bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary squamous cell carcinoma of the ovary associated with endometriosis
Authors: Acién Pedro , Abad Maida , Mayol Maria‐José , Garcia Salvador , Garde Javier 
Published: September 2009

AbstractObjectiveTo analyze the clinical, therapeutic, and pathologic features of published cases presenting primary squamous cell carcinoma (SCC) of the ovary associated with endometriosis.MethodsA case report, 15 cases of infiltrating SCC of the ovary associated with or arising from endometriosis, and 1 case of synchronous carcinoma in situ in the cervix and ovary from a review of the literature were studied.ResultsYoung age, advanced stage of the disease, and hypogastric pain were frequent at the time of diagnosis. There was no ascites, but infiltration of neighboring organs was common. The tumor was associated with 80% patient mortality in the first few months. Adjuvant chemotherapy with paclitaxel and carboplatin or cisplatin appeared to improve the results.ConclusionPrimary SCC of the ovary associated with endometriosis is extremely rare and has a poor prognosis. The best therapeutic results are obtained with paclitaxel and carboplatin or cisplatin after radical surgery.
Progesterone Receptors Identified in Vascular Malformations of the Head and Neck
Authors: Duyka Landon J. , Fan Chun Y. , Coviello‐Malle Jean M. , Buckmiller Lisa , Suen James Y. 
Published: September 2009

OBJECTIVETo identify hormone receptors within vascular malformations (arteriovenous malformations [AVMs], venous malformations [VMs], and lymphatic malformations [LMs]) of the head and neck.STUDY DESIGNImmunohistochemical staining for estrogen receptor (ER) and progesterone receptor (PR) was performed on archival vascular malformation tissue collected from both pediatric and adult patients.SETTINGTertiary referral center from 2006 to 2008.SUBJECTS AND METHODSTwelve AVM, 10 VM, and eight LM specimens were stained for both ER and PR. Ten breast carcinoma specimens were used as controls, with the carcinoma cells serving as positive controls, and the endothelium and smooth muscle cells of the blood vessels serving as negative controls. Five normal supraglottic mucosal samples served as head and neck controls. The Fisher exact test was used for statistical analysis.RESULTSTen of the 12 (83%) AVM specimens stained diffusely positive for PR within the nuclei of the endothelium and smooth muscle of the malformed vessels (P < 0.0001). Five of the 10 (50%) VM specimens stained positive for PR (2 [20%] focal, 3 [30%] diffuse) within the nuclei of the endothelium and smooth muscle of the malformed vessels (P = 0.0325). Four of the eight (50%) LM specimens stained focally positive for PR within the nuclei of the endothelium of the malformed vessels (P = 0.0229). None of the vascular malformation specimens stained positive for ER.CONCLUSIONOur data suggest that PR, but not ER, is expressed in AVMs, VMs, and LMs of the head and neck.
Role of Acidic Mammalian Chitinase and Chitotriosidase in Nasal Polyps
Authors: Park Seong Kook , Cho Hong Wook , Heo Kyung Wook , Hur Dae Young , Lee Hyun‐Kyung 
Published: September 2009

OBJECTIVEChitin is a recognition element for tissue infiltration by innate cells implicated in allergy and helminth immunity, and this process can be negatively regulated by vertebrate chitinases. Acidic mammalian chitinase (AMCase) and chitotriosidase (ChT) have chitinolytic activity, but little is known about their roles in nasal polyps.STUDY DESIGNA prospective controlled study.SETTINGA tertiary referral center.SUBJECTS AND METHODSNineteen subjects with nasal polyps and 12 subjects with deviated nasal septums were recruited to obtain inferior turbinate mucosa samples. The expression levels of AMCase and ChT were compared in nasal polyp and inferior turbinate tissue samples. The tissue samples were analyzed by reverse transcription‐polymerase chain reaction, Western blotting, and immunohistochemical staining.RESULTSAMCase and ChT were detected in all nasal polyps and inferior turbinate tissues. AMCase and ChT messenger RNA and protein expression were significantly higher in nasal polyps than in inferior turbinate tissues. In nasal polyps, AMCase‐positive and ChT‐positive cells were detected in the epithelium, inflammatory cells, and submucosal gland.CONCLUSIONSAMCase and ChT may be important mediators in the pathogenesis of nasal polyps. Nasal polyps appear to have elevated levels of chitinases, and the presence or growth of chitin‐containing pathogens might enhance chitinase expression, resulting in nasal polyp formation and growth in susceptible individuals.
Voice Outcomes Following Repeated Surgical Resection of Laryngeal Papillomata in Children
Authors: Holler Theresa , Allegro Jennifer , Chadha Neil K. , Hawkes Michael , Harrison Robert V. , Forte Vito , Campisi Paolo 
Published: September 2009

OBJECTIVES1) To apply perceptual and acoustic voice assessments to children treated for juvenile‐onset recurrent respiratory papillomatosis (JORRP); 2) to compare voice outcomes following treatment for JORRP using microdebrider versus carbon dioxide (CO2) laser.STUDY DESIGNProspective cohort study.SETTINGThis study was conducted at a tertiary pediatric academic center (March 2008‐March 2009).SUBJECTS AND METHODSChildren with active JORRP were assessed using perceptual and acoustic voice analysis following treatment with either CO2 laser or microdebrider. Outcome measures included overall severity rating, jitter, shimmer, and noise‐to‐harmonic ratio (NHR). The unpaired Student t test and Pearson correlation tests were used to explore the statistical significance of hypothesis tests.RESULTSEleven patients (8 male, 3 female) aged three to 17 years were enrolled. There were six children in the CO2 laser cohort and five children in the microdebrider cohort. The immediate postoperative scores were significantly lower in the microdebrider cohort (vs the CO2 cohort) for jitter, shimmer, NHR, and perceptual scores (P < 0.05), indicating a better voice quality in the microdebrider group. Jitter, shimmer, and NHR showed a significant positive correlation with the proportion of CO2 laser procedures (P < 0.05).CONCLUSIONThis is the first study to use perceptual and objective acoustic evaluations to compare voice outcomes following microdebrider or CO2 laser treatment of JORRP. The results of this study suggest that treatment with the microdebrider results in a better immediate and early postoperative voice outcome. Moreover, the data demonstrate a correlation of worsening voice quality with increased exposure to the CO2 laser.
Topical Clindamycin in Post‐Adenotonsillectomy Analgesia in Children: A Double‐Blind, Randomized Clinical Trial
Authors: Miura Mauricio Schreiner , Saleh Catia , de Andrade Marina , Assmann Melina , Lima Lucélia Hernandes , Faibes Lubianca Neto José 
Published: September 2009

OBJECTIVESTonsillectomy, with or without adenoidectomy, is one of the most common surgical procedures in pediatric otolaryngology. Pain is the main cause of morbidity in the postoperative period, where it is serious in some cases, leading to odynophagia and resultant complications such as dehydration. We evaluated the effect of topical clindamycin in the reduction of oropharyngeal pain in children who underwent adenotonsillectomy. Secondary outcomes were otalgia, analgesic use, oral bacterial count, type of diet, secondary bleeding, vomiting, fever, and weight loss.STUDY DESIGNDouble‐blind, randomized clinical trial.SETTINGTertiary hospital.SUBJECTS AND METHODSEighty‐two children of both sexes between four and 12 years of age who underwent adenotonsillectomy were allocated to receive topical clindamycin or placebo in the immediate preoperative, intraoperative, and eight‐to12‐hours postoperative periods. Pain was measured using a faces pain scale for five days.RESULTSReduction of oropharyngeal pain was significant with the use of clindamycin only on the first postoperative day (95% confidence interval, 2.22 to 4.41 [clindamycin] vs 4.53 to 6.3 [placebo]; P =. 002). No difference was observed in the aerobic and anaerobic counts by tongue swab between premedication and third‐postoperative‐day samplings. There were no differences with respect to reduction in otalgia, paracetamol use, return to normal diet, variation in weight, secondary hemorrhage, vomiting, and fever.CONCLUSIONThe use of topical clindamycin was beneficial in reducing pain on the first postoperative day, without effect on subsequent days. Future investigations could examine the use of topical clindamycin not only in the first 12 hours but also during five days of follow‐up.
Visual Analog Scale (Vas) and Nasal Obstruction in Persistent Allergic Rhinitis
Authors: Ciprandi Giorgio , Mora Francesco , Cassano Michele , Gallina Anna Maria , Mora Renzo 
Published: September 2009

OBJECTIVENasal airflow resistance, as measured by rhinomanometry, is frequently impaired in allergic rhinitis (AR). However, rhinomanometry is scarcely available. The aim of this study was to verify the suitability of the use of visual analog scales (VAS) as a surrogate for rhinomanometry in quantifying nasal obstruction in patients with persistent allergic rhinitis.STUDY DESIGNProspective study on patients with allergic rhinitis.SETTINGENT clinic.SUBJECTS AND METHODSFifty patients (27 males, mean age 23 years, SD 2.24) were studied. VAS for nasal obstruction and other AR symptoms and rhinomanometry were performed in all patients.RESULTSA significant, very strong correlation has been observed between VAS for nasal obstruction and nasal airflow resistance (Spearman r = 0.879, P < 0.001). Moreover, a significant correlation exists between VAS for rhinorrhea and resistance (Spearman r = 0.313, P = 0.027).CONCLUSIONThe use of VAS for assessing the nasal obstruction appears clinically relevant in that it allows, with good reliability, the quantification of this symptom in the absence of rhinomanometry.
Relationship Between Clinical Measures and Histopathologic Findings in Chronic Rhinosinusitis
Authors: Soler Zachary M. , Sauer David A. , Mace Jess , Smith Timothy L. 
Published: September 2009

OBJECTIVEDescribe detailed histopathologic findings from a cohort of patients with chronic rhinosinusitis and evaluate whether histologic measures correlate with baseline clinical factors.STUDY DESIGNCross‐sectional study with planned data collection.SETTINGTertiary medical center.SUBJECTS AND METHODSAdult patients with chronic rhinosinusitis were prospectively enrolled and demographic data and medical comorbidities recorded. Disease severity was measured by computed tomography (CT), endoscopy, Smell Identification Test (SIT), the Chronic Sinusitis Survey, Rhinosinusitis Disability Index, and SF‐36 General Health Survey. Mucosal specimens were assessed for the presence of mucosal inflammation, including cellular (eosinophils, neutrophils, lymphocytes, mast cells, plasma cells, macrophages), epithelial (squamous metaplasia, basement membrane thickening, goblet cells), and stromal markers (subepithelial edema, fibrosis). Histopathologic findings were correlated to baseline clinical factors.RESULTSA total of 147 subjects were enrolled with histologic samples available for review. Presence of inflammatory markers was diverse, with lymphocytes present in 100 percent of subjects, eosinophils in 49.7 percent, and neutrophils found in 0.7 percent. Total eosinophil counts correlated with the presence of nasal polyposis (r = −0.367; P < 0.001), asthma (r = 0.264; P = 0.001), and aspirin intolerance (r = 0.279; P = 0.001). Mucosal eosinophilia correlated with worse disease severity on CT (r = 0.414; P < 0.001), endoscopy (r = 0.376; P < 0.001), and SIT (r = −0.253; P = 0.002), with the highest correlations seen in subgroups without nasal polyps. Histopathologic findings did not significantly correlate with any quality‐of‐life measure.CONCLUSIONMucosal eosinophilia correlates with objective disease severity as defined by CT, endoscopy, and SIT scores. Although other histologic markers of inflammation are present, none show similar correlations. The presence of mucosal eosinophils does not correlate with quality‐of‐life scores.
Biofilms Correlate with TH1 Inflammation in ihe Sinonasal Tissue of Patients with Chronic Rhinosinusitis
Authors: Hekiert Adrianna M. , Kofonow Jennifer M. , Doghramji Laurel , Kennedy David W. , Chiu Alexander G. , Palmer James N. , Leid Jeffery G. , Cohen Noam A. 
Published: September 2009

OBJECTIVEDetermine the prevalence of bacterial biofilms in surgical chronic rhinosinusitis (CRS) patients and characterize the inflammatory response associated with biofilm CRS.STUDY DESIGNCross‐sectional.SETTINGTertiary care academic center.SUBJECTS AND METHODSSinonasal mucosa and peripheral blood were collected from 60 CRS patients. Mucosal biofilms were demonstrated by scanning electron microscopy. Leukocyte subpopulations were determined by flow cytometry. Cytokines were identified with a luminex‐based assay on the lysate of homogenized tissue or plasma.RESULTSOf the 60 samples, 17 were determined to be positive for the presence of biofilms. Oral steroid‐naive CRS patients with biofilm demonstrated a local TH1 inflammatory response with significantly elevated levels of interferon‐γ (INF‐γ), granulocyte colony‐stimulating factor, macrophage inflammatory protein‐1 β, and neutrophils in the sinonasal mucosa. No differences were present at the systemic level.CONCLUSIONSinonasal bacterial biofilms correlate to a TH1 skewed local but not systemic inflammatory response in CRS. This difference is abrogated by the use of oral steroids.
Comparison of Ligasure Vessel Sealing System, Harmonic Scalpel, and Conventional Hemostasis in Total Thyroidectomy
Authors: Pons Yoann , Gauthier Jérome , Ukkola‐Pons Elsa , Clément Philippe , Roguet Eric , Poncet Jean‐Luc , Conessa Claude 
Published: September 2009

OBJECTIVEThe aim of the study was to compare the efficiency, safety, and cost of the different methods of hemostasis (conventional hemostasis versus LigaSure vessel sealing system [LVSS] versus harmonic scalpel) currently available for thyroid surgery.STUDY DESIGNRandomized, controlled trial.SETTINGThe study was conducted from September 2007 to December 2008 in a university hospital.PATIENTS AND METHODSSixty patients (48 females and 12 males) underwent a total thyroidectomy for multinodular goiter. They were randomly assigned into three groups: group one (n = 20), conventional hemostasis; group two (n = 20), LigaSure; and group three (n = 20), harmonic scalpel.RESULTSFor group three, the mean operative time was 37 minutes shorter than group one (P < 0.001) and eight minutes shorter than group two (P = 0.04). The complications rate was similar among the three groups. The mean postoperative paracetamol consummation in group one was 1.4 g greater than in group two (P = 0.016) and 1.3 g greater than in group three (P = 0.02). The overall average operative cost was 11 and 85 dollars cheaper for groups two and three than for group one, respectively (P < 0.001).CONCLUSIONTotal thyroidectomy using the harmonic scalpel was the fastest procedure because it was bloodless, and hemostasis and sectioning were controlled with a single instrument; it was, therefore, the most inexpensive procedure because of the reduction of operative time and staff cost. The operative safety was similar for all three procedures. In our series, the harmonic scalpel and the LVSS caused less pain than the conventional hemostasis.
HER2 Expression Predicts Improved Survival in Patients with Cervical Node‐Positive Head and Neck Squamous Cell Carcinoma
Authors: Tse Gary M. , Yu Kwok Hung , Chan Anthony W. H. , King Ann D. , Chen George G. , Wong Ka‐Tak , Tsang Raymond K. Y. , Chan Amy B.W. 
Published: September 2009

OBJECTIVETo investigate the prognostic value of HER2 and p63 expression in head and neck squamous cell carcinoma (HNSCC).STUDY DESIGNA case review of 186 HNSCCs from the oral tongue, palate, maxillary sinus, floor of mouth, oropharynx, hypopharynx, and larynx.SUBJECTS AND METHODSAll primary tumor specimens were evaluated by immunohistochemistry for HER2 and p63 expressions, which were correlated with clinical parameters including age, sex, grade, lymph node metastases, stage, and survival.RESULTSOne hundred forty‐one patients had stage III‐IV disease and 109 had lymph node metastases. For all cases, T and N stages were significant prognostic predictors for both overall and disease‐free survivals. In the node‐positive subgroup, T stage and HER2 expression were significant prognostic predictors for both overall and disease‐free survivals.CONCLUSIONHER2 may be associated with longer survival in node‐positive patients with HNSCC.
Planned Neck Dissection Following Primary Chemoradiation for Advanced‐Stage Head and Neck Cancer
Authors: Sabatini Peter R. , Ducic Yadranko 
Published: September 2009

OBJECTIVESTo determine the prevalence of residual cancer in planned neck dissection specimens for advanced‐stage squamous cell carcinoma following chemoradiation.STUDY DESIGNA case series.SETTINGA single‐surgeon community‐based head and neck practice.SUBJECTS AND METHODSTwenty‐six patients were identified during 2000 to 2007. All patients were treated with external beam radiation; the average dose to the neck was 60 Gy (range 50‐72 Gy). Concurrent chemotherapy was given with cisplatin and 5‐fluorouracil. Patients presenting with greater than N2 cervical disease and at least one node greater than 3 cm were considered advanced. Post‐chemoradiation physical examinations were performed by the primary surgeon and oncologist. Absence of physical evidence of disease was deemed a complete clinical response.RESULTSFourteen of 21 (67%; 95% confidence interval [CI], 0.449‐0.854) patients were found to have carcinoma in their neck specimens. Seven patients were noted to have a clinically complete response, and two of seven (29%; 95% CI, 0.053‐0.659) patients with a clinically complete response were found to have carcinoma in their neck specimens. Fourteen patients were noted to have an incomplete response to therapy. Two of these 14 (14%; 95% CI, 0.026‐0.419) patients had negative pathology in their neck dissection specimens. Three patients had local recurrence and succumbed to their disease.CONCLUSIONPlanned neck dissection in the setting of advanced neck disease following chemoradiation should remain an important consideration when counseling patients presenting with advanced cervical metastasis from squamous cell head and neck cancer.
Proposal for Staging Airway Hemangiomas
Authors: Perkins Jonathan A. , Chen Eunice Y. , Hoffer Fredric A. , Manning Scott C. 
Published: September 2009

OBJECTIVETo describe a method of airway infantile hemangioma staging using standardized assessment of airway narrowing, and hemangioma location and volume, as determined with endoscopy and CT angiography.STUDY DESIGNCase series with chart review.SETTINGTertiary pediatric hospital, 2003‐2008.SUBJECTS AND METHODSSubjects included airway hemangioma patients evaluated at a tertiary pediatric hospital. Data collected were age at first symptoms, diagnostic evaluation, percent airway compromise, and estimated hemangioma volume. Data were analyzed with descriptive and Fisher exact statistics.RESULTSTwelve patients were identified and seven had complete data sets. Mean age at first symptoms was 1.9 months (SD 1.09 months, range 0.5‐4 months). Evaluation consisted of nasopharyngoscopy, microlaryngoscopy, CT angiography, and/or MRI. Mean laryngeal airway narrowing was estimated at 63.75 percent (SD 19.0%, range 40%‐90%). Total hemangioma volume was less in patients with isolated (focal) endolaryngeal hemangiomas compared with airway hemangiomas associated with extralaryngeal (segmental) hemangiomas. Airway hemangioma stages were stage one (5 of 12; 41.6%), stage two (6 of 12; 50.0%), and stage three (1 of 12; 8.3%).CONCLUSIONThis method of airway hemangioma staging may be applicable to treatment planning and used to measure treatment outcomes.
Prognostic Relevance of CD105‐Assessed Microvessel Density in Laryngeal Carcinoma
Authors: Zvrko Elvir , Mikic Anton , Vuckovic Ljiljana , Djukic Vojko , Knezevic Milan 
Published: September 2009

OBJECTIVETo examine immunohistochemical expression of CD105 among patients with laryngeal cancer and investigate the prognostic significance of CD105‐assessed microvessel density (MVD).STUDY DESIGNCross‐sectional study.SETTINGUniversity hospital.SUBJECTS AND METHODSThe study comprised 80 patients with laryngeal squamous cell carcinoma who underwent complete excision. Clinicopathological data were collected retrospectively. Immunohistochemical analysis was performed with CD105 (endoglin) antibody. Positive‐stained microvessels for CD105 were counted on hot spots of tumors at ×200 magnification.RESULTSAverage CD105‐assessed MVD in considered laryngeal squamous cell carcinomas (SCCs) was 12.9 (SD 3.84). High expression of CD105 correlated significantly with advanced T (tumor) classification (P = 0.008), advanced TNM (tumor, node, metastasis) stage (P = 0.001), tumor recurrence (P = 0.001), and age ≥65 years (P = 0.026). The multivariate logistic regression showed that a high CD105+ MVD (odds ratio [OR] 4.27; P = 0.019) and advanced TNM stage (OR 3.72; P = 0.047) were independent markers of tumor recurrence. High MVD, advanced clinical stage, the presence of lymph node metastasis at the time of diagnosis, and age <66 years were associated with worse disease‐free survival. Cox regression analysis revealed that expression of CD105 (P = 0.016) and advanced clinical stage (P = 0.05) were the independent factors for disease‐free survival.CONCLUSIONThe present results suggest that MVD evaluation with CD105 is a promising prognostic factor for the outcome of patients with laryngeal SCC. CD105‐assessed MVD could help to identify patients with more aggressive disease and increased risk of developing malignancy recurrence after treatment.
Mutation Analysis of Slc26a4 in Mainland Chinese Patients with Enlarged Vestibular Aqueduct
Authors: Reyes Samuel , Wang Guojian , Ouyang Xiaomei , Han Bing , Du Li Lin , Yuan Hui Jun , Yan Denise , Dai Pu , Liu Xue‐Zhong 
Published: September 2009

OBJECTIVEWe have characterized the spectrum of SLC26A4 mutations and clinical features in a population of mainland Chinese patients with nonsyndromic sensorineural hearing loss (SNHL) and enlarged vestibular aqueduct (EVA).STUDY DESIGNCross‐sectional clinical genetic study.SETTINGTertiary care outpatient otolaryngology clinic.METHODSA total of 32 subjects identified with bilateral EVA using high‐resolution CT were screened for mutations in SLC26A4 by denaturing high‐performance liquid chromatography and direct sequencing methods.RESULTSA total of 13 different mutations were identified in the SLC26A4 gene, five of which are novel. A total of 88 percent of the patients harbored biallelic mutations, 11 patients were homozygotes, and 17 were compound heterozygotes. Four patients were found to carry a single SLC26A4 mutation. The IVS7‐2A>G mutation was the most frequent, accounting for 60 percent of the mutant alleles. We have not found any correlations between the type of SLC26A4 mutations and the type, degree, and progression of hearing loss. There are significant proportions of patients with asymmetric (26%), progressive (32%), or fluctuating hearing loss (21%).CONCLUSIONOur data confirm the high prevalence of SLC26A4 mutations in Chinese patients with SNHL and EVA. We could not establish any relationship between genotype and pheno‐type. However, the high incidence of asymmetric, progressive, and fluctuating hearing loss found in the current study indicates that patients with those features should be routinely screened for SLC26A4 mutation in addition to diagnosis of EVA using CT or MRI.