bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural Origins of Silk Piezoelectricity
Authors: Yucel Tuna , Cebe Peggy , Kaplan David L. 
Published: January 2011

AbstractUniaxially oriented, piezoelectric silk films are prepared by a two‐step method that involves first air drying aqueous, regenerated silk fibroin solutions into films, and then drawing the silk films to a desired draw ratio. The utility of two different drawing techniques—zone drawing and water‐immersion drawing—is investigated for processing the silk for piezoelectric studies. Silk films zone drawn to a ratio of λ 5 2.7 display relatively high dynamic shear piezoelectric coefficients of d14 5 –1.5 pC N21, corresponding to an increase in d14 of over two orders of magnitude due to film drawing. A strong correlation is observed between the increase in silk II, β‐sheet content with increasing draw ratio as measured by FTIR spectroscopy (Cb $ \propto $ e2.5λ), the concomitant increasing degree of orientation of β‐sheet crystals detected via wide‐angle X‐ray diffraction (full width half maximum (FWHM) = 0.22° for λ = 2.7), and the improvement in silk piezoelectricity (d14 $ \propto $ e2.4λ). Water‐immersion drawing leads to a predominantly silk I structure with a low degree of orientation (FWHM 5 75°) and a much weaker piezoelectric response compared to zone drawing. Similarly, increasing the β‐sheet crystallinity without inducing crystal alignment, e.g., by methanol treatment, does not result in a significant enhancement of silk piezoelectricity. Overall, a combination of a high degree of silk II, β‐sheet crystallinity and crystalline orientation are prerequisites for a strong piezoelectric effect in silk. Further understanding of the structural origins of silk piezoelectricity provides important options for future biotechnological and biomedical applications of this protein.
A de novo deletion of 20q11.2–q12 in a boy presenting with abnormal hands and feet, retinal dysplasia, and intractable feeding difficulty
Authors: Hiraki Yoko , Nishimura Akira , Hayashidani Michiko , Terada Yoshiko , Nishimura Gen , Okamoto Nobuhiko , Nishina Sachiko , Tsurusaki Yoshinori , Doi Hiroshi , Saitsu Hirotomo , Miyake Noriko , Matsumoto Naomichi 
Published: January 2011

AbstractProximal interstitial deletions involving 20q11–q12 are very rare. Only two cases have been reported. We describe another patient with 20q11.21–q12 deletion. We precisely mapped the 6.5‐Mb deletion and successfully determined the deletion landmarks at the nucleotide level. Common clinical features among the three cases include developmental delay, intractable feeding difficulties with gastroesophageal reflux, and facial dysmorphism including triangular face, hypertelorism, and hypoplastic alae nasi, indicating that the 20q11.2–q12 deletion can be a clinically recognizable syndrome. This is also supported by the fact that the three deletions overlap significantly. In addition, unique features such as arthrogryposis/fetal akinesia (hypokinesia) deformation and retinal dysplasia are recognized in the patient reported herein. © 2011 Wiley‐Liss, Inc.
Fanconi–Bickel syndrome: Report of life history and successful pregnancy in an affected patient
Authors: Pena Loren , Charrow Joel 
Published: January 2011

AbstractFanconi–Bickel syndrome (FBS, OMIM #227810) is a rare autosomal recessive disorder of carbohydrate transport originally described in 1949 [Fanconi and Bickel(1949); Helv Paediatr Acta 4: 359–396]. FBS is caused by mutations in the glucose and galactose transporter gene SLC2A2 (HGNC ID11006) [Santer et al.(1997); Nat Genet 17: 324–326] and is characterized by hepatic glycogen accumulation with hepatomegaly, fasting hypoglycemia, short stature, impaired glucose tolerance, hyperlipidemia, and tubular nephropathy. Although the described complications would not seem to preclude fertility in FBS patients, there has been no report of reproduction in affected individuals to date. We have followed a female with FBS for at least 20 years. She received a clinical diagnosis in adolescence, with recent molecular confirmation of two mutations in trans in the SLC2A2 gene. She has had glucosuria, proteinuria, impaired tubular reabsorption of phosphate, osteopenia, and hypercholesterolemia throughout her life, without any documented episodes of hypoglycemia. Hepatomegaly was initially noticed in infancy and resolved in late adolescence. She became pregnant at 31 years of age, had gestational diabetes treated with diet, and delivered a healthy boy. She had impaired glucose tolerance after her pregnancy. Her adult height was at the lower end of her target height range, and she had evidence of localized osteopenia at the left distal radius on DXA scan. This report describes the clinical history of an affected individual and highlights the importance of continued follow‐up in order to extend our understanding of the history of this rare metabolic disorder. © 2011 Wiley‐Liss, Inc.
Mutational analysis reveals the FUS homolog TAF15 as a candidate gene for familial amyotrophic lateral sclerosis
Authors: Ticozzi N. , Vance C. , LeClerc A.L. , Keagle P. , Glass J.D. , McKenna‐Yasek D. , Sapp P.C. , Silani V. , Bosco D.A. , Shaw C.E. , Brown R.H. , Landers J.E. 
Published: January 2011

AbstractFUS, EWS, and TAF15 belong to the TET family of structurally similar DNA/RNA‐binding proteins. Mutations in the FUS gene have recently been discovered as a cause of familial amyotrophic lateral sclerosis (FALS). Given the structural and functional similarities between the three genes, we screened TAF15 and EWS in 263 and 94 index FALS cases, respectively. No coding variants were found in EWS, while we identified six novel changes in TAF15. Of these, two 24 bp deletions and a R388H missense variant were also found in healthy controls. A D386N substitution was shown not to segregate with the disease in the affected pedigree. A single A31T and two R395Q changes were identified in FALS cases but not in over 1,100 controls. Interestingly, one of the R395Q FALS cases also harbors a TARDBP mutation (G384R). Altogether, these results suggest that additional studies are needed to determine whether mutations in the TAF15 gene represent a cause of FALS. © 2011 Wiley‐Liss, Inc.
Effect of model choice in genetic association studies: DRD4 exon III VNTR and cigarette use in young adults
Authors: Das Debjani , Tan Xiaoyun , Easteal Simon 
Published: January 2011

AbstractA major concern with the vast literature associating the highly polymorphic 48 bp VNTR in exon III of the human dopamine receptor D4 gene (DRD4) with various behavioral phenotypes is the lack of concordance between studies. Part of the problem arises from the absence of a universally accepted scheme for pooling the large number of low frequency genotypes into appropriate categories. Here, we investigated the effect of different pooling strategies and genetic models on the reported association between DRD4‐exIII‐VNTR polymorphism and cigarette smoking. Genotyping was performed on a large randomly selected community‐based sample of 2,274 individuals aged 20–24 years. Participants were grouped into sub‐samples based on their genotypes to test specific genetic models. Multiple regression analyses were used to assess the relationship between DRD4‐exIII‐VNTR genotype and cigarette smoking measures while controlling for confounders. While smoking status and age at start of smoking were not associated with the genotype, a significantly (P = 0.006) higher rate of cigarette consumption was observed among carriers of the 7‐repeat (7r) allele. Thus, 7r carriers were not more likely to be smokers but if they did smoke they consumed significantly more cigarettes per day than 4r carriers. Unlike previous studies this association was observed only when comparing carriers of the 7r with the 4r but not the other repeat alleles. Our study demonstrates the need for caution when grouping functionally different DRD4‐exIII‐VNTR alleles in association studies. It particularly highlights the requirement for better functional characterization of the DRD4‐exIII‐VNTR alleles for interpreting results from association studies. © 2011 Wiley‐Liss, Inc.
Melt‐mixed polypropylene/acrylonitrile‐butadiene‐styrene blends with multiwall carbon nanotubes: Effect of compatibilizer and modifier on morphology and electrical conductivity
Authors: Khare Rupesh A. , Bhattacharyya Arup R. , Kulkarni Ajit R. 
Published: January 2011

AbstractCocontinuous blends of 45/55 polypropylene (PP)/acrylonitrile‐butadiene‐styrene (ABS) with multiwall carbon nanotubes (MWNT) were prepared by melt‐mixing in a conical twin‐screw microcompounder. PP‐grafted‐maleic anhydride (PP‐g‐MA) and styrene MA were used as compatibilizers for PP/ABS blends. Scanning electron microscopic observations showed phase segregation of PP‐g‐MA in the blends. State of dispersion of MWNT in the presence or absence of the compatibilizers was assessed through AC electrical conductivity measurements and crystallization studies of the blends. An improvement in AC electrical conductivity was observed in blends in presence of either styrene MA or dual compatibilizers. The lowest electrical percolation threshold was achieved at 0.1 wt % of MWNT using sodium salt of 6‐amino hexanoic acid‐modified MWNT. Significant increase in crystallization temperature of PP phase of blends with MWNT was observed in the presence of compatibilizers as compared to blends without compatibilizers. An attempt has been made to address the complex issues of phase segregation, compatibilization, and dispersion of MWNT in cocontinuous blends of PP/ABS. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Optical and electronic properties of 3,4‐dialkylthiophene‐based p‐/n‐alternating copolymers
Authors: Qi Zheng‐Jian , Wang Xue‐Mei , Wei Bin , Kang Feng , Tang Lan‐Lan , Hong Man‐Xin , Sun Yue‐Ming 
Published: January 2011

AbstractFour novel highly soluble p‐/n‐poly[(2,5‐divinyl‐3,4‐dialkylthiophene)‐alt‐2,6‐pyridine] (PA2TV‐Py) and poly[(2,5‐divinyl‐3,4‐dialkylthiophene)‐alt‐(2,5‐diphenyl‐1,3,4‐oxadiazole)] (PA2TV‐OXD) are prepared by Heck coupling approach to compare their photoelectric properties. Characterizations of the copolymers include FT‐IR, 1H‐NMR, gel permeation chromatography (GPC), thermogravimetric analysis (TGA), UV–vis spectroscopy, photoluminescence (PL), and electroluminescence (EL). Four alt‐copolymers exhibit excellent solubility in common organic solvents (e.g., CHCl3, THF) and good thermal stabilities, losing less than 5% on heating to ∼ 250°C. The optical properties depict that the band‐gap energy of PA2TV‐Py and PA2TV‐OXD is similarly, ranging from 2.68 to 2.80 eV in solid film and 2.90–2.97 eV in CHCl3 solution. PA2TV‐Pys can emit bright turquoise light with quantum efficiencies (QE) of 30.6 and 53.9%, which about 10‐18 times higher than that of homopolymer in CHCl3 solution. Furthermore, the QE of two PA2TV‐OXDs (purple fluorescence) are increased to 43.6 and 68.5%, respectively, about 1.3–1.4 times higher than that of PA2TV‐Pys. Electrochemical results indicate that the electron affinity (Ea) of four alt‐copolymers range from 2.79 to 3.09 eV, which are propitious to electrons injecting and transporting from the cathode. As a result, these novel copolymers present expected good electroluminescence(EL) performance in their single layer polymer light‐emitting device (PLED) with configuration of ITO/polymer/Al, which turn‐on voltages are between 4.0 and 5.8 V and emit bright green–yellow (538 nm) and yellow (545–552 nm) EL light. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Supervisory control based on closed‐loop adaptive control approach of nonlinear systems: application to CSTR process
Authors: Lehouche H. , Guéguen H. , Mendil B. 
Published: January 2011

AbstractIn the last few years there has been a great deal of interest in the application of adaptive and supervisory control of linear systems using multi‐models and multi‐controllers based on switching and tuning algorithms. In this paper a supervisory control methodology based on a closed‐loop adaptive control approach is developed for nonlinear systems and evaluated in a simulation of a nonlinear continuous stirred tank reactor (CSTR) process for two scenarios according to different set‐point variations. The simulation results show the effectiveness in terms of performance and robustness characteristics of the proposed method.Copyright © 2011 John Wiley and Sons Asia Pte Ltd and Chinese Automatic Control Society
(−)Schisandrin B ameliorates paraquat‐induced oxidative stress by suppressing glutathione depletion and enhancing glutathione recovery in differentiated PC12 cells
Authors: Lam Philip Y. , Ming Ko Kam 
Published: January 2011

AbstractExposure to paraquat (PQ;N,N′‐dimethyl‐4‐4′‐bipyridium), a potent herbicide, can lead to neuronal cell death and increased risk of Parkinson's disease because of oxidative stress. In this study, we investigated the effect of (−)schisandrin B [(−)Sch B, a potent enantiomer of schisandrin B] on PQ‐induced cell injury in differentiated pheochromocytoma cells (PC12). PQ treatment caused cell injury in PC12 cells, as indicated by the significant increase in lactate dehydrogenase (LDH) leakage. Pretreatment with (−)Sch B (5 μM) protected against PQ‐induced toxicity in PC12 cells, as evidenced by the significant decrease in LDH leakage. (−)Sch B induced the cytochromeP‐450‐mediated reactive oxygen species generation in differentiated PC12 cells. The cytoprotection afforded by (−)Sch B pretreatment was associated with an increase in cellular reduced glutathione (GSH) level as well as the enhancement of γ‐glutamylcysteine ligase (GCL) and glutathione reductase (GR) activity in PQ‐challenged cells. Both GCL and GR inhibitors abrogated the cytoprotective effect of (−)Sch B in PQ‐challenged cells. The biochemical mechanism underlying the GSH‐enhancing effect of (−)Sch B was further investigated in PC12 cells subjected to an acute peroxide challenge. Although the initial GSH depletion induced by peroxide was reduced through GR‐catalyzed regeneration of GSH in (−)Sch B‐pretreated cells, the later enhanced GSH recovery was mainly mediated by GCL‐catalyzed GSH synthesis. The results suggest that (−)Sch B treatment may increase the resistance of dopaminergic cells against PQ‐induced oxidative stress through reducing the extent of oxidant‐induced GSH depletion and enhancing the subsequent GSH recovery.
Impact of diabetes mellitus status on coronary pathoanatomy and interventional treatment: Insights from the Euro heart survey PCI registry
Authors: Bauer Timm , Möllmann Helge , Weidinger Franz , Zeymer Uwe , Seabra‐Gomes Ricardo , Eberli Franz , Serruys Patrick , Vahanian Alec , Silber Sigmund , Wijns William , Hochadel Matthias , Nef Holger M. , Hamm Christian W. , Marco Jean , Gitt Anselm K. 
Published: January 2011

AbstractObjectives: The present analysis was performed to evaluate the impact of diabetes mellitus (DM) status on the severity of coronary artery disease (CAD) and current approaches in interventional treatment. Background: Little is known about the effect of DM treated with diet, oral agents, or insulin on lesion characteristics and anatomical pattern of CAD and their interventional treatment. Methods and results: Patients (n = 46,779) of the contemporary Euro Heart Survey PCI registry with known DM status were included in this analysis. Nondiabetics (n = 35,280, 75.4%) were compared with diabetics treated with diet (n = 1,533, 3.3%), oral agents (n = 7,222, 15.4%), and insulin (n = 2,744, 5.8%). Diabetic patients were older, suffered more frequently from comorbidities and presented more often with cardiogenic shock. The number of severely stenosed (≥70%) segments incrementally increased from nondiabetics to insulin‐requiring diabetics. The location of lesions did not differ between patients with and without DM. The ratio stenosed/treated segments progressively rose among the four patient cohorts. The severity of DM negatively correlated with the extent of complete revascularization. After adjustment for confounding variables no significant differences in hospital mortality could be observed between patients without DM and diabetics treated with diet, but a significantly higher rate of death was seen in diabetic patients with oral medication and insulin therapy. Conclusions: Although CAD was more severe in patients with DM the percentage of treated segments with ≥70% stenosis was lower. Adjusted hospital mortality was increased among diabetics treated with oral medication or insulin, but not among those treated with diet. © 2011 Wiley‐Liss, Inc.
Comparison of closure strategies after balloon aortic valvuloplasty: Suture mediated versus collagen based versus manual
Authors: Ben‐dor Itsik , Looser Patrick , Bernardo Nelson , Maluenda Gabriel , Torguson Rebecca , Xue Zhenyi , Lindsay Joseph , Pichard Augusto D. , Satler Lowell F. , Waksman, Ron 
Published: January 2011

AbstractObjectives: To compare complication rates of a collagen‐mediated closure device, suture‐mediated closure technique and manual compression for access site management following balloon aortic valvuloplasty (BAV). Background: Vascular complications, including perforation, limb ischemia, ateriovenous fistulas, and pseudoaneurysm, are a common source of morbidity in patients undergoing BAV with large bore femoral artery access. The available options for closure of the access site include manual compression, suture‐mediated closure devices, and recently reported collagen‐based closure devices. Methods: The study cohort consisted of 333 patients with severe aortic stenosis undergoing BAV. Patients were divided into four groups according to access closure method: (1) Manual compression in 64 (19.2%); (2) Proglide 6 Fr in 162 (48.6%); (3) Angio‐Seal 8 Fr in 89 (26.75%); and (4) Prostar 10 Fr in18 (5.4%). Results: There were no significant differences in baseline characteristics among the groups; although the Prostar group was had more males and the Angio‐Seal group reported a lower incidence of renal failure and peripheral vascular disease. The Angio‐Seal group had shorter procedural duration times compared with the other groups. In the Angio‐Seal group (n = 47, 52.8%), a 10 Fr sheath size was primarily used to access the femoral artery, as compared with the manual compression and Proglide groups, which used a 12 Fr sheath in 29 (45.3%) and 66 patients (40.7%), respectively. A 13 Fr sheath was used in the Prostar group (n = 11, 61.1%), P < 0.001. The device failure rate was significantly higher in the Proglide group (n = 20, 12.3%) as compared with Angio‐Seal (n = 3, 3.3%) and Prostar groups (n = 1, 5.5%), P = 0.03. Serious vascular complications requiring intervention were significantly higher in the manual compression group (n = 11, 17.1%) compared with the Proglide (n = 11, 6.7%), Angio‐Seal (n = 5, 5.6%), and Prostar groups (n = 5, 1%), P < 0.001. The requirement for blood transfusion in the Angio‐Seal group was significantly lower (n = 7, 7.8%) as compared with the manual compression (n = 20, 31.2%), Proglide (n = 35, 21.6%), and Prostar groups (n = 5, 27.7%), P < 0.001. Conclusion: In our case series, collagen‐based closure devices and suture‐mediated closure devices had fewer vascular complications than manual compression for hemostasis following BAV. Patient selection for collagen‐based versus suture‐mediated closure requires further study. © 2011 Wiley‐Liss, Inc.
Catheter closure of atrial septal defect in anatomically corrected malposition with left juxtaposition of the atrial appendages using intracardiac echocardiography
Authors: Bendaly Edgard A. , Hoyer Mark H. 
Published: January 2011

AbstractAnatomically corrected malposition is characterized by abnormally related great vessels and atrioventricular and ventriculoarterial concordance. It is often associated with juxtaposition of the atrial appendages where the plane of the atrial septum is abnormally oriented. We describe the device closure of an atrial septal defect in a patient with such a lesion under intracardiac echocardiography guidance. © 2011 Wiley‐Liss, Inc.
ChemInform Abstract: High Conductivity in Hydrothermally Grown AgCuO2 Single Crystals Verified Using Focused‐Ion‐Beam‐Deposited Nanocontacts.
Authors: Munoz‐Rojas David , Cordoba Rosa , Fernandez‐Pacheco Amalio , De Teresa Jose Maria , Sauthier Guillaume , Fraxedas Jordi , Walton Richard I. , Casan‐Pastor Nieves 
Published: January 2011

AbstractUnprecedented large AgCuO2 single crystals are hydrothermally synthesized from a mixture of Ag2Cu2O3, KOH, K2S2O8, and H2O (autoclave, 90 °C, 20 h).
ChemInform Abstract: Structural, Magnetic and Dielectric Properties of La2‐xCaxNiO4+δ (x = 0, 0.1, 0.2, 0.3).
Authors: Shi Chen‐Yang , Hu Zhong‐Bo , Hao Yong‐Mei 
Published: January 2011

AbstractThe title compounds are prepared by solid state reaction of La2O3, CaCO3, and NiO (1000, 1100, and 1200 °C for 12 h each, followed by sintering at 1300 °C for 24 h).
ChemInform Abstract: Synthesis and Thermal Stability of Cubic ZnO in the Salt Nanocomposites.
Authors: Sokolov P. S. , Baranov A. N. , Dobrokhotova Zh. V. , Solozhenko V. L. 
Published: January 2011

AbstractMetastable cubic ZnO is synthesized from monodispersed nanoparticles of wurtzite ZnO in the presence of NaCl under a pressure of 7.7 GPa (700—900 K, 15 min).
ChemInform Abstract: Giant Crown‐Shaped Polytungstate Formed by Self‐Assembly of CeIII‐Stabilized Dilacunary Keggin Fragments.
Authors: Reinoso Santiago , Gimenez‐Marques Monica , Galan‐Mascaros Jose Ramon , Vitoria Pablo , Gutierrez‐Zorrilla Juan M. 
Published: January 2011

AbstractSingle crystals of Na40K6[Ni(H2O)6]3 [K@K7Ce24Ge12W120O456 (OH)12(H2O)64]· 178H2O are synthesized by addition of KCl to a NaOAc/AcOH buffer solution containing Ce(NO3)3, GeO2, Na2WO4, and NiCl2 followed by slow evaporation at room temperature (24% yield).
ChemInform Abstract: Synthesis, Crystal Structure and Characterization of an Organically Templated Cobalt Phosphate Supramolecule.
Authors: You Xiaoyan , Zhu Lixia 
Published: January 2011

AbstractPink plane‐like single crystals of (H2en)2 [Co(H2O)6]2(HPO4)4 are hydrothermally synthesized from aqueous solutions of CoCl2, H3PO4, and en (autoclave, pH 4, 170 °C, 2 d).
ChemInform Abstract: Complex Alloys Containing Double‐Mackay Clusters and (Sb1‐δZnδ)24 Snub Cubes Filled with Highly Disordered Zinc Aggregates: Synthesis, Structures, and Physical Properties of Ruthenium Zinc Antimonides.
Authors: Xiong Ding‐Bang , Zhao Yufeng , Schnelle Walter , Okamoto Norihiko L. , Inui Haruyuki 
Published: January 2011

AbstractRu26Sb24Zn67 (I), Ru13Sb12Zn83.4 (II), Ru13Sb6.29Zn91.56 (III), and Ru13Sb17.1Zn74.9 (IV) alloys are synthesized from the elements (823—873 K, 3—5 d) and their crystal structures are determined by single crystal XRD.
ChemInform Abstract: Asymmetric Allylation of Aldehydes Catalyzed by Simple Dual Small Organic Molecules: L‐Proline and L‐Prolinol.
Authors: Chen Guo‐hong , Liu Ling‐yan , Wei Xiao‐ning , Chang Wei‐xing , Li Jing 
Published: January 2011

AbstractA novel and simple protocol for the asymmetric allylation of aldehydes is developed.
ChemInform Abstract: Stereoselective Synthesis of Vinyl‐Substituted (Z)‐Stilbenes by Rhodium‐Catalyzed Addition of Arylboronic Acids to Allenic Alcohols.
Authors: Miura Tomoya , Shimizu Hiroshi , Igarashi Tomohiro , Murakami Masahiro 
Published: January 2011

AbstractThe stereochemical outcome of the reaction is opposite to that of the corresponding reaction of (I) and (II) using a palladium catalyst which selectively produces (E)‐isomers.
ChemInform Abstract: A Facile and Divergent Synthesis of Substituted Pyridine‐2,4(1H,3H)‐diones and 4H‐Thiopyran‐4‐ones from α‐Alkenoyl‐α‐carbamoyl Ketene‐S,S‐acetals.
Authors: Liu Jinying , Fu Xiaolan , Zhou Yang , Zhou Guangyuan , Liang Yongjiu , Dong Dewn 
Published: January 2011

AbstractTitle pyridinediones (II) are successfully synthesized by heating α‐dimethylaminopropenoyl‐α‐carbamoyl ketene‐S,S‐acetals (I) in DMF at 125°C.