bluuebunny/crossref_metadata_2025_split huggingface dataset:
What Matters to Senior Secondary Students in RE: An Australian Case Study That Compares an Innovative Curriculum with Traditional Approaches
Authors: Sultmann William , Lamb Janeen , Ivers Peter , Craig Mark 
Published: February 2025

Abstract
Students’ (N = 353) in the senior secondary school rated the significance of Topics, Pedagogies and Outcomes for Religious Education (RE) courses: two with an academic focus, combined and named Other RE; and one, an innovative curriculum, using a reconceptualist approach, named Religion Meaning and Life (RML). The topics of Ethics and Other World Religions were preferenced by all RE students independent of the course studied. However, students studying RML held significant and more positive perceptions for topics of Jesus and Other World Religions. All students affirmed pedagogies based on dialogue about life’s real world problems, which for the RML students was significantly more positive and fundamental to their course. Course outcomes for RML students were also significantly more positive in terms of: Listening to others; Dialoguing; Making connections; Understanding myself; and contributing to the community. While both academic and innovative approaches had different purposes, and both were valued, the reconceptualist approach within the innovative program achieved significantly better outcomes for students and aligned with the Educational Sustainable Development (ESD) goals for learning more generally. Implications centred on the potential inclusion of RML course characteristics for enhancing learning outcomes in Other RE courses and highlighted the significance of aligning of ESDs across the curriculum.
Rethinking Sustainability: Contributions of Religious Literacy Education
Authors: Grelle Bruce 
Published: February 2025

Abstract
This chapter argues that we should abandon the idea that “sustainability” is about finding a way to preserve our present “system” – our prevailing economic worldview, our consumer lifestyle, and the accompanying practices and institutions. Rather, we should rethink the concept of sustainability as a tool for criticizing and rejecting as unsustainable the growth-based economic status quo and as a spur to the development of more ecologically oriented alternatives. One of the main barriers to recognizing the unsustainability of our present global political economy is the widespread influence of mainstream economic theory. A growing number of scholars have argued that the worldview presented by mainstream economics amounts to a new secular religion of sorts, a system of faith that has become dominant in today’s world. Helping students and the general public to learn more about this view of life and its far-reaching influence, and helping them to recognize and envision possible alternatives, is a main contribution that education about religions and beliefs can make to contemporary discussions of environmental, economic, and social sustainability.
Religious Education in Türkiye in Terms of Sustainable Environmental Education: An Analysis of Religious Culture and Ethical Knowledge Curriculum and Textbooks
Authors: Meydan Hasan , Kaymakcan Recep , Karaahmetoğlu Feyza 
Published: February 2025

Abstract
In modern environmental education, for a sustainable environmental management, the most frequently emphasized ethical justification is the moral responsibility of the current generation to future generations. Even though this approach directs people to protect the environment for future generations, the responsibility is indirect. This is because the environment is placed in a position that is respected not for itself but for the benefit of future generations. However, for religions, all existence deserves existential respect because it is divine in origin. It is therefore important to consider these religious theories in religious education for the development of sustainable environmental awareness. The curricula of Religious Culture and Ethics Knowledge course has been changed four times in 1982, 2000, 2006 and 2018.
In this context, this chapter aims to explore how sustainable environmental education has been evaluated in Religious Culture and Ethics Knowledge’s curricula and textbooks since 1982, as religious education has a potential to contribute significantly to sustainable environmental awareness. Moreover, it intends to make suggestions in line with better sustainable environmental education for future curriculum development and preparation of textbooks in schools’ religious education. It is understood that these curricula held the issue in the aims, values, achievements and units in different shapes and forms.
Enhanced secretion of the amyotrophic lateral sclerosis ALS-associated misfolded TDP-43 mediated by the ER-ubiquitin specific peptidase USP19
Authors: Picard Flavien , Nonaka Takashi , Belotti Edwige , Osseni Alexis , Errazuriz-Cerda Elisabeth , Jost-Mousseau Coline , Bernard Emilien , Conjard-Duplany Agnès , Bohl Delphine , Hasegawa Masato , Raoul Cédric , Galli Thierry , Schaeffer Laurent , Leblanc Pascal 
Published: February 2025

Abstract
Proteinopathies, such as amyotrophic lateral sclerosis (ALS), are marked by the accumulation of misfolded proteins that disrupt cellular processes. Eukaryotic cells have developed protein quality control systems to eliminate these aberrant proteins, but these systems often fail to differentiate between normal and misfolded proteins. In ALS, pathological inclusions primarily composed of misfolded TDP-43 are a hallmark of the disease. Recently, a novel unconventional secretion process called misfolding-associated protein secretion (MAPS) has been discovered to selectively export misfolded proteins. USP19, an Endoplasmic Reticulum-associated ubiquitin peptidase, plays a crucial role in this process. In this study, we investigated the impact of ER-anchored USP19 on the secretion of misfolded TDP-43. Here we found that USP19 overexpression significantly promotes the secretion of soluble and aggregated misfolded TDP-43, requiring both ER anchoring and ubiquitin peptidase activity. Characterization of the cellular and molecular mechanisms involved in this process highlighted the importance of early autophagosomal and late endosomal/amphisomal compartments, while lysosomes did not play a key role. By using dominant-negative mutants and small interfering RNAs, we identified that USP19-mediated secretion of misfolded TDP-43 is modulated by key factors involved in cellular trafficking and secretion pathways, such as ATG7, the ESCRT-O HGS/HRS, the Rab GTPases RAB11A, RAB8A, and RAB27A, and the v-SNARE VAMP7. We also confirmed the crucial role of the DNAJC5/CSPα cochaperone. Overall, this study provides new insights into how cells manage the secretion of misfolded TDP-43 proteins and potentially opens new avenues for therapeutic interventions in ALS and related disorders.
Effect of pre-existing psychiatric treatment in suicidal jumpers on the need for in-hospital treatment following injury
Authors: Rantala Rolle , Heinänen Mikko , Kuorikoski Joonas , Brinck Tuomas , Söderlund Tim 
Published: February 2025

Abstract

Purpose
To study the effect of pre-existing psychiatric disorders on outcome following suicidal jump from a height.

Methods
Suicidal jumpers were identified from Helsinki Trauma Registry from 2006 to 2015. Trauma registry data were combined with administrative registry data to obtain long-term mortality and in-hospital treatment. The in-hospital treatment data was from 2 years preceding the index injury and up to 5 years post injury. Reasons for the in-hospital visits were also recorded. We analyzed the patients in two groups, namely patients without a pre-existing psychiatric diagnosis (group 1) and patients with a pre-existing psychiatric diagnosis (group 2).

Results
One-hundred twenty-seven patients were included in the analysis, with 73 patients having received pre-existing psychiatric treatment. A total of 57% of patients were males and 28% of patients suffered severe traumatic brain injury (head AIS ≥ 3). Group 2 patients had a higher number of in-hospital days pre- and post-injury than group 1 patients. Reason for in-hospital treatment in group 2 was psychiatric in over 80% of days except in the year beginning from the index injury. 30-day mortality was similar between the groups 1 and 2 (11% vs. 16%, p = 0.395). Five-year survival was 72% in group 2 patients to 86% in group 1 patients (p = 0.0001).

Conclusion
Patients with pre-existing psychiatric disorder reaching hospital alive have higher pre- and post-injury requirements for in-hospital treatment than patients without a pre-existing psychiatric disorder. Although pre-existing psychiatric disorder does not affect early mortality, long-term mortality is increased by 14%.

Trial registration
Trial registration number and date of registration: HUS/221/2017, 30.3.2017.
Effect of NADPH oxidase inhibitor apocynin on human lung cancer A549 cells via Bcl-2, Bax, caspase-3, and NF-κB signaling pathway
Authors: Yıldırım Betul Apaydın , Dogan Tuba , Bolat İsmail , Ozcan Ali Can , Kocak Rabia 
Published: February 2025

Abstract
Apocynin (AP) is an anti-inflammatory drug with different therapeutic effects. This study aimed to investigate the antiproliferative, apoptotic, and antioxidant effects of AP on human lung adenocarcinoma cells (A549) and to investigate the effects on Bax, Bcl-2, NF-κB, and caspase-3 signaling pathways that may play a role in the pathogenesis of lung cancer. Cell viability was measured by MTT and cell apoptosis, and detection of cell death was measured by ELISA. IMA, AOPP, MDA, and GSH levels, SOD and CAT activities, and Bcl-2, Bax, NF-κB, and caspase-3 expression levels were analyzed from the obtained cell lysates. As a result, according to the findings obtained, IMA and MDA levels decreased in the A549 cancer cell line, while GSH levels and SOD and CAT activity increased. It was determined that the application of apocynin to A549 cells significantly reduced cell viability and directed the cells to apoptosis, increased Bax, NF-κB, and caspase-3 expression, and decreased Bcl-2 expressions. Since all of the data obtained were not found in the literature about the use of apocynin in the A549, the study conducted is pioneering. Our study demonstrates the potential of apocynin for cancer therapy possibly targeting the apoptotic pathway.

Graphical Abstract
MRI of pediatric ovarian masses: validation of the O-RADS framework
Authors: Munari Alice M. , Monti Caterina B. , Viglio Camilla , Folco Gianluca , Rizzetto Francesco , Zirpoli Salvatore 
Published: February 2025

Abstract

Objective
The purpose of our study was to test the applicability and implications of using the O-RADS system, which is developed and validated on adults, to review MRI of ovarian masses among pediatric patients.

Materials and methods
We retrospectively reviewed consecutive MRI examinations from pediatric patients referred to imaging for suspected ovarian lesions, assessing them using the O-RADS framework. Malignancy frequencies among O-RADS classes were reviewed, and we appraised the potential for such approach to split patients into low (O-RADS 1, 2, and 3) and high risk (O-RADS 4 and 5). Multivariate analyses were conducted to review which clinical or imaging variables yielded a significant impact on malignancy, and a simplified reading framework was proposed accordingly.

Results
109 female patients were included, with a median age of 13 years (IQR 11–15 years), 7 (7%) presenting with malignant lesions. Malignancy proportions were 0% (95% confidence Interval (CI) 0–35%) for the O-RADS 1 class, 0% (95% CI 0 − 5%) for the O-RADS 2 class, 0% (95% CI 0–14%) for the O-RADS 3 class, 50 (95% CI 1 − 99%) for the O-RADS 4 class, and 75% (95% CI 41–93%) for the O-RADS 5 class. The presence of peritoneal thickening or nodules (p < 0.001), lesion composition (p < 0.001), and absence of intralesional fat (p = 0.051) were individual predictors of malignancy, and the simplified reading framework proposed with such variables identified 11 likely malignant cases, detecting all 7 malignant lesions.

Conclusion
The O-RADS system may be applied to MRI performed in the pediatric population for ovarian masses, and a simplified reading framework based on O-RADS could also prove useful in such a setting.

Key Points

Question
The Ovarian-Adnexal Reporting and Data System (O-RADS) provides the risk of malignancy of ovarian masses among adults but has not been validated among pediatric patients.

Findings Malignancy frequencies for O-RADS classes 1, 2, 3, and 4 were 0, 0, 50%, and 75%, indicating a good accuracy in lesion discrimination.

Clinical relevance
The Ovarian-Adnexal Reporting and Data System (O-RADS) can be effectively applied to MRI examinations in pediatric patients, enabling accurate classification of findings, with potential for score simplification in this age group.
Parenting Experiences in the Context of Parental Bipolar Disorder: A Systematic Review and Meta-Synthesis of the Qualitative Literature
Authors: Tu En-Nien , Saunders Kate E. A. , Manley Helen , Lobban Fiona , Jones Steven , Creswell Cathy 
Published: February 2025

Abstract
Parental bipolar disorder (BD) is associated with an increased risk of mental health problems in children. Despite the urgent need for clear guidance on how best to support parents with BD, current research lacks a unified analysis of the challenges and needs faced by these parents and their children. This review aims to explore the impact of BD on experiences of parent–child interactions or relationships to inform effective policies and interventions. Following a preregistered PROSPERO protocol, we searched Medline, Embase, PsycINFO, SCOPUS, and CINAHL for qualitative studies on parents with BD and their children (under 19 years) published since 1994. Each study was independently screened and jointly assessed for quality using the Critical Appraisal Skills Program. Our thematic synthesis entailed coding in NVivo, followed by collaborative theme generation on the Miro platform. We reviewed 19 studies, of which 9 studies reported on parents, 8 on children, and 2 on both parents and children. Our analysis generated four themes: (1) "The multifaceted landscape of parenting with BD," which outlines how mood swings affect parenting in diverse ways; (2) "The evolving dynamic of child-parent relationship amidst parental BD," including how children adapt and grow in understanding and responsibility in response to their parent’s BD; (3) "The dual nature of childcare for parents with BD," which explores how childcare impacts parents’ emotions and motivations, bringing both uplifting and challenging effects; (4) "Navigating parental challenges in the context of BD," highlighting the importance of open communication, self-reflection, and timely, unbiased support to mitigate challenges associated with parental BD. This qualitative synthesis focuses specifically on the parenting experiences of families affected by parental BD. It highlights the complex, dynamic impact of BD on parenting behaviors and children’s coping mechanisms, calling for tailored therapeutic interventions that benefit both parents and children. The scope of our study is limited by factors such as a predominance of Western perspectives and an underrepresentation of fathers’ experiences, highlighting the need for more diverse research in this area.
The effects of anti-galactagogue (sage, parsley extract) and anti-inflammatory (echinacea extract) feed supplements on prolactin levels and fertility in the re-pregnancy of lactating Merino ewes
Authors: Kutlu Metehan , Akbulut Neffel Kürşat 
Published: February 2025

Abstract
The purpose of this study was to examine the effects of anti-galactagogue (sage, parsley extract) and anti-inflammatory (echinacea extract) feed supplements on prolactin levels and fertility in the re-pregnancy of lactating Merino ewes. Eighty ewes were randomly assigned to one of two groups: control and treatment. In treatment group (Stop Lactin) group (n = 40) ewes were treated with Stop Lactin® 60 ml on day 0 orally by syringe. The control group (Control) (n = 40), ewes were not treated with any anti-galactagogue feed supplements. On day 0, a vaginal sponge containing 60 mg of medroxyprogesterone acetate was inserted for seven days. On day 7, all ewes received an intramuscular injection of 500 IU PMSG. The study results indicated no statistically significant differences between the Control group and Stop Lactin group in terms of conception rates (87.2% and 78.1%), late embryonic-early fetal mortality rate (20.6% and 8.0%), lambing rate (79.4% and 92%), twin rate (29.6% and 13.0%) and litter size (1.30 and 1.13). Estrus rates (97.5% and 82.1%, p = 0.050) tended to be higher and pregnancy rates (85.0% and 64.1%, p = 0.037) was found to be significant in the control group compared to the Stop Lactin group. The effect of treatment (P = 0.209) on serum prolactin levels and the interaction between treatment × day (P = 0.874) were both found to be insignificant. It is concluded that anti-galactagogue and anti-inflammatory feed supplements did not reduce prolactin concentration and did not improve fertility in lactating Merino ewes.
Tribological Characterization of Friction-induced Phase Transformations in Binary Nitinol
Authors: Hafezi Mahshid , Allen Jack , Abbott Andrew P. , Feeney Andrew 
Published: February 2025

Abstract
The binary alloy of nickel and titanium, commonly known as Nitinol, is widespread in the biomedical industry such as vascular stents. Recently, Nitinol’s application potential has expanded, including as actuating materials in ultrasonic transducers and robotic systems. In such cases, the temperature-dependent elastic moduli of Nitinol can be controlled via mechanical load or temperature triggers, between those for compliant martensite and stiff austenite. However, we have limited the understanding of the contact mechanics, predominantly the surface reactions and wear rate, of binary Nitinol in contact with other materials. The importance of this is understanding how Nitinol can be integrated in a wider range of industrial applications. Here, tribological investigations are undertaken to assess the phase transformation and contact mechanics of Nitinol under friction conditions, for stainless steel and titanium, chosen as common interfacing materials in actuation systems such as ultrasonic transducers. Experimental results demonstrate the phase transition from martensite to austenite via changes of elasticity in shape memory Nitinol rubbing against stainless steel under a dry condition. During these interactions, Nitinol exhibits a mass reduction of 0.00091 g, with a wear depth of 1.7 µm. Thermal analysis revealed that the austenite start temperature (As) is very close to ambient room temperature, at 25ºC. A multiple-load cycle indentation using a three-sided diamond tip was employed to evaluate the response of Nitinol to localized applied forces, where martensitic Nitinol has experienced a maximum force of 490 mN. Microscopic observations confirm the formation of oxide layers on Nitinol’s surface resulting from titanium exposure to oxygen. Meanwhile, the nonlinear hardness for martensitic Nitinol has been exhibited with increasing depth of penetration, exhibiting a maximum of 4.5 GPa. The novelty of the research is centered on both the tribological and mechanical performance of Nitinol-based actuating systems for a wide range of medical and industrial applications.
Endoscopic Approach to Laryngeal Schwannoma: A Case Report
Authors: Garg Akanksha , Kath Anmol , Handa Prince , Vermani Akshit 
Published: February 2025

Abstract
Laryngeal schwannoma is an uncommon clinical condition. This study reports the case of 78-year-old female with history of voice change. The tumour was removed by transoral endoscopic approach. On follow up the patient was symptom free. The aim of this report is to advert comprehension about this rare disease.
Automated Sample Treatment System for Enhanced Molecular Pathogen Detection in Blood
Authors: Lee Jinyeop , Abafogi Abdurhaman Teyib , Lee Tae Jae , Park Sungsu 
Published: February 2025

Abstract
Clinical samples contain various biological substances, such as proteins and lipids, which can inhibit molecular detection of pathogens, often present at concentrations below the limit of detection (LOD). While existing sample preparation techniques can remove inhibitors and enrich pathogens, they are generally labor-intensive, manual processes that increase the risk of exposure. We present a fully automated sample treatment system that integrates immunomagnetic separation (IMS) and DNA extraction within a microfluidic film device, specifically designed to streamline pathogen detection from clinical samples. The system can process up to 1 mL of whole blood and concentrate the final eluent to 20 µL, obtaining purified DNA in less than 1 h. When combined with PCR or quantitative PCR (qPCR), the system detects Escherichia coli O157 at concentrations as low as 1 CFU/mL in spiked whole blood—achieving a sensitivity 100 times greater than PCR or qPCR alone. This enhanced sensitivity is due to the effective integration of bacterial pre-concentration and DNA purification steps, which remove PCR inhibitors and improve detection in complex sample matrices, such as blood. These results demonstrate that our automated system is highly suitable for rapid, sensitive pathogen diagnostics in clinical settings, with potential for further adaptation to a wide range of pathogens and sample types, advancing molecular diagnostics for healthcare applications.
Assessing the Time of Emergence of Marine Ecosystems From Global to Local Scales Using IPSL‐CM6A‐LR/APECOSM Climate‐To‐Fish Ensemble Simulations
Authors: Barrier Nicolas , Maury Olivier , Seferian Roland , Santana‐Falcón Yeray , Tidd Alex , Lengaigne Matthieu 
Published: February 2025

AbstractClimate change is anticipated to considerably reduce global marine fish biomass, driving marine ecosystems into unprecedented states with no historical analogs. The Time of Emergence (ToE) marks the pivotal moment when climate conditions (i.e., signal) deviate from pre‐industrial norms (i.e., noise). Leveraging ensemble climate‐to‐fish simulations from one Earth System Model (IPSL‐CM6A‐LR) and one Marine Ecosystem Model (APECOSM), this study examines the ToE of epipelagic, migratory and mesopelagic fish biomass alongside their main environmental drivers for two contrasted climate‐change scenarios. Globally averaged biomass signals emerge over the historical period. Epipelagic biomass decline emerged earlier (1950) than mesozooplankton decline (2017) due to a stronger signal in the early 20th century, possibly related to trophic amplification induced by an early emerging surface warming (1915). Trophic amplification is delayed for mesopelagic biomass due to postponed warming in the mesopelagic zone, resulting in a later emergence (2017). ToE also displays strong size class dependence, with epipelagic medium sizes (20 cm) experiencing delayed emergence compared to the largest (1 m) and smallest (1 cm) categories. For the epipelagic and mesopelagic communities, the regional signal emergence lags behind the global average, with median ToE estimates of 2030 and 2034, respectively. This is due to stronger noise in regional time‐series than in global averages. The regional ToEs are also spatially heterogeneous, driven predominantly by the signal pattern akin to mesozooplankton. Additionally, our findings underscore that mitigation efforts (i.e., transitioning from SSP5‐8.5 to SSP1‐2.6 scenario) can potentially curtail emerging ocean surface signals by 30%.