bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adolescent Athletes with Stronger Athletic Identity Perceptions Have Weaker Fear Avoidance Perceptions During Musculoskeletal Injury Rehabilitation Return to Sports Preparation
Authors: Ferman Basha , Nyland John , Richards Jarod , Krupp Ryan 
Published: May 2024

Background:
Adolescent athletes who sustain a musculoskeletal sports injury are at high re-injury risk. This prospective study evaluated athletic identity perception and fear avoidance perception relationships during the return to sport preparation phase of musculoskeletal injury rehabilitation.

Methods:
From 140 consecutive physical therapy outpatients, 50 (26 females, 24 males) adolescent athletes (mean age 16.8, range 14 to 22 y) completed the 7-item Athletic Identity Measurement Scale (AIMS), the 10-item Athletic Fear Avoidance Questionnaire (AFAQ), and the AFAQ with 2 additional movement-related fear and pain questions (AFAQ+). Correlational analysis was performed of overall AIMS and AIMS subscale scores (social identity, exclusivity, negative affectivity), with AFAQ and AFAQ+ scores (P≤0.05).

Results:
Adolescent athletes were receiving treatment for musculoskeletal injuries sustained during soccer (n=10), lacrosse (n=7), baseball (n=6), basketball (n=5), volleyball (n=5), track or cross country (n=4), American football (n=4), field hockey or ice hockey (n=3), softball (n=2), tennis (n=2), and gymnastics (n=2). Lower extremity conditions included anterior cruciate ligament reconstruction (n=23) or other lower extremity conditions (n=17). Upper extremity conditions included shoulder dislocation or labral repair (n=6), elbow sprain or fracture (n=3), and clavicle fracture (n=1). The AIMS score displayed moderate inverse relationships with AFAQ (r=−0.40, P=0.008) and AFAQ+ (r=−0.41, P<0.004) scores. The “social identity” AIMS subscale score displayed a moderate inverse relationship with AFAQ (r=− 0.48, P<0.001) and AFAQ+ (r=−0.46, P=0.001) scores. The “exclusivity” AIMS subscale score displayed moderate inverse relationships with AFAQ (r=−0.40, P=0.005) and AFAQ+ (r=−0.46, P=0.001) scores. The “negative affectivity” subscale did not display significant relationships with AFAQ or AFAQ+ scores. Subject age displayed moderate inverse relationships with the AIMS “social identity” (r=−0.56, P<0.001) and “exclusivity” (r=−0.42, P=0.004) subscale scores and weak direct relationships with AFAQ (r=0.30, P=0.04) and AFAQ+ (r=0.32, P=0.02) scores.

Conclusion:
Adolescent athletes with stronger athletic identity perceptions during the return to the sports preparation phase of musculoskeletal injury rehabilitation had weaker fear avoidance perceptions. As age increased from early to late adolescence, athletic identity perceptions became weaker, and fear avoidance perceptions became stronger. To decrease re-injury rates, early identification and surveillance of injured adolescent athletes with stronger, more exclusive athletic identity perceptions and weaker fear avoidance perceptions may influence rehabilitation progression and return to play decisions.

Level of Evidence:
Level—II, prospective cohort, correlational study.
False-positive Findings of Large Vessel Vasculitis on FDG-PET in Patients Treated With Immune Checkpoint Inhibitors
Authors: Johnson Dylan , Jamal Shahin , Hung Ryan W. , Ye Carrie 
Published: May 2024

Fluorine-18 fluorodeoxygluocose positron emission tomography (FDG-PET) is increasingly used in the evaluation of response to immune checkpoint inhibitor (ICI) therapy. Incidental findings of increased vessel wall uptake may prompt the concern for ICI-induced large vessel vasculitis (LVV). Precise radiographic and clinical evaluation is required to determine if this represents true vasculitis, as use of immune suppression and ICI discontinuation can have significant impacts on patient outcomes. We performed a retrospective case analysis of 4 consecutive patients referred to 2 rheumatology clinics treated with ICI with incidental findings of LVV on FDG-PET, reviewing their clinical course and radiographic findings. All 4 cases had FDG-PET scans for routine oncology indications and had no associated clinical features of LVV. One patient was treated with corticosteroids and no patients developed any clinical evidence of vasculitis during a mean follow-up period of 17 months (range: 7–33 mo). All FDG-PET images reporting LVV underwent a standardized analysis to identify any technical issues or concerns with interpretation. In review of imaging, 3 of the cases may have been due to delayed tracer to scan interval leading to misinterpretation of vascular uptake as suspected LVV. Recognition of technical pitfalls in FDG-PET interpretation is crucial to inform the need for immunosuppression and the safety of continued ICI therapy.
The Effectiveness of Collaborative Advanced Practice Nursing in Primary Hypertension Management
Authors: Duller Sarla F. , Tejero Lourdes Marie S. , Tating Dan Louie Renz P. 
Published: May 2024

Background
Hypertension is a global health concern that is best managed at the primary care level. In low- and middle-income countries (LMICs) facing resource constraints, collaboration between well-prepared entry-level advanced practice nurses (APNs) and physicians (medical doctors [MDs]) can enhance the care of patients with primary hypertension.

Objective
The purpose of this study was to evaluate the effectiveness of collaborative entry-level APNs in primary hypertension management, including patient knowledge, physiological and behavioral outcomes, consultation length, and patient satisfaction.

Methods
Sixty-three eligible patients were randomly assigned to either an entry-level APN intervention group or a control group with MDs. Three master's-prepared nurses, trained in hypertension management, acted as entry-level APNs, following the Joint National Committee guidelines in collaboration with a physician. The control group underwent standard clinic consultations. After 1 month, a mixed analysis of variance was used to assess intervention effectiveness, examining both between-groups and within-groups outcomes.

Results
Both groups shared similar sociodemographic and baseline characteristics. Significant improvements in blood pressure, body mass index, knowledge, self-management, and medication adherence were found at the 1-month follow-up, with no significant differences in outcomes or patient satisfaction between the entry-level APN and MD groups. However, clinical consultation time was significantly longer for entry-level APNs than for MDs.

Conclusions
Collaborative entry-level APNs managing primary hypertension are comparable with MD care; however, larger, longer trials are essential for a thorough assessment. Strengthening the development of entry-level advanced practice nursing roles in low- and middle-income countries is crucial for addressing service gaps in primary hypertension and other chronic diseases.
Incidental Detection of Second Primary Thyroid Malignancy in Patients of Metastatic Castration-Resistant Prostate Carcinoma
Authors: Nazar Aamir , Kalshetty Ashwini , Basu Sandip 
Published: May 2024

Abstract
Second primary tumors are being increasingly detected owing to and in proportion to the use of advanced imaging modalities including PET/CT. Patients suffering from prostate cancer have been reported to have increased second primary cancers of gastrointestinal tract, urinary bladder, and thyroid. We herein describe incidental detection of thyroid carcinoma, in 2 patients of mCRPC (metastatic castration-resistant prostate carcinoma) undergoing preradioligand therapy workup, on 68Ga–prostate-specific membrane antigen PET/CT initially, subsequently also observed on multitracer PET/CT (64CuCl2 and 18F-FDG). Thus, the potential of PET/CT for early in vivo second primary detection in mCRPC setting is illustrated in the aforementioned 2 patients.
Alternatives to the Gold Standard: A Systematic Review of Profunda Artery Perforator and Lumbar Artery Perforator Flaps for Breast Reconstruction
Authors: Minkhorst Kathryn , Castanov Valera , Li Erica Ai , Farrokhi Kaveh , Jaszkul Katrina M. , AlGhanim Khalifa , DeLyzer Tanya , Simpson Andrew M. 
Published: May 2024

Introduction
Breast reconstruction with the deep inferior epigastric perforator (DIEP) flap is the current gold-standard autologous option. The profunda artery perforator (PAP) and lumbar artery perforator (LAP) flaps have more recently been described as alternatives for patients who are not candidates for a DIEP flap. The aim of this study was to review the survival and complication rates of PAP and LAP flaps, using the DIEP flap as a benchmark.

Methods
A literature search was conducted using PubMed, MEDLINE, Embase, BIOSIS, Web of Science, and Cochrane databases. Papers were screened by title and abstract, and full texts reviewed by three independent blinded reviewers. Quality was assessed using MINORS criteria.

Results
Sixty-three studies were included, for a total of 745 PAP, 62 stacked PAP, 187 LAP, and 23,748 DIEP flap breast reconstructions. The PAP (98.3%) had comparable success rate to DIEP (98.4%), and the stacked PAP (88.7%) and LAP (92.5%) success rate was significantly lower (P < 0.0001). The PAP and LAP groups both had a low incidence of fat necrosis. However, the revision rate for the LAP group was 16.1% whereas the PAP group was 3.3%. Donor site wound dehiscence rate was 2.9 in the LAP group and 9.1% in the PAP group.

Conclusions
Profunda artery perforator and DIEP flaps demonstrate very high rates of overall survival. The LAP flap has a lower survival rate. This review highlights the survival and complication rates of these alternative flaps, which may help clinicians in guiding autologous reconstruction technique when a DIEP flap is unavailable.
Utility of a Neuromuscular Activation Exercise Protocol on Surgeon Posture
Authors: Yessaillian Andrea L. , Clark Robert C. , Segal Rachel M. , Angers Kori , Gosman Amanda A. , Reid Chris M. 
Published: May 2024

Background
Surgeons are at risk for musculoskeletal disorders from ergonomic strain in the operating room. These deficits may stem from neuromuscular control deficits. Neuromuscular activation exercises (NMEs) may strengthen the brain-muscle connection. This study aimed to assess the utility of a surgeon-oriented NME protocol on posture.

Methods
Surgeons, operating room staff, and medical students completed a professionally established NME routine. An electronic application, PostureScreen®, assessed participants' posture. A long-term cohort was assessed before and after a 2 to 6-week routine. A short-term cohort was assessed immediately before and after completion. All participants additionally completed a postintervention survey.

Results
After intervention, the short-term cohort (n = 47) had significantly reduced frontal and sagittal postural deviation (P < 0.05). A significant decrease in effective head weight was additionally demonstrated with decreased neck flexion and increased cerebral-cervical symmetry (P < 0.05).
The long-term cohort (n = 6) showed a significant postintervention decrease in lateral and anterior shoulder translation (P < 0.05). Total anterior translational deviations demonstrated trend-level decrease (P = 0.078). This demonstrates that after intervention, participants' shoulders were more centered with the spine as opposed to shifted right or left. Survey results showed participants favored exercises that immediately brought relief of tension.

Conclusions
A decrease in postural deviations associated with NME in both cohorts demonstrates NME as a potential mechanism to protect surgeon musculoskeletal health and improve well-being. Survey results demonstrate areas of refinement for NME protocol design.
Type-specific whole blood still has a role in the era of low-titer O universal donor transfusion for severe trauma hemorrhage
Authors: Milford Elissa M. , Gurney Jennifer M. , Beckett Andrew , Strandenes Geir , Reade Michael C. 
Published: May 2024

ABSTRACTWhole blood can be ABO-type specific (type-specific whole blood (TSWB)) or low-titer O universal donor (low-titer O whole blood (LTOWB)). Having previously used LTOWB, the US Armed Forces Blood Program began using TSWB in 1965 as a method of increasing the donor pool. In contrast to military practice, the Association for the Advancement of Blood and Biotherapies formerly the American association of blood banks (AABB), from its first guidelines in 1958 until 2018, permitted only TSWB. Attempting to reduce time to transfusion, the US military reintroduced LTOWB in the deployed environment in 2015; this practice was endorsed by the AABB in 2018 and is progressively being implemented by military and civilian providers worldwide. Low-titer O whole blood is the only practical solution prehospital. However, there are several reasons to retain the option of TSWB in hospitals with a laboratory. These include (1) as-yet ill-defined risks of immunological complications from ABO-incompatible plasma (even when this has low titers of anti-A and -B), (2) risks of high volumes of LTOWB including published historical advice (based on clinical experience) not to transfuse type-specific blood for 2 to 3 weeks following a substantial LTOWB transfusion, (3) uncertainty as to the optimal definition of “low titer,” and (4) expanding the potential donor pool by allowing type-specific transfusion. Several large randomized controlled trials currently underway are comparing LTOWB with component therapy, but none address the question of LTOWB versus TSWB. There are sufficient data to suggest that the additional risks of transfusing LTOWB to non–group O recipients should be avoided by using TSWB as soon as possible. Combined with the advantage of maintaining an adequate supply of blood products in times of high demand, this suggests that retaining TSWB within the civilian and military blood supply system is desirable. TSWB should be preferred when patient blood group is confirmed in facilities with a hematology laboratory, with LTOWB reserved for patients whose blood group is unknown.
Endothelial dysfunction is dampened by early administration of fresh frozen plasma in a rodent burn shock model
Authors: Kelly Edward J. , Ziedins Eriks E. , Carney Bonnie C. , Moffatt Lauren T. , Shupp Jeffrey W. 
Published: May 2024

BACKGROUND
Endothelial dysfunction has been implicated in the pathogenesis of burn shock affecting patients with large thermal injury. In response to injury, glycocalyx components like Syndecan-1 (SDC-1) are shed into circulation and have been used as markers of endothelial damage. Previous work in our laboratory has shown that plasma inclusive resuscitation (PIR) with fresh frozen plasma (FFP) ameliorates endothelial damage. However, there remains a paucity of information regarding optimal timing and dosing of PIR as well as organ-specific endothelial responses to shock. We aimed to examine the impact of PIR on endothelial dysfunction using clinically translatable timing and dosing.

METHODS
Sprague-Dawley rats were used to create thermal burns. Rats were subjected to 40% total body surface area scald burns and were resuscitated with lactated Ringer's (LR) only, LR plus albumin, and LR plus early 1 mL boluses of FFP at 0, 2, 4, and 8 hours postinjury. A late group also received LR plus FFP starting at hour 10 postinjury. Syndecan-1 levels were quantified by enzyme-linked immunosorbent assay, and quantitative real-time polymerase chain reaction analysis characterized transcription of glycocalyx components and inflammatory cytokines in the lung and spleen. Evan's blue dye was used to quantify amount of vascular leakage.

RESULTS
Lactated Ringer's plus early FFP reduced Evan's blue dye extravasation when compared with LR only groups, while late FFP did not. When comparing LR only versus LR plus early FFP, SDC-1 levels were reduced in the LR plus early FFP group at hours 8, 12, and 24 (5.23 vs. 2.07, p < 0.001; 4.49 vs. 2.05, p < 0.01; and 3.82 vs. 2.08, p < 0.05, respectively). Lactated Ringer's only groups had upregulation of Exostosin-1 and SDC-1 in the lung compared with LR plus early FFP groups (p < 0.01 and p < 0.05) and upregulation of cytokines interluekin-10 and interferon γ (p < 0.001 and p < 0.001).

CONCLUSION
Early administration of LR plus FFP reduces the magnitude of SDC-1 shedding and dampens the cytokine response to injury. The upregulation of glycocalyx components as a response to endothelial injury is also decreased in the lung and spleen by LR plus early FFP administration.
Exploring the role of vocalizations in regulating group dynamics
Authors: Xie Bing , Brask Josefine B. , Dabelsteen Torben , Briefer Elodie F. 
Published: May 2024

Because of the diverging needs of individuals, group life can lead to disputes and competition, but it also has many advantages, such as reduced predation risk, information sharing and increased hunting success. Social animals have to maintain group cohesion and need to synchronize activities, such as foraging, resting, social interactions and movements, in order to thrive in groups. Acoustic signals are highly relevant for social dynamics, some because they are long-ranging and others because they are short-ranging, which may serve important within-group functions. However, although there has been an increase in studies concentrating on acoustic communication within groups in the past decade, many aspects of how vocalizations relate to group dynamics are still poorly understood. The aim of this review is to present an overview of our current knowledge on the role of vocalizations in regulating social group dynamics, identify knowledge gaps and recommend potential future research directions. We review the role that vocalizations play in (i) collective movement, (ii) separation risk and cohesion maintenance, (iii) fission–fusion dynamics, and (iv) social networks. We recommend that future studies aim to increase the diversity of studied species and strengthen the integration of state-of-the-art tools to study social dynamics and acoustic signals.
This article is part of the theme issue ‘The power of sound: unravelling how acoustic communication shapes group dynamics’.
Collective signalling is shaped by feedbacks between signaller variation, receiver perception and acoustic environment in a simulated communication network
Authors: Reichert Michael S. , Luttbeg Barney , Hobson Elizabeth A. 
Published: May 2024

Communication takes place within a network of multiple signallers and receivers. Social network analysis provides tools to quantify how an individual’s social positioning affects group dynamics and the subsequent biological consequences. However, network analysis is rarely applied to animal communication, likely due to the logistical difficulties of monitoring natural communication networks. We generated a simulated communication network to investigate how variation in individual communication behaviours generates network effects, and how this communication network’s structure feeds back to affect future signalling interactions. We simulated competitive acoustic signalling interactions among chorusing individuals and varied several parameters related to communication and chorus size to examine their effects on calling output and social connections. Larger choruses had higher noise levels, and this reduced network density and altered the relationships between individual traits and communication network position. Hearing sensitivity interacted with chorus size to affect both individuals’ positions in the network and the acoustic output of the chorus. Physical proximity to competitors influenced signalling, but a distinctive communication network structure emerged when signal active space was limited. Our model raises novel predictions about communication networks that could be tested experimentally and identifies aspects of information processing in complex environments that remain to be investigated.
This article is part of the theme issue ‘The power of sound: unravelling how acoustic communication shapes group dynamics’.
Hidden social complexity behind vocal and acoustic communication in non-avian reptiles
Authors: Lin Feng-Chun , Lin Si-Min , Godfrey Stephanie S. 
Published: May 2024

Social interactions are inevitable in the lives of most animals, since most essential behaviours require interaction with conspecifics, such as mating and competing for resources. Non-avian reptiles are typically viewed as solitary animals that predominantly use their vision and olfaction to communicate with conspecifics. Nevertheless, in recent years, evidence is mounting that some reptiles can produce sounds and have the potential for acoustic communication. Reptiles that can produce sound have an additional communicative channel (in addition to visual/olfactory channels), which could suggest they have a higher communicative complexity, the evolution of which is assumed to be driven by the need of social interactions. Thus, acoustic reptiles may provide an opportunity to unveil the true social complexity of reptiles that are usually thought of as solitary. This review aims to reveal the hidden social interactions behind the use of sounds in non-avian reptiles. Our review suggests that the potential of vocal and acoustic communication and the complexity of social interactions may be underestimated in non-avian reptiles, and that acoustic reptiles may provide a great opportunity to uncover the coevolution between sociality and communication in non-avian reptiles.
This article is part of the theme issue ‘The power of sound: unravelling how acoustic communication shapes group dynamics’.
Evaluation of enzyme activity predictions for variants of unknown significance in Arylsulfatase A
Authors: Jain Shantanu , Trinidad Marena , Nguyen Thanh Binh , Jones Kaiya , Neto Santiago Diaz , Ge Fang , Glagovsky Ailin , Jones Cameron , Moran Giankaleb , Wang Boqi , Rahimi Kobra , Çalıcı Sümeyra Zeynep , Cedillo Luis R. , Berardelli Silvia , Özden Buse , Chen Ken , Katsonis Panagiotis , Williams Amanda , Lichtarge Olivier , Rana Sadhna , Pradhan Swatantra , Srinivasan Rajgopal , Sajeed Rakshanda , Joshi Dinesh , Faraggi Eshel , Jernigan Robert , Kloczkowski Andrzej , Xu Jierui , Song Zigang , Özkan Selen , Padilla Natàlia , de la Cruz Xavier , Acuna-Hidalgo Rocio , Grafmüller Andrea , Jiménez Barrón Laura T. , Manfredi Matteo , Savojardo Castrense , Babbi Giulia , Martelli Pier Luigi , Casadio Rita , Sun Yuanfei , Zhu Shaowen , Shen Yang , Pucci Fabrizio , Rooman Marianne , Cia Gabriel , Raimondi Daniele , Hermans Pauline , Kwee Sofia , Chen Ella , Astore Courtney , Kamandula Akash , Pejaver Vikas , Ramola Rashika , Velyunskiy Michelle , Zeiberg Daniel , Mishra Reet , Sterling Teague , Goldstein Jennifer L. , Lugo-Martinez Jose , Kazi Sufyan , Li Sindy , Long Kinsey , Brenner Steven E. , Bakolitsa Constantina , Radivojac Predrag , Suhr Dean , Suhr Teryn , Clark Wyatt T. 
Published: May 2024

AbstractContinued advances in variant effect prediction are necessary to demonstrate the ability of machine learning methods to accurately determine the clinical impact of variants of unknown significance (VUS). Towards this goal, the ARSA Critical Assessment of Genome Interpretation (CAGI) challenge was designed to characterize progress by utilizing 219 experimentally assayed missense VUS in theArylsulfa-tase A(ARSA) gene to assess the performance of community-submitted predictions of variant functional effects. The challenge involved 15 teams, and evaluated additional predictions from established and recently released models. Notably, a model developed by participants of a genetics and coding bootcamp, trained with standard machine-learning tools in Python, demonstrated superior performance among sub-missions. Furthermore, the study observed that state-of-the-art deep learning methods provided small but statistically significant improvement in predictive performance compared to less elaborate techniques. These findings underscore the utility of variant effect prediction, and the potential for models trained with modest resources to accurately classify VUS in genetic and clinical research.