bluuebunny/crossref_metadata_2025_split huggingface dataset:
De-projecting the EFThedron
Authors: Chiang Li-Yuan , Huang Yu-tin , Rodina Laurentiu , Weng He-Chen 
Published: May 2024

Abstract
The space of Wilson coefficients of EFT that can be UV completed into consistent theories was recently shown to be described analytically by a positive geometry, termed the EFThedron. However, this geometry, as well as complementary numerical methods of semi-definite programming, have so far focused on the positivity of the partial wave expansion, which allows bounding only ratios of couplings. In this paper we describe how the unitarity upper bound of the partial waves can be incorporated. This new problem can be formulated in terms of the well known L-moment problem, which we generalize and solve from a geometrical perspective. We find the non-projective generalization of the EFThedron has an infinite number of non-linear facets, which in some cases have remarkably simple descriptions. We use these results to derive bounds on single couplings, finding that the leading derivative operators are bounded by unity, when normalized by the cut-off scale and loop factors. For general operators of mass dimension 2k we find the upper bound is heavily suppressed at large k, with an 1/k fall-off.
Geometry of the spectral parameter and renormalisation of integrable sigma-models
Authors: Lacroix Sylvain , Wallberg Anders 
Published: May 2024

Abstract
In the past few years, the unifying frameworks of 4-dimensional Chern-Simons theory and affine Gaudin models have allowed for the systematic construction of a large family of integrable σ-models. These models depend on the data of a Riemann surface C (here of genus 0 or 1) and of a meromorphic 1-form ω on C, which encodes the geometry of their spectral parameter and the analytic structure of their Lax connection. The main subject of this paper is the renormalisation of these theories and in particular two conjectures describing their 1-loop RG-flow in terms of the 1-form ω. These conjectures were put forward in [1] and [2] and were proven in a variety of cases. After extending the proposal of [1] to the elliptic setup (with C of genus 1), we establish the equivalence of these two conjectures and discuss some of their applications. Moreover, we check their veracity on an explicit example, namely an integrable elliptic deformation of the Principal Chiral Model on $${{\text{SL}}}_{\mathbb{R}}\left(N\right)$$.
Remarks on integrability of $$\mathcal{N}$$ = 1 supersymmetric Ruijsenaars-Schneider three-body models
Authors: Galajinsky Anton 
Published: May 2024

Abstract
Integrability of $$\mathcal{N}$$ = 1 supersymmetric Ruijsenaars-Schneider three-body models based upon the potentials $$W\left(x\right)=\frac{2}{x}$$, $$W\left(x\right)=\frac{2}{{\text{sin}}x}$$, and $$W\left(x\right)=\frac{2}{{\text{sinh}}x}$$ is proven. The problem of constructing an algebraically resolvable set of Grassmann-odd constants of motion is reduced to finding a triplet of vectors such that all their scalar products can be expressed in terms of the original bosonic first integrals. The supersymmetric generalizations are used to build novel integrable (iso)spin extensions of the respective Ruijsenaars-Schneider three-body systems.
Tri-unification: a separate SU(5) for each fermion family
Authors: Navarro Mario Fernández , King Stephen F. , Vicente Avelino 
Published: May 2024

Abstract
In this paper we discuss SU(5)3 with cyclic symmetry as a possible grand unified theory (GUT). The basic idea of such a tri-unification is that there is a separate SU(5) for each fermion family, with the light Higgs doublet(s) arising from the third family SU(5), providing a basis for charged fermion mass hierarchies. SU(5)3 tri-unification reconciles the idea of gauge non-universality with the idea of gauge coupling unification, opening the possibility to build consistent non-universal descriptions of Nature that are valid all the way up to the scale of grand unification. As a concrete example, we propose a grand unified embedding of the tri-hypercharge model $${\text{U}}{\left(1\right)}_{Y}^{3}$$ based on an SU(5)3 framework with cyclic symmetry. We discuss a minimal tri-hypercharge example which can account for all the quark and lepton (including neutrino) masses and mixing parameters. We show that it is possible to unify the many gauge couplings into a single gauge coupling associated with the cyclic SU(5)3 gauge group, by assuming minimal multiplet splitting, together with a set of relatively light colour octet scalars. We also study proton decay in this example, and present the predictions for the proton lifetime in the dominant e+π0 channel.
Deciphering the function of the fifth class of Gα proteins: regulation of ionic homeostasis as unifying hypothesis
Authors: Abu Obaid Asmaa , Ivandic Ivan , Korsching Sigrun I. 
Published: May 2024

AbstractTrimeric G proteins transduce signals from a superfamily of receptors and each G protein controls a wide range of cellular and systemic functions. Their highly conserved alpha subunits fall in five classes, four of which have been well investigated (Gs, Gi, G12, Gq). In contrast, the function of the fifth class, Gv is completely unknown, despite its broad occurrence and evolutionary ancient origin (older than metazoans). Here we show a dynamic presence of Gv mRNA in several organs during early development of zebrafish, including the hatching gland, the pronephros and several cartilage anlagen, employing in situ hybridisation. Next, we generated a Gv frameshift mutation in zebrafish and observed distinct phenotypes such as reduced oviposition, premature hatching and craniofacial abnormalities in bone and cartilage of larval zebrafish. These phenotypes could suggest a disturbance in ionic homeostasis as a common denominator. Indeed, we find reduced levels of calcium, magnesium and potassium in the larvae and changes in expression levels of the sodium potassium pump atp1a1a.5 and the sodium/calcium exchanger ncx1b in larvae and in the adult kidney, a major osmoregulatory organ. Additionally, expression of sodium chloride cotransporter slc12a3 and the anion exchanger slc26a4 is altered in complementary ways in adult kidney. It appears that Gv may modulate ionic homeostasis in zebrafish during development and in adults. Our results constitute the first insight into the function of the fifth class of G alpha proteins.
An antifungal compound secreted by termite workers, phenylacetic acid, inhibits the growth of both termite egg-mimicking fungus and entomopathogenic fungi
Authors: Nakashima M. , Mitaka Y. , Inagaki T. , Matsuura K. 
Published: May 2024

AbstractSocial insects live in closely related family groups but face risks of intrusion and infection by pathogenic and parasitic microbes. To cope with the microbes invading their nests and feeding sites, social insects produce various types of antimicrobial substances. Subterranean termites occupy microbe-rich decaying wood and soil at high density, expanding their nest area by exploring and feeding on wood outward from the royal chamber (room for kings and queens). Although antimicrobial agents have been identified in many termite species, few studies have investigated those used by foraging workers in decaying wood under development, which is richer in microbes than the well-sterilized royal chamber and its surroundings. Here, we report that phenylacetic acid, an antifungal aromatic compound, is secreted by foraging workers of the Japanese subterranean termite Reticulitermes speratus. The compound was detected by gas chromatography–mass spectrometry analysis of ethyl acetate extracts of shelter papers infested with the workers, and antimicrobial tests demonstrated that it inhibits the germination and/or mycelial growth of the entomopathogenic fungi (Metarhizium anisopliae and Beauveria bassiana) and the termite egg-mimicking fungus Athelia termitophila. Our study provides new insights into the antimicrobial defense mechanisms of termites, including by combining different types of antimicrobial substances secreted by different castes, and thus the survival strategy of entomopathogenic and parasitic fungi in termite nests.
Correlation of microscopic tumor extension with tumor microenvironment in esophageal cancer patients
Authors: Igbo Benjamin Terfa , Jentsch Christina , Linge Annett , Plesca Ioana , Kuzay Yalçin , Löck Steffen , Kumaravadivel Mani Sankari , Doms Susanne , Stolz-Kieslich Liane , Pollack Daniela , Brückmann Sascha , Tittlbach Hannes , Weitz Jürgen , Aust Daniela , Apolle Rudi , Schmitz Marc , Troost Esther G. C. 
Published: May 2024

Abstract
Objective
In the era of image-guided adaptive radiotherapy, definition of the clinical target volume (CTV) is a challenge in various solid tumors, including esophageal cancer (EC). Many tumor microenvironmental factors, e.g., tumor cell proliferation or cancer stem cells, are hypothesized to be involved in microscopic tumor extension (MTE). Therefore, this study assessed the expression of FAK, ILK, CD44, HIF-1α, and Ki67 in EC patients after neoadjuvant radiochemotherapy followed by tumor resection (NRCHT+R) and correlated these markers with the MTE.

Methods
Formalin-fixed paraffin-embedded tumor resection specimens of ten EC patients were analyzed using multiplex immunofluorescence staining. Since gold fiducial markers had been endoscopically implanted at the proximal and distal tumor borders prior to NRCHT+R, correlation of the markers with the MTE was feasible.

Results
In tumor resection specimens of EC patients, the overall percentages of FAK+, CD44+, HIF-1α+, and Ki67+ cells were higher in tumor nests than in the tumor stroma, with the outcome for Ki67+ cells reaching statistical significance (p < 0.001). Conversely, expression of ILK+ cells was higher in tumor stroma, albeit not statistically significantly. In three patients, MTE beyond the fiducial markers was found, reaching up to 31 mm.

Conclusion
Our findings indicate that the overall expression of FAK, HIF-1α, Ki67, and CD44 was higher in tumor nests, whereas that of ILK was higher in tumor stroma. Differences in the TME between patients with residual tumor cells in the original CTV compared to those without were not found. Thus, there is insufficient evidence that the TME influences the required CTV margin on an individual patient basis.

Trial registration number and date
BO-EK-148042017 and BO-EK-177042022 on 20.06.2022, DRKS00011886, https://drks.de/search/de/trial/DRKS00011886.
Novel PHOTOPERIOD-1 gene variants associate with yield-related and root-angle traits in European bread wheat
Authors: Makhoul Manar , Schlichtermann Rica-Hanna , Ugwuanyi Samson , Weber Sven E. , Voss-Fels Kai P. , Stahl Andreas , Zetzsche Holger , Wittkop Benjamin , Snowdon Rod J. , Obermeier Christian 
Published: May 2024

Abstract
Key message
PHOTOPERIOD-1 homoeologous gene copies play a pivotal role in regulation of flowering time in wheat. Here, we show that their influence also extends to spike and shoot architecture and even impacts root development.

Abstract
The sequence diversity of three homoeologous copies of the PHOTOPERIOD-1 gene in European winter wheat was analyzed by Oxford Nanopore amplicon-based multiplex sequencing and molecular markers in a panel of 194 cultivars representing breeding progress over the past 5 decades. A strong, consistent association with an average 8% increase in grain yield was observed for the PpdA1-Hap1 haplotype across multiple environments. This haplotype was found to be linked in 51% of cultivars to the 2NS/2AS translocation, originally introduced from Aegilops ventricosa, which leads to an overestimation of its effect. However, even in cultivars without the 2NS/2AS translocation, PpdA1-Hap1 was significantly associated with increased grain yield, kernel per spike and kernel per m2 under optimal growth conditions, conferring a 4% yield advantage compared to haplotype PpdA1-Hap4. In contrast to Ppd-B1 and Ppd-D1, the Ppd-A1 gene exhibits novel structural variations and a high number of SNPs, highlighting the evolutionary changes that have occurred in this region over the course of wheat breeding history. Additionally, cultivars carrying the photoperiod-insensitive Ppd-D1a allele not only exhibit earlier heading, but also deeper roots compared to those with photoperiod-sensitive alleles under German conditions. PCR and KASP assays have been developed that can be effectively employed in marker-assisted breeding programs to introduce these favorable haplotypes.
In vivo assessment of TiO2 based wear nanoparticles in periprosthetic tissues
Authors: Gregar Filip , Gallo Jiří , Milde David , Hegrová Jitka , Kučerová Pavla , Grepl Jakub , Pluháček Tomáš 
Published: May 2024

AbstractA multimodal approach combining inductively coupled plasma mass spectrometry (ICP-MS), single-particle ICP-MS (spICP-MS), scanning electron microscopy-energy-dispersive X-ray spectroscopy (SEM-EDS) and Raman spectroscopy enabled a deeper insight into the balance between total titanium (Ti), the soluble titanium fraction and titanium dioxide based particle fraction levels in periprosthetic tissues collected from patients undergoing revision surgery. Hydrofluoric acid usage in the sample digestion allowed for complete digestion of TiO2 particles, thus enabling accurate estimation of total Ti levels. The TiO2 fraction represents 38–94% of the titanium load in the six samples where particles were detected, and the fraction is present mainly in samples from patients with aseptically loosened total hip arthroplasty. Further attention was given to this fraction determining the elemental composition, particle count, particle size and modification of TiO2. The spICP-MS analysis confirmed the presence of the TiO2-derived (nano)particles (NPs) with a 39- to 187-nm median size and particle count up to 2.3 × 1011 particles per gram of tissue. On top of that, the SEM-EDS confirmed the presence of the TiO2 nanoparticles with 230-nm median size and an anatase crystal phase was determined by Raman spectroscopy. This study presents a novel multimodal approach for TiO2 particle determination and characterization in tissue samples and is the first in vivo study of this character.
Investigation of a novel biofilm model close to the original oral microbiome
Authors: Li Pengpeng , Zhang Yuwen , Chen Dongru , Lin Huancai 
Published: May 2024

Abstract
A more optimized culture medium used in vitro to mimic the bacterial composition of original oral flora as similar as possible remains difficult at present, and the goal of this study is to develop a novel oral biofilm medium to restore the original oral microbiome. Firstly, we conducted a systematic literature review by searching PubMed and summarized the current reported culture media in vitro. Seven culture media were found. We used mixed saliva as the origin of oral species to compare the effects of the above media in culturing oral multispecies biofilms. Results indicated that among the seven media brain heart infusion containing 1% sucrose (BHIs) medium, PG medium, artificial saliva (AS) medium, and SHI medium could obviously gain large oral biofilm in vitro. The nutrients contained in different culture media may be suitable for the growth of different oral bacteria; therefore, we optimized several novel media accordingly. Notably, results of crystal violet staining showed that the biofilm cultured in our modified artificial saliva (MAS) medium had the highest amount of biofilm biomass. 16S rRNA gene sequencing showed that the operational taxonomic units (OTUs) and Shannon index of biofilm cultured in MAS medium were also the highest among all the tested media. More importantly, the 16S rRNA gene sequencing analysis indicated that the biofilm cultured in MAS medium was closer to the original saliva species. Besides, biofilm cultured by MAS was denser and produced more exopolysaccharides. MAS supported stable biofilm formation on different substrata. In conclusion, this study demonstrated a novel MAS medium that could culture oral biofilm in vitro closer to the original oral microbiome, showing a good application prospect.

Key points
• We compare the effects of different media in culturing oral biofilms
• A novel modified artificial saliva (MAS) medium was obtained in our study
• The MAS medium could culture biofilm that was closer to oral microbiome
Local environmental conditions structured discrete fish assemblages in Arctic lagoons
Authors: Laske Sarah M. , von Biela Vanessa R. , Stanek Ashley E. , Dunton Kenneth H. 
Published: May 2024

AbstractRapid changes in sea ice extent and changes in freshwater inputs from land are rapidly changing the nature of Arctic estuarine ecosystems. In the Beaufort Sea, these nearshore habitats are known for their high productivity and mix of marine resident and diadromous fishes that have great subsistence value for Indigenous communities. There is, however, a lack of information on the spatial variation among Arctic nearshore fish communities as related to environmental drivers. In summers of 2017–2019, we sampled fishes in four estuarine ecosystems to assess community composition and relate fish abundance to temperature, salinity, and wind conditions. We found fish communities were heterogeneous over larger spatial extents with rivers forming fresh estuarine plumes that supported diadromous species (e.g., broad whitefish Coregonus nasus), while lagoons with reduced freshwater input and higher salinities were associated with marine species (e.g., saffron cod Eleginus gracilis). West–East directional winds accounted for up to 66% of the community variation, indicating importance of the wind-driven balance between fresh and marine water masses. Salinity and temperature accounted for up to 54% and 37% of the variation among lagoon communities, respectively. Recent sea ice declines provide more opportunity for wind to influence oceanographic conditions and biological communities. Current subsistence practices, future commercial fishing opportunities, and on-going oil and gas activities benefit from a better understanding of current fish community distributions. This work provides important data on fish spatial distributions and community composition, providing a basis for fish community response to changing climatic conditions and anthropogenic use.
Safety and effectiveness of Evicel® fibrin sealant as an adjunct to sutured dural repair in children undergoing cranial neurosurgery
Authors: Sivakumar Gnanamurthy , Magdum Shailendra , Aquilina Kristian , Kandasamy Jothy , Josan Vivek , Ilie Bogdan , Barnett Ellie , Kocharian Richard , Pettorini Benedetta 
Published: May 2024

Abstract
Purpose
Cerebrospinal fluid (CSF) leakage is a challenging complication of intradural cranial surgery, and children are particularly at risk. The use of dural sealants confers protection in adults, but pediatric studies are scarce. We evaluated the safety and efficacy of Evicel® fibrin sealant as an adjunct to primary dural suturing in children undergoing cranial surgery.

Methods
A multicenter trial prospectively enrolled pediatric subjects (< 18 years) undergoing cranial neurosurgery who, upon completion of primary sutured dural repair, experienced CSF leakage. As agreed by the EMA Evicel® Pediatric Investigation Plan, 40 subjects were intra-operatively randomized 2:1 to Evicel® or additional sutures (‘Sutures’). Data analysis was descriptive. The efficacy endpoint was treatment success rate, with success defined as intra-operative watertight closure after provocative Valsalva maneuver (primary endpoint). Safety endpoints were postoperative CSF leakage (incisional CSF leakage, pseudomeningocele or both) and surgical site complications (secondary endpoints).

Results
Forty subjects (0.6–17 years) were randomized to Evicel® (N = 25) or Sutures (N = 15) (intention-to-treat). Intracranial tumor was the most common indication and procedures were mostly supratentorial craniotomies. Success rates were 92.0% for Evicel® and 33.3% for Sutures, with a 2.76 estimated ratio of success rates (Farrington-Manning 95% CI [1.53, 6.16]). Sensitivity analyses in per-protocol and safety sets showed similar results. Despite a higher rescue treatment rate, the frequencies of postoperative CSF leakage and wound complications were higher for Sutures than for Evicel®.

Conclusion
This small-scale prospective study shows Evicel® treatment to be safe and effective as an adjunct to primary sutured dura mater closure in a pediatric population. Compared to additional sutures, Evicel® was associated with reduced postoperative CSF leakage and surgical site complications. (Trial registration: The trial was registered as NCT02309645 and EudraCT 2013-003558-26).
Comparison of the effectiveness and efficiency of the grid and link search methods to recover scattered skeletal remains
Authors: Keyes Craig Adam 
Published: May 2024

AbstractThe grid and link search methods are used to recover scattered skeletal remains. Neither have not been compared robustly and clear guidelines for the link method have not been sufficiently developed. The study aimed to compare the effectiveness and efficiency of both methods and propose guidelines for the link method. The scattering patterns of two scavengers of forensic relevance—slender mongooses (Galerella sanguinea) and black-backed jackals (Canis mesomelas)—were recreated using four pig skeletons (Sus scrofa domesticus). Two groups (n = 6 each) were assigned a different method to recover the scattered remains. The length of the search and when each bone was located for each scatter pattern was recorded for each group and scatter pattern. A Likert scale questionnaire assessed participants’ perceptions of their assigned method. A paired t-test (p = 0.005) compared the efficiency of each method and the questionnaire answers. Both methods were effective, recovering 100% of all remains. The link method was more efficient for both scatter patterns, despite there being no statistical significance (jackal: p = 0.089; mongoose: p = 0.464). Participants indicated favorable views for both methods; however, the link method scored significantly more favorably (p = 0.01) for efficiency. Specific guidelines were developed for the use of the link method. The link method is suggested for the recovery of scattered remains in forensic contexts, especially when the scavenger, its behavior, and scattering pattern is known or suspected.