bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blood Glucose Evaluation in the Dental Office
Authors: Mealey Brian L. 
Published: July 2012

Focused Clinical Question: What role does the dental office play in evaluating blood glucose?Summary: Diabetes and prediabetes are highly prevalent conditions. Although a diagnosis of diabetes or prediabetes can only be done with laboratory glucose testing, the use of in‐office glucose testing may be beneficial. Such testing has been recommended as a means of screening patients for undiagnosed diabetes and for evaluating perioperative glucose levels to minimize risk for medical emergencies during dental treatment. This article reviews the issues that dentists should consider in deciding whether to do glucose testing in the dental office. It focuses on the factors that determine glucose dynamics in people with and without diabetes, provides information to enable interpretation of glucose readings, and offers guidelines for action after glucose testing. This article also discusses regulatory issues related to in‐office glucose testing, a discussion commonly absent from articles on this topic.Conclusions: Evaluation of blood glucose in the dental office may be appropriate for assessing perioperative glucose levels to decrease the risk of adverse hypoglycemic events and potentially for screening patients considered to be at risk for diabetes or prediabetes. Clinicians who choose to perform such in‐office testing must be able to correctly interpret the results, know what steps must be taken based on the findings of the test, and understand the governing regulatory guidelines.
A Comparison of Dexmedetomidine Sedation With and Without Midazolam for Dental Implant Surgery
Authors: Wakita Ryo , Kohase Hikaru , Fukayama Haruhisa 
Published: July 2012

Dexmedetomidine (DEX) has a minimal respiratory depressive effect, which is beneficial for dentistry; however, it has the disadvantage of permitting an intraoperative arousal response such that the patient appears to be suddenly no longer sedated, and it has a variable amnestic effect. Since midazolam (MDZ) in an appropriate dose has a profound amnesic effect, we investigated whether additional MDZ compensates for the disadvantage of DEX and enables a better quality of sedation. Forty-three subjects were randomly divided into 4 groups. In group 1, MDZ (0.02 mg/kg) was administered intravenously, followed by a dose of 0.01 mg/kg every 45 minutes. After the first dose of MDZ, preloading with DEX (2 µg/kg/h for 10 minutes) was started and maintained with a dosage of 0.5 µg/kg/h. In group 2, MDZ was infused in the same manner as in group 1, followed by preloading with DEX (1 µg/kg/h for 10 minutes) and maintenance (0.3 µg/kg/h). In group 3, MDZ was infused 0.03 mg/kg, and a dose of 0.01 mg/kg was given every 30 minutes; DEX was administered at the same as in group 2. In group 4, DEX was infused using the same method as in group 1 without MDZ. The sedation levels, amnesia, and patient satisfaction were also investigated. Group 2 had a lower sedation level and a poor evaluation during the first half of the operation. Group 4 did not exhibit an amnesic effect at the beginning of the operation. An evaluation of the degree of patient satisfaction did not reveal any differences among the groups. Optimal sedation was achieved through the combined use of MDZ (0.02 mg/kg with the addition of 0.01 mg/kg every 45 minutes) and DEX (2 µg/kg/h for 10 minutes followed by 0.5 µg/kg/h).
Smooth metric measure spaces, quasi-Einstein metrics, and tractors
Authors: Case Jeffrey 
Published: July 2012

Abstract
We introduce the tractor formalism from conformal geometry to the study of smooth metric measure spaces. In particular, this gives rise to a correspondence between quasi-Einstein metrics and parallel sections of certain tractor bundles. We use this formulation to give a sharp upper bound on the dimension of the vector space of quasi-Einstein metrics, providing a different perspective on some recent results of He, Petersen and Wylie.
Subtleties concerning conformal tractor bundles
Authors: Graham C. , Willse Travis 
Published: July 2012

Abstract
The realization of tractor bundles as associated bundles in conformal geometry is studied. It is shown that different natural choices of principal bundle with normal Cartan connection corresponding to a given conformal manifold can give rise to topologically distinct associated tractor bundles for the same inducing representation. Consequences for homogeneous models and conformal holonomy are described. A careful presentation is made of background material concerning standard tractor bundles and equivalence between parabolic geometries and underlying structures.
Classifying bases for 6D F-theory models
Authors: Morrison David , Taylor Washington 
Published: July 2012

Abstract
We classify six-dimensional F-theory compactifications in terms of simple features of the divisor structure of the base surface of the elliptic fibration. This structure controls the minimal spectrum of the theory. We determine all irreducible configurations of divisors (“clusters”) that are required to carry nonabelian gauge group factors based on the intersections of the divisors with one another and with the canonical class of the base. All 6D F-theory models are built from combinations of these irreducible configurations. Physically, this geometric structure characterizes the gauge algebra and matter that can remain in a 6D theory after maximal Higgsing. These results suggest that all 6D supergravity theories realized in F-theory have a maximally Higgsed phase in which the gauge algebra is built out of summands of the types su(3), so(8), f4, e6, e8, e8, (g2 ⊕ su(2)); and su(2) ⊕ so(7) ⊕ su(2), with minimal matter content charged only under the last three types of summands, corresponding to the non-Higgsable cluster types identified through F-theory geometry. Although we have identified all such geometric clusters, we have not proven that there cannot be an obstruction to Higgsing to the minimal gauge and matter configuration for any possible F-theory model. We also identify bounds on the number of tensor fields allowed in a theory with any fixed gauge algebra; we use this to bound the size of the gauge group (or algebra) in a simple class of F-theory bases.
Left ventricle hydatid cyst mimicking acute coronary syndrome
Authors: Onturk Tekbas Ebru , Tekbas Guven , Ariturk Atilgan Zuhal , Islamoglu Yahya , Cil Habib , Yazici Mehmet 
Published: July 2012

Cardiac echinococcosis rarely mimics acute coronary syndrome. The diagnosis of cardiac hydatid cyst might be difficult on account of varying clinical presentations and nonspesific symptoms. A 75-year-old female was admitted to our hospital with typical chest pain. The patient had no history of previous cardiac symptoms or any illness leading to heart disease. Her ECG revealed ischemic changes. However, her coronary angiography revealed noncritical plaques in the left anterior descending artery. The diagnosis of cardiac echinococcosis was identified using echocardiography, computed tomography and magnetic resonance imaging. The patient was referred to cardiac surgery for resection of the cyst; however, she refused surgery. Albendezol 800 mg/day was prescribed.
The Bone Marrow Functions as the Central Site of Proliferation for Long-Lived NK Cells
Authors: van Helden Mary J. G. , de Graaf Natascha , Boog Claire J. P. , Topham David J. , Zaiss Dietmar M. W. , Sijts Alice J. A. M. 
Published: July 2012

AbstractNK cells play an important role in the early defense against invading pathogens. Although it is well established that infection leads to a substantial, local increase in NK cell numbers, little is known about the mechanisms that trigger their proliferation and migration. In this study, we investigated the dynamics of NK cell responses after intranasal respiratory virus infection. We show that NK cell numbers increased in the airways after influenza virus infection but find no evidence of proliferation either at the site of infection or in the draining lymph nodes. Instead, we find that the bone marrow (BM) is the primary site of proliferation of both immature and mature NK cells during infection. Using an adoptive transfer model, we demonstrate that peripheral, long-lived and phenotypically mature NK cells migrate back to the BM and proliferate there, both homeostatically and in response to infection. Thus, the BM is not only a site of NK cell development but also an important site for proliferation of long-lived mature NK cells.
CD8+CD45RA+CCR7+FOXP3+ T Cells with Immunosuppressive Properties: A Novel Subset of Inducible Human Regulatory T Cells
Authors: Suzuki Masakatsu , Jagger Ann L. , Konya Christine , Shimojima Yasuhiro , Pryshchep Sergey , Goronzy Jörg J. , Weyand Cornelia M. 
Published: July 2012

AbstractCD8 T cells stimulated with a suboptimal dose of anti-CD3 Abs (100 pg/ml) in the presence of IL-15 retain a naive phenotype with expression of CD45RA, CD28, CD27, and CCR7 but acquire new functions and differentiate into immunosuppressive T cells. CD8+CCR7+ regulatory T cells (Tregs) express FOXP3 and prevent CD4 T cells from responding to TCR stimulation and entering the cell cycle. Naive CD4 T cells are more susceptible to inhibition than memory cells. The suppressive activity of CD8+CCR7+ Tregs is not mediated by IL-10, TGF-β, CTLA-4, CCL4, or adenosine and relies on interference with very early steps of the TCR signaling cascade. Specifically, CD8+CCR7+ Tregs prevent TCR-induced phosphorylation of ZAP70 and dampen the rise of intracellular calcium in CD4 T cells. The inducibility of CD8+CCR7+ Tregs is correlated with the age of the individual with PBLs of donors older than 60 y yielding low numbers of FOXP3low CD8 Tregs. Loss of CD8+CCR7+ Tregs in the elderly host may be of relevance in the aging immune system as immunosenescence is associated with a state of chronic smoldering inflammation.
Cytokine Secretion by CD4+ T Cells at the Immunological Synapse Requires Cdc42-Dependent Local Actin Remodeling but Not Microtubule Organizing Center Polarity
Authors: Chemin Karine , Bohineust Armelle , Dogniaux Stéphanie , Tourret Marie , Guégan Sarah , Miro Francesc , Hivroz Claire 
Published: July 2012

Abstract
Cytokine secretion by T lymphocytes plays a central role in mounting adaptive immune responses. However, little is known about how newly synthesized cytokines, once produced, are routed within T cells and about the mechanisms involved in regulating their secretions. In this study, we investigated the role of cytoskeleton remodeling at the immunological synapse (IS) in cytokine secretion. We show that a key regulator of cytoskeleton remodeling, the Rho GTPase Cdc42, controls IFN-γ secretion by primary human CD4+ T lymphocytes. Surprisingly, microtubule organizing center polarity at the IS, which does not depend on Cdc42, is not required for cytokine secretion by T lymphocytes, whereas microtubule polymerization is required. In contrast, actin remodeling at the IS, which depends on Cdc42, controls the formation of the polymerized actin ring at the IS, the dynamic concentration of IFN-γ–containing vesicles inside this ring, and the secretion of these vesicles. These results reveal a previously unidentified role of Cdc42-dependent actin remodeling in cytokine exocytosis at the IS.
Acquisition of MHC:Peptide Complexes by Dendritic Cells Contributes to the Generation of Antiviral CD8+ T Cell Immunity In Vivo
Authors: Smyth Lesley A. , Hervouet Catherine , Hayday Thomas , Becker Pablo D. , Ellis Richard , Lechler Robert I. , Lombardi Giovanna , Klavinskis Linda S. 
Published: July 2012

Abstract
There is an increasing body of evidence suggesting that the transfer of preformed MHC class I:peptide complexes between a virus-infected cell and an uninfected APC, termed cross-dressing, represents an important mechanism of Ag presentation to CD8+ T cells in host defense. However, although it has been shown that memory CD8+ T cells can be activated by uninfected dendritic cells (DCs) cross-dressed by Ag from virus-infected parenchymal cells, it is unknown whether conditions exist during virus infection in which naive CD8+ T cells are primed and differentiate to cytolytic effectors through cross-dressing, and indeed which DC subset would be responsible. In this study, we determine whether the transfer of MHC class I:peptide complexes between infected and uninfected murine DC plays a role in CD8+ T cell priming to viral Ags in vivo. We show that MHC class I:peptide complexes from peptide-pulsed or virus-infected DCs are indeed acquired by splenic CD8α− DCs in vivo. Furthermore, the acquired MHC class I:peptide complexes are functional in that they induced Ag-specific CD8+ T cell effectors with cytolytic function. As CD8α− DCs are poor cross-presenters, this may represent the main mechanism by which CD8α− DCs present exogenously encountered Ag to CD8+ T cells. The sharing of Ag as preformed MHC class I:peptide complexes between infected and uninfected DCs without the restraints of Ag processing may have evolved to accurately amplify the response and also engage multiple DC subsets critical in the generation of strong antiviral immunity.
Negative Impact of IFN-γ on Early Host Immune Responses to Retroviral Infection
Authors: Duley Amanda K. , Ploquin Mickaël J.-Y. , Eksmond Urszula , Ammann Christoph G. , Messer Ronald J. , Myers Lara , Hasenkrug Kim J. , Kassiotis George 
Published: July 2012

Abstract
The immune system is tasked with defending against a myriad of microbial infections, and its response to a given infectious microbe may be strongly influenced by coinfection with another microbe. It was shown that infection of mice with lactate dehydrogenase-elevating virus (LDV) impairs early adaptive immune responses to Friend virus (FV) coinfection. To investigate the mechanism of this impairment, we examined LDV-induced innate immune responses and found LDV-specific induction of IFN-α and IFN-γ. LDV-induced IFN-α had little effect on FV infection or immune responses, but unexpectedly, LDV-induced IFN-γ production dampened Th1 adaptive immune responses and enhanced FV infection. Two distinct effects were identified. First, LDV-induced IFN-γ signaling indirectly modulated FV-specific CD8+ T cell responses. Second, intrinsic IFN-γ signaling in B cells promoted polyclonal B cell activation and enhanced early FV infection, despite promotion of germinal center formation and neutralizing Ab production. Results from this model reveal that IFN-γ production can have detrimental effects on early adaptive immune responses and virus control.
Validating the Adolescent/Adult Sensory Profile and Examining its Ability to Screen Sensory Processing Difficulties among Israeli People
Authors: Engel-Yeger Batya 
Published: July 2012

Purpose: The purpose of this study was to (1) validate the Hebrew version of the Adolescent/Adult Sensory Profile (AASP); (2) screen sensory processing difficulties, as expressed in daily living in a vast range of ages of healthy Israeli adolescents, adults and older people; and (3) examine gender effect on sensory processing in the different age groups. Findings: Good internal consistency was found for each of the AASP quadrants, although factor analysis did not find total similarity between the Hebrew version of the AASP and the original AASP. Sensory processing difficulties were shown by 22–42% of the participants in the different age groups. Older participants had lower tendency for Sensation Seeking. Females were more sensitive than males in the age groups of 11–17 years and 18–64 years. Conclusion: In general, the Hebrew version of the AASP was found to be valid and succeeded in profiling sensory processing difficulties along the life span of typical Israeli adolescents and adults. Further studies should apply the Hebrew version of the AASP to screen sensory processing difficulties among individuals with disabilities and elaborate their impact on people's performance/participation in daily activities.
Ultrasound Guided Supraclavicular Central vein Cannulation in Adults: A Technical Report
Authors: Bertini Pietro , Frediani Massimo 
Published: July 2012

Purpose Ultrasound-guided (USG) central vein cannulation has become very popular among anesthesiologists and critical care physicians in the last decade and it has been advocated as the gold standard practice for internal jugular vein (IJV) catheterization. Methods We report a technique used at our second level hospital for cannulating either subclavian vein or innominate vein using a supraclavicular (SCV) approach under real time ultrasound guidance for elective positioning of long, medium or short-term central venous catheters (CVC). We report one year of practice. Results A total of 347 intravascular devices were positioned; successful USG SCV cannulation with no complication, failure or malposition was reported in 119 cases. Conclusions The SCV approach under ultrasound guidance is feasible and safe.
LaPO4 Mineral Liquid Crystalline Suspensions with Outstanding Colloidal Stability for Electro‐Optical Applications
Authors: Kim Jongwook , de la Cotte Alexis , Deloncle Rodolphe , Archambeau Samuel , Biver Claudine , Cano Jean‐Paul , Lahlil Khalid , Boilot Jean‐Pierre , Grelet Eric , Gacoin Thierry 
Published: July 2012

AbstractMineral liquid crystals are materials in which mineral's intrinsic properties are combined with the self‐organization behavior of colloids. However, the use of such a system for practical application, such as optical switching, has rarely been demonstrated due to the fundamental drawbacks of colloidal systems such as limited dispersion stability. Studying colloidal suspensions of LaPO4 nanorods, it is found that drastic improvement of colloidal stability can be obtained through a transfer of particles from water towards ethylene glycol, thus enabling the investigation of liquid crystalline properties of these concentrated suspensions. Using polarization microscopy and small‐angle x‐ray scattering (SAXS), self‐organization into nematic and columnar mesophases is observed enabling the determination of the whole phase diagram as a function of ionic strength and rod volume fraction. When an external alternative electric field is applied, a very efficient orientation of the nanorods in the liquid‐crystalline suspension is obtained, which is associated with a significant optical birefringence. These properties, combined with the high colloidal stability, are promising for the use of such high transparent and athermal material in electro‐optical devices.
Electrically Induced Disassembly of Electroactive Multilayer Films Fabricated from Water Soluble Polythiophenes
Authors: Mawad Damia , Molino Paul J. , Gambhir Sanjeev , Locke Julie M. , Officer David L. , Wallace Gordon G. 
Published: July 2012

AbstractA novel approach to induce disassembly of electroactive multilayer films fabricated by the layer by layer assembly technique is reported. Electroactive multilayer films are constructed using water soluble polythiophenes, i.e., negatively charged poly[ammonium (3‐thienyl)ethoxypropanesulfonate] (SPT) and positively charged poly[3‐(3′‐thienyloxy)ethyltriethylammonium] (APT). “Induced” dissolution of the films in response to applied potential is investigated using a quartz crystal microbalance equipped with an electrochemical cell module (EC‐QCM‐D). Disassembly of the films is observed in response to three different potentials: +650, –650, and ±650 mV; however the time for dissolution varies as a function of the potential with films subject to +650 mV dissolving fully in 19 h compared to 42 h for films subject to –650 mV. These electroactive films and their controlled dissolution under applied potential represent an attractive architectural feature for bionic devices that could benefit from their conductivity and dissolution over time.
Biochemical and genetic analyses of childhood attention deficit/hyperactivity disorder
Authors: Caylak Emrah 
Published: July 2012

AbstractAttention deficit/hyperactivity disorder (ADHD) in children is a neurobehavioral disorder characterized by inattention, hyperactivity, and/or impulsivity. The biochemical abnormalities and genetic factors play significant roles in the etiology of ADHD. These symptoms affect the behavior performance and social relationships of children in school and at home. Recently, many studies about biochemical abnormalities in ADHD have been published. Several research groups have also suggested the genetic contribution to ADHD, and attempted to identify susceptibility and candidate genes for this disorder through the genetic linkage and association studies. To date, these studies have reported substantial evidence implicating several genes (dopaminergic: DRD4, DAT1, DRD5, COMT; noradrenergic: DBH, ADRA2A; serotonergic: 5‐HTT, HTR1B, HTR2A; cholinergic: CHRNA4, and central nervous system development pathway: SNAP25, BDNF) in the etiology of ADHD. Understanding the biochemistry and genetics of ADHD will allow us to provide a useful addition with other treatment procedures for ADHD. © 2012 Wiley Periodicals, Inc.
Event‐by‐event simulation of quantum phenomena
Authors: De Raedt H. , Michielsen K. 
Published: July 2012

AbstractA discrete‐event simulation approach is reviewed that does not require the knowledge of the solution of the wave equation of the whole system, yet reproduces the statistical distributions of wave theory by generating detection events one‐by‐one. The simulation approach is illustrated by applications to a two‐beam interference experiment and two Bell test experiments, an Einstein‐Podolsky‐Rosen‐Bohm experiment with single photons employing post‐selection for pair identification and a single‐neutron Bell test interferometry experiment with nearly 100 % detection efficiency.
Role of 208Pb daughter nucleus and nuclear shell effects in trans‐lead cluster radioactivity by emission of neon clusters from 218–236U isotopes
Authors: Swamy G.S. , Umesh T.K. 
Published: July 2012

AbstractIn the present work, the cluster radioactivity of even A uranium isotopes (218–236U) with the emission of both alpha‐like and non‐alpha‐like neon clusters (20,22,24,26,28Ne) was studied. The decimal logarithm of half‐lives (expressed in seconds) were calculated by three different approaches based on (i) the single line of Universal curve (UNIV) for alpha and cluster radioactive decay, (ii) the Universal Decay law (UDL) and (iii) by considering a fission‐like model in which the interacting nuclear potential barrier was taken to be the sum of Coulomb and proximity potentials (CPPM) respectively. Based on the half‐lives calculated by using the three different approaches mentioned above, significance of the role of 208Pb nucleus (doubly magic nucleus) and nuclear shell effects in trans‐lead cluster radioactivity were investigated. The calculated half‐lives have also been compared with available experimental results. It was observed that cluster decay modes leading to the formation of 208Pb daughter nucleus have the lowest half‐lives. This implies that there is a shell closure at proton number (Z) = 82 and neutron number (N) = 126. Hence, it confirms the existence of nuclear shell effect and stresses the significance of role of 208Pb daughter nucleus in the trans‐lead cluster radioactivity. It can be noticed that the calculated half‐lives for several cluster decay modes are well within the present experimental upper limit for measurements (T1/2 < 1030S). These results may be useful for future experiments.