bluuebunny/crossref_metadata_2025_split huggingface dataset:
Finding a mix of renewable energy for different stakeholders by applying multi‐criteria decision‐making techniques
Authors: Bilbao‐Terol Amelia , Cañal‐Fernández Verónica , González‐Pérez Carmen 
Published: February 2025

AbstractThis paper presents a two‐stage model for planning a renewable energy portfolio by balancing economic, social and environmental sustainability goals. The first stage addresses a multi‐objective problem where conflictive impacts generated by the energy portfolios should be optimised according to the corresponding economic, social or environmental profile. A parametric goal programming with a fuzzy hierarchy model, an alternative to the weighted and lexicographic goal programming models, is built. The second stage, comprising three steps, identifies the best energy mix for each profile. First, preferential weights are determined economically and flexibly by the decision‐maker (DM) using the extended best‐worst method. Then, a valuation process is applied to each portfolio's deviation vectors, and the transformed deviation vectors are ranked using the technique for order preference by similarity to ideal solution (TOPSIS) method. Applied to Spain, the results reveal significant conflict in the social profile, especially regarding total employment, which shows the greatest disagreement with other impacts. In contrast, the economic and environmental profiles exhibit low divergence among their key impacts. This work suggests that policymaking in renewable energy requires a balanced approach and, sometimes, the acceptance of unavoidable trade‐offs between objectives. Our proposal guides the search for energy portfolios with strong DM intervention.
‘What Matters, Doctor?’ A Qualitative and Inclusive Study of the Experience of Mainstream Healthcare Among People With Intellectual Disabilities in Belgium
Authors: Miceli A. , Lucassen L. , Rinaldi R. , Van Ooteghem N. , Walter D. , Perau M. , Kahwaji C. , Mayart A. , Batselé E. 
Published: February 2025

ABSTRACTBackgroundThis study investigates the healthcare needs and experiences of adults with intellectual disabilities, focusing on identifying areas for improvement. Its innovation lies in including individuals with intellectual disabilities as co‐researchers in the research process.MethodThematic analysis was performed on five focus groups with 30 participants, exploring access to healthcare. Three co‐researchers played active roles in reviewing the interview, recruitment, facilitation and co‐analysis of results.ResultsThree types of specific needs emerged: communication, relational and support needs, as well as challenges in empowerment and shortcomings in the skills of professionals.ConclusionsIntervention programmes aimed at training doctors and healthcare professionals should consider the specific difficulties and needs of people with intellectual disability, and their input should be prioritised in the design of these interventions.
Bu Yang Huan Wu Prevents Osteogenic Effect of Muscle‐Derived Stromal Cells via Regulating JAK/STAT Pathway
Authors: Cao Guorui , Zhang Shaoyun , Liao Yuanping , Yue Chen , Yang Lanbo , Guo Jiayi , Tong Peijian , Tan Honglue 
Published: February 2025

ABSTRACTHeterotopic ossification (HO) is a crucial pathological process in which bone or calcification develop in skeletal muscle and surrounding soft tissues. Muscle‐derived stromal cells (MDSC) are important muscle‐resident mesenchymal progenitor cells and macrophage‐derived oncostatin M (OSM) can induce osteogenic differentiation. Bu Yang Huan Wu (BYHW), which has a long history of use in restraining inflammation, can prevent osteogenic differentiation and HO formation while underlying mechanism is still unclear. The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signalling pathway is an important pathway to regulate osteogenic differentiation of related cells. In this study, we investigated whether BYHW could inhibit osteogenesis effect of MDSC through OSM mediated by macrophages, and whether JAK/STAT pathway regulated this biological process. We found that activated macrophages promoted osteogenic differentiation of MDSC through OSM and BYHW could decrease the level of OSM and osteogenic activity of MDSC. Further, we confirmed the regulatory effect of JAK/STAT pathway, blocking this pathway could suppress the level of OSM and osteogenic differentiation of MDSC. We showed that BYHW could suppress osteogenic differentiation of MDSC through JAK/STAT signalling. These findings expand the application scope of traditional Chinese medicine and provide a basis for the further investigation of the potential therapeutic role of HO.
A Scoping Review of the Ways Gatekeepers May Hinder or Promote Opportunities for People With Intellectual and/or Developmental Disabilities to Learn About Research Participation
Authors: Brodeur Madison , Schwartz Ariel , McDonald Katherine 
Published: February 2025

ABSTRACTBackgroundAdults with intellectual and/or developmental disabilities are disproportionately excluded from participation in research, consequently increasing disparities experienced by this group. Gatekeepers, individuals who control access to research participation opportunities, may either support or pose a barrier to inclusion in research. We sought to understand how gatekeepers serve as supports and barriers to the participation of people with intellectual and/or developmental disabilities in research and the factors that may drive their actions. We also sought to identify approaches to interacting with gatekeepers that promoted the sharing of research participation opportunities.MethodsWe conducted a scoping review of manuscripts published between January 2009 and September 2024 describing gatekeeping during recruitment for adults with intellectual and/or developmental disabilities in social/behavioural research. We conducted content analysis of 22 manuscripts to identify ‘gate opening’ actions (actions that support research participation) and ‘gate closing’ actions (actions that pose a barrier to research participation) at the point of recruitment. We also identified approaches researchers took when interacting with gatekeepers to promote gate opening actions.ResultsGatekeepers' attitudes (e.g., valuing research) and knowledge about prospective participants were associated with gate opening actions. Gatekeepers' attitudes of mistrust of researchers and/or research, deprioritisation of research and presumed incapacity of people with intellectual and/or developmental disabilities to consent to, participate in and/or benefit from research participation were associated with gate closing actions. Gatekeepers' lack of information (e.g., about research and prospective participants) was also associated with gate closing actions. Restrictive organisational policies and gatekeepers' lack of resources (e.g., time) were also associated with gate closing actions. Approaches for interacting with gatekeepers that may foster gate opening actions included: addressing gatekeeper concerns, educating gatekeepers about the benefits of research participation and developing relationships with gatekeepers.ConclusionWe identified several malleable factors that may drive gate opening and gate closing actions. Enhanced collaboration between researchers and gatekeepers may foster greater opportunities for individuals with intellectual and/or developmental disabilities to learn about research opportunities.
Consumers' Sensory Profile and Understanding of Clean‐Label Sausage. An Approach Using Ultra‐Flash Profile and Check‐All‐That‐Apply
Authors: Sbardelotto Paula Rabelo , da Trindade Alfaro Alexandre , Teixeira Alfredo , Mitterer‐Daltoé Marina Leite 
Published: February 2025

ABSTRACTClean‐label meat products are trending in the food industry; however, they are little known by consumers. In this context, the present work aims to: (i) assess the sensory characteristics of fresh sausage supplemented with natural additives through the application of ultra‐flash profile (UFP) and (ii) investigate consumers' knowledge of clean‐label meat products using check‐all‐that‐apply (CATA) questions. Fresh sausage formulations were prepared from different concentrations of celery and rosemary extracts with curry. The results showed that different concentrations of these natural additives corresponded to different sensory profiles. The attributes that most effectively distinguish sausages are their red color, flavorful seasoning, juiciness, and spiciness. The results from CATA questions indicate a lack of understanding regarding chemicals and additives in food, as well as about clean‐label. Clean‐label meat sausage appears promising as consumers place a high value on natural additives. The remaining challenge for the meat industry's marketing sector is to establish a connection between natural additives and clean‐label products in the minds of consumers.
Recent Advances in Diagnostics and Therapeutics for Paediatric Thyroid Cancer
Authors: Vanderniet Joel A. , Fuentes‐Bolanos Noemi A. , Cho Yoon Hi , Chung David K. V. , Sandler Gideon , Moghimi Ali , Padhye Bhavna , Tucker Kathy , Anazodo Antoinette , Benitez‐Aguirre Paul Z. 
Published: February 2025

ABSTRACTPurpose of ReviewPaediatric thyroid cancer management traditionally relied on extrapolation from adult data and, despite good survival outcomes, often involved extensive surgical approaches and radioactive iodine (RAI) therapy with potentially life‐long complications. Increasing understanding of paediatric diagnostic techniques, molecular tumour drivers and targeted therapies will allow a more nuanced, disease‐specific comprehensive model of care. This review summarises recent developments in paediatric thyroid cancer biology, diagnosis and models of care.MethodsReview of relevant literature from the last 5 years to inform a narrative summary by a multidisciplinary team of clinician experts in paediatric thyroid cancer management.FindingsStandardised risk scoring systems will likely improve the objectivity and accuracy of paediatric thyroid nodule risk stratification on ultrasound, but further studies are needed to validate these. Identification of somatic and germline gene variants is playing a rapidly increasing role in paediatric thyroid cancer diagnosis and planning of surgical approaches and neoadjuvant and adjuvant therapies. There is growing recognition that lobectomy may achieve comparable outcomes, with reduced risk of complications, to total thyroidectomy in patients with low‐risk disease. Molecularly targeted therapies are now available for the management of advanced disease as an adjuvant, and likely neo‐adjuvant, therapy for medical debulking of large tumours and resensitisation of RAI‐resistant disease.ConclusionsThe management pathways for paediatric thyroid cancer are rapidly evolving due to the increasing availability of paediatric‐specific data. As management options become more complex, interdisciplinary collaboration and shared decision‐making are ever more important.
Topical Steroid Withdrawal: An Emerging Challenge in the Treatment of Atopic Dermatitis
Authors: Larney Conor , Courtney Ashling , Yazdabadi Anousha , Su John C. 
Published: February 2025

ABSTRACTTopical corticosteroids (TCS) have been a cornerstone in managing atopic dermatitis (AD) since their introduction in 1952. Though there are well‐documented adverse effects attributed to their use, the existence of some complications of TCS use, including topical steroid withdrawal (TSW) syndrome, characterised by TCS dependence and skin disease worsening after TCS discontinuation, are more controversial within the dermatology community. There is no consensus on diagnostic criteria for TSW or clarity on its prevalence, natural history and management. Media reports are common and TSW overdiagnosis may lead to steroid phobia, poor adherence to TCS therapy, and unnecessary, increased, and protracted AD flares. This paper reviews the historical context, clinical presentations, challenges in diagnosis and the ongoing debate regarding TSW, with a focus on the implications for patient management and the potential consequences of steroid phobia on treatment adherence.
New developments in insomnia assessment and diagnosis: Self‐reported questionnaires, clinical interviews, and ecological momentary assessment
Authors: Cerolini Silvia , Ellis Jason G. , Meneo Debora , Baldi Elisabetta , Baglioni Chiara 
Published: February 2025

SummaryAccurate and timely assessment is essential for diagnostic and therapeutic purposes. Over the past few years, new developments in the assessment of insomnia disorder have been outlined. This review aims to summarise the available instruments in line with the updated scientific research and advances in clinical sleep research. A synthesis of new developments in the field from 2020 to 2024, focussing on self‐reported questionnaires, clinical interviews, and ecological momentary assessment, are provided. After exploring novel advances and their interplay with evidence‐based validated instruments, we will discuss limitations and future directions. What are we missing? What should be improved and ameliorated? What are the next steps for insomnia assessment and diagnosis regarding methodology, dissemination, and practice?
The Magnaporthe oryzae effector MoBys1 suppresses rice immunity by targeting OsCAD2 to manipulate host jasmonate and lignin metabolism
Authors: Liu Chengyu , Han Li‐Bo , Wen Yanhong , Lu Chuner , Deng Boqian , Liu Zixuan , Deng Xianya , Shen Ningning , Tang Dingzhong , Li Yuan‐Bao 
Published: February 2025

Summary
Rice blast disease caused by Magnaporthe oryzae poses a severe threat to rice production. To counteract M. oryzae, plants synthesize jasmonate (JA) and lignin, two primary defense‐related metabolites, to initiate defense programs. However, the mechanism through which M. oryzae modulates JA‐ and lignin‐mediated plant immunity remains unclear.
In this study, a novel M. oryzae effector, MoBys1, was identified as being involved in pathogenesis. Knockout of MoBys1 in M. oryzae significantly reduced its infection ability. Conversely, overexpression of MoBys1 in rice impaired the rice defense response. MoBys1 localizes to the plant cytoplasm and nucleus and interacts with rice cinnamyl alcohol dehydrogenase 2 (OsCAD2), an enzyme that catalyzes lignin biosynthesis. While OsCAD2 mutants exhibited weakened defenses, overexpression lines demonstrated enhanced resistance, highlighting the critical role of OsCAD2 in blast resistance.
Furthermore, OsCAD2 functions as a transcription factor regulating a wide range of biological processes, including JA and lignin signaling pathways. The interaction between MoBys1 and OsCAD2 promotes OsCAD2 degradation, leading to reduced lignin and JA accumulation.
These findings uncover a novel counter‐defense mechanism by which M. oryzae employs the effector MoBys1 to degrade OsCAD2 and suppress host defense‐related metabolite accumulation during infection.
Nonadditive regulation confers phenotypic variation in hybrid maize
Authors: Zhou Tao , Zhang Jie , Liang Yan , Gu Riliang , Ma Yuting , Zhu Wanchao , Li Juan , Du Xuemei , Wang Xiaoli , Wang Pingxi , Liu Yangyang , Zhen Sihan , Fu Junjie , Li Lin , Zhang Hongwei 
Published: February 2025

Summary
Our knowledge of how the parental genomes interact to shape hybrid performance remains limited.
This work established four hybrid maize populations and evaluated plant height (PH) in both the parental and hybrid populations, generating an extensive transcriptome and translatome dataset. We conducted a genome‐wide association study, expression quantitative trait locus (eQTLs) mapping, transcriptome‐wide association mapping (TWAS), and allele‐specific expression analysis to elucidate the regulatory mechanisms underlying PH variation in hybrids.
QTLs, eQTLs, and TWAS‐associated genes (TAGs) exhibited both distinct variations and conserved patterns between the maternal and hybrid populations. The functional route (FR)‐following QTLs demonstrated significant nonadditive effects on PH and expression traits. The intergenomic interactions of eQTLs in the heterozygous state drive the nonadditive regulation of eQTL‐regulated genes (eGenes), resulting in the transformation of eGenes into TAGs and eQTLs into nonadditive QTLs for PH. This regulatory mechanism is further supported by the nonadditive regulation of phytohormone‐related genes. Additionally, nonadditive TAGs and QTLs are implicated in regulating nonadditive translation.
This study elucidates how nonadditive QTLs contribute to phenotypic variation in hybrid maize, offering a fresh perspective on the understanding of plant heterosis.
Is It Going Above and Beyond or Breaking the Rules? How Clients' Identities, Perceived Deservingness, and Outcomes Affect Citizens' Judgments of Bureaucrats' Rule Decisions
Authors: Wolff Johnathan Noah 
Published: February 2025

ABSTRACTIn this paper, I explore factors that shape citizens' agreement with street‐level bureaucrats' decisions to either follow agency rules or break them for the explicit purpose of benefitting their clients (i.e., pro‐social rule breaking). I use data collected via an original survey experiment (n = 3485) to assess the relative effects of information about a street‐level bureaucrat's compliance with agency rules and the outcome their client experienced, asking whether the ends (e.g., a positive client outcome) ever justify the means (e.g., a bureaucrat choosing to pro‐socially break agency rules to help a client) for citizens. I also go a step further, assessing relative effects of information about the client's identity (i.e., race and gender) and deservingness to ask whether questions of for whom street‐level bureaucrats follow/pro‐socially break agency rules influence citizens' agreement. I find that citizens expressed significantly more average agreement with bureaucrats' decisions to follow rules rather than pro‐socially break them, and that citizens expressed more agreement with pro‐social rule‐breaking decisions when clients experienced positive outcomes. While cues about the client's race, gender, and deservingness initially seemed insignificant, a closer examination showed that citizens' agreement with bureaucrats' rule decisions sometimes depended on the race and gender of the client for whom those decisions were made. Overall, results indicate that some citizens base their agreement with a bureaucrat's rule decision on not only the bureaucrat's compliance and the client's outcome but also on whom the bureaucrat is serving.
Harnessing haploid‐inducer mediated genome editing for accelerated maize variety development
Authors: Li Lina , Fu Xiao , Qi Xiantao , Xiao Bing , Liu Changling , Wu Qingyu , Zhu Jinjie , Xie Chuanxiao 
Published: February 2025

SummaryThe integration of haploid induction and genome editing, termed HI‐Edit/IMGE, is a promising tool for generating targeted mutations for crop breeding. However, the technical components and stacking suitable for the maize seed industry have yet to be fully characterised and tested. Here, we developed and assessed three HI‐Edit/IMGE maize lines: EditWx, EditSh, and EditWx&Sh, using the haploid inducer CHOI3 and lines engineered using the CRISPR‐Cas9 system targeting the Waxy1 (Wx1) and Shrunken2 (Sh2) genes. We meticulously characterised the HI‐Edit/IMGE systems, focusing on copy numbers and the mutant alleles mtl and dmp, which facilitate haploid induction. Using B73 and six other parental lines of major commercial varieties as recipients, HI‐Edit/IMGE demonstrated maternal haploid induction efficiencies ranging from 8.55% to 20.89% and targeted mutation rates between 0.38% and 1.46%. Comprehensive assessment verified the haploid identification, target gene editing accuracy, genome background integrity, and related agronomic traits. Notably, EditWx&Sh successfully combined distinct CRISPR‐Cas9 systems to induce multiple desired mutations, highlighting the potential of HI‐Edit/IMGE in accelerating the integration of edited traits into commercial maize varieties. Our findings underscore the importance of meticulous Cas9 copy number characterisation and highlight potential challenges related to somatic chimerism. We also validated the performance of single‐cross haploids derived using the HI‐Edit/IMGE process. Our results confirm the industrial applicability of generating targeted mutations through pollination and provide critical insights for further optimising this technology.
A High‐Throughput Phenotyping Pipeline for Quinoa (Chenopodium quinoa) Panicles Using Image Analysis With Convolutional Neural Networks
Authors: Lozano‐Isla Flavio , Kienbaum Lydia , Haussmann Bettina I. G. , Schmid Karl 
Published: February 2025

ABSTRACTQuinoa is a grain crop with excellent nutritional properties that has attracted global attention for its potential contribution to future food security in a changing climate. Despite its long history of cultivation, quinoa has been improved little by modern breeding and is a niche crop outside its native cultivation area. Grain yield is strongly affected by panicle traits, whose phenotypic analysis is time consuming and prone to error because of their complex architecture, and automated image analysis is an efficient alternative. We designed a panicle phenotyping pipeline implemented in Python via mask R‐convolutional neural networks for panicle segmentation and classification. After model training, we analysed 5151 images of quinoa panicles collected over three consecutive seasons from a breeding programme in the Peruvian highlands. The pipeline follows a stagewise approach, which first selects the optimal segmentation model and then another model that best classifies panicle shape. The best segmentation model achieved a mean average precision (mAP) score of 83.16 and successfully extracted the panicle length, width, area and RGB values. The classification model achieved 95% prediction accuracy for the amarantiform and glomerulate panicle types. A comparison with manual trait measurements using ImageJ revealed a high correlation for panicle traits (r > 0.94, p < 0.001). We used the pipeline with images from multilocation trials to estimate genetic variance components of an index on the basis of panicle length and width. We further updated the model for images that included metric scales taken in field trials to extract metric measurements of panicle traits. Our pipeline enables accurate and cost‐effective phenotyping of quinoa panicles. Using automated phenotyping based on deep learning, optimal panicle ideotypes can be selected in quinoa breeding and improve the competitiveness of this underutilized crop.