bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accuracy of FreeStyle Libre flash glucose monitoring in patients with type 2 diabetes who migrated from highlands to plains
Authors: Sun Zeng-Mei , Du Yuan-Ze , Wang Su-Yuan , Sun Shu-Yao , Ye Yan , Sun Xue-Ping , Li Ming-Xia , He Hua , Long Wun-Chun , Zhang Cheng-Hui , Yao Xuan-Yu , Fan Wu-Yi , Wang Ling , Wu Yun-Hong 
Published: June 2024

BACKGROUND
The FreeStyle Libre flash glucose monitoring (FGM) system entered the Chinese market in 2017 to complement the self-monitoring of blood glucose. Due to its increased usage in clinics, the number of studies investigating its accuracy has increased. However, its accuracy has not been investigated in highland popu-lations in China.
AIM
To evaluate measurements recorded using the FreeStyle Libre FGM system compared with capillary blood glucose measured using the enzyme electrode method in patients with type 2 diabetes (T2D) who had migrated within 3 mo from highlands to plains.
METHODS
Overall, 68 patients with T2D, selected from those who had recently migrated from highlands to plains (within 3 mo), were hospitalized at the Department of Endocrinology from August to October 2017 and underwent continuous glucose monitoring (CGM) with the FreeStyle Libre FGM system for 14 d. Throughout the study period, fingertip capillary blood glucose was measured daily using the enzyme electrode method (Super GL, China), and blood glucose levels were read from the scanning probe during fasting and 2 h after all three meals. Moreover, the time interval between reading the data from the scanning probe and collecting fingertip capillary blood was controlled to < 5 min. The accuracy of the FGM system was evaluated according to the CGM guidelines. Subsequently, the factors influencing the mean absolute relative difference (MARD) of this system were analyzed by a multiple linear regression method.
RESULTS
Pearson’s correlation analysis showed that the fingertip and scanned glucose levels were positively correlated (R = 0.86, P = 0.00). The aggregated MARD of scanned glucose was 14.28 ± 13.40%. Parker's error analysis showed that 99.30% of the data pairs were located in areas A and B. According to the probe wear time of the FreeStyle Libre FGM system, MARD1 d and MARD2–14 d were 16.55% and 14.35%, respectively (t = 1.23, P = 0.22). Multiple stepwise regression analysis showed that MARD did not correlate with blood glucose when the largest amplitude of glycemic excursion (LAGE) was < 5.80 mmol/L but negatively correlated with blood glucose when the LAGE was ≥ 5.80 mmol/L.
CONCLUSION
The FreeStyle Libre FGM system has good accuracy in patients with T2D who had recently migrated from highlands to plains. This system might be ideal for avoiding the effects of high hematocrit on blood glucose monitoring in populations that recently migrated to plains. MARD is mainly influenced by glucose levels and fluctuations, and the accuracy of the system is higher when the blood glucose fluctuation is small. In case of higher blood glucose level fluctuations, deviation in the scanned glucose levels is the highest at extremely low blood glucose levels.
Heyingwuzi formulation alleviates diabetic retinopathy by promoting mitophagy via the HIF-1α/BNIP3/NIX axis
Authors: Wu Jia-Jun , Zhang Shu-Yan , Mu Lin , Dong Zhi-Guo , Zhang Yin-Jian 
Published: June 2024

BACKGROUND
Diabetic retinopathy (DR) is the primary cause of visual problems in patients with diabetes. The Heyingwuzi formulation (HYWZF) is effective against DR.
AIM
To determine the HYWZF prevention mechanisms, especially those underlying mitophagy.
METHODS
Human retinal capillary endothelial cells (HRCECs) were treated with high glucose (hg), HYWZF serum, PX-478, or Mdivi-1 in vitro . Then, cell counting kit-8, transwell, and tube formation assays were used to evaluate HRCEC proliferation, invasion, and tube formation, respectively. Transmission electron microscopy was used to assess mitochondrial morphology, and Western blotting was used to determine the protein levels. Flow cytometry was used to assess cell apoptosis, reactive oxygen species (ROS) production, and mitochondrial membrane potential. Moreover, C57BL/6 mice were established in vivo using streptozotocin and treated with HYWZF for four weeks. Blood glucose levels and body weight were monitored continuously. Changes in retinal characteristics were evaluated using hematoxylin and eosin, tar violet, and periodic acid-Schiff staining. Protein levels in retinal tissues were determined via Western blotting, immunohistochemistry, and immunostaining.
RESULTS
HYWZF inhibited excessive ROS production, apoptosis, tube formation, and invasion in hg-induced HRCECs via mitochondrial autophagy in vitro . It increased the mRNA expression levels of BCL2-interacting protein 3 (BNIP3 ), FUN14 domain-containing 1, BNIP3-like (BNIP3L , also known as NIX ), PARKIN , PTEN-induced kinase 1, and hypoxia-inducible factor (HIF )-1α . Moreover, it downregulated the protein levels of vascular endothelial cell growth factor and increased the light chain 3-II/I ratio. However, PX-478 and Mdivi-1 reversed these effects. Additionally, PX-478 and Mdivi-1 rescued the effects of HYWZF by decreasing oxidative stress and apoptosis and increasing mitophagy. HYWZF intervention improved the symptoms of diabetes, tissue damage, number of acellular capillaries, and oxidative stress in vivo . Furthermore, in vivo experiments confirmed the results of in vitro experiments.
CONCLUSION
HYWZF alleviated DR and associated damage by promoting mitophagy via the HIF-1α/BNIP3/NIX axis.
Effects of exercise training on glucose metabolism indicators and inflammatory markers in obese children and adolescents: A meta-analysis
Authors: Li Le-Yang , Li Song-Mei , Pang Bo-Xian , Wei Jun-Ping , Wang Qiu-Hong 
Published: June 2024

BACKGROUND
Obesity in children and adolescents is a serious problem, and the efficacy of exercise therapy for these patients is controversial.
AIM
To assess the efficacy of exercise training on overweight and obese children based on glucose metabolism indicators and inflammatory markers.
METHODS
The PubMed, Web of Science, and Embase databases were searched for randomized controlled trials related to exercise training and obese children until October 2023. The meta-analysis was conducted using RevMan 5.3 software to evaluate the efficacy of exercise therapy on glucose metabolism indicators and inflammatory markers in obese children.
RESULTS
In total, 1010 patients from 28 studies were included. Exercise therapy reduced the levels of fasting blood glucose (FBG) [standardized mean difference (SMD): -0.78; 95% confidence interval (CI): -1.24 to -0.32, P = 0.0008], fasting insulin (FINS) (SMD: -1.55; 95%CI: -2.12 to -0.98, P < 0.00001), homeostatic model assessment for insulin resistance (HOMA-IR) (SMD: -1.58; 95%CI: -2.20 to -0.97, P < 0.00001), interleukin-6 (IL-6) (SMD: -1.31; 95%CI: -2.07 to -0.55, P = 0.0007), C-reactive protein (CRP) (SMD: -0.64; 95%CI: -1.21 to -0.08, P = 0.03), and leptin (SMD: -3.43; 95%CI: -5.82 to -1.05, P = 0.005) in overweight and obese children. Exercise training increased adiponectin levels (SMD: 1.24; 95%CI: 0.30 to 2.18, P = 0.01) but did not improve tumor necrosis factor-alpha (TNF-α) levels (SMD: -0.80; 95%CI: -1.77 to 0.18, P = 0.11).
CONCLUSION
In summary, exercise therapy improves glucose metabolism by reducing levels of FBG, FINS, HOMA-IR, as well as improves inflammatory status by reducing levels of IL-6, CRP, leptin, and increasing levels of adiponectin in overweight and obese children. There was no statistically significant effect between exercise training and levels of TNF-α. Additional long-term trials should be conducted to explore this therapeutic perspective and confirm these results.
Principles of effective management of a creative team
Authors: Горбунов В.М. , Сайтбагина Л.А. 
Published: June 2024

В статье дано определение креативной деятельности сотрудников, выделены основные ее особенности. Рассмотрены основные принципы управления креативной командой – уникальность каждого сотрудника, персонализация его условий труда и карьерного пути, гибкость процесса постановки задач и общения с руководителем, открытость общения с другими сотрудниками. Представлены примеры факторов, повышающих эффективность креативной деятельности.
This article defines the creative activity of employees, highlights its main features. The basic principles of managing a creative team are the uniqueness of each employee, the personalization of his work environment and career path, the flexibility of the task setting process and communication with the manager and the openness of communication with other employees. Examples of factors that increase the effectiveness of creative activity are presented.
Comparison of Russian accounting standards and international financial reporting standards: problems of implementation and development prospects
Authors: Жердева О.В. , Небавская Т.В. , Беседина М.А. , Кудрич О.В. 
Published: June 2024

Вопрос активной адаптации отечественной системы учета и отчетности в соответствии с требованиями международных стандартов на сегодняшний день является актуальным, поскольку данный процесс вызван необходимостью увеличения степени влияния России на международной арене, что оказалось проблематичным в масштабах российских стандартов, а также развитием долгосрочных отношений и привлечением инвестиций иностранных партнеров в российский бизнес. В статье рассмотрена сравнительная характеристика международных стандартов финансовой отчетности с российскими стандартами бухгалтерского учета, представлены основные проблемы внедрения МСФО в отечественную практику и пути их решения.
The issue of active adaptation of the domestic accounting and reporting system in accordance with the requirements of international standards is relevant today, since this process is caused by the need to increase the degree of Russia’s influence in the international arena, which turned out to be problematic on the scale of Russian standards, as well as the development of long-term relationships and attracting investments from foreign partners in Russian business. The article examines the comparative characteristics of international financial reporting standards with Russian accounting standards, presents the main problems of introducing IFRS into domestic practice and ways to solve them.
Comparison of YandexGPT and ChatGPT in conducting some types of marketing analyses
Authors: Пальмов С.В. , Варлухин В.В. , Сочеева М.Е. 
Published: June 2024

Нейросети сегодня применяются для решения большого круга задач в совершенно разных сферах деятельности. С их помощью проводятся в том числе и различные виды анализа, которые применяются в маркетинге и стратегическом менеджменте. В статье рассматривается вопрос использования нейронных сетей YandexGPT и ChatGPT для проведения SWOT-, PEST-анализа, а также анализа пяти сил Портера.
Neural networks are used today to solve a wide range of tasks in completely different fields of activity. With their help, various types of analysis are carried out, which are used in marketing and strategic management. This article discusses the use of the YandexGPT and ChatGPT neural networks for SWOT, PEST analysis, as well as Porter’s five forces analysis.
Play as Occupation: The State of Our Science and a Research Agenda for the Profession
Authors: Kuhaneck Heather , Bundy Anita , Fabrizi Sarah , Lynch Helen , Moore Alice , Román-Oyola Rosa , Stagnitti Karen , Waldman-Levi Amiya 
Published: June 2024

AbstractOccupational therapists view play through a unique lens. Considering play as a human occupation, and one to which all people have a right, places occupational therapists among a special group of professionals championing play. This State of the Science article seeks to increase awareness regarding the occupational therapy profession’s contributions and to situate those contributions within the larger body of literature on play while also promoting further study of play as an occupation.
Fatigue of oncological patients – incompatible perspectives of patients and medical staff
Authors: Zdun-Ryżewska Agata E. , Błażek Magdalena , Wasilewko Iwona 
Published: June 2024

BackgroundCancer-related fatigue is a complex syndrome and the most frequently reported complaint, especially during treatment. Sometimes a large discrepancy in patient fatigue estimations between the patients themselves and medical staff is observed. The main goal of this study was to compare fatigue from the patients’ and the medical staff’s perspectives.Participants and procedureThe methods used included author-designed surveys for both the patient (questions about fatigue, intensity, causes and influence on life constructed mostly in the form of numerical rating scales) and the medical staff (the same questions on the perception of the patient’s fatigue), the Chalder Fatigue Questionnaire, and the EORTC QLQ-C30. The study involved 51 cancer patients during chemotherapy treatment.ResultsFor 63% of the subjects, there was convergence of fatigue assessments made by patients and staff. Differences were visible in the staff’s and patients’ assessment of the intensity of fatigue experienced by the patients. The simple question “Are you fatigued (yes or no)?” corresponded to all questionnaires and scales in the case of patients. The equivalent question to the staff, “Is the patient fatigued (yes or no)?”, corresponded only to the patients’ current assessment of fatigue and with no other score on the questionnaire or scale that the patients filled out about their fatigue. Also, patients identified more causes of fatigue and staff overestimated the influence of chemotherapy on fatigue. Of the patient subjects, 51.4% did not know of any ways to cope with fatigue, and most of them talked about it only to family and friends.ConclusionsDespite existing recommendations on the need to screen and educate patients in this matter, the issue of fatigue still re-quires attention.
Gambaran Pelaksanaan Pelayanan Posyandu Prakonsepsi pada Wilayah Terendah Stunting di Kabupaten Banggai
Authors: Halilu Magfira , Lanyumba Fitriyanti Sutadi , Lalusu Erni Yusnita , Thirayo Yunita Sari , Monoarfa Yustiyanti 
Published: June 2024

Posyandu prakonsepsi merupakan pelayanan wanita usia subur reproduksi sebelum kehamilan. Tujuan penelitian ini adalah untuk mengetahui gambaran pelaksanaan posyandu prakonsepsi pada wilayah terendah stunting di Kabupaten Banggai. Penelitian ini menggunakan jenis penelitian survey deskriptif dengan populasi seluruh WUS di wilayah Kecamatan Batui tahun 2022. Sampel penelitian berjumlah 200 orang dengan teknik pengambilan sampel menggunakan purposive sampling. Metode pengumpulan data yang digunakan yaitu data primer dan data sekunder. Analisis data yang digunakan adalah analisis univariat. penelitian menunjukkan bahwa kegiatan inti posyandu prakonsepsi meliputi penimbangan berat badan, pengukuran tinggi badan, pengukuran LILA, pengukuran tekanan darah, pengukuran lingkar panggul dan lingkar pinggang, pemberian konseling gizi, pemberian suplemen gizi, imunisasi TT calon pengantin sudah terlaksana (100%). Untuk pengukuran Hemoglobin ada 2 Desa yang tidak melaksanakan yaitu Desa Nonong dan Uso. Berdasarkan hasil tersebut, perlu adanya pengembangan dan pendampingan posyandu prakonsepsi untuk mendapat dukungan dan komitmen yang kuat dari berbagai stakeholders serta perlu adanya alat pemeriksa Hemoglobin (Hb) di wilayah tersebut.
Posyandu Preconception is a service for women of childbearing age before pregnancy. The purpose of this study was to describe the implementation of the preconception posyandu in the lowest stunting area in Banggai Regency. This study uses a descriptive survey research with a population of all WUS in Batui Regency in 2022. The research sample amounted to 200 people with the sampling technique using purposive sampling. Data collection methods used are primary data and secondary data. Analysis of the data used is univariate analysis. The results showed that the core activities of the preconception posyandu included weighing, measuring height, measuring LILA, measuring blood pressure, measuring hip and waist circumference, providing nutritional counseling, providing nutritional supplements, TT immunization for prospective brides (100%). ). For Hemoglobin measurement, there are 2 villages that do not implement it, namely Nonong Village and Uso Village. Based on these results, it is necessary to provide guidance and assistance to the preconception posyandu to get strong support and commitment from various stakeholders and the need for hemoglobin (Hb) checkers in the area.
Gambaran Intensitas Kebisingan Pada Masyarakat Yang Tinggal di Sekitar PLTD Kabupaten Banggai Tahun 2023
Authors: Rahman Reinhad Hidayat , Sattu Marselina , Sakati Sandy Novryanto 
Published: June 2024

Bunyi adalah sesuatu yang tidak dapat kita hindari dalam kehidupan sehari-hari, termasuk tempat kerja. Bahkan bunyi yang kita tangkap melalui telinga merupakan bagian dari kerja, misalnya bunyi telepon, bunyi mesin cetak, dan lain sebagainya. Bunyi yang berlebihan dapat mengakibatkan timbulnya kebisingan. Kebisingan yang berlebihan dapat merusak kemampuan untuk mendengar (menjadi tuli). Akibat pemajanan terhadap bising, kebanyakan atau umumnya tidak dapat disembuhkan (tidak dapat diobati). Tujuan penelitian ini mengetahui tingkat kebisingan di Kawasan Pemukiman Sekitar PLTD Luwuk. Jenis penelitian ini merupakan penelitian kualitatif dengan lokasi penelitian di kawasan pemukiman sekitar PLTD Luwuk. Pengambilan sampel dilakukan secara purposive sampling sesuai SNI 8427 Tahun 2017 dengan 4 titik pengukuran yang beradius 5, 10, 15 dan 20 m. Pengambilan data dilakukan dengan lembar pengambilan data KMNLH No. 48 Tahun 1996. Hasil penelitian ini menunjukan bahwa tingkat kebisingan dikawasan pemukiman sekitar PLTD Luwuk melebihi standar baku mutu kebisingan dikawasan pemukiman dimana hasil didapatkan >55 dBA atau pada Titik 1= 72,70, Titik 2= 75,55, Titik 3= 71,24. Dan titik 4= 79,73 Saran bagi penentu kebijakan, DLH, dan masyarakat agar dapat melakukan penanggulangan kebisingan dikawasan pemukiman PLTD luwuk.
Sound is something we cannot avoid in everyday life, including at work. Even the sounds we perceive through our ears are part of our work, for example the sound of a telephone, the sound of a printing machine. Excessive sound can cause noise. Excessive noise can damage the ability to hear (deafness). As a result of exposure to noise, most or generally are incurable (cannot be treated). The aim of this research is to determine the noise level in residential areas around in PLTD Luwuk. This type of aim is qualitative with locations in residential areas around in PLTD Luwuk. Sampling was carried out using purposive sampling according to SNI 8427 of 2017 with 4 measurement points with a radius of 5, 10, 15 and 20 m. Data collection was carried out using KMNLH data collection sheet No. 48 of 1996. The results of this research show that the noise level in the residential area around in PLTD Luwuk exceeds the noise quality standards in residential areas where the results obtained are >55 dBA or at Point 1= 72.70, Point 2= 75.55, Point 3= 71.24 and point 4 = 79.73 Suggestions for policy makers, DLH, and the community to be able to overcome noise in the Luwuk PLTD residential area.
Detecção de antígenos em cortes parafinados de vermes e caramujos infectados por Angiostrongylus cantonensis pela reação de imunofluorescência
Authors: Souza Felipe  Correa Rezende de , Melo Leyva Cecília Vieira de , Kanamura Cristina , Mota Dan Jessé Gonçalves da , Chiodelli Silvia Gabriel , Silva Pinto Pedro Luiz 
Published: June 2024

A Reação de Imunofluorescência Indireta (RIFI) foi utilizada para localizar antígenos em estruturas estágio-específicas em cortes parafinados de vermes fêmeas e em tecidos de caramujos do Gênero Biomphalaria infectados com larvas de terceiro estágio de Angiostrongylus cantonensis. Soros de casos confirmados de meningite eosinfílica foram usados para avaliação da reatividade. Soros não reagentes de casos suspeitos; de pacientes com outras parasitoses e de indivíduos sem outras etiologias foram utilizados como controle de reatividade cruzada. Anticorpos da classe IgG foram reativos para antígenos presentes nos dois estágios e, anticorpos IgM somente para o estágio larvário. Nos cortes de vermes, as marcações fluorescentes foram assinaladas nas cutículas e estruturas internas, com acentuada marcação para os conteúdos uterinos. Nos tecidos dos caramujos as larvas foram encontradas exclusivamente no interior dos granulomas, com marcações fluorescentes nas cutículas das larvas e no interior dos tecidos granulomatosos. O padrão de fluorescência no granuloma sugere a marcação de antígenos excretores/secretores. Reatividade cruzada mais expressiva ocorreu com anticorpos presentes em soros de pacientes com outras parasitoses, com destaque para estrongiloidíase. A RIFI em cortes parafinados abre novas perspectivas para identificação de antígenos e de marcadores sorológicos, que possam ser aplicados no aprimoramento do diagnóstico laboratorial da meningite eosinofílica.
Development of heat integration methods and their testing at prime and secondary oil refining plants**
Authors: Васильев М.А. , Канищев М.В. , Чибисов Р.Е. 
Published: June 2024

В нефтеперерабатывающей, химической и нефтехимической про-мышленности основные операционные затраты приходятся на топливно-энергетические ресурсы, необходимые для нагрева и охлаждения сырья и произведенных продуктов. В работе рассматриваются подходы для оптимизации действующих рекуперативных теплообменных систем (РТС) с учетом имеющихся технологических ограничений. Разра-ботанный авторами алгоритм основан на методах пинч-анализа, при этом существенно дополняет алгоритмы поиска оптимального размещения РТС. Реализация алгоритма в виде программного обеспечения позволит осуществлять поиск оптимальной конфигура-ции РТС в зависимости от различных критериев оптимума с учетом технических и эко-номических ограничений, уменьшив влияние человеческого фактора, а также позволит сократить время от начала разработки решения до окончания реализации проекта по внедрению оптимальной РТС.
In the oil refining, chemical and petrochemical industries, the main operating costs fall on fuel and energy resources necessary for heating and raw materials cooling and manufactured products. This paper discusses approaches for optimizing operating regenerative heat exchange systems (RHES), taking account of the available technological constraints. The algorithm developed by the authors is based on pinch analysis methods, while significantly complementing the algorithms for finding optimal RHES placement. Realization of the algorithm in the form of software will make it possible to search for the optimal RHES configuration de-pending on various optimum criteria taking into account technical and economic constraints, reducing the influence of the human factor, as well as reduce the time from the beginning of so-lution development to the end of the project to implement the optimal RHES.