bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antihypertensive treatment during pregnancy and functional development at primary school age in a historical cohort study
Authors: Pasker‐de Jong PCM , Zielhuis GA , van Gelder MMHJ , Pellegrino A , Gabreëls FJM , Eskes TKAB 
Published: May 2010

Please cite this paper as: Pasker‐de Jong P, Zielhuis G, van Gelder M, Pellegrino A, Gabreëls F, Eskes T. Antihypertensive treatment during pregnancy and functional development at primary school age in a historical cohort study. BJOG 2010;117:1080–1087.Objective  To determine the functional development of children born after treatment of mild‐to‐moderate gestational hypertension with labetalol versus methyldopa, and no antihypertensive treatment.Design  Historical cohort study.Setting  Twelve Dutch hospital departments of obstetrics.Population  Live‐born children born in these hospitals and prenatally exposed to labetalol, methyldopa, or bed rest because of mild‐to‐moderate gestational hypertension.Methods  Central nervous system development was measured with standard tests at 4–10 years of age. Linear regression techniques and Pearson’s chi‐square tests were used to compare the groups with regard to the outcome measures.Main outcome measures  Intelligence quotient (IQ), concentration, motor development, and behaviour at primary school age.Results  A total of 202 children were included in the analyses. More children exposed to labetalol had attention deficit hyperactivity disorder (ADHD) than those exposed to methyldopa (OR 2.3; 95% CI 0.7–7.3), or those born to women who had been admitted for bed rest (OR 4.1; 95% CI 1.2–13.9). Sleeping problems seemed to be reported more frequently after prenatal methyldopa exposure than after exposure to labetalol (OR 3.2; 95% CI 0.6–16.7) or bed rest (OR 4.5; 95% CI 0.9–23.2), although the differences were not statistically significant. Test scores on other aspects of functional development did not differ between the three groups.Conclusions  In this hypothesis‐generating study, labetalol exposure in utero seemed to increase the risk of ADHD among children of primary school age, whereas prenatal methyldopa exposure might influence sleep. Further studies with appropriate sample sizes are warranted to determine the long‐term effects of antihypertensive medications.
Giving Birth in Two Maternity Hospitals in Lithuania
Authors: Chalmers Beverley , Jeckaite Dalia 
Published: May 2010

Abstract:  Background:  In many hospitals in former Soviet countries, traditional Soviet perinatal policies remain in place, although in others reforms have been introduced. This study explores women’s experiences during labor and birth in two Lithuanian maternity hospitals. The hospitals differed in that one (S) followed traditional Soviet era maternity practices whereas the other (P) had been exposed to World Health Organization‐Euro practices and policies with respect to more up‐to‐date evidence‐based and family‐centered care. Methods:  Consecutive women giving birth in the two maternity hospitals were asked to participate in a survey. Completed responses were obtained from 416 women in one hospital (P) and 304 in the other hospital (S) representing 92.4 and 67.5 percent response rates, respectively.Results:  Rates of interventions in both hospitals were similarly high with, however, P hospital being more likely to be sensitive to women’s psychosocial needs, such as being allowed to eat and drink more often during labor, and to have their husband or partner with them for labor and birth. Conclusion:  It appears that in Lithuania, as in many parts of the world, introducing changes to the clinical care of birth takes time, and psychosocial changes may be easier to introduce than alterations in clinical practice. (BIRTH 37:2 June 2010)
Prevalence, Outcome, and Women’s Experiences of External Cephalic Version in a Low‐Risk Population
Authors: Rijnders Marlies , Offerhaus Pien , Van Dommelen Paula , Wiegers Therese , Buitendijk Simone 
Published: May 2010

Abstract:  Background:  Until recently, external cephalic version to prevent breech presentation at birth was not widely accepted. The objective of our study was to assess the prevalence, outcomes, and women’s experiences of external cephalic version to improve the implementation of the procedure in the Netherlands. Methods:  A prospective cohort study was conducted of 167 women under the care of a midwife with confirmed breech presentation at a gestational age of 33 completed weeks or more. Results:  Between June 2007 and January 2008, 167 women with a confirmed breech presentation were offered an external cephalic version. Of this group, 123 women (73.7%, 95% CI: 65.5–80.5) subsequently received the version. These women had about a ninefold increased probability of a cephalic presentation at birth compared with women who did not undergo a version (relative risk [RR]: 8.8, 95% CI: 2.2–34.8). The chance of a vaginal birth after an external cephalic version was almost threefold (RR: 2.7, 95% CI: 1.5–5.0). The success rate was 39 percent, although considerable differences existed associated with region and parity. Ninety‐four percent of women with a successful version rated it as a good experience compared with 71 percent of women who had a failed version (p = 0.015). Significant pain during the version was experienced by 34 percent of women, of whom 18 percent also experienced fear during the version, compared with no women who reported little or no pain (p = 0.006). Women who reported significant pain or fear during the version experienced the version more negatively (OR: 6.0, 95% CI: 3.3–12.2 and OR: 2.7, 95% CI: 1.1–6.0, respectively).Conclusions:  One in every four women with a breech presentation in independent midwifery care did not receive an external cephalic version. Of the women who received a version one third experienced significant pain during the procedure. Considerable regional variation in success rate existed. (BIRTH 37:2 June 2010)
Media Representations of Pregnancy and Childbirth: An Analysis of Reality Television Programs in the United States
Authors: Morris Theresa , McInerney Katherine 
Published: May 2010

Abstract:  Background:  Reality‐based birth television programs in the United States warrant close analysis because many women watch these shows to learn about birth. The purpose of this study was to understand how reproduction and birth are portrayed in these shows. We hypothesized that women’s bodies are displayed as inferior and in need of surveillance and that this inferiority of the female body is solved through technology and a medical approach to birth. Methods:  We performed a content analysis of 85 reality‐based birth television shows, depicting 123 births, aired in the United States on Discovery Health and The Learning Channel in November 2007. Results:  The study hypotheses were largely supported. Women’s bodies were typically displayed as incapable of birthing a baby without medical intervention. The shows also lacked diversity in the representations of birthing women and, in particular, overrepresented married women and heterosexual women. Conclusions:  This research suggests that reality‐based birth television programs do not give women an accurate portrayal of how women typically experience birth in the United States, nor are the shows consistent with evidence‐based maternity practices. (BIRTH 37:2 June 2010)
Factors Influencing the Infant Feeding Decision for Socioeconomically Deprived Pregnant Teenagers: The Moral Dimension
Authors: Dyson Lisa , Green Josephine M. , Renfrew Mary J. , McMillan Brian , Woolridge Mike 
Published: May 2010

Abstract:  Background:  The importance of breastfeeding‐related health outcomes in reducing inequalities in health has been recognized as a National Health Service target to increase initiation rates especially among disadvantaged groups in England. This study examined the psychosocial factors influencing infant feeding intention among pregnant teenagers expecting their first baby and living in deprived urban areas in England. Methods:  A mixed methods study, using a quantitative questionnaire based on the Theory of Planned Behaviour, was conducted in four English regions with predominantly white and Asian teenagers (n = 71). This method identified which of all known Theory of Planned Behaviour variables were the most important in influencing feeding intentions. Focus groups provided contextual insight into the meaning of these variables for white pregnant teenagers living in a northern English inner city (n = 17). Results:  Moral norms were identified as the most predictive variable influencing teenage intention to formula feed or breastfeed. The likelihood that breastfeeding “will be embarrassing” was the only attitudinal belief rated as significantly important in influencing teenage intention to breastfeed. Three overarching themes emerged from the focus group data: “moral norms,”“sexuality of the breast,” and “self‐esteem,” with concerns relating to breastfeeding in public cutting across all themes.Conclusions:  Breastfeeding was viewed as a morally inappropriate behavior by most of these teenagers, with formula feeding being perceived as the appropriate behavior. Existing breastfeeding promotion activities are likely to continue to fail to reach teenagers experiencing deprivation in England in the absence of effective strategies to change the underlying negative moral norms toward breastfeeding. (BIRTH 37:2 June 2010)
Environmental Assessment of Wood‐Based Biofuel Production and Consumption Scenarios in Norway
Authors: Bright Ryan M. , Strømman Anders Hammer , Hawkins Troy R. 
Published: May 2010

SummaryIn Norway, the boreal forest offers a considerable resource base, and emerging technologies may soon make it commercially viable to convert these resources into low‐carbon biofuels. Decision makers are required to make informed decisions about the environmental implications of wood biofuels today that will affect the medium‐ and long‐term development of a wood‐based biofuels industry in Norway. We first assess the national forest‐derived resource base for use in biofuel production. A set of biomass conversion technologies is then chosen and evaluated for scenarios addressing biofuel production and consumption by select industry sectors. We then apply an environmentally extended, mixed‐unit, two‐region input−output model to quantify the global warming mitigation and fossil fuel displacement potentials of two biofuel production and consumption scenarios in Norway up to 2050. We find that a growing resource base, when used to produce advanced biofuels, results in cumulative global warming mitigation potentials of between 58 and 83 megatonnes of carbon dioxide equivalents avoided (Mt‐CO2‐eq.‐avoided) in Norway, depending on the biofuel scenario. In recent years, however, the domestic pulp and paper industry—due to increasing exposure to international competition, capacity reductions, and increasing production costs—has been in decline. In the face of a declining domestic pulp and paper industry, imported pulp and paper products are required to maintain the demand for these goods and thus the greenhouse gas (GHG) emissions of the exporting region embodied in Norway's pulp and paper imports reduce the systemwide benefit in terms of avoided greenhouse gas emissions by 27%.
Liesegang rings in an apocrine hidrocystoma: a case report and review of literature
Authors: Gilchrist Heidi M. , Wick Mark R. , Patterson James W. 
Published: May 2010

Liesegang rings represent an in vivo chemical precipitation phenomenon representing a potential diagnostic pitfall for misdiagnosis as parasitic infections. These acellular patterns of lamellar concretions are rare in human tissue. The authors report a case of Liesegang rings observed within an intradermal apocrine hidrocystoma and review the literature for reports of these structures, with particular emphasis on mucocutaneous lesions.Gilchrist HM, Wick MR, Patterson JW. Liesegang rings in an apocrine hidrocystoma.
PAX8 discriminates ovarian metastases from adnexal tumors and other cutaneous metastases
Authors: Fujiwara Mika , Taube Janis , Sharma Mima , McCalmont Timothy H. , Kim Jinah 
Published: May 2010

Background: The distinction of metastatic ovarian carcinoma from other metastatic carcinomas and primary adnexal lesions in the skin is often difficult. PAX8 is a transcription factor that plays a critical role in development of the Müllerian system and has been shown to be a useful discriminatory marker between ovarian and breast carcinomas. Identification of ovarian cutaneous metastases may be of benefit in patients with familial breast‐ovarian carcinoma syndrome. Methods: PAX8 immunohistochemical analysis was performed on 24 cases of metastatic adenocarcinomas to the skin and compared with 7 cases of primary adnexal lesions and also compared with p63 immunohistochemical staining results. Patients with metastatic adenocarcinomas had clinically documented primary malignancies, and patients with primary adnexal carcinomas had no known history of another adenocarcinoma. Results: Cutaneous ovarian and renal cell carcinoma metastases (2/2 and 8/8, respectively) showed positive nuclear expression of PAX8. PAX8 immunohistochemical staining in primary adnexal and other cutaneous metastases was completely negative (0/7 and 0/16, respectively). The p63 expression profile supported the distinction between adnexal and metastatic adenocarcinomas. Conclusions: Although cutaneous ovarian metastasis is a rare phenomenon, the prognosis is extremely poor. PAX8 expression is a useful marker that effectively discriminated metastatic ovarian carcinomas from metastatic breast carcinomas and primary adnexal tumors.Fujiwara M, Taube J, Sharma M, McCalmont TH, Kim J. PAX8 discriminates ovarian metastases from adnexal tumors and other cutaneous metastases.
Accounting for Respondent Uncertainty to Improve Willingness‐to‐Pay Estimates
Authors: Moore Rebecca , Bishop Richard C. , Provencher Bill , Champ Patricia A. 
Published: May 2010

In this paper, we develop an econometric model of willingness to pay (WTP) that integrates data on respondent uncertainty regarding their own WTP. The integration is utility consistent, there is no recoding of variables, and no need to calibrate the contingent responses to actual payment data, so the approach can “stand alone.” In an application to a valuation study related to whooping crane restoration, we find that this model generates a statistically lower expected WTP than the standard contingent valuation (CV) model. Moreover, the WTP function estimated with this model is not statistically different from that estimated using actual payment data suggesting that, when properly analyzed using data on respondent uncertainty, CV decisions can simulate actual payment decisions. This method allows for more reliable estimates of WTP that incorporate respondent uncertainty without the need for collecting comparable actual payment data. Dans le présent article, nous avons élaboré un modèle économétrique d’estimation qui internalise l’incertitude des répondants quant à leur propre consentement à payer. L’internalisation est fidèle à la notion «d’utilité»; il n’a pas été nécessaire de transformer les variables ni de calibrer les réponses des répondants avec des paiements réels. L’application de la méthode n’est donc pas dépendante d’autres données ou méthodes. Dans une étude d’évaluation sur le rétablissement de la grue blanche d’Amérique dans laquelle ce modèle a été utilisé, nous avons trouvé que le consentement à payer attendu était statistiquement plus faible que celui obtenu à l’aide de la méthode d’évaluation contingente standard. Par ailleurs, la fonction de consentement à payer estimée à l’aide de ce modèle n’est pas statistiquement différente de celle estimée à l’aide de paiements réels. Cette observation autorise à penser que, lorsque le modèle tient compte des données sur l’incertitude des répondants, les décisions obtenues à l’aide de la méthode d’évaluation contingente peuvent simuler les décisions obtenues à l’aide de paiements réels. Cette méthode permet d’obtenir des estimations du consentement à payer plus fiables, lesquelles intègrent l’incertitude des répondants sans la nécessité de collecter des données comparables de paiements réels.
Oncolytic Adenovirus Coding for Granulocyte Macrophage Colony-Stimulating Factor Induces Antitumoral Immunity in Cancer Patients
Authors: Cerullo Vincenzo , Pesonen Sari , Diaconu Iulia , Escutenaire Sophie , Arstila Petteri T. , Ugolini Matteo , Nokisalmi Petri , Raki Mari , Laasonen Leena , Särkioja Merja , Rajecki Maria , Kangasniemi Lotta , Guse Kilian , Helminen Andreas , Ahtiainen Laura , Ristimäki Ari , Räisänen-Sokolowski Anne , Haavisto Elina , Oksanen Minna , Karli Eerika , Karioja-Kallio Aila , Holm Sirkka-Liisa , Kouri Mauri , Joensuu Timo , Kanerva Anna , Hemminki Akseli 
Published: May 2010

Abstract
Granulocyte macrophage colony-stimulating factor (GMCSF) can mediate antitumor effects by recruiting natural killer cells and by induction of tumor-specific cytotoxic T-cells through antigen-presenting cells. Oncolytic tumor cell–killing can produce a potent costimulatory danger signal and release of tumor epitopes for antigen-presenting cell sampling. Therefore, an oncolytic adenovirus coding for GMCSF was engineered and shown to induce tumor-specific immunity in an immunocompetent syngeneic hamster model. Subsequently, 20 patients with advanced solid tumors refractory to standard therapies were treated with Ad5-D24-GMCSF. Of the 16 radiologically evaluable patients, 2 had complete responses, 1 had a minor response, and 5 had disease stabilization. Responses were frequently seen in injected and noninjected tumors. Treatment was well tolerated and resulted in the induction of both tumor-specific and virus-specific immunity as measured by ELISPOT and pentamer analysis. This is the first time that oncolytic virus–mediated antitumor immunity has been shown in humans. Ad5-D24-GMCSF is promising for further clinical testing. Cancer Res; 70(11); 4297–309. ©2010 AACR.
CD44posCD49fhiCD133/2hi Defines Xenograft-Initiating Cells in Estrogen Receptor–Negative Breast Cancer
Authors: Meyer Matthew J. , Fleming Jodie M. , Lin Amy F. , Hussnain S. Amal , Ginsburg Erika , Vonderhaar Barbara K. 
Published: May 2010

Abstract
Defining the populations of tumor-initating cells that are present in tumors is a first step in developing therapeutics to target these cells. We show here that both CD44posCD24neg and CD44posCD24pos cell populations in estrogen receptor (ER) α–negative breast tumors are tumorigenic in murine xenograft models. We also describe a third population of xenograft-initiating cells (XIC) enriched in CD44posCD49fhiCD133/2hi cells that display heightened tumorigenicity, self-renewal in vivo, and the capacity to give rise to functional and molecular heterogeneity. Consistent with their capacity for self-renewal, these cells express elevated levels of Sox2, Bmi-1, and/or Nanog and their CpG islands are hypermethylated relative to nontumorigenic cells. These differences in methylome regulation may be responsible for the dramatic functional differences between the two populations. The identification of CD44posCD49fhiCD133/2hi XIC in ER-negative tumors may lead to expanded understanding of these tumors and ultimately the development of therapeutics designed to specifically target the cells. Cancer Res; 70(11); 4624–33. ©2010 AACR.
Regulation of Insulin-like Growth Factor–Mammalian Target of Rapamycin Signaling by MicroRNA in Childhood Adrenocortical Tumors
Authors: Doghman Mabrouka , Wakil Abeer El , Cardinaud Bruno , Thomas Emilie , Wang Jinling , Zhao Wei , Peralta-Del Valle Maria Helena C. , Figueiredo Bonald C. , Zambetti Gerard P. , Lalli Enzo 
Published: May 2010

Abstract
MicroRNAs (miRNAs) act at the posttranscriptional level to control gene expression in virtually every biological process, including oncogenesis. Here, we report the identification of a set of miRNAs that are differentially regulated in childhood adrenocortical tumors (ACT), including miR-99a and miR-100. Functional analysis of these miRNAs in ACT cell lines showed that they coordinately regulate expression of the insulin-like growth factor–mammalian target of rapamycin (mTOR)–raptor signaling pathway through binding sites in their 3′-untranslated regions. In these cells, the active Ser2448-phosphorylated form of mTOR is present only in mitotic cells in association with the mitotic spindle and midbody in the G2-M phases of the cell cycle. Pharmacologic inhibition of mTOR signaling by everolimus greatly reduces tumor cell growth in vitro and in vivo. Our results reveal a novel mechanism of regulation of mTOR signaling by miRNAs, and they lay the groundwork for clinical evaluation of drugs inhibiting the mTOR pathway for treatment of adrenocortical cancer. Cancer Res; 70(11); 4666–75. ©2010 AACR.
ADAMTS1 Contributes to the Acquisition of an Endothelial-like Phenotype in Plastic Tumor Cells
Authors: Casal Carmen , Torres-Collado Antoni Xavier , Plaza-Calonge María del Carmen , Martino-Echarri Estefanía , Ramón y Cajal Santiago , Rojo Federico , Griffioen Arjan W. , Rodríguez-Manzaneque Juan Carlos 
Published: May 2010

Abstract
Cancer stem cells have been hypothesized to explain tumor plasticity, including the capability to adopt distinct differentiation commitments. Among the mechanisms of tumor neovascularization, the ability of some malignant cells to mimic an endothelial phenotype has been recognized by a capacity to form matrix-enriched pseudovascular structures. In addition to the expression of genes associated with an endothelial nature, the molecular dynamism of specific microenvironments may also be critical. Here, we report the identification of the extracellular protease ADAMTS1 as a critical molecule for tumor cells to acquire endothelial-like properties. In a fibrosarcoma model, ADAMTS1 increased tumor growth rate in an angiogenesis-independent manner, influencing the tumor cells to display an exclusive endothelial-like gene signature. We documented the relevant expression of ADAMTS1 in aggressive and highly plastic melanoma and Ewing sarcoma cells. Notably, inhibiting ADAMTS1 action compromised the endothelial mimetic attributes observed in this setting. Our findings provide insights into how the tumor microenvironment can elicit endothelial mimicry by tumor cells. Cancer Res; 70(11); 4676–86. ©2010 AACR.
Telomere Loss as a Mechanism for Chromosome Instability in Human Cancer
Authors: Murnane John P. 
Published: May 2010

Abstract
Cancer cells commonly have a high rate of telomere loss, even when expressing telomerase, contributing to chromosome instability and tumor cell progression. This review addresses the hypothesis that this high rate of telomere loss results from a combination of four factors. The first factor is an increase in the frequency of double-strand breaks (DSB) at fragile sites in cancer cells due to replication stress. The second factor is that telomeres are fragile sites. The third factor is that subtelomeric regions are highly sensitive to DSBs, so that DSBs near telomeres have an increased probability of resulting in chromosome instability. The fourth factor is that cancer cells may be deficient in chromosome healing, the de novo addition of telomeres to the sites of DSBs, a mechanism that prevents chromosome instability resulting from DSBs near telomeres. Understanding these factors and how they influence telomere loss will provide important insights into the mechanisms of chromosome instability and the development of novel approaches for anti-cancer therapy. Cancer Res; 70(11); 4255–9. ©2010 AACR.