bluuebunny/crossref_metadata_2025_split huggingface dataset:
A review of g‐C3N4‐based photocatalytic materials for photocatalytic CO2 reduction
Authors: Tang Jing , Guo Chuanyu , Wang Tingting , Cheng Xiaoli , Huo Lihua , Zhang Xianfa , Huang Chaobo , Major Zoltán , Xu Yingming 
Published: May 2024

AbstractCurrently, the concentration of carbon dioxide (CO2) has exceeded 400 ppm in the atmosphere. Thus, there is an urgent need to explore CO2 reduction and utilization technologies. Photocatalytic technology can convert CO2 to valuable hydrocarbons (CH4, CH3OH, and C2H5OH, etc.), realizing the conversion of solar energy to chemical energy as well as solving the problems of fossil fuel shortage and global warming. Graphitic carbon nitride (g‐C3N4), as a two‐dimensional nonmetallic semiconductor material, shows great potential in the field of CO2 photoreduction due to its moderate bandgap, easy synthesis method, low cost, and visible light response properties. This review elaborates the research progress of g‐C3N4‐based photocatalysts for photocatalytic CO2 reduction. The modification strategies (e.g., morphology engineering, elemental doping, crystallinity modulation, cocatalyst modification, and constructing heterojunction) of g‐C3N4‐based photocatalysts for CO2 reduction application have been discussed in detail. Finally, the challenges and development prospects of g‐C3N4‐based photocatalytic materials for CO2 reduction are presented.
Performance gap and the timing of corporate social responsibility disclosure‐A trust repair perspective
Authors: Tu Qiuyang , Duan Zhao , Zhou Hong 
Published: May 2024

AbstractBased on the theory of firm behavior, we explain the voluntary corporate social responsibility (CSR) disclosure behavior of firms from the perspective of trust repair and regard the process of firms' response to the CSR institution as an important way to trust repair for firms' management. We adopt an event history approach with a sample of Chinese firms listed on the A‐share market from 2008 to 2020 and find that faster engagement in CSR disclosure is one of the important trust repair methods for management when firms face performance gaps, and performance gaps positively incentivize firms to voluntarily engage in CSR disclosure. In addition, managers consider the total costs, risks, and benefits of different trust repair methods, there is a substitution effect between different trust repair methods, and the disclosure of internal audit reports and philanthropic donations negatively moderates the relationship between performance gap and CSR disclosure. Our study has important implications for understanding how firm performance affects CSR strategic decisions.
Comparison of three machine learning algorithms for classification of B‐cell neoplasms using clinical flow cytometry data
Authors: Dinalankara Wikum , Ng David P. , Marchionni Luigi , Simonson Paul D. 
Published: May 2024

AbstractMultiparameter flow cytometry data is visually inspected by expert personnel as part of standard clinical disease diagnosis practice. This is a demanding and costly process, and recent research has demonstrated that it is possible to utilize artificial intelligence (AI) algorithms to assist in the interpretive process. Here we report our examination of three previously published machine learning methods for classification of flow cytometry data and apply these to a B‐cell neoplasm dataset to obtain predicted disease subtypes. Each of the examined methods classifies samples according to specific disease categories using ungated flow cytometry data. We compare and contrast the three algorithms with respect to their architectures, and we report the multiclass classification accuracies and relative required computation times. Despite different architectures, two of the methods, flowCat and EnsembleCNN, had similarly good accuracies with relatively fast computational times. We note a speed advantage for EnsembleCNN, particularly in the case of addition of training data and retraining of the classifier.
Developmental stage‐dependent effects of perceived predation risk on nestling tree swallows (Tachycineta bicolor)
Authors: McNew Sabrina M. , Taff Conor C. , Zimmer Cedric , Uehling Jennifer J. , Ryan Thomas A. , Chang van Oordt David , Houtz Jennifer L. , Injaian Allison S. , Vitousek Maren N. 
Published: May 2024

AbstractThe risk of predation directly affects the physiology, behavior, and fitness of wild birds. Strong social connections with conspecifics could help individuals recover from a stressful experience such as a predation event; however, competitive interactions also have the potential to exacerbate stress. Few studies have investigated the interaction between environmental stressors and the social landscape in wild bird populations. In 2 years of field studies, we experimentally simulated predation attempts on breeding female tree swallows (Tachicyneta bicolor). At the same time, we manipulated female breast plumage color, a key social signal. Simulated predation events on tree swallows early in the nestling period reduced young nestlings' mass by approximately 20% and shortened telomere lengths. Ultimately, only 31% of nestlings in the predation group fledged compared with 70% of control nestlings. However, the effects of experimental manipulations were timing dependent: the following year when we swapped the order of the experimental manipulations and simulated predation during incubation, there were no significant effects of predation on nestling condition or fledging success. Contrary to our expectations, manipulation of the social environment did not affect the response of tree swallows to simulated predation. However, manipulating female plumage during the nestling period did reduce nestling skeletal size and mass, although the effects depended on original plumage brightness. Our data demonstrate that transient stressors on female birds can have carry‐over effects on their nestlings if they occur during critical periods in the breeding season.
Bridging personality dimensions and eating symptoms: A transdiagnostic network approach
Authors: Ruiz‐Gutiérrez Jose , Miras‐Aguilar María del Mar , Rodríguez‐Pérez Noelia , Ventura Ludovica , González Gómez Jana , del Barrio Andrés Gómez , Gónzalez‐Blanch Cesar 
Published: May 2024

AbstractObjectiveEating disorders (ED) have recently been studied from a network approach, conceptualising them as a complex system of interconnected variables, while highlighting the role of non‐ED symptoms and personality dimensions. This study aims to explore the connections between personality and ED symptoms, identify central nodes, and compare the EDs network to a healthy control network.MethodsWe employed network analysis to examine the personality‐ED symptom connections in 329 individuals with an ED diagnosis and 192 healthy controls. We estimated a regularised partial correlation network and the indices of centrality and bridge centrality to identify the most influential nodes for each group. Network differences between groups were also examined.ResultsLow Self‐Directedness and high Harm avoidance emerged as central bridge nodes, displaying the strongest relationship with ED symptoms. Both networks differed in their global connectivity and structure, although no differences were found in bridge centrality and centrality indices.ConclusionsThese findings shed light on the role of personality dimensions, such as Self‐Directedness and Harm Avoidance in the maintenance of ED psychopathology, supporting the transdiagnostic conceptualisation of ED. This study advances a deeper understanding of the complex interplay between personality dimensions and ED symptoms, offering potential directions for clinical interventions.
Synthesis, characterization, and implementation of BaNiO3 perovskite nanoparticles as thin film supercapacitor electrode
Authors: Janjua Abdul Niqash , Ahmed Aamir , Singh Anoop , Sundramoorthy Ashok K. , Young Sheng‐Joue , Chu Yen‐Lin , Arya Sandeep 
Published: May 2024

AbstractThis work is the first attempt to explore the supercapacitor applications of Barium nickelate (BaNiO3) perovskite nanoparticles. The nanoparticles are synthesized using a simple combustion method and their morphology, elemental composition, and so forth are studied using standard characterization methods such as x‐ray diffraction spectroscopy (XRD), field emission scanning electron microscopy (FESEM), and so forth. The nanoparticles were found to be hexagonal in shape, with an average particle size of 16 nm, and the elemental analysis confirms the successful synthesis of the BaNiO3 perovskite nanoparticles. For electrochemical studies, the electrodes are fabricated over a wearable and flexible conductive fabric (CF) substrate. A slurry paste of the synthesized BaNiO3 nanoparticles is applied over CF and dried overnight, thereby forming a thin film electrode. The fabricated electrode acts as a positive electrode with a high specific capacitance of 508.64 F g−1 at 2.2 A g−1 current density. Upon increasing the current density, the electrode maintains 60% of its specific capacitance and displays 97% cyclic stability over 5000 cycles. The electrochemical impedance spectroscopy (EIS) study indicates excellent conductivity of the electrode, with a bulk resistance of 3.2 Ohms. The electrochemical performance of the fabricated electrode is also compared with various previously reported works and the electrode displays higher specific capacitance and better cyclic stability. These findings suggest that the BaNiO3 perovskite nanoparticles‐based electrode holds promise for utilization as an anode material in supercapacitor applications.
Clinicopathologic and molecular correlates to neoadjuvant chemotherapy‐induced pathologic response in breast angiosarcoma
Authors: Chang Hsin‐Yi , Dermawan Josephine K. , Kuba Maria Gabriela , Crago Aimee M. , Singer Samuel , Tap William , Chi Ping , D'Angelo Sandra , Rosenbaum Evan , Antonescu Cristina R. 
Published: May 2024

AbstractBoth primary and secondary breast angiosarcoma (AS) are characterized by multifocal presentation and aggressive behavior. Despite multimodality therapy, local and distant relapse rates remain high. Therefore, neoadjuvant chemotherapy (NACT) is employed to improve the R0 resection rates and survival, but its benefits remain controversial. Herein, we investigate pathologic and molecular correlates to NACT‐induced histologic response in a group of 29 breast AS, 4 primary and 25 radiation‐associated (RA). The two NACT regimens applied were anthracycline‐ and non‐anthracycline‐based. The pathologic response grade was defined as: I: ≤ 50%, II: 51%–90%, III: 91%–99%, and IV: 100%. An additional 45 primary AS and 102 RA‐AS treated by surgery alone were included for survival comparison. The genomic landscape was analyzed in a subset of cases and compared to a cohort of AS without NACT on a paired tumor‐normal targeted DNA NGS platform. All patients were females, with a median age of 31 years in primary AS and 68 years in RA‐AS. All surgical margins were negative in NACT group. The NACT response was evenly divided between poor (Grades I–II; n = 15) and good responders (Grades III–IV; n = 14). Mitotic count >10/mm2 was the only factor inversely associated with pathologic response. By targeted NGS, all 10 post‐NACT RA‐AS demonstrated MYC amplification, while both primary AS harbored KDR mutations. TMB or other genomic alterations did not correlate with pathologic response. All four patients with Grade IV response remained free of disease. The good responders had a significantly better disease‐specific survival (p = 0.04). There was no survival difference with NACT status or the NACT regimens applied. However, NACT patients with MYC‐amplified tumors showed better disease‐free survival (p = 0.04) compared to MYC‐amplified patients without NACT. The overall survival of NACT group correlated with size >10 cm (p = 0.02), pathologic response (p = 0.04), and multifocality (p = 0.01) by univariate, while only size >10 cm (p = 0.03) remained significant by multivariate analysis.
The well‐worn route revisited: Striatal and hippocampal system contributions to familiar route navigation
Authors: Buckley Matthew , McGregor Anthony , Ihssen Niklas , Austen Joseph , Thurlbeck Simon , Smith Shamus P. , Heinecke Armin , Lew Adina R. 
Published: May 2024

AbstractClassic research has shown a division in the neuroanatomical structures that support flexible (e.g., short‐cutting) and habitual (e.g., familiar route following) navigational behavior, with hippocampal–caudate systems associated with the former and putamen systems with the latter. There is, however, disagreement about whether the neural structures involved in navigation process particular forms of spatial information, such as associations between constellations of cues forming a cognitive map, versus single landmark‐action associations, or alternatively, perform particular reinforcement learning algorithms that allow the use of different spatial strategies, so‐called model‐based (flexible) or model‐free (habitual) forms of learning. We sought to test these theories by asking participants (N = 24) to navigate within a virtual environment through a previously learned, 9‐junction route with distinctive landmarks at each junction while undergoing functional magnetic resonance imaging (fMRI). In a series of probe trials, we distinguished knowledge of individual landmark‐action associations along the route versus knowledge of the correct sequence of landmark‐action associations, either by having absent landmarks, or “out‐of‐sequence” landmarks. Under a map‐based perspective, sequence knowledge would not require hippocampal systems, because there are no constellations of cues available for cognitive map formation. Within a learning‐based model, however, responding based on knowledge of sequence would require hippocampal systems because prior context has to be utilized. We found that hippocampal–caudate systems were more active in probes requiring sequence knowledge, supporting the learning‐based model. However, we also found greater putamen activation in probes where navigation based purely on sequence memory could be planned, supporting models of putamen function that emphasize its role in action sequencing.
Fluorescent Membrane Probes Obey the Israelachvili Rules
Authors: Bayard Felix , Matile Stefan 
Published: May 2024

AbstractWhen developing fluorescent membrane probes, we naturally tend to focus on the fluorophore itself. In this study, we show that sometimes it can be beneficial to shift attention from the center to the periphery, to maximize multiple interfacing with complex changing environments. Palmitylation for hydrophobic interfacing and glutamate dendrons for hydrophilic interfacing are combined to improve the performance of fluorescent flipper probes. We show that to increase performance in membranes, solubility in water is important, and to increase solubility in water, we increase the hydrophobicity of the flipper probe. These seemingly paradoxical measures are taken to satisfy the Israelachvili rules. They state that only inverted cone amphiphiles form soluble micelles in water, while inverted micelles from cone shaped amphiphiles precipitate into hexagonal 1 supramolecular polymers, and the intermediate cylindrical amphiphiles show intermediate behavior dominated by bilayers and lamellar precipitates. The normal micelles obtained from inverted cone flipper amphiphiles prevent precipitation and prepare for efficient transfer into the lipid bilayer membranes. The results are flippers that break all records set by the 2016 original with regard to effective brightness, responsiveness to membrane order, anchoring in disordered membranes, partitioning into membranes of high order, and stable labeling of membranes of interest. The lessons learned confirm the obvious: The Israelachvili rules apply also to fluorescent membrane probes. They promise literally bright perspectives for fluorescent membrane probes.
“What concerns me or what is most interesting to me”: A qualitative study about what influences adolescent engagement with public health issues
Authors: Nguyen Binh , Raeside Rebecca , Kite James , Freeman Becky , Phongsavan Philayrath , Cheng Hoi Lun , Steinbeck Katharine , Baur Louise Alison , Partridge Stephanie Ruth 
Published: May 2024

AbstractIssues AddressedPromoting public health messages in adolescence may influence future health outcomes. A better understanding of what influences adolescent engagement with public health issues is needed.MethodsAdolescents aged 13–19 years from New South Wales, Australia, were recruited via study advertisements to participate in an online focus group. All provided informed consent and completed a short survey including demographics and selection of leading public health issues of concern. Participants attended a 75–90 min focus group conducted through Zoom teleconference that explored top public health issues of concern to participants, and barriers/enablers to engage with these issues. Qualitative data was thematically analysed using NVivo. A working group reached consensus on final themes.ResultsOut of 18 participants (mean 15.4 [SD: 2.2] years; 50% female), most attended high school (83%), spoke predominantly English at home (89%), and resided in metropolitan areas (94%). The top public health issues of concern selected were mental health (56%) and the environment/climate change (56%). From the thematic analysis, underlying drivers of adolescent engagement with public health issues included: personal connection to these issues, broader societal impact, and exposure to public health issues on digital media. Barriers included feeling unempowered, and a lack of support and opportunities.ConclusionsThis study provides insights on the barriers and enablers of adolescents engaging with public health issues of concern to them.So What?Understanding this may help health professionals and researchers to design more influential public health campaigns and interventions, including through co‐design processes, which may improve future health outcomes.
Tectorigenin inhibits inflammatory responses in murine inflammatory bowel disease and LPS‐stimulated macrophages via inactivating MAPK signaling pathway
Authors: Huang Hong , Tang Sanhui , Zhou Yanghong , Cai Yi 
Published: May 2024

AbstractBackgroundConsidering the antihepatitis effects of Tectorigenin (TEC), and the same adenosine mitogen‐activated protein kinase (MAPK) pathway in both hepatitis and inflammatory bowel disease (IBD) models, exploring the role of TEC in IBD is contributive to develop a new treatment strategy against IBD.MethodsThe IBD mouse model was constructed by feeding with dextran sodium sulfate (DSS) and injection of TEC. Afterward, the mouse body weight, colon length, and disease activity index (DAI) were tested to assess the enteritis level. Mouse intestine lesions were detected by hematoxylin and eosin staining. Murine macrophages underwent lipopolysaccharide (LPS) induction to establish an inflammation model. Cell viability was determined by cell counting kit‐8 assay. Enzyme‐linked immunosorbent assay was performed to measure interleukin 6 (IL‐6) and tumor necrosis factor‐α (TNF‐α) levels. Cyclooxygenase‐2 (COX‐2) and inducible nitric oxide synthase (iNOS) expressions were quantified via quantitative reverse transcription polymerase chain reaction. Levels of MAPK pathway‐related proteins (p‐P38, P38, p‐Jun N‐terminal kinase (JNK), JNK, signal‐regulated kinase (ERK), p‐ERK), COX‐2 and iNOS were quantitated by Western blot.ResultsTEC improved the inflammatory response through ameliorating weight loss, shortening colon, and increasing DAI score in IBD mouse. Expressions of intestinal inflammatory factors (IL‐6, TNF‐α, iNOS and COX‐2) and MAPK pathway‐related proteins (p‐P38, p‐JNK, and p‐ERK) were increased both in DSS‐induced mouse intestinal tissue, but TEC inhibited expressions of inflammatory factors. The same increased trend was identified in LPS‐induced macrophages, but TEC improved macrophage inflammation, as evidenced by downregulation of inflammatory factors.ConclusionTEC mitigates IBD and LPS‐induced macrophage inflammation in mice via inhibiting MAPK signaling pathway.
Stereotactic radiosurgery and radiotherapy for brainstem metastases: An international multicenter analysis
Authors: Ehret Felix , Rueß Daniel , Blanck Oliver , Fichte Susanne , Chatzikonstantinou Georgios , Wolff Robert , Mose Lucas , Mose Stephan , Fortmann Thomas , Lehrke Ralph , Turna Menekse , Caglar Hale Basak , Mortasawi Farshin , Bleif Martin , Krug David , Ruge Maximilian I. , Fürweger Christoph , Muacevic Alexander 
Published: May 2024

AbstractBrainstem metastases (BSM) present a significant neuro‐oncological challenge, resulting in profound neurological deficits and poor survival outcomes. Stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (FSRT) offer promising therapeutic avenues for BSM despite their precarious location. This international multicenter study investigates the efficacy and safety of SRS and FSRT in 136 patients with 144 BSM treated at nine institutions from 2005 to 2022. The median radiographic and clinical follow‐up periods were 6.8 and 9.4 months, respectively. Predominantly, patients with BSM were managed with SRS (69.4%). The median prescription dose and isodose line for SRS were 18 Gy and 65%, respectively, while for FSRT, the median prescription dose was 21 Gy with a median isodose line of 70%. The 12‐, 24‐, and 36‐month local control (LC) rates were 82.9%, 71.4%, and 61.2%, respectively. Corresponding overall survival rates at these time points were 61.1%, 34.7%, and 19.3%. In the multivariable Cox regression analysis for LC, only the minimum biologically effective dose was significantly associated with LC, favoring higher doses for improved control (in Gy, hazard ratio [HR]: 0.86, p < .01). Regarding overall survival, good performance status (Karnofsky performance status, ≥90%; HR: 0.43, p < .01) and prior whole brain radiotherapy (HR: 2.52, p < .01) emerged as associated factors. In 14 BSM (9.7%), treatment‐related adverse events were noted, with a total of five (3.4%) radiation necrosis. SRS and FSRT for BSM exhibit efficacy and safety, making them suitable treatment options for affected patients.
Decoding pharmacogenomic test interpretation and application to patient care
Authors: Donnelly Roseann S. , Cavallari Larisa H. , McCune Jeannine S. , Trofe‐Clark Jennifer , Formea Christine M. , Hoffecker Glenda , Csere Molly M. , Anderson Keri C. , Bhat Shubha , Mosley Scott A. , Ma Qing , Ferdock Ariel , Hoffman James M. , Hicks J. Kevin , Caudle Kelly E. 
Published: May 2024

AbstractPharmacogenomics is a growing area of medicine, and pharmacists across clinical practice settings have the opportunity to individualize medication selection and dosing using genetic data. However, many practicing pharmacists may feel ill‐equipped to interpret pharmacogenomic test results because of insufficient education and training. Evidence‐based, updated, and freely available resources such as the Clinical Pharmacogenetics Implementation Consortium guidelines can help pharmacists interpret and apply pharmacogenomic test results to patient care. Although gaps for the application of pharmacogenomic information exist, this commentary aims to demystify the interpretation of pharmacogenomic test results and empower pharmacists to apply genetic data alongside other clinical variables to optimize medication‐related outcomes for their patients. An “ABCD” framework is proposed to guide pharmacists through the steps: (1) Actionability—Are the gene(s) clinically relevant for the patient? (2) Be Mindful of Limitations—What are the caveats with pharmacogenomic test results and reports? (3) Clinical Practice Guidelines—How do you use pharmacogenomic test results to guide clinical decision‐making? and (4) Document and Discuss—How do you educate the patient about their pharmacogenomic test results and document the results for future use? Key concepts are illustrated using a psychiatric patient case example.