bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac remodeling in patients with heart failure with mildly reduced ejection fraction and metabolic disorders: association with biomarkers and autonomic nervous system parameters
Authors: Lyasnikova E. A. , Gareeva A. I. , Muslimova V. K. , Zhabina E. S. , Kozlova S. N. , Sitnikova M. Yu. , Shlyakhto E. V. 
Published: May 2024

Aim. The high prevalence of obesity in a cohort of patients with heart failure and mildly reduced ejection fraction (HFmrEF) determines the relevance of clarifying the role of biomarkers and autonomic imbalance in myocardial remodeling, taking into account metabolic risk factors.Material and methods. We examined 19 men with postinfarction cardiosclerosis and class II HFmrEF (median age 62 years), overweight/class I-II obesity, type 2 diabetes in 53/47%, 48% of cases, respectively, who received therapy. The biomarker panel included N-terminal pro-brain natriuretic peptide (NT-proBNP), galectin-3, pro-collagen I C-terminal propeptide (PICP), N-terminal propeptide of procollagen type III (PIIINP), C-terminal telopeptide of type I collagen, matrix metalloproteinase-9 (MMP-9), tissue inhibitor of matrix proteinase-1 (TIMP-1), leptin and adiponectin. Heart rate variability (HRV) and turbulence were obtained using 24-hour Holter monitoring. We assessed the time and frequency domains of HRV (24 h) and 5 min recordings of wakefulness at rest, calculated TO (turbulence onset) and TS (turbulence slope).Results. Significant positive associations of leptin and TIMP-1 levels with left ventricular hypertrophy markers were confirmed. Positive correlations of peak e' with following HRV indicators were revealed: SDNN (r=0,68; p=0,02) and RMSSD (r=0,69; p=0,003). Lower TS values were associated with higher index parameters of left ventricular mass (p<0,05 for all). Associations of biomarkers with autonomic nervous system (ANS) were observed: MMP-9 with RMSSD (r=0,54) and pNN50 (r=0,51); TIMP-1 with TO (r=0,46); PICP/PIIINP ratio with HFn (5 min) (r=-0,49); NT-proBNP/adiponectin ratio with SDNN (r=-0,49); leptin level with TS (r=-0,54) (p<0,05 for all).Conclusion. In patients with HFmrEF of ischemic origin and additional metabolic risks, serum biomarkers of fibrosis, adipokines, and ANS parameters are associated mainly with markers of increased left ventricular filling pressure. The study results predetermine the further search for potential risk-stratification markers of unfavorable myocardial remodeling and prognosis in large samples of patients with metabolic deviations and HF with EF >40% against the background of modern drug therapy.
Particularities of the course and treatment of non-ST elevation acute myocardial infarction: data from the REGION-IM registry
Authors: Boytsov S. A. , Shakhnovich R. M. , Tereshchenko S. N. , Erlikh A. D. , Pevzner D. V. , Gulyan R. G. , Rytova Yu. K. , Khegya D. V. , Khafizov A. A. , Kuzmicheva T. V. , Potapova A. N. , Gaskova E. Yu. , Medvedeva N. A. , Gorozhankina T. A. , Stavtseva M. A. , Romakh I. V. 
Published: May 2024

Aim. To characterize patients with acute non-ST elevation myocardial infarction (NSTEMI) hospitalized in Russian hospitals, study their anamnestic, demographic and clinical characteristics, treatment features and hospital outcomes, as well as compare data from previous Russian and foreign registries of acute coronary syndrome.Material and methods. Russian Registry of Acute Myocardial Infarction (REGION-IM) is a multicenter prospective observational study. The case report form contains demographic and anamnestic data, as well as the following information about the present MI: timing of symptom onset, first contact with medical personnel and admission to the hospital; data from coronary angiography (CAG) and percutaneous coronary intervention (PCI), therapy, hospitalization outcomes.Results. In total, for the period from November 1, 2020 to June 30, 2023, the study included 3253 patients with STEMI from 73 hospitals (30 vascular surgery departments, 17 of which are equipped with angiographic system, and 43 regional vascular surgery centers) from 45 constituent entities of the Russian Federation. There were 55% of high-risk patients. CAG was performed in 83,73% of patients. In 81%, CAG was performed ≤24 hours from hospitalization. PCI was performed in 62% of patients with NSTEMI. Median onset-to-balloon time was 27 hours [10;77]. The median door-to-balloon time was 5 hours [1;20]. Inhospital mortality was 3%. In the group with CAG, compared with the group without CAG, inhospital mortality was lower (2% and 6%, respectively; p<0,05). In patients with a higher risk according to the GRACE, CRUSADE and ARC-HBR scales, CAG was performed less frequently.Conclusion. In patients with NSTEMI in Russian regions, there is a high frequency of CAG and PCI, including in the early stages. Inhospital mortality is low, especially in the invasive treatment group, and corresponds to data from international registries. In severely ill patients, revascularization is performed less frequently than in low-risk patients. There is room for increasing the prescription rate of modern effective anticoagulants and antiplatelet agents. In general, the quality of treatment for NSTEMI patients has improved in recent years.
Young cardiologists: innovative approaches and development prospects. Activities of the working group "Young Cardiologists" of the Russian Society of Cardiology
Authors: Lyapina I. N. , Kruchinova S. V. , Skorodumova E. G. , Kozik V. A. 
Published: May 2024

Рабочая группа Российского кардиологического общества (РКО) "Молодые кардиологи" по праву занимает первое место среди всех структур общества по активности и включенности членов группы в совместную работу.
Chemoreactomic analysis of the antioxidant properties of vitamin B12 derivatives
Authors: Torshin I. Yu. , Gromova O. A. , Maiorova L. A. 
Published: May 2024

Background. Synthetic derivatives of vitamin B12 exhibit various physical, chemical and pharmacological properties. The development of methods for predicting the properties of these molecules based on their chemical structure is important for the targeted organic synthesis of corrins with the desired properties and range of applications in pharmacology.Objective: chemoreactomic assessment of the antioxidant effects of vitamin B12 and its derivatives: aquacobalamin, diaquacobinamide, aquacyano-forms of heptaethanolamine-, heptaethylenediamine-, heptamethyl- and heptabutylcobyrinates.Material and methods. The study was conducted using the method of chemoreactomic analysis, implemented within the framework of the algebraic theory of recognition and topological data analysis and based on the theory of isomorphism of labeled graphs and modern methods for predicting numerical target variables. To carry out chemoinformatic chemoreactome analysis, a special problem-oriented theory was developed within the boundaries of the combinatorial theory of solvability and the antioxidant properties of vitamin B12 derivatives were assessed (140 activities in total).Results. Significant differences were found in the properties of the studied substances in relation to oxidative stress. In test systems based on the oxidant 1,1-diphenyl-2-picrylhydrazyl, at different exposure times to molecules (15–60 min) in different concentrations (10–125 μM, 50–3000 μg/ml), aquacobalamin exhibited the most pronounced antioxidant properties at lower concentrations (up to 100 µM). At higher concentrations of substances (125 μM), the antioxidant activity of other vitamin B12 derivatives was higher. All studied molecules had a moderate antimicronutrient effect (total score of about 3.0; for most synthetic drugs, this score is higher than 3.6). Aquacobalamin was characterized by the least pronounced antimicronutrient effect (total score less than 0.8), which indicates an almost complete absence of antivitamin and antimineral action, corresponding to an average increase in the risk of a particular micronutrient excretion by no more than 5%.Conclusion. All the studied compounds exert antioxidant properties to one degree or another. Regardless of the choice of simulated test systems for assessing oxidative stress, aquacobalamin demonstrated antioxidant effects to the greatest extent and practically did not stimulate the loss of other micronutrients.
Effect of Coffea canephora Bean Extract on Lead Acetate-Induced Rats
Authors: Moch. Ilham Riza Fahlefi  , Maya Nurwartanti Yunita  , Indaka Rachmach Choirunnisa  , Farodina Azka Zhafira  , Fania Aulia Rahma  
Published: May 2024

Lead (Pb) is a non-essential heavy metal that is toxic and has no known uses. Most cases of poisoning in livestock are caused by lead poisoning. This study aims to determine the effect of Coffea canephora bean extract as an antioxidant on the heart histopathological features of white rats (Rattus norvegicus) induced by lead acetate. This study used 25 male Wistar rats aged between eight and ten weeks and weighing between 200 and 250 grams. The rats were divided into five treatment groups, namely negative control (C-), positive control (C+), treatment one (T1), treatment two (T2), and treatment three (T3). The results suggested that the administration of 200 mg/kg BW, 400 mg/kg BW, or 800 mg/kg BW of Coffea canephora bean extract was not effective in improving the heart histopathological features, including cell degeneration, hemorrhage, and necrosis, of rats induced with lead acetate at a dose of 2 mg/kg BW.
Chemosensitizing effect of pentoxifylline in sensitive and multidrug-resistant non-small cell lung cancer cells
Authors: Matos Beatriz S. , Peixoto da Silva Sara , Vasconcelos M. Helena , Xavier Cristina P. R. 
Published: May 2024

Aim: Multidrug resistance (MDR) is frequent in non-small cell lung cancer (NSCLC) patients, which can be due to its fibrotic stroma. This work explores the combination of pentoxifylline, an anti-fibrotic and chitinase 3-like-1 (CHI3L1) inhibitor drug, with conventional chemotherapy to improve NSCLC treatment.
Methods: The effect of pentoxifylline in the expression levels of P-glycoprotein (P-gp), CHI3L1 and its main downstream proteins, as well as on cell death, cell cycle profile, and P-gp activity was studied in two pairs of sensitive and MDR counterpart NSCLC cell lines (NCI-H460/NCI-H460/R and A549/A549-CDR2). Association studies between CHI3L1 gene expression and NSCLC patients’ survival were performed using The Cancer Genome Atlas (TCGA) analysis. The sensitizing effect of pentoxifylline to different drug regimens was evaluated in both sensitive and MDR NSCLC cell lines. The cytotoxicity of the drug combinations was assessed in MCF10A non-tumorigenic cells.
Results: Pentoxifylline slightly decreased the expression levels of CHI3L1, β-catenin and signal transducer and activator of transcription 3 (STAT3), and caused a significant increase in the G1 phase of the cell cycle in both pairs of NSCLC cell lines. A significant increase in the % of cell death was observed in the sensitive NCI-H460 cell line. TCGA analysis revealed that high levels of CHI3L1 are associated with low overall survival (OS) in NSCLC patients treated with vinorelbine. Moreover, pentoxifylline sensitized both pairs of sensitive and MDR NSCLC cell lines to the different drug regimens, without causing significant toxicity to non-tumorigenic cells.
Conclusion: This study suggests the possibility of combining pentoxifylline with chemotherapy to increase NSCLC therapeutic response, even in cases of MDR.
Analysis Of The Value For Money In Measuring The Financial Performance Of Pamekasan District Government For Fiscal Year 2017-2021
Authors: Asti Talitha Rahima Widya Paramesti  , Diah Armeliza  , Hera Khairunnisa  
Published: May 2024

Abstract

This study to determine the financial performance Government of Pamekasan Regency by using the Value for Money concept to measure the level of economical, eficiency and ef ectiveness of the regional finance of the Pamekasan Regency for the 2017- 2021 fisical year. The research used secondary data from the Pamekasan Regency Regional Revenue and Financial Management agency website. This research was conducted by taking data for 5 years. This research is a descriptive study with the object being studied is the data of the Financial Report of Pamekasan Regency Local Government which is the Government’s Regional Revenue and Expenditure Budget Realization Report (RAPBD). The data collection method used is documentation. The data analysis technique used is quantitative descriptive analysis. Based on the results of research on local financial performance Government of Pamekasan regency using the Value for Money concept based on 3 main ratio such as economy, efficiency, effectiveness.
The results of the research from an economic level are that in the 2017 to 2021 budget year, the Pamekasan Regency Government succeeded in achieving an economic performance level of between 80.4% and 88% with the "economic" criteria. The average economic level for 5 years is 83.58%, which means it is in the economic category. In terms of efficiency, the research results show that the efficiency level of the Pamekasan Regency Government's financial performance in 2017-2018 was efficient and in 2019-2021 it was inefficient. The average efficiency level for 5 years is 100.003%, which means it is in the inefficient category. The results of calculating the level of effectiveness of the Pamekasan Regency Government's financial performance in 2017-2018 were in the "effective" category and in 2019-2021 described "ineffective" in revenue management with an average effectiveness level of 100.7%.
Based on the results of these studies, the Value for Money concept is very good to be applied to the Government of Pamekasan Regency because it can comprehensive performance overview.
Keyword: Value for Money; Regional Financial Performance; economy, efficiency, effectiveness.
The Influence of Digital Leadership on Organizational Performance in Jakarta
Authors: Nurshinta  , Vira Deyana Cindy  , Osly Usman  
Published: May 2024

Digital technology's transformative influence in business is undeniable, reshaping strategies and operations. Embracing this change goes beyond tech adoption it requires aligning culture, structure, and people with the evolving landscape. Digital leadership is crucial in navigating this realm, impacting job motivation, innovation, and overall performance. However, the relationship between digital leadership, employee performance, and digital culture is complex and context-dependent. The study aims to investigate the impact of digital leadership on organizational performance, with digital culture, digital technology, and digital marketing as intervening variables concerning sustainability and organizational performance in Jakarta. It uses a quantitative approach to analyze the numerical relationship between the variables. Utilizing a Purposive Sampling design, the Partial Least Square (PLS) approach will be employed for study analysis, with assistance from the SMARTPLS 4.0 application. Digital culture, marketing, and technology are all has significant influence by digital leadership. Higher digital leadership positively correlates with increased digital culture, marketing, and technology, while lower digital leadership negatively affects these aspects. Digital culture significantly influences organizational performance. Meanwhile, digital marketing shows a positive influence on performance but lacks significance. Digital technology positively and significantly affects organizational performance. Prioritize the enhancement of digital leadership to advance digital culture, marketing strategies, and technological implementation within organizations. Examine how digital culture contributes to organizational performance, emphasizing a culture fostering innovation, adaptability, and collaboration.
Detection of the invasive tree species Hovenia dulcis Thumb. (Rhamnaceae) in an urban remnant of Atlantic Forest through Remote Sensing techniques combined with RGB images obtained by an unmanned aerial vehicle (UAV)
Authors: Wiesel Patrik Gustavo , Schroeder Marcos Henrique , Bruno Deprá , Salgueiro Bianca Junkherr , Barreto Betina Mariela , de Santana Eduardo Rodrigo Ramos , Köhler Andreas , Lobo Eduardo Alcayaga 
Published: May 2024

Abstract

The invasive Hovenia dulcis is considered the main invasive species in the Atlantic Forest, capable of altering environmental conditions on a local scale and producing profound changes in the composition of the plant community. Combining images obtained by drones and satellite imagery can make forest monitoring more efficient. It enables a more efficient and targeted response to contain the spread of invasive species. Additionally, phytosociological studies can contribute to understanding the structure of the native tree community and the impacts generated by biological invasion. This research aimed to use CBERS4-A satellite images with a high-resolution suitable for applying land use and land cover classification methods. Automatic supervised object-directed classification was performed through the Dzetsaka Classification Tool, using the Gaussian Mixture Model method. 150 hectares of georeferenced orthomosaics obtained through drones was using to confirm the identification of the invader. The entire area was traversed to determine the tree community, and 72 random sample plots were established, each with a fixed area of 100 m². Calculated indices of Shannon Index (H’) = 3.65 and Uniformity (J’) = 78% demonstrate that the plant community has a high diversity of species. H. dulcis had the highest number of sampled individuals (146), being the species with the highest Relative Density (9.14) within the community, and the second-highest in Relative Frequency (5.10%), Coverage Importance Value (8.85%), and Importance Value Index (7.60%). The methodology employed for invader identification through satellite and drone images allowed for rapid and precise data collection, covering an area of 86.44 hectares.
Protocol for the development and piloting of a cluster randomised controlled trial for stress prevention, management, and coping mechanism among police officers in Nigeria
Authors: Oluwasanu Mojisola , Oladeji Bibilola , Oluwatobi Hussain , Titiloye Musibau , Adefolarin Adeyinka , Osondu Unogu , Okafor Patrick , Ajayi Olayinka , Uvere Ezinne , Ajuwon Ademola J. 
Published: May 2024

Abstract

Background Policing is a stressful occupation. Police officers are exposed to stressors that are inherent in the organization and operations of the law enforcement institution. Similar to their counterparts around the world, many Nigeria police officers are exposed to high levels of stress, making them vulnerable to stress-related mental health conditions and other non-communicable diseases. Despite these risks and their consequences to the health and safety of police officers and the larger society, interventions are currently not available to address this challenge in Nigeria. The current study is designed to address this knowledge gap. This pilot study aims to assess the burden of stress from a national sample of police officers and test the feasibility of an intervention for stress prevention, management, and coping mechanisms among police officers in Nigeria.Methods This is a three-phase study (1) a needs assessment and situational analysis using a mixed methods approach to determine the prevalence of stress and mental health burden among 1200 police officers in four randomly selected states in four geo-political zones of the country (2) the development of a peer-led intervention for stress prevention, management, and coping mechanism which will be tested using a cluster randomized trial among 200 police officers and (3) the preliminary evaluation of the intervention based on knowledge about stress management and mental disorders and psychological distress and reduction in stress levels. These measures will be obtained at baseline, immediate, and six months post-intervention. Feasibility will be determined based on enrollment rate, attendance and completion of the group sessions. Linear regression models taking into account clustering effects will be used to estimate between-group differences in outcome measures.Discussion Findings from the study will inform policy review and the development of a pragmatic intervention on stress prevention and management among police officers. This will enhance the policing role of officers, thus contributing to the safety of the communities they serve.Trial registration PACTR Registry: PACTR202310474721238. Registered on 6 October, 2023, https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=25663
A process parameters decision approach considering spindle vibration in helical surface milling for minimizing energy consumption and surface roughness value
Authors: Zhang Weifeng , Sun Xingwei , Yang Heran , Liu Yin , Dong Zhixu , zhao Hongxun , Mu Shibo , Chen Jiahao 
Published: May 2024

Abstract

The concavity and convexity of complex helical surface makes it the characteristic of variable feed speed and load processing, which leads to long machining time, high energy consumption power for material removal. The concavity and convexity of complex surfaces exacerbate spindle vibration during milling, resulting in poor machining quality and high energy consumption. For the high quality and low energy consumption machining of helical surface, this paper proposes a method of optimising the energy consumption of process parameters of CNC milling machine for helical groove considering spindle vibration. Firstly, based on the orthogonal test data, the influence of process parameters on spindle vibration, etc. is analysed, and the empirical model of spindle vibration is established through process parameters. Aiming at the prediction error caused by the multicollinearity problem of the energy consumption mechanism model due to the regression fitting method, it is proposed to construct an energy consumption error compensation model based on the data-driven by improved stochastic configuration network algorithm through the use of process parameters, and to combine the mechanism model with the error compensation model, so as to improve the prediction accuracy of the machining energy consumption. Finally, the multi-objective optimisation problem of the helical surface milling is solved by the improved non-dominated sorting algorithm, which is verified by actual machining comparison with expeeience process parameters. The results show that the optimised machining energy consumption is reduced by 17.52% and the surface roughness value is reduced by 6.07%, which proves that the method proposed in this paper can provide certain theoretical support for the machine tool industry to achieve green manufacturing.
Paradox in climate change mitigation: behavioural attitudes among residents of Sri Lankan households
Authors: Kalubowila Kasuni , Arambepola Carukshi 
Published: May 2024

Abstract

Three focus group discussions (FGD) were conducted among residents already practising climate change mitigative activities, low-income urban communities and rural residents to identify the behavioural attitudes on climate mitigation in households in the district of Colombo. Eight adult residents aged 18 years or above were purposively selected for each discussion. The principal investigator conducted all discussions with the assistance of a note-taker, using a semi-structured FGD guide. The thematic analysis was carried out to identify the beahvioural attitudes. Of the 24 participants, 14 were men and 10 were women, while 10 were < 40 years of age. Views on the existance of climate change were based on recent increase in temperature and natural disasters. Behavioural attitudes on climate change mitigation were generated under several themes: causes for climate change, perceptions on vulnerability to effects of climate change, negative attitudes towards climate mitigation, new technologies used for climate mitigation, carbon tax, green test and views on government responsibilities towards climate mitigation. The findings showed that behavioural attitudes are more driven by poor scientific knowledge, poverty and cultural beliefs which should be addressed by mitigative actions.