bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distinguishing risk of curve progression in adolescent idiopathic scoliosis with bone microarchitecture phenotyping: a 6-year longitudinal study
Authors: Yang Kenneth Guangpu , Lee Wayne Yuk-Wai , Hung Alec Lik-Hang , Kumar Anubrat , Chui Elvis Chun-Sing , Hung Vivian Wing-Yin , Cheng Jack Chun-Yiu , Lam Tsz-Ping , Lau Adam Yiu-Chung 
Published: June 2024

Abstract
Low bone mineral density and impaired bone quality have been shown to be important prognostic factors for curve progression in adolescent idiopathic scoliosis (AIS). There is no evidence-based integrative interpretation method to analyze high-resolution peripheral quantitative computed tomography (HR-pQCT) data in AIS. This study aimed to (1) utilize unsupervised machine learning to cluster bone microarchitecture phenotypes on HR-pQCT parameters in girls with AIS, (2) assess the phenotypes’ risk of curve progression and progression to surgical threshold at skeletal maturity (primary cohort), and (3) investigate risk of curve progression in a separate cohort of girls with mild AIS whose curve severity did not reach bracing threshold at recruitment (secondary cohort). Patients were followed up prospectively for 6.22 ± 0.33 years in the primary cohort (n = 101). Three bone microarchitecture phenotypes were clustered by fuzzy C-means at time of peripubertal peak height velocity (PHV). Phenotype 1 had normal bone characteristics. Phenotype 2 was characterized by low bone volume and high cortical bone density, and phenotype 3 had low cortical and trabecular bone density and impaired trabecular microarchitecture. The difference in bone quality among the phenotypes was significant at peripubertal PHV and continued to skeletal maturity. Phenotype 3 had significantly increased risk of curve progression to surgical threshold at skeletal maturity (odd ratio [OR] = 4.88; 95% CI, 1.03–28.63). In the secondary cohort (n = 106), both phenotype 2 (adjusted OR = 5.39; 95% CI, 1.47–22.76) and phenotype 3 (adjusted OR = 3.67; 95% CI, 1.05–14.29) had increased risk of curve progression ≥6° with mean follow-up of 3.03 ± 0.16 years. In conclusion, 3 distinct bone microarchitecture phenotypes could be clustered by unsupervised machine learning on HR-pQCT–generated bone parameters at peripubertal PHV in AIS. The bone quality reflected by these phenotypes was found to have significant differentiating risk of curve progression and progression to surgical threshold at skeletal maturity in AIS.
Examining Income Expectations in the College and Early Post-College Periods: New Distributional Tests of Rational Expectations
Authors: Crossley Thomas F , Gong Yifan , Stinebrickner Ralph , Stinebrickner Todd 
Published: June 2024

Abstract
Using unique longitudinal probabilistic expectations data from the Berea Panel Study, which cover both college and early post-college periods, we examine young adults’ beliefs about their future incomes. We introduce two new approaches to testing whether, ex ante, agents exhibit Rational Expectations. We show that taking into account the additional information about higher moments of individual belief distributions contained in probabilistic expectations data reveals violations of Rational Expectations that are not detected by existing mean-based tests. Empirically, we find that our subjects underestimate the level of uncertainty they face about future incomes.
High-precision imaging of small voids in tunnel lining based on reverse time migration
Authors: Ling Tonghua , Jiang Hao , Zhang Liang , Zhang Sheng , Bei Zhenghao , Long Bin 
Published: June 2024

Abstract
Diseases such as voids behind the initial support of the tunnel will lead to problems such as lining rupture and concrete damage in the tunnel structure, which seriously affects the driving safety in the tunnel. In tunnel construction, ground penetrating radar is frequently employed as a method for detecting hidden defects. However, when the cavity size is small, there will be a large error when the original radar data is directly interpreted, which cannot meet the needs of practical engineering. To enhance the precision in tunnel detection, the Finite-Difference Time-Domain method is used to simulate various small cavities of different shapes located behind the primary support lining of the tunnel, and the study involves examining the electromagnetic response characteristics of different kinds of holes. The migration techniques of KIRCHHOFF, F-K, and reverse time are employed to reconstruct the hole target. Furthermore, digital morphology is employed to enhance the clarity of the image. Finally, the edge detection technology is used to further extract the hole features. After that, small cavities of different shapes are buried in the established outdoor concrete model box and radar detection is carried out. The detection position of the reconstructed radar image and the actual position of the cavity in the model box are verified. The results show that compared with KIRCHHOFF migration and F-K migration, the image processed by reverse time migration is clearer and more intuitive, and can restore the contour of small holes well. The research findings can serve as a reference for the interpretation of radar data of the cavity behind the initial support of the tunnel.
Disentangling genetic diversity of Myotis septentrionalis: population structure, demographic history, and effective population size
Authors: Grimshaw Jenna R , Donner Deahn , Perry Roger , Ford W Mark , Silvis Alex , Garcia Carlos J , Stevens Richard D , Ray David A 
Published: June 2024

Abstract
Myotis septentrionalis (Northern Long-eared Bat) has recently suffered a &gt;90% decline in population size in North America due to white-nose syndrome (WNS). We assessed genetic diversity, population structure, current effective population size, and demographic history of M. septentrionalis distributed across the United States to determine baseline levels pre-WNS. We analyzed RADseq data from 81 individuals from Kentucky, Louisiana, Michigan, Minnesota, North Carolina, Oklahoma, and Wisconsin. Additionally, we examined population genetic structure using discriminant analysis of principal components, fastStructure, and STRUCTURE. We then estimated effective population size and demographic history using fastsimcoal2. Similar levels of genetic diversity were found across all samples. We found no population genetic structure in the varied analyses from these contemporary samples. The best model for demographic history estimated a rapid population expansion followed by a slower expansion approximately 340,000 years ago. The vagility of M. septentrionalis, along with male dispersal and random mating, may provide a buffer against serious bottleneck effects stemming from rapid population declines due to WNS. This research provides a baseline for tracking and monitoring the influence of WNS on genetic diversity such as potential reduced diversity or increased population structuring in the future.
Examining evidence of lung cancer stigma among health-care trainees
Authors: Studts Jamie L , Deffendall Catherine M , McCubbin Shelby L , Hamann Heidi A , Hoover Kaitlyn , Brymwitt Whitney M , Williamson Timothy J 
Published: June 2024

Abstract

Background
Innovations in lung cancer control and care have started to transform the landscape of lung cancer outcomes, but lung cancer stigma and biases have been implicated as a deterrent to realizing the promise of these innovations. Research has documented lung cancer stigma among the general public and lung cancer survivors (self-blame), as well as clinicians across many disciplines. However, studies have not explored lung cancer stigma in health-care trainees. These data seek to address that gap and inform efforts to prevent the emergence or mitigate the presence of lung cancer stigma among future clinicians.

Methods
Using clinical vignettes and a 2x2 factorial design, this investigation evaluated the impact of a history of smoking (yes vs no) and cancer diagnosis (lung vs colorectal) on perceptions of the described patient among 2 groups of preclinical health-care trainees (medical = 94 and nursing = 138). A charitable giving paradigm also asked participants to donate provided funds to 1 of 2 cancer advocacy organizations: one serving the lung cancer community and one serving the colorectal cancer community.

Results
In study 1, results revealed a consistent pattern of statistically significant and medium to large effect size differences regarding stigmatized perceptions (eg, higher stigmatizing behavior, increased pity, greater anger, and less helping) for individuals with a history of smoking but no reliable differences regarding cancer diagnosis. Analysis of data from nursing trainees in study 2 showed a similar pattern of statistically significant and medium to large effects pertaining to stigma behavior and perceptions of individuals who had a history of smoking depicted in the vignettes. The charitable giving paradigm did not identify any reliable difference between the groups in either study.

Conclusions
Findings revealed a consistent pattern of health-care trainee perceptions that varied by smoking status but much less evidence that the cancer diagnosis contributed to different perceptions. This suggests that efforts to integrate consideration of stigma and biases in health-care training needs to adopt an approach that seeks to mitigate or eliminate stigmatizing perceptions and behaviors toward individuals with a history of smoking.
Cancer stigma: the need for policy and programmatic action
Authors: Johnson Sonali Elizabeth , Samson Mélanie 
Published: June 2024

Abstract
Cancer is a stigmatized disease in many countries that impacts the quality of life and mental health of people affected by cancer. This commentary examines some dimensions of cancer stigma and has been developed based on insights from participants in a Union for International Cancer Control program dedicated to cancer patient organizations in low- and middle-income countries. Aimed at program managers and policy makers, this commentary highlights the importance of developing strategies to reduce cancer stigma in cancer control programs in different contexts, working closely with community-based civil society organizations and those with lived experience of cancer to understand, evaluate, and take action regarding the impact of cancer stigma on health-seeking behavior and patients’ quality of life.
Impact of a multicomponent navigation strategy on stigma among people living with HIV and Kaposi’s sarcoma in Kenya: a qualitative analysis
Authors: Collier Sigrid M , Semeere Aggrey , Chemtai Linda , Byakwaga Helen , Lagat Celestine , Laker-Oketta Miriam , Bramante Juliet , Pacheco Ann , Zehtab Morvarid , Strahan Alexis G , Grant Merridy , Bogart Laura M , Bassett Ingrid V , Busakhala Naftali , Opakas Jesse , Maurer Toby , Martin Jeffrey , Kiprono Samson , Freeman Esther E 
Published: June 2024

Abstract
Persons with HIV-associated Kaposi’s sarcoma (KS) experience three co-existing stigmatizing health conditions: skin disease, HIV, and cancer, which contribute to a complex experience of stigmatization and to delays in diagnosis and treatment. Despite the importance of stigma among these patients, there are few proven stigma-reduction strategies for HIV-associated malignancies. Using qualitative methods, we explore how people with HIV-associated KS in western Kenya between August 2022 and 2023 describe changes in their stigma experience after participation in a multicomponent navigation strategy, which included 1) physical navigation and care coordination, 2) video-based education with motivational survivor stories, 3) travel stipend, 4) health insurance enrollment assistance, 5) health insurance stipend, and 6) peer mentorship. A purposive sample of persons at different stages of chemotherapy treatment were invited to participate. Participants described how a multicomponent navigation strategy contributed to increased knowledge and awareness, a sense of belonging, hope to survive, encouragement, and social support, which served as stigma mitigators, likely counteracting the major drivers of intersectional stigma in HIV-associated KS.
Exploring a distinct FGFR2::DLG5 rearrangement in a low-grade neuroepithelial tumor: A case report and mini-review of protein fusions in brain tumors
Authors: Loreto Palacio Paola , Pan Xiaokang , Jones Dan , Otero José Javier 
Published: June 2024

Abstract
We report the novel clinical presentation of a primary brain neoplasm in a 30-year-old man with a mass-like area in the anteromedial temporal lobe. Histopathological analysis revealed a low-grade neuroepithelial tumor with cytologically abnormal neurons and atypical glial cells within the cerebral cortex. Molecular analysis showed a previously undescribed FGFR2::DLG5 rearrangement. We discuss the clinical significance and molecular implications of this fusion event, shedding light on its potential impact on tumor development and patient prognosis. Additionally, an extensive review places the finding in this case in the context of protein fusions in brain tumors in general and highlights their diverse manifestations, underlying molecular mechanisms, and therapeutic implications.
The Verbal System of Baritle Neo-Aramaic
Authors: Al-Saka Vean 
Published: June 2024

Abstract
This paper presents a comprehensive study of verbal inflection in the Neo-Aramaic dialect of Baritle (northern Iraq). Similar to other Semitic languages, Baritle uses ‘root and pattern’ morphology and verb roots are generally triliteral. Whereas the core structures of the Baritle verb system align with those found in other North-Eastern Neo-Aramaic languages, Baritle exhibits distinctive variations in several noteworthy aspects. This study of the verbal inflection of Baritle identifies the inflections by number and type. It finds that the verb in Baritle has different functional categories indicating tense, aspect, and mood. It also finds that the verb has various bound pronominals representing the grammatical categories of person, number, and gender of its arguments. This paper documents an endangered language and contributes to the typology of the grammar of natural languages.
A Morphological Reconstruction of T-Stems in Proto-Semitic
Authors: Mellison John 
Published: June 2024

Abstract
A central morphological feature of Semitic languages is the so-called ‘t-stems’ associated with the G, D and C stems. These forms attach a /t/ to the verbal root and often convey reflexive, reciprocal, or mediopassive action. The Semitic languages attest a puzzling mix of prefixed and infixed t-stem forms, and thus it has been challenging to reconstruct the original Proto-Semitic (PS) structure. The general consensus is that PS prefixed the /t/ to the root and the daughter languages underwent a series of complex phonological changes. This study argues that the /t/ was infixed in the G-stem and prefixed in the D-stem in PS. This reconstruction easily accounts for the variety of forms attested in the Semitic languages and only requires paradigm levelling in one stem to account for the attested variety. I argue this by raising problems with the consensus view and presenting inscriptional evidence of systemwide levelling in Northwest Semitic.
Who wrote the first Constitutions of Freemasonry?
Authors: Péter Róbert , Jawerbaum Alejandro Napolitano 
Published: June 2024

Abstract
This article addresses the problematic authorship of The Constitutions of the Free-Masons (1723). Traditionally associated with James Anderson, using stylometry, we examine whether and, if so, where John T. Desaguliers, the prime mover of early English institutionalized Freemasonry, contributed to this publication. Our corpus includes writings by Anderson, Desaguliers, and two contemporary Freemasons used as distractors. The transcribed works contain texts from different genres and of varying lengths. In our methodology, we employ a wide range of robust, multivariate, unsupervised, and cross-validated supervised tests, verified through significance testing, which can hopefully contribute to the establishment of standards for historical authorship attribution. Our results suggest, in line with historical evidence, that the legendary history of the Constitutions was most likely primarily authored by Anderson. However, several of the Charges including the first one ‘Concerning God and religion’, one of the most disputed texts in the history of Freemasonry, are closer to the style of Desaguliers. The General Regulations concerning the organization of the lodges, hitherto attributed to George Payne, played a fundamental role in spreading Freemasonry worldwide. Our analyses show that the stylistic affinity of fifteen of the thirty-nine regulations has a pronounced closeness to Anderson’s style, five align more closely with Desaguliers’ style. The authorship of the rest remains inconclusive partly due to the insufficient length of texts by Payne. These novel findings are also supported by a close reading of the Constitutions and other contemporary primary sources.
Gravitational wave emission from close-in strange quark planets around strange stars with magnetic interactions
Authors: Zhang Xiao-Li , Zou Ze-Cheng , Huang Yong-Feng , Gao Hao-Xuan , Wang Pei , Cui Lang , Liu Xiang 
Published: June 2024

ABSTRACT
According to the strange quark matter hypothesis, strange planets may exist, which are planetary mass objects composed of almost equal numbers of up, down, and strange quarks. A strange planet can revolve around its host strange star in a very close-in orbit. When it finally merges with the host, strong gravitational wave emissions will be generated. Here, the gravitational waveforms are derived for the merging process, taking into account the effects of the strange star’s magnetic field on the dynamics. Effects of the inclination angle are also considered. Templates of the gravitational waveforms are derived. It is found that the magnetic interactions significantly speed up the merging process. Coalescence events of such strange planetary systems occurring in our Galaxy as well as in local galaxies can be effectively detected by current and future gravitational experiments, which may hopefully provide a new method to test the strange quark matter hypothesis and probe the magnetic field of compact stars.
Complete response to capmatinib in a patient with metastatic lung adenocarcinoma harboring CD47-MET fusion: a case report
Authors: Alves de Souza Glaucia , Dornellas Debora Maciel Santana , Campregher Paulo Vidal , Teixeira Carlos Henrique Andrade , Schvartsman Gustavo 
Published: June 2024

Abstract
Comprehensive genomic profiling is highly recommended for treatment decision in nonsquamous, non-small cell lung cancer (NSCLC). However, rare genomic alterations are still being unveiled, with scarce data to guide therapy. Herein, we describe the treatment journey of a 56-year-old, never-smoker Caucasian woman with a metastatic NSCLC harboring a CD47-MET fusion, initially classified as a variant of unknown significance. She had undergone 3 lines of therapy over the course of 3 years, including chemotherapy, immunotherapy, and anti-angiogenic therapy. After reanalysis of her next-generation sequencing data in our service, the fusion was reclassified as likely oncogenic. The patient was started with fourth-line capmatinib, with a good tolerance so far and a complete metabolic response in the active sites of disease, currently ongoing for 18 months. In conclusion, we highlight the sensitivity of a novel MET fusion to capmatinib and emphasize the need for comprehensive panels in NSCLC and molecular tumor board discussions with specialized centers when rare findings arise.
Phase 2 study of pegylated liposomal doxorubicin plus cyclophosphamide, vincristine/vindesine, and prednisone in newly diagnosed PTCL: 8-year results
Authors: Xia Zu-Guang , Lv Fang-Fang , Zhang Qun-Ling , Liu Yi-Zhen , Zhang Sheng-Jian , Liu Chang , Li Xiao-Qiu , Wen Yu , Wu Zhen-Yu , Hong Xiao-Nan , Guo Ye , Cao Jun-Ning 
Published: June 2024

Abstract

Background
Pegylated liposomal doxorubicin (PLD) is a liposome-encapsulated form of doxorubicin with equivalent efficacy and less cardiotoxicity. This phase 2 study evaluated the efficacy and safety of the PLD-containing CHOP regimen in newly diagnosed patients with aggressive peripheral T-cell lymphomas (PTCL).

Methods
Patients received PLD, cyclophosphamide, vincristine/vindesine, plus prednisone every 3 weeks for up to 6 cycles. The primary endpoint was the objective response rate at the end of treatment (EOT).

Results
From September 2015 to January 2017, 40 patients were treated. At the EOT, objective response was achieved by 82.5% of patients, with 62.5% complete response. As of the cutoff date (September 26, 2023), median progression-free survival (mPFS) and overall survival (mOS) were not reached (NR). The 2-year, 5-year, and 8-year PFS rates were 55.1%, 52.0%, and 52.0%. OS rate was 80.0% at 2 years, 62.5% at 5 years, and 54.3% at 8 years. Patients with progression of disease within 24 months (POD24) had worse prognosis than those without POD24, regarding mOS (41.2 months vs NR), 5-year OS (33.3% vs 94.4%), and 8-year OS (13.3% vs 94.4%). Common grade 3-4 adverse events were neutropenia (87.5%), leukopenia (80.0%), anemia (17.5%), and pneumonitis (17.5%).

Conclusion
This combination had long-term benefits and manageable tolerability, particularly with less cardiotoxicity, for aggressive PTCL, which might provide a favorable benefit-risk balance.

ClinicalTrials.gov Identifier
Chinese Clinical Trial Registry, ChiCTR2100054588; IRB Approved: Ethics committee of Fudan University Shanghai Cancer Center (Date 2015.8.31/No. 1508151-13.
Colorectal cancer harboring EGFR kinase domain duplication response to EGFR tyrosine kinase inhibitors
Authors: Kondo Tomohiro , Kikuchi Osamu , Yamamoto Yoshihiro , Sunami Tomohiko , Wang Yafeng , Fukuyama Keita , Saito Tomoki , Nakahara Hideto , Minamiguchi Sachiko , Kanai Masashi , Sueyoshi Atsushi , Muto Manabu 
Published: June 2024

Abstract
Epidermal growth factor receptor kinase domain duplication (EGFR-KDD) is a rare, recurrent oncogenic variant that constitutively activates EGFR in non-small-cell lung cancer. Herein, we report the case of a 70-year-old man with resectable colorectal adenocarcinoma who underwent surgery followed by adjuvant therapy. He relapsed with multiple liver metastases and received standard chemotherapy until his disease became refractory. Comprehensive genomic profiling of his postoperative colorectal cancer tissue revealed EGFR-KDD. He was treated with an EGFR tyrosine kinase inhibitor (TKI), afatinib and achieved a partial response (− 55%) after 8 weeks; however, he developed massive malignant ascites after 13 weeks. Osimertinib, another EGFR-TKI, controlled his tumors for 9 months. Patient-derived cancer organoids from his malignant ascites confirmed sensitivity to EGFR-TKIs. The findings suggest that EGFR-TKIs can be a potential treatment option for this molecular subgroup.