bluuebunny/crossref_metadata_2025_split huggingface dataset:
Odontogenic myxoma: A dual affliction in maxilla and mandible - A case report
Authors: Agrawal Saloni Santosh , Parihar Ajay , Tosh Sujata , Yadav Nidhi 
Published: June 2024

The odontogenic myxoma (OM) is a locally invasive benign odontogenic tumour of the jaws, thought to originate from the mesenchymal portion of the tooth germ. It commonly manifests in individuals during their second or third decade of life.Females experience a higher frequency of occurrences compared to males, and there is a greater inclination for odontogenic myxoma to affect the mandible rather than the maxilla. In most cases, OM manifests as an asymptomatic swelling. Due to its non-capsulated and aggressive nature, there is a notable high recurrence rate reported.Small myxomas are typically addressed through curettage, but it is crucial to conduct thorough follow-up examinations for a minimum of 5 years. The standard treatment for myxoma typically involves surgical resection. Our article highlights two instances of odontogenic myxoma occurring in separate locations. The emphasis is on summarizing distinctive clinical and radiological behaviour of these lesions manifesting in the maxilla and mandible.
Oral melanoacanthoma: A new entity in 2022 WHO
Authors: Rawat Garima , Aiyer Hema Malini 
Published: June 2024

: To highlight the occurrence of Melanoacanthoma in oral cavity. Melanoacanthoma of the oral cavity is rare benign reactive pigmented lesion. It has been recently considered as a distinct entity in the World Health Organization (WHO) classification. Oral melanoacanthomas are reactive and not related to seborrheic keratosis unlike their cutaneous counterparts which are variant of pigmented seborrheic neoplastic in nature. These lesions are characterized by hyperplasia of dendritic melanocytes dispersed throughout an acanthotic epithelium with buccal mucosa being the most common location. An 81-year-old female presented to us with complaint of blackish patch on hard palate. The patient underwent biopsy and the histopathological diagnosis of Melanoacanthoma was given. To the best of our knowledge this is first such case of Melanoacanthoma on the hard palate in Indian subcontinent. : Awareness about these lesions is important for apt diagnosis and preventing under diagnosis.
Oxygen uptake efficiency plateau is unaffected by fitness level - the NOODLE Study
Authors: Kasiak Przemysław , Kowalski Tomasz , Rębiś Kinga , Klusiewicz Andrzej , Sadowska Dorota , Wilk Adrian , Wiecha Szczepan , Barylski Marcin , Poliwczak Adam Rafał , Wierzbiński Piotr , Mamcarz Artur , Śliż Daniel 
Published: June 2024

Abstract

Background
Endurance athletes (EA) are an emerging population of focus for cardiovascular health. The oxygen uptake efficiency plateau (OUEP) is the levelling-off period of ratio between oxygen uptake (VO2) and ventilation (VE). In the cohort of EA, we externally validated prediction models for OUEP and derived with internal validation a new equation.
Methods
140 EA underwent a medical assessment and maximal cycling cardiopulmonary exercise test. Participants were 55% male (N=77, age=21.4±4.8 years, BMI=22.6±1.7 kg·m−2, peak VO2=4.40±0.64 L·min−1) and 45% female (N=63, age=23.4±4.3 years, BMI=22.1±1.6 kg·m−2, peak VO2=3.21±0.48 L·min−1). OUEP was defined as the highest 90-second continuous value of the ratio between VO2 and VE. We used the multivariable stepwise linear regression to develop a new prediction equation for OUEP.
Results
OUEP was 44.2±4.2 mL·L−1 and 41.0±4.8 mL·L−1 for males and females, respectively. In external validation, OUEP was comparable to directly measured and did not differ significantly. The prediction error for males was –0.42 mL·L−1 (0.94%, p=0.39), and for females was +0.33 mL·L−1 (0.81%, p=0.59). The developed new prediction equation was: 61.37–0.12·height (in cm) + 5.08 (for males). The developed model outperformed the previous and explained 12.9% of the variance (R= 0.377, R2= 0.129, RMSE= 4.39 mL·L−1).
Conclusion
OUEP is a stable and transferable cardiorespiratory index. OUEP is minimally affected by fitness level. The predicted OUEP provided promising but limited accuracy among EA. The derived new model is tailored for EA. OUEP could be used to stratify the cardiorespiratory response to exercise and guide training.
What Drives Success when Scaling Innovations? Insights from European Agricultural and Forestry Co-Innovation Actions
Authors: Rivera María , Fieldsend Andrew , Muñoz-Rojas José , Martin Susana , Dijk Lisa Van 
Published: June 2024

Abstract

Agriculture and forestry are facing wicked challenges, driven by a complex set of social, economic and ecological factors. Innovation is a key to devising viable, resilient and sustainable solutions to these challenges but, for innovations to have impact, they need to be ‘scaled’. The current policy context, in the European Union and elsewhere, encourages the use of the ‘interactive’ model of innovation through the so-called ‘multi-actor’ approach. In this study, we explore the dynamics of scaling within agricultural and forestry co-innovation partnerships. Drawing upon evidence from eight co-innovation actions across Europe, encompassing varied contexts, scales and funding mechanisms, we identify four distinct forms of scaling: scaling out, up, deep, and introducing a novel concept, ‘scaling in’. Scaling in reflects the important role in ‘interactive innovation’ of external knowledge flows in optimising the contextual relevance and embedding of innovations. The selection by co-innovation partnerships of strategies and enabling mechanisms in pursuit of scaling is dependent on factors such as funding conditions, contextual norms and partnership objectives. Partnerships need to be clear about the type of scaling they aim to achieve, have an in-depth understanding of contextual complexities, and ensure that scaling is an integral part of the entire project cycle. Co-innovation partnerships can be effective catalysts for transformative change, provided scaling complexities are navigated and enabling mechanisms leveraged adeptly. Our insights advance the understanding of scaling dynamics in co-innovation actions and offer evidence-based strategies for practitioners, policymakers and researchers to bolster the impact of innovation initiatives in agriculture and forestry sectors.
Adaptive sampling using multi-sensor fusion: Marine biodiversity assessments using eDNA metabarcoding and acoustic sensor data
Authors: Veylit Lara , Piarulli Stefania , Farkas Julia , Davies Emlyn J. , Stevenson-Jones Ralph , Aas Marianne , Majaneva Sanna , Hakvåg Sigrid 
Published: June 2024

Abstract

To achieve the aims of the Convention on Biological Diversity’s 2030 Global Biodiversity Framework, marine legislation and management requires the use of cost- and time- effective monitoring of indicator species. Marine observation platforms, which are increasing in popularity globally, are used for such monitoring activities. These platforms allow data to be collected from a variety of sensors simultaneously, providing the opportunity for adapting where and when sampling is performed based on real-time observational data. While some recent monitoring activities are following an adaptive sampling approach, most still employ a more opportunistic method. In this study, we applied an adaptive sampling approach to detect calanoid copepods at seasonally contrasting time points using real-time acoustic sensor data, traditional plankton net sampling, and eDNA metabarcoding. We demonstrate that there are ways to move from sampling opportunistically to a more adaptive sampling approach for more cost- and time- effective monitoring of indicators.
Contact-free magnetic resonance imaging and spectroscopy with acoustic levitation
Authors: Bordes Romain , Argyri Smaragda-Maria , Svenningsson Leo , Guerroudj Feryal , Bernin Diana , Evenäs Lars 
Published: June 2024

Abstract

Conventional magnetic resonance measurements often rely on the use of sample containers. This limits the implementation of time-resolved studies on the molecular level of liquid samples undergoing evaporation, phase transitions, or other dynamic phenomena. Previous attempts to study self-standing droplets in a magnetic field have predominantly focused on buoyancy forces of immiscible liquids[1–3], or molten aluminum beads studied by aerodynamic levitation[4–7]. However, these methods do not allow direct access to the interface and are restricted to non-volatile samples. Recent advancements have explored magnetic resonance studies on surface-resting sessile droplets[8, 9], providing real-time dynamic insights, yet, without granting a fully contact-free environment. In this study, we utilized a demagnetized acoustic levitator to perform magnetic resonance studies on liquid samples in a contact-free manner. Initially, we examined the performance of the levitator inside a 7.05 T magnetic field. Following, magnetic resonance images of the levitator and the levitated samples were acquired, acting as a direct proof of concept. Then, we collected magnetic resonance spectra of the levitated droplets by applying localized and non-localized pulse sequences, and we examined the effect of the droplet shape on the chemical shift. Additionally, we conducted time-resolved experiments on pure solvents and mixtures and captured physical and chemical molecular interactions in real time. This approach allows the implementation of real-time, dynamic, contact-free studies at the molecular level, on a microliter droplet, advancing the scope of magnetic resonance research.
Music Genre Classification using Artificial Neural Networks
Authors: Sood Apoorvi , Rathee Tripti , Bansal Priti , Garg Harsh , Aggarwal Ansh , Tyagi Amrutanshu 
Published: June 2024

Abstract

Music genres play a pivotal role in structuring and interpreting music through shared attributes and traditions. Accurate classification of music genres enhances the overall music experience and enables more precise evaluation of artistic innovation and quality. In this paper, a music genre classification system has been proposed that uses an Artificial Neural Network (ANN) Model, moving beyond the traditional Convolutional Neural Network (CNN) approaches that rely heavily on spectrogram images and require extensive computational resources. Our model focuses on analyzing only the crucial characteristic features of audio files, sidestepping the need for complete spectrogram data. Mel-frequency Cepstral Coefficient (MFCC) has been utilized as the main feature extraction method and is combined with Chroma features and Spectral Contrast. The widely used GTZAN dataset has been utilized. After the extraction of the feature vector, the proposed model classifies the music into different genres. The model exhibited impressive performance with a training accuracy of 98.41% and a validation accuracy of 97.05%, highlighting its effectiveness in accurately classifying music genres.
Factors associated with incomplete tuberculosis preventive treatment: A retrospective analysis of six-years programmatic data in Cambodia
Authors: An Yom , Khun Kim Eam 
Published: June 2024

Abstract

Tuberculosis (TB) preventive treatment (TPT) effectively prevents the progression from TB infection to TB disease. This study explores factors associated with TPT non-completion in Cambodia using 6-years programmatic data (2018-2023) retrieved from the TB Management Information System (TB-MIS). Out of 14,262 individuals with latent TB infection (LTBI) initiated with TPT, 13,963 (97.9%) successfully completed the treatment and 299 (2.1%) did not. Individuals aged between 15-24 years old were more likely to discontinue treatment compared to those aged < 5 years old, with aOR=1.7, p=0.034 and aOR=2, p=0.003, respectively. Compared to the 3-month weekly Isoniazid and Rifapentine (3HP) regimen, the likelihood of TPT discontinuation was high for individuals initiated with 3-month daily Rifampicin and Isoniazid (3RH) (aOR=2.6, p<0.001) and with 6-month daily Isoniazid (6H) (aOR=7, p < 0.001). Those who began TPT at referral hospitals were nearly twice as likely to discontinue the treatment compared to those who started the treatment at health centers (aOR=1.95, p = 0.003). To improve TPT treatment completion, strengthen the treatment follow-up among those aged between 15 and 34 years old and initiated TPT at referral hospitals should be prioritized. The national TB program should consider 3HP the first choice of treatment.
NCAPG mediated CDK1 promotes malignant progression of Non- small cell lung cancer by activating ERK signaling
Authors: Wu Yilin , Yang Ming , Chen Ming , Tian Lan , Zhu Yong , Chen Limin 
Published: June 2024

Abstract

Background
Non-SMC condensing I complex subunit G (NCAPG) has been implicated in tumor progression. However, its role, potential mechanism and prognostic significance in human Non-small cell lung cancer (NSCLC) are elusive.
Methods
Through the conjoint analysis of TCGA and GEO databases, we confirmed that NCAPG is an upregulated gene. The prognostic value of NCAPG was elucidated by data analysis. The functional roles and mechanistic insights of NCAPG in NSCLC growth and metastasis were evaluated in vitro and in vivo.
Results
NCAPG expression was significantly increased in NSCLC. Multivariate Cox regression analysis showed that NCAPG was an independent prognostic factor in patients with NSCLC. The high expression of NCAPG was significantly correlated with lymphatic metastasis. In addition, the high expression of NCAPG effectively promoted the growth and metastasis of NSCLC in vitro and in vivo. In mechanism, the interaction between NCAPG and CDK1 promotes the phosphorylation of ERK.
Conclusion
In general, our results show the key role of NCAPG in NSCLC and highlight the regulatory function of NCAPG / CDK1 / ERK axis in regulating the progression of NSCLC, which provides potential prognosis and therapeutic targets for the treatment of NSCLC.
Identification of superficial invasive and indolent lymphomatous lymph nodes by multiple Ultrasonographic vascular imaging
Authors: Lu Wenjuan , Li Lin , Deng Hongyan , Chen Wenqin , Shu Hua , Zhang Pingyang , Ye Xinhua 
Published: June 2024

Abstract

Objective
This study aimed to explore whether superficial invasive lymphomas and indolent lymphomas could be identified by Ultrasonographic vascular imaging.
Method
A retrospectively study enrolled 82 lymphoma patients. According to proliferation rates and clinical course, the lymph nodes were classified as invasive and indolent lymphomatous lymph nodes. All patients underwent ultrasound (US) with three effective techniques: color Doppler flow imaging (CDFI), angio plus ultrasound imaging (AngioPLUS), and contrast-enhanced ultrasound (CEUS). Qualitative and quantitative parameters from the two groups were compared. Finally, the area under the receiver-operating characteristic (ROC) and regression analysis were used to compare the differences between the two groups and determine the diagnostic efficiency of the three techniques for differentiating invasive lymphoma from indolent lymphoma.
Result
The types of blood flow distribution between invasive and indolent lymphomatous lymph nodes were statistically different in all three Ultrasound techniques. In CDFI, invasive or indolent lymphomatous lymph nodes were determined by resistance index (RI) (p < 0.001). In CEUS, the differences between the two groups in necrosis and arrival time (ATM) (p = 0.026, 0.043) were statistically significant. Finally, CDFI combined with CEUS had the highest diagnostic sensitivity of 98.1%. Interobserver agreements for qualitative parameters were all excellent.
Conclusion
Ultrasonographic Vascular imaging is an aid in identifying invasive and indolent lymphomatous lymph nodes, and CDFI combined with CEUS had the highest diagnostic sensitivity, which can guide clinicians to make more accurate diagnosis and better treatment for patients.
Early Maladaptive Schemas Mediate the Relationship between Severe Childhood Trauma and Eating Disorder Symptoms
Authors: Fasolato Rachele , De Felice Mariangela , Barbui Corrado , Bertani Mariaelena , Bonora Federica , Castellazzi Mariasole , Castelli Silvia , Cristofalo Doriana , Dall’Agnola Rosa Bruna , Ruggeri Mirella , Signoretto Benedetta , Bonetto Chiara 
Published: June 2024

Abstract

Background: Childhood trauma history has frequently been linked to eating disorders (EDs); nevertheless, the scientific literature calls for extending knowledge regarding mediators between EDs and childhood trauma. This study explored whether ED symptoms and early maladaptive schemas were more severe in ED patients with severe childhood trauma than inED patients with no/mild childhood trauma and whether early maladaptive schemas mediated the relationship between childhood trauma and ED symptom severity.
Methods: Data were extracted from the Regional Centre for Eating Disorders registry at the University Hospital of Verona. The extracted data includedself-reported data, including the Eating Disorder Inventory-3 score, Young Schema Questionnaire score, Childhood Experience and Experience of Care and Abuse Questionnaire score, and sociodemographic and clinical information on the ED outpatients seeking care.
Results: Forty-twooutpatients, 30.9% of whom exhibited severe childhood trauma, satisfied the criteria for registry data extraction. The severity of ED symptoms, as well as the early maladaptive schemas’ scores for emotional deprivation, defectiveness, failure, vulnerability, insufficient self-control, and negativity, were greaterin ED outpatients with severe childhood trauma. Furthermore, early maladaptive schemas related to defectiveness, failure, and negativity had a mediatingrole in the relationship between severe childhood trauma and ED symptom severity.
Conclusions: These findings highlightthe importance of early maladaptive schemas in the relationship between trauma history and ED psychopathology. In addition, ED symptoms may represent a dysfunctional attempt to avoid unpleasant emotions associated with schema activation. The results support the need to consider early maladaptive schemas in the treatment of traumatized patients with ED symptoms. Research and clinical implications are discussed.
Optical properties of dissolved organic matter along a salinity gradient from a boreal river estuary to open coastal waters.
Authors: Berezovski Aleksandr , Hessen Dag Olav , Børseth Hanne Halkjelsvik , Andersen Tom 
Published: June 2024

Abstract

This study investigates the optical properties of coloured dissolved organic matter (CDOM) along a salinity gradient from the Glomma river to the outer Oslofjord. The research aims to determine the spectral, isotopic, and quantitative changes in CDOM across this gradient. Key findings indicate that total organic carbon (TOC) concentrations display notable seasonal variability, especially near shore, due to fluctuations in river discharge throughout the year, while remaining more constant in the outer sea environment​​. CDOM absorption, spectral slope and specific absorbance at 443 nm decreases linearly with increasing salinity. CDOM absorption exhibited significant variations, with low-salinity samples showing higher light absorption per unit of carbon, but little seasonal variations, hinting at the fact that CDOM had similar optical properties over the year of sampling. δ13C of TOC analysis revealed a strong positive correlation with salinity, indicating a linear transition from terrestrial to marine organic carbon sources. This method can be an effective way of tracking the fate of terrestrially-derived organic matter in estuarine systems, which is highly topical for coastal darkening research. Water darkening is an increasingly relevant problem affecting many coastal ecosystems, as it is exacerbated by the human activity and climate change.
DNS study of freely-propagating turbulent lean-premixed flames in the broken reaction zone regime
Authors: Zhang Yi , Kang Yinhu , Xu Xinyu , Huang Xiaomei , Zhang Pengyuan , Tang Xiaolin , Lu Xiaofeng 
Published: June 2024

Abstract

The novel engines nowadays featured with higher efficiency are operated under the superpressure, supercritical, supersonic, and near-limit combustion condition that is situated in the broken reaction zone regime. In the broken reaction zone regime, the turbulence Kolmogorov length is shorter than the reaction zone thickness and the fluctuating RMS velocity is higher than the propagating speed, as such small-scale vortex could tear up the continuous front surfaces and the combustion is dispersedly distributed, which is highly deviated off the flamelet theory assumption. Hence, the relevant study would provide some guiding implications for the refinement of turbulent premixed combustion models under the extreme conditions. In this article, the propagation and heat/radical diffusion physics of a high-pressure dimethyl ether (DME)/air turbulent lean-premixed flame with Ka = 200 are investigated numerically by DNS with detailed fuel chemistry and transport model. A wide range of statistical and diagnostic methods, including the Lagrangian fluids tracking, Joint Probability Density Distribution (JPDF), and chemical explosive mode analysis (CEMA) will be applied to reveal the deflagration front structure, the local combustion modes, dynamics evolution, as well as the roles of heat/mass transports and cool/hot flame interaction in the turbulent combustion regimes, which would be beneficial to the design of novel engines with high performances. It is found that in the broken reaction zone regime, the reacting front structure as well as its inner diffusion processes has changed significantly. The reaction zone thickness increases remarkably, and HRR and fuel consumption rate in the cool-flame zone are increased by 16% and 19% respectively. The diffusion effect not only enhances flame propagation, but also suppresses local HRR or fuel consumption. The strong turbulence interplaying with diffusive transports is the underlying physics for the enhancements in cool- and hot-flame fronts. In the turbulence field with strong flame folding and eddy mixing, it created intermixed reacting fronts with various progress variables; the heat/radical diffusions is the underlying mechanism for flame intensification/thickening phenomena. For the cool-flame front, diffusive transports of heat, CH2O, CH3OCH2O2, and CH3OCH3 are of the governing significances for the flame thickening and combustion enhancement. For the hot flame front, heat conductivity is most dominant and the diffusions of CH2O, H2O2, and CH3OCH3 are of less importance with an inhabitation impact.