bluuebunny/crossref_metadata_2025_split huggingface dataset:
Network models for temporal data reconstruction for dam health monitoring
Authors: Chen Yongjiang , Wang Kui , Zhao Mingjie , Liu JianFeng 
Published: February 2025

AbstractThe reconstruction of monitoring data reconstruction is an important step in the process of structural health monitoring. Monitoring data reconstruction involves generating values that are close to the true or expected values, and then using the generated values to replace the anomalous data or fill in the missing data. Deep learning models can be used to reconstruct dam monitoring data, but current models suffer from the inabilities to reconstruct data when the dataset is significantly incomplete, and the reconstruction accuracy and speed have needs for improvement. To this end, this paper proposes a dam temporal reconstruction nets (DTRN) based on generative adversarial nets, which is used to accurately reconstruct dam monitoring data for cases of incomplete datasets. To improve the accuracy of the reconstruction values, this paper embeds a gated recurrent unit network based on a sequence‐to‐sequence model into DTRN to extract the temporal features of the dam monitoring data. In addition, given that random matrices with different distributions lead to different reconstruction results, maximum probability reconstruction based on multiple filling is adopted. Finally, several experiments show that (1) DTRN is not only applicable to the reconstruction of various types of dam monitoring data (e.g., dam displacement monitoring data, dam seepage pressure monitoring data, seam gauge monitoring data, etc.) but also can be applied to other relatively smooth time series data. (2) The average root mean square error of DTRN (0.0618) indicates that its accuracy is 92.3%, 57.5%, and 71.99% higher than that of generative adversarial imputation nets (GAIN), timing GAIN (TGAIN), and dam monitoring data reconstruction network (DMDRN), respectively. (3) The average elapsed time of DTRN (522.6 s) is 68.45% and 48.10% shorter than that of TGAIN and DMDRN, respectively.
Extranuclear function of Arabidopsis HOOKLESS1 regulates pleiotropic developmental processes in a non‐cell‐autonomous manner
Authors: Nobusawa Takashi , Matsushima Naoya , Ueda Hiroaki , Yumoto Emi , Asahina Masashi , Kusaba Makoto 
Published: February 2025

Summary
N‐acetyltransferase HOOKLESS1 (HLS1) in Arabidopsis, a recognized pivotal factor in hook formation, is also implicated in multifaceted developmental processes including plastochron and leaf senescence. However, its molecular function remains to be elucidated.
We utilized LC‐MS for plant hormone quantification and implemented a series of molecular genetic and physiological approaches to analyze HLS1 functions.
Our findings indicate that HLS1 functions in tissues distant from its expression sites in the regulation of apical hook formation, plastochron, and leaf senescence, implying its non‐cell‐autonomous mode of action. We observed that extranuclear localization of HLS1 can complement the hls1 phenotype, suggesting a revision of our understanding that HLS1 is a nuclear‐specific histone acetyltransferase. The double mutant of HLS1 and its paralog shows highly pleiotropic and enhanced phenotypes similar to those of the double mutant of the putative carboxypeptidase gene ALTERED MERISTEM PROGRAM1 (AMP1) and its paralog. Genetic analysis revealed that HLS1 and AMP1 act in the same genetic pathway to regulate the plastochron. No significant differences in the contents of known plant hormones were observed in the hls1 mutant.
HLS1 is an N‐acetyltransferase that functions in a non‐cell‐autonomous manner across pleiotropic developmental phenomena in conjunction with AMP1, potentially independent of known plant hormone signaling.
Prevalence of overweight and obesity in incarcerated individuals in developed and developing countries: A systematic review and meta‐analysis
Authors: Mosomi Leonida Nyarwaba , Aceves‐Martins Magaly , Johnstone Alexandra M. , de Roos Baukje 
Published: February 2025

SummaryWe systematically assessed evidence of overweight and obesity prevalence, and possible determinants, in people who experience incarceration globally. We searched Embase, Medline, and Cochrane databases. Overweight and obesity proportions were pooled into a meta‐analysis and compared with national prevalences.Seventy‐one studies met the inclusion criteria; 38 were included in the meta‐analysis. Studies in high‐income countries reported higher proportions of overweight and obesity (73.3%, 95% CI 73.1, 73.5) than upper‐middle‐income countries (66.1%, 95% CI 64.1, 67.7) and lower‐middle‐income countries (52.8%, 95% CI 47.1, 58.1). The prevalence of overweight and obesity in female incarcerated individuals was higher than that in the general population (RD 11.7%, 95% CI 9.1, 14.3), especially in low and middle‐income countries (RD 35.1%, 95% CI 29.4, 40.7). The prevalence of overweight and obesity in male incarcerated individuals was lower than that in the general population in all income categories (RD ‐10.8%, 95% CI ‐13.2, −8.4). Incarcerated individuals in low and lower‐middle‐income countries were less likely to achieve sufficient energy intake, fruit/vegetable intake, and sufficient physical activity, compared with high‐ and upper‐middle‐income countries.The prevalence of overweight and obesity in incarcerated populations differed between developed and developing countries. Future research should focus on female incarcerated individuals, especially in lower‐middle‐income countries.
The rational design of a Rhodamine fluorescent probe enables the selective detection and bioimaging of salicylic acid in plants under abiotic stress
Authors: Wang Jinjing , Yang Xiaoyan , Fan Lijun , Ye Haojie , Hao Gefei , Wang Peiyi 
Published: February 2025

SummaryAbiotic stress severely hinders plant growth and development, resulting in a considerable reduction in crop yields. Salicylic acid (SA) serves as a central signal mediating abiotic stress responses in plants. Real‐time fluorescence tracking using specific probes can enhance our understanding of the SA‐triggered modulation underlying these events. However, in complicated living plant microenvironments, selective recognition and bioimaging of SA is a great challenge for scientists due to the severe background interference and SA analogues. Herein, an efficient fluorescence probing technology employing a highly selective rhodamine probe—phoxrodam was developed, which realizes the precise bioimaging of SA in salt‐stressed plant seedlings. Experimental findings reveal that phoxrodam demonstrates exceptional selectivity (fluorescence intensity: IPhoxrodam+SA/IPhoxrodam+SA analogues > 4.29‐fold), high sensitivity (limit of detection = 6.42 nM, fluorescence quantum yield: ΦPhoxrodam+SA = 0.36) and good anti‐interference properties. Furthermore, we confirmed that phoxrodam accurately detects SA in the roots of salt‐stressed wheat seedlings, the low‐temperature resistance of Nicotiana benthamiana and the heavy metal resistance of pea seeds, using in vivo confocal imaging. This study provides a feasible strategy for efficiently tracking plant signalling molecules and promotes the in‐depth research of SA‐mediated physiological mechanisms, laying a key foundation for the future development of new immune activation inducers.
Neuropsychiatric symptom‐related role and activity restrictions by relatives: focusing on the gender of older adults with suspected dementia
Authors: Fujita Yu , Kato Yuka , Oba Hikaru , Hashimoto Nana , Narumoto Jin 
Published: February 2025

AbstractBackgroundAs cognitive function declines, relatives may restrict the roles and activities they consider older adults unable to continue independently performing. We examined the characteristics of these role and activity restrictions by relatives among older adults prior to their first visit to a memory clinic for an official diagnosis, focusing on gender and the diagnosis of dementia. Additionally, we examined the relationship between role and activity restrictions by relatives and the presence of neuropsychiatric symptoms (NPS) controlling for older adults' gender.MethodsWe retrospectively reviewed the medical charts of 213 older adults. First, we calculated descriptive statistics for the characteristics of role and activity restrictions by relatives. Second, we examined the association between these roles and activity restrictions and NPS using multivariate logistic regression analysis controlling for older adults' gender, diagnosis, and presence of a cohabitant.ResultsThe rate of role and activity restrictions by relatives was 21.6%. Of the older adults experiencing these restrictions, 78.3% were women, and 34.8% had mild cognitive impairment. The most common role and activity restriction was money‐related. Role and activity restrictions were associated with the NPS of hyperactivity, psychosis. Hyperactivity was related to men.ConclusionsHyperactivity psychosis may be more strongly related to family involvement than other NPS. These findings highlight the importance of avoiding premature role and activity restrictions among older adults with suspected dementia.
Guardians and Spenders in the Budgetary Process: More Than One Type of Relations
Authors: Shpaizman Ilana 
Published: February 2025

ABSTRACTThe budget is the outcome of bargaining between spenders and guardians. Most research on budgeting sees all spenders as a unitary actor. This article argues, instead, that there are different relations at play between guardians and each spending ministry. Based on a comparison between four social ministries in Israel, it shows that these relations differ in terms of the level of involvement of guardians in spenders' budgetary inputs and outputs, ranging from near‐complete autonomy within existing budget limits to tight budgetary control and interference in policymaking. The difference is a function of the perceived risk of overspending or ineffectiveness. When the guardian's level of involvement is high, the dynamic between the parties can be conflictual if they do not share the same policy ideas. In a conflictual dynamic, spenders have more chances of forcing their will on guardians if they can use their political power to stand up to them.
Predicting Physical Activity Intentions, Habits, and Action Plans in Finnish Parent–Child Dyads
Authors: Phipps Daniel J. , Saarinen Milla , Green Weldon T. , Lintunen Taru , Knittle Keegan , Hagger Martin S. 
Published: February 2025

ABSTRACTPhysical activity levels among early adolescents and their parents are insufficient for health benefits. Identifying modifiable determinants in parent–child dyads can inform future research and interventions. We tested a partial least squares path model based on the integrated behavior change model in insufficiently active Finnish parent–child dyads (n = 88), including measures of autonomous and controlled motivation, social cognition constructs (attitude, subjective norm, perceived behavioral control), intention, planning, and habits. Autonomous motivation predicted attitude in both samples, but only predicted subjective norms and perceived behavioral control in children. Attitude in turn predicted intention, planning, and habit, in the child sample, but only intention and planning in parents. Perceived behavioral control predicted intention and planning only in children, while subjective norm had minimal effects in either sample. Autonomous motivation and attitude consistently determined intention and planning for both parents and children, highlighting their importance in future research and interventions.
Impacts of the Accreditation Process for Undergraduate Medical Schools: A Scoping Review
Authors: Girotto Leticia C. , Machado Karynne B. , Moreira Roberta F. C. , Martins Milton A. , Tempski Patrícia Z. 
Published: February 2025

ABSTRACTObjectiveThe objective of this study is to identify, synthesize and communicate research findings; identify research gaps; and formulate recommendations for future research regarding the impact of the accreditation process on undergraduate medical schools around the world.MethodThis scoping review followed the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses–extension for scoping reviews (PRISMA‐ScR). The electronic search was performed up to March 2024 to identify studies that investigated the impact of the accreditation process on undergraduate medical schools. Two independent reviewers performed the selection process and extracted data from the included studies to perform a qualitative analysis.ResultsThe search identified 5148 references. After the selection process, 31 studies from 14 countries were included for data extraction. Studies highlighted five main themes: curricular and governance changes, continuous quality improvement, students' performance, school recognition and student satisfaction, and accreditation data sharing proposal. Three studies presented negative points related to accreditation process.ConclusionThe accreditation process induced both positive impacts and negative burdens for undergraduate medical schools. Continuous quality improvement is a common element identified by studies to help stakeholders ensure that accreditation improves the quality of medical education and, consequently, the health care provided. Experiences with accreditation should be shared and reported to improve the quality of medical education worldwide. Future studies must be carried out with a clear description of the domains and criteria considered during the accreditation process as well as the outcome measures used.
Tenoscopic‐guided resection of the manica flexoria utilizing radiofrequency energy. A proof of concept study
Authors: Barton Charlotte K. , Nelson Brad B. , Winther Taylor M. , Maker Tristan C. , Goodrich Laurie R. 
Published: February 2025

AbstractObjectiveTo develop and optimize a tenoscopic technique for resection of the manica flexoria utilizing a radiofrequency probe.Study designExperimental study.AnimalsEighteen cadaver limbs and two experimental horses.MethodsTenoscopic‐guided resection of the manica flexoria using radiofrequency energy proceeded sequentially by transection of the medial, lateral and proximal borders. The technique was performed in ex vivo limbs and then in vivo to replicate clinical scenarios. Time to complete resection of the manica flexoria (mean ± SD) and complications was recorded. Limbs were dissected and scored for features of transection and collateral injury on a 15‐point scale (15 was optimal). Tenocyte viability and histology were performed on tissues from the in vivo procedures.ResultsTransection of the manica flexoria was achieved in all limbs (18/18 ex vivo and 8/8 in vivo). Surgery time was 30.6 ± 12.7 minutes (ex vivo) and 26.1 ± 7.5 minutes (in vivo). Limb scores representing iatrogenic damage and resection borders revealed an average ex vivo score of 14.3 ± 0.67 and live horse score of 14.8 ± 0.43. Histology and live/dead staining did not identify changes in tissue architecture and revealed minimal cell death following radiofrequency exposure.ConclusionThe described technique, utilizing radiofrequency energy, is a successful approach for safe transection of the manica flexoria. The procedure allowed for complete symmetric resection of the manica flexoria with minimal iatrogenic damage to surrounding tissues.Clinical significanceResection of a torn manica flexoria may be technically challenging and utilization of sharp instrumentation risks accidental iatrogenic damage. Resection using radiofrequency represents a feasible alternative technique.
A randomised, double‐blind, placebo‐controlled study to determine the analgesic efficacy, safety and tolerability of VPX638 administered topically to painful wounds
Authors: Golledge Jonathan , Parra Sergio , Aldons Pat M. , Frescos Nicoletta , Iseli Rebecca K. , Pardey Toni M. , Pretorius Casper F. , Shum Omar R. , Yates Paul A. , Bascoul Cécile B. , Doolittle Dannette K. , Rege Ajay A. , Thanawala Vaidehi J. , Giles Heather , Woodward Michael C. 
Published: February 2025

AbstractNew analgesics are needed for painful wounds. Multiple reports suggest that topical sevoflurane may have analgesic effects. This placebo‐controlled randomised trial evaluated the analgesic efficacy and safety of VPX638 (topical sevoflurane). Seventy‐eight participants with painful wounds, were enrolled at eight Australian centres and randomly allocated to receive 2 × 5 mL of VPX638 (N = 39) or placebo (N = 40) during one wound dressing change. Numerical pain rating scores and use of opioids were recorded for 24 h. The primary endpoint was pain during wound cleaning, secondary endpoints evaluated pain for 24 h after drug application and opioids use. There was no significant difference in mean pain scores during wound cleaning between VPX638 and placebo (0.854; p = 0.23). The mean differences in summed pain intensity difference from baseline suggested VPX638 provided greater analgesia compared to placebo over 8 h (p < 0.02), 12 h (p < 0.01) and 24 h (p < 0.05) and significantly longer duration of analgesia, 24.3 h for VPX638 versus 7.1 h for placebo (p < 0.01). In the 24 h after drug administration, participants receiving VPX638 had a 50% decrease in opioid use over 24 h compared with placebo. VPX638 appeared safe and well‐tolerated. In conclusion, this small placebo‐controlled randomised trial suggested that VPX638 provides analgesia and is opioid‐sparing for up to 24 h after wound cleaning. It supports the need for further evaluation of the benefit of VPX638 as a topical analgesic for painful wounds.
Sport and the Promise of Artificial Intelligence: Human and Machine Futures
Authors: Millington Brad , Naraine Michael L. , Wanless Liz , Safai Parissa , Manley Andrew 
Published: February 2025

Artificial intelligence (AI) has the capacity to deliver generative, complex, and powerful functions and decisions. Sport offers a unique site for AI development and implementation, yet the sociological significance of AI in sport remains understudied. We consider sport-based AI applications en route to describing the promise of AI in sport in four ways: (a) the promise of supercharged data parsing at scale, (b) the promise of supercharged precision, (c) the promise of supercharged personalization; and (d) the promise of supercharged prediction. We argue in turn that AI is an emergent cultural form in sport that foregrounds labor automation as a pathway to efficiency but also brings potential for substantial disruption. We further contend that sport is a use case for AI at a moment when the legitimacy of AI is intensely debated.
MEGA: A computational framework to simulate the Acute Respiratory Distress Syndrome
Authors: Bruna-Rosso Claire , Boussen Salah 
Published: February 2025

The Acute Respiratory Distress Syndrome (ARDS) is a critical condition that necessitates mechanical ventilation (MV) to ensure sufficient ventilation and oxygenation for patients. Intensivists employ various therapeutic tools such as adjusting Positive End Expiratory Pressure (PEEP) levels or positioning the patient prone. However, practitioners encounter several challenges when dealing with ARDS: High variability among patients, Limited understanding of underlying mechanisms As a result, decision-making by physicians largely relies on experience. Yet, having the ability to estimate the likelihood of a patient responding to different therapeutic approaches would hold significant clinical value. Moreover, gaining a deeper understanding of the biomechanical and physiological phenomena underlying patient responses could inform the development of new MV strategies for ARDS management. To address these challenges, a coupled physio-mechanical computational framework based on patient CT-scan data was conceived and implemented. Simulations were conducted for prone positioning and PEEP-increment scenarios. The model results qualitatively align with both literature data and clinical measurements. However, some results diverge quantitatively from clinical measurements, emphasizing the necessity for thorough model calibration. Nonetheless, this serves as a proof of concept that the developed framework could be valuable in supporting intensivists' decision-making processes.
Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small Molecule Reactivator
Authors: Puzio-Kuter Anna M. , Xu Lizhong , McBrayer Mary Kate , Dominique Romyr , Li Hongju H. , Fahr Bruce J. , Brown Alyssa M. , Wiebesiek Amy E. , Russo Brandon M. , Mulligan Chris L. , Yang Hong , Battaglia Josh , Robell Kimberly A. , Thomas Dafydd H. , Huang Kuo-Sen , Solovyov Alexander , Greenbaum Benjamin D. , Oliner Jonathan D. , Davis Thomas W. , Dumble Melissa L. , Johnson Melissa L. , Xiong Shunbin , Yang Peirong , Lozano Guillermina , Fellous Marc M. , Vu Binh T. , Schram Alison M. , Levine Arnold J. , Poyurovsky Masha V. 
Published: February 2025

Abstract
Restoration of the tumor suppressor function of tumor-associated p53 mutants, including the Y220C substitution, has posed a significant challenge for therapeutic discovery. Here, we describe rezatapopt (PC14586), part of a series of compounds designed to reactivate the p53 Y220C mutant. These compounds restore p53 tumor suppressor function by correcting its conformation and enabling it to bind DNA and activate downstream target genes, thus inducing anti-proliferative changes in tumor cells. Our findings are supported by biochemical and structural analysis, in vitro and in vivo transcriptomics, and functional data, revealing the recovery of multiple aspects of the wild type p53 program. These compounds demonstrate potent anti-tumor activity in preclinical models as single agents and in combination with immunotherapy. Currently, rezatapopt is being evaluated in a registrational Phase 2 clinical trial for patients with advanced solid tumors harboring the TP53 Y220C mutation.
Memory Objects, Homemaking and Translation as Affective Labour in Fadia Faqir’s My Name Is Salma
Authors: Alhussein Akkad 
Published: February 2025

Abstract
This article analyses memory and nostalgia objects in Fadia Faqir’s novel My Name Is Salma as a form of embodied remembering and cultural translation in everyday material life. Through the protagonist’s transcultural experiences and daily encounters, the novel draws attention to the creative uses of migrant nostalgia in diasporic space as a means of negotiating the intricacies of body, memory, home and identity. Migrant homebuilding and cultural translation through objects are examined as performative and embodied memory. This, I argue, becomes in the uprooting of migration a valuable strategy that connects the migrant with lost homely geographies and allows translation between past and present. Reading the novel through this lens also shows that homely objects and rituals related to food and other nostalgic attachments from home are embedded in discourses of power, race and gender and informed by experiences of trauma and hegemony.