bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meningioma as a Rare Presentation
Authors: Almumen Mais , Muslim Liqaa Mohammed , Rasheed Ammar Saeed 
Published: June 2024

Background: The most common extra axial primary central nervous system (CNS) tumor is meningioma, accounting for 36% of all CNS tumors. On neuroradiologic and gross assessment, the typical meningioma is lobulated. Cystic variants, although uncommon, are well recognized, and possibly be confused with metastatic or glial tumors. Case presentation: A 40-year-old female patient complaining of headache, Magnetic resonance imaging (MRI) revealed frontoparietal brain cystic lesion with intracystic nodule, given the differential diagnosis of low-grade gliomas, hemangioblastoma, pleomorphic xanthoastrocytoma, pilocytic astrocytoma and rarely meningioma. The histopathological slides showed the diagnosis of meningothelial meningioma (WHO/Mayo Clinic_ Grade I). Immunohistochemistry (IHC) was performed for epithelial membrane antigen (EMA) showing positive membranous stain but IHC staining for glial fibrillary acetic protein (GFAP) was negative for the cytoplasm. Conclusions: Patient with cystic meningioma was reported. There is no absolute test for preoperatively distinguishing it from the most prevalent other gliomas. So avoiding any extra cost and time loss, angiographic assessment and cooperation with a histopathologist are of clinical importance for the identification of these possibly curable neoplasms.
The Sensitivity and Specificity of Measuring the Thickness of Myometrium to Predict the Time of Spontaneous Labour in Preterm Prelabor Rupture of Membranes and Oligohydramnios
Authors: Zeiny Luma 
Published: June 2024

Background: Preterm prelabour rupture of membranes (PPROM) accounts for one- third of cases of preterm labour which is the leading cause of perinatal morbidity and mortality. The time from the rupture of membranes until labour, i.e. the latent period (LP), is an important factor in neonatal outcome. Aim of the study: The present study aims to determine the sensitivity and specificity of measuring the thickness of myometrium for the prediction of LP. Patients and methods: This cross-sectional observational study was performed in Az-Zahraa Teaching Hospital in Najaf-Iraq during the period from the first of August 2016 to the first of October 2017. A total of 89 patients who admitted with the diagnosis of PPROM at the 26th to the 34th weeks of gestation with oligohydramnios were included in the study. The thickness of myometrium was measured via transabdominal ultrasound in the lower uterine segment (LSMT), anterior (AMT), posterior (PMT) and fundal (FMT) parts of uterus within 24 hours of membranes rupture. Results: The mean measurements of LSMT, AMT, PMT and FMT in patients with PPROM and oligohydramnios were 7.25±2.31, 7.87±3.45, 8.71±3.88 and 8.65±3.72 respectively. The sensitivity and specificity of measuring AMT for prediction of LP > 7 days were 80% and 53%; those for PFT were 80% and 34.1% respectively at a cut-off point of 6.5 mm while the FMT was found to be 60% sensitive and 34.1% specific. LSMT was 80% sensitive and 43.9% specific for recognition of LP > 7 days at a cut-off point of 7.5mm. Conclusions: measurement of the thickness of the myometrium may be a sensitive but non-specific tool for the prediction of the latent period.
M Multi-Organ Histopathological Changes in SARS COV2 Infection: A Systematic Review and Meta-analysis
Authors: Al-Haboobi Maream Mohammed Ali , Rihab Hameed Al-Mudhafar  
Published: June 2024

Background: The World Health Organization has officially acknowledged the emergence of Coronavirus Disease 2019 (COVID-19), attributed to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, as a rapidly escalating global public health issue and declared it a pandemic. SARS-CoV-2 infection can lead to varied and multiorgan pathologies, with the most notable impacts occurring in the lungs (characterized by phases of diffuse alveolar damage, microthrombi, and bronchopneumonia), heart (involving lymphocytic myocarditis), kidney (resulting in acute tubular injury), and vasculature (involving microthrombi and deep vein thrombi). Objectives: To summarize, resolve contradiction and provide solid evidence on multiorgan histopathological changes caused by SARS-CoV2 infection. Material and method: Histological data obtained from autopsy and biopsy studies were gathered following the guidelines of the Preferred Reporting Items for Systematic Review (PRISMA). An extensive electronic search was conducted on databases such as PubMed, Science Direct, Scopus, and Google Scholar, covering the period from database inception to March 2022. The collected studies underwent a systematic literature search, and a thorough critical review was performed. Result: After excluding studies that did not meet the eligibility criteria, a total of 58 articles were included in the review. We estimate the histopathological findings of 13 organ. For the pool proportion of exudative, proliferative and fibrotic phase of diffuse alveolar damage of lung is (70.666%, 56.126% and 33.031%) respectively. For liver steotosis is 35.808%. For acute tubular injury of kidney is 74.872%. For adrenal cortical necrosis is 13.113%. For brain gliosis is 13.865%. For heart necrosis is 5.477%. For gastrointestinal tract the pool proportion of inflammatory cells infiltration is 6.171%. For placental infarction is 25.684%. For orchitis is 29.019%. For perivascular inflammation of skin is 35.176%. For lymphocytic depletion of white pulp of spleen is 69.204%. For hemophagiocytosis of lymph node is 7.022%. For bone marrow fibrosis is 8.473%. Conclusion: COVID-19 is characterized as a multiorgan infection closely associated with a hyperinflammatory state, believed to initiate with diffuse alveolar damage and immuno-thrombotic microangiopathy. The extensive activation of the immune system and microvascular damage may contribute to indirect harm to other organs, although the direct impact of the virus on these tissues cannot be ruled out.
Admission Pattern and Treatment Outcome in Pediatric Intensive Care Unit in Al Zahraa Teaching Hospital, Iraq, Najaf
Authors: Neam Arkan Mohsen  , Alaa Jumaah Manji Nasrawi  
Published: June 2024

Background: The Pediatric Intensive Care Unit (PICU) represents a specialized healthcare setting dedicated to providing critical care for infants, children, and adolescents facing severe and life-threatening medical conditions. The rate of pediatric mortality in the Pediatric Intensive Care Unit (PICU) varies worldwide, reflecting the diverse healthcare landscapes and socioeconomic factors influencing pediatric critical care outcomes. The objective of this study was to describe the pattern of admission and outcome of patients who received intensive care. Patients and Methods: A retrospective study in which records of admissions (from 1st of January 2019 to 31 December 2023) were obtained from the PICU patient's file in Al Zahraa Teaching, Najaf, Iraq. Data used from the records included age, sex, residency, address, source of admission, diagnosis, duration of stay in the unit, need for intubation and mechanical ventilation, and patient outcome.
Results: A total number of 1501 patients were admitted to the PICU during the study period. The patients were referred mainly from the Emergency Room 47% followed by the neonatal intensive care unit 21%. The case fatality rate was 54.1%. the main cause of death was RDS, sepsis, meningitis, and congenital heart diseases (29.2, 8.5, 6.6, and 6.6% respectively). 47.9% of PICU deaths occurred in patients admitted from the ER followed by NICU 24.2%. (P value 0.043, OR 1.082, 95% CI 1.002-1.168). The mean age of dead PICU patients was 15.697±32.79 months versus 23.301±39.91 months for discharged outcome (P value 0.000). Hospital stay length mean for PICU dead patients was 5.1±3.8 days versus 6.173±3.8 days for discharged patients (P value 0.000). That means the smaller age patients carry a higher risk of death in PICU, also the situation with fewer hospital stays days. Conclusion: In conclusion, this study showed the case fatality rate was high (54.7%.). The most common causes of admission and death were RDS (22.7% and 29.2% respectively). The highest percentage of death occurs in the infant age group (78.1%). Neither gender nor residency represents a risk factor for PICU patient's death but endotracheal intubation does. The fewer days of hospital stay carry a higher risk factor for death.
Pengawasan Kinerja Kepala Dusun (Datuk Rio) oleh Badan Permusyawaratan Dusun (BPD) Tahun 2022 (Studi: Pemerintahan Dusun Perenti Luweh Kecamatan. Tanah Tumbuh, Kabupaten Bungo)
Authors: Harpisyah Harpisyah , Ridwan Ridwan , Juwita Eva 
Published: June 2024

Lokasi penelitian ini dilaksanakan di di Dusun Perenti Luweh Kecamatan Tanah Tumbuh Kabupaten Bungo. Penelitian ini dilaksanakan 05 April 2023. Penelitian bertujuan untuk mengetahui mengetahui pengawasan kinerja Kepala Desa Perenti Luweh yang dilakukan oleh Badan Permusyawaratan Dusun (BPD) pada Instrumen Pengawasan Kegiatan Pelaksanaan Non-APBDus Tahun 2022 serta Untuk mengetahui pengawasan kinerja Kepala Desa Perenti Luweh yang dilakukan oleh Badan Permusyawaratan Dusun (BPD) pada Instrumen Pengawasan Kegiatan Pelaksanaan Non-APBDus Tahun 2022. Penelitian ini menggunakan metode kualitatif. Hasil penelitian menunjukkan bahwa Pengawasan kinerja Kepala Dusun Perenti Luweh yang dilakukan oleh Badan Permusyawaratan Dusun (BPD) pada Instrumen Pengawasan Kegiatan Pelaksanaan Non-APBDus yaitu melalui melalui tiga tahapan diantaranya (a). Pengawasan dalam Perencanaan kegiatan Pemerintah Dusun, (b) Pengawasan Dalam Pelaksanaan Kegiatan Pemerintah Dusun, (c) Pengawasan Dalam Pelaporan Pertangungjawaban. Faktor penghambat dalam pengawasan kinerja Rio Dusun Perenti Luweh yang dilakukan oleh Badan Permusyawaratan Desa (BPD) adalah sebagai berikut: (a) Tidak adanya mekanisme didalam melakukan pengawasan, (b) Kurangnya Pengawasan terhadap setiap tindakan kepala desa dalam pelaksanaan maupun dalam Pelaporan, (c) Kurangnya tingkat pemahaman anggota BPD dalam pengawasan. (d) Kurangnya kerjasama antara BPD dengan pemerintah Desa
CONTRIBUIÇÕES DO CIRURGIÃO-DENTISTA EM AMBIENTE HOSPITALAR: UMA REVISÃO DE LETERATURA
Authors: Costa da Silva Fraila Ariele , De Carvalho Sousa Isabel Cristina , Vieira Corrêa Aline Emenuele , Damasceno de Sena Lima Eduarda , De Sousa Reis Liana Roberta , Vasconcelos Silva Nikoly Mariana , Da Silva Morais Samaya , Maciel dos Santos Lunna Pietra , Suassuna Torres João Yves , Gonçalves Moreira Thiago Henrique 
Published: June 2024

Introdução: A literatura científica apresenta um número razoável de estudos que reforçam a necessidade da Odontologia Hospitalar. Entretanto, ainda são poucos os que abordam a inserção do Cirurgião-dentista no âmbito hospitalar. Objetivo: Descrever as evidências científicas sobre as contribuições do cirurgião-dentista no ambiente hospitalar. Métodos: Revisão integrativa da literatura, realizada em cinco bases de dados e uma literatura cinzenta, respectivamente: LILACS, BDENF, BBO, MEDLINE, Scopus e Google Scholar. A busca eletrônica foi realizada no dia 04 de junho de 2024. Os critérios de inclusão foram estudos com objeto específico sobre a assistência do cirurgião-dentista no contexto do ambiente hospitalar, com recorte temporal de 10 anos e sem filtro de idioma. Resultados: Foram avaliados 17 artigos, a maioria publicado no ano de 2014 e 2018, no Brasil e com delineamento transversal. Acerca das contribuições do Cirurgião-dentista, destacam-se três cenários, o da Unidade de Terapia Intensiva (UTI), o geral da instituição hospitalar e o cirúrgico. A contribuições no contexto de UTI mais pontuada nos estudos é sobre a prevenção e redução de Infecção Relacionada à Assistência a Saúde (IRAS), principalmente, da incidência de Pneumonia Associada à Ventilação Mecânica. No contexto geral, o Cirurgião-dentista atua em todos os espaços de internação na realização de interconsulta; prevenção, diagnóstico e terapêutica de problemas bucais. No contexto cirúrgico, destacam-se os cuidados com a higiene bucal no pré-operatório e pós-operatória para a prevenção de complicações das cirurgias. Conclusão: A maioria dos estudos versa sobre a atuação do Cirurgião-dentista na UTI, poucos estudos abordam as ações desse profissional no cenário hospitalar geral e operatório.
ASPECTOS CLÍNICOS E EPIDEMIOLÓGICOS DO TRANSTORNO AFETIVO BIPOLAR
Authors: Soares Isadora Veras Araújo , Medeiros Pedro Augusto Cirilo de , Batista Arianne Pires Nunes , Tomaz Gustavo Coutinho , Oliveira Thayne de Fátima Pierre Freitas , Vidal Laura de Sousa Lopes , Ribeiro Hilton Carlos 
Published: June 2024

Apresenta-se uma revisão integrativa de literatura acerca do transtorno afetivo bipolar (TAB), seus aspectos clínicos, epidemiológicos, bem como o impacto dessa condição na vida do indivíduo. Essa condição caracteriza-se como um transtorno de humor que causa alterações comportamentais repentinas, recorrentes, crônicas e graves. Há alterações de humor que vão do estado de depressão profunda à euforia extrema. É um transtorno que apresenta episódios maníacos ou hipomaníacos separados por períodos de normalidade, além de poder apresentar delírios, alucinações, em padrão sazonal, que podem levar ao acometimento temporário de suas funções cognitivas, comportamentais e afetivas. Utilizam-se critérios diagnósticos para definir o quadro, que pode coexistir com outras comorbidades. Há necessidade de uma equipe multidisciplinar para intervir na melhoria e na qualidade de vida dos pacientes, assim como um tratamento voltado para os vários aspectos que esse transtorno apresenta.
DERMATITE ATÓPICA: INCIDÊNCIA, CAUSAS E TRATAMENTO
Authors: Ticianel Yasmin Ahmad , Marques Daiana Rossi Lima , Diniz Deisy Comunello , Damasceno Isadora Lessa Silva , Bonato Jonas Felipe , Wunsch Bruno Schwanz , Nemitz Caroline da Silva , Santos Ariele Cristina Souza , Coelho Sabrina Fernanda Figueiredo , Carvalho Breno Ferraz de , Ruiz Melissa Safariz , Clementele Lilian Fonseca , Assis Patrícia Balbi de , Silva Maria Clara Pessoa da , Melo Beatriz Brandão de , Souza Guilherme Rodrigues da Costa , Henrique Sandy Hevelyn Araujo , Flores Kevillyn Maria Nava , Oliveira Beatriz Pessoa Cardoso 
Published: June 2024

A dermatite atópica (DA) é uma doença inflamatória cutânea crônica de etiologia multifatorial incluindo fatores genéticos. Essa patologia leva a alterações na barreira cutânea e imunológicas expressada sob a forma de eczema, caracterizada pele seca com prurido constante o que leva a ferimentos. Este estudo tem como objetivo discorrer os pontos importantes sobre a incidência da dermatite atópica.
Caracterización de Síndrome Confusional Agudo en un Hospital de 2do Nivel: Incidencia y Etiologías Comunes
Authors: Ramírez Galindo María del Rayo , Basurto Pérez María Félix , Torres García Gloria Beatriz , Carbonell Montes Luisa Fernanda 
Published: June 2024

El Síndrome Confusional Agudo es de origen multifactorial, se caracteriza por alteraciones agudas del estado mental, frecuentemente reversible y con fluctuación de los síntomas (alteración de la atención, pensamiento desorganizado y alteración en el estado de alerta). Es un indicador de la calidad de la atención hospitalaria, pues los factores implicados en su desarrollo son prevenibles. Su evaluación en la sala de urgencias ha tomado mayor importancia con el tiempo, ya que esta patología puede ser consecuencia de padecimientos concomitantes cuya identificación y tratamiento son un desafío y requiere un enfoque específico para la determinación de su etiología. Se realizó un estudio prospectivo, descriptivo y observacional en el periodo de un año, con el objetivo de Identificar la incidencia de Síndrome Confusional Agudo y etiologías comunes en pacientes ingresados a urgencias de Hospital General 450; se recabaron 88 pacientes, lo que representa una incidencia de 0.23%; con predominio del sexo masculino (63%), una edad media de 62 años; la comorbilidad más frecuentes fue la hipertensión arterial (42%), con predominio del subtipo hipoactivo (85.2%), y las principales etiologías fueron alteraciones metabólicas (31.8%) y neurológicas (25%). Conclusiones: El deterioro cognitivo es causa importante de ingreso; es necesario establecer pruebas diagnostica de rutina en la práctica clínica.
Pengaruh Kepemimpinan Transformasional dan Kecerdasan Emosional Terhadap Kinerja Guru Gugus III Keude Bate Kabupaten Pidie
Authors: Rohani Rohani , Akmaluddin Akmaluddin , Rahmattullah Rahmattullah 
Published: June 2024

Penelitian ini bertujuan untuk menganalisis pengaruh kepemimpinan transformarional dan kecerdasan emosional terhadap kinerja guru gugus III Keude Bate. Penelitian ini merupakan jenis penelitian kuantitatif. Sampel penelitian ini adalah adalah guru di SDN Gugus III Kabupaten Pidie dengan teknik pengambilan sampel menggunakan teknik purposive sampling. hasil analisis membuktikanbahwa variabel kepemimpinan transformasional berpengaruh signifikan secara parsial terhadap kinerja guru di Gugus III Keude Batee Kabupaten Pidie, variabel kecerdasan emosional berpengaruh signifikan secara parsial terhadap kinerja guru di Gugus III Keude Batee Kabupaten Pidie dan variabel kecerdasan emosional dan kepemimpinan transformasional berpengaruh signifikan secara bersama-sama (simultan) terhadap kinerja guru di Gugus III Keude Batee Kabupaten Pidie.
GLA:D to Be Walking Better: Change in Self-Reported Difficulty Walking After Exercise Therapy and Education in Persons With Knee Osteoarthritis
Authors: King Lauren K. , Young James J. , Grønne Dorte T. , Bricca Alessio , Roos Ewa M. , Skou Søren T. , Hawker Gillian A. 
Published: June 2024

ObjectiveDifficulty walking is a primary reason that individuals with knee osteoarthritis (OA) seek care. We examined the change in self-reported difficulty walking after participating in the Good Life With Osteoarthritis in Denmark (GLA:D) 8-week education and exercise program and assessed patient factors associated with improvement in difficulty walking.MethodsThis was a registry-based cohort study of individuals in Denmark with knee OA who enrolled in GLA:D. Assessments were administered at baseline, program completion (~3 months), and 12 months. Our prespecified primary outcome was change in self-reported difficulty walking assessed using the EuroQol 5-dimension 5-level walking item. Exposures included sociodemographic factors, measures of OA illness severity, comorbidities, and psychological factors. In those with baseline moderate/severe difficulty walking, using multivariable regression analysis, we assessed the relationship between exposures of interest and improvement to no/slight difficulty walking.ResultsWe included 5262 participants. Of 2178 (41.4%) individuals with baseline moderate/severe difficulty walking, 51.4% and 58.3% reported no/slight difficulty walking at 3 and 12 months, respectively. Greater self-efficacy, younger age, female sex, lower BMI, less intense knee pain, and better function at baseline were associated with greater likelihood of improvement in difficulty walking, whereas severe difficulty walking at baseline and back pain intensity were associated with decreased likelihood of improvement.ConclusionMore than half of those with baseline difficulty walking experienced substantial improvement after completing GLA:D and this improvement was maintained at 12 months. Several patient factors were associated with the outcome, suggesting that some individuals may require additional support and extended treatment.
Clinical Validation of Digitally Acquired Clinical Data and Machine Learning Models for Remote Measurement of Psoriasis and Psoriatic Arthritis: A Proof-of-Concept Study
Authors: Webster Dan E. , Haberman Rebecca H. , Perez-Chada Lourdes M. , Tummalacherla Meghasyam , Tediarjo Aryton , Yadav Vijay , Neto Elias Chaibub , MacDuffie Woody , DePhillips Michael , Sieg Eric , Catron Sydney , Grant Carly , Francis Wynona , Nguyen Marina , Yussuff Muibat , Castillo Rochelle L. , Yan Di , Neimann Andrea L. , Reddy Soumya M. , Ogdie Alexis , Kolivras Athanassios , Kellen Michael R. , Mangravite Lara M. , Sieberts Solveig K. , Omberg Larsson , Merola Joseph F. , Scher Jose U. 
Published: June 2024

ObjectivePsoriatic disease remains underdiagnosed and undertreated. We developed and validated a suite of novel, sensor-based smartphone assessments (Psorcast app) that can be self-administered to measure cutaneous and musculoskeletal signs and symptoms of psoriatic disease.MethodsParticipants with psoriasis (PsO) or psoriatic arthritis (PsA) and healthy controls were recruited between June 5, 2019, and November 10, 2021, at 2 academic medical centers. Concordance and accuracy of digital measures and image-based machine learning models were compared to their analogous clinical measures from trained rheumatologists and dermatologists.ResultsOf 104 study participants, 51 (49%) were female and 53 (51%) were male, with a mean age of 42.3 years (SD 12.6). Seventy-nine (76%) participants had PsA, 16 (15.4%) had PsO, and 9 (8.7%) were healthy controls. Digital patient assessment of percent body surface area (BSA) affected with PsO demonstrated very strong concordance (Lin concordance correlation coefficient [CCC] 0.94 [95% CI 0.91-0.96]) with physician-assessed BSA. The in-clinic and remote target plaque physician global assessments showed fair-to-moderate concordance (CCCerythema0.72 [0.59-0.85]; CCCinduration0.72 [0.62-0.82]; CCCscaling0.60 [0.48-0.72]). Machine learning models of hand photos taken by patients accurately identified clinically diagnosed nail PsO with an accuracy of 0.76. The Digital Jar Open assessment categorized physician-assessed upper extremity involvement, considering joint tenderness or enthesitis (AUROC 0.68 [0.47-0.85]).ConclusionThe Psorcast digital assessments achieved significant clinical validity, although they require further validation in larger cohorts before use in evidence-based medicine or clinical trial settings. The smartphone software and analysis pipelines from the Psorcast suite are open source and freely available.
Long-Term Data on Efficacy and Safety of Selexipag for Digital Systemic Sclerosis Vasculopathy
Authors: Di Battista Marco , Della Rossa Alessandra , Mosca Marta 
Published: June 2024

ObjectiveRaynaud phenomenon (RP) and digital ulcers (DUs) are the main signs of digital vasculopathy in systemic sclerosis (SSc). Selexipag is an oral prostacyclin agonist approved for SSc-related pulmonary arterial hypertension. Following our previous preliminary short-course report, we herein present long-term data on selexipag safety and efficacy in the treatment of SSc digital vasculopathy.MethodsSelexipag was administered to patients with SSc with severe digital vasculopathy refractory or with contraindication to all other vasoactive therapies. Each subject was assessed at baseline and after 3, 6, and 12 months. Clinical outcomes related to RP and DUs were evaluated along with modified Rodnan skin score of the fingers. Digital perfusion was assessed by laser speckle contrast analysis (LASCA). Nailfold videocapillaroscopy (NVC) was also performed.ResultsEight patients with SSc (63% female, mean age 50.1 years) received selexipag. After 12 months of treatment, RP was reported to significantly decrease in the number of daily episodes and mean duration (P< 0.001 andP= 0.01, respectively). All patients achieved a complete healing of their DUs (P= 0.03) within 6 months. A progressive reduction of fingers skin score was observed (P= 0.03). No structural changes of capillaries were noted on NVC. Conversely, LASCA revealed an important increase in total digital perfusion (P= 0.004) despite seasonal variability. The safety profile was consistent with that reported in the literature.ConclusionWe observed a sustained efficacy of selexipag on SSc digital vasculopathy during 1 year of administration. Our promising results encourage the design of a new randomized controlled trial to evaluate the effect of selexipag on SSc digital vasculopathy.