bluuebunny/crossref_metadata_2025_split huggingface dataset:
Depressive symptoms among the medically hospitalized older individuals — a 1‐year follow‐up study
Authors: Helvik Anne‐Sofie , Engedal Knut , Selbæk Geir 
Published: April 2012

AimThe present follow‐up study of older medically hospitalized patients from a rural area in Norway assessed the prevalence of depressive symptoms at 1‐year follow‐up and furthermore explored whether depressive symptoms at follow‐up was associated with change in the medical, functional or emotional situation between baseline and follow‐up.MethodsA 1‐year follow‐up study included 363 (175 men) older medical inpatients with age range 65–98 (mean = 80.2; standard deviation (SD) = 7.5) years. Information was collected at baseline and follow‐up using the Hospital Anxiety and Depression scale (HAD), the Mini‐Mental State Examination, Lawton and Brody's scales for physical self‐maintenance and performance of the instrumental activities of daily living.ResultsThe prevalence of depressive symptoms, as defined by a score ≥ 8 at HAD‐D, was 10% at baseline and 7% at follow‐up. Of those with depressive symptoms at baseline, 78% had experienced remission. The incidence of depressive symptoms at follow‐up was 5%. In logistic regression analyses adjusted for age, gender, and depressive symptoms at baseline, becoming or being in need of assistance from nursing or social services (odds ratio (OR) = 8.1, 95% CI: 1.9–34.2 and OR = 4.4, 95% CI: 1.1–17.4, respectively), having a cognitive decline (OR = 1.1, 95% CI: 1.0–1.3), and exhibiting poorer physical self‐maintenance (OR = 1.2, 95% CI: 1.0–1.3), becoming vision impaired (OR = 8.3, 95% CI: 2.8–25.0), and with increased anxiety (OR = 1.2, 95% CI: 1.0–1.3) during follow‐up was associated with depressive symptoms at follow‐up.ConclusionThe 1‐year follow‐up study of older medical inpatients contributes to the research body regarding risk factors of depression in older people. Copyright © 2012 John Wiley & Sons, Ltd.
Using Atom Transfer Radical Polymerization for the Synthesis of Grafted PVDF Copolymers towards the Synthesis of Membranes
Authors: Sermili Sarit , Eisen Moris S. 
Published: April 2012

AbstractGraft copolymers of poly(vinylidene fluoride) (PVDF) with poly(3‐sulfopropyl methacrylic acid) (PVDF‐g‐PSPMA), poly(styrene‐4‐sulfonic acid) (PVDF‐g‐PSSA), and poly(dimethylaminoethyl methacrylate) (PDVFg‐PDMAEMA) were synthesized. The aforementioned grafted copolymers were prepared from the corresponding (PDVF‐g‐PSPMPS) poly(3‐sulfopropyl methacrylate potassium) and (PVDF‐g‐PSSS) poly(styrene‐4‐sulfonate sodium) salts using PVDF as a macroinitiator for atom transfer radical polymerization (ATRP). The copolymers were casted into membranes by the phase inversion method in aqueous media. The effects of polymerization time, degree of conversion, chain transfer agent (CTA) additive, crosslink process, and various solvents were investigated. The products were characterized by 1H and 13C NMR spectroscopy, IR spectroscopy, differential scanning calorimetry (DSC), and scanning electron microscopy (SEM). The maximum grafting incorporation was up to 26, 20 and 20 wt % for PSSA, PSPMA and PDMAEMA, respectively. The incorporation was reduced using a CTA additive. The most impressive feature of the graft copolymer membranes produced in this study are the improved water fluxes and polyethylene glycol (PEG) rejection properties when compared to the commercially available, pristine PVDF.
The effect of conjugated spacer on novel carbazole derivatives for dye‐sensitized solar cells: Density functional theory/time‐dependent density functional theory study
Authors: Jungsuttiwong Siriporn , Yakhanthip Thanisorn , Surakhot Yaowarat , Khunchalee Janeeya , Sudyoadsuk Taweesak , Promarak Vinich , Kungwan Nawee , Namuangruk Supawadee 
Published: April 2012

AbstractThe ground‐state structure and frontier molecular orbital of D‐π‐A organic dyes, CFT1A, CFT2A, and CFT1PA were theoretically investigated using density functional theory (DFT) on B3LYP functional with 6‐31G(d,p) basis set. The vertical excitation energies and absorption spectra were obtained using time‐dependent DFT (TD‐DFT). The adsorptions of these dyes on TiO2 anatase (101) were carried out by using a 38[TiO2] cluster model using Perdew–Burke–Ernzerhof functional with the double numerical basis set with polarization (DNP). The results showed that the introduction of thiophene–thiophene unit (T–T) as conjugated spacer in CFT2A could affect the performance of intramolecular charge transfer significantly due to the inter‐ring torsion of T–T being decreased compared with phenylene–phenylene (P–P) spacer of CFP2A in the researhcers' previous report. It was also found that increasing the number of π‐conjugated unit gradually enhanced charge separation between the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) of these dyes, leading to a high‐efficiency photocurrent generation. The HOMO–LUMO energy gaps were calculated to be 2.51, 2.37, and 2.50 eV for CFT1A, CFT2A, and CFT1PA respectively. Moreover, the calculated adsorption energies of these dyes on TiO2 cluster were ∼14 kcal/mol, implying that these dyes strongly bind to TiO2 surface. Furthermore, the electronic HOMO and LUMO shapes of all dye–TiO2 complexes exhibited injection mechanism of electron via intermolecular charge‐transfer transition. © 2012 Wiley Periodicals, Inc.
Synthesis, Crystal Structure, Antioxidation and DNA‐Binding Studies of a Zinc(II) Complex with the Bis(N‐allylbenzimidazol‐2‐ylmethyl)aniline
Authors: Wu Huilu , Liu Bin , Kou Fan , Jia Fei , Yuan Jingkun , Bai Ying 
Published: April 2012

AbstractA complex of zinc(II) picrate (pic) with bis(N‐allylbenzimidazol‐2‐ylmethyl)aniline (abba), with composition [Zn(abba)2](pic)2, was synthesized and characterized by elemental analysis, electrical conductivity, IR and UV/Vis spectral measurements. The crystal structure of the zinc(II) complex has been determined by single‐crystal X‐ray diffraction. The Zn(II) is bonded to two abba ligands through four benzimidazole nitrogen, resulting in a distorted tetrahedron geometry. The DNA‐binding properties of the ligand and the zinc(II) complex were investigated by electronic absorption, fluorescence spectra and viscosity measurements. The experimental results suggest that the zinc(II) complex binds to DNA in an intercalation mode. In addition, the ligand abba and Zn(II) complex have scavenging effects for hydroxyl radicals and the complex shows stronger scavenging effects for hydroxyl radicals than the ligand.
Surfactant Templated Silica Xerogels as Adsorbents for Rhodamine 6G
Authors: Pirzada Tahira , Shah Syed Sakhawat 
Published: April 2012

AbstractA series of silica xerogels was synthesized by using TEOS as the silica precursor and a non ionic surfactant Triton X100 (TX100) and a cationic surfactant Hexadecyltrimethylammonium Bromide (CTAB) as templates. The xerogels were synthesized through 2‐way catalysis using ultrasonic radiations for homogeneous mixing of the precursors and template. The surfactant template was later removed through calcination at 550 °C. It was found out that gels having CTAB as the template had higher surface area (612.08 m2/g) than the gels templated by TX100 (539.6 m2/g). High surface area xerogels were used in adsorption experiments for aqueous solutions of Rhodamine 6G (R6G). UV visible spectroscopy was used to find out the concentrations of dye solutions. The adsorption data of both the types of xerogels was found to follow Freundlich's adsorption model pointing towards the possibility of adsorption of the dye molecules on the heterogeneous surface of the adsorbent.
BMP‐2 but not VEGF or PDGF in fibrin matrix supports bone healing in a delayed‐union rat model
Authors: Kaipel Martin , Schützenberger Sebastian , Schultz Arthur , Ferguson James , Slezak Paul , Morton Tatjana J. , Van Griensven Martijn , Redl Heinz 
Published: April 2012

AbstractTreatment of delayed bone healing and non‐unions after fractures, osteotomies or arthrodesis still is a relevant clinical challenge. Artificially applied growth factors can increase bone healing and progressively gain importance in clinical routine. The aim of this study was to determine the effects of rhPDGF‐BB, rhVEGF‐165, and rhBMP‐2 in fibrin matrix on bone healing in a delayed‐union rat model. Thirty‐seven rats underwent a first operation where a standardized femoral critical size defect was created. A silicone spacer was implanted to impair vascularization within the defect. At 4 weeks the spacer was removed in a second operation and rhPDGF‐BB, rhVEGF‐165, or rhBMP‐2 were applied in a fibrin clot. Animals in a fourth group received a fibrin clot without growth factors. At 8 weeks fibrin bound rhBMP‐2 treated animals showed a significantly increased union rate and bone volume within the defect compared to the other groups. Single application of fibrin bound rhPDGF‐BB and rhVEGF‐165 failed to increase bone healing in our atrophic non‐union model. © 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 30:1563–1569, 2012
Water quality under intensive banana production and extensive pastureland in tropical Mexico
Authors: Aryal Deb R. , Geissen Violette , Ponce‐Mendoza Alejandro , Ramos‐Reyes Rodimiro R. , Becker Mathias 
Published: April 2012

AbstractThe effects of intensive banana production with high mineral‐fertilizer application and of extensive pastures were compared regarding water quality in a lowland region of SE Mexico. We monitored NO$ _3^- $, NO$ _2^- $, and PO43– concentrations in groundwater (80 m depth), subsurface water (5 m depth), and surface water (open‐ditch drainage) at monthly intervals for a one‐year period. Irrespective of the land use, the NO$ _3^- $ concentrations in all water bodies were lower than the threshold value for drinking water and aquatic life. Particularly in areas with intense banana production, the NO$ _2^- $ contents in water exceeded the safety thresholds for drinking water of 1.0 mg L–1 (WHO, 2006) and aquatic ecosystems of 0.2 mg L–1 (OATA, 2008). Water from pastureland showed significantly higher PO43– concentration than that from the banana plantation, indicating a high risk of eutrophication. There is a need to provide recommendations for optimal time and amount of N application in commercial banana production and for limitation of P inputs in pasturelands to avoid further contamination of water bodies.
Micro‐encapsulation of refined olive oil: influence of capsule wall components and the addition of antioxidant additives on the shelf life and chemical alteration
Authors: Calvo Patricia , Castaño Ángel Luís , Lozano Mercedes , González‐Gómez David 
Published: April 2012

AbstractBACKGROUND: Although refined olive oils (ROOs) exhibit lower quality and less stability toward thermal stress than extra‐virgin olive oils, these types of oil are gaining importance in the food industry. The inclusion of ROOs in processed food may alter the oxidative stability of the manufactured products, and therefore having technological alternatives to increase oil stability will be an important achievement. For this reason the main goal of this study was to assess the influence of the micro‐encapsulation process on the ROO chemical composition and its oxidative stability. Factors such as microcapsule wall constituents and the addition of the antioxidant butyl hydroxytoluene were investigated in order to establish the most appropriate conditions to ensure no alteration of the refined olive oil chemical characteristics.RESULTS: The optimised methodology exhibited high encapsulation yield (>98%), with micro‐encapsulation efficiency ranging from 35 to 69% according to the nature of the wall components. The encapsulation process slightly altered the chemical composition of the olive oil and protected the oxidative stability for at least 11 months when protein components were included as wall components.CONCLUSION: It was concluded that the presence of proteins constituents in the microcapsule wall material extended the shelf life of the micro‐encapsulated olive oil regardless the use of antioxidant additives. Copyright © 2012 Society of Chemical Industry
Performance analysis of flexible multirecess hydrostatic journal bearing operating with micropolar lubricant
Authors: Verma Suresh , Kumar Vijay , Gupta K. D. 
Published: April 2012

ABSTRACTThis paper presents the analytical study of the effect of the bearing shell flexibility on the performance of multirecess hydrostatic journal bearing system operating with micropolar lubricant. The modified Reynolds equation for the flow of micropolar lubricant through constant flow valve‐compensated hydrostatic journal bearing has been solved by finite element technique based on Galerkins method, and the resulting elastic deformation in the bearing shell due to fluid‐film pressure has been determined iteratively, in which the deformation coefficient accounts for the bearing shell flexibility. The computed results suggest that the influence of the micropolar effect on bearing performance characteristics is significantly affected by the bearing shell flexibility. Copyright © 2012 John Wiley & Sons, Ltd.
Nanostructure Evolution Mechanisms During Slow Load‐Cycling of Oriented HDPE/PA Microfibrillar Blends as a Function of Composition
Authors: Zeinolebadi Ahmad , Stribeck Norbert , Ganjaee‐Sari Morteza , Dencheva Nadya , Denchev Zlatan , Botta Stephan 
Published: April 2012

AbstractOriented precursors of MFCs consisting of HDPE and PA6 or PA12 are studied during strain‐controlled slow load‐cycling. In the PA6‐containing blends a strongly retarded nanostrain response is detected. Compatibilization induces nanostrain heterogenization. Stress fatigue is lower in the PA12 blends, but hardly decreased by the compatibilizer. Selective migration of the compatibilizer into a disordered semi‐crystalline fraction of the HDPE matrix can explain the findings. The semi‐crystalline HDPE entities in PA6 blends appear more disordered than in PA12‐blends. An analysis of the HDPE nanostructure evolution during cycling reveals epitaxial strain crystallization. Uncompatibilized PA6 blends cycled about high pre‐strain show plastic flow but nanoscopic shrinkage in the semi‐crystalline stacks.magnified image
A new phenotype of brain iron accumulation with dystonia, optic atrophy, and peripheral neuropathy
Authors: Horvath Rita , Holinski‐Feder Elke , Neeve Vivienne C.M. , Pyle Angela , Griffin Helen , Ashok Deephthi , Foley Charlotte , Hudson Gavin , Rautenstrauss PhD Bernd , Nürnberg Gudrun , Nürnberg Peter , Kortler Jörg , Neitzel Birgit , Bäßmann Ingelore , Rahman Thahira , Keavney Bernard , Loughlin John , Hambleton Sophie , Schoser Benedikt , Lochmüller Hanns , Santibanez‐Koref Mauro , Chinnery Patrick F. 
Published: April 2012

AbstractBackground:Neurodegeneration with brain iron accumulation is clinically and genetically heterogeneous because of mutations in at least 7 nuclear genes.Methods:We performed homozygosity mapping and whole‐exome sequencing in 2 brothers with brain iron accumulation from a consanguineous family.Results:We identified a homozygous missense mutation in both brothers in the very recently identified chromosome 19 open‐reading frame 12 gene. The disease presented before age 10 with slowly progressive tremor, dystonia, and spasticity. Additional features were optic atrophy, peripheral neuropathy, and learning difficulties. A raised serum creatine kinase indicated neuromuscular involvement, and compensatory mitochondrial proliferation implicated mitochondrial dysfunction as a pathological mechanism.Conclusions:Further studies are needed to explore the function of the chromosome 19 open‐reading frame 12 gene, and extended genetic analysis on larger patient cohorts will provide more information about the presentation and frequency of this disease. © 2012 Movement Disorder Society
First trimester placental volume and three dimensional power doppler ultrasonography in type I diabetic pregnancies
Authors: Rizzo Giuseppe , Capponi Alessandra , Pietrolucci Maria Elena , Aiello Eloisa , Arduini Domenico 
Published: April 2012

ABSTRACTObjectiveThis study aimed to investigate the placental volume and three dimensional (3D) power Doppler vascularization in type I diabetic pregnancies during the first trimesterMethods3D‐power Doppler ultrasonography of the placenta was performed at 11 + 0–13 + 6 weeks in 32 pregnancies complicated by type I diabetes. Placental volume, vascularization index (VI), flow index (FI), and vascularization flow index (VFI) were calculated using a standardized setting.ResultsIn nine pregnancies, a poor first trimester glycemic control was present as expressed by HbA1c levels ≥ 7%, whereas in the remaining 23 mothers, the HbA1c concentrations were <7%. No differences were found in the placental volumes of diabetic mothers when compared with reference limits. 3D Doppler placental vascular indices were significantly higher in diabetic mothers (VI delta value 0.99, p = 0.0012; FI delta value 0.64, p = 0.0008; VFI delta value 1.28, p = 0.0039) when compared with reference limits. Pregnancies with HbA1c ≥7% exhibited higher placental vascular indices when compared with diabetic mothers with better glycemic control.ConclusionsIn type I diabetic mothers, placental vascular indices are increased and these modifications are more evident in pregnancies with poor first trimester glycemic control. © 2012 John Wiley & Sons, Ltd.
An algorithm to identify preterm infants in administrative claims data
Authors: Eworuke Efe , Hampp Christian , Saidi Arwa , Winterstein Almut G. 
Published: April 2012

ABSTRACTPurposeTo develop and validate an algorithm to identify preterm infants in the absence of birth certificates within Medicaid data.MethodsMedicaid fee‐for‐service claims data from Florida (FL) and Texas (TX) were linked to vital statistics data for infants who were continuously eligible during the first 3 months following birth or died within that period. Prematurity was defined as less than 34 weeks gestational age. Using FL as exploratory dataset and vital statistics birth data as gold standard, we developed a logistic regression model from diagnostic and procedure codes commonly associated with preterm care, creating a prematurity score for each infant. A score cutoff was selected that maximized sensitivity while maintaining a positive predictive value (PPV) ≥ 90%. Confirmatory analyses were conducted in the TX datasets.ResultsThe prevalence of prematurity was 5.2% (95%CI: 5.1–5.2) and 4.5% (95%CI: 4.4–4.6) in FL and TX, respectively. Using only gestational age International Classification of Disease version 9, Clinical Modification (ICD‐9‐CM) codes (765.20–765.27) associated with inpatient claims achieved sensitivity of 25.7% (FL) and 12.5% (TX), specificity of 99.9% (FL) and (TX), and PPV of 91.7% (FL) and 84.8% (TX). The model had excellent discriminatory validity with a c‐statistic of 0.928 (95%CI: 0.925–0.931). The selected cutoff point achieved sensitivity of 52.6%, specificity of 99.8%, and PPV of 91.7% in FL. In TX, sensitivity was 46.8%, specificity was 99.9%, and PPV was 82.2%.ConclusionIdentification of prematurity based on gestational age ICD‐9‐CM codes is not sensitive. The prematurity score has superior construct validity and allows more comprehensive identification of preterm infants in the absence of birth certificates. Copyright © 2012 John Wiley & Sons, Ltd.
Synthesis and characterization of a multiarm poly(acrylic acid) star polymer for application in sustained delivery of cisplatin and a nitric oxide prodrug
Authors: Duan Shaofeng , Cai Shuang , Xie Yumei , Bagby Taryn , Ren Shenqiang , Forrest M. Laird 
Published: April 2012

AbstractFunctionalized polymeric nanocarriers have been recognized as drug delivery platforms for delivering therapeutic concentrations of chemotherapies. Of this category, star‐shaped multiarm polymers are emerging candidates for targeted delivery of anticancer drugs, due to their compact structure, narrow size distribution, large surface area, and high water solubility. In this study, we synthesized a multiarm poly(acrylic acid) star polymer via macromolecular design via the interchange (MADIX)/reversible addition fragmentation chain transfer (MADIX/RAFT) polymerization and characterized it using nuclear magnetic resonance (NMR) and size exclusion chromatography. The poly(acrylic acid) star polymer demonstrated excellent water solubility and extremely low viscosity, making it highly suited for targeted drug delivery. Subsequently, we selected a hydrophilic drug, cisplatin, and a hydrophobic nitric oxide (NO)‐donating prodrug, O2‐(2,4‐dinitrophenyl) 1‐[4‐(2‐hydroxy)ethyl]‐3‐methylpiperazin‐1‐yl]diazen‐1‐ium‐1,2‐diolate, as two model compounds to evaluate the feasibility of using poly(acrylic acid) star polymers for the delivery of chemotherapeutics. After synthesizing and characterizing two poly(acrylic acid) star polymer‐based nanoconjugates, poly(acrylic acid)–cisplatin (acid–Pt) and poly(acrylic acid–NO (acid–NO) prodrug, the in vitro drug release kinetics of both the acid–Pt and the acid–NO were determined at physiological conditions. In summary, we have designed and evaluated a polymeric nanocarrier for sustained‐delivery of chemotherapies, either as a single treatment or a combination therapy regimen. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012
Unitary perturbation theory applied to multiconfigurational reference functions
Authors: Nagy Péter R. , Szabados Ágnes 
Published: April 2012

AbstractUnitary parametrization of the wave operator in the form suggested by Mayer is studied in the multireference framework. The investigated unitary perturbation theory (UPT) constructs a first correction in terms of the functions having nonzero interaction with the reference state via the Hamiltonian. Parameters in the exponential of the wave operator are determined by two dimensional eigenvalue equations. Because of the unitary mapping, UPT is unaffected by the quasi‐degeneracy problem, making it an ideal tool for correcting multireference starting functions. Lack of size‐consistency is however a shortcoming of the method. Applications of UPT as well as the related degeneracy‐corrected PT (DCPT) are presented on intruder prone examples like the symmetric dissociation of the water molecule, the BeH2 system and the two lowest lying states of the scandium dimer. Size consistency violation is analysed and evaluated on the example of the water dimer. Tractability of excited states by UPT is examined by computing the singlet–triplet splitting of the CH2 molecule. © 2012 Wiley Periodicals, Inc.
Stress and stem cells
Authors: Tower John 
Published: April 2012

AbstractThe unique properties and functions of stem cells make them particularly susceptible to stresses and also lead to their regulation by stress. Stem cell division must respond to the demand to replenish cells during normal tissue turnover as well as in response to damage. Oxidative stress, mechanical stress, growth factors, and cytokines signal stem cell division and differentiation. Many of the conserved pathways regulating stem cell self‐renewal and differentiation are also stress‐response pathways. The long life span and division potential of stem cells create a propensity for transformation (cancer) and specific stress responses such as apoptosis and senescence act as antitumor mechanisms. Quiescence regulated by CDK inhibitors and a hypoxic niche regulated by FOXO transcription factor function to reduce stress for several types of stem cells to facilitate long‐term maintenance. Aging is a particularly relevant stress for stem cells, because repeated demands on stem cell function over the life span can have cumulative cell‐autonomous effects including epigenetic dysregulation, mutations, and telomere erosion. In addition, aging of the organism impairs function of the stem cell niche and systemic signals, including chronic inflammation and oxidative stress. WIREs Dev Biol 2012 doi: 10.1002/wdev.56This article is categorized under:

Adult Stem Cells, Tissue Renewal, and Regeneration > Stem Cells and Disease
Adult Stem Cells, Tissue Renewal, and Regeneration > Environmental Control of Stem Cells
Adult Stem Cells, Tissue Renewal, and Regeneration > Stem Cells and Aging