bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression of Truncated Products at the 5′-Terminal Region of RIPK2 and Evolutive Aspects that Support Their Biological Importance
Authors: Villagra Ulises M M , da Cunha Bianca R , Polachini Giovana M , Henrique Tiago , Stefanini Ana Carolina Buzzo , de Castro Tialfi Bergamin , da Silva Carlos H T P , Feitosa Olavo A , Fukuyama Erica E , López Rossana V M , Dias-Neto Emmanuel , Nunes Fabio D , Severino Patricia , Tajara Eloiza H 
Published: May 2024

Abstract
Alternative splicing is the process of generating different mRNAs from the same primary transcript, which contributes to increase the transcriptome and proteome diversity. Abnormal splicing has been associated with the development of several diseases including cancer. Given that mutations and abnormal levels of the RIPK2 transcript and RIP-2 protein are frequent in tumors, and that RIP-2 modulates immune and inflammatory responses, we investigated alternative splicing events that result in partial deletions of the kinase domain at the N-terminus of RIP-2. We also investigated the structure and expression of the RIPK2 truncated variants and isoforms in different environments. In addition, we searched data throughout Supraprimates evolution that could support the biological importance of RIPK2 alternatively spliced products. We observed that human variants and isoforms were differentially regulated following temperature stress, and that the truncated transcript was more expressed than the long transcript in tumor samples. The inverse was found for the longer protein isoform. The truncated variant was also detected in chimpanzee, gorilla, hare, pika, mouse, rat, and tree shrew. The fact that the same variant has been preserved in mammals with divergence times up to 70 million years raises the hypothesis that it may have a functional significance.
Commentary on the Latest Revisions to the Detailed Rules for the Implementation of the Chinese Patent Law
Authors: Cui Guobin , Wang Xiao 
Published: May 2024

Abstract
To implement its patent law amended in 2020, China revised the Detailed Rules for the Implementation of the Chinese Patent Law on 11 December 2023. Since the revisions concern many important and controversial topics in the patent field, it is necessary to evaluate how they will impact the interests of patentees and related parties domestically and worldwide, and how China can improve its patent system to not only meet the expectations from Chinese society but also accelerate the innovation process in the world community.
To achieve that goal, this report discusses the benefits of the changes, the controversies behind them, the factors and opinions that affected the revisions, as well as the unaddressed issues and problems. Specifically, it highlights the important revisions in the principle of good faith, the request for the delayed examination, the priority system, patent term compensation, international design application, service inventions, and the open licensing system. It then briefly discusses the minor changes in the ex officio examination conducted by the patent administrative department, the patent right evaluation report, information disclosure of generic resources, and the responsibility of the patent administrative department. Meanwhile, this report points out the unsolved issues and problems in the definition of new drugs, the compensation rules for the delays caused by the marketing review of new drugs, the legislative basis of the ex officio examination conducted by the patent administrative department in the patent invalidation procedure, and the reform of the re-examination and invalidation procedures.
Health care provider movement increased through COVID-19
Authors: Luo Qian , Park Yoon Hong , Chen Candice , Petterson Stephen 
Published: May 2024

Abstract
COVID-19 placed unprecedented strain on the health workforce, raising concerns of increasing worker turnover and attrition. This study explores the use of 2 publicly available Medicare datasets—Provider Enrollment, Chain, and Ownership System (PECOS) and Doctors and Clinicians—to track provider movement across states and organizations from 2017 to 2023. We found an increase in state-to-state movement of providers post–COVID-19, with an initial spike in physician movement in the first year (April 2020 to March 2021). Movement varied across specialties and professions. Between organizations, we saw an initial increase in movement for family physicians but not internal medicine physicians. Overall, provider movement was generally to larger organizations. Our study finds increasing movement of providers in the post–COVID-19 period through the novel use of 2 publicly available Medicare datasets. Tracking health care workforce movement closer to real time is important to understand a changing workforce—with differences across communities—and to guide policies to ensure sufficient workforce and prevent worsening disparities over time.
Shifting patterns and competing explanations for infectious disease priority in global health agenda setting arenas
Authors: Smith Stephanie L , Parashar Rakesh , Nanda Sharmishtha , Shiffman Jeremy , Shroff Zubin Cyrus , Shawar Yusra Ribhi , Hamunakwadi Dereck L 
Published: May 2024

Abstract
The highly decentralized nature of global health governance presents significant challenges to conceptualizing and systematically measuring the agenda status of diseases, injuries, risks and other conditions contributing to the collective disease burden. An arenas model for global health agenda setting was recently proposed to help address these challenges. Further developing the model, this study aims to advance more robust inquiry into how and why priority levels may vary among the array of stakeholder arenas in which global health agenda setting occurs. We analyse order and the magnitude of changes in priority for eight infectious diseases in four arenas (international aid, scientific research, pharmaceutical industry and news media) over a period of more than two decades in relation to five propositions from scholarship. The diseases vary on burden and prominence in United Nations Sustainable Development Goal 3 for health and well-being, including four with specific indicators for monitoring and evaluation (HIV/AIDS, tuberculosis, malaria, hepatitis) and four without (dengue, diarrhoeal diseases, measles, meningitis). The order of priority did not consistently align with the disease burden or international development goals in any arena. Additionally, using new methods to measure the scale of annual change in resource allocations that are indicative of priority reveals volatility at the disease level in all arenas amidst broader patterns of stability. Insights around long-term patterns of priority within and among arenas are integral to strengthening analyses that aim to identify pivotal causal mechanisms, to clarify how arenas interact, and to measure the effects they produce.
A New Test Toward Consistency in International Investment Arbitration
Authors: Sun Wei 
Published: May 2024

Abstract
The issue of inconsistency in international investment arbitration has become more evident with the proliferation of investment disputes. This article analyzes the value as well as the desired extent of consistency and coherence for investment arbitration, and further proposes a new test that would enhance consistency and foster the development of investment law. By matching the current status of investment arbitration with three identified conditions for the application of stare decisis or jurisprudence constante, this article concludes that strictly applying the doctrines to achieve consistency is neither feasible nor favorable for the investment arbitration regime. Further, while the public nature of this dispute-resolution mechanism requires consistency and coherence, existing attempts and approaches in this regard have significant limitations. As such, this article proposes a soft precedents test to reach a balance between consistency and flexibility. The test requires the tribunals to consider previous cases in good faith when facing the same or similar issues discussed therein, and the core consideration in whether to agree with previous cases is to develop international investment law. It is suggested that this proposed test would help to clarify, enrich and develop the content of the law within the investment arbitration community.
Complete surgical repair for enlarging coronary aneurysm with coronary-pulmonary artery fistula
Authors: Kobayashi Masaaki , Kuroyanagi Satoshi , Furuya Onichi , Matsuura Makoto 
Published: May 2024

Abstract
A 46-year-old male patient was referred to our hospital due to the presence of a coronary aneurysm showing a tendency to enlarge. Subsequent coronary angiography revealed a diagnosis of coronary aneurysm with a concomitant coronary-pulmonary artery fistula. The patient underwent a successful surgical repair, and postoperatively, experienced an uneventful recovery with no residual shunt or aneurysm.
A Systematic Review of Simulation in Burn Care: Education, Assessment, and Management
Authors: Moshal Tayla , O’Brien Devon , Roohani Idean , Jimenez Christian , Kondra Katelyn , Collier Zachary J , Carey Joseph N , Yenikomshian Haig A , Gillenwater Justin 
Published: May 2024

Abstract
Assessment and management of burns require nuanced, timely interventions in high-stake settings, creating challenges for trainees. Simulation-based education has become increasingly popular in surgical and nonsurgical subspecialties to supplement training without compromising patient safety. This study aimed to systematically review the literature on existing burn management-related simulations. A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Articles describing burn-specific surgical and nonsurgical simulation models were included. The model type, study description, simulated skills, assessment methods, fidelity, cost, and outcomes were collected. Of 3472 articles, 31 met the inclusion criteria. The majority of simulations were high-fidelity (n = 17, 54.8%). Most were immersive (n = 17, 54.8%) and used synthetic benchtop models (n = 13, 41.9%), whereas none were augmented reality (AR)/virtual reality (VR). Simulations of acute and early surgical intervention techniques (n = 16, 51.6%) and burn wound assessments (n = 15, 48.4%) were the most common, whereas burn reconstruction was the least common (n = 3, 9.7%). Technical skills were taught more often (n = 29, 93.5%) than nontechnical skills (n = 15, 48.4%). Subjective assessments (n = 18, 58.1%) were used more often than objective assessments (n = 23, 74.2%). Of the studies that reported costs, 91.7% (n = 11) reported low costs. This review identified the need to expand burn simulator options, especially for burn reconstruction, and highlighted the paucity of animal, cadavers, and AR/VR models. Developing validated, accessible burn simulations to supplement training may improve education, patient safety, and outcomes.
After 50 Years, It Is Time to Talk about Value Hierarchy and Inequality
Authors: Trujillo-Torres Lez E , DeBerry-Spence Benét , Grier Sonya A , Askegaard Søren 
Published: May 2024

Abstract
This research enriches the field’s perspective on value and argues that to seriously address inequality during the next 50 years, consumer research must explore processual aspects of value hierarchy and consider its relationship to inequality. Doing so recognizes the duality of structures as embodying outcomes and agency, as well as the need to view value not only as what it is but also as what it does. To begin to address limitations in the literature, we use empirical evidence from an investigation of the cancer care market from 1970 to 2021 to understand how value hierarchy shapes and manifests as inequality. This is conceptualized as: distribution of multilevel resources, consolidation of consumer power, stratification of consumer agency, and (de)credentialization of worthiness. Building on each of these, we discuss a research agenda for future JCR inquiries and introduce “value hierarchy as inequality” as a big-tent issue for consumer research.
Beyond Scarcity: A Social Value-Based Lens for NFT Pricing
Authors: Hofstetter Reto , Fritze Martin P , Lamberton Cait 
Published: May 2024

Abstract
Over the last half-century, consumer research has often depicted scarcity as a dominant factor increasing price. But should we assume that scarcity’s upward pressure on price remains intact, in a world where novel forms of digital products proliferate? In this article, we propose that blockchain-encrypted digital goods, in particular, non-fungible tokens (NFTs), offer good reason to revisit this assumption. In this context, we argue and find that social value can outweigh intrinsic value as a determinant of willingness-to-pay. As a result, when scarcity threatens access to high levels of social value, its effect on price can be negative rather than positive—an inversion of a pattern typically observed for offline collectibles. Secondary data taken from the NFT platform Opensea and a set of experimental studies support this social value-based lens. Given these findings, we propose a research agenda to ground future work in this area. We also suggest that NFTs offer a laboratory in which past theories related to social value, scarcity, and price can be reconsidered and future theories developed, hopefully allowing consumer researchers to lead knowledge development in these domains over the next 50 years.
A robot-based surveillance system for recognising distress hand signal
Authors: Riego del Castillo Virginia , Sánchez-González Lidia , González-Santamarta Miguel Á , Rodríguez Lera Francisco J 
Published: May 2024

Abstract
Unfortunately, there are still cases of domestic violence or situations where it is necessary to call for help without arousing the suspicion of the aggressor. In these situations, the help signal devised by the Canadian Women’s Foundation has proven to be effective in reporting a risky situation. By displaying a sequence of hand signals, it is possible to report that help is needed. This work presents a vision-based system that detects this sequence and implements it in a social robot, so that it can automatically identify unwanted situations and alert the authorities. The gesture recognition pipeline presented in this work is integrated into a cognitive architecture used to generate behaviours in robots. In this way, the robot interacts with humans and is able to detect if a person is calling for help. In that case, the robot will act accordingly without alerting the aggressor. The proposed vision system uses the MediaPipe library to detect people in an image and locate the hands, from which it extracts a set of hand landmarks that identify which gesture is being made. By analysing the sequence of detected gestures, it can identify whether a person is performing the distress hand signal with an accuracy of 96.43%.
The Network Factor of Equity Pricing: A Signed Graph Laplacian Approach
Authors: Uddin Ajim , Tao Xinyuan , Yu Dantong 
Published: May 2024

Abstract
The connections among firms exhibit heterogeneity, complexity, and dynamism, posing a challenge for traditional unsigned network models. This article proposes a signed graph Laplacian approach to construct a dynamic network index (DNI), quantifying the aggregate changes in the market network over time. A larger DNI indicates more significant changes in firms’ interconnectedness and in the market network structure. Firms with higher sensitivity to DNI exhibit lower expected returns. Incorporating DNI into conventional asset pricing models improves return predictability. Results are robust for multiple estimators, various factor models, and different selections of test assets. Our findings suggest that the network factor generates a significant equity risk premium.
The binding of cosmological structures by massless topological defects
Authors: Lieu Richard 
Published: May 2024

ABSTRACT
Assuming spherical symmetry and weak field, it is shown that if one solves the Poisson equation or the Einstein field equations sourced by a topological defect, i.e. a singularity of a very specific form, the result is a localized gravitational field capable of driving flat rotation (i.e. Keplerian circular orbits at a constant speed for all radii) of test masses on a thin spherical shell without any underlying mass. Moreover, a large-scale structure which exploits this solution by assembling concentrically a number of such topological defects can establish a flat stellar or galactic rotation curve, and can also deflect light in the same manner as an equipotential (isothermal) sphere. Thus, the need for dark matter or modified gravity theory is mitigated, at least in part.
A native species contributes to biotic homogeneity of urban land snails in Thailand
Authors: Bergey Elizabeth A , Dumrongrojwattana Pongrat , Boonmachai Tuangthong , Nantarat Nattawadee 
Published: May 2024

ABSTRACT
Biotic homogenization or the increasing similarity of biota has been documented in urban land snail assemblages in Europe and North America. The resulting biotic homogeneity is caused by a loss of native species and the establishment of non-native species. Climate affects land snail distributions, and because Thailand (exclusive of the southern peninsula) has an almost uniform climate, we hypothesized that urban land snail populations would show a high degree of taxonomic homogeneity. We sampled 76 sites (e.g. yards, temple grounds, restaurants and hotels) over a 38-day period during the rainy season in 2022. These sites included three regions: central (five provinces), north (two provinces) and northeast (five provinces). Both live snails and shells were counted, and the 10,470 counted individuals represented 25 taxa. Biotic homogeneity was indicated by three taxa comprising 69.9% of individuals. By far the most abundant species was the native species Sarika siamensis, which was found at all 76 sites and comprised 50.4% of all individuals. The other two abundant species were non-native species—the giant African snail Lissachatina fulica (60 sites) and Allopeas gracile (50 sites)—both widespread synanthropic species. Three other non-native species were also found. Among native species, slugs, including semislugs, were widespread but occurred in low numbers, and Pupina sp. occurred in high abundance (mean = 97 individuals/site) at 13 highly watered locations within its native range. Urban snail assemblages were not entirely homogeneous, as assemblages in the north region differed from those in the central and northeast regions. In conclusion, urban snail assemblages in Thailand showed a high degree of biotic homogeneity, in large part due to a native species, S. siamensis, indicating that native synanthropic species can contribute to biotic homogeneity.
Long-term clinical course of two rare cases of synovitis-acne-pustulosis-hyperostosis-osteomyelitis syndrome involving only unilateral femur
Authors: Ito Hiroki , Hirano Yuji 
Published: May 2024

ABSTRACT
Synovitis-acne-pustulosis-hyperostosis-osteomyelitis (SAPHO) syndrome is characterised by aseptic osteitis and is often complicated by pustular dermatitis, such as palmoplantar pustulosis or acne. Although bone lesions are most found in the anterior thoracic region or spine, femoral lesions are not well documented in the literature. There is no established treatment for this condition, and few reports have described its long-term course. Here, we describe two cases of SAPHO syndrome involving the femur and discuss their long-term follow-up. A 40-year-old man (Case 1) presented with right thigh pain. Fifteen years after the initial diagnosis, the pain could be controlled with minomycin, salazosulfapyridine, and methotrexate. X-rays of the femur showed gradual cortical thickening. Although there were waves of pain, it gradually improved with the adjustment of drugs 25 years following the initial diagnosis. A 35-year-old man (Case 2) with right thigh pain was prescribed salazosulfapyridine and methotrexate; however, these were ineffective. Alendronate and guselkumab also proved ineffective. Ultimately, infliximab was started 9 years following disease onset, and pain became manageable. X-rays of the femur showed cortical thickening. SAPHO syndrome can be managed with drug therapies, such as nonsteroidal anti-inflammatory drugs, methotrexate, and conventional synthetic disease-modifying antirheumatic drugs; however, there are occasional treatment-resistant cases.
Deep learning for the PSIPRED Protein Analysis Workbench
Authors: Buchan Daniel W A , Moffat Lewis , Lau Andy , Kandathil Shaun M , Jones David T 
Published: May 2024

Abstract
The PSIRED Workbench is a long established and popular bioinformatics web service offering a wide range of machine learning based analyses for characterizing protein structure and function. In this paper we provide an update of the recent additions and developments to the webserver, with a focus on new Deep Learning based methods. We briefly discuss some trends in server usage since the publication of AlphaFold2 and we give an overview of some upcoming developments for the service. The PSIPRED Workbench is available at http://bioinf.cs.ucl.ac.uk/psipred.
A-MYB substitutes for B-MYB in activating cell cycle genes and in stimulating proliferation
Authors: Kohler Robin , Engeland Kurt 
Published: May 2024

Abstract
A-MYB (MYBL1) is a transcription factor with a role in meiosis in spermatocytes. The related B-MYB protein is a key oncogene and a master regulator activating late cell cycle genes. To activate genes, B-MYB forms a complex with MuvB and is recruited indirectly to cell cycle genes homology region (CHR) promoter sites of target genes. Activation through the B-MYB-MuvB (MMB) complex is essential for successful mitosis. Here, we discover that A-MYB has a function in transcriptional regulation of the mitotic cell cycle and can substitute for B-MYB. Knockdown experiments in cells not related to spermatogenesis show that B-MYB loss alone merely delays cell cycle progression. Only dual knockdown of B-MYB and A-MYB causes G2/M cell cycle arrest, endoreduplication, and apoptosis. A-MYB can substitute for B-MYB in binding to MuvB. The resulting A-MYB-MuvB complex activates genes through CHR sites. We find that A-MYB activates the same target genes as B-MYB. Many of the corresponding proteins are central regulators of the cell division cycle. In summary, we demonstrate that A-MYB is an activator of the mitotic cell cycle by activating late cell cycle genes.
Genome editing outcomes reveal mycobacterial NucS participates in a short-patch repair of DNA mismatches
Authors: Islam Tanjina , Josephs Eric A 
Published: May 2024

Abstract
In the canonical DNA mismatch repair (MMR) mechanism in bacteria, if a nucleotide is incorrectly mis-paired with the template strand during replication, the resulting repair of this mis-pair can result in the degradation and re-synthesis of hundreds or thousands of nucleotides on the newly-replicated strand (long-patch repair). While mycobacteria, which include important pathogens such as Mycobacterium tuberculosis, lack the otherwise highly-conserved enzymes required for the canonical MMR reaction, it was found that disruption of a mycobacterial mismatch-sensitive endonuclease NucS results in a hyper-mutative phenotype, leading to the idea that NucS might be involved in a cryptic, independently-evolved DNA MMR mechanism, perhaps mediated by homologous recombination (HR) with a sister chromatid. Using oligonucleotide recombination, which allows us to introduce mismatches specifically into the genomes of a model for M. tuberculosis, Mycobacterium smegmatis, we find that NucS participates in a direct repair of DNA mismatches where the patch of excised nucleotides is largely confined to within ∼5–6 bp of the mis-paired nucleotides, which is inconsistent with mechanistic models of canonical mycobacterial HR or other double-strand break (DSB) repair reactions. The results presented provide evidence of a novel NucS-associated mycobacterial MMR mechanism occurring in vivo to regulate genetic mutations in mycobacteria.