bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mapping the interplay of atrial fibrillation, brain structure, and cognitive dysfunction
Authors: Petersen Marvin , Chevalier Céleste , Naegele Felix L. , Ingwersen Thies , Omidvarnia Amir , Hoffstaedter Felix , Patil Kaustubh , Eickhoff Simon B. , Schnabel Renate B. , Kirchhof Paulus , Schlemm Eckhard , Cheng Bastian , Thomalla Götz , Jensen Märit 
Published: June 2024

AbstractINTRODUCTIONAtrial fibrillation (AF) is associated with an elevated risk of cognitive impairment and dementia. Understanding the cognitive sequelae and brain structural changes associated with AF is vital for addressing ensuing health care needs.METHODS AND RESULTSWe examined 1335 stroke‐free individuals with AF and 2683 matched controls using neuropsychological assessments and multimodal neuroimaging. The analysis revealed that individuals with AF exhibited deficits in executive function, processing speed, and reasoning, accompanied by reduced cortical thickness, elevated extracellular free‐water content, and widespread white matter abnormalities, indicative of small vessel pathology. Notably, brain structural differences statistically mediated the relationship between AF and cognitive performance.DISCUSSIONIntegrating a comprehensive analysis approach with extensive clinical and magnetic resonance imaging data, our study highlights small vessel pathology as a possible unifying link among AF, cognitive decline, and abnormal brain structure. These insights can inform diagnostic approaches and motivate the ongoing implementation of effective therapeutic strategies.Highlights
We investigated neuropsychological and multimodal neuroimaging data of 1335 individuals with atrial fibrillation (AF) and 2683 matched controls.
Our analysis revealed AF‐associated deficits in cognitive domains of attention, executive function, processing speed, and reasoning.
Cognitive deficits in the AF group were accompanied by structural brain alterations including reduced cortical thickness and gray matter volume, alongside increased extracellular free‐water content as well as widespread differences of white matter integrity.
Structural brain changes statistically mediated the link between AF and cognitive performance, emphasizing the potential of structural imaging markers as a diagnostic tool in AF‐related cognitive decline.
Unimolecular Cucurbit[7]uril‐Based Indicator Displacement Assay with Dual Signal‐Readout for the Detection of Drugs
Authors: Picchetti Pierre , Balli Maria Vittoria , Baker Seth , Kumar Nilima Manoj , Gruhs Patrick , Prodi Luca , Biedermann Frank 
Published: June 2024

AbstractPoint‐of‐care diagnostics relies on optical and electrochemical sensors to develop devices that are both compact and cost‐effective. Therefore, the search for new design principles for chemosensors that enable multiple signal outputs is a particularly interesting concept. In this work, we present an unimolecular chemosensor based on cucurbit[7]uril that combines two signal readouts ‐ namely fluorescent and electrochemical signals ‐ in a single chemosensor design. This is achieved by utilizing the tunable fluorescence and the electrochemical properties of the reporter molecule, which depend on whether or not it is engulfed by the cucurbit[7]uril cavity in the absence or presence of the analyte. By setting up an assay using the dual readout chemosensor, illicit drug formulations containing pancuronium bromide or nicotine can be detected at low micromolar concentrations (0–100 μM). This assay is compatible with standard fluorescence plate readers and electrochemical devices, including commercially available screen‐printed electrodes. Overall, the chemosensor presented in this study represents a significant advance in the development of cucurbit[7]uril chemosensors, characterized by multimodal detection capabilities. It uniquely combines traditional optical and electrochemical detection methods in a single molecular design.
H−/H∞ filter‐based fault detection application to PEM fuel cell air‐feed system
Authors: Niane Moustapha , Zerrougui Mohamed , Outbib Rachid 
Published: June 2024

AbstractThis paper focuses on diagnosing faults and disturbances in the polymer electrolyte membrane (PEM) fuel cell air‐feed system. The main objective is to design a robust filter, specifically of the
type, to improve fault detection and attenuate perturbations. The
norm is employed to assess the fault sensitivity performance of the detection process, while the
norm guarantees the robustness of the proposed filter against disturbances. The approach utilized in this work is based on Lyapunov stability analysis, and the filter matrices are determined by solving a convex optimization problem formulated as linear matrix inequalities (LMIs). To illustrate the effectiveness of our results, a simulation is conducted under various disturbance and faulty scenarios. By integrating robust filtering techniques and addressing fault detection and disturbance attenuation, this study offers valuable insights for enhancing the performance and reliability of the PEM fuel cell air‐feed system.
LncRNA PVT1 facilitates the growth and metastasis of colorectal cancer by sponging with miR‐3619‐5p to regulate TRIM29 expression
Authors: Sun Zhenni , Li Xutong , Shi Yanyan , Yao Yasai 
Published: June 2024

AbstractBackgroundColorectal cancer (CRC) is the second most common cause of cancer‐related death worldwide. Long noncoding RNA (lncRNA) is involved in many malignant tumors. This study aimed to clarify the role of the lncRNA plasmacytoma variant translocation 1 (PVT1) in CRC growth and metastasis.MethodsDifferentially expressed lncRNAs in CRC were analyzed using the Cancer Genome Atlas. Gene expression profiling interactive analysis and a comprehensive resource for lncRNAs from cancer arrays databases were used to analyze lncRNA PVT1 expression and CRC prognosis, respectively. Cell counting kit‐8, wound healing, colony formation, Transwell, and immunofluorescence assays were used to evaluate CRC cell proliferation, migration, invasion, and epithelial‐mesenchymal transition (EMT), respectively. Tumor growth and metastasis models were used to explore the PVT1 effect on the growth and metastasis of CRC in vivo.ResultsPVT1 was highly expressed in CRC, associated with a poor prognosis of CRC, and showed good diagnostic value. Transfection of sh‐PVT1 or pcDNA3.1‐PVT1 reduced or increased the proliferation, wound healing rate, colony formation, invasion, and EMT of CRC cells. PVT1 and miR‐3619‐5p were co‐expressed in CRC cytoplasm, and PVT1 acted as a competitive endogenous RNA (ceRNA) by sponging miR‐3619‐5p to up‐regulate tripartite motif containing 29 (TRIM29) expression. MiR‐3619‐5p overexpression and TRIM29 knockdown reduced proliferation, wound healing rate, invasion, and EMT of CRC cells. However, simultaneous PVT1 and miR‐3619‐5p overexpression or knockdown of miR‐3619‐5p and TRIM29 knockdown rescued the malignant phenotype of CRC cells.ConclusionsWe first clarified the ceRNA mechanism of PVT1 in CRC, which induced growth and metastasis by sponging with miR‐3619‐5p to regulate TRIM29.
Ising‐Like Model Hasn't Yet Said Its Last Word: Exact and Mean‐Field Investigations of 2, 3 and 4‐Body Interactions in 1D Ising Chain of Binuclear Spin‐Crossover Solids
Authors: Boukheddaden Kamel , El Islam Belmouri Nour , di Scala Nicolas 
Published: June 2024

AbstractWe investigate the static properties of a new class of 1D Ising‐like Hamiltonian for binuclear spin‐crossover materials accounting for two‐, three‐, and four‐body short‐range interactions between binuclear units of spins
and
. The following 2‐, 3‐, and 4‐body
,
, and
terms are considered, in addition to intra‐binuclear interactions, such as effective ligand‐field energy and exchange‐like coupling. An exact treatment is carried out within the frame of the transfer matrix method, leading to a 4×4 matrix from which, we obtained the thermal evolution of the thermodynamic quantities. Several situations of model parameter values were tested, among which that of competing intra‐ and inter‐molecular interactions, leading to the occurrence of (i) one‐step spin transition, (ii) two‐, three‐, and four‐step transitions, obtained with a reasonable number of parameters. To reproduce first‐order phase transitions, we accounted for inter‐chains interactions, treated in the mean‐field approach. Hysteretic multi‐step transitions, recalling experimental observations, are then achieved. Overall, the present model not only suggests new landscapes of interaction configurations between SCO molecules but also opens new avenues to tackle the complex behaviors often observed in the properties of SCO materials.
Rearing and Experimental Uses of Daphnia: Controlling Animal Nutrition and Assessing Lifespan and Life‐History Traits
Authors: Frost Paul C. , Caudle Samatha L. , Han Sen , O'Brien Jocelyn M. J. , Tobin Stephanie W. 
Published: June 2024

AbstractCaloric restriction has been found to extend the lifespan of many organisms including mammals and other vertebrates. With lifespans exceeding months to years, age‐related experiments involving fish and mammals can be overtly costly, both in terms of time and funding. The freshwater crustacean, Daphnia, has a relatively short lifespan (∼50 to 100 days), which makes it a cost‐effective alternative animal model for longevity and aging studies. Besides age‐specific mortality, there are a suite of physiological responses connected to “healthspan” that can be tracked as these animals age including growth, reproduction, and metabolic rates. These responses can be complemented by assessment of molecular and cellular processes connected to aging and health. Lifespan and metabolism of this model organism is responsive to long studied modulators of aging, such as rearing temperature and nutritional manipulation, but also pharmacological agents that target aging, e.g., rapamycin, which adds to its usefulness as a model organism. Here we describe how to culture Daphnia for aging experiments including maintaining laboratory populations of Daphnia mothers, growing algal food, and manipulating nutrition of these animals. In addition, we provide methods for tracking common physiological and longevity responses of Daphnia. This protocol provides researchers planning to use this model organism with methods to establish and maintain Daphnia populations and to standardize their experimental approaches. © 2024 The Authors. Current Protocols published by Wiley Periodicals LLC.Basic Protocol 1: Culturing algae for Daphnia foodBasic Protocol 2: General methods for culturing DaphniaBasic Protocol 3: Standardizing and controlling nutrition for experimental DaphniaBasic Protocol 4: Monitoring Daphnia lifespanBasic Protocol 5: Evaluating Daphnia health: Heart rate and respiration, body mass and growth rates, and reproduction
The prospective trajectory of exosomes‐based cancer nanomedicine
Authors: Mirgh Divya , Sonar Swarup , Nyahatkar Sidhanti , Kalele Ketki , Adhikari Manab Deb 
Published: June 2024

AbstractExtracellular vesicles (EVs), including exosomes, ectosomes, and apoptotic bodies, play crucial roles in cellular communication and disease processes. Among these, exosomes are particularly significant for diagnosing, and cancer (which remains a leading cause of death worldwide). Exosomes offer cutting‐edge approaches in cancer nanomedicine, cancer biomarkers investigation (diagnosis and prognosis), and therapeutic. Exosomes are found in several body fluids (Blood, plasma, serum, urine, saliva, sweat, CSF, tear). It transforms the liquid biopsy method with more specificity. Exosome‐based sensor (electrochemical and aptamer‐based) developers were more effective and sensitive for cancer scanning. Therapeutic prospect stem cell‐derived exosomes, and plant‐derived exosomes become more promising. Due to its non‐toxicity (depending on the source), non‐immunogenic, biocompatibility and ability to cross biological membranes. Exosomes are an exciting nano‐drug transporter with specificity. Current time‐modified exosomes support to development of effective, efficient, and cost‐effective nanomedicine against cancer. Advanced nanotechnology and exosome combining (single exosome profiling, exosome barcoding)transform cancer theranostics approaches. Exosomes introduce a new horizon of cancer nanomedicine.
A global four‐dimensional gridded dataset of ocean dissolved oxygen concentration retrieval from Argo profiles
Authors: Xue Cunjin , Wang Zhenguo , Yue Linfeng , Niu Chaoran 
Published: June 2024

AbstractLack of a long‐term time series of dataset with a high spatiotemporal resolution at a global scale poses a great challenge to clarify the characteristics of DOC in space and depth, and its trend in time. Thus, there is an urgent need for the development of a global DOC gridded dataset in space, time and depth. The Biogeochemical Argo (BGC‐Argo) provides an important data source for obtaining global DOC, but is limited by irregular spatial sampling locations. Besides, BGC‐Argo has shorter time series coverage and fewer profiles compared to Core‐Argo. Thus, this manuscript aims at reconstructing the DOC profiles based on the Core‐Argo and BGC‐Argo profiles and then developing a spatial, temporal and depth‐specific gridded DOC dataset, named G4D‐DOC. Validation results demonstrate that G4D‐DOC has a good overall consistency with WOA18 and GLODAPv2 datasets, particularly at depths of 10 dbar and 1000 dbar, where it surpasses consistency at other standard depths. In addition, compared to WOA18, G4D‐DOC has achieved a breakthrough in a temporal resolution from a climatological monthly to monthly, and compared to GLODAPv2, G4D‐DOC has achieved a breakthrough in space from irregular discrete locations to regular grids. Further, G4D‐DOC can be widely used to conduct the characteristics of DOC in space and depth and its trends at global and regional scales. The metadata of G4D‐DOC is as follows: four dimensions mean two dimensions in space (longitude and latitude), one in time and one in depth; data format is standard Hierarchical Data Format Version 4 (HDF4) with a spatial resolution of 1 degree and temporal resolutions of annual, seasonal and monthly intervals at 26 standard layers above 2000 dbar in depth; the spatial coverage is global and the time period is from 2005 to 2022.
Nature of partial sigma bond
Authors: Nguyen Lam H. , Truong Thanh N. 
Published: June 2024

AbstractThis study investigates the formation of partial sigma (σ) covalent bonds in experimentally synthesizable biradicals formed from hydrogenated and fluorinated C8, C20, and C60 cage structures, by assessing their stability, geometry, and bonding character in singlet and triplet states using restricted B3LYP‐D3/6–31+G(d,p) theory, natural bond orbital (NBO) analysis, and complete active space self‐consistent field (CASSCF) method. The results show that these partial σCC bonds have Wiberg bond orders of 0.38 to 0.48 and bond lengths ranging from 2.62 Å to 5.93 Å. Cage size influences the characteristics of the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO), with electrons favoring more antibonding orbitals in smaller cages where electrons reside more on the exterior of the cage and favoring bonding orbitals in larger ones where electrons are more in the interior. Fluorination enhances electron density on bonding orbitals. The analysis further clarified that the differentiation between antibonding and bonding features of HOMOs and LUMOs extends beyond merely electron transfer from s‐ to p‐atomic orbitals, also noting possible interactions of the same symmetry repel. The study also introduces hyperconjugation from α‐position CH bonds as a factor in stabilizing partial σ‐bond formation. The results also caution against the use of broken symmetry methodology in unrestricted SCF wavefunctions for biradicals, such as those in this study as it may cause large spin contamination and thus errors in the calculated electronic properties results.
Posttraumatic stress symptoms and positive autobiographical memory characteristics in everyday life
Authors: Contractor Ateka A. , Slavish Danica C. , Wang Siyuan , Weiss Nicole H. 
Published: June 2024

AbstractIndividuals with posttraumatic stress symptoms (PTSS) report difficulties engaging with positive autobiographical memories. Extending this line of research, we examined daily‐level concurrent and lagged associations between PTSS severity and positive memory characteristics (vividness, coherence, accessibility, time perspective, sensory details, visual perspective, emotional intensity, sharing, distancing, and valence). The sample included 88 trauma survivors (Mage = 39.89 years, 59.1% female) who completed seven daily measures of PTSS and positive memory characteristics. Multilevel models examined concurrent and lagged associations between PTSS severity and positive memory characteristics. The results indicated that days with higher PTSS severity were associated with less accessibility, β = −.21, p < .001; less visual perspective, β = −0.13, p = .034; and lower positive valence of the memory, β = −.19, p = .003, as well as more emotional intensity associated with, β = .13, p = .041, and more distancing from, β = .21, p < .001, the memory. Supplemental lagged analyses indicated that higher previous‐day PTSS severity was associated with more next‐day distancing from, β = .15, p = .042, and sensory details of, β = .17, p = .016, the memory. Findings suggest that individuals with more severe PTSS have difficulties accessing positively valenced memories from a first‐person perspective, are more distant from the recalled positive memory, and report more emotional intensity when retrieving the memory. Thus, improving access to and reducing distance from positive autobiographical memories, as well as addressing emotional intensity surrounding the retrieval of these memories, may be potential clinical targets for PTSS interventions.
Natural disturbance allows multiple anuran taxa to persist in a dynamic wetland complex
Authors: Tawa Victoria , Tozer Douglas C. , Green David M. 
Published: June 2024

AbstractThe maintenance of biological diversity is frequently enhanced in a heterogenous landscape by some level of disturbance. Thus, when a landscape becomes stabilized and homogenized through the spread of an invasive plant species, there may be consequences for native biodiversity, particularly for those biotas that depend on the pre‐existing, natural disturbance regime of that landscape. At Long Point, Ontario, Canada, a sandspit in Lake Erie, the community of anuran amphibians experienced the co‐incidence of 2 major disturbance events, 1 anthropogenic and 1 natural: an intervention to remove the invasive form of the common reed (Phragmites australis australis) and a spate of extensive dune washouts caused by high water levels and storms. As a result of the unequal distribution of disturbance in the landscape, different areas were affected by only the dune washouts, only the common reed treatment, both disturbances, or neither disturbance. From May to August 2021, we explored how the disturbances affected the resident frog and toad species habitat associations in the 4 different disturbance conditions in the landscape. By means of minnow traps, acoustic surveys, and visual surveys, we determined that the dune washouts had a greater influence on resident anurans than the common reed treatment. Ranid frogs (Ranidae) tended to inhabit non‐washout sites, whereas Fowler's toads (Anaxyrus fowleri) congregated in the newly formed, sand flats and shallow, de‐vegetated pools resulting from the washouts. Neither ranid frogs nor Fowler's toads demonstrated avoidance of the sites affected by the herbicide treatment and mechanical rollover of the common reed. This evidence of species sorting, which enables multiple species to persist in a dynamic and heterogeneous landscape, suggests that wildlife management in aid of threatened species recovery may find success by encouraging natural disturbance regimes in dynamic landscapes. Future management endeavors should consider refraining from complete dune stabilization in these landscapes to allow the natural washouts to occur at a higher frequency, while ensuring the continued effectiveness of the invasive common reed eradication.
Structural Optimization of PA12/MVQ@POE‐g‐MAH Ternary Composite for Superior Toughness and Low‐Temperature Resistance
Authors: Jiang Zeshang , Li Zhongtian , Geng Jieting , Xia Lin 
Published: June 2024

AbstractTo enhance the low‐temperature toughness and resistance of the engineering plastic polyamide PA12, this study introduces novel PA12/MVQ@POE‐g‐MAH ternary composites using a two‐step process and dynamic curing. Analytical results indicate that incorporating MVQ@POE‐g‐MAH into the PA12 matrix markedly enhances its toughness and heat resistance. As the MVQ@POE‐g‐MAH content increases, the elongation at break of PA12 composites significantly expands from 52.83% to 204.69%, and the notch impact strength escalates from 8.69 to 74.34 kJ m−2. In addition, the brittleness temperature of PA12 decreases from −59.5 to −67.0 °C. Experimental findings confirm that POE‐g‐MAH is dispersed at the interface between MVQ and PA12, creating an encapsulated structure of MVQ@POE‐g‐MAH. This enhancement significantly broadens the potential applications of PA12 by improving its toughness, and resistance to both low and high temperatures, as well as impact endurance.
Chemoproteomics enables identification of coatomer subunit zeta‐1 targeted by a small molecule for enterovirus A71 inhibition
Authors: Li Xiaoyong , Zhang Jin , Xiao Yaxin , Song Hao , Li Yuexiang , Li Wei , Cao Ruiyuan , Li Song , Qin Yong , Wang Chu , Zhong Wu 
Published: June 2024

AbstractHuman enterovirus A71 (EV‐A71) is a significant etiological agent responsible for epidemics of hand, foot, and mouth disease (HFMD) in Asia‐Pacific regions. There are presently no licensed antivirals against EV‐A71, and the druggable target for EV‐A71 remains very limited. The phenotypic hit 10,10′‐bis(trifluoromethyl) marinopyrrole A derivative, herein termed MPA‐CF3, is a novel potent small‐molecule inhibitor against EV‐A71, but its pharmacological target(s) and antiviral mechanisms are not defined. Here, quantitative chemoproteomics deciphered the antiviral target of MAP‐CF3 as host factor coatomer subunit zeta‐1 (COPZ1). Mechanistically, MPA‐CF3 disrupts the interaction of COPZ1 with the EV‐A71 nonstructural protein 2C by destabilizing COPZ1 upon binding. The destruction of this interaction blocks the coatomer‐mediated transport of 2C to endoplasmic reticulum, and ultimately inhibits EV‐A71 replication. Taken together, our study disclosed that MPA‐CF3 can be a structurally novel host‐targeting anti‐EV‐A71 agent, providing a structural basis for developing the COPZ1‐targeting broad‐spectrum antivirals against enteroviruses. The mechanistic elucidation of MPA‐CF3 against EV‐A71 may offer an alternative COPZ1‐involved therapeutic pathway for enterovirus infection.