bluuebunny/crossref_metadata_2025_split huggingface dataset:
Promotion of a social prescribing pathway to general practitioners in a rural area (a feasibility study protocol)
Authors: Ridge Andrew , Peterson Gregory , Seidel Bastian , Nash Rosie 
Published: May 2024

PurposePsychosocial problems, including social isolation and loneliness, are prevalent in rural communities and can impact the use of health services and health outcomes. Current approaches to managing patients with predominantly psychosocial issues may not be the most appropriate. Social prescribing (SP) is a relatively new way of linking patients with sources of non-medical support within the community. Emerging literature suggests that community-based, non-medical activities are an effective and preferred approach to managing psychosocial problems. However, there is little evidence describing the attitudes of general practitioners (GPs) towards formal SP pathways.Design/methodology/approachThis research will occur in a general practice in a rural area of Tasmania, Australia. The project will deliver an education module to rural GPs to highlight the benefits of SP and provide a streamlined pathway for referring patients to community support hubs. Existing community organisations will act as “link workers” to connect patients with suitable community activities. GPs will complete a baseline and follow-up survey to measure their perception of SP and the acceptability, feasibility and appropriateness of such an intervention.FindingsThe acceptability, feasibility and appropriateness of the pathway will be assessed using published measures. Free-text responses to open-ended questions will be used to complement the quantitative data. A hybrid effectiveness-implementation method will be used to gather information about the rate of uptake and quality of the SP referral process and identify barriers and facilitators of the process in a real-world setting.Research limitations/implicationsWhile qualitative data for SP programmes is predominantly positive, quantitative data is lacking. Although the planned project is relatively short, it will provide a basis for future SP programme implementation and guide the approach to data collection and implementation assessment.Social implicationsThe barriers to and facilitators of introducing a SP programme in a rural general practice setting may be used to guide the development and implementation of future large-scale SP interventions. This research is both timely and relevant as the problem of social isolation and loneliness, especially in rural areas of Australia, is becoming more well-recognised as a driver of poor health and unnecessary health service usage.Originality/valueUsing SP to address psychosocial risks may reduce healthcare burden and costs. Few SP programmes have been delivered and formally assessed in Australia, and the best way to implement SP locally remains unclear. By delivering a SP intervention in a rural setting and assessing GPs’ responses, future SP projects will be better able to design and integrate social and medical care services.
Evaluation of constraints for investment in NOx emission technologies: case study on Greek bulk carrier owners
Authors: Karahalios Hristos 
Published: May 2024

PurposeThe maritime industry is the transport mode that contributes most to air pollution. The International Maritime Organization (IMO) identified the reduction of air pollution by ships as a crucial issue. Since 1 January 2020, ships have had to adopt strategies and new technologies to eliminate air pollution. However, ship compliance with nitrate oxide (NOx) emission restrictions is more challenging. This paper aims to identify shipowners' challenges in investing in new technologies.Design/methodology/approachThis paper applied a hybrid methodology combining a survey, a balanced scorecard and fuzzy analytic hierarchy process (F-AHP) to identify and evaluate constraints and weights in investment decision-making for NOx technologies. A survey was carried out to validate constraints.FindingsA survey was carried out, representing 5.1% of Greek-owned ships by deadweight capacity. The findings provide a weighted list of seven crucial technical and economic constraints faced by ship operators. The constraints vary from ship retrofit expenditure to crew training and waste management. Additionally, NOx emission technologies were compared. It was found that liquefied natural gas is the preferred investment option for the survey participants compared with selective catalytic reduction, exhaust gas recirculation and batteries.Originality/valueSeveral studies have dealt with the individual technical feasibility of NOx reduction technologies. However, apart from technical feasibility for a shipowner, the selection of a NOx technology has several managerial and safety risks. Therefore, the originality of this paper is to reveal those constraints that have a higher weight on shipowners. With this cost-benefit approach, investment challenges for ship operators are revealed. Policymakers can benefit from the results of the employed methodology.
ESG, innovation, and economic growth: an empirical evidence
Authors: Mohd Daud Siti Nurazira , Ghazali Nur Syazwina , Mohammad Ismail Nur Hafizah 
Published: May 2024

Purpose
This paper aims to examine the relationships among environmental, social and governance (ESG) practices, innovation and economic growth in five Asian countries from 1990 to 2020.

Design/methodology/approach
The study innovatively constructed the ESG index at the country level by using frequency statistics on text mining and factor analysis for each country over time. In addition, this study used the autoregressive distributed lag method to establish a long-term relationship.

Findings
The authors discovered that ESG practices among corporate entities significantly impact economic growth in Malaysia, the Philippines and Singapore. Specifically, the environmental component positively affects the growth of Malaysia, Thailand and the Philippines, while the governance components of ESG contribute to Thailand’s economic growth. The authors also discovered that innovation improves countries’ economic growth, thus offering policy insights into promoting ESG practices and stimulating the ecosystem for innovation.

Originality/value
The paper fills the gap left in previous inconclusive findings on the association between ESG practices and country growth.
WeChat gamification: mobile payment impact on word of mouth and customer loyalty
Authors: Butt Asad Hassan , Ahmad Hassan , Muzaffar Asif , Irshad Waseem , Mumtaz Muhammad Usman , Zubair Ahmad Khan Talha 
Published: May 2024

Purpose
This study aims to investigate how gamification, namely, WeChat’s cultural gifting function, improves emotional involvement among three generations (Y, X and silver) in mobile payments. It draws attention to the beneficial effects of cultural components and digital intimacy on gamified mobile payment systems.

Design/methodology/approach
The data were collected from Y, X and silver generation in Dalian, China. The users were well equipped with the WeChat pay features and had experience. The PLS-SEM software was used to assess the data.

Findings
The findings show that consumer word of mouth and loyalty are positively impacted by perceived utility, fun, and enjoyment. Besides, gamification components like fun and playfulness have a favourable effect on how useful mobile payments are judged to be. It demonstrates how delighted and ecstatic users are with WeChat Hongbao. In addition, the positive moderation effect of intimacy on the hypothesised connections shows that all three generations are likely to accept gamified money features. These results provide a substantial contribution to our comprehension of gamification in the context of mobile payment services for all three generations.

Originality/value
The study is distinctive because it focuses on how China’s three generations use WeChat Pay for routine transactions. The framework confirms that the gamification elements improve user performance and encourage continued usage of mobile payment systems.
Uridine phosphorylase‐1 promotes cell viability and cell‐cycle progression in human epidermal keratinocytes via the glycolytic pathway
Authors: Xiao Xiaoqing , Qiu Tianwen , Cheng Qiong , Wang Wenyu , Fan Chunyan , Zuo Fuguo 
Published: May 2024

AbstractGlycolysis is vital for the excessive proliferation of keratinocytes in psoriasis, and uridine phosphorylase‐1 (UPP1) functions as an enhancer of cancer cell proliferation. However, little is known about whether UPP1 promotes keratinocyte proliferation and accelerates psoriasis development. This study revealed that UPP1 facilitates cell viability and cell‐cycle progression in human epidermal keratinocytes (HEKs) by modulating the glycolytic pathway. Bioinformatics analysis of UPP1 gene expression and its correlation with the Reactome revealed that UPP1 mRNA expression, cell‐cycle progression, the interleukin‐6 (IL‐6)/Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) pathway and glycolysis were positively associated with psoriasis. Cell proliferation, the cell cycle and glycolysis were evaluated after UPP1 was silenced or overexpressed. The results showed that UPP1 overexpression increased cell proliferation, cell‐cycle progression and glycolysis, which was contrary to the effects of UPP1 silencing. However, the STAT3 inhibitor diminished UPP1 expression because STAT3 can bind to the UPP1 promoter. In conclusion, UPP1 was significantly activated by the IL‐6/STAT3 pathway and could modulate glycolysis to regulate cell proliferation and cell‐cycle progression in keratinocytes during the development of psoriasis.
The N6‐methyladenosine methylation landscape stratifies breast cancer into two subtypes with distinct immunological characteristics
Authors: Chen Yang , Hou Yijiang , Li Shuguang , Qin Wenxing , Zhang Jian 
Published: May 2024

AbstractN6‐methyladenosine (m6A) methylation modification affects the tumorigenesis and metastasis of breast cancer (BC). This study investigated the association between m6A regulator‐mediated methylation modification patterns and characterization of the tumour microenvironment in BC, as well as their prognostic importance. Public gene expression data and clinical annotations were collected from The Cancer Genome Atlas (TCGA) database, the Gene Expression Omnibus website and the METABRIC program. We analysed the genetic expression, gene–gene interactions, gene mutations and copy number variations using R software. The data were screened for risk genes using the Cox risk regression model, and we developed an algorithm for risk score and its predictive value. Compared to adjacent normal tissue, we identified 16 differentially expressed m6A regulators in BC, including six writers and 10 readers. Under unsupervised clustering, two distinguished modification patterns were identified, cluster C1 and C2. Compared to m6A cluster C2, cluster C1 was found to be more involved in immune‐related pathways, with a relatively higher immune score and stromal score (P < 0.05). Patients were divided into two groups based on their risk scores for survival analysis. The patients in the high‐risk score group had significantly worse overall survival than patients in the low‐risk score group, (P < 0.0001). The TCGA database validation revealed the same prognostic tendency. In summary, our study showed distinct m6A regulator modification patterns contribute to the immunological heterogeneity and diversity of BC. The development of m6A gene signatures and the m6A score aid in the prognostic prediction of patients with BC.
Effect of ultrasound‐assisted L‐lysine treatment on pork meat quality and myofibrillar protein properties during postmortem aging
Authors: Xu Shuangyi , Guo Xiuyun , Fu Chao , Wang Jipan , Meng Xiangren , Hui Teng , Peng Zengqi 
Published: May 2024

AbstractThis paper aimed to investigate the effects of ultrasound‐assisted L‐lysine treatment on meat quality and myofibrillar proteins (MPs) properties of pork longissimus dorsi during postmortem aging. The results revealed that the L‐lysine (Lys) and/or ultrasound treatment significantly increased (p < 0.05) the water‐holding capacity and tenderness of the pork during postmortem aging, while the ultrasound‐assisted Lys treatment had the lowest cooking loss, pressurization loss, Warner–Bratzler shear force, and hardness. In addition, L‐lysine and/or ultrasound treatment increased (p < 0.05) pH value, T21, and myofibrillar fragmentation index, while the ultrasound‐assisted Lys treatment had the highest value. Meanwhile, the protein solubility was increased with Lys and/or ultrasound treatment during postmortem aging, and ultrasound‐assisted Lys treatment had the highest solubility, reaching 88.19%, 92.98%, and 91.73% at 0, 1, and 3 days, respectively. The result of protein conformational characteristics showed that Lys and/or ultrasound treatment caused the unfolding of the α‐helix structure, resulting in the exposure of more hydrophobic amino acids and buried sulfhydryl groups, ultimately enhancing MPs solubility. In summary, ultrasound‐assisted Lys treatment altered the structure of MPs, resulting in the enhancement of the water‐holding capacity and tenderness of the pork.Practical ApplicationThis study showed that ultrasound‐assisted L‐lysine (Lys) treatment could enhance the water‐holding capacity and tenderness of pork during postmortem aging. The results might provide a reference for the application of ultrasound‐assisted Lys treatment on the improvement of pork meat quality. To facilitate practical applications in production, the development of medium and large‐sized ultrasound equipment for conducting small‐scale and pilot experiments is crucial for future research.
Alcohol use disorder as a moderator of the relationship between posttraumatic stress disorder and suicidality among military personnel
Authors: Walton Thomas O. , Graupensperger Scott , Walker Denise D. , Kaysen Debra 
Published: May 2024

AbstractBackgroundAlcohol use disorder (AUD), posttraumatic stress disorder (PTSD), and suicide are substantial public health concerns among military service members, yet the nature of their relationships is not well understood. Here, we tested the hypothesis that AUD moderates the relationship between PTSD symptom severity and suicidal ideation.MethodsThis secondary analysis uses data collected at baseline for a randomized clinical trial. The sample consists of 160 active‐duty service members from three service branches (Army, Air Force, and Navy). All participants met diagnostic criteria for PTSD and were not engaged in evidence‐based PTSD treatment at the time of enrollment. Zero‐inflated Poisson generalized linear regression models were used to test the associations of PTSD and AUD symptom severity with the presence and severity of suicidal ideation.ResultsFindings suggest that AUD symptom severity moderates (i.e., amplifies) the relationship between PTSD symptoms and severity of suicidal ideation among military personnel with untreated PTSD. Among service members with mild or absent AUD, we found no significant association between PTSD symptoms and the severity of suicidal ideation. However, when AUD severity was average (i.e., sample mean) or high (mean + 1SD), PTSD symptoms were significantly positively associated with the severity of suicidal ideation.ConclusionsThis study highlights the importance of assessing AUD and PTSD as a part of suicide risk evaluations of veterans. The results also provide strong support for the maintenance and further development in the military health system of treatment programs that simultaneously address AUD and PTSD comorbidity.
The long‐term adherence following the end of Community Treatment Order: A systematic review
Authors: Cossu Giulia , Kalcev Goce , Sancassiani Federica , Primavera Diego , Gyppaz Davide , Zreik Thurayya , Carta Mauro Giovanni 
Published: May 2024

AbstractBackgroundThe community treatment order (CTO) is designed to deliver mental healthcare in the community and has been introduced in around 75 jurisdictions worldwide. It constitutes a legal obligation in which individuals with severe mental illness must adhere to out‐of‐hospital treatment plans. Despite intense criticism and the debated nature of published evidence, it has emerged as a clinical and policy response to frequent hospital readmissions and to enhance adherence in cases where there is refusal of pharmacological treatments. This systematic review outlines findings on CTO long‐term adherence, after mandatory outpatient treatment has ended, in studies that include people with psychiatric disorders.MethodFollowing PRISMA guidelines, we performed a review of published articles from PubMed, PsycINFO, EMBASE, and CINAHL up to January 15, 2023. We included studies that assessed adherence after CTO ends. The study is registered with PROSPERO number CRD42022360879.ResultsSix independent studies analyzing the main indicators of long adherence: engagement with services and medication adherence, were included. The average methodological quality of the studies included is fair. Long‐term adherence was assessed over a period ranging from 11 to 28 months. Only two studies reported a statistically significant improvement. Regarding the remaining studies, no positive correlation was observed, except for certain subgroup samples, while in one study, medication adherence decreased.ConclusionScientific evidence supporting the hypothesis that CTO has a positive role on long‐term adherence post‐obligation is currently not sufficient. Given the importance of modern recovery‐oriented approaches and the coercive nature of compulsory outpatient treatment, it is necessary that future studies ensure the role of CTO in effectively promoting adherence.
Multi‐omic integration reveals alterations in nasal mucosal biology that mediate air pollutant effects on allergic rhinitis
Authors: Irizar Haritz , Chun Yoojin , Hsu Hsiao‐Hsien Leon , Li Yan‐Chak , Zhang Lingdi , Arditi Zoe , Grishina Galina , Grishin Alexander , Vicencio Alfin , Pandey Gaurav , Bunyavanich Supinda 
Published: May 2024

AbstractBackgroundAllergic rhinitis is a common inflammatory condition of the nasal mucosa that imposes a considerable health burden. Air pollution has been observed to increase the risk of developing allergic rhinitis. We addressed the hypotheses that early life exposure to air toxics is associated with developing allergic rhinitis, and that these effects are mediated by DNA methylation and gene expression in the nasal mucosa.MethodsIn a case–control cohort of 505 participants, we geocoded participants' early life exposure to air toxics using data from the US Environmental Protection Agency, assessed physician diagnosis of allergic rhinitis by questionnaire, and collected nasal brushings for whole‐genome DNA methylation and transcriptome profiling. We then performed a series of analyses including differential expression, Mendelian randomization, and causal mediation analyses to characterize relationships between early life air toxics, nasal DNA methylation, nasal gene expression, and allergic rhinitis.ResultsAmong the 505 participants, 275 had allergic rhinitis. The mean age of the participants was 16.4 years (standard deviation = 9.5 years). Early life exposure to air toxics such as acrylic acid, phosphine, antimony compounds, and benzyl chloride was associated with developing allergic rhinitis. These air toxics exerted their effects by altering the nasal DNA methylation and nasal gene expression levels of genes involved in respiratory ciliary function, mast cell activation, pro‐inflammatory TGF‐β1 signaling, and the regulation of myeloid immune cell function.ConclusionsOur results expand the range of air pollutants implicated in allergic rhinitis and shed light on their underlying biological mechanisms in nasal mucosa.
Holmium:yttrium‐aluminium‐garnet laser with MOSES technology is more efficient than thulium fibre laser in supine mini‐percutaneous nephrolithotomy
Authors: Vergamini Lucas B. , Ito Willian , Choi B Nicholas , Du Holly E. , Sardiu Mihaela E. , Neff Donald , Duchene David A. , Molina Wilson R. , Whiles Bristol B. 
Published: May 2024

ObjectivesTo address the paucity of literature comparing outcomes achieved with utilisation of the high‐power holmium:yttrium‐aluminium‐garnet (Ho:YAG) laser with MOSES technology vs those achieved with the thulium fibre laser (TFL) in mini‐percutaneous nephrolithotomy (PCNL).MethodsA retrospective review was performed of patients undergoing supine mini‐PCNL between August 2021 and May 2023. Exclusion criteria were urinary diversion, simultaneous utilisation of >1 laser platform, use of any other form of fragmentation, and ureteric stones. The Ho:YAG platform (Lumenis Pulse P120H™ with MOSES technology, 120W; Boston Scientific®) and the TFL (Soltive SuperPulsed Thulium Fibre [SPTF], 60W; Olympus®) were compared. Data on stone‐free rate (SFR) were determined by computed tomography performed on the first postoperative day and presented as absence of stone fragments, no fragments larger than 2 mm, or no fragments larger than 4 mm.ResultsA total of 100 patients met the inclusion criteria, 51 mini‐PCNLs with the Ho:YAG laser and 49 with the SPTF laser. No significant differences in demographics or stone characteristics were detected between the two groups. The Ho:YAG laser utilised less energy and time, resulting in higher ablation efficiency (P < 0.05) and less total operating time (P < 0.05). Overall, there was no difference in SFR in any category between the Ho:YAG group and the SPTF group (no fragments: relative risk [RR] 0.81, 95% confidence interval [CI] 0.59–1.12, P = 0.21; fragments <2 mm: RR 0.86, 95% CI 0.67–1.10, P = 0.23; fragments <4 mm: RR 0.96, 95% CI 0.80–1.15, P = 0.67).ConclusionsAlthough we observed an equivalent postoperative SFR, this study supports a shorter operating time and greater intra‐operative laser efficiency with the Ho:YAG laser over the SPTF laser in mini‐PCNL.
Severe adrenal insufficiency in six neonates with normal newborn screening for CAH
Authors: Kurt Ilknur , Eser Metin , Kahveci Ahmet , Ucar Ahmet , Bulus Derya , Ozcabi Bahar , Guran Omer , Karagozlu Selen , Ersoy Aysenur , Demir Senol , Geckinli Bilge , Guran Tulay 
Published: May 2024

AbstractBackgroundNewborn screening (NBS) reduces the risk of mortality in congenital adrenal hyperplasia (CAH), mainly due to the salt‐wasting form of 21‐hydroxylase deficiency. There is limited knowledge regarding the results of NBS in non‐CAH primary adrenal insufficiency (non‐CAH PAI).Patients and MethodsClinical and NBS for CAH data of neonates who were diagnosed with non‐CAH PAI between January and December 2022 were examined.ResultsPatients (n = 6, 4 females) were presented with severe hyperpigmentation (n = 6), hypoglycemia (n = 4), hyponatremia (n = 3), hyperkalemia (n = 1), respiratory distress syndrome (n = 1) between 3rd hour to 2 months of life. All had normal NBS results. The median first‐tier 17‐hydroxyprogesterone (17OHP) concentration in NBS for CAH was 0.14 ng/mL (range; 0.05−0.85). Molecular studies revealed biallelic mutations in the MC2R (n = 4; 3 homozygous, 1 compound heterozygous), MRAP (n = 1) and STAR (n = 1) genes. Glucocorticoid with or without mineralocorticoid replacement was initiated once the diagnosis of non‐CAH PAI was established.ConclusionNeonates with non‐CAH PAI have always normal NBS due to persistently low 17OHP, even when these newborn infants are severely symptomatic for adrenal insufficiency. Clinicians should be alert for signs of adrenal insufficiency in neonates, even if the patient has a ‘normal’ screening for CAH, so as not to delay diagnosis and treatment. This fact should be kept in mind particularly in countries where these conditions are more common than elsewhere.