bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arthroscopy on Anticoagulated Patients: A Retrospective Evaluation of Postoperative Complications
Authors: Flanigan David C. , Muchow Ryan , Orwin John , Graf Ben 
Published: March 2010

Anticoagulation is commonly needed for multiple medical conditions. The indications to discontinue anticoagulation for a simple procedure are controversial. Other surgical subspecialties have shown that keeping patients on warfarin during a simple procedure is safe. The purpose of this retrospective study was to evaluate the postoperative complications encountered for patients undergoing simple arthroscopic procedures while on warfarin. We hypothesized that anticoagulated patients undergoing simple arthroscopic procedures would have few surgical bleeding complications.
Arthroscopic procedures performed over a 10-year period on warfarin-anticoagulated patients were retrospectively evaluated. Data collected included the procedure and orthopedic problem, the type of anesthesia, the medical condition requiring anticoagulation, the international normalized ratio (INR) at surgery, and all postoperative complications (bleeding, hematoma, delayed healing, prolonged postoperative course, infection, and medical complication). Twenty-four patients met the inclusion criteria. All had abnormal INR levels at time of surgery. Four patients were operated on emergently for septic joints, and 20 patients had elective arthroscopic procedures (10 knees, 10 shoulders). There were no major intraoperative bleeding problems. Seven patients had minor postoperative surgical complications: 2 prolonged effusions and 5 prolonged ecchymosis. No medical complications were seen. Oral warfarin appeared to be a safe alternative to manipulating anticoagulation during the preoperative period for simple arthroscopic procedures. Minor bleeding complications consisting of ecchymosis were seen, but no medical complications were identified.
Stringent Patient Selection in Bulk Allograft Reconstructions
Authors: Cummings Judd , Villanueva Erland , Cearley David , Jones Kevin B. , Randall R. Lor 
Published: March 2010

We hypothesized that stringent patient selection in the use of large bulk structural allografts for limb preservation would positively affect outcomes and decrease complication rates by eliminating certain comorbid or social factors known to contribute to the most detrimental sources of allograft failure: infection, fracture, and nonunion.
Our selection criteria included patients who were younger than 50 years, nonsmokers, non-obese (body mass index <40), who did not receive radiation therapy to the recipient site perioperatively, and who underwent intercalary allograft reconstruction except in the upper extremity where osteoarticular allografts were permitted. Outcomes were assessed using the Musculoskeletal Tumor Society (MSTS) and Toronto Extremity Salvage Score (TESS) scoring systems. Twenty-three patients fulfilled our cohort inclusion criteria. The overall survival rate for the 23 allografts was 91% (21/23). Average MSTS and TESS scores were 76% and 87%, respectively. Eleven of 23 patients experienced at least 1 complication requiring a second procedure. Musculoskeletal Tumor Society scores among patients experiencing no complications averaged 83% vs 71% for patients experiencing at least 1 complication. Average TESS scores were 89% and 86%, respectively.
The results of our early experience indicate there is no appreciable difference in complication rates among our series of patients stringently selected for bulk allograft reconstruction compared to other previously reported studies.
Pain Control After Total Knee Arthroplasty: A Prospective Study Comparing Local Infiltration Anesthesia and Epidural Anesthesia
Authors: Thorsell Martin , Holst Petter , Hyldahl Hans Christian , Weidenhielm Lars 
Published: March 2010

Postoperative pain control after total knee arthroplasty (TKA) is a well-known clinical problem. Efforts to treat it with the use of local anesthesia have been made, but the results have been contradictive. In the late 1990s, an infiltrated solution of ropivacaine/ketorolac/adrenaline was shown to be effective for this purpose, and this technique has since spread over the world. The purpose of this study was to compare the local infiltration anesthesia technique with epidural anesthesia, which has been the most widely used technique in Sweden.
Eighty-five patients received either local infiltration anesthesia or epidural anesthesia for postoperative pain relief. Postoperative morphine consumption, range of motion, walking ability, patient satisfaction, hospital stay, and time in the recovery room were measured. The groups were followed equally. The patients in the local infiltration anesthesia group were mobilized 24 hours earlier. On postoperative day one, 22 of 33 patients in the local infiltration anesthesia group could get in and out of bed without assistance. Only 1 of 31 patients in the epidural anesthesia group could manage this. On postoperative day two, 28 of 33 patients in the local infiltration anesthesia group could walk without assistance, compared to 5 of 31 in the epidural anesthesia group. Seventy-six percent of the local infiltration anesthesia patients were “very satisfied” with their postoperative pain control method, compared to 40% of the epidural anesthesia patients.
The local infiltration anesthesia technique is better for postoperative pain relief in TKA than epidural anesthesia. It offers equal pain relief, faster mobilization, and more satisfied patients. No negative side effects were seen during the study.
Evaluation of Biomechanical and Histological Features of Vertebrae Following Vertebroplasty Using Hydroxyapatite Blocks
Authors: Oshima Masashi , Matsuzaki Hiromi , Tokuhashi Yasuaki , Okawa Akihiro 
Published: March 2010

Vertebroplasty was performed using hydroxyapatite blocks to examine the course of compressive strength and histological features in a dog model. The vertebral fracture model was prepared by punching a hole in the center of the vertebra and at 4 sites around the vertebra (5 holes in total) from the front side of the vertebra using an air drill and hollowing the holes. Measurements were made on healthy vertebrae, vertebrae from the vertebral fracture model, vertebrae removed from animals immediately after vertebroplasty, vertebrae collected 1 and 2 months after vertebroplasty, and vertebrae untreated for 1 month after vertebral fracture. Histological examinations were also performed 1 and 2 weeks and 1 and 2 months after vertebroplasty with hydroxyapatite blocks. The strength of vertebrae in the fracture model immediately after vertebroplasty was significantly higher than that in the untreated fracture, and the strength of vertebrae 1 month after the procedure was equivalent to that of healthy vertebrae. Histologically, new bone formation was found around hydroxyapatite blocks 2 weeks after the procedure, and strong crosslinking between neighboring hydroxyapatite blocks was found after 1 month.
These results suggest that hydroxyapatite blocks may be effective as filling material for vertebral fracture from both biomechanical and histological perspectives.
Intramedullary Bone Fragment Obstructing Passage of Reaming Guide Wire With Iatrogenic Fractured Tibia
Authors: Nag Suman , Lall Hitesh , Jain Vijay Kumar , Bansal Pankaj , Khare Rahul , Mittal Deepak 
Published: March 2010

Reamed interlocking intramedullary fixation is the treatment of choice for displaced tibial shaft fractures in adults. In most cases it can be performed without difficulty; however, technical difficulties may be encountered during nailing in some cases. This article describes a case of closed nailing for a tibial shaft fracture in which intramedullary guide wire was obstructed by a small intramedullary bone fragment in the distal fracture segment. Forceful reaming and insertion of the nail led to a break in the cortex of the distal fragment and bending of guide wire. Finally, open reduction and intramedullary nailing was performed to retrieve the guide wire and intramedullary bone fragment and fix the tibia.
A comminuted fracture with multiple close fragments in proximity to the fracture site should be preoperatively scrutinized to look for intramedullary bone fragment or a fragment that could be pushed in the intramedullary canal during the intramedullary nailing. The surgeon can then anticipate the potential operative difficulty that may be encountered during closed nailing of such a fracture; and the patient can be counseled, as open nailing is a safer and viable option. Finally it is pertinent that even if this fracture type is overlooked, catastrophe can be avoided by properly following all the steps of intramedullary nailing.
Chronic Closed Talus Dislocation: A Rare Presentation and Treatment Dilemma
Authors: Naranje Sameer , Mittal Ravi 
Published: March 2010

A chronic presentation of closed dorsolateral dislocation of the talus is a rare injury. A 35-year-old woman presented with pain and deformity of the right foot of 6 months' duration. Her medical history was significant for rheumatoid arthritis, for which she was being treated with steroids. Radiographs and computed tomography of the right foot showed dorsolateral talar dislocation with fracture of the medial malleolus. Dislocation of the talus from the tibiotalar, talocalcaneal, and talonavicular joints was indicative of talus dislocation with a fracture of the medial malleolus rather than a fracture-dislocation of the ankle joint. Because of chronic presentation of the injury and an inability to reduce this talus dislocation by closed methods, open total talectomy was performed. At 2-year follow-up, the patient had an AOFAS score of 78. The patient had an obvious limp on the affected limb but managed her activities of daily living well without a shoe raise or brace. Because of the severe varus inversion deformity of the foot preoperatively, the patient was not able to walk. Postoperatively, the deformity was corrected and the patient was able to stand and walk; she was satisfied with the outcome of the surgery.
To our knowledge, this is the first report of chronic closed dorsolateral talus dislocation. We recommend that chronic closed isolated dorsolateral talus dislocation can be effectively managed by total talectomy.
Nonoperative Biological Treatment Approach for Partial Achilles Tendon Lesion
Authors: Filardo Giuseppe , Presti Mirco Lo , Kon Elizaveta , Marcacci Maurilio 
Published: March 2010

Tendon injuries, especially those of the Achilles tendon, are major concerns in sports medicine. The clinical presentation can be acute or chronic and the pathologic findings can range from peritendonitis to full-thickness tendon rupture. Nonsurgical treatment is not always successful; in particular, significant partial ruptures seem to respond poorly to conservative measures and do not improve with time. Surgery is most often considered the favored treatment option for this kind of lesion to obtain pain relief and full functionality with long-standing effects.
This article describes a case of a partial tear of the Achilles tendon in a 34-year-old competitive athlete where surgical treatment was avoided in favor of a new biological approach. We applied autologous platelet growth factors through multiple platelet-rich plasma injections; approximately 6.5 billion platelets were injected into the lesion 3 times, 7 days apart. The treatment with platelet-rich plasma and a progressive rehabilitation program allowed the patient to play for 20 minutes in a basketball game 64 days after the trauma and in a full game 75 days after the trauma. To date, 18 months later, he has participated regularly in all the season's games and received no further treatment for his tendon.
The fast tissue repair, confirmed by magnetic resonance and ultrasound imaging, allowed a swift return to full functionality and competitive sports activity, suggesting a possible role of platelet growth factors in promoting rapid tendon healing with high-quality tissue. This biological approach may represent a less-invasive therapeutic option even in cases where severe tendon lesions are candidates for surgical treatment.
Primary mitochondrial disorders and mimics: Insights from a large French cohort
Authors: Rouzier Cécile , Pion Emmanuelle , Chaussenot Annabelle , Bris Céline , Ait‐El‐Mkadem Saadi Samira , Desquiret‐Dumas Valérie , Gueguen Naïg , Fragaki Konstantina , Amati‐Bonneau Patrizia , Barcia Giulia , Gaignard Pauline , Steffann Julie , Pennisi Alessandra , Bonnefont Jean‐Paul , Lebigot Elise , Bannwarth Sylvie , Francou Bruno , Rucheton Benoit , Sternberg Damien , Martin‐Negrier Marie‐Laure , Trimouille Aurélien , Hardy Gaëlle , Allouche Stéphane , Acquaviva‐Bourdain Cécile , Pagan Cécile , Lebre Anne‐Sophie , Reynier Pascal , Cossee Mireille , Attarian Shahram , Paquis‐Flucklinger Véronique ,   MitoDiag's Network Collaborators, Procaccio Vincent 
Published: May 2024

AbstractObjectiveThe objective of this study was to evaluate the implementation of NGS within the French mitochondrial network, MitoDiag, from targeted gene panels to whole exome sequencing (WES) or whole genome sequencing (WGS) focusing on mitochondrial nuclear‐encoded genes.MethodsOver 2000 patients suspected of Primary Mitochondrial Diseases (PMD) were sequenced by either targeted gene panels, WES or WGS within MitoDiag. We described the clinical, biochemical, and molecular data of 397 genetically confirmed patients, comprising 294 children and 103 adults, carrying pathogenic or likely pathogenic variants in nuclear‐encoded genes.ResultsThe cohort exhibited a large genetic heterogeneity, with the identification of 172 distinct genes and 253 novel variants. Among children, a notable prevalence of pathogenic variants in genes associated with oxidative phosphorylation (OXPHOS) functions and mitochondrial translation was observed. In adults, pathogenic variants were primarily identified in genes linked to mtDNA maintenance. Additionally, a substantial proportion of patients (54% (42/78) and 48% (13/27) in children and adults, respectively), undergoing WES or WGS testing displayed PMD mimics, representing pathologies that clinically resemble mitochondrial diseases.InterpretationWe reported the largest French cohort of patients suspected of PMD with pathogenic variants in nuclear genes. We have emphasized the clinical complexity of PMD and the challenges associated with recognizing and distinguishing them from other pathologies, particularly neuromuscular disorders. We confirmed that WES/WGS, instead of panel approach, was more valuable to identify the genetic basis in patients with “possible” PMD and we provided a genetic testing flowchart to guide physicians in their diagnostic strategy.
Correlating Aggregation Ability of Polymer Donors with Film Formation Kinetics for Organic Solar Cells with Improved Efficiency and Processability
Authors: Qiu Dingding , Tian Chenyang , Zhang Hao , Zhang Jianqi , Wei Zhixiang , Lu Kun 
Published: May 2024

AbstractFilm formation kinetics significantly impact molecular processability and power conversion efficiency (PCE) of organic solar cells. Here, two ternary random copolymerization polymers are reported, D18─N‐p and D18─N‐m, to modulate the aggregation ability of D18 by introducing trifluoromethyl‐substituted pyridine unit at para‐ and meta‐positions, respectively. The introduction of pyridine unit significantly reduces material aggregation ability and adjusts the interactions with acceptor L8‐BO, thereby leading to largely changed film formation kinetics with earlier phase separation and longer film formation times, which enlarge fiber sizes in blend films and improve carrier generation and transport. As a result, D18─N‐p with moderate aggregation ability delivers a high PCE of 18.82% with L8‐BO, which is further improved to 19.45% via interface engineering. Despite the slightly inferior small area device performances, D18─N‐m shows improved solubility, which inspires to adjust the ratio of meta‐trifluoromethyl pyridine carefully and obtain a polymer donor D18─N‐m‐10 with good solubility in nonhalogenated solvent o‐xylene. High PCEs of 13.07% and 12.43% in 1 cm2 device and 43 cm2 module fabricated with slot‐die coating method are achieved based on D18─N‐m‐10:L8‐BO blends. This work emphasizes film formation kinetics optimization in device fabrication via aggregation ability modulation of polymer donors for efficient devices.
Freestanding Ammonium Vanadate Composite Cathodes with Lattice Self‐Regulation and Ion Exchange for Long‐Lasting Ca‐Ion Batteries
Authors: Wang Junjun , Zhang Yadi , Qiao Fan , Jiang Yalong , Yu Ruohan , Li Jiantao , Lee Sungsik , Dai Yuhang , Guo Fei , Jiang Peie , Zhang Lei , An Qinyou , He Guanjie , Mai Liqiang 
Published: May 2024

AbstractCalcium‐ion batteries (CIBs) have emerged as a promising alternative for electrochemical energy storage. The lack of high‐performance cathode materials severely limits the development of CIBs. Vanadium oxides are particularly attractive as cathode materials for CIBs, and preinsertion chemistry is often used to improve their calcium storage performance. However, the room temperature cycling lifespan of vanadium oxides in organic electrolytes still falls short of 1000 cycles. Here, based on preinsertion chemistry, the cycling life of vanadium oxides is further improved by integrated electrode and electrolyte engineering. Utilizing a tailored Ca electrolyte, the constructed freestanding (NH4)2V6O16·1.35H2O@graphene oxide@carbon nanotube (NHVO‐H@GO@CNT) composite cathode achieves a 305 mAh g−1 high capacity and 10 000 cycles record‐long life. Additionally, for the first time, a Ca‐ion hybrid capacitor full cell is assembled and delivers a capacity of 62.8 mAh g−1. The calcium storage mechanism of NHVO‐H@GO@CNT based on a two‐phase reaction and the exchange of NH4+ and Ca2+ during cycling are revealed. The lattice self‐regulation of V─O layers is observed and the layered vanadium oxides with Ca2+ pillars formed by ion exchange exhibit higher capacity. This work provides novel strategies to enhance the calcium storage performance of vanadium oxides via integrated structural design of electrodes and electrolyte modification.
Visible Light Induced Halogen Bond Assisted Friedel‐Crafts Reaction of Indole and Chalcones
Authors: Kumar Sunil , Das Anupam , Thomas K. R. Justin 
Published: May 2024

AbstractThe use of halogen bonding interactions as an alternative to acid and metal catalysts for substrate activation has gained popularity in recent years. In this work we demonstrate a halogen bond assisted activation of chalcones under visible light irradiation for the Friedel‐Crafts reaction with indole to yield β‐indolylketones. The simple and scalable protocol uses the readily available CBr4 as halogen bond catalyst. The targets are produced in 31–94% of yield with excellent functional group tolerance. The proposed mechanism of the reaction is supported by UV‐vis, fluorescence, and NMR spectroscopic studies. Further it is demonstrated that the β‐indolylketones can be oxidised to indole substituted α, β‐unsaturated ketones by DDQ or cyclized to thieno[2,3‐b]indoles in the presence of elemental sulfur and base.
Systematic Review of Air Pollution in Morocco: Status, Impacts, and Future Directions
Authors: Sekmoudi Imane , Tanarhte Meryem , Bouzghiba Houria , Khomsi Kenza , Idrissi Laila , El jarmouni Mohamed , Géczi Gábor 
Published: May 2024

AbstractDespite the recognition of the importance of air pollution in Morocco, current scientific studies are predominantly descriptive and limited. This systematic review aims to provide a comprehensive overview of air pollution in Morocco, delineating the research status and identifying gaps. Searches conducted across PubMed, Google Scholar, and Scopus from 2016 to May 2023 yielded over 3200 articles. From these, 64 original studies are deemed eligible and selected, focusing on air pollution in Moroccan regions or cities. Review articles and those dealing with indoor air quality are excluded, with no restriction on specific pollutant. Research highlights road traffic as the primary contributor to air pollution in Morocco, followed by industrial activities. Exposure to air pollutants is associated with adverse health effects, including mortality, lung disease, respiratory disorders, asthma attacks, and cardiovascular disease. Pollution levels vary among cities, with Casablanca, Kenitra, and Essaouira consistently facing higher pollution levels due to transportation and industrial emissions. Altitude also influences air quality, with higher‐altitude areas generally experiencing lower pollutant concentrations. The review highlights the need for extensive research on air pollution's health and economic effects, improved air quality modeling, and broader pollutant focus beyond just regulated ones.
Reconstructing Solvation Structure by Steric Hindrance‐Coordination Push‐Pull of Dipolymer‐H2O‐Zn2+ toward Long‐life Aqueous Zinc‐Metal Batteries
Authors: Luo Die , Ma Xinyu , Du Pan , Chen Zuo , Lin Qiurui , Liu Yuhan , Niu Ben , He Xianru , Wang Xin 
Published: May 2024

AbstractAqueous zinc‐metal batteries are prospective energy storge devices due to their intrinsically high safety and cost effectiveness. Yet, uneven deposition of zinc ions in electrochemical reduction and side reactions at the anode interface significantly hinder their development and application. Here, we propose a solvation‐interface attenuation strategy enabled by a frustrated tertiary amine amphiphilic dipolymer electrolyte additive. The configuration of superhydrophilic segments with covalently bonded lipophilic spacers enables coupled steric hindrance/coordination, which establishes a balanced push‐pull dynamic of dipolymer‐H2O‐Zn2+. Such interplay reconstructs the solvation structure of Zn2+ and allows the formation of a stable dipolymer‐inorganic hybrid solid electrolyte interface (SEI) layer. This SEI layer effectively shields the zinc‐metal anode from water and anions, significantly reducing side reactions. In addition, the dipolymer adsorbed at the zinc‐metal anode interface regulates the interfacial electrochemical reduction kinetics and ensures uniform zinc deposition. As a result, the Zn−Zn symmetric cells with dipolymer‐containing electrolyte exhibit remarkable cycling stability exceeding 5800 h (242 days). The Zn‐NVO batteries and Zn‐AC hybrid ion supercapacitors also deliver stable cycling for up to 1440 h (60 days) with high‐capacity retention over 80 %. This research demonstrates the potential to facilitate the development and commercialization of zinc‐based energy storage devices.
Reaction, Recognition, Relay: Anhydride Hydrolysis Reported by Conformationally Responsive Fluorinated Foldamers in Micelles
Authors: Doerner Benedicte , della Sala Flavio , Wang Siyuan , Webb Simon J. 
Published: May 2024

AbstractNatural membrane receptors are proteins that can report on changes in the concentration of external chemical messengers. Messenger binding to a receptor produces conformational changes that are relayed through the membrane into the cell; this information allows cells to adapt to changes in their environment. Artificial membrane receptors (R)‐1 and (S)‐1 are helical α‐aminoisobutyric acid (Aib) foldamers that replicate key parts of this information relay. Solution‐phase 19F NMR spectroscopy of zinc(II)‐capped receptor 1, either in organic solvent or in membrane‐mimetic micelles, showed messenger binding produced an enrichment of either left‐ or right‐handed screw‐sense; the chirality of the bound messenger was relayed to the other receptor terminus. Furthermore, in situ production of a chemical messenger in the external aqueous environment could be detected in real‐time by a racemic mixture of receptor 1 in micelles. The hydrolysis of insoluble anhydrides produced carboxylate in the aqueous phase, which bound to the receptors and gave a distinct 19F NMR output from inside the hydrophobic region of the micelles.