bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hand-foot syndrome in cancer patients on capecitabine: examining prevalence, impacts, and associated risk factors at a cancer centre in Malaysia
Authors: King Teck Long , Voon Pei Jye , Yuen Kah Hay , Mohamed Noor Dzul Azri 
Published: May 2024

Abstract
Introduction
Hand-foot syndrome (HFS) significantly impacts quality of life in cancer patients undergoing capecitabine treatment. This study assessed capecitabine-associated HFS prevalence, its impacts on chemotherapy treatment, and identified risk factors in multiracial Malaysian patients.

Methods
We included adult cancer patients receiving capecitabine at Sarawak General Hospital for at least two cycles from April 1, 2021 to June 30, 2022. HFS rates, time to HFS, and proportions of HFS-related treatment modifications were determined. Characteristics between patients with and without HFS were compared and multivariable logistic regression was used to identify risk factors for all-grade HFS and grade ≥2.

Results
Among 369 patients, 185 (50.1%) developed HFS, with 14.6% experiencing grade ≥2 and 21.6% (40/185) underwent treatment modifications. Risk factors for all-grade HFS include older age (OR 1.03 95%CI 1.01, 1.06), prior chemotherapy (OR 2.09 95%CI 1.22, 3.58), higher capecitabine dose (OR 2.96 95%CI 1.62, 5.38), prolonged treatment (OR 1.36 95%CI 1.21, 1.51), folic acid intake (OR 3.27 95%CI 1.45, 7.35) and lower neutrophil count (OR 0.77 95%CI 0.66, 0.89). For HFS grade ≥2, older age (OR 1.04 95%CI 1.01, 1.08), female sex (OR 2.10 95%CI 1.05, 4.18), Chinese race (OR 2.10 95%CI 1.06, 4.18), and higher capecitabine dose (OR 2.62 95%CI 1.28, 5.35) are significant risk factors. Use of calcium channel blockers were associated with reduced risks of all-grade HFS (OR 0.27, 95%CI 0.12, 0.60) and grade ≥2 (OR 0.21 95%CI 0.06, 0.78).

Conclusion
This study provides real-world data on capecitabine-induced HFS in Malaysian patients and identifies risk factors that may offer insights into its understanding and management.
Longitudinal assessment of real-world patient adherence: a 12-month electronic patient-reported outcomes follow-up of women with early breast cancer undergoing treatment
Authors: Gebert Pimrapat , Hage Anna Maria , Blohmer Jens-Uwe , Roehle Robert , Karsten Maria Margarete 
Published: May 2024

Abstract
Background
Electronic patient-reported outcomes (ePROs) assess patients’ health status and quality of life, improving patient care and treatment effects, yet little is known about their use and adherence in routine patient care.

Aims
We evaluated the adherence of invasive breast cancer and ductal carcinoma in situ (DCIS) patients to ePROs follow-up and whether specific patient characteristics are related to longitudinal non-adherence.

Methods
Since November 2016, the Breast Center at Charité – Universitätsmedizin Berlin has implemented an ongoing prospective PRO routine program, requiring patients to complete ePROs assessments and consent to email-based follow-up in the first 12 months after therapy starts. Frequencies and summary statistics are presented. Multiple logistic regression models were performed to determine an association between patient characteristics and non-adherence.

Results
Out of 578 patients, 239 patients (41.3%, 95%CI: 37.3–45.5%) completed baseline assessment and all five ePROs follow-up during the first 12 months after therapy. On average, above 70% of those patients responded to the ePROs follow-up assessment. Adherence to the ePROs follow-up was higher during the COVID-19 pandemic than in the time periods before (47.4% (111/234) vs. 33.6% (71/211)). Factors associated with longitudinal non-adherence were younger age, a higher number of comorbidities, no chemotherapy, and a low physical functioning score in the EORTC QLQ-C30 at baseline.

Conclusions
The study reveals moderate adherence to 12-month ePROs follow-up assessments in invasive early breast cancer and DCIS patients, with response rates ranging from 60 to 80%. Emphasizing the benefits for young patients and those with high disease burdens might further increase adherence.
Network security AIOps for online stream data monitoring
Authors: Nguyen Giang , Dlugolinsky Stefan , Tran Viet , López García Álvaro 
Published: May 2024

AbstractIn cybersecurity, live production data for predictive analysis pose a significant challenge due to the inherently secure nature of the domain. Although there are publicly available, synthesized, and artificially generated datasets, authentic scenarios are rarely encountered. For anomaly-based detection, the dynamic definition of thresholds has gained importance and attention in detecting abnormalities and preventing malicious activities. Unlike conventional threshold-based methods, deep learning data modeling provides a more nuanced perspective on network monitoring. This enables security systems to continually refine and adapt to the evolving situation in streaming data online, which is also our goal. Furthermore, our work in this paper contributes significantly to AIOps research, particularly through the deployment of our intelligent module that cooperates within a monitoring system in production. Our work addresses a crucial gap in the security research landscape toward more practical and effective secure strategies.
How should cardiac xenotransplantation be initiated in Japan?
Authors: Saito Shunsuke , Miyagawa Shuji , Kawamura Takuji , Yoshioka Daisuke , Kawamura Masashi , Kawamura Ai , Misumi Yusuke , Taguchi Takura , Yamauchi Takashi , Miyagawa Shigeru 
Published: May 2024

AbstractThe world's first clinical cardiac xenotransplantation, using a genetically engineered pig heart with 10 gene modifications, prolonged the life of a 57-year-old man with no other life-saving options, by 60 days. It is foreseeable that xenotransplantation will be introduced in clinical practice in the United States. However, little clinical or regulatory progress has been made in the field of xenotransplantation in Japan in recent years. Japan seems to be heading toward a "device lag", and the over-importation of medical devices and technology in the medical field is becoming problematic. In this review, we discuss the concept of pig-heart xenotransplantation, including the pathobiological aspects related to immune rejection, coagulation dysregulation, and detrimental heart overgrowth, as well as genetic modification strategies in pigs to prevent or minimize these problems. Moreover, we summarize the necessity for and current status of xenotransplantation worldwide, and future prospects in Japan, with the aim of initiating xenotransplantation in Japan using genetically modified pigs without a global delay. It is imperative that this study prompts the initiation of preclinical xenotransplantation research using non-human primates and leads to clinical studies.
Social determinants of antidepressant continuation during pregnancy in the USA: findings from the ABCD cohort study
Authors: Dupuis Marc , Weir Kristie Rebecca , Vidonscky Lüthold Renata , Panchaud Alice , Baggio Stéphanie 
Published: May 2024

Abstract
Purpose
Patients and healthcare professionals overestimate the risks of using antidepressants during pregnancy. According to current literature, approximately half of people stop taking an anti-depressant medication when they become pregnant. Discontinuing antidepressants during pregnancy increases risks of postnatal relapses. Factors like socioeconomic status, education, and planned pregnancies play a role in the decision to continue antidepressant medication, which can worsen disparities in maternal and child health. Our aim was to identify the sociodemographic factors associated with antidepressant continuation after awareness of pregnancy.

Methods
We used representative data from the Adolescent Brain Cognitive Development (ABCD) study that captures maternal medication during pregnancy. We identified women who used antidepressants before awareness of their pregnancy. We calculated crude and adjusted associations between sociodemographic factors and continuation of antidepressant medication during pregnancy. Our model included age, education, ethnicity, first language, household income, living with a partner, having planned the pregnancy, pregnancy duration and smoking during pregnancy.

Results
In total, 199 women continued antidepressants and 100 discontinued. The logistic regressions resulted in only one significant factor: first language. Native English speakers were more likely to continue medication than other mothers (adjusted OR = 14.94, 95% CI = [2.40; 291.45], p = .015).

Conclusions
Language differences were associated with continuation of antidepressants. Non-native English speakers were more likely to discontinue antidepressants, which may lead to health inequities. This finding should be taken into account to reinforce information about the limited risks of antidepressants among people with non-English speaking backgrounds in the USA.
Resin infiltration versus fluoride varnish for visual improvement of white spot lesions during multibracket treatment. A randomized-controlled clinical trial
Authors: Kashash Yamen , Hein Sascha , Göstemeyer Gerd , Aslanalp Pervin , Weyland Manon Isabelle , Bartzela Theodosia 
Published: May 2024

Abstract
Aims
This study aimed to evaluate the visual improvement of resin infiltration of white spot lesions (WSL) during orthodontic treatment with the multibracket appliance (MBA) compared to fluoride varnish.

Methods
Patients aged 12–17 years with at least one WSL with an International Caries Detection and Assessment System (ICDAS) score of 1–2 during an active MBA treatment were included and randomized to receive either resin infiltration (Icon) or fluoride application (Flairesse). Standardized digital images were obtained before, one-day, one-week, one-month, three-months and six-months after treatment using a DSLR camera and a matching polarization filter. A grey reference card was used for color standardization. A Matlab routine was used to measure the color difference between adjacent healthy enamel and treated WSL. The independent-samples t-test was used for intergroup and paired-samples t-test for intragroup comparison.

Results
Images of 116 teeth from 36 patients were analyzed. The ΔE for the “Icon” treated WSL was smaller (T1ICON = 5.0 ± 1.4) than in the fluoride group (T1Fluoride = 8.4 ± 3.2). Caries infiltration significantly improved the aesthetic appearance of WSL (p < 0.001), which remained satisfactory at six months (T5ICON = 5.2 ± 1.6).

Conclusion
WSL infiltration management during orthodontic treatment was superior to topical fluoridation in not only arresting the enamel lesions but also significantly improving the aesthetic appearance of demineralized regions around the brackets.

Clinical relevance
WSL treatment in orthodontic patients is usually initiated after debonding. Research has shown that the earlier WSL is treated, the better the aesthetic outcome. There is limited data on the efficacy of resin infiltration of WSL during orthodontic treatment.
Treatment strategy for HER2-negative advanced gastric cancer: salvage-line strategy for advanced gastric cancer
Authors: Nishida Naohiro , Sakai Daisuke , Satoh Taroh 
Published: May 2024

AbstractAfter immune checkpoint inhibitor (ICI) comes into third-line treatment of advanced gastric cancer, the therapeutic strategy has been dramatically changed. Recent first-line regimen, which consists of ICI and chemotherapeutic agents, prolonged progression-free survival, and subsequent treatment options enabled continuous treatment beyond second-line therapy. Moreover, the advent of vascular endothelial growth factor (VEGF)-targeted agents including angiogenesis inhibitors and TKIs provides an opportunity of considering the interaction between ICI and anti-VEGF agents, and facilitating novel treatment proposal. Although clinical benefit of prolonged VEGF blockade after disease progression has not been confirmed in gastric cancer, combination therapy of cytotoxic agents and anti-VEGF agent, such as irinotecan plus ramucirumab demonstrated favorable objective response rate and progression-free survival in third- or later-line setting. In this review, we discuss recent progress and future directions of later-line treatments of HER2-negative advancer gastric cancer.
Genetic differentiation of wild boar populations in a region affected by African swine fever
Authors: Simon Uta , Gerhards K , Becker S , Willems H , Friedrichs V , Forth JH , Calvelage S , Blome S , Reiner Gerald 
Published: May 2024

AbstractIn the European Union, African swine fever (ASF) affects wild boar (Sus scrofa) populations in several Member States. Knowledge of population connectivity is important for the implementation of control measures, in particular the establishment of effective barriers. Population genetic comparisons of neighbouring populations can be very helpful in this respect. The present study investigated the genetic differentiation of wild boar in eastern Germany. This region has been affected by ASF since September 2020. A total of 1,262 wild boars from 31 hunting grounds (populations) in ASF-affected and ASF-free districts were sampled over a total area of almost 100,000 km². The study area encompassed a network of geographical factors that promote (roads, rivers, cities) or inhibit (natural areas, habitat corridors) genetic differentiation between wild boar populations. The genetic differentiation of the areas was based on 12 microsatellite markers. Three different Bayesian algorithms were used to analyse the data. The results were combined into a common approach with 9 clusters. Based on the cluster distribution in each population, the connectivity between the areas was quantified. The strongest differentiation was found along an imaginary line along the lower Elbe valley through Berlin and the A11 freeway to the Szczecin Lagoon. In contrast, the Mecklenburg Lake District and the south-east of the study area showed strong connectivity between areas. The special features of the landscapes along the lower Elbe valley, which was assessed as highly connective, and the high barrier effect of the A11 freeway in contrast to the other freeways in the study area show that barrier effects cannot be generalised in principle, but are actually determined by the circumstances of individual structures. The results of the connectivity analysis were compared with the distribution of viral lineages and variants. The genotypes of the wild boar populations and the ASFV lineages and variants showed a good explanatory approach for the observed disease dynamics in the study area. The newly gained knowledge on barriers and regionally different connectivity between wild boar populations can support considerations and measures for the containment of ASF in the affected areas by improving the understanding of wild boar dispersal dynamics.
Incivility is systematically associated with indicators of health, stress, well-being, and the psychosocial work environment
Authors: Hasson Dan , Villaume Karin 
Published: May 2024

Abstract
Aim
Incivility is one of the most intrusive forms of antisocial behavior in the workplace. Using a newly constructed, single-item measure of incivility, the aim of the current study was to assess the possible prevalence of incivility in a sample from the Swedish retail industry, and to investigate possible associations between prevalence of incivility and a multitude of indicators of health, stress, well-being, and the psychosocial work environment.

Subject and methods
A total of 1014 (20%) individuals enrolled in the cross-sectional study and responded to a questionnaire, partially or fully. We conducted t-tests to assess possible differences in the indicators between those responding “Yes” versus “No” regarding prevalence of incivility at their workplace.

Results
Incivility at work was related to statistically significant differences in mean values in 32 out of 33 key indicators of health, well-being, stress, recovery, and the psychosocial work environment. Those reporting a prevalence of incivility systematically exhibited worse ratings.

Conclusion
The findings are in line with previous research. Although this study cannot infer causality, the profoundly systematic results indicate that the prevalence of workplace incivility is a bothersome problem that should be addressed. A single item about the prevalence of workplace incivility seems to be a feasible indicator of associations to a wide range of health-, stress-, well-being-, and psychosocially oriented work-related variables.
Clinical and genetic characteristics of carriers of the TP53 c.541C > T, p.Arg181Cys pathogenic variant causing hereditary cancer in patients of Arab-Muslim descent
Authors: Arnon Johnathan , Zick Aviad , Maoz Myriam , Salaymeh Nada , Gugenheim Ahinoam , Marouani MazalTov , Mor Eden , Hamburger Tamar , Saadi Nagam , Elia Anna , Ganz Gael , Fahham Duha , Meirovitz Amichay , Kadouri Luna , Meiner Vardiella , Yablonski-Peretz Tamar , Shkedi-Rafid Shiri 
Published: May 2024

AbstractTP53 pathogenic variants cause Li-Fraumeni syndrome (LFS), with some variants causing an attenuated phenotype. Herein, we describe the clinical phenotype and genetic characteristics of carriers of NM_000546.6 (TP53): c.541C > T, (p.Arg181Cys) treated at Hadassah Medical Center. We retrospectively examined our genetic databases to identify all carriers of TP53 p.Arg181Cys. We reached out to carriers and their relatives and collected clinical and demographic data, lifestyle factors, carcinogenic exposures as well as additional blood samples for genetic testing and whole exome sequencing. Between 2005 and 2022 a total of 2875 cancer patients underwent genetic testing using genetic panels, whole exome sequencing or targeted TP53 assays. A total of 30 cancer patients, all of Arab-Muslim descent, were found to be carriers of TP53 p.Arg181Cys, the majority from Jerusalem and Hebron, two of which were homozygous for the variant. Carriers were from 24 distinct families of them, 15 families (62.5%) met updated Chompret criteria for LFS. Median age of diagnosis was 35 years-old (range 1–69) with cancers characteristic of LFS (16 Breast cancer; 6 primary CNS tumors; 3 sarcomas) including 4 children with choroid plexus carcinoma, medulloblastoma, or glioblastoma. A total of 21 healthy carriers of TP53 p.Arg181Cys were identified at a median age of 39 years-old (range 2–54)—19 relatives and 2 additional pediatric non-cancer patients, in which the finding was incidental. We report a shared haplotype of 350kb among carriers, limited co-morbidities and low BMI in both cancer patients and healthy carriers. There were no demographic factors or carcinogenic exposures unique to carriers who developed malignancy. Upon exome analysis no other known pathogenic variants in cancer predisposing genes were identified. TP53 p.Arg181Cys is a founder pathogenic variant predominant to the Arab-Muslim population in Jerusalem and Hebron, causing attenuated-LFS. We suggest strict surveillance in established carriers and encourage referral to genetic testing for all cancer patients of Arab-Muslim descent in this region with LFS-associated malignancies as well as family members of established carriers.
Screening for pancreatic cancer in high-risk individuals using MRI: optimization of scan techniques to detect small lesions
Authors: Boekestijn Bas , Feshtali Shirin , Vasen Hans , van Leerdam Monique E. , Bonsing Bert A. , Mieog J. Sven D. , Wasser Martin N. 
Published: May 2024

AbstractPancreatic cancer has a dismal prognosis in the general population. However, early detection and treatment of disease in high-risk individuals can improve survival, as patients with localized disease and especially patients with lesions smaller than 10 mm show greatly improved 5-year survival rates. To achieve early detection through MRI surveillance programs, optimization of imaging is required. Advances in MRI technologies in both hardware and software over the years have enabled reliable detection of pancreatic cancer at a small size and early stage. Standardization of dedicated imaging protocols for the pancreas are still lacking. In this review we discuss state of the art scan techniques, sequences, reduction of artifacts and imaging strategies that enable early detection of lesions. Furthermore, we present the imaging features of small pancreatic cancers from a large cohort of high-risk individuals. Refinement of MRI techniques, increased scan quality and the use of artificial intelligence may further improve early detection and the prognosis of pancreatic cancer in a screening setting.
Early stress exposure on zebrafish development: effects on survival, malformations and molecular alterations
Authors: Valcarce David G. , Sellés-Egea Alba , Riesco Marta F. , De Garnica María-Gracia , Martínez-Fernández Beatriz , Herráez María Paz , Robles Vanesa 
Published: May 2024

AbstractThe effects of stress during early vertebrate development can be especially harmful. Avoiding stressors in fish larvae is essential to ensure the health of adult fish and their reproductive performance and overall production. We examined the consequences of direct exposure to successive acute stressors during early development, including their effects on miR-29a and its targets, survival, hatching and malformation rates, larval behaviour and cartilage and eye development. Our aim was to shed light on the pleiotropic effects of early-induced stress in this vertebrate model species. Our results showed that direct exposure to successive acute stressors during early development significantly upregulated miR-29a and downregulated essential collagen transcripts col2a1a, col6a2 and col11a1a, decreased survival and increased malformation rates (swim bladder, otoliths, cardiac oedema and ocular malformations), promoting higher rates of immobility in larvae. Our results revealed that stress in early stages can induce different eye tissular architecture and cranioencephalic cartilage development alterations. Our research contributes to the understanding of the impact of stressful conditions during the early stages of zebrafish development, serving as a valuable model for vertebrate research. This holds paramount significance in the fields of developmental biology and aquaculture and also highlights miR-29a as a potential molecular marker for assessing novel larval rearing programmes in teleost species.