bluuebunny/crossref_metadata_2025_split huggingface dataset:
High levels of dietary fat impair glucose homeostasis in rainbow trout
Authors: Figueiredo-Silva A. Cláudia , Panserat Stéphane , Kaushik Sadasivam , Geurden Inge , Polakof Sergio 
Published: December 2011

SUMMARY
This study was designed to assess the effects of dietary fat levels on glucose homeostasis in rainbow trout under prolonged hyperglycaemia induced by high carbohydrate intake. Trout were fed identical amounts of one of two iso-energetic diets containing either a low (LFD, 3%) or a high fat level (HFD, 20%) and similar amounts of digestible carbohydrates (26–30%) for 14 days. While a single high fat meal reduced glycaemia compared with a low fat meal, the consumption of a high fat diet for 14 days resulted in prolonged hypergylcaemia and reduced plasma glucose clearance in response to an exogenous glucose or insulin challenge. The hyperglycaemic phenotype in trout was characterised by a reduction of the activities of lipogenic and glucose phosphorylating enzymes with a concomitant stimulation of enzymes involved in glucose production in the liver and reduced glycogen levels in the white muscle. Impaired glucose tolerance (IGT) was further associated with a significant reduction of insulin receptor substrate 1 (IRS1) protein content in muscle, and with a poor response of HFD fed fish to an exogenous insulin load, suggestive of impaired insulin signalling in trout fed with a HFD. To our knowledge, this is the first study showing that a teleost can also develop a high fat-induced IGT, characterised by persistent hyperglycaemia and reduced insulin sensitivity, established symptoms of IGT and the prediabetic insulin-resistant state in mammals. Our results also provide evidence that persistent hyperglycaemia after a high carbohydrate meal stems from a metabolic interaction between dietary macronutrients rather than from high carbohydrate intake alone.
Local acoustic particle motion guides sound-source localization behavior in the plainfin midshipman fish,Porichthys notatus
Authors: Zeddies David G. , Fay Richard R. , Gray Michael D. , Alderks Peter W. , Acob Andrew , Sisneros Joseph A. 
Published: December 2011

SUMMARYSound-source localization behavior was studied in the plainfin midshipman fish (Porichthys notatus) by making use of the naturally occurring phonotaxis response of gravid females to playback of the male's advertisement call. The observations took place outdoors in a circular concrete tank. A dipole sound projector was placed at the center of the tank and an 80–90 Hz tone (the approximate fundamental frequency to the male's advertisement call) was broadcast to gravid females that were released from alternative sites approximately 100 cm from the source. The phonotaxic responses of females to the source were recorded, analyzed and compared with the sound field. One release site was approximately along the vibratory axis of the dipole source, and the other was approximately orthogonal to the vibratory axis. The sound field in the tank was fully characterized through measurements of the sound pressure field using hydrophones and acoustic particle motion using an accelerometer. These measurements confirmed that the sound field was a nearly ideal dipole. When released along the dipole vibratory axis, the responding female fish took essentially straight paths to the source. However, when released approximately 90 deg to the source's vibratory axis, the responding females took highly curved paths to the source that were approximately in line with the local particle motion axes. These results indicate that the acoustic cues used by fish during sound-source localization include the axes of particle motion of the local sound field.
Triple-Negative Subtype Predicts Poor Overall Survival and High Locoregional Relapse in Inflammatory Breast Cancer
Authors: Li Jing , Gonzalez-Angulo Ana M. , Allen Pamela K. , Yu Tse K. , Woodward Wendy A. , Ueno Naoto T. , Lucci Anthony , Krishnamurthy Savitri , Gong Yun , Bondy Melissa L. , Yang Wei , Willey Jie S. , Cristofanilli Massimo , Valero Vicente , Buchholz Thomas A. 
Published: December 2011

Abstract

Background.
Numerous studies have demonstrated that expression of estrogen/progesterone receptor (ER/PR) and human epidermal growth factor receptor (HER)-2 is important for predicting overall survival (OS), distant relapse (DR), and locoregional relapse (LRR) in early and advanced breast cancer patients. However, these findings have not been confirmed for inflammatory breast cancer (IBC), which has different biological features than non-IBC.

Methods.
We retrospectively analyzed the records of 316 women who presented to MD Anderson Cancer Center in 1989–2008 with newly diagnosed IBC without distant metastases. Most patients received neoadjuvant chemotherapy, mastectomy, and postmastectomy radiation. Patients were grouped according to receptor status: ER+ (ER+/PR+ and HER-2−; n = 105), ER+HER-2+ (ER+/PR+ and HER-2+; n = 37), HER-2+ (ER−/PR− and HER-2+; n = 83), or triple-negative (TN) (ER−PR−HER-2−; n = 91). Kaplan–Meier and Cox proportional hazards methods were used to assess LRR, DR, and OS rates and their associations with prognostic factors.

Results.
The median age was 50 years (range, 24–83 years). The median follow-up time and median OS time for all patients were both 33 months. The 5-year actuarial OS rates were 58.7% for the entire cohort, 69.7% for ER+ patients, 73.5% for ER+HER-2+ patients, 54.0% for HER=2+ patients, and 42.7% for TN patients (p &lt; .0001); 5-year LRR rates were 20.3%, 8.0%, 12.6%, 22.6%, and 38.6%, respectively, for the four subgroups (p &lt; .0001); and 5-year DR rates were 45.5%, 28.8%, 50.1%, 52.1%, and 56.7%, respectively (p &lt; .001). OS and LRR rates were worse for TN patients than for any other subgroup (p &lt; .0001–.03).

Conclusions.
TN disease is associated with worse OS, DR, and LRR outcomes in IBC patients, indicating the need for developing new locoregional and systemic treatment strategies for patients with this aggressive subtype.
Cognitive Load Theory: What It Is, Why It's Important for Accounting Instruction and Research
Authors: Mostyn Gregory R. 
Published: December 2011

ABSTRACT
The purpose of this paper is to increase the awareness of accounting instructors, particularly those teaching introductory courses, of an important and relatively new development in cognitive psychology. This development, called cognitive load theory (CLT), both identifies the cognitive constraints of novice learners when learning complex tasks and also provides specific methods for improving learning efficiency. Despite extensive CLT research and its widespread application in the instructional design applications for many other fields, very little discussion has appeared in accounting education literature. This suggests not just an oversight, but also a great opportunity. This paper will present: (1) an overview of CLT and its use, (2) a brief history of recent learning theory and its effect on accounting education and the development of CLT, (3) a discussion of the key elements of CLT and its prescriptive research results for the classroom, and (4) suggestions for how CLT might benefit accounting research.
The Accounting Pilot and Bridge Project
Authors: Deines Dan S. , Bittner Joseph , Eichman Glenda 
Published: December 2011

ABSTRACT
The accounting profession will experience a 50 percent decline in its ranks in the next ten years as accounting professionals from the Baby Boomer generation retire. To replace these professionals, the accounting profession will have to compete with law, medicine, engineering, and other professions that will also be replacing their “boomers.” During the period the boomers are retiring, the number of high school graduates is expected to decline, which suggests that the currently high accounting enrollments are unlikely to continue. If the accounting profession is to compete for the best and brightest students in the future, it is in its best interest to address structural impediments that exist in its educational supply chain. One significant structural impediment in the supply chain is the traditional high school accounting course. In 2000 the AICPA's Taylor Report stated high school accounting courses were a “systemic barrier” to entry into the profession for the very high school students the profession wants to attract (Taylor 2000). These courses have not changed substantially since the Taylor report was issued. The Accounting Pilot and Bridge Project (The Project) proposes to eliminate this barrier and has created a new college-level high school accounting course that provides college credit for those students who take the course and pass a rigorous qualifying examination. The Project is modeled after the College Board's highly successful Advanced Placement (AP) program. Once specific goals are achieved, The Project plans to submit a proposal to the College Board for it to adopt accounting as part of its Advanced Placement curriculum. After describing the research and initiatives that led to the creation of The Project, this paper discusses the goals of The Project, the process to have accounting added to the College Board's AP Curriculum, the curriculum used in the pilot course, the progress made to date, and what lies ahead.
The imprints of superstatistics in multiparticle production processes
Authors: Wilk Grzegorz , Włodarczyk Zbigniew 
Published: December 2011

AbstractWe provide an update of the overview of imprints of Tsallis nonextensive statistics seen in a multiparticle production processes. They reveal an ubiquitous presence of power law distributions of different variables characterized by the nonextensivity parameter q > 1. In nuclear collisions one additionally observes a q-dependence of the multiplicity fluctuations reflecting the finiteness of the hadronizing source. We present sum rules connecting parameters q obtained from an analysis of different observables, which allows us to combine different kinds of fluctuations seen in the data and analyze an ensemble in which the energy (E), temperature (T) and multiplicity (N) can all fluctuate. This results in a generalization of the so called Lindhard’s thermodynamic uncertainty relation. Finally, based on the example of nucleus-nucleus collisions (treated as a quasi-superposition of nucleon-nucleon collisions) we demonstrate that, for the standard Tsallis entropy with degree of nonextensivity q < 1, the corresponding standard Tsallis distribution is described by q′ = 2 − q > 1.
A model of axonal transport drug delivery
Authors: Kuznetsov Andrey 
Published: December 2011

Abstract
In this paper a model of targeted drug delivery by means of active (motor-driven) axonal transport is developed. The model is motivated by recent experimental research by Filler et al. (A.G. Filler, G.T. Whiteside, M. Bacon, M. Frederickson, F.A. Howe, M.D. Rabinowitz, A.J. Sokoloff, T.W. Deacon, C. Abell, R. Munglani, J.R. Griffiths, B.A. Bell, A.M.L. Lever, Tri-partite complex for axonal transport drug delivery achieves pharmacological effect, Bmc Neuroscience 11 (2010) 8) that reported synthesis and pharmacological efficiency tests of a tri-partite complex designed for axonal transport drug delivery. The developed model accounts for two populations of pharmaceutical agent complexes (PACs): PACs that are transported retrogradely by dynein motors and PACs that are accumulated in the axon at the Nodes of Ranvier. The transitions between these two populations of PACs are described by first-order reactions. An analytical solution of the coupled system of transient equations describing conservations of these two populations of PACs is obtained by using Laplace transform. Numerical results for various combinations of parameter values are presented and their physical significance is discussed.
Impact of a Longitudinal Community HIV Intervention Targeting Injecting Drug Users' Stage of Change for Condom and Bleach Use
Authors: Jamner Margaret Schneider , Wolitski Richard J. , Corby Nancy H. 
Published: December 2011

Purpose. To evaluate the impact of the Long Beach AIDS Community Demonstration Project, a community-based HIV-prevention intervention incorporating principles from the Transtheoretical model in its design and evaluation. Design. Repeated cross-sectional sampling with matched intervention and comparison communities. Setting. Neighborhoods in Long Beach, California, having a high prevalence of drug abuse and prostitution. Subjects. 3081 injecting drug users who were sexually active and/or shared injection equipment. Intervention. Trained peer volunteers distributed fliers featuring role model stories targeted to the population's stage of change. Fliers were packaged with bleaching kits and/or condoms. Measures. Primary outcome measures were exposure to the intervention, condom carrying, and stage of change for disinfecting injection equipment with bleach and for using condoms with main and other partners. Results. Toward the end of the study, 77% of injection drug users in the intervention area reported being exposed to the intervention. In the intervention area, rates of condom carrying increased from 10 to 27% (p <.001), and there was an increase from 2.32 to 3.11 in mean stage of change for using condoms with other partners, while stage of change decreased in the comparison area (p <.01). Mean stage of change for using condoms with a main partner also increased in the intervention area, but the difference was not significant after controlling for change in the comparison area. Subjects with recent project exposure had higher stage-of-change scores for using condoms with a main partner (p <.05) and other partners (p <.01) and for cleaning injection equipment with bleach (p <.05). Conclusions. The results demonstrate the effectiveness of the AIDS Community Demonstration Project intervention for reaching injecting drug users in the community and for motivating the adoption of risk-reducing practices.
Stages of Change and Psychosocial Correlates of Fruit and Vegetable Consumption among Rural African-American Church Members
Authors: Campbell Marci Kramish , Symons Michael , Demark-Wahnefried Wendy , Polhamus Barbara , Bernhardt Jay M. , McClelland Jacquelyn W. , Washington Chanetta 
Published: December 2011

Purpose. This study examined the relationship between stages of change, other psychosocial factors, and fruit and vegetable (F&V) consumption among rural African-Americans participating in a 5 a Day study. Design. The cross-sectional design assessed associations between F&V intake, stage of change, self-efficacy, beliefs, barriers, and social support. Setting. Participants were surveyed by telephone. Subjects. Subjects were 3557 adult church members (response rate, 79.1%), aged 18 and over from 10 North Carolina counties. Measures. A seven-item food frequency measured F&V intake. Stage of change was measured using four items; other psychosocial variables were measured using Likert scales. Chi-square tests and analysis of variance were used in statistical analyses. Results. The majority of participants (65 %) were in the preparation stage of change. Individuals in action/maintenance consumed an average of 6.5 daily F&V servings compared to 3.3 to 3.5 servings for those in precontemplation, contemplation, and preparation. Self-efficacy, social support, and belief about how many daily F&V servings are needed, were positively associated with stage. Barriers were most prevalent among precontemplators. Conclusions. The findings support the applicability of the stages-of-change model to dietary change among rural African-Americans. The relationship between stage, self-efficacy, social support, and barriers supports using a multicomponent intervention strategy.
A Review of the Health Impact of Smoking Control at the Workplace
Authors: Eriksen Michael P. , Gottlieb Nell H. 
Published: December 2011

Purpose. To summarize and provide a critical review of worksite health promotion program evaluations published between 1968 and 1994 that addressed the health impact of worksite smoking cessation programs and smoking policies. Methods. A comprehensive literature search conducted under the auspices of the Centers for Disease Control and Prevention identified 53 smoking cessation program evaluation reports, of which 41 covered worksite single-topic cessation programs. Nine additional reports were located through manual search of citations from published reports and reviews. These 50 reports covered 52 original data-based studies of cessation programs. The search produced 19 reports for tobacco policy evaluations, of which 12 addressed health impact. An additional 17 reports were located by the authors. These 29 reports covered 29 studies of policy impact. Summary of Important Findings. Smoking cessation group programs were found to be more effective than minimal treatment programs, although less intensive treatment, when combined with high participation rates, can influence the total population. Tobacco policies were found to reduce cigarette consumption at work and worksite environmental tobacco smoke (ETS) exposure. Conclusions. The literature is rated suggestive for group and incentive interventions; indicative for minimal interventions, competitions, and medical interventions; and acceptable for the testing of incremental effects. Because of the lack of experimental control, the smoking policy literature is rated as weak, although there is strong consistency in results for reduced cigarette consumption and decreased exposure to ETS at work.
The perceived personal control (PPC) questionnaire: Reliability and validity in a sample from the United Kingdom
Authors: McAllister Marion , Wood Alex M. , Dunn Graham , Shiloh Shoshana , Todd Chris 
Published: December 2011

AbstractOutcome measures are important assessment tools to evaluate clinical genetics services. Research suggests that perceived personal control (PPC) is an outcome valued by clinical genetics patients and clinicians. The PPC scale was developed in Hebrew to capture three dimensions of PPC: Cognitive, decisional, and behavioral control. This article reports on the first psychometric validation of the English translation of the PPC scale. Previous research has shown that the Hebrew and Dutch translations have good psychometric properties. However, the psychometric properties of the English translation have not been tested, and there is disagreement about the factor structure, with implications for how to score the measure. A total of 395 patients attending a clinical genetics appointment in the United Kingdom completed several measures at baseline, and a further 241 also completed measures at 2–4 weeks follow‐up. The English language PPC has (a) a one‐factor structure, (b) convergent validity with internal health locus of control (IHLC), satisfaction with life (SWL), depression, and authenticity, (c) high internal consistency (α = 0.83), and (d) sensitivity to change, being able to identify moderate changes in PPC following clinic attendance (Cohen's d = 0.40). These properties suggest the English language PPC measure is a useful tool for both clinical genetics research and for use as a Patient Reported Outcome Measure (PROM) in service evaluation. © 2011 Wiley Periodicals, Inc.
The prevalence of sleepiness and the risk of sleep‐disordered breathing in children with positive allergy test
Authors: Ishman Stacey L. , Smith David F. , Benke James R. , Nguyen Mai‐Tien , Lin Sandra Y. 
Published: December 2011

AbstractBackground:We evaluated the prevalence of sleep‐disordered breathing (SDB) and sleepiness in children with allergy and compared sleep‐specific quality of life measures to those of children without allergy.Methods:A prospective case‐control study was done at a tertiary care academic center. The parents of 21 pediatric patients with positive environmental allergy testing completed questionnaires including the Obstructive Sleep Apnea‐18 (OSA18), the Pediatric Sleep Questionnaire (PSQ), and the Pediatric Daytime Sleepiness Scale (PDSS). Comparisons were made to 113 children without allergy who had undergone cochlear implantation (CI) who served as controls.Results:SDB was suggested in 19% of children with allergy using the OSA18 and in 29% using the PSQ vs 6% and 7% of controls (p = 0.029; p = 0.003), respectively. In addition, daytime sleepiness was suggested in 45% to 48% of children with allergy using the PSQ and PDSS vs 17% to 25% of controls (p = 0.015; p = 0.025), respectively. Patients with allergy had SDB and sleepiness scores higher than population normal values: OSA‐18 of 41.7 vs 34.0, PSQ‐SDB of 0.25 vs 0.14, PSQ‐Sleepy of 0.34 vs 0.15, and PDSS of 14.2 vs 11.4. The difference between cases and controls was significant for all measures of sleepiness and SDB.Conclusion:Children with allergy have higher SDB and sleepiness scores than controls. This suggests that children with allergic rhinitis are at increased risk for SDB and screening should be considered in this population. In addition, studies with a larger sample size are important to fully understand this relationship. © 2011 ARS‐AAOA, LLC.
DNA Origami: The Art of Folding DNA
Authors: Saccà Barbara , Niemeyer Christof M. 
Published: December 2011

AbstractThe advent of DNA origami technology greatly simplified the design and construction of nanometer‐sized DNA objects. The self‐assembly of a DNA‐origami structure is a straightforward process in which a long single‐stranded scaffold (often from the phage M13mp18) is folded into basically any desired shape with the help of a multitude of short helper strands. This approach enables the ready generation of objects with an addressable surface area of a few thousand nm2 and with a single “pixel” resolution of about 6 nm. The process is rapid, puts low demands on experimental conditions, and delivers target products in high yields. These features make DNA origami the method of choice in structural DNA nanotechnology when two‐ and three‐dimensional objects are desired. This Minireview summarizes recent advances in the design of DNA origami nanostructures, which open the door to numerous exciting applications.
Polyelectrolyte‐aided synthesis of gold and platinum nanoparticles: Implications in electrocatalysis and sensing
Authors: Rao Chepuri R. K. 
Published: December 2011

AbstractAn electrochemical method for depositing redispersible, lower size gold nanoparticles from a novel polyelectrolyte‐gold complex is described. The size of gold nanoparticles is in the range 6.2–15.4 nm. The gold nanoparticles, first deposited on platinum surface are transferable into water. They can also be directly in situ‐electrodeposited on to materials like carbon, carbon nanotubes or conducting polymers for an end use as electro catalysts. The composites Au‐MWCNT, Pt‐MWCNT, Au‐Carbon, and Pt‐Carbon are synthesized and tested for their electrocatalytic activity. The composites exhibit good catalytic activity in sensing dopamine or electrooxidation of methanol. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Modeling of the compaction response of jute fabrics in liquid composite molding processes
Authors: Francucci Gastón , Rodríguez Exequiel S. 
Published: December 2011

AbstractIn this work, the experimental data of the compaction behavior of jute woven fabrics obtained in a previous work were modeled. A brief description of the current theoretical models found in literature is presented. It was concluded that these theoretical models cannot be used on natural fiber fabrics due to the vast differences in fiber structure and fibers assembly among natural and synthetic fibers. Therefore, two empirical models commonly seen in literature were used to fit the experimental data: the power law and the exponential function. In addition, a novel model was proposed, which represented much better the compaction behavior of the fabrics. The stress relaxation was also modeled using three empirical models: a power law, a first‐order exponential function, and a second‐order exponential function. The two‐parameter power law model fitted the relaxation curve as well as the five‐parameter exponential function. On the other hand, the first‐order exponential function could not represent properly the relaxation stage. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011