bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards a functional model of website evaluation: a case study of casual dining restaurants
Authors: Gregory Amy , Wang Youcheng (Raymond) , DiPietro Robin B. 
Published: January 2010

PurposeThe purpose of this paper is to propose and apply a conceptual model that can be used to evaluate the functional performance of hospitality and tourism websites. This model will evaluate the websites from the perspective of information provision, communication, transactions, relationships, and technological merit, and how that applies to overall website functionality.Design/methodology/approachThe paper uses a case study methodology in order to evaluate a random sample of the top 400 casual dining restaurant chains of 2007. The casual dining restaurant segment is chosen because of its importance in the overall foodservice industry, as well as its predominant use of websites.FindingsRestaurant websites appear to be fairly strong in providing information in a technologically savvy environment. The areas that are found to be lower in functional efficiency are communication, relationship, and transaction. The three lowest‐rated individual attributes of the websites studied in the current research are the use and functionality of banners, reservations, and language on the websites.Research limitations/implicationsAs a case study, the limitations of this research are that the findings cannot be generalized to all restaurants because only a sample of casual dining chain restaurants is used. In addition, the model evaluated all of the components of the websites as being equal with the understanding that different website components weigh differently in their importance with consumers.Practical implicationsThe implications of the paper are critical for website developers and hospitality organizations as the analysis shows that there is still a gap between customer perceptions of restaurant websites and the potential to use the website to engage and connect with guests. The paper will give industry practitioners some insight into the perceptions regarding the usability of their websites in order to allow the organizations to make changes accordingly.Originality/valueThe paper is pioneering in developing and proposing a conceptual model of website evaluation and applying this theory‐supported conceptual model to the casual dining chain restaurants website evaluation.
An HR perspective: the global hunt for talent in the digital age
Authors: Dickson Duncan R. , Nusair Khaldoon 
Published: January 2010

PurposeThe purpose of this paper is to provide the reader with a practical understanding of the dynamic changes in how résumés are handled by recruiters and the application of technology to the human resource (HR) functions not only of reading résumés, but also of how technology is making some of the initial decisions on how they are passed on to hiring managers. HR information system has changed the way talent is accessed, prescreened, sorted, and stored. Knowledge of these systems is imperative for the twenty‐first century job‐seeker.Design/methodology/approachThe authors interview industry practitioners regarding the use of résumé scanning and identify the pros and cons of the systems from an industry perspective.FindingsThese discussions find that technology will continue to impact HR group in the hospitality industry. As the HR teams find more and better ways to utilize the technology the applicant pool will have to adjust to ensure that they are not screened out because they are missing a “key word.”Research limitations/implicationsThe ever changing technology makes the information dated immediately on publication. The implication is that the search and hiring process has changed so dramatically that awareness of technology is important.Practical implicationsRecruiters and job seekers must be aware of artificial intelligence, optical character recognition, and other scanning technologies. Understanding how technology is changing, even the most basic of HR practices is crucial.Originality/valueThe paper presents a discussion about the new technologies being used in the job search and résumé‐handling process, as well as the industry practitioner opinion of the uses and benefits of the technology.
Restaurants and technology – past, present and future: a practitioner's viewpoint
Authors: Doran Doug 
Published: January 2010

PurposeThe purpose of this paper is to provide a practitioner perspective on the impact of technology on restaurant operations.Design/methodology/approachThe paper reviews the development of technology and its application to restaurant operations, as viewed by a senior practitioner. It offers a viewpoint on the current state of development and the future developments that are needed and expected.FindingsThe paper cites significant examples of technological innovation over a period of some 30 years and discusses the impact of technology on restaurant operations, organization, and management.Practical implicationsThe paper aligns technological advances with the experiences of a senior professional's personal experience in operating and managing restaurants throughout a period of sustained technology change.Originality/valueThe paper offers a strategic viewpoint on the evolving nature of restaurant operations and the various ways in which technological innovation is driving new applications and change in the restaurant sector.
Weighing the option of biometrics in the hospitality industry
Authors: Warren Kelly 
Published: January 2010

PurposeThe purpose of this paper is to provide a practitioner perspective on the growing influence and impact of biometric technology on the hospitality industry.Design/methodology/approachThe paper outlines the different types of biometric authentication and its uses in hospitality operations and explores current and future applications in providing secure and safe guest services.FindingsThe paper cites examples of technological innovation and discusses the implications of biometric authentication for hospitality operations, organization, and management.Practical implicationsThe paper aligns technological advances with the experiences of a senior professional's personal experience in operating and managing restaurants.Originality/valueThe paper offers a strategic viewpoint on the potential range of applications for biometric verification and explores some of the complexities arising from its adoption and application to hospitality operations.
Summary
Authors: DiPietro Robin B. , Wang Youcheng (Raymond) 
Published: January 2010

PurposeThe purpose of this summary is to review the question: What have we learned about the impact of technology in hospitality operations?Design/methodology/approachThe summary considers the contribution made by each theme issue article to an overall understanding of the impact of technology – past, present and future – on human resource practices and in terms of monitoring guest satisfaction in hospitality operations.FindingsThe summary cites examples of technological innovation and discusses the implications of biometric authentication for hospitality operations, organization, and management.Practical implicationsThe paper summarizes the types of change that are being driven by developments in technology and comments on the operational implications.Originality/valueThe paper interlinks with the editorial and provides a concise review of the range of innovations that are continuing as a direct result of advances in technology.
Mechanisms of skin fibrosis in systemic sclerosis
Authors: JINNIN Masatoshi 
Published: January 2010

AbstractSystemic sclerosis (SSc) or scleroderma is an acquired disorder which typically results in fibrosis of the skin and internal organs. Skin fibrosis, the hallmark of this disease, is defined as excess deposition and accumulation of extracellular matrix, mainly type I collagen, in the dermis. Dermal fibroblasts isolated from lesional skin of SSc patients and culturedin vitroexhibit increased synthesis of collagen and decreased collagenase activity, consistent with the disease phenotype. This review focuses on the recent progress in the research for molecular mechanisms of skin fibrosis in SSc. The upregulated collagen production at transcriptional level in SSc fibroblasts involves various regulators including cytokines or transcription factors. Among them, transforming growth factor (TGF)‐β/Smad signaling is likely to play a key role in the pathogenesis of SSc, and the autocrine TGF‐β signaling hypothesis can explain intrinsic activation of collagen promoter in SSc fibroblasts. Imbalance between matrix metalloproteinases and tissue inhibitor of metalloproteinases might also contribute to the excess accumulation of collagen in the dermis.
Combinational effect of low‐dose oral corticosteroid and mizoribine for ulcerative colitis in a patient with systemic sclerosis
Authors: OHTSUKA Tsutomu 
Published: January 2010

AbstractThe combinational effect of oral corticosteroid and mizoribine for ulcerative colitis is presented in a patient with systemic sclerosis (SSc). A 64‐year‐old woman came to our clinic complaining of a 30‐year history of Raynaud’s phenomenon. She had past history of ulcerative colitis with the continued medication of mesalazine without success. She was presented with sclerodactyly and finger joint swelling. She also showed epigastric discomfort. Laboratory study showed positive anti‐nuclear antibody and positive anti‐centromere antibody. Histological examination showed mild perivascular mononuclear cell infiltrates in the whole dermis and increased deposition of collagen fibers in the middle and lower dermis. Chest X‐ray film showed mild bibasilar pulmonary fibrosis. An upper gastrointestinal series study showed reflux esophagitis and atrophic gastritis. These findings led to the diagnosis of systemic sclerosis (limited type) complicated with ulcerative colitis. Treatment with oral corticosteroid (5 mg/day) and mizoribine (150 mg/day) in the morning was started. She showed remarkable improvement for sclerodactyly and lower intestinal bleeding stopped after 6 months. She is under the same treatment without exaggeration and adverse effect of the drug until now.
Case of localized scleroderma successfully treated with bath psoralen and ultraviolet A therapy
Authors: UCHIYAMA Masaki , OKUBO Yukari , KAWASHIMA Hisashi , YAMAMOTO Kengo , MITSUHASHI Yoshihiko , TSUBOI Ryoji 
Published: January 2010

AbstractThe patient was a 12‐year‐old girl with linear scleroderma distributed on the right abdomen, dorsal aspect of the right thigh, lower leg and foot. The initial regimen of oral prednisolone and methotrexate, or i.v. methylprednisolone failed in the treatment of the scleroderma. Then bath psoralen and ultraviolet A therapy (bath‐PUVA) therapy of 0.2 J–4.0 J/cm2 daily to total doses 62.8 J/cm2 combined with oral prednisolone was started. After bath‐PUVA therapy, regression of the skin sclerosis was observed, the possible mobile range of the right ankle was increased and histological examination confirmed improvement of the sclerosis. The successful results of bath‐PUVA therapy in this case suggest its utility for localized scleroderma.
Case of localized scleroderma associated with osteomyelitis
Authors: MUROI Eiji , OGAWA Fumihide , YAMAOKA Toshifumi , SUEYOSHI Fumiko , SATO Shinichi 
Published: January 2010

AbstractWe report a 4‐year‐old girl presenting with progressive linear scleroderma affecting the right leg. Biopsy specimen disclosed typical histopathological findings of localized scleroderma. Right leg magnetic resonance imaging (MRI) showed high signal areas on T2‐weighted images on the subcutaneous fatty tissue, muscles and bone marrow, suggesting that skin inflammation extended to the bone marrow. Oral corticosteroid therapy was instituted with improvement of both skin sclerosis and MRI findings. Our observations suggest that MRI examination should be considered in patients with localized scleroderma to evaluate the extension of the inflammation.
Cutaneous polyarteritis nodosa: A report of 16 cases with clinical and histopathological analysis and a review of the published work
Authors: ISHIGURO Naoko , KAWASHIMA Makoto 
Published: January 2010

AbstractSixteen cases of cutaneous polyarteritis nodosa referred to our Department from 1985 to 2003 were studied clinically and histopathologically. Laboratory data, treatments and clinical courses were also evaluated retrospectively. All cases had nodules and/or indurated erythemas on their lower extremities. All cases showed necrotizing vasculitis of small muscular arteries in the subcutaneous tissues and/or occlusion of those arteries histopathologically. Fifteen cases also had accumulation of plasma protein in vessels of the dermis and subcutaneous tissues. Laboratory data showed high activity of platelets and coagulation in some cases. Eleven cases had been effectively treated with non‐steroidal anti‐inflammatory drugs. Eight cases were observed for at least 5 years (the longest for ∼19 years) and had good prognoses and no systemic involvement. Cutaneous polyarteritis nodosa seems to be a benign disease, and differs from systemic polyarteritis nodosa although their histopathological features are common. Cutaneous polyarteritis nodosa might involve local dysfunction of the circulation from the dermis to the subcutaneous area. A review of the published work shows that the cause(s) of most cases of cutaneous polyarteritis nodosa is unknown, that no controlled trials for treatment of cutaneous polyarteritis nodosa compared to polyarteritis nodosa have been reported, and that no definitively effective therapy for cutaneous polyarteritis nodosa has been established.
Case of livedoid vasculopathy with extensive dermal capillary thrombi
Authors: SHIMIZU Akira , TAMURA Atsushi , YAMANAKA Masayoshi , AMANO Hiroo , NAGAI Yayoi , ISHIKAWA Osamu 
Published: January 2010

AbstractLivedoid vasculopathy (LV) is thought to be a thrombogenic disorder. Here, we report a case of LV presenting livedo reticularis with leg ulcers clinically and many thrombogenic cutaneous vessels histologically. These features strongly suggested the presence of thrombogenic factors involved with the development of the lesions. After examination of various possible thrombogenic factors including phosphatidylserine‐dependent anti‐prothrombin antibody, we failed to detect any responsible thrombogenic factors for this case of LV. Recently, diverse thrombogenic factors have been reported to be involved in LV. This case may suggest that unknown thrombogenic factors are additionally related to LV pathogenesis.
Case of livedoid vasculopathy with peripheral neuropathy successfully treated with low‐dose warfarin
Authors: OSADA Shin‐Ichi , KIMURA Yoichi , KAWANA Seiji 
Published: January 2010

AbstractWe report herein a case of a 28‐year‐old woman with persistent livedo racemosa and recurrent ulcerations on the lower extremities. The clinical presentation, together with histopathological findings of vascular occlusion without overt vasculitis in the dermis, led to the diagnosis of livedoid vasculopathy. The patient experienced recurrence of ulcerations and developed peripheral neuropathy affecting the distal extremities during the course of treatment with sarpogrelate hydrochloride. The skin lesions and neurological symptoms improved dramatically after adding low‐dose warfarin potassium to the treatment regimen. This case suggests that administration of low‐dose warfarin is an effective therapy of choice for patients with livedoid vasculopathy.
Case of remitting seronegative symmetrical synovitis with pitting edema (RS3PE syndrome) showing dermatomyositis‐like eruption
Authors: TAKEDA Kiminobu , FUJITA Jun , FUJII Toshiki , TANABE Hiroshi , MOCHIZUKI Takashi , YANAGIHARA Makoto 
Published: January 2010

AbstractA 73‐year‐old woman developed linear erythema at the sites of scratching‐induced scars on the bilateral thighs 2 weeks before the initial consultation. Subsequently, edematous erythema developed in the upper eyelids, dorsum of the nose and the face, and pitting edema in the dorsum of the bilateral hands and feet. The C‐reactive protein (CRP) level was 8.2 mg/dL and erythrocyte sedimentation rate (ESR) 121 mm/h. The antinuclear antibody titer was 1:160, and rheumatoid factor (RF) and anti‐Jo‐1 antibody were negative. X‐ray examination of the bilateral hands showed neither narrowing of the joint spaces nor bone erosion. Ga scintigraphy showed synovitis of the bilateral wrists. A diagnosis of remitting seronegative symmetrical synovitis with pitting edema syndrome (RS3PE) was made. The erythema disappeared after diclofenac sodium administration. However, because the joint swelling and pitting edema did not improve, p.o. administration of prednisolone (20 mg/day) was initiated. The CRP and ESR levels normalized 2 months after the initiation of administration, and pitting edema disappeared after 3 months. We report this case because linear erythema like that observed in dermatomyositis has not been described as eruptions associated with RS3PE.
Pyoderma gangrenosum on the breast: A case presentation and review of the published work
Authors: MANSUR Ayşe Tülin , BALABAN Deniz , GÖKTAY Fatih , TAKMAZ Sezen 
Published: January 2010

AbstractWe present a case of pyoderma gangrenosum localized on the breast, without a preceding surgical intervention and associated systemic disorder. The ulcer had rapidly developed and covered a large portion of the breast. The patient responded well to systemic steroids and salicylazosulfapyridine and the ulcer completely healed with scarring after 3 months of treatment. Pyoderma gangrenosum rarely involves the breasts. A published work survey disclosed only 31 reported cases up to date. In most of these cases the lesions were related to previous surgical interventions, probably as the result of a pathergy phenomenon. The main differential diagnoses were skin and soft tissue infections including necrotizing fasciitis, and malignant neoplasms. Negative initial wound cultures and the relative sparing of nipple/areola complex helped to eliminate these disorders. Though an unusual site for pyoderma gangrenosum, lesions on the breast showed the characteristic clinical features of the disease. The types of associated disorders were also similar to those of the cases with classical pyoderma gangrenosum. As most of the lesions healed with significant scarring, early recognition and treatment of pyoderma gangrenosum located on the breast is important to prevent serious physical and psychological morbidity.
Future treatments in systemic sclerosis
Authors: ASANO Yoshihide 
Published: January 2010

AbstractSystemic sclerosis (SSc) is an autoimmune disorder with clinical manifestations resulting from immune activation, fibrosis development and damage of small blood vessels. Although there have been no established treatments for SSc, lots of new treatments targeting organ and pathogenesis are in the process of development. Transforming growth factor (TGF)‐β is a major cytokine involved in the pathogenesis of fibrosis in SSc. The blockade of cell surface molecules capable of activating latent TGF‐β, blockade of ligand by the pan‐isoform‐specific antibody, soluble TGF‐β receptors and a recombinant latency associated peptide, as well as inhibitors for ALK5 and Smad3 are the potential strategies to abolish the pathological activation of TGF‐β signaling in SSc fibroblasts. Besides TGF‐β, connective tissue growth factor (CTGF)/CCN2, platelet‐derived growth factor (PDGF) and endothelin‐1 are the candidates for the new therapeutic targets. As for immune dysfunction in SSc, i.v. immunoglobulin infusion, stem cell transplantation and B‐cell depletion are potential new therapies under or awaiting a randomized, double‐blind, placebo‐controlled trial, although their efficacies are still controversial. Phosphodiesterase‐5 inhibitors, endothelin receptor antagonists and inhibitors for serotonin signaling are the new therapeutic targets for Raynaud’s phenomenon, digital ulceration and pulmonary arterial hypertension in SSc. Imatinib mesylate may be a novel new therapy for fibrosis and vasculopathy in SSc because it reverses the expression levels ofFli1, which is a transcription factor downregulated in SSc through an epigenetic mechanism and is likely to be involved in the development of fibrosis and vasculopathy in this disease. Potential therapeutic targets other than those described above are also reviewed.
Autoantibody profiles in systemic sclerosis: Predictive value for clinical evaluation and prognosis
Authors: HAMAGUCHI Yasuhito 
Published: January 2010

AbstractSystemic sclerosis (SSc) is thought to be an autoimmune disease, as autoantibodies against a variety of extractable nuclear antigens can be detected in patient sera. Subgrouping patients based on the type of autoantibodies present can be useful in diagnosis and management. Anti‐centromere antibodies (ACA) and anti‐topoisomerase I antibodies (anti‐topo I) are the classic autoantibodies associated with SSc. ACA are associated with limited cutaneous involvement and isolated pulmonary hypertension, whereas anti‐topo I are associated with diffuse skin involvement and pulmonary fibrosis. ACA are predictors for a favorable prognosis, while anti‐topo I are correlated with a poor prognosis and SSc‐related mortality. Additionally, anti‐RNA polymerase antibodies (anti‐RNAP) are associated with diffuse cutaneous disease and renal involvement. Anti‐nucleolar antibodies define multiple subgroups of patients with SSc. Of these, anti‐Th/To antibodies (anti‐Th/To) and anti‐PM‐Scl antibodies (anti‐PM‐Scl) are associated with limited cutaneous SSc (lSSc), whereas anti‐U3RNP antibodies (anti‐U3RNP) are associated with diffuse cutaneous SSc (dSSc). In addition, anti‐Th/To and anti‐U3RNP can be predictors for a less favorable prognosis with a higher frequency of organ involvement, such as pulmonary fibrosis, pulmonary hypertension and renal crisis. Other autoantibodies are less frequently reported: anti‐Ku antibodies, anti‐U1RNP antibodies, anti‐human upstream‐binding factor, and anti‐U11/U12 antibodies. These antibodies are generally less specific to SSc, but also define clinically distinct patient subsets. Thus, characterization of autoantibodies in SSc together with knowledge of disease characteristics intrinsic to distinct patient populations is helpful for assessing the clinical presentation and prognosis of this disease, and for monitoring patients with SSc.
B lymphocytes: Shedding new light on the pathogenesis of systemic sclerosis
Authors: HASEGAWA Minoru 
Published: January 2010

AbstractSystemic sclerosis (SSc) is a connective tissue disease characterized by autoimmunity and tissue fibrosis. In patients with SSc, there is a close association between the presence of specific autoantibodies and the development of clinical features. Although it is known that cytokines, including transforming growth factor‐β, can modulate the synthesis of extracellular matrix by fibroblasts, it is not clear how autoimmunity and tissue fibrosis are interrelated. Several recent lines of evidence indicate a potential role for B cells in the development of SSc. CD19 is a critical regulator of B‐cell signaling thresholds, and B cells from SSc patients exhibit increased expression of CD19, a molecule that induces SSc‐specific autoantibody production in transgenic mice. Both SSc patients and tight‐skin mice, a genetic model of SSc, have intrinsic B‐cell abnormalities characterized by chronic B‐cell activation. Remarkably, CD19 loss or B‐cell depletion using antimouse CD20 antibody suppresses the development of skin hyperplasia and autoimmunity in tight‐skin mice. Additionally, a recent study revealed a possible beneficial effect of antihuman CD20 antibody (rituximab) therapy for SSc patients. As B cells have a variety of functions, further investigation into the pathogenic roles of B cells, as well as trials of B‐cell‐targeting therapies, may shed new light on the pathogenesis of SSc.