bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology of early vs late recurrence among women with early stage estrogen receptor–positive breast cancer in the Pathways Study
Authors: Chua Alfredo V , Sheng Haiyang , Liang Emily , Gandhi Shipra , Kwan Marilyn L , Ergas Isaac J , Roh Janise M , Laurent Cecile A , Yan Li , Khoury Thaer , Ambrosone Christine B , Kushi Lawrence H , Yao Song 
Published: June 2024

Abstract

Background
Relatively little is known about the differences in prognostic factors for early vs late recurrence among women with early stage estrogen receptor–positive breast cancer.

Methods
We analyzed factors related to early (&lt;5 years) vs late (≥5 years) recurrence in 2992 women with stage I-IIB estrogen receptor–positive breast cancer in the Pathways Study, a prospective cohort of women with breast cancer enrolled between 2006 and 2013, with ascertainment of recurrence and death through December 2021.

Results
After a median follow-up of 13.3 years, 341 (13.8%) women had recurrences, including 181 (53.7%) with late recurrence. Higher stage and grade were associated with recurrence regardless of timing, whereas progesterone receptor negativity was associated with early but not late recurrence. Receipt of endocrine therapy was associated with reduced risk of overall recurrence, but the length of endocrine therapy was not statistically significant in multivariable models. Minoritized racial and ethnic groups, including Asian, Black, and Hispanic women, had higher risk of early but not late recurrence compared to non-Hispanic White women. The trend of higher risk of early recurrence among these groups remained after adjustment for clinical, demographic, and socioeconomic factors but was statistically significant only in Asian women.

Conclusions
Our study revealed potentially important distinctions for early vs late recurrence, including the associations with progesterone receptor negativity and self-identified race and ethnicity. Possible higher risk of early recurrence among Asian, Black, and Hispanic women provides novel evidence for the existence of disparities in cancer outcomes, even within the breast cancer subtype indicative of generally good prognosis.
The genomic landscape of breast and non-breast cancers from individuals with germline CHEK2 deficiency
Authors: Hinić Snežana , van der Post Rachel S , Vreede Lilian , Schuurs-Hoeijmakers Janneke , Koene Saskia , Jansen Erik A M , Bervoets-Metge Franziska , Mensenkamp Arjen R , Hoogerbrugge Nicoline , Ligtenberg Marjolijn J L , de Voer Richarda M 
Published: June 2024

Abstract
CHEK2 is considered to be involved in homologous recombination repair (HRR). Individuals who have germline pathogenic variants (gPVs) in CHEK2 are at increased risk to develop breast cancer and likely other primary cancers. PARP inhibitors (PARPi) have been shown to be effective in the treatment of cancers that present with HRR deficiency—for example, caused by inactivation of BRCA1/2. However, clinical trials have shown little to no efficacy of PARPi in patients with CHEK2 gPVs. Here, we show that both breast and non-breast cancers from individuals who have biallelic gPVs in CHEK2 (germline CHEK2 deficiency) do not present with molecular profiles that fit with HRR deficiency. This finding provides a likely explanation why PARPi therapy is not successful in the treatment of CHEK2-deficient cancers.
Travel-time barriers to specialized cancer care for adolescents and young adults with acute lymphoblastic leukemia
Authors: Parsons Helen M , Muffly Lori S , Garcia Ariadna , Zhang Amy , Miller Kate , Van Riper David , Knowles Kate , Keegan Theresa H 
Published: June 2024

Abstract

Background
Prior studies demonstrate that 20%-50% of adolescents and young adults (age 15-39 years) with acute lymphoblastic leukemia (ALL) receive care at specialty cancer centers, yet a survival benefit has been observed for patients at these sites. Our objective was to identify patients at risk of severe geographic barriers to specialty cancer center–level care.

Methods
We used data from the North American Association of Central Cancer Registries Cancer in North America database to identify adolescent and young adult ALL patients diagnosed between 2004 and 2016 across 43 US states. We calculated driving distance and travel time from counties where participants lived to the closest specialty cancer center sites. We then used multivariable logistic regression models to examine the relationship between sociodemographic characteristics of counties where adolescent and young adult ALL patients resided and the need to travel more than 1 hour to obtain care at a specialty cancer center.

Results
Among 11 813 adolescent and young adult ALL patients, 43.4% were aged 25-39 years, 65.5% were male, 32.9% were Hispanic, and 28.7% had public insurance. We found 23.6% of adolescent and young adult ALL patients from 60.8% of included US counties would be required to travel more than 1 hour one way to access a specialty cancer center. Multivariable models demonstrate that patients living in counties that are nonmetropolitan, with lower levels of educational attainment, with higher income inequality, with lower internet access, located in primary care physician shortage areas, and with fewer hospitals providing chemotherapy services are more likely to travel more than 1 hour to access a specialty cancer center.

Conclusions
Substantial travel-related barriers exist to accessing care at specialty cancer centers across the United States, particularly for patients living in areas with greater concentrations of historically marginalized communities.
Reflections on a communication journey into professionalism and organizing
Authors: McAllum Kirstie , Barbour Joshua B , Fox Stephanie , Matte Frédérik 
Published: June 2024

AbstractMuch research in the field of communication studies has evidenced a ‘performative turn’ in how it views professionalism, professionals, and the professions. This special issue, Opening up the meanings of ‘the professional’, professional organizations, and professionalism in communication studies, documents this process and lays out a research agenda in and from communication studies that can inform scholarship on professionalism and organizing. In addition to mapping out and contextualizing the multiple, contested meanings of professionalism, particularly in novel or ‘non-standard’ contexts, it shows how workers enact, negotiate, reify, and resist the meanings of professionalism in both aspirational and exclusionary ways. When we shift the focus from professional experts (and the institutional apparatus that protects their status, autonomy, and authority) to expertise, as Ashcraft suggests in her contribution to this special issue, scholarly analysis needs to account for an entire network of actors, ideas, instruments, and forms of organizing that allow for successful—or failed—performances of expertise and understand that those performances rest on economies of difference. Economies of difference are distinctions among the sorts of work, workers, and working that wield political power in that they implicate social structures and dictate how specialized expertise is and can be deployed and recognized. Economies of difference create and benefit from inequities. The articles in this special issue offer empirical and conceptual windows into the contested and messy performance of professionalism, how it serves as a resource for some and a constraint for others, and how its contemporary meaning is potentially disrupted.
Wedelolactone suppresses breast cancer growth and metastasis via regulating TGF-β1/Smad signaling pathway
Authors: Li Hui , Hou Manting , Zhang Ping , Ren Lutong , Guo Yuanyuan , Zou Liang , Cao Junling , Bai Zhaofang 
Published: June 2024

Abstract

Objective
Breast cancer is a malignant tumor with high invasion and metastasis. TGF-β1-induced epithelial-mesenchymal transition (EMT) is crucially involved in the growth and metastasis of breast cancer. Wedelolactone (Wed) is extracted from herbal medicine Ecliptae Herba, which is reported to have antineoplastic activity. Here, we aimed to elucidate the efficacy and mechanism of Wed against breast cancer.

Methods
The effects of Wed on migration and invasion of 4T1 were detected. The expression of EMT-related markers was detected by Western blot and qPCR. The 4T1 orthotopic murine breast cancer model was established to evaluate the therapeutic effect of Wed on the growth and metastasis of breast cancer through TGF-β1/Smad pathway.

Results
Wed inhibited the proliferation, migration and invasion of 4T1. It exhibited concentration-dependent inhibition of p-Smad2/3. Wed also reversed the expression of EMT-markers induced by TGF-β1. In addition, Wed suppressed the growth and metastasis of breast cancer in mice. It also affected p-Smad3 expression as well as EMT-related genes, suggesting that its anti-breast cancer effect may be related to the TGF-β1/Smad pathway.

Conclusion
Wed reverses EMT by regulating TGF-β1/Smad pathway, potentially serving as a therapeutic agent for breast cancer. Wed is expected to be a potential drug to inhibit TGF-β1/Smad pathway-related diseases.
The language politics of uncertainty: On the temporal consequences of Germany’s newcomer integration policy
Authors: Schulte Leonie 
Published: June 2024

Abstract
This paper examines the temporal consequences of Germany’s language-and-integration measures for adult migrants and refugees. In response to over 1.3 million displaced persons seeking asylum in Europe since 2015, many countries have tightened their existing language learning requirements for newcomers as part of stricter immigration control. Germany has been at the forefront of these policy reforms, expanding its integration programmes to accelerate newcomer incorporation. Based on over 15 months of ethnographic fieldwork in Berlin, this paper shows that instead of accelerating access to employment and higher education, in practice, integration policies delay socioeconomic mobility among refugees and migrants. This is largely because language becomes embedded in a broader ideological and bureaucratic complex newcomers must negotiate in their recurrent interactions with state institutions. As I demonstrate, in part because of the slowing effect such policies have on their mobility, newcomers’ first few years in Germany are experienced as a period of protracted uncertainty.
Semantic precision: crafting RDF-based digital editions for unveiling the layers of historical correspondence
Authors: Alassi Sepideh , Rosenthaler Lukas 
Published: June 2024

Abstract
This article proposes that Resource Description Framework (RDF) technology is well suited for representing and storing inherently connected epistolary data. We justify this proposition by creating an RDF-based digital edition of the correspondence of members of the Bernoulli dynasty and Leonhard Euler and depicting the benefits this type of edition provides, which are hardly achievable otherwise. We describe the ontologies defined to fully represent letters and illustrate how we formulated letters’ historical, scientific content, rich with mathematical formulae, markups, figures, and references, as RDF statements to facilitate complex queries common in the humanities field. Next, we outline the tools we developed for presenting these editions in an efficient and user-friendly form, hiding the complexity of the data structure from non-technical users while offering sophisticated analysis features to explore atoms of knowledge and their relations. Additionally, since the citability and durability of the studied digital sources play a crucial role for scholars who publish research on the editions, we explain the steps we undertook to ensure the sustainability of the RDF-based editions and to offer persistent citation possibility.
BEBOP V. Homogeneous stellar analysis of potential circumbinary planet hosts
Authors: Freckelton Alix V , Sebastian Daniel , Mortier Annelies , Triaud Amaury H M J , Maxted Pierre F L , Acuña Lorena , Armstrong David J , Battley Matthew P , Baycroft Thomas A , Boisse Isabelle , Bourrier Vincent , Carmona Andres , Coleman Gavin A L , Cameron Andrew Collier , Cortés-Zuleta Pía , Delfosse Xavier , Dransfield Georgina , Duck Alison , Forveille Thierry , French Jenni R , Hara Nathan , Heidari Neda , Hellier Coel , Kunovac Vedad , Martin David V , Martioli Eder , McCormac James J , Nelson Richard P , Sairam Lalitha , Sousa Sérgio G , Standing Matthew R , Willett Emma 
Published: June 2024

ABSTRACT
Planets orbiting binary systems are relatively unexplored compared to those around single stars. Detections of circumbinary planets and planetary systems offer a first detailed view into our understanding of circumbinary planet formation and dynamical evolution. The BEBOP (binaries escorted by orbiting planets) radial velocity survey plays a special role in this adventure as it focuses on eclipsing single-lined binaries with an FGK dwarf primary and M dwarf secondary allowing for the highest radial velocity precision using the HARPS and SOPHIE spectrographs. We obtained 4512 high-resolution spectra for the 179 targets in the BEBOP survey which we used to derive the stellar atmospheric parameters using both equivalent widths and spectral synthesis. We furthermore derive stellar masses, radii, and ages for all targets. With this work, we present the first homogeneous catalogue of precise stellar parameters for these eclipsing single-lined binaries.
Supporting Music Therapy Majors with Mental Health Conditions
Authors: Gooding Lori F , Ferrer Alejandra J 
Published: June 2024

Abstract
While college students are developing the abilities needed to navigate adulthood, they also face risks including psychosocial stressors, substance use, and sleep disruption. Students with mental health conditions may face additional challenges that can leave them feeling overwhelmed, anxious, lonely and exhausted, and result in poor academic outcomes, including dropping out of school. Music therapy majors, like other music or health professions majors, may be at greater risk for experiencing mental health conditions due to heavy course loads, pressure to succeed, and other factors. Thus, it is vital that institutions implement strategies to support the mental health of their students. We propose that music therapy programs take both general and targeted approaches to support the mental health and well-being of music therapy students. This includes recognizing the challenges students with mental health conditions may face during preprofessional field experiences and implementing the use of general and targeted supports tailored to meet individual needs. In this article, we discuss a range of proactive strategies that can be implemented by faculty and related staff to support the health, well-being, and success of music therapy (or other music) majors with mental health conditions. It is our hope that the information provided will help faculty create a safe atmosphere that supports positive outcomes for students.
Evaluation of a Regional Tobacco Control Program (Greater Manchester’s Making Smoking History) on Quitting and Smoking in England 2014–2022: A Time-Series Analysis
Authors: Jackson Sarah E , Beard Emma , Brown Jamie 
Published: June 2024

Abstract

Introduction
This study aimed to assess the impact of Greater Manchester’s Making Smoking History program—a region-wide smoking cessation programs launched in January 2018—on key smoking and quitting outcomes.

Methods
Data were from a nationally representative monthly survey, 2014-2022 (n = 171 281). We used interrupted time-series analyses (Autoregressive Integrated Moving Average [ARIMA] and generalized additive models [GAM]) to examine regional differences between Greater Manchester and the rest of England, before and during the program’s first five years. Outcomes were rates of quit attempts and overall quits among smokers, quit success rates among smokers who tried to quit (preregistered outcomes), and current smoking prevalence among adults (unregistered outcome).

Results
Results showed mixed effects of the program on quitting. Primary ARIMA models showed comparative reductions in quit success rates (change in quarterly difference between regions = –11.03%; 95% CI –18.96; –3.11) and overall quit rates in Greater Manchester compared with the rest of England (–2.56%; 95% CI –4.95; –0.18), and no significant change in the difference in the quit attempt rate (+2.95%; 95% CI –11.64; 17.54). These results were not consistently observed across sensitivity analyses or GAM analyses. Exploratory ARIMA models consistently showed smoking prevalence in Greater Manchester declined more quickly than in the rest of England following the initiation of the program (–2.14%; 95% CI –4.02; –0.27).

Conclusions
The first five years of Greater Manchester’s Making Smoking History program did not appear to be associated with substantial increases in quitting activity. However, exploratory analyses showed a significant reduction in the regional smoking rate, over and above changes in the rest of England over the same period.

Implications
Taken together, these results show a relative decline in smoking prevalence in Greater Manchester but equivocal data on quitting, introducing some uncertainty. It is possible the program has reduced smoking prevalence in the absence of any substantial change in quitting activity by changing norms around smoking and reducing uptake, or by reducing the rate of late relapse. It is also possible that an undetected effect on quitting outcomes has still contributed to the program’s impact on reducing prevalence to some degree. It will be important to evaluate the overall impact of the program over a longer timeframe.
Small translocations of endangered Gallinula galeata sandvicensis (Hawaiian Common Gallinule) may be sufficient to generate a viable reintroduced population
Authors: van Rees Charles B , Reed J Michael 
Published: June 2024

Abstract
Where stable source populations of at-risk species exist, translocation may be a reasonable strategy for re-establishing extirpated populations. However, the success rates of such efforts are mixed, necessitating thorough preliminary investigation. Stochastic population modeling can be a useful method of assessing the potential success of translocations. Here, we report on the results of modeling translocation success for the Gallinula galeata sandvicensis or ‘alae ‘ula (Hawaiian Common Gallinule), an endangered waterbird endemic to the Hawaiian Islands. Using updated vital rates, we constructed a model simulating 3 existing extant (wild) source populations and a hypothetical recipient site on another island. We then projected the effects of 6 different translocation scenarios and sensitivity of the results to variation of three important demographic parameters on the probability of extinction (PE) of the reintroduced and donor populations. Larger translocations, of at least 30 birds, had low probability of extinction in the reintroduced population, but raised extinction risk of the smallest source population. Spacing out translocations in time (e.g., 10 birds translocated in total in 3 installments over 9 years), led to lower PE than translocating all individuals at once (i.e., bulk translocations) for both the source and reintroduced populations. Brood size and hatch-year juvenile survival had a disproportionate impact on reintroduced population viability. Importantly, the reported juvenile survival rate is very near the threshold for population failure. This suggests that post-introduction and subsequent management of wetlands, particularly predator control, could be critical to reintroduction success. We recommend that individuals should be translocated from multiple, genetically distinct subpopulations to reduce the possibility of inbreeding depression. Based on this analysis, the recipient wetland should be sufficiently large that it can support at least 25 pairs of gallinules. Based on recent estimates of population densities on O‘ahu, such a wetland would need to be between 3.75 and 74.6 ha.
Early interferon lambda production is induced by double-stranded RNA in iPS-derived hepatocyte-like cells
Authors: Sularea Vasile Mihai , Sharma Ruchi , Hay David C , O’Farrelly Cliona 
Published: June 2024

Abstract
Hepatotropic viruses are amongst the most ubiquitous pathogens worldwide, causing significant morbidity and mortality. As hepatocytes are among the primary targets of these viruses, their ability to mount early effective innate defence responses is of major research interest. Interferon lambda (IFNL) is produced early in response to viral stimulation in other cell types, but hepatocyte production of this interferon is little investigated. Due to the difficulty and significant costs in obtaining and culturing human primary hepatocytes, surrogate systems are widely sought. Here we used induced pluripotent stem (iPS)-derived hepatocyte-like cells (HLCs) to investigate hepatic IFNL expression in response to viral-like ligands. We demonstrate that hepatocytes rely on cytoplasmic pattern recognition receptors (PRRs) such as Protein Kinase RNA-dependent (PKR) and retinoic acid-inducible gene-I (RIG-I)-like receptors (RLR) for the detection of double stranded RNA. Stimulation of HLCs by viral-like RNA ligands activating cytosolic RNA sensors resulted in thousand fold increase of type III interferon gene expression. These results are in contrast with type I IFN expression, which was induced to a lower extent. Concomitant induction of interferon stimulated genes, such as interferon-stimulated gene 15 (ISG15) and CXCL10, indicated the ability of HLCs to activate interferon-dependent activity. These results demonstrate that HLCs mount an innate antiviral response upon stimulation with viral-like RNA characterized by the induction of type III IFN.
Optimal phenology of life history events in Calanus finmarchicus: exit from diapause in relation to interannual variation in spring bloom timing and predation
Authors: Anderson Thomas R , Hessen Dag O , Gentleman Wendy C , Yool Andrew , Mayor Daniel J 
Published: June 2024

Abstract
Respiration of lipids by copepods during diapause (overwintering dormancy) contributes to ocean carbon sequestration via the seasonal lipid pump (SLP). Parameterizing this flux in predictive models requires a mechanistic understanding of how life history adaptation in copepods shapes their timing of exit from diapause. We investigate the optimal phenology of Calanus finmarchicus in the Norwegian Sea using an individual-based model in which diapause exit is represented as a trait characterized by phenotypic mean and variance. Without interannual variability, optimal exit correlated with the onset of the spring phytoplankton bloom and phenotypic variance was of no benefit. In contrast, copepods endured reduced fitness and adopted bet-hedging strategies when exposed to interannual variability in bloom timing and predation: later exit from diapause and phenotypic variance maintained adult numbers in anomalous late-bloom years. Exit nevertheless remained well before the peak of the bloom which is a favorable strategy when low predation early in the year enhances survival of eggs and early developmental stages. Our work highlights the complex interactions between C. finmarchicus and its environment and the need for improved understanding of bet-hedging strategies and the cues of diapause exit to progress the representation of the SLP in global biogeochemical models.