotrowska Zofia , Sequist Lecia V , Willers Henning 
Published: May 2024

Abstract

Background
The role of tyrosine kinase inhibitors (TKIs) in early-stage and metastatic oncogene-driven non–small cell lung cancer (NSCLC) is established, but it remains unknown how best to integrate TKIs with concurrent chemoradiotherapy (cCRT) in locally advanced disease. The phase 2 ASCENT trial assessed the efficacy and safety of afatinib and cCRT with or without surgery in locally advanced epidermal growth factor receptor (EGFR)-mutant NSCLC.

Patients and Methods
Adults ≥18 years with histologically confirmed stage III (AJCC 7th edition) NSCLC with activating EGFR mutations were enrolled at Mass General and Dana-Farber/Brigham Cancer Centers, Boston, Massachusetts. Patients received induction afatinib 40 mg daily for 2 months, then cisplatin 75 mg/m2 and pemetrexed 500 mg/m2 IV every 3 weeks during RT (definitive or neoadjuvant dosing). Patients with resectable disease underwent surgery. All patients were offered consolidation afatinib for 2 years. The primary endpoint was the objective response rate (ORR) to induction TKI. Secondary endpoints were safety, conversion to operability, progression-free survival (PFS), and overall survival (OS). Analyses were performed on the intention-to-treat population.

Results
Nineteen patients (median age 56 years; 74% female) were enrolled. ORR to induction afatinib was 63%. Seventeen patients received cCRT; 2/9 previously unresectable became resectable. Ten underwent surgery; 6 had a major or complete pathological response. Thirteen received consolidation afatinib. With a median follow-up of 5.0 years, median PFS and OS were 2.6 (95% CI, 1.4-3.1) and 5.8 years (2.9-NR), respectively. Sixteen recurred or died; 6 recurrences were isolated to CNS. The median time to progression after stopping consolidation TKI was 2.9 months (95% CI, 1.1-7.2). Four developed grade 2 pneumonitis. There were no treatment-related deaths.

Conclusion
We explored the efficacy of combining TKI with cCRT in oncogene-driven NSCLC. Induction TKI did not compromise subsequent receipt of multimodality therapy. PFS was promising, but the prevalence of CNS-only recurrences and rapid progression after TKI discontinuation speak to unmet needs in measuring and eradicating micrometastatic disease.
Mandalas and Monarchs
Authors: Chemburkar Swati 
Published: May 2024

Abstract
From 7th to 13th centuries, network of Buddhist monks stretched from the Ganges Valley to Japan and from the Himalayan snows to the Maritime Sea routes. It became responsible for bringing the new esoteric form of Buddhism that was geared towards the representation of royal power than the earlier monastic version. The esoteric Buddhism attracted many kings, as it promised direct engagement with cosmic Buddhas and gods otherwise inaccessible to human conceptual powers. It was based on (1) ritual initiations prescribed in tantras; (2) recitation of magical formulas—mantras; and (3) architectural development of the model of the Buddhist cosmos—mandalas. Mandalas became valuable tools for Buddhist monks for reorganizing the religious/political landscapes. This study finds that the tantric Garbhadhātu and Vajradhātu manddalas along with their modified versions were wide spread than formerly thought and can be traced in the architecture of monuments from the Ganges valley to the island of Java.
To Mix or Not to Mix: Details of Magma Storage, Recharge, and Remobilization during the Pacheco Stage at Misti Volcano, Peru (≤21–2 ka)
Authors: Takach Marie K , Tepley Frank J , Harpel Christopher J , Aguilar Rigoberto , Rivera Marco 
Published: May 2024

Abstract
We investigate ten of the most recent tephra-fall deposits emplaced between ≤21 and 2 ka from the Pacheco stage of Misti volcano, Peru, to elucidate magma dynamics and explosive eruption triggers related to magma storage, recharge, and remobilization. Whole-rock, glass, and mineral textures and compositions indicate the presence of broadly felsic, intermediate, and mafic magmas in a chemically and thermally stratified magma storage system (Zones 1–3) that interact to differing extents prior to eruption. Intermediate magmas are defined by plagioclase + amphibole + two-pyroxenes + Fe-Ti oxides and phase equilibria indicate they formed at ~300 to 600 MPa and ~950°C to 1000°C. Intermediate magmas dominate the Pacheco stage and either erupted alone as hybridized magmas or mingled with minor volumes of cool felsic magmas (~800°C) in which only plagioclase + Fe-Ti oxides are stable. Felsic magmas do not exclusively comprise any tephra-fall deposit emplaced during the Pacheco stage but were remobilized by recharge and mixing with intermediate magmas in order to erupt. Furthermore, felsic-hosted amphibole cognate to the intermediate magmas are reacted despite the felsic magmas being water saturated, which suggests they are staged above the amphibole stability limit (≤200 MPa). The cryptic presence of mafic magmas is indicated by high-An plagioclase cores (An74–88), rare anhedral olivine (Fo77–80), and possibly high Mg# augite and amphibole (up to Mg# 84 and 77, respectively). The dearth of basalt to basaltic andesite melts recorded in erupted glasses and exclusivity of high-An plagioclase to crystal cores signals mafic magmas are staged deeper in the crust than the intermediate magmas. Periodic interactions between these magmas tracked via glass compositions and crystal exchange reveal an alternation between the production of mingled magmas and their eruption shortly after a recharge event, followed by a period of homogenization and eruption of hybridized magmas. As such, we identify magma recharge as a key mechanism by which half of the explosive eruptions were triggered in the Pacheco stage. A &gt;100°C increase in Misti’s fumarole temperatures from 1967 to 2018 coincident with changes in fumarolic gas compositions is consistent with degassing of a mafic recharge magma, signaling that Misti could produce similar explosive eruptions in the future.
The Volcanism of the Meseta del Lago Buenos Aires, Patagonia: the Transition from Subduction to Slab Window
Authors: Guest Imani A , Saal Alberto E , Mallick Soumen , Gorring Matthew L , Kay Suzanne M 
Published: May 2024

Abstract
The Meseta del Lago Buenos Aires (MLBA) in southern Patagonia, a volcanic plateau formed from ~12 Ma to present, provides an opportunity to investigate the temporal evolution in volcanism as this region transitions from the subduction of the Nazca plate to the formation of the slab window produced by the collision of the Chile Ridge and the Andean subduction zone. Here, we report new major, minor, and trace element contents, as well as Sr, Nd, Pb, and Hf isotopes of the MLBA lavas. Three distinct geochemical endmembers can be distinguished in the MLBA basalts: a subduction-influenced endmember, a transitional component similar to the South Atlantic enriched mid-ocean ridge basalts, and an enriched component akin to the EM1 mantle composition. Lavas older than ~1.5 Ma define a compositional continuum between the subduction-influenced and transitional endmembers; this trend is also present in many other southern Patagonian plateaus regardless of their distance to the trench, eruption age, and the composition of the continental blocks where they are located. In contrast, MLBA basalts younger than ~1.5 Ma uniquely define a transition into the EM1 mantle component at the time when this region was affected by the slab window. The estimated pressures and temperatures of mantle-melt equilibration for the MLBA basalts indicates an increase in both parameters after the formation of the slab window that roughly correlate with the changes in lava composition. The basalts’ composition from all southern Patagonia plateaus points to the presence of the South Atlantic mid-ocean ridge basalt mantle influenced by the Discovery, Shona, and Bouvet hotspots rather than the sub-slab mantle, as represented by the Chile Ridge basalts. This observation challenges the hypothesis that the sub-slab mantle within the slab window has had an important role in the composition of the erupted lavas. Instead, it suggests the presence of a South Atlantic mantle beneath southern Patagonia either within the mantle wedge, consistent with a long-lasting South Atlantic convection cell beneath South America, or in the subcontinental lithospheric mantle metasomatized before or just after the opening of the South Atlantic basin, as demonstrated by the composition of southern Patagonia mantle xenoliths. Although it is difficult to precisely distinguish the contributions of the asthenosphere from that of the metasomatized subcontinental lithospheric mantle beneath this region, our work suggests significant contributions from the latter in the composition of the MLBA lavas.
The Application of Australian Rights Protections to the Use of Hepatitis C Notification Data to Engage People ‘Lost to Follow Up’
Authors: Saich Freya , Walker Shelley , Hellard Margaret , Stoové Mark , Seear Kate 
Published: May 2024

Abstract
Hepatitis C is a global public health threat, affecting 56 million people worldwide. The World Health Organization has committed to eliminating hepatitis C by 2030. Although new treatments have revolutionised the treatment and care of people with hepatitis C, treatment uptake has slowed in recent years, drawing attention to the need for innovative approaches to reach elimination targets. One approach involves using existing notifiable disease data to contact people previously diagnosed with hepatitis C. Within these disease surveillance systems, however, competing tensions exist, including protecting individual rights to privacy and autonomy, and broader public health goals. We explore these issues using hepatitis C and Australia’s legislative and regulatory frameworks as a case study. We examine emerging uses of notification data to contact people not yet treated, and describe some of the ethical dilemmas associated with the use and non-use of this data and the protections that exist to preserve individual rights and public health. We reveal weaknesses in rights protections and processes under Australian public health and human rights legislation and argue for consultation with and involvement of affected communities in policy and intervention design before notification data is used to increase hepatitis C treatment coverage.