bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between Pre-Kidney Transplantation Elevated Parathyroid Hormone and Posttransplantation Graft Loss
Authors: Crepeau Philip K , Liu Yi , Done Joy Z , Foote Darci , Brennan Daniel C , Morris-Wiseman Lilah F , Segev Dorry L , McAdams-DeMarco Mara , Mathur Aarti 
Published: June 2024

BACKGROUND:
Before kidney transplantation (KT), most patients have an elevated parathyroid hormone (PTH). However, the impact of PTH on post-KT mortality and graft loss is unclear. We quantified the association between PTH levels measured at transplantation and adverse post-KT outcomes.

STUDY DESIGN:
We leveraged a prospective longitudinal cohort of 1,136 KT recipients from a single tertiary care center between December 2008 and February 2020. Pre-KT PTH levels were abstracted retrospectively. Adjusted multivariable Cox proportional hazards models were used to estimate the association between pre-KT PTH levels and mortality and death-censored graft loss (DCGL).

RESULTS:
Of 1,136 recipients, pre-KT PTH levels were 300 pg/mL or less in 62.3% and more than 600 pg/mL in 12.5%. Compared with those with a pre-KT PTH 300 pg/mL or less, patients with a pre-KT PTH more than 600 pg/mL were more likely to be Black (51.4% vs 34.6%) and have a longer dialysis vintage (4.8 vs 1.7 years, p < 0.001). Those with a pre-KT PTH more than 600 pg/mL had a higher 10-year cumulative incidence of DCGL than those with PTH 300 pg/mL or less (31.7% vs 15.4%, p < 0.001). After adjusting for confounders, pre-KT PTH more than 600 pg/mL was associated with a 1.76-fold increased risk of DCGL (95% CI 1.16 to 2.65). The magnitude of this association differed by race (pinteraction = 0.011) and by treatment (pinteraction = 0.018). Among non-Black patients, a PTH more than 600 pg/mL was associated with a 3.21-fold increased risk of DCGL compared with those with PTH 300 pg/mL or less (95% CI 1.77 to 5.81). Among untreated patients, those with PTH more than 600 pg/mL had a 2.54-fold increase in DCGL (95% CI 1.44 to 4.47). No association between pre-KT PTH and mortality risk was observed.

CONCLUSIONS:
PTH more than 600 pg/mL before KT increased the risk of DCGL by 76%, demonstrating the importance of treating PTH before KT to prevent graft loss in a contemporary era with the introduction and widespread availability of medical therapy.
Urine Proteomics in Methamphetamine Addicted Patients
Authors: Shen Ziyun , Liang Juncheng , Tang Shuxuan , Pan Xuanzhen , Bao Yijin , Deng Yanping , Gao Youhe 
Published: June 2024

ABSTRACTDrug addiction is a serious chronic relapsing brain disease, and methamphetamine dependence has a complex course and is difficult to treat, causing a serious public health burden. In this study, we compared and analyzed the urine proteome of methamphetamine-using patients, methamphetamine-withdrawing patients, healthy individuals. The urine proteome of methamphetamine-using patients and methamphetamine-withdrawing patients was significantly different from that of healthy individuals, and some differential proteins and their enriched biological functions showed that they were associated with addiction or neurotoxicity of methamphetamine. The fact, that the urine proteome of patients who withdrew methamphetamine for more than 3 months were significantly different from that of healthy patients, may reveal the reasons for the high rate of methamphetamine relapse and potential intervention targets. This study proved that urine proteome can reflect the effects of addiction on the body comprehensively, and has the potential to provide clues for addiction.
Underground Guardians: How Collagen and Chitin Amendments Shape Soil Microbiome Structure and Function forMeloidogyne enterolobiiControl
Authors: Pasche Josephine , Sawlani Roshni , Buttrós Victor Hugo , Desaeger Johan , Garret Karen , Martins Samuel J. 
Published: June 2024

AbstractThe emergence of the Guava Root-Knot Nematode (Meloidogyne enterolobii) poses a significant threat to tomato yields globally. This study aimed to evaluate the impact of collagen and chitin soil amendments on soil microbial composition and function (fungal and bacterial communities), and their effects on tomato plant health andM. enterolobiiinfection under standard (5,000 eggs plant-1) and high (50,000 eggs plant-1) inoculum pressure. Conducted in a greenhouse setting, the study investigated the effectiveness of these amendments in nurturing beneficial microbial communities across both native and agricultural soils. Both collagen and chitin were effective in reducing nematode egg counts up to 66% and 84% under standard and high inoculum pressure, respectively and enhance plant health parameters (biomass and chlorophyll content). Moreover, a microbiome shift led to an increase in bacterial (Kitasatospora, Bacillus, and Streptomyces) and fungal (Phialemonium) genera, known for their chitinase, collagenase, and plant-parasitic nematode control. Among the microbes,Streptomycesspp. were found among the core microbiome and associated with a lower disease incidence assessed through a phenotype-OTU network analysis (PhONA). Under standard inoculum a higher metabolite expression was observed with the amino acid class being the majority among the metabolite groups. The findings highlight the potential of collagen and chitin to mitigateMeloidogyne enterolobiiinfection by fostering beneficial soil microbial communities.
Enhancing precision and efficiency in English bond brick masonry: novel unified templates approach
Authors: Mehta Vikas , Thakur Mohindra Singh 
Published: June 2024

PurposeThis study aims to enhance the precision and efficiency of English Bond brick masonry by developing three unified templates: Tc, T1, and T2. These templates are designed to address the complexities in the placement of bricks, particularly queen closers and brickbats, in English Bond patterns.Design/methodology/approachThe research introduces a unique numbering system integrated within each template to facilitate accurate brick placement. Template Tc is designed explicitly for corner masonry, while T1 and T2 are developed for linear masonry along the X and Y directions, respectively. The approach standardizes the bricklaying process, ensuring proper alignment and bricks overlap.FindingsApplying these templates significantly improves the efficiency and pace of English bond brick masonry. They simplify the construction process, reduce errors, and enhance the overall quality of masonry work. The study demonstrates that using these templates results in consistent and high-quality brickwork, surpassing traditional speed, efficiency, and accuracy methods.Originality/valueThis study contributes a novel, systematic approach to bricklaying in English Bond masonry. The introduction of unified templates aids in skill acquisition for professionals and learners, ensuring flawless execution of masonry projects. This innovative approach holds great value in modern construction practices, promoting standardization and excellence in masonry work.
Monthly seller’s bargaining power index constructed using open-source data
Authors: Zhang Xingrui , Xu Shuai , Wang Yunpeng , Yang Eunhwa 
Published: June 2024

Purpose
A tangible representation of the housing market hotness, namely, the index derived via Carrilo 2013’s concept, is widely used but difficult to construct, as it requires listing data of a geography which is not only inaccessible but also cumbersome to summarize. The purpose of this paper is to serve as a methodological extension of Carrilo 2013, presenting a process by which the seller’s bargaining power index can be easily constructed using open-source data.

Design/methodology/approach
The seller’s bargaining power index was first constructed using the open-source data by Zillow Research. Then, results verification approach including visualization, Pearson correlation test, Granger causality test and linear regression were used with the goal to generate empirical evidence and verify if the constructed index conforms with established relationships derived in past work, thereby substantiate accuracy of the constructed index.

Findings
Monthly seller’s bargaining power index was constructed for US as a whole and 250 metropolitan statistical areas through an automated process. The constructed index conforms with established evidence in terms of seasonality, trend and magnitude. The index also forms positive correlation with building permit/housing value/housing value increase rate, and negative correlation with inventory. It requires the explanatory power of multiple linear features to simulate the parameter. Seller’s bargaining power index at a national level can serve as a general indicator of economic strength, in parallel to number of building permit, housing starts and real gross domestic product. Quantitatively, the housing market of the USA is as “hot” during the COVID-19 pandemic as it was in the years before 2008. A healthy housing market appears to be one in which 75%−80% of the deals are in favor of the seller (take-it-or-leave-it). When said percentage reaches 90%, the market should be considered to be in a “bubble.”

Originality/value
This paper provides an easy pathway for future studies to simulate housing market hotness, and bring upon the benefit of convenience at low cost and in monthly frequency rather than quarterly or annually.
Toxicity in the trans debate: what are the psychological phenomena that turn an issue of mental health and social inclusion into a forum for vitriolically vicious social exclusion?
Authors: MacLennan Nigel 
Published: June 2024

Purpose
This study aims to explore and document some of the phenomena that seem to have toxified the trans debate.

Design/methodology/approach
To create a partial compilation of the phenomena most known to cloud human judgement and reasoning, using the trans debate as the prime example.

Findings
The trans debate seems to have been increasingly toxified in ways predicted by well-documented psychological phenomena.

Research limitations/implications
Although much is known about the psychological toxifiers on an individual basis, little is known about how they interact to cause the emergence and amplification of toxic debate.

Practical implications
It is anticipated by studying the emergence of the toxicity around the trans debate, that the descent into toxic discourse in many other contexts can be better understood.

Social implications
If lessons can be learnt from the descent into toxicity in the trans debate, and its participants become aware of their behaviour, perhaps they can better work towards a mutually acceptable solution.

Originality/value
By compiling the factors responsible for the toxification of debate, it is hoped that what appear to be the precursors of all conflict and war can be better understood, prevented or avoided.
Preferences for urban greenspace functions during public health pandemics. Empirical evidence from Malawi
Authors: Khataza Robertson 
Published: June 2024

Purpose
The purpose of this study was to investigate the impact of Corona virus disease on the perceived values of urban green landscapes in a developing country setting. To achieve this objective, the author investigated changes in the preferences for urban green space services among city residents who use nature areas for recreation.

Design/methodology/approach
This study applied the best–worst scaling technique to elicit changes in the preferences for ecosystem services from urban recreational sites in Malawi. The study also used a fractional logit model to examine factors that motivate visitors’ willingness to donate/contribute to improve the quality of nature’s recreational services.

Findings
This study finds that the COVID-19 pandemic changed visitors’ perceptions of urban woodlands, but leisure/recreation remained the most important service with or without the Corona virus outbreak. However, the perceived value of air pollution control and cultural/religious functions gained more prominence (+3%), whereas biodiversity conservation became less prominent (−2%) during the pandemic period. The mean willingness to pay (WTP) was estimated to be US$28.73, and WTP is positively influenced by education, income status and the user’s satisfaction with the recreation site.

Originality/value
The study substantiated the impact of Corona virus disease on the perceived values of urban green landscapes, using Malawi as a case study. This was demonstrated through the changes in preferences for urban green space services among city residents who use nature areas for recreation.
Indigenous autonomy and decentralization in Colombia's quest for peace
Authors: Mitchell Derek P. 
Published: June 2024

AbstractColombia's constitution recognizes territorial autonomy as an inalienable right of its indigenous peoples, much like other countries across Latin America. Yet, for indigenous people exercising those rights, Colombia is the most dangerous country in the world. Why do states grant extensive rights to indigenous peoples and then fail to uphold them? This article approaches that question through an analysis of decentralization amid Colombia's armed conflict. It examines how crises that prompted a decentralization of governance during the conflict created political opportunities for indigenous rights in Colombia. Subsequent shifts in the conflict, however, including competition for control of extractive industries, put indigenous autonomy at odds with all the conflicting parties' interests. To resolve these challenges, the article suggests that the politics of climate change has created new political opportunities for indigenous autonomy throughout Latin America. It calls for investing in indigenous self‐governance to both protect the environment and secure peace.
Women peacebuilders in Colombia and new digital solutions
Authors: Hustead Maggie 
Published: June 2024

AbstractWomen all over the world are using information and communications technology (ICT) to build peace in their communities. Women are natural pioneers of these technologies because the networks they use daily are the foundations that build long‐term peace in their communities. This article discusses the relationship between gender and digital connectivity, investigates whether women have different needs when building peace versus when implementing peace, and uses ICT in peacebuilding in Colombia as a case study. The Colombian government has made significant strides in closing the digital gap, especially in rural areas, and women have taken advantage of ICT to facilitate the Peace Agreement of 2016. The implementation of the peace agreement and digital solutions, however, is posing new challenges to women, including vulnerabilities in physical safety and increasing social and political polarization. Colombia needs to strengthen its efforts to close the digital divide by providing communities with the type of infrastructure and training that will meet their needs. Further, gender‐based technical policy needs to be readdressed to incorporate strategies to combat the current violence women face when using ICT. Colombia needs to prioritize providing a digital state presence to help protect women peacebuilders and hold perpetrators accountable.
NATO and the institutional reform of the Colombian armed forces
Authors: McKellips Andrew I. G. 
Published: June 2024

AbstractWhile the 2016 Peace Accords with FARC do not contain a Chapter dedicated to the reform of the Armed Forces or to the methods for securing peace by the State, the False Positives scandal and the broader consequences of the armed conflict have driven the Truth Commission to consider the role of the Armed Forces in the conflict and to recommend institutional reforms. Throughout the peacebuilding phase, the Colombian Armed Forces have been slowly reforming their institution and have made progress on a number of the focus areas identified by the Truth Commission. The epitome of this progress is Colombia's ongoing participation in the North Atlantic Treaty Organization (NATO) Building Integrity (BI) Program, which has been the anchor point in the development and growth of the NATO‐Colombia relationship and partnership since 2013. This article looks at the ongoing reforms and suggests that there is an opportunity for Colombia to leverage its established, mature relationship with NATO and the BI Program, to accomplish the desired reforms in the Armed Forces. This strategy allows the government of Colombia to co‐opt existing efforts for his own domestic agenda without alienating or discounting the progress that the Armed Forces have already made on their own.
Absorption pharmacokinetics and feasibility of intranasal dexmedetomidine in patients under general anaesthesia
Authors: Tiainen Suvi‐Maria , Anderson Brian J. , Rinne Ella , Tornio Aleksi , Engström Marica T. , Saari Teijo I. , Uusalo Panu 
Published: June 2024

AbstractBackgroundThe use of intranasal dexmedetomidine is hampered by a limited understanding of its absorption pharmacokinetics.MethodsWe examined the pharmacokinetics and feasibility of intranasal dexmedetomidine administered in the supine position to adult patients undergoing general anaesthesia. Twenty‐eight patients between 35 and 80 years of age, ASA 1–3 and weight between 50 and 100 kg, who underwent elective unilateral total hip or knee arthroplasty under general anaesthesia were recruited. All patients received 100 μg of intranasal dexmedetomidine after anaesthesia induction. Six venous blood samples (at 0, 5, 15, 45, 60, 240 min timepoints from dexmedetomidine administration) were collected from each patient and dexmedetomidine plasma concentrations were measured. Concentration‐time profiles after nasal administration were pooled with earlier data from a population analysis of intravenous dexmedetomidine (n = 202) in order to estimate absorption parameters using nonlinear mixed effects. Peak concentration (CMAX) and time (TMAX) were estimated using simulation (n = 1000) with parameter estimates and their associated variability.ResultsThere were 28 adult patients with a mean (SD) age of 66 (8) years and weight of 83 (10) kg. The mean weight‐adjusted dose of dexmedetomidine was 1.22 (0.15) μg kg−1. CMAX 0.273 μg L−1 was achieved at 98 min after intranasal administration (TMAX). The relative bioavailability of dexmedetomidine was 80% (95% CI 75–91%). The absorption half‐time (TABS = 120 min; 95% CI 90–147 min) was slower than that in previous pharmacokinetic studies on adult patients. Perioperative haemodynamics of all patients remained stable.ConclusionsAdministration of intranasal dexmedetomidine in the supine position during general anaesthesia is feasible with good bioavailability. This administration method has slower absorption when compared to awake patients in upright position, with consequent concentrations attained after TMAX for several hours.
Real‐world effectiveness and safety of bimekizumab for hidradenitis suppurativa: An ambispective observational study
Authors: Mansilla‐Polo Miguel , Pons‐Benavent Martí , Fernández‐Crehuet Pablo , Vilarrasa Eva , Albanell‐Fernández Cristina , Morales‐Tedone Enrico , Rausell‐Félix Francisca , Alcalá‐García Rebeca , Matellanes‐Palacios María , Martín‐Ezquerra Gemma , Alfageme Fernando , Ciudad‐Blanco Cristina , López‐Villaescusa María Teresa , Garbayo‐Salmons Patricia , Martorell Antonio , Escutia‐Muñoz Begoña , Navarro‐Blanco Fernando , Martín‐Torregrosa Daniel , Cuenca‐Barrales Carlos , Molina‐Leyva Alejandro , Botella‐Estrada Rafael 
Published: June 2024

AbstractIn this original research, we present the results in terms of effectiveness and safety of bimekizumab for hidradenitis suppurativa in real clinical practice. Results indicated significant improvement in all activity scores and patient‐reported outcomes at week 16, including a notable decrease in mean IHS4 from 27.1 to 15.6 (p < 0.001), HS‐PGA from 5.1 to 3.2 (p < 0.001), VAS pain from 8.3 to 4.7 (p < 0.001) and DLQI from 21.6 to 12.6 (p < 0.001). Bimekizumab, administered every 2 or 4 weeks, was well‐tolerated with no discontinuations and no new safety concerns identified. These findings corroborate the drug's effectiveness and favourable safety profile observed in phase 3 clinical trials, supporting its use in real‐world clinical practice for treating HS.
Signs of the sacred at the sanctuary of Gravisca, Italy: reconstruction of an Etruscan ritual through a multidisciplinary approach
Authors: Patrizi Giulia , Rageot Maxime , Cafisso Sara , Pennetta Antonio , Fiorini Lucio , De Benedetto Giuseppe Egidio , Spiteri Cynthianne , Fiorentino Girolamo 
Published: June 2024

AbstractArchaeological campaigns carried out at the emporic sanctuary of Gravisca (Tarquinia, Italy) have revealed extraordinary evidence for ritual depositions and ceremonies linked to the divinities/guarantors of the sanctuary. The ritual of one such deposition was reconstructed using a multidisciplinary approach, comprising an in‐depth analysis of the stratigraphy and archaeobotanical and lipid biomolecular techniques. This approach helped to define the possible sequence of events and human actions that occurred during the ritual, the animal and plant offerings, how these were processed, and the season during which the ceremony took place. Lipid biomolecular analysis also suggested the presence of garum, which to date is the earliest evidence for its use in the Mediterranean area.
The initial experience of robot‐assisted transabdominal transversalis fascial and preperitoneal repair for small ventral hernia
Authors: Shimada Gen , Matsubara Taketo , Ong Marc Weijie , Sambommatsu Mariko , Sakurai Shintaro 
Published: June 2024

AbstractPurposeDespite the widespread of ventral hernia repairs globally, the approach method, dissection planes, defect closure, and the choice and placement layer of mesh are an ongoing debate. We reported the details of surgical techniques, safety and feasibility for robot‐assisted transabdominal transversalis fascial and preperitoneal repair (R‐TATFPP) for small ventral hernia.MethodsThis study included 5 cases of R‐TATFPP repair among 22 cases performed by robot‐assisted ventral hernia repair from 2018 to 2023 with the approval of the Institutional Review Board at St. Luke's International University and clinical ethical committee at St. Luke's International Hospital (19‐R147, 22–012).ResultsThere were four males and one female, with mean age of 64.4 ± 10.0 years, inclusive of two umbilical and three incisional hernias. Mean height, weight, body mass index (BMI), hernia defect length, width, operation time, console time, and hospital stay were 171.2 ± 11.8 cm, 82.4 ± 13.4 kg, 28.0 ± 2.1 kg/m2, 2.8 ± 1.4 cm, 3.0 ± 1.3 cm, 180 min, 133.8 min, and 2.4 days, respectively. No conversion nor complication was observed except for one acute urinary retention.ConclusionRobot‐assisted transversalis fascial and preperitoneal repair was safe and feasible for small ventral hernia with the minimal disruption to the abdominal wall architecture and structures.