bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimizing fenugreek (Trigonella foenum-graecum L.) oil yield and compositions in intercropping through growth-promoting bacteria and mycorrhiza
Authors: Amiriyan Chelan Zahra , Amini Rouhollah , Dabbagh Mohammadi Nasab Adel 
Published: June 2024

IntroductionBiofertilizers and intercropping are two main components in sustainable production systems.Materials and methodsA two-year (2020–2021) study was conducted in East Azarbaijan, Iran, to evaluate the effects of arbuscular mycorrhizal fungi (AMF), growth-promoting bacteria (GPB) and chemical fertilizer (CF) on fenugreek (Trigonella foenum-graecum L.) (F) oil yield and compositions in intercropping with Moldavian balm (Dracocephalam mobdavica L.) (MB). The cropping patterns included MB sole cropping, fenugreek sole cropping (F) and replacement intercropping ratios consisted of Moldavian balm : fenugreek (MB:F (1:1)), MB:F (2:2) and MB:F (4:2) and additive intercropping of MB:F (100:50).ResultsFor both years, among the intercropping patters, the highest seed and oil yields were obtained in MB:F (100:50) intercropping pattern treated with CF and AMF+GPB. In all cropping patterns except MB:F (4:2), the highest anthocyanin, total flavonoid, and mucilage contents were observed in plants received AMF+GPB. At all treatments, the linoleic, oleic, and linolenic acid were the main components of fenugreek oil. In MB:F (1:1), (2:2), (4:2), and (100:50) intercropping patterns, the linoleic acid content in AMF+GPB treatment, increased by 9.45%, 6.63%, 15.20%, and 7.82%, respectively, compared with sole fenugreek. The highest total land equivalent ratio (LERT) values were obtained in 2021 and MB:F (100:50) intercropping pattern treated with CF (1.70) and AMF+GPB (1.63).ConclusionsIn general, it could be concluded that MB:F (100:50) intercropping pattern treated with AMF+GPB improved the oil yield and unsaturated fatty acid contents of fenugreek compared with sole cropping and could be recommended in sustainable production systems.
Systemic immune-inflammation index mediates the association between metabolic dysfunction-associated fatty liver disease and sub-clinical carotid atherosclerosis: a mediation analysis
Authors: Wang Wei , Guo Xiu Li , Qiu Xiu Ping , Yu Yun Jie , Tu Mei 
Published: June 2024

BackgroundLimited research has been conducted to quantitatively assess the impact of systemic inflammation in metabolic dysfunction-associated fatty liver disease (MAFLD) and sub-clinical carotid atherosclerosis (SCAS). The systemic immune-inflammation index (SII), which integrates inflammatory cells, has emerged as a reliable measure of local immune response and systemic inflammation Therefore, this study aims to assess the mediating role of SII in the association between MAFLD and SCAS in type 2 diabetes mellitus (T2DM).MethodThis study prospectively recruited 830 participants with T2DM from two centers. Unenhanced abdominal CT scans were conducted to evaluate MAFLD, while B-mode carotid ultrasonography was performed to assess SCAS. Weighted binomial logistic regression analysis and restricted cubic splines (RCS) analyses were employed to analyze the association between the SII and the risk of MAFLD and SCAS. Mediation analysis was further carried out to explore the potential mediating effect of the SII on the association between MAFLD and SCAS.ResultsThe prevalence of both MAFLD and SCAS significantly increased as the SII quartiles increased (P&lt;0.05). MAFLD emerged as an independent factor for SCAS risk across three adjusted models, exhibiting odds ratios of 2.15 (95%CI: 1.31–3.53, P &lt; 0.001). Additionally, increased SII quartiles and Ln (SII) displayed positive associations with the risk of MAFLD and SCAS (P &lt; 0.05). Furthermore, a significant dose-response relationship was observed (P for trend &lt;0.001). The RCS analyses revealed a linear correlation of Ln (SII) with SCAS and MAFLD risk (P for nonlinearity&lt;0.05). Importantly, SII and ln (SII) acted as the mediators in the association between MAFLD and SCAS following adjustments for shared risk factors, demonstrating a proportion-mediated effect of 7.8% and 10.9%.ConclusionSII was independently correlated with MAFLD and SCAS risk, while also acting as a mediator in the relationship between MAFLD and SCAS.
Implementation of an optimised tele-medicine platform for stroke in South Australia improves patient care
Authors: Kurunawai Craig , Chen Chushuang , Willcour Matthew , Tan Aaron , Mahadevan Joshua , Waters Michael , Harvey Jackson , Van Eunen Joanne , Dixon Karen , Piantedosi Bianca , Bivard Andrew , Parsons Mark William , Davis Stephen M. , Donnan Geoffrey Alan , Jannes Jim , Kleinig Timothy 
Published: June 2024

BackgroundPatients with a large vessel occlusion require a transfer from a primary stroke centre to access thrombectomy, often over significant distances in regional areas. We sought to optimise stroke care access in the regional South Australian Tele-Strokeservice (SATS) to improve patient access to thrombectomy.MethodsWe undertook a 24-month interventional historically controlled cohort study comparing acute stroke care metrics in the SATS. This consisted of a 12-month control period and a 12-month intervention monitoring period. The study intervention considered of an education package provided to the regional hospitals, a stroke neurologist roster to receive consultations and the intervention of a centralised tele-stroke system to provide treatment advice and organise patient transfers where needed. The SATS services 61 rural hospitals in South Australia, and Alice Springs in the Northern Territory. Suspected acute stroke patients presenting to the participating regional hospitals in SATS network where a telehealth consultation took place.ResultsOver the study period, there were 919 patient referrals, with 449 consultations in the pre-intervention phase and 470 in the post-intervention phase. Demographic features in both epochs were similar. The post-intervention phase was associated with shorter door-to-scan time (35 min, IQR: 18,70; vs. 49 min, IQR:25,102, p &lt; 0.0001), faster door-to-thrombolysis time (58 min, IQR: 39,91, vs.83 min, IQR: 55,100, p = 0.0324) and a higher portion of patients treated with thrombectomy (54, 11.5% vs. 26, 5.8%, p = 0.002).ConclusionAn optimised implementation of a streamlined telehealth platform with ongoing education and feedback to referring sites was associated with improved stroke workflow metrics and higher thrombectomy rates.
Emotional eating, internet overuse, and alcohol intake among college students: a pilot study with virtual reality
Authors: Marchena-Giráldez Carlos , Carbonell-Colomer Myriam , Bernabéu-Brotons Elena 
Published: June 2024

IntroductionThe term emotional eating (EE) describes the tendency to eat as an automatic response to negative emotions and has been linked to anxiety and depression, common symptoms among the university population. The EE tendencies have also been associated with excessive internet use and an increase in alcohol intake among young university students.MethodsThe aim of this study is to examine the relationship between the tendency towards EE and other health-compromising behaviors, such as excessive internet use or high alcohol intake. Additionally, it aims to investigate the association of these risky behaviors with the participants’ performance level in a virtual reality (VR) task that assesses their executive functioning, and to assess impulsivity and levels of anxiety and depression.ResultsThe results associate EE with excessive internet (r = 0.332; p &lt; 0.01). use but not with alcohol consumption. Alcohol consumption was not associated with anxiety, depression, or impulsivity, but it was related to altered executive functions in the VR task: flexibility and working memory explained 24.5% of the variance. By contrast, EE and internet overuse were not related to executive function but were associated with impulsivity, depression, and anxiety. Impulsivity and depressive symptoms accounted for 45% of the variance in EE. Depression, trait anxiety and impulsivity explained 40.6% of the variance in internet overuse.DiscussionThe results reveal distinct patterns of psychological and neuropsychological alterations associated with alcohol consumption compared to emotional eating (EE) and excessive internet use. These findings underscore significant differences in the contributing factors between addictions and other substance-free addictive behaviors. For a deeper understanding of the various contributing factors to EE in college students, further research is recommended.
Application of CT and MRI images based on artificial intelligence to predict lymph node metastases in patients with oral squamous cell carcinoma: a subgroup meta-analysis
Authors: Deng Cheng , Hu Jun , Tang Ping , Xu Tao , He Ling , Zeng Zesheng , Sheng Jianfeng 
Published: June 2024

BackgroundThe performance of artificial intelligence (AI) in the prediction of lymph node (LN) metastasis in patients with oral squamous cell carcinoma (OSCC) has not been quantitatively evaluated. The purpose of this study was to conduct a systematic review and meta-analysis of published data on the diagnostic performance of CT and MRI based on AI algorithms for predicting LN metastases in patients with OSCC.MethodsWe searched the Embase, PubMed (Medline), Web of Science, and Cochrane databases for studies on the use of AI in predicting LN metastasis in OSCC. Binary diagnostic accuracy data were extracted to obtain the outcomes of interest, namely, the area under the curve (AUC), sensitivity, and specificity, and compared the diagnostic performance of AI with that of radiologists. Subgroup analyses were performed with regard to different types of AI algorithms and imaging modalities.ResultsFourteen eligible studies were included in the meta-analysis. The AUC, sensitivity, and specificity of the AI models for the diagnosis of LN metastases were 0.92 (95% CI 0.89–0.94), 0.79 (95% CI 0.72–0.85), and 0.90 (95% CI 0.86–0.93), respectively. Promising diagnostic performance was observed in the subgroup analyses based on algorithm types [machine learning (ML) or deep learning (DL)] and imaging modalities (CT vs. MRI). The pooled diagnostic performance of AI was significantly better than that of experienced radiologists.DiscussionIn conclusion, AI based on CT and MRI imaging has good diagnostic accuracy in predicting LN metastasis in patients with OSCC and thus has the potential for clinical application.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/#recordDetails, PROSPERO (No. CRD42024506159).
Case report: Microsatellite instability determination is not always black and white in Lynch syndrome diagnosis
Authors: Rodriguez Julieta E. , Vasseur Damien , Bani Mohamed Amine , Cabaret Odile , Cotteret Sophie , Muleris Martine , Golbarg Veronica , Malka David , Pudlarz Thomas , Caron Olivier , Smolenschi Cristina 
Published: June 2024

IntroductionMicrosatellite instability (MSI) is a genetic marker that is useful in the detection and treatment of Lynch syndrome (Sd). Although conventional techniques such as immunohistochemistry (IHC) and polymerase chain reaction (PCR) are the standards for MSI detection, the advent of next-generation sequencing (NGS) has offered new possibilities, especially with circulating DNA.Case reportWe present the case of a 26-year-old patient with Lynch Sd and a BRAF-mutated metastatic colon cancer. The discordant MSI results between the conventional methods and NGS posed challenges in making treatment decisions. Subsequent NGS analysis revealed a high MSI status, leading to participation in an immunotherapy trial, with remarkable clinical response.ConclusionThis case emphasizes the importance of comprehensive molecular profiling and strong interdisciplinary collaborations, especially in cases with ambiguous MSI results.
Does the presence of blind-ended vas deferens and spermatic vessels in laparoscopic exploration of non-palpable testes conclusively indicate testicular absence?
Authors: Mao Chang-Kun , Deng Qi-Fei , Liu Xiang , Cao Yong-Sheng , Li Guang-Yuan 
Published: June 2024

ObjectiveThe purpose of this study was to determine whether the presence of blind-ended vas deferens and spermatic vessels (VDSV) during laparoscopic exploration of non-palpable testes (NPT) indicates testicular absence or atrophy.Materials and methodsA retrospective analysis was conducted on clinical data of patients diagnosed with NPT and treated with surgical intervention at our center from April 2013–April 2023. The dataset encompassed information such as the children's age, affected side, size of the contralateral testis, surgical procedures employed, outcomes, and histopathological examination results. All patients underwent physical examination and ultrasonography preoperatively, followed by a combination of laparoscopic exploration and exploration through inguinal or scrotal incisions during surgery. Long-term follow-up was conducted postoperatively.ResultsA total of 476 cases comprising 504 NPT were included in this study: 302 cases on the left side, 146 cases on the right side, and 28 cases bilaterally. All patients underwent surgical treatment within 6–126 months (median 13 months). During laparoscopic exploration, blind-ended VDSV were found in 90 testes (72 on the left side, 18 on the right side), while exploration through inguinal or scrotal incisions revealed 52 (57.8%) testicular nodules with atrophy, which were excised, leaving 38 (42.2%) without any findings. Histopathological examination of atrophic nodules revealed fibrosis as the most common finding in 41 cases (78.8%), followed by involvement of the vas deferens in 33 cases (63.5%), calcification in 24 cases (46.2%), epididymis in 23 cases (44.2%), and hemosiderin deposition in 7 cases (13.6%). Fibrosis, calcification, hemosiderin deposition, involvement of the vas deferens, and epididymis were found in combination in 47 specimens (90.4%). Seminiferous tubules (SNT) were found in 3 specimens (5.7%), and germ cells (GC) were found in 1 specimen (1.9%).ConclusionThe presence of blind-ended VDSV during laparoscopic exploration of NPT does not necessarily indicate testicular absence or disappearance. It is possible that atrophic testicular nodules are located within the inguinal canal or scrotum. This understanding contributes to the management of non-palpable testes. Considering their unpredictable malignant potential, we recommend excision.
Antimalarial and antioxidant activities of novel artesunate-ellagic acid hybrid compound in vitro and in vivo
Authors: Ishola Ahmed A. , Adebayo Joseph O. , Ceravolo Isabela P. , Tijjani Habibu , Bento Edson S. , Goulart Henrique F. , Crispim Alessandre C. , Balogun Elizabeth A. , Santana Antonio E. G. , Krettli Antoniana U. 
Published: June 2024

Introduction: Emergence of drug resistant strains of Plasmodium species has necessitated the search for novel antimalarials with unique mechanisms of action. Synthesis of hybrid compounds has been one approach to tackling this challenge. In this study, the synthesis of artesunate-ellagic acid hybrid compound (EA31) from ellagic acid and artesunate and its evaluation for antimalarial and antioxidant activities using in vitro and in vivo models were carried out.Method: EA31 was synthesized from artesunate and ellagic acid. The activities of the hybrid compound against Plasmodium falciparum W2 and P. berghei NK65 were evaluated, and its antioxidant activities were also determined.Results: The results revealed that EA31 was more active against P. falciparum W2 (chloroquine resistant) clone and less cytotoxic to buffalo green monkey kidney cell line compared to artesunate. EA31 was also active against Plasmodium berghei NK65 in vivo. The results revealed inhibition of β-hematin formation as one of the mechanisms of action of EA31. EA31 also exhibited antioxidant activities.Conclusion: The results revealed that EA31 may exert dual action of killing malaria parasite and mopping the reactive oxygen species that mediate the secondary complications of malaria.
Commercial Chinese polyherbal preparation Zao Ren An Shen prescription for primary insomnia: a systematic review with meta-analysis and trial sequential analysis
Authors: Zhao Fei-Yi , Xu Peijie , Kennedy Gerard A. , Zheng Zhen , Zhang Wen-Jing , Zhu Jia-Yi , Ho Yuen-Shan , Yue Li-Ping , Fu Qiang-Qiang , Conduit Russell 
Published: June 2024

Background: Natural products are widely used for primary insomnia (PI). This systematic review with trial sequential analysis (TSA) aimed to summarize evidence pertaining to the effectiveness and safety of Zao Ren An Shen (ZRAS) prescription, a commercial Chinese polyherbal preparation, for treating PI.Methods: Controlled clinical trials appraising ZRAS compared to controls or as an add-on treatment were systematically searched across seven databases until January 2024. Cochrane ROB 2.0 and ROBINS-I tools were adopted to determine risk of bias. Quality of evidence was assessed using the GRADE framework.Results: We analyzed 22 studies, involving 2,142 participants. The effect of ZRAS in reducing Pittsburgh Sleep Quality Index scores was found to be comparable to benzodiazepines [MD = 0.39, 95%CI (−0.12, 0.91), p = 0.13] and superior to Z-drugs [MD = −1.31, 95%CI (−2.37, −0.24), p = 0.02]. The addition of ZRAS to hypnotics more significantly reduced polysomnographically-recorded sleep onset latency [MD = −4.44 min, 95%CI (−7.98, −0.91), p = 0.01] and number of awakenings [MD = −0.89 times, 95%CI (−1.67, −0.10), p = 0.03], and increased total sleep time [MD = 40.72 min, 95%CI (25.14, 56.30), p &lt; 0.01], with fewer adverse events than hypnotics alone. TSA validated the robustness of these quantitative synthesis results. However, the quality of evidence ranged from very low to low. The limited data available for follow-up did not support meta-synthesis.Conclusion: While ZRAS prescription shows promising effectiveness in treating PI, the overall quality of evidence is limited. Rigorously-designed randomized control trials are warranted to confirm the short-term efficacy of ZRAS and explore its medium-to-long-term efficacy.Systematic Review Registration: (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=471497), identifier (CRD42023471497).
Protective factors for the risk of suffering intimate partner violence in help-seeking women survivors from a social organization in Chile
Authors: Benjumeda Wynhoven Isabel , Yago Alonso Carmen 
Published: June 2024

ObjectiveIntimate partner violence (IPV) is a major public health problem in Latin America. The present study investigates the protective factors that contribute to minimizing the risk of exposure to IPV analyzing different variables in a sample of Chilean women victims of IPV.MethodsWe used data from the Cicatrices Foundation, a nonprofit Chilean organization providing psychological support to IPV victims. Relevant variables for IPV prevention were identified analyzing a database containing all the information reported by victims during a structured interview. A final sample of 444 women suffering IPV was used in the present study.ResultsLogistic regression analysis was calculated in order to make predictions related to IPV protective factors, showing that having a support network (OR = 2.85), treatment compliance (OR = 2.05) and being younger (OR = 0.95) increased the probability of not living with the aggressor. Another logistic regression analysis was calculated in order to predict IPV victims´ health taking medication intake as an indicator. A significant association was observed between this variable and working outside (p = 0.002) and between mediation intake and age (p &lt; 0.001), with an OR of 1.987 and 0.93, respectively. Working outside and being younger were identified as protective factors against consuming medication.ConclusionTo the best of our knowledge, this is one of the first studies conducted in Chile on the prevention of IPV in a sample of victims seeking for help. Our results will contribute to guide policy makers, researchers and other women in the prevention of potential risks for IPV.
RADIO MONITORING OF TECHNOGENIC OBJECTS IN NEAR-EARTH SPACE. TECHNOLOGIES USED AND DEVELOPMENT PROSPECTS
Authors: Кизима С.В. 
Published: June 2024

Статья посвящена проблематике повышения эффективности спутникового радиомониторинга. Используемые технологии радиомониторинга не обеспечивают необходимый высокий уровень полноты спутникового радиоконтроля ввиду значительного роста количества техногенных объектов в околоземном космическом пространстве. Рассмотрены перспективные технологии спутникового радиомониторинга на основе оценки параметров состояния электромагнитной обстановки от объектов в околоземном космическом пространстве.
The article is devoted to the problems of increasing the efficiency of satellite radio monitoring. The radio monitoring technologies used do not provide the necessary high level of completeness of satellite radio monitoring due to the significant increase in the number of technical objects in near-Earth space. The article discusses promising technologies of satellite radio monitoring based on the assessment of the parameters of the state of the electromagnetic situation from objects in near-Earth space.
A MODEL OF THE PACKET SERVICE PROCESS AT IAB NODE
Authors: Мачнев Е.А. , Острикова Д.Ю. , Голос Е.С. , Гайдамака Ю.В. , Бесчастный В.А. , Кучерявый Е.А. 
Published: June 2024

Используя методы ретрансляции, технология интегрированного доступа и транспорта (Integrated Access and Backhaul, IAB), стандартизированная 3GPP, позволяет значительно сократить капитальные затраты на развертывание сетей связи 5G New Radio (NR). Данная технология может обеспечить простое и эффективное решение для предоставления бесперебойной связи на автомагистралях. Поскольку технология IAB предполагает использование ретрансляционных узлов, одним из основных показателей качества обслуживания в таких системах является задержка. В данной статье исследована средняя задержка пакета в ретрансляционном узле сети IAB. Для этого разработана модель на основе дискретной системы массового обслуживания (СМО) с одним обслуживающим прибором и тремя конечными очередями. Проведенный численный пример показал, что емкость каналов передачи в каждом из направлений является ключевым параметром для уменьшения задержки пакета.
The recently standardized by 3GPP integrated access and backhaul (IAB) technology is expected to provide costefficient densification of 5G New Radio access network. This technology may provide a simple and efficient solution for providing uninterrupted connectivity along the highways. However, relying on multi-hop communications, one of the critical metrics in such a system is latency that has been hardly explored so far. In this paper, we consider a roadside deployment of IAB system operating in millimeter wave (mmWave) band. To this aim, we utilize the tools of the queuing theory to characterize the packet delay as a function of system parameters. Our numerical results show that the choice of the transmission phases’ duration is the key optimization parameter for controlling the packet latency.
UNDERWATER WIRELESS ACOUSTIC TRANSCEIVER
Authors: Мышкин В.Ф. , Павлов И.И. , Баландин С.Ф. , Хан В.А. 
Published: June 2024

Предложена структурная схема беспроводного подводного акустического приемопередатчика, который будет характеризоваться низкой стоимостью, минимальным энергопотреблением (т.е. длительным временем автономной работы), способностью организовать связь между приемопередатчиками как в зоне прямой видимости (режим точка-точка), так и между приемопередатчиками, которые не находятся в зоне прямой видимости (транзитный режим), и модульностью (возможность замены вышедших из строя блоков, а не всего приемопередатчика).
The paper proposes a structural scheme of a wireless underwater acoustic transceiver, which will be characterized by low cost, minimal power consumption (that is, long battery life), the ability to organize communication between transceivers both in the line of sight (point-to-point mode) and to organize communication between transceivers that are not in the line of sight (transit mode) and modularity, replacing failed units rather than the entire wireless underwater acoustic transceiver.