bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synergistic Electrocatalysis and Spatial Nanoconfinement to Accelerate Sulfur Conversion Kinetics in Aqueous Zn−S Battery
Authors: Li Jun , Liu Jinlong , Xie Fangxi , Bi Ran , Zhang Lei 
Published: June 2024

AbstractAqueous zinc batteries based on the conversion‐type sulfur cathodes are promising in energy storage system due to the high theoretical energy density, low cost, and good safety. However, the multi‐electron solid‐state intermediate conversion reaction of sulfur cathodes generally possess sluggish kinetics, which leads to lower discharge voltage and inefficient sulfur utilization, thus suppressing the practical energy density. Herein, sulfur nanoparticles derived from metal–organic frameworks confined in situ within electrospun fibers derived sulfur and nitrogen co‐doped carbon nanofibers (S@S,N−CNF) composite, which possesses yolk–shell S@C nanostructure, is fabricated through successive sulfidation, pyrolysis, and sulfide oxidation processes, and served as a high‐performance cathode material for Zn−S battery. The S and N dopants on carbon can collectively catalyse sulfur reduction reaction (SRR) by lowering energy barrier and accelerating kinetics to increase discharge voltage and specific capacity. Meanwhile, the yolk–shell S@C structure with spatially confined S nanoparticle yolks is beneficial to improve charge transfer and lower activation energy, thus further expediting SRR kinetics. Furthermore, extensive density functional theory (DFT) calculations reveal that S and N dual‐doping can thermodynamically and dynamically reduce the energy barrier of rate‐determining step (i.e., the transformation of *ZnS4 into *ZnS2) for the overall SRR, thereby significantly accelerating SRR kinetics.
Synthesis of 2‐phenylnaphthalenoid amide derivatives and their topoisomerase IIα inhibitory and antiproliferative activities
Authors: Wu Xiaoxia , Xu Guangsen , Lu Chunhua , Shen Yuemao 
Published: June 2024

AbstractTopoisomerases are highly associated with cell proliferation, becoming an important target for the development of antitumor drugs. 2‐Phenylnaphthalenoids (2PNs) have been identified as human DNA topoisomerase IIα (TopoIIα) inhibitors. In this study, based on the 2PN scaffold, 20 amide derivatives (J1–J10, K1–K10) were synthesized. Among them, K10 showed high TopoIIα inhibitory activity and stronger antiproliferation activity against HepG‐2 and MDA‐MB‐231 cells (IC50 0.33 and 0.63 μM, respectively) than the positive control VP‐16 (IC50 9.19 and 10.86 μM) and the lead F2 (IC50 0.64 and 1.51 μM). Meanwhile, K10 could also inhibit migration and promote apoptosis of HepG‐2 and MDA‐MB‐231 cells. Therefore, K10 can be developed into a potent TopoIIα inhibitor as an antitumor agent. The structure–activity relationship was also discussed.
3‐Methylpyridine: Synthesis and Applications
Authors: Yin Zihang , Cao Yanwei , Sun Wen , Chen Gang , Fang Xianjie , He Lin 
Published: June 2024

Abstract3‐Methylpyridine holds a pivotal role in organic chemistry as it constitutes a fundamental structure in numerous biologically active compounds. Its significance is underscored by its involvement in synthesizing vitamin B3 and developing pyridine insecticides, garnering considerable attention. Consequently, chemists have dedicated efforts to devising efficient and environmentally friendly methods for its preparation. This review systematically reviews several synthetic routes to 3‐methylpyridine, alongside recent advancements, while summarizing its application progress in various organic transformations.
Utilization of deep eutectic solvents in the production of high‐value compounds from biomass
Authors: Monroy Andrés F. , Caicedo Gerardo A. , Martínez José J. , Romanelli Gustavo P. 
Published: June 2024

AbstractThis review examines the role of deep eutectic solvents (DESs) in the biorefinery process. It covers the characteristics and classification of two‐component DESs, their preparation methods, and their physicochemical properties. The various applications of DES systems in biomass pretreatment, including lignin and hemicellulose removal, production of cellulose nanofibers, and the extraction of proteins, lipids, and phenolic compounds, among others, are explored. The synthesis of platform molecules using DES is also discussed. Finally, this review provides some tools that may be useful for researching the involvement of DES systems in high‐ or low‐biomass biorefineries.
Recent advances in photoresponsive printing inks for security encoding applications
Authors: Abdelrahman Meram S. , Khattab Tawfik A. 
Published: June 2024

AbstractCounterfeiting of banknotes, important documents, and branded goods continues to be a major worldwide problem for governments, businesses, and consumers. This problem has serious financial, security, and health implications. Due to their stability for printing on various substrates, the photochromic anticounterfeiting inks have received important interest. There have been various photochromic agents, such as polymer nanoparticles, quantum and carbon dots, and organic and inorganic fluorophores and luminophores, which have been broadly used for antiforging applications. In comparison to organic agents, inorganic photochromic materials have better stability under reversible/long‐term light illumination. Recently, the remarkable optical characteristics and chemical stability of photoluminescent and photochromic agents have led to their extensive usage anticounterfeiting products. There have been also several strategies to tackle the rising problem of counterfeiting. Both of solvent‐based and water‐based inks have been developed for security encoding purposes. Additionally, the printing methods, including screen printing, labeling, stamping, inkjet printing, and handwriting, that have been used to apply anticounterfeiting inks onto various surfaces are discussed. The limitations of photoluminescent and photochromic agents and the potential for their future preparation to combat counterfeiting were discussed. This review would benefit academic researchers and industrial developers who are interested in the area of security printing.
Sustainability in design: Sustainable fashion design practices and environmental impact using mixed‐method analysis
Authors: Ma Juan , Huang Lijun , Guo Qi , Zhu Yilin 
Published: June 2024

AbstractSustainable fashion design arises as a crucial reaction to the industry's fashion necessity for environmental influence reduction and addressing sustainability challenges effectively. This study examines the nuanced dimensions of this pursuit and its influence on the industry's environmental performance. Through a mixed‐method research approach involving 268 designers and 159 participants included in the interview process (fashion experts, entrepreneurs, and business strategists), the investigation explored the efficacy of eco‐friendly practices in enhancing overall sustainability. The findings underscore significant improvements in environmental performance metrics for fashion companies embracing sustainable design practices, revealing a direct correlation between such practices and a reduction in carbon footprint. The study identifies key drivers prompting fashion businesses to invest in innovative sustainable design solutions, particularly in response to sustainability challenges and consumer demand for eco‐friendly products. Collaboration with eco‐conscious suppliers and transparent supply chain practices is pivotal for effectively addressing sustainability challenges. Besides, the research underscores the significance of incorporating principles of circular economy, including recycling and upcycling, to augment environmental performance within the fashion sector. By offering practical insights and theoretical reflections, our research enriches the discourse on sustainable fashion (SF), guiding industry stakeholders, policymakers, and researchers aiming for a sustainable and ethical future.
A retrospective study of first‐line therapy and subsequent pyrotinib treatment in advanced lung adenocarcinoma with HER2 mutations
Authors: Wang Li , Wu Yueran , Ren Zhixuan , Chu Xiangling , Chen Jianing , Liu Li , Zhao Jing , Yu Xin , Xie Mengqing , Su Chunxia 
Published: June 2024

AbstractObjectivesHER2 is an infrequently mutated driver gene in non‐small cell lung cancer (NSCLC). At present, there has been no comprehensive large‐scale clinical study to establish the optimal first‐line treatment strategy for advanced lung adenocarcinoma (LUAD) with HER2‐Mutant. Besides that, the effectiveness and safety of pyrotinib, a pan‐HER inhibitor, in the context of NSCLC are still undergoing investigation.Materials and MethodsIn this study, we conducted a retrospective data collection of HER2‐Mutated advanced LUAD who received first‐line treatment and pyrotinib between May 2014 and June 2023. Patients treated with chemotherapy, chemotherapy + immune checkpoint inhibitors (ICIs), chemotherapy + bevacizumab and pyrotinib in first‐line treatment. Furthermore, we collected data on the efficacy and safety of pyrotinib in these patients after disease progression. The main endpoint of the study was progression‐free survival (PFS).ResultsIn the final analysis, 89 patients were included in the first‐line cohort and 30 patients were included in the pyrotinib cohort. In the first‐line treatment cohort, chemotherapy + ICIs, chemotherapy + bevacizumab, and pyrotinib exhibited notable survival benefits compared to chemotherapy (median PFS: 9.87 vs. 7.77 vs. 7.10 vs. 5.40 months, p‐value < 0.05). Furthermore, patients with a first‐line treatment PFS of less than 6 months may potentially benefit from subsequent treatment with pyrotinib (median PFS: 7.467 vs. 3.000, p‐value = 0.0490).ConclusionsIn the first‐line treatment of HER2‐Mutant LUAD, regimens involving combinations like chemotherapy + ICIs, chemotherapy + bevacizumab, and pyrotinib may confer enhanced survival advantages compared to chemotherapy. Nevertheless, no significant distinctions were observed among these three treatment strategies, underscoring the imperative to identify biomarkers for the discerning selection of suitable therapeutic modalities. Moreover, patients with suboptimal response to first‐line treatment may potentially derive more benefit from pyrotinib.
CRAFITY score benefits hepatocellular carcinoma patients treated with transarterial chemoembolization and lenvatinib
Authors: Zhang Lin , Yang Hongcai , Ning Shangkun , Wu Zhijuan , Wang Dianzhe , Liang Hexin , Wang Chunni , Chang Xu 
Published: June 2024

AbstractBackgroundThe CRAFITY score serves as a simple and effective predictive model for individuals diagnosed with hepatocellular carcinoma (HCC) and subjected to treatment with atezolizumab and bevacizumab (Atez/Bev). However, no large sample size studies have reported the application of the CRAFITY score among HCC patients undergoing transarterial chemoembolization (TACE) in conjunction with lenvatinib. This research aims to assess the prognostic role of the CRAFITY score in the context of individuals with HCC receiving TACE in combination with lenvatinib.MethodsThis retrospective analysis encompassed 314 individuals diagnosed with HCC who underwent the combination of TACE and lenvatinib at two medical facilities in China from August 2019 to August 2022 (comprising a training cohort of n = 172 and a validation cohort of n = 142). We investigated the prognostic values of overall survival (OS), progression‐free survival (PFS), disease control rate, and objective response rate in the training cohort based on the CRAFITY scores. Furthermore, the predictive capacity of the model was corroborated through validation using an external cohort.ResultsWe included 174 and 142 patients treated with TACE plus lenvatinib in the training and validation cohorts, correspondingly. PFS and OS differed across all three groups in all training and validation cohorts, based on the CRAFITY score (p < 0.001). In both cohorts, the CRAFITY score effectively predicted tumor response (p < 0.001). Moreover, among the 121 patients who received TACE, lenvatinib, and immunotherapy, the CRAFITY score showed promising predictive efficacy in PFS and OS.ConclusionsThe CRAFITY score, utilizing C‐reactive protein and alpha‐fetoprotein values, emerges as a dependable and pragmatic instrument for forecasting the effectiveness of TACE plus lenvatinib in individuals with unresectable HCC. This scoring system holds the potential to assist oncologists in making informed clinical decisions.
Chemoproteomic Strategy Identifies PfUCHL3 as the Target of Halofuginone
Authors: Yu Si‐Miao , Zhao Mei‐Mei , Zheng Yong‐Zhe , Zhang Ji‐Chao , Liu Zheng‐Ping , Tu Peng‐Fei , Wang Heng , Wei Chun‐Yan , Zeng Ke‐Wu 
Published: June 2024

AbstractThe human malaria parasite Plasmodium falciparum (P. falciparum) continues to pose a significant public health challenge, leading to millions of fatalities globally. Halofuginone (HF) has shown a significant anti‐P. falciparum effect, suggesting its potential as a therapeutic agent for malaria treatment. In this study, we synthesized a photoaffinity labeling probe of HF to identify its direct target in P. falciparum. Our results reveal that ubiquitin carboxyl‐terminal hydrolase 3 (PfUCHL3) acts as a crucial target protein of HF, which modulates parasite growth in the intraerythrocytic cycle. In particular, we discovered that HF potentially forms hydrogen bonds with the Leu10, Glu11, and Arg217 sites of PfUCHL3, thereby inducing an allosteric effect by promoting the embedding of the helix 6’ region on the protein surface. Furthermore, HF disrupts the expression of multiple functional proteins mediated by PfUCHL3, specifically those that play crucial roles in amino acid biosynthesis and metabolism in P. falciparum. Taken together, this study highlights PfUCHL3 as a previously undisclosed druggable target of HF, which contributes to the development of novel anti‐malarial agents in the future.
Construction of Smartphone‐Integrated Nanozyme Sensor Based on Amino Acid‐Modulated Gold Nanoparticles
Authors: Wu Congnan , Li Qing , Su Rongxin , Wang Yuefei , Qi Wei 
Published: June 2024

AbstractAmino acids are not only the building blocks of proteins but also lead to the development of novel nanomaterials with unique properties. Herein, we proposed a simple strategy to produce gold nanoparticles (Au NPs) with peroxidase‐like (POD‐like) activities by using a series of amino acids as reducing agents, named Au NPs@M (M represents different amino acids). The Au NPs@His was identified as the nanozyme with the most potent catalytic performance, which was used in combination with smartphones to achieve rapid detection of hydrogen peroxide with a detection limit of 0.966 μM. It also enables rapid detection of glucose with a detection limit of 2.904 μM, highlighting the significant contribution of Au NPs@His in expediting the detection of critical biomolecules. This work not only provides a convenient and highly efficient method to identify glucose but also shows the potential of histidine as a reducing agent in constructing Au nanomaterials exerting enzyme‐like catalysis.
Comprehensive analysis of the prognostic value of glutathione S‐transferases Mu family members in breast cancer
Authors: Gohari Nazanin , Abbasi Elham , Akrami Hassan 
Published: June 2024

AbstractBreast cancer (BC) remains a significant public health concern globally, with a high number of reported cases and a substantial number of deaths every year. Accumulating reactive oxygen species (ROS) and oxidative stress are related to BC and the Glutathione S‐transferases Mu (GSTM) family is one of the most important enzymatic detoxifiers associated with many cancers. In this study, UALCAN, Kaplan‐Meier plotter, bc‐GenExMiner, cBioPortal, STRING, Enrichr, and TIMER databases were employed to carry out a comprehensive bioinformatic analysis and provide new insight into the prognostic value of GSTMs in BC. GSTM2‐5 genes in mRNA and protein levels were found to be expressed at lower levels in breast tumors compared to normal tissues, and reduction in mRNA levels is linked to shorter overall survival (OS) and relapse‐free survival (RFS). The lower mRNA levels of GSTMs were strongly associated with the worse Scarff‐Bloom‐Richardson (SBR) grades (p < 0.0001). The mRNA levels of all five GSTMs were substantially higher in estrogen receptor (ER)‐positive and progesterone receptor (PR)‐positive compared to ER‐negative and PR‐negative BC patients. As well, when nodal status was compared, GSTM1, GSTM3, and GSTM5 were significantly higher in nodal‐positive BC patients (p < .01). Furthermore, GSTM4 had the most gene alteration (4%) among other family members, and GSTM5 showed the strongest correlation with CD4+ T cells (Cor= .234, p = 2.22e‐13). In conclusion, our results suggest that GSTM family members may be helpful as biomarkers for prognosis and as therapeutic targets in BC.
Corelating the molecular structure of BAG3 to its oncogenic role
Authors: Pattoo Tabinda Showkat , Khanday Firdous A. 
Published: June 2024

AbstractBAG3 is a multifaceted protein characterised by having WW domain, PXXP motif and BAG domain. This protein gets upregulated during malignant transformation of cells and has been associated with poorer survival of patients. Procancerous activity of BAG domain of BAG3 is well documented. BAG domain interacts with ATPase domain of Hsp‐70 preventing protein delivery to proteasome. This impediment results in enhanced cell survival, proliferation, resistance to apoptosis and chemoresistance. Besides BAG domain other two domains/motifs of BAG3 are under research vigilance to explore its further oncogenic role. This review summarises the role of different structural determinants of BAG3 in elevating oncogenesis. Based on the already existing findings, more interacting partners of BAG3 are anticipated. The anticipated partners of BAG3 can shed a wealth of information into the mechanistic insights of its proproliferative role. Proper insights into the mechanistic details adopted by BAG3 to curtail/elaborate activity of anticipated interacting partners can serve as a potent target for development of therapeutic interventions.
Botulinum toxin therapy for isolated first dorsal interosseous muscle pain and hypertrophy: A case report
Authors: Rahimibarghani Sarvenaz , Aghaghazvini Leila , Shirzad Niloofar , Fateh Hamid R. 
Published: June 2024

Key Clinical MessageBotulinum toxin (BTX) injection can be an effective treatment for persistent pain and functional impairment associated with hypertrophy of the first dorsal interosseous muscle. It offers a non‐surgical and minimally invasive alternative for those who have failed conservative treatment, showcasing the therapeutic promise of BTX for addressing similar musculoskeletal conditions.
Complete clinical response to chemoradiation in adenoid cystic carcinoma of the base of tongue: Case report of a rare tumor in a rare location
Authors: Bayani Reyhaneh , Hasanzadeh Elyas , Javadirad Etrat , Azarpeikan Ali Reza , Babaei Mohammad , Mousavi Darzikolaee Nima 
Published: June 2024

Key Clinical MessageAdenoid cystic carcinoma (ACC) is an uncommon malignancy of head and neck. Although the cornerstone of treatment is surgery, concurrent chemoradiotherapy (CRT) might be used as an effective treatment for unresectable tumors. Herein we report a case of massive ACC of base of tongue with durable complete response to definitive CRT.AbstractAdenoid cystic carcinoma (ACC) is a rare tumor accounting for 1% of all head and neck cancers. The best treatment option is complete surgical resection with or without adjuvant radiotherapy. When surgical resection is not feasible, definitive radiotherapy with or without concurrent chemotherapy can be considered. Herein we report a non‐smoker 72‐year‐old woman presented with throat discomfort and sensation of a lump. Evaluation revealed an unresectable adenoid cystic carcinoma of the base of tongue in whom complete clinical response was achieved after definitive concurrent chemoradiation. Although the cornerstone of treatment is complete surgical resection, this case report indicates that concurrent chemoradiotherapy might result in complete clinical response and could be used as a definitive treatment in selected ACC tumors.
Postprandial abdominal pain and weight loss as the initial presentation of abdominal neuroendocrine tumor recurrence
Authors: Yingchoncharoen Pitchaporn , Bharathidasan Kavya , Thongpiya Jerapas , Bernal Diego , Abdelnabi Mahmoud 
Published: June 2024

Key Clinical MessageNeuroendocrine tumors, rare and slow‐growing, primarily affect the gastrointestinal tract, causing symptoms due to hormone secretion or mass effect. This case image described postprandial abdominal pain as an atypical initial presentation of abdominal neuroendocrine tumor recurrence in a middle‐aged male.AbstractNeuroendocrine tumors are a group of rare, slow‐growing neoplasms, most commonly affecting the gastrointestinal tract. Clinical presentations include symptoms related to the mass or hypersecretion of hormones, such as flushing, diarrhea, or bronchoconstriction. Postprandial abdominal pain is most commonly related to chronic mesenteric ischemia from atherosclerotic changes but is rarely linked to external mass compression, including gastrointestinal tumors. Hereby, the authors highlight an uncommon presentation of NET, which is very challenging to diagnose and demands a high index of suspicion.
Protein‐Protein Stabilization in VIVO/8‐Hydroxyquinoline–Lysozyme Adducts
Authors: Paolillo Maddalena , Ferraro Giarita , Pisanu Federico , Maréchal Jean‐Didier , Sciortino Giuseppe , Garribba Eugenio , Merlino Antonello 
Published: June 2024

AbstractThe binding of the potential drug [VIVO(8‐HQ)2], where 8‐HQ is 8‐hydroxyquinolinato, with hen egg white lysozyme (HEWL) was evaluated through spectroscopic (electron paramagnetic resonance, EPR, and UV‐visible), spectrometric (electrospray ionization‐mass spectrometry, ESI‐MS), crystallographic (X‐ray diffraction, XRD), and computational (DFT and docking) studies. ESI‐MS indicates the interaction of [VIVO(8‐HQ)(H2O)]+ and [VIVO(8‐HQ)2(H2O)] species with HEWL. Room temperature EPR spectra suggest both covalent and non‐covalent binding of the two different V‐containing fragments. XRD analyses confirm these findings, showing that [VIVO(8‐HQ)(H2O)]+ interacts covalently with the solvent exposed Asp119, while cis‐[VIVO(8‐HQ)2(H2O)] non‐covalently with Arg128 and Lys96 from a symmetry mate. The covalent binding of [VIVO(8‐HQ)(H2O)]+ to Asp119 is favored by a π‐π contact with Trp62 and a H‐bond with Asn103 of a symmetry‐related molecule. Additionally, the covalent binding of VVO2+ to Asp48 and non‐covalent binding of other V‐containing fragments to Arg5, Cys6, and Glu7 are revealed. Molecular docking indicates that, in the absence of the interactions occurring at the protein‐protein interface close to Asp119, the covalent binding to Glu35 or Asp52 should be preferred. Such a protein‐protein stabilization could be more common than what believed up today, at least in the solid state, and should be considered in the characterization of metal‐protein adducts.