bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vanadium in silicon carbide: telecom-ready spin centres with long relaxation lifetimes and hyperfine-resolved optical transitions
Authors: Astner Thomas , Koller Philipp , Gilardoni Carmem M , Hendriks Joop , Tien Son Nguyen , Ivanov Ivan G , Ul Hassan Jawad , van der Wal Caspar H , Trupke Michael 
Published: May 2024

Abstract
Vanadium in silicon carbide (SiC) is emerging as an important candidate system for quantum technology due to its optical transitions in the telecom wavelength range. However, several key characteristics of this defect family including their spin relaxation lifetime (T1), charge state dynamics, and level structure are not fully understood. In this work, we determine the T1 of an ensemble of vanadium defects, demonstrating that it can be greatly enhanced at low temperature. We observe a large spin contrast exceeding 90% and long spin-relaxation times of up to 25 s at 100 mK, and of order 1 s at 1.3 K. These measurements are complemented by a characterization of the ensemble charge state dynamics. The stable electron spin furthermore enables high-resolution characterization of the systems’ hyperfine level structure via two-photon magneto-spectroscopy. The acquired insights point towards high-performance spin-photon interfaces based on vanadium in SiC.
Perspective on new implementations of atomtronic circuits
Authors: Polo Juan , Chetcuti Wayne J , Domanti Enrico C , Kitson Philip , Osterloh Andreas , Perciavalle Francesco , Singh Vijay Pal , Amico Luigi 
Published: May 2024

AbstractIn this article, we provide perspectives for atomtronics circuits on quantum technology platforms beyond simple bosonic or fermionic cold atom matter-wave currents. Specifically, we consider (i) matter-wave schemes with multi-component quantum fluids; (ii) networks of Rydberg atoms that provide a radically new concept of atomtronics circuits in which the flow, rather than in terms of matter, occurs through excitations; (iii) hybrid matterwave circuits—a combination of ultracold atomtronic circuits with other quantum platforms that can lead to circuits beyond the standard solutions and provide new schemes for integrated matter-wave networks. We also sketch how driving these systems can open new pathways for atomtronics.
Customized heat treatment process enabled excellent mechanical properties in wire arc additively manufactured Mg-RE-Zn-Zr alloys
Authors: Ma Dong , Xu Chunjie , Sui Shang , Qi Yuanshen , Guo Can , Zhang Zhongming , Tian Jun , Zeng Fanhong , Remennik Sergei , Shechtman Dan 
Published: May 2024

Abstract
Customized heat treatment is essential for enhancing the mechanical properties of additively manufactured metallic materials, especially for alloys with complex phase constituents and heterogenous microstructure. However, the interrelated evolutions of different microstructure features make it difficult to establish optimal heat treatment processes. Herein, we proposed a method for customized heat treatment process exploration and establishment to overcome this challenge for such kind of alloys, and a wire arc additively manufactured (WAAM) Mg-Gd-Y-Zn-Zr alloy with layered heterostructure was used for feasibility verification. Through this method, the optimal microstructures (fine grain, controllable amount of long period stacking ordered (LPSO) structure and nano-scale β′ precipitates) and the corresponding customized heat treatment processes (520 °C/30 min + 200 °C/48 h) were obtained to achieve a good combination of a high strength of 364 MPa and a considerable elongation of 6.2%, which surpassed those of other state-of-the-art WAAM-processed Mg alloys. Furthermore, we evidenced that the favorable effect of the undeformed LPSO structures on the mechanical properties was emphasized only when the nano-scale β′ precipitates were present. It is believed that the findings promote the application of magnesium alloy workpieces and help to establish customized heat treatment processes for additively manufactured materials.
Main Partner Relationships and the HIV Care Cascade: Examining the Predictive Utility of Sexual Agreements, Partner Concordance, and Drug Use Among Sexual Minority Men Living With HIV in the USA
Authors: Starks Tyrel J , Sauermilch Daniel , Doyle Kendell M , Kalichman Seth , Cain Demetria 
Published: May 2024

Abstract

Background
The past 15 years have seen increasing attention to relationship factors among sexual minority male (SMM) couples at high risk for HIV infection. Research has largely focused on HIV prevention outcomes. Outcomes relevant to SMM living with HIV have received relatively less attention.

Purpose
This study evaluated associations between relational covariates (relationship status, sexual agreements, and seroconcordance) and HIV care cascade outcomes (having a current antiretroviral therapy [ART] prescription, ART adherence, viral load (VL) testing, and VL detectability) above and beyond cannabis and stimulant drug use.

Methods
Adult SMM (n = 36,874) living with HIV in the USA were recruited between November 1, 2017 and March 15, 2020 through social networking applications. They completed a cross-sectional survey online.

Results
Nonmonogamous SMM with serodiscordant partners were most likely to have an ART prescription. Those with seroconcordant partners (regardless of sexual agreements) were least likely to be adherent. While relational covariates were not associated with VL testing, SMM in nonmonogamous relationships with serodiscordant partners were significantly more likely to have an undetectable VL. Those in monogamous relationships with seroconcordant partners were significantly less likely to have an undetectable VL.

Conclusions
SMM with seroconcordant partners and monogamous sexual agreements may experience diminished interpersonal motivation for HIV care engagement. HIV care cascade retention messages that emphasize the prevention of onward transmission may have limited relevance for these SMM. Novel intervention strategies are needed to enhance HIV care outcomes in this population, ideally ones that incorporate attention to drug use.
A Single Bout of Prolonged Sitting Augments Very Short-Term Blood Pressure Variability
Authors: Waghorn Jocelyn , Liu Haoxuan , Wu Yanlin , Rayner Sophie E , Kimmerly Derek S , O’Brien Myles W 
Published: May 2024

Abstract

BACKGROUND
More habitual time spent engaging in prolonged sedentary behaviors increases the risk of developing hypertension. Beat-by-beat systolic (SBPV) and diastolic blood pressure variability (DBPV) are more pronounced in persons with hypertension and may be an early manifestation of blood pressure dysregulation. We tested the hypothesis that a single bout of prolonged sitting augments very short-term SBPV and DBPV. The secondary aim was to explore sex differences in prolonged sitting-induced increases in SBPV and DBPV.

METHODS
Thirty-three adults (22.9 ± 1.9 years; 17 females) completed a single, 3-hour bout of prolonged sitting with beat-by-beat arterial pressure determined at baseline, 1.5-hour, and 3-hour via finger photoplethysmography.

RESULTS
There were no sex differences observed for baseline brachial SBP (males: 122 ± 10 mm Hg; females: 111 ± 9 mm Hg), SBPV (males: 1.87 ± 0.63 mm Hg; females: 1.51 ± 0.38 mm Hg), DBP (males: 68 ± 6 mm Hg; females: 66 ± 8 mm Hg), or DBPV (males: 1.40 ± 0.41 mm Hg; females: 1.27 ± 0.32 mm Hg) (all, P &gt; 0.41). In the pooled sample, baseline SBPV (1.68 ± 0.54 mm Hg) remained unchanged after 1.5 hours (1.80 ± 0.60 mm Hg; P = 0.59) but increased after 3.0 hours (1.84 ± 0.52 mm Hg; P = 0.01). This post-sitting increase was driven by males (P = 0.009), with no difference observed in females (P = 1.00). Similarly, baseline DBPV (1.33 ± 0.36 mm Hg) was similar after 1.5 hours (1.42 ± 0.41 mm Hg; P = 0.72) but was increased at 3 hours (1.50 ± 0.34 mm Hg; P = 0.02). However, no sex differences in DBPV (all, P &gt; 0.07) were observed across the time points.

CONCLUSIONS
In young, normotensive adults, a single bout of prolonged sitting augmented beat-by-beat blood pressure variability, which may provide a link between uninterrupted sitting and the development of blood pressure dysregulation.
Assessing the impact of authorisation process as a regulatory tool in the European REACH regulation: A study on improving occupational safety for applying companies
Authors: Deubner Holger-Lars , Walendzik Gudrun , Lüdeke Andreas , Schlüter Urs 
Published: May 2024

Abstract
This study looks into the effectiveness of the authorisation procedure as a regulatory instrument within the framework of the European REACH regulation. It highlights its impact on enhancing occupational safety and health for both applicants and companies utilising the substances. This procedure encompasses manufacturers, importers, and downstream users of substances, as well as representatives of foreign manufacturers who are also eligible to seek authorisation. When applying for authorisation, the ECHA Risk Assessment Committee (RAC) assesses the risks associated with the intended uses of the substance, including the appropriateness and effectiveness of the Occupational Conditions (OCs) and Risk Management Measures (RMMs) described in the application and the risks posed by potential alternatives. If the RAC determines that the OCs/RMMs are inadequate for managing or controlling the risk, or if the measures to protect workers are deemed insufficient, it may recommend additional measures to enhance occupational safety and health or environmental protection. The 398 processed Applications for Authorisation (AfA) that have been submitted to date were examined to determine these recommended measures, categorised as Conditions for use, Monitoring arrangements, and Recommendations for Review Reports. Overall, a significant improvement concerning occupational safety and health seems necessary, as indicated by the large number of measures recommended by the ECHA Committee for Risk Assessment (RAC) and ECHA Committee for Socio-economic Analysis (SEAC) or supplemented by the European Commission. In addition to the proposed measures, a short assessment provided by the committees as to whether the operational conditions and risk management measures are adequate in controlling the risks is also included in the study.
From cell lines to cancer patients: personalized drug synergy prediction
Authors: Kuru Halil Ibrahim , Cicek A Ercument , Tastan Oznur 
Published: May 2024

Abstract

Motivation
Combination drug therapies are effective treatments for cancer. However, the genetic heterogeneity of the patients and exponentially large space of drug pairings pose significant challenges for finding the right combination for a specific patient. Current in silico prediction methods can be instrumental in reducing the vast number of candidate drug combinations. However, existing powerful methods are trained with cancer cell line gene expression data, which limits their applicability in clinical settings. While synergy measurements on cell line models are available at large scale, patient-derived samples are too few to train a complex model. On the other hand, patient-specific single-drug response data are relatively more available.

Results
In this work, we propose a deep learning framework, Personalized Deep Synergy Predictor (PDSP), that enables us to use the patient-specific single drug response data for customizing patient drug synergy predictions. PDSP is first trained to learn synergy scores of drug pairs and their single drug responses for a given cell line using drug structures and large scale cell line gene expression data. Then, the model is fine-tuned for patients with their patient gene expression data and associated single drug response measured on the patient ex vivo samples. In this study, we evaluate PDSP on data from three leukemia patients and observe that it improves the prediction accuracy by 27% compared to models trained on cancer cell line data.

Availability and implementation
PDSP is available at https://github.com/hikuru/PDSP.
DeepPPAPredMut: deep ensemble method for predicting the binding affinity change in protein–protein complexes upon mutation
Authors: Nikam Rahul , Jemimah Sherlyn , Gromiha M Michael 
Published: May 2024

Abstract

Motivation
Protein–protein interactions underpin many cellular processes and their disruption due to mutations can lead to diseases. With the evolution of protein structure prediction methods like AlphaFold2 and the availability of extensive experimental affinity data, there is a pressing need for updated computational tools that can efficiently predict changes in binding affinity caused by mutations in protein–protein complexes.

Results
We developed a deep ensemble model that leverages protein sequences, predicted structure-based features, and protein functional classes to accurately predict the change in binding affinity due to mutations. The model achieved a correlation of 0.97 and a mean absolute error (MAE) of 0.35 kcal/mol on the training dataset, and maintained robust performance on the test set with a correlation of 0.72 and a MAE of 0.83 kcal/mol. Further validation using Leave-One-Out Complex (LOOC) cross-validation exhibited a correlation of 0.83 and a MAE of 0.51 kcal/mol, indicating consistent performance.

Availability and implementation
https://web.iitm.ac.in/bioinfo2/DeepPPAPredMut/index.html.
Mobilizing Metaphors in Criminological Analysis: A Case Study of Emotions in the Penal Voluntary Sector
Authors: Quinn Kaitlyn , Buck Gillian , Tomczak Philippa 
Published: May 2024

Abstract
Metaphors pervade media and political constructions of crime and justice, provoking responses and shaping actions. Scholarship in adjacent disciplines illustrates that emotion-metaphors offer unique insight into emotional and interpretive processes, valuably illuminating sense-making, problem solving and action. Yet, metaphors are rarely analysed within criminology, leaving an important opportunity for theorizing emotions and their implications largely unrealized. We explore the analytical and theoretical potential of emotion-metaphors for criminology, using empirical research conducted in the penal voluntary sectors of England and Scotland. Drawing on focus groups with volunteers and paid staff, we analyse the metaphors that non-profit practitioners mobilized to convey how their work felt: (1) absurd and unstable, (2) vulnerable and constrained, (3) devalued and discarded and (4) risky and all-consuming.
LC and LC–MS/MS Studies for the Separation and Identification of Impurities and Degradation Products of Betaxolol
Authors: Chmangui Anis , Safta Mehdi , Driss Mohamed Ridha , Touil Soufiane , Bouabdallah Sondes 
Published: May 2024

Abstract
Betaxolol (Bx) is a selective β1 receptor blocker used in the treatment of hypertension and glaucoma. The aim of the present work was to demonstrate an approach involving use of liquid chromatography (LC) and liquid chromatography-electrospray ionization mass spectrometry (LC-ESI/MS) for the simultaneous separation, identification and characterization of impurities and of degradation products of betaxolol without their isolation from the reaction mixtures. At optimum condition, and according to ICH guidelines, the limit of detection (LOD) and limit of quantification (LOQ) for Bx are found to be 5.46 and 16.54 μg mL−1, respectively. However, the LOD and LOQ for the major degradation product P6 were 2.15 and 6.53 μg mL−1. Betaxolol was subjected to hydrolytic (acidic and basic) and oxidative, stress conditions according to International Conference on Harmonization (ICH) guideline Q1A (R2), and as results, the drug was found to be labile in acidic, basic and oxidative stress conditions. Based on LC-ESI/MS analysis, the found results revealed that Bx decomposes in acidic, basic and oxidizing environments. All degradation products were identified with the help of their fragmentation pattern and the masses obtained upon the MS analysis.
Enhancing Legal Convergence in the GBA through Harmonization of the Digital Dispute Resolution Legal Framework
Authors: Chen Hui , Zhao Yun 
Published: May 2024

Abstract
This article examines theories of legal convergence and the practice of rule harmonization for online dispute resolution (ODR) in the Greater Bay Area (GBA). The ODR platforms in the GBA employ collaborative mechanisms, institutional alliances, international standards, and multi-jurisdiction remote hearings to promote the convergence of ODR rules. However, to date, the efforts made to promote ODR rule harmonization have not resolved the fundamental issue of a lack of uniform ODR legislation within the GBA. It is posited here that an independent model of legal convergence would be more applicable in the GBA context. The article calls for the GBA Legal Department Joint Conferences to provide general ODR standards and principles, with specific laws and regulations then formulated in the respective jurisdictions. Public and private ODR providers are found to play distinct roles in legal convergence, and specialized procedural rules should be formulated to ensure due process and cybersecurity in remote hearings.
Urbanization does not affect red foxes’ interest in anthropogenic food, but increases their initial cautiousness
Authors: Lazzaroni Martina , Brogi Rudy , Napolitano Valentina , Apollonio Marco , Range Friederike , Marshall-Pescini Sarah 
Published: May 2024

Abstract
Human presence and activities have profoundly altered animals’ habitats, exposing them to greater risks but also providing new opportunities and resources. The animals’ capacity to effectively navigate and strike a balance between risks and benefits is crucial for their survival in the Anthropocene era. Red foxes (Vulpes vulpes), adept urban dwellers, exhibit behavioral plasticity in human-altered environments. We investigated variations in detection frequency on trail cameras and the behavioral responses (explorative, bold, and fearful) of wild red foxes living along an urbanization gradient when exposed to a metal bin initially presented clean and then filled with anthropogenic food. All fox populations displayed an increased interest and similar explorative behavioral responses toward the anthropogenic food source, irrespective of the urbanization gradient. Despite no impact on explorative behaviors, foxes in more urbanized areas initially showed heightened fear toward the empty bin, indicating increased apprehension toward novel objects. However, this fear diminished over time, and in the presence of food, urban foxes displayed slightly reduced fear compared with their less urban counterparts. Our results highlight foxes’ potential for adaptability to human landscapes, additionally underscoring the nuanced interplay of fear and explorative behavioral response of populations living along the urbanization gradient.
Colorectal Cancer in Inflammatory Bowel Disease: A Review of the Role of Gut Microbiota and Bacterial Biofilms in Disease Pathogenesis
Authors: Muñiz Pedrogo David A , Sears Cynthia L , Melia Joanna M P 
Published: May 2024

Abstract
The risk of colorectal cancer [CRC] is increased in patients with inflammatory bowel disease [IBD], particularly in extensive ulcerative colitis [UC] and Crohn’s colitis. Gut microbiota have been implicated in the pathogenesis of CRC via multiple mechanisms, including the release of reactive oxygen species and genotoxins, and induction of inflammation, as well as activation of the immune response. Gut microbiota can enhance their carcinogenic and proinflammatory properties by organising into biofilms, potentially making them more resistant to the host’s immune system and to antibiotics. Colonic biofilms have the capacity to invade colonic tissue and accelerate tumorigenesis in tumour-prone models of mice. In the context of IBD, the prevalence of biofilms has been estimated to be up to 95%. Although the relationship between chronic inflammation and molecular mediators that contribute to IBD-associated CRC is well established, the role of gut microbiota and biofilms in this sequence is not fully understood. Because CRC can still arise in the absence of histological inflammation, there is a growing interest in identifying chemopreventive agents against IBD-associated CRC. Commonly used in the treatment of UC, 5-aminosalicylates have antimicrobial and anticarcinogenic properties that might have a role in the chemoprevention of CRC via the inhibition or modulation of carcinogenic gut microbiota and potentially of biofilm formation. Whether biologics and other IBD-targeted therapies can decrease the progression towards dysplasia and CRC, via mechanisms independent of inflammation, is still unknown. Further research is warranted to identify potential new microbial targets in therapy for chemoprevention of dysplasia and CRC in IBD.
What factors influence the uptake of bowel, breast and cervical cancer screening? An overview of international research
Authors: Prowse Sarah R , Brazzelli Miriam , Treweek Shaun 
Published: May 2024

Abstract

Background
For cancer screening programmes to be effective in early detection it is important that those invited can access screening services and understand the benefits of participation. A better understanding of the factors that matter to potential participants of cancer screening programmes can assist in developing strategies to increase current uptake.

Methods
We conducted an overview of systematic reviews to answer the question: What factors influence the uptake of cancer screening services (breast, bowel and cervical) in high-income countries? A thematic approach supported by tabular summaries and qualitative heat maps was used to categorize factors, described as ‘barriers’ or ‘facilitators’.

Results
A total of 41 systematic reviews met the criteria for inclusion. The barrier with the greatest number of ‘hot spots’ across all three screening programmes was a fear of the unknown regarding a possible diagnosis of cancer or abnormal screening results, followed closely by a general lack of knowledge surrounding cancer screening programmes. The greatest collective facilitator to uptake was recommendation by a healthcare provider to attend screening.

Conclusion
Across all factors ‘trust’ and ‘building trusted relationships’ can be seen as integral to the success of cancer screening programmes and must be reflective of collaborative efforts to mitigate barriers and enhance facilitators to uptake. There is future scope to consider interventions that (i) increase demand for screening services, (ii) reduce barriers to uptake of services and/or (iii) are relevant to the healthcare system and those providing services.
High-latitude ocean habitats are a crucible of fish body shape diversification
Authors: Burns Michael D , Friedman Sarah T , Corn Katherine A , Larouche Olivier , Price Samantha A , Wainwright Peter C , Burress Edward D 
Published: May 2024

Abstract
A decline in diversity from the equator to the poles is a common feature of Earth’s biodiversity. Here, we examine body shape diversity in marine fishes across latitudes and explore the role of time and evolutionary rate in explaining the diversity gradient. Marine fishes’ occupation of upper latitude environments has increased substantially over the last 80 million years. Fishes in the highest latitudes exhibit twice the rate of body shape evolution and one and a third times the disparity compared to equatorial latitudes. The faster evolution of body shape may be a response to increased ecological opportunity in polar and subpolar oceans due to (1) the evolution of antifreeze proteins allowing certain lineages to invade regions of cold water, (2) environmental disturbances driven by cyclical warming and cooling in high latitudes, and (3) rapid transitions across depth gradients. Our results add to growing evidence that evolutionary rates are often faster at temperate, not tropical, latitudes.