bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analytical‐numerical Treatment of Elasticity and Thermoelasticity Problems for Inhomogeneous Orthotropic Cylindrical Bodies
Authors: Shevchuk Victor 
Published: March 2010

AbstractThis paper develops an approach to solving one‐dimensional elasticity and thermoelasticity problems for the case of inhomogeneous orthotropic cylindrical bodies. It is based on direct integration of differential equilibrium and compatibility equations in terms of stresses and reduction to the system of integral equations, which are effectively solved by the rapidly convergent iteration procedure. (© 2009 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Space‐Time Meshfree Collocation Method for PDEs
Authors: Netuzhylov Hennadiy , Zilian Andreas 
Published: March 2010

AbstractAn innovative Space‐Time Meshfree Collocation Method (STMCM) for solving systems of nonlinear ordinary and partial differential equations by a consistent discretization in both space and time is proposed as an alternative to established mesh‐based methods. The STMCM belongs to the class of truly meshfree methods, i.e. the methods which do not have any underlying mesh, but work on a set of nodes only, without an a priori node‐to‐node connectivity. A regularization technique to overcome the singularity‐by‐construction and to compute all necessary derivatives of the kernel functions is presented. The method combines the simplicity and straightforwardness of the strong‐form computational techniques with the advantages of meshfree methods over the classical ones, especially for coupled engineering problems involving moving interfaces. The key features of the proposed approach are: (i) no need to generate a mesh, (ii) simplified imposition of boundary conditions, (iii) no need to evaluate integral forms of governing equations, (iv) applicability to complex irregularly‐shaped domains. The proposed STMCM is applied to linear and nonlinear ordinary and partial differential equations of different types and its accuracy and convergence properties are studied. (© 2009 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A Numerical Model of a Drug Particle Dissolving in a Dissolution Test Apparatus
Authors: McMahon Niall M. , Crane Lawrence J. , Ruskin Heather J. , Crane Martin , D'Arcy Deirdre M. , Healy Anne‐Marie , Corrigan Owen I. 
Published: March 2010

AbstractThe dissolving compact, or tablet, is the most widely used method of drug delivery. Dissolution tests are used to ensure consistency during tablet manufacture, to assess the dissolution characteristics of a particular tablet design, to establish in vitro/in vivo correlations, and to predict how the drug will perform in the body. Dissolution tests also form a part of the drug approval process. The United States Pharmacopeia (USP) Type 2 Paddle Dissolution Apparatus,from here on referred to as the USP apparatus, is a standard dissolution test device, used by the Food and Drug Administration (FDA) and the pharmaceutical industry. Although the USP apparatus is much used, detailed theoretical descriptions of its characteristics are still not well developed. This work considers one possible end state of a dissolving tablet, i.e. fragmentation into small particles with dissolution continuing from the disintegrated solid masses. A framework for calculating the motion of and mass transfer from a drug particle moving through the USP apparatus is outlined. Calculations demonstrate that small particles move with the USP apparatus flow and that, for small particles below a critical diameter, natural convection and radial diffusion dominate, i.e. forced convection effects can be neglected for small particles. (© 2009 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)
The frequency transfer function corresponding to hand‐arm system
Authors: Pop A. F. , Arghir M. 
Published: March 2010

AbstractThe paper presents a study regarding the frequency transfer function corresponding to hand‐arm system. Theoretical the frequency transfer function obtains applying the Laplace function for the differential equations of moving system. This is a part of the study regarding the mechanical vibrations action over the hand‐arm system. (© 2009 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Brief preliminary design for a method of FMS machine tools subsystem selection
Authors: Gola Arkadiusz , Świć Antoni 
Published: March 2010

AbstractThe article presents the main points of methodology of machine tools subsystem selection for a flexible manufacturing system. In particular, it shows the main algorithm and stages of the methodology which is based on computer database systems, algorithms of elimination and method of multicriteria optimisation. (© 2009 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)
An L2 model for selfadjoint elliptic differential operators with constant coefficients on bounded domains
Authors: Behrndt Jussi , Rohleder Jonathan 
Published: March 2010

AbstractThe selfadjoint realization of a second order elliptic differential expression with Dirichlet boundary conditions is shown to be unitarily equivalent to the maximal multiplication operator with the independent variable in an explicit L2 model space. (© 2009 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Diagnostics of a combustion process in the aircraft radial engine
Authors: Gęca Michał , Litak Grzegorz , Wendeker Mirosław , Jakliński Piotr , Czarnigowski Jacek , Pietrykowski Konrad 
Published: March 2010

AbstractWe present the statistical nonlinear analysis of time series applied to indicated combustion pressure. Using nonlinear methods we analyzed dynamics of a multi cylinder aircraft radial engine in the presence of cyclic perturbations in a single cylinder. The perturbations have been caused by variation of an air/fuel ratio via injection timing. Identification of the disturbed cylinder has been done successfully by adopting wavelet and multifractal analysis. (© 2009 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Rapid fault‐tolerant control prototyping for mobile robots
Authors: Moczulski Wojciech , Panfil Wawrzyniec , Przystałka Piotr 
Published: March 2010

AbstractThe main purpose of the paper is to present a fault‐tolerant control system of an autonomous mobile robot. The authors present a framework for rapid prototyping of a behavior‐based control system relying on tools and technologies of the Microsoft R Robotics Developer Studio. Fault detection and isolation is carried out with the help of the model‐based and knowledge‐based diagnostics. The first approach is developed by applying recurrent neural networks for residual generation and fuzzy logic for their evaluation. The second approach depends on scalar feature estimation and fuzzy reasoning. Basing on this information rules represented in the form of a decision table are applied for robot's behavior reconfiguration. (© 2009 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)
An Analysis of Drug Dissolution Rates in the USP 24 Type 2 Apparatus
Authors: McDonnell David , Redmond Brendan , D'Arcy Deirdre M , Healy Anne Marie , Corrigan Owen I 
Published: March 2010

AbstractThis paper applies boundary layer theory to the process of drug dissolution in the USP 24, Type 2 Apparatus. The mass transfer rate from the top flat surface of a compact in various positions within the device is evaluated by means of a Pohlhausen integral method. (© 2009 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Descriptions of contacts in the presence of wear debris
Authors: Zmitrowicz Alfred 
Published: March 2010

AbstractThe mechanism of abrasive wear involves formation and circulation of debris particles detached from rubbing solids. The loose wear particles form a more or less continuous intermediate layer which separates the sliding surfaces. The layer is treated as a single continuum with own kinematics and constitutive relations. The removal of material from rubbing solids, continuum based models and granular models of wear debris are discussed in the contribution. (© 2009 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Study on the aluminium phosphate bonded SiC refractory performance and how it is influenced by oxidation and chemical attack
Authors: Pica E. M. , Rodean C. P. 
Published: March 2010

AbstractAluminium reduction cells service life and cell efficiency are strongly influenced by the side wall refractory lining. The aluminum phosphate bonded SiC refractories developed by us, instead of the carbon ones, have increased the cell capacity and productivity by the larger anode surfaces. In order to rank performances of various SiC products were carried out specific laboratory tests. The results of our research concerning materials made from aluminum phosphate bonded SiC showed that they are refractories with a high corrosion resistance and performances close to the bricks made of silicon nitride bonded silicon carbide. By extrapolation of the present study's results we can anticipate an increased service life of electrolysis cells that have such side walls. (© 2009 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Structural Analysis on Nanoscale
Authors: Wackerfuß Jens 
Published: March 2010

AbstractAtomic structures, exhibiting a physical dimension in a range of 1‐100 nanometers provide a basis for novel applications in nanotechnology. In molecular mechanics the formalism of the finite element method can be exploited to analyze the behavior of atomic structures in a computational efficient way. Based on the atom‐related consideration of the atomic interactions, a direct correlation between the type of the underlying interatomic potential and the design of the related finite element has been developed. Each type of potential is represented by a specific finite element. A general formulation that unifies the various finite elements is proposed. The mesh generation can be performed using well‐known procedures typically used in molecular dynamics. Although adjacent elements overlap, a double counting of the element contributions (as a result of the assembly process) can not occur a priori in this new formulation. As a consequence, the assembly process can be performed efficiently line by line. The presented formulation can easily be implemented in standard finite element codes and can be applied to various interatomic potentials. As an example, the method is applied in order to model the structural response of pristine and defective carbon nanotubes. (© 2009 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Influence of the machine structure on micro milling process
Authors: Shi Yinuo , von Wagner Utz , Mahr Frederik , Uhlmann Eckart 
Published: March 2010

AbstractTo achieve accurate machining using the micro milling process, precise tools (diameter range 0.2 mm–2 mm) are used. Because of the special properties of the micro milling tools and the related machine structures, it is not enough to assign the classical technique in macro milling process, e.g. stability prediction respecting only the dynamics of the tool/workpiece, directly to analyze the micro milling process. It is proved to be required also to take characteristics of the entire machine structure into account. Therefore, the mechanical vibration research of the micro milling machine structure is necessary, and subsequently the modeling of the structure as a multiple body system is described. The identification of the natural frequencies of a micro milling machine structure by means of the classical modal analysis is shown, and the influence of the structure is verified by comparing the surface roughness of the manufactured workpiece in experimental testings. (© 2009 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Non‐linear hypotheses of deformation of flat cross sections of elastic sandwich beam.
Authors: Magnucka‐Blandzi Ewa 
Published: March 2010

AbstractThe main goal of the paper is a comparison of three non‐linear hypotheses of deformation of flat cross sections of an elastic sandwich beam. Three‐layered simply supported beam is under uniformly distributed load (pressure). Studied beam has two faces and a metal foam core. Mechanical properties of the isotropic metal foam core of the beam vary across the thickness of the beam. Fields of displacements (geometric models of non‐linear hypotheses) are described. The results of solution of the deflection problem are presented at Figures. (© 2009 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Development of a quadratic element formulation based on the X‐FEM and NURBS surfaces
Authors: Haasemann Georg , Kästner Markus , Prüger Stefan , Ulbricht Volker 
Published: March 2010

AbstractThe FE‐simulation of inhomogeneous structures such as composite materials, biological tissues or foams requires the generation of respective finite element meshes. The Extended Finite Element Method (X‐FEM) allows for an efficient modelling technique where the element boundary needs not to be aligned to the interfaces. In this paper, a new plane element based on the X‐FEM and quadratic shape functions will be presented. This element allows for the description of curved material interfaces inside the element domain. The computation of the element stiffness matrix requires a numerical integration process which accounts for the discontinuous fields. In the case of a curved interface, the triangulation of the element domain as applied for linear element formulations is inappropriate. Hence, Non‐Uniform Rational B‐Spline (NURBS) surfaces are used to evaluate the integrals numerically. Finally, the results of different examples will show the properties and the quality of this element formulation. (© 2009 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Dynamical effects at material instability phenomena
Authors: Béda Peter B. 
Published: March 2010

AbstractIn a phenomenon called the Portevin‐Le Chatelier (PLC) effect negative rate dependence is coupled with the appearance of a self‐sustained oscillatory behavior in solid bodies. When PLC is treated as a type of dynamic material instability, the tools of the theory of dynamical system can be applied. The results of such investigation lead to an interpretation of PLC as a flutter type of loss of stability. (© 2009 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Nanoindentation Experiments at Elevated Temperatures for the Determination of Mechanical Solder Material Properties
Authors: Müller Wolfgang H. , Worrack Holger , Sterthaus Jens , Wilden Johannes 
Published: March 2010

AbstractThe continuous effort of modern electronic industry is the miniaturization of microelectronic components. In order to guarantee the reliability of the joining process, the quantitative knowledge of the solder material properties is very important, especially the values of Young's modulus, Nanoindentation hardness and yield stress. However, small‐sized microelectronic devices require the fabrication of small sized specimens and the use of corresponding miniature material tests. At the Technische Universität Berlin nanoindentation tests are applied. Moreover the material properties at elevated temperature are of particular interest in order to characterize the solder materials more detailed. This work describes the setup and the elevation of high‐temperature nanoindentation tests in context with first results for selected materials. (© 2009 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Numerical simulation of a multi‐contact detection technique for foreign particles in closed food containers
Authors: Osorio Anuhar , Schmidt Tobias , Beronov Kamen , Forstner Judith , Benning Rainer , Delgado Antonio 
Published: March 2010

AbstractIn the presented work the basis of a novel method for detecting foreign solid inclusions in closed glass bottles and cans containing liquid food are presented. The new method is based on an automatic recording and analysis of multi‐contact oscillatory signals of the food‐container‐particle (F‐C‐P) system. In this work, two different active mechanisms for positioning the foreign particles next to the wall of the bottle are studied and relevant numerical simulations are presented. In the first case, a bottle filled with water moves linearly with constant acceleration, while in the second case the bottle rotates around its longitudinal axis at a constant angular velocity. The obtained numerical results permit the selection of optimal locations for the detection system components. (© 2009 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Identification of unusual truncated forms of nucleocapsid protein in MDCK cells infected by Avian influenza virus (H9N2)
Authors: Liu Ning , Song Wenjun , Wang Pui , Lee Kim‐Chung , Cai Zongwei , Chen Honglin 
Published: March 2010

AbstractUnusual truncated forms of nucleocapsid protein (NP) were identified in the lysate of MDCK cells infected by Avian influenza virus (H9N2) using MS‐based proteomics approach. Moreover, O‐sulfonation that was considered as an unusual modification was identified in one of the tryptic peptides from the truncated NP. The findings might have implications on better understanding on the role of nucleoprotein in Avian influenza virus–host interaction.
Evaluation of blood collection tubes using selected reaction monitoring MS: Implications for proteomic biomarker studies
Authors: Randall Sarah A. , McKay Matthew J. , Molloy Mark P. 
Published: March 2010

AbstractAn emphasis of current proteomic research is the validation of plasma protein biomarkers. The process of blood collection itself is critical to the accuracy and reproducibility of quantitative biomarker assays. We have developed selected reaction monitoring (SRM) assays to analyse thirteen abundant plasma proteins and evaluated the impact of three different blood collection tubes on the levels of these proteins. We also assessed the implications of the time taken to analyse plasma samples by evaluating the recovery of these proteins. We showed that SRM detects minor differences in the levels of some proteins which can be attributed to collection tube type. The average recovery for 12 of 18 assays was higher for proteins that were collected in tubes containing protease inhibitors compared to conventional collection tubes. For five of the assays, the differential recovery was statistically significant. Delaying MS analysis of a freeze‐thawed sample for 1 hour showed greatly reduced recovery of these analytes; however differences attributed to tube type were only evident at the baseline timepoint. Finally, we assessed the natural variation of circulating levels of these proteins in a cohort of seven healthy individuals. This study provides useful information for researchers contemplating blood collection for undertaking protein biomarker studies.
Human galectin‐3 interacts with two anticancer drugs
Authors: Bogoeva Vanya P. , Varriale Antonio , John Constance M. , D'Auria Sabato 
Published: March 2010

AbstractHuman galectin‐3 (hGal‐3) is a mammalian lectin involved in regulation of RNA splicing, apoptosis, cell differentiation, and proliferation. Multimerized extracellular hGal‐3 is thought to crosslink cells by binding to glycoproteins and glycosylated cancer antigens on the cell surface or extracellular matrix. Fluorescence spectroscopy and circular dichroism were used to study the interaction of hGal‐3 with two anticancer agents: bohemine and Zn porphyrin (ZnTPPS4). The dissociation constant (kD) for binding of bohemine with hGal‐3 was kD 0.23±0.05 μM. The hyperbolic titration curve indicated the presence of a single bohemine binding site. The binding of ZnTPPS4 to hGal‐3 (with and without lactose) is of high affinity having kD=0.18–0.20 μM and is not inhibited by lactose, indicating that ZnTPPS4 and carbohydrate bind different sites. Circular dichroism spectra of the hGal‐3 complexes suggested that the binding of the hydrophobic compounds changed the hGal‐3 secondary structure. In summary, we show that two compounds with anticancer activity, bohemine and ZnTPPS4, have high affinity for hGal‐3 at a site that is distinct from its carbohydrate site. Since hGal‐3 binds to several carbohydrate cancer antigens, the results suggest that it may have utility in the targeted delivery of drugs for cancer.
Modifications of human total serum N‐glycome during liver fibrosis–cirrhosis, is it all about immunoglobulins?
Authors: Klein André , Michalski Jean‐Claude , Morelle Willy 
Published: March 2010

AbstractThe study of the total serum N‐glycome during liver cirrhosis has demonstrated numerous alterations. The identification of the glycoproteins carrying these modifications and their relative contribution to the modification of the total serum N‐glycome has shown the important role of IgA and IgG. The possible mechanisms of glycosylation alteration of the Igs and of liver secreted glycoproteins, the consequences in the pathophysiology of cirrhosis and their relation to the biomarkers of liver diseases are also discussed in the present review.
A water‐soluble parthenolide analogue suppresses in vivo prostate cancer growth by targeting NFκB and generating reactive oxygen species
Authors: Shanmugam Rajasubramaniam , Kusumanchi Praveen , Cheng Liang , Crooks Peter , Neelakantan Sundar , Matthews William , Nakshatri Harikrishna , Sweeney Christopher J. 
Published: March 2010

AbstractBACKGROUNDTo characterize the molecular changes associated with DMAPT‐induced prostate cancer cell death and its in vivo activity.METHODSCWR22Rv1 and PC‐3 were subjected to flow cytometry, electrophoretic mobility shift assays, and Western blot studies to measure DMAPT's ability to generate reactive oxygen species (ROS), inhibit NFκB DNA binding, and cause changes in anti‐apoptotic proteins. N‐acetyl cysteine (NAC) and short hairpin RNA (shRNA) were used to determine the contribution of ROS and JNK2 activation, respectively. The BrdU incorporation assay was used to measure proliferation and trypan blue studies assessed cell viability after DMAPT treatment. The in vivo activity of DMAPT as a single agent and in combination with bicalutamide or docetaxel was assessed in a subcutaneous xenograft model with athymic nude female mice.RESULTSDMAPT generated ROS with subsequent JNK activation and inhibited NFκB DNA binding and expression of NFκB‐regulated anti‐apoptotic proteins. DMAPT increased necrotic and apoptotic cell death in a cell‐type‐dependent manner and both types of cell death were blocked by NAC. Additionally, shRNA JNK2 partially blocked the anti‐proliferative activity of DMAPT. DMAPT inhibited CWR22Rv1 and PC‐3 cellular proliferation by 100% with 10 and 20 µM respectively and in vivo, DMAPT was more effective at inhibiting growth than biclutamide (CWR22v1) and docetaxel (PC‐3).CONCLUSIONSDMAPT promotes cell death by both generating ROS and inhibition of NFκB. Its in vivo activity supports the conduct of clinical trials in patients with castrate‐resistant disease. Prostate 70: 1074–1086, 2010. © 2010 Wiley‐Liss, Inc.
Study of phase change memory cell with inserting buffer layer
Authors: Wu Liangcai , Zhou Xilin , Song Zhitang , Liu Yan , Ni Henan , Gong Yuefeng , Rao Feng , Yao Donglin , Liu Bo , Song Sannian , Feng Songlin 
Published: March 2010

AbstractTiO2 and HfO2 with different electrical conductivity were used as buffer layer for phase change memory (PCRAM) cell, where Si‐Sb‐Te alloy was used as storage medium in the PCRAM cell. The electrical properties of the cells with and without buffer layer were compared through resistance‐voltage measurements. It is found that the PCRAM cell with both TiO2 and HfO2 buffer layer has relative low operation voltage. Furthermore, the inserting TiO2 buffer layer can also improve the device stability. It is considered that buffer layer with suitable electrical conductivity is needed for the PCRAM cell, especially in future high density storage. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)