bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Emotional Dissonance on Turnover Intent in Child Welfare Social Work: Test of a Moderated Mediation Model
Authors: Nielsen Morten Birkeland , Finne Live Bakke , Johannessen Håkon , Christensen Jan Olav 
Published: May 2024

ABSTRACTHigh employee turnover represents a substantial problem in child welfare work. To prevent turnover, knowledge about risk factors, mechanisms, and conditional factors that can explain turnover and turnover intent is highly important. This study investigated a moderated mediation model with (1) emotional dissonance as a predictor of subsequent turnover intent, (2) job dissatisfaction and burnout as potential mediators, and (3) being overly nurturing as a potential moderating variable. The associations were examined using data from a two‐wave prospective questionnaire survey of 424 child welfare workers in Norway. Emotional dissonance was positively related to burnout and job dissatisfaction (cross‐sectionally) and had a significant indirect association with increased turnover intent 6 months later (prospectively) through burnout, but not job dissatisfaction. An antagonistic interaction effect of being overly nurturing was found on the association between emotional dissonance and burnout, and the indirect association with turnover intent. Specifically, having low scores on the overly nurturing trait had a protective effect on burnout and turnover intent in cases of low to moderate exposure to emotional dissonance. In cases of high emotional dissonance, all employees reported the outcomes as equally negative irrespective of their tendency to be overly nurturing. The findings highlight the importance of organizational efforts that can help child welfare workers deal with emotional demands.
Astrocytic HILPDA promotes lipid droplets generation to drive cognitive dysfunction in mice with sepsis‐associated encephalopathy
Authors: Li Ling , Lixia Du , Gan Guifen , Li Jin , Yang Lin , Wu You , Fang Zongping , Zhang Xijing 
Published: May 2024

AbstractAimsSepsis‐associated encephalopathy (SAE) is manifested as a spectrum of disturbed cerebral function ranging from mild delirium to coma. However, the pathogenesis of SAE has not been clearly elucidated. Astrocytes play important roles in maintaining the function and metabolism of the brain. Most recently, it has been demonstrated that disorders of lipid metabolism, especially lipid droplets (LDs) dyshomeostasis, are involved in a variety of neurodegenerative diseases. The aim of this study was to investigate whether LDs are involved in the underlying mechanism of SAE.MethodsThe open field test, Y‐maze test, and contextual fear conditioning test (CFCT) were used to test cognitive function in SAE mice. Lipidomics was utilized to investigate alterations in hippocampal lipid metabolism in SAE mice. Western blotting and immunofluorescence labeling were applied for the observation of related proteins.ResultsIn the current study, we found that SAE mice showed severe cognitive dysfunction, including spatial working and contextual memory. Meanwhile, we demonstrated that lipid metabolism was widely dysregulated in the hippocampus by using lipidomic analysis. Furthermore, western blotting and immunofluorescence confirmed that LDs accumulation in hippocampal astrocytes was involved in the pathological process of cognitive dysfunction in SAE mice. We verified that LDs can be inhibited by specifically suppress hypoxia‐inducible lipid droplet‐associated protein (HILPDA) in astrocytes. Meanwhile, cognitive dysfunction in SAE was ameliorated by reducing A1 astrocyte activation and inhibiting presynaptic membrane transmitter release.ConclusionThe accumulation of astrocytic lipid droplets plays a crucial role in the pathological process of SAE. HILPDA is an attractive therapeutic target for lipid metabolism regulation and cognitive improvement in septic patients.
Recommendations on self‐management interventions for adults living with obesity: COMPAR‐EU project
Authors: Medina‐Aedo Melixa , Beltran Jessica , Valli Claudia , Canelo‐Aybar Carlos , Song Yang , Ballester Marta , Bowman‐Busato Jacqueline , Christogiannis Christos , Grammatikopoulou Maria G. , Groene Oliver , Heijmans Monique , Hoogendorn Martine , Killeen Sarah Louise , Kontouli Katerina‐Maria , Mavridis Dimitris , Miñambres Inka , Mueller Beate Sigrid , Niño de Guzman Ena , Noordman Janneke , Orrego Carola , Perestelo‐Perez Lilisbeth , Saz‐Parkinson Zuleika , Seitidis Georgios , Suñol Rosa , Tsokani Sofia , Alonso‐Coello Pablo 
Published: May 2024

SummarySelf‐management interventions (SMIs) may improve disease management in adults living with obesity. We formulated evidence‐based recommendations for SMIs within the context of the COMPAR‐EU project. The multidisciplinary panel selected critical outcomes based on the COMPAR‐EU core outcome set and established decision thresholds for each outcome. Recommendations were informed by systematic reviews of effects, cost‐effectiveness, and a contextual assessment. To assess the certainty of the evidence and formulate the recommendations, we used the GRADE approach guidance. Overall, SMIs were deemed to have a small impact, but the absence of harmful effects and potential cumulative benefits indicated a favourable balance of effects, despite low certainty. SMIs showed variations in structure, intensity, and resource utilisation, but overall are likely to be cost‐effective. Adapting SMIs to local contexts would enhance equity, acceptability, and feasibility, considering patients' values, and availability of resources and teamwork. Consequently, the panel made conditional recommendations favouring SMIs over usual care. The rigorous and explicit recommendations demonstrated the effectiveness of SMIs for adults living with obesity. However, the gaps in the literature influenced the panel to make only conditional recommendations in favour of SMIs. Further research is needed to strengthen the evidence base and improve recommendations' certainty and applicability.
Global Spillovers of China's Monetary Policy
Authors: Lei Wenni , Mei Dongzhou , Zhang Mi 
Published: May 2024

AbstractSpillovers from China's monetary policy have become increasingly obvious with China's growing importance in the global economy and its close economic and trade ties with the world. This study establishes a proxy structure vector autoregression model to investigate the magnitude and transmission channel of spillovers from China to global and regional economies, taking advantage of high‐frequency changes in asset prices in the financial markets to identify monetary policy shocks. The analysis reveals that China's monetary policy can affect the global economy by influencing international trade and commodity prices but there is no evidence of China's monetary policy affecting global financial variables. Tightness in China's monetary policy can cause a decline in world output whereas expansion in monetary policy can support global trade and output. This study also finds that the response of emerging Asian economies to China's monetary policy shock was nearly twice that of developed economies, while the transmission path did not change. The results of this study are consistent with the stylized fact that China's monetary policy plays an important role in the global trade and commodity cycle, although it does not drive the global financial cycle.
Real time continuous glucose monitoring in high‐risk people with insulin‐requiring type 2 diabetes: A randomised controlled trial
Authors: Lever Claire S. , Williman Jonathan A. , Boucsein Alisa , Watson Antony , Sampson Rachael S. , Sergel‐Stringer Oscar T. , Keesing Celeste , Chepulis Lynne , Wheeler Benjamin J. , de Bock Martin I. , Paul Ryan G. 
Published: May 2024

AbstractAimsTo investigate the impact of real‐time continuous glucose monitoring (rtCGM) on glycaemia in a predominantly indigenous (Māori) population of adults with insulin‐requiring type 2 diabetes (T2D) in New Zealand.MethodsTwelve‐week, multicentre randomised controlled trial (RCT) of adults with T2D using ≥0.2 units/kg/day of insulin and elevated glycated haemoglobin (HbA1c) ≥64 mmol/mol (8.0%). Following a 2‐week blinded CGM run‐in phase, participants were randomised to rtCGM or control (self‐monitoring blood glucose [SMBG]). The primary outcome was time in the target glucose range (3.9–10 mmol/L; TIR) during weeks 10–12, with data collected by blinded rtCGM in the control group.ResultsSixty‐seven participants entered the RCT phase (54% Māori, 57% female), median age 53 (range 16–70 years), HbA1c 85 (IQR 74, 94) mmol/mol (9.9 [IQR 8.9, 10.8]%), body mass index (36.7 ± 7.7 kg/m2). Mean (±SD) TIR increased from 37 (24)% to 53 (24)% [Δ 13%; 95% CI 4.2 to 22; P = 0.007] in the rtCGM group but did not change in the SMBG group [45 (21)% to 45 (25)%, Δ 2.5%, 95% CI −6.1 to 11, P = 0.84]. Baseline‐adjusted between‐group difference in TIR was 10.4% [95% CI −0.9 to 21.7; P = 0.070]. Mean HbA1c (±SD) decreased in both groups from 85 (18) mmol/mol (10.0 [1.7]%) to 64 (16) mmol/mol (8.0 [1.4]%) in the rtCGM arm and from 81 (12) mmol/mol (9.6 [1.1]%) to 65 (13) mmol/mol (8.1 [1.2]%) in the SMBG arm (P < 0.001 for both). There were no severe hypoglycaemic or ketoacidosis events in either group.ConclusionsReal‐time CGM use in a supportive treat‐to‐target model of care likely improves glycaemia in a population with insulin‐treated T2D and elevated HbA1c.
Serum ferritin and risk of colonic neoplasia: Implications for the workup and treatment of iron deficiency
Authors: Urback Adam L. , Martens Kylee , McMurry Hannah Stowe , Sharma Anil , Citti Caitlin , DeLoughery Thomas G. , Shatzel Joseph J. 
Published: May 2024

AbstractIron deficiency is the most common extraintestinal sign of colonic neoplasia, including colorectal cancer (CRC) and other lower gastrointestinal pathology. Both upper endoscopy and colonoscopy is usually recommended in the work‐up of patients with unexplained iron deficiency, particularly in men and postmenopausal women. As the incidence of early‐onset CRC (age <50 years) rises in the United States, there is an increasing need to identify risk predictors to aid in the early detection of CRC. It remains unknown if serum ferritin (SF), and what specific threshold, can be used as a marker to stratify those at risk for CRC and other lower gastrointestinal pathology. In this current review of the literature, we aimed to review guidelines for diagnostic workup of colonic neoplasia in the setting of iron deficiency and examine the association and specific thresholds of SF and risk of CRC by age. Some of the published findings are conflicting, and conclusions specific to younger patients are limited. Though further investigation is warranted, the cumulative findings suggest that SF, in addition to considering the clinical context and screening guidelines, may have potential utility in the assessment of colonic neoplasia.
The olfactory network of larval Xenopus laevis regenerates accurately after olfactory nerve transection
Authors: Hawkins Sara J. , Gärtner Yvonne , Offner Thomas , Weiss Lukas , Maiello Guido , Hassenklöver Thomas , Manzini Ivan 
Published: May 2024

AbstractAcross vertebrate species, the olfactory epithelium (OE) exhibits the uncommon feature of lifelong neuronal turnover. Epithelial stem cells give rise to new neurons that can adequately replace dying olfactory receptor neurons (ORNs) during developmental and adult phases and after lesions. To relay olfactory information from the environment to the brain, the axons of the renewed ORNs must reconnect with the olfactory bulb (OB). In Xenopus laevis larvae, we have previously shown that this process occurs between 3 and 7 weeks after olfactory nerve (ON) transection. In the present study, we show that after 7 weeks of recovery from ON transection, two functionally and spatially distinct glomerular clusters are reformed in the OB, akin to those found in non‐transected larvae. We also show that the same odourant response tuning profiles observed in the OB of non‐transected larvae are again present after 7 weeks of recovery. Next, we show that characteristic odour‐guided behaviour disappears after ON transection but recovers after 7–9 weeks of recovery. Together, our findings demonstrate that the olfactory system of larval X. laevis regenerates with high accuracy after ON transection, leading to the recovery of odour‐guided behaviour.
The effects of intermittent theta burst stimulation over dorsal premotor cortex on primary motor cortex plasticity in young and older adults
Authors: Liao Wei‐Yeh , Opie George M. , Ziemann Ulf , Semmler John G. 
Published: May 2024

AbstractPrevious transcranial magnetic stimulation (TMS) research suggests that the dorsal premotor cortex (PMd) influences neuroplasticity within the primary motor cortex (M1) through indirect (I) wave interneuronal circuits. However, it is unclear how the influence of PMd on the plasticity of M1 I‐waves changes with advancing age. This study therefore investigated the neuroplastic effects of intermittent theta burst stimulation (iTBS) to M1 early and late I‐wave circuits when preceded by iTBS (PMd iTBS‐M1 iTBS) or sham stimulation (PMd sham‐M1 iTBS) to PMd in 15 young and 16 older adults. M1 excitability was assessed with motor evoked potentials (MEP) recorded from the right first dorsal interosseous using posterior–anterior (PA) and anterior–posterior (AP) current TMS at standard stimulation intensities (PA1mV, AP1mV) and reduced stimulation intensities (PA0.5mV, early I‐waves; AP0.5mV, late I‐waves). PMd iTBS‐M1 iTBS lowered the expected facilitation of PA0.5mV (to M1 iTBS) in young and older adults (P = 0.009), whereas the intervention had no effect on AP0.5mV facilitation in either group (P = 0.305). The modulation of PA0.5mV following PMd iTBS‐M1 iTBS may reflect a specific influence of PMd on different I‐wave circuits that are involved in M1 plasticity within young and older adults.
Involvement of the contralateral hippocampus in ictal‐like but not interictal epileptic activities in the kainate mouse model of temporal lobe epilepsy
Authors: Padmasola Guru Prasad , Friscourt Fabien , Rigoni Isotta , Vulliémoz Serge , Schaller Karl , Michel Christoph M. , Sheybani Laurent , Quairiaux Charles 
Published: May 2024

AbstractObjectiveAnimal and human studies have shown that the seizure‐generating region is vastly dependent on distant neuronal hubs that can decrease duration and propagation of ongoing seizures. However, we still lack a comprehensive understanding of the impact of distant brain areas on specific interictal and ictal epileptic activities (e.g., isolated spikes, spike trains, seizures). Such knowledge is critically needed, because all kinds of epileptic activities are not equivalent in terms of clinical expression and impact on the progression of the disease.MethodsWe used surface high‐density electroencephalography and multisite intracortical recordings, combined with pharmacological silencing of specific brain regions in the well‐known kainate mouse model of temporal lobe epilepsy. We tested the impact of selective regional silencing on the generation of epileptic activities within a continuum ranging from very transient to more sustained and long‐lasting discharges reminiscent of seizures.ResultsSilencing the contralateral hippocampus completely suppresses sustained ictal activities in the focus, as efficiently as silencing the focus itself, but whereas focus silencing abolishes all focus activities, contralateral silencing fails to control transient spikes. In parallel, we observed that sustained focus epileptiform discharges in the focus are preceded by contralateral firing and more strongly phase‐locked to bihippocampal delta/theta oscillations than transient spiking activities, reinforcing the presumed dominant role of the contralateral hippocampus in promoting long‐lasting, but not transient, epileptic activities.SignificanceAltogether, our work provides suggestive evidence that the contralateral hippocampus is necessary for the interictal to ictal state transition and proposes that crosstalk between contralateral neuronal activity and ipsilateral delta/theta oscillation could be a candidate mechanism underlying the progression from short‐ to long‐lasting epileptic activities.
Mixed mode I/II and I/III fracture toughness investigation for preplaced aggregate concrete mixtures: Experimental study and theoretical prediction
Authors: Raeisi Roya , Rezaie Freydoon , Aliha M. R. M. 
Published: May 2024

AbstractIn this paper, mixed mode I/II and I/III fracture toughness of preplaced aggregate concrete was studied using an edge‐notched disc bend specimen. The results showed the dependency of the fracture toughness value on the mode mixity. The values of modes I, II, and III fracture toughness were obtained to be equal to
,
, and
, respectively. Several theoretical fracture criteria were examined for predicting the trends of experimental data in the tested preplaced aggregate concrete material. The 3D averaged strain energy density criteria provided the best predictions for the KIIIc/KIc ratio. Mixed mode I/III fracture toughness data were between the predicted envelopes of the maximum tensile stress and 3D maximum tangential strain theories. The generalized maximum tangential stress criterion provided accurate predictions for pure mode II and mixed mode I/II fracture data among the investigated mixed mode fracture criteria. By comparing the preplaced aggregate concrete fracture results with those of other types of concrete, it is observed that preplaced aggregate concrete has acceptable and in‐the‐range fracture resistance.
Clinical HIV outcome trajectories associated with a history of child protective service out‐of‐home care: Longitudinal cohort findings with women living with HIV in Canada
Authors: Logie Carmen H. , Sokolovic Nina , Casale Andrea , Ndung'u Mary , Kennedy V. Logan , Underhill Angela , Fallon Barbara , Cardinal Claudette , Webster Kathleen , Cotnam Jasmine , Kaida Angela , de Pokomandy Alexandra , Loutfy Mona 
Published: May 2024

AbstractObjectivesKnowledge gaps exist regarding the effects of experiencing child protective services (CPS) out‐of‐home care (e.g. foster homes) among women with HIV. We examined whether CPS out‐of‐home care was associated with HIV clinical outcome trajectories among women with HIV in a longitudinal cohort study in Ontario, British Columbia, and Quebec, Canada.MethodsAt three timepoints across 5 years (2013–2018), we examined self‐reported current antiretroviral therapy (ART) use and viral load (VL) detectability (>50 copies/mL). We used latent class growth analysis (LCGA) to identify trajectories of ART use and VL outcomes across study waves. LCGA identifies subgroups (classes) with similar trajectories within the sample. We assessed whether HIV outcome trajectories could be predicted by CPS history. We then conducted a mediation analysis to test whether a mental health latent construct mediated the association between CPS history and detectable VL.ResultsNearly one‐fifth (n = 272; 19%) of participants (n = 1422; mean age 42.8 years) reported CPS out‐of‐home care. Most participants (89%) were in classes that consistently used ART and had an undetectable VL. Individuals with CPS out‐of‐home care histories were twice as likely to have a consistently detectable VL (β = 0.72, p = 0.02); there were no differences in ART use trajectories. In mediation analyses, we found an indirect path from CPS history to a consistently detectable VL via baseline mental health status (β = 0.02, 95% confidence interval 0.005–0.04, p = 0.02), with a significant odds ratio (1.12, z = 2.43, p = 0.02).ConclusionAmong women with HIV in Canada, experiencing childhood CPS out‐of‐home care was associated with a reduced likelihood of achieving viral suppression, via poorer mental health.
Beyond mixed embeddedness: Multilevel personal networks of migrant entrepreneurs in Naples and Manchester
Authors: Fraudatario Maria Camilla , Giordano Giuseppe , Zaccaria Anna Maria 
Published: May 2024

AbstractThis article analyses immigrant entrepreneurship in different urban contexts and recognizes its significant impact on the economic and sociocultural development of cities. Immigrant entrepreneurs are often concentrated in neighbourhoods and promote diversified economic activities. The mixed embeddedness (ME) framework highlights the complex interplay of contextual, economic and institutional factors that shape immigrant entrepreneurship. As a source of social capital, entrepreneurial networks provide access to resources and opportunities. Despite all progress, the systematic analysis and quantification of embeddedness among immigrant entrepreneurs remains a challenge. This article aims to understand how different urban contexts shape various entrepreneurial strategies by quantifying forms of embeddedness. To pursue this goal, we examined the entrepreneurial strategies of Sri Lankans in Rione Sanità (Naples, Italy) and Pakistani entrepreneurs in Rusholme (Manchester, United Kingdom). By using social network analysis, this article reveals distinct forms of embeddedness and how the characteristics of urban contexts and groups simultaneously help define differences in entrepreneurial strategies.
Evaluating the impact of pulsed light treatment on microbial and enzyme inactivation and quality attributes in fresh‐cut watermelon
Authors: Jaiswal Monica , Srivastava Brijesh 
Published: May 2024

AbstractThis study investigated the impact of pulsed light (PL) applied at a fluence of 4–12 J cm−2 (complying with U.S. Food and Drug Administration standards) on fresh‐cut watermelon, focusing on its efficacy in inactivating various food‐borne pathogenic gram‐positive (Escherichia coli and Staphylococcus aureus) and gram‐negative (Listeria monocytogenes and Salmonella) bacteria. The inactivation data were used to fit the log‐linear and Weibull kinetic models. Additionally, the impact of PL on physicochemical properties, lycopene content, total phenolic content, antioxidant activity, and pectin methylesterase (PME) residual activity (RA) was studied. The results demonstrated that the inactivation rate increases with the increase in fluence. Salmonella was most sensitive to PL, resulting in a reduction of 2.55 ± 0.08 log CFU g−1 and a higher kmax, whereas S. aureus was most resistant, with a reduction of 1.87 ± 0.24 log CFU g−1 and a lower kmax. The Weibull model was the best to predict the inactivation kinetics based on standard statistics and information theory criteria. For all assayed food‐borne pathogens, the inactivation curve showed non‐linearity with upward concavity except for L. monocytogenes, which followed a concave downward curve (β >1). Results showed that PL was effective in the retention of color, firmness, pH levels, total soluble solids, and titratable acidity, and also had a positive effect on enhancing the levels of essential components such as lycopene, total phenolic compounds, and antioxidant activity. Additionally, the PME RA significantly decreased with an increase in fluence due to structural modification. Therefore, PL can be explored to enhance fresh‐cut watermelon's safety and quality attributes.Practical ApplicationsThe implementation of this research holds significant potential for practical benefits in the fresh‐cut fruit industry. The findings could revolutionize processing practices, ensuring enhanced microbial safety, enzyme inactivation, and an extended shelf‐life of fresh‐cut watermelon. The study strongly contributes to preserving the desirable texture, color, and overall quality of the product, enhancing the retention of lycopene and other valuable antioxidants by standardizing the pulsed light treatment parameters while adhering to U.S. Food and Drug Administration standards for food application. Moreover, this research will scientifically contribute to addressing the critical challenges of foodborne outbreaks in the fresh‐cut fruit sector while providing consumers with a healthy, convenient food choice.