bluuebunny/crossref_metadata_2025_split huggingface dataset:
Promoting effective regionalization among Thai technical universities
Authors: Kirtikara Krissanapong 
Published: December 2011

PurposeThe purpose of this paper is to provide a background on the Thai higher education system which consists of over 160 public and private universities and colleges, under the purview of the Commission on Higher Education of the Ministry of Education. Particular emphasis is placed on the Rajmangala University of Technology (RMUT) system, consisting of nine regional technology universities, consolidated less than ten years ago from over 30 region‐based technology institutes, spreading over 20 provinces.Design/methodology/approachThe paper looks at challenges faced by the Commission and the University: aligning uneven and highly differentiated capacity with emergent and shifting educational needs; distributing or gaining access to resources to assure that quality is both established and maintained; and dealing with the existential fact that the very technological needs that one is seeking to educate for are changing literally moment by moment. Mechanisms on collaboration among the nine universities, and management practices to ensure effective regionalization are presented.FindingsThailand is witnessing a rapid expansion of the Thai higher education system. Two new university systems, the Rajbhat University system and the Rajmangala University of Technology‐RMUT system are newcomers. Both have evolved out of colleges under the original Ministry of Education for many decades. They have been under‐funded and inherited characteristics uncommon to universities. The RMUTs have to establish themselves among existing, mature and well developed technological universities. Issues and challenges are to be addressed by the new governance and management mechanisms.Originality/valueThis paper provides insight into the challenges and developments faced by the higher education system in Thailand.
Regionalization and harmonization of higher education in Asia
Authors: Hawkins John N. 
Published: December 2011

PurposeThe purpose of this paper is to see if economic regionalization in Asia is a trend for the future, and if it heralds educational regionalization, thus uniting economic internationalization and education.Design/methodology/approachThis has been shown to be the case in the European Union where it is still a work in progress and may well be sliding backward, and it is certainly the case in Asia where despite or perhaps because of the plethora of regional organizations (well over 100), policies and programs, to say nothing of the continuing historical tensions between nations and sub‐regions, the process of harmonization has lurched along and questions remain as to its long‐term substance.FindingsIt is suggested that the proposition of these goals is much easier than the implementation for a variety of political, economic, and cultural reasons.Originality/valueIn this study a conceptual framework utilizing the concepts of centripetal and centrifugal forces is introduced to facilitate a focus on the forces and factors affecting regionalization and harmonization of higher education in the Asian region.
Gleason grading: past, present and future
Authors: Delahunt Brett , Miller Rose J , Srigley John R , Evans Andrew J , Samaratunga Hemamali 
Published: December 2011

Delahunt B, Miller R J, Srigley J R, Evans A J & Samaratunga H  (2012) Histopathology60, 75–86  Gleason grading: past, present and futureIn 1966 Donald Gleason developed his grading and scoring system for prostatic adenocarcinoma. This classification was refined in 1974 and gained almost universal acceptance, being classified as a category 1 prognostic parameter by the College of American Pathologists. Modifications to the classification were recommended at a conference convened by the International Society of Urological Pathology (ISUP) in 2005. This modified classification has resulted in a significant upgrading of tumours, although some studies have shown a greater concordance between needle biopsy and radical prostatectomy scores when compared to classical Gleason (CG) grading. The ISUP consensus conference recommended that for needle biopsies higher tertiary patterns should be incorporated into the final Gleason score, and this has been correlated with biochemical failure, tumour volume and mortality. Recently the validity of including cribriform glands as a component of Gleason pattern 3 has been questioned and it has been recommended that all tumours showing cribriform architecture should be classified as Gleason pattern 4. The recommendations arising from the 2005 Consensus Conference were largely unsupported by validating data, yet this new grading system has achieved widespread usage. It is unfortunate that recent suggestions for further modification are similarly lacking in supporting evidence. In view of this it is recommended that the Modified Gleason Scoring Classification should continue to be utilized in its original (2005) format and that any future alterations should be implemented only when mandated by tumour‐related outcome studies.
Anatomy of the prostate revisited: implications for prostate biopsy and zonal origins of prostate cancer
Authors: Fine Samson W , Reuter Victor E 
Published: December 2011

Fine S W & Reuter V E  (2012) Histopathology 60, 142–152Anatomy of the prostate revisited: implications for prostate biopsy and zonal origins of prostate cancerOver the past 25 years, our understanding of prostatic disease has evolved secondary to the increased detection, treatment and study of both benign and neoplastic prostatic lesions. The advent of aggressive prostate‐specific antigen screening and standardization of extended transrectal needle biopsy protocols has resulted in significant stage migration and earlier detection of prostate cancers, a growing proportion of which are lower‐volume posterior peripheral zone tumours. Consequently, an increased incidence of anterior‐predominant prostate cancers has been observed. Given the histomorphological complexity of the prostate, these developments have necessitated a reconsideration of prostatic anatomy, biopsy strategies in the detection of anterior tumours and the determination and relevance of zonal origin in prostate cancer. This review will provide a contemporary update of these topics, while highlighting specific areas in which a keen understanding of prostatic histoanatomy may influence biopsy interpretation.
Prostate cancer and inflammation: the evidence
Authors: Sfanos Karen S , De Marzo Angelo M 
Published: December 2011

Sfanos K S & De Marzo A M  (2012) Histopathology 60, 199–215  Prostate cancer and inflammation: the evidenceChronic inflammation is now known to contribute to several forms of human cancer, with an estimated 20% of adult cancers attributable to chronic inflammatory conditions caused by infectious agents, chronic non‐infectious inflammatory diseases and/or other environmental factors. Indeed, chronic inflammation is now regarded as an ‘enabling characteristic’ of human cancer. The aim of this review is to summarize the current literature on the evidence for a role for chronic inflammation in prostate cancer aetiology, with a specific focus on recent advances regarding the following: (i) potential stimuli for prostatic inflammation; (ii) prostate cancer immunobiology; (iii) inflammatory pathways and cytokines in prostate cancer risk and development; (iv) proliferative inflammatory atrophy (PIA) as a risk factor lesion to prostate cancer development; and (v) the role of nutritional or other anti‐inflammatory compounds in reducing prostate cancer risk.
Molecular genetics of prostate cancer: emerging appreciation of genetic complexity
Authors: Barbieri Christopher E , Demichelis Francesca , Rubin Mark A 
Published: December 2011

Barbieri C E, Demichelis F & Rubin M A  (2012) Histopathology 60, 187–198  Molecular genetics of prostate cancer: emerging appreciation of genetic complexityThe emergence of Next Generation Sequencing is providing novel insights into cancer genomes as part of large‐scale efforts by the International Cancer Genome Consortium (ICGC), as well as individual Genome Centers. Studies performing whole genome or whole exome DNA sequencing are remarkable both for the alterations discovered and equally important for the infrequent nature of recurrent mutations. Current understanding of the prostate cancer (PCa) genome is based on extensive RNA‐sequencing for novel gene fusions and the first whole genome sequencing effort. The emerging data suggest that there are few recurrent genetic mutations. Surprisingly, the PCa genome undergoes frequent large‐scale genomic rearrangements that could not have been predicted using previous DNA sequencing approaches, or even whole exome sequencing approaches. These large‐scale rearrangements appear not to occur randomly, but demonstrate patterns leading to the ‘chained’ juxtaposition of known oncogenes. Future efforts in DNA sequencing will help to determine the recurrent nature of these genomic rearrangements, their association with other alterations and their effect on PCa disease progression. These discoveries raise the possibility that PCa might soon transition from a poorly understood, clinically heterogeneous disease to a collection of homogeneous subtypes identifiable by molecular criteria, and perhaps vulnerable to targeted therapies.
Prevalence of the CTNNB1 mutation genotype in surgically resected fibromatosis of the breast
Authors: Kim Taeeun , Jung Eun Ah , Song Ji Young , Roh Ji Hyeon , Choi Jong Sun , Kwon Jee Eun , Kang So Young , Cho Eun Yoon , Shin Jung Hee , Nam Suk‐Jin , Yang Jung Hyun , Choi Yoon‐La 
Published: December 2011

Kim T, Jung E A, Song J Y, Roh J H, Choi J S, Kwon J E, Kang S Y, Cho E Y, Shin J H, Nam S‐J, Yang J H & Choi Y‐L  (2012) Histopathology 60, 347–356  Prevalence of the CTNNB1 mutation genotype in surgically resected fibromatosis of the breastAims:  To investigate CTNNB1 mutation and β‐catenin expression in resected breast fibromatosis and to identify potential molecular markers of fibromatosis of the breast.Methods and results:  We selected 12 patients with fibromatosis of the breast who underwent surgical resection and were confirmed by histological examination. Ultrasonography findings for 10 patients were reviewed and only two cases were suspicious for fibromatosis on imaging. On core needle biopsy for pre‐operative diagnoses, only three cases were histologically suspicious for fibromatosis. Mutations in exon 3 of CTNNB1 were detected by direct DNA sequencing in nine (75.0%) cases: all were c.121G>A (p.T41A), which was much more frequent in breast fibromatoses than in other soft tissue lesions. Nuclear β‐catenin expression was observed in all cases and the level of expression was higher in cases with mutation. In eight of nine cases, the matched biopsy specimen showed the same CTNNB1 mutation status as the pre‐operative specimen.Conclusions:  In the majority of cases, clinical presentation and breast imaging are highly suspicious for carcinoma. Definitive pre‐operative pathological diagnosis by core needle biopsy is difficult. CTNNB1 mutation and nuclear β‐catenin expression are frequently detected in sporadic breast fibromatoses, suggesting their potential as a useful tool to distinguish breast fibromatoses from other neoplasms.
Expression of deleted in malignant brain tumours 1 (DMBT1) relates to the proliferation and malignant transformation of hepatic progenitor cells in hepatitis B virus‐related liver diseases
Authors: Deng Huan , Gao Ya‐Bo , Wang Hua‐Feng , Jin Xiao‐Long , Xiao Jia‐Cheng 
Published: December 2011

Deng H, Gao Y‐B, Wang H‐F, Jin X‐L & Xiao J‐C  (2012) Histopathology 60, 249–260  Expression of deleted in malignant brain tumours 1 (DMBT1) relates to the proliferation and malignant transformation of hepatic progenitor cells in hepatitis B virus‐related liver diseasesAims:  The molecular mechanisms underlying proliferation and malignant transformation of hepatic progenitor cells (HPCs) remain largely unknown. The purpose of this study was to evaluate the correlation between the expression of deleted in malignant brain tumours 1 (DMBT1) and the biological behaviour of HPCs in different hepatitis B virus (HBV)‐related human liver diseases.Methods and results:  Expression of DMBT1 in HPCs was investigated by double immunofluorescence labelling in control‐group and HBV‐related liver diseases, including hepatitis, hepatocellular carcinoma (HCC), non‐tumoral liver tissue away from HCC, non‐tumoral cirrhotic tissue adjacent to HCC, and non‐HCC cirrhosis. DMBT1‐positive HPCs were isolated by laser capture microdissection and subjected to duplex polymerase chain reaction in order to detect homozygous deletion of DMBT1. The number of DMBT1‐positive HPCs increased in direct proportion to inflammation severity. Loss of heterozygosity for DMBT1 was more frequent in HCC tumour area and non‐tumoral cirrhotic tissue adjacent to HCC, compared with other HBV‐related liver diseases (P < 0.05).Conclusions:  DMBT1 may play an important role in the proliferation of HPCs in HBV‐related liver diseases. Moreover, down‐expression of DMBT1 might enhance the risk of malignant transformation of HPCs.
Recognition of nonkeratinizing morphology in oropharyngeal squamous cell carcinoma – a prospective cohort and interobserver variability study*
Authors: Lewis Jr James S , Khan Raja A , Masand Ramya P , Chernock Rebecca D , Zhang Qin , Al‐Naief Nasser Said , Muller Susan , McHugh Jonathan B , Prasad Manju L , Brandwein‐Gensler Margaret , Perez‐Ordonez Bayardo , El‐Mofty Samir K 
Published: December 2011

Lewis J S Jr, Khan R A, Masand R P, Chernock R D, Zhang Q, Al‐Naief N S, Muller S, McHugh J B, Prasad M L, Brandwein‐Gensler M, Perez‐Ordonez B & El‐Mofty S K  (2012) Histopathology 60, 427–436 Recognition of nonkeratinizing morphology in oropharyngeal squamous cell carcinoma – a prospective cohort and interobserver variability studyAims:  Nonkeratinizing morphology in oropharyngeal squamous cell carcinoma (NKSCC) strongly correlates with human papillomavirus and p16 status, but as a unique diagnostic entity is not widely recognized by pathologists. We sought to prospectively examine the performance of a new histological typing system during 1 year of routine clinical practice (Aim 1) and also its reproducibility amongst six head and neck pathologists using a 40 case test set (Aim 2).Methods and Results:  The three histological types were: Type 1 (keratinizing), Type 2 (nonkeratinizing with maturation) and Type 3 (nonkeratinizing). For Aim 1, there were 85 cases. p16 immunohistochemistry was positive in five of the 18 (27.8%) cases classified as Type 1, 18 of the 19 (94.7%) as Type 2, and 47 of the 48 (97.9%) as Type 3. For Aim 2, agreement among pathologists on the test cases was best for types 1 and 3 (kappa values 0.62 and 0.56; P < 0.0001) and lowest for type 2 (kappa 0.35; P < 0.0001). All 21 cases classified as NK SCC (type 3) by any of the reviewers was p16 positive.Conclusions:  Pathologists can recognize NK SCC with good agreement, and when a pathologist classifies a tumour as NK SCC, this reliably predicts p16 positivity.
Ambulatory blood pressure monitoring in solid organ transplantation
Authors: Ramesh Prasad G. V. 
Published: December 2011

Ramesh Prasad GV. Ambulatory blood pressure monitoring in solid organ transplantation.  Clin Transplant 2011 DOI: 10.1111/j.1399‐0012.2011.01569.x.  © 2011 John Wiley & Sons A/S.Abstract:  Solid organ transplant recipients are at an increased risk for hypertension and cardiovascular disease. To assist in their management, 24‐h ambulatory blood pressure monitoring (ABPM) has become increasingly used in both clinical research settings and practice. ABPM has been used to better define post‐transplant hypertension incidence and prevalence in different solid organ transplantation populations. ABPM provides additional information on cardiovascular risk beyond that obtained by clinic‐based readings, based on its ability to assess 24‐h blood pressure (BP) load, detect nocturnal non‐dipping, and predict target organ damage. It has provided some assurance about the safety of living kidney donation. Information from ABPM can be used to guide living kidney donor selection, and because ABPM‐related data has been correlated with clinically important kidney and heart transplant recipient outcomes, it may be a valuable adjunct in their management. Despite these advantages, barriers to wider use of ABPM include expense, clinical inertia in hypertension management, lack of prospective clinical trial data, and clinical problems that compete with hypertension for attention such as acute or chronic allograft dysfunction. The increasing amount of research and clinical use for ABPM may allow for closer assessment and intervention to help address the increased cardiovascular risk faced by many solid organ transplant recipients.
Effect of Soil‐applied Zinc and Manganese on the Development of Rhizoctonia Aerial Blight of Soybean
Authors: Silva Ivanete Tonole , Rodrigues Fabrício Á vila , Baroni Júlio Cezar Parpaiola 
Published: December 2011

AbstractThis study aimed to investigate the effect of soil‐applied zinc (Zn) and manganese (Mn) rates on the development of aerial blight, caused by Rhizoctonia solani Kühn, in soybean. Plants (cv. ‘Conquista’) were grown in a typical Acrustox red‐yellow latosol amended with Zn rates (applied as ZnSO4·7H2O; 24% Zn) of 0, 1, 2, 4, 8 and 16 mg/dm3 of soil and Mn rates (applied as MnSO4·H2O; 36% Mn) of 0, 1.5, 3 and 6 mg/dm3 of soil and inoculated with R. solani. The relationship between Zn and Mn concentrations on leaf tissues and the rates of these micronutrients was linear. The incubation period was not affected by Zn and Mn rates. The relationship between application rates and the area under aerial blight progress curve was best described with a positive linear regression model for Zn and with a positive quadratic regression model for Mn. Results from this study showed that high foliar concentrations of Zn and Mn do not increase soybean resistance to aerial blight.
Fusobacterium nucleatum GroEL induces risk factors of atherosclerosis in human microvascular endothelial cells and ApoE−/− mice
Authors: Lee H‐R. , Jun H‐K. , Kim H‐D. , Lee S‐H. , Choi B‐K. 
Published: December 2011

SummaryInfection and inflammation are risk factors in the initiation and progression of atherosclerosis. Periodontitis is one of the most prevalent chronic inflammations of the oral cavity, and has been reported to be associated with systemic disease. In this study, we evaluated whether the heat‐shock protein GroEL of Fusobacterium nucleatum, one of the most prevalent bacteria in periodontitis, induces factors that predispose to atherosclerosis in human microvascular endothelial cells (HMEC‐1) and apolipoprotein E‐deficient (ApoE−/−) mice. GroEL induced the expression of chemokines such as monocyte chemoattractant protein‐1 and interleukin‐8 as well as cell adhesion molecules, such as intercellular adhesion molecule 1, vascular cell adhesion molecule 1, and E‐selectin. GroEL induced the activity of tissue factor and reduced the activity of the tissue factor pathway inhibitor. Foam cell formation was induced by GroEL. GroEL‐injected ApoE−/− mice showed significant atherosclerotic lesion progression compared with control mice. Serum levels of risk factors for atherosclerosis such as interleukin‐6, C‐reactive protein, and low‐density lipoprotein were increased in GroEL‐injected ApoE−/− mice compared with control mice, whereas serum levels of high‐density lipoprotein were decreased. We could detect significantly higher levels of anti‐F. nucleatum GroEL antibody in serum and F. nucleatum DNA in gingival crevicular fluid from patients with periodontitis than in that from healthy subjects. Our results indicate that the host response to the GroEL of periodontal pathogens like F. nucleatum may be a mechanism involved in atherosclerosis, supporting the association of periodontitis and systemic infection.
Nader Versus ETS: Who Should We Believe?
Authors: Robinson Sharon E. 
Published: December 2011

Nairn, A., & Associates. The Reign of ETS. Today's Education, 1980, 69, 58G–64G.Kaplan, R.M. Nader's Raid on the Testing Industry: Is it in the Best Interest of the Consumer? American Psychologist, 1982, 37, 15–23.
An integrated in vitro and in situ study of kinetics of myosin II from frog skeletal muscle
Authors: Elangovan R. , Capitanio M. , Melli L. , Pavone F. S. , Lombardi V. , Piazzesi G. 
Published: December 2011

Key points
Force and shortening in muscle are due to the ATP‐powered motor protein myosin II, polymerized in two bipolar arrays of motors that pull the two overlapping actin filaments toward the centre of the sarcomere.
The parameters of the myosin motor in situ have been best characterized for the skeletal muscle of the frog, from which single intact cells can be isolated allowing fast sarcomere level mechanics to be applied.
Up to now no reliable methods have been developed for the study of frog myosin with single molecule techniques.
In this work a new protocol for extraction and conservation of frog muscle myosin allows us to estimate the sliding velocity of actin on myosin (VF) and its modulation by pH, myosin density, temperature and substrate concentration.
By integrating in vitro and in situ parameters of frog muscle myosin we can relate kinetic and mechanical steps of the acto‐myosin ATPase.
Chlamydia trachomatisre-infections in a population-based cohort of women
Authors: Liu Bette , Guy Rebecca , Donovan Basil , Kaldor John M 
Published: December 2011

ObjectivesRe-infection with chlamydia may increase subsequent reproductive morbidity in women. The authors sought to identify characteristics associated with re-infection.MethodsA cohort of all women aged 10–49 years with a notification of genital chlamydia in the Australian state of New South Wales during 1999–2008 was defined. Probabilistic linkage was used to identify women with repeat notifications in the same period. The risk of repeat notification was examined according to age and other characteristics using proportional hazards regression.ResultsAmong 40 936 women in the cohort, 3236 had at least one repeat chlamydia notification over an average of 3.5 years of follow-up. The incidence of repeat notification was greatest in the first year after index notification (4.5 per 100 person-years) and decreased thereafter. The RR of repeat notification increased by 8% (95% CI 7% to 9%) for each year decrease in age. Compared with women aged 20–21 years at index chlamydia notification, women aged <16 years were twice as likely to have a repeat notification (adjusted HR 2.12, 95% CI 1.75 to 2.56), while women aged 26–27 years were half as likely (adjusted HR 0.53, 95% CI 0.43 to 0.66). Year of index notification, parity and concurrent or past gonorrhoeal infection were also significantly associated with the risk of repeat notification, but socioeconomic status and area of residence were not.ConclusionsYounger age is a strong predictor of chlamydia re-infection in women. The results support targeting interventions to prevent re-infections to very young women.