bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visible-light-driven photocatalytic degradation of doxycycline using TiO2/g-C3N4/biochar catalyst
Authors: Van Hung Nguyen , Nguyet Bui Thi Minh , Bich Nguyen Ngọc , Luon Nguyen Minh , Dao Ngoc Nhiem , Kien Nguyen Trung , Le Van Thanh Son , Tuoi Nguyen Thanh , Khieu Dinh Quang 
Published: May 2024

Abstract
TiO2/g-C3N4/biochar (TCNBC) catalysts were prepared by the hydrolysis method for the photocatalytic degradation of doxycycline antibiotic (DC), with biochar obtained from the pyrolysis of Phragmites australis. The catalysts were examined using scanning electron microscope (SEM), transmission microscopy (TEM), energy dispersive x-ray spectrometer (EDX), x-ray photoelectron spectroscopy (XPS), x-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), photoluminescence spectroscopy (PL), and ultraviolet-visible diffuse reflectance spectroscopy (UV–Vis DRS) and nitrogen adsorption/desorption. The photocatalytic activity results showed that the TCNBC catalyst exhibited higher catalytic activity than pure TiO2 or g-C3N4. Its peak catalytic activity, achieving a decomposition efficiency of 91.93% and a mineralization efficiency of 81.50%, can be attributed to the synergistic effect of biochar, TiO2, and g-C3N4. Even after four cycles of use, the catalyst still maintained relatively high activity for the degradation of DC. The photocatalytic degradation efficiency of TCNBC decreased from 91.93% to 86.30% after four recycling events.
Synthesis of Fe-doped ZnO/biochar nanocomposites for acid orange 7 photodegradation and antibacterial activity under visible light region
Authors: Nhu Nguyen Thi Huynh , Nguyet Bui Thi Minh , Bich Nguyen Ngoc , Khieu Dinh Quang , Van Hung Nguyen 
Published: May 2024

Abstract
In the present study, different molar ratios of Fe-doped ZnO/biochar (FZBC) were synthesized using a coprecipitation method. ZnO nanoparticles with a size of approximately 30 nm were well dispersed on the biochar matrix. The bandgap energy decreases from 3.11 to 3.08 eV as the Fe-ion concentration increases from 1 to 7 mol%. Photocatalytic studies demonstrated that FZBC exhibited photodegradation toward acid orange 7 (AO7). FZBC exhibited a photodegradation efficiency of AO7 at a concentration of 10 mg. L−1 (93.17%), which was nine times greater than that of pure ZnO (10.30%). Furthermore, the FZBC materials also demonstrated effective inactivation of E. coli, with an antibacterial rate reaching 98%. Overall, these materials are expected to be cost-effective and suitable for photocatalytic degradation and antibacterial activities.
Minimally Invasive Beaded Electrosurgical Dissectors, Basic Science, and Pilot Studies
Authors: Weber Taiyo C , Jewell Mark , Schulman Carl I , Morgan Jefferson , Lee Alison M , Olivier Alicia K , Swanson Elizabeth A 
Published: May 2024

Abstract

Background
Minimally invasive beaded electrosurgical dissectors (“BEED devices”) provide simultaneous sharp dissection, blunt dissection, and electrosurgical coagulation while performing 100 cm2 porcine tissue plane dissections in 0.8 to 3 min with minimal bleeding and no perforations.

Objectives
The aim of the study was to report the basic science and potential clinical applications and to video document the speed and quality of planar dissections in in vivo and ex vivo porcine models with thermal damage quantified by thermal and histopathologic measurements. Additionally, in vivo porcine specimens were followed for 90 days to show whether adverse events occurred on a gross or macroscopic basis, as evidenced by photography, videography, physical examination, and dual ultrasonography.

Methods
Ex vivo porcine models were subjected to 20, 30, and 50 W in single-stroke passages with BEED dissectors (granted FDA 510(k) clearance (K233002)) with multichannel thermocouple, 3 s delay recordation combined with matching hematoxylin and eosin (H&E) histopathology. In vivo porcine models were subjected to eight 10 × 10 cm dissections in each of 2 subjects at 20, 30, and 50 W and evaluated periodically until 90 days, wherein histopathology for H&E, collagen, and elastin was taken plus standard and Doppler ultrasounds prior to euthanasia.

Results
Five to 8 mm width dissectors were passed at 1 to 2 cm/s in ex vivo models (1-10 cm/s in vivo models) with an average temperature rise of 5°C at 50 W. Clinically evidenced seromas occurred in the undressed, unprotected wounds, and resolved well prior to 90 days, as documented by ultrasounds and histopathology.

Conclusions
In vivo and ex vivo models demonstrated thermal values that were below levels known to damage subcutaneous adipose tissue or skin. Tissue histopathology confirmed healing parameters while Doppler ultrasound demonstrated normal blood flow in posttreatment tissues.

Level of Evidence: 4
scCRT: a contrastive-based dimensionality reduction model for scRNA-seq trajectory inference
Authors: Shi Yuchen , Wan Jian , Zhang Xin , Liang Tingting , Yin Yuyu 
Published: May 2024

Abstract
Trajectory inference is a crucial task in single-cell RNA-sequencing downstream analysis, which can reveal the dynamic processes of biological development, including cell differentiation. Dimensionality reduction is an important step in the trajectory inference process. However, most existing trajectory methods rely on cell features derived from traditional dimensionality reduction methods, such as principal component analysis and uniform manifold approximation and projection. These methods are not specifically designed for trajectory inference and fail to fully leverage prior information from upstream analysis, limiting their performance. Here, we introduce scCRT, a novel dimensionality reduction model for trajectory inference. In order to utilize prior information to learn accurate cells representation, scCRT integrates two feature learning components: a cell-level pairwise module and a cluster-level contrastive module. The cell-level module focuses on learning accurate cell representations in a reduced-dimensionality space while maintaining the cell–cell positional relationships in the original space. The cluster-level contrastive module uses prior cell state information to aggregate similar cells, preventing excessive dispersion in the low-dimensional space. Experimental findings from 54 real and 81 synthetic datasets, totaling 135 datasets, highlighted the superior performance of scCRT compared with commonly used trajectory inference methods. Additionally, an ablation study revealed that both cell-level and cluster-level modules enhance the model’s ability to learn accurate cell features, facilitating cell lineage inference. The source code of scCRT is available at https://github.com/yuchen21-web/scCRT-for-scRNA-seq.
Between capitalism and socialism: Tugan-Baranovsky on cooperatives
Authors: Boianovsky Mauro , Melnik Denis 
Published: May 2024

Abstract
This paper provides a comprehensive discussion of Tugan-Baranovsky’s (1916) seminal study about the working of cooperatives in a capitalist environment, which, due to historical and linguistic circumstances, has left only a limited trace in the subsequent economic literature in the Western world. He claimed to have provided the then only full analytical and historical account of economic cooperation in its several forms, especially producer and consumer cooperatives, and their impact on their members’ welfare. It was not until the 1950s and 1960s that cooperative organisations gradually occupied again the research agenda of economists under the guise of ‘labor-managed firms’. Tugan’s treatise on cooperation has been mentioned in that literature to a limited extent only, in connection with the issue of the life-cycle of producer cooperatives. Tugan’s economic treatment of cooperatives is discussed here as part of his broader social and political views of capitalism and socialism.
Jasmonate enhances cold acclimation in jojoba by promoting flavonol synthesis
Authors: Zheng Lamei , Li Bojing , Zhang Genfa , Zhou Yijun , Gao Fei 
Published: May 2024

Abstract
Jojoba is an industrial oil crop planted in tropical arid areas, and its low-temperature sensitivity prevents its introduction into temperate areas. Studying the molecular mechanisms associated with cold acclimation in jojoba is advantageous for developing breeds with enhanced cold tolerance. In this study, metabolomic analysis revealed that various flavonols accumulate in jojoba during cold acclimation. Time-course transcriptomic analysis and weighted correlation network analysis (WGCNA) demonstrated that flavonol biosynthesis and jasmonates (JAs) signaling pathways played crucial roles in cold acclimation. Combining the biochemical and genetic analyses showed that ScMYB12 directly activated flavonol synthase gene (ScFLS). The interaction between ScMYB12 and transparent testa 8 (ScTT8) promoted the expression of ScFLS, but the negative regulator ScJAZ13 in the JA signaling pathway interacted with ScTT8 to attenuate the transcriptional activity of the ScTT8 and ScMYB12 complex, leading to the downregulation of ScFLS. Cold acclimation stimulated the production of JA in jojoba leaves, promoted the degradation of ScJAZ13, and activated the transcriptional activity of ScTT8 and ScMYB12 complexes, leading to the accumulation of flavonols. Our findings reveal the molecular mechanism of JA-mediated flavonol biosynthesis during cold acclimation in jojoba and highlight the JA pathway as a promising means for enhancing cold tolerance in breeding efforts.
Interventional heart catheterization to close atrial septal defect, patent ductus arteriosus, ventricular septal defect in a 3.5-year-old girl; a case report study
Authors: Kamiab Zahra , Derakhshan Reza 
Published: May 2024

Abstract
The aim of this study was to introduce an interventional heart catheterization to close patent ductus arteriosus (PDA), ventricular septal defect (VSD), atrial septal defect (ASD), and pulmonary hypertension without complications from open heart surgery and a 3-day hospitalization period. PDA, VSD, and ASD are among the most common abnormalities associated with various complications. This case is a 3.5-year-old girl with frequent lung infections and Failure to thrive. Treatment in the first stage aims to close the PDA using Amplatzer ADO II type AGA, size 5-6 mm and ASD using Amplatzer Septal Occluder size 15 mm. The patient was discharged the next day. Six months later, a successful interventional closure of the VSD was performed using Lifetech Symmetric Amplatzer membranous size 12 mm and patient was discharged 2 days after. All these defects were corrected without open heart surgery and the need for long-term Intensive care unitsadmission.
Unicornuate uterus with a rudimentary non-communicating cavitary horn in association with VACTERL association: a rare case report
Authors: Alsalameh Barah Khader , Eddin Bassam Ghaleb Nasser , Jobran Afnan W M 
Published: May 2024

Abstract
Mullerian anomalies are malformations that affect the embryological development of paramesonephric ducts and are associated with multiple urogenital defects due to shared embryology, including VACTERL association, which coexists in about one-third of these patients. We report a rare case of a unicornuate noncommunicating horn uterus with a rudimentary second horn in a known case of VACTERL association in a 16-year-old girl.
Rare melanosis in the urinary bladder and prostate: a case report
Authors: Tran Pierre T C , Thellman Connor J , Woolf Kirsten , Hamid Anam , Rice-Stitt Travis L 
Published: May 2024

Abstract
Melanosis, the aberrant deposition of melanin pigment in the absence of melanocytes, is very rare in the genitourinary tract. We report a case of a 74-year-old male with symptomatic benign prostatic hyperplasia. Diagnostic cystourethroscopy demonstrated bladder mucosa remarkable for numerous flat, velvety, and brown–black lesions. The patient underwent cystolitholapaxy, transurethral resection of the prostate, and bladder biopsy. Microscopic examination of the bladder biopsy demonstrated urothelium with granular, black pigmentation within the mucosa and histiocytes in the lamina propria; a Fontana Masson stain was positive for melanin. Microscopic examination of the transurethral resection of the prostate demonstrated nodular hyperplasia with focal, black pigmentation of the stroma. The rarity of bladder and prostate melanosis highlights the need for further investigation to elucidate its clinical significance and provide assurance of its benignity. Despite its rarity, melanosis should be kept in the differential diagnosis when melanotic lesions are encountered during cystoscopy.
Concomitant pancreatic and duodenal metastases 12 years after nephrectomy for renal cell carcinoma: a case report
Authors: Tanaka Hideharu , Komori Shuji , Suetsugu Tomonari , Iwata Yoshinori , Watanabe Taku , Tanaka Chihiro , Nagao Narutoshi , Noguchi Kei , Hisamatsu Kenji , Katayama Masaki , Kawai Masahiro 
Published: May 2024

Abstract
In selected patients with metastatic renal cell carcinoma, metastasectomy can achieve prolonged survival. Herein we report a patient with concomitant pancreatic and duodenal metastases occurring 12 years after total right nephrectomy for a renal cell carcinoma. The metastases were successfully treated by a pancreas-sparing duodenectomy and distal pancreatectomy. A 66-year-old man was referred to our hospital with a chief complaint of right upper abdominal pain. He had undergone laparoscopic total right nephrectomy for renal cell carcinoma 12 years before. Enhanced computed tomography showed hypervascular tumors in the pancreatic body and the descending duodenum near the papilla of Vater. Histopathological examination of endoscopic ultrasonography-guided fine needle aspiration cytology specimens revealed metastatic clear cell renal cancer. The patient underwent pancreas-sparing duodenectomy and distal pancreatectomy. He developed a pancreatic fistula after surgery that improved with conservative treatment, and has been free of evidence of recurrence up to 20 months postoperatively.
Subclavian steal syndrome: a case study of diagnosis, management, and successful surgical resolution
Authors: Mansour Marah , Raffoul Lutfallah , Alattar Omar , Deeb Hala , Albainy Laila , Taqem Saleh 
Published: May 2024

Abstract
Subclavian steal syndrome (SSS) is a rare vascular condition characterized by retrograde blood flow in the vertebral artery, often discovered incidentally in asymptomatic patients. We present a 65-year-old male with recurrent transient ischemic attacks (TIAs) attributed to 99% stenosis at the origin of the left subclavian artery, leading to SSS. Diagnostic modalities included duplex ultrasound, confirming inverted left vertebral artery flow, and multi-slice computed tomography angiography, confirming the diagnosis. Despite an unsuccessful attempt at balloon angioplasty, successful vascular surgery was performed, establishing a left carotid-vertebral artery bypass. The patient recovered well without complications. This case underscores the importance of considering SSS in TIA cases, utilizing non-invasive diagnostic tools, and highlighting the successful management of symptomatic SSS through surgical intervention.
Navigating the complexity of skull base osteomyelitis: a case study and comprehensive review
Authors: Horache Kenza , Jidal Manal , Kettani Najwa El , Fikri Meriem , Jiddane Mohamed , Touarsa Firdaous 
Published: May 2024

Abstract
Skull base osteomyelitis is a rare and life-threatening infection of the skull base, commonly seen in elderly diabetic patients as a result of otogenic or paranasal infection. The diagnosis is based on a series of arguments, including a high clinical suspicion, imaging findings, negative biopsies for malignancy, and microbiological isolation. Complications, including abscess formation and vascular involvement, mandate a multidisciplinary treatment approach, primarily involving broad-spectrum antibiotics and surgical debridement, but the prognosis is usually poor. Herein, we describe the case of a 55-year-old male, who 15 years prior, underwent radiation therapy for nasopharyngeal carcinoma. He presented with an infection of the skull base with extensive bone erosion accompanied by an uncommon complication; an intra clival abscess. Despite aggressive antibiotic therapy, the patient ultimately succumbed to septic shock.
Infectious Mediastinitis: A Retrospective Cohort Study
Authors: Lemmet Thomas , Mazzucotelli Jean-Philippe , Collange Olivier , Fath Léa , Mutter Didier , Brigand Cécile , Falcoz Pierre-Emmanuel , Danion François , Lefebvre Nicolas , Bourne-Watrin Morgane , Gerber Victor , Hoellinger Baptiste , Fabacher Thibaut , Hansmann Yves , Ruch Yvon 
Published: May 2024

Abstract

Background
This study aimed to characterize the demographics, microbiology, management and treatment outcomes of mediastinitis according to the origin of the infection.

Methods
This retrospective observational study enrolled patients who had mediastinitis diagnosed according to the criteria defined by the Centers for Disease Control and Prevention and were treated in Strasbourg University Hospital, France, between 1 January 2010 and 31 December 2020.

Results
We investigated 151 cases, including 63 cases of poststernotomy mediastinitis (PSM), 60 cases of mediastinitis due to esophageal perforation (MEP) and 17 cases of descending necrotizing mediastinitis (DNM). The mean patient age (standard deviation) was 63 (14.5) years, and 109 of 151 patients were male. Microbiological documentation varied according to the origin of the infection. When documented, PSM cases were mostly monomicrobial (36 of 53 cases [67.9%]) and involved staphylococci (36 of 53 [67.9%]), whereas MEP and DNM cases were mostly plurimicrobial (38 of 48 [79.2%] and 8 of 12 [66.7%], respectively) and involved digestive or oral flora microorganisms, respectively. The median duration of anti-infective treatment was 41 days (interquartile range, 21–56 days), and 122 of 151 patients (80.8%) benefited from early surgical management. The overall 1-year survival rate was estimated to be 64.8% (95% confidence interval, 56.6%–74.3%), but varied from 80.1% for DNM to 61.5% for MEP.

Conclusions
Mediastinitis represents a rare yet deadly infection. The present cohort study exhibited the different patterns observed according to the origin of the infection. Greater insight and knowledge on these differences may help guide the management of these complex infections, especially with respect to empirical anti-infective treatments.
Diagnostic Value of Microbial Cell-free DNA Sequencing for Suspected Invasive Fungal Infections: A Retrospective Multicenter Cohort Study
Authors: Huygens Sammy , Schauwvlieghe Alexander , Wlazlo Nick , Moors Ine , Boelens Jerina , Reynders Marijke , Chong Ga-Lai , Klaassen Corné H W , Rijnders Bart J A 
Published: May 2024

Abstract

Background
An early diagnosis and treatment of invasive fungal disease (IFD) is associated with improved outcome, but the moderate sensitivity of noninvasive diagnostic tests makes this challenging. Invasive diagnostic procedures such as bronchoalveolar lavage (BAL) have a higher yield but are not without risk. The detection and sequencing of microbial cell-free DNA (mcfDNA) may facilitate a noninvasive diagnosis.

Materials
In a prospective observational study, we collected plasma in the 120 hours preceding or following a BAL in patients with hematological malignancies suspected for a pulmonary IFD. The EORTC/MSGERC2020 criteria were used for IFD classification. Sequencing was performed by Karius (Redwood City, CA) using their Karius Test (KT) on plasma and a “research use only test” on BAL fluid if available. Cases with a probable/proven IFD were identified based on standard diagnostic tests on serum and BAL (microscopy, polymerase chain reaction, galactomannan, culture) and used to calculate the sensitivity, specificity, and additional diagnostic value of the KT.

Results
Of 106 patients enrolled, 39 (37%) had a proven/probable invasive aspergillosis, 7 (7%) a non-Aspergillus IFD, and 4 (4%) a mixed IFD. The KT detected fungal mcfDNA in 29 (28%) patients. Compared with usual diagnostic tests, the sensitivity and specificity were 44.0% (95% confidence interval [CI], 31.2–57.7) and 96.6% (95% CI, 88.5%–99.1%). Sensitivity of the KT was higher in non-Aspergillus IFD (Mucorales:2/3, Pneumocystis jirovecii: 3/5). On BAL, the sensitivity was 72.2% (95% CI, 62.1–96.3), and specificity 83.3% (95% CI, 49.1–87.5).

Conclusions
Sequencing of mcfDNA may facilitate a noninvasive diagnosis of IFD in particular non-Aspergillus IFD. However, on plasma and similar to currently available diagnostics, it cannot be used as a “rule-out” test.
Racial Disparities in Endometrial Cancer Clinical Trial Representation
Authors: Wolf Jennifer L. , Hamilton Alexandra , An Anjile , Leonard John P. , Kanis Margaux J. 
Published: May 2024

Background:
This study aimed to determine whether Black patients with recurrent endometrial cancer were more likely than White patients to be ineligible for a recently published clinical trial due to specific eligibility criteria.

Methods:
Patients with recurrent or progressive endometrial cancer diagnosed from January 2010 to December 2021 who received care at a single institution were identified. Demographic and clinicopathologic information was abstracted and determination of clinical trial eligibility was made based on 14 criteria from the KEYNOTE-775 trial. Characteristics of the eligible and ineligible cohorts were compared, and each ineligibility criterion was evaluated by race.

Results:
One hundred seventy-five patients were identified, 89 who would have met all inclusion and no exclusion criteria for KEYNOTE-775, and 86 who would have been ineligible by one or more exclusion criteria. Patients in the ineligible cohort were more likely to have lower BMI (median 26.5 vs. 29.2, P<0.001), but were otherwise similar with regard to insurance status, histology, and stage at diagnosis. Black patients had 33% lower odds of being eligible (95% CI: 0.33-1.34) and were more likely to meet the exclusion criterion of having a previous intestinal anastomosis, but the result was not statistically significant. If this criterion were removed, the racial distribution of those ineligible for the trial would be more similar (46.4% Black vs. 42.2% White).

Conclusions:
Clinical trial eligibility criteria may contribute to the underrepresentation of racial groups in clinical trials, but other factors should be explored. Studies to quantify and lessen the impact of implicit bias are also needed.