bluuebunny/crossref_metadata_2025_split huggingface dataset:
A dual‐mode integration framework and application to agile feedback design of launch vehicles
Authors: Zhang Wenfeng , Cai Xiaoshuang , Liu Zhendong , Luo Shan , Yu Rendong 
Published: June 2024

AbstractIn recent decades, the design of complex systems like launch vehicles in the aerospace industry has presented engineers with challenges that go beyond system complexity. Issues such as time‐to‐market pressures and intricate industrial processes have underscored the increasing significance of agile design methodologies. Agile design is derived from the simplification of the design process and enhancing cross‐domain data transmission and feedback. While methods based on model‐based system engineering have improved iteration times in system architecture design, challenges persist in cross‐domain data transmission. Due to the diversity of complex system models and data, a single‐mode integration method is difficult to realize the data link construction of all tools used. To address this challenge, this paper proposes a dual‐mode data integration framework with expansibility, universality, and cost‐efficiency which leverages the benefits of Remote Procedure Call and Intermediate Exchange Module, addressing the challenge of constructing cross‐domain data links under single‐mode integration. In this study, two critical requirements of the first‐ and second‐stage separation systems, namely, weight and minimum separation gap, are selected for data feedback. A Modelica‐based multiphysics simulation model is developed in MWorks; visualization and computation of the minimum gap are carried out in CoppeliaSim. To bridge the gap between domain‐specific tools, Matlab and Functional Mock‐up Unit modules are introduced as middleware, facilitating data feedback linkage. The entire simulation process is orchestrated using activity diagrams in the MagicDraw tool. The study delves into the influence of critical design parameters, such as the initial angular velocity of separation and the thrust of the retro rocket, on the minimum separation gap. It provides an analysis of minimum separation gap variations under uncertain operating conditions and examines design margins. Significantly, the paper highlights the significance of controlling the initial angular velocity during separation and the reliability of the retro rocket, providing essential decision supports and valuable insights to agile the process of system design.
Resilience in children of parents with mental illness, alcohol or substance misuse—An integrative review
Authors: Ahlborg Mikael Gunnar , Nygren Jens Martin , Svedberg Petra , Regber Susann 
Published: June 2024

AbstractAimThe aim of this integrative review was to investigate how resilience has been researched and explore experiences of resilience, in children of parents with mental illness or alcohol or substance misuse.DesignAn integrative review.MethodThe search included three major electronic databases, PubMed, Scopus and PsycINFO with the aim of identifying peer‐reviewed studies where the concept of resilience was explored as resilience, coping, adaptation or protective factors.ResultsOut of 4016 studies, 14 were included after meeting predetermined criteria and methodological quality evaluation. The findings are presented in five categories: characteristics of the studies, operationalization and interpretation of resilience, individual resources, family resources and resources outside the family.Patient or public contributionResilience in children of parents with mental illness or substance misuse refers to coping strategies, protective factors and absence of symptoms or risk behaviour despite being exposed to risk. We suggest a three‐level approach for mapping of resilience resources in the target group: the individual level, family level and outside of the family that includes both non‐professionals and professionals. The use of disengagement or avoidance strategies implies poor resilience but may be necessary in absence of support, as acts of self‐preservation during chaotic periods or harmful situations.
The Complications of Osseous Reconstruction in the Head and Neck: A Systematic Review and Meta‐analysis
Authors: Khan Usman , Hathi Kalpesh , MacKay Colin , Corsten Martin 
Published: June 2024

AbstractObjectiveTo compare the postoperative complications of the fibular free flap (FFF), scapula free flap (SFF), and osteocutaneous radial forearm free flap (OCRFFF) following osseous reconstruction in the head and neck.Data SourcesPUBMED, EMBASE, Cochrane.Review MethodsA literature search and systematic review were performed using the Preferred Reporting Items for Systematic Reviews and Meta‐analysis guidelines. A meta‐analysis of proportions was conducted using a random effects model to compare operative time and postoperative complications.ResultsThe systematic review identified 26 studies comparing at least 1 variable of interest. The odds ratio estimates favored reduced rates of flap failure with the OCRFFF when compared to FFF (0.7, confidence interval [CI]: 0.29‐1.11, P < .001), while FFF and SFF were similar. The mean difference estimates for operative time significantly favored FFF over SFF (−51.04 minutes, CI: −92.73 to −9.35, P = .016) and OCRFFF over FFF (66.77 minutes, CI: 52.74‐80.8, P < .001). The FFF was more prone to hardware exposure, longer hospital stays, and donor site complications. Recipient wound complications and fistula rates were similar for all flap types.ConclusionDepending on the clinical context, the OCRFFF, FFF, and SFF are all robust options for reconstruction in the head and neck. The OCRFFF is associated with a reduced rate of flap failure and shorter operative times. The SFF requires longer operative times, although significant variation was observed between institutions. The FFF has broad reconstructive indications but is associated with more perioperative and long‐term complications.
Pharyngeal Mucosal Margin Vessel Counts Predict Pharyngocutaneous Fistula in Salvage Laryngectomy
Authors: Prince Andrew D.P. , Heft Neal Molly E. , Buchakjian Marisa R. , Chinn Steven B. , Stucken Chaz L. , Casper Keith A. , Malloy Kelly M. , Prince Mark E.P. , Rosko Andrew J. , McHugh Jonathan B. , Spector Matthew E. 
Published: June 2024

AbstractObjectiveWe evaluated vessel counts in the pharyngeal mucosal margins of patients who underwent salvage laryngectomy to establish whether mucosal vascularity might predict fistula risk.Study DesignRetrospective cohort.SettingTertiary Medical Center.MethodsPatients who underwent salvage total laryngectomy at our institution between 1999 and 2015 were identified. Pharyngeal mucosal margins from laryngectomy specimens were evaluated histologically for each patient, and vessel counts were performed on 5 ×10 images. The primary outcome measure was fistula within 30 days of surgery and mean vessel counts were assessed as the principle explanatory variable.ResultsSeventy patients were included and 40% developed a postoperative fistula. There was a large difference in the mean vessel count in patients who did develop fistula (48.6 vessels/×10 field) compared to those who did not (34.7 vessels/×10 field). A receiver operative characteristic curve found that a cutoff value of 33.9 vessels/×10 field provided a sensitivity of 75% and specificity of 62% to predict the likelihood of fistula occurrence (area under the curve = 0.71, 95% confidence interval [CI]: 0.59‐0.83). In a binary logistic regression, patients with vessel counts greater than 33.9 had a 5‐fold increased risk of developing fistula (95% CI: 1.8‐16.45). Histologically, vessels in the pharyngeal mucosa of patients who developed fistulas were more disorganized.ConclusionAfter salvage laryngectomy, patients with higher mean mucosal margin vessel counts are at increased risk of fistula. The mechanism is unknown, but the disorganization of the vasculature may contribute to poor wound healing. Vessel counting may allow for fistula risk stratification and guide postoperative care.
Study on the Mass Spectrometry Cleavage Pattern of Quinolone Antibiotics
Authors: Fan Susu , Lu Hui , Li Chunjian , Cai Meng , Shi Jian 
Published: June 2024

AbstractRationale: Quinolone antibiotics are extensively used clinically for human treatment and in agriculture. However, improper and excessive use can lead to the persistence of quinolone residues in animal tissues, potentially accumulating in the human body and posing health risks. Investigating the correlation between mass spectrometry cleavage patterns and molecular structural features enhances the analytical framework for detecting trace or unknown impurities in quinolones. Methods: To collect data, we employed triple quadrupole linear ion trap mass spectrometry in electrospray positive ion mode. Primary mass spectrometry scanning was utilized to confirm parent ions, while secondary mass spectrometry scanning enabled the observation of fragment ions. The cleavage characteristics and pathways of the compounds were inferred from accurate mass‐to‐charge ratios obtained from both primary and secondary mass spectrometry. Results: Under soft ionization conditions, the compounds generally exhibited characteristic fragment ions of [M+H−H2O]+, [M+H−CO]+, and [M+H−H2O−CO]+. Additionally, subtle variations were observed in each compound due to differences in modifying groups. For instance, upon deacidification, the piperazine ring structure underwent breakage and rearrangement, yielding fragment ion peaks devoid of neutral molecules such as C2H5N, C3H7N, or C4H8N. Notably, compounds featuring a cyclopropyl substituent group at the N‐1 position typically exhibited characteristic fragments resulting from the loss of the cyclopropyl radical (⋅C3H5). Moreover, substituents at the N‐1 and C‐8 positions, when linked to form a six‐membered carbocyclic ring, were prone to cleavage, releasing the neutral C3H6 molecule. Conclusion: Quinolone antibiotics share structural similarities in their parent nuclei, leading to partially similar cleavage pathways. Nevertheless, distinct cleavage patterns emerge due to variations in functional groups. According to the difference of mass spectrometry cleavage patterns, it can provide an identification basis for the measured detection of antibiotics.
Flexible, wearable and sensitive laser‐induced graphene sensors for human health monitoring
Authors: Huang Qiaoling , Dai Xinming , Guo Shuang , Ma Shuning , Zhao Changlin , Su Weiguo 
Published: June 2024

AbstractBio‐compatible strain sensors are indispensable for human monitoring devices, requiring a delicate balance of robustness, flexibility, and sensitivity. However, achieving these attributes concurrently remains a formidable challenge. This article presents a pioneering approach to fabricate three‐dimensional flexible strain sensors using laser‐induced graphene (LIG) on polyimide (PI) substrates. Through a one‐step laser direct writing (LDW) technique, durable LIG/CuSO4 composites with closed‐pore porous structures are synthesized. The integration of copper sulfate within the closed‐cell architecture of LIG establishes a resilient conducting pathway, enhancing sensitivity to deformation under tensile stress. The resulting sensor exhibits exceptional performance in monitoring a wide range of human movements, from vigorous activities to subtle oscillations and physiological signals. Notably, the sensor boasts a remarkable sensing range of up to 25% strain, coupled with a high sensitivity characterized by a gauge factor of approximately 597. Rapid response times of 175 ms and quick recovery times of 200 ms further underscore its efficiency. Moreover, the sensor demonstrates outstanding stability and durability, maintaining consistent performance over 5600 cyclic experiments. This innovative approach represents a significant advancement in bio‐compatible strain sensor technology, offering a versatile solution for diverse monitoring applications.
Feasibility of a clinic‐based, multicomponent hydroxyurea adherence intervention for adolescents and young adults with sickle cell disease
Authors: Murphy Bridget N. , Keenan‐Pfeiffer Mary E. , Lane Adam , Crosby Lori E. , Walsh Kathleen E. 
Published: June 2024

AbstractDespite the effectiveness of hydroxyurea, adherence remains low for adolescents and young adults (AYA) living with sickle cell disease (SCD). This study evaluated the feasibility, acceptability, and initial efficacy of a clinic‐based, multicomponent (e.g., storytelling, problem solving) intervention with 20 AYA living with SCD. Results found that adherence significantly improved from intervention to follow‐up 1 [t(19) = −2.213, p = .039]. AYA also were generally satisfied with the intervention. These findings, although promising, should be replicated on a larger scale.
Tumor budding is a meaningful prognostic marker in patients with hepatocellular carcinoma after curative hepatectomy
Authors: Yang Kaibo , Wu Kunjin , Lei Zitong , Liu Tong , Zhang Xing , Li Jing , Yang Kun , Peng Qiuting , Lin Ting , Liu Chang , Qu Kai 
Published: June 2024

AbstractAimTumor budding (TB) has excellent prognostic value in many solid tumors, but there is little research on it in hepatocellular carcinoma (HCC). This study assessed the prognostic value of TB in patients with HCC who received hepatectomy.MethodsThis retrospective study included 210 patients with HCC who received curative hepatectomy at the First Affiliated Hospital of Xi'an Jiaotong University, between 2016 and 2018. TB was evaluated on hematoxylin‐ and eosin‐stained slides according to the criteria established by the 2016 International Tumor Budding Consensus Conference. t‐tests, Chi‐squared tests, and rank‐sum tests were used to correlate the extent of TB with clinicopathological parameters. Prognostic analysis was performed using Cox regression models and the Kaplan–Meier method.ResultsThe positive detection rate of TB was 45.2% (95/210) in 210 patients with HCC. Patients positive for TB always exhibit lower tumor differentiation, higher hepatitis B virus DNA levels, and more severe liver fibrosis. Multivariate Cox analysis identified TB (hazard ratio [HR]: 2.232, 95% confidence interval [CI]: 1.479–3.368, p < 0.001) as an independent prognostic factor for patients' recurrence‐free survival (RFS), similar to tumor size (HR: 1.070, 95% CI: 1.070–1.142, p = 0.042) and satellite nodule (HR: 2.266, 95% CI: 1.298–3.956, p = 0.004). Kaplan–Meier analysis also demonstrated that TB‐positive patients had a significantly worse RFS. Interestingly, subgroup analysis revealed that among HCC patients with negative microvascular invasion (MVI), TB was also strongly associated with RFS (HR: 3.206, 95% CI: 1.667–6.168, p < 0.001). These findings suggest that TB may serve as a supplemental prognostic biomarker for HCC‐negative MVI.ConclusionsTB is an adverse prognostic biomarker for HCC, particularly in patients negative for MVI. TB evaluation should be considered in the postoperative pathological examination of HCC in clinical practice.
Cardiopulmonary exercise testing and the 2022 definition of pulmonary hypertension
Authors: Habedank Dirk , Ittermann Till , Kaczmarek Sabine , Stubbe Beate , Heine Alexander , Obst Anne , Ewert Ralf 
Published: June 2024

AbstractParameters of cardiopulmonary exercise testing significantly discriminate between healthy subjects and patients with pulmonary hypertension (PH), also according to the new 2022 definition of pulmonary hypertension (mean pulmonary arterial pressure mPAP > 20 mmHg). The cut‐offs indicating on PH were peakVO2 ≤ 16.7 mL/min/kg (Youden‐Index YI = 0.79), petCO2@AT ≤ 34 mmHg (YI = 0.67), and VE/VCO2@AT ≤ 30 (YI = 0.76).
Shallow cumulus cloud fields are optically thicker when they are more clustered
Authors: Alinaghi Pouriya , Janssens Martin , Choudhury Goutam , Goren Tom , Siebesma A. Pier , Glassmeier Franziska 
Published: June 2024

AbstractShallow trade cumuli over subtropical oceans are a persistent source of uncertainty in climate projections. Mesoscale organization of trade cumulus clouds has been shown to influence their cloud radiative effect (CRE) through cloud cover. We investigate whether organization can explain CRE variability independently of cloud‐cover variability. By analyzing satellite observations and high‐resolution simulations, we show that more clustered cloud fields feature geometrically thicker clouds with larger domain‐averaged liquid water paths, smaller cloud droplets, and consequently larger cloud optical depths. The relationships between these variables are shaped by the mixture of deep cloud cores and shallower interstitial clouds or anvils that characterize cloud organization. Eliminating cloud‐cover effects, more clustered clouds reflect up to 20 W/m more instantaneous shortwave radiation back to space.
Rb‐Doped Perovskite Oxides: Surface Enrichment and Structural Reconstruction During the Oxygen Evolution Reaction
Authors: Xie Huachao , Zhang Yuxuan , Liu Panpan , Duo Xuyao , Hu Zhonghui , Yu Jia , Wang Zihan , Yao Guodong , Feng Lingyan , Huang Xing , Ouyang Runhai , Wang Yuanqing 
Published: June 2024

AbstractAlkali‐metal doped perovskite oxides have emerged as promising materials due to their unique properties and broad applications in various fields, including photovoltaics and catalysis. Understanding the complex interplay between alkali metal doping, structural modifications, and their impact on performance remains a crucial challenge. In this study, this challenge is addressed by investigating the synthesis and properties of Rb‐doped perovskite oxides. These results reveal that the doping of Rb into perovskite oxides function as a structural modifier in the as‐synthesized samples and during the oxygen evolution reaction (OER) as well. Electron microscopy and first‐principles calculations confirm the enrichment of Rb on the surface of the as‐synthesized sample. Further investigations into the electrocatalytic reaction revealed that the Rb‐doped perovskite underwent drastic restructuring with Rb leaching and formation of strontium oxide.
Biologically Active Micropatterns of Biomolecules and Living Matter Using Microbubble Lithography
Authors: Ranjan Anand Dev , Bhowmick Sucharita , Gupta Arnab , Mallick Amirul Islam , Banerjee Ayan 
Published: June 2024

AbstractIn situ patterning of biomolecules and living organisms while retaining their biological activity is extremely challenging, primarily because such patterning typically involves thermal stresses that could be substantially higher than the physiological thermal or stress tolerance level. Top‐down patterning approaches are especially prone to these issues, while bottom‐up approaches suffer from a lack of control in developing defined structures and the time required for patterning. A microbubble generated and manipulated by optical tweezers (microbubble lithography) is used to self‐assemble and pattern living organisms in continuous microscopic structures in real‐time, where the material thus patterned remains biologically active due to their ability to withstand elevated temperatures for short exposures. Successful patterns of microorganisms (Escherichia coli, Lactococcus. lactis and the Type A influenza virus) are demonstrated, as well as reporter proteins such as green fluorescent protein (GFP) on functionalized substrates with high signal‐to‐noise ratio and selectivity. Together, the data presented herein may open up fascinating possibilities in rapid in situ parallelized diagnostics of multiple pathogens and bioelectronics.
NaBix/NaVyOz Hybrid Interfacial Layer Enables Stable and Dendrite‐Free Sodium Anodes
Authors: Shi Daowushuang , Lv Xiang , Yang Yang , Zhang Xianghua , Tao Zetian , Xu Chen , Rui Xianhong 
Published: June 2024

AbstractThe challenges of sodium metal anodes, including formation of an unstable solid‐electrolyte interphase (SEI) and uncontrolled growth of sodium dendrites during charge–discharge cycles, impact the stability and safety of sodium metal batteries. Motivated by the promising commercialization potential of sodium metal batteries, it becomes imperative to systematically explore innovative protective interlayers specifically tailored for sodium metal anodes. In this work, a NaBix/NaVyOz hybrid and porous interfacial layer on sodium anode is successfully fabricated via pretreating sodium with bismuth vanadate. The hybrid interlayer effectively combines the advantages of sodium vanadates and alloys, raising a synergistic effect in facilitating sodium deposition kinetics and inhibiting the growth of sodium dendrites. As a result, the modified sodium electrodes (BVO‐Na) can stably cycle for 2000 h at 0.5 mA cm−2 with a fixed capacity of 1 mAh cm−2, and the BVO‐Na||Na3V2(PO4)3 full cell sustains a high capacity of 94 mAh g−1 after 600 cycles at 5 C. This work demonstrates that constructing an artificial hybrid interlayer is a practical solution to obtain high performance anodes in sodium metal batteries.
Tuning Crystal Phase of Palladium–Selenium Nanowires for Enhanced Ethylene Glycol Electrocatalytic Oxidation
Authors: Wang Liping , Yan Wei , Yu Qingping , Liu Liangbin , Kao Cheng‐Wei , Huang Yu‐Cheng , Chan Ting‐Shan , Hu Zhiwei , Lin Haixin , Shen Dazhi , Huang Xiaoqing , Li Yunhua 
Published: June 2024

AbstractAlcohol electrooxidation is pivotal for a sustainable energy economy. However, designing efficient electrocatalysts for this process is still a formidable challenge. Herein, palladium–selenium nanowires featuring distinct crystal phases: monoclinic Pd7Se2 and tetragonal Pd4.5Se for ethylene glycol electrooxidation reaction (EGOR) are synthesized. Notably, the supported monoclinic Pd7Se2 nanowires (m‐Pd7Se2 NWs/C) exhibit superior EGOR activity, achieving a mass activity (MA) and specific activity (SA) of 10.4 A mgPd−1 (18.7 mA cm−2), which are 8.0 (6.7) and 10.4 (8.2) times versus the tetragonal Pd4.5Se and commercial Pd/C and surpass those reported in the literature. Furthermore, m‐Pd7Se2 NWs/C displays robust catalytic activity for other alcohol electrooxidation. Comprehensive characterization and density functional theory (DFT) calculations reveal that the enhanced electrocatalytic performance is attributed to the increased formation of Pd0 on the high‐index facets of the m‐Pd7Se2 NWs, which lowers the energy barriers for the C─C bond dissociation in CHOHCHOH* and the CO* oxidation to CO2*. This study provides palladium‐based alloy electrocatalysts exhibiting the highest mass activity reported to date for the electrooxidation of ethylene glycol, achieved through the crystalline phase engineering strategy.
Montageeinflüsse auf die Langzeittragfähigkeit von Glas/PTFE‐Geweben
Authors: Stranghöner Natalie , Uhlemann Jörg 
Published: June 2024

AbstractMembrantragwerke werden für eine Lebensdauer zwischen 20 und 25 Jahren ausgelegt. Hierzu ist in Deutschland für jedes Tragwerk – ob klein oder groß – bislang eine kombinierte ZiE/vBG erforderlich, die auf Grundlage von Festigkeits‐ und Steifigkeitskennwerten beruht, die am Neumaterial chargenabhängig ermittelt werden. Festigkeitsabmindernde Einflüsse werden über Abminderungsfaktoren durchaus berücksichtigt, allerdings finden Effekte aus der Montage hierbei nur unzureichend Eingang. Gerade Glas/PTFE‐Gewebe sind sensibel gegenüber Montageeinflüssen wie Handling während des Transports, Handling und Temperatur während des Auslegens der Gewebe und Bewitterung, sodass es immer wieder zu Langzeitschäden in Form von Rissen in Glas/PTFE‐Membranüberdachungen kommt, die einen frühzeitigen Austausch der Gesamteindeckung zur Folge haben (können). Untersuchungen zum Einfluss der Bewitterung in Kombination mit handling‐/montagebedingten Knicken in Glas/PTFE‐Geweben haben gezeigt, dass bestimmte Arten von Knicken in Glas/PTFE‐Geweben zwingend zu vermeiden sind, andere sich allerdings nicht nachteilig auf die Langzeittragfähigkeit auswirken (müssen). Der Beitrag gibt sowohl einen Überblick über den aktuellen Kenntnisstand zum Einfluss von Bewitterung und Knicken auf die Langzeittragfähigkeit von Glas/PTFE‐Geweben als auch Empfehlungen zur montagegerechten Ausführung solcher Membrantragwerke, um langfristige Schäden zu vermeiden.