bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase 2 trial of talampanel, a glutamate receptor inhibitor, for adults with recurrent malignant gliomas
Authors: Iwamoto Fabio M. , Kreisl Teri N. , Kim Lyndon , Duic J. Paul , Butman John A. , Albert Paul S. , Fine Howard A. 
Published: February 2010

AbstractBACKGROUND:Glioma cells secrete glutamate and also express α‐amino‐3‐hydroxy‐5 methyl‐4‐isoxazolepropionate (AMPA) glutamate receptors, which contribute to the proliferation, migration, and neurotoxicity of malignant gliomas. Talampanel is an oral AMPA receptor inhibitor with excellent central nervous system penetration and good tolerability in clinical trials for epilepsy and other neurologic disorders.METHODS:A phase 2 trial was conducted to evaluate the efficacy of talampanel in patients with recurrent malignant glioma as measured by 6‐month progression‐free survival (PFS6).RESULTS:Thirty patients (22 with glioblastomas [GBMs] and 8 with anaplastic gliomas [AGs]; 63% men) with median age of 51 years (range, 20‐67 years) and a median Karnofsky performance scale of 80 were included. Patients tolerated treatment well, and most adverse events were mild and reversible; the most common toxicities were fatigue (27%), dizziness (23%), and ataxia (17%). There was only 1 partial response (5%) reported in the GBM stratum and none among AG patients. At a median follow‐up of 13 months, 28 patients (93%) had died. The PFS6 was 4.6% for the initial 22 GBM patients, and the study was terminated early due to treatment futility; the PFS6 was 0% for 8 AG patients. The median PFS was 5.9 weeks for GBM and 8.9 weeks for AG patients. The median overall survival was 13 weeks for GBM patients and 14 months for AG patients.CONCLUSIONS:Talampanel was well‒tolerated but had no significant activity as a single agent in unselected recurrent malignant gliomas. Cancer 2010. Published 2010 by the American Cancer Society.
Session integration service over multiple devices
Authors: Chen Min‐Xiou , Wang Fu‐Ju 
Published: February 2010

AbstractOne of the most important research subjects in session initiation protocol (SIP) is mobility management. Session mobility is a key issue in SIP mobility management. Session mobility is an advanced feature that maintains an ongoing media session from one device to another. In this paper, we consider the issue of session mobility and propose a complete integrated solution, referred to as ‘session integration service’, to transfer an ongoing media session over multiple devices. To provide flexibility in session mobility, three new agent states are introduced based on the user agent definition. They consist of session manager, session user, and free node. This paper also proposes two split session integration methods for session integration service based on these three agents. The proposed method provides session mobility flexibility and allows the user the ability to transfer, split, and retrieve a session over multiple devices. Moreover, the split session can be integrated in any devices. To ensure session mobility over multiple devices, the session integration service will be implemented through a modification of the open source project ‘SIP‐communicator’. Copyright © 2010 John Wiley & Sons, Ltd.
Polyploidy‐associated genomic instability in Arabidopsis thaliana
Authors: Wang Yixing , Jha Ajay K. , Chen Rujin , Doonan John H. , Yang Ming 
Published: February 2010

AbstractFormation of polyploid organisms by fertilization of unreduced gametes in meiotic mutants is believed to be a common phenomenon in species evolution. However, not well understood is how species in nature generally exist as haploid and diploid organisms in a long evolutionary time while polyploidization must have repeatedly occurred via meiotic mutations. Here, we show that the ploidy increased for two consecutive generations due to unreduced but viable gametes in the Arabidopsis cyclin a1;2‐2 (also named tardy asynchronous meiosis‐2) mutant, but the resultant octaploid plants produced progeny of either the same or reduced ploidy via genomic reductions during meiosis and pollen mitosis. Ploidy reductions through sexual reproduction were also observed in independently generated artificial octaploid and hexaploid Arabidopsis plants. These results demonstrate that octaploid is likely the maximal ploidy produced through sexual reproduction in Arabidopsis. The polyploidy‐associated genomic instability may be a general phenomenon that constrains ploidy levels in species evolution. genesis 48:254–263, 2010. © 2010 Wiley‐Liss, Inc.
Life beyond the eating disorder: Education, relationships, and reproduction
Authors: Maxwell Millie , Thornton Laura M. , Root Tammy L. , Pinheiro Andrea Poyastro , Strober Michael , Brandt Harry , Crawford Steve , Crow Scott , Fichter Manfred M. , Halmi Katherine A. , Johnson Craig , Kaplan Allan S. , Keel Pamela , Klump Kelly L. , LaVia Maria , Mitchell James E. , Plotnicov Kathy , Rotondo Alessandro , Woodside D. Blake , Berrettini Wade H. , Kaye Walter H. , Bulik Cynthia M. 
Published: February 2010

AbstractObjective:We investigated the sociodemographic characteristics in women with and without lifetime eating disorders.Method:Participants were from a multisite international study of eating disorders (N = 2,096). Education level, relationship status, and reproductive status were examined across eating disorder subtypes and compared with a healthy control group.Results:Overall, women with eating disorders were less educated than controls, and duration of illness and age of onset were associated with educational attainment. Menstrual status was associated with both relationship and reproductive status, but eating disorder subtypes did not differ significantly from each other or from healthy controls on these dimensions.Discussion:Differences in educational attainment, relationships, and reproduction do exist in individuals with eating disorders and are differentially associated with various eating disorder symptoms and characteristics. These data could assist in educating patients and family members about long‐term consequences of eating disorders. © 2010 by Wiley Periodicals, Inc. (Int J Eat Disord 2011; 44:225–232)
Novel RuII Complexes with Bispidine‐Based Bridging Ligands: Luminescence Sensing and Photocatalytic Properties
Authors: Busche Christoph , Comba Peter , Mayboroda Andrey , Wadepohl Hubert 
Published: February 2010

AbstractNew ligands with a bidentate bipyridyl (bpy) and a tetradentate bispidine (bisp) subunit (bipyridyl = 2,2′‐bipyridine derivative, bispidine = 3,7‐diazabicyclo[3.3.1]nonane derivative) and their heterodinuclear {[Ru(bpy)3]2+‐[M(bisp)]2+} complexes (M = Cu2+, Fe2+) were prepared and characterized. The luminescence of the mononuclear RuII complexes (metal‐free bisp subunit) is efficiently quenched in presence of CuII. An EPR spectroscopic study reveals thatvisible light irradiation does not alter the oxidation states of the two metal ions in {[Ru(bpy)3]2+‐[Cu(bisp)]2+}, i.e. there is energy rather than electron transfer. The heterodinuclear {[Ru(bpy)3]2+‐[Cu(bisp)]2+} complex shows a significantphotocatalytic activity in the aziridination of styrene.
Double‐Shelled Mn2O3 Hollow Spheres and Their Application in Water Treatment
Authors: Cao Jie , Zhu Yongchun , Shi Liang , Zhu Lingling , Bao Keyan , Liu Shuzhen , Qian Yitai 
Published: February 2010

AbstractDouble‐shelled Mn2O3 hollow spheres have been successfully prepared on a large scale by using core‐shell‐structured MnCO3 microspheres as sacrificial templates. This new method is based on an inward oxidation/etching treatment and sequential heat treatment in air. The as‐prepared double‐shelled Mn2O3 hollow spheres consist of small nanoparticles with a size of ca. 50 nm, and there are many nanopores among the particles. As the double‐shelled Mn2O3 hollow spheres were employed in water treatment, they could remove about 86 % of phenol without any other additives.
Biaryl Peptides from 4‐Iodophenylalanine by Solid‐Phase Borylation and Suzuki–Miyaura Cross‐Coupling
Authors: Afonso Ana , Rosés Cristina , Planas Marta , Feliu Lidia 
Published: February 2010

AbstractResin‐bound phenylalanine boronates were prepared by solid‐phase Miyaura borylation of 4‐iodophenylalanine peptides. Subsequent arylation through a Suzuki–Miyaura cross‐coupling was carried out using a variety of aryl halides under conventional heating and under microwave irradiation. Microwaves greatly enhanced the arylation, shortening thereaction time and providing the biaryl peptides in higherpurities.
General Multicomponent Strategy for the Synthesis of 2‐Amino‐1,4‐diazaheterocycles: Scope, Limitations, and Utility
Authors: Kysil Volodymyr , Khvat Alexander , Tsirulnikov Sergey , Tkachenko Sergey , Williams Caroline , Churakova Marina , Ivachtchenko Alexandre 
Published: February 2010

AbstractMulticomponent reactions of primary 1,2‐ and 1,3‐diamines with carbonyl compounds and isocyanides resulting in the formation of diverse 2‐amino‐1,4‐diazaheterocycles are described. Lewis acids (LAs) promote the reactions effectively, and chlorotrimethylsilane (TMSCl) has been found to be a promoter of choice. The scope and limitations of the reactions with regard to each of the components are evaluated and discussed. Post‐IMCR modifications of the synthesized heterocycles have been elaborated.
β,meso‐Acetylenyl‐Bridged, Asymmetrical, Porphyrin Dyads – Synthesis, Spectral, Electrochemical and Computational Studies
Authors: Yedukondalu Meesala , Maity Dilip K. , Ravikanth Mangalampalli 
Published: February 2010

AbstractThe first examples of β,meso‐acetylenyl‐bridged, asymmetrical, covalently linked, porphyrin dyads, containing two different subunits, such as ZnN4P‐N3OP (1), ZnN4P‐N3SP (2), ZnN4P‐N2SOP (4) and ZnN4P‐N2S2P (6), were synthesized by the coupling of a β‐acetylenyl, ZnN4 porphyrin with a meso‐bromoheteroporphyrin under mild, Pd0‐catalyzed, coupling conditions. The dyads containing different types of metal‐free subunits, such as N4P‐N3SP (3), N4P‐N2SOP (5) and N4P‐N2S2P (7), were synthesized by the demetallation of the corresponding dyads. The seven β,meso‐acetylenyl dyads 1–7 were characterized by NMR, MS, absorption, fluorescence and electrochemical techniques. The NMR, absorption and electrochemical studies support an electronic interaction between the subunits in all seven dyads. The steady‐statefluorescence studies on dyads 1–7 support an efficient energy transfer from the donor (ZnN4 or N4) subunit to the acceptor heteroporphyrin subunit upon excitation of the ZnN4/N4 subunit. First‐principle‐based, quantum‐chemical studies carried out on dyads 1, 2, 4 and 6 further support an electronic interaction between the donor and acceptor subunits. The computational studies also predict significant tuning of the electronic energy levels in these dyads with the modification of the porphyrin core of the acceptor groups. The calculations support the experimental results of efficient donor→acceptor energy transfer in these dyads.
Tidal estuary width convergence: Theory and form in North Australian estuaries
Authors: Davies Gareth , Woodroffe Colin D. 
Published: February 2010

AbstractIn order to better understand the relations between tidal estuary shape and geomorphic processes, the width profiles of 79 tidal channels from within 30 estuaries in northern Australia have been extracted from LANDSAT 5 imagery using GIS. Statistics describing the shape and width convergence of individual channels and entire estuaries (which can contain several channels) are analysed along with proxies for the tidal range and fluvial inputs of the estuaries in question. The width profiles of most individual channels can be reasonably approximated with an exponential curve, and this is also true of the width profiles of estuaries. However, the shape of this exponential width profile is strongly related to the mouth width of the system. Channels and estuaries with larger mouths generally exhibit a more pronounced ‘funnel shape’ than those with narrower mouths, reflecting the hydrodynamic importance of the distance over which the channel or estuarine width converges. At the estuarine scale, this ‘convergence length’ also tends to be higher in estuaries which have larger catchments relative to their size. No clear relation between the estuarine width convergence length and tidal range could be discerned within the Northern Australian estuaries although, when these data are combined with data from other studies, a weak relationship emerges. Copyright © 2010 John Wiley & Sons, Ltd.
Critical notch depths for failure of coastal limestone cliffs: case study at Kuro‐shima Island, Okinawa, Japan
Authors: Kogure Tetsuya , Matsukura Yukinori 
Published: February 2010

AbstractDevelopment of a notch at the base of a cliff reduces cliff stability and often induces a collapse. Pleistocene limestone coastal cliffs of elevation 5?m in Kuro‐shima, Ryukyu Islands, have a prominent notch with a depth of 3–4?m at their bases. Around these coastal cliffs, collapses different from previous studies of cliff collapses in the Ryukyu Islands were found; collapses in Kuro‐shima have a horizontal failure surface. The horizontal failure surface, situated at the height of the failure surface corresponding to the retreat point of the notch, is bounded by vertical joints cutting the whole cliff and the reef flat in front of the cliff. Two types of horizontal failure surface were found, triangular and quadrangular; the distinction appears to depend on the angle between the vertical joints and the front face of the cliff. Prior to collapse, these cliffs appear to have been separated from the adjacent cliffs by the development of vertical joints. Consequently, a cliff that will collapse can be identified in advance; cliff instability is strongly dependent on the development of a notch. To study the effect of notch development on cliff collapse, the notch depth at which collapse occurs was calculated using stability analysis. Instability of a cliff increases with notch depth; collapse occurs at the horizontal failure surface when the ratio of the notch depth to the seaward length of the cliff is approximately 0·5–0·7 for a triangular failure surface, and 0·7–0·9 for a quadrangular failure surface. Copyright © 2010 John Wiley & Sons, Ltd.
Causes, consequences and chronology of large‐magnitude palaeoflows in Middle and Late Pleistocene river systems of northwest Europe
Authors: Westaway Rob , Bridgland David R. 
Published: February 2010

AbstractThis study examines the record of high‐palaeoflow phases in river systems in northwest Europe, investigating their causes (whether due to ‘unique’ events, such as the formation of the Dover Strait, or as ‘characteristic’ consequences of climate change), examining their consequences with regard to landscape evolution and possible effects on climate, and determining the chronology of key events. Large‐magnitude palaeoflows, more than an order‐of‐magnitude larger than present‐day flood peaks, are shown to be characteristic of rivers in this region at particular times within the Pleistocene. These events, the most recent of which were during Heinrich events 2 and 1 at ∼25 and ∼17 ka, were evidently caused by the combined effects of glacial outwash, rainfall, snowmelt and melting of permafrost in some proportion. They released such large volumes of water that the thermohaline circulation of the Atlantic Ocean, and thus the climate, may well have been affected. These large‐magnitude palaeoflows are thus a significant aspect of the Pleistocene Earth system that has hitherto gone unquantified. Copyright © 2010 John Wiley & Sons, Ltd.
Rock glacier dynamics in marginal periglacial environments
Authors: Serrano Enrique , de Sanjosé José Juan , González‐Trueba Juan José 
Published: February 2010

AbstractVertical electric sounding, bottom temperature of winter snowcover (BTS) and ground thermal measurement, debris surface analysis and a differential global positioning system (DGPS) survey were performed on the Posets rock glacier (Pyrenees) between 2001 and 2008. High precision records of horizontal and vertical movements of the rock glacier were measured using a DGPS on ten steel rods. Total and annual average displacements and thickness changes for each control point were derived from the field survey. Horizontal and vertical displacement rates in different sectors of the rock glacier were compared, and these compared with thermal, structural and morphological maps. The inferred surface deformation was characterized by extensional and compressive flows in which two dynamic types were found. The first type of movement is defined by the slide and flows related to the existence of an ice body over the frost body. The second dynamic type involved the displacement generated by deformation of the frozen body. The study attempts to understand the surface movement and dynamics of rock glaciers in marginal cold environments and their usefulness as environmental geoindicators. Copyright © 2010 John Wiley & Sons, Ltd.
The antimicrobial triclocarban stimulates embryo production in the freshwater mudsnailPotamopyrgus antipodarum
Authors: Giudice Ben D. , Young Thomas M. 
Published: February 2010

AbstractRecent research has indicated that the antimicrobial chemical triclocarban (TCC) represents a new type of endocrine disruptor, amplifying the transcriptional activity of steroid hormones and their receptors while itself exhibiting little affinity for these receptors. The effects of TCC were studied in the freshwater mudsnail Potamopyrgus antipodarum. Specimens were exposed to concentrations ranging from 0.05 to 10.5 µg/L dissolved TCC and were removed and dissected, and embryos contained within the brood pouch were counted and classified as shelled or unshelled after two and four weeks of exposure. After four weeks, environmentally relevant TCC concentrations of 1.6 to 10.5 µg/L resulted in statistically significant increases in the number of unshelled embryos, whereas 0.2, 1.6, and 10.5 µg/L exposures significantly increased numbers of shelled embryos. The lowest observed effect concentration (LOEC) was 0.2 µg/L, the no observed effect concentration (NOEC) was 0.05 µg/L; the 10% effective concentration (EC10) and the median effective concentration (EC50) for unshelled effects were 0.5 µg/L and 2.5 µg/L, respectively. Given the widespread occurrence of TCC in the environment and the effects shown at environmentally relevant concentrations, these results indicate that TCC may be causing reproductive effects in the environment. Furthermore, the present study indicates that environmental risk from a new class of endocrine-disrupting chemicals (EDCs) is both qualitatively and quantitatively similar to risk from existing classes of EDCs. Environ. Toxicol. Chem. 2010;29:966–970. © 2009 SETAC
Incidence and prognostic impact of secondary cytogenetic aberrations in a series of 145 patients with mantle cell lymphoma
Authors: Espinet Blanca , Salaverria Itziar , Beà Sílvia , Ruiz‐Xivillé Neus , Balagué Olga , Salido Marta , Costa Dolors , Carreras Joaquim , Rodríguez‐Vicente Ana Eugenia , Luís García Juan , Hernández‐Rivas Jesús María , Calasanz María José , Siebert Reiner , Ferrer Ana , Salar Antonio , Carrió Ana , Polo Natividad , García‐Marco José Antonio , Domingo Alicia , González‐Barca Eva , Romagosa Vicenç , Marugán Isabel , López‐Guillermo Armando , Millá Fuensanta , Luís Mate José , Luño Elisa , Sanzo Carmen , Collado Rosa , Oliver Isabel , Monzó Sebastià , Palacín Antonio , González Teresa , Sant Francesc , Salinas Ramon , Ardanaz María Teresa , Font Llorenç , Escoda Lourdes , Florensa Lourdes , Serrano Sergi , Campo Elias , Solé Francesc 
Published: February 2010

AbstractMantle cell lymphoma (MCL) is a mature B‐cell neoplasm with an aggressive behavior, characterized by the t(11;14)(q13;q32). Several secondary genetic abnormalities with a potential role in the oncogenic process have been described. Studies of large MCL series using conventional cytogenetics, and correlating with proliferation and survival, are scarce. We selected 145 MCL cases at diagnosis, displaying an aberrant karyotype, from centers belonging to the Spanish Cooperative Group for Hematological Cytogenetics. Histological subtype, proliferative index and survival data were ascertained. Combined cytogenetic and molecular analyses detected CCND1 translocations in all cases, mostly t(11;14)(q13;q32). Secondary aberrations were present in 58% of patients, the most frequent being deletions of 1p, 13q and 17p, 10p alterations and 3q gains. The most recurrent breakpoints were identified at 1p31‐32, 1p21‐22, 17p13, and 1p36. Aggressive blastoid/pleomorphic variants displayed a higher karyotypic complexity, a higher frequency of 1p and 17p deletions and 10p alterations, a higher proliferation index and poor survival. Gains of 3q and 13q and 17p13 losses were associated with reduced survival times. Interestingly, gains of 3q and 17p losses added prognostic significance to the morphology in a multivariate analysis. Our findings confirm previous observations indicating that proliferation index, morphology and several secondary genetic alterations (3q gains and 13q and 17p losses) have prognostic value in patients with MCL. Additionally, we observed that 3q gains and 17p losses detected by conventional cytogenetics are proliferation‐independent prognostic markers indicating poor outcome. © 2010 Wiley‐Liss, Inc.
Glutamine synthetase deficiency in murine astrocytes results in neonatal death
Authors: He Youji , Hakvoort Theodorus B. M. , Vermeulen Jacqueline L. M. , Labruyère Wilhelmina T. , De Waart D. Rudi , Van Der Hel W. Saskia , Ruijter Jan M. , Uylings Harry B. M. , Lamers Wouter H. 
Published: February 2010

AbstractGlutamine synthetase (GS) is a key enzyme in the “glutamine‐glutamate cycle” between astrocytes and neurons, but its function in vivo was thus far tested only pharmacologically. Crossing GSfl/lacZ or GSfl/fl mice with hGFAP‐Cre mice resulted in prenatal excision of the GSfl allele in astrocytes. “GS‐KO/A” mice were born without malformations, did not suffer from seizures, had a suckling reflex, and did drink immediately after birth, but then gradually failed to feed and died on postnatal day 3. Artificial feeding relieved hypoglycemia and prolonged life, identifying starvation as the immediate cause of death. Neuronal morphology and brain energy levels did not differ from controls. Within control brains, amino acid concentrations varied in a coordinate way by postnatal day 2, implying an integrated metabolic network had developed. GS deficiency caused a 14‐fold decline in cortical glutamine and a sevenfold decline in cortical alanine concentration, but the rising glutamate levels were unaffected and glycine was twofold increased. Only these amino acids were uncoupled from the metabolic network. Cortical ammonia levels increased only 1.6‐fold, probably reflecting reduced glutaminolysis in neurons and detoxification of ammonia to glycine. These findings identify the dramatic decrease in (cortical) glutamine concentration as the primary cause of brain dysfunction in GS‐KO/A mice. The temporal dissociation between GSfl elimination and death, and the reciprocal changes in the cortical concentration of glutamine and alanine in GS‐deficient and control neonates indicate that the phenotype of GS deficiency in the brain emerges coincidentally with the neonatal activation of the glutamine‐glutamate and the associated alanine‐lactate cycles. © 2010 Wiley‐Liss, Inc.