bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporal organization of narrative recall is present but attenuated in adults with hippocampal amnesia
Authors: Evans Melissa J. , Clough Sharice , Duff Melissa C. , Brown‐Schmidt Sarah 
Published: June 2024

AbstractStudies of the impact of brain injury on memory processes often focus on the quantity and episodic richness of those recollections. Here, we argue that the organization of one's recollections offers critical insights into the impact of brain injury on functional memory. It is well‐established in studies of word list memory that free recall of unrelated words exhibits a clear temporal organization. This temporal contiguity effect refers to the fact that the order in which word lists are recalled reflects the original presentation order. Little is known, however, about the organization of recall for semantically rich materials, nor how recall organization is impacted by hippocampal damage and memory impairment. The present research is the first study, to our knowledge, of temporal organization in semantically rich narratives in three groups: (1) Adults with bilateral hippocampal damage and severe declarative memory impairment, (2) adults with bilateral ventromedial prefrontal cortex (vmPFC) damage and no memory impairment, and (3) demographically matched non‐brain‐injured comparison participants. We find that although the narrative recall of adults with bilateral hippocampal damage reflected the temporal order in which those narratives were experienced above chance levels, their temporal contiguity effect was significantly attenuated relative to comparison groups. In contrast, individuals with vmPFC damage did not differ from non‐brain‐injured comparison participants in temporal contiguity. This pattern of group differences yields insights into the cognitive and neural systems that support the use of temporal organization in recall. These data provide evidence that the retrieval of temporal context in narrative recall is hippocampal‐dependent, whereas damage to the vmPFC does not impair the temporal organization of narrative recall. This evidence of limited but demonstrable organization of memory in participants with hippocampal damage and amnesia speaks to the power of narrative structures in supporting meaningfully organized recall despite memory impairment.
White wine vinification and an expanded insight into pellicular macerations: bibliometric and bibliographic review
Authors: dos Santos José Ricardo Machado , Kempka Aniela Pinto 
Published: June 2024

AbstractBACKGROUNDPellicular macerations in the vinification of white wines involve the contact of grape skins and seeds with the must before, during or after alcoholic fermentation. Pre‐fermentative pellicular maceration aims to enrich the must with volatile compounds and aroma precursors. Fermentative maceration occurs during alcoholic fermentation, whereas post‐fermentative maceration is carried out after this process, associated with orange, amber or skin‐contact wines, which have experienced a growing global demand in recent years. In this context, this research aimed to conduct a bibliometric review on pellicular macerations in white wines using two search strategies on the specific platform for the period from 2010 to 2023. Additionally, we sought to identify research trends in this segment of the wine industry through a comprehensive literature review of the retrieved documents.RESULTSThe results emphasized more studies on pre‐fermentative pellicular maceration than on long‐duration macerations during and after alcoholic fermentation. Alternative maceration techniques, such as grape freezing, were also observed as study subjects, including their effects on final wines. The research identified a wide variety of grapes explored in studies related to pellicular macerations of the Vitis vinifera L. species, with approximately 50 distinct nomenclatures identified. Regarding pre‐fermentative macerations, the contact time varied from 2 to 60 h, with the temperature range 1–20 °C.CONCLUSIONThe specific search for extended skin contact white wines revealed a limited number of available documents, indicating that studies related to this product style are promising and necessary, given the growing commercial relevance of this product profile. © 2024 Society of Chemical Industry.
Adjuvant chemotherapy versus preoperative chemotherapy for gastric cancer treated with curative‐intent resection: A propensity score‐matched analysis
Authors: Pereira Marina Alessandra , Ramos Marcus Fernando Kodama Pertille , Dias Andre Roncon , Yagi Osmar Kenji , Charruf Amir Zeide , de Castria Tiago Biachi , Ribeiro Ulysses 
Published: June 2024

AbstractBackgroundMultimodal therapy (MMT), comprising surgery alongside perioperative chemotherapy (PCMT) or adjuvant chemotherapy (ACMT), has demonstrated improve in survival compared with surgery alone for advanced gastric cancer (GC). However, the moment of administering chemotherapy for GC is still a matter of debate. This study aimed to compare PCMT and ACMT in patients with locally advanced GC.MethodWe included all gastric adenocarcinoma treated with chemotherapy and curative‐intent resection. Using propensity score matching (PSM), patients who received PCMT were matched with patients undergoing ACMT for 10 pretreatment variables.ResultsAmong the 552 patients with indication for MMT, 377 (68.3%) received combining chemotherapy (CMT): 116 (30.8%) PCMT and 261 (69.2%) ACMT. After PSM, 109 patients were matched in each group. All variables assigned in the score were well matched and both groups became equivalent. Patients receiving PCMT had less angiolymphatic and perineural invasion, less advanced pT, pN and pTNM stage than ACMT group (p < 0.001 for all). There was no difference in the postoperative complication rate between both groups (p = 0.551). After the matching, disease‐free survival (DFS) and overall survival (OS) became similar between PCMT and ACMT groups (DFS: 51.4% vs. 46.9%, p = 0.882, respectively; OS: 54.3% vs. 48.7%, p = 0.638, respectively).ConclusionAfter controlling for pretreatments characteristics, there was no significant difference in survival between GC patients who underwent perioperative and adjuvant CMT. PCMT did not result in an increase in survival, but it provides a decrease in the stage of the disease, with no difference in surgical outcomes.
Modeling the liquid‐liquid chromatography separation of cannabinoids from hemp extracts
Authors: Luca Simon Vlad , Gerigk Melanie , Arshad Ahmad Adeel , Minceva Mirjana 
Published: June 2024

The separation of cannabinoids from hemp materials is nowadays one of the most promising industrial applications of liquid‐liquid chromatography (LLC). Despite various experimental research efforts to purify cannabinoids, there are currently few works on process modeling. Thus, this study aimed to explore a straightforward approach to model the LLC separation of cannabinoids from two hemp extracts with different compositions. The feed materials were simplified to mixtures of preselected key components (i.e., cannabidiol, tetrahydrocannabinol, cannabigerol, and cannabinol). The elution profiles of cannabinoids were simulated using the equilibrium‐cell model with an empirical nonlinear correlation. The model parameters were derived from the elution profiles of single‐solute pulse injections. For the validation of the proposed approach, LLC separations with the two hemp extracts were performed in descending mode with the solvent system composed of hexane/methanol/water 10/8/2 (v/v/v). The injected sample concentrations were gradually increased from 5 to 100 mg/mL. The results showed that the approach could describe reasonably well the elution behavior of the cannabinoids, with deviations of only 1–2 min between simulated and experimental elution times. However, to improve the prediction accuracy, the model parameters can be refitted to the elution profiles of 3–4 systematically selected pulse injections with specific hemp extracts.
Atomistic Molecular Dynamics Simulations of ABA‐Type Polymer Peptide Conjugates: Insights into Supramolecular Structures and their Circular Dichroism Spectra
Authors: Obenauer Moritz L. , Dresel Johannes A. , Schweitzer Maren , Besenius Pol , Schmid Friederike 
Published: June 2024

AbstractA combination of atomistic molecular dynamics (aMD) simulations and circular dichroism (CD) analysis is used to explore supramolecular structures of amphiphilic ABA‐type triblock polymer peptide conjugates (PPC). Using the example of a recently introduced PPC with pH‐ and temperature responsive self‐assembling behavior [Otter et al., Macromolecular Rapid Communications2018, 39, 1800459], this study shows how molecular dynamics simulations of simplified fragment molecules can add crucial information to CD data, which helps to correctly identify the self‐assembled structures and monitor the folding/unfolding pathways of the molecules. The findings offer insights into the nature of structural transitions induced by external stimuli, thus contributing to the understanding of the connection of microscopic structures with macroscopic properties.
Heat and momentum losses in $${\text {H}}_{2}$$–$${\text {O}}_{2}$$–$${\text {N}}_{2}/{\textrm{Ar}}$$ detonations: on the existence of set-valued solutions with detailed thermochemistry
Authors: Veiga-López F. , Faria L. , Melguizo-Gavilanes J. 
Published: June 2024

AbstractThe effect of heat and momentum losses on the steady solutions admitted by the reactive Euler equations with sink/source terms is examined for stoichiometric hydrogen–oxygen mixtures. Varying degrees of nitrogen and argon dilution are considered in order to access a wide range of effective activation energies, $$E_{\textrm{a,eff}}/R_{\textrm{u}}T_{0}$$

E
a,eff

/

R
u

T
0

, when using detailed thermochemistry. The main results of the study are discussed via detonation velocity-friction coefficient (D–$$c_{\textrm{f}}$$

c
f

) curves. The influence of the mixture composition is assessed, and classical scaling for the prediction of the velocity deficits, $$D(c_{\textrm{f,crit}})/D_{\textrm{CJ}}$$

D

(

c
f,crit

)

/

D
CJ

, as a function of the effective activation energy, $${E}_{\textrm{a,eff}}/R_{\textrm{u}} T_{0}$$

E
a,eff

/

R
u

T
0

, is revisited. Notably, a map outlining the regions where set-valued solutions exist in the $$E_{\textrm{a,eff}}/R_{\textrm{u}}T_{0}\text {--}{\alpha }$$

E
a,eff

/

R
u

T
0

--
α

space is provided, with $$\alpha $$
α
denoting the momentum–heat loss similarity factor, a free parameter in the current study.
Meningioma grading via diagnostic imaging: A systematic review and meta-analysis
Authors: Upreti Tushar , Dube Sheen , Pareek Vibhay , Sinha Namita , Shankar Jai 
Published: June 2024

Abstract
Purpose
Meningioma is the most common intracranial tumor, graded on pathology using WHO criteria to predict tumor course and treatment. However, pathological grading via biopsy may not be possible in cases with poor surgical access due to tumor location. Therefore, our systematic review aims to evaluate whether diagnostic imaging features can differentiate high grade (HG) from low grade (LG) meningiomas as an alternative to pathological grading.

Methods
Three databases were searched for primary studies that either use routine magnetic resonance imaging (MRI) or computed tomography (CT) to assess pathologically WHO-graded meningiomas. Two investigators independently screened and extracted data from included studies.

Results
24 studies met our inclusion criteria with 12 significant (p < 0.05) CT and MRI features identified for differentiating HG from LG meningiomas. Cystic changes in the tumor had the highest specificity (93.4%) and irregular tumor-brain interface had the highest positive predictive value (65.0%). Mass effect had the highest sensitivity (81.0%) and negative predictive value (90.7%) of all imaging features. Imaging feature with the highest accuracy for identifying HG disease was irregular tumor-brain interface (79.7%). Irregular tumor-brain interface and heterogenous tumor enhancement had the highest AUC values of 0.788 and 0.703, respectively.

Conclusion
Our systematic review highlight imaging features that can help differentiate HG from LG meningiomas.
The Modified Superomedial Pedicle Breast Reduction Technique for Cases with SN–N Distance Exceeding 33 cm
Authors: Panopoulou Georgina , Petrou Ilias , Savva Demetris , Vassiliou Andreas 
Published: June 2024

Abstract

Background
Symptomatic breast hypertrophy affects the quality of life of a large number of women globally. Many reduction mammoplasty techniques have been described for patients with breast hypertrophy. The aim of this study was to provide our clinic’s experience in utilizing the modified superomedial pedicle breast reduction technique in specific patients suffering from breast hypertrophy, with sternal notch-to-nipple distance of more than 33 cm.

Method
Our study included twenty patients who underwent, from January 2022 to December 2023, the modified superomedial pedicle breast reduction technique due to symptomatic breast hypertrophy with sternal notch-to-nipple distance of more than 33 cm in the Plastic and Reconstructive Surgery Department at Nicosia General Hospital in Cyprus. Patient demographics, comorbidities, pre- and postoperative breast anthropometric measurements and surgical complications were recorded and analyzed.

Results
The average age at the time of the reduction was 48 years. The mean preoperative body mass index was 28.52 kg/m2. Patients’ comorbidities included one (5%) patient with diabetes, seven (35%) with obesity and three (15%) with hypertension. The mean preoperative sternal notch-to-nipple distance was 35.25 cm for the right breast and 34.90 cm for the left breast, while the mean postoperative was 20.65 cm for both breasts. The total mean resection weight of both breasts was 1643.45 g. Surgical complications were minor including two (10%) cases of local hematoma and one (5%) case of T-Junction wound breakdown. All patients were relieved from their preoperative symptoms and were satisfied with the final result.

Conclusion
Our modified superomedial pedicle technique is a safe, effective and versatile pedicle to be used with many advantages, in specific patients suffering from breast hypertrophy with sternal notch-to-nipple distance of more than 33 cm, including its shape and rotational abilities, viability of the nipple and excellent outcome of glandular plication and breast reshaping.

Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Imaging features for the identification of atrial fibrillation in cryptogenic stroke patients
Authors: Lambert Anna Tancin , Sætre Dag Ottar , Ratajczak-Tretel Barbara , Gleditsch Jostein , Høie Gudrun , Al-Ani Riadh , Pesonen Maiju , Atar Dan , Aamodt Anne Hege 
Published: June 2024

Abstract
Background
Whether specific imaging aspects can be used to identify cryptogenic stroke (CS) patients with high risk of underlying atrial fibrillation (AF) remains unclear. The purpose of this study was to evaluate brain-imaging features in CS patients and their utility as AF predictors.

Methods
The Nordic Atrial Fibrillation and Stroke study was a prospective observational study of CS and transient ischemic attack patients undergoing 12-month cardiac-rhythm monitoring, biomarker and clinical assessments. In this imaging sub-study, brain magnetic resonance imaging and computed tomography scans from 106 patients were assessed for acute and chronic ischemic lesions in relation to AF occurrence and included in a score to predict AF. Receiver operating characteristics (ROC) curve was used to evaluate the discriminative ability of the score and for its dichotomization for predictive model.

Results
Age, periventricular white-matter hyperintensities (PVWMH), acute lesion size, and vessel occlusion were significantly associated with AF. Acute and chronic cortical infarcts as well as chronic cerebellar infarcts were numerically more frequent in the AF group than the non-AF group. A score consisting of six features (0–6 points) was proposed (age ≥ 65 years, chronic cortical or cerebellar lesions, acute cortical lesions, PVWMH ≥ 2 in Fazekas scale, vessel occlusion, and acute lesion size ≥ 10 mm). Area under ROC curve was 0.735 and a score of ≥ 3 points was a predictor of AF.

Conclusions
The suggested score was shown to identify CS patients with an increased risk of underlying AF.
Anemia and iron metabolism disorders after single anastomosis sleeve ileal (SASI) bypass. Is it a real problem?
Authors: Parkitna Joanna , Binda Artur , Gonciarska Agnieszka , Jaworski Paweł , Kudlicka Emilia , Barski Krzysztof , Wawiernia Karolina , Jankowski Piotr , Wąsowski Michał , Kuryłowicz Alina , Tarnowski Wiesław 
Published: June 2024

Abstract
Purpose
SASI (single anastomosis sleeve ileal) bypass can lead to nutritional deficiencies, including disorders of iron metabolism and anemia. This study aims to evaluate the effect of SASI bypass on weight loss, anemia, and iron deficiency in patients with obesity during the follow-up period.

Methods
This study is a retrospective analysis of prospectively collected data from patients who underwent SASI bypass at our hospital between January 2020 and February 2022.

Results
The mean age of the patients was 42 years (range 22–58). The average duration of the follow-up period was 26 months. The mean percentage of excess weight loss (%EWL) was 90.1%, and total weight loss (%TWL) was 30.5%. During the postoperative observation period, anemia was identified in ten patients (25%), comprising 70% with normocytic anemia, 10% with microcytic anemia, and two macrocytic anemia cases (20%). Iron deficiency was observed in two patients (5%).

Conclusion
SASI bypass is an effective bariatric procedure in weight loss outcomes. However, there may be an increased risk of anemia and iron metabolism disruptions associated with this procedure. The common limb length (250 vs. 300 cm) did not significantly impact hemoglobin, iron, TIBC, ferritin levels, or anemia incidence among patients undergoing SASI bypass. The decrease in postoperative ferritin levels signifies a depletion in tissue iron reserves, thereby emphasizing the necessity for surveillance of iron homeostasis parameters following SASI bypass.
Assessment of undrained cyclic resistance of sand with non-plastic fines under sustained shear stress using a critical state interpretation
Authors: Tomasello Giuseppe , Porcino Daniela Dominica 
Published: June 2024

AbstractThere are many geotechnical applications involving dams, embankments and slopes where the presence of an initial static shear stress prior to the cyclic loadings plays an important role. The current paper presents the experimental results gathered from undrained cyclic simple shear tests carried out on non-plastic silty sand with fines content in the range 0-30% with the consideration of sustained static shear stress ratio (α). Two distinct parameters, namely the conventional state parameter Ψ, and the equivalent state parameter Ψ*, are introduced in the context of critical state soil mechanics (CSSM) framework to predict failure mode and undrained cyclic resistance (CRR) of investigated soils. It is proved that the failure patterns for silty sands are related to (a) the initial states of soils (Ψ or Ψ*) and (b) the combination of initial shear stress with respect to cyclic loading amplitude. At each α, the CRR-Ψ (or Ψ*) correlation can be well represented by an exponential trend which is practically unique for both clean sands and silty sands up to a threshold fines content (fthre≅24.5%). Varying α from low to high levels simply brings about a clockwise rotation of the CRR-Ψ (or Ψ*) curves around a point. This CRR-Ψ (or Ψ*) platform thus provides an effective methodology for investigating the impact of initial shear stress on the cyclic strength of both clean sands and silty sands. The methodology for estimating Ψ (or Ψ*) state parameters from in-situ cone penetration tests in silty sands is also discussed.
The association between COVID-19 vaccine/infection and new-onset asthma in children - based on the global TriNetX database
Authors: Yang Chiao-Yu , Shih Yu-Hsiang , Lung Chia-Chi 
Published: June 2024

Abstract

Introduction
The COVID-19 pandemic has underscored the importance of its potential long-term health effects, including its link to new-onset asthma in children. Asthma significantly impacts children’s health, causing adverse outcomes and increased absenteeism. Emerging evidence suggests a potential association between COVID-19 infection and higher rates of new-onset asthma in adults, raising concerns about its impact on children’s respiratory health.

Methods
A retrospective cohort study design was employed, using electronic medical records from the TriNetX database, covering January 1, 2021, to December 31, 2022. Two cohorts of children aged 5 to 18 who underwent SARS-CoV-2 RT-PCR testing were analyzed: unvaccinated children with and without COVID-19 infection, and vaccinated children with and without infection. Propensity score matching was used to mitigate selection bias, and hazard ratio (HR) and 95% CI were calculated to assess the risk of new-onset asthma.

Results
Our study found a significantly higher incidence of new-onset asthma in COVID-19 infected children compared to uninfected children, regardless of vaccination status. In Cohort 1, 4.7% of COVID-19 infected children without vaccination developed new-onset asthma, versus 2.0% in their non-COVID-19 counterparts within a year (HR = 2.26; 95% CI = 2.158–2.367). For Cohort 2, COVID-19 infected children with vaccination showed an 8.3% incidence of new-onset asthma, higher than the 3.1% in those not infected (HR = 2.745; 95% CI = 2.521–2.99). Subgroup analyses further identified higher risks in males, children aged 5–12 years, and Black or African American children. Sensitivity analyses confirmed the reliability of these findings.

Conclusion
The study highlights a strong link between COVID-19 infection and an increased risk of new-onset asthma in children, which is even more marked in those vaccinated. This emphasizes the critical need for ongoing monitoring and customized healthcare strategies to mitigate the long-term respiratory impacts of COVID-19 in children, advocating for thorough strategies to manage and prevent asthma amidst the pandemic.