bluuebunny/crossref_metadata_2025_split huggingface dataset:
Young-onset dementia and MRI changes in a patient with subclinical liver cirrhosis due to chronic hepatitis C
Authors: Boban Marina , Malojčić Branko 
Published: December 2011

AbstractYoung-onset dementia (before age of 65) is relatively infrequent and presents a challenge in everyday neurological practice due to wide spectrum of clinical presentations and diversity of underlying etiology. When cognitive deficits are accompanied with liver dysfunction different etiologies should be considered. We present a case report of a young patient with subclinical decompensated liver disease due to underlying chronic hepatitis C, presented with the mildest form of hepatic encephalopathy spectrum, called minimal (subclinical) hepatic encephalopathy and characteristic MRI changes.
Combining Ability Analysis In Rice (<i>Oryza Sativa</i> L.)
Authors: Akter A , Hasan MJ , Begum H , Kulsum MU , Hossain MK 
Published: December 2011

Twenty hybrids were produced using five CMS lines viz., BRRI3A, BRRI9A, IR73328A, BRRI10A and IR78355A and four restorers viz., BRRI12R, BRRI13R, BRRI14R and BRRI15R following line x tester mating design to find out the best combination (s) in respect of their combining ability effects among the parents and hybrids at BRRI, Gazipur, Bangladesh from July 2008 to May 2009. Data were recorded from yield and yield contributing agronomic characters each entry through out the replications and mean values were subjected to line x tester analysis. The genotypes were found highly significant for all the traits which indicated that the treatments used in this study were significantly varied from each other. After the partitioning of mean sums of squares (MSS) of the treatments into parent, cross and parent vs cross. They were found highly significant except yield per plant for parent, panicle weight for crosses and leaf area index for parent vs cross. The ratio of GCA and SCA variances were found less than unity for all the characters except plant height, days to maturity and panicles per square meter. The relative contribution of line, tester and combinations of line x tester interaction of ten characters were calculated and found that panicle weight contributed the highest (69.53%) followed by thousand grain weight (63.62%), yield per plant (54.76%), panicle per meter square 51.52% in their hybrids. IR73328A was identified as good general combiner for shorter plant height (-6.09) and panicle per square meter (16.92). BRRI10A and IR78355A produced significant positive GCA for yield per plant which could be regarded as good general combiner for higher grain yield. Six hybrid combinations were found with significant and positive SCA effect of which the highest value was obtained from BRRI3A/BRRI14R (2.46) followed by IR73328A/BRRI13R (2.23) for yield per plant. Key words: Line × tester; GCA; SCA; riceDOI: http://dx.doi.org/10.3329/bjpbg.v23i2.9319 Bangladesh J. Pl. Breed. Genet., 23(2): 7-13, 2010
Multivariate Analysis Of Divergence In Advanced Lines Of Mustard (<i>Brassica spp</i>)
Authors: Zaman MA , Tuhina-Khatun M , Ullah MZ , Moniruzzamn M , Rahman MZ 
Published: December 2011

A field experiment was conducted comprising eighteen advanced lines of mustard in a randomized block design with three replication at Regional Agricultural Research Station, BARI, Hathazari, Chittagong during Rabi season (December 2009 to April 2010) for estimation of divergence among advanced lines of mustard. The genotypes were grouped into four clusters. Cluster I contained the highest number of genotypes (6) and the cluster III contained the lowest (3). The inter-cluster distances in all cases were larger than the intra-cluster distance which indicated that wider diversity was present among the genotypes of distant grouped. The highest intra cluster distance was observed in cluster II and the lowest in I. The highest inter cluster distance was observed between the cluster III and II followed by III and I and the lowest between cluster IV and III. Days to 50% flowering (81.94%), days to maturity (8.24%), plant height (5.82%), branches per plant (1.91%) and siliquae per plant (1.17%) contributed maximum towards the total divergence which suggested that these characters were highly responsible for genetic divergence in the present materials. But the highest cluster means for primary branches per plant and maximum seeds per siliquae with minimum seed yield per plant were obtained from the cluster II. The genotypes from cluster I had dwarf plant along with earliness in days to 50% flowering, days to maturity and maximum number of primary branches per plant. Therefore, the genotypes from cluster I and III could be utilized in the hybridization programme for getting desirable transgressive segregants and high heterotic response due to getting maximum yield along with short duration. Key words: Multivariate analysis; Divergence; MustardDOI: http://dx.doi.org/10.3329/bjpbg.v23i2.9322 Bangladesh J. Pl. Breed. Genet., 23(2): 29-34, 2010
Sistema de Inteligência Acadêmica na gestão da Pós-Graduação Stricto Sensu em Administração
Authors: Macedo Daniela Luiza , Rodrigues Leonel Cezar , Silveira Amelia 
Published: December 2011

O objetivo deste trabalho foi analisar a gestão de dois Programas de Pós-Graduação Stricto Sensu em Administração (PPGSSAs) buscando contribuir com proposições para a implantação de um SIAc, como apoio aos processos decisórios e à formulação de estratégias nos Programas pesquisados. Os PPGSSAs selecionados estão vinculados a Instituições de Ensino Superior (IES), uma pública e outra privada, tendo sido selecionados de forma intencional em razão de critérios de qualidade. O referencial teórico envolveu, principalmente, a literatura sobre Inteligência Competitiva (IC) e suas interfaces com a formulação de estratégias. A pesquisa foi empírica, exploratória, com método qualitativo, e de estudo de casos múltiplos. Os resultados indicam que em ambos os Programas há indícios de utilização de Inteligência Acadêmica (IA), ainda que de forma simplificada e orientada para responder aos requisitos de qualidade indicados pela CAPES. A análise permitiu apontar o papel e as funções para um SIAc, dentro da estrutura administrativa e operacional dos programas estudados, onde este suporta e aperfeiçoa a formulação de estratégias para a melhoria da qualidade, com aumento da visibilidade e da inserção social dos dois programas, objeto de análise. Há compreensão e entendimento da oportunidade da adoção de um SIAc nos PPGSSAs pelos gestores, líderes de linha de pesquisa e especialistas técnicos participantes da pesquisa.
Ethical Issues Raised in Addressing the Needs of People With Serious Mental Disorders in Complex Emergencies
Authors: Wissow Lawrence S. , Rutkow Lainie , Kass Nancy E. , Rabins Peter V. , Vernick Jon S. , Hodge James G. 
Published: January 2012

ABSTRACTRecent manmade and natural disasters highlight weaknesses in the public health systems designed to protect populations from harm and minimize disruption of the social and built environments. Emergency planning and response efforts have, as a result, focused largely on ensuring populations' physical well-being during and after a disaster. Many public health authorities, including the World Health Organization, have recognized the importance of addressing both mental and physical health concerns in emergency plans. Individuals with mental disorders represent a notable proportion of the overall population, and anticipating their needs is critical to comprehensive emergency planning and response efforts. Because people with serious mental disorders historically have been stigmatized, and many individuals with mental disorders may be unable to care for themselves, ethical guidance may be of assistance to those engaged in emergency planning and response. This article considers several broad categories of ethical issues that arise during emergencies for people with serious mental disorders and offers recommendations for ways in which emergency planners and other stakeholders can begin to address these ethical challenges.(Disaster Med Public Health Preparedness. 2012;6:72–78)
Toe‐out, lateral trunk lean, and pelvic obliquity during prolonged walking in patients with medial compartment knee osteoarthritis and healthy controls
Authors: Bechard Daniel J. , Birmingham Trevor B. , Zecevic Aleksandra A. , Jones Ian C. , Giffin J. Robert , Jenkyn Thomas R. 
Published: December 2011

AbstractObjectiveTo compare the time‐varying behavior of maximum toe‐out angle, lateral trunk lean (over the stance leg), and pelvic obliquity (rise and drop on the swing leg) during prolonged walking in participants with and without medial compartment knee osteoarthritis (OA), and to explore correlations between these gait characteristics and pain.MethodsTwenty patients with knee OA and 20 healthy controls completed 30 minutes of treadmill walking. Toe‐out, trunk lean, pelvic obliquity, and pain were measured at 5‐minute intervals.ResultsThe mean ± SD toe‐out angle was significantly smaller (P = 0.04) in patients with knee OA (6.7 ± 2.5 degrees) than in controls (10.3 ± 2.2 degrees). Toe‐out changed significantly over time (P = 0.002), but not in a systematic way, and there was no interaction between group and time. The mean ± SD trunk lean was higher (P = 0.03) in patients with knee OA (2.0 ± 1.0 degrees) than in controls (0.7 ± 0.5 degrees). Trunk lean did not change over time and there was no interaction between group and time. There were no differences for pelvic drop. The mean ± SD pelvic rise was higher (P = 0.01) in patients with knee OA (2.8 ± 0.9 degrees) than in controls (1.2 ± 0.8 degrees), but did not change over time and there was no interaction. Patients experienced a small increase in pain (P < 0.001). Trunk lean and pelvic drop were correlated with pain (r = 0.49, P = 0.03 and r = 0.47, P = 0.04, respectively).ConclusionToe‐out and trunk lean are consistently different between individuals with and without medial compartment knee OA during prolonged walking, and patients with greater pain have greater trunk lean. However, over 30 minutes of walking, these gait characteristics remain quite stable, suggesting they are not acute compensatory mechanisms in response to repetitive loading with subtle increases in pain.
Performance of automated and manual coding systems for occupational data: A case study of historical records
Authors: Patel Mehul D. , Rose Kathryn M. , Owens Cindy R. , Bang Heejung , Kaufman Jay S. 
Published: December 2011

AbstractBackgroundOccupational data are a common source of workplace exposure and socioeconomic information in epidemiologic research. We compared the performance of two occupation coding methods, an automated software and a manual coder, using occupation and industry titles from U.S. historical records.MethodsWe collected parental occupational data from 1920–40s birth certificates, Census records, and city directories on 3,135 deceased individuals in the Atherosclerosis Risk in Communities (ARIC) study. Unique occupation‐industry narratives were assigned codes by a manual coder and the Standardized Occupation and Industry Coding software program. We calculated agreement between coding methods of classification into major Census occupational groups.ResultsAutomated coding software assigned codes to 71% of occupations and 76% of industries. Of this subset coded by software, 73% of occupation codes and 69% of industry codes matched between automated and manual coding. For major occupational groups, agreement improved to 89% (kappa = 0.86).ConclusionsAutomated occupational coding is a cost‐efficient alternative to manual coding. However, some manual coding is required to code incomplete information. We found substantial variability between coders in the assignment of occupations although not as large for major groups. Am. J. Ind. Med. 55:228–231, 2012. © 2011 Wiley Periodicals, Inc.
Mutations in MECP2 exon 1 in classical rett patients disrupt MECP2_e1 transcription, but not transcription of MECP2_e2
Authors: Gianakopoulos Peter J. , Zhang Yuzhi , Pencea Nela , Orlic‐Milacic Marija , Mittal Kirti , Windpassinger Christian , White Sara‐Jane , Kroisel Peter M. , Chow Eva W.C. , Saunders Carol J. , Minassian Berge A. , Vincent John B. 
Published: December 2011

AbstractThe overwhelming majority of Rett syndrome cases are caused by mutations in the gene MECP2. MECP2 has two isoforms, termed MECP2_e1 and MECP2_e2, which differ in their N‐terminal amino acid sequences. A growing body of evidence has indicated that MECP2_e1 may be the etiologically relevant isoform in Rett Syndrome based on its expression profile in the brain and because, strikingly, no mutations have been discovered that affect MECP2_e2 exclusively. In this study we sought to characterize four classical Rett patients with mutations that putatively affect only the MECP2_e1 isoform. Our hypothesis was that the classical Rett phenotype seen here is the result of disrupted MECP2_e1 expression, but with MECP2_e2 expression unaltered. We used quantitative reverse transcriptase PCR to assay mRNA expression for each isoform independently, and used cytospinning methods to assay total MECP2 in peripheral blood lymphocytes (PBL). In the two Rett patients with identical 11 bp deletions within the coding portion of exon 1, MECP2_e2 levels were unaffected, whilst a significant reduction of MECP2_e1 levels was detected. In two Rett patients harboring mutations in the exon 1 start codon, MECP2_e1 and MECP2_e2 mRNA amounts were unaffected. In summary, we have shown that patients with exon 1 mutations transcribe normal levels of MECP2_e2 mRNA, and most PBL are positive for MeCP2 protein, despite them theoretically being unable to produce the MECP2_e1 isoform, and yet still exhibit the classical RTT phenotype. Altogether, our work further supports our hypothesis that MECP2_e1 is the predominant isoform involved in the neuropathology of Rett syndrome. © 2011 Wiley Periodicals, Inc.
A study on the distinguishing responses of shrinkage and warpage to processing conditions in injection molding
Authors: Liu Fen , Zeng Shengqu , Zhou Huamin , Li Jianhui 
Published: December 2011

AbstractA challenging task in injection molding industry is to minimize shrinkage and warpage (S&W) through optimal setting of molding conditions. In determining the relationship between molding conditions and product dimension, most existing literature considered S&W as a whole entity or focused on only one of them. The intention of this study was to distinguish these two terms, and perform a thorough analysis on the effect of operative conditions on S&W during injection molding process through a combination of experimental and numerical methods. Six process parameters with five levels were examined on a box‐shaped product, and the single factor analysis of variance (ANOVA) was adopted in identifying the significance of each variable in the experiment. Results indicated that the effect of processing conditions on shrinkage is different from that on warpage. Specifically, packing pressure affects shrinkage most while packing time is the dominant factor in determining warpage. The reaction of shrinkage to packing pressure is monotonic, whereas the plot of warpage shows a U‐shaped variation. A differential treatment of S&W can therefore help to enhance product quality. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Synthesis and characterization of α,ω‐Bis(3‐hydroxypropyl)‐functionalized poly{dimethylsiloxane‐co‐methyl[3‐(2‐acetyl‐acetoxy)]propylsiloxane}
Authors: Zhang Meng , Wu Yuanjuan , Wu Haiyan , Zhang Qingsi , Xia Yongmei 
Published: December 2011

AbstractWith the purpose to develop polysiloxane‐modified waterborne polyurethane (WPU) which was expected to have better water resistance than WPU and better mechanical strength and abrasion characteristics than polysiloxane, a novel reactive polysiloxane bearing hydroxypropyl group at both chain ends and carbonyl groups at the side chain was synthesized by five‐step reactions. The prepared compounds in each step were characterized; the results showed that each step synthesis was successfully carried out and objective products were achieved. This novel reactive polysiloxane combines the properties of difunctional hydroxyalkyl terminated polysiloxane and crosslinking agent. When it was incorporated with WPU, the latex film properties of reactive polysiloxane‐modified WPU were investigated compared with that of pure WPU. The results indicated that siloxane segments could lower the water absorption of WPU, and that the crosslinking reaction between the dihydrazide and carbonyl group could improve the physical–mechanical characteristics of polysiloxane‐modified WPU after post‐added dihydrazide. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Correlation of miscibility and mechanical properties of polypropylene/olefin block copolymers: Effect of chain composition
Authors: Liu Guoming , Zhang Xiuqin , Li Xiuhong , Chen Hongyu , Walton Kim , Wang Dujin 
Published: December 2011

AbstractThis study examines the miscibility and mechanical properties of isotactic polypropylene (iPP) and olefin block copolymer (OBC) blends (70/30 wt %). The blends exhibit phase‐separated morphology. The OBC domain size decreases with increasing the 1‐octene content in the soft segment. The crystallization, melting behavior, and the long spacing of the iPP component in the blends are nearly the same as those of neat iPP, while the Tg of the iPP component shifts slightly to lower temperature. “Blocky” OBC is immiscible with iPP, while the soft segment rich polymers in OBC could be partially miscible with iPP. The impact strength of the blends is greatly increased with increasing the 1‐octene content in the OBC soft segment. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Developmental Expression Pattern of Hspb8 mRNA in the Mouse Brain: Analysis Through Online Databases
Authors: García‐Lax Noelia , Tomás‐Roca Laura , Marín Faustino 
Published: December 2011

AbstractHspb8 is a member of the Hspb family of chaperone‐like proteins. It is involved in several neural disorders such as Alzheimer's disease, amyotrophic lateral sclerosis, hereditary distal motor neuropathy, and Charcot‐Marie‐Tooth's disease. In this work, we aimed to characterize its expression pattern in the mouse brain, by using the information available at online databases of high‐throughput in situ hybridization. Therefore, we downloaded and analyzed the image series from these databases showing Hspb8 mRNA expression from embryonic to adult and aging stages. In early gestational embryos, Hspb8 was expressed in the hippocampal anlagen and in the ventricular layer of rhombomere 4. At perinatal stages, there appeared transitory expression in the dentate gyrus and the cerebellar cortex. From perinatal to aging stages, the neurons of the mesencephalic trigeminal nucleus and cranial motor nuclei displayed stable and strong Hspb8 expression. Additionally, along these stages there was moderate and relatively homogenous expression in the anterodorsal thalamic, lateral mammillary, arcuate hypothalamic and medial habenular nuclei, and in the locus coeruleus. In its turn, the basal ganglia, cerebellar inner granular layer and diverse sensory and reticular formation nuclei of the hindbrain contained scattered cells with strong expression. In conclusion, Hspb8 mRNA is constitutively expressed in specific brain structures across ontogeny, so that eventually they could be affected by the malfunction or deregulation of this molecule. Anat Rec, 2012. © 2011 Wiley Periodicals, Inc.
Interleukin‐22 and interleukin‐22–producing NKp44+ natural killer cells in subclinical gut inflammation in ankylosing spondylitis
Authors: Ciccia Francesco , Accardo‐Palumbo Antonina , Alessandro Riccardo , Rizzo Aroldo , Principe Simona , Peralta Sergio , Raiata Francesca , Giardina AnnaRita , De Leo Giacomo , Triolo Giovanni 
Published: December 2011

AbstractObjectiveThe intestinal inflammation observed in patients with ankylosing spondylitis (AS) is characterized by an overexpression of interleukin‐23 (IL‐23). IL‐23 is known to regulate IL‐22 production through lamina propria NKp44+ natural killer (NK) cells, which are thought to be involved in protective mucosal mechanisms. This study was undertaken to evaluate the frequency of NKp44+ NK cells and the expression of IL‐22 in the ileum of AS patients.MethodsTissue NKp44+ NK cells, NKp46+ NK cells, and IL‐22–producing cells were analyzed by flow cytometry. Quantitative gene expression analysis of IL‐22, IL‐23, IL‐17, STAT‐3, and mucin 1 (MUC‐1) was performed by reverse transcriptase–polymerase chain reaction on ileal samples from 15 patients with AS, 15 patients with Crohn's disease (CD), and 15 healthy controls. NKp44, pSTAT‐3, and IL‐22 expression was analyzed by immunohistochemistry.ResultsThe frequency of NKp44+ but not NKp46+ NK cells was increased in the inflamed ileum of AS patients compared to CD patients and controls. The frequency of NKp46+ NK cells was significantly increased only in CD patients. Among CD4+ lymphocytes and NKp44+ NK cell subsets, the latter were the major source of IL‐22 on lamina propria mononuclear cells from AS patients. Significant up‐regulation of IL‐22, IL‐23p19, MUC‐1, and STAT‐3 transcripts in the terminal ileum of patients with AS was observed. Immunohistochemical analysis confirmed the increased IL‐22 and pSTAT‐3 expression in inflamed mucosa from AS and CD patients.ConclusionOur findings indicate that overexpression of IL‐22, together with an increased number of IL‐22–producing NKp44+ NK cells, occurs in the gut of AS patients, where it appears to play a tissue‐protective role.
Select host cell proteins coelute with monoclonal antibodies in protein a chromatography
Authors: Nogal Bartek , Chhiba Krishan , Emery Jefferson C. 
Published: December 2011

AbstractThe most significant factor contributing to the presence of host cell protein (HCP) impurities in Protein A chromatography eluates is their association with the product monoclonal antibodies (mAbs) has been reported previously, and it has been suggested that more efficacious column washes may be developed by targeting the disruption of the mAbs–HCP interaction. However, characterization of this interaction is not straight forward as it is likely to involve multiple proteins and/or types of interaction. This work is an attempt to begin to understand the contribution of HCP subpopulations and/or mAb interaction propensity to the variability in HCP levels in the Protein A eluate. We performed a flowthrough (FT) recycling study with product respiking using two antibody molecules of apparently different HCP interaction propensities. In each case, the ELISA assay showed depletion of select subpopulations of HCP in Protein A eluates in subsequent column runs, while the feedstock HCP in the FTs remained unchanged from its native harvested cell culture fluid (HCCF) levels. In a separate study, the final FT from each molecule's recycling study was cross‐spiked with various mAbs. In this case, Protein A eluate levels remained low for all but two molecules which were known as having high apparent HCP interaction propensity. The results of these studies suggest that mAbs may preferentially bind to select subsets of HCPs, and the degree of interaction and/or identity of the associated HCPs may vary depending on the mAb. © 2012 American Institute of Chemical Engineers Biotechnol. Prog., 2012