bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adherence to surveillance care guidelines after breast and colorectal cancer treatment with curative intent
Authors: Salloum Ramzi G. , Hornbrook Mark C. , Fishman Paul A. , Ritzwoller Debra P. , O'Keeffe Rossetti Maureen C. , Elston Lafata Jennifer 
Published: March 2012

AbstractBACKGROUND:Evidence‐based guidelines recommend routine surveillance, including office visits and testing, to detect new and recurrent disease among survivors of breast and colorectal cancer. The extent to which surveillance practice is consistent with guideline recommendations or may vary by age is not known.METHODS:Cohorts of adult patients diagnosed with breast (n = 6205) and colorectal (n = 2297) cancer between 2000 and 2008 and treated with curative intent in 4 geographically diverse managed care environments were identified via tumor registries. Kaplan‐Meier estimates were used to describe time to initial and subsequent receipt of surveillance services. Cox proportional hazards models evaluated the relation between patient characteristics and receipt of metastatic screening.RESULTS:Within 18 months of treatment, 87.2% of breast cancer survivors received recommended mammograms, with significantly higher rates noted for patients aged 50 years to 65 years. Among survivors of colorectal cancer, only 55.0% received recommended colon examinations, with significantly lower rates for those aged ≥ 75 years. The majority of breast (64.7%) and colorectal (73.3%) cancer survivors received nonrecommended metastatic disease testing. In patients with breast cancer, factors associated with metastatic disease testing include white race (hazards ratio [HR], 1.13), comorbidities (HR, 1.17), and younger age (HR, 1.13; 1.15; 1.13 for age groups: <50, 50–64, and 65–74 respectively). In those with colorectal cancer, these factors included younger age (HR, 1.31; 1.25 for age groups: <50 and 50–64 respectively) and comorbidities (HR, 1.10).CONCLUSIONS:Among an insured population, wide variation regarding the use of surveillance care was found by age and relative to guideline recommendations. Breast cancer survivors were found to have high rates of both guideline‐recommended recurrence testing and non–guideline‐recommended metastatic testing. Only approximately 50% of colorectal cancer survivors received recommended tests but greater than 67% received metastatic testing. Cancer 2012. © 2012 American Cancer Society.
A high‐productivity task‐based programming model for clusters
Authors: Tejedor Enric , Farreras Montse , Grove David , Badia Rosa M. , Almasi Gheorghe , Labarta Jesus 
Published: March 2012

SUMMARYProgramming for large‐scale, multicore‐based architectures requires adequate tools that offer ease of programming and do not hinder application performance. StarSs is a family of parallel programming models based on automatic function‐level parallelism that targets productivity. StarSs deploys a data‐flow model: it analyzes dependencies between tasks and manages their execution, exploiting their concurrency as much as possible.This paper introduces Cluster Superscalar (ClusterSs), a new StarSs member designed to execute on clusters of SMPs (Symmetric Multiprocessors). ClusterSs tasks are asynchronously created and assigned to the available resources with the support of the IBM APGAS runtime, which provides an efficient and portable communication layer based on one‐sided communication.We present the design of ClusterSs on top of APGAS, as well as the programming model and execution runtime for Java applications. Finally, we evaluate the productivity of ClusterSs, both in terms of programmability and performance and compare it to that of the IBM X10 language. Copyright © 2012 John Wiley & Sons, Ltd.
Impact of parasitics on even symmetric split‐capacitor arrays
Authors: Rodríguez‐Pérez Alberto , Delgado‐Restituto Manuel , Medeiro Fernando 
Published: March 2012

ABSTRACTThis paper analyzes the impact of parasitic capacitances in the performance of split capacitive‐based digital‐to‐analog converter arrays and presents a procedure for the optimal sizing of these structures for given linearity specifications. It also demonstrates that parasitics are often the main responsible for the nonlinear behavior of these arrays, particularly for low‐to‐medium resolution converters. In order to validate the analysis, two versions of a complete low‐power, low‐voltage successive‐approximation register analog‐to‐digital converter (ADC), intended for a disposable multi‐channel bio‐medical monitoring system, have been fabricated in a 0.35 µm standard complementary metal‐oxide‐semiconductor technology. The only difference between these two prototypes is that in one of them, the capacitive array is surrounded by dummy capacitors, while in the other prototype is not. Hence, the former achieves better mismatch performance at the expense of increased parasitics. The experimental results demonstrate that the version without dummy capacitors obtains higher effective resolution than the ADC with dummies, the power consumption being essentially the same for both prototypes, namely: 130nW at 2kS/s from a 1‐V supply. These results are in full agreement with the analysis reported in the paper and confirm the proposed sizing procedure. Copyright © 2012 John Wiley & Sons, Ltd.
Development of lead‐free BaTiO3 ceramics possessing enhanced piezoelectric properties
Authors: Takahashi Hirofumi 
Published: March 2012

AbstractDue to recent environmental issues, many research findings on non‐lead‐based materials have appeared. The author also reported the possibility of improvement of piezoelectric materials by microwave (MW) sintering. We checked the relationships between the domain size and piezoelectric constant d33 in BaTiO3 ceramics, and the grain boundary and domain properties of ceramics, which are reported herein. © 2012 Wiley Periodicals, Inc. Electron Comm Jpn, 95(4): 20–26, 2012; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/ecj.10418
Selective killing of p53‐deficient cancer cells by SP600125
Authors: Jemaà Mohamed , Vitale Ilio , Kepp Oliver , Berardinelli Francesco , Galluzzi Lorenzo , Senovilla Laura , Mariño Guillermo , Malik Shoaib Ahmad , Rello‐Varona Santiago , Lissa Delphine , Antoccia Antonio , Tailler Maximilien , Schlemmer Frederic , Harper Francis , Pierron Gérard , Castedo Maria , Kroemer Guido 
Published: March 2012

AbstractThe genetic or functional inactivation of p53 is highly prevalent in human cancers. Using high‐content videomicroscopy based on fluorescent TP53+/+ and TP53−/− human colon carcinoma cells, we discovered that SP600125, a broad‐spectrum serine/threonine kinase inhibitor, kills p53‐deficient cells more efficiently than their p53‐proficient counterparts, in vitro. Similar observations were obtained in vivo, in mice carrying p53‐deficient and ‐proficient human xenografts. Such a preferential cytotoxicity could be attributed to the failure of p53‐deficient cells to undergo cell cycle arrest in response to SP600125. TP53−/− (but not TP53+/+) cells treated with SP600125 became polyploid upon mitotic abortion and progressively succumbed to mitochondrial apoptosis. The expression of an SP600125‐resistant variant of the mitotic kinase MPS1 in TP53−/− cells reduced SP600125‐induced polyploidization. Thus, by targeting MPS1, SP600125 triggers a polyploidization program that cannot be sustained by TP53−/− cells, resulting in the activation of mitotic catastrophe, an oncosuppressive mechanism for the eradication of mitosis‐incompetent cells.
MRT letter: Extended depth from focus reconstruction method for stretch zone measurement in 15‐5PH steel
Authors: De Oliveira Caltabiano Pietro Carelli Reis , Rosa Paulo Henrique Santos , De Campos Kamila Amato , De Oliveira Hein Luis Rogerio 
Published: March 2012

AbstractThe stretch zone width (SZW) data for 15‐5PH steel CTOD specimens fractured at −150°C to + 23°C temperature were measured based on focused images and 3D maps obtained by extended depth‐of‐field reconstruction from light microscopy (LM) image stacks. This LM‐based method, with a larger lateral resolution, seems to be as effective for quantitative analysis of SZW as scanning electron microscopy (SEM) or confocal scanning laser microscopy (CSLM), permitting to clearly identify stretch zone boundaries. Despite the worst sharpness of focused images, a robust linear correlation was established to fracture toughness (KC) and SZW data for the 15‐5PH steel tested specimens, measured at their center region. The method is an alternative to evaluate the boundaries of stretched zones, at a lower cost of implementation and training, since topographic data from elevation maps can be associated with reconstructed image, which summarizes the original contrast and brightness information. Finally, the extended depth‐of‐field method is presented here as a valuable tool for failure analysis, as a cheaper alternative to investigate rough surfaces or fracture, compared to scanning electron or confocal light microscopes. Microsc. Res. Tech. 75:1155–1158, 2012. © 2012 Wiley Periodicals, Inc.
Treatment with ginseng total saponins reduces the secondary brain injury in rat after cortical impact
Authors: Xia Lei , Jiang Zheng‐Lin , Wang Guo‐Hua , Hu Bao‐Yin , Ke Kai‐Fu 
Published: March 2012

AbstractThe present study was designed to investigate the neuroprotective effect of ginseng total saponins (GTSs) and its underlying mechanisms in a rat model of traumatic brain injury (TBI). Rats were injected with GTSs (20 mg/kg, i.p.) or vehicle for 14 days after TBI. Neurological functions were determined using beam balance and prehensile traction tests at 1–14 days after trauma. Brain samples were extracted at 1 day after trauma for determination of water content, Nissl staining, enzyme‐linked immunosorbent assay, immunohistochemistry, terminal deoxynucleotidyl transferase‐mediated biotin‐dUTP nick end labeling, and measurement of oxidative stress variables and inflammatory cytokines. Moreover, the dose response of the neuroprotective effect and time window of the efficacy of GTSs were also determined. We found that treatment of GTSs 1) improved the neurological function with an effective dosage of 5–80 mg/kg and an efficacy time window of 3–6 hr after TBI; 2) reduced brain water content and neuronal loss in the hippocampal CA3 area; 3) increased the activity of superoxide dismutase and decreased the activity of nitric oxide synthase and the amount of malondialdehyde and nitric oxide; 4) down‐regulated interleukin‐1β, interleukin‐6, and tumor necrosis factor‐α and upregulated interleukin‐10 in the cortical area surrounding the injured core; and 5) inhibited the apoptotic cell death and expression of caspase‐3 and bax and raised the expression of bcl‐2. These findings suggest that administration of GTSs after TBI could reduce the secondary injury through inhibiting oxidative and nitrative stress, attenuating inflammatory response, and reducing apoptotic cell death. © 2012 Wiley Periodicals, Inc.
The nomenclature of venous flow‐through flaps: Updated classification and review of the literature
Authors: Goldschlager Romi , Rozen Warren M. , Ting Jeannette W.C. , Leong James 
Published: March 2012

AbstractVenous flow‐through flaps (venous flaps) are useful reconstructive options, particularly in the repair of defects with segmental vessel loss. They are relatively easy to harvest and confer several benefits at the donor site. However, given that they are based on a single central vein, their survival is notoriously unreliable and they are susceptible to ischemia and venous congestion. Various designs have been suggested to improve the circulatory physiology, and hence survival, of venous flap. More recent designs involve adaptations to the arrangement and number of efferent veins draining arterialized venous flaps. The most commonly used classification system for venous flaps, proposed by Chen, Tang, and Noordhoff, does not afford adequate description of these alternate designs. This article offers a classification system that can incorporate all reported modifications to venous flaps. This simple adaptation to the classification system proposed by Chen et al. restores its usefulness in describing modern variations to venous flap design. © 2012 Wiley Periodicals, Inc. Microsurgery, 2012.
The long‐term functional recovery of repair of sciatic nerve transection with biogenic conduits
Authors: Penna Vincenzo , Wewetzer Konstantin , Munder Beatrix , Stark G. Bjoern , Lang Eva M. 
Published: March 2012

AbstractIntroduction:The aim of this study was to evaluate long‐term regenerative capacity over a 15‐mm nerve gap of an autologous nerve conduit, the biogenic conduit (BC), 16 weeks after sciatic nerve transection in the rat.Methods:A 19‐mm long polyvinyl chloride (PVC) tube was implanted parallely to the sciatic nerve. After implantation, a connective tissue cover developed around the PVC‐tube, the so‐called BC. After removal of the PVC‐tube the BCs filled with fibrin (n = 8) were compared to autologous nerve grafts (n = 8). Sciatic functional index (SFI) was evaluated every 4 weeks, histological evaluation was performed at 16 weeks postimplantation. Regenerating axons were visualized by retrograde labelling.Results:SFI revealed no significant differences. Nerve area and axon number in the BC group were significantly lower than in the autologous nerve group (P < 0.05; P < 0.01). Analysis of myelin formation showed no significant difference in both groups. Analysis of N‐ratio revealed lower values in the BC group (P < 0.001).Conclusion:This study reveals the suitability of BC for nerve gap bridging over a period of 16 weeks with functional recovery to comparable extent as the autologous nerve graft despite impaired histomorphometric parameters. © 2012 Wiley Periodicals, Inc. Microsurgery, 2012.
Characterization and thermal‐oxidative degradation behavior of poly(ethylene terephthalate‐co‐4,4′‐bibenzoate) prepared via direct esterification technique
Authors: Dai Junming , Li Guang , Yang Shenglin , Jiang Jianming 
Published: March 2012

AbstractA series of poly(ethylene terephthalate‐co‐4,4′‐bibenzoate)s (PETBBs) were prepared via direct esterification from the monomers of terephthalic acid (TPA), 4,4′‐biphenyl dicarboxylic acid (BPDA), and ethylene glycol (EG) with different molar ratios. The chemical compositions of the obtained PETBBs, investigated by H1‐NMR, were identical with the feed ratio, and the high molecular weights of PETBBs were confirmed by GPC analysis. The glass transition, crystallization, and melting behavior of them were measured by DSC; the results indicated that, in the range of 5–25 mol% of BPDA addition, the glass transition temperature (Tg) increased almost linearly and the melting temperature (Tm) decreased with increasing content of BPDA unit. As expected, the crystallization of PETBB became difficult with increasing introduction of BPDA, explained by higher crystallization temperature and smaller crystallization enthalpy from the glassy state. This decrease of crystallization rate may be beneficial to film processing. Moreover, owing to the introduction of rigid‐rod BPDA unit, the initial and maximum thermal‐oxidative decomposition temperatures were enhanced. The kinetic analysis of the thermal‐oxidative degradation indicated that the apparent activation energies of degradation for these PETBBs became higher than that of PET. POLYM. ENG. SCI., 2012. © 2012 Society of Plastics Engineers
Rheological behavior of polypropylene nanocomposites at low concentration of surface modified carbon nanotubes
Authors: Thomas Selvin P. , Girei Salihu Adamu , Atieh Muataz Ali , De S.K. , Al‐Juhani Abdulhadi 
Published: March 2012

AbstractThis article reports the rheological behavior of nanocomposites of isotactic polypropylene with both unmodified multiwall carbon nanotubes (CNTs) and phenol and 1‐octadecanol (C18) functionalized CNT (f‐CNT) at 0.1, 0.25, 1.0, and 5.0 wt% of the nanofillers. The incorporation of CNT at low loadings of 0.1 and 0.25 wt% decreases the storage and loss modulus and complex viscosity of the system, especially for the case of using f‐CNT. Out of the two types of functionalizations, C18 functionalization registers the lowest modulus and viscosity and displays processing aid behavior at 0.1 wt% loading, which is believed to be due to the disruption of the polymer entanglements. As the nanofiller loading increases to 1 wt%, the disruption of polymer entanglements effect is balanced by the hydrodynamic effect and subsequently neat polypropylene (PP), and the filled PP systems show similar modulus and complex viscosity. As the nanofiller loading increases further to 5 wt%, the hydrodynamic effect becomes the dominating factor, and the modulus and the complex viscosity of the nanofilled system become greater than that of neat PP. Results suggest that the 0.1 wt% loading of C18 f‐CNT could be a useful processing aid additive for improving polypropylene processability. POLYM. ENG. SCI., 52:1868–1873, 2012. © 2012 Society of Plastics Engineers
Enhanced fatigue life of carbon nanotube‐reinforced epoxy composites
Authors: Loos M.R. , Yang J. , Feke D.L. , Manas‐Zloczower I. 
Published: March 2012

AbstractThe effects of carbon nanotube (CNT) inclusion on cyclic fatigue behavior and the residual mechanical properties of epoxy composites after different degrees of fatigue have been studied. Tension–tension cyclic fatigue tests were conducted at various load levels (25–50 MPa) to establish the relationship between stress and the number of cycles to failure (S–N curves). The residual strength and modulus were measured after loading at 30 MPa for 5000, 15,000, and 25,000 cycles. The incorporation of a small amount of CNTs increased the fatigue life of epoxy in the high‐cycle, low‐stress‐amplitude regime by 1550%. Micrographs indicate the key mechanisms for enhancement in fatigue life such as CNT crack‐bridging and pullout. POLYM. ENG. SCI., 52:1882–1887, 2012. © 2012 Society of Plastics Engineers
Geolocation‐aware security in a netcentric small unmanned‐aerial‐system for RF emitters
Authors: Liang Jing 
Published: March 2012

AbstractEnhancing security requires sensing devices surveilling over critical infrastructures for early warning of radio frequency (RF) emitter geolocations. Conventional geolocation of RF emitters has adopted active methodologies by illuminating targets, such as radar sensors. However, active geolocation draws unwanted attention of adversary, thus highly increases threats and vulnerabilities of the sensing devices. As security issues become a central concern in sensing applications, we propose a small unmanned‐aerial‐system for passive geolocation of RF emitters. Multiple electronic surveillance sensors are mounted on small unmanned‐aerial‐vehicles (UAVs) to provide geolocation awareness. Both sensors‐to‐UAV and UAVs‐to‐fusion‐center communications are investigated. Different with previous studies, our approach is based on an empirical path loss and log‐normal shadowing model, from a wireless communication and signal processing vision. The communication degradation from UAV to fusion center has been taken into consideration other than assuming lossless performance. The analyzed geolocation error and the error probability of distance shows that this approach provides robust performance at high frequencies, thus offers an effective solution for the security issue in RF emitter geolocation. Copyright © 2012 John Wiley & Sons, Ltd.
Comparison of multicast/broadcast services in Long Term Evolution Advanced and IEEE 802.16m networks
Authors: Calabuig Jorge , Monserrat Jose F. , Martín‐Sacristán David , Olmos Joan 
Published: March 2012

ABSTRACTThis paper performs a comparison of multicast/broadcast services (MBS) support in Long Term Evolution Advanced (LTE‐A) and Worldwide Interoperability for Microwave Access (WiMAX) IEEE 802.16m. Firstly, the main technical features of both standards concerning MBS operation are presented. It is shown that WiMAX offers higher unicast/MBS multiplexing flexibility as it supports both frequency and time multiplexing schemes, whereas LTE‐A only includes time multiplexing. Besides, only WiMAX supports multi‐antenna transmission. Next, the results of two simulation‐based assessments are presented. In the former, it is considered a scenario with all cells transmitting the same MBS service. The effect of inter‐site distance (ISD) on the maximum MBS data rate is evaluated. Results show that WiMAX configurations outperform LTE‐A for small ISD. This is because WiMAX provides a higher number of resources dedicated to data transmission for the same bandwidth. Furthermore, some WiMAX configurations support two spatially multiplexed data streams. With higher ISDs, LTE‐A outperforms single‐stream WiMAX configurations. In the second assessment, a MBSFN area surrounded by interfering cells is considered to compare unicast/MBS multiplexing performance. The higher maximum MBS data rate is achieved in WiMAX with time division multiplexing, which is precisely the only alternative included in LTE‐A. Copyright © 2012 John Wiley & Sons, Ltd.
Towards a precise lattice determination of the leading hadronic contribution to (g − 2)
μ
Authors: Morte Michele Della , Jäger Benjamin , Jüttner Andreas , Wittig Hartmut 
Published: March 2012

Abstract

We report on our computation of the leading hadronic contribution to the anomalous magnetic moment of the muon using two dynamical flavours of non-perturbatively O(a) improved Wilson fermions. The strange quark is introduced in the quenched approximation. Partially twisted boundary conditions are applied to improve the momentum resolution in the relevant integral. Our results, obtained at three different values of the lattice spacing, allow for a preliminary study of discretization effects. We explore a wide range of lattice volumes, namely 2 fm ≤ L ≤ 3 fm, with pion masses from 600 to 280 MeV and discuss different chiral extrapolations to the physical point. We observe a non-trivial dependence of
$a_\mu^{HLO}$
on m

π
especially for small pion masses. The final result,
$a_\mu^{HLO} = 618\left( {64} \right) \times {10^{ - 10}}$
, is obtained by considering only the quark connected contribution to the vacuum polarization. We present a detailed analysis of systematic errors and discuss how they can be reduced in future simulations.
‘To regulate and confirm inequality’? A regional history of geriatric hospitals under the English National Health Service,c.1948–c.1975
Authors: GORSKY MARTIN 
Published: March 2012

ABSTRACTThe post-war history of hospital care for older people in Britain in the first phase of its National Health Service (NHS) emphasises a detrimental Poor Law legacy. This article presents a regional study, based on the South West of England, of the processes by which Victorian workhouses became the basis of geriatric hospital provision under the NHS. Its premise is that legislative and medical developments provided opportunities for local actors to discard the ‘legacy’, and their limited success in doing so requires explanation. Theoretical perspectives from the literature are introduced including political economy approaches; historical sociology of the medical profession; and path dependence. Analysis of resource allocation decisions shows a persistent tendency to disadvantage these institutions by comparison with acute care hospitals and services for mothers and children, although new ideas about geriatric medicine had some impact locally. Quantitative and qualitative data are used to examine policies towards organisation, staffing and infrastructural improvements, suggesting early momentum was not maintained. Explanations lie partly with national financial constraints and partly with the regional administrative arrangements following the NHS settlement which perpetuated existing divisions between agencies.