bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myeloablative doses of yttrium‐90‐ibritumomab tiuxetan and the risk of secondary myelodysplasia/acute myelogenous leukemia
Authors: Guidetti Anna , Carlo‐Stella Carmelo , Ruella Marco , Miceli Rosalba , Devizzi Lilli , Locatelli Silvia L. , Giacomini Arianna , Testi Adele , Buttiglieri Stefano , Risso Alessandra , Mariani Luigi , Di Nicola Massimo , Passera Roberto , Tarella Corrado , Gianni Alessandro M. 
Published: May 2011

AbstractBACKGROUND:Because the long‐term toxicity of myeloablative radioimmunotherapy remains a matter of concern, the authors evaluated the hematopoietic damage and incidence of secondary myelodysplastic syndrome and acute myelogenous leukemia (sMDS/AML) in patients who received myeloablative doses of the radiolabeled antibody yttrium‐90 (90Y)‐ibritumomab tiuxetan.METHODS:The occurrence of sMDS/AML was investigated prospectively in 53 elderly patients with non‐Hodgkin lymphoma (NHL) who underwent an autograft after high‐dose radioimmunotherapy (HD‐RIT) myeloablative conditioning with 90Y‐ibritumomab tiuxetan. Bone marrow (BM) hematopoietic progenitors and telomere length (TL) also were investigated.RESULTS:At a median follow‐up of 49 months, 4 patients developed sMDS/AML at 6 months, 12 months, 27 months, and 36 months after HD‐RIT, and the 5‐year cumulative incidence of sMDS/AML was 8.29%. A significant but transient decrease in BM granulocyte‐macrophage progenitors was observed; whereas multilineage, erythroid, and fibroblast progenitors were unaffected. A significant and persistent shortening of BM TL also was detected. A matched‐pair analysis comparing the study patients with 55 NHL patients who underwent autografts after chemotherapy‐based myeloablative conditioning demonstrated a 8.05% 5‐year cumulative incidence of sMDS/AML.CONCLUSIONS:HD‐RIT for patients with NHL was associated with 1) limited toxicity on hematopoietic progenitors, 2) accelerated TL shortening, and 3) non‐negligible incidence of sMDS/AML, which nevertheless was comparable to the incidence observed in a matched group of patients who received chemotherapy‐based conditioning. Thus, in the current series of elderly patients with NHL, the development of sMDS/AML was not influenced substantially by HD‐RIT. Cancer 2011;. © 2011 American Cancer Society.
Wet‐Chemical Synthesis of Nanoscale Iron Boride, XAFS Analysis and Crystallisation to α‐FeB
Authors: Rades Steffi , Kornowski Andreas , Weller Horst , Albert Barbara 
Published: May 2011

AbstractThe reaction of lithium tetrahydridoborate and iron bromide in high boiling ether as reaction medium produces an ultrafine, pyrophoric and magnetic precipitate. X‐ray and electron diffraction proved the product to be amorphous. According to X‐ray absorption fine structure spectroscopy (XAFS) the precipitate has FeB structure up to nearly two coordination spheres around an iron absorber atom. Transmission electron microscopy (TEM) confirms the ultrafine powder to be nanoscale. Subsequent annealing at 450 °C causes the atoms to arrange in a more distinct FeB structure, and further thermal treatment to 1050 °C extends the local structure to the α‐modification of FeB. Between 1050 °C and 1500 °C α‐FeB is transformed into β‐FeB.
Semi‐automated scoring of triple‐probe FISH in human sperm: Methods and further validation
Authors: Perry Melissa J. , Chen Xing , McAuliffe Megan E. , Maity Arnab , Deloid Glen M. 
Published: May 2011

AbstractAlthough the frequency and consequence of sperm chromosomal abnormalities are considerable, few epidemiologic studies in large samples have been conducted to investigate etiologic risk factors. This is, in part, attributable to the labor intensive demands of manual sperm fluorescence in situ hybridization (FISH) scoring. As part of an epidemiologic study investigating environmental risk factors for aneuploidy among men attending a hospital‐based fertility clinic, a semi‐automated method of slide scoring was further validated and used to estimate sex chromosome sperm disomy frequency in a large number of samples. Multiprobe FISH for chromosomes X, Y, and 18 was used to determine sex chromosome disomy in sperm nuclei. Semi‐automated scoring methods were used to quantify X disomy (sperm FISH genotype XX18), Y disomy (YY18), and XY disomy (XY18). The semi‐automated results were compared with the results from manual scoring in 10 slides. The semi‐automated method was then used to estimate sex chromosome disomy frequency in 60 men. Of 10 slides scored, significant differences between the manual and semi‐automated results were seen primarily in one slide that was of poor quality because of over swollen nuclei. Among 60 men analyzed using the semi‐automated method, median total sex chromosome disomy frequency was 1.65%, which is higher than seen among normal men but within range with reports from fertility clinic populations. These results further validate that semi‐automated methods can be used to score sperm disomy with results comparable to manual methods. This is the largest study to date to provide estimates of sex chromosome disomy among men attending fertility clinics. These methods should be replicated in larger clinic populations to arrive at stable estimates of aneuploidy frequency in men who are members of subfertile couples. © 2011 International Society for Advancement of Cytometry
Flow cytometric characterization of cerebrospinal fluid cells
Authors: de Graaf Marieke T. , de Jongste Arjen H. C. , Kraan Jaco , Boonstra Joke G. , Smitt Peter A. E. Sillevis , Gratama Jan W. 
Published: May 2011

AbstractFlow cytometry facilitates the detection of a large spectrum of cellular characteristics on a per cell basis, determination of absolute cell numbers and detection of rare events with high sensitivity and specificity. White blood cell (WBC) counts in cerebrospinal fluid (CSF) are important for the diagnosis of many neurological disorders. WBC counting and differential can be performed by microscopy, hematology analyzers, or flow cytometry. Flow cytometry of CSF is increasingly being considered as the method of choice in patients suspected of leptomeningeal localization of hematological malignancies. Additionally, in several neuroinflammatory diseases such as multiple sclerosis and paraneoplastic neurological syndromes, flow cytometry is commonly performed to obtain insight into the immunopathogenesis of these diseases. Technically, the low cellularity of CSF samples, combined with the rapidly declining WBC viability, makes CSF flow cytometry challenging. Comparison of flow cytometry with microscopic and molecular techniques shows that each technique has its own advantages and is ideally combined. We expect that increasing the number of flow cytometric parameters that can be simultaneously studied within one sample, will further refine the information on CSF cell subsets in low‐cellular CSF samples and enable to define cell populations more accurately. © 2011 International Clinical Cytometry Society
A service‐oriented taxonomical spectrum, cloudy challenges and opportunities of cloud computing
Authors: Rimal Bhaskar Prasad , Choi Eunmi 
Published: May 2011

SUMMARYCloud computing has emerged as a popular computing milieu that provides a range of delivering solutions for small to large enterprises with a flexible model that allows a computing power and storing space for the large volumetric data within minimum cost. These days, computational paradigm is shifting towards utility‐based pay‐as‐you‐go model and many discussion aside, but there remains no canonical definition of cloud computing yet. In this paper we have proposed a service‐oriented taxonomical spectrum of cloud computing, which is more focused on the service engineering perspective of cloud. Our argument behind cloud engineering is a layered structural approach ‘as a Service’ such as security as a service, fault tolerance as a service, architecture as a service. The main contribution of this paper is to identify a wide spectrum of taxonomy, aiming at a better understanding of functional as well as architectural components that could benefit from cloudification. We describe each sub‐taxonomy (architecture, core services, security, fault tolerance, management services etc.) in details. In addition, we present a comparative study of several cloud systems based on taxonomy. Moreover, it also identifies many challenges and opportunities that exist on the landscape of enterprise cloud. Copyright © 2011 John Wiley & Sons, Ltd.
Dopaminergic and noradrenergic circuit development in zebrafish
Authors: Schweitzer Jörn , Löhr Heiko , Filippi Alida , Driever Wolfgang 
Published: May 2011

AbstractDopaminergic and noradrenergic neurons constitute some of the major far projecting systems in the vertebrate brain and spinal cord that modulate the activity of circuits controlling a broad range of behaviors. Degeneration or dysfunction of dopaminergic neurons has also been linked to a number of neurological and psychiatric disorders, including Parkinson's disease. Zebrafish (Danio rerio) have emerged over the past two decades into a major genetic vertebrate model system, and thus contributed to a better understanding of developmental mechanisms controlling dopaminergic neuron specification and axonogenesis. In this review, we want to focus on conserved and dynamic aspects of the different catecholaminergic systems, which may help to evaluate the zebrafish as a model for dopaminergic and noradrenergic cellular specification and circuit function as well as biomedical aspects of catecholamine systems. © 2011 Wiley Periodicals, Inc. Develop Neurobiol 72: 256–268, 2012
Genetic dissection of the zebrafish habenula, a possible switching board for selection of behavioral strategy to cope with fear and anxiety
Authors: Okamoto Hitoshi , Agetsuma Masakazu , Aizawa Hidenori 
Published: May 2011

AbstractThe habenula is a part of an evolutionarily highly conserved conduction pathway within the limbic system that connects telencephalic nuclei to the brain stem nuclei such as interpeduncular nucleus (IPN), the ventral tegmental area (VTA), and the raphe. In mammals, the medial habenula receives inputs from the septohippocampal system, and relaying such information to the IPN. In contrast, the lateral habenula receives inputs from the ventral pallidum, a part of the basal ganglia. The physical adjunction of these two habenular nuclei suggests that the habenula may act asan intersection of the neural circuits for controlling emotion and behavior. We have recently elucidated that zebrafish has the equivalent structure as the mammalian habenula. The transgenic zebrafish, in which the neural signal transmission from the lateral subnucleus of the dorsal habenula to the dorsal IPN was selectively impaired, showed extremely enhanced levels of freezing response to presentation of the conditioned aversive stimulus. Our observation supports that the habenula may act as the multimodal switching board for controlling emotional behaviors and/or memory in experience dependent manners. © 2011 Wiley Periodicals, Inc. Develop Neurobiol 72: 386–394, 2012
The DigiBog peatland development model 2: ecohydrological simulations in 2D
Authors: Morris Paul J. , Baird Andy J. , Belyea Lisa R. 
Published: May 2011

ABSTRACTIn the first of this pair of papers we introduced the conceptual and hydrological basis of the peatland development model—DigiBog. Here we describe the submodels which simulate (i) the production of plant litter, (ii) peat decomposition, and (iii) changes in peat hydraulic conductivity due to decomposition. To illustrate how the model works, DigiBog was applied to three example situations: Bogs 1, 2, and 3. For each, the net rainfall was held constant at 30 cm year−1 and the oxic decomposition parameter kept at 0·015 year−1. The anoxic decomposition parameter varied from 5 × 10−6 (Bog 1) to 5 × 10−4 year−1 (Bog 3). Peatland development was simulated for 5000 years. For Bogs 1 and 2, plausible large peatland domes develop. Despite having a higher anoxic decomposition rate, Bog 2 grew thicker than Bog 1. This apparently counter‐intuitive result is caused by the feedback between hydraulic conductivity and degree of peat decomposition. For both Bogs 1 and 2, DigiBog also simulates transitions from wet to dry states, demarked by sudden switches from poorly decomposed to well‐decomposed peat moving upwards in the peat profile. These regime shifts result from internal peatland dynamics and not from allogenic influences, and challenge the view that peat properties are always a reflection of climate. In Bog 3, a ‘mini‐bog’ developed and persisted near the margin of the peatland; this bog can also be explained in terms of the internal feedbacks within the model. Copyright © 2011 John Wiley & Sons, Ltd.
Solvothermal Synthesis and Structural Characterisation of Metal‐Organic Frameworks with Paddle‐Wheel Zinc Carboxylate Clusters and Mixed Ligands
Authors: Li Jia , Peng Yu , Liang Hongwei , Yu Yang , Xin Bingjing , Li Guanghua , Shi Zhan , Feng Shouhua 
Published: May 2011

AbstractA series of 3D interpenetrating metal‐organic frameworks, namely, [Zn3(BPDC)3(4‐BPT)1.5]·1.5DMF [1, BPDC = biphenyl‐4,4′‐dicarboxylic acid, 4‐BPT = 4‐amino‐3,5‐bis(4‐pyridyl)‐1,2,4‐triazole, DMF = dimethylformamide], [Zn3(BPDC)3(4‐PYTZ)1.5]·1.5DMF [2, 4‐PYTZ = 3,6‐bis(pyridin‐4‐yl)‐1,2,4,5‐tetrazine], [Zn2(OBA)2(4‐PYTZ)]·2DMF [3, OBA = 4,4′‐oxybis(benzoate)], [Zn2(OBA)2(3‐PYTZ)·Zn2(OBA)2(DMF)2]·7DMF [4, 3‐PYTZ = 3,6‐bis(pyridin‐3‐yl)‐1,2,4,5‐tetrazine] and [Zn2(OBA)2(3‐BPT)]·2.5DMF [5, 3‐BPT = 4‐amino‐3,5‐bis(3‐pyridyl)‐1,2,4‐triazole] were synthesized by the reaction of Zn(NO3)2·6H2O with various dipyridyl derivatives and rigid or nonrigid aromatic dicarboxylate ligands. These five compounds were constructed by paddle‐wheel‐type coordination of ZnII pairs and mixed ligands, which can be simplified as nodes and linkers to generate a variety of topologies. Compounds 1 and 2 exhibit threefold interpenetrated 6‐connected pcu topology. The interpenetration observed in compounds 1 and 2 is a rare case of heterointerpenetration. The structure of 3 is derived from a 2D double interpenetrated rhombic grid substructure, and is an interesting example of a self‐catenated framework displaying a 6‐connected uninodal framework with a point symbol (44.610.8). Compound 4, which is derived from a crosslinked threefold interpenetrated substructure with pts topology, displays a self‐catenated 4,6‐connected binodal framework with the point symbol (42.62.72) (42.68.7.84). Compound 5 exhibits a self‐catenated 6‐connected structure with rob topology, and with the point symbol (48.66.8). Compounds 1–5 also display varied luminescence properties in the solid state.
Helicene‐Based Phosphite Ligands in Asymmetric Transition‐Metal Catalysis: Exploring Rh‐Catalyzed Hydroformylation and Ir‐Catalyzed Allylic Amination
Authors: Krausová Zuzana , Sehnal Petr , Bondzic Bojan P. , Chercheja Serghei , Eilbracht Peter , Stará Irena G. , Šaman David , Starý Ivo 
Published: May 2011

AbstractStarting from the optically pure [6]helicene‐like alcohol(P,3S)‐3‐methyl‐4‐(4‐methylphenyl)‐1,3,6,7‐tetrahydrobenzo[c]benzo[5,6]phenanthro[4,3‐e]oxepin‐14‐ol, four helical phosphites were prepared from the corresponding chlorophosphites. These ligands containing parent or substituted 1,3,2‐dioxaphospholan‐2‐yl or dibenzo[d,f][1,3,2]dioxaphosphepin‐6‐yl moieties were applied to the asymmetric hydroformylation of terminal alkenes catalyzed by Rh(acac)(CO)2 and the asymmetric allylic amination of cinnamyl‐type carbonates catalyzed by [Ir(cod)Cl]2. The helical phosphite containing the dibenzo[d,f][1,3,2]dioxaphosphepin‐6‐yl group was most successful in the asymmetric hydroformylation of styrene, leading to moderate enantiomeric excess values (up to 32 % ee), high regioselectivity in favor of the branched product, and mostly high conversion, whereas the helical ligand containing the 4,4,5,5‐tetramethyl‐1,3,2‐dioxaphospholan‐2‐yl fragment was most effective in asymmetric allylic aminations, exhibiting high enantioselectivity (up to 94 % ee), excellent regioselectivity in favor of the branched products, and good reactivity. This study represents the first use of helicene‐like ligands in asymmetric reactions, including hydroformylation and allylic amination, and the promising results indicate the potential of the helicene moieties as chiral inductors.
Chiral Primary Amine Catalyzed Asymmetric Direct Cross‐Aldol Reaction of Acetaldehyde
Authors: Hu Shenshen , Zhang Long , Li Jiuyuan , Luo Sanzhong , Cheng Jin‐Pei 
Published: May 2011

AbstractThe first primary aminocatalytic direct cross‐aldol reaction of acetaldehyde is presented. Among the various vicinal diamines screened, the L‐tert‐leucine derivative 1c in conjunction with (H4SiW12O40)0.25 was identified as the optimal catalyst; good catalytic activity (up to 99 % yield in 4 h), and high enantioselectivities (up to 92 % ee) were achieved for a range of donors, including aromatic aldehydes and isatin derivatives. Aqueous acetaldehyde solution and paraldehyde can be conveniently applied in this system.
Stereocontrolled Generation of Benzo[a]‐ and Indolo[2,3‐a]quinolizidines from (S)‐Tryptophanol and (S)‐(3,4‐Dimethoxyphenyl)alaninol‐Derived Lactams
Authors: Pérez Maria , Arioli Federica , Rigacci Gianna , Santos Maria M. M. , Gómez‐Esqué Arantxa , Escolano Carmen , Florindo Pedro , Ramos Carlos , Bosch Joan , Amat Mercedes 
Published: May 2011

AbstractThe stereochemical outcome of Pictet–Spengler cyclizations of (S)‐tryptophanol and (S)‐(3,4‐dimethoxyphenyl)alaninol‐derived lactams is discussed. When using HCl the respective trans‐H‐6/H‐12b (or H‐11b) indolo[2,3‐a]‐ or benzo[a]quinolizidines are stereoselectively formed, whereas BF3·Et2O‐promoted cyclizations lead to trans‐H‐6/H‐11b benzo[a]quinolizidines but cis‐H‐6/H‐12b indolo[2,3‐a]quinolizidines. The intermediacy of an oxazolinium salt in the latter process is demonstrated.
Alkynylboronates and ‐boramides in CoI‐ and RhI‐Catalyzed [2+2+2] Cycloadditions: Construction of Oligoaryls through Selective Suzuki Couplings
Authors: Iannazzo Laura , Vollhardt K. Peter C. , Malacria Max , Aubert Corinne , Gandon Vincent 
Published: May 2011

AbstractOligoaryls were prepared through transition‐metal‐catalyzed [2+2+2] cycloadditions of borylated alkynes, followed by Suzuki cross‐couplings with aryl halides. Ethynylboryl pinacolate took part in cobalt‐catalyzed [2+2+2] cycloadditions of all types investigated (i.e., all‐intermolecular cyclotrimerization, diyne‐yne cocyclization, and all‐intramolecular triyne cycloisomerization). The resulting platforms gave rise to linear and angular ter‐ and quateraryls after Pd‐catalyzed cross‐coupling. In addition, the first [2+2+2] cycloadditions involving alkynyl naphthaloboramides were developed. These derivatives could be cocyclized with diynes in the presence of a rhodium complex as catalyst. Because the boramide group is inactive under Suzuki coupling conditions, but can be readily deprotected to afford an active one, an iterative functionalization of a boronate‐/boramide‐substituted benzene could be achieved.
A New Indirect Electrochemical Method for Determination of Ozone in Water Using Multiwalled Carbon Nanotubes
Authors: Cesarino Ivana , Moraes Fernando C. , Machado Sergio A. S. , PassarettiFilho Juliano , Cardoso Arnaldo A. 
Published: May 2011

AbstractA new electrochemical methodology has been developed for the detection of ozone using multiwalled carbon nanotubes (MWCNT). The method presented here is based on the reaction of ozone with indigo blue dye producing anthranilic acid (ATN). The electrochemical profile of ATN on an electrode of glassy carbon (GC) modified with MWCNT showed an oxidation peak potential at 750 mV vs. Ag/AgCl. An analytical method was developed using differential pulse voltammetry (DPV) to determine ATN in a range of 50–400 nmol L−1, with a detection limit of 9.7 nmol L−1. Ozonated water samples were successfully analyzed by GC/MWCNT electrode and the recovery procedure yielded values between of 96.5 and 102.3 %.
Brain default‐mode network abnormalities in hepatic encephalopathy: A resting‐state functional MRI study
Authors: Zhang Longjiang , Qi Rongfeng , Wu Shengyong , Zhong Jianhui , Zhong Yuan , Zhang Zhiqiang , Zhang Zongjun , Lu Guangming 
Published: May 2011

AbstractMany neuroimaging investigations focus on hepatic encephalopathy (HE); however, few investigate default‐mode network (DMN) in the patients with HE and its underlying physiological relevance using resting‐state fMRI. In this study, independent component analysis was used to retrieve components representing the DMN of patients with HE (n = 14) and healthy volunteers (n = 14). Four patients were excluded because of head motion (n = 3) and the artifact from the artificial tooth (n = 1). Comparison results between the two groups revealed significantly reduced functional connectivity in the right middle frontal gyrus and left posterior cingulate cortex in the HE patients. A statistical t‐map from the comparison of venous blood ammonia levels and the z‐scores of the DMN obtained from independent component analysis was computed in the HE group, which showed negative correlation with the changes in left angular gyrus. In conclusions, resting‐state fMRI can be used to examine DMN changes in HE patients. Reduced functional connectivity in the right middle frontal gyrus and left posterior cingulate cortex consisting of the DMN and negative correlation between the functional connectivity changes in left AG and the venous blood ammonia levels support the notion of damages in functional organization of the central nervous system in HE patients. Hum Brain Mapp, 2011. © 2011 Wiley‐Liss, Inc.
Exploring commonalities across participants in the neural representation of objects
Authors: Shinkareva Svetlana V. , Malave Vicente L. , Just Marcel Adam , Mitchell Tom M. 
Published: May 2011

AbstractThe question of whether the neural encodings of objects are similar across different people is one of the key questions in cognitive neuroscience. This article examines the commonalities in the internal representation of objects, as measured with fMRI, across individuals in two complementary ways. First, we examine the commonalities in the internal representation of objects across people at the level of interobject distances, derived from whole brain fMRI data, and second, at the level of spatially localized anatomical brain regions that contain sufficient information for identification of object categories, without making the assumption that their voxel patterns are spatially matched in a common space. We examine the commonalities in internal representation of objects on 3T fMRI data collected while participants viewed line drawings depicting various tools and dwellings. This exploratory study revealed the extent to which the representation of individual concepts, and their mutual similarity, is shared across participants. Hum Brain Mapp, 2011. © 2011 Wiley‐Liss, Inc.