bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and usability testing of an online platform for provider training and implementation of cognitive-behavioral therapy guided self-help for eating disorders
Authors: D'Adamo Laura , Laboe Agatha , Goldberg Jake , Howe Carli , Fennig Molly , DePietro Bianca , Firebaugh Marie-Laure , Cooper Zafra , Wilfley Denise , Fitzsimmons-Craft Ellen 
Published: May 2024

Abstract

Background
Most individuals with eating disorders (EDs) do not receive treatment, and those who do receive care typically do not receive evidence-based treatment, partly due to lack of accessible provider training. This study developed a novel “all-in-one” online platform for disseminating training for mental health providers in cognitive-behavioral therapy guided self-help (CBTgsh) for EDs and supporting its implementation. The aim of the study was to obtain usability data from the online platform prior to evaluating its effects on provider training outcomes and patient ED symptom outcomes in an open pilot trial.
Methods
Nine mental health provider participants (n = 4 in Cycle 1; n = 5 in Cycle 2) and 9 patient participants (n = 4 in Cycle 1; n = 5 in Cycle 2) were enrolled over two cycles of usability testing. In Cycle 1, we recruited providers and patients separately to complete brief platform testing sessions. In Cycle 2, we recruited provider-patient dyads; providers completed training using the platform and subsequently delivered CBTgsh to a patient for three weeks. Usability was assessed using the System Usability Scale (SUS), the Usefulness, Satisfaction, and Ease of Use Questionnaire (USE), and semi-structured interviews.
Results
Interview feedback converged on two themes for providers (applicability of program for real-world use, platform structure and function) and two themes for patients (barriers and facilitators to engagement, perceived treatment effects). SUS and USE scores were in the “average” to “good” ranges across cycles.
Conclusions
Findings from this study demonstrate preliminary feasibility and acceptability of the online platform. Data collected in this study will inform further refinements to the online platform. The platform’s effects on provider training outcomes and patient ED symptom outcomes will be evaluated in an open pilot trial. Given the wide treatment gap for EDs and barriers to dissemination and implementation of evidence-based treatments, the online platform represents a scalable solution that could improve access to evidence-based care for EDs.
Induction of tolerogenicity following a molecular dialogue between HTLV-1-infected T cells and dendritic cells
Authors: Dutartre Hélène , Carcone Auriane , Mortreux Franck , Alais Sandrine , Mathieu Cyrille , Journo Chloe 
Published: May 2024

Abstract

Manipulation of immune cell functions, independently of direct infection of these cells, emerges as a key process in viral pathophysiology. Chronic infection by Human T-cell Leukemia Virus type 1 (HTLV-1) is associated with immune dysfunctions, including misdirected responses of dendritic cells (DCs). Here, we interrogate the ability of HTLV-1-infected T cells to indirectly manipulate human DC functions. We show that upon coculture with chronically infected T cells, monocyte-derived DCs (MDDCs) fail to fully mature. We further show that exposure to HTLV-1-infected T cells induces a unique transcriptional signature in MDDCs, which differs from a typical maturation program, and which is correlated with a dampened ability of HTLV-1-exposed MDDCs to subsequently respond to restimulation. Induction of this tolerogenic behavior is not strictly dependent on capture of HTLV-1 viral particles by MDDCs, nor on cell-cell contacts between HTLV-1-infected T cells and MDDCs, but is instead the result of a molecular dialogue between HTLV-1-infected T cells and MDDCs upon coculture, illustrating how HTLV-1 might indirectly induce a local tolerogenic immune microenvironment suitable for its own persistence.
SEMNet: A Simple and Efficient MLP-based Network for 3D Face Point Clouds Landmarks Localization
Authors: Lei Mingyang , Song Hong , Fu Tianyu , Xiao Deqiang , Ai Danni , Fan Jingfan , Yang Yifei , Gu Ying , Yang Jian 
Published: May 2024

Abstract

Accurately localizing landmarks on 3D faces is critical for various applications, such as expression recognition, facial surgery navigation, and lip shape analysis. Existing landmarks localization methods generally contain complex calculation processes, which may affecting the efficiency. To address this problem, we propose a Simple and Efficient MLP-based Network (SEMNet) for landmarks localization. We first design a lightweight enhanced geometric affine module to adaptively transform point features in local region, for improving performance and generalization. Then, to fully utilize the rotation information of the face, a rotation constraint auxiliary branch is introduced for assisting in locating landmarks. In addition, to generate more accurate results, we propose a residual graph convolution discriminator to distinguish predicted locations from real face point clouds locations. Experimental results on two public datasets (FRGC v2 and Bosphorus) show that our method achieves high accuracy and efficiency compared to state-of-the-art methods. The project page is available at https://github.com/leimingyangde/SEMNet.
Comparative biochemical and pharmacodynamic analyses of Asarum heterotropoides Fr. Schmidt var. mandshuricum (Maxim) Kitag and Asarum sieboldii Miq var. seoulense Nakai roots
Authors: Wang Zhiqing , Li Huiling , Zhao Guangyuan , Wang Yanhong , Xu Xuanwei , Wang Yingping , Zhang Ze , Wang Guanghui 
Published: May 2024

Abstract

Background
Asarum heterotropoides and Asarum sieboldii are commonly used in traditional Chinese medicine. However, less is known about how they differ in terms of essential oil (EO) and ethanol extract (EE) content and composition. Moreover, the impact of various geographical locations on the essential oil (EO), ethanol extract (EE), and asarinin content of different Asarum samples remains unknown. We tested four root drying methods, i.e. soil removal and shade drying (P1), water washing and shade drying (P2), water washing and drying at 30 ℃ (P3) and 40 ℃ (P4). We used LC-MS and GC-MS to investigate these differences. We also investigated the pharmacodynamic effects of EO and EE.
Result
Overall, the EO, EE and asarinin contents of the analysed samples were 19.21–51.53 µL.g-1, 20.00–45.00 µL.g-1 and 1.268–2.591 mg.g-1, respectively. P1 treatment yielded the lowest volatile oil content as compared to the other three treatments. GC-MS analysis revealed 78 EO components. Among the six major EO components, eucarvone, 3,5-dimethoxytoluene and methyl eugenol were higher in A. heterotropoides than in A. sieboldii. However, the latter had a higher myristicin content. LC-MS analysis identified 888 EE components in roots and leaves of A. heterotropoides and A. sieboldii; 317 differentially accumulated metabolites were identified. EO and EE showed a dose-dependent reduction in the degree of swelling and an increase in the inhibition rate of drug concentration on acetic acid writhing in mice. Asarum EO proved to be more effective than EE in the pharmacodynamic study.
Conclusion
We conclude that Asarum species show inter- and intra-specific differences in EO, EE content and composition, which may influence the pharmacodynamics of Asarum root extracts.
Teacher and Student Experiences in a Gender-Inclusive Secondary Computer Science Program
Authors: Michael Karlin  , Ottenbreit-Leftwich Anne , Liao Yin-Chan Janet 
Published: May 2024

A significant gender gap continues to exist within computer science (CS) education, despite a nationwide emphasis in the U.S. on increasing CS education equity and access. To explore this issue, we conducted an ethnographic case study within a classroom at Forest View High School (FVHS, pseudonym) where girls’ participation in CS was consistently higher than state averages over 12 years. We sought to understand teacher and student experiences within this gender-inclusive program. Data were collected over three months through observations, interviews, course documents, and reflections. Results indicate three strategies for supporting a more gender-inclusive classroom: (1) Providing personalized and relevant learning experiences; (2) modeling a growth mindset; and (3) creating a welcoming environment. Implications for practice include providing assignment choice, providing opportunities to learn from failure, and building personal relationships with students. Overall, teachers can act as agents of social change within the CS classroom, and play an essential, central role in broadening participation and equity initiatives. However, this work must also be supported by administrators, counselors, and other school stakeholders to be effective for enacting change.
Occurrence and potential environmental risk assessment of alkylphenols and bisphenols in surface water collected in rivers flowing through Bac Ninh, Vietnam
Authors: Thi Thu Nguyen , Thi Quynh Mai Duong , Cam Tu Vu , Thi Thao Nguyen , Dinh Binh Chu , Hoang Anh Nguyen , Van Hoi Bui 
Published: May 2024

ABSTRACT

In recent decades, increasing attention has been directed toward the effects of alkylphenols and bisphenols due to their demonstrated endocrine-disruptive effects. This study investigated the occurrence and potential risk assessment of two alkylphenols and seven bisphenols in surface water collected from rivers (Cau River, Duong River, and Thai Binh River) flowing through Bac Ninh province, one of the pivotal economic regions in the North of Vietnam. The results demonstrated that these compounds were widely distributed in the rivers. The average concentrations were ranked as follows: 4-tert-octylphenol (4-t-OP) (91.2 ng/L) &gt; 4-nonylphenol (4-NP) (78.9 ng/L) &gt; bisphenol S (BPS) (72.4 ng/L) &gt; bisphenol A (BPA) (5.6 ng/L) &gt; bisphenol F (BPF) (below method detection limit) with detection frequencies of 100% (except for BPF of 23%). The presence of alkylphenols and bisphenols in aquatic environments closely correlates with anthropogenic activity. The environmental risk assessment was carried out based on the Risk Quotient (RQ) evaluation, indicating that 4-NP poses medium risk in all three rivers. In addition, 4-t-OP, which is more toxic than 4-NP, poses high risk to aquatic organisms in the Duong River (RQ = 1.1), while BPA and BPS show low risk to aquatic organisms in three rivers (RQ &lt; 0).
A soft-sensor approach for predicting an indicator virus removal efficiency of a pilot-scale anaerobic membrane bioreactor (AnMBR)
Authors: Kadoya Syun-suke , Zhu Yifan , Chen Rong , Rong Chao , Li Yuyou , Sano Daisuke 
Published: May 2024

ABSTRACT

The anaerobic membrane bioreactor (AnMBR) is a promising technology for not only water reclamation but also virus removal; however, the virus removal efficiency of AnMBR has not been fully investigated. Additionally, the removal efficiency estimation requires datasets of virus concentration in influent and effluent, but its monitoring is not easy to perform for practical operation because the virus quantification process is generally time-consuming and requires specialized equipment and trained personnel. Therefore, in this study, we aimed to identify the key, monitorable variables in AnMBR and establish the data-driven models using the selected variables to predict virus removal efficiency. We monitored operational and environmental conditions of AnMBR in Sendai, Japan and measured virus concentration once a week for six months. Spearman's rank correlation analysis revealed that the pH values of influent and mixed liquor suspended solids (MLSS) were strongly correlated with the log reduction value of pepper mild mottle virus, indicating that electrostatic interactions played a dominant role in AnMBR virus removal. Among the candidate models, the random forest model using selected variables including influent and MLSS pH outperformed the others. This study has demonstrated the potential of AnMBR as a viable option for municipal wastewater reclamation with high microbial safety.
Emicizumab as a Promising Form of Therapy for Type A Hemophilia - A
Review of Current Knowledge from Clinical Trials
Authors: Grabowska Katarzyna , Grzelak Michalina , Zhao Lin-Yong , Płuciennik Elżbieta , Pasieka Zbigniew , Kciuk Mateusz , Gielecińska Adrianna , Smakosz Aleksander K. , Kałuzińska-Kołat Żaneta , Kołat Damian 
Published: May 2024

:
Hemophilia is a plasma bleeding disorder characterized by a deficiency of certain blood
clotting factors. The most common forms of this disease, i.e., type A and type B, affect approximately
400,000 people worldwide. Without appropriate treatment ensuring the proper coagulation
cascade, this disease may lead to serious disability. Minimizing patient discomfort is possible via
replacement therapy, consisting of the substitution of a missing coagulation factor via intravenous
administration. Frequent medication and the risk related to factor inhibitors are significant disadvantages,
necessitating the improvement of current therapies or the development of novel ones.
This review examines the humanized bispecific antibody Emicizumab which ensures hemostasis
by mimicking the action of the coagulation factor VIII, a deficiency of which causes type A hemophilia.
The paper outlines the topic and then summarizes available clinical trials on Emicizumab
in type A hemophilia. Several interventional clinical trials have found Emicizumab to be
effective in decreasing bleeding episodes and raising patient satisfaction among various hemophilia
A populations. Current Emicizumab-related trials are forecast to be completed between
2024 and 2030, and in addition to congenital hemophilia A, the trials cover acquired hemophilia A
and patients playing sports. Providing a more comprehensive understanding of Emicizumab may
revolutionize the management of hemophilia type A and improve quality of life. Conclusively,
Emicizumab is a gentler therapy owing to subcutaneous delivery and fewer injections, which reduces
injection-site reactions and makes therapy less burdensome, ultimately decreasing hospital
visits and indirect costs.
Can Gender-Specific Renal and Visceral Fat Evaluated by CT Predict the
Fuhrman Nuclear Classification of Clear Cell Renal Cell Carcinoma?
Authors: Li Xiaoxia , Lin Jinglai , Guo Yi , Lin Dengqiang , Zhou Jianjun 
Published: May 2024

Background:
Evidence of the association between obesity and renal cell carcinoma progression is contradictory. The effects of renal cell carcinoma on fat
distribution are still unknown.

Objective:
The goal of this study was to determine the ability of various forms of fat deposition to predict the Fuhrman nuclear grade of clear cell renal cell
carcinoma [ccRCC].

Methods:
This retrospective study included 320 patients with pathologically proven ccRCC [215 men and 105 women; 263 low-grade ccRCC and 57 highgrade
ccRCC]. Based on computed tomography scans, adipose tissue in various body regions was classified into the perirenal fat area [PFA],
visceral fat area [VFA], total fat area [TFA], subcutaneous fat area [SFA], and hepatic steatosis [HS]. Subsequently, the relative VFA [rVFA] was
computed. Age, sex, body mass index, and maximal tumor diameter were also regarded as clinical factors. Univariate and multivariate logistic
regression studies were conducted to evaluate whether there was an association between body fat composition and the Fuhrman classification and
whether it was related to gender.

Results:
After correcting for age, males with low-grade ccRCC exhibited higher TFA [257.6 vs. 203.0, p = 0.002], VFA [151.6 vs.115.5, p = 0.007], SFA
[106.0 vs. 87.5, p = 0.015], PFA [55.1 vs. 30.4, p < 0.001], and HS [18% vs. 0%, p = 0.031] than those with high-grade ccRCC. There was no
significant difference among rVFA in males. In females, there was no significant difference in any of the parameters. VFA and PFA remained
independent predictors for high-grade ccRCC in males in both the monovariate [VFA: odds ratio [OR] 0.992, 95% confidence interval [CI]
0.987–0.997, p = 0.004; PFA: OR 0.949, 95% CI 0.930–0.970, p < 0.001] and multivariate [VFA: OR 1.028, 95% CI 1.001–1.074, p < 0.001;
PFA: OR 0.878, 95% CI 0.833–0.926, p < 0.001] models.

Conclusion:
Gender-specific adipose tissue in different locations demonstrated varied values for predicting high-grade ccRCC and may be utilized as an
independent predictor of high-grade ccRCC in male patients.

conclusion:
Gender-specific adipose tissue in different locations demonstrated varied values for predicting high-grade ccRCC and may be utilized as an independent predictor of high-grade ccRCC in male patients.

other:
Sex-specific adipose tissue in various places exhibits variable values for high-grade ccRCC prediction.
Exploration of Potential Targets and Molecular Mechanisms of the Yiqi
Jianpi Tongqiao Formula in Treating Allergic Rhinitis Mouse Model based
on Network Pharmacology and Molecular Docking
Authors: Huang Sihong , Huang Yue 
Published: May 2024

Objective:
To investigate the therapeutic effect of Yiqi Jianpi Tongqiao (YJT) formula (Hedysarum Multijugum Maxim, Magnoliae Flos, Xanthii Fructus, Notopterygii Rhizoma
Et Radix, Kaempferiae Rhizoma, Acoritataninowii Rhizoma, Saposhnikoviae Radix) on an
allergic rhinitis mouse model, and to explore the active ingredients, key targets, and
molecular mechanisms of this formula using network pharmacology and molecular docking
methods

Methods:
An allergic rhinitis mouse model was established to observe changes in rhinitis symptoms, nasal mucosal morphology, and serum indicators after administering the YJT formula.
The TCMSP, GeneCards, OMIM, and DisGeNET databases were used to screen for the active
ingredients, action targets, and disease targets of the YJT formula. The Cytoscape software was
used to construct a network of the active ingredients and action targets. The protein-protein interaction (PPI) network was used to predict hub genes. The corresponding active compounds
with the hub genes' highest oral bioavailability (OB) values were identified, followed by molecular docking analysis.

Results:
Animal experiments demonstrated that the YJT formula reduced rhinitis symptoms
(nasal itching, runny nose, and face scratching) in allergic rhinitis mice, as well as decreased
nasal mucosal inflammatory reactions and serum inflammatory indicators (histamine, OVAspecific IgE, IL-1β levels). Furthermore, 63 active components and 101 potential indicator targets of the YJT formula were identified, along with 5 hub genes (IL6, AKT1, IL1B, VEGFA,
and PTGS2), and the corresponding active compounds with the highest OB values were quercetin, aloe-emodin, and denudanolide b. Molecular docking results revealed the binding energy
between quercetin, aloe-emodin, denudanolide b and 5 hub genes (IL6, AKT1, IL1B, VEGFA,
and PTGS2) were -5.78 to -10.22 kcal/mol, the binding energy between dexamethasone and 5
hub genes were -6.3 to -9.7 kcal/mol. In addition, GO and KEGG analysis suggested significant
enrichment of these genes in biological processes such as response to lipopolysaccharide, response to molecule of bacterial origin, and response to reactive oxygen species, as well as signaling pathways like AGE-RAGE signaling pathway in diabetic complications, Lipid and atherosclerosis, and IL-17 signaling pathway.

Conclusion:
The YJT formula has therapeutic effects in an allergic rhinitis mouse model,
with the main active components being quercetin, aloe-emodin, and denudanolide b, and the
key targets being IL6, AKT1, IL1B, VEGFA, and PTGS2, involving multiple signaling
pathways.
A Short Appraisal on Nano-biosensors for Epigenetic Changes Detection: A Transformative Innovation
Authors: Singh Dilpreet 
Published: May 2024

Abstract:
This mini-review article focuses on the recent advancements in nano-biosensors for
the detection of epigenetic changes, a burgeoning field at the intersection of nanotechnology and
cancer diagnostics. Epigenetic modifications, including DNA methylation, histone modification,
and non-coding RNA expression, play a crucial role in cancer progression and drug resistance.
The advent of nano-biosensors has introduced highly sensitive and specific methods for detecting
these changes, surpassing the capabilities of traditional diagnostic tools. This article delves
into various nano-biosensors, such as gold nanoparticles, quantum dots, carbon nanotubes, and
graphene oxide sensors, highlighting their unique properties and applications in detecting epigenetic
markers. It emphasizes the significance of early and accurate detection of epigenetic alterations
in cancer, which opens new pathways for early diagnosis, monitoring treatment efficacy,
and developing personalized therapeutic strategies. The review also addresses the technical challenges
and limitations of current nano-biosensor technologies, including issues related to sensitivity,
specificity, and biocompatibility. Furthermore, it explores the ethical and safety considerations
in the clinical application of these nanotechnologies. The discussion extends to the potential
future developments in this field, emphasizing interdisciplinary research and the integration
of artificial intelligence for data analysis. This comprehensive overview of nano-biosensors for
epigenetic change detection underscores their transformative potential in cancer research, offering
insights into their current state, challenges, and future prospects in advancing personalized
cancer care.
Drug-induced Tongue Disorders: A Comprehensive Literature Review
Authors: Amiri Shiva , Nikvarz Naemeh , Sabouri Salehe 
Published: May 2024

Background::
Some drugs cause tongue disorders as adverse effects. Most of the druginduced
tongue disorders are benign and will resolve after drug discontinuation. However, the
changes in the color or appearance of the tongue may frighten patients and decrease compliance
with drug therapy.

Objective::
To review the literature to find all reports of drug-induced tongue disorders, their
presentation, management, and outcome of patients

Methods::
The search was conducted in Google Scholar and PubMed using key words “ageusia,”
“burning tongue,” “coated tongue,” “drug-induced taste disturbances,” “dysgeusia,” “glossitis,”
“glossodynia," “hairy tongue,” “hypogeusia,” “stomatodynia,” “stomatopyrosis,” “swollen
tongue” “tongue discoloration,” “tongue irritation,” “tongue numbness, “tongue oedema,” and
“tongue ulcer. All reports that were published from 1980 to 2022 in the English language were
included in the study. Reports that were not in English language but had English abstracts with
adequate data for extraction were also included.

Results::
A total of 208 case reports and case series were included. The most reported drug classes
were antineoplastic and immunomodulating agents and anti-infectives for systemic use, and
the most common tongue disorders were tongue discoloration and black hairy tongue. Having
good oral hygiene and discontinuing the offending drug could manage and resolve the problem.

Conclusion::
Drug-induced tongue disorders are not rare adverse drug reactions. They are benign
in most cases, and withholding offending agents results in significant improvement or complete
resolution of tongue lesions.