bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibiogram profiles of pathogenic and commensal bacteria in goat and sheep feces on smallholder farm
Authors: Basnet Ashesh , Kilonzo-Nthenge Agnes 
Published: May 2024

IntroductionThe increase of antimicrobial resistance (AMR) in zoonotic pathogens poses a substantial threat to both animal production and human health. Although large-scale animal farms are acknowledged as major reservoirs for AMR, there is a notable knowledge gap concerning AMR in small-scale farms. This study seeks to address this gap by collecting and analyzing 137 fecal samples from goat and sheep farms in Tennessee and Georgia.MethodBacteria were identified using culture-dependent methods and polymerase chain reaction (PCR), and antimicrobial susceptibility testing (AST) was performed using the Kirby-Bauer Disk Diffusion method.Results and discussionThe prevalence of E. coli (94.9%) in goats and sheep significantly exceeded (p &lt; 0.05) that of S. aureus (81.0%), Shigella (35.0%), S. saprophyticus, and Salmonella (3.0%). Salmonella occurrence in goat feces (2.2%) was higher than in sheep (0.8%). Notably, 27% of goats and 8% of sheep tested positive for Shigella spp., while 60% of goats and 21% of sheep tested positive for S. aureus. Antibiotic resistance was observed primarily against ampicillin (79.4%), vancomycin (65.1%), and gentamycin (63.6%), significantly surpassing (p &lt; 0.05) resistance to tetracycline (41.6%) and imipenem (21.8%). The penicillin (79.4%), glycopeptide (65.1%), and aminoglycoside (63.6%) antibiotic classes displayed significantly higher (p &lt; 0.05) resistance compared to tetracyclines (45.7%) and carbapenem (21.8%). Our findings suggest that goats and sheep feces may serve as source for multidrug-resistant bacteria, raising concerns about the potential introduction of their fecal matter into soil, water, and eventually to the food chain. This highlights the need for proactive measures to address and mitigate AMR in goats and sheep within small-scale farms.
Analisis Penerapan Metode User Centered Design dengan pengujian metode Cognitive Walkthrough
Authors: Haezrah Oktavini  , Reni Aryani  , Edi Saputra  , Ulfa Khaira  
Published: May 2024

Museum Siginjei Jambi merupakan salah satu di antara 439 museum di Indonesia yang menyimpan dan memamerkan berbagai macam koleksi peninggalan bersejarah maupun peradaban dari masa lampau dan merupakan bukti nyata sejarah yang pernah terjadi sehingga layak dijadikan sumber belajar dan kunjungan wisata. Tata Kelola Museum Siginjei Jambi masih bersifat traditional museum sehingga Museum Siginjei jambi perlu melakukan inovasi dengan menerapkan teknologi informasi berupa e-museum atau website untuk meningkatkan jumlah promopengunjung dan dapat diakses dengan cepat tanpa terkendala ruang dan waktu. Desain antarmuka merupakan hal penting yang perlu diperhatikan sebelum membuat website agar website yang dibuat dapat memenuhi kebutuhan pengguna. Peneliti membuat rancangan antarmuka website E-Museum Siginjei Jambi menggunakan metode user centered design karena dengan metode ini desain antarmuka yang dirancang berdasarkan masukan dari pengguna. Hasil pengujian desain yang telah dibuat dengan metode cognitive walkthrough dengan jumlah responden 5 orang adalah learnability 97,7%, error 1,77%, dan efficiency 94,3%.
An Analytical of the Design Process of Special Economic Zone Governance in Indonesia
Authors: Muzwardi* Ady , Fera Mirta , Maryam Siti 
Published: May 2024

Arun Lhoksumawe Special Economic Zone is an economic zone established as one of the economic growth centers of Aceh Province. In the planning, pre-operational, and operational processes, Arun Lhoksumawe Special Economic Zone still faces several significant problems. Therefore, the purpose of this qualitative research is to analyze the process of designing the governance of the Special Economic Zone. This analysis process is carried out through observation with secondary data from 2018 to 2019 as research support. The results of this study show that there are weaknesses in asset management that are not proportionally distributed so that collaboration and integration of assets are needed for the optimization of the Arun special economic zone. So, the results of this study can be used as evaluation material to optimize the Arun Lhoksumawe special economic zone.
Keyword: Special Economic Zones; Interest Groups; Co-operation; Assets; Arun
Big Data's Future Potential as an Innovation in Competitive Advantage and Decision-Making Techniques
Authors: Kusumah Armando , Sumarni Teti , Harto* Budi , Salim Agus 
Published: May 2024

This research highlights the challenges of big data integration in organisational decision-making processes, illustrating the gap between big data capabilities and their effective utilisation. An analytical descriptive qualitative method was used to study the use of big data in supporting sustainable innovation and competitive advantage of organisations in Indonesia. The results show that big data can improve the effectiveness of decision-making strategies by understanding market trends and consumer behaviour, which contributes to improving organisational performance and competitive advantage. These results are expected to contribute to the strategic management and innovation literature and encourage business practices in designing effective big data strategies to achieve sustainable competitive advantage.
Keywords: Big Data; Technological Innovation; Strategic Decision Making; Competitive Advantage; Sustainable Innovation
La guerre perdue des Khantes et des Nénètses des forêts (la soviétisation dans le district Ostjako-Vogul'sk, 1930-1938)
Authors: Samson-Normand de Chambourg Dominique 
Published: May 2024

The lost war of the Khanty and forest Nenets (the Sovietization in the Ostjako-Vogul’sk National District, 1930-1938)
The 1930s were of crucial importance in Russian history, especially when one considers the relationship between Soviet power and the indigenous peoples of Northwest Siberia. During ongoing administrative reorganization and as waves of newcomers arrived, willingly or not, Soviet authorities implemented policies designed to bring progress to the reindeer herders, hunters and fishermen of the tundra and the taiga - whether they liked it or not. These policies, which included collectivization, the creation of a network of culture centers, the introduction of schools, the imposition of plans for production, and the profanation of sacred spaces, were soon seen by many Nenets, Khanty and Mansi of the Ostjako-Vogul'sk national district (today autonomous Khanty-Mansi district) as a declaration of war. Indigenous peoples responded to the waves of arrests, the psychological threats and other interventions by local Soviet authorities with ritual gatherings, indigenous claims, and the pillaging and burning of the symbols of the Russian presence. Through consulting previously secret local archives and new publications and by making available information gathered during fieldworks among the Northern and Eastern Khanty, the Northern Mansi and forest Nenets in 2004, 2005, 2006, the author sheds light on the resilience of peoples who were thought by representatives of both the Empire and the Revolution to be near the point of extinction and who, paradoxically, were threatened in even more subtle ways by the repression of the mid-1930s.
Le commerce à Kiakhta des années 1840 à 1860
Authors: Edinarxova Nina 
Published: May 2024

Trade in Kiakhta in the 1840-1860s
In the 1840-I860s, Kiakhta was not only the biggest centre of commerce between China and Russia, but also the greatest Russian-Asian trading centre in general. Kiakhta’ s commerce contributed to the development of the Russian textile industry, and, consequently, played an important role leading up to the industrial revolution in Russia.
VALIDATION OF METHOD DETERMINING OF NICARBAZIN CONTENT IN FEEDS
Authors: Melikyan S. , Biront N. , Mysko G. , Yanovych D. 
Published: May 2024

The manuscript presents the validation of the developed high-performance liquid chromatography method for the determination of nicarbazin in animal feeding stuffs. Chromatographic separation was performed by means of HPLC RP columns packed with C18 (250×4.6 mm or 150×4.6 mm, 5 µm) using a mixture of acetonitrile and purified water as a mobile phase. The isocratic mode of elution was carried out for 10-15 min. Nicarbazin retention time depended on the eluent flow rate and ranged from 2.4 to 8.8 min. The repeatability of measurements was assessed by analyzing the calibration curve of nicarbazin standard solution. Feed samples were extracted with dimethylformamide. The samples were concentrated by drying, dry residues were reconstituted by the mobile phase, degreased with hexane and subjected to chromatographic separation. The specificity of the analytical method was tested by comparing the chromatographic separation of the feed sample spiked with nicarbazin standard solution with the control feed sample. The extraction degree of the spiked feed samples in the range of 20.0-50.0 mg/kg of nicarbazin was considered to determine the bias as the practical assessment of the validation parameters: trueness, linearity, repeatability and intermediate precision. The method was linear over this range of nicarbazin concentrations. The average degree of nicarbazin extraction from spiked feed samples is 99.1%. The correlation coefficient of the matrix matched calibration curve was more than 0.99. The evaluation of the intermediate precision of nicarbazin determination was estimated using different chromatographic columns over a long period of time. Validated HPLC-UV technique for the assay of animal feed and veterinary drugs based on nicarbazin has been introduced into the routine laboratory practice.
STUDY OF ACUTE AND SUB-ACUTE TOXICITY OF A MEDICATION BASED ON SPIDER VENOM EXTRACT
Authors: Patereha I. , Kushnir V. , Pyatnychko O. , Vynarchuk-Patereha V. , Chudyak M. 
Published: May 2024

Homeopathy is a regulatory therapy. The effectiveness of homeopathic therapy does not depend on the dose of the drug, but on the frequency of its repetitions. The composition of homeopathic preparations includes a wide range of natural and synthetic active substances: minerals; chemical substances; substances of plant origin; microorganisms, including fungi, bacteria, viruses, and plant parasites; substances of animal origin; and human materials, which may include tissues, secretions, hormones, and genetically homogeneous cell lines.
One such substance is an extract of spider venom (Tarantul cubensis D6), which remains active in pharmaceutical preparation for a long time. The drug is selectively absorbed in inflamed tissues, differentiating them from healthy cells and suppressing inflammation. The drug is also effective in necrotic and proliferative processes. It is used for the treatment of panaritium in the initial stage, skin ulcers, necrobacillosis, and necrosis of the soft tissues of the animal.
Any materials of animal or human origin are potentially dangerous for human and animal health, as they may contain toxic or pathogenic substances. Therefore, the study of the acute and subacute toxicity of spider venom extract is one of the stages of establishing the toxicological parameters of the drug.
The use of the drug in a therapeutic dose caused an increase in animal body weight, hemoglobin concentration, number of leukocytes, erythrocytes, hematocrit value, average erythrocyte volume (MCV), average hemoglobin content in erythrocytes (МСН), average concentration of hemoglobin in erythrocytes (МСНС), number of platelets, and AST activity against the background of a slight decrease in total protein content, creatinine, urea, and ALT activity.
The use of the drug in a 10-fold therapeutic dose caused an increase in animal body weight, creatinine, urea, ALT, and AST activity against the background of a decrease in the concentration of hemoglobin, the number of leukocytes and erythrocytes, the value of hematocrit, the average volume of erythrocytes (MCV), the average content of hemoglobin in erythrocytes (МСН), the average concentration of hemoglobin in erythrocytes (МСНС), the number of platelets, and the content of total protein.
VITAMINA B12 E SUA RELAÇÃO COM TRANSTORNO DEPRESSIVO MAIOR.
Authors: Lansing Cocconi Isabella , Pozza Huwe Laura Fernanda , Dhamer Thricy , Pozzobon Adriane 
Published: May 2024

A vitamina B12 é um nutriente essencial para o bom funcionamento do organismo. Além disso, estudos científicos têm sugerido uma possível relação entre a deficiência de vitamina B12 e a ocorrência de transtornos do humor, como o transtorno depressivo maior. O presente estudo teve como objetivo verificar a prevalência da dosagem de vitamina B12 entre adultos, e avaliar a relação entre os níveis de B12 relatados com a presença ou não de transtorno depressivo maior. A amostra avaliada foi constituída por 145 participantes que responderam um questionário estruturado. O transtorno depressivo maior foi avaliado pelo instrumento Patient Health Questionnaire-9. Resultados: A média de idade foi de 28,64 ±11,75 anos variando entre 18 e 66 anos. A média do IMC foi de 23,79± 3,78 kg/m2 indicando eutrofia. Os resultados fornecidos pelo PHQ-9 indicam que na amostra analisada a maioria apresentou transtorno mínimo e leve. Com relação à dosagem da vitamina B12, a maioria 73,8% referiu já ter dosado alguma vez a vitamina, porém somente 40% têm o hábito de dosar a vitamina regularmente. A média da vitamina B12 na amostra avaliada dos que referiram o valor foi de 362,11 ± 147,16 pg/mL. 53,8% referiu não fazer uso de suplementação com vitamina B12, contudo ao fazer uso da suplementação, 88,9% referiu se sentir melhor com o uso da vitamina B12. Diante do exposto pode-se inferir que na amostra avaliada que o transtorno depressivo maior é frequente dentre os jovens e que a dosagem da vitamina B12 é um parâmetro a ser considerado no acompanhamento, tendo em vista sua modulação sobre o sistema nervoso e influência em transtornos de humor.
The Effect of Marketing Mix on Purchase Intention in the Home Appliance Industry in West Java
Authors: Sari Dyah Puspita , Belgiawan Prawira Fajarindra 
Published: May 2024

The purpose of this research is to discover what factors influence someone's decision to purchase home equipment. In this study, a discussion was held about the effect of the 4P marketing mix elements on purchase intention. The product, the price, the place, and the promotion are the four marketing aspects that will be discussed in this paper. The respondents in this study were 234 people who met the requirements of being of productive age, living in West Java, and having a fixed income. SEM-PLS was used to analyze the data, and the results revealed that just three variables from the marketing mix affected customer purchase intention in the home appliances industry. Product, price, and promotion are the variables that influence purchase intention; however, place has no effect. The company can pay attention to these three variables while designing strategies to improve market competition.
Assessing knowledge, perceptions, and readiness of telemedicine recipients: A cross-sectional study
Authors: Hamdan Iman , Alkhader Enas 
Published: May 2024

Objectives: The current study aimed to assess the knowledge and perceptions of telemedicine recipients. Secondly, to evaluate their readiness towards adopting telemedicine in clinical settings.
Methods: A cross-sectional survey study was conducted in Jordan and designed to show the demographics of participants. The questionnaire was piloted for validity and reliability to achieve the aim of the study, and a collective of 420 participants were recruited.
Findings: Multiple regression analysis conducted showed that telemedicine services were significant at a level of α ≤ 0.05. Whereas the Pearson’s correlation of the dependent and independent variables was also significant at a level of α ≤ 0.05 as a function of age, working status, and income.
Conclusions: Regardless of the fact that participants showed a limited knowledge of telemedicine services, most of the participants expressed positive perceptions towards telemedicine services and its adoption in the clinical settings.
Mathematical modelling as a field of research: advances in the ecological analysis
Authors: Barquero Berta 
Published: May 2024

This paper focuses on the recent evolution of the field of mathematical modelling research and how different research questions have been formulated and addressed by international theoretical frameworks. This paper focuses on the “epistemological”, “economic” and “ecological” dimensions of these different theoretical approaches to mathematical modelling. We will see that the ecological issue is still largely absent from many approaches. This will allow us, in a second step, to show some tools of the anthropological theory of the didactic (ATD) such as the study and research paths (SRP) that we have been proposed to facilitate the design, implementation and analysis of modelling practices in different school levels and in teacher education.
Este artículo se centra en la evolución reciente del campo de la investigación en modelización matemática y en cómo se han formulado y abordado diferentes problemas de investigación en los distintos enfoques teóricos en el ámbito internacional. Nos centramos más concretamente en cómo los distintos enfoques teóricos a la modelización matemática abordan las dimensiones “epistemológica”, “económica” y “ecológica”. Mostraremos cómo la problemática ecológica sigue estando bastante ausente en muchos de estos enfoques. Esto nos permitirá, en la segunda parte, mostrar algunas herramientas de la teoría antropológico de lo didáctico (TAD), como los recorridos de estudio e investigación (REI) que han sido propuestos para facilitar el diseño, implementación y análisis de prácticas de modelización en distintos niveles escolares y en la formación de profesores.
Cet article s’intéresse à l’évolution récente du domaine de recherche sur la modélisation mathématique et la manière dont différentes questions de recherche ont été formulées et abordées par des cadres théoriques internationaux. Ce travail se focalise plus particulièrement sur les dimensions « épistémologique », « économique » et « écologique » de ces différentes approches théoriques de la modélisation mathématique. Nous verrons que la problématique écologique est encore en grande partie absente de nombreuses approches. Ceci permettra, dans un second temps, de montrer certains outils de la théorie anthologique du didactique (TAD) comme les parcours d’étude et de recherche (PER) que nous avons proposés pour faciliter la conception, la mise en œuvre et l’analyse des pratiques de modélisation dans différents niveaux scolaires et dans la formation des enseignants.
Teaching strategies for children with attention deficit hyperactivity disorder in English as foreign language classrooms
Authors: Cedillo Tello Maria Elizabeth , Argudo-Serrano Juanita Catalina 
Published: May 2024

This literature review focused on effective teaching strategies for children with Attention Deficit Hyperactivity Disorder (ADHD) in classrooms where English as a Foreign Language (EFL) is taught, which is undoubtedly a novel and crucial issue that demands immediate attention. This review not only concentrates on identifying the teaching strategies used for students with ADHD but also delves into and considers different teaching approaches and inclusive education adaptations for students with ADHD. The impact of this review might be significant for educators, parents, and stakeholders alike since it could provide valuable recommendations and knowledge based on the evidence gathered. This would lead to developing more effective, efficient, and inclusive teaching strategies or mechanisms for students with ADHD. Programs aimed at teacher training could also benefit from the findings of this review, contributing to the general support and improving the academic experience of students with ADHD in foreign language learning environments.
Integração curricular da extensão no ensino superior: dinâmica pedagógica curricularizada
Authors: Garcia Marisa Daniella Oliveira , Maia Sonia Cristina Ferreira 
Published: May 2024

O Princípio da Indissociabilidade entre Ensino, Pesquisa e Extensão, expresso na Constituição Federal, é uma diretriz para o funcionamento das Instituições de Ensino Superior (IES). Entretanto, a Extensão ainda precisa avançar administrativa e academicamente nas instituições de educação, seja por dificuldades na conquista de espaço em suas estruturas administrativas ou pelo lugar frágil que encontram nas diversas trajetórias acadêmicas. No contexto desse debate acerca da necessidade de valorização da Extensão nas IES, bem como da necessária conexão das Instituições com a sociedade, foi previsto no Plano Nacional de Educação (PNE) a obrigatoriedade da integração de ações extensionistas no currículo dos cursos de graduação. Posto isto, este estudo pretende apresentar uma dinâmica pedagógica da curricularização da extensão no ensino superior que possibilite desenvolver a interatividade, a conectividade, a interdependência existente entre todos os fenômenos da cultura, sendo compreendido e apresentado como diálogo permanente com o mundo do trabalho.
Association of E-Cadherin Expression with Histological Type and Grade of Gastric Adenocarcinoma
Authors: Nabi Nosheen , Omair Sidrah , Henna Azmat  , Iqra Butt  , Saira Javed  , Summaya Sohail  
Published: May 2024

Objectives: To determine the immune expression of E-Cadherin in gastric adenocarcinomas and its association with tumor histological type and grade to evaluate its prognostic significance.
Methodology: This descriptive cross-sectional study was conducted at the Pakistan Institute of Medical Sciences Islamabad, from December 2017 to January 2021. Eighty-one patients from both genders, aged 21 to 83 years, undergoing gastric biopsies and Gastrectomy specimens to diagnose gastric adenocarcinoma were included in our study. Immunohistochemical processing was performed and the results were interpreted by the consultant pathologist for the expression of E-cadherin on gastric adenocarcinoma. The data were analyzed with SPSS version 17.
Results: There was a significant statistical association between loss of E-Cadherin with histological type of adenocarcinoma (p = 0.000). In total 81 cases, there were 53 (65%) cases of intestinal type adenocarcinoma and 28 (35%) cases of diffuse type adenocarcinoma. Of the 28 cases with diffuse type gastric Adenocarcinoma, 10 cases showed complete loss of E-Cadherin. This complete loss of Cadherin was also seen in four out of 53 cases of intestinal adenocarcinoma, all of which were poorly differentiated intestinal type of adenocarcinomas. Total cases of well differentiated type of adenocarcinoma were nine; all of these showed high expression of E-Cadherin.
Conclusion: There is a strong association of E-Cadherin expression with the histological type and grade of gastric adenocarcinoma according to Lauren’s classification. As the grade of the adenocarcinoma gets higher there is more loss of E-Cadherin expression which proves its prognostic significance. It was also established that gastric adenocarcinoma is a disease of elderly with male predominance.