bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atomic force microscopy in the characterization and clinical evaluation of neurological disorders: current and emerging technologies
Authors: She David T. , Nai Mui Hoon , Lim Chwee Teck 
Published: June 2024

AbstractThis review examines the significant role of Atomic Force Microscopy (AFM) in neurobiological research and its emerging clinical applications in diagnosing neurological disorders and central nervous system (CNS) tumours. AFM, known for its nanometre-scale resolution and piconewton-scale force sensitivity, offers ground breaking insights into the biomechanical properties of brain cells and tissues and their interactions within their microenvironment. This review delves into the application of AFM in non-clinical settings, where it characterizes molecular, cellular, and tissue-level aspects of neurological disorders in experimental models. This includes studying ion channel distribution, neuron excitability in genetic disorders, and axonal resistance to mechanical injury. In the clinical context, this article emphasizes AFM’s potential in early detection and monitoring of neurodegenerative diseases, such as Alzheimer's Disease (AD), Parkinson's Disease (PD) and amyotrophic lateral sclerosis (ALS), through biomarker characterization in biofluids such as cerebrospinal fluid and blood. It also examines the use of AFM in enhancing the grading and treatment of CNS tumours by assessing their stiffness, providing a more detailed analysis than traditional histopathological methods. Despite its promise, this review acknowledges challenges in integrating AFM into clinical practice, such as sample heterogeneity and data analysis complexity, and discusses emerging solutions such as machine learning and neural networks to overcome these hurdles. These advancements, combined with commercial nanotechnology platforms, herald a new era in personalized treatment strategies for management, treatment and diagnosis of neurological disorders.
Graphical Abstract
Delineating petrological feature and geochemical characteristics of volcanic rocks from the Herson-Kilkis Area, Northern Greece
Authors: Kelepertsis Akindynos E. , Alexakis Dimitrios E. 
Published: June 2024

AbstractThe geochemical data of this study confirm a previous suggestion that the Herson—Kilkis rhyolites are the crystallization products of a magma generated by the partial fusion of K-rich schists or para-gneisses and erupted along a dip-slip fault at the western boundary of the Serbo—Macedonian massif. High-K rhyolites occur in the area around Kilkis town along the western boundary of the Serbo-Macedonian massif. The chemistry of the rocks is characterized by high K2O contents (7–12 Wt %), high K2O/Na2O ratios (2–22), low CaO (0.04–0.16%) and Sr (0–83 mg Kg−1) contents and high Rb/Sr ratios (4–40). The trace elements (in mg Kg−1), Nb (Not Detected–41), Nd (5–87), Ce (16–119), La (9–67), Rb (Not Detected–358) and Y (10–87) present higher contents than those of rhyolites derived from a more basic magma by low-pressure fractional crystallization.
Gujarat’s plastic plight: unveiling characterization, abundance, and pollution index of beachside plastic pollution
Authors: Yogi KetanKumar , Rabari Vasantkumar , Patel Krupal , Patel Heris , Trivedi Jigneshkumar , Rakib Md. Refat Jahan , Kumar Rakesh , Proshad Ram , Walker Tony R. 
Published: June 2024

AbstractPlastic pollution poses a pervasive threat to ecosystems worldwide, jeopardizing marine life, contaminating water sources, and perpetuating a global environmental crisis. Spatial and temporal distribution of beach debris was quantitatively assessed on three recreational beaches in Gujarat State, India. A total of six debris categories were recorded with a mean of 0.9 items/m2 in number and 3.62 g/m2 in weight. A total of Mean debris concentrations and weight per debris item did not vary significantly between study sites. Highest debris concentrations were observed in October 2021 at all sites. Around 90% was macro-debris (2.5–100 cm), with white and transparent colours most frequently encountered. Based on Clean Coast Index findings, all sites were categorized as "dirty". Plastic Abundance Index revealed that all sites had a very high abundance of plastics compared to other beach debris. Recreational activities on beaches, tourism, and extensive fishing can be the possible source of marine debris on Gujarat State. The findings of the current investigation is vital to understanding its pervasive environmental impact, encompassing threats to biodiversity, water quality, and ecosystems, while guiding effective policies to mitigate these repercussions on a global scale. It can be helpful to establish mitigation strategies urgently required to reduce marine debris pollution along the Gujarat Coast. It is recomanded to implement urgently needed mitigation strategies to diminish marine debris pollution along the Gujarat Coast.
Imaging findings in a rare case of alveolar, hepatic and splenic sarcoidosis presenting with thrombotic thrombocytopenic purpura
Authors: Vaccarino Federica , Parillo Marco , Perillo Gloria , Beomonte Zobel Bruno 
Published: June 2024

AbstractThrombotic thrombocytopenic purpura (TTP) is an acute haematological disorder characterized by severe ADAMTS13 enzyme deficiency, leading to consumptive thrombocytopenia, mechanical haemolysis, and organ damage. Its association with multisystemic sarcoidosis is extremely rare and, to the best of our knowledge, described in only two cases so far. We present the case of a 52-year-old woman with TTP and antibodies anti-ADAMTS13, showing computed tomography (CT) and magnetic resonance imaging (MRI) evidence of pulmonary, hepatic, and splenic lesions initially reported as ischemic/inflammatory changes. A follow-up MRI of the abdomen revealed increased evidence of the liver lesions, focal intrahepatic bile duct dilatation, splenic lesions, and enlarged hepatic hilar nodes. The follow-up chest CT showed increased evidence of the parenchymal lung consolidations. Given the radiological persistence of those alterations and the history of TTP, the hypothesis of an IgG4-related disease was then made. The IgG4 levels were found to be normal, while the histological examination of the liver revealed non-necrotizing granulomatous chronic inflammation. Elevated levels of angiotensin-converting enzyme were found, and the QuantiFERON-TB Gold test was negative for tuberculosis infection. Thus, the overall clinical picture was consistent with multisystemic sarcoidosis (alveolar, hepatic, and splenic). The diagnosis of sarcoidosis, already challenging due to the variability of its clinical presentation, can become even more complicated when it manifests with uncommon haematological manifestations such as TTP, along with non-specific extra-pulmonary involvement. While imaging aids in documenting organ damage, the definitive diagnosis of sarcoidosis necessitates histologic confirmation of noncaseating granulomas and the exclusion of other possible granulomatous diseases.
Quality of Life Factors and Measurement in Adult Meningioma Patients: A Systematic Review
Authors: Jonas Kara , Fazari Melissa , Cusimano Michael D. , Ahn Matthew 
Published: June 2024

ABSTRACT:Background:Meningiomas are common brain neoplasms that can significantly influence health-related quality of life (HRQOL), yet the factors influencing HRQOL in adult patients remain unclear. We aimed to bridge this knowledge gap by determining these key factors.Methods:We conducted a systematic review, searching EMBASE, MEDLINE, CINAHL, Scopus and PsycINFO up to February 2024. We included original, peer-reviewed studies focusing on adult patients (>18 years) with current or past meningioma at any stage of treatment that measured HRQOL or its proxies in relation to patient-, tumour- and treatment-related factors. Two independent reviewers screened abstracts and full-texts, selecting studies with an acceptable risk of bias for data extraction and narrative synthesis. The protocol of this review was registered on PROSPERO (# CRD42023431097).Results:Of N = 3002 studies identified, N = 31 studies were included. Key factors found to influence HRQOL in adult meningioma patients include surgery, radiotherapy, neurological function, functional status, comorbidities, sleep quality, psychological impairment, age and employment. Factors related to tumour characteristics yielded inconsistent findings. Heterogeneity and inconsistencies in HRQOL measurement across studies hindered definitive conclusions about the impact of factors on HRQOL.Conclusion:Our review elucidates the multifaceted influences on HRQOL in meningioma patients, with significant variability due to patient-, tumour- and treatment-related factors. We emphasize the need for standardized, disease-specific HRQOL assessments in meningioma patients. Collaborative efforts towards consistent, large-scale, prospective research are essential to comprehensively understand and improve HRQOL, thereby enhancing tailored care for this population.
Political Dynasties in Canada
Authors: Rivard Alex B. , Godbout Jean-François , Bodet Marc André 
Published: June 2024

Abstract
Using a unique dataset of legislators' electoral and biographical data in the Canadian provinces of Ontario, Quebec, New Brunswick, Nova Scotia and the federal parliament, this article analyses the extent to which family dynasties affected the career development of legislators since the mid-18th century. We find that the prevalence of dynasties was higher in provincial legislatures than it was in the federal parliament, that the number of dynasties in the Senate increased until the mid-20th century, and that the proportion of dynastic legislators at the subnational level was similar to the numbers seen in the United Kingdom during the early 19th century. Our results confirm the existence of a clear career benefit in terms of cabinet and senate appointments. In contrast to the American case and in line with the United Kingdom experience, we find no causal relationship between a legislator's tenure length and the presence of a dynasty.
The Communal Roots of Mexico’s Maquila Industry: Urbanization, Land, and Inequality in Ciudad Juárez, 1960–2000
Authors: Carrillo Mateo J. , Pérez Jonatan 
Published: June 2024

Abstract
This article analyzes the urbanization and privatization of communal lands (ejidos) in Ciudad Juárez, Mexico, via a computer vision model that utilizes Google Street View (GSV) and Geographic Information System (GIS) imagery. Our innovative methodology reveals how processes of ejidal urbanization in Mexico’s northern borderlands contributed to the rise of multinational factories (maquiladoras) and geographies of inequality and violence. Past scholarship on the (d)evolution of ejidal land tenure details how periurban ejidal lands throughout Mexico were often sites of impoverishment and a lack of investment, featuring informal settlement and rapid or chaotic urbanization following the country’s 1960 urban turn. Through its use of novel sources and methods, this article demonstrates that the urbanization process in Juárez’s principal periurban ejidos diverged from this classic model in specific ways. By combining conventional historical sources with visual data like GSV and GIS imagery, Juárez’s former and current ejidal landscapes reveal high levels of investment, formal planning, and infrastructure. We argue that Juárez’s distinctive physical, political, and economic geographies shaped the overwhelmingly industrial, private, and invested character of the city’s (former and current) periurban ejidal lands. This process occurred via a globalized modernization regime that forged disparate landscapes of investment and inequality beginning in the 1950s.
Recognizing “camera cues”: policing, cellphones and citizen countersurveillance
Authors: Alston Brandon 
Published: June 2024

AbstractOver the past decade, recording technologies have enabled organized activists and ordinary residents to capture and circulate videos of police misconduct. Existing research focuses primarily, however, on organized activists who rely on formal training programs to record police behaviors. If formal programs train organized activists to capture police abuses on camera, how then do ordinary residents determine when they should record police behavior? Drawing on in-depth interviews with Black men who live in a Southside Chicago neighborhood, this study finds that residents’ recurrent interactions with police enable them to interpret officers’ words and actions as symbols of police misconduct, which, in subsequent exchanges, serve as signals to record events with their cellphones – what I term “camera cues.” Camera cues facilitate situated conceptions of legal authority that trigger residents’ distrust of police, reflecting the micro-dynamic connections between individuals’ legal consciousness and legal cynicism. Equipped with cellphones, residents scrutinize officers’ outward displays and police–citizen interactions to challenge police misconduct. While recording police behavior makes it possible at least occasionally to resist the dominance of legal authority, doing so often involves additional risks, including the destruction of their cellphones, verbal and physical threats, and arrests.
Hierarchical hub-filament structures and gas inflows on galaxy-cloud scales
Authors: Zhou Jian-Wen , Davis Timothy 
Published: June 2024

Abstract
We investigated the kinematics and dynamics of gas structures on galaxy-cloud scales in two spiral galaxies NGC5236 (M83) and NGC4321 (M100) using CO (2

$-$

1) line. We utilised the FILFINDER algorithm on integrated intensity maps for the identification of filaments in two galaxies. Clear fluctuations in velocity and density were observed along these filaments, enabling the fitting of velocity gradients around intensity peaks. The variations in velocity gradient across different scales suggest a gradual and consistent increase in velocity gradient from large to small scales, indicative of gravitational collapse, something also revealed by the correlation between velocity dispersion and column density of gas structures. Gas structures at different scales in the galaxy may be organised into hierarchical systems through gravitational coupling. All the features of gas kinematics on galaxy-cloud scale are very similar to that on cloud-clump and clump-core scales studied in previous works. Thus, the interstellar medium from galaxy to dense core scales presents multi-scale/hierarchical hub-filament structures. Like dense core as the hub in clump, clump as the hub in molecular cloud, now we verify that cloud or cloud complex can be the hub in spiral galaxies. Although the scaling relations and the measured velocity gradients support the gravitational collapse of gas structures on galaxy-cloud scales, the collapse is much slower than a pure free-fall gravitational collapse.
Orbital period variation analysis of the HS 0705+6700 post-common envelope binary
Authors: Er Huseyin , Özdönmez Aykut , Nasiroglu Ilham , Kenger Muhammet Emir 
Published: June 2024

Abstract
To detect additional bodies in binary systems, we performed a potent approach of orbital period variation analysis. In this work, we present 90 new mid-eclipse times of a short-period eclipsing binary system. Observations were made using two telescopes from 2014 to 2024, extending the time span of the

$O-C$

diagram to 24 yr. The data obtained in the last seven years indicate significant deviations in the

$O-C$

diagram from the models obtained in previous studies. We investigated whether this variation could be explained by mechanisms such as the LTT effect or Applegate. To investigate the cyclic behaviour observed in the system with the light travel time effect, we modelled the updated

$O-C$

diagram using different models including linear/quadratic terms and additional bodies. The updated

$O-C$

diagram is statistically consistent with the most plausible solutions of models that include multiple brown dwarfs close to each other. However, it has been found that the orbit of the system is unstable on short time scales. Using three different theoretical definitions, we have found that the Applegate mechanism cannot explain the variation in the orbital period except for the model containing the fifth body. Therefore, due to the complex nature of the system, further mid-eclipse time is required before any conclusions can be drawn about the existence of additional bodies.
Consumption of soya isoflavones improved polycystic ovary syndrome-associated metabolic disorders in a rat model
Authors: Xiao Chao-Wu , Carbonel Adriana A. , Lima Patricia D. A. , Hendry Amy , Tsang Benjamin K. 
Published: June 2024

AbstractPolycystic ovary syndrome is associated with increased risks for certain metabolic disorders such as insulin resistance, non-alcoholic fatty liver disease and suppressed ovarian follicular development. This study aimed to examine whether soya isoflavones (ISF) mitigate these polycystic ovary syndrome-associated metabolic disorders in a rat model. Weanling Sprague-Dawley female rats were randomly divided into six groups and were treated with either 0 or 83 µg/d dihydrotestosterone (DHT) to induce polycystic ovary syndrome and fed diets containing 0, 0·5, or 1 g ISF/kg diet for 8 weeks. DHT treatment increased food intake, body weight gain (P < 0·001), percentage of primordial follicles (60 % v. 50·9 %, P < 0·05) and accumulation of lipid droplets in the livers. It also elevated serum total cholesterol, free cholesterol, TAG, NEFA and leptin and hepatic total cholesterol and NEFA. Additionally, DHT treatment reduced the percentage of primary follicles (13·8 % v. 30·2 %, P < 0·05), ovary weight and length (P < 0·001), as well as insulin sensitivity (P < 0·01) compared with the Control. ISF intake at 1 g/kg reduced body weight gain, serum total cholesterol, free cholesterol, NEFA, leptin and hepatic TAG and DHT-induced insulin resistance (P < 0·01). ISF intake at both levels decreased DHT-induced lipid droplet accumulation in the livers and changes in the percentages of primordial and primary follicles. Dietary soya ISF alleviated DHT-induced body weight gain, insulin resistance and hepatic lipid droplet accumulation, as well as suppressed ovarian follicular development. This suggests that the consumption of soya foods or ISF supplements may be beneficial for individuals with polycystic ovary syndrome, mitigating the associated metabolic disorders such as diabetes and non-alcoholic fatty liver disease.
The indirect influence of potential mates on survival and reproduction of Tyrophagus curvipenis (Acari: Acaridae)
Authors: Li Guang-Yun , Lam Wendy , Zhang Zhi-Qiang 
Published: June 2024

AbstractThe social-sexual environment is well known for its influence on the survival of organisms by modulating their reproductive output. However, whether it affects survival indirectly through a variety of cues without physical contact and its influence relative to direct interaction remain largely unknown. In this study, we investigated both the indirect and direct influences of the social-sexual environment on the survival and reproduction of the mite Tyrophagus curvipenis (Acari: Acaridae). The results demonstrated no apparent influence of conspecific cues on the survival of mites, but the survival and reproduction of mated female mites significantly changed, with the females mated with males having a significantly shortened lifespan and increased lifetime fecundity. For males, no significant difference was observed across treatments in their survival and lifespan. These findings indicate that direct interaction with the opposite sex has a much more profound influence on mites than indirect interaction and highlight the urgent need to expand research on how conspecific cues modulate the performance of organisms with more species to clarify their impacts across taxa.
Τhe Meaning of ἀλληγορέω in Galatians 4.24 Revisited
Authors: Ford J. Jarrett 
Published: June 2024

AbstractThe meaning of the verb ἀλληγορέω stands at the heart of the debate concerning Paul's hermeneutic in Galatians 4.21–31. If by using the term Paul means ‘I am interpreting these things allegorically’, then the question of Paul's interpretive procedure would be all but answered – he would likely be allegorising as the Greeks did before him and the early church fathers did after. However, if he does not mean this, then the question remains open. This article argues that the phrase ἅτινά ἐστιν ἀλληγορούμɛνα means ‘these things are symbolic’, which would indeed leave this question open. This rendering is best for two reasons: First, the majority of the uses of ἀλληγορέω available in the two hundred or so years surrounding the writing of Galatians mean ‘to speak symbolically’. Second, the contextual clues surrounding Paul's use of the term in Galatians itself, such as his call to hear the law in verse 21, strongly suggest such a reading. To prove this thesis, this article provides detailed exposition of the texts in which ἀλληγορέω occurred around the time Paul wrote Galatians before turning to Paul's own use of the term in Galatians 4.24.
Christianos in CIL iv, 679: The Possibility of an Image
Authors: Cook John Granger 
Published: June 2024

AbstractThere are good warrants for believing that either the word Christianos or the word Christiani, a reference to the Christians, was probably in a graffito on the wall of the atrium of the house now identified as vii.11.11 in Pompeii when Giuseppe Fiorelli excavated it in 1862. Karl Zangemeister edited it in 1871 as CIL iv, 679 and included two divergent transcriptions. In 1995, Paul Berry published a book in which he claimed that he had made an image of the word Christianos using an industrial microscope and high-intensity light. A research project to investigate that claim could be potentially useful for verifying or falsifying Berry's results.
Risk of central line-associated bloodstream infections during COVID-19 pandemic in intensive care patients in a tertiary care centre in Saudi Arabia
Authors: Alshamrani Majid M. , El-Saed Aiman , Aldayhani Omar , Alhassan Abdulaziz , Alhamoudi Abdullah , Alsultan Mohammed , Alrasheed Mohammed , Othman Fatmah 
Published: June 2024

Abstract
This retrospective study compared central line-associated bloodstream infection (CLABSI) rates per 1 000 central line days, and overall mortality before and during the COVID-19 pandemic in adult, paediatric, and neonatal ICU patients at King Abdul-Aziz Medical City-Riyadh who had a central line and were diagnosed with CLABSI according to the National Healthcare Safety Network standard definition. The study spanned between January 2018 and December 2019 (pre-pandemic), and January 2020 and December 2021 (pandemic). SARS-CoV-2 was confirmed by positive RT-PCR testing. The study included 156 CLABSI events and 46 406 central line days; 52 and 22 447 (respectively) in pre-pandemic, and 104 and 23 959 (respectively) during the pandemic. CLABSI rates increased by 2.02 per 1 000 central line days during the pandemic period (from 2.32 to 4.34, p < 0.001). Likewise, overall mortality rates increased by 0.86 per 1 000 patient days (from 0.93 to 1.79, p = 0.003). Both CLABSI rates (6.18 vs. 3.7, p = 0.006) and overall mortality (2.72 vs. 1.47, p = 0.014) were higher among COVID-19 patients compared to non-COVID-19 patients. The pandemic was associated with a substantial increase in CLABSI-associated morbidity and mortality.