bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonlinear ion-acoustic waves with Landau damping in non-Maxwellian space plasmas
Authors: Mushtaq Hadia , Singh Kuldeep , Zaheer Sadia , Kourakis Ioannis 
Published: June 2024

AbstractThe dynamics of nonlinear ion-acoustic solitary waves in the presence of kinetic (Landau type) damping have been investigated in a collisionless, non-magnetized electron-ion plasma. A cold ion fluid model, coupled to a Vlasov-type kinetic equation for the electron dynamics, has been adopted as a starting point. The electron population was assumed to be in a kappa-distributed state, in account of the non-Maxwellian behavior of energetic (suprathermal) electrons often observed in Space. A multiscale perturbation technique has led to an evolution equation for the electrostatic potential, in the form of a modified Korteweg-de Vries (KdV) equation, incorporating a non-local term accounting for Landau damping (associated with the electron statistics). Exact analytical solutions have been obtained, representing solitary waves undergoing amplitude decay over time. The combined effect of Landau damping and non-Maxwellian electron statistics (via the kappa parameter) on the characteristics of IASWs has been examined. Numerical integration of the evolution equation has been undertaken, to elucidate the importance of kinetic Landau damping on a shock-shaped initial condition. The results of this investigation aim to improve our understanding of the dynamics of nonlinear electrostatic waves under the influence of Landau damping in various space plasma environments.
A comprehensive study of the novel 4D hyperchaotic system with self-exited multistability and application in the voice encryption
Authors: Benkouider Khaled , Sambas Aceng , Bonny Talal , Al Nassan Wafaa , Moghrabi Issam A. R. , Sulaiman Ibrahim Mohammed , Hassan Basim A. , Mamat Mustafa 
Published: June 2024

AbstractThis paper describes a novel 4-D hyperchaotic system with a high level of complexity. It can produce chaotic, hyperchaotic, periodic, and quasi-periodic behaviors by adjusting its parameters. The study showed that the new system experienced the famous dynamical property of multistability. It can exhibit different coexisting attractors for the same parameter values. Furthermore, by using Lyapunov exponents, bifurcation diagram, equilibrium points’ stability, dissipativity, and phase plots, the study was able to investigate the dynamical features of the proposed system. The mathematical model’s feasibility is proved by applying the corresponding electronic circuit using Multisim software. The study also reveals an interesting and special feature of the system’s offset boosting control. Therefore, the new 4D system is very desirable to use in Chaos-based applications due to its hyperchaotic behavior, multistability, offset boosting property, and easily implementable electronic circuit. Then, the study presents a voice encryption scheme that employs the characteristics of the proposed hyperchaotic system to encrypt a voice signal. The new encryption system is implemented on MATLAB (R2023) to simulate the research findings. Numerous tests are used to measure the efficiency of the developed encryption system against attacks, such as histogram analysis, percent residual deviation (PRD), signal-to-noise ratio (SNR), correlation coefficient (cc), key sensitivity, and NIST randomness test. The simulation findings show how effective our proposed encryption system is and how resilient it is to different cryptographic assaults.
Loss of the proteasomal deubiquitinase USP14 induces growth defects and a senescence phenotype in colorectal cancer cells
Authors: Gubat Johannes , Sjöstrand Linda , Selvaraju Karthik , Telli Kübra , D’Arcy Pádraig 
Published: June 2024

AbstractThe proteasome-associated deubiquitinase USP14 is a potential drug target. Using an inducible USP14 knockout system in colon cancer cells, we found that USP14 depletion impedes cellular proliferation, induces cell cycle arrest, and leads to a senescence-like phenotype. Transcriptomic analysis revealed altered gene expression related to cell division and cellular differentiation. USP14 knockout cells also exhibited changes in morphology, actin distribution, and expression of actin cytoskeletal components. Increased ubiquitin turnover was observed, offset by upregulation of polyubiquitin genes UBB and UBC. Pharmacological inhibition of USP14 with IU1 increased ubiquitin turnover but did not affect cellular growth or morphology. BioGRID data identified USP14 interactors linked to actin cytoskeleton remodeling, DNA damage repair, mRNA splicing, and translation. In conclusion, USP14 loss in colon cancer cells induces a transient quiescent cancer phenotype not replicated by pharmacologic inhibition of its deubiquitinating activity.
Computational approach to grain boundary segregation engineering of nickel-base superalloys
Authors: Uruchida Haruna , Tsukada Yuhki , Matsuoka Yusuke , Koyama Toshiyuki 
Published: June 2024

AbstractGrain boundary (GB) strengthening elements, such as B, C, and Zr have been added in small amounts to nickel-base superalloys. However, their strengthening effects have not been quantified and no specific design principles for GB chemistry have been reported. In this study, we propose a practical computational approach for the GB segregation engineering of nickel-base superalloys. Considering the partitioning of alloying elements into coexisting phases (strengthening phases, carbides, etc.), the equilibrium composition of a high-angle GB was computed for several nickel-base superalloys using a calculation of phase diagrams database. The computational results showed that B and Mo were enriched at the GB in most of the investigated alloys. The creep rupture strengths of the investigated alloys were predicted using the computed GB composition as a regression model feature. The regression coefficients for the features confirm that B segregation at the GB has a non-negligible strengthening effect on nickel-base superalloys.
CT-based muscle and adipose measurements predict prognosis in patients with digestive system malignancy
Authors: Zheng Kaiwen , Liu Xiangliang , Li Yuguang , Cui Jiuwei , Li Wei 
Published: June 2024

AbstractThe role of skeletal muscle and adipose tissue in the progression of cancer has been gradually discussed, but it needs further exploration. The objective of this study was to provide an in-depth analysis of skeletal muscle and fat in digestive malignancies and to construct novel predictors for clinical management. This is a retrospective study that includes data from Cancer Center, the First Hospital of Jilin University. Basic characteristic information was analyzed by T tests. Correlation matrices were drawn to explore the relationship between CT-related indicators and other indicators. Cox risk regression analyses were performed to analyze the association between the overall survivals (OS) and various types of indicators. A new indicator body composition score (BCS) was then created and a time-dependent receiver operating characteristic curve was plotted to analyze the efficacy of the BCS. Finally, a nomogram was produced to develop a scored-CT system based on BCS and other indicators. C-index and calibration curve analyses were performed to validate the predictive accuracy of the scored-CT system. A total of 575 participants were enrolled in the study. Cox risk regression model revealed that VFD, L3 SMI and VFA/SFA were associated with prognosis of cancer patients. After adjustment, BCS index based on CT was significantly associated with prognosis, both in all study population and in subgroup analysis according to tumor types (all study population: HR 2.036, P < 0.001; colorectal cancer: HR 2.693, P < 0.001; hepatocellular carcinoma: HR 4.863, P < 0.001; esophageal cancer: HR 4.431, P = 0.008; pancreatic cancer: HR 1.905, P = 0.016; biliary system malignancies: HR 23.829, P = 0.035). The scored-CT system was constructed according to tumor type, stage, KPS, PG-SGA and BCS index, and it was of great predictive validity. This study identified VFD, L3 SMI and VFA/SFA associated with digestive malignancies outcomes. BCS was created and the scored-CT system was established to predict the OS of cancer patients.
Satellite-derived sandy shoreline trends and interannual variability along the Atlantic coast of Europe
Authors: Castelle Bruno , Kras Etiënne , Masselink Gerd , Scott Tim , Konstantinou Aikaterini , Luijendijk Arjen 
Published: June 2024

AbstractMonitoring sandy shoreline evolution from years to decades is critical to understand the past and predict the future of our coasts. Optical satellite imagery can now infer such datasets globally, but sometimes with large uncertainties, poor spatial resolution, and thus debatable outcomes. Here we validate and analyse satellite-derived-shoreline positions (1984–2021) along the Atlantic coast of Europe using a moving-averaged approach based on coastline characteristics, indicating conservative uncertainties of long-term trends around 0.4 m/year and a potential bias towards accretion. We show that west-facing open coasts are more prone to long-term erosion, whereas relatively closed coasts favor accretion, although most of computed trends fall within the range of uncertainty. Interannual shoreline variability is influenced by regionally dominant atmospheric climate indices. Quasi-straight open coastlines typically show the strongest and more alongshore-uniform links, while embayed coastlines, especially those not exposed to the dominant wave climate, show weaker and more variable correlation with the indices. Our results provide a spatial continuum between previous local-scale studies, while emphasizing the necessity to further reduce satellite-derived shoreline trend uncertainties. They also call for applications based on a relevant averaging approach and the inclusion of coastal setting parameters to unravel the forcing-response spectrum of sandy shorelines globally.
Fluid-particle-structure interaction in single shot peening
Authors: Mizuno Yusuke , Misaka Takashi , Furukawa Yoshiyuki 
Published: June 2024

AbstractShot peening is a widely used cold-working process. Physical phenomena of shot peening are analyzed using the developed fluid-particle-structure coupled solver. The influences of the flow field and shot peening parameters such as the shot impact velocity and shot size are investigated in the case of the falling, impacting, and rebounding single particle. The weakly coupled solver applies the immersed boundary method which enables direct evaluation of the interactions between the unsteady flow field and moving/deforming objects. The elastoplastic object of AISI4340 during the collision of rigid steel shot is analyzed dynamically using the finite element method. Consequently, it is clarified that the flow field of the post-collision between the shot and structure can be characterized by the relative Reynolds number, which is based on the shot diameter and relative velocity between the uniform flow and rebounding shot velocities. As the relative Reynolds number increases, the complex flow field and vortex structures are generated at the collision location. These fluid structures affect the collision phenomena resulting in the random behavior of the shot and the asymmetric indentation in the structure.
ATF4 inhibits tumor development and mediates p-GCN2/ASNS upregulation in colon cancer
Authors: Chen Jiawei , Huang Xiaopeng , Zhang Shuai , Zhu Xiaodong 
Published: June 2024

AbstractColon cancer (CC) is a highly malignant tumor with a high incidence and poor prognosis. This study aimed to explore the function and molecular mechanisms of activating transcription factor 4 (ATF4) in CC. The expression levels of ATF4, GCN2, and ASNS in CC tissues were measured using immunohistochemistry (IHC) and reverse transcription quantitative PCR (RT-qPCR). Cell counting kit-8 (CCK-8), clone formation, transwell, and flow cytometry assays were conducted to assess cell viability, clonogenicity, migration, invasion, cell cycle, and apoptosis, respectively, in the ATF4 knockdown and overexpression SW480 cell lines. The effect of ATF4 on the expression of GCN2 and ASNS was detected using RT-qPCR, Chip-qPCR, and western blotting. ATF4, GCN2, and ASNS were expressed at low levels in CC tissues, and all had a significant negative correlation with tumor diameter. ATF4 knockdown promoted cell proliferation, invasion, and S-phase cell cycle and inhibited apoptosis in SW480 cells. In contrast, ATF4 overexpression had the opposite effect. Furthermore, ATF4 overexpression enhanced ATF4 binding to the ASNS promoter region. ATF4 knockdown significantly inhibited the expression of p-GCN2 and ASNS, whereas ATF4 overexpression significantly upregulated their expression. ATF4 inhibited CC cell viability, clone formation ability, migration, and invasion and promoted apoptosis, possibly by regulating the expression of p-GCN2 and ASNS. Our study provides a novel potential therapeutic target for the treatment of CC.
Implications of human–wildlife conflict on the diet of an endangered avian top predator in the northern Andes
Authors: Restrepo-Cardona Juan Sebastián , Kohn Sebastián , Renjifo Luis Miguel , Vásquez-Restrepo Juan D. , Zuluaga Santiago , Vargas Félix Hernán , Narváez Fabricio , Salagaje Luis A. , Recalde Abel , Gaitán-López Erik Camilo , Salazar Andy , Hull Vanessa 
Published: June 2024

AbstractConflicts between rural people and the Endangered Black-and-chestnut Eagle (Spizaetus isidori) are a prominent conservation concern in the northern Andes, as at least 60 eagles were poached between 2000 and 2022 in response to poultry predation. Here, we conducted direct observations to analyze the Black-and-chestnut Eagle diet and evaluated how forest cover affects the feeding habits of the species during nestling-rearing periods in 16 nests located in different human-transformed Andean landscapes of Ecuador and Colombia. We analyzed 853 prey items (46 species) delivered to nestlings. We used Generalized Linear Models to test whether the percent forest cover calculated within varying buffer distances around each nest and linear distances from the nest to the nearest settlement and pasture areas were predictors of diet diversity and biomass contribution of prey. Forest cover was not a factor that affected the consumption of poultry; however, the eagle regularly preyed on chickens (Gallus gallus) (i.e., domestic Galliformes) which were consumed by 15 of the 16 eagle pairs, with biomass contributions (14.57% ± 10.55) representing 0.6–37% of the total prey consumed. The Black-and-chestnut Eagle is an adaptable generalist able to switch from mammalian carnivores to guans (i.e., wild Galliformes) in human-dominated landscapes, and eagles nesting in sites with low forest cover had a less diverse diet than those in areas with more intact forests. Management actions for the conservation of this avian top predator require studies on the eagle’s diet in areas where human persecution is suspected or documented, but also maintaining forest cover for the wild prey of the species, development of socio-economic and psychological assessments on the drivers behind human-eagle conflicts, and the strengthening of technical capacities of rural communities, such as appropriate poultry management.
Nucleotide metabolism in cancer cells fuels a UDP-driven macrophage cross-talk, promoting immunosuppression and immunotherapy resistance
Authors: Scolaro Tommaso , Manco Marta , Pecqueux Mathieu , Amorim Ricardo , Trotta Rosa , Van Acker Heleen H. , Van Haele Matthias , Shirgaonkar Niranjan , Naulaerts Stefan , Daniluk Jan , Prenen Fran , Varamo Chiara , Ponti Donatella , Doglioni Ginevra , Ferreira Campos Ana Margarida , Fernandez Garcia Juan , Radenkovic Silvia , Rouhi Pegah , Beatovic Aleksandar , Wang Liwei , Wang Yu , Tzoumpa Amalia , Antoranz Asier , Sargsian Ara , Di Matteo Mario , Berardi Emanuele , Goveia Jermaine , Ghesquière Bart , Roskams Tania , Soenen Stefaan , Voets Thomas , Manshian Bella , Fendt Sarah-Maria , Carmeliet Peter , Garg Abhishek D. , DasGupta Ramanuj , Topal Baki , Mazzone Massimiliano 
Published: June 2024

AbstractMany individuals with cancer are resistant to immunotherapies. Here, we identify the gene encoding the pyrimidine salvage pathway enzyme cytidine deaminase (CDA) among the top upregulated metabolic genes in several immunotherapy-resistant tumors. We show that CDA in cancer cells contributes to the uridine diphosphate (UDP) pool. Extracellular UDP hijacks immunosuppressive tumor-associated macrophages (TAMs) through its receptor P2Y6. Pharmacologic or genetic inhibition of CDA in cancer cells (or P2Y6 in TAMs) disrupts TAM-mediated immunosuppression, promoting cytotoxic T cell entry and susceptibility to anti-programmed cell death protein 1 (anti-PD-1) treatment in resistant pancreatic ductal adenocarcinoma (PDAC) and melanoma models. Conversely, CDA overexpression in CDA-depleted PDACs or anti-PD-1-responsive colorectal tumors or systemic UDP administration (re)establishes resistance. In individuals with PDAC, high CDA levels in cancer cells correlate with increased TAMs, lower cytotoxic T cells and possibly anti-PD-1 resistance. In a pan-cancer single-cell atlas, CDAhigh cancer cells match with T cell cytotoxicity dysfunction and P2RY6high TAMs. Overall, we suggest CDA and P2Y6 as potential targets for cancer immunotherapy.
Macrophages upregulate mural cell-like markers and support healing of ischemic injury by adopting functions important for vascular support
Authors: Amoedo-Leite Catarina , Parv Kristel , Testini Chiara , Herrera-Hidalgo Carmen , Xu Feifei , Giraud Antoine , Malaquias Marta , Fasterius Erik , Holl Daniel , Seignez Cedric , Göritz Christian , Christoffersson Gustaf , Phillipson Mia 
Published: June 2024

AbstractSterile inflammation after injury is important for tissue restoration. In injured human and mouse tissues, macrophages were recently found to accumulate perivascularly. This study investigates if macrophages adopt a mural cell phenotype important for restoration after ischemic injury. Single-cell RNA sequencing of fate-mapped macrophages from ischemic mouse muscles demonstrates a macrophage-toward-mural cell switch of a subpopulation of macrophages with downregulated myeloid cell genes and upregulated mural cell genes, including PDGFRβ. This observation was further strengthened when including unspliced transcripts in the analysis. The macrophage switch was proven functionally relevant, as induction of macrophage-specific PDGFRβ deficiency prevented their perivascular macrophage phenotype, impaired vessel maturation and increased vessel leakiness, which ultimately reduced limb function. In conclusion, macrophages in adult ischemic tissue were demonstrated to undergo a cellular program to morphologically, transcriptomically and functionally resemble mural cells while weakening their macrophage identity. The macrophage-to-mural cell-like phenotypic switch is crucial for restoring tissue function and warrants further exploration as a potential target for immunotherapies to enhance healing.
Identifying and Addressing Functional Communication Challenges in Patients With Behavioral Variant Frontotemporal Dementia
Authors: Meade Gabriela , Machulda Mary M. , Clark Heather M. , Duffy Joseph R. , Botha Hugo , Whitwell Jennifer L. , Josephs Keith A. , Utianski Rene L. 
Published: June 2024

Purpose:
We describe the communication challenges of four patients with a neurodegenerative disorder consistent with behavioral variant frontotemporal dementia (bvFTD), characterized by early behavioral and personality changes. By describing their clinical profiles, we identify common barriers to functional communication in this population and provide recommendations for how speech-language pathologists (SLPs) might contribute to minimizing them.

Method:
Four patients with bvFTD were selected from a cohort of patients with progressive communication impairments. Three of them returned for at least one follow-up visit. Case histories are presented along with the results of comprehensive speech and language, neuropsychological, and neurological testing.

Results:
At the time of initial evaluation, patients were between the ages of 54 and 66 years and had been experiencing symptoms for 1.5–6 years. Consistent with their bvFTD diagnoses, all patients had prominent behavioral and personality changes that impacted communication. Patients 1 and 2 also had mild aphasia at enrollment, primarily characterized by anomia and loss of word meaning. Patients 3 and 4 both had apraxia of speech and moderate-to-severe aphasia at enrollment with prominent anomia and agrammatism. All four patients had impaired executive functioning and relative sparing of visuospatial skills; episodic memory was also impaired for Patients 2 and 4. Even though functional communication was progressively limited for all patients, none of them received regular support from an SLP.

Conclusions:
This case series adds to a scant, but growing, literature demonstrating that patients with bvFTD have communication impairments. SLPs are uniquely positioned to identify barriers to functional communication and to provide tailored strategy training to the patients and their care partners over the course of their disease. Systematic evaluation of the efficacy of treatment in this population would be valuable.

Supplemental Material:

https://doi.org/10.23641/asha.25933762
Investigating the effects of current thresholds on phase jump limits and withstand capabilities in grid‐forming converters
Authors: Zhang Ziqian , Schuerhuber Robert , Fickert Lothar , Chen Guochu 
Published: June 2024

AbstractThe inherent constraints of grid‐forming converters affect their ability to maintain voltage source characteristics within a specific operational range. In response to these limitations, ongoing pilot projects involving grid‐forming technology have adjusted their current thresholds up to three times the rated current, significantly exceeding the traditionally threshold of 1.2 times the rated current. This paper aims to investigate the effects of current thresholds on the dynamic responses of grid‐forming converters under large disturbances, with the intention of identifying an optimal current threshold that meets the grid's demands for maintaining voltage source characteristics and overall stability. A novel power angle relationship is introduced, integrating current limits and anti‐windup voltage controls into the equivalent circuit models of these converters. Analytical expressions for stable and unstable equilibrium points are derived, improving insights into the converters' dynamic behaviour and their resilience to phase jumps across various current thresholds and short‐circuit ratios. Findings indicate that higher current thresholds substantially improve phase jump limits and withstand capabilities. The paper concludes with proposed configurations and optimization strategies for current thresholds, all supported by experimental validation.