bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical validity of the nursing diagnosis risk for unstable blood glucose level in persons with type 2 diabetes mellitus: A case–control study
Authors: Oliveira Lídia R. , Amaro Josemberg P. , Moreira Rafaella P. , Lopes Rafael O. P. , Lopes Camila T. , Ferreira José E. S. M. , Cavalcante Tahissa F. 
Published: May 2024

AbstractObjectiveTo assess clinical–causal validity evidence of the nursing diagnosis, risk for unstable blood glucose level (00179), in individuals with type 2 diabetes mellitus.MethodsA case–control study was conducted in 5 primary healthcare units, involving 107 subjects with type 2 diabetes mellitus, 60 in the case group and 47 in the control group. Causality was determined by the association between sociodemographic and clinical factors, risk factors related to the nursing diagnosis, and the occurrence of unstable blood glucose level. An association was considered when the risk factor had a p‐value of <0.05 and odds ratio >1.ResultsRisk factors, such as stress, inadequate physical activity, and low adherence to therapeutic regimen, were prevalent in the sample. Time since diagnosis between 1–5 and 6–10 years, multiracial ethnicity, and the risk factor of low adherence to therapeutic regimen increased the likelihood of the outcome. Completion of high school education was identified as a protective factor.ConclusionsThe clinical validation of the nursing diagnosis, risk for unstable blood glucose level, has been successfully established, revealing a clear association between sociodemographic and clinical factors and the risk factors inherent to the nursing diagnosis.Implications for nursing practiceThe results contribute to advancing scientific knowledge related to nursing education, research, and practice and provide support for the evolution of nursing care processes for individuals with type 2 diabetes mellitus.
Hexokinase 2 nonmetabolic function‐mediated phosphorylation of IκBα enhances pancreatic ductal adenocarcinoma progression
Authors: Tong Yingying , Liu Xin , Wu Lihui , Xiang Yaoxian , Wang Jing , Cheng Yurong , Zhang Chan , Han Baojuan , Wang Li , Yan Dong 
Published: May 2024

AbstractAberrant signaling in tumor cells induces nonmetabolic functions of some metabolic enzymes in many cellular activities. As a key glycolytic enzyme, the nonmetabolic function of hexokinase 2 (HK2) plays a role in tumor immune evasion. However, whether HK2, dependent of its nonmetabolic activity, plays a role in human pancreatic ductal adenocarcinoma (PDAC) tumorigenesis remains unclear. Here, we demonstrated that HK2 acts as a protein kinase and phosphorylates IκBα at T291 in PDAC cells, activating NF‐κB, which enters the nucleus and promotes the expression of downstream targets under hypoxia. HK2 nonmetabolic activity‐promoted activation of NF‐κB promotes the proliferation, migration, and invasion of PDAC cells. These findings provide new insights into the multifaceted roles of HK2 in tumor development and underscore the potential of targeting HK2 protein kinase activity for PDAC treatment.
Psychometric evaluation of the pictorial scale of perceived movement skill competence in Chinese children: An item response theory analysis
Authors: Li Xuanxi , Su Zheng , Wang Li , Li Jing , Diao Yucui 
Published: May 2024

AbstractAimThis study aimed to investigate the psychometric characteristics of the Pictorial Scale of Perceived Movement Skill Competence (PMSC) in Chinese children, utilizing the principles of item response theory (IRT).MethodsA total of 284 children (147 boys), aged 4–10 years (Mage = 7.39, SD = 2.18), from four schools were recruited for testing, adhering to the principle of random sampling. The Rasch model was applied to evaluate the rating scale validity, local independence, scale dimensionality, person and item fit statistics, and differential item functioning (DIF).Results(1) The rating scale validity was confirmed by the monotonically increasing trend in both average item difficulty measures and Andrich thresholds. (2) However, the observation that standardized residual correlations for all items remained below 0.3 unequivocally confirmed the presence of local independence among the variables. (3) The scale's dimensions were substantiated, with Rasch measures explaining 40.6% of total variance, exceeding the 40% threshold. Additionally, the first contrast had an eigenvalue of 1.8 and explained 8.80% of the variance, both exceeding the minimum 3:1 ratio. Consequently, the unidimensionality assumption of the item was supported. (4) Person and item fit statistics indicated requisite reliability and separation, with all achieving suitable infit and outfit measures, and point‐biserial correlations exceeding 0.55. (5) Regarding gender DIF, it was observed that the majority of items did not exhibit statistically significant gender DIF effects (p > 0.05) except item 8 (Bounce a ball, t = −2.74, p < 0.01, DIF = −0.51).ConclusionRasch analysis revealed that the instrument exhibited strong scale validity among Chinese children, adhering to the Rasch model's unidimensionality and local independence principles, with robust person and item reliability and separation. All items demonstrated a good fit. Additionally, the significant gender difference in item 8 (Bounce a ball) warrants further consideration. In conclusion, PMSC is suitable for assessing the PMSC of Chinese children.
Co‐creating and implementing a novel pre‐conference event to promote equity and inclusivity among academic researchers and people who use drugs
Authors: Stowe M. J. , Hansford Louise , Halford Rachel , Wallace Jason , Lafferty Lise 
Published: May 2024

AbstractThis commentary draws on our experience organising a targeted networking event at the 10th International Conference on Health and Hepatitis in Substance Users, in Glasgow, Scotland in October 2022. The event, held the day before the conference, brought together people with lived and living experiences of drug use and early‐ and mid‐career researchers on an equitable basis. We offer reflections, focussing on how the event promoted community‐academic engagement from members of the respective groups. We provide recommendations for how conferences can organise to engage with people who use drugs—both those with lived and living experience and foster greater inclusion for all attendees.
Socioeconomic differences in use of antiseizure medication in pregnancies with maternal epilepsy: A population‐based study from Nordic universal health care systems
Authors: Leinonen Maarit K. , Igland Jannicke , Dreier Julie Werenberg , Alvestad Silje , Cohen Jacqueline M. , Gilhus Nils Erik , Gissler Mika , Sun Yuelian , Tomson Torbjörn , Zoega Helga , Vegrim Håkon M. , Christensen Jakob , Bjørk Marte‐Helene 
Published: May 2024

AbstractObjectiveResearch points to disparities in disease burden and access to medical care in epilepsy. We studied the association between socioeconomic status (SES) and antiseizure medication (ASM) use in pregnancies with maternal epilepsy.MethodsWe conducted a cross‐sectional study consisting of 21 130 pregnancies with maternal epilepsy identified from Nordic registers during 2006–2017. SES indicators included cohabitation status, migrant background, educational attainment, and household income. Main outcomes were the proportion and patterns of ASM use from 90 days before pregnancy to birth. We applied multiple imputation to handle SES variables with 2%–4% missingness. We estimated adjusted risk ratios (aRRs) and 95% confidence intervals (CIs) using modified Poisson regression with the highest SES category as reference.ResultsMothers with the highest education and the highest income quintile used ASMs least frequently (56% and 53%, respectively). We observed increased risks of ASM discontinuation prior to or during the first trimester for low SES. The risk estimates varied depending on the SES indicator from aRR = 1.27 for low income (95% CI: 1.03–1.57) to aRR = 1.66 for low education (95% CI: 1.30–2.13). Migrant background was associated with ASM initiation after the first trimester (aRR 2.17; 95% CI 1.88–2.52). Low education was associated with the use of valproate during pregnancy in monotherapy (aRR 1.70; 95% CI 1.29–2.24) and in polytherapy (aRR 2.65; 95% CI 1.66–4.21). Low education was also associated with a 37% to 39% increased risk of switching from one ASM to another depending on the ASM used. For the other SES indicators, aRRs of switching varied from 1.16 (foreign origin; 95% CI 1.08–1.26) to 1.26 (not married or cohabiting; 95% CI 1.17–1.36).SignificanceLow SES was associated with riskier patterns of ASM use: discontinuation, late initiation, and switching during pregnancy. These findings may reflect unplanned pregnancies, disparities in access to preconception counseling, and suboptimal care.
Exploring morphometric transformations in temperature‐sensitive NiTi instruments alongside real‐time intracanal temperature dynamics
Authors: Atmeh Amre R. , Al Omari Taher , AlQifari Abdullah F. , Jamleh Ahmed 
Published: May 2024

AbstractAimThis study was twofold: (i) it aimed to investigate the morphometric changes of three temperature‐sensitive nickel–titanium (NiTi) instruments at different temperatures, and (ii) to conduct an in vivo real‐time analysis of intracanal temperature changes.MethodsChanges in the shape and length of XP‐Endo Shaper, XP‐Endo Finisher, and XP‐Endo Finisher‐R were evaluated in real time whilst heated in a temperature‐controlled water bath from 22 to 45°C. Instruments were fixed to a laminated water‐resistant 1 mm graph paper attached to a stone block. Instruments were imaged whilst subjected to increasing temperature using a digital camera attached to an operating microscope. From recorded videos, still frames were extracted at 10‐s intervals and changes in the length and shape of each instrument were measured and changes were plotted against time. Moreover, the intracanal temperature of distal roots of lower molars was measured in vivo for patients attending the clinic for non‐surgical root canal treatments. The temperature was measured using a K‐type thermocouple probe inserted into the mid‐root level after irrigating the canal with a solution set at room temperature (22°C) or heated to 45°C. The intraoral and intracanal temperatures were recorded using a video camera for 180 s at 5‐s intervals to plot the change in the intraoral and intracanal temperature, after both irrigation solution temperatures, with time.ResultsThe shape transformation of XP‐Endo Shaper began at 31.5 ± 2.0°C and reached its optimal transformation at 35.1 ± 1.0°C. For the Finisher and Finisher‐R, shape transformations began at 29.2 ± 1.9 and 26.9 ± 2.2°C reaching the optimal transformation at 33.9 ± 1.4 and 32.7 ± 1.7°C, respectively. The average decreases in lengths of XP‐Endo Shaper, Finisher, and Finisher‐R after full transformation were 0.43 ± 0.23, 1.07 ± 0.22, and 1.15 ± 0.22 mm, respectively. The intracanal temperature reached 32.9 ± 0.8 and 33.2 ± 1.0°C after 3 min of application of irrigation solutions set at 22 or 45°C, respectively.ConclusionThe tested instruments exhibited diverse changes in their shapes and lengths at varying temperatures. Despite the temperature of the irrigation solution, the intracanal temperature consistently remained lower than the intracanal temperature once equilibrium was reached. This highlights the importance of considering the temperature of irrigation solution during in vitro testing of endodontic instruments.
Insights into the digestion of chestnut (Castanea sativa) shells bioactive extracts—ultrasound vs. microwave‐assisted extraction
Authors: Pinto Diana , Moreira Manuela M. , Vallverdú‐Queralt Anna , Delerue‐Matos Cristina , Rodrigues Francisca 
Published: May 2024

SummaryIn the current study, polyphenols were extracted from chestnut (Castanea sativa) shells (CSS) by two eco‐friendly techniques, namely microwave‐assisted extraction (MAE) and ultrasound‐assisted extraction (UAE). The bioaccessibility, phenolic composition and bioactivity of CSS extracts were explored upon in vitro gastrointestinal digestion considering a future nutraceutical use. The phenolic and flavonoid concentrations, bioaccessibility and antioxidant/antiradical properties of both extracts decreased during digestion. The bioaccessibility was 25% and 26%, respectively, for UAE and MAE extracts. The phenolic profile demonstrated that gallic acid, caftaric acid and catechin were the most bioaccessible compounds for both extraction techniques. The CSS extracts unveiled notable radicals scavenging efficiency, particularly against HOCl (18.32–75.44% inhibition) and ONOO− (16.78–86.11% inhibition), as well as hypoglycaemic (6.95–17.99% α‐amylase inhibition) and neuroprotective (16.44–54.66% AChE inhibition) properties upon digestion. Considering the undigested extracts, the UAE extract revealed better results than the MAE extract. Oppositely, among digested fractions the MAE digests disclosed the most promising outcomes. The remarkable contribution of phenolic compounds to the bioactivity of CSS extracts after in vitro digestion was proved by heatmap correlations, indicating that their pro‐healthy properties were modified after gastrointestinal digestion, being ascribed to the distinct phenolic composition. This study evaluates, for the first time, the impact of in vitro gastrointestinal digestion on the bioaccessibility and bioactivity of phenolics‐rich CSS extracts prepared by UAE and MAE.
Décrypter l'attrait du télétravail pour les salariés: une expérience d'enquête factorielle
Authors: MOENS Eline , VERHOFSTADT Elsy , VAN OOTEGEM Luc , BAERT Stijn 
Published: May 2024

RésuméCet article analyse l'attrait du télétravail par le biais d'une expérience d'enquête factorielle dans laquelle les salariés évaluent des offres d'emploi présentant des caractéristiques divergentes, incluant une large variation dans la possibilité de télétravailler. La relation entre la possibilité de télétravailler et l'attrait de l'emploi s'avère approximativement linéaire: 10 points de pourcentage supplémentaires d'heures de télétravail entraînent une augmentation de 2,2 points de pourcentage de l'attrait et, par conséquent, la volonté de renoncer à une augmentation de salaire de 2,2 points de pourcentage dans le nouvel emploi. La conception expérimentale permet également d’étudier de manière structurée et approfondie les mécanismes sous‐jacents et les modérateurs de cette relation.
Experimento de encuesta factorial sobre el atractivo del teletrabajo para los empleados en Flandes
Authors: MOENS Eline , VERHOFSTADT Elsy , VAN OOTEGEM Luc , BAERT Stijn 
Published: May 2024

ResumenEn este artículo se analiza el atractivo del teletrabajo mediante un experimento de encuesta factorial a empleados que evalúan ofertas de empleo de características divergentes, con una amplia variación en cuanto a la posibilidad de teletrabajar. La relación entre esta posibilidad y el atractivo del empleo resulta ser aproximadamente lineal: una posibilidad 10 puntos porcentuales mayor de teletrabajar aumenta el atractivo del empleo en 2,2 puntos porcentuales y suscita una disposición a renunciar a 2,2 puntos porcentuales de aumento salarial en el nuevo puesto. El diseño experimental también permite investigar de forma estructurada y exhaustiva los mecanismos subyacentes y los moderadores de esta relación.
Synthesis and characterization of mullite‐type Sn(Cr1−xVx)BO4: Structural, vibrational, magnetic, and thermal properties
Authors: Wittmann Sarah , Murshed M. Mangir , Schumacher Lars , Koldemir Aylin , Pöttgen Rainer , Gesing Thorsten M. 
Published: May 2024

AbstractThe susceptibility of either oxidation into Sn(IV) or disproportionation into Sn(IV) and Sn(0) limits the study of metal tin‐(II)‐borate ceramics. We report mullite‐type SnCrBO4 and SnVBO4 synthesized in sealed quartz tubes by conventional solid‐state method. X‐ray powder diffraction data Rietveld refinements confirm that both compounds are isostructural to PbMBO4 phases for M = Al, Ga, Cr, Mn, and Fe. The end‐members show a complete miscibility within the Sn(Cr1−xVx)BO4 solid solution. Both the microstructural (average crystallite size, microstrain, and degree of crystallinity) and crystal structural (metric parameters, bond lengths, polyhedral volume, and polyhedral distortion) parameters are observed with respect to the compositional x‐value. The stereochemical activity of the 5 s2 lone electron pairs of Sn2+ cations has been measured by using the Wang–Liebau eccentricity parameter. The structural features are complemented by 119Sn Mössbauer, Raman, and Fourier‐transformed infrared spectroscopy. The 119Sn Mössbauer isomer shifts and the quadrupole splitting values confirm the SnO4 coordination and an Sn(II) valence state. The electronic band gap has been calculated from the UV/Vis diffuse reflectance spectra, which slightly increases with successive decrease of the cationic radius from V to Cr. Temperature‐dependent inverse DC magnetic susceptibility suggests that SnCrBO4 and SnVBO4 are antiferromagnetic and ferromagnetic (FM) with a Néel temperature of 17.2(1) K and a Curie temperature of 29.8(1) K, respectively. Alike the end‐member SnVBO4, Sn(Cr0.5V0.5)BO4 is also found to be a rare FM insulator. The thermal stability decreases with increasing vanadium content in the solid solution.
Integrating single‐cell and multi‐omic approaches reveals Euphorbiae Humifusae Herba‐dependent mitochondrial dysfunction in non‐small‐cell lung cancer
Authors: Zhang Chengcheng , Zhao Xiaoxue , Li Feng , Qin Jingru , Yang Lu , Yin Qianqian , Liu Yiyi , Zhu Zhiyao , Zhang Fei , Wang Zhongqi , Liang Haibin 
Published: May 2024

AbstractEuphorbiae Humifusae Herba (EHH) is a pivotal therapeutic agent with diverse pharmacological effects. However, a substantial gap exists in understanding its pharmacological properties and anti‐tumour mechanisms. This study aimed to address this gap by exploring EHH's pharmacological properties, identifying NSCLC therapy‐associated protein targets, and elucidating how EHH induces mitochondrial disruption in NSCLC cells, offering insights into novel NSCLC treatment strategies. String database was utilized to explore protein–protein interactions. Subsequently, single‐cell analysis and multi‐omics further unveiled the impact of EHH‐targeted genes on the immune microenvironment of NSCLC, as well as their influence on immunotherapeutic responses. Finally, both in vivo and in vitro experiments elucidated the anti‐tumour mechanisms of EHH, specifically through the assessment of mitochondrial ROS levels and alterations in mitochondrial membrane potential. EHH exerts its influence through engagement with a cluster of 10 genes, including the apoptotic gene CASP3. This regulatory impact on the immune milieu within NSCLC holds promise as an indicator for predicting responses to immunotherapy. Besides, EHH demonstrated the capability to induce mitochondrial ROS generation and perturbations in mitochondrial membrane potential in NSCLC cells, ultimately leading to mitochondrial dysfunction and consequent apoptosis of tumour cells. EHH induces mitochondrial disruption in NSCLC cells, leading to cell apoptosis to inhibit the progress of NSCLC.
Unraveling CCL20's role by regulating Th17 cell chemotaxis in experimental autoimmune prostatitis
Authors: Zhang Cheng , Xu Shun , Hu Rui‐Jie , Liu Xian‐Hong , Yue Shao‐Yu , Li Xiao‐Ling , Dai Bang‐Shun , Liang Chao‐Zhao , Zhan Chang‐Sheng 
Published: May 2024

AbstractChronic prostatitis and chronic pelvic pain syndrome (CP/CPPS), a prevalent urological ailment, exerts a profound influence upon the well‐being of the males. Autoimmunity driven by Th17 cells has been postulated as a potential factor in CP/CPPS pathogenesis. Nonetheless, elucidating the precise mechanisms governing Th17 cell recruitment to the prostate, triggering inflammation, remained an urgent inquiry. This study illuminated that CCL20 played a pivotal role in attracting Th17 cells to the prostate, thereby contributing to prostatitis development. Furthermore, it identified prostate stromal cells and immune cells as likely sources of CCL20. Additionally, this research unveiled that IL‐17A, released by Th17 cells, could stimulate macrophages to produce CCL20 through the NF‐κB/MAPK/PI3K pathway. The interplay between IL‐17A and CCL20 establishes a positive feedback loop, which might serve as a critical mechanism underpinning the development of chronic prostatitis, thus adding complexity to its treatment challenges.
Effects of 12 crops associated with plantain on arthropods trophic groups and Cosmopolites sordidus abundance
Authors: Pugeaux Pauline , Dépigny Sylvain , Carval Dominique , Fansi Gabriel , Tixier Philippe 
Published: May 2024

AbstractThe control of pests and diseases is one of the main challenges of sustainable agriculture. Plantains, with an annual production of nearly 12 million tons, are a significant staple food crop in West and Central Africa, as well as in Central America. Cosmopolites sordidus is the major pests for plantains and is present in all production areas. This study assessed how the traits and associated agricultural practices of 12 crops, usually associated with plantains in Cameroun, affected the arthropods trophic network and C. sordidus abundance. The abundance and the diversity of arthropods in experimental plots associating plantains with each of the 12 tested crops were measured. Each associated crop was described by a unique profile of traits and agricultural practices. This ‘trait’ approach allowed linking the plant characteristics to the abundance of arthropods from different trophic groups. Structural equation modelling was used to analyse the interactions between associated crops traits, their associated agricultural practices and the abundance of main trophic groups. The highest abundance of C. sordidus was observed in plots with Ananas comosus and Xanthosoma sagittifolium as associated crops. These plots also had the lowest abundance of omnivores and predators. In contrast, plots with the lowest abundance of C. sordidus were those with weeds and Vigna unguiculata, where more omnivores and predators were observed. Grouping associated crops by their traits and agricultural practices allowed for drawing conclusions on a wider range than the set of plants tested. For instance, this study showed that plants from the higher strata tend to decrease ground‐dwelling predators. The ideal crop traits and agricultural practices to maximize the regulation of C. sordidus should not be obtained by a single species of crop but rather by a community of associated crops.
Grower assessment of profitability impact from Brown Marmorated Stink Bug, Halyomorpha halys (Stål), the value of management information sources, and use of potential management practices
Authors: Regmi Arun , Neupane Kripa , Harper Jayson 
Published: May 2024

AbstractAn online survey was conducted from June 2018 to March 2021 to elicit information from commercial farmers and growers on the economic impact of the Brown Marmorated Stink Bug (BMSB) (Halyomorpha halys (Stål)) on agriculture and their attitudes towards adopting various alternative management practices, including use of Trissolcus japonicus as a biocontrol agent. Most respondents reported that BMSB reduced the profitability of their operation, with the largest impacts coming from reduced quality and increased spray cost. Improved monitoring techniques and natural enemies have the greatest probability to be used to manage BMSB, while tactics like attract and kill, border sprays, repellents, trap crops and netting were less likely to be adopted. Further analysis using ordered logistic and tobit regression models shows that the factors that influence potential adoption vary significantly for each management practice. This suggests that adoption efforts for alternate management practices should focus on the attributes of specific commodity groups and targeted educational programmes may be required to overcome the resistance of growers using conventional growing practices. Several variables have a consistent impact on the respondent's willingness to pay for a T. japonicus‐based biocontrol including being a commercial producer (positive impact), use of conventional growing practices (negative) and increased concern about the impact of BMSB (positive).