bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two ent‐Kaurane Diterpenoids from Rubus corchorifolius L. f.
Authors: Zhang Min , Ou Yang‐Wen , Chen Xue‐Xiang , Cao Yong , Kuang Yong , Gong Zhu‐Qing , Peng Sheng , Chen Yun‐Jiao 
Published: October 2011

AbstractA further chemical investigation of the plant Rubus corchorifolius L. f., collected in Hunan Province, afforded two new ent‐kauranoids 6 and 7. Their structures were elucidated by various spectroscopic methods.
Streptomycindole, an Indole Alkaloid from a Marine Streptomyces sp. DA22 Associated with South China Sea Sponge Craniella australiensis
Authors: Huang Xiao‐Li , Gao Yao , Xue Duo‐Qing , Liu Hai‐Li , Peng Chong‐Sheng , Zhang Feng‐Li , Li Zhi‐Yong , Guo Yue‐Wei 
Published: October 2011

AbstractA new indole alkaloid, streptomycindole (1), and a known related compound, N‐phenylacetyl‐L‐tryptophan (2), have been isolated from Streptomyces sp. DA22, associated with South China Sea sponge Craniella australiensis. Their structures were established on the basis of a combination of mass spectrometry, 1H‐ and 13C‐NMR spectroscopic analyses, and chemical methods.
A New Anthraquinone and Two New Tetrahydroanthraquinones from the Roots of Prismatomeris connata
Authors: Feng Shi‐Xiu , Hao Jing , Chen Tao , Qiu Samuel X. ;(Shengxiang) 
Published: October 2011

AbstractA new anthraquinone, 4‐hydroxy‐1,2,3‐trimethoxy‐6‐methylanthracene‐9,10‐dione (1), and two novel tetrahydroanthraquinones, prisconnatanones A and B (2 and 3, resp.), together with 15 known anthraquinones, 4–18, were isolated from the roots of Prismatomeris connata. Their structures were elucidated on the basis of spectroscopic data. Compounds 1–18 were evaluated for their cytotoxicity against A549 and LAC human cancer cell lines. Compound 2 and the anthraquinones with free OH groups exhibited activity against the test cell lines.
New Triterpenoid and Ergostane Glycosides from the Leaves of Hydrocotyle umbellata L.
Authors: Sosa Adakarleny , Rosquete Carmelo , Rojas Luis , Pouységu Laurent , Quideau Stéphane , Paululat Thomas , Mitaine‐Offer Anne‐Claire , Lacaille‐Dubois Marie‐Aleth 
Published: October 2011

AbstractTwo new triterpenoid glycosides, together with two new ergostane glycosides, umbellatosides A–D (1–4, resp.), have been isolated from the leaves of Hydrocotyle umbellata L. Their structures were established by 2D‐NMR spectroscopic techniques (1H,1H‐COSY, TOCSY, NOESY, HSQC, and HMBC) and mass spectrometry as 3β,22β‐dihydroxy‐3‐O‐[α‐L‐rhamnopyranosyl‐(1→2)‐β‐D‐glucuronopyranosyl]olean‐12‐en‐28‐oic acid 28‐O‐β‐D‐glucopyranosyl ester (1), 3‐O‐[α‐L‐rhamnopyranosyl‐(1→2)‐β‐D‐glucuronopyranosyl]oleanolic acid 28‐O‐β‐D‐glucopyranosyl ester (2), (3β,11α,26)‐ergosta‐5,24(28)‐diene‐3,11,26‐triol 3‐O‐(β‐D‐glucopyranosyl)‐11‐O‐(α‐L‐rhamnopyranosyl)‐26‐O‐β‐D‐glucopyranoside (3), and (3β,11α,21,26)‐ergosta‐5,24(28)‐diene‐3,11,21,26‐tetrol 3‐O‐(β‐D‐glucopyranosyl)‐11‐O‐(α‐L‐rhamnopyranosyl)‐26‐O‐β‐D‐glucopyranoside (4).
Two New Meroterpenes from the Mangrove Endophytic Fungus Aspergillus sp. 085241B
Authors: Song Yong‐Xiang , Qiao Li‐Tao , Wang Jia‐Jian , Zeng Hua‐Ming , She Zhi‐Gang , Miao Cheng‐Du , Hong Kui , Gu Yu‐Cheng , Liu Lan , Lin Yong‐Cheng 
Published: October 2011

AbstractTwo new meroterpenes, ‘acetoxydehydroaustin B’ (1) and ‘1,2‐dihydro‐acetoxydehydroaustin B’ (2) were isolated in the form of a mixed crystal from the mangrove endophytic fungus Aspergillus sp. 085241B. Their structures and absolute configurations were determined by extensive analysis of their spectra and X‐ray diffraction data. In a preliminary bioassay, the mixed crystal did not exhibit activities against cancer cell lines of MDA‐MB‐435, SKBR3, HepG2, HEP3B, PC‐3, and A549, as well as against α‐glucosidase and tyrosinase.
A New Peroxy‐multiflorane Triterpene Ester from the Processed Seeds of Trichosanthes kirilowii
Authors: Ma Yue‐Ping , Li Ning , Gao Jian , Fu Ke‐Ling , Qin Ying , Li Guo‐Yu , Wang Jin‐Hui 
Published: October 2011

AbstractA new peroxy‐multiflorane triterpene ester, (3α,5α,8α,20α)‐5,8‐epidioxymultiflora‐6,9(11)‐diene‐3,29‐diol 3,29‐dibenzoate (1), was isolated from the processed seeds of Trichosanthes kirilowii, together with the two known related derivatives 2 and 3, and the two known steroids 4 and 5. Compounds 2, 4, and 5 were isolated from the genus Trichosanthes for the first time. The structure of compound 1 was established by NMR, HR‐MS, and CD analyses. Compounds 1–3 were tested for their in vitro cytotoxicity against human‐tumor cell lines (Hela, HL‐60, and MCF‐7) and anti‐inflammatory activity (LPS‐induced B lymphocyte cells) with the MTT method.
Synthesis of 4,6‐Dimethyldibenzothiophene and 1,2,3,4‐Tetrahydro‐4,6‐dimethyldibenzothiophene via Tilak Annulation
Authors: Xu Xiaoying , Li Xiang , Wang Anjie , Sun Yinyong , Schweizer W. Bernd , Prins Roel 
Published: October 2011

Abstract1,2,3,4‐Tetrahydro‐4,6‐dimethyldibenzothiophene was prepared by coupling 2‐bromo‐3‐methylcyclohexanone with 2‐methylbenzenethiol and annulating the product with the aid of polyphosphoric acid. A mixture of 1,2,3,4‐tetrahydro‐4,6‐dimethyldibenzothiophene and 4,6‐dimethyldibenzothiophene was prepared by coupling 2‐bromo‐3‐methylcyclohex‐2‐en‐1‐one with 2‐methylbenzenethiol and annulating the product with the aid of polyphosphoric acid. 2‐Bromo‐3‐methylcyclohexanone was synthesized by conjugate addition of Me3Al to 2‐bromocyclohex‐2‐en‐1‐one with CuBr as catalyst and 2‐bromo‐3‐methylcyclohex‐2‐en‐1‐one by brominationelimination of 3‐methylcyclohex‐2‐en‐1‐one. 1,2,3,4,4a,9b‐Hexahydro‐4,6‐dimethyldibenzothiophene was prepared by reduction of 1,2,3,4‐tetrahydro‐4,6‐dimethyldibenzothiophene with Zn and CF3COOH.
Multiple components in serum contribute to hepatic transgene expression by lipoplex in mice
Authors: Yoshikawa Naoki , Sakamoto Keiko , Mizuno Sachiyo , Sakaguchi Junichiro , Miyamoto Hirotaka , Mine Toyoharu , Sasaki Hitoshi , Fumoto Shintaro , Nishida Koyo 
Published: October 2011

AbstractBackgroundInteraction of cationic liposome/plasmid DNA complex (lipoplex) with serum was not a limiting factor for in vivo transfection. After intraportal injection of lipoplex, hepatic transgene expression was enhanced by interaction with serum in mice. In the present study, we analyzed the mechanism of enhanced hepatic transgene expression of lipoplex by interaction with serum components.MethodsLipoplexes were incubated with several serum components for 5 min at 37 °C before administration. Transfection efficiency of lipoplexes was measured 6 h after intraportal injection of lipoplex in mice.ResultsDepletion of divalent cation from serum decreased hepatic transgene expression. The addition of calcium ion to divalent cation‐depleted serum restored transgene expression. Heat‐inactivated serum and bovine serum albumin diminished the enhancing effect of serum on hepatic transgene expression. On the other hand, removal of anionic proteins from serum using an anion‐exchanging column was critical for the enhancing effect of serum on transgene expression. Among the serum components tested, fibronectin and complement component C3 enhanced hepatic transgene expression.ConclusionsHepatic transgene expression by lipoplex was enhanced by interaction with multiple components in serum. Interaction of lipoplex with serum could be an important factor for successful in vivo gene transfer. Hence, the information obtained in the present study is valuable for the future development of effective gene carriers. Copyright © 2011 John Wiley & Sons, Ltd.
Synthesis of some new 1‐acyl‐5‐aryl‐3‐(5‐methyl‐1‐p‐tolyl‐1H‐1,2,3‐triazol‐4‐yl)‐4,5‐dihydro‐1H‐pyrazole
Authors: Dong Heng‐Shan , Wang Yan‐Fei , Shen Guo‐Liang , Quan Bin , Dong Wang‐Jun 
Published: October 2011

AbstractSome new compounds (E)‐3‐aryl‐1‐(5‐methyl‐1‐p‐tolyl‐1H‐1,2,3‐triazol‐4‐yl)‐prop‐2‐en‐1‐ones 5a–e were prepared by 1‐(5‐methyl‐1‐p‐tolyl‐1H‐1,2,3‐triazol‐4‐yl)‐ethanone and various aromatic aldehydes. Then one pot reaction was happened by compounds 5a–e with hydrazine hydrate in acetic acid or propionic acid, respectively, to give the title compounds 1acyl‐5‐aryl‐3‐(5‐methyl‐1‐p‐tolyl‐1H‐1,2,3‐triazol‐4‐yl)‐4,5‐dihydro‐1H‐pyrazoles 6a–i. All structures were established by MS, IR, CHN, 1H‐NMR and 13C‐NMR spectral data. J. Heterocyclic Chem., (2012).
Computer‐assisted patellar resection system: Development and insights
Authors: Fu Chun Kit , Wai Jeff , Lee Estee , Hutchison Carol , Myden Curtis , Batuyong Eldridge , Anglin Carolyn 
Published: October 2011

AbstractIncorrect resection of the patella during total knee arthroplasty (TKA) can lead to anterior knee pain (AKP), patellar maltracking, patellofemoral impingement, patellar fracture, component loosening, and reduced range of motion. Computer‐assisted surgery (CAS) systems for the tibia and femur improve cut accuracy, but no CAS system is available for patellar resection. We developed a system that included an optoelectronic localizer, marker arrays on the patella and instruments, and navigation software. Three users performed resections on artificial patellae mounted in a simulated surgical setup using five techniques (two CAS, three conventional), each repeated at least three times in randomized order. Computer‐assisted patellar resection produced better or equal cut symmetry compared to conventional techniques, particularly superoinferiorly. Using CAS with a sawguide produced better results than using CAS freehand with an oscillating saw. This study showed the feasibility of computer‐assisted patellar resection, which could lead to reduced pain and complications after TKA. The feedback provided could also make patellar CAS a valuable training tool. © 2011 Orthopaedic Research Society. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 30:535–540, 2012
Driving factors determining the occurrence of sodic soils in dry subhumid Mediterranean areas
Authors: Monteiro Fernando Manuel , Fonseca Maria Madalena , Madeira Manuel Armando , Herbillon Adrien J. 
Published: October 2011

AbstractAn evaluation of the factors determining the occurrence and the properties of soils with low permeability occurring in vast areas in S Portugal was carried out taking into account the terrain morphology and the geology of the region. This paper deals with the variation patterns of the physical and chemical characteristics of soils from several soil toposequences that occur under different gradient slopes and on different parent rocks. Spatial variation of soil properties mainly depends on the composition of their cation‐exchange complex, as the role of other factors, such as the mineralogy of the clay fraction, were of minor importance. There is often a stronger increment of Na and/or Mg than of Ca with depth, causing a variable degree of sodicity in some of these soils, to which waterlogging tendency of their upper horizons is related. Though the occurrence of these features is determined by the nature of the parent rock, their degree of expression varies primarily according to the topographic position of soils. Therefore, a catenary distribution including nonsodic Cambisols or Luvisols in the hillcrests and Stagnic Solonetz or Sodic Luvisols or Sodic Stagnosols in the topographic lows is common. Such soil characteristics are of utmost importance for irrigation suitability and management of these soils, and for environmental impacts assessment, as the region is vulnerable to desertification.
Selective extraction of oxygenated compounds from oregano with sub‐critical water
Authors: Missopolinou Doukeni , Tsioptsias Costas , Lambrou Charalambos , Panayiotou Costas 
Published: October 2011

AbstractBACKGROUND: The essential oil of oregano is composed of numerous substances that exhibit various properties (e.g. antioxidants). The innovative and promising method of extraction with sub‐critical water (subcH2O) has been applied to the Greek oregano.RESULTS: The sub‐critical water extraction experiments were performed at various conditions of pressure, temperature and water flow rate. Extracts collected at different extraction times were examined by gas chromatography. The oil has been processed by super‐critical carbon dioxide (scCO2) followed by steam distillation or sub‐critical water extraction. The conventional method of steam distillation was also performed. The main component of the plant is carvacrol. The favourable oxygenated compounds (carvacrol, thymol, borneol and thymoquinone) have been extracted preferentially and faster with sub‐critical water. This method was selective for thymoquinone, which was not present in the oil from steam distillation. The oil yield obtained was much higher in the case of sub‐critical water extraction compared to the one of super‐critical carbon dioxide. The latter method resulted in oil with the highest concentration in carvacrol.CONCLUSION: Compared to the classical steam distillation, the sub‐critical water extraction is superior in terms of higher yields, less energy consumption (as it was a faster process), and better composition/selectivity of the extracts controlled by the extraction parameters. Copyright © 2011 Society of Chemical Industry
Increased expression of fibroblastic growth factor receptor 2 is correlated with poor prognosis in patients with breast cancer
Authors: Sun Shanshan , Jiang Yongdong , Zhang Guoqiang , Song Hongtao , Zhang Xianyu , Zhang Youxue , Liang Xiaoshuan , Sun Qian , Pang Da 
Published: October 2011

AbstractBackground and objectivesAlthough there is growing evidence supporting the hypothesis that fibroblast growth factor receptor 2 (FGFR2) is one of the few candidate genes linked with breast cancer susceptibility, the precise role of FGFR2 protein expression in breast cancer is still unknown. Our study examines FGFR2 protein expression in breast cancer and determines its associations with clinicopathological features and survival.MethodsSpecimens from 125 invasive ductal carcinoma grade 2 (IDC2) breast cancer patients were investigated by immunohistochemistry for FGFR2 protein expression. Associations between the expression of FGFR2 and various clinicopathological features as well as survival status were studied.ResultCytoplasmic and nuclear FGFR2 were expressed in 64.8% and 56.8% of breast cancer patients, respectively. Cytoplasmic FGFR2 expression was significantly associated with tumor size and TNM stage. Furthermore, patients with high expression levels of cytoplasmic and nuclear FGFR2 showed much lower overall survival (OS) and disease‐free survival (DFS) rates than those patients with low FGFR2 expression. Cytoplasmic FGFR2 expression and lymph node metastasis were independent prognostic factors for both DFS and OS by multivariate analysis.ConclusionsHigh FGFR2 expression is correlated with poor OS and DFS in breast cancer patients. It could be a biomarker for poor prognosis. J. Surg. Oncol. 2012; 105:773–779. © 2011 Wiley Periodicals, Inc.
TS and DPD mRNA levels on formalin‐fixed paraffin‐embedded specimens as predictors for distant recurrence of rectal cancer treated with preoperative chemoradiotherapy
Authors: Tanaka Koji , Saigusa Susumu , Toiyama Yuji , Koike Yuki , Okugawa Yoshinaga , Yokoe Takeshi , Inoue Yasuhiro , Kobayashi Minako , Miki Chikao , Kusunoki Masato 
Published: October 2011

AbstractBackground and ObjectivesDistant metastatic relapse occurs in approximately 20% of rectal cancer patients treated with 5‐fluorouracil (5‐FU)‐based chemoradiotherapy (CRT) followed by surgery. This study aimed to investigate mRNA level of 5‐FU metabolizing enzymes in post‐treatment specimens and to evaluate their predictive value of distant recurrence after CRT.MethodsForty patients with rectal cancer underwent 5‐FU‐based CRT followed by surgery. After microdissection, total RNA of residual cancer was isolated from formalin‐fixed paraffin‐embedded (FFPE) specimens. Thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), thymidine phosphorylase (TP), and orotate phosphoribosyl transferase (OPRT) as 5‐FU metabolizing enzyme were measured using real‐time reverse transcription polymerase chain reaction.ResultsPatients (n = 6) who developed distant recurrence had a significantly higher TS (P = 0.01), DPD (P = 0.02), and TP (P = 0.01) levels, compared with those patients (n = 34) without recurrence. High TS, DPD, and positive lymph node metastasis (pN) were significantly poorer prognostic factors for DFS (TS: P < 0.01, DPD: P < 0.01, pN: P < 0.05).ConclusionsHigh TS and DPD mRNA levels on FFPE specimens may predict distant recurrence of rectal cancer treated with 5‐FU‐based preoperative CRT followed by surgery. Expression analysis of 5‐FU metabolizing enzyme in residual cancer may be useful for treatment stratification and clinical management in these patients. J. Surg. Oncol. 2012; 105:529–534. © 2011 Wiley Periodicals, Inc.
Dimple patterns design for different circumstances
Authors: Yu Haiwu , Huang Wei , Wang Xiaolei 
Published: October 2011

ABSTRACTThe appealing and enigmatic properties of biological surfaces inspire people that a smooth surface is not always the best. Currently, the patterns of microdimples have attracted more attentions since such closed texture cells are supposed to generate hydrodynamic pressure easily. The advanced manufacturing techniques provide precision and freedom for the fabrication of microdimples, which enables the optimisation of dimple geometry and distribution to obtain better tribological performances. Over the past decade, experiments were carried out to investigate the effects of microdimples on various materials under different operating conditions. Analytical models were established to evaluate the hydrodynamic effect of the dimple patterns. The results suggest that the design of dimple pattern following hydrodynamic principle would obtain good tribological performance under high‐speed low‐load conditions; however, for the case of low‐speed high‐load conditions, shallow and small dimples would have more obvious friction reduction effect than those designed based on hydrodynamic pressure generation. Copyright © 2011 John Wiley & Sons, Ltd.
A double‐blind, randomized, intra‐individual controlled feasibility trial comparing the use of 1,470 and 940 nm diode laser for the treatment of hyperplastic inferior nasal turbinates
Authors: Havel Miriam , Sroka Ronald , Leunig Andreas , Patel Parag , Betz Christian S. 
Published: October 2011

AbstractIntroductionVarious laser systems have been used for volume reduction of hyperplastic nasal turbinates. For endonasal application, fiber controlled diode lasers are preferred over conventional laser systems for reasons of cost and practicability. This study compares coagulative tissue effects using λ = 1,470 nm and λ = 940 nm lasers in treatment of hyperplastic inferior nasal turbinates in an intraindividual manner.MethodsTwenty patients underwent laser coagulation for hyperplastic inferior nasal turbinates in this prospective, randomized, double‐blind, clinical feasibility trial. In each case, one nasal cavity was treated using 1,470 nm laser (4–5 W power), the other one with 940 nm laser (12 W power), endoscopically controlled in noncontact mode. Clinical presentation and patients symptoms were documented preoperatively and on day 1, 3, 7, 14, and 21 postoperatively using rhinomanometry, standardized questionnaires including SNOT 20 GAV (German adapted version), and separate endoscopic examination, respectively.ResultsNo infections, hemorrhages, or other complications occurred intra‐ or postoperatively. The mean operation time was significantly shorter using the 1,470 nm diode laser as compared to the 940 nm laser. There was a significant reduction of nasal obstruction on day 21 postoperatively compared to the preoperative condition on both sides regardless of the laser system used. Evaluation of the SNOT‐Scores as assessed before and 3 weeks after surgery showed significant subjective improvements.Conclusions1,470 nm diode laser system offers an efficient method for tissue reduction in hyperplasia of inferior nasal turbinate. Compared with our standard practice (940 nm diode laser), 1,470 nm diode laser application provides an equivalent tissue reduction in shorter operation time using less total energy and a comparable relief of nasal obstruction postoperatively. Lasers Surg. Med. 43:881‐886, 2011. © 2011 Wiley Periodicals, Inc.
Preparation of Flexible and Elastic Poly(trimethylene carbonate) Structures by Stereolithography
Authors: Schüller‐Ravoo Sigrid , Feijen Jan , Grijpma Dirk W. 
Published: October 2011

Abstract3D porous and non‐porous structures are designed and prepared by stereolithography using resins based on PTMC macromers. Tough, flexible network films prepared in this manner show E moduli of ≈3.8 MPa and high elongations at break >900%; tensile strengths are ≈4.2 MPa. These values increase with increasing PTMC macromer molecular weight. To reach suitable viscosities for processing, up to 45 wt% propylene carbonate is added as non‐reactive diluent. The solid specimens have compression moduli of 3.1–4.2 MPa, similar to the values determined in tensile testing. The built porous structures show porosities of 53–66% and average pore sizes of 309–407 µm. The compression moduli of the porous structures are significantly lower than those of the solid structures.magnified image
Synthesis of Poly[(ethylene carbonate)‐co‐(ethylene oxide)] Copolymer by Phosphazene‐Catalyzed ROP
Authors: Yang Hongjun , Yan Manqing , Pispas Stergios , Zhang Guangzhao 
Published: October 2011

AbstractPoly[(ethylene carbonate)‐co‐(ethylene oxide)] is synthesized by ROP of 1,3‐dioxolan‐2‐one using 1‐tert‐butyl‐4,4,4‐tris(dimethylamino)‐2,2‐bis[tris(dimethylamino)phosphoranylidenamino]‐2Λ5,Λ5‐catenadiphosphazene as the catalyst. NMR spectroscopy shows that the copolymer chain consists of EO‐EC‐EO‐EO sequences. GPC measurements indicate a PDI of 1.43–1.66 and show that the molecular weight increases with monomer conversion. Thermal analysis demonstrates that the copolymer is amorphous with a glass transition temperature of about –42 °C and an onset decomposition temperature of about 200 °C.
Multifunctional Poly(ϵ‐caprolactone)‐Forming Networks by Diels–Alder Cycloaddition: Effect of the Adduct on the Shape‐Memory Properties
Authors: Defize Thomas , Riva Raphaël , Jérôme Christine , Alexandre Michaël 
Published: October 2011

AbstractStar‐shaped poly(ϵ‐caprolactone)s are functionalized by various dienes (furan and anthracene) and a dienophile (maleimide), and the kinetics of network formation by melt‐blending is compared for both Diels–Alder adducts. When curing at 60 °C, the anthracene–maleimide network forms more rapidly and gives rise to a more crosslinked material than with the furan–maleimide adduct. Shape‐memory properties of the networks are compared in terms of Diels–Alder adduct stability. Both materials exhibit excellent fixity and recovery ratios, but the relatively low retro Diels–Alder temperature of the furan–maleimide adduct perturbs the mechanical stability of the network during cyclic tensile testing between 0 and 60 °C, whereas the anthracene–maleimide adduct is shown to be stable up to 150 °C.
“Schizomorphic” Emulsion Copolymerization Particles
Authors: Weber Nancy , Tiersch Brigitte , Unterlass Miriam M. , Heilig Anneliese , Tauer Klaus 
Published: October 2011

AbstractCryo‐electron microscopy, atomic force microscopy, and light microscopy investigations provide experimental evidence that amphiphilic emulsion copolymerization particles change their morphology in dependence on concentration. The shape of the particles is spherical at solids content above 1%, but it changes to rod‐like, ring‐like, and web‐like structures at lower concentrations. In addition, the shape and morphology of these particles at low concentrations are not fixed but very flexible and vary with time between spheres, flexible pearl–necklace structures, and stretched rods.