bluuebunny/crossref_metadata_2025_split huggingface dataset:
Micro‐computed tomographic evaluation of fetal skeletal changes induced by all‐trans‐retinoic acid in rats and rabbits
Authors: Wise L. David , Xue Dahai , Winkelmann Christopher T. 
Published: September 2010

AbstractBACKGROUND: Our laboratory has been conducting positive control studies to evaluate the utility of micro‐computed tomography (micro‐CT) for qualitative evaluation of fetal skeletal morphology. All‐trans‐retinoic acid (atRA) was used to produce a different spectrum of defects compared to our previous studies with boric acid and hydroxyurea. METHODS: Groups of five mated Crl:CD(SD) female rats each were administered vehicle or atRA (2.5–50 mg/kg) on GD 10, and groups of four mated Dutch Belted rabbits each were dosed with vehicle or atRA (6.25–25 mg/kg) on GD 9. Cesarean sections were performed on GD 21 and 28, respectively. Following external examination the viscera were removed and fetuses scanned in a micro‐CT imaging system. Fetuses were subsequently stained with alizarin red. Skeletal morphology was evaluated by each method without the knowledge of treatment group. Total bone mineral content (BMC) of each fetus was quantitated using the micro‐CT images. RESULTS: In rats there were dose‐related increases in the incidence of extra lumbar vertebra and non‐dose‐related increases in supernumerary ribs at all dose levels. There were decreases in mean number of ossified sacrocaudal vertebra at ≥5 mg/kg, and increases in skull bone malformations at ≥10 mg/kg. Rabbits were less sensitive on a mg/kg basis since skeletal malformations and a decrease in mean number of ossified sacrocaudal vertebra were observed only in the 25‐mg/kg group. Micro‐CT evaluation detected essentially the same incidence of skeletal abnormalities as seen in alizarin red‐stained rat and rabbit fetuses. BMC analysis showed a trend toward slight decreases in atRA‐treated rats, but no notable changes in rabbits. CONCLUSIONS: These results add support to our previous work that demonstrates that micro‐CT imaging can effectively assess rat and rabbit fetal skeletal morphology. Birth Defects Res (Part B) 89:408–417, 2010. © 2010 Wiley‐Liss, Inc.
Fucoxanthin‐rich seaweed extract suppresses body weight gain and improves lipid metabolism in high‐fat‐fed C57BL/6J mice
Authors: Jeon Seon‐Min , Kim Hye‐Jin , Woo Myoung‐Nam , Lee Mi‐Kyung , Shin Young Chul , Park Yong Bok , Choi Myung‐Sook 
Published: September 2010

AbstractAn ethanol extract of fucoxanthin‐rich seaweed was examined for its effectiveness as a nutraceutical for body fat‐lowering agent and for an antiobese effect based on mode of actions in C57BL/6J mice. Animals were randomized to receive a semi‐purified high‐fat diet (20% dietary fat, 10% corn oil and 10% lard) supplemented with 0.2% conjugated linoleic acid (CLA) as the positive control, 1.43% or 5.72% fucoxanthin‐rich seaweed ethanol extract (Fx‐SEE), equivalent to 0.05% or 0.2% dietary fucoxanthin for six weeks. Results showed that supplementation with both doses of Fx‐SEE significantly reduced body and abdominal white adipose tissue (WAT) weights, plasma and hepatic triglyceride (TG), and/or cholesterol concentrations compared to the high‐fat control group. Activities of adipocytic fatty acid (FA) synthesis, hepatic FA and TG synthesis, and cholesterol–regulating enzyme were also lowered by Fx‐SEE supplement. Concentrations of plasma high‐density lipoprotein‐cholesterol, fecal TG and cholesterol, as well as FA oxidation enzyme activity and UCP1 mRNA expression in epididymal WAT were significantly higher in the Fx‐SEE groups than in the high‐fat control group. CLA treatment reduced the body weight gain and plasma TG concentration. Overall, these results indicate that Fx‐SEE affects the plasma and hepatic lipid profile, fecal lipids and body fat mass, and alters hepatic cholesterol metabolism, FA synthesis and lipid absorption.
Necessary and sufficient conditions for the asymmetric synthesis of chiral amines using ω‐aminotransferases
Authors: Seo Joo‐Hyun , Kyung Dohyun , Joo Keehyoung , Lee Jooyoung , Kim Byung‐Gee 
Published: September 2010

AbstractThe half reactions of ω‐aminotransferase (ω‐AT) from Vibrio fluvialis JS17 (ω‐ATVf) were carried out using purified pyridoxal 5′‐phosphate‐enzyme (PLP‐Enz) and pyridoxamine 5′‐phosphate‐enzyme (PMP‐Enz) complexes to investigate the relative activities of substrates. In the reaction generating PMP‐Enz from PLP‐Enz using L‐alanine as an amine donor, L‐alanine showed about 70% of the initial reaction rate of (S)‐α‐methylbenzylamine ((S)‐α‐MBA). However, in the subsequent half reaction recycling PLP‐Enz from PMP‐Enz using acetophenone as an amine acceptor, acetophenone showed nearly negligible reactivity compared to pyruvate. These results indicate that the main bottleneck in the asymmetric synthesis of (S)‐α‐MBA lies not in the amination of PLP by alanine, but in the amination of acetophenone by PMP‐Enz, where conformational restraints of the enzyme structure is likely to be the main reason for limiting the amine group transfer from PMP‐Enz to acetophenone. Based upon those half reaction experiments using the two amino acceptors of different activity, it appears that the relative activities of the two amine donors and the two acceptors involved in the ω‐AT reactions can roughly determine the asymmetric synthesis yield of the target chiral amine compound. Predicted conversion yields of several target chiral amines were calculated and compared with the experimental conversion yields. Approximately, a positive linear correlation (Pearson's correlation coefficient = 0.92) was observed between the calculated values and the experimental conversion yields. To overcome the low (S)‐α‐MBA productivity of ω‐ATVf caused by the possible disadvantageous structural constraints for acetophenone, new ω‐ATs showing higher affinity to benzene ring of acetophenone than ω‐ATVf were computationally screened using comparative modeling and protein‐ligand docking. ω‐ATs from Streptomyces avermitilis MA‐4680 (SAV2612) and Agrobacterium tumefaciens str. C58 (Atu4761) were selected, and the two screened ω‐ATs showed higher asymmetric synthesis reaction rate of (S)‐α‐MBA and lower (S)‐α‐MBA degradation reaction rate than ω‐ATVf. To verify the higher conversion yield of the variants of ω‐ATs, the reaction with 50 mM acetophenone and 50 mM alanine was performed with coupling of lactate dehydrogenase and two‐phase reaction system. SAV2612 and Atu4761 showed 70% and 59% enhanced yield in the synthesis of (S)‐α‐MBA compared to that of ω‐ATVf, respectively. Biotechnol. Bioeng. 2011;108: 253–263. © 2010 Wiley Periodicals, Inc.
Production of Dehydrogingerdione Derivatives in Escherichia coli by Exploiting a Curcuminoid Synthase from Oryza sativa and a β‐Oxidation Pathway from Saccharomyces cerevisiae
Authors: Katsuyama Yohei , Ohnishi Yasuo , Horinouchi Sueharu 
Published: September 2010

AbstractGingerol derivatives are bioactive compounds isolated from the rhizome of ginger. They possess various beneficial activities, such as anticancer and hepatoprotective activities, and are therefore attractive targets of bioengineering. However, the microbial production of gingerol derivatives has not yet been established, primarily because the biosynthetic pathway of gingerol is unknown. Here, we report the production of several dehydrogingerdione (a gingerol derivative) analogues from a recombinant Escherichia coli strain that has an “artificial” biosynthesis pathway for dehydrogingerdione that was not based on the original biosynthesis pathway of gingerol derivatives in plants. The system consists of a 4‐coumarate:CoA ligase from Lithospermum erythrorhizon, a fatty acid CoA ligase from Oryza sativa, a β‐oxidation system from Saccharomyces cerevisiae, and a curcuminoid synthase from O. sativa. To our knowledge, this is the first report of the microbial production of a plant metabolite the biosynthetic pathway of which has not yet been identified.
Catalytic Aerobic Dehydrogenative Coupling of Primary Alcohols and Water to Acids Promoted by a Rhodium(I) Amido N‐Heterocyclic Carbene Complex
Authors: Annen Samuel , Zweifel Theo , Ricatto Federica , Grützmacher Hansjörg 
Published: September 2010

AbstractThe amino diolefin complex [Rh(trop2NH)(TMIY)]+(OTf)− (OTf−=CF3SO3−; trop=5‐H‐dibenzo[a,d]cyclohepten‐5yl), incorporating N‐heterocyclic carbene ligand 1,3,4,5‐tetramethylimidazole‐2‐ylidene (TMIY), has been prepared. The structure is determined by single‐crystal X‐ray diffraction, which shows a butterfly structure with the NH and TMIY groups in the apical and the two olefinic binding sites in the equatorial position of a trigonal bipyramid with one vacant site in the equatorial plane. This complex can be deprotonated to give the amide [Rh(trop2N)(TMIY)], which cleaves H2 heterolytically across the RhN bond to give the amino hydride [RhH(trop2NH)(TMIY)]. In dimethylsulfoxide (DMSO), both the amide and amino hydride complexes are active as catalysts in the dehydrogenative coupling (DHC) of various primary alcohols with water to give the corresponding acids under aerobic conditions. O2 serves as hydrogen acceptor. One O atom is converted into water while the other is transferred to DMSO as oxygen acceptor, to yield Me2SO2. Hence, the net reaction RCH2OH+2 O2+2 DMSO→RCOOH+2 Me2SO2+H2O is catalyzed by the butterfly‐shaped rhodium amide complexes.
Functionalized Alkynylplatinum(II) Polypyridyl Complexes for Use as Sensitizers in Dye‐Sensitized Solar Cells
Authors: Kwok Eric Chi‐Ho , Chan Mei‐Yee , Wong Keith Man‐Chung , Lam Wai Han , Yam Vivian Wing‐Wah 
Published: September 2010

AbstractA series of platinum(II) alkynyl‐based sensitizers has been synthesized and found to show light‐to‐electricity conversion properties. These dyes were developed as sensitizers for the application in nanocrystalline TiO2 dye‐sensitized solar cells (DSSCs). Their photophysical and electrochemical properties were studied. The excited‐state property was probed using nanosecond transient absorption spectroscopy, which showed the formation of a charge‐separated state that arises from the intramolecular photoinduced charge transfer from the platinum(II) alkynylbithienylbenzothiadiazole moiety (donor) to the polypyridyl ligand (acceptor). A lifetime of 3.4 μs was observed for the charge‐separated state. A dye‐sensitized solar cell based on one of the complexes showed a short‐circuit photocurrent of 7.12 mA cm−2, an open circuit voltage of 780 mV, and a fill factor of 0.65, thus giving an overall power conversion efficiency of 3.6 %.
ChemInform Abstract: Gas‐Phase Electron Diffraction Study of Ruthenium(V) Fluoride and Osmium(V) Fluoride.
Authors: PAGE E. M. , RICE D. A. , ALMOND M. J. , HAGEN K. , VOLDEN H. V. , HOLLOWAY J. H. , HOPE E. G. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Influence of Surface Composition of Perovskite‐Type Complex Oxides on Methane Oxidative Coupling.
Authors: DING W. , CHEN Y. , FU X. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Coupled Substitution of Niobium and Silicon in KTiOPO4 and KTiOAsO4. Synthesis and Nonlinear Optical Properties of KTi1‐xNbxOX1‐xSixO4 (X: P, As).
Authors: RANGAN K. K. , PRASAD B. R. , SUBRAMANIAN C. K. , GOPALAKRISHNAN J. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: X‐Ray Study on Mn2V2O7‐M2V2O7 Systems (M: Ba, Sr, Ca, Co, Zn, Cu, Ni).
Authors: ZHURAVLEV V. D. , VELIKODNYI YU. A. , SURAT L. L. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Optical Resolution of 2‐ and 3‐Hydroxyalkyltriphenylphosphonium Salts. Stereoselective Synthesis of Enantiomerically Pure (E)‐ and (Z)‐ Homoallylic Alcohols.
Authors: OKUMA K. , TANAKA Y. , OHTA H. , MATSUYAMA H. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Sequential Kinetic Resolution of (.+‐.)‐2,3‐Butanediol in Organic Solvent Using Lipase from Pseudomonas cepacia.
Authors: CARON G. , KAZLAUSKAS R. J. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Microbial Synthesis of (2R,3S)‐(‐)‐N‐benzoyl‐3‐phenyl Isoserine Ethyl Ester‐a Taxol Side‐Chain Synthon.
Authors: PATEL R. N. , BANERJEE A. , HOWELL J. M. , MCNAMEE C. G. , BROZOZOWSKI D. , MIRFAKHRAE D. , NANDURI V. , THOTTATHIL J. K. , SZARKA L. J. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Baker′s Yeast Reduction of 2‐(2‐Nitroethyl)‐1‐cycloalkanones.
Authors: FELLUGA F. , NITTI P. , PITACCO G. , VALENTIN E. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Diels‐Alder Reactions of Thebaines with Cycloalkenones; Lithium Tetrafluoroborate as a Novel Diels‐Alder Catalyst.
Authors: BARTON J. W. , COOP A. , LEWIS J. W. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Synthesis of Diterpenoid Intermediates.
Authors: KHAN N. , LARSEN L. , SUTHERLAND J. K. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Further Improvements in Isomerization of Olefins in Solvent‐Free Conditions.
Authors: THACH L. N. , HANH D.‐L. , HIEP N. B. , RADHAKRISHNA A. S. , SINGH B. B. , LOUPY A. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Incorporation of Promoter Elements into the Crystal Lattice of (VO) 2P2O7 and Its Promotion Effects on the Oxidation of n‐Butane to Maleic Anhydride.
Authors: TAKITA Y. , TANAKA K. , ICHIMARU S. , MIZIHARA Y. , ABE Y. , ISHIHARA T. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Atropisomer‐Selective 1,1‐Binaphthyl Synthesis via Chirality Transfer from Sulfur.
Authors: BAKER R. W. , POCOCK G. R. , SARGENT M. V. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Convenient Route to β‐Aryl‐Substituted Cyclic Enamines as Key Synthetic Intermediates of Sceletium and Amaryllidaceae Alkaloids.
Authors: MATSUMURA Y. , TERAUCHI J. , YAMAMOTO T. , KONNO T. , SHONO T. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Convenient Synthesis of 9(11)‐Dehydrosteroids from 11β‐Hydroxy Steroids.
Authors: ZHAO Q. , LI Z. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reaction of α‐Cyanoacrylates with Functionally‐Substituted Thiols, Ethanedithiol, and Hydrogen Sulfide.
Authors: KANDROR I. I. , BRAGINA I. O. , GALKINA M. A. , GUSEVA T. I. , LAVRUKHIN B. D. , GOLOLOBOV YU. G. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel Efficient Preparation of Haloadamantanes with Participation of Rhodium Complexes.
Authors: KHUSNUTDINOV R. I. , SHCHADNEVA N. A. , DZHEMILEV U. M. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regioselective and Reproducible Mononitration of 3‐Methoxyacetanilide.
Authors: GOKHALE U. B. , JOSHI A. A. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Arylpropanoic Acids from Optically Active 2‐(Iodophenyl) propanoic Acids.
Authors: HAMON D. P. G. , MASSY‐WESTROPP R. A. , NEWTON J. L. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Unusual Amino Acids. Part 5. Asymmetric Hydrogenation of (Z)‐N‐ Acylaminocinnamic Acid Derivatives Bearing Different Protective Groups.
Authors: KREUZFELD H.‐J. , DOEBLER C. , KRAUSE H. W. , FACKLAM C. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation and Structure of a Tetrasubstituted Derivative of N′′‐ Cyanoguanidine, N,N,N′,N′‐Tetrabenzyl‐N′′‐cyanoguanidine.
Authors: SHIBA R. , TAKAHASHI M. , SHINOZAKI H. , EBISUNO T. , TAKIMOTO M. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Synthesis of a Novel Iptycene Containing the Triphenylene Unit.
Authors: RAYMO F. M. , PARISI M. F. , KOHNKE F. H. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Convenient Synthesis of Substituted 3‐Pyrrolin‐2‐ones from α‐ Ketols.
Authors: MELIKIAN G. , ROUESSAC F. , ALEXANDRE C. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Studies in Antiparasitic Agents. Part 20. Synthesis of Probenzimidazoles, Benzimidazoles, and Pyrimido(1,2‐a)benzimidazoles as Possible Anthelmintics.
Authors: SRIVASTAVA R. P. , SINGH S. K. , ABUZAR S. , SHARMA S. , GUPTA S. , KATIYAR J. C. , CHATTERJEE R. K. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Improved Syntheses of 2‐Bromonicotinaldehyde and Acid.
Authors: MELNYK P. , GASCHE J. , THAL C. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.