bluuebunny/crossref_metadata_2025_split huggingface dataset:
Solution‐Processed Ultralow Voltage Organic Transistors With Sharp Switching for Adaptive Visual Perception
Authors: Duan Shuming , Zhang Xianghong , Xi Yue , Liu Di , Zhang Xiaotao , Li Chunlei , Jiang Lang , Li Liqiang , Chen Huipeng , Ren Xiaochen , Hu Wenping 
Published: May 2024

AbstractNeuromorphic visual systems can emulate biological retinal systems to perceive visual information under different levels of illumination, making them have considerable potential for future intelligent vehicles and vision automation. However, the complex circuits and high operating voltages of conventional artificial vision systems present great challenges for device integration and power consumption. Here, bioinspired synaptic transistors based on organic single crystal phototransistors are reported, which exhibit excitation and inhibition synaptic plasticity with time‐varying. By manipulating the charge dynamics of the trapping centers of organic crystal–electret vertical stacks, organic transistors can operate below 1 V with record high on/off ratios close to 108 and sharp switching with a subthreshold swing of 59.8 mV dec−1. Moreover, the approach offers visual adaptation with highly localized modulation and over 98.2% recognition accuracy under different illumination levels. These bioinspired visual adaptation transistors offer great potential for simplifying the circuitry of artificial vision systems and will contribute to the development of machine vision applications.
The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by Regulating SRSF9‐Mediated Splicing of NFATc4
Authors: Yu Shuting , Sun ZhiYong , Ju Tiantian , Liu Yingqi , Mei Zhongting , Wang Changhao , Qu Zhezhe , Li Na , Wu Fan , Liu KuiWu , Lu Meixi , Huang Min , Pang Xiaochen , Jia Yingqiong , Li Ying , Zhang Yaozhi , Dou Shunkang , Jiang Jianhao , Dong Xianhui , Huang Chuanhao , Li Wanhong , zhang Yi , Yuan Ye , Yang Baofeng , Du Weijie 
Published: May 2024

AbstractCardiac hypertrophy is a key factor driving heart failure (HF), yet its pathogenesis remains incompletely elucidated. Mettl1‐catalyzed RNA N7‐methylguanosine (m7G) modification has been implicated in ischemic cardiac injury and fibrosis. This study aims to elucidate the role of Mettl1 and the mechanism underlying non‐ischemic cardiac hypertrophy and HF. It is found that Mettl1 is upregulated in human failing hearts and hypertrophic murine hearts following transverse aortic constriction (TAC) and Angiotensin II (Ang II) infusion. YY1 acts as a transcriptional factor for Mettl1 during cardiac hypertrophy. Mettl1 knockout alleviates cardiac hypertrophy and dysfunction upon pressure overload from TAC or Ang II stimulation. Conversely, cardiac‐specific overexpression of Mettl1 results in cardiac remodeling. Mechanically, Mettl1 increases SRSF9 expression by inducing m7G modification of SRSF9 mRNA, facilitating alternative splicing and stabilization of NFATc4, thereby promoting cardiac hypertrophy. Moreover, the knockdown of SRSF9 protects against TAC‐ or Mettl1‐induced cardiac hypertrophic phenotypes in vivo and in vitro. The study identifies Mettl1 as a crucial regulator of cardiac hypertrophy, providing a novel therapeutic target for HF.
Innovative Energy Storage Smart Windows Relying on Mild Aqueous Zn/MnO2 Battery Chemistry
Authors: Palamadathil Kannattil Hamid , Martinez Soria Gallo Lluis , Harris Kenneth D. , Limoges Benoît , Balland Véronique 
Published: May 2024

AbstractRechargeable mild aqueous Zn/MnO2 batteries are currently attracting great interest thanks to their appealing performance/cost ratio. Their operating principle relies on two complementary reversible electrodeposition reactions at the anode and cathode. Transposing this operating principle to transparent conductive windows remains an unexplored facet of this battery chemistry, which is proposed here to address with the development of an innovative bifunctional smart window, combining electrochromic and charge storage properties. The proof‐of‐concept of such bifunctional Zn/MnO2 smart window is provided using a mild buffered aqueous electrolyte and different architectures. To maximize the device's performance, transparent nanostructured ITO cathodes are used to reversibly electrodeposit a high load of MnO2 (up to 555 mA h m−2 with a CE of 99.5% over 200 cycles, allowing to retrieve an energy density as high as 860 mA h m−2 when coupled with a zinc metal frame), while flat transparent FTO anodes are used to reversibly electrodeposit an homogenous coating of zinc metal (up to ≈280 mA h m−2 with a CE > 95% over 50 cycles). The implementation of these two reversible electrodeposition processes in a single smart window has been successfully achieved, leading for the first time to a dual‐tinting energy storage smart window with an optimized face‐to‐face architecture.
Identifying Radical Pathways for Cu(I)/Cu(II) Relay Catalyzed Oxygenation via Online Coupled EPR/UV–Vis/Near‐IR Monitoring
Authors: Wang Yongtao , Zhou Yujia , Sun Wenjing , Wang Xinyu , Yao Jia , Li Haoran 
Published: May 2024

AbstractCopper‐catalyzed C─H oxygenation has drawn considerable attention in mechanistic studies. However, a comprehensive investigation combining radical pathways with a metal‐catalytic cycle is challenged by the intricate organic radicals and metallic intermediates. Herein, an online coupled EPR/UV–vis/near‐IR detecting method is developed to simultaneously monitor both reactive radical species and copper complex intermediates during the reaction. Focusing on copper‐catalyzed phenol oxygenation with cumene hydroperoxide, the short‐lived alkylperoxyl radical (EPR signal at g = 2.0143) as well as the unexpected square planar Cu(II)‐alkoxyl radical complex (near‐IR signal at 833 nm) are unveiled during the reaction, in addition to the observable phenoxyl radical in EPR, quinone product in UV–vis, and Cu(II) center in EPR. With a comprehensive picture of diverse intermediates evolving over the same timeline, a novel Cu(I)/Cu(II) proposed relay‐catalyzed sequential radical pathway. In this sequence, Cu(II) activates hydroperoxide through Cu(II)‐OOR into the alkylperoxide radical, while the reaction between Cu(I) and hydroperoxide leads to Cu(II)(•OR)OH with high H‐atom abstracting activity. These results provide a thorough understanding of the Cu(I)/Cu(II) relay catalysis for phenol oxygenation, setting the stage for mechanistic investigations into intricate radical reactions promoted by metallic complexes.
A Novel Drug Candidate for Sepsis Targeting Heparanase by Inhibiting Cytokine Storm
Authors: Wang Danyang , Wang Kaixuan , Liu Qiutong , Liu Mingyang , Zhang Guoqiang , Feng Ke , Wang Kun , Ding Xianwei , Zhu Haomiao , Yang Song , Liu Yonghui , Li Tiehai , Gong Peng , Wang Manli , Wang Peng George , Jin Hongzhen , Zhao Wei , Yu Fan 
Published: May 2024

AbstractSepsis is an infection‐triggered, rapidly progressive systemic inflammatory syndrome with a high mortality rate. Currently, there are no promising therapeutic strategies for managing this disease in the clinic. Heparanase plays a crucial role in the pathology of sepsis, and its inhibition can significantly relieve related symptoms. Here, a novel heparanase inhibitor CV122 is rationally designed and synthesized, and its therapeutic potential for sepsis with Lipopolysaccharide (LPS) and Cecal Ligation and Puncture (CLP)‐induced sepsis mouse models are evaluated. It is found that CV122 potently inhibits heparanase activity in vitro, protects cell surface glycocalyx structure, and reduces the expression of adhesion molecules. In vivo, CV122 significantly reduces the systemic levels of proinflammatory cytokines, prevents organ damage, improves vitality, and efficiently protects mice from sepsis‐induced death. Mechanistically, CV122 inhibits the activity of heparanase, reduces its expression in the lungs, and protects glycocalyx structure of lung tissue. It is also found that CV122 provides effective protection from organ damage and death caused by Crimean‐Congo hemorrhagic fever virus (CCHFV) infection. These results suggest that CV122 is a potential drug candidate for sepsis therapy targeting heparanase by inhibiting cytokine storm.
Periodic Adjacent Pd‐Fe Pair Sites for Enhanced Nitrate Electroreduction to Ammonia via Accelerating Proton Relay
Authors: Xie Meng , Zhu Guihua , Yang Haoyu , Liu Bin , Li Minghao , Qi Chunhong , Wang Lianjun , Jiang Wan , Qiu Pengpeng , Luo Wei 
Published: May 2024

AbstractRecently, bimetallic nanoparticles (NPs) are promising for driving nitrate (NO3
−) reduction reaction (NO3RR) to produce ammonia (NH3) due to their multiple active sites and electron redistribution via strong metal–metal interaction. However, the quantitatively determining the atomic configuration of the active sites and revealing their respective roles in NO3RR process are still challenged. Herein, the configuration of atomically ordered PdFe3 L12 intermetallic NPs into mesoporous carbon nanofibers (O‐PdFe3‐mCNFs) is reported as an efficient NO3RR catalyst for NH3 synthesis. Compared to the face‐centered cubic one, the O‐PdFe3‐mCNFs demonstrate a high NO3− removal of 98.3% within 270 min with a large NH3 yield rate of 1014.2 µmol h−1 cm−2. The detailed in situ and theoretical analysis reveals that the high performance of O‐PdFe3‐mCNFs is attributed to the synergetic effect from the periodic adjacent Pd‐Fe pair sites at the ordered (110) facet via accelerating proton relay, where the Fe sites show preferable stabilization of nitrogen−oxygen (*NO) intermediates while Pd sites serve as proton reservoir for *NO hydrogenation. Moreover, the strong d‐d orbital hybridization tunes d‐band center of the alloy NPs and effectively modulates the adsorption energy of *NO3− and *NO. This synergetic electrocatalyst design offers a new avenue for developing highly efficient multifunctional NO3RR catalysts.
Daily planning conversations and AI: Keys for improving construction culture, engagement, planning, and safety
Authors: Pettinger Charles B. , Nelson Barry 
Published: May 2024

AbstractThe construction industry is known for its inherent risks, contributing to ~170,000 workplace injuries and illnesses annually in the United States. Engaging in prejob safety discussions presents a crucial chance to safeguard workers by proactively recognizing hazards and ensuring that crews are well‐oriented with safety protocols before commencing work each day. However, research shows prejob meetings are often conducted hastily without the depth required to fully uncover risks. This study examines the characteristics that distinguish high‐impact, high‐quality prejob safety conversations from lower‐ quality counterparts. Strategies are provided for improving engagement, psychological safety, hazard analysis, accountability, and leadership support to transform safety talks into dynamic interactions that empower employees to operate safely. Additionally, this study reviews leading‐edge artificial intelligence techniques, enabling construction firms to capture, analyze, and optimize their daily planning conversations at scale to drive safety excellence. Implementing the evidence‐based strategies discussed allows organizations to realize the immense potential of prejob conversations for preventing injuries and fatalities.
Intramolecular Cyclization of ‐COY (Y = OH, NHPh) to Photoredox Functionalized Benzylic C(sp3)‐H Bond. Attractive Approach to Construct γ, δ‐lactones and lactams Scaffolds
Authors: Swati Sharma Kumari , Kumar Tiwari Sandip , Pandey Ganesh 
Published: May 2024

AbstractSynthesis of γ and δ‐lactones and lactams are reported in high yield by the cyclization of −COY (Y=OH, NHPh) to the photo redox functionalized benzylic C(sp3)−H bond.
MiR‐106a targets ATG7 to inhibit autophagy and angiogenesis after myocardial infarction
Authors: Bai Guofeng , Yang Jinghao , Liao Weili , Zhou Xiaofeng , He Yingting , Li Nian , Zhang Liuhong , Wang Yifei , Dong Xiaoli , Zhang Hao , Pan Jinchun , Lai Liangxue , Yuan Xiaolong , Wang Xilong 
Published: May 2024

AbstractBackgroundMyocardial infarction (MI) is an acute condition in which the heart muscle dies due to the lack of blood supply. Previous research has suggested that autophagy and angiogenesis play vital roles in the prevention of heart failure after MI, and miR‐106a is considered to be an important regulatory factor in MI. But the specific mechanism remains unknown. In this study, using cultured venous endothelial cells and a rat model of MI, we aimed to identify the potential target genes of miR‐106a and discover the mechanisms of inhibiting autophagy and angiogenesis.MethodsWe first explored the biological functions of miR‐106a on autophagy and angiogenesis on endothelial cells. Then we identified ATG7, which was the downstream target gene of miR‐106a. The expression of miR‐106a and ATG7 was investigated in the rat model of MI.ResultsWe found that miR‐106a inhibits the proliferation, cell cycle, autophagy and angiogenesis, but promoted the apoptosis of vein endothelial cells. Moreover, ATG7 was identified as the target of miR‐106a, and ATG7 rescued the inhibition of autophagy and angiogenesis by miR‐106a. The expression of miR‐106a in the rat model of MI was decreased but the expression of ATG7 was increased in the infarction areas.ConclusionOur results indicate that miR‐106a may inhibit autophagy and angiogenesis by targeting ATG7. This mechanism may be a potential therapeutic treatment for MI.
Neuroprotective effects of resveratrol on retinal ganglion cells in glaucoma in rodents: A narrative review
Authors: Golmohammadi Maryam , Meibodi Seyed Arash Aghaei , Al‐Hawary Sulieman Ibraheem Shelash , Gupta Jitendra , Sapaev Ibrohim B. , Najm Mazin A. A. , Alwave Marim , Nazifi Mozhgan , Rahmani Mohammadreza , Zamanian Mohammad Yasin , Moriasi Gervason 
Published: May 2024

AbstractGlaucoma, an irreversible optic neuropathy, primarily affects retinal ganglion cells (RGC) and causes vision loss and blindness. The damage to RGCs in glaucoma occurs by various mechanisms, including elevated intraocular pressure, oxidative stress, inflammation, and other neurodegenerative processes. As the disease progresses, the loss of RGCs leads to vision loss. Therefore, protecting RGCs from damage and promoting their survival are important goals in managing glaucoma. In this regard, resveratrol (RES), a polyphenolic phytoalexin, exerts antioxidant effects and slows down the evolution and progression of glaucoma. The present review shows that RES plays a protective role in RGCs in cases of ischemic injury and hypoxia as well as in ErbB2 protein expression in the retina. Additionally, RES plays protective roles in RGCs by promoting cell growth, reducing apoptosis, and decreasing oxidative stress in H2O2‐exposed RGCs. RES was also found to inhibit oxidative stress damage in RGCs and suppress the activation of mitogen‐activated protein kinase signaling pathways. RES could alleviate retinal function impairment by suppressing the hypoxia‐inducible factor‐1 alpha/vascular endothelial growth factor and p38/p53 axes while stimulating the PI3K/Akt pathway. Therefore, RES might exert potential therapeutic effects for managing glaucoma by protecting RGCs from damage and promoting their survival.
Graphitisches Kohlenstoffnitrid als Photokatalysator für die decarboxylative C(sp2)−C(sp3) Kupplung mittels Nickelkatalyse
Authors: Lukas Florian , Findlay Michael T. , Fillols Méritxell , Templ Johanna , Savino Elia , Martin Benjamin , Allmendinger Simon , Furegati Markus , Noël Timothy 
Published: May 2024

AbstractDie Entwicklung robuster und zuverlässiger Methoden für den Aufbau von C(sp2)−C(sp3)‐Bindungen ist entscheidend, um eine Vielzahl strukturell diverser Substanzen in der Wirkstoffforschung und ‐entwicklung zugänglich zu machen. Obwohl bedeutende Fortschritte auf diesem Gebiet durch den Einsatz der Metallaphotoredox‐Chemie erzielt wurden, nutzen viele dieser Methoden nach wie vor Photokatalysatoren auf Edelmetallbasis aufgrund ihrer effizienten Redoxprozesse und gut anpassbaren Eigenschaften. Aufgrund der hohen Kosten, Ressourcenknappheit und oftmals erheblichen Toxizität dieser Metalle, ist es von großem Interesse, die Suche nach geeigneten Ersatz voranzutreiben. In dieser Publikation zeigen wir den Einsatz des kommerziell erhältlichen, heterogenen Halbleiters graphitisches Kohlenstoffnitrid (gCN) als Photokatalysator in Kombination mit Nickelkatalyse für die Kreuzkupplung von Arylhalogenid‐ und Carbonsäure‐Derivaten. Wie in vorherigen Berichten gezeigt, kann gCN effektiv an Einelektronenübertragungen (SET) und Energietransfer‐(EnT) Prozessen zur Bildung von C−X‐Bindungen teilnehmen. Dieses Manuskript beinhaltet neue Strategien, um die bislang auf C−O Bindungsknüpfung beschränkten Methoden mittels carbonsäurehaltigen Bausteinen um C−C Bindungsknüpfungen zu erweitern. Es wird gezeigt, dass eine Vielzahl an Arylhalogeniden als auch Carbonsäuren für diese Transformation genutzt werden kann. Im Weiteren wird das Recycling des Photokatalysators demonstriert und der Mechanismus der Reaktion untersucht.
Designing A–D–A Type Fused‐Ring Electron Acceptors with a Bulky 3D Substituent at the Central Donor Core to Minimize Non‐Radiative Losses and Enhance Organic Solar Cell Efficiency
Authors: Lu Hao , Li Dawei , Liu Wenlong , Ran Guangliu , Wu Hongbo , Wei Nan , Tang Zheng , Liu Yahui , Zhang Wenkai , Bo Zhishan 
Published: May 2024

AbstractDesigning and synthesizing narrow band gap acceptors that exhibit high photoluminescence quantum yield (PLQY) and strong crystallinity is a highly effective, yet challenging, approach to reducing non‐radiative energy losses (▵Enr) and boosting the performance of organic solar cells (OSCs). We have successfully designed and synthesized an A–D–A type fused‐ring electron acceptor, named DM‐F, which features a planar molecular backbone adorned with bulky three‐dimensional camphane side groups at its central core. These bulky substituents effectively hinder the formation of H‐aggregates of the acceptors, promoting the formation of more J‐aggregates and notably elevating the PLQY of the acceptor in the film. As anticipated, DM‐F showcases pronounced near‐infrared absorption coupled with impressive crystallinity. Organic solar cells (OSCs) leveraging DM‐F exhibit a high EQEEL value and remarkably low ▵Enr of 0.14 eV‐currently the most minimal reported value for OSCs. Moreover, the power conversion efficiency (PCE) of binary and ternary OSCs utilizing DM‐F has reached 16.16 % and 20.09 %, respectively, marking a new apex in reported efficiency within the OSCs field. In conclusion, our study reveals that designing narrow band gap acceptors with high PLQY is an effective way to reduce ▵Enr and improve the PCE of OSCs.
Harnessing Ion‐Dipole Interactions for Water‐Lean Solvation Chemistry: Achieving High‐Stability Zn Anodes in Aqueous Zinc‐Ion Batteries
Authors: Wu Mingqiang , Sun Yilun , Yang Zimin , Deng Siting , Tong Hao , Nie Xinbin , Su Yifan , Li Jianwei , Chai Guoliang 
Published: May 2024

AbstractThe reversibility and stability of aqueous zinc‐ion batteries (AZIBs) are largely limited by water‐induced interfacial parasitic reactions. Here, dimethyl(3,3‐difluoro‐2‐oxoheptyl)phosphonate (DP) is introduced to tailor primary solvation sheath and inner‐Helmholtz configurations for robust zinc anode. Informed by theoretical guidance on solvation process, DP with high permanent dipole moments can effectively substitute the coordination of H2O with charge carriers through relatively strong ion‐dipolar interactions, resulting in a water‐lean environment of solvated Zn2+. Thus, interfacial side reactions can be suppressed through a shielding effect. Meanwhile, lone‐pair electrons of oxygen and fluorinated features of DP also reinforce the interfacial affinity of metallic zinc, associated with exclusion of neighboring water to facilitate reversible zinc planarized deposition. Thus, these merits endow the Zn anode with a high‐stability performance exceeds 3800 hours at 0.5 mA cm−2 and 0.5 mAh cm−2 for Zn||Zn batteries and a high average Coulombic efficiency of 99.8 % at 4 mA cm−2 and 1 mAh cm−2 for Zn||Cu batteries. Benefiting from the stable zinc anode, the Zn||NH4V4O10 cell maintains 80.3 % of initial discharge capacity after 3000 cycles at 5 A g−1 and exhibits a high retention rate of 99.4 % against to the initial capacity during the self‐discharge characterizations.
Effect of silicon dioxide nanoparticles on the rheology properties of fresh and mechanically degraded hydrolyzed polyacrylamide polymer solutions
Authors: Mora Andrea V. , Hutin Anthony , Avendano Jorge , Carvalho Marcio S. 
Published: May 2024

AbstractPartially hydrolyzed polyacrylamide is extensively utilized in enhanced oil recovery operations. However, its efficacy is compromised by mechanical degradation during transport through injection lines, valves, and reservoir, which leads to a reduction in the average molecular weight, diminishing the solution's viscosity and viscoelastic properties, critical for efficient oil displacement. In this investigation, we characterized the degree of mechanical degradation in HPAM solutions by evaluating shear and extensional rheological parameters preand post‐degradation. Mechanical degradation was induced by subjecting them to controlled flow through a valve featuring varying degrees of constriction and flow rates. Our results demonstrate a significant reduction in zero‐shear viscosity and high‐strain extensional viscosity of mechanically degraded solutions, with reductions of up to 64%. To mitigate this issue, we explored the incorporation of silica nanoparticles as a potential remedy for mechanical degradation. These nanoparticles strengthen the network structure of HPAM, thereby reducing its susceptibility to mechanical degradation. Our findings reveal that shear and extensional viscosities of mechanically degraded NPs‐HPAM solutions experienced only minimal reductions, dropping to 12% and 0%, respectively. This underscores the effectiveness of the nanoparticle‐enhanced HPAM solutions in preserving viscosity and viscoelasticity under mechanical stress, presenting a promising avenue for improving the robustness of EOR processes.
Chemical transformations during mechanoactivation of ε‐polylysine‐poly‐L‐lactic acid mixture to obtain amphiphilic copolymers
Authors: Khaptakhanova Polina , Uspenskii Sergey , Aleksandrov Aleksey , Ryzhykau Yury , Okhrimenko Ivan 
Published: May 2024

AbstractIn this study presents a new strategy for the preparation of amphiphilic copolymers of ε‐polylysine (PL) and poly‐L‐lactic acid (PLA) using one‐step pulsed mechanochemical approach. Correlation between the synthesis parameters (ratio of homopolymers) and the structure of the resulting copolymers has been studied. The interaction products were characterized by nuclear magnetic resonance, Infrared spectroscopy, size‐exclusion chromatography, by varying the mass ratio of the initial homopolymers (PL:PLA = 10:90; 50:50; 90:10). It is shown that the largest number of product yield is formed in a ratio of homopolymers of 50:50, according to the reaction of aminolysis of polyesters. The dynamic light scattering method, transmission electron microscopy, and small‐angle x‐ray scattering were used to characterize nanoscale structures of copolymer macromolecules in aqueous solvent. As a result of pulsed mechanochemical action at all three ratios of homopolymers (PL:PLA = 10:90; 50:50; 90:10 w/w), the aminolysis reaction of the ester group occurs and branched macromolecules of copolymers are formed, which consist of chemically related sequences of homopolymers—main chain—PL, side branches—PLA. However, the maximum yield of the amphiphilic copolymer was 90 wt% with a PL:PLA ratio of 50:50. This study can serve as the development of important areas: deepen knowledge in the field of mechanochemical synthesis of amphiphilic copolymers.