bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolving Patterns of Initial RRMS Treatment in Finland (2013–2022): Insights From a Nationwide Multiple Sclerosis Register
Authors: Ahvenjärvi Henrik , Jokinen Elina , Viitala Matias , Autio Henri , Portaankorva Anne M. , Soilu‐Hänninen Merja , Krüger Johanna , Ryytty Mervi 
Published: February 2025

ABSTRACTBackgroundThe treatment of relapsing‐remitting multiple sclerosis (RRMS) is changing. There are limited data about initial treatment of RRMS in Finland.ObjectiveOur objectives were to study the trends of initial disease‐modifying treatments (DMTs) for patients with RRMS from 2013 to 2022, treatment delays, factors associated with DMT choice, DMT switch patterns, and the effect of the COVID‐19 pandemic.MethodsThis retrospective register study used secondary data from the Finnish MS register. The DMTs were classified into medium‐efficacy DMTs (meDMTs; beta interferons, glatiramer acetate, fumarates, and teriflunomide) and high‐efficacy DMTs (heDMTs; alemtuzumab, cladribine, daclizumab, natalizumab, ocrelizumab, ofatumumab, and rituximab).ResultsThe inclusion criteria were fulfilled by 2479 individuals. From 2013 to 2022, the proportion of heDMTs as the initial therapy increased by 5.3‐fold from 6.9% to 43.7% (p < 0.001). Median diagnostic delay decreased from 10.1 to 4.6 months (p < 0.001). The COVID‐19 pandemic did not cause treatment delays. Higher disease activity and younger age were associated with the choice of heDMT as the initial DMT. heDMTs were the preferred second DMT in patients switching due to lack of efficacy.ConclusionIn Finland, the treatment of RRMS has shifted toward earlier diagnosis and earlier initiation of heDMTs, likely improving the prognosis of the patients.
Accumulate or Diversify Ecological Innovation Assets? The Effect of Ecological Innovation Asset Depth and Breadth on Firm Financial Performance
Authors: Gropengießer‐Arlt Louisa , Zacharias Nicolas A. 
Published: February 2025

ABSTRACTThis study investigates the role of innovation portfolio structures in the relationship of ecological innovation and firm financial performance. We draw on the resource‐based view and the natural resource–based view to examine the effects of the depth and breadth of firms' ecological innovation assets (EIAs) while conceptually and empirically accounting for the substantial differences between two distinct firm financial performance dimensions. To test our conceptual framework, we rely on a panel data set based on 340 US firms listed in the S&P 500 index over a 10‐year period. Fixed‐effects regressions confirm that EIA depth and EIA breadth fundamentally differ in their effects on firm financial performance. Moreover, we find that the results vary considerably between accounting‐based and value‐based financial performance. Thereby, this study makes a significant contribution to the ongoing debate about the nexus of ecological innovation and firm financial performance.
Family Embeddedness Is Detrimental to Going Green: Family Involvement and Green Strategies
Authors: Ali Asif , Shen Zunhuan , An Pengbei , Ali Farman , Ali Imran 
Published: February 2025

ABSTRACTWe investigate the intensely debated but unexplored question of how family involvement affects corporate green strategies. Employing a dataset of 4750 firm‐year observations over the period of 2015–2021 of Chinese A‐listed family firms, our empirical findings indicate that family involvement has a negative and significant relationship with corporate green strategies. These outcomes are consistent with the socio‐emotional wealth (SEW) “dark side.” Our outcomes suggest that this relationship is strengthened in highly polluted firms. Furthermore, we employ a series of additional checks, namely, alternative measures, endogeneity test, count data models, family involvement measures, future impact test, the explanatory variable lag by one period, sample change and heterogeneity test, and the outcomes of all these tests show that baseline findings remain robust after employing a series of these tests. The given study has crucial theoretical and practical implications for regulators, policymakers and practitioners, especially because it provides key insights into the inside stakeholders of family firms. To promote environmental efforts in family‐involved firms, policymakers ought to enact legislation or specific incentives. When assessing a company's sustainability commitment, stakeholders and investors should also take family involvement into consideration.
‘Pedagogical Perspectives to Ponder’: Engaging With Social Justice—An Integrative Pedagogy of Discomfort and Love in Psychotherapy
Authors: O'Brien Charlotte , Charura Divine 
Published: February 2025

ABSTRACTBackgroundThe purpose of this perspective piece is to illuminate the urgency of focussing on pedagogical approaches that facilitate social justice and anti‐discriminatory practice. We propose novel experiential activities for the classroom, which can then be applied to the diverse contexts and communities where trainees live.AimThe aim of this paper is to propose a pedagogical prime to be utilised by psychotherapeutic training educators, to help trainees to engage with the use of anti‐discriminatory and socially just practices early in a their academic training.Materials and MethodA pedagogical prime of experiential learning activities for social justice and anti‐discriminatory practice is proposed. Examples of engaging with an integrative pedagogy of discomfort and love in psychotherapy training are presented as a method for facilitating a depth of reflective practice.ResultsThe process of engaging with this pedagogical prime has a powerful impact on self‐awareness, reflective and reflexive practice. These facilitate the trainees' personal and professional development, and integration of theory and practice. The pedagogical prime activities also serve to develop culturally informed, anti‐oppressive and relational attributes as part of a firm commitment to social justice.DiscussionAttainment of these attributes in social justice and anti‐discriminatory practice enable trainees not only to develop into professional psychotherapeutic practitioners, but also into global citizens with an awareness of social justice. As educators, we have a responsibility to continue to work to decolonise the curriculum, starting at the grass‐roots level with how we engage pedagogically with anti‐discriminatory, socially just language in the classroom. As psychotherapeutic practitioners, we are also ethically required by law to engage in anti‐discriminatory practices whilst serving diverse populations, yet we often lag behind in training approaches which aspire towards social justice.ConclusionThis paper advocates for further research into the proposed pedagogic prime, utilising an integrated pedagogy of discomfort with a pedagogy of love. It also advocates for early lessons on language in psychotherapeutic and psychological training programmes, shifting the focus of social justice and anti‐discriminatory practice to the forefront of trainees’ consciousness from the start of training.
Why Female Virtual Conversational Agents Exhibit Greater Social Presence: Insights From the Stereotype Content Model
Authors: Nickel Kristina , Meyer Caroline 
Published: February 2025

ABSTRACTIn recent years, companies have increasingly adopted virtual conversational agents (VCAs) to interact with their consumers. A significant number of these agents are assigned to a specific gender, typically female, thereby reinforcing gender‐related stereotypes. This work employs the stereotype content model (SCM), especially focusing on the two subdimensions sociability and morality, to investigate how the VCA's gender impacts social presence in two studies (Study 1: avatars; Study 2: chatbots). Both studies show an indirect effect of the VCA's gender (female) on social presence through sociability, but not through morality. Contrary to expectations, the indirect effect through sociability is significant for both male and female consumers. The findings indicate that the indirect effect is robust across different product categories (i.e., finance, fashion, holiday trip, and toothbrush) and types of VCAs (i.e., visual and verbal). This research demonstrates how established stereotype theories (i.e., SCM) can serve as a valuable framework for exploring human‐machine communication. Moreover, the results provide a fundamental basis for addressing and reducing the persistence of gender stereotypes, initiating a more extensive discussion about the ethical considerations related to interactions between humans and technology.
Gallic Acid Derivatives Are the Active Ingredients of the Optimized Phenolic Extracts of Chinese Tallow Tree
Authors: Zhang Yuting , Guo Yiran , Fu Rao 
Published: February 2025

ABSTRACTThe Chinese tallow tree (Sapium sebiferum (L.) Roxb) (CTT) is a valuable forest resource, and its leaves have long been utilized in Traditional Chinese Medicine for the treatment of various diseases, primarily due to the antioxidant activity of phenolic compounds. In this study, a simple ultrasonic‐assisted phenolic extraction method was established using response surface methodology. The highest total phenolic content was obtained by extracting with 40% ethanol (v/v) in a solid‐liquid ratio (g/mL) of 1:48 for 20 min at 30°C, employing an ultrasonic bath with a power of 270 W and a frequency of 40 kHz. Using the optimized phenolic extract, a non‐target metabolomics approach was adopted to evaluate the antioxidant ingredients of the CTT. Most of the identified phenolic compounds were depleted after reacting with free radicals, indicating their significant contribution to the antioxidant activity of CTT leaves. Among them, gallic acid derivatives, geraniin, and ethyl gallate were identified as the predominant antioxidant ingredients. Overall, a simple ultrasonic‐assisted phenolic extraction method was optimized, and the antioxidant ingredients of the valuable CTT leaves were identified. These findings significantly promote the development and application of CTT leaves.
Biological and in Silico Studies of a Novel Pyrazolo[3,4‐d] Thiazole Derivatives: Anticancer, Anti‐inflammatory, Molecular Docking and SAR
Authors: El Behery Mohammed , El-Namaky Ruwaida I. , Abu Almaaty Ali H. , El-Deen Ibrahim M. 
Published: February 2025

This study synthesized and evaluated a series of novel 1,3,5‐trisubstituted‐1H‐pyrazolo[3,4‐d]thiazole derivatives (5a, 5b, 6a, 6b, and 7) for their cytotoxic, anti‐inflammatory, and anticancer properties. The cytotoxic activity of these derivatives was evaluated against MCF‐7 and HepG2 cell lines. Compound 6b demonstrated the most potent anticancer activity, with IC50 values of 15.57 ± 2.93 µg/mL for MCF‐7 cells and 43.72 ± 1.90 µg/mL for HepG2 cells, demonstrating greater efficacy than doxorubicin. Mechanistic studies revealed that compound 6b induced S‐phase arrest in MCF‐7 cells and G1/S‐phase arrest in HepG2 cells, along with a significant increase in apoptosis rates in the treated cancer cells. Moreover, compound 6b demonstrated significant VEGFR‐2 inhibition, surpassing the efficacy of sorafenib. Compounds 5b and 6b demonstrated significant anti‐inflammatory activity in RAW264.7 macrophage cells, as indicated by the decrease in nitric oxide (NO) production and the downregulation of proinflammatory cytokines, such as IL‐1β, IL‐6, and TNF‐α. The derivatives exhibited no cytotoxicity towards normal cell lines (MCF‐10A, THLE‐2, and Vero cells), as validated by MTT assays. Docking studies elucidated the interaction mechanism between the compounds and the enzyme receptors. These findings demonstrate compound 6b as a promising candidate for the development of dual‐function anticancer and anti‐inflammatory agents.
Potential Ligands to Resistin Against Prostate Cancer, Evaluated by Molecular Docking and In Vitro Assays to Develop an Anticancer Drug
Authors: Rivera‐Suárez Bryan A. , García González Victor G. , Chimal‐Vega Brenda , Navarro Padrón Anna C. , Galindo‐Hernández Octavio , Vique‐Sánchez José L. 
Published: February 2025

ABSTRACTOverweight and obesity are risk factors that increase the white adipose tissue (WAT) that promotes the release of adipokines (adiponectin, leptin, and resistin). The increase of the resistin levels contributes to different cellular processes; regulation in the metabolism, inflammation process, and particularly in messengers in some cancer types. Resistin promotes cell proliferation and migration. Therefore, resistin is proposed as a multipotential therapeutic target to treat different diseases, and in this study, we focus on the regulation of resistin and its effect on prostate cancer. This study proposes compounds selective to resistin, these were selected and evaluated by molecular docking and in vitro assays, to develop a new drug against the resistin´s functions related to interaction with their potential receptors (Δ‐DCN, TLR4, and CAP‐1). These molecules with pharmacological characteristics are capable of interacting in the regions of resistin to hinder/block the interaction between resistin and their possible receptors (Δ‐DCN, TLR4, and CAP‐1). We determined two compounds that showed to be selective against resistin by in vitro assays. In this way, this study proposes compounds that were developed to be selective against resistin, and it could decrease the effect known of resistin by their receptors related to the proliferation of cancer.
Applications of Liquid–Liquid Phase Separation in Biosensing
Authors: Huang Huizhen , Hu Jun 
Published: February 2025

AbstractPhase separation, particularly liquid‐liquid phase separation (LLPS), has emerged as a powerful tool in biological research, offering unique advantages for visualizing and analyzing biomolecular interactions. This review highlights recent advances in leveraging LLPS to develop experimental techniques for studying protein‐protein interactions (PPIs), protein‐RNA interactions, and enzyme activity. The integration of LLPS with advanced techniques has expanded its applications, offering new possibilities for unraveling the complexities of cellular function and disease mechanisms. Looking forward, the development of more versatile, sensitive, and targeted LLPS‐based methods is poised to transform molecular biology, providing deeper insights into cellular dynamics and facilitating therapeutic advancements.
Chronic Kidney Disease and Risk of Mortality and Major Adverse Limb Events After Femoral Artery Endovascular Revascularization for Peripheral Artery Disease: The Boston Femoral Artery Endovascular Revascularization Outcomes (Boston FAROUT) Study
Authors: Evans Peter , Sobieszczyk Piotr , Eisenhauer Andrew C. , Todoran Thomas M. , Kinlay Scott 
Published: February 2025

ABSTRACTBackgroundChronic kidney disease (CKD) is associated with worse outcomes in peripheral artery disease (PAD). The impact of the severity of CKD on mortality and major adverse limb events (MALE) after endovascular revascularization of the superficial femoral artery (SFA) is unknown.AimsTo assess the relationship of increasing severity of CKD on the risk of mortality and MALE in patients after endovascular revascularization of the SFA.MethodsWe followed a cohort of 202 patients (253 limbs) with SFA endovascular revascularization for claudication or chronic limb‐threatening ischemia in two academic centers between 2003 and 2011. Patients were categorized into four Kidney Disease Improving Global Outcomes (KDIGO) categories of increasingly worse CKD based on estimated glomerular filtration rate (eGFR). The primary outcome was all‐cause death. Secondary outcomes included cardiovascular death, noncardiovascular death, and MALE. The relationship between CKD severity and outcomes was assessed by hazard ratios (HR) and 95% confidence intervals (95%CI) from cause‐specific multivariable Cox proportional hazards models and Fine‐Gray competing risks analyses.ResultsDuring a median follow‐up of 9.3 years, there was a graded and increasing risk of all‐cause, cardiovascular, and noncardiovascular mortality with worse eGFR (all tests of trend p < 0.001). The lowest eGFR category (< 45 mL/min/1.73 m²) was associated with the highest risk of all‐cause mortality (HR = 5.0, 95% CI = 2.4, 10), cardiovascular mortality (HR = 5.8, 95% CI = 1.8, 18), and noncardiovascular mortality (HR = 4.5, 95% CI = 1.9, 11). There was no significant association between CKD severity and MALE or minor revascularization events.ConclusionThe risk of mortality risk after SFA endovascular revascularization incrementally increases with decreasing renal function. However, impaired renal function is not related to the risk of adverse limb events and supports femoral revascularization in these patients.
Necrotizing Pancreatitis in a Patient Diagnosed With SLE: A Rare Case Report
Authors: Javid Maryam , Damideh Tohid , Pourbagherian Omid , Jafarpour Mehdi 
Published: February 2025

ABSTRACTNecrotizing pancreatitis is an extremely rare but serious complication of systemic lupus erythematosus (SLE). Early recognition and appropriate treatment, including steroids and immunosuppressive therapy, are critical for improving outcomes in SLE patients with this condition.
Navigating the Hazards: A Case Study on the Complexities of Battery Ingestion in an Adult
Authors: Dang Ashujot K. , Choday Prithi , Buitrago Carlos , Saffouri George 
Published: February 2025

ABSTRACTThis case underscores the potential for prolonged colonic retention of ingested batteries (even over a month) necessitating endoscopic retrieval. Early detection, prompt intervention, and preventive measures are crucial to prevent life‐threatening complications in high‐risk patients. Additionally, outpatient scheduled follow‐ups and management of recurring ingestions may help improve patient outcomes.
Severe Actinomycotic Discitis Osteomyelitis and Bacteremia in an Immunocompetent Adult Following Dental Cleaning: A Case Report
Authors: Khan Malik W. Z. , Moeez Abdul , Farooq Sameen , Azeem Touba , Ahmad Muhammad , Ali Aizaz , Khan Faheemullah 
Published: February 2025

ABSTRACTActinomycotic vertebral osteomyelitis is a rare but severe condition, even in immunocompetent individuals, following routine dental procedures. Prompt recognition, multidisciplinary management, and tailored antibiotic therapy are crucial for optimizing outcomes. Clinicians should maintain a high index of suspicion for Actinomyces in patients with unexplained spinal infections and recent dental interventions.
The S1Q3T3 Electrocardiographic Abnormality as a Result of Massive Empyema due to Pyogenic Liver Abscess: A Case Report
Authors: Mohammadi Mahmonir , Valizadeh Mahnaz , Rahmani‐ju Nasrin , Khosravaninezhad Yasamin 
Published: February 2025

ABSTRACTThe S1Q3T3 pattern on the electrocardiogram is often associated with right heart strain in pulmonary embolism, pneumothorax, and acute lung diseases causing acute cor pulmonale. The S1Q3T3 pattern during acute massive empyema in the setting of a liver abscess has not been reported in theliterature. We present a case report of a 41‐year‐old Iranian female patient with a sudden onset chest pain, dyspnea, sinus tachycardia, and electrocardiography findings of S1Q3T3 pattern, who was revealed to have an expanding pyogenic pleural effusion as a result of trans‐diaphragmatic extension of a liver abscess. The other causes of S1Q3T3 were excluded. The patient underwent the insertion of a chest tube to remove the pus. After chest tube insertion, the S1Q3T3 pattern resolved. Despite initial improvement, the patient developed complications, including pleural adhesions and lung collapse, and required a posterolateral thoracotomy with decortication. This resulted in dramatic clinical improvement. Rapidly expanding massive pyogenic pleural effusion can lead to the S1Q3T3 pattern on the electrocardiogram.
Unusual Etiology of an Ischemic Stroke: Total Thrombosis of the Right Internal Carotid Artery in a Case Report
Authors: Nacanabo Wendlassida Martin , Seghda Taryètba André Arthur , Tall/Thiam Anna , Yameogo Nobila Valentin , Samadoulougou André Koudnoaga , Zabsonre Partice 
Published: February 2025

ABSTRACTThis case presents an unusual finding of total thrombosis of the right internal carotid artery complicated by a large patch of cerebral ischaemia in the right parieto‐temporo‐occipital and right capsulo‐lenticulo‐thalamic regions. The patient was managed mainly with medication, due to the lack of human and material resources required for any intervention.
Robotic‐Assisted Radical Cystectomy and Acute Intraoperative Hyperkalemia: A Case Series
Authors: Khalili Amro , Raphael Christian K. , Shreim Rasha , Nafeh Nancy Abou , Karam Cynthia 
Published: February 2025

ABSTRACTTaking into consideration the effects of pneumoperitoneum on kidney function, anesthesiologists should diligently monitor potassium levels during robotic‐assisted radical cystectomy, particularly during prolonged ureter clamping, in the presence of chronic kidney disease, administration of renin‐angiotensin‐aldosterone system‐blocking medications, or when there is a high risk of rhabdomyolysis.
Popliteal Artery Rupture: A Rare but Life‐Threatening Complication of Total Knee Arthroplasty
Authors: Willett Yanna , Meli Gabrielle , Meli Paul , Lack Benjamin , Benson Katerina , Kitsantas Panagiota , Hennekens Charles H. 
Published: February 2025

ABSTRACTPopliteal artery rupture is a rare but life‐threatening complication of total knee arthroplasty. In order to prevent dangerous outcomes, such as amputation or death, immediate vascular intervention is needed. This case highlights the importance of intraoperative vigilance and prompt action to mitigate these risks.
Coinfection by Mucoraceae and Aspergillus Species in a Patient With Acute Leukemia: A Clinical Case Report
Authors: Hakamifard Atousa , Peikar Mohammadsaleh , Tabatabaei Seyed Amirhossein Dormiani 
Published: February 2025

ABSTRACTThe concurrent occurrence of invasive mold infections caused by two distinct fungal species in hematologic patients represents a rare and challenging condition. The mortality rate associated with these invasive fungal infections in neutropenic patients is high, underscoring the importance of timely diagnosis and prompt initiation of appropriate treatment to improve clinical outcomes. Herein, we present a concomitant acute invasive fungal rhinosinusitis (AIFR) and invasive pulmonary fungal infection caused by Aspergillus and Mucoraceae species in a patient with pre‐B‐cell acute lymphoblastic leukemia. This case highlights the need for further research to optimize outcomes in immunocompromised patients.
Emphysematous Pyelonephritis: A Conservative Approach
Authors: Veiga Carolina , Sevivas Rita , Paulo Gabriela , Coelho Ilda 
Published: February 2025

ABSTRACTEmphysematous pyelonephritis is an entity most commonly treated through surgery, with the associated risks and complications; the use of a more conservative approach, using antibiotics alone in selected patients, may prove to have favorable outcomes with fewer complications and risks, as described in this case.