bluuebunny/crossref_metadata_2025_split huggingface dataset:
The value of plasma omega-3 polyunsaturated fatty acids in predicting the response and prognosis of cervical squamous cell carcinoma patients to concurrent chemoradiotherapy
Authors: Ping Pengbin , Li Juan , Xu Xiaoying 
Published: May 2024

Background: In recent years, abnormalities in plasma omega-3 polyunsaturated fatty acids (omega-3 PUFAs) have been proven to be related to the risk of cancer, but their prognostic value for cancer is unclear. The purpose of this study was to retrospectively evaluate the response and prognostic significance of plasma omega-3 PUFAs in patients with cervical squamous cell carcinoma (CSCC) treated with concurrent chemoradiotherapy (CCRT). Spearman rank correlation analysis was used to analyze the correlation between omega-3 PUFAs and squamous cell carcinoma antigen (SCC-Ag) levels.Methods: A total of 89 patients with CSCC who underwent CCRT were evaluated retrospectively. Binary logistic regression analysis was used to analyze the independent predictors related to complete response (CR) after CCRT. A Cox proportional hazard model and Kaplan-Meier analysis were utilized to perform survival analysis.Results: According to multivariate logistic regression analyses, a high level of plasma EPA was independently correlated with an increased incidence of CR after CCRT (odds ratio (OR), 0.980; 95% confidence interval (CI), 0.962–0.999, p = 0.038). With a median follow-up of 41.3 months, the CSCC patients in the high EPA (≥46.0 nmol/mL) group exhibited longer OS and PFS. According to our multivariate analysis, pretreatment plasma EPA level was an independent prognostic factor for PFS in patients with CSCC who underwent CCRT (hazard ratio (HR), 0.263; 95% CI, 0.089–0.782, p = 0.016). However, it was not an independent prognostic factor of OS. Spearman rank correlation analysis revealed was a negative correlation between pretreatment SCC-Ag (pre SCC-Ag) levels and EPA levels (r = −0.305, p = 0.004), and a weak negative correlation between posttreatment SCC-Ag (post SCC-Ag) levels and EPA levels (r = −0.251, p = 0.018).Conclusion: Plasma omega-3 PUFAs are related to the response and survival outcome of patients with CSCC who underwent CCRT. Pretreatment plasma EPA levels may be a promising biomarker for predicting the response and prognosis of patients with CSCC who undergo CCRT. In addition, the pretreatment plasma EPA levels presented a negative correlation with the SCC-Ag levels.
Chinese herbal medicine Shufeng Jiedu capsule for mild to moderate COVID-19: a multicenter, randomized, double-blind, placebo-controlled phase II trial
Authors: Lu Chun-li , Yang Liu-qing , Jin Xin-yan , Friedemann Thomas , Li Yu-fei , Liu Xue-han , Chen Xiao-ying , Zou Xiang-yun , Zhang Bing-rui , Wang Fu-xiang , Lin Yuan-long , Tang Yi-min , Cao Meng-li , Jiang Ya-lin , Gao You-fang , Liu Kui , Tao Zhen-gang , Robinson Nicola , Schröder Sven , Liu Jian-ping , Lu Hong-zhou 
Published: May 2024

Background: The COVID-19 pandemic has had a profound global impact, although the majority of recently infected cases have presented with mild to moderate symptoms. Previous clinical studies have demonstrated that Shufeng Jiedu (SFJD) capsule, a Chinese herbal patent medicine, effectively alleviates symptoms associated with the common cold, H1N1 influenza, and COVID-19. This study aimed to assess the efficacy and safety of SFJD capsules in managing symptoms of mild to moderate COVID-19 infection.Methods: A randomized, double-blind, placebo-controlled trial was conducted from May to December 2022 at two hospitals in China. Mild and moderate COVID-19-infected patients presenting respiratory symptoms within 3 days from onset were randomly assigned to either the SFJD or placebo groups in a 1:1 ratio. Individuals received SFJD capsules or a placebo three times daily for five consecutive days. Participants were followed up for more than 14 days after their RT-PCR nucleoid acid test for SARS-CoV-2 turned negative. The primary outcome measure was time to alleviate COVID-19 symptoms from baseline until the end of follow-up.Results: A total of 478 participants were screened; ultimately, 407 completed the trial after randomization (SFJD, n = 203; placebo, n = 204). No statistically significant difference in baseline parameters was observed between the two groups. The median time to alleviate all symptoms was 7 days in the SFJD group compared to 8 days in the placebo group (p = 0.037). Notably, the SFJD group significantly attenuated fever/chills (p = 0.04) and headache (p = 0.016) compared to the placebo group. Furthermore, the median time taken to reach normal body temperature within 24 h was reduced by 7 hours in the SFJD group compared to the placebo group (p = 0.033). No deaths or instances of serious or critical conditions occurred during this trial period; moreover, no serious adverse events were reported.Conclusion: The trial was conducted in a unique controlled hospital setting, and the 5-day treatment with SFJD capsules resulted in a 1-day reduction in overall symptoms, particularly headache and fever/chills, among COVID-19-infected participants with mild or moderate symptoms. Compared to placebo, SFJD capsules were found to be safe with fewer side effects. SFJD capsules could potentially serve as an effective treatment for alleviating mild to moderate symptoms of COVID-19.Clinical Trial Registration: https://www.isrctn.com/, identifier ISRCTN14236594.
Efficacy and safety of anti-angiogenic drug monotherapy and combination therapy for ovarian cancer: a meta-analysis and trial sequential analysis of randomized controlled trials
Authors: Xie Yao , Zhou Fei 
Published: May 2024

BackgroundAs the development of novel anti-angiogenic drugs and the continuous evolution of guideline recommendations, the efficacy and safety of anti-angiogenic agents in ovarian cancer (OC) remains unclear. Consequently, a meta-analysis was carried out to assess the efficacy and safety of anti-angiogenic drug monotherapy and combination therapy for OC.MethodsAn exhaustive literature review was performed across multiple databases, including PubMed, Embase, Web of Science, and Cochrane, encompassing all relevant randomized controlled trials (RCTs) up until 6 April 2024. The evaluation of efficacy outcomes incorporated progression-free survival (PFS), overall survival (OS), and objective response rate (ORR). Safety was assessed through the occurrence of any grade adverse events (AEs) and grade ≥3 AEs. Synthesis of the data involved the calculation of hazard ratios (HRs), relative risks (RRs), and their corresponding 95% confidence intervals (CIs) and prediction intervals (PIs). Trial sequential analysis was executed employing TSA v0.9.5.10 Beta software, STATA 12.0, and R software 4.3.1.ResultsIn this meta-analysis, 35 RCTs were included, encompassing 16,199 subjects in total. The overall analysis indicated that anti-angiogenic drug combination therapy significantly improved PFS (HR [95% CI] = 0.678 [0.606–0.759], 95% PI: 0.415–1.108), OS (HR [95% CI] = 0.917 [0.870–0.966], 95% PI: 0.851–0.984), and ORR (RR [95% CI] = 1.441 [1.287–1.614], 95% PI: 1.032–2.014), but also increased the incidence of grade ≥3 AEs (RR [95% CI] = 1.137 [1.099–1.177], 95% PI: 1.011–1.252). The analysis did not corroborate any benefit of anti-angiogenic monotherapy over placebo concerning PFS (HR [95% CI] = 0.956 [0.709–1.288], 95% PI: 0.345–2.645) and OS (HR [95% CI] = 1.039 [0.921–1.173], 95% PI: 0.824–1.331). However, it was observed that monotherapy with anti-angiogenic drugs did increase the incidence of any grade AEs (RR [95% CI] = 1.072 [1.036–1.109], 95% PI: 0.709–1.592).ConclusionOur study confirmed the PFS, OS, and ORR benefits of anti-angiogenic drug combination therapy for OC patients. The efficacy results of anti-angiogenic monotherapy necessitates further evaluation as more RCTs become available. Clinicians should be vigilant of AEs when administering anti-angiogenic agents in a clinical setting.
Investigating the influence of gamification on motivation and learning outcomes in online language learning
Authors: Shen Zijun , Lai Minjie , Wang Fei 
Published: May 2024

IntroductionThis study investigates the influence of gamification integration on language learning achievement among Chinese students while probing the mediating role of learners' motivation. Furthermore, it extends the boundaries of this investigation by exploring the moderating effect of digital literacy as a psychological predisposition.MethodsData is collected through surveys from Chinese students enrolled in linguistic programs, employing a stratified random sampling technique and analyzed via SmartPLS SEM.ResultsThe findings affirm the significant and positive impact of gamification integration on language learning achievement. The study introduces a moderated mediation model where learners' motivation serves as the mediator, and digital literacy acts as a moderator, further accentuating the significant impact of this integrated approach.DiscussionThis research advances our theoretical understanding of language learning, validating gamification's effectiveness as a motivational tool, and introduces digital literacy as a critical factor, providing deeper insights into personalized language learning experiences.
Anthropology and ethnobotany in health mediation: an illustration of a clinical, personalized approach for Haitian migrants in a French Guianese hospital
Authors: Tareau Marc-Alexandre , Demars Yoris , Alcouffe Leslie , Pierre-Louis Ruth , Walter Gaelle , Djossou Félix , Vignier Nicolas , About Frédégonde 
Published: May 2024

IntroductionIn French Guiana, a European territory in Guiana shield in the Amazon area, close to 40% of the current population was born abroad. In this context, it is important to listen to the experiences of migrants to better understand the difficulties encountered within the healthcare pathways. This is the aim of ANRS Parcours d’Haïti project, an epidemiological, biographical and socio-anthropological study conducted on a representative sample of the Haitian community in French Guiana and focusing on the social determinants of health.MethodologyWithin the framework of this study, the Infectious and Tropical Diseases clinical team of Cayenne Hospital has established close collaboration with health mediators and the ethnobotanist anthropologist of the study. To illustrate the contribution of a personalized approach to health mediation, we report the case of a migrant woman of Haitian origin admitted to the Infectious and Tropical Diseases Unit. We highlight the different socio-cultural aspects addressed and their place in the care process through a thematic discussion and socio-anthropological analysis of the care relationship, based on participatory ethnography and inductive analysis of an in-depth interview with the patient.ResultThis example illustrates the need for a multidisciplinary approach to ensure culturally adapted care for patients. Personal interviews are important because they allow to better take into account the cultural specificities of patients’ experiences and the socio-cultural environment in which they live (and especially, in the case of Haitian patients, their religious affiliation). By allowing them to speak and express themselves freely, they integrate not only their own cultural baggage, but also their own expectations and representations of the disease they suffer from and how it should be treated. Ultimately, this tripartite collaboration between patient, caregiver, and anthropologist or health mediator leads to a better therapeutic alliance.ConclusionThe analysis of this health care relationship is emblematic of the issue of cultural competence and pre-conceptualizes what intercultural mediation in health care could be, as close as possible to the caregiver and the individual.
Association between the arm circumference and non-alcoholic fatty liver disease in American children and adolescence: a population-based analysis
Authors: Weng Xiaolu , Xu Jing , Yang Shouxing 
Published: May 2024

BackgroundThe arm circumference (AC) has been used as an important tool to access the risk of non-alcoholic fatty liver disease (NAFLD) in adults. However, the association between AC and NAFLD in children and adolescence remains unclear. This study aims to explore the relationship between AC and NAFLD in American children and adolescence.Methods2017–2020 National Health and Nutrition Examination Survey (NHANES) was used to carry out the cross-sectional study. The association between AC and the risk of NAFLD, and liver steatosis was analyzed using weighted multivariable logistic regression and multivariate linear regression. Additionally, a two-part linear regression model was used to identify threshold effects in this study. Subgroup analysis, interaction tests and receiver operating characteristic (ROC) curve analysis were also carried out.ResultsA total of 1,559 children and adolescence aged 12–18 years old were included, and the prevalence of NAFLD was 27.3%. AC was positively correlated with the risk of NAFLD (OR = 1.25, 95% CI: 1.19, 1.32) and liver steatosis (β = 4.41, 95% CI: 3.72, 5.09). Subgroup analysis stratified by age and race showed a consistent positive correlation. A non-linear relationship and saturation effect between AC and NAFLD risk were identified, with an S shaped curve and an inflection point at 34.5 cm. Area under the ROC of AC to NAFLD was 0.812, with the sensitivity of 67.6%, the specificity of 83.8% and the cutoff value of 31.7 cm.ConclusionOur study shows that AC is independently correlated with an increased risk of NAFLD and the severity of liver steatosis in American children and adolescence.
Myotonometry and extended field-of-view ultrasound imaging allow reliable quantification of patellar tendon stiffness and length at rest and during maximal load, whereas several restrictions exist for the Achilles tendon
Authors: Wegener Florian , Ritterbusch Arne , Saal Christian , Baumgart Christian , Hoppe Matthias W. 
Published: May 2024

IntroductionStiffness and length are well-established tendon parameters in sports and medicine. Myotonometry and ultrasound imaging are the commonly used methods to quantify these parameters. However, further studies are needed to clarify the reliability of these methods, especially when assessing maximally loaded tendons and when conducted by different experienced investigators. This study aimed to determine the intra- and interrater reliabilities of measuring the stiffness and length of the patellar tendon (PT) and Achilles tendon (AT) using the myotonometry method and the extended field-of-view ultrasound (EFOV-US) technique at rest and maximal load performed by different experienced investigators.MethodsTwenty-seven participants were examined on three different days by one experienced investigator and one novice investigator. Primary outcomes were the intraclass correlation coefficient (ICC) and associated 95% confidence interval (95% CI), coefficient of variation (CV), standard error of measurement (SEM), and minimal detectable change (MDC) across the measurement days and investigators.ResultsFor PT measurements at rest and maximal load, the estimated ICCs for stiffness and length were ≥.867 and ≥.970, respectively, with 95% CIs ranging from poor (.306) to excellent (.973) and good (.897) to excellent (.999). The CV, SEM, and MDC for PT stiffness and length were ≤5.2% and ≤2.0%, ≤39.3 N/m and ≤0.9 mm, and ≤108.9 N/m and ≤2.6 mm, respectively. For AT measurements, some restrictions were evident for stiffness at rest and both parameters at maximal load. However, regarding AT length at rest, the estimated ICC was ≥.996, with an excellent 95% CI (.987–.999). The CV, SEM, and MDC for AT length at rest were 2.8%, ≤1.1 mm, and ≤2.9 mm, respectively.ConclusionThe estimated ICCs show good to excellent reliability for the myotonometry method and the EFOV-US technique for measuring PT stiffness and length at rest and maximal load for experienced and novice investigators. However, some restrictions are evident for the AT, especially for measurements at maximal load.
The effect of an intraoperative patient-specific, surgery-specific haemodynamic algorithm in improving textbook outcomes for hepatobiliary–pancreatic surgery: a multicentre retrospective study
Authors: Carp Bradly , Weinberg Laurence , Fletcher Luke R. , Hinton Jake V. , Cohen Adam , Slifirski Hugh , Le Peter , Woodford Stephen , Tosif Shervin , Liu David , Muralidharan Vijaragavan , Perini Marcos V. , Nikfarjam Mehrdad , Lee Dong-Kyu 
Published: May 2024

BackgroundThe concept of a “textbook outcome” is emerging as a metric for ideal surgical outcomes. We aimed to evaluate the impact of an advanced haemodynamic monitoring (AHDM) algorithm on achieving a textbook outcome in patients undergoing hepatobiliary–pancreatic surgery.MethodsThis retrospective, multicentre observational study was conducted across private and public teaching sectors in Victoria, Australia. We studied patients managed by a patient-specific, surgery-specific haemodynamic algorithm or via usual care. The primary outcome was the effect of using a patient-specific, surgery-specific AHDM algorithm for achieving a textbook outcome, with adjustment using propensity score matching. The textbook outcome criteria were defined according to the International Expert Delphi Consensus on Defining Textbook Outcome in Liver Surgery and Nationwide Analysis of a Novel Quality Measure in Pancreatic Surgery.ResultsOf the 780 weighted cases, 477 (61.2%, 95% CI: 57.7%–64.6%) achieved the textbook outcome. Patients in the AHDM group had a higher rate of textbook outcomes [n = 259 (67.8%)] than those in the Usual care group [n = 218 (54.8%); p &lt; 0.001, estimated odds ratio (95% CI) 1.74 (1.30–2.33)]. The AHDM group had a lower rate of surgery-specific complications, severe complications, and a shorter hospital length of stay (LOS) [OR 2.34 (95% CI: 1.30–4.21), 1.79 (95% CI: 1.12–2.85), and 1.83 (95% CI: 1.35–2.46), respectively]. There was no significant difference between the groups for hospital readmission and mortality.ConclusionsAHDM use was associated with improved outcomes, supporting its integration in hepatobiliary–pancreatic surgery. Prospective trials are warranted to further evaluate the impact of this AHDM algorithm on achieving a textbook impact on long-term outcomes.
Faits et gestes du renard en Ardenne
Authors: Vincent Odile 
Published: May 2024

Three aspects of the relationships between people of the Ardennes and the fox are explained here, each of them function of a particular social definition of the person concerned : the relationship between the fox and the women, who look after the poultry, that between the fox and hunters (particulary poachers) and lastly, that between the fox who propagates rabies and the population as a whole.
In the first two relationships, the fox shows the same characteristics : he is autonomous, artful, asocial and seductive but at the same time aggressive. When rabies breaks out the fox's status is transformed : reactions to him change ; the fox carrier of rabies loses the place which was traditionnally attributed to him, and becomes an animal to be eliminated.
حديث (الولد للفراش): دراسة أصولية تحليلية
Authors: الهبيط أحمد محمد هادي 
Published: May 2024

يهدف البحث إلى استثمار نص حديث "الولد للفراش" أصوليا؛ باستخراج دلالات ألفاظ الحديث الأصولية، ودراسة المسائل الأصولية التي ناقشها العلماء استشهادا بالحديث أو استنباطا منه. ولأن الكلام على تلك المسائل مفرق في الكتب؛ خصوصا شروح الأحاديث وكتب أصول الفقه، فإن البحث سيقوم بجمع شتاتها، ونظمها في سلك واحد. وقد اعتمد البحث المنهج الاستقرائي التحليلي، وذلك بتتبع مظان البحث من المراجع، ثم تحليل المعلومات المستفادة واستنباط الأحكام منها. ويتكون البحث من: مقدمة وتمهيد وأربعة مباحث وخاتمة. جاء التمهيد: في الحديث وأهميته، وجاء المبحث الأول في دلالات ألفاظ الحديث، وناقش المبحث الثاني: مسائل العموم والخصوص في الحديث، وجاء المبحث الثالث في الأدلة الإجمالية والأحكام المستفادة من الحديث، وتوصل البحث إلى النتائج الآتية: تجلى في حديث (الولد للفراش وللعاهر الحجر) جوامع الكلم الذي وصف النبي صلى الله عليه وسلم بها كلامه. ظهر من البحث سعة دلالات ألفاظ الحديث الأصولية وعمقها وتنوعها. كشف البحث أجوبة العلماء على الإشكال الناتج من قضاء النبي صلى الله عليه وسلم بالغلام لعبد بن زمعة؛ وأمر أخته سودة بنت زمعة بالاحتجاب منه، وهذه الأجوبة تمثلت في القواعد الآتية: قاعدة الاحتياط والورع ومراعاة الخلاف، وقاعدة الحكم بين حكمين وتبعيض الأحكام، وقاعدة المنع من المباح للمصلحة.
VILLAGE BRANDING BASED ON DEVELOPMENT OF MSMEs
Authors: Mohammad Ikhsan Kurnia  
Published: May 2024

Village branding based on the development of Micro, Small and Medium Enterprises (MSMEs) is an innovative approach that aims to increase the economic potential and welfare of village communities. Village branding integrated with MSME development can create an environment that supports local business growth, increases market access, and optimizes the use of local resources. Apart from that, village branding also contributes to increasing community skills and knowledge, increasing their participation in decision-making processes, and improving basic infrastructure that supports economic sustainability. This research aims to get an overview of village branding based on MSME development in Indonesia which has been studied by researchers based on community service activities carried out by university personnel. The approach used is a qualitative approach with a literature review method based on data obtained from the Garuda Platform. This research succeeded in reviewing 9 literature documents regarding MSME-based village branding. The results of the literature review identified problems faced by MSMEs in Indonesia, including lack of literacy about branding, digital marketing, operational management, financial management and use of technology.

Keywords: MSMEs, Village, Brand, Literature Review.
Civilising Pressures in Globally Expanding Networks of Functional Interdependence: Power Inequalities and Equalities.
Authors: Wouters Cas 
Published: May 2024

Over the past three hundred years, with the emancipation of people as individuals and groups, social definitions of differences in inequality and equality -particularly those in social and political power, wealth and rank - have increasingly shifted from being designated as ‘bad luck’ in the direction of ‘social injustice’. These are now debated as signs of changing social power relations, both in economic and political terms. On a global level, increasing inequality is reported to coincide with the reduction in these relations, while integration coincides with integration conflicts and with part-processes of disintegration, defunctionalisation and decivilisation. These contradictory directions can be understood by analysing them as tension balances. Two key questions are addressed here: Which side is (or becomes) dominant? At what level of integration does this occur? I show how the contradicting trends of integration and disintegration have been co-dominant: growing social interdependencies such as those based upon the controls of fire, agriculture and industry, have coincided with growing ‘equality’ and ‘inequality’ in power, wealth and rank. They coincided further with rising pressures on everyone involved to take more of each other into account more often, to develop longer-term perspectives, and to identify with other people regardless of their social origins. These pressures in civilising directions include the informalisation of regimes of manners and emotions and their internalisation, processes in which people exercise increasing control over their emotions, feelings and displays of superiority and inferiority in particular, resulting in rising levels of ambivalence and higher levels of trust and distrust.