bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of different extraction methods on the chemical composition, antioxidant activity and flavor of bayberry (Myrica rubra Sieb. et Zucc.) kernel oil
Authors: Yang Yunyun , Huang Zhaoxian , Xie Dan , Luo Jingru , Wang Taiwei , Xie Liangliang , Zhu Xiping , Zhuang Qibin , Guo Yubao , Zhu Xiuling , Jin Jun , Liang Li 
Published: February 2025

AbstractBayberry (Myrica rubra Sieb. et Zucc.) kernel is a by‐products of bayberry processing and are rich in oil. This study investigates the effects of different processing methods on bayberry kernel oil (BKO) yield, including cold pressing (CP), direct solvent (n‐hexane) extraction, ultrasound‐assisted n‐hexane extraction (UAE), steam explosion pretreatment to assist n‐hexane extraction, aqueous enzyme extraction, and supercritical fluid extraction (SFE). The acid value, peroxide value, fatty acid composition, bioactive components content, and the antioxidant activity of the extracted BKO with six methods were compared. The results showed that the oil yield of bayberry kernel extracted by different methods was between 30.95% and 49.49%, and the oil yield of UAE was the highest. BKO samples extracted by different methods had lower acid value (0.39–0.59 mg KOH/g) and peroxide value (3.97–5.84 meq O2/kg), and were rich in unsaturated fatty acids (>85%), mainly including oleic (46.9%–47.9%) and linoleics (37.0%–39.5%). Meanwhile, BKO contained phytosterols (384.67–597.14 mg/100 g) and tocopherols (632.09–1227.62 µg/100 g), which was positively correlated with antioxidant activity. The volatile organic compounds (VOCs) of BKO varied on extraction methods. BKO extracted by CP and SFE showed more VOCs (25 in CP‐BKO, 26 in SFE‐BKO). The representative VOCs in BKO are alcohols and esters. The results provide references for further processing of BKO.
Macroporous adsorbent resin debittering of Huang long bing (HLB)‐affected orange juice and its impacts on consumer sensory acceptance
Authors: Washington Taylor L. , Briceno Fabiana V. , Sims Charles A. , Nau Katlyn , Yagiz Yavuz , Gu Liwei 
Published: February 2025

AbstractHuang long bing (HLB) infection of oranges induces the biosynthesis and accumulation of bitter limonoids. The objective of this study was to debitter HLB‐affected orange juice while preserving the tasteless and health‐promoting limonoid glucoside and flavanones using resin adsorption. Three resins (FPX66, PAD900, and XAD16N) were found to have higher adsorption and desorption capacity for limonin among seven selected resins. Adsorption of limonoids rapidly increased in the first 2 h of kinetic tests, while slower adsorption kinetics were observed for flavanones. Limonin isothermal adsorption fit best with the Langmuir model, suggesting a physical, monolayer process. Dynamic adsorption showed that a fixed‐bed column packed with PAD900 was able to debitter 200 bed volumes of orange juice before limonin reached its taste threshold of 4.7 µg/mL in the eluent. The resin was regenerated by eluting the column with four bed volumes of alcohol or 4% NaOH to remove adsorbed compounds from the resin. Resin adsorption reduced limonin content in orange juice from 5.85 to 1.34 µg/mL but also decreased tasteless compounds by at least 40%. A consumer sensory test gave the debittered juice a higher overall liking and preference over untreated juice. This study showed that resin adsorption is an effective approach to reduce the bitterness of orange juice affected by HLB.
Association of Poor Sleep Quality With Adverse Outcomes in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta‐Analysis
Authors: Xu Tian Yun , Zhang Yue , Zhao Shu Liang 
Published: February 2025

ABSTRACTObjectivesInflammatory bowel disease (IBD) is a group of chronic diseases with adverse events such as disease flare, progression, drug escalation, hospitalization, and surgery. Meanwhile, patients with IBD often have sleep disorders. We performed this systematic review and meta‐analysis aiming to investigate the relationship between sleep quality of patients with IBD and their prognosis.MethodsMEDLINE and Web of Science Core Collection databases were searched for articles published up to November 2024. We pooled the hazard ratio (HR) and odds ratio (OR) with the corresponding 95% confidence interval (CI) for adverse outcome events during the follow‐up period in patients with poor sleep quality at baseline compared with those with normal sleep quality.ResultsFive studies were included with a total of 2333 patients with IBD. Poor sleep quality in patients with IBD was significantly correlated with the occurrence of adverse outcome events at follow‐up (OR 1.63, 95% CI 1.14–2.33). Patients with Crohn's disease (CD) with poor sleep quality had a significantly higher risk of adverse outcome events at follow‐up (OR 1.58, 95% CI 1.26–1.99), whereas those with ulcerative colitis (UC) did not (OR 1.10, 95% CI 0.76–1.60).ConclusionEarly identification of poor sleep quality in patients with IBD, especially CD, has a predictive effect on their prognosis.
Glucokinase Regulatory Protein as a Putative Target for Gestational Diabetes Mellitus and Related Complications: Evidence From the Mendelian Randomization Study
Authors: Mao Weian , Wang Guiquan , Wang Xiao , Shen Yan , Yuan Shuai , Wang Lin , Yang Haiyan , Li Yan , Chen Kai , Liu Jun , Dong Xi , Zhao Yue , Mu Liangshan 
Published: February 2025

ABSTRACTBackgroundGestational diabetes mellitus (GDM) is one of the most common complications of pregnancy and is highly associated with adverse perinatal outcomes and long‐term health problems for the mother and offspring. However, there are respective limitations in the pharmacological strategies for the current treatment of GDM. Glucokinase regulatory protein (GCKR) has been associated with GDM in observational studies and animal experiments and thus represents a potential drug target of interest for investigation.MethodsWe applied two‐sample Mendelian randomization (MR) and colocalization analysis using summary‐level data from genome‐wide association studies of GCKR and GDM. Two‐step MR was used to explore the mediating effects of several metabolic factors on the association. We also applied MR to explore the associations of GCKR levels with GDM‐related outcomes. Finally, we performed a phenome‐wide association study (PheWAS) to query the potential effects of altered GCKR levels across multiple health categories.ResultsWe found a significant association between elevated GCKR levels and GDM (OR = 3.466, 95% CI = 2.401–5.002, p = 3.16 × 10−11), also supported by the colocalization analysis ([Pcoloc] = 0.997). The estimates were replicated in an independent study (OR = 2.640, 95% CI = 1.983–3.513, p = 2.84 × 10−11, Pcoloc = 0.983). Elevated GCKR levels were also associated with higher risk of type 2 diabetes (OR = 2.183, 95% CI = 1.846–2.581, p = 6.53 × 10−20). Two‐step MR suggested that fasting glucose, fasting insulin, and triglycerides partly mediated the causal relationship. PheWAS found that targeting GCKR may improve renal function and glucose homeostasis but cause dyslipidemia and uric acid abnormalities.ConclusionsThis study provided novel evidence that circulating GCKR levels are causally implicated in GDM and related complications, suggesting that it may be a promising target for treatment.
Prevalence of Human Leukocyte Antigen (HLA)‐B*58:01 and Allopurinol‐Induced Adverse Reactions in Filipino Patients in Hawai'i: Implications for Genotyping
Authors: Terashima Rika , Medina Alejandro Jude P. , Del Mundo Hans Jesper F. , Briones Ryan Sean S. , Aquino Joseph Arman B. , Quiminiano Ellaine M. , Sin Yuh Miin , Bautista Rhea A. , Sonido Charlie Y. , Yamada Seiji 
Published: February 2025

ABSTRACTIntroductionAllopurinol, a first‐line treatment for gout and hyperuricemia, is associated with severe cutaneous adverse reactions (SCAR) in individuals carrying the HLA‐B*58:01 allele. Genotyping is conditionally recommended in Han Chinese, Korean, and Thai populations with an allele prevalence of 7.4%, and in African Americans at 3.8%. The prevalence in Filipino patients has not been studied. We investigate the prevalence of HLA‐B*58:01 among Filipino patients in Hawai'i and evaluate the incidence of allopurinol‐induced adverse reactions following genotyping.MethodsWe conducted a retrospective chart review of 312 patients who underwent HLA‐B*58:01 genotyping at a primary care clinic in Hawai'i between November 2021 and July 2024. After excluding patients with missing ethnicity data, non‐Filipino ethnicity, or prior allopurinol use, 237 Filipino patients were included in the analysis. The prevalence of the HLA‐B*58:01 allele and the incidence of allopurinol‐induced adverse reactions were calculated.ResultsAmong the 237 Filipino patients, 17 (7.2%) were HLA‐B*58:01 positive. A total of 97 patients were started on allopurinol after genotyping and 1 (1.0%) developed mild cutaneous reactions, 0 (0%) developed SCAR, and 2 (2.1%) experienced gastrointestinal symptoms (nausea and diarrhea).ConclusionThe high prevalence of HLA‐B*58:01 allele among Filipino patients in Hawai'i suggests that genotyping may be considered before initiating allopurinol treatment. Given no instances of SCAR were observed in patients who were administered allopurinol after undergoing HLA‐B*58:01 genotyping, genotyping may play a crucial role in reducing the risk of allopurinol‐induced SCAR in this population. Further studies with larger cohorts are suggested to confirm our findings and assess broader clinical utility of genotyping.
Work–family–self‐care and day drinking among women during the COVID‐19 pandemic
Authors: Stewart Susan D. 
Published: February 2025

AbstractBackgroundThe term “day drinking” is used colloquially to refer to drinking alcohol during daytime hours and has become part of the vernacular surrounding alcohol use. Anecdotal evidence is suggestive of increased day drinking among women during the COVID‐19 pandemic, but empirical studies are few. This study assessed changes in the time of day women consumed alcoholic beverages during the pandemic and investigated whether their difficulty balancing work, family, and self‐care was associated with the initiation of daytime drinking.MethodsIn June of 2020, 546 women age 25 and older completed an online survey regarding their drinking behaviors pre‐ and post‐COVID‐19, perceived stress, COVID‐19 anxiety, and degree of difficulty managing work, family, and personal care. Multivariate logistic regression models assessed associations between variables, controlling for women's sociodemographic characteristics.ResultsWomen shifted to drinking earlier in the day with the onset of the COVID‐19 pandemic, with a specific increase in daytime drinking. Difficulty managing work, family, and self‐care was associated with significantly greater odds of initiating day drinking, but perceived stress and COVID‐19 anxiety were not.ConclusionsAlcohol consumption is harmful to women's health. In addition to work and family roles, researchers should continue to explore how self‐care affects women's alcohol use, and specifically temporal patterns, especially in times of crisis.
Is there really a dictator's dilemma? Information and repression in autocracy
Authors: Gehlbach Scott , Luo Zhaotian , Shirikov Anton , Vorobyev Dmitriy 
Published: February 2025

AbstractIn his seminal work on the political economy of dictatorship, Ronald Wintrobe posited the existence of a “dictator's dilemma,” in which repression leaves an autocrat less secure by reducing information about discontent. We explore the nature and resolution of this dilemma with a formalization that builds on recent work in the political economy of nondemocracy. When the regime is sufficiently repressive, and the dictator's popularity correspondingly unclear to opposition as well as autocrat, the ruler faces two unattractive options: He can mobilize the repressive apparatus, even though there may be no threat to his rule, or he can refrain from mobilizing, even though the danger may be real. Semicompetitive elections can ease the dilemma through the controlled revelation of discontent. Paradoxically, the manipulation of information through such non‐repressive means can allow for more rather than less repression.
Religious authority in the urban mosque
Authors: Chaplin Chris 
Published: February 2025

AbstractIn Eastern Indonesia, young male Islamic activists articulate a notion of religious authority that reorients community life toward neighborhood mosques. By providing local communities with Qur'anic classes and religious services, these activists—affiliated with Indonesia's largest Salafi organization—have created a network of spaces in which they promote new religious lifeworlds grounded in the substantive relationships they build across these neighborhoods. But “being present” in the mosque pertains to more than physically existing in a space; it speaks to the processes and strategies through which activists draw from local Islamic histories, legal codes, nationalist tropes, and moral anxieties to make and remake an ethical image of Islamic belonging. Such practices reveal the relational, spatial, but also contingent nature of contemporary religious authority. Moreover, they refocus anthropological analysis onto the experiential and collective moments through which new moral worlds emerge.
Can the choice of artificial tears harm patients? A narrative review with an overview of the Nordic market
Authors: Mikha K. N. , Rasmussen C. E. Ø. , Ahrensberg S. N. G. , Freiberg J. , Wozniak R. A. , Alnoor U. M. K. , Fineide F. , Utheim T. P. , Heegaard S. , Kolko M. 
Published: February 2025

AbstractPurposeTo provide an overview of artificial tears marketed in the following Nordic countries: Denmark, Finland, Norway, Iceland and Sweden. Furthermore, this review aimed to highlight the different preservatives and other constituents found in artificial tears in the Nordic market, focussing on adverse effects.MethodsArtificial tears appearing in online pharmacies in Denmark, Norway, Sweden, Finland and Iceland were included, and tables listing their components were created. Based on the preservatives and other constituents found in the artificial tears on the Nordic market, a literature search was conducted to investigate differences and potential adverse effects. This was achieved using PubMed with MeSH and free text search terms. Included articles were (i) studies performed on humans in vivo or in vitro human models, (ii) published between 2000 and 2023 and (iii) focussing on adverse effects, preservatives, toxicity, other constituents and preservative‐free artificial tears.ResultsA total of 88 artificial tears were found on the Nordic market. Approximately 32% (28 out of 88) of the artificial tears contain preservatives. Eleven of these are preserved with benzalkonium chloride (BAK) or cetrimide. After a thorough literature search, evidence has been found for the toxic effects of BAK and cetrimide. There is no evidence of toxic effects of lubricants, osmoprotectants and lipids.ConclusionsThe findings of this review highlight the paradoxical fact that many treatments for ocular surface diseases contain toxic preservatives that may lead to worsening of the condition. In particular, long‐time toxic effects of BAK may contribute to disease progression.
Risk of Hepatocellular Cancer in U.S. Patients With Compensated Cirrhosis Treated With Direct‐Acting Antivirals Versus Interferon
Authors: El‐Serag Hashem B. , Duong Hao , Luster Michelle , Kanwal Fasiha , Hill Deanna D. , Burroughs Margaret , Hernandez Candido , Haber Barbara A. , Larsen Lois M. , Marcinak John F. , Wegrzyn Lani R. , Kramer Jennifer R. 
Published: February 2025

ABSTRACTBackgroundFew studies have examined the risk of de novo hepatocellular carcinoma (HCC) among hepatitis C virus (HCV)–infected patients with cirrhosis who received interferon (IFN)‐free direct‐acting antiviral (DAA) therapy relative to patients who received IFN‐containing therapy or remained untreated.AimsTo estimate the risk of de novo HCC with DAA treatment in cirrhotic HCV patients compared to no anti‐HCV treatment and those treated with IFN‐based therapy.MethodsWe identified patients with chronic HCV infection and compensated cirrhosis in the US Department of Veterans Affairs healthcare system treated with IFN (2005 to 2013) or DAAs (2013 to 2017). We compared the risk of de novo HCC for patients treated with DAAs, IFN‐containing regimens or no treatment after accounting for differences in demographics, alcohol and drug abuse, comorbidities, laboratory values, healthcare utilisation, prior HCV treatment and HCC surveillance.ResultsA total of 53,847 patients contributed to untreated time, 27,147 patients contributed to DAA‐treated time (15,641 contributed to both untreated and DAA‐treated times) and 6809 patients contributed to IFN‐treated time. HCC risk associated with DAA treatment was significantly lower than untreated [adjusted HR: 0.70 (95% CI: 0.65–0.74)]. The risk of HCC was not significantly different for patients treated with DAA compared with those treated with IFN [adjusted HR: 0.98 (95% CI: 0.87–1.10)].ConclusionsThe study shows a reduced risk of de novo HCC among patients with chronic HCV–related compensated cirrhosis who received DAA treatment compared to that of untreated patients. There were no differences in HCC risk between DAA‐treated and IFN‐treated patients.
Linking Up Degrowth in/From the South With Provincialised UPE: Mangrove and Groundwater Conservations in Semarang, Indonesia
Authors: Batubara Bosman , Belland Marie , Kooy Michelle 
Published: February 2025

ABSTRACTThis article brings degrowth into conversation with urbanisation through our analysis of environmental transformations in the coastal Southern city of Semarang, Indonesia. We analyse two collective activisms to build a theoretical dialogue between degrowth and provincialised urban political ecology (UPE). The first activism contests the ongoing development of pro‐growth giant flood infrastructure and is politically rooted in mangrove ecosystem conservation. The second activism conserves groundwater. We identify mangrove and groundwater conservations as spatial practices of degrowth in/from the south. We make connections between the two scholarships and activisms to expand their political and pragmatic possibilities and, therefore, open space for more hopeful alternatives for the city's future.
Evaluating the impact of general practice pharmacist‐led person‐centred medicines reviews on medicines appropriateness and patient‐reported outcome measures
Authors: Kinahan Clare , Kirke Ciara , O'Hagan Leon , Moriarty Frank , Murphy Kevin D. , Sahm Laura J. , O'Mahony Cian , Coyle Emma J. , Byrne Stephen , Dalton Kieran 
Published: February 2025

AbstractAimThe aim of this study was to investigate the impact of pharmacist‐led person‐centred medicines reviews in general practices on medicines appropriateness, polypharmacy indicators (high‐risk prescribing markers), and patient‐reported outcome measures (PROMs).MethodsFour pharmacists conducted person‐centred medicines reviews in ten general practices between January 2021 and December 2022 for patients with hyperpolypharmacy (prescribed ≥10 regular medicines) and/or at high risk of medicines‐related harm. Prescribing recommendations were provided to the general practitioner and followed up with patients and/or healthcare professionals. In this single arm study, pre and post intervention: (1) polypharmacy indicators were documented, and for a sample of patients, the (2) Person‐Centred Medication Appropriateness Index (PC‐MAI) scores and (3) PROMs were gathered.ResultsOf the 1471 included patients, the mean age was 76 years, 88.4% had hyperpolypharmacy, whilst the mean number of medicines was 13.8 pre and 12.3 post review. Of the 1056 polypharmacy indicator occurrences identified, 70.7% were resolved post review. Of the 194 patients with pre‐review and post‐review PC‐MAI scores, 99% had a reduction; the mean reduction was 17.3 (95% confidence interval [CI] 15.8–18.8, P < .0001) per patient and 1.2 (95% CI 1.0–1.3, P < .0001) per medicine. PROMs were collected for 179 patients; 87.7% reported the review helped their medicines understanding, 63.1% their experience of side effects, 36.9% their ability to take medicines correctly, and 30.5% the impact of medicines on their daily activities.ConclusionsGeneral practice pharmacist‐led person‐centred medicines reviews for patients with hyperpolypharmacy and/or at high risk of medicines‐related harm delivered substantial improvements in medicines appropriateness and patient‐reported outcomes, thus providing evidence to support their wider implementation.
Lung tumor organoids migrate as cell clusters containing cancer stem cells under hypoxic condition
Authors: Li Yanjiao , Zou Jiarong , Fang Yanhua , Zuo Jianing , Wang Ruoyu , Liang Shanshan 
Published: February 2025

AbstractBackgroundTumor hypoxia reshapes the microenvironment, driving progression, invasion, metastasis, and therapy resistance. Patient‐derived tumor organoids, formed under three‐dimensional conditions, preserve cellular heterogeneity and nutrient gradients, making them ideal for studying hypoxia‐induced tumor responses. This study examines hypoxia‐induced changes in lung tumor organoids from two patients, focusing on tumor‐associated markers, stem cell markers, and migration capabilities.ResultsOur findings demonstrate that hypoxia distinctively modulates the expression of lung cancer markers thyroid transcription factor‐1, cytokeratin 7, and ΔNP63 variant. Hypoxia also induces the upregulation of stem cell‐associated markers, resulting in an increased proportion of cancer stem cells. Furthermore, hypoxic lung tumor organoids exhibit unique migratory behavior upon reoxygenation, driven by epithelial‐mesenchymal transition and the elevated expression of matrix metalloproteinases 7 and matrix metalloproteinases 9, indicating their enhanced invasive potential.ConclusionsThese findings highlight the value of lung tumor organoids as models for studying hypoxia's complex role in lung cancer. Hypoxia significantly modulates lung tumor organoids growth, stemness, and migratory behavior, providing critical insights into tumor progression and therapy resistance.
Going green in China: Firms' responses to stricter environmental regulations
Authors: Fan Haichao , Graff Zivin Joshua , Kou Zonglai , Liu Xueyue , Wang Huanhuan 
Published: February 2025

AbstractThis paper finds that major 2006 Chinese environmental reforms creating mandatory emission reduction targets led firms to significantly reduce emissions, especially for firms in more polluting industries. A decomposition of the overall effect shows that firms relied primarily on technology upgrading (75.3%) rather than output cuts (24.7%) in meeting the regulatory changes. The driving forces for this “technique effect” are more water recycling and abatement device adoption. While polluting firms did not increase their green innovation, local equipment manufacturers—likely suppliers—did significantly increase green water patent applications, indicating an expanded environmental service market effect. Tests on firms' economic responses provide more evidence for an “internal” variant of the pollution haven hypothesis because firms' profit, capital, employment, market shares, and entry were all negatively affected by the more stringent regulation.