bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extracellular matrix stiffness and tumor-associated macrophage polarization: new fields affecting immune exclusion
Authors: Yu Ke-Xun , Yuan Wei-Jie , Wang Hui-Zhen , Li Yong-Xiang 
Published: May 2024

AbstractIn the malignant progression of tumors, there is deposition and cross-linking of collagen, as well as an increase in hyaluronic acid content, which can lead to an increase in extracellular matrix stiffness. Recent research evidence have shown that the extracellular matrix plays an important role in angiogenesis, cell proliferation, migration, immunosuppression, apoptosis, metabolism, and resistance to chemotherapeutic by the alterations toward both secretion and degradation. The clinical importance of tumor-associated macrophage is increasingly recognized, and macrophage polarization plays a central role in a series of tumor immune processes through internal signal cascade, thus regulating tumor progression. Immunotherapy has gradually become a reliable potential treatment strategy for conventional chemotherapy resistance and advanced cancer patients, but the presence of immune exclusion has become a major obstacle to treatment effectiveness, and the reasons for their resistance to these approaches remain uncertain. Currently, there is a lack of exact mechanism on the regulation of extracellular matrix stiffness and tumor-associated macrophage polarization on immune exclusion. An in-depth understanding of the relationship between extracellular matrix stiffness, tumor-associated macrophage polarization, and immune exclusion will help reveal new therapeutic targets and guide the development of clinical treatment methods for advanced cancer patients. This review summarized the different pathways and potential molecular mechanisms of extracellular matrix stiffness and tumor-associated macrophage polarization involved in immune exclusion and provided available strategies to address immune exclusion.
Characterisation of premature cell senescence in Alzheimer’s disease using single nuclear transcriptomics
Authors: Fancy Nurun N. , Smith Amy M. , Caramello Alessia , Tsartsalis Stergios , Davey Karen , Muirhead Robert C. J. , McGarry Aisling , Jenkyns Marion H. , Schneegans Eleonore , Chau Vicky , Thomas Michael , Boulger Sam , Cheung To Ka Dorcas , Adair Emily , Papageorgopoulou Marianna , Willumsen Nanet , Khozoie Combiz , Gomez-Nicola Diego , Jackson Johanna S. , Matthews Paul M. 
Published: May 2024

AbstractAging is associated with cell senescence and is the major risk factor for AD. We characterized premature cell senescence in postmortem brains from non-diseased controls (NDC) and donors with Alzheimer’s disease (AD) using imaging mass cytometry (IMC) and single nuclear RNA (snRNA) sequencing (> 200,000 nuclei). We found increases in numbers of glia immunostaining for galactosidase beta (> fourfold) and p16INK4A (up to twofold) with AD relative to NDC. Increased glial expression of genes related to senescence was associated with greater β-amyloid load. Prematurely senescent microglia downregulated phagocytic pathways suggesting reduced capacity for β-amyloid clearance. Gene set enrichment and pseudo-time trajectories described extensive DNA double-strand breaks (DSBs), mitochondrial dysfunction and ER stress associated with increased β-amyloid leading to premature senescence in microglia. We replicated these observations with independent AD snRNA-seq datasets. Our results describe a burden of senescent glia with AD that is sufficiently high to contribute to disease progression. These findings support the hypothesis that microglia are a primary target for senolytic treatments in AD.
The role of vitamins and nutrients in rosacea
Authors: Algarin Yanci A. , Pulumati Anika , Jaalouk Dana , Tan Jiali , Nouri Keyvan 
Published: May 2024

AbstractRosacea is a common inflammatory skin condition displaying symptoms like flushing, erythema, papules, and pustules. Oral antibiotics, despite long-term adverse effects, are often used due to topical treatment limitations, underscoring the need for cost-effective choices like dietary modifications. Our review investigates the role of vitamins and minerals in rosacea, and provides evidence-based recommendations for supplementation and topical treatment of these nutrients for rosacea. An online search was performed on PubMed, Web of Science, Science Direct, Google Scholar, and ClinicalTrials.gov from 1998 to 2023. Included studies were summarized and assessed for quality and relevance in rosacea management. Varied outcomes emerged concerning the impact of essential vitamins and minerals on rosacea treatment. Vitamin A derivatives, specifically oral isotretinoin, demonstrated significant efficacy, with a 90% reduction in lesions, complete remission in 24% of patients, and marked improvement in 57% of patients. Vitamin B3 derivatives, such as topical 1-methylnicotinamide 0.25% and NADH 1%, improved symptoms in 76.4% (26/34) and 80% of patients, respectively. Outcomes for vitamin D, vitamin C, and zinc supplementation varied across studies. However, zinc sulfate solution 5% significantly reduced acne rosacea severity for patients with 40% and 60% exhibiting a moderate or good response, respectively. Omega-3 fatty acids showed significant improvement in alleviating xerophthalmia in 64% of patients with ocular rosacea. Vitamins and minerals hold potential in managing rosacea symptoms, offering a safe and cost-effective alternative or adjunctive treatment option. Currently, there are no established recommendations regarding their supplementation for rosacea. Studies assessing serum levels of vitamins and minerals in relation to rosacea are warranted, as this avenue holds potential for future advancements in the field.
Effect of low-volume combined aerobic and resistance high-intensity interval training on vascular health in people with type 2 diabetes: a randomised controlled trial
Authors: Cox Emily R. , Gajanand Trishan , Keating Shelley E. , Hordern Matthew D. , Burton Nicola W. , Green Daniel J. , Ramos Joyce S. , Ramos Maximiano V. , Fassett Robert G. , Cox Stephen V. , Coombes Jeff S. , Bailey Tom G. 
Published: May 2024

Abstract
Purpose
We compared the effects of low-volume combined aerobic and resistance high-intensity interval training (C-HIIT), combined moderate-intensity continuous training (C-MICT) and waitlist control (CON) on vascular health after 8-weeks of supervised training, and an additional 10-months of self-directed training, in adults with type 2 diabetes (T2D).

Methods
Sixty-nine low active adults with T2D were randomised to 8-weeks of supervised C-HIIT (3 times/week, 78-min/week), C-MICT (current exercise guidelines, 4 times/week, 210-min/week) or CON. CON underwent usual care for 8-weeks before being re-randomised to C-HIIT or C-MICT. This was followed by 10-months of self-directed training for participants in C-HIIT and C-MICT. Vascular outcomes were evaluated at baseline, 8-weeks, and 12-months.

Results
After 8-weeks, supervised C-HIIT significantly improved relative flow-mediated dilation (FMD) compared with CON (mean difference [MD] 0.8% [0.1, 1.4], p = 0.025). Although not significantly different from CON, the magnitude of change in relative FMD following 8-weeks of supervised C-MICT was similar (MD 0.8% [–0.1, 1.7], p = 0.080). There were no differences in haemodynamic indices, carotid-femoral pulse wave velocity (cfPWV), or aortic reservoir pressure between groups at 8-weeks. After 12-months, there was a significant reduction in haemodynamic indices (time effect, p < 0.05) for both C-HIIT and C-MICT, with no between-group difference. The reduction in cfPWV over 12-months was significantly greater in C-MICT than C-HIIT (group × time effect, p = 0.018). There was no difference in FMD over time or between groups at 12-months.

Conclusions
Short-term supervised C-HIIT and C-MICT both increased brachial artery FMD compared with CON. Long-term C-HIIT and C-MICT were beneficial for improving haemodynamic indices, but not brachial artery FMD. C-MICT was superior to C-HIIT for improving cfPWV at 12-months.
Trial Registration: Australian New Zealand Clinical Trials Registry Identifier ACTRN12615000475549.
Full robotic versus open ALPPS: a bi-institutional comparison of perioperative outcomes
Authors: Guidetti Cristiano , Müller Philip C. , Magistri Paolo , Jonas Jan Philipp , Odorizzi Roberta , Kron Philipp , Guerrini Gianpiero , Oberkofler Christian E. , Di Sandro Stefano , Clavien Pierre-Alain , Petrowsky Henrik , Di Benedetto Fabrizio 
Published: May 2024

Abstract
Background
In primarily unresectable liver tumors, ALPPS (Associating Liver Partition and Portal Vein Ligation for Staged hepatectomy) may offer curative two-stage hepatectomy trough a fast and extensive hypertrophy. However, concerns have been raised about the invasiveness of the procedure. Full robotic ALPPS has the potential to reduce the postoperative morbidity trough a less invasive access. The aim of this study was to compare the perioperative outcomes of open and full robotic ALPPS.

Methods
The bicentric study included open ALPPS cases from the University Hospital Zurich, Switzerland and robotic ALPPS cases from the University of Modena and Reggio Emilia, Italy from 01/2015 to 07/2022. Main outcomes were intraoperative parameters and overall complications.

Results
Open and full robotic ALPPS were performed in 36 and 7 cases. Robotic ALPPS was associated with less blood loss after both stages (418 ± 237 ml vs. 319 ± 197 ml; P = 0.04 and 631 ± 354 ml vs. 258 ± 53 ml; P = 0.01) as well as a higher rate of interstage discharge (86% vs. 37%; P = 0.02). OT was longer with robotic ALPPS after both stages (371 ± 70 min vs. 449 ± 81 min; P = 0.01 and 282 ± 87 min vs. 373 ± 90 min; P = 0.02). After ALPPS stage 2, there was no difference for overall complications (86% vs. 86%; P = 1.00) and major complications (43% vs. 39%; P = 0.86). The total length of hospital stay was similar (23 ± 17 days vs. 26 ± 13; P = 0.56).

Conclusion
Robotic ALPPS was safely implemented and showed potential for improved perioperative outcomes compared to open ALPPS in an experienced robotic center. The robotic approach might bring the perioperative risk profile of ALPPS closer to interventional techniques of portal vein embolization/liver venous deprivation.
The effectiveness of personalised surveillance and aftercare in breast cancer follow-up: a systematic review
Authors: van Maaren Marissa C. , van Hoeve Jolanda C. , Korevaar Joke C. , van Hezewijk Marjan , Siemerink Ester J. M. , Zeillemaker Anneke M. , Klaassen-Dekker Anneleen , van Uden Dominique J. P. , Volders José H. , Drossaert Constance H. C. , Siesling Sabine ,   on behalf of the NABOR project group, van Maaren Marissa C. , Retel Valesca P. , Knottnerus Bart , van Leeuwen-Stok Elise , Guerrero-Paez Cristina , Burgers Jako S. , Zeillemaker Anneke M. , Peeters Marie-Jeanne T. F. D. Vrancken , van Hezewijk Marjan , Siemerink Ester J. M. , Honkoop Aafke H. , Veltman Jeroen , Mann Ritse , Wiegersma Jannet , Claassen Saskia , van der Lee Marije L. , van Uden-Kraan Cornelia F. , Korevaar J. C. , van Korevaar M. , Siemerink E. , Zeillemaker A. M. , Klaassen-Dekker A. , Drossaert C. H. C. , Siesling S. C. 
Published: May 2024

Abstract
Purpose
Breast cancer follow-up (surveillance and aftercare) varies from one-size-fits-all to more personalised approaches. A systematic review was performed to get insight in existing evidence on (cost-)effectiveness of personalised follow-up.

Methods
PubMed, Scopus and Cochrane were searched between 01–01-2010 and 10–10-2022 (review registered in PROSPERO:CRD42022375770). The inclusion population comprised nonmetastatic breast cancer patients ≥ 18 years, after completing curative treatment. All intervention-control studies studying personalised surveillance and/or aftercare designed for use during the entire follow-up period were included. All review processes including risk of bias assessment were performed by two reviewers. Characteristics of included studies were described.

Results
Overall, 3708 publications were identified, 64 full-text publications were read and 16 were included for data extraction. One study evaluated personalised surveillance. Various personalised aftercare interventions and outcomes were studied. Most common elements included in personalised aftercare plans were treatment summaries (75%), follow-up guidelines (56%), lists of available supportive care resources (38%) and PROs (25%). Control conditions mostly comprised usual care. Four out of seven (57%) studies reported improvements in quality of life following personalisation. Six studies (38%) found no personalisation effect, for multiple outcomes assessed (e.g. distress, satisfaction). One (6.3%) study was judged as low, four (25%) as high risk of bias and 11 (68.8%) as with concerns.

Conclusion
The included studies varied in interventions, measurement instruments and outcomes, making it impossible to draw conclusions on the effectiveness of personalised follow-up. There is a need for a definition of both personalised surveillance and aftercare, whereafter outcomes can be measured according to uniform standards.
Low avascular necrosis rates in femoral neck fractures: efficacy of cannulated screw fixation
Authors: Scattergood S. D. , Berry A. L. , Flannery O. , Burdon A. , Mitchell S. R. , Fletcher J. W. A. 
Published: May 2024

Abstract
Purpose
Cannulated screw fixation for femoral neck fractures is often limited by concerns of avascular necrosis (AVN) occurring, historically seen in 5–40% of fixed intracapsular fractures. This study aims to assess the outcomes, particularly the AVN rate, associated with current surgical techniques within our unit.

Methods
We conducted a single-center cross-sectional study, manually searching operative records between July 14, 2014, and December 1, 2018, identifying patients with intracapsular fractured neck of femur fixed with cannulated screws, with a minimum of two years follow-up. Patient records and radiographs were reviewed for clinical and radiographic diagnoses of AVN, non-union, post-operative metalwork infection, and screw penetration of the head. Additionally, fracture pattern and displacement, screw configuration, reduction techniques, and adequacy of reduction were recorded, with radiographs independently analyzed by four orthopedic surgeons.

Results
Fifty-six patients were included; average age of 67 years (range 30–100). Forty-two patients (75%) sustained displaced fractures and 14 patients (25%) had undisplaced fractures. Two (4%) patients developed AVN, with no cases of non-union, post-operative metalwork infection or screw penetration of the head. Eight patients (14%) sustained a high-energy injury, though none of these patients developed AVN. All fractures required closed reduction; no open reductions performed. Twenty-seven (64%) of reductions were adequate.

Conclusion
Our observed AVN rate is notably lower than the widely reported figures, even among a significant proportion of displaced fractures that were fixed. This study underscores that with adequate fixation, cannulated screws represent an excellent option for treating intracapsular neck of femur fractures, even in cases of displaced fracture patterns with imperfect reduction.
A simulator-based approach for testing and assessing human supervised autonomous ship navigation
Authors: Brandsæter Andreas , Madsen Andreas 
Published: May 2024

AbstractThis paper proposes and demonstrates a simulator-based approach for testing and assessing human operators’ ability and performance in supervising autonomous ships. In the autonomy concept studied here, it is assumed that the autonomous navigation system is capable of detecting and notifying the human operator prior to entering a challenging situation. The system will attempt to resolve the situation with a proposed evasive maneuver, but the system may occasionally make errors or select sub-optimal solutions. When the human operator is notified about a challenging situation, the operator should closely assess the situation, and intervene if (and only if) necessary. The proposed approach allows us to test and quantify the human operators’ abilities and performances in supervising an autonomously navigated ship. The approach is demonstrated on 56 simulator experiments, involving seven different navigators that perform eight different traffic scenarios. The scenarios are all based on real traffic data collected from a Norwegian ferry-crossing. The demonstration shows that the candidates are successful in supervising the autonomous ship in low-complexity traffic scenarios where it is easy for the operator to interpret the system’s decisions. The operators’ ability to intervene when and only when needed does, however, decline in more complex scenarios, and their performance is highly dependent on the traffic scenario and vary significantly between the candidates.
Intervention modalities for brain fog caused by long-COVID: systematic review of the literature
Authors: Gorenshtein Alon , Liba Tom , Leibovitch Liron , Stern Shai , Stern Yael 
Published: May 2024

AbstractIndividuals suffering from long-COVID can present with “brain fog”, which is characterized by a range of cognitive impairments, such as confusion, short-term memory loss, and difficulty concentrating. To date, several potential interventions for brain fog have been considered. Notably, no systematic review has comprehensively discussed the impact of each intervention type on brain fog symptoms. We included studies on adult (aged > 18 years) individuals with proven long- COVID brain-fog symptoms from PubMed, MEDLINE, Central, Scopus, and Embase. A search limit was set for articles published between 01/2020 and 31/12/2023. We excluded studies lacking an objective assessment of brain fog symptoms and patients with preexisting neurological diseases that affected cognition before COVID-19 infection. This review provided relevant information from 17 studies. The rehabilitation studies utilized diverse approaches, leading to a range of outcomes in terms of the effectiveness of the interventions. Six studies described noninvasive brain stimulation, and all showed improvement in cognitive ability. Three studies described hyperbaric oxygen therapy, all of which showed improvements in cognitive assessment tests and brain perfusion. Two studies showed that the use of Palmitoylethanolamide and Luteolin (PEA-LUT) improved cognitive impairment. Noninvasive brain stimulation and hyperbaric oxygen therapy showed promising results in the treatment of brain fog symptoms caused by long-COVID, with improved perfusion and cortical excitability. Furthermore, both rehabilitation strategies and PEA-LUT administration have been associated with improvements in symptoms of brain fog. Future studies should explore combinations of interventions and include longer follow-up periods to assess the long-term effects of these treatments.
Inclusion body myositis, viral infections, and TDP-43: a narrative review
Authors: Văcăraş Vitalie , Vulturar Romana , Chiş Adina , Damian Laura 
Published: May 2024

AbstractThe ubiquitous RNA-processing molecule TDP-43 is involved in neuromuscular diseases such as inclusion body myositis, a late-onset acquired inflammatory myopathy. TDP-43 solubility and function are disrupted in certain viral infections. Certain viruses, high viremia, co-infections, reactivation of latent viruses, and post-acute expansion of cytotoxic T cells may all contribute to inclusion body myositis, mainly in an age-shaped immune landscape. The virally induced senescent, interferon gamma-producing cytotoxic CD8+ T cells with increased inflammatory, and cytotoxic features are involved in the occurrence of inclusion body myositis in most such cases, in a genetically predisposed host. We discuss the putative mechanisms linking inclusion body myositis, TDP-43, and viral infections untangling the links between viruses, interferon, and neuromuscular degeneration could shed a light on the pathogenesis of the inclusion body myositis and other TDP-43-related neuromuscular diseases, with possible therapeutic implications.
Avian functional diversity retained in a tropical rainforest fragment after more than 120 years of turnover
Authors: LOW Bing Wen , WEE Shelby Qi Wei , SOH Malcolm Chu Keong , ER Kenneth Boon Hwee 
Published: May 2024

AbstractDeforestation is linked to the increasing prevalence of small forest fragments worldwide and an associated loss in functional diversity. However, our long-term understanding on how biodiversity and functional roles respond in such isolated fragments is limited, especially in Southeast Asia. We compared the bird community in a small primary rainforest fragment in the Singapore Botanic Gardens, a UNESCO World Heritage Site, using historical records in 1898 and contemporary surveys conducted in 1998 and 2018–2021. Species composition was expectedly dissimilar between the 1898 and contemporary bird communities (50%), driven mostly by turnover (45.5%) rather than nestedness (4.5%). Despite the changes in community composition and species extirpations, both species richness and functional diversity were retained. Our results suggest that small forest fragments can form novel bird communities that are functionally similar to previous communities that inhabited the fragment, leading to the retention of functional diversity. Such functional redundancy may be encouraged through habitat restoration initiatives adjacent to fragmented forests.
Impact of human capital and natural resources on environmental quality in South Asia
Authors: Tariq Nazish , Ali Minhaj , Usman Muhammad 
Published: May 2024

AbstractThis study examines the importance of human capital and natural resources on environmental quality in South Asia by using panel data that ranges from 1975 to 2021. Advanced cointegration approaches establish the long-term linkages between human capital, natural resources, economic growth, economic growth squared, urban population, industrial value added, and ecological footprint. To explore the long and short-run association among these variables, this study applied the panel autoregressive distributed lags (ARDL) model. The outcome designates that human capital has a negative and significant alliance with environmental quality, whereas economic growth and economic growth square affect environmental quality positively and negatively, confirming the existence of the environmental Kuznets curve (EKC) hypothesis. Urban population growth and natural resources have significant negative associations with environmental pollution, whereas industrial value added increases the pollution levels in South Asia. Lastly, the outcome of the interaction between human capital and natural resource rent on the ecological footprint has a significant positive effect. This study recommends that South Asian nations improve their human capital to promote industrial modernization, expansion of green technology, and energy-efficient habits. Utilizing natural resources also helps South Asian nations maintain a clean ecosystem. Additionally, South Asian nations ought to vigilantly track the negative consequences of industrialization on the atmosphere. Thus, ecological sustainability requires human capital and natural resources.