bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of WHO 2006 Growth Standards and Synthetic Indian References in Assessing Growth in Normal Children and Children with Growth-Related Disorders
Authors: Dange Nimisha Shankar , Khadilkar Vaman , Kore Vrushali , Mondkar Shruti , Yewale Sushil , Gondhalekar Ketan , Khadilkar Anuradha V 
Published: April 2024

Abstract

Introduction:
A good screening tool, such as a growth chart, should distinguish between children with normal growth and those with perturbed growth. Suitability of synthetic Indian growth references for diagnosing growth-related disorders for under-five children has not been evaluated. To assess the validity of World Health Organization (WHO) 2006 standards vs synthetic Indian references (2019) (by comparing weight, height, body mass index (BMI), standard deviation scores (SDS) and the composite index of anthropometric failure (CIAF)) in differentiating normal children and children with growth-related disorders.

Methods:
Records of 2188 children (0–60 months) attending a tertiary centre paediatric outpatient department (OPD) were retrospectively studied; 1854 children were healthy and 334 were diagnosed with growth-related disorders as per the European Society for Paediatric Endocrinology (ESPE) classification. The anthropometric parameters converted to Z-scores for weight-for-age (WAZ), height-for-age (HAZ), BMI-for-age (BAZ) and a CIAF were computed using WHO and synthetic charts; Student’s t-test was used for assessing differences and Youden’s index for validity.

Results:
Disease status of children and anthropometric failure on WAZ, HAZ, BAZ and CIAF on both WHO and synthetic charts had a significant association (P-value <0.05). WAZ, HAZ on both charts and CIAF on synthetic chart had a fair to moderate agreement (Kappa statistics) with disease status as per diagnosis (P-value <0.05). The sensitivity and negative predictive value for all anthropometric parameters were higher for synthetic charts.

Conclusion:
Indian charts were more sensitive for diagnosing growth-related disorders from birth to 60 months of age when compared to WHO growth standards.
Burden of Goitre and Urinary Iodine Status among Primary School Children in Kashmir, India—Evidence from a Population-Based Iodine Deficiency Disorder Survey
Authors: Qazi Tanzeela B. , Malik Tazean Z. , Khan S Muhammad Salim , Qurieshi Mariya A. , Pandit Mohammad Iqbal , Haq Inaamul , Dkhar Sabira A. , Bashir Khalid , Chowdri Iqra N. , Nabi Sahila 
Published: April 2024

Abstract

Introduction:
Iodine deficiency is the leading cause of preventable brain damage, with 30% of the world’s population suffering from iodine deficiency disorders (IDDs). The objectives of the study are to estimate the prevalence of goitre among schoolchildren in the age group of 6–12 years, to find out the proportion of households with adequately iodised salt, and to assess the dietary iodine intake by measuring urinary iodine levels in the urine samples of school-going children.

Methods:
A cross-sectional study was conducted in four pre-selected districts of the Kashmir division of Jammu and Kashmir in school-going children aged 6 to 12 years. Multi-stage 30 cluster sampling was used to select the study sample. For the selection of 30 clusters in each district, probability proportional to size (PPS) was employed. From each cluster, 90 children were selected. From a sub-sample of children in each district, 540 salt samples and 270 urine samples were also collected.

Results:
A total of 10,800 children aged 6–12 years were examined. Grade I goitre was present in 1382 (12.8%) and 116 (1.07%) which were having Grade II goitre. The weighted prevalence of goitre for four districts was 12.6%, lowest for district Ganderbal and highest for district Shopian. Half of the population in all the districts consumed salt with iodine levels of <15 ppm. Urinary iodine levels <99.9 mg/L were present in 15.7% indicating mild to moderate iodine deficiency.

Conclusion:
Though the present survey showed some decline in the total goitre rate (TGR) from a prevalence of 14.8% in 2017 to 12.6% in 2022, it continues to be a public health problem of mild to moderate intensity in Kashmir. The salt consumed at the household level was inadequately iodised. Hence, efforts in IDD elimination activities need to be scaled up further with emphasis on iodised salt quality control and intensive education at the community level.
Beginners guide to perform perimetry
Authors: Mansoori Tarannum 
Published: April 2024

Background:
Visual field testing is an indispensable part of assessment of glaucoma. Of paramount importance to both the practitioner and the perimetrist is the guidance on how to conduct the test to get the best results and also the interpretation of test results.

Purpose:
To provide procedure instructions useful for operating the Humphrey perimeter and testing the patient by monitoring the live eye monitor.

Synopsis:
Brief overview of how the Humphrey visual field is conducted in an easy to understand manner is presented.

Highlights:
This educational video is a step-by-step guide to prepare and perform Humphrey visual field test with video clips, which would be useful to the practicing ophthalmologist and optometrist, and in training programs.

Video Link:
https://youtu.be/YzEA8lQ9MzQ
Incidence of thromboembolic events in non-small cell lung cancer patients treated with immune checkpoint inhibitors: A systematic review and meta-analysis
Authors: Yang Miaomiao , Cao Hongxin , Wang Congcong , Yu Caiyan , Sun Ping 
Published: April 2024

ABSTRACT
The incidence of thromboembolic events (TEs) in non-small cell lung cancer (NSCLC) patients treated with immune checkpoint inhibitors (ICIs) has rarely been reported. The MEDLINE, EMBASE, and the Cochrane Library databases were searched. The primary outcome was the incidence of TEs, and the secondary outcome was the relationship between TEs and overall survival (OS) following ICI therapy. A subgroup analysis of TE incidents was performed according to the TE type and combination regimens. The I2 statistic was used to determine the heterogeneity, and funnel plots and Egger’s test were used to assess publication bias. A total of 16,602 patients with NSCLC in 63 experimental arms were included in the analysis. The rate of TEs ranged from 0.1% to 13.8%, and the pooled overall incidence of all-grade TEs was 3% (95% confidence interval [CI], 2%–4%). The pooled rate of high-grade TEs was 1% (95% CI, 1%–2%). The venous and arterial TE rates were 3% (95% CI, 2%–4%) and 1% (95% CI, 1%–2%), respectively. Patients who received immunotherapy + chemoradiotherapy had the highest incidence of TEs (7%). The TE pooled rate was higher in patients treated with combined ICIs than in those treated with mono ICIs (4% vs. 2%). The OS was lower in patients with TEs than in those without TEs (hazard ratio, 1.4; 95% CI, 1.02%–1.92%). The incidence of TEs in NSCLC patients treated with ICIs was reasonable. Nonetheless, clinicians must be aware of potential thrombotic complications and treat them promptly.
Local therapy combined with anti-PD-1 immunotherapy for advanced lung adenocarcinoma: A case report
Authors: Wu Na , Yang Xiaoxin , Zhai Yan , Lu Wei 
Published: April 2024

ABSTRACT
Lung adenocarcinoma (LUAD) encompasses all lung epithelial cancers except small-cell lung cancer. Although programmed cell death protein 1 (PD-1) inhibitors, such as pembrolizumab, and other Food and Drug Administration-approved immune checkpoint inhibitors, offer new hope for LUAD treatment, LUAD’s overall efficacy remains limited. Thus, the combination of immunotherapy with other therapeutic approaches has gained widespread attention. Local therapy is an optimal method for treating many advanced unresectable lung cancers. Herein, we present a case of a patient with multiple metastases from LUAD, who attained complete response for more than 3 years until present through local therapy combined with a PD-1 inhibitor.
Analysis of the retraction papers in oncology field from Chinese scholars from 2013 to 2022
Authors: Yang Wenyan , Sun Na , Song Hongwei 
Published: April 2024

ABSTRACT

Objective:
To analyze the characteristics of retracted oncology papers from Chinese scholars and the reasons for retraction.

Methods:
Data on retracted oncology papers from Chinese scholars published from 2013 to 2022 were retrieved from the Retraction Watch database. The retraction number and annual distribution, article types, reasons for retraction, retraction time delay, publishers, and journal characteristics of the retracted papers were analyzed.

Results:
A total of 2695 oncology papers from Chinese scholars published from 2013 to 2022 had been retracted. The majority of these papers were published from 2017 to 2020. In terms of article type, 2538 of the retracted papers were research articles, accounting for 94.17% of the total number of retracted papers. The main reasons for retraction were data, result, and image problems, duplicate publication, paper mills, author- and third-party-related reasons, plagiarism, false reviews, and method errors. The retraction time delay for the retracted papers ranged from 0 to 3582 days (median, 826 days). The retractions mainly occurred within the first 4 years after publication. A total of 77 publishers were involved in the retracted papers. In terms of journal distribution, 394 journals were involved in the retracted papers, of which 368 (93.40%) were included in the SCI database. There were 243 journals with an impact factor of <5 (66.03%).

Conclusion:
In the field of oncology, the annual distribution of retracted papers from Chinese scholars exhibited first an increasing and subsequently a decreasing trend, reaching a peak in 2019, indicating an improvement in the status of retraction after 2021. The main type of the retracted papers was research article, and the main reason for retraction was academic misconduct. The retractions were mainly concentrated in several major publishers and periodicals in Europe and the United States. Most of the journals had low-impact factors.
Efficacy of radioactive 125I seed implantation in treating inoperable or refused operation head and neck cancers
Authors: Zhang Yuwei , Liang Yansong , Liu Zezhou , Zhang Hongtao , Gao Zhen , Wang Juan 
Published: April 2024

ABSTRACT

Purpose:
This study aims to observe the curative effect of radioactive 125I seed implantation in treating inoperable or refused operation head and neck cancer.

Methods:
Data from 132 patients with head and neck malignant tumors underwent computed tomography-guided radioactive 125I seed implantation from April 2004 to August 2020 were analyzed retrospectively. The Kaplan-Meier method was used to calculate the local control and survival rates. The logarithmic rank test and the Cox proportional risk model were used for univariate and multivariate analysis, respectively.

Results:
A total of 132 patients were enrolled. All tumors were confirmed to be malignant through pathological analysis. Herein, we revealed that the seeds were implanted at the primary tumor site (23 cases, representing 17.4%), recurrent (9 cases, representing 6.8%), or metastatic lymph nodes (100 cases, representing 75.8%). Three months after the operation, 96 patients were evaluated as effective, whereas 36 patients were considered ineffective. The median local control time was 16 months; the local rates at 6, 12, 18, and 24 months were observed to be 75%, 47%, 35%, and 22%, respectively. The study reports a median survival period (OS) of 15 months. Additionally, the survival rates at 6, 12, 18, and 24 months were 61%, 42%, 31%, and 27%, respectively. Regarding side effects, skin or mucosal toxicity occurred in 14 patients. Grade I skin toxicity occurred in seven cases (5.3%), grade IV skin toxicity in one case (0.8%), grade I mucosal ulcer in four cases (3.0%), and grade I dry mouth in four cases (3.0%). The multivariate analysis showed that short-term efficacy and tumor site were independent prognostic factors (P < 0.001, 0.006, respectively). Additionally, the multivariate analysis showed that the independent OS influencing factors included D90, the longest tumor diameter, and short-term efficacy (P = 0.017, 0.001, <0.001).

Conclusion:
Radioactive 125I seed implantation is a safe and effective salvage therapy for patients with inoperable or refused operation head and neck cancer.
Bipolar Cautery in Aneurysms: Effective but Underutilised Technique
Authors: Janu Vikas , Sharma Raghavendra Kumar , Agrawal Mohit , Jha Ashutosh , Ruparelia Jigish , Bhaskar Suryanarayanan , Jha Deepak Kumar 
Published: April 2024

ABSTRACT

Background:
Bipolar cautery for aneurysms is an effective technique, described in the literature about 50 years back by Yasargil, however, there is an inadequacy of articles highlighting the technique.

Materials and Methods:
Operative videos of aneurysm surgeries were analysed to select the videos/photographs which can help readers to understand the technical nuances of using bipolar cautery during aneurysm surgeries. Cautery was used after the completion of sharp dissection around the neck and demarcation of proximal and distal vessels in non-giant aneurysms. Cautery setting was kept around 10%–20% of the maximum. Blunt tip forceps were used with continuous irrigation. A shaft instead of the tip of the cautery was used.

Results:
Bipolar cautery resulted in the shrinkage of the wall of the aneurysm. It had a similar effect on the neck, fundus or transition zone between the neck and fundus. It helped in controlling the bleeding from the fundus even during intraoperative rupture of the aneurysms. Even the flimsy wall of the fundus shrunk, which prevented their rupture during dissection. It was very useful to make giant aneurysm fundus shrink to a smaller size providing space for dissection. The wide neck could be modified to a desirable shape for easier clip applications.

Conclusion:
Fear of intraoperative rupture by cautery appears misconceived. It causes shrinkage of the wall of the aneurysm, can stop bleeding from the fundus and can change the shape of the neck fundus, which helps clipping the aneurysms easily.
The effect of emotional freedom techniques (EFT) on anxiety and caregiver burden of family caregivers of patients with heart failure: A quasi-experimental study
Authors: Marzban Arash , Akbari Mohammad , Moradi Mohsen , Fanian Nasrin 
Published: April 2024

BACKGROUND:
Family members are at the forefront of providing care to patients with chronic illnesses, such as heart failure (HF). Since patient caregiving can affect the mental and physical health of family caregivers, the implementation and training of new psychological interventions by nurses are considered important and necessary for family caregivers. Therefore, the aim of this study was to evaluate the effect of emotional freedom techniques (EFTs) on anxiety and caregiver burden of family caregivers of patients with HF.

MATERIALS AND METHODS:
This study was a quasi-experimental study, in which 91 family caregivers participated. The family caregivers were assigned into two groups of intervention (n = 46) and control (n = 45). Data were collected using a demographic information form, Zung Self-Rating Anxiety Scale (SAS), and Caregiver Burden Inventory (CBI) developed by Novak and Guest. The intervention group underwent EFT training within six sessions, while the control group received no training. Descriptive statistics (mean, standard deviation, and absolute and relative frequency) and inferential statistical tests such as Chi-square, Fisher’s exact, and independent t-tests were run, and the data were analyzed by Statistical Package for the Social Sciences (SPSS) version 23 software.

RESULTS:
The findings showed that the intervention group had a significant improvement in reducing anxiety (P > 0.001). In addition, EFT significantly reduced caregiver burden among family caregivers of HF patients (P > 0.001).

CONCLUSION:
EFT could significantly reduce anxiety and caregiver burden in family caregivers of patients with HF in our study. Therefore, nurses working in clinical settings are recommended to learn and use EFT to reduce the anxiety and caregiver burden of patients’ family caregivers.
The effect of extra virgin olive oil (EVOO) on fat mass and fat-free mass for breastfeeding mothers (0-24 months) in Makassar City, Indonesia
Authors: Abidin Sri W. , Citrakesumasari Citrakesumasari , Bahar Burhanuddin , Jafar Nurhaedar , Hidayanti Healthy , Hadju Veni 
Published: April 2024

BACKGROUND:
Extra Virgin Olive Oil (EVOO) is a fat source classified as monounsaturated fatty acid. Previous studies have shown that 47.5% of breastfeeding mothers have less fat intake when compared to the Adequacy of Nutrition Rate (RDA). EVOO consumption can improve the composition of breast milk. However, no research has been found regarding the body composition of breastfeeding mothers after consuming EVOO. This study aims to determine the effect of EVOO on the body composition of breastfeeding mothers 0-24 months.

MATERIALS AND METHODS:
The study was conducted at the Sudiang Raya and Tamalanrea Health Centers in Makassar City with a randomized clinical trial design from January to February 2023. The sample was breastfeeding mothers 0-24 months divided into the intervention group (EVOO and Nutrition Education, n = 17) and the control (Nutrition Education, n = 17). Instruments with Bioelectrical Impedence Analysis tools. Data analysis using t-test.

RESULTS:
The sample is breastfeeding mothers aged between ≤19 and >35 years. The results of the analysis showed that the average pre-post test, % fat mass (FM) P = 0.426 and % fat free mass (FFM) P = 0.508 (P > 0.05), meant that there was no significant difference. Between the two groups there was no significant difference at the end of the study, %FM P = 0.469 and %FFM P = 0.529 (P > 0.05).

CONCLUSIONS:
In the intervention group that was given EVOO, it was possible to maintain%FM and%FFM in the normal percentage range, while in the control group, there was a decrease from the normal to less/low range.
Antimicrobial effect of indocyanine green-mediated photodynamic therapy in patients with periodontal disease: A systematic review
Authors: AlSarhan Mohammed A 
Published: April 2024

Abstract

Aim:
This systematic review assessed the antimicrobial effect of indocyanine green-mediated photodynamic therapy (ICG-PDT) in patients with periodontal disease.

Materials and Methods:
Four electronic databases that is, MEDLINE, MEDLINE-In-Process, EMBASE, and Cochrane Library were systematically searched from their inception until December 22, 2022. Randomized controlled trials (RCTs) reporting the antimicrobial effect of ICG-PDT in patients with periodontal disease and published in English were included. The Cochrane risk of bias tool was used to assess the quality of the included RCTs. Two independent reviewers performed all the steps involved in a systematic review (primary and secondary screening, data extraction, and quality assessment). As the data extracted was not suitable for meta-analysis, the evidence was synthesized qualitatively.

Results:
Overall, seven RCTs from seven publications were included. All included studies had PDT, laser, or photothermal with ICG as the test group while the control group included low-level laser therapy, root surface debridement, and scaling and root planning. The bacterial species assessed across the included studies included Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Tannerella forsythia, Fusobacterium nucleatum, and Treponema denticola. With subtle exceptions, ICG-PDT in combination with root surface debridement and scaling and root planning significantly reduced the growth of periodontal pathogens from baseline.

Conclusion:
Based on the evidence from the limited studies, ICG-PDT seems to exhibit potent antimicrobial activity against an array of periodontal pathogens in patients with periodontal disease.
Bibliometric analysis of scientific production on botulinum toxin and dentistry: Collaboration, impact, and trends
Authors: Portocarrero-Reyes Alfredo , Javier-Felipe Carlos , Espinoza-Carhuancho Fran , Mayta-Tovalino Frank 
Published: April 2024

Abstract

Aim:
To conduct a detailed examination of the scientific literature on the topic of botulinum toxin in relation to dentistry, using bibliometric analysis methods.

Materials and Methods:
This study employed a retrospective and descriptive design with a bibliometric approach. The research focused on the intersection of botulinum toxin and dentistry, analyzing articles published from 2018 to 2023. This search was conducted on September 21, 2023. These articles were then organized and analyzed through metadata analysis. The selection criteria were defined based on the PICO question. Inclusion criteria encompassed research articles related to botulinum toxin and dentistry, published between 2018 and 2023, available in Scopus, and containing the specified keywords. Exclusion criteria were set to omit review articles, editorials, letters to the editor, commentaries, articles not written in English, articles that had not undergone peer review, and those whose full text was not accessible. This approach allowed for an objective measurement of variables using SciVal from Scopus, ensuring the reliability and validity of the study findings. The progressive increase in scientific production on botulinum toxin and dentistry over the last five years was thus effectively captured and analyzed.

Results:
From 2018 to 2023, the scientific production on botulinum toxin and dentistry was higher in Q2 and Q1. 2019 was the only year where there were a higher number of publications in Q1, since in the other years the publications were mostly in Q2. The scientific journal with the highest average of publications on this topic was the British Journal of Oral and Maxillofacial Surgery. Most of the publications were from Peking University, China, and the Universidade de Sao Paulo. The most prolific author was Paulo César Rodrigues Conti, and the countries with the most publications on botulinum toxin and dentistry were the United States and Brazil.

Conclusions:
During the last five years, the scientific production on botulinum toxin and dentistry has progressively increased, with most of the publications being in the Q2 and Q1 quartiles. The United States was the country with the highest number of publications. The author, Paulo César Rodrigues Conti, was the researcher with the highest average manuscripts.