bluuebunny/crossref_metadata_2025_split huggingface dataset:
On Emotions, Politics and Political Symbols
Authors: Tokdoğan Nagehan 
Published: June 2024

AbstractThis chapter presents a theoretical discussion on the relationship between politics, emotions, and symbols. It describes the intellectual and historical background of the modern tendency in the political science literature to ignore the role of emotion in politics, which was considered an integral phenomenon in classical texts of political philosophy. Based on the claim that emotions are both collective and individual phenomena, this chapter opens the door to a new understanding of emotions in politics and makes it possible to adopt an epistemological position that enables us to deal with the crucial relationship between politics and emotions.
Neo-Ottomanism as an Alternative Narrative of National Identity
Authors: Tokdoğan Nagehan 
Published: June 2024

AbstractBuilding on the theoretical basis for dealing with emotions, politics and symbols together, this chapter takes a historical perspective on Neo-Ottomanist narratives. Drawing on its historical manifestations in modern Turkey, it suggests that the current wave of Neo-Ottomanism is a new and alternative national narrative to the Republican one. It reveals the implications of how Neo-Ottomanism characterized the spirit of the country in the 2000s, not only for the elite, but for much of Turkish society. It thus paves the way for a discussion of the emotional motives behind Neo-Ottomanism.
From Victimization to Omnipotence: The Pathos of Erdoğan as a Constituent Symbol of the Neo-Ottomanist Narrative
Authors: Tokdoğan Nagehan 
Published: June 2024

AbstractThis chapter begins with an analysis of the cult of Erdoğan and his journey from victimhood to omnipotence as the basis of the Neo-Ottomanist narrative and the national emotional mood it addresses. The claim of victimhood has dominated Erdoğan’s political discourse and actions for almost the entirety of the first decade of his leadership. To gain insights into Erdoğan’s leadership, it is essential to ask how he became the symbol of this national emotional trait, and how he gained increasing support by embodying and reflecting the emotions of the people in his political discourse, personal style and behaviour.
Pilot Wave Theory in the Twenty-First Century
Authors: Castro Paulo , W. M. Bush John , Croca José R. 
Published: June 2024

AbstractThis book is the result of the International Conference on Advances in Pilot Wave Theory, hosted by the Centre for Philosophy of Sciences of the University of Lisbon (CFCUL), Portugal, held from 26 to 30 July 2021 (International Conference on Advances in Pilot Wave Theory—Concurrently Hosting Hydrodynamic Quantum Analogs HQA-2021 n.d.; Advances in Pilot Wave Theory & HQA2021—YouTube n.d.). The conference concurrently hosted the Hydrodynamic Quantum Analogs meeting (HQA-2021) owing to the common interests of these seemingly disparate fields. The meeting took place online due to the COVID Pandemic lockdown and attracted participants from distant points of the globe, including the United States, Canada, Brazil, Mexico, Portugal, the United Kingdom, Italy, France, the Netherlands, Germany, Russia, Australia, and Israel.
Ports and Harbours as Special Management Areas
Authors: Chircop Aldo 
Published: June 2024

AbstractAs autonomous federal entities, port authorities in Canada have long been considered as special management areas. Canada’s system for ports managed by port authorities, public ports, and small craft harbours is explained with a focus on how they manage lands and waters within their jurisdiction by using their powers for land use planning and vessel traffic management. Attention is given to governance and how ports use zoning powers to promote efficiency, safety, security, and environmental concerns such as decarbonization of shipping and marine conservation. Canada’s port and harbour practice is assessed from the perspectives of spatial use, governance powers, and environmental protection. The chapter concludes on the practice of ports to treat land use planning and marine spatial planning as a continuum.
The Impact of COVID-19 on Arctic Shipping: An Area-Based Public/Occupational Health Perspective
Authors: Shan Desai , Yadav Om Prakash 
Published: June 2024

AbstractMaritime activities are increasing in the Arctic and near Arctic areas, including domestic shipping and international transit traffic. Arctic shipping has created opportunities for cruise tourism, resource transportation, community supply transportation, research, and government services. However, hazards and challenges inherent to maritime operations in the Canadian Arctic cannot be ignored, including extreme Arctic weather conditions, limited port infrastructure, extensive distances from search and rescue services, and restricted access to medical care in Northern communities. The onset of the COVID-19 pandemic has compounded these challenges, posing a threat to the well-being and safety of seafarers.This chapter explores the occupational health and safety challenges confronted by Canadian Arctic seafarers during the COVID-19 pandemic through qualitative interviews with 20 industry stakeholders, including seafarers, union representatives, managers, and maritime consultants. The findings revealed seafarers’ concerns of increased risks due to pandemic-induced public health measures including lockdowns, travel restrictions, and controls. The deprivation of shore leaves and prolonged isolation from families substantially impacted the mental health of seafarers, amplifying the risks of depression and anxiety. A comprehensive Arctic occupational health and safety (OHS) policy framework is recommended to support seafarers in addressing the above challenges.
The Canadian Regulatory Framework for Area-Based Marine Management of Shipping
Authors: Chircop Aldo , Coffen-Smout Scott 
Published: June 2024

AbstractCanada has a well-developed framework for the management of shipping through area-based management (ABM) approaches which operates in direct and indirect ways. Regulatory tools available for the direct spatial management of shipping are used by federal government and port authorities, followed by indirect ways of spatial management of shipping undertaken by federal agencies through the designation of marine protected areas, national marine conservation areas, marine wildlife areas, marine bird sanctuaries, and fisheries habitat sanctuaries, whose principal purpose is marine conservation, which have incidental effects on shipping. The chapter assesses federal government ABM practices from the perspectives of purposes and functions, implementation of international commitments, allocation of ocean space, and considerations for the integrated approach in ocean management, followed by concluding observations on marine spatial planning and the likelihood that Canada will continue to manage its ocean spaces by using shipping ABM tools on a problem-by-problem basis.
Canadian Arctic Shipping Governance: Incorporating Indigenous Knowledge in Area-Based Management Frameworks and Tools
Authors: Aporta Claudio , Beveridge Leah , Wang Weishan 
Published: June 2024

AbstractThe need for Indigenous rights to be recognized and for reconciliation to occur is becoming increasingly engrained in the fabric of Canada. From the perspective of Indigenous peoples in Canada, reconciliation is seen as a process of decolonization. With the launch of the Oceans Protection Plan in 2016, the narrative of Indigenous engagement was brought directly to the topic of shipping governance. But the question remains: how to achieve reconciliation in concrete and tangible ways through policies and governance procedures? Importantly, reconciliation is not a discrete state or a destination, but a continuous process.In Canada, area-based approaches are becoming more common in the regulation of marine affairs, including shipping. The increasing prevalence of area-based, ecosystem-based approaches is resulting in the development and application of decision support systems (DSSs) that are designed to process, visualize, integrate, and communicate information. While the significance of such DSS cannot be overestimated, a less discussed fact is that the knowledge of coastal communities is remarkably difficult to represent unless it is adapted to the language and requirements of these tools and systems. In practice, this results in decreasing the value of observational, “local” knowledge while increasing the significance of quantifiable “scientific” observations or measurements. This chapter proposes that the ways of treating local knowledge in area-based management can facilitate or hinder processes of reconciliation in the context of ocean governance.
Glycine-induced activation of GPR158 increases the intrinsic excitability of medium spiny neurons in the nucleus accumbens
Authors: Aceto Giuseppe , Nardella Luca , Nanni Simona , Pecci Valeria , Bertozzi Alessia , Nutarelli Sofia , Viscomi Maria Teresa , Colussi Claudia , D’Ascenzo Marcello , Grassi Claudio 
Published: June 2024

AbstractIt has been recently established that GPR158, a class C orphan G protein-coupled receptor, serves as a metabotropic glycine receptor. GPR158 is highly expressed in the nucleus accumbens (NAc), a major input structure of the basal ganglia that integrates information from cortical and subcortical structures to mediate goal-directed behaviors. However, whether glycine modulates neuronal activity in the NAc through GPR158 activation has not been investigated yet. Using whole-cell patch-clamp recordings, we found that glycine-dependent activation of GPR158 increased the firing rate of NAc medium spiny neurons (MSNs) while it failed to significantly affect the excitability of cholinergic interneurons (CIN). In MSNs GPR158 activation reduced the latency to fire, increased the action potential half-width, and reduced action potential afterhyperpolarization, effects that are all consistent with negative modulation of potassium M-currents, that in the central nervous system are mainly carried out by Kv7/KCNQ-channels. Indeed, we found that the GPR158-induced increase in MSN excitability was associated with decreased M-current amplitude, and selective pharmacological inhibition of the M-current mimicked and occluded the effects of GPR158 activation. In addition, when the protein kinase A (PKA) or extracellular signal-regulated kinase (ERK) signaling was pharmacologically blocked, modulation of MSN excitability by GPR158 activation was suppressed. Moreover, GPR158 activation increased the phosphorylation of ERK and Kv7.2 serine residues. Collectively, our findings suggest that GPR158/PKA/ERK signaling controls MSN excitability via Kv7.2 modulation. Glycine-dependent activation of GPR158 may significantly affect MSN firing in vivo, thus potentially mediating specific aspects of goal-induced behaviors.
Virus neutralization assays for human respiratory syncytial virus using airway organoids
Authors: van Dijk Laura L.A. , Rijsbergen Laurine C. , Rubio Bruno Tello , Schmitz Katharina S. , Gommers Lennert , Comvalius Anouskha D. , Havelaar Alexander , van Amerongen Geert , Schepp Rutger , Lamers Mart M. , GeurtsvanKessel Corine H. , Haagmans Bart L. , van Binnendijk Rob , de Swart Rik L. , de Vries Rory D. 
Published: June 2024

AbstractNeutralizing antibodies are considered a correlate of protection against severe human respiratory syncytial virus (HRSV) disease. Currently, HRSV neutralization assays are performed on immortalized cell lines like Vero or A549 cells. It is known that assays on these cell lines exclusively detect neutralizing antibodies (nAbs) directed to the fusion (F) protein. For the detection of nAbs directed to the glycoprotein (G), ciliated epithelial cells expressing the cellular receptor CX3CR1 are required, but generation of primary cell cultures is expensive and labor-intensive. Here, we developed a high-throughput neutralization assay based on the interaction between clinically relevant HRSV grown on primary cells with ciliated epithelial cells, and validated this assay using a panel of infant sera. To develop the high-throughput neutralization assay, we established a culture of differentiated apical-out airway organoids (Ap-O AO). CX3CR1 expression was confirmed, and both F- and G-specific monoclonal antibodies neutralized HRSV in the Ap-O AO. In a side-by-side neutralization assay on Vero cells and Ap-O AO, neutralizing antibody levels in sera from 125 infants correlated well, although titers on Ap-O AO were consistently lower. We speculate that these lower titers might be an actual reflection of the neutralizing antibody capacity in vivo. The organoid-based neutralization assay described here holds promise for further characterization of correlates of protection against HRSV disease.
Ernährung, Stoffwechsel, Gehirn und mentale Gesundheit
Authors: Linsmayer Denise , Eckert Gunter P. , Reiff Julia , Braus Dieter F. 
Published: June 2024

ZusammenfassungDer Beitrag untersucht den komplexen Zusammenhang zwischen Ernährung, Stoffwechsel, Gehirnfunktion und mentaler Gesundheit. Er beleuchtet zwei zentrale, sich ergänzende Modelle – das Energiebilanzmodell und das Kohlenhydrat-Insulin-Modell –, um die Entstehung von Adipositas und metabolischen Dysfunktionen zu verstehen. Besondere Aufmerksamkeit wird zum einen der Rolle von Dopamin in der Ernährungsregulation und zum anderen von Insulin im Gehirn gewidmet, welche beide wesentlich an der Pathogenese neurodegenerativer und stressassoziierter psychischer Störungen beteiligt sind. Zudem wird die Bedeutung des Schlafes, der Ernährungsgewohnheiten wie beispielsweise medizinisch begleitete Kalorienrestriktion für mentale Gesundheit und das Konzept des „Brain Food“ beschrieben. Die Befunde verdeutlichen die Relevanz der Ernährungsmedizin für die Psychiatrie und Psychotherapie und der Berücksichtigung von Stoffwechselzuständen für die Prävention und Behandlung psychischer und neurodegenerativer Erkrankungen.
Effect of the glucagon-like peptide-1 (GLP-1) receptor agonist semaglutide on alcohol consumption in alcohol-preferring male vervet monkeys
Authors: Fink-Jensen Anders , Wörtwein Gitta , Klausen Mette Kruse , Holst Jens Juul , Hartmann Bolette , Thomsen Morgan , Ptito Maurice , Beierschmitt Amy , Palmour Roberta M. 
Published: June 2024

Abstract

Rationale
Glucagon-like peptide-1 (GLP-1) receptor agonists reduce alcohol consumption in rodents and non-human primates. Semaglutide is a new long-acting GLP-1 receptor agonist, widely used in the clinic against type 2 diabetes and obesity. It is also reported to reduce alcohol intake in rodents.

Objectives
This study investigates the possible inhibitory effect of semaglutide on alcohol intake in alcohol-preferring African green monkeys.

Methods
We performed a vehicle-controlled study on male monkeys that had demonstrated a preference for alcohol. In the monkeys selected for voluntary alcohol drinking, alcohol consumption was measured for ten days at baseline (Monday to Friday for two weeks). During this period, the monkeys had access to alcohol 4 h per day and free access to water 24 h per day. After two weeks of baseline measurements, the monkeys were randomized to semaglutide or vehicle. Each group consisted of ten monkeys, and the two groups were balanced with respect to baseline alcohol intake. Following the baseline period, the monkeys were treated with escalating doses of semaglutide (up to 0.05 mg/kg) or vehicle subcutaneously twice weekly for two weeks during which period alcohol was not available. After uptitration, the monkeys had access to alcohol 4 h daily for 20 days (Monday to Friday for 4 weeks), and alcohol consumption was measured. During this alcohol exposure period, treatment with semaglutide (0.05 mg/kg twice weekly) or vehicle continued for three weeks followed by a one-week washout period.

Results
Compared to the vehicle, semaglutide significantly reduced alcohol intake. There were no signs of emetic events or changes in water intake.

Conclusions
These data demonstrate for the first time the potent effect of semaglutide in reducing voluntary alcohol intake in non-human primates and further substantiate the need for clinical trials investigating the effect of semaglutide in patients with alcohol-use disorder.
Pureté de l’approximation forte sur le corps des fonctions d’une courbe algébrique complexe
Authors: Boughattas Elyes 
Published: June 2024

AbstractOver the function field of a complex algebraic curve, strong approximation off a non-empty finite set of places holds for the complement of a codimension 2 closed subset in a homogeneous space under a semisimple algebraic group, and for the complement of a codimension 2 closed subset in an affine smooth complete intersection of low degree.
The Homunculus of unspecific bone uptakes associated with PSMA-targeted tracers: a systematic review-based definition
Authors: Rizzo Alessio , Morbelli Silvia , Albano Domenico , Fornarini Giuseppe , Cioffi Martina , Laudicella Riccardo , Dondi Francesco , Grimaldi Serena , Bertagna Francesco , Racca Manuela , Treglia Giorgio , Bauckneht Matteo 
Published: June 2024

Abstract
Purpose
Prostate-Specific Membrane Antigen (PSMA)-targeted Positron Emission Tomography (PET) has revolutionised prostate cancer (PCa) diagnosis and treatment, offering superior diagnostic accuracy over traditional methods and enabling theragnostic applications. However, a significant diagnostic challenge has emerged with identifying unspecific bone uptakes (UBUs), which could lead to over-staging and inappropriate treatment decisions if misinterpreted. This systematic review explores the phenomenon of UBUs in PCa patients undergoing PSMA-PET imaging.

Methods
Studies assessing the prevalence, topographical distribution, and potential clinical implications of UBUs were selected according to the Preferred Reporting Items for a Systematic Review and Meta-Analysis (PRISMA) method and evaluated with the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool.

Results
The percentage of PCa patients with UBUs on PSMA-PET scans ranged from 0 to 71.7%, depending on the radiopharmaceutical used, with [18F]PSMA-1007 showing the highest incidence. The ribs are the primary site of UBUs across all PSMA-targeted radiopharmaceuticals. The spine is the second most frequent UBU site for [68Ga]Ga-PSMA-11, [18F]DCFPyL, [18F]rhPSMA-7, while the pelvic girdle represents the second most frequent site for [18F]PSMA-1007. The average maximum Standardized Uptake Value (SUVmax) of UBUs varied from 3.4 to 7.7 and was generally lower than that of bone metastases.

Conclusions
Our findings underscore the need for heightened awareness and precise interpretation of UBUs to avoid potential over-staging and subsequent inappropriate treatment decisions. Considering the radiopharmaceutical used, PET-derived semiquantitative parameters, the topographical distribution of UBUs, and accurately evaluating the pre-test probability based on clinical and laboratory parameters may aid nuclear medicine physicians in interpreting PSMA-PET findings.
Occasional and constant exposure to dietary ethanol shortens the lifespan of worker honey bees
Authors: Ostap-Chec Monika , Bajorek Daniel , Antoł Weronika , Stec Daniel , Miler Krzysztof 
Published: June 2024

AbstractHoney bees (Apis mellifera) are one of the most crucial pollinators, providing vital ecosystem services. Their development and functioning depend on essential nutrients and substances found in the environment. While collecting nectar as a vital carbohydrate source, bees routinely encounter low doses of ethanol from yeast fermentation. Yet, the effects of repeated ethanol exposure on bees’ survival and physiology remain poorly understood. Here, we investigate the impacts of constant and occasional consumption of food spiked with 1% ethanol on honey bee mortality and alcohol dehydrogenase (ADH) activity. This ethanol concentration might be tentatively judged close to that in natural conditions. We conducted an experiment in which bees were exposed to three types of long-term diets: constant sugar solution (control group that simulated conditions of no access to ethanol), sugar solution spiked with ethanol every third day (that simulated occasional, infrequent exposure to ethanol) and daily ethanol consumption (simulating constant, routine exposure to ethanol). The results revealed that both constant and occasional ethanol consumption increased the mortality of bees, but only after several days. These mortality rates rose with the frequency of ethanol intake. The ADH activity remained similar in bees from all groups. Our findings indicate that exposure of bees to ethanol carries harmful effects that accumulate over time. Further research is needed to pinpoint the exact ethanol doses ingested with food and exposure frequency in bees in natural conditions.
Fast and precise approximation of Minkowski sum of two rotational ellipsoids with a superellipsoid
Authors: Yamada Ryunosuke , Tsuji Tokuo , Hiramitsu Tatsuhiro , Seki Hiroaki , Nishimura Toshihiro , Suzuki Yosuke , Watanabe Tetsuyou 
Published: June 2024

AbstractIn this paper, we propose a fast and accurate method for approximating the Minkowski sum of two rotational ellipsoids with a superellipsoid. The Minkowski sum is used in a variety of applications such as robot motion planning and particle flow simulation requiring collision detection. Many of them are computed based on Minkowski sum, whose accuracy and processing time depend on how the mesh is created. We approximate Minkowski sum with a superellipsoid function. The superellipsoid has various shapes with the value of the exponents, and the computation of the parameters including the exponents is an algebraic computation with the time complexity $$\varvec{O}(1)$$

O

(
1
)

. As a result, approximation error is small and computation is fast in all combinations of rotational ellipsoids. In addition, collision is quickly detected by solving the inequality of superellipsoid.
No evidence for effects of low-intensity vestibular noise stimulation on mild-to-moderate gait impairments in patients with Parkinson’s disease
Authors: Peto Daniela , Schmidmeier Florian , Katzdobler Sabrina , Fietzek Urban M. , Levin Johannes , Wuehr Max , Zwergal Andreas 
Published: June 2024

Abstract
Background
Gait impairment is a key feature in later stages of Parkinson’s disease (PD), which often responds poorly to pharmacological therapies. Neuromodulatory treatment by low-intensity noisy galvanic vestibular stimulation (nGVS) has indicated positive effects on postural instability in PD, which may possibly be conveyed to improvement of dynamic gait dysfunction.

Objective
To investigate the effects of individually tuned nGVS on normal and cognitively challenged walking in PD patients with mild-to-moderate gait dysfunction.

Methods
Effects of nGVS of varying intensities (0–0.7 mA) on body sway were examined in 32 patients with PD (ON medication state, Hoehn and Yahr: 2.3 ± 0.5), who were standing with eyes closed on a posturographic force plate. Treatment response and optimal nGVS stimulation intensity were determined on an individual patient level. In a second step, the effects of optimal nGVS vs. sham treatment on walking with preferred speed and with a cognitive dual task were investigated by assessment of spatiotemporal gait parameters on a pressure-sensitive gait carpet.

Results
Evaluation of individual balance responses yielded that 59% of patients displayed a beneficial balance response to nGVS treatment with an average optimal improvement of 23%. However, optimal nGVS had no effects on gait parameters neither for the normal nor the cognitively challenged walking condition compared to sham stimulation irrespective of the nGVS responder status.

Conclusions
Low-intensity nGVS seems to have differential treatment effects on static postural imbalance and continuous gait dysfunction in PD, which could be explained by a selective modulation of midbrain-thalamic circuits of balance control.