bluuebunny/crossref_metadata_2025_split huggingface dataset:
Colored Supramolecular Host System Using a Charge‐Transfer Complex Composed of 1,1′‐Bi‐2‐naphthol and 2,5‐Substituted 1,4‐Benzoquinone
Authors: Imai Yoshitane , Kamon Kensaku , Kinuta Takafumi , Sato Tomohiro , Tajima Nobuo , Kuroda Reiko , Matsubara Yoshio 
Published: April 2009

AbstractA colored, two‐component, supramolecular, host system has been developed. This supramolecular host system uses a charge‐transfer (CT) complex composed of racemic (rac)‐1,1′‐bi‐2‐naphthol, which acts as an electron donor, and 2,5‐substituted 1,4‐benzoquinone, which acts as an electron acceptor. This CT host system can selectively include aromatic guest molecules into a channel‐like cavity by tuning the packing of the electron‐donor and electron‐acceptor molecules. Characteristically, the color and diffuse reflectance spectra (DRS) of the inclusion CT complex can be tuned by changing the type of the component 2,5‐substituted 1,4‐benzoquinone. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Picture‐IAT versus Word‐IAT: level of stimulus representation influences on the IAT
Authors: Foroni Francesco , Bel‐Bahar Tarik 
Published: April 2009

AbstractThe Implicit Association Test is a paradigm designed to assess individual differences in implicit cognition. The goal of this report was to examine the reasons for discrepant effect magnitudes obtained with two presumably interchangeable versions: Picture‐IAT (P‐IAT) and Word‐IAT (W‐IAT). We show that this discrepancy is due to the relation between stimuli and referent category: the level of representation (LR) at which a stimulus represents an intended category. Experiment 1 replicates the discrepancies found in previous research. Experiments 2–4 show that increasing the LR of stimuli increases the IAT effect. LR affects the magnitude of the IAT effect even when modality and other features of the stimuli are kept constant. The utility of LR for future investigations examining the IAT paradigm is discussed. Copyright © 2009 John Wiley & Sons, Ltd.
Anaplastic large cell lymphoma: one or more entities among T‐cell lymphoma?
Authors: Fornari Alessandro , Piva Roberto , Chiarle Roberto , Novero Domenico , Inghirami Giorgio 
Published: April 2009

AbstractAnaplastic large cell lymphoma (ALCL) is a subtype of peripheral T‐cell lymphoma (PTCL) first described in 1985 as a lymphoid malignancy characterized by marked cellular pleomorphism, propensity to grow cohesively, tendency to invade lymph node sinuses and diffuse expression of CD30 1. The discovery of the t(2;5), involving the anaplastic lymphoma kinase (ALK) gene on chromosome 2 and the nucleophosmin (NPM) gene on chromosome 5 in the majority of systemic ALCL, has soon pointed out that ALCL is a clinically and biologically heterogeneous disease. While ALK‐positive (ALK+) ALCL is usually characterized by onset in children and young adults and better prognosis, epidemiology, poor outcome and possibly genetic defects of ALK‐negative (ALK−) ALCL suggest that this neoplasms should be considered an independent pathological entity. The aim of this review is to illustrate clinical features, histology, immunophenotype, genetics and biology of ALCL and discuss possible relationship(s) among different T‐non‐Hodgkin lymphoma (T‐NHL). Copyright © 2009 John Wiley & Sons, Ltd.
Atomic force microscopy evidence for conformational changes of fibronectin adsorbed on unmodified and sulfonated polystyrene surfaces
Authors: Kowalczyńska Hanna M. , Kołos Robert , Nowak‐Wyrzykowska Małgorzata , Dobkowski Jacek , Elbaum Danek , Szczepankiewicz Andrzej , Kamiński Jarosław 
Published: April 2009

AbstractThe effect of polystyrene surface polarity on the conformation of adsorbed fibronectin (FN) has been studied with atomic force microscopy. We demonstrated that bare sulfonated and nonsulfonated polystyrene surfaces featured similar topographies. After the FN adsorption, direct comparison of both types of substrata revealed drastically different topographies, roughness values, and also cell‐adhesive properties. This was interpreted in terms of FN conformational changes induced by the surface polarity. At high‐solute FN concentrations the multilayer FN adsorption took place resulting, for the sulfonated substratum, in an increase of surface roughness, whereas for the nonsulfonated one the roughness was approximately stable. Conversely, the FN conformation characteristic for the first saturative layer tended to be conserved in the consecutive layers, as evidenced by height histograms. The height of individual FN molecules indicated, consonantly with the derived thickness of the adsorbed protein layer (the latter value being 1.4 nm and 0.6 nm, respectively, for an unmodified and sulfonated polystyrene surface), that molecules are flattened on polar surfaces and more compact on nonsulfonated ones. It was also demonstrated that the FN adsorption and conformation on polymeric substrata, and hence the resultant cell‐adhesive properties, depended on the chemistry of the original surface rather than on its topography. Our results also demonstrated the ability of surface polarity to influence the protein conformation and its associated biological activity. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2009
Regucalcin is under‐expressed in human breast and prostate cancers: Effect of sex steroid hormones
Authors: Maia Cláudio , Santos Cecília , Schmitt Fernando , Socorro Silvia 
Published: April 2009

AbstractRegucalcin plays an important role in maintenance of intracellular Ca2+ homeostasis, suppresses cell proliferation, inhibits expression of oncogenes, and increases the expression of tumour suppressor genes. This suggests that regucalcin functions may be altered in cancer tissues. In this study the regucalcin expression in breast and prostate cancer cases was analysed by RT‐PCR and immunohistochemistry showing that the mRNA and/or protein are under‐expressed in these tumors. The effect of sex steroid hormones on regucalcin expression in breast and prostate cancer cells was determined by real‐time PCR. MCF‐7 and LNCaP cells were stimulated with 0, 1, and 10 nM of 17β‐estradiol (E2) or 5α‐dihydrotestosterone (DHT), respectively, for 0, 6, 12, 24, and 48 h. MCF‐7 cells were also stimulated with E2 conjugated to BSA (E2‐BSA). To explore the mechanisms underlying the sex steroid regulation of regucalcin expression, control treatments with ICI 182,780, flutamide and cyclohexamide were carried out. E2 effects regulating regucalcin expression were not abrogated in the presence of ICI 182,780, and were similar to those observed with E2‐BSA, which suggests the involvement of a membrane‐bound estrogen receptor. In LNCaP cells, DHT down‐regulated regucalcin expression, an effect inhibited by the presence of both flutamide and cyclohexamide, suggesting the involvement of androgen receptor and de novo protein synthesis. The loss of regucalcin expression in breast and prostate cancer cases and the regulation of its expression by sex steroid hormones suggest that it may be associated with development and progression of these human tumors. J. Cell. Biochem. 107: 667–676, 2009. © 2009 Wiley‐Liss, Inc.
The synthesis of possible hydroxylated metabolites of 2‐chlorophenothiazine derivatives
Authors: Zirnis Aija , Suzuki Joseph K. , Dickson Donald E. , Laitar Robert A. , Manian Albert A. 
Published: April 2009

AbstractThe synthesis of 7‐hydroxy, 8‐hydroxy and 7,8‐dihydroxy prochlorperazines (3a) and per‐phenazines (3b) is reported. The parent ehlorophenothiazines were prepared analogously to previously reported chlorpromazine (3e) metabolite syntheses. The prochlorperazine side chain was introduced in one step using 1‐(3‐chloropropyl)‐4‐methylpiperazine and the perphenazine side chain in two steps, first reaction with 1‐bromo‐3‐chloropropane followed by reaction with 1‐piperazineethanol. The methoxymethyleneoxy O‐proteetive groups were removed under mild conditions using methanolic hydrogen chloride. The preparations of 7‐hydroxydesmethylprochlorperazine and 7‐hydroxychlorpromazine quaternary methyl iodide are also reported.
Synthesis of ageratochromene dimer
Authors: Schwarz Meyer 
Published: April 2009

AbstractReflux of a benzene solution of 2,2‐dimethyl‐6,7‐dimethoxy‐4‐chromanol in the presence of a catalytic amount of p‐toluenesulfonic acid leads to ageratochromene dimer (II) rather than to ageratochromene (I). Treatment of I under the same conditions also produces II which is identical with the dimer of ageratochromene isolated by Kasturi and Manithomas from Ageratum conyzoides L.
Novel two step synthesis of pyrazoles and isoxazoles from aryl methyl ketones
Authors: Lin Yang‐i , Lang S. A. 
Published: April 2009

AbstractVarious acetyl aromatics when reacted with dimethylformamide dimethyl acetal gave 1‐aryl‐3‐dimethylamino‐2‐propen‐1‐ones. These intermediates are masked β‐ketoaldehydes and react with hydrazine hydrate or hydroxylamine at room temperature to give in good yields pyrazoles or isoxazoles.
Carbon‐13 and nitrogen‐15 nuclear magnetic resonance of physostigmine (eserine)
Authors: Stenberg Virgil I. , Narain Nand K. , Singh S. P. , Obenauf Ralph H. , Albright M. J. 
Published: April 2009

AbstractThe 15N and 13C nmr spectra of physostigmine are discussed along with complete assignment of the signals. This alkaloid 15 N nmr spectrum is notable because it contains nitrogens in three different environments.
as‐Triazino[4,5‐a]indoles. II. Etude des as‐triazinoindolones
Authors: Robba M. , Maume D. , Lancelot J. C. 
Published: April 2009

AbstractLasynthèsede dihydro‐1,2 oxo‐1 as‐triazino[4,5‐a]indoles est effectuée soit par réarrangement en milieu alcalin d'oxadiazolyl‐2 indoles, soit par cyclisation de N‐ethoxyméthylidènehydrazides indoliques. Le dihydro‐3,4 oxo‐4 as‐triazino[4,5‐a]indole est accessible par cyclisation de la N‐carbéthoxyhydrazone du formyl‐2 indole. La tautomérie lactime‐lactame est étudiée à l'aide des spectres ir et de rmn.
Synthesis of 2‐methyl‐3‐(3,5‐diallyl‐4‐hydroxyphenyl)‐4‐quinazolones as possible anticonvulsants
Authors: Rastogi V. K. , Parmar S. S. , Singh S. P. , Akers T. K. 
Published: April 2009

AbstractA series of 2‐methyl‐3‐(3,5‐diallyl‐4‐hydroxyphenyl)‐4‐quinazolones were prepared as possible anticonvulsants. All compounds were evaluated for their anticonvulsant activity against pentylene‐tetrazol‐induced seizures and their ability to potentiate sodium pentobarbital sleeping time in albino mice.
Investigations into the cine‐Amination of 4‐Substituted‐5‐bromopyrimidines by potassium amide in liquid ammonia
Authors: Rasmussen C. A. H. , Van Der Plas H. C. , Grotenhuis P. , Koudijs A. 
Published: April 2009

AbstractThe cine‐amination of some 4‐R‐5‐bromopyrimidines (t‐butyl, phenyl, methoxyl, piperidine, methyl, methylamino, anilino, amino) by potassium amide in liquid ammonia has been studied. Evidence is presented that the conversion into the corresponding 4‐substituted‐6‐aminopyrimidines can proceed in part via an SN(ANRORC) mechanism, involving an open‐chain intermediate, provided that the substituent at C‐4 does not contain an acidic proton in the α‐position to the pyrimidine ring. 5‐Bromo‐4‐piperidinopyrimidine yields the tele‐amination product, 2‐amino‐4‐piperidinopyrimidine, alongside the 6‐amino derivative. It is proven that the tele‐amination does not proceed via an SN(ANRORC) mechanism.
Additions radicalaires. 16 Additions d'hétérocycles oxygénés aux allènes
Authors: Montaudon E. , Thepénier J. , Lalande R. 
Published: April 2009

AbstractL'addition radicalaire du tétrahydrofuranne et du tétrahydropyranne à divers carbures alléniques conduit en particulier à des monoadduits. Une substitution croissante sur le système allénique entraǐne un enrichissement relatif en adduit issu de l'attaque centrale (pouvant alter de moins de 1% avec le propadiène á plus de 99% avec le diméthyl‐2,4 pentadiène‐2,3) et une diminution de la quantité de monoadduits isolés consécutive à une augmentation de la quantité de résidue formés.
Preparation and characterization of a new meso‐substituted tetrapyrrole macrocyclc: Meso‐tetra[2‐(3‐carboxyethyl)furyl]porphine, [TFP]
Authors: Momenteau Michel , Loock Bernard , Bisagni Emile 
Published: April 2009

AbstractThe preparation of meso‐substituted tetrafuryl‐porphines is described. These new compounds are very soluble either in organic solvent or in water depending upon the furyl groups substitution. Their spectroscopic absorption, nmr characteristics, and some of their electrochemical properties are reported.
Folic acid analogs. III.N‐(2‐[2‐(2,4‐diarnino‐6‐quinazolinyl)ethyl]benzoyl)‐l‐glutamic acid
Authors: Yan S. J. , Weinstock Louis T. , Cheng C. C. 
Published: April 2009

AbstractA trideaza analog of aminopterin,N‐(4[2‐(2,4‐diamino‐6‐quinazolinyl)ethyl]benzoyl)‐L‐glutamic acid, was prepared by a Wittig condensation of 2,4‐diaminoquinazoline‐6‐carboxaldehyde and [P‐(N‐[1,3‐bis(ethoxycarbonyl)propan‐1‐yl]aminocarbonyl)phenylmethyl]triphenylphosphonium bromide followed by catalytic reduction and mild hydrolysis. This compound was found to have confirmed inhibitory activity against leukemia L1210 in mice.
Totally synthetic steroid heterocycles. Part 7.. A facile approach to 16‐oxa‐D‐homoestrogens
Authors: Terasawa Tadao , Okada Toshihiko 
Published: April 2009

AbstractIn search of biologically active modified steroids, novel 16‐oxa‐D‐homoestrone and ‐D‐homoestradiol 3‐methyl ethers were synthesized from 16‐oxa‐3‐methoxy‐D‐homoestra‐1,3,5(10),8,14‐pentaen‐17a‐one. The straightforward synthesis involved stereoselective two‐step reduction of the 8,14‐diene system. The B/C stereoisomers were also derived from the estrapentaene. The stereostructures of these heterocyclic estrogens were determined on the basis of their spectral data.
The synthesis of heterocyclic derivatives of dibenzo[a,d]cycloheptene
Authors: Hollins Richard A. , Martins Paulo R. C. 
Published: April 2009

AbstractThe synthesis of 2‐amino‐7,8‐dihydrobenzo[1,2]cyclohepta[3,4,5‐de]quinazoline (10) and 6,7‐dihydrobenzo[1,2]cyclohepta[3,4,5‐cd]indazole (5) is described.
Synthesis and thermolysis of N‐heteroarylacetylazides and α‐oximino‐α‐(N‐heteroaryl)acetylazides
Authors: Iwao Masatomo , Kuraishi Tsukasa 
Published: April 2009

AbstractTreatment of N‐heteroarylacethydrazides with an equimolar amount of nitrous acid afforded N‐heteroaryacetylazides and subsequent thermolysis of these azides gave the analogues of 2,3‐dihydroimidazo[1,5‐a]pyridin‐3‐one. When some of these cyclized compounds were treated with nitrous acid, the ring opening reaction occurred and recyclized 3‐(N‐heteroaryl)‐1,2,4‐oxadiazolin‐5‐ones were obtained. Treatment of N‐heteroarylacethydrazides with two equivalent moles of nitrous acid afforded α‐oximino‐α‐(N‐heteroaryl)acetylazides. Thermolysis of these azides gave mixtures of 3‐(N‐heteroaryl)‐1,2,4‐oxadiazolin‐5‐one and 3‐hydroxy‐4‐(N‐heteroaryl)furazan. On the basis of the effects of heterocyclic rings and solvents upon the relative yield of two types of the products, one plausible mechanistic explanation for the decomposition of such azides was proposed. α‐Oximino‐α‐(H‐heteroaryl)acetylazides were converted into cyano N‐heterocycles by the action of alkali in good yields.
Synthèse de dérivés de la benzo[c] quinolizine
Authors: Vierfond Jean‐Michel , Mettey Yvette , Joubin Raymond , Miocque Marcel 
Published: April 2009

AbstractPour introduire des centres polaires dans des systèmes pluricycliques plans en vue d'étudier leur action intercalante, on a préparé des dérivés de benzo[c]quinolizinium fonctionnalisés par un groupement OH ou NH2: les précurseurs cétoniques ou iminés sont obtenus à partir du picolyl‐2 ou du quinaldyllithium; ils subissent ensuite une cyclisation par quaternisation mettant vraisemblablement en jeu un processus concerté. La structure des composés obtenus et de certains de leurs dérivés est étudiée.
Fused indoles. 2. Synthesis and reactions of imidazo[1,2‐a]‐ and pyrimido[1,2‐a]‐indoles
Authors: Coppola Gary M. , Hardtmann Goetz E. 
Published: April 2009

AbstractThe alkylation of 2‐chloroindole‐3‐carboxaldehyde (1) and 3‐acetyl‐2‐chloroindole (5) with 3‐chloro‐N,N‐dimethyl‐1‐propylamine, 3‐chloro‐N,N‐diethyl‐1‐propylamine and 2‐chloro‐N,N‐dimethyl‐1‐ethylamine is described. Following alkylation, demethylation occurs and furnishes imidazo[1,2,‐a]‐ and pyrimido[1,2‐a]indoles (3a,6,8,10). Pyrimido‐indole 3a, on treatment with lithium aluminum hydride, furnishes the bis‐indole 12. Analogous reaction with diborane affords the reduced product 14, while reaction with methyllithium yields the deformylated product 13. Spectral data of the resulting compounds are also discussed.
Recherches en série diazépine‐1,4 et triazépine‐1,2,4. XV. Syntlièse d'halogéno‐3(7)‐s‐triazolo[4,3‐b] triazépinones
Authors: Essassi E. M. , Lavergne J.‐P. , Viallefont Ph. 
Published: April 2009

AbstractL'halugénution de s‐triazolo[4,3‐b] triazépinones selon différentes méthodes a été réalisée. Selon les conditions expérimentales et les agents d'halogénation il a été possible d'halogéner le cycle triazépine (position 7) ou (et) le cycle triazole (position 3). Au total 18 halogéno s‐triazolo triazépinones ont ainsi été préparées et les structures établies a partir de l'ensemble des données spectrales.
Total synthesis of a B‐ring “homoalkaloid”. 4,5,6,7,7a,8‐Hexahydro‐7‐methylphenanthro[10,1‐bc]azepine
Authors: Jensen Bruce L. , Woods Michael A. 
Published: April 2009

AbstractThe synthesis of a novel benzazepine, 4,5,6,7,7a,8‐hexahydro‐7‐methylphenanthro[10,1‐bc]‐azepine, is described. Two pathways leading from 1,2,4,5‐tetrahydro‐1‐(o‐nitrophenyl)‐3H‐2‐benzazepin‐3‐one were investigated. The most successful route, utilizing a Pschorr cyclization followed by diborane reduction and Eschweiler‐Clarke methylation, led to an excellent yield of the title compound.
Substituted 2,3,4,5‐tetrahydro‐1H‐3‐benzazepine and 2,3,4,5‐tetrahydro‐1H‐naphth[1,2‐d] azepine derivatives
Authors: Bobowski George , Gottlieb Jeffrey M. , West Barbara , Shavel John 
Published: April 2009

AbstractThe multi‐step synthetic procedures to prepare a number of 2,3,4,5‐tetrahydro‐1H‐benzazepine derivatives 1 through a series of intermediates are described. The condensation of arylaldehydes2with 2‐nitropropanes3gave nitroalcohols4which were reduced to alcohol amines5. The condensation of5with arylacetaldehydes6gave imino derivatives7which on reduction with borohydride gave secondary amines8. By employing different methods, alcohol amines5were condensed with arylacetic acids9to give amides10which were then reduced to amines8. On treatment with mineral acids, amines8were cyclized to the target compounds1. Biological activities of1are also briefly discussed.
Pyridinethiones. IX preparation of ricinidine, thioricinidine and other 2(1H)‐pyridones and ‐thiones related to nicotinic acid
Authors: Becher Jan , Johansen Tea , Michael Maged Aziz 
Published: April 2009

Abstract2(1H)‐Pyridones and ‐thiones related to 1‐substituted nicotinic acid derivatives have been prepared via the corresponding l‐substituted‐3‐formyl‐2(1H)‐pyridones and ‐thiones. A number of synthetic procedures for the interconversion of functional groups in these nicotinic acid derivatives are given i.e. preparation of the aldoximes, nitriles, carboxamides and carboxylic acids as well as the 3‐ hydroxyalkyl derivatives. The course of the basic peroxide oxidation of the l‐substituted‐3‐formyl‐2(1H)‐pyridinethiones is found to be very dependent upon the electronegativity of the 1‐substituent. A preparation of ricinidine is also described.
An investigation of some base induced transformations of the 1,4‐benzodioxan ring system
Authors: Chapleo Christopher B. , Davis John A. , Myers Peter L. , Readhead Michael J. , Stillings Michael R. , Welbourn Anthony P. , Hampson Frank C. , Sugden Keith 
Published: April 2009

AbstractThe reaction between benzodioxan‐2‐carboxylic acid and ethylenediamine has been examined and related base induced transformations investigated.
The preparation and the nucleophilic reaction of 3,3‐di(1‐azolyl)‐2‐alken‐1‐ones, precursor of acetylketene derivatives
Authors: Kashima Choji , Tajima Tadakuni , Omote And Yoshimori 
Published: April 2009

Abstract2‐Alken‐1‐ones, 3,3‐di‐(1‐azolyl)‐2‐alken‐1‐ones and related compounds were prepared by two methods. These compounds were found to be the useful precursors for acylketene derivatives such as ketene dithioacetals and diaminals by treatment with various nucleophiles.
The assignment of the 1H‐NMR and 13C‐NMR spectra of 5H‐dibenz[b,f]azepine and 10,11‐dihydro‐5H‐dibenz[b,f]azepine
Authors: Hallberg A. , Al‐Showaier I. , Martin A. R. 
Published: April 2009

AbstractThe total assignments of the 1H‐nmr and 13C‐nmr spectra of 5H‐dibenz[b,f]azepine [1] and 10,11‐dihydro‐5H‐dibenz[b,f]azepine (2) have been made based on comparison with the corresponding 4,6‐dideuterated derivatives 3, and 4. These compounds were prepared via repeated lithiations and subsequent deuterations of 1 and 2.
Synthesis of some 4H,10H[1]benzoxepino[3,4‐c]pyrazol‐4‐one derivatives
Authors: Deshayes Christian , Chabannet Michel , Gelin Suzanne 
Published: April 2009

Abstract1H(or 2H)4H10H[1]Benzoxepino[3,4‐c]pyrazol‐4‐ones were prepared from phenoxymethylpyrazolecarboxylic acids which in turn were synthesized from simple starting materials. Different pathways to allow the predominant formation of the N‐1 or N‐2 substituted derivatives are described. The isomeric 1 or 2‐substituted structures were supported by 13C‐nmr.
C(6)N(7)‐cyclized purines
Authors: Griengl H. , Hayden W. , Plessing A. 
Published: April 2009

AbstractBy reaction of 6‐[N‐(2‐hydroxyethyl)‐N‐methyl]aminopurine (2a) and of the corresponding 3‐hydroxypropyl derivative 2b with thionyl chloride a bridge to N(1) is formed yielding 5 and 6, respectively, whereas from 6‐[N‐(4‐hydroxybutyl)‐N‐methyl]aminopurine (2c) the 4‐chlorobutyl compound 4 is obtained, which cyclizes in alkaline medium to the C(6)‐N(7) bridged compound 7. A related cyclization to 11a–11f is observed when 6‐chloropurines are reacted with 3‐alkyl‐1,3‐oxazolidines or 3‐methyl‐1,3‐thiazolidine.
Synthesis of bis(2‐chloroethyl)amino‐1,8‐naphthyridines for evaluation as anticancer agents
Authors: Ferrarini Pier Luigi , Mori Claudio , Biagi Giuliana , Livi Oreste , Tonetti Imperio 
Published: April 2009

AbstractSome 1,8‐naphthyridine nitrogen mustards have been synthesized for studies of their antitumor potentialities. All the tested intermediate and target compounds are devoid of antitumor properties.
Synthesis of some spin‐labeled bithiazoles, Useful probes for studying bleomycin‐DNA binding
Authors: Houssin Raymond , Bernier Jean‐Luc , Hénichart Jean‐Pierre 
Published: April 2009

AbstractThe antibiotic antitumor drug Bleomycin is known to bind to DNA by intercalation of its bithiazole chromophore into the DNA base‐pairs. Four spin‐labeled bithiazoles, bearing a 4‐(2,2,6,6‐tetramethyl‐1‐piperidinooxy) free radical, have been synthesized. These derivatives where the nitroxide group is linked to the end of spacers of various lengths, can be used as probes for the study, by esr spectroscopy, of the intercalation of the heterocyclic moiety of Bleomycin.
Etude de quelques dérivés N‐3‐substitués et N‐1,N‐3‐disubstitués de la cyclohexanospirohydantoîne
Authors: Pedregal Carmen , Trigo Gregorio G. , Espada Modesta , Elguero José , Vincent Emile‐Jean , Faure Robert 
Published: April 2009

Abstractl'alcoylation de la cyclohexanospirohydantoîne dans des conditions classiques et en transfert de phase conduit respectivement aux derivés N‐3‐substitués et aux derivés N‐1,N‐3‐disubstitués. l'application successive de ces méthodes a permis d'accéder facilement aux hydantoînes portant deux substituants différents. Les différents produits obtenus ont été etudiés par rmn du 13C. Cette méthode permet d'identifier les produits mono‐ et disubstitués ainsi que de déterminer la position du substituant.