bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prostate Cancer Diagnosis Rates among Insured Men with and without HIV in South Africa: A Cohort Study
Authors: Ruffieux Yann , Fernández Villalobos Nathalie V. , Didden Christiane , Haas Andreas D. , Chinogurei Chido , Cornell Morna , Egger Matthias , Maartens Gary , Folb Naomi , Rohner Eliane 
Published: May 2024

Abstract

Background:
Several studies have found lower prostate cancer diagnosis rates among men with human immunodeficiency virus (HIV; MWH) than men without HIV but reasons for this finding remain unclear.

Methods:
We used claims data from a South African private medical insurance scheme (July 2017– July 2020) to assess prostate cancer diagnosis rates among men aged ≥ 18 years with and without HIV. Using flexible parametric survival models, we estimated hazard ratios (HR) for the association between HIV and incident prostate cancer diagnoses. We accounted for potential confounding by age, population group, and sexually transmitted infections (confounder-adjusted model) and additionally for potential mediation by prostatitis diagnoses, prostate-specific antigen testing, and prostate biopsies (fully adjusted model).

Results:
We included 288,194 men, of whom 20,074 (7%) were living with HIV. Prostate cancer was diagnosed in 1,614 men without HIV (median age at diagnosis: 67 years) and in 82 MWH (median age at diagnosis: 60 years). In the unadjusted analysis, prostate cancer diagnosis rates were 35% lower among MWH than men without HIV [HR, 0.65; 95% confidence interval (CI), 0.52–0.82]. However, this association was no longer evident in the confounder-adjusted model (HR, 1.03; 95% CI, 0.82–1.30) or in the fully adjusted model (HR, 1.14; 95% CI, 0.91–1.44).

Conclusions:
When accounting for potential confounders and mediators, our analysis found no evidence of lower prostate cancer diagnosis rates among MWH than men without HIV in South Africa.

Impact:
Our results do not support the hypothesis that HIV decreases the risk of prostate cancer.
Plasma Metabolic Profiles-Based Prediction of Induction Chemotherapy Efficacy in Nasopharyngeal Carcinoma: Results of a Bidirectional Clinical Trial
Authors: Tang Tingxi , Zhou Zhenhua , Chen Min , Li Nan , Sun Jianda , Chen Zekai , Xiao Ting , Wang Xiaoqing , Zhang Longshan , Wang Yingqiao , Zhang Hanbin , Zheng Xiuting , Chen Bei , Ye Feng , Guan Jian 
Published: May 2024

Abstract

Purpose:
The efficacy of induction chemotherapy (IC) as a primary treatment for advanced nasopharyngeal carcinoma (NPC) remains a topic of debate, with a lack of dependable biomarkers for predicting its efficacy. This study seeks to establish a predictive classifier using plasma metabolomics profiles.

Patients and Methods:
A total of 166 NPC patients enrolled in the clinical trial NCT05682703 who were undergoing IC were included in the study. Plasma lipoprotein profiles were obtained using 1H-nuclear magnetic resonance before and after IC treatment. An artificial intelligence-assisted radiomics method was developed to effectively evaluate its efficacy. Metabolic biomarkers were identified through a machine learning approach based on a discovery cohort and subsequently validated in a validation cohort that mimicked the most unfavorable real-world scenario.

Results:
Our research findings indicate that the effectiveness of IC varies among individual patients, with a correlation observed between efficacy and changes in metabolite profiles. Using machine learning techniques, it was determined that the extreme gradient boosting model exhibited notable efficacy, attaining an area under the curve (AUC) value of 0.792 (95% CI, 0.668–0.913). In the validation cohort, the model exhibited strong stability and generalizability, with an AUC of 0.786 (95% CI, 0.533–0.922).

Conclusions:
In this study, we found that dysregulation of plasma lipoprotein may result in resistance to IC in NPC patients. The prediction model constructed based on the plasma metabolites’ profile has good predictive capabilities and potential for real-world generalization. This discovery has implications for the development of treatment strategies and may offer insight into potential targets for enhancing the effectiveness of IC.
Writing Sacred Histories in Late Ottoman Egypt: Zaynab Fawwāz and Qadriyya Kāmil’s Descriptions of Early Islam
Authors: Liepsner Nura Sophia 
Published: May 2024

Abstract
This article studies contrasting notions of historiography in Zaynab Fawwāz and Qadriyya Kāmil’s biographical dictionaries. It begins by offering an overview on these authors’ vitas and delves into the historiographical practices that concerned Ottoman intellectuals in the late nineteenth century. It analyses Fawwāz’s dictionary, al-Durr al-manthūr fī ṭabaqāt rabbāt al-khudūr (1894), which reveals a feminist understanding of Islam as situated within an Arab and pan-Ottoman environment as well as the large arch of Abrahamic monotheism. By highlighting specific figures over others, Fawwāz produces a historical narrative that transcends religious and sectarian divides. The article then introduces Kāmil’s Shahīrāt al-nisāʾ fī l-ʿālam al-islāmī (1924) which depicts a conceptually narrower Islam, shaped by the geo-political circumstances of the early twentieth century. The biographies of the Muslim foremothers Kāmil presents offer normative templates of female piety but are not completely subsumed by the category of gender either. Throughout, the article points to how both authors engage the rules of the biographical genre, arguing that the ways they adhere to or break with its tradition indicate a desire to create new forms of moral and communal belonging.
Variation in dietary composition of the Banna fanged frog (Limnonectes bannaensis Ye, Fei, Xie & Jiang, 2007) from Vietnam
Authors: Pham Anh Van , Sung Nenh Ba , Nguyen Truong Quang , Le Minh Duc , Tran Thuy Van , Ziegler Thomas 
Published: May 2024

Abstract
The Banna fanged frog (Limnonectes bannaensis) is known from China, Laos, and Vietnam; however knowledge about the natural history and dietary requirements of this species is virtually lacking. In this study, we provide data on the variation in dietary composition of L. bannaensis based on stomach-flushing of 117 individuals (41 males and 76 females) captured and subsequently released during our recent field work in Son La Province, northwestern Vietnam. A total of 19 prey categories with 513 items, comprising 502 items of invertebrates, seven items of vertebrates, and four unidentified items were found in the stomachs of L. bannaensis. The most important groups among the prey of L. bannaensis were Coleoptera (38.04%), followed by Hymenoptera (9.31%), Araneae (7.93%), Polydesmida (7.07%), Orthoptera (6.37%), Hemiptera (5.23%), and Lepidoptera (5.01%). Adult males (16 prey categories) consumed preys with slightly lower diversity than adult females (17 prey categories). There was 88.25% overlap in the diet between males and females and in both sexes the trophic spectrum was similar, predominantly consisting of Coleoptera, Polydesmida, Araneae, Hymenoptera, Orthoptera, Lepidoptera, and Hemiptera.
Consequentialism, Collective Action, and Blame
Authors: Schmidt Andreas T. 
Published: May 2024

Abstract
Several important questions in applied ethics – like whether to switch to a plant-based diet, reduce greenhouse gas emissions, or vote in elections – seem to share the following structure: if enough people ‘cooperate’ and become vegan for example, we bring about a better outcome; but what you do as an individual seems to make no difference whatsoever. Such collective action problems are often thought to pose a serious challenge to consequentialism. In response, I defend the Reactive Attitude Approach: rather than focus only on the deontic status of (non-)cooperative acts – as existing consequentialist responses mostly do – consequentialists should also focus on when to praise or blame individuals. For example, even if your veganism does not change the overall outcome, consequentialists might still recommend praising you for your cooperative behavior. I make a consequentialist case for including praise and blame in our ethical practices around collective action and argue that doing so helps us capture important intuitions. I develop and defend these arguments by drawing on recent instrumentalist theories of blame and responsibility.
Ribosome-binding protein-1 (RRBP1) expression in prostate carcinomas and its relationship with clinicopathological prognostic factors
Authors: Kuzuluk Didar Gursoy , Secinti Ilke Evrim , Erturk Tugce , Hakverdi Sibel , Gorur Sadik , Ozatlan Dilan 
Published: May 2024

Introduction Studies in recent years have shown that ribosome-binding protein-1 (RRBP1) is expressed at high rates in many cancers and that it may be a potential prognostic biomarker. The objective of the present study is to determine the RRBP1 expression level in prostatic carcinoma and neighboring non-neoplastic prostate tissue, the relationship between its expression level with prognostic factors, and the role of RRBP1 in the development of prostate cancer. Materials and methods The study included 45 patients who were diagnosed with prostatic carcinoma and underwent radical prostatectomy in our center between the years 2010 and 2021. Pathology reports were reviewed. Mann–Whitney U test was used for the comparison of RRBP1 and GADPH values of the cases (control and tumoral tissue) between the primary tumor stage (pT) and Gleason score (GS) groups. Hierarchical regression analysis was used to explain the effective variables in explaining the RRBP1 value of the research cases Results According to the Mann–Whitney U test, mean and median RRBP1-T values of the cases with GS ≥ 8 were detected to be statistically significantly higher than the mean and median RRBP1-T values of the cases with GS < 8. Conclusion We found out that RRBP1 was expressed at higher rates in patients with high GS and advanced-stage patients. This result indicated that RRBP1 expression may be important in predicting the prognosis of prostate carcinoma.
Mechanical investigation for enhancing jute fibre vinyl ester composite performance through garnet waste utilization
Authors: Rajendran Sundarakannan , Palani Geetha , Yang Yo-Lun , Veerasimman Arumugaprabu , Shanmugam Vigneshwaran , Marimuthu Uthayakumar , Kannan Karthik 
Published: May 2024

This study explores the potential utilization of garnet waste, a byproduct of the Abrasive Water Jet Machining process, as a promising filler material in composite manufacturing. The disposal of garnet waste presents significant environmental and economic challenges, underscoring the need for sustainable waste management strategies. To tackle these challenges, this research investigates the incorporation of garnet waste into composites to create value-added materials. Consequently, the study focused on developing garnet-filled jute fibre-reinforced vinyl ester composites using the hand layup method. Various mechanical properties including flexural strength, tensile strength, hardness, and impact strength were assessed. The findings demonstrate that the inclusion of garnet filler enhances the mechanical strength of the composites. Particularly, composites containing 10 wt% garnet exhibit notable improvements in tensile, flexural, impact, and hardness strengths, with increases of 40%, 124%, 26%, and 15%, respectively. This research has the potential to advance the development of advanced materials across diverse industries, marking a significant stride towards sustainable and value-driven composite manufacturing practices.
Treatment Outcomes of Lip Taping in Patients with Non-syndromic Cleft Lip and/or Palate: A Systematic Review and Meta-analysis
Authors: R Vignesh , Singhal Ruchi , Namdev Ritu , Kumar Adarsh , Dayma Charu , Rani Asha 
Published: May 2024

Objective To conduct a systematic review of the data in peer-reviewed medical literature and evaluate the effectiveness of lip taping as a pre-surgical naso-alveolar molding (NAM) technique in infants with cleft lip and/or palate. Design An electronic search of various databases for relevant studies, regardless of date, from inception to June 2023 was carried out and evaluated. After completing the electronic search and applying our inclusion/exclusion criteria, 6 studies—2 randomized control trials, 2 non-randomized studies, and 2 case series—were included. Data extraction of relevant articles was done independently by 2 authors. Quality assessment was done using the JBI prevalence critical appraisal tool and certainty of evidence was carried out by GRADE approach. Main Outcome Measures Nasolabial Aesthetics, Dentoalveolar Relationship. Results A total of six studies were included in the current review. Meta-analysis was carried out, and forest plots were obtained for a single mean from the lip-taping group. 3 studies had a low risk of bias, while 3 studies displayed a serious risk of bias. Significant improvement in various outcome measures was noted with lip taping when compared with the control group although the certainty of evidence was very low. Conclusion When compared to no therapy, lip taping appears to ameliorate dentoalveolar measurements and nasolabial aesthetics. To increase our knowledge of lip taping, more research will be needed in the future, as there are not many studies to prove lip taping is better than other treatment approaches.
Sound transmission loss optimization of clamped double-panels
Authors: Zhang Yumei , Li Ye , Xiao Xinbiao , Zhao Yue , Yao Dan , Ai Yi , Pan Weijun 
Published: May 2024

The panel cavity structure is one of the key components of the aircraft (vehicle) body and is among the main noise transmission pathways. Based on the modal superposition and Galerkin method, this paper realizes the theoretical model of sound insulation of the clamped, double-panel structure. The non-dominated sorting genetic algorithm-II (NSGA-II) is used to realize the sound insulation of the clamped double-panel structure. Through optimization, the fitting function and law of structural surface density and the optimized normal weighted sound insulation Pareto fronts were obtained. The results show that among the optimization, for the Pareto front cases, their double-panel thickness ratio h1/ h2 is relatively far away from 1, and the corresponding cavity thickness H is relatively large. The influence of boundary conditions and size effects of lightweight sound insulation optimization are also discussed. The research on the influence of boundary and size indicates that the difference in the optimal weighted sound insulation Pareto fronts corresponding to the same surface density is mostly within the 1 dB range. Both the boundary and thickness of the panel will affect the frequency STL, while the boundary conditions or structure size changed, even the total thickness of panels needs to be the same, and the structure can also have similar weighted sound transmission loss ( Rw) when the thickness ratio of the double-panel structure is chosen properly. The difference of material effects is also discussed. This research provides a method for the sound insulation optimization of clamped double-panel structures concerning the boundary and size effect.
Multiplatform web app (My Way Up) plus motivational interviewing for improving treatment retention in patients with onset of alcohol-related liver disease and alcohol use disorder – an example of participatory research
Authors: Caballeria Elsa , Balcells-Oliveró Mercè , Bataller Ramón , Bruguera Pol , Cabrera Noel , Estruch Alexandra , Freixa Neus , Garcia-Pañella Óscar , Graell Mireia , Gratacós-Gines Jordi , Guzman Pablo , Hernández-Rubio Anna , Lligoña Anna , Pérez-Guasch Martina , Pons-Cabrera María Teresa , Pose Elisa , Zuluaga Paola , López-Pelayo Hugo 
Published: May 2024

Background With the aim of improving treatment retention in patients with the onset of alcohol-related liver disease (ArLD), we designed a blended intervention (brief motivational intervention + ‘serious game’ (SG)). We present the participatory design methodology and outcomes and the usability assessment of the intervention. Methods (1) The design of the SG was based on the outcomes of two 3-h co-creation sessions with 37 participants (healthcare and technology professionals, patients, and patients’ relatives). The brief face-to-face motivational intervention was based on the 5 As Model and adapted to the ArLD population. (2) Usability pilot study: 20 participants (10 ArLD patients + 10 healthcare professionals) received the intervention. System Usability Scale (SUS) and Post-Study System Usability Questionnaire (PSSUQ) were applied to assess the SG usability and patients’ satisfaction with it. Weekly semi-structured interviews on the phone were conducted to identify the preferred elements in the SG and those aspects that should be improved. Results (1) Design: an SG in the form of a gamified web app, consisting of a daily activity for six weeks and adapted brief motivational interviewing. (2) Usability pilot study: usability results were excellent for both patients and healthcare professionals (SUS median score = 85). The general usability, the quality of the information provided by the SG and the quality of the interface were very positively rated in the PSSUQ (overall median score = 2, IQR = 1–2). The best-rated aspects were the provision of feedback, the use of metaphors and the application of audiovisual material. Changes in the design, response mechanics and content were applied after the study. Conclusions The usability and acceptability of an intervention for increasing retention to treatment in patients with recent onset of ArLD and AUD were excellent for patients and healthcare professionals. A randomized-controlled trial is required to test the efficacy of this approach.
Biomarkers to improve functional outcome prediction after ischemic stroke: Results from the SICFAIL, STRAWINSKI, and PREDICT studies
Authors: Montellano Felipe A , Rücker Viktoria , Ungethüm Kathrin , Penalba Anna , Hotter Benjamin , Giralt Marina , Wiedmann Silke , Mackenrodt Daniel , Morbach Caroline , Frantz Stefan , Störk Stefan , Whiteley William N , Kleinschnitz Christoph , Meisel Andreas , Montaner Joan , Haeusler Karl Georg , Heuschmann Peter U 
Published: May 2024

Background and aims: Acute ischemic stroke (AIS) outcome prognostication remains challenging despite available prognostic models. We investigated whether a biomarker panel improves the predictive performance of established prognostic scores. Methods: We investigated the improvement in discrimination, calibration, and overall performance by adding five biomarkers (procalcitonin, copeptin, cortisol, mid-regional pro-atrial natriuretic peptide (MR-proANP), and N-terminal pro-B-type natriuretic peptide (NT-proBNP)) to the Acute Stroke Registry and Analysis of Lausanne (ASTRAL) and age/NIHSS scores using data from two prospective cohort studies (SICFAIL, PREDICT) and one clinical trial (STRAWINSKI). Poor outcome was defined as mRS > 2 at 12 (SICFAIL, derivation dataset) or 3 months (PREDICT/STRAWINSKI, pooled external validation dataset). Results: Among 412 SICFAIL participants (median age 70 years, quartiles 59–78; 63% male; median NIHSS score 3, quartiles 1–5), 29% had a poor outcome. Area under the curve of the ASTRAL and age/NIHSS were 0.76 (95% CI 0.71–0.81) and 0.77 (95% CI 0.73–0.82), respectively. Copeptin (0.79, 95% CI 0.74–0.84), NT-proBNP (0.80, 95% CI 0.76–0.84), and MR-proANP (0.79, 95% CI 0.75–0.84) significantly improved ASTRAL score’s discrimination, calibration, and overall performance. Copeptin improved age/NIHSS model’s discrimination, copeptin, MR-proANP, and NT-proBNP improved its calibration and overall performance. In the validation dataset (450 patients, median age 73 years, quartiles 66–81; 54% men; median NIHSS score 8, quartiles 3–14), copeptin was independently associated with various definitions of poor outcome and also mortality. Copeptin did not increase model’s discrimination but it did improve calibration and overall model performance. Discussion: Copeptin, NT-proBNP, and MR-proANP improved modest but consistently the predictive performance of established prognostic scores in patients with mild AIS. Copeptin was most consistently associated with poor outcome in patients with moderate to severe AIS, although its added prognostic value was less obvious.
Multi-omics analysis revealed that the protein kinase MoKin1 affected the cellular response to endoplasmic reticulum stress in the rice blast fungus, Magnaporthe oryzae
Authors: Zhang Lianhu , Zhang Yifan , Liu Yankun , Miao Wenjing , Ai Jingyu , Li Jingling , Peng Song , Li Songyan , Ye Lifang , Zeng Rong , Shi Xugen , Ma Jian , Lin Yachun , Kuang Weigang , Cui Ruqiang 
Published: May 2024

Abstract
Background
Previous studies have shown that protein kinase MoKin1 played an important role in the growth, conidiation, germination and pathogenicity in rice blast fungus, Magnaporthe oryzae. ΔMokin1 mutant showed significant phenotypic defects and significantly reduced pathogenicity. However, the internal mechanism of how MoKin1 affected the development of physiology and biochemistry remained unclear in M. oryzae.

Result
This study adopted a multi-omics approach to comprehensively analyze MoKin1 function, and the results showed that MoKin1 affected the cellular response to endoplasmic reticulum stress (ER stress). Proteomic analysis revealed that the downregulated proteins in ΔMokin1 mutant were enriched mainly in the response to ER stress triggered by the unfolded protein. Loss of MoKin1 prevented the ER stress signal from reaching the nucleus. Therefore, the phosphorylation of various proteins regulating the transcription of ER stress-related genes and mRNA translation was significantly downregulated. The insensitivity to ER stress led to metabolic disorders, resulting in a significant shortage of carbohydrates and a low energy supply, which also resulted in severe phenotypic defects in ΔMokin1 mutant. Analysis of MoKin1-interacting proteins indicated that MoKin1 really took participate in the response to ER stress.

Conclusion
Our results showed the important role of protein kinase MoKin1 in regulating cellular response to ER stress, providing a new research direction to reveal the mechanism of MoKin1 affecting pathogenic formation, and to provide theoretical support for the new biological target sites searching and bio-pesticides developing.