bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ontogeny of Drosophila melanogaster female sex‐appeal and cuticular hydrocarbons
Authors: ARIENTI Marisa , ANTONY Claude , WICKER‐THOMAS Claude , DELBECQUE Jean‐Paul , JALLON Jean‐Marc 
Published: September 2010

AbstractThe chemical communication system in Drosophila melanogaster Meigen, 1830 plays a major role in courtship and consists of the male‐specific cis‐Vaccenyl acetate and sex‐specific contact pheromones, cuticular hydrocarbons (CHC), which build up during ontogeny (first 4 days). They replace longer CHCs, common to both sexes and present only after the imaginal eclosion. A detailed quantitative description of the evolution of cuticular unsaturated hydrocarbons with age is presented here for males and females of different D. melanogaster strains, which have been bred in well controlled environments. Monoenes appear in both sexes at around 12 h, before female dienes. The present paper argues that this is likely linked to the switching on of a new set of genes. Ecdysone, which is more abundant in females than in males during this critical period, might control this switch. Parallel behavioral studies show that whereas female of all ages trigger early mature male courtship steps like wing vibration, only females older than 1 day trigger late courtship steps like attempted copulation. This supports the hypothesis that late male courtship steps might be triggered by the CHCs, which build up after this age, especially female‐specific (Z,Z)–7,11 – and (Z,Z)–5,9‐dienes
The Church of the Creator Part II: Later Developments and the Sacralization of Race in Multicultural America
Authors: Michael George 
Published: September 2010

AbstractAfter the death of Ben Klassen in 1993, the Church of the Creator languished for a few years, but in 1995, an enterprising young law student, Matthew Hale, revived the church and became the movement’s recognized leader. He rechristened the organization as the “World Church of the Creator” and in the months that followed, numerous Creativity branches united under Hale’s leadership. During the late 1990s and early 2000s, the World Church of the Creator was at the center of several free speech controversies that strained communities and divided legal scholars. The Creativity movement has always been a relatively modest operation, yet, it has had a significant influence on the broader racialist movement of which it is only a small part. Although, the church is currently in retreat, it is likely that its ideology will continue to inspire extremist activists in the future.
Sheikh Yūsuf al‐Qaradawi: A Moderate Voice from the Muslim World?
Authors: Soage Ana Belén 
Published: September 2010

AbstractDr Yusuf al‐Qaradawi is one of the most prominent and respected religious scholars in the Muslim world, particularly amongst so‐called moderate Islamists. In this article, we start by providing a summary of his biography, including the influence of the Muslim Brothers Society on his political and intellectual development. We will then explore his key ideas, notably the adoption of the term wasatiyya or ‘middle way’ to describe his position vis‐à‐vis the main questions facing both Muslims and Islam. Finally, we will take a look at his attitude towards those who not share his vision, which exemplifies the less appealing aspects of his thought.
Municipal shared service collaboration in the Alberta Capital Region: The case of recreation
Authors: LeSage Edward C. , McMillan Melville L. , Hepburn Neil 
Published: September 2010

Abstract: This article examines the determinants of participation of Edmonton‐area municipalities in shared services arrangements for recreational and cultural services. Potential determinants emerge from the literature on inter‐municipal collaborative arrangements, but this analysis extends the empirical work on the determinants of participation to encompass small municipalities and to consider the appeal of potential partners. The major finding is that, in the Edmonton environment (and likely in many others), municipal population size is the critical determinant of participation, and participation is inversely related to population size.Sommaire :
Le présent article examine les facteurs déterminants de la participation des municipalités de la région d'Edmonton dans les ententes relatives aux services partagés en ce qui concerne les services récréatifs et culturels. Les déterminants potentiels proviennent de la littérature sur les ententes de collaboration entre les municipalités. Cependant, l'analyse prolonge le travail empirique sur les facteurs déterminants de la participation pour y inclure les petites municipalités et pour tenir compte de l'appel à des partenaires potentiels. Le principal résultat est que, dans la région d'Edmonton (et vraisemblablement dans de nombreuses autres régions), la taille de la population municipale est le déterminant critique de la participation, et la participation est inversement proportionnelle à la taille de la population.
Association between metabolic syndrome and periodontal disease
Authors: Andriankaja OM , Sreenivasa S , Dunford R , DeNardin E 
Published: September 2010

AbstractBackground:  Metabolic syndrome has been suggested as a potential risk factor for periodontal disease. Data based on NHANES III, with 7431 subjects aged 20 years or older, were analysed to confirm the association between metabolic syndrome and periodontal disease, and identify which components of metabolic syndrome might play a role in this association.Methods:  Clinical criteria for metabolic syndrome included: (1) abdominal obesity; (2) increased triglycerides; (3) decreased HDL cholesterol; (4) hypertension or current use of hypertension medication; and (5) high fasting plasma glucose. Periodontal disease was evaluated by probing pocket depth (PPD) and was defined as mean PPD ≥2.5 mm.Results:  Women with two or more metabolic components had significantly increased odds of having periodontal disease as compared to those with no component [(two components, OR = 5.6 (95% CI: 2.2–14.4); three or more, OR = 4.7 (2.0–11.2)]. Using the definition of metabolic syndrome as having three to five metabolic components (reference group with <3 components), the adjusted odds ratios were 1.0 (0.7–1.6) for men and 2.1 (1.2–3.7) for women. Abdominal obesity was the largest contributory factor in both genders.Conclusions:  While the association between metabolic syndrome and periodontal disease was particularly significant for women, abdominal obesity appeared to be the contributing metabolic factor for both genders.
Effects of different topical agents on enamel demineralization around orthodontic brackets: an in vivo and in vitro study
Authors: Uysal T , Amasyali M , Koyuturk AE , Ozcan S 
Published: September 2010

AbstractBackground:  The aim of this study was to evaluate the in vivo and in vitro effects of a casein phosphopeptide‐amorphous calcium phosphate (CPP‐ACP) and fluoride containing topical agents in reducing enamel demineralization around orthodontic brackets, and to compare this with a control group.Methods:  Twenty‐one patients and 60 extracted premolars were divided into three groups: two experimental and one control. Tooth Mousse® (CPP‐ACP gel; GC‐Corp, Tokyo, Japan) and Fluoridin N5® (Fluoride gel; Voco‐GmbH, Cuxhaven, Germany) were applied to tooth surfaces around orthodontic brackets in the experimental groups. Teeth were extracted after 60 days to evaluate the in vivo effects of the testing materials. For the in vitro experiment, samples were cycled for 14 days through a daily procedure of demineralization. All teeth were sectioned and evaluated by superficial microhardness analysis. An indentation was made from two positions (occlusal‐cervical) and one depth (10 μm).Results:  Comparisons of occlusal and cervical microhardness scores for all specimens showed no statistically significant side differences. A multiple comparison test showed that the use of CPP‐ACP and fluoride containing topical gels were more significantly efficient than the control group (p <0.001). No significant differences were detected between CPP‐ACP and the fluoride groups against demineralization.Conclusions:  In vivo and in vitro evaluations indicated that CPP‐ACP and fluoride containing agents successfully inhibited caries around orthodontic brackets.
Gingival status, crevicular fluid tissue‐type plasminogen activator, plasminogen activator inhibitor‐2 levels in pregnancy versus post‐partum
Authors: Buduneli N , Becerik S , Buduneli E , Baylas H , Kinnby B 
Published: September 2010

AbstractBackground:  This study was conducted to evaluate a possible link between periodontal status of pregnant women and the plasminogen activator system in gingival crevicular fluid (GCF).Methods:  GCF samples were obtained from four interproximal sites of anterior teeth in 43 women during the second trimester and also after delivery. Full mouth dental plaque, bleeding on probing (BOP) and probing depth (PD) values were recorded at six sites/tooth in each subject. GCF levels of tissue type plasminogen activator (t‐PA) and its inhibitor, plasminogen activator‐inhibitor‐2 (PAI‐2) were determined by ELISA. Data comparisons between pregnancy and post‐partum were made by Wilcoxon signed rank test.Results:  The number of pockets with a PD >4 mm and total volume of GCF sampled were reduced significantly after delivery (p = 0.000 and p = 0.013, respectively). No significant differences were detected in GCF concentrations of t‐PA or PAI‐2 between pregnancy and post‐partum.Conclusions:  Our results suggest that GCF t‐PA and PAI‐2 concentrations are not affected by pregnancy. Reductions in PD values and GCF volume following delivery indicate a resolution of oedema in gingival tissues, possibly related to hormonal changes due to the ending of pregnancy.
A case-crossover study of occupational laceration injuries in pork processing: methods and preliminary findings
Authors: Lander Lina , Sorock Gary S , Stentz Terry L , Eisen Ellen A , Mittleman Murray , Hauser Russ , Perry Melissa J 
Published: September 2010

ObjectivesMeatpacking remains a hazardous and largely unexamined industry. Despite prevention efforts, laceration injuries, among others, remain high. We estimated the magnitude of associations between transient exposures such as equipment malfunction, performing an unusual work task, rushing, and occurrence of laceration injuries.MethodsInjured workers were recruited from two pork-processing plants, one in Iowa and one in Nebraska. A telephone interview was conducted within 7 days of the injury, on average to collect information on fixed and transient exposures preceding the injury event. Case-crossover methodology was used to evaluate case and control data within the same subject, thus controlling for between-subject confounding. A Mantel–Haenszel estimator for person-time data was used to estimate the relative risks of injury and transient exposures of interest.ResultsOf the 362 workers with lacerations between April 2006 and October 2007, 153 (42%) were interviewed (74% male, 41% Hispanic). Forty-eight per cent were injured by a knife or a knife-like object such as scissors or a band saw. Other sources of lacerations included sharp edges and hooks. Tool sharpening was associated with the highest RR of laceration (RR 8.4, 95% CI 5.4 to 12.8) followed by slipping (RR 74.8, 95% CI 30.5 to 183.3), equipment malfunction (RR 3.8, 95% CI 2.8 to 5.3), and performing an unusual task (RR 3.7, 95% CI 2.6 to 5.2). Being tired, distracted, or rushing were not significant risk factors for a laceration.ConclusionsAspects of the physical environment and work practices appear to be significant risk factors for laceration injury in meatpacking. Personal risk factors were less significant in this study.
Occupational exposure to organic solvents and lymphoid neoplasms in men: results of a French case-control study
Authors: Orsi Laurent , Monnereau Alain , Dananche Brigitte , Berthou Christian , Fenaux Pierre , Marit Gerald , Soubeyran Pierre , Huguet Françoise , Milpied Noel , Leporrier Michel , Hemon Denis , Troussard Xavier , Clavel Jacqueline 
Published: September 2010

ObjectivesInvestigating the role of occupational exposure to solvents in the occurrence of lymphoid neoplasms (LNs) in men.MethodsThe data were generated by a French hospital-based case-control study, conducted in six centres in 2000–2004. The cases were incident cases aged 18–75 years with a diagnosis of LN. During the same period, controls of the same age and gender as the cases were recruited in the same hospitals, mainly in the orthopaedic and rheumatological departments. Exposure to solvents was assessed using standardised occupational questionnaires and case-by-case expert assessment. Specific quantification of benzene exposure was attempted. The analyses included 491 male patients (244 cases of non-Hodgkin's lymphoma (NHL), 87 of Hodgkin's lymphoma, 104 of lymphoproliferative syndrome and 56 of multiple myeloma) and 456 male controls. Unconditional logistic regressions were used to estimate OR and 95% CI.ResultsSolvent exposure, all solvents considered together, was marginally associated with NHL (OR=1.4 (1.0 to 2.0) p=0.06), but not with other LNs. No association with the main chemical series of solvents was observed. There was no trend with the average intensity or frequency of exposure. Exposure to pure benzene was not significantly related to NHL (OR=3.4 (0.8 to 15.0)). The highest maximum intensities of benzene exposure were associated with diffuse large cell lymphoma (OR=2.1 (1.0 to 4.6)).ConclusionThe results of the present study provide estimates compatible with the hypothesis that exposures to pure benzene and high benzene intensities may play a role in some NHL. There was no evidence for a role of other organic solvents in the occurrence of LN.
Deep structures and seismic stratigraphy of the Egyptian continental margin from multichannel seismic data
Authors: Caméra Laurent , Ribodetti Alessandra , Mascle Jean 
Published: September 2010

Abstract

Regional multichannel seismic reflection (MCS) profiles across the Egyptian continental slope, offshore the Nile delta, were recorded during the MEDISIS survey (conducted in 2002 on board the R/V
Nadir
). The results of this survey allow an interpretation of the overall structure and evolution of this passive continental margin. The MCS data were processed using an amplitude preserving pre-stack depth migration technique, which has the advantage of providing a quantitative, and geometrically correct, image of seismic horizons. Well-defined reflecting events allow the identification of three main seismic units. The upper unit (a 7 km thick) is interpreted as the post-rift sedimentary cover of the margin; it includes an undisturbed Middle Cretaceous to Upper Miocene sedimentary pile, covered by thick Messinian (latest Miocene) salt-rich layers and by Pliocene to Quaternary sediments, locally intensively deformed by gravity tectonics. The underlying intermediate acoustic unit (6 km thick on average) is interpreted as the Mesozoic syn-rift sedimentary cover of the margin; the end of the last rifting event is marked by a strong angular unconformity, tentatively of Aptian age. The lower unit may correspond to the thinned continental crust of Africa (12 km thick on average in the study area) and its pre-rift cover. Its base is identified by strong, discontinuous reflector packages about 23–25 km below sea floor, interpreted as indicative of the Moho.
Plasma haemoxygenase-1 in coronary artery disease
Authors: Idriss Naglaa , Lip Gregory , Balakrishnan Balu , Jaumdally Rumi , Boos Christopher , Blann Andrew 
Published: September 2010

SummaryIt was the aim of this study to determine plasma haemoxygenase-1 (HO-1) across the spectrum of health, angina but normal coronary arteries (NCA), stable coronary artery disease (CAD), and acute coronary syndromes (ACS), and relationships with angiogenin, matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1, and vascular endothelial growth factor. Plasma markers were measured (ELISA) in peripheral venous citrated plasma from 50 healthy subjects, 30 with NCA, 70 with stable CAD and 24 with an ACS, and from patient’s aortic root, coronary ostium, coronary sinus and femoral artery. Human umbilical vein endothelial cells (HUVECs) were cultured with or without tumour necrosis factor (TNF), and platelets were probed. HO-1 was raised in stable CAD (p<0.05) and increased further in ACS (p<0.01) compared to healthy controls and NCA. HO-1 correlated only with MMP-9, and then only in the healthy controls. There were no major differences from cardiac or peripheral sites. HO-1 was present in HUVECs and 24-hour HUVEC supernatants but release was abolished by TNF. Platelets had no HO-1. In conclusion, HO-1 is raised in stable CAD and ACS and may arise from the endothelium but not the platelet. This may have implications for our understanding of the pathophysiology of CAD and its acute presentation as ACS.
Studies on Fletcher trait and Fitzgerald trait
Authors: Saito Hidehiko 
Published: September 2010

SummaryThe way by which contact of blood with foreign surface accelerates clotting has been elucidated from the discovery of four rare disorders of blood coagulation; Hageman trait, plasma thromboplastin antecedent (PTA) deficiency, Fletcher trait, and Fitzgerald trait. Interestingly, it was unexpectedly found that Fletcher factor is plasma prekallikrein and Fitzgerald factor is high-molecular-weight kininogen; components of the kinin-generating system, thus disclosing intimate relationships among clotting, fibrinolysis and kinin generation which may be viewed as body’s defense reactions against injury. This review mainly reflects our research on Fletcher trait and Fitzgerald trait during the 1970s in Cleveland.
2B or not to be – The 45-year saga of the Montreal Platelet Syndrome
Authors: Rand Margaret , Jackson Shannon , Poon Man-Chiu 
Published: September 2010

SummaryOver 45 years ago, Montreal Platelet Syndrome was first described as a rare inherited platelet disorder characterised by macrothrombocytopenia with spontaneous platelet clumping, abnormal platelet shape change upon stimulation and a defect in platelet calpain. This syndrome has now been reclassified as type 2B von Willebrand disease with the V1316M VWF mutation in the only kindred ever reported. We herein revisit the historical platelet characteristics originally described in Montreal Platelet Syndrome in light of the new diagnosis. This paper will review the 45-year saga of Montreal Platelet Syndrome, a story that highlights the value of revisiting a rare diagnosis to look for a more common explanation.
Differential endocytosis of tissue plasminogen activator by serpins PAI-1 and PAI-2 on human peripheral blood monocytes
Authors: Lee Jodi A. , Croucher David R. , Ranson Marie 
Published: September 2010

SummaryGeneration of the broad spectrum protease plasmin is facilitated by the tissue (t-PA) and urokinase (u-PA) plasminogen activators, within multiple physiological and disease states. Finely tuned control of this proteolytic cascade is exerted by the plasminogen activator inhibitors type-1 (PAI-1/SERPINE1) and 2 (PAI-2/SERPINB2). Expression of this network of activators and inhibitors by cells of myeloid lineage appears to be highly interchangeable between physiological environments, and whilst the role of PAI-1 and PAI-2 in regulating u-PA-dependent functions is well established, the interaction between t-PA and PAI-2 on these cell types is poorly characterised. To this end, we used freshly isolated peripheral blood monocytes (PBM) as a model of a t-PA-dependent cellular environment. We demonstrate that while both PAI-1 and PAI-2 could inhibit surface-bound t-PA and are internalised predominately via low-density-lipoprotein receptor family members, PAI-1 enhanced the endocytosis of t-PA, whereas PAI-2 did not. Surface plasmon resonance analyses revealed differential binding affinities between the very-low-density-lipoprotein receptor and t-PA and t-PA:PAI-1 complexes in addition to those previously described with low-density-lipoprotein receptor-related protein. Moreover, t-PA:PAI-2 bound to both endocytosis receptors with similar kinetics to t-PA. These differential biochemical interactions between t-PA and the t-PA:PAI complexes may underlie the observed differences in endocytosis mechanisms on the PBMs. This suggests that while PAI-1 and PAI-2 function similarly in the control of cellular plasmin generation by t-PA, they may have disparate effects on the alternative functions of t-PA via modulation of its engagement with endocytosis receptors.
Von Willebrand factor-containing factor VIII concentrates and inhibitors in haemophilia A
Authors: Lippi Giuseppe , Franchini Massimo 
Published: September 2010

SummaryThe development of inhibitors that neutralise the function of factor VIII (FVIII) is currently not only the most challenging complication associated with the treatment of haemophilia A but it also increases the disease-related morbidity as bleeding episodes do not respond to standard therapy. The main short-term goal of the treatment of inhibitor patients is to control bleeding episodes while the long-term one is to permanently eradicate the inhibitor by immune tolerance induction, particularly in the case of high-titer antibodies. Due to some in vitro studies and clinical observations, some investigators have suggested that FVIII concentrates containing von Willebrand factor (VWF) may be less immunogenic than high-purity or recombinant FVIII products. It has also been suggested that success rates for immune tolerance induction are higher when plasma-derived FVIII products are used. The currently available data from laboratory and clinical studies on the role of VWF in inhibitor development and eradication in haemophilia A is critically analysed in this review. As a result, we have not found definitive evidence supporting a role for product type on inhibitor incidence and inhibitor eradication in haemophilia A patients.
Platelets enhance lymphocyte adhesion and infiltration into arterial thrombus
Authors: Hu Hu , Zhu Linjing , Huang Zhangsen , Ji Qiushang , Chatterjee Madhumita , Zhang Wei , Li Nailin 
Published: September 2010

SummaryLymphocytes are present in atherosclerotic lesion. We hypothesise that platelets may facilitate lymphocyte infiltration into the arterial wall. Reconstituted human blood or whole blood was perfused through a collagen-coated parallel-plate flow chamber at different shear rates. Adhered platelets markedly enhanced lymphocyte adhesion that increased lymphocyte deposition from 10 ± 3 cells/mm2 of platelet-depleted blood to 38 ± 11 cells/mm2 of platelet-containing blood at the arterial shear rate of 500 s-1. Platelet-dependent lymphocyte adhesion was inhibited by P-selectin, CD40L, and GPIIb/IIIa-blocking agents, suggesting the involvement of multiple adhesion molecules in this heterotypic interaction. Lymphocyte deposition was more marked among T cells, and seen in both small and large cells. B and natural killer cell adhesion was, however, mainly seen in small cells. Platelet-conjugation facilitated lymphocyte adhesion, as suggested by the selective deposition of platelet-conjugated lymphocytes. In a mouse model of arterial thrombosis, FeCl3-induced thrombus formation markedly enhanced lymphocyte adhesion and infiltration into platelet thrombi, which was abolished by GPIIb/IIIa inhibition. In conclusion, platelets support lymphocyte adhesion under arterial flow conditions, which is selective among T cells and involves multiple adhesion molecules. Our data imply that platelets may facilitate the recruitment of circulating lymphocytes at the arterial injured sites.