bluuebunny/crossref_metadata_2025_split huggingface dataset:
575-P: Nigerian Patients with Noncommunicable Diseases Have Suboptimal Baseline Self-Efficacy Scores to Manage Chronic Diseases
Authors: EZENWAKA CHIDUM E. , TRIPARTITE RESEARCH COLLABORATION CONSORTIUM (TTRCC) THE 
Published: June 2024

Introduction & Objective: Nigeria is one of the developing countries with a major burden of non-communicable diseases (NCDs) without disease self-management programme in its healthcare system. This study aimed to determine the baseline self-efficacy levels of Nigerian patients with chronic NCDs.
Methods: This is a cross-sectional study of patients with NCDs attending tertiary level clinics with full compliments of NCD healthcare professionals. Patients were interviewed on ten-Self-Efficacy questionnaires to Manage Chronic Disease (SEMCD) item scales that were appropriate for the Nigerian population. The patients were assessed under: (i) exercise regularly, (ii) help from community, family and friends, (iii) communication with physician, (iv) manage disease and (v) manage symptom self-efficacy domains. Data were analysed both descriptively and statistically using the SPSS software.
Results: The results showed that more females (59.4%) than males (40.6%) attended clinics during the 3 months study period, and the mean age of the patients did not differ between gender (p&gt;0.05). About 40% of all the patients manage their NCDs with medications alone, a trend that is similar in male and female patients (p&gt;0.05). While all the patients had a relatively lower self-efficacy scores under regular exercise scale (52-55%) and manage disease symptoms scale (53-55%), they tended towards higher self-efficacy scores under getting assistance from community, family, and friends (79-80%) and communication with attending physicians (81-85%).
Conclusion: Nigeria patients with NCDs at tertiary level institution clinics are less than optimal in disease self-management care. The observed sub-optimal self-efficacy levels might be a contributing factor to high premature NCD deaths in this population. It is recommended that this study population will benefit from introduction and implementation of disease self-management programme in the healthcare system.

Disclosure
C.E. Ezenwaka: None.
578-P: School-Partnered Type 1 Diabetes (T1D) Interventions—A Path to Successful Implementation
Authors: MARCH CHRISTINE , NAAME ELISSA , ALFINITO SOPHIA , RANKINE JACQUELIN , SIMINERIO LINDA M. , KAZMERSKI TRACI M. , ALBANESE-O'NEILL ANASTASIA , LYON AARON , MILLER ELIZABETH , LIBMAN INGRID 
Published: June 2024

School-partnered interventions with clinical diabetes centers may help optimize child T1D health outcomes. Such interventions are under-studied and published examples are short-term with mixed benefit. We aimed to discover factors affecting implementation of T1D interventions in school to better design future programs. We conducted semi-structured interviews with school nurses (SN) in Pennsylvania (n=20) and West Virginia (n=10). Transcripts were coded by two reviewers using a consensus-driven approach. Major themes were aligned with an implementation science framework. SN represented various geographic settings (52% rural, 41% suburban, 7% urban) and years of experience (24% &lt;5, 21% 5-10, 28% 11-20, 27% &gt;20 years). SN from both states perceived factors to influence implementation of T1D interventions in school related to four themes. Theme 1 Motivating Factors: T1D interventions are prioritized as these students have complex medical needs and there is a dearth of available resources for school staff. Theme 2 Facilitators: Schools have existing structures which could support T1D interventions, including procedures to assemble multidisciplinary teams and expanded use of video conferencing since the pandemic. Theme 3 Challenges: Variable parent engagement and limited school health staffing may interfere with schools’ ability to participate in interventions. Theme 4 Peer Influence: Communication between school districts can influence adoption of interventions and should be considered when approaching school leaders. Differences in state policy for school health and insulin administration affected SN perceptions for who should lead interventions and funding for SN. Individual, school, and state-level factors will affect implementation of school-partnered T1D interventions. Understanding the unique systems for school health and working with key stakeholders may help tailor strategies to promote sustainable interventions in schools and improve T1D outcomes.

Disclosure
C. March: None. E. Naame: None. S. Alfinito: None. J. Rankine: None. L.M. Siminerio: Research Support; Becton, Dickinson and Company, Sanofi. Advisory Panel; embecta, Bayer Inc. T.M. Kazmerski: None. A. Albanese-O'Neill: None. A. Lyon: None. E. Miller: Other Relationship; Wolters Kluwer Health. I. Libman: None.

Funding
National Institutes of Health (K23DK135800)
58-PUB: Surrogate Markers of Impaired Glucose Tolerance among a Mexican-American Population without Diabetes
Authors: LABADAH JOSHUA , NARVAEZ GABRIEL , APAFLO JEHU N. , BAJPEYI SUDIP 
Published: June 2024

Impaired glucose tolerance (IGT) is defined by an elevated 2-hour plasma glucose (≥140 and &lt;200 mg/dL) during an oral glucose tolerance test (OGTT). IGT is a risk factor for diabetes development and is also classified as prediabetes according to ADA guidelines. Mexican-Americans have 1.9 times greater prevalence of diabetes compared to non-Hispanic Whites. The aim of this study was to identify blood markers associated with IGT in a predominantly Mexican-American population.
Methods: One hundred and fifty-two (77/75 male/female; 71.3% Mexican-Americans; age 26.89±10.05 years; BMI 27.39±5.90kg/m2) from border region of El Paso/Juarez participated in this cross-sectional study. Following an overnight fast, blood draw and OGTT was performed. Pearson correlation and unpaired T-test were used to analyze the data at a significance of 0.05α.
Results: White blood cell (WBC) (r=0.22, p=0.02), Neutrophil count (r=0.25, p=0.008), Platelets (r=0.27, p=0.003), Triglycerides (r=0.22, p=0.02), and Very low density lipoprotein (VLDL) (r=0.21, p=0.02) significantly correlated with 2-hour glucose. Following indices were also significantly elevated in IGT group compared to NBG: WBC [(NBG (5.25±1.76) x10^3/uL, IGT (5.89±1.38) x10^3/uL, p=0.046], Neutrophil count [NBG (2.80±1.19) x10^3/uL, IGT (3.33±1.26) x10^3/uL, p=0.044], Platelets [NBG (243.90±45.11) x10^3/uL, IGT (269.10±57.83, p=0.017], Triglycerides [NBG (91.04±50.39 mg/dL), IGT (119.20±62.99 mg/dL), p=0.017], VLDL [NBG (17.51±8.94), IGT (22.78±11.76), p=0.014].
Conclusion: Elevated WBC, neutrophil count, platelets, triglycerides and VLDL are indicative of IGT and are distinguished between individuals with NBG and IGT. Monitoring these surrogate markers during lifestyle modifications and interventions may contribute to the prevention of prediabetes and diabetes.

Disclosure
J. Labadah: None. G. Narvaez: None. J.N. Apaflo: None. S. Bajpeyi: None.
585-P: Development and Evaluation of "Diabetes Theater Café," a Café-Style Health Class Using Theater
Authors: OKAZAKI KENTARO 
Published: June 2024

Introduction & Objective: Café-style communication between medical and non-medical personnel on health has become popular. However, there are few examples of the effectiveness of health café reported. There are also few reports on health education for residents using theatrical performances. Therefore, we chose diabetes as the theme, developed and implemented a café-type health class using theatrical performances ("diabetes theater café"), and examined its effectiveness.
Methods: Pre- and post-survey; 13 participants (residents) of a diabetes theater café held at a drugstore at Osaka, Japan, in October 2022 were asked to answer an original questionnaire (5-point Likert scale) on the theme. We used paired t-tests. The diabetes theater café was developed and implemented in a multidisciplinary collaboration of physicians, pharmacists, and theater artists. A short play based on the theme was performed by professional actors at the beginning of the program. Next, participants answered the theme (dilemma) using Yes/No cards ("You were invited for a drink by a person with whom you have a delicate distance. Do you tell them you have diabetes?). Participants were then divided into groups for a time of dialogue, at the end of the session, each group decided on one theme and created and performed a 2-minute play. Throughout the program, pharmacist and physician staff added commentary on diabetes and the subject matter as appropriate.
Results: With an introductory play, Yes/No cards, and group dialogue, participants were able to conduct the theater-style presentation without difficulty. Questionnaire surveys showed a significant increase in knowledge (mean 3.6 before to 4.3 after) and confidence (mean 2.6 before to 3.1 after) in the subject matter, as well as a high level of satisfaction (mean 4.3) with the program.
Conclusion: The results suggest the usefulness of the diabetes theater café as a method of diabetes health promotion targeting local residents through multidisciplinary cooperation.

Disclosure
K. Okazaki: Speaker's Bureau; Ono Pharmaceutical Co., Ltd.

Funding
The Sugiura Memorial Foundation
587-P: Knowledge and Attitudes about Diabetes in San Antonio
Authors: GEDALA AARAV , MADAN SHREYA , VENKATESH ARUNA 
Published: June 2024

Introduction & Objective: Type 2 diabetes mellitus (T2DM) is a growing concern in San Antonio, Texas, with a prevalence rate (16%) exceeding the national average. About one in five affected individuals are unaware of their diagnosis. We aimed to assess the awareness levels of diabetes risk factors and complications within the Bexar County population.
Methods: We conducted a community-based study by administering surveys to individuals outside stores such as HEB and Walmart, as well as at a health fair where participants received complimentary health check-ups. Direct emails to complete the survey were also sent.
Results:A total of 273 individuals (Med. 42, 71% female, 44% Hispanic) completed our survey on diabetes awareness. Notably, 70.7% of respondents reported having family members with diabetes. When questioned to estimate the prevalence of diabetes or pre-diabetes in the general population over 45 years of age, 42.1% believed that 50-75% of the population had diabetes, and 44.3% estimated the figure to be between 25-50%. Approximately 81.0% perceived a higher risk of diabetes among those with a family history of the disease, but only 68.9% believed they were personally at risk. Concerning personal health practices, 80.2% of participants had previously undergone diabetes-related blood tests, and 81.3% believed in the preventability of diabetes, citing healthy eating (90.1%), regular exercise (89.1%), and weight management (71.4%) as key strategies. While a majority claimed familiarity with diabetes-related effects, 5.9% admitted a lack of awareness. Among those aware, 76.6% associated diabetes with heart disease, 76.9% with blindness, 77.3% with kidney disease, and 86.8% with limb amputation.
Conclusion: Our study, inclusive of women (70%) and minorities, revealed overestimations of diabetes prevalence. However, 80% identified family history as a risk factor, and nearly 90% recognized the importance of a healthy lifestyle. Further research should target specific demographics for public health interventions.

Disclosure
A. Gedala: None. S. Madan: None. A. Venkatesh: None.
595-P: Effect of Postprandial Sedentary Behavior Intervention on Blood Glucose Control in Patients with Type 2 Diabetes—A Randomized Controlled Trial
Authors: OSAKA TAKAFUMI , OKADA HIROSHI , FUKUI MICHIAKI 
Published: June 2024

Introduction & Objective: Physical activity is crucial for optimal blood glucose control in type 2 diabetes. This study assesses the impact of postprandial sedentary behavior on blood glucose in patients with type 2 diabetes.
Methods: Twenty-six outpatient type 2 diabetes patients participated, wearing CGM (FreeStyle Libre Pro) and an accelerometer (GT3X-BT) for a 14-day observation. Baseline dietary intake was assessed. During the initial 7 days, participants followed routine activities. In the subsequent 7 days, the sedentary(SD) group was told to "sit for at least 30 minutes after meals," and the non-sedentary(nSD) group to "avoid sitting for at least 30 minutes after meals." Random assignment was disclosed on the 7th day. Primary outcome: change in mean blood glucose (Mann-Whitney U test). Secondary outcomes: changes in mean amplitude of glycemic excursions (MAGE) and within-group comparisons before and after the intervention using paired t-tests.
Results: Analysis included 23 participants (male: 14, mean age: 74.0±4.4 years, mean HbA1c: 6.9±1.0%). No group differences in activity and diet. Change in mean blood glucose was not significant between SD (-2.9±7.3 mg/dL) and nSD groups (-4.0±6.0 mg/dL) (p=0.735). However, a significant reduction was observed in mean MAGE change between the SD group (-2.2±11.1 mg/dL) and the nSD group (-12.3±12.7 mg/dL) (p=0.023). In within-group comparisons, mean blood glucose showed changes for the SD group from 151.9±31.7 to 149.0±35.6 mg/dL (p=0.097) and for the nSD group from 148.5±25.5 to 144.5±26.9 mg/dL (p=0.024). Mean MAGE values demonstrated changes within the SD group from 81.2±19.6 to 83.4±23.3 mg/dL (p=0.750) and within the nSD group from 105.0±28.0 to 92.7±22.9 mg/dL (p=0.005).
Conclusion: The directive to "avoid sitting for at least 30 minutes after meals" is a simple, effective strategy for improving blood glucose control in diabetes.

Disclosure
T. Osaka: None. H. Okada: None. M. Fukui: None.
61-PUB: Factors Associated with Pancreatic Anti-islet Antibodies in Persons with Newly Diagnosed Diabetes Mellitus
Authors: VICH PÉREZ PILAR , TAULERO-ESCALERA BELÉN , SALINERO FORT MIGUEL A. , CONSORTIUM LADA-AP 
Published: June 2024

Introduction: Individuals initially diagnosed with diabetes mellitus (DM) may be positive for diabetes-associated autoantibodies (DAA+). The aim was to identify characteristics associated with DAA+ in a group of individuals with newly diagnosed DM, by comparing DAA+ individuals with their DAA-negative counterparts.
Methods: Cross sectional study of adults with DM. Data were collected on characteristics of 805 participants, including antibodies to glutamic acid decarboxylase (anti-GAD65), insulinoma-associated antigen IA-2 (IA-2A). Associated factors were assessed by multivariable logistic regression.
Results: Participants (56.6% male) had a median age of 61 years (IQR: 55-69) and a HbA1c of 7.0% (IQR: 6.5-8.2). DAA+ subjects were 7.2% (95% CI: 5.4-9.0). The variables strongest associated with DAA+ were age &lt;50 (OR=2.33; 95% CI: 1.05-5.18), absence of arterial hypertension (OR=2.59; 95% CI: 1.23-5.47), absence of hypercholesterolaemia (OR=2.35; 95% CI: 1.22-4.52) and no family history of type 2 DM (OR=1.95; 95% CI: 1.03-3.70). Conversely, for each 5 cm increase in waist circumference, the odds of DAA+ decrease a 17.8%.
Conclusions: The proportion of DM subjects who are DAA+ is higher than in counterpart countries. Age &lt;50 years at diagnosis, absence of arterial hypertension and hypercholesterolaemia, and absence of a family history of type 2 DM would make autoimmune DM more likely.

Disclosure
P. Vich Pérez: None. B. Taulero-Escalera: None. M.A. Salinero fort: None.

Funding
This study has been funded by Instituto de Salud Carlos III (ISCIII) through the project "PI19/01569" and co-funded by the European Union.
611-P: Effect of Continuous Glucose Monitoring (CGM) vs. Blood Glucose Monitoring (BGM) during a Nutrition Intervention on Time in Range (TIR)
Authors: WILLIS HOLLY J. , ASCHE STEPHEN E. , MCKENZIE AMY L. , ADAMS REBECCA N. , KRIZKA SHANNON , ROBERTS CAROLINE G.P. , VOLK BRITTANIE M. , ATHINARAYANAN SHAMINIE J. , ZOLLER ALISON R. , BERGENSTAL RICHARD M. 
Published: June 2024

Introduction: Reducing carbohydrate intake improves glycemia in people with T2D. Data on nutrition interventions using CGM are sparse. IGNITE (Impact of Glucose moNitoring and nutrItion on Time in rangE) compared differences in change in CGM-derived TIR (% time with glucose 70‑180 mg/dL) from baseline (Base) to three months (M3) in people using CGM or BGM during a medically supervised ketogenic diet program (MSKDP) delivered via continuous remote care.
Methods: IGNITE (NCT05516797) randomized adults with T2D to CGM (N=81) or BGM (N=82). CGM and BGM data were used by participants and the care team to support dietary adherence and medication management decisions. Blinded CGM data at Base were compared to CGM data at M3 (blinded for BGM and cloud-based for CGM).
Results: At baseline, participants were (mean + SD) 53 + 10 years; 106 + 25 kg; 10 + 8 years with T2D; taking 2.2 + 1.0 diabetes medications, and HbA1c 8.1% + 1.2%, with no differences between arms. TIR improved (Base to M3) for both arms, 28% for CGM and 23% for BGM (p&lt;0.001) with no difference in change between arms (p=0.4); the % time &lt;70 mg/dL and &lt;54 mg/dL was negligible. Reaching TIR &gt;70% and % time &lt;70 mg/dL (TBR) &lt;4% favored CGM arm. Full outcomes in Table 1.
Conclusion: TIR improved significantly for both CGM and BGM arms at M3. However, CGM users were more likely to see improvement in the combined CGM metrics of TIR &gt;70% and TBR &lt;4%.

Disclosure
H.J. Willis: Research Support; Abbott. Other Relationship; Abbott. Research Support; Academy of Nutrition and Dietetics, Dexcom, Inc. S.E. Asche: Stock/Shareholder; Gilead Sciences, Inc., AbbVie Inc., GlaxoSmithKline plc. A.L. McKenzie: Employee; Virta Health Corp. Stock/Shareholder; Virta Health Corp. Employee; Abbott. R.N. Adams: Employee; Virta Health Corp. Stock/Shareholder; Virta Health Corp. S. Krizka: None. C.G.P. Roberts: Other Relationship; Virta Health Corp. B.M. Volk: Employee; Virta Health Corp. Stock/Shareholder; Virta Health Corp. S.J. Athinarayanan: Employee; Virta Health Corp. A.R. Zoller: Employee; Virta Health Corp. Stock/Shareholder; Virta Health Corp. R.M. Bergenstal: Other Relationship; Abbott. Research Support; Arkray Marketing. Consultant; Ascensia Diabetes Care, Bigfoot Biomedical, Inc., CeQur. Other Relationship; Dexcom, Inc., Eli Lilly and Company. Consultant; embecta, Hygieia. Research Support; Insulet Corporation. Consultant; MannKind Corporation. Other Relationship; Medtronic, Novo Nordisk. Consultant; Onduo LLC, Roche Diabetes Care. Other Relationship; Sanofi. Research Support; Tandem Diabetes Care, Inc. Other Relationship; UnitedHealth Group. Consultant; Vertex Pharmaceuticals Incorporated, Zealand Pharma A/S.

Funding
Abbott Diabetes Care
613-P: Patient Characteristics Associated with Annual Nutrition Visits in Children with Type 1 Diabetes
Authors: AZOVA SVETLANA , LENNERZ BELINDA S. , PETTY CARTER , MICHELSON HANNAH , SCHMIDT ANNA , GORDON ERIN N. , GARVEY KATHARINE , RHODES ERINN 
Published: June 2024

Introduction & Objective: ADA and ISPAD recommend comprehensive nutrition education by a registered dietitian (RD) at least annually following T1D diagnosis. Study objectives were to describe longitudinal trends in annual RD follow-up in children with T1D and to identify patient characteristics associated with RD engagement.
Methods: Retrospective chart review was performed over a 5-year period (2018-2022) on patients aged &lt;18 years with T1D for ≥1 year followed at a tertiary pediatric center. Mixed effects logistic and linear regression models were conducted to assess for trends in rates of RD visit completion in the year preceding the last MD/DNE encounter and to identify sociodemographic, disease-related, and clinical patient characteristics associated with RD follow-up.
Results: Data based on 6053 completed MD/DNE visits among 1995 patients was analyzed. Annual RD follow-up rate over a 5-year period was 21%, with no differences between the years (P=0.117). Younger age, historically marginalized background, and shorter T1D duration predicted higher likelihood of RD follow-up, and RD follow-up was associated with lower hemoglobin A1c within the subsequent year (Table).
Conclusion: Annual RD visit frequency among T1D patients is suboptimal, potentially limiting opportunities for better glycemic control. Study findings provide important insights for targeted intervention to improve RD follow-up rates.

Disclosure
S. Azova: None. B.S. Lennerz: None. C. Petty: None. H. Michelson: None. A. Schmidt: None. E.N. Gordon: None. K. Garvey: Advisory Panel; Sanofi. E. Rhodes: None.

Funding
National Institutes of Health (K12DK133995)
615-P: Associations between Food Addiction and Brain Tissue Integrity in Persons with Type 2 Diabetes Mellitus
Authors: SMELTZER JOLENE T. , KUMAR RAJESH , FONG TIM W. , WOO MARY A. , CHOI SARAH E. 
Published: June 2024

Introduction & Objective: Maladaptive dietary behaviors contribute to poor glycemic outcomes for persons with type 2 diabetes (T2DM). Another factor that may contribute to poor T2DM dietary behaviors include food addiction (FA; overconsumption to the point there are similar symptoms to substance-related and addictive disorders). FA behaviors can be reflected by differences in brain tissue integrity, but the relationships between FA and brain tissue integrity in persons with T2DM are unclear. This study investigated the associations between FA and brain tissue integrity in persons with T2DM.
Methods: Twenty-one T2DM participants between the ages 40-65 years completed brain magnetic resonance imaging (MRI) scans and the Yale Food Addiction Scale 2.0 (YFAS). Using diffusion tensor imaging data, mean diffusivity (MD; a measure of brain integrity) values were calculated, and region-of-interest analyses were performed on various brain areas to examine correlations with YFAS 2.0 scores (partial correlations; covariates: age and sex).
Results: Significant correlations between tissue integrity and YFAS 2.0 scores were found in brain regions regulating executive decision-making (frontal cortices, precuneus, temporal); memory-visual or auditory (occipital, supramarginal); motor function (putamen); and emotion (cingulum) functions in T2DM patients.
Conclusions: Significant correlations appear between FA and brain tissue integrity in this population with T2DM and findings indicate that FA has a brain structural basis in persons with T2DM. Further studies are needed to understand the impact of FA on these altered brain tissue areas and to identify interventions to protect or promote neurogenesis and determine if such interventions improve T2DM outcomes.

Disclosure
J.T. Smeltzer: None. R. Kumar: None. T.W. Fong: None. M.A. Woo: None. S.E. Choi: None.

Funding
National Institutes of Health (1R01 NR017190-01)