bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving stroke alert response time: Applying quality improvement methodology to the inpatient neurologic emergency
Authors: Cumbler Ethan , Zaemisch Rebekah , Graves Alexandra , Brega Kerry , Jones William 
Published: November 2011

AbstractBACKGROUND:Stroke often leaves its victims with devastating disabilities if not treated promptly. Guidelines recommend that brain imaging be obtained within 25 minutes, yet this benchmark is rarely achieved for the in‐hospital stroke.PURPOSE:To reduce time to evaluation for strokes occurring in patients already hospitalized, through systematic analysis of current processes and application of standardized quality improvement methodology.METHODS:Improving the quality of care for in‐hospital stroke patients involved 4 key steps: (1) creation of a detailed process map to identify inefficiencies in the current process for identifying and treating hospitalized stroke patients, (2) development of an optimized care pathway, (3) implementation of a checklist of optimal practices for the acute stroke response team and nursing staff, and (4) real‐time feedback. Time from stroke alert to initiation of computed tomography (CT) scan was prospectively tracked for the 6‐month period prior to intervention. After a 3‐month interval for intervention roll‐out, the response times for the pre‐intervention period were compared to a 6‐month post‐intervention evaluation period.RESULTS:Pre‐intervention median inpatient stroke alert‐to‐CT time was 69.0 minutes, with 19% meeting the goal of 25 minutes from alert to CT time. Post‐intervention median inpatient stroke alert‐to‐CT time was reduced to 29.5 minutes, with 32% at goal (P < 0.0001).CONCLUSIONS:This inpatient stroke alert quality improvement initiative decreased median inpatient alert‐to‐CT time by 57%, and demonstrated that speed of in‐hospital stroke evaluation can be improved through systematic application of quality improvement principles. Journal of Hospital Medicine 2012; © 2011 Society of Hospital Medicine
Exogenous and autocrine growth factors stimulate human intervertebral disc cell proliferation via the ERK and Akt pathways
Authors: Pratsinis Harris , Constantinou Vasos , Pavlakis Kitty , Sapkas George , Kletsas Dimitris 
Published: November 2011

AbstractIntervertebral disc (IVD) degeneration is accompanied by growth factor‐overexpression and increased cell proliferation, probably representing a tissue repair process. Accordingly, we studied the effect of exogenous and autocrine growth factors on the proliferation of human IVD cells. We observed that Platelet‐Derived Growth Factor (PDGF), basic Fibroblast Growth Factor (bFGF), and Insulin‐like Growth Factor‐I (IGF‐I) stimulate DNA synthesis of human IVD cells, through the activation of the MEK/ERK and the PI‐3K/Akt signal transduction pathways. Furthermore, medium conditioned (CM) by IVD cells induced DNA synthesis in the same cells, indicating the secretion of autocrine growth factors. The MEK/ERK and PI‐3K/Akt pathways were also induced by CM, while their inhibition reversed in large part the DNA synthesis induction by CM. These responses to the exogenous and autocrine growth factors were qualitatively similar in both nucleus pulposus (NP) and annulus fibrosus (AF) cell cultures. Immunohistochemical studies in human biopsies showed significant activation of both signaling pathways, which was most prominent in the clusters of proliferating cells. These in vitro and in vivo data indicate that the proliferation of human IVD cells is regulated by exogenous and autocrine growth factors mainly via the MEK/ERK and PI‐3K/Akt pathways; this may contribute to the design of future interventional approaches. © 2011 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 30:958–964, 2012
Late nitrogen fertilization affects nitrogen remobilization in wheat
Authors: Fuertes‐Mendizábal Teresa , González‐Murua Carmen , González‐Moro Ma. B. , Estavillo José M. 
Published: November 2011

AbstractA pot experiment with wheat plants was carried out to study how late application of nitrogen (N) fertilizer affects the use of pre‐anthesis N reserves during the grain‐filling period. Increasing doses of N fertilizer were applied (0, 40, and 52 mg N plant–1), either in two amendments (growth stages GS20 and GS30, according to Zadoks scale) or in three amendments (GS20, GS30, and GS37). The experiment was arranged in a complete randomized three‐block design with 129 plants per treatment. The plants were watered daily, harvested every 2 d between anthesis and maturity, and were separated into roots, leaf sheaths, leaf blades, and ears for further N determination. Grain N concentration improved due to a late N application in GS37 by 14% (higher N dose) and by 7% (further splitting the same N‐fertilizer dose, respectively). The higher the N‐fertilizer dose applied, the greater was the amount of pre‐anthesis reserves in vegetative organs, these reserves became later available for remobilization. Although splitting the same N dose in three amendments did not increase the N reserves, these reserves were more efficiently remobilized allowing an improvement in grain N concentration. The fertilizer management did not change the temporary pattern of N accumulation in the ear, but did induce a change in the amount of N remobilized and in the contribution of each organ (root, leaf sheath, leaf blade) to this remobilization. Late N amendment allowed a greater N availability of leaf blades and ear N reserves (from 20% up to 26% and from 19% up to 22%, respectively) for remobilization towards the grain, decreasing the root contribution from 28% down to 15%, while the contribution of leaf sheaths was maintained around 35% irrespective of the N applied.
Determination of phenolic compounds in environmental water samples after solid‐phase extraction with β‐cyclodextrin‐bonded silica particles coupled with a novel liquid‐phase microextraction followed by gas chromatography‐mass spectrometry
Authors: Faraji Hakim , Husain Syed W. , Helalizadeh Masoumeh 
Published: November 2011

AbstractA novel approach for the sample pre‐treatment and determination of eight phenolic compounds in environmental water samples has been developed by hyphenating solid‐phase extraction (SPE) and liquid‐phase microextraction (LPME) techniques based on solid organic drop combined with gas chromatography‐mass spectrometry detection (GC‐MS). After pre‐concentration and purification of the sample through column containing 60 mg of β‐cyclodextrin‐bonded silica particles as stationary phase, under the optimum conditions, LPME technique has been performed on the eluent solution. Under the selected conditions, limit of detection (LOD) of 0.002–0.04 μg/L (S/N=3), limit of quantification (LOQ) of 0.007–0.15 μg/L (S/N=10), pre‐concentration factor of 752–3135 and linearity range of 0.01–25 μg/L have been obtained. A reasonable repeatability (RSD≤9.5%, n=5) with satisfactory coefficient of determination has been obtained between 0.9981 and 0.9997. The relative recoveries of the waste, sea, river and well water samples were higher than 79%.
Microstrip dual‐band bandpass and bandstop filters
Authors: Vegesna Subash , Saed Mohammad 
Published: November 2011

AbstractIn this letter, simple and effective design of dual‐band bandpass and bandstop filters using microstrip open‐loop resonators is proposed.The dual‐band bandpass and bandstop filters developed in this letter exhibit dual operating frequencies that are not integral multiples of each other and are realized using a simple method rather than using the extensive method of extracting coupling coefficient matrix for designing dual‐band filters. Parametric analysis is performed on the proposed microstrip structures to determine the optimum dimensions of the dual‐band filters. Both simulation and measured results are presented in this letter, and good agreement is obtained between the results. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:168–171, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26469
New coupled‐line dual‐band dc‐block transformer for arbitrary complex frequency‐dependent load impedance
Authors: Wu Yongle , Liu Yuanan , Li Shulan , Yu Cuiping 
Published: November 2011

AbstractA novel impedance transformer is constructed by interpolating coupled line in this article. This proposed coupled‐line transformer not only has arbitrary dual‐band operation for arbitrary complex frequency‐dependent load impedance but also features inherent DC‐block function. The design of its electrical parameters can be obtained by using simple closed‐form design equations. Furthermore, the practical scope of load impedance for this transformer is analyzed, and the corresponding analytical design approach is verified by seven numerical examples. Finally, experimental results for a microstrip coupled‐line dual‐band impedance transformer with center frequencies at 1.45 and 2.61 GHz are in excellent agreement with the circuit‐based simulated results. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:139–142, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26480
Enhancing ground plane immunity of dipole antennas with spin–spray‐deposited lossy ferrite films
Authors: Yang Guo‐Min , Obi Ogheneyunume , Sun Nian X. 
Published: November 2011

AbstractThis article presented a low‐profile dipole antenna with enhanced ground immunity by using spin–spray‐deposited ferrite films. To reduce the mutual coupling between the antenna and the ground plane, Fe3O4–ferrite films were added below the dipole antenna. Novel dipole antennas with lossy Fe3O4–ferrite films loading were designed and analyzed. Under the condition of low profile of 2 mm, a good reflection coefficient of −24.6 dB was obtained when antennas were loaded with lossy ferrite films, which shows great promising for the antenna miniaturization in the modern wireless communication. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:230–233, 2012.
Strain and satisfaction in caregivers of veterans with chronic illness
Authors: Wakefield Bonnie J. , Hayes Jeanne , Boren Suzanne Austin , Pak Youngju , Davis J. Wade 
Published: November 2011

AbstractVeterans' health care has shifted towards outpatient treatment, and because of the high prevalence of chronic illness in veterans, more caregiving has been required of their families. The purpose of this study was to identify predictors of caregiver (CG) strain and satisfaction associated with caring for veterans with chronic illness. Data were collected using telephone interviews of 120 dyads. Strain was associated with helping with instrumental activities of daily living, using counseling and prayer for coping, accompanying veteran to appointments, help/advice from friends, paid help, exercising, and depression. Satisfaction was associated with veteran health, CG social support, age, and depression. Innovative and easily accessible interventions are needed to mitigate sources of strain in CGs of chronically ill veterans. Published 2011. This article is a U.S. Government work and is in the public domain in the USA. Res Nurs Health
35:55‐69, 2012
Dental Anomalies in the Mandible of Capra pyrenaica: Presence of Two Permanent Fourth Premolars in a Pleistocene Wild Goat from Arlanpe Cave (Bizkaia, Northern Spain)
Authors: Gómez‐Olivencia Asier , Arceredillo Diego , Rios‐Garaizar Joseba , Garate Diego , Iriarte Eneko , Pedro Ziortza San 
Published: November 2011

ABSTRACTIn this study, we report a case of duplication of a lower fourth premolar (P4) on an Iberian wild goat from the archaeological site cave of Arlanpe, (Lemoa, Bizkaia, Northern Spain). The preserved right mandible corpus displays two premolars and the first molar (M1). Both premolars conform in size and general shape to fourth premolars (P4) but the medialmost of the two is rotated 90° counterclockwise, and thus, its wear pattern is different. The comparative analysis to other bovids and the relative scarcity of this anomaly compared to other cases of polydontia and hypodontia suggest that it is a developmental defect consisting in the duplication of the tooth germ, and we doubt on the potential of this abnormality as a territorially based indicator of past wild populations as has been previously proposed. Copyright © 2011 John Wiley & Sons, Ltd.
Low‐grade serous carcinomas of the ovary contain very few point mutations
Authors: Jones Siân , Wang Tian‐Li , Kurman Robert J , Nakayama Kentaro , Velculescu Victor E , Vogelstein Bert , Kinzler Kenneth W , Papadopoulos Nickolas , Shih Ie‐Ming 
Published: November 2011

AbstractIt has been well established that ovarian low‐grade and high‐grade serous carcinomas are fundamentally different types of tumours. While the molecular genetic features of ovarian high‐grade serous carcinomas are now well known, the pathogenesis of low‐grade serous carcinomas, apart from the recognition of frequent somatic mutations involving KRAS and BRAF, is largely unknown. In order to comprehensively analyse somatic mutations in low‐grade serous carcinomas, we applied exome sequencing to the DNA of eight samples of affinity‐purified, low‐grade, serous carcinomas. A remarkably small number of mutations were identified in seven of these tumours: a total of 70 somatic mutations in 64 genes. The eighth case displayed mixed serous and endometrioid features and a mutator phenotype with 783 somatic mutations, including a nonsense mutation in the mismatch repair gene, MSH2. We validated representative mutations in an additional nine low‐grade serous carcinomas and 10 serous borderline tumours, the precursors of ovarian low‐grade, serous carcinomas. Overall, the genes showing the most frequent mutations were BRAF and KRAS, occurring in 10 (38%) and 5 (19%) of 27 low‐grade tumours, respectively. Except for a single case with a PIK3CA mutation, other mutations identified in the discovery set were not detected in the validation set of specimens. Our mutational analysis demonstrates that point mutations are much less common in low‐grade serous tumours of the ovary than in other adult tumours, a finding with interesting scientific and clinical implications. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Ferromagnetism in rare earth doped cerium oxide bulk samples
Authors: Dimri M. Chandra , Khanduri H. , Kooskora H. , Subbi J. , Heinmaa I. , Mere A. , Krustok J. , Stern R. 
Published: November 2011

AbstractMagnetic properties of rare earth (RE) doped ceria (RE = Nd, Sm, Gd, Tb, Er and Dy) samples have been investigated and reported in this paper. Room temperature ferromagnetism (FM) was observed in calcined powders as well as in sintered samples of Nd and Sm doped CeO2, whereas other RE dopants (Gd, Tb, Er and Dy) in CeO2 exhibit paramagnetic behaviour. The origin of magnetism in these samples can be related to oxygen vacancies and formation of fluorite crystal structure. Though the magnetization was found to be lower as compared to transition metal (TM) doped ceria, the segregation of metallic and secondary phases can be avoided in RE doped CeO2. CeO2 doped with Sm ions in different concentration (1, 5 and 15%) were also studied to see the dopant effects on magnetic properties. The origin of magnetism in these samples may be related to the oxygen vacancies created due to RE dopants, which was confirmed from the peak around 555 cm−1 in Raman spectra.
Morphology evolution and optical properties of GaN nano‐pyramids grown by selective area MOVPE
Authors: Winden Andreas , Mikulics Martin , Haab Anna , Stoica Toma , von der Ahe Martina , Wirtz Konrad , Hardtdegen Hilde , Grützmacher Detlev 
Published: November 2011

AbstractThe evolution of GaN nano‐pyramid growth by selective area metalorganic vapor phase epitaxy (SA‐MOVPE) on GaN/c‐plane sapphire templates with extremely low pattern fill factor and large inter‐hole spacing was studied with scanning electron microscopy (SEM). The optical nanostructure characteristics were investigated by micro‐photoluminescence spectroscopy at room temperature. It was found that sub‐100 nm structures can be fabricated by controlling the growth time and mask opening size. Single nanostructures exhibit more intense luminescence and a red shift of the band edge transition compared to the GaN layer. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Flexible Field Emission from Thermally Welded Chemically Doped Graphene Thin Films
Authors: Jeong Hee Jin , Jeong Hae Deuk , Kim Ho Young , Kim Sung Hun , Kim Jun Suk , Jeong Seung Yol , Han Joong Tark , Lee Geon‐Woong 
Published: November 2011

AbstractFlexible field‐emission devices (FEDs) based on reduced graphene oxide (RGO) emitters are fabricated by the thermal welding of RGO thin films onto a polymeric substrate. The RGO edges are vertically aligned relative to the substrate as a result of cohesive failure in the RGO layer after thermal welding. Even at large bending angles, excellent electron emission properties, such as low turn‐on and threshold fields, a high emission current density, a high field enhancement factor, and long‐term stability of the emission properties of RGO emitters, arise from the uniform distribution and high density of the extremely sharp RGO edges, as well as the high interfacial strength between the RGO emitters and the substrate. Al‐ and Au‐doped RGO emitters are fabricated by introducing a dopant solution to the RGO emitters, and the resulting field‐emission characteristics are discussed. The proposed approach is straightforward and enables the practical use of high‐performance RGO flexible FEDs.
Recent trends in conformational analysis
Authors: Mazzanti Andrea , Casarini Daniele 
Published: November 2011

AbstractAn outlook of the various research fields of organic chemistry where conformational analysis plays a fundamental role is presented. The section Methodologies for Conformational Analysis is focused on the information that can be obtained by various spectroscopic techniques such as nuclear magnetic resonance and optical methods such as electronic circular dichroism and vibrational circular dichroism. A comprehensive screening of the more recent ab initio and density functional theory theoretical approaches to conformational analysis is presented in the section Theoretical Conformational Analysis. The section Application of Conformational Analysis to the Determination of the AC of Organic Molecules shows how the synergic use of experimental and theoretical methods can solve challenging conformational tasks arising from modern organic chemistry. © 2011 John Wiley & Sons, Ltd.This article is categorized under:

Electronic Structure Theory > Density Functional Theory
Multiconfiguration second‐order perturbation theory approach to strong electron correlation in chemistry and photochemistry
Authors: Roca‐Sanjuán Daniel , Aquilante Francesco , Lindh Roland 
Published: November 2011

AbstractRooted in the very fundamental aspects of many chemical phenomena, and for the majority of photochemistry, is the onset of strongly interacting electronic configurations. To describe this challenging regime of strong electron correlation, an extraordinary effort has been put forward by a young generation of scientists in the development of theories ‘beyond’ standard wave function and density functional models. Despite their encouraging results, a twenty‐and‐more‐year old approach still stands as the gold standard for these problems: multiconfiguration second‐order perturbation theory based on complete active space reference wave function (CASSCF/CASPT2). We will present here a brief overview of the CASSCF/CASPT2 computational protocol, and of its role in our understanding of chemical and photochemical processes. © 2011 John Wiley & Sons, Ltd.This article is categorized under:

Electronic Structure Theory > Ab Initio Electronic Structure Methods
Grassland bird nest ecology and survival in upland habitat buffers near wooded edges
Authors: Conover Ross R. , Burger L. Wes , Linder Eric T. 
Published: November 2011

AbstractUpland habitat buffers (i.e., strips of noncrop, herbaceous vegetation) that are established adjacent to wooded fencerows offer landowners an economical option to provide wildlife benefits within intensive agricultural landscapes. However, being located near a wooded edge may increase grassland bird vulnerability to edge effects through reduced nest survival. We examined nesting bird communities in field margins adjacent to wooded field edges with no buffer (i.e., control), narrow (approx. 10‐m) buffers, and wide (approx. 30‐m) buffers in an intensive agricultural system in the Lower Mississippi Alluvial Valley, United States. Dickcissel (Spiza americana) and red‐winged blackbird (Agelaius phoeniceus) accounted for 97% of nests. Nest density was >7 times greater in wide buffers than in narrow. We modeled nest survival in Program MARK as a function of time (yr and season), nest‐site, and local vegetation characteristics. Nest survival was influenced by among‐ and within‐season temporal effects and local vegetation structure, but not by buffer width. Nest success varied substantially between years and within seasons for dickcissel (12.9% and 19.1% early in the seasons of 2003 and 2004, respectively), but not for red‐winged blackbird (15.1%). Overall nest‐success estimates were similar to noncrop, herbaceous strips elsewhere in the United States, though whether or not these estimates represent population sinks remains uncertain. Based on this research, we advocate integrating upland habitat buffers within intensive agricultural landscapes and emphasize the use of wide buffers when grassland‐nesting birds are a conservation priority. © 2011 The Wildlife Society.
Update and new concepts in vitamin responsive disorders of folate transport and metabolism
Authors: Watkins David , Rosenblatt David S. 
Published: November 2011

AbstractDerivatives of folic acid are involved in transfer of one‐carbon units in cellular metabolism, playing a role in synthesis of purines and thymidylate and in the remethylation of homocysteine to form methionine. Five inborn errors affecting folate transport and metabolism have been well studied: hereditary folate malabsorption, caused by mutations in the gene encoding the proton‐coupled folate transporter (SLC46A1); glutamate formiminotransferase deficiency, caused by mutations in the FTCD gene; methylenetetrahydrofolate reductase deficiency, caused by mutations in the MTHFR gene; and functional methionine synthase deficiency, either as the result of mutations affecting methionine synthase itself (cblG, caused by mutations in the MTR gene) or affecting the accessory protein methionine synthase reductase (cblE, caused by mutations in the MTRR gene). Recently additional inborn errors have been identified. Cerebral folate deficiency is a clinically heterogeneous disorder, which in a few families is caused by mutations in the FOLR1 gene. Dihydrofolate reductase deficiency is characterized by megaloblastic anemia and cerebral folate deficiency, with variable neurological findings. It is caused by mutations in the DHFR gene. Deficiency in the trifunctional enzyme containing methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrolase and formyltetrahydrofolate synthetase activities, has been identified in a single patient with megaloblastic anemia, atypical hemolytic uremic syndrome and severe combined immune deficiency. It is caused by mutations in the MTHFD1 gene.