bluuebunny/crossref_metadata_2025_split huggingface dataset:
Caloric Restriction and Telomere Preservation in TERT Knockout Adipocyte Progenitors Does Not Rescue Mice From Metabolic Dysfunction due to a TERT Function in Adipocyte Mitochondria
Authors: Gao Zhanguo , Yu Yongmei , Eckel‐Mahan Kristin , Kolonin Mikhail G. 
Published: February 2025

ABSTRACTInactivation of telomerase (TERT) in adipocyte progenitor cells (APC) expedites telomere attrition, and the onset of diabetes in mice fed high‐fat diet (HFD), which promotes APC over‐proliferation and replicative senescence. Here, we show that time‐restricted feeding or caloric restriction in the postnatal development of mice subsequently subjected to HFD prevents telomere attrition but not glucose intolerance. This metabolic effect of dietary intervention was not observed for mice with TERT KO in endothelial or myeloid cells. To characterize the telomere‐independent effects of TERT in the APC lineage, we analyzed mice with TERT knockout in mature adipocytes (AD‐TERT‐KO), which do not proliferate and avoid telomere attrition. Analysis of adipocytes from AD‐TERT‐KO mice indicated reliance on glycolysis and decreased mitochondrial oxidative metabolism. We show that AD‐TERT‐KO mice have reduced cold tolerance and metabolism abnormality indicating a defect in adaptive thermogenesis, characteristic of aging. Conversely, ectopic TERT expression in brown adipocytes‐induced mitochondrial oxidation and thermogenic gene expression. We conclude that TERT plays an important non‐canonical function in the mitochondria of adipocytes.
Myofunctional therapy for obstructive sleep apnoea
Authors: Li W‐Y , Masse J‐F , Sériès F 
Published: February 2025

AbstractFailure of upper airway muscles to develop efficient dilating forces plays a key role in the occurrence of obstructive sleep apnoea in given patients. Thus, myofunctional therapy has been developed to improve the activity/efficacy of the upper airway (UA) dilator muscles, reduce its fatigability and improve mechanical performance. Various programmes, differing in the types of daytime exercises to be completed, as well as in their duration and intensity, have been evaluated. Meta‐analysis confirmed the efficacy of myofunctional therapy, with mean apnoea hypopnoea index (AHI) scores decreasing from 28.0 ± 16.2/h to 18.6 ± 13.1/h, and lowest oxygen saturation (LSAT) values improving from 83.2% ± 6.1% to 85.1% ± 7.0%. In children, MT and nasal washing may result in little to no difference in AHI. Integrating oropharyngeal exercises with the use of a smartphone application to complete and record exercise performances represents an innovative turn in the development of ambulatory MT programmes. Since adherence to therapy is a weakness in conventional OSA strategies such as CPAP, this approach to MT is promising, as evidenced by a 90% mean adherence to it after 3 months of using a smart application. There is further need to determine the most effective combination of exercise algorithms and identify the target population most likely to benefit from MT in outpatient training programmes.
Biodiversity–food trade‐offs when agricultural land is spared from production
Authors: Palmer Charles , Groom Ben , Sileci Lorenzo , Langton Steve 
Published: February 2025

AbstractBiodiversity conservation in agricultural landscapes, the world's predominant land use, could involve sparing, or setting aside, agricultural land from production, implying biodiversity–food trade‐offs. Employing bird species and agricultural data in two panel data sets, we evaluate the extent of set‐aside's trade‐offs in England between 1992 and 2007. Mixed biodiversity outcomes are reflected in a marginal effect, of a 100 ha increase in set‐aside, associated with a 1%–2% increase in species abundance and richness, no impact on Shannon‐Wiener diversity, and a 0.03 standard deviation fall in phylogenetic diversity. Lower phylogenetic diversity indicates that populations of less genetically distinct bird species appear when set‐aside increases. These effects are discontinuous for abundance and richness, and larger in the long run than in the short run for richness and phylogenetic diversity. Set‐aside led, on average, to a 7%–9% fall in cereal land. In turn, this led to an up to 2% decline in cereal output. A yield increase of 5%–10% is likely due to the setting aside of mostly marginal land. Biodiversity–food trade‐offs in agricultural landscapes could be minimized with a carefully targeted set‐aside policy, based on clearly defined biodiversity goals, and in settings where there is still scope for intensification.
Real‐World Efficacy and Safety of Abrocitinib in Chinese Atopic Dermatitis Patients: A Single‐Center Prospective Study
Authors: Li Zheng , Wang Yu , Wu Yuemeng , Yin Huibin , Wang Shangshang , Wu Hao , Qin Haihong , Wang Ce , Yao Xu , Li Wei , Gu Chaoying 
Published: February 2025

ABSTRACTBackgroundPhase 3 trials have demonstrated the efficacy and safety of abrocitinib for atopic dermatitis (AD), but real‐world evidence remains limited.MethodsThis study prospectively enrolled 117 moderate‐to‐severe AD patients at Huashan Hospital, Shanghai, China. Physician‐ and patient‐reported outcomes were evaluated at multiple time points. Blood eosinophil counts, serum IgE, and 24 cytokines/chemokines were measured.ResultsAbrocitinib treatment led to rapid and potent improvements in disease severity. At week 12, 74.3% and 50.5% of AD patients achieved at least 75% and 90% improvement in the eczema area and severity index (EASI), respectively. Compared to dupilumab, abrocitinib showed greater improvement in Itch‐NRS at week 2 and a higher proportion of EASI‐75 at week 4. Adverse events occurred in 42.7% of AD patients, with gastrointestinal symptoms being the most common (17.1%). No tuberculosis (TB) reactivation was observed in patients who screened positive for TB and received isoniazid prophylaxis during the study period. Lower body mass index (BMI < 24; adjusted OR: 4.01, 95% CI: 1.36–11.73) and no prior dupilumab use (adjusted OR: 5.81, 95% CI: 1.8–18.7) were identified as predictors of a good response. By week 4, blood eosinophil counts and serum IgE significantly decreased. Reductions in Th2‐, Th1‐, and Treg‐related cytokines/chemokines after 4 weeks of abrocitinib treatment, including IL‐5, CCL17, CCL18, TNF‐α, IL‐6, IL‐10, and CD25/IL‐2Rα, were more pronounced in good responders.ConclusionAbrocitinib demonstrated robust efficacy and a well‐tolerated safety profile in Chinese patients with moderate‐to‐severe AD in routine clinical practice, accompanied by normalization of elevated blood biomarkers.Trial RegistrationChiCRT Identifier: ChiCTR2200063195
Left Bundle Branch Pacing in a Pediatric Patient With Tricuspid Valve Replacement for a Complex Ebstein Anomaly
Authors: Tian Di , Jiang Longfu , Shen Jiabo 
Published: February 2025

ABSTRACTThis paper presents a unique case of successful implementation of left bundle branch pacing (LBBP) in a pediatric patient with third‐degree atrioventricular block following tricuspid valve replacement for a complex Ebstein anomaly. The procedure was performed under real‐time recording technique, and resulted in the resolution of the patient's symptoms. This case underscores the feasibility and potential benefits of LBBP in pediatric patients, particularly in those with complex congenital heart conditions and following valve replacement surgery. The successful implementation of LBBP in this case provides valuable insights and a reference for similar cases in the future.
Sadness is reduced by virtual hugging
Authors: Wang Xinyan , Liu Qiuhong , Li Xiang , Zheng Xixi , Hommel Bernhard , Ma Ke 
Published: February 2025

AbstractThis study investigated the possible effect of virtual interpersonal hugging on alleviating individual sad emotion. Using emotional self‐assessment and skin conductance responses, we recorded subjective and objective indicators before and after sad emotion induction, and after virtual interpersonal hugging, and assessed the role of (1) the characteristics of hugging, (2) participants' familiarity with the virtual hugging target, and (3) participants' face resemblance and perspective toward the virtual me‐avatar initiating the hugging. Results showed that (1) hugging a virtual target, but not the mere action of hugging, improves the regulation of sad emotion, (2) visual information dominates haptic information in the virtual hugging process, (3) facial familiarity of virtual targets of hugging and facial resemblance of the me‐avatar to participants do not affect the emotion regulation effect, and (4) first‐person perspective of the virtual me‐avatar influences both perceived ownership of hugging action and emotion regulation. Overall, virtual interpersonal hugging contributes to the regulation of sad emotion.
The Lipidomic Profile Discriminates Between MASLD and MetALD
Authors: Schneider Kai Markus , Cao Feng , Huang Helen Ye Rim , Chen Lanlan , Chen Yazhou , Gong Rongpeng , Raptis Anastasia , Creasy Kate Townsend , Clusmann Jan , van Haag Felix , Koop Paul‐Henry , Guillot Adrien , Luedde Tom , Loomba Rohit , Francque Sven , Schneider Carolin Victoria 
Published: February 2025

ABSTRACTBackgroundThe recent consensus statement redefined steatotic liver diseases. Metabolic dysfunction‐associated steatotic liver disease (MASLD) and metabolic dysfunction and alcohol‐related liver disease (MetALD) now represent distinct disease entities. However, biomarkers that differentiate MASLD and MetALD remain largely unknown.AimsTo identify lipidomic biomarkers with discriminatory potential for distinguishing MetALD from MASLD.MethodsUsing the UK Biobank dataset, 40,534 people with available MRI liver scans were analysed. A total of, 11,217 cases with a proton density fat fraction (PDFF) ≥ 5% were identified as having steatotic liver disease. Among these, lipidomic profiles were obtained for 5539 MASLD and 462 MetALD cases. A total of, 250 plasma lipidomic and metabolomic parameters were analysed. Mendelian randomisation (MR) analysis was used to confirm the association between alcohol consumption and the lipidomic biomarkers.ResultsWhen comparing the top 30 differentially expressed lipidomic biomarkers predicting MetALD compared to MASLD, the majority were related to HDL and were significantly overrepresented at both analysed time points. The top five metabolites were: acetoacetate, 3‐hydroxybutyrate, phospholipids in Large HDL, concentration of large HDL particles, free cholesterol in large HDL. The sensitivity analysis comparing alcohol‐related liver disease to MASLD revealed similar associations, suggesting that the HDL signature is stable over time. Additionally, MR analysis further confirmed that alcohol consumption was associated with increased levels of HDL‐related metabolites.ConclusionOur findings indicate that HDL‐centric lipidomic markers, particularly those within the larger and medium HDL subfraction, may differentiate MetALD from MASLD. Further longitudinal and experimental studies are warranted to validate these findings and assess their clinical implications.
The Cost of Untreated Perinatal Mood and Anxiety Disorders (PMADs) in Montana: An Economic Analysis of Perinatal Mental Health in a Rural State
Authors: Liddell Jessica L. , Monroe Alison , Carlson Tess A. , Mullan Katrina 
Published: February 2025

ABSTRACTBackgroundAlthough extremely common, and with a broad range of associated negative outcomes for both parents and infants, the full impact and cost of perinatal mood and anxiety disorders (PMADs) is under‐researched. Rural states, such as Montana, in particular experience gaps in access to mental healthcare and high rates of PMADs, emphasizing a need for an economic analysis of untreated PMADs. To address this gap, a cost analysis of the impact of untreated PMADs in Montana was conducted using 2021 birth data.MethodsA cost‐of‐illness analysis was conducted to estimate the incremental costs of untreated PMADs in Montana. Secondary data sources and peer‐reviewed literature were utilized to provide baseline estimates of the prevalence of maternal and birth outcomes in Montana and to estimate the impact of PMADs on these outcomes from the perinatal period through the first year postpartum.ResultsUsing 15% as the PMAD prevalence rate in Montana, the total estimated incremental cost of untreated perinatal mood and anxiety disorders for births in 2021 is about $21.7 million. This is about $12,897 per impacted mother–child pair.DiscussionThis study provides needed insight into the economic impact of untreated PMADs and highlights the broad range of negative impacts PMADs have on the well‐being of parents and infants. This study highlights the importance of providing effective treatment to people experiencing PMADs to improve the health of both parents and their infants and has important policy implications for increased funding and workforce development for the detection and treatment of PMADs.
Design and validation of a conceptual model for children's continuance intention to use video apps
Authors: Zhu Yumeng , Zhai Xuesong , Li Yan 
Published: February 2025

AbstractVideo apps are widely used by children worldwide. However, concerns have been raised about children's personal data disclosure and privacy risks during their consumption of video apps. This study designed and validated a conceptual model for children's continuance intention to use video apps based on privacy calculus theory and Teen Online Safety Strategies (TOSS) parental mediation framework. A cross‐sectional survey of 321 Chinese middle school‐aged children (aged 12–14) was conducted to validate the model. Our findings revealed that children's perceived risk had a minimal association with their perceived value. Children's perceived benefit was positively associated with their perceived value, which was positively associated with their continuance intention to use video apps. Trust also contributed to children's continuance intention to use video apps, slightly positively moderated by restrictive parental mediation. This study provided a better understanding of children's perception of privacy, trust and value in consuming video apps and identified the potential role of related parental mediation. To mitigate children's privacy risks and to enhance children's digital literacy as well as digital autonomy, we proposed some recommendations to video app designers, parents and educators. The study appeals to a more transparent and child‐centred approach in designing video apps, a mixed parental mediation for facilitating children's video app usage, and educators' empowering children's autonomy in online privacy protection by improving children's digital skills and competencies.
Serial sensitive molecular detection of JAK2 V617F is predictive of relapse after allogeneic stem cell transplantation in patients with myelofibrosis
Authors: Nedumannil Rithin , Karmi Tal , Blombery Piers , Szer Jeff , Ritchie David S. , Chee Lynette C. Y. 
Published: February 2025

SummaryRelapse after allogeneic stem cell transplantation (alloSCT) represents a frequent complication in patients with myelofibrosis (MF). This retrospective study analysed 38 patients with JAK2‐mutated MF who underwent alloSCT. Serial sensitive molecular assessments at regular intervals of JAK2 V617F revealed that a ≥2‐fold increase in JAK2 variant allele frequency (VAF) at days +100 and +180 post‐alloSCT was highly predictive of eventual morphological relapse. The integration of JAK2 VAF monitoring with chimerism analysis into post‐alloSCT care represents a novel strategy for early detection of MF relapse, which may enable timely interventions and improve outcomes in such high‐risk patients.
Unlocking the impact of US free trade agreements on industries with a synthetic control approach
Authors: Cho Sang‐Wook (Stanley) , Choi Hansoo 
Published: February 2025

AbstractThis study explores the industry‐level effects of the FTAs that the United States signed with Chile, Australia and the Dominican Republic between 2004 and 2007. Employing a synthetic control approach, we uncover heterogeneity in post‐FTA export growth across countries and industries. The study reveals that only a limited subset of industries in the US, which contributed to roughly one seventh of pre‐FTA exports, experienced post‐FTA export gains. No single industry consistently benefited from the FTAs with all three partners. This heterogeneity is present in countries where FTA‐induced aggregate export growth is absent, as well as in those where only a few industries drive the aggregate export growth. Export increases were also concentrated in a limited range of products. Notably, only exports to Chile led to increased export intensity and diversification at both the aggregate and industry levels. These findings, robust to various specifications and estimation methods, highlight the substantial variation in FTA effects across industries and partner countries.
The Clinical and Molecular Characterization of Distinct Subtypes in Adult T Cell Acute Lymphoblastic Leukemia
Authors: Yu Heye , Liu Wenbing , Zhang Junping , Xie Leling , Lai Anli , Tian Zheng , Tang Kejing , Xing Haiyan , Wang Ying , Wei Hui , Rao Qing , Gu Runxia , Wang Min , Wang Huijun , Wang Jianxiang , Qiu Shaowei 
Published: February 2025

ABSTRACTT‐cell acute lymphoblastic leukemia (T‐ALL) is a clonal proliferative malignant disease characterized by abnormal T‐cell development. The classification of T‐ALL primarily hinges on immunophenotype, encompassing early T‐cell precursor (ETP)‐ALL, near‐ETP‐ALL, and non‐ETP‐ALL. We summarized clinical information from 117 patients, with genetic data available for 77 patients and transcriptomic data available for 24 patients. An ETP‐like score model was established based on transcriptome, aiming to address the subjectivity in the current T‐ALL immunophenotype classification. The retrospective analysis indicated that ETP immunophenotype was not a prognostic factor for T‐ALL patients. Compared to non‐ETP‐ALL patients, ETP‐like patients including ETP‐ALL and near‐ETP‐ALL were more likely to carry MED12 gene mutations, which may predict a dismal outcome. Transcriptomic analysis suggested that T‐ALL patients with different immunophenotypes were in accordance with the T‐cell development trajectory, while ETP‐like patients exhibited characteristics of early T‐cell development. Finally, we established an ETP‐like score model and confirmed its efficiency across four independent cohorts, with sensitivity exceeding 80%. And T‐ALL patients with high ETP‐like score were associated with poor prognosis. In conclusion, our study elucidated the clinical and molecular features of distinct subtypes of T‐ALL patients, providing new valuable insights for T‐ALL classification.
GD2 is a Crucial Ganglioside in the Signal Modulation and Application as a Target of Cancer Therapeutics
Authors: Furukawa Koichi , Ohmi Yuhsuke , Hamamura Kazunori , Ohkawa Yuki , Hashimoto Noboru , Tajima Orie , Kaneko Kei , Furukawa Keiko 
Published: February 2025

ABSTRACTWhile various glycosphingolipids were identified as cancer‐associated carbohydrate antigens to be used as tumor markers, disialylated gangliosides such as GD3 and GD2 have particularly attracted attention from many researchers as promising cancer‐associated antigens. Simultaneously, their functions in cancer and normal tissues have also been reported. Although GD3 is expressed at the early neural developmental stage and in various cancers, it is also found in the activated status of some normal cells such as astrocytes and lymphocytes. On the other hand, GD2 is expressed in more restricted cells than GD3, enabling anti‐GD2 immune therapy to be more applicable for immunotherapy. Recently, the expression of GD2 has been reported in various epithelial cancers and neuroectoderm‐derived tumors. The involvement of GD2 in cancer stem cell propertiesand the roles of GD2 in the signal modulation to bring about cancer stemness are now some of the most fascinating research topics. Cancer immunotherapy targeting GD2 by anti‐GD2 antibody or anti‐GD2 CAR‐T is now widely being challenged with various modifications such as combination with cytokines, chemotherapy, or immune checkpoint blocking.
‘We're Not in a Place Where We Can Thrive Yet’: A Qualitative Exploration of Systems of Health Promotion in Primary Schools in the Aftermath of the COVID‐19 Pandemic
Authors: Bennett Annemarie E. 
Published: February 2025

ABSTRACTBackgroundHealth promotion in schools can be defined as any activity undertaken to improve the health of all school users. This qualitative study aimed to explore the systems of health promotion in primary schools in the aftermath of the COVID‐19 pandemic, from the perspectives of teachers and principals in the Republic of Ireland.MethodsParticipants were recruited using snowball and convenience sampling techniques via a larger quantitative study. Participants joined 45‐min online focus groups informed by a semi‐structured interview guide. A reflexive thematic approach was taken to analysis.ResultsThirty teachers participated, and most (n = 26) identified as female. Teaching experience across the sample ranged from 2 to 38 years. School sizes ranged from 20 to 850 students. All types of eligible publicly funded schools were represented. Three themes were generated: rebuilding the foundation, choosing within our limits and drawing the line.ConclusionFindings indicate that systems of health promotion in primary schools were severely challenged during the COVID‐19 pandemic and that recovery will be lengthy. School communities are well‐positioned to have a leading role in primary and secondary disease prevention, but investment is needed to establish resilient frameworks for health promotion as child health issues provoked by the pandemic are addressed over the coming years.
Personal Identity Development in Chinese Early Adolescents: Predictions From Parenting Style and Peer Relationships
Authors: Fan Weiqiao , Li Mengting 
Published: February 2025

ABSTRACTThis four‐wave longitudinal study among 698 Chinese early adolescents explored (1) how personal identity coherence and confusion develop; and (2) whether parenting style and peer relationships (i.e., close friend relationships and peer preference) were related to personal identity development. Participants (Mage = 11.39 yrs., SDage = 0.53; 53.7% girls) reported perceived parenting style, close friend relationships, and personal identity in Grade 6. Peer preference was assessed using peer nominations. Personal identity was remeasured in Grades 7, 8, and 9. The multiple‐indicator latent growth curve models revealed a decreased pattern in identity coherence and a curvilinear pattern in identity confusion. Higher authoritarian parenting and friend support were associated with sharper decreases in identity coherence. Implications for improving adolescent identity development were discussed.