bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary Supplementation with 22‐S‐Hydroxycholesterol to Rats Reduces Body Weight Gain and the Accumulation of Liver Triacylglycerol
Authors: Kase Eili Tranheim , Nikolić Nataša , Hessvik Nina Pettersen , Fjeldheim Åse‐Karine , Jensen Jørgen , Thoresen G. Hege , Rustan Arild C. 
Published: March 2012

AbstractThis study explores the pharmacokinetics of 22‐S‐hydroxycholesterol (22SHC) in vivo in rats. We also carried out a metabolic study to explore whether the beneficial effects observed of 22SHC on glucose and lipid metabolism in vitro could be seen in vivo in rats. In the pharmacokinetic study, rats were given 50 mg/kg of [3H]22‐S‐hydroxycholesterol before absorption, distribution and excretion were monitored. In the metabolic study, the effect of 22SHC (30 mg/kg/day for 3 weeks) in rats on body weight gain [chow and high‐fat diet (HFD)], serum lipids triacylglycerol (TAG) content and gene expression in liver and skeletal muscle were examined. Results showed that 22SHC was well absorbed after oral administration and distributed to most organs and mainly excreted in feces. Rats receiving 22SHC gained less body weight than their controls regardless whether the animals received chow diet or HFD. Moreover, we observed that animals receiving HFD had elevated levels of serum TAG while this was not observed for animals on HFD supplemented with 22SHC. The amount of TAG in liver was reduced after 22SHC treatment in animals receiving either chow diet or HFD. Gene expression analysis revealed that two genes (carnitine palmitoyltransferase 2 and uncoupling protein 3) involved in fatty acid oxidation and energy dissipation were increased in liver. Ucp3 expression (both protein and mRNA level) was increased in skeletal muscle, but insulin‐stimulated glucose uptake and TAG content were unchanged. In conclusion, 22SHC seems to be an interesting model substance in the search of treatments for disorders involving aberrations in lipid metabolism.
Reduced expression of nuclear factor kB in oral mucosa undergoing preoperative chemoradiotherapy
Authors: Ikebe Tetsuro , Yamasaki Keiko , Takamune Yasuo , Nakayama Hideki , Shinohara Masanori 
Published: March 2012

AbstractRadiotherapy as well as chemotherapy in head and neck cancer induces severe oral mucositis. Even after healing of the mucositis, however, the oral mucosa looking atrophic is known to be susceptible to injury and infection. In order to investigate such vulnerability of mucosa, we immunohistochemically studied the expressions of Ki‐67, proliferating cell nuclear antigen (PCNA), cyclin D1, nuclear factor (NF)‐kB, and keratinocyte growth factor (KGF) receptor in the oral mucosal keratinocytes undergoing preoperative concurrent chemoradiotherapy for oral cancer, compared with those of the oral mucosa without such therapy. As a result, the expressions of Ki‐67, PCNA, and cyclin D1 were decreased in the chemoradiotherapy‐treated oral keratinocytes. Interestingly, NF‐kB expression, which is known to be enhanced in oral mucositis, was reduced after chemoradiotherapy. The chemoradiotherapy had no effect on the expression of KGF receptor in oral keratinocytes. In conclusion, the vulnerability of oral mucosa undergoing chemoradiation may be associated with reduced NF‐kB expression and impaired growth activity.
Blow-up of solutions of a quasilinear parabolic equation
Authors: Suzuki Ryuichi , Umeda Noriaki 
Published: March 2012

We consider non-negative solutions of the Cauchy problem for quasilinear parabolic equations ut = Δum + f(u), where m > 1 and f(ξ) is a positive function in ξ > 0 satisfying f(0) = 0 and a blow-up conditionWe show that if ξm+2/N /(−log ξ)β = O(f(ξ)) as ξ ↓ 0 for some 0 < β < 2/(mN + 2), one of the following holds: (i) all non-trivial solutions blow up in finite time; (ii) every non-trivial solution with an initial datum u0 having compact support exists globally in time and grows up to ∞ as t → ∞: limtt→∞ inf|x|<Ru(x, t) = ∞ for any R > 0. Moreover, we give a condition on f such that (i) holds, and show the existence of f such that (ii) holds.
Quality of Life in Patients Postcolectomy for Pediatric‐onset Ulcerative Colitis
Authors: Dalal Deepal H. , Patton Dana , Wojcicki Janet M. , Clark Ann L. , Garnett Elizabeth A. , Heyman Melvin B. 
Published: March 2012

ABSTRACTBackground:Ulcerative colitis in children can have a negative effect on quality of life (QOL).Methods:We included 16 of 31 patients who underwent colectomy for ulcerative colitis before 20 years of age between 1980 and 2005 at University of California in San Francisco Benioff Children's Hospital. A disease‐specific QOL questionnaire (Inflammatory Bowel Disease Questionnaire‐32), validated for adults, was used to determine QOL and an additional questionnaire addressing bowel function and reproductive health in long‐term follow‐up of these patients.Results:Median age at the time of survey was 20.3 years (17.9–25.3), and time postcolectomy was 6.9 years (4.8–9.0). Mean total score was 159.7 ± 43.3 (58–210). Two patients (12.5%) had scores of ≥200, 12 (75.0%) had 101 to 199, and 2 (12.5%) had ≤100. Patients ages 18 years or younger at the time of survey showed higher QOL, particularly in emotional health (P = 0.020), social function (P = 0.014), and overall QOL (P = 0.009). Social function scored highest of all of the systems (median 7; interquartile range 4–7). Patients with scores ≤100 had repeated episodes of pouchitis (16–30) compared with the other 14 patients (0–3). Children who were diagnosed ages 12 years or younger tended to have higher QOL (p = 0.072). Years postcolectomy did not correlate to QOL. Eleven patients were sexually active. Two males had feelings of impotence and decreased libido, and 6 females experienced dyspareunia. Three women tried unsuccessfully to conceive after colectomy. One woman became pregnant 4 times, each leading to miscarriage.Conclusions:Younger age at time of colectomy, diagnosis, and survey show higher QOL. Highest satisfaction was found in ability to attend school, work, and social engagements. Pouchitis continued to be an issue for a small number of the patients, with 2 patients having recurring episodes that severely affected QOL. Patients reported decreased sexual activity and fertility at the time of survey due to colectomy, especially for females.
A continuous description of discrete data points in informetrics
Authors: Liu Yuxian , Rousseau Ronald 
Published: March 2012

PurposeThe paper aims to propose the use of spline functions for the description and visualization of discrete informetric data.Design/methodology/approachInterpolating cubic splines: are interpolating functions (they pass through the given data points); are cubic, i.e. are polynomials of third degree; have first and second derivatives in the data points, implying that they connect data points in a smooth way; satisfy a best‐approximation property which tends to reduce curvature. These properties are illustrated in the paper using real citation data.FindingsThe paper reveals that calculating splines yields a differentiable function that still captures small but real changes. It offers a middle way between connecting discrete data by line segments and providing an overall best‐fitting curve.Research limitations/implicationsThe major disadvantage of the use of splines is that accurate data are essential.Practical implicationsSpline functions can be used for illustrative as well as modelling purposes.Originality/valueSplines have hardly ever been used or studied in the information sciences.
Ceramic engine considerations for future aerospace propulsion
Authors: Gohardani Amir S. , Gohardani Omid 
Published: March 2012

PurposeThe purpose of this paper is to outline the potential usage of ceramic engines in combination with other technologies as a possible propulsion contender for future aerospace applications.Design/methodology/approachThe possibility of enabling novel propulsion systems in aerospace engineering is examined through a multilateral review study concerning ceramic engines and a proposed design approach. In view of the benefits and challenges of employing ceramic engines as possible candidates for the sustainable solutions of the future, a fundamental design proposal is presented for a conceptual generic unmanned air vehicle (GUAV).FindingsThe findings of this article identify a number of useful scenarios for future ceramic engine applications and considerations.Research limitations/implicationsIt is imperative to emphasize that this conceptual article solely sheds light on a limited number of key ideas associated with ceramic engines and their possible applications. Thus, many new areas may emerge and impact the application of ceramic engines in light of more in‐depth conceptual studies.Practical implicationsImplications of ceramic engine utilization in aeronautical applications may result in enhanced performance characteristics and less operational costs. Further implications could possibly be extended to various naval/automotive applications and new configurations of transportation vehicles.Social implicationsThe paper aims to generate an interest amongst younger individuals and environmental aware enthusiasts to consider ceramic engines for transportation applications to a greater extent than before.Originality/valueThe implementation of this particular conceptual design results in a synergistic ceramic engine combination with a hybrid airship design in novel aeronautical applications.
Corrosion resistance enhancement of Ti–47Al–2Cr by thermal treatment in a controlled atmosphere
Authors: Saebnoori Ehsan , Shahrabi Taghi , Sabour Rouhaghdam Alireza , Jafarian Majid 
Published: March 2012

PurposeThe purpose of this paper is to investigate the effect of thermal treatment at low partial pressure of oxygen on electrochemical corrosion resistance of Ti‐47Al‐2Cr (at %) intermetallic, known as γ‐TiAl alloy.Design/methodology/approachThe surfaces of the samples were modified by thermal treatment at different temperatures in N2 gas flow for an hour. Characterization of the modified surface layers was carried out by microscopic examinations, hardness and roughness tests, and X‐ray diffraction analyses. Potentiodynamic polarization was used to evaluate the corrosion performance of γ‐TiAl in Ringer's solution.FindingsThe results indicated that the alloy treated at 950 °C had the optimum corrosion resistance, which can be attributed to the formation of an oxide layer by the surface thermal treatment and increase of the passive layer thickness.Practical implicationsLow corrosion rate (CR), high pitting potential (Epit), and more noble corrosion potential (Ecorr) make it possible for γ‐TiAl to be considered as a candidate for biomedical applications.Originality/valueThe treatment described in the paper is a novel method for surface modification of this type of alloy and results showed that it was an effective treatment and that the corrosion resistance improved remarkably.
Enhance green purchase intentions
Authors: Chen Yu‐Shan , Chang Ching‐Hsun 
Published: March 2012

PurposeThe purpose of this study is to develop an original framework to explore the influences of green perceived value and green perceived risk on green purchase intentions and to discuss the mediation role of green trust.Design/methodology/approachThis study applies four original concepts – green perceived value, green perceived risk, green trust, and green purchase intentions – to develop an integral model to enhance green purchase intentions. In addition, this research employs an empirical study by means of the questionnaire survey method to verify the hypotheses and to explore its managerial implications. Structural equation modeling (SEM) is applied to verify the research framework.FindingsThe empirical results show that green perceived value would positively affect green trust and green purchase intentions, while green perceived risk would negatively influence both of them. Furthermore, this study demonstrates that the relationships between green purchase intentions and their two antecedents – green perceived value and green perceived risk – are partially mediated by green trust. Hence, investing resources to increase green perceived value and to decrease green perceived risk is helpful to enhance green trust and green purchase intentions.Originality/valueThis study summarizes the literature on green marketing and relationship marketing into a new managerial framework of green purchase intentions. It utilizes four novel constructs – green perceived value, green perceived risk, green trust, and green purchase intentions – to develop an original research framework to enhance green purchase intentions. Although past research has highlighted the relevant issues about purchase intentions, none explores it about green management. Therefore, this paper develops the research framework of green purchase intentions to fill the research gap.
Organizational logic and feminist organizing: stewardesses for women's rights
Authors: Boone Parsons Donna , Sanderson Kathy , Helms Mills Jean , Mills Albert J. 
Published: March 2012

PurposeJoan Acker proposed her gendered theory of organization as a framework to analyze organizations and to understand how gender underlies organizational structure in such a way as to subordinate women. Much of the previous work that has utilized this framework has examined highly (male‐) gendered organizations. This archival case study aims to use Acker's framework to examine a purportedly female‐gendered organization – the 1970s feminist organization, Stewardesses for Women's Rights (SFWR).Design/methodology/approachUsing these archived materials, this paper uses a critical hermeneutic approach across Acker's framework of gendered organization to make sense of the rise and fall of SFWR. The paper discusses lessons learned from this short‐lived organization.FindingsThe paper finds that societal pressure and organizing women's understanding of what is “real” and valued in an organization pushed them to create an organization that was as highly (male) gendered as the organizations from which they were escaping. Many in the organization never saw SFWR as a “real” organization because of the underlying organizational logic that was directing what the organization should be. Even if the organization did, on the surface, look different than other explicitly male‐gendered organizations, the same underlying organizational logic manifested itself in similar organizational structure.Originality/valueThis archival case study uses Acker's framework to examine a purportedly female‐gendered organization – the 1970s feminist organization SFWR and reveals lessons learned.
Service environment, provider mood, and provider‐customer interaction
Authors: Fowler Kendra , Bridges Eileen 
Published: March 2012

PurposeThe purpose of this paper is to improve understanding of the relationships between the service environment, service provider mood, and provider‐customer interaction. Specifically, mood is evaluated as a potential moderator of the relationship between the service environment and provider‐customer interaction.Design/methodology/approachA multi‐method data collection approach was utilized, including observation and provider and customer surveys. Hypotheses are tested using regression, ANOVA, and MANOVA.FindingsFindings indicate that service provider evaluations of the physical environment improve in the presence of an appropriate ambient scent. Behavioral responses are also enhanced: providers are viewed as more courteous and customers more friendly. Perhaps the most interesting observation is that provider mood moderates the relationship between the service environment and customer perceptions of service provider behavior.Research limitations/implicationsThe only environmental characteristic that was manipulated was scent, and access was granted to only one store over the course of three consecutive Saturdays. Consequently, validity is threatened by the potential for impact of factors other than the manipulated characteristic.Practical implicationsImplications for managers include careful consideration of potential changes to the ambient environment; if introduction of an appropriate scent can be undesirable, other changes may also lead to unexpected results. Changes under consideration should be tested before implementation.Originality/valueThis research extends service theory by examining the relationship between providers and customers in an actual retail setting. Important theoretical contributions include: demonstrating that service provider mood moderates the relationship between service environmental characteristics and customer perceptions of provider behavior; and finding that positive changes to the environment can amplify negative outcomes.
Give your people a cause and inspiration will follow
Authors: Jackson Barry 
Published: March 2012

PurposeThis paper seeks to describe how to lead an effective team and inspire, rather than simply motivate, its members.Design/methodology/approachThe paper explores what makes people act selflessly in a tragedy. It reveals that this kind of behavior results from people feeling that they have a cause. It also describes how having a cause at work, and being led by an inspirational leader, can lead to a truly inspired workforce.FindingsThe paper details the effects that devotion to a cause has, not only on individuals, but also on a team. It explains how team members come closer to each other, act regardless of rank, and find that adversity strengthens rather than weakens their bonds.Practical implicationsThe paper reveals that once this kind of spirit is established in a team, team members will be less likely to defect to other employers.Social implicationsThe paper highlights the importance of making a business into a cause. The people the business serves must be a cause. Most important of all, employees must feel that, for their leader, they are a cause.Originality/valueThe paper reveals the differences between inspiration and motivation, being a leader and merely being a boss.
A commentary on: Demonstrating the Effectiveness of Housing Support Services for People with Mental Health Problems: A Review by Nicholas Pleace and Alison Wallace, Centre for Housing Policy, University of York
Authors: Johnson Robin 
Published: March 2012

PurposeThis paper is an extended review and expert commentary on a recently published study by the Centre for Housing Policy (CHP) which discusses the complexities of research in “housing related support” in the UK context, and proposes further work. This review aims to explore the strengths and limitations of the study; and the potential wider relevance outside the UK research context.Design/methodology/approachThe review methodology is traditionally that of expert opinion. The reviewer draws upon previous evaluation studies of mental health and housing, commissioned by the UK Dept of Health, the (Dept of) Communities and Local Government, the National Institute for Mental Health in England, and the Care Services Improvement Partnership, including additional material on the Mental Health Minimum Dataset.FindingsThe CHP report reviewed raises important questions over the complexities of evidencing innovative services. Despite some omissions, it should be helpful to health local commissioners in assessing the value of services; and the further research the report proposes is to be welcomed. The report also provides a useful introduction to “housing related support” for an international research audience, less familiar with the UK social policy and funding context.Originality/valueThe review introduces and recommends the CHP study – which is itself a valuable contribution to future research on housing‐related support – to a wider audience. The review also includes additional material never before published on the potential research value in the context of the Mental Health Minimum Dataset.
Paul's journey
Authors: Ashton Paul 
Published: March 2012

PurposeThe authors of the previous paper “Staff and ex‐service user co‐working: a counselling service's enhanced response to multiple exclusion homelessness” feel that Paul's contribution and achievements can only be fully appreciated with reference to his own story. It is published here, to appear alongside the account of their joint experience of co‐working, as part of the series on personal perspectives on development work. It aims to give an account of one person's journey into homelessness and mental health problems in the context of multiple exclusion and homelessness.Design/methodology/approachThis paper is a biographical account, with personal reflections.FindingsThere are no findings as such; this is an account of personal experience. It speaks for itself.Originality/valueFully personal accounts are rare, in research journals. Yet personal experience is the bedrock of research, and of outcomes. This account is published here, as a necessary balance to more formal, objective and statistical measures.
Benchmarking the location of health centers at Jeddah city: a GIS approach
Authors: Murad Abdulkader Ali 
Published: March 2012

PurposeThe purpose of this paper is to discuss a GIS application created for health care planning at Jeddah city, Saudi Arabia. The application covers important health care facilities planning issues including defining accessibility to health care facilities, identifying and classifying the distribution of health demand at Jeddah city and modeling spatial variation of patient locations.Design/methodology/approachIn order to build this application, a geo‐database is created that covers points, lines and polygon features such as health care facility location, road network and population districts. In addition, raster surface models are produced using Kriging function which produces raster surfaces for predicting health demand values at the study area.FindingsThe outputs of this application can be used to help health care planners in evaluating the existing location of health care facilities and see if these locations are concentrated at certain city districts. In addition, local health planners can use the created models when deciding where to allocate a new health care facility at Jeddah city.Originality/valueThis application is considered as a spatial decision support system for health planners in Jeddah city. It can be used to define and evaluate location of health centers as well as to identify the spatial accessibility to health centers.
Third time lucky? An exploration of Hutchison Whampoa's involvement in the mobile telecommunications industry
Authors: Whalley Jason , Curwen Peter 
Published: March 2012

PurposeThe purpose of this paper to analyse Hutchison Whampoa's involvement in the telecommunication industry.Design/methodology/approachA brief overview of Hutchison Whampoa is provided before a timeline of the company's involvement in the telecommunications industry is presented. This is followed by the recounting of the company's performance in three areas, namely geographical footprint, mobile subscribers and financial returns. After discussing these three areas, an assessment of the company's exposure to 3G markets is made.FindingsOne finding is that Hutchison Whampoa has actively engaged in the telecommunications industry through buying and selling businesses, often through complex organisational structures. A second finding is that the company has been very successful in the past at building and selling mobile operations, though it is unlikely to be as successful with its current series of 3G investments.Research limitations/implicationsSome of the data used in the paper are hard to establish with certainty.Practical implicationsThe ownership of service providers and the services available may change as Hutchison Whampoa manages its portfolio of telecommunication investments.Social implicationsAs a late entrant in many markets, Hutchison Whampoa has aggressively sought to capture market share, resulting in new services and lower prices. Whether this will continue in the future is uncertain.Originality/valueThere are no other case studies of Hutchison Whampoa's involvement in the telecommunications industry in the public domain.