bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomechanical testing of ex vivo porcine tendons following high intensity focused ultrasound thermal ablation
Authors: Chu Kwan William , Partanen Ari , Narayanan Unni , Waspe Adam C. , Drake James M. 
Published: May 2024

Introduction
Magnetic resonance-guided focused ultrasound (MRgFUS) has been demonstrated to be able to thermally ablate tendons with the aim to non-invasively disrupt tendon contractures in the clinical setting. However, the biomechanical changes of tendons permitting this disrupting is poorly understood. We aim to obtain a dose-dependent biomechanical response of tendons following magnetic resonance-guided focused ultrasound (MRgFUS) thermal ablation.

Methods
Ex vivo porcine tendons (n = 72) were embedded in an agar phantom and randomly assigned to 12 groups based on MRgFUS treatment. The treatment time was 10, 20, or 30s, and the applied acoustic power was 25, 50, 75, or 100W. Following each MRgFUS treatment, tendons underwent biomechanical tensile testing on an Instron machine, which calculated stress-strain curves during tendon elongation. Rupture rate, maximum treatment temperature, Young’s modulus and ultimate strength were analyzed for each treatment energy.

Results
The study revealed a dose-dependent response, with tendons rupturing in over 50% of cases when energy delivery exceeded 1000J and 100% disruption at energy levels beyond 2000J. The achieved temperatures during MRgFUS were directly proportional to energy delivery. The highest recorded temperature was 56.8°C ± 9.34 (3000J), while the lowest recorded temperate was 18.6°C ± 0.6 (control). The Young’s modulus was highest in the control group (47.3 MPa ± 6.5) and lowest in the 3000J group (13.2 MPa ± 5.9). There was no statistically significant difference in ultimate strength between treatment groups.

Conclusion
This study establishes crucial thresholds for reliable and repeatable disruption of tendons, laying the groundwork for future in vivo optimization. The findings prompt further exploration of MRgFUS as a non-invasive modality for tendon disruption, offering hope for improved outcomes in patients with musculotendinous contractures.
Acute and Long-Term Effects of App-Delivered Heartfulness Meditation on Psychological Outcomes and the Endocannabinoid Signaling System in Cyclic Vomiting Syndrome
Authors: Venkatesan Thangam , Hillard Cecilia J. , Ayer Lina , Arumugam Saranya , Culp Stacey , Vyas Mahima , Gofar Kebire , Petrova Ana , Palsson Olafur S. 
Published: May 2024

INTRODUCTION:
Cyclic vomiting syndrome (CVS) is a disorder of gut-brain interaction often triggered by stress. Interventions such as meditation may improve psychological outcomes and health-related quality of life (HRQoL), but their efficacy and the underlying mechanism are unknown.

METHODS:
We conducted a 6-week single-arm pilot study to assess the effects of heartfulness meditation (HFM) in CVS using a custom-designed meditation app. Primary outcomes included state and trait anxiety and mood state changes pre vs post-meditation, and secondary outcomes were psychological distress, coping, sleep quality, and HRQoL at baseline and at weeks 3 and 6. Serum concentrations of endocannabinoids N-arachidonylethanolamine and 2-arachidonoylglycerol and related lipids were measured pre- and post-HFM at baseline and week 6.

RESULTS:
In 30 treatment completers, there was a significant improvement in state anxiety (P < 0.001), total mood disturbance (P < 0.001), and other mood states (all P values < 0.05) across the 3 time points. Trait anxiety was also improved at week 6. There was a significant improvement in psychological distress (Global Severity Index), sleep quality (daytime dysfunction), coping (using religion/spirituality), and HRQoL (mental and physical) across the 3 time points (all P < 0.05). Significant increases in N-arachidonylethanolamine and related lipids N-oleoylethanolamine and palmitoylethanolamide post vs pre-HFM were observed at week 6 (P < 0.001, 0.002, 0.003, respectively). No adverse effects were noted.

DISCUSSION:
App-delivered HFM is feasible, safe, and effective and improves psychological outcomes and augments endocannabinoids. This provides insight into the mechanism underlying HFM and has potential for widespread use as a digital therapeutic in CVS and other disorder of gut-brain interaction.
Physiological hardware-in-the-loop test bench for mechanical ventilation
Authors: von Platen Philip , Lesch Lennard , Lohse Arnhold , Leonhardt Steffen , Walter Marian 
Published: May 2024

Abstract
This article presents a hardware-in-the-loop system that can simulate a patient’s physiological responses to mechanical ventilation. The system includes a hardware platform with a mechatronic lung that can physically simulate the respiratory mechanics. A computational patient model replicates the pressure/volume behaviour of the lungs and the impaired gas exchange. Based on current ventilator settings, the model calculates signal curves, which are then transmitted to the physically existing sensors. This enables the test bench to reproduce the pressure/volume behaviour of the lungs and the gas exchange of a simulated patient on mechanical ventilation. In the future, the hardware-in-the-loop system could play an important role in testing and validating highly automated functions in mechanical ventilation and represent an alternative to animal testing.
Design, development, and optimization of the Somnomat Casa: a rocking bed for sleep studies and nocturnal interventions in home settings
Authors: Breuss Alexander , Fujs Manuel , Müller Miriam , Suter Zelio , Wyss Nicola , Riener Robert 
Published: May 2024

Abstract
Vestibular Stimulation (VS) has been shown to positively affect various autonomic body functions, including sleep. In the past, VS was often investigated using large and complex rocking beds that would only allow for short intervention periods in constrained lab settings. In this work, we present an overview of the mechanics, kinematics, dynamics, and tuning of our latest rocking bed, the Somnomat Casa. Its compact dimensions, comparable to a standard single bed, its connectivity, and easy usability, allow for prolonged studies in home settings investigating the effects of VS during sleep. In a first six-month study with a 12-year-old boy suffering from primary mitochondrial disease with an associated severe sleep disorder, we observed significant improvements in sleep duration (+25 %) and quality of life, as well as a 75 % reduction in caregiving interactions and a 40 % reduction in overall caregiving time. Based on these promising findings, we are currently testing the Somnomat Casa with various patient groups for multiple months each, including elderly with insomnia, children with sleep disorders, Parkinson’s disease patients, and individuals with post-stroke insomnia.
Introduction: Language ideologies—again? New insights from a flourishing field
Authors: Truan Naomi , Jahns Esther 
Published: May 2024

Abstract
Originally defined as “any sets of beliefs about language articulated by the users as a rationalization or justification of perceived language structure and use” (Silverstein 1979: 193), language ideologies now seem to be “everywhere” (Cavanaugh 2019). Indeed, while language ideological research has moved “from a marginalized topic to an issue of central concern” (Kroskrity 2004: 501), and despite the abundance and regularity of new scholarly work, both theoretically and methodologically, language ideologies are still not very well framed. The Special Issue on ‘Language Ideologies: Old Questions, New Perspectives’ aims at offering diverse insights on language ideologies with a focus on methodological and theoretical questions. In this introduction in particular, we briefly map out the field by focusing on what distinguishes language ideologies from other close phenomena such as language attitudes. We also describe the methods used to access language ideologies. Finally, we introduce the ten papers that constitute this Special Issue.
Beyond warzones: conflict-stricken states as viewed by the Czech corpus collocations
Authors: Místecký Michal , Radková Lucie 
Published: May 2024

Abstract
The aim of the article is to observe how countries that have faced armed conflicts in the recent decades are perceived in a corpus of Czech, mostly journalism texts. We focus on eight countries where soldiers of the Czech Republic or the former Czechoslovak Republic have been deployed on the basis of a mandate after 1989 (Afghanistan, Bosnia and Herzegovina, Croatia, Iraq, Kosovo, Kuwait, Mali, and Yugoslavia). The picture of each country is determined via a quantitative, corpus-based approach. First, a frequency analysis is conducted in an attempt to show whether texts tend to mention some conflict-affected countries more frequently than others. Second, a collocation analysis is carried out to identify the stereotypes associated with the studied countries. The results show very different perceptions of the states, ranging from those connected solely to warfare (Iraq, Afghanistan) to those that are nowadays mostly seen as holiday destinations (Croatia). Moreover, some countries do not seem to be paid much attention at all (Mali). The outcome of the research may be of use for journalists, political scholars, and geographers and provides the respective disciplines with a new methodological approach.
Insights into marking behavior of giant anteaters: a camera trap study in the Rupununi savannahs, Guyana
Authors: Earl Erin , van Vliet Nathalie , Braga-Pereira Franciany , Millar Neal , Wilson Nathaneel 
Published: May 2024

Abstract
The Giant Anteater (Myrmecophaga tridactyla), facing threats from habitat degradation and hunting, remains a species of enigmatic behavior. This study analyzed camera trap data collected over 7700 camera trap nights in 49 stations near marked trees in Southern Guyana. A total of 883 Giant Anteater sightings were recorded, categorized into solitary adults (797), females with offspring (70), solitary juveniles (8), and paired adults (6). Meticulous observations documented various behaviors, distinguishing chemical (sniffing) and visual (scratching, climbing, hugging, rubbing) tree-marking from non-tree-marking behaviors (foraging, self-scratching, rolling, urinating/defecating). For solitary individual, a PCA revealed an inverse correlation between ignoring and sniffing (explaining 33.64 % of PC1), suggesting individuals engage in one behavior per observation. We observed an inverse correlation between hug/scratch/rub and climb (20.75 % of PC2). A weighted PCA assessing correlations by social categories, distinguishing marking behaviors from ignoring the tree (explaining 95.6 % of PC1). Scratching trees without climbing or hugging occurred from 3 pm to 1 am, with climbing most frequent between 8 and 10 pm. These behaviors were common during peak anteater sightings, peaking in May, with fewer observations in September. Overall, Giant Anteaters exhibit tree-marking behaviors, including scratching, climbing, and hugging and that a primary purpose for this behavior is communication.
Observations on the Names, Descriptions, and Drawings of Musical Instruments, Named “Ekhlegch”, “Khuraagch” and “Uelegch”
Authors: Purevdorj Davaapil 
Published: May 2024

Abstract
This article was written as a contribution to the study of Mongolian musicology, including court musicology. The musical instruments made of wood, named “Ekhlegch”, “Khuraagch” and “Uelegch” were a part of the court musical orchestra of the Great Yuan State of Mongolia although they are no longer used, their purpose is not always clear, the names, descriptions, and drawings of them have been recorded in some old sources and works of musicologists. It is believed that studying these instruments and clarifying their functions will contribute to the further development of Mongolian musical studies and the structure and composition of the orchestra. Also, it would be another interesting study to compare the hand drawings of musical instruments, which were recorded in old sources as part of the ancient Mongolian court orchestra, but have not been preserved today.
Sammy Gronemann’s “Little Mirror”: Translating Tohuwabohu into Utter Chaos
Authors: Milbouer Penny 
Published: May 2024

Abstract
Reflecting on her English translation of Sammy Gronemann’s novel Tohuwabohu (originally published in German in 1920), which was released under the title Utter Chaos in 2016, Penny Milbouer’s essay reconstructs the enthusiastic reception of the novel by Albert Einstein, a discerning and knowledgeable reader. Milbouer explores the resonance between Gronemann’s and Einstein’s perspectives on modern German Jewish identity, nationalism, and antisemitism. Her essay examines Einstein’s disillusionment with American Jews’ assimilationist tendencies and analyses reasons for the failure to recognize Gronemann’s satire. Delving into Einstein’s experiences with antisemitism in America, Milbouer describes his evolving views on Zionism, contrasting American and European Jewish identities in the “little mirror” of Gronemann’s novel. Her conclusion highlights the contemporary relevance of Gronemann’s satire and Einstein’s warnings about the persistence of antisemitism, confirming that American Jews cannot escape confronting their identity or responding to discrimination and persecution.
Crystal structure of 1–methyl-3-propyl-4-nitro-1H-pyrazole-5-carboxylic acid, C8H11N3O4
Authors: Fang Wen-Chao , Liao Xiao-Fei , Xiong Yuan-Zhen , Zhao Ping , Huang Jian-Ping 
Published: May 2024

Abstract
[C8H11N3O4], monoclinic, P21/c (no. 14), a = 4.5811(16) Å, b = 19.734(7) Å, c = 11.812(4) Å, β = 101.181(11)°, V = 1047.6(6) Å3, Z = 4, Rgt
(F) = 0.0742, wRref
(F
2) = 0.1176, T = 296(2) K.
Crystal structure of poly[(μ3-5-bromoisophthalato-κ4
O,O′ :O″,O‴)-(μ2-1,2-bis(1,2,4-triazole-1-ylmethyl)benzene-κ2
N:N′)cobalt(II)], C20H15BrCoN6O4
Authors: Xin-Tong Yao , Jin Cai , Yang Liu , Man-Sheng Chen 
Published: May 2024

Abstract
C20H15BrCoN6O4, monoclinic, P21/n (no. 14), a = 8.7395(7) Å, b = 16.1423(11) Å, c = 14.9519(12) Å, β = 103.694(3)°, V = 2049.4(3) Å3, Z = 4, R

gt
(F) = 0.0514, wR

ref
(F
2) = 0.1079, T = 193(2) K.
Navigating Government Funding During a Pandemic: A Study on Nonprofits’ Receipt of Disaster Relief Funds
Authors: Chen Xintong , Yang Zheng 
Published: May 2024

Abstract
American communities have been the hardest hit by the COVID-19 pandemic. The collaboration between governments and nonprofits is needed to satisfy the needs of the American communities. This article investigates the organizational factors of nonprofits that contribute to the obtainment of government disaster relief funds in the context of the COVID-19 pandemic by surveying nonprofits whose main offices were located in California. The findings show that, in general, having internal professionals in fundraising, and having previous experience in government applications contribute to the successful receipt of government relief funds. Moreover, different factors are associated with the receipt of relief funds from different levels of government. This article offers valuable insights to government and nonprofit funding relations and how their collaboration can enhance community resilience during times of disasters.
Exploring genes within the glutathione peroxidase family as potential predictors of prognosis in papillary renal cell carcinoma
Authors: Li Chenlu , Zhang Tao , Yan Mi , Chen Yan , Nan Ruchao , Chen Jun , Wang Xiaoyu 
Published: May 2024

Abstract

Objectives
This research aims to explore the relationship between glutathione peroxidase (GPX) expression variations in papillary renal cell carcinoma (pRCC) and patient survival, while also developing and evaluating a customized survival prediction model based on GPX.

Methods
The transcriptomic dataset, including clinical parameters and GPX expression levels, is sourced from The Cancer Genome Atlas (TCGA) database, comprising 290 individuals diagnosed with pRCC. We utilized a univariate Cox regression model to select differentially expressed genes. Subsequently, we calculated risk scores through the least absolute shrinkage and selection operator (LASSO) regression. Based on the median risk score, patients were categorized into high and low-risk groups, establishing a prognostic risk model. Following this, the relationship between the risk model and the survival of pRCC patients was revealed through Kaplan–Meier survival curve analysis. The sensitivity and specificity of the predictive model were evaluated using receiver operating characteristic (ROC) curve analysis. Furthermore, chemotherapy drug sensitivity analysis was conducted on patients in the high and low-risk groups.

Results
A risk-scoring model was built by selecting GPX7 and GPX8. Compared to the low-risk group, individuals in the high-risk category showed significantly reduced overall survival rates (p=0.018). Additionally, validation results demonstrated the model’s good predictive accuracy.

Conclusions
The risk-scoring model constructed based on GPX family genes provides an innovative biomarker for forecasting the prognosis of pRCC and serves as a reference for individualized therapy in pRCC.
The workshops on computational applications in secondary metabolite discovery (CAiSMD)
Authors: Ntie-Kang Fidele , Eni Donatus B. , Telukunta Kiran K. , Osamor Victor Chukwudi , Egieyeh Samuel A. , Duran-Frigola Miquel , Mishra Pankaj , Shadrack Daniel M. , Paul Lucas , Musyoka Thommas M. , Blin Kai , Farid Mai M. , Chen Ya , Djogang Lucie Karelle , Betow Jude Y. , Ibezim Akachukwu , Joshi Darshana , Edwin Alanis T. , Chama Mary A. , Ongagna Jean Moto , Kemdoum Sinda Pierre Valery , Metuge Jonathan A. , Bekono Boris D. , Isa Mustafa A. , Medina-Franco José L. , Weber Tilmann , Dorrestein Pieter C. , Janezic Dusanka , Bishop Özlem Tastan , Ludwig-Müller Jutta 
Published: May 2024

Abstract
We report the outcomes of the second session of the free online open-access workshop “Computational Applications in Secondary Metabolite Discovery (CAiSMD) 2022” that took place from 09 to 11 March 2022. The first session was held from 08 to 10 March 2021 and drew the attention of many early career scientists from academia and industry. The 23 invited speakers of this year’s workshop also came from academia and industry and 222 registered participants from five continents (Africa, Asia, Europe, South, and North America) took part in the workshop. The workshop highlighted the potential applications of computational methodologies in the search for secondary metabolites or natural products as drug candidates and drug leads. For three days, the participants of this online workshop discussed modern computer-based approaches for exploring NP discovery in the “omics” age. The invited experts gave keynote lectures, trained participants in hands-on sessions, and held round table discussions. These were followed by oral presentations during which much interaction between the speakers and the audience was observed. Selected applicants (early-career scientists) were offered the opportunity to give oral presentations (15 min) upon submission of an abstract. The final program available on the workshop website (https://indiayouth.info/index.php/caismd) comprised three keynote lectures, 14 oral presentations, two round table discussions, and four hands-on sessions. This meeting report also references internet resources for computational biology around secondary metabolites that are of use outside of the workshop areas and will constitute a long-term valuable source for the community.
Viscosity of Wheat Starch Paste Used in Traditional Chinese Conservation Techniques
Authors: Yu Rong , Shen Zhewei , Ye Qianru , Liu Peng 
Published: May 2024

Abstract
In traditional Chinese conservation of historic books and mounted scrolls, the preparation and use of paste is an important process step. The viscosity of the paste is a key factor to consider, taking into account various parameters such as conservation technique, paper condition, or paper thickness. This study aims to determine the viscosity variation of diluted and thick pastes used in traditional Chinese conservation techniques with a rotary viscometer. During conservation treatment, as the number of restored leaves increases, the viscosity of diluted paste tends to increase significantly. The study highlights the different requirements for viscosity depending on its use either in Chinese books or Chinese hanging scrolls and emphasizes the importance of monitoring and adjusting paste viscosity during the conservation process. The use of a rotary viscometer, along with the traditional finger test method, is a significant step forward in improving the accuracy and efficiency of determining paste viscosity.
Analysis of the state of the art technologies for the utilization and processing of associated petroleum gas into valuable chemical products
Authors: Uskov Sergey I. , Potemkin Dmitriy I. , Urlukov Artem S. , Snytnikov Pavel V. 
Published: May 2024

Abstract
The problems concerning the insufficient level of associated petroleum gas (APG) processing are discussed. Various models are proposed for the chemical utilization of APG, including the production of synthesis gas, methanol, dimethyl ether, ammonia, as well as the processes of aromatization of hydrocarbons, etc. The possibility of using APG as a fuel for generating electricity is discussed. Attention is paid to the processes of APG purification from sulfur impurities. Difficulties and solutions to the problems of the energy sector of APG utilization are discussed.
Predicting compressor mass flow rate using various machine learning approaches
Authors: Yazar Isil , Anagun Yildiray , Isik Sahin 
Published: May 2024

Abstract
A major focus of the present study is to construct high-fidelity models for predicting corrected mass flow rates based on the collected compressor map data. Both traditional machine learning research and modern deep learning techniques have been employed to obtain well-fitted regression models of compressor mass flow rate. As traditional machine learning methods, Multiple Linear Regression and Random Forest, are conducted on compressor maps for prediction of corrected mass flow rate. The time series-based deep learning models are able to capture the overall trend of a given input for specific map data. Therefore, a time series-based deep learning technique, namely Gated Recurrent Unit has been employed to improve regression results. Besides, the prediction capabilities of the models, results also show that the proposed models can be used for the development of dynamic aero-thermal mathematical models of gas turbine engines and mass flow rate models created for dynamic compressors in other disciplines.
Referenzprozess für die Beschaffung im Pflegesektor
Authors: Ramm Saskia , Berndt Stephan , Grzona Pierre , Wilsky Philipp 
Published: May 2024

Abstract
In den letzten Jahren wurde die Bedeutung einer krisensicheren Beschaffungsstrategie immer deutlicher. Insbesondere im Pflegesektor traten während der Covid-19-Pandemie erhebliche Versorgungsengpässe auf. Das KISS-Projekt zielt darauf ab, diese Engpässe in zukünftigen Krisen zu mildern. Durch Interviews in Pflegeeinrichtungen wurden die Beschaffungsprozesse in BPMN modelliert. Aus dieser Sammlung wurde der Referenzprozess induktiv abgeleitet. Dieser bildet nun die Grundlage zur Definition von Personas, User Stories und Schnittstellen für die Integration der zu entwickelnden digitalen Services. Zudem können die Ergebnisse dieser Arbeit dazu beitragen, Zeit- und Kosteneinsparungen bei der Umsetzung ähnlicher Projekte im Bereich der Beschaffung solcher Einrichtungen zu erzielen.