bluuebunny/crossref_metadata_2025_split huggingface dataset:
Specific DNA Duplex Formation at an Artificial Lipid Bilayer: towards a New DNA Biosensor Technology
Authors: Werz Emma , Korneev Sergei , Montilla‐Martinez Malayko , Wagner Richard , Hemmler Roland , Walter Claudius , Eisfeld Jörg , Gall Karsten , Rosemeyer Helmut 
Published: February 2012

AbstractA novel technique is described which comprises a base‐specific DNA duplex formation at a lipid bilayerH2O‐phase boundary layer. Two different probes of oligonucleotides both carrying a double‐tailed lipid at the 5′‐terminus were incorporated into stable artificial lipid bilayers separating two compartments (cis/trans‐channel) of an optically transparent microfluidic sample carrier with perfusion capabilities. Both the cis‐ and trans‐channels are filled with saline buffer. Injection of a cyanine‐5‐labeled target DNA sequence, which is complementary to only one of the oligonucleotide probes, into the cis‐channel, followed by a thorough perfusion, leads to an immobilization of the labeled complementary oligonucleotide on the membrane as detected by single‐molecule fluorescence spectroscopy and microscopy. In the case of fluorescent but non‐complementary DNA sequences, no immobilized fluorescent oligonucleotide duplex could be detected on the membrane. This clearly verifies a specific duplex formation at the membrane interface.
Oligoethylene Glycols as Highly Efficient Mutifunctional Promoters for Nucleophilic‐Substitution Reactions
Authors: Jadhav Vinod H. , Jang Seung Ho , Jeong Hwan‐Jeong , Lim Seok Tae , Sohn Myung‐Hee , Kim Ju‐Young , Lee Sungyul , Lee Ji Woong , Song Choong Eui , Kim Dong Wook 
Published: February 2012

AbstractHerein, we report the promising use of n‐oligoethylene glycols (oligoEGs) as mutifunctional promoters for nucleophilic‐substitution reactions employing alkali metal salts. Among the various oligoEGs tested, pentaethylene glycol (pentaEG) had the most efficient catalytic activity. In particular, when compared with other nucleophiles examined, a fluorine nucleophile generated from CsF was significantly activated by the pentaEG promoter. We also performed various facile nucleophilic‐displacement reactions, such as the halogenation, acetoxylation, thioacetoxylation, nitrilation, and azidation of various substrates with potassium halides, acetate, thioacetate, cyanide, and sodium azide, respectively, in the presence of the pentaEG promoter. All of these reactions provided their desired products in excellent yields. Furthermore, the combination of pentaEG and a tert‐alcohol medium showed tremendous efficiency in the nucleophilic‐displacement reactions (fluorination and methoxylation) of base‐sensitive substrates with basic nucleophiles (cesium fluoride and potassium methoxide, respectively). The catalytic role of oligoEGs was examined by quantum‐chemical methods. The oxygen atoms in oligoEGs were found to act as Lewis bases on the metal cations to produce the “flexible” nucleophile, whereas the two terminal hydroxy (OH) groups acted as “anchors” to orientate the nucleophile and the substrate into an ideal configuration for the reaction.
ChemInform Abstract: Structures of the Strontium and Barium Dodecahydro‐closo‐dodecaborates.
Authors: Her Jae‐Hyuk , Wu Hui , Verdal Nina , Zhou Wei , Stavila Vitalie , Udovic Terrence J. 
Published: February 2012

AbstractThe structures of SrB12H12 and BaB12H12 are determined by X‐ray and neutron powder diffraction, neutron vibrational spectroscopy, and DFT calculations.
ChemInform Abstract: Frustrated Magnetism in the S = 1 Kagome Lattice BaNi3(OH)2(VO4)2.
Authors: Freedman Danna E. , Chisnell Robin , McQueen Tyrel M. , Lee Young S. , Payen Christophe , Nocera Daniel G. 
Published: February 2012

AbstractThe new two‐dimensional magnetically frustrated title compound is synthesized from an aqueous NH4OH solution containing Ni(OH)2, V2O5, an Ba(OAc)2 (reflux, 4 h).
ChemInform Abstract: Pb2.85Ba2.15Fe4SnO13: A New Member of the AnBnO3n‐2 Anion‐Deficient Perovskite‐Based Homologous Series.
Authors: Korneychik Oleg E. , Batuk Maria , Abakumov Artem M. , Hadermann Joke , Rozova Marina G. , Sheptyakov Denis V. , Pokholok Konstantin V. , Filimonov Dmitry S. , Antipov Evgeny V. 
Published: February 2012

AbstractThe title compound is synthesized by solid state reaction of PbO, BaCO3, Fe2O3, and SnO2 in air (850 °C for 50 h and 900, 950, and 980 °C for 10 h each).
ChemInform Abstract: BaSn6Co6O19 — A Novel Frustrated Antiferromagnet with the Magnetoplumbite Type Structure.
Authors: Shlyk L. , Niewa R. 
Published: February 2012

AbstractSingle crystals of the new title compound are prepared by reaction of SnO2, Co3O4, and excess BaCl2 acting as reactive flux (1320 °C, several days).
ChemInform Abstract: A Novel Sandwich‐Type Europium‐Substituted Germanomolybdate Linked with Coordination Cation [Cu(en)2]2+.
Authors: Yang Lan‐Jun , Xu Lin , Li Feng‐Yan , Wang Yu‐Chao , Xu Bing‐Bing 
Published: February 2012

AbstractThe structure of title compound (V) is determined by single crystal XRD (triclinic, space group P$\bar 1$, Z = 1).
ChemInform Abstract: Structure and Properties of Rhombohedral CePd3Ga8: A Variant of the Cubic Parent Compound with BaHg11 Structure Type.
Authors: Macaluso Robin T. , Francisco Melanie , Young David P. , Stadler Shane , Mitchell John F. , Geiser Urs , Hong Han‐yul , Kanatzidis Mercouri G. 
Published: February 2012

AbstractSingle crystals of the new title compound are prepared from the elements using excess gallium as a flux (alumina crucible, 1150 °C, 2 h, 80—90% yield).
ChemInform Abstract: Palladium on Carbon‐Catalyzed Solvent‐Free and Solid‐Phase Hydrogenation and Suzuki—Miyaura Reaction.
Authors: Monguchi Yasunari , Fujita Yuki , Hashimoto Shota , Ina Mariko , Takahashi Tohru , Ito Ryo , Nozaki Kei , Maegawa Tomohiro , Sajiki Hironao 
Published: February 2012

AbstractSolvent‐free Pd—C‐catalyzed hydrogenation of a diversity of reducible functionalities, e.g. benzyl ethers and esters, multiple C—C bonds, alcohols, aromatic chloride, N‐Cbz, nitro, and azido groups, is presented.
ChemInform Abstract: Selective 1:2 Coupling of Aldehydes and Allenes with Control of Regiochemistry.
Authors: Toyoshima Takeharu , Miura Tomoya , Murakami Masahiro 
Published: February 2012

AbstractThe rhodium‐catalyzed title reaction affords either of two constitutional isomers of β,γ‐dialkylidene ketones as main product.
ChemInform Abstract: Catalytic Syntheses of N‐Heterocyclic Ynones and Ynediones by in situ Activation of Carboxylic Acids with Oxalyl Chloride.
Authors: Boersch Christina , Merkul Eugen , Mueller Thomas J. J. 
Published: February 2012

AbstractStarting from α‐keto carboxylic acids, the glyoxylyl chlorides generated in situ by reaction with oxalyl chloride are transformed under Castro conditions into ynediones.
ChemInform Abstract: Glycerol as an Alternative Green Reaction Medium for Multicomponent Reactions Using PS‐PEG‐OSO3H as Catalyst.
Authors: Quan Zheng‐Jun , Ren Rong‐Guo , Da Yu‐Xia , Zhang Zhang , Wang Xi‐Cun 
Published: February 2012

AbstractFor the first time different multicomponent reactions are operated in glycerol as reaction medium and in the presence of polystyrene‐PEG resin‐supported sulfuric acid as catalyst.
ChemInform Abstract: Facile, Environmentally Friendly Synthesis of Benzaldehyde and Phenylacetaldehyde Analogues from Readily Available Toluene Derivatives.
Authors: Dai Liyan , Yu Jie , Chen Yingqi , Yu Shichao 
Published: February 2012

AbstractThe title compounds (II) and (IV) are formed via oxidation and hydrolysis, resp., of intermediate styrylamines.
ChemInform Abstract: Palladium‐Catalyzed Amidation of N‐Tosylhydrazones with Isocyanides.
Authors: Zhou Fengtao , Ding Ke , Cai Qian 
Published: February 2012

AbstractThe Pd‐catalyzed aminocarbonylation of carbenes, in situ generated from N‐tosylhydrazones, with isocyanides represents a novel access towards carboxylic amides, e.g. (III), (V), (VIII) and (X).
ChemInform Abstract: An Efficient and Simple Protocol for a PdCl2‐Ligandless and Additive‐Free Suzuki Coupling Reaction of Aryl Bromides.
Authors: Qiu Jun , Wang Limin , Liu Mingtao , Shen Qiang , Tang Jun 
Published: February 2012

AbstractThe reaction is amenable to a diversity of functionalized substrates under mild reaction conditions.
ChemInform Abstract: Synthesis and Structures of a Series of Bulky “Rind‐Br” Based on a Rigid Fused‐Ring s‐Hydrindacene Skeleton.
Authors: Matsuo Tsukasa , et al. et al. 
Published: February 2012

AbstractA variety of octasubstituted s‐hydrindacenyl bromides is prepared by BCl3‐catalyzed intramolecular Friedel—Crafts reaction of appropriate dichlorides followed by bromination or vice versa.
ChemInform Abstract: Transforming Terpene‐Derived Aldehydes into 1,2‐Epoxides via Asymmetric α‐Chlorination: Subsequent Epoxide Opening with Carbon Nucleophiles.
Authors: Winter Philipp , Swatschek Joerg , Willot Matthieu , Radtke Lea , Olbrisch Tobias , Schaefer Andreas , Christmann Mathias 
Published: February 2012

AbstractA practical protocol for the conversion of aldehydes (I) into terminal epoxides (II) via an organocatalytic asymmetric enamine chlorination is described.
ChemInform Abstract: An Efficient Direct Asymmetric Synthesis of 3‐Substituted Phthalides.
Authors: Zhang Zhan‐Bin , Lu Yong‐Qin , Duan Xin‐Fang 
Published: February 2012

AbstractA facile two‐step asymmetric synthesis of target compounds (V) is achieved using L‐proline‐derived amine base (I) as chiral template and magnesiation with iPr‐MgCl.
ChemInform Abstract: Metal‐Free Oxidative Coupling Reactions via σ‐Iodonium Intermediates: The Efficient Synthesis of Bithiophenes Using Hypervalent Iodine Reagents.
Authors: Morimoto Koji , Nakae Tomofumi , Yamaoka Nobutaka , Dohi Toshifumi , Kita Yasuyuki 
Published: February 2012

AbstractDirect oxidative dimerization of thiophene derivatives bearing electron‐donating substituents at position 3 and 4 proceeds readily in the presence of a hypervalent iodine reagent (HTIB).
ChemInform Abstract: Thienopyrrolyl Dione End‐Capped Oligothiophene Ambipolar Semiconductors for Thin Film‐ and Light Emitting Transistors.
Authors: Melucci Manuela , Zambianchi Massimo , Favaretto Laura , Gazzano Massimo , Zanelli Alberto , Monari Magda , Capelli Raffaella , Troisi Stefano , Toffanin Stefano , Muccini Michele 
Published: February 2012

AbstractTarget compound (V) is alternatively prepared via Stille coupling of bromo thiophene (I) with 5,5′‐bis(tributylstannyl)‐2,2′‐bithiophene.
ChemInform Abstract: Synthesis of Novel Chiral Unsymmetrical Imidazolinium Bromides.
Authors: Yang Longguang , Sun Rui , Zhang Lingqiao , Li Yunfei , Cao Changsheng , Pang Guangsheng , Shi Yanhui 
Published: February 2012

AbstractA series of the title compounds (VI), precusors of N‐heterocyclic carbenes, is efficiently obtained under mild reaction conditions starting from L‐phenylalanine.
ChemInform Abstract: Phosphite‐Mediated Synthesis of Benzimidazoles: A One‐Pot Four‐Component Approach from Nitrophenols.
Authors: El Kaim Lurent , Grimaud Laurence , Purumandla Srinivas Reddy 
Published: February 2012

AbstractPhosphite‐triggered reductive cyclization of Ugi—Smiles adducts is successfully applied to the synthesis of benzimidazoles (V).
ChemInform Abstract: Synthesis of 2‐(3‐Phenoxyphenyl)‐substituted Benzoxazoles, Based on Nitriles Containing the Diphenyl Oxide Fragment.
Authors: Popov Yu. V. , Korchagina T. K. , Lobasenko V. S. 
Published: February 2012

AbstractThe title compounds are of interest as structural building blocks for the synthesis of compounds possessing potential biological activity.
ChemInform Abstract: New Fluorescent 2‐(5‐Acetoacetyl‐2‐furyl)‐benzazoles (III) with Prochiral Methylene Group Protons
Authors: Aleksandrov A. A. , Elchaninov M. M. , Makarova N. I. , Lukyanov B. S. 
Published: February 2012

Abstractsynthesis and characterization
ChemInform Abstract: Reaction of 2‐(Trifluoromethyl)chromones with Cyanoacetamides, Ethyl Cyanoacetate and Diethyl Malonate. Unexpected Synthesis of Benzo[c]coumarin Derivatives.
Authors: Sosnovskikh Vyacheslav Ya. , Safrygin Alexander V. , Anufriev Viktor A. , Eltsov Oleg S. , Iaroshenko Viktor O. 
Published: February 2012

AbstractReaction of chromones (I) with ethyl cyanoacetate or diethyl malonate gives unexpected benzo[c]coumarin derivatives (III) and (V).
ChemInform Abstract: Pyridine Synthesis from Oximes and Alkynes via Rhodium(III) Catalysis: Cp* and Cpt Provide Complementary Selectivity.
Authors: Hyster Todd K. , Rovis Tomislav 
Published: February 2012

AbstractThe synthesis of pyridines, e.g. (III)/(IV) from readily available α,β‐unsaturated oximes such as (I) and alkynes (II) under mild conditions using Rh(III) catalysis is developed.
ChemInform Abstract: Synthesis, Characterization and Photoluminescent Properties of Quinoline Derivatives Containing Both a Biphenyl Group and an α,β‐Diarylacrylonitrile Unit.
Authors: Li Qian , Xu Zhaozhe , Yu Mingxin , Fan Hong , Li Bogeng 
Published: February 2012

AbstractThe compounds emit blue to green fluorescence in solution and in the solid state under UV irradiation.
ChemInform Abstract: One‐Pot Synthesis of N2‐Substituted 2‐Amino‐4‐aryl‐5,6,7,8‐tetrahydroquinoline‐3‐carbonitrile in Basic Ionic Liquid [bmim]OH.
Authors: Wan Yu , Yuan Rui , Zhang Fu‐Ren , Pang Li‐Ling , Ma Rui , Yue Cai‐Hui , Lin Wei , Yin Wei , Bo Rong‐Cheng , Wu Hui 
Published: February 2012

AbstractThis is the first method using low‐activity cyclohexanone as starting material to synthesize the targeted structure.
ChemInform Abstract: A Novel Series of (S)‐2,7‐Substituted‐1,2,3,4‐tetrahydroisoquinoline‐3‐carboxylic Acids: Peroxisome Proliferator‐Activated Receptor α/γ Dual Agonists with Protein‐Tyrosine Phosphatase 1B Inhibitory Activity.
Authors: Otake Kazuya , Azukizawa Satoru , Fukui Masaki , Shibabayashi Michiko , Kamemoto Hikaru , Miike Tomohiro , Kunishiro Kazuyoshi , Kasai Masayasu , Shirahase Hiroaki 
Published: February 2012

AbstractCompound (I) is proven to be more efficacious and safer as an antidiabetic drug than rosiglitazone in mice, which may be due to its PTP‐1B inhibitory activity.
ChemInform Abstract: Synthesis and Antibacterial Activity of Unsaturated Pyrimidine Carboacyclonucleoside Analogues.
Authors: Krim Jamal , Sillahi Bouchra , Taourirte Moha , Eddarir Said , Engels Joachim W. 
Published: February 2012

AbstractThe members of title series (V) show no antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa, but some of them exhibit good activity against Enterococcus hirae strains (MIC = 27 μg/ml) and E.
ChemInform Abstract: Biginelli‐Like Cyclocondensation Reaction: Efficient Synthesis of 4,6‐Diarylpyrimidin‐2(1H)‐one under Solvent‐Free Conditions.
Authors: Dai Yisi , Cao Minxiang , Zhuang Mengjie , Xia Sheng , Tu Shujiang , Rong Liangce 
Published: February 2012

AbstractA new synthetic access to 4,6‐diarylpyrimidin‐2(1H)‐ones (IV) using a Biginelly‐like three‐component reaction is described.
ChemInform Abstract: New 9‐Methyl‐8‐(4‐hydroxyphenyl)adenine Derivatives as A1 Adenosine Receptor Antagonists.
Authors: Lambertucci Catia , Buccioni Michela , Cacciari Barbara , Dal Ben Diego , Federico Stephanie , Klotz Karl‐Norbert , Marucci Gabriella , Volpini Rosaria , Spalluto Giampiero , Cristalli Gloria 
Published: February 2012

AbstractThe synthesis of a series of 9‐methyladenines bearing bulky groups at the 8‐position and evaluations of their affinity for the four human adenosine receptor subtypes are presented.
ChemInform Abstract: Effective Promotion of Beirut Reaction by β‐Cyclodextrin in Water.
Authors: Sun Tao , Zhao Wen‐Jing , Hao Ai‐You , Sun Li‐Zhen 
Published: February 2012

AbstractFor the first time the Beirut reaction is carried out under supramolecular catalysis in water as environmentally benign solvent.
ChemInform Abstract: Asymmetric Synthesis and Biological Evaluation of N‐Cyclohexyl‐4‐ [1‐(2,4‐dichlorophenyl)‐1‐(p‐tolyl)methyl]piperazine‐1‐carboxamide as hCB1 Receptor Antagonists.
Authors: Gao Linghuan , Li Min , Meng Tao , Peng Hongli , Xie Xin , Zhang Yongliang , Jin Yu , Wang Xin , Zou Libo , Shen Jingkang 
Published: February 2012

AbstractTwo enantiomers of the most potent racemic compounds in a series of recently discovered benzhydrylpiperazines are prepared using the Davis‐Ellmann‐type sulfonamide chemistry.
ChemInform Abstract: Synthesis and Anticandidal Activity of New Triazolothiadiazine Derivatives.
Authors: Altintop Mehlika Dilek , Kaplancikli Zafer Asim , Turan‐Zitouni Guelhan , Oezdemir Ahmet , Iscan Goekalp , Akalin Guelsen , Yildirim Safak Ulusoylar 
Published: February 2012

AbstractFrom the new triazolothiadiazine derivatives (III), compound (IIId) is found to be the most potent derivative against Candida albicans.
ChemInform Abstract: Design, Synthesis, and Insecticidal Activity of 1,5‐Diphenyl‐1‐pentanone Analogues.
Authors: Yang Shaoxiang , Kang Tieniu , Rui Changhui , Yang Xinling , Sun Yufeng , Cui Zining , Ling Yun 
Published: February 2012

AbstractAll compounds were tested against Aphis gossypii, Plutella xylostella, and Tetranychus cinnabarinus.
ChemInform Abstract: The Chemistry of Indoles. Part 138. A Novel Synthesis of 3,4,5,6‐Tetrahydro‐7‐hydroxy‐1H‐azepino[5,4,3‐cd]indole Derivatives from Serotonin.
Authors: Yamada Koji , Teranishi Sakiko , Miyashita Ayako , Ishikura Minoru , Somei Masanori 
Published: February 2012

AbstractNovel substituted serotonins (IV) are used for the synthesis of similarly new azepino[5,4,3‐cd]indoles (VI).
ChemInform Abstract: Furan Ring Opening—Pyrrole Ring Closure: A New Route to Pyrrolo[1,2‐d][1,4]benzodiazepin‐6‐ones.
Authors: Nevolina Tatyana A. , Shcherbinin Vitaly A. , Serdyuk Olga V. , Butin Alexander V. 
Published: February 2012

AbstractThe synthesis of title compounds (V) is based on the catalyzed recyclization of substrates (IV).
ChemInform Abstract: Synthesis of Dibenzo[b,e][1,4]diazepine Derivatives.
Authors: El‐Shaieb Kamal M. , Hassan Alaa A. , Abdel‐Aal Amal S. 
Published: February 2012

AbstractA simple and convenient one‐pot method for the synthesis of the title compounds (III) (8 examples) is developed.
ChemInform Abstract: Discovery of Histone Deacetylase 8 Selective Inhibitors.
Authors: Tang Weiping , Luo Tuoping , Greenberg Edward F. , Bradner James E. , Schreiber Stuart L. 
Published: February 2012

AbstractA library of small molecule inhibitors of histone deacetylase is prepared by coupling of macrocyclic aldehydes such as (VII) with bifunctional hydrazide reagents.
ChemInform Abstract: Sodium in Liquid Ammonia — A Versatile Tool in Modifications of Arylphosphine Oxides.
Authors: Stankevic Marek , Wlodarczyk Adam , Jaklinska Magdalena , Parcheta Renata , Pietrusiewicz K. Michal 
Published: February 2012

AbstractThe reaction of tertiary arylphosphine oxides with sodium in liquid ammonia is strongly influenced by the substrate structure.
ChemInform Abstract: Synthesis and Antioxidant Activity of Substituted‐1,3,2‐diazaphosphole 1‐Oxides.
Authors: Naidu Kalla Reddi Mohan , Rao Pasupuleti Visweswara , Raju Chamarthi Naga , Srinivasulu Kambam 
Published: February 2012

AbstractThe title compounds (III), (V) and (VII) exhibit moderate antioxidant properties compared to vitamin C.
ChemInform Abstract: Sesquiterpene Lactones from Inula falconeri, a Plant Endemic to the Himalayas, as Potential Antiinflammatory Agents.
Authors: Jin Huizi , et al. et al. 
Published: February 2012

Abstract[isolation, structural elucidation, antiinflammatory evaluation and structure—activity relationships of ten new sesquiterpenoids [e.g. (I)—(VI)] and twenty six known sesquiterpene lactones].
ChemInform Abstract: Myrseguinosides A—E, Five New Glycosides from the Fruits of Myrsine seguinii.
Authors: Matsunami Katsuyoshi , Otsuka Hideaki , Takeda Yoshio 
Published: February 2012

AbstractFive new glycosides named myrseguinosides A—E (I)‐(IV) are isolated from the butanol‐soluble fraction of the dried fruits of Myrsine seguinii together with eight known compounds.
ChemInform Abstract: Halioxepine, a New Meroditerpene from an Indonesian Sponge Haliclona sp.
Authors: Trianto Agus , Hermawan Idam , de Voogd Nicole Joy , Tanaka Junichi 
Published: February 2012

AbstractThe new meroditerpene named halioxepine (I) shows moderate cytotoxicity against NBT‐T2 cells and also antioxidant activity.
ChemInform Abstract: Dyscusins A—C, Three New Steroids from the Leaves of Dysoxylum cumingianum.
Authors: Kurimoto Shin‐ichiro , Kashiwada Yoshiki , Morris‐Natschke Susan Lynne , Lee Kuo‐Hsiung , Takaishi Yoshihisa 
Published: February 2012

AbstractThree new steroids named dyscusins A (III), B (I), and C (II) are isolated from the leaves of Dysoxylum cumingianum together with two known steroids.
ChemInform Abstract: Enantioselective Cascade Sequence to Indoloquinolizidines and Its Application in the Synthesis of epi‐Geissochizol.
Authors: Wu Xiaoyu , Zhang Yao , Dai Xiaoyang , Fang Huihui , Chen Jie , Cao Weiguo , Zhao Gang 
Published: February 2012

AbstractMichael addition of the tethered indole (I) to unsaturated aldehydes followed by Pictet—Spengler reaction yields indolo[2,3‐a]quinolizidine intermediates which are reductively converted to products (III) or (V).
ChemInform Abstract: Synthesis of 10‐Hydroxycamptothecin: Evaluation of New Moderators for the Chemoselective Reduction of Camptothecin.
Authors: Sekhar N. M. , Anjaneyulu Yerramilli , Acharyulu Palle V. R. 
Published: February 2012

AbstractCamptothecin was isolated from south‐east Asian trees.
ChemInform Abstract: Halichonines A, B, and C, Novel Sesquiterpene Alkaloids from the Marine Sponge Halichondria okadai Kadota.
Authors: Suenaga Kiyotake , et al. et al. 
Published: February 2012

AbstractThe title compounds (I) and (II) show inhibitory activities against the growth of the mammalian cancer cell lines L1210 and PC13, and halichonine B (Ib) reveals to induce apoptosis in HL60 cells.
ChemInform Abstract: Synthesis and Antiviral Evaluation of the 2′‐C‐Methyl Branched Derivative of a Nucleoside Analogue Inhibitor of RNA Viral Infections, T‐1106.
Authors: Pierra Claire , Counor Clement , Storer Richard , Gosselin Gilles 
Published: February 2012

AbstractBoth the new title compound (IV) and its α‐anomer (V) exhibit neither significant antiviral activity nor cytotoxicity.
ChemInform Abstract: Exploiting the Lipoic Acid Structure in the Search for Novel Multitarget Ligands Against Alzheimer′s Disease.
Authors: Rosini Michela , Simoni Elena , Bartolini Manuela , Tarozzi Andrea , Matera Riccardo , Milelli Andrea , Hrelia Patrizia , Andrisano Vincenza , Bolognesi Maria Laura , Melchiorre Carlo 
Published: February 2012

AbstractThe multimodal effective compound (I) inhibits the anticholinesterase (AChE) activity in a submicromolar range and shows a significant reduction of AChE‐induced anti‐aggregating efficacy without a cytotoxicity in neuronal‐like cells SH‐SY5Y up to the highest concentration of 50 μM.
ChemInform Abstract: Novel Tricyclic Inhibitors of IKK2: Discovery and SAR Leading to the Identification of 2‐Methoxy‐N‐((6‐(1‐methyl‐4‐(methylamino)‐1,6‐dihydroimidazo [4,5‐d]pyrrolo[2,3‐b]pyridin‐7‐yl)pyridin‐2‐yl)methyl)acetamide (BMS‐066).
Authors: Watterson Scott H. , et al. et al. 
Published: February 2012

AbstractThe title compound (I) demonstrates high in vitro potency, acceptable pharmacokinetic and physicochemical properties.
ChemInform Abstract: Recent Progress in the Use of N‐Halo Compounds in Organic Synthesis
Authors: Veisi Hojat , Ghorbani‐Vaghei Ramin , Zolfigol Mohamad Ali 
Published: February 2012

AbstractReview: use of N‐halo compounds as halogenating agents, in protection/deprotection chemistry, as oxidizing agents, in rearrangements and functional group transformations, in the formation of heterocyclic compounds and as catalysts; 174 refs.