bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards disposable sensors for drug quality control: Dextromethorphan screen‐ printed electrodes
Authors: Khaled Elmorsy , Hassan H. N. A. , Mohamed Gehad G. , Seleim Aly Eldin A. 
Published: September 2010

AbstractA simple, rapid, reliable, and reproducible method for mass production of disposable sensors using screen‐printing technology is described. Homemade printing has been characterized and optimized on the basis of effects of the modifier and plasticizers. The fabricated bi‐electrode potentiometric strip containing both working and reference electrode was used as dextromethorphan (DXM) sensor. The proposed sensors worked satisfactorily in the concentration range from 10−5 to 10−2 mol L−1 with detection limit reaching 6 × 10−6 mol L−1 and adequate shelf life of 8 months. DXM was determined in pharmaceutical formulations under batch and flow injection analysis (FIA) conditions with sampling output 120 h−1. Copyright © 2010 John Wiley & Sons, Ltd.
Novel antioxidants in food quality preservation and health promotion
Authors: Shahidi Fereidoon , Zhong Ying 
Published: September 2010

AbstractAutoxidation in food and biological systems is responsible for a multitude of adverse effects and implications in human health as well as in food stability and preservation. Antioxidants play a major role in preventing or delaying autoxidation and have attracted much attention as food stabilizers, dietary supplements and natural health products. Both synthetic and natural antioxidants are widely used in food products and an ever increasing number of research papers have appeared in the recent literature on the discovery and application of natural antioxidants and their therapeutic use in inhibiting a myriad of diseases. However, some common synthetic antioxidants have also become controversial due to their potential adverse effects on health. This overview provides the latest developments about novel antioxidants, particularly phenolic derivatives, peptides/protein hydrolysates, phospholipids and polysaccharides, and their role in food quality preservation and human health promotion.
Synthesis and Post‐Resolution Modification of New Axially Chiral Ligands for Asymmetric Catalysis
Authors: Fleming William J. , Müller‐Bunz Helge , Guiry Patrick J. 
Published: September 2010

AbstractThe synthesis of four new members of the Quinazolinap series of ligands is described. Three of these ligands were prepared by post‐resolution modification of the known ligand (R)‐7‐chloro‐2‐isopropyl‐Quinazolinap, a new approach which offers an expedient route to a range of enantiopure ligands as it precludes the need for resolution of each ligand prepared. The remaining ligand, 7‐chloro‐2‐methyl‐Quinazolinap, was prepared in a seven‐step synthetic sequence incorporating palladium‐ and nickel‐catalyzed transformations as the key steps. A diastereomerically pure palladacycle of this ligand was characterised by X‐ray crystallography. (R)‐7‐Chloro‐2‐isopropyl‐Quinazolinap was applied to the rhodium‐catalyzed hydroboration of vinylarenes with regioselectivities of up to > 99:1 and ee values of up to 68 %. Each of the Quinazolinap ligands prepared were applied to the palladium‐catalyzed allylic alkylation of 1,3‐diphenylprop‐2‐enyl acetate resulting in conversions of up to 100 % and ee values of up to 85 %. Solution‐phase NMR studies on a palladium complex of one of the ligands provided a rationale for the sense of asymmetric induction.
A Combined Experimental and Theoretical Study of Anion–π Interactions in N6‐ and N9‐Decyladenine Salts (Eur. J. Org. Chem. 27/2010)
Authors: Garcia‐Raso Angel , Albertí Francisca M. , Fiol Juan J. , Lagos Yolanda , Torres Marta , Molins Elies , Mata Ignasi , Estarellas Carolina , Frontera Antonio , Quiñonero David , Deyà Pere M. 
Published: September 2010

AbstractThe cover picture shows the interesting anion–π/π–π/anion–π assembly that is found in the solid‐state architecture of an adenine derivative hydrochloride salt. The adenine has been decorated with a long alkyl chain (C10) in order to have a predefined ordering in the crystal due to hydrophobic effects. The influence of anion–π and π–π interactions on the final structure has been studied both experimentally and theoretically. Details are discussed in the article by A. Garcia‐Raso et al. on p. 5171 ff. The background picture depicts the scientific tradition of the Balearic Islands that springs from Ramon Llull, a 13th century philosopher, who founded a college in Miramar that is located in the northwest of the island of Majorca.
Hierarchical dynamic modeling of outbreaks of mountain pine beetle using partial differential equations
Authors: Zheng Yanbing , Aukema Brian H. 
Published: September 2010

AbstractIn this article, we develop spatial—temporal generalized linear mixed models for spatial—temporal binary data observed on a spatial lattice and repeatedly over discrete time points. To account for spatial and temporal dependence, we introduce a spatial—temporal random effect in the link function and model by a diffusion—convection dynamic model. We propose a Bayesian hierarchical model for statistical inference and devise Markov chain Monte Carlo algorithms for computation. We illustrate the methodology by an example of outbreaks of mountain pine beetle on the Chilcotin Plateau of British Columbia, Canada. We examine the effect of environmental factors while accounting for the potential spatial and temporal dependence. Copyright © 2010 John Wiley & Sons, Ltd.
On the voice‐data integration in third generation wireless access communication networks
Authors: Paterakis Michael , Cleary Allan C. 
Published: September 2010

AbstractMobile wireless communications, which includes cellular telephones, land mobile radio, and personal communication systems, have experienced enormous growth over the last decade. Data services represent a critical component of future wireless communications, but have received little attention. While some attention has been given to specialized mobile data networks, less has been directed at the ongoing design of data services in evolving digital cellular networks. In this paper we report on the results of a simulation study which explores voice‐data integration performance in third generation wireless communication networks. These networks are designed to provide access to broadband ISDN networks for large numbers of mobile voice and data users. The primary goal of the paper is the development of multiple access transmission protocols that will enable the voice and data terminals to efficiently share the terminal to base station wireless channel. Reservation Random Access (RRA) protocols are used for voice traffic, and multiple random access contention protocols are used for data traffic. The RRA protocols used enable the data terminals to precisely determine the end of voice packet contention periods, therefore providing a natural separation between voice and data contention. Such voice data integration mechanisms allow the voice contending terminals to resolve their contention without any interference from the data terminals. Data contention resolution does not degrade the voice performance, since it follows the voice contention resolution. The above approach is a promising alternative to other existing proposals due to its superior data packet throughput‐delay performance under steady state, and voice performance under transient conditions. Our results show that dispersed voice and data terminals can efficiently share a wireless channel.
Letter: Application of a simplified fano metric to adaptive receivers for digital mobile radio systems
Authors: Zimmermann Gerd , Rupprecht Werner 
Published: September 2010

AbstractThe detection list of sequential detection algorithms like the Generalized‐Stack‐Algorithm normally includes paths with different search lengths. Therefore, a special metric, the socalled Fano metric, has to be used to allow a comparison between the path metrics. A drawback of the Fano metric is its great computational effort in the case of a time‐variant channel impulse response which occurs typically at data transmission over frequency‐selective mobile radio channels. In this paper the most expensive part of the metric is replaced by a bias depending on the instantaneous signal‐to‐noise ratio and the phase characteristic of the channel. Simulation results obtained for the GSM system show the good performance of this method in view of bit error rate and computational complexity relative to the optimum Viterbi‐Algorithm.
Performance of LSF vector quantizers for VSELP coders in noisy channels
Authors: Dall'Agnol Sonia L. Q. , Alcaim Abraham , de Marca José Roberto B. 
Published: September 2010

AbstractEfficient quantization of synthesis filter coefficients for CELP (Code Excited Linear Prediction) coders is essential to achieve high quality speech at low rates. Three vector quantizers with good potential for utilization in low rate coders are studied. Each of them is implemented inside the structure of the VSELP (Vector Sum Excited Linear Prediction) coder, an important member in the class of CELP coders. These three vector quantizers are used to encode LSF (Line Spectral Frequency) parameters and are compared in terms of robustness to channel errors, complexity and quality of synthesized speech. Performance of synthesized speech is evaluated considering the objective measure of frequency weighted signal to noise ratio and subjective results obtained from listening tests. With the purpose of improving the robustness to channel errors, the application of simulated annealing to assign binary indices to the output levels of the quantizer is also investigated. A split vector quantization scheme which employs interframe prediction has shown to be an attractive approach to encode the synthesis filter parameters. It provides a performance comparable to the IS‐54 scheme and uses 10 bits less for each LSF frame.
On encoding pitch and LPC parameters for low‐rate speech coders
Authors: Copperi Maurizio 
Published: September 2010

AbstractThis paper describes the development of efficient methods to encode the parameters of long‐term (pitch) and short‐term (LPC all‐pole) prediction filters with a limited bit‐rate, such that the design of high quality speech coders in the 3–4 kbit/s range becomes easier. Our results indicate that good performance can be reached with about 800 bit/s to represent both the pitch lags and the coefficients of a three‐tap pitch filter, thus achieving a significant 36% bit‐rate reduction in comparison with conventional quantization techniques, and using 24 bit/frame to encode spectral parameters relative to amultilanguagespeech database.
Letter: Cycle slip statistics of a first‐order phase‐locked loop in the presence of additive noise and cochannel interference
Authors: Hasan Pavel 
Published: September 2010

AbstractNumerical results on the mean cycle slip rate of a first‐order phase‐locked loop due to additive Gaussian noise and cochannel CW interference reported in [1] are corrected. In addition, the mean first slip time is given under the same situation. It is shown that both the mean cycle slip rate and the mean first slip time increase with growing I/S ratio. The analysis is supported by extensive computer simulation.
Explicit characteristic‐based finite volume element method for level set equation
Authors: Phongthanapanich Sutthisak , Dechaumphai Pramote 
Published: September 2010

AbstractAccurate modeling of interfacial flows requires a realistic representation of interface topology. To reduce the computational effort from the complexity of the interface topological changes, the level set method is widely used for solving two‐phase flow problems. This paper presents an explicit characteristic‐based finite volume element method for solving the two‐dimensional level set equation. The method is applicable for the case of non‐divergence‐free velocity field. Accuracy and performance of the proposed method are evaluated via test cases with prescribed velocity fields on structured grids. By given a velocity field, the motion of interface in the normal direction and the mean curvature, examples are presented to demonstrate the performance of the proposed method for calculating interface evolutions in time. Copyright © 2010 John Wiley & Sons, Ltd.
Study of the Crystal Structure, Thermal Stability and Conductivity of Sr(V0.5Mo0.5)O3+δ as SOFC Material
Authors: Aguadero A. , de la Calle C. , Pérez‐Coll D. , Alonso J. A. 
Published: September 2010

AbstractThe Sr(V0.5Mo0.5)O3 perovskite has been prepared and characterised and its stability under oxidising and reducing conditions has been tested in order to evaluate its potential use as anode in solid oxide fuel cells (SOFC). The crystal structure of Sr(V0.5Mo0.5)O3 (reduced phase) has been refined, by neutron powder diffraction, in the cubic Pm‐3m space group. The studied material possesses electrical conductivity values above 280 S cm–1 in the studied temperature range (25–900 °C) and displays a thermal expansion coefficient of 12.6 × 10–6 K–1. When the sample is heated above 500 °C in air it is oxidised to a tetragonal Sr(V0.5Mo0.5)O3.7 scheelite phase (space group I41/a). This transition is totally reversible and it is expected not to lead to cracking problems during the cell operation due to the similarity of the expansion coefficients of the reduced and the oxygenated samples, and compatible with the rest of the usual components of an SOFC.
YAP1 and VGLL3, encoding two cofactors of TEAD transcription factors, are amplified and overexpressed in a subset of soft tissue sarcomas
Authors: Hélias‐Rodzewicz Zofia , Pérot Gaëlle , Chibon Frédéric , Ferreira Céline , Lagarde Pauline , Terrier Philippe , Coindre Jean‐Michel , Aurias Alain 
Published: September 2010

AbstractIn a series of 404 adult soft tissue sarcomas, analyzed by array‐CGH, we have observed in approximately 10% of them a genomic amplification of either chromosome bands 11q22 or 3p12. These two amplicons likely target the YAP1 and VGLL3 genes, respectively. Both genes encode proteins that are cofactors of the TEAD family of transcription factors. Very good correlations between amplification and expression levels were observed. Welch test analyses of transcriptome data demonstrate that tumors with amplicons share a large set of upregulated and downregulated genes. Inhibition of YAP1 and VGLL3 in cell lines with these amplifications/overexpressions leads to similar phenotypes: decrease of proliferation rate, and to a lesser extent decrease of migration properties. These data, and the fact that these amplicons are observed either in dedifferentited liposarcomas or in undifferentiated pleomorphic sarcomas, suggest that these genetics events could be involved in oncogenesis and progression of soft tissue sarcomas. © 2010 Wiley‐Liss, Inc.
Variants in folate pathway genes as modulators of genetic instability and lung cancer risk
Authors: Piskac‐Collier Amanda L. , Monroy Claudia , Lopez Mirtha S. , Cortes Andrea , Etzel Carol J. , Greisinger Anthony J. , Spitz Margaret R. , El‐Zein Randa A. 
Published: September 2010

AbstractGenetic instability plays a crucial role in cancer development. The genetic stability of the cell as well as DNA methylation status could be modulated by folate levels. Several studies suggested associations between polymorphisms in folate genes and alterations in protein expression and variations in serum levels of the folate. The objective of this study was to investigate the effect of folate pathway polymorphisms on modulating genetic instability and lung cancer risk. Genotyping of 5 SNPs in folate pathway genes and cytokinesis‐blocked micronucleus cytome assay analysis (to determine the genetic instability at baseline and following NNK treatment) was conducted on 180 lung cancer cases and 180 age‐, gender‐, and smoking‐matched controls. Our results showed that individually, folate pathway SNPs were not associated with cytogenetic damage or lung cancer risk. However, in a polygenic disease such as lung cancer, gene–gene interactions are expected to play an important role in determining the phenotypic variability of the diseases. We observed that interactions between MTHFR677, MTHFR1298, and SHMT polymorphisms may have a significant impact on genetic instability in lung cancer patients. With regard to cytogenetic alterations, our results showed that lymphocytes from lung cancer patients exposed to the tobacco‐specific carcinogen 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone [NNK] had considerably increased frequency of cytogenetic damage in presence of MTHFR 677, MTHFR 1298, and SHMT allelic variants. These findings support the notion that significant interactions may potentially modulate the lung cancer susceptibility and alter the overall the repair abilities of lung cancer patients when exposed to tobacco carcinogens such as NNK. © 2010 Wiley‐Liss, Inc.
Risk prediction using genome‐wide association studies
Authors: Kooperberg Charles , LeBlanc Michael , Obenchain Valerie 
Published: September 2010

AbstractOver the last few years, many new genetic associations have been identified by genome‐wide association studies (GWAS). There are potentially many uses of these identified variants: a better understanding of disease etiology, personalized medicine, new leads for studying underlying biology, and risk prediction. Recently, there has been some skepticism regarding the prospects of risk prediction using GWAS, primarily motivated by the fact that individual effect sizes of variants associated with the phenotype are mostly small. However, there have also been arguments that many disease‐associated variants have not yet been identified; hence, prospects for risk prediction may improve if more variants are included. From a risk prediction perspective, it is reasonable to average a larger number of predictors, of which some may have (limited) predictive power, and some actually may be noise. The idea being that when added together, the combined small signals results in a signal that is stronger than the noise from the unrelated predictors. We examine various aspects of the construction of models for the estimation of disease probability. We compare different methods to construct such models, to examine how implementation of cross‐validation may influence results, and to examine which single nucleotide polymorphisms (SNPs) are most useful for prediction. We carry out our investigation on GWAS of the Welcome Trust Case Control Consortium. For Crohn's disease, we confirm our results on another GWAS. Our results suggest that utilizing a larger number of SNPs than those which reach genome‐wide significance, for example using the lasso, improves the construction of risk prediction models.Genet. Epidemiol. 34: 643‐652, 2010. © 2010 Wiley‐Liss, Inc.
Pathway‐based analysis for genome‐wide association studies using supervised principal components
Authors: Chen Xi , Wang Lily , Hu Bo , Guo Mingsheng , Barnard John , Zhu Xiaofeng 
Published: September 2010

AbstractMany complex diseases are influenced by genetic variations in multiple genes, each with only a small marginal effect on disease susceptibility. Pathway analysis, which identifies biological pathways associated with disease outcome, has become increasingly popular for genome‐wide association studies (GWAS). In addition to combining weak signals from a number of SNPs in the same pathway, results from pathway analysis also shed light on the biological processes underlying disease. We propose a new pathway‐based analysis method for GWAS, the supervised principal component analysis (SPCA) model. In the proposed SPCA model, a selected subset of SNPs most associated with disease outcome is used to estimate the latent variable for a pathway. The estimated latent variable for each pathway is an optimal linear combination of a selected subset of SNPs; therefore, the proposed SPCA model provides the ability to borrow strength across the SNPs in a pathway. In addition to identifying pathways associated with disease outcome, SPCA also carries out additional within‐category selection to identify the most important SNPs within each gene set. The proposed model operates in a well‐established statistical framework and can handle design information such as covariate adjustment and matching information in GWAS. We compare the proposed method with currently available methods using data with realistic linkage disequilibrium structures, and we illustrate the SPCA method using the Wellcome Trust Case‐Control Consortium Crohn Disease (CD) data set. Genet. Epidemiol. 34: 716‐724, 2010. © 2010 Wiley‐Liss, Inc.
When Hong Kong becomes SAR, is the mainland ready? Problems of judgments recognition in cross‐border insolvency matters
Authors: Gong Xinyi 
Published: September 2010

AbstractAfter Hong Kong's handover in the year 1997 to the People's Republic of China (PRC), two judicial systems began to operate in parallel in one country. To date, judicial convergence in cross‐border insolvency matters has not yet been established between the mainland and the Hong Kong Special Administrative Region (HKSAR). By reviewing several recent court decisions, this article demonstrates some problems of judgment recognition in matters of cross‐border insolvency between the two regions. Copyright © 2010 John Wiley & Sons, Ltd.
Cover Picture: Rational Design of Multifunctional Polymer Therapeutics for Cancer Theranostics (Isr. J. Chem. 2/2010)
Authors: Ofek Paula , Miller Keren , Eldar‐Boock Anat , Polyak Dina , Segal Ehud , Satchi‐Fainaro Ronit 
Published: September 2010

AbstractThe cover picture shows the extravasation of polymer therapeutics from angiogenic hyperpermeable vessels and their accumulation in a diseased target site, enabled by the Enhanced Permeability and Retention (EPR) phenomenon. The multivalency of polymers, highlighted in this stylized representation, is what makes possible their ability to be conjugated with drug combinations, a targeting moiety, and a detection probe. The figure was designed by Ehud Segal and Ronit Satchi‐Fainaro and illustrated by Yaara Segal (see Rational Design of Multifunctional Polymer Therapeutics for Cancer Theranostics, R. Satchi‐Fainaro et al., p. 185 in this issue).magnified image