bluuebunny/crossref_metadata_2025_split huggingface dataset:
>“Virtue Makes the Goal Right”: Virtue and Phronesis in Aristotle’s Ethics
Authors: Moss Jessica 
Published: July 2011

AbstractAristotle repeatedly claims that character-virtue “makes the goal right”, while Phronesis is responsible for working out how to achieve the goal. Many argue that these claims are misleading: it must be intellect that tells us what ends to pursue. I argue that Aristotle means just what he seems to say: despite putative textual evidence to the contrary, virtue is (a) a wholly non-intellectual state, and (b) responsible for literally supplying the contents of our goals. Furthermore, there are no good textual or philosophical reasons to reject this straightforward interpretation. Contrary to widespread opinion, Aristotle does not characterize Phronesis as supplying ends. Instead, its ethical import lies wholly in its ability to “determine the mean”. Moreover, because character involves non-rational cognition of the end as good, Aristotle can restrict practical intellect to deliberation without abandoning his anti-Humean view that we desire our ends because we find them good.
Saviour-Sibling and the Psychological, Ethical and Judicial Issues that It Creates: Should English and French Legislators Close the Pandora’s Box?
Authors: Madanamoothoo Allane 
Published: July 2011

AbstractSince the advent of test-tube babies, advances in the biomedical field have risen steadily. In parallel, the scientific body has never since ceased to debate the ethical issues that they arise. This is particularly the case regarding saviour-sibling. Saviour-sibling refers to a child who is conceived to cure an older brother or sister suffering from a serious family genetic disease. Therefore, it is meant to give birth to a child who will provide stem-cells taken from the umbilical cord or bone marrow afterwards, to treat an elder sick sibling. In England, this practice has been explicitly allowed by the new Human Fertilisation and Embryology Act 2008 under some strict conditions. In France, this practice, authorized by the Bioethics Law of August 2004 and confirmed by its decree of implementation published in the Official Journal on 23 December 2006, is also strictly regulated. This technique opens up new perspectives and enormous hope. Its legalisation is certainly justified by the suffering of the parents and to avoid that they travel to other States where it is permitted. However, it raises serious psychological ethical and judicial issues. Following an analysis of the English and French laws on saviour siblings, its controversial side will be highlighted, before concluding whether or not this new Pandora’s box which is saviour-sibling, should be closed and other alternative methods encouraged.
Printing the Samgang haengsil-to (Illustrated Guide to the Three Relationships), a Premodern Korean Moral Primer*
Authors: Kyun Oh Young 
Published: July 2011

AbstractThe Samgang haengsil-to is a collection of Chinese and Korean stories of exemplary conduct performed by filial sons, loyal subjects and devoted women, which epitomize Confucian virtue entailed in the three fundamental human relations. These stories were first written in classical Chinese, accompanied by illustrations, and later appeared with vernacular Korean texts added. Ever since it was published by the court in 1434, the Samgang haengsil-to underwent numerous editorial changes during the first half of Chosn dynasty (1392-1910) with respect to the selection of stories, the content, the language, and even the appearance of the book. These changes were not made at random, nor are they addressing mere practical reasons such as facilitating reading or enhancing the book’s aesthetic appeal. Rather, there was a certain political and cultural context at work behind these changes, which reflected the shifting value system and the process of Confucianization of Chosn Korea. By tracing the major changes made to different editions of the Samgang haengsil-to, this paper discusses the influences that social and political environments exert on a text.
UK student alcohol consumption: A cluster analysis of drinking behaviour typologies
Authors: Craigs Cheryl L , Bewick Bridgette M , Gill Jan , O’May Fiona , Radley Duncan 
Published: July 2011

Objective: To assess the extent to which university students are following UK Government advice regarding appropriate consumption of alcohol, and to investigate if students can be placed into distinct clusters based on their drinking behaviour. Design: A descriptive questionnaire study. Setting: One hundred and nineteen undergraduate students from Leeds Metropolitan University, UK. Method: An online survey, which included a diary to record daily alcohol consumption over the previous week, was completed during the winter of 2007/08. Cluster analysis was used to classify students into subgroups based on comparable alcohol-drinking characteristics. National recommended sensible drinking behaviour guidelines in terms of total weekly alcohol intake, maximum daily alcohol intake, number of alcohol-free days and estimated blood alcohol levels were used to compare drinking behaviour the previous week by age, sex and cluster group. Results: Consuming weekly alcohol levels considered hazardous was common (58%) with nearly 70% of responders binge drinking at least once over that period; most students (80%) were, however, following the government’s recommendation for two consecutive alcohol-free days per week. No significant differences in drinking behaviour by sex were found, but binge drinkers tended to be younger. Four distinct alcohol-drinking behaviour clusters were identified based on alcohol consumption frequency and quantity. Only students in the non or light drinkers group all remained within national recommended guidelines for weekly intake and alcohol-free days. Conclusion: Students who consume alcohol are commonly drinking daily and weekly alcohol levels in excess of national sensible drinking guidelines; most students, however, abstain from alcohol on at least two consecutive days. The four distinct drinking clusters suggest that students would benefit from targeted interventions. In particular, personalization of interventions to reflect the distinct patterns of drinking behaviour could increase intervention effectiveness.
Factors associated with frequent psychiatric admissions in a general hospital in Spain
Authors: Martínez-Ortega José M. , Gutiérrez-Rojas Luis , Jurado Dolores , Higueras Antonio , Diaz Francisco J. , Gurpegui Manuel 
Published: July 2011

Objectives: To identify demographic or clinical factors associated with frequent admissions in a sample of patients admitted to an acute psychiatric hospitalization unit, controlling for potentially confounding factors. Methods: Socio-demographic variables, diagnosis, and the legal status, date and length of admission were collected for 1,722 consecutively admitted psychiatric patients during a period of up to eight years (1998–2005). Frequently admitted patients were defined as undergoing one or more admissions per year on average. Results: After controlling for potential confounding factors, logistic regression showed that being a frequently admitted patient was significantly associated with diagnoses of schizoaffective disorder, personality disorder or schizophrenia; an involuntary commitment at first admission; and younger age. Conclusions: Factors associated with frequently admitted patients should be identified in order to establish more effective strategies for preventing relapse.
Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemia
Authors: Bluteau Dominique , Gilles Laure , Hilpert Morgane , Antony-Debré Iléana , James Chloe , Debili Najet , Camara-Clayette Valerie , Wagner-Ballon Orianne , Cordette-Lagarde Veronique , Robert Thomas , Ripoche Hugues , Gonin Patrick , Swierczek Sabina , Prchal Josef , Vainchenker William , Favier Remi , Raslova Hana 
Published: July 2011

Abstract
RUNX1 encodes a DNA-binding α subunit of the core-binding factor, a heterodimeric transcription factor. RUNX1 is a master regulatory gene in hematopoiesis and its disruption is one of the most common aberrations in acute leukemia. Inactivating or dominant-negative mutations in the RUNX1 gene have been also identified in pedigrees of familial platelet disorders with a variable propensity to develop acute myeloid leukemia (FPD/AML). We performed analysis of hematopoiesis from 2 FPD/AML pedigrees with 2 distinct RUNX1 germline mutations, that is, the R139X in a pedigree without AML and the R174Q mutation in a pedigree with AML. Both mutations induced a marked increase in the clonogenic potential of immature CD34+CD38− progenitors, with some self-renewal capacities observed only for R174Q mutation. This increased proliferation correlated with reduction in the expression of NR4A3, a gene previously implicated in leukemia development. We demonstrated that NR4A3 was a direct target of RUNX1 and that restoration of NR4A3 expression partially reduced the clonogenic potential of patient progenitors. We propose that the down-regulation of NR4A3 in RUNX1-mutated hematopoietic progenitors leads to an increase in the pool of cells susceptible to be hit by secondary leukemic genetic events.
Lenalidomide as initial therapy of elderly patients with chronic lymphocytic leukemia
Authors: Badoux Xavier C. , Keating Michael J. , Wen Sijin , Lee Bang-Ning , Sivina Mariela , Reuben James , Wierda William G. , O'Brien Susan M. , Faderl Stefan , Kornblau Steven M. , Burger Jan A. , Ferrajoli Alessandra 
Published: July 2011

AbstractThe best initial therapy for elderly patients with chronic lymphocytic leukemia (CLL) has not yet been defined. We investigated the activity of lenalidomide as initial therapy for elderly patients with CLL. Sixty patients with CLL 65 years of age and older received treatment with lenalidomide orally 5 mg daily for 56 days, then titrated up to 25 mg/d as tolerated. Treatment was continued until disease progression. At a median follow-up of 29 months, 53 patients (88%) are alive and 32 patients (53%) remain on therapy. Estimated 2-year progression-free survival is 60%. The overall response rate to lenalidomide therapy is 65%, including 10% complete response, 5% complete response with residual cytopenia, 7% nodular partial response, and 43% partial response. Neutropenia is the most common grade 3 or 4 treatment-related toxicity observed in 34% of treatment cycles. Major infections or neutropenic fever occurred in 13% of patients. Compared with baseline levels, we noted an increase in serum immunoglobulin levels across all classes, and a reduction in CCL3 and CCL4 plasma levels was noted in responding patients. Lenalidomide therapy was well tolerated and induced durable remissions in this population of elderly, symptomatic patients with CLL. This study was registered at www.clinicaltrials.gov as #NCT00535873.
Construction of a computable cell proliferation network focused on non-diseased lung cells
Authors: Westra Jurjen W , Schlage Walter K , Frushour Brian P , Gebel Stephan , Catlett Natalie L , Han Wanjiang , Eddy Sean F , Hengstermann Arnd , Matthews Andrea L , Mathis Carole , Lichtner Rosemarie B , Poussin Carine , Talikka Marja , Veljkovic Emilija , Van Hooser Aaron A , Wong Benjamin , Maria Michael J , Peitsch Manuel C , Deehan Renee , Hoeng Julia 
Published: July 2011

Abstract

Background
Critical to advancing the systems-level evaluation of complex biological processes is the development of comprehensive networks and computational methods to apply to the analysis of systems biology data (transcriptomics, proteomics/phosphoproteomics, metabolomics, etc.). Ideally, these networks will be specifically designed to capture the normal, non-diseased biology of the tissue or cell types under investigation, and can be used with experimentally generated systems biology data to assess the biological impact of perturbations like xenobiotics and other cellular stresses. Lung cell proliferation is a key biological process to capture in such a network model, given the pivotal role that proliferation plays in lung diseases including cancer, chronic obstructive pulmonary disease (COPD), and fibrosis. Unfortunately, no such network has been available prior to this work.

Results
To further a systems-level assessment of the biological impact of perturbations on non-diseased mammalian lung cells, we constructed a lung-focused network for cell proliferation. The network encompasses diverse biological areas that lead to the regulation of normal lung cell proliferation (Cell Cycle, Growth Factors, Cell Interaction, Intra- and Extracellular Signaling, and Epigenetics), and contains a total of 848 nodes (biological entities) and 1597 edges (relationships between biological entities). The network was verified using four published gene expression profiling data sets associated with measured cell proliferation endpoints in lung and lung-related cell types. Predicted changes in the activity of core machinery involved in cell cycle regulation (RB1, CDKN1A, and MYC/MYCN) are statistically supported across multiple data sets, underscoring the general applicability of this approach for a network-wide biological impact assessment using systems biology data.

Conclusions
To the best of our knowledge, this lung-focused Cell Proliferation Network provides the most comprehensive connectivity map in existence of the molecular mechanisms regulating cell proliferation in the lung. The network is based on fully referenced causal relationships obtained from extensive evaluation of the literature. The computable structure of the network enables its application to the qualitative and quantitative evaluation of cell proliferation using systems biology data sets. The network is available for public use.
A simple and efficient tool for trapping gravid Anopheles at breeding sites
Authors: Harris Caroline , Kihonda Japhet , Lwetoijera Dickson , Dongus Stefan , Devine Gregor , Majambere Silas 
Published: July 2011

Abstract

Background
No effective tool currently exists for trapping ovipositing malaria vectors. This creates a gap in our ability to investigate the behavior and ecology of gravid Anopheles.

Findings
Here we describe a simple trap that collects ovipositing Anopheline and Culicine mosquitoes. It consists of an acetate sheet coated in glue that floats on the water surface. Ten breeding sites were selected in rural Tanzania and 10 sticky traps set in each. These caught a total of 74 gravid Anopheles (54 An. arabiensis, 1 An. gambiae s.s. and 16 unamplified) and 1333 gravid Culicines, in just two trap nights. This simple sampling tool provides an opportunity to further our understanding of the behavior and ecology of gravid female Anophelines. It strongly implies that at least two of the major vectors of malaria in Africa land on the water surface during the oviposition process, and demonstrates that Anophelines and Culicines often share the same breeding sites.

Conclusion
This simple and efficient trap has clear potential for the study of oviposition site choice and productivity, gravid dispersal, and vector control techniques which use oviposition behavior as a means of disseminating larvicides.
Development of tolerogenic dendritic cells and regulatory T cells favors exponential bacterial growth and survival during early respiratory tularemia
Authors: Periasamy Sivakumar , Singh Anju , Sahay Bikash , Rahman Tabassum , Feustel Paul J , Pham Giang H , Gosselin Edmund J , Sellati Timothy J 
Published: July 2011

ABSTRACTTularemia is a vector-borne zoonosis caused by Ft, a Gram-negative, facultative intracellular bacterium. Ft exists in two clinically relevant forms, the European biovar B (holarctica), which produces acute, although mild, self-limiting infections, and the more virulent United States biovar A (tularensis), which is often associated with pneumonic tularemia and more severe disease. In a mouse model of tularemia, respiratory infection with the virulence-attenuated Type B (LVS) or highly virulent Type A (SchuS4) strain engenders peribronchiolar and perivascular inflammation. Paradoxically, despite an intense neutrophilic infiltrate and high bacterial burden, Th1-type proinflammatory cytokines (e.g., TNF, IL-1β, IL-6, and IL-12) are absent within the first ∼72 h of pulmonary infection. It has been suggested that the bacterium has the capacity to actively suppress or block NF-κB signaling, thus causing an initial delay in up-regulation of inflammatory mediators. However, our previously published findings and those presented herein contradict this paradigm and instead, strongly support an alternative hypothesis. Rather than blocking NF-κB, Ft actually triggers TLR2-dependent NF-κB signaling, resulting in the development and activation of tDCs and the release of anti-inflammatory cytokines (e.g., IL-10 and TGF-β). In turn, these cytokines stimulate development and proliferation of Tregs that may restrain Th1-type proinflammatory cytokine release early during tularemic infection. The highly regulated and overall anti-inflammatory milieu established in the lung is permissive for unfettered growth and survival of Ft. The capacity of Ft to evoke such a response represents an important immune-evasive strategy.
Direct Decomposition of NO into N2 and O2 on C-type Cubic Y2O3–ZrO2 and Y2O3–ZrO2–BaO
Authors: Tsujimoto Soichiro , Wang Xiaojing , Masui Toshiyuki , Imanaka Nobuhito 
Published: July 2011

Abstract
Catalytic activities for direct NO decomposition were investigated on C-type cubic Y2O3–ZrO2 and Y2O3–ZrO2–BaO prepared by coprecipitation. Introduction of excess oxide anions in the Y2O3 lattice was achieved by partial substitution of the Y3+ sites with Zr4+, and high NO decomposition activity was obtained for the (Y0.97Zr0.03)2O3.03 catalyst. In addition, the catalytic activity was further enhanced by partial substitution of the Y3+ sites in the Y2O3–ZrO2 solid solution with Ba2+, and the (Y0.89Zr0.07Ba0.04)2O3.03 catalyst exhibited the highest NO decomposition activity among the samples prepared; NO conversion to N2 reached 90% at 1173 K in the absence of O2 (NO/He atmosphere), and a relatively high conversion ratio was observed even in the presence of O2, H2O, or CO2, compared with the activities of conventional direct NO decomposition catalysts. These results indicate that the C-type cubic Y2O3–ZrO2–BaO catalyst is a new potential candidate for direct NO decomposition.
Compensated pathogenic deviations
Authors: Barešić Anja , Martin Andrew C.R. 
Published: July 2011

AbstractDeleterious or ‘disease-associated’ mutations are mutations that lead to disease with high phenotype penetrance: they are inherited in a simple Mendelian manner, or, in the case of cancer, accumulate in somatic cells leading directly to disease. However, in some cases, the amino acid that is substituted resulting in disease is the wild-type native residue in the functionally equivalent protein in another species. Such examples are known as ‘compensated pathogenic deviations’ (CPDs) because, somewhere in the second species, there must be compensatory mutations that allow the protein to function normally despite having a residue which would cause disease in the first species. Depending on the nature of the mutations, compensation can occur in the same protein, or in a different protein with which it interacts. In principle, compensation can be achieved by a single mutation (most probably structurally close to the CPD), or by the cumulative effect of several mutations. Although it is clear that these effects occur in proteins, compensatory mutations are also important in RNA potentially having an impact on disease. As a much simpler molecule, RNA provides an interesting model for understanding mechanisms of compensatory effects, both by looking at naturally occurring RNA molecules and as a means of computational simulation. This review surveys the rather limited literature that has explored these effects. Understanding the nature of CPDs is important in understanding traversal along fitness landscape valleys in evolution. It could also have applications in treating diseases that result from such mutations.
Educational Possibilities of the Project Colour Visualization of Music
Authors: Klemenc Bojan , Ciuha Peter , Solina Franc 
Published: July 2011

Educational Possibilities of the Project Colour Visualization of Music
We propose a system of colour visualization of music based on a system of colour signs, which are connected to musical tones. Tones, which are in harmonic relationships, are represented by related colours. First, we outline the foundations on which the system of colour signs is based - the mathematical model of harmony. We discuss several possibilities of visual representation of expressive elements of music - melody, composition, rhythm and harmony. These relationships enabled us to develop a computer program that employs these elements for visualization. The program mimics human perception in which the parts are determined by the perception of the whole. Furthermore, the program enables the development of tools that can enhance music understanding during listening or performing. Music performance can acquire a new quality with the use of interactive coloured musical instruments, which by using colours show the performer different possibilities for forming musical harmonies and thereby change the composing of music into a game and attractive colour-aural journey. Here we stumble upon a challenge for educational science and methodology: how to use such upcoming multimedia tools. These tools would bring the processes of learning and playing a game closer together since playing games is a child's most natural form of functioning. Furthermore, in the area of artistic creation we can once again establish a balance between our logical and intuitive nature.
Measurement of Three-Dimensional Magnetostriction on Grain-Oriented Electrical Steel Sheet
Authors: Wakabayashi Daisuke , Todaka Takashi , Enokizono Masato 
Published: July 2011

Measurement of Three-Dimensional Magnetostriction on Grain-Oriented Electrical Steel Sheet
This paper deals with the magnetostriction of a grain-oriented electrical steel sheet measured by using the two-dimensional vector magnetic property measurement system and a three-axial strain gage. The magnetostrictions in arbitrary direction are calculated with the measured strain tensors. The magnetostriction characteristics were changed depending on the magnetization process according to the exciting magnetic flux density and the exciting direction. In this paper, we make clear the relationship among the two-dimensional magnetostriction, the magnetic flux density vector, and the magnetic field intensity vector in the grain-oriented electrical steel sheet.