bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utilization of clinical practice guidelines for cancer care in routine practice and during the coronavirus disease 2019 pandemic in India
Authors: Mathur Prashant , Ramamoorthy Thilagavathi , Lakshminarayana Sudarshan Kondalli , Nath Anita , Mathew Stany , Rajput Gurpreet Kaur 
Published: April 2024

AbstractAimThe coronavirus disease 2019 (COVID‐19) pandemic affected cancer service delivery and the feasibility of following the standard treatment guidelines. The present paper describes the use of clinical care guidelines for cancer management in routine practice and the approach adopted towards cancer care during the COVID‐19 pandemic in India.MethodsA web‐based survey was done in 107 hospitals (including public and private health facilities) that hosted Hospital‐Based Cancer Registries under the National Cancer Registry Programme. The participants comprised Principal Investigators of these registries, who were also medical, surgical, and radiation oncology clinicians. The survey was done between May 1, 2021, and July 31, 2021. Participants were provided with a web link for the survey questionnaire, confidential login, and password.ResultsThe study found high utilization of Clinical Practice Guidelines (CPGs) during practice, with eight out of ten physicians constantly to referring them. The study reported lack of knowledge, skills, and training to administer the treatment based on the guidelines followed by organizational infrastructure and affordability of treatment by the patients as the factors hampering utilization. International clinical guidelines were preferred when compared to national guidelines. The COVID‐19 pandemic decreased the use of CPGs, wherein six out of ten clinicians reported their use.ConclusionStakeholders who formulate clinical guidelines must consider the practical aspects and feasibility of implementing such guidelines during a pandemic and similar situations. This should be coupled with adequate changes in care practice to ensure optimal care delivery and a continuum of cancer care in routine and pandemic‐imposed situations.
Introduction ‐ Anthropology and the security encounter: Toward an abolitionist anthropology in the age of permanent war
Authors: Glück Zoltán 
Published: April 2024

AbstractAnthropologists need to grapple politically with the ways in which security, war and militarization shape our fields of study. This special section of American Anthropologist, “Forever War: Anthropology and the Global War on Terror,” brings together scholars studying, writing and enacting their politics amidst the immense socio‐political impacts of the Global War on Terror. In this introductory article, I offer the concept of “the security encounter” to describe the complex and inherently political conditions of doing anthropology within the current conjuncture, as well as a provocation for anthropologists to adopt an abolitionist approach to security, militarization, and permanent war which increasingly structure our lives and work.
Deep Learning for prediction of late recurrence of retinal detachment using preoperative and postoperative ultra‐wide field imaging
Authors: Catania Fiammetta , Chapron Thibaut , Crincoli Emanuele , Miere Alexandra , Abdelmassih Youssef , Beaumont William , Chehaibou Ismael , Metge Florence , Bruneau Sebastien , Bonnin Sophie , Souied Eric H. , Caputo Georges 
Published: April 2024

AbstractPurposeTo elaborate a deep learning (DL) model for automatic prediction of late recurrence (LR) of rhegmatogenous retinal detachment (RRD) using pseudocolor and fundus autofluorescence (AF) ultra‐wide field (UWF) images obtained preoperatively and postoperatively.Materials and MethodsWe retrospectively included patients >18 years who underwent either scleral buckling (SB) or pars plana vitrectomy (PPV) for primary or recurrent RRD with a post‐operative follow‐up >2 years. Records of RRD recurrence between 6 weeks and 2 years after surgery served as a ground truth for the training of the deep learning (DL) models. Four separate DL models were trained to predict LR within the 2 postoperative years (binary outputs) using, respectively, UWF preoperative and postoperative pseudocolor images and UWF preoperative and postoperative AF images.ResultsA total of 412 eyes were included in the study (332 eyes treated with PPV and 80 eyes with SB). The mean follow‐up was 4.0 ± 2.1 years. The DL models based on preoperative and postoperative pseudocolor UWF imaging predicted recurrence with 85.6% (sensitivity 86.7%, specificity 85.4%) and 90.2% accuracy (sensitivity 87.0%, specificity 90.8%) in PPV‐treated eyes, and 87.0% (sensitivity 86.7%, specificity 87.0%) and 91.1% (sensitivity 88.2%, specificity 91.9%) in SB‐treated eyes, respectively. The DL models using preoperative and postoperative AF‐UWF imaging predicted recurrence with 87.6% (sensitivity 84.0% and specificity 88.3%) and 91.0% (sensitivity 88.9%, specificity 91.5%) accuracy in PPV eyes, and 86.5% (sensitivity 87.5%; specificity 86.2%) and 90.6% (sensitivity 90.0%, specificity 90.7%) in SB eyes, respectively. Among the risk factors detected with visualisation methods, potential novel ones were extensive laser retinopexy and asymmetric staphyloma.ConclusionsDL can accurately predict the LR of RRD based on UWF images (especially postoperative ones), which can help refine follow‐up strategies. Saliency maps might provide further insight into the dynamics of RRD recurrence.
Unlocking mitochondrial drug targets: The importance of mitochondrial transport proteins
Authors: Hoogstraten Charlotte A. , Schirris Tom J. J. , Russel Frans G. M. 
Published: April 2024

AbstractA disturbed mitochondrial function contributes to the pathology of many common diseases. These organelles are therefore important therapeutic targets. On the contrary, many adverse effects of drugs can be explained by a mitochondrial off‐target effect, in particular, due to an interaction with carrier proteins in the inner membrane. Yet this class of transport proteins remains underappreciated and understudied. The aim of this review is to provide a deeper understanding of the role of mitochondrial carriers in health and disease and their significance as drug targets. We present literature‐based evidence that mitochondrial carrier proteins are associated with prevalent diseases and emphasize their potential as drug (off‐)target sites by summarizing known mitochondrial drug–transporter interactions. Studying these carriers will enhance our knowledge of mitochondrial drug on‐ and off‐targets and provide opportunities to further improve the efficacy and safety of drugs.
Letter: Association of persistently high HBsAg levels during HBeAg‐seropositive stage and hepatocellular carcinoma risk in chronic hepatitis B patients—Authors' reply
Authors: Lin Hsin‐Che , Jeng Wen‐Juei , Yang Hwai‐I 
Published: April 2024

LINKED CONTENTThis article is linked to Lin et al papers. To view these articles, visit https://doi.org/10.1111/apt.17915 and https://doi.org/10.1111/apt.17971
The forgotten adaptive social benefits of social learning in animals
Authors: Harrison Rachel A. , Dongre Pooja , van Schaik Carel P. , van de Waal Erica 
Published: April 2024

ABSTRACTTheoretical and empirical scholars of cultural evolution have traditionally studied social learning strategies, such as conformity, as adaptive strategies to obtain accurate information about the environment, whereas within social psychology there has been a greater focus upon the social consequences of such strategies. Although these two approaches are often used in concert when studying human social learning, we believe the potential social benefits of conformity, and of social learning more broadly, have been overlooked in studies of non‐humans. We review evidence from studies of homophily, imitation, and rapid facial mimicry that suggests that behaving like others affords social benefits to non‐human animals and that behaviour matching may be deployed strategically to increase affiliation. Furthermore, we review studies of conformity in dispersers, and suggest that forgoing personal information or preferences in favour of those of the new group during immigration may be a strategy to facilitate social integration. We therefore propose that the informational and social functions of conformity apply to humans and animals alike. We use this perspective to generate several interesting research questions to inspire work in this field. For example, under what conditions do animals use informational or social conformity and what role does uncertainty play in social learning in immigrant individuals?
Optimisation of cationic dye dyeing process of Porel fabrics using response surface methodology
Authors: Chang Yuan , Hou Keru , Ji Yating , Yun Zhongfang , Cheng Guolei , Cai Zaisheng 
Published: April 2024

AbstractPolyethylene terephthalate (PET) fibre, widely utilised across diverse industries, suffers from inherent drawbacks such as inadequate moisture absorption, limited hydrophilicity, and susceptibility to static electricity. To address these limitations, Porel fibre has emerged as a novel modified polyester fibre that incorporates flexible aliphatic polyester into its macromolecular chain. This innovative design not only overcomes the deficiencies of PET fibre but also enables it to be dyed using cationic dyes or disperse dyes under atmospheric pressure conditions. However, the investigation of the dyeing process of cationic dyes on Porel textiles remains relatively scarce. In this work, response surface methodology (RSM) was used to optimise the dyeing process of Porel fabrics with C.I. Basic Blue 162. The effects of dyeing temperature, dyeing time, and dye concentration on exhaustion percentage and colour strength (K/S value) were investigated using the Central Composite Design (CCD) method. The optimal dyeing process condition was as follows: a dyeing temperature of 96°C, a dyeing time of 51 min, a dye concentration of 3.6% owf, a dye solution pH value of 4–5, and a liquor ratio of 1:20. Under the optimal dyeing process conditions, the Porel fabrics achieved an exhaustion percentage of 96.2% and a K/S value of 36.0. The aforementioned efforts endow Porel fibre with high‐quality dyeing capabilities and broaden the application prospects of polyester textiles.
Flexible migration and habitat use strategies of an endangered waterbird during hydrological drought
Authors: Pearse Aaron T. , Caven Andrew J. , Baasch David M. , Bidwell Mark T. , Conkin John A. , Brandt David A. 
Published: April 2024

AbstractWildlife species confront threats from climate and land use change, exacerbating the influence of extreme climatic events on populations and biodiversity. Migratory waterbirds are especially vulnerable to hydrological drought via reduced availability of surface water habitats. We assessed how whooping cranes (Grus americana) modified habitat use and migration strategies during drought to evaluate their resilience to changing conditions and adaptive capacity. We categorized >8000 night‐roost sites used by 146 cranes from 2010 to 2022 and examined relative use during non‐drought, moderate drought, and extreme drought conditions. We found cultivated and uncultivated palustrine and lacustrine wetlands were generally used less during droughts than non‐drought conditions. Conversely, impounded palustrine and lacustrine systems and rivers served more frequently as drought refugia (i.e., used more during drought than non‐drought conditions). Night roosts occurred primarily on private lands (86% overall); public land use decreased with latitude and increased with drought severity, with greatest use (56%) occurring during severe autumn drought in the southern Great Plains. Quantifying use of identified critical habitats in the United States indicated that Cheyenne Bottoms State Waterfowl Management Area and Quivira National Wildlife Refuge were used less during drought, and the Central Platte River and Salt Plains National Wildlife Refuge received similar use during drought compared to non‐drought conditions. Our findings provide insights into compensatory use of habitats, where impounded surface water may function in a complementary fashion with natural wetlands. Collectively, these and other types of wetlands distributed across the migration corridor provided a reliable network of habitat available across the Great Plains. A diversity of wetlands available during variable environmental conditions would be useful in supporting continued recovery of whooping cranes and likely have benefits for a wide array of migratory birds.
Underprediction of extirpation and colonisation following climate and land‐use change using species distribution models
Authors: Auffret Alistair G. , Nenzén Hedvig , Polaina Ester 
Published: April 2024

AbstractAimTo evaluate the performance of species distribution models in predicting observed colonisations, persistences and extirpations in response to changes in climate and land use over a multi‐decadal period.LocationSweden.MethodsWe use historical (early 20th century) land use and climate data to build species distribution models for 84 plant species across three provinces of Sweden. Model performance was then evaluated internally using a subset of the historical data for cross‐validation, as well as by using the models to project occurrences to the modern day and validating them with observed occurrences from 1990 to 2020. We then analysed predicted and observed occurrences in the modern period in terms of persistence, extirpation (local extinction) and colonisation in relation to species' habitat and climate associations.ResultsWe found overall high agreement between evaluation methods, although internal evaluation gave consistently higher values for model performance (using true skill statistic, TSS). Overall, extirpations were worst predicted, with on average fewer than one‐third of each species' extirpations being foreseen by the models. Colonisations were better predicted, while persistences were relatively well‐predicted. Predictive accuracy of colonisations was higher for species with relatively warmer temperature associations (climate‐driven expansion), while extirpations were better predicted in cool‐related species (retractions at cool edges). Colonisations of forest‐associated species were more common than predicted (underpredicted), despite widespread patterns of afforestation. Assessing grid‐cell level turnover, we found that in grid cells that experienced the largest changes in terms of climate and land use, predicted extirpations were less likely to have happened.Main ConclusionsWe found that commonly applied modelling approaches have limited ability to predict observed changes in species occurrences, especially extirpations. This suggests that we should take predictions of future biodiversity loss very seriously. However, the ability for species to (at least temporarily) persist in unsuitable conditions could be an opportunity for biodiversity conservation.
Breaking free? The evolution of intra‐Asian trade at the dawn of globalization (1795–1839)
Authors: Ayuso‐Diaz Alejandro 
Published: April 2024

AbstractThis article contributes to the scholarly discourse on the repercussions of trade liberalization in the late eighteenth and early nineteenth centuries that contributed to early globalization, offering a perspective that extends beyond the traditional focus on Atlantic economies. Our study centres on East and Southeast Asia, pivotal in Pacific and Indian Ocean trade. We overcome data scarcity by presenting a new, partner‐disaggregated imports dataset spanning 10 ports across the region from 1795 to 1839. Employing a gravity model and incorporating interactions, we assess the degree of intra‐Asian trade and its evolution following key events that liberalized East and Southeast Asian commerce in a period when measurable global integration started to become apparent. Supporting new Asian scholarship, our results highlight the remarkable intra‐Asian trade before the high colonial era. We also show that, in general, colonial trade policies fostering inter‐continental trade disproportionately augmented colonial imports in East and Southeast Asia, eclipsing gains in intra‐Asian or Pacific trade, especially before 1830. We explore the impact of the influx of British textiles in the region as a mechanism to explain these trends. Our study illuminates complex trade dynamics in East and Southeast Asia during a transformative period of measurable global integration.
The US–China trade war and corporate innovation: Evidence from China
Authors: Kong Dongmin , Liu Chen , Narayan Paresh Kumar , Sharma Susan Sunila 
Published: April 2024

AbstractThis study investigates the effect of the US–China trade war on corporate innovation in the context of China. We find that the first‐order effect of the trade war on corporate innovation is significantly negative. That is, Chinese firms exposed to the US–China trade war have lower numbers of patent applications and invention patent applications. Underlying mechanisms include reductions in market expansion and innovation input. Our findings are more pronounced for firms connected to the United States and those suffering financial distress and for non‐state‐owned enterprises. We further contribute to the literature by showing that firms with developed managerial ability, more confident managers, and better corporate social responsibility performance tend to increase innovation for competitiveness in response to the trade war. Finally, we explore the effect of Chinese retaliatory tariff shocks on corporate innovation and find that US tariffs and Chinese retaliatory tariffs hinder corporate innovation in China.
Turnover of EDEM1, an ERAD‐enhancing factor, is mediated by multiple degradation routes
Authors: Katsuki Riko , Kanuka Mai , Ohta Ren , Yoshida Shusei , Tamura Taku 
Published: April 2024

AbstractQuality‐based protein production and degradation in the endoplasmic reticulum (ER) are essential for eukaryotic cell survival. During protein maturation in the ER, misfolded or unassembled proteins are destined for disposal through a process known as ER‐associated degradation (ERAD). EDEM1 is an ERAD‐accelerating factor whose gene expression is upregulated by the accumulation of aberrant proteins in the ER, known as ER stress. Although the role of EDEM1 in ERAD has been studied in detail, the turnover of EDEM1 by intracellular degradation machinery, including the proteasome and autophagy, is not well understood. To clarify EDEM1 regulation in the protein level, degradation mechanism of EDEM1 was examined. Our results indicate that both ERAD and autophagy degrade EDEM1 alike misfolded degradation substrates, although each degradation machinery targets EDEM1 in different folded states of proteins. We also found that ERAD factors, including the SEL1L/Hrd1 complex, YOD1, XTP3B, ERdj3, VIMP, BAG6, and JB12, but not OS9, are involved in EDEM1 degradation in a mannose‐trimming‐dependent and ‐independent manner. Our results suggest that the ERAD accelerating factor, EDEM1, is turned over by the ERAD itself, similar to ERAD clients.
Vitamin D receptor gene polymorphisms role in COVID‐19 severity: Results of a Mexican patients’ cohort
Authors: Ochoa‐Ramírez Luis Antonio , Corona‐Angulo Alba Lissy , Ríos‐Burgueño Efrén Rafael , Sánchez‐Zazueta Jorge Guillermo , Becerra‐Loaiza Denisse Stephania , Velarde‐Félix Jesús Salvador 
Published: April 2024

AbstractVitamin D status has been involved with coronavirus disease 19 (COVID‐19) severity. This may be mediated by vitamin D metabolism regulatory genes. Of interest is the vitamin D receptor (VDR) gene, which has been previously associated with other inflammatory and respiratory diseases. In order to investigate the role of VDR gene polymorphisms in COVID‐19 severity and outcome, a total of 292 COVID‐19 patients were classified according to severity in moderate (n = 56), severe (n = 89) and critical (n = 147) and, according to outcome in survivor (n = 163) and deceased (n = 129), and analysed for FokI and TaqI VDR gene polymorphisms by polymerase chain reaction‐based restriction enzyme digestion. The FokI and TaqI single nucleotide polymorphisms (SNPs) were not associated with COVID‐19 severity or mortality individually but when analysed by haplotype, TC was associated with an increased risk of presenting critical COVID‐19. Additionally, FokI CT genotype was more frequent in COVID‐19 patients with hypertension, and T allele carriers presented higher aspartate aminotransferase levels. Our results suggest a relationship between VDR FokI and TaqI SNPs and COVID‐19 severity in Mexican population. Although there are some previous reports of VDR polymorphisms in COVID‐19, this represents the first report in Latin American population. Further studies on other populations are encouraged.
Tumour‐derived exosome SNHG17 induced by oestrogen contributes to ovarian cancer progression via the CCL13–CCR2–M2 macrophage axis
Authors: Liang Haiyan , Geng Shuo , Wang Yadong , Fang Qing , Xin Yongfeng , Li Yanqing 
Published: April 2024

AbstractOestrogen is known to be strongly associated with ovarian cancer. There was much work to show the importance of lncRNA SNHG17 in ovarian cancer. However, no study has revealed the molecular regulatory mechanism and functional effects between oestrogen and SNHG17 in the development and metastasis of ovarian cancer. In this study, we found that SNHG17 expression was significantly increased in ovarian cancer and positively correlated with oestrogen treatment. Oestrogen could promote M2 macrophage polarization as well as ovarian cancer cells SKOV3 and ES2 cell exosomal SNHG17 expression. When exposure to oestrogen, exosomal SNHG17 promoted ovarian cancer cell proliferation, migration, invasion and epithelial‐mesenchymal transition (EMT) in vitro, and tumour growth and lung metastasis in vivo by accelerating M2‐like phenotype of macrophages. Mechanically, exosomal SNHG17 could facilitate the release of CCL13 from M2 macrophage via the PI3K‐Akt signalling pathway. Moreover, CCL13‐CCR2 axis was identified to be involved in ovarian cancer tumour behaviours driven by oestrogen. There results demonstrate a novel mechanism that exosomal SNHG17 exerts an oncogenic effect on ovarian cancer via the CCL13–CCR2–M2 macrophage axis upon oestrogen treatment, of which SNHG17 may be a potential biomarker and therapeutic target for ovarian cancer responded to oestrogen.
A simple method to identify sex at pre‐pupal stages of Spodoptera frugiperda (Lepidoptera: Noctuidae)
Authors: Liu Zhuangzhuang , Wang Peng , He Yanjin , Zou Luming , Gao Qionghua , Xiao Yutao 
Published: April 2024

AbstractThe sex of Lepidoptera species can typically be identified at the pupal or adult stage by their morphological characteristics. However, for most species, no obvious sex‐specific traits can be used at the larval or embryonic stage. The growing interest in studying sex determination and differentiation, along with the potential application of research findings in genetic regulation techniques, is promoting the advancement of new sexing methods at early developmental stages. In this study, the sex of individual eggs and larvae was successfully identified by means of W chromosome molecular markers, which were identified through analysing the previously published W chromosome sequence data of Spodoptera frugiperda (Lepidoptera: Noctuidae). Additionally, we present methods to extract DNA and RNA from individual eggs and larval hemolymph. These techniques provide a simple and dependable method to identify sex at pre‐pupal stages. This approach could potentially be extended to other Lepidoptera species of which the W chromosome information is available.