bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of plasma and neuroimaging biomarkers to predict cognitive decline in non-demented memory clinic patients
Authors: Mendes Augusto J. , Ribaldi Federica , Lathuiliere Aurelien , Ashton Nicholas J. , Zetterberg Henrik , Abramowicz Marc , Scheffler Max , Assal Frédéric , Garibotto Valentina , Blennow Kaj , Frisoni Giovanni B. 
Published: May 2024

Abstract
Background
Plasma biomarkers of Alzheimer’s disease (AD) pathology, neurodegeneration, and neuroinflammation are ideally suited for secondary prevention programs in self-sufficient persons at-risk of dementia. Plasma biomarkers have been shown to be highly correlated with traditional imaging biomarkers. However, their comparative predictive value versus traditional AD biomarkers is still unclear in cognitively unimpaired (CU) subjects and with mild cognitive impairment (MCI).

Methods
Plasma (Aβ42/40, p-tau181, p-tau231, NfL, and GFAP) and neuroimaging (hippocampal volume, centiloid of amyloid-PET, and tau-SUVR of tau-PET) biomarkers were assessed at baseline in 218 non-demented subjects (CU = 140; MCI = 78) from the Geneva Memory Center. Global cognition (MMSE) was evaluated at baseline and at follow-ups up to 5.7 years. We used linear mixed-effects models and Cox proportional-hazards regression to assess the association between biomarkers and cognitive decline. Lastly, sample size calculations using the linear mixed-effects models were performed on subjects positive for amyloid-PET combined with tau-PET and plasma biomarker positivity.

Results
Cognitive decline was significantly predicted in MCI by baseline plasma NfL (β=-0.55), GFAP (β=-0.36), hippocampal volume (β = 0.44), centiloid (β=-0.38), and tau-SUVR (β=-0.66) (all p < 0.05). Subgroup analysis with amyloid-positive MCI participants also showed that only NfL and GFAP were the only significant predictors of cognitive decline among plasma biomarkers. Overall, NfL and tau-SUVR showed the highest prognostic values (hazard ratios of 7.3 and 5.9). Lastly, we demonstrated that adding NfL to the inclusion criteria could reduce the sample sizes of future AD clinical trials by up to one-fourth in subjects with amyloid-PET positivity or by half in subjects with amyloid-PET and tau-PET positivity.

Conclusions
Plasma NfL and GFAP predict cognitive decline in a similar manner to traditional imaging techniques in amyloid-positive MCI patients. Hence, even though they are non-specific biomarkers of AD, both can be implemented in memory clinic workups as important prognostic biomarkers. Likewise, future clinical trials might employ plasma biomarkers as additional inclusion criteria to stratify patients at higher risk of cognitive decline to reduce sample sizes and enhance effectiveness.
Development and validation of a nomogram to predict postoperative delirium in older patients after major abdominal surgery: a retrospective case-control study
Authors: Luo Yun-Gen , Wu Xiao-Dong , Song Yu-Xiang , Wang Xiao-Lin , Liu Kai , Shi Chun-Ting , Wang Zi-Lin , Ma Yu-Long , Li Hao , Liu Yan-Hong , Mi Wei-Dong , Lou Jing-Sheng , Cao Jiang-Bei 
Published: May 2024

Abstract
Background
Postoperative delirium is a common complication in older patients, with poor long-term outcomes. This study aimed to investigate risk factors and develop a predictive model for postoperative delirium in older patients after major abdominal surgery.

Methods
This study retrospectively recruited 7577 patients aged ≥ 65 years who underwent major abdominal surgery between January 2014 and December 2018 in a single hospital in Beijing, China. Patients were divided into a training cohort (n = 5303) and a validation cohort (n = 2224) for univariate and multivariate logistic regression analyses and to build a nomogram. Data were collected for 43 perioperative variables, including demographics, medical history, preoperative laboratory results, imaging, and anesthesia information.

Results
Age, chronic obstructive pulmonary disease, white blood cell count, glucose, total protein, creatinine, emergency surgery, and anesthesia time were associated with postoperative delirium in multivariate analysis. We developed a nomogram based on the above 8 variables. The nomogram achieved areas under the curve of 0.731 and 0.735 for the training and validation cohorts, respectively. The discriminatory ability of the nomogram was further assessed by dividing the cases into three risk groups (low-risk, nomogram score < 175; medium-risk, nomogram score 175~199; high-risk, nomogram score > 199; P < 0.001). Decision curve analysis revealed that the nomogram provided a good net clinical benefit.

Conclusions
We developed a nomogram that could predict postoperative delirium with high accuracy and stability in older patients after major abdominal surgery.
Moving between positions: a qualitative study of mentoring relationships in chronic eating disorders
Authors: Elran-Barak Roni , Elmalah-Alon Shiran 
Published: May 2024

Abstract
Purpose
Eating disorders (ED) are chronic and challenging-to-treat conditions, often persisting over extended periods. Some patients with EDs require prolonged intensive rehabilitation services, which may include weekly home visits by paraprofessional mentors serving as support persons, providing guidelines, emotional care, and assistance. This study aims to enhance our understanding of the nature of the relationship formed between mentors and patients with EDs.

Design & Methods
Fifteen in-depth qualitative interviews were conducted with patients and paraprofessional mentors. Interviews were analyzed using a descriptive phenomenological approach by two researchers to enhance reliability.

Findings
Qualitative analysis highlighted that mentors play a crucial role in patients’ rehabilitation. Mentors adapt two positions (investigative and embracing) to address the encountered difficulties, including conflicts, tension, and confusion associated with (in)equality and reciprocity in the mentoring relationship.

Practice Implications
Paraprofessional mentors can assist people with ED in their rehabilitation process. To support patients with EDs effectively, it is crucial to train and supervise the mentors in navigating between roles and dealing with boundaries, secrets, lies, and exposure to various aspects of the rehabilitation process. Additionally, we recommend further research using quantitative and empirical tools to complement the qualitative findings presented.
Participation, motivation, and emotional states in the course of VET teacher training: results of an 18-months longitudinal study
Authors: Bottling Matthias , Weiß Julia Katharina , Kärner Tobias 
Published: May 2024

Abstract
Background
Our study aims to investigate inter- and intraindividual effects of trainee teachers’ perceived opportunities of participation in vocational education and training teacher training on their emotional states. Additionally, it is examined whether the subjective reason for action as in intrinsic and extrinsic motivation affects the relationship between perceived participation and emotional states. In this respect, control-value theory constitutes the guiding conceptual framework in our study.

Methods
On the basis of a longitudinal design with a total of 75 trainee teachers in Germany and a maximum of 58 survey time points during 18-months of teacher training (in total 1790 individual measurements), we traced the perception of participatory opportunities, intrinsic and extrinsic motivation as well as weekly emotional states. Multilevel modeling allowed us to examine both between- as well as within-person effects of perceived participation.

Results
The results of our multilevel models indicate, among other findings, statistically significant within- and between-person effects of perceived participation opportunities on enjoyment, hope, pride, as well as anger, anxiety, shame, and hopelessness. Furthermore, the attributed subjective reason for action, i.e., the intrinsic or extrinsic motivation, moderates the relationship between perceived opportunities to participate and emotional states.

Discussion
The findings, which are consistent across different emotions of the same valence and for the two different types of motivation, indicate that those trainee teachers who report low values for intrinsic motivation (or high values for extrinsic motivation) in a given week react more responsively to changes with regard to opportunities for participatory influence.
Hyperoside mitigates photoreceptor degeneration in part by targeting cGAS and suppressing DNA-induced microglial activation
Authors: Li Daijin , Chang Jie , Wang Yujue , Du Xiaoye , Xu Jing , Cui Jingang , Zhang Teng , Chen Yu 
Published: May 2024

AbstractActivated microglia play an important role in driving photoreceptor degeneration-associated neuroinflammation in the retina. Controlling pro-inflammatory activation of microglia holds promise for mitigating the progression of photoreceptor degeneration. Our previous study has demonstrated that pre-light damage treatment of hyperoside, a naturally occurring flavonol glycoside with antioxidant and anti-inflammatory activities, prevents photooxidative stress-induced photoreceptor degeneration and neuroinflammatory responses in the retina. However, the direct impact of hyperoside on microglia-mediated neuroinflammation during photoreceptor degeneration remains unknown. Upon verifying the anti-inflammatory effects of hyperoside in LPS-stimulated BV-2 cells, our results here further demonstrated that post-light damage hyperoside treatment mitigated the loss of photoreceptors and attenuated the functional decline of the retina. Meanwhile, post-light damage hyperoside treatment lowered neuroinflammatory responses and dampened microglial activation in the illuminated retinas. With respect to microglial activation, hyperoside mitigated the pro-inflammatory responses in DNA-stimulated BV-2 cells and lowered DNA-stimulated production of 2′3′-cGAMP in BV-2 cells. Moreover, hyperoside was shown to directly interact with cGAS and suppress the enzymatic activity of cGAS in a cell-free system. In conclusion, the current study suggests for the first time that the DNA sensor cGAS is a direct target of hyperoside. Hyperoside is effective at mitigating DNA-stimulated cGAS-mediated pro-inflammatory activation of microglia, which likely contributes to the therapeutic effects of hyperoside at curtailing neuroinflammation and alleviating neuroinflammation-instigated photoreceptor degeneration.
Impacts of WWII bomb explosions on weathering damage of architectural heritage: Bath, England
Authors: Wang Xiaoyu , Mol Lisa , Tucker Maurice , Blenkinsop Tom , Gilbert Oscar , Campbell Oliver 
Published: May 2024

Abstract
The effects of bomb impacts, including the explosive force and combustion associated with these impacts, are preserved in only a few cities across the UK. In particular, World War Two (WWII) has left scars across a wide range of structures as a result of air raids. On immovable heritage, such as architectural structures, these impacts commonly take the form of craters, fractures and fire damage to stonework. This instantaneous damage is subsequently exposed to environmental stresses, such as moisture cycling, thermal stress and the movement of soluble elements and can thus lead to further deterioration of the stone. In this study, Rock Surface Hardness (RSH) measurements, permeametry measurements and microscopic observations were selected to capture stone deterioration data from 80-year-old bomb impacts on two walls of the Labour Exchange in Bath (UK) for spatial distribution analysis (Kriging) in Geographic Information Systems (GIS). The results show that the weathering forms that were found on the two walls can be attributed to nine different types. They can provide quantitative assessment of damage caused by bomb explosions and combustion in the war. The increase in permeability of walls and craters is shown to be primarily caused by the bomb explosion and combustion, whereas the decrease of hardness is associated with subsequent stone deterioration processes. This indicates that the interplay of initial damage likely accelerates subsequent response to environmental stress, extending the initial damage patterns from the impact crater to larger areas of stonework.
A case of abdominal aortic aneurysm presenting as symptomatic disseminated intravascular coagulation treated with endovascular aneurysm repair and postoperative administration of Nafamostat mesylate
Authors: Tanaka Shinichi , Ohmine Takahiro 
Published: May 2024

Abstract
Background
Cases of abdominal aortic aneurysm discovered as purpura on the extremities with disseminated intravascular coagulation (DIC) are rare. The number of currently established strategies for the control of DIC with aortic aneurysm is limited.

Case presentation
An 85-year-old woman was referred to the hematology department because of purpura on her shoulder and thigh. Enhanced fibrinolytic-type DIC was diagnosed by a blood test. Enhanced computed tomography (CT) revealed 60-mm abdominal aortic and 42-mm right common iliac aneurysms. We performed endovascular aneurysm repair (EVAR) and coiling of the right internal iliac artery with postoperative administration of Nafamostat mesylate. The patient promptly recovered from DIC, and the purpura gradually disappeared.

Conclusions
We safely performed EVAR with postoperative administration of Nafamostat mesylate for an abdominal aortic aneurysms that presented as symptomatic DIC.
Exploring sustainable forensics: silica nanoparticle powder derived from rice husk waste for aged fingermark development and the chemistry of surface interactions
Authors: Rajan Revathi , Zakaria Yusmazura , Shamsuddin Shaharum , Nik Hassan Nik Fakhuruddin 
Published: May 2024

Abstract
Background
Powder-based fingermark ridge visibility enhancement is a common technique employed in crime scenes due to ease of application and robustness of the application method. Pigmented powders created a contrast between the surfaces and developed ridgelines and are generally metals or metal oxides based. Previous research showed the successful development of fresh latent fingermarks using rice husk-derived silica nanoparticles on various surfaces. Nevertheless, there has been less previous evidence for the efficiency of the silica nanoparticle powder on aged fingermark development. Therefore, the aim here is to investigate the efficacy of the powder on aged fingermarks relative to commercial formulation to gauge the feasibility of having naturally derived powder as a possible alternative for field application and commercialisation.

Results
Rigorous testing over a range of non- and semi-porous surfaces at varied ageing conditions revealed a minimal disparity in the performance of both powders on most surfaces. Still, silica nanoparticles exhibited superiority in terms of selectivity on silica-based surfaces. Close up analysis of developed fingermarks using electron microscope exposed clear demarcation between fingermark ridges and valleys using silica nanoparticles.

Conclusions
Findings revealed that the interaction chemistry between powder particles and surface material either enhances or lowers the fingermark development capacity depending on the type of surface tested.
Cannabis and cancer: unveiling the potential of a green ally in breast, colorectal, and prostate cancer
Authors: ALSalamat Husam A. , Abuarab Sara Feras , Salamah Hazem Mohamed , Ishqair Anas Hasan , Dwikat Mohammad Fuad , Nourelden Anas Zakarya , Qandil Aseel N. , Barakat Yasmeen , Barakat Muna 
Published: May 2024

AbstractCancer comes in second place on the list of causes of death worldwide. In 2018, the 5-year prevalence of breast cancer (BC), prostate cancer (PC), and colorectal cancer (CRC) were 30%, 12.3%, and 10.9%, respectively. Cannabinoids are chemicals derived from the Cannabis sativa plant; the most investigated cannabinoids are cannabinol, delta 9-tetrahydrocannabinol (Δ9-THC), and cannabidiol. In humans, the endogenous endocannabinoid system consists of endocannabinoids, cannabinoids receptors (CBs), and enzymes that degrade the endocannabinoids. In this review, we will review the most recent literature for evidence that discusses the role of cannabis in the treatment of the three types of neoplasms mentioned. Studies have proved that BC cells express CB receptors; many in-vivo studies showed that cannabinoids cause apoptosis and inhibit proliferation and migration. Also, researchers found that treating BC mice with THC and JWH-133 (CB2 receptor agonist) slowed the tumor growth. Regarding CRC, cannabidiol was found to decrease the viability of chemotherapy-resistant CRC cells and inhibit metastasis by antagonizing the G-protein-coupled receptor 55 (GPR55; a novel cannabinoid receptor) necessary for metastasis. Moreover, cannabidiol had anti-angiogenetic effects by reducing the expression of vascular endothelial growth factor (VEGF) in addition to anti-inflammatory effects. Finally, studies demonstrated that PC cells highly express CB1 and CB2 receptors and that cannabinoids are capable of inhibiting the release of exosomes and microvesicles related to cancer progression. Cannabinoids also have antiproliferative, anti-invasive, anti-fibroblastic, cell cycle arrest, and proapoptotic effects on PC cells.
John Perceval's account of his psychosis, 1830–1832
Authors: Oyebode Femi 
Published: May 2024

SUMMARY
John Thomas Perceval (1803–1876) was confined first to Dr Fox's private madhouse (asylum) in 1830 and transferred to Mr Newington's madhouse at Ticehurst, Sussex, in 1832 until his release in 1834. His account of his incarceration and treatment was published in two versions, the first in 1838 and the second in 1840. In this article I describe Perceval's psychosis, his treatment and management at Dr Fox's madhouse and his reforming and advocating contributions to psychiatry in the period following his release.
Facing Death, Choosing Life: Pose's Positive Historiography
Authors: Washington Henry 
Published: May 2024

Abstract
From the museum heist cast members perform in its first episode to the series finale, Pose (FX, 2018–2021) endeavors to complicate the dominant historical narrative of queer and trans of color life and death at the height of the AIDS pandemic. By focalizing the vitality of the community's social life despite the disease's deathliness, the show attempts to humanize its “real” history. This article explicates the ethical dilemmas that haunt this positive historiography despite its significant value. The show's attention to the robustness of the community's social relations—particularly in its depiction of ballroom culture and the work house mothers do to make chosen families—usefully reorients viewers’ attention away from dominant historiography's pathologizing gestures. Yet simultaneously, this push for the positive threatens to obscure the structural neglect that enabled the pandemic's death toll along with the complex and often tragic reality of black and brown queer life more generally, particularly insofar as it implicitly links success to performances of homo- and transnormativity. This article tarries with rather than attempts to overcome this tension—between the structural critique and historiographic intervention modeled by the cast's theft, transport, and refashioning of the museum's historical objects and the logic of toxic positivity that takes shape in many of the show's other representations. Rather than argue for the wholesale embrace or refusal of the representational logic that inheres Pose's historiographic intervention, the article uses the show's range of historical representations as a starting point for thinking through what it means to face death and choose life amid conditions of extraordinary violence.
Foraging behaviour and habitat use during chick-rearing in the Australian endemic black-faced cormorant (Phalacrocorax fuscescens)
Authors: Cansse Thomas , Lens Luc , Sutton Grace J. , Botha Jonathan A. , Arnould John P. Y. 
Published: May 2024

ABSTRACT
Despite its wide distribution, relatively little is known of the foraging ecology and habitat use of the black-faced cormorant (Phalacrocorax fuscescens), an Australian endemic seabird. Such information is urgently required in view of the rapid oceanic warming of south-eastern Australia, the stronghold of the species. The present study used a combination of opportunistically collected regurgitates and GPS/dive behaviour data loggers to investigate diet, foraging behaviour and habitat-use of black-faced cormorants during four chick-rearing periods (2020-2023) on Notch Island, northern Bass Strait. Observed prey species were almost exclusively benthic (95%), which is consistent with the predominantly benthic diving behaviour recorded. Males foraged at deeper depths than females (median depth males: 18 m; median depth females: 8 m), presumably due to a greater physiological diving capacity derived from their larger body size. This difference in dive depths was associated with sexual segregation of foraging locations, with females predominantly frequenting shallower areas closer to the coastline. These findings have strong implications for the management of the species, as impacts of environmental change may disproportionally affect the foraging range of one sex and, thereby, reproductive success.
LONG-TERM CLINICAL RESULTS OF HALLUX VARUS CORRECTION BY A REVERSED ABDUCTOR HALLUCIS TRANSFER
Authors: Schwagten K. 
Published: May 2024

BackgroundIatrogenic hallux varus is a rare complication after hallux valgus surgery. Operative treatment comprises a wide variety of techniques, of which the reversed transfer of the abductor hallucis tendon is the most recent described technique.MethodsThis paper will present the long-term clinical results of the reversed transfer of the abductor hallucis longus. Therefore, we performed a prospective clinical observational study on 16 female patients. Our hypothesis is that the tendon transfer will persist in a good alignment and patient satisfaction on long term. There is a 100% follow-up rate with a range from 10 to 101 months. Patients were subjected to a clinical examination, three questionnaires and their general satisfaction.ResultsOut of 16 patients, at time of follow-up, we found a positive correlation between the subjective outcome score and alignment (r = 0.59), and between the general satisfaction and alignment (r = 0.77). Based on the general satisfaction we achieved a success satisfaction rate of 69% (11 patients). The other 31% (5 patients) patient group was only satisfied with major reservations or not satisfied at all. The two most invalidating complications were a coronal or sagittal malalignment or the combination of both.ConclusionOur results suggest that the reverse abductor hallucis tendon transfer is a good technique to treat a supple iatrogenic hallux varus with an observed success satisfaction rate of 69% at a mean follow-up time of 48 (range 10–101) months. However, patients should be informed that on the long-term loss of correction is possible.