bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Selective Synthesis of C3 Symmetric Functionalized Sumanenes.
Authors: Higashibayashi Shuhei , Nasir Baig R. B. , Morita Yuki , Sakurai Hidehiro 
Published: May 2012

AbstractA protocol for the selective preparation of C3 symmetric triformylsumanene (VII), a versatile intermediate for various substituted sumanenes, is reported.
ChemInform Abstract: Devinylation of N‐Vinylpyrroles Using Mercury(II) Acetate.
Authors: Schmidt E. Yu. , Vasil'tsov A. M. , Zorina N. V. , Ivanov A. V. , Mikhaleva A. I. , Trofimov B. A. 
Published: May 2012

AbstractA known devinylation method is revised according to the assumed mechanism.
ChemInform Abstract: An Easy Approach for the Synthesis of N‐Substituted Isoindolin‐1‐ones.
Authors: Ordonez Mario , Tibhe Gaurao D. , Zamudio‐Medina Angel , Viveros‐Ceballos Jose Luis 
Published: May 2012

AbstractA three‐component reaction of o‐formylbenzoic acid, primary amines and dimethyl phosphite constitutes an efficient synthesis of isoindolinone phosphonates, which readily undergo dephosphorylation with LiAlH4.
ChemInform Abstract: Heterocyclization of trans‐1,2,3‐Triphenylcyclopropane Using Nitrous Acid.
Authors: Gazzaeva R. A. , Fedotov A. N. , Mochalov S. S. 
Published: May 2012

AbstractThe reaction of trans‐1,2,3‐triphenylcyclopropane (I) with one equivalent of nitrous acid provides access to the expected isoxazoline (II).
ChemInform Abstract: Catalytic [2 + 2] and [3 + 2] Cycloaddition Reactions of Allenoates with Cyclic Ketimines.
Authors: Chen Xiang‐Yu , Lin Ruo‐Chen , Ye Song 
Published: May 2012

AbstractThe Lewis base‐catalyzed cycloadditions of allenoates (II) and cyclic ketimines (I) are described.
ChemInform Abstract: Glycerol‐Mediated Synthesis of 5‐Substituted 1H‐Tetrazole under Catalyst‐Free Conditions.
Authors: Nandre Kamalakar P. , Salunke Jagdish K. , Nandre Jitendra P. , Patil Vijay S. , Borse Amul U. , Bhosale Sidhanath V. 
Published: May 2012

AbstractThe cycloaddition of aromatic and benzylic nitriles with sodium azide is conveniently achieved in glycerol to give the tetrazoles in good yields.
ChemInform Abstract: Generation of 11‐Fluoro‐11H‐indeno[1,2‐c]quinolines via a Palladium‐Catalyzed Three‐Component Reaction of 2‐Alkynylbromobenzenes, 2‐Alkynylanilines, and N‐Fluorobenzenesulfonimide.
Authors: Pan Xiaolin , Luo Yong , Liu Gang , Pu Shouzhi , Wu Jie 
Published: May 2012

AbstractThe reaction works with high chemoselectivity and diversity can be easily introduced.
ChemInform Abstract: An Environmentally Benign and Solvent‐Free Synthesis of 3‐Aryl[1,2,4]triazolo[4,3‐a]pyridines and 1‐Aryl‐5‐methyl[1,2,4]triazolo[4,3‐a]quinolines Using Phenyliodine Bis(trifluoroacetate) or Iodobenzene Diacetate.
Authors: Kumar P. 
Published: May 2012

AbstractIodosobenzene bis(trifluoroacetate)‐mediated cyclization of pyridyl‐ (I) and quinolinylhydrazones (III) proceeds by simple grinding under neat conditions within a few minutes.
ChemInform Abstract: Construction of Pyrazolo[3,4‐b]pyridines and Pyrazolo[4,3‐c]pyridines by Ring Closure of 3‐Acylpyridine N‐Oxide Tosylhydrazones.
Authors: Lominac William J. , D'Angelo Megan L. , Smith Mark D. , Ollison Darius A. , Hanna James M. Jr. 
Published: May 2012

AbstractReaction conditions for the cyclization of (Z)‐hydrazones (I) are optimized.
ChemInform Abstract: Synthesis and Antibacterial Activity of Naphthyridone Derivatives Containing Mono/Difluoro‐methyloxime Pyrrolidine Scaffolds.
Authors: Lv Kai , Liu Ming‐Liang , Feng Lian‐Shun , Sun Lan‐Ying , Sun Ye‐Xin , Wei Zeng‐Quan , Guo Hui‐Quan 
Published: May 2012

AbstractNew pyrrolidine derivatives (VII) as well as novel naphthyridones (XI) are synthesized.
ChemInform Abstract: Trifluoroethanol as a Metal‐Free, Homogeneous, and Recyclable Medium for the Efficient One‐Pot Synthesis of Dihydropyrimidones.
Authors: Rashmi S. V. , Sandhya N. C. , Raghava B. , Kumara M. N. , Mantelingu K. , Rangappa K. S. 
Published: May 2012

AbstractTrifluoroethanol acts as solvent and reaction mediator at the same time, hence no further activator is required.
ChemInform Abstract: Three‐Component Domino Synthesis of 2‐Arylquinazoline‐4‐amines in One‐Pot by Activating an sp3 C—H Bond in a Nonmetal Catalytic Oxidation System.
Authors: Zeng Li‐Yan , Yi Wen‐Bin , Cai Chun 
Published: May 2012

AbstractA one‐pot iodine‐catalyzed amination of benzoxazine diones (I) and (V) with aromatic amines (II), followed by TBHP‐mediated oxidative cyclization with benzylic amines (III), provides access towards title quinazolinamines (IV) and (VI) in moderate yields.
ChemInform Abstract: Novel Variant of the ANRORC Rearrangement of [1,2,4]Triazolo[1,5‐a]pyrimidines and Pyrimido[1,2‐a]benzimidazole.
Authors: Potapov A. Yu. , Romanov P. S. , Shikhaliev Kh. S. , Polunin E. V. , Firgang S. I. 
Published: May 2012

AbstractThe alkaline hydrolysis reaction of esters (I) and (III) proceeds with ANRORC rearrangement to give methyl ketones (II) and (IV), respectively.
ChemInform Abstract: A Facile and Highly Atom‐Economic Approach to Biaryl‐Containing Medium‐Ring Bislactones
Authors: Wu Dongdong , Wang Lei , Xu Kai , Song Jia , Fun Hoong‐Kun , Xu Jianhua , Zhang Yan 
Published: May 2012

Abstractusing a photocycloaddition/photooxidation approach
ChemInform Abstract: An Efficient Oxa‐Michael Addition to Diethyl Vinylphosphonate under Mild Reaction Conditions.
Authors: Baszczynski Ondrej , Jansa Petr , Dracinsky Martin , Kaiser Martin Maxmilian , Spacek Petr , Janeba Zlatko 
Published: May 2012

AbstractVinylphosphonate (II) is added to secondary and sterically hindered primary alcohols under optimized conditions to give the corresponding 2‐(alkoxy)ethylphosphonates, including biologically active compounds.
ChemInform Abstract: PEG—SO3H Catalyzed Synthesis and Cytotoxicity of α‐Aminophosphonates.
Authors: Reddy C. Devendranath , et al. et al. 
Published: May 2012

AbstractThe one‐pot, three‐component reaction of (pyridinyl)benzaldehyde (I) with primary amines (II) and triethyl phosphite (III) is carried out in the presence of polyethylene glycol sulfonic acid as a recyclable catalyst under mild conditions to provide a new structurally diversified set of α‐aminophosphonates (IV) which is evaluated for their anti‐tumor activity on human leukemia and colon carcinoma cells together with non‐cancerous human embryonic kidney cells.
ChemInform Abstract: 1,2,4‐Triazole D‐Ribose Derivatives: Design, Synthesis and Antitumoral Evaluation.
Authors: Avanzo Romina E. , Anesini Claudia , Fascio Mirta L. , Errea Maria I. , D'Accorso Norma B. 
Published: May 2012

AbstractAntitumoral screening shows moderate antiproliferative activity against T cell lymphoma cell lines for several triazole D‐ribose derivatives, e.g. compounds (III), (V), and (XIII).
ChemInform Abstract: Photogenerated Avenues in Macromolecules Containing Re(I), Ru(II), Os(II), and Ir(III) Metal Complexes of Pyridine‐Based Ligands
Authors: Happ Bobby , Winter Andreas , Hager Martin D. , Schubert Ulrich S. 
Published: May 2012

AbstractReview: 223 refs.
Determination of enantiomeric impurity in besifloxacin hydrochloride by chiral high‐performance liquid chromatography with precolumn derivatization
Authors: Wang Zhangting , Wang Shengjia , Zhu Feng , Chen Zaixin , Yu Lushan , Zeng Su 
Published: May 2012

AbstractBesifloxacin hydrochloride is a novel chiral broad‐spectrum fluoroquinolone developed for the treatment of bacterial conjunctivitis. R‐besifloxacin hydrochloride is used in clinics as a consequence of its higher antibacterial activity. To establish an enantiomeric impurity determination method, some chiral stationary phases (CSPs) were screened. Besifloxacin enantiomers can be separated to a certain extent on Chiral CD‐Ph (Shiseido Co., Ltd., Japan), Chiral AGP, and Crownpak CR (+) (Daicel Chemical IND., Ltd., Japan). However, the selectivity and sensitivity were both unsatisfactory on these three CSPs. Therefore, Chiral AGP, Chiral CD‐Ph, and Crownpak CR (+) were not used in the enantiomeric impurity determination of besifloxacin hydrochloride. The separation of enantiomers of besifloxacin was further performed using a precolumn derivatization chiral high‐performance liquid chromatography method. 2,3,4,6‐Tetra‐O‐acetyl‐beta‐D‐glucopyranosyl isothiocyanate was used as the derivatization reagent. Besifloxacin enantiomer derivates were well separated on a C18 column (250 × 4.6 mm, 5 µm) with a mobile phase that consisted of methanol‐KH2PO4 buffer solution (20 mM; pH 3.0) (50:50, v/v). Selectivity, sensitivity, linearity, accuracy, precision, stability, and robustness of this method were all satisfied with the method validation requirement. The method was suitable for the quality control of enantiomeric impurity in besifloxacin hydrochloride. Chirality 24:526–531, 2012. © 2012 Wiley Periodicals, Inc.
A new approach for joint modelling of longitudinal measurements and survival times with a cure fraction
Authors: Song Hui , Peng Yingwei , Tu Dongsheng 
Published: May 2012

AbstractThe joint analysis of longitudinal measurements and survival data is useful in clinical trials and other medical studies. In this paper, we consider a joint model which assumes a linear mixed$tt$model for longitudinal measurements and a promotion time cure model for survival data and links these two models through a latent variable. A semiparametric inference procedure with an EM algorithm implementation is developed for the parameters in the joint model. The proposed procedure is evaluated in a simulation study and applied to analyze the quality of life and time to recurrence data from a clinical trial on women with early breast cancer.The Canadian Journal of Statistics40: 207–224; 2012 © 2012 Statistical Society of Canada
Tivantinib (ARQ 197), a selective inhibitor of MET, in patients with microphthalmia transcription factor–associated tumors
Authors: Wagner Andrew J. , Goldberg John M. , DuBois Steven G. , Choy Edwin , Rosen Lee , Pappo Alberto , Geller James , Judson Ian , Hogg David , Senzer Neil , Davis Ian J. , Chai Feng , Waghorne Carol , Schwartz Brian , Demetri George D. 
Published: May 2012

AbstractBACKGROUND:Microphthalmia transcription factor (MITF)‐associated (MiT) tumors are a family of rare malignancies, including alveolar soft part sarcoma (ASPS), clear cell sarcoma (CCS), and translocation‐associated renal cell carcinoma (tRCC) that have dysregulated expression of oncogenic MITF family proteins. The MET receptor tyrosine kinase gene is transcriptionally activated by MITF family proteins, making MET a potential therapeutic target for MiT tumors. This study assessed the activity of tivantinib (ARQ 197), a selective MET inhibitor, in patients with MiT‐associated tumors.METHODS:This multicenter, single‐arm, phase 2 trial enrolled patients with advanced MiT tumors. Patients initially received tivantinib 120 mg orally twice daily, then 360 mg twice daily per protocol amendment. The primary endpoint was overall response rate. Secondary endpoints included safety, progression‐free survival, pharmacokinetics, and correlative studies.RESULTS:A total of 47 patients (median age, 25 years; range, 11‐73 years) with ASPS (n = 27), CCS (n = 11), tRCC (n = 6), or other tumor types (n = 3) were enrolled. Common grade 3/4 drug‐related adverse events included anemia (4%) and neutropenia (4%). Three patients (6.4%) experienced 4 treatment‐related serious adverse events (grade 3 febrile neutropenia, thrombocytopenia, and deep vein thrombosis, and grade 4 thrombocytopenia). Best response was partial response in 1 CCS patient (2%) and stable disease in 28 patients (60%). Median progression‐free survival was 3.6 months (overall), 5.5 months (ASPS), and 1.9 months (CCS and tRCC). Baseline MET expression was strongly or focally positive in tumor samples from 14 of 19 patients (74%).CONCLUSIONS:Tivantinib was safe and tolerable in patients with MiT tumors, but antitumor activity was modest. Cancer 2012. © 2012 American Cancer Society.
Driver mutations determine survival in smokers and never‐smokers with stage IIIB/IV lung adenocarcinomas
Authors: Paik Paul K. , Johnson Melissa L. , D'Angelo Sandra P. , Sima Camelia S. , Ang Daphne , Dogan Snjezana , Miller Vincent A. , Ladanyi Marc , Kris Mark G. , Riely Gregory J. 
Published: May 2012

AbstractBACKGROUND:The authors previously demonstrated that never‐smokers with stage IIIB/IV nonsmall cell lung cancer (NSCLC) lived 50% longer than former/current smokers. This observation persisted after adjusting for age, performance status, and sex. In this study, the authors hypothesized that smoking‐dependent differences in the distribution of driver mutations may explain differences in prognosis between these subgroups.METHODS:In total, 293 never‐smokers and 382 former/current smokers with lung adenocarcinoma who underwent testing for epidermal growth factor receptor (EGFR) mutations and v‐Ki‐ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations and rearrangements in anaplastic lymphoma kinase (ALK) between 2009 and 2010 were investigated. Clinical outcomes and patient characteristics were collected. Survival probabilities were estimated using the Kaplan‐Meier method. Group comparison was performed with log‐rank tests and Cox proportional hazards methods.RESULTS:Although the overall incidence of these mutations was nearly identical (55% never‐smokers vs 57% current/former smokers; P = .48), there were significant differences in the distribution of mutations between these groups for EGFR mutations (37% never‐smokers vs 14% former/current smokers; P < .0001), KRAS mutations (4% never‐smokers vs 43% former/current smokers; P < .0001), and ALK rearrangements (12% never‐smokers vs 2% former/current smokers; P < .0001). Among never‐smokers and former/current smokers, the prognosis differed significantly by genotype. Patients who had KRAS mutations had the poorest survival. Smoking status, however, had no influence on survival within each genotype.CONCLUSIONS:Never‐smokers and former/current smokers with lung adenocarcinomas were not homogeneous subgroups. Each was made up of individuals whose tumors had a unique distribution of driver mutations, which were associated with different prognoses, irrespective of smoking history. Cancer 2012. © 2012 American Cancer Society.
Cytopathologic evaluation of the in situ margin in patients undergoing hepatectomy
Authors: Jones Natalie B. , Wakely Paul E. , Klemanski Dori L. , Al‐Saif Osama , Young Gregory , Frankel Wendy L. , Martin Edward W. , Bloomston Mark 
Published: May 2012

AbstractBACKGROUND:Margin status is a predictor of outcome for patients with liver malignancies, although what constitutes a negative margin is controversial. Traditionally, the completeness of resection is estimated by surgical histopathology of the resected specimen margin, despite the in situ margin being potentially more important. The true margin is often altered by parenchymal transection techniques. The authors propose that cytologic assessment of the in situ margin is more specific for determining the true margin.METHODS:A total of 84 patients with primary or metastatic liver tumors who were undergoing surgical resection were enrolled in this prospective Institutional Review Board‐approved study. Specimen and in situ (patient) margins were assessed using a “scrape preparation” cytologic technique and compared with traditional surgical histopathology. Patients were followed for assessment of local disease recurrence.RESULTS:Follow‐up data were complete for 64 patients for a median of 37 months (range, 12 months‐56 months). Twenty patients were excluded because of perioperative death (6 patients; 7%) or a follow‐up of < 12 months. Seven patients (12.2%) had positive histopathologic specimen margins, but only 1 was found to be positive by cytology (1.8%). No in situ cytologically positive margins were identified along the cut edge of the liver remnant. The rate of intra‐ or extrahepatic recurrences was 56.7%, whereas the local recurrence rate was 1.8%. One patient with local recurrence demonstrated simultaneous intra‐ and extrahepatic disease recurrences and had negative margins by all methods of evaluation.CONCLUSIONS:To the authors' knowledge, the current study is the first to demonstrate that in situ margins can be assessed using cytopathology. This method is quick and can be universally applied. Given the difficulty of accurately assessing margins after hepatectomy, cytopathologic evaluation may be more reflective of the true margin. Cancer (Cancer Cytopathol) 2012. © 2012 American Cancer Society.
Validity of the Generalized Anxiety Disorder‐7 Scale in an Acute Psychiatric Sample
Authors: Kertz Sarah , Bigda‐Peyton Joe , Bjorgvinsson Throstur 
Published: May 2012

Generalized anxiety disorder (GAD) is one of the most prevalent psychiatric presentations; however, GAD has the lowest diagnostic reliability of the anxiety disorders and is poorly recognized in clinical practice. A more reliable assessment of GAD could lead to earlier detection and treatment of the disorder, which has an otherwise debilitating course and significant associated impairment. The 7‐item GAD Scale (GAD‐7) has shown promise as a measure with good clinical utility and strong psychometric properties in primary care and community settings but has yet to be assessed in acute psychiatric populations. This study examined the validity of the GAD‐7 in a sample of 232 patients enrolled in a partial hospital programme. Patients completed a diagnostic interview and a battery of self‐report measures before and after treatment. Findings suggest that the GAD‐7 has good internal consistency and good convergent validity with worry, anxiety, depression and stress, and the measure was sensitive to change over the course of a short intensive cognitive–behavioural therapy partial hospital programme. However, the confirmatory analysis failed to support the hypothesized unidimensional factor structure; and although the GAD‐7 demonstrated good sensitivity (.83), specificity was poor (.46) in identifying patients with GAD. Overall, the GAD‐7 appears to be a valid measure of generalized anxiety symptoms in this sample, on the basis of good internal consistency, convergent validity and sensitivity to change, but does not perform well as a screener for GAD. Copyright © 2012 John Wiley & Sons, Ltd.Key Practitioner Message

The GAD‐7 Scale is an easy‐to‐score, self‐report measure of core generalized anxiety disorder symptoms.
The GAD‐7 Scale has good internal consistency and convergent validity with depression, anxiety, stress and worry, and is sensitive to change.
The GAD‐7 Scale appears to be a good measure of generalized anxiety symptoms in an acute psychiatric sample.
The GAD‐7 Scale does not perform well as a screener for GAD and should not be used to identify cases of GAD in acute psychiatric samples.
Research analysis of wireless localization with insufficient resources for next‐generation mobile communication networks
Authors: Cui Qimei , Zhang Xuefei 
Published: May 2012

SUMMARYThe paper proposes a cooperative group location (CGL) scheme to solve the ill‐conditioned location problem in mobile communication networks, which means that the mobile terminal (MT) has no sufficient signal resources from the networks to uniquely localize itself. On the basis of rigid graph theory, the unique solvability of the CGL scheme is completely proved in the theory in this paper. In CGL, it is assumed that the different MTs can directly communicate with each other in a peer‐to‐peer manner and form a terminal group (TG), which is propelled by some distinct characteristics of next‐generation wireless networks such as ubiquitous inter‐net and inter‐communicating, device‐to‐device connectivity, and so on. When each MT in a TG has no sufficient signal resources, the CGL scheme makes it possible to accurately locate all the MTs in the TG. Two CGL‐based location algorithms—improved Taylor‐series iteration location algorithm and search and positioning algorithm, are presented in this paper. The numerical simulation results indicate that the proposed algorithms have higher positioning accuracy over traditional geometric location methods in ill conditions. The CGL scheme can effectively enhance the robustness and precision of localization and provide a novel idea to the positioning of MTs in next‐generation mobile communication networks. Copyright © 2012 John Wiley & Sons, Ltd.
Thinking about Arabs and Muslims makes Americans shoot faster: Effects of category accessibility on aggressive responses in a shooter paradigm
Authors: Mange Jessica , Chun Woo Young , Sharvit Keren , Belanger Jocelyn J. 
Published: May 2012

AbstractIs the same person perceived as more dangerous if the perceiver is induced to think about Arab and Muslim categories versus no category? Using the shooter paradigm, this study investigated the effects of the accessibility of ethnic (Arab) versus religious (Muslim) categories versus no category on spontaneous aggressive responses toward a target with an ambiguous appearance. Results demonstrated that shooting reactions toward armed targets were faster than non‐shooting reactions toward unarmed targets, especially if the target was a man. Despite these main effects, participants made faster decisions to shoot an ambiguous armed target if primed with the category Arab or Muslim (versus no category priming). The findings indicate that the mere priming of these social categories is sufficient to facilitate aggressive responses, even if the targets themselves are ambiguous. Copyright © 2012 John Wiley & Sons, Ltd.
Dissolved organic matter reduces algal accumulation of methylmercury
Authors: Luengen Allison C. , Fisher Nicholas S. , Bergamaschi Brian A. 
Published: May 2012

Abstract
Dissolved organic matter (DOM) significantly decreased accumulation of methylmercury (MeHg) by the diatom Cyclotella meneghiniana in laboratory experiments. Live diatom cells accumulated two to four times more MeHg than dead cells, indicating that accumulation may be partially an energy-requiring process. Methylmercury enrichment in diatoms relative to ambient water was measured by a volume concentration factor (VCF). Without added DOM, the maximum VCF was 32 × 104, and the average VCF (from 10 to 72 h) over all experiments was 12.6 × 104. At very low (1.5 mg/L) added DOM, VCFs dropped by approximately half. At very high (20 mg/L) added DOM, VCFs dropped 10-fold. Presumably, MeHg was bound to a variety of reduced sulfur sites on the DOM, making it unavailable for uptake. Diatoms accumulated significantly more MeHg when exposed to transphilic DOM extracts than hydrophobic ones. However, algal lysate, a labile type of DOM created by resuspending a marine diatom in freshwater, behaved similarly to a refractory DOM isolate from San Francisco Bay. Addition of 67 µM L-cysteine resulted in the largest drop in VCFs, to 0.28 × 104. Although the DOM composition influenced the availability of MeHg to some extent, total DOM concentration was the most important factor in determining algal bioaccumulation of MeHg. Environ. Toxicol. Chem. 2012; 31: 1712–1719. © 2012 SETAC