bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comorbidities of chronic rhinosinusitis in children and adults
Authors: Murtomäki Aada , Helevä Alma , Torkki Paulus , Haukka Jari , Julkunen‐Iivari Anna , Lemmetyinen Riikka , Mäkelä Mika , Dietz Aarno , Nuutinen Mikko , Toppila‐Salmi Sanna 
Published: April 2024

AbstractBackgroundChronic rhinosinusitis (CRS) is a chronic inflammatory disease of the nose and paranasal sinuses lasting ≥12 weeks. CRS may exist with (CRSwNP) or without (CRSsNP) nasal polyps. The aim was to evaluate conditions associated with CRS in a randomized hospital cohort. We hypothesized that comorbidities and surgical procedures differ between pediatric and adult patients.MethodsThis study consisted of hospital registry data of a random sample of rhinosinusitis patients (age range 0–89 years) with the diagnosis of J32 or J33, correspondingly, registered during outpatient visits from 2005 to 2019 (n = 1461). The covariates of interest were collected from electronic health records based on ICD‐10 codes and keyword searches.ResultsAmong pediatric patients (n = 104), the relative proportions of CRSsNP and CRSwNP were 86% and 14% respectively. The relative proportions of adult patients (n = 1357) with CRSsNP and CRSwNP were 60% and 40%, respectively. The following comorbidities significantly differed (p < 0.05) between pediatric and adult populations: allergy, chronic otitis media, and tonsillar diseases. In total, 41 % of the children and 46% of the adults underwent baseline endoscopic sinus surgery (ESS). Additional surgeries of the ear, nose and pharynx were significantly more common among children compared with adults. Risk of revision after baseline ESS was associated (p < 0.05) with allergy, asthma, eosinophilia, CRSwNP, immunodeficiency or its suspicion, non‐steroidal anti‐inflammatory drug exacerbated respiratory disease, and number of any diseases ≥2.ConclusionsOur study showed that comorbidities differ between pediatric and adult rhinosinusitis patients, as allergy, asthma and allergy, chronic otitis media, mental health disorders, and tonsils disease were significantly more prevalent among pediatric patients. Children and adults were equally treated with ESS. Notably, children underwent additional surgery on adenoids and tonsils more frequently. The effectiveness of ESS in multimorbid adults should be assessed at an individual level.
Disparities in clinical trial enrollment at a Canadian comprehensive cancer center: A 15‐year retrospective study
Authors: Shapiro Gilla K. , Santiago Anna T. , Pittman Tyler , Iwano Kai , Rodin Gary , Cole Heather , Zeman Katherine , Sellmann Susanna , Oza Amit M. , Jones Jennifer , Rosenthal Meredith , Conti Rena M. , Rodin Danielle 
Published: April 2024

AbstractIntroductionDisparities in clinical trials (CTs) enrollment perpetuate inequities in treatment access and outcomes, but there is a paucity of Canadian data. The objective of this study was to examine disparities in cancer CT enrollment at a large Canadian comprehensive cancer center.MethodsRetrospective study of CT enrollment among new patient consultations from 2006 to 2019, with follow‐up to 2021 (N = 154,880), with the primary outcome of enrollment as a binary variable. Factors associated with CT enrollment were evaluated using multivariable Bayesian hierarchical logistic regression with random effects for most responsible physician (MRP) and geography, adjusted for patient characteristics (sex, age, language, geography, and primary care provider [PCP]), area‐level marginalization (residential instability, material deprivation, dependency, and ethnic concentration), disease (cancer site and stage), and MRP (department, sex, language, and training). A sensitivity analysis of the cumulative incidence of enrollment was conducted to account for differences in disease type and follow‐up length.ResultsCT enrollment was 11.2% overall, with a 15‐year cumulative incidence of 18%. Lower odds of enrollment were observed in patients who were female (adjusted odds ratio [AOR], 0.82; 95% confidence interval [CI], 0.78–0.86), ≥65 years (AOR vs. <40, 0.61; 95% CI, 0.56–0.66), non‐English speakers (0.72; 95% CI, 0.67–0.77), living ≥250 km away (AOR vs. <15 km, 0.71; 95% CI, 0.62–0.80), and without a PCP. Disease characteristics accounted for the largest proportion of observed variation (20.8%), with significantly greater odds of enrollment in patients with genitourinary cancers and late‐stage disease.ConclusionSignificant sociodemographic disparities were observed, suggesting the need for targeted strategies to increase diversity in access to cancer CTs in Canada.
Unhealthy lifestyle behaviors, overweight, and obesity among childhood cancer survivors in the Netherlands: A DCCSS LATER study
Authors: Bouwman Eline , Penson Adriaan , de Valk Maud , van den Oever Selina R. , van der Pal Helena J. H. , van Dulmen‐den Broeder Eline , Blijlevens Nicole M. A. , Bresters Dorine , Feijen Elizabeth A. M. , van den Heuvel‐Eibrink Marry M. , van der Heiden‐van der Loo Margriet , Michel Gisela , Ronckers Cécile M. , Teepen Jop C. , Tissing Wim J. E. , Versluys Birgitta A. B. , Kremer Leontien C. M. , Pluijm Saskia M. F. , Loonen Jacqueline J. ,   the Dutch LATER Study Group and the PanCareFollowUp Consortium
Published: April 2024

AbstractBackgroundThe objective of this study was to examine the prevalence of unhealthy lifestyle behaviors, overweight, and obesity in Dutch childhood cancer survivors (CCSs) compared with sibling controls and the Dutch general population. Other aims were to assess associated factors of unhealthy lifestyle behaviors, overweight, and obesity and to identify subgroups of CCSs at risk for these unhealthy statuses.MethodsThe authors included 2253 CCSs and 906 siblings from the Dutch Childhood Cancer Survivor Study‐Late Effects After Childhood Cancer cohort, part 1, and added data from the Dutch general population. Questionnaire data were collected on overweight and obesity (body mass index >25.0 kg/m2), meeting physical activity guidelines (>150 minutes per week of moderate or vigorous exercises), excessive alcohol consumption (>14 and >21 alcoholic consumptions per week for women and men, respectively), daily smoking, and monthly drug use. Multivariable logistic regression analyses and two‐step cluster analyses were performed to examine sociodemographic‐related, health‐related, cancer‐related, and treatment‐related associated factors of unhealthy lifestyle behaviors and to identify subgroups of CCSs at risk for multiple unhealthy behaviors.ResultsCCSs more often did not meet physical activity guidelines than their siblings (30.0% vs. 19.3%; p < .001). Married as marital status, lower education level, nonstudent status, and comorbidities were common associated factors for a body mass index ≥25.0 kg/m2 and insufficient physical activity, whereas male sex and lower education were shared associated factors for excessive alcohol consumption, daily smoking, and monthly drug use. A subgroup of CCSs was identified as excessive alcohol consumers, daily smokers, and monthly drug users.ConclusionsThe current results emphasize the factors associated with unhealthy behaviors and the potential identification of CCSs who exhibit multiple unhealthy lifestyle behaviors.
Limited efficacy of 3 + 7 plus gemtuzumab ozogamycin in newly diagnosed fit intermediate genetic risk acute myeloid leukemia patients
Authors: Serio Bianca , Grimaldi Francesco , Ammirati Lucia , Annunziata Mario , De Santis Giovanna , Perrotta Alessandra , De Novellis Danilo , Giudice Valentina , Morini Denise , Storti Gabriella , Califano Catello , Risitano Antonio Maria , Pane Fabrizio , Selleri Carmine 
Published: April 2024

AbstractBackgroundGemtuzumab‐ozogamycin (GO) is approved in combination with high‐dose chemotherapy for treatment‐naïve low‐ and intermediate‐risk acute myeloid leukemia (AML).AimsIn this retrospective real‐life multicenter study, we reported efficacy and safety of GO plus high‐dose chemotherapy in newly diagnosed AML patients.Methods and ResultsA total of 31 fit low‐ and intermediate‐risk AML patients treated with GO‐based regimens were retrospectively included in this real‐life multicenter study, and results were compared with a control cohort treated with 3 + 7 alone. Complete remission (CR) rate after induction was 77%, and most responders (45%) underwent two GO‐based consolidation, and minimal residual disease (MRD) negativity was observed in 17 cases (55%) after the end of consolidation. Low genetic risk was associated with increased CR rate compared with intermediate‐risk AML (88% vs. 33%; p < .001), as well as prolonged overall survival (OS; hazard ratio, 0.16; 95% confidential interval, 0.02–0.89; p < .001). GO addition resulted in a survival benefit for low‐risk AML (median OS not reached vs. 25 months; p = .19) while not for intermediate‐risk subjects (10 vs. 13 months; p = .92), compared with the control group. Moreover, GO‐treated patients experienced fever of unknown origin or sepsis in 42% or 36% of cases, respectively, with one death during induction due to septic shock, with similar rates compared with the control group (p = .3480 and p = .5297, respectively). No cases of veno‐occlusive disease after allogeneic transplantation were observed.ConclusionsOur real‐life multicenter study confirmed GO‐based treatment efficacy with high MRD negativity rates in fit newly diagnosed AML patients, especially in those with low genetic risk and core binding factor, while limited benefits were observed in intermediate‐risk AML. However, further validation on larger prospective cohorts is required.
Automatic Determination of the Non‐Covalent Stable Conformations of the NO2‐Pyrene Cluster in Full Dimensionality (81D) Using the vdW‐TSSCDS Approach
Authors: Panadés‐Barrueta Ramón L. , Duflot Denis , Soto Juan , Martínez‐Núñez Emilio , Peláez Daniel 
Published: April 2024

AbstractWe present the detailed topographical characterisation (stationary points and minimum energy paths connecting them) of the full dimensional (81D) intermolecular potential energy surface associated with the non‐covalent interactions between the NO2 radical and the pyrene (C16H10) molecule. The whole procedure is (quasi) fully automated. We have used our recent algorithm vdW‐TSSCDS as implemented on the freely‐available AutoMekin software package. To this end, a series of inexpensive classical trajectories using forces from a low‐level (semi‐empirical) theory are used to sample the configuration space of the system in the search for candidates to first order saddle points. These guess structures are determined by means of a graph‐theory based algorithm using the concept of adjacency matrix. Low‐level optimizations are followed by re‐optimizations at a final high‐level of theory (DFT and CCSD(T)‐F12 in our case.). The resulting set of stationary points and paths connecting them constitutes the so‐called reaction network. In the case of NO2‐pyrene, this network exhibits four major basins which can be characterized by their point‐group symmetry. A central one, of global C2 symmetry, comprises the global minimum (as well as all other permutationally related conformers) together with the corresponding C2v saddle points connecting them. This central basin is connected to three others of lower C1 symmetry. The latter can be distinguished by the projection of the position of the NO2 nitrogen atom on the pyrene plane in combination with the relative orientation of the oxygen pair pointing either inwards, outwards, upwards or downwards.
Sleep Quality and Suicidal Ideation in Adolescent Depression: A Chain Mediation Effect of Perceived Social Support and Resilience
Authors: Wu Yan , Guo Zixuan , Zhang Dawei , Wang Yongna , Wang Shufen 
Published: April 2024

ABSTRACTBackgroundThe prevalence of suicide is high among major depressive adolescents. Poor sleep quality has been documented as a significant risk factor for suicide, influencing perceived social support. Enhanced social support acts as a buffer against suicidal ideation and positively impacts resilience, reducing the prevalence of suicidal ideation. This reciprocal relationship between sleep quality, social support and resilience forms the basis for understanding the mechanisms contributing to suicidal ideation in major depressive adolescents.MethodsA total of 585 major depressive adolescents aged 11 to 24 years was conducted to explore these associations. Assessments included the Pittsburgh Sleep Quality Index, Multidimensional Scale of Perceived Social Support, Connor‐Davidson Resilience Scale and Beck Scale for Suicide Ideation. Pearson correlation and Model 6 in the SPSS program were employed for chain mediating tests.ResultsBetter sleep quality positively predicted decreased suicide ideation (β = 0.207, p < 0.01) and predicted lower perceived social support (β = −0.226, p < 0.01) and resilience (β = −0.355, p < 0.01). Perceived social support positively predicted increased resilience (β = 0.422, p < 0.01) and negatively predicted suicide ideation (β = −0.288, p < 0.01). Resilience negatively predicted suicide ideation (β = −0.187, p < 0.01). Sleep quality indirectly predicted suicide ideation through perceived social support and resilience, with a mediation value of 0.0678 (95% CI [0.0359, 0.1060]), constituting 10.65% of the total effect.ConclusionsThis study establishes that sleep quality indirectly predicts suicide ideation in major depressive adolescents, mediated independently by perceived social support and resilience.
CEO gender and climate change commitment: The mediating effect of environmental regulation perception
Authors: Harakati Racha , Ghazouani Ines , Hlioui Zaineb 
Published: April 2024

AbstractThis study delves into the influence of CEO gender on climate change commitment within SMEs in the Mediterranean region. Utilizing data from the sixth wave of the BEEPS survey (2018–2020), we explore the mediating role of environmental regulation perception in this context. Our findings align with social role theory, indicating that women demonstrate heightened ecological and communal behavior, driven by their perception of environmental regulations. We reveal a full mediation link within the EU Mediterranean region, where environmental regulation perception explains women's commitment to environmental causes. However, in the EU neighborhood, we identify a direct significant effect of CEO gender on SMEs' engagement with climate change, particularly in terms of controlling CO2 emissions. Our study sheds light on the limited presence of women in top management positions in the Mediterranean region. Additionally, we highlight the scarcity of environmental regulations for SMEs in the EU neighborhood, with the perception of these regulations as barriers hindering proactive climate change strategies. Therefore, governmental authorities need to develop more stringent environmental regulations while taking into account the financial capacities of SMEs. Providing ecological business education before implementing new regulations could also be beneficial. The study carries significant managerial and social implications, emphasizing the necessity of diverse leadership to promote sustainability and underscoring the importance of tailored regulatory initiatives for effective climate action.
Cross‐ownership and corporate ESG investment: Promotion or suppression?
Authors: Zhou Maochun , Niu Yuhua 
Published: April 2024

AbstractEnvironmental, social, and governance (ESG) investing is the new mainstream of sustainable development in the “dual‐carbon” era and serves as a crucial indicator for assessing enterprises' high‐quality development. Cross‐ownership, as an important participant in the capital market, significantly influences corporate business decisions. However, whether the impact of cross‐ownership on corporate ESG investment manifests as a synergistic governance effect or competitive collusion effect is a vital question. This study empirically investigates the impact of cross‐ownership on ESG investment, using listed companies in heavily polluting industries from the Shanghai and Shenzhen A‐shares between 2015 and 2022 as the research sample. The findings reveal that cross‐ownership positively influences corporate ESG investment by reducing information asymmetry, alleviating financing constraints, and enhancing corporate governance. This research not only expands the theoretical understanding of cross‐ownership and corporate ESG investment but also offers empirical guidance for improving corporate governance mechanisms and attaining sustainable development.
Enzyme_Metal‐Organic Framework Composites as Novel Approach for Microplastic Degradation
Authors: Rincon Irene , Hidalgo Tania , Armani Giacomo , Rojas Sara , Horcajada Patricia 
Published: April 2024

AbstractPlastic pollution is one of the main worldwide environmental concerns. Our lifestyle involves persistent plastic consumption, aggravating the low efficiency of wastewater treatment plants in its removal. Nano/microplastics are accumulated in living beings, pushing to identify new water remediation strategies to avoid their harmful effects. Enzymes (e. g., Candida rugosa‐CrL) are known natural plastic degraders as catalysts in depolymerization reactions. However, their practical use is limited by their stability, recyclability, and economical concerns. Here, enzyme immobilization in metal‐organic frameworks (CrL_MOFs) is originally presented as a new plastic degradation approach to achieve a boosted plastic decomposition in aqueous systems while allowing the catalyst cyclability. Bis‐(hydroxyethyl)terephthalate (BHET) was selected as model substrate for decontamination experiments for being the main polyethylene terephthalate (PET) degradation product. Once in contaminated water, CrL_MOFs can eliminate BHET (37 %, 24 h), following two complementary mechanisms: enzymatic degradation (CrL action) and byproducts adsorption (MOF effect). As a proof‐of‐concept, the capacity of a selected CrL_MOF composite to eliminate the BHET degradation products and its reusability are also investigated. The potential of these systems is envisioned in terms of improving enzyme cyclability, reducing costs along with feasible co‐adsorption of plastic byproducts and other harmful contaminants, to successfully remove them in a single step.
Comparing changes in eating disorder psychopathology and comorbid symptoms over treatment in anorexia nervosa and atypical anorexia nervosa in a partial hospitalization program
Authors: Perry Taylor R. , Lusich Rylee , Billman Miller Marley G. , Kaye Walter H. , Wierenga Christina E. , Brown Tiffany A. 
Published: April 2024

AbstractObjectiveThe objective of this study is to compare treatment trajectories in anorexia nervosa (AN) and atypical AN.MethodAdolescents and adults with AN (n = 319) or atypical AN (n = 67) in a partial hospitalization program (PHP) completed diagnostic interviews and self‐report questionnaires measuring eating disorder (ED), depression, and anxiety symptoms throughout treatment.ResultsPremorbid weight loss did not differ between diagnoses. Individuals with atypical AN had more comorbid diagnoses, but groups did not differ on specific diagnoses. ED psychopathology and comorbid symptoms of depression/anxiety did not differ at admission between groups nor did rate of change in ED psychopathology and comorbid symptoms of depression/anxiety from admission to 1‐month. From admission to discharge, individuals with atypical AN had a faster reduction in ED psychopathology and comorbid symptoms of depression and anxiety (ps < 0.05; rs = 0.01–0.32); however, there were no group differences in ED psychopathology or depression symptoms at discharge (ps>.50; ds = .01–.30). Individuals with atypical AN had lower anxiety at discharge compared to individuals with AN (p = 0.05; d = .4). Length of stay did not differ between groups (p = 0.11; d = .21).DiscussionGroups had similar ED treatment trajectories, suggesting more similarities than differences. PHP may also be effective for AAN.Public SignificanceThis study supports previous research that individuals with AN and atypical AN have more similarities than differences. Results from this study indicate that individuals with AN and atypical AN have similar treatment outcomes for both ED psychopathology and depressive symptoms; however, individuals with atypical AN have lower anxiety symptoms at discharge compared to individuals with AN. AN and atypical AN also have more symptom similarity at admission and throughout treatment, which challenges their current designation as distinct disorders.
N‐Heterocyclic Carbene Catalyzed Stetter–Aldol Domino Cyclization To Synthesize Tetrahydronaphthalene‐Fused Spirooxindoles
Authors: Xu Qiuling , Cui Qinghong , He Xiaoshan , Sun Ruifen , Wang Junliang 
Published: April 2024

AbstractA formal [4+2] annulation reaction of phthalaldehydes and 3‐ylideneoxindoles through a tandem process of a Stetter–aldol reaction was accomplished by the application N‐heterocyclic carbenes as effective catalysts. Under mild conditions, this unprecedented cascade reaction readily occurs in good yield, enabling straightforward access to functionalized tetrahydronaphthalene‐fused spirooxindoles. For the first time, the feasibility of an asymmetric Stetter–aldol reaction has also been briefly explored by employing chiral organic bases to promote the asymmetric transformation.
Performance evaluation of VCR system with pure and various blends of R134a, R1234yf, and R1234ze (E) refrigerants
Authors: Kuwar Yogendra Vasantrao 
Published: April 2024

AbstractThe current small passenger car vapor compression refrigeration systems use high global warming potential (GWP) refrigerants causing the greenhouse gas effect. In the present work, the low GWP of two pure refrigerants, R1234yf and R1234ze (E), and 16 blends of R134a, R1234yf, and R1234ze (E) are analyzed numerically. The experiments were conducted with R134a refrigerant to validate the numerical results. The experiments were conducted at the compressor speed of 600–1500 rpm and the condensing air at 30–40°C, relative humidity of 85%, and velocity of 1–3 m/s. The simulation and experimental results for R134a are deviated by a minimum of 10% and a maximum of 15%. It is found that the latent heat of vaporization of the two refrigerant mixtures with 80% R134a–20% R1234yf and the three refrigerant blends of 50% R134a–10% R1234yf–40% R1234ze (E) are the highest among 16 combinations. The other blends show a moderate difference of latent heat with R134a, but for maximum cooling capacity, the blends with 80% R134a–20% R1234yf and 50% R134a–10% R1234yf–40% R1234ze (E) are found to be more suitable for practical applications.