bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical management of a foramen magnum tumor via a far-lateral approach using an oblique straight incision: a case series report and technique note
Authors: Bai Jie , Jian Zhi-heng , Chen Peng , Cheng Ye , Wang Ya-ming , Chen Gang , Xiao Xin-ru 
Published: June 2024

ObjectiveTo review our single-institution experience in the surgical management of foramen magnum tumors via a far-lateral approach using an oblique straight incision.MethodsFrom October 2023 to January 2024, four cases of tumors in the foramen magnum area treated at the Capital Medical University-affiliated XuanWu hospital neurosurgery department were involved in this study. All cases were managed with a far-lateral approach using an oblique straight incision. We retrospectively reviewed the clinical and imaging data, as well as the surgical strategies employed.ResultsThree cases of foramen magnum meningiomas and one case of glioma of the ventral medulla. All cases underwent a far-lateral approach using an oblique straight incision; all cases had a gross total resection, and the wounds healed well without cerebral fluid leakage or scalp hydrops. Except for one case of right foramen magnum meningioma, which had dysphagia and pneumothorax, the other cases were without any postoperative complications.ConclusionA far-lateral approach using an oblique straight incision can preserve muscle integrity and minimize subcutaneous exposure, allowing for complete anatomical reduction of muscles. This craniectomy method is simple and replicable, making it worthy of further clinical practice.
Liposomes have a direct effect on multiple myeloma: a Mendelian randomization study
Authors: Zhong Yingbin , Li Yanhao , Sun Weipeng , Xiao Mingfeng 
Published: June 2024

BackgroundMultiple myeloma (MM), a malignant disease of plasma cells originating in the bone marrow, is influenced significantly by genetic factors. Although plasma liposomes have been linked to MM, the nature of their potential causal relationship remains to be elucidated. This study aims to explore this relationship using Mendelian randomization (MR) analysis.MethodsLiposome-associated genetic instrumental variables (IVs) were identified from plasma lipidomics data of 7,174 Finnish individuals within a Genome-Wide Association Study (GWAS) pooled database. A MM pooled dataset was sourced from a GWAS meta-analysis encompassing 150,797 individuals, including 598 MM patients and 218,194 controls. These IVs underwent MR analysis, adhering to strict criteria for correlation, independence, and the exclusion of confounders. The inverse variance weighted (IVW) method, MR-Egger method, weighted median (WM) method, and simple median were utilized for MR analysis assessment, alongside Cochran’s Q test, MR-Egger intercept, MR-Pleiotropy Residual Sum and Outlier (MR-RESSO) method, and leave-one-out analysis for evaluating heterogeneity, multiplicity, and instrumental bias.ResultsThe study identified 88 significant, independent single nucleotide polymorphisms (SNPs) as IVs for MR analysis, each with an F-statistic value above 10, indicating robustness against weak instrument bias. IVW analysis revealed associations between six plasma liposome components and MM risk (p &lt; 0.05). Phosphatidylinositol (16:0_18:1) serum levels (odds ratio [OR] = 1.769, 95% confidence interval [CI]: 1.132-2.763, p = 0.012) and triacylglycerol (56:4) levels (p = 0.026, OR = 1.417, 95% CI: 1.042-1.926) were positively correlated with the risk of multiple myeloma development. Phosphatidylethanolamine (18:0_20:4) (p = 0.004, 95% CI: 0.621-0.916, OR = 0.754), phosphatidylcholine (18:2_20:4) (p = 0.004, OR = 0.680, 95% CI: 0.519-0.889), sterol ester (27:1/18:3) levels (p = 0.013, OR = 0.677, 95% CI: 0.498-0.922), and phosphatidylcholine (O-18:2_20:4) levels (OR = 0.710, 95% CI: 0.517-0.913, p = 0.033) were negatively associated with the risk of developing multiple myeloma. The Cochran’s Q test did not detect statistical method heterogeneity, nor did the MR-RESSO test or the MR-Egger intercept detect horizontal pleiotropy; leave-one-out analyses confirmed the absence of bias from individual SNPsConclusionsOur findings suggest a complex relationship between plasma liposome components and MM risk. Elevated serum levels of triacylglycerol and phosphatidylinositol are positively associated with MM risk, while certain phospholipids and sterol esters offer a protective effect. This study provides valuable insights into the clinical relevance of liposomes in the pathology of multiple myeloma.
The prevalence of polypharmacy and hyper-polypharmacy among middle-aged vs. older patients in Saudi Arabia: a cross-sectional study
Authors: Alqurain Aymen A. , Albaharnah Murtada , Al Zayer Samanah , Ameer Luma , Ghosn Sherihan , Al-Shaibi Samaher , Algoraini Marwa , Aldhafeeri Amal , Alyusuf Danah A. , Alshnbari Afnan , Alsaffar Nida , Al-Matouq Jenan , Al Khamees Mohammed , AlAlwan Bader , Alomar Fadhel A. 
Published: June 2024

IntroductionPolypharmacy, the use of multiple medications, is a growing concern among middle-aged and older patients, posing potential risks and challenges in healthcare management.AimThis study aimed to identify the prevalence of polypharmacy and hyper-polypharmacy among populations of middle-aged vs. older patients and identify its associated common comorbidities and prescribed medications in Qatif Central Hospital (QCH), Saudi Arabia.MethodsPatients aged 40 years or older who presented to an outpatient medical care clinic at QCH, Saudi Arabia, between 1 January and 31 December 2021 were included, and their comorbidities, prescribed medications, and recent clinical laboratory test results were collected. The Charlson comorbidity index (CCI) score was calculated to predict the risk of mortality. Logistic regression was used to compute the association between the prevalence of polypharmacy and patient characteristics. The results were presented as odds ratios (ORs) and 95% confidence intervals (95% CIs).ResultsA total of 14,081 patients were included; 31% of the cohort comprised older patients, and 66% of the cohort was identified with polypharmacy. The majority of the polymedicated patients were presented to an internal medicine care unit (34%). The prevalence of polypharmacy was positively associated with CCI (OR = 3.4, 95% CI 3.3–3.6), having a disease related to the musculoskeletal system (MSD) (OR = 4.2, 95% CI 3.8–4.7), and alimentary tract and metabolism (ATM) (OR = 3.8, 95% CI 3.4–4.2). Conversely, the prevalence of polypharmacy was negatively associated with age (OR = 0.9, 95% CI 0.89–0.91) and patients with cardiovascular diseases (OR = 0.6, 95% CI 0.5–0.7).ConclusionPolypharmacy is still an ongoing concern. Patients, particularly those with diseases related to MSD or ATM, should be considered for reviewing prescriptions by pharmacists to reduce the risk of adverse drug reactions and future consequences of polypharmacy.
Enhancing signal-to-noise ratio in active laser imaging under cloud and fog conditions through combined matched filtering and neural network
Authors: Cui Chengshuai , Zhang Zijing , Wang Hongyang , Zhao Yuan 
Published: June 2024

Active laser imaging utilizes time-of-flight and echo intensity measurements to generate distance and intensity images of targets. However, scattering caused by cloud and fog particles, leads to imaging quality deterioration. In this study, we introduce a novel approach for improving imaging clarity in these environments. We employed a matched filtering method that leverages the distinction between signal and noise in the time domain to preliminarily extract the signal from one-dimensional photon-counting echo data. We further denoised the data by utilizing the Long Short-Term Memory (LSTM) neural network in extracting features from extended time-series data. The proposed method displayed notable improvement in the signal-to-noise ratio (SNR), from 7.227 dB to 31.35 dB, following an analysis of experimental data collected under cloud and fog conditions. Furthermore, processing positively affected the quality of the distance image with an increase in the structural similarity (SSIM) index from 0.7883 to 0.9070. Additionally, the point-cloud images were successfully restored. These findings suggest that the integration of matched filtering and the LSTM algorithm effectively enhances beam imaging quality in the presence of cloud and fog scattering. This method has potential application in various fields, including navigation, remote sensing, and other areas susceptible to complex environmental conditions.
The indirect impact of the technostress subfactors on the satisfaction and desire to work from home
Authors: Simon Adél Csenge , Buzás Barnabás , Rosta-Filep Orsolya , Faragó Klára , Pachner Orsolya Csilla , Kiss Orhidea Edith 
Published: June 2024

IntroductionOrganizational digitalization is a phenomenon that is becoming more widespread and holistic; that is responsible for more employees being affected by digital work and working from home. While introducing remote work offers numerous economic benefits for organizations, this transition must be aligned with employees' needs rather than in an authoritarian manner. Our research aimed to investigate how sub-factors of technostress, directly and indirectly, influence the satisfaction and desire to work from home.MethodsWe conducted a cross-sectional survey with a sample of 361 office workers with at least two years of experience who have spent some time working from home. We checked our hypotheses with a path model.ResultsOur research found that techno-insecurity and techno-complexity have a minimal direct influence on the desire to work from home. However, the desire to work from home significantly decreases through various mediation pathways via the status sub-factor (which can be seen as one of the latent benefits of remote work) and through satisfaction with working from home. Our model explains 33.7% of the variance in the desire to work from home.DiscussionThis suggests that leaders have a task of great significance: to decrease the technostress employees are exposed to and to draw the attention of researchers to the fact that technostress has more complex indirect effects than previously assumed.
Trends in injury-related mortality among residents of Jiangsu Province from 2012 to 2021: an age-period-cohort analysis
Authors: Du Wencong , Wang Rong , Fan Xikang , Wu Xun , Yang Jie , Zhou Jinyi , Yu Hao 
Published: June 2024

ObjectiveWe investigated the temporal trends and examined age-, period-, and cohort-specific effects of injury-related deaths among residents in Jiangsu to provide evidence for future injury prevention.MethodsThis study included 406,936 injury deaths from the Jiangsu provincial population death registration system. The average annual percent change (AAPC) in age-standardized mortality rates (ASMRs) was analyzed using joinpoint regression. Age-period-cohort models were generated to explore the effects of age, period, and birth cohort effects on mortality risk.ResultsASMRs for all injuries (AAPC = −2.3%), road traffic accidents (AAPC = −5.3%), suicide (AAPC = −3.8%), and drowning (AAPC = −3.9%) showed a downward trend during 2012–2021(all p &lt; 0.05), while unintentional falls showed an upward trend (AAPC = 5.1%, p &lt; 0.05). From 2012 to 2021, the age-standardized mortality rates (ASMRs) for four primary types of injuries consistently exhibited higher among males compared to females, with rural regions displaying higher ASMRs than urban areas. Trends in ASMRs for road traffic accidents, drowning, and unintentional falls by sex and urban/rural areas were consistent with overall trends. Significant age, cohort, and period effects were identified in the trends of injury-related deaths for both sexes in Jiangsu. The age effect showed that the highest age effect for injury-related deaths was for the ages of 85 years and above, except for suicide, which was for the ages 80–84 years. Between 2012 and 2021, the period effect on road traffic accidents declined, while that on accidental falls increased. Initially, the period effect on suicide decreased but then rose, peaking in 2012 with a Relative Risk (RR) of 1.11 (95% CI: 1.04–1.19). Similarly, the period effect on drowning initially declined before rising, with the highest effect observed in 2013, at an RR of 1.12 (95% CI: 1.07–1.19). The highest cohort effects for road traffic accidents were observed in the 1957–1961 group, for accidental falls in the 1952–1956 group, and for both drowning and suicide in the 1927–1931 group.ConclusionThe mortality rate of unintentional falls has been increasing. Older adults are at high risk for the four leading injuries. The improvements in mortality rates can be attributed to advancements in education, urbanization, and the promulgation and implementation of laws and policies.
Diversity and compositional differences in the oral microbiome of oral squamous cell carcinoma patients and healthy controls: a scoping review
Authors: van Dijk M. C. , Petersen J. F. , Raber-Durlacher J. E. , Epstein J. B. , Laheij A. M. G. A. 
Published: June 2024

ObjectivesThe human oral microbiome may play a role in the development of oral squamous cell carcinoma. The aim of this scoping review was to examine microbial diversity and differences in the composition of the oral microbiome between OSCC patients and healthy controls.MethodsA literature search (in PubMed and Embase.com) was performed on January 9, 2023. The outcome variables used from the included studies of this review were alpha- and beta diversity and oral microbiome composition profiles for each taxonomic level (phylum-, class-, order-, genus- and species level).ResultsThirteen out of 423 studies were included in this review compromising 1,677 subjects, of which 905 (54.0%) were OSCC patients and 772 (46.0%) were healthy controls. Most studies found a higher alpha diversity in the OSCC patient group and significantly different beta diversities between OSCC patient samples and healthy control samples. Studies reported more abundant Fusobacteria (on phylum level), Fusobacterium (on genus level), Fusobacterium nucleatum, Porphyromonas endodontalis and Prevotella intermedia (on species level) in OSCC patients. The healthy control group had more abundant Actinobacteria (on phylum level), Streptococcus and Veilonella (on genus level) and Veilonella parvula (on species level) according to most studies.ConclusionsOur findings show differences in oral microbiome diversity and composition in OSCC patients. Clinical implications demand continuing study. Development of internationally accepted standard procedures for oral sample collection and oral microbiota analysis is needed for more conclusive and clinically relevant comparisons in future research.
The The Impact of Overt Strategy Instruction in EFL Classrooms on Reading and Listening Achievement
Authors: Kahveci Pınar , Tavil Zekiye Müge 
Published: June 2024

Language learning strategies may have a key role in foreign language learning because they may foster learner autonomy and motivation. Keeping the learner-centred nature of language learning strategies in mind, this study set out to understand the impact of overt listening and reading strategy instruction on learners’ listening and reading achievement. The study employed an explanatory mixed-method research design. Research instruments were reading and listening achievement tests and semi-structured interviews. The treatment involved overt listening and reading strategy instruction that lasted for four weeks. The findings revealed that overt listening and reading strategy instruction fostered learners’ reading and listening achievement. Similarly, semi-structured interviews revealed that learners were willing to transfer the strategies they learned to new learning situations and keep using these strategies in future learning situations.
الأثر الفوري للحجامة الانزلاقية على المصابين بآلام أسفل الظهر عضلية المنشأ لدى العاملين في جامعة مؤتة
Authors: القضاة محمد 
Published: June 2024

هدفت هذه الدراسة التعرف إلى الأثر الفوري للحجامة الانزلاقية كاستجابة فورية على المصابين بآلام أسفل الظهر عضلية المنشأ، وذلك وفقاً للمتغيرات الآتية (درجة حرارة الجزء الأيمن في أسفل الظهر، درجة حرارة الجزء الأيسر في أسفل الظهر، المدى الحركي للجذع إلى الأمام، المدى الحركي للجذع إلى الخلف)، وقد تم استخدام المنهج التجريبي لملائمته لطبيعة وأهداف الدراسة، وذلك على عينة تكونت من (13) من المصابين بآلام في منطقة أسفل الظهر من الدرجة الخفيفة من العاملين في جامعة مؤتة والذين يراجعون المركز الصحي، حيث تم اختيارهم بالطريقة العمدية وإخضاعهم لجلسة واحدة من الحجامة الانزلاقية ولمدة دقيقة واحدة فقط، واستخدم الباحث الاختبارات كأداة لجمع البيانات، واستخدم برنامج الرزم الإحصائي (SPSS) لتحليل النتائج وتحليل ويلكوكسون للمقارنة بين القياسات القبلية والبعدية. وأظهرت النتائج وجود فروق ذات دلالة إحصائية بين القياسين القبلي والبعدي لصالح القياس البعدي على مستوى درجة حرارة الجزء الأيمن في أسفل الظهر، درجة حرارة الجزء الأيسر في أسفل الظهر، المدى الحركي للجذع إلى الأمام، المدى الحركي للجذع إلى الخلف. وقد استنتج الباحث بأن لاستخدام الحجامة الانزلاقية لمدة دقيقة واحدة فقط أثر إيجابي فوري كاستجابة فورية على المرضى المصابين بآلام أسفل الظهر عضلي المنشأ من الدرجة البسيطة. وأوصى الباحث بإجراء المزيد من الدراسات المشابهة على عينات أكبر وبالطريقة التتبعية من أجل تحديد مدى استمرارية ذلك الأثر الفوري، كذلك وإجراؤها على حالات آلام أسفل الظهر من درجات الألم المتوسطة والحادة، كذلك وعلى آلام أسفل الظهر غير النوعي غير عضلية المنشأ.
Sintesis Nanokomposit Nata de Coco/Grafena Oksida Sebagai Adsorben Ion Logam Timbal
Authors: Lantu Gideon , Kamu Vanda Selvana , Aritonang Henry F. 
Published: June 2024

ABSTRACT
In this study, bacterial cellulose was synthesized using waste coconut water from Tetey, North Region, North Sulawesi and was inserted with graphene oxide using in-situ method. Mass variations of graphene oxide were inserted into bacterial cellulose with variations of 0.1 g, 0.2 g, and 0.3 g. The bacterial cellulose/graphene oxide nanocomposite was then used as an adsorbent for lead metal (Pb). The resulting nanocomposite was characterized using Fourier-Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscope-Energy Dispersive X-Ray (SEM-EDX), and X-Ray Diffraction (XRD). The results of these characterizations proved that bacterial cellulose/graphene oxide was formed. Adsorption test showed that nanocomposite of bacterial cellulose/graphene oxide could act as adsorbent. The results of the analysis showed that the the greater the mass of GO inserted inti bacterial cellulose, the higher the Pb adsorption percentage.
Keywords: bacterial cellulose/graphene oxide, adsorption, lead metal (Pb).

ABSTRAK
Dalam penelitian ini telah dilakukan sintesis nanokomposit nata de coco dari air kelapa yang diambil dari Tetey, Minahasa Utara, Sulawesi Utara dan diinsersi dengan grafena oksida menggunakan metode in-situ. Variasi massa grafena oksida yang diinsersi ke dalam nata de coco dengan variasi 0,1 g, 0,2 g, dan 0,3 g. Nanokomposit nata de coco/GO digunakan sebagai adsorben logam timbal (Pb). Scanning Electron Microscope-Energy Dispersive X-Ray (SEM-EDX), X-Ray Diffraction (XRD), dan Fourier-Transform Infrared Spectroscopy (FT-IR) digunakan sebagi instrumen karakterisasi nanokomposit. Hasil karakterisasi tersebut membuktikan bahwa nanokomposit nata de coco/grafena oksida telah terbentuk. Berdasarkan hasil analisis menggunakan Atomic Adsorption Spectroscopy (AAS) menunjukkan bahwa nanokomposit nata de coco/GO mampu bertindak sebagai adsorben. Hasil analisis menunjukkan bahwa nilai persentase adsorpsi semakin besar dengan bertambahnya massa GO yang diinsersi ke dalam nata de coco..
Kata kunci: nata de coco/grafena oksida, adsorpsi, logam timbal (Pb).
Desarrollo de Estrategias de Educación y Aprendizaje en México ante la Pandemia
Authors: Morales Benítez Brenda Ivonne , Morales Hernández Ramiro , Villalobos Aguayo Patricia , Ríos Oliveros Luis Amador 
Published: June 2024

La llegada de la pandemia a nivel mundial conllevo una serie de cambios en todos los ámbitos; en México se emitieron estrategias en los diferentes sectores uno de los cuales fue en la esfera educativa, lo que ocasiono innovaciones en la enseñanza sobre todo en el sector público, lo que permitió continuar con el ciclo escolar. Como parte de las estrategias encontradas fue el capacitar a los docentes para las clases a distancia que aunque algunas escuelas ya lo implementaban no así en su totalidad. La investigación se realiza a un total de 510 estudiantes de nivel medio superior, superior y posgrado en donde se encontró que en el 60% de los educandos cuenta con una familia la cual demanda recursos económicos para su manutención, el 72% de la población de la muestra tuvo afectaciones en lo que respecta al empleo sin embargo debido a las estrategias adoptadas por las instituciones en su mayoría se logro salvar el ciclo escolar pero existe una parte de la población que aunque fue mínima tuvo razones de abandono escolar derivado de las condiciones económicas.
Materiales Didácticos para la Enseñanza A Niños con Discapacidad Auditiva en el Nivel Preescolar de la Institución Educativa Lacides C. Bersal
Authors: Izquierdo Sánchez Rosa , Torres Valdelamar Lilibeth 
Published: June 2024

El presente articulo muestra el estudio realizado en la Institución Educativa Lacides C. Bersal en niños con discapacidad auditiva del grado de preescolar. Se observo detalladamente la metodología de enseñanza empleada por los docentes para estos niños y se logró identificar materiales didácticos que permitieron un mayor desarrollo integral en niños con discapacidad auditiva (DA). Ademas, se implementaron materiales didácticos idóneos para la enseñanza en niños de preescolar con DA. Es una investigación de enfoque cualitativo, ya que, mediante la observación de los niños y el entorno natural se pudieron seleccionar bajo análisis exhaustivo los materiales de mayor impacto para el desarrollo integral en niños con discapacidad. Además es una investigación acción con el fin de aportar mejores resultados a la problemática. La muestra está representada por un estudiante quien es quien tiene la discapacidad y la docente con sus métodos de enseñanza tradicionales para este niño. Los resultados muestran como el uso de materiales didácticos resulta ser una gran ayuda en la enseñanza – aprendizaje en niños con discapacidad, estos pueden generar estimulación multisensorial adecuada, la comprensión de conceptos abstractos que resultan ser difíciles de entender a niños con DA, se logra motivar y proporcionan oportunidades para la práctica activa y la consolidación de habilidades y conceptos.