bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative evaluation of 90Y‐PET/CT and 90Y‐SPECT/CT‐based dosimetry following Yttrium‐90 radioembolization
Authors: Kappadath Srinivas Cheenu , Henry Eric Courtney , Lopez Benjamin P. , Mahvash Armeen 
Published: May 2024

AbstractBackgroundFollowing yttrium‐90 radioembolization (90Y‐RE), 90Y‐PET/CT and 90Y‐SPECT/CT imaging provide the means to calculate the voxelized absorbed dose distribution. Given the widespread use of the two imaging modalities and lack of well‐established standardized dosimetry protocols for 90Y‐RE, there is a clinical need to systematically investigate and evaluate differences in the performance of voxel‐based dosimetry between 90Y‐PET/CT and 90Y‐SPECT/CT.PurposeTo quantitatively analyze and compare 90Y‐PET/CT and 90Y‐SPECT/CT‐based dosimetry following 90Y‐RE.Methods90Y‐PET/CT and 90Y‐SPECT/CT imaging was acquired for 35 patients following 90Y‐RE with TheraSphere for the treatment of unresectable hepatocellular carcinoma. Dosimetry was performed using the local deposition method with known activity and the mean dose (Dmean) was calculated for perfused liver volumes (PV), tumors (T), and perfused normal livers (NL). Additionally, the absorbed dose to x% of the volume (Dx, x [5%, 10%, …, 90%, 95%]) and the volume receiving y Gy (Vy, y [10 Gy, 20 Gy, …, 190 Gy, 200 Gy]) were calculated for T and NL, respectively. Dose metrics were compared using linear regression, Bland‐Altman analysis, and statistical testing.ResultsBoth 90Y‐SPECT/CT and 90Y‐PET/CT‐based tumor Dmean were strongly correlated (R2 ≥ 0.90) with Dx, excluding metrics on the extrema. Intra‐modality comparisons of various Dx and Vy metrics yielded statistically significant differences (ANOVA, p < 0.001) for both90Y‐PET/CT and 90Y‐SPECT/CT. Based on statistical testing, only Dx metrics separated by greater than 20%–30% coverage, and only Vy metrics separated by greater than 40–70 Gy, reported significant differences. For PV, there was a strong correlation (R2 ≥ 0.99) between Dmean derived separately from 90Y‐PET/CT and 90Y‐SPECT/CT imaging. The strength of the correlation was slightly reduced for T and NL with R2 = 0.91 and R2 = 0.95, respectively. For PV, the mean bias ± standard error (SE) and 95% limits of agreement (LOA) between Dmean from the two modalities was effectively zero with ‐0.8 ± 0.4% (± 2.5%). For T and NL, the mean bias ± SE (± LOA) was ‐14.5 ± 3.7% (± 24%) and 9.4 ± 4.7% (± 27%), respectively.ConclusionThe strong correlation between Dmean and Dx suggests information from multiple dose metrics (e.g., D70 and Dmean) is largely redundant when establishing dose‐response relationships in 90Y‐RE. Dmean is highly correlated between 90Y‐PET/CT and 90Y‐SPECT/CT‐based dosimetry, for all liver VOIs. Relative to 90Y‐SPECT/CT, 90Y‐PET/CT, on average, yielded higher Dmean to tumors (14%) and lower Dmean to perfused normal livers (9%). Absorbed dose differences for perfused liver volumes between 90Y‐SPECT/CT and 90Y‐PET/CT were negligible.
Three‐dimensional EPI with shot‐selective CAIPIRIHANA for rapid high‐resolution quantitative susceptibility mapping at 3 T
Authors: Tourell Monique , Jin Jin , Bachrata Beata , Stewart Ashley , Ropele Stefan , Enzinger Christian , Bollmann Saskia , Bollmann Steffen , Robinson Simon Daniel , O'Brien Kieran , Barth Markus 
Published: May 2024

AbstractPurposeQSM provides insight into healthy brain aging and neuropathologies such as multiple sclerosis (MS), traumatic brain injuries, brain tumors, and neurodegenerative diseases. Phase data for QSM are usually acquired from 3D gradient‐echo (3D GRE) scans with long acquisition times that are detrimental to patient comfort and susceptible to patient motion. This is particularly true for scans requiring whole‐brain coverage and submillimeter resolutions. In this work, we use a multishot 3D echo plannar imaging (3D EPI) sequence with shot‐selective 2D CAIPIRIHANA to acquire high‐resolution, whole‐brain data for QSM with minimal distortion and blurring.MethodsTo test clinical viability, the 3D EPI sequence was used to image a cohort of MS patients at 1‐mm isotropic resolution at 3 T. Additionally, 3D EPI data of healthy subjects were acquired at 1‐mm, 0.78‐mm, and 0.65‐mm isotropic resolution with varying echo train lengths (ETLs) and compared with a reference 3D GRE acquisition.ResultsThe appearance of the susceptibility maps and the susceptibility values for segmented regions of interest were comparable between 3D EPI and 3D GRE acquisitions for both healthy and MS participants. Additionally, all lesions visible in the MS patients on the 3D GRE susceptibility maps were also visible on the 3D EPI susceptibility maps. The interplay among acquisition time, resolution, echo train length, and the effect of distortion on the calculated susceptibility maps was investigated.ConclusionWe demonstrate that the 3D EPI sequence is capable of rapidly acquiring submillimeter resolutions and providing high‐quality, clinically relevant susceptibility maps.
Sturgeons in materials from archaeological sites of Ukraine: A review
Authors: Volynskyi Tyt , Kovalchuk Oleksandr 
Published: May 2024

AbstractThe article presents a critical review of all published data on findings of the skeletal elements of sturgeons (Acipenseridae) during archaeological excavations conducted in the territory of Ukraine. Sturgeon remains are present in materials from 41 archaeological sites, the age of which covers the stage from the Neolithic (4 kyr bc) up to the Modern Period (17th century ad). Five species (Acipenser gueldenstaedtii, Acipenser nudiventris, Acipenser ruthenus, Acipenser stellatus, and Huso huso) are recognized. Of them, the Russian sturgeon, the sterlet, and the stellate sturgeon are the most abundant, while beluga is somewhat less numerous, and the fringebarbel sturgeon is represented by the smallest number of remains. The presence of the latter species (and the absence of the European sturgeon Acipenser sturio) in the historical past of Ukraine is discussed. We also highlight the importance of original and published data accessibility in archaeozoological research and discuss the issues of species identification, body length, and weight reconstruction of sturgeons based on skeletal elements.
Adolescent‐ and adult‐onset neuroblastic tumor: A retrospective multicenter observational study of patients diagnosed in France between 2000 and 2020
Authors: Magnier Orlane , Schiff Isabelle , Cristante Justine , Chabre Olivier , Veloso Melanie , Bosson Jean‐Luc , Defachelles Anne‐Sophie , Cordero Camille , Cao Christine Do , Thebaud Estelle , Drui Delphine , Berlanga Pablo , Dumont Benoit , Chastagner Philippe , Tandonnet Julie , Gambart Marion , Jannier Sarah , Pluchart Claire , Andry Leslie , Laithier Véronique , Klein Sébastien , Carausu Liana , Akbaraly Tasmine , Probert Jamie , Habert‐Dantigny Raphaelle , Plantaz Dominique 
Published: May 2024

AbstractBackgroundAdult‐ and adolescent‐onset neuroblastomas are rare, with no established therapy. In addition, rare pheochromocytomas may harbor neuroblastic components. This study was designed to collect epidemiological, diagnostic and therapeutic data in order to better define the characteristics of malignant peripheral neuroblastic tumors (MPNT) and composite pheochromocytomas (CP) with MPNT.ProcedureFifty‐nine adults and adolescents (aged over 15 years) diagnosed with a peripheral or composite neuroblastic tumor, who were treated in one of 17 institutions between 2000 and 2020, were retrospectively studied.ResultsEighteen patients with neuroblastoma (NB) or ganglioneuroblastoma (GNB) had locoregional disease, and 28 patients had metastatic stage 4 NB. Among the 13 patients with CP, 12 had locoregional disease. Fifty‐eight percent of the population were adolescents and young adults under 24 years of age. The probability of 5‐year event‐free survival (EFS) was 40% (confidence interval: 27%–53%).ConclusionsOutcomes were better for patients with localized tumor than for patients with metastases. For patients with localized tumor, in terms of survival, surgical treatment was the best therapeutic option. Multimodal treatment with chemotherapy, surgery, radiotherapy, and immunotherapy‐based maintenance allowed long‐term survival for some patients. Adolescent‐ and adult‐onset neuroblastoma appeared to have specific characteristics associated with poorer outcomes compared to pediatric neuroblastoma. Nevertheless, complete disease control improved survival. The presence of a neuroblastic component in pheochromocytoma should be considered when making therapeutic management decisions. The development of specific tools/resources (Tumor Referral Board, Registry, biology, and trials with new agents or strategies) may help to improve outcomes for patients.
Pore structure evolution and adsorption behaviors of porous poly (vinyl alcohol) hydrogel prepared using Na2SO4 and CaCO3 as porogens
Authors: Xiang Lubing , Yu Xi , Xiang Aimin , Lu Xiaoying , Zhang Meng , Zhou Hongfu 
Published: May 2024

AbstractIn this work, porous poly (vinyl alcohol) (PVA) hydrogels with different pore sizes were fabricated using inorganic non‐metallic porogens by an environmentally friendly method, providing a potential solution for the field of wastewater treatment. PVA hydrogels have gained much attention in the field of wastewater treatment due to their excellent adsorption performance and porous network structure. However, the employment of inorganic non‐metallic salts as porogens for PVA hydrogels has received limited attention so far. In this study, porous PVA hydrogels were prepared by freeze‐thawing and freeze‐drying with sodium sulfate (Na2SO4) and calcium carbonate (CaCO3) as porogens. PVA‐Na exhibited denser network structure with the concentration of Na2SO4 solution increased, and the tensile stress was enhanced by about 45 times. Meanwhile, the tensile stress of PVA‐Ca was improved significantly from 0.06 to 1.67 MPa, and the network structure became looser after adding CaCO3. Moreover, a comprehensive investigation was conducted on the adsorption performance of porous PVA hydrogel for Congo red (CR). Finally, five adsorption models were fitted to investigate the adsorption mechanism of porous PVA hydrogels, in which the maximum adsorption capacity of CR by PVA‐Na‐0.5 was predicted to be 215 mg/g by the Langmuir isothermal model fitting.Highlights
The structure of PVA hydrogels was adjusted by Na2SO4 and CaCO3, respectively.
The tensile stress of PVA‐Na with dense network structure increased 45 times.
Compared to PVA‐FD, swelling equilibrium time of PVA‐Na reduced from 24 to 6 h.
Equilibrium swelling rate of PVA‐Ca declined by half in comparison to PVA‐FD.
Langmuir isothermal model predicted qmax of 215 mg/g for CR by PVA‐Na‐0.5.
Olfactory preference of the litchi fruit borer for oviposition on two litchi varieties
Authors: Lin Xian‐yu , Zheng Yuan , Shen Ying , Li Dun‐Song 
Published: May 2024

AbstractBACKGROUNDThe litchi fruit borer Conopomorpha sinensis Bradley is a major destructive pest of litchi and longan plants in China, India and South East Asia. Given its strong olfactory‐based oviposition behaviour, interfering with the chemical communication between this insect pest and its host plant may serve as a potential control strategy. However, the chemical compounds associated with its egg‐laying behaviour remain poorly understood.RESULTSIn this study, we investigated the olfactory preference of female C. sinensis for oviposition on intact mature fruits of the Feizixiao (FZX) and Guiwei (GW) varieties. Results showed that female C. sinensis preferred to lay eggs on FZX compared with GW fruits, and this preference was olfactory‐induced. In addition, we identified differences in the chemical composition of the volatile blend and proportions between FZX and GW fruits, with terpenes being the main volatile components contributing to this divergence. Compounds that induced electrophysiological activity in female borers were subsequently screened from FZX. d‐Limonene exhibited the strongest oviposition attraction among four candidates. Furthermore, this compound served as a volatile olfactory cue for recognition and orientation in female C. sinensis.CONCLUSIONThe results of this study provide a deeper understanding of the olfactory preferences of female C. sinensis for oviposition on specific litchi varieties. © 2024 Society of Chemical Industry.
Left main coronary artery compression in precapillary pulmonary hypertension
Authors: Badea Ruxandra , Enache Roxana , Predescu Lucian M. , Platon Pavel , Catana Nicu , Deleanu Dan , Iosifescu Andrei George , Radu Noela , Radu Teodora , Olaru‐Lego Georgiana , Coman Ioan M. , Popescu Bogdan A. 
Published: May 2024

AbstractPulmonary hypertension (PH) is a progressive and invalidating condition despite available therapy. Addressing complications such as left main coronary artery compression (LMCo) due to the dilated pulmonary artery (PA) may improve symptoms and survival. Nevertheless, clear recommendations are lacking. The aim of this study is to analyze the prevalence, characteristics, predictive factors and impact of LMCo in a heterogenous precapillary PH population in a single referral center. Two hundred sixty‐five adults with various etiologies of precapillary PH at catheterization were reviewed. Coronary angiography (CA) was performed for LMCo suspicion. Revascularization was performed in selected cases. Outcomes were assessed at a mean follow‐up of 3.9 years. LMCo was suspected in 125 patients and confirmed in 39 (31.2%), of whom 21 (16.8%) had 50%–90% stenoses. Nine revascularizations were performed, with clinical improvement. The only periprocedural complication was a stent migration. LMCo was associated with PH etiology (p 0.003), occuring more frequently in congenital heart disease‐associated PH (61.5% of all LMCo cases, 66.6% of LMCo ≥ 50%). Predictors of LMCo ≥50% were PA ≥ 37.5 mm (Sn 81%, Sp 74%) and PA‐to‐aorta ≥1.24 (Sn 81%, Sp 69%), with increased discrimination when considering RV end‐diastolic area. LMCo ≥ 50% without revascularization presented clinical deterioration and worse survival (p 0.019). This analysis of a heterogeneous pre‐capillary PH population provides LMCo prevalence estimation, predictive factors (PA size, PA‐to‐aorta, RV end‐diastolic area and PH etiology) and long‐term impact. While LMCo impact on survival is inconclusive, untreated LMCo ≥ 50% has worse prognosis. LMCo revascularization may be performed safely and with good outcomes.
Financing sustainable development goals in Sub‐Saharan Africa: Does international capital flows matter?
Authors: Slimani Sana , Omri Anis , Abbassi Abdessalem 
Published: May 2024

AbstractThis study investigates the role of international capital flows in financing the Sustainable Development Goals (SDGs) in Sub‐Saharan Africa (SSA). Using data from 41 SSA countries from 2000 to 2018 and employing the System Generalized Method of Moments (System GMM), the research examines the impact of Foreign Direct Investment (FDI) and remittances on the SDGs across disaggregated levels (economic, social, and environmental sustainability) and the aggregated level (SDGI). The findings underscore the crucial significance of international capital flows as essential financing sources for SSA countries. FDI emerges as a contributor to economic and social sustainability at the disaggregated level, yet it exhibits negative effects on environmental sustainability. Conversely, remittances are shown to positively contribute to economic and social sustainability at the disaggregated level. However, the impact of international capital flows on the aggregate SDGI is found to be insignificantly positive. These results highlight the necessity for policymakers in SSA to devise strategies that maximize the benefits of FDI while addressing its adverse effects on environmental sustainability. Furthermore, they emphasize the importance of strengthening policies aimed at directing remittances towards sustainable investments, thereby advancing the achievement of the SDGs. Governments are urged to prioritize enhancing regulatory capacities in environmental matters through investments in modern technologies and appropriate standards, aiming to strike a balance between environmental protection and economic needs. Additionally, they should prioritize transparency, public participation, and robust enforcement mechanisms. Encouraging environmentally friendly foreign investments and promoting regional and international cooperation are also crucial steps towards effectively managing local environmental challenges.
Circular economy and waste production models for sustainable development goals 12 and 14: Evidence from cruise sustainability reporting
Authors: Di Vaio Assunta , Dell'Amura Giuseppe , Chhabra Meghna , Garofalo Antonio 
Published: May 2024

AbstractThe relationship between the practices and initiatives governing “waste production models” (sustainable development goal [SDG]12) and marine biodiversity goals (SDG14) is relatively unexplored. Aiming to bridge this gap by drawing on stakeholder and legitimacy theories, this study examines onboard cruise ships' circular economy (CE)‐based waste management practices and initiatives, correlating SGDs 12 and 14. Consequently, Carnival Corporation Plc's 2020–2022 sustainability reports are analyzed using content analysis by both Leximancer software (ver. 5.0) and manual methods. The results highlight the corporation's increasing commitment to green technologies for “waste production models” to achieve SDG14. However, its sustainability reports provide unclear evidence of the impact on marine biodiversity. Findings implies that practitioners should partner and invest in green technologies for “waste production models” to achieve SDG14. Besides being the first to explore the link between the two SDGs within the CE framework, this study advances insights into waste management within “waste production models,” enhancing the understanding of sustainable practices.
Eco‐Friendly Analytical Approaches for the Quantification of Molnupiravir and Favipiravir Using Capillary Zone Electrophoresis and Derivative Ratio Spectrophotometry
Authors: Nasr Mohamed S. , Talaat Wael , Kaddah Mohamed M. Y. , Omran G. , Morshedy S. 
Published: May 2024

AbstractDesigning new validated analytical procedures with a focus on many objectives, such as simplicity, environmental friendliness, analytical effectiveness, and sustainability, has grown to be a top priority in quality control departments. Applying green and white analytical chemistry concepts is no longer a luxury. In this report, two new approaches, Capillary Zone Electrophoresis (CZE) with Photo Diode Array (PDA) detection and derivative ratio spectrophotometric methods, are established and validated for the simultaneous analysis of molnupiravir (MLP) and favipiravir (FAV) in bulk, single dosage forms, and their expected combined dosage forms. For the two drugs, linearity ranges of 5–50 μg/mL and 1–30 μg/mL were achieved using the CZE and spectrophotometric methods, respectively. Both techniques have been validated and used for the estimation of the two medications in lab‐made capsules in accordance with the International Council for Harmonization's (ICH) recommendations. Seven assessment models were used to evaluate the greenness and sustainability of the introduced approaches compared to three previously published HPLC, chemometric, and HPTLC techniques. ChlorTox and BAGI tools are applied for the first time for the evaluation of an analytical procedure. Higher green and sustainable qualities were declared by suggested approaches than by earlier ones.
Vanadium Single Atoms Embedded in MoS2 Enabled Gut‐Brain Axis Neurotransmitter Detection at pM Levels
Authors: Sun Linxuan , Xu Hengyue , Bai Yichao , Chang Liang , Gao Jianxiang , Zhao Mingchuang , Huang Arthur Tran , Ma Lan , Lei Yu , Kang Feiyu , Terrones Mauricio 
Published: May 2024

AbstractThe detection of monoamine neurotransmitters is of paramount importance as the neurotransmitters are the chemical messengers regulating the gut‐brain axis (GBA). It requires real‐time, ultrasensitive, and selective sensing of the neurotransmitters in the gastric/intestinal fluid. However, multi‐components present in the gastric/intestinal fluid make sensing challenging to achieve in terms of ultra‐high sensitivity and selectivity. Herein, an approach is introduced to utilize vanadium single atom catalytic (SAC) centers in van der Waals MoS2 (V‐MoS2) to selectively detect real‐time serotonin (5‐HT) in artificial gastric/intestinal fluid. The synergetic effect of V‐SACs and the surface S‐bonds on the MoS2 surface, enables an extremely wide range of 5‐HT detection (from 1 pM to 100 µM), with optimum selectivity and interference resistance. By combining density functional theory calculations and scanning transmission electron microscopy, it is concluded that the V‐SACs embedded in the MoS2 network create active sites that greatly facilitate the charge exchange between the material and the 5‐HT molecules. This result allows the 5‐HT detection in GBA studies to be more reliable, and the material tunability provides a general platform to achieve real‐time and multi‐component detection of other monoamine neurotransmitters in GBA such as dopamine and norepinephrine.
Programmable Optoelectronic Synaptic Transistors Based on MoS2/Ta2NiS5 Heterojunction for Energy‐Efficient Neuromorphic Optical Operation
Authors: An Junru , Zhang Nan , Tan Fan , Zhao Xingyu , Chang Chunlu , Lanza Mario , Li Shaojuan 
Published: May 2024

AbstractThe optoelectronic synaptic transistors with various functions, broad spectral perception, and low power consumption are an urgent need for the development of advanced optical neural network systems. However, it remains a great challenge to realize the functional diversification of the systems on a single device. 2D van der Waals (vdW) materials can combine unique properties by stacking with each other to form heterojunctions, which may provide a strategy for solving this problem. Herein, an all‐2D vdW heterojunction‐based programmable optoelectronic synaptic transistor based on MoS2/Ta2NiS5 heterojunctions is demonstrated. The device implements reconfigurable, multilevel non‐volatile memory (NVM) states through sequential modulation of multiple optical and electrical stimuli to achieve broadband (532–808 nm), energy‐efficient (17.2 fJ), hetero‐synaptic functionality in a bionic manner. The intrinsic working mechanisms of the photogating effect caused by band alignment and the interfacial trapping defect modulation induced by gate voltage are revealed by Kelvin‐probe force microscopy (KPFM) measurements and carrier transport analysis. Overall, the (opto)electronic synaptic weight controllability for combined in‐sensor and in‐memory logic processors is realized by the heterojunction properties. The proposed findings facilitate the technical realization of generic all 2D hetero‐synapses for future artificial vision systems, opto‐logical systems, and Internet of Things (IoT) entities.