bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sodium arsenite impairs sperm quality via downregulating the ZMYND15 and ZMYND10
Authors: Li Xiangli , Shen Kaina , Yuan Dunxuan , Li Xi , Quan Jinrou , Tian Fangzhou , Yang Yan , Zhang Li , Wang Junling 
Published: May 2024

AbstractZinc finger MYND‐type containing 15 (ZMYND15) has been documented to play important roles in spermatogenesis, and mutants contribute to recessive azoospermia, severe oligozoospermia, non‐obstructive azoospermia, teratozoospermia, even male infertility. ZMYND10 is involved in sperm motility. Whether environmental pollutants impair male fertility via regulating the expression of ZMYND15 and ZMYND10 has not been studied. Arsenic exposure results in poor sperm quality and male infertility. In order to investigate whether arsenic‐induced male reproductive toxicity is related to the expression of ZMYND15, ZMYND10 and their target genes, we established a male rat model of sodium arsenite exposure‐induced reproductive injury, measured sperm quality, serum hormone levels, mRNA and protein expressions of intratesticular ZMYND15 and ZMYND10 as well as their target genes. The results showed that, in addition to the increased mRNA expression of Tnp1, sodium arsenite exposure reduced sperm quality, serum hormone levels, and mRNA and protein expression of intratesticular ZMYND15 and ZMYND10 and their target genes in male rats compared with the control group (p < .05). Therefore, our study first showed that the environmental pollutant arsenic impairs sperm quality in male rats by reducing the expression of ZMYND10 and ZMYND15 and their regulatory genes, which provides a possible diagnostic marker for environmental pollutants‐induced male infertility.
Personalized medicine in China: An overview of policies, programs, and actions in China
Authors: Di Marcantonio Marzia , Beccia Flavia , Maio Alessandra , Wang Lili , Wang Wenya , Ricciardi Walter , Boccia Stefania 
Published: May 2024

AbstractBackgroundOver the past decade, the ascent of personalized medicine (PM) has catalyzed pivotal transformations in healthcare systems on a global scale. Recognizing its crucial importance, the European Commission has prioritized PM within its research directives, allocating funding for international collaborative projects, such as the “Integrating China in the International Consortium for Personalized Medicine” (IC2PerMed) project, which aims to facilitate China's integration into the International Consortium for Personalized Medicine (ICPerMed). This research presents the delineation and examination of existing policies governing PM in China, describing the regulatory framework that encompasses PM within the country.MethodsPubMed, Baidu.com, Google Scholar, Google, and Microsoft Academic as well as official repositories of national and international institutions, were searched to find publications and information pertaining to policies, programs, and action plans concerning PM in China in English and Chinese language. This search encompassed both national and local perspectives and covered documents published until December 2023.ResultsSixteen policies, 18 programs, and 11 actions in China on both national and local base addressing PM approaches and themes were identified. The policies mainly focused on genetics and human genetic resources management, and big data and data security requirements. China's strategic plans and programs emphasized PM's integration into national health strategies, mostly through 13th 5‐year plans and special plans. Finally, the action plans focused on specific applications of PM. The Health and Family Planning Commission and National Health Commission standardized molecular testing, physician approval, and clinical use of antitumor drugs.DiscussionIn recent years, China has implemented a variety of policy measures to address healthcare challenges, focusing on personalized treatment for an aging population. Despite increased government spending, challenges persist, including rising out‐of‐pocket payments and regional disparities. China is heavily investing in PM, utilizing extensive health datasets and diagnostic technologies. China has prioritized technological innovation and large‐scale data collection. While disparities exist between China and Europe, both aim to integrate PM insights into clinical practice for better healthcare outcomes.
Privacy Considerations in Archival Practice and Research
Authors: Windon Katrina , Youngblood Joshua 
Published: May 2024

AbstractPrivacy considerations are woven throughout archival practice, from the acquisition and stewardship of archival collections to the generation and retention of patron request records. Drawing on scholarship from archival theorists and practitioners, as well as recent case studies and their own professional experience, the authors present a broad overview of the ethics and practice of privacy throughout the archival life cycle. At each stage, archivists seek a balance between sensitivity to the rights and well-being of creators and subjects and responsibility to researchers and the access mission. For archivists, privacy protections are not about secrecy or exclusivity, but about an ethics of care. Decisions made by archivists related to privacy have broad societal implications related to the understanding of history, the accountability of those in power, the availability of information, and the agency of creators and communities. We approach privacy from two complementary perspectives in archival practice—that of a collections manager and processing archivist working with creators, donors, and their archival collections to determine what privacy considerations may need to be addressed, and that of a reference and instruction archivist, working with students and researchers whose use of archival collections generates data that has its own privacy concerns.
Data Governance, Privacy, and Ethics
Authors: Schubert Karl D. , Barrett David 
Published: May 2024

AbstractWith the ever-increasing focus on artificial intelligence and use of nearly infinite information (data) available from an almost infinite number of sources (private, public, and government data bases; the web, etc.), understanding data governance, privacy, and ethics surrounding the availability and use of data is more important than ever. Nearly every day, new data breaches by and effecting individuals and organizations come to light. Nearly every day, new uses for data are envisioned and the ethical considerations around collection, storage, and use of these data are yet to be clearly thought out. The need for data governance to protect privacy and ensuring the ethical use of data is clear and there are many challenges to effectively define and implement effective data governance policies. And these must be implemented through legal and regulatory frameworks to be effective and enforceable. In this chapter, we will examine these topics including the challenges implementing effective data governance policies, the legal and regulatory frameworks governing data privacy and ethics, and a look to the future.
Storytelling as a Catalyst for Climate Change Communication and Empowerment
Authors: Wang Hua , Coren Emily 
Published: May 2024

AbstractIn this introductory chapter, we use storytelling as an umbrella term for any type, form, genre, and practice of narrative communication. After briefly reviewing the current scientific understanding of climate change, recent public opinions about the issue, and the international community’s efforts, we point out three critical and interrelated gaps in climate change communication and articulate how narrative strategies, especially entertainment-education for social and behavior change, can effectively inspire and mobilize individuals and communities worldwide to engage in climate action and empowerment.
Climate Fiction to Inspire Green Actions: A Tale of Two Authors
Authors: Baden Denise , Brown Jeremy 
Published: May 2024

AbstractMany works of ‘climate fiction’ have a tendency to depict an apocalyptic future that imagines a planet in dystopian collapse. While hope is that such cautionary tales will prompt constructive behavior change, unintended consequences can occur leaving some audiences feeling defensive, hostile, or overly anxious. In contrast, there is a body of evidence indicating that stories and characters that model positive solutions to climate change are more likely to inspire audiences to imitate the fictional role models. This positive approach is shared by the authors of this chapter—Denise Baden in her rom-com Habitat Man and Jeremy Brown (and team) in the comic series The Renegades: Defenders of the Planet. This chapter draws on their experience to offer advice to creative writers within climate fiction. While there are differences in the depiction of gentle versus radical solutions, both authors advocate the need for stories that generate a sense of agency, hope, and courage.
Three Ways to Introduce More Stories of Climate Action into Climate Change News Reporting
Authors: Whitwell Joe 
Published: May 2024

AbstractTraditional types of climate change news reporting can overwhelm, depress, and disempower readers. In this chapter, I propose three approaches to introduce more climate action-based storytelling to complement the traditional climate change news reporting. Firstly, we can tell these stories from across the newsroom and not just rely on the “science” or “climate” team. Secondly, we can engage with audiences to gather and share their own examples. Finally, we can take a systematic approach to incorporate stories of climate action at scale, by using technologies such as natural language templates that are reducing the cost of producing content while enhancing data-driven hyperlocal news reporting to promote human response and community engagement.
Community-Based Resilience: The Influence of Collective Efficacy and Positive Deviance on Climate Change-Related Mental Health
Authors: Cosentino Maya , Gal-Oz Roni , Safer Debra L. 
Published: May 2024

AbstractClimate change threatens not only physical well-being but also the mental health of individuals and communities. This chapter aims to provide examples and useful tools to create climate resilience in order to reduce harmful climate change-related mental health impacts. After reviewing the effects of climate change on health, the authors highlight the importance of social connection and resilience as mental health resources. The chapter then discusses how community-based resilience can be cultivated through social identity (i.e., perceiving oneself as belonging to social groups), collective efficacy (i.e., people’s shared beliefs about their group’s capability to accomplish collective tasks), and positive deviance (i.e., a behavior-change approach that amplifies the successful actions of existing community members). In addition, the chapter explores the potential for local, intentional community building to serve as an effective strategy to improve resilience. Finally, the specific examples of Cool Block and the Transition Town movement (e.g., Eco Vista) model how communities can effectively support climate change adaptation, mitigation, and resilience strategies.
Exploring Climate Science in the Metaverse: Interactive Storytelling in Immersive Environments for Deep Learning and Public Engagement
Authors: Spiegel Stacey , Wang Hua 
Published: May 2024

AbstractClimate science can be too complex for the general public to understand. By sharing several exemplary projects in this chapter, I hope to demonstrate how combining interactive storytelling in immersive environments with simulation, games, telepresence, social learning, and govies (a blend of movies with games) can provide mass audiences a deep learning experience about the natural world and issues related to the climate crisis. This approach offers participants extraordinary opportunities as scientific explorers to investigate real-world problems, present scientific information through live broadcast and pre-rendered videos projected on immersive cinema screens, and access media resources through individual touchscreen terminals and AI-driven voice-controlled interactions to participate in real-time group discussions in a shared space – physical and virtual – simultaneously. The metaverse is here, and the technological and social features of these immersive experiences hold tremendous value for public engagement with science education and climate communication.
Bird’s Eye View: Engaging Youth in Storying a Survivability Future through Performance and Interspecies Friendship
Authors: Osnes Beth , Hackett Chelsea , McDermott Molly T. , Safran Rebecca Jo 
Published: May 2024

AbstractBird’s Eye View is an art-science, informal learning project for youth engagement in storying our way beyond the climate crisis. The project is situated within the larger Side by Side initiative at the University of Colorado and was designed to lead a group of Boulder youth in observing and embodying birds through puppetry, costumes, and movement within multiple outdoor settings. Integral to this approach was the integration of equity and inclusion into environmental preservation. In this chapter, we share moments and highlights of our time spent alongside youth and birds in Side by Side during the summer of 2021. We connect this experience to the broader questions we face as a field: How can we create the rapid and lasting shifts needed to ensure our collective futures through creative climate narratives that can inspire action? How can we disrupt current ways of being and hierarchical models through interdisciplinary approaches? How can we story a new future? We offer our core findings as guideposts for our future work and for the collective efforts of all who work in informal learning spaces. Our findings center on the importance of fostering a sense of belonging through narratives of interspecies friendship that are created and performed by youth as a form of climate communication.
What We Need Now to Accelerate Climate Solutions through Storytelling
Authors: Coren Emily , Wang Hua 
Published: May 2024

AbstractIn this concluding chapter, we emphasize that the climate crisis deserves the use of all tools at our disposal to achieve the recommended mitigation and adaptation goals. Effective communication strategies are necessary to accelerate climate solutions at the required speed, scale, and scope, and they can be designed and implemented based on decades of research in behavior science. We elaborate on storytelling as a climate change communication and action strategy and highlight the power of narratives for social and behavioral change through popular entertainment. We especially advocate for the more rigorous approach of entertainment-education for social impact with better alignment across interdisciplinary partnerships, social objectives, narrative contents, communication platforms, linked resources, and program evaluations. Finally, we provide a tiered model with recommendations for actionable next steps to accelerate climate solutions.
Kembali Ke Hutan (Return to the Forest): Using Storytelling for Youth Engagement and Climate Action in Indonesia
Authors: Garg Ankur , Godfrey Anna , Eko Rosiana 
Published: May 2024

AbstractKnown as the “Lungs of the World,” Indonesia has some of the world’s highest proportion of forests and biodiversity. However, it also has one of the world’s largest carbon footprints, owing to the development needs and land use changes. BBC Media Action’s Kembali Ke Hutan (Return to the Forest) project aims to engage the millennials on the sustainable development challenges the country faces, help them to make informed choices, and create platforms to have their voices heard. To achieve this, we have co-produced an award-winning TV drama #CeritaKita (Our Story) with a companion social media discussion series Ngobrolin #CeritaKita (Chatter—Our Story), created a social media brand AksiKita Indonesia (Our Action), and partnered with media and civil society organizations for community engagement and capacity strengthening. This chapter outlines the project objectives, presents the program strategy, and details how research shaped the creative process. It also shares the planned evaluation.
Rhythm and Glue: An Entertainment-Education Prototype for Climate Communication
Authors: Coren Emily 
Published: May 2024

AbstractThis prototype of entertainment-education protocols is adapted for mainstream American audiences for climate change mitigation. The example demonstrates how entertainment-education can be used for creating community adaptation and resilience in supporting rapid transitions for sustainability. Using a narrative approach for climate communication, theRhythm and Gluestory emphasizes personal and collective efficacy, including layered examples of how climate change is already affecting the health of Americans. In the serial comedy drama,Rhythm and Glue, a Los Angeles community humorously learns to collaborate, sharing their skill sets to build a better city. Slapstick, romantic entanglements, and career advancement anchor the story, while real-time audience participation drives engagement with climate topics. Audience participation facilitates engagement increasing the capacity of existing climate mitigation programs. Each season presents an overarching climate change issue. Season One focuses on transportation transitions and the current health impacts of climate change, with subsequent seasons addressing; energy, water, food, and waste. The show highlights the realities of climate change facing residents of the United States and presents realistic solutions and behaviors that citizens can take to mitigate those effects, for themselves and their communities.
LOLs: Secret Weapon Against CFCs and CO2?
Authors: Gurney Celia , N’Diaye Mamoudou 
Published: May 2024

Abstract

Read This Chapter If You Do Not Want to Get F**ked

The climate crisis is serious, confusing, and has a lot of words people don’t understand. But everybody understands comedy! So, how do we weave these two very different fields together? Well, we don’t have to—it’s already happening. This chapter gives a brief overview of the history of entertainment-education; highlights research that demonstrates the efficacy of comedy as a communication strategy; details how various creators are using comedy to break down barriers to understanding how completely f**ked we are if we fail to build a more inclusive, justice-oriented clean energy economy; and explains what the climate change comedy field needs to move forward. If being completely f**ked is not on your agenda or the agenda of the future generations in your family, please read this chapter and join these collective efforts. Increased support and engagement could open doors for more mass media outlets, shows, and other entertainment projects to improve accessibility for the climate justice movement and invite more allies into it.
Introduction
Authors: Valarini Elizangela , De Oliveira Vanessa Elias , Trombini Maria Eugenia , Pohlmann Markus 
Published: May 2024

AbstractThe fight against corruption in Brazil has crossed national borders since 2014, gaining worldwide visibility with Lava Jato Operation, or Car Wash. This is due not only to the amount of money surrounding illegalities committed by political parties and representatives, elected or not, but also because large companies and businessmen were involved in a huge corruption scheme relating money and politics. The involvement of politicians and executives from several countries was also a hallmark of this corruption scandal. In addition, their confrontation involved an extensive effort by international anti-corruption agencies to track and recover the money of the Brazilian State. Like other Western democracies, Brazil was neither immune to misconduct and nor were its institutions ineffective in detecting it and pursuing legal accountability.
Compliance Implementation Challenges in the Shadow of Corporate Cime: A Case Study of Odebrecht S.A
Authors: Jorge Mario Helton 
Published: May 2024

ZusammenfassungWhen it comes to corporate crime, recent studies show that bribe givers are usually high-ranking, well-educated, and well-paid managers, which undertake risks in the name of the company and generally orientated toward growing and achieving results as a unit with the company. Until there is some sort of accountability, illegal actions are seen as useful to the organization and themselves. Corporate Crime encompasses the supply-side of corruption, which is associated with a firm’s interaction with the public sector, with cases of grand corruption, in contrast to petty corruption, being the most commonly studied, given its high-profile.
Oxidative Phenolic Coupling Reaction/Aza-Michael Reaction Strategy for the Synthesis of Complex Polycyclic Alkaloids
Authors: Odagi Minami , Nagasawa Kazuo 
Published: May 2024

AbstractThe synthesis of alkaloids featuring fused polycyclic frameworks has long attracted the interest of synthetic organic communities, owing to their great structural complexity and wide variety of biological activities. Indeed, a variety of strategies for synthesizing these alkaloids have been investigated over the years. Here, we present our innovative strategy for tahe construction of complex fused polycyclic frameworks via oxidative phenolic coupling reaction and subsequent regioselective intramolecular aza-Michael reaction. We illustrate its practical application in synthetic studies of amaryllidaceae alkaloids, and hasubanan alkaloids.
Total Synthesis of Amycolamicin
Authors: Meguro Yasuhiro , Enomoto Masaru , Kuwahara Shigefumi 
Published: May 2024

AbstractAmycolamicin (also called kibdelomycin) produced by two species of soil actinomycetes is a potent antibiotic against a broad range of drug-resistant bacteria with a novel binding mode to bacterial type II DNA topoisomerases and with no cross-resistance to existing antibacterial agents. The unique hybrid molecular architecture of amycolamicin attracted interest of many synthetic organic chemists and three total syntheses have been reported so far. In this chapter, we describe our total synthesis of amycolamicin in detail, which features a nucleophilic addition of a vinyllithiun reagent to an α-siloxy-β-alkoxy ketone to afford a tertiary alcohol as a single diastereomer, a highly diastereoselective intramolecular Diels–Alder reaction of a tetraenal with an unprotected hydroxy group to construct a trans-decalin unit incorporated in amycolamicin, an exclusively stereoconvergent N-acylation of an anomeric N-glycoside mixture bearing a cis-fused bicyclic carbonate system, and the exploitation of the cyclic carbonate as a vicinal diol protecting group and also as a masked β-hydroxy carbamate structure. Additionally, two other total syntheses accomplished by the Li and Baran groups as well as syntheses of partial structures of amycolamicin hitherto reported are also outlined in brief.