bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: {W48} Ring Opening: Fe16‐Containing, Ln4‐Stabilized 49‐Tungsto‐8‐Phosphate Open Wheel [Fe16O2(OH)23(H2O)9 (P8W49O189)Ln4 (H2O)20]11‐.
Authors: Ismail Amal H. , Bassil Bassem S. , Yassin Ghada H. , Keita Bineta , Kortz Ulrich 
Published: August 2012

AbstractK8.5Na0.5Li0.5Eu0.5 [P8W49O189Fe16O2 (OH)23(H2O)9Eu4(H 2O)20]·70H2O (I) and K9LiNa [P8W49O189Fe16O2 (OH)23(H2O)9 Gd4(H2O)20]·50H2 O (II) are synthesized from mixtures of FeCl3, EuCl3 or GdCl3, H2O2, and K28Li5 [H7P8W48O184] in a LiOC/AcOH solution (pH 4, 80°C, 1 h, 10% yield each).
ChemInform Abstract: Dilute Magnetic Semiconductor Cu2MnSnS4 Nanocrystals with a Novel Zincblende and Wurtzite Structure.
Authors: Liang Xiaolu , Guo Peng , Wang Gang , Deng Ruiping , Pan Daocheng , Wei Xianhua 
Published: August 2012

AbstractFor the first time, Cu2MnSnS4 nanocrystals with wurtzite and zincblende structure are synthesized by injecting an oleylamine solution of sulfur powder and thiourea, resp., into an oleylamine solution of Cu(OAc)2, SnCl4, and Mn(OAc)2 at 270 °C.
ChemInform Abstract: Easily Accessible Chiral Dicyclopentadiene Ligands for Rhodium‐Catalyzed Enantioselective 1,4‐Addition Reactions.
Authors: Shao Cheng , Yu Hong‐Jie , Feng Chen‐Guo , Wang Rui , Lin Guo‐Qiang 
Published: August 2012

AbstractA novel class of C1‐symmetric chiral diene ligands is developed, mainly by derivatization of parent CDL.
ChemInform Abstract: Aerobic Oxidation of Alcohols in the Liquid Phase with Nanoporous Gold Catalysts.
Authors: Asao Naoki , et al. et al. 
Published: August 2012

AbstractThe nanoporous Au‐catalyst, obtained by dealloying of Au30Ag70 alloy thin films with HNO3, is reusable multiple times without leaching and loss of activity.
ChemInform Abstract: TEMPO‐Mediated Oxidation of Alcohols with Ion‐Supported (Diacetoxyiodo)benzenes.
Authors: Suzuki Yusuke , Iinuma Masataka , Moriyama Katsuhiko , Togo Hideo 
Published: August 2012

AbstractEfficient ion‐supported reagents (I) and (II) are applied to the oxidation of various primary and secondary alcohols with similar efficiency.
ChemInform Abstract: From Olefination to Alkylation: In situ Halogenation of Julia—Kocienski Intermediates Leading to Formal Nucleophilic Iodo‐ and Bromodifluoromethylation of Carbonyl Compounds.
Authors: Zhao Yanchuan , Gao Bing , Hu Jinbo 
Published: August 2012

AbstractDifluoromethyl pyridyl sulfones and aldehydes or ketones undergo a base‐mediated rearrangement to give sulfinate intermediates which are iodinated or brominated to give the target CF2I‐ or CF2Br‐substituted compounds.
ChemInform Abstract: Electrogenerated Acetonitrile Anion Induced Selective N‐Alkylation of Bifunctional Compounds.
Authors: Feroci Marta , De Vita Daniela , Scipione Luigi , Sotgiu Giovanni , Tortorella Silvano 
Published: August 2012

AbstractGalvanostatic reduction of a solution of acetonitrile and Et4NPF6 generates an acetonitrile anion as selective reagent in the alkylation of bifunctional substrates with alkyl bromides.
ChemInform Abstract: Cobalt‐Catalyzed Arylation of Aldimines via Directed C—H Bond Functionalization: Addition of 2‐Arylpyridines and Self‐Coupling of Aromatic Aldimines.
Authors: Gao Ke , Yoshikai Naohiko 
Published: August 2012

AbstractIt is demonstrated that a polar C—N double bond can serve as a reaction partner for cobalt‐catalyzed C—H bond functionalization.
ChemInform Abstract: N‐(Phenylselenomethyl)phthalimide as New Reagent for Mild Protection of Alcohols as Pim‐Ethers.
Authors: Temperini Andrea , Minuti Lucio 
Published: August 2012

AbstractA mild procedure is developed for the activation of selenide (II) with iodonium ion and subsequent reaction with alcohols to afford the corresponding hemiaminal derivatives.
ChemInform Abstract: Kulinkovich‐Type Reactions of Thioamides: Similar to Those of Carboxylic Amides?
Authors: Augustowska Ewelina , Boiron Antoine , Deffit Jerome , Six Yvan 
Published: August 2012

AbstractTreatment of amides (V) and (VI) with Grignard reagents in the presence of titanium tetraisopropoxide leads to fused cyclopropane derivatives (III) and (VII), resp., while the analogous reaction of thioamide (I) gives rise to a mixture of aminocyclopropane derivative (III) and tertiary amines (IV).
ChemInform Abstract: Kinetic Resolution of 1‐(1‐Alkynyl)cyclopropyl Ketones by Gold(I)‐Catalyzed Asymmetric [4 + 3]Cycloaddition with Nitrones: Scope, Mechanism and Applications.
Authors: Zhang Yanqing , Zhang Junliang 
Published: August 2012

AbstractGold‐catalyzed asymmetric [4 + 3]‐cycloaddition reaction is applied for the kinetic resolution of different cyclopropyl ketones (IV).
ChemInform Abstract: A Direct Synthesis of Allenes by a Traceless Petasis Reaction.
Authors: Mundal Devon A. , Lutz Kelly E. , Thomson Regan J. 
Published: August 2012

AbstractThe coupling of hydroxyaldehydes or ketones with alkynyl trifluoroborate salts under conditions A) proceeds via sulfonylhydrazones and unstable propargylic hydrazide species which decompose to afford the allenes.
ChemInform Abstract: Oxidative Alkynylation of Imines with Alkynylcopper Reagents: A Straightforward and Practical Entry to Ynimines.
Authors: Laouiti Anouar , Jouvin Kevin , Bourdreux Flavien , Rammah Mohamed M. , Rammah Mohamed B. , Evano Gwilherm 
Published: August 2012

AbstractGenerally E/Z‐mixtures are obtained as products.
ChemInform Abstract: Gold Nanoparticles Supported on the Periodic Mesoporous Organosilicas as Efficient and Reusable Catalyst for Room Temperature Aerobic Oxidation of Alcohols.
Authors: Karimi Babak , Esfahani Farhad Kabiri 
Published: August 2012

AbstractGold nanoparticles are immobilized on a periodic mesoporous organosilica, formed by cocondensation of 1,2‐bis(triethoxysilyl)ethane with 1,4‐bis(triethoxysilyl)benzene and Pluronic P123 as structure directing agent.
ChemInform Abstract: Palladium‐Catalyzed Carbonylative Heck Reaction of Aryl Bromides with Vinyl Ethers to 3‐Alkoxy Alkenones and Pyrazoles.
Authors: Schranck Johannes , Wu Xiao‐Feng , Neumann Helfried , Beller Matthias 
Published: August 2012

AbstractThe novel method affords trans coupling products in all cases and proceeds in a highly regioselective manner.
ChemInform Abstract: Aerobic Oxidation of Propargylic Alcohols to α,β‐Unsaturated Alkynals or Alkynones Catalyzed by Fe(NO3)3·9H2O, TEMPO and Sodium Chloride in Toluene.
Authors: Liu Jinxian , Xie Xi , Ma Shengming 
Published: August 2012

AbstractA broad spectrum of target compounds is available in the presence of the catalytic system.
ChemInform Abstract: Direct Arylation of Benzene with Aryl Bromides Using High‐Temperature/High‐Pressure Process Windows: Expanding the Scope of C—H Activation Chemistry.
Authors: Pieber Bartholomaeus , Cantillo David , Kappe C. Oliver 
Published: August 2012

AbstractBy employing high‐throughput screening, a rapid determination of suitable catalyst/ligand/base combinations for the title reaction can be performed.
ChemInform Abstract: Diastereoselective Synthesis of γ‐Butenolides Catalyzed by Potassium tert‐Butoxide.
Authors: Du Guang‐Fen , He Lin , Gu Cheng‐Zhi , Dai Bin 
Published: August 2012

AbstracttBuOK catalyzes the vinylogous Mukaiyama aldol reaction between aldehydes and 2‐(trimethylsilyloxy)furan (I).
ChemInform Abstract: Hammet Constants Effects in Microwave Cascade Etherification—Cyclization—Krapcho Reaction to Access [2,3]‐Dihydrobenzofuran‐3‐ones from Salicylic Derivatives.
Authors: Farran Daniel , Bertrand Philippe 
Published: August 2012

AbstractThe title compounds (III) are synthesized from salicylate esters using microwave technology.
ChemInform Abstract: An Unusual and Chemoselective Reduction of Ester Grouping in N‐Substituted‐3‐acetylindoles by Sodium Borohydride.
Authors: Venkatanarayana Muvvala , Dubey Pramod K. 
Published: August 2012

AbstractNaBH4 reduction of compounds (I) proceeds with excellent chemoselectivity at the ester group to give N‐hydroxyethyl derivatives (II), leaving the keto group intact.
ChemInform Abstract: Facile Synthesis of Highly Functional Pyrrolizidine Derivatives from β,γ‐Unsaturated α‐Keto Esters and Proline via a Tandem Cycloaddition.
Authors: Kang Tai‐Ran , Cheng Yu , He Long , Ye Jia , Liu Quan‐Zhong 
Published: August 2012

AbstractAzomethine ylides generated in situ from α‐ketoesters and racemic proline undergo 1,3‐dipolar cycloaddition with further α‐keto ester to give diastereomerically pure title compounds.
ChemInform Abstract: Hydrazine‐Mediated Cyclization of Ugi Products to Synthesize Novel 3‐Hydroxypyrazoles.
Authors: Shaw Arthur Y. , McLaren Jonathan A. , Nichol Gary S. , Hulme Christopher 
Published: August 2012

AbstractA three‐step sequence is presented via Ugi four‐component reaction followed by debenzylation and cyclization with hydrazine.
ChemInform Abstract: Synthesis and Biological Activities of Some New Thiazolidine Derivatives Containing Pyrazole Ring System.
Authors: Nishida Sho , Maruoka Hiroshi , Yoshimura Yuki , Goto Takao , Tomita Ryoko , Masumoto Eiichi , Okabe Fumi , Yamagata Kenji , Fujioka Toshihiro 
Published: August 2012

AbstractCompounds (III), obtained by Knoevenagel‐type condensation reaction, undergo dimerization with sodium hydride to afford spirocyclic thiazoles (IV).
ChemInform Abstract: A Convenient Metal‐Free Method for the Synthesis of Benzothiazolethiones from o‐Haloanilines and Carbon Disulfide.
Authors: Zhao Peng , Wang Fei , Xi Chanjuan 
Published: August 2012

Abstracto‐Bromoanilines including N‐substituted derivatives and the iodo analogue (Ia) are transformed to the desired products in the presence of CS2 and DBU.
ChemInform Abstract: Amine‐Catalyzed [3 + 2] Huisgen Cycloaddition Strategy for the Efficient Assembly of Highly Substituted 1,2,3‐Triazoles.
Authors: Wang Lei , Peng Shiyong , Danence Lee Jin Tu , Gao Yaojun , Wang Jian 
Published: August 2012

AbstractThe organocatalyzed Huisgen [3 + 2] cycloaddition allows the synthesis of 1,2,3.triazoles with a diverse set of functional groups in the 1‐, 4‐, or 5‐positions.
ChemInform Abstract: Oxidative Transformations of 4‐Methylcoumarins Using Dimethyldioxirane.
Authors: Cavar Sanja , Kovac Franci 
Published: August 2012

Abstract4‐Methylcoumarins (I) are regioselectively oxidized by dimethyldioxirane to give the corresponding hydroxy (II) and epoxy derivatives (III).
ChemInform Abstract: Hydroxyl Substitutional Effect on Selective Synthesis of cis, trans Stilbenes and 3‐Arylcoumarins Through Perkin Condensation.
Authors: Xiao Chun‐Fen , Zou Yong , Du Jiang‐Li , Sun Hong‐Yi , Liu Xian‐Ke 
Published: August 2012

AbstractA dramatic effect of hydroxyl groups in the reaction of arylacetic acids with benzaldehydes is found.
ChemInform Abstract: Convergent Synthetic Route to Pyrano[2,3‐a]carbazole by Multicomponent Reaction.
Authors: Yamuna Ezhumalai , Prabakaran Kumaresan , Zeller Matthias , Prasad Karnam Jayarampillai Rajendra 
Published: August 2012

AbstractAdvantages of the introduced method are easy work‐up, mild reaction conditions, good yield and environmental friendliness.
ChemInform Abstract: Synthesis and Antitumor Activity of Some Novel Hydrazide, 1,2‐Dihydropyridine, Chromene, and Benzochromene Derivatives.
Authors: Ghorab Mostafa M. , Al‐Said Mansour S. 
Published: August 2012

AbstractHydrazidehydrazone derivative (I) undergoes heterocyclization reactions via its reaction with aromatic aldehydes (II) or arylidenemalononitriles (IV) to produce arylidene and dihydropyridine derivatives (III) and (V), respectively.
ChemInform Abstract: Practical and Scalable Synthesis of Ethyl (R)‐Piperidine‐3‐acetate.
Authors: Zhu Ying‐Guang , Kan Hong‐Zhu , Jiang Li‐Qin , Hu Wen‐Hao 
Published: August 2012

AbstractKey feature of the novel synthesis of ethyl (R)‐piperidine‐3‐acetate is the hydrogenation of N‐benzylpyridinium chloride (I) to afford the racemic ethyl piperidinylacetate (II), which can be kinetically resolved by use of enantiopure mandelic acid.
ChemInform Abstract: Direct Asymmetric Mannich Reaction of Phthalides: Facile Access to Chiral Substituted Isoquinolines and Isoquinolinones.
Authors: Luo Jie , Wang Haifei , Zhong Fangrui , Kwiatkowski Jacek , Xu Li‐Wen , Lu Yixin 
Published: August 2012

AbstractA variety of 3,3‐disubstituted phthalides (III) is prepared by an asymmetric Mannich reaction of esters (I) with imines (II) in the presence of a quinidine‐based multifunctional catalyst.
ChemInform Abstract: Efficient Synthesis of 3‐Aminoimidazo[1,2‐a] Pyridines Using Silica‐Supported Perchloric Acid (HClO4—SiO2) as a Novel Heterogeneous Catalyst.
Authors: Habibi Azizollah , Tarameshloo Zahra , Rostamizadeh Shahnaz , Amani Ali M. 
Published: August 2012

AbstractImidazo[1,2‐a]pyridines (IV) are obtained smoothly by a three‐component condensation of 2‐aminopyridines, aromatic aldehydes and isocyanides in the presence of silica‐supported perchloric acid.
ChemInform Abstract: Acetalization of Carbonyl Compounds as Pentaerythritol Diacetals and Diketals in the Presence of Cellulose Sulfuric Acid as an Efficient, Biodegradable and Reusable Catalyst.
Authors: Shaterian Hamid Reza , Rigi Fatemeh 
Published: August 2012

AbstractThe reaction is conducted under solvent‐free, environmentally benign conditions.
ChemInform Abstract: Xanthan Sulfuric Acid: A New and Efficient Biosupported Solid Acid Catalyst for the Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐ones.
Authors: Kuarm B. Suresh , Madhav J. Venu , Laxmi S. Vijaya , Rajitha B. 
Published: August 2012

AbstractOne‐pot three‐component reaction of β‐ketoester (I) with aldehydes (II) and (thio)urea (III) proceeds smoothly in the presence of xanthan sulfuric acid as catalyst.
ChemInform Abstract: Microwave‐Promoted Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐(thio)ones Using IL‐ONO as Recyclable Base Catalyst under Solvent‐Free Conditions.
Authors: Mirzai Mortaza , Valizadeh Hassan 
Published: August 2012

AbstractThe introduced nitrite ionic liquid can be reused as catalyst for five consecutive cycles of the Biginelli reaction without loss in efficiency.
ChemInform Abstract: Tandem Synthesis of 2,3‐Dihydroquinazolin‐4(1H)‐ones on Grinding under Solvent‐Free Conditions.
Authors: Ding Quan‐Sheng , Zhang Ji‐Lei , Chen Jiu‐Xi , Liu Miao‐Chang , Ding Jin‐Chang , Wu Hua‐Yue 
Published: August 2012

AbstractTandem reaction of anthranilamides or anthranilhydrazides with aliphatic and aromatic aldehydes on grinding under citric acid promotion provides a library of dihydroquinazolinones with good to excellent yields.
ChemInform Abstract: Efficient Synthesis of Pyrimido[5,4‐c]pyridazines and of Thiino[2,3‐d]pyrimidines Based on an Aza‐Wittig Reaction/Heterocyclization Strategy.
Authors: Barsy Magda A. , El Rady Eman A. , Ismael Mostafa A. 
Published: August 2012

AbstractPyrimidopyridazines (VI) and thiinopyrimidines (XI) are synthesized by a domino aza‐Wittig—heterocyclization reaction of phosphazenes (III) and (X) with phenylisocyanate (IV) and amines (V).
ChemInform Abstract: An Efficient One‐Pot Synthesis of Pyrimido[2,1‐b][1,3]oxazine Derivatives via the Reaction of Isocyanides with Dialkyl Acetylenedicarboxylates in the Presence of 5‐Substituted Uracils.
Authors: Baharfar Robabeh , Baghbanian Seyed Meysam 
Published: August 2012

AbstractThe reaction between dialkyl acetylenedicarboxylates (II) and alkyl isocyanides (III) produces a reactive 1:1 adduct which is trapped by uracil derivatives (I) to provide the highly functionalized pyrimidooxazines (IV).
ChemInform Abstract: Synthesis of Novel Pyrazolo[3,4‐d]pyrimidines peri‐Fused with 1,4‐Diazepine, 1,4‐Thiazepine, and 1,2,4‐Triazepine Rings.
Authors: Masevicius Viktoras , Juskenas Robertas , Tumkevicius Sigitas 
Published: August 2012

AbstractHitherto unknown ortho‐ and peri‐fused heterocyclic systems incorporating structural units of pyrazole, pyrimidine, 1,4‐diazepine, and 1,2,4‐triazepine are prepared.
ChemInform Abstract: Melanogenesis Inhibitory Bisabolane‐Type Sesquiterpenoids from the Roots of Angelica koreana.
Authors: Hwang Bang Yeon , et al. et al. 
Published: August 2012

AbstractBioactivity‐guided isolation leads to the identification of four new bisabolane‐type sesquiterpenoids, named osterivolone A (Ia), B (Ib), C (II) and D (III), together with four known natural substances.
ChemInform Abstract: Synthesis of (.+‐.)‐Bimatoprost.
Authors: Harikrishna M. , Mohan H. Rama , Dubey P. K. , Shankar M. , Subbaraju Gottumukkala V. 
Published: August 2012

AbstractA facile approach for the synthesis of key intermediate (V), which can be elaborated into several ophthalmic prostaglandins, is developed starting from Corey lactone.
ChemInform Abstract: Nonlinear Photochemistry and 3D Microfabrication with Q‐Switched Nd:YAG Microchip Lasers
Authors: Baldeck Patrice L. , Scheul Teodora , Bouriau Michel , Stephan Olivier , Malval Jean‐Pierre , Lin Chih‐Lang , Lin Chin‐Te , Tseng Chang‐Li , Huang Cheng , Chung Tien‐Tung 
Published: August 2012

AbstractReview: 15 refs.
Enhanced External Counterpulsation Has No Lasting Effect on Ambulatory Blood Pressure
Authors: May Ole , Khair Wael Abdulla Mohammed 
Published: August 2012

AbstractBackground:Enhanced external counterpulsation (EECP) has been reported to reduce blood pressure (BP) using clinic BP readings. The aim of this study was to assess the effect of a course of EECP on BP using ambulatory BP (ABP) measurements.Hypothesis:EECP has a lasting BP lowering effect.Methods:Patients referred for EECP due to refractory angina pectoris were consecutively included in the study. The ABPs were measured for 24 hours using a Spacelabs Ultralite 90217 device at 5 time points during the study period: 2 months before the EECP course, just before the EECP course, just after the EECP course, and at 3 and 12 months after EECP. Antihypertensive medication was held constant during the study period. Changes in BP were tested by repeated measures analysis.Results:Fifty patients were included in the study. The mean age was 63 years, and 72% were male. The Canadian Cardiovascular Society Angina Grading Scale class improved from a mean of 2.6 to 1.5. The mean daytime ABPs were 114/69, 114/70, 115/71, 114/70, and 116/71 mm Hg and the mean nighttime ABPs were 107/63, 108/63, 106/62, 108/63, and 107/62 mm Hg at 2 months before the EECP course, just before the EECP course, just after the EECP course, and at 3 and 12 months after EECP, respectively (all P > 0.10). Further, when controlling for quartiles of baseline ABP level, no significant change in ABP was found.Conclusions:Enhanced external counterpulsation treatment has no lasting effect on ABP.The study was supported by a grant from the Danish Heart Foundation (grant no. 06‐10‐B551‐A1204‐22346) and from “Ringkøbing Amts Sundhedsvidenskabelige Forskningsfond.” The authors have no other funding, financial relationships, or conflicts of interest to disclose.
Spontaneous glycine‐induced calcium transients in spinal cord progenitors promote neurogenesis
Authors: Brustein Edna , Côté Sébastien , Ghislain Julien , Drapeau Pierre 
Published: August 2012

AbstractGlycine and GABA are depolarizing during early development, but the purpose of this paradoxical chloride‐mediated depolarization remains unclear, especially at early stages. It was previously reported that suppressing glycine signaling from the beginning of development in zebrafish embryos caused an abnormal maintenance of the progenitor population and a specific reduction of spinal interneurons but not of other cell populations. Here, we show that cells including progenitors in the embryonic spinal cord had occasional spontaneous, glycine‐mediated calcium transients that were blocked by the glycine antagonist strychnine and the L‐type calcium channel blocker nifedipine. As shown previously for chronic block by strychnine, block of these transients by nifedipine reduced interneuron differentiation. Our results indicate that glycinergic depolarization of neural progenitors evokes spontaneous calcium transients that may enhance the interneuron neurogenic program. © 2012 Wiley Periodicals, Inc. Develop Neurobiol, 2013
Choice of hydrogen uptake (Hup) status in legume‐rhizobia symbioses
Authors: Annan Henry , Golding Amber‐Leigh , Zhao Yinping , Dong Zhongmin 
Published: August 2012

AbstractThe
H

2 is an obligate by‐product of N‐fixation. Recycling of
H

2 through uptake hydrogenase (Hup) inside the root nodules of leguminous plants is often considered an advantage for plants. However, many of the rhizobium‐legume symbioses found in nature, especially those used in agriculture are shown to be Hup−, with the plants releasing
H

2 produced by nitrogenase activity from root nodules into the surrounding rhizosphere. Recent studies have suggested that,
H

2 induces plant‐growth‐promoting rhizobacteria, which may explain the widespread of Hup− symbioses in spite of the low energy efficiency of such associations. Wild legumes grown in Nova Scotia, Canada, were surveyed to determine if any plant‐growth characteristics could give an indication of Hup choice in leguminous plants. Out of the plants sampled, two legumes,
Securigera varia and
Vicia cracca, showed Hup+ associations.
Securigera varia exhibited robust root structure as compared with the other plants surveyed. Data from the literature and the results from this study suggested that plants with established root systems are more likely to form the energy‐efficient Hup+ symbiotic relationships with rhizobia. Conversely, Hup− associations could be beneficial to leguminous plants due to
H

2‐oxidizing plant‐growth‐promoting rhizobacteria that allow plants to compete successfully, early in the growing season. However, some nodules from
V. cracca tested Hup+, while others were Hup−. This was similar to that observed in
Glycine max and
Pisum sativum, giving reason to believe that Hup choice might be affected by various internal and environmental factors.
Unsaturated Organic Derivatives of Phosphaferrocene – Synthesis and Reactivity of Vinyl‐ and Alkynylphosphaferrocenes
Authors: Faßbender Julia , Frank Walter , Ganter Christian 
Published: August 2012

AbstractStarting from 2‐formyl‐3,4‐dimethylphosphaferrocene, a series of vinyl‐substituted phosphaferrocenes was prepared by Wittig and related olefination reactions. The parent 3,4‐dimethyl‐2‐vinylphosphaferrocene (2) could be selectively converted to either the terminal or branched alcohols 8b and 8a by hydroboration/oxidation or protonation in aqueous solution, respectively. Elimination of HBr from 2‐bromovinylphosphaferrocene 9 provided access to the 2‐ethynylphosphaferrocene derivative 10, which could be converted to other alkynes by deprotonation and electrophilic quench. Additionally, the syntheses of the 2‐cyano‐ (15) and 2‐(ethoxycarbonyl)phosphaferrocene derivative 13 are reported. Several new phosphaferrocenes were converted into their respective Fe(CO)4 complexes, which were investigated by IR spectroscopy. The CO stretching vibrations were found to depend on the nature of the substituent in the 2‐position and the cyano compound 15 was identified as the least electron‐donating ligand. Reaction of the alkynylphosphaferrocenes 10 and 11 with Co2(CO)8 afforded the respective dimetallatetrahedrane complexes 24 and 25. The molecular structures of compounds 12, 21 and 25 have been determined by X‐ray diffraction analysis.
Synthesis and Reactivity of the 3‐Substituted Isoindolinone Framework to Assemble Highly Functionalized Related Structures
Authors: Petronzi Carmen , Collarile Selene , Croce Gianluca , Filosa Rosanna , De Caprariis Paolo , Peduto Antonella , Palombi Laura , Intintoli Valentina , Di Mola Antonia , Massa Antonio 
Published: August 2012

AbstractAn efficient potassium carbonate‐catalyzed synthesis of 3‐substituted isoindolinones through tandem aldol/cyclization reactions of active methylene compounds with 2‐cyanobenzaldehyde is described. The utility of the obtained isoindolinones has been demonstrated through an exploration of the chemical space by employing a series of interesting methodologies that led to diverse, highly functionalized compounds. Among them, a surprisingly straightforward potassiumcarbonate‐catalyzed double tandem reaction led to tricyclic hemiaminal derivatives.