bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phonological evidence for morphological complexity in English proper names
Authors: Dabouis Quentin 
Published: May 2024

Cet article présente les résultats d’une analyse d’un important corpus de noms propres complexes anglais tels que Cambridge, Manchester ou Washington, et qui est inspirée de travaux existants sur les noms de lieux en néerlandais (Köhnlein 2015). Ces noms fournissent de nouvelles données montrant que les mots qui n’ont pas un sémantisme transparent peuvent se comporter phonologiquement comme des mots complexes. Ceci est démontré à partir de l’analyse des prononciations de plus de 3500 noms propres, au cours de laquelle huit propriétés phonologiques ont été étudiées. Les résultats montrent que ces noms propres ont des caractéristiques phonologiques qui sont plus semblables à celles des mots complexes (composés et mots à suffixes neutres) qu’à celles des mots sans structure interne. L’analyse que je propose suppose que ces mots sont effectivement complexes morphologiquement, et que cette complexité est reflétée dans la structure en domaines phonologiques. Cette structure interne est supposée acquise à travers l’exposition aux formes récurrentes qui forment ces noms propres ainsi qu’à travers l’identification de caractéristiques phonologiques « anormales ». Une possible représentation lexicale de ces mots est proposée. Celle-ci postule un stockage analytique de ces noms (Bermúdez-Otero 2012) et la coindexation entre les différents niveaux de représentation de l’entrée lexicale (Jackendoff 1997, 2002).
Sémantisme du nominal et de la position pré-nominale dans les dénominations de métiers du type high commissioner en anglais contemporain
Authors: Turlais Marie 
Published: May 2024

Dans cet article, nous mettons en évidence le sens porté par le constituant grammatical qu’on nomme le nominal, en particulier le sens du lien entre un nom-tête et une dépendance interne. La tête d’un nominal est une unité lexicale analysée comme un nom ; ce nom peut avoir pour dépendance pré-nominale des adjectifs ou des noms-dépendances. Dans les données étudiées, constituées de noms de métiers en deux mots tels que high commissioner ou top manager, les adjectifs adoptent en partie le sens procédural du nom, car ils participent à construire la catégorie à laquelle appartient le référent. À l’inverse, les noms-dépendances, s’ils conservent leur nature nominale, adoptent une certaine adjectivité : ils perdent leur indépendance référentielle et dénotent une propriété, explicitement attribuée au référent. Cet échange de propriétés nominales et adjectivales met en évidence le sens du nominal et de la position pré-nominale : le nominal construit une dénomination qui atteste d’une influence mutuelle des parties du discours, et qui génère une forte intégration des sens procéduraux des classes nominales et adjectivales. Le nominal signale l’intégration d’une entité et de sa propriété dans une dénomination conçue comme un bloc cohérent.
Énoncés capacitifs et constructions à sujet locatif : quel alignement syntaxe-sémantique ?
Authors: Lacassain Christelle , Marty Caroline 
Published: May 2024

Le présent article étudie deux constructions, capacitive (The main dining room seats 65) et à sujet locatif (The reign of Charles II saw the end of the great Forest courts), qui se prêtent à comparaison à plus d’un titre. Le sujet animé des constructions prototypiques des verbes à l’étude (seat et sleep, les deux verbes les plus employés pour le capacitif ; see et witness, les deux seuls verbes de ‘perception’ présents dans les constructions à sujet locatif) laisse place, dans ces constructions moins prototypiques, à un sujet inanimé locatif spatial, mais aussi temporel pour les constructions à sujet locatif. L’alignement entre fonction syntaxique et rôle sémantique n’y est pas prototypique car le référent du sujet n’est ni agent ni expérient, mais dénote, à première vue, une localisation spatiale ou temporelle. Enfin, ces deux types d’énoncés s’éloignent de l’expression d’une expérience et situation concrètes (ce que les verbes concernés dénotent habituellement).Cette étude interroge les mécanismes à l’œuvre dans les deux types de constructions, et montre que non seulement la différence d’alignement syntaxe-sémantique entre les énoncés prototypiques et les énoncés non prototypiques permet l’émergence d’une nouvelle signification verbale relevant de l’abstraction, mais qu’il existe aussi une logique de continuité entre les énoncés prototypiques (She slept well ou We saw a car with only one headlight on) et les énoncés non prototypiques. L’analyse de l’alignement syntaxe-sémantique présent dans ces deux types d’énoncés permet, dans un premier temps, d’identifier les déviations présentes à l’interface syntaxe-sémantique dans les constructions capacitives et à sujet locatif, puis de tenter de catégoriser plus précisément le type d’alignement à l’œuvre dans ces constructions, le constituant locatif thématisé n'étant ni un sujet, ni un topique habituel ; il est plutôt conçu comme un participant au procès à part entière, et non comme une circonstance. À la lumière de ces analyses, la motivation de cet alignement syntaxe-sémantique et de la topicalisation du locatif est mise au jour, de même que le sens à l’œuvre dans les deux types de constructions.
A Preliminary Sociophonetic Study on Schwa Epenthesis in Dublin English
Authors: Coupé Christophe 
Published: May 2024

Ce travail exploratoire propose d’étudier le phénomène d’épenthèse en anglais dublinois, et plus particulièrement l’épenthèse du schwa, à travers les productions orales contrôlées (listes de mots) de 65 Dublinoises et Dublinois enregistrés en 2021. Ce travail s’attachera premièrement à définir l’épenthèse du schwa, un phénomène caractéristique de l’anglais irlandais issu du substrat gaélique irlandais dont la structure phonotactique évite l’apparition d’agrégats consonantiques. Ces derniers sont « brisés » par l’insertion d’un schwa. La méthodologie mise en place dans l’analyse de l’épenthèse du schwa sera ensuite détaillée. Il s’agira d’aborder la constitution du corpus, les agrégats consonantiques étudiés en finale de mot (/rl/, /rm/, /rn/), ainsi que les critères perceptifs et acoustiques retenus dans l’identification de l’épenthèse. Les résultats seront présentés en fonction des variables retenues (âge, genre, origine géographique, mobilité) puis discutés. Sur près de 520 environnements, seuls 39 sont réalisés avec une épenthèse, l’agrégat /rl/ s’avérant être le plus propice à l’apparition de l’épenthèse dans le corpus. Cette étude montre que l’épenthèse est davantage présente chez les hommes que chez les femmes au sein de notre corpus. L’âge, l’origine géographique, la mobilité ou encore la maîtrise de l’irlandais ne semblent ainsi pas avoir d’influence sur la fréquence de réalisation de l’épenthèse du schwa en anglais dublinois.
Mitral Regurgitation Quantification, Management, and Guidelines: A 2024 Update
Authors: AlQouba Maryam , AlHumaidi Maha , Al Jarallah Mohammed , Dashti Raja , Khalil Mahmoud , Al Mulla Khalid , Sharma Riya Manas , Tse Gary , Rajan Rajesh 
Published: May 2024

Abstract
A comparison of the recommendations for the diagnosis and treatment of mitral regurgitation (MR), the second-most common valvular heart ailment in high-income countries, from the European Society of Cardiology/European Association for Cardio-Thoracic Surgery 2021 and American College of Cardiology/American Heart Association 2020 guidelines. We systematically reviewed and contrasted the guidelines on the diagnosis and treatment of MR to inform clinical judgment. A multimodal approach comprising a comprehensive history and physical examination, echocardiography, and, in some cases, cardiac magnetic resonance imaging, is the preferred method for diagnosis, treatment guidance, and follow-up in patients with valvular heart disease. Both guidelines agreed on the multidisciplinary approach of the heart team and the definition and grading of severe primary MR. There was substantial agreement on the thresholds for intervention, such as the onset of symptoms, left ventricular failure, and hypertrophy; however, there were differences among asymptomatic individuals with preserved ventricular function. While there was a consensus on the need for intervention in patients with severe secondary MR and those who continued to experience symptoms despite optimization of medical therapy, there was a disagreement regarding whether a transcatheter or surgical repair/replacement should be performed.
Analytical methods for honeybee venom characterization
Authors: El Mehdi Iouraouine , Falcão Soraia I. , Boujraf Saïd , Mustapha Harandou , Campos Maria G. , Vilas-Boas Miguel 
Published: May 2024

ABSTRACT
The discovery of new drugs has benefited significantly from the development of research in venomics, increasing our understanding of the envenomation processes. It has been previously reported that honeybee venom (HBV) exhibits several pharmacological activities such as anti-inflammatory, antibacterial, antimutagenic, radioprotective, and anticancer activity and may inclusively act as a complementary treatment for SARS-CoV-2. It composition consists mainly on melittin, phospholipase A2, and apamin but other constituents such as hyaluronidase, mast cell degranulating peptide and secapin are also relevant for its bioactivity. However, and because HBV is not officially recognized as a drug, until now, the international community did not establish quality standards for it. To uncover its exact composition, and boost the discovery of HBV-derived drugs, a significant number of techniques were developed. In this review, a relevant overview of the so far published analytical methods for HBV characterization is organized with the aim to accelerate its future standardization. The literature search was performed within PubMed, Google Scholar, and Science Direct by selecting specific documents and exploring HBV evaluation.
A systematic review
Authors: Hidayat Syahrul , Ibrahim Faisal Maulana , Suhandi Cecep , Muchtaridi Muchtaridi 
Published: May 2024

ABSTRACT
Non-small cell lung carcinoma (NSCLC) is a type of lung cancer with the highest prevalence and mortality rate worldwide. Many cases of this type of cancer are overexpression on epidermal growth factor receptor (EGFR). The use of currently available EGFR inhibitors as one of the treatment options for NSCLC still shows various shortcomings, especially the high failure rate of therapy due to resistance. It is important to find NSCLC drug candidates with EGFR inhibitory activity. There are various published articles and it is prominent to draw evidence-based scientific conclusions as a basis of decision-making to select potential compounds for further research. Polymer matrix composites and ScienceDirect are used as a database for article screening. Research using molecular docking method targeted to EGFR with parameters of Gibbs energy and amino acid interactions between ligands and drug targets are included in inclusion criteria. Compounds that achieve docking parameters and have comparable activity to NSCLC guideline drugs are conscientiously ranked. There are only 11 compounds that achieved the docking parameters and had comparable EGFR inhibitory potential. Top-rated compounds include 1,3,5-trisubstituted pyrazoline (3c), 1,3,5-trisubstituted pyrazoline (6c), 1,3,5-trisubstituted pyrazoline (8d), N-(3,4-Dimethylphenyl)-2-[(4-oxo-3-(4-sulfamoylphenyl)-3,4-dihydrobenzo[g] quinazolin-2-yl) thio] acetamide. The top-rated compounds can be used and considered for further research processes.
Mode action prediction of catechin from Uncaria gambir Roxb. against UDP-N-acetylenolpyruvyl-glucosamine reductase (MurB enzyme) of Streptococcus mutans
Authors: Dharsono Hendra Dian Adhita , Wibisono Lydiawati , Hayati Ayu Trisna , Apriyanti Eti , Satari Mieke Hemiawati , Kurnia Dikdik 
Published: May 2024

ABSTRACT
The prevalence of oral health problems in the global population is still high, especially dental caries, which is considered a multifactorial disease involving the role of bacteria, namely Streptococcus mutans. Gram-positive bacteria metabolize carbohydrates and sugars and convert them into lactic acid, causing dental caries. The peptidoglycan (PG) layer at the outer surface of the bacteria acts as protection. MurB enzyme is known for its contribution to PG biosynthesis. Gambir (Uncaria gambir Roxb.) is famous for many efficacies. Previous studies show that catechin from herb plants such as U. gambir has antibacterial activity. This study aimed to evaluate and predict the antibacterial activity of catechin from U. gambir against the MurB enzyme, which contributes to forming the bacteria PG, with an in silico approach. The structure of the MurB enzyme was collected from UniProt, and the ligands (catechin and chlorhexidine) structures were obtained from PubChem. The AutoDock software was used to dock both ligand and MurB enzyme visualized using PyMOL and analyzed using BIOVIA. The results showed that catechin has a binding affinity of more than − 7 kcal/mol against the MurB enzyme, and chlorhexidine has a higher binding affinity than catechin. Both catechin and chlorhexidine have similar amino acids attachment by hydrogen bonds. The results showed that catechin has competitive antibacterial activity against chlorhexidine in inhibiting the MurB enzyme.
Innovated formulation of oseltamivir powder for suspension with stability study after reconstitution using a developed ion-pair reversed phase high-performance liquid chromatography method
Authors: Hasson Kahtan Jassim 
Published: May 2024

ABSTRACT
Oseltamivir is an antiviral neuraminidase inhibitor used for the treatment and prophylaxis of influenza infection with viruses A and B. The mechanism of oseltamivir antiviral activity is by inhibiting the activity of the viral neuraminidase enzyme present on the surface of the virus, which stops viral replication and infectivity. Oral suspensions of oseltamivir phosphate are dispensed orally capsules and suspension. However, the use of oral suspension for pediatric administration is preferable and is prepared as a powder for suspension. The reconstituted suspension degrades rapidly within a few days. The objective of this work is to establish a stable formulation of oseltamivir phosphate as a suspension and to assure the stability conditions for prolonged use after reconstitution in aqueous form. In addition, this required formulation should maintain a high rate of dissolution, which subsequently leads to higher bioavailability. In this study, oseltamivir forms an inclusion complex with the natural and safe polymer hydroxypropyl beta-cyclodextrin, which resembles a host because its structural cavity carries the oseltamivir molecule in the aqueous preparation and provides a protective property against environmental challengers. In addition, a high-performance liquid chromatography (HPLC) stability-indicating method of analysis has been developed using an ion-pair reversed-phase HPLC technique that is validated for precision, accuracy, reproducibility, and specificity for the determination of oseltamivir in suspension. The results of this work show the relatively long shelf life of the reconstituted oseltamivir oral powder for suspension in the new pediatric formulation, and the developed HPLC method was precisely suitable for stability study.
Production, separation, and antimicrobial activity assessment of pristinamycin produced using date fruit extract as substrate
Authors: Hamad Siddig H. , Aleid Salah M. , Elgorashe Rafe E. , Babker Mohammed Y. 
Published: May 2024

ABSTRACT
Date fruits extract was assessed as substrate for pristinamycin production in shake flasks using Streptomyces pristinaespiralis DSMZ 40338 as production organism. A process of microfiltration, concentration, and solvent extraction was used to recover the antibiotic from the fermentation broth and its antimicrobial activity was tested using a well assay method. During a fermentation period of 120 h, the bacterium consumed approximately 28.4 g/l sugars, grew from 0.4 g/l to 4.0 g/l dry weight, and produced 51.0 mg/L pristinamycin. The microfiltration, concentration, and ethyl acetate solvent extraction applied resulted in 71% pristinamycin recovery. The antibiotic showed inhibition capacity comparable to that of the pristinamycins IA and IIA standards. The inhibited bacteria were Staphylococcus aureus, Escherichia coli, and Enterococcus faecium. Clear inhibition zones of 13.3–19.6 mm diameter were formed.
In vitro studies on the cytotoxicity, elastase, and tyrosinase inhibitory activities of tomato (Solanum lycopersicum Mill.) extract
Authors: Ambarwati Neneng Siti Silfi , Armandari Mari Okatini , Widayat Wahyu , Desmiaty Yesi , Elya Berna , Arifianti Ayun Erwina , Ahmad Islamudin 
Published: May 2024

ABSTRACT
Tomatoes (Solanum lycopersicum Mill.), a common vegetable in Indonesia, contain high levels of lycopene, which is good for the body. This research further investigates the activity of polar and nonpolar fractions of tomatoes as elastase and tyrosinase inhibitory, and cytotoxic agents. The extraction procedure used is maceration, fractionation through liquid-liquid fractionation, purification of phytochemical substances is achieved through the application of thin layer chromatography. Elastase and tyrosinase inhibitory activity was analyzed using spectrophotometry and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide cytotoxic assay. The result showed that the extract yield was 0.004%. The percentage of polar fraction from the extract was 2.58%, while the nonpolar fraction was 0.69%. The elastase inhibitory activity of polar and nonpolar fractions of tomato extract is 87.21% ± 7.57% and 73.12% ± 7.44%, respectively, The elastase inhibitory activity of polar and nonpolar fractions of tomato extract is 87.21% ± 7.57% and 73.12% ± 7.44%, respectively. The fractions had higher the anti-elastase activity than the positive control quercetin (65.97% ± 3.00%). The tyrosinase inhibitory activity of polar and nonpolar fractions of tomato extract is 23.71% ± 7.91% and 41.16% ± 5.41% (kojic acid as standard is 65.07% ± 0.86%), respectively. The IC50 of the cytotoxic assay to NIH 3T3 mouse embryonic fibroblast cells of the polar and nonpolar fraction of tomato extract is 1820.90 μg/mL and 1643.86 μg/mL, respectively.
Curcumin
Authors: Widjaja Sry Suryani , Rusdiana Rusdiana , Amelia Rina 
Published: May 2024

ABSTRACTThe ongoing, highly infectious COVID-19 pandemic has prompted various drugs, vaccines, and phytochemical research to control the disease. The accelerated development of vaccines showed the importance of immune boosters against the virus. This study aims to elucidate the role of curcumin, a phytochemical with an immunoediting profile potentially able to boost immunity after vaccination. Eighty participants were enrolled to receive curcumin supplementation (n= 40) and without (n= 40) after the first vaccination until 4 weeks after the second vaccination. Total antibody formation for SARS-CoV-2 was measured using an enzyme-linked immunosorbent assay 4 weeks after the second vaccination. The average antibody formed in groups treated with curcumin supplementation showed a statistically significant increase compared to the control group (262.6 ± 324.2 vs. 42.8 ± 53.5,P< 0.01). Age, sex, and comorbidities did not affect the production of antibodies within groups. Curcumin showed potential as a complementary supplementation during the period of vaccination as it can increase antibodies produced post vaccinations. Further investigation should be conducted on more subjects and a longer period in concordance to vaccine boosters and emerging new variants.
Prediction of the mechanism of action of catechin as superoxide anion antioxidants and natural antivirals for COVID-19 infection with in silico study
Authors: Zainuddin Achmad , Hidayat Ika Wiani , Kurnia Dikdik , Ramadhanty Zenika Febian , Padilah Rizal 
Published: May 2024

ABSTRACT
Coronavirus disease-2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus-2 attacking the lungs, which contain the most oxygen. The involvement of oxidative stress in the body and the role of antioxidant compounds, namely catechins, are thought to be able to prevent various diseases, including the COVID-19 infection virus. An in silico approach was employed between the catechins and the protein NADPH oxidase (Nox), followed by the coronavirus protease protein, to limit the generation of reactive oxygen species. This research using the in silico method seeks to predict the mechanism of action of catechin as a superoxide radical anion inhibitor and as an antiviral for COVID-19. This study carried out molecular docking simulations of catechin compounds against Nox and coronavirus proteases and then compared them with positive controls GKT136901 and remdesivir. The binding energy of catechin and Nox in a docking simulation is − 8.30 kcal/mol, which is somewhat lower than GKT136901's binding value of − 8.72 kcal/mol. Catechin and coronavirus proteases had binding energy of − 7.89 kcal/mol, which was greater than remdesivir's binding energy of − 7.50 kcal/mol. Based on in silico data, catechin as an antioxidant compound can be antiviral for COVID-19.
Serine racemase interaction with N-methyl-D-aspartate receptors antagonist reveals potential alternative target of chronic pain treatment
Authors: Laksono Ristiawan Muji , Kalim Handono , Rohman Mohammad Saifur , Widodo Nashi , Ahmad Muhammad Ramli 
Published: May 2024

ABSTRACT
Serine racemase (SR) catalyzes L-serine racemization to activate the N-methyl-D-aspartate receptor (NMDAR). NMDAR activation is associated with the progression of acute-to-chronic neuropathic pain. This study aimed to investigate NMDAR antagonist interactions with SR to obtain potential chronic pain target therapy. Several NMDAR antagonist drugs were obtained from the drug bank, and malonate was used as a control inhibitor. Ligands were prepared using the open babel feature on PyRx. The SR structure was obtained from Protein data bank (PDB) (3l6B) and then docked with ligands using the AutoDock Vina. Haloperidol had a lower binding affinity than malonate and other ligands. Ethanol had the highest binding affinity than other drugs but could bind to the Adenosine triphosphate (ATP)-binding domain. Haloperidol is bound to reface that function for reprotonation in racemization reaction to produce D-serine. Halothane bond with Arg135 residues aligned negatively charged substrates to be reprotonated properly by reface. Tramadol is bound to amino acid residues in the triple serine loop, which determines the direction of the SR reaction. Several NMDAR antagonists such as haloperidol, halothane, ethanol, and tramadol bind to SR in the specific binding site. It reveals that SR potentially becomes an alternative target for chronic pain treatment.
Optimization of microspheres containing virgin coconut oil and hydrolyzed virgin coconut oil as antimicrobial
Authors: Hariyadi Dewi Melani , Fitri Aldesra , Sudarma Sisunandar , Purwanti Tutiek , Erawati Tristiana 
Published: May 2024

ABSTRACT
Virgin Coconut Oil (VCO) with potential fatty acid content has a strong antibacterial effect for drug and cosmetics. VCO was hydrolyzed as hydrolyzed VCO (HVCO) to increase its activity. This study aims to optimize VCO and HVCO microspheres. Examination was included fatty acid content, density, and organoleptic. VCO and HVCO microspheres were characterized by yield, moisture content (MC), morphology, and size. Fatty acid content was done through gas chromatography mass spectrometry whereas for microspheres, effect of alginate concentration (1%–2%), and addition of poly ethylene glycol (PEG) were studied. VCO and HVCO microspheres formulas showed that an increase in polymer concentration, increasing yield, and improving MC. The most optimal 2% alginate with the addition of PEG increased yield up to 59% and reduced size. F4 microspheres resulted the highest yield, low MC, and high fatty acids. Morphology was spherical and smooth with small size. Optimization of HVCO microspheres showed its potential which recommend for antibacterial and antifungal activity.