bluuebunny/crossref_metadata_2025_split huggingface dataset:
YouTube: An emerging tool in anatomy education
Authors: Jaffar Akram Abood 
Published: March 2012

AbstractThe use of online social networks in medical education can remodel and enhance anatomy teaching and learning; one such network is the video‐sharing site YouTube. Limited research in the literature exists on the use of YouTube as a platform for anatomy education. The aim of this study is to assess student's perceptions and patterns of usage of this resource, as well as the effectiveness of YouTube videos within a problem‐based learning (PBL) curriculum. The study was conducted on 91 second‐year medical students for whom video links were suggested throughout the academic year. In addition, the Human Anatomy Education (HAE) Channel was launched on YouTube to support classroom teaching with videos that emphasized applied aspects of anatomy. The results demonstrated that 98% of the students used YouTube as an online information resource, albeit in different frequencies. Out of the 86% who have been to the HAE Channel, 92% agreed/strongly agreed that the channel helped them learn anatomy. The study also reports the popularity of and awareness about using YouTube as a social network as well as in learning. Based on these findings, YouTube can be considered as an effective tool to enhance anatomy instruction if the videos are scrutinized, diversified, and aimed toward course objectives. Faculty of average computer literacy should be enabled to produce videos on their own YouTube channels to support independent learning and integration in a PBL curriculum. The methods described for capturing and editing the videos can be used as a prototype. Anat Sci Educ. © 2012 American Association of Anatomists.
Iodine(III)‐Promoted Intermolecular Diamination of Alkenes
Authors: Souto José A. , González Yolanda , Iglesias Alvaro , Zian Debora , Lishchynskyi Anton , Muñiz Kilian 
Published: March 2012

AbstractA rapid and productive vicinal diamination of alkenes takes place in the presence of a hypervalent iodine(III) reagent and bissulfonimides as nitrogen sources. A total of more than 60 examples are presented. The reaction is characterized by its robustness and its wide substrate scope: it proceeds selectively with both terminal and internal alkenes and tolerates a range of functional groups.
Dynamic marginal cost, access control, and pollution charge: a comparison of bottleneck and whole link models
Authors: Zhong Renxin , Sumalee Agachai , Maruyama Takuya 
Published: March 2012

SUMMARYIn this paper, we investigate theoretical constructions and properties of three interrelated travel demand management measures including marginal cost pricing, access control, and pollution charge under dynamic traffic assignment framework. For congested traffic networks modeled by the two vertical queue models, that is, the whole link model and the deterministic queuing model, on which flows are controlled, we derive dynamic marginal costs for paths and users' external costs for controlled links. As a strategy to implement the access control, the access pricing is formulated as a dynamic system optimal assignment with access (e.g., traffic volume, queue) control problem, wherein the access constraints represent the restrictions on the traffic volumes and/or environmental constraints. For the whole link model case, an optimal control problem formulation is adopted to investigate the dynamic traffic equilibrium. We derive and discuss the necessary condition for operating the transportation system with capacity/environmental constraints optimally. For the deterministic queuing model case, the inflow to a bottleneck is saturated such that no queue would be formed. The dynamic externalities of the two models are compared. It is found that different externality structures of the two models result in different tolling structures to achieve dynamic system optimal assignment. On the basis of this access pricing analysis and an “equivalent” environmental capacity that converts the environmental constraint into traffic volume restriction, we investigate the traffic‐induced air pollution pricing scheme. Copyright © 2012 John Wiley & Sons, Ltd.
Vorgespannte Fertigteile aus Ultrahochfestem Faserbeton
Authors: Zimmermann Welf , Sparowitz Lutz 
Published: March 2012

AbstractSeit der Jahrtausendwende können Bauingenieure bei ihren Objektplanungen den Baustoff Beton in der Form von Ultrahochfestem Beton (UHPC) bzw. Ultrahochfestem Faserbeton (UHPFRC) bei praktischen Bauvorhaben anwenden. Die wissenschaftliche Forschung und materialtechnologische Entwicklung für diesen neuartigen und innovativen Baustoff ist seit diesem Zeitpunkt als Grundlage für Planungen, Ausschreibungen und den praktischen Baustelleneinsatz weitgehend vorhanden. Die ersten Aktivitäten mit ultrahochfestem Beton in Österreich begannen in den Jahren 2005 und 2006 im Süden Österreichs in den Bundesländern Kärnten und Steiermark auf Initiative des Institutes für Betonbau an der TU Graz. Der Schwerpunkt wurde dabei auf die praktische Anwendung für die konstruktive Planung und Bauausführung auf Baustellen gelegt, obwohl es in Österreich derzeit weder anwendbare Normen oder Richtlinien dafür gibt. Die ersten praktischen Anwendungen in Österreich waren Brücken, die mit Unterstützung der Kärntner Landesregierung entstanden. Man erkannte, dass das Material UHPC besonders für die Fertigteilbauweise geeignet ist, weshalb die ersten Brückenkonstruktionen vorwiegend aus Fertigteilen in Kombination mit Spanngliedern geplant und gebaut wurden. Dabei konnte gezeigt werden, dass ein sinnvoller Einsatz eines neuen, aber auch teuren Hochleistungswerkstoffes mithilfe von modernen Montagemethoden wie z. B. dem Segmentklappverfahren dennoch zu wirtschaftlichen, wartungsarmen und architektonisch anspruchsvollen Bauwerken mit langer Lebensdauer führen kann.
Die Seitenhafenbrücke in Wien
Authors: Kral Helmut , Kuhnle Thomas , Spindlböck Stephan , Kolik Georg 
Published: March 2012

AbstractIm November 2011 übergab die Wiener Magistratsabteilung 29 Brückenbau und Grundbau die Seitenhafenbrücke über den Donaukanal dem Verkehr, um den wirtschaftlich aufstrebenden Wiener Hafen an das Wiener Hauptverkehrsnetz anzubinden. Die Seitenhafenbrücke besticht durch ihre schlanke vorgespannte Betonplatte in den Außenfeldern sowie den Plattenbalken im Mittelfeld, die auf V‐förmigen Stahlstreben gelagert sind. Herausfordernd war die Umsetzung der überaus komplexen Rahmenbedingungen, die aus den Anforderungen aus dem Straßenprojekt und den einzuhaltenden Lichtraumprofilen der Schifffahrt sowie der ufernahen Begleitwege resultierten. Die Brücke als integrales Bauwerk vereint die Vorteile des wartungsminimierenden Entfalls von stählernen Fahrbahnübergängen und Lagern. Gussknoten – präzise für die Anforderungen entwickelt – leiten die Auflagerlasten in die Fundamente und erfüllen alle Anforderungen an Lasteinleitung und Langlebigkeit des Tragwerks. Die Seitenhafenbrücke mit einer Gesamtlänge von ca. 130 m gewährleistet damit zukünftig die Anbindung des Wiener Hafens an die Ost‐Verbindung auf dem Straßenwege und besticht den Schifffahrtsgast auf dem Donaukanal durch eine aufgelöste und dem statischen Kräftefluss entsprechende Inszenierung der Untersicht.
Nachträgliche Verankerung von Querspanngliedern
Authors: Fust Christina , Wolff Maren , Mark Peter , Borowski Michael 
Published: March 2012

AbstractFür den abschnittsweisen Ersatzneubau der Deelbögebrücke wurde in Zusammenarbeit zwischen dem Landesbetrieb Straßen, Brücken und Gewässer Hamburg (LSBG), dem Ingenieurbüro Grassl und dem Lehrstuhl für Massivbau der Ruhr‐Universität Bochum ein Verfahren zur nachträglichen Zwischenverankerung von Querspanngliedern entwickelt. Dieses ermöglicht den Erhalt eines Teils der Brücke für eine ungestörte Verkehrsführung während der Bauzeit. Eine Stahlklemmkonstruktion überträgt über Reibschluss die freiwerdende Vorspannkraft und leitet sie über Druckkräfte in den verbleiben Überbau wieder ein. Der Beitrag zeigt den Entwurf für den Rückbau, die Entwicklung und experimentelle Untersuchung der Stahlklemmkonstruktion und die erfolgreiche Umsetzung der Baumaßnahme.Subsequent anchorage of transverse prestressing cables clamping devices to rebuild Deelböge BridgeIn a collaboration of the Agency of Roads, Bridges and Waters of the Free and Hanseatic City of Hamburg (LSBG), the Grassl Consultant Engineers and the Institute of Concrete Structures at the Ruhr‐University of Bochum, a clamping device to subsequently anchor transverse prestressing bars is developed. It transfers the released prestressing forces via shear friction to clamping steel plates and then by direct compressive contact to the surrounding concrete. The device is applied to stepwise rebuild the Deelböge Bridge in Hamburg continuously ensuring an ongoing traffic on one side of the bridge during building activities. The contribution lays out the conceptual design of the bridge rebuilt, the theoretical and technical elaboration of the clamping device as well as its successful application on site.
Cloning and characterization of a panel of constitutive promoters for applications in pathway engineering in Saccharomyces cerevisiae
Authors: Sun Jie , Shao Zengyi , Zhao Hua , Nair Nikhil , Wen Fei , Xu Jian‐He , Zhao Huimin 
Published: March 2012

AbstractSaccharomyces cerevisiae is an important platform organism for synthesis of chemicals and fuels. However, the promoters used in most pathway engineering studies in S. cerevisiae have not been characterized and compared in parallel under multiple conditions that are routinely operated in laboratory and the number of known promoters is rather limited for the construction of large biochemical pathways. Here a total of 14 constitutive promoters from S. cerevisiae were cloned and characterized using a green fluorescent protein (GFP) as a reporter in a 2 µ vector pRS426, under varying glucose and oxygen concentrations. The strengths of these promoters varied no more than sixfold in the mean fluorescence intensity of GFP, with promoter TEF1p being the strongest and promoter PGI1p the weakest. As an example of application for these promoters in metabolic engineering, the genes involved in xylan degradation and zeaxanthin biosynthesis were subsequently cloned under the control of promoters with medium to high strength and assembled into a single pathway. The corresponding construct was transformed to a S. cerevisiae strain integrated with a D‐xylose utilizing pathway. The resulting strain produced zeaxanthin with a titer of 0.74 ± 0.02 mg/L directly from birchwood xylan. Biotechnol. Bioeng. 2012; 109:2082–2092. © 2012 Wiley Periodicals, Inc.
Use of focused acoustics for cell disruption to provide ultra scale‐down insights of microbial homogenization and its bioprocess impact—recovery of antibody fragments from rec E. coli
Authors: Li Qiang , Aucamp Jean P. , Tang Alison , Chatel Alex , Hoare Mike 
Published: March 2012

AbstractAn ultra scale‐down (USD) device that provides insight of how industrial homogenization impacts bioprocess performance is desirable in the biopharmaceutical industry, especially at the early stage of process development where only a small quantity of material is available. In this work, we assess the effectiveness of focused acoustics as the basis of an USD cell disruption method to mimic and study high‐pressure, step‐wise homogenization of rec Escherichia coli cells for the recovery of an intracellular protein, antibody fragment (Fab′). The release of both Fab′ and of overall protein follows first‐order reaction kinetics with respect to time of exposure to focused acoustics. The rate constant is directly proportional to applied electrical power input per unit volume. For nearly total protein or Fab′ release (>99%), the key physical properties of the disruptate produced by focused acoustics, such as cell debris particle size distribution and apparent viscosity show good agreement with those for homogenates produced by high‐pressure homogenization operated to give the same fractional release. The only key difference is observed for partial disruption of cells where focused acoustics yields a disruptate of lower viscosity than homogenization, evidently due to a greater extent of polynucleic acids degradation. Verification of this USD approach to cell disruption by high‐pressure homogenization is achieved using USD centrifugation to demonstrate the same sedimentation characteristics of disruptates prepared using both the scaled‐down focused acoustic and the pilot‐scale homogenization methods for the same fraction of protein release. Biotechnol. Bioeng. 2012; 109:2059–2069. © 2012 Wiley Periodicals, Inc.
Detection of 22 antiepileptic drugs by ultra‐performance liquid chromatography coupled with tandem mass spectrometry applicable to routine therapeutic drug monitoring
Authors: Shibata Mai , Hashi Sachiyo , Nakanishi Haruka , Masuda Satohiro , Katsura Toshiya , Yano Ikuko 
Published: March 2012

ABSTRACTThe purpose of this study was to develop an ultra‐performance liquid chromatography tandem mass spectrometry (UPLC‐MS/MS) method of 22 antiepileptics for routine therapeutic monitoring. The antiepileptics used in the analyses were carbamazepine, carbamazepine‐10,11‐epoxide, clobazam, N‐desmethylclobazam, clonazepam, diazepam, N‐desmethyldiazepam, ethosuximide, felbamate, gabapentin, lamotrigine, levetiracetam, N‐desmethylmesuximide, nitrazepam, phenobarbital, phenytoin, primidone, tiagabine, topiramate, valproic acid, vigabatrin and zonisamide. After protein precipitation of 50 μL plasma with methanol, the supernatant was diluted with water or was evaporated to dryness and reconstituted with mobile phase in the case of benzodiazepines. Separation was achieved on an Acquity UPLC BEH C18 column with a gradient mobile phase of 10 mm ammonium acetate containing 0.1% formic acid and methanol at a flow rate of 0.4 mL/min. An Acquity TQD instrument in multiple reaction monitoring mode with ion mode switching was used for detection. All antiepileptics were detected and quantified within 10 min, with no endogenous interference. All the calibration curves showed good linearity in the therapeutic range (r2 < 0.99). The precision and accuracy values for intra‐ and inter‐assays were within ±15% except for phenobarbital and tiagabine. A good correlation was observed between the concentration of clinical samples measured by the new method described here and the conventional methods. The values of carbamazepine and phenytoin by UPLC‐MS/MS were lower than those detected by the immunoassays, which might be caused by the cross‐reaction of antibodies with their metabolites. In conclusion, we developed a simple and selective UPLC‐MS/MS method suitable for routine therapeutic monitoring of antiepileptics. Copyright © 2012 John Wiley & Sons, Ltd.
The Carmaphycins: New Proteasome Inhibitors Exhibiting an α,β‐Epoxyketone Warhead from a Marine Cyanobacterium
Authors: Pereira Alban R. , Kale Andrew J. , Fenley Andrew T. , Byrum Tara , Debonsi Hosana M. , Gilson Michael K. , Valeriote Frederick A. , Moore Bradley S. , Gerwick William H. 
Published: March 2012

AbstractTwo new peptidic proteasome inhibitors were isolated as trace components from a Curaçao collection of the marine cyanobacterium Symploca sp. Carmaphycin A (1) and carmaphycin B (2) feature a leucine‐derived α,β‐epoxyketone warhead directly connected to either methionine sulfoxide or methionine sulfone. Their structures were elucidated on the basis of extensive NMR and MS analyses and confirmed by total synthesis, which in turn provided more material for further biological evaluations. Pure carmaphycins A and B were found to inhibit the β5 subunit (chymotrypsin‐like activity) of the S. cerevisiae 20S proteasome in the low nanomolar range. Additionally, they exhibited strong cytotoxicity to lung and colon cancer cell lines, as well as exquisite antiproliferative effects in the NCI60 cell‐line panel. These assay results as well as initial structural biology studies suggest a distinctive binding mode for these new inhibitors.
Catalyst Recovery and Recycling Facilitated by Magnetic Separation: Iridium and Other Metal Nanoparticles
Authors: Jacinto Marcos J. , Silva Fernanda P. , Kiyohara Pedro K. , Landers Richard , Rossi Liane M. 
Published: March 2012

AbstractThe immobilization of metal nanoparticles in magnetic responsive solids allows the easy, fast, and clean separation of catalysts; however, the efficiency of this separation process depends on a strong metal–support interaction. This interaction can be enhanced by functionalizing the support surface with amino groups. Our catalyst support contains an inner core of magnetite that enables the magnetic separation from liquid systems and an external surface of silica suitable for further modification with organosilanes. We report herein that a magnetically recoverable amino‐functionalized support captured iridium species from liquid solutions and produced a highly active hydrogenation catalyst with negligible metal leaching. An analogous Ir0catalyst prepared with use of a nonfunctionalized support shows a higher degree of metal leaching into the liquid products. The catalytic performance in the hydrogenation of alkenes is compared with that of Rh and Pt catalysts.
Promotional Effect of Ni in the Selective Gas‐Phase Hydrogenation of Chloronitrobenzene over Cu‐based Catalysts
Authors: Cárdenas‐Lizana Fernando , Bridier Blaise , Shin Choong Catherine Kai , Pérez‐Ramírez Javier , Kiwi‐Minsker Lioubov 
Published: March 2012

AbstractWe present 100 % selectivity to p‐chloroaniline through the continuous gas‐phase (atmospheric pressure; T=393–523 K) catalytic hydrogenation of p‐chloronitrobenzene over an activated CuAl (molar Cu/Al ratio 3:1) hydrotalcite. The synthesis by continuous co‐precipitation and application of a CuNiAl (atomic Cu/Ni/Al ratio 2.75:0.25:1) catalyst is also described. Temperature‐programmed reduction in hydrogen and XPS analyses of the ternary catalyst suggest CuNi interaction with no evidence of (bulk) alloy formation (based on XRD). Under the same reaction conditions, CuNiAl exhibited a higher (by up to a two‐fold) hydrogenation rate when compared to CuAl, while the exclusive nitro‐group reduction was maintained.
ChemInform Abstract: Quenching of the Luminescence of Upconverting Luminescent Nanoparticles by Heavy Metal Ions.
Authors: Saleh Sayed M. , Ali Reham , Wolfbeis Otto S. 
Published: March 2012

AbstractLuminescence quenching of upconverting luminescent lanthanoid‐doped NaYF4 nanocrystals by CuII, HgII, PbII, CdII, CoII, AgI, FeIII, ZnII, bromide, and iodide ions is investigated.
ChemInform Abstract: Synthesis and X‐Ray Photoelectron Spectroscopy (XPS) and Thermoelectric Studies of Ternary Bi2(Te0.5Se0.5)3 Mixed‐Metal Chalcogenide Thin Films by the Arrested Precipitation Technique.
Authors: Patil S. M. , Mane S. R. , Mane R. M. , Mali S. S. , Patil P. S. , Bhosale P. N. 
Published: March 2012

AbstractBi2(Te0.5Se0.5)3 thin films are deposited on glass substrates by the arrested precipitation technique using Bi(NO3)3, Na2SeSO3, Na2TeSO3, and Et3N as starting materials (pH 10.5, 55 °C, 1.5 h).
ChemInform Abstract: Synthesis, Characterization and Application of Carbon Nanocages as Anode Materials for High‐Performance Lithium‐Ion Batteries.
Authors: Li Guangda , Xu Liqiang , Hao Qin , Wang Meng , Qian Yitai 
Published: March 2012

AbstractCarbon nanocages (CNCs) with diameters of about 200—500 nm are synthesized from mixtures of citric acid and nickel oxalate (autoclave, 550 °C, 12 h).
ChemInform Abstract: Recycling ZnTe, CdTe, and Other Compound Semiconductors by Ambipolar Electrolysis.
Authors: Bradwell David J. , Osswald Sebastian , Wei Weifeng , Barriga Salvador A. , Ceder Gerbrand , Sadoway Donald R. 
Published: March 2012

AbstractElectrolysis of ZnTe—ZnCl2 melts (500 °C) results in the production of phase‐pure liquid Zn and liquid Te.
ChemInform Abstract: Microporous Aluminoborates with Large Channels: Structural and Catalytic Properties.
Authors: Martin‐Matute Belen , et al. et al. 
Published: March 2012

AbstractAl2B5O9 (OH)3·nH2O (I) is synthesized from a mixture of AlCl3·6H2O and H3BO3 (autoclave, 240 °C, 15 d, 90% yield).
ChemInform Abstract: Intermetallic Cadmium Compounds M5T2Cd (M: Ca, Yb, Eu; T: Cu, Ag, Au) with Mo5B2Si‐Type Structure.
Authors: Tappe Frank , Schwickert Christian , Eul Matthias , Poettgen Rainer 
Published: March 2012

AbstractThe title compounds and Yb5Cu2Zn are prepared by melting of the elements (sealed Ta tubes) followed by annealing at 923 K for 3 h.
ChemInform Abstract: One‐Step Solution Synthesis of Bismuth Sulfide (Bi2S3) with Various Hierarchical Architectures and Their Photoresponse Properties.
Authors: Xiao Guanjun , Dong Qingfeng , Wang Yingnan , Sui Yongming , Ning Jiajia , Liu Zhaoyang , Tian Wenjing , Liu Bingbing , Zou Guangtian , Zou Bo 
Published: March 2012

AbstractThe title compound is synthesized from a mixture of Bi(OAc)3, sulfur in 1‐octadecene, and oleic acid (180 °C, 2 h).
ChemInform Abstract: pH‐Dependent Assembly of Reduced Polyoxomolybdenum Phosphates Modified by MnII.
Authors: Lu Jing , Liu Hou‐Ting , Song Hao , Wang Su‐Na , Wang Da‐Qi , Zhang Xian‐Xi 
Published: March 2012

AbstractCompound (III) is obtained at pH 3 with (enH2)2 [H2P2Mo5O23] (9% yield) as byproduct and at pH 5 with (enH2)3(enH)2 [H2P2Mo5O23] 2·10H2O as byproduct.
ChemInform Abstract: Mixed Crystal Formation and Structural Studies in the Mullite‐Type System Bi2Fe4O9—Bi2Mn4 O10.
Authors: Kann Zachary R. , Auletta Jeffrey T. , Hearn Eric W. , Weber Sven‐U. , Becker Klaus D. , Schneider Hartmut , Lufaso Michael W. 
Published: March 2012

AbstractSamples of the title system are prepared by solid state reaction of Bi2O3, MnO2, and Fe2O3 (825 °C).
ChemInform Abstract: The New High‐Pressure Borate Co7B24O42 (OH)2·2H2O — Formation of Edge‐Sharing BO4 Tetrahedra in a Hydrate Borate.
Authors: Neumair Stephanie C. , Kaindl Reinhard , Huppertz Hubert 
Published: March 2012

AbstractViolet, air‐ and water‐resistant crystals of the title compound are synthesized from a stoichiometric mixture of Co3O4 and H3BO3 (Walker‐type multianvil apparatus, 6 GPa, 880 °C, 5 min).
ChemInform Abstract: Revisiting the Properties of Delafossite CuCrO2: A Single Crystal Study.
Authors: Poienar Maria , Hardy Vincent , Kundys Bohdan , Singh Kiran , Maignan Antoine , Damay Francoise , Martin Christine 
Published: March 2012

AbstractPlate‐like single crystals of the title compound are prepared by thermal decomposition of K2Cr2O7 in the presence of CuO and B2O3 at 900 °C.
ChemInform Abstract: Synthesis and Characterization of Versatile MgO—ZrO2 Mixed Metal Oxide Nanoparticles and Their Applications.
Authors: Gawande Manoj B. , Branco Paula S. , Parghi Kalpesh , Shrikhande Janhavi J. , Pandey Rajesh Kumar , Ghumman C. A. A. , Bundaleski N. , Teodoro O. M. N. D. , Jayaram Radha V. 
Published: March 2012

AbstractNano‐MgO/ZrO2 is prepared and used as catalyst for cross‐aldol condensation, Cbz‐protection of amines, reduction of aromatic nitro compounds and the synthesis of 1,5‐benzodiazepines.
ChemInform Abstract: Nonconcerted Cycloaddition of 2H‐Azirines to Acylketenes: A Route to N‐Bridgehead Heterocycles.
Authors: Khlebnikov Alexander F. , Novikov Mikhail S. , Pakalnis Viktoriia V. , Yufit Dmitry S. 
Published: March 2012

AbstractTreatment of acylketenes with 2‐unsubstituted and 2‐monosubstituted 3‐arylazirines leads to bicyclic oxazines of type (VIII) and/or unusual bridged 2:1 adducts like (IV) and (IX) depending on steric effects.
ChemInform Abstract: Thiourea Dioxide Promoted Efficient Organocatalytic One‐Pot Synthesis of a Library of Novel Heterocyclic Compounds.
Authors: Verma Sanny , Kumar Subodh , Jain Suman L. , Sain Bir 
Published: March 2012

AbstractThiourea dioxide is applied as catalyst under solvent‐free conditions for the library synthesis of heterocyclic compounds such as the functionalized coumarins (III) and (V), the highly functionalized piperidines (VIII) and (IX), and the dipyrromethanes (XII).