bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of physiological noise in resting state fMRI using machine learning
Authors: Ash Tom , Suckling John , Walter Martin , Ooi Cinly , Tempelmann Claus , Carpenter Adrian , Williams Guy 
Published: November 2011

AbstractWe present a technique for predicting cardiac and respiratory phase on a time point by time point basis, from fMRI image data. These predictions have utility in attempts to detrend effects of the physiological cycles from fMRI image data. We demonstrate the technique both in the case where it can be trained on a subject's own data, and when it cannot. The prediction scheme uses a multiclass support vector machine algorithm. Predictions are demonstrated to have a close fit to recorded physiological phase, with median Pearson correlation scores between recorded and predicted values of 0.99 for the best case scenario (cardiac cycle trained on a subject's own data) down to 0.83 for the worst case scenario (respiratory predictions trained on group data), as compared to random chance correlation score of 0.70. When predictions were used with RETROICOR—a popular physiological noise removal tool—the effects are compared to using recorded phase values. Using Fourier transforms and seed based correlation analysis, RETROICOR is shown to produce similar effects whether recorded physiological phase values are used, or they are predicted using this technique. This was seen by similar levels of noise reduction noise in the same regions of the Fourier spectra, and changes in seed based correlation scores in similar regions of the brain. This technique has a use in situations where data from direct monitoring of the cardiac and respiratory cycles are incomplete or absent, but researchers still wish to reduce this source of noise in the image data. Hum Brain Mapp , 2013. © 2011 Wiley Periodicals, Inc.
Molecular imaging of breast tumors using a near‐infrared fluorescently labeled clusterin binding peptide
Authors: Filfil Rana , Paul‐Roc Béatrice , Cantin Christiane , Iqbal Umar , Tolkatchev Dmitri , Vinogradova Anna , Xu Ping , Ni Feng , O'Connor‐McCourt Maureen D. , Lenferink Anne E.G. 
Published: November 2011

AbstractSeveral reports have shown that secreted clusterin (sCLU) plays multiple roles in tumor development and metastasis. Here, we report on a 12‐mer sCLU binding peptide (designated P3378) that was identified by screening a phage‐display peptide library against purified human sCLU. Differential resonance perturbation nuclear magnetic resonance using P3378 and a scrambled control peptide (designated P3378R) confirmed the P3378‐sCLU interaction and demonstrated that it was sequence specific. P3378 and P3378R peptides were conjugated to an Alexa680 near infrared fluorophore (NIRF) and assessed for their tumor homing abilities in in vivo time‐domain fluorescence optical imaging experiments using living 4T1 tumor bearing BALB/c mice. When injected in separate animals, both peptides accumulated at the tumor site, however the NIRF‐labeled P3378 peptide was retained for a significant longer period of time than the P3378R peptide. Similar observations were made after simultaneously injecting the same tumor‐bearing animal with a peptide mixture of P3378 DyLight (DL)680 and the P3378R‐DL800. Coinjection of P3378‐DL680 with excess unlabeled P3378 blocked tumor accumulation of fluorescent signal while excess P3378R control peptide did not confirming the sequence specificity of the tumor accumulation. Finally, ex vivo fluorescence microscopy of these tumors confirmed the presence of P3378‐DL680 in the tumor and its colocalization with CLU. These results confirm the tumor targeting specificity of the P3378 CLU‐binding peptide and suggest its usefulness for the in vivo monitoring of solid tumors secreting detectable levels of CLU.
pH‐based cation exchange chromatography in the capture and elution of monoclonal antibodies
Authors: Ng Paul K. , Snyder Mark A. 
Published: November 2011

AbstractCation exchange chromatography separates adsorbed proteins by controlling the salt concentration or the mobile phase pH. This study examines the pH‐based method for binding and elution of monoclonal antibodies (MAbs). Five different clones with isoelectric points from 6 to 9 were evaluated. We performed our studies using a new chromatography resin (Nuvia™ S), which has high binding capacity. A three‐column process incorporating Nuvia S as a capture step was also demonstrated for the purification of MAb from tissue culture fluid. Chromatography performance of Nuvia S was demonstrated in a 50‐cycle study.
Fault‐tolerant spanners for ad hoc networks
Authors: Satyanarayana D. , Rao S. V. 
Published: November 2011

SUMMARYSpanners for ad hoc networks provide several benefits such as low communication cost and resource consumption. These spanners need to be fault tolerant in resource‐constrained ad hoc networks. In this paper, we have proposed three spanners, called fault‐tolerant local Delaunay triangulation (FTLDel), fault‐tolerant relative neighborhood graph (FTRNG), and fault‐tolerant Gabriel graph (FTGG). The fault‐tolerant spanners provide reliability to the network by avoiding heavy packet loss and retaining useful geometric properties. The performance of fault‐tolerant spanners FTLDel, FTRNG, and FTGG are evaluated using the network simulator ns2.28. Copyright © 2011 John Wiley & Sons, Ltd.
Home healthcare nurse retention and patient outcome model: discussion and model development
Authors: Ellenbecker Carol Hall , Cushman Margaret 
Published: November 2011

ellenbecker c.h. & cushman m. (2011) Home healthcare nurse retention and patient outcome model: discussion and model development. Journal of Advanced Nursing68(6), 1881–1893.AbstractAim.  This paper discusses additions to an empirically tested model of home healthcare nurse retention. An argument is made that the variables of shared decision‐making and organizational commitment be added to the model based on the authors’ previous research and additional evidence from the literature.Background.  Previous research testing the home healthcare nurse retention model established empirical relationships between nurse, agency, and area characteristics to nurse job satisfaction, intent to stay, and retention. Unexplained model variance prompted a new literature search to augment understanding of nurse retention and patient and agency outcomes.Data sources.  Data come from the authors’ previous research, and a literature search from 1990 to 2011 on the topics organizational commitment, shared decision‐making, nurse retention, patient outcomes and agency performance.Discussion.  The literature provides a rationale for the additional variables of shared decision‐making and affective and continuous organizational commitment, linking these variables to nurse job satisfaction, nurse intent to stay, nurse retention and patient outcomes and agency performance.Implications for nursing.  The new variables in the model suggest that all agencies, even those not struggling to retain nurses, should develop interventions to enhance nurse job satisfaction to assure quality patient outcomes.Conclusion.  The new nurse retention and patient outcome model increases our understanding of nurse retention. An understanding of the relationship among these variables will guide future research and the development of interventions to create and maintain nursing work environments that contribute to nurse affective agency commitment, nurse retention and quality of patient outcomes.
Immediate versus early non‐occlusal loading of dental implants placed flapless in partially edentulous patients: A 3‐year randomized clinical trial
Authors: Merli Mauro , Moscatelli Marco , Mariotti Giorgia , Piemontese Matteo , Nieri Michele 
Published: November 2011

AbstractAimTo compare immediate versus early non‐occlusal loading of dental implants placed flapless in a 3‐year, parallel group, randomized clinical trial.Materials and MethodsThe study was conducted in a private dental clinic between July 2005 and July 2010. Patients 18 years or older were randomized to receive implants for fixed partial dentures in cases of partial edentulism. The test group was represented by immediate non‐occlusal implant loading, whereas the control group was represented by early non‐occlusal implant loading. The outcome variables were implant failure, complications and radiographic bone level at implant sites 3 years after loading, measured from the implant–abutment junction to the most coronal point of bone‐to‐implant contact. Randomization was computer‐generated with allocation concealment by opaque sequentially numbered sealed envelopes, and the measurer was blinded to group assignment.ResultsSixty patients were randomized: 30 to the immediately loaded group and 30 to the early loaded group. Four patients dropped out; however, the data of all patients were included in the analysis. No implant failure occurred. Two complications occurred in the control group and one in the test group. The mean bone level at 3 years was 1.91 mm for test group and 1.59 mm for control group. The adjusted difference in bone level was 0.26 mm (CI 95% −0.08 to 0.59, p = 0.1232).ConclusionThe null hypothesis of no difference in failure rates, complications and bone level between implants that were loaded immediately or early at 3 years cannot be rejected in this randomized clinical trial.
Urinary tract infections in children and the risk of ESRF
Authors: Round Jeff , Fitzgerald Anita C , Hulme Claire , Lakhanpaul Monica , Tullus Kjell 
Published: November 2011

AbstractAims:  Paediatric guidance on diagnosis and treatment of urinary tract infections (UTIs) has in the past largely focused on identifying children with vesicoureteral reflux, thought to be at greatest risk of renal scarring. This practice has been questioned, specifically the accepted association between UTI and end‐stage renal failure (ESRF) through renal scarring. The aim of this article is to ascertain whether we can predict with confidence the true level of risk that a child with a first‐time UTI will subsequently develop ESRF attributable to UTI.Methods:  Using data available from renal registries, an analytical approach based on previous estimates of risk is used to demonstrate the range of plausible estimates of risk that can be generated and levels of uncertainty that surrounds those estimates.Results:  Estimates of the perceived risk of developing ESRF following UTI range from 1/154 to 1/199 900 and are heavily dependent on the assumptions made and the source of data.Conclusion:  There is considerable uncertainty in the relationship between childhood UTI and risk of ESRF based on the data currently available. Until further evidence is available, clinicians will continue to debate the risk of UTI and ESRF and consensus opinion will continue to guide management.
The experiences of nurse practitioners providing health care to the homeless
Authors: Seiler Ashley J. , Moss Vicki A. 
Published: November 2011

AbstractPurpose: Homelessness is a growing public health and social concern in our society. The purpose of this qualitative descriptive study was to gain insight into the unique experiences of nurse practitioners (NPs) who provide health care to the homeless.Data sources: Audio‐taped, open‐ended interviews were conducted with nine NPs from southeast and northeast Wisconsin.Conclusions: Five themes and 13 subthemes emerged from the NPs’ accounts. The main themes included: (1) why they do what they do; (2) a unique population with unique needs; (3) NP characteristics; (4) how the relationship develops; and (5) lessons learned: a relationship of reciprocity.Implications for practice: Study findings will assist healthcare providers to gain insight into the experience of providing health care to the homeless and learn what it takes to become successful in such an important and much needed role.
Moist versus Dry Baroclinic Instability in a Simplified Two-Layer Atmospheric Model with Condensation and Latent Heat Release
Authors: Lambaerts Julien , Lapeyre Guillaume , Zeitlin Vladimir 
Published: November 2011

AbstractThe authors undertake a detailed analysis of the influence of water vapor condensation and latent heat release upon the evolution of the baroclinic instability. The framework consists in a two-layer rotating shallow-water model with moisture coupled to dynamics through mass exchange between the layers due to condensation/precipitation. The model gives all known in literature models of this kind as specific limits. It is fully nonlinear and ageostrophic. The reference state is a baroclinic Bickley jet. The authors first study its “dry” linear instability and then use the most unstable mode to initialize high-resolution numerical simulations of the life cycle of the instability in nonprecipitating (moisture being a passive tracer) and precipitating cases. A new-generation well-balanced finite-volume scheme is used in these simulations.The evolution in the nonprecipitating case follows the standard cyclonic wave-breaking life cycle of the baroclinic instability, which is reproduced with a high fidelity. In the precipitating case, the onset of condensation significantly increases the growth rate of the baroclinic instability at the initial stages due to production of available potential energy by the latent heat release. Condensation occurs in frontal regions and wraps up around the cyclone, which is consistent with the moist cyclogenesis theory and observations. Condensation induces a clear-cut cyclone–anticyclone asymmetry. The authors explain the underlying mechanism and show how it modifies the equilibration of the flow at the late stages of the saturation of the instability. In spite of significant differences in the evolution, only weak differences in various norms of the perturbations remain between precipitating and nonprecipitating cases at the end of the saturation process.
In Situ Observation of Wacker-type Reaction System in Organic Solvent by X-ray Absorption Fine Structure (XAFS) Analysis
Authors: Okuoka Shin-ichi , Akatsuka Takeo , Miyoshi Yasuyuki , Tsukajima Aki , Saito Makoto , Yonehara Koji 
Published: November 2011

Abstract
The in situ observation of a Wacker-type reaction system has been conducted by X-ray absorption fine structure (XAFS) analysis, revealing the ligand exchange on palladium from trifluoroacetato to alkene and reoxidation of a palladium/alkene complex by copper proceed in organic solvent.
Polyacrylonitrile‐based electrospun carbon paper for electrode applications
Authors: Yang Ying , Simeon Fritz , Hatton T.Alan , Rutledge Gregory C. 
Published: November 2011

AbstractPolyacrylonitrile (PAN)‐based carbon paper with fiber diameters of 200–300 nm was developed through hot‐pressing, pre‐oxidation, and carbonization of electrospun fiber mats. Changes in morphology, crystallinity, and surface chemistry of the hot‐pressed carbon paper were investigated. More junctions between fibers were formed with increasing hot‐press time, which is attributed to melting and bonding of fibers. The bulk density increased to 0.5–0.6 g/cm3, which could help to improve the volume energy density for electrode applications. The conductivity of the carbon paper was found to be about 40 S/cm when the surface area was ∼ 2 m2/g, and depends not only on the conductivity of the individual nanofibers but also on the contacts between the nanofibers. The performance of the electrospun carbon paper as an electrode for electrochemical reactions involving ferrocene molecules was affected by the preparation protocol: the higher surface area of the electrodes formed with shorter hot‐press times provided a higher current generated per unit mass than that obtained with electrodes prepared using longer hot‐press time, but electrodes prepared with longer hot‐press times exhibited higher electrical conductivity and faster electron transfer kinetics. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
A pattern language for developing privacy enhancing technologies
Authors: Hafiz Munawar 
Published: November 2011

SUMMARYA privacy enhancing technology (PET) is an application or a mechanism that allows users to protect the privacy of their personally identifiable information. Early PETs were about enabling anonymous mailing and anonymous browsing, but lately, there have been active research and development efforts in many other problem domains. This paper describes the first pattern language for developing PETs. Currently, it contains 12 patterns. These privacy patterns are not limited to a specific problem domain; they can be applied to design anonymity systems for various types of online communication, online data sharing, location monitoring, voting, and electronic cash management. The pattern language guides a developer when he or she is designing a PET for an existing problem or innovating a solution for a new problem. Copyright © 2011 John Wiley & Sons, Ltd.
Primary roles of two dehydrogenases in the mannitol metabolism and multi‐stress tolerance of entomopathogenic fungus Beauveria bassiana
Authors: Wang Zheng‐Liang , Lu Jiang‐dong , Feng Ming‐Guang 
Published: November 2011

SummaryKnockout and complement mutants of mannitol‐1‐phosphate dehydrogenase (MPD) and mannitol dehydrogenase (MTD) were constructed to probe the roles of both enzymes in the mannitol metabolism and multi‐stress tolerances of entomopathogenic fungus Beauveria bassiana. Compared with wild‐type and complement mutants, ΔBbMPD lost 99.5% MPD activity for reducing fructose‐6‐phosphate to mannitol‐1‐phosphate while ΔBbMTD lost 78.9% MTD activity for oxidizing mannitol to fructose. Consequently, mannitol contents in mycelia and conidia decreased 68% and 83% for ΔBbMPD, and 16% and 38% for ΔBbMTD, accompanied by greatly enhanced trehalose accumulations due to 81−87% decrease in their neutral trehalase expression. Mannitol as mere carbon source in a nitrate‐based minimal medium suppressed the colony growth of ΔBbMTD instead of ΔBbMPD, and delayed more conidial germination of ΔBbMTD than ΔBbMPD. Based on median lethal responses, conidial tolerances to H2O2 oxidation, UV‐B irradiation and heat stress at 45°C decreased 38%, 39% and 22% in ΔBbMPD, and 18%, 16% and 11% in ΔBbMTD respectively. Moreover, ΔBbMPD and ΔBbMTD lost 14% and 7% of their virulence against Spodoptera litura larvae respectively. Our findings highlight the primary roles of MPD and MTD in mannitol metabolism and their significant contributions to multi‐stress tolerances and virulence influential on the biocontrol potential of B. bassiana.
Single port laparoscopic right colonic resection using a ‘vessel‐first’ approach
Authors: Lai C. W. , Edwards T. J. , Clements D. M. , Coleman M. G. 
Published: November 2011

AbstractAim  Single port laparoscopic colorectal surgery (SPLC), performed through a single incision of ≤ 3 cm, has been shown to be feasible. This study aimed to assess its safety and efficacy when used as the method of choice for right hemicolectomy.Method  A prospective study was carried out of patients undergoing right hemicolectomy using a single port laparoscopic technique. They were compared with a historical series of patients undergoing right hemicolectomy using a multiport laparoscopic technique. Between December 2009 and September 2010, single port surgery replaced conventional laparoscopic colorectal surgery (LCS) for radical medial to lateral right hemicolectomy performed by a single surgeon. Histology, length of hospital stay, complications, conversions and readmissions were recorded.Results  Fourteen patients were treated using single port laparoscopic surgery (SPLC): 10 for carcinoma (Dukes A1, B6, C3) and four for Crohn’s disease. Twelve patients were treated using multiport laparoscopic colorectal surgery (LCS): eight for carcinoma (Dukes B4, C3, Carcinoid 1), three for Crohn’s disease and one for adenoma. The median (interquartile range) operative time for the SPLC group was 120 (90–135) min and for the LCS group was 135 (116–150) min. The median (interquartile range) length of hospital stay was 3.5 (2.0–5.0) days for the SPLC group and for the LCS group was 4.0 (3.8–7.0) days. The median (interquartile range) number of lymph nodes removed for SPLC patients was 14.5 (9.8–19.5) and for the LCS patients was 14.5 (13.0–19.5). There were no conversions, no complications and no readmissions in either group.Conclusion  These data confirm the feasibility of the technique. Furthermore they suggest that it is safe and efficacious.
Mechanism of HIV antiretroviral drugs progress toward drug resistance
Authors: Ammaranond Palanee , Sanguansittianan Sayompoo 
Published: November 2011

AbstractThe rapid replication rate of HIV‐1 RNA and its inherent genetic variation have led to the production of many HIV‐1 variants with decreased drug susceptibility. The capacity of HIV to develop drug resistance mutations is a major obstacle to long‐term effective anti‐HIV therapy. Incomplete suppression of viral replication with an initial drug regimen diminishes the clinical benefit to the patient and may promote the development of broader drug resistance that may cause subsequent treatment regimens to be ineffective. The increased clinical use of combination antiretroviral treatment for HIV‐1 infection has led to the selection of viral strains resistant to multiple drugs, including strains resistant to all licensed nucleoside analog RT inhibitors and protease inhibitors. Therefore, it is important to understand the influence of such mutations on viral properties such as replicative fitness, fidelity, and mutation rates. Although research continues to improve our understanding of resistance, leading to refined treatment strategies and, in some cases, improved outcome, resistance to antiretroviral therapy remains a major cause of treatment failure among patients living with HIV‐1.
Association analysis between the −2518MCP‐1(A/G) polymorphism and generalized aggressive periodontitis in a Chinese population
Authors: Zhu X. L. , Meng H. X. , Zhang L. , Xu L. , Chen Z. B. , Shi D. , Feng X. H. , Zhang X. 
Published: November 2011

Zhu XL, Meng HX, Zhang L, Xu L, Chen ZB, Shi D, Feng XH, Zhang X. Association analysis between the −2518MCP‐1(A/G) polymorphism and generalized aggressive periodontitis in a Chinese population. J Periodont Res 2012; 47: 286–292. © 2011 John Wiley & Sons A/SBackground and Objective:  It has been suggested that aggressive periodontitis has a genetic basis. Monocyte chemoattractant protein 1 (MCP‐1) plays a critical role in the recruitment of monocytes and the development of periodontitis. The −2518MCP‐1(A/G) polymorphism has been implicated as a risk or susceptibility factor for a variety of autoimmune conditions and inflammatory diseases. The intent of this investigation was to study whether the −2518MCP‐1(A/G) polymorphism is associated with generalized aggressive periodontitis in the Chinese population.Material and Methods:  One hundred and twenty‐four patients with generalized aggressive periodontitis and 94 healthy subjects were included in this case–control study. Genomic DNA was isolated from a peripheral blood sample obtained from each subject. Gene polymorphisms of −2518MCP‐1(A/G) were analyzed by a standard polymerase chain reaction–restriction fragment length polymorphism (PCR‐RFLP) assay. A logistic regression analysis was performed to test the association between the −2518MCP‐1(A/G) genotype (alleles) and generalized aggressive periodontitis with adjustment of the major covariates (gender, age and smoking status).Results:  There was no significant association of the −2518MCP‐1(A/G) polymorphism with generalized aggressive periodontitis in the unstratified subjects. However, when patients were stratified by gender, the frequency of the G+ genotype was significantly lower in female patients with generalized aggressive periodontitis compared with female controls (p = 0.036, adjusted odds ratio = 0.3, 95% CI: 0.1–0.9). In female patients with generalized aggressive periodontitis, the probing pocket depth was larger in subjects with the AA genotype than in subjects with the G+ genotype (5.07 mm vs. 4.30 mm; Z = −2.470, p = 0.014).Conclusion:  The polymorphisms of −2518MCP‐1 may play an important role in determining generalized aggressive periodontitis susceptibility in this cohort of Chinese women.