bluuebunny/crossref_metadata_2025_split huggingface dataset:
Echinococcus multilocularis infection affects risk-taking behaviour in Microtus arvalis: adaptive manipulation?
Authors: Martini Matilde , Cioli Teila , Romig Thomas , Gagliardo Anna , Giunchi Dimitri , Zaccaroni Marco , Massolo Alessandro 
Published: May 2024

AbstractManipulation of host behaviour by parasites to enhance transmission to the next host is a fascinating phenomenon that has interested scientists since the 1970s. It has been proposed that infection with the cestode Echinococcus multilocularis produces an impairment of the antipredatory behaviour in the rodent intermediate host common vole, Microtus arvalis, which may facilitate transmission of the tapeworm to the canid final host. In this study, we observed the behaviour of infected common voles at 12 weeks post-infection, when protoscoleces production and maturation commonly occurs, in order to assess behavioural changes compared to uninfected controls, that might ease predation in the wild. Infected and uninfected voles were monitored for 24 h to observe their spontaneous activity. In addition, the next day, both infected and uninfected voles were subjected to 4 different behavioural tests: open field test, barrier test, platform test and air-puff test in a running wheel. No significant difference between uninfected and infected voles emerged during the behavioural tests. However, observation of spontaneous activity revealed that infected voles increased their feeding frequency and spent significantly more time above bedding even when not eating, compared to the uninfected controls. In the wild, these behavioural changes increase the animals exposure to predators, raising their chance of becoming prey. These findings are the first direct evidence consistent with behavioural manipulation by E. multilocularis on common voles.
Coherence and comprehensibility in second language speakers’ academic speaking performance
Authors: Tsunemoto Aki , Trofimovich Pavel 
Published: May 2024

AbstractThis study examined the role of discourse organization in second language (L2) comprehensibility ratings. Twelve English for Academic Purposes teachers listened to 60 L2 speech samples elicited through a TOEFL–type integrated speaking task, evaluating each sample for comprehensibility and coherence (perceived interconnectedness of ideas). The samples were analyzed for the occurrence of discourse features at micro and macro levels. Results revealed a strong association between coherence and comprehensibility (r= .70). Whereas L2 speakers’ use of additive connectives (e.g.,and) uniquely predicted comprehensibility, ordering of ideas and source–speech similarity in speakers’ performances predicted coherence. Lexical overlaps predicted both constructs. Findings underscore the importance of coherence to comprehensible academic L2 speech demonstrating that the two constructs include partially overlapping yet distinct characteristics.
Neuropsychological tests associated with symptomatic HIV-associated neurocognitive disorder (HAND) in a cohort of older adults in Tanzania
Authors: Fotheringham Lachlan , Lawson Rachael A. , Urasa Sarah , Boshe Judith , Mukaetova-Ladinska Elizabeta B. , Rogathi Jane , Howlett William , Dekker Marieke C.J. , Gray William K. , Evans Jonathan , Walker Richard W. , Makupa Philip C. , Paddick Stella-Maria 
Published: May 2024

AbstractObjective:Human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND) prevalence is expected to increase in East Africa as treatment coverage increases, survival improves, and this population ages. This study aimed to better understand the current cognitive phenotype of this newly emergent population of older combination antiretroviral therapy (cART)-treated people living with HIV (PLWH), in which current screening measures lack accuracy. This will facilitate the refinement of HAND cognitive screening tools for this setting.Method:This is a secondary analysis of 253 PLWH aged ≥50 years receiving standard government HIV clinic follow-up in Kilimanjaro, Tanzania. They were evaluated with a detailed locally normed low-literacy neuropsychological battery annually on three occasions and a consensus panel diagnosis of HAND by Frascati criteria based on clinical evaluation and collateral history.Results:Tests of verbal learning and memory, categorical verbal fluency, visual memory, and visuoconstruction had an area under the receiver operating characteristic curve >0.7 for symptomatic HAND (s-HAND) (0.70–0.72; p < 0.001 for all tests). Tests of visual memory, verbal learning with delayed recall and recognition memory, psychomotor speed, language comprehension, and categorical verbal fluency were independently associated with s-HAND in a logistic mixed effects model (p < 0.01 for all). Neuropsychological impairments varied by educational background.Conclusions:A broad range of cognitive domains are affected in older, well-controlled, East African PLWH, including those not captured in widely used screening measures. It is possible that educational background affects the observed cognitive impairments in this setting. Future screening measures for similar populations should consider assessment of visual memory, verbal learning, language comprehension, and executive and motor function.
From speculative to real: community attitudes towards government COVID-19 vaccine mandates in Western Australia from May 2021 to April 2022
Authors: Attwell Katie , Roberts Leah , Rizzi Marco 
Published: May 2024

AbstractMany governments employed mandates for COVID-19 vaccines, imposing consequences upon unvaccinated people. Attitudes towards these policies have generally been positive, but little is known about how discourses around them changed as the characteristics of the disease and the vaccinations evolved. Western Australia (WA) employed sweeping COVID-19 vaccine mandates for employment and public spaces whilst the state was closed off from the rest of the country and world, and mostly with no COVID-19 in the community. This article analyses WA public attitudes during the mandate policy lifecycle from speculative to real. Qualitative interview data from 151 adults were analysed in NVivo 20 via a novel chronological analysis anchored in key policy phases: no vaccine mandates, key worker vaccine mandates, vaccine mandates covering 75% of the workforce and public space mandates. Participants justified mandates as essential for border reopening and, less frequently, for goals such as protecting the health system. However, public discourse focusing on ‘getting coverage rates up’ may prove counter-productive for building support for vaccination; governments should reinforce end goals in public messaging (reducing suffering and saving lives) because such messaging is likely to be more meaningful to vaccination behaviour in the longer term.
Optional but not qualified: Neutrality, the UN Charter and humanitarian objectives
Authors: Schmid Evelyne 
Published: May 2024

AbstractNeutral States must abstain from supporting a party to a conflict with military equipment and assistance. This core aspect of the law of neutrality has not changed with the adoption of the UN Charter in 1945, or with the brutal Russian aggression against Ukraine. That said, by reviewing the changes to neutrality law over time, this article finds plausible reasons to believe that neutrality has – for better or worse – become optional for the vast majority of States, which can today opt to be non-belligerent States – i.e., States that are neither neutral nor parties to the armed conflict. All States have to cooperate to bring to an end serious violations of international law, including humanitarian law, and this duty of cooperation has abolished “sitting-still neutrality”, but it does not render neutrality law moot. This reading of “optional but not qualified” neutrality maintains the core neutrality idea of abstaining in military matters. In this article, I argue that views of “obsolete” or “qualified” neutrality are not new at all but depart from well-accepted rules of legal interpretation and raise concerns about double standards. Viewing neutrality as optional but unqualifiable offers greater conceptual clarity, is more honest than alternative views, and comes with advantages for humanitarian action.
Sphalerite Records Cd Isotopic Signatures of the Parent Rocks in Hydrothermal Systems: A Case Study From the Nayongzhi Zn–Pb Deposit, Southwest China
Authors: Song Wenrui , Zhu Chuanwei , Wen Hanjie , Huang Zhilong , Wei Chen , Zhang Yuxu , Zhou Zhengbing , Yang Zhen , Chen Xiaocui , Luais Béatrice , Cloquet Christophe 
Published: May 2024

AbstractMetal stable isotopes (e.g., Zn, Cd, and Cu) have been used to track metal sources in different types of hydrothermal systems. However, metal isotopic variations in sulphides could be triggered by various factors such as mineral precipitation and fluid mixing. Thus, tracking the metal sources of hydrothermal systems is still a big challenge for metal isotopes. In this study, we investigated the Cd isotopic systematics of sphalerite from the Nayongzhi Zn–Pb deposit, which is a Mississippi Valley‐type (MVT) deposit in the Sichuan–Yunnan–Guizhou mineralization province (SYGMP). We reinterpreted the published S isotope data for the SYGMP and found that the large S isotopic variations were controlled by Rayleigh fractionation between sulphide and reduced S. As such, a model that involves mixing of a metal‐rich fluid with a reduced S pool formed by thermochemical sulfate reduction (TSR) can explain the ore formation in the Nayongzhi deposit. Based on this model, no Cd isotopic fractionation was observed due to its low solubility in fluids during mixing, and thus the Cd isotopic variations of sphalerite were inherited from the source rocks. The large range of Zn/Cd ratios and uniform Cd isotopic compositions of the sulphides are similar to those of igneous rocks but different from those of sedimentary rocks, indicating that Zn and Cd were derived mainly from basement rocks (e.g., migmatite, gneiss, and granulite). Our results reaffirm that metal stable isotopes, particularly Cd isotope compositions of sphalerite, are powerful geochemical tracers for investigating the formation mechanisms of ore deposits.
Planetary Paleomagnetic Intensity Recording Fidelity Test Using a Synthetic Lava
Authors: Wen Chen , Wang Huapei , Chou Yu‐Min , Wang Chun‐Chieh , Chen Xiaowei , Han Fei , Miao Junxiang , Ma Yiming , Liu Jiabo , Karson Jeffrey A. 
Published: May 2024

AbstractMeteorite paleomagnetism is fundamental to understanding planetary dynamo processes and the evolution of the early Solar System. However, due to the extraterrestrial and ancient origins of meteorites, their paleomagnetic recording fidelity remains uncertain, which can be tested from a planetary sample formed in a known field. On Earth, historic lavas are used to examine paleomagnetic recording fidelity through the Thellier‐series experiment and other paleointensity methods, which can produce paleointensity estimates to test against the known field strength. But natural terrestrial rocks have different magnetic mineralogy from planetary samples, so they cannot faithfully infer the recording fidelity of meteorites. Here, we used an iron‐particle‐bearing sample from the Syracuse University Lava Project (SULP), which is analogous to the lunar basalts and howardite‐eucrite‐diogenite meteorites and forms in the present‐day Earth's field, to investigate the recording fidelity of these meteorites. No remanence has been identified in the high coercivity range with alternating field (AF) demagnetization due to the sample's low coercivity and AF noise, which produces underestimated paleointensities. Two accurate thermal paleointensities indicate that we may acquire accurate paleointensities from non‐ideal multidomain (MD) iron grains with the Thellier‐Coe and RESET methods, but the success rate is low due to the MD effect and thermal alteration in the experiments. Our results imply that MD iron‐bearing meteorites have the potential to provide accurate paleointensities that can be used to constrain planetary processes.
A Scaling Relation for Core Heating by Giant Impacts and Implications for Dynamo Onset
Authors: Zhou You , Driscoll Peter E. , Zhang Mingming , Reinhardt Christian , Meier Thomas 
Published: May 2024

AbstractAccretional heating of Earth's interior during formation is pivotal to its subsequent thermal and chemical evolution. In particular, impact heating of Earth's core is expected, but its amplitude and radial distribution within the core is unknown and could influence the onset of the geodynamo. The uncertainty is due, in part, to the lack of constraints on the temperature of the interior following formation due to the difficulty of preserving a record of such a high energy environment, and the assertion that super‐heating during formation would be rapidly lost through magma ocean cooling. Here we systematically investigate core heating due to giant impacts using a Smoothed Particle Hydrodynamics (SPH) code with simulations spanning a range of impact angles, velocities, and masses. From these simulations we derive a scaling relation for core heating that depends on the impact parameters and predicts the radial core temperature profile following the impact. Our findings show that a significant amount of heat is deposited into the core, with a canonical impact scenario resulting in an average core temperature increase of about 3000 K, approximately 500 K higher than that of the overlying mantle. In this case the heat distribution within the core produces a strong thermal stratification. We use a parameterized cooling model to estimate that the core could have cooled to an adiabatic state ∼290 Myr after a canonical impact, which is consistent with the observed time span between the age of the Moon and evidence for an active geodynamo.
Predicting iatrogenic adrenal insufficiency in neonates exposed to prolonged steroid courses: do cortisol levels help?
Authors: Rosano Kristen , Bery Saya , Marasch Jaime , Farrell Ryan , Mastrandrea Lucy D. , Ryan Rita M. 
Published: May 2024

Abstract
Objective
To determine whether random cortisol levels obtained in neonates to assess for secondary adrenal insufficiency (AI) after prolonged steroid exposure are predictive of central AI.

Study design
Data were collected on neonates born 2017–2022 who received ≥10 consecutive days of systemic steroids and had cortisol measured thereafter. Data were then collected on whether those neonates developed signs of AI or had a failed adrenocorticotropic hormone (ACTH) stimulation test.

Results
Of the 71 cortisol levels (in 67 neonates) that were analyzed, there was no difference in cortisol levels between neonates who developed AI (median cortisol level of 6.5 mcg/dl) and those who did not (median of 9.2 mcg/dl), or between those who failed their ACTH stimulation test or passed it, using Wilcoxon ranked sum tests.

Conclusion
These findings demonstrate that cortisol levels may not be helpful in identifying AI in neonates exposed to prolonged steroids.
Measurement of diamine oxidase (DAO) during low-histamine or ordinary diet in patients with histamine intolerance
Authors: Rentzos Georgios , Weisheit Adina , Ekerljung Linda , van Odijk Jenny 
Published: May 2024

Abstract
Background/Objectives
Quantification of diamine oxidase (DAO) concentrations in serum has been proposed as an adjunctive diagnostic modality for the evaluation of histamine intolerance (HIT). Limited empirical data exist concerning the influence of dietary patterns on DAO levels.

Subjects/Methods
In the context of a prospective study employing a crossover design, 18 individuals diagnosed with HIT were randomized to initiate either a low histamine diet (LHD) or a conventional mixed diet (MXD). Serum DAO concentrations were measured at the commencement of the study and following each dietary phase. A control group underwent analogous DAO assessments without imposition of dietary constraints.

Results
During the time when a diet restricted in histamine was implemented, noticeable differences in changes in DAO levels did not become apparent when compared to the changes observed during the mixed (MXD) phase. Specifically, among the group, 10 of the 18 patients exhibited elevated DAO values subsequent to the LHD regimen, while the remaining eight displayed either reduced or unchanging DAO levels. The prevalence of elevated DAO levels in the LHD group did not differ significantly from that observed in the control group during the MXD phase. Additionally, during the LHD phase, patients reported a significant reduction in gastrointestinal and cutaneous symptoms.

Conclusions
This prospective investigation underscores the enduring utility of a histamine-restricted diet, coupled with structured dietary reintroduction, as an efficacious diagnostic approach for individuals presenting with suspected food-related histamine hypersensitivity. Notably, the measurement of DAO levels appears to furnish only a limited capacity to discern dietary-induced fluctuations. Notwithstanding, the dynamics of DAO alteration do not appear to exhibit a discernible association with specific dietary patterns, a finding consistent across both patient and control groups.
Preoperative blood urea nitrogen-to-serum albumin ratio for prediction of in-hospital mortality in patients who underwent emergency surgery for acute type A aortic dissection
Authors: Wu Qingsong , Zheng Jian , Lin Jianling , Xie Linfeng , Tang Mirong , Ke Meng , Chen Liangwan 
Published: May 2024

AbstractThe study aimed to assess the predictive value of blood urea nitrogen (BUN)-to-albumin ratio (BA-R) for in-hospital mortality in patients undergoing emergency surgery for acute type A aortic dissection (ATAAD). Patients who were diagnosed with ATAAD and underwent emergency surgery within 48 hours of onset at our hospital between January 2015 and December 2021 were included in this study. The primary endpoint of this study was postoperative in-hospital mortality (POIM). The data of the survivors and non-survivors were retrospectively compared analyses. A total of 557 ATAAD patients were included, with 505 survivors and 52 non-survivors. The preoperative BA-R of the non-survivor group was significantly higher than that of the survivor group (P < 0.001). Univariate regression analysis showed that preoperative BA-R, serum creatinine level, SA level, D-dimer level, age, myocardial ischemia, cerebral ischemia, and aortic clamp time were risk factors for POIM. In addition, multivariable regression analysis showed that preoperative BA-R ≥ 0.155 mmol/g was a risk factor for POIM (odds ratio, 6.815 [3.582–12.964]; P < 0.001). Receiver operating characteristic curve indicated that the cut-off point for preoperative BA-R was ≥0.155 mmol/g (area under the curve =0.874). The sensitivity and specificity of preoperative BA-R in predicting the POIM of patients who underwent emergency surgery for ATAAD were 84.6% and 71.3%, respectively (95% confidence interval, 0.829–0.919; P < 0.001). In conclusion, Preoperative BA-R is a simple, rapid, and potentially useful prognostic indicator of POIM in patients with ATAAD.
Development of a long noncoding RNA-based machine learning model to predict COVID-19 in-hospital mortality
Authors: Devaux Yvan , Zhang Lu , Lumley Andrew I. , Karaduzovic-Hadziabdic Kanita , Mooser Vincent , Rousseau Simon , Shoaib Muhammad , Satagopam Venkata , Adilovic Muhamed , Srivastava Prashant Kumar , Emanueli Costanza , Martelli Fabio , Greco Simona , Badimon Lina , Padro Teresa , Lustrek Mitja , Scholz Markus , Rosolowski Maciej , Jordan Marko , Brandenburger Timo , Benczik Bettina , Agg Bence , Ferdinandy Peter , Vehreschild Jörg Janne , Lorenz-Depiereux Bettina , Dörr Marcus , Witzke Oliver , Sanchez Gabriel , Kul Seval , Baker Andy H. , Fagherazzi Guy , Ollert Markus , Wereski Ryan , Mills Nicholas L. , Firat Hüseyin 
Published: May 2024

AbstractTools for predicting COVID-19 outcomes enable personalized healthcare, potentially easing the disease burden. This collaborative study by 15 institutions across Europe aimed to develop a machine learning model for predicting the risk of in-hospital mortality post-SARS-CoV-2 infection. Blood samples and clinical data from 1286 COVID-19 patients collected from 2020 to 2023 across four cohorts in Europe and Canada were analyzed, with 2906 long non-coding RNAs profiled using targeted sequencing. From a discovery cohort combining three European cohorts and 804 patients, age and the long non-coding RNA LEF1-AS1 were identified as predictive features, yielding an AUC of 0.83 (95% CI 0.82–0.84) and a balanced accuracy of 0.78 (95% CI 0.77–0.79) with a feedforward neural network classifier. Validation in an independent Canadian cohort of 482 patients showed consistent performance. Cox regression analysis indicated that higher levels of LEF1-AS1 correlated with reduced mortality risk (age-adjusted hazard ratio 0.54, 95% CI 0.40–0.74). Quantitative PCR validated LEF1-AS1’s adaptability to be measured in hospital settings. Here, we demonstrate a promising predictive model for enhancing COVID-19 patient management.
Revealing trends and persistent cycles of non-autonomous systems with autonomous operator-theoretic techniques
Authors: Froyland Gary , Giannakis Dimitrios , Luna Edoardo , Slawinska Joanna 
Published: May 2024

AbstractAn important problem in modern applied science is to characterize the behavior of systems with complex internal dynamics subjected to external forcings. Many existing approaches rely on ensembles to generate information from the external forcings, making them unsuitable to study natural systems where only a single realization is observed. A prominent example is climate dynamics, where an objective identification of signals in the observational record attributable to natural variability and climate change is crucial for making climate projections for the coming decades. Here, we show that operator-theoretic techniques previously developed to identify slowly decorrelating observables of autonomous dynamical systems provide a powerful means for identifying nonlinear trends and persistent cycles of non-autonomous systems using data from a single trajectory of the system. We apply our framework to real-world examples from climate dynamics: Variability of sea surface temperature over the industrial era and the mid-Pleistocene transition of Quaternary glaciation cycles.
Fatal COVID-19 pulmonary disease involves ferroptosis
Authors: Qiu Baiyu , Zandkarimi Fereshteh , Saqi Anjali , Castagna Candace , Tan Hui , Sekulic Miroslav , Miorin Lisa , Hibshoosh Hanina , Toyokuni Shinya , Uchida Koji , Stockwell Brent R. 
Published: May 2024

AbstractSARS-CoV-2 infection causes severe pulmonary manifestations, with poorly understood mechanisms and limited treatment options. Hyperferritinemia and disrupted lung iron homeostasis in COVID-19 patients imply that ferroptosis, an iron-dependent cell death, may occur. Immunostaining and lipidomic analysis in COVID-19 lung autopsies reveal increases in ferroptosis markers, including transferrin receptor 1 and malondialdehyde accumulation in fatal cases. COVID-19 lungs display dysregulation of lipids involved in metabolism and ferroptosis. We find increased ferritin light chain associated with severe COVID-19 lung pathology. Iron overload promotes ferroptosis in both primary cells and cancerous lung epithelial cells. In addition, ferroptosis markers strongly correlate with lung injury severity in a COVID-19 lung disease model using male Syrian hamsters. These results reveal a role for ferroptosis in COVID-19 pulmonary disease; pharmacological ferroptosis inhibition may serve as an adjuvant therapy to prevent lung damage during SARS-CoV-2 infection.