bluuebunny/crossref_metadata_2025_split huggingface dataset:
The cell surface glycoprotein CDCP1 in cancer—Insights, opportunities, and challenges
Authors: Wortmann Andreas , He Yaowu , Deryugina Elena I. , Quigley James P. , Hooper John D. 
Published: June 2009

AbstractIn the last few years dysregulated expression of the cell surface glycoprotein CUB domain‐containing protein 1 (CDCP1) has been associated with several cancers and this cell surface molecule has been recognized both as a tumor marker and as a potential target to disrupt progression of cancer. Here we summarize what is known about CDCP1 including its structural features, expression in normal and cancerous tissues, and the in vitro experiments and studies in animal models that have provided the key insights into its potential role in tumor formation and metastasis in humans. We conclude by highlighting opportunities and challenges in targeting CDCP1 in cancer. © 2009 IUBMB IUBMB Life 61(7): 723–730, 2009
Giving off mixed signals—Distinct functions of α5β1 and αvβ3 integrins in regulating cell behaviour
Authors: Morgan Mark R. , Byron Adam , Humphries Martin J. , Bass Mark D. 
Published: June 2009

AbstractThe formation, maturation, and dissolution of focal adhesions are basic prerequisites of cell migration and rely on the recruitment, signalling, and endocytosis of integrins. In many instances, extracellular matrix molecules are recognised by a number of integrins, and it is the sequential involvement of different integrins that allows establishment of cell polarity and migration towards a matrix stimulus. In this review, we consider both the similarities and differences between two key fibronectin receptors, αvβ3 and α5β1 integrin. By considering the GTPase and kinase signalling and trafficking of two such closely‐related receptors, we begin to understand how cell migration is coordinated. © 2009 IUBMB IUBMB Life 61(7): 731–738, 2009
Clinical grade preparation of human natural regulatory T‐cells encoding the thymidine kinase suicide gene as a safety gene: authors' reponse
Authors: Guillot‐Delost Maude , Cheraï Mustapha , Hamel Yamina , Rosenzwajg Michelle , Baillou Claude , Simonin Ghislaine , Leclercq Virginie , Mariotti‐Ferrandiz Maria Encarnita , Six Adrien , Bon‐Durand Véronique , Maury Sébastien , Salomon Benoit L. , Cohen José L. , Klatzmann David , Lemoine François M. 
Published: June 2009

AbstractThis Response refers to JGM 1286, which was published in The Journal of Gene Medicine 11:2. Please follow the link below to view the Letter to the Editor.Letter to the Editor
Systematically improving physician assignment during in‐hospital transitions of care by enhancing a preexisting hospital electronic health record
Authors: Zsenits Balazs , Polashenski Walter A. , Sterns Richard H. , Brown David R. , Moheet Amir 
Published: June 2009

AbstractBACKGROUND:The nationwide expansion of the hospitalist movement brings rapid change in communication and work processes in many hospitals. While our fast‐growing hospitalist program has greatly improved length of stay and quality measures, it has also faced complex operational challenges affecting the whole organization rather than just our division: assigning and tracking hospitalist coverage of admitted patients was one of these challenges.METHODS:We integrated a system of algorithms and interface solutions into our hospital's preexisting electronic health records (EHR) program to act as a decision support tool and computerized safety net during admission and patient distribution. Its main structural elements include: (1) algorithms that identify patients for hospitalist coverage and monitor coverage during transitions of care; (2) EHR data fields that enable hospitalists to assign and update each patient's coverage information in real time; and (3) a combination of display solutions to inform users of coverage arrangements and alert for potentially misassigned patients. Our system assists with correct attending selection on admission. It also assures continuity of coverage during transitions within the hospitalist program and across care settings.RESULTS:Our enhancements to the EHR received unanimously positive assessment by users and added an important layer of patient safety and organizational efficiency for our hospitalist program.DISCUSSION:Adaptations of our tools may provide similar opportunities for improvements in a variety of hospitalist settings; an integrated computerized physician order entry (CPOE) system is not a prerequisite. We demonstrate how the presented innovations can be used to enhance other EHR functions as well. Journal of Hospital Medicine 2009;4:308–312. © 2009 Society of Hospital Medicine.
How complete is the evidence for thromboembolism prophylaxis in general medicine patients? A meta‐analysis of randomized controlled trials
Authors: Bump Gregory M. , Dandu Madhavi , Kaufman Samuel R. , Shojania Kaveh G. , Flanders Scott A. 
Published: June 2009

AbstractOBJECTIVES:Guidelines recommend pharmacologic prophylaxis for hospitalized medical patients at increased risk of thromboembolism. Despite recommendations, multiple studies demonstrate underutilization. Factors contributing to underutilization include uncertainty that prophylaxis reduces clinically relevant events, as well as questions about the best form of prophylaxis. We sought to determine whether prophylaxis decreases clinically significant events and to answer whether unfractionated heparin (UFH) or low molecular weight heparin (LMWH) is either more effective or safer.DATA SOURCES:The MEDLINE, EMBASE, CINAHL, and Cochrane databases were searched through June 2008. Relevant bibliographies and conference proceedings were reviewed and LMWH manufacturers were contacted.STUDY SELECTION:Randomized trials comparing UFH or LMWH to control, as well as head‐to‐head comparisons of UFH to LMWH in general medicine patients.DATA EXTRACTION AND ANALYSIS:End points of deep venous thrombosis (DVT), proximal or symptomatic DVT, pulmonary embolism, mortality, bleeding, and thrombocytopenia were extracted from individual trials. Pooled relative risks were calculated using random effects modeling.RESULTS:We identified 8 trials comparing prophylaxis to control, and 6 trials comparing UFH to LMWH. Prophylaxis reduced DVT (relative risk [RR] = 0.55; 95% confidence interval [CI]: 0.36‐0.92), proximal DVT (RR = 0.46; 95% CI: 0.31‐0.69), and pulmonary embolism (RR = 0.70; 95% CI: 0.53‐0.93). Prophylaxis increased the risk of any bleeding (RR = 1.54; 95% CI: 1.15‐2.06) but not major bleeding. Across trials comparing LMWH to UFH, there were no differences for any outcome.CONCLUSIONS:Among medical patients, pharmacologic prophylaxis reduced the risk of thromboembolism without increasing risk of major bleeding. The current literature does not demonstrate superior efficacy of UFH or LMWH. Journal of Hospital Medicine 2009;4:289–297. © 2009 Society of Hospital Medicine.
The practicalities of a Learning Tourism Destination: a case study of the Ningaloo Coast
Authors: Schianetz Karin , Jones Tod , Kavanagh Lydia , Walker Paul A. , Lockington David , Wood David 
Published: June 2009

AbstractThe complex and dynamic nature of tourism, and the need to address triple bottom line sustainability, has encouraged a search for adaptive tourism management approaches based on organisational learning. In this paper, the authors discuss a practical approach for the implementation of a Learning Tourism Destination (LTD), a new concept derived from the theory of learning organisations. Preliminary results from a case study undertaken at the Ningaloo Coast in Western Australia are discussed. The conducted surveys indicate that the LTD forms a useful framework for fostering consensus building, dialogue and collective learning processes among stakeholders. The proposed approach has the potential to improve decision‐making within the concept of sustainable tourism development by facilitating participative planning processes. The overall strategy of this paper is to explore the practicalities of the LTD implementation process, and to spark further conceptual and practical debate, based on the analysis of the Ningaloo case study. Copyright © 2009 John Wiley & Sons, Ltd.
How to repair customer trust after negative publicity: The roles of competence, integrity, benevolence, and forgiveness
Authors: Xie Yi , Peng Siqing 
Published: June 2009

AbstractThe purpose of the comprehensive model presented here is to explain the underlying mechanism by which corporations can repair customer trust after negative publicity. The study sets out to examine corporate informational, affective, and functional initiatives managers take to influence three trustworthiness factors—competence, benevolence, and integrity—and to elicit forgiveness. A scenario‐based experiment conducted to test the conceptual model found support for most hypotheses. According to the results, rebuilding a trustworthy image and earning consumer forgiveness are crucial steps in repairing consumer trust. A clear pattern of influential factors for different trustworthiness aspects was found, indicating that affective initiatives are the most effective strategy in shaping a corporate image of integrity and benevolence, and that providing sufficient information is a key activity for enhancing consumers' judgment about the firm's competence. © 2009 Wiley Periodicals, Inc.
Do VIP programs always work well? The moderating role of loyalty
Authors: Kim Donghoon , Lee Seung‐yon , Bu Kyunghee , Lee Seho 
Published: June 2009

AbstractThis paper addresses some important issues involving the effective deployment of ever‐increasing VIP program budgets. Recent research results on the effects of VIP programs have been somewhat mixed. Some studies have found a positive influence on consumer behavior, while others report no significant impact. The purpose of this research is to provide a possible explanation for such contradictory evidence in the literature. The results of this study reveal that customer responses to VIP programs depend on their loyalty traits. Specifically, two loyalty dimensions—behavioral loyalty and attitudinal loyalty—interact with each other in moderating the impact of VIP programs on customer response. A VIP program may produce positive results even for customers who are low in behavioral loyalty, with low spending levels, if their attitudinal loyalty is high. Conversely, such a program may not produce significant results even for high‐spending customers if their attitudinal loyalty is not high enough. Thus, analysis that overlooks the moderating role of loyalty dimensions may have led to erroneous conclusions. Finally, at the managerial level, this paper points out the potential problems of relying solely on behavioral loyalty measures, such as purchase amount, in identifying VIP customers. © 2009 Wiley Periodicals, Inc.
The investigation of Chinese consumer values, consumption values, life satisfaction, and consumption behaviors
Authors: Xiao Ge , Kim Jai‐Ok 
Published: June 2009

AbstractThe primary objective of this study was to investigate how the changing value systems of modern Chinese consumers affect their consumption behaviors and life satisfaction through the mediating variables of consumption values. The results of the multivariate data analysis show that three out of four types of consumer values (i.e., functional, emotional, and social) were positively related to foreign brand purchasing. Among all accepted relationships, the one between collectivism and functional value was the highest, whereas the collectivism and epistemic value relationship was the lowest. Individualism and collectivism were both found to be positively related to foreign brand purchasing and life satisfaction. Compared to collectivists, individualists were less satisfied with their current lives, but they held a more favorable attitude toward foreign brands. © 2009 Wiley Periodicals, Inc.
Value‐based segmentation of luxury consumption behavior
Authors: Wiedmann Klaus‐Peter , Hennigs Nadine , Siebels Astrid 
Published: June 2009

AbstractFollowing a broader perspective in exploring customer perceptions of and motives for purchasing luxury brands, it is not sufficient to explain the whole picture of luxury consumption in terms of socially oriented consumer motives and the desire to impress others. The main contribution here is to explore a multidimensional framework of luxury value as a general basis for identifying value‐based consumer segments. The empirical results can be seen as a first step toward a better understanding of consumers' luxury value perceptions as based on social, individual, functional, and financial aspects. ©2009 Wiley Periodicals, Inc.
MIBG scintigraphy for differentiating Parkinson's disease with autonomic dysfunction from Parkinsonism‐predominant multiple system atrophy
Authors: Chung Eun Joo , Lee Won Yong , Yoon Won Tae , Kim Byeong Joon , Lee Gyeong Han 
Published: June 2009

AbstractParkinson's disease (PD) with autonomic dysfunction is difficult to differentiate from Parkinsonism‐predominant multiple system atrophy (MSA‐p). This study aimed to analyze the validity of MIBG scintigraphy for PD with autonomic dysfunction and MSA‐p. Thirty‐nine patients (PD: 27 patients, MSA‐p type: 12) and 12 age‐matched controls were prospectively enrolled and underwent MIBG scintigraphy and autonomic function test (AFT). We separately calculated early and delayed heart‐to‐mediastinal (H/M) ratio and washout rates (WRs). AFT was composed of sympathetic skin reflex and parasympathetic tests based on heart rate variability. Abnormal AFT was observed in 17 (63%) of PD and 10 (83%) of MSA‐p. On comparing PD with abnormal AFT with MSA‐p, either the early or delayed H/M ratio in PD was not different from that in MSA‐p (P > 0.05). Only the WR could differentiate PD with abnormal AFT from MSA‐p (47.07 ± 57.48 vs. 31.39 ± 31.52, respectively) (P = 0.026). According to the results, WR may be more useful than the early and delayed H/M ratio to distinguish MSA‐p from PD with abnormal AFT. Furthermore, the MIBG uptake did not reflect the disease duration or severity. © 2009 Movement Disorder Society
Online process mean estimation usingL1norm exponential smoothing
Authors: Jiang Wei , Zhu Yongzhong 
Published: June 2009

AbstractA basic assumption in process mean estimation is that all process data are clean. However, many sensor system measurements are often corrupted with outliers. Outliers are observations that do not follow the statistical distribution of the bulk of the data and consequently may lead to erroneous results with respect to statistical analysis and process control. Robust estimators of the current process mean are crucial to outlier detection, data cleaning, process monitoring, and other process features. This article proposes an outlier‐resistant mean estimator based on theL1norm exponential smoothing (L1‐ES) method. TheL1‐ES statistic is essentially model‐free and demonstrably superior to existing estimators. It has the following advantages: (1) it captures process dynamics (e.g., autocorrelation), (2) it is resistant to outliers, and (3) it is easy to implement. © 2009 Wiley Periodicals, Inc. Naval Research Logistics 2009
Policy incentives and the extension of mortgage credit: Increasing market discipline for subprime lending
Authors: An Xudong , Bostic Raphael W. 
Published: June 2009

AbstractThe lax underwriting in non‐prime mortgage markets is widely perceived as one cause of the recent difficulties in the housing market. Policymakers are currently considering moves such as enforcing more careful underwriting to provide additional discipline to mortgage markets. This research explores the possibility of another approach to supplement or replace some of these efforts, namely the use of policy to create incentives for Fannie Mae and Freddie Mac (together, the GSEs) to help “check” behavior in non‐prime markets. The hypothesis is that the GSE Act affordable housing goals have increased GSE focus on targeted loan purchases, which in turn has led prime market lenders to compete more aggressively for borrowers on the margin between prime and subprime credit quality. As a consequence, these marginal borrowers will be more inclined to take prime mortgages rather than higher‐cost subprime loans. We test this hypothesis and find empirical support for it. We observe a negative relationship between the growth in GSE market share and the growth in subprime market share over time, and find that the impact of the GSEs on subprime lending tends to be stronger in high‐minority neighborhoods, where subprime lending has been concentrated and growing the fastest. Simulations show that a 10 percent increase in GSE market share (for example, from 20 to 22 percent) can cause 45,000 borrowers using prime instead of subprime loans a cost savings of about $1.7 billion. These results suggest that the GSEs, regardless of their postconservatorship form, should continue to devote attention to serving underserved populations and suggest that significant welfare benefits will accrue. © 2009 by the Association for Public Policy Analysis and Management.
Harming the best: How schools affect the black‐white achievement gap
Authors: Hanushek Eric A. , Rivkin Steven G. 
Published: June 2009

AbstractSizeable achievement differences by race appear in early grades, but substantial uncertainty exists about the impact of school quality on the black‐white achievement gap and particularly about its evolution across different parts of the achievement distribution. Texas administrative data show that the overall growth in the achievement gap between third and eighth grades is larger for students with higher initial achievement and that specific teacher and peer characteristics explain a substantial share of the widening. The adverse effect of attending school with a high black enrollment share appears to be an important contributor to the larger growth in the achievement differential in the upper part of the test score distribution. This evidence reaffirms the major role played by peers and school quality, but also presents a policy dilemma. Teacher labor market complications, current housing patterns, legal limits to desegregation efforts, and uncertainty about the overall effects of specific desegregation programs indicate that effective policy responses will almost certainly involve a set of school improvements beyond simple changes in peer racial composition and the teacher experience distribution. © 2009 by the Association for Public Policy Analysis and Management.
A better budget rule
Authors: Dothan Michael , Thompson Fred 
Published: June 2009

AbstractDebt limits, interest coverage ratios, one‐off balanced budget requirements, pay‐as‐you‐go rules, and tax and expenditure limits are among the most important fiscal rules for constraining intertemporal transfers. There is considerable evidence that the least costly and most effective of such rules are those that focus directly on the rate of spending growth, even with their seemingly ad hoc nature and possibilities for circumvention. In this paper, we use optimal control theory and martingale methods to justify a transparent, nonarbitrary rule governing maximum sustainable rate of spending growth, treating the revenue structure of a jurisdiction as a given continuous‐time stochastic process. Our results can be used to determine whether a proposed rate of spending growth is sustainable or not. © 2009 by the Association for Public Policy Analysis and Management
NSF's Experimental Program to Stimulate Competitive Research (EPSCoR): Subsidizing academic research or state budgets?
Authors: Wu Yonghong 
Published: June 2009

AbstractThis cross‐state empirical study focuses on the National Science Foundation's (NSF) Experimental Program to Stimulate Competitive Research (EPSCoR) and examines its impact on the academic research and development (R&D) expenditures financed by state governments. Based on a panel of 50 states during 1979–2006, the empirical results indicate that EPSCoR, while increasing federal R&D support to EPSCoR states, crowded out financial support for academic research from the governments of EPSCoR states. About one‐third of EPSCoR funds went to subsidize state budgets. The crowd‐out effect calls for some reconsideration of EPSCoR program design in order to maintain or even increase the state government financial support for academic research activities deemed critical to academic competitiveness and economic prospects. © 2009 by the Association for Public Policy Analysis and Management.
School reintegration for children and adolescents with cancer: The role of school psychologists
Authors: Harris Mekel S. 
Published: June 2009

AbstractAs a result of advancements in medical expertise and technology, children and adolescents diagnosed with cancer now have opportunities to participate in many typical activities, including school. To some extent, school reintegration reflects positive adjustment to their illness. Nevertheless, children and adolescents with cancer may experience consequences that result in problems with school functioning and performance, along with other psychosocial difficulties. Accordingly, school personnel may not be equipped to appropriately intervene with this unique population of students. One means of offsetting such consequences, and thus facilitating successful school reintegration, is consultation between children or adolescents, parents and/or caregivers, school personnel, and health professionals. The eco‐triadic model of educational consultation may be useful as a means of providing indirect and direct services to children and adolescents with cancer. This article provides a description of the model, describes the model's application to school psychologists' work with this unique population of children, provides checklists to help guide school psychologists' intervention throughout the school reintegration process, and highlights implications for school psychology practice. © 2009 Wiley Periodicals, Inc.
Analysis of author affiliation across four school psychology journals from 2000 to 2008: Where is the practitioner research?
Authors: Carroll Erin E. , Skinner Christopher H. , McCleary Daniel F. , von Mizener Briana Hautau , Bliss Stacy L. 
Published: June 2009

AbstractArticles published between 2000 and 2008 in four major school psychology journals—School Psychology Review, Journal of School Psychology, Psychology in the Schools, and School Psychology Quarterly—were classified based on type (empirical or narrative) and on the primary and secondary authors' affiliations. Results showed that more than 90% of the primary and secondary authors were university affiliated with little difference across article type. Although more than 85% of school psychologists are practitioners, these results suggest that their contributions to these school psychology journals are limited because they account for less than 10% of the authors of articles. Discussion focuses on practitioners' involvement in the research base that is intended to inform their professional behaviors. © 2009 Wiley Periodicals, Inc.