bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elevated Bone Turnover Predicts for Bone Metastasis in Postmenopausal Breast Cancer: Results of NCIC CTG MA.14
Authors: Lipton Allan , Chapman Judy-Anne W. , Demers Laurence , Shepherd Lois E. , Han Lei , Wilson Carolyn F. , Pritchard Kathleen I. , Leitzel Kim E. , Ali Suhail M. , Pollak Michael 
Published: August 2011

Purpose We investigated the association of bone-only relapse with a pretreatment marker of bone resorption: serum beta C-terminal telopeptide (B-CTx) of type I collagen. Methods Pretreatment serum B-CTx concentrations were determined from 621 of 667 patients with primary breast cancer enrolled onto the NCIC CTG MA.14 phase III adjuvant trial of tamoxifen with or without octreotide. Recurrence-free survival (RFS) was a secondary end point; the focus here was bone-only relapse. We analyzed continuous or categorical (.71 ng/mL cut point) serum B-CTx in stepwise forward multivariate Cox regression, adjusted for trial stratification factors. We also examined B-CTx and bone relapse by pretrial chemotherapy status. Results At median 7.9 years follow-up, 123 of 621 patients experienced recurrence; 19 (3.1%) of 621 had bone-only recurrence, and 47 (7.5%) of 621 had bone plus other sites of recurrence. Larger pathologic tumor size (P = .001) and elevated continuous and categorical serum B-CTx were associated with shorter bone-only RFS (both P = .02) when added to a model with factors significant in the main trial analyses (hazard ratio [HR], 3.43 and 3.50, respectively; 95% CI, 1.20 to 9.77 and 1.26 to 9.75, respectively). The univariate HR for B-CTx was 2.80 (95% CI, 1.05 to 7.48; P = .03). Elevated serum B-CTx was also associated with shorter bone-only RFS (P = .02) when added to a model with factors significant in the main trial analyses. Serum B-CTx level was not associated with any other type of recurrence. Serum B-CTx was not significantly different for patients who underwent pretrial chemotherapy, compared with those who did not (P = .27), nor did pretrial chemotherapy affect bone relapse (P = .48 for bone only; P = .76 for bone with other relapse). Conclusion Higher pretreatment serum B-CTx was a significant predictor of shorter RFS for bone-only metastasis. Increased bone resorption creates an environment that promotes growth of breast cancer cells.
Randomized Phase II Placebo-Controlled Trial of Maintenance Therapy Using the Oral Triple Angiokinase Inhibitor BIBF 1120 After Chemotherapy for Relapsed Ovarian Cancer
Authors: Ledermann Jonathan A. , Hackshaw Allan , Kaye Stan , Jayson Gordon , Gabra Hani , McNeish Iain , Earl Helena , Perren Tim , Gore Martin , Persic Mojca , Adams Malcolm , James Lindsay , Temple Graham , Merger Michael , Rustin Gordon 
Published: August 2011

Purpose Inhibiting angiogenesis is one of the most promising avenues for new therapies for ovarian cancer. We investigated the efficacy and safety of a novel agent, BIBF 1120, a triple angiokinase inhibitor, after chemotherapy for relapsed disease. Patients and Methods We conducted a randomized, double-blind, controlled phase II trial in 83 patients who had just completed chemotherapy for relapsed ovarian cancer, with evidence of response, but at high risk of further early recurrence. The patients were randomly assigned to receive maintenance therapy using BIBF 1120 250 mg or placebo, twice per day, continuously for 36 weeks. End points were progression-free survival (PFS), toxicity, and overall survival. Results Thirty-six–week PFS rates were 16.3% and 5.0% in the BIBF 1120 and placebo groups, respectively (hazard ratio, 0.65; 95% CI, 0.42 to 1.02; P = .06). Four patients continued on BIBF 1120, including two patients for another year or more. The proportion of patients with any grade 3 or 4 adverse events was similar between the groups (34.9% for BIBF 1120 v 27.5% for placebo; P = .49; mostly grade 3). However, more patients on BIBF 1120 experienced diarrhea, nausea, or vomiting (mainly grade 1 or 2 and no grade 4). There was a higher rate of grade 3 or 4 hepatotoxicity in patients on BIBF 1120 (51.2%) compared with patients on placebo (7.5%; P < .001), but this was rarely of clinical significance, and patients continued with the trial treatment. A single-level dose reduction to 150 mg was made in 15 patients, all on active drug. Conclusion BIBF 1120 is well tolerated and associated with a potential improvement in PFS. The observed treatment effect is sufficient to justify further study within a large phase III trial.
Molecular Aggregation State and Electrical Properties of Terthiophenes/Imogolite Nanohybrids
Authors: Yah Weng On , Irie Atsushi , Jiravanichanun Nattha , Otsuka Hideyuki , Takahara Atsushi 
Published: August 2011

Abstract
Organic/inorganic nanohybrid materials composed of terthiophenes and imogolite were prepared by means of specific surface interaction between a phosphonic acid group in terthiophene derivatives and aluminol groups on the surface of imogolite. The new materials were investigated by FTIR, UV–vis absorption, fluorescence spectroscopy, TEM observation, nitrogen adsorption–desorption, and I–V measurement. Addition of terthiophene of phosphonic acid derivatives into imogolite brought some changes in absorption and photoluminescence spectra, suggesting the formation of H-type aggregate on imogolite surface. The analysis of UV–vis spectra and nitrogen adsorption–desorption data provided insight into the effect of molecular structure of terthiophenes on the adsorption and aggregation behaviors on the imogolite surface. In addition, a significant enhanced current flow was observed through imogolite film when imogolite was chemisorbed by electron-withdrawing terthiophenes. In contrast, current flow decreased as the electron-donating terthiophene was chemisorbed on imogolite. A possible mechanism for such phenomena is discussed.
Effect of the Crystal Packing and LIESST Effect of a Two-Dimensional Iron(II) Spin-Crossover Complex: [FeII(HLH,Me)2](CF3SO3)2 (HLH,Me: 8-(Imidazol-4-ylmethylideneamino)-2-methylquinoline)
Authors: Hagiwara Hiroaki , Sakaguchi Osamu , Nishi Koshiro , Hashimoto Shingo , Matsumoto Naohide 
Published: August 2011

Abstract
A 2D iron(II) spin-crossover (SCO) complex, [FeII(HLH,Me)2](CF3SO3)2, was synthesized, where HLH,Me: 8-(imidazol-4-ylmethylideneamino)-2-methylquinoline, and its structures and magnetic properties were investigated. The complex [FeII(HLH,Me)2](CF3SO3)2 has no crystal solvent and has structure isomorphous to the complex [FeII(HLH,Me)2](ClO4)2·1.5MeCN, and shows a gradual and reversible one-step SCO between the HS (S = 2) and LS (S = 0) states at T1/2 = 215 K without hysteresis. The T1/2 value is higher than that of corresponding desolvated ClO4− compound, [FeII(HLH,Me)2](ClO4)2, about 35 K, although the spin transition is more gradual than that of ClO4− compound and the hysteresis is absent, which is observed in ClO4− compound. The crystal structures were determined at 296 (HS state) and 100 K (LS state), where the crystal system and space group showed no change between these temperatures. The structures at both temperatures have the same 2D layered structure, which is constructed of both the bifurcated NH···O− hydrogen bonds between two CF3SO3− ions and two neighboring imidazole NH groups of the [FeII(HLH,Me)2]2+ cations and the π–π interactions between the two quinolyl rings of the two adjacent cations. This network structure is the same as that of ClO4− compound. 600 nm light irradiation at 10 K induced the LIESST effect.
Complex Formation of Cyclodextrins with a Dumbbell Molecule Bearing Two Ferrocene Moieties at the Ends
Authors: Yamamoto Takaya , Oi Wataru , Hashidzume Akihito , Harada Akira 
Published: August 2011

Abstract
The complexation behavior of cyclodextrins (CDs) with a dumbbell molecule possessing ferrocene (Fc) moieties at both the ends (FcC10Fc) was investigated by 1H NMR, two-dimensional rotating frame Overhauser spectroscopy, circular dichroism spectroscopy, and cyclic voltammetry. α-CD includes the cyclopentadienyl rings of the Fc moiety shallowly from the wider side but not the decamethylene (C10) moiety, whereas β-CD and γ-CD include not only the Fc moiety but also the C10 moiety. These observations indicate that the Fc moiety can pass through β-CD and γ-CD cavities but not the α-CD cavity.
Pitt's inequality and the fractional Laplacian: Sharp error estimates
Authors: Beckner William 
Published: August 2011

Abstract.
Sharp error estimates in terms of the fractional Laplacian
and a weighted Besov norm are obtained
for Pitt's inequality by using the spectral representation with weights for the
fractional Laplacian due to Frank, Lieb and Seiringer and the sharp
Stein–Weiss inequality. Dilation invariance, group symmetry on a non-unimodular group and a
nonlinear Stein–Weiss lemma are used to provide short proofs of the
Frank–Seiringer “Hardy inequalities” where fractional smoothness is
measured by a Besov norm.
Surface Characterization of Replicate Wood Surfaces for Cleaning Studies
Authors: Lewis Roger D. , Kennedy Jason , Andruskiewicz Mason , Brown Christopher A. , Condoor Sridhar 
Published: August 2011

Abstract
A need exists to develop realistic surfaces, with differing degrees of surface roughness, to standardize methods for sampling and cleaning of environmental contaminants. This study reports on development and characterization of a novel means to create reproducible wood surfaces that are approximately 7 × 10 cm2 and have differing degree of surface roughness. Three unique specimens were prepared by creating 3-dimensional digital-scans of actual wood surfaces found in three St. Louis homes. These surfaces had distinct depressions that likely arose from tool marks. A reverse image die of each specimen was made from high density plastic. Replicates of the three specimens were created by placing a die and wood veneer section into a rolling-press leaving the original topographies gathered from the homes. These specimens were used in a separate study to evaluate cleaning leaded dust using wipe or vacuuming treatments. The separate cleaning studies found no difference in cleaning due to the effects of the different surfaces. An in-depth examination of the three specimens was held to determine if differences in surface roughness of the specimens explained removal of lead from its surface. A method using optical, 3-D laser profilometry was used to determine if there were statistical differences between the surface roughness of the three specimens and within the specimens themselves. Area-scale analyses were made to calculate relative areas as a function of scale as a way of characterizing the roughness. Statistical differences were found for surface roughness between each of three surface specimens at a scale where small particles, deposited in the cleaning studies may adhere to the wood. However, within the specimens, surface roughness, at the scale where fine particles may lodge, were not consistent inside or outside tool marks. Therefore, differences in surface roughness were found within and between surfaces but they may not be large enough or different enough for detection using simple cleaning methods. Specimens with larger differences in surface roughness may be needed to simulate differences in cleaning effectiveness. This work should be continued to understand the scales for the different interactions of particle deposition, adhesion, and removal toward development of standard reference surfaces with well-characterized textures.
Evaluation of a Modified Guar OD Formulation for Spray Drift Mitigation
Authors: Halecky Alan , Roberts Johnnie , Penfield Kevin , Baker Trey 
Published: August 2011

Abstract
Oil dispersions (OD) of spray drift mitigation agents offer ease of incorporation of the agent into the tank mix. An oil dispersion of guar gum has been developed that not only achieves even dispersion of guar into the spray tank but also exhibits good physical stability. The influence of dispersing agents and emulsifiers on spray characteristics, rheology, and physical stability was examined.
Modeling Creep-Fatigue Behavior of Mod.9Cr-1Mo Steel
Authors: Li Meimei , Majumdar S. , Natesan K. 
Published: August 2011

Abstract
This paper presents three models that were developed explicitly for predicting the creep-fatiguebehavior of Mod.9Cr-1Mo steel. The Cyclic Softening Model incorporated tensile strain hardening and creep deformation, and described the cyclic stress variation as a function of cycle number under hold-time creep-fatigue loading. The Stress Relaxation Model predicted the stress relaxation curve during the hold time of cyclic loading, based on the creep properties of the material. The Interactive Damage Rate Equation predicted the hold-time creep-fatigue life using a methodology, in which the key materials parameters were determined by the creep properties and continuous fatigue data. The model predictions captured the trends of creep-fatigue interaction in Mod.9Cr-1Mo steel, and were in good agreement with experimental data in the literature.
Letter to the Editor: Concomitant Off-Pump Coronary Artery Bypass Grafting and Thymectomy
Authors: Shih Yu-Jen , Lin Yi-Chang , Tsai Yi-Ting , Lin Chih-Yuan , Lee Chung-Yi , Yang Hsiang-Yu , Tsai Cheng-Ken , Tsai Chien-Sung 
Published: August 2011

Thymoma in patients with coronary disease is rare. Although simultaneously performing a cardiac procedure and thymectomy for patients with combined thymoma and cardiac disease has been reported, a clear consensus regard- ing the optimal surgical treatment is lacking. Moreover, in all of the previously reported cases, the surgical intervention and standard cardiopulmonary bypass were performed simul- taneously. We present the case of a patient who underwent combined off-pump coronary artery bypass grafting (CABG) and thymectomy. We show that this combined procedure is the treatment of choice for patients with a severely ischemic myocardium and a malignant thymoma.
Written-Language Disorder Among Children With and Without ADHD in a Population-Based Birth Cohort
Authors: Yoshimasu Kouichi , Barbaresi William J. , Colligan Robert C. , Killian Jill M. , Voigt Robert G. , Weaver Amy L. , Katusic Slavica K. 
Published: August 2011

OBJECTIVE:
We determined the incidence of written-language disorder (WLD) among children with and without attention-deficit/hyperactivity disorder (ADHD) in a population-based birth cohort.

METHODS:
Subjects included a birth cohort of all children born in 1976–1982 who remained in Rochester, Minnesota, after 5 years of age (N = 5718). Information from medical, school, and private tutorial records was abstracted. Cumulative incidences of WLD with or without reading disability (RD), identified with any of 3 formulas, among children with and without ADHD and hazard ratios (HRs) were calculated.

RESULTS:
For both genders, the cumulative incidence of WLD by 19 years of age was significantly higher for children with ADHD than for children without ADHD (boys: 64.5% vs 16.5%; girls: 57.0% vs 9.4%). The magnitude of association between ADHD and WLD with RD was significantly higher for girls than for boys (adjusted HR: girls: 9.8; boys: 4.2; P &lt; .001). However, this was not true for WLD without RD (adjusted HR: girls: 7.4; boys: 6.6; P = .64).

CONCLUSIONS:
ADHD is strongly associated with an increased risk of WLD (with or without RD) for both boys and girls. Girls with ADHD are at higher risk of having WLD with RD compared with boys with ADHD, whereas boys and girls are at the same risk of having WLD without RD.
Quality of Reporting of Neonatal and Infant Trials in High-Impact Journals
Authors: DeMauro Sara B. , Giaccone Annie , Kirpalani Haresh , Schmidt Barbara 
Published: August 2011

OBJECTIVES:
To perform a systematic review of the quality of reporting for randomized controlled trials (RCTs) with infants and neonates that were published in high-impact journals and to identify RCT characteristics associated with quality of reporting.

METHODS:
RCTs that enrolled infants younger than 12 months and were published in 2005–2009 in 6 pediatric or general medical journals were reviewed. Eligible RCTs were evaluated for the presence of 11 quality criteria selected from the Consolidated Standards of Reporting Trials guidelines. The relationships between quality of reporting and key study characteristics were tested with nonparametric statistics.

RESULTS:
Two reviewers had very good agreement regarding the eligibility of studies (κ = 0.85) and the presence of quality criteria (κ = 0.82). Among 179 eligible RCTs, reporting of the individual quality criteria varied widely. Only 50% included a flow diagram, but 99% reported the number of study participants. Higher quality of reporting was associated with greater numbers of study participants, publication in a general medical journal, and greater numbers of centers (P &lt; .0001 for each comparison). Geographic region and positive study outcomes were not associated with reporting quality.

CONCLUSIONS:
The quality of reporting of infant and neonatal RCTs is inconsistent, particularly in pediatric journals. Therefore, readers cannot assess accurately the validity of many RCT results. Strict adherence to the Consolidated Standards of Reporting Trials guidelines should lead to improved reporting.
Outcomes of Research Biopsies in Phase I Clinical Trials: The MD Anderson Cancer Center Experience
Authors: El-Osta Hazem , Hong David , Wheler Jennifer , Fu Siqing , Naing Aung , Falchook Gerald , Hicks Marshall , Wen Sijin , Tsimberidou Apostolia M. , Kurzrock Razelle 
Published: August 2011

Abstract

Background.
Research biopsies are crucial for exploring the impact of novel agents on putative targets. The current study assesses the safety and success rate associated with performing such biopsies.

Methods.
We reviewed the medical records of 155 consecutive patients who had one or more research biopsies as part of a phase I trial from September 2004 to October 2009.

Results.
Of 281 research biopsies performed, 118 were paired before and after treatment biopsies (total = 236 biopsies). The most common sites of biopsy were superficial lymph node (19.9%), followed by liver (16.4%), and then soft tissue (15.7%). Ultrasound-guided biopsies were the most frequent type (53.7%). Among 142 patients who consented for mandatory biopsy, 86.6% had the biopsy performed, compared with 4.4% of 911 patients offered a biopsy on an optional basis (p &lt; .0001). Biopsy was obtained most frequently on industry-sponsored trials; lack of funding on nonindustry trials was the most common reason that biopsies were not obtained. Of 281 single biopsies, only 4 (1.4%) had complications: pneumothorax requiring chest tube placement (n = 2), infection requiring admission (n = 1), and arrhythmia with hypotension (n = 1). All but one biopsy was successful in obtaining tissue. No deaths were attributable to biopsy.

Conclusions.
Our experience demonstrates that research biopsies in early phase clinical trials are safe (1.4% risk of serious complications), and a higher percentage of patients underwent mandatory biopsies (86.6%) compared with that of the patients with optional biopsies (4.4%).
Number of Teeth Is Related to Atherosclerotic Plaque in the Carotid Arteries in an Elderly Population
Authors: Holmlund Anders , Lind Lars 
Published: August 2011

Background: Periodontal disease has been associated with cardiovascular disorders with an atherosclerotic background, and number of teeth (NT) has been suggested as a possible risk indicator for cardiovascular disease. The objective of this study is to investigate whether NT was related to the intima‐media thickness (IMT) and to atherosclerotic plaque in carotid arteries in an elderly population.Methods: In a population‐based study including 1,016 participants aged 70 years, the NT was self‐reported by 947 of the participants. Carotid artery IMT was evaluated by ultrasound. The occurrence of plaque was also measured. Logistic regression was used to analyze the associations between NT and the number of carotid arteries with plaque.Results: A significant inverse relationship was found between the NT and the number of carotid arteries with plaque after adjustment for age, sex, smoking, body mass index, waist/hip ratio, blood glucose, triglycerides, cholesterol, C‐reactive protein, leukocyte count, blood pressure, and Framingham risk score, with odds ratio of 0.89, 95% confidence interval of 0.82 to 0.98, and P = 0.016. The relationship was fairly linear, suggesting a dose–response relationship. When NT was divided into quintiles using the first one as referent, the relationship persisted for all quintiles except for the second one. However, no relationship to IMT was seen.Conclusion: The present study further emphasizes that tooth loss could be an easily obtained risk indicator for atherosclerosis.
Association Between Volatile Sulfur Compounds and Periodontal Disease Progression in Elderly Non‐Smokers
Authors: Makino Yuka , Yamaga Takayuki , Yoshihara Akihiro , Nohno Kaname , Miyazaki Hideo 
Published: August 2011

Background: Periodontal pathogenic microorganisms produce volatile sulfur compounds (VSCs), such as hydrogen sulfide, methyl mercaptan, and dimethyl sulfide. VSCs are toxic to periodontal tissue. Therefore, there is a relationship between periodontitis and the VSC level of mouth air. However, the association between VSC and periodontal disease progression has not been investigated in a longitudinal study. The purpose of this study is to evaluate the association between VSCs in mouth air and periodontal disease progression among elderly dentulous non‐smokers.Methods: Two hundred forty‐one dentulous non‐smokers (103 males and 138 females; all 70 years old) had their VSC levels examined with a portable sulfide monitor, and their periodontal status was assessed. Periodontal examinations were performed at baseline and once a year for 3 years to investigate the clinical attachment levels of all teeth. Participants were classified by membership in tertile groups (lowest, middle, and highest) according to the value of baseline VSC measurements.Results: In negative binomial regression analysis, the number of teeth with periodontal disease progression for participants in the highest tertile of VSC measurement was greater (incidence rate ratio of 1.33, P = 0.011) than for the reference group (lowest tertile of VSC measurement) after simultaneously adjusting for sex, number of remaining teeth, and maximum clinical attachment level.Conclusions: VSC measurements were significantly associated with periodontal disease progression in a non‐smoking dentulous elderly population. This suggests that VSC measurements are useful for the diagnosis of periodontal disease progression.
Impact of Assurance and Assurer's Professional Affiliation on Financial Analysts' Assessment of Credibility of Corporate Social Responsibility Information
Authors: Pflugrath Gary , Roebuck Peter , Simnett Roger 
Published: August 2011

SUMMARY
This study reports the results of a behavioral experiment examining whether financial analysts from Australia, the United States, and the United Kingdom perceive a difference in the credibility of stand-alone corporate social responsibility (CSR) reports depending on whether they are assured, and the type of assurance provider (professional accountants versus sustainability consultants). We further examine whether the perceived credibility differs for financial analysts from the different countries and whether results hold for companies from different industries. The overall results show the credibility of a CSR report is greater when it is assured and when the assurer is a professional accountant. While assurance increases the credibility of the information in each of the three countries included, the relative impact is context-specific. Information is perceived to be more credible when a company is from an industry where assurance is more commonplace, and by financial analysts from the United States when the assurer is a professional accountant. Financial analysts from Australia and the United Kingdom perceive little difference in the enhanced credibility provided by the different assurance providers.
Data Availability: Contact the first author about the availability of the data.