bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the heat recovery of the spray dryers by using the tube-finned heat exchanger with elliptical holes
Authors: Moghaddam Hossein Reza , Javaherdeh Kourosh 
Published: May 2024

Abstract

In this paper, the applicability of the heat exchangers for the heat recovery and energy saving purposes in spray dryers by utilizing Computational Fluid Dynamics (CFD) is investigated. For this purpose, two different tube-finned heat exchangers with the elliptical holes are added to the equipment. The first one gives the heat of the exhaust air and the second one translates the recovered heat from the exhaust air to the atomizing air. Initially, the effect of different parameters on the heat exchangers are studied. Then, numerically the effect of adding heat exchanger on the factory performance is evaluated. It is observed that by adding the mentioned heat exchangers, the energy consumption and energy price of the factory and the spray dryer decreases. Hence, the suggested equipment can be used for energy saving in the spray dryers.
Development of the Theory-Based Exercise Education and Prescription Smartphone Application for Sedentary Individuals: A Randomized Controlled Trial
Authors: GÜR Fatih , Ayan Vedat 
Published: May 2024

Abstract

Introduction: This study aims to develop and test a Cognitive-Behavioral Theory (CBT) based mobile application in accordance with the evidence-based physical activity recommendations in order to improve the health-related physical fitness parameters of university students with inadequate levels of physical activity.
Methods: Participants were selected from students at … University, who did not meet the lowest level of physical activity recommended by the World Health Organization and the American College of Sport Medicine for healthy adults for the past 6 months. Experimental research design with randomized control group was used in the study. Participants were randomly distributed into the experimental (n=63) and control groups (n=62). Participants in the experimental group performed an average of 40 minutes of aerobic, strength and flexibility exercises 4 days a week for 8 weeks, using the Exercise Education and Prescription (ERVE) mobile application, developed within the scope of the research. They also received CBT-based exercise education through the ERVE application. Participants were evaluated for health-related physical fitness parameters before and after the study.
Results: As a result of the 8-week application through ERVE, the maximum oxygen consumption, maximum push-ups, maximum sit-ups, hand grip strength and body flexion values of the participants in the experimental group was found to statistically significantly differ than that of the control group (p<0.05).
Conclusions: As a result, the ERVE mobile application can help university students with insufficient levels of physical activity increase their physical activity levels and improve some of the health-related physical fitness parameters.
Unraveling Proteomic Adaptations to Moderate Heat Stress in Arabidopsis thaliana: Insights for Developing Thermotolerant Crops
Authors: Fan Kai-Ting , Xu Yuan 
Published: May 2024

Abstract

The imminent danger of global warming jeopardizes plant survival, leading to negative consequences for growth and agricultural productivity. A thorough understanding of how plants respond to heat stress at the molecular level is essential for the development of thermotolerant crops. To delve into this intricate mechanism, we embarked on exploring proteome dynamics in Arabidopsis thaliana seedlings under moderate heat stress conditions (30°C), employing an innovative blend of 15N-stable isotope labeling and the ProteinTurnover algorithm. This method enabled a meticulous examination of proteomic alterations across various cellular fractions. Our investigation unearthed significant turnover rate changes in 571 proteins, with a median increase of 1.4-fold, reflecting accelerated protein dynamics during heat stress. Notably, root soluble proteins displayed subtler changes, hinting at tissue-specific adaptations. We also observed remarkable turnover variations in proteins associated with redox signaling, stress response, and metabolism, underscoring the intricate nature of the response network. Conversely, proteins involved in carbohydrate metabolism and mitochondrial ATP synthesis exhibited minimal turnover changes, indicating their stability. This comprehensive analysis provides insights into the proteomic adjustments of Arabidopsis seedlings to moderate heat stress, shedding light on the delicate balance between proteome stability and adaptability. These findings significantly contribute to our understanding of plant thermal resilience and offer valuable support for the development of crops endowed with enhanced thermotolerance.
Fusion of Multiple Self-Diagnostic Questionnaires into Optimal Diagnostic Cut-offs and Factor Analysis for Depression Characterization of the Korean University Student Group
Authors: Lee Soojin , Lee Sukhan , Lee Jungsun , Jo Youngtak , Park Eunil , Cha Junyeop 
Published: May 2024

Abstract

Background: The diagnostic cut-offs and factor analysis prepared for a general population by depression self-questionnaires are inadequate for a focused population with its cultural background. Therefore, we present a novel approach to optimizing diagnostic cut-offs and generalizing factor analysis for the Korean university student group in the fusion space of multiple self-questionnaires.
Methods: We collected the data from 30 randomly selected Korean university students, over 21 weeks, with the psychiatric evaluation as a reference, then established the optimal cut-off regions in the fused CESD−­PHQ9 score space based on the statistical correlation between CES−D and PHQ−9 and the reference diagnostics. We also re-extracted the factors in the fused CESD−PHQ9 space to expose the key factors that are behind the depression characteristics of the group.
Results: The proposed approach is population-specific cut-off regions, which can provide more reliable and trustworthy diagnoses. On the extended factor analysis, we identified the major factors of the depression characteristics of the group to be the “socio-psychological” and “interpersonal relationship” associated with academic studies and employment.
Limitations: Since there is a lack of evaluation of the accuracy of the proposed approach with the clinical diagnosis, whether it can effectively fulfill the role of intermediate diagnosis between patients and psychiatrists needs to be verified.
Conclusion: We identified optimal cut-off regions and generalized factor analysis in the fusion space. Finally, these can serve as a self-diagnostic tool for reliably identifying the depression characteristics of a focused population as well as effectively linking individuals and psychiatrists as an intermediary.
Sistem Check-In Di Lingkungan Sma Budya Wacana Dengan Memanfaatkan Qr Code Dan Geolokasi
Authors: Gozales Ferdinand , Maria Nila Anggia Rini  , Lukas Chrisantyo  
Published: May 2024

Technology began to develop rapidly at that time. Many tools have been invented to facilitate human work, one of which is the Quick Response Code. QR codes are two-dimensional matrix codes or barcodes created to allow scanners to respond quickly and receive data quickly. QR codes can be used to manage the attendance of students, teachers, and school staff. This study defines a QR code work system for student, teacher, and staff badges to manage student, teacher, and staff activity data and keep track of all students attending school. employee activities. This study uses the Waterfall System Development Life Cycle method. The key component of the system is a webcam scanner that reads QR codes filled with master keys for student, teacher, and staff data. Attendance plays an important role in all institutions. This can lead to errors on the part of the school or students. For example, inefficient use of paper, absenteeism, missing monthly reports, missing wastepaper, etc. In addition, handwritten attendance carries the risk of absenteeism due to corruption of attendance data, which can lead to carelessness by employees and students.

Intisari— Teknologi saat itu mulai berkembang pesat. Telah banyak ditemukan alat untuk mempermudah pekerjaan manusia, salah satunya adalah Quick Response Code. Kode QR adalah kode matriks atau barcode dua dimensi yang dibuat untuk memungkinkan pemindai merespons dengan cepat dan menerima data dengan cepat. Kode QR dapat digunakan untuk mengelola kehadiran siswa, guru, dan staf sekolah. Studi ini mendefinisikan sistem kerja kode QR untuk lencana siswa, guru, dan staf untuk mengelola data aktivitas siswa, guru, dan staf serta melacak semua siswa pergi ke sekolah. aktivitas karyawan. Penelitian ini menggunakan metode Waterfall System Development Life Cycle. Komponen kunci dari sistem ini adalah pemindai webcam yang membaca kode QR yang diisi dengan kunci utama untuk data siswa, guru, dan staf. Kehadiran memainkan peran penting di semua institusi. Hal ini dapat menimbulkan kesalahan dari pihak sekolah atau siswa. Misalnya, penggunaan kertas yang tidak efisien, ketidakhadiran, laporan bulanan yang hilang, dan kertas bekas yang hilang. Selain itu, presensi tulisan tangan memiliki risiko presensi karena rusaknya data presensi yang dapat menimbulkan
Penerapan Sistem Rekomendasi Registrasi Mata Kuliah Informatika UKDW
Authors: Kristian Hartono Renaldi , Mahastama Aditya Wikan , Lukito Yuan 
Published: May 2024

Setiap tahun ajaran baru dimulai, prodi Informatika UKDW akan menyediakan mata kuliah yang dapat dipilih mahasiswa saat melakukan registrasi. Mata kuliah yang disediakan ini pada dasarnya dibagi menjadi mata kuliah wajib dan mata kuliah pilihan. Berdasarkan 2 macam mata kuliah ini, bagi Mahasiswa Informatika terutama dalam memilih mata kuliah pilihan seringkali disesuaikan dengan bidang minat dari masing-masing mahasiswa. Bidang minat ini yang kemudian disesuaikan dengan mata kuliah yang ada pada saat registrasi, namun walaupun demikian bagi Mahasiswa Informatika sering mengalami kebingungan dalam memilih mata kuliah pada saat registrasi.

Oleh sebab itu penelitian ini akan merancang sebuah sistem rekomendasi mata kuliah yang digunakan untuk membantu merekomendasikan mata kuliah kepada Mahasiswa Informatika UKDW sebelum melakukan registrasi. Terdapat 2 mesin yang digunakan sistem dalam memproses rekomendasi yaitu Python dan Laravel. Proses rekomendasi yang dilakukan oleh Python akan menggunakan Item-Based Collaborative Filtering yang memiliki proses diantaranya mengumpulkan data berupa hasil rating mata kuliah, memproses similarity antar mata kuliah untuk tiap bidang minat, serta menghitung matriks evaluasi dengan menggunakan MAP. Kemudian hasil dari similarity yang paling tinggi akan digunakan sebagai kriteria untuk menampilkan rekomendasi menggunakan Laravel.

Sistem dilakukan uji coba dengan 10 testcase berupa skenario mahasiswa dari angkatan 2021, 2020 dan 2019. Hasil testcase menunjukkan mata kuliah yang seharusnya diambil mahasiswa, sedangkan evaluasi terkait dengan hasil mata kuliah yang direkomendasikan sistem. Hasil evaluasi testcase dinyatakan memiliki tingkat keberhasilan 80% berdasarkan 8 dari 10 testcase yang berhasil. Selanjutnya sistem memiliki tingkat keakuratan untuk mata kuliah bidang minat sebesar 46.36% yang dihitung menggunakan metode Mean Average Precision (MAP) dengan melakukan rata-rata berdasarkan presisi dari 10 testcase. Presisi dihitung dalam dengan cara membandingkan mata kuliah bidang minat yang telah direkomendasikan dengan mata kuliah bidang minat yang telah diambil pada tiap testcase.
The effectiveness of minimally invasive surgical techniques for treating patients with chronic venous insufficiency in the stage of trophic disorders: comparative study
Authors: Khitaryan A. G. , Veliev K. S. 
Published: May 2024

Introduction. Despite the active introduction of minimally invasive techniques into modern phlebology, the problem of surgical treatment of chronic venous insufficiency (CVI) in the stage of trophic disorders is still far from being finally resolved, especially problems of horizontal reflux. Aim. Тo comparatively evaluate the results of using various tactics of minimally invasive surgical treatment in patients with lower extremitiesʹs CVI in the stage of trophic disorders.Materials and methods. A study at 139 patients with CVI at the stage of trophic disorders was carried out. Group 1 (n = 79) included patients who underwent endovasal laser coagulation of the trunks of the great and small saphenous veins (GSV and SSV) with microfoam sclerotherapy of varicose perforating veins. In group 2 (n = 60) – method of intervention was determined by the diameter of Cockettʹs perforants.Results. Indicators of the early postoperative period in the study groups were comparable. After 2 months, no cases of relapse in the GSV and SSV were registered. Recurrence of horizontal reflux was observed only in 6 (7.6%) people in group 1. In long-term postoperative follow-up, decrease in the severity of the disease according to the VCSS scale was found in both groups (p < 0.001). The persistence of pathological reflux along was observed in 16 (22.5%) patients of group 1. Moreover, in 62.5% and 68.75% cases of relapses, the perforants had, respectively, a large diameter and high blood flowʹs speed.Discussion. In general, minimally invasive techniques used demonstrated comparable clinical results and high efficiency. At the same time, the importance of preoperative assessment and taking into account the properties of perforants has been proven.Conclusion. The claimed method should be considered as an effective and safety method of obliteration of incompetent perforating veins at severe forms of CVI.
Identification of relapse predictors of IgG<sub>4</sub>-related sclerosing cholangitis
Authors: Guseva A. K. , Okhlobystin A. V. 
Published: May 2024

Introduction. Relapses occur in 30–50% of patients IgG4-related sclerosing cholangitis. Relapses may act an independent risk factor for malignancy development and the need in maintenance therapy for relapse prevention is still uncertain. Thus, studying relapse predictors and developing reliable preventive approaches is an important area of research for this condition.Aim. To determine relapse predictors of IgG4-related sclerosing cholangitis.Materials and methods. A single- center dynamic bidirectional observational study was conducted in patients aged 18 years and older with verified IgG4-related sclerosing cholangitis (n = 32). We searched for possible factors influencing the relapse of IgG4- related sclerosing cholangitis. The development of a prognostic model for the relapse probability was carried out using logistic regression. ROC analysis was used to assess the diagnostic performance of quantitative variables in predicting of relapse.Results. The median follow-up period was 33 (16–60) months. The majority of patients with IgG4-related sclerosing cholan- gitis were male (71.9%), median age was 59 ± 13 years. In most patients, delayed diagnosis (median 10.5 [4.8; 22.5] months) was associated with overdiagnosis of primary sclerosing cholangitis (41.2%) or bile duct malignancy (43.8%). Surgical interventions were performed in 50% of patients. Median serum IgG4 level was 2.70 g/L [1.92; 6.48], and 21.9% of patients had normal serum IgG4 level. Disease relapse developed in 34.4% (n = 11) of patients. Serum IgG4 level before glucocorticosteroid therapy ≥ 2.24 g/L and a delay in diagnosis by ≥ 17 months were associated with the relapse (p = 0.040 and p = 0.049 respectively). Multi-organ involvement, and extrahepatic localization of biliary strictures in the patients with the history of surgical interventions increased the risk of relapse 85 (p = 0.001) and 12 (p = 0.047) fold, respectively. The presence of biliary strictures below the confluence reduced the risk of relapse 7.5 fold (p = 0.032).Conclusions. Possible predictors of IgG4-related sclerosing cholangitis relapse may include multi- organ involvement, intrahepatic and proximal extrahepatic strictures, prior surgical interventions in patients with extrahepatic strictures, high serum IgG4 level, and delayed diagnosis.
Dominant Circulating Cell-free Mycobacterial Proteins in In-use
Machining Fluid and their Antigenicity Potential
Authors: Chandra Harish , Ahlers Bethany , Lam Ying Wai , Yadav Jagjit S. 
Published: May 2024

Background:
Occupational exposure to industrial Metalworking Fluid (MWF) colonized
by Mycobacterium immunogenum (MI) has been associated with immune lung disease hypersensitivity
pneumonitis (HP) in machinists. This warrants regular fluid monitoring for early detection
of mycobacterial proteins, especially those with antigenic potential.

Objective:
To detect and identify dominant MI proteins and antigens directly from the field-drawn
in-use MWF using an integrated immunoproteomic and immunoinformatic approach.

Methods:
An MI-positive MWF selected by DNA-based screening of several field-drawn MWF
samples were cultured to isolate the colonizing strain and profiled for dominant circulating cell-
free (ccf) MI proteins, including antigens using an integrated immunoproteomic (1D- and 2Dgel
fractionation of seroreactivity proteins combined with shotgun proteomic analysis using LC-MS/
MS) and immunoinformatic strategy.

Results:
A new MI strain (MJY-27) was identified. The gel fractionated MI protein bands (1Dgel)
or spots (2D-gel) seroreactive with anti-MI sera probes (Rabbit and Patient sera) yielded 86
MI proteins, 29 of which showed peptide abundance. T-cell epitope analysis revealed high
(90-100%) binding frequency for HLA-I& II alleles for 13 of the 29 proteins. Their antigenicity
analysis revealed the presence of 6 to 37 antigenic determinants. Interestingly, one of the identified
candidates corresponded to an experimentally validated strong B- and T-cell antigen (AgD)
from our laboratory culture-based studies.

Conclusion:
This first report on dominant proteins, including putative antigens of M. immunogenum
prevalent in field in-use MWF, is a significant step towards the overall goal of developing
fluid monitoring for exposure and disease risk assessment for HP development in machining environments.

Conclusion::
This first report on dominant proteins, including putative antigens of M. immunogenum
prevalent in field in-use MWF, is a significant step towards the overall goal of developing
fluid monitoring for exposure and disease risk assessment for HP development in machining environments.
Influences of Ipomoea batatas Anti-Cancer Peptide on Tomato Defense
Genes
Authors: Lin Hsin-Hung , Lin Kuan-Hung , Tsai Yung-Lin , Chen Rong-Jane , Lin Yen-Chang , Chen Yu-Chi 
Published: May 2024

Aims:
This study investigates the impact of IbACP (Ipomoea batatas anti-cancer peptide)
on defense-related gene expression in tomato leaves, focusing on its role in plant defense
mechanisms.

Background:
IbACP was isolated from sweet potato leaves, and it was identified as a
peptide capable of inducing an alkalinization response in tomato suspension culture media. Additionally,
IbACP was found to regulate the proliferation of human pancreatic adenocarcinoma
cells.

Objective:
Elucidate IbACP's molecular influence on defense-related gene expression in tomato
leaves using next-generation sequencing analysis.

Methods:
To assess the impact of IbACP on defense-related gene expression, transcriptome data
were analyzed, encompassing various functional categories such as photosynthesis, metabolic processes,
and plant defense. Semi-quantitative reverse-transcription polymerase chain reaction analysis
was employed to verify transcription levels of defense-related genes in tomato leaves treated
with IbACP for durations ranging from 0 h (control) to 24 h.

Results:
IbACP induced jasmonic acid-related genes (LoxD and AOS) at 2 h, with a significant
up-regulation of salicylic acid-dependent gene NPR1 at 24 h. This suggested a temporal antagonistic
effect between jasmonic acid and salicylic acid during the early hours of IbACP treatment.
Downstream ethylene-responsive regulator genes (ACO1, ETR4, and ERF1) were consistently
down-regulated by IbACP at all times. Additionally, IbACP significantly up-regulated the gene expressions
of suberization-associated anionic peroxidases (TMP1 and TAP2) at all time points, indicating
enhanced suberization of the plant cell wall to prevent pathogen invasion.

Conclusion:
IbACP enhances the synthesis of defense hormones and up-regulates downstream defense
genes, improving the plant's resistance to biotic stresses.
Effect of Rotenone on the Neurodegeneration among Different Models
Authors: Subhan Iqra , Siddique Yasir Hasan 
Published: May 2024

:
Rotenone is a naturally occurring plant product used as an insecticide, pesticide and piscicide. It is lipophilic in nature and can cross the blood-brain barrier and induce the degeneration
of neurons. It inhibits the mitochondrial respiratory chain complex I and stops the transfer of electrons. It induces ROS generation, which impairs mitochondrial activity. Rotenone is a toxic agent
which causes the death of neurons. The present review describes the effect of rotenone on neurodegeneration with an emphasis on behavioral, pathological and neuropathological components carried out on various experimental models such as cell lines, Drosophila melanogaster, mice and
rats.
Phytochemicals: Promising Inhibitors of Human Rhinovirus Type 14 3C
Protease as a Strategy to Fight the Common Cold
Authors: Tsilimingkra Nefeli Theodora , Papaneophytou Christos 
Published: May 2024

Background::
Human rhinovirus 3C protease (HRV-3Cpro) plays a crucial role in viral
proliferation, establishing it as a prime target for antiviral therapy. However, research on identifying
HRV-3Cpro inhibitors is still limited.

Objective::
This study had two primary objectives: first, to validate the efficacy of an end-point colorimetric
assay, previously developed by our team, for identifying potential inhibitors of
HRV-3Cpro; and second, to discover phytochemicals in medicinal plants that inhibit the enzyme's
activity.

Methods::
Rupintrivir, a well-known inhibitor of HRV-3Cpro, was used to validate the colorimetric
assay. Following this, we conducted a two-step in silico screening of 2532 phytochemicals, which
led to the identification of eight active compounds: apigenin, carnosol, chlorogenic acid, kaempferol,
luteolin, quercetin, rosmarinic acid, and rutin. We subsequently evaluated these candidates in
vitro. To further investigate the inhibitory potential of the most promising candidates, namely,
carnosol and rosmarinic acid, molecular docking studies were performed to analyze their binding
interactions with HRV-3Cpro.

Results::
The colorimetric assay we previously developed is effective in identifying compounds
that selectively inhibit HRV-3Cpro. Carnosol and rosmarinic acid emerged as potent inhibitors, inhibiting
HRV-3Cpro activity in vitro by over 55%. Our analysis indicated that carnosol and rosmarinic
acid exert their inhibitory effects through a competitive mechanism. Molecular docking
confirmed their competitive binding to the enzyme's active site.

Conclusion::
Carnosol and rosmarinic acid warrant additional investigation for their potential in
the development of common cold treatment. By highlighting these compounds as effective
HRV-3Cpro inhibitors, our study presents a promising approach for discovering phytochemical inhibitors
against proteases from similar pathogens.