bluuebunny/crossref_metadata_2025_split huggingface dataset:
Common Carotid End-Diastolic Velocity and Intima-Media Thickness Jointly Predict Ischemic Stroke in Taiwan
Authors: Chuang Shao-Yuan , Bai Chyi-Huey , Chen Jiunn-Rong , Yeh Wen-Ting , Chen Hsin-Jen , Chiu Hou-Chang , Shiu Ruei-Shiang , Pan Wen-Harn 
Published: March 2011

Background and Purpose—
In Asian populations, few studies investigated the association between stroke and common carotid artery intima-media thickness (IMT). Our previous case-control studies showed that low end-diastolic velocity (EDV) in common carotid artery, a potential hemodynamic marker of intracranial resistance, was associated with ischemic stroke. Therefore, we investigated the relationship between both EDV and IMT and incident ischemic stroke in an Asian population.

Methods—
Baseline data from 3175 adults (30 years or older) in the Cardiovascular Diseases Risk Factor Two-Township Study were linked to incidental ischemic stroke status derived from insurance claims and death certificate records. Hazard ratios for risk of ischemic stroke for high IMT and low EDV values measured in common carotid artery were calculated using Cox proportional hazard models.

Results—
With 9.85 years (median) of follow-up, 184 persons had ischemic stroke develop. Compared with the first tertile of IMT, hazard ratios were 2.03 (95% confidence intervals, 1.27–3.25) for the second tertile and 3.87 (95% confidence intervals, 2.36–5.69) for the third tertile. Hazard ratios of EDV were 5.31 (95% confidence intervals, 3.52–7.99; first tertile) and 1.94 (95% confidence intervals, 1.21–3.09; second tertile) compared with the third tertile. The individuals with high IMT and low EDV had >2-fold ischemic stroke risk compared to those with low IMT and high EDV (2.10; 95% confidence intervals, 1.35–3.26) after adjusting for age, sex, and traditional cardiovascular risk.

Conclusions—
Common carotid IMT and EDV jointly and independently predicted future ischemic stroke in this Taiwanese population. More prospective studies are required in various ethnic groups to understand the significance and implication of the current findings, particularly with respect to EDV.
Can Regional Climate Models Represent the Indian Monsoon?
Authors: Lucas-Picher Philippe , Christensen Jens H. , Saeed Fahad , Kumar Pankaj , Asharaf Shakeel , Ahrens Bodo , Wiltshire Andrew J. , Jacob Daniela , Hagemann Stefan 
Published: March 2011

AbstractThe ability of four regional climate models (RCMs) to represent the Indian monsoon was verified in a consistent framework for the period 1981–2000 using the 45-yr European Centre for Medium-Range Weather Forecasts (ECMWF) Re-Analysis (ERA-40) as lateral boundary forcing data. During the monsoon period, the RCMs are able to capture the spatial distribution of precipitation with a maximum over the central and west coast of India, but with important biases at the regional scale on the east coast of India in Bangladesh and Myanmar. Most models are too warm in the north of India compared to the observations. This has an impact on the simulated mean sea level pressure from the RCMs, being in general too low compared to ERA-40. Those biases perturb the land–sea temperature and pressure contrasts that drive the monsoon dynamics and, as a consequence, lead to an overestimation of wind speed, especially over the sea. The timing of the monsoon onset of the RCMs is in good agreement with the one obtained from observationally based gridded datasets, while the monsoon withdrawal is less well simulated. A Hovmöller diagram representation of the mean annual cycle of precipitation reveals that the meridional motion of the precipitation simulated by the RCMs is comparable to the one observed, but the precipitation amounts and the regional distribution differ substantially between the four RCMs. In summary, the spread at the regional scale between the RCMs indicates that important feedbacks and processes are poorly, or not, taken into account in the state-of-the-art regional climate models.
The Impact of Dropwindsonde Data from the THORPEX Pacific Area Regional Campaign and the NOAA Hurricane Field Program on Tropical Cyclone Forecasts in the Global Forecast System
Authors: Aberson Sim D. 
Published: March 2011

Four aircraft released dropwindsondes in and around tropical cyclones in the west Pacific during The Observing System Research and Predictability Experiment (THORPEX) Pacific Area Regional Campaign (T-PARC) in 2008 and the Dropwindsonde Observations for Typhoon Surveillance near the Taiwan Region (DOTSTAR); multiple aircraft concurrently participated in similar missions in the Atlantic. Previous studies have treated each region separately and have focused on the tropical cyclones whose environments were sampled. The large number of missions and tropical cyclones in both regions, and additional tropical cyclones in the east Pacific and Indian Oceans, allows for the global impact of these observations on tropical cyclone track forecasts to be studied. The study shows that there are unintended global consequences to local changes in initial conditions, in this case due to the assimilation of dropwindsonde data in tropical cyclone environments. These global impacts are mainly due to the spectral nature of the model system. These differences should be small and slightly positive, since improved local initial conditions should lead to small global forecast improvements. However, the impacts on tropical cyclones far removed from the data are shown to be as large and positive as those on the tropical cyclones specifically targeted for improved track forecasts. Causes of this unexpected result are hypothesized, potentially providing operational forecasters tools to identify when large remote impacts from surveillance missions might occur.
Presentation of a virtual power plant environment and its application with combined first-principle and data-driven models intended for the diagnostics of a power plant – Part 1
Authors: Barszcz Tomasz , Czop Piotr 
Published: March 2011

This work aims to present and discuss the architecture and application aspects of the Virtual Power Plant (VPP) environment, a tool created for the purpose of modeling, simulation, data management, and visualization of power plant systems. The VPP environment is based on a general-purpose simulation package that provides a framework for incorporating a broad variety of models, ranging from real-time models to detailed models that require off-line execution. The VPP, as a tool, opens up the possibility to develop, test, and validate the feasibility of new software and hardware components within simulated operational scenarios. The first part of the work presents the architecture of the VPP and briefly describes its main components. The implementation, including necessary simplifications, encapsulation, and integration of sub-models is discussed and illustrated. A feedwater heater model is the main contributor to the performance of the entire simulation model of a power unit. In the first part of this work, the development process of such a model is presented, including necessary simplifications for improving its performance and functionality.
Evaluating the ‘next generation’ of cell salvage - will it make a difference?
Authors: Yarham Gemma , Clements Ann , Oliver Martin , Morris Christopher , Cumberland Tom , Bryan Megan , Jekler Sasa , Johns Kathy , Mulholland John 
Published: March 2011

Introduction: Donor blood supplies are diminishing, becoming more costly and these transfusions lead to higher mortality in cardiac patients. The transfusion risks and the literature highlight the need for an alternative similar to cell salvage to be routinely considered. The Xtra is the first cell saver to be launched since 2001 and will undoubtedly initiate evolution towards the ‘next generation’ of cell savers. It is also the first to be launched in a new era where the demand for electronic perfusion data management (EPDM) has grown. Results: The user interface (UI) was easy to use. The increased data entry options improved the quality of the recordable data. The integrated data management system (DMS) was comprehensive. Data was easy to manage and enabled central data compilation, which reduces repeated data, the risk of inconsistent data inventory and provides the potential for research and analyses. The haematocrit of the processed blood is a key quality indicator for cell salvage. The comparison of the manufacturer’s integrated protocol, Popt, to our team’s own protocol showed that Popt delivered a higher haematocrit on its ‘1st bowl’ (59.1% compared to 57.3%) and its ‘total process’ end product haematocrit was 0.68% higher. The Popt cycle took an average of 330s, whereas our own settings completed in just over 300s. Conclusion: The Xtra is a device which will lead the evolution of ‘next generation’ cell saver technology. The user interface and data management system provide export options and the ability to record the level of data required for good EPDM. This is essential to ‘future proof’ cell salvage technology. The manufacturer’s integrated protocol achieved a higher end product haematocrit than our perfusion team’s best practice. The design of the Xtra is contemporary, but the DMS equips this cell saver for the new era that faces both Perfusion and Cardiac Surgery.
Hyperproliferation, cancer, and inflammation in mice expressing a Δ133p53-like isoform
Authors: Slatter Tania L. , Hung Noelyn , Campbell Hamish , Rubio Carina , Mehta Reena , Renshaw Prudence , Williams Gail , Wilson Michelle , Engelmann Afra , Jeffs Aaron , Royds Janice A. , Baird Margaret A. , Braithwaite Antony W. 
Published: March 2011

Abstract
The p53 protein is a pivotal tumor suppressor that is frequently mutated in many human cancers, although precisely how p53 prevents tumors is still unclear. To add to its complexity, several isoforms of human p53 have now been reported. The Δ133p53 isoform is generated from an alternative transcription initiation site in intron 4 of the p53 gene (Tp53) and lacks the N-terminus. Elevated levels of Δ133p53 have been observed in a variety of tumors. To explore the functions of Δ133p53, we created a mouse expressing an N-terminal deletion mutant of p53 (Δ122p53) that corresponds to Δ133p53. Δ122p53 mice show decreased survival and a different and more aggressive tumor spectrum compared with p53 null mice, implying that Δ122p53 is a dominant oncogene. Consistent with this, Δ122p53 also confers a marked proliferative advantage on cells and reduced apoptosis. In addition to tumor development, Δ122p53 mice show a profound proinflammatory phenotype having increased serum concentrations of interleukin-6 and other proinflammatory cytokines and lymphocyte aggregates in the lung and liver as well as other pathologies. Based on these observations, we propose that human Δ133p53 also functions to promote cell proliferation and inflammation, one or both of which contribute to tumor development.
Neonatal NK-cell repertoires are functionally, but not structurally, biased toward recognition of self HLA class I
Authors: Schönberg Kathrin , Fischer Johannes C. , Kögler Gesine , Uhrberg Markus 
Published: March 2011

Abstract
Human natural killer (NK)–cell repertoires are biased toward more frequent expression of inhibitory killer cell Ig-like receptor (KIR) receptors for self-human leukocyte antigen (HLA) class I. Moreover, only those NK cells that express cognate receptors for self are fully functional in terms of cytotoxicity and cytokine production. It is so far unknown whether functional education and structural adaptation to HLA class I are implemented during NK-cell development and whether both processes are mechanistically connected. Here we show that NK-cell repertoires in cord blood are not yet shaped toward increased clonal frequencies of KIR for self-HLA class I as determined for the 3 major KIR ligands C1, C2, and Bw4. Nonetheless, neonatal NK cells expressing cognate KIR exhibited enhanced effector function on the level of degranulation and cytokine production. The study suggests that functional education of cognate KIR by self-HLA class I precedes structural adaptation of KIR repertoires and that both processes are not directly linked to each other.
Antibiotic prescribing for discoloured sputum in acute cough/lower respiratory tract infection
Authors: Butler C.C. , Kelly M.J. , Hood K. , Schaberg T. , Melbye H. , Serra-Prat M. , Blasi F. , Little P. , Verheij T. , Mölstad S. , Godycki-Cwirko M. , Edwards P. , Almirall J. , Torres A. , Rautakorpi U-M. , Nuttall J. , Goossens H. , Coenen S. 
Published: March 2011

We investigated whether discoloured sputum and feeling unwell were associated with antibiotic prescription and benefit from antibiotic treatment for acute cough/lower respiratory tract infection (LTRI) in a prospective study of 3,402 adults in 13 countries.A two-level model investigated the association between producing discoloured sputum or feeling generally unwell and an antibiotic prescription. A three-level model investigated the association between an antibiotic prescription and symptom resolution.Patients producing discoloured sputum were prescribed antibiotics more frequently than those not producing sputum (OR 3.2, 95% CI 2.1–5.0), unlike those producing clear/white sputum (OR 0.95, 95% CI 0.61–1.48). Antibiotic prescription was not associated with a greater rate or magnitude of symptom score resolution (as measured by a 13-item questionnaire completed by patients each day) among those who: produced yellow (coefficient 0.00; p = 0.68) or green (coefficient -0.01; p = 0.11) sputum; reported any of three categories of feeling unwell; or produced discoloured sputum and felt generally unwell (coefficient -0.01; p = 0.19).Adults with acute cough/LRTI presenting in primary care settings with discoloured sputum were prescribed antibiotics more often compared to those not producing sputum. Sputum colour, alone or together with feeling generally unwell, was not associated with recovery or benefit from antibiotic treatment.
Association between overweight, obesity and self-perceived job insecurity in German employees
Authors: Muenster Eva , Rueger Heiko , Ochsmann Elke , Letzel Stephan , Toschke André M 
Published: March 2011

Abstract

Background
Recent studies have shown an association between job insecurity and morbidity as well as mortality, however until now, knowledge about a potential association between job insecurity and overweight or obesity has been lacking.

Methods
In order to identify a possible association between job insecurity and overweight or obesity, we analysed data from the German Socioeconomic Panel (GSOEP) 2004/2005, a longitudinal study of private households in Germany. In this representative cohort of the German adult population, living and working conditions were observed. Data on Body Mass Index (BMI) and self-perceived probability of job loss within the next 2 years were available for 10,747 adults either employed or attending training programs.

Results
We identified 5,216 (49%) individuals as being overweight (BMI > 25 kg/m2) and 1,358(13%) individuals as being obese (BMI > 30 kg/m2). A total of 5,941 (55%) participants reported having concerns regarding job insecurity. In the multivariate analysis - after adjustment for relevant confounders - a statistically significant association between obesity and job insecurity (100% probability for losing the job in the following two years) could be observed with an adjusted odds ratio of 2.55 (95% confidence interval: 1.09-5.96).

Conclusions
Because of these results, we were able to conclude that overweight and obese persons perceive job insecurity more often than their normal weight counterparts in Germany and that the concurrence of obesity and job insecurity might lead employees into a vicious cycle. Further research with an emphasis on the occupational setting might be necessary in order to establish useful preventive programmes at the workplace.
Case report of rapidly progressive proliferative verrucous leukoplakia and a proposal for aetiology in mainland China
Authors: Ge Lin , Wu Yun , Wu Lan-yan , Zhang Lin , Xie Bing , Zeng Xin , Lin Mei , Zhou Hong-mei 
Published: March 2011

Abstract
Proliferative verrucous leukoplakia (PVL) is a rare oral leukoplakia and has four features such as chronic proliferation, multiple occurrences, refractoriness to treatment and high rate of malignant transformation. As mentioned above, most PVL cases processed to malignancy over many years, sometimes 20 years. However, this report described a case of rapid progress, which had malignant transformation in a short period. Additionally, the aetiology of PVL was discussed and immunity was proposed as the possible cause.
Multiscale investigation of graphene layers on 6H-SiC(000-1)
Authors: Tiberj Antoine , Huntzinger Jean-Roch , Camassel Jean , Hiebel Fanny , Mahmood Ather , Mallet Pierre , Naud Cecile , Veuillen Jean-Yves 
Published: March 2011

AbstractIn this article, a multiscale investigation of few graphene layers grown on 6H-SiC(000-1) under ultrahigh vacuum (UHV) conditions is presented. At 100-μm scale, the authors show that the UHV growth yields few layer graphene (FLG) with an average thickness given by Auger spectroscopy between 1 and 2 graphene planes. At the same scale, electron diffraction reveals a significant rotational disorder between the first graphene layer and the SiC surface, although well-defined preferred orientations exist. This is confirmed at the nanometer scale by scanning tunneling microscopy (STM). Finally, STM (at the nm scale) and Raman spectroscopy (at the μm scale) show that the FLG stacking is turbostratic, and that the domain size of the crystallites ranges from 10 to 100 nm. The most striking result is that the FLGs experience a strong compressive stress that is seldom observed for graphene grown on the C face of SiC substrates.
Synthesis, structure, and opto-electronic properties of organic-based nanoscale heterojunctions
Authors: Rezek Bohuslav , Čermák Jan , Kromka Alexander , Ledinský Martin , Hubík Pavel , Mareš Jiří J , Purkrt Adam , Cimrová Vĕra , Fejfar Antonín , Kočka Jan 
Published: March 2011

AbstractEnormous research effort has been put into optimizing organic-based opto-electronic systems for efficient generation of free charge carriers. This optimization is mainly due to typically high dissociation energy (0.1-1 eV) and short diffusion length (10 nm) of excitons in organic materials. Inherently, interplay of microscopic structural, chemical, and opto-electronic properties plays crucial role. We show that employing and combining advanced scanning probe techniques can provide us significant insight into the correlation of these properties. By adjusting parameters of contact- and tapping-mode atomic force microscopy (AFM), we perform morphologic and mechanical characterizations (nanoshaving) of organic layers, measure their electrical conductivity by current-sensing AFM, and deduce work functions and surface photovoltage (SPV) effects by Kelvin force microscopy using high spatial resolution. These data are further correlated with local material composition detected using micro-Raman spectroscopy and with other electronic transport data. We demonstrate benefits of this multi-dimensional characterizations on (i) bulk heterojunction of fully organic composite films, indicating differences in blend quality and component segregation leading to local shunts of photovoltaic cell, and (ii) thin-film heterojunction of polypyrrole (PPy) electropolymerized on hydrogen-terminated diamond, indicating covalent bonding and transfer of charge carriers from PPy to diamond.
Recent pattern of Co-infection amongst HIV seropositive individuals in tertiary care hospital, kolkata
Authors: Saha Kallol , Firdaus Rushna , Santra Poonam , Pal Jyotirmoy , Roy Arnab , Bhattacharya Mihir K , Chakrabarti Sekhar , Sadhukhan Provash C 
Published: March 2011

Abstract

Background
Opportunistic Infections (OIs) and co-infections are the major cause of deaths amongst HIV infected individuals and this mostly depends upon the risk factors, type of exposure and geographic region. The commonest types of infections reported are tuberculosis, chronic diarrhoea, oral candidiasis, herpes simplex virus-2, cytomegalovirus, hepatitis B virus and hepatitis C virus. Due to the scarcity of OIs data available from this region, we had designed a study to determine the frequency of different OIs amongst HIV seropositive patients.

Methods
Analysis of the different spectrum of OIs/Co-infections were carried out with 204 HIV sero-positive patients (142 males and 62 females) who visited the HIV/AIDS Apex Clinic in a tertiary care hospital from March 2006 to March 2009. The CD4+ count was estimated using FACS Calibur, the routine smear test, serology, nested RT-PCR and DNA sequencing were carried out to determine the different OIs.

Results
In this study, HIV seropositive patients were mostly from middle age group (31-40 yrs) with CD4+ counts in majority of symptomatic AIDS patients below 200 cells/mm3. The common co-infections/opportunistic infections were OC (53.43%), CD (47.05%), HSV-2 (36.76%), TB (35.29%), CMV (26.96%), HBV (15.19%) and HCV (7.35%). Dual infections, like HSV-2 & CMV (15.38%), HSV-2 & TB (14.61%), HSV-2 & oral candidiasis (24.61%) and CMV & oral candidiasis (14.61%) were significant in follow-up patients. Triple infections were also common e.g., TB, CD, OC infection occurring frequently in about 14.21% of the study population. Multiple infections like OC, TB, CD amongst the viral co-infected patients with HSV-2, HCV, CMV and HBV are also reported in this study. The genotyping analysis of the HCV co-infected HIV individuals shows that two belonged to HCV genotype 1 and 8 belonged to genotype 3.

Conclusions
A wide spectrum of OIs were observed amongst HIV-infected patients in the HIV/AIDS Apex Clinic. Oral candidiasis, CD, CMV and HSV-2, were the common OIs in those patients. This study aims to provide a clearer picture regarding infections occurring amongst HIV seropositive individuals so that the scientific findings could be translated into sustainable prevention programmes and improved public health policies.

Trial registration
None