bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diet influences salinity preference of an estuarine fish, the killifishFundulus heteroclitus
Authors: Bucking Carol , Wood Chris M. , Grosell Martin 
Published: May 2012

SUMMARYUnderstanding the interplay among the external environment, physiology and adaptive behaviour is crucial for understanding how animals survive in their natural environments. The external environment can have wide ranging effects on the physiology of animals, while behaviour determines which environments are encountered. Here, we identified changes in the behavioural selection of external salinity in Fundulus heteroclitus, an estuarine teleost, as a consequence of digesting a meal. Fish that consumed high levels of dietary calcium exhibited a higher preferred salinity compared with unfed fish, an effect that was exaggerated by elevated dietary sodium chloride. The mean swimming speed (calculated as a proxy of activity level) was not affected by consuming a diet of any type. Constraining fish to water of 22 p.p.t. salinity during the digestion of a meal did not alter the amount of calcium that was absorbed across the intestine. However, when denied the capacity to increase their surrounding salinity, the compromised ability to excrete calcium to the water resulted in significantly elevated plasma calcium levels, a potentially hazardous physiological consequence. This study is the first to show that fish behaviourally exploit their surroundings to enhance their ionoregulation during digestion, and to pinpoint the novel role of dietary calcium and sodium in shaping this behaviour. We conclude that in order to resolve physiological disturbances in ion balance created by digestion, fish actively sense and select the environment they inhabit. Ultimately, this may result in transient diet-dependent alteration of the ecological niches occupied by fishes, with broad implications for both physiology and ecology.
Leaf beetle attachment on wrinkles: isotropic friction on anisotropic surfaces
Authors: Voigt Dagmar , Schweikart Alexandra , Fery Andreas , Gorb Stanislav 
Published: May 2012

SUMMARYThe influence of surface roughness on the attachment ability of insects has been repeatedly reported. In previous experiments, complex surface topographies were used as test substrates, whereas periodical structures have so far been neglected. In the present study, traction experiments with adult beetles Gastrophysa viridula and Leptinotarsa decemlineata were carried out to study the influence of surfaces, structured with periodical wrinkles, on insect attachment. Force measurements were carried out on male and female insects, both intact and after removal of claws, performing tethered walking on five polydimethylsiloxane substrates: (i) smooth, non-structured (control), (ii–v) structured with wrinkles of different wavelengths (366, 502, 911 and 25,076 nm). In two test series, beetles walked either perpendicular or parallel to the wrinkle alignment. Adults of G. viridula produced generally higher forces than those of L. decemlineata. The results show that the alignment of wrinkles had no significant influence on the force generation by beetles, probably because of the skewed position of their tarsomeres relative to the substrates. In both sexes, the highest force values were obtained on surfaces with wrinkles of 25 μm wavelength. On other wrinkled substrates, forces were significantly reduced in both males and females compared with the smooth, flat control, with the minimum force achieved on wrinkles with a wavelength of 911 nm.
Is reproduction costly? No increase of oxidative damage in breeding bank voles
Authors: Ołdakowski Łukasz , Piotrowska Żaneta , Chrząścik Katarzyna M. , Sadowska Edyta T. , Koteja Paweł , Taylor Jan R. E. 
Published: May 2012

SUMMARY
According to life-history theory, investment in reproduction is associated with costs, which should appear as decreased survival to the next reproduction or lower future reproductive success. It has been suggested that oxidative stress may be the proximate mechanism of these trade-offs. Despite numerous studies of the defense against reactive oxygen species (ROS) during reproduction, very little is known about the damage caused by ROS to the tissues of wild breeding animals. We measured oxidative damage to lipids and proteins in breeding bank vole (Myodes glareolus) females after rearing one and two litters, and in non-breeding females. We used bank voles from lines selected for high maximum aerobic metabolic rates (which also had high resting metabolic rates and food intake) and non-selected control lines. The oxidative damage was determined in heart, kidneys and skeletal muscles by measuring the concentration of thiobarbituric acid-reactive substances, as markers of lipid peroxidation, and carbonyl groups in proteins, as markers of protein oxidation. Surprisingly, we found that the oxidative damage to lipids in kidneys and muscles was actually lower in breeding than in non-breeding voles, and it did not differ between animals from the selected and control lines. Thus, contrary to our predictions, females that bred suffered lower levels of oxidative stress than those that did not reproduce. Elevated production of antioxidant enzymes and the protective role of sex hormones may explain the results. The results of the present study do not support the hypothesis that oxidative damage to tissues is the proximate mechanism of reproduction costs.
Getting around when you’re round: quantitative analysis of the locomotion of the blunt-spined brittle star,Ophiocoma echinata
Authors: Astley Henry C. 
Published: May 2012

SUMMARYBrittle stars (Ophiuroidea, Echinodermata) are pentaradially symmetrical echinoderms that use five multi-jointed limbs to locomote along the seafloor. Prior qualitative descriptions have claimed coordinated movements of the limbs in a manner similar to tetrapod vertebrates, but this has not been evaluated quantitatively. It is uncertain whether the ring-shaped nervous system, which lacks an anatomically defined anterior, is capable of generating rhythmic coordinated movements of multiple limbs. This study tested whether brittle stars possess distinct locomotor modes with strong inter-limb coordination as seen in limbed animals in other phyla (e.g. tetrapods and arthropods), or instead move each limb independently according to local sensory feedback. Limb tips and the body disk were digitized for 56 cycles from 13 individuals moving across sand. Despite their pentaradial anatomy, all individuals were functionally bilateral, moving along the axis of a central limb via synchronous motions of contralateral limbs (±∼13% phase lag). Two locomotor modes were observed, distinguishable mainly by whether the central limb was directed forwards or backwards. Turning was accomplished without rotation of the body disk by defining a different limb as the center limb and shifting other limb identities correspondingly, and then continuing locomotion in the direction of the newly defined anterior. These observations support the hypothesis that, in spite of their radial body plan, brittle stars employ coordinated, bilaterally symmetrical locomotion.
Respiratory properties of blood in the harbor porpoise,Phocoena phocoena
Authors: Soegaard Lisette B. , Hansen Marie N. , van Elk Cornelis , Brahm Jesper , Jensen Frank B. 
Published: May 2012

SUMMARYHarbor porpoises are active divers that exchange O2 and CO2 with the environment during a fast single breath upon surfacing. We investigated blood O2-transporting properties, buffer characteristics, Cl– transport via the erythrocyte anion exchanger (AE1), circulating nitric oxide metabolites and hemoglobin nitrite reduction in harbor porpoises with the aim to evaluate traits that are adaptive for diving behavior. Blood O2 affinity was higher in harbor porpoises than in similar sized terrestrial mammals, as supported by our parallel recordings of O2 equilibria in sheep and pig blood. Further, O2 affinity tended to increase with increasing body mass. A high O2 affinity favors O2 extraction from the lungs, but a normal Bohr effect (ΔlogP50/ΔpH=–0.46) gradually lowers O2 affinity during dives (where CO2 accumulates) to assist O2 off-loading to perfused tissues. The true plasma non-bicarbonate buffer value was moderately higher than in terrestrial mammals and increased upon deoxygenation. Plasma bicarbonate was also relatively high, contributing to increase the overall buffer capacity. The apparent Cl– permeability of harbor porpoise erythrocytes was similar to the human value at 37°C, showing absence of a comparative increase in the velocity of erythrocyte HCO –3/Cl– exchange to aid CO2 excretion. The Q10 for AE1-mediated Cl– transport in harbor porpoises was lower than in humans and seemed to match the Q10 for metabolism (Q10≈2). Plasma nitrite, plasma nitrate and hemoglobin-mediated nitrite reduction were elevated compared with mammalian standards, suggesting that increased nitric oxide bioavailability and nitrite-derived nitric oxide could play important roles in diving physiology.
From Right Place - Wrong Person, to Right Place - Right Person: Dignified Care for Older People
Authors: Tadd Win , Hillman Alex , Calnan Michael , Calnan Sian , Read Simon , Bayer Antony 
Published: May 2012

Objectives To examine: older people's and their relatives' views of dignified care; health care practitioners' behaviours and practices in relation to dignified care; the occupational, organizational and cultural factors that impact on care; and develop evidence-based recommendations for dignified care. Methods An ethnography of four acute trusts in England and Wales involving semi-structured interviews with recently discharged older people (n = 40), their relatives (n = 25), frontline staff (n = 79) and Trust managers (n = 32), complemented by 617 hours of non-participant observation in 16 wards in NHS trusts. Results ‘Right Place - Wrong Person’ refers to the staffs' belief that acute wards are not the ‘right place’ for older people. Wards were poorly-designed, confusing and inaccessible for older people; older people were bored through lack of communal spaces and activities and they expressed concern about the close proximity of patients of the opposite sex; staff were demoralised and ill-equipped with skills and knowledge to care for older people, and organizational priorities caused patients to be frequently moved within the system. In none of the wards studied was care either totally dignified or totally undignified. Variations occurred from ward to ward, in the same ward when different staff were on-duty and at different times of the day. Conclusions The failure to provide dignified care is often a result of systemic and organizational factors rather than a failure of individual staff and it is these that must be addressed if dignified care is to be ensured.
Socioeconomic Differences in Case Finding Among General Practices in England: Analysis of Secondary Data
Authors: Dixon Anna , Khachatryan Artak , Tian Yang 
Published: May 2012

Objectives To determine how levels of case finding differ between general practices in England by level of population socioeconomic deprivation. Method Observational analysis of data from the Quality and Outcome Framework in England for 2005/06. It covered 8339 primary care practices. Reported prevalence and estimated prevalence for coronary heart disease, chronic obstructive pulmonary disease, stroke and hypertension were compared. Results The gap between estimated and reported prevalence increased with population deprivation and was higher among practices in more deprived areas (defined as Spearhead areas) for all four conditions after adjustment for practice level variables. Conclusions There is some evidence of unmet need in areas of social deprivation. Existing financial incentives in the Quality and Outcome Framework may be insufficient to promote active case finding by practices serving deprived populations.
Use of Orlistat 60 mg in the Management of Weight Loss before Bariatric Surgery
Authors: Malone Margaret , Alger-Mayer Sharon A , Lindstrom Jennifer 
Published: May 2012

BACKGROUND: Patients undergoing gastric bypass surgery are usually required to lose weight during the preoperative phase of their management. For some individuals, this is difficult to achieve with diet and exercise alone, and the use of weight loss medication may be considered a treatment option. OBJECTIVE: To evaluate the use of orlistat 60 mg taken up to 3 times daily as an adjunct to achieve the 10% preoperative weight loss recommended in this bariatric program prior to gastric bypass surgery. METHODS: The aim was to recruit 50 patients (25 treatment, 25 controls) who were in the preoperative phase of their bariatric program. Patients were referred by their physician. Control subjects were selected from individuals who were eligible but not interested in participating in the study during the same period. All patients received usual care. RESULTS: Nineteen patients (5 males) and 19 age- and sex-matched controls were included. The mean (SD) initial body mass index for the treatment versus control group was, respectively, 49.5 (10.5) versus 47.2 (4.9) kg/m2 (p = 0.559). At 3 months, the percent excess weight (EW) loss was 2.4 (3.8) (n = 15) versus 5.5 (7.6) (n = 19) (p = 0.111) and the percent total body weight (TBW) loss was 1.2 (1.9) versus 2.9 (4.1) (p = 0.103). At 6 months, the percent EW loss was 3.6 (6.4) (n = 9) versus 10.2 (8.0) (n = 16) (p = 0.036) and the percent TBW loss was 2.0 (3.4) versus 5.4 (4.2) (p = 0.048). CONCLUSIONS: Some patients felt that orlistat was beneficial for weight loss; however, overall, they did not show benefit from its addition to their preoperative weight loss management.
A Polypill for All? Critical Review of the Polypill Literature for Primary Prevention of Cardiovascular Disease and Stroke
Authors: Carey Katherine M , Cornee Morgan R , Donovan Jennifer L , Kanaan Abir O 
Published: May 2012

Objective: To evaluate the efficacy and safety of the polypill for prevention of cardiovascular disease (CVD) and stroke and to present literature related to the polypill components (statin, aspirin, antihypertensive) for primary prevention of CVD and stroke. Data Sources: A literature search was conducted in MEDLINE (1948-January 2011) and EMBASE (1974-January 2011) using the terms polypill and Polycap. When limited to clinical trials, systematic reviews, or meta-analyses, 7 studies were identified. Bibliographies of pertinent review articles and studies were scanned for additional references. A similar search was conducted to identify literature related to the use of polypill components for primary prevention of CVD and stroke. Study Selection and Data Extraction: Studies that evaluated the hypothetical benefits of a polypill and controlled trials that assessed a formulation of the polypill related to prevention of CVD and stroke were included. Studies were assessed for efficacy, safety, drug interactions, and clinical pharmacokinetics. Data Synthesis: An initial study to predict benefit estimated that a hypothetical polypill would reduce diastolic blood pressure by 11 mm Hg and low-density lipoprotein cholesterol (LDL-C) by 70 mg/dL, thus reducing the relative risks of CVD and stroke by 68% and 80%, respectively. One clinical trial in patients at low risk for CVD and stroke found that diastolic Wood pressure was reduced by 1.6 mm Hg and LDL-C was reduced by 17.7 mg/dL, correlating with 44% and 21% reduction in the relative risks of CVD and stroke, respectively. Studies in higher risk patients reported reductions in systolic blood pressure of up to 28.8 mm Hg and in LDL-C of up to 54 mg/dL, correlating with 62% and 60% relative reduction in risks of CVD and stroke, respectively. Conclusions: Polypill study results have been more modest than originally theorized. However, results show promise in patients at higher risk for CVD and stroke.
Use of Aspirin and Clopidogrel After Coronary Artery Bypass Graft Surgery
Authors: Leon Noelle de , Jackevicius Cynthia A 
Published: May 2012

Objective: To evaluate the evidence for the use of dual antiplatelet therapy (DAPT) with aspirin and Clopidogrel following coronary artery bypass graft (CABG) surgery. Data Sources: Literature was accessed through PubMed (1950-November 2011), EMBASE (1976-November 2011), and the Cochrane databases using the terms Clopidogrel and coronary artery bypass graft. Citations from available articles were used for additional references and ClinicalTrials.gov was accessed for abstracts of ongoing studies. Study Selection Ano Data Extraction: Peer-reviewed studies that evaluated DAPT use after CABQ surgery in adult humans were assessed for inclusion. Data Synthesis: Four randomized clinical trials evaluating surrogate end points and 9 studies (3 subgroup analyses, 6 observational) evaluating clinical outcomes were reviewed. Three clinical trials assessing surrogate end points failed to demonstrate an improvement in graft patency with DAPT use, while 1 clinical trial found an increase in graft patency. As for clinical outcomes, 1 subgroup analysis demonstrated that the benefit of DAPT post-CABG after a non-ST-elevation acute coronary syndrome diminished following surgery, while an observational study demonstrated a trend toward decreased mortality. In post-CABG patients who did not experience acute coronary syndrome, 2 subgroup analyses proved inconclusive and an observational study found DAPT use to be associated with reducing in-hospital mortality, while another observational study was not associated with reduced long-term mortality. Three observational studies in off-pump CABG patients showed that DAPT use was feasible. Conclusions: Evidence for DAPT use following CABG is limited to subgroup analyses, observational studies, and trials with surrogate end points. The majority of clinical trials have failed to demonstrate an improvement in graft patency with DAPT. Current evidence does not support the use of DAPT to improve graft patency, and more evidence from randomized controlled trials assessing clinical outcomes is necessary to make definitive recommendations.
Measuring The Social Opportunity Cost of Labor In Mexico
Authors: Guillermo-Peon Sylvia B. , Harberger Arnold C. 
Published: May 2012

This paper reviews the theory underlying the concept of the social opportunity cost of labor (SOCL), as that concept is used in benefit-cost analysis and in applied welfare economics generally. It then presents in detail the procedures to be followed in estimating the SOCL in real-world cases. Important steps in data processing include calculating gross and net wages from data on “reported” wages. Further economic analysis involves taking account of migration patterns and of labor market duality. Estimates are made for 32 labor market areas in Mexico, covering 21 occupations for males and 19 for females.Our main results are a) that there are important differences between reported wages and the gross wages paid by employers, and also between both of these and the net wages received by workers, and b) that taking labor market duality into account leads to significant modifications of our SOCL estimates. More important, perhaps, than our specific estimates for Mexico, is the methodological framework that we use. This framework, based on the fundamental principles of applied welfare economics, can serve as a useful starting point for serious estimation of the SOCL for other countries.
Performance Comparison of
Coherent Time-spreading and Spectral Phase
Encoding OCDMA Systems
Authors: Chen Xiaogang , Huang Dexiu 
Published: May 2012

Abstract
We compared the
bit-error-rate (BER) and throughput
performance of coherent time-spreading (TS)
and spectral phase encoding (SPE) optical code
division multiple access (OCDMA) systems. The
results indicate that for the short input
pulse (250–300 fs pulsewidth),
SPE-OCDMA can in principle yield a substantial
throughput advantage over TS-OCDMA
systems.
‘Normal people like us don’t use that type of language. Remember this is the real world.’ The language of Father Ted: representations of Irish English in a fictional world
Authors: Walshe Shane 
Published: May 2012

While Irish English speech in the TV series ‘Father Ted’ (1995–1998) will forever be associated with Father Jack’s crude catchphrases, there is much more to the representation of Irish English in the show than the use of the expletives ‘feck’ and ‘arse’. The dialect appears in a much more subtle fashion in the series and ranges from the use of the aforementioned lexical items to typically Irish grammatical and discourse features. In keeping with the author’s 2009 study on Irish English as it appears in fifty films which are set in Ireland, this paper examines the representation of the dialect in these fictional ‘texts’. It addresses whether the scriptwriters rely predominantly on grammatical, lexical or discourse features to create the impression of Irishness and it questions why particular features occur more frequently than others, thus raising the notion of saliency as a key factor in literary dialect representations of speech.
Characteristics of ocean waters reaching Greenland's glaciers
Authors: Straneo Fiammetta , Sutherland David A. , Holland David , Gladish Carl , Hamilton Gordon S. , Johnson Helen L. , Rignot Eric , Xu Yun , Koppes Michele 
Published: May 2012

AbstractInteraction of Greenland’s marine-terminating glaciers with the ocean has emerged as a key term in the ice-sheet mass balance and a plausible trigger for their recent acceleration. Our knowledge of the dynamics, however, is limited by scarcity of ocean measurements at the glacier/ocean boundary. Here data collected near six marine-terminating glaciers (79 North, Kangerdlugssuaq, Helheim and Petermann glaciers, Jakobshavn Isbræ, and the combined Sermeq Kujatdleq and Akangnardleq) are compared to investigate the water masses and the circulation at the ice/ocean boundary. Polar Water, of Arctic origin, and Atlantic Water, from the subtropical North Atlantic, are found near all the glaciers. Property analysis indicates melting by Atlantic Water (AW; found at the grounding line depth near all the glaciers) and the influence of subglacial discharge at depth in summer. AW temperatures near the glaciers range from 4.5˚C in the southeast, to 0.16˚C in northwest Greenland, consistent with the distance from the subtropical North Atlantic and cooling across the continental shelf. A review of its offshore variability suggests that AW temperature changes in the fjords will be largest in southern and smallest in northwest Greenland, consistent with the regional distribution of the recent glacier acceleration.
Dynamic instability of marine-terminating glacier basins of Academy of Sciences Ice Cap, Russian High Arctic
Authors: Moholdt Geir , Heid Torborg , Benham Toby , Dowdeswell Julian A. 
Published: May 2012

AbstractIce sheets and smaller ice caps appear to behave in dynamically similar ways; both contain slow-moving ice that is probably frozen to the bed, interspersed with fast-flowing ice streams and outlet glaciers that terminate into the ocean. Academy of Sciences Ice Cap (Akademii Nauk ice cap; 5570 km2), Severnaya Zemlya, Russian High Arctic, provides a clear example of this varied flow regime. We have combined satellite measurements of elevation change and surface velocity to show that variable ice-stream dynamics dominate the mass balance of the ice cap. Since 1988, the ice cap has lost 58±16 Gt of ice, corresponding to ~3% of its mass or 0.16mm of sea-level rise. The climatic mass balance is estimated to be close to zero, and terminus positions have remained stable to within a few kilometers, implying that almost all mass loss has occurred through iceberg calving. The ice-cap calving rate increased from ~0.6 Gt a–1 in 1995 to ~3.0 Gt a–1 in 2000–02, but has recently decreased to ~1.4 Gt a–1 due to a likely slowdown of the largest ice stream. Such highly variable calving rates have not been reported before from High Arctic ice caps, suggesting that these ice masses may be less stable than previously thought.