bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vascular endothelial growth factor receptor‐1 in human cancer
Authors: Schwartz Jonathan D. , Rowinsky Eric K. , Youssoufian Hagop , Pytowski Bronislaw , Wu Yan 
Published: February 2010

AbstractThe human vascular endothelial growth factor receptor‐1 (VEGFR‐1, or Flt‐1) is widely expressed in normal and pathologic tissue and contributes to the pathogenesis of both neoplastic and inflammatory diseases. In human cancer, VEGFR‐1 mediated signaling is responsible for both direct tumor activation and angiogenesis. VEGFR‐1 mediated activation of nonmalignant supporting cells, particularly stromal, dendritic, hematopoietic cells, and macrophages, is also likely important for cancer pathogenesis. VEGFR‐1 is also hypothesized to enable the development of cancer metastases by means of activation and premetastatic localization in distant organs of bone marrow‐derived hematopoietic progenitor cells, which express VEGFR‐1. IMC‐18F1 is a fully human IgG1 antibody that binds to VEGFR‐1 and has been associated with the inhibition of cancer growth in multiple in vitro and human tumor xenograft models. The preliminary results of phase 1 investigations have also indicated a favorable safety profile for IMC‐18F1 at doses that confer antibody concentrations that are associated with relevant antitumor activity in preclinical models. Cancer 2010;116(4 suppl):1027–32. © 2010 American Cancer Society.
Improving the efficacy of radioimmunotherapy for non‐Hodgkin lymphomas
Authors: Palanca‐Wessels M. Corinna A. , Press Oliver W. 
Published: February 2010

AbstractApproximately 66,000 Americans develop non‐Hodgkin lymphoma (NHL) each year. Although the use of unlabeled antibodies such as rituximab has significantly improved survival when combined with standard chemotherapy regimens, approximately two‐thirds of lymphoma patients eventually develop disease recurrence and die of their disease. Novel treatments are urgently needed to cure these patients. One strategy involves the use of radiolabeled immunoconjugates that specifically localize radiation delivery to sites of lymphoma while minimizing toxicity to normal tissues. A growing number of studies support the contention that radiolabeled antibody therapy can improve overall survival of lymphoma patients and lead to durable remissions, with probable cures, in many patients. Various approaches for enhancing the effectiveness of radioimmunoconjugates have been studied, including: use in newly diagnosed lymphoma patients, combination with chemotherapy or other monoclonal antibodies, use with hematopoietic stem cell transplantation, multistep pretargeting strategies to further minimize toxicity, and simultaneous targeting of multiple B‐cell antigens. This article summarizes the current knowledge supporting the use of radioimmunotherapy, an underused but effective treatment modality in NHL patients. Cancer 2010;116(4 suppl):1126–33. © 2010 American Cancer Society.
Rationale for the application of exposure and response prevention to the treatment of anorexia nervosa
Authors: Steinglass Joanna E. , Sysko Robyn , Glasofer Deborah , Albano Anne Marie , Simpson H. Blair , Walsh B. Timothy 
Published: February 2010

AbstractObjective:Anorexia nervosa (AN) is a life threatening and difficult to treat illness with a high relapse rate. Current treatments are inadequate and new approaches to treatment are needed.Method:We review the data on anxiety in AN, the relationship between anxiety disorders and AN, and the use of Exposure and Response Prevention in treatment.Results:The overlap between AN and anxiety disorders suggest a model of AN in which baseline anxiety features yield eating related fears, avoidance behaviors, and ritualized safety behaviors that promote the underweight state and the perpetuation of the disorder. We propose an Exposure and Response Prevention treatment to prevent relapse in AN.Discussion:Overlap between AN and anxiety disorders suggests that Exposure and Response Prevention may be a new and beneficial approach to preventing relapse in individuals with AN. © 2010 by Wiley Periodicals, Inc.
Independent component analysis of erroneous and correct responses suggests online response control
Authors: Hoffmann Sven , Falkenstein Michael 
Published: February 2010

AbstractAfter errors in reaction tasks, a sharp negative wave emerges in the event‐related potential (ERP), the error (related) negativity (Ne or ERN). However, also after correct trials, an Ne‐like wave is seen, called CRN or Nc, which is much smaller than the Ne. This study tested the hypothesis whether Ne and Nc reflect the same functional process, and whether this process is linked to online response control. For this purpose, independent component analysis (ICA) was utilized with the EEG data of two types of reaction tasks: a flanker task and a mental rotation task. To control for speed‐accuracy effects, speed and accuracy instructions were balanced in a between subjects design. For both tasks ICA and dipole analysis revealed one component (Ne‐IC) explaining most of the variance for the difference between correct and erroneous trials. The Ne‐IC showed virtually the same features as the raw postresponse ERP, being larger for erroneous compared to correct trials and for the flanker than for the rotation task. In addition, it peaked earlier for corrected than for uncorrected errors. The results favor the hypothesis that Ne and Nc reflect the same process, which is modulated by response correctness and type of task. On the basis of the literature and the present results, we assume that this process induces online response control, which is much stronger in error than correct trials and with direct rather than indirect stimulus response mapping. Hum Brain Mapp, 2010. © 2010 Wiley‐Liss, Inc.
Antibacterial effects of sol‐gel‐derived bioactive glass nanoparticle on aerobic bacteria
Authors: Mortazavi V. , Nahrkhalaji M. Mehdikhani , Fathi M. H. , Mousavi S. B. , Esfahani B. Nasr 
Published: February 2010

AbstractThe aim of this work was to evaluate the antibacterial effect of bioactive glass nanopowders. The 58S, 63S, and 72S compositions were prepared via the sol‐gel technique. Characterization techniques such as X‐ray diffraction, transmission electron microscopy (TEM), Zetasizer, and X‐ray fluorescent were used. The antibacterial activity was studied using Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, and Staphylococcus aureus. Cytotoxicity of the samples was evaluated using mouse fibroblast L929 cell line. The chemical compositions of the prepared samples were as predicted, and the particle size of the samples with an amorphous structure mainly ranged over 20–90 nm. At broth concentrations below 50 mg/mL, they showed no antibacterial activity. The 58S showed the highest antibacterial activity with the minimum bactericidal concentrations of 50 and 100 mg/mL for E. coli plus S. aureus and for P. aeruginosa, respectively. The 63S exhibited bactericidal and bacteriostatic effects on E. coli and S. aureus at concentrations of 100 and 50 mg/mL, respectively, at an minimum bactericidal concentrations of 100 mg/mL. However, 72S bioactive glass nanopowder showed no antibacterial effect. They showed no cytotoxicity. It was concluded that bioactive glass nanopowders could be considered as good candidates for the treatment of oral bone defects and root canal disinfection. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res, 2010
Biodegradable poly(α‐hydroxy acid) polymer scaffolds for bone tissue engineering
Authors: Yu Nicole Y. C. , Schindeler Aaron , Little David G. , Ruys Andrew J. 
Published: February 2010

AbstractSynthetic graft materials are emerging as a viable alternative to autogenous bone graft and bone allograft for the treatment of critical‐sized bone defects. These materials can be osteoconductive but are rarely intrinsically osteogenic, although this can be greatly enhanced by the application of bone morphogenetic proteins (BMPs). This review will discuss the versatility of biodegradable poly(α‐hydroxy acids) for the delivery of BMPs for bone tissue engineering. Poly(α‐hydroxy acids) have a considerable potential for customization and adaptability via modification of design parameters, including scaffold architecture, composition, and biodegradability. Different fabrication techniques will also be discussed. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010
Combination of the Metropolis Monte Carlo and Lattice Statics method for geometry optimization of H‐(Al)‐ZSM‐5
Authors: Pongsai Suchaya 
Published: February 2010

AbstractIn this article, the combination of the Metropolis Monte Carlo and Lattice Statics (MMC‐LS) method is applied to perform the geometry optimization of crystalline aluminosilicate zeolite system in the presence of cationic species (H+), i.e., H‐(Al)‐ZSM‐5. It has been proved that the MMC‐LS method is very useful to allow H+ ions in (Al)‐ZSM‐5 extra‐framework to approach the global minimum energy sites. The crucial advantage of the combination MMC‐LS method is that, in stead of simulating over thousands random configurations via the only LS method, the only one configuration is needed for the MMC‐LS simulation to achieve the lowest energy configuration. Therefore, the calculation time can be substantially reduced via the performance of the MMC‐LS method with respect to the only LS method. The calculated results obtained from the MMC‐LS and the only LS methods have been comparatively represented in terms of the thermodynamic and structural properties. © 2010 Wiley Periodicals, Inc. J Comput Chem 2010
Asian Americans' lay beliefs about depression and professional help seeking
Authors: Wong Y. Joel , Tran Kimberly K. , Kim Seong‐Hyeon , Van Horn Kerne Valerie , Calfa Nicolina Ann 
Published: February 2010

AbstractGuided by a culturally informed illness representation self‐regulation model (CIRSRM), this study analyzed the relations among 223 Asian Americans' lay beliefs about depression, enculturation to Asian values, and their likelihood of seeking professional help for depression. Participants' lay beliefs were assessed through an analysis of written responses to open‐ended questions about depression. Enculturation as well as beliefs in biological causes, situational causes, and a short duration of depression were significantly related to the likelihood of professional help seeking. In addition, enculturation moderated the association between several lay beliefs and the endorsement of professional help seeking. The findings are discussed in light of how clinicians can incorporate mental illness lay beliefs in their work with Asian Americans. © 2010 Wiley Periodicals, Inc. J Clin Psychol 66: 317–332, 2010.
Use of chain transfer agent attached to silica particles in preparation of polystyrene‐based stationary phases
Authors: Hwang Dong Guk , Zaidi Shabi Abbas , Cheong Won Jo 
Published: February 2010

AbstractA new stationary phase has been prepared by attaching a new chain transfer agent on silica particles followed by reversible addition‐fragmentation chain transfer polymerization. Porous silica particles were reacted with 3‐chloropropyltrimethoxysilane followed by sodium diethyl dithiocarbarmate. The silica particles were then allowed to undergo radical polymerization with styrene. The phase had improved ligand morphology to show better separation performance than that of the conventional C18 phase.
Psychometric testing of the breastfeeding self‐efficacy scale‐short form in a sample of Black women in the United States
Authors: McCarter‐Spaulding Deborah E. , Dennis Cindy‐Lee 
Published: February 2010

AbstractThe benefits of breastfeeding increase with duration and exclusivity, but significant racial disparities exist in breastfeeding rates. Breastfeeding self‐efficacy, as measured by the Breastfeeding Self‐Efficacy Scale Short‐Form (BSES‐SF), is a significant predictor of breastfeeding outcomes in diverse samples. The purpose of this study was to assess the psychometric properties of the BSES‐SF in Black women in the US. The psychometric characteristics were consistent with previous studies, including internal consistency, comparison with contrasted groups, and correlation with the construct of breastfeeding network support. Breastfeeding self‐efficacy significantly predicted breastfeeding at 4 and 24 weeks postpartum. The results are consistent with previous research, and they suggest the BSES‐SF could be used to identify women at risk for prematurely discontinuing breastfeeding. © 2010 Wiley Periodicals, Inc. Res Nurs Health 33:111–119, 2010
Effect of iron nanoparticle geometry on the energetics of carbon interstititals
Authors: Tolvanen Antti , Krasheninnikov Arkady V. , Kuronen Antti , Nordlund Kai 
Published: February 2010

AbstractUnderstanding the behavior of carbon interstitial atoms in metal nanoparticles is important for a better control over carbon nanotubes growth. Using analytical‐potential atomistic simulations, we study the energetics of carbon interstitials in FCC and BCC spherical and cylindrical nano‐sized iron particles. An increase in interstitial formation enthalpy (see abstract figure) in small particles gives rise to the reduced solubility of carbon in nanoscale iron. The orientation of interstitial bonds with regard to the nanoparticle surface is shown to have substantial effect on the formation enthalpy. As the radii of the studied systems is reduced below 5 Å the behavior of the interstitial formation energetics become unsystematic. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Effects of Machilus thunbergii Sieb et Zucc on UV‐induced photoaging in hairless mice
Authors: Uhm Yoon Kyung , Jung Kyung Hee , Bu Hee‐Jung , Jung Mi Young , Lee Mu‐Hyoung , Lee Sun , Lee Sunjoo , Kim Hye Kyung , Yim Sung‐Vin 
Published: February 2010

AbstractChronic ultraviolet (UV) exposure induces photoaging and oxidative stress in the skin. We investigated whether Machilus thunbergii Sieb et Zucc (M. thunbergii) could reduce UV‐induced photoaging and oxidative stress in hairless mice. The dorsal skin of hairless mice was treated topically with M. thunbergii for 2 h prior to UV irradiation. Malondialdehyde (MDA) and superoxide dismutase (SOD) levels were then measured in skin and/or serum samples. Histological changes in the skin were assessed by hematoxylin‐eosin (HE) staining. In addition, proteomes from the skin of hairless mice in each group were analyzed. The thickness of the dorsal skin and epidermis was significantly decreased by M. thunbergii treatment. We also found that MDA levels decreased after M. thunbergii treatment and the SOD levels were increased by M. thunbergii compared with those in the UV‐only treated group. Proteomic analysis revealed 17 proteins associated with photoaging. These data indicate that M. thunbergii might have antiphotoaging effects. Copyright © 2010 John Wiley & Sons, Ltd.
Preparing for an imminent FDA Clinical Investigator inspection
Authors: Winchell T. 
Published: February 2010

AbstractThis article focuses on preparation of a Clinical Investigator site, immediately prior to FDA inspection. This process can be driven by either the Sponsor or the Clinical Investigator site, but ideally it is a combined approach involving both parties, as well as the Contract Research Organization (CRO) if one is used. This ‘last minute’ preparation task can arise at any time whereby there is some prior FDA notice of an impending inspection, which often occurs after a clinical trial has been completed, the marketing application has been submitted, the research site is notified directly and/or the Sponsor is asked for additional information concerning specific sites. The author believes that this is not the time for a Quality Assurance (QA) audit but rather a management and organizational task if intent is to prepare the research site for immediate inspection. Time can most effectively be used assuring that all records are organized, available, and instructing sites on how to effectively manage the inspectional process. Copyright © 2010 John Wiley & Sons, Ltd.
The hydrological response of heavy clay grassland soils to rainfall in south‐west England using δ2H
Authors: Granger Steven J. , Bol Roland , Meier‐Augenstein Wolfram , Leng Melanie J. , Kemp Helen F. , Heaton Tim H. E. , White Sue M. 
Published: February 2010

AbstractStable isotopes of water have been previously used in catchment studies to separate rain‐event water from pre‐event groundwater. However, there are a lack of studies at the smaller scale looking at the separation of event water from pre‐event water. This is particularly relevant for heavy clay soil systems through which the movement of water is uncertain but is thought to be rainwater‐dominated. The data presented here were collected at a rural site in the south‐west of England. The historic rainfall at the site was isotopically varied but similar to the global meteoric water line, with annual weighted means of −37‰ for δ2H and −5.7‰ for δ18O and with no seasonal variation. Drainage was sampled from the inter‐flow (surface runoff + lateral through‐flow) and drain‐flow (55 cm deep mole drains) pathways of two 1 ha lysimeters during two rainfall events, which had δ2H values of −68‰ and −92‰, respectively. The δ2H values of the lysimeter drainage water suggest that there was no contribution of event water during the first, small discharge (Q) event; however, the second larger event did show isotopic variation in δ2H values negatively related to Q indicating that rainwater was contributing to Q. A hydrograph separation indicated that only 49–58% of the inter‐flow and 18–25% of the drain‐flow consisted of event water. This was surprising given that these soil types are considered retentive of soil water. More work is needed on heavy clay soils to understand better the nature of water movement from these systems. Copyright © 2010 John Wiley & Sons, Ltd.
Bayesian network models for environmental flow decision‐making: 1. Latrobe River Australia
Authors: Shenton W. , Hart B. T. , Chan T. 
Published: February 2010

AbstractCurrent methods underpinning environmental flow (eFlow) decisions often lack transparency, do not adequately consider uncertainties and rarely include adaptive management principles. We report the development and application of an eFlow Bayesian Network (BN) model that links four flow components with an ecological model to predict the spawning and recruitment of two important native fish species, the Australian Grayling and River Blackfish, in the highly regulated and flow‐stressed lower Latrobe River in Victoria, Australia. Autumn high flows, in conjunction with low stream temperature, are critical for Grayling spawning. The BN model was used to predict the probability of spawning and recruitment of these two native fish species for four flow scenarios. Quantitative data, flow simulation models and expert judgement were used to parameterize the BN model. The model results showed clearly that currently, and into the future, there is a very low likelihood of spawning and recruitment of Australian Grayling in the lower Latrobe. River Blackfish are minimally affected by the predicted reductions in flow and increased stream temperatures. Management scenarios aimed at modifying flows and stream temperatures to increase the likelihood of successful spawning and recruitment of Australian Grayling were assessed. Self‐sustaining populations of Australian Grayling could conceivably be achieved in the upper reaches of this river if fish passage was provided through an on‐stream reservoir. A major benefit in building and applying an eFlow BN model is that it can facilitate meaningful analysis and discussion of the ecological effects of particular eFlow regimes. Copyright © 2010 John Wiley & Sons, Ltd.
Risk‐based multiobjective resource allocation in hierarchical systems with multiple decisionmakers. Part I: Theory and methodology
Authors: Yan Zhenyu , Haimes Yacov Y. 
Published: February 2010

AbstractThis paper sets forth a resource allocation process for mitigating the risks that natural disasters, accidents, or willful attacks pose to large‐scale hierarchical systems. Such systems are typically comprised of plural decisionmakers at each organizational level, each with multiple risk management objectives. In this paper, we propose a Multiobjective Multi‐Decisionmaker Resource Allocation (MOMDRA) framework to model this process; we also offer a discussion of risk modeling methods under the MOMDRA framework. Furthermore, using a Hierarchical Multiobjective (HMO) approach, this paper derives strategies for generating Pareto optimal resource allocation options for different cases of decisionmakers. An illustrative example demonstrates the effectiveness of the MOMDRA framework in risk‐based modeling and decisionmaking within large‐scale hierarchical systems. © 2010 Wiley Periodicals, Inc. Syst Eng 14: 1–16, 2011
Effect of Amnion‐Derived Cellular Cytokine Solution on Healing of Experimental Partial‐Thickness Burns
Authors: Payne Wyatt G. , Wachtel Thomas L. , Smith Charlotte A. , Uberti M. Georgina , Ko Francis , Robson Martin C. 
Published: February 2010

AbstractBackgroundAmnion‐derived multipotent progenitor (AMP) cells, unlike most stem cells, have been demonstrated to be nontumorigenic and nonimmunogenic. Amnion‐derived cellular cytokine solution (ACCS), a secreted product of AMP cells, is a cocktail of cytokines existing at physiological levels and has been used to accelerate epithelialization of experimental partial‐thickness burns.MethodsUsing modifications of Zawacki’s guinea pig partial‐thickness scald burn model, a total of 65 animals were treated with ACCS, ACCS + AMP cells, unconditioned medium (UCM) + AMP cells, or either UCM alone or saline as controls. Dosage times ranged from every other day to once a week. Percent epithelialization was serially determined from acetate wound tracings. Histology was performed on wound biopsies.ResultsACCS, UCM + AMP cells, and ACCS + AMP cells improved epithelialization compared with the two control groups (P < 0.05). When ACCS was delivered more frequently, statistically significant more rapid epithelialization occurred (P < 0.05). By day 7, all groups treated with ACCS had reached at least 90% epithelialization, whereas control groups were only 20–40% epithelialized (P < 0.05). Histology showed excellent regeneration of the epidermis with rete ridge formation. Hair growth occurred in ACCS‐treated animals but not in the control group.ConclusionsAmnion‐derived cellular cytokine solution accelerates the healing of experimental partial‐thickness burns. Based on these findings, a multicenter clinical trial is underway.