bluuebunny/crossref_metadata_2025_split huggingface dataset:
Active principles of Grindelia robusta exert antiinflammatory properties in a macrophage model
Authors: La Vu Dang , Lazzarin Francesco , Ricci Donata , Fraternale Daniele , Genovese Salvatore , Epifano Francesco , Grenier Daniel 
Published: June 2010

AbstractPlant extracts and/or secondary metabolites are receiving considerable attention as therapeutic agents for treating inflammatory diseases such as periodontitis, which affects the tooth supporting tissues. The aim of this study was to investigate the effect of a Grindelia robusta extract enriched in saponins and polyphenols on Aggregatibacter actinomycetemcomitans lipopolysaccharide (LPS)‐induced inflammatory mediator (IL‐6, TNF‐a, RANTES, MCP‐1, PGE2) and matrix metalloproteinase (MMP‐1, ‐3, ‐7, ‐8, ‐9, ‐13) secretion by macrophages. LPS induced a marked increase in the secretion of all inflammatory mediators and MMPs tested by macrophages, as determined by enzyme‐linked immunosorbent assays. At non‐cytotoxic concentrations, the G. robusta extract inhibited dose‐dependently the secretion of IL‐6, RANTES, MCP‐1 and, to a lesser extent, PGE2 and TNF‐a. Such inhibition was also observed for MMP‐1, ‐3, ‐7, ‐8, ‐9 and ‐13 secretion. This ability of G. robusta extract to reduce the LPS‐induced secretion of inflammatory mediators and MMPs was associated with a reduction of nuclear factor‐kappa B (NF‐kB) p65 activation. The results suggest that G. robusta extract possesses an antiinflammatory therapeutic potential through its capacity to reduce the accumulation of inflammatory mediators and MMPs. Copyright © 2010 John Wiley & Sons, Ltd.
Theoretical analysis on the hydrogen bonding and reactivity that associated with the proton transfer reaction of carboxylic acid dimers and their monosulfur derivatives
Authors: Wu Dongling , Jia Dianzeng 
Published: June 2010

AbstractCarboxylic acid dimers and their monosulfur derivatives are investigated by density functional theory calculations. Basis set superposition error (BSSE) counterpoise correction is included to compare the influence of BSSE on the interaction energies as well as on the geometries. The nature of hydrogen bond is determined on the basis of atoms in molecules (AIM) and natural bond orbital (NBO) analyses. Good correlations have been established between H‐bond length versus AIM topological parameter, orbital interaction, and barrier height for proton transfer. The reactivity behavior along the reaction path of the double proton transfer reaction has also been studied. © 2010 Wiley Periodicals, Inc. Int J Quantum Chem, 2011
Insight into Markovnikov regioselectivity rule via molecular face and ABEEM‐σπ theory
Authors: Ding Yan‐Li , Mu Ji‐Rong , Wang Chun‐Hui , Yang Zhong‐Zhi 
Published: June 2010

AbstractElectrophilic additions of HCl to a series of asymmetric alkenes in the gas phase are investigated by the Molecular Face (MF) theory and ABEEM‐σπ model. The interesting features of regioselectivity for these reactions are characterized by the electron density (ED) encoded on the MF of alkenes and charge distribution of alkenes obtained via the ABEEM‐σπ model, respectively. It is then demonstrated that for a series of alkenes, the Hammett constant σp (substituent constant) has a good linear correlation with KED, where KED is character of the ED at the π region in the initial state of alkenes. Comparison between investigations using MF, ABEEM‐σπ, molecular electrostatic potential, and DFT theories, in essence, give similar conclusions for explaining the regioselectivity of the electrophilic additions to alkenes, although from different points of view. © 2010 Wiley Periodicals, Inc. Int J Quantum Chem, 2011
Partial order semantics for use case and task models
Authors: Sinnig Daniel , Khendek Ferhat , Chalin Patrice 
Published: June 2010

Abstract

Use case models are the specification medium of choice for functional requirements, while task models are employed to capture User Interface (UI) requirements and design information. In current practice, both entities are treated independently and are often developed by different teams, which have their own philosophies and lifecycles. This lack of integration is problematic and often results in inconsistent functional and UI design specifications causing duplication of effort while increasing the maintenance overhead. To address these shortcomings, we propose a formal semantic framework for the integrated development of use case and task models. The semantic mapping is defined in a two step manner from a particular use case or task model notation to the common semantic domain of
sets of partially ordered sets
. This two-step mapping results in a semantic framework that can be more easily reused and extended. The intermediate semantic domains have been carefully chosen by taking into consideration the intrinsic characteristics of use case and task models. As a concrete example, we provide a semantics for our own DSRG use case formalism and an extended version of ConcurTaskTrees, one of the most popular task model notations. Furthermore, we use the common semantic model to formally define a set of refinement relations for use case and task models.
Body size determines rates of seed dispersal by giant king crickets
Authors: King Peter , Milicich Leslie , Burns Kevin C. 
Published: June 2010

AbstractNew Zealand is home to giant king crickets called weta, which are the only insects known to consume fleshy‐fruits and disperse seeds after gut passage. Although they disperse seeds in viable condition after consumption, their importance as seed dispersers is unknown. We conducted a series of field observations and laboratory experiments to investigate intraspecific variation in the capacity of Wellington tree weta (Hemidenina crassidens) to disperse seeds of tree fuchsia (Fuchsia excorticata). We asked three questions. How frequently do weta disperse fuchsia seeds? Do seed passage rates differ between sexes and different‐sized weta? Might weta select for particular seed sizes via differential seed mortality after ingestion? A total of 2,272 F. excorticata seedlings germinated from 241 scats (i.e., faecal pellets) that were collected from the field. Experimental results showed that, on average, 15% of seeds ingested by weta successfully germinated, whereas 75% germinated in control trials. Larger weta dispersed greater numbers of seeds in experimental trials, while no differences in dispersal rates were observed between sexes. Regardless of sex and size, weta preferentially dispersed larger seeds. When interpreted collectively, results indicate that (1) weta are frequent seed dispersers of F. excorticata, although many seeds are destroyed during ingestion, (2) larger‐bodied weta consistently disperse greater quantities of seeds, which is unusual in seed dispersal mutualisms, and (3) weta preferentially disperse larger seeds, suggesting that they might interact evolutionarily with New Zealand plants.
Newborn screening for neuropathic lysosomal storage disorders
Authors: Hwu Wuh‐Liang , Chien Yin‐Hsiu , Lee Ni‐Chung 
Published: June 2010

AbstractInterest in newborn screening (NBS) for lysosomal storage disorders (LSDs) has increased significantly due to newly developed enzyme replacement therapy (ERT), the need for early diagnosis, and advances in technical developments. Since the central nervous system cannot be treated by ERT, neuronopathic LSDs are generally not the primary target of NBS. An exception is Krabbe disease, in which hematopoietic stem cell transplantation before the onset of symptoms has benefits. However, NBS for LSD relies on measuring enzyme activities, so the most severely affected individuals (usually patients with neuronopathic subtypes) will be detected together with patients with less severe disease. In the near future, NBS is likely to be developed for diseases such as Gaucher, Niemann‐Pick A/B, and certain mucopolysaccharidoses. The ability to predict phenotypes (neuronopathic or not) by enzyme activity and genotyping will therefore be critical for adequate patient management. This article reviews the status of LSD screening and issues concerning detection of neuronopathic LSDs by screening.
Evaluation of the biotinidase activity in hepatic glycogen storage disease patients. Undescribed genetic finding associated with atypical enzymatic behavior: an outlook
Authors: Angaroni Celia J. , Giner‐Ayala Alicia N. , Hill Lorena P. , Guelbert Norberto B. , Paschini‐Capra Ana E. , de Kremer Raquel Dodelson 
Published: June 2010

AbstractRepeated evaluation of biotinidase (BTD) activity was carried out for a long‐term follow‐up in patients with hepatic glycogen storage diseases (GSDs). The results indicated inter‐intra variability among the GSD‐Ia, GSD‐III and GSD‐IX patients. In addition, a c.1330G>C transversion in the BTD gene, resulting in a p.Asp444His substitution was detected in one allele of a GSD‐Ia patient with sustained normal enzyme activity. Thus far, it is necessary to be cautious in the interpretation of the results of BTD activity as a presumptive GSD diagnostic element. It is not known why plasma BTD activity increases in GSDs patients, or the clinical importance of the increment. When viewed from a global perspective, there are some lines of biotin biology that could indicate a relationship between BTD´s behavior and GSDs.
“Couch surfing” of Latino foster care alumni: Reliance on peers as social capital
Authors: Perez Beatrix F. , Romo Harriett D. 
Published: June 2010

ABSTRACTYouth exiting foster care often experience difficulties transitioning into adulthood. This paper focuses on Latino foster care youth in a major southwestern U.S. city and addresses the importance of peer networks as a crucial form of social capital as youth leave foster care. Case studies illustrate experiences of foster care alumni ranging in age from 18 to 26. Findings suggest that lack of housing forces youth into residential mobility or “couch surfing” and episodes of homelessness. Familial connections continue to be important to Latino youth. When Latino youth are unsuccessful in re‐establishing family relationships, survival is dependent upon peer social capital as youth move between extended family and friends, eventually relying upon peers for support. Recommendations are included.
Second-generation antipsychotics and constipation: A review of the literature
Authors: Hert M. De , Hudyana H. , Dockx L. , Bernagie C. , Sweers K. , Tack J. , Leucht S. , Peuskens J. 
Published: June 2010

AbstractAntipsychotics are the cornerstone in the management of psychotic disorders and schizophrenia. They are effective agents but also have a wide range of side effects. In the recent literature constipation as possible side effect has received little attention. A review of the literature concerning constipation associated with antipsychotics was performed. Overall constipation is a rarely studied or reported side effect of antipsychotic medication. Nevertheless constipation is a common side effect. Antipsychotic agents differ in their liability to induce constipation. Constipation can be severe and can lead to serious consequences such as paralytic ileus, bowel occlusion and death. Active screening, monitoring and treatment are recommended. Further research on incidence, prevalence, underlying mechanisms and preventive measures is required.
The impact of pregnancy and vaginal delivery on urinary incontinence
Authors: Huebner Markus , Antolic Andrea , Tunn Ralf 
Published: June 2010

AbstractObjectiveTo identify women who had urinary incontinence (UI) before, during, and after pregnancy, and to determine whether women with symptoms of UI during pregnancy were the same women who had urinary incontinence postpartum.MethodsAll primigravid women who delivered within 1 year (1999) at the Charité Hospital in Berlin received a questionnaire about UI at 5 different time points during pregnancy and the postpartum period.ResultsOf 610 eligible women, 411 (67.4%) completed the questionnaire. The prevalence of urinary incontinence increased significantly in the second half of pregnancy (26.3%, P < 0.001). Although the overall number of women who reported UI within 6 weeks after delivery (28.5%) was almost the same as the number reporting UI in the second half of pregnancy, approximately every second women changed from being continent to incontinent and vice versa.ConclusionThe group of women who experienced UI postpartum was different from the group that experienced UI before delivery and vice versa. Pregnancy itself may influence pelvic floor function in a different way compared with vaginal delivery.
Genetic variation in theLMP/TAPgene and outcomes of hepatitis B virus infection in the Chinese population
Authors: SHI C. , QIAN Y.-H. , SU J. , LUO S.-S. , GU J. , YOU H. , CUI Q. , LIN Y.-D. , DONG M.-H. , YU R.-B. 
Published: June 2010

SUMMARYGenetic polymorphisms of theLMP/TAPgene coded by the HLA-II region may be associated with outcomes of HBV infection. We conducted a case-control study to test the hypothesis, including a persistent group of 155 patients with chronic hepatitis B and 36 healthy carriers, a recovered group of 165 individuals spontaneously recovered from HBV infection, and an uninfected group of 278 healthy normal controls. Genotypes of eight polymorphisms of theLMP/TAPgene were analysed by PCR–RFLP. A logistic regression model was used to analyse statistical differences in polymorphisms or haplotypes in different groups. Of the eight polymorphisms, two (TAP1codon 637 andLMP7codon 145) were observed to have statistically significant association with outcomes of HBV infection (P<0·05). The two-locus haplotype constructed with two such polymorphisms was analysed. The frequencies of haplotypes B (Asp-Lys), C (Gly-Gln), and D (Gly-Lys) were found to be increased significantly in the persistent group, compared to healthy controls (OR 2·26, 95% CI 1·62–3·15,P<0·001; OR 2·37, 95% CI 1·69–3·32,P<0·001; OR 4·38, 95% CI 1·78–10·77,P=0·001, respectively). The prevalence of haplotypes B (Asp-Lys), C (Gly-Gln), and D (Gly-Lys) were also significantly higher in the persistent infectious group than in the recovered group (OR 2·68, 95% CI 1·81–3·98,P<0·001; OR 2·40, 95% CI 1·62–3·55,P<0·001; OR 3·03, 95% CI 1·22–7·55,P=0·017, respectively). These findings indicated that genetic polymorphisms of theLMP/TAPgene might be an important factor in determining the outcome of HBV infection.
Testing seed-size predictions in Mediterranean annual grasslands
Authors: Azcárate Francisco M. , Manzano Pablo , Peco Begoña 
Published: June 2010

AbstractOn the basis of previous research, we predict that Mediterranean grasslands should show larger-seeded annuals in: (1) more-arid grasslands; (2) more-fertile soils; (3) less-grazed grasslands; and (4) grasslands with lower intensities of seed predation by ants. To test these predictions, we set 29 sampling units of 50 m × 50 m in a 1000 km2grassland area in Central Spain, and characterized them according to the former factors. We then recorded annual vegetation using ten quadrats of 20 cm × 20 cm in each sampling unit. Seed size at the community level was described using six variables: (1) mean seed mass; (2) standard deviation of seed mass; (3) weighted mean seed mass (by species frequencies); (4) proportion of small-seeded annuals; (5) proportion of medium-seeded annuals; and (6) proportion of large-seeded annuals. Most climate variables (mean annual temperature, length of the summer drought, water balance and mean annual precipitation) correlated with seed-size descriptors, showing that large-seeded annuals increase in warmer and more-arid communities. Mean seed size was modelled as a function of mean annual temperature and grazing pressure. According to this model, warmer and less-grazed communities tend to show a smaller mean seed size. These results confirm the importance of seed-size descriptors at the community level in Mediterranean grasslands, and the role of climate and grazing as major drivers in these communities. Conversely, hypotheses about soil fertility and seed predation by ants were not supported by our results.
Chronic Subjective Dizziness Versus Conversion Disorder: Discussion of Clinical Findings and Rehabilitation
Authors: Honaker Julie A. , Gilbert Jane M. , Staab Jeffrey P. 
Published: June 2010

Purpose
Audiologists frequently encounter patients who complain of chronic dizziness or imbalance, in the absence of active vestibular or neurological deficits. Knowledge about conditions that cause this clinical presentation will allow audiologists to make important contributions to accurate diagnosis and effective management of these patients. This article reviews 2 such conditions, chronic subjective dizziness (CSD) and conversion disorder.

Method
A case of CSD and another of conversion disorder are presented, with a literature review of their clinical presentations, key diagnostic features, and treatment strategies. The role of the audiologist in assessing patients with these conditions and facilitating appropriate treatment referrals is discussed.

Conclusions
The audiologist is in a key position to identify individuals with CSD and conversion disorder, 2 conditions that can be effectively managed if properly recognized. The authors demonstrate an effective team approach program that includes the audiologist’s contribution to differential diagnosis, education of patients and other clinicians about these conditions, and development of recommendations for neurological, psychiatric, otologic, and physical therapy referrals.
Lexical and Affective Prosody in Children With High-Functioning Autism
Authors: Grossman Ruth B. , Bemis Rhyannon H. , Plesa Skwerer Daniela , Tager-Flusberg Helen 
Published: June 2010

Purpose
To investigate the perception and production of lexical stress and processing of affective prosody in adolescents with high-functioning autism (HFA). We hypothesized preserved processing of lexical and affective prosody but atypical lexical prosody production.

Method

Sixteen children with HFA and 15 typically developing (TD) peers participated in 3 experiments that examined the following: (a) perception of affective prosody (Experiment 1), (b) lexical stress perception (Experiment 2), and (c) lexical stress production (Experiment 3). In Experiment 1, participants labeled sad, happy, and neutral spoken sentences that were low-pass filtered, to eliminate verbal content. In Experiment 2, participants disambiguated word meanings based on lexical stress (
HOTdog
vs.
hot DOG
). In Experiment 3, participants produced these words in a sentence completion task. Productions were analyzed with acoustic measures.

Results
Accuracy levels showed no group differences. Participants with HFA could determine affect from filtered sentences and disambiguate words on the basis of lexical stress. They produced appropriately differentiated lexical stress patterns but demonstrated atypically long productions, indicating reduced ability in natural prosody production.

Conclusions
Children with HFA were as capable as their TD peers in receptive tasks of lexical stress and affective prosody. Prosody productions were atypically long, despite accurate differentiation of lexical stress patterns. Future research should use larger samples and spontaneous versus elicited productions.
SPEX2: automated concise extraction of spatial gene expression patterns from Fly embryo ISH images
Authors: Puniyani Kriti , Faloutsos Christos , Xing Eric P. 
Published: June 2010

Abstract
Motivation: Microarray profiling of mRNA abundance is often ill suited for temporal–spatial analysis of gene expressions in multicellular organisms such as Drosophila. Recent progress in image-based genome-scale profiling of whole-body mRNA patterns via in situ hybridization (ISH) calls for development of accurate and automatic image analysis systems to facilitate efficient mining of complex temporal–spatial mRNA patterns, which will be essential for functional genomics and network inference in higher organisms.
Results: We present SPEX2, an automatic system for embryonic ISH image processing, which can extract, transform, compare, classify and cluster spatial gene expression patterns in Drosophila embryos. Our pipeline for gene expression pattern extraction outputs the precise spatial locations and strengths of the gene expression. We performed experiments on the largest publicly available collection of Drosophila ISH images, and show that our method achieves excellent performance in automatic image annotation, and also finds clusters that are significantly enriched, both for gene ontology functional annotations, and for annotation terms from a controlled vocabulary used by human curators to describe these images.
Availability: Software will be available at http://www.sailing.cs.cmu.edu/
Contact: epxing@cs.cmu.edu
Supplementary information: Supplementary data are avilable at Bioinformatics online.
Multivariate multi-way analysis of multi-source data
Authors: Huopaniemi Ilkka , Suvitaival Tommi , Nikkilä Janne , Orešič Matej , Kaski Samuel 
Published: June 2010

Abstract
Motivation: Analysis of variance (ANOVA)-type methods are the default tool for the analysis of data with multiple covariates. These tools have been generalized to the multivariate analysis of high-throughput biological datasets, where the main challenge is the problem of small sample size and high dimensionality. However, the existing multi-way analysis methods are not designed for the currently increasingly important experiments where data is obtained from multiple sources. Common examples of such settings include integrated analysis of metabolic and gene expression profiles, or metabolic profiles from several tissues in our case, in a controlled multi-way experimental setup where disease status, medical treatment, gender and time-series are usual covariates.
Results: We extend the applicability area of multivariate, multi-way ANOVA-type methods to multi-source cases by introducing a novel Bayesian model. The method is capable of finding covariate-related dependencies between the sources. It assumes the measurements consist of groups of similarly behaving variables, and estimates the multivariate covariate effects and their interaction effects for the discovered groups of variables. In particular, the method partitions the effects to those shared between the sources and to source-specific ones. The method is specifically designed for datasets with small sample sizes and high dimensionality.
We apply the method to a lipidomics dataset from a lung cancer study with two-way experimental setup, where measurements from several tissues with mostly distinct lipids have been taken. The method is also directly applicable to gene expression and proteomics.
Availability: An R-implementation is available at http://www.cis.hut.fi/projects/mi/software/multiWayCCA/
Contact: ilkka.huopaniemi@tkk.fi; samuel.kaski@tkk.fi