bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geology, Geochemistry, and Geochronology of the Fenghuangshan Skarn‐type Copper Deposit in the Tongling Ore Cluster, Anhui Province, East China
Authors: Hongying QU , Rongfu PEI , Hongcai FEI , Jinwen LI , Yonglei WANG , Haolin WANG , Lei YAO 
Published: July 2012

Abstract:The Fenghuangshan skarn‐type Cu deposit, Tongling Ore Cluster, Anhui Province, is an important component in the Middle—Lower Yangtze River ore‐forming belt. To better understand magmatism and its relationship to mineralization, we investigated geochemical features, ore‐forming fluids, and geochronology of the Xinwuli intrusion and the related Fenghuangshan Cu deposit. Lithogeochemical characteristics show that the Xinwuli quartz monzodiorite is formed by mixing magma derived from upper mantle alkaline basalt that has been contaminated by crust materials. C, H and O isotopes indicate that ore‐forming fluids mainly come from the magma, with minor amounts of meteoric fluids involved at the late stage. S and Pb isotopic components indicate that ore‐forming materials are derived from the mantle. Molybdenite Re—Os isotopic dating yields Re—Os model ages ranging from 139.1±2.4 Ma to 142.0±2.2 Ma, with an isochronal age of 141.1±1.4 Ma, which is consistent with sensitive, high‐resolution ion microprobe (SHRIMP) zircon U—Pb ages of quartz monzodiorite and granodiorite in the mining area. Dating analysis yields ages from 136.0±2.0 Ma to 143.0±2.4 Ma for the quartz monzodiorite (a weighted average of 139.4±1.2 Ma) and ages from 136.7±2.0 Ma to 145.3±2.4 Ma for granodiorite (a weighted average of 141.0±1.1 Ma).
Orderliness of Hydrocarbon Accumulation Distribution in Rift Basins of Eastern China
Authors: Xiyuan CAI 
Published: July 2012

Abstract:The Cenozoic rift basins in eastern China show a clear temporal and spatial zonation and episodic tectonic evolution, which control their episodic hydrocarbon generation and zonal accumulation. In this paper, based on the study of depositional architecture, hydrocarbon migration system and dynamic evolution in the rift basins, combinations of hydrocarbon accumulation elements were analyzed using sequence stratigraphy. Hydrocarbon distribution in system tracts with different sequence orders was further studied. And we summarized stacking patterns and horizontal combination relationships for different types of reservoirs, such as lithological, tectonic‐lithological, tectonic and stratigraphical reservoirs which can be observed from depression center to basin margin. The result reveals that various scales of pools exhibit significant distribution and evolution orderliness in different pool‐forming units, i.e., depositional systems, plays and depressions. The regular distribution of various scales of pools is closely related to tectonic evolution and depositional filling in the rift basins. The result can be applied to the fine petroleum exploration in rift basins in eastern China. It will promote the scientific prediction and evaluation of reservoir types and their spatial distribution, lead to the active shifts of exploration targets in different zones, and thus support the stable progress of fine exploration in mature exploration areas.
Suppression of liver regeneration affects hepatic graft survival in small‐for‐size liver transplantation in rats
Authors: Fu Wen‐Yi , Yan Ji‐Qi , Shi Min‐Min , Ma Di , Peng Cheng‐Hong , Li Hong‐Wei 
Published: July 2012

Aim:  Small‐for‐size liver transplantation (SFSLT) often results in hepatic graft failure and decreased survival. The present study was aimed to investigate the possible mechanism of hepatic graft failure in SFSLT in rats.Methods:  Rat models of full‐size orthotopic liver transplantation, 50% partial liver transplantation and 30% partial liver transplantation were established. Proliferative responses of the hepatic graft were evaluated by immunohistochemical staining and western blotting. Apoptosis‐, inflammatory‐, anti‐inflammatory‐ and growth factor‐related genes were screened by quantitative reverse transcription polymerase chain reaction. Activities of transcription factors of AP‐1 and nuclear factor (NF)‐κB were analyzed by electrophoretic mobility shift assay.Results:  A 30% partial liver transplant not only resulted in marked structural damages to the hepatic graft, but also showed the lowest 7‐day survival rate. In addition, sup pressed expressions of proliferating cell nuclear antigen (PCNA) and cyclin D1 by immunohistochemical staining and decreased expressions of cyclin D1 and p‐c‐Jun by western blotting were detected. Downregulated expressions of Bcl‐2, Bcl‐XL, interleukin (IL)‐6, IL‐10, IP‐10 and CXCR2, upregulated expression of tumor necrosis factor‐α, and decreased levels of AP‐1 and NF‐κB were also found following 30% partial liver transplantation after reperfusion.Conclusion:  Liver regeneration is remarkably suppressed in SFSLT. The significant changes of intra‐graft gene expression described above indicated that ischemia reperfusion injury would be severe in 30% partial liver transplantation. The capability of liver regeneration secondary to ischemia reperfusion injury might determine hepatic graft survival in SFSLT.
Rapid estimation of excess mortality: nowcasting during the heatwave alert in England and Wales in June 2011
Authors: Green Helen K , Andrews Nick J , Bickler Graham , Pebody Richard G 
Published: July 2012

BackgroundA Heat-Health Watch system has been established in England and Wales since 2004 as part of the national heatwave plan following the 2003 European-wide heatwave. One important element of this plan has been the development of a timely mortality surveillance system. This article reports the findings and timeliness of a daily mortality model used to ‘nowcast’ excess mortality (utilising incomplete surveillance data to estimate the number of deaths in near-real time) during a heatwave alert issued by the Met Office for regions in South and East England on 24 June 2011.MethodsDaily death registrations were corrected for reporting delays with historical data supplied by the General Registry Office. These corrected counts were compared with expected counts from an age-specific linear regression model to ascertain if any excess had occurred during the heatwave.ResultsExcess mortality of 367 deaths was detected across England and Wales in ≥85-year-olds on 26 and 27 June 2011, coinciding with the period of elevated temperature. This excess was localised to the east of England and London. It was detected 3 days after the heatwave.ConclusionA daily mortality model was sensitive and timely enough to rapidly detect a small excess, both, at national and regional levels. This tool will be useful when future events of public health significance occur.
Endovascular therapy of internal carotid artery bifurcation aneurysms
Authors: Oishi Hidenori , Yamamoto Munetaka , Nonaka Sensyu , Arai Hajime 
Published: July 2012

BackgroundInternal carotid artery (ICA) bifurcation aneurysms are uncommon. Therefore, there have been only a few endovascular series on ICA bifurcation aneurysms published to date. The purpose of this study is to report the safety and efficacy of endovascular therapy for ICA bifurcation aneurysms.MethodsThere were 25 ICA bifurcation aneurysms (unruptured n=23, ruptured n=2) in 25 patients in this study. There were 14 women, with a mean age of 60.9±10.1 years. All patients underwent endosaccular coil embolization.ResultsAneurysm size and neck size ranged from 2.5 to 10.0 mm (mean 5.4±1.5) and from 1.5 to 4.0 mm (mean 2.7±0.8), respectively. Regarding the clinical outcomes of the 23 patients with unruptured aneurysms, 22 patients had no change in their preprocedural modified Rankin Scale (mRS) score. The other patient died of ventilator associated aspiration pneumonia. Two patients with ruptured aneurysms each had scores of mRS 0. Overall morbidity and death rates were 0% and 4%, respectively. 15 aneurysms were treated with a simple technique. The 10 remaining aneurysms required adjunctive techniques: balloon assisted (n=9) and double catheter (n=1). The immediate anatomical outcomes were complete occlusion (n=19 (76.0%)), residual neck (n=4 (16.0%)) and residual aneurysm (n=2 (8.0%)). The overall follow-up of anatomical outcomes were unchanged (n=14 (63.7%)), improved (n=5 (22.7%)) and recurrence (n=3 (13.6%)). No patient suffered from aneurysmal subarachnoid hemorrhage after endovascular therapy. Thromboembolic events without clinical modification occurred in two patients.ConclusionsEndovascular therapy of ICA bifurcation aneurysms is safe and effective, with a low risk of recanalization and re-treatment.
O-002 A retrospective multicenter study of Solitaire device used for the revascularization in the treatment of acute ischemic stroke
Authors: Costalat V 
Published: July 2012

PurposeTo evaluate safety and efficacy of the Solitaire device when used as 1st choice device in the treatment of patients with acute ischemic stroke (AIS) secondary to large artery occlusion.MethodsA retrospective data collection on consecutive patients presenting with AIS treated with Solitaire device as first line device to restore blood flow in six experienced European sites from March 2009 to June 2010. An independent Core Lab evaluated TICI scores on the pre-procedure and post-procedure angiograms. Complete recanalization was defined as TICI 2b or three-post treatment. Baseline and post-treatment brain CT or MRI were also centrally reviewed to evaluate ASPECTS and symptomatic intracranial hemorrhage (SICH). The definition of SIH used is parenchymal hemorrhage type 2 + death or neurologic deterioration of 4 or more point of NIHSS. Patients were treated according to the hospitals' stroke protocols (direct IA, bridging IV t-PA/IA and failed or contraindicated IV t-PA). Sites provided patient information at pre-procedure, procedure, 24 h, discharge and 90 days. Good early neurological outcome was defined as NIHSS score improvement of ≥10 points or NIHSS 0, 1 at discharge, and favorable functional outcome as modified Rankin Scale (mRS) score ≤2 at day 90. Patients with missing mRS data were judged to have worst possible outcome for data analysis.ResultsOf the 206 patients treated with Solitaire device, the device was used as first line treatment in 141 patients (mean age, 66; median NIHSS, 18): 74 patients were treated with IV t-PA prior to endovascular treatment, 56 had contra indication to IV t-PA and 11 were directly treated IA. The revascularization success independently evaluated was 85%. The mean number of recoveries was 1.8 and median time from groin puncture to successful revascularization was 40 min. Good early neurological outcome at discharge was 41% and good clinical outcome at 90 days was 55%. Sub group analysis on results according to administration or not of IV tPA pre use of Solitaire device was performed. The two sub-groups were analyzed and considered statistically similar on criteria such as age, sex, NIHSS at baseline, ASPECTS at baseline, occlusion lesion site.ConclusionsThis retrospective, uncontrolled study shows the positive effect of Solitaire device in treatment of patients with acute ischemic stroke to restore flow and good clinical outcomes in patients with AIS and large artery occlusion.Competing interestsV Costalat: Covidien.
O-020 A comparison of infarct volumes in patients with large vessel occlusions based on treatment modality: a retrospective analysis: Abstract O-020 Figure 1
Authors: Rangaraju S , Owada K , Noorian A , Glenn B , Belagaje S , Anderson A , Nahab F , Frankel M , Nogueira R , Gupta R 
Published: July 2012

IntroductionIntra-arterial (IA) therapy for large vessel occlusions (LVO) results in higher recanalization rates compared to intravenous (IV) thrombolysis. Recanalization after LVO is also a predictor of better clinical outcome. Whether IA therapy results in lower stroke infarct burden has not previously been determined. Infarct volume has been shown to have a strong correlation to 90-day clinical outcome. We hypothesized that patients treated with IA therapy will have lower post-procedure infarct volumes compared to IV thrombolysis or untreated patients.Materials and methodsA retrospective chart review was performed on consecutive patients with LVO between November 2010 and December 2011 at Emory University Hospital and Grady Memorial Hospital. LVO was defined as extracranial/intracranial internal carotid artery (ICA), M1 middle cerebral artery (MCA) or M2 MCA occlusions identified by CT, MR or conventional angiography. Adults (>18 years) with LVO who presented within 8 h from time last seen normal were included and grouped as follows: those receiving intra-arterial/endovascular therapy(IA group), intravenous thrombolysis only(IV group)and no thrombolysis(Untreated group). Baseline characteristics were recorded on all patients. Infarct volume was measured using subsequent CT or MRI imaging after the first 24 h and compared using the Mann–Whitney U test. Data are represented as box plots showing the median infarct volume and the first and third IQRs for each group (Abstract O-020 figure 1A,B).Abstract O-020 Figure 1(A) Infarct Volumes in LVO. (B) Infarct volume based on location of occlusion and treatment modality.Results192 patients with LVO met inclusion criteria (IA: 127 patients, IV: 35 patients, Untreated: 30 patients).The mean age for the entire cohort was 66±16 years and the mean NIHSS was 19±6. Baseline clinical characteristics were comparable between the three groups. In all LVOs, median infarct volume was significantly smaller in the IA group compared to the untreated group (Abstract O-020 figure 1A, p=0.02) while infarct volume in the untreated and IV groups was similar (p=0.8). Based on level of occlusion, infarct volume was significantly smaller in the IA group compared to the untreated/IV group (Abstract O-020 figure 1B) in patients with terminal ICA (ICA-T) (p=0.005) and M1 MCA occlusions (p=0.02). Infarct volume in M2 occlusions was similar between the groups (p=0.3).ConclusionsEndovascular therapy for anterior circulation LVO appears to reduce infarct volumes in patients presenting within 8 h from symptom onset especially in ICA-T and M1 occlusions but not M2 occlusions. Prospective studies are needed to replicate these findings and correlate with clinical outcomes.Competing interestsNone.
P-020 Patterns of aneurysm recurrence following microsurgical clip obliteration: Abstract P-020 Figure 1
Authors: Spiotta A , Schuette A , Moskowitz S , Hui F 
Published: July 2012

IntroductionMicrosurgical clip obliteration remains a time-honored and viable option for the treatment of select aneurysms with very low rates of recurrence. We studied clipped aneurysms that were found to have recurrences to better understand the patterns and configuration of these rare entities.MethodsA retrospective review was performed of two prospectively maintained databases of aneurysm treatments from two institutions (Cleveland Clinic and Emory University) that spanned 14 years to identify patients with recurrent previously clipped intracranial aneurysms.ResultsTwenty-six aneurysm recurrences that were previously treated with clipping were identified. Three types of recurrence were identified; Type I proximal to the clip tines, Type II distal, and Type III lateral. The most common type of recurrence was that arising distal to the clip tines (46.1%) and the least frequency encountered recurrence was that arising proximal to the tines (19.2%) Laterally located recurrences were found in 34.6% of cases.ConclusionWe have described three different patterns of aneurysm recurrence with respect to the clip application and have identified three types; those occurring proximal, distal or lateral to the clip tines. However, it is not possible to discern which of these represent true aneurysm recurrences as opposed to incomplete initial treatments and subsequent enlargement of a residual. Further study of aneurysm recurrences would have to be performed in a prospective manner with closer scrutiny of microsurgically clipped aneurysms.Competing interestsA Spiotta: Integra Neurosciences, Hemedex. A Schuette: None. S Moskowitz: None. F Hui: None.Abstract P-020 Figure 1
P-022 Endovascular revascularization of carotid artery using a flow reversal device
Authors: Buciuc R , Luzardo G , Uschmann H 
Published: July 2012

IntroductionSurgical carotid revascularization has been described with various degrees of technical and clinical success. Currently, carotid revascularization is not recommended, based on the high potential for embolic stroke during the procedure. The data is however limited to only surgical cases. One series of endovascular revascularization for occluded carotids of unknown length of time has already been communicated. The authors present a similar series using a flow reversal device.MethodDuring the period of February 2009 to November 2011 a total of 13 patients underwent endovascular revascularization of either single or both occluded carotid arteries. The procedure was done in all cases using a flow reversal system (the Gore flow reversal) In three cases the procedure had to be aborted due to the fact that the occluded segment included part of the supraclinoid carotid. In the rest of cases the procedure was technically feasible succesfully. After revascularization all patients underwent stenting of their extracranial carotids. Two patients had either bilateral occlusions or presented with a non-disabling stroke due to a severe stenosis on one side and a chronic occlusion on the other. In these cases the revascularizations have been performed in stages with a 2–3 month interval in between interventions.ResultsThere were no neurologic complications related to the procedure either in the successful or in the aborted cases. Two patients developed large inguinal hematomas and had to be transfused.ConclusionThe endovascular revascularization of carotid artery occlusion of unknown duration is feasible using a flow reversal device. Addditional information regarding clinical and imaging indications for the procedure is necessary in order to proper select patients that might benefit. Long term follow-up will also be necessary in order to assess the viability of re-opened carotids as well as risks for stroke in patients after this procedure.Competing interestsNone.
P-023 3D venography in neurointerventional applications
Authors: Buciuc R 
Published: July 2012

Introduction3D venography has been reported previously as an indirect imaging method for visualization of various intracranial venous structures (ex.cavernous sinus). The potential disadvantage of indirect venography is the quality of imaging information which can have large variations and the need for an additional intervention should that be necessary. We present a direct transvenous modality of imaging intra- and extra-cranial venous structures.MethodA total of three patients have undergone direct 3D venography. Two of the patients had a venography for evaluation of cavernous venous structures and one patient was evaluated for a facial venous malformation. All patients underwent a direct injection of contrast within the structures to be imaged by a transvenous approach. A rotational venogram was performed and the raw data was postprocessed into 3D images. These were further analyzed. In two cases a transvenous intervention followed guided by the information obtained by direct 3D venography.ResultsAll patients underwent the study succesfully and without complications. In all cases the venography was essential in either guiding the following intervention or predicting the likelihood of venous bleeding intra-operativelly.Conclusions3D venography is a feasible technique with minimal added risks. The study can serve either as a guidance for further trans-venous interventions or as a predictor of intraoparative venous bleeding for trans-sphenoidal surgery.Competing interestsNone.
P-003 Baseline DWI volume predicts successful recanalization in multimodal endovascular therapy for acute ischemic stroke
Authors: Raychev R , Liebeskind D , Saver J , Hao Q , Vinuela F , Tateshima S , Jahan R , Gonzalez N , Szeder V , Cramer R , Balugde A , Rastogi S , Salamon N , Duckwiler G 
Published: July 2012

BackgroundEffective reperfusion is associated with better outcome from acute cerebral ischemia. The pre-intervention clinical and imaging predictors of procedural success in patients treated with multimodal mechanical device strategies (Merci ± Penumbra ± angioplasty and stenting) have not been well delineated.MethodsIn a prospectively maintained database, we analyzed consecutive patients with acute ICA and M1 occlusions treated with endovascular recanalization following MRI. We investigated the pretreatment clinical and imaging factors associated with substantial recanalization (TICI≥2b) and clinical outcome.ResultsAmong 105 patients meeting study entry criteria, mean age was 66.6 (±17.8). 65 % were female, median pretreatment NIHSS was 18 (range 2–31), mean baseline DWI volume was 30.6 cc (SD±35.1), and mean time to groin puncture was 412 min (SD±207.6). The median number of mechanical device passes was two (range 0–8). 73 (70%) patients were treated with a single device. IV tPA was used in 43 patients (41%). Substantial recanalization occurred in 43 patients (41%). The strongest predictors of poor outcome (mRS >3 at discharge) were high baseline NIHSS (OR 0.87; p<0.001) and presence of SAH after the procedure (OR 0.05; p=0.001). However, the presence of SAH did not correlate with the number of attempts or devices used. The strongest predictor of better outcome at discharge (mRS ≤3) was substantial recanalization (TICI≥2b). Time to groin puncture, number of device passes, single vs multiple device therapy, adjunctive IV TPA, or arterial occlusion site did not correlate substantial recanalization. In the final logistic regression multivariate analysis, among all baseline clinical and imaging variables considered, the pre-treatment DWI volume was the only factor associated with a substantial recanalization (OR 0.238; p=0.046).ConclusionsBaseline DWI lesion volume is a potent predictor of substantial reperfusion in multimodal endovascular therapy for acute ischemic stroke. This finding suggests that the effectiveness of the reperfusion therapy is likely influenced by much more complex pathophysiological mechanism, rather than mechanical and/or anatomical factors alone.Competing interestsNone.