bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chloride intracellular channel 1 identified using proteomic analysis plays an important role in the radiosensitivity of HEp‐2 cells via reactive oxygen species production
Authors: Kim Jae‐Sung , Chang Jong Wook , Yun Hong Shik , Yang Kyung Mi , Hong Eun‐Hee , Kim Dong Hyun , Um Hong‐Duck , Lee Kee‐Ho , Lee Su‐Jae , Hwang Sang‐Gu 
Published: May 2010

AbstractThe nature of the molecules underlying the radioresistance phenotype of laryngeal cancer cells remains to be established. We initially generated radioresistant laryngeal cancer cell lines from human HEp‐2 cells with fractionated radiation. These RR‐HEp‐2 cells and isolated clones displayed more radioresistant and anti‐apoptotic phenotypes than parental HEp‐2 cells after radiation. Characteristics of RR‐Hep‐2 cell lines were confirmed by upregulation of radioresistance‐related genes, such as epidermal growth factor receptor, Hsp90, and Bcl‐xl. Subsequently, we examined proteome changes between HEp‐2 and RR‐HEp‐2 cells and identified 16 proteins showing significantly altered expression levels. Interestingly, protein expression of chloride intracellular channel 1 (CLIC1) was markedly suppressed in RR‐HEp‐2 cells, compared with non‐irradiated control cells. Suppression of CLIC1 with an indanyloxyacetic acid‐94 or small interfering RNA led to radioresistance in HEp‐2 cells by suppressing the radiation‐induced cellular ROS level. However, ectopic overexpression of CLIC1 induced radiosensitivity in RR‐HEp‐2 cells via induction of ROS level after radiation, suggesting that the protein acts as a positive regulator of ROS production. Our results collectively indicate that suppression of CLIC1 contributes to acquisition of the radioresistance phenotype of laryngeal cancer cells via inhibition of ROS production, implying that this protein is an important candidate molecule for radiotherapy in radioresistant laryngeal cancer cells.
Psychological distress among family carers of oesophageal cancer survivors: the role of illness cognitions and coping
Authors: Dempster Martin , McCorry Noleen K. , Brennan Emma , Donnelly Michael , Murray Liam J. , Johnston Brian T. 
Published: May 2010

AbstractObjective: The research aimed to determine the extent to which illness cognitions and coping explain psychological distress (fear of cancer recurrence, anxiety and depression symptoms) among family carers of survivors of oesophageal cancer.Methods: Carers of patients registered with the Oesophageal Patients' Association in the UK were mailed a questionnaire booklet containing questions about medical and demographic variables, the Illness Perception Questionnaire‐Revised, the Cancer Coping Questionnaire, the Concerns about Recurrence Scale and the Hospital Anxiety and Depression Scale.Results: Complete responses were received from 382 family carers (75% male; mean (SD) age=62 (10.91) years). Regression models indicated that the variables measured could explain between 35 and 49% of the variance in psychological distress among carers. Illness cognitions (particularly perceptions of the cause of, consequences of and personal control over oesophageal cancer and the carer's understanding of the condition) explained the majority of this variance. Positive focus coping strategies were also found to be important in explaining psychological distress.Conclusion: The results of this study are consistent with previous research demonstrating that illness cognitions are significant correlates of adaptive outcomes, thereby suggesting that cognition‐based interventions could potentially be effective in minimizing emotional distress among family carers of oesophageal cancer survivors. Copyright © 2010 John Wiley & Sons, Ltd.
Functionalization of Nonwoven Pet Fabrics by Water/O2 Plasma for Biomolecule Mediated Cell Cultivation
Authors: Sasmazel Hilal Turkoglu , Manolache Sorin , Gümüşderelioğlu Menemşe 
Published: May 2010

AbstractThe main target of this study was to obtain COOH functionalities on the surface of 3D, nonwoven polyethylene terephthalate fabrics (NWPFs) by using low pressure water/O2 plasma assisted treatment. The plasma treatments were performed in a cylindrical, capacitively coupled RF‐plasma‐reactor and then following steps were performed: in situ (oxalyl chloride vapors) gas/solid reaction to convert OH functionalities into COCl groups; and hydrolysis under open laboratory conditions using air moisture for finalCOOH functionalities. COOH and OH functionalities on the surfaces were detected quantitatively by fluorescent labeling techniques. The COOH‐functionalized samples were biologically activated with insulin or heparin molecules by using spacer polyoxyethylene bis‐amine (PEO). Successful immobilization was checked qualitatively using electron spectroscopy for chemical analysis (ESCA). The average amount of immobilized insulin and heparin onto NWPF surfaces were determined as 146.09 and 4.81 nmol · cm−2, respectively. Our results showed that water/O2 plasma assisted treatment worked very well for functionalization and biofunctionalization of 3D NWPF disks comparing with wet‐chemistry methods. Cell culture experiments indicated that functionalization of NWPF disks and/or nanotopographies on the disk surfaces were effective on adhesion and proliferation of L929 mouse fibroblasts.magnified image
Crystal structure of Bacillus subtilis SPP1 phage gp22 shares fold similarity with a domain of lactococcal phage p2 RBP
Authors: Veesler David , Blangy Stéphanie , Spinelli Silvia , Tavares Paulo , Campanacci Valérie , Cambillau Christian 
Published: May 2010

AbstractSPP1 is a siphophage infecting the gram‐positive bacterium Bacillus subtilis. It is constituted by an icosahedric head and a long non‐contractile tail formed by gene products (gp) 17–21. A group of 5 small genes (gp 22–24.1) follows in the genome those coding for the main tail components. However, the belonging of the corresponding gp to the tail or to other parts of the phage is not documented. Among these, gp22 lacks sequence identity to any known protein. We report here the gp22 structure solved by X‐ray crystallography at 2.35 Å resolution. We found that gp22 is a monomer in solution and possesses a significant structural similarity with lactococcal phage p2 ORF 18 N‐terminal “shoulder” domain.
Near‐UV LEDs for integrated InO‐based ozone sensors
Authors: Wang Ch. Y. , Cimalla V. , Kunzer M. , Passow T. , Pletschen W. , Kappeler O. , Wagner J. , Ambacher O. 
Published: May 2010

AbstractThe paper reports on the integration of resistive gas sensors from indium oxide nanoparticles with near‐ultraviolet light emitting diodes (LEDs) for miniaturized and highly sensitive ozone sensing. For the integrated sensor an LED with an optical power as low as 250 μW is sufficient. An optimum operational window of the LED wavelength is determined to be between 380–420 nm. Furthermore, two operational modes of the used LED (pulse and continuous modes) have been compared and it is found that the pulse mode is more suitable for real applications. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
MOVPE growth of high optical quality InGaPN layers on GaAs (001) substrates
Authors: Kaewket Dares , Sanorpim Sakuntam , Tungasmita Sukkaneste , Katayama Ryuji , Onabe Kentaro 
Published: May 2010

AbstractHighly luminescent In0.528Ga0.472P1‐yNy layers (y =0–0.027) were grown on GaAs (001) substrates by metalorganic vapor phase epitaxy. The dependence of photoluminescence (PL) properties on the N content in In0.528Ga0.472P1‐yNy layers was investigated. Near‐band edge emissions were obviously observed up to room temperature. With increasing temperature, the PL peak energy exhibits an inverted S‐shape, which explained by the strong localization of carriers at low‐temperatures, while the band‐to‐band transition becomes dominant at higher temperatures. With incorporation of N into In0.528Ga0.472P, the bandgap at 10 K is red‐shifted as large as 110 meV for the highest N‐containing layer (y =0.027), indicating a large bandgap bowing. Further, the temperature dependence of the bandgap energy becomes significantly weak with increasing N content. Our results suggest that the density of states around the band edge of In0.528Ga0.472P1‐yNy is modified from that of In0.528Ga0.472P due to the localized states possibly induced by the presence of N. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Very low sheet resistance AlInN/GaN HEMT grown on 100 mm Si(111) by MOVPE
Authors: Cheng Kai , Degroote S. , Leys M. , Medjdoub F. , Derluyn J. , Sijmus B. , Germain M. , Borghs G. 
Published: May 2010

AbstractThis paper presents results on the properties of AlInN/GaN high electron mobility transistors (HEMT) grown on 100 mm Si(111) substrates by metal organic vapour phase epitaxy (MOVPE). To the best of our knowledge this is the first demonstration of AlInN/GaN HEMT with a very low sheet resistance of 179 ± 3.9 Ω/□ on large size Si substrates. The electron density of the two dimensional electron gas (2DEG) is as high as 3.1×1013/cm2, while the electron mobility is around 1000 cm2/Vs. The very low sheet resistance of AlInN/GaN HEMT results in a high current density of 1.3 A/mm in device operation with a gate length of 1.5 μm. The current density of the AlInN/GaN HEMT is twice as high as our standard AlGaN/GaN HEMT with the same geometry, which shows a great potential for high power switching applications. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
High‐performance GaN/InGaN heterojunction bipolar transistors using a direct‐growth approach
Authors: Lee Yi‐Che , Kim Hee‐Jin , Zhang Yun , Choi Suk , Dupuis Russell D. , Ryou Jae‐Hyun , Shen Shyh‐Chiang 
Published: May 2010

AbstractWe report high performance npn GaN/InGaN double heterojunction bipolar transistors (DHBTs) that was directly grown on sapphire substrates with high common‐emitter current gain (>40) at collector current density (JC) > 5 kA/cm2. A study on the emitter sizing effect shows that the perimeter‐dependent recombination current density changes from 1.5×10‐6 to 6.1×10‐4 A/cm as JC increases from 5 A/cm2 to 100 A/cm2. The fabricated multi‐fingered DHBTs show similar surface recombination current density and a current gain of > 23 at JC > 100 A/cm2 is also achieved (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
AlGaN‐based 330 nm resonant‐cavity‐enhanced p–i–n junction ultraviolet photodetectors using AlN/AlGaN distributed Bragg reflectors
Authors: Xie Zili , Liu Bin , Nie Chao , Jiang Ruolian , Ji Xiaoli , Zhao Hong , Han Ping , Xiu Xiangqian , Zhang Rong , Zheng Youdou , Gong Haimei 
Published: May 2010

AbstractAlGaN‐based resonant‐cavity‐enhanced (RCE) p‐i‐n junction photodetectors (PDs) operating at the wavelength of 330 nm are fabricated by metal organic chemical vapor deposition (MOCVD). The growth and characterization of AlN/Al0.3Ga0.7N distributed Bragg reflectors(DBRs) are investigated firstly. It is shown that with increasing the pairs of the bi‐layers, the reflectance of AlN/AlGaN DBR is elevated, but the stop band width is depressed. For grown RCE PDs structure, a 20.5‐pair AlN/Al0.3Ga0.7N DBR is selected as the back mirror and 3‐pair AlN/Al0.3Ga0.7N DBR as the front one to form an optical micro‐cavity. A p‐GaN/i‐GaN/n‐Al0.3Ga0.7N junction structure is used as active layers within the cavity. The optical absorption of the RCE PD structure is approximately 59.8% determined by reflectance measurement. Selectively enhanced by the cavity effect, a response peak of 0.128 A/W at 330 nm with external quantum efficiency of 48% is obtained under zero bias. The peak wavelength shifted 15 nm with the incident angle of light increasing from 0° to 60°, which suggests that the detection wavelength can be tuned by controlling the angle of incoming light (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Resonating valence‐bond mechanism for the superconductivity in K3C60
Authors: Bastos Cristiano C. , Costa Marconi B. S. , Pavão Antonio C. 
Published: May 2010

AbstractDensity functional theory calculations in different cluster models, the largest one K38(C60)23 with 1,418 atoms, combined with the resonating valence‐bond theory show that superconductivity in K3C60 involves interaction of C60 with K+, K0, and K− in octahedral interstices as well as immobilization of negative charges on positive tetrahedral K atoms. We found that the orbitals involved in the highest occupied molecular orbital–lowest unoccupied molecular orbital gap are mainly from C60 and octahedral potassium atoms. We suggest that a K3C60 superconductor improvement can be achieved through potassium atom vacancy in octahedral sites. © 2010 Wiley Periodicals, Inc. Int J Quantum Chem, 2010
Resilient decentralized stabilization of interconnected time‐delay systems with polytopic uncertainties
Authors: Mahmoud Magdi S. , Almutairi Naif B. 
Published: May 2010

AbstractDecentralized delay‐dependent local stability and resilient feedback stabilization methods are developed for a class of linear interconnected continuous‐time systems. The subsystems are time‐delay plants which are subjected to convex‐bounded parametric uncertainties and additive feedback gain perturbations while allowing time‐varying delays to occur within the local subsystems and across the interconnections. The delay‐dependent local stability conditions are established at the subsystem level through the construction of appropriate Lyapunov–Krasovskii functional. We characterize decentralized linear matrix inequalities (LMIs)‐based delay‐dependent stability conditions by deploying an injection procedure such that every local subsystem is delay‐dependent robustly asymptotically stable with an γ‐level ℒ︁2‐gain. Resilient decentralized state‐feedback stabilization schemes are designed, which takes into account additive gain perturbations such that the family of closed‐loop feedback subsystems enjoys the delay‐dependent asymptotic stability with a prescribed γ‐level ℒ︁2‐gain for each subsystem. The decentralized feedback gains are determined by convex optimization over LMIs. All the developed results are tested on representative examples. Copyright © 2010 John Wiley & Sons, Ltd.
Factors affecting stranding of juvenile salmonids by wakes from ship passage in the Lower Columbia River
Authors: Pearson W. H. , Skalski J. R. 
Published: May 2010

AbstractThe effects of deep‐draft vessel traffic in confined riverine channels on shorelines and fish are of widespread concern. In the Pacific Northwest of the United States, wakes and subsequent beach run‐up from ships transiting the Lower Columbia River have been observed to strand juvenile salmon and other fish. As part of a before‐and‐after study to assess stranding effects that may be associated with channel deepening, we measured 19 variables from observations of 126 vessel passages at three low‐slope beaches and used multiple logistic regression to discern the significant factors influencing the frequency of stranding. Subyearling Chinook salmon were 82% of the fish stranded over all sites and seasons. Given a low‐slope beach, stranding frequencies for juvenile salmon were significantly related to river location, salmon density in the shallows, a proxy for ship kinetic energy, tidal height and two interactions. The beach types selected for our study do not include all the beach types along the Lower Columbia River so that the stranding probabilities described here cannot be extrapolated river‐wide. A more sophisticated modelling effort, informed by additional field data, is needed to assess salmon losses by stranding for the entire lower river. Such modelling needs to include river‐scale factors such as beach type, berms, proximity to navigation channel, and perhaps, proximity to tributaries that act as sources of outmigrating juvenile salmon. At both river and beach scales, no one factor produces stranding; rather interactions among several conditions produce a stranding event and give stranding its episodic nature. Published in 2010 by John Wiley & Sons, Ltd.
An in situ temperature‐programmed XPS study of the surface chemical reactions of thiophene with Ag/titania
Authors: Samokhvalov Alexander , Duin Eduardus C. , Nair Sachin , Tatarchuk Bruce J. 
Published: May 2010

AbstractThe Ag/titania sorbent for the ultradeep desulfurization of liquid fuels was characterized by electron spin resonance and was found to contain nearly the stoichiometric titania, without significant concentration of Ti3+ or the reactive oxygen species. The surface chemical reactions of thiophene adsorbed on the Ag/titania were studied by temperature‐programmed XPS from 25 to 525 °C upon in situ thermal annealing in high vacuum and in situ oxidation by oxygen gas. The titania support is not chemically reactive under those conditions. Silver oxide in the Ag/titania sorbent is converted to Ag2 S without formation of the transient surface sulfates or sulfites and is further oxidized by molecular oxygen. Copyright © 2010 John Wiley & Sons, Ltd.
Grafting of polyethylene glycols onto nanometer silica surface by 1,4‐phenylene diisocyanate
Authors: Zhang Wentao , Lee Hong‐Ro 
Published: May 2010

AbstractIn this paper, polyethylene glycol (PEG) molecules have been grafted onto the surface of nanometer silica in toluene by using 1,4‐phenylene diisocyanate (PPDI) as a coupling agent, and dibutyltion dilaurate (DBTDL) as a catalyst. This process was executed by using a one‐step procedure involving a first reaction of PPDI with silica and a subsequent reaction of isocyanate‐bound silica with PEG. The PEG‐grafted silica has been characterized by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and SEM analyses. The effects of reaction time, temperature and molar ratio of reactant on the effectiveness of the surface grafting were also investigated. Optimum grafting conditions of PEG were obtained at the temperature of 80 °C for 8 h. Maximum grafting of PEG molecules ratio was 22.6%, and maximum overall grafting ratio was 35%, as determined by TGA. Copyright © 2010 John Wiley & Sons, Ltd.
Surface studies of diamond‐like carbon films grown by plasma‐enhanced chemical vapor deposition
Authors: Maheswaran R. , Sivaraman R. , Mahapatra O. , Rao P. C. , Gopalakrishnan C. , Thiruvadigal D. J. 
Published: May 2010

AbstractThe influence of plasma pressure on the surface morphology of diamond‐like carbon (DLC) films, synthesized by plasma enhanced chemical vapour deposition (PECVD) has been investigated. The DLC films have been grown at different methane–argon ratios. The grain size and the surface roughness have been studied as a function of plasma pressure. The morphology and surface roughness of the films have been inspected by atomic force microscopy. The film surface has also been characterized by Raman spectroscopy to study the hybridization of carbon in the film so as to evaluate its carbon composition. The results confirm that the film grown at low argon pressure has more uniform distribution on the substrate. The Raman spectrum indicates that increase in plasma pressure leads to a proportional increase in the amount of sp3 hybridized carbon in the grown film. Copyright © 2010 John Wiley & Sons, Ltd.
Probing chemical homogeneity within single cluster impact sites
Authors: Pinnick Veronica , Verkhoturov Stanislav V. , Kaledin Leonid , Schweikert Emile A. 
Published: May 2010

AbstractWe have recently reported a nanoprobe technique based on time‐of‐flight secondary ion mass spectrometry (ToF‐SIMS) capable of obtaining molecular information from individual nanoobjects. The technique is based on event‐by‐event bombardment/detection, where information from individual objects is obtained via coincidental secondary ion emission from single projectile impacts. Here, we demonstrate that the event‐by‐event mode is sensitive to the chemical and/or physical separation of molecular species. As a test case, two nanoobject samples with the same chemical composition were prepared with different morphologies. Both consisted of polystyrene spheres deposited onto nanoalumina whiskers, but their structures differed. One sample contained 30 nm spheres intact, and the other produced nanoflake structures. Bombardment with Au4004+ at 136 keV total impact energy demonstrates that conventional mass spectra do not reflect differences between the morphologies, whereas the coincidental mass spectra show significant differences in coemission of aluminum‐based and carbon‐based secondary ions. Copyright © 2010 John Wiley & Sons, Ltd.
Failure analysis of fine Cu patterning by shave‐off profiling
Authors: Nojima M. , Fujii M. , Kakuhara Y. , Tsuchiya H. , Kameyama A. , Yokogawa S. , Owari M. , Nihei Y. 
Published: May 2010

AbstractWe focused on failure within fine copper patterning on a semiconductor chip. Three grades of samples were prepared; hard CMP treatment, soft CMP treatment and standard, and compared the differences by shave‐off profiling. The shave‐off profiles of CMP treatment revealed a saw‐toothed structure, and the shave‐off profile of a standard chip was revealed as a periodic triangular wave. The difference can be explained by the existence of residue on the CMP process. Copyright © 2010 John Wiley & Sons, Ltd.
Sputtering soft materials with molecular projectiles: a microscopic view
Authors: Delcorte A. , Garrison B. J. , Hamraoui K. 
Published: May 2010

AbstractThe sputtering of bulk organic samples by molecular projectiles is modeled using molecular dynamics simulations. A coarse‐grained representation of entangled polyethylene oligomers (1.4 kDa) is used as a model of an amorphous soft material. In this study, a variety of projectiles are compared, including C60, coronene and a series of polystyrene molecular cluster (0.6–110 kDa). The polystyrene clusters bridge the gap between the polyatomic ions (SF5, C60) used in secondary ion mass spectrometry (SIMS) and the large organic microdroplets generated, e.g. in desorption electrospray ionization. In addition, they allow us to explore a wide range of energies/nucleon (0.1–18 eV/nucleon) with projectiles of similar nature and the same total kinetic energy (10 keV). Two regions of sputtering can be distinguished. Above 1 eV/nucleon (smaller projectiles), the sputtering yield depends only on the total projectile energy and not on the projectile nuclearity. Below 1 eV/nucleon (larger projectiles), yields are influenced by both the projectile energy and their nuclearity. Larger projectiles also eject fewer fragments and induce significantly less damage in the sample. A region of intact molecular emission, without induced fragmentation, exists in the < 1 eV/nucleon range. For large clusters, an energy of < 1 eV/nucleon still provides a sputtered mass from the target that is larger than 10 kDa. This region of molecular emission with minimal fragmentation, also attainable with large gas clusters, offers new analytical perspectives. Copyright © 2010 John Wiley & Sons, Ltd.
ToF‐SIMS characterization of the lipid layer on the hair surface. I: the damage caused by chemical treatments and UV radiation
Authors: Habe Taichi , Tanji Noriyuki , Inoue Shigeto , Okamoto Masayuki , Tokunaga Shinichi , Tanamachi Hiroto 
Published: May 2010

AbstractIn this study, we investigated how the lipids bound to the outermost surface of human hair are affected by chemical treatments such as hair bleach and ultraviolet (UV) radiation using time‐of‐flight secondary ion mass spectrometry (ToF‐SIMS). Many lipid components are bound covalently via a thioester or ester linkage on the outermost surface of hair. We studied how these components are changed by chemical treatment. It was found that the fatty acids covalently bound via a thioester linkage are removed more easily than those with an ester linkage. Eighty percent of the 18‐MEA (18‐methyleicosanoic acid), which is a major component of lipids, was removed in a single bleach treatment, and most had vanished entirely after three treatments. We also investigated the influence of UV radiation and found that the amount of 18‐MEA decreased with the radiation time. More than 90% of the 18‐MEA was removed by UV radiation with corresponding exposure of three summer months. Copyright © 2010 John Wiley & Sons, Ltd.