bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative leaf anatomy of some endemic <i>Crocus</i> L. taxa from Turkey
Authors: Kandemir Nezahat 
Published: February 2012

Relationships among 14 Crocus L. taxa such as, C. ancyrensis (Herbert) Maw, C. baytopiorum Mathew, C. biflorus Miller ssp. crewei (Hook.) Mathew, C. biflorus ssp. isauricus (Siehe ex Bowles) Mathew, C. biflorus ssp. nubigena (Herbert) Mathew, C. biflorus ssp. pseudonubigena Mathew, C. cancellatus Herbert ssp. cancellatus, C. cancellatus ssp. damascenus (Herb ert) Mathew, C. cancellatus ssp. lycius Mathew, C. cancellatus ssp. mazziaricus (Herbert) Mathew, C. cancellatus ssp. pamphylicus Mathew, C. pestalozzae Boiss., C. reticulatus Steven ex Adams ssp. hittiticus (T. Baytop & Mathew) Mathew and C. sieheanus Barr ex Burtt collected from different two locations of Turkey have been investigated using 11 anatomic leaves characters. These taxa are endemic (except ssp. damascenus) and rare in Turkey. The anatomical variations in the cross sections of the leaf parts of the taxa were ascertained by statistical methods. It appears that the length and breadth measurements of palisade and spongy parenchyma cells, trachea diameter and cuticle thickness are important leaf anatomical characters that show variation in relation to altitudes. Key words: Crocus; Endemic; Leaf anatomy; Relationships DOI: http://dx.doi.org/10.3329/bjb.v40i2.9771 Bangladesh J. Bot. 40(2): 155-162, 2011 (December)
Genetic variability of <i>Colocasia esculenta</i> (L.) Schott.
Authors: Paul KK , Bari MA , Debnath SC 
Published: February 2012

Studies on the nature and extent of variability of aqua edible aroids cultivars, Colocasia esculenta (L.) Schott. revealed significant differences and wide range of variations among the accessions and cultivars. Genotypic variances and coefficient of variation for most of the characters were remarkably higher than their corresponding variances due to environment which also indicate the existence of variation in genotypic origin. Plant height, petiole length, leaf length, each stolon weight, total stolon weight, stolon length and corm length expressed high heritability with moderate to high genetic advance signaled heritable in nature. Key words: Genetic variability; Heritability; Colocasia esculenta; Genetic advance DOI: http://dx.doi.org/10.3329/bjb.v40i2.9775 Bangladesh J. Bot. 40(2): 185-188, 2011 (December)
Health Services Research Evaluation Principles
Authors: Crawford P. R. , Lehmann H. P. , Sockolow P. S. 
Published: February 2012

SummaryBackground: Our forthcoming national experiment in increased health information technology (HIT) adoption funded by the American Recovery and Reinvestment Act of 2009 will require a comprehensive approach to evaluating HIT. The quality of evaluation studies of HIT to date reveals a need for broader evaluation frameworks that limits the generalizability of findings and the depth of lessons learned.Objective: Develop an informatics evaluation framework for health information technology (HIT) integrating components of health services research (HSR) evaluation and informatics evaluation to address identified shortcomings in available HIT evaluation frameworks.Method: A systematic literature review updated and expanded the exhaustive review by Ammenwerth and deKeizer (AdK). From retained studies, criteria were elicited and organized into classes within a framework. The resulting Health Information Technology Research-based Evaluation Framework (HITREF) was used to guide clinician satisfaction survey construction, multi-dimensional analysis of data, and interpretation of findings in an evaluation of a vanguard community health care EHR.Results: The updated review identified 128 electronic health record (EHR) evaluation studies and seven evaluation criteria not in AdK: EHR Selection/Development/Training; Patient Privacy Concerns; Unintended Consequences/ Benefits; Functionality; Patient Satisfaction with EHR; Barriers/Facilitators to Adoption; and Patient Satisfaction with Care. HITREF was used productively and was a complete evaluation framework which included all themes that emerged.Conclusions: We can recommend to future EHR evaluators that they consider adding a complete, research-based HIT evaluation framework, such as HITREF, to their evaluation tools suite to monitor HIT challenges as the federal government strives to increase HIT adoption.
Du pain pour les chômeurs, des roses pour les enfants
Authors: Murard Lion , Zylberman Patrick 
Published: February 2012

Résumé Layettes, crèches, pouponnières, écoles de plein air et colonies de vacances... il n’est pas de municipalité de banlieue qui, telle la Suresnes de Henri Sellier, ne se présente dans l’entre-deux-guerres comme la municipalité des enfants. Ce qui se conçoit, à l’heure où la Caisse d’Assurances Sociales de la Seine et Seine-et-Oise découvre que les enfants de chômeurs envoyés en cure d’air présentent pour plus de 40 % d’entre eux une déficience avérée. Au secours de la famille, le slogan des années 30 fait la raison d’être d’une médecine des populations puisée tant au référent soviétique qu’au Service social américain, à la Vienne rouge et à l’Allemagne social-démocrate.
Cellular and Molecular Requirements for Rejection of B16 Melanoma in the Setting of Regulatory T Cell Depletion and Homeostatic Proliferation
Authors: Kline Justin , Zhang Long , Battaglia Lauren , Cohen Kenneth S. , Gajewski Thomas F. 
Published: February 2012

Abstract
We have recently demonstrated that adoptive transfer of regulatory T cell-depleted polyclonal T cells into lymphopenic mice leads to rejection of B16 melanoma, which generated an opportunity to study host requirements for tumor rejection when it effectively occurred. CD8+ T cell priming and tumor rejection required tumor Ag cross-presentation, as evidenced by tumor outgrowth in Kb−/− bone marrow chimeric or B71/2−/− mice. CD4+ T cells were additionally required for optimal tumor control, although not through classical CD4 “help,” as the frequency of primed CD8+ T cells was similar in the absence of CD4+ T cells, and tumor rejection did not depend upon CD40–CD40L interactions or on IL-2 production by CD4+ T cells. Rather, CD4+ T cells appeared to act at the effector phase of tumor rejection and responded to B16-derived Ags in vitro. At the effector phase, IFN-γ production by transferred T cells, but not host cells, was necessary. IFN-γ acted either on host or tumor cells and was associated with reduced tumor vascularity. Finally, tumor rejection occurred after transfer of TNF-α, perforin, or FasL-deficient T cells. However, perforin/FasL double-knockout T cells failed to reject, arguing that the killing of B16 melanoma cells could occur either via the cytotoxic granule or Fas pathways. Collectively, these results support a model in which host tumor Ag cross-presentation primes adoptively transferred T cells, which remain functional in the setting of homeostatic proliferation and regulatory T cell depletion, and which promote tumor rejection via IFN-γ and lysis via cytotoxic granules and/or FasL.
Three Novel Acetylation Sites in the Foxp3 Transcription Factor Regulate the Suppressive Activity of Regulatory T Cells
Authors: Kwon Hye-Sook , Lim Hyung W. , Wu Jessica , Schnölzer Martina , Verdin Eric , Ott Melanie 
Published: February 2012

Abstract
The Foxp3 transcription factor is the master regulator of regulatory T cell (Treg) differentiation and function. Its activity is regulated by reversible acetylation. Using mass spectrometry of immunoprecipitated proteins, we identify three novel acetylation sites in murine Foxp3 (K31, K262, and K267) and the corresponding sites in human FOXP3 proteins. Newly raised modification-specific Abs against acetylated K31 and K267 confirm acetylation of these residues in murine Tregs. Mutant Foxp3 proteins carrying arginine substitutions at the three acetylation sites (3KR) accumulate in T cells to higher levels than wild-type Foxp3 and exert better suppressive activity in coculture experiments. Acetylation and stability of wild-type, but not mutant, Foxp3 is enhanced when cells are treated with Ex-527, an inhibitor of the NAD+-dependent deacetylase SIRT1. Treatment with Ex-527 promotes Foxp3 expression during induced Treg differentiation, enhances Foxp3 levels in natural Tregs, and prevents loss of Foxp3 expression in adoptively transferred Tregs in mice. Our data identify SIRT1 as a negative regulator of Treg function via deacetylation of three novel target sites in Foxp3. SIRT1 inhibitors strengthen the suppressive activity of Tregs and may be useful in enhancing Treg-based therapeutic approaches to autoimmune diseases or graft rejections.
Selective Dependence of H2-M3–Restricted CD8 Responses on IL-15
Authors: Müller Jürgen R. , Waldmann Thomas A. , Dubois Sigrid 
Published: February 2012

Abstract
We studied whether CD8 T cell responses that are mediated by unconventional MHC class Ib molecules are IL-15 dependent in mice. CD8+ T cell responses to Listeria monocytogenes infection that are restricted by the MHC class Ib molecule H2-M3 decreased in the absence of IL-15, whereas other primary MHC class Ib- and MHC class Ia-restricted responses were IL-15 independent. This result was confirmed in MHC class Ia-deficient mice in which IL-15 deficiency also reduced H2-M3–restricted but not all CD8 T cell responses to L. monocytogenes. IL-15 deficiency did not affect proliferation or survival of responding H2-M3–restricted CD8+ T cells, but IL-15 was necessary to detect H2-M3–restricted CD8+ T cells in naive mice. This finding suggests that these CD8+ T cells require IL-15 during development, but become IL-15 independent after activation. IL-15 was necessary for the survival of most class Ib-restricted CD8+ T cells, starting at the mature thymocyte stage in naive mice, but does not affect a distinct CD44low/CD122low subpopulation. These data suggest that the nature of the selecting MHC class Ib molecule determines whether CD8+ T cells acquire IL-15 dependence during thymic development.
The relationship between dynamic and operating capabilities as a stage-gate process: Insights from radical innovation
Authors: Newey Lance R , Verreynne Martie-Louise , Griffiths Andrew 
Published: February 2012

AbstractDynamic capabilities ‘create, extend or modify’ the firm's current operating capabilities in order to enable strategic renewal. Although widely recognized, this conceptualization of the relationship between dynamic and operating capabilities lacks empirical grounding. Using process research into the difficult radical new product development path of a new influenza drug, our data reveal that dynamic and operating capabilities have a stage-gate type relationship. We demonstrate that dynamic capabilities need to achieve certain critical outputs if successful transfer to the operating capability stage is to be reached. Furthermore progress from one stage to the next is dependent on how well dynamic capabilities co-specialize with downstream operating capabilities. This co-specialization is enabled via three processes within a dynamic capability: value network knowledge generation, value schema development and value proposition development.
The Use of Student-Directed Instruction by Middle School Band Teachers
Authors: Bazan Dale 
Published: February 2012

Abstract
The purpose of this study was to describe the teaching and learning strategies demonstrated by middle school band teachers who reported a student-directed teaching style. This study used a twostage mixed methods design prioritizing quantitative data analysis, but also collecting qualitative data in the second stage to provide a deeper perspective. In the first stage, quantitative data were gathered using a researcher-designed demographic questionnaire and Gumm's Music Teaching Style Inventory (MTSI) (2004b). From a sample of 122 middle school band teachers, 49 surveys were returned (40.2%). Stage 1 data were analyzed to determine participant teaching styles and examine relationships and differences among selected demographics and MTSI scores. In the second stage, three of the most student-directed band teachers were observed and videotaped during five rehearsals each and interviewed. Videotapes, fieldnotes, and interviews provided insight into student-directed philosophies of band teachers and teaching strategies used in band programs.
A Content Analysis of Introductory Courses in Music Education at NASM-Accredited Colleges and Universities
Authors: Mishra Jennifer , Day Kiana , Littles Dan , Vandewalker Eddie 
Published: February 2012

Abstract
The purpose of this research was to investigate the published course descriptions of introductory courses in music education at the university level. Course requirements for music education degrees were collected from 59 randomly selected, nationally accredited schools of music. Introductory courses in music education were required by 28 (47%) institutions while 25 (42%) required a more general introductory course in education with four institutions requiring both. Six (10%) of the institutions did not require a course identifiable as an introductory course. A content analysis of published course descriptions revealed three overall themes in course content: the Music Education Profession, Curriculum and Instruction, and the Music Teacher; however, there was much variability in content necessitating a fourth miscellaneous category. Education course descriptions showed similar overall themes; however, differences emerged in the type of content included within each theme.
Scalp Free Flap Reconstruction Using Anterolateral Thigh Flap Pedicle for Interposition Artery and Vein Grafts
Authors: Park Jun Hyung , Min Kyung Hee , Eun Suk Chan , Lee Jong Hoon , Hong Sung Hee , Kim Chin Whan 
Published: February 2012

We experienced satisfactory outcomes by synchronously transplanting an artery and vein using an anterolateral thigh flap pedicle between the vascular pedicle and recipient vessel of a flap for scalp reconstruction. A 45-year-old man developed a subdural hemorrhage due to a fall injury. In this patient, the right temporal cranium was missing and the patient had 4×3 cm and 6×5 cm scalp defects. We planned a scalp reconstruction using a latissimus dorsi free flap. Intraoperatively, there was a severe injury to the right superficial temporal vessel because of previous neurosurgical operations. A 15 cm long pedicle defect was needed to reach the recipient facial vessels. For the vascular graft, the descending branch of the lateral circumflex femoral artery and two venae comitantes were harvested.The flap survived well and the skin graft was successful with no notable complications. When an interposition graft is needed in the reconstruction of the head and neck region for which mobility is mandatory to a greater extent, a sufficient length of graft from an anterolateral flap pedicle could easily be harvested. Thus, this could contribute to not only resolving the disadvantages of a venous graft but also to successfully performing a vascular anastomosis.
Hand Hygiene Education Components Among First-Year Nursing Students
Authors: Chen Jing , Yang Lin , Mak Yim-Wah , O’Donoghue Margaret , Shi Chen , Tsang Hilda , Lu Shuya , Zou Jing , Qin Jing , Xie Yao Jie , Lai Timothy , Li Chen , Cao Jiannong , Pittet Didier 
Published: June 2024

ImportanceFew studies have directly and objectively measured the individual and combined effects of multifaceted hand hygiene education programs.ObjectiveTo evaluate the individual and combined immediate effects of an instructional video and hand scan images on handwashing quality, decontamination, and knowledge improvement.Design, Setting, and ParticipantsThis cluster randomized clinical trial was conducted in June to July 2023 among first-year nursing students at a university in Hong Kong. The study used an intention-to-treat analysis.InterventionHand hygiene education sessions featuring an instructional video, hand scan images, or both.Main Outcomes and MeasuresThe primary outcome was the change in residue from fluorescent lotion remaining on participants’ hands after handwashing before and after the intervention. The secondary outcomes included handwashing quality and knowledge of hand hygiene.ResultsA total of 270 of 280 students (mean [SD] age, 19 [1] years; 182 [67.4%] female) participated in the trial (96.4% participation rate). Participants were randomized to a control group (66 participants), hand scan image group (68 participants), instructional video group (67 participants), and hand scan image with instructional video group (69 participants). All intervention groups had greater reductions in residue after the intervention compared with the control group, although none reached statistical significance (hand scan image group: 3.9 [95% CI, 2.0-5.8] percentage points; instructional video group: 4.8 [95% CI, 2.9-6.7] percentage points; hand scan image with instructional video: 3.5 [95% CI, 1.6-5.4] percentage points; control group: 3.2 [95% CI, 1.3-5.2] percentage points). The instructional video group showed a significant improvement in their handwashing performance, with a higher percentage of participants correctly performing all 7 steps compared with the control group (22.4% [95% CI, 13.1% to 31.6%] vs 1.5% [−7.9% to 10.9%]; P &amp;lt; .001). Hand scan images revealed that wrists, fingertips, and finger webs were the most commonly ignored areas in handwashing.Conclusions and RelevanceIn this cluster randomized clinical trial of an education program for hand hygiene, a handwashing instructional video and hand scan images did not enhance the level of decontamination. The intervention group had improved handwashing techniques compared with the control group, a secondary outcome.Trial RegistrationClinicalTrials.gov Identifier: NCT05872581
A Multifunctional Nanostructured Hydrogel as a Platform for Deciphering Niche Interactions of Hematopoietic Stem and Progenitor Cells
Authors: Ludwig‐Husemann Anita , Schertl Peter , Shrivastava Ananya , Geckle Udo , Hafner Johanna , Schaarschmidt Frank , Willenbacher Norbert , Freudenberg Uwe , Werner Carsten , Lee‐Thedieck Cornelia 
Published: June 2024

AbstractFor over half a century, hematopoietic stem cells (HSCs) have been used for transplantation therapy to treat severe hematologic diseases. Successful outcomes depend on collecting sufficient donor HSCs as well as ensuring efficient engraftment. These processes are influenced by dynamic interactions of HSCs with the bone marrow niche, which can be revealed by artificial niche models. Here, a multifunctional nanostructured hydrogel is presented as a 2D platform to investigate how the interdependencies of cytokine binding and nanopatterned adhesive ligands influence the behavior of human hematopoietic stem and progenitor cells (HSPCs). The results indicate that the degree of HSPC polarization and motility, observed when cultured on gels presenting the chemokine SDF‐1α and a nanoscale‐defined density of a cellular (IDSP) or extracellular matrix (LDV) α4β1 integrin binding motif, are differently influenced on hydrogels functionalized with the different ligand types. Further, SDF‐1α promotes cell polarization but not motility. Strikingly, the degree of differentiation correlates negatively with the nanoparticle spacing, which determines ligand density, but only for the cellular‐derived IDSP motif. This mechanism potentially offers a means of predictably regulating early HSC fate decisions. Consequently, the innovative multifunctional hydrogel holds promise for deciphering dynamic HSPC‐niche interactions and refining transplantation therapy protocols.
A Universal Coulombic Efficiency Compensation Strategy for Zinc‐Based Flow Batteries
Authors: Huang Shiqiang , Li Mengxiao , Song Yuxi , Xi Shibo , Wu Chao , Ang Zhi Wei Javier , Wang Qing 
Published: June 2024

AbstractAlkaline zinc‐iron flow batteries (AZIFBs) are well suited for energy storage because of their good safety, high cell voltage, and low cost. However, the occurrence of irreversible anodic parasitic reactions results in a diminished coulombic efficiency (CE), unbalanced charge state of catholyte/anolyte and subsequently, a poor cycling performance. Here, a universal CE compensation strategy centered around the oxygen evolution reaction (OER) on the cathodic side, is reported. This strategy aims to equalize the charge state of the [Fe(CN)6]3‐/4−‐based catholyte and counteract pH fluctuations. The OER process can be implemented either directly on the electrode through electrochemical reaction or in an external catalytic reactor column via a redox‐mediated process. This innovative approach effectively mitigates the gradual accumulation of [Fe(CN)6]3− in discharged catholyte and [Zn(OH)4]2− in charged anolyte by consuming the extra OH− during a continuous cycling process. As a result, AZIFBs demonstrate exceptional cycling performance with an extremely low capacity fading rate of 0.0128%/day (or 0.0005%/cycle) over 600 cycles at 80% state of charge (SOC). The proposed CE compensation strategy not only provides an effective way to address the CE loss issue for AZIFBs, but also can be applied to diverse battery technologies encountering CE loss caused by water/oxygen‐induced parasitic reactions.
Non‐Metal Sulfur Doping of Indium Hydroxide Nanocube for Selectively Photocatalytic Reduction of CO2 to CH4: A “One Stone Three Birds” Strategy
Authors: Guan Qinhui , Ran Weiguang , Zhang Dapeng , Li Wenjuan , Li Na , Huang Baibiao , Yan Tingjiang 
Published: June 2024

AbstractPhotocatalytic CO2 reduction is considered as a promising strategy for CO2 utilization and producing renewable energy, however, it remains challenge in the improvement of photocatalytic performance for wide‐band‐gap photocatalyst with controllable product selectivity. Herein, the sulfur‐doped In(OH)3 (In(OH)xSy‐z) nanocubes are developed for selective photocatalytic reduction of CO2 to CH4 under simulated light irradiation. The CH4 yield of the optimal In(OH)xSy‐1.0 can be enhanced up to 39 times and the CH4 selectivity can be regulated as high as 80.75% compared to that of pristine In(OH)3. The substitution of sulfur atoms for hydroxyl groups in In(OH)3 enhances the visible light absorption capability, and further improves the hydrophilicity behavior, which promotes the H2O dissociation into protons (H*) and accelerates the dynamic proton‐feeding CO2 hydrogenation. In situ DRIFTs and DFT calculation confirm that the non‐metal sulfur sites significantly weaken the over‐potential of the H2O oxidation and prevent the formation of ·OH radicals, enabling the stabilization of *CHO intermediates and thus facilitating CH4 production. This work highlights the promotion effect of the non‐metal doping engineering on wide‐band‐gap photocatalysts for tailoring the product selectivity in photocatalytic CO2 reduction.