bluuebunny/crossref_metadata_2025_split huggingface dataset:
Homoeopathic treatment for chronic cough – a multicentric, prospective, exploratory trial
Authors: Kaur Harleen , Rutten Lex , Lamba Chetna Deep , Rao Shalini , Bajpai Anurag , Sachdeva Jyoti , Raizada Sonia , Choudhury Sujata , Shinde Vaishali , ER Vinitha , Kundu Chittarajan , Pal Partha Pratim , Kiranmayee Rompicherla GR , Sahoo Amulya Ratna , Rajashekhar Bodankar , Shil Ratan Chandra , Mahajan Nidhi , Khurana Anil , Oberai Praveen , Manchanda Raj K. 
Published: May 2024

Context
Cough is a major symptom of respiratory and some non-respiratory ailments for which patients usually seek primary medical care. Homoeopathy is frequently used for treatment of chronic cough.
Objective
This study aims to assess whether homoeopathy is useful for treating chronic cough resulting from Upper airway cough syndrome (UACS), Asthma and related syndromes, or Gastroesophageal reflux disease (GERD).
Study Design
A multi‑centre, exploratory, prospective trial.
Study setting
The study was conducted in the outpatient departments of 10 centres of CCRH, India from May 2018 – June 2020.
Patients
Patients of any gender, between 7-65 years of age, presenting with cough lasting >8 weeks, were enrolled.
Main Outcome Measure(s)
Cough Severity Index (CSI) and EQ-5D-5L scales were used to analyse the outcomes.
Results
Out of 2397 patients screened only 706 cases, with minimum four follow ups were analysed, on modified Intention to Treat (mITT) basis. CSI and EQ-5D-5L scores were used to analyse the outcomes of the study. The mean of the CSI score at baseline was 19.09 whereas it reduced to 3.89 in the eighth follow-up with p value <0.01. The mean of the EQ-5D-5L score at baseline was 50.59 which increased to 73.79 in the last follow-up, with p-value<0.05. Phosphorus, Arsenic album, Pulsatilla, Sulphur, Lycopodium and Silica were found to be the most frequently prescribed medicines.
The effect of Marrubium vulgare L extracts against urinary tract bacteria pathogens infection in Alassaba'a hospital, of west Tripoli
Authors: Abdusalam Khaled , Ehmeda Ahmed , Joumh Duha , Allishani Ghalih , Abozakhar Mareen 
Published: May 2024

Urinary tract infections (UTIs) are common infections that happen by many types of bacteria. Some of bacteria have resistance against several types of antibiotics. Many medicinal plants used as an alternative treatment around the world. Marrubium vulgare L has been reported to exhibit several biological properties. Thus, the aim of current study is estimating antimicrobial activities of M. vulgare against Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus, which caused urinary tract infections, isolated from infected patients. In the results, the growth of all tested bacteria was inhibited strongly by methanol extract at 1.0% (w/v) with inhibition zones 11.00, 11.00 and 15.50 mm against E. coli, k. pneumoniae and S. aureus respectively. Besides, Minimum Inhibitory Concentration (MIC) values were ranged between 0.625 to 1.25 mg/mL. While, Minimum Bactericidal Concentration (MBC) values were ranging between 1.25 to 2.5 mg/mL. On the other hand, hexane extract also was inhibited the growth of E. coli, k. pneumoniae and S. aureus with inhibition zones 10.00, 11.00 and 12.50 mm respectively. In addition, MIC values ranging 2.5 mg/mL, while MBC values of 5 mg/mL against all bacteria. In conclusion, the methanol extract of M. vulgare had a strongly effects on all bacteria compared to hexane extract, thus it can be developed as anti-bacterial agent.
REPRODUCTIVE HEALTH CARE OF CHILDREN AND ADOLESCENTS: PAST AND PRESENT
Authors: Lukasheva О. V. , Makarov К. Yu. , Bortsov V. A. , Sokolova Т. М. , Kuleshov V. М. , Kiseleva Т. V. , Piven L. А. , Yuryeva Т. А. 
Published: May 2024

Тhe scientific review of the historical development of reproductive health care for children and adolescents from the 19th century to the present reflects the evolution of approaches and the significance of research in modern healthcare.The aim of the study was to study the history of the formation of the reproductive health system for children and adolescents.Materials and methods: The study used information bases: PubMed, PubMed Central, Scopus, MEDLINE, ScienceDirect, Cochrane Library, eLibrary for the period from 1954 to February 2024. For the specified keywords: “protection of reproductive health of adolescents”, “reproductive health of adolescent girls”, “organization of adolescent health”, “reproductive health”, “preventive work”, 40 publications were found in search engines that fully correspond to the stated problem. The formation of the adolescent health care system in Russia since the early Soviet period is examined, highlighting the features of organizing preventive and medical services. The development of medical care in the post-war period is analyzed, particularly in the context of reproductive health, including the establishment of specialized clinics for children and adolescents, and strengths and weaknesses of healthcare organization are described. Additionally, the current influence of global reproductive health strategies on medical service policy in Russia is discussed. The role of outpatient and obstetric-gynecological care in providing medical-preventive assistance is emphasized, highlighting the importance of preventive work and information-educational activities. A comprehensive approach to reproductive health, including social and psychological aspects, and the significance of scientific research and initiatives in this area are examined.
THE ROLE OF INDIVIDUAL NEUROINFLAMMATION MOLECULES IN PATHOGENESIS ISCHEMIC STROKE. PART I
Authors: Ma-Van-de А. Yu. , Fefelova Е. V. , Shirshov Yu. A. 
Published: May 2024

Ischemic stroke is an acute, severe vascular pathology of the brain, accompanied by general cerebral and focal neurological symptoms. The occurrence of the disease is based on arterial thrombosis, leading to the formation of a focus of infarction of brain tissue. In most cases, after an acute cerebral accident, persistent neurological deficits persist in the form of motor, cognitive and other disorders. Cerebral infarction is a multifactorial disease with a complex multicascade pathogenesis. The severity of the disease, the speed of patient recovery and outcome do not always correlate with their age and the presence of underlying pathology. Therefore, at the moment, there is a certain interest in an in-depth study of the pathological processes that occur directly at the site of cerebral infarction and in the penumbra zone (ischemic penumbra). It is possible that a more detailed understanding of the ongoing pathological processes will allow us to further achieve better results in the process of treatment and recovery of patients.The presented literature review highlights current data on the main pathological processes that occur during ischemic stroke. The role of microglia as the main regulator of the processes of inflammation, immunosuppression, degeneration and repair of nervous tissue is considered.
PROGNOSTIC FACTORS FOR THE DEVELOPMENT OF OSTEOPOROTIC FRACTURES IN WOMEN OF DIFFERENT ETHNIC GROUPS OVER 50 YEARS OLD RESIDING IN THE TRANSBAIKAL REGION
Authors: Verkhoturova S. V. , Gorbunov V. V. , Tsarenok S. Y. , Aksenova Т. А. 
Published: May 2024

The aim of the research. To study prognostically unfavorable risk factors of the occurrence osteoporotic fractures in women over 50 years old in Trans-Baikal Region.Materials and methods. 121 women with OP (67 Russian and 54 Buryat nationalities, average age 63.5 years) and 145 healthy women of the same age were examined. The genetic polymorphisms VDR, LCT and COL1A1 were studied by PCR. The concentrations of bone tissue metabolism markers in the blood serum of 80 women were studied.Results. Homozygous TT of LCT 13910 C>T and recessive allele A VDR - Bsm1 c.IVS7 G>A were associated with increased risk of osteoporosis in women over 50 years of age living in the Trans-Baikal Territory. Heterozygous GА of VDR Bsm1 c.IVS7G>A, homozygous TT of LCT 13910 C>T were associated with increased risk of osteoporosis in Russian women. Homozygous АА of VDR Bsm1 c.IVS7G>A were associated with osteoporosis risk in Buryat women. The content of pyridinoline is increased in the blood serum of Russian women compared to Buryats. Independent predictors of the development of fractures were established: the TT genotype of the LCT and a high concentration of the ß-CrossLaps in Russian women, an increase in the level of pyridinoline and ß-CrossLaps in the blood serum of Buryats.Conclusion. The study of genetic polymorphism of bone tissue metabolite genes and markers of bone resorption in blood serum can be used as an early preclinical diagnosis of low-energy fractures in women over 50 years old living in the Trans-Baikal region.
STRESS RESISTANCE IN THE PROFESSIONAL ACTIVITY OF ANAESTHESIOLOGIST AND INTENSIVE CARE PHYSICHIAN
Authors: Ironosov V. Е. , Pshenisnov К. V. , Aleksandrovich Yu. S. 
Published: May 2024

The aim of the research is to assess stress levels and stress resistance in anesthesiologists and intensive care physicians.Materials and methods. The study includes 149 anesthesiologists and intensive care physicians working in the Russian Federation. The average age of respondents was 37,2 ± 12,1 years. Depending on age, all participants were divided into groups III: group I (under 29 years old) – 45 (30,2%) people, group II (30- 49 years old) – 77 (51,7%) and group III (over 50 years old) – 27 (18,1%) people, the sex distribution was approximately the same: 77 women and 72 men, among them 82 doctors had a family and 67 people were single. The average work experience in the specialty was 11,2 ± 11,0 years. The average diploma score of the university was 4,21 ± 0,39.Study results. It was revealed that 35% of respondents are introverts and 58% showed themselves as emotionally stable extroverts. When analyzing the results of testing according to Lusher, it was found that the majority of respondents at the first presentation of eight cards chose blue as the main color, which indicates the need for calm and peace. The maximum level of neuropsychiatric tension was characteristic of doctors working for days: 42,5 ± 9,3 points, with a minimum score of 30 points and a maximum score of 71 points. Women were characterized by higher rates, but this was not statistically significant. There was a strong statistically significant negative correlation between the level of NSP and age r = - 0,80, p < 0,05) and a direct correlation with health status (r = 0,83, p < 0,05). There was also a statistically significant direct correlation between neuropsychiatric tension level and stress resistance (r = 0,36, p < 0,05).Conclusion. The majority of anesthesiologists and intensive care physicians are characterized by extraversion, a high level of internality and sensitivity, the need for calm and peace, while the main priority in the practical activities of anesthesiologists-resuscitators is situational orientation.
STUDY OF THE LEVEL OF PROSTATIC SPECIFIC ANTIGEN AS A POTENTIAL MARKER OF RETROGRADE EJACULATION
Authors: Gal'kovich К. R. , Sosnin D. Yu. 
Published: May 2024

With retrograde ejaculation, the ejaculation mechanism changes: the expulsion of the seed fluid occurs in the proximal direction into the bladder.The aim of the research. Identification of the value of determining the concentration of prostate specific antigen (PSA) in post-orgasmic urine (POM) for the diagnosis of retrograde ejaculation.Materials and methods. 59 men (age 34,1 ± 8,9 years) were examined. The main group (n=27) consisted of men suffering from retrograde ejaculation. The comparison group (n=32) included men whose ejaculation was physiologically antegrade and who had no coitus during the previous 2 days. The concentration of total PSA in blood serum and urine was determined by solid-phase enzyme immunoassay (ELISA) using the test system "total PSA-ELISA-BEST" (T-8458) (Vector–Best LLC, Russia).Results. The median concentration of total PSA in urine in the comparison group was 9,52 times higher than the same indicator in blood serum. When comparing the content of total PSA in the main group of patients in the morning urine, in the 1st (at the beginning of the act of urination) and 2nd (at the end of the act of urination) portions of POM, we found comparable indicators of the concentration of total PSA, no significant differences were found (the Kraskel–Wallis criterion H=0,4914, p=0,9208, with a pairwise comparison between all the studied groups of urine samples, p = 1,000000).Conclusion. The level of PSA in the urine of men of fertile age is almost 10 times higher than that in blood serum. The presence of PSA in high concentration in the bladder urine may indicate various ways of getting this substance into the urine: retrograde casting of sperm during ejaculation and free filtration of this protein in the glomeruli of the kidney. The PSA total urine test is not suitable for laboratory diagnosis of retrograde ejaculation.
ROLE OF METALLOPROTEINASE-12-82A>G GENE SNP IN THE PATHOGENESIS OF COMMUNITY-ACQUIRED PNEUMONIA IN CONTRACTION-AGE PATIENTS
Authors: Zagalaev В. Т. , Miromanova N. А. , Miromanov А. М. 
Published: May 2024

The purpose of the study is to establish the significance of the MMP12-82A>G gene SNP in the pathogenesis of community-acquired pneumonia in patients of military age.Materials and methods. A survey of 160 unrelated patients of military age (18-20 years) living in the TransBaikal Territory was carried out. The first group (n=80) - patients with COVID-19 infection complicated by mild pneumonia (n=40) and severe pneumonia (n=40). Group 2 – clinical comparison (n=80) – patients with acute respiratory infection (ARI) of non-influenza etiology, complicated by mild pneumonia (n=40) and severe pneumonia (n=40). The control group consisted of 86 practically healthy men of the same age. Exclusion criteria: presence of family ties; patients with acute and/or chronic concomitant pathology. Research methods: clinical; laboratory (immunological - determination of metalloproteinase-12; genetic - polymorphism of the MMP12-82A>G gene); instrumental (computed tomography). The studies were carried out upon admission to the hospital. Statistical processing of the study results was carried out using the IBM SPSS Statistics Version 25.0 software package (IBM, USA). Results. A predominance of the -82A- allele of the MMP12-82(A>G) gene was recorded in the group with ARI and -82A/G genotype in patients with community-acquired pneumonia against the background of COVID-19 infection, while in severe cases a predominance of the -82A- allele and - was noted 82A/A genotype. An increase in the concentration of MMP-12 in the main group was found to be 3.6 times compared to the same value in the control group and 1.7 times compared to the group of community-acquired pneumonia against the background of ARI. Studying the effect of SNP MMP12-82A>G on the expression of MMP-12, a tendency was noted for its content to decrease in carriers of the -82G/G genotype.Conclusion. The -82A- allele and the -82A/A genotype of the MMP12 gene are associated with a severe course of community-acquired pneumonia (COVID-19, ARI) in patients of military age, while carriage of the -82Gallele and -82G/G genotype can be considered as a protective effect of a favorable course pathological process in the lungs. In patients of military age with community-acquired pneumonia, an increase in the concentration of MMP-12 is recorded, with the highest values in the group with severe pneumonia due to COVID-19 infection. When carrying the -82G/G genotype of the MMP12 gene, a decrease in the concentration of MMP-12 in the blood serum is recorded.
BLOOD CONTENT OF MATRIX METALLOPROTEINASE 9 IN PATIENTS WITH COVID-19- ASSOCIATED LUNG DISEASE
Authors: Karachenova А. М. , Romanova Е. N. , Karachenov R. А. 
Published: May 2024

The aim of the research. To identify the relationship between the serum content of MPP-9 and the polymorphism of the MPP-9 gene (A8202G) with the severity of the course of COVID-19-associated lung damage.Materials and methods. The paper presents the results of a survey of 200 people 1 month after suffering COVID-associated lung damage in the period from June 01 to October 31, 2020. The patients were divided into groups of 50 people depending on the degree of lung damage according to the results of computed tomography: 1st group (CT-1), 2nd group (CT-2), 3rd group (CT-3), 4th group (CT-4). The following diseases were registered in the structure of background pathology: arterial hypertension (AH), coronary heart disease (CHD), obesity, type 2 diabetes mellitus (type 2 diabetes), chronic kidney disease (CKD), COPD and bronchial asthma. The control group included 56 relatively healthy individuals who did not suffer from coronavirus infection, the median age was 55.0 [51.1; 55.0]. All groups were comparable in age and gender. The content of MMP-9 in the blood serum was studied. A molecular genetic study of the MMP-9 (A8202G) gene was also conducted.Results. As a result of the work, a lower content of MPP-9 was revealed in the control group compared to the study groups. A higher level of matrix metalloproteinase 9 was also revealed in patients with more severe COVID-19-associated lung damage (CT-4), compared to less severe patients (CT-1).Conclusion. Thus, taking into account the data obtained in patients after coronavirus infection with COVID19-associated lung damage, it can be assumed that an increased concentration of MPP-9 is one of the factors contributing to both lung damage against the background of infection and a factor in the severe course of this complication.
BIRADS 3 TUMORS ON THE ULTRASOUND: ONCOLOGICAL RISKS
Authors: Kayukova Е. V. , Kayukov V. А. , Neradovskaya Е. А. 
Published: May 2024

Introduction. BIRADS 3 tumors are an area of interest for the oncologist and the gynecologist considering likelihood of cancer less than or equal to 2%.Aim. To analyze the frequency of diagnoses in BIRADS 3 of ultrasound, to determine the risk of breast cancer in women with BIRADS 3 after the first ultrasound.Materials and methods. A prospective study was carried out, the participants of were women from the TransBaikal Regional Oncology Center with BIRADS 3 after the first ultrasound.expert-class ultrasound examination of the breast was carried out for all patients using a General Electric Voluson E6 device (Austria, 2011).The fine-needle aspiration biopsy (FNA) with cytological examination, core tumor biopsy (Biopsy needle, Italy, 14 G / 2.00 mm) with histological examination were performed according to indications.Statistical analysis was carried out using the IBM SPSS Statistics Version 25.0 program"Results. Almost every third of the woman referred to an oncologist does not have a BIRADS gradation in the ultrasound report. Changing the BIRADS category was performed in 22.4% of cases after expert ultrasound Biopsy of tumors with the BIRADS 3 was performed in 31% cases, among them breast cancer was detected in 3,4% of cases, intraductal papilloma with atypia – 1,7%.Conclusion. The use of BIRADS grading is necessary for the breast ultrasound, which affects the routing and examination. The management for patients with BIRADS 3 ultrasound should be individualized, considering clinical, radiological features.
DYNAMICS OF CORONAVIRUS INFECTION COVID-19 AND SOCIAL CHARACTERISTICS OF PATIENTS WITH TUBERCULOSIS AND HIV-ASSOCIATED TUBERCULOSIS
Authors: Kukhlov V. V. , Kukhlova D. О. , Mordyk А. V. 
Published: May 2024

The aim of the research. Assessment of the influence of social factors on the course and outcome of a new coronavirus infection COVID-19 in patients with tuberculosis and HIV-associated tuberculosis.Materials and methods. A retrospective analysis of 103 case histories of patients in 2 study groups: HIVassociated TB/COVID-19 (n=45) and TB/COVID-19 (n=58) is presented.Results. The mean age of patients with a combination of HIV-associated tuberculosis and COVID-19 infection (42,8 ± 7,2 years) is significantly lower than patients with tuberculosis and COVID-19 infection (51,3 ± 13 years). Bad habits, including drug addiction (62,2% and 3,4% in the groups, respectively) and alcoholism (93,3% and 67,2% in the groups, respectively) were associated with HIV infection. Hepatitis C (77,8% and 15,5% in the groups, respectively), refusal of further inpatient treatment (84,4% and 25,9% in the groups, respectively), stay in correctional labor institutions (ITU) (53,3% and 27,6% in the groups, respectively) were significantly more common in HIV-infected patients. Such social factors as disability, lack of work, place of residence, degree of education, living with or without relatives, marital status, housing characteristics did not affect the dynamics and outcome of the disease in general. The form and phase of the course of tuberculosis were associated with HIV infection. Type 2 diabetes mellitus was associated with the absence of HIV infection (0% and 17.2% in the groups, respectively). The severity of the course of COVID-19, the outcome of the disease at the end of inpatient treatment did not depend on the presence of HIV infection.Conclusion. No direct relationship between HIV infection and social factors associated with it with the severity of tuberculosis and the new coronavirus infection COVID-19 has been established.
PLATELET AGGREGATION FUNCTION IN PATIENTS WITH TYPE 1 DIABETES MELLITUS WITH KETOACIDOSIS OF VARYING DEGREES OF SEVERITY
Authors: Mukha N. V. , Govirin A. V. , Filev А. Р. , Fetisova N. V. , Kalashnikova N. М. 
Published: May 2024

The aim of the research. To study the aggregation function of platelets in the blood of patients with type 1 diabetes mellitus complicated by ketoacidosis, depending on the severity of ketoacidosis in the dynamics of the disease.Materials and methods. 135 patients with type 1 diabetes mellitus complicated by mild and moderate ketoacidosis were examined, respectively, on the 1st, 5th and 10th days of the disease. The average age of the patients was 29,2±8,9 years. Platelet aggregation was studied using a Biola two-channel laser platelet aggregation analyzer (model LA230, Russia).Results. It was found that in patients with type 1 diabetes mellitus complicated by moderate and severe ketoacidosis, spontaneous platelet aggregation was sharply increased compared with patients with type 1 diabetes mellitus complicated by mild ketoacidosis. The most pronounced changes were registered on the 1st and 5th days of the disease in patients with type 1 diabetes mellitus complicated by moderate and severe ketoacidosis, and on the 5th day in the same cohort of patients complicated by mild ketoacidosis.Conclusion. Clinically significant laboratory parameters in patients with type 1 diabetes mellitus complicated by ketoacidosis, indirectly indicating hypercoagulation, require drug correction.
NOS3 GENE POLYMORPHISM (G894T) IN PATIENTS WITH A COMBINATION OF BRONCHIAL ASTHMA AND TYPE 2 DIABETES MELLITUS
Authors: Pashkevich А. V. , Serebryakova О. V. 
Published: May 2024

The aim of the research. We aimed to study the prevalence of genetic variants in the NOS3 gene (G894T) related to nitric oxide production in individuals with both asthma and type 2 diabetes.Materials and methods. The study was carried out among 240 patients suffering from asthma and diabetes type 2, dividing them into three groups for comparative analysis, each of which had 80 people. Clinical examination and molecular genetic analysis of the polymorphism of nitric oxide synthase NOS3 (G894T) was performed by PCR in all groups.Results. Patients suffering from type 2 diabetes and asthma have a high frequency of G-allele polymorphism NOS3 894G/T compared with those who have only type 2 diabetes or asthma. The G-allele of the NOS3 894G/T polymorphism contributes to an increased risk of developing diabetes type 2 in patients with asthma.Conclusion. The study of NOS3 polymorphism (G894T) may be useful to identify a group of patients with asthma who are at increased risk of diabetes type 2.