bluuebunny/crossref_metadata_2025_split huggingface dataset:
Large-Scale Alternative Polyadenylation-Wide Association Studies to Identify Putative Cancer Susceptibility Genes
Authors: Guo Xingyi , Ping Jie , Yang Yaohua , Su Xinwan , Shu Xiao-Ou , Wen Wanqing , Chen Zhishan , Zhang Yunjing , Tao Ran , Jia Guochong , He Jingni , Cai Qiuyin , Zhang Qingrun , Giles Graham G. , Pearlman Rachel , Rennert Gad , Vodicka Pavel , Phipps Amanda , Gruber Stephen B. , Casey Graham , Peters Ulrike , Long Jirong , Lin Weiqiang , Zheng Wei 
Published: May 2024

Abstract
Alternative polyadenylation (APA) modulates mRNA processing in the 3′-untranslated regions (3′ UTR), affecting mRNA stability and translation efficiency. Research into genetically regulated APA has the potential to provide insights into cancer risk. In this study, we conducted large APA-wide association studies to investigate associations between APA levels and cancer risk. Genetic models were built to predict APA levels in multiple tissues using genotype and RNA sequencing data from 1,337 samples from the Genotype-Tissue Expression project. Associations of genetically predicted APA levels with cancer risk were assessed by applying the prediction models to data from large genome-wide association studies of six common cancers among European ancestry populations: breast, ovarian, prostate, colorectal, lung, and pancreatic cancers. A total of 58 risk genes (corresponding to 76 APA sites) were associated with at least one type of cancer, including 25 genes previously not linked to cancer susceptibility. Of the identified risk APAs, 97.4% and 26.3% were supported by 3′-UTR APA quantitative trait loci and colocalization analyses, respectively. Luciferase reporter assays for four selected putative regulatory 3′-UTR variants demonstrated that the risk alleles of 3′-UTR variants, rs324015 (STAT6), rs2280503 (DIP2B), rs1128450 (FBXO38), and rs145220637 (LDHA), significantly increased the posttranscriptional activities of their target genes compared with reference alleles. Furthermore, knockdown of the target genes confirmed their ability to promote proliferation and migration. Overall, this study provides insights into the role of APA in the genetic susceptibility to common cancers.
Significance: Systematic evaluation of associations of alternative polyadenylation with cancer risk reveals 58 putative susceptibility genes, highlighting the contribution of genetically regulated alternative polyadenylation of 3′UTRs to genetic susceptibility to cancer.
Abstract A002: Assessment of the diagnostic accuracy of Oncuria-Detect® for detection of upper tract urothelial carcinoma
Authors: Sakatani Toru , Tanaka Sunao , Fujita Kazutoshi , Linehan Jennifer , Murakami Kaoru , Lee Riko , Pagano Ian , Rosser Charles , Furuya Hideki 
Published: May 2024

Abstract
Introduction and Objective: Due to insufficient accuracy, urine-based assays currently have a limited role in the management of patients with upper tract urothelial carcinoma (UTUC). The application of a robust urine-based multiplex assay, Oncuria-Detect®, to aid in the detection of UTUC has the potential to address this deficiency and to assist with accurate, non-invasive diagnosis. Methods: To evaluate the performance of Oncuria-Detect®, a multiplex immunoassay capable of querying a voided urine sample for 10 protein biomarkers associated with urothelial carcinoma (A1AT, APOE, ANG, CA9, IL8, MMP9, MMP10, PAI1, SDC1 and VEGFA). Its application to UTUC was evaluated in a multi-institutional cohort of 35 prospectively collected subjects presenting for evaluation of upper tract mass along with 46 prospective collected matched controls (i.e., non-tumor bearing). The ability of the test to identify patients harboring UTUC was assessed. UTCU status was confirmed by endoscopy and tissue biopsy or definitive surgery. Diagnostic performance was assessed using ROC curves. Results: Oncuria-Detect® provided an AUC of 0.886 (95% CI: 0.807-0.964) with an overall sensitivity of 91.4%, specificity of 73.9%, NPV 91.9% and PPV 72.7%. Sensitivity values of the diagnostic panel for low-grade UTUC, high-grade UTUC, non-invasive UTUC and invasive UTUC were 86.7%, 90.9%, 88.9% and 94.1%, respectively. Urinary cytology or selective ureteral washing/cytology was associated with an overall sensitivity of 54.2%, specificity of 100%, NPV 63.3% and PPV 100%. Sensitivity values of cytology for low-grade UTUC, high-grade UTUC, non-invasive UTUC and invasive UTUC were 100%, 100%, 100%, and 77.8%, respectively. Conclusions: Urinary levels of a biomarker panel enabled the accurate discrimination of UTUC and controls non-tumor bearing individuals. The multiplex Oncuria-Detect® test can achieve the efficient and accurate detection of UTUC in a non-invasive patient setting.
Citation Format: Toru Sakatani, Sunao Tanaka, Kazutoshi Fujita, Jennifer Linehan, Kaoru Murakami, Riko Lee, Ian Pagano, Charles Rosser, Hideki Furuya. Assessment of the diagnostic accuracy of Oncuria-Detect® for detection of upper tract urothelial carcinoma [abstract]. In: Proceedings of the AACR Special Conference on Bladder Cancer: Transforming the Field; 2024 May 17-20; Charlotte, NC. Philadelphia (PA): AACR; Clin Cancer Res 2024;30(10_Suppl):Abstract nr A002.
Abstract B013: Novel prognostic score for patients with metastatic bladder cancer on immunotherapy
Authors: Chauhan Vishwani , Diaz Sofia Silva , Jara Pablo , Efovi Denis , Gurung Ayushma , Young Matthew , Wells Connor , Nally Elizabeth , Szabados Bernadett , Powles Thomas , Jackson-Spence Francesca 
Published: May 2024

Abstract
Background: Some patients with metastatic bladder cancer (mBC) have durable responses to immune checkpoint inhibitors (ICIs); others progress early while suffering from autoimmune toxicity. Currently there is no prognostic score or tumour marker to predict who will benefit from ICIs in bladder cancer. We designed a novel prognostic score to stratify response to ICIs in patients with mBC. Methods: We analysed data from patients with mBC receiving ICIs as second- or later-line treatment between 2013–2023. We assessed key patient characteristics and their impact on progression-free survival (PFS) and overall survival (OS) using Kaplan-Meier and Cox-regression methods (retained if p&lt;0.05). Variables independently correlated with OS and PFS on multivariate analysis were selected to create a new scoring model. Radiological response to ICIs was assessed. C-statistic was calculated to assess the model’s fit. Results: 149 patients with mBC were identified as having received second- or later-line ICIs. Median OS was 9.3 months and PFS 2.5 months. On multivariate analysis, absent liver and bone metastases, haemoglobin≥100g/L, ALP≤130 unit/L, NLR&gt;5, and time from last therapy ≥6 months were independently associated with improved OS and PFS. Using these variables, we created a 3-tier model that strongly correlated with OS (HR 2.0, 95% CI 1.4–2.4, p&lt;0.001) and PFS (HR 1.7, 95% CI 1.2–2.0, p&lt;0.001). Median OS for patients with 0-1, 2 and 3-5 risk factors was 24.2, 6.7, and 2.4 months, respectively. Complete or partial response was seen in 45.8%, 21.2%, and 6.5%, respectively. Disease control was seen in 62.5%, 39.4%, and 10.9% respectively. This model achieved a C-statistic of 0.70 (95% CI 0.65-0.75). Conclusions: ICIs with enfortumab vedotin will become first-line therapy for most patients with mBC. We used routinely available metrics to develop a new 3-tier model that strongly stratifies outcomes of patients with mBC receiving second- or later-line ICIs. The model requires external validation.
Citation Format: Vishwani Chauhan, Sofia Silva Diaz, Pablo Jara, Denis Efovi, Ayushma Gurung, Matthew Young, Connor Wells, Elizabeth Nally, Bernadett Szabados, Thomas Powles, Francesca Jackson-Spence. Novel prognostic score for patients with metastatic bladder cancer on immunotherapy [abstract]. In: Proceedings of the AACR Special Conference on Bladder Cancer: Transforming the Field; 2024 May 17-20; Charlotte, NC. Philadelphia (PA): AACR; Clin Cancer Res 2024;30(10_Suppl):Abstract nr B013.
First record of the three-spined box crab, Arcania undecimspinosa De Haan, 1841 (Decapoda, Brachyura, Leucosiidae) from the Arabian Sea, with a key to the species of Arcania recorded from the Indian coast
Authors: Sureandiran B. , Dave T. H. , Solanki J. B. , Karuppasamy K. , Vidhya V. , Suyani N. K. 
Published: May 2024

Abstract
A single specimen of the three-spined box crab, Arcania undecimspinosa De Haan, 1841, measuring 21.0 mm CW and 20.5 mm CL, is here documented for the first time from the Arabian Sea along the north-west coast of India. Previously, the species has been only reported from the Bay of Bengal region along the Indian coast. The present study provides a detailed taxonomic description of the species with high-resolution colour photographs and line drawings, along with a key to the species of the genus Arcania known from the Indian coast.
R2P, the Imperial Critique, and Self-Determination: Recovering the Narrative of the Tlaxcaltecas
Authors: Brunstetter Daniel R. , Lobo Francisco 
Published: May 2024

Abstract
Scholars look to early modern canonical texts to understand the philosophical underpinnings of R2P. Meanwhile, critiques argue these origins couch Western imperial intentions. This article complicates the story by returning to a pivotal historical moment – the Spanish encounter with the Aztecs – to explore protective war from an overlooked angle: that of Spain’s indigenous allies, the Tlaxcaltecas. Despite being oppressed by the imperialistic Aztecs, canonical Western texts related to R2P and post-colonial critiques both elide the Tlaxcaltecas’ precarious agency – the rights and duties moulded by endemic structures of violence before, during, and after protective intervention – by problematically embracing simple binaries of European oppressor and indigenous oppressed. Restoring the Tlaxcaltecas to the story complicates tropes about imperial projections of force and the pervasive assumption in R2P discussions of the ‘innocent oppressed’. Our conclusions provide new perspective from which to view future Pillar 3 dilemmas by recognising that the protected sometimes have a bellicose role to play.
Nietzsche and the Mysticism of Apotheosis
Authors: Carollo Brett 
Published: May 2024

Abstract
This paper argues that Friedrich Nietzsche was a mystic and that his post-Gay Science (1882) thought should be understood as an unfolding expression of his mystical experiences. Drawing on Nietzsche’s Nachlass (notes), letters, and published writings, I show that he undoubtedly had at least two major mystical experiences and that these experiences were the source of all the cardinal motifs of his later thought. The apparent tensions or paradoxes between Nietzsche’s cardinal teachings, above all that between the superman and the eternal recurrence, are resolved once they are understood as products of a mystical epistemology derived from an intuitive source of knowledge purportedly beyond the dualities intrinsic to ordinary modes of cognition. This intuitio mystica, which Nietzsche declared to be the real purpose of all philosophy, is coextensive with a type of mysticism I call apotheosis, based on the individual ego’s identification with a unity underlying all reality.
Synoptic-Scale Meteorological Patterns Associated with Heavy Rainfall in the Minnesota Region
Authors: Laiho Rory , Friedrich Katja , Winters Andrew C. 
Published: May 2024

Abstract
Situated in the Upper Midwest, Minnesota’s midcontinental location places it in a climate transition zone between eastern U.S. humid conditions and western semiarid conditions as well as between warm, moist air from the Gulf of Mexico to the south and drier, polar air to the north. Potential adverse impacts on ecosystems due to changing climate and precipitation patterns, together with ongoing flash flooding risks, indicate that heavy rainfall occurrence and distribution are important considerations for Minnesota. This research used ERA5 reanalysis data with 0.25° grid spacing during May–September 1959–2021 to investigate the synoptic-scale drivers of Minnesota heavy rainfall. The study utilized a neural network, self-organizing map (SOM) technique to identify sea level pressure patterns and precipitation patterns associated with heavy rainfall and used composite analysis to explore the relationships between synoptic-scale conditions and environmental parameters during heavy rain hours. Six sea level pressure patterns were identified, three of which represented advancing surface cyclones and accounted for >70% of the heavy rain hours. The spatial distribution of heavy rainfall was represented by six precipitation patterns. The greatest frequency of heavy rain hours was associated with the northwest precipitation pattern, followed by the southwest and southeast patterns. Analysis of the frequency of pressure and heavy rain precipitation pattern pairs revealed that the top five most frequent pairs were associated with advancing surface cyclones and >26% of the total heavy rain hours. Composite analysis of environmental parameters showed that favorable conditions related to moisture and lift were associated with heavy rainfall.
How do Patients With Advanced Cancer and Family Caregivers Accommodate One Another in Decision-Making? Findings From a Qualitative Study in Specialist Palliative Care
Authors: Foley Geraldine , McCauley Rachel , McQuillan Regina , Ryan Karen 
Published: May 2024

Background Patients with advanced cancer commonly involve family caregivers in decision-making for palliative care. However, how patients with advanced cancer and family caregivers accommodate each other in decision-making is unclear. Methods A qualitative study in advanced cancer was conducted with 14 patients and 19 family caregivers recruited from two hospices comprising a large regional specialist palliative care service in Ireland. Data comprised semi-structured interviews with participants. The data were analyzed using grounded theory coding procedures. Results Most patients preferred to make care decisions with their family caregiver or at least involve their family caregiver in care discussions. Patients engaged in shared decision-making because they felt they benefited from caregiver support. Patients accommodated family caregiver preferences out of concern for that person and because they trusted them. Family caregivers accommodated patient preferences because they wanted to honor the patient’s wishes and felt a responsibility to protect patient autonomy when they had a close relationship with the patient. Prior conflict between the patient and family caregiver was a barrier to mutual accommodation. Although concealment was used as a mechanism to support accommodation between the patient and family caregiver, both sought to communicate openly with other family members to negate potential conflict between each other and the wider family. Conclusion Patients with advanced cancer and family caregivers in specialist palliative care support one another by accommodating each other’s preferences for patient care. Patients with advanced cancer and family caregivers accommodate one another in decision-making out of a sense of responsibility to one another.
Being able to be myself: Understanding autonomy and autonomy-support from the perspectives of autistic adults with intellectual disabilities
Authors: Ryan Jackie , Brown Heather M , Borden Anne , Devlin Christina , Kedmy Adam , Lee Austin , Nicholas David B , Kingsley Bethan , Thompson-Hodgetts Sandy 
Published: May 2024

Self-determination enhances a person’s quality of life and is a fundamental human right. According to self-determination theory, autonomy is one of three basic psychological needs that must be met to experience self-determination. The overarching aim of this exploratory study was to learn about autonomy from the perspective of autistic adults with intellectual disability, including what autonomy meant and how participants wanted to be supported to be autonomous. Participants ( n = 8; median age = 24) engaged in a variety of participatory methods (e.g. discussions, arts and crafts, games) during weekly sessions. These sessions took place over 7–16 weeks and were each informed by a guiding question related to autonomy. Artifacts, video or audio recordings from each session, and reflexive journals were thematically analyzed. The results support an overarching meaning of autonomy as being able to be themselves. Participants identified (1) choice and control, (2) communicating their way, and (3) safe environments as important and showed us how they wanted to be supported in each of these three areas. We also identified having autistic facilitators as an overarching strategy. These results provide a foundation for implementing change to enhance autonomy for autistic adults with intellectual disabilities. Lay Abstract Autistic young adults with intellectual disabilities want to be autonomous but are less autonomous than other people. However, they can be autonomous with appropriate support. We wanted to learn how we can support autistic adults with intellectual disabilities to be more autonomous. We designed our study with help from five autistic community partners to make sure the research was relevant to autistic people and would improve their lives. We talked with eight autistic young adults with intellectual disabilities about autonomy. We defined “talk” as verbal language, as well as non-verbal cues such as body language, facial expressions, vocalizations, and laughter. We did art projects and played games while we talked. We met in small groups over multiple sessions. Our participants told us that being autonomous meant being able to be themselves. They told us three main ways to support their autonomy: (1) having choice and control, (2) being able to communicate in their own way, and (3) being in a safe environment. Families, support staff, and caregivers can use this information to help autistic young adults with intellectual disabilities to be autonomous.
Trade-offs Between Accuracy and Health Outcomes in Algorithms for Home Blood Pressure Monitoring Devices
Authors: Henderson Austin , Fyfe-Johnson Amber L. , Dillard Denise , Schaefer Krista , Todd Michael , Muller Clemma J. , Umans Jason G. , Rosenman Robert 
Published: May 2024

Objectives Home blood pressure monitoring (HBPM) is crucial for managing hypertension, but there is a potential trade-off between measurement accuracy and health/economic outcomes due to asymmetric costs associated with misclassifying an individual as having hypertension or not. We assessed whether adjustments to device readings that increased overall accuracy produced net health and economic benefits. Methods We analyzed data from N  =  89 Alaska Native individuals who used 2 HBPM devices and a standard aneroid sphygmomanometer. We modeled changes in expected costs associated with individuals being misclassified as hypertensive or not under 3 different models of adjusting HBPM device readings. Results The gains in accuracy produced by adjusting HBPM readings decreased the overall rate of hypertension misclassification but increased the rate of false-negative readings. Adjusting readings led to a net increase in expected health and economic costs. Discussion Ignoring asymmetric costs of misclassification can escalate overall costs and worsen uncontrolled hypertension. Home blood pressure monitoring algorithms must be cautiously designed, considering both false negatives and positives. Greater transparency in HBPM algorithms is needed for effective coordination among manufacturers, clinicians, and patients.
Savelievaite, Mg2CrO2(BO3), the first natural borate with species-defining Cr3+ and the ludwigite–savelievaite isomorphous series
Authors: Pekov Igor V. , Vakhrusheva Nadezhda V. , Zubkova Natalia V. , Yapaskurt Vasiliy O. , Shelukhina Yulia S. , Erokhin Yuriy V. , Bulakh Maria O. , Britvin Sergey N. , Kasatkin Anatoly V. , Turchkova Anna G. , Pushcharovsky Dmitry Yu. 
Published: May 2024

AbstractThe new ludwigite-group mineral savelievaite, ideally Mg2Cr3+O2(BO3), was found in the chromitite body at the Malaya Kharamatalou river valley, Voikar–Syninskiy ultrabasic complex, Polar Urals, Russia. Savelievaite and Cr-enriched ludwigite occur in clinochlore veinlets and are associated with earlier magnesiochromite, spinel, chromite, pargasite, diopside, forsterite, serpentine, magnetite and pentlandite. Savelievaite forms prismatic, acicular or fibrous crystals up to 0.05 × 0.4 mm, usually assembled in radiating or chaotic clusters up to 1 × 1.5 mm across. It is opaque, black to greenish-black. The lustre is vitreous for prismatic crystals and silky for fibrous aggregates. D(calc.) = 3.91 g cm–3. Under the microscope in reflected light, savelievaite is grey, non-pleochroic, with weak bireflectance and anisotropism. The chemical composition (wt.%, EMPA, Fe2+:Fe3+ ratio by stoichiometry) is: MgO 34.88, FeO 10.83, NiO 0.36, B2O3 16.80, Al2O3 2.97, V2O3 0.21, Cr2O3 21.97, Fe2O3 12.40, TiO2 0.43, total 100.85. The empirical formula calculated on the basis of 5 O apfu is (Mg1.72Fe2+0.30Ni0.01)Σ2.03(Cr3+0.57Fe3+0.31Al0.12Ti0.01V3+0.01)Σ1.02B0.96O5. Savelievaite is orthorhombic, space group Pbam, a = 9.2631(6), b = 12.2298(8), c = 3.0104(2) Å, V = 341.04(4) Å3 and Z = 4. The strongest reflections of the powder X-ray diffraction pattern [d,Å(I)(hkl)] are: 5.101(100)(120); 2.551(90)(240); 2.524(88)(201); 2.163(36)(250); and 2.033(55)(321). The crystal structure was solved from single-crystal X-ray diffraction data and refined to R1 = 0.0405. Savelievaite is isostructural with ludwigite, Cr3+ is concentrated at the M4 site. The mineral is named in honour of the Russian petrologist and geologist Dr. Galina Nikolaevna Savelieva (b. 1936). Ludwigite, ideally Mg2Fe3+O2(BO3), and savelievaite form a continuous isomorphous series in which Cr3+ content varies from 0 to 0.60 apfu. Occurrences of Cr-enriched (>1 wt.% Cr2O3) varieties of ludwigite are mainly related to ultrabasic complexes. The Cr-richest (>10 wt.% Cr2O3) ludwigite–savelievaite-series members are found in chromite ores at the Voikar–Syninskiy complex and Volchiegorskoe and Tatishchevskoe deposits, both in the South Urals.