bluuebunny/crossref_metadata_2025_split huggingface dataset:
The expression of myogenic regulatory factors and muscle growth factors in the masticatory muscles of dystrophin-deficient (MDX) mice
Authors: Spassov Alexander , Gredes Tomasz , Gedrange Tomasz , Lucke Silke , Pavlovic Dragan , Kunert-Keil Christiane 
Published: February 2011

AbstractThe activities of myogenic regulatory factors (MRF) and muscle growth factors increase in muscle that is undergoing regeneration, and may correspond to some specific changes. Little is known about the role of MRFs in masticatory muscles in mdx mice (the model of Duchenne muscular dystrophy) and particularly about their mRNA expression during the process of muscle regeneration. Using Taqman RT-PCR, we examined the mRNA expression of the MRFs myogenin and MyoD1 (myogenic differentiation 1), and of the muscle growth factors myostatin, IGF1 (insulin-like growth factor) and MGF (mechanogrowth factor) in the masseter, temporal and tongue masticatory muscles of mdx mice (n = 6 to 10 per group). The myogenin mRNA expression in the mdx masseter and temporal muscle was found to have increased (P < 0.05), whereas the myostatin mRNA expressions in the mdx masseter (P < 0.005) and tongue (P < 0.05) were found to have diminished compared to those for the controls. The IGF and MGF mRNA amounts in the mdx mice remained unchanged. Inside the mdx animal group, gender-related differences in the mRNA expressions were also found. A higher mRNA expression of myogenin and MyoD1 in the mdx massterer and temporal muscles was found in females in comparison to males, and the level of myostatin was higher in the masseter and tongue muscle (P < 0.001 for all comparisons). Similar gender-related differences were also found within the control groups. This study reveals the intermuscular differences in the mRNA expression pattern of myogenin and myostatin in mdx mice. The existence of these differences implies that dystrophinopathy affects the skeletal muscles differentially. The finding of gender-related differences in the mRNA expression of the examined factors may indicate the importance of hormonal influences on muscle regeneration.
Incidences of Birth Abnormalities, Congenital Defects and their Association with Consanguineous Marriages in Rajshahi: A Case Study
Authors: Islam M Saiful , Ahmed Sharmin 
Published: February 2011

Context: It has long been claimed that consanguineous marriages are deleterious to human well beings, but their association with incidences of birth abnormalities and congenital defects has not been well studied in our societies. Objectives: To investigate frequencies of common birth abnormalities and congenital defects in children from congenital marriages in Rajshahi Metropolis areas. Materials and Methods: A total of 150 clinical patients were chosen at random from 10 hospitals and clinics for recording their birth related abnormalities, whereas 281 children from 100 consanguineous couples from 17 Wards were included in the study for examining their congenital defects. All the patients, children and their parents were interviewed separately for recording the case histories.Results: Frequencies of miscarriages (0.65), stillbirths (0.38), postnatal deaths (0.30), and preterm deliveries (0.50) each in consanguineous cases differed significantly from that in non-consanguineous cases (P<0.001). In addition, significantly shortened gestational ages (34.37±4.08 wks) and lower live birth weights (3.20±0.72 kg) prevailed in the children from consanguineous marriages (P<0.001). Frequencies of six congenital defects in 76 children (30 females: 46 males) viz., deaf-mutism (0.70), cerebral palsy (0.12), mental retardation (0.11), blindness (0.04), syndactyly (0.02) and deaf-mutism coupled with mental retardation (0.01), were recorded from 100 consanguineous couples who had a total of 281 children. Conclusion: Demerits of the prevailing tradition of marrying close relatives in our society are obvious from the present results. Moreover, association between consanguinity and various birth and congenital malformations was statistically significant compared to the non-consanguineous cases.Key words: Birth abnormalities; congenital defects; consanguineous marriagesDOI: 10.3329/jbs.v17i0.7115J. bio-sci. 17: 107-112, 2009
Preliminary experience of a modified Maquet technique for repair of cranial cruciate ligament rupture in dogs
Authors: Brunel L. , Bollen G. , Balligand M. , Etchepareborde S. 
Published: February 2011

SummaryThe modified Maquet technique (MMT) uses the same principle as the tibial tuberosity advancement (TTA) for stabilization of the cranial cruciate ligament-deficient stifle in the dog. In the MMT, the tibial tuberosity is advanced in a similar manner to that used in the TTA, however the means by which the tibial crest is stabilized differs. The plate and fork originally described by Montavon et al. are not used (7). The MMT was first described by Maquet for use on humans it leaves intact a distal bony attachment to the tibial shaft, and the tuberosity is either reinforced or not by a figure-of-eight wire. In this paper, we describe the MMT, and we report the results of our first 20 canine patients with cranial cruciate ligament rupture that were treated by the MMT. Mean clinical bone healing time was 6.8 weeks (range 4 to 12 weeks).The evidence provided by this Clinical Communication suggests that it is technically possible to achieve an advancement of the tibial tuberosity without the need for a plate. The MMT deserves consideration as a primary treatment option for cranial cruciate ligament rupture in dogs, and further evaluation in large clinical studies. Long-term follow-up and force plate analysis would be necessary to compare the MMT to both the TTA and the tibial plateau levelling osteotomy.
The intercondylar fossa indices of male and female dog femora
Authors: Kilimci F. Sevil , Yildirim I. G. , Onar V. , Pazvant G. , Kara M. E. 
Published: February 2011

SummaryThe intercondylar fossa (ICF) indices can be used to evaluate fossa geometry, which may in turn affect the function, pathology and intracapsular surgical repair of the cranial cruciate ligament. The measurements of digital images of the distal femur of 44 dogs were used to calculate the fossa width, shape, height and area indices. The mean values of fossa width index were found to be 0.19, 0.28 and 0.37 at the cranial, central, and caudal levels of the fossa, respectively. The mean values for fossa shape, height and area indices were found to be 0.71, 0.33, and 0.16, respectively. The differences in ICF indices between male and female dog were not significant. Therefore, it is suggested that gender differences related to ICF geometry may not have any effect on incidence of cranial cruciate ligament injury in dogs.
Carpal canal lipoma causing lameness in a dog
Authors: Ryan T. , Scott H. W. , Szabo D. 
Published: February 2011

SummaryCarpal canal syndrome, or carpal tunnel syndrome, is the most common entrapment neuropathy in humans and is caused by compression of the median nerve as it courses through the carpal canal. A similar condition has been reported in horses, however there have not been any reported cases of a dog showing lameness secondary to compression within the carpal canal. This report describes the case of a dog exhibiting lameness secondary to a lipoma within the carpal canal. Lameness improved after surgical removal of the mass. This case highlights the need to consider compression of the tendons and nerves in the carpal canal as a cause of forelimb lameness in dogs when pain is localised to the carpus.
Use of the angularis oris cutaneous flap for repair of a rostral mandibular skin defect in a cat
Authors: Bradford M. , Bhandal J. , Degner D. A. 
Published: February 2011

SummaryThe angularis oris axial pattern flap is based on the blood supply of the angularis oris artery and vein. While the use of this flap for repair of canine facial wounds is well documented, this technique has not been reported in the cat. This Case Report presents the reconstruction of a large ventral chin and rostral lip wound with the use of this flap. Complete survival of this flap was observed in this patient.
Association of Knee Osteoarthritis with the Accumulation of Metabolic Risk Factors Such as Overweight, Hypertension, Dyslipidemia, and Impaired Glucose Tolerance in Japanese Men and Women: The ROAD Study
Authors: YOSHIMURA NORIKO , MURAKI SHIGEYUKI , OKA HIROYUKI , KAWAGUCHI HIROSHI , NAKAMURA KOZO , AKUNE TORU 
Published: February 2011

Objective.To clarify the association of knee osteoarthritis (KOA) with overweight (OW), hypertension (HTN), dyslipidemia (DL), and impaired glucose tolerance (IGT), which are components of metabolic syndrome (MS), in a Japanese population.Methods.We enrolled 1690 participants (596 men, 1094 women) from the large-scale cohort study Research on Osteoarthritis Against Disability (ROAD), begun in 2005 to clarify epidemiologic features of OA in Japan. KOA was evaluated by the Kellgren-Lawrence grade, minimum joint space width (MJSW), minimum joint space area (JSA), and osteophyte area (OPA). OW, HTN, DL, and IGT were assessed using standard criteria.Results.The prevalence of KOA in the total population in the age groups ≤ 39, 40–49, 50–59, 60–69, 70–79, and ≥ 80 years was 2.2%, 10.7%, 28.2%, 50.8%, 69.0%, and 80.5%, respectively. Logistic regression analyses after adjustment for age, sex, regional difference, smoking habit, alcohol consumption, physical activities, regular exercise, and history of knee injuries revealed that the OR of KOA significantly increased according to the number of MS components present (1 component: OR 1.21, 95% CI 0.88–1.68, p = 0.237; 2 components: OR 1.89, 95% CI 1.33–2.70, p < 0.001; 3 or more components: OR 2.72, 95% CI 1.77–4.18; p < 0.001). The number of MS components was inversely related to medial MSJW (ß = −0.148, R2= 0.21, p < 0.001), medial JSA (women only; ß = −0.096, R2= 0.18, p = 0.001), and positively related to OPA (ß = 0.12, R2= 0.11, p < 0.001).Conclusion.The accumulation of MS components is significantly related to presence of KOA. MS prevention may be useful to reduce cardiovascular disease and KOA risk.
Differentiation Between Wegener’s Granulomatosis and Microscopic Polyangiitis by an Artificial Neural Network and by Traditional Methods
Authors: LINDER ROLAND , ORTH ISABELLE , HAGEN E. CHRISTIAN , van der WOUDE FOKKO J. , SCHMITT WILHELM H. 
Published: February 2011

Objective.To investigate the operating characteristics of the American College of Rheumatology (ACR) traditional format criteria for Wegener’s granulomatosis (WG), the Sørensen criteria for WG and microscopic polyangiitis (MPA), and the Chapel Hill nomenclature for WG and MPA. Further, to develop and validate improved criteria for distinguishing WG from MPA by an artificial neural network (ANN) and by traditional approaches [classification tree (CT), logistic regression (LR)].Methods.All criteria were applied to 240 patients with WG and 78 patients with MPA recruited by a multicenter study. To generate new classification criteria (ANN, CT, LR), 23 clinical measurements were assessed. Validation was performed by applying the same approaches to an independent monocenter cohort of 46 patients with WG and 21 patients with MPA.Results.A total of 70.8% of the patients with WG and 7.7% of the patients with MPA from the multicenter cohort fulfilled the ACR criteria for WG (accuracy 76.1%). The accuracy of the Chapel Hill criteria for WG and MPA was only 35.0% and 55.3% (Sørensen criteria: 67.2% and 92.4%). In contrast, the ANN and CT achieved an accuracy of 94.3%, based on 4 measurements (involvement of nose, sinus, ear, and pulmonary nodules), all associated with WG. LR led to an accuracy of 92.8%. Inclusion of antineutrophil cytoplasmic antibodies did not improve the allocation. Validation of methods resulted in accuracy of 91.0% (ANN and CT) and 88.1% (LR).Conclusion.The ACR, Sørensen, and Chapel Hill criteria did not reliably separate WG from MPA. In contrast, an appropriately trained ANN and a CT differentiated between these disorders and performed better than LR.
Le surmoi et le transgénérationnel
Authors: Eiguer Alberto 
Published: February 2011

Résumé Le surmoi individuel et familial est le produit de multiples facteurs. L’auteur traite des origines transgénérationnelles du surmoi. Cette idée s’inscrit dans la ligne de nombreuses découvertes freudiennes, notamment celles de surmoi culturel, d’intersubjectivité, de fantasme originaire, d’imago. Elle a peut-être influencé Freud lorsqu’il a souhaité redéfinir le surmoi comme une instance, en 1923. Toutefois, l’apport de la TFP se particularise par la mise en lumière de la part active et permanente de la groupalité familiale ; le surmoi s’active et se mobilise en se recréant constamment. Cela implique des perspectives thérapeutiques encourageantes, à condition toutefois que les thérapeutes soient sensibles à cette idée en adaptant leurs outils interprétatifs (pas uniquement le contenu de leurs interprétations). Dans la partie clinique, l’auteur parle de ces familles où la transgression de la loi se fait sentir (maltraitance, violence, inceste, délinquance) ; on peut lier ces manifestations avec les défaillances dans le processus de transmission générationnelle. Les questions du secret et du mythe s’avèrent aussi importantes que celle du don et de la dette impayée. Pendant la thérapie des familles « transgressives », le contre-transfert est sollicité de manière particulière au point de produire malaise, dégoût, rejet. Or si le contre-transfert se montre si « récalcitrant », comment construire une relation thérapeutique ? Le transgénérationnel dans le vécu des thérapeutes ne peut-il y jouer un rôle de dégagement et permettre à ces derniers de trouver une « empathie concevable » ? Et lequel ? L’auteur illustre ces idées par une TFP d’inceste.
Le rôle du transgénérationnel dans le lien de couple
Authors: Joubert Christiane 
Published: February 2011

Résumé En référence à S. Freud (1914) et à ses deux modèles de choix d’objet, et à d’autres psychanalystes contemporains, l’auteur montre, à travers quelques séquences de psychanalyse de couple et de famille, un mode de choix d’objet transgénérationnel, sans doute le plus inconscient, à l’œuvre dans le lien conjugal, en toile de fond. Les « pactes dénégatifs », à la base de tout lien, selon R. Kaës (1987), représentations inconscientes, refoulées, déniées, infiltrées de traces transgénérationnelles, telles que les cryptes, fantômes, secrets, traces sans mémoire, comme le dit E. Granjon (2005), participent à la constitution du lien d’alliance et sont à l’œuvre en son sein. Les aspects transgénérationnels au sein des lignées de chaque partenaire entrent en résonance dans la rencontre, sur un mode inconscient. Le lien conjugal se construit et repose sur les failles de la filiation de chacun des partenaires. Le transgénérationnel est donc à l’œuvre dans la crise du couple qui se « déstructure » ce sur quoi il s’était fondé inconsciemment.
Se reconnaître dans la filiation
Authors: Eiguer Alberto 
Published: February 2011

Résumé L’auteur aborde le thème de la reconnaissance en rappelant les analystes et les philosophes qui ont souligné son intérêt novateur. Pour incontestable que soit son rôle en famille, elle présente quelques particularités inhérentes à la question du lien de filiation. L’auteur examine alors la reconnaissance mutuelle des fonctions du parent et de l’enfant comme fondatrice de leur lien. Il considère ainsi la nomination de l’enfant, forme majeure de « l’être reconnu », et son emplacement sur l’échiquier familial et dans les lignées, sa découverte et son intégration nécessitant un travail conséquent. Il étudie les conséquences cliniques du défaut de reconnaissance, repéré notamment dans les pathologies du lien agissantes et perverses.
Du mépris à la reconnaissance. Réflexions sur la psychothérapie des familles migrantes
Authors: Métraux Jean-Claude 
Published: February 2011

Résumé Dans sa pratique de psychothérapeute de famille, l’auteur rencontre de nombreuses familles migrantes ayant derrière elles une longue histoire de souffrance sociale, de jugements et mépris endurés. Il a réalisé la nécessité, face à elles, de réformer certains des principes thérapeutiques. Les changements proposés s’appuient sur une réflexion autour du concept de reconnaissance. Trois formes majeures de reconnaissance, elles-mêmes subdivisées, peuvent être identifiées : la reconnaissance mutuelle (approbation, gratitude, reconnaissance des droits d’autrui, estime sociale), la reconnaissance de soi-même (pouvoir se raconter, pouvoir dire et agir, reconnaissance de ses compétences, reconnaissance de sa responsabilité, reconnaissance de la promesse du lien) et la reconnaissance par identification (reconnaissance de son ignorance, similitudes fondamentales, reconnaissance de la souffrance). Les propositions concrètes faites aux thérapeutes familiaux pour assurer ces multiples formes de reconnaissance constituent les bases d’une véritable thérapeutique de la reconnaissance.
La violence n'a pas de sexe
Authors: Bouchat-Trezzini Adriana 
Published: February 2011

Résumé L’auteur propose une réflexion sur la violence conjugale qui tient compte des enjeux inconscients entre les deux partenaires. La violence conjugale n’est pas l’apanage de l’un ou de l’autre sexe. Elle est souvent le résultat d’une construction à deux, dans le contexte d’une organisation relationnelle marquée par la perversion narcissique. L’analyse de la pièce Qui a peur de Virginia Woolf ? d’Edward Albee sert ici de vignette clinique.
Destructivité et mort dans une thérapie familiale psychanalytique
Authors: Sommantico Massimiliano , Trapanese Gemma 
Published: February 2011

Résumé Les auteurs discutent un cas de thérapie psychanalytique d’une famille monoparentale où semble régner la pulsion de mort. Divers éléments sont à souligner : le couple parental, caractérisé par une dynamique violente durant plusieurs années, a divorcé à la demande de la mère ; la fille aînée, qui a suivi plusieurs psychothérapies depuis son enfance, a fait une tentative de suicide après le décès des grands-parents maternels avec lesquels elle avait un lien très fort ; la fille cadette présente des conduites auto-agressives. À la lumière de ces données les auteurs s’interrogent particulièrement sur la transmission, dans cette famille-là, d’un masochisme très massif, aussi bien que d’un sentiment très intense de culpabilité. Une attention particulière est portée à la destructivité présente dans cette famille, notamment au geste suicidaire, entendu comme révélateur d’une souffrance familiale très grave.
La transmission : une violence nécessaire dans les liens
Authors: Joubert Christiane 
Published: February 2011

Résumé L’auteur considère la transmission entre générations comme une violence faite à l’ infans , ceci à double titre : 1) par ses modalités, car elle se fait à son insu, sous forme de traces, de « pictogrammes » ; 2) par ses contenus qui portent souvent sur un passé familial refoulé, non dit car traumatique ou honteux, et présent sous la forme des « fantômes » ou « cryptes ». Ces contenus violents, lorsqu’ils prédominent, sont à l’origine de dysfonctionnements familiaux et de troubles psychiques individuels. La thérapie familiale psychanalytique est proposée comme moyen de réélaboration groupale de ces contenus en vue de leur appropriation consciente par la famille et par l’individu.
Monotonically Controlled Mappings
Authors: Pavlíček Libor 
Published: February 2011

AbstractWe study classes of mappings between finite and infinite dimensional Banach spaces that are monotone and mappings which are differences of monotone mappings (DM). We prove a Radó–Reichelderfer estimate for monotone mappings in finite dimensional spaces that remains valid for DM mappings. This provides an alternative proof of the Fréchet differentiability a.e. of DM mappings. We establish a Morrey-type estimate for the distributional derivative of monotone mappings. We prove that a locally DM mapping between finite dimensional spaces is also globally DM. We introduce and study a new class of the so-called UDM mappings between Banach spaces, which generalizes the concept of curves of finite variation.
Some Properties Associated with Adequate Transversals
Authors: Kong Xiangjun 
Published: February 2011

AbstractIn this paper, another relationship between the quasi-ideal adequate transversals of an abundant semigroup is given. We introduce the concept of a weakly multiplicative adequate transversal and the classic result that an adequate transversal is multiplicative if and only if it is weakly multiplicative and a quasi-ideal is obtained. Also, we give two equivalent conditions for an adequate transversal to be weakly multiplicative. We then consider the case when I and Λ (defined below) are bands. This is analogous to the inverse transversal if the regularity condition is adjoined.
Review of Reported Clinical Information System Adverse Events in US Food and Drug Administration Databases
Authors: Myers R.B. , Jones S.L. , Sittig D.F. 
Published: February 2011

Summary
Background: The US FDA has been collecting information on medical devices involved in significant adverse advents since 1984. These reports have been used by researchers to advise clinicians on potential risks and complications of using these devices.
Objective: Research adverse events related to the use of Clinical Information Systems (CIS) as reported in FDA databases.
Methods: Three large, national, adverse event medical device databases were examined for reports pertaining to CIS.
Results: One hundred and twenty unique reports (from over 1.4 million reports) were found, representing 32 manufacturers. The manifestations of these adverse events included: missing or incorrect data, data displayed for the wrong patient, chaos during system downtime and system unavailable for use. Analysis of these reports illustrated events associated with system design, implementation, use, and support.
Conclusion: The identified causes can be used by manufacturers to improve their products and by clinical facilities and providers to adjust their workflow and implementation processes appropriately. The small number of reports found indicates a need to raise awareness regarding publicly available tools for documenting problems with CIS and for additional reporting and dialog between manufacturers, organizations, and users.
The Influence of the Solubility of Accelerators on the Vulcanization of Elastomer Blends
Authors: Guillaumond F-X. 
Published: February 2011

Abstract
The various results obtained in the course of this study show that the solubility of the curing ingredients exercises an influence on the properties of the vulcanizate of a blend of elastomers when the latter are incompatible. If, in the preparation of the blend, the two elastomers contain the same levels of the curing ingredients, the latter undergo rapid migration at the temperature of vulcanization from the phase in which they are less soluble toward the phase in which they are more soluble. This unbalances their distribution, and the impoverished phase vulcanizes more slowly and less completely. In the limiting case, it cannot vulcanize at all and, hence, plays the role of diluent filler. if, on the contrary, the phase with the higher solubility of the curing ingredients at the vulcanization temperature is saturated initially, migration does not occur, and the two phases can covulcanize. However, for obvious reasons, such a procedure is not technically feasible and is useful only in demonstrating the principle. The solution lies rather in use of accelerators which have the same solubility in each of the elastomers of the blend. This is the way which has been followed by certain investigators, but the products have not yet been commercialized. One might equally envision an investigation of combinations of accelerators which will form eutectic mixtures having identical solubility in the two different elastomers.