bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of clinical and genealogical study in the examination of patients with chronic venous insufficiency
Authors: Kolosovych I. V. , Korolova K. O. , Korolova Z. V. 
Published: February 2025

Objective — to demonstrate the role of heredity in the development of varicose veins using a clinical‑genealogical study, analyze family cases of varicose veins of the lower extremities, determine the type of disease inheritance in the examined patients, and assess the possible outcomes of genetic inheritance for their descendants.
Materials and methods. The study involved 64 patients, mostly women — 52 (81.3%), with different clinical classes of varicose veins. The clinical‑genealogical method of pedigree analysis was used to establish the type of inheritance. We determined the nature of the disease trait (hereditary or non‑hereditary) and the type of inheritance (autosomal dominant, autosomal recessive, or gender‑linked).
Results. Among the 64 examined patients, 28 (43.8%) had familial cases of varicose veins. In our clinical‑genealogical study of the pedigrees of patients with chronic venous insufficiency, we found an autosomal dominant inheritance of this pathology, not linked to gender. Direct inheritance across generations was observed.
Conclusions. The analysis of the pedigrees of patients with varicose veins of the lower extremities and other manifestations of chronic venous insufficiency revealed the familial nature of disease inheritance, characterized by an autosomal dominant inheritance type and a high degree of gene expression. In these families, children are more likely to show signs of the disease. A hereditary predisposition to certain forms of varicose veins has also been noted. Consequently, in individuals with reticular varicose veins, the main veins of the lower extremities exhibited no alterations with age, whereas reticular varicose veins simply increased in prevalence.
Peningkatan Literasi Digital Pelaku Usaha Mikro Kecil dan Menengah Melalui Pelatihan dan Pendampingan pada UMKM Home Industry di Desa Genengan Karanganyar
Authors: Puji Astuti Dewi Saptantinah , Mardayanti Leni 
Published: February 2025

Pengabdian kepada masyarakat ini bertujuan untuk meningkatkan literasi digital para pelaku industri rumah tangga dan Usaha Mikro, Kecil, dan Menengah (UMKM) di Desa Genengan, Kecamatan Jumantono, Kabupaten Karanganyar. Era digitalisasi telah membawa perubahan di berbagai bidang. Saat ini pemanfaatan teknologi informasi menjadi sangat penting bagi pelaku usaha untuk meningkatkan efisiensi dan daya saing. Kegiatan tersebut meliputi sosialisasi mengenai pentingnya pengelolaan keuangan yang baik, pelatihan penggunaan aplikasi akuntansi sederhana, serta pendampingan penerapan teknologi digital. Hasil dari pengabdian ini menunjukkan adanya motivasi dari pelaku usaha untuk memahami penggunaan aplikasi untuk pengelolaan keuangan dan kemampuan pelaku usaha dalam mengelola keuangan secara digital, sehingga berdampak positif pada transparansi dan pengambilan keputusan bisnis. Diharapkan kegiatan ini dapat berkontribusi terhadap pertumbuhan ekonomi lokal dan meningkatkan kesadaran masyarakat akan pentingnya literasi digital.
Development and formation of a modern educational paradigm
Authors: Akimova Olha , Matiiuk Dmytro , Zadvorniak Liudmyla 
Published: February 2025

The article is devoted to the problem of development and formation of the modern educational paradigm. New philosophical grounds for education are highlighted: formation of a new worldview in students; focus on the innovative nature of education; orientation of education towards the future. The modern educational paradigm is defined as a historical category, which is the result of a long-term process of transformation, with the following stages identified: traditional education (until the nineteenth century); education of the industrial period (the nineteenth century); development of humanistic pedagogy (the twentieth century); educational paradigm of the information period (late twentieth - early twenty-first century); modern educational paradigm (the twenty-first century). The following paradigms are characterised: traditionalist-conservative paradigm; technocratic paradigm of education; behaviourist (rationalist) paradigm; humanistic paradigm; «the concept of complete knowledge acquisition». The more modern educational paradigms include: cognitive paradigm, according to which the knowledge of the basics of science is based on thinking; the goal of the learning process is knowledge, skills and abilities, and the source of information is the teacher; personality-oriented paradigm is aimed at solving problems of creative development, activation of independent creative activity through problem-based, developmental, heuristic learning; cultural paradigm, according to which education is interpreted as a socio-cultural phenomenon determined by the level of development of science, education, art, and morality achieved by the society; an innovative paradigm which includes five models: 1) education as the basis for the formation of a scientific worldview, where science is defined as the main value and the ideal is an educated person; 2) education as professionalisation centred on applied sciences, training more specialists with applied knowledge; 3) education as the development of a culture of mental activity, logical thinking, development of a worldview; lifelong education, satisfaction of human needs for lifelong knowledge.
Pengaruh Opini Going Concern dan Financial Distress Terhadap Auditor Switching pada Perusahaan Subsektor Transportasi yang Terdaftar di Bursa Efek Indonesia Periode 2018-2022
Authors: Oktariansyah Oktariansyah , Rohim Abdul , Rosadian Aprizal 
Published: February 2025

ABSTRAK

Penelitian ini bertujuan untuk menguji pengaruh opini going concern dan financial distress terhadap auditor switching yang dilakukan perusahaan secara voluntary baik secara parsial maupun simultan. Penelitian ini termasuk jenis penelitian kuantitatif dengan metode asosiatif kausal yang menghubungkan sebab akibat dari dua atau lebih variabel. Populasi dalam penelitian ini adalah perusahaan subsektor transportasi yang terdaftar di Bursa Efek Indonesia periode 2018-2022 yang berjumlah 51 perusahaan. Teknik pengambilan sampel dalam penelitian ini menggunakan teknik purposive sampling sehingga perusahaan yang menjadi sampel sebanyak 20 perusahaan. Data yang digunakan berupa data sekunder berupa laporan keuangan dan tahunan yang diunduh dari website resmi BEI yaitu www.idx.co.id. Teknik analisa data yang digunakan dalam penelitian ini berupa analisis statistik deskriptif dan analisis regresi logistik. Hasil pengujian menunjukkan bahwa secara parsial opini going concern berpengaruh positif dan signifikan terhadap auditor switching, sedangkan financial distress tidak berpengaruh terhadap auditor switching. Secara simultan opini going concern dan financial distress berpengaruh terhadap auditor switching.
Kata Kunci: Opini Going concern, Financial distress, Auditor switching

ABSTRACT

This study aims to examine the effect of going concern opinion and financial distress on auditor switching by voluntary companies both partially and simultaneously. This research includes a type of quantitative research with a causal associative method that connects the cause and effect of two or more variables. The population in this study were transportation subsector companies listed on the Indonesia Stock Exchange for the period 2018-2022, totaling 51 companies. The sampling technique in this study used purposive sampling technique so that the companies sampled were 20 companies. The data used is secondary data in the form of financial and annual reports downloaded from the official IDX website, namely www.idx.co.id. The data analysis technique used in this study is descriptive statistical analysis and logistic regression analysis. The test results show that partially going concern opinion has a positive and significant effect on auditor switching, while financial distress has no effect on auditor switching. Simultaneously going concern opinion and financial distress affect auditor switching.
Keywords : Going concern Opinion, Financial distress, Auditor switching
Pengaruh E-Service Quality Dan E-Trust Terhadap E-Satisfaction Pada E-Commerce Lazada (Studi Pada Mahasiswa S1 Indralaya Universitas Sriwijaya)
Authors: Abrar Muhammad Iqbal , Yunita Dessy , Mavilinda Hera Febria 
Published: February 2025

ABSTRAK

Penelitian ini bertujuan untuk mengetahui pengaruh e-service quality dan e-trust terhadap e-satisfaction pada e-commerce lazada (studi pada Mahasiswa S1 Indralaya Universitas Sriwijaya). Data yang digunakan ialah data primer yang diperoleh dari hasil penyebaran kuesioner kepada responden. Sampel yang digunakan pada penelitian ini yaitu sebanyak 100 responden dengan kriteria Mahasiswa S1 Indralaya Universitas Sriwijaya yang berumur 17-24 tahun dan pernah bertransaksi di lazada minimal 6 bulan terakhir. Teknik analisis yang digunakan adalah analisis regresi linier berganda. Hasil penelitian menunjukkan bahwa e-service quality dan e-trust berpengaruh positif dan signifikan terhadap e-satisfaction.
Kata Kunci : E-Service Quality, E-Trust, E-Satisfaction.

ABSTRACT

This research aims to determine the effect of e-service quality and e-trust on e-satisfaction in Lazada e-commerce (a study on S1 students of Indralaya, Sriwijaya University). The data used are primary data obtained from questionnaires distributed to respondents. The sample for this research consists of 100 respondents, specifically S1 students of Indralaya, Sriwijaya University, aged 17-24 years who have made transactions on Lazada within the last 6 months. The analysis technique used is multiple linear regression. The results show that e-service quality and e-trust have a positive and significant effect on e-satisfaction.
Keywords : E-Service Quality, E-Trust, E-Satisfaction.
Pengaruh Suistainability Report, Political Connection Dan Firm Size Terhadap Kinerja Keuangan Pada Perusahaan Sektor Energi Yang Terdaftar Di BEI
Authors: Maharani Sarmila , Merina Citra Indah 
Published: February 2025

ABSTRAK

Laporan dari kinerja keuangan dibuat untuk menggambarkan keadaan keuangan perusahaan dimasa lampau untuk melihat keadaan keuangan dimasa yang akan datang. Penelitian ini bertujuan untuk menganalisis pengaruh sustainability report, political connection dan firm size terhadap kinerja keuangan perusahaan energi yang terdaftar di BEI dan dimensi pengungkapan yang memiliki pengaruh paling signifikan. Variabel dependen pada penelitian ini adalah kinerja keuangan yang di hitung menggunakan rasio ROA dan variabel independennya adalah sustainability report, political connectio, dan firm size. Data diproses dengan perhitungan manual dan aplikasi SPSS untuk tahapan uji berupa analisis statistik deskriptif, uji asumsi klasik, analisis regresi linear berganda, dan pengujian hipotesis. Hasil penelitian secara simultanmenunjukan bahwa sustainability report, political connection, dan firm size tidak berpengaruh terhadap kinerja keuangan perusahaan energi di Indonesia. Sedangkan secera persial sustainability report dan political connection tidak berpengaruh terhadap kinerja keuangan, sedangakan firm size secara persial berpengaruh terhadap kinerja keuangan.
Kata Kunci: Kinerja Keuangan, Sustainability Report, Political Connection dan Firm Size.

ABSTRACT

Financial performance reports are made to describe the company's financial condition in the past to see its financial condition in the future. This research aims to analyze the influence of sustainability reports, political connections and firm size on the financial performance of energy companies listed on the IDX and the disclosure dimensions that have the most significant influence. The dependent variable in this research is financial performance which is calculated using the ROA ratio and the independent variables are sustainability report, political connection and firm size. The data was processed using manual calculations and the SPSS application for the test stages in the form of descriptive statistical analysis, classical assumption testing, multiple linear regression analysis, and hypothesis testing. The research results simultaneously show that sustainability reports, political connections, and firm size have no effect on the financial performance of energy companies in Indonesia. Meanwhile, sustainability reports and political connections have no partial effect on financial performance, while firm size has a partial effect on financial performance.
Keywords : Company Financial, Sustainability Report, Political Connection and Firm Size.
Pengaruh Technology Acceptance Model (TAM) Terhadap Intensi Penggunaan Aplikasi Dana Pada Universitas PGRI Palembang
Authors: Kurbani Adie , Syafitri Novri , Akila Akila 
Published: February 2025

ABSTRAK

Penelitian ini bertujuan untuk menguji hipotesis Pengaruh Technology Acceptance Model (Tam) Terhadap Intensi Penggunaan Aplikasi Dana Di Universitas PGRI Palembang. Teknik pengambilan sampel menggunakan rumus slovin dengan jumlah sampel sebanyak 99 responden. Teknik analisis data memakai uji instrumen, uji asumsi klasik, uji multikolinieritas dan uji heteroskedasitas, analisis regresi linier berganda dan analisis koefisiensi determinasi serta uji hipotesis yaitu uji persial dan uji simultan.
Dari uji tersebut uji t variabel perceved easy of use (PEU) (X1) memiliki dampak signifikan terhadap Intensi Penggunaan (Y) pada aplikasi dana di universitas PGRI Palembang dengan nilai signifikan 0,000 < 0,05, variabel perceved usefulness (PU) (X2) berdampak terhadap Intensi Penggunaan (Y) pada aplikasi dana di universitas PGRI Palembang dengan nilai signifikan 0,000 < 0,05, variabel trust (X3) berdampak terhadap Intensi Penggunaan (Y) pada aplikasi dana di universitas PGRI Palembang dengan nilai signifikan 0,000 > 0,05, dan hasil uji F secara simultan terdapat nilai signifikan 0,000 < 0,05 dapat disimpulkan bahwa ada dampak yang signifikan secara simultan perceved easy of use (X1), perceved usefulness (X2) dan trust (X3) terhadap Intensi Penggunaan (Y) pada aplikasi dana di universitas PGRI Palembang.
Kata Kunci: perceved easy of use, perceved usefulness, trust dan intensi penggunaan.

ABSTRACT

This research aims to test the hypothesis of the influence of the Technology Acceptance Model (Tam) on Intentions to Use Fund Applications at PGRI University Palembang. The sampling technique used the Slovin formula with a sample size of 99 respondents. Data analysis techniques use instrument tests, namely validity and reliability, classical assumption tests, namely normality tests, multicollinearity tests and heteroscedasticity tests, multiple linear regression analysis, namely correlation coefficient analysis and coefficient of determination analysis and hypothesis tests, namely t tests and f tests. The test results partially concluded that the perceived ease of use (PEU) variable (X1) had a significant influence on the Intention to Use (Y) in fund applications at PGRI Palembang University with a significant value of 00,000 < 0.05, the perceived usefulness (PU) variable (X2) effect on Intention to Use (Y) on fund applications at PGRI Palembang university with a significant value of 0.000 < 0.05, the trust variable (X3) effect on Intention to Use (Y) on fund applications at PGRI Palembang university with a significant value of 0.000 < 0 .05, and the results of the F test simultaneously obtained a significant value of 0.000 < 0.05. It can be concluded that there is a significant influence simultaneously perceived ease of use (X1), perceived usefulness (X2) and trust (X3) on Intention to Use (Y) on funding applications at PGRI Palembang University.
Keywords : perceived ease of use, perceived usefulness, trust and intention to use
OPTIMALISASI RUTE KENDARAAN MENGGUNAKAN METODE SAVING MATRIX SEBAGAI PENENTUAN RUTE DISTIBUSI DARAH DI UTD PMI KOTA PEKANBARU
Authors: Mandagiri Dwi Rahmadhani , Nazzaruddin  , Muhammad Nur  
Published: February 2025

Penelitian ini dilakukan di Unit Transfusi Darah Palang Merah Indonesia Kota Pekanbaru. UTD PMI tersebut merupakan unit pelayanan kesehatan yang terdiri dari seragkai kegiatan, salah satunya adalah pendonoran darah. Unit Transfusi darah berfunsi sebagai fasilitas pelayanan donor darah, menyediakan darah dan mendistibusikan darah. UTD PMI Kota Pekanbaru melayani berbagai transaksi permasalahan darah untuk kelangsungan hidup masyarakat serta mendistribusikan darah ke berbagai Rumah Sakit atau Bank Darah Rumah sakit Kota Pekanbaru. Dengan dilakukannya distribusi darah ke pihak rumah sakit, UTD PMI dapat menyediakan mobil dengan kedap udara agara suhu yang ada didalam ruangan mobil tidak berkurang dari sebelumnya saat pengantaran darah. Tujuan penelitian ini Untuk menentukan alur terbaik untuk pendistribusian darah agar menjadi optimal dan dapat meminimalisir jarak tempuh distribusi darah dari Unit Transfusi Darah Palang Merah Indonesia (UTD PMI) ke Rumah Sakit Kota Pekanbaru menggunakan Saving Matrix. Metode saving matrix adalah suatu metode yang digunakan untuk menyelesaikan masalah dalam transportasi untuk menentukan rute distribusi produk agar meminimalisasi biaya transportasi. Metode ini dipilih karena kemampuannya dalam meminimalkan jarak tempuh dan waktu distribusi, yang sangat penting untuk menjaga kualitas darah. Data yang digunakan mencakup informasi lokasi UTD dan rumah sakit di Pekanbaru. Hasil penelitian menunjukkan bahwa penerapan metode Saving Matrix dapat mengurangi total jarak tempuh distribusi darah hingga 20% dan meningkatkan efisiensi waktu pengiriman. Penelitian ini diharapkan dapat memberikan rekomendasi bagi UTD PMI dalam merancang rute distribusi yang lebih optimal, sehingga meningkatkan pelayanan kesehatan masyarakat.
Propuesta de requisitos mínimos de accesibilidad para los complejos comerciales de la empresa comercial Caracol S.A en la Habana
Authors: Romaní Bendig Beatriz , Reyes Rodríguez Neysa , Espinosa Manfugá Julia Ma , Velasteguí López Luis Efraín 
Published: February 2025

Introducción. La accesibilidad turística busca integrar a las personas con discapacidad a los medios físicos y sociales por medio de la eliminación o disminución de las barreras sociales, culturales, estructurales y físicas. La OMT apuesta por un turismo accesible para todos. Para la Dirección de Calidad y Operaciones del Mintur es una prioridad que se garanticen los requisitos de accesibilidad en el destino; este estudio en particular aborda esta temática en el contexto de los complejos comerciales del sector en La Habana. Objetivo. Proponer requisitos mínimos de accesibilidad para los complejos comerciales de la Empresa Comercial Caracol S.A, en La Habana. Metodología. Se realizó una entrevista semiestructurada a las especialistas de calidad de la Empresa Comercial Caracol S.A y de sus cinco sucursales en La Habana. También se aplicó otra entrevista a los presidentes de la Red Iberoamericana y de la Cubana de Turismo Accesible, así como a los de la Asociación Nacional de Ciegos, Asociación Nacional de Sordos de Cuba y de la Asociación Cubana de Limitados Físico – Motores. Se llevó a cabo una revisión de la literatura especializada para obtener información sobre los requisitos que los complejos comerciales tienen que cumplir para ser accesibles. El procesamiento de los datos se realizó a partir de la estadística descriptiva, así como el diagrama de Pareto mediante el Microsoft Excel para Windows, versión Excel 2019 (17.0). La validación de la propuesta se realizó por un grupo de expertos seleccionados, a través del método ANOCHI. Resultados. Los resultados de la investigación permitieron constatar que los complejos comerciales de la Empresa Comercial Caracol S.A en La Habana no son accesibles y que los retos vitales para que los complejos comerciales lleguen a ser accesibles son: el personal capacitado, concientización del personal, y reestructuración de la infraestructura. Conclusión. Se elaboró la propuesta de requisitos mínimos de accesibilidad, la cual fue estructurada en requisitos generales y específicos, los que incluyen un total de 14 apartados, así como la lista de chequeo, comprobándose la validez y fiabilidad de la propuesta para los complejos comerciales de la Empresa Comercial Caracol S.A en La Habana. Área de estudio general: (Turismo). Área de estudio específica: (Accesibilidad turística). Tipo de estudio: Artículos originales / Original articles,
Gut microbiota dysfunction in Crohn’s disease
Authors: Buffet-Bataillon Sylvie , Durão Gabriela , Le Huërou-Luron Isabelle , Rué Olivier , Le Cunff Yann , Cattoir Vincent , Bouguen Guillaume 
Published: February 2025

IntroductionCrohn’s disease (CD) results from alterations in the gut microbiota and the immune system. However, the exact metabolic dysfunctions of the gut microbiota during CD are still unclear. Here, we investigated metagenomic functions using PICRUSt2 during the course of CD to better understand microbiota-related disease mechanisms and provide new insights for novel therapeutic strategies.MethodsWe performed 16S rRNA-based microbial profiling of 567 faecal samples collected from a cohort of 383 CD patients, including 291 remissions (CR), 177 mild-moderate (CM) and 99 severe (CS) disease states. Gene and pathway composition was assessed using PICRUSt2 analyses of 16S data.ResultsAs expected, changes in alpha and beta diversity, in interaction networks and increases in Proteobacteria abundance were associated with disease severity. However, microbial function was more consistently disrupted than composition from CR, to CM and then to CS. Major shifts in oxidative stress pathways and reduced carbohydrate and amino acid metabolism in favour of nutrient transport were identified in CS compared to CR. Virulence factors involved in host invasion, host evasion and inflammation were also increased in CS.ConclusionsThis functional metagenomic information provides new insights into community-wide microbial processes and pathways associated with CD pathogenesis. This study paves the way for new advanced strategies to rebalance gut microbiota and/or eliminate oxidative stress, and biofilm to downregulate gut inflammation.
A diverse rotation of corn-soybean-winter wheat/double crop soybean with cereal rye after corn reduces tile nitrate loss
Authors: Gentry Lowell E. , Mitchell Corey A. , Green John M. , Guacho Carlos , Miller Eric , Schaefer Dan , Vasquez Annette K. , Yu Zhongjie 
Published: February 2025

Artificial drainage via subterranean drainage pipes called tiles transport nitrate from fields to streams, impairing downstream surface waters. Increased crop rotational diversity may conserve nitrogen, support greater system resiliency, and reduce tile nitrate loss. This 9-year study compares tile nitrate loss under a 3-year rotation of corn-soybean-winter wheat/double crop soybean plus cereal rye after corn versus a conventionally managed 2-year corn-soybean rotation. Tile flow and tile nitrate concentration were measured from 2015 through 2023 to determine annual flow weighted mean concentrations and loads of tile nitrate. Cereal rye following corn greatly reduced annual tile nitrate; however, more than 6 Mg ha−1 of above ground biomass may have decreased soybean yield. Winter wheat was efficient at using split-applied fertilizer nitrogen (N) as annual tile nitrate concentrations were reduced similar to cereal rye. Double crop soybean after winter wheat may be the most productive phase of the rotation; however, an early killing freeze greatly reduced soybean yield and increased tile nitrate loss. Interestingly, the subsequent corn crop may have benefitted from this unexpected N source. Overall, tile nitrate loss was approximately 50% less in the diverse 3-year rotational system, suggesting that a more diverse rotational system is efficient at retaining N, conserving nitrogen in the field, and reducing N loss to surface water. This study demonstrated proof of concept that a more diverse crop rotation can reduce tile nitrate loss from fields to streams, while maintaining crop productivity.