bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: A Novel CAN‐SiO2‐Mediated One‐Pot Oxidation of 1‐Keto‐1,2,3,4‐tetrahydrocarbazoles to Carbazoloquinones: Efficient Syntheses of Murrayaquinone A and Koeniginequinone A.
Authors: Chakraborty Suchandra , Chattopadhyay Gautam , Saha Chandan 
Published: June 2011

AbstractA series of carbazoloquinones, e.g. murrayaquinone A (IIb) and koeniginequinone A (IIh), is readily prepared by a solvent‐free oxidation of corresponding carbazolones (I) with silica‐supported CAN.
ChemInform Abstract: Efficient Synthesis of 4,4′‐(Arylmethylene)‐bis(3‐methyl‐1‐phenylpyrazol‐5‐ol) Derivatives in PEG‐400 under Catalyst‐Free Conditions
Authors: Hasaninejad Alireza , Zare Abdolkarim , Shekouhy Mohsen , Golzar Nooshin 
Published: June 2011

Abstract16 examples
ChemInform Abstract: Fast, Ligand‐ and Solvent‐Free Copper‐Catalyzed Click Reactions in a Ball Mill.
Authors: Thorwirth Rico , Stolle Achim , Ondruschka Bernd , Wild Andreas , Schubert Ulrich S. 
Published: June 2011

AbstractThe Huisgen cycloaddition proceeds highly selective under mild conditions and very short reaction times employing a planetary ball mill together with fused quartz sand as a milling auxiliary.
ChemInform Abstract: Synthesis and Evaluation of Some Novel 1,3,4‐Thiadiazoles for Antidiabetic Activity.
Authors: Pattan S. R. , Kittur B. S. , Sastry B. S. , Jadav S. G. , Thakur D. K. , Madamwar S. A. , Shinde H. V. 
Published: June 2011

AbstractThe new 1,3,4‐thiadiazoles (IIIa) and (IIIe) show significant antidiabetic activities.
ChemInform Abstract: Natural Product Biosynthesis Inspired Concise and Stereoselective Synthesis of Benzopyrones and Related Scaffolds.
Authors: Baskar Baburaj , Dakas Pierre‐Yves , Kumar Kamal 
Published: June 2011

AbstractBiologically relevant tri‐ and tetracyclic benzopyrones are prepared from 3‐formylchromones and various allenes.
ChemInform Abstract: Highly Enantioselective and Efficient Synthesis of Flavanones Including Pinostrobin Through the Rhodium‐Catalyzed Asymmetric 1,4‐Addition.
Authors: Korenaga Toshinobu , Hayashi Keigo , Akaki Yusuke , Maenishi Ryota , Sakai Takashi 
Published: June 2011

AbstractA variety of bioactive flavanones is prepared.
ChemInform Abstract: Reaction of Benzyne with Formamides and Acetylimidazole.
Authors: Okuma Kentaro , Nojima Akiko , Nakamura Yuki , Matsunaga Nahoko , Nagahora Noriyoshi , Shioji Kosei 
Published: June 2011

AbstractThe reaction of benzyne, generated in situ from o‐trimethylsilylphenyl triflate (I) with dimethylformamide or acetylimidazole (VI) provides a novel approach to the synthesis of xanthene derivatives.
ChemInform Abstract: Sonogashira Reaction on Pyridinium N‐Heteroarylaminides.
Authors: Cordoba Marta , Izquierdo M. Luisa , Alvarez‐Builla Julio 
Published: June 2011

AbstractA general protocol is developed for the Pd‐catalyzed coupling of pyridinium amidine (I) with terminal acetylenes (II) using DABCO as the base under microwave irradiation in acetonitrile or water as the solvent.
ChemInform Abstract: Regioselective Syntheses of 2,3‐Substituted Pyridines by Orthogonal Cross‐Coupling Strategies.
Authors: Koley Moumita , Wimmer Laurin , Schnuerch Michael , Mihovilovic Marko D. 
Published: June 2011

AbstractMicrowave‐assisted C—N cross‐coupling reactions of (I) followed by Suzuki—Miyaura coupling give 2‐aryl/alkylamino‐3‐arylpyridines.
ChemInform Abstract: Synthesis and in vitro Fungicidal Activity of a Series of Novel N‐(Heterocyclo)phthalimides.
Authors: Ban Shurong , Chen Wenbin , Xi Zhen 
Published: June 2011

AbstractNew N‐(heterocyclo)phthalimides (III), (V) and (VII) are synthesized from corresponding phthalic anhydride derivatives and tested for their antifungal activities.
ChemInform Abstract: Intramolecular Hydride Addition to Pyridinium Salts: New Routes to Enantiopure Dihydropyridones.
Authors: Donohoe Timothy J. , Connolly Matthew J. , Rathi Akshat H. , Walton Lesley 
Published: June 2011

AbstractHydride transfer in the pyridinium salts (II) becomes possible in the presence of Bu4NF to give diastereomers (IV) as the main products.
ChemInform Abstract: Synthesis of Novel 3‐Bromo‐1,2‐dihydroquinolines via Palladium‐Mediated Intramolecular Cyclization of N‐Tosyl‐N‐propargyl Anilines.
Authors: Gurunathan Savitha , Perumal Paramasivam Thirumalai 
Published: June 2011

AbstractA simple procedure allows the efficient preparation of the target compounds.
ChemInform Abstract: Synthesis of CF3‐Substituted 1,2,3,4‐Tetrahydroisoquinolines and 1,2,3,6‐Tetrahydropyridines.
Authors: Chernyshov I. Yu. , Levin V. V. , Dilman A. D. , Belyakov P. A. , Struchkova M. I. , Tartakovsky V. A. 
Published: June 2011

AbstractA simple and convenient procedure for the preparation of CF3‐substituted isoquinoline and pyridine derivatives is developed using nucleophilic trifluoromethylation under acidic conditions.
ChemInform Abstract: Synthesis and Antifungal Activity of Furo[2,3‐f]quinolin‐5‐ols.
Authors: Ryu Chung‐Kyu , Kim Yang Hui , Nho Ji‐Hee , Hong Jung An , Yoon Joo Hee , Kim Aram 
Published: June 2011

AbstractCyclization reactions of quinolinedione derivatives (III) and (VI) with hydrazine, alkyl‐ or arylthiols afford the corresponding furoquinolinol scaffolds in moderate to good yields.
ChemInform Abstract: Catalytic Enantioselective Synthesis of A‐86929, a Dopamine D1 Agonist.
Authors: Hajra Saumen , Bar Sukanta 
Published: June 2011

AbstractDopamine D1 agonist A‐86929 (IV) is synthesized via an one‐pot aziridination and Friedel—Crafts cyclization of compound (I) as key step.
ChemInform Abstract: Synthesis of Isoquinuclidinones via a Tandem Amination/Imination Sequence: Application to the Synthesis of (‐)‐Mearsine.
Authors: Cuthbertson James D. , Godfrey Andrew A. , Taylor Richard J. K. 
Published: June 2011

AbstractThe sequence converts 6‐acyl‐cyclohex‐2‐enones of type (I) directly to the required isoquinuclidinones.
ChemInform Abstract: Synthesis of 2‐(2‐Hydroxybenzyl)phthalazin‐1(2H)‐ones.
Authors: Osyanin V. a. , Ivleva E. A. , Klimochkin Yu. N. 
Published: June 2011

AbstractReaction of phthalazinone (I) with o‐methylenequinones generated from salicyl alcohols (II) affords the products of a Michael 1,4‐addition (III) instead of phthalazinobenzoxazines.
ChemInform Abstract: Synthesis and in vitro Cytotoxicity Evaluation of Some Fluorinated Hexahydropyrimidine Derivatives.
Authors: Agbaje Oluropo C. , Fadeyi Olugbeminiyi O. , Fadeyi S. Adamson , Myles Lewis E. , Okoro Cosmas O. 
Published: June 2011

AbstractThe one‐pot condensation of trifluoroacetoacetates (I), aromatic aldehydes (II), and thiourea (III) gives rise to the formation of hexahydropyrimidines (IV) in moderate to very good yields.
ChemInform Abstract: Substrate‐Controlled Chemoselective Synthesis and Potent Cytotoxic Activity of Novel 5,6,7‐Triarylpyrido[2,3‐d]pyrimidin‐4‐one Derivatives.
Authors: Shi Feng , Ding Jie , Zhang Shu , Hao Wen‐Juan , Cheng Chuang , Tu Shujiang 
Published: June 2011

AbstractSterically hindered triarylpyridopyrimidinone derivatives (IV) or (VI) are obtained by controlling the educts in microwave‐assisted three‐component reactions.
ChemInform Abstract: A Concise and Cascade Synthesis of Batracylin and Substituted Isoindolo[1,2‐b]quinazolin‐12(10H)‐ones.
Authors: Shankar R. , Wagh Manoj Balu , Madhubabu M. V. , Vembu N. , Kumar U. K. Syam 
Published: June 2011

AbstractThe synthesis of the title skeleton is readily achieved through a cascade cyclization of 2‐cyanomethyl benzoate with aminobenzyl alcohols.
ChemInform Abstract: Pd(II)‐Catalyzed ortho‐Arylation of 6‐Arylpurines with Aryl Iodides via Purine‐Directed C—H Activation: A New Strategy for Modification of 6‐Arylpurine Derivatives.
Authors: Guo Hai‐Ming , Jiang Li‐Li , Niu Hong‐Ying , Rao Wei‐Hao , Liang Lei , Mao Run‐Ze , Li De‐Yang , Qu Gui‐Rong 
Published: June 2011

AbstractThe reaction proceeds selectively as a monoarylation in ortho position even with an excess of aryl iodides.
ChemInform Abstract: Copper‐Catalyzed C—P Bond Construction via Direct Coupling of Phenylboronic Acids with H‐Phosphonate Diesters.
Authors: Zhuang Rongqiang , Xu Jian , Cai Zhenshi , Tang Guo , Fang Meijuan , Zhao Yufen 
Published: June 2011

AbstractThe use of aerobic conditions is crucial as a reaction carried out under inert or oxygen atmosphere leads to poor results.
ChemInform Abstract: “On‐Water” Michael‐Type Addition Reactions Promoted by PhSeZnCl.
Authors: Battistelli Benedetta , Lorenzo Testaferri , Tiecco Marcello , Santi Claudio 
Published: June 2011

AbstractThe Michael‐type addition of (II) to alkenes and alkynes in water presents an effective and eco‐friendly alternative to existing methods.
ChemInform Abstract: Identification and Evaluation of Soft Coral Diterpenes as Inhibitors of HIF‐2α Induced Gene Expression.
Authors: Grkovic Tanja , Whitson Emily L. , Rabe Daniel C. , Gardella Roberta S. , Bottaro Donald P. , Linehan W. Marston , McMahon James B. , Gustafson Kirk R. , McKee Tawnya C. 
Published: June 2011

AbstractThe extraction of three active marine soft corals of the order Alcyonacea (Sarcophyton sp., L.
ChemInform Abstract: Efficient Synthesis of Triazole Moiety‐Containing Nucleotide Analogues and Their Inhibitory Effects on a Malic Enzyme.
Authors: Hou Shuhua , Liu Wujun , Ji Debin , Zhao Zongbao 
Published: June 2011

AbstractThe synthesis of the title compounds (V) involves lipase‐mediated selective deacylation of β‐D‐ribofuranoside (II) and the Huisgen 1,3‐dipolar cycloaddition between terminal alkynes and an 1‐azido ribofuranoside derivative as key steps.
ChemInform Abstract: Synthesis and Cytotoxicity of Bis‐1,3,4‐oxadiazoles and Bispyrazoles Derived from 1,4‐Bis[5‐thio‐4‐substituted‐1,2,4‐triazol‐3‐yl]‐butane and Their DNA Binding Studies.
Authors: Purohit Madhusudan , Prasad V. V. S. Rajendra , Mayur Yergeri C. 
Published: June 2011

AbstractThe new compounds (I) are screened for their in vitro cytotoxicity against the cancer cell lines lung carcinoma A‐549, colon carcinoma HT‐29, and breast cancer MDA MB‐231.
Practical Determination of the Heat Transfer Coefficients at Bodies with Arbitrary Geometry
Authors: Moschallski Andreas , Rückert Jan Philipp , Herwig Heinz 
Published: June 2011

AbstractEs wird ein Verfahren zur einfachen experimentellen Bestimmung des mittleren Wärmeübergangskoeffizienten an geometrisch unterschiedlichen Bauteilen in einer stationären Strömung vorgestellt. Das Verfahren beruht auf der Messung des zeitabhängigen Temperaturverlaufes des Bauteils und der Bestimmung des Wärmeübergangskoeffizienten auf Basis der Energieerhaltungsgleichung. Anhand der Körpergeometrie einer Kugel wird die konkrete Anwendung dargestellt und anschließend gezeigt, dass die so ermittelten Wärmeübergangsdaten gut mit denjenigen aus der Literatur übereinstimmen.
Two step biodiesel production from Calophyllum inophyllum oil: Studies on thermodynamic and kinetic modelling of modified β‐zeolite catalysed pre‐treatment
Authors: Sathyaselvabala Vasanthakumar , Ponnusamy Senthilkumar , Periyaraman Premkumar Manickam , Selvaraj Dinesh Kirupha , Thangaraj Vidhyadevi , Subramanian Sivanesan 
Published: June 2011

AbstractBiodiesel is one of the alternative fuels that can help in reducing oil dependence. β‐Zeolite was modified with phosphoric acid and the modified β‐zeolite was used as catalyst for the esterification of free fatty acids (FFA) present in pinnai oil and its effect on esterification reaction was studied. Influence of catalyst amount, methanol to oil ratio and temperature on specific reaction rate was modelled using Langmuir–Hinshelwood (LH) kinetics, pseudo first order kinetics and Arrhenius equation, respectively. The kinetic constant values obtained in LH kinetics show that the adsorption capacity of FFA on catalyst surface was approximately 23 times higher than that of methanol. From pseudo first order kinetic modelling it is found that methanol to oil molar ratio of 9 gives the optimum k value. Thermodynamic studies were also performed to prove the endothermic nature of Pβ catalysed esterification reaction. © 2011 Canadian Society for Chemical Engineering
Aspekte von Bewertungskompetenz im naturwissenschaftlichen Unterricht
Authors: Heitmann Patricia , Tiemann Rüdiger 
Published: June 2011

AbstractDie Fähigkeit zu Bewerten ist einer von vier Kompetenzbereichen der nationalen Bildungsstandards. Sie umfasst die Kompetenz von Lernenden, zu naturwissenschaftlichen Problemstellungen, die auch eine gesellschaftliche Relevanz haben, eine Position beziehen zu können. Als eine Heranführungsweise an Bewertungsthemen wird in diesem Artikel die Einbindung in einen Problemlösekontext aufgezeigt, in dem Lernende fachspezifisches Wissen und Erkenntnisse erarbeiten. Von Interesse ist dabei, inwieweit Schülerinnen und Schüler der zehnten Jahrgangsstufe naturwissenschaftliche Bewertungskriterien für ihre Urteile einsetzen. Neben der Darstellung der theoretischen Grundlagen zu diesem Kompetenzbereich werden daher auch Schülerurteile aus Testaufgaben zur Diagnose der Bewertungskompetenz diesbezüglich analysiert.
Chemische Begriffe im biologischen Kontext
Authors: Geyer Ina , Heimann Rebekka 
Published: June 2011

AbstractIn diesem Artikel beschreiben wir ein Experimentalkonzept zum Einstieg in das Thema Säuren, in dem erste Eigenschaften von Säuren über das Lösen von biologisch eingebetteten Fragestellungen erarbeitet werden. Das Konzept wurde mit Achtklässlern erprobt. Die Erfahrungen bezüglich des Lernzuwachses und der Schülereinstellungen werden dargestellt.
Clopidogrel With Proton Pump Inhibitors: Safe or Not?
Authors: Mehta Anuj , Mehta Deeksha , Loganathan Jayanthi , Paladugu Neelima , Bhalodkar Narendra C. 
Published: June 2011

AbstractGastrointestinal (GI) bleeding is a serious complication associated with use of antiplatelet therapy, and proton pump inhibitors (PPIs) are known to be beneficial in decreasing such risk. Several studies in the recent past have suggested concerns regarding interaction between clopidogrel and PPIs, presumably due to inhibition of clopidogrel activity and thus attenuation of its antiplatelet activity. A web‐based literature and guidelines search was done using the keywords “clopidogrel,” “omeprazole,” “proton pump inhibitors” and “interaction.” Of the available results, relevant studies (n = 11) were then systematically reviewed and summarized. The studies were categorized based on their retrospective or prospective nature. Most of the retrospective, observational studies suggested a link between the 2; however, recent prospective studies have shown no interaction, as well as a positive influence of PPIs in preventing the GI side effects of antiplatelet therapy. There is currently insufficient clinical evidence to suggest interaction between clopidogrel and PPIs and decision to add PPI therapy to clopidogrel should be guided by its clinical indications rather than as a routine prophylactic measure. © 2011 Wiley Periodicals, Inc.
Assessment of Heavy Metal Contamination of Wetland Soils from a Typical Aquatic–Terrestrial Ecotone in Haihe River Basin, North China
Authors: Xiao Rong , Bai Junhong , Wang Qinggai , Gao Haifeng , Huang Laibin , Liu Xinhui 
Published: June 2011

AbstractSurface soils were collected in the aquatic–terrestrial ecotone (ATE) of Yongnianwa wetland, downstream of Haihe River basin of North China in June of 2007. Samples were subjected to a total digestion technique before they were analyzed for total concentrations of Cr, Cu, Ni, Pb, and Zn to investigate their pollution levels in the ATE. The contamination index, integrated contamination index, geoaccumulation index, toxic units, and sum of toxic units were adopted to assess the heavy metal contamination levels and ecotoxicity, respectively. The results showed all the selected element concentrations in upland soils of the ecotone were relatively higher than those in the lowland soils. No Cr pollution was observed in all soil samples, but almost all samples were slightly polluted by Cu, Ni, Pb, and Zn except for Site 1. The contamination indexes and geoaccumulation indexes consistently presented no contamination for Site 1 and slight contamination for other sites. The ΣTUs increased from lowland to upland, but the whole level of toxicity in this ecotone was relatively low.
Impact of evidence‐based clinical guidelines on the adoption of postmastectomy radiation in older women
Authors: Shirvani Shervin M. , Pan I‐Wen , Buchholz Thomas A. , Shih Ya‐Chen Tina , Hoffman Karen E. , Giordano Sharon H. , Smith Benjamin D. 
Published: June 2011

AbstractBACKGROUND:Although postmastectomy radiation therapy (PMRT) improves survival for patients with high‐risk breast cancer, previous literature suggested that it is underused. The impact of recent clinical guidelines on PMRT use is unknown. Accordingly, the authors used the Surveillance, Epidemiology, and End Results (SEER)‐Medicare cohort to determine whether the use of PMRT has increased in response to evidence‐based guidelines.METHODS:In total, 38,322 women aged ≥66 years who underwent mastectomy for invasive breast cancer between 1992 and 2005 were identified. Time trends in the receipt of PMRT for low‐risk (T1/T2 N0), intermediate‐risk (T1/T2 N1), and high‐risk (T3/T4 and/or N2/N3) patients were characterized. Multivariate logistic regression identified risk factors for PMRT omission.RESULTS:The receipt of PMRT by patients with high‐risk breast cancer increased from 36.5% (95% confidence interval, 26%‐46.9%) to 57.7% (95% confidence interval, 46.9%‐68.4%) between 1996 and 1998 with the publication of landmark clinical trials. However no further increase in PMRT use was observed between 1999 and 2005 despite publication of multiple guidelines endorsing its use; during this period, only 54.8% (2729 of 4978) of high‐risk patients received PMRT. Within this high‐risk group, patients with smaller tumors or less advanced lymph node disease were at risk for PMRT omission.CONCLUSIONS:After an initial increase in PMRT use in response to clinical trials, the use of PMRT did not increase further in response to guideline publication, and nearly 50% of patients with high‐risk breast cancer still do not receive PMRT. Additional research is needed to determine how clinical guidelines can be used to bridge the gap between level I evidence and clinical practice. Cancer 2011;. © 2011 American Cancer Society
Polycomb group protein EZH2 is frequently expressed in inflammatory breast cancer and is predictive of worse clinical outcome
Authors: Gong Yun , Huo Lei , Liu Ping , Sneige Nour , Sun Xiaoping , Ueno Naoto T. , Lucci Anthony , Buchholz Thomas A. , Valero Vicente , Cristofanilli Massimo 
Published: June 2011

AbstractBACKGROUND:Enhancer of zeste homolog 2 (EZH2), a member of polycomb group proteins, is involved in the regulation of cell cycle progression and has been implicated in various human malignancies, including breast cancer, and also has been associated with aggressive tumor behavior. However, the clinical significance of EZH2 expression in inflammatory breast cancer (IBC), a rare but aggressive type of breast carcinoma, has not been explored. In this retrospective study, the authors examined EZH2 expression in IBC tumors and evaluated the relation between EZH2 expression and patient survival.METHODS:Tissue microarrays of 88 surgically resected IBC tumors were stained immunohistochemically for EZH2, and the authors evaluated the association of EZH2 expression status with clinicopathologic factors and clinical outcome.RESULTS:The median follow‐up for the entire cohort was 45.7 months, and the 5‐year overall survival (OS) rate was 45%. EZH2 was expressed frequently in IBC tumors (75.7%) and was associated significantly with unfavorable prognostic factors, such as higher tumor grade, negative estrogen receptor status, and triple‐negative status (ie, negative for the estrogen, progesterone, and human epidermal growth factor 2 receptors). Univariate survival analysis indicated that patients who had EZH2‐positive IBC had a significantly lower 5‐year OS rate than patients who had EZH2‐negative IBC (P = .01). In multivariate analysis, only positive EZH2 status remained an independent predictor of worse OS.CONCLUSIONS:EZH2 was expressed frequently in IBC tumors. The current results indicated that EZH2 expression status may be used to identify a subset of patients with IBC who have a relatively worse prognosis. Targeting EZH2 also may provide a novel strategy for improving the clinical outcome of patients with IBC. Cancer 2011;. © 2011 American Cancer Society.
Human immunodeficiency virus‐associated lung cancer in the era of highly active antiretroviral therapy
Authors: Pakkala Suchita , Chen Zhengjia , Rimland David , Owonikoko Taofeek K. , Gunthel Clifford , Brandes Johann R. , Saba Nabil R. , Shin Dong M. , Curran Walter J. , Khuri Fadlo R. , Ramalingam Suresh S. 
Published: June 2011

AbstractBACKGROUND:Lung cancer is the leading cause of death among non‐acquired immunodeficiency syndrome (AIDS)‐defining malignancies. Because highly active antiretroviral therapy (HAART) has improved the survival of patients with human immunodeficiency virus (HIV), the authors evaluated lung cancer outcomes in the HAART era.METHODS:HIV‐positive patients who were diagnosed with lung cancer at the authors' institution during the HAART era (1995‐2008) were analyzed. Patient charts were reviewed for clinical and laboratory data. The CD4 count at diagnosis was treated as a continuous variable and subcategorized into distinct variables with 3 cutoff points (50 cells/mL, 200 cells/mL, and 500 cells/mL). Pearson correlation coefficients were estimated for each covariate studied. Survival was determined by using the Kaplan‐Meier method.RESULTS:Of 80 patients, 73 had nonsmall cell lung cancer. Baseline characteristics were as follows: median patient age, 52 years; male, 80%; African Americans, 84%; injection drug users, 25%; smokers, 100%; and previous exposure to antiretroviral agents, 55%. At the time of cancer diagnosis, the mean CD4 count was 304 cells/mL, and the mean viral load was 82,420 copies/mL. The latency between HIV diagnosis and lung cancer diagnosis was significantly shorter among women (4.1 years vs 7.7 years; P = .02), and 71% of patients received anticancer therapy. The 1‐year and 3‐year survival rates for stage IIIB/IV were 25% and 0%, respectively. Grade 3/4 toxicities occurred in 60% of patients who received chemoradiation versus 36% of patients who received chemotherapy. Cancer‐related survival was better for patients with CD4 counts >200 cells/mL (P = .0298) and >500 cells/mL (P = .0076).CONCLUSIONS:The latency from diagnosis of HIV to lung cancer was significantly shorter for women. Although outcomes for patients with lung cancer who have HIV remain poor, a high CD4 count was associated with improved lung cancer‐related survival. Cancer 2012;. © 2011 American Cancer Society.