bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the quality of antimicrobial prescribing in solid organ transplant recipients: a new frontier in antimicrobial stewardship
Authors: Kothari Sagar , Ahmad Syed Z. , Zhao Michelle T. , Teixeira-Barreira Abbigayle , So Miranda , Husain Shahid 
Published: May 2024

Abstract

Background:
Post-transplant infections remain a leading cause of morbidity and mortality in solid organ transplant recipients (SOTRs) and local standardized antimicrobial treatment guidelines may contribute to improved clinical outcomes. Our study assessed the rate of therapeutic compliance with local standard guidelines in the treatment of common infections in SOTR, and their associated outcomes.

Methods:
Consecutive adult SOTRs admitted to the transplant floor from January–September 2020 and were treated for an infectious syndrome were followed until discharge or for 30 days following the date of diagnosis, whichever was shorter. Data was extracted from electronic medical records. Guideline compliance was characterized as either appropriate, effective but unnecessary, undertreatment, or inappropriate.

Results:
Nine hundred and thirty-six SOTR were admitted to the transplant ward, of which 328 patients (35%) received treatment for infectious syndromes. Guidelines were applicable to 252 patients, constituting 275 syndromes: 86 pneumonias; 82 urinary tract infections; 40 intra-abdominal infections; 38 bloodstream infections; and 29 C. difficile infections. 200/246 (81%) of infectious syndromes received appropriate or effective but unnecessary empiric treatment. In addition, appropriate tailoring of antimicrobials resulted in a significant difference in 30-day all-cause mortality (adjusted OR of 0.07, 95% CI 0.01–0.38; P = .002). Lastly, we found that guideline-compliant empiric therapy was found to prevent the development of multi-drug resistance in a time-dependent analysis (adjusted HR of 0.21, 95% CI 0.08–0.52; P = .001).

Conclusion:
Our data show that adherence to locally developed guidelines was associated with reduced mortality and resistant-organism development in our cohort of SOTR.
Fear within the Frames: Horror Comics and Moral Danger
Authors: Woodcock Scott 
Published: May 2024

Abstract
Looking back, the moral panic that precipitated the decimation of horror comics in the 1950s seems quaint, yet concerns about the psychological impact of violent media on consumers have never disappeared. In this article, I outline a particular type of psychological impact we ought to take seriously when evaluating the moral status of entertainment. I then consider (a) ways in which comics seem immune from claims that they create this kind of impact for their readers, as well as (b) ways in which we might think that comics generate special instances of moral danger for readers.
Multi-model workload specifications and their application to cyber-physical systems
Authors: Burns Alan , Baruah Sanjoy 
Published: May 2024

Abstract
To address the question of how to deliver time-sensitive software for cyber-physical systems (CPS) requires a range of modelling and analysis techniques to be developed and integrated. A number of these required techniques are unique to time-sensitive software where timeliness is a correctness property rather than a performance attribute. This paper focuses on how to obtain worst-case estimates of the software’s execution time; in particular, it considers how workload models are derived from assumptions about the system’s run-time behaviour. The specific contribution of this paper is the exploration of the notion that a system can be subject to more than one workload model. Examples illustrate how such multi-models can lead to improved schedulability and hence more efficient CPS. An important property of the approach is that the derived analysis exhibits model-bounded behaviour. This ensures that the maximum load on the system is never higher than that implied by the individual models.
Observed meltwater-induced flexure and fracture at a doline on George VI Ice Shelf, Antarctica
Authors: Banwell Alison F. , Willis Ian C. , Stevens Laura A. , Dell Rebecca L. , MacAyeal Douglas R. 
Published: May 2024

Abstract
Global Navigation Satellite System (GNSS) observations and ground-based timelapse photography obtained over the record-high 2019/2020 melt season are combined to characterise the flexure and fracture behaviour of a previously formed doline on George VI Ice Shelf, Antarctica. The GNSS timeseries shows a downward vertical displacement of the doline centre with respect to the doline rim of ~60 cm in response to loading from a central meltwater lake. The GNSS data also show a tens-of-days episode of rapid-onset, exponentially decaying horizontal displacement, where the horizontal distance between the doline rim and its centre increases by ~70 cm. We interpret this event as the initiation and/or widening of a fracture, aided by stress perturbations associated with meltwater loading in the doline basin. Viscous flexure modelling indicates that the meltwater loading generates tensile surface stresses exceeding 75 kPa. This, together with our timelapse photos of circular fractures around the doline, suggests the first such documentation of meltwater-loading-induced ‘ring fracture’ formation on an ice shelf, equivalent to the fracture type proposed as part of the chain-reaction lake drainage process involved in the 2002 breakup of the Larsen B Ice Shelf.
Normalizing Relations from the Cold War to the Present: Continuing War, Pursuing Peace, and Building Empire
Authors: Demmer Amanda C. , Nichols Christopher McKnight 
Published: May 2024

Abstract“Normalization of relations” is a phrase of recent origin, widely used by scholars, politicians, and journalists. Defining normalization, however, is remarkably difficult. While we know a great deal about specific instances of normalization, we lack a sustained study of normalization itself, a gap this article begins to address. Using case studies of U.S. relations with China, Vietnam, and Cuba, this article examines the idea of normalization, its history, and its consequences. Focusing on pivotal moments in which “normalization” was at stake, we argue that in the American rendering, normalization was a process that unfolded in three phases. In turn, normalizing relations became a key nonmilitary means through which U.S. officials escalated and then deescalated the Cold War. Like other facets of U.S. diplomacy of the postwar period, normalization policies were premised on many of the assumptions and institutions of the “liberal international order” and have endured into the twenty-first century.
Mind the Gap: Why Wealthy Voters Support Brexit
Authors: Green Jane , Pahontu Raluca L. 
Published: May 2024

AbstractWealth provides self-insurance against financial risk, reducing risk aversion. We apply this insurance mechanism to electoral behaviour, arguing that a voter who desires a change to the status quo and who is wealthy is more likely to vote for change than a voter who lacks the same self-insurance. We apply this argument to the case of Brexit in the UK, which has been widely characterized as a vote by the ‘economically left-behind’. Our results show that individuals who lacked wealth are less likely to support leaving the EU, explaining why so many Brexit voters were wealthy, in terms of their property wealth. We corroborate our theory using two panel surveys, accounting for unobserved individual-level heterogeneity, and by using a survey experiment. The findings have implications for the potential broader role of wealth-as-insurance in electoral behaviour and for understanding the Brexit case.
Successful control of Echinococcosis in Argentina and Chile through a One Health approach, including vaccination of the sheep intermediate host
Authors: Poggio Thelma Veronica , Chacon Tomas , Larrieu Edmundo 
Published: May 2024

Abstract
Cystic echinococcosis control in South American countries requires a comprehensive integrative ‘One Health’ approach. While insular nations have seen successful in their elimination programmes, South American countries face persistent challenges in hostile environments, with Echinococcus granulosus s.l., posing a significant public health concern. Vaccination of intermediate hosts has demonstrated the efficacy of the EG95 vaccine in reducing transmission rates. For example, since 2009, Rio Negro Province in Argentina has added, with marked success, the EG95 vaccine to the control programme, supplementing dog deworming. The Aysen Region of Chile has also reported encouraging preliminary results in reducing cyst prevalence in vaccinated sheep after 3 years of vaccination. The challenges in aligning control strategies with socio-cultural factors, especially in indigenous communities, underlines the need for context-specific strategies. The Rio Negro programme demonstrated commendable compliance, underlining the importance of community engagement in achieving lasting success. The most promising strategies for effective echinococcosis control involved dog deworming and the routine vaccination of sheep and/or goats, underscoring the importance of sustained implementation until all grazing animals have been replaced. For lasting success, these interventions need to be combined with a robust surveillance system.
The liminal (vowel) space of womanhood: Fundamental frequency, formants, and the intersex body in Brazil
Authors: Dauphinais Civitello Ashlee 
Published: May 2024

Abstract
Despite the significance of intersex constituencies for explaining the social nature of sex and gender, intersex linguistic and social practices remain a yet unexplored frontier within sociolinguistics. This article examines fundamental frequency (F0) and vowel formant (F1–F3) production by participants with Turner Syndrome (TS), one of the most common intersex chromosomal conditions, in Rio de Janeiro, Brazil. This analysis demonstrates significant differences in fundamental frequency and F3 among different participant groups. I argue that height, growth hormone, and chromosomes are fundamental in constructing womanhood for TS women. Along with relevant ethnographic data, these results call for a re-examination of the body within linguistic and anthropological understandings of ‘womanhood’ and ‘femaleness’. This article highlights the ways these biological factors intersect with gendered perceptions of age and maturity, which can have real-world effects on linguistic practice and the social life of intersex individuals. (Brazilian Portuguese, fundamental frequency, gender, intersex, Turner Syndrome, vowel formants, critical intersex studies)*
A multi-stage localization framework for accurate and precise docking of autonomous mobile robots (AMRs)
Authors: Yilmaz Abdurrahman , Temeltas Hakan 
Published: May 2024

AbstractAutonomous navigation has been a long-standing research topic, and researchers have worked on many challenging problems in indoor and outdoor environments. One application area of navigation solutions is material handling in industrial environments. With Industry 4.0, the simple problem in traditional factories has evolved into the use of autonomous mobile robots within flexible production islands in a self-decision-making structure. Two main stages of such a navigation system are safe transportation of the vehicle from one point to another and reaching destinations at industrial standards. The main concern in the former is roughly determining the vehicle’s pose to follow the route, while the latter aims to reach the target with high accuracy and precision. Often, it may not be possible or require extra effort to satisfy requirements with a single localization method. Therefore, a multi-stage localization approach is proposed in this study. Particle filter-based large-scale localization approaches are utilized during the vehicle’s movement from one point to another, while scan-matching-based methods are used in the docking stage. The localization system enables the appropriate approach based on the vehicle’s status and task through a decision-making mechanism. The decision-making mechanism uses a similarity metric obtained through the correntropy criterion to decide when and how to switch from large-scale localization to precise localization. The feasibility and performance of the developed method are corroborated through field tests. These evaluations demonstrate that the proposed method accomplishes tasks with sub-centimeter and sub-degree accuracy and precision without affecting the operation of the navigation algorithms in real time.
Applications of artificial intelligence and cognitive science in design
Authors: Han Ji , Childs Peter R.N. , Luo Jianxi 
Published: May 2024

Abstract
Artificial intelligence and cognitive science are two core research areas in design. Artificial intelligence shows the capability of analysing massive amounts of data which supports making predictions, uncovering patterns and generating insights in varying design activities, while cognitive science provides the advantage of revealing the inherent mental processes and mechanisms of humans in design. Both artificial intelligence and cognitive science in design research are focused on delivering more innovative and efficient design outcomes and processes. Therefore, this thematic collection on “Applications of Artificial Intelligence and Cognitive Science in Design” brings together state-of-the-art research in artificial intelligence and cognitive science to showcase the emerging trend of applying artificial intelligence techniques and neurophysiological and biometric measures in design research. Three promising future research directions: 1) human-in-the-loop AI for design, 2) multimodal measures for design, and 3) AI for design cognitive data analysis and interpretation, are suggested by analysing the research papers collected. A framework for integration of artificial intelligence and cognitive science in design, incorporating the three research directions, is proposed to inspire and guide design researchers in exploring human-centred design methods, strategies, solutions, tools and systems.
Posthumous Harm and Changing Desires
Authors: Asker Andrea S. 
Published: May 2024

AbstractThe desire-satisfactionist defense of the existence of posthumous harm faces the problem of changing desires. The problem is that, in some cases where desires change before the time of their objects, the principle underlying the desire-satisfactionist defense of posthumous harm yields implausible results. In his prominent desire-satisfactionist defense of posthumous harm, David Boonin proposes a solution to this problem. First, I argue that there are two relevantly different versions of the problem of changing desires, and that Boonin's proposed solution addresses only one of them. Second, I argue that modifying the underlying principle is a better approach to overcoming the problem of changing desires since it addresses both versions of the problem. I defend this approach against objections by showing that the problems raised are problems for the principle as a general theory of harm, not for the principle as part of the desire-satisfactionist defense of posthumous harm.
Proteomic characterization of the different stages of seed germination in Cupressus gigantea
Authors: Li Jianxin , Zhang Subin , Lei Pei , Eh Tong-Ju , Zhang Yu , Jin Guangze , Dong Kun , Xu Qijiang , Luo Qiuxiang , Meng Fanjuan 
Published: May 2024

AbstractSeed germination is a pivotal period of plant growth and development. This process can be divided into four major stages, swelling absorption, seed coat dehiscence, radicle emergence and radicle elongation. Cupressus gigantea, a tree native to Tibet, China, is characterized by its resistance to stresses such as cold, and drought, and has a high economic and ecological value. Nevertheless, given its unique geographic location, its seeds are difficult to germinate. Therefore, it is crucial to explore the mechanisms involved in seed germination in this species to improve the germination efficiency of its seeds, thereby protecting this high-quality resource. Here, our findings indicate that seed germination was enhanced when exposed to a 6-h/8-h light/dark photoperiod, coupled with a temperature of 20°C. Furthermore, the application of exogenous GA3 (1 mg/ml, about 2.9 mM) stimulated the germination of C. gigantea seeds. Subsequently, proteomics was used to detect changes in protein expression during the four stages of seed germination. We identified 34 differentially expressed proteins (DEPs), including 13 at the radicle pre-emergence stage, and 17 at the radicle elongation stage. These DEPs were classified into eight functional groups, cytoskeletal proteins, energy metabolism, membrane transport, stress response, molecular chaperones, amino acid metabolism, antioxidant system and ABA signalling pathway. Most of them were found to be closely associated with amino acid metabolism. Combined, these findings indicate that, along with temperature and light, exogenous GA3 can increase the germination efficiency of C. gigantea seeds. Our study also offers insights into the changes in protein expression patterns in C. gigantea seeds during germination.
Maximum chordal subgraphs of random graphs
Authors: Krivelevich Michael , Zhukovskii Maksim 
Published: May 2024

AbstractWe find asymptotics of the maximum size of a chordal subgraph in a binomial random graph
$G(n,p)$
, for
$p=\mathrm{const}$
and
$p=n^{-\alpha +o(1)}$
.
The word frequency effect in first- and second-language reading by Chinese and Dutch bilinguals
Authors: Sui Longjiao , Woumans Evy , Duyck Wouter , Dirix Nicolas 
Published: May 2024

Abstract
High-frequency words are processed faster than low-frequency words, known as the word frequency effect (FE). Although the FE has been studied in various writing systems as well as in first- (L1) and second-language (L2) reading, existing theoretical hypotheses are mainly based on findings in alphabetic languages. To date, no study has investigated theoretical explanations of the FE such as the learning hypothesis, the lexical entrenchment hypothesis and the rank hypothesis apply to Chinese–English bilinguals. The present study, therefore, compared the FEs in Chinese– and Dutch–English bilinguals during natural paragraph reading in their L1 and L2, using eye-tracking measures. Chinese bilinguals exhibited a larger FE in L2 than in L1. They displayed smaller L1 FEs and much steeper L2 FE curves than Dutch bilinguals. These findings are not entirely consistent with the existing FE hypotheses, and the present study discusses theoretical accounts in light of the observed results.
Genetic and Environmental Influences on Perceived Stress in South Korean Twins
Authors: Jo Gwanwoo , Hur Yoon-Mi 
Published: May 2024

AbstractResearchers have proposed that culture significantly influences perceived stress (PS). To date, however, twin studies on PS have been conducted mostly in western, individualistic cultures, which demonstrate that PS due to controllable (personal) life events is more heritable than PS due to uncontrollable (network) life events. This study aimed to investigate genetic and environmental influences on PS in South Korean twins. South Korea practices a dominant collectivist culture. In total, 1372 twin individuals (mean age = 22.4 ± 2.5 years) completed an online survey on PS, which consisted of the scales, Friendship, Academic Stress, Future Career, Family Conflicts, and Family Financial Difficulties (FFD). Friendship, Academic Stress, and Future Career can be considered PS due to personal life events, and Family Conflict and FFD, PS due to network life events. The general sex-limitation model-fitting analysis revealed the absence of qualitative or quantitative sex differences in genetic and environmental influences. Specifically, additive genetic influences were predominant for Friendship (63%), Academic Stress (67%), and Future Career (57%) for both sexes, with the remaining variance attributable to nonshared environmental influences. In contrast, shared environmental influences were largest for Family Conflict (47% for both genders) and FFD (64% for males, 63% for females) with no significant genetic effects. Despite known cultural differences in the means and variances of PS, South Korean twins exhibited significant genetic effects in PS due to personal life events and large shared environmental effects in PS due to network life events, which is similar to western samples.
Meeting the need for effective and standardized neonatology training: a pan-European Master’s Curriculum
Authors: Santoro Deanna , Zibulsky Devin A. , Roehr Charles C. , Langhammer Florian , Vento Max , Szczapa Tomasz , Fauchère J.-C. , Dimitriou Gabriel , Rabe Heike , Mader Silke , Zimmermann Luc J. I. , Murray Deirdre M. , Smith Susan , Hall Mike , Künzel Manfred , Wellmann Sven 
Published: May 2024

Abstract
Neonatology is a pediatric sub-discipline focused on providing care for newborn infants, including healthy newborns, those born prematurely, and those who present with illnesses or malformations requiring medical care. The European Training Requirements (ETR) in Neonatology provide a framework for standardized quality and recognition of equality of training throughout Europe. The latest ETR version was approved by the Union of European Medical Specialists (UEMS) in April 2021. Here, we present the curriculum of the European School of Neonatology Master of Advanced Studies (ESN MAS), which is based on the ETR in Neonatology and aims to provide a model for effective and standardized training and education in neonatal medicine. We review the history and theory that form the foundation of contemporary medical education and training, provide a literature review on best practices for medical training, pediatric training, and neonatology training specifically, including educational frameworks and evidence-based systems of evaluation. The ESN MAS Curriculum is then evaluated in light of these best practices to define its role in meeting the need for a standardized empirically supported neonatology training curriculum for physicians, and in the future for nurses, to improve the quality of neonatal care for all infants.

Impact statement

A review of the neonatology training literature was conducted, which concluded that there is a need for standardized neonatology training across international contexts to keep pace with growth in the field and rapidly advancing technology. This article presents the European School of Neonatology Master of Advanced Studies in Neonatology, which is intended to provide a standardized training curriculum for pediatricians and nurses seeking sub-specialization in neonatology. The curriculum is evaluated in light of best practices in medical education, neonatology training, and adult learning theory.