bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mitral Isthmus Ablation with and Without Temporary Spot Occlusion of the Coronary Sinus: A Randomized Clinical Comparison of Acute Outcomes
Authors: HOCINI MÉLÈZE , SHAH ASHOK J. , NAULT ISABELLE , RIVARD LENA , LINTON NICK , NARAYAN SANJIV , MYIAZAKI SHINSUKE , JADIDI AMIR S. , KNECHT SÉBASTIEN , SCHERR DANIEL , WILTON STEPHEN B. , ROTEN LAURENT , PASCALE PATRIZIO , PEDERSEN MICHALA , DERVAL NICOLAS , SACHER FRÉDÉRIC , JAÏS PIERRE , CLÉMENTY JACQUES , HAÏSSAGUERRE MICHEL 
Published: January 2012

Role of CS Occlusion for Mitral Isthmus Ablation. Objective: To evaluate the safety and outcomes of mitral isthmus (MI) linear ablation with temporary spot occlusion of the coronary sinus (CS).Background: CS blood flow cools local tissue precluding transmurality and bidirectional block across MI lesion.Methods: In a randomized, controlled trial (CS‐occlusion = 20, Control = 22), MI ablation was performed during continuous CS pacing to monitor the moment of block. CS was occluded at the ablation site using 1 cm spherical balloon, Swan–Ganz catheter with angiographic confirmation. Ablation was started at posterior mitral annulus and continued up to left inferior pulmonary vein (LIPV) ostium using an irrigated‐tip catheter. If block was achieved, balloon was deflated and linear block confirmed. If not, additional ablation was performed epicardially (power ≤25 W). Ablation was abandoned after ∼30 minutes, if block was not achieved.Results: CS occlusion (mean duration −27 ± 9 minutes) was achieved in all cases. Complete MI block was achieved in 13/20 (65%) and 15/22 (68%) patients in the CS‐occlusion and control arms, respectively, P = 0.76. Block was achieved with significantly small number (0.5 ± 0.8 vs 1.9 ± 1.1, P = 0.0008) and duration (1.2 ± 1.7 vs 4.2 ± 3.5 minutes, P = 0.009) of epicardial radiofrequency (RF) applications and significantly lower amount of epicardial energy (1.3 ± 2.4 vs 6.3 ± 5.7 kJ, P = 0.006) in the CS‐occlusion versus control arm, respectively. There was no difference in total RF (22 ± 9 vs 23 ± 11 minutes, P = 0.76), procedural (36 ± 16 vs 39 ± 20 minutes, P = 0.57), and fluoroscopic (13 ± 7 vs 15 ± 10 minutes, P = 0.46) durations for MI ablation between the 2 arms. Clinically uneventful CS dissection occurred in 1 patientConclusions: Temporary spot occlusion of CS is safe and significantly reduces the requirement of epicardial ablation to achieve MI block. It does not improve overall procedural success rate and procedural duration. Tissue cooling by CS blood flow is just one of the several challenges in MI ablation. (J Cardiovasc Electrophysiol, Vol. 23, pp. 489‐496, May 2012)
Moderators of the synchrony of change between decreasing depression severity and disability
Authors: Verboom C. E. , Ormel J. , Nolen W. A. , Penninx B. W. J. H. , Sijtsema J. J. 
Published: January 2012

Verboom CE, Ormel J, Nolen WA, Penninx BWJH, Sijtsema JJ. Moderators of the synchrony of change between decreasing depression severity and disability.Objective:  To identify moderators of synchrony of change between depression severity and disability.Method:  From a large cohort study with 2 years of follow‐up, patients with major depressive disorder at baseline who decreased at least 25% in depression severity after 2 years (n = 245) were selected. We measured overall and domain‐specific disability at baseline, and at 1‐ and 2‐year follow‐up. Possible moderators, among which several demographic, clinical, personality, and contextual factors, were measured at baseline. We used linear mixed models to analyze the data.Results:  Decrease in depression severity correlated strongly with reductions of overall disability (r = 0.54). Synchrony of change for the disability domains ranged from 0.13 for self‐care to 0.47 for participation. From the possible moderators, only age and work stress moderated the association between change in depression severity and disability, with stronger synchrony of change among younger patients and patients who experienced moderate work stress.Conclusion:  Strong synchrony of change exists between depression severity and disability. Perhaps, because of the strength of this synchrony, few contextual characteristics moderated the association. Clinicians should be aware of the risk of slower or incomplete functional recovery in older people and those without a job or those experiencing low work stress.
Mannose‐binding lectin genotype and serum levels in patients with chronic and allergic pulmonary aspergillosis
Authors: Harrison E. , Singh A. , Morris J. , Smith N. L. , Fraczek M. G. , Moore C. B. , Denning D. W. 
Published: January 2012

SummarySeveral studies suggest mannose‐binding lectin (MBL) deficiency is associated with various manifestations of aspergillosis. MBL serum levels and function are genetically determined, but levels rise during inflammation. We address the relative frequency of deficient genotypes, the relationship between serum level and genotype and both age and disease manifestations in patients with chronic pulmonary (CPA) and allergic bronchopulmonary aspergillosis (ABPA) and severe asthma with fungal sensitization (SAFS). DNA was extracted from blood samples, and MBL2 genotyping was performed using the INNO‐LiPA MBL2 kit. Serum MBL concentrations were determined using ELISA. One hundred and eight patients were evaluated, 70 (65%) with CPA, 38 (35%) with allergic disease (ABPA, SAFS or undefined) and 13 (12%) had both CPA and ABPA. The mean MBL serum level was 1849 μg L−1 and did not differ between groups. Forty subjects (37%) had exon 1 genotypes producing nonfunctional MBL (A/B, A/C, A/D and O/O), a frequency not different from published normal controls. A/A subjects with CPA had higher levels (2981 μg L−1) compared with allergic A/A subjects (2202 μg L−1) (pc0.012). No single haplotype, genotype or allele was significantly related to any aspergillosis phenotype. Worse breathlessness was associated with higher MBL levels among A/A subjects (P = 0.009) and conversely nonfunctional genotypes. Mean MBL values were higher in those with an Medical Research Council (MRC) breathlessness score of 5 compared with those with and MRC score of 1 (P = 0.023). A/A allergic subjects (n = 27) in this study were ∼11 years younger than allergic A/O subjects (n = 11, P = 0.02). Subjects with worse respiratory status or more severe CPA had higher MBL serum levels (P = 0.023; P = 0.034). Bronchiectasis was not associated with MBL levels in CPA or allergic aspergillosis. MBL genotype and serum level modulate progression of aspergillosis.
Detection of two HLA‐B*27 alleles, B*27:25 and B*27:86, in two Taiwanese blood donors by sequence‐based typing
Authors: Yang E. K. L. , Lee S. K. , Lin P. Y. 
Published: January 2012

SummaryWe report here two HLA‐B*27 alleles, B*27:86 and B*27:25, found in two Taiwanese blood donors. The new sequence of B*27:86 is identical to B*27:04:01 in exons 2 and 3, except at nucleotide 602 (A→G) in exon 3. The nucleotide change caused an amino acid substitution from E to G at amino acid residue 177. The sequence of B*27:25 is identical to B*27:04:01 in exons 2, 3, 4, 5, 6 and 7 except at nucleotides 538, 539, 559 and 560 in exon 4. The nucleotide changes caused amino acid substitutions from L to W and from E to L at residues 156 and 163, respectively. The generation of B*27:86 was probably resulted by a point mutation while the generation of B*27:25 may have been derived from a sequence recombination event between B*46:01:01 and B*27:04:01. The probable HLA‐A, ‐B and ‐DRB1 haplotypes in association with B*27:86 and B*27:25 may be deduced as A*11:53‐B*27:86‐DRB1*12 and A*11:01‐B*27:25‐DRB1*04:05, respectively.
RECOVERY AND UTILIZATION OF PROTEIN DERIVED FROM SURIMI WASH‐WATER
Authors: STINE J.J. , PEDERSEN L. , SMILEY S. , BECHTEL P.J. 
Published: January 2012

ABSTRACTSurimi processors are committed to improve utilization of seafood resources, increase productivity and reduce organic matter discharged into the environment. The object of this study was to recover protein from pollock surimi processing wash‐water using membrane filtration and characterize properties of the recovered material. A pilot unit equipped with membrane elements concentrated protein from the surimi wash‐water. Membrane concentrate and control surimi samples were analyzed for proximate composition, lipid oxidation, color, sodium dodecyl sulfate gel electrophoresis, amino acids and minerals. Membrane concentrate, membrane concentrate plus surimi and control surimi were monitored for 180 days of storage at −20C. The membrane concentrate had significantly higher moisture and lipid, but lower protein content than surimi. As determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis, membrane concentrate proteins displayed a greater amount of lower molar mass molecules compared with surimi. The amino acid profile was comparable to control surimi and the recovered membrane concentrate proteins had similar nutritional values to that of surimi. The results indicate that the addition of 5% membrane concentrate to surimi will not adversely affect the storage at −20C and that the recovered wash‐water protein could be used to obtain a fish protein ingredient or added back at a low percentage to surimi products.PRACTICAL APPLICATIONSIn order to increase productivity and improve utilization of seafood resources, surimi processors are looking into alternative technologies to recover proteins and other material from the wastewater. Membrane filtration is a promising option for the concentration of wastewater. This study was conducted to determine the recovery and characterize the material recovered from surimi wash‐water using a commercial membrane filtration unit. It was demonstrated that the recoverable material is nutritionally similar to the final surimi product and that the overall yield can be increased using membrane technology. In addition to the benefit of recovering protein, the membrane filtration can reduce the amount of material in the waste stream.
FUNDAMENTAL RHEOLOGY AND QUALITY CHARACTERISTICS OF SOUS‐VIDE PROCESSED APPLE PUREES CONTAINING APPLE OR BLACKCURRANT POMACE INCLUSIONS
Authors: KEENAN DEREK F. , BRUNTON NIGEL P. , GORMLEY RONAN , BUTLER FRANCIS 
Published: January 2012

ABSTRACTThe effect of pomace type and level of inclusion on the quality and rheological characteristics of sous‐vide processed apple puree (Bramley's Seedling) was evaluated. Purees containing apple (Shampion freeze‐dried, Shampion, Ariwa) and blackcurrant pomaces, at inclusion levels of 0, 2.5 and 5% w/w, were processed by sous‐vide (P90 > 10 min). Reductions in L* color values (P < 0.001) were observed in pomace type and inclusion level. Shampion pomace had the highest (P < 0.001) sensory acceptability (3.63) of the pomaces (control 4.21). Both pomace type and increasing pomace inclusions influenced (P < 0.001) rheological properties. This was supported by texture analysis, i.e., increase (P < 0.001) in extruded force with increasing pomace inclusion. The best performing pomace (Shampion) was included in sous‐vide purees at eight levels (0, 2.5, 5, 6, 7.5, 9, 10 and 12.5%, w/w). The highest pomace inclusion gave the firmest purees without affecting color. Sensory data indicated that purees with up to 7.5% w/w pomace were acceptable.PRACTICAL APPLICATIONSResearch has concluded that consumption of fruits and vegetables in Europe is substantially below World Health Organization guidelines (<400–600 g/day). As fruits are a significant source of fiber, it is important that their intake is maintained as part of a healthy diet. Providing a choice of fresh and minimally processed fruit products is the key to increasing consumption. Following the success of ready‐meals, the expectation for similar retail success exists for ready‐desserts. This study focused on assessing the effect of pomace inclusions on the quality parameters of sous‐vide processed Bramley's Seedling apple purees. The development of these products would benefit both consumers (health) and processors (cost‐effective way of adding value) alike. Inclusions of pomaces had significant effects on color, sensory and rheological parameters of apple purees. These outcomes may be of benefit to the food industry to develop better products.
First record of two fungivorous tenebrionids, Ischnodactylus parallelicornis (Nakane) and Platydema higonium Lewis (Coleoptera: Tenebrionidae: Diaperinae) from Korea with new fungal hosts
Authors: JUNG Boo Hee , LEE Jong Wook 
Published: January 2012

AbstractFungivorous tenebrionids, Ischnodactylus parallelicornis (Nakane 1956) and Platydema higonium Lewis, 1894 in the tribe Diaperini (Coleoptera: Tenebrionidae: Diaperinae), are recorded for the first time from Korea. Both I. parallelicornis and P. higonium are rare inhabitants of fungi on deciduous trees in Korea. These species all exhibit monophagy, with I. parallelicornis only inhabiting the fruiting body of Tramates orientalis and P. higonium only inhabiting the fruiting body of Stereum hirsutum and Stereum ostrea throughout their lives. A description, key to the Korean Ischnodoctylus and Platydema, fungal hosts, biological notes, photographs of adults and illustrations of diagnostic characteristics are provided herein.
Efficacy of fenofibrate in Chinese patients with primary biliary cirrhosis partially responding to ursodeoxycholic acid therapy
Authors: HAN Xiao Feng , WANG Qi Xia , LIU Yuan , YOU Zheng Rui , BIAN Zhao Lian , QIU De Kai , MA Xiong 
Published: January 2012

OBJECTIVE:  To investigate the efficacy of fenofibrate combination therapy in Chinese patients with primary biliary cirrhosis (PBC) who had a partial response to standard dose of ursodeoxycholic acid (UDCA) for at least one year.METHODS:  PBC patients were treated with UDCA (13–15 mg/kg/day) for more than one year. The biochemical response to UDCA treatment was evaluated after treatment. Fenofibrate (200 mg/day) was added to 22 patients with partial response to UDCA.RESULTS:  In patients with partial response to UDCA, serum alkaline phosphatase (ALP) and γ‐glutamyl transpeptidase levels significantly decreased after 3‐month combination therapy of UDCA and fenofibrate, 68% of these patients even reached normal ALP level. Serum triglyceride (TG) and cholesterol levels were improved, and alanine transaminase (ALT) and aspartate transaminase (AST) were also decreased during the combination therapy. However, fenofibrate had no significant effect on serum bilirubin levels. The improvement of liver biochemical tests was maintained in some patients with long‐term therapy (at least 6 months). No obvious adverse effects were observed in patients taking fenofibrate.CONCLUSIONS:  Fenofibrate is effective for improving liver biochemical tests in patients who have partial response to UDCA monotherapy. It is worth exploring the efficacy of fenofibrate on histological changes in PBC patients.
Evaluation of cell population data on the UniCel DxH 800 Coulter Cellular Analysis system as a screening for viral infection in children
Authors: JUNG Y‐J. , KIM J‐H. , PARK Y‐J. , KAHNG J. , LEE H. , LEE K‐Y. , KIM M. Y. , HAN K. , LEE W. 
Published: January 2012

SummaryIntroduction:  The utility of WBC cell population data (CPD) for the differential diagnosis of viral infection from normal control, bacterial infection, and tuberculosis in children was investigated.Methods:  A data set of 602 total whole‐blood samples were analyzed on the DxH 800 System for complete blood cell count (CBC) with leukocyte differential from children with the following sample breakdown: 77 confirmed diagnoses of viral infections (Epstein–Barr virus; 30, influenza A; 19, rota virus; 11, other viruses;17), 54 normal control, 71 bacterial infection, 17 TB patients, and 383 with various diseases. The mean (MN) and standard deviation (SD) of the volume (V), conductivity (C), five light‐scatter measurements, and 14 calculated parameters were obtained for the leukocytes.Results:  Using a combination of the CBC and CPD parameter values, a decision rule, composed of 21 parameters, for the screening of viral infection in children was developed. Using this decision rule, 74 of 77 (96.1%) viral infections, two of 54 (3.7%) normal samples, one of 17 (5.9%) TB, and six of 71 (8.5%) bacterial infection samples were identified. The sensitivity was 96.1%, and specificity for normal control was 96.3% with an overall specificity of 93.7%. Fifty‐nine samples of 383 samples (15.4%) collected from in‐patient children with various diseases without confirmation of viral infection were included in this decision rule.Conclusion:  In conclusion, the implementation of leukocytes CPD parameters can be useful in the detection of viral infection in children.
Caregiver causal attributions in youth psychosis
Authors: Clarke Kerrie , Couchman Grace 
Published: January 2012

AbstractAim: Caregiver causal attributions influence patient and caregiver reactions to psychosis. The current study describes common caregiver causal attributions about psychosis onset in youth, including a subset of first‐episode psychosis patients, and the patient and caregiver characteristics that influence these attributions. It also examines if caregiver views are affected by contact with youth mental health services.Methods: Fifty‐one caregivers of 50 youth patients with a diagnosed Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM‐IV) psychotic disorder were interviewed about their causal attributions. Patient and caregiver demographic and clinical predictors were also collected.Results: Caregivers most highly endorsed substance use, genetics, negative peer influences and school stress as individual causes. These findings were consistent across the total sample. Principal components analysis derived three causal categories. Caregivers most frequently endorsed a biological and substance use lifestyle causal category, followed by psychological vulnerability and stress‐reactivity causal categories. There was evidence that caregiver and patient factors, as well as contact with youth mental health services, influenced the causal attributions caregivers made about the onset of psychosis.Conclusion: Caregivers of youth with psychosis are making causal attributions that are consistent with current aetiological theories of psychosis in youth. The study showed that caregivers are particularly cognizant of genetic and substance use factors in the development and maintenance of psychosis. However, youth mental health services may need to particularly focus on increasing caregiver understanding of the dynamics of stress factors as symptoms, and not causes, of psychosis early in the illness course.
Surgical and implant‐supported fixed prosthetic treatment of a patient with ectodermal dysplasia: a case report
Authors: Al‐Ibrahim Hind A. , Al‐Hadlaq Solaiman M. , Abduljabbar Tariq S. , Al‐Hamdan Khalid S. , Abdin Hassan A. 
Published: January 2012

ABSTRACTEctodermal dysplasia (ED) is a hereditary disorder that affects ectodermal structures. The main clinical oral manifestations of ED include oligodontia and deficient alveolar ridges. This case report presents the oral rehabilitation of a 15‐year‐old female patient who never received an accurate diagnosis or appropriate dental care. Treatment included a combination of surgical intervention, a maxillary tooth‐supported fixed detachable telescopic prosthesis, and an implant‐supported mandibular fixed partial denture. The results showed a significant improvement in the esthetics, function, and psychological status of the patient. This article stresses the importance of appropriate care in providing an acceptable quality of life for patients with ED.
Decrease in oral health may be associated with length of time since beginning dialysis
Authors: Sekiguchi Ricardo Takiy , Pannuti Claudio Mendes , Silva Jr. Helio Tedesco , Medina‐Pestana José Osmar , Romito Giuseppe Alexandre 
Published: January 2012

ABSTRACTThe aim of this study was to evaluate how oral health is affected by the length of time a patient has been receiving hemodialysis (HD) treatment. Ninety‐four subjects participated in this study. Demographic, periodontal parameters, and decayed missing and filled teeth (DMFT) index were recorded by a trained and calibrated examiner. The subjects were divided into two groups: Group L (subjects who had been on HD for less than 36 months), and Group M (those who had been on HD for more than 37 months). In Group M, the mean probing depth was deeper (p= 0.01) and clinical attachment loss was significantly higher (p= 0.02) than subjects in Group L. The DMFT index score was also significantly higher in Group M (p= 0.03). A moderate correlation between length of time on HD and DMFT index, probing depth, and clinical attachment loss was observed. The group of subjects who had been on HD for more than 37 months had more periodontal disease and higher DMFT index scores, suggesting that the length of time on HD could negatively impact oral health.
Dental treatment of patients with systemic diseases compared to patients with developmental disabilities under general anesthesia
Authors: Peretz Benjamin , Spierer Ayala , Spierer Shoshana , Rakocz Meir 
Published: January 2012

ABSTRACTThe medical and dental records were examined for 46 patients with systemic diseases (SD) and 75 patients with developmental disabilities (DD) aged 2–20 years, who had received dental treatment under general anesthesia (GA). Age, gender, decayed missing and filled teeth (dmft/DMFT), dental procedures, duration of GA, and posttreatment hospitalization were recorded. Before treatment, dental disease in the primary teeth was significantly higher among the group with SD (p= 0.04). In the permanent teeth, dental disease was higher among the group with DD, though not significantly. More teeth were restored, (p= 0.015) and total dmft (p= 0.043) was significantly higher among subjects with SD. In the permanent teeth, more extracted and more restored teeth and higher DMFT were noted among subjects with DD, though not significantly. Only pulpectomies were significantly more prevalent among those with DD (p= 0.038). Six subjects needed hospitalization due to their diseases after GA.
Duplication of CXC chemokine genes on chromosome 4q13 in a melanoma‐prone family
Authors: Yang Xiaohong R. , Brown Kevin , Landi Maria T. , Ghiorzo Paola , Badenas Celia , Xu Mai , Hayward Nicholas K. , Calista Donato , Landi Giorgio , Bruno William , Bianchi‐Scarrà Giovanna , Aguilera Paula , Puig Susana , Goldstein Alisa M. , Tucker Margaret A. 
Published: January 2012

SummaryCopy number variations (CNVs) have been shown to contribute substantially to disease susceptibility in several inherited diseases including cancer. We conducted a genome‐wide search for CNVs in blood‐derived DNA from 79 individuals (62 melanoma patients and 17 spouse controls) of 30 high‐risk melanoma‐prone families without known segregating mutations using genome‐wide comparative genomic hybridization (CGH) tiling arrays. We identified a duplicated region on chromosome 4q13 in germline DNA of all melanoma patients in a melanoma‐prone family with three affected siblings. We confirmed the duplication using quantitative PCR and a custom‐made CGH array design spanning the 4q13 region. The duplicated region contains 10 genes, most of which encode CXC chemokines. Among them, CXCL1 (melanoma growth‐stimulating activity α) and IL8 (interleukin 8) have been shown to stimulate melanoma growth in vitro and in vivo. Our data suggest that the alteration of CXC chemokine genes may confer susceptibility to melanoma.