bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global overview of anterior cruciate ligament reconstruction in children and adolescents over the past 20 years: a bibliometric analysis
Authors: Liang Jiamin , Luo Yuxin , Yang Yingzhen , Xie Huanyu , Huang Zirong , Zhong Mingjin , Zhu Weimin 
Published: June 2024

Abstract
Objectives
The objectives of this paper is to conduct a bibliometric analysis to examine the research status and development trend of anterior cruciate ligament injury and reconstruction in children and adolescents over the past 20 years.

Design
Descriptive Research.

Methods
This study obtained information regarding studies on Anterior Cruciate Ligament Reconstruction in Children and Adolescents from the Web of Science Core Collection database. Visual and bibliometric analysis were conducted using VOSviewer, Origin 2022, Pajek64 5.18and Excel 2019. These analytic tools facilitated the analysis of various aspects, including countries/regions, institutions, authors, journals and keywords related to the research.

Results
From 2003 to 2023, a total of 1328 articles were retrieved in WOS, and 637 articles were selected by two authors. The most productive institutions are Childrens Hosp Philadelphia, Kocher, ms. Their articles have the highest number of publications and citations. The American journal of sports medicine is the most frequently cited journal for articles on anterior cruciate ligament reconstruction in children and adolescents. The most common keywords used in these articles were “anterior cruciate ligament reconstruction”, “injury, children, adolescent”, and “skeletally immature patients”.

Conclusions
This study provides valuable insights into the research focus of anterior cruciate ligament reconstruction in children and adolescents. In recent years, there has been significant attention paid to areas of “the return to sport, re-repture rate and functional recovery after anterior cruciate ligament reconstruction” in this specific population. These aspects have emerged as key directions for future research in this field.
Effect of aligners on patients’ oral health-related quality of life and anxiety: a prospective pilot study
Authors: Roulias Panagiotis , Vasoglou Georgios , Angelopoulos Gerassimos , Pandis Nikolaos , Sifakakis Iosif 
Published: June 2024

Abstract
Background
This prospective study explored the impact of aligners on the oral health-related quality of life and anxiety of patients during the first month of orthodontic treatment and the first month of the retention phase.

Methods
A total of 23 male and female patients (median age 25 y) treated with clear aligners were included. The OHRQoL questionnaire was used at certain time points during treatment (T1: placement of the first aligner; T2: after one day of use; T3: after seven days; T4: after one month; and T5: after one month in the retention phase). The State-Trait Anxiety Inventory (STAI) was also self-administered to assess state and trait anxiety (Y1 and Y2 subscales, respectively) at the T1, T4 and T5 time points. A population average generalized estimating equations logistic regression model was fit to assess the effect of time on the responses, and the Wald test was used to examine the overall effect of time.

Results
Overall time was a significant predictor for most of the questions. However, time was marginally significant for the OHRQoL questions evaluating oral symptoms such as bad taste/smell, sores, and food accumulation. Tooth discolouration did not differ between time points. The general activity disturbance was significantly lower in the retention phase. Higher depression and anxiety scores were reported at the initial appointment and decreased thereafter.

Conclusions
CAT has a negative impact on quality of life and psychological status during the initial days of treatment. These impairments ameliorate at later treatment stages.
Review on micro-gas chromatography system for analysis of multiple low-concentration volatile organic compounds: preconcentration, separation, detection, integration, and challenges
Authors: Lee Yeongseok , Son Hyeonwoo , Lee Junwoo , Lim Si-Hyung 
Published: June 2024

AbstractAs the dangers of volatile organic compounds (VOCs) and their potential as non-invasive diagnosis biomarkers have been reported, there has been a need for instrument capable of real-time and in-situ monitoring of multiple low-concentration VOCs in indoor air or human metabolites. A promising technology that can qualitatively and quantitatively analyze numerous VOCs as an alternative to conventional bench-top instruments is a micro-gas chromatography (µ-GC) system, which integrates three main components: a micro-gas preconcentrator, a µ-GC column, and a mini- or micro-detector fabricated using microelectromechanical system (MEMS) processes. This review covers the integration methods, features, and analysis capabilities of recently developed µ-GC systems and examines the materials, designs, and principles of the three main components. In addition, the challenging issues that must be addressed for the commercialization of this technology are discussed.
Advancing machine learning with OCR2SEQ: an innovative approach to multi-modal data augmentation
Authors: Lowe Michael , Prusa Joseph D. , Leevy Joffrey L. , Khoshgoftaar Taghi M. 
Published: June 2024

AbstractOCR2SEQ represents an innovative advancement in Optical Character Recognition (OCR) technology, leveraging a multi-modal generative augmentation strategy to overcome traditional limitations in OCR systems. This paper introduces OCR2SEQ’s unique approach, tailored to enhance data quality for sequence-to-sequence models, especially in scenarios characterized by sparse character sets and specialized vocabularies. At the heart of OCR2SEQ lies a set of novel augmentation techniques designed to simulate realistic text extraction errors. These techniques are adept at generating diverse and challenging data scenarios, thereby substantially improving the training efficacy and accuracy of text-to-text transformers. The application of OCR2SEQ has shown notable improvements in data processing accuracy, particularly in sectors heavily dependent on OCR technologies such as healthcare and library sciences. This paper demonstrates the capability of OCR2SEQ to transform OCR systems by enriching them with augmented, domain-specific data, paving the way for more sophisticated and reliable machine learning interpretations. This advancement in OCR technology, as presented in the study, not only enhances the accuracy and reliability of data processing but also sets a new benchmark in the integration of augmented data for refining OCR capabilities.
Transcriptome analysis reveals potential genes associated with glyphosate resistance in cassava
Authors: Wang Bingyu , Li Junyi , Luo Kai , Wang Honggang , Gao Yu , Wang Yixuan , Zhang Tingting , Qi Jincun , Li Ruitao , Chen Yinhua 
Published: June 2024

AbstractGlyphosate, widely used to manage weeds in cassava crops, simultaneously inhibits cassava growth, necessitating the development of herbicide-tolerant cassava varieties. In this study, screened 262 cassava varieties, identifying the glyphosate-resistant (GR) variety ZM8701 and the glyphosate-sensitive (GS) variety SC9. Transcriptomic analysis via Illumina sequencing revealed differentially expressed genes associated with resistance, including Cytochrome P450, GST, GT, ABC transporters, and others such as MIOX1, LHCA1, PPH, HSP26, HSP83A, and UGT73C5. Notably, the EMB3004 gene, involved in the biosynthesis of aromatic amino acids, was significantly upregulated in resistant varieties, suggesting a key role in countering glyphosate’s inhibition of the shikimic acid pathway. These genes are pivotal in enhancing cell wall biosynthesis, optimizing photosynthesis, and improving detoxification processes. This research elucidated the molecular mechanisms underlying cassava’s resistance to glyphosate, thereby laying the groundwork for breeding programs aimed at developing herbicide-resistant varieties.
Graphical Abstract
Geofluid behavior prior to the 2018 Hokkaido Eastern Iburi earthquake: insights from groundwater geochemistry
Authors: Zandvakili Zahra , Nishio Yoshiro , Sano Yuji 
Published: June 2024

AbstractA notable decrease of groundwater Na/K ratios was observed several months before the 2018 Hokkaido Eastern Iburi earthquake (M6.7) at a site approximately 20 km west of the earthquake’s epicenter. To investigate the cause of the decreased Na/K ratios, we analyzed groundwater samples (commercially bottled drinking water) to assess the contribution of deep-derived fluids using Li and Sr isotopic ratios, which are reliable indicators of deep fluid contributions. No pronounced changes in the 7Li/6Li and 87Sr/86Sr ratios were observed; thus, the pre-earthquake decrease of groundwater Na/K ratios did not result from the input of deep-derived fluids. The pre-earthquake decrease in the Na/K ratio observed in this study may instead be related to CO2 influx into the aquifer. The CO2 may have leaked from carbon dioxide capture and storage (CCS), because CCS was in operation near the epicenter of the 2018 Hokkaido Eastern Iburi earthquake. Decreases of the Na/K ratios and increases of the CO2 concentrations in groundwater have been reported before other large earthquakes; thus, CO2 influx into groundwater may be a common phenomenon preceding earthquakes.
School principals’ instructional leadership as a predictor of teacher’s professional development
Authors: He Ping , Guo Fangyun , Abazie Genevive Anulika 
Published: June 2024

AbstractThis study investigates the role of school principals’ instructional leadership as a predictor of teachers’ professional development. The research sample comprised 304 secondary school teachers and 19 principals in Awka South, Anambra State, Nigeria. The study adopts Hallinger and Murphy’s (1985) Instructional Leadership Model. Data were collected using the “Principal’s Instructional Leadership Practices and Teachers’ Professional Development” (PILPTPD) tool. Correlation analysis was utilized to explore the relationship between school principals’ instructional leadership and teachers’ professional development, while multiple regression analysis was employed to ascertain the predictive capacity of instructional leadership on teacher professional development. The results reveal significant associations between instructional leadership and teacher professional development and growth. Ultimately, instructional leadership emerges as a significant predictor of teacher professional development. This study contributes to the expanding literature emphasizing the nexus between principal instructional leadership and teacher professional development, shedding light on the mediating role of principals’ leadership in influencing teachers’ professional development and instructional practices.
Effects of task structure and confirmation bias in alternative hypotheses evaluation
Authors: Dhami Mandeep K. , Belton Ian K. , De Werd Peter , Hadzhieva Velichka , Wicke Lars 
Published: June 2024

AbstractWe empirically examined the effectiveness of how the Analysis of Competing Hypotheses (ACH) technique structures task information to help reduce confirmation bias (Study 1) and the portrayal of intelligence analysts as suffering from such bias (Study 2). Study 1 (N = 161) showed that individuals presented with hypotheses in rows and evidence items in columns were significantly less likely to demonstrate confirmation bias, whereas those presented with the ACH-style matrix (with hypotheses in columns and evidence items in rows) or a paragraph of text (listing the evidence for each hypothesis) were not less likely to demonstrate bias. The ACH-style matrix also did not confer any benefits regarding increasing sensitivity to evidence credibility. Study 2 showed that the majority of 62 Dutch military analysts did not suffer from confirmation bias and were sensitive to evidence credibility. Finally, neither judgmental coherence nor cognitive reflection differentiated between better or worse performers in the hypotheses evaluation tasks.
Application of fluidized-bed homogeneous crystallization technology to carbon sequestration and recovery from flue gas
Authors: Huang Po-Chun , Vilando Anabella C. , Ha Thi-Hanh , Lu Ming-Chun 
Published: June 2024

AbstractThe Earth’s energy balance produced by human activity is the main factor in the complex relationship between greenhouse gases and global warming. The Taiwan Environmental Protection Agency reports that carbon dioxide makes up more than 95% of Taiwan’s most recent greenhouse gas emissions. This study used fluidized-bed homogeneous crystallization (FBHC) technology to recover carbonate in a simulated CO2-enriched flue gas. It was specifically designed to determine how carbonate removal and crystallization efficiency were affected by carbonate surface loading, the influence of the source of calcium ions, and interfering substances. Results revealed that the best surface loading at 55 kg m− 2 h− 1 achieved 93% removal and 84% crystallization efficiency. At 50 mg L− 1 of sulfate ions, the presence of more interfering compounds tends to reduce carbonate removal to 97% and 91% crystallization. Regarding X-ray diffraction data, the recovered carbonate crystals resembled calcium carbonate crystals. It has been demonstrated that carbonate can be recovered using FBHC technology as a method of CO2 capture and storage.
Impact of a Regional Pediatric Hematology/Oncology Fellowship Program in Guatemala
Authors: Moreira Daniel C. , Garrido Claudia , Rosado Roy , Girón Verónica , Letona Tomás , Morales Gerson , Valverde Patricia , Velásquez Thelma , Alfaro Jeanine , Orellana Elizabeth , Ortega Miguel Angel , Salguero Paola , Fox Irwin Leeanna , Andujar Allyson , de Alarcón Pedro A. , Luna-Fineman Sandra , Manco-Johnson Marilyn , Conter Valentino , Verna Marta , Canesi Marta , Massimino Maura , Spreafico Filippo , Ferrari Andrea , Gassant Pascale Y. , Vásquez Roberto , Friedrich Paola , Mack Ricardo , Ribeiro Raul , Metzger Monika L. , Rodriguez-Galindo Carlos , Antillón-Klussmann Federico 
Published: June 2024

PURPOSE This study aimed to describe and assess the regional experience of a pediatric hematology/oncology fellowship program based in Guatemala. METHODS The Unidad Nacional de Oncología Pediátrica (UNOP) in Guatemala City, Guatemala, is the only hospital in Central America dedicated exclusively to childhood and adolescent cancer. To address the regional need for specialists, a fellowship program in pediatric hematology/oncology was launched in 2003. The UNOP fellowship program comprises 3 years of training. Although the program is based at UNOP, it also includes rotations locally and internationally to enhance clinical exposure. The curriculum is based on international standards to cover clinical expertise, research, professionalism, communication, and health advocacy. Trainees are selected according to country or facility-level need for pediatric hematologists/oncologists, with a plan for them to be hired immediately after completing their training. RESULTS Forty physicians from 10 countries in Latin America have completed training. In addition, there are currently 13 fellows from five countries in training. Of the graduates, 39 (98%) are now practicing in pediatric hematology/oncology in Latin America. Moreover, many of them have leadership positions within their institutions and participate in research, advocacy, and policy making. Graduates from the UNOP program contribute to institutions by providing care for an increasing number of patients with pediatric cancer. The UNOP program is the first pediatric hematology/oncology fellowship program in the world to be accredited by Accreditation Council for Graduate Medical Education-International, an international body accrediting clinical training programs. CONCLUSION The UNOP program has trained specialists to increase the available care for children with cancer in Latin America. This regional approach to specialist training can maximize resources and serve as a model for other programs and regions.
SARC037: Phase II results of trabectedin given as a 1-hour (h) infusion in combination with low dose irinotecan in patients (pts) with relapsed/refractory Ewing sarcoma (ES).
Authors: Grohar Patrick Joseph , Ballman Karla V. , Heise Rachel , Mascarenhas Leo , Glod John , Wedekind Mary Frances Frances , Gedminas Jenna Marie , DuBois Steven G. , Maki Robert G. , Crompton Brian D. , Figg William Douglas , Bagatell Rochelle , Laetsch Theodore Willis , Diamond Mark , Navid Fariba , Roberts Ryan David , Widemann Brigitte C. , Reinke Denise K. , Chugh Rashmi 
Published: June 2024

11508 Background: Trabectedin(T) is a marine-derived minor groove DNA binding compound that alters transcription factor activity. Preclinical data suggests that T suppresses the oncogenic driver of ES, EWS::FLI1. This suppression requires a threshold concentration of T and is potentiated by low doses of Irinotecan(I). Preliminary clinical activity and reversal of the EWS::FLI1 transcriptome was seen in patients (pts) in the phase I portion of SARC037. Here we report the phase II results of T with I at the recommended dose in pts with relapsed/refractory ES. Methods: In this open-label multicenter study, T was given at 1 mg/m2 as a 1-h infusion on day(D)1 with I at 25 mg/m2 intravenously on D2 and D4 of a 21D cycle. Key eligibility criteria were EWS::FLI1 fusion transcript, age ≥6 years, ECOG ≤2, adequate organ function, and willing to have a research biopsy if safely accessible. The primary objective was to determine the objective response rate (ORR) assessed by RECIST v1.1. Secondary objectives were progression-free survival (PFS), duration of response (DOR), and safety. This study used a Simon two-stage design that required 4 or more responses (CR or PR) at the final analysis to establish treatment activity. Results: 18 pts enrolled from 12/2022-12/2023 across 6 sites, 8F/10M, median age 21y (9-43). Pts had a median of 3 (1-7) prior therapy lines, including I in 67% of pts. Of 16 pts evaluable for response at the cutoff date, 5 pts had a PR, and 2 pts had SD. Two pts have evaluations pending and two pts were removed for toxicity before the first evaluation. Median time to response was 2.6 months(m), 6-month PFS was 37.7% (95% CI 18.3%, 77.7%), and all responses were sustained at the time of data cutoff at 10.4+, 7.5+, 5.5+, 5.0+ and 4.6+ m. There were no G5 AEs. Most pts had molecular profiling, translocation testing, as well as ctDNA collection, quantitation, and analysis. A subset of pts had pre- and post-treatment biopsies for RNA sequencing and evaluation of the impact of drug exposure on the EWS::FLI1 transcriptome. Conclusions: T+I exhibited anti-tumor activity in heavily pretreated pts with ES and met its prespecified ORR with 5 PRs in 16 evaluable patients, all of which are ongoing at data cutoff. There were no unexpected safety signals. The combination of T given as a 1h infusion and low-dose I demonstrated meaningful clinical benefit and is worthy of further study in ES pts. Analysis of biological correlates is ongoing. Clinical trial information: NCT04067115 .
The CT-based multi-omics model for prognostic prediction and tumor microenvironmental alterations in retroperitoneal liposarcoma: A retrospective multicohort analysis.
Authors: Fan Peidang , Tao Ping , Wang Zhenyu , Wang Jiongyuan , Zhang Long Jiu , Hou Yong Ying , Hong Liang , Ma Lijie , Zhang Yong , Tong Hanxing 
Published: June 2024

11564 Background: Retroperitoneal liposarcomas (RPLS) are tumours with a poor prognosis. Due to the tumour heterogeneity of RPLS, no effective prognostic index has been established. Radiomics has the potential to non-invasively characterize the so-called radiological phenotype of RPLS. We aimed to develop and independently validate a CT-based multi-omics model for predicting prognosis and tumour microenvironment (TIME) in RPLS to guide neoadjuvant therapy in clinical application. Methods: In this retrospective multicohort study, we used five independent cohorts of RPLS patients at our centre (n = 173, Zhongshan hospital, Fudan University, China), and the external validation cohort comprising RPLS patients from another medical centre (n = 184, Shanghai Public Health Clinical Center, Fudan University, China), to develop and validate a CT-based multi-omics model predictive of neoadjuvant chemotherapy (n = 10) and radiotherapy (n = 20) response by combining contrast-enhanced CT images and RNA-seq genomic data (n = 59) from tumour samples to assess the immune and metabolic landscape. Using the training dataset, a CT-based radiomics workflow was developed, including manual delineation, sub-segmentation, feature extraction, and predictive model building by LASSO, which was validated according to the area under the curve (AUC) for the internal validation set and external validation set. The clinical-radiomic model was developed through Univariate and Multivariate Cox regression analysis. Kaplan-Meier and log-rank tests were used for the survival analysis. Results: A total of 436 patients recruited between September 2009 and October 2021 were included in the training, internal validation, and external validation sets. The OS-related CT-based radiomics models in the training, internal validation, and external validation sets predicted the AUC values of postoperative 5-year OS as 0.71, 0.85, and 0.82, respectively. Strikingly, the clinical-CT radiomics model showed superior prognostic ability in predicting postoperative 5-year OS of 0.83, 0.85, and 0.86. Furthermore, the clinical-CT radiomics risk score was significantly decreased in post-neoadjuvant chemotherapy and radiotherapy with more tertiary lymphoid structures (TLS) and immune cell infiltration, such as plasma cells and B cells, compared to pretreatment. KEGG and ssGSEA analysis further indicated that retinol metabolism was most significantly inhibited in the high clinical-CT radiomics risk score group. Conclusions: Our validated clinical-CT radiomics model can predict the prognosis and TIME of RPLS with excellent performance. This may be a promising way to improve prognosis prediction and risk stratification of patients treated with neoadjuvant therapy, when validated by further prospective randomised trials.