bluuebunny/crossref_metadata_2025_split huggingface dataset:
A linear model predictive control algorithm for nonlinear large‐scale distributed parameter systems
Authors: Bonis Ioannis , Xie Weiguo , Theodoropoulos Constantinos 
Published: March 2011

AbstractThis work provides a framework for linear model predictive control (MPC) of nonlinear distributed parameter systems (DPS), allowing the direct utilization of existing large‐scale simulators. The proposed scheme is adaptive and it is based on successive local linearizations of the nonlinear model of the system at hand around the current state and on the use of the resulting local linear models for MPC. At every timestep, not only the future control moves are updated but also the model of the system itself. A model reduction technique is integrated within this methodology to reduce the computational cost of this procedure. It follows the equation‐free approach (see Kevrekidis et al., Commun Math Sci. 2003;1:715–762; Theodoropoulos et al., Proc Natl Acad Sci USA. 2000;97:9840‐9843), according to which the equations of the model (and consequently of the simulator) need not be given explicitly to the controller. The latter forms a “wrapper” around an existing simulator using it in an input/output fashion. This algorithm is designed for dissipative DPS, dissipativity being a prerequisite for model reduction. The equation‐free approach renders the proposed algorithm appropriate for multiscale systems and enables it to handle large‐scale systems. © 2011 American Institute of Chemical Engineers AIChE J, 2012
P2RX7 gene is associated consistently with mood disorders and predicts clinical outcome in three clinical cohorts
Authors: Soronen Pia , Mantere Outi , Melartin Tarja , Suominen Kirsi , Vuorilehto Maria , Rytsälä Heikki , Arvilommi Petri , Holma Irina , Holma Mikael , Jylhä Pekka , Valtonen Hanna M. , Haukka Jari , Isometsä Erkki , Paunio Tiina 
Published: March 2011

AbstractWe investigated the effect of nine candidate genes on risk for mood disorders, hypothesizing that predisposing gene variants not only elevate the risk for mood disorders but also result in clinically significant differences in the clinical course of mood disorders. We genotyped 178 DSM‐IV bipolar I and II and 272 major depressive disorder patients from three independent clinical cohorts carefully diagnosed with semistructured interviews and prospectively followed up with life charts for a median of 60 (range 6–83) months. Healthy control subjects (n = 1322) were obtained from the population‐based national Health 2000 Study. We analyzed 62 genotyped variants within the selected genes (BDNF, NTRK2, SLC6A4, TPH2, P2RX7, DAOA, COMT, DISC1, and MAOA) against the presence of mood disorder, and in post‐hoc analyses, specifically against bipolar disorder or major depressive disorder. Estimates for time ill were based on life charts. The P2RX7 gene variants rs208294 and rs2230912 significantly elevated the risk for a familial mood disorder (OR = 1.35, P = 0.0013, permuted P = 0.06, and OR = 1.44, P = 0.0031, permuted P = 0.17, respectively). The results were consistent in all three cohorts. The same risk alleles predicted more time ill in all cohorts (OR 1.3, 95% CI 1.1–1.6, P = 0.0069 and OR 1.7, 95% CI 1.3–2.3, P = 0.0002 with rs208294 and rs2230912, respectively), so that homozygous carriers spent 12 and 24% more time ill. P2RX7 and its risk alleles predisposed to mood disorders consistently in three independent clinical cohorts. The same risk alleles resulted in clinically significant differences in outcome of patients with major depressive and bipolar disorder. © 2011 Wiley‐Liss, Inc.
Familial 6p22.2 duplication associates with mild developmental delay and increased SSADH activity
Authors: Siggberg Linda , Mustonen Aki , Schuit Robert , Salomons Gajja S. , Roos Birthe , Gibson K. Michael , Jakobs Cornelis , Ignatius Jaakko , Knuutila Sakari 
Published: March 2011

AbstractWe present a family with mild developmental delay and a duplication (6)(p22.2). Array CGH analyses revealed this 0.7 Mb duplication in all three patients, spanning candidate genes ALDH5A1, DCDC2, and KIAA0319. Results were confirmed by MLPA analysis of the dyslexia genes DCDC2 and KIAA0319. Of interest, ALDH5A1 encodes succinate semialdehyde dehydrogenase (SSADH), an enzyme responsible for γ‐amino‐butyric acid (GABA) degradation. Inherited deficiency of SSADH results in accumulation of the neuromodulator γ‐hydroxybutyrate (GHB), which likely contributes to some aspects of the neurological phenotype of SSADH deficiency (MIM #271980). Based on autosomal‐recessive inheritance, we sequenced ALDH5A1 in all patients, which revealed no pathogenic mutations. SSADH enzyme studies in cultured white cells confirmed elevated SSADH activity, consistent with the duplication, whereas concentrations of SSA were slightly elevated in urine, suggesting oxidant stress. We speculate that the duplication (6)(p22.2) and corresponding hyperactive level of SSADH activity may have negative consequences for GABA metabolism and the role of SSADH in other metabolic sequences. © 2011 Wiley‐Liss, Inc.
Nucleic Acid Based Molecular Devices
Authors: Krishnan Yamuna , Simmel Friedrich C. 
Published: March 2011

AbstractIn biology, nucleic acids are carriers of molecular information: DNA’s base sequence stores and imparts genetic instructions, while RNA’s sequence plays the role of a messenger and a regulator of gene expression. As biopolymers, nucleic acids also have exciting physicochemical properties, which can be rationally influenced by the base sequence in myriad ways. Consequently, in recent years nucleic acids have also become important building blocks for bottom‐up nanotechnology: as molecules for the self‐assembly of molecular nanostructures and also as a material for building machinelike nanodevices. In this Review we will cover the most important developments in this growing field of nucleic acid nanodevices. We also provide an overview of the biochemical and biophysical background of this field and the major “historical” influences that shaped its development. Particular emphasis is laid on DNA molecular motors, molecular robotics, molecular information processing, and applications of nucleic acid nanodevices in biology.
Study on surface functional group characteristics of Yanzhou coal for thermal maturity
Authors: Sun Lushi , Shi Jinming , Xiang Jun , Hu Song , Su Sheng , Xu Chaofen , Xu Kai 
Published: March 2011

ABSTRACTTo reveal the changing rule of coal structure during coal gasification, Yanzhou coal was used to make raw coal char, acid‐washed coal char and semi‐cokes in tube furnace at different temperatures, 300–1000 °C, and the infrared spectra were monitored by Fourier transform infrared spectroscopy at every gasification conditions, to analyze the surface functional group characteristics of Yanzhou coal. It was found that the absorption peaks of NH group, as well as free SH and SiO groups, of raw coal were removed during acid‐washing; char‐making temperature had influence on organic groups of raw coal greatly, but little on SiO groups and organic sulfur groups; the function of heating rate was activated only when the temperature reaches a certain role, and heating rate was selective on the characteristic group formation; for semi‐cokes, limited aliphatic structure in coal led to small hydrocarbon generation capacity during coal gasification at low temperature, but the synergistic effect of aromatic structure cracking and condensation increases the hydrogen‐enriched degree of semi‐cokes at high temperature; aliphatic and aromatic structures were affected little by low temperature, and the original aliphatic structure broke off firstly with increasing temperature, whereas at high temperature, aromatic structure began to crack to aliphatic structure to break off gradually; CO2 participating in gasification, intervening CO group of phenols, ethers, alcohols and esters could influence the total oxygen‐enriched efficiency of semi‐cokes. © 2011 Curtin University of Technology and John Wiley & Sons, Ltd.
Oligodendroglial Cells Express and Secrete Reelin
Authors: Siebert Justin R. , Osterhout Donna J. 
Published: March 2011

AbstractOligodendrocyte (OL) progenitor cells (OPCs) give rise to the myelinating cells of the central nervous system (CNS), the OL. To examine molecular changes involved in OPC differentiation, a microarray analysis was performed at several time points during OPC maturation. The results revealed significant expression levels of mRNA for reelin, one reelin receptor, very low density lipoprotein receptor (Vldlr), and the cytoplasmic adaptor molecule, disabled homolog 1 (Dab1). The expression of these proteins in oligodendroglial (ODG) cells was confirmed by immunocytochemistry and Western blot analysis. It was also discovered that both progenitors and mature OLs secrete reelin. Although there is no known effect of reelin on ODG cells, the data suggest that these cells may be a source of reelin in the CNS. Anat Rec, 2011. © 2011 Wiley‐Liss, Inc.
Characterization of the Anchoring Morphology and Mineral Content of the Anterior Cruciate and Medial Collateral Ligaments of the Knee
Authors: Sinclair Kristofer D. , Curtis Benjamin D. , Koller Karyn E. , Bloebaum Roy D. 
Published: March 2011

AbstractThe manner in which ligament connects to bone remains an area of interest for researchers, bioengineers, and clinicians. Stable fixation of an anterior cruciate ligament (ACL) graft has been shown to be paramount to preventing excess anterior tibial translation and to restoring the normal kinematics of the knee joint. In this study, the surface area of attachment and the mineral characteristics of the ACL and medial collateral ligament (MCL) attachment sites were characterized to determine the factors that contributed to ligament attachment strength. Findings from this study indicated that the area of attachment of the ACL's insertion was significantly greater than the ligament's origin (95.8 mm2 ± 21.5 vs. 73.2 mm2 ± 16.2, P = 0.009). Additionally, the ACL was measured to have a greater surface area of attachment when compared with the MCL (84.5 mm2 ± 18.8 vs. 58.2 mm2 ± 23.8, P = 0.005); although, the MCL was observed to have a greater region of calcified fibrocartilage (CFC) than the ACL (533.0 μm ± 116.9 vs. 195.5 μm ± 36.6, P = 0.0003). No significant correlation was observed between the ligament's area of attachment and the thickness of the CFC region. Measurements of ash percent suggested that the boundary region, between the CFC and host bone, possessed the least mineral content for the three regions of interest. These data suggest that ligament attachment strength can be attributed to several factors, including the ligament's area of attachment, regional thickness, and mineral content of the CFC. Anat Rec,, 2011. © 2011 Wiley‐Liss, Inc.
Anatomical Sciences Education Vol. 4, Issue 2, 2011 Cover Image
Authors: Higazi Tarig B. 
Published: March 2011

AbstractAnatomy and Physiology undergraduate students learn histology using live digital imaging of microscopic slides on a SMART board. The interactive live digital imaging system consists of a digital camera‐equipped microscope that projects images from glass slides on a wall‐mounted SMART board via a classroom computer. This setup allows the instructor to make real‐time annotations of key structural components of the cells and tissues. In this issue of ASE, Dr. Higazi from the Department of Biological Sciences at the Ohio University Zanesville Campus discusses the impact of interactive live digital imaging technology on students' performance in his undergraduate A&P course. The photograph (taken by Ms. Christine Shaw, Director of Public Relations at Ohio University Zanesville Campus) shows Dr. Higazi and his students discussing different epithelial cell characteristics found in the medulla of the kidney.
Passive multivariable temperature and conductivity RFID sensors for single‐use biopharmaceutical manufacturing components
Authors: Potyrailo Radislav A. , Wortley Timothy , Surman Cheryl , Monk David , Morris William G. , Vincent Mark , Diana Rafael , Pizzi Vincent , Carter Jeffrey , Gach Gerard , Klensmeden Staffan , Ehring Hanno 
Published: March 2011

AbstractSingle‐use biopharmaceutical manufacturing requires monitoring of critical manufacturing parameters. We have developed an approach for passive radio‐frequency identification (RFID)‐based sensing that converts ubiquitous passive 13.56 MHz RFID tags into inductively coupled sensors. We combine several measured parameters from the resonant sensor antenna with multivariate data analysis and deliver unique capability of multiparameter sensing and rejection of environmental interferences with a single sensor. We demonstrate here the integration of these RFID sensors into single‐use biopharmaceutical manufacturing components. We have tested these sensors for over 500 h for measurements of temperature and solution conductivity with the accuracy of 0.1°C (32–48°C range) and accuracy of 0.3–2.9 mS/cm (0.5–230 mS/cm range). We further demonstrate simultaneous temperature and conductivity measurements with an individual RFID sensor with the accuracy of 0.2°C (5–60°C range) and accuracy of 0.9 mS/cm (0.5–183 mS/cm range). Developed RFID sensors provide several important features previously unavailable from other single‐use sensing technologies such as the same sensor platform for measurements of physical, chemical, and biological parameters; multi‐parameter monitoring with individual sensors; and simultaneous digital identification. © 2011 American Institute of Chemical Engineers Biotechnol. Prog., 2011
Effects of extracellular matrices derived from different cell sources on chondrocyte functions
Authors: Hoshiba Takashi , Lu Hongxu , Yamada Tomoe , Kawazoe Naoki , Tateishi Tetsuya , Chen Guoping 
Published: March 2011

AbstractCell‐derived extracellular matrices (ECMs) are a key factor in regulating cell functions in tissue engineering and regenerative medicine. The fact that cells are surrounded by their specific ECM in vivo elicits the need to elucidate the effects of ECM derived from different cell sources on cell functions. Here, three types of ECM were prepared by decellularizing cultured chondrocytes, fibroblasts, and mesenchymal stem cells (MSC) and used for chondrocyte culture to compare their effects on chondrocyte adhesion, proliferation, and differentiation. Chondrocyte adhesion to the chondrocyte‐derived ECM was greater than those to the fibroblast‐ and MSC‐derived ECM. Chondrocyte proliferation on the chondrocyte‐derived ECM was lower than those on the fibroblast‐ and MSC‐derived ECM. The ECM showed no evident effect on chondrocyte differentiation. The effects of ECM on cell functions depended on the cell source used to prepare the ECM. © 2011 American Institute of Chemical Engineers Biotechnol. Prog., 2011
Process evaluations and economic analyses of recombinant human lysozyme and hen egg‐white lysozyme purifications
Authors: Wilken Lisa R. , Nikolov Zivko L. 
Published: March 2011

AbstractHuman lysozyme and hen egg‐white lysozyme have antibacterial, antiviral, and antifungal properties with numerous potential commercial applications. Currently, hen egg‐white lysozyme dominates low cost applications but the recent high‐level expression of human lysozyme in rice could provide an economical source of lysozyme. This work compares human lysozyme and hen egg‐white lysozyme adsorption to the cation exchange resin, SP‐Sepharose™ FF, and the effect of rice extract components on lysozyme purification. With one exception, the dynamic binding capacities of human lysozyme were lower than those of hen egg‐white at pH 4.5, 6, and 7.5 with ionic strengths ranging from 0 to 100 mM (5–20 mS). Ionic strength and pH had a similar effect on the adsorption capacities, but human lysozyme was more sensitive to these two factors than hen egg‐white lysozyme. In the presence of rice extract, the dynamic binding capacities of human and hen egg‐white lysozymes were reduced by 20–30% and by 32–39% at pH 6. Hen egg‐white lysozyme was used as a benchmark to compare the effectiveness of human lysozyme purification from transgenic rice extract. Process simulation and cost analyses for human lysozyme purification from rice and hen egg‐white lysozyme purification from egg‐white resulted in similar unit production costs at 1 ton per year scale. © 2011 American Institute of Chemical Engineers Biotechnol. Prog., 2011
Cell clarification and size separation using continuous countercurrent magnetophoresis
Authors: Bucak Seyda , Sharpe Sonja , Kuhn Simon , Hatton T. Alan 
Published: March 2011

AbstractNonmagnetic microparticles (e.g., cells, polymer beads) immersed in a magnetic fluid (ferrofluid) under a nonuniform magnetic field experience a magnetophoretic force in the direction of decreasing magnetic field strength. This phenomenon was exploited in the development of a continuous magnetophoretic countercurrent separation for the removal and concentration of micron‐sized particles from aqueous suspensions, and in particular as a viable approach for cell clarification of raw fermentation broth. A magnetic fluid is added to the cell suspension, the mixture is introduced to the magnetic separator, which consists of an open flow tube passing between pairs of magnets that move in a direction counter to the flow of the suspension. The cells are pushed ahead of the magnet pairs owing to the magnetophoretic forces acting on them, collected in a tube upstream of the feed injection point, and removed as a concentrated suspension for further treatment. © 2011 American Institute of Chemical Engineers Biotechnol. Prog., 2011
Posterior tibial artery access using transradial techniques: Retrograde approach to inaccessible lower extremity lesions
Authors: Londoño Juan Carlos , Singh Vikas , Martinez Claudia A. 
Published: March 2011

AbstractPercutaneous intervention of chronic limb ischemia is often limited by vascular access especially in patients with previous surgical interventions. This warrants development of alternative endovascular techniques, particularly for patients in whom traditional ipsilateral antegrade or contralateral retrograde access has failed or is not possible. We describe a novel approach to the posterior tibial artery using retrograde access with transradial techniques including closure devices in two patients with inaccessible antegrade access. © 2011 Wiley Periodicals, Inc.
Fe3O4/WO3 Hierarchical Core–Shell Structure: High‐Performance and Recyclable Visible‐Light Photocatalysis
Authors: Xi Guangcheng , Yue Bing , Cao Junyu , Ye Jinhua 
Published: March 2011

AbstractA facile solvothermal epitaxial growth combined with a mild oxidation route has been developed for the fabrication of a magnetically recyclable Fe3O4/WO3 core–shell visible‐light photocatalyst. In this core–shell structured photocatalyst, visible‐light‐active WO3 nanoplates (the shells) with high surface area are used as a medium to harvest absorbed photons and convert them to photogenerated charges, while conductive Fe3O4 microspheres (the cores) are used as charge collectors to transport the photogenerated charges. This is a new role for magnetite. The Fe3O4/WO3 core–shell structured photocatalysts possess large surface‐exposure area, high visible‐light‐absorption efficiency, stable recyclability, and efficient charge‐separation properties, the combination of which has rarely been reported in other visible‐light‐active photocatalysts. Photoelectrochemical investigations verify that the core–shell structured Fe3O4/WO3 has a more effective photoconversion capability than pure WO3 or Fe3O4. At the same time, the visible‐light photocatalytic ability of the Fe3O4/WO3 photocatalyst has significantly enhanced activity in the photodegradation of organic‐dye materials. The results presented herein provide new insights into core–shell materials as high‐performance visible‐light photocatalysts and their potential use in environmental protection.
N‐2‐Aryl‐1,2,3‐triazoles: A Novel Class of UV/Blue‐Light‐Emitting Fluorophores with Tunable Optical Properties
Authors: Yan Wuming , Wang Qiaoyi , Lin Quan , Li Minyong , Petersen Jeffrey L. , Shi Xiaodong 
Published: March 2011

AbstractThe N‐2‐aryl‐1,2,3‐triazole derivatives (NATs) were developed as a new class of UV/blue‐light‐emitting fluorophores. Though both N‐1‐aryl‐1,2,3‐triazoles and N‐2‐aryl‐1,2,3‐triazoles gave strong photo absorption under excitation at 330 nm, only the N‐2‐analogous showed strong fluorescence emission in the UV/blue range with high efficiency in various solvents (quantum yield Φ around 0.3–0.5). Significant substituted group effects were observed, allowing tunable optical properties with emission (λmax) from 350–400 nm and Stokes shift from 38–93 nm. The computational studies along with X‐ray crystal structures indicated the significance of the effective conjugation between triazole ring and aryl groups on the N‐2 position. The planar intramolecular charge transfer (PICT) mechanism was proposed, which was supported by solvent effect studies. Simple derivatizations gave NAT‐modified lysine and strong UV/blue emitting bis‐NAT (Φ=0.76, λmax=390), which suggested the great potential of this new class of fluorophores in biological and material science research.
Synthesis, Characterization, and Photoinduced Energy and Electron Transfer in a Supramolecular Tetrakis (Ruthenium(II) Phthalocyanine) Perylenediimide Pentad
Authors: Jiménez Angel J. , Grimm Bruno , Gunderson Victoria L. , Vagnini Michael T. , Krick Calderon Sandra , Rodríguez‐Morgade M. Salomé , Wasielewski Michael R. , Guldi Dirk M. , Torres Tomás 
Published: March 2011

AbstractMetal coordination was probed as a versatile approach for designing a novel electron donor/acceptor hybrid [PDIpy4{Ru(CO)Pc}4] (1), in which four pyridines placed at the bay region of a perylenediimides (PDIpy4) coordinate with four ruthenium phthalocyanine units [Ru(CO)Pc]. This structural motif was expected to promote strong electronic coupling between the electron donors and the electron acceptor, a hypothesis that was confirmed in a full‐fledged physicochemical investigation focusing on the ground and excited state reactivities. As far as the ground state is concerned, absorption and electrochemical assays indeed reveal a notable redistribution of electron density, that is, from the electron‐donating [Ru(CO)Pc] to the electron‐accepting PDIpy4. The most important thing to note in this context is that both the [Ru(CO)Pc] oxidation and the PDIpy4 reduction are rendered more difficult in 1 than in the individual building blocks. Likewise, in the excited state, strong electronic communication is the inception for a rapid charge‐transfer process in photoexcited 1. Regardless of exciting [Ru(CO)Pc] or PDIpy4, spectral characteristics of the [RuPc] radical cation (broad absorptive features from 425 to 600 nm with a maximum at 575 nm, as well as a band centered at 725 nm) and of the PDI radical anion (780 nm maximum) emerge. The correspondingly formed radical ion pair state lasts for up to several hundred picoseconds in toluene, for example. On the other hand, employing more polar solvents, such as dichloromethane, destabilizes the radical ion pair state.