bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stunting and its association with education and cognitive outcomes in adulthood: A longitudinal study in Indonesia
Authors: Lestari Esta , Siregar Adiatma , Hidayat Achmad K. , Yusuf Arief A. 
Published: May 2024

Background
Stunting is associated with adverse outcomes in adulthood. This article specifically aims to analyse the relationship between childhood stunting and education as well as cognitive outcomes for adults in Indonesia.

Methods
Pooled data from wave one (1) and two (2) of the Indonesia Family Life Survey (IFLS) in 1993 and 1997 identified a sub-sample of 4,379 children aged 0–5 by their height-for-age (HAZ) to be compared for their differences in educational outcomes and cognitive abilities in 2014. HAZ was used to proxy relative height to determine stunting status based on 2006 WHO child’s growth standards. Education and cognitive abilities outcomes include years of schooling, age of school entry, grade repetition, and scores for cognitive and math tests. The study employs estimation models of pooled regressions and instrumental variable (IV) to address problems of endogeneity and bias from omitted variables.

Results
Stunting and relatively small stature had significant associations with cognitive development, and they worked as intermediaries to cognitive developmental barriers as manifested in reduced educational outcomes. A lack of one SD in HAZ was associated with 0.6 years shortened length of the school, 3% higher chances of dropouts from secondary school, and 0.10–0.23 SD lowered cognitive and numerical scores. Similarly, stunting is associated with decrease cognitive test scores by 0.56–0.8 SD compared to non-stunting, two years less schooling, and 0.4 years of delayed entry to school. As for cognitive abilities, stunting is associated with lower cognitive and numerical abilities by 0.38–0.82 z-scores.

Conclusion
Growth retardation during childhood in Indonesia was associated with lower cognitive abilities, particularly during school age, and this correlation faded as individuals grew up. Subsequently, growth retardation is significantly linked to lower educational outcomes. Impaired growth has implications for reduced lifetime earnings potential mediated by diminished cognitive capacity and lower educational attainment. The finding suggests that development in Indonesia during recent decades has not provided an adequate environment to enable children to achieve their potential educational outcomes.
Risk of deep venous thrombosis associated with peripherally inserted central catheter: A retrospective cohort study of 11.588 catheters in Brazil
Authors: Silva Telma Christina do Campo , Braga Luciene Muniz , Vieira Junior Jose Mauro 
Published: May 2024

Introduction
Deep Venous Thrombosis (DVT) due to Peripherally Inserted Central Catheter (PICC) is one of the most threatening complications after device insertion.

Objective
To assess the rate of PICC-associated DVT and analyze the risk factors associated with this event in cancer and critically ill patients.

Methods
We conducted a descriptive, retrospective cohort study with 11,588 PICCs from December 2014 to December 2019. Patients ≥ 18 years receiving a PICC were included. Pre-and post-puncture variables were collected and a logistic regression was used to identify the independent factors associated with the risk of DVT.

Results
The DVT prevalence was 1.8% (n = 213). The median length of PICC use was 15.3 days. The median age was 75 years (18; 107) and 52% were men, 53.5% were critically ill and 29.1% oncological patients. The most common indications for PICC’s were intravenous antibiotics (79.1%). Notably, 91.5% of PICC showed a catheter-to-vein ratio of no more than 33%. The tip location method with intracavitary electrocardiogram was used in 43%. Most catheters (67.9%) were electively removed at the end of intravenous therapy. After adjusting for cancer profile ou chemotherapy, regression anaysis revealed that age (OR 1.011; 95% CI 1.002–1.020), previous DVT (OR 1.96; 95% CI 1.12–3.44) and obstruction of the device (OR 1.60; 95% CI 1.05–2.42) were independent factors associated with PICC-associated DVT, whereas the use of an anticoagulant regimen was a protective variable (OR 0.73; 95% CI 0.54–0.99).

Conclusion
PICC is a safe and suitable intravenous device for medium and long-term therapy, with low rates of DVT even in a cohort of critically ill and cancer patients.
Efficacy and safety of acupuncture treatment for post-stroke depression: A protocol for systematic review and meta-analysis
Authors: Kong Demin , Li Yangyang , Zou Wei 
Published: May 2024

Background
Post-stroke depression is a common complication of stroke, with a high incidence rate and low recognition rate. Many patients do not receive effective intervention at the onset, which affects subsequent treatment outcomes. Post-stroke depression not only impacts the patient’s mental well-being but also increases the risk of stroke recurrence and poor prognosis. Therefore, it has become a significant public health concern. Acupuncture has gained significant popularity in the treatment of post-stroke depression. However, there are inconsistent clinical research results regarding its efficacy and safety. This systematic review aims to gather and critically assess all available evidence regarding the effectiveness and safety of acupuncture in the treatment of post-stroke depression in patients.

Methods
We will conduct thorough searches for relevant studies in multiple electronic databases (PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, VIP Database, Wan-fang Data and China Biomedical Database). Our search scope will encompass studies published from the inception of each database until September 2023. To evaluate the potential bias in all the included studies, we will adhere to the guidelines offered in the Cochrane Handbook. The total effective rate will be the primary outcome. To conduct a systematic review, we will employ RevMan 5.4 software.

Results
This study will obtain efficacy and safety of acupuncture for the treatment of post-stroke depression.

Conclusions
The conclusions of this study will provide evidence-based perspectives that can guide clinical decision-making regarding the practicality and recommended timing of using acupuncture to treat post-stroke depression. Furthermore, this study will help advance the clinical application of acupuncture treatment for post-stroke depression and enhance its efficacy while ensuring patient safety.
Effect of multiple micronutrient-fortified bouillon on micronutrient status among women and children in the Northern Region of Ghana: Protocol for the Condiment Micronutrient Innovation Trial (CoMIT), a community-based randomized controlled trial
Authors: Engle-Stone Reina , Wessells K Ryan , Haskell Marjorie J. , Kumordzie Sika M. , Arnold Charles D. , Davis Jennie N. , Becher Emily R. , Fuseini Ahmed D. , Nyaaba Kania W. , Tan Xiuping , Adams Katherine P. , Lietz Georg , Vosti Stephen A. , Adu-Afarwuah Seth 
Published: May 2024

Introduction
Micronutrient deficiencies are prevalent in West Africa, particularly among women of reproductive age (WRA) and young children. Bouillon is a promising food fortification vehicle due to its widespread consumption. This study aims to evaluate the impact of multiple micronutrient-fortified bouillon cubes, compared to control bouillon cubes (fortified with iodine only), on micronutrient status and hemoglobin concentrations among lactating and non-lactating WRA and young children in northern Ghana.

Methods
This randomized, controlled doubly-masked trial will be conducted in the Kumbungu and Tolon districts in the Northern Region of Ghana, where prior data indicate multiple micronutrient deficiencies are common. Participants will be: 1) non-pregnant non-lactating WRA (15–49 y), 2) children 2–5 y, and 3) non-pregnant lactating women 4–18 months postpartum. Eligible participants will be randomly assigned to receive household rations of one of two types of bouillon cubes: 1) a multiple micronutrient-fortified bouillon cube containing vitamin A, folic acid, vitamin B12, iron, zinc, and iodine, or 2) a control cube containing iodine only.
Each participant’s household will receive a ration of bouillon cubes every 2 weeks, and households will be advised to prepare meals as usual, using the study-provided cubes. The trial duration will be 9 months for non-pregnant non-lactating WRA and children, and 3 months for lactating women. The primary outcomes will be changes in biomarkers of micronutrient status and hemoglobin among WRA and children and milk micronutrient concentrations among lactating women. Secondary outcomes will include change in prevalence of micronutrient deficiency and anemia; dietary intake of bouillon and micronutrients; inflammation, malaria, and morbidity symptoms; and child growth and development.

Discussion
Evidence from this study will inform discussions about bouillon fortification in Ghana and West Africa.

Trial registration
The trial was registered on ClinicalTrials.gov (NCT05178407) and the Pan-African Clinical Trial Registry (PACTR202206868437931). This manuscript reflects protocol version 4 (August 29, 2022).
Incidence and Impact of Takotsubo Syndrome in Hospitalized Patients With COVID-19
Authors: Li Pengyang , Shi Ao , Lu Xiaojia , Li Chenlin , Cai Peng , Teng Catherine , Wu Lingling , Shu Yuan , Pan Su , Dixon Richard A. F. , Liu Qi , Wang Bin 
Published: May 2024

Abstract

Background:
Takotsubo syndrome has been reported in patients with COVID-19, although minimal data are available. This investigation assessed the incidence and impact of takotsubo syndrome on patients hospitalized with COVID-19.

Methods:
A retrospective cohort study was conducted using International Statistical Classification of Diseases, Tenth Revision, codes to identify patients with a primary diagnosis of COVID-19 with or without takotsubo syndrome in the National Inpatient Sample 2020 database. Outcomes between groups were compared after propensity score matching for patient and hospital demographics and comorbidities.

Results:
A total of 211,448 patients with a primary diagnosis of COVID-19 were identified. Of these, 171 (0.08%) had a secondary diagnosis of takotsubo syndrome. Before matching, patients with COVID-19 and takotsubo syndrome, compared with patients without takotsubo syndrome, were older (68.95 vs 64.26 years; P < .001); more likely to be female (64.3% vs 47.2%; P < .001); and more likely to have anxiety (24.6% vs 12.8%; P < .001), depression (17.5% vs 11.4%; P = .02), and chronic obstructive pulmonary disease (24.6% vs 14.7%; P < .001). The takotsubo syndrome group had worse outcomes than the non–takotsubo syndrome group for death (30.4% vs 11.1%), cardiac arrest (7.6% vs 2.1%), cardiogenic shock (12.9% vs 0.4%), length of hospital stay (10.7 vs 7.5 days), and total charges ($152,685 vs $78,468) (all P < .001). After matching and compared with the non–takotsubo syndrome group (n = 508), the takotsubo syndrome group (n = 170) had a higher incidence of inpatient mortality (30% vs 14%; P < .001), cardiac arrest (7.6% vs 2.8%; P = .009), and cardiogenic shock (12.4% vs 0.4%; P < .001); a longer hospital stay (10.7 vs 7.6 days; P < .001); and higher total charges ($152,943 vs $79,523; P < .001).

Conclusion:
Takotsubo syndrome is a rare but severe in-hospital complication in patients with COVID-19.
Rendemen Minyak Atsiri Rimpang Jahe Merah (Zingiber officinale var. rubrum) dengan Metode Pengeringan yang Dikombinasi dengan Kain Penutup
Authors: Wiraputra Muhammad Dwijunianto , Nurchayati Yulita , Hastuti Endah Dwi , Setiari Nintya 
Published: May 2024

Kualitas jahe merah ditentukan oleh kandungan minyak atsiri yang mudah menguap. Kombinasi cabinet solar dryer (CSD) sebagai alat pengering yang dikombinasikan dengan kain penutup dapat mempengaruhi rendemen minyak atsiri. Penelitian ini bertujuan untuk mempelajari pengaruh kombinasi metode pengeringan dengan penambahan kain penutup terhadap rendemen minyak atsiri jahe merah. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) pola faktorial 2 x 3 dengan 3 ulangan. Faktor pertama adalah pengeringan dengan cabinet solar dryer dan metode terbuka tanpa alat. Faktor kedua adalah tanpa kain, 1 lapis kain dan 2 lapis kain penutup. Parameter yang diamati adalah volume minyak atsiri, rendemen minyak atsiri, kadar air, susut bobot, suhu pengeringan, kelembaban udara, dan morfologi jahe. Metode yang digunakan adalah pengeringan rimpang jahe, yang telah diiris dengan ketebalan 5 mm. Rendemen minyak atsiri dianalisis dengan metode destilasi uap dan air. Hasil penelitian menunjukkan terdapat interaksi antara metode pengeringan dan kain penutup terhadap rendemen minyak atsiri. Rendemen tertinggi (0,98%) diperoleh dengan metode pengeringan matahari langsung dengan 1 lapis kain penutup. Kadar air terendah dan susut bobot tertinggi terdapat pada perlakuan matahari langsung tanpa kain penutup sebesar 13,04% dan 79,93%. Perlakuan optimal dalam meningkatkan volume dan rendemen minyak atsiri diperoleh pada metode pengeringan matahari terbuka dengan 1 lapis kain penutup. Metode pengeringan dengan alat CSD tanpa kain penutup menghasilkan minyak atsiri yang tinggi sebesar 0,6%. The quality of red ginger is determined by its volatile essential oil content. A cabinet solar dryer (CSD) combined with a cloth cover can affect the yield of ginger essential oil. This study aims the effect of the drying method combined with cover cloth on the yield of red ginger essential oil. This study used a completely randomized design (CRD) factorial pattern 2 x 3 with 3 repetitions. The parameters observed were essential oil volume and yield, water content, weight loss, drying temperature, drying humidity, and ginger morphology. The method used was dried rhizome chopped with a thickness of 5 mm. The essential oils were analyzed by steam and water distillation. The results showed that there was an interaction between the two treatments for essential oil yields. The highest essential oil yield (0.98%) was obtained from direct sunlight with 1 layer of cloth. The lowest water content and highest weight loss were found in direct sun without covering cloth at 13.04% and 79.93%. Optimal treatment in increasing oil volume and essential oil yield was obtained by drying in the open sun with 1 layer of cloth cover. Drying with a CSD without a cover cloth produces a high essential oil.
PENERAPAN KONSEP TEKNOLOGI BAHAN BAKAR JUMPUTAN PADAT (BBJP) SEBAGAI UPAYA MENGURANGI KEBUTUHAN LAHAN TEMPAT PEMROSESAN AKHIR SAMPAH CILOWONG, SERANG, BANTEN
Authors: Pirngadi Budi Heri , Ramdhani Zaenal , Pangestu Reza 
Published: May 2024

Timbulan sampah yang tidak sebanding dengan ketersediaan lahan TPA telah menjadi masalah utama pengelolaan sampah di perkotaan. Hal tersebut juga terjadi di Kota dan Kabupaten Serang Provinsi Banten. TPA yang melayani Sampah dari kedua daerah tersebut yaitu TPA Cilowong saat ini sudah melebihi kapasitas. Di sisi lain sampah dari dua daerah tersebut berpotensi untuk dibuat Bahan Bakar Jemputan Padat (BBJP) atau bahan bakar jumputan padat (BBJP). Penelitian ini bertujuan untuk membahas upaya mengurangi kebutuhan lahan TPA dengan mengolah sampah yang masuk ke TPA menjadi BBJP. Metodologi yang digunakan adalah menggunakan metoda kuantitatif. Berdasarkan hasil penelitian diketahui potensi kalor sampah yang masuk ke TPA Cilowong dalam keadaan kering yaitu 5.626,67 kCal/Kg layak untuk dijadikan BBJP. Dengan jumlah sampah setiap hari sebanyak 454 ton/hari maka dapat dihasilkan BBJP sebanyak 136–181 ton setiap harinya. Selain itu, di Kota dan Kabupaten Serang terdapat potensi pemanfaatan BBJP pada lima PLTU dan dua pabrik semen yang saat ini menggunakan batu bara. Dengan mengolah sampah yang masuk ke TPA Cilowong menjadi BBJP maka dapat mengurangi kebutuhan lahan TPA untuk 10 tahun ke depan seluas 67 Ha. Artikel ini memiliki kontribusi bagi bidang ilmu teknik lingkungan dan perencanaan wilayah terutama perencanaan infrastruktur pengelolaan sampah.
The Credit Council in the US Context
Authors: Feldmann John Davis 
Published: May 2024

Abstract
The proper role of central banks – in the US the Federal Reserve – is again up for scrutiny and criticism as the consequences of the monetary policies of the Great Financial Crisis (GFC) are fully revealed. Into the debate comes the proposal of an updated version of the Credit Council, an institution that worked alongside central banks in many European countries in the adjustment from a wartime to a peacetime economy post WWII. The renovated and reconstituted European Credit Council, as conceived by Eric Monnet of the Paris School of Economics, would participate as an aid to both the legislature and central banks in developing and monitoring monetary policy. Monnet sees additional institutional oversight to be essential as central banks confront the multifaceted challenges of escaping from GFC experimental policies and dealing with emerging challenges such as the Green Transition and social inequality. Monnet’s idea has its supporters and critics in the European context. This paper attempts to assess the utility and efficacy of the Credit Council in the US context, using: (i) the EU criticisms to anticipate and respond to likely objections from US critics; and (ii) the current Fed reform debate in the US to gauge potential fit and acceptance. The conclusion, in brief, is that the Monnet CC concept could fit well within the US context and is a potentially useful mechanism for enhancing democratic responsiveness and adding to policy legitimacy as the Fed deals with existing and imminent monetary arena challenges.
Copper oxide nanoparticles-mediated Heliotropium bacciferum leaf extract: Antifungal activity and molecular docking assays against strawberry pathogens
Authors: Hamdy Esraa , El-Gendi Hamada , Al-Askar Abdulaziz , El-Far Ali , Kowalczewski Przemysław , Behiry Said , Abdelkhalek Ahmed 
Published: May 2024

Abstract
In the current study, Heliotropium bacciferum leaf extract was used to biosynthesize copper oxide nanoparticles (CuO-NPs). Various analytical techniques were used to characterize the produced CuO-NPs. Transmission electron microscope investigation indicated well-distributed spherical particles in various development phases. The particles’ diameters ranged from 22.15 to 37.01 nm, with an average of 24.8 ± 6.1 nm. Energy dispersive X-ray examination confirmed the presence of nanoscale Cu ions at a high concentration, as seen by the strong signal peak at 1 keV. Fourier transform infrared spectrum revealed various functional groups on the green-produced CuO-NPs, as evidenced by multiple absorption beaks. The bands found at 3,195 and 2,916 cm−1 revealed that phenolic and flavonoid compounds’ alcohols and alkanes were stretching C–H. Also, a band at 1,034 cm−1 is typically attributed to CuO production. CuO-NPs exhibited significant bioactivity against isolated and molecularly identified fungal strains, including Rhizoctonia solani (OR116528), Fusarium oxysporum (OR116508), and Botrytis cinerea (OR116491). Remarkably, the highest inhibition percentages were recorded at 100 µg/mL, with values 81.48, 71.11, and 50.74% for R. solani, F. oxysporum, and B. cinerea, respectively. Molecular docking interactions revealed that the highest binding affinity of CuO-NPs was −5.1 for the oxidoreductase of B. cinerea and −5.2 and −5.4 for the chitin synthase of R. solani and F. oxysporum, respectively. Consequentially, the biosynthesized CuO-NPs could be employed as antifungal biocontrol agents, as well as using H. bacciferum leaf extract for the synthesis of nanoparticles for various sustainable agricultural applications.
Computerized diagnostic decision support systems – a comparative performance study of Isabel Pro vs. ChatGPT4
Authors: Bridges Joe M. 
Published: May 2024

Abstract

Objectives
Validate the diagnostic accuracy of the Artificial Intelligence Large Language Model ChatGPT4 by comparing diagnosis lists produced by ChatGPT4 to Isabel Pro.

Methods
This study used 201 cases, comparing ChatGPT4 to Isabel Pro. Systems inputs were identical. Mean Reciprocal Rank (MRR) compares the correct diagnosis’s rank between systems. Isabel Pro ranks by the frequency with which the symptoms appear in the reference dataset. The mechanism ChatGPT4 uses to rank the diagnoses is unknown. A Wilcoxon Signed Rank Sum test failed to reject the null hypothesis.

Results
Both systems produced comprehensive differential diagnosis lists. Isabel Pro’s list appears immediately upon submission, while ChatGPT4 takes several minutes. Isabel Pro produced 175 (87.1 %) correct diagnoses and ChatGPT4 165 (82.1 %). The MRR for ChatGPT4 was 0.428 (rank 2.31), and Isabel Pro was 0.389 (rank 2.57), an average rank of three for each. ChatGPT4 outperformed on Recall at Rank 1, 5, and 10, with Isabel Pro outperforming at 20, 30, and 40. The Wilcoxon Signed Rank Sum Test confirmed that the sample size was inadequate to conclude that the systems are equivalent. ChatGPT4 fabricated citations and DOIs, producing 145 correct references (87.9 %) but only 52 correct DOIs (31.5 %).

Conclusions
This study validates the promise of Clinical Diagnostic Decision Support Systems, including the Large Language Model form of artificial intelligence (AI). Until the issue of hallucination of references and, perhaps diagnoses, is resolved in favor of absolute accuracy, clinicians will make cautious use of Large Language Model systems in diagnosis, if at all.
Time-varying Investment Dynamics in the USA
Authors: Mendieta-Muñoz Ivan 
Published: May 2024

Abstract
We study the time-varying effects of Tobin’s q and cash flow on investment dynamics in the USA using a vector autoregression model with drifting parameters and stochastic volatilities estimated via Bayesian methods. We find a significant variation over time of the response of investment to shocks in both variables. The time-varying sensitivity of investment to a shock in Tobin’s q (cash flow) decreased (increased) since the early 1960s through the early 1980s, increased (decreased) since the early 1980s through the early 2000s, and it has decreased (increased) importantly again since then. Thus, the time-varying response of investment to a shock to Tobin’s q has been almost the mirror image to the time-varying response of investment to a shock to cash flow. This implies that Tobin’s q and cash flow represent both complementary and alternative sources of information needed to understand short-run investment behavior.
Ethnic Identity and Traces of Culture: Pema Tseden in a Centenary History of Films
Authors: Wang Haizhou , Yan Wenjun 
Published: May 2024

Abstract
As a Tibetan indie filmmaker, Pema Tseden is endowed with an ethnic advantage. In his films, he focuses on the real-life conditions of Tibetans. Observing ethnic groups through the personal perspective of the individual, he profoundly contemplates the condition of Tibetan culture in the modernized world while reflecting on China through the geographical perspective of borderland. In terms of form, Pema Tseden’s films represent the unique features of Chinese film aesthetics and poetics by adopting special Tibetan images and the implicit narrative structure of blank space.