bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical management of typical and atypical carcinoids/neuroendocrine tumors in ENETS centres of excellence (CoE): Survey from the ENETS lung NET task force
Authors: Koumarianou Anna , Filosso Pier Luigi , Bodei Lisa , Castano Justo P. , Fernandez‐Cuesta Lynnette , Deroose Christophe M. , Foll Matthieu , Dromain Clarisse , Reed Nicholas Simon , Caplin Martyn , Capdevila Jaume , Falkerby Jenny , Faggiano Antongiulio , Frilling Andrea , Grande Enrique , Hicks Rodney J. , Kasajima Atsuko , Kos‐Kudla Beata , Krishna B. A. , Lim Eric , Rinke Anja , Singh Simron , Thirlwell Chrissie , Volante Marco , Walter Thomas 
Published: May 2024

AbstractLung carcinoid tumours are neuroendocrine neoplasms originating from the bronchopulmonary tract's neuroendocrine cells, accounting for only 1%–3% of all lung cancers but 30% of all neuroendocrine tumours. The incidence of lung carcinoids, both typical and atypical, has been increasing over the years due to improved diagnostic methods and increased awareness among clinicians and pathologists. The most recent WHO classification includes a subgroup of lung carcinoids with atypical morphology and higher mitotic count and/or Ki67 labelling index. Despite appropriate surgery, the 5‐year survival rate for atypical carcinoids barely exceeds 50%–70%. The role of adjuvant therapy in lung carcinoids is not well‐defined, and clinical decisions are generally based on the presence of high‐risk features. Long‐term follow‐up is essential to monitor for recurrence, although the optimal follow‐up protocol remains unclear. To address the lack of consensus in clinical management decisions, the European Neuroendocrine Tumor Society (ENETS) initiated a survey among 20 expert centres. The survey identified varied opinions on approaches to imaging, surgery, use of adjuvant therapy, and follow‐up protocols. Notably, the absence of dedicated multidisciplinary lung neuroendocrine tumour boards in some centres was evident. Experts agreed on the need for a prospective adjuvant trial in high‐risk patients, emphasizing the feasibility of such a study. In conclusion, the study highlights the need for a more uniform adoption of existing guidelines in the management of lung carcinoid tumours and emphasizes the importance of international collaboration to advance research and patient care. Close collaboration between healthcare providers and patients is vital for effective long‐term surveillance and management of these rare tumours.
Evaluation of the protective effect of coenzyme Q10 against x‐ray irradiation‐induced ovarian injury
Authors: Tekin Yesim Bayoglu , Tumkaya Levent , Mercantepe Tolga , Topal Zehra Suzan , Samanci Tuğba Celik , Yilmaz Hulya Kilic , Rakici Sema , Topcu Atilla 
Published: May 2024

AbstractAimThis study focused on the anti‐oxidant and anti‐apoptotic effects of CoQ10 in ovaries exposed to pelvic radiation.MethodsThirty‐two female rats were randomly assigned into four groups. Group I (control group), Group II: Only 2 Gy pelvic x‐ray irradiation (IR) was administered as a single fractioned dose. Group III: 30 mg/kg CoQ10 was administered by oral gavage +2 Gy pelvic IR. Group IV: 150 mg/kg CoQ10 was administered by oral gavage +2 Gy pelvic IR. CoQ10 treatment was started 7 days before pelvic IR and completed 7 days later. The rats in Group III and IV were treated with CoQ10 for a total of 14 days.ResultsHistopathological analysis showed severe damage to the ovarian tissue in the radiation group, while both doses of CoQ10 showed normal histological structure. Likewise, while there was a high level of staining in the IR group for necrosis and apoptosis, the CoQ10 treated ones were like the control group. Tissue Malondialdehyde (MDA) levels were like the control group in the low‐dose CoQ10 group, while the MDA levels of the high dose CoQ10 group were similar to the radiation group.ConclusionUsage of low‐dose CoQ10 has a radioprotective effect on radiation‐induced ovarian damage. Although the use of high doses is morphologically radioprotective, no antioxidative effect was observed in the biochemical evaluation.
Strategy Can No Longer Ignore Planetary Boundaries: A Call for Tackling Strategy's Ecological Fallacy
Authors: Bansal Pratima (Tima) , Durand Rodolphe , Kreutzer Markus , Kunisch Sven , McGahan Anita M. 
Published: May 2024

AbstractThe field of Strategy has its origins in Business Policy, which emphasized how firms could pursue important social aims that individuals and governments could not pursue otherwise. This emphasis shifted in the 1970s as the field turned towards economics for insights. Strategy scholars began to address how market‐ and industry‐level considerations, such as performance, price, and competition, were pursued by firms. By applying macro‐level principles and assumptions analogically to a more micro‐level of analysis, strategy scholars inadvertently committed what statisticians call an ecological fallacy. Educators and scholars in the field of Strategy started to accept the constructive consequences of growth, not only for the economy, but for every firm, without considering the implications for society and the natural environment. In so doing, Strategy scholarship inadvertently undermined its very ambition to advance social aims. Our Point advocates for reconsideration of the field's foundations so as to remediate the ecological fallacy and to address the climate and biodiversity crises. The goal is to offer a brighter and more relevant future for our discipline.
Deep learning for temporomandibular joint arthropathies: A systematic review and meta‐analysis
Authors: Rokhshad Rata , Mohammad‐Rahimi Hossein , Sohrabniya Fatemeh , Jafari Bahare , Shobeiri Parnian , Tsolakis Ioannis A. , Ourang Seyed AmirHossein , Sultan Ahmed S. , Khawaja Shehryar Nasir , Bavarian Roxanne , Palomo Juan Martin 
Published: May 2024

AbstractBackground and ObjectiveThe accurate diagnosis of temporomandibular disorders continues to be a challenge, despite the existence of internationally agreed‐upon diagnostic criteria. The purpose of this study is to review applications of deep learning models in the diagnosis of temporomandibular joint arthropathies.Materials and MethodsAn electronic search was conducted on PubMed, Scopus, Embase, Google Scholar, IEEE, arXiv, and medRxiv up to June 2023. Studies that reported the efficacy (outcome) of prediction, object detection or classification of TMJ arthropathies by deep learning models (intervention) of human joint‐based or arthrogenous TMDs (population) in comparison to reference standard (comparison) were included. To evaluate the risk of bias, included studies were critically analysed using the quality assessment of diagnostic accuracy studies (QUADAS‐2). Diagnostic odds ratios (DOR) were calculated. Forrest plot and funnel plot were created using STATA 17 and MetaDiSc.ResultsFull text review was performed on 46 out of the 1056 identified studies and 21 studies met the eligibility criteria and were included in the systematic review. Four studies were graded as having a low risk of bias for all domains of QUADAS‐2. The accuracy of all included studies ranged from 74% to 100%. Sensitivity ranged from 54% to 100%, specificity: 85%–100%, Dice coefficient: 85%–98%, and AUC: 77%–99%. The datasets were then pooled based on the sensitivity, specificity, and dataset size of seven studies that qualified for meta‐analysis. The pooled sensitivity was 95% (85%–99%), specificity: 92% (86%–96%), and AUC: 97% (96%–98%). DORs were 232 (74–729). According to Deek's funnel plot and statistical evaluation (p =.49), publication bias was not present.ConclusionDeep learning models can detect TMJ arthropathies high sensitivity and specificity. Clinicians, and especially those not specialized in orofacial pain, may benefit from this methodology for assessing TMD as it facilitates a rigorous and evidence‐based framework, objective measurements, and advanced analysis techniques, ultimately enhancing diagnostic accuracy.
Nutrition and chronic musculoskeletal pain: A narrative review and directions for temporomandibular disorder research and management
Authors: Mesquita Maria Laura Marreiro , Magalhães Aghata Kelma Palacio Gomes , Nascimento Matheus Vieira , Pascoal Samuel Chillavert Dias , Pontes Karina Matthes de Freitas , Bonjardim Leonardo Rigoldi , Conti Paulo César Rodrigues , Pinto Fiamengui Lívia Maria Sales 
Published: May 2024

AbstractBackgroundRecent evidence suggests neuro‐immune mechanisms may link dietary patterns to chronic painful conditions (CPC). In the research field of oro‐facial pain (OFP), studies focuses primarily on dietary mechanical limitations due to pain and dysfunction.ObjectiveThis narrative review aimed to overview the role of nutrition on CPC, with emphasis on temporomandibular disorder (TMD), enlightening OFP researcher on dietary assessment possibilities and providing directions for studies in the field of OFP and nutrition.MethodsA PubMed database search was performed using the MeSH and non‐MeSH descriptors: “temporomandibular joint disorder”; “orofacial pain”; “musculoskeletal pain”; “chronic pain disorders”; “nutrition”; “diet”; “dietary therapy”; “dietary intake” and “inflammation”. No time restrictions were applied. Literature reviews, systematic reviews, meta‐analyses and clinical and pre‐clinical trials were included.ResultsExogenous oxidants from unhealthy dietary patterns may contribute to peripheral and central pro‐inflammatory immune signalling leading to peripheral and central sensitization. Furthermore, diets rich in bioactive compounds are suggested to contribute to pain management of CPC. High dietary intake of ultra‐processed foods impacts the quality of the diet and shows adverse health outcomes. In this context, the role of nutrition on TMD remains overlooked.ConclusionConsidering diet may influence CPC, allied with the scarcity of studies evaluating the role of nutrition on TMD, well‐designed clinical trials based on dietary assessments and measurements capable of evaluating food quality, UPF consumption and nutrient adequacy—added to serum nutrient levels evaluation—are suggested.
The influence of context on the conceptualization, measurement, and application of the concept of quality of life
Authors: Lombardi Marco , Claes Claudia , Bradley Valerie J. , Schalock Robert L. 
Published: May 2024

AbstractThe influence of context on the conceptualization, measurement, and application of the quality of life concept was acknowledged in the principles contained within the originalQuality of Life Consensus Documentpublished in 2002 and validated in 2004. Since that time, there has been a substantial increase in our understanding of both the QOL construct and the multidimensional properties of context. The purpose of this article is to report on a multi‐step process conducted in 2019 by a group of international quality of life experts to review, critique, and update where necessary the QOL principles that were originally developed in 2002. Updated principles for conceptualization, measurement, and application are provided. An understanding of the role of context on the QOL concept allows for measurement guidelines to accompany the measurement principles, an understanding of the application conditions associated with a person‐ or family‐centered approach to QOL, and implementing guidelines regarding both the development of QOL‐related policies and practices and their monitoring and evaluation.
Smokeless tobacco and periodontitis: A systematic review with meta‐analysis
Authors: Quadri Mir Faeq Ali , Kamel Ahmed M. , Nayeem Maryam , John Tenny , Thacheril Anugeetha , Tartaglia Gianluca , Tadakamadla Santosh 
Published: May 2024

AbstractAimThe present systematic review with meta‐analysis aimed to investigate the global association between smokeless tobacco (SLT) use and periodontitis, considering significant effect size variation based on the income levels of countries.MethodsWe searched seven databases to identify studies that assessed the prevalence of periodontitis in adult SLT users compared to non‐users. The quality of studies was evaluated using the 10‐item risk‐of‐bias tool, and publication bias was addressed through the trim‐and‐fill method. Sensitivity analysis utilized the leave‐one‐out approach. Meta‐analysis and meta‐regression, stratified by country income, SLT type, and smoking status, employed robust variance estimation.ResultsFrom an initial pool of 484 studies, 29 studies met the selection criteria and were subjected to qualitative synthesis. Subsequently, data from 19 studies were included in the meta‐analysis. SLT users exhibited a nearly threefold greater likelihood of periodontitis compared to non‐users (OR = 2.99; 95% CI: 2.10, 4.27; p < .01). The pooled estimate did not vary significantly based on the type of SLT used or concurrent smoking. However, the odds of periodontitis varied according to the economic level of the country; the pooled estimate was higher in high‐income countries (OR = 1.69; 95% CI: 1.20, 2.37; p < .01) and even higher in lower‐middle‐income and lower‐income countries (OR = 3.91; 95% CI: 2.66, 5.77; p < .01).ConclusionsSmokeless tobacco users have a higher likelihood of developing periodontitis. This study underscores global disparities in the SLT–periodontitis relationship, highlighting the need for targeted interventions, particularly in economically challenged areas where SLT use is largely unregulated.
High prevalence of hepatitis C virus infection among incarcerated persons: Results from the Louisiana Hepatitis C Elimination Plan's opt‐out testing program in prisons
Authors: Irvin Risha , Landry Gia , Jones Miranda R. , James Anthony , Schexnayder Jean , Rodriguez Stacye , Wendell Deborah , Barthe Kathryn , Britton Elizabeth , LeSar Kendra , Manogue Sean , Sugarman Olivia K. , Brown Cynthia , Burgess Samuel , Mehta Shruti H. , Thomas David L. , Robinson William ,   the Louisiana Hepatitis C Elimination Plan Team
Published: May 2024

AbstractIn the United States, modelling studies suggest a high prevalence of hepatitis C virus (HCV) infection in incarcerated populations. However, limited HCV testing has been conducted in prisons. Through the Louisiana Hepatitis C Elimination Plan, persons incarcerated in the eight state prisons were offered HCV testing from 20 September 2019 to 14 July 2022, and facility entry/exit HCV testing was introduced. Multivariable logistic regression was used to evaluate associations with HCV antibody (anti‐HCV) positivity and viremia. Of 17,231 persons in the eight state prisons screened for anti‐HCV, 95.1% were male, 66.7% were 30–57 years old, 3% were living with HIV, 68.2% were Black and 2904 (16.9%) were anti‐HCV positive. HCV RNA was detected in 69.3% of anti‐HCV positive individuals tested. In the multivariable model, anti‐HCV positivity was associated with older age including those 30–57 (odds ratio [OR] 3.53, 95% confidence interval [CI] 2.96–4.20) and those ≥58 (OR 10.43, 95% CI 8.66–12.55) as compared to those ≤29 years of age, living with HIV (OR 1.68, 95% CI 1.36–2.07), hepatitis B (OR 1.83, 95% CI 1.25–2.69) and syphilis (OR 1.51, 95% CI 1.23–1.86). HCV viremia was associated with male sex (OR 1.89, 95% CI 1.36–2.63) and Black race (OR 1.42, 95% CI 1.20–1.68). HCV prevalence was high in the state prisons in Louisiana compared to community estimates. To the extent that Louisiana is representative, to eliminate HCV in the United States, it will be important for incarcerated persons to have access to HCV testing and treatment.
Effects of neighbor shrub propagules and soils from shrubby patches on perennial grass germination in arid rangelands of the Patagonia Monte, Argentina
Authors: Muñoz Giovana Magali , Carrera Analía Lorena , Bertiller Mónica Beatriz , Saraví Cisneros Hebe 
Published: May 2024

AbstractQuestionDo shrubs negatively affect the germination of perennial grass species in regeneration microsites? We experimentally analyzed the effect of soils from plant patches dominated by two shrub species (Larrea divaricata and Schinus johnstonii) and their propagules on the germination of three co‐dominant herbivore‐preferred perennial grass species (Poa ligularis, Nassella tenuis and Pappostipa speciosa).LocationPatagonian Monte, Chubut Province, Argentina (42°07′ S, 64°59′ W; 43°06′ S, 65°43′ W; 42°29′ S, 66°34′ W).MethodsWe conducted two simultaneous microcosm experiments. In the first experiment, we sowed perennial grass propagules of the three species alone and combined with non‐scarified shrub propagules in Petri dishes with three substrate types (filter paper, inert soil and soil from shrub patches). In the second experiment, we sowed perennial grass propagules of each species combined with scarified and non‐scarified propagules of both shrub species in Petri dishes with soil taken from plant patches dominated by L. divaricata and by S. johnstonii. Both experiments lasted 3 months. We calculated the germination proportion and mean germination time (MGT) of propagules for each perennial grass species in each treatment.ResultsPropagules from neighboring shrubs had a clearer negative effect on grass germination compared with shrub soils. Shrub propagules negatively affected the germination proportion of P. ligularis and N. tenuis, and induced longer MGT in the three perennial grass species. The combination of S. johnstonii soil and propagules negatively affected P. ligularis and P. speciosa germination. The combination of L. divaricata soil and scarified propagules completely inhibited P. speciosa germination.ConclusionsOur results highlighted the complexity of interactions between shrubs with high phenolic contents (soils and propagules) and the germination of perennial grass species in arid environments. Schinus johnstonii soil and propagules had stronger effects on perennial grass germination than L. divaricata soil and propagules. The negative effects of shrubs on microsite quality and germination processes depended on the specific shrub/grass interaction.
French guidelines on TIPS: Indications and modalities
Authors: Larrue Hélène , Allaire Manon , Weil‐Verhoeven Delphine , Barge Sandrine , Thabut Dominique , Payance Audrey , Moga Lucile , Jézéquel Caroline , Artru Florent , Archambeaud Isabelle , Elkrief Laure , Oberti Frédéric , Roux Charles , Laleman Wim , Rudler Marika , Dharancy Sébastien , Laborde Nolwenn , Minello Anne , Mouillot Thomas , Desjonquères Elvire , Wandji Line Caroll Ntandja , Bourlière Marc , Ganne‐Carrié Nathalie , Bureau Christophe ,   for the Groupe collaboratif AFEF
Published: May 2024

AbstractTransjugular intrahepatic portosystemic shunt (TIPS) has become essential in the treatment or prevention of portal hypertension‐related complications. In the early 1990s, the primary indication was refractory bleeding. It is now proposed for the treatment of ascites for the prevention of bleeding and in patients with vascular diseases of the liver. Thus, there are a growing number of patients being treated with TIPS all over the world. The broadening of indications, the involvement of multiple stakeholders, the need for an accurate selection, the positioning in relation to transplantation and the lack of standardization in pre‐therapeutic assessment, in the procedure itself and in the follow‐up have led the board of the French Association for the Study of the Liver to establish recommendations.
Childcare, work from home and the evolution of mental health in times of COVID‐19: Evidence from the Netherlands
Authors: Siflinger Bettina , Paffenholz Michaela , Seitz Sebastian , Mendel Moritz , von Gaudecker Hans‐Martin 
Published: May 2024

AbstractWe study the co‐evolution of mental health with the most prominent risk factors associated with the COVID‐19 pandemic for the Dutch working population. We exploit data from the Longitudinal Internet Studies for the Social Sciences panel from before the pandemic and five questionnaires in its first year. We find mental health decreased sharply with the onset of the first lockdown but recovered quickly, reaching levels comparable to those a year earlier. Labor market uncertainty, perceived infection risk, and loneliness are all associated with worsening mental health. Moreover, parents of children younger than 12 experience a significant drop in mental health.
From molecules to morphology: How food supply influences the larvae of sea urchins across all levels of biological organization
Authors: Somero George N. 
Published: May 2024

An important goal of many studies in molecular ecology is to utilize molecular tools to elucidate how critical traits like metabolism and growth are affected by environmental stressors and how organisms offset these stresses by adaptive molecular‐level responses. Stress from food deprivation may be critical for early developmental stages that require a continued supply of substrates for energy metabolism and growth if development is to be completed. In a ‘From the Cover’ article in this issue of Molecular Ecology, Li et al. (2023) examined the effects of withholding food (unicellular algae) on 10 traits of larvae of the purple sea urchin (Strongylocentrotus purpuratus), ranging from the molecular level (gene expression) to morphology. Overall, this study sheds new light on the plasticity of larval development and the tight linkages that exist among traits as they respond to changes in food availability. Importantly, shifts in the sources of food utilized under different dietary treatments show the plasticity of these larvae to alter reliance on endogenous energy stores and dissolved organic matter (DOM) as algae deprivation continues. The effects of global change on the amounts and phenology of productivity in the seas make this type of integrated, multi‐level analysis an important tool for predicting the future states of marine ecosystems.
Is the supermultiplier stable?
Authors: Thompson Stephen 
Published: May 2024

AbstractSupermultiplier models, which show how autonomous demand can drive both business cycles and long‐run GDP growth, are based on a stability assumption. In this paper I look at recent efforts to justify this assumption, and argue that they are not convincing. The supermultiplier literature generally assumes that business investment reacts very slowly to changes in the state of the economy, but faster adjustment speeds are consistent with US data and can generate instability.
Obsessive‐compulsive disorder as an initial manifestation of anti‐glutamic acid decarboxylase antibody‐associated encephalitis
Authors: Yamahara Naoki , Yoshikura Nobuaki , Kimura Akio , Sakai Mayu , Yabe Daisuke , Shimohata Takayoshi 
Published: May 2024

AbstractWe present the case of a 44‐year‐old woman with type 1 diabetes and anti‐glutamic acid decarboxylase antibody (GAD‐Ab) (6100 U/mL in serum), manifesting as a one‐month history of compulsive writing in her self‐monitoring blood glucose (SMBG) diary and a one‐week history of seizures before admission. On admission, she was diagnosed with GAD‐Ab‐associated encephalitis (GAD‐AE), and compulsive writing consistent with obsessive‐compulsive disorder (OCD) caused by a repetitive and persistent urge to neutralize anxiety manifesting as clearly excessive writing. Immunotherapy, including corticosteroids, azathioprine, and intravenous immunoglobulin, improved her compulsive writing, and seizures disappeared following lacosamide treatment. Two months after discharge, compulsive writing reappeared and the patient was successfully treated with temporary immunotherapy intensification. After a stable period of 2 years, the patient died due to hypoglycemic encephalopathy. Overall, we showed that GAD‐AE may cause OCD.