bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding the expansion of social control and helping professionals as unwilling agents of the state: The passing of the Child Abuse Prevention and Treatment Act in the United States
Authors: Williams-Butler Abigail , Cunningham Shari , Gandarilla Ocampo María , Golden Guzman Kate , Mendez Alicia 
Published: May 2024

Abstract
It is widely known that those in the helping professions are mandated to report suspected incidences of child maltreatment. However, few are aware of the historical resistance to mandated reporting that helping professionals demonstrated before the passing of the Child Abuse Prevention and Treatment Act (CAPTA) of 1974 and the associated federal mandates that compelled helping professionals to engage in mandated reporting, oftentimes against their will. By analysing historical policy documents through a grounded theory approach, the authors identified three themes that describe the rationale for the passage of CAPTA: (1) identifying national evidence of child abuse; (2) resistance to intrusion of the helping professional-client relationship; and (3) the necessity of immunity waivers for those who reported instances of child abuse and misdemeanor punishment for those who failed to report such instances. In light of conversations around abolishing or reforming child protective services, it is important to understand how the first federal child protective services policy in the United States originated and how these regulations embedded social control into the foundation of the helping professional-client relationship, thus turning helping professionals into unwilling agents of the state. Implications of mandated reporting, including introducing a penal aspect to the helping professional-client relationship, are also explored.
Vision-based adaptive LT sliding mode admittance control for collaborative robots with actuator saturation
Authors: Huang Cong , Zhu Minglei , Song Shijie , Zhao Yuyang , Jiang Jinmao 
Published: May 2024

AbstractIn this paper, we propose a novel vision-based adaptive leakage-type (LT) sliding mode admittance control for actuator-constrained collaborative robots to realize the synchronous control of the precise path following and compliant interaction force. Firstly, we develop a vision-admittance-based model to couple the visual feedback and force sensing in the image feature space so that a reference image feature trajectory can be obtained concerning the contact force command and predefined trajectory. Secondly, considering the system uncertainty, external disturbance, and torque constraints of collaborative robots in reality, we propose an adaptive sliding mode controller in the image feature space to perform precise trajectory tracking. This controller employs a leakage-type (LT) adaptive control law to reduce the side effects of system uncertainties without knowing the upper bound of system uncertainties. Moreover, an auxiliary dynamic is considered in this controller to overcome the joint torque constraints. Finally, we prove the convergence of the tracking error with the Lyapunov stability analysis and operate various semi-physical simulations compared to the conventional adaptive sliding mode and parallel vision/force controller to demonstrate the efficacy of the proposed controller. The simulation results show that compared with the controller mentioned above, the path following accuracy and interaction force control precision of the proposed controller increased by 50% and achieved faster convergence.
Co-designing versatile quadruped robots for dynamic and energy-efficient motions
Authors: Fadini Gabriele , Kumar Shivesh , Kumar Rohit , Flayols Thomas , Del Prete Andrea , Carpentier Justin , Souères Philippe 
Published: May 2024

AbstractThis paper presents a concurrent optimization approach for the design and motion of a quadruped in order to achieve energy-efficient cyclic behaviors. Computational techniques are applied to improve the development of a novel quadruped prototype. The scale of the robot and its actuators are optimized for energy efficiency considering the complete actuator model including friction, torque, and bandwidth limitations. This method and the optimal bounding trajectories are tested on the first (non-optimized) prototype design iteration showing that our formulation produces a trajectory that (i) can be easily replayed on the real robot and (ii) reduces the power consumption w.r.t. hand-tuned motion heuristics. Power consumption is then optimized for several periodic tasks with co-design. Our results include, but are not limited to, a bounding and backflip task. It appears that, for jumping forward, robots with longer thighs perform better, while, for backflips, longer shanks are better suited. To explore the tradeoff between these different designs, a Pareto set is constructed to guide the next iteration of the prototype. On this set, we find a new design, which will be produced in future work, showing an improvement of at least 52% for each separate task.
BinaryTech in motion: The sexgender in the European Court of Human Rights jurisprudence
Authors: Aalto Juho 
Published: May 2024

AbstractSexgender has become politicized by neo-conservative and populist movements in Europe and elsewhere. This article explores how the sexgender binary is foundational to the social and material construction of the non-heterosexual legal subject and unveils binary hierarchies embedded therein. Furthermore, it develops a new materialist methodology called BinaryTech, which exposes the binary formulas of inequality and difference in the Court’s jurisprudence. This new materialist approach, based on Karen Barad’s agential realism, is used to critically examine how differences are produced as stable features of subjects and objects. The human of the Convention being heterosexual is thereby the result, constructed on material-discursive differentiation of non-heterosexuals. The article concludes by describing how new materialist interventions and Nordic feminist perspectives on law can offer valuable insights within the emerging material turn.
Impacts of environmental factors on the aetiological diagnosis and disease severity of community-acquired pneumonia in China: a multicentre, hospital-based, observational study
Authors: Zhang Yichunzi , Li Jiang , Wu Chao , Xiao Yan , Wang Xinming , Wang Ying , Chen Lan , Ren Lili , Wang Jianwei 
Published: May 2024

Abstract
Environmental exposures are known to be associated with pathogen transmission and immune impairment, but the association of exposures with aetiology and severity of community-acquired pneumonia (CAP) are unclear. A retrospective observational study was conducted at nine hospitals in eight provinces in China from 2014 to 2019. CAP patients were recruited according to inclusion criteria, and respiratory samples were screened for 33 respiratory pathogens using molecular test methods. Sociodemographic, environmental and clinical factors were used to analyze the association with pathogen detection and disease severity by logistic regression models combined with distributed lag nonlinear models. A total of 3323 CAP patients were included, with 709 (21.3%) having severe illness. 2064 (62.1%) patients were positive for at least one pathogen. More severe patients were found in positive group. After adjusting for confounders, particulate matter (PM) 2.5 and 8-h ozone (O3-8h) were significant association at specific lag periods with detection of influenza viruses and Klebsiella pneumoniae respectively. PM10 and carbon monoxide (CO) showed cumulative effect with severe CAP. Pollutants exposures, especially PM, O3-8h, and CO should be considered in pathogen detection and severity of CAP to improve the clinical aetiological and disease severity diagnosis.
Bishops in the House of Lords: fit for the future?
Authors: Hatcher Mark 
Published: May 2024

AbstractThis article seeks to provide a constitutional law perspective on the contribution of the Lords Spiritual to the scrutiny of legislation in the House of Lords. It examines the legal basis of the bishops’ role in the Upper House and how this has evolved. It considers how far the bishops currently meet expectations about their role against the background of calls for reform of the House of Lords and changes in religious affiliation in the United Kingdom. The paper draws, amongst other things, on the experience of a group of current and former Lords Spiritual who shared their views with the author in the course of some informal semi-structured conversations. It also examines the relationship between the Lords Spiritual and the Church of England's national institutions. It concludes that the Lords Spiritual make a distinctive contribution to the legislature which should be maintained, with some modifications to meet the needs of the time.
Archbishop of Uganda v Joyce and Others
Authors: Cranmer Frank 
Published: May 2024

In April 2023, the House of Bishops of the Province of the Church of Uganda elected Canon Godfrey Kasana as Bishop of Luwero. Before his consecration could take place, however, a member of the church submitted a petition alleging that he was unsuitable for consecration on grounds of adultery – and in June the House of Bishops revoked his nomination. The respondents, in effect, sought judicial review of that decision, while the Archbishop argued that the claim was brought against the wrong party and was frivolous, vexatious and an abuse of process.
Detection and prebiotic chemistry of possible glycine precursor molecule methylenimine towards the hot molecular core G10.47+0.03
Authors: Manna Arijit , Pal Sabyasachi 
Published: May 2024

Abstract
Amino acids are essential for the synthesis of protein. Amino acids contain both amine (R–NH2) and carboxylic acid (R–COOH) functional groups, which help to understand the possible formation mechanism of life in the universe. Among the 20 types of amino acids, glycine (NH2CH2COOH) is known as the simplest non-essential amino acid. In the last 40 years, all surveys of NH2CH2COOH in the interstellar medium, especially in the star-formation regions, have failed at the millimetre and sub-millimetre wavelengths. We aimed to identify the possible precursors of NH2CH2COOH, because it is highly challenging to identify NH2CH2COOH in the interstellar medium. Many laboratory experiments have suggested that methylenimine (CH2NH) plays a key role as a possible precursor of NH2CH2COOH in the star-formation regions via the Strecker synthesis reaction. After spectral analysis using the local thermodynamic equilibrium (LTE) model, we successfully identified the rotational emission lines of CH2NH towards the hot molecular core G10.47+0.03 using the Atacama Compact Array (ACA). The estimated column density of CH2NH towards G10.47+0.03 is (3.40 ± 0.2) × 1015 cm−2 with a rotational temperature of 218.70 ± 20 K, which is estimated from the rotational diagram. The fractional abundance of CH2NH with respect to H2 towards G10.47+0.03 is 2.61 × 10−8. We found that the derived abundance of CH2NH agree fairly well with the existing two-phase warm-up chemical modelling abundance value of CH2NH. We discuss the possible formation pathways of CH2NH within the context of hot molecular cores, and we find that CH2NH is likely mainly formed via neutral–neutral gas-phase reactions of CH3 and NH radicals towards G10.47+0.03.
Genetic diversity in safflower (Carthamus tinctorius L.) germplasm for vegetative and agronomic characteristics in semi-arid regions
Authors: Sabaghnia Naser , Ahadnezhad Amin , Janmohammadi Mohsen 
Published: May 2024

AbstractSafflower, a semiarid crop, contains a healthy oil with high unsaturated fatty acids. Genetically diverse accessions are important for genetic maintenance of safflower and breeding proposes. The objectives of present investigation were to evaluate the morphological variation of 100 safflower accessions across two years (2022 and 2023), to explore similar genotypic groups and to identify the higher contribution of traits with to the observed variability. The highest coefficient of variation (CV) was observed for seeds per secondary capitulum, number of capitula per plant and weight of lateral capitulum in the first year and the highest CV values were observed for number of capitula per plant and capitula per lateral branch in the second year. The factor analysis identified five factors in the first year and six factors in the second as yield components, height, seed yield, capitulum diameter and phonology while number of branches was identified as the extra factor in the second year. Results showed that the variation of morphologic traits was made up of from the most measured traits of safflower. We defined seven distinct clusters, which made it possible to differentiate safflower accessions based on measured traits across two years. Of 45 accessions were grouped in similar clusters across two years, without any or similar genotype by environment interaction. Some high yielding accessions like C-47 and Lesaf-175 can be entered directly in multi-environmental trials for cultivar release proposes. The recognized variation improves as a good resource, indicating an important issue for future projects for safflower germplasm maintenance and breeding.
A New Type of Jovian Hectometric Radiation Powered by Monoenergetic Electron Beams
Authors: Collet B. , Lamy L. , Louis C. K. , Zarka P. , Prangé R. , Louarn P. , Kurth W. S. , Allegrini F. 
Published: May 2024

AbstractIn this study, we statistically analyze the Jovian auroral radio sources detected in situ by Juno/Waves at frequencies f below the electron cyclotron frequency fce. We first conduct a survey of Juno/Waves data over 1–40 MHz from 2016 to 2022. The 15 detected HectOMetric (HOM) sources all lie within 1–5 MHz and are both less frequent than the radio sources commonly observed slightly above fce and clustered in the southern hemisphere, within ∼90–270° longitudes. We analyze these emission regions with a growth rate analysis in the framework of the Cyclotron Maser Instability (CMI), which we apply to JADE‐E high cadence electron measurements. We show that the f < fce emissions correspond to crossed radio sources, ∼300 km wide. They are located in a hot and highly depleted auroral plasma environment, along flux tubes colocated with upward field‐aligned current and at the equatorward edge of the main auroral oval. The wave amplification is consistent with the CMI and its free energy source consists of a shell‐type electron distribution function (EDF) with characteristic energies of 0.2–5keV. More energetic, 5–50 keV, shell‐type EDFs were systematically observed at higher latitudes but without any radio counterpart. Various parameters for the f < fce HOM sources, reminiscent of the ones at Earth/Saturn, are compared. Other CMI‐unstable EDFs, primarily loss cone ones, are systematically observed during the same intervals, giving rise to emission observed at fce < f < fce + 0.5%. Our analysis thus reveals that different portions of the same EDF can be CMI‐unstable and simultaneously amplify radio waves below and above fce.
Immediate fortification of human milk with a bovine milk-derived human milk fortifier in very low birth weight infants: a randomized clinical trial
Authors: Wynter Zanna , Gorham Jane Anne , Thompson Amy B. , Mundy Cynthia , Waller Jennifer L. , Stansfield Brian K. 
Published: May 2024

Abstract
Objective
Double-blind randomized control trial of early addition of a bovine milk-derived human milk fortifier (HMF) in very low birth weight (VLBW) infants (NCT05228535).

Methods
VLBW infants were randomized to receive bovine milk-derived HMF with first feedings or delayed fortification at 80 ml/kg/day. Anthropometrics were assessed weekly through 36 weeks postmenstrual age (PMA). Unadjusted and adjusted (race, gender, gestational age, and birth weight) differences between study arms were examined using two-sample t-test and ANCOVA, respectively.

Results
Fifty-two VLBW infants (57% female, 60% Black) were enrolled. Baseline demographics did not differ between groups. Weight velocity at DOL 28 did not differ between study arms. Secondary outcomes including NPO occurrence, incidence of metabolic acidosis, NEC, retinopathy, or late-onset sepsis did not differ between groups.

Conclusion
Immediate fortification of enteral feedings with a bovine milk-derived HMF appears safe and well-tolerated although no clear growth benefit could be established.
Miconazole and phenothiazine hinder the quorum sensing regulated virulence in Pseudomonas aeruginosa
Authors: Gad Amany I. , El-Ganiny Amira M. , Eissa Ahmed G. , Noureldin Nada A. , Nazeih Shaimaa I. 
Published: May 2024

AbstractAntibiotic resistance is a major health problem worldwide. Pseudomonas aeruginosa is a Gram-negative pathogen with an arsenal of virulence factors and elevated antimicrobial resistance. It is a leading cause of nosocomial infections with high morbidity and mortality. The significant time and effort required to develop new antibiotics can be circumvented using alternative therapeutic strategies, including anti-virulence targets. This study aimed to investigate the anti-virulence activity of the FDA-approved drugs miconazole and phenothiazine against P. aeruginosa. The phenotypic effect of sub-inhibitory concentrations of miconazole and phenothiazine on biofilm, pyocyanin, protease, rhamnolipid and hemolysin activities in PAO1 strain was examined. qRT-PCR was used to assess the effect of drugs on quorum-sensing genes that regulate virulence. Further, the anti-virulence potential of miconazole and phenothiazine was evaluated in silico and in vivo. Miconazole showed significant inhibition of Pseudomonas virulence by reducing biofilm-formation approximately 45–48%, hemolytic-activity by 59%, pyocyanin-production by 47–49%, rhamnolipid-activity by approximately 42–47% and protease activity by 36–40%. While, phenothiazine showed lower anti-virulence activity, it inhibited biofilm (31–35%), pyocyanin (37–39%), protease (32–40%), rhamnolipid (35–40%) and hemolytic activity (47–56%). Similarly, there was significantly reduced expression of RhlR, PqsR, LasI and LasR following treatment with miconazole, but less so with phenothiazine. In-silico analysis revealed that miconazole had higher binding affinity than phenothiazine to LasR, RhlR, and PqsR QS-proteins. Furthermore, there was 100% survival in mice injected with PAO1 treated with miconazole. In conclusion, miconazole and phenothiazine are promising anti-virulence agents for P. aeruginosa.
Network-based elucidation of colon cancer drug resistance mechanisms by phosphoproteomic time-series analysis
Authors: Rosenberger George , Li Wenxue , Turunen Mikko , He Jing , Subramaniam Prem S. , Pampou Sergey , Griffin Aaron T. , Karan Charles , Kerwin Patrick , Murray Diana , Honig Barry , Liu Yansheng , Califano Andrea 
Published: May 2024

AbstractAberrant signaling pathway activity is a hallmark of tumorigenesis and progression, which has guided targeted inhibitor design for over 30 years. Yet, adaptive resistance mechanisms, induced by rapid, context-specific signaling network rewiring, continue to challenge therapeutic efficacy. Leveraging progress in proteomic technologies and network-based methodologies, we introduce Virtual Enrichment-based Signaling Protein-activity Analysis (VESPA)—an algorithm designed to elucidate mechanisms of cell response and adaptation to drug perturbations—and use it to analyze 7-point phosphoproteomic time series from colorectal cancer cells treated with clinically-relevant inhibitors and control media. Interrogating tumor-specific enzyme/substrate interactions accurately infers kinase and phosphatase activity, based on their substrate phosphorylation state, effectively accounting for signal crosstalk and sparse phosphoproteome coverage. The analysis elucidates time-dependent signaling pathway response to each drug perturbation and, more importantly, cell adaptive response and rewiring, experimentally confirmed by CRISPR knock-out assays, suggesting broad applicability to cancer and other diseases.
A locally solvent-tethered polymer electrolyte for long-life lithium metal batteries
Authors: Zhu Yanfei , Lao Zhoujie , Zhang Mengtian , Hou Tingzheng , Xiao Xiao , Piao Zhihong , Lu Gongxun , Han Zhiyuan , Gao Runhua , Nie Lu , Wu Xinru , Song Yanze , Ji Chaoyuan , Wang Jian , Zhou Guangmin 
Published: May 2024

AbstractSolid polymer electrolytes exhibit enhanced Li+ conductivity when plasticized with highly dielectric solvents such as N,N-dimethylformamide (DMF). However, the application of DMF-containing electrolytes in solid-state batteries is hindered by poor cycle life caused by continuous DMF degradation at the anode surface and the resulting unstable solid-electrolyte interphase. Here we report a composite polymer electrolyte with a rationally designed Hofmann-DMF coordination complex to address this issue. DMF is engineered on Hofmann frameworks as tethered ligands to construct a locally DMF-rich interface which promotes Li+ conduction through a ligand-assisted transport mechanism. A high ionic conductivity of 6.5 × 10−4 S cm−1 is achieved at room temperature. We demonstrate that the composite electrolyte effectively reduces the free shuttling and subsequent decomposition of DMF. The locally solvent-tethered electrolyte cycles stably for over 6000 h at 0.1 mA cm−2 in Li | |Li symmetric cell. When paired with sulfurized polyacrylonitrile cathodes, the full cell exhibits a prolonged cycle life of 1000 cycles at 1 C. This work will facilitate the development of practical polymer-based electrolytes with high ionic conductivity and long cycle life.
Frequency comb generation via synchronous pumped χ(3) resonator on thin-film lithium niobate
Authors: Cheng Rebecca , Yu Mengjie , Shams-Ansari Amirhassan , Hu Yaowen , Reimer Christian , Zhang Mian , Lončar Marko 
Published: May 2024

AbstractResonator-based optical frequency comb generation is an enabling technology for a myriad of applications ranging from communications to precision spectroscopy. These frequency combs can be generated in nonlinear resonators driven using either continuous-wave (CW) light, which requires alignment of the pump frequency with the cavity resonance, or pulsed light, which also mandates that the pulse repetition rate and cavity free spectral range (FSR) are carefully matched. Advancements in nanophotonics have ignited interest in chip-scale optical frequency combs. However, realizing pulse-driven on-chip Kerr combs remains challenging, as microresonator cavities have limited tuning range in their FSR and resonance frequency. Here, we take steps to overcome this limitation and demonstrate broadband frequency comb generation using a χ(3) resonator synchronously pumped by a tunable femtosecond pulse generator with on-chip amplitude and phase modulators. Notably, employing pulsed pumping overcomes limitations in Kerr comb generation typically seen in crystalline resonators from stimulated Raman scattering.
circCDK13-loaded small extracellular vesicles accelerate healing in preclinical diabetic wound models
Authors: Huang Qilin , Chu Ziqiang , Wang Zihao , Li Qiankun , Meng Sheng , Lu Yao , Ma Kui , Cui Shengnan , Hu Wenzhi , Zhang Wenhua , Wei Qian , Qu Yanlin , Li Haihong , Fu Xiaobing , Zhang Cuiping 
Published: May 2024

AbstractChronic wounds are a major complication in patients with diabetes. Here, we identify a therapeutic circRNA and load it into small extracellular vesicles (sEVs) to treat diabetic wounds in preclinical models. We show that circCDK13 can stimulate the proliferation and migration of human dermal fibroblasts and human epidermal keratinocytes by interacting with insulin-like growth factor 2 mRNA binding protein 3 in an N6-Methyladenosine-dependent manner to enhance CD44 and c-MYC expression. We engineered sEVs that overexpress circCDK13 and show that local subcutaneous injection into male db/db diabetic mouse wounds and wounds of streptozotocin-induced type I male diabetic rats could accelerate wound healing and skin appendage regeneration. Our study demonstrates that the delivery of circCDK13 in sEVs may present an option for diabetic wound treatment.