bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neonatal Survival After Serial Amnioinfusions for Bilateral Renal Agenesis: The Renal Anhydramnios Fetal Therapy Trial
Authors: Miller Jena L. , Baschat Ahmet A. , Rosner Mara , Blumenfeld Yair J. , Moldenhauer Julie S. , Johnson Anthony , Schenone Mauro H. , Zaretsky Michael V. , Chmait Ramen H. , Gonzalez Juan M. , Miller Russell S. , Moon-Grady Anita J. , Bendel-Stenzel Ellen , Keiser Amaris M. , Avandhani Radhika , Jelin Angie C. , Davis Jonathan M. , Warren Daniel S. , Hanley Daniel F. , Watkins Joslynn A. , Samuels Joshua , Sugarman Jeremy , Atkinson Meredith A. 
Published: June 2024

(Abstracted from JAMA 2023;330:2096–2105)
Bilateral renal agenesis is a congenital anomaly of the fetal urinary tract that results in the absence of amniotic fluid by the second trimester. This occurs in roughly 1 in 3000 births and often results in depressurization of fetal airways, impaired pulmonary development, and lethal pulmonary hypoplasia at birth.vvvvvv
Metformin Plus Insulin for Preexisting Diabetes or Gestational Diabetes in Early Pregnancy: The MOMPOD Randomized Clinical Trial
Authors: Boggess Kim A. , Valint Arielle , Refuerzo Jerrie S. , Zork Noelia , Battarbee Ashley N. , Eichelberger Kacey , Ramos Gladys A. , Olson Gayle , Durnwald Celeste , Landon Mark B. , Aagaard Kjersti M. , Wallace Kedra , Scifres Christina , Rosen Todd , Mulla Wadia , Valent Amy , Longo Sherri , Young Laura , Marquis M. Alison , Thomas Sonia , Britt Ashley , Berry Diane 
Published: June 2024

(Abstracted from JAMA 2023;330(22):2182–2190)
Preexisting type 2 diabetes in pregnant people increases the risk for adverse pregnancy outcomes, intrapartum complications, and neonatal hypoglycemia at birth. To achieve normal maternal glucose levels and optimize pregnancy outcomes, management includes maternal blood glucose monitoring, dietary management, and insulin therapy.
Vaginal Progesterone for Preventing Preterm Birth and Adverse Perinatal Outcomes in Twin Gestations: A Systematic Review and Meta-analysis
Authors: Conde-Agudelo Agustin , Romero Roberto , Rehal Anoop , Brizot Maria L. , Serra Vicente , Da Fonseca Eduardo , Cetingoz Elcin , Syngelaki Argyro , Perales Alfredo , Hassan Sonia S. , Nicolaides Kypros H. 
Published: June 2024

(Abstracted from Am J Obstet Gynecol 2023;229:599–616.e3)
Preterm birth represents a significant burden to both healthcare systems and individuals. Complications resulting from preterm birth are a leading cause of death in newborns in the first weeks of life and account for 36% of all neonatal deaths, increasing the risk of both short- and long-term complications.
Qualitative Assessment of Vulvovaginal Health Information on Social Media
Authors: Bhuiyan Julia , Addison Jessica , Hassan Areej 
Published: June 2024

(Abstracted from J Pediatr Adolesc Gynecol 2024;37:33–38)
Recent years have given way to an exponential rise in social media platforms as major hubs for dissemination and access of health information. This increase has occurred most dramatically in the social media usage of adolescents and young adults (AYAs), with more than 84% of adults aged 18–29 years and 95% of adolescents aged 13–17 years using at least one social media platform in 2021 and 2022, respectively.
Dexamethasone for Cardiac Surgery
Authors: Myles Paul S. , Dieleman Jan M. , Munting Karin E. , Forbes Andrew , Martin Catherine A. , Smith Julian A. , McGiffin David , Verheijen Lieke P. J. , Wallace Sophie , Ueoka M. , Dutton M. , Robertshaw S. , Clarris M. , Neylan A. , Hulley A. , Warwarek S. , Painter T. , Heyman K. , Falland R.-L. , Pieterse J. , Fiddes R. , Marriott A. , Dieleman J. , Cope J. , Clark-Mackay E. , van Dijk D. , Wietsma N.E. , Monteiro de Olivieira N. P. , Oey L. W. L. 
Published: June 2024

Background:
High-dose corticosteroids have been used to attenuate the inflammatory response to cardiac surgery and cardiopulmonary bypass, but patient outcome benefits remain unclear. The primary aim was to determine whether using dexamethasone was superior to not using dexamethasone to increase the number of home days in the first 30 days after cardiac surgery. Our secondary aim was to evaluate efficiency, value, and impact of the novel trial design.

Methods:
This pragmatic, international trial incorporating a prerandomized consent design favoring local practice enrolled patients undergoing cardiac surgery across seven hospitals in Australia and The Netherlands. Patients were randomly assigned to dexamethasone 1 mg/kg or not (control). The primary outcome was the number of days alive and at home up to 30 days after surgery (“home days”). Secondary outcomes included prolonged mechanical ventilation (more than 48 h), sepsis, renal failure, myocardial infarction, stroke, and death.

Results:
Of 2,093 patients assessed for eligibility, 1,951 were randomized (median age, 63 yr; 80% male). The median number of home days was 23.0 (interquartile range, 20.1 to 24.1) in the dexamethasone group and 23.1 (interquartile range, 20.1 to 24.6) in the no dexamethasone group (median difference, 0.1; 95% CI, –0.3 to 0.5; P = 0.66). The rates of prolonged mechanical ventilation (risk ratio, 0.72; 95% CI, 0.48 to 1.08), sepsis (risk ratio, 1.02; 95% CI, 0.57 to 1.82), renal failure (risk ratio, 0.94; 95% CI, 0.80 to 1.12), myocardial infarction (risk ratio, 1.20; 95% CI, 0.30 to 4.82), stroke (risk ratio, 1.06; 95% CI, 0.54 to 2.08), and death (risk ratio, 0.72; 95% CI, 0.22 to 2.35) were comparable between groups (all P > 0.10). Dexamethasone reduced intensive care unit stay (median, 29 h; interquartile range, 22 to 50 h vs. median, 43 h; interquartile range, 24 to 72 h; P = 0.004). Our novel trial design was highly efficient (89.3% enrollment).

Conclusions:
Among patients undergoing cardiac surgery, high-dose dexamethasone decreased intensive care unit stay but did not increase the number of home days after surgery.
Methylene Blue in Septic Shock: A Systematic Review and Meta-Analysis
Authors: Fernando Shannon M. , Tran Alexandre , Soliman Karim , Flynn Barbara , Oommen Thomas , Wenzhe Li , Adhikari Neill K.J. , Kanji Salmaan , Seely Andrew J.E. , Fox-Robichaud Alison E. , Wax Randy S. , Cook Deborah J. , Lamontagne François , Rochwerg Bram 
Published: June 2024

OBJECTIVES:
Although clinicians may use methylene blue (MB) in refractory septic shock, the effect of MB on patient-important outcomes remains uncertain. We conducted a systematic review and meta-analysis to investigate the benefits and harms of MB administration in patients with septic shock.

DATA SOURCES:
We searched six databases (including PubMed, Embase, and Medline) from inception to January 10, 2024.

STUDY SELECTION:
We included randomized clinical trials (RCTs) of critically ill adults comparing MB with placebo or usual care without MB administration.

DATA EXTRACTION:
Two reviewers performed screening, full-text review, and data extraction. We pooled data using a random-effects model, assessed the risk of bias using the modified Cochrane tool, and used Grading of Recommendations Assessment, Development, and Evaluation to rate certainty of effect estimates.

DATA SYNTHESIS:
We included six RCTs (302 patients). Compared with placebo or no MB administration, MB may reduce short-term mortality (RR [risk ratio] 0.66 [95% CI, 0.47–0.94], low certainty) and hospital length of stay (mean difference [MD] –2.1 d [95% CI, –1.4 to –2.8], low certainty). MB may also reduce duration of vasopressors (MD –31.1 hr [95% CI, –16.5 to –45.6], low certainty), and increase mean arterial pressure at 6 hours (MD 10.2 mm Hg [95% CI, 6.1–14.2], low certainty) compared with no MB administration. The effect of MB on serum methemoglobin concentration was uncertain (MD 0.9% [95% CI, –0.2% to 2.0%], very low certainty). We did not find any differences in adverse events.

CONCLUSIONS:
Among critically ill adults with septic shock, based on low-certainty evidence, MB may reduce short-term mortality, duration of vasopressors, and hospital length of stay, with no evidence of increased adverse events. Rigorous randomized trials evaluating the efficacy of MB in septic shock are needed.

REGISTRATION:
Center for Open Science (https://osf.io/hpy4j).
Experience of Children With Special Education Needs During COVID-19
Authors: Torres Chioma , Schaller Alexandria , Munzer Tiffany , Levitt Kimberley J. , Radesky Jenny S. 
Published: June 2024

ABSTRACT:

Objective:
The objective of this study was to examine the unique academic, behavior, and parent mental health challenges for children who qualify for a school individualized education program (IEP) during the COVID-19 pandemic.

Methods:
The authors recruited 302 parents of 5- to 10-year-old children in Michigan (February–March 2021), oversampling children with IEP supports through education-related organizations. Parents completed surveys about school format, child behavior, educational problems, IEP supports, parent stress, and depression symptoms.

Results:
Forty-seven children had an IEP, of whom 36% of parents stated their child was not receiving sufficient IEP services in 2020 to 2021. Reasons included unavailable services (41%), available services but parent unable to bring their child to school (12%), and only virtual services (47%). Compared with children without IEPs, children with IEPs had greater hyperactivity levels (p < 0.0001), more peer problems (p = 0.0003), and behavioral difficulties (p = 0.0002) and their parents had higher depression symptoms (Centers for Epidemiologic Studies Depression Scale score >21, 42.6% vs 27.3%, p = 0.03). Parents of children with IEPs reported lower rates of meeting grade level reading (51.1% vs 77.5%, p = 0.0002), math (54.6% vs 78.9%, p = 0.0006), writing expectations (35.6% vs 67.9%, p < 0.0001), and higher prevalence of medication adjustment for behavior or attention (19.5% vs 4.1%, p = 0.0007) compared with children without an IEP.

Conclusion:
Over one-third of parents of children with IEPs reported their child's learning needs were not met during COVID-19. Lack of access to services may partially explain greater behavioral difficulties and parent depression symptoms in this group. When planning supports during an interruption of in-person instruction, social-emotional needs, behavioral intervention, family support, and academic goals should be addressed.
Evaluation of Virtual Enhanced Child Adult Relationship Enhancement in Primary Care Intervention
Authors: Kiely Jenna , DePaul Emily , Rojas Stefany , Cortes SolRubi , Schilling Samantha , Dougherty Susan , Wood Joanne N. 
Published: June 2024

ABSTRACT:

Objective:
Because of COVID-19 pandemic social distancing requirements, the in-person Child Adult Relationship Enhancement in Primary Care (PriCARE) positive parenting intervention was adapted for virtual delivery. Objective was to evaluate the efficacy of the virtual PriCARE program to improve parenting capacity, decrease child behavioral problems, and decrease child maltreatment risk.

Methods:
Caregivers of children 2 to 6 years old recruited from pediatric primary care were randomized to PriCARE (n = 92) or waitlist control (n = 90). Dysfunctional parenting, positive parenting skills, child behaviors, and child maltreatment risk were measured at baseline and 2 to 3 months after intervention using the Parenting Scale (PS), Dyadic Parent-Child Interaction Coding System (DPICS), Eyberg Child Behavior Inventory (ECBI), and Child Abuse Potential Inventory (CAPI). Kruskal-Wallis test compared median change scores from baseline to follow-up by treatment arm.

Results:
Of 182 enrolled caregivers, 92% (168) were mothers and 67% (122) completed study measures at baseline and follow-up. The median decrease (improvement) in total PS score was greater in the PriCARE group compared with the control group (−0.3 [IQR 0.69] vs −0.1 [IQR 0.56], p = 0.028) as was the median decrease (improvement) in ECBI problem score (−3 [IQR 9] vs −1 [IQR 7], p = 0.045) and ECBI intensity score (−9 [IQR 21] vs 0 [IQR 25], p = 0.006). Improvements in 4 positive parenting skills measured by DPICS were greater in the PriCARE group compared with the control group (all p
< 0.003). Median decrease in CAPI abuse score did not differ significantly by study arm (p = 0.055).

Conclusion:
The PriCARE virtual adaptation demonstrated promise in promoting positive parenting and decreasing child behavior problems.
Unbiased transcriptome analysis of human cleft palate reveals evolutionally conserved molecular signatures of development: experimental study
Authors: Jo Taehee , Kim Jeonghoon , Choi Jaehoon , Kim Junhyung , Jeong Woonhyeok 
Published: June 2024

Background:
The development of the secondary palate, an essential process for hard palate formation, involves intricate cellular processes. Here, the authors examined the expression patterns of palatal fusion-associated genes in postdevelopmental human palatal tissues.

Methods:
Mucosal samples collected from the anterior fused (control; n=5) and posterior unfused regions (study; n=5) of cleft palate patients were subjected to RNA sequencing. Gene Set Enrichment Analysis (GSEA) was conducted to identify consistent changes in molecular signaling pathways using hallmark (h) gene set collections from the Molecular Signature Database v7.4. The results of RNA sequencing were validated by epithelial-mesenchymal transition (EMT) assays with suppression of target genes, including lrp6, shh, Tgfβ-3 (Bioneer), and negative control siRNA in a human fibroblast cell line (hs68).

Results:
Transcriptome profiling of the cleft mucosa demonstrated that the fully fused anterior mucosa exhibited globally upregulated EMT, Wnt β-catenin, Hedgehog, and TGF-β signaling pathways in gene set enrichment. This strongly indicates the evolutionary conserved similarities in pathways implicated in palatogenesis, as previously shown in murine models. In EMT assays with suppression of Lrp6, Shh, and TGF-β3 in human fibroblast cell lines, suppression of Lrp6 exhibited consistent suppression effects on EMT markers. This indicates a closer association with EMT compared to the other two signals.

Conclusion:
Our study highlights evolutionarily conserved molecular signatures and provides insights into the importance of the EMT pathway in palatal fusion in humans. Furthermore, intraindividual comparative analysis showed the spatial regulation of gene expression within the same organism. Further research and animal models are needed to explore the complexities of EMT-related palatal fusion.
Left ventricular posterior wall hypertrophy leads to poor prognosis of hypertrophic obstructive cardiomyopathy in children: a cohort study
Authors: Liu Shun , Hua Xiumeng , Zhao Yiqi , Mo Han , Chen Xiao , Wang Weiteng , Li Yijing , Zhao Qian , Yan Jun , Song Jiangping 
Published: June 2024

Objective:
The modified Morrow operation for hypertrophic obstructive cardiomyopathy (HOCM) in children has a favorable outcome, but some children still have a poor prognosis after the procedure. In this study, the authors aimed to investigate the application of cardiac computed tomography (CCT) to construct a three-dimensional (3D) model of the left ventricle (LV) and analyze the association between hypertrophy in different parts of the LV and poor prognosis.

Methods:
The authors retrospectively analyzed 57 children with HOCM from April 2015 to October 2022, among whom 16 underwent preoperative CCT examination. All children underwent the modified Morrow surgery in our center. The authors defined heart failure, malignant ventricular arrhythmia, and recurrent left ventricular outflow tract obstruction (LVOTO) as adverse events. The authors performed a retrospective Cox analysis and conducted genetic testing. A 3D model of the LV was built through the standard 17-segment method and analyzing the high-risk factors.

Results:
Seventeen (29.8%) had adverse events during follow-up. Multivariate Cox analysis revealed that genetic mutation (HR: 5.634, 95% CI: 1.663–19.086, P=0.005), Noonan syndrome (HR: 3.770, 95% CI: 1.245–11.419, P=0.019), preoperational systolic anterior motion (HR: 4.596, 95% CI: 1.532–13.792, P=0.007)and mid-ventricular obstruction (HR: 4.763, 95% CI: 1.538–14.754, P=0.007) were high-risk factors, suggesting that the degree of hypertrophy in the LV is associated with poor prognosis. By analyzing the CCT with a 3D model, children with poor prognosis have more hypertrophy in basal-inferior (P=0.014), mid-inferoseptal (P=0.044), and mid-inferior (P=0.017). It suggests that a more hypertrophied posterior left ventricular wall portends a worse prognosis.

Conclusion:
Even after modified Morrow surgery, the prognostic impact of genetic mutation remains significant. Moreover, the degree of hypertrophy of the posterior wall in the LV was also related to the postoperative prognosis through CCT combined with 3D technology. It provides surgeons guiding to evaluate the overall prognosis and the treatment plan before surgery.
Relationships among health promotion behaviors, patient engagement, and the nurse practitioner–patient partnership
Authors: DeCelie Irene , Sturm Bonnie 
Published: June 2024

ABSTRACT

Background:
Individuals adopting health promotion behaviors benefit from improved health and reduced risk of chronic diseases. Patient engagement and a strong provider–patient partnership may play a role in health promotion.

Purpose:
This study examined the relationships between patient engagement, the nurse practitioner–patient partnership and health promotion behaviors among adults in a primary care setting.

Methodology:
A descriptive correlational study using convenience sampling to recruit 85 participants from a nurse practitioner primary care practice. Participants completed questionnaires measuring health promotion behaviors (Health Promoting Lifestyle Profile II), the quality of the nurse practitioner–patient partnership (Patient Reactions Assessment), and a person's capacity to engage in their health care (Person Engagement Index).

Results:
Moderate to strong correlations were found among the main study variables. Multiple regression analysis found a person's capacity to engage in health care significantly predicted health promotion behaviors (R
2 = 0.362, p < .001) and explained 36.2% of the variance in health promotion behaviors.

Conclusions:
Patient engagement is a significant predictor of health promotion behaviors. The interactive care model can serve as a framework for nurse practitioners to build partnerships and facilitate patient engagement. Nurse practitioners can serve as a coach, navigator, collaborator, and trusted health care partner with their patients.

Implications:
Nurse practitioners in primary care may need to restructure the health care encounter to allow for adequate time to communicate, listen, educate, and enlist patients in the shared decision-making process. Nurse practitioners can provide the support patients need to engage in their health care as they accept greater responsibility for their health.
The efficacy of gabapentin supplementation for pain control after lumbar laminectomy and discectomy: A meta-analysis study
Authors: Li Ruhui , Li Wenbin , Yao Xiongbin 
Published: June 2024

Background:
Gabapentin supplementation may have some potential in pain control after lumbar laminectomy and discectomy, and this meta-analysis aims to explore the impact of gabapentin supplementation on postoperative pain management for lumbar laminectomy and discectomy.

Methods:
PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systematically searched, and we included randomized controlled trials assessing the effect of gabapentin supplementation on the pain control of lumbar laminectomy and discectomy.

Results:
Five randomized controlled trials were finally included in the meta-analysis. Overall, compared with control intervention for lumbar laminectomy and discectomy, gabapentin supplementation was associated with significantly lower pain scores at 2 hours (MD = −2.75; 95% CI = −3.09 to −2.41; P < .00001), pain scores at 4 hours (MD = −2.28; 95% CI = −3.36 to −1.20; P < .0001), pain scores at 24 hours (MD = −0.70; 95% CI = −0.86 to −0.55; P < .00001) and anxiety score compared to control intervention (MD = −1.32; 95% CI = −1.53 to −1.11; P < .00001), but showed no obvious impact on pain scores at 12 hours (MD = −0.58; 95% CI = −1.39 to 0.22; P = .16). In addition, gabapentin supplementation could significantly decrease the incidence of vomiting in relative to control intervention (OR = 0.31; 95% CI = 0.12–0.81; P = .02), but they had similar incidence of nausea (OR = 0.51; 95% CI = 0.15–1.73; P = .28).

Conclusions:
Gabapentin supplementation benefits to pain control after lumbar laminectomy and discectomy.
The postoperative clinical effects of utilizing 3D printed (Ti6Al4V) interbody fusion cages in posterior lumbar fusion: A retrospective cohort study
Authors: Wang Zi , Zhang Dongzhe , Zhang Zepei , Miao Jun 
Published: June 2024

Background:The research focused on the postoperative effect of using interbody fusion cage in lumbar posterior lamina decompression and interbody fusion with pedicle screw by comparing the postoperative effect of using 3D printing (Ti6Al4V) and PEEK material interbody fusion cage.Methods:Ninety-one patients with lumbar degenerative diseases from the Department of Spine Surgery of Tianjin Hospital were included in the study cohort. They were divided into 3D group (n = 39) and PEEK group (n = 52) according to the use of interbody fusion cage. The imaging data of the patients were collected and the postoperative data of the 2 groups were compared to evaluate patients’ health status and the recovery of lumbar structure and function after operation.Results:Combined with the degree of fusion, the clinical effect of 3D printing titanium alloy interbody fusion cage was comprehensively judged. At the last follow-up, the JOA score, ODI index, VAS, prolo function score, and SF-36 scale of the 2 groups showed that the clinical symptoms were better than those before operation (P< .05). The height of intervertebral disc, the area of intervertebral foramen and the physiological curvature of lumbar vertebrae increased in varying degrees after operation (P< .05). At the last follow-up, the vertebral cage fusion rates were as high as 89.13% and 90.91% in the 3D and PEEK groups, with collapse rates of 6.5% and 4.5%, respectively. There were 10 cases of cage displacement in 3D group and 7 cases of cage displacement in PEEK group. There was no significant difference between the 2 groups (P> .05).Conclusions:In conclusion, 3D printed (Ti6Al4V) interbody fusion cage can obtain good clinical effect in the surgical treatment of lumbar degenerative diseases. Posterior lumbar lamina decompression, bilateral pedicle screw fixation combined with 3D printed cage interbody fusion is excellent in rebuilding the stability of lumbar vertebrae. 3D printed interbody fusion cage can be an ideal substitute material for intervertebral bone grafting. The stable fusion time of interbody fusion cage after lumbar fusion is mostly from 3 months to half a year after operation.