bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Involvement of TLR2-NF-κB Pathway and Acupoint Sensitization in Acupuncture for Improving the Neurological Function in Rats with the Intracerebral Hemorrhage
Authors: Li Lu , Han Dexiong , Zhang Quanai , Zhou Chuanlong , Wang Chao , Liu Yingjun 
Published: April 2024

Abstract

Acupoints are both the sensory points and reaction points of organ physiological functions and pathological changes. The stimulation from needles on acupoints have been proved to improve the symptoms of various diseases, especially Intra-cerebral Hemorrhage (ICH). Herein, the effect of acupuncture on the toll-like receptor signaling pathway and the role of acupoint sensitization in ICH are discussed. A rat model of ICH was induced by infusing autologous blood into the caudate nucleus. Acupuncture was performed after ICH once a day for 30 min. On the 1st, 3rd, and 7th day of acupuncture, the Neurological Deficit Scale (NDS), blood-brain barrier (BBB) permeability, and the levels of IL-1β, IL-6, TNF-α, c-Jun, c-Fos, p-c-Jun, p-c-Fos, TLR2 were observed. Compared with the sham group, the levels of IL-1β, IL-6, TNF-α, and TLR2 noticeably increased, but not the levels of c-Jun, c-Fos, p-c-Jun, p-c-Fos. Compared with the ICH model group, the levels of IL-1β, IL-6, TNF-α in the acupoint treated with simvastatin or acupuncture were reduced, and the same phenomenon were observed in p-c-Jun, p-c-Fos, TLR2, MCP-1 in the local acupoints. The results indicated that acupuncture could recover the BBB, neurological function, and reduce the levels of inflammation and mast cells (MCs) degranulation in ICH rats. In short, acupuncture at ST36 can effectively improve the NDS and open the BBB in ICH rats, which may be related to down-regulation of IL-1β, IL-6, TNF-α, TLR2, and MCs degranulation, but no close relationship was found with the functions of c-Fos/c-Jun.
Investigation of innovation as a condition for the country's level of economic complexity: an international Empirical approach
Authors: Araujo Breno Valente Fontes , Azevedo Ana Claudia , Ferreira Marco Aurélio Marques 
Published: April 2024

Abstract

This study assessed how national innovation systems (NIS) conditioning pillars influence countries' economic complexity levels. To this end, multivariate statistical analysis was applied, with the multiple linear regression technique, to the data collected from the Global Innovation Index (GII) and Economic Complexity Index (ECI) bases, from 112 different countries, with the year 2020 as reference. As a result, there was a significant and positive relationship between the Infrastructure and Business Sophistication pillars. In contrast, the Institutions, Human Capital, and Research and Market Sophistication pillars did not directly influence the ECI. This study contributes to the literature by exploring, in an objective way (quantitative study), a field of investigation of the pillars of national innovation that impact the economic complexity of nations and indicates paths to be followed by actors who participate in the dynamics of national innovation systems to create a national plan that enables more significant levels of economic complexity and consequent development.
JEL code: C21, C43, O31, O38, O57
Fidelity of Health Care Providers on Adhering to Guidelines for Managing Neonates With Respiratory Distress Using Silverman Anderson Severity (Sas) Score Tool in Limited Resource Settings: A Case Study at Amana Regional Referral Hospital
Authors: Shayo- Fredrick , Kessy- Anna , Amour- Maryam 
Published: April 2024

Abstract

Background: This case study was conducted at Amana Regional Referral Hospital, a referral hospital of Ilala District in Dar es Salaam Region Tanzania. The aim is to assess the adherence of healthcare providers to guidelines when providing health services to neonates with respiratory distress and how supportive the health system is in limited resource settings.
Methods: It was a case study that used a qualitative approach to data collection and analysis. A total of 16 participants did participate in this study of which the sample size was reached by the principle of information saturation. The study population was healthcare providers (pediatricians, general medical doctors, and nurses) working in the neonatal ward who were selected purposively depending on their experience in the neonatal ward. In-depth interviews (IDI) and an observation checklist were used for data collection from key informants and content analysis was used to analyze the data.
Results: The findings revealed that healthcare providers did not fully adhere to the guidelines when managing neonates with respiratory distress. The Silverman-Anderson Severity (SAS) score tool is of use to asses the neonate’s respiratory distress status. It is used for decision-making in prioritizing neonates to Continuous Positive Airway Pressure (CPAP) and monitoring them. They did know the use of the SAS score tool, which was even posted in the ward they are working in for them to follow but yet they showed partial adherence to use it. While healthcare providers displayed partial adherence, various challenges within the health system negatively impacted their consistent adherence. Factors such as understaffing, inadequate training, a shortage of CPAP machines, heavy workloads, and lack of motivation emerged as significant deterrents to adherence. These challenges hindered proper monitoring, documentation, and decision-making processes for CPAP initiation and monitoring.
Conclusion: The conclusion of the study highlights that healthcare providers at Amana Regional Referral Hospital demonstrated partial adherence to guidelines for managing neonates with respiratory distress, particularly in the consistent use of the Silverman Anderson Severity (SAS) score tool. Despite awareness of the tool and its importance, challenges such as understaffing, inadequate training, and a shortage of CPAP machines hindered full adherence. Addressing these challenges, including improving staffing, offering comprehensive training, and ensuring equipment availability, is crucial for enhancing adherence and improving neonatal care in resource-limited settings.
Cobalt layer prepared on copper using galvanic replacement as an alternative to palladium for activating electroless Ni-P plating
Authors: Hu Guanqun , Li Rupeng , Liao Wanda , Bai Changning , Zhang Xingkai , Zhao Qiuping , Zhang Junyan 
Published: April 2024

Abstract

Electroless nickel-phosphorus (Ni-P) plating is a widely used surface treatment method due to its excellent corrosion and wear resistance properties. However, the inertness of copper to hypophosphite oxidation necessitates a palladium activation process for the preparation of Ni-P coating on copper. In this study, we present a convenient approach for the deposition of a cobalt layer on copper using galvanic replacement, facilitated by the special complexing ability of iodide. The results demonstrated that the actual potential of copper could be adjusted to be lower than that of cobalt in a solution containing 8 mol/L NaI, enabling the deposition of a cobalt layer on copper in 15 minutes at 90°C. Furthermore, the deposition rate of the cobalt layer was found to increase with the concentration of CoCl2 in the NaI solution. Importantly, the Ni-P coating obtained through cobalt layer activation exhibited morphology, structure, and corrosion resistance, friction resistance similar to the Ni-P coating obtained using the common palladium activation. Therefore, the cobalt layer prepared on copper through galvanic replacement may serve as a viable alternative to palladium for activating electroless Ni-P plating.
Global transcriptomic analysis reveals CYP1A1 as a target of the GPER agonist G1
Authors: Hatwik Juana , Pal Uttariya , Manjegowda Mohan C. , Limaye Anil Mukund 
Published: April 2024

Abstract

Background: G1, a G-protein coupled estrogen receptor (GPER) agonist, has been instrumental in delineating the mechanisms and cellular consequences of GPER signal transduction. The effects of G1 on cell proliferation are controversial, including those that are demonstrably GPER-independent. It begs the question as to whether G1 has off-target effects.
Methods and Results: Here, transcriptomic alterations in MCF-7 breast cancer cells treated with 1 mM G1 are presented. GSEA and GO analysis showed enrichment of gene-sets in G1-treated MCF-7 transcriptome, which align with loss of cell viability. Genes related to xenobiotic metabolism were regulated by G1. In this category, CYP1A1, was the topmost G1-induced gene. CH223191, an aryl hydrocarbon receptor inhibitor, blocked G1-mediated increase in CYP1A1 mRNA. Furthermore, the G1-mediated modulation of CYP1A1, and other genes, was also observed in the GPER-negative MDA-MB-453 cells.
Conclusions: This study captures the transcriptomic alterations associated with G1-induced cell cycle arrest in MCF-7 cells, with the important caveat that these may not be entirely attributed to GPER activation.
Uveal Melanoma zebrafish xenograft models illustrate the mutation status-dependent effect of compound synergism or antagonism
Authors: Bosch Quincy van den , Kilic Emine , Brosens Erwin 
Published: April 2024

Abstract

Purpose
Uveal melanoma (UM) is the most common primary intraocular malignancy with a high probability of metastatic disease. Although excellent treatment option for primary UM are available, therapy for metastatic disease remain limited. Drug discovery studies using mouse models have thus far failed to provide therapeutic solutions, highlighting the need for novel models. Here, we optimize zebrafish xenografts as a potential model for drug discovery by showcasing the behavior of multiple cell lines and novel findings on mutation-dependent compound synergism/antagonism using Z-Tada; an algorithm to objectively characterize output measurements.
Methods
Prognostic relevant primary and metastatic UM cell lines or healthy melanocytes were inoculated at three distinct inoculation sites. Standardized quantifications independent of inoculation site were obtained using Z-Tada; an algorithm to measure tumor burden and the number, size and distance of disseminated tumor cells. Sequentially, we utilized this model to validate combinatorial synergism or antagonism seen in vitro.
Results
Detailed analysis of 691 zebrafish xenografts demonstrated perivitelline space inoculation provided robust data with high probability of cell dissemination. Cell lines with more invasive behavior (SF3B1mut and BAP1mut) behaved most aggressive in this model. Combinatorial drug treatment illustrated synergism or antagonism is mutation-dependent, which were confirmed in vivo. Combinatorial treatment differed per xenograft-model, as it either inhibited overall tumor burden or cell dissemination.
Conclusion
Perivitelline space inoculation provides robust zebrafish xenografts with the ability for high-throughput drug screening and robust data acquisition using Z-Tada. This model demonstrates that drug discovery for uveal melanoma must take mutational subclasses into account, especially in combinatorial treatment discoveries.
Intermediate pyrolysis of hazelnut shell: temperature effect on energy conversion and products characteristics
Authors: Bartolucci Lorenzo , Cordiner Stefano , Kumar Gopalakrishnan , Mele Pietro , Mulone Vincenzo 
Published: April 2024

Abstract

Residual biomass is a renewable and clean energy source that is expected to play a crucial role in the energy transition. Thermochemical valorization of agro-industrial waste represents a promising alternative, which is still requiring further investigation with regard to the economical sustainability. In this study, intermediate pyrolysis of hazelnut shell was performed employing a laboratory scale screw-type reactor, evaluating the impact of temperature on the mass and energy flows of the process. The results show that temperature has a significant impact on the liquid and non-condensable gas yields, whilst biochar yield remains stable in the range of 18-23 w/w %. Pyrolysis condensates spontaneously split into organic and aqueous fractions and have calorific value of 18.1-18.5 MJ/kg and 1.9-3.2 MJ/kg, respectively. GC-MS analysis revealed that aromatic compounds dominate the organic fraction, while acetic acid is very abundant in the water-phase (125-147 g/L), suggesting attracting the potential recovery of chemicals. The carbon conversion efficiency for intermediate pyrolysis is around 90% and the theoretical energy recovery ratio is maximized at 76.6 % at 500 ° C. Moreover, the energy recovery ratio is rather high 72-76 % in the temperature range explored, showing that intermediate pyrolysis may adapt effectively to changes in temperature.
One Adult Patient with Streptococcus gallolyticus Meningitis Complicated by Infective Endocarditis: A Case report
Authors: XIE PAILING , YUAN SHUAISHUAI , Liu Fenqing , Lian Subing 
Published: April 2024

Abstract

We present a nursing experience of an adult patient who underwent aortic valve replacement due to streptococcus gallolyticus meningitis as the first symptom, which was complicated by infective endocarditis (IE). Multidisciplinary treatment was initiated to address nursing issues such as high fever, poor cardiac function, postoperative anticoagulation, and cognitive and speech impairment. Specific nursing measures were implemented, including infection control and treatment, mental assessment, monitoring of cardiac function, airway management after heart failure intensifies, individualized anticoagulation, cognitive training, and rehabilitation exercises. The patient underwent a successful aortic valve replacement and was transferred to the general ward on the 12th day after surgery. he was discharged on the 56th day.
Insider imitation with product differentiation
Authors: d'Andria Diego 
Published: April 2024

Abstract

Online marketplace providers such as Amazon may also offer own-brand products, thus competing with third-party traders on their platform. Moreover they may exploit nonpublic data on third-party sales to identify opportunities for profit and design their own products, in this way engaging in a form of partial imitation that is exclusive to them. Such an asymmetry in the ability to imitate has led to advocating for stricter regulation of online platforms in order to limit their ability to exploit nonpublic data. We propose a dynamic simulation model to study the effects of insider imitation by a platform provider under product differentiation. Using different parametrizations, we are able to show how such a market may evolve in time with or without the presence of insider imitation under different initial conditions. The model also allows to account for subsequent innovation via imitation, which is an aspect not considered by previous studies. Our results add to the existing literature and casts further doubts on current regulatory approaches aiming at limiting data exploitation. Our results suggest that the presence of insider imitation is more likely to lead to higher consumer welfare and lower market concentration and should not be banned on the grounds of standard Antitrust concerns.
JEL Classifications: D40, D82, D83, L40, O3
Chromatic tuning of exciton state in MoS2 monolayer via tailoring Moiré correlation with a sapphire substrate
Authors: Chan Chun-Wen , Yang Kun-Xiang , Chen Lu-Chih , Chan Fang-Mei , Chiu Sheng-Kuei , Yang Chao-Yao 
Published: April 2024

Abstract

This study attempts to elucidate the specific Moiré correlation and associated exciton properties within MoS2 monolayers randomly orientated grown on a c-cut single-crystalline sapphire substrate, facilitating a distinct Moiré correlation. Notably, the energy of the exciton state in MoS2 monolayers appears periodically linked to the stacking geometry with the sapphire substrate. Specifically, coherent stacking as observed in MoS2[110]/sapphire[110] configurations results in heightened exciton energy, while 30-degree-misaligned stacking such as MoS2[110]/sapphire[010] yields lower exciton energy. The variation in exciton energy, consequent to alterations in the stacking geometry between MoS2 and sapphire, thus exhibits a 6-fold periodicity, reflective of the hexagonal nature of both MoS2 and sapphire. Furthermore, the exciton state originating from the 30-degree-misaligned correlation emerges as an electronic destination upon aging MoS2 monolayers on sapphire, leading to a cessation of the 6-fold periodicity and a subsequent decline in exciton energy. This study underscores the potential for manipulating the crystallographic stacking between single-crystalline MoS2 monolayers and sapphire substrates to serve as a versatile platform for investigating photonics in the MoS2-based heterostructures.
Extracting work from multiqubit-interacting system coupled to a common environment
Authors: Hadipour Maryam , Haseli Soroush 
Published: April 2024

Abstract

We consider the task of extracting work from multiqubit-interaction system coupled to a common non-Markovian environment. By adjusting various parameters such as the number of qubits and the strength of interaction between qubits, the environment can be made non-Markovian in both strong coupling and weak coupling states. It will be shown that the number of qubits and the coupling strengthbetween the qubits have a positive role for enhancing the process of extracting work from the quantum system.
IFRD2 regulates myogenic differentiation of bovine skeletal muscle satellite cells through the ERK1/2 pathway
Authors: Gong Zhian , zhang Xiaoyu , Cui Jingxuan , Chen Wen , Huang Xin , Yang Qingzhu , Li Tie , Zhang Weiwei 
Published: April 2024

Abstract

The proliferation and differentiation of skeletal muscle satellite cells is a complex physiological process in which many transcription factors and small RNA molecules are involved. In this study, interferon-related development factor 2 (IFRD2) was identified as a target gene of bta-miRNA-2400 involved in regulating the proliferation and differentiation of bovine skeletal MDSCs (Muscle-derived satellite cells, MDSCs). The results indicate that bta-miR-2400 can target bind the 3'UTR of IFRD2 and inhibit its translation. mRNA and protein expression levels of IFRD2 increased significantly with increasing days of differentiation. Overexpression of the IFRD2 gene inhibited the proliferation and promoted the differentiation of bovine MDSCs. Conversely, the knockdown of the gene had the opposite effect. Overexpression of IFRD2 resulted in the inhibition of ERK1/2 phosphorylation levels in bovine MDSCs, which in turn promoted differentiation. In summary, IFRD2, as a target gene of bta-miR-2400, affects bovine skeletal muscle proliferation and differentiation by regulating ERK1/2 phosphorylation.
Examining the influence of industrial growth, renewable energy consumption, and the financial development index on CO 2 emissions: Empirical insights from OECD countries
Authors: Dallali Atef , Jebli Mehdi Ben , Hasni Radhouane 
Published: April 2024

Abstract

The increase in carbon dioxide (CO2) emissions has precipitated a climate crisis, with the industrial sector identified as a significant contributor to escalating pollution levels. This research explores the impact of real gross domestic product (GDP), consumption of renewable and non-renewable energy (RE, NRE), financial development (FD), and industrial value added (IVA) on CO2 emissions across a panel of OECD countries spanning the period 2000–2021. Cointegration techniques are employed to achieve this objective. The findings of the empirical analysis reveal cross-sectional dependence among countries. Furthermore, the variables are found to be integrated of order one, and cointegration tests indicate the presence of a long-run relationship between them. The results obtained from the fully modified ordinary least squares (FMOLS) analysis indicate that economic growth and non-renewable energy consumption are associated with an increase in CO2 emissions. In contrast, renewable energy consumption, industrial value-added, and financial development are found to contribute to a reduction in emissions over the long term. The interaction between financial development and industrial value-added exhibits a positive influence on CO2 emissions, indicating a lack of alignment between financial and industrial strategies.
Interface-driven structural evolution on diltiazem as novel uPAR inhibitors: From in silico design to in vitro evaluation
Authors: Xie Song , Zhou Yang , Zhu Hao , Xu Xinyi , Zhang Han , Yuan Cai , Huang Mingdong , Xu Peng , Li Jinyu , Liu Yichang 
Published: April 2024

Abstract

The urokinase-type plasminogen activator receptor (uPAR) emerges as a key target for anti-metastasis owing to its pivotal role in facilitating the invasive and migratory processes of cancer cells. Recently, we identified the uPAR-targeting anti-metastatic ability of diltiazem (22), a commonly used antihypertensive agent. Fine-tuning the chemical structures of known hits represents a vital branch of drug development. To develop novel anti-metastatic drugs, we performed an interface-driven structural evolution strategy on 22. The uPAR-targeting and anti-cancer abilities of this antiphypertenisve drug was identified by us recently. Based on in-silico strategy, including extensive molecular dynamics (MD) simulations, hierarchical binding free energy predictions, and ADMET profilings, we designed, sythesized and identified three new diltiazem derivatives (221-8, 221-57, and 221-68) as uPAR inhibitors. Indeed, all of these three derivatives exhibited uPAR-depending inhibitory activity against PC-3 cell line invasion at micromolar level. Particularly, derivatives 221-68 and 221-8 showed enhanced uPAR-dependent inhibitory activity against the tumor cell invasion compared to the original compound. Microsecond timesclae MD simulations demonstrated the optimized moiety of 221-68 and 221-8 forming more comprehensive interactions with the uPAR, highlighting the reasonbility of our stragy. This work introduces three novel uPAR inhibitors, which not only paves the way for the development of effective anti-metastatic therapeutics, but also emphasizes the efficacy and robustness of an in silico-based lead compound optimization strategy in drug design.
Experimental and analytical research on geopolymer concrete beams reinforced with GFRP bars
Authors: Adakli Suleyman Anil , Tokgoz Serkan , Karaahmetli Sedat , Dundar Cengiz 
Published: April 2024

Abstract

This paper presents the behavior of geopolymer concrete beams reinforced with glass fiber reinforced polymer (GFRP) bars. In the study, ordinary Portland cement concrete and geopolymer concrete beams having GFRP bars were prepared and tested under four-point loading. The load-deflection diagrams and load capacities of the tested beams were obtained. It was observed that the tested beams exhibited good ductility and significant deflection capacity. The results showed that increasing the tension GFRP reinforcement ratio caused enhancement in the strength capacity of geopolymer concrete beams. In addition, the tested beams were analyzed for load capacity and load-deflection responses. The theoretical load‒deflection curves and load bearing capacities have been predicted well with the test results. Parametric study has been performed to determine the influences of concrete strength, shear span to depth ratio (a/d) and reinforcement ratio on the behavior of geopolymer concrete beams longitudinally reinforced with GFRP bars. It was concluded that increasing concrete strength and reinforcement ratio led to an increase in load capacity, and increasing a/d ratio reduced the ultimate load value of GFRP reinforced geopolymer concrete beams.