bluuebunny/crossref_metadata_2025_split huggingface dataset:
PREDICTION OF SUCCESSFUL REVISION SURGERY FOR MESH-RELATED COMPLAINTS AFTER INGUINAL HERNIA AND PELVIC ORGAN PROLAPSE REPAIR
Authors: van Rest K L C , Gielen M J C A M , Warmerdam L M , Kowalik C R , Roovers J P W R , Zwaans W A R 
Published: May 2024

Abstract

Purpose
With this retrospective case series, we aim to identify predictors for reduction of pain after mesh revision surgery in patients operated for inguinal hernia or pelvic organ prolapse with a polypropylene implant. Identifying these predictors may aid surgeons to counsel patients and select appropriate candidates for mesh revision surgery.

Methods
Clinical records before and after mesh revision surgery from 221 patients with chronic postoperative inguinal pain (CPIP) and 59 patients with pain after pelvic organ prolapse (POP) surgery were collected at two experienced tertiary referral centers. Primary outcome was patient reported improvement of pain after revision surgery. A multivariable logistic regression model was used to specify predictors for pain reduction.

Results
The multivariable logistic regression was performed for each patient group separately. Patients with CPIP had higher chances of improvement of pain when time between mesh placement and mesh revision surgery was longer, with an OR of 1.19 per year. A turning point in chances of risks and benefits was demonstrated at 70 months, with improved outcomes for patients with revision surgery ≥70 months (OR 2.86). For POP patients, no statistically significant predictors for reduction of pain after (partial) removal surgery could be identified.

Conclusion
A longer duration of at least 70 months between implantation of inguinal mesh and revision surgery seems to give a higher chance on improvement of pain. Caregivers should not avoid surgery based on a longer duration of symptoms when an association between symptoms and the location of the mesh is found.
THE VERY FIRST EXPERIENCE WITH eTEP IN OUR DEPARTMENT
Authors: Woleský J , Jíšová B , East B 
Published: May 2024

Abstract

Background
Nowadays the main method everybody is talking about in ventral hernia repair is eTEP. The retromuscular hernia repair seems to be the gold standard for ventral hernias. The occurrence of ventral hernias is around 20% for primary and 30% for incisional hernias following the midline incisions. There is a surge of surgeons who are diving into this relatively new mini-invasive method. Until 2022 we performed only open ventral hernia repairs. Therefore, we have decided that we cannot be stuck "in the past" and started our long way of learning and improving in the eTEP field.

Method
We have run a retrospective trial looking at our small cohort of patients with ventral hernias that have undergone eTEP procedure at our department in the University hospital. We have specifically focused on the conversion rate to open surgery, possible complications, operating times, and postoperative complications.

Results
14 patients have successfully undergone the eTEP hernia repair. We had to convert 5 of those cases. The main surgical accident resulting in conversion was the perforation of peritoneum and entering the abdominal cavity. There were no sever complications and the most common postoperative complication was hematoma with no need of surgical revision.

Conclusion
Our first experience with the eTEP has been challenging and as the results show that we need to improve in many surgical categories. Especially in developing the retromuscular space. Also, lately we have managed to schedule easier cases with primary hernias and the results became better immediately.
OPEN REPAIR OF A LARGE VENTRAL HERNIA REQUIRING CAECOPEXY AND APPENDICECTOMY IN AN ELDERLY PATIENT
Authors: Zhao S , Abdulla M , Gerogiannis I 
Published: May 2024

Abstract

Aim
To present an interesting and challenging case of a large ventral hernia repair requiring caecopexy and appendectomy.

Material and Methods
An 83-year-old woman with hypothyroidism and hypertension but no other comorbidities presented to the outpatient clinic with a very large hernia which she said had been present for 20 years. On clinical examination the hernia was very large and irreducible containing bowel. The CT scan of the abdomen and pelvis showed a defect of 5 cm with a sac of 21 cm width containing loops of both large and small bowel including the entire right and transverse colon.
The procedure comprised skin incision followed by dissection of the sac from the skin and subcutaneous fat. The neck of the hernial sac was identified and opened. Safe entry into the abdomen. Minor adhesiolysis of the omentum from the sac. Small bowel was traced from the ileocaecal junction to the duodenojejunal flexure. Appendix identified and removed. Caecum and ascending colon were reduced in the peritoneal cavity and fixed to the lateral abdominal wall with non-absorbable sutures (caecopexy). Small and large bowel were placed in anatomical position. A small part of the omentum was removed. Rives-Stoppa technique was used. The right and left rectus sheaths were opened the posterior rectus sheath was identified and the retrorectus space was developed. Neurovascular bundles were identified and preserved. Dissection continued towards the xiphisternum and pubis.
The posterior rectus sheaths (right and left) were sutured together. A 30 × 30 lightweight microporous mesh was deployed into the retrorectus space. The anterior rectus sheath was closed with a non-absorbable suture. Haemostasis was achieved. 2 negative pressure 14 French drains were placed over the mesh in the retrorectus space. Another drain was placed in the subcutaneous space.

Results
The patient's post-operative course was uneventful, she remained in intensive care for 5 days and was discharged after 2 weeks of ward care. Her discharge was delayed due to the need for extensive physiotherapy. At 6 months follow-up, the patient was well and satisfied with the outcome of the procedure.

Conclusion
Ventral hernia repair in elderly patients can be challenging and have a long recovery, in some cases a combined intrabdominal approach is feasible with good outcomes. A surgeon with an interest and experience in abdominal wall surgery can offer a safe and efficient approach to these cases.
Localization of stuttering based on causal brain lesions
Authors: Theys Catherine , Jaakkola Elina , Melzer Tracy R , De Nil Luc F , Guenther Frank H , Cohen Alexander L , Fox Michael D , Joutsa Juho 
Published: May 2024

Abstract
Stuttering affects approximately 1 in 100 adults and can result in significant communication problems and social anxiety. It most often occurs as a developmental disorder but can also be caused by focal brain damage. These latter cases may lend unique insight into the brain regions causing stuttering.
Here, we investigated the neuroanatomical substrate of stuttering using three independent datasets: (i) case reports from the published literature of acquired neurogenic stuttering following stroke (n = 20, 14 males/six females, 16–77 years); (ii) a clinical single study cohort with acquired neurogenic stuttering following stroke (n = 20, 13 males/seven females, 45–87 years); and (iii) adults with persistent developmental stuttering (n = 20, 14 males/six females, 18–43 years). We used the first two datasets and lesion network mapping to test whether lesions causing acquired stuttering map to a common brain network. We then used the third dataset to test whether this lesion-based network was relevant to developmental stuttering.
In our literature dataset, we found that lesions causing stuttering occurred in multiple heterogeneous brain regions, but these lesion locations were all functionally connected to a common network centred around the left putamen, including the claustrum, amygdalostriatal transition area and other adjacent areas. This finding was shown to be specific for stuttering (PFWE &lt; 0.05) and reproducible in our independent clinical cohort of patients with stroke-induced stuttering (PFWE &lt; 0.05), resulting in a common acquired stuttering network across both stroke datasets. Within the common acquired stuttering network, we found a significant association between grey matter volume and stuttering impact for adults with persistent developmental stuttering in the left posteroventral putamen, extending into the adjacent claustrum and amygdalostriatal transition area (PFWE &lt; 0.05).
We conclude that lesions causing acquired neurogenic stuttering map to a common brain network, centred to the left putamen, claustrum and amygdalostriatal transition area. The association of this lesion-based network with symptom severity in developmental stuttering suggests a shared neuroanatomy across aetiologies.
Punishment, communities and assemblages
Authors: Ruggiero Vincenzo 
Published: May 2024

Abstract
Punishment is not only meted out in custodial institutions. It is also inflicted on ‘free’ individuals who experience harsh material conditions, violent institutional control or punitive responses to their political views and actions. This paper addresses punishment beyond the prison walls, where a variety of counter-hegemonic identities are moulded and where radical approaches to punishment are gestated. The argument is made that the abolitionist movement may find among those identities a range of potential allies for its campaigns. Key allies may also be found among community development activists and programmes.
Sustainability assessment of solar drying systems: a comparative life-cycle analysis of phase-change material-based vs. cylindrical solar dryers
Authors: Divyangkumar Nakum , Sharma Kirtika , Panwar N L , Saichandhu Gande 
Published: May 2024

Abstract
Solar drying systems are becoming a popular alternative to traditional energy-based drying systems for agricultural products due to their effectiveness and reduced fuel consumption. Although the efficiency of solar drying systems has been thoroughly investigated, their sustainability has not been studied enough. This study aims to fill that gap by conducting a life-cycle assessment of two new solar drying systems built in Udaipur, Rajasthan, India. The environmental implications of an innovative cylindrical solar-assisted drying system and a phase-change material-based solar drying system were evaluated using cradle-to-gate life-cycle analysis. The study uses the ReCiPe 2016 endpoints (H) technique to calculate various aspects such as midpoint, endpoint, single score, normalization result, and network diagram for phase-change material-based solar drying and cylindrical solar-assisted drying. Results show that phase-change material-based solar drying has an average of 40% more impact on the environment than cylindrical solar-assisted drying, with a high impact found in human non-carcinogenic toxicity, mainly due to the production of phase-change materials. However, cylindrical solar-assisted drying system crossover phase-change material based solar drying in terms of its impact on human carcinogenic toxicity and fossil resource scarcity. The contribution to global warming of phase-change material-based solar drying is 13.7% more than that of cylindrical solar-assisted drying. The endpoint characterization indicates that phase-change material-based solar drying exceeds in terms of human health (40%) and ecosystem (37.04%), whereas cylindrical solar-assisted drying surpasses phase-change material-based solar drying in terms of impacts on resources, at 14%. The early drying in phase-change material-based solar drying makes up for its higher impact than that in cylindrical solar-assisted drying, which takes 3 hours longer to dry. This study offers guidance and methods for making the best choice of solar-powered dryers.
SARS-CoV-2 Vaccination in the First Year After Hematopoietic Cell Transplant or Chimeric Antigen Receptor T-Cell Therapy: A Prospective, Multicenter, Observational Study
Authors: Hill Joshua A , Martens Michael J , Young Jo-Anne H , Bhavsar Kavita , Kou Jianqun , Chen Min , Lee Lik Wee , Baluch Aliyah , Dhodapkar Madhav V , Nakamura Ryotaro , Peyton Kristin , Howard Dianna S , Ibrahim Uroosa , Shahid Zainab , Armistead Paul , Westervelt Peter , McCarty John , McGuirk Joseph , Hamadani Mehdi , DeWolf Susan , Hosszu Kinga , Sharon Elad , Spahn Ashley , Toor Amir A , Waldvogel Stephanie , Greenberger Lee M , Auletta Jeffery J , Horowitz Mary M , Riches Marcie L , Perales Miguel-Angel 
Published: May 2024

Abstract

Background
The optimal timing of vaccination with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines after cellular therapy is incompletely understood. The objectives of this study are to determine whether humoral and cellular responses after SARS-CoV-2 vaccination differ if initiated &lt;4 months versus 4–12 months after cellular therapy.

Methods
We conducted a multicenter, prospective, observational study at 30 cancer centers in the United States. SARS-CoV-2 vaccination was administered as part of routine care. We obtained blood prior to and after vaccinations at up to 5 time points and tested for SARS-CoV-2 spike (anti-S) IgG in all participants and neutralizing antibodies for Wuhan D614G, Delta B.1.617.2, and Omicron B.1.1.529 strains, as well as SARS-CoV-2–specific T-cell receptors, in a subgroup.

Results
We enrolled 466 allogeneic hematopoietic cell transplantation (HCT) (n = 231), autologous HCT (n = 170), and chimeric antigen receptor T-cell (CAR-T-cell) therapy (n = 65) recipients between April 2021 and June 2022. Humoral and cellular responses did not significantly differ among participants initiating vaccinations &lt;4 months versus 4–12 months after cellular therapy. Anti-S IgG ≥2500 U/mL was correlated with high neutralizing antibody titers and attained by the last time point in 70%, 69%, and 34% of allogeneic HCT, autologous HCT, and CAR-T-cell recipients, respectively. SARS-CoV-2–specific T-cell responses were attained in 57%, 83%, and 58%, respectively. Pre–cellular therapy SARS-CoV-2 infection or vaccination and baseline B-cell count were key predictors of post–cellular therapy immunity.

Conclusions
These data support mRNA SARS-CoV-2 vaccination prior to, and reinitiation 3 to 4 months after, cellular therapies with allogeneic HCT, autologous HCT, and CAR-T-cell therapy.
Exploring the sex difference in cardiovascular risk during growth hormone therapy in adults
Authors: Slagboom Tessa N A , van der Lely Aart Jan , Drent Madeleine L , van Bunderen Christa C 
Published: May 2024

Abstract

Objective
Given the previously identified sex differences in cardiovascular (CV) morbidity and mortality in patients with growth hormone deficiency (GHD) receiving GH replacement therapy (GHRT), our aim is to investigate sex-specific differences in the efficacy of (long-term) GHRT on CV risk profile and disease in subjects with GHD. Our hypothesis is that women will experience less beneficial effects than men.

Design
Retrospective nationwide cohort study.

Methods
We compared all men (n = 1335) and women (n = 1251) with severe GHD registered in the Dutch National Registry of GH Treatment in Adults database with respect to CV risk profile and morbidity at baseline and during follow-up.

Results
Men had a more unfavourable CV risk profile at baseline. During the first years of GHRT, the reduction in waist circumference, waist-to-hip ratio, total cholesterol, and triglyceride levels was greater in men than in women (all P &lt; .05). Between-sex differences in effects during later follow-up were less clear. No sex differences were found in the risk of developing non-fatal cardiovascular or cerebrovascular diseases during GHRT.

Conclusions
Our results suggest that men with GHD did indeed experience more beneficial effects of GHRT on body composition and lipoprotein metabolism than women, at least in the early years of treatment. Also, the more unfavourable CV risk profile at baseline in men did not translate into a sex difference in the risk of developing CV and cerebrovascular morbidity during GHRT.
Telephone triage of chest pain in out-of-hours primary care: external validation of a symptom-based prediction rule to rule out acute coronary syndromes
Authors: Manten Amy , Harskamp Ralf E , Busschers Wim B , Moll van Charante Eric P , Himmelreich Jelle C L 
Published: May 2024

Abstract

Introduction
Telephone triage is pivotal for evaluating the urgency of patient care, and in the Netherlands, the Netherlands Triage Standard (NTS) demonstrates moderate discrimination for chest pain. To address this, the Safety First Prediction Rule (SFPR) was developed to improve the safety of ruling out acute coronary syndrome (ACS) during telephone triage.

Methods
We conducted an external validation of the SFPR using data from the TRACE study, a retrospective cohort study in out-of-hours primary care. We evaluated the diagnostic accuracy assessment for ACS, major adverse cardiovascular events (MACE), and major events within 6 weeks. Moreover, we compared its performance with that of the NTS algorithm.

Results
Among 1404 included patients (57.3% female, 6.8% ACS, 8.6% MACE), the SFPR demonstrated good discrimination for ACS (C-statistic: 0.79; 95%-CI: 0.75–0.83) and MACE (C-statistic: 0.79; 95%-CI: 0.0.76–0.82). Calibration was satisfactory, with overestimation observed in high-risk patients for ACS. The SFPR (risk threshold 2.5%) trended toward higher sensitivity (95.8% vs. 86.3%) and negative predictive value (99.3% vs. 97.6%) with a lower negative likelihood ratio (0.10 vs. 0.34) than the NTS algorithm.

Conclusion
The SFPR proved robust for risk stratification in patients with acute chest pain seeking out-of-hours primary care in the Netherlands. Further prospective validation and implementation are warranted to refine and establish the rule’s clinical utility.
Insights into ribosomal DNA dominance and magnification through characterization of isogenic deletion alleles
Authors: Kindelay Selina M , Maggert Keith A 
Published: May 2024

Abstract
The major loci for the large primary ribosomal RNA (rRNA) genes (35S rRNAs) exist as hundreds to thousands of tandem repeats in all organisms and dozens to hundreds in Drosophila. The highly repetitive nature of the ribosomal DNA (rDNA) makes it intrinsically unstable, and many conditions arise from the reduction in or magnification of copy number, but the conditions under which it does so remain unknown. By targeted DNA damage to the rDNA of the Y chromosome, we created and investigated a series of rDNA alleles. We found that complete loss of rDNA leads to lethality after the completion of embryogenesis, blocking larval molting and metamorphosis. We find that the resident retrotransposons—R1 and R2—are regulated by active rDNA such that reduction in copy number derepresses these elements. Their expression is highest during the early first instar, when loss of rDNA is lethal. Regulation of R1 and R2 may be related to their structural arrangement within the rDNA, as we find they are clustered in the flanks of the nucleolus organizing region (NOR; the cytological appearance of the rDNA). We assessed the complex nucleolar dominance relationship between X- and Y-linked rDNA using a histone H3.3–GFP reporter construct and incorporation at the NOR and found that dominance is controlled by rDNA copy number as at high multiplicity the Y-linked array is dominant, but at low multiplicity the X-linked array becomes derepressed. Finally, we found that multiple conditions that disrupt nucleolar dominance lead to increased rDNA magnification, suggesting that the phenomena of dominance and magnification are related, and a single mechanism may underlie and unify these two longstanding observations in Drosophila.
FLN-2 functions in parallel to linker of nucleoskeleton and cytoskeleton complexes and CDC-42/actin pathways during P-cell nuclear migration through constricted spaces in Caenorhabditis elegans
Authors: Ma Linda , Kuhn Jonathan , Chang Yu-Tai , Elnatan Daniel , Luxton G W Gant , Starr Daniel A 
Published: May 2024

Abstract
Nuclear migration through narrow constrictions is important for development, metastasis, and proinflammatory responses. Studies performed in tissue culture cells have implicated linker of nucleoskeleton and cytoskeleton (LINC) complexes, microtubule motors, the actin cytoskeleton, and nuclear envelope repair machinery as important mediators of nuclear movements through constricted spaces. However, little is understood about how these mechanisms operate to move nuclei in vivo. In Caenorhabditis elegans larvae, six pairs of hypodermal P cells migrate from lateral to ventral positions through a constricted space between the body wall muscles and the cuticle. P-cell nuclear migration is mediated in part by LINC complexes using a microtubule-based pathway and by an independent CDC-42/actin-based pathway. However, when both LINC complex and actin-based pathways are knocked out, many nuclei still migrate, suggesting the existence of additional pathways. Here, we show that FLN-2 functions in a third pathway to mediate P-cell nuclear migration. The predicted N-terminal actin-binding domain in FLN-2 that is found in canonical filamins is dispensable for FLN-2 function; this and structural predictions suggest that FLN-2 does not function as a filamin. The immunoglobulin-like repeats 4–8 of FLN-2 were necessary for P-cell nuclear migration. Furthermore, in the absence of the LINC complex component unc-84, fln-2 mutants had an increase in P-cell nuclear rupture. We conclude that FLN-2 functions to maintain the integrity of the nuclear envelope in parallel with the LINC complex and CDC-42/actin-based pathways to move P-cell nuclei through constricted spaces.
Projecting Long-Term Care Costs Among Older Adults With ADL Disabilities and Cognitive Impairment in China
Authors: Jin Haiyu , Wu Chenkai 
Published: May 2024

Abstract

Background
Mounting evidence suggests that cognitive impairment is strongly associated with disability in activities of daily living (ADL disability) and long-term care (LTC) costs. However, studies forecasting future LTC costs often overlook these relationships. Consequently, this study aims to more accurately project future LTC costs in China over the next 20 years by considering the intertwined association between disability and cognitive impairment on future LTC costs.

Methods
Data were from 10 959 adults ≥65 years from the 2005–2018 waves of the Chinese Longitudinal Healthy Longevity Surveys. We used the Markov model to project the population of China and track the transition of older adults in the next 20 years between 4 disability–cognition states. We employed a 2-part model to estimate LTC costs (direct and indirect LTC costs) per capita.

Results
The proportion of disabled older adults with cognitive impairment was projected to increase from 1.4% in 2021 to 3.4% in 2040, while that of those without cognitive impairment was projected to decrease from 4.7% in 2021 to 4.5% in 2040. The direct and indirect LTC costs were projected to increase from 0.3% and 0.2% of gross domestic product (GDP) in 2021 to 1.4% and 0.7% in 2040 for disabled persons without cognitive impairment and from 0.1% and 0.1% of GDP in 2021 to 1.3% and 1.3% in 2040 for those with cognitive impairment, respectively.

Conclusions
Policy-makers could include the assessment of cognition in the LTC needs assessment and allocate more compensation to LTC insurance participants with cognitive impairment.