bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of continuous positive airway pressure therapy on a large hemangioma complicated with obstructive sleep apnea syndrome: a case report
Authors: Antoniadou Maria , Steiropoulos Paschalis , Serasli Evangelia , Tsara Venetia 
Published: August 2010

Abstract

Introduction
Hemangiomas involving the upper airway can be an uncommon cause of obstructive sleep apnea syndrome.

Case presentation
A 26-year-old Caucasian man with a known history of a large hemangioma of his head and neck presented with sleep-disordered breathing to the sleep unit of our hospital. Severe obstructive sleep apnea syndrome was revealed on polysomnography. Nasal continuous positive airway pressure was implemented effectively, reducing daytime hypersomnolence and significantly improving sleep parameters. After three years of adherent use, the patient remains in a good condition and the hemangioma is stable.

Conclusion
Application of continuous positive airway pressure can be an effective treatment for patients with obstructive sleep apnea syndrome complicated with vascular tumors. Periodic follow-up of these patients is necessary, as little is known about the long-term effects of continuous positive airway pressure therapy.
Genome sequence of the necrotrophic plant pathogen Pythium ultimum reveals original pathogenicity mechanisms and effector repertoire
Authors: Lévesque C André , Brouwer Henk , Cano Liliana , Hamilton John P , Holt Carson , Huitema Edgar , Raffaele Sylvain , Robideau Gregg P , Thines Marco , Win Joe , Zerillo Marcelo M , Beakes Gordon W , Boore Jeffrey L , Busam Dana , Dumas Bernard , Ferriera Steve , Fuerstenberg Susan I , Gachon Claire MM , Gaulin Elodie , Govers Francine , Grenville-Briggs Laura , Horner Neil , Hostetler Jessica , Jiang Rays HY , Johnson Justin , Krajaejun Theerapong , Lin Haining , Meijer Harold JG , Moore Barry , Morris Paul , Phuntmart Vipaporn , Puiu Daniela , Shetty Jyoti , Stajich Jason E , Tripathy Sucheta , Wawra Stephan , van West Pieter , Whitty Brett R , Coutinho Pedro M , Henrissat Bernard , Martin Frank , Thomas Paul D , Tyler Brett M , De Vries Ronald P , Kamoun Sophien , Yandell Mark , Tisserat Ned , Buell C Robin 
Published: August 2010

Abstract
Background
Pythium ultimum is a ubiquitous oomycete plant pathogen responsible for a variety of diseases on a broad range of crop and ornamental species.

Results
The P. ultimum genome (42.8 Mb) encodes 15,290 genes and has extensive sequence similarity and synteny with related Phytophthora species, including the potato blight pathogen Phytophthora infestans. Whole transcriptome sequencing revealed expression of 86% of genes, with detectable differential expression of suites of genes under abiotic stress and in the presence of a host. The predicted proteome includes a large repertoire of proteins involved in plant pathogen interactions, although, surprisingly, the P. ultimum genome does not encode any classical RXLR effectors and relatively few Crinkler genes in comparison to related phytopathogenic oomycetes. A lower number of enzymes involved in carbohydrate metabolism were present compared to Phytophthora species, with the notable absence of cutinases, suggesting a significant difference in virulence mechanisms between P. ultimum and more host-specific oomycete species. Although we observed a high degree of orthology with Phytophthora genomes, there were novel features of the P. ultimum proteome, including an expansion of genes involved in proteolysis and genes unique to Pythium. We identified a small gene family of cadherins, proteins involved in cell adhesion, the first report of these in a genome outside the metazoans.

Conclusions
Access to the P. ultimum genome has revealed not only core pathogenic mechanisms within the oomycetes but also lineage-specific genes associated with the alternative virulence and lifestyles found within the pythiaceous lineages compared to the Peronosporaceae.
Impact of Type of Preadmission Sulfonylureas on Mortality and Cardiovascular Outcomes in Diabetic Patients with Acute Myocardial Infarction
Authors: Zeller Marianne , Danchin Nicolas , Simon Dominique , Vahanian Alec , Lorgis Luc , Cottin Yves , Berland Jacques , Gueret Pascal , Wyart Pascal , Deturck Régis , Tabone Xavier , Machecourt Jacques , Leclercq Florence , Drouet Elodie , Mulak Geneviève , Bataille Vincent , Cambou Jean-Pierre , Ferrieres Jean , Simon Tabassome ,   For the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction investigators
Published: August 2010

Background: The impact of antidiabetic medications on clinical outcomes in patients developing acute myocardial infarction (MI) is controversial. We sought to determine whether in-hospital outcomes in patients who were on sulfonylureas (SUs) when they developed their MIs differed from that of diabetic patients not receiving SUs and whether clinical outcomes were related to the pancreatic cells specificity of SUs.
Methods and Results: We analyzed the outcomes of the 1310 diabetic patients included in the nationwide French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction in 2005. Medications used before the acute episode were recorded. In-hospital complications were analyzed according to prior antidiabetic treatment. Mortality was lower in patients previously treated with SUs (3.9%) vs. those on other oral medications (6.4%), insulin (9.4%), or no medication (8.4%) (P = 0.014). Among SU-treated patients, in-hospital mortality was lower in patients receiving pancreatic cells-specific SUs (gliclazide or glimepiride) (2.7%), compared with glibenclamide (7.5%) (P = 0.019). Arrhythmias and ischemic complications were also less frequent in patients receiving gliclazide/glimepiride. The lower risk in patients receiving gliclazide/glimepiride vs. glibenclamide persisted after multivariate adjustment (odds ratio 0.15; 95% confidence interval 0.04–0.56) and in propensity score-matched cohorts.
Conclusion: In this nationwide registry of patients hospitalized for acute MI, no hazard was associated with the use of SUs before the acute episode. In addition, patients previously receiving gliclazide/glimepiride had improved in-hospital outcomes, compared with those on glibenclamide.
Altered Retinoid Uptake and Action Contributes to Cell Survival in Endometriosis
Authors: Pavone Mary Ellen , Reierstad Scott , Sun Hui , Milad Magdy , Bulun Serdar E. , Cheng You-Hong 
Published: August 2010

Context: Retinoic acid (RA) controls multiple biological processes via exerting opposing effects on cell survival. Retinol uptake into cells is controlled by stimulated by RA 6 (STRA6). RA is then produced from retinol in the cytosol. Partitioning of RA between the nuclear receptors RA receptor α and peroxisome-proliferator-activated receptor β/δ is regulated by cytosol-to-nuclear shuttling proteins cellular RA binding protein 2 (CRABP2) and fatty acid binding protein 5 (FABP5), which induce apoptosis or enhance survival, respectively. The roles of these mechanisms in endometrium or endometriosis remain unknown.Objective: The aim was to determine the regulation of retinoid uptake and RA action in primary stromal cells from endometrium (n = 10) or endometriosis (n = 10).Results: Progesterone receptor was necessary for high STRA6 and CRABP2 expression in endometrial stromal cells. STRA6, which was responsible for labeled retinoid uptake, was strikingly lower in endometriotic cells compared to endometrial cells. CRABP2 knockdown in endometrial cells increased survival, and FABP5 knockdown in endometriotic cells decreased survival without altering the expression of downstream nuclear retinoic acid receptor α and peroxisome-proliferator-activated receptor β/δ.Conclusions: In endometrial stromal cells, progesterone receptor up-regulates expression of STRA6 and CRABP2, which control retinol uptake and growth-suppressor actions of RA. In endometriotic stromal cells, decreased expression of these genes leads to decreased retinol uptake and dominant FABP5-mediated prosurvival activity.
Interaction Analyses of Amyloid β Peptide (1–40) with Glycosaminoglycan Model Polymers
Authors: Miura Yoshiko , Mizuno Hikaru 
Published: August 2010

Abstract
We synthesized a novel glycopolymer library with 6-sulfo-GlcNAc and glucuronic acid (GlcA) based on the structure of glycosaminoglycans. The molecular weights of the polymers were controlled via living radical polymerization. The interactions of Aβ(1–40) with glycopolymers were analyzed by inhibition activity of protein aggregation using ThT fluorescence assay, atomic force microscopy observation, and CD spectra. The inhibition activity of Aβ was much affected by the sugar structure and molecular weight of the polymer. The glycopolymers carrying 6-sulfo-GlcNAc showed inhibition activity toward Aβ aggregate, and those with 6-suflo-GlcNAc and GlcA showed the strong inhibition activity. The glycopolymer libraries yielded valuable information about Aβ aggregate with glycosaminoglycans.
Infliximab-Induced Lichen Planopilaris
Authors: Fernández-Torres Rosa , Paradela Sabela , Valbuena Luis , Fonseca Eduardo 
Published: August 2010

Objective: To report a case of lichen planopilaris in a patient treated with infliximab for longstanding refractory psoriasis. Case Summary: A 37-year-old man with recalcitrant plaque psoriasis was being treated with infliximab at a dosage of 5 mg/kg every 8 weeks, with good response. However, 11 months later the patient developed follicular keratotic papulo-pustules, perifollicular erythema, and scaling, with progressive hair toss of the frontal and parietal regions of the scalp and eyebrows. A skin biopsy from a representative lesion was consistent with the diagnosis of lichen planopilaris. Discussion: Anti-tumor necrosis factor (TNF) agents have been associated with numerous cutaneous adverse events. Lichenoid reactions are uncommon but are an emerging cutaneous adverse effect. At least 13 cases of these eruptions have been recently described. Although lichenoid reactions in patients treated with TNF-α inhibitors may be clinically very diverse, we have found no previously reported cases of lichen planopilaris induced by these agents. An objective causality assessment revealed that the adverse event was probable. Conclusions: Since anti-TNF agents are being used for a rapidly expanding number of rheumatic, digestive, and dermatologie diseases, it is expected that lichenoid eruptions and other skin toxicities are likely to be seen with increasing frequency in clinical practice.
Intravenous to Oral Conversion of Antihypertensives: A Toolkit for Guideline Development
Authors: Dasta Joseph F , Boucher Bradley A , Brophy Gretchen M , Cohen Henry , Hassan Erkan , MacLaren Robert , Muzykovsky Karina , Martin Steven J , Pass Steven E , Seybert Amy L 
Published: August 2010

Objective: To provide a toolkit of information for hospitals to use in developing intravenous to oral conversion protocols for antihypertensives. Data Sources: Articles describing intravenous to oral conversion protocols for any therapeutic category were identified in an English-language MEDLINE search (1990-April 2010) using a wide variety of MeSH terms. References from selected articles were reviewed for additional material. Study Selection and Data Extraction: Experimental and observational English-language studies and review articles that focused on oral transition of intravenous drugs were selected. Data Synthesis: Most of the literature on conversion from intravenous to oral formulations involves antimicrobials. There is considerable evidence documenting reduced costs and improved patient flow through the health-care system following implementing these protocols with drugs like antimicrobials, histamine-2 receptor antagonists, and proton pump inhibitors. Although antihypertensives have not been studied, principles and implementation strategies used for other drug classes can be applied to antihypertensives. Guidance is provided on framing the problem, issues surrounding oral absorption principles, information pertaining to oral conversion in specific disease slates, and implementation and documentation strategies. Detailed tables of oral and intravenous antihypertensives are provided. Conclusions: We recommend that hospitals consider developing protocols on conversion of intravenous to oral antihypertensives in an attempt to reduce unnecessarily prolonged intravenous therapy. Information contained in this article can be used as a toolkit to select information specific to the characteristics of individual health-care systems.
Predictors of Nonadherence to Statins: A Systematic Review and Meta-Analysis
Authors: Mann Devin M , Woodward Mark , Muntner Paul , Falzon Louise , Kronish Ian 
Published: August 2010

Background: Nonadherence to statins limits the benefits of this common drug class. Individual studies assessing predictors of nonadherence haue produced inconsistent results. Objective: To identify reliable predictors of nonadherence to statins through systematic review and meta-analysis. Methods: Multiple databases, including MEDLINE, EMBASE, and PsycINFO, were searched (from inception through February 2009) to identify studies that evaluated predictors of nonadherence to statins. Studies were selected using a priori defined criteria, and each study was reviewed by 2 authors who abstracted data on study characteristics and outcomes. Relative risks were then pooled, using an inverse-variance weighted random-effects model. Results: Twenty-two cohort studies met inclusion criteria. Age had a U-shaped association with adherence; the oldest (≥70 years) and youngest (<50 years) subjects had lower adherence than the middle-aged (50-69 years) subjects. Women and patients with lower incomes were more likely to be nonadherent than were men (odds of nonadherence 1.07; 95% CI 1.04 to 1.11) and those with higher incomes (odds of nonadherence 1.18:95% CI 1.10 to 1.28), respectively. A history of cardiovascular disease predicted better adherence to statins (odds of nonadherence 0.68; 95% CI 0.66 to 0.78). Similarly, a diagnosis of hypertension or diabetes was associated with better adherence. Although there were too few studies for quantitative pooling, increased testing of lipid levels and lower out-of-pocket costs appeared to be associated with better adherence. There was substantial (l2 range 68.7-96.3%) heterogeneity between studies across factors. Conclusions: Several sociodemographic, medical, and health-care utilization characteristics are associated with statin nonadherence. These factors may be useful guides for targeting statin adherence interventions.
Patient Misidentifications Caused by Errors in Standard Bar Code Technology
Authors: Snyder Marion L , Carter Alexis , Jenkins Karen , Fantz Corinne R 
Published: August 2010

BACKGROUND
Bar code technology has decreased transcription errors in many healthcare applications. However, we have found that linear bar code identification methods are not failsafe. In this study, we sought to identify the sources of bar code decoding errors that generated incorrect patient identifiers when bar codes were scanned for point-of-care glucose testing and to develop solutions to prevent their occurrence.

METHODS
We identified misread wristband bar codes, removed them from service, and rescanned them by using 5 different scanner models. Bar codes were reprinted in pristine condition for use as controls. We determined error rates for each bar code–scanner pair and manually calculated internal bar code data integrity checks.

RESULTS
As many as 3 incorrect patient identifiers were generated from a single bar code. Minor bar code imperfections, failure to control for bar code scanner resolution requirements, and less than optimal printed bar code orientation were confirmed as sources of these errors. Of the scanner models tested, the Roche ACCU-CHEK® glucometer had the highest error rate. The internal data integrity check system did not detect these errors.

CONCLUSIONS
Bar code–related patient misidentifications can occur. In the worst case, misidentified patient results could have been transmitted to the incorrect patient medical record. This report has profound implications not only for point-of-care testing but also for bar coded medication administration, transfusion recipient certification systems, and other areas where patient misidentifications can be life-threatening. Careful control of bar code scanning and printing equipment specifications will minimize this threat to patient safety. Ultimately, healthcare device manufacturers should adopt more robust and higher fidelity alternatives to linear bar code symbologies.
Preparing Very Loose Granular Triaxial Specimens by Ex Situ Freezing
Authors: Graham David S. , Elton David 
Published: August 2010

Abstract
Ex situ soil freezing can be used to prepare very loose cohesionless triaxial specimens that can be handled, stored, and transported. This paper describes two freezing techniques, freezing with cold air in a freezer and freezing with liquid nitrogen. These methods are used to prepare very loose saturated Ottawa sand specimens. Special equipment and techniques used for each method are described. The advantages and disadvantages of both methods and the effectiveness of the efforts to minimize disturbance due to volume changes during freezing are discussed. Properties of specimens prepared using each method are presented. The results of 16 consolidated undrained triaxial shear tests are presented. The freezing method affects the amount of volume change during freezing but does not significantly affect the effective angle of internal friction.
Laboratory Investigation of Fatigue Characteristics of Rubberized Asphalt Mixtures Containing Warm Asphalt Additives at a Low Temperature
Authors: Xiao Feipeng , Zhao Wenbin , Amirkhanian Serji N. 
Published: August 2010

Abstract
The fatigue life of an asphalt pavement is directly related to various factors of a typical warm mix asphalt (WMA) mixture. Improving the understanding of the fatigue behavior of the rubberized WMA mixtures is helpful in recycling the scrap tires and saving energy. This study explores the utilization of the conventional fatigue analysis approach in investigating the cumulative dissipated energy, stiffness, and fatigue life of rubberized asphalt concrete mixtures containing WMA additives. The fatigue beams were made with one rubber type (−40 mesh ambient crumb rubber), two aggregate sources, two WMA additives (Asphamin and Sasobit), and tested at 5°C. The test results indicated that the addition of crumb rubber and WMA additive not only reduced the mixing and compaction temperatures of rubberized asphalt mixtures offset by crumb rubber but also slightly extended the long-term performance of pavement when compared with conventional asphalt mixtures.
Souring Remediation by Field-wide Nitrate Injection in an Alberta Oil Field
Authors: Grigoryan A. , Lambo A. , Lin S. , Cornish S.L. , Jack T.R. , Voordouw G. 
Published: August 2010

Abstract
When oil is produced by water injection, sulphide formation (souring) can be stimulated. Souring is often caused by sulphate-reducing bacteria (SRB) which oxidize organic carbon (oil organics) with sulphate in the injection water to CO2 and sulphide. As a result, H2S concentrations in the produced water, oil and gas gradually increase. A consequence can be that the piping infrastructure must be redesigned from sweet to sour service. A relatively novel biotechnology aimed to remedy souring is to add nitrate to the injection water. Nitrate tracks the injection water effectively and its cost allows continuous and field-wide treatment. In a field-wide nitrate injection, the injection water (approximately 3,500 m3/day) was amended continuously with 2.4 mM (150 ppm) nitrate. Three points in the injection water system and 12 production wells were monitored by sampling every 2 to 3 weeks. The concentrations of sulphide, sulphate, nitrate, nitrite and ammonia in injection and produced waters were determined, as well as the activities of nitrate-reducing bacteria (NRB). Field-wide nitrate injection gave a 70% drop of aqueous sulphide within the first 5 weeks, after which the concentration recovered somewhat for the next 20 weeks. The activity of NRB increased throughout this period, indicating the possibility of further decreases in souring in the future.

Introduction
Microbial production of sulphide by sulphate-reducing bacteria (SRB) in oil reservoirs (i.e. souring) often occurs during secondary oil recovery processes when water is injected to maintain reservoir pressure. Souring is largely perceived to have negative effects because dissolved sulphide (HS−) and precipitated metal sulphides (e.g. FeS) are corrosive towards metal pipes and equipment. Injection of suspended metal sulphides may decrease reservoir injectivity by plugging zones near the injection wellbore, decreasing oil production. Suspended metal sulphides also stabilize oil-water emulsions preventing effective separation of produced water and oil. Hence, souring is highly undesirable from a business and operating point of view, especially when the original facilities were not designed to handle sour production. Souring gives rise to safety concerns regarding the exposure of workers in the field to released hydrogen sulphide and to complaints about odours from surface rights owners and, in urban settings, over the threat to real estate values of a sour service operation on or near residential property.
Foam Mobility Control for Surfactant Enhanced Oil Recovery
Authors: Li Robert Feng , Yan Wei , Liu Shunhua , Hirasaki George J. , Miller Clarence A. 
Published: August 2010

Summary
Foam generated in situ by surfactant-alternating-gas (SAG) injection is demonstrated as a substitute for polymer drive in the alkaline/surfactant/polymer (ASP) enhanced-oil-recovery (EOR) process. Foam is also effective in a similar process for a 266-cp crude oil, even though the system did not have enough polymer for favorable mobility control. Foam is shown to enhance sweep efficiency greatly in a layered sandpack with a 19:1 permeability ratio. Foam diverted surfactant solution from the high-permeability layer to the low-permeability layer. Ahead of the foam front, liquid in the low-permeability layer crossflowed into the high-permeability layer. A layered system with a 19:1 permeability contrast could be completely swept in 1.3 total pore volumes (TPV) with foam, while waterflood required 8 pore volumes (PV).