bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Study of Drug Efficacy in the Treatment of Ovarian Cancer
Authors: Nishimura Haruo , Hamaguchi Kinya , Miyahara Kenichi , Miyoshi Tadashi , Higashijima Hiroshi , Yakushiji Michiaki 
Published: August 2010

AbstractOne hundred and nine cases of common epithelial ovarian cancer treated in our department during the past decade were entered into this study, which dealt with direct therapeutic effects and prognosis, comparing the groups administered cisplatin with those administered other anticancer drugs.

In 38 patients with measurable lesions, high response rates were achieved through the administration of anticancer drugs containing cisplatin in both the primary cancer and recurrent cancer groups.
Preventive chemotherapy was performed in patients in whom complete surgery was achieved at the initial operation. No significant difference in prognosis was observed through the administration of cisplatin and other anticancer drugs.
In patients in whom reduction surgery was carried out to the maximum possible degree at the initial operation, an improvement in prognosis was observed through the administration of cisplatin.

These results imply that a cisplatin‐based regimen should be aggressively used, except in cases that underwent complete debulking surgery.
Adenoid Cystic Carcinoma of the Cervix: A Report and Review of 3 Cases
Authors: Yokoyama Yasuhiro , Tamaya Teruhiko 
Published: August 2010

AbstractAdenoid cystic carcinoma was reported in 3 Japanese women. In all cases, the condition followed the same rapid pattern of deterioration described in previous literature. The characteristic cribriform pattern was observed in all patients under a microscope, even in small parts of the tumor. This finding of this tumor may indicate that the adenoid cystic carcinoma is not identical to, but a variation of an undifferentiated carcinoma derived from the reserve cell.
Contragestive Effects of the Antigestagenic Agent, RU486, in Rats and Rabbits
Authors: Tsujii Takashi , Kambegaaw Akira , Kobayashi Miwako , Arakawa Satoko , Okinaga Shoichi , Arai Kiyoshi 
Published: August 2010

AbstractThe contragestive effect of the antiprogesterone RU486 in pregnant rats and rabbits were investigated. Administrations of increasing doses of RU486 in intact or castrated pregnant rats induced abortion in a dose dependent manner. RU486 had less effect when administered on the 16th day of gestation. Antiestrogens (tamoxifen, clomiphene citrate), an inhibition of 3 β‐hydroxysteroid dehydrogenase (epostane) showed a synergistic effect when used in combination with RU486. A decrease in serum progesterone levels was observed after RU486 administration. A larger dose of RU486 was necessary to induce abortion in pregnant rabbits compared to rats. The maximum blood concentration was greater and the area under the plasma level curve was larger in rats than in rabbits following administration of RU486.
Localization and Significance of Fibronectin in Peri‐Implantation Mouse Embryos
Authors: Takeuchi Kazuhiro , Nagata Yukihiro 
Published: August 2010

AbstractThis study was performed with the aim of clarifying differences in the localization of fibronectin between embryos developed in vivo and in vitro together with the significance of fibronectin in embryos at implantation.Localization of fibronectin in the embryos was first found in the inner cell mass of the early blastocyst in utero (in vivo group). In contrast, when embryos were cultured in vitro from the 2‐cell to the blastocyst stage (in vitro group), fibronectin could not be observed in the late blastocyst.When the blastocysts developed either in vivo or in vitro were further culture for 3 days in Dulbecco's Modified Eagle Medium (D'MEM) containing 10% newborn calf serum, the in vitro implantation (trophoblastic outgrowth in vitro) rates were 90% and 37%, respectively. If the blastocysts developed in vivo were cultured in D'MEM alone, the in vitro implantation rate was as low as 29%. However, if fibronectin was added to the D'MEM, instead of newborn calf serum, the in vitro implantation rates were improved.These results led to the conclusion that fibronectin is necessary for the implantation of blastocysts.
Induction of Endogenous Cytokines in Ascites of Patients with Ovarian Cancer by OK‐432, A Streptococcal Preparation
Authors: Mori Hidehiro , Itoh Naoki , Yamada Yoshitaka , Tamaya Teruhiko 
Published: August 2010

AbstractTo clarify the action mechanism of OK‐432, OK‐432 was intraperitoneally (i.p.) administered to 4 ovarian cancer patients with malignant ascites. In 2 of the 4 patients, 4 types of cytokines (tumor necrosis factor, interleukin 1 β, interleukin 2, and interferon γ) were induced in ascites after intraperitoneal injection of OK‐432 (i.p. OK‐432). In one of these patients, the ascitic supernatant after i.p. OK‐432 significantly inhibited colony formation of autologous ascitic tumor cells; the amount of ascites decreased markedly, and the ascitic cytology became negative. In the other 2 patients, only interferon γ was induced in ascites after i.p. OK‐432. In these 2, ascitic supernatant did not inhibit colony formation of autologous ascitic tumor cells.These results indicated that i.p. OK‐432 can induce various endogenous cytokines in malignant ascites and that these induced cytokines may contribute to the antitumor effect of i.p. OK‐432.
Amniotic Rupture Sequence: Report of Five Cases
Authors: Lin Ho‐Hsiung , Wu Chih‐Cheng , Hsieh Fon‐Jou , Hsieh Chang‐Yao , Lee Tzu‐Yao 
Published: August 2010

AbstractAmniotic rupture sequence or amniotic band syndrome is a rare, non‐recurrent disease complex. We preferred the former term because its wide spectra of fetal malformation appear to depend on the timing and the consequent changes following a single event of amniotic rupture. However, the exact etiology and pathogenesis still remain obscure; and the disease is often mis‐ or under‐diagnosed, thus leading to inappropriate genetic counselling. Prenatal diagnosis is sometimes possible with the aid of ultrasound. We reported our experience of 5 cases of amniotic rupture sequence with special emphasis on different clinical pictures, possible pathogenesis and pathologic findings. Hopefully this will aid in the recognition of this disorder, thus offer appropriate genetic counselling to the patients.
Cryopreservation of Human Embryos as a Useful Tool for Infertile Couples
Authors: Katayama K. Paul , Stehlik Ed , Roesler Mark , Pentimalli Concetta , Gunnarson Cindy , Jagusch Susan , Meyer Matthew 
Published: August 2010

AbstractIn order to improve the pregnancy rate per oocyte retrieval while reducing the chance of multiple‐gestations, a technique of cryopreservation of human embryos was used for our initial study consisting of 100 infertile patients undergoing in vitro fertilization (IVF) procedure. These patients combined a “fresh” embryo transfer with cryopreservation. The embryos were cryopreserved with 1,2‐propanediol. Twenty‐nine (29%) patients achieved ongoing pregnancies from the fresh embryo transfer. Thirty patients received a transfer of thawed embryos in a natural cycle. Nine of these patients achieved ongoing pregnancies. Combining these 2 transfers results in a 38% ongoing pregnancy rate. Forty‐one patients have yet to receive their frozen embryos. The current success rate in this study indicates that over 50% of the patients in this group can expect to become pregnant by the time all the cryopreserved embryos have been transferred.
Maternal Mortality from Infection at a University Hospital in Nigeria
Authors: Adetoro Olalekan O. 
Published: August 2010

AbstractThis study analyzed 89 cases of maternal death following infections. The overall maternal mortality rate in infection was 5.9%. The maternal death rate is significantly related to parity but higher age group mothers survived better. Septicaemic shock and cardiopulmonary arrest were the major terminal causes of maternal death. The risk factors for the high maternal death following infections were examined and preventive measures recommended.
Case Report: Pregnant Woman with a Ventriculoperitoneal Shunt to Treat Hydrocephalus
Authors: Okagaki Atsuhiko , Kanzaki Hideharu , Moritake Kouzo , Mori Takahide 
Published: August 2010

AbstractA pregnant woman with hydrocephalus who required multiple revisions of a ventriculoperitoneal shunt is discussed. Her symptoms improved after the replacement of the ventriculoperitoneal (VP) shunt with a ventriculoatrial (VA) shunt, suggesting the benefits of ventriculoatrial shunting during pregnancy.
Vaginal Metastases in Gestational Trophoblastic Disease
Authors: Wong L. C. , Ngan H.Y.S. , Collins R. J. , Ma H. K. 
Published: August 2010

AbstractFrom 1976 to 1988, 320 patients with gestational trophoblastic disease were treated in the Department of Obstetrics and Gynaecology, University of Hong Kong. Eighteen patients had vaginal metastases. The clinical features and behaviour of the disease were analysed. The prognosis depends mainly on the extent of the disease. Similar favourable response to chemotherapy was observed in low‐risk patients with vaginal metastases.
In vitro and in vivo Induction of Squamous Cell Carcinoma Antigen (SCC) in a Uterine Cervical Cancer Cell Line (SKG‐IIIa) with Peplomycin and Sodium Butyrate
Authors: Nozawa Shiro , Kojima Masahiko , Tukazaki Katsumi , Sakayor Motoko , Iizuka Rihachi , Kagiyama Naoko 
Published: August 2010

AbstractIn order to investigate the effect of an antisquamous cell carcinoma drug, peplomycin, the new analogue of bleomycin, on the production of a squamous cell carcinoma‐associated tumor marker termed “SCC” (or TA‐4), we carried out in vitro and in vivo experiments using the uterine cervical epidermoid cancer cell line SKG‐IIIa, together with the investigation of the effect of sodium butyrate which was reported to be one of the representative gene modulators. In vitro production of SCC was biochemically and immunocytochemically confirmed in SKG‐IIIa cells. Immunocytochemistry using anti‐SCC antibody revealed that the total number of SCC‐positive cells increased after the treatment with peplomycin (1.6 fold) or sodium butyrate (1.5 fold). The total amount of SCC in cultured medium, intracellular SCC, and cell debris during 5 days of culturation also increased with peplomycin (1.8 fold) and sodium butyrate (1.4 fold). These data strongly suggest that SCC production of SKG‐IIIa cells is stimulated by peplomycin and sodium butyrate in vitro. In vivo experiments were also performed by administering peplomycin to nude rats with hetero‐transplanted tumors of SKG‐IIIa, and transient elevations of serum SCC level (113% to 238% of the initial values) were observed, suggesting that SCC production of cancer cells is also stimulated by peplomycin in vivo.
The Experience of Termination of Second Trimester Pregnancies Using Gemeprost Vaginal Pessaries in a District General Hospital
Authors: Lim B. H. , Mahmood T. A. , Lees D.A.R. 
Published: August 2010

AbstractExperience with the use of Gemeprost pessaries (prostaglandin E1 analogue), in a group of 60 consecutive patients for second trimester termination in a Scottish District General Hospital, is presented. Gestation ranged from 12 to 20 weeks; there were 29 nulliparous (48%) and 31 (52%) multiparous women. Fifty‐seven (95%) aborted within 36 hours; 29 (48%) aborted completely and did not require further uterine curettage. Nulliparous patients required more pessaries and the abortion was more often incomplete. Side effects were minimal. There were no serious problems; and antiemetics were required by 17% and parenteral analgesics by 13% of patients.
A Highly Sensitive and Specific Sandwich Enzyme Immunoassay for Detection of Human Chorionic Gonadotropin in Trophoblastic Disease
Authors: Ibuki Yoshito , Yazaki Katsumi , Igarashi Masao 
Published: August 2010

AbstractA highly sensitive and specific two‐site enzyme immunoassay (EIA) kit for human chorionic gonadotropin (hCG) has been examined and applied to the detection of hormones in the serum of normal individuals and patients with trophoblastic disease.This EIA uses a solid phase coupled antibody to the unique COOH terminal peptide region of the hCG β‐subunit (β‐CTP) and an enzyme conjugated monoclonal antibody to the hCG β‐subunit. The overnight 2 step assay measured as little as 0.2 mIU/ml serum without hLH interference and a rapid one step assay was newly developed in our laboratory. Assays of serum from normal men and nonpregnant women of reproductive age indicated that most individuals did not have detectable serum levels of hCG immunoreactivity, although a minority had minute amounts. In contrast, women with non‐functional ovaries had detectable levels of hCG immunoreactivity with a mean value of 0.86 mIU/ml serum.The extremely high sensitivity and specificity of the EIA in detecting hCG provides substantial advantages for the detection of early pregnancy and for monitoring trophoblastic tumors.
Analysis of False Negative Cytology by a Chromosome Study
Authors: Katayama K. Paul , Stafl Adolf , Woodruff J. Danald , Masukawa Teruo , Jones Howard W. 
Published: August 2010

AbstractForty‐two cases of pre‐invasive and invasive cancer of the cervix diagnosed by histology were studied cytologically and cytogenetically. Preinvasive lesions showed a good correlation between the cytologic impression and the histologic diagnosis. However, among 17 patients with invasive cancer, there were 2 completely negative cytologic impressions. These were in cases having modal chromosome counts of 47 and 48, respectively. This study demonstrates that some invasive cancers of the cervix are resistant to cytologic diagnosis because of their peridiploid chromosome counts and lack of anisokaryosis.
Oocyte Donation Program Using a Simplified Hormonal Regimen
Authors: Chang Yoon Seok , Kim Seok Hyun , Choi Young Min , Moon Shin Yong , Lee Jin Yong 
Published: August 2010

AbstractIt has been well recognized that both the synchronization of luteinizing hormone (LH) surge between the donor and the recipient for normally cycling women and the complex steroid replacement regimen given on a sequential and incremental basis for women with primary or secondary ovarian failure are two important aspects in oocyte donation. In oocyte donation program at SNUH, a simplified hormonal regimen applicable both to normally cycling women and to those with ovarian failure which consisted of administering 2 mg estradiol (E2) valerate orally 3 times a day augmented with 100 mg progesterone (P) in oil intramuscularly daily starting on the day preceding the oocyte retrieval from the donor was utilized. From July 1988 to December 1989 at SNUH, 11 cycles of oocyte donation program in 10 infertile patients were undertaken and 5 patients succeeded in pregnancy.
Ultrasonographic Monitoring of the Placenta in Patients with Bleeding during the First and Second Trimesters
Authors: Takeda Satoru , Baba Kazunori , Kojima Toshiyuki , Kinoshita Katsuyuki , Satoh Kazuo , Sakamoto Shoichi 
Published: August 2010

AbstractThirteen patients with vaginal bleeding in the first and second trimester, in 730 pregnancies confirmed with live fetuses, were diagnosed as having subchorionic hematoma at the perivillous or periplacental region by a real‐time B‐mode scan device. In 9 of the 13 patients, the hematoma disappeared within 1 to 3 months after detection, while in 2 patients it increased in size.Seven of the 13 pregnancies progressed to full term (53.8%), 3 ended in premature deliveries (23.1%) and 3 in spontaneous abortions (23.1%). In 5 of the 13 patients, PROM occurred. Pathological examinations revealed 5 circumvallate (38.5%) and 2 circummarginate (15.4%) placentas.Since our clinical observation indicates that subchorionic hematoma and marginal separation of the placenta may be important causes of bleeding during pregnancy, monitoring of the placenta and fetus by ultrasound was used to obtain precise information in order to manage patients with bleeding. It might be speculated that extrachorial placenta results from subchorionic hematoma or its absorption.
Massive Fetomaternal Hemorrhage: Case Report
Authors: Ishihara Hiroshi , Takahashi Hiroyuki , Takeuchi Yuichiro , Kigawa Junzo , Sawazumi Kazuhide , Ito Takashi , Maeda Kazuo 
Published: August 2010

AbstractMassive fetomaternal hemorrhage (FMH) is rare. Early diagnosis is important because FMH has a poor prognosis in the antepartum or early postpartum period. A case of massive FMH in which 400 ml blood was lost is presented here. Fetal anemia was suspected from the sinusoidal fetal heart rate pattern. The hemorrhage in the maternal circulation was diagnosed before delivery by using the Kleihauer‐Betke test. An emergency cesarean section was performed. The cord hemoglobin level was 3.7 g/dl. The baby's severe anemia was treated with a neonatal blood transfusion. In this case, the baby had a good clinical course. Early diagnosis and treatment of massive FMH are necessary for a good prognosis.
Cartier Loop Biopsy of the Cervix: A Retrospective Study of 6 Months' Experience with a One‐Year Follow‐Up*
Authors: von Dadelszen Peter , Peddie David J. , Wells J. Elisabeth 
Published: August 2010

AbstractNinety‐six women with cervical pathology underwent Cartier loop biopsy at Christchurch Women's Hospital, during the first 6 months of 1987. Eighty‐four (88%) patients had full follow‐up past 11 months, of whom 10 (12%) had dysplasia/CIN. Initial follow‐up (3–8 months) was achieved in 91 (95%) patients, of whom 11 (12%) had dysplasia/CIN. Follow‐up was predominantly by cytology. These rates were not significantly influenced by any single preoperative or operative factor. The implications of these results are discussed.
An Ethical Issue for Reproductive Technologies*
Authors: Poplawski Nicola K. 
Published: August 2010

AbstractThe establishment of “new birth technologies” (such as ovulation induction, in vitro fertilization and gamete intrafallopian transfer) has raised many ethical issues. One such issue is “selective fetal reduction”, a process advocated in the management of excessive multiple pregnancy. The ethics of “selective fetal reduction” involve consideration of not only the efficacy of the process and the destruction of fetuses per se, but more specifically consideration of the moral dilemma of destroying some fetuses for the probable benefit of the remainder. The latter I consider here.Following from this ethical analysis it is suggested that the law regarding abortion should permit selective reduction in high multiple pregnancies, that is pregnancies of 4 or above. I contend that the law should prohibit deliberate exposure (in an infertility programme) to significant risk of high multiple pregnancy, when there is full intention to reduce any subsequent pregnancy of high multiple size.
Adult Embryonal Rhabdomyosarcoma of the Vagina Complicating Pregnancy: A Case Report and Review of the Literature
Authors: Singhal Sandeep , Sharma Sanjiv , De Sudarshan , Kumar Lalit , Chander Subhash , Rath G. K. , Gupta S. Datta 
Published: August 2010

AbstractEmbryonal rhabdomyosarcoma of the vagina in adults per se is uncommon and pregnancy complicated by such tumors is extremely rare. We wish to report one case of vaginal embryonal rhabdomyosarcoma, diagnosed at the age of 23 years who was carrying at the time of initial presentation. The problem of management of rhabdomyosarcoma in adults, particularly when they are associated with pregnancy is discussed. We advocate the use of multiagent chemotherapy and pelvic radiotherapy in its overall management.
Chemotherapeutic Approach to Uterine Papillary Serous Carcinoma
Authors: Hamaguchi Kinya , Komai Kan , Sakihama Hideki , Okura Naofumi , Nagasue Naoki , Nishida Tadashi , Yakushiji Michiaki 
Published: August 2010

AbstractUterine papillary serous carcinoma (UPSC) is a recently recognized histologic variant of endometrial carcinoma with an aggressive clinical course. This study reviews 7 patients with the diagnosis of UPSC treated at the National Kokura Hospital between 1987 and 1989. The mean age was 60 years. Clinically, 4 patients presented as Stage I, one as Stage II, one as Stage III, and one as Stage IV. Surgery upstaged 28.7% (2/7) of these patients. All 7 patients underwent a staging laparotomy followed by chemotherapy. Deep myometrial invasion was found in 5/7 (72%) of the specimens. Four of these 5 specimens demonstrated up to the uterine serosa. Lymph nodal involvement was observed in 1/4 (25%) of the specimens. Furthermore, positive peritoneal washings were obtained in 4/7 (57%) of the specimens. All patients received an adjuvant combination chemotherapy with cisplatin 50 mg/m2 on day 1, adriamycin 50 mg/m2 on day 1, and ifosfamide 1.0 g/m2 on day 1 to day 5 (PAI). Recurrence and relapse of the disease developed in the 2 patients within 6 months. Two patients had a negative second look operation with no evidence of disease (NED) at 18 months after the initial treatment. Serial determination of the serum CA125 was seen to have great value in monitoring treatment in 4 patients. However, additional accural and follow‐up are needed to determine whether or not PAI therapy has an impact on this disease.
Immunohistochemical Localization of CA130 in Fetal Tissues, and in Normal and Neoplastic Tissues of the Female Genital Tract
Authors: Nanbu Yoshihiko , Fujii Shingo , Konishi Ikuo , Nonogaki Hirofumi , Sagawa Norimasa , Kobayashi Fuminori , Mori Takahide , Saga Tsuneo , Endo Keigo 
Published: August 2010

AbstractA murine monoclonal antibody, 130‐22, produced against a human lung adenocarcinoma cell line (PC‐9) has been suggested as recognizing an antigenic determinant (CA130) which is different from an epitope recognized by OC125 on CA125 glycoprotein molecules. The immunohistochemical reactivity with the 130–22 antibody (anti‐CA130) was examined in human fetal tissues, and normal and neoplastic tissues of female genital tracts, and compared to those using OC125.Among the fetal tissues, the amnion and the cells of coelomic epithelium and mullerian‐derived epithelia reacted with anti‐CA130. In normal adult tissues, cervical and endometrial gland cells, tubal epithelial cells, and ovarian surface cells reacted with anti‐CA130. In addition, predecidual cells in the late secretory endometrium and decidual cells during gestation were positive. Among the neoplastic tissues, tubal and endometrial adenocarcinomas and epithelial ovarian tumors were positive for anti‐CA130. There were no differences in the respective specimens between the immunohistochemical localization of anti‐CA130 and of OC125.Therefore, anti‐CA130 is considered to be useful in the immunohistochemical detection of CA125 glycoprotein molecules as well as OC125.
Vaginal Adenosis without Exposure to Diethylstilbesterol: A Case Report
Authors: Pillai Nimish V. , Thye Koh Eng , Kumar Pratap 
Published: August 2010

AbstractVaginal adenosis is an unusual condition seen more in females with diethylstilbesterol (DES) exposure in utero, vaginal adenosis in absense of DES exposure is unusual. A case of vaginal adenosis is presented and the literature is reviewed.