bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical development of ileofemoral thrombosis caused by malposition of the ileosacral screw
Authors: Grin A. A. , Darvin E. O. , Komarov V. I. 
Published: June 2024

Introduction Treatment of unstable injuries of the pelvic bones is one of the unsolved problems in modern traumatology. The instability of the injuries is determined by the nature of the destruction of the posterior semi-ring of the pelvis. The most used technique for osteosynthesis of sacral fractures for unstable pelvic injuries is ileosacral screw fixation.The purpose of the work was to demonstrate a clinical case of an iatrogenic complication: ileofemoral thrombosis caused by compression of the internal iliac vein due to malposition of the ileosacral screw.Materials and methods Medical records of a 34-year-old patient injured in a traffic accident (front seat passenger) were studied, who was referred from a district hospital on the fourth day after the injury diagnosed with a fracture of the transverse process of L2 vertebra on the left, closed fracture of the pubic and ischial bones on the left, fracture of the lateral mass of the sacrum on the right. Alcohol intoxication. Traumatic shock stage 1. Treatment results were monitored throughout the inpatient and outpatient treatment periods. Long-term follow-up was 6 months.Results Timely suspicion of the complication based on physical examination data with CT angiography that assisted to exclude internal bleeding and urgently carry out repeated surgical intervention to correct the implant malposition, reosteosynthesis of S1 body without loss of reduction, to achieve regression of the clinical picture of ileofemoral thrombosis, and also to mobilize the patient in the shortest possible time. During inpatient treatment, regression of the symptoms of the complication was achieved, the patient was fully activated, and was discharged for outpatient follow-ups.Discussion Variability in the anatomy of the sacrum and the characteristics of fractures hinder the navigation while inserting iliosacral screws, which in some cases result in malposition. Compression of the common iliac vein without damaging it causes difficulty in blood outflow and the development of a clinical picture of ileofemoral thrombosis in the early postoperative period.Conclusion This clinical case shows that X-ray images in standard views are not a reliable method for diagnosing sacral injuries and are not sufficient for preoperative planning. The use of standard C-arm did not provide sufficient intraoperative visualization to correctly assess the position of the iliosacral screw, especially in cases with sacral dysmorphia. The 3D volumetric image reconstruction significantly influenced the correct perception of the anatomical structure of the bony structures of the pelvis. Malposition of the screw and its exit to the anterior surface of the sacrum caused disruption of the iliac vein outflow and development of thrombosis in the early postoperative period.
Monitoring the expected effectiveness during the innovation project implementation in the format of scientific research
Authors: Белова Н.А. , Клименко И.С. 
Published: June 2024

Рассмотрена проблема мониторинга эффективности инновационного проекта, направленного на синтез целевой информации в процессе выполнения научного исследования. Обоснована качественная зависимость роста объема (количества) привлекаемой и генерируемой ценной информации на разных этапах его выполнения от времени. Показано, что возрастание ценности синтезируемой информации обусловлено ее последовательным структурированием от данных к метаданным и далее – к установлению закономерностей исследуемой предметной области. Показано также, что переход к оцениванию себестоимости накапливаемой информации позволяет объединить временной ресурс проекта со всеми остальными ресурсами и тем самым свести мониторинг его эффективности к контролю степени достижения целевого эффекта, состоящего в получении ожидаемого объема новых (оригинальных) результатов.
The article addresses the problem of monitoring the effectiveness of an innovative project aimed at synthesizing target information in the process of carrying out scientific research. The qualitative dependence of the growth in the volume (quantity) of attracted and generated valuable information at different stages of the project is substantiated. The article shows that the increase in the value of synthesized information is due to its sequential structuring from data to metadata and further to the establishment of patterns in the subject area. It is also shown that the transition to estimating the cost of accumulated information makes it possible to combine the time resource of the project with all other resources and, thereby, reduce the monitoring of its effectiveness to monitoring the degree of achievement of the target effect, which consists in obtaining the expected volume of new (original) results.
The remarkable effects of the non-volatile matrix of wine on the release of volatile compounds evaluated by analysing their release to the headspaces
Authors: Lopez Ricardo , Wen Yan , Ferreira Vicente 
Published: June 2024

Six Spanish wines with different wine-making styles were completely dearomatised and later reconstituted to their original volume with a standard volatile solution containing 15 wine aroma compounds with broad differences in physicochemical characteristics. The headspace composition of the reconstituted wines was evaluated using an automated dynamic headspace (DHS) method combined with thermal desorption (TD) and gas chromatography–mass spectrometry (GC–MS). This method provides a snapshot of the volatile profiles transferred to the headspace in non-equilibrium conditions. The results showed that the non-volatile matrix of the wine significantly affected the transference to the headspace of the 15 aroma compounds. Differences between wines for butanoic and hexanoic acids, DMS and vanillin are above factors 5, 4 or 3, respectively, while for ethyl acetate, ethyl decanoate, 3-methylbutan-1-ol, 2-phenylethan-1-ol or 4-ethylphenol are close to a factor 2. Only ethyl butanoate was uniformly transferred. The release of DMS was related to copper levels, while pH explained part of the release of fatty acids. However, most effects of volatility are difficult to explain. Results strongly indicate that a sample-specific correction for volatility is required to interpret the sensory effects of aroma volatiles.
Landscape of Evolutionary Arms Races between Transposable Elements and KRAB-ZFP Family
Authors: Hamada Michiaki , Kosuge Masato , Ito Jumpei 
Published: June 2024

Abstract

Transposable elements (TEs) are mobile parasitic sequences that have expanded within the host genome. It has been hypothesized that host organisms have expanded the Krüppel-associated box-containing zinc finger proteins (KRAB-ZFPs), which epigenetically suppress TEs, to counteract disorderly TE transpositions. This process is referred to as the evolutionary arms race. However, the extent to which this evolutionary arms race occurred across various TE families remains unclear. In the present study, we systematically explored the evolutionary arms race between TE families and KRAB-ZFPs using public ChIP-seq data. We discovered and characterized new instances of evolutionary arms races with KRAB-ZFPs in endogenous retroviruses.　Furthermore, we found that the regulatory landscape shaped by this arms race contributed to the gene regulatory network. In summary, our results provide insight into the impact of the evolutionary arms race on TE families, the KRAB-ZFP family, and host gene regulatory networks.
Evaluating the Impact of an Online Educational Module on Nursing Students’ Competencies Related to Autism Spectrum Disorder
Authors: Salehi Mohammad , Nikaiin Behi , Matiullah Jawaher , Mollazehi Mohammad 
Published: June 2024

Abstract

This research study investigates whether online training of nursing students enhances autism cultural competency. In the recent past, there has been a significant increase in global autism spectrum disorder incidents, particularly in low and middle-income nations. While recognizing the increased autism spectrum disorder cases, the research emphasizes the need for comprehensive care training for nursing students. This study employs a pragmatic quasi- experimental method to assess the impact of online training modules on nursing students' attitudes, competencies, and knowledge at the University of Calgary in Qatar. A total of 155 second and third-year nursing students completed tests that assessed their cultural competencies and perceived confidence. Based on the Likert scale responses, the online module has significantly improved participants' cultural competence and knowledge. The descriptive statistics pinpoint the areas needing more focus to ensure holistic care for autism patients. The overall research findings showed a significant impact of online training on autism cultural competency. Therefore, the results suggest the efficiency of online training nursing programs associated with autism care. The study outcomes illustrate the benefits of increased awareness, reduced stigma, advanced diagnosis, and effective collaboration among healthcare professionals. As the study concludes, it recommends allocating more funding to facilitate comprehensive autism research in Qatar.
Identification and exploration of potential N6-methylation related mRNAs in endometriosis
Authors: He Yanan , Ren Chengcheng , Lei Liang , Hu Zihan , Li Jixin , Cheng Yan , Sun Liyuan , Zhang Guangmei 
Published: June 2024

Abstract

Background: N6-methyladenosine(m6A) modification regulates the processes of RNA splicing, subcellular localization, translation and stability by changing the RNA structure and the interaction between RNA and RNA-binding proteins to ensure the timely and accurate expression of genes. In this study, we investigated m6A-related mRNAs and for the first time explored effective prevention and treatment targets in endometriosis (EM).
Methods: By arraystar m6A-mRNA epitranscriptomic microarray, biological information analysis technologies, and validation of other databases, aberrant m6A- related mRNAs were uncovered, as well as efficient therapeutic drugs.
Results: FN1, VCAM1, RAP1A, BRCA1, CCNA2 and CDK1 might be vital m6A-related mRNAs, and VCAM1 and RAP1A may be the most important two. A few crucial small-molecule agents supply new views for the treatment of EM.
Conclusion: These results demonstrated novel insights into m6A modification of EM and revealed potential biomarkers and precision medicine strategies for EM.
Unveiling Cotton's Defense: Harnessing GthZIM17-1 Inhibition for Verticillium Wilt Resistance
Authors: Yang Mengying , Magwanga Richard Odongo , Hou Yuqing , Umer Muhammad Jawad , Wang Heng , Liu Yiman , Han Jiale , Liu Qiankun , Zheng Jie , Xu Yanchao , Wang Yuhong , Kirungu Joy Nyangasi , Liu Fang , Zhou Zhongli , Cai Xiaoyan 
Published: June 2024

Abstract

Background
Verticillium wilt (VW) is one of the major biotic stress factors in cotton production, causing a significant reduction in yields and quality reduction. Even though extensive molecular research has been carried out on V. wilt, the molecular basis of Verticillium dahliae host response has not been extensively explored. In this research work, the ZIM17, a zinc finger motif protein, was investigated through genome-wide identification, and forward and reverse gene functional analysis to explore the role of ZIM17 in six cotton germplasms. Based on the transcription data, GthZIM17-1 was further explored through Virus-Induced gene silencing (VIGS), overexpression, and protein-protein interaction.
Results
A total of 23 ZIM17 genes were identified across the six cotton species, and were phylogenetically grouped into three clusters, designated A, B, and C. The entire gene family was characterized by Motif 1 and 3. The knockdown of the novel gene, GhZIM17-4, revealed significantly enhanced resistance to V. wilt due to increased lignification with significantly low DAB staining, moreover, the overexpressed (OE) Arabidopsis thaliana, recorded the disease index (DI) percentage above 70% and above compared to the wild type. Moreover, disease-resistant genes GhPR1, GhPR3, and GhPDF1,2 were significantly upregulated in the VIGS-plants compared to the none VIGS-plants.
Conclusion
The findings therefore provide proof that the ZIM17 gene family plays an integral role of promoting Verticillium wilt, and suppression of its expression in the elite cotton cultivars will contribute significantly in reducing the V. Wilt infection, thereby improving the yield levels in cotton. Moreover, the ZIM17 has a homologous gene type in yeast, thus knockdown of the novel gene in cotton, has a similar effect to that of host-induced gene silencing (HIGS) mechanism.
Reusable and effective multi-biocatalyst system for transformation of glycerol to value-added dihydroxyacetone
Authors: Wee Youngho , Kumar Gudi Satheesh , Kim Seongbeen , Zhao Xueyan Sarah , Wang Ping , Lee Jinwoo , Hwang Ee Taek , Kim Jungbae 
Published: June 2024

Abstract

Glycerol-based biorefinery can be a highly profitable process by producing highly value-added products such as dihydroxyacetone via combined catalytic strategies. Here, two-enzyme system is adopted for cofactor regeneration as well as the transformation of glycerol into highly-valuable dihydroxyacetone. Glycerol dehydrogenase (GDH) and alcohol dehydrogenase (ADH) are co-immobilized within magnetically-separable and spherical mesocellular silica foam (Mag-S-MCF). GDH and ADH are adsorbed into the mesopores of Mag-S-MCF, and further crosslinked within the mesopores of Mag-S-MCF. The resulting nanoscale enzyme reactors (NER) of GDH and ADH within the mesopores can effectively prevent crosslinked enzyme aggregates from being leached out of mesopores, due to the bottle-neck mesopore structure of Mag-S-MCF, as well as stabilize the activity of GDH and ADH upon chemical crosslinking, effectively preventing the denaturation of enzyme molecules. The proximity of GDH and ADH molecules within mesopores of NER improves the efficiency of cofactor-mediated dual-enzymatic reactions by relieving mass-transfer limitations and improving cofactor recycling, expediting both glycerol oxidation and dihydroxyacetone generation. As a result, the DHA concentration obtained from NER-(GDH/ADH) and (NER-GDH)/(NER-ADH), with cofactor recycling, were 410 and 336 µM, respectively. To the best of our knowledge, this report is the first demonstration of stabilized nanoscale multi-enzyme reactor system, equipped with efficient cofactor regeneration within mesopores, for efficient glycerol transformation to high-valued dihydroxyacetone.
Trophic interaction and livestock dependence of snow leopard and sympatric carnivores in Tianshan, Northwest China.
Authors: Zhong Hua , Atzeni Luciano , Li Fengjiao , Liu Yixuan , Wang Ruifen , Alemiti Abduzaire , Shi Kun 
Published: June 2024

Abstract

Diets of carnivores provide insights into predator-prey relationship and intra-guild competition, and contribute to drafting fruitful conservation strategies. However, few high-resolution dietary dataset of carnivores exist in Central Asia, hindering deep understanding of their coexistence in grazing landscape. Here, we present detailed trophic interaction among four carnivores in Tianshan Mountains of Northwest China deriving from 179 fecal samples. Using DNA metabarcoding, we identified 20 prey items across 5 orders. High dietary overlap (Ojk = 0.995) was found between snow leopard (Panthera uncia) and wolf (Canis lupus), which mainly preyed on large mammals (%PR = 85%, 91%). Red fox (Vulpes vulpes) mainly consumed large and small mammals (%PR = 43%, 31%). Significant differences (P < 0.001, P < 0.05) and lower dietary overlaps (Ojk = 0.761, 0.756) were observed between red fox and snow leopard/wolf. Wild animals such as ibex (Capra sibirica) were detected in the diet of dog (Canis lupus familiaris), indicating wildlife depredation. High dietary overlaps were observed between dog and snow leopard/wolf (Ojk = 0.989, 0.999). These results suggest that dog compete with wild predators for prey resources and underline the need to further study their potential disturbance to natural ecosystems. All carnivores consumed livestock (%PR = 14 ~ 27%). Corrals reinforcement and husbandry practice improvement are necessary to prevent potential economic losses and retaliatory killing. Our results suggest that dietary partitioning and livestock subsidies facilitate carnivore coexistence in Tianshan and have implications for developing effective conservation intervention to promote human-carnivore coexistence in Central Asia.
Inoculation of microalgae distinctly shapes the structure and enhances the stability of eukaryotic plankton community in shrimp rearing water
Authors: Xiang Jie , Lian Chen , Cai Huifeng , Ke Jiangdong , Ni Heng , Zhu Jinyong , Lu Kaihong , Zheng Zhongming , Yang Wen 
Published: June 2024

Abstract

Inoculating microalgae has been verified to have the potential to improve the microenvironment of shrimp rearing water and modulate bacterial communities. However, the impact of this intervention on the water eukaryotic plankton community remains relatively unexplored. In this study, we inoculated two indigenous microalgae, Nannochloropsis oculata and Thalassiosira weissflogii, into shrimp rearing water to elucidate the dynamics and interactions among microalgae, nutrient factors, and the small-sized (0.22-3 μm) and large-sized (3-200 μm) eukaryotic plankton community. Our findings demonstrated significant differences in the composition and diversity the small-sized (0.22-3 μm) and large-sized (3-200 μm) eukaryotic plankton community under various microalgae treatments. PERMANOVA (permutational multivariate analysis of variance) revealed significant differences among treatments in terms of rearing time and Size fraction. Moreover, partial least squares path modeling (PLS-PM) analysis showed that microalgae and nitrite could directly affect the small-sized community or indirectly affect them through trophic interactions. According to the neutral community model, inoculation of microalgae amplifies the relative contribution of deterministic processes in community assembly. Furthermore, the average variation degree (AVD) index analysis results indicated that the inoculation of N. oculata was particularly effective in enhancing community stability. These results indicate the importance of microalgae in shaping the structure and stability of eukaryotic plankton communities in shrimp rearing water, which holds great promise for the understanding and development of technologies aimed at improving the quality of rearing water, thereby contributing to more successful shrimp cultivation practices.
Understanding the Flood Seasonality in the Himalayan River Basin under Changing Climate
Authors: Singhal Prachi , Goel Narendra K. , Bronstert Axel , Vormoor Klaus , Agarwal Ankit , Arora Manohar 
Published: June 2024

Abstract

This study addresses critical knowledge gaps about climate change impacts on hydrology in a highly vulnerable and strategically important region. A sub-catchment, namely Sarasgaon in the Bhilangana River basin in the Central Himalayas, was analyzed using observed and projected future climate data for rainfall and temperature. Examining the maximum monthly rainfall data provided by the India Meteorological Department (IMD) spanning from 1901 to 2020 reveals a noteworthy shift in the peak towards earlier months, particularly up to June. This observation suggests compelling evidence of seasonal changes in flood peaks potentially associated with a warming climate scenario. On comparison of different data sets with observed data sets, it is found that the Indian Meteorological Department (IMD) precipitation dataset best matched the observations. The projected climate ensemble of the chosen dataset (NEX-GDDP) required significant correction, and quantile-based mapping was used to counter underestimation. The hydrological modeling was done with the CemaNeige_GR4J hydrological model in the airGR package in R software to project the changes in floods for past and future scenarios. The model was calibrated with observed discharge data for Sarasgaon for 2016-2018 and validated with data for 2018-2021. Nash-Sutcliffe Efficiency (NSE) values of 0.79 and 0.73, respectively, were obtained. The simulation was done for Historical (1971-1999), RCP 4.5 (2071-2099), and RCP 8.5 (2071-2099) scenarios using calibrated parameters. The results indicated the possibility of vanishing snowpacks in the study area. Due to higher temperatures and precipitation in the future scenarios concerning the Historical (1971-1999) period, the simulated discharge series of RCP 8.5 (2071-2099) is found to be magnitude-wise higher than that of RCP 4.5 (2071-2099), which in turn is found to be higher than that of the Historical (1971-1999) during the monsoon season. The results of the time of occurrence of annual maximum flood peaks indicate a possible early shift of the future streamflows (combination of snowmelt and rainfall-induced floods) over the study region. This shows the possible occurrences of changes in floods, though we are well aware of the high uncertainties of projected future precipitation and temperature conditions and projected future streamflows. The study highlights the potential impact of climate change on floods in the Garhwal Himalayas region, emphasizing the importance of understanding different flood-generating regimes for better preparedness against natural hazards. The findings underscore the need for ongoing research and adaptation strategies in the Himalayan region to address the uncertainties associated with projected future precipitation and temperature conditions.
Hysterectomy and mental health status, findings from Ardakan Cohort Study on Aging (ACSA)
Authors: Hedayati Fatemeh , Delbari Ahmad , Haddadi Mohammad , Akbarzadeh Isa , Azimi Amirali , Eftekhar Tahereh , Hantoushzadeh Sedigheh , Tabatabaei Fatemeh Sadat 
Published: June 2024

Abstract

Background
Many middle-aged and older women have undergone hysterectomy in their lifetime. The mental health outcomes of hysterectomy are controversial. This study aimed to evaluate depression and anxiety association with hysterectomy, with or without oophorectomy.
Methods
This cross-sectional study used data from the first phase of the Ardakan Cohort Study on Aging (ACSA). The population of this study included women aged ≥ 50 years recruited through multilevel stratified random sampling. Data on menopausal age, hysterectomy status, hormone replacement therapy, number of children, exercise frequency, financial situation, educational background, household conditions, occupational status, and stressful life events were collected. Mental health status was assessed using the Center for Epidemiologic Studies Short Depression Scale-10 (CESD-10) for depression and the Hospital Anxiety and Depression Scale (HADS) for anxiety. Statistical analysis, including linear and logistic regression, compared three groups: those with no hysterectomy, those with hysterectomy with oophorectomy, and those without oophorectomy.
Results
Among 2,252 menopausal women, 450 (19.9%) underwent hysterectomy with oophorectomy, and 101 (4.4%) underwent hysterectomy without oophorectomy. After accounting for all factors, no association was found between hysterectomy and mental health. Subsequent analysis among those with a history of hysterectomy revealed that individuals 10–15 years post-hysterectomy experienced a 56% reduction in depression compared to those less than 10 years post-hysterectomy (p-value = 0.043). However, this association was not observed for anxiety.
Conclusions
There was no association between hysterectomy, with or without oophorectomy, and depression or anxiety. Further research is warranted to explore the mental health outcomes associated with hysterectomy.