bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modulation of Nuclear Receptor 4A1 Expression Improves Insulin Secretion in a Mouse Model of Chronic Pancreatitis
Authors: Sheethal Galande , Verma Archana , Mall Raghvendra , Parsa Kishore VL , Tokala Ranjeet K. , Bynigeri Ratnakar , Pondugala Pavan Kumar , Vemula Krishna , Sai Latha S , Sowpati Divya Tej , Singh Surya S. , Rao GV , Talukdar Rupjyoti , Kanneganti Thirumala-Devi , Reddy D Nageshwar , Sasikala Mitnala 
Published: May 2024

Objectives
Diabetes secondary to chronic pancreatitis (CP) presents clinical challenges due to lack of understanding on factor(s) triggering insulin secretory defects. Therefore, we aimed to delineate the molecular mechanism of β-cell dysfunction in CP.

Materials and Methods
Transcriptomic analysis was conducted to identify endocrine-specific receptor expression in mice and human CP on microarray. The identified receptor (NR4A1) was overexpressed in MIN6 cells using PEI linear transfection. RNA-Seq analysis of NR4A1-overexpressed (OE) MIN6 cells on NovaSeq6000 identified aberrant metabolic pathways. Upstream trigger for NR4A1OE was studied by InBio Discover and cytokine exposure, whereas downstream effect was examined by Fura2 AM-based fluorimetric and imaging studies. Mice with CP were treated with IFN-γ-neutralizing monoclonal antibodies to assess NR4A1 expression and insulin secretion.

Results
Increased expression of NR4A1 associated with decreased insulin secretion in islets (humans: controls 9 ± 0.2, CP 3.7 ± 0.2, mice: controls 8.5 ± 0.2, CP 2.1 ± 0.1 μg/L). NR4A1OE in MIN6 cells (13.2 ± 0.1) showed reduction in insulin secretion (13 ± 5 to 0.2 ± 0.1 μg/mg protein per minute, P = 0.001) and downregulation of calcium and cAMP signaling pathways. IFN-γ was identified as upstream signal for NR4A1OE in MIN6. Mice treated with IFN-γ–neutralizing antibodies showed decreased NR4A1 expression 3.4 ± 0.11-fold (P = 0.03), showed improved insulin secretion (4.4 ± 0.2-fold, P = 0.01), and associated with increased Ca2+ levels (2.39 ± 0.06-fold, P = 0.009).

Conclusions
Modulating NR4A1 expression can be a promising therapeutic strategy to improve insulin secretion in CP.
Neural Mechanisms Associated With Postural Control in Collegiate Soccer and Non-Soccer Athletes
Authors: Jain Divya , Porfido Tara , de Souza Nicola L. , Brown Allison M. , Caccese Jaclyn B. , Czykier Anna , Dennis Emily L. , Tosto-Mancuso Jenna , Wilde Elisabeth A. , Esopenko Carrie 
Published: May 2024

Background and Purpose:
Sport-specific training may improve postural control, while repetitive head acceleration events (RHAEs) may compromise it. Understanding the neural mechanisms underlying postural control may contextualize changes due to training and RHAE. The goal of this study was to determine whether postural sway during the Balance Error Scoring System (BESS) is related to white matter organization (WMO) in collegiate athletes.

Methods:
Collegiate soccer (N = 33) and non-soccer athletes (N = 44) completed BESS and diffusion tensor imaging. Postural sway during each BESS stance, fractional anisotropy (FA), and mean diffusivity (MD) were extracted for each participant. Partial least squares analyses determined group differences in postural sway and WMO and the relationship between postural sway and WMO in soccer and non-soccer athletes separately.

Results:
Soccer athletes displayed better performance during BESS 6, with lower FA and higher MD in the medial lemniscus (ML) and inferior cerebellar peduncle (ICP), compared to non-soccer athletes. In soccer athletes, lower sway during BESS 2, 5, and 6 was associated with higher FA and lower MD in the corticospinal tract, ML, and ICP. In non-soccer athletes, lower sway during BESS 2 and 4 was associated with higher FA and lower MD in the ML and ICP. BESS 1 was associated with higher FA, and BESS 3 was associated with lower MD in the same tracts in non-soccer athletes.

Discussion and Conclusions:
Soccer and non-soccer athletes showed unique relationships between sway and WMO, suggesting that sport-specific exposures are partly responsible for changes in neurological structure and accompanying postural control performance and should be considered when evaluating postural control after injury.

Video Abstract available for more insights from the authors (see the Video, Supplemental Digital Content, available at: http://links.lww.com/JNPT/A472).
Examination of Pain Comorbid Diagnoses in the Inpatient Rehabilitation Population Across All Impairment Groups
Authors: Curry Zachary A. , Andrew Michael N. , Chiang Michael C. , Goldstein Richard , Zafonte Ross , Ryan Colleen M. , Coleman Brian C. , Schneider Jeffrey C. 
Published: May 2024

Abstract

Objective
Pain is common in inpatient rehabilitation patients; however, the prevalence of pain diagnoses in this population is not well-defined. This study examines comorbid pain diagnoses in inpatient rehabilitation patients across impairment groups.

Design
Adult inpatient rehabilitation patients discharged from January 2016 through December 2019 were identified in the Uniform Data System for Medical Rehabilitation database using a literature-established framework containing International Classification of Diseases, Tenth Revision, Clinical (ICD-10-CM) pain diagnoses. Demographic data, clinical data, and pain diagnoses were compared across the 17 rehabilitation impairment groups.

Results
Of 1,925,002 patients identified, 1,347,239 (70.0%) had at least one International Classification of Diseases, Tenth Revision (ICD-10) pain diagnosis. Over half of all patients in each impairment group had at least one pain diagnosis. The most common pain diagnoses were limb/extremity and joint pain, with variation between impairment groups. Female sex and being in the arthritis, major multiple trauma, and pain syndrome impairment groups were associated with a greater odds of a pain diagnosis.

Conclusions
Over half of all patients in each rehabilitation impairment group have a pain diagnosis, which varies between impairment groups. Because of the high prevalence of pain diagnoses, a new focus on pain management in inpatient rehabilitation patients is needed. Rehabilitation outcomes may also be affected by pain.
Diagnostic Ultrasound in the Evaluation of Stiff Shoulder
Authors: Yao Buwen , Yang Yanyan , Roll Shawn C. , Lin Zhuohua , Zhang Yuanmingfei , Jiang Jie , Zhou Mouwang 
Published: May 2024

Objectives
Stiff shoulder, including primary and secondary types, poses diagnostic challenges due to vague definitions and criteria. This study evaluates the diagnostic potential of ultrasound-measured axillary recess thickness in shoulder stiffness.

Designs
In this cross-sectional study, 35 patients with unilateral shoulder stiffness were assessed. Axillary recess thickness was measured using high-resolution ultrasound. Parameters like passive range of motion, Numerical Rating Scale, and Constant-Murley score were evaluated to find correlations with axillary recess thickness.

Results
The average age was 50.7 yrs, and mean body mass index was 22.7. Axillary recess thickness in stiff shoulders (average 3.19 mm) was significantly higher than in unaffected shoulders (average 1.93 mm, P < 0.001). A cutoff of 3.0 mm for axillary recess thickness yielded 73.3% sensitivity and 84.6% specificity for primary stiffness; 2.6 mm cutoff resulted in 57.9% sensitivity and 88.2% specificity for secondary stiffness. Significant correlations were found between axillary recess thickness and passive range of motion, especially in shoulder external rotation and extension.

Conclusions
Axillary recess thickness measured by ultrasound might serve as a valuable diagnostic and evaluation parameter in shoulder stiffness.
Safety and Immunogenicity of a DNA Vaccine With Subtype C gp120 Protein Adjuvanted With MF59 or AS01B: A Phase 1/2a HIV-1 Vaccine Trial
Authors: Garrett Nigel , Dintwe One , Monaco Cynthia L. , Jones Megan , Seaton Kelly E. , Church E. Chandler , Grunenberg Nicole , Hutter Julia , deCamp Allan , Huang Yunda , Lu Huiyin , Mann Philipp , Robinson Samuel T. , Heptinstall Jack , Jensen Ryan L. , Pantaleo Giuseppe , Ding Song , Koutsoukos Marguerite , Hosseinipour Mina C. , Van Der Meeren Olivier , Gilbert Peter B. , Ferrari Guido , Andersen-Nissen Erica , McElrath M. Juliana , Tomaras Georgia D. , Gray Glenda E. , Corey Lawrence , Kublin James G. ,   on behalf of the HVTN 108 and HVTN 111 Study Teams
Published: May 2024

Background:
An effective vaccine is required to end the HIV pandemic. We evaluated the safety and immunogenicity of a DNA (DNA-HIV-PT123) vaccine with low- or high-dose bivalent (TV1.C and 1086.C glycoprotein 120) subtype C envelope protein combinations, adjuvanted with MF59 or AS01B.

Methods:
HIV Vaccine Trials Network (HVTN)108 was a randomized, placebo-controlled, double-blind, phase 1/2a trial conducted in the United States and South Africa. HIV-negative adults were randomly assigned to 1 of 7 intervention arms or placebo to assess DNA prime with DNA/protein/adjuvant boosts, DNA/protein/adjuvant co-administration, and low-dose protein/adjuvant regimens. HVTN111 trial participants who received an identical regimen were also included. Outcomes included safety and immunogenicity 2 weeks and 6 months after final vaccination.

Results:
From June 2016 to July 2018, 400 participants were enrolled (N = 334 HVTN108, N = 66 HVTN111); 370 received vaccine and 30 received placebo. There were 48 grade 3 and 3 grade 4 reactogenicity events among 39/400 (9.8%) participants, and 32 mild/moderate-related adverse events in 23/400 (5.8%) participants. All intervention groups demonstrated high IgG response rates (>89%) and high magnitudes to HIV-1 Env gp120 and gp140 proteins; response rates for AS01B-adjuvanted groups approached 100%. V1V2 IgG magnitude, Fc-mediated functions, IgG3 Env response rates, and CD4+ T-cell response magnitudes and rates were higher in the AS01B-adjuvanted groups. The AS01B-adjuvanted low-dose protein elicited greater IgG responses than the higher protein dose.

Conclusions:
The vaccine regimens were generally well tolerated. Co-administration of DNA with AS01B-adjuvanted bivalent Env gp120 elicited the strongest humoral responses; AS01B-adjuvanted regimens elicited stronger CD4+ T-cell responses, justifying further evaluation.
ClinicalTrials.gov registration: NCT02915016, registered 26 September 2016.
Postoperative Extremity Tomosynthesis—A Superimposition-Free Alternative to Standard Radiography?
Authors: Grunz Jan-Peter , Kunz Andreas Steven , Paul Mila Marie , Luetkens Karsten Sebastian , Huflage Henner , Conrads Nora , Ergün Süleyman , Weber Thomas , Herbst Magdalena , Herold Sophia , Bley Thorsten Alexander , Patzer Theresa Sophie 
Published: May 2024

Rationale and Objectives
This study investigates the performance of tomosynthesis in the presence of osteosynthetic implants, aiming to overcome superimposition-induced limitations in conventional radiograms.

Materials and Methods
After surgical fracture induction and subsequent osteosynthesis, 8 cadaveric fracture models (wrist, metacarpus, ankle, metatarsus) were scanned with the prototypical tomosynthesis mode of a multiuse x-ray system. Tomosynthesis protocols at 60, 80, and 116 kV (sweep angle 10°, 13 FPS) were compared with standard radiograms. Five radiologists independently rated diagnostic assessability based on an equidistant 7-point scale focusing on fracture delineation, intra-articular screw placement, and implant positioning. The intraclass correlation coefficient (ICC) was calculated to analyze interrater agreement.

Results
Radiation dose in radiography was 0.48 ± 0.26 dGy·cm2 versus 0.12 ± 0.01, 0.36 ± 0.02, and 1.95 ± 0.11 dGy·cm2 for tomosynthesis scans at 60, 80, and 116 kV. Delineation of fracture lines was superior for 80/116 kV tomosynthesis compared with radiograms (P ≤ 0.003). Assessability of intra-articular screw placement was deemed favorable for all tomosynthesis protocols (P ≤ 0.004), whereas superiority for evaluation of implant positioning could not be ascertained (all P's ≥ 0.599). Diagnostic confidence was higher for 80/116 kV tomosynthesis versus radiograms and 60 kV tomosynthesis (P ≤ 0.002). Interrater agreement was good for fracture delineation (ICC, 0.803; 95% confidence interval [CI], 0.598–0.904), intra-articular screw placement (ICC, 0.802; 95% CI, 0.599–0.903), implant positioning (ICC, 0.855; 95% CI, 0.729–0.926), and diagnostic confidence (ICC, 0.842; 95% CI, 0.556–0.934).

Conclusions
In the postoperative workup of extremity fractures, tomosynthesis allows for superior assessment of fracture lines and intra-articular screw positioning with greater diagnostic confidence at radiation doses comparable to conventional radiograms.
Evaluation of Clinical Success of the 3D-Printed Custom-Made Subperiosteal Implants
Authors: Ayhan Mustafa , Ozturk Muhtar Merve , Kundakcioglu Abdulsamet , Kucukcakir Osman , Cansiz Erol 
Published: May 2024

Objective:
The authors aim to share their experiences in subperiosteal implant applications in atrophic jaws, which have been practiced in their clinic for about 2 years, and evaluate the complications and clinical success of the implants.

Material and method:
Clinical and radiologic data of 32 patients who underwent subperiosteal implantation for advanced alveolar bone loss were evaluated, but 1 patient was excluded as they smoked. Of the 31 patients included in the study, 27 were operated with the diagnosis of total tooth loss, 3 for maxillectomy and 1 for partial tooth loss. A total of 60 subperiosteal implants were placed in them. The mean follow-up period was 15 months.

Results:
During the operation, implant-bone adaptation problems were encountered in 11 patients, implant skeletal fracture in 1 patient, and loss of primary stabilization during mini-screw fixation in 2. Although there were no complications in the early postoperative period, biological and prosthetic complications occurred in the late postoperative period. Soft tissue retraction at various levels in 12 patients (only keratinized tissue retraction in 6 and mucosal retraction exceeding keratinized tissue in 6), soft tissue infection in 5 and oroantral fistula development in 1, mini-screw loosening in 3 were the biological complications that occurred.

Conclusions:
Various complications may occur during or after the application of custom-made subperiosteal implants. However, these are manageable and can be reapplied in case of a possible implant loss, making it an important alternative, especially in atrophic jaws where endosseous dental implants cannot be applied.
Could Cerebral Inflammatory Lesions be the Cellular Origin of Primary Central Nervous System Lymphoma?
Authors: Ma Jie , Zhang Jianning , Chen Tao , Bai Hongmin , Yu Xinguang , Wang Hongwei 
Published: May 2024

Introduction:
Primary central nervous system lymphoma (PCNSL) presents a diagnostic enigma due to the inherent absence of lymphoid tissue in the central nervous system (CNS). The hypothesis posits that lymphocytes infiltrating the CNS during inflammatory responses could represent a cellular source for PCNSL, challenging traditional understandings of its etiology.

Patient concerns:
In 2 illustrative cases, patients presented with neurological symptoms initially misdiagnosed as encephalitis and demyelinating disease, respectively. These diagnoses were established based on clinical assessments and initial biopsy findings.

Diagnosis:
Subsequent biopsies, conducted months after the first signs of disease, confirmed the diagnosis of PCNSL in both patients. Identifying CD20-positive tumor cells was pivotal, indicating a B-cell lymphoma origin.

Interventions:
Treatment strategies included high-dose methotrexate chemotherapy for both patients. In addition, the second patient underwent adjuvant whole-brain radiotherapy after the chemotherapy regimen.

Outcomes:
The therapeutic approach significantly reduced tumor size in both cases, with no evidence of recurrence observed during the follow-up period. This outcome underscores the potential efficacy of the chosen interventions.

Conclusion:
In response to inflammatory lesions, lymphocyte infiltration into the CNS may serve as a pivotal origin for tumor cells in PCNSL. These cases highlight the complexity of diagnosing CNS disorders and suggest that various forms of encephalitis in the early stages could influence the prognosis of lymphoma. This insight into the cellular origins and treatment responses of PCNSL contributes to a broader understanding of its pathophysiology and management.
An Effective Technique for the Correction of Orbital Hypertelorism to Prevent Recurrence
Authors: Dong Guoxuan , Gu Tianyi , Zhang Chao , Teng Li 
Published: May 2024

Objective:
To investigate the efficacy and safety of medial orbital wall osteotomy with medial displacement combined with lateral orbital wall Medpor artificial material implantation in the treatment of orbital hypertelorism.

Methods:
A retrospective analysis was performed on patients who underwent the above surgical procedures from 2010 to 2019, and long-term follow-up was conducted to record surgery-related complications and evaluate postoperative outcomes.

Results:
Four patients (3 males and 1 female) were followed up for 24 months. All patients were satisfied with the postoperative results. There was no diplopia, vision loss, eye movement disorder or other vision-related complications. There was no implant rejection, infection or exposure.

Conclusion:
This operation is a modification of the traditional surgical method of medial orbital wall osteotomy. It is safe and effective for the treatment of orbital hypertelorism.
Relation of Mandibular Canal Discontinuity and IAN Paresthesia in Operated Cases of Mandibular Fracture
Authors: Sahoo Nanda Kishore , Vashisht Sahil , Vaswani Himani , Pandey Swati 
Published: May 2024

Introduction:
Mandibular fractures are common in maxillofacial trauma, often requiring surgical intervention for optimal recovery. One critical concern during such procedures is the potential for nerve damage, specifically involving the mandibular canal. This study aims to investigate whether the presence of postoperative mandibular canal discontinuity is associated with an increased risk of nerve damage.

Methodology:
A retrospective analysis was conducted on a cohort of 72 postoperative mandibular fracture patients. In total, 58 patients had entire mandibular canal continuity, while 14 showed discontinuity. Clinical records and follow-up data were examined to assess the occurrence of nerve injury. Statistical analysis was performed to determine the significance of any correlation.

Results:
Of the 14 patients with mandibular canal discontinuity, 9 (64.28%) exhibited paresthesia. In patients where mandibular canal continuity was maintained, 5 (8.62%) patients reported paresthesia. These results suggest a higher incidence of paresthesia in patients with mandibular canal discontinuity, albeit with a small sample size. Notably, only 3 patients in the discontinuity group did not show any sign of improvement, while the remaining patients in both groups demonstrated complete recovery in 6 months of follow-up period.

Discussion:
The findings suggest a potential link between mandibular canal discontinuity and an increased risk of paresthesia in postoperative mandibular fracture patients. It is hypothesized that discontinuity may lead to nerve compression, irritation, or direct damage during healing. The observed complete recovery in most patients, including those with paresthesia, highlights the potential for the nervous system to repair itself over a period of time. However, further studies with larger sample sizes are warranted to establish a more definitive correlation.

Conclusion:
This study provides preliminary evidence that mandibular canal discontinuity may contribute to a higher incidence of paresthesia in postoperative mandibular fracture patients. Clinicians should be cautious when addressing mandibular fractures to minimize the risk of nerve damage, particularly in cases involving canal discontinuity. The encouraging trend of complete recovery among the majority of patients suggests a positive prognosis for nerve healing.
Transconjunctival Levator Aponeurosis-Müller Muscle Complex Plication to Correct the Acquired Ptosis Following Double-Eyelid Surgery
Authors: Jeong Yeonwoo , Yoo Hyokyung , The Tran Vinh Vuong , Hong Ki Yong , Kim Sukwha 
Published: May 2024

One of the most common adverse outcomes of an upper blepharoplasty involving double-eyelid surgery is asymmetric upper eyelids due to unbalanced supratarsal folds or a difference in the palpebral fissure height. This study aimed to evaluate the efficacy and safety of transconjunctival levator aponeurosis-Müller muscle complex plication for correcting acquired ptosis following double-eyelid surgery. This retrospective study evaluated 18 patients who underwent transconjunctival levator aponeurosis-Müller muscle complex plication between June 2016 and June 2019 to correct acquired ptosis. On the basis of the main area of eyelid drooping, ptosis was categorized as central (mid-pupillary), medial (medial limbus), or lateral (lateral limbus). Preoperative and postoperative palpebral fissure heights were measured and compared. Three months postsurgery, the mean difference in palpebral fissure height between bilateral eyes decreased from 0.96 to 0.04 mm in the medial (P<0.001), from 0.93 to 0.00 mm in central (P=0.003), and from 1.30 to −0.03 mm in lateral ptosis (P=0.079). In 13 patients who underwent unilateral correction, the amount of plication was significantly associated with increased palpebral fissure height at the medial limbus (P=0.043) and mid-pupillary line (P=0.035). All patients reported a significant improvement in satisfaction. Five patients experienced acute postoperative complications, including chemosis, conjunctival injection, and foreign body sensation, all of which were resolved after a month of observation. No asymmetries or recurrences were observed. Transconjunctival levator aponeurosis-Müller muscle complex plication is a minimally invasive, safe, and effective technique for correcting acquired ptosis following upper eyelid surgery.
Combined Genioplasty and External Oblique Line Grafting: An Innovative Method to Improve Lower Facial Contour
Authors: Zang Tianying , Tang Xiaojun , Yin Lin 
Published: May 2024

Background:
Microgenia and the accompanying plump cheeks or hamster-like facial contour are all unattractive appearances among the Asian. Genioplasty with autogenous bone grafting is one of the effective ways to improve microgenia, in which a suitable donor area with less additional damage, lower infection rate, and more excellent effect is crucial.

Methods:
Patients who had undergone genioplasty and autogenous external oblique line grafting (G-EOL) were followed up. The operation-related complications, preoperative, and long-term follow-up 3-dimensional spiral computed tomography (3D-CT) were collected and analyzed.

Results:
Eight female patients who had received G-EOL and received 1 to 3 years of follow-up were included in this study. There were no short-term or long-term complications. CT data of bone of 8 patients and CT data of soft tissue of 6 patients at the preoperative and long term were compared. Through comparing CT data, the width at the level of the intersection of EOL and mandibular body, and the protrusion of the bony chin had improved significantly; the P values were all <0.001. Through measuring the soft tissue and analyzing the data, the ratio of lower and middle facial width, and the distance from the lower lip to Ricketts’ line were all improved, with the P values 0.042 and 0.001, respectively.

Conclusions:
For patients with microgenia and hamster-like facial contour, the combination of genioplasty and autogenous external oblique line grafting is innovative and effective in improving both the front and side contour of the lower face simultaneously, with excellent stability, bone healing, and low complication rates.