bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of pulmonary hypertension related to systemic sclerosis by an index based on simple clinical observations
Authors: Meune Christophe , Avouac Jérôme , Airò Paolo , Beretta Lorenzo , Dieudé Philippe , Wahbi Karim , Caramaschi Paola , Tiev Kiet , Cappelli Susanna , Diot Elisabeth , Vacca Alessandra , Cracowski Jean‐Luc , Sibilia Jean , Kahan André , Matucci‐Cerinic Marco , Allanore Yannick 
Published: May 2011

AbstractObjectiveTo develop a score to estimate the risk of developing pulmonary hypertension (PH) in patients with systemic sclerosis (SSc).MethodsWe first examined the prevalence and characteristics of precapillary PH confirmed by right‐heart catheterization in a cross‐sectional (derivation) sample of 1,165 SSc patients, and we developed a risk prediction score (RPS) based on simple clinical observations associated with PH. We next prospectively tested the 3‐year predictive power of the “Cochin RPS” in a separate (validation) sample of 443 patients presenting with PH‐free SSc at baseline.ResultsIn the derivation sample, age, forced vital capacity, and diffusing capacity for carbon monoxide/alveolar volume were independently associated with the presence of PH and were used to create the Cochin RPS. PH developed during followup in 20 patients in the validation sample. The area under the receiver operating characteristic curve of the Cochin RPS was 0.87 (95% confidence interval 0.79–0.95). With a cutoff value of 2.73, patients at risk of PH during followup could be identified with 89.5% sensitivity and 74.1% specificity. PH occurred in 0.6% of patients in the lowest 2 quintiles of the Cochin RPS, in 1.7% of patients in the third and fourth quintiles, and in 17.1% of patients in the highest quintile (P < 0.0001 by log rank test). Patients in the highest quintile incurred a >35‐fold higher risk of developing PH compared with patients in the 2 lowest quintiles (P = 0.001).ConclusionUsing routine clinical observations, we developed a simple score that accurately predicted the risk of PH in SSc.
Epidemiology of generalized joint laxity (hypermobility) in fourteen‐year‐old children from the UK: A population‐based evaluation
Authors: Clinch Jacqui , Deere Kevin , Sayers Adrian , Palmer Shea , Riddoch Chris , Tobias Jonathan H. , Clark Emma M. 
Published: May 2011

AbstractObjectiveAlthough diagnostic criteria for generalized ligamentous laxity (hypermobility) in children are widely used, their validity may be limited, due to the lack of robust descriptive epidemiologic data on this condition. The present study was undertaken to describe the point prevalence and pattern of hypermobility in 14‐year‐old children from a population‐based cohort.MethodsWe performed a cross‐sectional analysis using the Avon Longitudinal Study of Parents and Children, a large population‐based birth cohort. Hypermobility among children in the cohort (mean age 13.8 years) was measured using the Beighton scoring system. Objective measures of physical activity were ascertained by accelerometry. Data on other variables, including puberty and socioeconomic status, were collected. Simple prevalence rates were calculated. Chi‐square tests and logistic regression analyses were used to assess associations of specific variables with hypermobility.ResultsAmong the 6,022 children evaluated, the prevalence of hypermobility (defined as a Beighton score of ≥4 [i.e., ≥4 joints affected]) in girls and boys age 13.8 years was 27.5% and 10.6%, respectively. Forty‐five percent of girls and 29% of boys had hypermobile fingers. There was a suggestion of a positive association between hypermobility in girls and variables including physical activity, body mass index, and maternal education. No associations were seen in boys.ConclusionWe have shown that the prevalence of hypermobility in UK children is high, possibly suggesting that the Beighton score cutoff of ≥4 is too low or that this scoring is not appropriate for use in subjects whose musculoskeletal system is still developing. These results provide a platform to evaluate the relationships between the Beighton criteria and key clinical features (including pain), thereby testing the clinical validity of this scoring system in the pediatric population.
Changes in the bacterial community structure and diversity during bamboo retting
Authors: Fu Jiajia , Mueller Henry , de Castro Joao V , Yu Chonewen , Cavaco‐Paulo Artur , Guebitz Georg M. , Nyanhongo Gibson S. 
Published: May 2011

AbstractMicrobial retting is a critical step in obtaining fiber bundles from bamboo culm using indigenous microorganisms. A cultivation‐independent technique for monitoring the changes in bacteria community during bamboo retting was applied in this work. This technique involves genetic profiling of PCR‐amplified small‐subunit rRNA and the single‐strand conformation polymorphism (SSCP) gel analysis of the PCR‐amplified 16S rDNA fragments. The study revealed that both the structure and the diversity of investigated communities varied with the incubation periods and sample locations. The bacteria bands from SCCP gel profiles related to Bacillus sp. decreased in intensity, and Phaeospirillum sp. and Azospirillum brasilense completely disappeared during the 4th and 5th month of incubation, while the bands related to the Sphingomonas japonica, Alphaproteobacterium Ellin335 and Microbacterium sp. increased. The bands closely related to Sphingomonads, Brevundimonas brasilense, Pseudoclavibacter sp., Agrococcus jenensis and Oxalophagus oxalicus remained dominant during the whole incubation period. This study showed that the use of PCR assay targeting 16S rRNA and SCCP profiling provided valuable information on monitoring the bacteria dynamic changes occurring in the bacteria community during bamboo retting, which is crucial for controlling the quality of the retting process and improving the retting efficiency, and thus benefits for fiber recovery.
Osseous microarchitecture of the scaphoid: Cadaveric study of regional variations and clinical implications
Authors: Su‐Bum A. Lee , Hyo‐Jin B. Kim , Jae‐Myeung C. Chun , Choon‐Sung D. Lee , Shin‐Yoon E. Kim , Poong‐Taek F. Kim , In‐Ho G. Jeon 
Published: May 2011

AbstractBone strength and structure are closely associated with fracture and screw fixation, however osseous micro architecture on scaphoid has not been clearly addressed. We conducted histomorphometric study of the scaphoid using micro CT to find regional variations and differences in the scaphoid to provide better understanding of fracture mechanism and suggest optimal screw position. We divided scaphoid into eight regions and collected regional data from eleven different cadaveric scaphoids. A computer program was used to measure parameters, which includes mean subchondral bone thickness, bone mineral density for bone density parameters, and tissue mineral density, trabecular thickness, trabecular spacing, trabecular number and bone volume fraction for bone quality parameters. All bone strength parameters were measured the maximum value in the regions where scaphoid articulates with radius. Articular regions presented higher bone strength parameters and thicker subchondral bone. The minimum value of trabecular number was in midcarpal side of waist portion. There was trend of higher subchondral bone thickness in the scaphoid which articulates with capitate and radius. This histomorphometric study showed regional variation of the scaphoid in terms of bone density and quality parameters. Waist portion presented thick subchondral and trabecular bone for high cross section moment of inertia against bending. Three point bending for scaphoid fracture and vertical screw placement are suggested based on these variations. Clin. Anat. 25:203–211, 2012. © 2011 Wiley‐Liss, Inc.
Validating the EXCEL hypothesis: A propensity score matched 3‐year comparison of percutaneous coronary intervention versus coronary artery bypass graft in left main patients with SYNTAX score ≤32
Authors: Capodanno Davide , Caggegi Anna , Capranzano Piera , Cincotta Glauco , Miano Marco , Barrano Gionbattista , Monaco Sergio , Calvo Francesco , Tamburino Corrado 
Published: May 2011

AbstractObjectives: The aim of this study is to verify the study hypothesis of the EXCEL trial by comparing percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) in an EXCEL‐like population of patients. Background: The upcoming EXCEL trial will test the hypothesis that left main patients with SYNTAX score ≤32 experience similar rates of 3‐year death, myocardial infarction (MI), or cerebrovascular accidents (CVA) following revascularization by PCI or CABG. Methods: We compared the 3‐year rates of death/MI/CVA and death/MI/CVA/target vessel revascularization (MACCE) in 556 patients with left main disease and SYNTAX score ≤32 undergoing PCI (n = 285) or CABG (n = 271). To account for confounders, outcome parameters underwent extensive statistical adjustment. Results: The unadjusted incidence of death/MI/CVA was similar between PCI and CABG (12.7% vs. 8.4%, P = 0.892), while MACCE were higher in the PCI group compared to the CABG group (27.0% vs. 11.8%, P < 0.001). After propensity score matching, PCI was not associated with a significant increase in the rate of death/MI/CVA (11.8% vs. 10.7%, P = 0.948), while MACCE were more frequently noted among patients treated with PCI (28.8% vs. 14.1%, P = 0.002). Adjustment by means of SYNTAX score and EUROSCORE, covariates with and without propensity score, and propensity score alone did not change significantly these findings. Conclusions: In an EXCEL‐like cohort of patients with left main disease, there seems to be a clinical equipoise between PCI and CABG in terms of death/MI/CVA. However, even in patients with SYNTAX score ≤32, CABG is superior to PCI when target vessel revascularization is included in the combined endpoint. © 2011 Wiley‐Liss, Inc.
Successful retrieval of an entrapped rotablator burr using 5 Fr guiding catheter
Authors: Kimura Masayoshi , Shiraishi Jun , Kohno Yoshio 
Published: May 2011

AbstractBackground: Although burr entrapment is a rare complication of the Rotablator, it is extremely difficult to retrieve a fixedly entrapped burr without surgical procedure. Case Report: An 84‐year‐old male with effort angina had heavily calcified coronary trees as well as severe stenosis in the mid LCx, and moderate stenosis in the proximal LCx, and in the LMT. We planned to perform rotational atherectomy in the LCx lesions. Using 7 Fr Q‐curve guiding catheter and Rotawire floppy, we began to ablate using 1.5‐mm burr at 200,000 rpm. Because the burr could not pass the proximal stenosis, we exchanged the wire for Rotawire extrasupport and the burr for 1.25‐mm burr, and restarted the ablation at 220,000 rpm. Although the burr could manage to pass the proximal stenosis, it had become trapped in the mid LCx lesion. Simple pull on the Rotablator, rotation of the burr, and crossing the Conquest (Confianza) wire could not retrieve it. Thus, we cut off the drive shaft and sheath of the Rotablator, inserted 5 Fr 120‐cm straight guiding catheter (Heartrail ST01; Terumo) through the remaining Rotablator system, pushed the catheter tip to the lesion around the burr as well as simultaneously pulled the Rotablator, and finally could retrieve it. Then we implanted stents in the LCx and in the LMT without difficulty. Conclusions: The 5 Fr straight guiding catheter might be useful for retrieving an entrapped burr (1.25‐mm burr). © 2011 Wiley‐Liss, Inc.
Concentration of Natural Vitamin E Using a Continuous Countercurrent Supercritical CO2 Extraction‐Distillation Dual Column
Authors: Shi B. , Jin J. , Yu E. , Zhang Z. 
Published: May 2011

AbstractA continuous countercurrent supercritical CO2 extraction‐distillation dual‐column process was developed to extract and concentrate natural vitamin E (VE) from soybean oil deodorizer distillate (SODD). The experimental results demonstrated that process parameters such as extraction pressure, temperature, and solvent‐to‐feed ratio significantly impacted on the extraction efficiency of natural VE. A new five‐parameter mass transfer model for the continuous countercurrent supercritical CO2 extraction‐distillation dual‐column process was presented based on the Penetration and Double‐Film theories. The calculated values of the mathematical model agreed well with the experimental data, with absolute average relative deviation values of less than 25 %.
Contiguous Metal‐Mediated Base Pairs Comprising Two AgIIons
Authors: Megger Dominik A. , Fonseca Guerra Célia , Hoffmann Jan , Brutschy Bernhard , Bickelhaupt F. Matthias , Müller Jens 
Published: May 2011

AbstractThe incorporation of transition‐metal ions into nucleic acids by using metal‐mediated base pairs has proved to be a promising strategy for the site‐specific functionalization of these biomolecules. We report herein the formation of Ag+‐mediated Hoogsteen‐type base pairs comprising 1,3‐dideaza‐2′‐deoxyadenosine and thymidine. By defunctionalizing the Watson–Crick edge of adenine, the formation of regular base pairs is prohibited. The additional substitution of the N3 nitrogen atom of adenine by a methine moiety increases the basicity of the exocyclic amino group. Hence, 1,3‐dideazaadenine and thymine are able to incorporate two Ag+ions into their Hoogsteen‐type base pair (as compared with one Ag+ion in base pairs with 1‐deazaadenine and thymine). We show by using a combination of experimental techniques (UV and circular dichroism (CD) spectroscopies, dynamic light scattering, and mass spectrometry) that this type of base pair is compatible with different sequence contexts and can be used contiguously in DNA double helices. The most stable duplexes were observed when using a sequence containing alternating purine and pyrimidine nucleosides. Dispersion‐corrected density functional theory calculations have been performed to provide insight into the structure, formation and stabilization of the twofold metalated base pair. They revealed that the metal ions within a base pair are separated by an Ag⋅⋅⋅Ag distance of about 2.88 Å. The Ag–Ag interaction contributes some 16 kcal mol−1to the overall stability of the doubly metal‐mediated base pair, with the dominant contribution to the Ag–Ag bonding resulting from a donor–acceptor interaction between silver 4d‐type and 4s orbitals. These Hoogsteen‐type base pairs enable a higher functionalization of nucleic acids with metal ions than previously reported metal‐mediated base pairs, thereby increasing the potential of DNA‐based nanotechnology.
New 8‐Amino‐BODIPY Derivatives: Surpassing Laser Dyes at Blue‐Edge Wavelengths
Authors: Bañuelos Jorge , Martín Virginia , Gómez‐Durán C. F. Azael , Córdoba Ismael J. Arroyo , Peña‐Cabrera Eduardo , García‐Moreno Inmaculada , Costela Ángel , Pérez‐Ojeda M. Eugenia , Arbeloa Teresa , Arbeloa Íñigo López 
Published: May 2011

AbstractThe development of highly efficient and stable blue‐emitting dyes to overcome some of the most important shortcomings of available chromophores is of great technological importance for modern optical, analytical, electronic, and biological applications. Here, we report the design, synthesis and characterization of new tailor‐made BODIPY dyes with efficient absorption and emission in the blue spectral region. The major challenge is the effective management of the electron‐donor strength of the substitution pattern, in order to modulate the emission of these novel dyes over a wide spectral range (430–500 nm). A direct relationship between the electron‐donor character of the substituent and the extension of the spectral hypsochromic shift is seen through the energy increase of the LUMO state. However, when the electron‐donor character of the substituent is high enough, an intramolecular charge‐transfer process appears to decrease the fluorescence ability of these dyes, especially in polar media. Some of the reported novel BODIPY dyes provide very high fluorescence quantum yields, close to unity, and large Stokes shifts, leading to highly efficient tunable dye lasers in the blue part of the spectrum; this so far remains an unexploited region with BODIPYs. In fact, under demanding transversal pumping conditions, the new dyes lase with unexpectedly high lasing efficiencies of up to 63 %, and also show high photostabilities, outperforming the laser action of other dyes considered as benchmarks in the same spectral region. Considering the easy synthetic protocol and the wide variety of possible substituents, we are confident that this strategy could be successfully extended for the development of efficient blue‐edge emitting materials and devices, impelling biophotonic and optoelectronic applications.
Thermodynamics, Structure and Properties of Polynuclear Lanthanide Complexes with a Tripodal Ligand: Insight into their Self‐Assembly
Authors: Hamacek Josef , Besnard Céline , Penhouet Tiphaine , Morgantini Pierre‐Yves 
Published: May 2011

AbstractSelf‐assembly processes between a tripodal ligand and LnIII cations have been investigated by means of supramolecular analytical methods. At an equimolar ratio of components, tetranuclear tetrahedral complexes are readily formed in acetonitrile. The structural analysis of the crystallographic data shows a helical wrapping of binding strands around metallic cations. The properties of this series of highly charged 3D compounds were examined by using NMR spectroscopy and optical methods in solution and in the solid state. In the presence of excess metal, a new trinuclear complex was identified. The X‐ray crystal structure elucidated the coordination of metallic cations with two ligands of different conformations. By varying the metal/ligand ratio, a global speciation of this supramolecular system has been evidenced with different spectroscopic methods. In addition, these rather complicated equilibria were successfully characterised with the thermodynamic stability constants. A rational analysis of the self‐assembly processes was attempted by using the thermodynamic free energy model and the impact of the ligand structure on the effective concentration is discussed.
Chemical and Thermal Stability of Isotypic Metal–Organic Frameworks: Effect of Metal Ions
Authors: Kang In Joong , Khan Nazmul Abedin , Haque Enamul , Jhung Sung Hwa 
Published: May 2011

AbstractChemical and thermal stabilities of isotypic metal–organic frameworks (MOFs) like Al‐BDC (Al‐benzenedicarboxylate called MIL‐53‐Al), Cr‐BDC (MIL‐53‐Cr) and V‐BDC (MIL‐47‐V), after purification to remove uncoordinated organic linkers, have been compared to understand the effect of the central metal ions on the stabilities of the porous MOF‐type materials. Chemical stability to acids, bases, and water decreases in the order of Cr‐BDC>Al‐BDC>V‐BDC, suggesting stability increases with increasing inertness of the central metal ions. However, thermal stability decreases in the order of Al‐BDC>Cr‐BDC> V‐BDC, and this tendency may be explained by the strength of the metal–oxygen bond in common oxides like Al2O3, Cr2O3, and V2O5. In order to evaluate precisely the stability of a MOF, it is necessary to remove uncoordinated organic linkers that are located in the pores of the MOF, because a filled MOF may be more stable than the same MOF after purification.
ChemInform Abstract: Crystal Structure and Phase Transition of Single Crystalline CsNH2SO3.
Authors: Fukami T. , Kyan T. , Nakano K. , Chen R. H. 
Published: May 2011

AbstractSingle crystals of the title compound are prepared at room temperature by slow evaporation of aqueous solutions containing stoichiometric amounts of Cs2CO3 and NH2SO3H.
ChemInform Abstract: Sr2Ni3 — A Strontium Subnickelide?
Authors: Hoehn Peter , Agrestini Stefano , Baranov Alexey , Hoffmann Stefan , Kohout Miroslav , Nitsche Fabian , Wagner Frank R. , Kniep Ruediger 
Published: May 2011

AbstractThe title compound is obtained from a stoichiometric mixture of the elements (Nb tube, 600 °C, 48 h) and characterized by powder XRD and scalar‐relativistic all‐electron full‐potential DFT calculations.
ChemInform Abstract: CdWO4 Polymorphs: Selective Preparation, Electronic Structures, and Photocatalytic Activities.
Authors: Yan Tingjiang , Li Liping , Tong Wenming , Zheng Jing , Wang Yunjian , Li Guangshe 
Published: May 2011

AbstractCdWO4 polymorphs are solvothermally synthesized from mixtures of Cd2Cl2 and Na2WO4 using water as solvent to prepare monoclinic CdWO4, and propylene glycol for tetragonal CdWO4 (autoclave, 200 °C, 10 h).
ChemInform Abstract: Substrate‐Controlled Regioselective Cobalt(I)‐Catalyzed 1,4‐Hydrovinylation Reactions.
Authors: Hilt Gerhard , Roesner Stefan 
Published: May 2011

AbstractThe regioselectivity of unsymmetrical dienes is controlled by the steric hindrance of the substituents in 2‐ and 3‐position.
ChemInform Abstract: PhI(OAc)2‐Mediated Iminobromination for Synthesis of Bromomethyl Cyclic Imines Starting from Alkenyl Carbonitriles and Grignard Reagents.
Authors: Sanjaya Stephen , Chiba Shunsuke 
Published: May 2011

AbstractA wide range of alkenyl carbonitriles smoothly undergoes nucleophilic addition of aryl or alkenyl Grignard reagents to generate N—H imines.
ChemInform Abstract: Ru‐Catalyzed Activation of sp3 C—O Bonds: O‐ to N‐Alkyl Migratory Rearrangement in Pyridines and Related Heterocycles.
Authors: Yeung Charles S. , Hsieh Tom H. H. , Dong Vy M. 
Published: May 2011

AbstractA novel and distinct strategy for sp3 etheral C—O bond activation towards the preparation of N‐alkylated 2‐pyridones and related heterocycles is developed.
ChemInform Abstract: Selective Reduction of Organic Compounds with Al‐Trifluoromethanesulfonyldiisobutylalane. Comparison of Its Reactivity with Al‐Methanesulfonyldiisobutylalane.
Authors: Cha Jin Soon 
Published: May 2011

AbstractDiisobutylaluminum triflate shows higher reactivity and diastereoselectivity in the reduction of cyclic ketones (I) and (IV) compared to diisobutylaluminum mesylate.
ChemInform Abstract: The Heck Reaction of Allylic Alcohols Catalyzed by Palladium Nanoparticles in Water: Chemoenzymatic Synthesis of (R)‐(‐)‐Rhododendrol.
Authors: Boffi Alberto , Cacchi Sandro , Ceci Pierpaolo , Cirilli Roberto , Fabrizi Giancarlo , Prastaro Alessandro , Niembro Sandra , Shafir Alexandr , Vallribera Adelina 
Published: May 2011

AbstractThe use of phosphine‐free palladium nanoparticles immobilized on fluorous silica gel in the Heck reaction of aryl iodides with allylic alcohols in water is described.
ChemInform Abstract: A Facile and Practical Copper Powder‐Catalyzed Organic Solvent‐ and Ligand‐Free Ullmann Amination of Aryl Halides.
Authors: Jiao Jiao , Zhang Xi‐Ru , Chang Ning‐Hui , Wang Jie , Wei Jun‐Fa , Shi Xian‐Ying , Chen Zhan‐Guo 
Published: May 2011

AbstractThe reaction with NH3 and primary aliphatic amines proceeds efficiently.
ChemInform Abstract: Pd‐Catalyzed Carbonylative Reactions of Aryl Iodides and Alkynyl Carboxylic Acids via Decarboxylative Couplings.
Authors: Park Ahbyeol , Park Kyungho , Kim Yong , Lee Sunwoo 
Published: May 2011

AbstractAs low as 0.5mol% of the Pd catalyst is required for the title reaction.
ChemInform Abstract: Preparation of Heterocyclic Amines by an Oxidative Amination of Zinc Organometallics Mediated by CuI: A New Oxidative Cycloamination for the Preparation of Annulated Indole Derivatives.
Authors: Kienle Marcel , Wagner Andreas J. , Dunst Cora , Knochel Paul 
Published: May 2011

AbstractFunctionalized heterocyclic zinc reagents are easily synthesized by a facile oxidative amination of zinc amidocuprate intermediates prepared from various lithium amides.
ChemInform Abstract: Ammonium Ylides for the Diastereoselective Synthesis of Glycidic Amides.
Authors: Waser Mario , Herchl Richard , Mueller Norbert 
Published: May 2011

AbstractA highly trans‐selective protocol for the synthesis of glycidic amides based on the reaction of stabilized DABCO ammonium ylides bearing an α‐carbonyl group with aromatic aldehydes is developed.