bluuebunny/crossref_metadata_2025_split huggingface dataset:
Telehealth use for sexual and reproductive health promotion and care during the early phase of COVID-19 pandemic: A descriptive-interpretive qualitative study of healthcare providers’ perspectives and experiences in Western - Central New York State
Authors: Muheriwa-Matemba Sadandaula Rose , Alcena-Stiner Danielle C. , Glazier Alexander , LeBlanc Natalie M. 
Published: May 2024

AbstractTelehealth emerged as an option for the provision of sexual and reproductive health (SRH) care and promotion during COVID-19 pandemic restrictions. However, studies are limited on the perspectives and experiences of healthcare providers (HCPs) practicing in the Western-Central region of New York State. This qualitative interpretive study explored the perspectives and experiences of HCPs with telehealth use for sexual and reproductive health promotion including counselling, testing, care and treatment for HIV infection and other sexually transmitted infections (STIs), in Western New York State. Ten HCPs participated in semi-structured in-depth interviews from October 2019-February 2021. These providers were predominately white, female, ranged in years of clinical experience (1-30 years). The narratives revealed three major themes: 1) healthcare providers’ perspectives of telehealth use, 2) healthcare providers’ experiences with telehealth use for SRH promotion and care, and 3) determinants of telehealth implementation. Though all providers reported an increase in the use of telehealth, experiences in the delivery of telehealth varied especially for sexual and reproductive health services. Some providers reported having more time to consult with patients because of a decrease in patient load which freed up time to engage with patients. Others reported technological limitations among some patients which impacted care. Strengthening telehealth-based sexual health promotion will serve to address efforts toward ending the HIV epidemic, reducing other STIs, and ensuring consistent access to contraception. To effectively implement telehealth findings, suggest a need to ensure adequate technological resources for patients, and a need to increase HCPs’ comfort to engage patients in sexual health conversations via telehealth.
Plasma p-tau217 in Alzheimer’s disease: Lumipulse and ALZpath SIMOA head-to-head comparison
Authors: Pilotto Andrea , Quaresima Virginia , Trasciatti Chiara , Tolassi Chiara , Bertoli Diego , Mordenti Cristina , Galli Alice , Rizzardi Andrea , Caratozzolo Salvatore , Zancanaro Andrea , Contador José , Hansson Oskar , Palmqvist Sebastian , Santis Giovanni De , Zetterberg Henrik , Blennow Kaj , Brugnoni Duilio , Suárez-Calvet Marc , Ashton Nicholas J , Padovani Alessandro 
Published: May 2024

ABSTRACTBackgroundPlasma phosphorylated-tau217 (p-tau217) has been shown to be one of the most accurate diagnostic markers for Alzheimer’s disease (AD). No studies have compared the clinical performance of p-tau217 as assessed by the fully automated Lumipulse and SIMOA ALZpath p-tau217.AimTo evaluate the diagnostic accuracy of Lumipulse and SIMOA plasma p-tau217 assays for AD.MethodsThe study included 392 participants, 162 with AD, 70 with other neurodegenerative diseases (NDD) with CSF biomarkers and 160 healthy controls. Plasma p-tau217 levels were measured using the Lumipulse and ALZpath SIMOA assays. The ability of p-tau217 assessed by both techniques to discriminate AD from NDD and controls was investigated using ROC analyses.ResultsBoth techniques showed high internal consistency of p-tau217 with similar correlation with CSF p-tau181 levels. In head-to-head comparison, Lumipulse and SIMOA showed similar diagnostic accuracy for differentiating AD from NDD (area under the curve [AUC] 0.952, 95%CI 0.927–0.978 vs 0.955, 95%CI 0.928–0.982, respectively) and HC (AUC 0.938, 95%CI 0.910-0.966 and 0.937, 95% CI0.907-0.967 for both assays).ConclusionsThis study demonstrated the high precision and diagnostic accuracy of p-tau217 for the clinical diagnosis of Alzheimer’s disease using either fully automated or semi-automated techniques.
Measuring linkage disequilibrium and improvement of pruning and clumping in structured populations
Authors: Bercovich Ulises , Rasmussen Malthe Sebro , Li Zilong , Wiuf Carsten , Albrechtsen Anders 
Published: May 2024

AbstractStandard measures of linkage disequilibrium (LD) are affected by admixture and population structure, such that loci that are not in LD within each ancestral population appear linked when considered jointly. The influence of population structure on LD can cause problems for downstream analysis methods, in particular those that rely on LD pruning or clumping. To address this issue, we propose a measure of LD that accommodates population structure using the top inferred principal components. We estimate LD from the correlation of geno-type residuals and prove that this LD measure remains unaffected by population structure when analyzing multiple populations jointly, even with admixed individuals. Based on this adjusted measure of LD, we can perform LD pruning to remove the correlation between markers for downstream analysis. Traditional LD pruning is more likely to remove markers with high differences in allele frequencies between populations, which biases measures for genetic differentiation and removes markers that are not in LD in the ancestral populations. Using data from moderately differentiated human populations and highly differentiated giraffe populations we show that traditional LD pruning biasesFSTand PCA but that this can be alleviated with the adjusted LD measure. In addition, we show the adjusted LD leads to better PCA when pruning and that LD clumping retains more sites and the retained sites have stronger associations.
Self-Rehabilitation Strategy for Rural Community-dwelling Stroke Survivors in a Lower-Middle Income Country: A Delphi Study
Authors: Ibrahim Rabi’u , Joseph Conran , Stewart Aimée , Lawal Isa Usman 
Published: May 2024

AbstractBackgroundMore than half of stroke survivors in LMICs lack access to stroke rehabilitation services. The promotion of self-rehabilitation could be promising in an attempt to address the stroke rehabilitation inadequacies in LMICs. Self-rehabilitation interventions can easily be accepted by many community-dwelling stroke survivors, and therefore, have the potential to drive towards the successful realization of Sustainable Development Goals and other WHO rehabilitation goals. We report a consensus building process that sought to identify which task training is relevant to include in a task-specific self-rehabilitation strategy for the rural community-dwelling stroke survivors.MethodsWe used an iterative two-staged mixed-method consensus-building approach: (1) focus group discussions (n = 5) with rural community-dwelling stroke survivors were conducted to explore personal life experiences in performing daily activities, and the results were used to developed a lists of candidate task trainings that could be included in a task-specific self-rehabilitation intervention model for improving functional ability post-stroke survivors; (2) a three-round Delphi exercise with a panel of stroke rehabilitation experts to establish consensus on the importance/relevance of the developed task trainings. Consensus was pre-defined to be the point where the proportion of items giving a rating of 3 (quite relevant) or 4 (highly relevant) by raters would be ≥ 0.8.ResultsA list of 74 task training was generated from the results of the focus groups and grouped as follows: training for the upper extremity (37); lower extremity training (21); while 7 and 9 task trainings were grouped under the trunk and balance training respectively. A panel of 13 experts in the Delphi reviewed these task trainings and consensus was achieved on keeping 28 task trainings in the first round and an additional 7 in the second round. In the study team’s analysis of open text responses, several areas of debate were identified and some task trainings were modified. The exercise yielded 49 trainings (66% of 74) on which there was consensus (the mean proportion of items giving a rating of 3 or 4 by raters was 0.93) to keep 3 task training groups relating to: upper extremity (27), lower extremity/balance (8), trunk strength (4) and warm up exercises (10).ConclusionsThe study provides a consensus-based view of the features of a task-specific self-rehabilitation training strategy to improve outcomes following a stroke. This self-rehabilitation training strategy can be used as an intervention approach to augment and promote stroke rehabilitation among the rural community-dwelling stroke survivors, especially in SSA.
Dopamine and acetylcholine correlations in the nucleus accumbens depend on behavioral task states
Authors: Costa Kauê Machado , Zhang Zhewei , Zhuo Yizhou , Li Guochuan , Li Yulong , Schoenbaum Geoffrey 
Published: May 2024

SummaryDopamine in the nucleus accumbens ramps up as animals approach desired goals. These ramps have received intense scrutiny because they seem to violate long-held hypotheses on dopamine function. Furthermore, it has been proposed that they are driven by local acetylcholine release, i.e., that they are mechanistically separate from dopamine signals related to reward prediction errors. Here, we tested this hypothesis by simultaneously recording accumbal dopamine and acetylcholine signals in rats executing a task involving motivated approach. Contrary to recent reports, we found that dopamine ramps were not coincidental with changes in acetylcholine. Instead, we found that acetylcholine could be positively, negatively, or uncorrelated with dopamine depending on whether the task phase was determined by a salient cue, reward prediction error, or active approach, respectively. Our results suggest that accumbal dopamine and acetylcholine are largely independent but may combine to engage different postsynaptic mechanisms depending on the behavioral task states.
A gentle palette of plasma membrane dyes
Authors: Ling Jing , Liu Yitong , Fu Yunzhe , Liu Shuzhang , Ding Ling , Huang Lulu , Xi Peng , Chen Zhixing 
Published: May 2024

AbstractPlasma membrane stains are one of the most important organelle markers for unambiguous assignments of individual cells and monitoring membrane morphology and dynamics. The state-of-the-art PM stains are bright, specific, fluorogenic, and compatible with super-resolution imaging. However, when recording membrane dynamics, particularly under light-intensive microscopes, PM is prone to photodynamic damages due to its phospholipid bilayer nature. Here we developed PK Mem dyes tailored for time-lapse fluorescence imaging. By integrating triplet-state quenchers into the MemBright dyes featuring cyanine chromophores and amphiphilic zwitterion anchors, PK Mem dyes exhibited a three-fold reduction in phototoxicity and a more than four-fold improvement in photostability in imaging experiments. These dyes enable 2D and 3D imaging of live or fixed cancer cell lines and a wide range of primary cells, at the same time pair well with various fluorescent markers. PK Mem dyes can be applied to neuronal imaging in brain slices andin vivotwo-photon imaging. The gentle nature of PK Mem palette enables ultralong-term recording of cell migration and cardiomyocyte beating. Notably, PK Mem dyes are optically compatible with STED/SIM imaging, which can handily upgrade the routine of time-lapse neuronal imaging, such as growth cone tracking and mitochondrial transportations, into nanoscopic resolutions.
Liquid-like condensates that bind actin drive filament polymerization and bundling
Authors: Walker Caleb , Chandrasekaran Aravind , Mansour Daniel , Graham Kristin , Torres Andrea , Wang Liping , Lafer Eileen M. , Rangamani Padmini , Stachowiak Jeanne C. 
Published: May 2024

AbstractLiquid-like protein condensates perform diverse physiological functions. Previous work showed that VASP, a processive actin polymerase, forms condensates that polymerize and bundle actin. To minimize their curvature, filaments accumulated at the inner condensate surface, ultimately deforming the condensate into a rod-like shape, filled with a bundle of parallel filaments. Here we show that this behavior does not require proteins with specific polymerase activity. Specifically, we found that condensates composed of Lamellipodin, a protein that binds actin but is not an actin polymerase, were also capable of polymerizing and bundling actin filaments. To probe the minimum requirements for condensate-mediated actin bundling, we developed an agent-based computational model. Guided by its predictions, we hypothesized that any condensate-forming protein that binds actin could bundle filaments through multivalent crosslinking. To test this idea, we added an actin-binding motif to Eps15, a condensate-forming protein that does not normally bind actin. The resulting chimera formed condensates that drove efficient actin polymerization and bundling. Collectively, these findings broaden the family of proteins that could organize cytoskeletal filaments to include any actin-binding protein that participates in protein condensation.
Microwave photo-association of fine-structure-induced Rydberg
(n+2)D5/2nFJ
macro-dimer molecules of cesium
Authors: Bai Jingxu , Jiao Yuechun , Song Rong , Raithel Georg , Jia Suotang , Zhao Jianming 
Published: May 2024

Long-range (n+2)D5/2nFJ Rydberg macro-dimers are observed in an ultracold cesium Rydberg gas for 39≤n≤48. Strong dipolar flip (〈D5/2F5/2|V̂dd|F5/2D5/2〉, 〈D5/2F7/2|V̂dd|F7/2D5/2〉) and cross (〈D5/2F7/2|V̂dd|F5/2D5/2〉) couplings lead to bound, fine-structure-mixed (n+2)D5/2nFJ macro-dimers at energies between the FJ fine-structure levels. The (n+2)D5/2nFJ macro-dimers are measured by microwave photo-association from optically prepared [(n+2)D5/2]2 Rydberg-pair precursor states. Calculated adiabatic potential curves are used to elucidate the underlying physics and to model the macro-dimer spectra, with good overall agreement. Microwave photo-association allows Franck-Condon tuning, which we have studied by varying the detuning of a Rydberg-atom excitation laser. Further, in Stark spectroscopy, we have measured molecular DC electric polarizabilities that are considerably larger than those of the atomic states. The large molecular polarizabilities are unexpected and may be caused by high-ℓ mixing. The observed linewidths of the Stark-shifted molecular lines provide initial evidence for intramolecular induced-dipole-dipole interaction.

Published by the American Physical Society
2024
Gender differences in remote work: a study on the boundary management tactics of women and men
Authors: Shen Menghan , Zamani Efpraxia D. 
Published: May 2024

PurposeThe purpose of this study is to identify potential differences in experiences and their causes from a gender-based perspective.Design/methodology/approachWe use secondary data, and we conduct a thematic analysis, to identify whether and how women and men negotiate differently.FindingsDespite remote work being considered as creating a level-playing field for both genders, women are still vulnerable to work and life demands, and pre-existing stereotypes become exacerbated. In addition, we show how technology might be used to manage physical and temporal boundaries, through integration or segmentation tactics.Originality/valueThere is a growing body of literature that focuses on work-life conflict among teleworkers. Yet, there is limited research that explores such conflicts from a gender perspective, specifically whether and how different genders manage boundaries between work and life differently.
Teleworking and commuting mode choice in the post-COVID-19 era as a challenge for organisations
Authors: Hernández-Tamurejo Álvaro , Rodríguez Herráez Beatriz , Mora Agudo María Leonor 
Published: May 2024

PurposeThis empirical research aims to provide organisations with useful information on how teleworking has affected employee commuting, allowing organisations to adapt working conditions to the new social context. This research sets out to provide evidence on the behaviour of teleworkers in terms of the mode of transport chosen when commuting to work physically.Design/methodology/approachThis research is based on a survey conducted in Madrid based on a theoretical approach grounded in the theory of planned behaviour (TPB) and discrete choice models. Exploratory factor analysis (EFA) and discriminant analysis have been used to determine the variables that influence the mode of transport chosen by teleworkers when commuting in person.FindingsThe results indicate the prevalence of private car use by teleworkers when working at the office, finding that attitudes and satisfaction with modes of transport significantly influence their choice. The characteristics and frequency of teleworking, however, are not significant, which indicates that teleworkers attach greater importance to their preferred mode of transport, regardless of the disadvantages.Originality/valueThis research provides empirical evidence using an inductive approach to understand the challenges that organisations are facing with regard to teleworking since commuting behaviour has changed for teleworkers. This requires organisations to give significant reconsideration to the issue of commuting as an important component of working time that could condition employee satisfaction and, therefore, the retention or recruitment of talent. Furthermore, residence and mobility changes afford organisations better access for recruitment, notwithstanding urban planning implications.
An examination of corporate citizenship on customer loyalty in the banking industry: a PLS-SEM analysis
Authors: Ghorbanzadeh Davood 
Published: May 2024

Purpose
This research aims to address the need for a more in-depth empirical investigation of exploring the link between the adoption of corporate citizenship (CC) practices and different aspects of customer behavior in a developing country. Also, it develops a research framework and assesses the mediating role of brand image, brand love, brand reputation and brand trust between customer perceptions of CC and customer loyalty.

Design/methodology/approach
Working with a sample of 290 private bank customers in Iran, partial least square-based structural equation modeling is used to test the conceptual model.

Findings
The findings reveal significant and positive relationships between CC, brand image, love and reputation. Indirectly and in the relationship between CC and customer loyalty, there are significant relationships through the serial roles of image-reputation, image-love and image-trust. Most importantly, the findings add value to the current knowledge by exploring the mediating effect of brand image, love, reputation and trust between CC and customer loyalty. Finally, this study has resulted in an updated prediction model of private banking customer loyalty.

Originality/value
This study makes a unique theoretical contribution to the literature by evaluating and comparing the mediating role of image, love, reputation and brand trust between CC and customer loyalty using the hierarchy of effects model.
Treating traumatized children with intellectual disabilities: Tailoring Trauma‐Focused Cognitive Behaviour Therapy for a vulnerable population
Authors: Hoover Daniel W. , Fleming Tabitha C. , Khan Maria 
Published: May 2024

AbstractBackgroundChildren with intellectual disabilities are at heightened risk for traumatization, though underserved due to silos of care, diagnostic overshadowing, and lack of adapted treatment. Trauma‐Focused Cognitive Behavioural Therapy (TF‐CBT), an evidence‐based childhood trauma therapy, is described with recommended adaptations for use with children who have intellectual disabilities.MethodWe present a suggested theoretical and clinical guide for treating children with mild to moderate intellectual disabilities. We explicate key functional domains of intellectual disabilities—comprehension, executive functions, and generalization—as the basis for tailoring the treatment model.ResultsTherapy recommendations are organized into a heuristic ‘matrix’ of resources and adaptations to TF‐CBT components, based on clinical experience and research literature, illustrated with composite case vignettes.ConclusionChildren with intellectual disabilities are a uniquely vulnerable population historically excluded from clinical trauma interventions and research but can respond to adapted care. Considerations for future research and dissemination are discussed.
Microsporidia: Pervasive natural pathogens of Caenorhabditis elegans and related nematodes
Authors: Gang Spencer S. , Lažetić Vladimir 
Published: May 2024

AbstractThe nematode Caenorhabditis elegans is an invaluable host model for studying infections caused by various pathogens, including microsporidia. Microsporidia represent the first natural pathogens identified in C. elegans, revealing the previously unknown Nematocida genus of microsporidia. Following this discovery, the utilization of nematodes as a model host has rapidly expanded our understanding of microsporidia biology and has provided key insights into the cell and molecular mechanisms of antimicrosporidia defenses. Here, we first review the isolation history, morphological characteristics, life cycles, tissue tropism, genetics, and host immune responses for the four most well‐characterized Nematocida species that infect C. elegans. We then highlight additional examples of microsporidia that infect related terrestrial and aquatic nematodes, including parasitic nematodes. To conclude, we assess exciting potential applications of the nematode‐microsporidia system while addressing the technical advances necessary to facilitate future growth in this field.
Exploring the landscape of AI adoption in cosmetic medicine and surgery: Insights from the 25th IMCAS Congress (International Master Course in Aging Science)
Authors: Haykal Diala , Ascher Benjamin , Cartier Hugues , Gold Michael 
Published: May 2024

AbstractIntroductionThe integration of artificial intelligence (AI) into cosmetic medicine promises to revolutionize the field by enhancing diagnosis, treatment planning, and patient care.ObjectiveThis manuscript explores the current adoption and perceptions of AI among professionals in the realm of cosmetic dermatology and plastic surgery, utilizing insights from the IMCAS Congress 2024 attendees.MethodsA survey employing a digital questionnaire with 14 questions was distributed among attendees of the IMCAS Congress 2024 to evaluate their familiarity with AI, usage in clinical practice, perceived advantages, and concerns regarding data privacy and security.ResultsThe survey revealed that a majority of respondents are familiar with AI's potential in cosmetic medicine, yet there is a notable discrepancy between awareness and actual application in practice. Concerns over data privacy and a pronounced need for further training were also highlighted.ConclusionDespite recognizing AI's benefits in cosmetic medicine, significant barriers such as data privacy concerns and the need for more comprehensive training resources must be addressed. Enhancing education on AI‐applications and developing strategies to mitigate privacy risks are imperative for leveraging AI's full potential in improving patient care and outcome in cosmetic medicine.