bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seasonal migration pattern of an important rice pest, Nilaparvata lugens (Hemiptera: Delphacidae), on Hainan Island, China
Authors: Gu Fuxiong , Lu Hui , Lyu Baoqian , Zhang Qikai , Jiao Bin , Tang Jihong 
Published: April 2024

Abstract
The brown planthopper, Nilaparvata lugens (Hemiptera: Delphacidae) (BPH), is a major, regionally migratory pest of rice in Asia. Despite intensive migratory studies, the seasonal migratory pattern of this species in the year-round breeding region (i.e., Hainan Island) remains largely unknown. To understand the migration dynamics, we conducted relevant research based on BPH light trap catches on Hainan in 2017–2022. Results showed that the occurrence dynamics of BPH in Hainan oscillated in different years and seasons. Overall, there are 4 migration peak periods on Hainan, with outbound peak periods in April–May and August–September and inbound peak periods in June and October. Trajectory and wind fields showed that in August–September, Hainan had complex meteorological conditions, and the outbound paths of BPH were variable, mainly landing in southeastern Guangxi and southwestern Guangdong. In contrast, April–May was influenced by southeasterly winds, with a wider outbound range and a further distance, landing along northeastern Vietnam from west to east toward Guangxi and Guangdong areas with time. Wind-rain fields, trajectory, and hydrogen isotope showed that in June, southwesterly winds transported BPH northward from the Indochina peninsula, where it was hindered by rainfall in the Leizhou Peninsula area and the migrants will be “rained out” into Hainan. Identically, in October, the interactions between northeasterly winds and rainfall belts on the southwest shore of Hainan increased the opportunities for BPH to migrate southward to reach Hainan. Our results suggest that Hainan is not only an important source of BPH migrating from East Asia but also plays the role of a bridge.
Not just for lymphoid cells: the role of the noncanonical NF-κB signaling pathway in early and late myelopoiesis with a focus on hypereosinophilic disorders
Authors: Trusiano Brie , Zimmerman Kurt L , Morrison Holly A , Allen Irving C 
Published: April 2024

Abstract
The noncanonical NF-κB pathway is involved in lymphoid organ development, B-cell maturation, and cytokine production. However, new research has demonstrated that this pathway is also key for the orderly and sequential maturation of myeloid cells, including neutrophils and eosinophils. When this pathway is disrupted or constitutively activated, aberrations in hematopoietic stem and progenitor cell survival and proliferation, as well as subsequent granulopoiesis and eosinophilopoiesis, are affected. Disturbance of such a coordinated and delicate process can manifest in devastating clinical disease, including acute and chronic myeloid leukemias, preleukemic processes such as myelodysplastic syndrome, or hyperinflammatory conditions like hypereosinophilic syndrome. In this review, we discuss the molecular machinery within the noncanonical NF-κB pathway, crosstalk with the canonical NF-κB pathway, murine models of noncanonical signaling, and how aberrations in this pathway manifest in leukemic or hyperinflammatory disease with a focus on hypereosinophilic syndrome. Potential and promising drug therapies will also be discussed, emphasizing the noncanonical NF-κB pathway as a potential target for improved treatment for patients with leukemia or idiopathic hypereosinophilic syndrome. The hope is that review of such mechanisms and treatments may eventually result in findings that aid physicians in rapidly diagnosing and more accurately classifying patients with such complex and overlapping hematopoietic diseases.
The regenerative liminalities of Global Citizenship Education
Authors: Palmer Nicholas 
Published: April 2024

Abstract
Global citizenship education (GCE) is an active entanglement in the civic priorities of the planet. In recent research, the concept has emerged as a multivalent coalescence of being, an engagement with planetary tensions and revisions of cosmopolitan ideology. In this article, I argue for a theoretical interpretation of GCE reliant on liminal-oriented practice and the potentialities of regenerative agency. Privileging Axel Honneth’s interpretation of social freedom and Boaventura de Sousa Santos’ postabyssal thinking, I argue that interfaces with the limit of our global perception reveal the regenerative qualities of our relations, allowing us to conceive ourselves as uniquely influenced by globality and possessing critical agency for otherness. Although such global perceptions can only ever be wrought within the ideological constraints of locality, a globally situated agency is more agile as a regenerative set of dispositions and interknowledge ‘globalities’. I further argue that regenerative liminalities hold significant implications for teaching and learning, as they signify the importance of a global consciousness over a technologically rationalized competency-based approach.
When digitalization hit the court: Strategizing to turn turbulence into opportunities
Authors: Kronblad Charlotta , Pregmark Johanna Envall 
Published: April 2024

Abstract
During Covid-19, the pace of digitalization in industry and society increased. This article zooms in on the court system in Sweden and its response to this rapidly changing context. During the pandemic, the courts had encountered new expectations, and digital technologies had been implemented at speed. Suddenly online trials and digital delivery of court services became a reality. When the pandemic eased questions arose whether to return to business-as-usual or to continue on the new digital path. This article builds on a series of strategic workshops performed at the Swedish courts 2020–23 (with a total of 200 professionals attending). We found that digitalization had affected core work processes as well as the mindset and culture for further change. However, strategic alignment of different organizational components to fit the new reality is still needed in order for the courts to keep, and develop, the largest gains from digitalization: flexibility, efficiency, and accessibility.
A recombinant plasmid encoding human hepatocyte growth factor promotes healing of combined radiation-trauma skin injury involved in regulating Nrf2 pathway in mice
Authors: Li Dujuan , Lu Yuxin , Xiao Fengjun , Cheng Xiaochen , Hu Chunsheng , Zhu Xuefeng , Wang Xiaoying , Duan Haiying , Du Li , Zhang Qinglin 
Published: April 2024

AbstractCombined radiation-trauma skin injury represents a severe and intractable condition that urgently requires effective therapeutic interventions. In this context, hepatocyte growth factor (HGF), a multifunctional growth factor with regulating cell survival, angiogenesis, anti-inflammation and antioxidation, may be valuable for the treatment of combined radiation-trauma injury. This study investigated the protective effects of a recombinant plasmid encoding human HGF (pHGF) on irradiated human immortalized keratinocytes (HaCaT) cells in vitro, and its capability to promote the healing of combined radiation-trauma injuries in mice. The pHGF radioprotection on irradiated HaCaT cells in vitro was assessed by cell viability, the expression of Nrf2, Bcl-2 and Bax, as well as the secretion of inflammatory cytokines. In vivo therapeutic treatment, the irradiated mice with full-thickness skin wounds received pHGF local injection. The injuries were appraised based on relative wound area, pathology, immunohistochemical detection, terminal deoxynucleotidyl transferase dUTP nick end labelling assay and cytokine content. The transfection of pHGF increased the cell viability and Nrf2 expression in irradiated HaCaT cells. pHGF also significantly upregulated Bcl-2 expression, decreased the Bax/Bcl-2 ratio and inhibited the expression of interleukin-1β and tumor necrosis factor-α in irradiated cells. Local pHGF injection in vivo caused high HGF protein expression and noticeable accelerated healing of combined radiation-trauma injury. Moreover, pHGF administration upregulated Nrf2, vascular endothelial growth factor, Bcl-2 expression, downregulated Bax expression and mitigated inflammatory response. In conclusion, the protective effect of pHGF may be related to inhibiting apoptosis and inflammation involving by upregulating Nrf2. Local pHGF injection distinctly promoted the healing of combined radiation-trauma injury and demonstrates potential as a gene therapy intervention for combined radiation-trauma injury in clinic.
SMART: spectral energy distributions Markov chain analysis with radiative transfer models
Authors: Varnava Charalambia , Efstathiou Andreas 
Published: April 2024

ABSTRACT
In this paper we present the publicly available open-source spectral energy distribution (SED) fitting code SMART (Spectral energy distributions Markov chain Analysis with Radiative Transfer models). Implementing a Bayesian Markov chain Monte Carlo (MCMC) method, SMART fits the ultraviolet to millimetre SEDs of galaxies exclusively with radiative transfer models that currently constitute four types of pre-computed libraries, which describe the starburst, active galactic nucleus (AGN) torus, host galaxy, and polar dust components. An important novelty of SMART is that, although it fits SEDs exclusively with radiative transfer models, it takes comparable time to popular energy balance methods to run. Here we describe the key features of SMART and test it by fitting the multiwavelength SEDs of the 42 local ultraluminous infrared galaxies (ULIRGs) that constitute the HERschel Ultraluminous Infrared Galaxy Survey (HERUS) sample. The Spitzer spectroscopy data of the HERUS ULIRGs are included in the fitting at a spectral resolution, which is matched to that of the radiative transfer models. We also present other results that highlight the performance and versatility of SMART. SMART promises to be a useful tool for studying galaxy evolution in the JWST era. SMART is developed in Python and is available at https://github.com/ch-var/SMART.git.
Tracing the green valley with entropic thresholding
Authors: Pandey Biswajit 
Published: April 2024

ABSTRACT
The green valley represents the population of galaxies that are transitioning from the actively star-forming blue cloud to the passively evolving red sequence. Studying the properties of the green valley galaxies is crucial for our understanding of the exact mechanisms and processes that drive this transition. The green valley does not have a universally accepted definition. The boundaries of the green valley are often determined by empirical lines that are subjective and vary across studies. We present an unambiguous definition of the green valley in the colour–stellar mass plane using the entropic thresholding. We first divide the galaxy population into the blue cloud and the red sequence based on a colour threshold that minimizes the intraclass variance and maximizes the interclass variance. Our method splits the region between the mean colours of the blue cloud and the red sequence into three parts by maximizing the total entropy of that region. We repeat our analysis in a number of independent stellar mass bins to define the boundaries of the green valley in the colour–mass diagram. Our method provides a robust and natural definition of the green valley.
A dusty protocluster surrounding the binary galaxy HerBS-70 at z = 2.3
Authors: Bakx Tom J L C , Berta S , Dannerbauer H , Cox P , Butler K M , Hagimoto M , Hughes D H , Riechers D A , van der Werf P P , Yang C , Baker A J , Beelen A , Bendo G J , Borsato E , Buat V , Cooray A R , Dunne L , Dye S , Eales S , Gavazzi R , Harris A I , Ismail D , Ivison R J , Jones B , Krips M , Lehnert M D , Marchetti L , Messias H , Negrello M , Neri R , Omont A , Perez-Fournon I , Nanni A , Chartab N , Serjeant S , Stanley F , Tamura Y , Urquhart S A , Vlahakis C , Weiß A , Young A J 
Published: April 2024

ABSTRACT
We report on deep SCUBA-2 observations at 850 $\mu$m and NOrthern Extended Millimetre Array (NOEMA) spectroscopic measurements at 2 mm of the environment surrounding the luminous, massive (M* ≈ 2 × 1011 M⊙) Herschel-selected source HerBS-70. This source was revealed by previous NOEMA observations to be a binary system of dusty star-forming galaxies at z = 2.3, with the east component (HerBS-70E) hosting an active galactic nucleus. The SCUBA-2 observations detected, in addition to the binary system, 21 sources at &gt;3.5σ over an area of ∼25 square comoving Mpc with a sensitivity of 1σ850 = 0.75 mJy. The surface density of continuum sources around HerBS-70 is three times higher than for field galaxies. The NOEMA spectroscopic measurements confirm the protocluster membership of three of the nine brightest sources through their CO(4–3) line emission, yielding a volume density 36 times higher than for field galaxies. All five confirmed sub-mm galaxies in the HerBS-70 system have relatively short gas depletion times (80−500 Myr), indicating the onset of quenching for this protocluster core due to the depletion of gas. The dark matter halo mass of the HerBS-70 system is estimated around 5 × 1013 M⊙, with a projected current-day mass of 1015 M⊙, similar to the local Virgo and Coma clusters. These observations support the claim that DSFGs, in particular the ones with observed multiplicity, can trace cosmic overdensities.
Time-dependent AGN disc winds – I. X-ray irradiation
Authors: Dyda Sergei , Davis Shane W , Proga Daniel 
Published: April 2024

ABSTRACT
We study active galactic nucleus (AGN) line-driven disc winds using time-dependent radiation hydrodynamics. The key criterion for determining wind launching is the coupling strength of the ultraviolet radiation field via the spectral lines of the gas. The strength of these lines in turn relies crucially on the gas ionization state, determined by the local X-ray intensity. We consider a suite of models where the central ionizing radiation is affected by scattering, absorption, and re-emission by the intervening gas. In a pure attenuation model, the disc launches an episodic wind, as previous studies have shown. Including scattering or re-emission tends to weaken the wind, lowering the mass flux and outflow velocity and, if sufficiently dominant, suppressing the outflow entirely. However, the exponential nature of radiative attenuation means that only a modest, factor of a few, increase in the absorption cross-section can overcome the wind suppression due to scattering and re-emission. We find mass outflow rates of ∼20 per cent or more of the assumed inflow rate through the disc, indicating that radiation-driven winds may significantly alter the structure of the accretion flow. The winds also supply a large, time-varying column of material above the nominal constant disc scale height, which will determine the geometry of reprocessed emission from the central source. Our results suggest the need for accurate photoionization modelling, radiation transport, and accretion disc physics, to study their effects on the AGN disc winds.
Viral SARS-CoV-2 Rebound Rates in Linked Commercial Pharmacy-Based Testing and Health Care Claims
Authors: Kelly Scott P , McEwen Lisa M , Isaksson Magnus , Murphy Sarah , White Simon , Levy Matthew E , McCrone John T , Levan Geraint , Santhanam Sharad , Baniecki Mary Lynn , Bramson Candace , Rubino Heather , Hendrick Vicky , Soares Holly , Hammond Jennifer , Luo Shishi 
Published: April 2024

Abstract

Background
Viral SARS-CoV-2 rebound (viral RNA rebound) is challenging to characterize in large cohorts due to the logistics of collecting frequent and regular diagnostic test results. Pharmacy-based testing data provide an opportunity to study the phenomenon in a large population, also enabling subgroup analyses. The current real-world evidence approach complements approaches focused on smaller, prospective study designs.

Methods
We linked real-time reverse transcription quantitative polymerase chain reaction test data from national pharmacy-based testing to health care claims data via tokenization to calculate the cumulative incidence of viral RNA rebound within 28 days following positive test results in nirmatrelvir/ritonavir (NMV-r)–treated and untreated individuals during the Omicron era (December 2021–November 2022) and prior to the Omicron era (October 2020–November 2021).

Results
Among 30 646 patients, the rate of viral RNA rebound was 3.5% (95% CI, 2.0%–5.7%) in NMV-r–treated infections as compared with 1.5% (95% CI, 1.3%–1.7%) in untreated infections during the Omicron era and 1.9% (95% CI, 1.7%–2.1%) prior to the Omicron era. Viral RNA rebound in patients who were vaccinated (n = 8151), high risk (n = 4411), or older (≥65 years, n = 4411) occurred at comparable rates to the overall cohort (range, 1.1%–4.8%). Viral rebounds to high RNA levels in NMV-r–treated infections occurred in 8% of viral rebounds as compared with 5% to 11% in untreated infections. Rates of hospitalization were comparable between patients with NMV-r–treated infections with viral RNA rebound (0%) and untreated patients with viral RNA rebound (0%–1.2%).

Conclusions
Our findings suggest viral RNA rebound is rare (&lt; 5%), with rates that were consistent with those from the EPIC-HR trial (Evaluation of Protease Inhibition for COVID-19 in High-Risk Patients). Most occurrences of viral RNA rebound were associated with low viral RNA levels, and viral RNA rebound progression to severe disease was not observed.
Seigneurial predation in the late medieval feud
Authors: Sharp Tristan W 
Published: April 2024

Abstract
This article challenges the ‘from-lordship-to-government’ model of the grand narrative of European state formation through a reconceptualization of the late medieval German feud and lordship (1300–1500). It demonstrates how the predatory lordship of the feudal revolution persisted in late medieval imperial lands by centring on how modalities of extractive violence linked the lordly feud and lordship together in a system of seigneurial violence. It thus returns to Gadi Algazi’s controversial thesis that seigneurial lordship was a protection racket enabled by the omnipresent potential of the feud’s lordly violence. The author proposes that an overlooked body of evidence, damage registers (Schadensverzeichnisse), provides the evidence necessary for confirming and broadening Algazi’s insights. Through an archival collection of these documents, the author elucidates how this late medieval system of seigneurial violence was typified by a continuum of extractive violence from plundering to the levying of tribute and protection. In doing so, the author highlights how this system of seigneurial violence, lordship, and late medieval advances in governance held the potential to work together in far more complex ways than the ‘from-lordship-to-government’ narrative acknowledges.
Neuroinflammation generated by HIV-infected microglia promotes dysfunction and death of neurons in human brain organoids
Authors: Kong Weili , Frouard Julie , Xie Guorui , Corley Michael J , Helmy Ekram , Zhang Gang , Schwarzer Roland , Montano Mauricio , Sohn Peter , Roan Nadia R , Ndhlovu Lishomwa C , Gan Li , Greene Warner C 
Published: April 2024

Abstract
Despite the success of combination antiretroviral therapy (ART) for individuals living with HIV, mild forms of HIV-associated neurocognitive disorder (HAND) continue to occur. Brain microglia form the principal target for HIV infection in the brain. It remains unknown how infection of these cells leads to neuroinflammation, neuronal dysfunction, and/or death observed in HAND. Utilizing two different inducible pluripotent stem cell-derived brain organoid models (cerebral and choroid plexus [ChP] organoids) containing microglia, we investigated the pathogenic changes associated with HIV infection. Infection of microglia was associated with a sharp increase in CCL2 and CXCL10 chemokine gene expression and the activation of many type I interferon stimulated genes (MX1, ISG15, ISG20, IFI27, IFITM3 and others). Production of the proinflammatory chemokines persisted at low levels after treatment of the cell cultures with ART, consistent with the persistence of mild HAND following clinical introduction of ART. Expression of multiple members of the S100 family of inflammatory genes sharply increased following HIV infection of microglia measured by single-cell RNA-seq. However, S100 gene expression was not limited to microglia but was also detected more broadly in uninfected stromal cells, mature and immature ChP cells, neural progenitor cells and importantly in bystander neurons suggesting propagation of the inflammatory response to bystander cells. Neurotransmitter transporter expression declined in uninfected neurons, accompanied by increased expression of genes promoting cellular senescence and cell death. Together, these studies underscore how an inflammatory response generated in HIV-infected microglia is propagated to multiple uninfected bystander cells ultimately resulting in the dysfunction and death of bystander neurons.
Dual stimulus-responsive renewable nanoadsorbent for selective adsorption of low-density lipoprotein in serum
Authors: Guo Chen , Jiang Xinbang , Guo Xiaofang , Liu Zhuang , Wang Biao , Du Yunzheng , Tian Ziying , Wang Zimeng , Ou Lailiang 
Published: April 2024

Abstract
Selective removal of ultra-high low-density lipoprotein (LDL) from the blood of hyperlipemia patients using hemoperfusion is considered an efficient method to prevent the deterioration of atherosclerotic cardiovascular disease. Based on the exceptional structure–function properties of multistimulus-responsive materials, we developed a magnetic photorenewable nanoadsorbent (Fe3O4@SiO2@Azo-COOH) with outstanding selectivity and regenerative characteristics, featuring functionalized azobenzene as the ligand. The dual-stimulus response endowed Fe3O4@SiO2@Azo-COOH with rapid separation and photoregenerative properties. The adsorbent demonstrated excellent removal efficiency of LDL with an adsorption capacity of 15.06 mg/g, and highly repetitive adsorption performance (≥5 cycles) under irradiation. Fe3O4@SiO2@Azo-COOH also exhibited remarkable adsorption properties and selectivity in human serum, with adsorption capacities of 10.93, 21.26 and 9.80 mg/g for LDL, total cholesterol and triglycerides and only 0.77 mg/g for high-density lipoprotein (HDL), resulting in a 93% selective adsorption difference (LDL/HDL). Complete green regeneration of the nanoadsorbent was achieved through a simple regeneration process, maintaining a recovery rate of 99.4% after five regeneration experiments. By combining dynamic perfusion experiment with micromagnetic microfluidics, the LDL content decreased by 16.6%. Due to its superior adsorption capacity and regenerative properties, the dual stimulus-responsive nanosorbent is considered a potential hemoperfusion adsorbent.
Identifying the mass—a timely reminder from Hong Kong Court
Authors: Lam Steven 
Published: April 2024

Abstract
In Hip Hing Construction Co Ltd v Hong Kong Airlines Ltd [2024] HKCFI 370, [2024] HKCLC 83, the Hong Kong Court of First Instance held that a clause purporting to create a trust of a sum of money over the defendant’s general assets was void for uncertainty of subject-matter. This note seeks to examine the significance of the Court’s reasoning. In particular, it argues that the Court’s express endorsement of the beneficial co-ownership analysis when analysing the question of certainty of subject-matter is to be welcomed. The Court correctly highlighted the importance of identifying the “mass”, of which the trust asset forms part. The “mass” or the “single asset” must be identified before the beneficiary could acquire an equitable interest as an equitable tenant-in-common.