bluuebunny/crossref_metadata_2025_split huggingface dataset:
Melanoma and vitamin D
Authors: Field Sinead , Newton-Bishop Julia A. 
Published: February 2011

Vitamin D is a fat‐soluble steroid hormone, which is essential to health and for which epidemiological studies suggest a role in autoimmune disease, infections, cardiovascular disease and cancer. It is ingested in foods such as oily fish and supplements, so that average levels vary between countries, but most individuals worldwide make most of their vitamin D as a result of the effects of sun exposure on the skin. Many studies in different populations around the world have in recent years shown that sub‐optimal levels of vitamin D (<70 nmol/L) are common. A series of epidemiological studies have suggested that low vitamin D levels increase the risk of cancers, particularly of the breast and gastrointestinal tracts, so that there has been much interest in understanding the effects of vitamin D on cancer cells. Vitamin D binds to the vitamin D receptor (VDR) resulting in transcription of a number of genes playing a role in inhibition of MAPK signalling, induction of apoptosis and cell‐cycle inhibition, and therefore vitamin D has anti‐proliferative and pro‐apoptotic effects in cells of many lineages. It also has suppressive effects on adaptive immunity and is reported to promote innate immunity. Here we review data on vitamin D and melanoma. There are in vitro data, which suggest that vitamin D has the same anti‐proliferative effects on melanoma cells as have been demonstrated in other cells. We have reported data to suggest that vitamin D levels at diagnosis have a role in determining outcome for melanoma patients. There is a curious relationship between melanoma risk and sun exposure where sunburn is causal but occupational sun exposure is not (at least in temperate climes). Seeking to understand this, we discuss data, which suggest (but by no means prove) that vitamin D might also have a role in susceptibility to melanoma. In conclusion, much remains unknown about vitamin D in general and certainly about vitamin D and melanoma. However, the effects of avoidance of suboptimal vitamin D levels on cancer cell proliferation are likely to be beneficial to the melanoma patient. The possible results of high vitamin D levels on the immune system remain unclear however and a source of some concern, but the data support the view that serum levels in the range 70–100 nmol/L might be a reasonable target for melanoma patients as much as for other members of the population.
Comparative effects of glucose and xylose on blood pressure, gastric emptying and incretin hormones in healthy older subjects
Authors: Vanis Lora , Hausken Trygve , Gentilcore Diana , Rigda Rachael S. , Rayner Christopher K. , Feinle-Bisset Christine , Horowitz Michael , Jones Karen L. 
Published: February 2011

Postprandial hypotension is an important disorder for which current management is suboptimal. In healthy older subjects, oral and small-intestinal glucose administration decreases blood pressure (BP), and the magnitude of the reduction is dependent on the rate of glucose entry into the small intestine and, possibly, the release of glucagon-like peptide-1 (GLP-1). There is little information about the effects of other carbohydrates, particularly those poorly absorbed, on BP. The aim of the present study was to compare the effects of drinks containing xylose, glucose or water alone on BP, gastric emptying (GE), incretin hormone secretion, glycaemia and insulinaemia in healthy older subjects. A total of eight healthy older subjects (aged 65–75 years) had simultaneous measurements of BP (DINAMAP), GE (three-dimensional ultrasound), blood glucose, serum insulin, GLP-1 and glucose-dependent insulinotropic peptide (GIP), on three separate occasions, in a double-blind, randomised order. On each day, subjects consumed a 300 ml drink of water, glucose (50 g) ord-xylose (50 g). Glucose (P = 0·02), but not xylose (P = 0·63), was associated with a fall in BP. There was no difference in the GE of glucose and xylose (P = 0·47); both emptied slower than water (P < 0·001). Xylose had minimal effects on blood glucose, serum insulin or serum GIP, but was more potent than glucose in stimulating GLP-1 (P = 0·002). In conclusion, in healthy older subjects, xylose empties from the stomach at the same rate as glucose, but has no effect on BP, possibly because it is a potent stimulus for GLP-1 release. Xylose may be considered as an alternative sweetener to glucose in the management of postprandial hypotension.
Flying with a ‘death sentence’ on board: electrophoretic detection of braconid parasitoid larvae in migrating winged grain aphids,Sitobion avenae(F.)
Authors: Walton M.P. , Loxdale H.D. , Allen-Williams L.J. 
Published: February 2011

AbstractPolyacrylamide gel electrophoresis of enzymes (carboxylesterases) was used for the first time to monitor rates of parasitism in airborne alate (winged) grain aphid,Sitobion avenae(F.) population samples collected by suction trapping in Hertfordshire, UK. Using previously described electrophoretic ‘keys’, the species of hymenopterous parasitoids present in individual aphids were identified and found to beAphidius ervi(Haliday) and/orAphidius rhopalosiphi(De Stephani Perez) (Braconidae). Entomophthoralean fungal infection was also detected using this approach. Aphidiid wasp parasitism was detected from early June to mid-August and fungal infection from late June to late July. The results are discussed in relation to parasitoid population structure and dynamics, especially (i) the fact that winged aphids passively transport the early stages of their braconid parasitoids and fungal pathogens, potentially to newly-founded colonies, which may directly impact on the dual aphid-parasitoid populations genetics; and (ii) the approach used to collect and assay parasitised and fungal infected aphids involving both suction trapping and electrophoretic testing may have potential in assessing the level and efficacy of these biological control agents in integrated pest management (IPM) schemes to combat cereal aphid outbreaks.
Evolution of the bump-on-tail instability in compressing plasma
Authors: SCHMIT P. F. , MOONEY C. R. , DODIN I. Y. , FISCH N. J. 
Published: February 2011

AbstractThrough particle-in-cell simulations, the evolution of the bump-on-tail instability (BoTI) is studied for plasma subject to one-dimensional mechanical compression. It is shown that the final state of BoTI differs from that described by quasilinear theory for stationary bulk plasma and can depend on the compression history. The transformation of thermal energy into wave energy increases the plasma compressibility, thereby decreasing the amount of mechanical work required to compress the plasma to a specified size. Also, the energy spectrum of the excited modes can be tailored by choosing a particular compression scenario, offering a new technique for manipulating plasmas mechanically.
Directions and beliefs of self-presentational bias
Authors: Funder David C. 
Published: February 2011

AbstractThe target article tends to conflate self-deception and self-enhancement, but biased self-presentation can be negative as well as positive. Self-deceiving self-diminishers may be depressed and non-self-deceiving self-diminishers may project false modesty. The article's otherwise brilliant argument for the advantages of self-deceptive self-enhancement for deceiving others may underemphasize the risks it entails for poor decision making.
Two problems with “self-deception”: No “self” and no “deception”
Authors: Kurzban Robert 
Published: February 2011

AbstractWhile the idea that being wrong can be strategically advantageous in the context of social strategy is sound, the idea that there is a “self” to be deceived might not be. The modular view of the mind finesses this difficulty and is useful – perhaps necessary – for discussing the phenomena currently grouped under the term “self-deception.”
Self-deception: Adaptation or by-product?
Authors: Mercier Hugo 
Published: February 2011

AbstractBy systematically biasing our beliefs, self-deception can endanger our ability to successfully convey our messages. It can also lead lies to degenerate into more severe damages in relationships. Accordingly, I suggest that the biases reviewed in the target article do not aim at self-deception but instead are the by-products of several other mechanisms: our natural tendency to self-enhance, the confirmation bias inherent in reasoning, and the lack of access to our unconscious minds.
Conscious thinking, acceptance, and self-deception
Authors: Frankish Keith 
Published: February 2011

AbstractThis commentary describes another variety of self-deception, highly relevant to von Hippel & Trivers's (VH&T's) project. Drawing on dual-process theories, I propose that conscious thinking is a voluntary activity motivated by metacognitive attitudes, and that our choice of reasoning strategies and premises may be biased by unconscious desires to self-deceive. Such biased reasoning could facilitate interpersonal deception, in line with VH&T's view.
The weightless hat: Is self-deception optimal?
Authors: Khalil Elias L. 
Published: February 2011

AbstractThere are problems with the thesis of von Hippel & Trivers (VH&T): (1) It entails that self-deception arises from interpersonal deception – which may not be true; (2) it entails that self-deception is optimal – which is not necessarily so; and (3) it entails that interpersonal deception is optimum – which may not be true.
Scaling the Period Eye: Oscar Drude and the Cartographical Practice of Plant Geography, 1870s–1910s
Authors: Güttler Nils Robert 
Published: February 2011

ArgumentThe historiography of botanical maps has mainly concentrated on their alleged “golden age,” on maps drawn by famous first-generation plant geographers. This article instead describes botanical maps after the age of discovery, and detects both a quantitative explosion and qualitative modification in the late nineteenth century. By spotlighting the case of the plant geographer Oscar Drude (1852–1933), I argue that the dynamics of botanical mappings were closely linked to a specific milieu of knowledge production: the visual culture of Imperial Germany. The scientific upgrading of maps was stimulated by a prospering commercial cartographical market as well as a widespread practice of mediating between professionals and amateurs via maps in the public sphere. In transferring skills and practices from these “popular” fields of knowledge to scientific domains, botanists like Oscar Drude established maps as an indispensable element of botanical observation. This wholesale dissemination of botanical maps had thus a formative influence on collective perception – the botanist's “period eye” – regarding plant distribution.
Summer–winter transitions in Antarctic ponds I: The physical environment
Authors: Hawes Ian , Safi Karl , Sorrell Brian , Webster-Brown Jenny , Arscott David 
Published: February 2011

AbstractMeltwater ponds are one of the most widespread aquatic habitats in ice-free areas of continental Antarctica. While most studies of such systems occur during the Antarctic summer, here we report on ice formation and water column attributes in four meltwater ponds on the McMurdo Ice Shelf during autumn, when they went from ice-free to > 80 cm thickness of ice. Ice thickness grew at an average rate of 1.5 cm d-1in all ponds and as ice formed, salts and gases were excluded. This resulted in conductivity rising from 3–5 to > 60 mS cm-1and contributed to the ebullition of gases. Incorporation of gas bubbles in the ice resulted in a high albedo and under-ice irradiance declined faster than incident, the former falling below 1 W m-2(daily average) by early April. After two months of ice formation, only 0–15% of the volume of each pond was still liquid, although this represented 5–35% of the pond sediment area, where much of the biological activity was concentrated. We suggest that the stresses that the freezing process imposes may be as important to structuring the biotic communities as those during the more benign summer growth period.
The value of air quality and crime in Chile: a hedonic wage approach
Authors: LAVÍN FELIPE VÁSQUEZ , DRESDNER JORGE , AGUILAR RENATO 
Published: February 2011

ABSTRACTWe estimate the implicit prices of the crime rate and airborne pollution in Chile, using spatially compensating price differentials in the housing and labor markets. We evaluate empirically the impact of different estimation strategies for the wage and rent equations, on the economic value of these two amenities. The results show that increments in the crime rate or in air pollution have a negative impact on welfare and that the estimated welfare measures and their variances are sensitive to selection bias, endogenous amenities and clustering effects. In contrast, the welfare measures do not seem to be very sensitive to the simultaneity bias.
Healthy eating in early years settings: a review of current national to local guidance for North West England
Authors: Bristow Katie , Capewell Simon , Abba Katharine , Goodall Mark , Lloyd-Williams Ffion 
Published: February 2011

AbstractObjectiveTo determine the extent to which national and local UK guidelines for the early years sector address key recommendations for encouraging healthy eating based on best available evidence.DesignPhase 1 comprised a literature review to identify new evidence to assess current relevance of the Caroline Walker Trust (CWT) ‘Eating well for under-5 s in child care’ guidelines. Phase 2 assessed the completeness of seven local to national-level government guidelines by comparison with the ‘gold standard’ CWT guidelines.SettingDesk-based review using secondary data.SubjectsResearch literature and statutory guidelines on healthy eating in early years settings.ResultsPhase 1 retrieved seventy-five papers, of which sixty were excluded as they addressed compliance with nutritional and food-based standards only. One report examined a social marketing tool and was deemed too narrow. The remaining fourteen documents assessed interventions to encourage healthy eating in early years settings. Following quality assessment, seven documents were included. Nine key recommendations were identified: (i) role of government; (ii) early years setting policy/guidelines; (iii) training; (iv) menu planning; (v) parents; (vi) atmosphere and encouragement; (vii) learning through food; (viii) sustainability; and (ix) equal opportunities. Phase 2 identified that all seven guidelines included the nine key recommendations but sporadic cover of sub-key recommendations.ConclusionsMore detail is needed on how early years settings can encourage children to eat healthily. Research is required to develop second-layer guidance for interactive materials. Clear processes of communication and support for parents are required. Ways food relates to children's wider learning and social development need further thought, requiring collaboration between the Department of Health and the Department for Education.
A Review of Ultrastructural and Ultracytochemical Studies of Infection Processes in Some Plant Wilt Diseases: The Opaque Matter Extensively Involved, Its Links with Pathogen Elements, Insights into Its Nature
Authors: Ouellette G.B. , Charest P.M. , Chamberland H. 
Published: February 2011

AbstractThe present review is based on results of several years of investigation on the pathogenesis of plant wilt diseases using for one of the main aspects, several labeling techniques at the ultrastructural level: autoradiography with3H-thymidine; gold-tagged lectins, enzymes, polyclonal, and monoclonal antibodies. Thus, opaque matter (OM), labeling for DNA with the appropriate markers, can be abundant in and associated with host tissue reactions and pronounced alterations (particularly in newly differentiated xylem). The presence of structures (called P-elements) in OM, paralleled by a similar occurrence in nuclei of both the host and pathogen cells, is considered as being also indicative of a cytoplasmic nature for this OM and most likely originating from fungal elements.
Solving functional constraints by variable substitution
Authors: ZHANG YUANLIN , YAP ROLAND H. C. 
Published: February 2011

AbstractFunctional constraints and bi-functional constraints are an important constraint class in Constraint Programming (CP) systems, in particular for Constraint Logic Programming (CLP) systems. CP systems with finite domain constraints usually employ Constraint Satisfaction Problem(s)-based solvers which use local consistency, for example, arc consistency. We introduce a new approach which is based instead on variable substitution. We obtain efficient algorithms for reducing systems involving functional and bi-functional constraints together with other nonfunctional constraints. It also solves globally any CSP where there exists a variable such that any other variable is reachable from it through a sequence of functional constraints. Our experiments on random problems show that variable elimination can significantly improve the efficiency of solving problems with functional constraints.
Preoperative Dexamethasone Enhances Quality of Recovery after Laparoscopic Cholecystectomy
Authors: Murphy Glenn S. , Szokol Joseph W. , Greenberg Steven B. , Avram Michael J. , Vender Jeffery S. , Nisman Margarita , Vaughn Jessica 
Published: February 2011

Background
The effect of dexamethasone on quality of recovery after discharge from the hospital after laparoscopic surgery has not been examined rigorously in previous investigations. We hypothesized that preoperative dexamethasone would enhance patient-perceived quality of recovery on postoperative day 1 in subjects undergoing laparoscopic cholecystectomy.

Methods
One hundred twenty patients undergoing outpatient laparoscopic cholecystectomy were randomized to receive either dexamethasone (8 mg) or placebo-saline. A 40-item quality-of-recovery scoring system (QoR-40) was administered preoperatively and on postoperative day 1 to all subjects. Nausea, vomiting, fatigue, and pain scores were recorded at the time of discharge from the postanesthesia care unit and ambulatory surgical unit. Hospital length of stay was also assessed.

Results
Global QoR-40 scores on postoperative day 1 were higher in the dexamethasone group (median [range], 178 [130-195]) compared with the control group (161 [113-194]) (median difference [99% CI], -18 [-26 to -8]; P < 0.0001). Postoperative QoR-40 scores in the dimensions of emotional state, physical comfort, and pain were all improved in the dexamethasone group compared with the control group (P < 0.001). Nausea, fatigue, and pain scores were all reduced in the dexamethasone group during the hospitalization, as were postoperative analgesic requirements (P < 0.05). Total hospital length of stay was also reduced in subjects administered steroids (P = 0.003).

Conclusions
Among patients undergoing outpatient laparoscopic cholecystectomy surgery, the use of preoperative dexamethasone enhanced postdischarge quality of recovery and reduced nausea, pain, and fatigue in the early postoperative period.
Comparison of the Neuroapoptotic Properties of Equipotent Anesthetic Concentrations of Desflurane, Isoflurane, or Sevoflurane in Neonatal Mice
Authors: Istaphanous George K. , Howard Jennifer , Nan Xinyu , Hughes Elizabeth A. , McCann John C. , McAuliffe John J. , Danzer Steve C. , Loepke Andreas W. 
Published: February 2011

Background
Volatile anesthetics facilitate surgical procedures and imaging studies in millions of children every year. Neuronal cell death after prolonged exposure to isoflurane in developing animals has raised serious concerns regarding its safe use in children. Although sevoflurane and desflurane are becoming more popular for pediatric anesthesia, their cytotoxic effects have not been compared with those of isoflurane. Accordingly, using newborn mice, the current study established the respective potencies of desflurane, isoflurane, and sevoflurane and then compared equipotent doses of these anesthetics regarding their effects on cortical neuroapoptosis.

Methods
Minimum alveolar concentrations were determined in littermates (aged 7-8 days, n = 42) using tail-clamp stimulation in a bracketing study design. By using equipotent doses of approximately 0.6 minimum alveolar concentration, another group of littermates was randomly assigned to receive desflurane, isoflurane, or sevoflurane or to fast in room air for 6 h. After exposure, animals (n = 47) were euthanized, neocortical apoptotic neuronal cell death was quantified, and caspase 3 activity was compared between the four groups.

Results
The minimum alveolar concentration was determined to be 12.2% for desflurane, 2.7% for isoflurane, and 5.4% for sevoflurane. After a 6-h exposure to approximately 0.6 minimum alveolar concentration of desflurane, isoflurane, or sevoflurane, neuronal cell death and apoptotic activity were significantly increased, irrespective of the specific anesthetic used.

Conclusions
In neonatal mice, equipotent doses of the three commonly used inhaled anesthetics demonstrated similar neurotoxic profiles, suggesting that developmental neurotoxicity is a common feature of all three drugs and cannot be avoided by switching to newer agents.
Spinal Macrophage Migration Inhibitory Factor Is a Major Contributor to Rodent Neuropathic Pain-like Hypersensitivity
Authors: Wang FuZhou , Xu ShiQin , Shen XiaoFeng , Guo XiRong , Peng YuZhu , Yang Jie 
Published: February 2011

Background
Neuropathic pain-like hypersensitivity evoked by peripheral nerve injury is a salient clinical feature of pathologic pain; however, the underlying mechanisms of this condition remain largely unknown. Previous work has confirmed that spinal macrophage migration inhibitory factor (MIF) contributes to the pathogenesis of formalin-induced inflammatory hyperalgesia, but the role for MIF in neuropathic pain is still not well defined.

Methods
After approval by the Ethical Committee of Animal Use and Care, the sciatic chronic constriction nerve injury-induced rodent model of neuropathic pain was built. The mechanical threshold with von Frey hairs and thermal latency with hot plate were measured, and the expression of spinal MIF, CD74, and downstream extracellular signal-regulated kinase 1/2 signaling cascade was detected. Finally, MIF gene mutation and exogenous recombinant MIF were used for further clarification.

Results
Intrathecal MIF tautomerase inhibitor reversed sciatic chronic constriction nerve injury-induced pain behaviors. The expression of MIF and CD74 up-regulated in a time-dependent manner in the ipsilateral spinal cord dorsal horn. These changes were associated with the activation of extracellular signal-regulated kinase 1/2 signaling by MIF/CD74 interaction, which subsequently led to up-regulation of interleukin-8 and N-methyl-D-aspartic acid receptor expression and additional production of prostaglandin E(2). Further, MIF gene mutation and exogenous recombinant MIF could desensitize and mimic sciatic chronic constriction nerve injury-evoked pain responses and cellular changes, respectively.

Conclusions
MIF-associated extracellular signal-regulated kinase 1/2-N-methyl-D-aspartic acid receptor or prostaglandin E(2) cascade accounts for the changes in peripheral nerve injury-induced nociceptive responses.