bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of neurobehavioral screening following diagnosis of pediatric cancer
Authors: Pejnovic Laura P. , De Luca Cinzia R. , Gentle Ellen , Anson Katie , Ashley David M. , Anderson Vicki A. , McCarthy Maria C. 
Published: January 2012

AbstractBackgroundNeurobehavioral deficits will affect up to 50% of pediatric cancer survivors treated with central nervous system (CNS)‐directed therapies. Guidelines suggest assessment of neurobehavioral skills at diagnosis be extended from patients with brain tumors to include all patients requiring CNS‐directed therapies. However, comprehensive neuropsychological assessment at diagnosis is difficult to implement and resource intensive. A screening assessment targeted at the neurobehavioral domains known to be impacted by cancer treatments may be more feasible. This study aimed to assess the feasibility of implementing baseline neurobehavioral screening following childhood cancer diagnosis.ProcedureA consecutive sample of 59 recently diagnosed patients requiring CNS‐directed therapies, and 49 healthy controls were assessed using a targeted neurobehavioral screen, which included measures of developmental, cognitive, academic, behavioral, and psychosocial functioning. Feasibility was assessed using a formal feasibility framework, with criteria of brevity, simplicity, relevance, acceptability, and value. Neurobehavioral assessment was compared to standard care to determine the quality of information acquired from the screen.ResultsMean time from diagnosis to assessment was 5.17 weeks. Assessments were completed within 1 hour for 87% of patients. Participant and researcher evaluation indicated the screen was acceptable across a range of criteria, with no differences between clinical and control groups. Compared to standard medical record documentation, the screen provided significant additional information on developmental and neurobehavioral status of patients at diagnosis.ConclusionA brief neurobehavioral screen in the early period following cancer diagnosis is feasible and provides valuable baseline data for children at risk of neurobehavioral late‐effects of cancer treatments. Pediatr Blood Cancer 2012;59:295–300. © 2012 Wiley Periodicals, Inc.
18F‐FDG microPET imaging detects early transient response to an IGF1R inhibitor in genetically engineered rhabdomyosarcoma models
Authors: Soundararajan Anuradha , Abraham Jinu , Nelon Laura D. , Prajapati Suresh I. , Zarzabal Lee Ann , Michalek Joel E. , McHardy Stanton F. , Hawkins Douglas S. , Malempati Suman , Keller Charles 
Published: January 2012

AbstractBackgroundAlveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS) are among the most common and most treatment resistant soft tissue sarcomas of childhood. Here, we evaluated the potential of 18F‐Fluorodeoxyglucose (FDG) as a marker of therapeutic response to picropodophyllin (PPP), an IGF1R inhibitor, in a conditional mouse model of ARMS and a conditional model of ERMS/undifferentiated pleomorphic sarcoma (UPS).ProcedurePrimary tumor cell cultures from Myf6Cre,Pax3:Fkhr,p53 and Pax7CreER,Ptch1,p53 conditional models of ARMS and ERMS/UPS were found to be highly sensitive to PPP (IC50 values 150 and 200 nM, respectively). Animals of each model were then treated with 80 mg/kg/day PPP by intraperitoneal injection for 12 days and imaged by 18F‐FDG microPET.ResultsTumor volumes on day 4 for PPP‐treated ARMS and ERMS mice were lower than untreated control mouse tumor volumes, although treated tumors were larger than day 0. However, tumor FDG uptake was significantly reduced on day 4 for PPP‐treated mice compared to pretreatment baseline or untreated control mice on day 4 (P < 0.05). Nevertheless, by day 12 tumor volumes and FDG uptake for treated mice had increased significantly, indicating rapidly evolving resistance to therapy.Conclusions18F‐FDG PET imaging is a potential imaging biomarker of molecular susceptibility to targeted agents early in treatment for this aggressive form of sarcoma, but may find best use serially for Phase I/II studies where chemotherapy and targeted agents are combined to cytoreduce tumors and abrogate Igf1r inhibitor resistance. Pediatr Blood Cancer 2012;59:485–492. © 2012 Wiley Periodicals, Inc.
Economic assessment of screening for pre‐eclampsia
Authors: Shmueli Amir , Meiri Hamutal , Gonen Ron 
Published: January 2012

ABSTRACTBackgroundPre‐eclampsia is a major contributor to maternal and neonatal morbidity and mortality. Our objectives in this study are to economically assess, from the payer perspective, routine screening for pre‐eclampsia using placental markers ‐placental protein 13 and placental growth factor ‐ and uterine artery Doppler compared with standard care.MethodsA decision model was developed, which progresses through three sequential endpoints, and compares screening with no screening: (1) Pre‐eclampsia yes/no: calculation of the incremental cost of pre‐eclampsia‐case averted; (2) Hospital discharge: calculation of the mean accumulated costs until discharge after delivery; and (3) Offspring death: calculation of the incremental cost per quality of life‐adjusted life‐year gained by screening. Data used includes: (1) Obstetrical data of 14 500 births; (2) cost data from the Israeli Ministry of Health and the literature; and (3) screening performance and outcome from the literature.Results(1) The incremental cost of pre‐eclampsia‐case averted is $66 949 and $24 723 when the prevalence is 1.7 and 5% respectively. (2) With test cost of $112, the total cost until discharge with/without screening is equal. With pre‐eclampsia prevalence of 3%, screening is cheaper. (3) The cost per quality of life‐adjusted life‐year with screening is $18 919 and < $10 000 with pre‐eclampsia prevalence of 1.7 and 3%, respectively.ConclusionsScreening for pre‐eclampsia is cost‐effective under various scenarios. © 2012 John Wiley & Sons, Ltd.
Trying to make sense of the chaos: Clinical psychologists' experiences and perceptions of clients with ‘borderline personality disorder’
Authors: Millar Humera , Gillanders David , Saleem Jannat 
Published: January 2012

ABSTRACTBackgroundEvidence of negative perceptions of clients with ‘borderline personality disorder’ (BPD) in mental health professionals has been well documented. However, few researchers have focused upon perspectives of clinical psychologists on this client group. The aim of the present research was to explore clinical psychologists' experiences and perceptions of clients with BPD.MethodSixteen female clinical psychologists (including trainees and qualified staff) participated in focus groups, 12 of whom had direct clinical experience with this client group. All four groups' audio recordings were transcribed verbatim and analysed using interpretative phenomenological analysis (Smith, 1996).ResultsThe following eight superordinate themes emerged from the analysis: ‘negative perceptions of the client’, ‘undesirable feelings in the psychologist’, ‘positive perceptions of the client’, ‘desirable feelings in the psychologist’, ‘awareness of negativity’, ‘trying to make sense of the chaos’, ‘working in contrast to the system’ and ‘improving our role’.DiscussionImplications include concerns regarding negativity, yet also the suggestion of hope and optimism in working with this client group. Copyright © 2012 John Wiley & Sons, Ltd.
Three‐dimensional SLAM for mapping planetary work site environments
Authors: Tong Chi Hay , Barfoot Timothy D. , Dupuis Érick 
Published: January 2012

AbstractIn this paper, we present a robust framework suitable for conducting three‐dimensional simultaneous localization and mapping (3D SLAM) in a planetary work site environment. Operation in a planetary environment imposes sensing restrictions, as well as challenges due to the rugged terrain. Utilizing a laser rangefinder mounted on a rover platform, we have demonstrated an approach that is able to create globally consistent maps of natural, unstructured 3D terrain. The framework presented in this paper utilizes a sparse‐feature‐based approach and conducts data association using a combination of feature constellations and dense data. Because of feature scarcity, odometry measurements are also incorporated to provide additional information in feature‐poor regions. To maintain global consistency, these measurements are resolved using a batch alignment algorithm, which is reinforced with heterogeneous outlier rejection to improve its robustness to outliers in either measurement type (i.e., laser or odometry). Finally, a map is created from the alignment estimates and the dense data. Extensive validation of the framework is provided using data gathered at two different planetary analogue facilities, which consist of 50 and 102 3D scans, respectively. At these sites, root‐mean‐squared mapping errors of 4.3 and 8.9 cm were achieved. Relative metrics are utilized for localization accuracy and map quality, which facilitate detailed analysis of the performance, including failure modes and possible future improvements. © 2012 Wiley Periodicals, Inc.
MULTISPECIES FISH PASSAGE BEHAVIOUR IN A VERTICAL SLOT FISHWAY ON THE RICHELIEU RIVER, QUEBEC, CANADA
Authors: Thiem J. D. , Binder T. R. , Dumont P. , Hatin D. , Hatry C. , Katopodis C. , Stamplecoskie K. M. , Cooke S. J. 
Published: January 2012

ABSTRACTA shift from target species to ecosystem restoration has generated interest in developing fishways that are capable of passing entire fish communities. Although a number of multispecies fishways now exist in North America, evaluations of these fishways are lacking. We used a passive integrated transponder antenna array to quantify passage success and passage duration of fish using a vertical slot fishway (85 m in length, 2.65 m elevation rise, 12 regular pools and 2 turning basins) at a low head dam on the Richelieu River in Quebec, Canada. Fourteen of the 18 tagged species re‐ascended the fishway, and passage efficiency was highly variable among species (range 25%–100%); however, it was >50% for five of the species well represented in this study (n > 10) (Atlantic salmon, channel catfish, smallmouth bass, walleye and white sucker). Passage duration was likewise highly variable both among and within species (e.g. 1.0–452.9 h for smallmouth bass, 2.4–237.5 h for shorthead redhorse). Although this fishway design was not uniformly successful in passing fish of all species, this study does reveal the species that have problems with ascent and provides an estimate on the time spent in the fishway that is an important component of passage delay. Such information could be used to inform future design refinements to facilitate passage of the entire assemblage with minimal delay. Copyright © 2012 John Wiley & Sons, Ltd.
CARBON FROM PERIPHYTON SUPPORTS FISH BIOMASS IN WATERHOLES OF A WET–DRY TROPICAL RIVER
Authors: Jardine T. D. , Hunt R. J. , Faggotter S. J. , Valdez D. , Burford M. A. , Bunn S. E. 
Published: January 2012

ABSTRACTThe identification of the dominant sources of carbon supporting consumer biomass in aquatic food webs is often difficult but essential to understanding the limits to aquatic secondary production. Stable isotope analysis (SIA) is a powerful tool to estimate the contribution of different sources to consumers, but most food web studies using this approach limit analyses to a few key consumer taxa rather than measuring biomass‐weighted contribution of sources to the entire community. Here we combined stable isotope analysis with standardized measurements of abundance and biomass of fishes and invertebrates in seven waterholes of a wet–dry tropical river sampled early and late in the dry season. We showed that periphyton (as opposed to phytoplankton and terrestrial C3 plant detritus) was responsible for most standing fish biomass (range 42%–97%), whereas benthic invertebrates were reliant on a mixture of the three sources (range 26%–100%). Furthermore, larger, older fishes at high trophic levels (catfish Neoarius spp., sleepy cod Oxyeleotris lineaolatus and barramundi Lates calcarifer) were supported almost exclusively by periphyton. Phytoplankton and detritus supported a considerable biomass of benthic and pelagic invertebrates, but only in taxa that occupied low trophic levels (e.g. snails). These measurements provide further evidence that although periphyton is relatively inconspicuous relative to other sources, it contributes disproportionately to metazoan biomass in wet–dry tropical rivers. Copyright © 2012 John Wiley & Sons, Ltd.
Influence of a wind turbine service life on the mechanical properties of the material and the blade
Authors: Sayer Florian , Bürkner Falko , Buchholz Benjamin , Strobel Michael , van Wingerde Arno M. , Busmann Hans‐Gerd , Seifert Henry 
Published: January 2012

ABSTRACTThis paper presents results out of investigations of the DEBRA‐25 wind turbine blades. Almost unique in the history of modern wind energy, these blades were in operation for 18 years next to a weather station and were investigated afterward. Therefore, the loads experienced in the operational life could be post‐processed accurately with the measured data of the weather station and the turbine. The blades are made of materials that are similar with today's wind turbines. Furthermore, intensive laboratory tests and free field tests have been carried out, and all load assumptions and data and results are still available today. The results include experimental investigations on the moisture content of the load‐carrying material, static and fatigue behavior of the material, the relaxation of the coupling joints, the natural frequencies of the blade and a full scale static blade test. It is shown that the structural performance of the DEBRA‐25 service blades is comparable with modern wind turbine blades. Although some damage was found by visual inspection, the service blade of the DEBRA‐25 showed excellent mechanical behavior in the full scale blade test. Only small changes of the edgewise eigenfrequencies were detected. The pre‐tensioning forces of the IKEA bolts, where the two blade parts are connected, were measured and were still adequate. Copyright © 2012 John Wiley & Sons, Ltd.
Melanopsin, the photopigment of intrinsically photosensitive retinal ganglion cells
Authors: Provencio Ignacio , Warthen Daniel M. 
Published: January 2012

AbstractMelanopsin (gene symbol: Opn4) is the G protein‐coupled photopigment that confers photosensitivity upon intrinsically photosensitive retinal ganglion cells (ipRGCs). ipRGCs are the third class of retinal photoreceptor in mammals, complementing the two previously identified classes, the rods and cones. This novel class, however, differs from rods and cones in many significant ways. First, ipRGCs are more similar morphologically to other retinal ganglion cell classes than to other retinal photoreceptors, i.e., rods and cones. Instead of having photopigment concentrated in a specialized light‐absorbing cellular domain such as the outer segment, ipRGCs have photopigment distributed throughout the plasma membrane of the cell. Second, the phototransduction cascade of ipRGCs more closely resembles that of the rhabdomeric photoreceptors that are typically found in the invertebrates rather than that of ciliary photoreceptors typical of vertebrate visual systems. Accordingly, like the rhabdomeric photoreceptors of invertebrates, ipRGCs depolarize in response to illumination while rods and cones hyperpolarize. Third, in addition to their inherent light sensitivity, ipRGCs also function as a conduit for information that originates in the rods and cones and is conveyed to the brain for the purposes of generating non‐visual light responses. WIREs Membr Transp Signal 2012, 1:228–237. doi: 10.1002/wmts.29For further resources related to this article, please visit the WIREs website.
IP3 receptor‐binding partners in cell‐death mechanisms
Authors: Kiviluoto Santeri , Akl Haidar , Vervliet Tim , Bultynck Geert , Parys Jan B. , Missiaen Ludwig , De Smedt Humbert 
Published: January 2012

AbstractA multiprotein complex, which involves the inositol 1,4,5‐trisphosphate receptor (IP3R) on the endoplasmic reticulum (ER) and the voltage‐dependent anion channel (VDAC) on the outer mitochondrial membrane (OMM) along with multiple other IP3R‐binding partners, is responsible for a privileged and tightly controlled transfer of Ca2+ from the ER to the mitochondria. To stimulate cell metabolism and survival, the mitochondrial Ca2+ level [Ca2+]mit has to be kept within a small physiological range. Decreased or increased Ca2+ fluxes result in an adaptive cellular response involving, respectively, autophagy to meet cellular energy demands or mitophagy to remove damaged mitochondria. Failure of these autophagic responses eventually leads to initiation of cell death. Malfunction of the interaction between the IP3R and its binding partners may have pathological consequences. In cancer cells, such malfunctions lead to an inability to generate large proapoptotic mitochondrial Ca2+ signals. In familial Alzheimer's disease (FAD) and Huntington's disease (HD) on the other hand, exaggerated Ca2+ signals may result in neuronal damage and cell death. WIREs Membr Transp Signal 2012, 1:201–210. doi: 10.1002/wmts.5For further resources related to this article, please visit the WIREs website.
Bias in the Reporting of Family History: Implications for Clinical Care
Authors: Ozanne Elissa M. , O'Connell Adrienne , Bouzan Colleen , Bosinoff Phil , Rourke Taryn , Dowd Dana , Drohan Brian , Millham Fred , Griffin Pat , Halpern Elkan F. , Semine Alan , Hughes Kevin S. 
Published: January 2012

AbstractFamily history of cancer is critical for identifying and managing patients at risk for cancer. However, the quality of family history data is dependent on the accuracy of patient self reporting. Therefore, the validity of family history reporting is crucial to the quality of clinical care. A retrospective review of family history data collected at a community hospital between 2005 and 2009 was performed in 43,257 women presenting for screening mammography. Reported numbers of breast, colon, prostate, lung, and ovarian cancer were compared in maternal relatives vs. paternal relatives and in first vs. second degree relatives. Significant reporting differences were found between maternal and paternal family history of cancer, in addition to degree of relative. The number of paternal family histories of cancer was significantly lower than that of maternal family histories of cancer. Similarly, the percentage of grandparents’ family histories of cancer was significantly lower than the percentage of parents’ family histories of cancer. This trend was found in all cancers except prostate cancer. Self‐reported family history in the community setting is often influenced by both bloodline of the cancer history and the degree of relative affected. This is evident by the underreporting of paternal family histories of cancer, and also, though to a lesser extent, by degree. These discrepancies in reporting family history of cancer imply we need to take more care in collecting accurate family histories and also in the clinical management of individuals in relation to hereditary risk.
Environmentally Friendly Nonionic Surfactants Derived from Tannic Acid: Synthesis, Characterization and Surface Activity
Authors: Negm Nabel A. , El Farargy Ahmed F. M. , Mohammed Dalia Emam , Mohamad Haytham N. 
Published: January 2012

AbstractIn order to discover new and safe surfactants with regard to the environment, new environmentally friendly nonionic surface active agents were synthesized by the reaction of tannic acid (as a natural product presents in several plants) and polyethylene glycol fatty acids containing different numbers of ethylene glycol units. The fatty acids were dodecanoic, hexadecanoic, octadecanoic and oleic acids. The chemical structures of the synthesized surfactants were confirmed using elemental analysis, infrared and 1H‐NMR spectroscopy. The molecular weights of the synthesized surfactants were determined using viscosity measurements and gel permeation chromatography. The surface properties of these surfactants were determined using surface tension measurements. The chemical structure–surface activity relationship of these surfactants showed a strong dependence of the surface activity on their chemical structures including the hydrophobic chains and the number of ethylene glycol units incorporated in the molecules. The free energy of micellization of the surfactants in their solutions showed their tendency towards micellization in the bulk of their solutions, while the free energy of adsorption showed their high tendency towards adsorption at the air–water interface.
Maintenance of Arachidonic Acid and Evidence of Δ5 Desaturation in Cats Fed γ‐Linolenic and Linoleic Acid Enriched Diets
Authors: Trevizan Luciano , de Mello Kessler Alexandre , Brenna J. Thomas , Lawrence Peter , Waldron Mark K. , Bauer John E. 
Published: January 2012

AbstractCats have limited Δ6 desaturase activity. However, γ‐linolenate (GLA) feeding may by‐pass the Δ6 desaturase step allowing arachidonate (ARA) accumulation via Δ5‐desaturation. Alternatively, high dietary linoleate (LNA) may induce limited Δ6 desaturase also resulting in ARA accumulation. Fatty acid profiles were determined after feeding high LNA, high GLA, or adequate LNA diets. Adult female cats (n = 29) were assigned to one of three groups and fed for 8 weeks. Plasma samples were collected at weeks 0, 2, 4 and 8 for plasma triacylglycerol (TAG), total cholesterol (TC), lipoprotein (LP), and plasma and red blood cell membrane phospholipid fatty acid determinations. Time, but no diet, effects were observed for TAG, TC, and LP fractions at weeks 2 and 4 with significant increases likely due to increased dietary fat. However, all values were within feline normal limits. The GLA diet resulted in increased dihomo‐γ‐linolenic acid (DGLA) and ARA as early as week 2, supporting a ∆5 desaturase. Further evidence of Δ5 desaturase was found at high dietary LNA with the appearance of a novel fatty acid, 20:3 ∆7, 11, 14, apparently formed via ∆5 desaturation and chain elongation of LNA. However, Δ6 desaturase induction at high dietary LNA concentration was not observed. Cats are able to maintain plasma and red blood cell ARA when fed a practical diet containing GLA using what appears to be an active Δ5 desaturase enzyme.
Purification of l‐α‐Glycerylphosphorylcholine from the Enzyme Reaction Solutions by Resin Column Chromatography
Authors: Zhang Kangyi , Wang Xingguo , Liu Yuanfa 
Published: January 2012

AbstractColorless l‐α‐glycerylphosphorylcholine (l‐α‐GPC) was obtained at 98.8% purity, and with a specific rotation of −2.5° via a four‐step procedure. l‐α‐GPC was first produced by phospholipase A1 hydrolysis of phosphatidylcholine in an aqueous medium. Almost all the impurities were then removed using two successive D001 cation and D301‐111 anion exchange resin column chromatography procedures, followed by decoloration with active carbon to remove minor pigments and remaining impurities. D001 resin and D301‐111 resin showed remarkable ability for l‐α‐GPC isolation after being used eight times. Thus, this study presents a simple and cost‐effective method for preparing l‐α‐GPC with high purity, low costs, and environmental friendliness, and encourages future investigation into its adaptation for industrial applications.