bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Nucleophile‐ or Light‐Induced Synthesis of 3‐Substituted Phthalides from 2‐Formylarylketones.
Authors: Gerbino Dario C. , Augner Daniel , Slavov Nikolay , Schmalz Hans‐Guenther 
Published: August 2012

AbstractPhthalides bearing an aryl substituent are formed with slightly higher yields by the photochemical reaction.
ChemInform Abstract: Direct and Efficient Synthesis of Pyrrole‐3‐carbaldehydes by Vilsmeier—Haack Formylation of Pyrroles with Sterically Crowded Amides.
Authors: Ilyin Petr V. , Pankova Alena S. , Kuznetsov Mikhail A. 
Published: August 2012

AbstractThe regioselectivity concerning the formylation of various pyrroles with sterically crowded formamides is studied.
ChemInform Abstract: Access to Spirocyclic Oxindoles via N‐Heterocyclic Carbene‐Catalyzed Reactions of Enals and Oxindole‐Derived α,β‐Unsaturated Imines.
Authors: Jiang Kun , Tiwari Bhoopendra , Chi Yonggui Robin 
Published: August 2012

AbstractUnder conditions A), the title reaction affords bicyclic lactam structures with all carbon spiro centers.
ChemInform Abstract: The First Organocatalytic Asymmetric Synthesis of 3‐Substituted Isoindolinones.
Authors: More Vijaykumar , Rohlmann Renate , Garcia‐Mancheno Olga , Petronzi Carmen , Palombi Laura , De Rosa Antonio , Di Mola Antonia , Massa Antonio 
Published: August 2012

AbstractIsoindolines are obtained with moderate to good enantiomeric excesses from organocatalytic aldol‐cyclization‐rearrangement tandem reaction of malonates with 2‐cyanobenzaldehydes.
ChemInform Abstract: Lead Optimization of the N1 Substituent of a Novel Series of Indazole Arylsulfonamides as CCR4 Antagonists and Identification of a Candidate for Clinical Investigation.
Authors: Procopiou Panayiotis A. , Ford Alison J. , Graves Rebecca H. , Hall David A. , Hodgson Simon T. , Lacroix Yannick M. L. , Needham Deborah , Slack Robert J. 
Published: August 2012

AbstractCompound (Id) is identified for further development within a novel series of indazole sulfonamide chemokine receptor 4 (CCR4) antagonists.
ChemInform Abstract: A New and Efficient Method for the Preparation of 2,4,6,8‐Tetraazabicyclo[3.3.0]octane‐3,7‐diones (Glycolurils) Catalyzed by Keggin, Wells—Dawson, and Preyssler Heteropolyoxometalates, Effect of Structure on the Reactivity.
Authors: Tayebee Reza , Esmaeil Rezaei‐Seresht , Behrooz Maleki 
Published: August 2012

AbstractA new protocol for the synthesis of glycolurils is presented including verification of the catalytic activity of structurally different heteropolyoxometalates.
ChemInform Abstract: Synthesis of 3,5‐Disubstituted Isoxazoles via Cope‐Type Hydroamination of 1,3‐Dialkynes.
Authors: Wang Liangguang , Yu Xiaoqiang , Feng Xiujuan , Bao Ming 
Published: August 2012

AbstractThe one‐pot synthesis starting from alkynes (IX) provides comparable yields.
ChemInform Abstract: Efficient Propylphosphonic Anhydride (®T3P) Mediated Synthesis of Benzothiazoles, Benzoxazoles and Benzimidazoles.
Authors: Wen Xiaoan , El Bakali Jamal , Deprez‐Poulain Rebecca , Deprez Benoit 
Published: August 2012

AbstractA quick preparation of the title compounds is developed via T3P‐promoted reaction of appropriately ortho‐functionalized anilines with carboxylic acids under microwave conditions.
ChemInform Abstract: An Efficient Method for C8‐Prenylation of Flavonols and Flavanones.
Authors: Kawamura Tomoyuki , Hayashi Moemi , Mukai Rie , Terao Junji , Nemoto Hisao 
Published: August 2012

AbstractThe highly efficient synthesis of C8‐prenylated derivatives of quercetin and hesperetin is accomplished using a regioselective Claisen rearrangement of ethers such as (III) and (VII) as the key steps.
ChemInform Abstract: Graphite Oxide Mediated Oxidative Aromatization of 1,4‐Dihydropyridines into Pyridine Derivatives.
Authors: Mirza‐Aghayan Maryam , Boukherroub Rabah , Nemati Mohammad , Rahimifard Mahshid 
Published: August 2012

AbstractReadily available inexpensive graphite oxide is used as a mild and efficient reagent.
ChemInform Abstract: A Novel and Chemoselective Synthesis of Substituted 3,4‐Dihydroisoquinolin‐1(2H)‐ones from o‐Oxiranylmethylbenzonitrile Intermediates and TBAB/NaCN.
Authors: Chen Po‐Yuan , Chen Hsing‐Ming , Chiang Michael Y. , Wang You‐Feng , Li Sie‐Rong , Wang Tzu‐Pin , Wang Eng‐Chi 
Published: August 2012

AbstractThe oxiranyl compounds (I) are prepared from isovallin via 5 steps.
ChemInform Abstract: Multicomponent Synthesis and in vitro and in vivo Anticancer Activity of Novel Arylmethylene Bis‐isoxazolo[4,5‐b]pyridine‐N‐oxides (IV).
Authors: Rajanarendar E. , Raju S. , Reddy M. Nagi , Krishna S. Rama , Kiran L. Hari , Reddy A. Ram Narasimha , Reddy Y. Narasimha 
Published: August 2012

AbstractCompound (IVa), the most active compound, possesses remarkable anticancer activity.
ChemInform Abstract: Synthesis of Novel Precursors of Pfitzinger Reaction: A Facile One‐Pot Strategy to the Synthesis of Quinoline Carboxylic Acid Derivatives of Pyrazolo‐Carbazoles and Azacarbazoles.
Authors: Tyagi Ruchi , Singh Bhawani , Kishore D. 
Published: August 2012

AbstractJapp—Klingemann reaction gives a one‐pot approach to otherwise hardly accessible heteroaryl hydrazones (III) which undergo Fischer indolization to pyrazolo‐fused (aza)carbazoles (IV).
ChemInform Abstract: [4 + 2] Cycloadditions of 3‐Tetrazolyl‐1,2‐diaza‐1,3‐butadienes: Synthesis of 3‐Tetrazolyl‐1,4,5,6‐tetrahydropyridazines.
Authors: Lopes Susana M. M. , Brigas Amadeu F. , Palacios Francisco , Lemos Americo , Pinho e Melo Teresa M. V. D. 
Published: August 2012

AbstractA large variety of dienophiles, including electron‐rich and ‐deficient 2π components, undergo the title reaction of hydrazones (I) or (XVII) to give the desired pyridazines, and in some cases open‐chain hydrazone derivatives.
ChemInform Abstract: Synthesis of Novel 4H‐Pyrimido[1,6‐a]pyrimidines via a One‐Pot Three‐Component Condensation.
Authors: Xiang Jinbao , Li Hanghang , Yang Kai , Yi Lang , Xu Yongnan , Dang Qun , Bai Xu 
Published: August 2012

AbstractA TfOH‐catalyzed one‐pot three‐component condensation of 4‐aminopyrimidines, aldehydes, and β‐keto esters is developed to provide access to the title skeleton.
ChemInform Abstract: Synthesis of Condensed Tetrahydroimidazo[1,2‐a]quinazoline‐1,5‐dione Derivatives.
Authors: Iminov Rustam T. , Tverdokhlebov Anton V. , Tolmachev Andrey A. , Volovenko Yulian M. , Shishkina Svetlana V. , Shishkin Oleg V. 
Published: August 2012

AbstractA novel approach to condensed hydrogenated imidazoquinazolines (III) and (V) is presented.
ChemInform Abstract: Synthesis, Antioxidant and Antimicrobial Evaluation of Thiazolidinone, Azetidinone Encompassing Indolylthienopyrimidines.
Authors: Saundane Anand Raghunath , Yarlakatti Manjunatha , Walmik Prabhaker , Katkar Vijaykumar 
Published: August 2012

AbstractAmong the novel indolylthiazolidinyl‐ and indolylazetidinyl‐thienopyrimidines prepared, those bearing chloro substituents possess promising antioxidant and antibacterial activity.
ChemInform Abstract: Tandem Michael Addition—Fries Rearrangement of Sorbylanilides: A Convenient One‐Pot Synthesis of Novel Benzo[b]azocin‐6‐ones.
Authors: Anand Amit , Singh Pardeep , Mehra Vishu , Amandeep Amandeep , Kumar Vipan , Mahajan Mohinder P. 
Published: August 2012

AbstractThe approach to the title compounds uses an unprecedented TFA‐mediated tandem Michael addition—Fries rearrangement of sorbyl anilines (I) via a γ‐lactone intermediate.
ChemInform Abstract: Synthesis of Enantiopure 7‐Substituted Azepane‐2‐carboxylic Acids as Templates for Conformationally Constrained Peptidomimetics.
Authors: Cini Elena , Bifulco Giuseppe , Menchi Gloria , Rodriguez Manuela , Taddei Maurizio 
Published: August 2012

AbstractGlutamic acid γ‐aldehydes (III) obtained by a Horner—Wadsworth—Emmons reaction undergo a palladium‐catalyzed double‐bond hydrogenation/hydrogenolysis of the benzyl groups to provide the desired azepanes with good to excellent diastereomeric ratios.
ChemInform Abstract: Nicotinium Dichromate (= 3‐Carboxypyridinium Dichromate; NDC) as an Efficient Reagent for the Oxidative Deamination of Amines and Aminophosphonates.
Authors: Sobhani Sara , Aryanejad Sima , Maleki Mahdi Faal 
Published: August 2012

AbstractA new and efficient reagent for the facile preparation of various aldehydes, ketones and oxophosphonates is presented.
ChemInform Abstract: New Synthetic Methodology Leading to a Series of Novel Heterocyclic α‐Aminophosphonates: A Very Attractive Expansion of Kabachnik—Fields Reaction.
Authors: Qu Zhibo , Chen Xiaolan , Yuan Jinwei , Bai Yunliang , Chen Tong , Qu Lingbo , Wang Fujun , Li Xu , Zhao Yufen 
Published: August 2012

AbstractThe convenient one‐pot three‐component process excludes the use of aromatic amines.
ChemInform Abstract: Przewalskone: A Cytotoxic Adduct of a Danshenol Type Terpenoid and an Icetexane Diterpenoid via Hetero‐Diels—Alder Reaction from Salvia przewalskii.
Authors: Xu Gang , et al. et al. 
Published: August 2012

AbstractThe structure, absolute configuration, and significant cytotoxicities against 5 human cancer cell lines of the title compound are reported.
ChemInform Abstract: Stereocontrolled Synthesis of Functionalized Spirocyclic Compounds Based on Claisen Rearrangement and Its Application to the Synthesis of Spirocyclic Sesquiterpenes and Pyrrolidinoindoline Alkaloids
Authors: Nakazaki Atsuo , Kobayashi Susumu 
Published: August 2012

AbstractReview: ca. 100 refs.
ChemInform Abstract: Biological Applications of Magnetic Nanoparticles
Authors: Colombo Miriam , Carregal‐Romero Susana , Casula Maria F. , Gutierrez Lucia , Morales Maria P. , Boehm Ingrid B. , Heverhagen Johannes T. , Prosperi Davide , Parak Wolfgang J. 
Published: August 2012

AbstractReview: 423 refs.
Determining the impact of US mammography screening guidelines on patient survival in a predominantly African American population treated in a public hospital during 2008
Authors: Habtes Imnett , Friedman Danielle , Raskind‐Hood Cheryl , Adams Kathleen , Becker Edmund R. , D'Orsi Carl , Birdsong George , Gundry Kathleen , O'Regan Ruth , Gabram Sheryl G. A. 
Published: August 2012

AbstractBACKGROUND:In November 2009, the US Preventive Service Task Force (USPSTF) published updated breast cancer screening guidelines. This marked a change from the 2002 recommendations and a significant divergence from the American Cancer Society (ACS) guidelines. In the current study, the potential effect of using the revised 2009 USPSTF guidelines on patient disease stage and survival were evaluated and compared with those actually observed and to predicted under ACS recommendations.METHODS:A retrospective chart review was performed for 84 patients who were diagnosed with stage I through III breast cancer at Grady Memorial Hospital during 2008. Previously published tumor volume doubling times were used to model an equation that would estimate tumor sizes. For each patient, a disease stage at diagnosis was predicted, and outcomes were modeled as though the patient had been screened according to the recommended versions of the ACS and USPSTF guidelines. Patient survival rates were then estimated based on prognostic data according to disease stage.RESULTS:The average age of patients in the study was 55 years, and 85% were African American. The USPSTF guidelines predicted later stages at diagnosis (14% stage I, 73% stage II), whereas the ACS guidelines predicted earlier stages (47% stage I, 53% stage II).CONCLUSIONS:A large stage migration was predicted, indicating significantly earlier diagnosis, when the ACS‐recommended screening guidelines were followed. The authors concluded that practitioners should understand how race and/or socioeconomic factors increase the risk of breast cancer and should be encouraged to prioritize discussions regarding the benefits and risks of annual mammographic screening, especially among women who have a potentially greater risk of developing breast cancer at a younger age. Cancer 2013. © 2012 American Cancer Society.
Production of Biobutanediols by the Hydrogenolysis of Erythritol
Authors: Amada Yasushi , Watanabe Hideo , Hirai Yuichirou , Kajikawa Yasuteru , Nakagawa Yoshinao , Tomishige Keiichi 
Published: August 2012

AbstractThe hydrogenolysis of erythritol using an Ir–ReOx/SiO2 catalyst was performed for the production of butanediols, which are widely used as a raw material of polymers. The activity and selectivity to butanediols on Ir–ReOx/SiO2 was much higher than that on conventional hydrogenolysis catalysts. The maximum selectivity to 1,4‐ and 1,3‐butanediols reached 33 and 12 % at 74 % conversion, respectively. The erythritol conversion and selectivity to butanediols was almost maintained during four repeating tests if small amounts of acid were added to the reaction and the catalyst was calcined again. The reaction kinetics, reactivity trends, and characterization results indicate a direct hydrogenolysis mechanism in which the hydride species on the Ir metal surface attacks the alkoxide species on the 3D ReOx clusters. Based on the production of erythritol by the fermentation of glucose and glycerol, erythritol hydrogenolysis may be a promising pathway for the production of biobutanediols.
A high‐order curvature‐corrected CMOS bandgap voltage reference with constant current technique
Authors: Geng Junfeng , Zhao Yiqiang , Zhao Hongliang 
Published: August 2012

SUMMARYA high‐order curvature‐corrected complementary metal–oxide–semiconductor (CMOS) bandgap voltage reference (BGR), utilizing the temperature‐dependent resistor and constant current technique, is presented. Considering the process variation, a resistor trimming network is introduced in this work. The circuit is implemented in a standard 0.35‐µm CMOS process. The measurement results have confirmed that the proposed BGR operates with a supply voltage of 1.8 V, consuming 45 μW at room temperature (25 °C), and the temperature coefficient of the output voltage reference is about 5.5 ppm/°C from −40 °C to 125 °C. The measured power supply rejection ratio is −38.8 dB at 1 kHz. The BGR is compatible with low‐voltage and low‐power circuit design when the structure of operational amplifiers and all the devices in the proposed bandgap reference are properly designed. Copyright © 2012 John Wiley & Sons, Ltd.
Gate‐level body biasing technique for high‐speed sub‐threshold CMOS logic gates
Authors: Corsonello P. , Lanuzza M. , Perri S. 
Published: August 2012

An efficient technique for designing high‐performance logic circuits operating in sub‐threshold region is proposed. A simple gate‐level body biasing circuit is exploited to change dynamically the threshold voltage of transistors on the basis of the gate status. Such an auxiliary circuit prepares the logic gate for fast switching while maintaining energy efficiency.If 200 aJ is the target total energy per operation consumption, a two input NAND (NOR) gate designed as described here shows a delay reduction between 20% (16%) and 40% (48%), with respect to previously proposed sub‐threshold approaches. Copyright 2012 John Wiley & Sons, Ltd.
Bleaching response of Symbiodinium (zooxanthellae): Determination by flow cytometry
Authors: Lee Co Sin , Wilson Yeo Yin Sheng , Sin Tsai Min 
Published: August 2012

AbstractCoral bleaching is of increasing concern to reef management and stakeholders. Thus far, quantification of coral bleaching tends to be heavily reliant on the enumeration of zooxanthellae, with less emphasis on assessment of photosynthetic or physiological condition, these being often assessed separately by techniques such as liquid chromatography. Traditional methods of enumeration using microscopy are time consuming, subjected to low precision and great observer error. In this study, we presented a method for the distinction of physoiological condition and rapid enumeration of zooxanthellae using flow cytometry (FCM). Microscopy verified that healthy looking/live versus damaged/dead zooxanthellae could be reliably and objectively distinguished and counted by FCM on the basis of red and green fluorescence and light scatter. Excellent correlations were also determined between FCM and microscopy estimates of cell concentrations of fresh zooxanthellae isolates from Pocillopora damicornis. The relative intensities of chlorophyll and β‐carotene fluorescences were shown to be important in understanding the results of increased cell counts in freshly isolated zooxanthellae experimentally exposed to high temperatures (34, 36, and 38°C) over 24 h, with ambient temperature (29°C) used as controls. The ability to simultaneously identify and enumerate subpopulations of different physiological states in the same sample provides an enormous advantage in not just determining bleaching responses, but elucidating adaptive response and mechanisms for tolerance. Therefore, this approach might provide a rapid, convenient, and reproducible methodology for climate change studies and reef management programs. © 2012 International Society for Advancement of Cytometry
Evaluation of weight loss and adipocytokines levels after two hypocaloric diets with different macronutrient distribution in obese subjects with rs9939609 gene variant
Authors: de Luis Daniel Antonio , Aller Rocío , Izaola Olatz , de la Fuente Beatriz , Conde Rosa , Sagrado Manuel Gonzalez , Primo David 
Published: August 2012

AbstractBackgroundCommon polymorphisms of the fat mass and obesity associated gene (FTO) have been linked to obesity in some populations. One of these genetic variants (rs9939609) has been related to an increased risk of obesity.ObjectiveOur aim was to evaluate weight loss and adipocytokine levels after two hypocaloric diets with different macronutrient distribution in obese subjects with RS9939609 gene variant.Design305 obese patients were enrolled in a prospective way. In the basal visit, patients were randomly allocated during 3 months to low carbohydrates and low fat.ResultsAfter treatment with both diets and in both genotypes, weight, fat mass, waist circumference and systolic blood pressures decreased. With the diet type I and in TT genotype, insulin (−6.6 ± 9.8 IU/L) and homeostasis model assessment (−2.9 ± 6.1 units) decreased. With the diet type II and in both genotypes (wild and mutant type), insulin (−5.2 ± 6.1 vs. −3.8 ± 6.1 IU/L; p < 0.05) and homeostasis model assessment (−2.4 ± 4.8 vs. −1.1 ± 3.8 kg; p < 0.05) decreased. In the A allele group, a significant decrease was detected in total cholesterol levels (−11.5 ± 20.1 mg/dL), low density lipoprotein cholesterol levels (−13.2 ± 20.9 mg/dL) and c‐reactive protein levels (−1.3 ± 3.8 mg/dL) secondary to weight loss after treatment with diet II. The decrease of leptin levels was higher in mutant type group than wild type group with low fat diet (−10.3 ± 36.1 vs. −28.6 ± 53.7 ng/mL; p < 0.05).ConclusionMetabolic improvement secondary to weight loss was better in A carriers with a low fat hypocaloric diet. Copyright © 2012 John Wiley & Sons, Ltd.
New transgenic reporters identify somatosensory neuron subtypes in larval zebrafish
Authors: Palanca Ana Marie S. , Lee Sung‐Ling , Yee Laura E. , Joe‐Wong Carlee , Trinh Le A. , Hiroyasu Elizabeth , Husain Majid , Fraser Scott E. , Pellegrini Matteo , Sagasti Alvaro 
Published: August 2012

AbstractTo analyze somatosensory neuron diversity in larval zebrafish, we identified several enhancers from the zebrafish and pufferfish genomes and used them to create five new reporter transgenes. Sequential deletions of three of these enhancers identified small sequence elements sufficient to drive expression in zebrafish trigeminal and Rohon‐Beard (RB) neurons. One of these reporters, using the Fru.p2x3‐2 enhancer, highlighted a somatosensory neuron subtype that expressed both the p2rx3a and pkcα genes. Comparison with a previously described trpA1b reporter revealed that it highlighted the same neurons as the Fru.p2x3‐2 reporter. To determine whether neurons of this subtype possess characteristic peripheral branching morphologies or central axon projection patterns, we analyzed the morphology of single neurons. Surprisingly, although these analyses revealed diversity in peripheral axon branching and central axon projection, PKCα/p2rx3a/trpA1b‐expressing RB cells did not possess obvious characteristic morphological features, suggesting that even within this molecularly defined subtype, individual neurons may possess distinct properties. The new transgenes created in this study will be powerful tools for further characterizing the molecular, morphological, and developmental diversity of larval somatosensory neurons. © 2012 Wiley Periodicals, Inc., 2013
Synthesis of [MoS4]2––M (M = Cu and Cd) Clusters: Potential NMR Spectroscopic Structural Probes for the Orange Protein
Authors: Maiti Biplab K. , Avilés Teresa , Matzapetakis Manolis , Moura Isabel , Pauleta Sofia R. , Moura José J. G. 
Published: August 2012

AbstractTwo synthetic strategies of tetrathiomolybdate‐metal clusters with the potential to be used as NMR structural probes for the location of the metal cofactor in the orange protein (ORP) are described. The first strategy is based on the substitution reaction in which small organic ligands bind directly to the metal centre in a molybdenum–copper hetero‐dinuclear cluster. Interaction between [PPh4]2[MoS4CuCl] and either aliphatic [β‐mercaptoethanol (b‐me)] or aromatic [o‐aminobenzenethiol (abt)] thiols in the presence of a strong base resulted in the formation of [Ph4P]2[S2MoS2Cu(b‐me)] (1a) and [Et4N]2[S2MoS2Cu(abt)]·H2O·0.25DMF (1b), which can be used to obtain intermolecular NOEs. The compound 1a readily hydrolyzed to [Ph4P]2[OSMoS2Cu(b‐me)] (1ahydro) in contact with a protic solvent. The second strategy consisted of the incorporation of cadmium into tetrathiomolybdate ([MoS4]2–), which gives rise to the trinuclear cluster compound [PPh4]2[(MoS4)2Cd] (2). All clusters were characterized spectroscopically and their structure determined by X‐ray diffraction. The NMR spectroscopic data are consistent with the formation of a complex with a 1:1 ratio of {MoS4Cu} and thiol. The 113Cd NMR chemical shift of compound 2 is consistent with the cadmium having a tetrahedral geometry and coordinated by four sulfur ligands. The tetraphenylphosphonium cation in compound 1a was replaced by a tetramethylammonium countercation originating in the water‐soluble compound [Me4N‐1a]. Solubility in aqueous buffers is a requirement for incorporating this cluster into apo‐ORP. These compounds will be used to identify the exact location of the ORP heterometallic cluster using NMR methodologies.