bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the Logic of Archaeological Inference: Early Formative Pottery and the Evolution of Mesoamerican Societies
Authors: Sharer Robert J. , Balkansky Andrew K. , Burton James H. , Feinman Gary M. , Flannery Kent V. , Grove David C. , Marcus Joyce , Moyle Robert G. , Price T. Douglas , Redmond Elsa M. , Reynolds Robert G. , Rice Prudence M. , Spencer Charles S. , Stoltman James B. , Yaeger Jason 
Published: May 2010

AbstractThe 2005 articles by Stoltman et al. and Flannery et al. to which Neff et al. (this issue) have responded are not an indictment of instrumental neutron activation analysis (INAA) but, rather, of the way Blomster et al. (2005) misuse it and of the hyperbolic culture-historical claims they have made from their INAA results. It has long been acknowledged that INAA leads not to sources but to chemical composition groups. Based on composition groups derived from an extremely unsystematic collection of sherds from only seven localities, Blomster et al. claim that the Olmec received no carved gray or kaolin white pottery from other regions; they also claim that neighboring valleys in the Mexican highlands did not exchange such pottery with each other. Not only can one not leap directly from the elements in potsherds to such sweeping culture-historical conclusions, it is also the case that other lines of evidence (including petrographic analysis) have for 40+ years produced empirical evidence to the contrary. In the end, it was their commitment to an unfalsifiable model of Olmec superiority that led Blomster et al. to bypass the logic of archaeological inference.
Preceramic Occupations in Belize: Updating the Paleoindian and Archaic Record
Authors: Lohse Jon C. , Awe Jaime , Griffith Cameron , Rosenswig Robert M. , Valdez Fred 
Published: May 2010

AbstractEvidence from preceramic Paleoindian and Archaic time periods in Belize has been recorded over the past quarter of a century by a number of projects. This paper summarizes previously published information and presents new archaeological data in bringing the hunting-and-gathering and itinerant horticultural millennia of this region into a more accurate and comprehensive perspective than has been presented to date. The Paleoindian period includes influences from North as well as South America, with settlement preferences shown for river valleys and near-coastal margins. Cave sites hold particular promise for yielding new and well-preserved remains from this early period. The Archaic, beginning as early as 8000 B.C., is poorly dated until 3400 B.C. and was probably characterized by mobile hunter-foragers. The Late Archaic includes two facets, the Early (3400–1900 B.C.) and the Late (1500–900 B.C.) Preceramic, and represents the first appearance and gradual spread of cultivation together with habitat modification. The period beginning around 1500 B.C. shows intensifying maize cultivation, apparently mobile populations, and also the emergence of well-defined stone tool traditions that trend into the early Middle Preclassic. Ceramics seem to appear unevenly from ca. 1200 to 900 B.C., when the Cunil and Kanocha complexes in western Belize and Swasey sphere in northern Belize are reported.
Long-Term Trends in Prehistoric Fishing and Hunting on Tobago, West Indies
Authors: Steadman David W. , Jones Sharyn 
Published: May 2010

AbstractWe compare the bone assemblages of Milford 1 (TOB-3) and Golden Grove (TOB-13) in Tobago, West Indies. Milford 1 is a small preceramic occupation (ca. 3000-2800 cal B.P.), whereas Golden Grove is a large ceramic-period village (ca. 1700-900 cal B.P.). Species richness at TOB-13 is greater than at TOB-3, both in marine (67 vs. 39 fishes) and terrestrial (32 vs. 9) taxa. Major shifts in marine exploitation from the preceramic to ceramic periods can be seen in relative abundance of tuna, toadfishes, and in fishes inhabiting mangrove and brackish water environments, and decreases in relative abundance of parrotfish, carnivorous reef fishes, and sea turtles. The abundance of tuna bones at TOB-13 is uniquely high among West Indian archaeological sites. For terrestrial taxa, the difference in species richness exceeds the expected, including decreased specialization on big game (peccaries) at TOB-13, with a greater tendency to hunt reptiles, birds, and mammals of all sizes at TOB-3. Factors underlying the shifts in fishing and hunting may include different collection methods and food preferences of non-Arawakan (preceramic) vs. Arawakan (ceramic) peoples, as well as human-induced declines in populations of peccaries, sea turtles, and selected fish species. Another possible factor is site setting, with the inhabitants of TOB-13 having enhanced access to mangrove habitats.
Wood of the Gods: The Ritual Use of Pine (Pinusspp.) by the Ancient Lowland Maya
Authors: Morehart Christopher T. , Lentz David L. , Prufer Keith M. 
Published: May 2010

AbstractThe recovery of pine (Pinus spp.) charcoal remains from ceremonial contexts at sites in the Maya Lowlands suggests that pine had a significant role in ancient Maya ritual activities. Data collected by the authors reveal that pine remains are a regular component of archaeobotanical assemblages from caves, sites that were used almost exclusively for ritual purposes, and that pine is often the dominant taxon of wood charcoal recovered. Comparisons with archaeobotanical data from surface sites likewise reveals that pine is common in ceremonial deposits. The authors propose that the appearance of pine remains in ceremonial contexts indicates pine was a valued element of Maya ritual paraphernalia. By basing interpretations with analogous information from ethnography, ethnohistory, iconography, and epigraphy, the use of pine during rituals is argued to be have been linked with a symbolic complex of ritual burning and offering “food” sacrifices to deities. The possibility is raised that burning pine, perhaps as torches, during some ancient rituals was similar to the modern use of candles. The diversity of ceremonial contexts yielding pine suggests that burning pine may have been a basic element of ritual activities that was essential to establish the legitimacy of ritual performances.
The Viejo Period of Chihuahua Culture in Northwestern Mexico
Authors: Stewart Joe D. , Kelley Jane H. , MacWilliams A. C. , Reimer Paula J. 
Published: May 2010

Abstract“Chihuahua culture” refers to two prehistoric periods of ceramic agricultural occupation in northwestern Mexico. It has long been known that the Medio period (ca. A.D. 1200–1450), with substantial adobe pueblo villages and towns, and ceramics that included elaborate polychrome wares, occurred over a vast region in western and northern Chihuahua and northeastern Sonora. It was also recognized that the preceding Viejo period, with pithouse and wattle-and-daub surface architecture, and less elaborate ceramics, was ancestral, at least in part. However, the geographical extent, dating, and nature of the Viejo-Medio transition were unclear. Recent research by several field projects has demonstrated that Viejo and Medio period occupations were geographically coextensive, as was the transition. A foundation for Viejo period chronometric dating (ca. A.D. 700–1200) is now established by 30 radiocarbon determinations from excavations in west central Chihuahua and one from northeastern Sonora. We discuss the dimensions of the Viejo period in west central Chihuahua with data from 1998–2000 excavations by the PAC (Proyecto Arqueológico Chihuahua). It provides an example of a broad-based transition from a relatively simple to a relatively complex pattern, and new perspectives on the interpretation of radiocarbon dating.”
More on Mesoamerican Cosmology and City Plans
Authors: Šprajc Ivan 
Published: May 2010

AbstractIn a recent comment Michael Smith argues that the cosmological interpretations of Maya urban layouts proposed in an article by Ashmore and Sabloff are vague and unconvincing. He also summarizes some other comparable studies in order to show that arguments for the cosmological significance of archaeologically recovered urban patterns are, in general, subjective and lack methodological rigor. I argue that his view is an unwarranted generalization and that his references to some archaeoastronomical interpretations do not adequately reflect the advances in this field of research and its relevance for the understanding of ancient city plans. I summarize the results of several studies in Mesoamerica, focusing on Teotihuacan and the Templo Mayor of Tenochtitlan discussed by Smith, to show that rigorous methods not only have been applied in archaeoastronomical research but also have resulted in explicit conclusions about specific aspects of worldview and political ideology underlying Mesoamerican architecture and urbanism.
Immune Complex-Mediated Enhancement of Secondary Antibody Responses
Authors: Goins Chelsey L. , Chappell Craig P. , Shashidharamurthy Rangaiah , Selvaraj Periasamy , Jacob Joshy 
Published: May 2010

Abstract
Immunologic memory is a hallmark of the vertebrate immune system. The first antigenic exposure leads to a slow and modest immune response, whereas repeated exposure, even many years later, leads to a rapid and exaggerated response that is two to three orders of magnitude greater than the primary. In the case of humoral immunity, the increased efficacy of recall responses is due to the production of amplified levels of Ag-specific Ab, as well as the accelerated kinetics of their production. Current thinking suggests that this is due to selective activation of long-lived, Ag-specific memory B cells. A downside of restricting secondary responses solely to memory cells is that the repertoire of the memory B cell pool remains static while pathogens continue to evolve. In this study, we propose that during secondary responses, naive Ag-specific B cells participate alongside memory cells. We show that immune complexes formed in vivo between the Ag and pre-existing Abs from the primary response activate these naive B cells, inducing them to respond with accelerated kinetics and increased magnitude. Thus, the continued recruitment of new B cell clones after each antigenic exposure enables the immune system to stay abreast of rapidly changing pathogens.
A Role for IL-1 Receptor-Associated Kinase-M in Prostaglandin E2-Induced Immunosuppression Post-Bone Marrow Transplantation
Authors: Hubbard Leah L. N. , Ballinger Megan N. , Thomas Peedikayil E. , Wilke Carol A. , Standiford Theodore J. , Kobayashi Koichi S. , Flavell Richard A. , Moore Bethany B. 
Published: May 2010

Abstract
Following immune reconstitution, hematopoietic stem cell transplant patients often display reduced immune function and are especially susceptible to lung infections. In a mouse model of syngeneic bone marrow transplantation (BMT), we previously reported that PGE2 is overproduced in lungs of BMT mice, significantly impairing host defense against Pseudomonas aeruginosa. This impairment in host defense post-BMT is also marked by diminished alveolar macrophage (AM) phagocytosis, bacterial killing, and production of TNF-α and cysteinyl leukotrienes. However, a mechanism by which overproduction of PGE2 suppresses pulmonary host defense post-BMT is unknown. As IL-1R–associated kinase (IRAK)-M is a known inhibitor of MyD88-dependent IL-1R/TLR signaling and macrophage function, we sought to determine whether IRAK-M is involved in PGE2-induced immunosuppression post-BMT. We found that IRAK-M expression is elevated 3.5-fold in BMT AMs relative to control AMs, and this is related to AM overproduction of PGE2. Furthermore, genetic ablation of IRAK-M in the bone marrow of BMT mice restores host defense against P. aeruginosa. Despite AM overproduction of PGE2 and elevated E prostanoid 2 receptor expression, AM phagocytosis, killing, and production of cysteinyl leukotrienes and TNF-α are restored in the absence of IRAK-M post-BMT. Also, treatment with PGE2 does not inhibit AM phagocytosis in the absence of IRAK-M. These data suggest that the absence of IRAK-M in the hematopoietic compartment post-BMT enhances pulmonary host defense and mitigates AM sensitivity to the inhibitory effects of PGE2. Therefore, strategies to limit IRAK-M elevation post-BMT may be efficacious in reducing patient susceptibility to infection.
Hemoglobin Transforms Anti-Inflammatory Salmonella typhi Virulence Polysaccharide into a TLR-2 Agonist
Authors: Garg Rohini , Qadri Ayub 
Published: May 2010

Abstract
Vi capsular polysaccharide is a major virulence determinant of the human typhoid- causing pathogen Salmonella typhi; it is absent in nontyphoidal Salmonella serovars. We show in this study that through its specific interaction with the membrane recognition complex containing the prohibitin family of molecules, Vi can inhibit the production of inflammatory cytokines from mononuclear phagocytes stimulated with Salmonella flagellin. Remarkably, Vi lost this anti-inflammatory capability and switched to a proinflammatory state when cell stimulations were performed in the presence of serum. The serum-transformed proinflammatory form of Vi induced secretion of cytokines from monocytes by specifically engaging TLR-2/TLR-1. The molecule responsible for bringing about this conversion of Vi from an anti-inflammatory to a proinflammatory form was serum-derived hemoglobin. Derivatives of Vi incapable of interacting with hemoglobin did not switch to a proinflammatory state in vitro or in vivo. These findings provide compelling evidence for a role of hemoglobin in transforming the anti-inflammatory S. typhi virulence polysaccharide into an immune activator.
Superior Antitumor Response Induced by Large Stress Protein Chaperoned Protein Antigen Compared with Peptide Antigen
Authors: Wang Xiang-Yang , Sun Xiaolei , Chen Xing , Facciponte John , Repasky Elizabeth A. , Kane John , Subjeck John R. 
Published: May 2010

Abstract
Our previous studies have demonstrated that the natural chaperone complexes of full-length tumor protein Ags (e.g., gp100) and large stress proteins (e.g., hsp110 and grp170) with exceptional Ag-holding capabilities augment potent tumor protective immunity. In this study, we assess the peptide-interacting property of these large chaperones and, for the first time, compare the immunogenicity of the recombinant chaperone vaccines targeting two forms of Ags (protein versus peptide). Both hsp110 and grp170 readily formed complexes with antigenic peptides under physiologic conditions, and the peptide association could be further stimulated by heat shock. The large chaperones displayed similar but distinct peptide-binding features compared with hsp70 and grp94/gp96. Immunization with hsp110- or grp170-tyrosinase–related protein 2 (TRP2175–192) peptide complexes effectively primed CD8+ T cells reactive with TRP2-derived, MHC class I-restricted epitope. However, the tumor protective effect elicited by the TRP2175–192 peptide vaccine was much weaker than that achieved by full-length TRP2 protein Ag chaperoned by grp170. Furthermore, immunization with combined chaperone vaccines directed against two melanoma protein Ags (i.e., gp100 and TRP2) significantly improved overall anti-tumor efficacy when compared with either of the single Ag vaccine. Lastly, treatment of tumor-bearing mice with these dual Ag-targeted chaperone complexes resulted in an immune activation involving epitope spreading, which was associated with a strong growth inhibition of the established tumors. Our results suggest that high m.w. chaperones are superior to conventional chaperones as a vaccine platform to deliver large protein Ags, and provide a rationale for translating this recombinant chaperoning-based vaccine to future clinical investigation.
Lack of Original Antigenic Sin in Recall CD8+ T Cell Responses
Authors: Zehn Dietmar , Turner Michael J. , Lefrançois Leo , Bevan Michael J. 
Published: May 2010

Abstract
In the real world, mice and men are not immunologically naive, having been exposed to numerous antigenic challenges. Prior infections sometimes negatively impact the response to a subsequent infection. This can occur in serial infections with pathogens sharing cross-reactive Ags. At the T cell level it has been proposed that preformed memory T cells, which cross-react with low avidity to epitopes presented in subsequent infections, dampen the response of high-avidity T cells. We investigated this with a series of related MHC class-I restricted Ags expressed by bacterial and viral pathogens. In all cases, we find that high-avidity CD8+ T cell precursors, either naive or memory, massively expand in secondary cross-reactive infections to dominate the response over low-avidity memory T cells. This holds true even when &gt;10% of the CD8+ T cell compartment consists of memory T cells that cross-react weakly with the rechallenge ligand. Occasionally, memory cells generated by low-avidity stimulation in a primary infection recognize a cross-reactive epitope with high avidity and contribute positively to the response to a second infection. Taken together, our data show that the phenomenon of original antigenic sin does not occur in all heterologous infections.
Cutting Edge: A Thymocyte-Thymic Epithelial Cell Cross-Talk Dynamically Regulates Intrathymic IL-7 Expression In Vivo
Authors: Alves Nuno L. , Huntington Nicholas D. , Mention Jean-Jacques , Richard-Le Goff Odile , Di Santo James P. 
Published: May 2010

Abstract
Thymic epithelial cells (TECs) are the predominant intrathymic source of the essential thymopoietin IL-7. Whether thymocyte-TEC interactions have a role in the regulation of IL-7 expression is not known. By exploiting IL-7 reporter mice in which yellow fluorescent protein expression identifies TECs expressing high levels of IL-7 (Il7+ TECs), we show that Il7+ TECs segregate from emerging medullary TECs during thymic organogenesis. Although Il7+ TECs normally diminish with age, we found that Il7+ TECs are markedly retained in alymphoid Rag2−/−Il2rg−/− IL-7 reporter mice that manifest a profound thymopoietic arrest. Transfer of Tcra−/− or wild-type (but not Rag2−/−) hematopoietic progenitors to alymphoid IL-7 reporter recipients normalizes the frequency of Il7+ TECs and re-establishes cortical TEC/medullary TEC segregation. Although thymocyte-derived signals are often considered stimulatory for TEC maturation, our findings identify a negative feedback mechanism in which signals derived from TCRβ-selected thymocytes modulate TEC-dependent IL-7 expression.
Multifunctional Mesoporous Silica Material Used for Detection and Adsorption of Cu2+ in Aqueous Solution and Biological Applications in vitro and in vivo
Authors: Meng Qingtao , Zhang Xiaolin , He Cheng , He Guangjie , Zhou Peng , Duan Chunying 
Published: May 2010

AbstractAn inorganic–organic silica material (SBA–P2), prepared by immobilization of the 1,8‐naphthalimide‐based receptor P2 within the channels of the mesoporous silica material SBA‐15, is characterized by transmission electron microscopy and several spectroscopic methods. SBA–P2 features a high affinity Cu2+‐specific fluorescence response in aqueous solution with a detection limit for Cu2+ of ca. 0.65 ppb (10 × 10−9 M) under optimized conditions. It can extract Cu2+ from the solution with only trace amounts remaining. Through isolating of the toxic ions within the mesopores of the silica, SBA–P2 has the potential to work as a toxicide for Cu2+ in living systems. The fluorogenical responses are reversible and do not vary over a broad (4.0 to 9.0) pH range suitable for application under physiological conditions. The fluorescence responses of Cu2+ in vitro (human breast cancer cells) and in vivo (five‐day‐old zebrafish) demonstrate the possibility of further application in biology.
Brief communication: Identification reassessment of the isolated tooth Krapina D58 through occlusal fingerprint analysis
Authors: Fiorenza Luca , Benazzi Stefano , Tausch Jeremy , Kullmer Ottmar , Schrenk Friedemann 
Published: May 2010

AbstractHigh variability in the dentition of Homo can create uncertainties in the correct identification of isolated teeth. For instance, standard tooth identification criteria cannot determine with absolute certainty if an isolated tooth is a second or third maxillary molar. In this contribution, using occlusal fingerprint analysis, we reassess the identification of Krapina D58 (Homo neanderthalensis), which is catalogued as a third maxillary molar. We have hypothesized that the presence/absence of the distal occlusal wear facets can be used to differentiate second from third maxillary molars. The results obtained confirm our hypothesis, showing a significant difference between second and third maxillary molars. In particular we note the complete absence of Facets 7 and 10 in all third molars included in this analysis. The presence of these facets in Krapina D58 eliminates the possibility that it is a third maxillary molar. Consequently it should be reclassified as a second molar. Although this method is limited by the degree of dental wear (i.e., unworn teeth cannot be analyzed) and to individual molars in full occlusion, it can be used for tooth identification when other common criteria are not sufficient to discriminate between second and third maxillary molars. Am J Phys Anthropol 143:306–312, 2010. © 2010 Wiley‐Liss, Inc.
Catalysis investigation of PET depolymerization under metal oxides by microwave irradiation
Authors: Song Xiaofang , Zhang Shuzhen , Zhang Dong 
Published: May 2010

AbstractGrain poly(ethylene terephthalate) (PET) was depolymerized in pure water by different metal oxides, respectively. The catalytic hydrolysis product of terephthalic acid (TPA) obtained was the same with the no catalytic reaction. The depolymerization rate of PET was seriously influenced of the reaction time and temperature. Especially using stannous oxides as catalyst, with a reaction time of 210 min, a temperature of 200°C and a pressure of 200 psi, the depolymerization rate of PET increased from 59.3 to 90.9% compared with the no catalytic reaction. The morphology of the solid residue indicated that the depolymerization took place on the external surface of the PET grain in the presence of stannous oxide. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Curing mechanisms and kinetic analysis of DGEBA cured with a novel imidazole derivative curing agent using DSC techniques
Authors: Liu Li , Li Ming 
Published: May 2010

AbstractA novel imidazole derivative, 2MI‐g‐CA, was obtained through the reaction of 2‐methylimidazole (2MI) and cyanuric acid (CA) and characterized by means of elemental analysis, FTIR spectroscopy, 1H NMR spectroscopy, and mass spectrometric analysis. The curing mechanisms and kinetics of diglycidyl ether of bisphenol A (DGEBA) using 2MI and 2MI‐g‐CA as curing agents were studied with differential scanning calorimetry (DSC) under dynamic and isothermal conditions. Both dynamic and isothermal DSC thermograms of DGEBA/2MI system showed two distinct exothermic peaks, whereas those of DGEBA/2MI‐g‐CA system showed only one distinct exothermic peak. These results indicated that the two systems have different initiation curing mechanisms. The apparent activation energies (Ea) obtained from DSC scanning runs using the Kissinger and Ozawa methods were 79.0, 83.0 kJ/mol and 84.2, 88.8 kJ/mol for DGEBA/2MI and DGEBA/2MI‐g‐CA systems, respectively. These values suggested the novel curing agent 2MI‐g‐CA exhibited greater levels of latency during cure or increased the pot life of epoxy resin system. In addition, under the same curing condition, the Tg values of DGEBA/2MI‐g‐CA system were about 25°C higher than those of DGEBA/2MI system, exhibiting a better thermal stability. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010