bluuebunny/crossref_metadata_2025_split huggingface dataset:
Semantic middleware for e‐Science knowledge spaces
Authors: Futrelle Joe , Gaynor Jeff , Plutchak Joel , Myers James D. , McGrath Robert E. , Bajcsy Peter , Kastner Jason , Kotwani Kailash , Lee Jong Sung , Marini Luigi , Kooper Rob , McLaren Terry , Liu Yong 
Published: March 2011

SUMMARYThe Tupelo semantic content management middleware implements Knowledge Spaces that enable scientists to integrate information into a comprehensive research record as they work with existing tools and domain‐specific applications. Knowledge Spaces combine approaches that have demonstrated success in automating parts of this integration activity, including content management systems for domain‐neutral management of data, workflow technologies for management of computation and analysis, and semantic web technologies for extensible, portable, citable management of descriptive information and other metadata. Tupelo's ‘Context’ facility and its associated semantic operations both allow existing data representations and tools to be plugged in, and also provide a semantic ‘glue’ of important associative relationships that span the research record, such as provenance, social networks, and annotation. Tupelo has enabled the recent work creating e‐Science cyberenvironments to serve distributed, active scientific communities, allowing researchers to develop, coordinate and share datasets, documents, and computational models, while preserving process documentation and other contextual information needed to produce an integrated research record suitable for distribution and archiving. Copyright © 2011 John Wiley & Sons, Ltd.
Power‐aware provisioning of virtual machines for real‐time Cloud services
Authors: Kim Kyong Hoon , Beloglazov Anton , Buyya Rajkumar 
Published: March 2011

AbstractReducing power consumption has been an essential requirement for Cloud resource providers not only to decrease operating costs, but also to improve the system reliability. As Cloud computing becomes emergent for theAnything as a Service(XaaS) paradigm, modern real‐time services also become available through Cloud computing. In this work, we investigate power‐aware provisioning of virtual machines for real‐time services. Our approach is (i) to model a real‐time service as a real‐time virtual machine request; and (ii) to provision virtual machines in Cloud data centers using dynamic voltage frequency scaling schemes. We propose several schemes to reduce power consumption by hard real‐time services and power‐aware profitable provisioning of soft real‐time services. Copyright © 2011 John Wiley & Sons, Ltd.
Cooperative multitasking for GPU‐accelerated grid systems
Authors: Ino Fumihiko , Ogita Akihiro , Oita Kentaro , Hagihara Kenichi 
Published: March 2011

SUMMARYThis paper presents a cooperative multitasking method for concurrent execution of scientific and graphics applications on the graphics processing unit (GPU). Our method is designed to accelerate compute unified device architecture‐based applications using idle GPU cycles in the office. To prevent significant slow‐down of graphics applications, the method divides scientific tasks into smaller pieces, which are then sequentially executed at the appropriate intervals. The method also has flexibility in finding the best tradeoff point between scientific applications and graphics applications. Experimental results show that the proposed method is useful to control the frame rate of the graphics application and the throughput of the scientific application. For example, biological sequence alignment can be processed at approximately 30% of the dedicated throughput while achieving interactive rendering at 58 frames per second. We also show that matrix multiplication can be efficiently processed at 60% of the dedicated throughput during word processing and web browsing. Copyright © 2011 John Wiley & Sons, Ltd.
Monitoring CD4 in whole blood with an opto‐fluidic detector based on spatially modulated fluorescence emission
Authors: Kiesel Peter , Beck Markus , Johnson Noble 
Published: March 2011

AbstractWe describe a new optical detection technique, termed “spatially modulated fluorescence emission,” that delivers high signal‐to‐noise discrimination without precision optics to enable a flow cytometer that can combine high performance, robustness, compactness, low cost, and ease of use. The detection technique is demonstrated with measurements of absolute CD4+ and percentage CD4 counts in human blood. Benchmarking against a commonly used commercial instrument for this test yields excellent agreement for both absolute CD4 and percentage CD4. © 2011 International Society for Advancement of Cytometry
Evolution of transthoracic fine needle aspiration and core needle biopsy practice: A comparison of two time periods, 1996–1998 and 2003–2005
Authors: Minot Douglas M. , Jaben Elizabeth , Aubry Marie‐Christine , Voss Jesse S. , Vine Roanna L. , Lee Peter U. , Carlson Stephanie K. , Clayton Amy C. 
Published: March 2011

AbstractTo examine the performance of our large pulmonary transthoracic fine needle aspiration/core biopsy (FNA/CB) practice over time, we performed a retrospective analysis of data from 333 consecutive procedures performed in 1996–1998 and 568 consecutive procedures performed in 2003–2005. Fluoroscopic guidance was performed more frequently in the earlier cohort, while a larger majority of procedures in the later cohort were by computed tomography (CT‐guidance). A follow‐up histologic diagnosis of cancer or clinical evidence of disease was considered the gold‐standard. FNA/CB procedures during the later time period were performed on smaller lesions overall (3.60 cm versus 2.97 cm; P = 0.003) and malignant lesions also tended to be smaller (3.87 cm versus 3.14 cm; P = 0.006). Minimal improvements in sensitivity (94% versus 91%), specificity (99% versus 95%), diagnostic accuracy (95% versus 92%), negative predictive value (NPV) (80% versus 74%), and positive predictive value (PPV) (100% versus 99%) were noted during 2003–2005 when compared with 1996–1998 in all lesions. Larger improvements in sensitivity (94% versus 73%), diagnostic accuracy (95% versus 79%), and NPV (79% versus 50%) were identified in very small lesions (<1 cm) in the later patient cohort in comparison to the earlier patient cohort, as well as a significant decrease in total procedure complications. CT‐guided transthoracic FNA/CB continues to be a very effective tool in our practice assessing lung lesions and performance has improved considerably at our institution for very small lesions. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.
Fascin as an identifier of metastatic urothelial carcinoma: A retrospective study of fine‐needle aspiration cell blocks and histologic tissue microarrays
Authors: Vogt Adam P. , Cohen Cynthia , Siddiqui Momin T. 
Published: March 2011

AbstractFascin, a marker of invasiveness in urothelial carcinoma, has not been correlated with metastatic disease. To enhance diagnostic accuracy and correctly identify primary site for appropriate patient management, fascin may be a useful marker in metastatic urothelial carcinoma. In this study, we evaluated twenty five cases with adequate cell block material for immunohistochemistry (IHC) staining in patients with either concurrent or previously resected urothelial carcinoma between 2005 and 2010. Fascin, thrombomodulin, uroplakin, cytokeratin 7, and cytokeratin 20 IHC were performed on paraffin‐embedded cell block serial sections. Fascin was over‐expressed in the majority (23/25, 92%) of metastatic urothelial carcinomas. We found concordant results in 22 of 25 (88%) cases for fascin and thrombomodulin IHC staining. Either fascin and/or thrombomodulin demonstrated positive staining in 25 of 25 (100%) cases. Histologic tissue microarrays of 72 genitourinary (GU) carcinomas of the kidney and prostate were stained with fascin to reveal all cases to be negative in the cells of interest. In comparing fascin with the traditional markers of urothelial carcinoma, fascin expression is of greater frequency and intensity than thrombomodulin. The combination of fascin and/or thrombomodulin identified all 25 (100%) cases of urothelial carcinoma. Fascin IHC staining is equivalent in frequency and intensity to cytokeratin 7. Fascin is an advantageous diagnostic complement, to thrombomodulin and/or cytokeratin 7, in the setting of metastatic urothelial carcinoma, and is highly specific and sensitive relative to GU malignancies. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.
Cytopathologic features and differential diagnostic considerations of primary lymphoepithelioma‐like carcinoma of the lung
Authors: Hayashi Toshitetsu , Haba Reiji , Tanizawa Junko , Katsuki Naomi , Kadota Kyuichi , Miyai Yumi , Bando Kenji , Shibuya Shinsuke , Nakano Masayuki , Kushida Yoshio 
Published: March 2011

AbstractPrimary lymphoepithelioma‐like carcinoma (LELC) of the lung is an extremely rare disease that occurs more commonly in Asians, and is composed of undifferentiated carcinoma with prominent lymphoid stroma. LELC is reported to be closely associated with Epstein‐Barr virus (EBV) infection. A case is presented here in which bronchial brushing smears in a 70‐year‐old man, revealed large clusters of neoplastic cells with scant cytoplasm. The nuclei were large, hyperchromatic, of irregular contour and with prominent nucleoli. Also identified were prominent intratumoral lymphoid infiltration and brisk mitotic figures. We detected EBV‐coded small RNA in situ hybridization in smears. A cytologic diagnosis of a LELC was suggested. Further evaluation and immunohistochemical studies were conducted on formalin‐fixed, paraffin‐embeddedmaterial. Cords or nests of large neoplastic cells with enlarged nuclei and prominent nucleoli with marked lymphoid infiltration and lymphoid stroma were identified on H&E sections. Immunohistochemically, the tumor cells showed diffuse and strong membranous staining for CK(AE1/AE3), CK5/6, CK34βE12, Napsin A and Bcl‐2 but were negative for CK7, CK14, CK20, EMA, TTF‐1, chromogranin A, synaptophysin and CD56. The proliferative index with MIB‐1 was around 60%, and the p53 positive cells around 20%. The diagnosis of primary LELC of the lung was confirmed based on cytopathologic, histopathologic, immunohistochemical and EBER results, and a detailed systemic examination to exclude possible extrapulmonary (nasopharyngeal) origin. We report the cytopathological features of LELC of the lung and demonstrate here for the first time the positivity of the EBER with RNA‐ISH method in smears with emphasis on differential diagnostic considerations. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.
Sex and experience influence behavioral responses of adult rats to potentiated and nonpotentiated ultrasonic vocalizations of pups
Authors: Rohitsingh Shelly‐Ann , Smith Jonathan A. , Shair Harry N. 
Published: March 2011

AbstractResponsiveness of adult rodent caretakers to infant rodents is necessary for their survival and proper development. Both olfactory and auditory cues are known to influence adult behavior toward the young. In the present study, we found that adults respond differentially to a recording of potentiated vs. non‐potentiated ultrasound vocalizations of a 12‐day‐old rat pup, either in the presence or absence of olfactory cues. The combination of olfactory and potentiated ultrasonic vocalization produced the greatest effect. Adult behavior was also affected by the adults' sex and parental experience in an interaction. Parental experience of females made them more responsive to the type of ultrasonic vocalization; males were little affected. Female experience, of course, includes the hormonal changes due to pregnancy and lactational state. The results are consistent with a communicatory function for isolation‐induced ultrasonic vocalization. © 2011 Wiley Periodicals, Inc. Dev Psychobiol 53:677–684, 2011.
Changes in object‐oriented arm movements that precede the transition to goal‐directed reaching in infancy
Authors: Lee Mei‐Hua , Ranganathan Rajiv , Newell Karl M. 
Published: March 2011

AbstractThe emergence of prehensile skills in infancy is one of the central issues in motor development. The objective of this longitudinal study was to quantitatively describe the changes in the object‐oriented arm movements that precede the transition to goal‐directed reaching movements in infancy. Arm kinematics in 10 full‐term infants were recorded biweekly from the age of 10 to 28 weeks while objects were presented for prehension. The kinematics were analyzed across three progressive phases of object‐oriented arm movements (early, before, and after onset of reaching movements). As infant age increased through the stage of object‐oriented movements, the distinguishing feature was that there was a decrease in movement jerk (when normalized to a dimensionless quantity), which reflects the increasing ability to adaptively modulate arm movements. This change in the dynamic characteristics of the object‐oriented arm movements precedes the onset of goal‐directed reaching movements and is hypothesised to reflect a critical variable in the infant developmental process of learning to reach in prehension. © 2011 Wiley Periodicals, Inc. Dev Psychobiol 53:685–693, 2011.
Individual behavioral phenotypes: An integrative meta‐theoretical framework. Why “behavioral syndromes” are not analogs of “personality”
Authors: Uher Jana 
Published: March 2011

AbstractAnimal researchers are increasingly interested in individual differences in behavior. Their interpretation as meaningful differences in behavioral strategies stable over time and across contexts, adaptive, heritable, and acted upon by natural selection has triggered new theoretical developments. However, the analytical approaches used to explore behavioral data still address population‐level phenomena, and statistical methods suitable to analyze individual behavior are rarely applied. I discuss fundamental investigative principles and analytical approaches to explore whether, in what ways, and under which conditions individual behavioral differences are actually meaningful. I elaborate the meta‐theoretical ideas underlying common theoretical concepts and integrate them into an overarching meta‐theoretical and methodological framework. This unravels commonalities and differences, and shows that assumptions of analogy to concepts of human personality are not always warranted and that some theoretical developments may be based on methodological artifacts. Yet, my results also highlight possible directions for new theoretical developments in animal behavior research. © 2011 Wiley Periodicals, Inc. Dev Psychobiol 53:521–548, 2011.
Adrenocortical responses to strangers in preschoolers: Relations with parenting, temperament, and psychopathology
Authors: Hastings Paul D. , Ruttle Paula L. , Serbin Lisa A. , Mills Rosemary S.L. , Stack Dale M. , Schwartzman Alex E. 
Published: March 2011

AbstractPrevious research has provided inconsistent evidence for the relations between young children's hypothalamic–pituitary–adrenal (HPA) functioning and their temperament, parenting, and adjustment. Building biopsychosocial models of adjustment, we examined how temperamental inhibition and maternal punishment contributed to preschoolers' adrenocortical activity while interacting with adult strangers. We also examined whether HPA functioning moderated relations between dispositional and familial factors and children's internalizing and externalizing problems. A total of 402 preschool‐aged children from three independent samples with parallel and overlapping measures were studied. Salivary cortisol levels were measured twice while interacting with adult strangers during testing protocols. Mothers reported on temperamental inhibition, maternal punishment and children's problems. Maternal punishment predicted higher cortisol levels 20 and 65 min after meeting adult strangers. Prolonged cortisol elevation was associated with having fewer externalizing problems. Boys who experienced more maternal punishment and had higher cortisol 20 min after meeting strangers manifested more externalizing problems. Girls who were more inhibited and had prolonged cortisol elevations had more internalizing problems. In accord with biopsychosocial models of psychopathology, HPA functioning in preschoolers was sensitive to variations in socialization experiences, and moderated children's risk for emotional and behavioral problems. © 2011 Wiley Periodicals, Inc. Dev Psychobiol 53:694–710, 2011.
BDNF control of adult SVZ neurogenesis
Authors: Bath Kevin G. , Akins Michael R. , Lee Francis S. 
Published: March 2011

AbstractThe sensory processing of odorants is a dynamic process that requires plasticity at multiple levels. In the olfactory bulb (OB), inhibitory interneurons undergo lifelong replacement through a process known as adult neurogenesis. These newly born cells are incorporated in a learning‐dependent fashion, a process which has led some to suggest this as a primary mechanism through which the OB retains a high degree of plasticity throughout life. A continued focus of researchers in this field has been to understand the molecular mechanisms controlling adult subventricular zone (SVZ) neurogenesis and the innate functional role of these cells. Brain‐derived neurotrophic factor (BDNF) has been identified as a strong candidate molecule regulating adult OB neurogenesis. We review what is known regarding the functional role of newly born cells, highlight the role of BDNF in this process, and describe preliminary findings from our lab implicating BDNF in the process of selecting of newly born cells for survival. © 2011 Wiley Periodicals,Inc. Dev Psychobiol 54: 578–589, 2012..
Long‐term visual recognition of familiar persons, peers, and places by young monkeys (Macaca fuscata)
Authors: Murai Chizuko , Tanaka Masayuki , Tomonaga Masaki , Sakagami Masamichi 
Published: March 2011

AbstractFive‐year‐old Japanese monkeys were tested on long‐term visual recognition memory. The objects used were those that they had encountered daily during their first 2 years of life as to‐be‐remembered stimuli: persons, peers, and places. After a 3‐year delay, we conducted a recognition test using the preferential looking paradigm where the monkeys were presented with pictures of these familiar stimuli in combination with those of novel stimuli. The monkeys looked relatively longer at pictures of familiar stimuli than at those of novel stimuli, while participants in the control group, who had never seen the stimuli in question, showed no discriminative preference. The monkeys thus recognized the familiar stimuli through the pictures, suggesting retention of visual information on real objects encountered in their lives even after a 3‐year delay. Our present findings confirmed long‐term visual recognition in monkeys, which might be essential to ecologically and socially significant behaviors such as individual identification. © 2011 Wiley Periodicals, Inc. Dev Psychobiol 53:732–737, 2011.
Diabetes and bone health: the relationship between diabetes and osteoporosis‐associated fractures
Authors: Kurra Salila , Siris Ethel 
Published: March 2011

AbstractIt is well established that osteoporosis and diabetes are prevalent diseases with significant associated morbidity and mortality. The relationship between diabetes and bone disease is less well defined but recent data seem to suggest that diabetes and the complications associated with it can be detrimental to bone health. Furthermore, it appears that thiazolidinediones, medications used in the treatment of diabetes, can also cause bone loss and increase the risk of fracture. This article will review the relationship between diabetes and bone health. Copyright © 2011 John Wiley & Sons, Ltd.
Renal involvement and left ventricular hypertrophy are novel risk factors for morbidity and mortality in diabetes mellitus
Authors: Boner Geoffrey 
Published: March 2011

AbstractDiabetes mellitus and its complications are major causes of morbidity and mortality. Traditionally hypertension and poor diabetic control have been considered to be major risk factors for the development of cardiac involvement. This review will examine two novel risk factors, namely renal involvement and left ventricular hypertrophy.Renal involvement is manifested by increased excretion of protein in the urine and/or decreasing renal function. Several large studies have shown that both these factors are significant risk factors for cardiac involvement and increased mortality both in diabetic and non‐diabetic subjects. There is strong evidence to suggest an association between renal and cardiac involvement.Cardiac hypertrophy is an important risk factor for the development of cardiac involvement. It is generally assumed that ventricular hypertrophy is a result of hypertension. However, it has been shown to be associated with metabolic disorders such as central obesity, diabetes mellitus and hypercholesterolemia, even in the absence of hypertension. The prevalence of ventricular hypertrophy is increased in patients with diabetes mellitus, especially in the presence of renal involvement. Diabetic patients with renal involvement and cardiac hypertrophy have also been shown to have an increased risk for developing cardiac complications and having an increased mortality rate.Thus these two risk factors are important in the prognosis of the diabetic patient. Follow‐up of the diabetic patient should include careful examination for the presence of proteinuria, reduced renal function and left ventricular hypertrophy in the hope that treatment of these factors may reduce morbidity and mortality. Copyright © 2011 John Wiley & Sons, Ltd.
Efficient inducible Cre‐mediated recombination in Tcf21cell lineages in the heart and kidney
Authors: Acharya Asha , Baek Seung Tae , Banfi Serena , Eskiocak Banu , Tallquist Michelle D. 
Published: March 2011

AbstractTcf21 is a Class II bHLH family member with essential roles in the formation of the lungs, kidneys, gonads, spleen, and heart. Here, we report the utility of a mouse line with targeted insertion of a tamoxifen‐inducible Cre recombinase, MerCreMer at the Tcf21 locus. This mouse line will permit the inducible expression of Cre recombinase in Tcf21‐expressing cells. Using ROSA26 reporter mice, we show that Cre recombinase is specifically and robustly activated in multiple Tcf21‐expressing tissues during embryonic and postnatal development. The expression profile in the kidney is particularly dynamic with the ability to cause recombination in mesangial cells at one time of induction and podocytes at another time. These features make the Tcf21‐driven inducible Cre line (Tcf21iCre) a valuable genetic tool for spatiotemporal gene function analysis and lineage tracing of cells in the heart, kidney, cranial muscle, and gonads. genesis 49:870–877, 2011. © 2011 Wiley‐Periodicals, Inc.
Radical Coordination Chemistry and Its Relevance to Metal‐Mediated Radical Polymerization (Eur. J. Inorg. Chem. 10/2011)
Authors: Poli Rinaldo 
Published: March 2011

AbstractThe cover picture shows two different and interplaying processes involving a metal complex and organic radicals, which play a key role in the controlled radical polymerization of vinyl acetate by what has been termed “Organometallic Mediated Radical Polymerization” (OMRP). Bis(acetylacetonato)cobalt(II), Co(acac)2, reversibly adds the growing radical chain (symbolized by “M + R�”) to form a dormant metal‐capped (acac)2Co–PVAc chain (“M–R”), which contains a thermally fragile metal–carbon bond. The latter, however, in addition to the reversible radical chain dissociation, can also undergo an associative radical‐chain exchange through a transition state symbolized as “R···M···R”. This is just one example of how one‐electron processes involving metal complexes and radicals play a fundamental role in radical polymerization. It is the topic of the Microreview by R. Poli on p. 1513 ff, covering the coordination chemistry of organic radicals and its relevance to metal‐mediated radical polymerization. The background image represents a random conformation of a poly(vinyl acetate) chain segment.