bluuebunny/crossref_metadata_2025_split huggingface dataset:
An empirical study of mechanisms to enhance entrepreneurs' capabilities through entrepreneurial learning in an emerging market
Authors: Jiao Hao , ogilvie dt , Cui Yu 
Published: June 2010

PurposeBased on behavioral learning theory, this paper argues that entrepreneurial learning plays an important role in enhancing entrepreneurs' capabilities. With increasing research attention given to entrepreneurs' capabilities, the need to explore the building mechanism has continued to escalate. The purpose of this paper is to explore the impact of changes in entrepreneurial learning approaches that influence the improvement of entrepreneurs' capabilities.Design/methodology/approachThe authors sent out 1,200 questionnaires, and 226 were returned, of which 167 were usable. The authors used the difference in difference method and the ordinal logistic regression model to analyze the data and test the hypotheses.FindingsIn this paper, the authors report findings using panel data from 167 entrepreneurs. The empirical results show that changes in entrepreneurial learning influence changes in entrepreneurs' capabilities.Practical implicationsCombining theory and evidence from this study, an intertemporal learning model that suggests entrepreneurs' capabilities rest on a self‐reinforcing learning cycle of experiential learning and social network learning from stakeholders is proposed. This is a sense‐making and seizing process affected by entrepreneurs' previous knowledge and their degree of involvement in the organization, which leads them to dedicate increasing resources to the exploration and exploitation of some opportunities, following a process of improving their capabilities.Originality/valueAn empirical verification of the links between learning and capabilities development in the context of China's emerging economy, which has not been studied in the current literature is conducted. This paper provides implications for entrepreneurs in finding the right way to build and enhance capabilities through deployment of learning.
Collective action in the implementation of a “greener” performance measurement system
Authors: Länsiluoto Aapo , Järvenpää Marko 
Published: June 2010

PurposeThe purpose of this paper is to investigate how different actors influenced the implementation of an environmental management system (EMS) and a performance measurement system (PMS) in a case company when the systems are eventually integrated. Another purpose is to illustrate how the frameworks of Gibson and Earley and Lovaglia et al. can be utilized to investigate the implementation of different management systems in practice.Design/methodology/approachThis paper is an interpretative case study, which utilizes qualitative methods such as semi‐structured interviews and internal documents.FindingsThe results indicate the importance of maintaining a separation between the power and status of an actor in EMS and PMS implementation processes, and the ways in which the power and status of actors in the EMS and PMS implementation differed. The status and role of an actor can change although the power may be static during the implementation of different management systems. Therefore, the paper confirms the classification of Lovaglia et al. and proposes that their classification should be added to the framework of Gibson and Earley.Originality/valueEarlier accounting studies using the institutional theory framework of Burns and Scapens did not specifically investigate the role of actors, or their power and status in implementing two different management systems. The collective action frameworks of Gibson and Earley and Lovaglia et al. have not been practically utilized before in EMS and PMS studies. Furthermore, EMS and PMS integration studies have usually been normative without empirical case data.
The influence of the types of NAS provisions and gifts hospitality on auditor independence
Authors: Law Philip 
Published: June 2010

PurposeAuditor independence is regarded as the cornerstone in the auditing profession. But there is lack of research to examine the influence of the types of non‐audit services provisions and gift hospitality on auditor independence. This paper aims to fill this gap.Design/methodology/approachThis Hong Kong study differs significantly from prior studies and is the first to examine the perceived independence by encompassing both qualitative and quantitative analysis. Binary logistic regression is used to capture data from Big 4 auditors and financial analysts' viewpoints.FindingsResults indicate that auditor independence decreases as the auditors provide accounting services, internal audit or corporate finance services to the firms. Corporate finance services have the greatest negative impact. However, it contributes new knowledge to the literature that the provisions of taxation services to clients are value‐added service and confirms the result in the US study. Receiving gift or hospitality from client has no influence on perceived independence and revokes an early study by Pany and Reckers. There is no expectation gap found between the groups, narrowing the expectation gap theory in the post‐Enron and revokes the US and the UK studies.Practical implicationsThe expectation gap theory seems to be narrowed in the post‐Enron environment. It is hoped that a longitudinal study could be conducted in future.Originality/valueThis paper adds new contributions to the auditing literature in the Asia Pacific Region and provides better understanding for devising auditing guidelines in Hong Kong and their international counterparts.
Who are your peers?
Authors: Hu Nan , Liu Ling , Shin Haeyoung , Zhang Jin 
Published: June 2010

PurposeThe purpose of this paper is to propose and evaluate a new matching sample comparison method, the industry size peer matching method.Design/methodology/approachBased on archival financial data from Compustat and econometric methods, the paper first validates that such a method will result in firms being divided into more homogenous groups, making peer‐performance comparison more meaningful. Then it compares this new peer matching method with previous methods through two resource‐based related studies in the IT valuation context.FindingsThe results show that the industry size matching method is a better method because: it is theoretically grounded, addressing industry, size, and random shock effects and, at the same time, avoids the selection bias caused by using a single firm as benchmark; and empirically such a technique results in more homogeneous groups and can explain more firm‐level returns than the industry‐only classification.Originality/valueMatched sample comparison group analysis is widely used in both academy and industry. The paper's theoretically grounds and empirically validated matching sample comparison method provides researchers and practitioners with a tool for their future research, performance evaluation, earning management detection, or compensation contract design, when selecting the right peers is called for.
Intranet use in Hong Kong public hospitals
Authors: Chun Cheong Fong Steve , Quaddus Mohammed 
Published: June 2010

PurposeThe purpose of this paper is to report the findings from a study of the relationships of organization support, user characteristics, task characteristics, and intranet characteristics for using intranet applications to support management accounting in public hospitals.Design/methodology/approachTo test the research hypotheses, data were collected from Hong Kong public hospitals using a questionnaire survey. The research attempts to identify how the interactions of these antecedents help to achieve intranet user information satisfaction (IUIS) and thus efficiency of management accounting in hospitals in terms of information quality of management accounting systems (MASIQ).FindingsThe results show that IUIS is positively associated with IQMAS in Hong Kong public hospitals. User characteristics such as information systems (IS) experience is positively associated with IUIS, and the extent of task characteristics is also positively associated with the IQMAS. The results have several implications for accounting IS management.Research limitations/implicationsThe paper provides support for some prior research findings and some findings are not consistent with expectations. The paper is based on questionnaire responses of 157 hospital executives. The findings are then generalized to the population studied – Hong Kong public hospitals. More research is needed for exploration and confirmation of these findings.Practical implicationsThe research offers insights into management accounting and control systems as they are implemented through the use of intranet in public hospitals. It suggests that top management support is of prior concern in improving managerial performance.Originality/valueThe paper bridges two disciplines of studies, management accounting and IS. The results provide some useful support of prior findings and some modifications and extensions that further understanding in this area.
ORIGINAL ARTICLE: Monoclonal autoantibodies to the TSH receptor, one with stimulating activity and one with blocking activity, obtained from the same blood sample
Authors: Evans Michele , Sanders Jane , Tagami Tetsuya , Sanders Paul , Young Stuart , Roberts Emma , Wilmot Jane , Hu Xiaoling , Kabelis Katarzyna , Clark Jill , Holl Sabrina , Richards Tonya , Collyer Alastair , Furmaniak Jadwiga , Smith Bernard Rees 
Published: June 2010

SummaryObjective  Patients who appear to have both stimulating and blocking TSHR autoantibodies in their sera have been described, but the two activities have not been separated and analysed. We now describe the isolation and detailed characterization of a blocking type TSHR monoclonal autoantibody and a stimulating type TSHR monoclonal autoantibody from a single sample of peripheral blood lymphocytes.Design, patients and measurements  Two heterohybridoma cell lines secreting TSHR autoantibodies were isolated using standard techniques from the lymphocytes of a patient with hypothyroidism and high levels of TSHR autoantibodies (160 units/l by inhibition of TSH binding). The ability of the two new monoclonal antibodies (MAbs; K1‐18 and K1‐70) to bind to the TSHR and compete with TSH or TSHR antibody binding was analysed. Furthermore, the effects of K1‐18 and K1‐70 on cyclic AMP production in Chinese hamster ovary cells (CHO) cells expressing the TSHR were investigated.Results  One MAb (K1‐18) was a strong stimulator of cyclic AMP production in TSHR‐transfected CHO cells and the other (K1‐70) blocked stimulation of the TSHR by TSH, K1‐18, other thyroid‐stimulating MAbs and patient serum stimulating type TSHR autoantibodies. Both K1‐18 (IgG1 kappa) and K1‐70 (IgG1 lambda) bound to the TSHR with high affinity (0·7 × 1010 l/mol and 4 × 1010 l/mol, respectively), and this binding was inhibited by unlabelled K1‐18 and K1‐70, other thyroid‐stimulating MAbs and patient serum TSHR autoantibodies with stimulating or blocking activities. V region gene analysis indicated that K1‐18 and K1‐70 heavy chains used the same V region germline gene but different D and J germline genes as well as having different light chains. Consequently, the two antibodies have evolved separately from different B cell clones.Conclusions  This study provides proof that a patient can produce a mixture of blocking and stimulating TSHR autoantibodies at the same time.
The influence of pelagic habitat selection and interspecific competition on productivity of juvenile walleye pollock (Theragra chalcogramma) and capelin (Mallotus villosus) in the Gulf of Alaska
Authors: LOGERWELL ELIZABETH A. , DUFFY‐ANDERSON JANET , WILSON MATTHEW , MCKELVEY DENISE 
Published: June 2010

AbstractHere we investigate processes affecting productivity of capelin and walleye pollock in the Gulf of Alaska. We examine pelagic habitat selection by comparing the distribution of juvenile fish and their prey with oceanographic properties and we evaluate the potential for interspecific competition by comparing diets and measures of foraging. The primary field study was conducted in Barnabus Trough, Kodiak Island, Alaska, during September 2005. The distribution of fish was assessed acoustically and trawls were used to collect individual fish for stomach content analyses. Physical and biological data were collected with conductivity–temperature–depth probes and zooplankton tows. Age‐0 pollock were distributed in cool waters offshore of a mid‐trough front, coincident with the distribution of euphausiids, their preferred prey. In contrast, capelin and their prey (copepods) were distributed throughout the trough. We observed that sympatric capelin (occurring with pollock) often had reduced foraging success compared to allopatric capelin (occurring alone). Results of a bioenergetic model also suggest that the exclusion of capelin from foraging on euphausiids can have negative consequences for capelin growth.
Consumer‐generated media and product labelling: designed in California, assembled in China
Authors: Saunders Stephen G. 
Published: June 2010

AbstractProduct country‐of‐origin labelling is an important extrinsic cue for consumers about a product's attributes. In a globalized world where products components and parts originate from multiple countries, companies have resorted to inventive country‐of‐origin labelling. The objective then of this paper is to better understand consumers' evaluation of products that have inventive country‐of‐origin labelling (i.e. Designed in California, Assembled in China). Exploratory qualitative data were collected from consumer‐generated media (36 weblogs) using Nielsen's Research BlogPulse tool. A grounded theory analysis revealed that four key themes emerged from the data that related to confusion about the labelling strategy, strong symbolic and emotional ties to country‐of‐origin, and the importance of country‐of‐origin as a quality signal.
Longevity is not influenced by prenatal programming of body size
Authors: Conover Cheryl A. , Bale Laurie K. , Grell Jacquelyn A. , Mader Jessica R. , Mason Megan A. 
Published: June 2010

SummaryInsulin‐like growth factor (IGF) signaling is essential for achieving optimal body size during fetal development, whereas, in the adult, IGFs are associated with aging and age‐related diseases. However, it is unclear as to what extent lifespan is influenced by events that occur during development. Here, we provide direct evidence that the exceptional longevity of mice with altered IGF signaling is not linked to prenatal programming of body size. Mice null for pregnancy‐associated plasma protein‐A (PAPP‐A), an IGF‐binding protein proteinase that increases local IGF bioavailability, are 60–70% the size of their wild‐type littermates at birth and have extended median and maximum lifespan of 30–40%. In this study, PAPP‐A−/− mice whose body size was normalized during fetal development through disruption of IgfII imprinting did not lose their longevity advantage. Adult‐specific moderation of IGF signaling through PAPP‐A inhibition may present a unique opportunity to improve lifespan without affecting important aspects of early life physiology.
Urinary estrogens, progesterone, and LH changes during normal menstrual cycles of a captive female pileated gibbon (Hylobates pileatus)
Authors: Aramaki Yusuke , Oae Hideaki , Mouri Yasushi , Takizawa Koji , Nakanishi Kazunori , Hyoudou Yoshio , Omasa Masao , Kusunoki Hiroshi 
Published: June 2010

AbstractUrinary steroid hormones and luteinizing hormone (LH) were monitored in a female pileated gibbon. The LH concentration almost peaked the day after estrogens peaks. The progesterone increased sharply after the LH peaks. Our results revealed for the first time the relationship between daily changes in urinary hormones throughout normal menstrual cycles in pileated gibbon.
α‐Glucosidase Inhibitory Activity of Bromophenol Purified from the Red Alga Polyopes lancifolia
Authors: Kim Keun Young , Nguyen The Han , Kurihara Hideyuki , Kim Sang Moo 
Published: June 2010

Abstract:  A bromophenol, bis(2,3‐dibromo‐4,5‐dihydroxybenzyl) ether, was purified from the red alga Polyopes lancifolia. Its IC50 values were 0.098 and 0.120 μM against Saccharomyces cerevisiae and Bacillus stearothermophilus α‐glucosidases, respectively, and 1.00 and 1.20 mM against rat‐intestinal sucrase and maltase. This bromophenol competitively inhibited S. cerevisiae α‐glucosidase with a KI value of 0.068 μM and was very stable at pH 2 for 60 min at 37 °C. Therefore, this P. lancifolia bromophenol may have potential as natural nutraceutical for the management of type 2 diabetes.Practical Application:  One therapeutic approach for preventing diabetes mellitus is to retard the absorption of glucose via inhibition of α‐glucosidase. In this study, one compound with strong α‐glucosidase‐inhibitory activity, bis(2,3‐dibromo‐4,5‐dihydroxybenzyl) ether, was purified and identified from the red alga P. lancifolia. Therefore, P. lancifolia bromophenol can potentially be developed as a novel natural nutraceutical for the management of type 2 diabetes.
Preoperative assessment of myometrial and cervical invasion in endometrial carcinoma: Comparison of multi‐section dynamic MR imaging using a three dimensional FLASH technique and T2‐weighted MR imaging
Authors: Emlik D , Kiresi D , Özdemir S , Çelik Ç , Karaköse S 
Published: June 2010

SummaryIntroduction: We aimed to show the diagnostic performance of magnetic resonance imaging by comparing T2‐weighted images and dynamic 3D MR images in the assessment of myometrial and cervical invasion by endometrial carcinoma.Methods: This prospective study included 53 women consecutively diagnosed with endometrial carcinoma. The subjects were evaluated by TSE T2‐weighted images and 3D FLASH‐VIBE dynamic MR images by two radiologists with a special training in gynecology. Sensitivity, specificity, negative and positive predictive values were calculated for each imaging modality with regard to assessment of myometrial and cervical invasion.Results: The diagnostic accuracy of TSE T2‐weighted and dynamic 3D FLASH‐VIBE MR imaging for the identification of any myometrial invasion were estimated as 64% and 84%, respectively. In the differentiation of deep myometrial invasion from the superficial invasion, the diagnostic accuracy of TSE T2‐weighted and dynamic 3D FLASH‐VIBE MR images were 75.5%, and 88.7%, respectively. Additionally, in the determining of deep myometrial invasion the sensitivity, the specifity, PPV, and NPV were 76%, 75%, 50%, and 90.9% on T2‐weighted images, respectively; 100%, 85%, 68.4%, and 100% on dynamic 3D MR images, respectively. The diagnostic accuracy of TSE T2‐weighted and dynamic 3D FLASH‐VIBE MR images for cervical invasion by endometrial carcinoma were 86%, and 92%, respectively.Conclusion: The multiplanar capabilities of MRI are invaluable to evaluate spreading and margins of an endometrial mass, and the 3D dynamic MR techniques offer the advantages of increased coverage and high spatial resolution. Three dimensional dynamic MR imaging may be recommended in the especially postmenouposal cases before performing potentially curative treatments.
Redesign, Reconstruction, and Directed Extension of the
Brevibacterium linens
C
40
Carotenoid Pathway in
Escherichia coli
Authors: Kim Se Hyeuk , Park Yun Hee , Schmidt-Dannert Claudia , Lee Pyung Cheon 
Published: June 2010

ABSTRACT

In this study, the carotenoid biosynthetic pathways of
Brevibacterium linens
DSMZ 20426 were reconstructed, redesigned, and extended with additional carotenoid-modifying enzymes of other sources in a heterologous host
Escherichia coli
. The modular lycopene pathway synthesized an unexpected carotenoid structure, 3,4-didehydrolycopene, as well as lycopene. Extension of the novel 3,4-didehydrolycopene pathway with the mutant
Pantoea
lycopene cyclase CrtY
2
and the
Rhodobacter
spheroidene monooxygenase CrtA generated monocyclic torulene and acyclic oxocarotenoids, respectively. The reconstructed β-carotene pathway synthesized an unexpected 7,8-dihydro-β-carotene in addition to β-carotene. Extension of the β-carotene pathway with the
B. linens
β-ring desaturase CrtU and
Pantoea
β-carotene hydroxylase CrtZ generated asymmetric carotenoid agelaxanthin A, which had one aromatic ring at the one end of carotene backbone and one hydroxyl group at the other end, as well as aromatic carotenoid isorenieratene and dihydroxy carotenoid zeaxanthin. These results demonstrate that reconstruction of the biosynthetic pathways and extension with promiscuous enzymes in a heterologous host holds promise as a rational strategy for generating structurally diverse compounds that are hardly accessible in nature.
Detection and Quantification of the Coral Pathogen
Vibrio coralliilyticus
by Real-Time PCR with TaqMan Fluorescent Probes
Authors: Pollock F. Joseph , Morris Pamela J. , Willis Bette L. , Bourne David G. 
Published: June 2010

ABSTRACT

A real-time quantitative PCR-based detection assay targeting the
dnaJ
gene (encoding heat shock protein 40) of the coral pathogen
Vibrio coralliilyticus
was developed. The assay is sensitive, detecting as little as 1 CFU per ml in seawater and 10
4
CFU per cm
2
of coral tissue. Moreover, inhibition by DNA and cells derived from bacteria other than
V. coralliilyticus
was minimal. This assay represents a novel approach to coral disease diagnosis that will advance the field of coral disease research.
AidH, an Alpha/Beta-Hydrolase Fold Family Member from an
Ochrobactrum
sp. Strain, Is a Novel
N
-Acylhomoserine Lactonase
Authors: Mei Gui-Ying , Yan Xiao-Xue , Turak Ali , Luo Zhao-Qing , Zhang Li-Qun 
Published: June 2010

ABSTRACT

N
-Acylhomoserine lactones (AHLs) are signaling molecules in many quorum-sensing (QS) systems that regulate interactions between various pathogenic bacteria and their hosts. Quorum quenching by the enzymatic inactivation of AHLs holds great promise in preventing and treating infections, and several such enzymes have been reported. In this study, we report the characterization of a novel AHL-degrading protein from the soil bacterium
Ochrobactrum
sp. strain T63. This protein, termed AidH, shares no similarity with any of the known AHL degradases but is highly homologous with a hydrolytic enzyme from
Ochrobactrum anthropi
ATCC 49188 that contains the alpha/beta-hydrolase fold. By liquid chromatography-mass spectrometry (MS) analysis, we demonstrate that AidH functions as an AHL-lactonase that hydrolyzes the ester bond of the homoserine lactone ring of AHLs. Mutational analyses indicate that the G-X-Nuc-X-G motif or the histidine residue conserved among alpha/beta-hydrolases is critical for the activity of AidH. Furthermore, the AHL-inactivating activity of AidH requires Mn
2+
but not several other tested divalent cations. We also showed that AidH significantly reduces biofilm formation by
Pseudomonas fluorescens
2P24 and the pathogenicity of
Pectobacterium carotovorum
, indicating that this enzyme is able to effectively quench QS-dependent functions in these bacteria by degrading AHLs.