bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mitigating Torque and Drag Challenges in Extended-Reach Drilling through Well Engineering Solutions
Authors: Sipi A. , Hamdi Z. , Aman M. , Bataee M. , Hassan A.M. 
Published: April 2024

Abstract
Torque and drag (T&D) are major mechanical considerations that dictate the success of extended-reach drilling (ERD) operations. As drilling technology continues to push the limits of horizontal reach, understanding and managing T&D becomes increasingly critical to well delivery. This study presents an integrated approach to T&D optimization through well modeling and engineering solutions, demonstrated through three ERD case studies offshore Peninsular Malaysia.
For each case study well, the design objectives, inherent T&D challenges posed by the extended well geometry, and drilling parameters were assessed. T&D modeling was conducted to simulate downhole conditions and identify potential mechanical limitations. Well A targeted a highly deviated open-hole section exceeding 3,200m measured depth with constrained surface equipment. Modeling showed that backreaming torque could exceed drill pipe ratings. Well B required cementing long open-hole intervals while maintaining low side forces to prevent casing wear. Simulated rotating and backreaming torques exceeded rig limits. Well C involved a tangent sidetrack and encountered high stress loads on the drill pipe.
To address the challenges, integrated well engineering solutions were evaluated for each well. For Well A, drill string torque reducers were incorporated to dampen stick-slip and reduce friction-induced torque. In Well B, utilizing a pseudo-catenary build mechanism optimized the well path gradients to lower side forces. Finally, Well C employed a tapered drill string design to satisfy stress criteria. Post-drill comparisons between modeled and actual downhole data validated the effectiveness of the implemented solutions in optimizing T&D.
The findings provide lessons on integrated well modeling and customized engineering solutions for efficient ERD project delivery. Through rigorous upfront planning and identification of well-specific challenges, appropriate solutions can be designed to safely expand drilling operational envelopes while controlling costs. Future work aims to broaden solution applications and further optimize integrated well construction management.
Surfactant Retention Analysis for CEOR Flooding at the Mature Oilfield
Authors: Adakhovskiy D. S. , Koryakin F. A. , Sidorovskaya E. A. , Turnaeva E. A. , Milchakov S. V. , Tretyakov N. Y. , Koltsov I. N. 
Published: April 2024

Enhanced oil recovery at the mature oilfields can be achieved by chemical flooding with use of surfactants on surfactant-polymer (SP) or alkali-surfactant-polymer technology [1], [2].
A surfactant as part of a flooding composition allows you to change the wettability of the rock, reduce interfacial tension, increase the capillary number, and form an oil emulsion which provides a significant increase in the efficiency of oil displacement [3]. The polymer included in the oil-displacing composition increases its viscosity and allows the displacement front aligning by improving the ratio of the mobilities of the oil and water phases [4], [5].
The design of chemical flooding is carried out considering the geological and physical characteristics of the formation and the composition of formation fluids. When choosing an oil-displacing composition for a specific field, it is important to reliably assess the effectiveness of chemical flooding and predict a possible increase in oil recovery. This paper evaluates the effectiveness of SP flooding options by combining comprehensive laboratory studies and hydrodynamic modeling based on them.
The prevalence and moderating factors of sleep disturbances in people living with HIV: A systematic review and meta-analysis
Authors: Lee Suonaa , Oh Jae Won , Park Kyung Mee , Ahn Jin Young , Lee San , Lee Eun 
Published: April 2024

Abstract

This systematic review and meta-analysis aimed to investigate the prevalence of self-reported sleep disturbances in people living with HIV considering the effects of age, depression, anxiety, CD4 cell counts, time since HIV diagnosis, study region, and the instruments used to measure sleep disturbances. We searched PubMed, PsycINFO, and EMBASE to include eligible articles. In this meta-analysis of 43 studies, the pooled prevalence of self-reported sleep disturbances was 52.29% (95% confidence interval = 47.69–56.87). The subgroup analyses revealed that variations in the sleep measurements and study region significantly contributed to the observed heterogeneity. In the meta-regression analyses, higher proportions of participants with depression or anxiety and longer times since HIV diagnosis were significantly associated with a higher prevalence of self-reported sleep disturbances after adjusting for mean age. Our findings emphasise the substantial burden of sleep disturbances in people living with HIV and identified comorbid depression and anxiety and the time since HIV diagnosis as significant moderators. These results underscore the importance of considering these factors when designing tailored screening programmes for high-risk patients and implementing early interventions to prevent and mitigate sleep disturbances in people living with HIV.
Plasmodium falciparum infections and Soil Transmitted helminthes correlates with Anemia in Pregnancy: Cross-Sectional Study in Kwale County, Kenya
Authors: Nyamu Gibson Waweru , Kaplich Raphael Tuitoek , Odhiambo Frendrick , King'oo Jacintah Mueni , Nyarambe Ronald Wigina 
Published: April 2024

Abstract

Background
Prevalence of Anemia in Pregnancy (AiP) in Kenya ranges from 40.6–69.1%. We estimated the prevalence of AiP and correlated Plasmodium falciparum infections and Soil transmitted Helminthes (STHs) infections among the predictors AiP among pregnant women attending antenatal care (ANC) visits.
Methods
We performed a cross-sectional study among pregnant women attending ANC at Msambweni Hospital, between January and March 2024. Data was collected and analyzed in Epi Info 7. Descriptive statistics were calculated and we compared pregnant women with AiP with those without the condition. Crude Odds Ratios (COR) and 95% confidence intervals (CI) were calculated to identify factors associated with AiP.
Results
A total of 396 pregnant women were included in the study. The mean age was 27.4 years ± 6.5 years. Proportion of anemia was reported in 201 (50.76%) participants, and the mean Hb was 10.87 mg/dl (± 1.46 mg/dl); 108 (53.73%). The malaria positivity rate among them was 13.38% (53/396), and for STHs was 24/396 (6.06%) (95% CI; 4.11–8.86). Pregnant women with Plasmodium falciparum infections were 2.5 times more likely to experience anemia compared to those without malaria parasites (COR; 2.5, 95% CI: 1.35–4.71). Pregnant women residing in rural areas were 4.1 times more likely to have anemia than those living in urban areas (COR; 4.1, 95% CI: 2.64–6.39). Furthermore, pregnant women with STH infections were 1.7 times more likely to experience anemia compared to those without STH infections (COR; 1.7, 95% CI: 0.71–3.90).
Conclusion
The prevalence of anemia among pregnant women attending Msambweni County Referral Hospital remains high, associated with Plasmodium falciparum infections, STH infections, and women residing rural areas. Tailored interventions measures should be put in place to reverse the trend.
Research on an Adaptive Machine Tool System for Three-Axis Vertical Electrochemical Machining Based on CPS
Authors: ZHANG Yujie , FANG Yadong , ZHANG Chuanyun 
Published: April 2024

Abstract
Traditional electrochemical machining systems rely on sensors and control systems to achieve automated control. However, the process still requires human supervision, and the system cannot adapt to changes based on on-site conditions. This article proposes and designs a digital electrochemical machining system based on CPS theory. The system utilizes a combination of simulation models and control systems to achieve simulation before, adaptive control during machining, and data tracing after machining. Compared to traditional control methods, this system can better control the machining current's stability, improving machining quality and efficiency. Finally, this article conducted relevant experiments, and the experimental results showed that the expected goals were met.
The presence of a robot in a close relationship reduces the hormonal changes associated with pain in a laboratory setting
Authors: Nakae Aya , Chang Wei-Chuan , Kishimoto Chie , Bu-Omer Hani M. , Onishi Yuya , Sumioka Hidenobu , Shiomi Masahiro 
Published: April 2024

Abstract

Human resources for healthcare management gradually fail to meet the demands because of an aging population. Pain is one of the most unpleasant sensations, and chronic pain is particularly difficult to manage. Loneliness is one of the key factors that worsens pain symptoms. Communication robots are used for smooth human communication. This study aimed to investigate whether communication robots would alter human pain perception via hormonal changes. Nineteen healthy participants experienced experimental pain before and after communicating with a robot named Moffly. Blood samples were collected to assess the hormonal levels. Pain was evaluated using the Short-form McGill Pain Questionnaire and Visual Analogue Scale. Furthermore, the participants’ mood and mental status were assessed by several questionnaires, including the Profile of Mood States 2nd Edition, Hospital Anxiety and Depression Scale, and Self-Rating Depression Scale. Subjective pain evaluation by the Visual Analogue Scale and the Short-form McGill Pain Questionnaire showed a significant decrease in pain in the robotic-communication condition than that in the control condition, accompanied by changes in the patterns of growth hormone, oxytocin, and estrogen. Depression and anxiety scores questionnaires also showed significant improvement after the experiment compared to before starting the experiment. The communication robots altered the participants’ pain perception, accompanied by changes in the growth hormone, oxytocin, dehydroepiandrosterone-sulfate, estrogen, and cortisol. Depression and anxiety improved after the intervention. This finding may reflect that not only humans but also robots can relieve human pain by suppressing factors that would exert a negative effect on pain perception, such as loneliness. Robots may be able to take over human functions, especially in the area of time-consuming cognitive behavioral therapy.
Esophageal Ganglioneuromatosis; A rare cause of intractable esophageal stenosis: A Case report
Authors: Zain Mostafa , Abdelmalak Mohamed , Waheeb Saber , Mansy Mohamed , Ibrahim Amir , Sabaa Bassma El 
Published: April 2024

Abstract

Background Ganglioneuromatosis is a rare type of benign neurogenic tumor that usually affects the sites of the major sympathetic ganglia in the retroperitoneum and the posterior mediastinum. Affection of the gastrointestinal tract is rare, and involvement of the esophagus is exceptional. To the best of our knowledge, only 4 cases of esophageal ganglioneuromatosis in adults were reported in the literature. No cases have been reported in the pediatric age group.Case presentation: An 11-year-old boy presented with dysphagia due to severe esophageal stenosis caused by esophageal ganglioneuromatosis.Conclusions: Despite its rarity, the present case implies that ganglioneuromatosis should be considered in children with idiopathic esophageal stenosis.
Spatiotemporal Patterns and Convergence Analysis of Green Agricultural Development: A Case Study of Xinjiang in China
Authors: Xia Wenhao , Ma Yiguang , Gao Yajing , Huo Yu 
Published: April 2024

Abstract
Under the dual historical responsibility of the double carbon target and the rural revitalisation strategy, effectively improving green agricultural development level in Xinjiang is an important means to break the dilemma of inclusive agricultural economic growth under the complex environmental regulations in the western region nowadays. Based on the panel data of Xinjiang from 2007 to 2019, this paper incorporates agricultural carbon emissions and agricultural non-point source pollution into the same framework. The SBM-Global-Malmquist-Luenberger(GML) productivity index including directional distance function is used to measure the agricultural green total factor productivity(AGTFP) in various regions of Xinjiang, and then the Dagum Gini coefficient decomposition and kernel density estimation are used to investigate the regional differences and dynamic evolution of agricultural green development level in Xinjiang. Finally, the classical and spatial β-convergence models are used to analyze the convergence characteristics and influencing factors of agricultural green development level in Xinjiang. The study found that: AGTFP in Xinjiang showed a "wave-like" development during the sample period, with an overall growth trend; There are significant non-equilibrium characteristics of AGTFP in the sample period, and the agglomeration phenomenon of AGTFP gradually strengthens over time; The overall variation in AGTFP shows a fluctuating upward trend, with intra-regional variation being greater in northern than in southern and eastern Xinjiang, and inter-regional variation making the highest contribution to the overall variation; Inter-regional differences AGTFP have gradually widened and are multi-polar. Polarisation has increased in the northern and southern Xinjiang regions, and the gap has decreased in the eastern Xinjiang region; There is significant absolute β convergence and conditional β convergence of AGTFP during the sample period, and the rate of conditional β convergence is significantly higher than that of absolute β convergence, and the inclusion of spatial factors further increases the rate of convergence. There is still much room for improvement in the level of green agricultural development in Xinjiang. We should speed up green agricultural technology innovation and improve AGTFP; formulate green agricultural development policies according to local conditions; pay attention to the convergence effect and promote coordinated growth in AGTFP in regional agriculture.
Modeling of Genetic Algorithm Tuned Adaptive Fuzzy Fractional Order PID Speed Control of PMSM for Electric Vehicle
Authors: sime Tolcha Lemma , Aluvada Prashant , Habtamu Solomon , Tolosa Zewde 
Published: April 2024

Abstract
This study presents a novel approach to enhance the speed control performance of Permanent Magnet Synchronous Motor (PMSM) drives in Electric Vehicles (EVs) through the implementation of a Genetic Algorithm (GA)-optimized Adaptive Fuzzy Fractional Order Proportional Integral Derivative (GA-AFFOPID) controller. PMSM technology, known for its efficiency, compactness, reliability, and versatility in motion control applications, is increasingly adopted in EV drive systems. However, the inherent non-linearity, dynamics, and uncertainties of PMSMs pose significant control challenges. The proposed GA-AFFOPID controller, tuned using a genetic algorithm, exhibits superior system dynamics, precise speed tracking, and robustness against parameter variations and sudden load disturbances. Comparative analysis with traditional control methods demonstrates the exceptional performance of the GA-AFFOPID controller, achieving a 1.796% lower overshoot, 0.97% faster rise time, 4.25% lower steady-state error, and 0.35% faster settling time compared to the adaptive fuzzy fractional order PID controller. These results highlight the significant performance improvements facilitated by the genetic algorithm optimization technique in enhancing the control performance of the adaptive fuzzy fractional order PID controller in PMSM drives for electric vehicle applications, paving the way for improved energy efficiency and overall performance of electric vehicle propulsion systems.
Surgical outcomes of robotic-assisted percutaneous fixation for thoracolumbar fractures in patients with ankylosing spondylitis
Authors: Ye Zhi-Yuan , Bai Jin-Yu , Ye Zhi-Min , Zhao Xu-Shen , Song Fang-Long , Zhou Zhen-Tao , Shan Bing-Chen , Zhou Xiao-Zhong 
Published: April 2024

Abstract

Background: Spinal fractures in patients with ankylosing spondylitis (AS) mainly present as instability, involving all three columns of the spine, and surgical intervention is often considered necessary. However, in AS patients, the significant alterations in bony structure and anatomy result in a lack of identifiable landmarks, which increases the difficulty of pedicle screw implantation. Therefore, we present the clinical outcomes of robotic-assisted percutaneous fixation for thoracolumbar fractures in patients with AS.
Methods: A retrospective review was conducted on a series of 12 patients diagnosed with AS. All patients sustained thoracolumbar fractures between October 2018 and October 2022 and underwent posterior robotic-assisted percutaneous fixation procedures. Outcomes of interest included operative time, intra-operative blood loss, complications, duration of hospital stay and fracture union. The clinical outcomes were assessed using the Visual Analogue Scale (VAS) and Oswestry Disability Index (ODI). To investigate the achieved operative correction, pre- and postoperative radiographs in the lateral plane were analyzed by measuring the Cobb angle.
Results: The 12 patients had a mean age of 62.8±13.0 years and a mean follow-up duration of 32.7±18.9 months. Mean hospital stay duration was 15±8.0 days. The mean operative time was 119.6±32.2 min, and the median blood loss was 50 (50, 250) ml. The VAS value improved from 6.8±0.9 preoperatively to 1.3±1.0 at the final follow-up (P<0.05). The ODI value improved from 83.6±6.1% preoperatively to 11.8±6.6% at the latest follow-up (P<0.05). The average Cobb angle changed from 15.2±11.0 pre-operatively to 8.3±7.1 at final follow-up (P<0.05). Bone healing was consistently achieved. Of the 108 screws implanted, 2 (1.9%) were improperly positioned. One patient experienced delayed nerve injury after the operation, but the nerve function returned to normal upon discharge.
Conclusion: Posterior robotic-assisted percutaneous internal fixation can be used as an ideal surgical treatment for thoracolumbar fractures in AS patients. However, while robot-assisted pedicle screw placement can enhance the accuracy of pedicle screw insertion, it should not be relied upon solely.
Emerging threat of Partial Artemisinin Resistance Markers in P. falciparum Parasite Populations in multiple geographical locations in high Transmission Regions of Uganda
Authors: Agaba Bosco B. , Travis Jye , Smith David , Rugera Simon P. , Zalwango Maria G. , Katureebe Charles , Mpirirwe Ruth , Bakary Dembo , Antonio Martin , Khalid Beshir , Ngozi Joseph , Kamya Moses R. , Kaleebu Pontiano , Piot Peter , Cheng Qin 
Published: April 2024

Abstract

Background: Artemisinin-based combination therapies (ACTs) is the only recommended treatment option for uncomplicated malaria, however the emergency and spread of partial artemisinin resistance threatens their effectiveness for malaria treatment in sub-Saharan Africa where the burden of malaria is highest. Early detection and reporting of validated P. falciparum Kelch 13 (PfK13) mutation markers is useful for tracking the emergence and spread of artemisinin resistance to inform containment.
Methods: Genomic surveillance was conducted at 50 sites across four regions of Uganda in Karamoja, Lango, Acholi and West Nile from June 2021 to August 2023 for assessing prevalence of pfhrp2/3 deletions and pfk13 mutations. Symptomatic malaria suspected patients were recruited and screened for presence of parasites. Out of 563 available dried blood spots (DBS), a random subset of 240 P. falciparum mono-infections, confirmed by a conventional multiplex PCR, were selected and used for detecting mutations in the propeller region of the pfk13 gene by Sanger sequencing using Big Dye Terminator method. Regional variations in the proportions of PfK13 mutations were assessed using the chi square or Fisher’s exact tests while Kruskal-Wallis test was used to compare absolute parasite DNA levels between wild type and mutants parasites.
Results: Overall, 238/240 samples (99.2%) contained sufficient DNA and were successfully sequenced. Three mutations were identified within the sequenced samples; PfK13 C469Y in 32/238 (13.5%) samples, PfK13 A675V in 14/238 (5.9%) and PfK13 S522C in (1/238 (0.42%) samples across the four surveyed regions. The prevalence of PfK13 C469Y mutation was significantly higher in Karamoja region (23.3%) compared to other regions, P=0.007. Majority of parasite isolates circulating in West Nile are of wild type (100%), P=0.002. Relative parasite DNA quantity did not differ in samples carrying the wild type, C469Y and A675V alleles (Kruskal-Wallis test, p=0.6373).
Conclusion: The prevalence of validated markers of artemisinin resistance PfK13 A675V and PfK13 C469Y in multiple geographical locations in this high transmission setting provides additional evidence for the emerging threat of artemisinin resistance in Uganda. In view of these findings, country-specific artemisinin resistance management strategy should be developed including periodic genomic surveillance to detect and monitor levels of PfK13 mutations in other regions in parallel with in-vivo therapeutic efficacy studies (TES) to assess potential implication on delayed parasite clearance and associated treatment failure in this setting.
SARS-CoV-2 Phylointeractomics Reveal Functional Evolution of Its Variants Across Susceptible Human Organs
Authors: Li Xu , Wu Peihan , Bao Danqi , Guo Zhihao , Jiang Hua , Sui Yue , Bian Weixiang , Wang Shuai , Zhang Fa , Wu Jianbo , Zhu Yunkai , He Jiaying , Jiang Weiyu , Deng Xiya , Zheng Tingting , Zhang Rong , Wang Peihui , Wang Qiao 
Published: April 2024

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mainly infects the tissues of the human respiratory, nervous, digestive and urinary systems. Here, we conducted an integrated study of the viral–host protein‒protein interactions between 29 wildtype SARS-CoV-2 proteins and 15 SARS-CoV-2 variant S proteins and human lung-, bronchus-, neuron-, liver- and kidney-derived cells, identified 745,163 viral–host protein‒protein interactions and established phylointeractomics of SARS-CoV-2 variants across susceptible human organs. We highlighted interacting proteins involved in the function evolution of viral proteins under different cellular contexts, and identified several as potential drug targets for treating related complications and sequalae. The results reveal how various viral proteins contribute to the infection, replication and immune evasion by interacting with general and cell type-specific host proteins.