bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circadian-driven tissue specificity is constrained under caloric restricted feeding conditions
Authors: Chen Renrui , Zhang Ziang , Ma Junjie , Liu Bing , Huang Zhengyun , Hu Ganlu , Huang Ju , Xu Ying , Wang Guang-Zhong 
Published: June 2024

AbstractTissue specificity is a fundamental property of an organ that affects numerous biological processes, including aging and longevity, and is regulated by the circadian clock. However, the distinction between circadian-affected tissue specificity and other tissue specificities remains poorly understood. Here, using multi-omics data on circadian rhythms in mice, we discovered that approximately 35% of tissue-specific genes are directly affected by circadian regulation. These circadian-affected tissue-specific genes have higher expression levels and are associated with metabolism in hepatocytes. They also exhibit specific features in long-reads sequencing data. Notably, these genes are associated with aging and longevity at both the gene level and at the network module level. The expression of these genes oscillates in response to caloric restricted feeding regimens, which have been demonstrated to promote longevity. In addition, aging and longevity genes are disrupted in various circadian disorders. Our study indicates that the modulation of circadian-affected tissue specificity is essential for understanding the circadian mechanisms that regulate aging and longevity at the genomic level.
Speech prosody enhances the neural processing of syntax
Authors: Degano Giulio , Donhauser Peter W. , Gwilliams Laura , Merlo Paola , Golestani Narly 
Published: June 2024

AbstractHuman language relies on the correct processing of syntactic information, as it is essential for successful communication between speakers. As an abstract level of language, syntax has often been studied separately from the physical form of the speech signal, thus often masking the interactions that can promote better syntactic processing in the human brain. However, behavioral and neural evidence from adults suggests the idea that prosody and syntax interact, and studies in infants support the notion that prosody assists language learning. Here we analyze a MEG dataset to investigate how acoustic cues, specifically prosody, interact with syntactic representations in the brains of native English speakers. More specifically, to examine whether prosody enhances the cortical encoding of syntactic representations, we decode syntactic phrase boundaries directly from brain activity, and evaluate possible modulations of this decoding by the prosodic boundaries. Our findings demonstrate that the presence of prosodic boundaries improves the neural representation of phrase boundaries, indicating the facilitative role of prosodic cues in processing abstract linguistic features. This work has implications for interactive models of how the brain processes different linguistic features. Future research is needed to establish the neural underpinnings of prosody-syntax interactions in languages with different typological characteristics.
Protein arginine methyltransferase 2 controls inflammatory signaling in acute myeloid leukemia
Authors: Sauter Camille , Morin Thomas , Guidez Fabien , Simonet John , Fournier Cyril , Row Céline , Masnikov Denis , Pernon Baptiste , Largeot Anne , Aznague Aziza , Hérault Yann , Sauvageau Guy , Maynadié Marc , Callanan Mary , Bastie Jean-Noël , Aucagne Romain , Delva Laurent 
Published: June 2024

AbstractArginine methylation is catalyzed by protein arginine methyltransferases (PRMTs) and is involved in various cellular processes, including cancer development. PRMT2 expression is increased in several cancer types although its role in acute myeloid leukemia (AML) remains unknown. Here, we investigate the role of PRMT2 in a cohort of patients with AML, PRMT2 knockout AML cell lines as well as a Prmt2 knockout mouse model. In patients, low PRMT2 expressors are enriched for inflammatory signatures, including the NF-κB pathway, and show inferior survival. In keeping with a role for PRMT2 in control of inflammatory signaling, bone marrow-derived macrophages from Prmt2 KO mice display increased pro-inflammatory cytokine signaling upon LPS treatment. In PRMT2-depleted AML cell lines, aberrant inflammatory signaling has been linked to overproduction of IL6, resulting from a deregulation of the NF-κB signaling pathway, therefore leading to hyperactivation of STAT3. Together, these findings identify PRMT2 as a key regulator of inflammation in AML.
Patterns of synchronized clusters in adaptive networks
Authors: Lodi Matteo , Panahi Shirin , Sorrentino Francesco , Torcini Alessandro , Storace Marco 
Published: June 2024

AbstractAdaptive networks with time-varying connectivity, often called plasticity, provide a fundamental paradigm to model complex dynamical systems. In these systems, different groups of elements frequently exhibit different yet synchronized dynamics within each group. Here we propose a framework to study patterns of synchronous solutions in a large class of plastic networks and derive a general approach to analyze the stability of these solutions. This approach decouples the role of the network topology from that of the dynamic, thus leading to a dimensionality reduction of the stability problem and allowing us to investigate how adaptation affects the emergence of multi-stable patterns of synchronized activity. To illustrate its potentialities, we apply our method to three networks of oscillators, with distinct topology, dynamics, and adaptation rules. Our working framework encompasses a large class of heterogeneous multi-layer dynamical networks, connected (even with delays) via different plastic links, and can have a broad impact on the analysis of complex plastic networks.
Efficient electrochemical reduction of nitrate to ammonia over metal-organic framework single-atom catalysts
Authors: Shan Lutong , Ma Yujie , Xu Shaojun , Zhou Meng , He Meng , Sheveleva Alena M. , Cai Rongsheng , Lee Daniel , Cheng Yongqiang , Tang Boya , Han Bing , Chen Yinlin , An Lan , Zhou Tianze , Wilding Martin , Eggeman Alexander S. , Tuna Floriana , McInnes Eric J. L. , Day Sarah J. , Thompson Stephen P. , Haigh Sarah J. , Kang Xinchen , Han Buxing , Schröder Martin , Yang Sihai 
Published: June 2024

AbstractThe design and preparation of efficient catalysts for ammonia production under mild conditions is a desirable but highly challenging target. Here, we report a series of single-atom catalysts [M-SACs, M = Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Mo(II)] derived from UiO-66 containing structural defects and their application to electrochemical reduction of nitrate (NO3-) to ammonia (NH3). Cu-SAC and Fe-SAC exhibit remarkable yield rates for NH3 production of 30.0 and 29.0 mg h−1 cm−2, respectively, with a high Faradaic efficiency (FENH3) of over 96% at −1.0 V versus the reversible hydrogen electrode. Importantly, their catalytic performance can be retained in various simulated wastewaters. Complementary experiments confirmed the nature of single-atom sites within these catalysts and the binding domains of NO3- in UiO-66-Cu. In situ spectroscopic techniques, coupled with density functional theory calculations confirm the strong binding of NO3- and the formation of reaction intermediates, thus facilitating the catalytic conversion to NH3.
Cryptic geological histories accessed through entombed and matrix geochronometers in dykes
Authors: Kirkland Christopher L. , Dröllner Maximilian , Quentin de Gromard Raphael , Ribeiro Bruno V. , Olierook Hugo K. H. , Hartnady Michael , Barham Milo , Liebmann Janne , Smithies Hugh , Zametzer Andreas 
Published: June 2024

AbstractDeep geology of ancient continental crust can be difficult to access, with direct observation restricted to limited exposures. The age and composition of hidden geology can be gleaned from indirect isotopic modelling or via detrital minerals within overlying basins. Here we present an alternative, where direct grain sampling of ancient components within the South West Terrane, Yilgarn Craton, by a Proterozoic dyke evidences deep intact, or detritus from, Paleoarchean crust. U–Pb geochronology on this dyke reveals c. 3440 Ma zircon inclusions within titanite. This zircon was protected from overprinting fluids that obliterated unshielded crystals. Similar ancient zircon is present within recent sediment from the Swan-Avon river, which drains the terrane. The most parsimonious interpretation is that the dyke is 1390 Ma. Sequential overprinting is also recorded, with titanite preserving primary crystallization and c. 1000 Ma Pinjarra Orogeny-related overprinting. In contrast, apatite preserves c. 210 Ma ages, correlated with denudation of sedimentary cover.
Hot rings on Io observed by Juno/JIRAM
Authors: Mura Alessandro , Tosi Federico , Zambon Francesca , Lopes Rosaly M. C. , Mouginis-Mark Peter J. , Becker Heidi , Filacchione Gianrico , Migliorini Alessandra , Hansen Candice. J. , Adriani Alberto , Altieri Francesca , Bolton Scott , Cicchetti Andrea , Di Mico Elisa , Grassi Davide , Noschese Raffaella , Moirano Alessandro , Pettine Madeline , Piccioni Giuseppe , Plainaki Christina , Rathbun Julie , Sordini Roberto , Sindoni Giuseppe 
Published: June 2024

AbstractIt has been thought that Io’s many paterae may contain lava lakes, but observations by NASA’s Galileo spacecraft at sufficiently high resolution were limited to a few locations, such as Loki Patera. Data acquired by NASA’s Juno mission in May 2023 reveal a common set of thermal characteristics for at least ten paterae on Io, with bright (hot) “thermal rings” around the perimeter of their floors. Loki, Surt, Fuchi, Amaterasu, Mulungu, Chors, and Dazhbog Patera, and four unnamed paterae, all show the same pattern of surface temperature. This new Juno/JIRAM data suggests that hot rings around paterae are a common phenomenon, and that they are indicative of active lava lakes. All the investigated paterae lack recent lava flows on their flanks, suggesting that at the time of observations, the level of the lake was not high enough to overflow the rim. These observations provide insight about the characteristics of paterae’s activity, which may involve either central upwelling of magma, or up-and-down “piston-like” vertical motion of the lake surface. Tidal forces, which are extreme at Io, could play a role as well. Future observations from Juno, particularly during the closest flybys, may indicate which mechanism is more plausible.
Extraordinary 2021 snowstorm in Spain reveals critical threshold response to anthropogenic climate change
Authors: Insua-Costa Damián , Lemus-Cánovas Marc , González-Alemán Juan J. , Senande-Rivera Martín , Llasat María del Carmen , Miguez-Macho Gonzalo , Miralles Diego G. 
Published: June 2024

AbstractAttribution of extreme weather events to anthropogenic climate change (ACC) has become an increasingly important line of research in recent years. However, the potential influence of ACC on heavy snowstorms remains largely unexplored. Here we focus on studying the exceptional January 2021 snowfall event in Spain, known as Filomena. First, using observational data and flow analogs, we show that the characteristic synoptic pattern leading to the episode has not significantly changed in frequency over the past decades. Based on this, we assume a fixed dynamical pattern and focus on studying the influence of ACC on the thermodynamics of the event using an atmospheric model and a storyline attribution approach. Our simulations indicate that in northern highlands, ACC intensified snowfall by up to +40% compared with pre-industrial conditions, while in nearby southern lowlands ACC weakened snowfall by up to –80%. This characteristic shift from weakening to intensification is well defined by a critical threshold in temperature. Furthermore, we show that if Filomena were to occur at the end of the 21stcentury, this contrasting response to ACC would be enhanced. Altogether, our findings highlight the large but uneven impact of global warming on extreme snowstorm events.
Identifying Components of a Person-Centered Augmentative and Alternative Communication Intervention for People With Dementia: Opinions of an International Expert Panel
Authors: May Adele A. , Dada Shakila , Murray Janice 
Published: June 2024

Purpose:
Despite general agreement on the importance of person-centered care in speech-language pathology, guidelines for developing person-centered interventions for those with dementia are limited. This study aimed to obtain expert opinion on the components of a person-centered augmentative and alternative communication (AAC) intervention for persons with dementia.

Method:
A modified electronic Delphi technique was employed in a single round. A purposively sampled panel of experts was invited to provide their opinion on three open-ended questions related to (a) the elements of person-centered care, (b) communication supports, and (c) the interaction outcomes of a person-centered intervention. Thirty-one experts from nine countries participated on the panel. The majority were speech-language pathologists primarily involved in research. Qualitative written data were coded and analyzed using content analysis.

Results:
Nine components were identified across the three open-ended questions: (a) the unique characteristics of the person with dementia, (b) working with a person with dementia, (c) preserving personhood, (d) a different view on person-centered care, (e) a range of communication supports, (f) supportive conversational partners, (g) designing communication supports, (h) interaction outcome measure, and (i) meaningful interaction outcomes.

Conclusion:
This study identified nine components that are useful in guiding speech-language pathologists in crafting future person-centered AAC interventions for people with dementia.
Design of a high‐frequency transformer based on amorphous cut cores for insulation breakdown testing
Authors: Lagerweij Gijs , Niasar Mohamad Ghaffarian 
Published: June 2024

AbstractInnovative test methods are required to keep up with the increased demand for insulation materials which can withstand the high‐frequency square‐wave voltages generated by power‐electronic equipment. Test systems using high‐voltage, high‐frequency transformers have proven versatile and easy to realise. The authors investigate the application of amorphous cut cores in such transformers. Analytical and numerical models for the transformer and its frequency response are developed, aiding the design process. An amorphous core‐based transformer is designed for 8 kVpk output at 100 kHz and compared to two previous designs based on ferrite cores. The frequency and pulse response, as well as the high‐voltage and thermal performance, are evaluated. The comparison shows that while the low parasitics of the amorphous‐based transformer allow for superior frequency response, they are unsuitable for long‐duration tests with high pulse repetition frequencies (25–100 kHz) due to increased core losses. The partial discharge inception and flashover voltage are comparable to the ferrite‐based transformers.
Self‐supervised binocular depth estimation algorithm with self‐rectification for autonomous driving
Authors: Bao Jingyao , Yu Hongfei , Zou Yongjia , Lv Jin , Liu Wei , Cao Yang 
Published: June 2024

AbstractAiming to address the challenge where existing methods struggle to predict accurate disparities for imperfectly rectified stereo images, and that supervised training requires a considerable amount of ground truth, a self‐supervised binocular depth estimation algorithm with self‐rectification for autonomous driving is proposed. Firstly, a subnetwork dedicated to stereo rectification, aiming to estimate the homography between stereo images is developed. This homography facilitates the transformation of stereo image pairs, aligning their corresponding pixels horizontally. Secondly, a foundational self‐supervised framework primarily centred on minimizing errors in stereo image reconstruction, combined with the generative‐adversarial strategy is introduced. Finally, a vertical offset prediction module (VOPM) is incorporated into the basic framework to further enhance the resistance of the stereo matching network to pixel‐level vertical offset errors. Experimental results on the public KITTI dataset for autonomous driving demonstrate the effectiveness of this approach in improving the disparity prediction performance for imperfectly rectified stereo images. Moreover, the self‐supervised training framework exhibits superiority over state‐of‐the‐art methods.
Implementation of unknown parameter estimation procedure for hybrid and discrete non‐linear systems
Authors: Razm‐Pa Mahdi 
Published: June 2024

AbstractThe application of the hybrid extended Kalman filter (HEKF), hybrid unscented Kalman filter (HUKF), hybrid particle filter (HPF), and hybrid extended Kalman particle filter (HEKPF) is discussed for hybrid non‐linear filter problems, when prediction equations are continuous‐time and the update equations are discrete‐time, and also the discrete extended Kalman filter (DEKF), discrete unscented Kalman filter (DUKF), discrete particle filter (DPF), and discrete extended Kalman particle filter (DEKPF) for discrete‐time non‐linear filter problems, when prediction equations and update equations are discrete‐time. In order to assess the performance of the filters, the authors consider the non‐linear dynamics for a re‐entry vehicle. The filters are used in two hybrid and discrete states to estimate the position, velocity, and drag parameter associated with the re‐entry vehicle. Theoretical topics concerning estimating the drag parameter of a vehicle in re‐entry phase have been dealt with. Drag parameter estimation is carried out using a combination of hybrid filters and discrete filters as an effective estimator and fixed value, forgetting factor, and Robbins‐Monro stochastic approximation methods as the noise covariance matrix adjuster of the parameter.
Early Hyperprogression of Rhabdomyosarcoma Detected by 18F-FDG PET/CT Three Weeks after CAR-T Treatment
Authors: Guo Shenrui , Tan Zhen , Guan Wenbin , Yin Yafu 
Published: June 2024

AbstractChimeric antigen receptor T-cell (CAR-T) treatment has been widely used in the treatment of hematological malignancies, and its application has been gradually expanded to the research and treatment of solid tumors. However, unconventional types of response may occur after CAR-T treatment, such as hyperprogression, resulting in terrible outcomes. Here, we report the case of a 13-year-old adolescent boy with relapsed and refractory rhabdomyosarcoma who developed early hyperprogression 3 weeks after CAR-T treatment (target: B7H3 and CD171), which was detected by fluorine-18 fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT). The patient eventually underwent amputation. Attention should be paid to the possibility of early hyperprogression after CAR-T treatment, and 18F-FDG PET/CT has an absolute advantage in early evaluating treatment response to immunotherapy.
Detection of Spondyloepiphyseal Dysplasia Phenotype with CHST3 Mutation in an Asian Indian Family and Outcomes of Index and Subsequent Pregnancy
Authors: Gupta Sonal Omprakash , Gupta Omprakash Premnarayan , Jaipuria Nirmala Kisanlal , Turkar Ghanshyam M. , Chaurasiya Sachin , Kapse Shivanjali 
Published: June 2024

Abstract
CHST3-related skeletal dysplasia is an autosomal recessive disorder with a prenatal onset. Variations in the CHST3 gene are associated with spondyloepiphyseal dysplasia with short stature of prenatal onset; dislocation of the knees, hips or elbows; club feet; postnatal limitation of range of motion of large joints; and progressive kyphosis, occasional scoliosis and minor heart valve dysplasia. The identification of pathogenic variants in the family is helpful for carrier and prenatal testing. We describe the prenatal identification of spondyloepiphyseal dysplasia with CHST3 mutation in the index pregnancy of an Asian Indian woman and the outcome of the subsequent pregnancy.
Effect of Internet Addiction on Sleep Quality and Academic Performance in Undergraduate Dental Students
Authors: Rana Avni , Mathur Anmol , Kharia Ayush , Mathur Aditi 
Published: June 2024

Abstract
Aim This study aimed to evaluate the prevalence of Internet addiction and its effect on sleep patterns and university academic performance among dental undergraduates.
Methodology A total of 400 dental undergraduates were targeted in a cross-sectional setting. The students were invited to fill out a pretested questionnaire consisting of the Pittsburgh Sleep Quality Index (PSQI) and the Internet Addiction Test. Data was analyzed using the Statistical Package for Social Science (SPSS) software (version 20.0). Frequencies and percentages along with mean and standard deviation were calculated.
Results A total of 274 study subjects participated in the study out of which the majority of respondents were females (N = 230; 83.9%). Seventy-six percent of the population was using the Internet for 0 to 6 hours. Excellent academic performance scores have not been reported in any of the years except the second year. The mean global PSQI score and Internet addiction score both are seen to be reducing as the year of study increases. Internet addiction is positively associated with poor PSQI scores.
Conclusion The authors concluded that adequate sleep is undoubtedly the most important factor. Internet usage is a dynamic issue; the students need to manage it in a strict schedule to manage a decent total sleeping time.
Conventional Adenoidectomy versus Endoscope-Assisted Adenoidectomy: Comparative Study
Authors: Raj Amitha , Saldanha Marina , Kalam Ahsain S. , Aroor Rajeshwari , Kamath Shrinath D. 
Published: June 2024

Abstract
Objectives Adenoidectomy is a common surgical procedure in otorhinolaryngological practice.Conventionally, adenoidectomy is performed with a curette. The present study aims to compare the conventional method with the newer endoscope-assisted adenoidectomy method.
Materials and Methods This prospective study was done in 36 patients requiring adenoidectomy at a tertiary care center from January 2020 to June 2021. The participants were allocated into two groups: group A (18) who underwent conventional adenoidectomy by curettage method and group B (18) who underwent endoscope-assisted microdebrider adenoidectomy. Data on indications for adenoidectomy, average surgical intraoperative time, and intraoperative blood loss were collected and compared between the groups. Postadenoidectomy symptom-based feedback was taken after 1 year. The intraoperative parameters were analyzed using mean ± standard deviation and independent t-test.
Results The average operative timing in the conventional adenoidectomy group was 13.89 ± 4.837 minutes as compared with 19.44 ± 4.706 minutes in the endoscope-assisted adenoidectomy group (p = 0.001). The average amount of blood loss in the conventional group was 21.528 ± 2.51 mL whereas in the endoscope assisted group it was 24.889 ± 4.45 mL (p = 0.009). None of the patients had any symptoms suggestive of recurrence on 1-year follow-up.
Conclusion Conventional adenoidectomy and endoscope-assisted adenoidectomy are safe and effective methods for adenoidectomy. Endoscopic adenoidectomy has the additional advantage of surgical removal under visualization. Depending on the clinical setup and with adequate training both procedures are effective.