bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘Making a difference’: a national pilot study bringing together four agencies to develop a model which enables the identification, treatment and support of children/young people with mental health problems in secondary education
Authors: Macdonald K. , O'Connor P. , Patrick M. , Robinson M. 
Published: October 2010

The project aims to create a process model for dealing with mental health issues within secondary education. This will be achieved by creating clearer and more efficient pathways into appropriate care and equipping staff with the knowledge and skills to enable fast referral or to support young people within the educational institution.Initial components of the project include meeting with key individuals in schools, college and community to identify core issues in relation to the mental health of young people. Service mapping: youth services/projects within the city which may impact or be an added resource to the project through partnership working. Planning and delivery of training package (cascade model) to school/college staff. Development of a mental health promotion programme in partnership with NHS Mental Health Promotion Department. Development of referral procedures: mental health practitioner and educational psychologists attending in school resource meetings in consultancy capacity with referral onto appropriate agency if necessary. Piloting of referral and screening tools within educational establishments. Progress of the above as well as current and future developments will be discussed.
Early intervention in psychosis: comparison of individuals receiving a specialized first episode service with those receiving treatment as usual
Authors: Macdonald K. , Blackburn P. , Jarmen R. 
Published: October 2010

This study was made possible due to the merger of two Trusts 2 years ago. The Early Intervention Project (EIP) was developed in East Yorkshire which is a largely rural setting with the exception of Bridlington which has many of the problems associated with urban areas. Individuals in the project were matched with young people in Hull who had been receiving treatment as usual. Participants were compared with information gathered from patient records and interviews with clients and relatives.Preliminary results are encouraging. One of the most striking outcomes was employment (42% of EIP clients unemployed compared with 100% of the TAU group). TAU clients were more likely to have presented to services previously and been discharged (TAU 41.7%, EIP 15.8%). Readmission rates – EIP 15.8%, TAU 58.3%. Qualitative feedback revealed generally high praise for the EIP project with the exception of experiences of in‐patient units. This was reflected in both groups and represents an area which needs urgent attention. There were clear differences in the service each group received which was reflected both in outcome and satisfaction. The project is currently being extended across the integrated trust.
Working in partnership – developing a young people's service in a rural environment
Authors: Mitchell M. , Cogan M. , Clegg C. 
Published: October 2010

Specific objective  The Project reviewed – The Provision of Services for Early Psychosis in Cornwall. It looked at staff feedback, user and carers' views, base line assessment and National Guidelines of Best Practice, and proposed significant changes to meet the needs of young people.Method  The Review was carried out under the auspices of the National Clinical Governance Team and used as its framework the RAID model of change.Results  This resulted in a series of recommendations, which informed new developments. Current initiatives include a Health Promotion Programme, Training Strategies in Primary Care and effective partnerships with young people's services.Conclusions  It proposes significant changes to the correct system of care by working outside the traditional healthcare settings and across the service boundaries of health, education and social care. The rurality of Cornwall provides a considerable challenge for service delivery. This review ensured that ownership rested with users, careers, staff and others who contributed and shaped its future direction.
Quetiapine treatment in early psychosis: 1 year outcomes
Authors: Kopala L. , Woodley H. , Campbell L. A. , Gallant J. , Rui Q. , Milliken H. , Whitehorn D. 
Published: October 2010

Objective  To determine clinical response, dosing and adverse events associated with quetiapine treatment in early psychosis.Method  40 Patients (33 men; 7 women; mean age 23.75) with schizophrenia spectrum disorders and less than 6 months previous exposure to antipsychotic treatment, entered an open label, 2 years, flexible dose trial and were assessed with PANSS, CGI, GAF, SOFAS, ESRS, BMI and ocular exams at baseline and 6 month intervals thereafter.Results  Among 30 patients who enrolled >1 years ago, 19 (63%) completed 1‐year assessment. Dropouts were due to insufficient clinical response (13%), nonadherence (13%) and personal choice (10%). At 1 year, significant improvement was observed on the PANSS, CGI, GAF and SOFAS. Mean dose was 559 (±207) mg/day. No drug induced EPS was noted and EPS present at baseline was reduced. Mean change in BMI was 17% (±22). No ocular changes were observed.Conclusions  Quetiapine was well tolerated. Clinical response was similar to that achieved with other second generation antipsychotic agents in the same early psychosis programme.
Insight in early psychosis: a 1 year follow‐up
Authors: Mintz A. , Addington J. , Addington D. 
Published: October 2010

Insight is an important prognostic indicator in early psychosis, as its presence can enhance treatment compliance, thus reducing the risk of clinical deterioration. The Calgary Early Psychosis Programme (EPP) is a comprehensive treatment programme for individuals experiencing their first episode of psychosis.Purpose  (i) to examine insight on admission and determine if change occurred in the first year of treatment and (ii) to determine if insight was associated with other symptoms.Methods  Participants were 180 consecutive admissions to EPP who completed a 1‐year follow‐up. Insight, positive and negative symptoms were measured with the PANSS. Depression was measured with the Calgary Depression Scale.Results  There was a significant improvement in insight from initial to 1‐year follow‐up (P < 0.001). Insight was positively correlated with positive and negative symptoms (P < 0.001) over time. Insight was negatively correlated with depression (P < 0.001) at the initial assessment.Conclusions  In these first episode patients, there is a significant improvement in insight over time. Insight is significantly related to positive and negative symptoms and to depression in the initial stages of the illness when the presence of depression is notable.
Changes in appearance related to psychopathology
Authors: Campo J. M. L. G. Á. , Hardy S. L. C. , Merckelbach H. L. G. J. 
Published: October 2010

Objective  To determine whether changes in appearance can be seen as optional symptoms of (early) psychosis.Method  Psychiatric patients from different diagnostic categories were being screened at the incidence of changes inappearance. The categories differed from each other to the degree in which psychotic symptoms are part of the psychopathology. The following diagnostic categories were included: schizophrenia; borderline personality disorder and mood disorders without psychotic symptoms. The study also included healthy controls. Factors related to the changes in appearance were also investigated. To investigate the relationships self‐report questionnaires were used.Results  The Results so far (the study will be completed in May of this year) indicate that changes in appearance have the highest incidence in the schizophrenic subjects. For the healthy controls, psychosis‐proneness correlates with changes in appearance. Factors related to the changes are body image disorders and loss of identity.Conclusion  Changes in appearance can be seen as optional symptoms of (early) psychosis.
First‐episode psychotic patients: differences in self‐rating and relatives' rating of premorbid personality traits
Authors: Neury D. , Panhuber I. , Merlo M. C. G. 
Published: October 2010

Objectives  The purpose of this study is to evaluate differences in self‐rating and relatives' rating of premorbid personality traits of first‐episode patients and to look for its predictive value in early course of psychopathology. The implications of the differences in these ratings on Quality of Life after a follow‐up and on psychotherapeutic approach are also considered.Methods  The Munich Personality Test was applied to patients and to one of their relatives. BPRS was also used as well as the Quality of Life interview of Lehman to measure social integration.Results  We found significant differences between the self‐rating and the relatives' rating. These differences were more marked in patients who had less than 25% improvement of positive symptoms during the first week. These patients also scored lower on Quality of Life at 1‐year follow‐up. The differences in perception of premorbid personality traits may have a relation with slower improvement of psychopathology during treatment of the first episode of psychosis. Interestingly, there was a difference in Quality of Life scores even 1 year after first hospitalization.
Psychological testing and retesting of first‐episode psychotics
Authors: Lorentzen P. , Andersen P. B. , Munkner R. , Knudsen P. 
Published: October 2010

Objective  To compare psychological test and retest results of 34 first‐episode psychotic patients.Material  Patients included in ‘The Danish National Schizophrenia Project’.Method  Six WAIS‐R subtests (Information, Vocabulary, Similarities, Picture Completion. Picture Arrangement, Block Design) and the Rorschach Test according to Exner's Comprehensive System (CNS) were given to the patient shortly after admission and 2 years later.Results  Preliminary results from the retest show higher scores on the six WAIS‐R subtests, but no corresponding positive difference in the cognitive findings on the Rorschach Test.Conclusion  Cognitive functions tested by WAIS‐R and Rorschach, respectively, need to be examined further.
Biostratigraphy and assigning the paleosalinity by using Echinocorys and Planktonic foraminifera at Upper Maastrichtian, in Jorband section, Central Alborz, Iran
Authors: Asgharian Rostami Masood , Balmaki Behnaz , Shafiee Ardestani Meysam , Kohansal Esmail 
Published: October 2010

AbstractJorband section is located in the north slope of central Alborz, and 28 Km south of Noor. It has been sampled and index fossilic groups of planktonic foraminifera and echinoids were studied in order to assign the paleosalinity and biozonation in central Alborz. The planktonic foraminiferal biozones identified within the Upper maastrichtian sequence of the Jorband section are three zones of Contustruncana contusa, Planoglobulina brazoensis, and Racemiguembelina fructicosa. The salinity changes were also searched in this section. In three layers in Jorband section examination echinocorys genus and is drawn as a diagram which in middle of the section, the salinity mounts is fewer than the beginning and top of the section.
Electron microscopy analysis of FcRγ localization after its capture by T cells by trogocytosis
Authors: Balor Stephanie , Daëron Marc , Bruhns Pierre , Hudrisier Denis 
Published: October 2010

AbstractT cells acquire various proteins from their cellular partners by the process of trogocytosis. We recently demonstrated that the FcγRIIIA receptor and its associated FcRγ are captured by T cells during their co-culture with FcγR-expressing target cells upon both antigen- or antibody-mediated stimulation. Interestingly, we found that FcR captured by T cells could bind ligands but did not transmit detectable intracellular signals or signaling-depending functions upon ligand binding suggesting their improper integration in the recipient T cell membrane. In this study, we provide morphological data in support of this hypothesis. Indeed, we show that the FcRγ-subunit, which we used as a fusion to GFP, was clearly present at the plasma membrane of donor cells, but was detected within structures that were in close contact of, but apparently not integrated in, the plasma membrane of recipient T cells.
Remarks on the number of tubulin dimers per neuron and implications for Hameroff-Penrose Orch OR
Authors: Georgiev Danko 
Published: October 2010

AbstractStuart Hameroff has wrongly estimated that a typical brain neuron has 10^7^ tubulin dimers and wrongly attributed this result to Yu and Baas, J. Neurosci. 1994; 14: 2818-2829. In this letter we show that Hameroff’s estimate is based on misunderstanding of the results provided by Yu and Baas, who actually measured the total microtubule length in a single axonal projection with length of 56 μm in a differentiating in vitro stage 3 embryonic hippocampal neuron. In order to visualize how big Hameroff’s error is, we have reconstructed two of the studied by Yu and Baas embryonic hippocampal neurons with Neuromantic v1.6.3 and compared them with previously published reconstructions of adult hippocampal neurons. Correct calculations show that an adult differentiated pyramidal neuron in vivo has approximately 1.3 × 10^9^ tubulin dimers incorporated in cytoskeletal microtubules. This estimate has profound implications for the Hameroff-Penrose Orch OR model, because it sets limitations on the number of quantum coherent neurons and implies that if 100% of the neuronal microtubules are quantum coherent for 25 ms then Hameroff-Penrose Orch OR conscious events should involve only 15 pyramidal neurons.
The INCF Digital Atlasing Program: Report on Digital Atlasing Standards in the Rodent Brain
Authors: Ng Lydia , Zaslavsky Ilya , Nissanov Jonathan , Puelles Luis , Ruffins Seth , Hawrylycz Michael , Boline Jyl , Burger Albert , Hashikawa Tsutomu , Johnson G. Allan , Verbeek Fons , Martone Maryann 
Published: October 2010

AbstractThe goal of the INCF Digital Atlasing Program is to provide the vision and direction necessary to make the rapidly growing collection of multidimensional data of the rodent brain (images, gene expression, etc.) widely accessible and usable to the international research community. This Digital Brain Atlasing Standards Task Force was formed in May 2008 to investigate the state of rodent brain digital atlasing, and formulate standards, guidelines, and policy recommendations.Our first objective has been the preparation of a detailed document that includes the vision and specific description of an infrastructure, systems and methods capable of serving the scientific goals of the community, as well as practical issues for achieving the goals. This report builds on the 1st INCF Workshop on Mouse and Rat Brain Digital Atlasing Systems (Boline et al., 2007, Nature Preceedings, doi:10.1038/npre.2007.1046.1) and includes a more detailed analysis of both the current state and desired state of digital atlasing along with specific recommendations for achieving these goals.
Systems Biology Graphical Notation: Entity Relationship language Level 1
Authors: Le Novère Nicolas , Moodie Stuart , Sorokin Anatoly , Schreiber Falk , Mi Huaiyu 
Published: October 2010

AbstractStandard graphical representations have played a crucial role in science and engineering throughout the last century. Without electrical symbolism, it is very likely that our industrial society would not have evolved at the same pace. Similarly, specialised notations such as the Feynmann notation or the process flow diagrams did a lot for the adoption of concepts in their own fields. With the advent of Systems Biology, and more recently of Synthetic Biology, the need for precise and unambiguous descriptions of biochemical interactions has become more pressing. While some ideas have been advanced over the last decade, with a few detailed proposals, no actual community standard has emerged. The Systems Biology Graphical Notation (SBGN) is a graphical representation crafted over several years by a community of biochemists, modellers and computer scientists. Three orthogonal and complementary languages have been created, the Process Descriptions, the Entity Relationships and the Activity Flows. Using these three idioms a scientist can represent any network of biochemical interactions, which can then be interpreted in an unambiguous way. The set of symbols used is limited, and the grammar quite simple, to allow its usage in textbooks and its teaching directly in high schools. The first level of the SBGN Entity Relationship language has been publicly released. Shared by the communities of biochemists, genomicians, theoreticians and computational biologists, SBGN languages will foster efficient storage, exchange and reuse of information on signalling pathways, metabolic networks and gene regulatory maps.
Performance of the ALOGPS 2.1 program for octanol-water partition coefficient prediction with organic chemicals on the Canadian Domestic Substances List
Authors: Rayne Sierra , Forest Kaya 
Published: October 2010

AbstractThe KOWWIN and ALOGPS octanol-water partition coefficient (K~ow~) estimation software programs were compared for their capacity to accurately predict log K~ow~ values of 1545 organic compounds on the publicly available Domestic Substances List (DSL) from Environment Canada for which experimental data is available. Approximately equivalent log K~ow~ error statistics were observed between KOWWIN and ALOGPS against available experimental data. Substantial predictive differences were observed between the two programs for 6529 compounds not having experimental K~ow~ data on the Canadian DSL. Predictive differences of up to 40 log K~ow~ units were found between KOWWIN and ALOGPS, and in some cases, the discrepancies were sufficiently large that strongly opposing hydrophobicity classifications were obtained.
Signaling Flux Redistribution concept can switch survival to apoptosis in cancer cells
Authors: Yamada Daiki , Hayashi Kentaro , Piras Vincent , Tomita Masaru , Tsuchiya Masa , Selvarajoo Kumar 
Published: October 2010

AbstractThe tumor necrosis factor related apoptosis-inducing ligand (TRAIL) induces apoptosis in certain types of carcinoma. However, in majority of malignant tumors, it has no effect. Here we analyzed cell survival and apoptotic pathways triggered by TRAIL. A computational model based on perturbation-response approach with mass-action equations was developed. All 48 parameter values of the model were selected by genetic algorithm that minimizes deviation between experimental and simulation data for human fibrosarcoma cells. Subsequently, we show in silico knock-down of a cell survival pathway molecule could potentially enhance the activation of apoptosis through Signaling Flux Redistribution (SFR).
Thermal characterization of Plasmodium falciparum species specific proteins in Indian geographical area.
Authors: Bhardwaj Mohit , Bharadwaj Leena , Trigunayat Kritika , Trigunayat Madan Mohan 
Published: October 2010

AbstractThe paper reveals thermal characteristics of P.falciparum species specific proteins. These proteins determine why P. vivex species are dominant over P.falciparum in Indian geographical area. Outside human host plasmodium parasite survives in poikilothermal mosquitoes. Climatic temperature conditions greatly affect native state of P.falciparum species specific proteins in mosquitoes. Study of climatic temperature conditions in Indian geographical area reveals that Pfsd protein for Plasmodium falciparum can remain in native state between &8805;7 degree centigrade and &8804;42.6 degree centigrade temperature conditions. While their best optimum functions (activity) was noted between 25.3 degree centigrade to 33degree centigrade. Pfsd protein were found more heat susceptible for temperature minima and maxima than Pvsd proteins of P. vivex causing all time high population ratio of P.falciparum species.
Annual population rhythm of Anopheles mosquitoes in Indian subcontinent
Authors: Bhardwaj Mohit , Bharadwaj Leena , Trigunayat Kritika , Trigunayat Madan Mohan 
Published: October 2010

AbstractSeveral organism show a rhythm based behavior in their life. Mosquitoes are surviving successfully since ancient time on earth while lots of biological creatures have been extinct. Thus it is interesting to study their population load. Climatic conditions affect mosquito population significantly so on the basis of malaria cases their population is estimated in present study in Indian geographical scenario. In this study it was found that their annual population load show a scientific rhythm. A schematic wave form representation is also presented here to show mosquito population load. This study will be helpful in malaria vector eradication and health care policies.
Community content building for evolutionary biology: Lessons learned from LepTree and Encyclopedia of Life
Authors: Parr Cynthia , Campbell Dana , Park John 
Published: October 2010

AbstractOnline resources to aid large-scale ecological and evolutionary biology are beginning to take root, only a decade behind fields such as genomics and molecular biology. One barrier has been a long tradition, in evolutionary biology at least, of work by individuals on the order of a few hundred of species rather than the thousands or hundreds of thousands necessary to understand the general evolutionary or ecological processes that explain species characteristics and distributions. Advances in collaborative and semantic software offer promise – it should be possible to develop high quality online species-level datasets for comparative analyses and even to integrate, via machine reasoning, across highly customized datasets. In this talk we will compare and contrast two approaches to assembling the data.
The Teleost Taxonomy Ontology
Authors: Midford Peter , Balhoff James , Dahdul Wasila , Kothari Cartik , Lapp Hilmar , Lundberg John , Mabee Paula , Vision Todd , Westerfield Monte 
Published: October 2010

AbstractThe Teleost Taxonomy Ontology (TTO) is an ontology of taxonomic groups and associated names for fish (not just teleosts). This ontology has served as a source of names and taxonomic structure within the Phenoscape project since early 2008. Although the TTO is based on Eschmeyer's Catalog of Fishes (CoF) and incorporates all valid species and genus names, it is also extended by the curation needs of the Phenoscape project. Names of fossil taxa not included in the CoF as well as references to specimens identi*ed only to genus (e.g., Eigenmannia sp. (Fink and Fink 1981)) are incorporated into the TTO as required by the curation needs of the Phenoscape project. As Phenoscape receives updates to the CoF, a tool called TTOUpdate merges the changes into the TTO.