bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Mediterranean diet is not associated with neuroimaging or cognition in middle‐aged adults: a cross‐sectional analysis of the PREVENT dementia programme
Authors: Gregory Sarah , Buller‐Peralta Ingrid , Bridgeman Katie , Góngora Vanessa De La Cruz , Dounavi Maria‐Eleni , Low Audrey , Ntailianis Georgios , O'Brien John , Parra Mario A. , Ritchie Craig W. , Ritchie Karen , Shannon Oliver M. , Stevenson Emma J. , Muniz‐Terrera Graciela 
Published: May 2024

AbstractBackground and purposeThe Mediterranean diet (MedDiet) has been associated with reduced dementia incidence in several studies. It is important to understand if diet is associated with brain health in midlife, when Alzheimer's disease and related dementias are known to begin.MethodsThis study used data from the PREVENT dementia programme. Three MedDiet scores were created (the Pyramid, Mediterranean Diet Adherence Screener [MEDAS] and MEDAS continuous) from a self‐reported food frequency questionnaire. Primary outcomes were hippocampal volume and cube‐transformed white matter hyperintensity volume. Secondary outcomes included cornu ammonis 1 and subiculum hippocampal subfield volumes, cortical thickness and measures of cognition. Sex‐stratified analyses were run to explore differential associations between diet and brain health by sex. An exploratory path analysis was conducted to study if any associations between diet and brain health were mediated by cardiovascular risk factors for dementia.ResultsIn all, 504 participants were included in this analysis, with a mean Pyramid score of 8.10 (SD 1.56). There were no significant associations between any MedDiet scoring method and any of the primary or secondary outcomes. There were no differences by sex in any analyses and no significant mediation between the Pyramid score and global cognition by cardiovascular risk factors.ConclusionsOverall, this study did not find evidence for an association between the MedDiet and either neuroimaging or cognition in a midlife population study. Future work should investigate associations between the MedDiet and Alzheimer's disease and related dementias biomarkers as well as functional neuroimaging in a midlife population.
Population‐based study of rare epilepsy incidence in a US urban population
Authors: Barbour Kristen , Tian Niu , Yozawitz Elissa G. , Wolf Steven , McGoldrick Patricia E. , Sands Tristan T. , Nelson Aaron , Basma Natasha , Grinspan Zachary M. 
Published: May 2024

AbstractObjectiveThis study was undertaken to estimate incidence of rare epilepsies and compare with literature.MethodsWe used electronic health record text search to identify children with 28 rare epilepsies in New York City (2010–2014). We estimated cumulative incidence and compared with literature.ResultsEight of 28 rare epilepsies had five or more prior estimates, and our measurements were within the published range for all. The most common were infantile epileptic spasms syndrome (1 in 2920 live births), Lennox–Gastaut syndrome (1 in 9690), and seizures associated with tuberous sclerosis complex (1 in 14 300). Fifteen of 28 had fewer than five prior estimates, and of these, we provided additional estimates for early infantile developmental and epileptic encephalopathy (1 in 32 700), epilepsy with myoclonic–atonic seizures (1 in 34 100), Sturge–Weber syndrome plus seizures/epilepsy (1 in 40 900), epilepsy in infancy with migrating focal seizures (1 in 54 500), Aicardi syndrome plus seizures/epilepsy (1 in 71 600), hypothalamic hamartoma with seizures (1 in 225 000), and Rasmussen syndrome (1 in 450 000). Five of 28 rare epilepsies had no prior estimates, and of these, we provided a new estimate for developmental/epileptic encephalopathy with spike‐and‐wave activation in sleep and/or continuous spikes and waves during sleep (1 in 34 100). Data were limited for the remaining 12 rare epilepsies, which were all genetic epilepsies, including PCDH19, CDKL5, Alpers disease, SCN8A, KCNQ2, SCN2A, GLUT1 deficiency, Phelan‐McDermid syndrome, myoclonic epilepsy with ragged‐red fibers, dup15q syndrome, ring chromosome 14, and ring chromosome 20.SignificanceWe estimated the incidence of rare epilepsies using population‐based electronic health record data and literature review. More research is needed to better estimate the incidence of genetic epilepsies with nonspecific clinical features. Electronic health records may be a valuable data source for studying rare epilepsies and other rare diseases, particularly as genetic testing becomes more widely adopted.
Modelling atopic dermatitis in healthy human skin for the characterization of topical compounds
Authors: Hacini‐Rachinel Feriel , Hauchard Alice , Bruno Sandro , Paulat Guido , Cojean Celine , Loesle Perrine , Schneider Martin Alexander , Bourne Marta , Elain Gaelle , Roth Lukas , Urban Beatrice , Viebrock Sabine , Leon Anette Orjuela , Röhn Till A. , Loesche Christian , Werfel Thomas , Thoma Gebhard , Zerwes Hans‐Günter 
Published: May 2024

AbstractSuitable human models for the development and characterization of topical compounds for inflammatory skin diseases such as atopic dermatitis are not readily available to date. We describe here the development of a translational model involving healthy human skin mimicking major aspects of AD and its application for the characterization of topical Janus kinase inhibitors. Full thickness human abdominal skin obtained from plastic surgery stimulated in vitro with IL4 and IL13 shows molecular features of AD. This is evidenced by STAT6 phosphorylation assessed by immunohistochemistry and analysis of skin lysates. Broad transcriptome changes assessed by AmpliSeq followed by gene set variation analysis showed a consistent upregulation of gene signatures characterizing AD in this model. Topical application of experimental formulations of compounds targeting the JAK pathway to full thickness skin normalizes the molecular features of AD induced by IL4 and IL13 stimulation. The inhibitory effects of topical JAK inhibitors on molecular features of AD are supported by pharmacokinetic analysis. The model described here is suited for the characterization of topical compounds for AD and has the potential to be extended to other inflammatory skin diseases and pathophysiological pathways.
Exploration of circulating metabolic signature of erythrodermic psoriasis based on LC‐MS metabolomics
Authors: Guo Lan , Wu Chao , Song Biao , Jin Hong‐Zhong 
Published: May 2024

AbstractErythrodermic psoriasis (EP) is a rare and life‐threatening disease, the pathogenesis of which remains to be largely unknown. Metabolomics analysis can provide global information on disease pathophysiology, candidate biomarkers, and potential intervention strategies. To gain a better understanding of the mechanisms of EP and explore the serum metabolic signature of EP, we conducted an untargeted metabolomics analysis from 20 EP patients and 20 healthy controls. Furthermore, targeted metabolomics for focused metabolites were identified in the serum samples of 30 EP patients and 30 psoriasis vulgaris (PsV) patients. In the untargeted analysis, a total of 2992 molecular features were extracted from each sample, and the peak intensity of each feature was obtained. Principal component analysis (PCA), orthogonal partial least squares‐discriminant analysis (OPLS‐DA) revealed significant difference between groups. After screening, 98 metabolites were found to be significantly dysregulated in EP, including 67 down‐regulated and 31 up‐regulated. EP patients had lower levels of L‐tryptophan, L‐isoleucine, retinol, lysophosphatidylcholine (LPC), and higher levels of betaine and uric acid. KEGG analysis showed differential metabolites were enriched in amino acid metabolism and glycerophospholipid metabolism. The targeted metabolomics showed lower L‐tryptophan in EP than PsV with significant difference and L‐tryptophan levels were negatively correlated with the PASI scores. The serum metabolic signature of EP was discovered. Amino acid and glycerophospholipid metabolism were dysregulated in EP. The metabolite differences provide clues for pathogenesis of EP and they may provide insights for therapeutic interventions.
Soutcom: Real‐time sentiment analysis of Arabic text for football fan satisfaction using a bidirectional LSTM
Authors: Alfarhood Sultan 
Published: May 2024

AbstractIn the last few years, various topics, including sports, have seen social media platforms emerge as significant sources of information and viewpoints. Football fans use social media to express their opinions and sentiments about their favourite teams and players. Analysing these opinions can provide valuable information on the satisfaction of football fans with their teams. In this article, we present Soutcom, a scalable real‐time system that estimates the satisfaction of football fans with their teams. Our approach leverages the power of social media platforms to gather real‐time opinions and emotions of football fans and applies state‐of‐the‐art machine learning‐based sentiment analysis techniques to accurately predict the sentiment of Arabic posts. Soutcom is designed as a cloud‐based scalable system integrated with the X (formerly known as Twitter) API and a football data service to retrieve live posts and match data. The Arabic posts are analysed using our proposed bidirectional LSTM (biLSTM) model, which we trained on a custom dataset specifically tailored for the sports domain. Our evaluation shows that the proposed model outperforms other machine learning models such as Random Forest, XGBoost and Convolutional Neural Networks (CNNs) in terms of accuracy and F1‐score with values of 0.83 and 0.82, respectively. Furthermore, we analyse the inference time of our proposed model and suggest that there is a trade‐off between performance and efficiency when selecting a model for sentiment analysis on Arabic posts.
Spatial and temporal variation of biomass density beneath drifting fish‐aggregating devices in the western and central Pacific Ocean
Authors: Zhang Tianjiao , Xin Jia , Song Liming , Yuan Hongchun 
Published: May 2024

AbstractWe analyzed three‐dimensional (3‐D) spatial and temporal variation of biomass density associated with drifting fish aggregating devices (dFADs) in the western and central Pacific Ocean. Detection depth of dFAD echosounder buoys was divided into three layers, for estimation of biomass density in each layer based on detected water volume. Temporal variation and spatial distribution of biomass density in each layer were compared. Similarity of biomass density gravity center shifts in each layer were assessed using the dynamic time warping (DTW) regularization algorithm. Biomass density varied regularly over ~1 month, with the 2nd and 3rd layers delayed ~14 days compared to the 1st layer. Biomass distribution range and density values were higher in the 1st layer than the 2nd and 3rd layers, but locations of maximum biomass density were close. The distribution of biomass density gravity centers between adjacent water layers were similar, with gravity centers of the 2nd and 3rd layers shifted over time in relationd to the 1st layer. Our study demonstrated that the aggregation behavior of species from different water layers attracted by dFADs were related, and emphasized the necessity for ecosystem‐based fisheries management.
Vonoprazan‐based therapies versus PPI‐based therapies in patients with H. pylori infection: Systematic review and meta‐analyses of randomized controlled trials
Authors: Liu Ligang , Shi Hekai , Shi Yufei , Wang Anlin , Guo Nuojin , Li Fang , Nahata Milap C. 
Published: May 2024

AbstractBackgroundThis study aims to evaluate the efficacy and safety of vonoprazan‐amoxicillin (VA), vonoprazan‐amoxicillin‐clarithromycin (VAC), vonoprazan‐based bismuth‐containing quadruple therapy (VBQT), and PPI‐based triple (PAC) or quadruple therapy (PBQT) for H. pylori infection with the consideration of duration of therapy and amoxicillin dose (H: high; L: low).Materials and MethodsPubMed, Embase, and the Cochrane Central Register of Controlled Trials were searched for eligible randomized controlled trials (RCTs) up to December 15, 2023. The efficacy outcome was eradication rate, and safety outcomes included the rates of adverse events and treatment discontinuation.ResultsTwenty‐seven RCTs were included. The pooled eradication rates were 82.8% for VA, 89.1% for VAC, and 91.8% for VBQT, which increased with the higher amoxicillin frequency of administration and extended duration of therapy within each regimen. There were no significant differences in eradication rate when comparing 7‐VA versus 7‐VAC and 14‐VA versus 14‐VAC. VA was at least comparable to PAC. The eradication rate did not differ significantly between 10‐H‐VA or 14‐H‐VA versus 14‐PBQT. 7‐L‐VAC demonstrated higher eradication rate versus 7‐PAC and comparable rate to 14‐PAC. 14‐VBQT showed higher eradication rates versus 14‐PBQT. The adverse events rate was 19.3% for VA, 30.6% for VAC, and 38.4% for VBQT. VA had similar risk of adverse events versus VAC and significantly fewer adverse events compared to PBQT. The treatment discontinuation rate did not differ significantly between treatments.ConclusionsThe eradication rate of VBQT was the highest at above 90% followed by VAC and VA. VA was as effective as VAC and superior to PPI‐based therapies with favorable safety, highlighting the potential of VA therapy as a promising alternative to traditional PPI‐based therapies. VPZ‐based triple or quadruple therapies was more effective than PPI‐based therapies. Further studies are needed to establish the optimal treatment regimen especially in the western countries.
Antifungal activity of Cinnamomum camphora essential oil against Fusarium oxysporum and its application on postharvest blueberry fruits preservation
Authors: Chen Kexin , Hu Zhenyang , Hu Jian , Tong Wenjun , Zhang Yushen , Du Lihui , Liu Fang 
Published: May 2024

SummaryPostharvest decay of blueberry fruits caused by Fusarium oxysporum (F. oxysporum) results in significant losses during logistics. To avoid chemical residue issues associated with synthetic fungicides, present study investigated the antifungal activity of Cinnamomum camphora essential oil (CEO) against Fusarium oxysporum (F. oxysporum) in postharvest blueberry fruits. CEO effectively disrupted cell membrane integrity, impaired ergosterol structure, restricted ATPase activity and inhibits mycelial growth. Blueberries treated with a 0.2% CEO‐based coating demonstrated improved overall sensory acceptability, enhanced firmness, increased total soluble solids and titratable acidity, and reduced decay rate. CEO also decreased malondialdehyde contents while promoting ascorbic acid and glutathione levels and activating antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), and peroxidase (POD), maintaining cell membrane structure and enhancing resistance against F. oxysporum infection. The findings suggest that CEO serves as an eco‐friendly agent for mitigating primary fungal invasion in blueberries during postharvest storage.
Comparing the nutritional composition and antioxidant properties of an Australian native grain variety with commonly consumed wheat
Authors: Williams Luke B. , Birch Jacob , Zakaria Rosita , Nguyen Hao , Itsiopoulos Catherine , Wright Paul F.A. 
Published: May 2024

SummaryClimate change is threatening our current food systems and countries around the world are seeking alternative food sources to safeguard against potential food insecurity and nutrient deficiency concerns. Various traditional foods used by Aboriginal groups of Australia have previously been shown to be highly nutritious, contain beneficial functional properties and can thrive in the harsh climatic conditions found across Australia. As interest in these traditional foods grows, Aboriginal groups are looking at developing a range of foods for modern markets. However, for many of these foods, there is still little known about their nutritional and functional properties. In this study, we report the nutrition composition and antioxidant properties of a native Australian grain species that is currently being developed for commercial markets by a collective of Aboriginal Traditional Custodians and compare its properties to a commonly consumed wheat variety. Compared with wheat, the native grain species contained 2‐fold greater protein and total fats, and higher levels of essential minerals and trace elements, including 8‐fold iron levels and >2.5‐fold calcium, magnesium, zinc, copper and manganese levels. Functionally, the native grain contained 2.4‐fold greater polyphenol content and displayed greater antioxidant potential in exposed human monocyte cultures. Importantly, the native grain was also found to contain a very low gluten content. Altogether, this shows that the native grain is nutritionally and functionally superior to commonly consumed wheat for the measured parameters and could potentially serve as a grain alternative or be used to fortify current wheat‐based and gluten‐free products.
Combined effect of oligosaccharides combination on the growth of probiotics: synergistic or superposable?
Authors: Zhang Congchun , Kang Wenli , Han Yifeng , Li Yisi , Yang Renqin , Huang Yujun , Pan Lina , Yin Boxing , Wang Jiaqi , Li Wei , Gu Ruixia , Ma Wenlong 
Published: May 2024

SummarySynbiotics confer benefits to our health. Study on the promotion effects of prebiotics combinations on probiotics growth is necessary for synbiotics preparation. However, there exists few reports on how to combine different prebiotics. The aim of the study was to explore combined effect of prebiotics combinations in modulating probiotics growth for rational synbiotics development. Four prebiotic oligosaccharides were screened for their promotion effects on the growth of four representative probiotics. Then, SynergyFinder 3.0 was used for the first time to rationally analyse interaction of various oligosaccharides combinations. Results showed that there was no synergism between any of two oligosaccharides under the conditions studied, but rather a superposition effect. Finally, the optimal oligosaccharides combinations based on the maximum specific growth rate and the maximum cell yield were selected. This study advanced our knowledge of oligosaccharides utilisation by probiotics and provided guidance on the rational selection of oligosaccharides combinations for specific probiotics, which was important for the design of synergistic synbiotics.
Screening for alkaliphilic microalgae for carbon capture from ambient air and food production
Authors: Villaró‐Cos Silvia , García‐González Jesús , Lafarga Tomás 
Published: May 2024

SummaryThe production of alkaliphilic microalgae can contribute to address the challenging cost of using pure carbon dioxide in large reactors. At high pH values, carbon dioxide is rapidly scavenged and the supply rates of dissolved inorganic carbon from the atmosphere to alkaline media are high. The present study aimed to identify microalgal strains that can cope with high alkalinity and aeration rates. Eight strains were studied and the microalgae Chlorella vulgaris, Scenedesmus almeriensis and Nannochloropsis gaditana were the only ones that were able to grow under these conditions. Their biomass productivities using laboratory‐scale bubble columns with no pH control and high aeration flow were 0.20 ± 0.03, 0.24 ± 0.03 and 0.08 ± 0.01 g·L−1·day−1, respectively. The production of the two former was scaled up to pilot‐scale bubble columns. Overall, the amount of atmospheric carbon dioxide that was transformed into biomass was in the range of 10%–30%, depending on the strain used and the photobioreactor setup. The biomass was rich in proteins and β‐carotene, both valuable products, highlighting the potential production of food ingredients while capturing carbon dioxide from the atmosphere.
Freeze drying and spray drying for the retention of the active components, L‐theanine and caffeine, and antioxidant activity of tea‐based ingredients
Authors: Allameh Mina , Orsat Valérie 
Published: May 2024

SummaryPreserving food products from oxidation improves their quality and stability. This study compares the effects of storage on L‐theanine, caffeine, moisture content and antioxidant activity of spray‐dried and freeze‐dried white tea infusions. The antioxidant activities of both dried infusions were restored over a 60‐day storage. On Day 60, the L‐theanine and caffeine levels of the freeze‐dried samples were respectively 1.45 ± 0.03 mg mL−1 and 2.23 ± 0.04 mg mL−1 compared with 1.16 ± 0.03 mg mL−1 and 1.97 ± 0.01 mg mL−1 on Day 0. In the spray‐dried samples, the L‐theanine was 0.32 ± 0.01 mg mL−1 on Day 60 and 0.36 ± 0.02 mg mL−1 on Day 0, while caffeine remained unchanged. Regarding undried/control samples, L‐theanine and caffeine declined from respectively 0.29 ± 0.0004 mg mL−1 and 0.33 ± 0.01 mg mL−1 on Day 0 to 0.2 ± 0.001 mg mL−1 and 0.26 ± 0.02 mg mL−1 on Day 60, associated with a decrease in DPPH activity from 75.87% (Day 0) to 15.34% (Day 60). Freeze‐drying and spray‐drying tea infusions yielded functional products with stable antioxidant activity and moisture. Both drying techniques are reliable for preserving tea preparations.
Noodles made from blends of rice flour and pineapple stem starch: physical properties, cooking qualities, in vitro starch digestibility and sensory properties
Authors: Pinyo Jukkrapong , Wongsagonsup Rungtiwa , Boonsanong Natt , Hongsanyatham Sornsawan , Somprasong Natdanai , Khunoad Phirata , Suphantharika Manop , Smith Siwaporn Meejoo , Amornsakchai Taweechai 
Published: May 2024

SummaryNoodles are generally made from rice flour, wheat flour or mungbean starch. Interestingly, pineapple stem starch (PSS), an alternative starch derived from pineapple stems as agricultural waste, has not yet been investigated for noodle production. The noodles were then prepared in different ratios of commercial rice flour and PSS (100:0, 70:25, 50:50, 25:75 and 0:100) to investigate the effects of PSS on noodle qualities and properties including physical properties, cooking quality, in vitro starch digestibility and sensory attributes. The results showed that high PSS content had a positive effect on the structure and textural properties of noodles by increasing the network structure, hardness and chewiness, resulting in good sensory quality, which could be due to the high amylose content (30.56%) of PSS. However, the optimal cooking time and the cooking loss of the cooked noodles increased with an increasing proportion of PSS. In addition, noodles with a high PSS content had a higher content of slowly digestible starch and resistant starch, which can have a positive effect on our health. Our results suggest that PSS, an alternative starch from agricultural waste, can replace rice flour to develop better‐quality gluten‐free noodles. Similarly, PSS‐based noodles with a high resistant starch content could benefit human health by lowering the glycemic index and reducing the risk of non‐communicable diseases.
Et nous? Étude par vignettes expliquant les préférences en matière de formation par le type de contrat et la nature des compétences visées
Authors: KOSTER Ferry 
Published: May 2024

RésuméL'auteur présente une expérimentation par vignettes sur les préférences des travailleurs en matière de formation aux Pays‐Bas. S'appuyant sur la théorie du capital humain, la théorie du signal et la thèse de la «nouvelle relation d'emploi», il postule que ces préférences dépendent du type de compétences ciblées par la formation et du type de contrat de travail. Ses résultats confirment cette hypothèse et indiquent que les salariés permanents ont certes une préférence relative plus forte pour l'acquisition de compétences spécifiques à une organisation que les travailleurs temporaires ‐ qui privilégient l'enrichissement de leurs compétences générales ‐, mais que les travailleurs dans leur ensemble préfèrent la formation ciblant les compétences générales. L'article révèle aussi que les travailleurs temporaires se forment moins qu'ils le souhaiteraient.