bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of photodermatosis in four regions at different altitudes in Yunnan province, China
Authors: DENG Danqi , HANG Yuntao , CHEN Hao , LI Hanying 
Published: September 2010

ABSTRACTIdiopathic photodermatoses are common diseases in dermatology clinics that are associated with ultraviolet (UV) irradiation. The group includes a few dermatoses such as polymorphous light eruption (PLE) and chronic actinic dermatitis (CAD). The prevalence of PLE and CAD in China has not been previously reported. To investigate the population‐based prevalence of polymorphous light eruption (PLE) and chronic actinic dermatitis (CAD) in six minority groups living in four regions with significantly different altitudes in the Yunnan province, a questionnaire survey was administered to 4899 residents of random villages in Yuanjiang county (Dai and Hani minorities), Kunming city (Han people and Yi minority), Lijiang county (Naxi minority), and Shangri‐La county (Zang minority). The altitudes of these counties are 380 m, 1870 m, 2410 m and 3280 m a.s.l., respectively. The results showed that, first, there were 2400 males (49.0%) and 2499 females (51.0%). The prevalence of PLE was 0.65% (32/4899), and the prevalence of CAD was 0.18% (9/4899). PLE was higher among females than males (3.8 vs 1, P < 0.01). The CAD prevalence was not significantly different between males and females (1.6 vs 1, P > 0.05). Second, the prevalence of PLE was increased in higher elevations regions compared to lower elevations (P < 0.01). However, the prevalence of CAD was not significantly different among the four regions (P > 0.05). Third, the mean times of sun exposure for PLE and CAD were 6.0 and 6.5 h/day, respectively. The mean durations of PLE and CAD were 5.8 years, and 6.6 years, respectively. The study demonstrated that the prevalence of PLE is higher than that of CAD in Yunnan, and that the prevalence of PLE is correlated with altitude.
Interactions between epiplakin and intermediate filaments
Authors: WANG Wenqing , SUMIYOSHI Hideaki , YOSHIOKA Hidekatsu , FUJIWARA Sakuhei 
Published: September 2010

ABSTRACTEpiplakin, a cytoskeletal linker protein, was originally identified as an autoantigen in a serum specimen obtained from a patient with subepidermal blistering disease. To examine the binding ability of epiplakin with intermediate filaments (IF), we performed slot‐blot assays using fusion proteins that included various domains and subdomains of epiplakin. At least two of the 4.6 copies in the B domains of epiplakin were necessary for the binding of fusion proteins to keratin. The repeated structures of linker domains also played an important role in the binding of epiplakin to keratin in these assays while also increasing the repeated structure in the linker domain of epiplakin which is involved in the increased binding to IF. A similar but weaker binding to vimentin and desmin was also detected. These observations indicated that the highly repeated structures of epiplakin in both the B and the linker domains, which is the unique feature of this molecule in the plakin family, play an essential role in the functioning of this molecule.
A case of impetigo herpetiformis associated with intrahepatic cholestasis of pregnancy
Authors: FAN Pingshen , GAO Tianwen , LI Miao , LIAO Wenjun , FU Meng , LIU Yufeng , IKEDA Shigaku 
Published: September 2010

ABSTRACTWe herein reported a 26‐year‐old primigravida with impetigo herpetiformis and intrahepatic cholestasis of gestation. She was in gestation for 34 weeks. She had a 5‐month history of pustules on the trunk and limbs that had exacerbated from 1 month before. The jaundice had also emerged lately with increased levels of serous transaminase, bilirubin and bile acid. The histopathology of the lesion confirmed the diagnosis of impetigo herpetiformis. After cesarean section and administration of glucocorticoid, the patient totally recovered.
Pressure cutaneous ulcer over a pacemaker successfully treated with left subcostal transplantation in an extremely thin patient
Authors: HAMADA Manabu , KAYASHIMA Miki , URYU Miki , MOROI Yoichi , URABE Kazunori , FURUE Masutaka 
Published: September 2010

ABSTRACTImplantation of a permanent cardiac pacemaker is becoming common with the increase in the elderly population. A cutaneous ulcer over the pacemaker is a rare complication. Most such cases previously reported demonstrate non‐specific granuloma histologically, negative patch testing of materials used in the device, and no growth in the bacterial culture taken from the generator pocket. To date, the conventional treatments often result in a disap‐pointing outcome. We describe an extremely thin 79‐year‐old Japanese male with a pressure cutaneous ulcer caused by the presence of a pacemaker device. This patient was referred to us with a 1‐month history of repeated cutaneous ulcer and exposure of the cardiac pacemaker in the left pectoral area. Conservative treatment was not effective. Treatment with left subcostal implantation of a new pacemaker, which was not wrapped, and disposition of the electrodes in the subcutaneous tissue of the thorax was successful. Cutaneous manifestations have not recurred for 5 years. Considering the poor condition of the patient, subcostal translocation of the pacemaker was a simple and acceptable treatment for pressure cutaneous ulcer over the pacemaker.
Transcutaneous electrical nerve stimulation offers partial relief in notalgia paresthetica patients with a relevant spinal pathology
Authors: ŞAVK Ekin , ŞAVK Öner , ŞENDUR Faruk 
Published: September 2010

AbstractThere is yet no established mode of curative treatment for notalgia paresthetica (NP). We had previously shown a correlation of NP localization with relevant spinal changes which led us to speculate on the possible role of spinal nerve impingement in the pathogenesis of this entity. Based on these findings we aimed to investigate the possible effect of physical therapy in selected cases of NP. Fifteen NP patients with a relevant spinal pathology (four men and 11 women) were included in the study. The mean age was 52.80 ± 8.83 years (± SD; range, 39–73). NP duration was 8.9 ± 8.13 years (range, 1.5–30). All patients received 10 conventional transcutaneous electrical nerve stimulation (TENS) sessions in the symptomatic area of 20 min duration and high frequency (50–100 Hz). From an initial pruritus score of 10, the mean score by the end of first week was 7.67 ± 2.02 (range, 5–10) and by the end of second week it was 6.80 ± 2.73 (range, 4–11). The differences between the pretreatment and post‐treatment scores were statistically significant. There was no correlation of therapeutic benefit with age or disease duration. We believe that the partial therapeutic benefit of TENS in NP patients is of importance and further research on the effects of various physical therapeutic modalities would be worthwhile.
Successful treatment with cyclosporin administration for persistent benign migratory glossitis
Authors: ABE Masatoshi , SOGABE Yoko , SYUTO Tomoko , ISHIBUCHI Hirohisa , YOKOYAMA Yoko , ISHIKAWA Osamu 
Published: September 2010

ABSTRACTWe herein describe a 54 year‐old female patient with a 5‐year history of persistent and painful benign migratory glossitis (BMG), which was remarkably improved by systemic administration of cyclosporin. She had noted some white patches leaving smooth denuded red areas with whitish elevated borders on the dorsum of her tongue, and finally felt strong pain. The lesion was refractory to the previous treatment with topical corticosteroid treatment for the last 2 years. Because clinicopathological findings were compatible with BMG, systemic administration of 20 mg/day prednisolone and topical 0.1% dexamethasone application were started, however, she suffered a severe relapse after tapering the dosage of predonisolone to 10 mg/day. Because some investigations have suggested that BMG is an oral manifestation of psoriasis, we introduced cyclosporin administration. The systemic treatment of cyclosporin microemulsion pre‐concentrate, 3 mg/kg/day, resulted in a satisfactory improvement. Two months later, we could reduce cyclosporin microemulsion pre‐concentrate dosage to 1.5 mg/kg/day for maintenance therapy, and the disease has been well controlled so far.
Isolated double herpes zoster paresis involving the left facial nerve and the right peroneal nerve following disseminated herpes zoster
Authors: TAKAHAMA Hideto , TSUKAHARA Nanako , HIRAYAMA Masatoshi , ITO Satoshi , SAKURAMOTO Chieko 
Published: September 2010

ABSTRACTA 72‐year‐old Japanese male developed disseminated herpes zoster and could not easily walk due to right drop foot and pain. He soon developed numbness and pain on the left side of his face, and noticed difficulty closing his left eye. The left angle of his mouth drooped. The patient was diagnosed as having a double mononeuropathy (a left facial nerve paresis and a right peroneal nerve paresis) following disseminated herpes zoster. Given that the patient was elderly and had diabetes mellitus, the patient appeared to be an immunocompromised host. We also describe other rare complications of herpes zoster from the published work.
Nodular malignant melanoma with Spitz nevus‐like pathological features finally confirmed by the pathological feature of the sentinel lymph node
Authors: MURAKAMI Masamoto , WADA Takashi , KASHIWAGI Takayuki , ISHIDA‐YAMAMOTO Akemi , IIZUKA Hajime 
Published: September 2010

ABSTRACTThe clinical and histopathological similarities of nodular melanoma and Spitz nevus currently still make a definitive diagnosis difficult. We report here a case of nodular melanoma that was extremely difficult to diagnose both clinically and histopathologically. The primary tumor was a blackish nodule on the scalp and biopsy was performed for pathological diagnosis. Although our first impression was malignant melanoma, we asked two dermatopathologists for second opinions; however, one diagnosed a melanoma and the other a Spitz nevus. Faced with this clinical dilemma, an operation was performed with sentinel node biopsy. Only one sentinel node suggested a metastasis. Histopathological diagnosis to establish whether it was a melanoma metastasis or nodal nevi was also difficult, and we again asked for second opinions from another dermatopathologist in the USA. According to its clinical course and the histopathology of the sentinel lymph node with additional immunohistochemistry, this case was finally diagnosed as a nodular melanoma (T4aN1aM0, stage IIIA). To date, the patient has been given five courses of chemotherapy at 6‐month intervals, with no local recurrence or distant metastases so far.
Sanitary napkin contact dermatitis of the vulva: Location‐dependent differences in skin surface conditions may play a role in negative patch test results
Authors: WAKASHIN Kazuhiro 
Published: September 2010

ABSTRACTI herein report six Japanese female patients with sanitary napkin contact dermatitis of the vulva. This condition may not be uncommon, although only a few reports have been published in Europe and the USA and none from Asia. Routine patch test with a saline‐soaked fragment of their sanitary napkins conducted on the flexor surface of the upper arm gave negative results in all the patients, although pruritic dermatitis was clinically reproducible, developing in a delayed fashion, 2–4 days after the use of any brands of sanitary napkin. Moreover, this dermatitis could be avoided by using a tampon together with wearing cotton shorts. These observations suggest that it is a kind of irritant dermatitis that is induced by the wet local conditions as well as by friction caused by wearing a sanitary napkin rather than that due to sanitary napkin components. Resistance of the skin against external irritant stimuli is variable among different body sites and the genital skin, which is covered by thin stratum corneum, is thought to have low resistance against various external irritating and mechanical stimuli induced by wearing a sanitary napkin. Moreover, it is reasonable to presume that the proliferation of the resident microorganisms of the genital skin that takes place under the wet conditions produced by the use of the napkin also plays a role in the induction of such a unique contact dermatitis. Unfortunately, the commonly employed patch testing method performed on the skin of the upper limb or back cannot simulate the local situation occurring on the vulva under the sanitary napkin. We are urgently in need of a modification in patch testing method that is suited to reproduce similar dermatitis in other body locations.
Coincidental association of mycosis fungoides and occupational systemic sclerosis?
Authors: YASUDA Masahito , AMANO Hiroo , YAMANAKA Masayoshi , TAMURA Atsushi , ISHIKAWA Osamu 
Published: September 2010

ABSTRACTWe report a 58‐year‐old man with mycosis fungoides (MF) and occupational systemic sclerosis (SSc) induced by silica exposure. He was engaged in tunnel construction from the age of 18 to 33 years. He developed MF at the age of 30. Diagnosis of silicosis was made at the age of 52 and SSc at the age of 58. Physical examinations revealed sclerotic skin changes on his forearms and fingers and poikiloderma on the left popliteal fossa and inguinal region. Both antinuclear antibody and antitopoisomerase‐I antibody were positive. We could find no apparent difference between his clinical features and those of idiopathic SSc except for the presence of silicosis and MF. Systemic therapy with interferon‐γ for MF did not improve the skin sclerosis. We discuss the relationship of silica exposure to both MF and SSc.
Giant epidermal cyst extending from sole to dorsum of the foot by penetrating the interosseous muscles
Authors: OZAWA Toshiyuki , HARADA Teruichi , ISHII Masamitsu 
Published: September 2010

ABSTRACTWe present a 65‐year‐old man with a giant epidermal cyst extending from sole to dorsum of the foot by penetrating the interosseous muscles. This epidermal cyst extending from the sole to the dorsum of the foot was big and an extremely rare lesion.
Nodular melanomas: Analysis of the casistic and relationship with thick melanomas and diagnostic delay
Authors: BETTI Roberto , MARTINO Patrizia , VERGANI Raffaella , GUALANDRI Lorenzo , CROSTI Carlo 
Published: September 2010

ABSTRACTThe present study aimed to: (i) define thick melanomas related to nodular melanomas and other melanoma subgroups; and (ii) establish diagnostic delay in relation to the biological behavior of these melanomas and prevention programs. Cutaneous primary melanomas were studied. Nodular melanoma (NM), lentigo maligna melanoma (LMM) and superficial spreading melanoma (SSM) were selected. A further category named vertical growth melanoma (VGM) was also utilized. Analysis for sex, age, different values of thickness (1–2 mm, >2 mm; 1–3 mm, >3 mm; >4 mm), delay to diagnosis and patterns of detection were performed in all of the different subtypes. Eighty‐seven patients with melanomas more than 1 mm of Breslow's thickness out of 506 melanoma were collected. Twenty‐six were nodular cases, 39 SSM, five LMM and 17 VGM. Of those patients with NM, 42% had a thickness of more than 1–2 mm, 34% of 2–4 mm, 23% of more than 4 mm; and 54% with 1–3, 46% with more than 3 mm; and 58% with more than 2 mm. Even considering different values of thickness of more than 1 mm, a delay to diagnosis was significantly lower in NM (4.79 months) than in other subgroups. The value of more than 1 mm of Breslow's thickness may be sufficient to consider a melanoma to be thick. The lower diagnostic delay of NM suggests that they represent faster growing lesions probably with a different biological behavior than other melanoma subtypes. VGM should not be confused with NM, having a longer delay and different clinical features compared with the latter. They represent an area of diagnostic carelessness than potentially be improved.
Scleredema diabeticorum successfully treated with ultraviolet A1 phototherapy
Authors: THUMPIMUKVATANA Narumol , WONGPRAPARUT Chanisada , LIM Henry W. 
Published: September 2010

AbstractScleredema diabeticorum is an uncommon condition. It is one of the cutaneous manifestations in diabetes mellitus that mainly occurs in obese middle‐aged men with insulin‐resistant diabetes. This condition is generally recalcitrant to therapy. Various treatments have been tried with inconsistent results. Here, we describe two cases of scleredema diabeticorum with substantial clinical improvement from a course of medium dose (60 J/cm2) ultraviolet A1 radiation therapy.
Quality versus quantity: acquisition of coping skills following computerized cognitive–behavioral therapy for substance use disorders
Authors: Kiluk Brian D. , Nich Charla , Babuscio Theresa , Carroll Kathleen M. 
Published: September 2010

ABSTRACTAims  To evaluate the changes over time in quality and quantity of coping skills acquired following cognitive behavioral therapy (CBT), and examine potential mediating effects on substance use outcomes.Design  A randomized controlled trial (RCT) evaluating the effectiveness of a computerized version of CBT (CBT4CBT) as an adjunct to standard out‐patient treatment over an 8‐week period.Setting  Data were collected from individuals seeking treatment for substance dependence in an out‐patient community setting.Participants  Fifty‐two substance abusing individuals (50% African American), with an average age of 42 years, and a majority reporting cocaine as their primary drug of choice.Measurements  Participants' responses to behavioral role‐plays of situations associated with high risk for drug and alcohol use were audio‐taped and rated independently to assess their coping responses.Findings  There were statistically significant increases in mean ratings of the quality of participants' coping responses for those assigned to CBT4CBT compared to treatment as usual, and these differences remained significant 3 months after treatment completion. Moreover, quality of coping responses mediated the effect of treatment on participants' duration of abstinence during the follow‐up period.Conclusions  These findings suggest that assignment to the computerized CBT program improved participants' coping skills, as measured by independent ratings of a role‐playing task. It is also the first study to test and support quality of coping skills acquired as a mediator of the effect of CBT for substance use.
Harsh physical punishment as a specific childhood adversity linked to adult drinking consequences: evidence from China
Authors: Cheng Hui G. , Anthony James C. , Huang Yueqin 
Published: September 2010

ABSTRACTAims  The aim of the current study is to estimate the association between childhood physical punishment (CPP) and level of alcohol use disorder (AUD), using two different approaches to take other childhood adversities into account.Design and setting  Population survey using face‐to‐face interviews to a representative sample of non‐institutionalized adult residents of Beijing and Shanghai, China.Participants  A total of 5201 participants aged 18–70 years.Measurements  A version of the World Mental Health Composite International Diagnostic Interview was used. Standardized assessments covered early life experiences of childhood physical punishment, other childhood adversities, parental drinking problems, childhood conduct problems and clinical features of AUD.Findings  A robust association linking CPP and level of AUD was found, holding other childhood adversities constant (probit coefficient = 0.70, 95% CI = 0.40, 1.00) via covariate terms in structural equations modeling. Furthermore, there was evidence that CPP might exert an additional influence on level of AUD over and above a generally noxious family environment (probit coefficient = 0.20, 95% CI = 0.02, 0.38).Conclusions  There appears to be a robust association between reports of harsh punishment in childhood and alcohol dependence in adulthood adjusting for a range of possible confounding factors. Whether the association is causal or whether both are related to a common underlying factor or recall bias needs to be investigated further.
Pathological gambling recovery in the absence of abstinence
Authors: Slutske Wendy S. , Piasecki Thomas M. , Blaszczynski Alex , Martin Nicholas G. 
Published: September 2010

ABSTRACTAims  To examine the role of abstinence from gambling versus controlled gambling in recovery from pathological gambling (PG) in a community‐based survey.Design  Individuals with a life‐time history of PG identified in a community‐based survey were divided into three groups based on their current levels of PG symptoms. These three groups were compared to each other on their past‐year gambling involvement.Setting  National general population twin survey conducted in Australia.Participants  Overall, there were 4764 participants in the community‐based survey (mean age 37.7 years, 57.2% women). Among these were 104 participants with a life‐time history of PG; of the 104 with a life‐time diagnosis of PG, 28 had a past‐year diagnosis of PG, 32 had past‐year problem gambling and 44 had no symptoms of PG in the past year (‘recovery’).Measurements  The measure of PG was based on the NODS (NORC DSM‐IV Screen for Gambling Problems). Past‐year participation in 11 different gambling activities was assessed, as well as the following composite indicators: any gambling, gambling versatility, the number of days and hours spent gambling and the proportion of household income spent on gambling.Findings  Ninety per cent of those in the recovery group participated in some form of gambling in the past year.Conclusions  In this general population survey, nearly all the PG recoveries were achieved in the absence of abstinence. Controlled gambling appears to be a popular road to recovery in the community.
The self‐reported personal wellbeing of a sample of Australian injecting drug users
Authors: Dietze Paul , Stoové Mark , Miller Peter , Kinner Stuart , Bruno Raimondo , Alati Rosa , Burns Lucy 
Published: September 2010

ABSTRACTAims  To examine the self‐reported personal wellbeing of a sample of Australian injecting drug users (IDU) using a standardized instrument and determine the key correlates of variations in self‐reported personal wellbeing.Design, setting and participants  Cross‐sectional survey of 881 Australian IDU.Measurements  Self‐reported personal wellbeing collected using the Personal Wellbeing Index (PWI).Findings  IDU scored significantly lower than the general Australian population on the PWI and all subscales. Lower PWI scores were associated with a range of socio‐demographic, drug use and other health and social characteristics. Across all PWI subscales, lower personal wellbeing scores were associated with unemployment, past 6‐month mental health problems and more frequent injecting (all P < 0.05).Conclusions  The PWI is sufficiently sensitive to distinguish between IDU and the general population, and to identify key correlates of PWI among IDU. Some domains canvassed within the scale, such as health, standard of living and life achievements, are well within the scope of current intervention strategies, such as pharmacotherapy maintenance treatment and housing and employment support services. This suggests that the PWI could be useful in clinical settings by allowing structured identification of the areas of a person's life to be addressed as a part of a treatment regimen. In order to inform targeted prevention and intervention efforts, longitudinal studies of PWI and its correlates among IDU are required.