bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced recovery after surgery (ERAS): A budding concept in neonatal intestinal surgery
Authors: Erram Harika , Varshney Preeti Goyal , Gupta Anshu 
Published: June 2024

Enhanced recovery after surgery (ERAS) is a multidisciplinary approach, widely used in adults and children for improving patient care with reduced length of hospital stay and medical costs. However, it is poorly established and perceived as unimplementable in neonates. Recently, ERAS guidelines consisting of 17 recommendations for perioperative care in neonatal intestinal surgery are laid down by the ERAS society. To elicit the feasibility of implementing ERAS protocol, we did an observational pilot study in neonates undergoing intestinal surgery at a tertiary centre to know the number of recommendations from ERAS guidelines already being followed routinely.Data was collected for the neonates undergoing intestinal surgery for three months. All the relevant details were noted and analysed to find out the number of recommendations from ERAS guidelines already being implemented and the postoperative outcome of these neonates.Twelve neonates underwent intestinal surgery for obstruction and atresia during the study period. Eight out of 17 ERAS guidelines were already followed as a routine protocol in all these patients. Nine patients were extubated on table, one patient was extubated within 24 hours of surgery and two patients succumbed to death. Ten neonates were discharged from hospital within 6-8 days of surgery. Many recommendations from ERAS guidelines for neonatal intestinal surgery are already being followed routinely, suggesting that the implementation of complete ERAS protocol is easily possible, which may further improve the perioperative outcome with reduced length of hospital stay.
Efficacy of different irrigation techniques in removal of N-acetyl cysteine as an intracanal medicament- An study
Authors: Narvekar Pranjali S. , Velmurugan Shruthi , Doddwad Preeti K , Shivanand Sunita 
Published: June 2024

Intra canalmedicament must be completely removed from the pulp space for better penetration of sealers. Various methods of irrigant delivery are used for removal of medicament from root canals. Removal of N-acetyl cysteine when used as an intracanal medicament hasn't been studied yet.To compare efficacy of different irrigation techniques, ultrasonic, sonic, navi tips, side vented needles in removal of N-acetyl cysteine as an intracanal medicament- an study Fifty-two maxillary anterior teeth were decoronated and standardized to a root length of 13 mm. Root canals were prepared with Protaper Universal rotary system. N-acetyl cysteine paste was placed in root canals with lentulospiral and kept in an incubator for 7 days. Then four groups (n=13) were established according to the removal technique- Group 1- Passive ultrasonic irrigation, Group 2- Sonic irrigation, Group 3- Manual irrigation with NaviTip, Group 4- Manual irrigation with side vented needles. Each tip was placed 2 mm short of working length and irrigation was done using 5.25% sodium hypochlorite. Final irrigation was done, then roots were split buccolingually and evaluated for residual medicament under stereomicroscope at 24x magnification. Done using Kruskal-Wallis and Mann-Whitney tests (P ≤ 0.05). In coronal and middle third, there was significant difference in removal of medicament by Group 1- Passive ultrasonic irrigation compared to other techniques, whereas, in apical third Group 2- Sonic irrigation showed better result. Group 3-Manual irrigation with NaviTip and Group 4- Manual irrigation with side- vented needles was significantly less effective than other techniques.Use of irrigants with activation devices like ultrasonic and sonic revealed improved removal of N- acetyl cysteine intracanal medicament.
O mercado de trabalho das pessoas com transtorno do espectro autista (TEA)
Authors: De Azevedo Cardoso Lucas Tomás , Castilho Adriana Guedes de 
Published: June 2024

<p>A presente pesquisa tem como objetivo refletir sobre as dificuldades que ocorrem para efetivar a inclusão das pessoas com autismo no mercado de trabalho. Essa pesquisa se faz relevante, pois busca contribuir para o desenvolvimento de estratégias e políticas que promovam a inclusão efetiva desses indivíduos, valorizando suas habilidades e potenciais no ambiente de trabalho. Para alcançar esse propósito, foram coletados dados por meio de questionários enviados aos gestores de Recursos Humanos, a fim de compreender o atual processo de inclusão e os obstáculos enfrentados nesse contexto. Além disso, a revisão bibliográfica desempenhou um papel fundamental nesse estudo, permitindo identificar a obrigatoriedade estabelecida pela Lei nº 8.213, de 24 de julho de 1991, conhecida como lei de cotas, que norteia a inclusão de pessoas com deficiência em geral, estabelecendo a reserva de vagas para esses indivíduos no mercado de trabalho. Os resultados revelaram a existência de estereótipos na contratação de pessoas com autismo, bem como uma tendência de não contratação daqueles com deficiência intelectual. </p>
Gestão de mídia social: estratégias para impulsionamento do negócio com uso do aplicativo Instagram
Authors: Estevam Diognnys Cardoso , Alves de Freitas Bruna Lyra , Fernandes Alves Ana Isabela , Da Silva Flaviana Alves , Da Silva Raniery Bezerra 
Published: June 2024

<span>Este trabalho tem como objetivo analisar o uso da rede social Instagram da empresa Limpe Fácil Paris, localizadas na cidade de Guarabira, que atua com a comercialização de produtos de limpeza, como ferramenta de impulsionamento de negócio. O foco do trabalho foi fazer o posicionamento da marca por meio do aprimoramento do perfil do Instagram, de modo a atrair seguidores como potenciais clientes e impulsionar as vendas. A pesquisa é do tipo descritiva e foram analisados dados quantitativos coletados a partir do próprio mecanismo de mensuração da plataforma, o Instagram, envolvendo: alcance, engajamento, seguidores, perfil do cliente em relação a sexo, faixa etária e localização. Estes dados foram coletados a partir da prestação de serviço ofertada a empresa Limpe Fácil Paris, pela Empresa Júnior do Instituto Federal da Paraíba (IFPB), do campus Guarabira, a Singular Empresa Júnior. A partir dos resultados obtidos, pode-se perceber que a ferramenta Instagram, de fato atua como uma impulsionadora para o desenvolvimento dos negócios, sobretudo quando bem planejada. No caso desta pesquisa, isso pode ser percebido, principalmente, pelo aumento de contas alcançadas e pelas ações de engajamento, que estão relacionados a interações, como comentários e compartilhamentos. Percebe-se que o aumento de seguidores não foi significativo neste período de atuação junto à empresa, o que nos mostra que para atuar nas mídias digitais a empresa deve concentrar esforços diários e ter uma postura ambiciosa diante das possibilidades de alcance que o meio digital proporciona.</span>
A CASE REPORT: EARLOBE RECONSTRUCTION ON CONGENITAL AURICULAR LOBE DEFECT USING Z-PLASTY
Authors: Amatullah Nida’ Fahima , Iswinarno Doso Saputro  
Published: June 2024

Highlights:

Congenital ear defects typically result from growth failures during the fifth to ninth weeks of gestation or from mechanical stress during this period.
Auricular lobuloplasty using the Z-plasty flap technique effectively addresses earlobe defects, resulting in optimal aesthetic outcomes with no keloid formation, minimal scarring, and no complications.

Abstract:
Introduction: Earlobe defects, often due to embryonal growth failure or injury, can affect aesthetics and social interactions despite not impacting hearing. Earlobe defect can be formed either from birth as congenital defect or secondary manifestation of other causes such as tumor and external factor such as earring usage or trauma. This study aimed to address these issues by performing auricular lobuloplasty using a Z-plasty flap technique. The procedure, crucial for protecting the auditory canal and facilitating eyeglass use, was successful in achieving the desired aesthetic outcome. Data on microtia prevalence, particularly in Indonesia, highlights the need for such reconstructive surgeries.
Case Illustration: A 9-year-old boy underwent auricular lobuloplasty to correct a cleft earlobe deformity, which caused social discomfort. The surgery, performed under general anesthesia, utilized a Z-plasty technique to lengthen and reorient the scar. Postoperative care included wound dressing changes and oral pain medication. After two weeks, satisfactory results were observed with no reported complications.
Discussion: The study on congenital ear deformities focuses on Z-plasty for earlobe reconstruction, detailing classifications, surgical techniques, and case results. The surgery was successful with minimal scarring and no keloid formation. Using Weerda's classification, the technique showed minimal scarring and no keloid formation. The approach, emphasizing proper skin envelope and alignment with Langer lines, offers effective aesthetic restoration, making it a valuable reference for future earlobe reconstruction cases.
Conclusion: Utilizing Z-plasty for earlobe defect reconstruction aids in improving the earlobe's appearance with minimal to no complications.
Enterprise Risk Management pada Perguruan Tinggi Swasta (Studi Kasus di STMA Trisakti)
Authors: Syahrial Syahrial Sidik , Wahyuari Wahyuari , Julianto Heppy 
Published: June 2024

Tujuan dari penulisan ini adalah untuk menganalisis penerapan manajemen risiko pada perguruan tinggi di Sekolah Tinggi Manajemen Asuransi Trisakti. Metode penelitian menggunakan desain penelitian eksploratif, karena tujuan penelitian ini adalah untuk memahami permasalahan manajemen risiko pada STMA Trisakti. Data diperoleh dengan melakukan wawancara dan barinstorming dengan ketua program studi, kepala bagian, dan Kepala Pusat, juga dengan menggunakan data sekunder yaitu jumlah mahasiswa, jumlah, dosen, dan data lainnya. Tahapan analisis dilakukan melalui identifikasi risiko, penilaian dan evaluasi risiko, perencanaan mitigasi risiko dan analisis serta interpretasi data. Berdasarkan hasil identifikasi risiko, terdapat 7 risiko inherent yang bisa berdampak signifikan terhadap sustainability STMA Trisakti. Berdasarkan risk profile dari ketujuh identifikasi risiko, risiko 1 dan 6 berdampak kualitatif terhadap penurunan peringkat akreditasi, risiko 2, 3 dan 7 berdampak terhadap tidak tercapainya sasaran kinerja, risiko 4 dan 5 dapat berdampak terhadap penurunan klasterisasi Nasional Perguruan Tinggi. Dampak kuantitatif Risiko 1, 2, 3 dan 6 berdampak terhadap kerugian institusi, risiko 4, 5 dan 7 berdampak terhadap rendahnya penyerapan anggaran (cost center). Beberapa risiko memerlukan penangan dalam waktu yang tidak singkat seperti risiko 2, 4 dan 7 dapat mengakibatkan risiko residual tidak sesuai dengan target risiko yang diharapkan (risk appetite), sehingga diperlukan penanganan risiko secara berkelanjutan. Penelitian ini memiliki keterbatasan yaitu identifikasi risiko tidak dilakukan secara mendalam pada semua unit kerja. Penelitian mendatang diharapkan agar identifikasi risiko dilakukan pada semua unit kerja di Perguruan Tinggi, sehingga risiko yang ada dapat segera dimitigasi dan dilakukan perbaikan segera.

Kata Kunci: Enterprise Risk Management, Perguruan Tinggi
Supplementation of Sakura Block Plus in Beef Cattle Fed with Palm Fronds and Its Effect on Nutrient Digestibility
Authors: Jarmuji Jarmuji , Badarina Irma , Warly Lili 
Published: June 2024

Sakura Block Plus is a modification of Sakura Block, incorporating 6% earthworms and palm kernel cake as substitutes for corn. The objective of this study was to evaluate the supplementation of Sakura Block Plus in palm frond feed on the nutrient digestibility of beef cattle. The research design employed a Latin Square Design (LSD) with treatments P0 (10% Sakura Block Plus), P1 (8% Sakura Block Plus), P2 (10% Sakura Block Plus), and P3 (12% Sakura Block Plus). Four male beef cattle, 18 months old, weighing approximately ± 110 kg, were utilized throughout four treatment periods, each lasting 15 days. The results of the study indicated a significant improvement in the 12% Sakura Block Plus treatment concerning the digestibility of Neutral Detergent Fiber (NDF), Acid Detergent Fiber (ADF), and hemicellulose. In conclusion, the supplementation of Sakura Block Plus at the 12% level in palm frond feed resulted in the most optimal nutrient digestibility.
Dynamic nexus between poverty and indicators for sustainable transportation in MENA countries: Evidence from panel PMG-ARDL approach
Authors: Ouni Manel , Abdallah Khaled Ben 
Published: June 2024

Abstract

Sustainable transportation indicators have attracted significant attention from policymakers, engineers, and academics. This heightened interest can be attributed to the transportation industry's impact on economic growth, poverty alleviation, and the environment. While numerous studies have explored the relationships between the transportation sector, poverty, economic growth, and environmental degradation on a global scale, there is a noticeable research gap concerning the Middle East and North Africa (MENA) region. This study addresses this gap by investigating the nexus between poverty, transportation-related CO2 emissions, economic growth, trade openness, urbanization, road infrastructure and transportation energy consumption in 14 MENA regions from 1983 to 2021. To achieve this objective, this investigation employs the panel pooled mean group-autoregressive distributed lag (PMG-ARDL) model to explore the long-term relationships among these variables. The findings, as revealed by the Dumitrescu-Hurlin panel causality, show a reciprocal relationship between poverty, transportation-related CO2 emissions and economic growth. Moreover, the study identifies a unidirectional relationship running from road infrastructure to poverty. Additionally, a unidirectional causality runs from both economic growth and poverty to transportation-related energy consumption. Furthermore, a bidirectional causality exists between trade openness and transport CO2 emissions, and a unidirectional causality running from trade openness to economic growth. These findings emphasize the importance of policymakers to adopt strategies that equally prioritize poverty alleviation, environmental sustainability, and economic development to attain sustainable transportation in MENA region.
A new objective diagnostic method for CHF that lays the foundation for objective classification and precision medicine for chronic heart failure
Authors: Vanni Rosalba 
Published: June 2024

Abstract

Algebraic equations from a mathematical model to experimental data relating to venous and arterial blood (HCO3-, \({\text{P}\text{C}\text{O}}_{2}\)), cardiac output, and exhaled \({\text{V}\text{C}\text{O}}_{2}\) of a group of patients with chronic heart failure (CHF) belonging to New York Heart Association class III were applied. The aim of this study was to verify whether several measurable physiological parameters were significantly different among three different groups (CHF class III patients, a control group of the same age, and a group of young and athletic subjects) and, therefore, to verify whether the algebraic equations used were useful for objectively diagnosing patients with CHF. The comparison among the results of the three groups was extremely significant, so much to unquestionably highlight the class III CHF group compared to the other two groups and therefore allowing the CHF group to be objectively characterized both at rest and during exercise. This new diagnostic method performed a first objective pathophysiological characterization of CHF class III patients, laying the foundation for an objective classification of the four classes of CHF patients and subsequent precision medicine.
Voiding Cystourethrography – Do We Over-do It?
Authors: Zivkovic Dragana , Fratric Ivana , Lukic Maja Samardzic , Ostoic Marijana 
Published: June 2024

Abstract

Background: Voiding cystourethrography is primary used to detect vesico-ureteric reflux and is considered “gold standard” diagnostic examination for this condition. It can be ordered by pediatricians, nephrologists, emergency room pediatricians and urologists. Negative effects of Voiding cystourethrographyinclude its invasiveness, radiation exposure and risk of iatrogenic urinary tract infection. Our aim is to determine if we can reduce the number of voiding cystourethrography examinations performed at our Institute.
Methods: Retrospective study was conducted with approval of the Ethical Review Board using clinical data of the patients who underwent voiding cystourethrography over the period of 12 months. Indicators (age of the patient, gender, referring specialist – urologist or nephrologists and indications for voiding cystourethrography) were analyzed using Chi-square, Fisher’s exact and Mann-Whitney test. Possible impact of the above mentioned indicators on the result of the voiding cystourethrography was analyzed using logistic regressive analysis.
Results: Total of 197 voiding cystourethrographies were analyzed. Mann-Whitney U test did not show statistically significant age difference between the patients with normal (median age 3 years) and pathologic (median age 2.5 years) findings on voiding cystourethrography (Z=-0.415, p=0.678). Chi-square test showed that patients with single urinary infection and other indications have a higher chance of normal result on voiding cystourethrography (0.041 and 0.011 respectively). Logistic regressive analysis showed that patients whose referring specialist was
urologist had 2.06 times higher chance for having pathologic finding on voiding cystourethrography (b=-0.810, p=0.007, odds ratio=0.445) compared to those referred by nephrologists.
Conclusions: It is used as the “gold standard” radiographic test to diagnose vesicoureteral reflux. It is however associated by necessary radiation exposure. At our Institute pediatric urologists indicate voiding cystourethrography more cautiously compared to pediatric nephrologists. By avoiding voiding cystourethrography after single urinary tract infection and for other indications we could reduce the number of voiding cystourethrographies performed.
Increased expression of REG3A promotes tumorigenic behavior in triple negative breast cancer cells
Authors: Jin Xiaoxia , Yang Shuyun , Lu Xiaoyun , Chen Xudong , Dai Wencheng 
Published: June 2024

Abstract

Background:Identifying new targets in triple negative breast cancer (TNBC) remains critical. REG3A (regenerating islet-derived protein 3A), a calcium-dependent lectin protein, was thoroughly investigated for its expression and functions in breast cancer.Methods:Bioinformatics and local tissue analyses were employed to identify REG3A expression in breast cancer. Genetic techniques were employed to modify REG3A expression, and the resulting effects on the behaviors of breast cancer cells were examined. Subcutaneous xenograft models were established to investigate the involvement of REG3A in the in vivo growth of breast cancer cells.Results:Analysis of the TCGA database uncovered increasedREG3Alevels in human breast cancer tissues. Additionally,REG3AmRNA and protein levels were elevated in TNBC tissues of locally treated patients, contrasting with low expression in adjacent normal tissues. In primary human TNBC cells REG3A shRNA notably hindered cell proliferation, migration, and invasion while triggering caspase-mediated apoptosis. Similarly, employing CRISPR-sgRNA for REG3A knockout showed significant anti-TNBC cell activity. Conversely, REG3A overexpression bolstered cell proliferation and migration. REG3A proved crucial for activating the Akt-mTOR cascade, as evidenced by decreased Akt-S6K1 phosphorylation upon REG3A silencing or knockout, which was reversed by REG3A overexpression. A constitutively active mutant S473D Akt1 (caAkt1) restored Akt-mTOR activation and counteracted the proliferation inhibition and apoptosis induced by REG3A knockdown in breast cancer cells. Crucially, REG3A played a key role in maintaining mTOR complex integrity. Bioinformatics identified zinc finger protein 680 (ZNF680) as a potential REG3A transcription factor. Knocking down or knocking out ZNF680 reduced REG3A expression, while its overexpression increased it in primary breast cancer cells. Additionally, enhanced binding between ZNF680 protein and the REG3A promoter was observed in breast cancer tissues and cells.In vivo, REG3A shRNA significantly inhibited primary TNBC cell xenograft growth. In REG3A-silenced xenograft tissues, reduced REG3A levels, Akt-mTOR inhibition, and activated apoptosis were evident.Conclusion:ZNF680-caused REG3A overexpression drives tumorigenesis in breast cancer possibly by stimulating Akt-mTOR activation, emerging as a promising and innovative cancer target.
A massive and potentially ancient antipatharian colony at a seamount in the Northwest Pacific
Authors: Reimer James Davis , Yanagi Kensuke , Castelló Guillermo Mironenko , Yokooka Hiroyuki , Koeda Keita , Tsuchida Shinji , Fujiwara Yoshihiro 
Published: June 2024

Abstract

Anthozoans are ecosystem engineers and contribute to creating intricate benthic communities that often harbor high levels of marine biodiversity. Here, we report on an extraordinarily large antipatharian colony observed on the Ritto Seamount in the Northwest Pacific. Based on colony form and DNA barcoding results, we identified the colony as Leiopathes cf. glaberrima. From in situ observations, we estimate the size of the colony as approximately 308 cm in height, 441 cm in width, with a central stem of 27.9 cm in diameter. If growth rates of Leiopathes species in this region of the Pacific Ocean are similar to those previously reported from Hawai’i, this colony may potentially be approximately several thousand years old, placing it among the longest-lived marine organisms reported. Seamounts in this region and such large antipatharians and other anthozoan colonies should be targeted for more biodiversity investigation and future conservation.
Assessing Drinking Water Quality in El-Oued, South-East Algeria, Utilizing the Groundwater Pollution Index (GPI) and the Synthetic Pollution Index (SPI) model
Authors: ZAIR NADJET , ATTOUI BADRA , MILOUDI ABDELMONEM , ABDERRAHMANE KHECHEKHOUCHE , SOUYEI BELGACEM 
Published: June 2024

Abstract

To assess the suitability of deep groundwater in El-Oued for drinking purposes and quantify its hydrochemical characteristics, a study was conducted on 22 boreholes. The alteration and dissolution of carbonates, evaporates, salts, and partly silicates, ion exchange, and evaporation are the main hydrogeochemical progressions leading to water salinization. The combination of these processes, in an environment conducive to the concentration of dissolved elements, has positively contributed to the evolution of the salinity of these waters in the research region. The results of Groundwater Pollution Index (GPI) show that 18.18%, 54.54%, and 27.27% were weakly polluted, moderately, and highly polluted for drinking consumption, respectively. The examination of the Synthetic Pollution Index (SPI) findings indicates that 9.09% were deemed potable, while 36.36% exhibited weak pollution, 36.36% displayed moderate pollution, and 18.18% were classified as highly polluted for drinking purposes. Potable water sources are generally limited and are located in the northeast and in the vicinity of the city of Ourmes in the study zone according to the spatial distribution maps of GPI model and SPI model.