bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute and Late Outcomes of Transcatheter Aortic Valve Implantation (TAVI) for the Treatment of Severe Symptomatic Aortic Stenosis in Patients at High‐ and Low‐Surgical Risk
Authors: SCHYMIK GERHARD , SCHRÖFEL HOLGER , SCHYMIK JAN S. , WONDRASCHEK RAINER , SÜSELBECK TIM , KIEFER RÜDIGER , BALTHASAR VERONIKA , LUIK ARMIN , POSIVAL HERBERT , SCHMITT CLAUS 
Published: May 2012

Background:

This prospective study examines the impact of EuroSCORE and transfemoral (TF) or transapical (TA) delivery approach on mortality at 30 days and 1 year in patients with severe aortic stenosis implanted with either the Edwards SAPIEN Transcatheter Heart Valve (THV) or Medtronic CoreValve.
Methods and Results:

TAVI was successfully performed in 293 (97.7%) of 300 patients (TF: 174, TA: 126, mean EuroSCORE 24.0). The mortality at 30 days and after 1 year was 6.0% and 17.3%. Mortality depends significantly on the logistic EuroSCORE with a 30‐day odds ratio (OR) of 1.92 (95% CI 1.41 to 2.62, P < 0.001) and after 1 year of 1.67 (95% CI 1.34 to 2.08, P < 0.001). Mortality in patients with a logistic EuroSCORE <15 (n = 113) or ≥15 (n = 187) at 30 days was 0.9% versus 9.1% and after 1 year 7.1% versus 23.5% demonstrating significantly less mortality (P < 0.001) in patients with lower logistic EuroSCOREs. In this specific setup of our center there was no significant difference (P = 0.553) in mortality regarding the technical approach for TA (4.0% and 15.9%) and for TF (7.5% and 18.4%). Severe cardiac complications occurred in 20 patients (6.7%) with a 30‐day mortality of 45.0%.
Conclusion:

The mortality in patients undergoing TAVI correlates significantly with the logistic EuroSCORE. Patients with a logistic EuroSCORE <15 can be implanted, with a low 30‐day mortality and good long‐term outcome over 1 year. (J Interven Cardiol 2012;25:364–374)
Effect of air polishing with glycine powder on titanium abutment surfaces
Authors: Cochis Andrea , Fini Milena , Carrassi Antonio , Migliario Mario , Visai Livia , Rimondini Lia 
Published: May 2012

AbstractObjectiveThe aim of the present study was to evaluate morphological changes induced by glycine powder air polishing on titanium surfaces and its effect on bacteria recolonization in comparison with sodium bicarbonate powder.Materials and methods5 mm wide and 1 mm thick titanium grade II disks were divided into three groups of treatments: (i) no treatment; (ii) air polishing with glycine powder; (iii) air polishing with sodium bicarbonate powder. Specimens were characterized by laser profilometry, scanning electron microscopy (SEM) and then installed onto removable appliances worn for 24 h by healthy volunteers. Surface contamination was evaluated using SEM and counting the number of colony forming units (CFU).ResultsSEM observation revealed an increased roughness with the formation of craters on samples treated with sodium bicarbonate powder, while not in glycine ones. Statistical analysis failed to show significant differences of both Ra and Rmax parameters in treated groups. SEM observation of specimens surfaces, after 24 h of permanence in the oral cavity, showed a higher contamination of the disks treated with sodium bicarbonate compared with those not treated (P < 0.05). Conversely, the group treated with glycine showed the lower contamination if compared with bicarbonate‐treated group (P < 0.05).ConclusionsAir polishing with glycine powder may be considered as a better method to remove plaque from dental implant because glycine is less aggressive than sodium bicarbonate powder. Moreover, the use of glycine powder seems to have an active role on the inhibition of bacterial recolonization of implants in a short test period (24 h). Further studies are needed to demonstrate the bacteriostatic properties of glycine, envisaged on the basis of reduced contamination of the disks polished with glycine compared with those not treated.
Eighteenth‐Century Verse Miscellanies
Authors: Batt Jennifer 
Published: May 2012

AbstractThousands of verse collections containing the works of multiple authors were published in the 18th century. This essay offers a guide to recent scholarship on these collections of ‘poems by several hands’. It provides an overview of the many different kinds of miscellany and anthology that were produced, before exploring what these publications might reveal about the 18th‐century literary landscape. It considers what miscellanies and anthologies contribute to our understanding of authorship and anonymity, genre, canon formation and the literary past, women writers, and regionalism and nationalism. It then investigates what these texts reveal about 18th‐century reading practices, and about the workings of the 18th‐century book trade. The essay concludes with an account of an important current research project, the Digital Miscellanies Index.
Dispersal, philopatry, and the role of fission‐fusion dynamics in bottlenose dolphins
Authors: Tsai Yi‐Jiun Jean , Mann Janet 
Published: May 2012

AbstractIn this quantitative study of locational and social dispersal at the individual level, we show that bottlenose dolphins (Tursiops sp.) continued to use their natal home ranges well into adulthood. Despite substantial home range overlap, mother–offspring associations decreased after weaning, particularly for sons. These data provide strong evidence for bisexual locational philopatry and mother–son avoidance in bottlenose dolphins. While bisexual locational philopatry offers the benefits of familiar social networks and foraging habitats, the costs of philopatry may be mitigated by reduced mother–offspring association, in which the risk of mother–daughter resource competition and mother–son mating is reduced. Our study highlights the advantages of high fission–fusion dynamics and longitudinal studies, and emphasizes the need for clarity when describing dispersal in this and other species.
Digital photography as source documentation of skin toxicity: An analysis from the Trans Tasman Radiation Oncology Group (TROG) 04.01 Post‐Mastectomy Radiation Skin Care Trial
Authors: Graham Peter H , Plant Natalie A , Graham Jennifer Louise , Browne Lois H , Borg Martin , Capp Anne , Delaney Geoff P , Harvey Jennifer , Kenny Lizbeth , Francis Michael , Zissiadis Yvonne 
Published: May 2012

AbstractIntroduction: This study evaluated digital photographs as a method of providing auditable source documentation for radiotherapy‐induced skin toxicity and the possibility therefore of centralised, blinded scoring for a multicentre randomised controlled trial.Methods: Digital photograph sets from the first five patients from each of 12 participating centres were audited. Minimum camera specifications and photograph requirements were protocol specified. Three readers rated photographs for four key quality items. They also scored skin reactions according to National Cancer Institute Common Terminology Criteria (CTC) v3.0 acute skin score and also for the presence of any moist desquamation.Results: Five hundred fifty‐two images were available. Field of view was scored as inadequate in 1–10%, focus inadequate in 0.4–4%, lighting inadequate in 0.2–3% and dividing line marking inadequate for scoring of skin reactions within sectors in 18–23% of photographs by three readers. Reader pairwise inter‐observer agreement was 83–88% for CTC acute skin scores, but the kappa value ranged from 0.58 to 0.73. The percentage of image sectors not scored by readers due to difficulty in assessing was 1–10%. Moist desquamation was scored by clinicians in 8 (medial)–13% (lateral) of patients compared with 3–5% and 5–11% by readers.Conclusion: Photo reader inter‐observer agreement is only moderate. Photo readers tended to underscore the frequency of moist desquamation, but the trend by sector parallels the clinical scorers. Photographs are useful source documents for auditing and monitoring, but not a replacement for clinical scoring.
MRI in spinal cord decompression sickness
Authors: Hennedige Tiffany , Chow Weien , Ng Yew Yee , Chung‐Tsing Gregory C , Lim Tchoyoson CC , Kei Pin Lin 
Published: May 2012

AbstractIntroduction: Spinal cord decompression sickness (DCS) is a rare condition that can lead to spinal cord infarction. Despite the low incidence of diving‐related DCS, we have managed to collect the data and MRI findings of seven patients who have been diagnosed with and treated for DCS in our local hyperbaric facility. This study describes the clinical presentation, MRI spinal cord findings, treatment administered and outcome of these patients.Methods: The patient medical records, from 1997 to 2007, were retrospectively reviewed. All patients with a final diagnosis of DCS and who underwent examination were included. The images were independently reviewed by two radiologists who recorded the location and number of lesions within the spinal cord. The Frankel grading was used to assess the initial and clinical outcome response.Results: Patchy‐increased T2W changes affecting several levels at the same time were found. Contrary to the popular notion that venous infarction is the leading cause of DCS, most of our patients also demonstrated affliction of grey matter, which is typically seen in an arterial pattern of infarction. Initial involvement of multiple (>6) spinal cord levels was associated with a poor outcome. Patients who continued to have multiple neurological sequelae with less than 50% resolution of symptoms despite recompression treatment were also those who had onset of symptoms within 30 min of resurfacing.Conclusions: DCS is probably a combination of both arterial and venous infarction. Short latency to the onset of neurological symptoms and multilevel cord involvement may be associated with a poorer outcome.
Disseminated tumour cells in bone marrow of patients with uveal melanoma
Authors: Eide Nils , Hoifødt Hanne K. , Nesland Jahn M. , Faye Ragnar S. , Qvale Geir A. , Faber Rowan T. , Jebsen Peter , Kvalheim Gunnar , Fodstad Øystein 
Published: May 2012

Abstract.Purpose:  Approximately 50% of patients with uveal melanomas develop metastases. Thus, it is important to improve our understanding of how melanoma metastases develop.Methods:  As part of a uveal melanoma micrometastasis study, we compared the detection rates of immunomagnetically selected (IMS) tumour cells in bone marrow (BM) with positively stained tumour cells using immunocytochemistry (ICC). Bone marrow mononuclear cells were isolated. Immunocytochemistry cytospin preparations were immunocytochemically stained in parallel with two different melanoma antibodies, 9.2.27 and HMB45. Using IMS, melanoma cells were selected from BM mononuclear cell fractions using immunomagnetic beads coated with the 9.2.27 antibody and identified by light microscopy.Results:  In cytospin preparations from 226 patients, melanoma cells were detected in 24 (10.6%), 10 with 9.2.27 and 17 with the HMB45 antibody. In three cases, we found positive cells with both antibodies. Six of the 226 (2.6%) patients that stained positively with ICC died with metastatic disease, all also positive with IMS. Sixty‐six (29.2%) patients had positive BM samples with IMS at the first examination. Immunomagnetic selection (IMS) was positive in 36.8% of the 57 patients who later developed clinical metastases. Twenty‐one IMS‐positive patients and 31 IMS‐negative patients died of metastases, in total 52 of 226 patients (23.0%). The mortality rate of melanoma metastasis was 24% (6/24) after at least 4 ½ years in ICC‐positive patients compared to 38.5% (20/52) in IMS‐positive patients.Conclusion:  The presence of melanoma cells in BM of patients with uveal melanoma is documented in our study with IMS and ICC. Immunomagnetically selected is more sensitive than ICC in detecting tumour cells in BM. However, statistically, we did not find any prognostic impact of the presence of melanoma cells in BM.
Russell body gastritis presented as a colliding lesion with a gastric adenocarcinoma: A case report
Authors: Choi Jiwoon , Eun Lee Hee , Byeon Sun‐ju , Nam Kyung Han , Kim Min A , Kim Woo Ho 
Published: May 2012

ABSTRACTRussell body gastritis (RBG) is a rare gastric mucosal lesion comprising numerous Russell body‐containing plasma cells (Mott cells). Early gastric cancer was discovered during a routine health checkup of a 55‐year‐old man treated with esophagogastroduodenoscopy. Endoscopic submucosal dissection and a histological examination revealed well‐differentiated tubular adenocarcinoma and RBG. The two lesions were contiguous but not intermingled. Helicobacter pylori infection was also identified. Immunohistochemically, Mott cells of RBG manifested λ‐light chain restriction. However, polymerase chain reaction analysis did not reveal IgH gene rearrangement. Epstein–Barr virus encoded RNA in situ hybridization showed no Epstein–Barr virus infection in cancer or Mott cells. Thus, two distinct RBG features are demonstrated: coexistence with early gastric cancer and λ‐light chain restriction. The proliferation of Mott cells with light chain restriction may be due to a chronic hyperinflammatory response caused by H. pylori infection. However, it is unclear whether RBG is associated with gastric carcinoma.
Study of incidence and pattern of rare tumors of breast: Study in a tertiary care centre
Authors: Deepak Kumar B. , Vinaya Kumari C. M. 
Published: May 2012

ABSTRACTBackground and aim: Breast lesions, though more common than most other organ lesions, still deserve a special place in every pathologists mind because of their diversity. Lesions in the breast vary from simple fibroadenoma to various commoner carcinomas like infiltrating ductal carcinomas, to rarer entities, such as angiosarcoma, hemangiopericytoma, nodular hidradenoma, pleomorphic variant of lobular carcinoma, medullary carcinomas and carcinoid tumors; which can be compared to “an oasis in the desert”. Methods: A 3‐year retrospective study was carried out to evaluate the incidence and pattern of rare breast lesions in an upcoming teaching hospital, along with clinicohistopathological correlation. Specimens were preserved in 10% formalin and processed in a routine manner. Hematoxylin–eosin sections were studied and a morphological diagnosis was reached. Results: Some rare entities, namely pleomorphic variant of lobular carcinoma, medullary carcinoma, mucinous carcinoma, tubular carcinoma, apocrine carcinoma, cribriform carcinoma, anaplastic carcinoma, occult breast carcinoma, hemangiopericytoma, angiosarcoma, carcinoid tumor and nodular hidradenoma, were diagnosed. A brief review of published work of the various rare entities encountered in the present study was also made. Conclusions: It is imperative to be vigilant during microscopic diagnosis so that rare tumors are not missed.
Anti‐Tumor Effects and Pharmacokinetics of S‐40542, a Novel Non‐Steroidal Anti‐Androgen, in Mice
Authors: NEJISHIMA Hiroaki , YAMAMOTO Noriko , SUZUKI Mika , FURUYA Kazuyuki , MIMURA Mitsuo , YAMADA Shizuo 
Published: May 2012

Objectives: The current study was undertaken to explore novel anti‐androgens. We investigated a series of tetrahydroquinoline compounds and identified 1‐(8‐nitro‐3a,4,5,9b‐tetrahydro‐3H‐cyclopenta[c]quinolin‐4‐yl)ethane‐1,2‐diol (S‐40542).Methods: Affinity for androgen receptor of S‐40542 was evaluated in receptor binding assay. Effects of repeated treatment with S‐40542 and bicalutamide on prostate weight were examined in mice subcutaneously treated for 14days. Efficacy of S‐40542 and bicalutamide against prostate cancer was evaluated in an androgen‐dependent prostate cancer xenograft model using KUCaP‐2 cell line. Plasma concentrations of these agents in mice after oral and subcutaneous administration were measured by liquid chromatography‐tandem mass spectrometry (LC‐MS/MS) system.Results: S‐40542 displayed twofold higher affinity to androgen receptor than bicalutamide in vitro. Subcutaneous repeated administration of S‐40542 (10–100 mg/kg) significantly reduced the prostate weight. Oral repeated treatment with S‐40542 (30, 100 mg/kg) for 28 days significantly suppressed growth of KUCaP‐2 tumor. Similar administration of bicalutamide also exerted significantly anti‐tumor effect in the model. The serum prostate‐specific antigen level was little influenced by the S‐40542 treatment, while significantly decreased by bicalutamide. Oral treatment with S‐40542 resulted in a dose‐dependent elevation of the plasma concentration, and its Cmax and AUC were much lower than those of bicalutamide. The pharmacokinetic study showed that this agent had relatively short plasma half‐life and low oral bioavailability.Conclusion: S‐40542 as well as bicalutamide has shown as an anti‐androgen by reducing the prostate weight of mice. Repeated oral treatment with S‐40542 was shown to significantly suppress tumor growth in the KUCaP‐2 xenograft model.
Influence of phosphoric acid etching on microleakage of a self‐etch adhesive and a self‐adhering composite
Authors: Rengo C , Goracci C , Juloski J , Chieffi N , Giovannetti A , Vichi A , Ferrari M 
Published: May 2012

AbstractBackground:  The aim of this study was to evaluate the influence of preliminary phosphoric acid etching on the microleakage of a self‐adhering flowable composite and a self‐etch adhesive used in combination with the proprietary flowable composite.Methods:  Standard Class V cavities were prepared on the buccal side of 20 extracted sound human molars. Specimens were randomly divided into five groups: (1) Gel Etchant/Optibond FL/Premise Flowable; (2) Vertise Flow; (3) Optibond XTR/Premise Flowable; (4) Gel Etchant/Vertise Flow; and (5) Gel Etchant/Optibond XTR/Premise Flowable (Kerr). The interfacial sealing ability of the materials was evaluated by scoring the depth of silver nitrate penetration and through scanning electron microscopy observations. Differences in leakage at either the enamel or the dentine interface were evaluated for statistical significance (Kruskal–Wallis ANOVA, Mann–Whitney U test, p < 0.05).Results:  At the enamel interface, no significant differences were found among the materials. On dentine, Gel Etchant/Vertise Flow had the highest leakage scores and the difference was statistically significant (p < 0.05).Conclusions:  The early sealing ability of the self‐adhering flowable composite and the self‐etch adhesive in Class V restorations did not significantly benefit from selective enamel etching. Preliminary phosphoric acid etching of dentine negatively affected the quality of the seal when using the adhesive‐free flowable composite.
Root caries and diabetes: risk assessing to improve oral and systemic health outcomes
Authors: Garton BJ , Ford PJ 
Published: May 2012

AbstractThis report reviews the current understanding of the relationship between diabetes and root caries, and investigates the evidence for dental chairside testing of gingival crevicular blood (GCB) glucose levels to assess risk for type 2 diabetes mellitus. Diabetes is linked with the progression of periodontal disease and a greater number of exposed root surfaces at risk for root caries. The rapidly increasing prevalence of type 2 diabetes coupled with a general trend towards retention of teeth means that the number of patients with increased risk for root caries is expanding significantly. Many patients with diabetes or abnormal blood glucose levels are unaware of their condition or that they are at increased risk for oral disease. Systemic blood glucose concentrations are comparable to those found in GCB and therefore may be a useful adjunctive clinical aid in determining appropriate care for patients and providing timely referrals to general medical practitioners. Use of GCB testing within the dental clinic is described. It is proposed that future studies be undertaken to provide clinicians with improved risk assessment strategies and to evaluate GCB glucose screening models.
Intestinal permeability and complications in liver cirrhosis: A prospective cohort study
Authors: Benjamin Jaya , Singla Vikas , Arora Indu , Sood Seema , Joshi Yogendra Kumar 
Published: May 2012

Aim:  Increased intestinal permeability (IP) has been implicated as an important factor for bacterial translocation (BT), leading to bacteremia and endotoxemia, resulting in various septic complications, variceal bleeding (VB), hepatic encephalopathy (HE), hepatorenal syndrome (HRS) and death in patients with liver cirrhosis (LC). This study was planned to assess IP in patients with LC and follow them for the occurrence of complications.Methods:  Patients with Child B and C cirrhosis without a history of disease‐related complications were followed up for 6 months. IP was measured by lactulose and mannitol excretion ratio (LMR) in patients and 50 healthy controls (HC). Serum endotoxin levels were also assessed in 48 patients and 20 HC.Results:  Eighty patients (74 male), 41 (51.3%) Child B and 56 (70%) Child C, with a mean age of 40.7 ± 9.8 years were enrolled. IP was increased in 28 (35%) patients. LMR of patients was higher than HC (patients vs HC = 0.0238 [0.0010–1.557] vs 0.0166 [0.0018–0.720]; P = 0.007]. No significant difference was seen in the LMR of patients among various Child classes and etiologies. Serum endotoxin levels (GMU/mL) were higher in patients than HC (patients vs HC = 1.42 [0.68–2.13] vs 0.994 [0.067–1.382]; P = 0.001), but comparable between patients with abnormal and normal IP. At follow up, there was no significant difference in the incidence of complications like spontaneous bacterial peritonitis, HRS, VB, HE and death between patients with abnormal and normal IP.Conclusion:  IP was increased in 35% of patients with LC; however, it was not associated with a higher incidence of disease‐related complications.
Intensity‐Modulated and Image‐Guided Radiation Therapy for Treatment of Genitourinary Carcinomas in Dogs
Authors: Nolan M.W. , Kogan L. , Griffin L.R. , Custis J.T. , Harmon J.F. , Biller B.J. , LaRue S.M. 
Published: May 2012

BackgroundExternal beam radiation therapy can be used to treat pelvic tumors in dogs, but its utility is limited by lack of efficacy data and associated late complications.Hypothesis/ObjectivesThe objective of this study was to assess local tumor control, overall survival, and toxicosis after intensity‐modulated and image‐guided radiation therapy (IM/IGRT) for treatment of genitourinary carcinomas (CGUC) in dogs.Animals21 client‐owned dogs.MethodsA retrospective study was performed. Medical records of dogs for which there was intent to treat with a course of definitive‐intentIM/IGRTforCGUCbetween 2008 and 2011 were reviewed. Descriptive and actuarial statistics comprised the data analysis.ResultsPrimary tumors were located in the prostate (10), urinary bladder (9), or urethra (2). The total radiation dose ranged from 54–58 Gy, delivered in 20 daily fractions. Grade 1 and 2 acute gastrointestinal toxicoses developed in 33 and 5% of dogs, respectively. Grade 1 and 2 acute genitourinary and grade 1 acute integumentary toxicoses were documented in 5, 5, and 20% of dogs, respectively. Four dogs experienced late grade 3 gastrointestinal or genitourinary toxicosis. The subjective response rate was 60%. The median event‐free survival was 317 days; the overall median survival time was 654 days. Neither local tumor control nor overall survival was statistically dependent upon location of the primary tumor.Conclusions and Clinical ImportanceIM/IGRTis generally well‐tolerated and provides an effective option for locoregional control ofCGUC. As compared with previous reports in the veterinary literature, inclusion ofIM/IGRTin multimodal treatment protocols forCGUCcan result in superior survival times; controlled prospective evaluation is warranted.
Genome Sequence of Proteorhodopsin-Containing Sea Ice Bacterium Glaciecola punicea ACAM 611
T
Authors: Qin Qi-Long , Xie Bin-Bin , Shu Yan-Li , Rong Jin-Cheng , Zhao Dian-Li , Zhang Xi-Ying , Chen Xiu-Lan , Zhou Bai-Cheng , Zhang Yu-Zhong 
Published: May 2012

ABSTRACT

Here, we report the draft genome sequence of Antarctic sea ice bacterium
Glaciecola punicea
ACAM 611
T
, the type species of the genus
Glaciecola
. A blue-light-absorbing proteorhodopsin gene is present in the 3.08-Mb genome. This genome sequence can facilitate the study of the physiological metabolisms and ecological roles of sea ice bacteria.