bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety of subcutaneous immunotherapy with Novo-Helisen-Depot in the children: a retrospective analysis from a single center in Northern China
Authors: Zhou Qianlan , Liu Si , Dai Bing , Chen Li , Han Lina , Zhang Qinzhen , Shen Wenxin , Shan Lishen 
Published: April 2024

BackgroundLittle is known about the safety of mite extract product Novo-Helisen Depot (NHD) as subcutaneous immunotherapy (SCIT) in the children with mite allergy especially immediate/late local reaction (LRs).MethodsWe conducted a retrospective study analyzing the adverse events of the children undergoing subcutaneous immunotherapy with NHD. Adverse events included local and systemic adverse reactions (SRs) at the very early and late stage. The correlation of the basic characteristics, laboratory analysis results, LRs and SRs were analyzed.ResultsTwo hundred and eighty-seven patients received at least 15 months of subcutaneous immunotherapy with NHD were included in the analysis. Skin-prick testing (SPT) results of D. pteronyssinus was associated with an increased risk of immediate LRs in build-up phase (OR = 1.53, 95% CI: 1.02, 2.37) and delayed LRs in maintenance phase (OR = 1.58, 95% CI: 1.05, 2.46), while SPT results of D. farinae was associated with an increased risk of SRs (OR = 3.22, 95% CI: 1.17, 10.00) and severe SRs (OR = 7.68, 95% CI: 1.13, 109.50). Serum IgE level of D. pteronyssinus was associated with an increased risk of SRs (OR = 1.01, 95% CI: 1.00, 1.03). Patients with both asthma and allergic rhinitis was associated with an increased risk of SR, and severe SRs (P &lt; 0.05).ConclusionNHD as SCIT is safe. The children with higher SPT level with D. farinae or D. pteronyssinus, higher serum IgE level of D. pteronyssinus, children with both asthma and allergic rhinitis, and the children with treatment interruption had higher risk of adverse events.
Clinical characteristics and rehabilitation potential in children with cerebral palsy based on MRI classification system
Authors: Yang Jie , Chen Congjie , Chen Ningning , Zheng Helin , Chen Yuxia , Li Xiaoli , Jia Qingxia , Li Tingsong 
Published: April 2024

BackgroundThe correlation of clinical characteristics of cerebral palsy (CP) and the magnetic resonance imaging classification system (MRICS) for (CP) is inconsistent. Specifically, the variance in rehabilitation potential across MRICS remains underexplored.AimsTo investigate the clinical characteristics and potential for rehabilitation in children with CP based on MRICS.Materials and methodsChildren with CP admitted to the Department of Rehabilitation, Children's Hospital of Chongqing Medical University between 2017 and 2021 were included in the study. Qualified cases underwent a follow-up period of at least one year. The clinical characteristics of CP among different MRICS were analyzed, then the rehabilitation potential was explored by a retrospective cohort study.ResultsAmong the 384 initially enrolled children, the male-to-female ratio was 2.3:1, and the median age of diagnosis was 6.5 months (interquartile range: 4–12). The most prevalent MRICS categorization was predominant white matter injury (40.6%), followed by miscellaneous (29.2%) and predominant gray matter injury (15.6%). For the predominant white matter injury and miscellaneous categories, spastic diplegia emerged as the leading subtype of CP, with incidences of 59.6% and 36.6%, respectively, while mixed CP (36.7%) was the most common type in children with predominant gray matter. Notably, 76.4% of children with predominant white matter injury were classified as levels I–III on the gross motor function classification system (GMFCS), indicating significantly less severity than other groups (χ2 = 12.438, p = 0.013). No significant difference across MRICS categories was observed for the manual ability classification system (MACS) (H = 8.176, p = 0.085). Rehabilitation potential regarding fine motor function and adaptability based on Gesell assessment was dependent on MRICS over the follow-up period. Children with normal MRI scans exhibited superior rehabilitation outcomes. Commencing rehabilitation at an earlier stage produced consistent and beneficial results in terms of fine motor function and adaptability across all MRICS categories. Moreover, participants below 2 years of age demonstrated enhanced rehabilitation potential regarding fine motor outcomes and adaptability within the MRICS framework.ConclusionMRICS displayed a significant association with clinical characteristics and rehabilitation efficacy in children with CP.
The effects of slow wave sleep characteristics on semantic, episodic, and procedural memory in people with epilepsy
Authors: Höller Yvonne , Eyjólfsdóttir Stefanía , Van Schalkwijk Frank Jasper , Trinka Eugen 
Published: April 2024

Slow wave sleep (SWS) is highly relevant for verbal and non-verbal/spatial memory in healthy individuals, but also in people with epilepsy. However, contradictory findings exist regarding the effect of seizures on overnight memory retention, particularly relating to procedural and non-verbal memory, and thorough examination of episodic memory retention with ecologically valid tests is missing. This research explores the interaction of SWS duration with epilepsy-relevant factors, as well as the relation of spectral characteristics of SWS on overnight retention of procedural, verbal, and episodic memory. In an epilepsy monitoring unit, epilepsy patients (N = 40) underwent learning, immediate and 12 h delayed testing of memory retention for a fingertapping task (procedural memory), a word-pair task (verbal memory), and an innovative virtual reality task (episodic memory). We used multiple linear regression to examine the impact of SWS duration, spectral characteristics of SWS, seizure occurrence, medication, depression, seizure type, gender, and epilepsy duration on overnight memory retention. Results indicated that none of the candidate variables significantly predicted overnight changes for procedural memory performance. For verbal memory, the occurrence of tonic-clonic seizures negatively impacted memory retention and higher psychoactive medication load showed a tendency for lower verbal memory retention. Episodic memory was significantly impacted by epilepsy duration, displaying a potential nonlinear impact with a longer duration than 10 years negatively affecting memory performance. Higher drug load of anti-seizure medication was by tendency related to better overnight retention of episodic memory. Contrary to expectations longer SWS duration showed a trend towards decreased episodic memory performance. Analyses on associations between memory types and EEG band power during SWS revealed lower alpha-band power in the frontal right region as significant predictor for better episodic memory retention. In conclusion, this research reveals that memory modalities are not equally affected by important epilepsy factors such as duration of epilepsy and medication, as well as SWS spectral characteristics.
Noninvasive cardiac-specific biomarkers for the diagnosis and prevention of vascular stenosis in cardiovascular disorder
Authors: Pulukool Sujith Kumar , Srimadh Bhagavatham Sai Krishna , Vijay Sudarshan K. , Almansour Abdulrahman I. , Chaudhary Sandeep , Abuyousef Farah , Saleh Na’il , Tripathi Pratima 
Published: April 2024

Background:The most frequent lesion in the blood vessels feeding the myocardium is vascular stenosis, a condition that develops slowly but can prove to be deadly in a long run. Non-invasive biomarkers could play a significant role in timely diagnosis, detection and management for vascular stenosis events associated with cardiovascular disorders.Aims:The study aimed to investigate high sensitivity troponin I (hs-TnI), cardiac troponin I (c-TnI) and high sensitivity C-reactive protein (hs-CRP) that may be used solely or in combination in detecting the extent of vascular stenosis in CVD patients.Methodology:274 patients with dyspnea/orthopnea complaints visiting the cardiologists were enrolled in this study. Angiographic study was conducted on the enrolled patients to examine the extent of stenosis in the five prominent vessels (LDA, LCX, PDA/PLV, RCA, and OM) connected to the myocardium. Samples from all the cases suspected to be having coronary artery stenosis were collected, and subjected to biochemical evaluation of certain cardiac inflammatory biomarkers (c-TnI, hsTn-I and hs-CRP) to check their sensitivity with the level of vascular stenosis. The extent of mild and culprit stenosis was detected during angiographic examination and the same was reported in the form significant (≥50% stenosis in the vessels) and non-significant (&lt;50% stenosis in the vessels) Carotid Stenosis. Ethical Clearance for the study was provided by Dr. Ram Manohar Lohia Institute of Medical Sciences Institutional Ethical Committee. Informed consent was obtained from all the participants enrolled in the study.Results:We observed that 85% of the total population enrolled in this study was suffering from hypertension followed by 62.40% detected with sporadic episodes of chest pain. Most of the subjects (42% of the total population) had stenosis in their LAD followed by 38% who had stenosis in their RCA. Almost 23% patients were reported to have stenosis in their LCX followed by OM (18% patients), PDA/PLV (13%) and only 10% patients had blockage problem in their diagonal. 24% of the subjects were found to have stenosis in a single vessel and hence were categorized in the Single Vessel Disease (SVD) group while 76% were having stenosis in two or more than two arteries (Multiple Vessel Disease). hs-TnI level was found to be correlated with the levels of stenosis and was higher in the MVD group as compared to the SVD group.Conclusion:hs-TnI could be used as a novel marker as it shows prominence in detecting the level of stenosis quite earlier as compared to c-TnI which gets detected only after a long duration in the CVD patients admitted for angiography. hs- CRP gets readily detected as inflammation marker in these patients and hence could be used in combination with hs-TnI to detect the risk of developing coronary artery disease.
The coronavirus disease 2019 infodemic: a concept analysis
Authors: Choi Sujin 
Published: April 2024

AimThis study aimed to analyze the coronavirus disease 2019 (COVID-19) infodemic phenomenon in the medical field, providing essential data to help healthcare professionals understand it.MethodsThis study utilized a hybrid model for concept analysis. In the theoretical phase (first phase), a literature review was conducted using ScienceDirect, PubMed, CINAHL, ProQuest, Scopus, Web of Science, DBpia, RISS, and KISS. Semi-structured interviews, involving eight physicians and six nurses, were used in the fieldwork phase (second phase). In the final analysis phase (third phase), the results of the preceding phases were combined.ResultsBased on the findings of these phases, the COVID-19 infodemic can be defined as “the phenomenon of information flood, reproduction, dissemination, and asymmetry, which occurred during the pandemic through social networks among the public lacking essential knowledge of infectious disease, and is associated with negative and positive effects.”ConclusionOur findings can help the Ministry of Health and Welfare and healthcare professionals to understand the phenomenon of the infodemic and prepare necessary strategies and education programs for the public. Therefore, the provision of basic data is important for developing influential roles for healthcare professionals during infectious disease outbreaks.
Para sport and anti-doping: a study of Swedish Para athletes' experiences and perceptions
Authors: Qvarfordt Anna , Svedsäter Göran , Fagher Kristina , Bjerkefors Anna , Blomqvist Sven 
Published: April 2024

IntroductionA well-functioning anti-doping system relies on being perceived by athletes as effective, fair, and practically feasible to implement. While research has highlighted the views of Olympic athletes on anti-doping over the past decade, the experiences and perceptions of Para athletes have not been extensively explored. The purpose of this study was to examine Swedish elite Para athletes' experiences and perceptions of the policy and practice of the anti-doping system.MethodsA quantitative cross-sectional approach was used, with a web survey elaborated from a survey with Olympic athletes adjusted for Para athletes with physical, visual, and intellectual impairments. The sample consisted of 66 active Para athletes competing at national or international level (response rate 71%). Data were analyzed using descriptive statistics and differences between subgroups were examined Fisher's exact test. Thematic analysis was employed to analyze open-ended questions.ResultsMost of the respondents expressed a positive outlook on the anti-doping system, advocating for comprehensive efforts. A significant portion (35%) had not received anti-doping education, with those who did reporting increased confidence in avoiding unintentional doping. Despite their elite status, half of the respondents had not undergone doping control. Mistrust regarding the system's effectiveness and fairness was identified, with over half of the participants emphasizing the need for new technical solutions to enhance procedures specifically tailored for Para athletes.DiscussionThe athletes in this study advocate for a Para sports-focused approach in the anti-doping system, emphasizing equal testing opportunities, procedural adjustments for independence and privacy, and increased access to education. The findings illuminate the unique conditions faced by athletes with impairments within the anti-doping system, offering valuable insights for policymaking in the development of anti-doping strategies tailored to Para athletes and their various impairments.
Patients' views on primary care multidisciplinary teams in Scotland: a mixed-methods evaluation
Authors: Sweeney Kieran D , Donaghy Eddie , Henderson David , Wang Harry HX , Thompson Andrew , Guthrie Bruce , Mercer Stewart W 
Published: April 2024

Background
Expanding primary care multidisciplinary teams (MDTs) was a key component of the 2018 Scottish GP contract, with more than 4700 MDT staff appointed since then.

Aim
To explore patients’ views on primary care MDT expansion in Scotland.

Design & setting
A mixed-methods evaluation, which included a postal survey and semi-structured telephone interviews with patients in Scotland.

Method
A survey was undertaken of patients who had recently consulted a GP in deprived urban, affluent urban, and remote and rural areas, assessing awareness of five MDT roles and attitudes towards receptionist signposting. In addition, 30 individual interviews were conducted, exploring patients' MDT-care experiences.

Results

Of 1053 survey responders, most were unaware of the option of MDT rather than GP consultations for three out of five roles (69% unaware of link worker appointments; 69% mental health nurse; and 58% pharmacist). Reception signposting was less popular in deprived urban areas (34% unhappy versus 29% in remote and rural versus 21% affluent urban;
P
<0.001), and in patients with multimorbidity (31% unhappy versus 24% in non-multimorbid;
P
<0.05). Just over two-thirds of interviewees had multimorbidity and almost all reported positive MDT-care experiences. However, MDT care was generally seen as a supplement rather than a substitute for GP care. Around half of patients expressed concerns about reception signposting. These patients were more likely to also express concerns about GP access in general. Both of these concerns were more common in deprived urban areas than in remote and rural or affluent urban areas.

Conclusion
MDT care has expanded in Scotland with limited patient awareness. Although patients understand its potential value, many are unhappy with reception signposting to first-contact MDT care, especially those in deprived urban areas living with multimorbidity. This represents a barrier to the aims of the new GP contract.
Dossiers relatifs à la restauration de Place-Royale de Québec (1955-1990) : pour une archéologie du papier
Authors: Yoakim William 
Published: April 2024

Il est particulièrement difficile de saisir la nature exacte des archives et du fonds. Reflets objectifs des activités accomplies pour certains ou constructions sociales et produits de contextes spécifiques pour d’autres, ces deux notions majeures de l’archivistique ne cessent de faire couler beaucoup d’encre. Face à cet important débat théorique, il importe d’aller sur le terrain et de se confronter directement aux documents d’archives et à leur matérialité.
Commencé au cours des années 1960, le chantier de restauration de Place-Royale de Québec devient rapidement un vaste scandale patrimonial. La volonté de transformer les maisons pour retrouver le style architectural français du temps de la «Nouvelle France » ne fait pas l’unanimité et plusieurs experts parlent de la création d’un Disneyland québécois. L’accumulation des critiques et des scandales fait que ce chantier va connaître de nombreux rebondissements qui vont profondément impacter son déroulement.
Les archives du projet de restauration de Place-Royale constituent alors un terrain favorable pour analyser l’impact du contexte sur la mise en archives d’une activité. Dans cette quête sur l’origine d’un ensemble documentaire, une véritable archéologie de papier se basant en partie sur la matérialité des archives est souvent nécessaire.
Lire le chant VIII de l’Énéide avec les commentateurs : le regard de Tiberius Claudius Donat
Authors: Clément-Tarantino Séverine 
Published: April 2024

It is always useful, when we read a text, to pay attention to its commentaries, ancient as well as modern. It is not always easy to grasp the interpretations that underlie most of these commentaries. Even ancient commentaries are somewhat tendentious and Tiberius Claudius Donatus’ commentary on the Aeneid (the Interpretationes Vergilianae) well demonstrates this fact, its basic thesis being that Virgil’s poem is rather a laudatory speech. Now Donatus’ interpretation can bring us a lot, because it invites us to pay more attention to details that we would not have read in a laudatory perspective or that we would not have examined at all. He is prone to weighing up every single word used by Virgil and the way he looks at the text can sharpen our own attention. His commentary on the eight book of the Aeneid counts many examples of this tendency, and besides, the attention Donatus pays to some major themes (sc. themes that he identifies as major
in this book, as he does in others) is worthy of interest. Among these themes, poverty appears to be the most important. In fact, Donatus resists apparently to the valorization of humility – he himself denies that true poverty is addressed in the episode at Pallanteum – and rather preserves Aeneas’greatness.
SARS-COV-2: RESPOSTA IMUNE E O PANORAMA SOBRE OS POTENCIAIS TRATAMENTOS PARA COVID-19
Authors: Campos Anna Júlia Alves da Silva , Duarte Lara Maia , Hostalácio Stela Firmino Soares , Oliveira Bruno Cabral de Lima 
Published: April 2024

Analisar os aspectos imunopatológicos associados à infecção pelo SARS-CoV-2, além de discutir as potenciais ferramentas terapêuticas direcionadas aos componentes imunológicos. Método: Trata-se de uma revisão bibliográfica, com buscas realizadas na base de dados PubMed. Foram definidos critérios de inclusão para artigos que investigassem diretamente a resposta imunológica e inflamatória à infecção pelo SARS-CoV-2, excluindo revisões, artigos em idiomas diferentes do inglês e aqueles não relacionados ao sistema imunológico ou à resposta inflamatória. Após uma busca inicial, 735 artigos foram identificados e submetidos a uma triagem com base nos critérios estabelecidos. Ao final , 65 artigos foram selecionados para a revisão final. Resultados: O estudo revelou que os níveis de LDH e PCR diminuíram durante a hospitalização, enquanto a contagem de neutrófilos diminuiu nos pacientes críticos, indicando uma mudança na resposta imunológica. Diversas abordagens terapêuticas, como anticorpos monoclonais e células mesenquimais, foram exploradas para modular a resposta inflamatória, apesar das limitações logísticas e de disponibilidade. Conclusão: São necessários mais estudos para entender o comportamento do SARS-CoV-2 em pacientes graves e suas mutações, visando abordagens terapêuticas baseadas em evidências científicas.

Este artigo tem por objetivo realizar uma abordagem abrangente dos aspectos imunopatológicos associados à infecção pelo SARS-CoV-2, discutindo, além disso, as possíveis ferramentas terapêuticas direcionadas aos componentes imunológicos. Foi utilizado como motor de busca a base de dados PubMed para seleção dos artigos, através dos descritores "SARS-CoV-2", "Coronavírus", "COVID-19" e "immune response", "immunity", "immunological markers", "inflammation", "Inflammatory response". Conclui-se que, a partir do estudo da imunologia do SARS-CoV-2, o uso de anticorpos monoclonais, células mesenquimais e outros tratamentos abordados são efetivos em pacientes críticos com o vírus, apesar de desafios logísticos e de disponibilidade.
Evaluación Formativa En Matemáticas: Una Propuesta Para El Desarrollo De Competencias Evaluativas En Docentes De Instituciones Públicas En Colombia
Authors: Camargo Arias Jesús Antonio , Canabal Guzmán Javier Darío 
Published: April 2024

El presente articulo tiene la intención de publicar un resumen sobre los avances investigativos (específicamente del marco contextual, teórico y metodológico) para el desarrollo de una propuesta orientada al diseño de un programa de formación docente que contribuya con la adquisición teórica de mecanismos de aplicación del proceso de la evaluación formativa en el marco de la educación por competencias para el área de Matemáticas. La idea surge a partir de la necesidad de aplicar de cara al futuro un enfoque evaluativo que permita simultáneamente desarrollar competencias (que por cierto actualmente no se están en un nivel deseado, así se puede establecer a partir de los resultados obtenidos en las competencias evaluadas en las pruebas aplicadas por el estado), para así de esta manera valorar el progreso de los estudiantes, pero redireccionando permanentemente los procesos de enseñanza y de aprendizaje como resultado de una reflexión continua sobre la praxis educativa. Para ello se proponen una serie de fases en la ejecución del proceso investigativo que den inicialmente la posibilidad de caracterizar las debilidades y fortalezas del procesos evaluativo que se viene desarrollando en las instituciones educativas públicas de la ciudad, desde la perspectiva de los estudiantes, docentes e instituciones (los tres se constituyen como las unidades de estudio de la población), para luego así construir la propuesta formativa dirigida a docentes. En ese orden de ideas se opta por aplicar en la metodología la perspectiva de la comprensión holística, ya que esta permite articular de manera coherente y simultánea diversos epistemes, métodos, herramientas de recolección y análisis de información; que de otra forma no sería posible desarrollar, considerando la reducción epistémica que se da al escoger un solo enfoque. Seguidamente se propone implementar como método de investigación el holopráxico y se eligen como herramientas de recolección de información (luego de la previa determinación de las categorías apriorísticas) la encuesta, entrevista semiestructurada, observación directa y la revisión documental.