bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Palladium‐Catalyzed Intramolecular Decarboxylative Coupling of Arene Carboxylic Acids/Esters with Aryl Bromides.
Authors: Shen Zengming , Ni Zhenjie , Mo Song , Wang Jing , Zhu Yamin 
Published: August 2012

AbstractThe title method gives access to benzo[c]chromenes, dibenzofurans, phenanthridines, carbazoles, and tetracyclic fused pyrrole derivatives.
ChemInform Abstract: Selective Iron‐Catalyzed Transfer Hydrogenation of Terminal Alkynes.
Authors: Wienhoefer Gerrit , Westerhaus Felix A. , Jagadeesh Rajenahally V. , Junge Kathrin , Junge Henrik , Beller Matthias 
Published: August 2012

AbstractA novel Fe‐catalyzed transfer hydrogenation of alkynes to corresponding alkenes using formic acid as hydrogen donor is developed.
ChemInform Abstract: Development of a Palladium on Boron Nitride Catalyst and Its Application to the Semihydrogenation of Alkynes.
Authors: Yabe Yuki , Yamada Tsuyoshi , Nagata Saori , Sawama Yoshinari , Monguchi Yasumari , Sajiki Hironao 
Published: August 2012

AbstractThe chemoselective hydrogenation of terminal and internal alkynes towards alkenes proceeds smoothly in the presence of di(aminoethyl)amine (DETA) and Pd on boron nitride as catalyst.
ChemInform Abstract: Highly anti‐Selective One‐Pot Multicomponent Synthesis of Mannich‐Type N‐Acylated β‐Amino Acid Derivatives by Copper or Sodium Salt Catalysis.
Authors: Bahulayan D. , Shinu V. S. , Pramitha P. , Arun S. , Sheeja B. 
Published: August 2012

Abstract23 Title compounds of type (IV), (VIII) and (XII) are prepared by a one‐pot three‐component reaction of enolizable ketones with nitriles and aromatic aldehydes.
ChemInform Abstract: Copper‐Catalyzed N‐Alkylation of Amides and Amines with Alcohols Employing the Aerobic Relay Race Methodology.
Authors: Li Qiang , Fan Songjian , Sun Qing , Tian Haiwen , Yu Xiaochun , Xu Qing 
Published: August 2012

AbstractA greener and more advantageous method for the title reaction is developed.
ChemInform Abstract: Synthesis of Sulfondiimines by N‐Chlorosuccinimide‐Mediated Oxidative Imination of Sulfiliminium Salts.
Authors: Candy Mathieu , Guyon Carole , Mersmann Stefanie , Chen Jia‐Rong , Bolm Carsten 
Published: August 2012

AbstractThe reaction of compound (Ia) is carried out on a multigram scale.
ChemInform Abstract: Atropoisomeric (P,N) Ligands for the Highly Enantioselective Pd‐Catalyzed Intramolecular Asymmetric α‐Arylation of α‐Branched Aldehydes.
Authors: Nareddy Pradeep , Mantilli Luca , Guenee Laure , Mazet Clement 
Published: August 2012

AbstractThe shown ligand is successfully applied to the title reaction.
ChemInform Abstract: A Novel Synthesis of Multisubstituted Pyrroles via Trisubstituted Olefins and TosMIC Derivatives.
Authors: Qiu Fangli , Wu Jianwei , Zhang Yaohong , Hu Miao , Yu Feng , Zhang Guolin , Yu Yongping 
Published: August 2012

AbstractA simple and effective protocol for the synthesis of multi‐substituted pyrroles under mild conditions in good to excellent yields is reported.
ChemInform Abstract: One‐Pot Four‐Component Domino Reaction for the Synthesis of Substituted Dihydro‐2‐oxypyrrole Catalyzed by Molecular Iodine.
Authors: Khan Abu T. , Ghosh Arindam , Khan Md. Musawwer 
Published: August 2012

AbstractThe pyrrole derivatives include a β‐amino acid part and are thus of importance for pharmaceutical investigations.
ChemInform Abstract: One‐Pot Synthesis of Isoindolinones via Three‐Component Mannich/Lactamization Cascade Reaction.
Authors: Zhang Haoyi , Leng Yixin , Liu Wenjing , Duan Wenhu 
Published: August 2012

AbstractIsoindolinones of type (IV), (VI), (VIII) or (X)/(XI) are prepared by a three‐component Mannich/lactamization cascade reaction of o‐formylbenzoates with enolizable ketones and amines.
ChemInform Abstract: Polystyrene‐Bound Diethanolamine Based Ionic Liquids for Chemical Fixation of CO2.
Authors: Chen Xi , Sun Jian , Wang Jinquan , Cheng Weiguo 
Published: August 2012

AbstractPEA exhibits the highest activity and selectivity in the conversion of epoxides and aziridines into the corresponding cyclic carbonates and oxazolidonines, respectively.
ChemInform Abstract: Synthesis and Antimicrobial Activities of New 4,6‐Diaryl‐4,5‐dihydro‐3‐hydroxy‐2H‐indazoles.
Authors: Amutha Parasuraman , Nagarajan Samuthira 
Published: August 2012

AbstractCyclization of substituted ethyl cyclohexenonecarboxylates (I) with hydrazine hydrate provides access to target indazoles (II).
ChemInform Abstract: An Atom‐Economical Approach to the Synthesis of Potentially Bioactive 2H‐Chromenes via CuI‐Catalyzed Reactions of Alkyl/Aryl‐(E)‐(o‐Propargyloxy)styryl Ketones.
Authors: Majumdar K. C. , Ansary Inul , Shyam Pranab K. , Roy B. 
Published: August 2012

AbstractProduct (IId) is known to possess in vitro antileishmanial activity at noncyctotoxic concentrations.
ChemInform Abstract: Preparation of 2‐, 4‐, 5‐, and 6‐Aminonicotinic Acid tert‐Butyl Esters.
Authors: Wright Stephen W. 
Published: August 2012

AbstractAn improved three‐step procedure is developed to prepare the title esters, e.g. (V), performing the esterification before hydrazine formation, and without the need for purification of the intermediates.
ChemInform Abstract: Aryl Grignard Reagents in Chemodivergent N‐ and C‐Arylations: Concise Access to Two Families of Tetracyclic Fused Carbazoles from 6‐Nitroquinolines.
Authors: Sanchez Juan Domingo , Egris Riccardo , Perumal Subbu , Villacampa Mercedes , Menendez J. Carlos 
Published: August 2012

AbstractQuinolines (I) and (XI) react in a chemodivergent mode with the Grignard compounds.
ChemInform Abstract: Tandem‐Type Pd(II)‐Catalyzed Oxidative Heck Reaction/Intramolecular C—H Amidation Sequence: A Novel Route to 4‐Aryl‐2‐quinolinones.
Authors: Inamoto Kiyofumi , Kawasaki Junpei , Hiroya Kou , Kondo Yoshinori , Doi Takayuki 
Published: August 2012

AbstractA novel catalytic method for the synthesis of 4‐aryl‐2‐quinolines (III) and (V)/(VI) is reported.
ChemInform Abstract: P2O5 Promoted One‐Pot Synthesis of 3‐Aminoimidazo[1,2‐a]pyridines under Solvent‐Free Conditions.
Authors: Soleimani Ebrahim , Taran Mojtaba , Zainali Mohsen , Lotfi Shahram 
Published: August 2012

AbstractPhosphorus pentoxide is found to be a highly efficient biodegradable catalyst for the three‐component reaction of 2‐aminopyridines (I) with aromatic aldehydes (III) and isocyanides (II) under solvent‐free conditions.
ChemInform Abstract: Synthesis and Antimicrobial Activity of Some Condensed [4‐(2,4,6‐Trimethylphenyl)‐1(2H)‐oxo‐phthalazin‐2‐yl]acetic Acid Hydrazide.
Authors: El‐Hashash Maher A. , El‐Kady Ahmed Y. , Taha Mamdouh A. , El‐Shamy Ibrahim E. 
Published: August 2012

AbstractCompounds (VI), (IX), (XIc) and (XId) exhibit good activity against S.
ChemInform Abstract: Optimized Liebeskind—Srogl Coupling Reaction Between Dihydropyrimidines and Tributyltin Compounds.
Authors: Sun Qi , Suzenet Franck , Guillaumet Gerald 
Published: August 2012

AbstractDihydropyrimidothione substrates are successfully coupled with tributyltins to produce potentially biologically active dihydropyrimidines.
ChemInform Abstract: Facile Synthesis of 5‐Aryl‐1‐[(arylamino)methyl]‐1,3,5‐triazinane‐2‐thiones.
Authors: Zhang Zhenfeng , Wang Siqian , Zhang Guisheng 
Published: August 2012

AbstractAcid‐catalyzed cyclocondensation of thiourea (I) with aromatic amines (II) and formaldehyde (III) in a one‐step procedure allows for rapid synthesis of title compounds (IV) in good yield.
ChemInform Abstract: A Cascade Reaction of Pyrrole‐2‐carbaldehyde Substituted Morita—Baylis—Hillman Adducts in the Presence of Tetrabutylammonium Hydroxide or Acetate to Construct Aza‐Heterocycles.
Authors: Huang Long , Shi Min 
Published: August 2012

AbstractA phase‐transfer catalyst promoted intramolecular transformation of pyrrole‐2‐carbaldehyde substituted Morita—Baylis—Hillman adducts as an efficient way to construct pyrrolo[1,2‐a]azepin‐7(6H)‐one skeletons in moderate to good yields is presented.
ChemInform Abstract: Synthesis, Photophysical Properties and Near Infrared Electroluminescence of 1(4),8(11),15(18),22(25)‐Tetra‐(methoxy‐phenoxy)phthalocyanine.
Authors: Bai Qinglong , Zhang Chunhua , Cheng Chuanhui , Li Wancheng , Wang Jin , Du Guotong 
Published: August 2012

AbstractRoom‐temperature NIR‐EL is found to be near 891 nm that effectively covers the first optical communication window near 850 nm.
ChemInform Abstract: Synthesis of (2S,4S)‐4‐Hydroxyproline from D‐Glucose.
Authors: Mereyala Hari Babu , Pathuri Gopal , Nagarapu Lingaiah 
Published: August 2012

AbstractTitle compound (V) is prepared in 3.5% overall yield from diacetone‐D‐glucose (I) employing catalytic hydrogenation of compound (II) leading to bicyclic oxazo compound (III) as the key step.
ChemInform Abstract: Organotin‐Catalyzed Highly Regioselective Thiocarbonylation of Nonprotected Carbohydrates and Synthesis of Deoxy Carbohydrates in a Minimum Number of Steps.
Authors: Muramatsu Wataru , Tanigawa Satoko , Takemoto Yuki , Yoshimatsu Hirofumi , Onomura Osamu 
Published: August 2012

AbstractThe thiocarbonylation reactions are performed with a variety of unprotected pyranosides and O‐aryl chlorothioformates to give monothiocarbonates in a highly regioselective manner.
ChemInform Abstract: Synthesis of Procyanidin B1 (IVb), B2 (IVa), and B4 (V) and Their Antiinflammatory Activity: The Effect of 4‐Alkoxy Group of Catechin and/or Epicatechin Electrophiles for Condensation.
Authors: Katoh Miyuki , Oizumi Yukiko , Mohri Yoshihiro , Hirota Mitsuru , Makabe Hidefumi 
Published: August 2012

AbstractThe antiinflammatory effects of the three title compounds on TPA‐induced inflammation of mouse ears are higher than those of indomethacin or glycyrrhetinic acid.
ChemInform Abstract: New Method of Synthesis and Biological Evaluation of Some Combretastatin A‐4 Analogues.
Authors: Malysheva Yulia B. , Combes Sebastien , Fedorov Alexey Yu. , Knochel Paul , Gavryushin Andrei E. 
Published: August 2012

AbstractThirteen novel analogues are prepared by Negishi cross‐coupling of iodide (III) and aryl halides.
ChemInform Abstract: Anisotropy of Spin Relaxation and Transverse Transport in Metals
Authors: Mokrousov Yuriy , Zhang Hongbin , Freimuth Frank , Zimmermann Bernd , Long Nguyen H. , Weischenberg Juergen , Souza Ivo , Mavropoulos Phivos , Bluegel Stefan 
Published: August 2012

AbstractReview: 91 refs.
Prognostic Significance of Applying the European Society of Cardiology Consensus Algorithm for Heart Failure With Preserved Systolic Function Diagnosis
Authors: Almeida Pedro , Rodrigues João , Lourenço Patricia , Julia Maciel Maria , Bettencourt Paulo 
Published: August 2012

AbstractBackground:The diagnosis of heart failure with preserved left ventricular ejection fraction (HFpEF) is challenging. Although diagnostic criteria have been proposed, limited information exists concerning its implication on prognosis. We aimed to evaluate the prognostic significance of applying the European Society of Cardiology algorithm for HFpEF diagnosis, namely the tissue Doppler imaging information, in patients with acute heart failure (HF).Hypothesis:The application of the European Society of Cardiology algorithm for HFpEF diagnosis, identifies a group of HF patients with high morbidity and mortality.Methods:Consecutive patients admitted due to acute HF were recruited. The European Society of Cardiology algorithm was used in the HFpEF diagnosis. Patients were followed for a 6‐month period and mortality and rehospitalization due to HF were recorded.Results:A total of 491 patients were included in this registry. Mean patient age was 78 years and 63% were women; 177 patients had HFpEF and 314 had HF with reduced ejection fraction (HFrEF). Of the HFpEF patients, 44.8% had an E/E′ ratio >15 and 1.8% had an E/E′ ratio <8. Patients with HFpEF and those with HFrEF had a similarly dismal prognosis when considering all‐cause mortality, and morbidity and mortality, but there was a trend for better survival when HF death was the outcome in analysis (hazard ratio 1.63 [95% confidence interval: 0.95–2.80, P = 0.08]).Conclusions:The use of objective criteria for diagnosis of HFpEF identifies patients with similar outcomes as patients with HFrEF; this observation increases the robustness of the diagnostic criteria for HFpEF. The use of objective criteria for the diagnosis of HFpEF identifies patients with a similarly ominous prognosis as patients with HFrEF; this observation increases the robustness of the diagnostic criteria for HFpEF. Identifying these patients based on objective criteria, as we did, is an important step for future investigation, namely drugs, warranted to the HFpEF approach.This work was performed at the departments of internal medicine and cardiology at Centro Hospitalar São João in Porto, Portugal. This work was supported by a grant from Fundação para a Ciência e a Tecnologia (Foundation for Science and Technology), project PIC/IC/82773/2007.The authors have no other funding, financial relationships, or conflicts of interest to disclose.
C‐Reactive Protein Level and the Incidence of Eligibility for Statin Therapy: The Multi‐Ethnic Study of Atherosclerosis
Authors: Mann Devin M. , Shimbo Daichi , Cushman Mary , Lakoski Susan , Greenland Philip , Blumenthal Roger S. , Michos Erin D. , Lloyd‐Jones Donald M. , Muntner Paul 
Published: August 2012

AbstractBackground:Given the results of the Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) trial, statin initiation may be considered for individuals with elevated high‐sensitivity C‐reactive protein (hsCRP). However, if followed prospectively, many individuals with elevated CRP may become statin eligible, limiting the impact of elevated CRP as a treatment indication. This analysis estimates the proportion of people with elevated CRP that become statin eligible over time.Hypothesis:Most people with elevated CRP become statin eligible over a short period of time.Methods:We followed 2153 Multi‐Ethnic Study of Atherosclerosis (MESA) participants free of cardiovascular disease and diabetes with low‐density lipoprotein cholesterol <130 mg/dL at baseline to determine the proportion who become eligible for statins over 4.5 years. The proportion eligible for statin therapy, defined by the National Cholesterol Education Program (NCEP) 2004 updated guidelines, was calculated at baseline and during follow‐up stratified by baseline CRP level (≥2 mg/L).Results:At baseline, 47% of the 2153 participants had elevated CRP. Among participants with elevated CRP, 29% met NCEP criteria for statins, compared with 28% without elevated CRP at baseline. By 1.5 years later, 26% and 22% (P = 0.09) of those with and without elevated CRP at baseline reached NCEP low‐density lipoprotein cholesterol criteria and/or had started statins, respectively. These increased to 42% and 39% (P = 0.24) at 3 years and 59% and 52% (P = 0.01) at 4.5 years following baseline.Conclusions:A substantial proportion of those with elevated CRP did not achieve NCEP‐based statin eligibility over 4.5 years of follow‐up. These findings suggest that many patients with elevated CRP may not receive the benefits of statins if CRP is not incorporated into the NCEP screening strategy.Additional Supporting Information may be found in the online version of this article.The Multi‐Ethnic Study of Atherosclerosis (MESA) was supported by contracts NO1‐HC‐95159 through NO1‐HC‐95165 and NO1‐HC‐95169 from the National Heart, Lung, and Blood Institute. This research was also supported by grant 1K23DK081665, a Patient‐Oriented Mentored Scientist Award through the National Institute of Diabetes, Digestive, and Kidney Diseases (to DMM). The authors have no other funding, financial relationships, or conflicts of interest to disclose.
Performance Evaluation of a Full‐Scale Extended Aeration System in Al‐Bireh City, Palestine
Authors: Al‐Sa'ed Rashed , Tomaleh Nayef 
Published: August 2012

AbstractMajor challenges attributed to dysfunctional wastewater treatment facilities in developing countries include lack of commitment and poor informed decision making by the higher municipal administration. This paper presents how process monitoring and control during full scale operation ensures sustainability of civic infrastructures like Al‐Bireh wastewater treatment plant (AWWTP). It is written from the perspective of practical process selection to evaluate the performance of AWWTP, a single‐sludge nitrification–denitrification process with aerobic sludge stabilization. Process monitoring data (July 2000–April 2007) from available monthly operating reports were analyzed and evaluated. Additional data on microbiological analysis and information about facility unit operations were gathered through review of published local literature and interviews with AWWTP personnel. Influent and effluent data evaluated were the chemical oxygen demand (COD), biological oxygen demand (BOD), total nitrogen (TN), and total phosphorus (TP). Despite annual and seasonal variations in AWWTP influent for COD, BOD, TN, and TP, the Palestinian wastewater reuse requirements for restricted irrigation were met. Process design and proper facility operation have direct impacts on effluent quality. The study concludes that regardless of the design capacity and process type, adequate administrative and operational management dictate the sustainability of AWWTP and reuse schemes.
Effect of Sample Digestion, Air Filter Contamination, and Post‐adsorption on the Analysis of Trace Elements in Air Particulate Matter
Authors: Yang Xiao Jin , Wan Pingyu , Foley Roy 
Published: August 2012

AbstractInductively coupled plasma atomic emission spectrometry and inductively coupled plasma MS are the major analytical tools for trace elements in environmental matrices, however, the underestimate of certain trace elements in analysis of air particulate matter by these two techniques has long been observed. This has been attributed to incomplete sample digestion. Here, we demonstrate that the combined effects of sample digestion, air filter impurities, and post‐adsorption of the analytes contribute to the interference of the analysis. Particular attention should be paid to post‐adsorption of analytes onto air filters after acid digestion.
Detoxification of Arsenite through Adsorption and Oxidative Transformation on Pyrolusite
Authors: Liu Chengshuai , Wang Xiangqing , Li Xiujuan , Cao Weidong , Yang Jinyan 
Published: August 2012

AbstractAdsorption and oxidative transformation processes critically affect the mobility and toxicity of arsenic (As) in the environment. In this study, the detoxification of arsenite through adsorption and oxidation by pyrolusite was systematically investigated. Disappearance of aqueous As(III) in the solution can be efficiently achieved using pyrolusite. The As(III) oxidative transformation product arsenate or As(V) was obtained both in the solution and on the pyrolusite surface. The arsenic species adsorbed on pyrolusite exist in two forms: As(III) and As(V). Furthermore, over 64.8% of the adsorbed As cannot be desorbed. They were fixed more stably in the structure of the mineral to achieve a safer removal. Lower As(III) initial concentration increased As(III) detoxification rates. Elevating the reaction pH from 4.5 to 7.9 elicited a slight effect on the disappearance rate of As(III). Efficient As(III) detoxification can be achieved by pryrolusite within the studied pH range. The addition of low‐molecular‐weight carboxylic acids decreased the detoxification rate of As(III) through competition for active sites on pyrolusite. Co‐existing divalent metal ions, such as Ca2+, Ni2+, and Mn2+, also decreased the detoxification rate of As(III). However, the trivalent ion Cr3+ largely increased the detoxification rate through co‐precipitation and adsorption processes.
Heterolytic Alkyl Hydroperoxide O–O Bond Cleavage by Copper(I) Complexes
Authors: Tano Tetsuro , Sugimoto Hideki , Fujieda Nobutaka , Itoh Shinobu 
Published: August 2012

AbstractThe reaction of copper(I) complexes and cumene hydroperoxides was examined to demonstrate that heterolytic O–O bond cleavage of the peroxides proceeds predominantly to give the corresponding alcohols (cumyl alcohols) as the major product, when the stoichiometry of CuI/peroxide is 2:1. The result is in sharp contrast to the 1:1 reaction between the copper(II) complexes and cumene hydroperoxide, which provides the ketone (acetophenone) as the major product through homolytic O–O bond cleavage.
Amination of Aryl Halides by Using an Environmentally Benign, Recyclable Copper Catalyst
Authors: Huang Manna , Wang Leilei , Zhu Xinhai , Mao Zuxing , Kuang Daizhi , Wan Yiqian 
Published: August 2012

AbstractThe combination of CuSO4 with naturally occurring sucrose in a biodegradable aqueous solution of PEG‐200 has been confirmed as a novel, recyclable, and environmentally benign homogeneous catalyst system for the direct amination of aryl halides with NH3·H2O. Electron‐rich, electron‐poor, and even ortho‐substituted aryl bromides and iodides could be aminated to provide the desired primary arylamines in high yields at 90 °C without the need of an inert atmosphere.
E2F3b over‐expression in ovarian carcinomas and in BRCA1 Haploinsufficient fallopian tube epithelium
Authors: Smith Na Lu , Welcsh Piri , Press Joshua Z. , Agnew Kathy J. , Garcia Rochelle , Swisher Elizabeth M. 
Published: August 2012

AbstractWe have previously shown that the E2F3 oncogene is up‐regulated as part of a “preneoplastic expression profile” in fallopian tube epithelium (FTE) of women with BRCA1 mutations. We studied E2F3 expression in FTE and carcinomas of women with BRCA1 or BRCA2 mutations or wildtype for both genes. Significantly more foci of TP53 positive cells in histologically normal FTE from women with BRCA1 mutations but not in wildtype or BRCA2 mutated individuals had E2F3 protein overexpression relative to adjacent normal FTE, which occurred in the context of focally increased proliferation, potentially explaining the increased neoplastic potential of tubal TP53 foci in women with BRCA1 mutations. To assess mechanisms of E2F3 deregulation in ovarian or tubal carcinogenesis, we studied E2F3 and its two isoforms E2F3a and E2F3b in wild‐type ovarian carcinomas and ovarian carcinomas associated with germline BRCA1 and BRCA2 mutations. The expression of E2F3b, but not E2F3a, was correlated with the expression of BRCA1 in all three genetic groups. In primary cultures of FTE from women with BRCA1 mutation or wildtype for BRCA1 and BRCA2, siRNA‐induced BRCA1 deficiency led to increased E2F3b but not E2F3a expression. Our results suggest that E2F3b and BRCA1 are functionally connected, and BRCA1 haploinsufficiency in normal FTE may lead to up‐regulation of E2F3b and increased proliferation before the development of intraepithelial neoplasia. These data support that E2F3b up‐regulation is an important preneoplastic event in FTE from BRCA1 mutation carriers. © 2012 Wiley Periodicals, Inc.