bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intravitreal MPTP drives retinal ganglion cell loss with oral nicotinamide treatment providing robust neuroprotection
Authors: Rombaut Anne , Jovancevic Danica , Wong Raymond Ching-Bong , Nicol Alan , Brautaset Rune , Finkelstein David I. , Nguyen Christine T. O. , Tribble James R. , Williams Pete A. 
Published: May 2024

AbstractNeurodegenerative diseases have common underlying pathological mechanisms including progressive neuronal dysfunction, axonal and dendritic retraction, and mitochondrial dysfunction resulting in neuronal death. The retina is often affected in common neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease. Studies have demonstrated that the retina in patients with Parkinson’s disease undergoes changes that parallel the dysfunction in the brain. These changes classically include decreased levels of dopamine, accumulation of alpha-synuclein in the brain and retina, and death of dopaminergic nigral neurons and retinal amacrine cells leading to gross neuronal loss. Exploring this disease's retinal phenotype and vision-related symptoms is an important window for elucidating its pathophysiology and progression, and identifying novel ways to diagnose and treat Parkinson’s disease. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is commonly used to model Parkinson’s disease in animal models. MPTP is a neurotoxin converted to its toxic form by astrocytes, transported to neurons through the dopamine transporter, where it causes mitochondrial Complex I inhibition and neuron degeneration. Systemic administration of MPTP induces retinal changes in different animal models. In this study, we assessed the effects of MPTP on the retina directly via intravitreal injection in mice (5 mg/mL and 50 mg/mL to 7, 14 and 21 days post-injection). MPTP treatment induced the reduction of retinal ganglion cells—a sensitive neuron in the retina—at all time points investigated. This occurred without a concomitant loss of dopaminergic amacrine cells or neuroinflammation at any of the time points or concentrations tested. The observed neurodegeneration which initially affected retinal ganglion cells indicated that this method of MPTP administration could yield a fast and straightforward model of retinal ganglion cell neurodegeneration. To assess whether this model could be amenable to neuroprotection, mice were treated orally with nicotinamide (a nicotinamide adenine dinucleotide precursor) which has been demonstrated to be neuroprotective in several retinal ganglion cell injury models. Nicotinamide was strongly protective following intravitreal MPTP administration, further supporting intravitreal MPTP use as a model of retinal ganglion cell injury. As such, this model could be utilized for testing neuroprotective treatments in the context of Parkinson’s disease and retinal ganglion cell injury.
Method for selecting viewpoints of architectural heritage landscapes
Authors: Hu Yungang , Feng Yutang , Zhao Ran , Wu Yuhua , Nie Pinjun 
Published: May 2024

Abstract
The selection of viewpoints is a crucial aspect in conducting visual impact assessments of architectural heritage. To address this issue, a quantitative viewpoint selection method based on GIS spatial analysis is proposed. The first step involves defining the factors that influence the selection of viewpoints for architectural heritage. Next, the city’s historical architectural areas are divided into units based on courtyards. Subsequently, a candidate set of viewpoints is constructed by extracting the skeleton lines and characteristic points of sub-regions. Finally, following the principles of viewpoint selection, the method achieves the selection of viewpoints for the visual impact assessment of architectural heritage. The Forbidden City is chosen as the practical area for implementation, and the results demonstrate that the viewshed coverage range in the architectural heritage area is as high as 96%. It represents that this approach for visual impact assessments of architectural heritage is more grounded.
Insights into fermentation with lactic acid bacteria on the flavonoids biotransformation of alfalfa silage
Authors: Gao Yu , Zhou Hongzhang , Wang Yuan , Nussio Luiz Gustavo , Yang Fuyu , Ni Kuikui 
Published: May 2024

Abstract
Background
Oxidative stress is currently one of the main threats to animal health, and flavonoids in forage have good antioxidant activity. However, the impact of fermentation on flavonoids and their antioxidant activity in forage is still unclear. This study aims to investigate the effect of lactic acid bacteria inoculation on the biological transformation of flavonoids in alfalfa silage fermentation and its relationship with antioxidant activity.

Results
Compared with the raw materials, silage fermentation can increase the total flavonoid content of alfalfa. The addition of Pediococcus pentosaceus (CP115739.1) and Lactiplantibacillus plantarum (CP115741.1) can significantly increase the total flavonoid content in alfalfa silage (P < 0.05). The addition of lactic acid bacteria significantly improved the antioxidant capacity of alfalfa silage (P < 0.05). Pearson correlation analysis showed a significant correlation between total flavonoids and DPPH (R = 0.62, P < 0.05), and a highly significant correlation between total flavonoids and FRAP (R = 0.70, P < 0.01). Compared with natural silage fermentation, the addition of lactic acid bacteria leads to changes in the biological transformation process of flavonoids in alfalfa. Its unique products, 3,7,4′-trioxyflavonoids, as well as acacetin and taxifolin 7-O-rhamnoside, are significantly positively correlated with antioxidant activity.

Conclusions
Silage fermentation contributes to the transformation of flavonoids, and inoculation with certain lactic acid bacteria can increase the content of flavonoids (including apigenin, luteolin, and other free flavonoids). It is worth noting that after fermentation, the antioxidant capacity of alfalfa is significantly improved, which may be attributed to the biotransformation of flavonoids related to acacetin, 3,7,4′-trihydroxyflavonoids, and taxifolin 7-O-rhamnoside. This study provides a potential pathway for obtaining value-added silage fermentation products by selecting specific lactic acid bacteria inoculants.

Graphical Abstract
Potential Moderators of the Effects of Blood Flow Restriction Training on Muscle Strength and Hypertrophy: A Meta-analysis Based on a Comparison with High-Load Resistance Training
Authors: Geng Yu , Wu Xueping , Zhang Yong , Zhang Meng 
Published: May 2024

AbstractBackgroundWhile it has been examined whether there are similar magnitudes of muscle strength and hypertrophy adaptations between low-load resistance training combined with blood-flow restriction training (BFR-RT) and high-load resistance training (HL-RT), some important potential moderators (e.g., age, sex, upper and lower limbs, frequency and duration etc.) have yet to be analyzed further. Furthermore, training status, specificity of muscle strength tests (dynamic versus isometric or isokinetic) and specificity of muscle mass assessments (locations of muscle hypertrophy assessments) seem to exhibit different effects on the results of the analysis. The role of these influencing factors, therefore, remains to be elucidated.ObjectivesThe aim of this meta-analysis was to compare the effects of BFR- versus HL-RT on muscle adaptations, when considering the influence of population characteristics (training status, sex and age), protocol characteristics (upper or lower limbs, duration and frequency) and test specificity.MethodsStudies were identified through database searches based on the following inclusion criteria: (1) pre- and post-training assessment of muscular strength; (2) pre- and post-training assessment of muscular hypertrophy; (3) comparison of BFR-RT vs. HL-RT; (4) score ≥ 4 on PEDro scale; (5) means and standard deviations (or standard errors) are reported or allow estimation from graphs. In cases where the fifth criterion was not met, the data were requested directly from the authors.ResultsThe main finding of the present study was that training status was an important influencing factor in the effects of BFR-RT. The trained individuals may gain greater muscle strength and hypertrophy with BFR-RT as compared to HL-RT. However, the results showed that the untrained individuals experienced similar muscle mass gains and superior muscle strength gains in with HL-RT compared to BFR-RT.ConclusionCompared to HL-RT, training status is an important factor influencing the effects of the BFR-RT, in which trained can obtain greater muscle strength and hypertrophy gains in BFR-RT, while untrained individuals can obtain greater strength gains and similar hypertrophy in HL-RT.
Electricity mix from renewable energies can avoid further fragmentation of African rivers
Authors: Peters Rebecca , Berlekamp Jürgen , Tockner Klement , Zarfl Christiane 
Published: May 2024

AbstractIn Africa, mitigating climate change in a context of a growing human population and developing economies requires a bold transition to renewable energy (RE) resources. Declining costs for solar photovoltaics (by 90% between 2009 and 2023) and wind turbines (by 57% between 2010 and 2023) fuelled their construction, and hybrid forms such as floating photovoltaics (FPV) on existing hydropower reservoirs are increasingly being explored. Nevertheless, 65% of the proposed RE capacity in Africa remains hydropower, despite confirmed ecological, socioeconomic, and political ramifications on different spatiotemporal scales. The 673 proposed hydropower plants (HPPs) would increasingly affect river systems and threaten their biodiversity. While there is clear evidence that a transition to RE in Africa is technically feasible, there is a lack of spatially explicit studies on how this transition could be implemented. Hence, the aim of the present study is to explore options for an RE mix that avoids additional hydropower construction and, therefore, further river fragmentation. Attribute data of the open-accessible Renewable Power Plant Database (RePP Africa) were analysed to assess the amount of lost capacity due to operation stops. Geospatial analyses of solar irradiation and existing reservoir data were used to derive the potential for FPV. The degree of possible replacement of future hydropower was assessed under consideration of economically feasible wind and solar photovoltaic (PV) potential. To enhance electricity generation from existing HPPs, efficient and sustainable renewable power plant planning must integrate the risk of failure, as it has diminished the available capacity in the past up to 24%. Our findings further reveal that 25 African countries could replace the proposed hydropower development by FPV covering less than 25% of the surface area of their existing hydropower reservoirs. All 36 African countries could replace proposed hydroelectricity generation by fully exploiting feasible onshore wind and solar PV potential with a mean surplus of 371 TWh per year. In summary, our findings provide scientific evidence to support policy discussions on the potential electricity gains from (1) minimizing plant failure, (2) installing FPV as a co-use option, and (3) exploiting wind and solar resources. This study provides quantitative, data-based, and spatially explicit scenarios on the implementation of an RE mix that could relieve the dam building pressure on African rivers.
Circadian temperature rhythm in breeding sows: differences between days in oestrus and anoestrus after weaning
Authors: Sánchez-Giménez P. , Martínez-Nicolas A. , Madrid J. A. , Fernández R. , Martínez-Alarcón L. , Murciano F. , Muñoz A. , Ramis G. 
Published: May 2024

AbstractBackgroundMammals are subject to circadian rhythms for the control of various physiological events. One of the parameters known to be subject to variations throughout the day is body temperature, which is also subject to influences such as environmental temperature. However, there are not many studies on these rhythms in breeding sows. The aim of this study was to determine the circadian parameters for body temperature in post-weaning sows during oestrus period, throughout the seasons in a warm climate.ResultsDifferences were observed in inter-daily stability, intra-daily fragmentation and cycle length comparing the summer sows with the other seasons. Differences were also observed in the period that the sows were in oestrus compared to the non-oestrus period for intra-daily fragmentation, with these differences being more important in the warm seasons compared to the cold seasons. The parameters normalised by COSINOR also showed significant differences when comparing seasons, especially in the acrophase of the temperature maximum. Another significant finding was an increase in vaginal temperature during oestrus in sows monitored in summer compared to the other seasons. Correlations between body, vaginal and environmental temperature were observed.ConclusionThere is a seasonal influence on the circadian rhythm of temperature and summer is clearly the season with the greatest differences in circadian parameters when compared to the other seasons. The extreme summer conditions seem to definitely influence this rhythm and make the body and vaginal temperature of the sows different from the rest of the year. The increase in period robustness in both body and vaginal temperature during the days when sows are in oestrus could be related to the hormonal events of oestrus and ovulation and seems to be independent of weather since it occurs in all controlled seasons. However, this robustness is significantly higher in summer than in the other seasons both in the oestrus period and on days when sows are not in oestrus.
Price dynamics and volatility jumps in bitcoin options
Authors: Chen Kuo Shing , Yang J. Jimmy 
Published: May 2024

AbstractIn the FinTech era, we contribute to the literature by studying the pricing of Bitcoin options, which is timely and important given that both Nasdaq and the CME Group have started to launch a variety of Bitcoin derivatives. We find pricing errors in the presence of market smiles in Bitcoin options, especially for short-maturity ones. Long-maturity options display more of a “smirk” than a smile. Additionally, the ARJI-EGARCH model provides a better overall fit for the pricing of Bitcoin options than the other ARJI-GARCH type models. We also demonstrate that the ARJI-GARCH model can provide more precise pricing of Bitcoin and its options than the SVCJ model in term of the goodness-of-fit in forecasting. Allowing for jumps is crucial for modeling Bitcoin options as we find evidence of time-varying jumps. Our empirical results demonstrate that the realized jump variation can describe the volatility behavior and capture the jump risk dynamics in Bitcoin and its options.
Role of Von Willebrand factor level as a biomarker in acute ischemic stroke
Authors: Sabbah Asmaa Sayed , Elkattan Manal Mahmoud , Labib Dalia Mohammed , Hamdy Mona Salah Eldin , Wahdan Nancy Samir , Aboulfotoh Al-shaimaa Mahmoud 
Published: May 2024

Abstract
Background
Von Willebrand factor (VWF) is a large, multimeric glycoprotein that plays a role in thrombus formation; it is also an important mediator of inflammation. Our study aims to determine the association of VWF plasma level and acute ischemic stroke and determine plasma level of VWF in different subtypes of acute ischemic stroke. This case–control study was conducted on 90 subjects: 30 acute ischemic atherosclerotic stroke patients, 30 acute cardioembolic stroke patients and 30 healthy age and sex-matched control subjects. Stroke patients were recruited within the first week of stroke onset with an age range from 18 to 75 years. All subjects underwent complete neurological examination, duplex ultrasonography (U/S), CT brain, routine laboratory work-up and serum level of VWF.

Results
VWF serum levels were significantly elevated in patients of acute ischemic stroke, compared to control subjects. Higher plasma levels of VWF were observed in patients with acute ischemic atherosclerotic stroke.

Conclusion
Serum level of VWF can be used as a marker for acute ischemic stroke, especially the atherosclerotic subtype.
Dynamic channelwise functional-connectivity states extracted from resting-state EEG signals of patients with Parkinson’s disease
Authors: Ding Hao , Weng Xinmeng , Xu Minghuan , Shen Jian , Wu Zhanxiong 
Published: May 2024

Abstract
Background
Parkinson’s disease (PD) is a progressive neurodegenerative disease that usually happens to elderly people, with a wide range of motor and dementia symptoms. An objective and convenient biomarker for PD detection is extremely valuable, especially one that could be acquired non-invasively and low-costly. To this end, this study used resting-state scalp electroencephalography (EEG) signals to explore dynamic functional-connectivity (dFC) states between each pair of EEG recording channels, without source localization.

Methods
dFC refers to synchronization patterns over time between each pair of EEG channels. First, five frequency bands were extracted from EEG signals with fourth-order Butterworth bandpass filter, including delta (0.5–4 Hz), theta (4–8 Hz), alpha (8–13 Hz), beta (8–30 Hz) and gamma (30–50 Hz). Then, after non-random joint fluctuation was measured with weighted symbolic mutual information (wSMI) algorithm, whole-brain dynamic channelwise dFC states were estimated, and classified with k-means clustering. At last, FC state occurrences were calculated, and ANOVA analyses were performed for each state. Two open-source resting-state EEG data sets (https://doi.org/10.18112/openneuro.ds002778.v1.0.4: 32 channels, 16 health controls and 15 PD subjects. https://doi.org/10.18112/openneuro.ds003490.v1.1.0: 64 channels, 25 health controls and 25 PD subjects) were used to test our methods.

Results
Significant changes in proportions of various dFC states within beta frequency-band were consistently observed in these both data sets (p value < 0.05).

Conclusions
Our findings suggest that channelwise dFC states within beta frequency-band directly extracted from resting-state scalp–EEG recordings could potentially serve as a biomarker of PD.
Guiding lights in the early postoperative computed tomography following cranial surgery for traumatic brain injury patients
Authors: Elkholy Hany , Elnoamany Hossam , Dorrah Mohamed 
Published: May 2024

Abstract
Background
Computed tomography (CT) can be a substantial source of guiding lights during the early postoperative hours in traumatic brain injury (TBI) patients. However, controversy still exists regarding: What is the appropriate time for the first postoperative CT? And what are the guiding lights that can be gained from an early follow-up CT? Therefore, our objective was to reach more clear answers for these questions and to design a simple algorithm for the follow-up of TBI patients during the first 24 h after cranial surgery.

Methods
This is a retrospective study included 164 TBI patients who were surgically treated for various traumatic cranial and/or intracranial lesions in our neurosurgery department from January 2022 to April 2023. Pre- and postoperative clinical and radiological data of these patients were collected and analyzed.

Results
The mean age was (23.46 ± 15.126) years. The mean glasgow coma scale (GCS) on presentation was (11.62 ± 3.004). 51.2% of patients had their first follow-up CT done within the first postoperative hour (0–1 h). Postoperative remarkable CT findings were detected in 39 patients (23.8%), with 13 cases (33.3%) of them required re-surgery. 69.2% of the postoperative remarkable findings were recognized in the first hour CT (P = 0.025). Acute subdural hematoma was the only significant primary lesion associated with the need for re-surgery (P = 0.015). Postoperative development of remarkable CT findings was significantly (P < 0.001) associated with increased possibility of re-surgery, high mortality rate, prolonged hospital stay and poor outcome.

Conclusions
Immediate (0–1 h) follow-up CT brain can be more lucrative in the early postoperative assessment for TBI patients. The first hour CT can provide distinct guiding lights of significant value for the subsequent postoperative management and prediction of patients' clinical course and discharge outcome.
Safety and feasibility of mini-open Wiltse approach in posterolateral lumbar stabilization and fusion: intra- and post-operative evaluation
Authors: Elkholy Hany , Elnoamany Hossam , Hussein Mohamed Adel 
Published: May 2024

Abstract
Background
Expected operative challenges in minimally invasive spine surgeries as a result of restricted surgical field, unfamiliarity with surgical approaches and fear of complications are behind the preference of using traditional "open" spine surgery.

Objectives
To evaluate the safety and feasibility of mini-open Wiltse approach in comparison with the conventional midline approach for posterolateral lumbar stabilization and fusion.

Patients and methods
A retrospective comparative study conducted on 49 patients with low grade single level lumbar spondylolithesis who were surgically treated in our Department between May 2020 and May 2022. Patients who were surgically treated with traditional midline approach were included in group (A) and patients in whom the mini-open Wiltse approach was used, were assigned to group (B). The two groups were compared regarding various intra and postoperative parameters.

Results
Group (A) included 27 patients (55.1%) operated upon with the classic midline approach and 22 patients (44.9%) were surgically treated using the Wiltse approach (group B). The mean patients' age (50.43 ± 5.538) years and L4-5 was the most commonly affected level (71.4%). The intra-operative parameters (operation time, blood loss and fluoroscopy time) showed significant lower results (P < 0.001) among patients of group (B). No cases in the group (B) required blood transfusion versus 5 cases in group (A) (P = 0.033). Postoperatively, the Oswestry Disability Index (ODI) and Visual analogue scale (VAS) scores were significantly improved in each group in comparison to the preoperative scores (P < 0.001). However, after 3 months the ODI score in group (B) was superior to that in group (A) (P = 0.045) and postoperative VAS score in group (B) was significantly improved compared to that in group (A) at discharge (P = 0.016), and also after 1 and 3 months (P < 0.001). Patients operated with Wiltse approach had a shorter duration of hospital stay but the difference was not statistically significant (P = 0.090).

Conclusions
Because of minimal trauma to the muscles and soft tissues, the mini-open Wiltse approach can be faster, safer and requires less recovery time as opposed to the classic midline approach.
Inflammatory fibroid polyp– a rare aetiology for adult ileocolic intussusception
Authors: Toro Tole David , Sufyan Wajiha , Bade Kim 
Published: May 2024

AbstractWe report a case of an adult ileocolic intussusception secondary to an inflammatory fibroid polyp (IFP), a rare and unexpected association between a surgical condition, and an underlying histopathological process. Intussusception is an uncommon surgical diagnosis in adults, and an IFP is rare mesenchymal tumour. Surgical intervention of the intussusception in an adult patient, given the uncertain aetiology of the lead point, is recommended as gold standard.