bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effectiveness of personal development planning
Authors: Bullock Kate , Jamieson Ian 
Published: December 2010

ABSTRACTOver recent years, the development of strategies in schools and colleges to support individual student needs and encourage autonomous learning has influenced the work of most teachers and tutors. Personal Development Plans (PDPs) draw on good practice in careers guidance and on many of the educational initiatives introduced over the past decade, particularly, Records of Achievement (RoAs) and the Technical and Vocational Education Initiative (TVEI). The focus of PDPs is a dialogue between student and tutor which clarifies choices, identifies goals and plans appropriate actions. This process aims to raise personal understanding and motivation and, ultimately, school effectiveness. This article arises from an evaluation of the Personal Development Plans (PDP) project in Wiltshire.The Wiltshire project was initiated in January 1992, and was a joint venture by the Careers Guidance Service, the local authority advisory service, TVEI and Wiltshire Training and Enterprise Council (TEC). These agencies perceived PDPs as a co‐operative project which, first, could make a highly positive contribution to the TEC's aim of promoting and sustaining a lifelong learning culture in the county; second, could provide the impetus to attain the National Targets for Education and Training (NTETs) which have been articulated for the year 2000 (DES, 1991) and hence, increase school effectiveness; and third, would ease the introduction of youth credits in the county by enabling 16‐year‐olds to make well‐informed decisions (Ruthven and Pike, 1993). Findings from the evaluation of Wiltshire PDPs are discussed. Positive strategies for supporting PDPs are suggested, the nature of the one‐to‐one dialogue is probed, and a hierarchy of concerns for practitioners is suggested.
Using non-uniform read distribution models to improve isoform expression inference in RNA-Seq
Authors: Wu Zhengpeng , Wang Xi , Zhang Xuegong 
Published: December 2010

Abstract
Motivation: RNA-Seq technology based on next-generation sequencing provides the unprecedented ability of studying transcriptomes at high resolution and accuracy, and the potential of measuring expression of multiple isoforms from the same gene at high precision. Solved by maximum likelihood estimation, isoform expression can be inferred in RNA-Seq using statistical models based on the assumption that sequenced reads are distributed uniformly along transcripts. Modification of the model is needed when considering situations where RNA-Seq data do not follow uniform distribution.
Results: We proposed two curves, the global bias curve (GBC) and the local bias curves (LBCs), to describe the non-uniformity of read distributions for all genes in a transcriptome and for each gene, respectively. Incorporating the bias curves into the uniform read distribution (URD) model, we introduced non-URD (N-URD) models to infer isoform expression levels. On a series of systematic simulation studies, the proposed models outperform the original model in recovering major isoforms and the expression ratio of alternative isoforms. We also applied the new model to real RNA-Seq datasets and found that its inferences on expression ratios of alternative isoforms are more reasonable. The experiments indicate that incorporating N-URD information can improve the accuracy in modeling and inferring isoform expression in RNA-Seq.
Contact: zhangxg@tsinghua.edu.cn
Supplementary information: Supplementary data are available at Bioinformatics online.
Lipid Data Analyzer: unattended identification and quantitation of lipids in LC-MS data
Authors: Hartler Jürgen , Trötzmüller Martin , Chitraju Chandramohan , Spener Friedrich , Köfeler Harald C. , Thallinger Gerhard G. 
Published: December 2010

Abstract
Motivation: The accurate measurement of the lipidome permits insights into physiological and pathological processes. Of the present high-throughput technologies, LC-MS especially bears potential of monitoring quantitative changes in hundreds of lipids simultaneously. In order to extract valuable information from huge amount of mass spectrometry data, the aid of automated, reliable, highly sensitive and specific analysis algorithms is indispensable.
Results: We present here a novel approach for the quantitation of lipids in LC-MS data. The new algorithm obtains its analytical power by two major innovations: (i) a 3D algorithm that confines the peak borders in m/z and time direction and (ii) the use of the theoretical isotopic distribution of an analyte as selection/exclusion criterion. The algorithm is integrated in the Lipid Data Analyzer (LDA) application which additionally provides standardization, a statistics module for results analysis, a batch mode for unattended analysis of several runs and a 3D viewer for the manual verification. The statistics module offers sample grouping, tests between sample groups and export functionalities, where the results are visualized by heat maps and bar charts. The presented algorithm has been applied to data from a controlled experiment and to biological data, containing analytes distributed over an intensity range of 106. Our approach shows improved sensitivity and an extremely high positive predictive value compared with existing methods. Consequently, the novel algorithm, integrated in a user-friendly application, is a valuable improvement in the high-throughput analysis of the lipidome.
Implementation and availability: The Java application is freely available for non-commercial users at http://genome.tugraz.at/lda. Raw data associated with this manuscript may be downloaded from ProteomeCommons.org Tranche using the following hash: ZBh3nS5bXk6I/Vn32tB5Vh0qnMpVIW71HByFFQqM0RmdF4/4Hcn H3Wggh9kU2teYVOtM1JWwHIeMHqSS/bc2yYNFmyUAAAAAAACl DQ ==
Contact: Gerhard.Thallinger@tugraz.at
Supplementary information: Supplementary data are available from Bioinformatics online.
Multi-level mixed effects models for bead arrays
Authors: Kim Ryung S. , Lin Juan 
Published: December 2010

Abstract
Motivation: Bead arrays are becoming a popular platform for high-throughput expression arrays. However, the number of the beads targeting a transcript and the variation of their intensities differ from sample to sample in these arrays. This property results in different accuracy of expression intensities of a transcript across arrays.
Results: We provide evidence, with publicly available spike-in data, that the false discovery rate of differential expression is reduced by modeling bead-level variability with a multi-level mixed effects model. We compare the performance of our proposed model to existing analysis methods for bead arrays: the unweighted t-test and other weighted methods. Additionally, we provide theoretical insights into when the multi-level mixed effects model outperforms other methods. Finally, we provide a software program for differential expression analysis using the multi-level mixed effects model that analyzes tens of thousands of genes efficiently.
Availability: The software program is freely available on web at http://ephpublic.aecom.yu.edu/sites/rkim/Supplementary.
Contact: ryung.kim@einstein.yu.edu
Supplementary information: Supplementary data are available at Bioinformatics online.
Ocean surface characteristics influence recruitment variability of populations of northern shrimp (Pandalus borealis) in the Northwest Atlantic
Authors: Ouellet Patrick , Fuentes-Yaco César , Savard Louise , Platt Trevor , Sathyendranath Shubha , Koeller Peter , Orr David , Siegstad Helle 
Published: December 2010

Abstract
Ouellet, P., Fuentes-Yaco, C., Savard, L., Platt, T., Sathyendranath, S., Koeller, P., Orr, D., and Siegstad, H. 2011. Ocean surface characteristics influence recruitment variability of populations of northern shrimp (Pandalus borealis) in the Northwest Atlantic. – ICES Journal of Marine Science, 68: 737–744. Remotely sensed data were used to derive simple ecosystem indicators for four regions of the Northwest Atlantic to test the hypothesis that sea surface temperatures (SSTs) and spring phytoplankton bloom characteristics (initiation, timing, intensity, and duration) have a significant influence on larval survival and recruitment of northern shrimp (Pandalus borealis). For all years (1998–2007) and regions, hatching was after the initiation of the bloom and before or after the bloom reached its maximum intensity. The results suggest that the best survival of larvae is associated with high warming rates of SST following hatching, but in very cold environments, warm temperatures at hatching seem to be important for larval survival. The analyses also indicate that larval survival is supported by an early, long phytoplankton bloom which attains high concentrations of chlorophyll a. The results demonstrate the potential of remotely sensed data for deriving simple population-specific ecosystem indicators for potential use in building operational recruitment models for predicting changes in northern shrimp abundance.
Ideal Permissive Hypotension to Resuscitate Uncontrolled Hemorrhagic Shock and the Tolerance Time in Rats
Authors: Li Tao , Zhu Yu , Hu Yi , Li Lijie , Diao Youfang , Tang Jing , Liu Liangming 
Published: December 2010

Background
Studies have shown that permissive hypotension for uncontrolled hemorrhagic shock can result in good resuscitation outcome. The ideal target mean arterial pressure (MAP) and the tolerance time for permissive hypotension have not been determined.

Methods
To elucidate the ideal target MAP and tolerance time for permissive hypotension with uncontrolled hemorrhagic shock rats, the effects of different target MAPs (40, 50, 60, 70, 80, and 100 mmHg) and 60-, 90-, and 120-min permissive hypotension (50 mmHg) on uncontrolled hemorrhagic shock were observed.

Results
Rats in normotensive groups (80 and 100 mmHg) had increased blood loss (101%, 126% of total blood volume), decreased hematocrit, decreased vital organ (liver and kidney) and mitochondrial function, and decreased animal survival rate (1 of 10). Rats in the 50- and 60-mmHg target MAP groups had decreased blood loss (52% and 69%, respectively), good hematocrit and vital organ and mitochondrial function, stable hemodynamics, and increased animal survival (8 of 10 and 6 of 10, respectively). Rats in the 40-mmHg target MAP group, although having decreased blood loss (39%), appeared to have very inferior organ function and animal survival (2 of 10). Animal survival (1 of 10) and vital organ function in the 120-min permissive hypotension group were significantly inferior to the 60- and 90-min groups. The 60- and 90-min groups had similar animal survival (8 of 10 and 6 of 10) and vital organ function.

Conclusion
A target resuscitation pressure of 50-60 mmHg is the ideal blood pressure for uncontrolled hemorrhagic shock. Ninety minutes of permissive hypotension is the tolerance limit; 120 min of hypotensive resuscitation can cause severe organ damage and should be avoided.
Impaired Visual Hand Recognition in Preoperative Patients during Brachial Plexus Anesthesia
Authors: Silva Stein , Loubinoux Isabelle , Olivier Michel , Bataille Benoîmt , Fourcade Olivier , Samii Kamran , Jeannerod Marc , Démonet Jean-Francois 
Published: December 2010

Background
Perceptual illusions described in healthy subjects undergoing regional anesthesia (RA) are probably related to short-term plastic brain changes. We addressed whether performance on an implicit mental rotation task reflects these RA-induced changes in body schema brain representations. Studying these changes in healthy volunteers may shed light on normal function and the central mechanisms of pain.

Methods
Performance pattern was studied in upper limb-anesthetized subjects on a left/right hand judgment task, which is known to involve motor imagery processes relating to hand posture. Three conditions were used: control (i.e., absence of deafferentation), RA (i.e., deafferentation), and vision (i.e., deafferentated limb exposed to view). To limit potential bias such as order effect, the control state was recorded in a randomized manner.

Results
All subjects described perceptual illusions of their anesthetized limb. They were slower and less accurate on the task during RA compared with control. Response patterns were similar in all conditions, suggesting sensitivity of performance to arm/hand biomechanical constraints. Vision was associated with an increase in the proportion of correct responses and a reduction of the response times in hand judgment and was accompanied by disappearance of the lateralization of the underlying mental representations, which was identified during RA.

Conclusions
These results suggest the following: (1) the right/left judgment task involves mental simulation of hand movements, (2) underlying mental representations and their neural substrates are subject to acute alterations after RA, and (3) the proprioceptive deficit induced by RA is influenced by the subject's ability to see the anesthetized limb.
Three‐dimensional modelling of bond behaviour between concrete and FRP reinforcement
Authors: Salomoni Valentina , Mazzucco Gianluca , Pellegrino Carlo , Majorana Carmelo 
Published: December 2010

PurposeThe purpose of this paper is to investigate the bond behaviour between fiber reinforced polymer (FRP) sheets and concrete elements, starting from available experimental evidences, through a calibrated and upgraded 3D mathematical‐numerical model.Design/methodology/approachThe complex mechanism of debonding/peeling failure of FRP reinforcement is studied within the context of damage mechanics to appropriately catch transversal effects and developing a more realistic and comprehensive study of the delamination process. The FE ABAQUS© code has been supplemented with a numerical procedure accounting for Mazars's damage law inside the contact algorithm.FindingsIt has been shown that such an approach is able to catch the delamination evolution during loading processes as well.Originality/valueA Drucker‐Prager constitutive law is adopted for concrete whereas FRP elements are assumed to behave in a linear‐elastic manner, possibly undertaking large strains/displacements. Surface‐to‐surface contact conditions have been applied between FRP and adjacent concrete, including the enhancement given by the strain‐softening law according to Mazars' damage model. The procedure has been introduced to describe the coupled behaviour between concrete, FRP and adhesive resulting in specific bonding‐debonding features under different load levels.
Finite element analysis of delamination of a composite component with the cohesive zone model technique
Authors: Lampani Luca 
Published: December 2010

PurposeThe purpose of this paper is to assess a numerical tool to simulate and predict the onset and the propagation of the delaminations in a composite structure.Design/methodology/approachThe approach to the work is done through the cohesive zone model technique applied to the finite element method.FindingsDouble cantilever beam, end notched flexure and mixed mode bending tests have been performed and correlated to benchmark cases, in order to validate the procedure. Numerical test campaign on specimens of the skirts with delaminations has been performed to analyze the behaviour under compressive load and the buckling.Originality/valueThis tool is applied to the study of the behaviour of some components in carbon/epoxy composite of a space structure in which one or more delaminations are eventually present following impact damage or manufacturing process. The components in particular are the booster's skirts of a small class launcher, subjected to a compressive load.
Analysis of a gravity dam considering the influence of couple‐stresses
Authors: Liu Jun , Huan Ming 
Published: December 2010

PurposeTraditional continuum theory is usually applied in analysis of a gravity dam and its foundation; as we all know, both analytic and numerical solution of traditional theory imply that stress concentration around the dam heel and toe is very severe. However, stress condition of the dam and its foundation seems better for it can work normally for decades. Since concrete masses have macroscopic inhomogeneity, a new model has been built in order to simulate the mechanics behaviour of dam and its foundation rationally as the influence of inhomogeneity of the material has been taken into consideration. The purpose of this paper is to describe the application of the Cosserat granular model to analyze the stress condition of a mass concrete structure.Design/methodology/approachGranular model of Cosserat theory has been built and adopted to model the gravity, considering the influence of the couple‐stresses, due to the inhomogeneity of the material.FindingsThe Cosserat results have been compared with the traditional numerical solution, and the outcome indicates that the distributions of the stresses and displacements are rational, and the stress concentration around dam hell and toe is less severe and closer to the reality when Cosserat theory adopted.Originality/valueThe granular model based on Cosserat theory has been used in modelling a dam body for the first time; because the model can reflect the influence of the inhomogeneity, it is more suitable than traditional continuum model under this condition.
Computer simulation of two‐dimensional linear‐shaped charge jet using smoothed particle hydrodynamics
Authors: Gang Yang , Xu Han , De'an Hu 
Published: December 2010

PurposeThe purpose of this paper is to investigate the formation process of linear‐shaped charge jet using the smoothed particle hydrodynamics (SPH). Different material yield models are embed to test the performance of SPH method in the simulation of explosive driven metal liner. The effects of different ignition model to the formation of metal jet have also been studied.Design/methodology/approachThe SPH method is used with the correction of artificial viscosity and penalty force to simulate the formation process of linear‐shaped charge jet, which includes the process of explosion and interaction between explosive gas and metal liner. The numerical results which got by SPH method are compared with these obtained by mesh‐based method. Different material yield models are implemented in the numerical examples to show the effect of material model to the formation process of metal jet. The single point and two point ignition models are used to study the effect of ignition models to the process of explosion and formation of metal jet.FindingsCompared with the original mesh‐based method, the SPH method can simulate the physical process of linear‐shaped charge jet naturally, as well as the capturing of explosive wave propagation. The implementation of different material yields models to obtain the same formation tendency of metal jet, but some numerical difference exists. In two‐point ignition model the explosive pressure is superimposed at the location that two detonation waves intersect. Compared with two ignition models, the two point ignition model can form the metal jet faster and get the higher velocity metal jet.Originality/valueThere are a few references that address the application of SPH to simulate shaped charge explosion process. The feasibility of the SPH method to simulate the formation process of linear shaped charged jet is tested and verified in this paper. From the results which compared with mesh‐based method, it is shown that the SPH method has the advantage in tracking the large deformation of material and capturing the explosive wave propagation. The SPH method can be selected as a good alternative to traditional mesh‐based numerical methods in simulating similar explosively driven metal material problems which can be referenced from this paper.
The willingness of professionals to contribute to their organisation's certification
Authors: van Kemenade Everard A. , Hardjono Teun W. , de Vries Henk J. 
Published: December 2010

PurposeThis paper seeks to find out which factors influence the willingness of professionals to contribute to a certification process and to understand the rationale behind this willingness.Design/methodology/approachBased on literature, prerequisites are formulated for the willingness of professionals to contribute to certification. These are compared with the results of a study among lecturers at Universities of Applied Sciences in The Netherlands and Flanders about their willingness to contribute to accreditation of their schools. This study combines survey and Delphi research.FindingsProfessionals agree on the added value of certification systems. They are willing to contribute to the certification process, provided that a set of conditions is fulfilled.Research limitations/implicationsThe case focuses on large organisations for which certification is obligatory. The findings may not apply in small or medium‐sized organisations or if the main driver for certification is internal improvement. Further research is needed to verify the generalisation of the results to other sectors and countries.Originality/valueResearch has shown that it is difficult to motivate professionals to contribute to certification. Little research has been done on the reasons why. The paper provides more insight into the difficulties that organizations face to commit their professionals to become involved in certification and turns these into requirements to be fulfilled to achieve commitment. These are relevant for organisations, which need the support of their professional employees to achieve management system certification.
Childhood socioeconomic deprivation and later adulthood health
Authors: Drakopoulos S.A. , Lakioti E. , Theodossiou I. 
Published: December 2010

PurposeAlthough the link between socioeconomic deprivation and health status has been identified by many researchers, not much attention has been paid to the intergenerational effect of poverty on physical and psychological health status. The purpose of this paper is to investigate the effects of childhood deprivation on health at the later stages of the working age.Design/methodology/approachData for individuals aged between 50 and 65 in six European countries are collected using purpose build questionnaires. The dataset provides information on issues such as physical and mental health status, past working experiences, socioeconomic and occupational background, incidence of diseases and sense of well‐being. Ordinary least squares (OLS) and ordered logit models are utilised to estimate the effect of childhood deprivation on health status indices. Logit models are also used to investigate the effects of childhood deprivation on the likelihood of an individual suffering from specific disease.FindingsThere is a consistent and significant negative effect of childhood deprivation on the overall health profile at later adulthood. For instance, for each additional unit of the childhood deprivation index, the index of the mobility status and physical health status in later adulthood decrease by 0.19 and 0.28, respectively, the index of the psychological health decrease by almost 0.41 and the odds of exhibiting better self‐assessed health decrease by a factor of 0.86 (all p‐values are <0.01). Similar negative effects of childhood deprivation on the likelihood of an individual suffering from a specific medical condition are unearthed.Originality/valueIt is shown that childhood socioeconomic deprivation has long lasting detrimental effects on the health of individuals that are observable at the later ages of working life. Hence, the relationship between childhood socioeconomic deprivation and adult health should be an important factor in social policy and health care planning in an era of aging populations.