bluuebunny/crossref_metadata_2025_split huggingface dataset:
Racial Microaggressions and the Filipino American Experience: Recommendations for Counseling and Development
Authors: Nadal Kevin L. , Vigilia Escobar Kara Mia , Prado Gail T. , David E. J. R. , Haynes Kristal 
Published: July 2012

Racial microaggressions are subtle forms of verbal and behavioral discrimination toward people of color. The current qualitative study explores the experiences of Filipino American participants (N= 12), who described 13 categories of microaggressions, including being treated as an alien in one's own land or as a 2nd‐class citizen, being presumed to have inferior status or intellect, being assumed to uphold Filipino stereotypes, or being mistaken for another identity. Recommendations for counseling and development are discussed.Las microagresiones raciales son formas sutiles de discriminación verbal y conductiva hacia las personas de color. El estudio actual cualitativo explora las experiencias de participantes Filipinoamericanos (N= 12), quienes describieron 13 categorías de microagresiones, incluido el ser tratados como extranjeros o como ciudadanos de segunda clase en su propio país, pertenecer presuntamente a una clase social inferior o tener un nivel intelectual inferior, ser presuntamente representantes de estereotipos Filipinos, o ser confundidos con individuos de otra identidad. Se discuten recomendaciones para la consejería y el desarrollo.
Gender Differences in Contextual Predictors of Urban, Early Adolescents' Subjective Well‐Being
Authors: Vera Elizabeth M. , Moallem B. Isabel , Vacek Kimberly R. , Blackmon Sha'kema , Coyle Laura D. , Gomez Kenia L. , Lamp Kristen , Langrehr Kimberly J. , Luginbuhl Paula , Mull Megan K. , Telander Kyle J. , Steele J. Corey 
Published: July 2012

Gender differences in predicting subjective well‐being (SWB) were examined in 168 urban adolescents. School satisfaction predicted life satisfaction for boys; for girls, family satisfaction predicted life satisfaction and neighborhood satisfaction predicted negative affect. Self‐esteem predicted positive affect for both genders, but friends satisfaction and ethnic identity failed to predict SWB.Se examinaron las diferencias de género al predecir el bienestar subjetivo (SWB, por sus siglas en inglés) de 168 adolescentes urbanos. La satisfacción escolar predijo la satisfacción vital en los chicos; en las chicas, la satisfacción familiar predijo la satisfacción vital, y la satisfacción en el vecindario predijo los sentimientos negativos. La autoestima predijo sentimientos positivos en ambos géneros, pero la satisfacción con los amigos y la identidad étnica no fueron predictores del SWB.
Female Effects on Offspring Energetic Status and Consequences on Early Development in Yolk Feeding Brown Trout (Salmo trutta)
Authors: RÉGNIER THOMAS , BOLLIET VALÉRIE , GAUDIN PHILIPPE , LABONNE JACQUES 
Published: July 2012

ABSTRACTEnergetic status can be defined as the interaction between energy stores and metabolic rate. In salmonids, it is variable and influences the timing of emergence, and therefore may have strong effects on both juvenile and maternal fitness. The aim of this study is to (i) describe the ontogeny of energy use for different brown trout clutches to understand how such a variability of energetic status is developed at the end of incubation and (ii) to estimate maternal influences over offspring physiological processes. Using individual measures of total mass and metabolism throughout ontogeny combined with a hierarchicalBayesian modeling approach, we successfully described clutch‐specific (i) metabolic trajectories, (ii) use of yolk resources and the building of new tissues throughout ontogeny. Our results show that females laying large eggs have offspring with lower metabolic costs and higher yolk conversion efficiencies. Females also influence within clutch variance of metabolic and yolk consumption rates leading to potential developmental variations. These results are discussed with regard to their consequences on early life history through the critical period of emergence.J. Exp. Zool. 317A:347–358, 2012. © 2012 Wiley Periodicals, Inc.
Complexation of divalent metal ions with diols in the presence of anion auxiliary ligands: zinc‐induced oxidation of ethylene glycol to glycolaldehyde by consecutive hydride ion and proton shifts
Authors: Ruttink Paul J.A. , Dekker Lennard J.M. , Luider Theo M. , Burgers Peter C. 
Published: July 2012

Ternary complexes of the type AH•••M2+•••L– (AH = diol, including diethylene and triethylene glycol, M = Ca, Mn, Fe, Co, Ni, Cu and Zn and auxiliary anion ligand L– = CH3COO–, HCOO– and Cl–) have been generated in the gas phase by MALDI and ESI, and their dissociation characteristics have been obtained. Use of the auxiliary ligands enables the complexation of AH with the divalent metal ion without AH becoming deprotonated, although A–•••M2+ is often also generated in the ion source or after MS/MS. For M = Ca, dissociation occurs to AH + M2+•••L– and/or to A–•••M2+ + LH, the latter being produced from the H‐shifted isomer A–•••M2+•••LH. For a given ligand L–, the intensity ratio of these processes can be interpreted (barring reverse energy barriers) in terms of the quantity PA(A–) – Caaff(A–), where PA is the proton affinity and Caaff is the calcium ion affinity.Deuterium labeling shows that the complex ion HOCH2CH2OH•••Zn2+•••–OOCCH3, in addition to losing acetic acid (60 Da), also eliminates glycolaldehyde (HOCH2CH=O, also 60 Da); it is proposed that these reactions commence with a hydride ion shift to produce the ion–dipole complex HOCH2CHOH+••• HZnOOCCH3, which then undergoes proton transfer and dissociation to HOCH2CH=O + HZn+•••O = C(OH)CH3. In this reaction, ethylene glycol is oxidized by consecutive hydride ion and proton shifts. A minor process leads to loss of the isomeric species HOCH=CHOH. Copyright © 2012 John Wiley & Sons, Ltd.
Current insights on the regenerative potential of the periosteum: Molecular, cellular, and endogenous engineering approaches
Authors: Colnot Céline , Zhang Xinping , Tate Melissa L. Knothe 
Published: July 2012

AbstractWhile century old clinical reports document the periosteum's remarkable regenerative capacity, only in the past decade have scientists undertaken mechanistic investigations of its regenerative potential. At a Workshop at the 2012 Annual Meeting of Orthopaedic Research Society, we reviewed the molecular, cellular, and tissue scale approaches to elucidate the mechanisms underlying the periosteum's regenerative potential as well as translational therapies engineering solutions inspired by its remarkable regenerative capacity. The entire population of osteoblasts within periosteum, and at endosteal and trabecular bone surfaces within the bone marrow, derives from the embryonic perichondrium. Periosteal cells contribute more to cartilage and bone formation within the callus during fracture healing than do cells of the bone marrow or endosteum, which do not migrate out of the marrow compartment. Furthermore, a current healing paradigm regards the activation, expansion, and differentiation of periosteal stem/progenitor cells as an essential step in building a template for subsequent neovascularization, bone formation, and remodeling. The periosteum comprises a complex, composite structure, providing a niche for pluripotent cells and a repository for molecular factors that modulate cell behavior. The periosteum's advanced, “smart” material properties change depending on the mechanical, chemical, and biological state of the tissue. Understanding periosteum development, progenitor cell‐driven initiation of periosteum's endogenous tissue building capacity, and the complex structure–function relationships of periosteum as an advanced material are important for harnessing and engineering ersatz materials to mimic the periosteum's remarkable regenerative capacity. © 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 30:1869–1878, 2012
Development of a disease‐specific quality‐of‐life questionnaire for anterior and central skull base pathology—The skull base inventory
Authors: de Almeida John R. , Vescan Allan D. , Gullane Patrick J. , Gentili Fred , Lee John M. , Lohfeld Lynne , Ringash Jolie , Thoma Achilles , Witterick Ian J. 
Published: July 2012

AbstractObjectives/Hypothesis:Anterior and central skull base lesions and their surgical treatment (endoscopic or open approaches) can affect quality of life. A disease‐specific instrument is needed to compare quality of life for different surgical approaches.Study Design:Items were generated using a composite strategy consisting of chart review, systematic review of skull base instruments, expert interviews, and qualitative analysis of patient focus groups. A cross‐sectional survey study was performed to reduce items based on an item impact score.Methods:Charts of 138 patients who underwent skull base surgery were reviewed to identify physical items and domains. Five experts were interviewed for item and domain identification. Thirty‐four patients were recruited into eight focus groups based on their surgical approach (open or endoscopic) and tumor location (anterior or central). Items were generated using a composite approach and then reduced into a final questionnaire using item impact scores.Results:Chart review identified 47 physical items. Systematic review revealed nine relevant instruments with 217 relevant items. Experts identified 11 domains with 69 additional items. Qualitative analysis of focus groups generated 49 items. A total of 382 items were identified and reduced to 77 items after eliminating overlapping and irrelevant items. Further item reduction using item impact scores yielded 41 items.Conclusions:The Skull Base Inventory is a disease‐specific quality‐of‐life instrument. Psychometric properties have yet to be tested. It may serve to compare quality of life for endoscopic or open procedures. Laryngoscope, 2012
Multi‐institutional evaluation of a sinus surgery checklist
Authors: Soler Zachary M. , Poetker David A. , Rudmik Luke , Psaltis Alkis J. , Clinger John D. , Mace Jess C. , Smith Timothy L. 
Published: July 2012

AbstractObjectives/Hypothesis:To examine the frequency of safe surgical practices specific to endoscopic sinus surgery (ESS) before and after implementation of a checklist at four institutions across North America.Study Design:Prospective, multi‐institutional, observational study.Methods:Consecutive surgeries were observed at four institutions before (n = 100) and after (n = 100) implementation of the ESS Checklist. A passive observer documented whether 10 specific tasks were performed by the surgical team during the course of each case. The frequency with which each item was performed was tabulated, and differences across institutions were evaluated using the Pearson χ2 test. Improvement in the frequency of each single item between pre‐ and postintervention time periods was assessed by the McNemar χ2 test.Results:Successful performance of all 10 tasks in the prechecklist period was not observed for any ESS case at any of the four study sites. As might be expected, performance of any individual task was highly variable, ranging from 14% to 95%. After implementation of the ESS Checklist, successful performance of all 10 tasks during an individual surgery increased from 0% to 87% across all institutions, a change that was highly significant (P < .001). Significant increases in the performance of individual tasks was observed for nine of 10 items across all institutions (P ≤ .031 for all).Conclusions:Significant heterogeneity exists with regard to performance of specific tasks aimed at minimizing error during ESS. Utilization of the ESS Checklist standardized practice across four institutions and significantly increased the likelihood that individual safety tasks were performed during the course of sinus surgery. Laryngoscope, 2012
Prognostic factors in sinonasal sarcomas: Analysis of the surveillance, epidemiology and end result database
Authors: Wu Arthur W. , Suh Jeffery D. , Metson Ralph , Wang Marilene B. 
Published: July 2012

AbstractObjectives/Hypothesis:Sinonasal sarcomas are rare and often aggressive malignant tumors. Although tumor histology and location are the only reported prognostic indicators for this disease, we sought to determine if additional clinical factors might influence patient survival.Study Design:Retrospective cohort study using a national cancer database.Methods:Cases of sinonasal sarcomas from 1973 to 2008 were extracted from the Surveillance, Epidemiology and End Result (SEER) database. The influence of patient age, gender, race, and prior irradiation, as well as tumor histology and subsite, was calculated using the Kaplan‐Meier method.Results:A total of 352 patients with sinonasal sarcomas were identified. Histologic subtype, tumor location, gender, and patient age were found to influence patient survival. Specifically, increased age, male sex, frontal and maxillary sinus subsites, and rhabdomyosarcoma and Kaposi sarcoma histologies were associated with a significant increase in mortality rate (P < .05).Conclusions:This study comprises the largest analysis of patients with sinonasal sarcoma in the literature and demonstrates the impact of patient age, tumor histology, and tumor location on the overall survival of individuals with these rare malignancies. Laryngoscope, 2012
Trends in the use of smokeless tobacco in united states, 2000–2010
Authors: Bhattacharyya Neil 
Published: July 2012

AbstractObjectives/Hypothesis:To quantify trends in the use of smokeless tobacco in the United States.Study Design:Longitudinal analysis of national population database.Methods:The National Health Interview Surveys for 2000, 2005, and 2010 were analyzed for adult responses to specific questions regarding smokeless tobacco use, which includes chewing tobacco and snuff. Smokeless tobacco lifetime exposure, current use, and frequency of use were determined according to each sampled year, examining for trends over the past decade. Subset analysis for young adults (ages 18–44 years) was conducted. Demographic factors associated with smokeless tobacco use were also determined.Results:A total of 86,270 adults were surveyed. Among all adults, the proportions of those who had ever tried chewing tobacco were 7.1 ± 0.2%, 8.5 ± 0.2%, and 9.2 ± 0.2% for 2000, 2005, and 2010, respectively (P < .001). Similarly, the proportions of those who had ever tried snuff were 4.4 ± 0.2%, 7.5 ± 0.2%, and 8.4 ± 0.3%, respectively (P < .001). In aggregate, the proportions who were regular users of chewing tobacco remained stable over the survey years: 1.3 ± 0.1%, 1.1 ± 0.1%, and 1.2 ± 0.1%, respectively (P = .382). In contrast, the percentages who were regular users of snuff tobacco increased significantly over the survey years: 1.4 ± 0.1%, 1.6 ± 0.1%, and 2.0 ± 0.1% (P < .001). The proportion of young adults regularly using snuff rose to 2.8 ± 0.2% (P < .001) in 2010. Male sex, non‐Hispanic ethnicity, white race, and less than a high school education were characteristics that were strongly associated with smokeless tobacco use.Conclusions:There was a trend toward increased smokeless tobacco use, mainly snuff, in the United States in the past decade. This trend was more prominent among young adults and likely will have future health‐care implications. Laryngoscope, 2012
Growth envelopes of Besov spaces on fractalh‐sets
Authors: Caetano António M. 
Published: July 2012

AbstractUnder appropriate conditions, we determine the growth envelopes of Besov spaces on so‐calledh‐sets. In the way we clarify what should in general be meant by such Besov spaces and establish some elementary embeddings. Actually, we are even able to give an optimal necessary condition for one of such embeddings as a by‐product of the proof of the growth envelope result.
The food contaminant and nephrotoxin ochratoxin A enhances Wnt1 inducible signaling protein 1 and tumor necrosis factor‐α expression in human primary proximal tubule cells
Authors: Hennemeier Isabell , Humpf Hans‐Ulrich , Gekle Michael , Schwerdt Gerald 
Published: July 2012

ScopeThe underlying molecular mechanisms of nanomolar ochratoxin A (OTA) concentrations, especially those on pathophysiological relevant gene expression in target tissue and underlying signaling mechanisms are unknown.Methods and resultsqPCR arrays showed that 14 days exposure of human primary proximal tubule cells to 10 nM OTA influences the expression of genes that are related to inflammation, malignant transformation, and epithelial‐to‐mesenchymal transition. Wnt1 inducible signaling protein 1 (WISP1), an oncogenic, and profibrotic growth factor, turned out to be the gene with the strongest upregulation. Its expression, and that of TNF‐α, an important inflammatory mediator, was further investigated in human renal cells and in primary human lung fibroblasts. OTA‐induced upregulation of WISP1 and TNF‐α occurs only in renal cells. Inhibition of ERK1/2 activation reverses the effect of OTA on WISP1 and TNF‐α expression. Wnt or other signaling pathways were not involved. Upregulation of WISP1 and TNF‐α occured independently of each other.ConclusionLong‐term exposure of human kidney cells with OTA concentrations expectable in renal tissue due to average dietary intake leads in an ERK1/2‐dependent manner to pathogenetic alterations of gene expression, notably WISP1 and TNF‐α. Renal long‐term risk by OTA is actually not excludable and argues for low but rational safety levels.
Chromosomal aberrations, Yq microdeletion, and sperm DNA fragmentation in infertile men opting for assisted reproduction
Authors: Shamsi Monis B. , Kumar Rajeev , Malhotra Neena , Singh Nita , Mittal Suneeta , Upadhyay Ashish D. , Dada Rima 
Published: July 2012

AbstractMale infertility is a multi‐factorial disorder, and identification of its etiology in an individual is critical for treatment. Systematically elucidating the underlying genetic causes (chromosomal and Yq microdeletion) and factors, such as reactive oxygen species (ROS) levels and total antioxidant capacity (TAC), which contribute to sperm DNA damage, may help to reduce the number of men with idiopathic infertility and provide them with the most suitable therapeutics and counseling. This study was done to comprehensively investigate genetic and oxidative stress factors that might be the etiology of a large percentage of men with idiopathic infertility. One hundred twelve infertile men and 76 fertile controls were screened for chromosomal aberrations and Yq microdeletions. ROS, TAC, and sperm DNA damage were assessed in cytogenetically normal, non‐azoospermic men with intact Y chromosome (n = 93). ROS was assessed in neat and washed semen by chemiluminescence; seminal TAC with a commercially available kit; and sperm DNA damage by the comet assay. Two men had cytogenetic abnormalities and seven men harbored Yq microdeletions. ROS levels in neat and washed semen of infertile men were significantly higher (P < 0.01) than controls. Infertile men had significantly lower (P < 0.01) TAC levels (1.79 mM), whereas sperm DNA fragmentation in infertile men was significantly higher (P < 0.01) than controls. Genetic factors and oxidative stress cumulatively account for large number of idiopathic infertile cases. Unlike, genetic causes, which cannot be cured, timely identification and management of oxidative stress may help to reverse/reduce the effects on induced DNA damage, and improve the outcomes for infertile males. Mol. Reprod. Dev. 79: 637–650, 2012. © 2012 Wiley Periodicals, Inc.
Chemical and biochemical approaches in the study of histone methylation and demethylation
Authors: Li Keqin Kathy , Luo Cheng , Wang Dongxia , Jiang Hualiang , Zheng Y. George 
Published: July 2012

AbstractHistone methylation represents one of the most critical epigenetic events in DNA function regulation in eukaryotic organisms. Classic molecular biology and genetics tools provide significant knowledge about mechanisms and physiological roles of histone methyltransferases and demethylases in various cellular processes. In addition to this stream line, development and application of chemistry and chemistry‐related techniques are increasingly involved in biological study, and offer information otherwise difficult to obtain by standard molecular biology methods. Herein, we review recent achievements and progress in developing and applying chemical and biochemical approaches in the study of histone methylation, including chromatin immunoprecipitation, chemical ligation, mass spectrometry, biochemical methylation and demethylation assays, and inhibitor development. These technological advances allow histone methylation to be studied from genome‐wide level to molecular and atomic levels. With ChIP technology, information can be obtained about precise mapping of histone methylation patterns at specific promoters, genes, or other genomic regions. MS is particularly useful in detecting and analyzing methylation marks in histone and nonhistone protein substrates. Chemical approaches that permit site‐specific incorporation of methyl groups into histone proteins greatly facilitate the investigation of biological impacts of methylation at individual modification sites. Discovery and design of selective organic inhibitors of histone methyltransferases and demethylases provide chemical probes to interrogate methylation‐mediated cellular pathways. Overall, these chemistry‐related technological advances have greatly improved our understanding of the biological functions of histone methylation in normal physiology and diseased states, and also are of great potential to translate basic epigenetics research into diagnostic and therapeutic applications in the clinic. © 2010 Wiley Periodicals, Inc. Med Res Rev., 32, No. 4, 815‐867, 2012
Desiccation shrinkage of non‐clayey soils: a numerical study
Authors: Hu Liang Bo , Péron Hervé , Hueckel Tomasz , Laloui Lyesse 
Published: July 2012

SUMMARYA mesoscale model of desiccation of soil based on the evolution of the pore system idealized as bimodal is numerically examined. A simplified evolution of the model reveals a series of characteristics that qualitatively agree with the observed macroscopic experimental findings. The principal mechanism is deemed to be driven by the surface evaporation and water outflow generating a pore pressure gradient resulting in the shrinkage mainly of the largest pores. The amount of shrinkage is a function of (negative) pore pressure and is controlled by the compressibility of the solid matrix. The numerical model includes also the ensuing partial saturation stage initiated by the air entry simulated as a scenario with a moving phase interface inside the pore. The proposed model can be extended beyond the two‐mode porosity soils, to include the multi‐modal porosity, or its statistical representation.Copyright © 2012 John Wiley & Sons, Ltd.
Priority queue with customer upgrades
Authors: He Qi‐Ming , Xie Jingui , Zhao Xiaobo 
Published: July 2012

AbstractThis article is concerned with a general multi‐class multi‐server priority queueing system with customer priority upgrades. The queueing system has various applications in inventory control, call centers operations, and health care management. Through a novel design of Lyapunov functions, and using matrix‐analytic methods, sufficient conditions for the queueing system to be stable or instable are obtained. Bounds on the queue length process are obtained by a sample path method, with the help of an auxiliary queueing system. © 2012 Wiley Periodicals, Inc. Naval Research Logistics, 2012