bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uptake of Hepatitis B Vaccination among Female Sex Workers in Kampala, Uganda
Authors: Nakiggala Joana , Lwenge Mathias , Nakalembe Doreen , Tamale Bridget Nagawa , Nalugya Aisha , Galiwango Jovan , Wejuli Junior Mike , Tebandeke Kenneth , Isunju John Bosco , Mugambe Richard K , Ssekamatte Tonny 
Published: May 2024

Abstract

Background
Hepatitis B is a significant health problem worldwide, particularly among high-risk groups such as female sex workers (FSWs). In Uganda, it is highly recommended that FSWs receive the hepatitis B vaccine. However, there is limited evidence of the level of uptake of the vaccine and associated factors among FSWs in Uganda. This study aimed to determine the factors associated with the uptake of hepatitis B vaccination among FSWs in Kampala, Uganda.
Methods
A cross-sectional study design among 400 female sex workers enrolled using multistage sampling techniques was conducted. Data were collected using a digitized semi-structured questionnaire and analyzed using SPSS version 22. Descriptive statistics such as means and standard deviations were used to present continuous data while frequency and portions were used to present categorical data. A “modified” Poisson regression analysis was conducted to establish the relationship between predictor variables and uptake of hepatitis B vaccination.
Results
A total of 400 respondents (98.5% response rate) were interviewed. Close to half, 49.8% (199/400) of the respondents had ever heard about hepatitis B, and 16.5% had received at least a hepatitis B vaccine dose. The individual factors associated were spending more than 4 years in sex work (APR: 1.06, 95%CI: 1.01–1.12, p = 0.010), being screened for hepatitis B (APR: 1.49, 95%CI: 1.38–1.61, p < 0.001), and those whose job (sex work) allowed them to get time to seek HBV services, (APR: 1.13, 95%CI: 1.04–1.22, p = 0.002). The health system were having hepatitis B outreaches in the place of residence (APR: 1.17, 95%CI: 1.03–1.33, p = 0.010) and ever receiving information related to hepatitis B from peers (APR: 1.07, 95%CI: 1.05–1.31, p = 0.004).
Conclusion
The study revealed a low hepatitis B vaccination uptake among FSWs, with less than a tenth having completed the recommended three vaccine doses. These results suggest the need for targeted health initiatives that leverage peer-driven system and enhance outreach programs to improve hepatitis B vaccine uptake and overall health outcomes within this population.
Adaptive Neural Self-Triggered Bipartite Consensus Control for Nonlinear Fractional-Order Multi-Agent Systems With Actuator Fault
Authors: Wei Fansen , Niu Ben , Zong Guangdeng , Zhao Xudong 
Published: May 2024

Abstract

In this paper, the bipartite consensus tracking control problem is investigated for a class of nonlinear fractional-order multi-agent systems (FOMASs) with unknown dynamics, actuator faults, and input nonlinearities. Based on the adaptive backstepping technique, an adaptive bipartite consensus tracking control framework is constructed for FOMASs, where both cooperative and competitive relationships among agents are implemented. Furthermore, a fault compensation mechanism is proposed to relax the restriction on the number of actuators that can fail, and to allow the existence of different types of input nonlinearities for each actuator. In addition, an improved adaptive selftriggered control mechanism that can be dynamically adjusted depending on the bipartite consensus error is extended to FOMASs to save network resources and enhance system performance. Then, by means of the fractional-order Lyapunov stability criterion, it is theoretically proved that the proposed control scheme ensures that all signals of the closed-loop systems are bounded and drives the bipartite consensus error into a desired neighborhood of the origin. Finally, simulation results are provided to confirm the effectiveness of the proposed control scheme.
Diversity of endophytic bacteria with antimicrobial potential isolated from marine macroalgae from Yacila and Cangrejos beaches, Piura-Peru
Authors: Portalatino Edwin Jorge Vega , Cuentas Miriam Marleni Rosales , Angeles Carmen Tamariz , Gonzales Percy Olivera , Espinoza Luis Alfredo Espinoza , Quispe Luz Arelis Moreno , Zevallos Jube Ciro Portalatino 
Published: May 2024

Abstract

Endophytic bacteria from marine macroalgae (EBMM) have aroused interest for their antimicrobial activity, becoming a new source of bioactive compounds for the control of pathogenic bacteria, yeasts and fungi. EBMMs were isolated from Caulerpa sp., Ulva sp., Ahnfeltiopsis sp. and Chondracantus chamissoi collected from Yacila and Cangrejo beach (Piura, Peru). Antimicrobial assays against pathogenic bacteria were evaluated by the cross method, over plate test (OpT) and volatile organic compound test (VOCt). Bacteria with the best antibacterial potential were molecularly characterized, evaluated for antifungal activity and the presence of Iturin, Fengycin and Surfactin genes. Forty-six EBMM were isolated, most of them from the phylum Rhodophyta group and coming from Yacila. In the crossmatch evaluation, 10 EBMMs were found to inhibit gram-positive pathogenic bacteria (Enterococcus faecalis, Staphylococcus epidermidis, Staphylococcus aureus and Listeria monocytogenes) and 12 gram-negative bacteria (Escherichia coli and Salmonella enteric sv typhimurium). These activities were confirmed by OpT and VOCt. The selected strains were identified as 4 Bacillus sp., 2 Kluyvera ascorbata, 1 Pantoea agglomerans, 1 Leclercia adecarboxylata and 1 Enterobacter sp. The strains, P. agglomerans YAFL6, Enterobacter sp. YAFL1, Bacillus sp. YCFR6 and Bacillus sp. YUFE8 showed high antifungal activity on Candida albicans, Candida tropicalis, Colletotrichium sp., Fusarium sp., Fusarium oxysporum and Alternaria sp. In addition, K. ascorbata YAFE21 and Bacillus sp. YCFE4 showed the presence of Iturin and Fengycin genes. The results obtained show the potential of the selected marine bacteria for future applications in the production of antibacterial metabolites and antifungal control.
Trans articular cartilage retrograde intramedullary pinning surgery for humeral transcondylar fractures effective for postoperative elbow joint contracture prevention
Authors: Taguchi Hiroyuki , Moriya Kozo 
Published: May 2024

Abstract

As a treatment for humeral transcondylar fractures, conservative therapy is prone to pseudoarthroplas. Various surgeries are performed, but plate fixation is highly invasive to soft tissues and prone to contractures of the elbow joint, while percutaneous pinning is weak in fixation and tends to damage the ulnar nerve.
Our "trans articular cartilage retrograde intramedullary pinning surgery" is an excellent surgical method that is less invasive to soft tissues, has accurate reduction, has strong fixation, and does not damage the ulnar nerve.
As a result, reliable bone fusion and a range of motion of the elbow joint that is effective in daily life can be realized.
Where Does the Heme Go? Unraveling Heme and Porphyrin Metabolism in Healthy and Oncogenic Human Livers
Authors: Adapa Swamy , meshram Pravin , Sami Abudas , Jiang Rays 
Published: May 2024

Abstract

The liver, a pivotal organ in human metabolism, serves as a primary site for heme biosynthesis, critical for detoxification and drug metabolism. Maintaining precise control over heme production is paramount in healthy livers to meet high metabolic demands while averting potential toxicity from intermediate metabolites, notably protoporphyrin IX. Intriguingly, our recent research uncovers a disrupted heme biosynthesis process termed 'Porphyrin Overdrive' in cancers, fostering the accumulation of heme intermediates, potentially bolstering tumor survival. Here, we investigate heme and porphyrin metabolism in both healthy and oncogenic human livers, utilizing primary human liver transcriptomics and single-cell RNA sequencing (scRNAseq). Our investigations unveil robust gene expression patterns in heme biosynthesis in healthy livers, supporting electron transport chain (ETC) and cytochrome P450 function, devoid of intermediate accumulation. Conversely, liver cancers exhibit impaired heme biosynthesis and massive downregulation of cytochrome P450 expression. Notably, despite diminished drug metabolism, heme supply to the ETC remains largely unaltered or even elevated with cancer progression, suggesting a metabolic priority shift. Liver cancers selectively accumulate intermediates, absent in normal tissues, implicating their role in disease advancement as inferred by expression. Furthermore, our findings establish a link between diminished drug metabolism, augmented ETC function, porphyrin accumulation, and inferior overall survival in aggressive cancers, indicating potential targets for clinical therapy development.
Integrated positron emission particle tracking (PEPT) and x-ray computed tomography (CT) imaging of flow phenomena in twisted tape swirl flow
Authors: Wiggins Cody S. , Cabral Arturo , Mafi Adam , Houston Jerel , Carasik Lane B. 
Published: May 2024

Abstract

A combined positron emission particle tracking (PEPT) and x-ray computed tomography (CT) technique is presented, and its utility is demonstrated through investigation of flow in a pipe with twisted tape swirl insert with varying flow conditions (diameter-based Reynolds numbers 16,300 to 63,300). A description of this technique is given, as well as data handling practices used to relate geometric information captured by CT to fluid flow data gathered via PEPT. It is found that the CT component is readily capable of capturing the stainless steel insert geometry in this present system, but the use of combined plastic and metal materials leads to artifacts in imaging of the plastic surface. Nonetheless, CT data are related to PEPT flow measurements, and average velocity fields are calculated via a pseudo-framing and interpolation scheme and used to visualize and interrogate key flow phenomena within the system. Radial velocity profiles of the mean flow characteristics are seen to collapse to a nearly common form across all flow conditions considered. Helical vortices are seen propagating through the flow field, generated by bypass flow around the gap between the insert and pipe wall, with additional coherent secondary flow structures seen in the higher Reynolds number cases. These findings enhance the understanding of the mixing mechanisms in these swirl flows and encourage the continued development of PEPT-CT methodologies for 3D flow measurements in optically inaccessible systems.
Nutritional Status of Children in Bangladesh : Changes and Challenges for Development
Authors: Ali Md Idris 
Published: May 2024

Abstract

Bangladesh have made a remarkable change of nutritional status of children over the decade despite of poverty. Stunting, underweight and wasting in children under age five years were gradually reduced from 1990s to 2020s and improved children health status over the year. This paper explains the trends of nutritional status of children in Bangladesh over the decades by different age groups of children, causes of changing nutrition status, and future challenges for development in Bangladesh. The national level survey (BDHS), national plan and policy paper, and existing literature are used for the study. Changing nutritional status of children aged under five years from high level stunting, underweight and wasting to gradual improved is remarkable for Bangladesh. Aged between 12-23 months children are more vulnerable for being stunt, waste and underweight than other ages. There have a rural-urban, wealth status and mother’s education affect the nutritional status of children. Income and poverty reduction, improve water and sanitation, maternal and child health, food and dietary practice and many policies and programs are the main causes for changing nutrition level of children in Bangladesh. But there are many challenges for future development for children nutrition status in Bangladesh like child and under five mortality, child malnutrition, double burden of malnutrition, and gaps of policies and programs in Bangladesh to achieve national plan, SDGs target and achieving demographic dividend with healthy population.
Analysis of satisfaction of stroke patients with medical rehabilitation using multimodal correction technology
Authors: Kostenko E. V. , Pogonchenkova I. V. , Petrova L. V. , Kashezhev A. G. , Kaverina E. V. , Filippov M. S. , Kozlova K. A. 
Published: May 2024

Introduction. The quality of medical care is determined not only by the dynamics of functional recovery, but also depends on the patient satisfaction index, which is highly informative and should be used in in its assessment. Aim. To study and analyze the level of satisfaction of patients after ischemic stroke (IS) with the quality of MR services provided using the technology of multimodal correction of motor and cognitive disorders in the early recovery period.Materials and methods. An anonymous survey was conducted of 186 patients with IS who underwent rehabilitation in inpatient and outpatient settings at the Moscow Research and Practice Center for Medical Rehabilitation, Restorative and Sports Medicine named after S.I. Spasokukotsky, using a specially designed questionnaire including 20 questions, as well as an analysis of medical and social factors affecting MR satisfaction.Results. The majority of respondents (89.8%) were generally satisfied the results of MR, while more than half (65%) plan to undergo further MR using this technology. According to respondents, the favorable result of MR is influenced by the presence of relatives next to the patient (76.0%) and in 14.0% by the presence of a nurse, the availability of special training in rehabilitation of doctors and nursing staff (38%), awareness of the impact of rehabilitation measures for their existing functional disorders (94%). Almost three quarters of respondents noted that the individual regime of the rehabilitation program has the greatest impact on the successful outcome of rehabilitation (72.0%). At the same time, two thirds of specialists consider an important aspect to be the comprehensive work of all specialists engaged in MR (64.0%). The medical staff was highly appreciated by 44.1%, 34.9% and 21.0% highly. 36% of patients are highly satisfied with the results of MR, 42% are quite satisfied, and 16% of respondents gave an assessment of “average, normal”. Among the main reasons for dissatisfaction with MR are remoteness of residence from a medical organization, absence of relatives during the course of MR, the long duration of the MR course, lack of awareness information about the impact of multimodal correction technology on the restoration of impaired functions.Conclusions. Based on the analysis of the overall patient satisfaction with the medical care provided by MR for stroke patients, using the technology of multimodal correction of motor and cognitive impairments, directions for improving the quality of medical services were identified.
SARS-CoV-2 wastewater surveillance at two university campuses: lessons learned and insights on intervention strategies for public health guidance
Authors: Porter Alexis M. , Hart John J. , Rediske Richard R. , Szlag David C. 
Published: May 2024

ABSTRACT

Wastewater surveillance has been a tool for public health officials throughout the COVID-19 pandemic. Universities established pandemic response committees to facilitate safe learning for students, faculty, and staff. These committees met to analyze both wastewater and clinical data to propose mitigation strategies to limit the spread of COVID-19. This paper reviews the initial efforts of utilizing campus data inclusive of wastewater surveillance for SARS-CoV-2 RNA concentrations, clinical case data from university response teams, and mitigation strategies from Grand Valley State University in West Michigan (population 21,648 students) and Oakland University in East Michigan (population 18,552 students) from November 2020 to April 2022. Wastewater positivity rates for both universities ranged from 32.8 to 46.8%. Peak viral signals for both universities directly corresponded to variant points of entry within the campus populations from 2021 to 2022. It was found that the organization of clinical case data and variability of wastewater testing data were large barriers for both universities to effectively understand disease dynamics within the university population. We review the initial efforts of onboarding wastewater surveillance and provide direction for structuring ongoing surveillance workflows and future epidemic response strategies based on those that led to reduced viral signals in campus wastewater.
The banana tree circle as a nature-based solution for sustainable greywater management: A new design model
Authors: Rezende Mudadu Silva Juliano , Carraro Borges Alisson , Lüthi Christoph , Spuhler Dorothee , Fernandes Raphael Bragança Alves 
Published: May 2024

ABSTRACT

The banana tree circle (BTC) is a low-cost system for local greywater management, using a natural treatment and disposal process, providing additional resource recovery benefits. However, there are no standard design criteria for BTC that would allow for quality control of its efficiency and sustainability, and little is currently known about the full-scale performance of BTC. Based on the scoping literature review of 31 documents in the scientific database and eight documents from grey literature, a standard design model was proposed for the BTC technology based on the concept of water balance, greywater flows, rain, infiltration, and evapotranspiration. The first two steps of the BTC design were determining the areas required for infiltration and evapotranspiration. A cylindrical form trench, the soil percolation rate, and the hydraulic loading rate were considered for the infiltration area. The banana trees’ evapotranspiration rate was taken into consideration for the evapotranspiration area. The proposed model was applied in a case study where we used a trench with 0.8 m depth and 1.5 m diameter. This study proposes a standard design criterion for the BTC based on environmental factors, and the scoping of the literature provides the basis for future studies to evaluate its environmental sustainability.
Migration of various ions based on pH shifts triggered by the application of sediment microbial fuel cells
Authors: Matsuki Masaya , Hirakawa Shusaku 
Published: May 2024

ABSTRACT

Sediment microbial fuel cells (SMFCs) represent a technology that can enhance sediment quality through processes such as nutrient suppression while simultaneously generating electricity from microorganisms. Despite its importance in elucidating the principles of nutrient suppression, the complex behavior of various ions within this context has been rarely explored. Herein, we applied an SMFC and systematically evaluated alterations in ion concentrations in interstitial and overlying waters. The SMFC deployment substantially decreased Na+ concentrations and increased Cl− levels in the interstitial water. This intriguing phenomenon was attributed to reactions driven by the electrodes. These reactions induced remarkable shifts in pH. Consequently, this pH shift triggered the leaching of heavy metals, particularly Fe, and decreased HCO3− concentrations within the interstitial water, thereby inducing the migration of other ions, including Na+ and Cl−, as compensation. Moreover, the PO43− concentration in interstitial water showed an increasing trend upon SMFC application, which contradicts the results of several previous reports. This increase was primarily attributed to the release of PO43−caused by the leaching of Fe salts, which was triggered by the pH shift. These findings provide new insights into sediment improvement research through SMFCs, enhancing our understanding of the fundamental principles and broadening the potential applications of this technology.
Synthesis, In Silico Prediction, and In Vitro Evaluation of Anti-tumor Activities of Novel 4'-Hydroxybiphenyl-4-carboxylic Acid Derivatives as EGFR Allosteric Site Inhibitors
Authors: Shihab Wurood A. , Kubba Ammar A. Razzak , Tahtamouni Lubna H. , Saleh Khaled M. , AlSakhen Mai F. , Kanaan Sana I. , Saleh Abdulrahman M. , Yasin Salem R. 
Published: May 2024

Introduction:
Allosteric inhibition of EGFR tyrosine kinase (TK) is currently
among the most attractive approaches for designing and developing anti-cancer drugs to
avoid chemoresistance exhibited by clinically approved ATP-competitive inhibitors.
The current work aimed to synthesize new biphenyl-containing derivatives that were predicted
to act as EGFR TK allosteric site inhibitors based on molecular docking studies.

Methods:
A new series of 4'-hydroxybiphenyl-4-carboxylic acid derivatives, including
hydrazine-1-carbothioamide (S3-S6) and 1,2,4-triazole (S7-S10) derivatives, were synthesized
and characterized using IR, 1HNMR, 13CNMR, and HR-mass spectroscopy.

Results:
Compound S4 had a relatively high pharmacophore-fit score, indicating that it
may have biological activity similar to the EGFR allosteric inhibitor reference, and it
scored a relatively low ΔG against EGFR TK allosteric site, indicating a high likelihood
of drug-receptor complex formation. Compound S4 was cytotoxic to the three cancer
cell lines tested, particularly HCT-116 colorectal cancer cells, with an IC50 value comparable
to Erlotinib. Compound S4 induced the intrinsic apoptotic pathway in HCT-116
cells by arresting them in the G2/M phase. All of the new derivatives, including S4, met
the in silico requirements for EGFR allosteric inhibitory activity.

Conclusion:
Compound S4 is a promising EGFR tyrosine kinase allosteric inhibitor that
warrants further research.
Analysis of the Value of Character Education in the Surakarta Style Javanese Bridal Paes and Its Relevance for Javanese Language Learning in Elementary Schools
Authors: Rahadini Astiana Ajeng , Wijayanti Kenfitria Diah , Veronika Prima , Fitriana Tya Resta , Sulaksono Djoko , Lestari Winda Dwi , Waluyo Budi 
Published: May 2024

This research was a qualitative descriptive research using a semiotic approach. This research aims to analyze the value of character education contained in the symbols in the Surakarta style Javanese bridal paes and its relevance as the Javanese language learning material for elementary school level. The symbols in Javanese bridal paes are a medium for transforming noble values containing Javanese cultural teachings for bridal couples in particular and Javanese society in general, especially the younger generation. This is closely related to character development based on local genius. Therefore, this research tries to describe the symbols in Surakarta style Javanese bridal paes as a manifestation of character education values. Each part in Javanese bridal paes is a representation of local wisdom intended to be a medium for educating noble character. The main data collection techniques are direct observation, interviews, documentation of Javanese Surakarta style brides which are strengthened by documentation analysis. For the validity of the data, credibility techniques are used which are carried out by: 1) diligent observation, 2) triangulation of methods and sources, 3) peer discussion, 4) adequacy of references. The data validity technique uses theory triangulation and source triangulation. The data analysis technique in this research uses Charles Sanders Pierce's semiotic analysis technique. The research results show that each part of the Surakarta style Javanese bridal paes is a symbol that contains noble Javanese cultural values which can be a guide for the bridal couple and relevan for Javanese Language Learning in Elementary Schools.