bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modification of cellulose fabrics with reactive polyhedral oligomeric silsesquioxanes to improve their shape‐memory performance
Authors: Xie Kongliang , Liu Xu , Zhang Yanli 
Published: June 2010

AbstractReactive polyhedral oligomeric silsesquioxane (R‐POSS) containing multi‐N‐methylol is a functional and attractive staring monomer for new reinforcement materials. R‐POSS has excellent potential as a nanosized core for starburst dendrimers and highly reactive multi‐N‐methylol. R‐POSS can be used for cellulose fabric finishing to improve its shape‐memory performance. Factors affecting the crosslinking reaction of the cellulose with R‐POSS were investigated. The physical properties and morphological structure of the cellulose fabrics modified with R‐POSS are discussed with respect to the crease recovery angle, the whiteness index, micro‐Fourier transform infrared spectroscopy, and scanning electron microscopy. The results show that the crease recovery angle of the fabric modified with R‐POSS obviously increased. With increasing R‐POSS concentration, the crease recovery angle of the modified fabric sharply increased. R‐POSS readily crosslinked to cellulose and improved the elastic recovery of the cellulose fabrics. The surfaces of the cellulose fibers modified with R‐POSS were smooth and full. The inclusion of R‐POSS with dimethylol dihydroxyl ethylene urea to modify the cellulose showed very interesting results. It showed a good combination of an increase of crease recovery angle and a decrease in tensile strength. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Protective targeting of high mobility group box chromosomal protein 1 in a spontaneous arthritis model
Authors: Östberg Therese , Kawane Kohki , Nagata Shigekazu , Yang Huan , Chavan Sangeeta , Klevenvall Lena , Bianchi Marco E. , Harris Helena Erlandsson , Andersson Ulf , Palmblad Karin 
Published: June 2010

AbstractObjectiveHigh mobility group box chromosomal protein 1 (HMGB‐1) is a DNA binding nuclear protein that can be released from dying cells and activated myeloid cells. Extracellularly, HMGB‐1 promotes inflammation. Clinical and experimental studies demonstrate that HMGB‐1 is a pathogenic factor in chronic arthritis. Mice with combined gene deficiency for DNase II and IFNRI spontaneously develop chronic, destructive polyarthritis with many features shared with rheumatoid arthritis. DNase II is needed for macrophage degradation of engulfed DNA. The aim of this study was to evaluate a potential pathogenic role of HMGB‐1 in this novel murine model.MethodsThe course of arthritis, assessed by clinical scoring and histology, was studied in DNase II−/− × IFNRI−/− mice, in comparison with heterozygous and wild‐type mice. Synovial HMGB‐1 expression was analyzed by immunohistochemistry. Serum levels of HMGB‐1 were determined by Western immunoblotting and enzyme‐linked immunosorbent assay (ELISA), and anti–HMGB‐1 autoantibodies were detected by ELISA. Macrophage activation was studied by immunostaining for intracellular interleukin‐1β and HMGB‐1. HMGB‐1 was targeted with truncated HMGB‐1–derived BoxA protein, acting as a competitive antagonist, with intraperitoneal injections every second day for 5 weeks.ResultsDNase II−/− × IFNRI−/− mice developed symmetric polyarthritis with strong aberrant cytosolic and extracellular HMGB‐1 expression in synovial tissue, in contrast to that observed in control animals. Increased serum levels of HMGB‐1 and HMGB‐1 autoantibodies were recorded in DNase II−/− × IFNRI−/− mice, both prior to and during the establishment of disease. Systemic HMGB‐1–specific blockade significantly ameliorated the clinical disease course, and a protective effect on joint destruction was demonstrated by histologic evaluation.ConclusionHMGB‐1 is involved in the pathogenesis of this spontaneous polyarthritis, and intervention with an HMGB‐1 antagonist can mediate beneficial effects.
HLA–DR1001 presents “altered‐self” peptides derived from joint‐associated proteins by accepting citrulline in three of its binding pockets
Authors: James Eddie A. , Moustakas Antonis K. , Bui John , Papadopoulos George K. , Bondinas George , Buckner Jane H. , Kwok William W. 
Published: June 2010

AbstractObjectiveHLA–DRB1*1001 (DR1001) is a shared epitope allele associated with rheumatoid arthritis (RA). The present study was undertaken to assess the capacity of DR1001 to accommodate citrulline in its binding pockets and to identify citrullinated T cell epitopes derived from joint‐associated proteins.MethodsThe binding of peptide derivatives containing citrulline, arginine, and other amino acid substitutions was measured. A prediction algorithm was developed to identify arginine‐containing sequences from joint‐associated proteins that preferentially bind to DR1001 upon citrullination. Unmodified and citrullinated versions of these sequences were synthesized and were utilized to stimulate CD4+ T cells from healthy subjects and RA patients. Responses were measured by class II major histocompatibility complex tetramer staining and confirmed by isolating CD4+ T cell clones.ResultsDR1001 accepted citrulline, but not arginine, in 3 of its anchoring pockets. The prediction algorithm identified sequences that preferentially bound to DR1001 with arginine replaced by citrulline. Three of these sequences elicited CD4+ T cell responses. T cell clones specific for these sequences proliferated only in response to citrullinated peptides.ConclusionConversion of arginine to citrulline generates “altered‐self” peptides that can be bound and presented by DR1001. Responses to these peptides implicate the corresponding proteins (fibrinogen α, fibrinogen β, and cartilage intermediate‐layer protein) as relevant antigens. The finding of preferential responses to citrullinated sequences suggests that altered peptide binding affinity due to this posttranslational modification may be an important factor in the initiation or progression of RA. As such, measuring responsiveness to these peptides may be useful for immunologic monitoring.
The role of impulses in shaping decisions
Authors: Avrahami Judith , Kareev Yaakov 
Published: June 2010

AbstractThis paper explores the extent to which decision behavior is shaped by short‐lived reactions to the outcome of the most recent decision. We inspected repeated decision‐making behavior in two versions of each of two decision‐making tasks, an individual task and a strategic one. By regressing behavior onto the outcomes of recent decisions, we found that the upcoming decision was well predicted by the most recent outcome alone, with the tendency to repeat a previous action being affected both by its actual outcome and by the outcomes of actions not taken. Because the goodness of predictions based on the most recent outcome did not diminish as participants gained experience with the task, we conclude that repeated decisions are continuously affected by impulsive reactions. Copyright © 2010 John Wiley & Sons, Ltd.
Modulation of signal transduction in cancer cells by phytosterols
Authors: Bradford Peter G. , Awad Atif B. 
Published: June 2010

AbstractPhytosterols are biofactors found enriched in plant foods such as seeds, grains, and legumes. Their dietary consumption is associated with numerous health benefits. Epidemiologic and experimental animal studies indicate that phytosterols are cancer chemopreventive agents particularly against cancers of the colon, breast, and prostate. Phytosterols impede oncogenesis and prevent cancer cell proliferation and survival. The molecular mechanisms underlying these beneficial actions involve effects on signal transduction processes which regulate cell growth and apoptosis. Phytosterols increase sphingomyelin turnover, ceramide formation, and liver X receptor activation. In concert, these actions slow cell cycle progression, inhibit cell proliferation, and activate caspase cascades and apoptosis in cancer cells. © 2010 International Union of Biochemistry and Molecular Biology, Inc.
Sulforaphane induces glutathione S‐transferase isozymes which detoxify aflatoxin B1‐8,9‐epoxide in AML 12 cells
Authors: Gao Shang Shang , Chen Xiao Yan , Zhu Ri Zhe , Choi Byung‐Min , Kim Bok‐Ryang 
Published: June 2010

AbstractThe aflatoxin B1‐8,9‐epoxide (AFBO) is hepatocarcinogenic intermediate of aflatoxin B1 (AFB1) and is detoxified by glutathione S‐transferases (GSTs). In this study, we investigated whether sulforaphane (SFN) could increase the rate of conjugation between AFBO and glutathione (GSH) as well as which of the GST isozymes were involved in the conjugation reaction. The conjugation potential was inhibited dose dependently with curcumin, an inhibitor of GSTs. SFN induced the expression of GST A3, GST A4, GST M1, GST P1, and GST T1 in alpha mouse line (AML) 12 cells. The cells treated with SFN (10 μM) for 12 h showed a 35‐fold increase in conjugation potential of AFBO with GSH compared with the vehicle‐treated cell. The conjugation potential was blocked partially by transfection of cells with siRNAs against each of the GST isozymes. The activity of GST A3 had the strongest effect on the conjugation potential. SFN treatment also increased total GST activity detected with 1‐chloro‐2,4‐dinitrobenzene (CDNB) up to 4.3‐fold. The induction fold was much lower than that detected with AFBO. These results suggest that the chemopreventive effect of SFN on the decomposition of AFBO is related to the upregulation of several GST isozymes genes. The increase of GST activity by SFN was extremely specific toward the conjugation reaction of AFBO compared with CDNB. Therefore, this system for detecting GST activity seems to be an excellent method for screening chemopreventive compounds toward AFB1 toxicity.
MT1‐MMP and integrins: Hand‐to‐hand in cell communication
Authors: Gonzalo Pilar , Moreno Vanessa , Gálvez Beatriz G. , Arroyo Alicia G. 
Published: June 2010

AbstractIntegrins are transmembrane adhesion receptors essential for cell communication with the environment and in particular with the extracellular matrix (ECM). ECM components can be processed by several enzymes; one of the largest families involved in this task being matrix metalloproteinases (MMPs). MT1‐MMP (membrane type 1‐matrix metalloproteinase) is a membrane‐anchored MMP with important roles in processes such as tissue development, tumor invasion, and angiogenesis. In addition to its catalytic‐dependent functions, MT1‐MMP can interact, via its cytosolic tail, with intracellular components, and trigger signaling pathways that impact cell decisions. These features make MT1‐MMP similar to integrins, because both are able to integrate events in the extracellular and intracellular milieus. Accordingly, it is probably no coincidence that MT1‐MMP often associates and functionally cooperates with distinct integrins at specific cellular compartments. In this review, we discuss aspects of the molecular and functional interplay between MT1‐MMP and integrins in distinct cellular and biological contexts.
Proteomic analysis of chondrocytes exposed to pressure
Authors: Juang Yu‐Min , Lee Chun‐Yi , Hsu Wei‐Yi , Lin Chiung‐Tsung , Lai Chien‐Chen , Tsai Fuu‐Jen 
Published: June 2010

AbstractChondrocytes are the only cell type present in mature articular cartilage (2–5% of total tissue). The biological activities of the chondrocyte population are regulated by genetic, biologic and biochemical factors, as well as environmental factors (stress, flow and electric field). Although compressive forces within joint articular cartilage are required for maintenance of the normal composition of articular cartilage, there is a lack of knowledge about the number of pressure‐related proteins expressed in articular cartilage. Two‐dimensional gel electrophoresis (2‐DE) and high‐performance liquid chromatography–electrospray/tandem mass spectrometry (HPLC/ESI‐MS/MS) were used to identify the levels of pressure‐related proteins expressed by chondrocytes grown in the presence or absence of hydrostatic pressure. A total of 266 spots were excised from the gels and analyzed by HPLC/ESI‐MS/MS. Functional classification of up‐regulated proteins indicated that energy and protein fate were the main biological processes occurring in pressurized chondrocytes. Furthermore, membrane‐bound transferrin‐like protein p97, a marker of chondrocyte differentiation, was only expressed in chondrocytes under hydrostatic pressure. These data suggest that hydrostatic pressure can induce cell differentiation by increasing the expression level of energy metabolism‐ and protein fate‐related proteins, indicating that hydrostatic pressure may be needed for normal biosynthesis and differentiation of articular chondrocytes. Copyright © 2010 John Wiley & Sons, Ltd.
ChemInform Abstract: Conductivity, Thermal Measurements, X‐Ray Investigations, and Phase Diagram of the Na2S2O7—K2S2 O7 System.
Authors: Rasmussen S. B. , Eriksen K. M. , Hatem G. , da Silva F. , Staahl K. , Fehrmann R. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Binary System Re—Al
Authors: Schuster Julius C. , Perring Loic , Richter Klaus W. , Ipser Herbert , Grin Yuri , Weitzer Franz 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: [Co(en)3] [B2P3O11(OH)2]: A Novel Borophosphate Templated by a Transition‐Metal Complex.
Authors: Yang Guo‐Yu , Sevov Slavi C. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mechanistic and Stereochemical Aspects of the Lewis Acid Mediated Cleavage of α‐Aminoacetals.
Authors: Graham Mark A. , Wadsworth Alan H. , Thornton‐Pett Mark , Carrozzini Benedetta , Cascarano Giovanni L. , Rayner Christopher M. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Lewis Acid Catalyzed Intramolecular Diels—Alder Reactions of Acyclic (Z)‐Substituted 1,3‐Dienes.
Authors: Yakelis Neal A. , Roush William R. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regioselective Addition of Styrene to 4,5‐Dihydro‐5‐methyl‐3H‐spiro‐[2‐benzazepine‐3,1′‐cyclohexane] N‐Oxide.
Authors: Varlamov A. V. , Turchin K. F. , Chernyshev A. I. , Zubkov F. I. , Borisova T. N. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Intramolecular Diels—Alder Reactions of Citraconamic Acids from Furfurylamines and Citraconic Anhydride: Effects of Substitution in the Furan Ring on Regioselectivity.
Authors: Murali Rajappa , Rao H. Surya Prakash , Scheeren Hans W. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Simple and Efficient Synthesis of Bromine‐Substituted 1,3‐Dienes and 1,3,5‐Cycloheptatriene by Vacuum Pyrolysis of gem‐Dibromocyclopropanes.
Authors: Werstiuk Nick H. , Roy Chandra D. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Synthesis of Functionalized β‐ and γ‐Lactams by Cyclization of Enamides Using Copper(I) or Ruthenium(II).
Authors: Bryans Justin S. , Chessum Nicola E. A. , Parsons Andrew F. , Ghelfi Franco 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Use of Aromatic Radical‐Anions in the Absence of THF. Tandem Formation and Cyclization of Benzyllithiums Derived from the Attack of Homo‐ and Bishomoallyllithiums on α‐Methylstyrenes: Two‐Pot Synthesis of Cuparene.
Authors: Cohen Theodore , Kreethadumrongdat Thanapong , Liu Xiaojun , Kulkarni Vithalanand 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Study of the Orientation of the Thorpe—Ziegler Reaction.
Authors: Shestopalov A. M. , Fedorov A. E. , Belyakov P. A. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Active Oligomeric (Salen)Co Catalysts for Asymmetric Epoxide Ring‐Opening Reactions.
Authors: Ready Joseph M. , Jacobsen Eric N. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Photochemical Reaction of Trihalomethanes with Diphenylamine in Organic Media and Its Analytical Application
Authors: Pal Anjali , Bandyopadhyay Manas 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Functionalization of Cycloalkanes: The Photomediated Reaction of Cycloalkanes with Alkynes.
Authors: Geraghty Niall W. A. , Hannan John J. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Multiparameter flow cytometry for the diagnosis and monitoring of small GPI‐deficient cellular populations
Authors: Battiwalla Minoo , Hepgur Mehmet , Pan Dalin , McCarthy Philip L. , Ahluwalia Manmeet S. , Camacho Susan H. , Starostik Petr , Wallace Paul K. 
Published: June 2010

AbstractBackground:Glycosyl‐phosphatidylinositol (GPI)‐negative blood cells are diagnostic for Paroxysmal Nocturnal Hemoglobinuria (PNH). Marrow failure states are often associated with GPI‐negative cell populations. Quantification of small clonal populations of GPI‐negative cells influences clinical decisions to administer immunosuppressive therapy in marrow failure states (aplastic anemia or myelodysplastic syndrome) and to monitor minimal residual disease after allogeneic blood or marrow transplantation (BMT). We studied the reliability of high‐resolution flow cytometry markers operating at the limits of detection.Methods:We performed serial quantification of the PNH clone size in 38 samples using multiparameter flow cytometry. Granulocytes, monocytes, and RBCs were gated using forward and side scatter as well as lineage‐specific markers. The GPI‐linked markers fluorescent aerolysin (FLAER), CD55, and CD59 were comparatively evaluated. We also evaluated CD16 on granulocytes and CD14 on monocytes. The sensitivity of detection by each marker was further defined by serial dilution experiments on a flow‐sorted sample. Two patients had quantification of their GPI‐negative clones before and after allogeneic BMT.Results:FLAER was the most discriminant marker and allowed identification of 0.1% of GPI‐negative cells despite other markers having superior signal‐to‐noise characteristics. CD14 and CD16 were inferior to CD55 at lower concentrations and in clinical application.Conclusions:Multiparameter flow cytometry permits quantification of small GPI‐negative clones with a sensitivity limit of about 0.1%. The single most reliable marker to monitor small granulocyte or monocyte PNH clones is FLAER, especially in conditions such as myelodysplastic syndromes or BMT, when traditional GPI‐linked surface marker expression can be significantly altered. © 2010 International Clinical Cytometry Society
Chiral capillary electrophoresis in food analysis
Authors: Herrero Miguel , Simó Carolina , García‐Cañas Virginia , Fanali Salvatore , Cifuentes Alejandro 
Published: June 2010

AbstractThis review article addresses the different chiral capillary electrophoretic methods used to study and characterize foods and beverages through the enantiomeric separation of different food compounds such as amino acids, pesticides, polyphenols, etc. This work intends to provide an updated overview on the main applications of such enantioselective procedures together with their main advantages and drawbacks in food analysis. Some foreseeable applications and developments of these chiral CZE, CEC and MEKC methods for food characterization are also discussed. Papers that were published within the period January 2003 to October 2009 are included, following the previous review on this topic by Simo et al. (Electrophoresis 2003, 24, 2431–2441).