bluuebunny/crossref_metadata_2025_split huggingface dataset:
Syndecan-1 antigen, a promising new target for triple-negative breast cancer immuno-PET and radioimmunotherapy. A preclinical study on MDA-MB-468 xenograft tumors
Authors: Rousseau Caroline , Ruellan Anne Lise , Bernardeau Karine , Kraeber-Bodéré Françoise , Gouard Sebastien , Loussouarn Delphine , Saï-Maurel Catherine , Faivre-Chauvet Alain , Wijdenes John , Barbet Jacques , Gaschet Joëlle , Chérel Michel , Davodeau François 
Published: September 2011

Abstract

Background
Overexpression of syndecan-1 (CD138) in breast carcinoma correlates with a poor prognosis and an aggressive phenotype. The objective of this study was to evaluate the potential of targeting CD138 by immuno-PET imaging and radioimmunotherapy (RIT) using the antihuman syndecan-1 B-B4 mAb radiolabeled with either 124I or 131I in nude mice engrafted with the triple-negative MDA-MB-468 breast cancer cell line.

Method
The immunoreactivity of 125I-B-B4 (80%) was determined, and the affinity of 125I-B-B4 and the expression of CD138 on MDA-MB-468 was measured in vitro by Scatchard analysis. CD138 expression on established tumors was confirmed by immunohistochemistry. A biodistribution study was performed in mice with subcutaneous MDA-MB-468 and 125I-B-B4 at 4, 24, 48, 72, and 96 h after injection and compared with an isotype-matched control. Tumor uptake of B-B4 was evaluated in vivo by immuno-PET imaging using the 124I-B-B4 mAb. The maximum tolerated dose (MTD) was determined from mice treated with 131I-B-B4 and the RIT efficacy evaluated.

Results

125I-B-B4 affinity was in the nanomolar range (Kd = 4.39 ± 1.10 nM). CD138 expression on MDA-MB-468 cells was quite low (Bmax = 1.19 × 104 ± 9.27 × 102 epitopes/cell) but all expressed CD138 in vivo as determined by immunohistochemistry. The tumor uptake of 125I-B-B4 peaked at 14% injected dose (ID) per gram at 24 h and was higher than that of the isotype-matched control mAb (5% ID per gram at 24 h). Immuno-PET performed with 124I-B-B4 on tumor-bearing mice confirmed the specificity of B-B4 uptake and its retention within the tumor. The MTD was reached at 22.2 MBq. All mice treated with RIT (n = 8) as a single treatment at the MTD experienced a partial (n = 3) or complete (n = 5) response, with three of them remaining tumor-free 95 days after treatment.

Conclusion
These results demonstrate that RIT with 131I-B-B4 could be considered for the treatment of metastatic triple-negative breast cancer that cannot benefit from hormone therapy or anti-Her2/neu immunotherapy. Immuno-PET for visualizing CD138-expressing tumors with 124I-B-B4 reinforces the interest of this mAb for diagnosis and quantitative imaging.
Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort
Authors: Smith Katherine R , Suppiah Vijayaprakash , O'Connor Kate , Berg Thomas , Weltman Martin , Abate Maria Lorena , Spengler Ulrich , Bassendine Margaret , Matthews Gail , Irving William L , Powell Elizabeth , Riordan Stephen , Ahlenstiel Golo , Stewart Graeme J , Bahlo Melanie , George Jacob , Booth David R ,   the International Hepatitis C Genetics Consortium (IHCGC)
Published: September 2011

Abstract
Background
The hepatitis C virus (HCV) infects nearly 3% of the World's population, causing severe liver disease in many. Standard of care therapy is currently pegylated interferon alpha and ribavirin (PegIFN/R), which is effective in less than half of those infected with the most common viral genotype. Two IL28B single nucleotide polymorphisms (SNPs), rs8099917 and rs12979860, predict response to (PegIFN/R) therapy in treatment of HCV infection. These SNPs were identified in genome wide analyses using Illumina genotyping chips. In people of European ancestry, there are 6 common (more than 1%) haplotypes for IL28B, one tagged by the rs8099917 minor allele, four tagged by rs12979860.

Methods
We used massively parallel sequencing of the IL28B and IL28A gene regions generated by polymerase chain reaction (PCR) from pooled DNA samples from 100 responders and 99 non-responders to therapy, to identify common variants. Variants that had high odds ratios and were validated were then genotyped in a cohort of 905 responders and non-responders. Their predictive power was assessed, alone and in combination with HLA-C.

Results
Only SNPs in the IL28B linkage disequilibrium block predicted drug response. Eighteen SNPs were identified with evidence for association with drug response, and with a high degree of confidence in the sequence call. We found that two SNPs, rs4803221 (homozygote minor allele positive predictive value (PPV) of 77%) and rs7248668 (PPV 78%), predicted failure to respond better than the current best, rs8099917 (PPV 73%) and rs12979860 (PPV 68%) in this cross-sectional cohort. The best SNPs tagged a single common haplotype, haplotype 2. Genotypes predicted lack of response better than alleles. However, combination of IL28B haplotype 2 carrier status with the HLA-C C2C2 genotype, which has previously been reported to improve prediction in combination with IL28B, provides the highest PPV (80%). The haplotypes present alternative putative transcription factor binding and methylation sites.

Conclusions
Massively parallel sequencing allowed identification and comparison of the best common SNPs for identifying treatment failure in therapy for HCV. SNPs tagging a single haplotype have the highest PPV, especially in combination with HLA-C. The functional basis for the association may be due to altered regulation of the gene. These approaches have utility in improving diagnostic testing and identifying causal haplotypes or SNPs.
Advanced dental disease in people with severe mental illness:
systematic review and meta-analysis
Authors: Kisely Steve , Quek Lake-Hui , Pais Joanne , Lalloo Ratilal , Johnson Newell W. , Lawrence David 
Published: September 2011

BackgroundPsychiatric patients have increased comorbid physical illness. There is
less information concerning dental disease in this population in spite of
risk factors including diet and psychotropic side-effects (such as
xerostomia).AimsTo compare the oral health of people with severe mental illness with that
of the general population.MethodA systematic search for studies from the past 20 years was conducted
using Medline, PsycINFO, Embase and article bibliographies. Papers were
independently assessed. The primary outcome was total tooth loss
(edentulousness), the end-stage of both untreated caries and periodontal
disease. We also assessed dental decay through standardised measures: the
mean number of decayed, missing and filled teeth (DMFT) or surfaces
(DMFS). For studies lacking a control group we used controls of similar
ages from a community survey within 10 years of the study.ResultsWe identified 21 papers of which 14 had sufficient data
(n = 2784 psychiatric patients) and suitable controls
(n = 31 084) for a random effects meta-analysis.
People with severe mental illness had 3.4 times the odds of having lost
all their teeth than the general community (95% CI 1.6–7.2). They also
had significantly higher scores for DMFT (mean difference 6.2, 95% CI
0.6–11.8) and DMFS (mean difference 14.6, 95% CI 4.1–25.1). Fluoridated
water reduced the gap in oral health between psychiatric patients and the
general population.ConclusionsPsychiatric patients have not shared in the improving oral health of the
general population. Management should include oral health assessment
using standard checklists that can be completed by non-dental personnel.
Interventions include oral hygiene and management of xerostomia.
Mitral valve prolapse and anxiety disorders
Authors: Filho Alaor S. , Maciel Benedito C. , Romano Minna M. D. , Lascala Thiago F. , Trzesniak Clarissa , Freitas-Ferrari Maria C. , Nardi Antonio E. , Martín-Santos Rocío , Zuardi Antonio W. , Crippa José A. S. 
Published: September 2011

SummaryWe investigated whether there is an association between anxiety disorders and mitral valve prolapse. We compared mitral valve prolapse prevalence in individuals with panic disorder (n= 41), social anxiety disorder (n= 89) and in healthy controls (n= 102) in an attempt to overcome the biases of previous studies. Our results show no associations between panic disorder or social anxiety disorder and mitral valve prolapse, regardless of the diagnostic criteria employed, and that the relationship between these conditions seems not to be clinically relevant.
Community treatment orders in England and Wales: national survey of clinicians' views and use
Authors: Manning Catherine , Molodynski Andrew , Rugkåsa Jorun , Dawson John , Burns Tom 
Published: September 2011

Aims and methodTo ascertain the views and experiences of psychiatrists in England and Wales regarding community treatment orders (CTOs). We mailed 1928 questionnaires to members of the Royal College of Psychiatrists.ResultsIn total, 566 usable surveys were returned, providing a 29% response rate. Respondents were generally positive about the introduction of the new powers, more so than in previous UK studies. They reported that their decision-making regarding compulsion was based largely on clinical grounds.Clinical implicationsIn the absence of research evidence or a professional consensus about the use of CTOs, multidisciplinary input in decision-making is essential. Further research and training are urgently needed.
Speaking Memory, Building History
Authors: Levitt Linda 
Published: September 2011

The family member coalition groups that formed in the aftermath of the September 11 attacks have provided more than support and community; their vocal public statements play a significant role in shaping the landscape at the World Trade Center site. In the immediate aftermath, those who lost loved ones came together to share their grief and work toward healing. As the nation tried to make sense of the events, victims' family members had the firsthand experience to articulate the emotional consequences that reverberated broadly. Their emotional authority evolved into a moral one that still complicates decision making at the site.
Victims' family members constitute an ideal profile of what makes news in the media age: they offer narratives that allow the media to craft emotional, dramatic, and personalized stories. A national audience's ready identification with victims' families gives the latter enormous persuasive power. As plans and designs for the site have changed over the years, the influence of victims' families has become undeniable. Their personal perspectives help determine what stories are told, and what stories are excluded, when history is communicated.
Transient Elevation of International Normalized Ratio During Cisplatin-Based Chemotherapy in Patients Who are Taking Warfarin
Authors: Yano Ryoichi , Kurokawa Tetsuji , Tsuyoshi Hideaki , Shinagawa Akiko , Sawamura Yoko , Matsunaga Akiko , Nakamura Toshiaki , Yoshida Yoshio , Yoneda Makoto , Kotsuji Fumikazu , Masada Mikio 
Published: September 2011

Objective: To report 2 cases of a probable interaction between cisplatin and warfarin. Case Summary: Two cases of transient elevation of international normalized ratio (INR) during Irinotecan (60 mg/m2 on days 1, 8, and 15) plus cisplatin (60 mg/m2 on day 1) chemotherapy with concomitant warfarin are presented. In both cases, warfarin dosages were stable at the therapeutic target range prior to initiation of chemotherapy. Granisetron hydrochloride (3 mg on days 1, 6, and 15) and dexamethasone (13.2 mg on day 1 and 6.6 mg on days 2, 3, 8, and 15) were used prior to irinotecan administration in both patients. In addition, aprepitant was administered to both patients for 3–5 days with cisplatin. One of these patients also received aprepitant with irinotecan on days 8 and 15. During chemotherapy, INR was transiently elevated almost 1.5-fold over baseline level on day 3. This variation did not occur in subsequent irinotecan cycles on days 8 and 15. The timing of these increases was similar in each of the cycles. Discussion: Cisplatin was the common drug in the cases presented and therefore could be related to the INR elevations. To our knowledge, these are the first reports of an Interaction between warfarin and irinotecan-cisplatin chemotherapy, but reports of a similar interaction with chemotherapy including platinum derivatives exist. Use of the Horn Drug Interaction Probability Scale indicated a probable interaction between warfarin and cisplatin. Conclusions: Cisplatin might affect the anticoagulation function of warfarin. Careful INR monitoring is necessary during antineoplastic chemotherapy with cisplatin in patients taking warfarin.
Perspectives on Obesity Programs at Children's Hospitals: Insights From Senior Program Administrators
Authors: Eneli Ihuoma , Norwood Victoria , Hampl Sarah , Ferris Michelle , Hibbeln Trillium , Patterson Kellee , Pomietto Maureen , Hassink Sandra 
Published: September 2011

OBJECTIVE:
The obesity epidemic has resulted in an increasing number of children needing multidisciplinary obesity treatment. To meet this need, pediatric obesity programs have arisen, particularly in children's hospitals. In 2008, the National Association of Children's Hospitals and Related Institutions (NACHRI) convened FOCUS on a Fitter Future, a group drawn from NACHRI member institutions, to investigate the needs, barriers, and capacity-building in these programs.

METHODS:
Senior administrators of the 47 NACHRI member hospitals that completed an application to participate in the FOCUS group were invited to complete a Web-based survey. The survey targeted 4 key areas: (1) perceived value of the obesity program; (2) funding mechanisms; (3) administrative challenges; and (4) sustainability of the programs.

RESULTS:
Nearly three-quarters of the respondents reported that their obesity programs were integrated into their hospitals' strategic plans. Obesity programs added value to their institutions because the programs met the needs of patients and families (97%), met the needs of health care providers (91%), prevented future health problems in children (85%), and increased visibility in the community (79%). Lack of reimbursement (82%) and high operating costs (71%) were the most frequently cited challenges. Respondents most frequently identified demonstration of program effectiveness (79%) as a factor that is necessary for ensuring program sustainability.

CONCLUSIONS:
Hospital administrators view tackling childhood obesity as integral to their mission to care for children. Our results serve to inform hospital clinicians and administrators as they develop and implement sustainable pediatric obesity programs.
Biology ofScolytus subscaber(Coleoptera: Curculionidae: Scolytinae) in Grand Fir in Idaho
Authors: Furniss Malcolm M , Kegley Sandra 
Published: September 2011

AbstractWe studied the biology of Scolytus subscaber LeConte (Coleoptera: Curculionidae: Scolytinae) in grand fir, Abies grandis (Douglas) Lindley, in northern Idaho. Presented are new Idaho distribution records, description of the mature larva and adult, biological features, characteristics of infestation and galleries, and natural control factors. The beetle has one generation per year, taking flight in July to infest live branches in the crowns of mature trees. The uniquely shaped egg gallery deeply scores the wood; its two arms curve inward like the Greek letter ε. Eggs are laid along the outer edge of the gallery; hatched larvae mine hidden in the phloem for a short distance after which they mine next to the sapwood where they overwinter. A cerambycid, Tetropium abietis Fall, occurred often in the larger diameter portion of branches infested with S. subscaber. A scolytid, Scolytus abietis Blackman, also infested branches but not those containing S. subscaber. Mortality factors included a braconid parasitoid, Ecphylus arcuatus Muesebeck, on larvae and the flooding of egg galleries with resin evidently caused by defensive response of the host tree to a staining fungus, Spicaria anomala (Corda) Harz., carried by the beetle. In addition, we point out errors and lack of documentation concerning the identity, biology, and behavior of S. subscaber in secondary published sources.
Subterranean Behavior and Other Notes for Ironoquia plattensis (Trichoptera: Limnephilidae) in Nebraska
Authors: Geluso Keith , Harner Mary J , Vivian Lindsay A 
Published: September 2011

Abstract
Ironoquia plattensis Alexander & Whiles (Trichoptera: Limnephilidae) was discovered along the Platte River in central Nebraska in the late 1990s, and basic information about its life history is not well understood. Here, we describe previously undocumented life-history traits that demonstrate strategies used by I. plattensis for surviving in fluctuating wetland environments in a landscape formally shaped by flooding. In an off-channel aquatic habitat along the Platte River, we observed 1) larvae residing in a slough that did not dry completely, 2) larvae emigrating from aquatic to terrestrial habitats 1 mo earlier than reported previously, 3) larvae moving above ground during the summer aestivation period, 4) larvae residing underground in soil during summer aestivation, and 5) mass emergence and swarming of adults after daybreak in autumn. Underground larval aestivation represents a previously undocumented behavior for this species. It is unclear whether aestivating underground represents an unreported common behavior or an infrequent response to local disturbances. At our site, insects may have been responding to a prescribed burn in April and introduction of cattle in mid-May that yielded the site unsuitable for aboveground aestivation. Additional studies on the life history for I. plattensis are warranted to help manage, locate, and protect the few sites where it occurs.
Phylogenetic Relationships of the Tribe Vatellini Based on Larval Morphology, with Description of Derovatellus lentus (Coleoptera: Dytiscidae: Hydroporinae)
Authors: Michat Mariano C , Torres Patricia L M 
Published: September 2011

Abstract
The phylogenetic relationships and putative monophyly of the diving-beetle tribe Vatellini are explored based on a cladistic analysis of 37 taxa and 122 chaetotaxic and morphological characters from larvae. For this purpose, larvae of the genus Derovatellus Sharp are described and illustrated in detail, with particular emphasis on morphometry and chaetotaxy, with the later being unexplored until now. The results strongly support the monophyly of the Vatellini based on several unique larval characters. The terminal insertion of the primary seta UR8 on the second urogomphomere in members of Vatellini represents a reversal from the derived condition. Vatellini was recovered as the sister group of the Australian genus Antiporus Sharp (Hydroporini) based on the presence of: a spatulate nasale, pore PAe and elongate lateral spinulae on prementum. These characters, however, have a reduced value because all of them seem to have evolved several times independently within the Hydroporinae. The tribe Vatellini and its genera are diagnosed and compared with other hydroporine taxa, and interesting features are discussed. Vatellus Aubé is unique within Hydroporinae in the presence of secondary setae on the first antennomere and the first maxillary palpomere, and the one-segmented labial palpus. Derovatellus can be separated from almost every other Hydroporinae by the absence of seta LA1 on prementum and of secondary anterodorsal setae on femur.
Detection and Phylogenetic Analysis of Wolbachia wsp in the Chilo suppressalis (Lepidoptera: Crambidae) in China
Authors: Chai Huan-Na , Du Yu-Zhou 
Published: September 2011

Abstract
Wolbachia are a group of intracellular, inherited endosymbiotic bacteria infecting a wide range of insects that are associated with several different reproductive phenotypes in their hosts. We measured the infection status of Wolbachia in the Asiatic rice borer, Chilo suppressalis (Walker) (Lepidoptera: Crambidae), from 23 locations in China by sequencing the wsp gene. Our results showed that C. suppressalis populations differed widely in their Wolbachia infection rate. Wolbachia was not detected in 13 of the geographically separate populations. In the 10 populations for which infections were detected, the highest rates were ≈40%, in the Guiyang, Xiangyin, Xuzhou, and Yangzhou populations. Phylogenetic analysis of variation in the wsp gene from the six strains of Wolbachia detected showed they belonged to either supergroup A (two populations) or supergroup B (four populations). The phylogenetic relatedness among the wsp sequences found in C. suppressalis was high, and these sequences were also closely related to wsp sequences in other species. This could be an evidence of horizontal transference.
Koss Corporation Case: Trouble in Brew City
Authors: Daugherty Brian , Neely Daniel G. 
Published: September 2011

ABSTRACT
This instructional case provides auditing students an opportunity to examine an interesting real-life embezzlement and financial statement fraud occurring at a publicly traded company in the post-Sarbanes-Oxley (SOX) era. The case focuses on independent auditors' and senior management's reporting responsibilities related to internal control over financial reporting involving smaller public companies (nonaccelerated filers). While all public companies are subject to external auditor and management attestation on the effectiveness of internal control over financial reporting following SOX, the Securities and Exchange Commission (SEC) granted nonaccelerated filers numerous extensions for the effective date of required auditor attestation. In 2010, President Obama signed legislation to permanently exempt nonaccelerated filers from auditor attestation. The case also highlights inherent risk assessments by the independent auditor when one individual holds multiple C-level titles (Chief Executive Officer, Chief Financial Officer, Chief Operating Officer, etc.) within the organization concurrent with membership on the board of directors, and requires students to recommend internal control policies and procedures designed to prevent or detect the embezzlement.
A Series of Revenue Recognition Research Cases Using the Codification
Authors: Alford R. Mark , DiMattia Teresa M. , Hill Nancy T. , Stevens Kevin T. 
Published: September 2011

ABSTRACT
This series of four short cases is designed to help students develop the skills to research the Financial Accounting Standards Board's (FASB) Accounting Standards Codification and other authoritative literature. It also is designed to help improve students' ability to analyze and critique the complex issues that often surround the accounting for revenue recognition. The case scenarios describe transactions in which students must decide whether, when, and how much revenue to recognize. The issues analyzed involve bill-and-hold, multiple-element arrangements, gross versus net revenue reporting, and sales incentives. The cases are also designed to improve teamwork and communication skills. The sequence of cases is intended for use in an intermediate accounting class that covers revenue recognition, or in a capstone class that emphasizes critical thinking and research skills.