bluuebunny/crossref_metadata_2025_split huggingface dataset:
Capacity assessment for EHR-based medical device post-market surveillance for synthetic mid-urethral slings among women with stress urinary incontinence: a NEST consortium study
Authors: Matheny Michael E , Perkins Amy M , Rieger-Christ Kimberly , Ross Joseph S , Mao Jialin , Sedrakyan Art , Shah Nilay D , Winter Robert , Reynolds W Stuart , Mourtzinos Arthur , Schulz Wade L , Bartlett Victoria , Solotke Michael , Pandya Sameer , Aryal Suvekshya , Cho Ahra , Frankenberger Edward A , Park Daniel , Bostrom Danielle , Robbins Susan , Yustein Aron , Chughtai Bilal , Trabuco Emanuel C 
Published: February 2025

ObjectivesTo evaluate the feasibility for use of electronic health record (EHR) data in conducting adverse event surveillance among women who received mid-urethral slings (MUS) to treat stress urinary incontinence (SUI) in five health systems.DesignRetrospective observational study using EHR data from 2010 through 2021. Women with a history of MUS were identified using common data models; a common analytic code was executed at each site. A manual chart review was conducted in a per-site random patient subset to establish a reference standard. Automated text processing (Text Processed Integrated (TPI)) was developed and evaluated at each site to determine the surgical approach and synthetic mesh implantation. Patients were characterized and surgical outcomes were ascertained over 730 subsequent days.SettingFive large tertiary care academic medical centers.ParticipantsAcross five health systems, 9,906 eligible patients (mean age 57–60 per site) were identified.Main outcome measuresDetermination of surgical approach, synthetic mesh implantation, and assessment of the duration of surveillance for mortality and reoperation rates following MUS implantation.ResultsIn the TPI cohort analysis, 3,331 patients were identified. Surgical approach per site was retropubic (42% to 77%), transobturator (6% to 44%), single incision (0% to 24%), and adjustable sling (0% to <4%). Concordance rates for TPI using chart review were 71%–90% at each site for the surgical approach and 28%–85% for synthetic mesh implantation. Patient follow-up observation rates for mortality and reoperation ranged from 22% to 36% at 90 days, 15% to 30% at 365 days, and 8% to 19% at 730 days.ConclusionUsing EHR data alone, identification of medical devices and surgical approaches was feasible among women with MUS surgery for SUI, but long-term follow-up ascertainment rates were low. Medical device surveillance using EHR data should be evaluated in the context of the clinical use case, as applicability may vary.
Long-term safety and efficacy of the combination of belimumab and rituximab in the treatment of severe and refractory SLE: a preliminary report
Authors: van Schaik Mieke , Arends Eline J , Wetzels Marjolein J A L , Kraaij Tineke , Verbruggen Stéphanie H , van der Kooij Sandra W , Kamerling Sylvia W A , Huizinga Tom , Goekoop Robbert J , van Kooten Cees , Rabelink Ton , Teng Y K Onno 
Published: February 2025

ObjectiveCombination therapy with rituximab and belimumab is a novel treatment strategy for severe SLE and lupus nephritis. Phase II studies have shown promising results, although long-term data are currently lacking. To address this, we analysed outcomes of patients with severe treatment-refractory SLE who previously participated in the phase II Synbiose Study, with a particular focus on immunological parameters.MethodsEight patients continued belimumab treatment beyond the 2-year duration of the original trial. We conducted a descriptive study to evaluate the course of treatment and immunological parameters over an extended follow-up. Our analyses include blood cell counts, immunoglobulins, autoantibodies, complement markers and clinical disease activity parameters. Additionally, we examined long-term effects on the B cell compartment employing high-sensitivity flow cytometry.ResultsOver a median follow-up period of 6.8 years, six out of eight previously treatment-refractory patients maintained long-term clinical remission, while two experienced a major flare. Among those in remission, two patients achieved immunosuppression-free remission, and four continued belimumab. Long-term effects on humoral (auto-)immunity were a persistent decrease in IgM levels, while IgG normalised. Most patients maintained low autoantibody titres, and complement markers remained normal. On the cellular level, belimumab treatment after rituximab prevented B cell repopulation. Notably, patients exhibited a stable reduction of double-negative (DN) B cells, irrespective of continuing or stopping belimumab.ConclusionsLong-lasting remission was observed in patients with SLE following combination treatment with rituximab and belimumab. We observed no significant hypogammaglobulinaemia and, notably, persistent reduction of DN B cells.
Investigating the Link Between Biofilm Formation and Antibiotic Resistance in Clinical Isolates of Acinetobacter baumannii
Authors: Javadi Kasra , Ghaemian Poorya , Baziboron Mana , Pournajaf Abazar 
Published: February 2025

Background: Acinetobacter baumannii has become a significant problem in hospitals worldwide during the last decades. Biofilm formation is a virulence factor that may affect antibiotic resistance. This study aimed to elucidate the correlation between biofilm formation and biofilm‐related and oxacillinase genes in A. baumannii clinical isolates.Methods: This study was conducted on 53 A. baumannii isolates collected from hospitals affiliated with Babol University of Medical Sciences (Babol, Iran) from April to October 2023. Kirby–Bauer disc diffusion was used to determine antibacterial resistance. Biofilm formation was examined using crystal violet staining. Polymerase chain reaction was used to detect oxacillinase (blaOXA−23, blaOXA−24, blaOXA−51, and blaOXA−58) and biofilm‐encoding (bap and blaPER−1) genes using specific primers.Results: The strains showed the highest resistance to trimethoprim/sulfamethoxazole and ciprofloxacin (98.11%) and the lowest resistance to ampicillin/sulbactam (66.03%). All isolates formed biofilms. Also, 67.92%, 18.86%, and 11.32% were strong, moderate, and weak biofilm producers, respectively. The frequencies of blaOXA−23, blaOXA−24, blaOXA−51, bap, and blaPER−1 genes were 92.45%, 71.69%, 100%, 73.58%, and 58.49%, respectively. None of the isolates harbored blaOXA−58.Conclusions: A high prevalence of antibiotic‐resistant strains was found among A. baumannii clinical isolates. There was no significant correlation between the clinical sample type and biofilm formation, but a notable link was found between antimicrobial resistance and biofilm formation, except for ciprofloxacin. Oxacillinase genes were not significantly correlated with biofilm formation, but biofilm production was associated with bap rather than blaPER−1. Understanding the A. baumannii biofilm formation process is crucial for effective control of associated infections by targeting this mechanism.
Bridging Gaps in Pain Management: The Effectiveness of Educational Intervention for Nurses in a Teaching Hospital of Low‐ and Middle‐Income Countries
Authors: Siddiqui Ali Sarfraz , Zehra Tabassum , Afshan Gauhar , Shakil Sara , Ahmed Aliya 
Published: February 2025

Background: Regular on‐the‐job training and educational courses may improve nurses’ knowledge and practice regarding pain assessment and initial treatment.Objectives: To assess the impact of a newly developed educational course in terms of improvement in knowledge regarding pain assessment and initial treatment by using pretest and posttest multiple‐choice question scores and to determine the retention of knowledge 3 months after the educational course and perceived change in clinical practices among nurses working in adult surgical and medical wards at the Aga Khan University Hospital.Methods: After getting approval from the institutional review committee, an education course was developed and conducted. A total of 86 participants attended both online and physical components. Teaching methodologies included online lectures, small group tutorials and hands‐on workshops using demonstrations of locally developed videos. Pretests and posttests were conducted to assess the knowledge. All participants were requested to complete an online questionnaire to know the impact of the course on their clinical practice.Results: Eighty‐six participants completed the course, of which 52 (60.5%) were female and 34 (39.5%) were male. The mean difference between the pretest and posttest scores of participants was 4.72 (39.66%), which was statistically significant (p ≤ 0.001). The mean posttest multiple‐choice question score of participants was 16.70 ± 3.56, and the mean posttest multiple‐choice question score of participants after 3 months was 15.60 ± 4.09 with a mean difference of 1.10 (6.59%), which was not statistically significant (p = 0.121).Conclusion: The hybrid educational course had a significant learning impact on the knowledge of participants and their clinical practice.
Escrita Epífita: Tradução do El Licenciado Torralba de Ramón de Campoamor por D. Pedro II
Authors: Sackl Ana Maria B. Conrad 
Published: February 2025

The aim of this study is to analyze the translation manuscript made by Pedro II (Brazilian Emperor), of the work entitled El Licenciado Torralba by Ramón de Campoamor from Spanish into Portuguese. The manuscript dates from 1889 and was made during the deposed Emperor's exile trip. It is contained in a small book, the initial pages of which have been lost. The translation, written in pencil, is superimposed on the Spanish work, which I call Epiphyte. It is a poem in eight chapters, of which 174 pages have been translated. Today it belongs to the library of the Mariano Procópio Museum in Juiz de Fora, Minas Gerais, Brazil, and was discovered in April 2024. In this text I present a brief genetic dossier, which elucidates the translator's Hispanic interest and engagement in the literary and cultural conjuncture of the 19th century, and a summary that brushes over the lost initial pages of the work and brings context to the leitmotif of the work. Finally, I present an analysis of two translated pages in the light of genetic criticism.
Use of Advanced Echocardiographic Modalities to Discriminate Preclinical Hypertrophic Cardiomyopathy Mutation Carriers From Non-Carriers
Authors: Lo Ada K.C. , Mew Thomas , Mew Christina , Guppy-Coles Kristyan , Dahiya Arun , Ng Arnold , McGaughran Julie , McCormack Louise , Prasad Sandhir , Atherton John J. 
Published: February 2025

BACKGROUND:
It remains challenging to determine which hypertrophic cardiomyopathy (HCM) family members will subsequently develop HCM. Standard 2-dimensional and conventional Doppler echocardiography have been unable to reliably distinguish HCM genotype-positive and phenotype-negative (G+P−) from genotype-negative and phenotype-negative (G−P−) family members. We aimed to determine if advanced echocardiographic modalities can discriminate HCM G+P− from G−P− individuals.

METHODS:
Comprehensive echocardiography including speckle tracking evaluation of myocardial deformation and color M-mode were performed in 199 participants aged ≥16 years who had undergone genetic testing from families with a known HCM pathogenic variant: 58 G+P−, 39 G−P−, and 102 overt patients with HCM (genotype-positive and phenotype-positive). The primary analysis compared these measures in all G+P− and G−P− individuals. A secondary analysis was undertaken in younger subjects (age ≤40 years).

RESULTS:

Comparing G+P− and G−P− individuals, there were no significant differences in left ventricular ejection fraction, cavity size, wall thickness and outflow tract gradient, and tissue Doppler-derived myocardial velocities; however, septal/posterior wall thickness ratio was higher (1.06±0.09 versus 1.02±0.04,
P
=0.007). G+P− individuals had significantly lower color M-mode flow propagation velocity (color M-mode velocity propagation, 42.6 cm/s [interquartile range, 34.5–48.5 cm/s] versus 51.0 cm/s [interquartile range, 45.2–61.0 cm/s];
P
<0.001) and higher global longitudinal strain (
P
=0.021), circumferential strain (
P
=0.003), and peak apical rotation (
P
=0.005). Multivariable logistic regression identified 2 independent predictors (color M-mode velocity propagation and peak apical rotation). A derived regression equation allowed reasonable discrimination of G+P− individuals with a sensitivity of 82.6% and specificity of 72.2% (
P
<0.0001) at the optimal cutoff. Similar findings were demonstrated when the analysis was restricted to younger subjects, although in addition to color M-mode velocity propagation and apical rotation, left ventricular ejection fraction was also independently predictive.

CONCLUSIONS:
In HCM family members, color M-mode velocity propagation and apical rotation provide good sensitivity and specificity for identifying mutation carriers and may represent early disease markers before the onset of hypertrophy. Longitudinal studies involving larger cohorts are required to validate these findings.
A Woman, a Snake, and a Bear-Woman: An Intertextual Reading of the Garden of Eden Story (gen 2:4b–3:24) In Relation to a Korean Origin Myth
Authors: Choi Park Caroline 
Published: February 2025

Abstract
This article seeks an alternative interpretation of the Garden of Eden story by reading it intertextually with a Korean origin myth, Dangun Shinhwa. Reflecting the animistic Korean indigenous culture, the myth portrays fluid boundaries between humans, animals, and gods, serving to undermine commonly anthropocentric and androcentric interpretations of the biblical story. Cued by animistic aspects of Dangun Shinhwa, the first part of the article rereads Genesis 2 through animism, leading to different interpretations of the characters—human and nonhuman beings and God—and the ontology of their world. Thus informed, the second part reads Gen 3 alongside Dangun Shinhwa, which features a bear who becomes a woman and later the mother of Korean people. The reading yields an alternative meaning to the familiar story about the human loss of connections and soul unawareness, foretelling the tragedy of today’s carno-phallogocentric world.
The ethological shortfall: case study of an endangered shorebird
Authors: Miller Edward H. , Tomkovich Pavel S. , Arkhipov Vladimir Yu. , Vyn Gerrit 
Published: February 2025

Abstract
Poor knowledge of animal behaviour impedes understanding of ecology and evolution and reduces human appreciation of the natural world. We call this the ‘ethological shortfall’, parallel to Linnean and other knowledge shortfalls in conservation biology and systematics. We analysed sound recordings of breeding spoon-billed sandpipers (Scolopacidae: Calidris pygmaea), a critically endangered species. Sixteen years of field research, and a focused short-term study, provided material for our study. All the species’ calls are unique within its clade; hence our findings have immediate practical use for detecting individuals within the breeding period. No sound recordings exist for the lengthy non-breeding period, when most anthropogenic impacts occur. This gap needs to be filled, so that inventories and automated detection can be conducted in that period. We discovered information that is new and has scientific and practical applications at both the species and higher taxonomic levels (e.g., species-specificity of brief ‘alarm’ notes). We conclude that a useful account of endangered species’ behaviour can be obtained through first-hand knowledge of natural history, a research plan based on knowledge of related species, and targeted sampling.
Flow state, resilience, and performance strategies in elite three-day eventing equestrian athletes
Authors: Johnson A.E. , Carson S. 
Published: February 2025

Abstract
This study investigated the roles of psychological resilience, performance strategies, and flow state in elite equestrian three-day event riders, building on previous equestrian sport literature and bridging the gap in research about three-day eventing athletes relative to athletes in other equestrian disciplines. In order to better understand personal traits and states in athletes and individuals in high-physical-risk and sustained focus performance domains, this study examined baseline resilience levels, performance strategies used in specific competitions, and the flow state of event riders in those same competitions. The objective was to determine if performance strategies employed by elite three-day eventing athletes were related to baseline resilience and flow state characteristics, and if baseline resilience levels were related to levels of flow state within the group. Participants included 94 international level three-day eventing athletes (15 males, 78 females, 1 undisclosed; age 31.5 ± 8.85) competing in the United States in the Spring 2021 Fédération Equestre International eventing season. Results demonstrated a modest but significant correlation (, ) between baseline resilience levels (measured by the CD-RISC-10) and flow state (measured by the Flow Short Scale) for all athletes. Performance strategies were measured by the Test of Performance Strategies (TOPS). Regression analyses indicated that the performance strategies subscales of emotional control and negative thinking were found to predict flow state (, , ). The sub-scales of goal setting, automaticity, emotional control, and self-talk predicted resilience (, , ). No significant findings emerged between an athlete’s highest level of experience and their resilience scores (, ) or flow scores (, ). This study indicates a self-selection of riders in the elite levels of three-day eventing based on those who already demonstrate high levels of resilience as well as high propensity for experiencing flow state in competition.
The Development of Ci Poetry Criticism in Song Literary Miscellanies: an Evaluation of Li Yu, Liu Yong, and Su Shi
Authors: Ding Fang 
Published: February 2025

Abstract
The literary miscellanies of the Song dynasty offer a rich corpus of material on ci poetry, including comprehensive analyses of three seminal ci poets from the Five Dynasties period and the Song dynasty: Li Yu, Liu Yong, and Su Shi. Li Yu holds the distinction of being the first literati ci poet in Chinese literary history. Liu Yong made significant contributions to the evolution of ci forms and techniques, while Su Shi revolutionized the style of ci and elevated its artistic realm. The literary miscellanies of the Song dynasty offer extensive commentary on these three poets, providing valuable insights into the evolution of ci poetry. In their analyses, the Song literati bifurcated Li Yu’s ci oeuvre into pre- and post-dynastic fall. They expressed sympathy for his ill-fated life, acknowledging his superior literary talents in contrast to his political abilities, and lauded his ci works that articulated “the sorrowful and contemplative tones of a fallen dynasty.” These scholars recognized Li Yu’s contribution in giving voice to the literati through the medium of ci. Liu Yong’s ci received mixed evaluations; while his vulgar style was both criticized and affirmed, his prolific creation of manci and narrative techniques garnered general approval. Regarding Su Shi, the literati commended his elevation of ci’s literary quality and his pioneering of the bold and unconstrained style. They offered nuanced critiques of his musical deficiencies in ci composition and his approach of composing ci as a secondary pursuit. The literary miscellanies also present balanced assessments of the debate between Liu and Su’s respective styles. These discussions are instrumental in laying the foundation for a systematic criticism of Chinese ci poetry.
Gryllus locorojo or Gryllus assimilis? – PCR-based differentiation of two commonly confused crickets for pet and livestock feeding
Authors: König F. , Zagon J. , Garino C. , Winkel M. 
Published: February 2025

Abstract
A real-time polymerase chain reaction (PCR)-based protocol (Gloco-PCR) was validated to specifically detect Gryllus locorojo, a Gryllus species on the European market often mistaken for Gryllus assimilis. Whereas the latter species is allowed in the EU for feeding farmed animals, G. locorojo is only permitted for pets according to the current legislation. The method was developed on the basis of the cytochrome oxidase I gene, (COI), which was sequenced with thoroughly characterised G. locorojo and G. assimilis samples. The method is highly sensitive, detecting 0.8 pg G. locorojo-DNA or 0.1% G. locorojo incurred in feed, respectively. Authentic G. assimilis specimens were used to ensure that the G. locorojo method (Gloco-PCR) discriminates this closely related sister taxon, with a comfortable Ct-difference of 10-15. For cross analysis of true G. assimilis, similar primers with another probe were employed (Gassim-PCR) and the annealing temperature was increased from 60 °C to 62 °C. Under these conditions, authentic G. assimilis crickets were detectable with Ct-values around 20, while G. locorojo samples showed a low detection at cycles around Ct 35. An investigation of ten ‘G. assimilis’ samples collected from Germany and four other European countries revealed that all of them were of the G. locorojo type. This proves the usefulness of our approach and supports the assumption that many G. assimilis crickets marketed in the EU indeed belong to the species G. locorojo. Consequently, European legislation, currently based on a white list of allowed insect species, is critically questioned.
Informed consent in neurosurgery with particular reference to alternatives to proposed surgery. Updated case law including McCulloch.
Authors: Todd Nicholas , Wright-Todd James 
Published: February 2025

Introduction Informed consent is a crucial element in neurosurgical practice; failures of the consenting process are a common cause of litigation in neurosurgery and judgments that have particular relevance to neurosurgical practice will be reviewed here. Guidance for consent based upon current case law is discussed. Methods The legal databases BAILII and WestLaw were searched using the search term “informed consent”. The BAILII search yielded 86 abstracts, WestLaw yielded 33. There were 15 duplicates. Ten of the remaining 104 abstracts were commentaries, leaving 94 judgments. From those judgments a further 21 cases were added. A total of 115 judgments were reviewed by both authors. Results A total of 23 judgments dealing with issues of informed consent in neurosurgical and other surgical practice were selected. The cases and their implications for neurosurgical consent are discussed below. Discussion When proposing a surgical procedure to a competent adult, the treating surgeon must discuss the benefits, risks and alternatives to treatment with the patient. The surgeon can be guided by professional guidance from the GMC, or another professional body, and/or case law. Relevant issues include: (i) the risks and benefits of surgery; (ii) information that is accurate (or inaccurate, incorrect, missing or late information); (iii) established practice; (iv) the current state of knowledge; (v) reasonable alternative treatments; and (vi) surgery performed on a different day or by a different surgeon.