bluuebunny/crossref_metadata_2025_split huggingface dataset:
Die Beeinflussung der enzymaktivitätshemmenden Wirkung von Imidazol‐Aiitimyzetika durch Glukokortikoide
Authors: Raab W. , Högl F. 
Published: January 2012

Zusammenfassung: Als weiterer Beitrag zur Frage nach Interaktionen zwischen Imidazol‐Derivaten und Glucocorticoiden wurde die Wirkung von Prednisolon‐21‐hemisuccinat‐Natrium, bzw. Triamcinolonacetonid auf die enzymhemmende Aktivität von Econazolnitrat untersucht. Interaktionen konnten nicht festgestellt werden: In niedrigen Konzentrationen lassen die Glucocortidcoide die durch Econazolnitrat venusachte Enzymhemmung unbeeinflußt. In höheren Konzenhtionen läßt sich ein additiver Effekt der beiden Wirkstoffgruppen nachweisen. Hierbei ist zu berücksichtigen, daß auch die untersuchten Glucocorticoide für sich allein eine Hemmwirkung der beiden Testenzyme G‐6‐PDH (Glucose‐6‐Phosphat‐Dehydrogenase) und SP („Saure” Phosphatase) venusachen.Für den Kliniker bedeuten diese Ergebnisse, daß auch in biochemischen Modellen ein Antagonismus zwischen Glucocorticoiden und Imidazol‐Derivaten nicht eintritt und somit dem the‐rapeutischen Einsatz der Kombination nicht entgegensteht.Summary: As a further contribution to the problem of interactions between imidazole derivatives and glucocorticoids, the influence of prednisolone‐21‐hemisuccinate‐sodium and triamcinolone actonide on the enzyme‐inhibitory activitiy of econazole nitrate was investigated. Interactions which might be indicative for some counteraction were absent: in low concentrations, glucocorticoids failed to exert any changes in the enzyme inhibition provoked by the imidazole antifungal; in higher concentrations, an additive effect was seen between the enzyme inhibition exerted by glucocorticoids and the enzyme inhibition exerted by econazole nitrate. The enzymes under investigation were giucose‐6‐phosphate dehydrogenase and “acid” phosphatase.For the clinicians, these results confirm the lack of biochemical interactions between glucocorticoids and imidazole derivatives, as they were combined for topical antifungal therapy.
Die Beeinflussung der membranschädigenden Wirkung von antimyzetisch wirksamen Imidazolderivaten durch Glucocorticoide
Authors: Högl F. , Raab W. 
Published: January 2012

Zusammenfassung: Als weiterer Beitrag zur Frage nach Interaktionen zwischen Imidazol‐Derivaten und Glucocorticoiden wurde die Wirkung von Prednisolon‐21‐hemisuccinat‐Natrium auf die membranschädigende Wirkung von Econazolnitrat auf Mitochondrien der Rattenleber untersucht.Die Einwirkung von Econazolnitrat auf die Aktivität der „Sauren” Phosphatase wurde durch die Anwesenheit des Glucocorticoids gehemmt, jedoch trat dieser „Schutzeffekt” erst dann ein, wenn die Konzentration des Glucocorticoids das Zehnfache der Konzentration von Econazolnitrat betrug.An Hand der vorliegenden Ergebnisse wird das zur Frage nach Interaktionen zwischen Imidazol‐Derivaten und Glucocorticoiden vorliegende Schrifttum diskutiert.Summary: As a further contribution to the problem of interactions between glucocorticoids and antifungal imidazole derivatives, the influence of prednisolone‐21‐hemisuccinate sodium on the membrane disrupting activity of econazole nitrate was investigated. If the concentration of the glucocorticoid was more than ten times higher than the concentration of the imidazole derivative, the membranes were protected: less acid phosphatases were liberated from the rat liver mitochondria. On the other hand, however, in the relative concentrations as the two types of compounds were used clinically, no antagonistic effect could be demonstrated. This result confirms the lack of interactions between glucocorticoids and antifungal imidazole derivatives as they were combined in topical antimicrobial/antiinflammatory preparations.
Mycetoma of the Hand Caused by Phialophora Jeanselmei
Authors: Pupaibul K. , Sindhuphak W. , Chindamporn A. 
Published: January 2012

Summary: A case of mycetoma of the hand caused by Phialophora jeanselmei is described. The causative agent was identified by histological structure of the grains and by cultural and physiological characteristics of the fungus. The case presented in this report appears to be the second case of mycetoma of the hand caused by this pathogen in Thailand.Zusammenfassung: Bericht über einen Fall eines Mgzetoms der Hand, hervorgerufen durch Phialophora jeanselmei. Der Erreger wurde durch die histologische Struktur der Granula sowie durch die mgkologische Kultur und durch Prüfung seiner physiologischen Eigenschaften identifiziert. Es handelt sich bei diesem Fall um den zweiten Bericht aus Thailand über ein Myzetom der Hand durch Ph. jeanselmei.
Dermatophytosis due to Microsporum gypseum in a Pet Rabbit‐A Case Report
Authors: Sinha B. K. , Prasad C. B. , Sinha M. N. , Prasad L. N. 
Published: January 2012

Summary: A case of dermatophytosis in a two months old pet rabbit due to Microsporum gypseum has been reported. This is the first report from Bihar and the second from India.Zusammenfassung: Bericht über eine Microsponun gypseum‐Infektion bei einem zwei Monate alten Kaninchen. Es handelt sich um den ersten derartigen Bericht aus Bihar und um die zweite Mitteilung aus Indien.
Awake GlideScope intubation in a critically ill pediatric patient
Authors: Fraser‐Harris Eva , Patel Yash 
Published: January 2012

SummaryWe report a challenging case of a 10‐year‐old boy with history of biventricular heart failure, pulmonary hypertension, severe asthma, and obesity with a BMI of 37. He presented to our hospital in acute decompensated heart failure. Our anesthesia team was consulted by the pediatric intensivist for urgent airway management in this rapidly deteriorating, premorbid patient. We describe here the use of the GlideScope® in an awake pediatric patient of ASA 4E status with a potentially difficult airway who required to remain in the seated position and thus necessitating a face‐to‐face approach.
Correction of distal limb prolapse of a diverting colostomy by stapling under sedation
Authors: Arenal J. J. , Tinoco C. , Benito C. , Citores M. A. , Visa J. 
Published: January 2012

AbstractAim  To describe a surgical technique to treat colostomy prolapse as a day case procedure with the patient under sedation and analgesia.Method  A 60‐mm GIA Universal Stapler is inserted into the lumen of the prolapsed colon at right angles to the contour of the abdominal wall. Several firings are then made to completely divide the prolapsed colon. The instrument is then placed parallel to the skin to remove the prolapsed portion leaving 1–2 cm of bowel above the level of the skin.Results  Two patients underwent the procedure. The operation times were 30 and 13 min. Both took oral liquids 2 h after surgery and solids 2 h later. They were discharged at 24 and 4 h after surgery, respectively. No postoperative pain was reported in either case. At 14 and 6 months of follow‐up there has been no recurrence.Conclusion  Stapling treatment of prolapsed colostomies has the advantage of being an extra‐abdominal procedure. It is performed under sedation and analgesia, the operation time is very short, recovery to normal life is rapid and there is less likelihood of complications by avoiding a laparotomy.
Exenatide and sitagliptin are not associated with increased risk of acute renal failure: a retrospective claims analysis
Authors: Pendergrass M. , Fenton C. , Haffner S. M. , Chen W. 
Published: January 2012

Aim: This study evaluated whether the risk of acute renal failure (ARF) increases with exenatide and sitagliptin use.Methods: A retrospective cohort study of a large medical and pharmacy claims database was performed. Data for 4 91 539 patients were analysed. Cox proportional hazard models were used to compare the risk of ARF between diabetic and non‐diabetic subjects and between diabetic patients treated with exenatide, sitagliptin and control medications.Results: Adjusted Cox analyses showed diabetic subjects had a higher risk of ARF [HR 1.51, confidence interval (CI) 1.26–1.81, p < 0.001] than non‐diabetic controls. Compared with diabetic controls, neither exenatide (HR 0.77, CI 0.42–1.41, p = 0.40) nor sitagliptin (HR 1.17, CI 0.82–1.65, p = 0.39) increased the risk of ARF.Conclusion: Our study revealed an increased incidence of ARF in diabetic versus non‐diabetic patients but no association between use of exenatide or sitagliptin and ARF. Because of the limitations of this observational analysis, we cannot exclude the possibility of a very small increased risk.
Efficient Image‐Based Proximity Queries with Object‐Space Precision
Authors: Morvan T. , Reimers M. , Samset E. 
Published: January 2012

AbstractWe present an efficient algorithm for object‐space proximity queries between multiple deformable triangular meshes. Our approach uses the rasterization capabilities of the GPU to produce an image‐space representation of the vertices. Using this image‐space representation, inter‐object vertex‐triangle distances and closest points lying under a user‐defined threshold are computed in parallel by conservative rasterization of bounding primitives and sorted using atomic operations. We additionally introduce a similar technique to detect penetrating vertices. We show how mechanisms of modern GPUs such as mipmapping, Early‐Z and Early‐Stencil culling can optimize the performance of our method. Our algorithm is able to compute dense proximity information for complex scenes made of more than a hundred thousand triangles in real time, outperforming a CPU implementation based on bounding volume hierarchies by more than an order of magnitude.
Inadequate Bivariate Measures of Health Inequality: The Impact of Income Distribution*
Authors: Brekke Kjell Arne , Kverndokk Snorre 
Published: January 2012

AbstractBivariate measures of health inequality are influenced by changes in two variables: health and a socioeconomic variable, such as income. For these measures, what is reported as an increase in health inequality might just as well be a reduction in income inequality. In particular, several papers have found that socioeconomic health inequalities in Nordic countries are no less than in other European countries. The correct interpretation could just be that income inequality is no higher in Nordic countries than in the rest of Europe. The problem is especially profound when the causality is running from health to income.
The location of the thioglycolic acid molecules in intrafibrillar unordered areas of the human hair keratin structure
Authors: Zabashta Y. F. , Kasprova A. V. , Senchurov S. P. , Grabovskii Y. E. 
Published: January 2012

SynopsisIt has been established after conducting an X‐ray diffraction study of the structure of hair treated with the thioglycolic acid solution that the preferable location of thioglycolic acid molecules should be the intrafibrillar unordered areas. Based on this fact it has been concluded that the redistribution of disulphide bonds of hair occurs mainly in the mentioned above areas when treated with thioglycolic acid solution.
Safety and efficacy of flunarizine in childhood migraine: 11 years’ experience, with emphasis on its effect in hemiplegic migraine
Authors: PEER MOHAMED BASHEER , GOADSBY PETER J , PRABHAKAR PRAB 
Published: January 2012

Aim  The aim of this study was to report a single‐centre experience of flunarizine in childhood migraine with focus on safety and efficacy.Method  We conducted a retrospective observational audit of 72 individuals (40 male, 32 female; mean age 13y; age range 1y 6mo–17y) at a tertiary paediatric neurology unit between 1998 and 2009. Children were included if they had a diagnosis of migraine and at least one follow‐up assessment and a minimum of 3 months’ treatment with flunarizine.Results  Of 102 individuals identified, 30 were excluded for the following reasons: no outcome data (n=13), non‐migraineurs (n=9), missing records (n=4), or inadequate treatment duration (n=4). Of the final cohort (72 individuals), 44 had migraine without aura, 15 had migraine with aura or childhood migraine equivalents, eight had sporadic hemiplegic migraine, and five had familial hemiplegic migraine. The median age was 13 years (1y 6mo–17y) and median duration of migraine was 48 months. Starting dose was 5mg. Other doses used were 2.5mg (three individuals), 7.5mg (one individual), and 10mg (six individuals). Treatment duration was 12 months. Successful prophylaxis, defined as at least a 50% reduction in attack frequency, was observed in 57% (41/72). Response rate was higher among those with hemiplegic migraines (85%) than in those who did not have hemiplegic migraines (51%). Side effects were noted in 15 (21%) individuals (depression, n=6; weight gain/increased appetite, n=5; tiredness/sedation, n=2; and worsening headache, n=2), and led to discontinuation of treatment in 13.Interpretation  In our cohort of children with migraine, flunarizine appears to be more effective in the hemiplegic migraine group. Adverse effects were seen in one‐fifth of the individuals, leading to discontinuation in 18%.
Heavy maternal alcohol consumption and cerebral palsy in the offspring
Authors: O’LEARY COLLEEN M , WATSON LINDA , D’ANTOINE HEATHER , STANLEY FIONA , BOWER CAROL 
Published: January 2012

Aim  The aim of this study was to investigate the association between heavy maternal alcohol consumption and pre‐ peri‐ and postneonatally acquired cerebral palsy (CP).Method  The records of all mothers with an International Classification of Diseases, revision 9 or 10 (ICD‐9/‐10) alcohol‐related diagnostic code, indicating heavy alcohol consumption, recorded on population‐based health, mental health, and drug and alcohol data sets from 1983 to 2007, and their children were identified through the Western Australian Data‐linkage System. This ‘exposed’ cohort was frequency matched with mothers without an alcohol‐related diagnosis and their offspring (comparison group). Cases of CP were identified through linkage with the Western Australia CP Register. Analyses were undertaken using multivariate logistic regression.Results  There were 23 573 live births in the exposed group (58.6% non‐Aboriginal; 41.4% Aboriginal) and 292 cases of CP. The odds of pre/perinatally acquired CP were elevated for children of non‐Aboriginal mothers with an alcohol‐related diagnosis recorded during pregnancy (adjusted odds ratio 3.32; 95% confidence interval [CI] 1.30–8.48) and for Aboriginal children when an alcohol‐related diagnosis was recorded up to 12 months before the mother’s pregnancy (adjusted odds ratio 2.49; 95% CI 0.99–6.25). Increased odds of postneonatally acquired CP following any alcohol‐related diagnosis were found for non‐Aboriginal children (adjusted odds ratio 7.92; 95% CI 2.23–28.14).Interpretation  These results suggest that heavy maternal alcohol consumption is a direct cause of pre/perinatally acquired CP, and an indirect cause of postneonatally acquired CP, in non‐Aboriginal children. The lack of an association for Aboriginal children requires further investigation but may be due to under ascertainment of alcohol use disorders during pregnancy and other aetiological pathways.
Selection and preparation of hand and foot movements: Cz activity as a marker of limb system preparation
Authors: Miller Jeff 
Published: January 2012

AbstractEvent‐related potentials were used to examine the preparation of hand and foot responses in tasks using both limb systems. As in tasks using only one system, opposite lateralized readiness potentials were observed for hand and foot responses (Experiment 1). Furthermore, movement‐related activity at Cz was more positive prior to hand than foot responses, revealing that Cz activity can be used to index selective movement preparation by one limb system. In Experiment 2, two responses were cued prior to stimulus onset. Cue‐related activity at Cz was more positive with hand than foot cuing, reinforcing the conclusion that Cz activity is sensitive to selective preparation for one of these limb systems. Overall, the results show that it is possible to carry out motor preparation of two responses within the same limb system and that differential Cz activity is a useful index of this preparation in tasks with hand versus foot movements.
Effects of diet on synaptic vesicle release in dynactin complex mutants: a mechanism for improved vitality during motor disease
Authors: Rawson Joel M. , Kreko Tabita , Davison Holly , Mahoney Rebekah , Bokov Alex , Chang Leo , Gelfond Jon , Macleod Greg T. , Eaton Benjamin A. 
Published: January 2012

SummarySynaptic dysfunction is considered the primary substrate for the functional declines observed within the nervous system during age‐related neurodegenerative disease. Dietary restriction (DR), which extends lifespan in numerous species, has been shown to have beneficial effects on many neurodegenerative disease models. Existing data sets suggest that the effects of DR during disease include the amelioration of synaptic dysfunction but evidence of the beneficial effects of diet on the synapse is lacking. Dynactin mutant flies have significant increases in mortality rates and exhibit progressive loss of motor function. Using a novel fly motor disease model, we demonstrate that mutant flies raised on a low calorie diet have enhanced motor function and improved survival compared to flies on a high calorie diet. Neurodegeneration in this model is characterized by an early impairment of neurotransmission that precedes the deterioration of neuromuscular junction (NMJ) morphology. In mutant flies, low calorie diet increases neurotransmission, but has little effect on morphology, supporting the hypothesis that enhanced neurotransmission contributes to the effects of diet on motor function. Importantly, the effects of diet on the synapse are not because of the reduction of mutant pathologies, but by the increased release of synaptic vesicles during activity. The generality of this effect is demonstrated by the observation that diet can also increase synaptic vesicle release at wild‐type NMJs. These studies reveal a novel presynaptic mechanism of diet that may contribute to the improved vigor observed in mutant flies raised on low calorie diet.
Condom Use Trajectories in Adolescence and the Transition to Adulthood: The Role of Mother and Father Support
Authors: Pingel Emily S. , Bauermeister José A. , Elkington Katherine S. , Fergus Stevenson , Caldwell Cleopatra H. , Zimmerman Marc A. 
Published: January 2012

Few studies have investigated how mother and father support differ on predicting youths’ sexual risk behavior. We therefore examined the influence of parental support on condom use trajectories and its correlates in a predominantly African‐American sample (N = 627; 53% female participants; M = 14.86 years [SD = 0.64]) from adolescence to young adulthood. We used hierarchical growth curve modeling to examine the relationship between condom use, substance use, psychological distress, and parental support prospectively. We found that consistent condom use decreased over time and was associated negatively with psychological distress and substance use. Furthermore, both maternal and paternal support were associated with more condom use over time. We discuss the implications of our findings for HIV prevention programs.
Effect of Cardiac Resynchronization Therapy on Endothelium‐Dependent Vasodilatation in the Cutaneous Microvasculature
Authors: TESSELAAR ERIK , SCHIFFER ANGÉLIQUE , WIDDERSHOVEN JOS , BROERS HERMAN , HENDRIKS ERIC , LUIJTEN KEES , CREUSEN JOHN 
Published: January 2012

Aims:
Cardiac resynchronization therapy (CRT) improves hemodynamic parameters, exercise capacity, symptoms, functional status, and prognosis among patients with chronic heart failure (CHF). The role of the vascular endothelium in these improvements is largely unknown. In this study, we aimed to investigate whether the endothelium‐dependent reactivity of the peripheral microcirculation improves in CHF patients during the first 2 months of CRT.
Methods:
We used local heating and iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP) to measure endothelial function and smooth muscle function in the cutaneous microvasculature of 11 CHF patients before and 2 months after CRT.
Results:
We found that the perfusion response in the skin to local heating was increased 2 months post‐CRT compared with baseline, both in terms of maximum perfusion (baseline: 113 [90–137] vs 2‐months post‐CRT: 137 [98–175], P = 0.037) and area under curve (baseline: 1,601 [935–2,268] vs 2‐months CRT: 2,205 [1,654–2,757], P = 0.047). Also, the perfusion response to iontophoresis of ACh was improved (Emax: 23.9 [20.6–26.2]vs at 2‐months CRT: 31.2 [29.3–33.4], P = 0.005). No difference was found between the responses to SNP before and after CRT.
Conclusion:
These results show that CRT improves endothelium‐dependent vasodilatory capacity in the peripheral microcirculation within 2 months of therapy. The improvement in functional capacity that is seen in patients treated with CRT may, therefore, be in part mediated by an improvement of endothelium‐dependent vasodilatory capacity. PACE 2012; 35:377–384)
Neurovascular Proximity in the Diaphragm Muscle of Adult Mice
Authors: CORREA DIEGO , SEGAL STEVEN S. 
Published: January 2012

Please cite this paper as: Correa D, Segal SS(2012). Neurovascular proximity in the diaphragm muscle of adult mice. Microcirculation 19: 306–315, 2012.AbstractObjective:  Regional blood flow to the diaphragm muscle varies with the workload of inspiration. To provide anatomical insight into coupling between muscle fiber recruitment and oxygen supply, we tested whether arterioles are physically associated with motor nerve branches of the diaphragm.Methods:  Following vascular casting, intact diaphragm muscles of C57BL/6 and CD‐1 mice were stained for motor innervation. Arteriolar networks and nerve networks were mapped (∼2 μm resolution) to evaluate their physical proximity.Results:  Neurovascular proximity was similar between muscle regions and mouse strains. Of total mapped nerve lengths (C57BL/6, 70 ± 15 mm; CD‐1, 87 ± 13 mm), 80 ± 14% and 67 ± 10% were ≤250 μm from the nearest arteriole and associated predominantly with arterioles ≤45 μm in diameter. Distances to the nearest arteriole encompassing 50% of total nerve length (D50) were consistently within 200 μm. With nerve networks repositioned randomly within muscle borders, D50 values nearly doubled (p < 0.05). Reference lines within anatomical boundaries reduced proximity to arterioles (p < 0.05) as they deviated from the original location of motor nerves.Conclusion:  Across two strains of mice, motor nerves and arterioles of the diaphragm muscle are more closely associated than can be explained by chance. We hypothesize that neurovascular proximity facilitates local perfusion upon muscle fiber recruitment.
Effect of Dysprosia Additive on the Consolidation of CeO2 by Spark Plasma Sintering
Authors: Choi Kwanghoon , Reavis Richard E. , Osterberg Daniel D. , Jaques Brian J. , Butt Darryl P. , Mariani Robert D. , Burkes Douglas E. , Munir Zuhair A. 
Published: January 2012

The influence of dysprosia addition on the sintering and resulting microstructure of nano‐grained CeO2 ceramics was investigated as functions of the spark plasma sintering parameters. The addition of Dy2O3 (forming a solid solution) resulted in an increase in relative density and a decrease in grain size in sintered samples. The relative density of samples with Dy2O3 content of 6 and 10 mol% was over 95% when sintered at 1050°C under 500 MPa for holding times as short as 5 min. The application of high pressure facilitated the consolidation to relatively high densities with minimal grain growth. Heating rate and holding time, however, had insignificant effect on density but a measurable effect on grain size.