bluuebunny/crossref_metadata_2025_split huggingface dataset:
Representations of the emotions associated with a wine purchasing or consumption experience
Authors: Mora Pierre , Moscarola Jean 
Published: May 2010

AbstractWine products possess pronounced cultural and symbolic characteristics. Given how hard it is to differentiate the product's more objective dimensions, it is important to understand the emotions and feelings that accompany wine purchasing, consuming or sharing experiences. The present study uses a writing workshop and literature review to uncover the relationships between the dimensions of the emotions that people feel during an experience of this kind, along with the mode of expression of different consumer groups. It also offers specific analysis of the role played by brands among the different characteristics of emotions. Towards this end, a series of wine‐related experiential narratives has been compiled and treated via a structural text analysis approach followed by lexical contents analysis. One of the findings breaks consumers' involvement down into four categories of emotions. Another comes from a content analysis of the narratives that will differentiate among three separate consumer groups. Lastly, suggestions will be made in terms of wider consequences for the field of wine marketing.
Expedited partner therapy for Chlamydia trachomatis at the community pharmacy
Authors: Cameron ST , Glasier A , Muir A , Scott G , Johnstone A , Quarrell H , Oroz C , McIntyre M , Miranda D , Todd G 
Published: May 2010

Please cite this paper as: Cameron S, Glasier A, Muir A, Scott G, Johnstone A, Quarrell H, Oroz C, McIntyre M, Miranda D, Todd G. Expedited partner therapy for Chlamydia trachomatis at the community pharmacy. BJOG 2010;117:1074–1079.Objective  Expedited partner treatment (EPT) for uncomplicated Chlamydia trachomatis at the pharmacy is an alternative approach to partner notification that has not yet been evaluated within the UK. The aim of this study was to evaluate EPT for partners using pharmacies in Lothian.Design  A pilot study over 18 months.Setting  Selected healthcare settings and community pharmacies in Lothian, Scotland, UK.Population  Sexual partners of index cases with uncomplicated C. trachomatis.Methods  Index cases with uncomplicated C. trachomatis were given a pharmacy voucher to pass onto sexual partners. Partners could redeem vouchers for free treatment (azithromycin) at one of 90 pharmacies in the area.Main outcome measures  The main outcome measure was the proportion of vouchers redeemed. Secondary outcomes included patient satisfaction, as determined at a telephone follow‐up of a subgroup of female index cases from one study site, 1 month later.Results  In total 577 vouchers were issued to chlamydia‐positive index patients of mean age 22.9 years (range 15–47 years). A total of 231 vouchers were redeemed (40%), at a median of 2 days after issue. Only 4% of partners attended a clinic for treatment. Most index patients surveyed reported that partners were satisfied with this method of treatment (48 out of 55; 87%).Conclusions  Expedited partner treatment for uncomplicated chlamydia at a pharmacy is a popular choice, and increases options on where, when and how partners are treated.
Smoking and pregnancy‐related pelvic pain
Authors: Biering K , Aagaard Nohr E , Olsen J , Hjollund NH , Nybo Andersen A‐M , Juhl M 
Published: May 2010

Please cite this paper as: Biering K, Aagaard Nohr E, Olsen J, Hjollund N, Nybo Andersen A‐M, Juhl M. Smoking and pregnancy‐related pelvic pain. BJOG 2010;117:1019–1026.Objective  To investigate possible associations between smoking and pregnancy‐related pelvic pain.Design  Nested case–control study.Setting  Denmark 2000–2001.Population  The Danish National Birth Cohort.Methods  The women were interviewed twice in pregnancy and twice after childbirth. The first pregnancy interview provided information on smoking and possible confounding factors, whereas the first interview after birth addressed case identification. Cases (n = 2302) were defined on the basis of self‐reported pelvic pain, and controls were selected among women who did not report pelvic pain (n = 2692). Logistic regression analysis was used to estimate associations between smoking and pelvic pain.Main outcome mreasue  Pregnancy‐related pelvic pain.Results  Compared with non‐smokers, women who smoked during pregnancy had an adjusted odds ratio of 1.2 (1.0–1.4) for overall pelvic pain, similar to women who stopped smoking in early pregnancy 1.3 (1.1–1.7). The equivalent adjusted odds ratio for severe pelvic pain was 1.2 (1.0–1.5) for smokers, and 1.5 (1.2–1.9) for women who stopped smoking. Smoking intensity, measured as number of cigarettes smoked per day, was associated with pelvic pain in a dose–response pattern. Information about smoking was collected prospectively, which makes it unlikely that differential recall alone explains the results.Conclusions  Smoking was associated with pregnancy‐related pelvic pain, with a dose–response pattern between reported smoking intensity and pelvic pain. These findings suggest a possible new risk factor for a common ailment during pregnancy.
Apgar score and perinatal death after one previous caesarean delivery
Authors: Carlsson Wallin M , Ekström P , Maršál K , Källén K 
Published: May 2010

Please cite this paper as: Carlsson Wallin M, Ekström P, Maršál K, Källén K. Apgar score and perinatal death after one previous caesarean delivery. BJOG 2010;117:1088–1097.Objective  To assess the impact of the indication for a previous caesarean section on the outcome of a subsequent delivery.Design  Population‐based cohort study.Setting  Sweden.Population  Women with two deliveries between 1987 and 2007 identified using the Swedish Medical Birth Registry.Methods  The outcome of 69 133 pregnancies after one caesarean section was compared with the outcome of 487 610 pregnancies following one vaginal delivery. The indication for the first caesarean section was estimated using a new hierarcharchical system based on information from birth records.Main outcome measures  Perinatal death, low Apgar score (less than seven at 5 minutes).Results  Infants of women with one previous caesarean section were at increased risk of low Apgar score compared with infants of women with one previous vaginal delivery (OR, 2.0; 95% CI, 1.9–2.1). The risk estimate was reduced when adjustment for maternal and fetal/infant characteristics was made (OR, 1.6; 95% CI, 1.5–1.8). The corresponding crude and adjusted odds ratios for perinatal death were 1.6 (95% CI, 1.4–1.7) and 1.1 (95% CI, 1.0–1.2), respectively. The infant outcome of the delivery after one caesarean section was mainly dependent on the indication for the first‐delivery caesarean section and, when no medical indication was present, no increase in risk was detected.Conclusions  Infants of women with one previous caesarean section were at increased risk of low Apgar score and/or perinatal death compared with infants of women with one previous vaginal delivery. The results suggest that medical conditions, not the previous caesarean section per se, contributed to the increase in risk.
Distribution of neuroendocrine regulatory peptide‐1 and ‐2, and proteolytic processing of their precursor VGF protein in the rat
Authors: Mishiro‐Sato Emi , Sasaki Kazuki , Matsuo Takashi , Kageyama Haruaki , Yamaguchi Hideki , Date Yukari , Matsubara Masako , Ishizu Takehiro , Yoshizawa‐Kumagaye Kumiko , Satomi Yoshinori , Takao Toshifumi , Shioda Seiji , Nakazato Masamitsu , Minamino Naoto 
Published: May 2010

J. Neurochem. (2010) 114, 1097–1106.AbstractNeuroendocrine regulatory peptide (NERP)‐1 and NERP‐2 are biologically active peptides recently discovered by peptidomic analysis. NERPs are processed out from the 594‐residue VGF protein which contains many prohormone convertase cleavage motifs. VGF‐deficient mice exhibit a hypermetabolic and infertile phenotype, for which VGF protein‐derived peptides including NERPs are presumably responsible. To provide a solid basis for elucidating physiological roles of NERPs, we investigated rat VGF protein processing by chromatographic and mass spectrometric analysis, and immunoblotting, using antibodies against NERPs and the VGF protein C‐terminus (VGF‐C). Cellular and tissue distribution of immunoreactive (ir) NERPs were also analyzed in the rat. Both ir‐NERP‐1 and ir‐NERP‐2, which occur abundantly in the CNS and pituitary, moderately in the gastrointestinal (GI) tract, were mainly localized in neuronal structures. Major endogenous forms of ir‐NERPs in the brain and GI tract were identified as NERP‐1, NERP‐2, and big NERP‐2 (NERP‐1 + NERP‐2), with NERP‐1 and big NERP‐2 being predominant. Regarding ir‐VGF‐C peptides, VGF[588–617], VGF[556–617], and VGF[509–617] were found to be major forms. Immunoblotting with the NERP‐2 and VGF‐C antibodies revealed processing intermediates of 10–37 kDa. Taken together, we deduce that VGF protein is primarily cleaved at 10 sites through the processing pathway common to the brain and GI tract.
Ionic dysregulations typical of ischemia provoke release of glycine and GABA by multiple mechanisms
Authors: Luccini Elisa , Romei Cristina , Di Prisco Silvia , Raiteri Maurizio , Raiteri Luca 
Published: May 2010

J. Neurochem. (2010) 114, 1074–1084.AbstractEnergy deprivation during ischemia causes dysregulations of ions, particularly sodium, potassium and calcium. Under these conditions, release of neurotransmitters is often enhanced and can occur by multiple mechanisms. The aim of this work was to characterize the modes of exit of glycine and GABA from nerve endings exposed to stimuli known to reproduce some of the ionic changes typical of ischemic conditions. Their approach was chosen instead of application of ischemic conditions because the release evoked during ischemia is mechanistically too heterogeneous. Mouse hippocampus and spinal cord synaptosomes, pre‐labeled with [3H]glycine or [3H]GABA, were exposed in superfusion to 50 mM KCl or to 10 μM veratridine. The evoked overflows differed greatly between the two transmitters and between the two regions examined. Significant portions of the K+‐ and the veratridine‐evoked overflows occurred by classical exocytosis. Carrier‐mediated release of GABA, but not of glycine, was evoked by high K+; GABA and, less so, glycine were released through transporter reversal by veratridine. External calcium‐dependent overflows were only in part sensitive to ω‐conotoxins; significant portions occurred following reversal of the plasmalemmal Na+/Ca2+ exchanger. Finally, a relevant contribution to the overall transmitter overflows came from cytosolic calcium originating through the mitochondrial Na+/Ca2+ exchanger. To conclude, ionic dysregulations typical of ischemia cause neurotransmitter release by heterogeneous mechanisms that differ depending on the transmitters and the CNS regions examined.
Multi‐actor systems and ethics
Authors: Pruyt Erik 
Published: May 2010

AbstractThis paper looks at implicit and explicit ethical aspects of research and decision making in complex issues that are characterized by combined systems and multi‐actor complexities. These social–technical issues, called multi‐actor systems, are so complex that researchers and decision makers need to reduce these complexities. This is mostly achieved by means of implicit assumptions of the research paradigms/methods chosen and explicit omission of multi‐actor and/or system aspects. Many of these paradigmatic assumptions and boundary choices are in fact implicit and explicit ethical choices. The goals of this paper are to draw attention to these ethical choices, to reveal their underlying ethical theories and to reflect on appropriate locations and functions of ethics in different strands of multi‐actor systems research and decision making.
Cost Sharing, Family Health Care Burden, and the Use of Specialty Drugs for Rheumatoid Arthritis
Authors: Karaca‐Mandic Pinar , Joyce Geoffrey F. , Goldman Dana P. , Laouri Marianne 
Published: May 2010

Objectives.To examine the impact of benefit generosity and household health care financial burden on the demand for specialty drugs in the treatment of rheumatoid arthritis (RA).Data Sources/Study Setting.Enrollment, claims, and benefit design information for 35 large private employers during 2000–2005.Study Design.We estimated multivariate models of the effects of benefit generosity and household financial burden on initiation and continuation of biologic therapies.Data Extraction Methods.We defined initiation of biologic therapy as first‐time use of etanercept, adalimumab, or infliximab, and we constructed an index of plan generosity based on coverage of biologic therapies in each plan. We estimated the household's burden by summing up the annual out‐of‐pocket (OOP) expenses of other family members.Principal Findings.Benefit generosity affected both the likelihood of initiating a biologic and continuing drug therapy, although the effects were stronger for initiation. Initiation of a biologic was lower in households where other family members incurred high OOP expenses.Conclusions.The use of biologic therapy for RA is sensitive to benefit generosity and household financial burden. The increasing use of coinsurance rates for specialty drugs (as under Medicare Part D) raises concern about adverse health consequences.
Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of α7 nicotinic receptors and internalization of NMDA receptors
Authors: Shen H , Kihara T , Hongo H , Wu X , Kem WR , Shimohama S , Akaike A , Niidome T , Sugimoto H 
Published: May 2010

BACKGROUND AND PURPOSEGlutamate excitotoxicity may be involved in ischaemic injury to the CNS and some neurodegenerative diseases, such as Alzheimer's disease. Donepezil, an acetylcholinesterase (AChE) inhibitor, exerts neuroprotective effects. Here we demonstrated a novel mechanism underlying the neuroprotection induced by donepezil.EXPERIMENTAL APPROACHCell damage in primary rat neuron cultures was quantified by lactate dehydrogenase release. Morphological changes associated with neuroprotective effects of nicotine and AChE inhibitors were assessed by immunostaining. Cell surface levels of the glutamate receptor sub‐units, NR1 and NR2A, were analyzed using biotinylation. Immunoblot was used to measure protein levels of cleaved caspase‐3, total NR1, total NR2A and phosphorylated NR1. Immunoprecipitation was used to measure association of NR1 with the post‐synaptic protein, PSD‐95. Intracellular Ca2+concentrations were measured with fura 2‐acetoxymethylester. Caspase 3‐like activity was measured using enzyme substrate, 7‐amino‐4‐methylcoumarin (AMC)‐DEVD.KEY RESULTSLevels of NR1, a core subunit of the NMDA receptor, on the cell surface were significantly reduced by donepezil. In addition, glutamate‐mediated Ca2+entry was significantly attenuated by donepezil. Methyllycaconitine, an inhibitor of α7 nicotinic acetylcholine receptors (nAChR), inhibited the donepezil‐induced attenuation of glutamate‐mediated Ca2+entry. LY294002, a phosphatidyl inositol 3‐kinase (PI3K) inhibitor, had no effect on attenuation of glutamate‐mediated Ca2+entry induced by donepezil.CONCLUSIONS AND IMPLICATIONSDecreased glutamate toxicity through down‐regulation of NMDA receptors, following stimulation of α7 nAChRs, could be another mechanism underlying neuroprotection by donepezil, in addition to up‐regulating the PI3K‐Akt cascade or defensive system.
Two stages of granulite facies metamorphism in the eastern Himalayan syntaxis, south Tibet: petrology, zircon geochronology and implications for the subduction of Neo‐Tethys and the Indian continent beneath Asia
Authors: ZHANG Z. M. , ZHAO G. C. , SANTOSH M. , WANG J. L. , DONG X. , LIOU J. G. 
Published: May 2010

AbstractThe eastern Himalayan syntaxis in southeastern Tibet consists of the Lhasa terrane, High Himalayan rocks and Indus‐Tsangpo suture zone. The Lhasa terrane constitutes the hangingwall of a subduction zone, whereas the High Himalayan rocks represent the subducted Indian continent. Our petrological and geochronological data reveal that the Lhasa terrane has undergone two stages of medium‐P metamorphism: an early granulite facies event at c. 90 Ma and a late amphibolite facies event at 36–33 Ma. However, the High Himalayan rocks experienced only a single high‐P granulite facies metamorphic event at 37–32 Ma. It is inferred that the Late Cretaceous (c. 90 Ma) medium‐P metamorphism of the southern Lhasa terrane resulted from a northward subduction of the Neo‐Tethyan ocean, and that the Oligocene (37–32 Ma) high‐P (1.8–1.4 GPa) rocks of the High Himalayan and coeval medium‐P (0.8–1.1 GPa) rocks of the Lhasa terrane represent paired metamorphic belts that resulted from the northward subduction of the Indian continent beneath Asia. Our results provide robust constraints on the Mesozoic and Cenozoic tectonic evolution of south Tibet.
Linking Glycemic Control and Executive Function in Rural Older Adults with Diabetes Mellitus
Authors: Nguyen Ha T. , Grzywacz Joseph G. , Arcury Thomas A. , Chapman Christine , Kirk Julienne K. , Ip Edward H. , Bell Ronny A. , Quandt Sara A. 
Published: May 2010

OBJECTIVES: To examine the association between glycemic control and the executive functioning domain of cognition and to identify risk factors for inadequate glycemic control that may explain this relationship.DESIGN: Cross‐sectional study.SETTING: In‐person interviews conducted in participants' homes.PARTICIPANTS: Ninety‐five rural older African Americans, American Indians, and whites with diabetes mellitus (DM) from three counties in south‐central North Carolina.MEASUREMENTS: Participants underwent uniform evaluations. Glycemic control was measured using a validated method, and executive function was assessed using a previously established set of measures and scoring procedure. Information pertaining to medication for treatment of DM, knowledge of DM, and DM self‐care behaviors were obtained.RESULTS: In linear regression models adjusting for sex, age, education, ethnicity, duration of DM, and depressive symptoms, executive function was significantly associated with glycemic control. A 1‐point higher executive function score was associated with a 0.47 lower glycosylated hemoglobin value (P=.01). The association between glycemic control and executive function became nonsignificant (P=.08) when controlling for several glycemic control risk factors, including use of DM medication and DM knowledge.CONCLUSION: These results suggest that poor glycemic control is associated with impairments in performance on composite measures of executive function and that modifiable risk factors for glycemic control such as use of DM medication and DM knowledge may explain this relationship.
Renin Angiotensin System Gene Polymorphisms Modify Angiotensin‐Converting Enzyme Inhibitors' Effect on Cognitive Function: The Health, Aging and Body Composition Study
Authors: Hajjar Ihab , Kritchevsky Stephen , Newman Anne B. , Li Rongling , Yaffe Kristine , Simonsick Eleanor M. , Lipsitz Lewis A. ,   for the Health, Aging and Body Composition Study
Published: May 2010

OBJECTIVES: To investigate the effect of polymorphisms in renin angiotensin system genes on the association between angiotensin‐converting enzyme inhibitor (ACEI) exposure and global and executive cognitive function in the Health, Aging and Body Composition study.DESIGN: Cohort study.SETTING: Community.PARTICIPANTS: Three thousand seventy‐five participants: mean age 73.6, 58% Caucasian, 52% female, 15% taking ACE‐Is, 8 years of follow‐up.MEASUREMENTS: The outcomes were longitudinal change in Executive Clock Drawing Test‐1 (CLOX1), the Digit Symbol Substitution test, and the Modified Mini‐Mental State Examination. The genetic polymorphisms included angiotensin‐converting enzyme insertion deletion (ACEID) in the ACE gene and the M235T and 6AG polymorphisms in the angiotensinogen (AGT) gene.RESULTS: For the CLOX1 outcome, there was significant interaction between 6AG and M235T polymorphisms in the AGT gene and angiotensin‐converting enzyme inhibitors (ACE‐Is) in Caucasian participants (P=.01 for both polymorphisms) independent of blood pressure levels. Specifically, ACE‐I exposure was protective against CLOX1 score decline in carriers of the AA genotype of the 6AG and the CC genotype of the M235T (for the ACE‐I vs non‐ACE‐I groups, P=.01 for 6AG and P=.005 for M235T) but not the other genotypes. These associations were not significant with other cognitive tests, with ACEID, or in African Americans.CONCLUSION: ACE‐Is may provide a protective effect on executive function in Caucasians with AGT gene polymorphisms known to be associated with greater renin angiotensin system activity. If confirmed in a pharmacogenetic trial, ACE‐Is may be found to have additional cognitive protection in a select group of elderly individuals.
Hearing Impairment Affects Older People's Ability to Drive in the Presence of Distracters
Authors: Hickson Louise , Wood Joanne , Chaparro Alex , Lacherez Philippe , Marszalek Ralph 
Published: May 2010

OBJECTIVES: To investigate the effects of hearing impairment and distractibility on older people's driving ability, assessed under real‐world conditions.DESIGN: Experimental cross‐sectional study.SETTING: University laboratory setting and an on‐road driving test.PARTICIPANTS: One hundred seven community‐living adults aged 62 to 88. Fifty‐five percent had normal hearing, 26% had a mild hearing impairment, and 19% had a moderate or greater impairment.MEASUREMENTS: Hearing was assessed using objective impairment measures (pure‐tone audiometry, speech perception testing) and a self‐report measure (Hearing Handicap Inventory for the Elderly). Driving was assessed on a closed road circuit under three conditions: no distracters, auditory distracters, and visual distracters.RESULTS: There was a significant interaction between hearing impairment and distracters, such that people with moderate to severe hearing impairment had significantly poorer driving performance in the presence of distracters than those with normal or mild hearing impairment.CONCLUSION: Older adults with poor hearing have greater difficulty with driving in the presence of distracters than older adults with good hearing.
Two‐Year Effects of Interdisciplinary Intervention for Hip Fracture in Older Taiwanese
Authors: Shyu Yea‐Ing L. , Liang Jersey , Wu Chi‐Chuan , Su Juin‐Yih , Cheng Huey‐Shinn , Chou Shih‐Wei , Chen Min‐Chi , Yang Ching‐Tzu , Tseng Ming‐Yueh 
Published: May 2010

OBJECTIVES: To explore the 2‐year outcomes of an interdisciplinary intervention for elderly patients with hip fracture.DESIGN: Randomized experimental design.SETTING: A 3,000‐bed medical center in northern Taiwan.PARTICIPANTS: Patients with hip fracture (N=162): 80 in the intervention group and 82 in the usual care control group.INTERVENTION: An interdisciplinary program of geriatric consultation, continuous rehabilitation, and discharge planning.MEASUREMENTS: Outcomes (clinical outcomes, self‐care ability, health‐related quality of life (HRQoL), service utilization, and depressive symptoms) were assessed 1, 3, 6, 12, 18, and 24 months after discharge. Self‐care ability (ability to perform activities of daily living (ADLs)) was measured using the Chinese Barthel Index. HRQoL was measured using the Medical Outcomes Study 36‐item Short Form Survey, Taiwan version (SF‐36). Depressive symptoms were measured using the Chinese Geriatric Depression Scale, short form.RESULTS: Subjects in the intervention group had significantly better ratios of hip flexion (β=5.43, P<.001), better performance on ADLs (β=9.22, P<.001), better recovery of walking ability (odds ratio (OR)=2.23, P<.001), fewer falls (OR=0.56, P=.03), fewer depressive symptoms (β=−1.31, P=.005), and better SF‐36 physical summary scores (β=6.08, P<.001) than the control group during the first 24 months after discharge. The intervention did not affect the peak force of the fractured limb's quadriceps, mortality, service utilization, or SF‐36 mental summary score.CONCLUSION: The interdisciplinary intervention for hip fracture benefited elderly persons with hip fracture by improving clinical outcomes, self‐care ability, and physical health–related outcomes and by decreasing depressive symptoms during the first 24 months after hospital discharge.