bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inmunización contra el COVID-19 y su relación con el desarrollo de lesiones dermatólogas: reporte de un caso de liquen plano
Authors: Jami Carrera Jeanneth Elizabeth , Tixilema Arias Luis Alexander , Tipantasig Paucar Lissbeth Giomara 
Published: May 2024

Introducción: El liquen plano, es una dermatitis inflamatoria que afecta adultos de mediana edad, se presenta como pápulas violáceas en áreas como muñecas y cuello. Su etiología no está clara, pero se sugiere reactividad cruzada entre antígenos desencadenados por diversas causas. Se plantea la asociación de reacciones hiperinflamatorias con el SARS-CoV-2, demostrando lesiones LP-Like. La presencia de eosinófilos y paraquetosis guía el diagnóstico de erupciones liquenoides, indistinguibles del liquen plano. Teorías sobre la relación entre la vacuna COVID-19 y dermatosis autoinmunes incluyen reacción cruzada y predisposición genética. Las vacunas involucradas, especialmente Pfizer, podrían desencadenar respuestas inmunológicas asociadas a trastornos autoinmunitarios. La aparición temporal de enfermedades ampollares sugiere una posible relación causal con la vacunación COVID-19.
Objetivo general: : Determinar, a través de la presentación de un caso clínico, la relación entre la respuesta inmunológica producida por la inmunización contra COVID-19 y el posterior desarrollo de liquen plano.
Objetivos específicos: 1) Describir los procesos inmunológicos involucrados en la patogenia del liquen plano. 2) Identificar las posibles vacunas relacionadas con el aparecimiento de la patología dermatológica.
Materiales y métodos: Por medio del examen histopatològico que confirma el diagnostico; se obtuvo autorizaciòn de la unidad de salud para analisis y publicaciòn.
Resultados: El liquen plano es una enfermedad inflamatoria cutánea que ha sido vinculado con la administración de vacunas contra el COVID-19 en diversos casos documentados globalmente. Estas reacciones muestran características típicas, como pápulas pruriginosas, ocurriendo en brazos, tronco y extremidades inferiores. Se postula un fenómeno de mimetismo molecular, donde un epítopo viral desencadena respuestas inmunológicas en queratinocitos. Aunque la mayoría de los casos de liquen plano carece de desencadenantes conocidos, se han identificado algunos asociados a vacunas antivirales, incluida la del VHB. La secuencia temporal entre la vacunación y la dermatosis, aproximadamente 4 semanas, respalda la posible relación causal entre la vacuna inactiva del SARS-COV-2 y el liquen plano observado en la paciente.
Conclusiones: La vacuna contra el SARS-CoV-2 puede provocar reacciones en diversos tejidos, como se observa en el caso presentado con lesiones cutáneas similares al liquen plano. Destaca la importancia de registrar la vacunación en la anamnesis dermatológica para evitar malinterpretaciones y reconocer efectos secundarios cutáneos
PENGARUH UKURAN BANK, KREDIT, KREDIT BERMASALAH, MODAL DAN PRODUK DOMESTIK BRUTO TERHADAP PENGAMBILAN RISIKO BANK
Authors: Tandeas Fiona , Setyawan Agustinus 
Published: May 2024

Penelitian ini mempunyai tujuan untuk menguji pengaruh dari Ukuran Bank, Kredit, Kredit Bermasalah, Modal, Produk Domestik Bruto pada pengambilan risiko Bank. Data pada penelitian ini diperoleh dari laporan keuangan perbankan selama 5 periode, dari tahun 2018–2022 yang diunduh di situs www.idx.co.id. Untuk jumlah sample yang digunakan sebanyak 50 data dari 10 entitas subsektor perbankan, setelah dilakukan purposive sampling dengan jenis data sekunder. Hasil penelitian menggunakan PYTHON yang menunjukkan bahwa ukuran bank (SIZE) dan kredit bermasalah (NPL) berpengaruh negatif terhadap pengambilan risiko bank. Sedangkan untuk kredit (LDR), modal (CAR), dan produk domestik bruto (PDB) tidak berpengaruh signifikan terhadap pengambilan risiko Bank.
Penerapan Pendekatan Realistic Mathematics Education Dalam Pembelajaran Matematika Materi Persamaan Garis Lurus di SMP Kristen Tomohon
Authors: Kaunang Derel Filandy 
Published: May 2024

Penelitian ini dilaksanakan dengan tujuan untuk mengetahui perbedaan hasil belajar siswa yang diajarkan dengan pendekatan Realistic Mathematics Education (RME) dan siswa yang diajarkan dengan pembelajaran langsung pada materi persamaan garis lurus di kelas VIII SMP. Penelitian ini menggunakan metode true experimental. Populasi yang diambil adalah seluruh siswa kelas VIII SMP Kristen Tomohon yang terdiri dari enam kelas sedangkan sampel yang diambil secara acak adalah dua kelas yang homogen yaitu kelas VIIIA sebagai kelas eksperimen dan kelas VIIIB sebagai kelas kontrol. Kelas eksperimen terdiri dari 24 orang siswa dan kelas kontrol terdiri dari 24 orang siswa. Penelitian ini merupakan model rancangan Pretest-Posttest Control Group Design. Data diambil dan dikumpulkan dari tes hasil belajar siswa. Data dalam penelitian ini adalah selisih hasil belajar siswa yang diperoleh dari skor pretes dan posttest pada materi persamaan garis lurus. Berdasarkan analisis data dengan uji t diperolah bahwa thitung = 2,824 > ttabel = 2,013 untuk α = 0,05. Berdasarkan hasil penelitian maka dapat diambil kesimpulan bahwa rata-rata hasil belajar siswa yang diajarkan dengan pendekatan Realistic Mathematics Education (RME) lebih tinggi dari rata-rata hasil belajar siswa yang diajarkan dengan dengan pembelajaran langsung.
This research aims to investigate the difference between students' learning outcomes taught by the Realistic Mathematics Education (RME) approach and the students taught by direct learning on the equation of a straight line in class VIII SMP. This research uses a true experimental method. The population is all students of class VIII SMP Kristen Tomohon consists of six classes while the the random samples are two homogeneous classes which are class VIIIA as an experiment class and class VIIIB as a control class. The experimental class consists of 24 students and the control class consists of 24 students. This research is a design model of Pretest-Posttest Control Group Design. The data are gathered and collected from students' learning outcomes. The data in this research are the differences in the students' learning results obtained from the pretest and post-test scores on the equation of straight-line equation. Furthermore, the data analysis with t-test is tcount = 2,824 > ttable = 2.013 for α = 0,05. Based on the result of this research, it can be concluded that the average of student learning outcomes taught with the Realistic Mathematics Education (RME) approach is higher than the average of student learning outcomes taught with direct learning.
Massage on the prevention of breast cancer through stress reduction and enhancing immune system
Authors: Siregar Zilhana , Usman Andi Nilawati , Ahmad Mardiana , Ariyandy Andi , Ilhamuddin Ilhamuddin , Takko A.B. 
Published: May 2024

INTRODUCTION: Housewives are a population at high risk of breast cancer due to repeated or chronic exposure to stress. Prevention in a simple yet evidence-based manner is needed. METHODS: This study is a narrative review of the potential of massage as breast cancer prevention through stress and immune system mechanisms. RESULTS: Massage is able to prevent chronic stress through improved sleep and fatigue and lower stress levels. Prevention of chronic stress will maximize the function of cells that eliminate cancer cells, such as B cells, T cells, and natural killer (NK) cells, and improve the balance of Foxp3 Tregulator cells. Partnered delivery massage will bring effective benefits for stress reduction. CONCLUSIONS: Massage can provide indirect prevention of breast cancer, and partnered delivery massage can be a good choice to reduce stress.
Informal Caregivers of People with Dementia in Germany: Psychosocial Characteristics and Unmet Needs
Authors: Thyrian Jochen René , Boekholt Melanie , Biernetzky Olga , Blotenberg Iris , Teipel Stefan , Killimann Ingo , Hoffmann Wolfgang 
Published: May 2024

Background: Caregivers of people with dementia living at home (CPwDh) are likely to be affected by a range of health problems. However, CPwDh are often regarded as accompanying persons and receive less attention in research and care. Little is known about this population and their needs in Germany. However, better knowledge of CPwDH is needed to design effective interventions. Objective: The objective of this report is to describe the situation of CPwDh and highlight differences based on sex and living situation. Methods: This was a cross-sectional analysis of the psychosocial characteristics of participants in the GAIN trial, a cluster-randomized, controlled intervention trial investigating the effectiveness of a care management program. A total of n = 192 CPwDh were recruited in GP offices, memory clinics or through public campaigns in the German federal state of Mecklenburg-Western Pomerania. The inclusion criteria were an age of 18 years or above, being a CPwDh, written informed consent. In a comprehensive digital assessment, psychosocial variables, burden, and care needs were assessed. Results: Partners, women, and people living in the same household represented the majority of caregivers, and their mean number of needs was 8.7. Overall, participants indicated a mild to moderate burden. There are differences in burden based on sex and living situation, with caregivers living with people with dementia showing less burden and different psychosocial demographics. Conclusions: There is a need for interventions to reduce caregivers’ unmet needs in the CPwDh. Such interventions should consider differences in sex and living situation to better address individual caregiver needs.
Semantic Harmonization of Alzheimer’s Disease Datasets Using AD-Mapper
Authors: Wegner Philipp , Balabin Helena , Ay Mehmet Can , Bauermeister Sarah , Killin Lewis , Gallacher John , Hofmann-Apitius Martin , Salimi Yasamin ,   for the Alzheimer’s Disease Neuroimaging Initiative,   the Japanese Alzheimer’s Disease Neuroimaging Initiative,   the Aging Brain: Vasculature, Ischemia, and Behavior Study,   the Alzheimer’s Disease Repository Without Borders Investigators,   the European Prevention of Alzheimer’s Disease (EPAD) Consortium
Published: May 2024

Background: Despite numerous past endeavors for the semantic harmonization of Alzheimer’s disease (AD) cohort studies, an automatic tool has yet to be developed. Objective: As cohort studies form the basis of data-driven analysis, harmonizing them is crucial for cross-cohort analysis. We aimed to accelerate this task by constructing an automatic harmonization tool. Methods: We created a common data model (CDM) through cross-mapping data from 20 cohorts, three CDMs, and ontology terms, which was then used to fine-tune a BioBERT model. Finally, we evaluated the model using three previously unseen cohorts and compared its performance to a string-matching baseline model. Results: Here, we present our AD-Mapper interface for automatic harmonization of AD cohort studies, which outperformed a string-matching baseline on previously unseen cohort studies. We showcase our CDM comprising 1218 unique variables. Conclusion: AD-Mapper leverages semantic similarities in naming conventions across cohorts to improve mapping performance.
Using paradata to assess respondent burden and interviewer effects in household surveys: Evidence from low- and middle-income countries
Authors: Hasanbasri Ardina , Kilic Talip , Koolwal Gayatri , Moylan Heather 
Published: May 2024

Over the past decade, national statistical offices in low- and middle-income countries have increasingly transitioned to computer-assisted personal interviewing and computer-assisted telephone interviewing for the implementation of household surveys. The byproducts of these types of data collection are survey paradata, which can unlock objective, module- and question-specific, actionable insights on survey respondent burden, survey costs, and interviewer effects – all of which have been understudied in low- and middle-income contexts. This study uses paradata generated by Survey Solutions, a computer-assisted personal interviewing platform used in recent national household surveys implemented by the national statistical offices of Cambodia, Ethiopia, and Tanzania. Across countries, the average household interview, based on a socioeconomic household questionnaire, ranges from 82 to 120 minutes, while the average interview with an adult household member, based on a multi-topic individual questionnaire, takes between 13 to 25 minutes. The paper further provides guidelines on the use of paradata for module-level analysis to aid in operational survey decisions, such as using interview length to estimate unit cost for budgeting purposes as well as understanding interviewer effects using a multilevel model. Our findings, particularly by module, point to where additional interviewer training, fieldwork supervision, and data quality monitoring may be needed in future surveys.
Body Shaming Berhubungan Dengan Mekanisme Koping Pada Remaja Di SMK Winongan Pasuruan Kabupaten Pasuruan
Authors: Nurheni Nurheni , Rosdiana ( ID SINTA : 6725591 ) Yanti , Parnawati Tantry Ajeng 
Published: May 2024

Dunia pendidikan saat ini menjadi bahan perbincangan tentang maraknya permasalahan sosial, salah satunya adalah kasus body shaming, diperlukan upaya pencegahan melalui mekanisme koping. Penelitian ini bertujuan untuk mengetahui hubungan body shaming dengan mekanisme koping pada remaja di SMKN Winongan Pasuruan Kabupaten Pasuruan Jawa Timur. Desain penelitian mengunakan cross sectional. Desain penelitian menggunakan observasi analitik dengan pendekatan cross sectional, populasi penelitian ini sebanyak 84 siswa dengan jumlah sampel sebanyak 69 siswa. Sampel diambil dengan teknik purposive sampling. Variabel independen adalah body shaming, variabel dependen adalah mekanisme koping. Instrumen yang digunakan berupa lembar kuesioner body shaming among university students dan lembar kuesioner brief-coping orientation to problems experienced. Analisis menggunakan univariat dan bivariat dengan uji spearman. Hasil penelitian ini menunjukkan bahwa sebagian besar responden memiliki body shaming pada kategori rendah (78,3%); sebagian besar responden memiliki mekanisme koping adaptif (81,2%). Ada hubungan body shaming dengan mekanisme koping pada remaja di SMKN Winongan Pasuruan Kabupaten Pasuruan Jawa Timur (ρ= 0,000). Penelitian selajutnya dapat melakukan penelitian tetang faktor lainya yang dapat mempengaruhi body shaming dan mekanisme koping seperti harapan dan optimisme responden
Kesalahan Penggunaan Teknik Sampling Pada Penelitian Kuantitatif Di Bidang Ilmu Keperawatan
Authors: Choeron Rachmat Chusnul , Nofiana Ika 
Published: May 2024

Salah satu indikator kualitas penelitian kuantitatif ialah ketepatan dalam menggunakan teknik sampling, yaitu probability sampling. Namun, masih banyak ditemukan penelitian kuantitatif yang belum mengikuti kaidah randomisasi. Tujuan penelitian ini adalah untuk mengetahui kesalahan penggunaan teknik sampling pada penelitian kuantitatif. Desain penelitian ini menggunakan desain deskriptif kuantitatif. Penelitian ini dilakukan pada hasil-hasil penelitian kuantitatif yang telah dipublikasikan pada jurnal-jurnal keperawatan Sinta 2. Variabel pada penelitian ini adalah penggunaan teknik sampling. Populasi dalam penelitian ini adalah semua hasil penelitian kuantitatif yang dipublikasikan pada jurnal keperawatan sinta 2 yang memenuhi kriteria. Sampel sebanyak 47 hasil penelitian diambil dengan teknik cluster sampling, yaitu memilih secara acak jurnal keperawatan sinta 2 dan mengambil semua artikel hasil penelitian yang ada pada jurnal terpilih hingga jumlah sampel terpenuhi. Data dikumpulkan menggunakan lembar check list. Data yang terkumpul dianalisis menggunakan uji univariate. Hasil penelitian ini didapatkan bahwa hampir seluruh hasil penelitian kuantitatif yang telah dipublikasikan pada jurnal terakreditasi kemenristekdikti memiliki kesalahan dalam penggunaan teknik sampling, yaitu sebanyak 38 jurnal (80,85%). Teknik sampling yang paling banyak digunakan adalah nonprobability sampling, yaitu purposive sampling (47,37%) dan consecutive sampling (42,11%). Pemahaman terhadap teknik sampling perlu ditingkatkan kembali melalui seminar atau pelatihan agar dapat menyempurnakan hasil penelitian kuantitatif yang dilakukan oleh para peneliti.
Effects of IMU sensor-to-segment calibration on clinical 3D elbow joint angles estimation
Authors: Bonfiglio Alessandro , Tacconi David , Bongers Raoul M. , Farella Elisabetta 
Published: May 2024

Introduction: Inertial Measurement Units (IMU) require a sensor-to-segment calibration procedure in order to compute anatomically accurate joint angles and, thereby, be employed in healthcare and rehabilitation. Research literature proposes several algorithms to address this issue. However, determining an optimal calibration procedure is challenging due to the large number of variables that affect elbow joint angle accuracy, including 3D joint axis, movement performed, complex anatomy, and notable skin artefacts. Therefore, this paper aims to compare three types of calibration techniques against an optical motion capture reference system during several movement tasks to provide recommendations on the most suitable calibration for the elbow joint.Methods: Thirteen healthy subjects were instrumented with IMU sensors and optical marker clusters. Each participant performed a series of static poses and movements to calibrate the instruments and, subsequently, performed single-plane and multi-joint tasks. The metrics used to evaluate joint angle accuracy are Range of Motion (ROM) error, Root Mean Squared Error (RMSE), and offset. We performed a three-way RM ANOVA to evaluate the effect of joint axis and movement task on three calibration techniques: N-Pose (NP), Functional Calibration (FC) and Manual Alignment (MA).Results: Despite small effect sizes in ROM Error, NP displayed the least precision among calibrations due to interquartile ranges as large as 24.6°. RMSE showed significant differences among calibrations and a large effect size where MA performed best (RMSE = 6.3°) and was comparable with FC (RMSE = 7.2°). Offset showed a large effect size in the calibration*axes interaction where FC and MA performed similarly.Conclusion: Therefore, we recommend MA as the preferred calibration method for the elbow joint due to its simplicity and ease of use. Alternatively, FC can be a valid option when the wearer is unable to hold a predetermined posture.
Prognostic significance of compliance with fractional flow reserve guidance on diverse vessel-related clinical outcomes
Authors: Zhang Yang , Yang Bangguo , Ye Yicong , Zhao Xiliang , Ding Yaodong , Ye Yi , Zhang Liang , Tan Dawei , Zhang Gong , Duan Xiaoyu , Li Quan , Zeng Yong 
Published: May 2024

BackgroundIn patients underwent fractional flow reserve (FFR) assessment, a noteworthy proportion of adverse events occur in vessels in which FFR has not been measured. However, the effect of these non-target vessel-related events on the evaluation of FFR-related benefits remains unknown.Methods and resultsIn this retrospective study, vessels subjected to FFR measurement were grouped as FFR-based approach and non-compliance with FFR based on whether they received FFR-based treatment. Using inverse probability of treatment weighting (IPTW) to account for potential confounding, we investigated the association between compliance with FFR and 5-year target vessel failure (TVF) non-target vessel failure (NTVF) and vessel-oriented composite endpoints (VOCEs). Of the 1,119 vessels, 201 did not receive FFR-based treatment. After IPTW adjustment, a signiﬁcantly lower hazard of TVF was observed in the FFR-based approach group (HR: 0.56; 95% CI: 0.34–0.92). While, the intergroup difference in hazard of NTVF (HR: 1.02; 95% CI: 0.45–2.31) and VOCEs (HR: 0.69; 95% CI: 0.45–1.05) were nonsignificant.ConclusionsIn patients with CAD subjected to FFR, the FFR-based treatment yields a sustained clinical benefit in terms of the risks of target vessel-related events. The dilution of non-target vessel-related events renders the difference favoring the FFR-based approach nonsignificant.
Core-shell 3D printed biodegradable calcium phosphate cement—Alginate scaffolds for possible bone regeneration applications
Authors: Schweiker Clara , Zankovic Sergej , Baghnavi Anna , Velten Dirk , Schmal Hagen , Thomann Ralf , Seidenstuecker Michael 
Published: May 2024

The core/shell 3D printing process using CPC and alginate is intended to create biodegradable scaffolds that have a similar stability to bone tissue and also offer sufficient and continuous antibiotic release. In this way, a patient-specific and patient-friendly process will be established, which should optimally support the human organism in its regeneration. To generate the best possible strength values, the printed scaffolds underwent various post-treatments and were then tested in a material test. The test methods included self-setting, storage in a drying cabinet with a water-saturated atmosphere at 37°C, followed by incubation in PBS, freeze-drying, and coating the samples with alginate. Additionally, a degradation test at pH 7.4 and pH 5 was carried out to test stability under in vitro conditions. It was shown that the untreated and freeze-dried samples failed at a maximum load of 30–700 N, while the remaining scaffolds could withstand a load of at least 2,000 N. At this failure load, most of the test series showed an average deformation of 43.95%. All samples, therefore, remained below the strength of cancellous bone. However, based on a 20% load after surgery, the coated scaffolds represented the best possible alternative, with a Young’s modulus of around 1.71 MPa. We were able to demonstrate that self-setting occurs in core-shell printed CPC/alginate scaffolds after only 1 day, and that mass production is possible. By coating with alginate, the compressive strength could be increased without the need for additional post-treatment. The mechanical strength was sufficient to be available as a scaffold for bone regeneration and additionally as a drug delivery device for future applications and experiments.
Sex and age significantly modulate cardiovascular disease presentation in type 2 diabetes: a large population-based cohort study
Authors: Jiménez Amanda , Vlacho Bogdan , Mata-Cases Manel , Real Jordi , Mauricio Dídac , Franch-Nadal Josep , Ortega Emilio 
Published: May 2024

AimsWe aimed to describe and compare the incidence of the first cardiovascular event and its major subtypes, coronary heart disease (CHD), cerebrovascular disease, heart failure (HF), or peripheral artery disease (PAD), according to age and sex in a population-based cohort of individuals with type 2 diabetes (T2D) from a Mediterranean region.Material and methodsWe used linked primary care electronic medical reports, pharmacy-invoicing data, and hospital admission disease registry records from the SIDIAP database, which contains linked data for 74% of the Catalonian population. We selected individuals with T2D aged 30 to 89 years free of cardiovascular disease (CVD). The primary outcome was the first presentation of CVD.ResultsThe study cohort included 247,751 individuals (48.6% women, 66.8 ± 11.9 years). During a 6.99-year follow-up, the cumulative incidence of the first cardiovascular event was 23.4%. Men were at higher risk for CVD (hazard ratio [HR]: 1.47 95%CI: 1.45-1.50), CHD (HR: 1.52 95%CI: 1.47-1.57), cerebrovascular disease (HR:1.07 95%CI: 1.03-1.10) and PAD (HR: 2.30 95%CI: 2.21-2.39) than women but at a lower risk for HF (HR:0.70 95%CI: 0.68-0.73). CHD and PAD were the most frequent CVD presentations among men (28.1% and 27.5%) and HF (40.1%) in women. CHD predominated among young participants of both sexes, while HF predominated among women older than 65 and men older than 75.ConclusionsIn individuals with T2D, the overall risk and the type of first CVD manifestation largely varied by sex and age. This epidemiological evidence should be considered in clinical practice.