bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diabetes-Induced Vascular Dysfunction and Stemness Decline Investigated via Transcription Factor-Driven Genetic Switches
Authors: Shafi Ovais , Irfan Saba , Ahmed Aelia , Maheshwari Ganpat , Kumar Rajesh , Raveena  , Rajpar Rahimeen , Saeed Ayesha 
Published: May 2024

Abstract

Background:Diabetes mellitus precipitates cardiovascular complications through hyperglycemia, oxidative stress, and inflammation, disrupting vascular cell function. This dysfunction involves altered regulation of transcription factors like Nrf2 and FOXP1, leading to endothelial dysfunction, impaired angiogenesis, and faulty vascular remodeling. Additionally, diabetes reduces the stemness of vascular progenitor cells, hampering vascular repair and homeostasis. Understanding these mechanisms is crucial for identifying therapeutic targets to mitigate diabetic vascular complications.Methods:Databases, including PubMed, MEDLINE, Google Scholar, and open access/subscription-based journals were searched for published articles without any date restrictions, to investigate the diabetes-induced vascular dysfunction and stemness decline through the lens of vascular transcription factor-driven genetic switches. Based on the criteria mentioned in the methods section, studies were systematically reviewed to investigate how diabetes harms vascular cells. This study adheres to relevant PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses).Results:This study reveals significant dysregulation of key transcription factors including Nrf2, FOXP1, SMAD, PAX3/7, and GATA in diabetes, leading to compromised oxidative stress responses and increased inflammatory signaling in vascular cells. In endothelial cells, impaired function of these factors resulted in decreased nitric oxide production and increased endothelial permeability. Additionally, altered FOXP1 and GATA activity exacerbated vascular inflammation. In VSMCs, diabetes-induced transcription factor dysregulation promoted a shift from a contractile to a synthetic phenotype, characterized by increased proliferation and matrix production, contributing to vascular stiffness and atherosclerosis. The stemness of vascular progenitor cells was notably reduced, affecting their differentiation capabilities and exacerbating vascular complications in diabetic conditions.Conclusion:Diabetes impairs vascular health by disrupting key transcription factors and signaling pathways, leading to endothelial dysfunction, abnormal vascular remodeling, and a decline in stemness of vascular cells. Dysregulated factors like Nrf2, FOXP1, and GATA contribute to reduced nitric oxide production, increased vascular permeability, and enhanced inflammation, exacerbating atherosclerosis and hypertension. Addressing these dysfunctions through targeted therapies that enhance transcription factor activity and modulate signaling pathways may mitigate diabetes-related vascular complications. Further research is essential for developing effective interventions to restore vascular homeostasis in diabetic patients.
Long-term water quality variations and influencing factors in Dianchi Lake, China – Insights from 30-year data
Authors: Shen Moyu , Liao Anran , Pan Min , Chen Zhuo , Lu Yun , Tao Yi 
Published: May 2024

ABSTRACT

Changes in water quality in Dianchi Lake over a long temporal scale have been significantly influenced by climate change and policy issuance. This study utilized the Mann -Kendall test and Theil -Sen estimation to examine water quality trends at 10 monitoring sites within Dianchi Lake from 1989 to 2018. The corresponding impacts of policies, including point source (PS) and non-point source (NPS) pollution control, ecological restoration (ER), and enforcement and supervision (ES), along with climatic conditions, were evaluated. Analysis of regression curves of water quality indexes indicates a slight increase in ammonia (NH4+-N) and total nitrogen (TN), while total phosphorus (TP), biochemical oxygen demand (BOD5), permanganate index (CODMn), and chlorophyll-a (Chl-a) decreased from the baseline time (year 1989). During the mid-phase (2001 -2006) of the study period, the impacts of policies on water quality were inconspicuous, with water temperature affecting Chl-a concentration variations. During the 11th Five-Year Plan, pollutants like NH4+-N, TN, TP, and CODMn peaked and then significantly declined between 2009 and 2015, likely due to comprehensive issuance of NPS and ER policies. This study can provide a reference for water quality management in eutrophic lakes.
Assessment of irrigation suitability of water in Hirakud reservoir and Bargarh main canal, Odisha, India: A multivariate analysis
Authors: Ahmed Syed Nikhat , Sahoo Sawan Kumar , Baitharu Iswar 
Published: May 2024

ABSTRACT

The present study assesses the chemical characteristics and irrigation suitability of water in the Hirakud reservoir and main canal. Water samples were collected from 10 different sites during the premonsoon, monsoon, and postmonsoon seasons. The pH, EC, TDS, major ions, and trace metals were estimated using standard methods. The pH of water samples was slightly alkaline in a few sites. The concentration of all the major ions was below the permissible limit except for K+. The concentration of cations and anions in water was in the order of Ca2+ &gt; Na+ &gt;Mg2+ &gt; K+ and HCO3− &gt; Cl− &gt; SO42− &gt; NO3− respectively. Piper's trilinear diagram revealed that water samples were of Mg-HCO3− and mixed type. A strong correlation of Cl– with other ions suggested precipitation dominance in the hydrogeochemistry of water. The concentration of all trace metals in water samples was above the permissible limit across the season. Although reservoir water was of excellent category as per EC and SAR, RSC remained above the limit across the season. PCA suggested that anthropogenic and geogenic processes regulate water quality in the reservoir. The present work provides a baseline for water quality management policy for the Hirakud reservoir as well as the command area.
Screening for Hypertension in Adults of a Northern Delta Province in Vietnam
Authors: Van Minh Huynh , Bich Thuy Le Thi , Tu Nguyen Tran , Van Sang Phan , Bạch Yen Hoang  Thị , Anh Tien Hoang 
Published: May 2024

Background:
The proportion of people with hypertension is increasing, and those affected
are relatively younger. Worldwide, it is estimated that people with high blood pressure are
more than 1.5 billion people. In Vietnam, from 2002 to 2008, according to a national survey on hypertension
and its risk factors within the prevention and control of cardiovascular disease program,
the prevalence of hypertension was 25.1%. This is alarming because high blood pressure
can cause serious complications, including death.

Objective:
The study aimed to explore the blood pressure characteristics and hypertension prevalence
in adults in a northern delta province of Vietnam, and describe some risk factors in hypertensive
subjects screened through the program.

Methods:
This was a cross-sectional study collecting data from people aged 18 years or older in
10 cantons and the city of Nam Dinh from July 15th to July 31st, 2020. Using semi-automatic OMRON
sphygmomanometers, sitting blood pressure was measured three times according to standardized
methods specified by the Ministry of Health and two National Vascular Societies.

Results:
Blood pressure screening of 183,632 adults included 84,438 males, which accounted for
45.98%, with an average age of 60.36 ± 13.18 years. The estimated prevalence of hypertension
was 27.20% (95% CI: 27.00% - 27.41%). The older the age, the higher the rate of hypertension in
both sexes; the prevalence of hypertension over 65 years was 45.36%. Hypertension grade 1 accounted
for 17.14%, followed by hypertension at grade 2 at 6.69%, and grade 3 at 1.15%; notably,
the percentage of prehypertension accounted for 49.64%. The percentage of treated hypertension
in Nam Dinh province was 56.85%, but the percentage of uncontrolled hypertension was 85.63%.

Conclusion:
The prevalence of hypertension in Nam Dinh province was relatively high (27.20%),
although the number of treated patients was also high (56.85%); moreover, the proportion of uncontrolled
hypertension remained extremely high (85.63%). Local campaigns and suitable interventions
are required to detect hypertension in the early stages and increase awareness for treatment
in the population.
Strategies to Enhance Ocular Penetration of Drugs in Controlled Release
Formulations
Authors: Singh Devesh , Kumar Mishra Akhilesh , Mishra Khushboo , Chanchal Dilip Kumar , Singh Chaudhary Jitendra 
Published: May 2024

Objective::
The purpose of this study is to provide a thorough examination of methods for
improving ocular medication penetration within controlled-release formulations, with an emphasis
on their relevance to the treatment of eye disorders.

Method::
Employing a methodical and rigorous methodology, this study provides an in-depth survey
of current knowledge and research on the topic. Research on iontophoresis, prodrugs, pH modulation,
penetration enhancers, hydrogels, inserts, nanomicelles, microemulsions, dendrimers, contact lenses,
cationic emulsions, and targeted drug delivery are only some of the many topics covered in this study.

Results::
Results summarise and synthesize prior research to give useful insights into the efficacy and
potential of controlled-release formulations in increasing ocular medication delivery, providing a
thorough review of current insights into these techniques.

Discussion::
The discussion portion of the review critically assesses the guiding principles, advantages,
and downsides of each technique, and it also investigates the consequences and prospects
for this developing subject.

Conclusion::
The study highlights the revolutionary potential of controlled-release formulations in
the treatment of ocular illnesses, highlighting the importance of overcoming the obstacles associated
with restricted pharmaceutical penetration into ocular tissues. This study concludes the present level
of knowledge and paves the way for future improvements in the area of ocular medication administration,
making it an essential resource for scientists and medical professionals working on the subject.
EVALUASI PERAN GURU PRODUKTIF OTOMOTIF DALAM PROSES PEMBELAJARAN JARAK JAUH (PJJ) MELALUI GOOGLE CLASSROOM
Authors: Suyitno Suyitno 
Published: May 2024

Penelitian ini bertujuan untuk mengetahui hasil evaluasi peran guru produktif otomotif dalam perencanaan, pelaksanaan, dan penilaian Pembelajaran Jarak Jauh (PJJ) melalui google classroom di SMK Negeri 1 Ambal tahun pelajaran 2020/2021. Jenis penelitian ini adalah Penelitian Deskriptif Kuantitatif. Subyek penelitian tindakan adalah guru otomotif di SMK Negeri 1 Ambal yang berjumlah 11. Instrumen yang digunakan dalam penelitian yaitu lembar observasi kuisioner evaluasi peran guru dalam proses pembelajaran jarak jauh melalui google classroom. Analisis data dengan analisis kuantitatif untuk mencari presentase hasil pembelajaran melalui google classroom. Hasil penelitian ini adalah, bahwa peran guru dalam proses pembelajaran jarak jauh melalui google classroom efektif digunakan pada masa pandemi. Hal ini terlihat dari 11 guru produktif otomotif di SMK Negeri 1 Ambal mempunyai administrasi pembelajaran yang lengkap dan dibuat sebelum melaksanakan Pembelajaran Jarak Jauh (PJJ) melalui google classroom. Hasil evaluasi peran guru produktif otomotif dalam perencanaan Pembelajaran Jarak Jauh (PJJ) melalu google classroom di SMK Negeri 1 Ambal tahun pelajaran 2021/2022 memiliki rata-rata nilai evaluasi pelaksanaan pembelajaran 86 dengan kategori baik. Hasil evaluasi peran guru produktif otomotif dalam pelaksanaan Pembelajaran Jarak Jauh (PJJ) melalui google classroom di SMK Negeri 1 Ambal tahun pelajaran 2021/2022 memiliki rata-rata nilai evaluasi pelaksanaan pembelajaran 83 dengan kategori baik. Hasil evaluasi peran guru produktif otomotif dalam penilaian Pembelajaran Jarak Jauh (PJJ) melalu google classroom di SMK NEGRI 1 Ambal tahun pelajaran 2021/2022 memiliki rata-rata nilai evaluasi pelaksanaan pembelajaran 75 dengan kategori cukup.
Examining the Emotional and Physical Health Impact in Users of Open-Source Automated Insulin Delivery and Sources of Support: Qualitative Analysis of Patient Narratives
Authors: Cleal Bryan , Chen Yanbing , Wäldchen Mandy , Ballhausen Hanne , Cooper Drew , O'Donnell Shane , Knoll Christine , Krug Niklas , Raile Klemens , Ubben Tebbe , Tappe Adrian , Lewis Dana , Willaing Ingrid , Skinner Timothy , Braune Katarina 
Published: May 2024

Background
Although commercially developed automated insulin delivery (AID) systems have recently been approved and become available in a limited number of countries, they are not universally available, accessible, or affordable. Therefore, open-source AID systems, cocreated by an online community of people with diabetes and their families behind the hashtag #WeAreNotWaiting, have become increasingly popular.

Objective
This study focused on examining the lived experiences, physical and emotional health implications of people with diabetes following the initiation of open-source AID systems, their perceived challenges, and their sources of support, which have not been explored in the existing literature.

Methods
We collected data from 383 participants across 29 countries through 2 sets of open-ended questions in a web-based survey on their experience of building and using open-source AID systems. Narratives were thematically analyzed, and a coding framework was identified through iterative alignment.

Results
Participants consistently reported improvements in glycemia, physical health, sleep quality, emotional impact on everyday life, and quality of life. Knowledge of open-source AID systems was largely obtained through the #WeAreNotWaiting community, which was also the primary source of practical and emotional support. The acquisition of the components to build an open-source AID system and the technical setup were sometimes problematic.

Conclusions
The #WeAreNotWaiting movement represents a primary example of how informed and connected patients proactively address their unmet needs, provide peer support to each other, and obtain results through impactful, user-driven solutions. Alongside providing evidence on the safety and efficacy of open-source AID systems, this qualitative analysis helps in understanding how patients’ experiences and benefits range from psychosocial improvements to a reduction in the burden of managing diabetes.

International Registered Report Identifier (IRRID)
RR2-10.2196/15368
Does Unconditional Accounting Conservatism Imply Upside or Downside Risk? Evidence from the Options Market
Authors: Kale Devendra , Villupuram Sriram V. 
Published: May 2024

SYNOPSIS
Conservatism captures an asymmetric reporting practice in response to uncertainty in business operations (earnings). Such uncertainty in business operations implies that investors are exposed to tail risk such that there is a probability of large earnings growth, offset by the probability of a large earnings decline. Existing literature has shown that accounting conservatism relates positively to stock returns. However, the literature is silent on whether this pricing is driven by positive earnings expectation or by the potential negative earnings growth. Using option-implied assets, we find that conservatism is priced by investors’ risk aversion (downside risk) rather than the potential upside. Several robustness tests confirm the findings. We also provide evidence that the returns are not driven by mispricing but as compensation for the risk implied by conservative reporting. We further decompose an alternate conservatism measure and find that our results are driven by the uncertainty in expenses rather than revenues.
Protocol for assessing invasive plant populations
Authors: Сенатор С.А. , Виноградова Ю.К. 
Published: May 2024

Впервые в русскоязычной литературе приводится протокол оценки состояния попу- ляций инвазионных видов растений, представленный в виде бланка описания. Его разработка и применение являются важными шагами на пути к систематическому документированию ин- формации об инвазионных видах растений на региональном, национальном или международном уровне. Созданный протокол учитывает основные критерии, использующиеся для комплексной оценки воздействия: экологическое воздействие, ареал, скорость распространения и сложность управления. Приводится дополнительная информация, которую можно учитывать при исследо- ваниях на транспортных магистралях, в интродукционных учреждениях, частных участках и на особо охраняемых природных территориях (ООПТ). Приведены примеры использования прото- кола при инвентаризации инвазионных видов растений вдоль Транссибирской железнодорожной магистрали, в Главном ботаническим саду им. Н.В. Цицина РАН (Москва, Россия). Применение предлагаемого протокола позволит: 1) создать единую систему мониторинга инвазионных рас- тений, 2) разработать общие подходы и критерии к оценке риска, причиняемого инвазионными растениями, 3) унифицировать информацию, полученную при использовании протокола оценки популяций инвазионных видов, которая окажется потенциально применимой в организациях с различной ведомственной принадлежностью.
In Russian studies, a protocol for assessing the state of populations of invasive plant species is presented for the first time as a description form. Its development and application are important steps in systematic documentation of invasive plant species findings at the regional, national, or international level. The protocol takes account of the main criteria used for a comprehensive impact assessment: environmental impact, species distribution rate, and management complexity. The protocol comprises some additional information to be considered in the studies implemented at transport routes, in introduction institutions, agriculture, and protected areas (SPNAs). We provide the examples of the protocol application in the invasive plant species inventory along the Trans-Siberian Railway (Siberia, Russia) and in the Tsitsin Main Botanical Garden of the Russian Academy of Sciences (Moscow, Russia). The application of the proposed protocol will allow (1) to create the unified system for invasive plant monitoring, (2) to develop the general approaches and criteria for assessing the risk caused by invasive plants, and (3) to unify the data on the protocol application in assessing invasive species populations for their further use by different stakeholders.
Macrophytobenthos stock in the protected water areas of Sevastopol city
Authors: Миронова Н.В. , Панкеева Т.В. 
Published: May 2024

Впервые рассчитаны запасы донной растительности памятников природы г. Сева- стополя на основе проведенных гидроботанических исследований (2020‑2021 гг.). Показано, что наибольшие общие запасы макрофитов и входящих в их состав доминирующих Ericaria crinita, Gongolaria barbata характерны для акватории памятника природы «Прибрежный аквальный ком- плекс (ПАК) у мыса Лукулл», наименьшие ‑ для «ПАК у мыса Сарыч». Максимальный запас фи- томассы Phyllophora crispa отмечен в акватории памятника природы «ПАК у Херсонеса Тавриче- ского». Полученные результаты могут быть рекомендованы для оптимизации природоохранного режима памятников природы.
For the first time, the stocks of bottom vegetation at the natural monuments of Sevastopol city were assessed on the basis of hydrobiological studies (2020–2021). The largest total macrophyte stock and their dominant species (Ericaria crinita and Gongolaria barbata) are typical for the water area of the natural monument “Nearshore Aquatic Complex (NAC) at Cape Lucullus”, the lowest, for “NAC at Cape Sarych”. Maximum biomass stock of Phyllophora crispa algae was recorded in the waters of the natural monument “NAC at Tauric Chersonese”. The results obtained may be recommended for optimizing the environmental regime of the natural monuments.
On establishment of biological (zoological) reserves for conservation of aquatic biological resources and their habitat in the Sheksna and Rybinsk reservoirs
Authors: Коновалов А.Ф. , Борисов М.Я. , Филоненко И.В. , Сельцова С.И. 
Published: May 2024

В акватории Шекснинского и Рыбинского водохранилищ в границах Вологодской области организованы новые особо охраняемые природные территории (ООПТ) регионального значения: государственные биологические (зоологические) заказники «Нерестилища Белозерья» и «Раменье». В акватории обоих заказников в весенне-летний период концентрируются произ- водители и молодь фитофильных видов рыб: леща, щуки, окуня, плотвы, густеры и др., доля которых по численности в уловах ставными сетями составляет 81–85% (заказник «Нерестилища Белозерья») и 81–96% (заказник «Раменье»). Площадь участков с растительностью, заливаемых в период весеннего половодья, представляющих собой важнейшие нерестилища фитофильных видов рыб, в заказнике «Нерестилища Белозерья» составляет около 37.5 км2, или порядка 29.8% от общей площади ООПТ, а в заказнике «Раменье» – 34.8 км2 и 23.4% соответственно. С учетом локализации нерестовых субстратов внесены корректировки в окончательный вариант границ двух ООПТ и разработаны ограничения хозяйственной и иной деятельности.
New specially protected natural areas (SPNAs) of regional significance, i.e. state biological (zoological) reserves “Spawning Grounds of Belozerye” and “Ramenye”, have been established in waters of the Sheksna and Rybinsk reservoirs located within the boundaries of Vologda Oblast. In waters of both reserves, producers and the young of phytophilous fish (bream, pike, perch, roach, silver bream, etc.) are concentrated in the spring-summer period. Their share in catches implemented with fixed nets makes up 81–85% (“Spawning Grounds of Belozerye”) and 81–96% (“Ramenye”). The area of flooded in spring overgrown sites, which are major spawning grounds for phytophilous fish species, reaches about 37.5 km2, or 29.8% of the total protected area in the “Spawning Grounds of Belozerye” and 34.8 km2, or 23.4% – in the “Ramenye” reserve. Taking into account the localization of spawning substrates, the boundaries of both SPNAs have been adjusted with further development of restrictions to be imposed on economic and other activities.
Formation of a life strategy in plant species from technogenic ecotopes by the example of short-rhizomatous Orchids
Authors: Егорова Н.Ю. , Сулейманова В.Н. 
Published: May 2024

На примере коротко-корневищных орхидей Epipactis atrorubens, E. helleborine, Neottia ovata и Cypripedium calceolus показаны результаты анализа жизненной стратегии видов рас- тений в измененных биотопах. В 2020–2022 гг. проанализировано 16 ценопопуляций орхидей на зарастающем деревьями не восстановленном карбонатном карьере. Показано, что рассматри- ваемые виды растут в лесных и лесо-луговых сообществах. Среди сосудистых растений изучен- ных фитоценозов преобладают луговые и лугово-опушечные виды. У рассматриваемых орхидей наблюдаются две стратегии развития, которые отличаются последовательностью защитных и стрессовых элементов. Морфометрические параметры почти всех изученных видов проявляют дивергентно-конвергентные или конвергентно-дивергентные тактики.
The paper presents the results of the analysis of a life strategy formation in plant species under conditions of anthropogenically transformed ecosystems by the example of short-rhizomatous orchids: Epipactis atrorubens, Epipactis helleborine, Neottia ovata, and Cypripedium calceolus. In 2020–2022, 16 cenopopulations of the studied species from a non-reclaimed limestone quarry overgrown with trees were examined. These species grow in forest communities and forest-meadow ecotone biotopes in the technogenic environment. Vascular plants of the studied phytocenoses, meadow and meadow-edge species dominate. Representatives of the family Orchidaceae have two types of ontogenetic strategies distinguished by the alternation of protective and stress components. Morphobiological parameters almost in all taxa exhibit mixed types of tactics: divergent-convergent and convergent-divergent.