bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Gingival Crevicular Fluid Levels of Interleukin‐11 and Interleukin‐17 in Patients With Aggressive Periodontitis
Authors: Ay Zuhal Yetkin , Yılmaz Gülin , Özdem Muhsin , Koçak Havva , Sütçü Recep , Uskun Ersin , Tonguç Mine Öztürk , Kırzıoğlu Fatma Yeşim 
Published: January 2012

Background: The balance (ratio) of anti‐inflammatory and proinflammatory cytokines is thought to play an important role in the pathogenesis of chronic periodontitis. Moreover, the imbalance of anti‐inflammatory/proinflammatory cytokines may modulate disease progression in aggressive periodontitis (AgP). This study aims to investigate the levels of interleukin (IL)‐11 and IL‐17 and their ratio in gingival crevicular fluid (GCF) in patients with AgP.Methods: This study included 20 patients with generalized AgP (GAgP) and 18 healthy controls (HC). For each patient, the values of clinical parameters, such as gingival index, plaque index, probing depth, and clinical attachment level, were recorded. Levels of IL‐11 and IL‐17 in GCF samples were evaluated using enzyme‐linked immunosorbent assay. The values of clinical parameters, cytokine levels, and the ratios of cytokines were evaluated.Results: The values of all the clinical parameters were significantly higher in the GAgP group than in the HC group (P <0.001). The total amount and concentration of IL‐11 and the concentration of the IL‐17 and IL‐11/IL‐17 ratio were significantly lower in the GAgP group than in the HC group (P <0.001). The total amount of IL‐17 was not significantly different between the groups (P = 0.317)Conclusions: The IL‐11/IL‐17 ratio was decreased in the GAgP group because of the decreased IL‐11 levels. The IL‐11/IL‐17 axis and the link between IL‐17 and neutrophil function disorders in AgP should be investigated to clarify the role of the IL‐11/IL‐17 axis and its balance and imbalance in the pathogenesis of AgP.
Periodontal Status and Metabolic Syndrome in Middle‐Aged Japanese
Authors: Fukui Nao , Shimazaki Yoshihiro , Shinagawa Takashi , Yamashita Yoshihisa 
Published: January 2012

Background: Metabolic syndrome (MetS) increases the risk of various lifestyle‐related diseases. Although some studies have reported a significant relationship between periodontal status and MetS, little information exists about the nature of the relationship between periodontal health status and MetS.Methods: Comprehensive health examinations of 6,421 Japanese individuals (aged 34 to 77 years) were performed. Five components (obesity, high blood pressure, low high‐density lipoprotein cholesterol, hypertriglyceridemia, and high plasma glucose) of MetS were evaluated, and individuals with ≥3 positive components were defined as having MetS. The periodontal parameters were periodontal probing depth (PD) and clinical attachment level (CAL), and each parameter was divided into three categories (none/mild: ≤3 mm; moderate: 4 to 5 mm; and severe: ≥6 mm).Results: When PD and CAL were analyzed separately in multivariate models, both parameters were significantly associated with MetS. In a multivariate logistic regression analysis using a combination of PD and CAL as an independent variable, individuals with severe PD and severe CAL or with moderate PD and moderate CAL had significantly higher odds ratios for MetS, but severe CAL without severe PD was not significantly associated with MetS.Conclusion: The results of this study suggest that periodontal status, particularly in individuals suspected to have untreated periodontal infection indicated by ≥4 mm PD, is significantly associated with MetS.
Dynamics of episodic transient correlations in currency exchange rate returns and their predictability
Authors: Žukovič Milan 
Published: January 2012

AbstractWe study the dynamics of the linear and non-linear serial dependencies in financial time series in a rolling window framework. In particular, we focus on the detection of episodes of statistically significant two- and three-point correlations in the returns of several leading currency exchange rates that could offer some potential for their predictability. We employ a rolling window approach in order to capture the correlation dynamics for different window lengths and analyze the distributions of periods with statistically significant correlations. We find that for sufficiently large window lengths these distributions fit well to power-law behavior. We also measure the predictability itself by a hit rate, i.e. the rate of consistency between the signs of the actual returns and their predictions, obtained from a simple correlation-based predictor. It is found that during these relatively brief periods the returns are predictable to a certain degree and the predictability depends on the selection of the window length.
Normalized gait parameters in NDT-Bobath post-stroke gait rehabilitation
Authors: Mikołajewska Emilia 
Published: January 2012

AbstractThe aim of the research was to evaluate the results of NDT-Bobath method in gait re-education of adult patients after ischemic stroke using normalized parameters of gait. The investigation group consisted of 60 patients, all sufferers of an ischemic stroke, and participated in a rehabilitation program: 10 sessions of NDT-Bobath therapy through 2 weeks (ten days of the therapy). Normalized parameters of gait were calculated based on anthropometric measures of patients and their gait parameters (gait velocity, cadence and stride length) measured in every patient on admission (before the therapy) and after the last session of the therapy to assess rehabilitation effects. Results among patients involved in the research were as follows:
in normalized gait velocity: recovery in 42 cases (70 %), relapse in 10 cases (16,67 %), no measurable changes in 8 cases (13.33 %)in normalized cadence: recovery in 39 cases (65 %), relapse in 16 cases (26.67 %), no measurable changes in 5 cases (8.33 %)in normalized stride length: recovery in 50 cases (83.33 %), relapse in 4 cases (6.67 %), no measurable changes in 6 cases (10 %).
Observed statistically significant and favourable changes in health status of patients, described by normalized gait parameters, confirm effectiveness of the NDT-Bobath method.
Vaccination in children with cancer: a debate
Authors: Battista Andrea , Ruggiero Antonio , Coccia Paola , Arena Roberta , Attinà Giorgio , Riccardi Riccardo 
Published: January 2012

AbstractChildren with malignancy present an important alteration of the immune system functionality caused by the illness itself and by the therapy they undergo. Therefore, they are at high risk of contracting vaccine-preventable diseases and of developing important complications. Vaccinations represent valid devices against these infections but this condition involves two main problems: are vaccines safe in these patients? Are vaccines effective in these patients? The aim of this review is to discuss the principles of vaccination management in children with cancer.
Safety and efficacy of exercise testing with atropine in patients with recent uncomplicated ST elevation acute myocardial infarction
Authors: Sarullo Filippo , Americo Luigi , Milia Salvatore , Brusca Ignazio , Faraone Natale , Franco Antonino , Giambanco Salvatore , Franco Marco , Panno Vittorio , Paterna Salvatore , Pasquale Pietro 
Published: January 2012

Abstract
Early Badenian ostracod assemblage of the Židlochovice stratotype(Carpathian Foredeep, Czech Republic)
Authors: Seko Michal , Pipík Radovan , Doláková Nela 
Published: January 2012

AbstractFifty-two ostracod taxa were identified from two sediment cores collected from the early Badenian Židlochovice stratotype. Ostracod assemblages were analyzed with a focus on taxonomy, paleoecology, distribution of taxa along the sediment cores, quantification of valve/carapace ratios, and species richness by Simpson’s Reciprocal Index. The changes in ostracod assemblages identified in these cores reflect a shallowing of the marine water-depth from circalittoral/epibathyal to shallow infralittoral, and an increase in the sedimentation rate upwards through time. A comparison of all Badenian ostracod assemblages in the Carpathian Foredeep indicates a high proportion of deep-water ostracod species in Židlochovice and its surroundings, suggesting that the deepest part of the Carpathian Foredeep was probably situated in this part of the Czech Republic.
Cutaneous leishmaniasis: a case report
Authors: Kayastha BMM , Shrestha P , Shrestha R , Jahan R 
Published: January 2012

Cutaneous Leishmaniasis (CL) is a vector-borne protozoal infection of the skin. It is endemic in the tropics and neotropics. Several species of Leishmania cause this disease in the Old World. It is manifested as chronic nodular to ulcerative lesions of the skin, which last for many months and may be disfiguring. Despite its increasing worldwide incidence, it is infrequently reported from Nepal. We are reporting a case of CL in a man who acquired the disease while working in Saudi Arabia and who was successfully treated with Sodium Stibogluconate injections. DOI: http://dx.doi.org/10.3126/njdvl.v8i1.5715 Nepal Journal of Dermatology, Venereology & Leprology 8(1) 2009 27-30
Transmission eigenvalue distributions in highly conductive molecular junctions
Authors: Bergfield Justin P , Barr Joshua D , Stafford Charles A 
Published: January 2012

Background:The transport through a quantum-scale device may be uniquely characterized by its transmission eigenvalues τn. Recently, highly conductive single-molecule junctions (SMJ) with multiple transport channels (i.e., several τn> 0) have been formed from benzene molecules between Pt electrodes. Transport through these multichannel SMJs is a probe of both the bonding properties at the lead–molecule interface and of the molecular symmetry.Results:We use a many-body theory that properly describes the complementary wave–particle nature of the electron to investigate transport in an ensemble of Pt–benzene–Pt junctions. We utilize an effective-field theory of interacting π-electrons to accurately model the electrostatic influence of the leads, and we develop an ab initio tunneling model to describe the details of the lead–molecule bonding over an ensemble of junction geometries. We also develop a simple decomposition of transmission eigenchannels into molecular resonances based on the isolated resonance approximation, which helps to illustrate the workings of our many-body theory, and facilitates unambiguous interpretation of transmission spectra.Conclusion:We confirm that Pt–benzene–Pt junctions have two dominant transmission channels, with only a small contribution from a third channel with τn<< 1. In addition, we demonstrate that the isolated resonance approximation is extremely accurate and determine that transport occurs predominantly via the HOMO orbital in Pt–benzene–Pt junctions. Finally, we show that the transport occurs in a lead–molecule coupling regime where the charge carriers are both particle-like and wave-like simultaneously, requiring a many-body description.
Agreement with Guidelines from a Large Database for Management of Systemic Sclerosis: Results from the Canadian Scleroderma Research Group
Authors: POPE JANET , HARDING SARAH , KHIMDAS SARIT , BONNER ASHLEY ,   the Canadian Scleroderma Research Group, BARON MURRAY 
Published: January 2012

Objective.We determined congruence with published guidelines from the European League Against Rheumatism (EULAR)/EULAR Scleroderma Trials and Research group, for systemic sclerosis (SSc) investigations and treatment practices within the Canadian Scleroderma Research Group (CSRG).Methods.Investigations and medication use for SSc complications were obtained from records of patients with SSc in the CSRG to determine adherence to guidelines for patients enrolled before and after the guidelines were published.Results.The CSRG database of 1253 patients had 992 patients with SSc enrolled before publication of the guidelines and 261 after. For pulmonary arterial hypertension (PAH) treatment, there were no differences in use before and after the guidelines, yet annual echocardiograms for PAH screening were done in 95% of patients enrolled before the guidelines and in only 86% of those enrolled after (p <0.0001), and fewer followup echocardiograms were done 1 year later in the latter group (88% vs 59%). No differences were found for the frequency of PAH-specific treatment; 60% had ever used calcium channel blockers for Raynaud’s phenomenon, with no differences in the groups before and after the guidelines. But the use of phosphodiesterase type 5 inhibitors (which does not have guidelines) was increased in the after-guidelines group. Proton pump inhibitors were used in > 80% with gastroesophageal reflux disease before and after the guidelines. One-quarter with gastrointestinal symptoms were taking prokinetic drugs. For those with past SSc renal crisis, use of angiotensin-converting enzyme inhibitors was not different before and after the guidelines. For early diffuse SSc < 2 years, ever-use of methotrexate was similar (one-quarter of each group); and for symptomatic interstitial lung disease, 19% had ever used cyclophosphamide before the guidelines and 9% after (p = nonsignificant). CSRG practices were generally comparable to recently published guidelines; however, use of iloprost and bosentan was low for digital ulcers because these drugs are not approved for use in Canada.Conclusion.There did not seem to be an increase in adherence to recommendations once the guidelines were published. For many guidelines, 25% to 40% of patients who would qualify received the recommended treatment.
Remission in Early Rheumatoid Arthritis: Predicting Treatment Response
Authors: MA MARGARET H.Y. , IBRAHIM FOWZIA , WALKER DAVID , HASSELL ANDREW , CHOY ERNEST H. , KIELY PATRICK D.W. , WILLIAMS RICHARD , WALSH DAVID A. , YOUNG ADAM , SCOTT DAVID L. 
Published: January 2012

Objective.Optimizing therapeutic strategies to induce remission requires an understanding of the initial features predicting remission. Currently no suitable model exists. We aim to develop a remission score using predictors of remission in early rheumatoid arthritis (RA).Methods.We used a dataset from a UK randomized controlled trial that evaluated intensive treatment with conventional combination therapy, to develop a predictive model for 24-month remission. We studied 378 patients in the trial who received 24 months’ treatment. Our model was validated using data from a UK observational cohort (Early RA Network, ERAN). A group of 194 patients was followed for 24 months. Remission was defined as 28-joint Disease Activity Score < 2.6. Logistic regression models were used to estimate the associations between remission and potential baseline predictors.Results.Multivariate logistic regression analyses showed age, sex, and tender joint count (TJC) were independently associated with 24-month remission. The multivariate remission score developed using the trial data correctly classified 80% of patients. These findings were replicated using ERAN. The remission score has high specificity (98%) but low sensitivity (13%). Combining data from the trial and ERAN, we also developed a simplified remission score that showed that younger men with a TJC of 5 or lower were most likely to achieve 24-month remission. Remission was least likely in older women with high TJC. Rheumatoid factor, rheumatoid nodules, and radiographic damage did not predict remission.Conclusion.Remission can be predicted using a score based on age, sex, and TJC. The score is relevant in clinical trial and routine practice settings.
Predictors of Early Minimal Disease Activity in Patients with Psoriatic Arthritis Treated with Tumor Necrosis Factor-α Blockers
Authors: IERVOLINO SALVATORE , DI MINNO MATTEO NICOLA DARIO , PELUSO ROSARIO , LOFRANO MARIANA , RUSSOLILLO ANNA , DI MINNO GIOVANNI , SCARPA RAFFAELE 
Published: January 2012

Objective.To identify predictors of early minimal disease activity in patients with psoriatic arthritis (PsA) receiving tumor necrosis factor-α (TNF-α) antagonists.Methods.In total 146 consecutive patients with PsA eligible for anti-TNF-α therapy were enrolled. At baseline (T0) information about age, sex, PsA subset, disease duration, comorbidities, and treatments was collected. All subjects were tested for metabolic syndrome (MetS) and/or liver steatosis. A clinical and laboratory evaluation was performed at T0 and at 3 months (T3). Changes in all these variables were compared in subjects achieving minimal disease activity (MDA) and those who did not.Results.Among 146 PsA subjects, 10 discontinued therapy before 3-month followup because of adverse events; thus 136 concluded the study. All clinical outcome measures changed significantly from T0 to T3. Erythrocyte sedimentation rate showed a significant reduction (p < 0.001). C-reactive protein (CRP), serum cholesterol, and triglycerides showed no significant variation (p > 0.05). The prevalence of MetS and liver steatosis showed no significant differences between subjects achieving MDA and those who did not (p = 0.347 and 0.053, respectively). Patients achieving MDA at T3 were younger than those not achieving MDA (p = 0.001). A lower baseline tender joint count (p = 0.001), swollen joint count (p = 0.013), Bath Ankylosing Spondylitis Disease Activity Index (p = 0.021), and Ritchie index (p = 0.006) were found in subjects achieving MDA. Age (OR 0.896, p = 0.003) and Bath Ankylosing Spondylitis Functional Index (BASFI) (OR 0.479, p = 0.007) inversely predicted, whereas CRP (OR 1.78, p = 0.018) directly predicted, achievement of MDA at T3.Conclusion.In patients with PsA, age, CRP, and BASFI at the beginning of treatment were found to be reliable predictors of MDA after 3 months of TNF-α blocker therapy.
The Influence of Individual Joint Impairment on Functional Disability in Rheumatoid Arthritis Using a Large Observational Database of Japanese Patients
Authors: SHIDARA KUMI , INOUE EISUKE , HOSHI DAISUKE , TANAKA EIICHI , SETO YOHEI , NAKAJIMA AYAKO , MOMOHARA SHIGEKI , TANIGUCHI ATSUO , YAMANAKA HISASHI 
Published: January 2012

Objective.To clarify the influence of individual joint impairment on functional capacity through a retrospective study with a 3-year interval, using a large cohort of Japanese patients with rheumatoid arthritis (RA).Methods.Subjects included 3457 patients with RA who participated in a large observational cohort study in both April 2004 and April 2007; 43 joints were assessed and classified into 10 joint areas. Impairment of each joint area was scored based on the presence of swelling or tenderness: score 0 (no swelling or tenderness in either joint), score 1 (swelling or tenderness in a unilateral joint), and score 2 (swelling or tenderness in bilateral joints). Score change was defined as the difference between scores from 2004 and 2007. The Japanese validated version of the Health Assessment Questionnaire is the J-HAQ; ΔJ-HAQ score was determined by subtracting J-HAQ score in 2007 from that in 2004. The relationship between score change and ΔJ-HAQ score, and the effect of joint impairment on ΔJ-HAQ score were assessed.Results.Major joint areas that contributed to ΔJ-HAQ score included the wrist (31%), shoulder (21%), knee (13%), and ankle (10%). The shoulder, wrist, knee, and ankle in the worsening group were associated with a J-HAQ score increase of 0.13 to 0.18 compared to the improvement group.Conclusion.Our study demonstrated that impairment of the shoulder, wrist, knee, and ankle significantly affects functional capacity in patients with RA. Care of these joints is suggested to be especially important for better functional outcomes.
Le temps du passage. Temps psychique, temps du rite
Authors: Berruyer-Lamoine Bénédicte 
Published: January 2012

La temporalité psychique, à l’image du travail du deuil, a son propre rythme et sa logique interne. Pour autant, en s’étayant sur une temporalité proposée par la culture à travers les rites de passage et de deuil, les processus individuels de séparation et de deuil sont sécurisés et bordés, et l’individu n’est pas dans la solitude d’un chemin inconnu. Dans le travail psychanalytique individuel, le cadre peut proposer aussi un « bordage » temporel, soutenant le rythme psychique interne propre à chaque sujet.
Long-Term Arterial Adaptation to High Blood Flow in the Feeding Artery of Vascular Access for Hemodialysis
Authors: Tuka Vladimir , Malik Jan , Chytilova Eva , Kudlicka Jaroslav , Slavikova Marcela , Wijnen Edwin , Tordoir Jan HM , van Hooland Simon 
Published: January 2012

Purpose Arteries continuously respond to changing tissue demands and to hemodynamic conditions by altering their diameter and wall structure. The relatively slow dilatation of the feeding artery of vascular accesses continues at least two years after access creation with a continuous decrease in wall shear rate (WSR), which however, remains highly supra-physiological. The aim of this study was to test the hypothesis that after a longer time period the WSR returns to its baseline value. Methods In a cross-sectional study patients with arteriovenous fistulae were classified into four groups according to the access vintage (from new access to accesses older than six years). The WSR, cross-sectional area, and mean circumferential wall stress were measured and compared between groups. Results WSR decreased from group 1 (fistula < ninety days old) to group 4 (fistulae > six years old) with a concomitant increase in internal diameter. Patients with the oldest access had normal WSR values (compared to the contralateral brachial artery) and the largest internal diameter of the feeding artery. In diabetic patients the absolute values of WSR were higher and internal diameter was lower compared to nondiabetic patients. Conclusions Brachial artery WSR is normal in accesses older than six years with an increased internal diameter and wall cross-sectional area as compared to “younger” accesses. This suggests a process of vascular remodeling with an increase in vascular wall mass and normalization of WSR to physiologic values at the price of increased mean cross-sectional wall stress.
Polycyclic aromatic hydrocarbons (PAH) [Air Monitoring Methods, 2003b]
Authors: Meyer zu Reckendorf R. 
Published: January 2012

Abstract

Published in the series
Analyses of Hazardous Substances in Air
, Vol. 8 (2003)

The article contains sections titled:

General principles

Equipment, chemicals and solutions

Equipment

Chemicals

Solutions

Sample collection and preparation

Operating conditions

Operating conditions for gas chromatography

Operating conditions for mass spectrometry

Analytical determination

Calibration

Calibration of the gas sampler

Calibration of the personal air sampling device

Calibration of the GC/MS system

Calculation of the analytical result

Reliability of the method

Comments

Precision

Recovery

Quantification limit

Shelf‐life

Blank values

Analysis of the reference material SRM 1597

Comparison with BGI 505‐25 and PAH Method No. 2

Discussion of the method
Dieselmotoremissionen [Air Monitoring Methods in German language, 2006a]
Authors: Bauer H.‐D. , Dahmann D. , Fricke H.‐H. , Hebisch R. , Lehmann E. , Rentel K.‐H. 
Published: January 2012

AbstractVeröffentlicht in der ReiheAnalytische Methoden zur Prüfung gesundheitsschädlicher Arbeitsstoffe: Luftanalysen, 15. Lieferung, Ausgabe 2006Der Artikel enthält folgende Kapitel:Grundlage des VerfahrensGeräte, Chemikalien und LösungenGeräteChemikalien und LösungenProbenahme und ProbenaufbereitungVorbereitung der FilterProbenahmeProbenaufbereitungArbeitsbedingungenAnalytische BestimmungBestimmung des BlindwertesBestimmung des organisch gebundenen KohlenstoffsBestimmung des elementaren KohlenstoffsBestimmung des GesamtkohlenstoffsBerechnung des AnalysenergebnissesBeurteilung des VerfahrensPräzisionWiederfindungsrateNachweis‐ und BestimmungsgrenzeStöreinflüsseErgebnisse von VergleichsmessungenDiskussion