bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neglected Spheno-orbital Meningioma Presenting with Unilateral Blindness
Authors: Haradhan Deb Nath  , KH Olinur Razib  , Rathin Halder  , Ataur Rahman  , Motasimul Hasan  , Abu Naim Wakil Uddin  , Md Rabiul Karim  , Sudip Barua  , SK Farhad Munir  
Published: May 2024

Sphenoorbital meningiomas (SOM) constitutes 9% of all intracranial meningiomas and are originated from sphenoid wing dura. They are also called en plaque meningioma. They cause hyperostosis of involved bone and their soft tissue growth may spread the orbit, the infratemporal fossa, and the temporal fossa. Most patients with SOM are middle- aged women and most commonly presents with unilateral, nonpulsating, progressive proptosis. Recently a woman with unilateral progressive proptosis from a remote area of Bangladesh presented to us with blindness of her left eye due to diagnostic delay. After thorough evaluation and imaging studies, she was diagnosed with a large spheno-orbital meningioma with extensive bony involvement of skull base and orbit.
Objective: This report highlights the necessity of creating awareness among optometrists, undergraduate medical students as well as and ophthalmologists who are practicing in remote areas of Bangladesh about clinical presentation of sphenoorbital meningiomas which is a benign lesion but may be a cause of unilateral blindness if remain undiagnosed for long
Bang. J Neurosurgery 2023; 13(1): 51-54
Exploring the potential of fennel (<i>Foeniculum vulgare</i> Mill.) as a valuable medicinal plant: a comprehensive (review)
Authors: Bourakba S. , Marakhova A. I. , Stanishevskiy Ya. M. , Vasilenko I. A. , Zhilkina V. Y. 
Published: May 2024

Introduction. Foeniculum vulgare Mill., commonly known as fennel or drugstore dill, is very common as one of the world's oldest spice plants, which has significant economic importance and wide application in the pharmaceutical industry. In medical practice, the fruits of this plant are mainly used, which are included in the State Pharmacopoeia of the XIV edition and are a source of essential oil. They are used as an antispasmodic and carminative agent in the form of an infusion. Fennel grass harvested before flowering is used for food, as well as fruits, stems and inflorescences of the plant as a seasoning.Text. The purpose of this study is to summarize scientific papers on the morphological characteristics, phytochemical compounds, therapeutic properties and basic mechanisms of pharmacological activity of F. vulgare. A systematic literature search was conducted using relevant keywords such as "fennel", "Foeniculum vulgare Mill.", "therapeutic" and "pharmacology" in well-known databases, including ScienceDirect, Scopus, EBSCO and Medline. The search covered articles published before April 25, 2023 in available journals. The results of the study showed that fennel has a wide range of pharmacological properties, including antioxidant, anti-cancer, anti-inflammatory, antifungal, antibacterial and estrogenic effects. These effects can be explained by the presence of aromatic compounds, in particular anethole, estragole and fenchone, which are abundantly present in fennel.Conclusion. The diverse pharmacological properties and rich chemical composition of fennel make it a promising raw material for the development of new medicines. Further study of the therapeutic potential of fennel through in vivo and in vitro studies will contribute to the establishment of mechanisms of pharmacological action of biologically active substances (BAS) of fennel.
Survival After Ditching in Motorized Aircraft, 1989–2022
Authors: Schick Volker C. , Boyd Douglas D. , Hippler Catherina , Hinkelbein Jochen 
Published: May 2024

INTRODUCTION: Although an unintended aircraft landing on water (referred to as ditching) is a rare event, the potential for occupant injury/fatality increases immediately following the event due to adverse conditions. However, to date, few studies have addressed the subject. Herein, ditching events and post-ditching survival were investigated.
METHODS: Ditchings (1982–2022) in the United States were identified from the National Transportation Safety Board database. Occupant injury severity, aircraft type, pilot experience, flight conditions, and number of occupants were extracted. Poisson distribution, the Chi-squared test (2-tailed), Mann-Whitney U test, and Kruskal-Wallis one-way analysis of variance were employed.
RESULTS: A total of 96 ditchings were identified. A systematic survey was hampered by the lack of a standardized reporting matrix in the reports. In total, 77 reports were included in the analysis. Across all ditchings, 128 of 169 (76%) occupants survived ditching and were rescued. Importantly, the initial ditching event was survived by 95% of all occupants. However, 32 (19%) occupants died post-ditching by drowning (21/32 cases) or for undetermined reasons. Considering probability per ditching event, in 26 (34%) of all ditchings, one or more occupants was/were fatally injured.
DISCUSSION: Initial survival of the emergency ditching is high. Drowning was the leading cause of death after ditching and reduced the overall survival to 76%. Further investigation is needed to identify risk factors for fatal outcomes and/or improve probability of survival after ditching.
Schick VC, Boyd DD, Hippler C, Hinkelbein J. Survival after ditching in motorized aircraft, 1989–2022. Aerosp Med Hum Perform. 2024; 95(5):254–258.
Modern Magnetic Resonance Imaging Modalities to Advance Neuroimaging in Astronauts
Authors: Berger Lila , Burles Ford , Jaswal Tejdeep , Williams Rebecca , Iaria Giuseppe 
Published: May 2024

INTRODUCTION: The rapid development of the space industry requires a deeper understanding of spaceflight’s impact on the brain. MRI research reports brain volume changes following spaceflight in astronauts, potentially affecting cognition. Recently, we have demonstrated that this evidence of volumetric changes, as measured by typical T1-weighted sequences (e.g., magnetization-prepared rapid gradient echo sequence; MPRAGE), is error-prone due to the microgravity-related redistribution of cerebrospinal fluid in the brain. More modern neuroimaging methods, particularly dual-echo MPRAGE (DEMPRAGE) and magnetization-prepared rapid gradient echo sequence utilizing two inversion pulses (MP2RAGE), have been suggested to be resilient to this error. Here, we tested if these imaging modalities offered consistent segmentation performance improvements in some commonly employed neuroimaging software packages.
METHODS: We conducted manual gray matter tissue segmentation in traditional T1w MRI images to utilize for comparison. Automated tissue segmentation was performed for traditional T1w imaging, as well as on DEMPRAGE and MP2RAGE images from the same subjects. Statistical analysis involved a comparison of total gray matter volumes for each modality, and the extent of tissue segmentation agreement was assessed using a test of similarity (Dice coefficient).
RESULTS: Neither DEMPRAGE nor MP2RAGE exhibited consistent segmentation performance across all toolboxes tested.
DISCUSSION: This research indicates that customized data collection and processing methods are necessary for reliable and valid structural MRI segmentation in astronauts, as current methods provide erroneous classification and hence inaccurate claims of neuroplastic brain changes in the astronaut population.
Berger L, Burles F, Jaswal T, Williams R, Iaria G. Modern magnetic resonance imaging modalities to advance neuroimaging in astronauts. Aerosp Med Hum Perform. 2024; 95(5):245–253.
Fatigue Risk Management Preferences for Consumer Sleep Technologies and Data Sharing in Aviation
Authors: Devine Jaime K. , Choynowski Jake , Hursh Steven R. 
Published: May 2024

INTRODUCTION: Employees from any type of aviation services industry were asked to give their opinions about the usefulness of consumer sleep technologies (CSTs) during operations and their willingness to share data from CSTs with their organizations for fatigue risk management purposes under a variety of circumstances.
METHODS: Respondents provided information about position in aviation and use of CST devices. Respondents ranked sleep issues and feedback metrics by perceived level of importance to operational performance. Respondents rated their likelihood to share data with their organization under a series of hypothetical situations.
RESULTS: Between January-July 2023, 149 (N = 149) aviation professionals responded. Pilots comprised 72% (N = 108) of respondents; 84% (N = 125) of all respondents worked short- or medium-haul operations. “Nighttime operations” and “inconsistent sleep routines” ranked as the most important issues affecting sleep. “Sleep quality history” and “projected alertness levels” ranked as most important feedback metrics for personal management of fatigue. Respondents were split between CST users (N = 64) and nonusers (N = 68). CST users did not indicate a strong preference for a specific device brand. The most-reported reason for not using a CST was due to not owning one or no perceived need. Respondents indicated greater likelihood of data sharing under conditions where the device was provided to them by their organization.
DISCUSSION: These results suggest that aviation professionals are more concerned about schedule-related disturbances to sleep than they are about endogenous sleep problems. Organizations may be able to increase compliance to data collection for fatigue risk management by providing employees with company-owned CSTs of any brand.
Devine JK, Choynowski J, Hursh SR. Fatigue risk management preferences for consumer sleep technologies and data sharing in aviation. Aerosp Med Hum Perform. 2024; 95(5):265–272.
OPTIMALISASI KOMPETENSI PEDAGOGIK GURU SEBAGAI SARANA PENGUATAN KARAKTER SISWA MELALUI KEGIATAN PEMBELAJARAN DI SDN TUIS II KABUPATEN TANGERANG
Authors: Achmad Jati Purnama , Rahmawati Euis , Pribadi Reksa Adya 
Published: May 2024

Kompetensi merupakan kemapuan terhadap suatu tugas, keterampilan, sikap, dan semua aktivitas yang diperlukan untuk mendukung suatu keberhasilan. Melalui optimalisasi kompetensi pedagogik diharapkan guru mampu membangun pengalaman belajar yang optimal dengan menjadikan sebuah proses pembelajaran sebagai sarana penguatan karakter melalui kegiatan belajar tersebut. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana proses penguatan karakter siswa melalui implementasi kompetensi pedagogik guru dan bagaimana hasil dari optimalisasi dan implementasi kompetensi pedagogik guru terhadap karakter siswa. Di dalam pelaksanaan penelitian ini menggunakan metode kualitatif dengan jenis penelitian deskriptif. Metode pengumpulan data yang digunakan dalam penelitian ini mengguanakan metode observasi dan wawancara. Selanjutnya reduksi data, penyajian data dan verifikasi dilakukan sebagai langkah dalam teknik analisis data. Dari hasil penelitian ditemukan hasil dari optimalisasi dan implementasi kompetensi pedagogik guru terhadap karakter siswa sudah baik dimana siswa mengalami perubahan dalam penerimaan materi dari guru, Siswa lebih mengerti dan memulai untuk penerapan karakter baik, Siswa lebih tertib selama berlangsungnya kegiatan pembelajaran, dan Siswa menunjukkan rasa patuh terhadap peraturan di sekolah.
Causal relationships between modifiable risk factors and polycystic ovary syndrome: a comprehensive Mendelian randomization study
Authors: Zhao Yuheng , Pang Jinglin , Fang Xingyi , Yan Zhaohua , Yang Haili , Deng Qinghua , Ma Tianzhong , Lv Mengqi , Li Yingying , Tu Ziying , Zou Lin 
Published: May 2024

BackgroundPolycystic Ovary Syndrome (PCOS) is a heritable condition with an as yet unclear etiology. Various factors, such as genetics, lifestyle, environment, inflammation, insulin resistance, hyperandrogenism, iron metabolism, and gut microbiota, have been proposed as potential contributors to PCOS. Nevertheless, a systematic assessment of modifiable risk factors and their causal effects on PCOS is lacking. This study aims to establish a comprehensive profile of modifiable risk factors for PCOS by utilizing a two-sample Mendelian Randomization (MR) framework.MethodsAfter identifying over 400 modifiable risk factors, we employed a two-sample MR approach, including the Inverse Variance Weighted (IVW) method, Weighted Median method, and MR-Egger, to investigate their causal associations with PCOS. The reliability of our estimates underwent rigorous examination through sensitivity analyses, encompassing Cochran’s Q test, MR-Egger intercept analysis, leave-one-out analysis, and funnel plots.ResultsWe discovered that factors such as smoking per day, smoking initiation, body mass index, basal metabolic rate, waist-to-hip ratio, whole body fat mass, trunk fat mass, overall health rating, docosahexaenoic acid (DHA) (22:6n-3) in blood, monounsaturated fatty acids, other polyunsaturated fatty acids apart from 18:2 in blood, omega-3 fatty acids, ratio of bisallylic groups to double bonds, omega-9 and saturated fatty acids, total lipids in medium VLDL, phospholipids in medium VLDL, phospholipids in very large HDL, triglycerides in very large HDL, the genus Oscillibacter, the genus Alistipes, the genus Ruminiclostridium 9, the class Mollicutes, and the phylum Tenericutes, showed a significant effect on heightening genetic susceptibility of PCOS. In contrast, factors including fasting insulin interaction with body mass index, sex hormone-binding globulin, iron, ferritin, SDF1a, college or university degree, years of schooling, household income, the genus Enterorhabdus, the family Bifidobacteriaceae, the order Bifidobacteriales, the class Actinobacteria, and the phylum Actinobacteria were determined to reduce risk of PCOS.ConclusionThis study innovatively employs the MR method to assess causal relationships between 400 modifiable risk factors and the susceptibility of PCOS risk. It supports causal links between factors like smoking, BMI, and various blood lipid levels and PCOS. These findings offer novel insights into potential strategies for the management and treatment of PCOS.
Extent to which weight loss contributes to improving metabolic dysfunction-associated and metabolic and alcohol related/associated steatotic liver disease: a study on Japanese participants undergoing health checkups
Authors: Fukuda Tatsuya , Okamoto Takahiro , Fukaishi Takahiro , Kawakami Akio , Tanaka Makoto , Yamada Tetsuya , Monzen Koshiro 
Published: May 2024

IntroductionThe incidence of steatotic liver disease has increased in recent years. Thus, steatotic liver disease is a major public health issue in Japan. This study investigated the association between weight reduction and the remission of metabolic dysfunction-associated steatotic liver disease (MASLD)/Metabolic and alcohol related/associated liver disease (MetALD) in Japanese individuals undergoing health checkups.MethodsThis retrospective observational study included 8,707 Japanese patients with MASLD/MetALD who underwent health checkups from May 2015 to March 2023. The participants were monitored for its remission at their subsequent visit. MASLD was diagnosed on abdominal ultrasonography and based on the presence of at least one of five metabolic abnormalities. The impact of body mass index (BMI) reduction on MASLD/MetALD remission was assessed via logistic regression analysis and using receiver operating characteristic curves.ResultsLogistic regression analysis revealed that weight loss was significantly associated with MASLD/MetALD remission. Other factors including exercise habits and reduced alcohol consumption were significant predictors of MASLD/MetALD remission in the overall cohort and in male patients. The optimal BMI reduction cutoff values for MASLD/MetALD remission were 0.9 kg/m2 and 4.0% decrease in the overall cohort, 0.85 kg/m2 and 3.9% decrease in males, and 1.2 kg/m2 and 4.5% decrease in females. In participants with a BMI of 23 kg/m2, the cutoff values were 0.75 kg/m2 and 2.7% BMI reduction.DiscussionWeight reduction plays an important role in both MASLD and MetALD remission among Japanese individuals. That is, targeting specific BMI reduction is effective. This underscores the importance of targeted weight management strategies in preventing and managing MASLD/MetALD in the Japanese population.
IL-38 promotes the development of prostate cancer
Authors: Wu Huiyan , Yang Jing , Yuan Liuhong , Tan Zhenyu , Zhang Xiuqin , Hambly Brett D. , Bao Shisan , Tao Kun 
Published: May 2024

IntroductionProstate Cancer (PCa) remains a significant concern in male cancer-related mortality. Tumour development is intricately regulated by the complex interactions between tumour cells and their microenvironment, making it essential to determine which is/are key factor(s) that influence the progression of PCa within the tumour microenvironment.Materials and methodsThe current study utilised histopathology and immunohistochemistry to determine the expression of IL-38 in PCa and analysed the correlation between the expression level of IL-38 within PCa and clinical pathological characteristics.ResultsThere was a significant increase in IL-38 expression in PCa tissues compared to adjacent non-PCa tissues (P &lt; 0.0001). In addition, IL-38 expression was significantly higher in tumour cells with a high proliferation index compared to those with a low value-added index. ROC curve analysis demonstrated that IL-38 has high specificity and sensitivity for the diagnosis of PCa (AUC=0.76). Moreover, we Probed the cellular source of IL-38 in prostate cancer tissue by immunofluorescence double staining. Additionally, within PCa, the expression of IL-38 was inversely correlated with the expression levels of CD8 and PD-1. Survival analysis revealed a significantly lower overall survival rate for PCa patients with high IL-38 expression (P=0.0069), and when IL-38 was co-expressed with CD8, the survival rate of the IL-38high/CD8low group was decreased significantly. Multivariate analysis indicated that the expression level of IL-38 and TNM staging were independent predictors of survival in PCa patients.ConclusionThese findings suggest that IL-38 plays a crucial role in the development of PCa, and the exploration of the correlation between IL-38 and various immune factors in the tumour microenvironment further reveals its mechanism of action, making it a potential target for immunotherapy in PCa.
Comparison of linear and nonlinear modeling approaches to develop an abundance index based on voyage and market data for a data-limited fishery
Authors: Yuan Tzu-Lun , Xu Haikun , Lu Bing-Jing , Chang Shui-Kai 
Published: May 2024

IntroductionWorldwide coastal fish resources face severe threats from fisheries overexploitation. However, the evaluation of abundance trends in most coastal fisheries is constrained by limited data. This study took blackmouth croaker (Atrobucca nibe), a stock depleted by coastal trawl fishery in southwestern Taiwan, as an example to showcase the development of a relative abundance index from data-limited fishery (only landing data were available).MethodsThis study employed unique data sourcing from voyage data recorders (VDRs) to estimate fishing effort (in combination with landing data to estimate the catch per unit effort, CPUE) that demonstrated the potential application in global data-limited fisheries and assessed alternative approaches for predictors of fishery-targeting practices to condition effort for producing more accurate metrics of relative abundance. The nominal CPUE was standardized using three statistical models: generalized linear model, generalized additive model (GAM), and vector-autoregressive spatiotemporal models (VASTs) with two treatments of each of the four effects: environmental (sea temperature, salinity, density of mixing layer, seafloor temperature, and chlorophyll), vessel, spatial, and targeting effects. A total of 15 models were designed and compared for these effects, and their explanatory power (EP) was evaluated using cross-validation R2 and other metrics.Results and discussionResults indicated that the targeting effect exerted the most significant influence on standardization and was suggested to be addressed through the principal component analysis (PCA) approach. Both vessel and spatial effects demonstrated considerable influence, whereas the environmental effect exhibited a limited impact, possibly due to the small fishing area in this study. Regarding models’ EP, given the nonlinear nature of the PCA algorithm and environmental data, the study highlighted the superiority of the GAM over linear-based models. However, incorporating nonlinear features in VAST (M15) makes it the most effective model in terms of predictive power in this study. Concerning the stock status, despite variations in relative CPUE trends among major models, a general declining trend since 2015 signals the potential decline of the blackmouth stock and urges fishery managers to consider further design of management measures.
Correlation study of serum lipid levels and lipid metabolism-related genes in cervical cancer
Authors: Cheng Lin , Li Zhuo , Zheng Qingmei , Yao Qin 
Published: May 2024

ObjectiveLipid metabolism plays an important role in cancer. The aim of this study was to investigate the relationship between lipid metabolism and the development of cervical cancer, and to explore the prognostic significance of lipid metabolism-related genes in patients with cervical cancer.MethodsInitially, we retrospectively collected data from 1589 cervical cancer patients treated at the Affiliated Hospital of Qingdao University, with 1589 healthy individuals from the physical examination center serving as the control group. The correlation between their serum lipid levels and cervical cancer was analyzed. Subsequently, leveraging public databases, we conducted comprehensive studies on lipid metabolism-related genes. Additionally, we analyzed RNA expression profiling and clinical information sourced from TCGA and GTEx databases. Finally, we established a prognostic model integrating 9 genes associated with lipid metabolism and generated a nomogram model using R. GO and KEGG were performed to explore the functions and pathways of lipid metabolism-related genes.ResultsOur findings revealed that patients with cervical cancer exhibited dyslipidemia, characterized by elevated levels of TC, TG, and LDL-C, alongside reduced HDL-C levels compared to controls (P&lt;0.05). Interestingly, compared with early-stage patients, advanced patients had lower HDL-C level and higher LDL-C level. Regression analysis further highlighted high TC, TG, and LDL-C as significant risk factors for cervical cancer. Then a total of 188 lipid metabolism-related genes were identified and a prognostic signature based on 9 genes was established and validated. The results of the GO and KEGG functional analysis indicated that the lipid metabolism-related genes are primarily concentrated on pathways associated with fatty acid metabolism.ConclusionOur study underscores the varying degrees of dyslipidemia observed in patients with cervical cancer, emphasizing the relevance of serum lipids in disease development. Our prognostic riskScore model predicted the overall survival time of patients based on 9 genes associated with lipid metabolism. These 9 genes may be tumor biomarkers and new targets for the treatment of cervical cancer.