bluuebunny/crossref_metadata_2025_split huggingface dataset:
Infertility and Male Mating Behavior Deficits Associated With Pde1c in Drosophila melanogaster
Authors: Morton David B , Clemens-Grisham Rachel , Hazelett Dennis J , Vermehren-Schmaedick Anke 
Published: June 2010

Abstract
Pde1c is a calcium/calmodulin-regulated, dual-specificity cyclic nucleotide phosphodiesterase. We have used a transposon insertion line to investigate the physiological function of Pde1c in Drosophila melanogaster and to show that the insertion leads to male sterility and male mating behavior defects that include reduced copulation rates. Sterility appears to be primarily due to elimination of sperm from the female reproductive system. The male mating behavior defects were fully rescued by expression of exogenous Pde1c under the control of either a Pde1c or a pan-neuronal promoter, whereas the sterility could be only partially rescued by expression of exogenous Pde1c under the control of these promoters. We also show that Pde1c has a male-specific expression pattern in the CNS with an increased number of Pde1c-expressing neurons in the abdominal ganglion in males.
Bap170, a Subunit of the Drosophila PBAP Chromatin Remodeling Complex, Negatively Regulates the EGFR Signaling
Authors: Rendina Rosaria , Strangi Agostino , Avallone Bice , Giordano Ennio 
Published: June 2010

Abstract
BAP and PBAP constitute the two different forms of the Drosophila melanogaster Brahma chromatin remodelers. A common multisubunit core, containing the Brahma ATPase, can associate either with Osa to form the BAP complex or with Bap170, Bap180, and Sayp to constitute the PBAP complex. Although required for many biological processes, recent genetic analyses revealed that one role of the BAP complex during Drosophila wing development is the proper regulation of EGFR target genes. Here, we show that Bap170, a distinctive subunit of the PBAP complex, participates instead in the negative regulation of EGFR signaling. In adults, loss of Bap170 generates phenotypes similar to the defects induced by hyperactivation of the EGFR pathway, such as overrecruitment of cone and photoreceptor cells and formation extra veins. In genetic interactions, bap170 mutations suppress the loss of veins and photoreceptors caused by mutations affecting the activity of the EGFR pathway. Our results suggest a dual requirement of the PBAP complex: for transcriptional repression of rhomboid and for efficient expression of argos. Interestingly, genetic evidence also indicates that Bap170-mediated repression of rho is inhibited by EGFR signaling, suggesting a scenario of mutual antagonism between EGFR signaling and PBAP function.
Four-Year Treatment and Radiographic Outcomes of 1-Piece Implants Used in Immediate Function: A Prospective Study in a Single Private Practice
Authors: Hahn Jack A. 
Published: June 2010

Abstract
The aim of this study was to prospectively evaluate treatment outcomes of 1-piece implants (NobelDirect and NobelPerfect, Nobel Biocare AB, Gothenberg, Sweden) in routine private clinical practice. Forty-seven implants placed in 30 subjects demonstrated a cumulative survival rate of 97.9% with stable marginal bone levels after 4 years of loading.
Doses of Insulin and Its Analogues and Cancer Occurrence in Insulin-Treated Type 2 Diabetic Patients
Authors: Mannucci Edoardo , Monami Matteo , Balzi Daniela , Cresci Barbara , Pala Laura , Melani Cecilia , Lamanna Caterina , Bracali Ilaria , Bigiarini Michela , Barchielli Alessandro , Marchionni Niccol̀o , Rotella Carlo Maria 
Published: June 2010

OBJECTIVE
Recent epidemiological studies suggested that some insulin analogues could be associated with increased risk of cancer. The present study is aimed at assessing the long-term association of different insulin analogues with cancer incidence.

RESEARCH DESIGN AND METHODS
A nested case-control study dataset was generated from the cohort study dataset (n = 1,340 insulin-treated diabetic outpatients) by sampling control subjects from the risk sets. For each case subject, the control subjects (up to five) were chosen randomly from those members of the cohort who are at risk for the same follow-up time of the case subject. Five-year age classes, sex, and BMI classes (&lt;18.5, 18.5–24.9, 25–29.9, and ≥30 kg/m2) were considered as additional categorical matching variables.

RESULTS
During a median follow-up of 75.9 months (interquartile range 27.4–133.7), 112 case subjects of incident cancer were compared with 370 matched control subjects. A significantly higher mean daily dose of glargine was observed in case subjects than in control subjects (0.24 IU/kg/day [0.10–0.39] versus 0.16 IU/kg/day [0.12–0.24], P = 0.036). Incident cancer was associated with a dose of glargine ≥0.3 IU/kg/day even after adjusting for Charlson comorbidity score, other types of insulin administration, and metformin exposure (odds ratio 5.43 [95% CI 2.18–13.53], P &lt; 0.001). No association between incident cancer and insulin doses was found for human insulin or other analogues.

CONCLUSIONS
The possibility of association between cancer and higher glargine doses suggests that dosages should always be considered when assessing the possible association of insulin and its analogues with cancer.
Interaction of methoxy- and methylenedioxyamphetamines with carbon and polymeric adsorbents in polar liquids
Authors: Tomaszewski Waldemar , Gun’ko Vladimir , Leboda Roman , Skubiszewska-Zięba Jadwiga 
Published: June 2010

Abstract
Solid phase extraction (SPE) of methoxy- and methylenedioxyamphetamines from diluted aqueous solutions was investigated on carbon and polymeric adsorbents of different textures and chemical compositions. Those adsorbents were applied cartridges packed with three chemically modified carbons prepared from plum stones (initial A2PS, oxidized A2PS-O, and reduced A2PS-H) and commercially available adsorbents (polymeric LiChrolut EN, graphitized Hypercarb and Carboprep). Several factors influence the recovery rates of amphetamine derivatives such as the polarity of adsorbates (free energy of salvation), the specific surface area and surface composition of adsorbents, and the solvent characteristics. Different combinations of these factors affect the recovery rate (R1) for high- and low-surface area adsorbents. The minimal R1 values are observed for an amphetamine derivative at a maximal solvation effect and for a set of amphetamines adsorbed on graphitized carbons.
Synthesis, characterization, catalytic and antimicrobial studies of ruthenium(III) complexes
Authors: Thilagavathi Natarajan , Jayabalakrishnan Chinnasamy 
Published: June 2010

Abstract
Ru(III) complexes of the type [RuXB(L)2] have been prepared by the reaction of 3,4-dihydropyrimidin-2(1H)-ones/thiones (HL1–HL4) with the precursors of the type [RuX3B3] where X=Cl or Br; B=PPh3 or AsPh3 and L is the deprotonated ligand. The synthesized complexes were characterized by physico-chemical methods, electrochemical and magnetic moment data. The catalytic efficiency of the complexes were examined in the oxidation of alcohols and antimicrobial studies were also carried out.
Spectroscopic, thermal and toxicity studies of some 2-amino — 3- cyano — 1, 5 -diphenylpyrrole containing Schiff bases copper (II) complexes
Authors: El-Boraey Hanaa , Abdel-Rahman Randa , Atia Ensaf , Hilmy Khalid 
Published: June 2010

Abstract
Two novel Schiff base ligands of 2-amino-3-cyano-1,5-diphenylpyrrole and salicylaldehyde (HL1) or 2- hydroxy1-naphthylaldehyde (HL2) and their copper(II) complexes have been synthesized and characterized by elemental analyses, spectral (UV-Vis, IR, EPR, Mass (for ligands)), thermal (DTA-TGA) methods, magnetic and conductance measurements. IR results demonstrate the bidentate binding of the Schiff base ligands involving azomethine nitrogen, phenolic or naphtholic oxygen and suggest the presence of HL2 and complexes (1, 2, 4 and 8) in enolimine-ketonamine tautomeric forms in the solid state. The EPR spectral data of complexes (2, 5, 6) show that the metal — ligand bonds have considerable covalent character. The thermal studies show that complexes (1, 2, 4 and 8) that are present in enolimine-ketonamine tautomeric forms exhibit lower thermal stability. The effect of synthesized ligands (HL1, HL2) and complexes (1, 5) were tested on the mortality of entomopathogenic nematodes (EPN) (Heterorhabditis bacteriophora and Steinernema carpocapsae). The study shows that the mortality of the nematodes increased with increasing concentrations of copper(II) ion, ligands and complexes. Copper(II) ion was the most toxic for EPN.
Modeling the activity of 2-phenylnaphthalene inhibitors using self-training artificial neural networks
Authors: Garkani-Nejad Zahra , Jalili-Jahani Naser 
Published: June 2010

Abstract
The present study investigates the quantitative structure-activity relationship (QSAR) of 2-phenylnaphthalene ligands on an estrogen receptor (ERα). A data set comprising 70 derivatives of 2-phenylnaphthalene is used. The most suitable parameters, classified as topological, geometric and electronic are selected using a combination of genetic algorithm and multiple linear regression (GA-MLR) methods. Then, selected descriptors are used as inputs for a self-training artificial neural network (STANN). Analysis of the results suggests that the STANN model shows superior results compared to the multiple linear regressions (MLR) by accounting for 91.0% of the variances of the antiseptic potency of the 2-phenylnaphthalene derivatives. The accuracy of the 8-4-1 STANN model is illustrated using leave-multiple-out (LMO) cross-validation and Y-randomization techniques.
Preparation and utilization of a molecularly imprinted polymer for solid phase extraction of tramadol
Authors: Azodi-Deilami Saman , Abdouss Majid , Hasani Seyed 
Published: June 2010

Abstract
In this paper, a highly selective molecularly imprinted polymer (MIP) for tramadol hydrochloride, a drug used to treat moderate to severe pain, was prepared and its use as solid-phase extraction (SPE) sorbent was demonstrated. The molecularly imprinted solid-phase extraction procedure followed by high performance liquid chromatography with ultraviolet detector (MISPE-HPLC) was developed for selective extraction and determination of tramadol in human plasma and urine. The optimal conditions for molecularly imprinted solid-phase extraction (MISPE) consisted of conditioning with 1 mL methanol and 1 mL of deionized water at neutral pH, loading of tramadol sample (50 µg L−1) at pH 7.5, washing using 1 mL acetone and elution with 3 × 1 mL of 10% (v/v) acetic acid in methanol. The MIP selectivity was evaluated by checking several substances with similar molecular structures to that of tramadol. Results from the HPLC analyses showed that the calibration curve of tramadol (using MIP from human plasma and urine) is linear in the ranges of 6–100 and 3–120 µg L−1 with good precisions (1.9% and 2.9% for 5.0 µg L−1), respectively. The recoveries for plasma and urine samples were higher than 81%.
Formation and study of mixed copper sulfide-copper telluride layers on the surface of polyamide 6
Authors: Janickis Vitalijus , Žalenkienė Skirma 
Published: June 2010

Abstract
The layers of mixed copper chalcogenides, CuxS-CuyTe, were formed on the surface of polyamide using solutions of potassium and sodium telluropentathionates, K2TeS4O6 and Na2TeS4O6, respectively, and of telluropentathionic acid, H2TeS4O6, as precursors of chalcogens. The concentration of sorbed chalcogens increased with the increasing time of the treatment, concentration and temperature of precursor solution. CuxS-CuyTe layers are formed on the surface of polyamide after the treatment of chalcogenized polymer with Cu(II/I) salt solution. The concentration of copper in the layer increases with the increase of chalcogenization duration, concentration and the temperature of chalcogenization solution. In the surface of CuxS-CuyTe layers various copper, sulfur, tellurium and oxygen compounds (Cu2S, CuS, S8, CuxS, CuyTe, Cu(OH)2 and TeO2) were present. Chalcogenides were the major components in the layer. Chalcogenide phases — digenite, Cu1.8S, djurleite, Cu1.9375S, anilite, Cu7S4, geerite, CuS2, chalcocite, Cu2S, tetragonal Cu3.18Te2, Cu2.72Te, hexagonal Cu2Te, Cu4Te3, Cu1.80Te, Cu1.85Te2, and orthorhombic vulcanite, CuTe were identified in the layers by X-ray diffraction. Electrical sheet resistance of CuxS-CuyTe layers vary from ∼ 1.0 kW cm−2 to 4×103 kΩ cm−2. It is concluded that the formation of chalcogenide layers proceeds in the form of islands which grow into larger agglomerates. Use of the gathered data enables design and formation of the CuxS-CuyTe layers with desired conductivities.
Inter-molecular physiochemical characterization for etodolac-hydroxypropyl-β-cyclodextrin polymeric systems in solid and liquid state
Authors: Sinha Vivek , Amita  , Chadha Renu , Goel Honey 
Published: June 2010

Abstract
The purpose of this study was to explore the utility of hydroxypropyl-β-cyclodextrin (HP-β-CD) systems in forming inclusion complexes with the anti-rheumatic or anti-arthritic drug, etodolac (EDC), in order to overcome the limitation of its poor aqueous solubility. This inclusion system achieved high solubility for the hydrophobic molecule. The physical and chemical properties of each inclusion compound were investigated. Complexes of EDC with HP-β-CD were obtained using the kneading and co-evaporation techniques. Solid state characterization of the products was carried out using Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), powder X-ray diffraction (XRD) and Scanning electron microscopy (SEM). Studies in the solution state were performed using UV-Vis spectrophotometry and 1H-NMR spectroscopy. Phase solubility profiles with HP-β-CD employed was found to be AL type. Stability constants (Kc) from the phase solubility diagrams were calculated indicating the formation of 1:1 inclusion complex. Stability studies in the solid state and in liquid state were performed; the possible degradation by RP-HPLC was monitored. The dissolution studies revealed that EDC dissolution rate was improved by the formation of inclusion complexes.
PXPd-catalyzed borylation of aniline derivatives
Authors: Wheaton Susan , Humanayun Kabir S. , Zhang Haiwen , Vogels Christopher , Decken Andreas , Westcott Stephen 
Published: June 2010

Abstract
Addition of pinacolborane (HBO2C2Me4) to 2-iodoaniline can be catalyzed using a number of palladium complexes, including [(t-Bu)2PCl]2PdCl2 (PXPd), to give the corresponding boronate ester 2-H2NC6H4(BO2C2Me4) in excellent yields. The PXPd system could also be used in the catalyzed borylation of substituted anilines to give the corresponding aminoboronate esters in moderate to high yields.
LΣ(≤ ω)-spaces and spaces of continuous functions
Authors: Lara Israel , Okunev Oleg 
Published: June 2010

AbstractWe present a few results and problems related to spaces of continuous functions with the topology of pointwise convergence and the classes of LΣ(≤ ω)-spaces; in particular, we prove that every Gul’ko compact space of cardinality less or equal to $$ \mathfrak{c} $$ is an LΣ(≤ ω)-space.
Determinants of post-partum amenorrhea among Nepalese rural mothers: A multivariate analysis
Authors: Aryal TR 
Published: June 2010

Introduction: Post-partum amenorrhea (PPA) is the duration variable, which is directly related to the levels of fertility. The timing of occurrence of the first menstruation after delivery is known as the duration of PPA. It is a temporary infecundable period where mothers are most likely to be free from possible conception. Objective: This paper investigates the determinants of the duration of PPA in relation to some characteristics of mother and her child by using both current as well as retrospective status reporting data. Materials and methods: Data are taken from a sample survey of rural Palpa and Rupandehi districts. A sample of 1019 ever-married mothers was interviewed. Of them, 642 mothers were provided PPA information for their last birth child, and 481 mothers were provided PPA information for their last but one child. Cox proportional hazard model analysis has been utilized to identify the determinants of PPA duration. Results: A lower relative risk of PPA period was found among mothers who have higher parity, larger birth interval and longer period of breastfeeding (BF). Education was inversely associated with PPA, and about 1.5 times higher risk of returning menstruation early was found among educated mothers as compared uneducated counter-part. BF is significantly associated with PPA where the longer is the duration of BF the longer is the duration of PPA. The relative risk was found increased with increases the level of socio-economic status. Over twice times higher risk of returning menstruation early was found among mothers who had experienced dead child as compared to mothers who have no child loss. Conclusion: The variables like birth interval, parity, breastfeeding, education, socio-economic status and child survival are found the main determinants of PPA duration among Nepalese mothers. Key words: Post-partum amenorrhea; breastfeeding; fertility DOI: 10.3126/kumj.v8i1.3214 Kathmandu University Medical Journal (2010), Vol. 8, No. 1, Issue 29, 5-11
Physicians and communities knowledge and awareness about new vaccines in immunization program: A study to derive lesson for increasing uptake
Authors: Lahariya C , Khandekar J , Vachher AS , Pradhan SK 
Published: June 2010

Background: The knowledge, attitude of physicians about any interventions has effect on the practices while the perceptions about such intervention by caregivers have impact on the acceptance in community. Objectives: This study was conducted to assess the knowledge and attitude of physicians and perception of the caregivers about new vaccines, and to identify the solutions to address the knowledge gap, if any. Materials and methods: A cross sectional study was conducted a major city of India from Sept 2006-Jan 2007. 107 physicians and 298 caregivers were interviewed using a pre-tested semi structured interview schedule. The data so collected was analyzed using chi square test and proportions. P value of less than 0.05 was considered statistically significant. Results: It was found that only 3/5th physicians were aware that typhoid vaccination was part of the immunisation program. The knowledge about all the aspects of typhoid was poor amongst physicians in comparison of other vaccine (Hepatitis B) in the immunisation program. Physicians at private health facilities had poor knowledge than those working at government health facilities. However, majority of the physicians had positive attitude towards typhoid vaccination. All the caregivers had heard about typhoid disease and 39.8% about the vaccine also. Almost 80% of them were ready to pay for typhoid vaccination. Conclusions: The study underlines the need for special efforts to increase the awareness about typhoid vaccination amongst these groups to increase the uptake of the vaccine. Key words: Child Health; Hepatitis B, India; Newer vaccines; Typhoid DOI: 10.3126/kumj.v8i1.3222 Kathmandu University Medical Journal (2010), Vol. 8, No. 1, Issue 29, 51-56
The Modern Language Curriculum in a Technological University: A Non-departmentalized Case Study
Authors: Boschetto-Sandoval Sandra , Deneire Marc , Sandoval Ciro 
Published: June 2010

In the following study we outline the mission of a technological university and the place of a non-departmentalized modern language program within this context. We discuss the perception of the modern language program and its curriculum by the administration, the faculty, and the students, whose competing discourses must be addressed in order to bring about effective curricular change. We go on to discuss the changes we have already implemented, and others that are still in the process of implementation. The results of recent surveys and interviews undertaken show that while faculty might place a higher value on LSP courses, the pragmatic motivation in learning a language does not come first for our students. Other motives - travel, leisure, culture appreciation - are at least equally important. While modern language faculty face considerable odds in retaining students in courses that may be perceived as less necessary for a technological education than the strictly technical in nature, needs analyses of Michigan Tech's institutional context show that these courses are not only desirable, but professionally as well as personally necessary to engineering students. The Modern Language Program at Michigan Tech is moving in the direction of a broader concept of modern language learning, one open to greater interdisciplinary and intercultural depth.
Vers une autonomie croissante de l'apprenant du français langue étrangère ?
Authors: Hoeflaak Arie , Verlopp Nico 
Published: June 2010

Dans cet article, nous présentons une étude sur les caractéristiques du français parlé. Notre pratique d'enseignement du français langue étrangère (FLE) a démontré qu'un certain nombre d'étudiants universitaires, même de niveau relativement avancé, éprouvent des difficultés de compréhension du journal parlé de Radio France Inter. Afin de déterminer un point de départ pour le développement d'une didactique élaborée de la com-préhension orale, nous avons consulté un certain nombre d'études descriptives sur les différences entre le français parlé et écrit afin de découvrir ce qui les distingue l'un de l'autre. Ensuite, à l'aide des quelques 10 000 mots d'un spécimen de 28 journaux parlés de Radio France Inter, nous avons étudié trois aspects particuliers du » français écrit oralisé «, soit l'intonation, la distribution des pauses et le débit. Il résulte de cette étude que plus de 50 % des phrases examinées ont une intonation montante, même s'il s'agit de phrases non-interrogatives (qui, selon les règles phonétiques » classiques «, devraient avoir une intonation descendante). Dans près de 50 % des phrases, les pauses qu'on retrouverait dans une version écrite du texte en forme de blancs ne figurent pas dans le texte parlé. Le débit de notre corpus est de 205 mots par minute en moyenne, ce qu'on pourrait considérer comme assez rapide selon certains (p. ex., Pimsleur, Hancock et Furey, 1977), ou normal, selon d'autres (p. ex., Caspers, 1994; Goldman-Eisler, 1968; Koopmans-van Beinum, 1992). Ces trois caractéristiques du journal parlé devraient être à la base d'une didactique du français parlé, avant même de passer à d'autres stratégies d'apprentissage du type » top-down «.