bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nomogram prediction of vessels encapsulating tumor clusters in small hepatocellular carcinoma ≤ 3 cm based on enhanced magnetic resonance imaging
Authors: Chen Hui-Lin , He Rui-Lin , Gu Meng-Ting , Zhao Xing-Yu , Song Kai-Rong , Zou Wen-Jie , Jia Ning-Yang , Liu Wan-Min 
Published: May 2024

BACKGROUND
Vessels encapsulating tumor clusters (VETC) represent a recently discovered vascular pattern associated with novel metastasis mechanisms in hepatocellular carcinoma (HCC). However, it seems that no one have focused on predicting VETC status in small HCC (sHCC). This study aimed to develop a new nomogram for predicting VETC positivity using preoperative clinical data and image features in sHCC (≤ 3 cm) patients.
AIM
To construct a nomogram that combines preoperative clinical parameters and image features to predict patterns of VETC and evaluate the prognosis of sHCC patients.
METHODS
A total of 309 patients with sHCC, who underwent segmental resection and had their VETC status confirmed, were included in the study. These patients were recruited from three different hospitals: Hospital 1 contributed 177 patients for the training set, Hospital 2 provided 78 patients for the test set, and Hospital 3 provided 54 patients for the validation set. Independent predictors of VETC were identified through univariate and multivariate logistic analyses. These independent predictors were then used to construct a VETC prediction model for sHCC. The model’s performance was evaluated using the area under the curve (AUC), calibration curve, and clinical decision curve. Additionally, Kaplan-Meier survival analysis was performed to confirm whether the predicted VETC status by the model is associated with early recurrence, just as it is with the actual VETC status and early recurrence.
RESULTS
Alpha-fetoprotein_lg10, carbohydrate antigen 199, irregular shape, non-smooth margin, and arterial peritumoral enhancement were identified as independent predictors of VETC. The model incorporating these predictors demonstrated strong predictive performance. The AUC was 0.811 for the training set, 0.800 for the test set, and 0.791 for the validation set. The calibration curve indicated that the predicted probability was consistent with the actual VETC status in all three sets. Furthermore, the decision curve analysis demonstrated the clinical benefits of our model for patients with sHCC. Finally, early recurrence was more likely to occur in the VETC-positive group compared to the VETC-negative group, regardless of whether considering the actual or predicted VETC status.
CONCLUSION
Our novel prediction model demonstrates strong performance in predicting VETC positivity in sHCC (≤ 3 cm) patients, and it holds potential for predicting early recurrence. This model equips clinicians with valuable information to make informed clinical treatment decisions.
Perioperative remedial antiviral therapy in hepatitis B virus-related hepatocellular carcinoma resection: How to achieve a better outcome
Authors: Mu Fan , Hu Liang-Shuo , Xu Kun , Zhao Zhen , Yang Bai-Cai , Wang Yi-Meng , Guo Kun , Shi Jian-Hua , Lv Yi , Wang Bo 
Published: May 2024

BACKGROUND
Although the benefits of antiviral therapy for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) have been proven, researchers have not confirmed the differences in patient outcomes between patients who received preoperative antiviral therapy for a period of time (at least 24 wk) and patients who received remedial antiviral therapy just before radical resection for HBV-related HCC.
AIM
To investigate the efficacy of perioperative remedial antiviral therapy in patients with HBV-related HCC.
METHODS
A retrospective study of patients who underwent radical resection for HBV-related HCC at the First Affiliated Hospital of Xi’an Jiaotong University from January 2016 to June 2019 was conducted. Considering the history of antiviral therapy, patients were assigned to remedial antiviral therapy and preoperative antiviral therapy groups.
RESULTS
Kaplan–Meier analysis revealed significant differences in overall survival (P < 0.0001) and disease-free survival (P = 0.035) between the two groups. Multivariate analysis demonstrated that a history of preoperative antiviral treatment was independently related to improved survival (hazard ratio = 0.27; 95% confidence interval: 0.08-0.88; P = 0.030).
CONCLUSION
In patients with HBV-related HCC, it is ideal to receive preoperative long-term antiviral therapy, which helps patients tolerate more extensive hepatectomy; however, remedial antiviral therapy, which reduces preoperative HBV-DNA levels to less than 4 Log10 copies DNA/mL, can also result in improved outcomes.
Predictive model using four ferroptosis-related genes accurately predicts gastric cancer prognosis
Authors: Wang Li , Gong Wei-Hua 
Published: May 2024

BACKGROUND
Gastric cancer (GC) is a common malignancy of the digestive system. According to global 2018 cancer data, GC has the fifth-highest incidence and the third-highest fatality rate among malignant tumors. More than 60% of GC are linked to infection with Helicobacter pylori (H. pylori) , a gram-negative, active, microaerophilic, and helical bacterium. This parasite induces GC by producing toxic factors, such as cytotoxin-related gene A, vacuolar cytotoxin A, and outer membrane proteins. Ferroptosis, or iron-dependent programmed cell death, has been linked to GC, although there has been little research on the link between H. pylori infection-related GC and ferroptosis.
AIM
To identify coregulated differentially expressed genes among ferroptosis-related genes (FRGs) in GC patients and develop a ferroptosis-related prognostic model with discrimination ability.
METHODS
Gene expression profiles of GC patients and those with H. pylori -associated GC were obtained from The Cancer Genome Atlas and Gene Expression Omnibus (GEO) databases. The FRGs were acquired from the FerrDb database. A ferroptosis-related gene prognostic index (FRGPI) was created using least absolute shrinkage and selection operator–Cox regression. The predictive ability of the FRGPI was validated in the GEO cohort. Finally, we verified the expression of the hub genes and the activity of the ferroptosis inducer FIN56 in GC cell lines and tissues.
RESULTS
Four hub genes were identified (NOX4, MTCH1, GABARAPL2, and SLC2A3 ) and shown to accurately predict GC and H. pylori -associated GC. The FRGPI based on the hub genes could independently predict GC patient survival; GC patients in the high-risk group had considerably worse overall survival than did those in the low-risk group. The FRGPI was a significant predictor of GC prognosis and was strongly correlated with disease progression. Moreover, the gene expression levels of common immune checkpoint proteins dramatically increased in the high-risk subgroup of the FRGPI cohort. The hub genes were also confirmed to be highly overexpressed in GC cell lines and tissues and were found to be primarily localized at the cell membrane. The ferroptosis inducer FIN56 inhibited GC cell proliferation in a dose-dependent manner.
CONCLUSION
In this study, we developed a predictive model based on four FRGs that can accurately predict the prognosis of GC patients and the efficacy of immunotherapy in this population.
Novel miR-490-3p/hnRNPA1-b/PKM2 axis mediates the Warburg effect and proliferation of colon cancer cells via the PI3K/AKT pathway
Authors: Wan Xiang-Hui , Jin Guo-Bing , Yang Qun , Hu Ji-Long , Liu Zhi-Liang , Rao Jun , Wen Can , Li Peng-Ling , Yang Xi-Mei , Huang Bo , Wang Xiao-Zhong 
Published: May 2024

BACKGROUND
Heterogeneous ribonucleoprotein A1 (hnRNPA1) has been reported to enhance the Warburg effect and promote colon cancer (CC) cell proliferation, but the role and mechanism of the miR-490-3p/hnRNPA1-b/PKM2 axis in CC have not yet been elucidated.
AIM
To investigate the role and mechanism of a novel miR-490-3p/hnRNPA1-b/PKM2 axis in enhancing the Warburg effect and promoting CC cell proliferation through the PI3K/AKT pathway.
METHODS
Paraffin-embedded pathological sections from 220 CC patients were collected and subjected to immunohistochemical analysis to determine the expression of hnRNPA1-b. The relationship between the expression values and the clinicopathological features of the patients was investigated. Differences in mRNA expression were analyzed using quantitative real-time polymerase chain reaction, while differences in protein expression were analyzed using western blot. Cell proliferation was evaluated using the cell counting kit-8 and 5-ethynyl-2’-deoxyuridine assays, and cell cycle and apoptosis were detected using flow cytometric assays. The targeted binding of miR-490-3p to hnRNPA1-b was validated using a dual luciferase reporter assay. The Warburg effect was evaluated by glucose uptake and lactic acid production assays.
RESULTS
The expression of hnRNPA1-b was significantly increased in CC tissues and cells compared to normal controls (P < 0.05). Immunohistochemical results demonstrated significant variations in the expression of the hnRNPA1-b antigen in different stages of CC, including stage I, II-III, and IV. Furthermore, the clinicopathologic characterization revealed a significant correlation between hnRNPA1-b expression and clinical stage as well as T classification. HnRNPA1-b was found to enhance the Warburg effect through the PI3K/AKT pathway, thereby promoting proliferation of HCT116 and SW620 cells. However, the proliferation of HCT116 and SW620 cells was inhibited when miR-490-3p targeted and bound to hnRNPA1-b, effectively blocking the Warburg effect.
CONCLUSION
These findings suggest that the novel miR-490-3p/hnRNPA1-b/PKM2 axis could provide a new strategy for the diagnosis and treatment of CC.
Mapping the intellectual structure and emerging trends for the application of nanomaterials in gastric cancer: A bibliometric study
Authors: Liu Bo-Na , Gao Xiao-Li , Piao Ying 
Published: May 2024

BACKGROUND
Recent reviews have outlined the main nanomaterials used in relation to gastrointestinal tumors and described the basic properties of these materials. However, the research hotspots and trends in the application of nanomaterials in gastric cancer (GC) remain obscure.
AIM
To demonstrate the knowledge structure and evolutionary trends of research into the application of nanomaterials in GC.
METHODS
Publications related to the application of nanomaterials in GC were retrieved from the Web of Science Core Collection for this systematic review and bibliometric study. VOSviewer and CiteSpace were used for bibliometric and visualization analyses.
RESULTS
From 2000 to 2022, the application of nanomaterials in GC developed rapidly. The keyword co-occurrence analysis showed that the related research topics were divided into three clusters: (1) The application of nanomaterials in GC treatment; (2) The application and toxicity of nanomaterials in GC diagnosis; and (3) The effects of nanomaterials on the biological behavior of GC cells. Complexes, silver nanoparticles, and green synthesis are the latest high-frequency keywords that represent promising future research directions.
CONCLUSION
The application of nanomaterials in GC diagnosis and treatment and the mechanisms of their effects on GC cells have been major themes in this field over the past 23 years.
Undifferentiated high-grade pleomorphic sarcoma of the common bile duct: A case report and review of literature
Authors: Zheng Li-Ping , Shen Wen-Yan , Hu Chun-Dong , Wang Chun-Hua , Chen Xu-Jian , Wang Jing , Shen Yi-Yu 
Published: May 2024

BACKGROUND
Undifferentiated pleomorphic sarcoma (UPS) is a rare malignant mesenchymal tumor with a poor prognosis. It mainly occurs in the extremities, trunk, head and neck, and retroperitoneum regions. Owing to the lack of specific clinical manifestations and imaging features, UPS diagnosis mainly depends on pathological and immunohistochemical examinations for exclusive diagnosis. Here we report an extremely rare case of high-grade UPS in the common bile duct (CBD). There are limited available data on such cases.
CASE SUMMARY
A 70-year-old woman was admitted to our department with yellow eyes and urine accompanied by upper abdominal distending pain for 2 wk. Her laboratory data suggested significantly elevated hepatorenal function levels. The imaging data revealed calculous cholecystitis, intrahepatic and extrahepatic bile duct dilation with extrahepatic bile duct calculi, and a space-occupying lesion at the distal CBD. After endoscopic biliary stenting and symptomatic support therapy, CBD exploration and biopsy were performed. The frozen section indicated malignant spindle cell tumor of the CBD mass, and further radical pancreaticoduodenectomy was performed. Finally, the neoplasm was diagnosed as a high-grade UPS combined with the light-microscopic morphology and immunohistochemical results.
CONCLUSION
This extremely rare case highlighted the need for increasing physicians' vigilance, reducing the odds of misdiagnosis, and providing appropriate treatment strategies.
Hubungan Pengetahuan Kepala Keluarga Dengan Perilaku Pencegahan Malaria Kampung Sakartemin
Authors: Weripang Imelda , Marti Eva , Ratnawati Emmelia 
Published: May 2024

Pendahuluan : Penyakit Malaria disebabkan oleh parasite plasmodium pada nyamuk betina yang terinfeksi dan menginfeksi manusia, dengan gejala panas dingin, menggigil serta demam berkepanjangan. Gejala Malaria biasanya muncul 10-15 hari setelah parasit masuk ke tubuh manusia. Penyakit Malaria disebabkan oleh pengaruh perilaku, gaya hidup dan lingkungan yang tidak sehat. Salah satu faktor yang mempengaruhi perilaku manusia ialah tingkat pengetahuan. Tujuan dari penelitian ini untuk mengetahui apakah ada hubungan antara pengetahuan dengan perilaku pencegahan malaria didesa sakartemen distrik fakfak tengah kabupaten fakfak papua barat. Metode : Desain penelitian deskriptif kuantitatif , jenis metode korelasi cross sectional, sampel dalam penelitian 97 responden. Alat ukur yang digunakan merupakan lembar kuisioner pengetahuan dan kuisioner perilaku pencegahan malaria yang diberikan kepada responden. Hasil : Tingkat pengetahuan baik sebanyak 64 responden dan pengetahuan cukup 26 responden dan tingkat perilaku pencegahan malaria kurang baik 66 responden dan perilaku pencegahan malaria baik 31 responden. Angka koefisien korelasi nilai r = 0,442 (korelasi lemah) dan p value = 0.000 (signifikan) berhubungan. Kesimpulan : Terdapat hubungan yang signifikan antara pengetahuan dengan perilaku pencegahan malaria dengan kekuatan korelasi lemah. Penelitian berikutnya disarankan mengambil studi kualitatif terkait faktor yang mempengaruhi perilaku kepala keluarga dalam pencegahan malaria.
Kata kunci : pengetahuan,perilaku pencegahan, penyakit malaria,faktor yang mempengaruhi perilaku.
Penggunaan Google Earth dalam Pembelajaran IPS
Authors: Ali Muhamad Khaedar , Kamal Astrid Liani , Safitri Desy , Sujarwo Sujarwo 
Published: May 2024

Pemanfaatan teknologi informasi dan komunikasi telah memberikan dampak yang signifikan terhadap dunia pendidikan, khususnya pembelajaran Ilmu Pengetahuan Sosial (IPS). Salah satu teknologi yang merevolusi pembelajaran ilmu sosial adalah Google Earth. Google Earth adalah aplikasi berbasis web yang menggabungkan citra satelit, peta, dan foto udara ke dalam platform interaktif untuk memberikan visualisasi tiga dimensi permukaan bumi. Penelitian ini bertujuan untuk mengkaji pemanfaatan Google Earth dalam pembelajaran IPS. Metode yang digunakan adalah tinjauan literatur dan analisis kualitatif studi kasus penggunaan Google Earth dalam berbagai konteks pembelajaran IPS.Studi ini menunjukkan bahwa Google Earth menawarkan berbagai keunggulan dalam pembelajaran ilmu sosial, antara lain visualisasi fenomena geografis dan sosial yang realistis, eksplorasi interaktif tempat sejarah dan budaya, serta analisis sebaran dan pola geografis. Selain itu, Google Earth memungkinkan Anda dengan mudah memasukkan konsep geografis dan sosial ke dalam pelajaran IPS, meningkatkan keterlibatan dan minat siswa melalui pengalaman belajar yang menarik dan interaktif. Namun, penelitian ini juga menyoroti beberapa tantangan dalam menggunakan Google Earth, termasuk keterbatasan aksesibilitas dan infrastruktur, serta perlunya pelatihan dan dukungan bagi guru untuk mengintegrasikan teknologi ini ke dalam kelas mereka. Oleh karena itu, penggunaan Google Earth dalam pendidikan ilmu sosial menjanjikan potensi besar dalam meningkatkan pemahaman siswa terhadap fenomena geografis dan sosial serta mengembangkan keterampilan analitis dan berpikir kritis. Namun, memaksimalkan manfaat teknologi ini untuk pembelajaran ilmu-ilmu sosial yang efektif dan berkelanjutan memerlukan upaya kolaboratif antara pendidik, pengembang teknologi, dan pemangku kepentingan lainnya.
Effect of School Principal Leadership, Discipline and Infrastructure on Teachers’ Performance in SMP Negeri Lempuing District, Ogan Komering Ilir Regency
Authors: Sari Rizky Fajar , Wati Sakdiah , Asiati Diah Isnaini 
Published: May 2024

This research aims to determine 1) the influence of the principal's leadership, discipline, and infrastructure together on the performance of State Middle School teachers in Lempuing District, Ogan Komering Ilir Regency, 2) the influence of the principal's leadership, discipline, and infrastructure partially on the performance of State Middle School teachers in the District. Lempuing, Ogan Komering Ilir Regency. The type of research used is associative. The research uses leadership variables, work discipline, facilities, infrastructure, and performance. The research population was 218 State Middle School teachers in Lempuing District, Ogan Komering Ilir Regency. The sample was taken from 142 teachers using the Cluster sampling technique. The data required is player data with a retrieval method. Questionnaire data. The analysis technique used is multiple linear regression. The results of the research prove that: 1) there is a significant influence of leadership, discipline, and facilities and infrastructure on the performance of State Middle School teachers in Lempuing District, Ogan Komering Ilir Regency 2) there is a significant influence of leadership on the performance of Public Middle School teachers in Lempuing District, Ogan Komering Ilir Regency 3) there is an influence Discipline has a significant impact on the performance of State Middle School teachers in Lempuing District, Ogan Komering Ilir Regency. 4) Facilities and infrastructure have a significant influence on the performance of public middle school teachers in Lempuing District, Ogan Komering Ilir Regency
educación popular y la construcción de paz: la experiencia de Colombia. Entrevista con Luis Guillermo Guerrero Guevara y Bertha Jaimes Carvajal
Authors: Schmelkes Sylvia 
Published: May 2024

Entrevista con Luis Guillermo Guerrero Guevara y Bertha Jaimes Carvajal sobre la educación popular y la construcción de paz en Colombia. Guerrero Guevara trabajó durante 35 años en el Programa por la Paz del Centro de Investigación y Educación Popular. Bertha Jaimes Carvajal participa en los procesos de formación del Programa Nacional para la Paz en distintos territorios en conflicto en Colombia.
Observationally constrained regional variations of shortwave absorption by iron oxides emphasize the cooling effect of dust
Authors: Obiso Vincenzo , Gonçalves Ageitos María , Pérez García-Pando Carlos , Perlwitz Jan P. , Schuster Gregory L. , Bauer Susanne E. , Di Biagio Claudia , Formenti Paola , Tsigaridis Kostas , Miller Ron L. 
Published: May 2024

Abstract. The composition of soil dust aerosols derives from the mineral abundances in the parent soils that vary across dust source regions. Nonetheless, Earth system models (ESMs) have traditionally represented mineral dust as a globally homogeneous species. The growing interest in modeling dust mineralogy, facilitated by the recognized sensitivity of the dust climate impacts to composition, has motivated state-of-the-art ESMs to incorporate the mineral speciation of dust along with its effect upon the dust direct radiative effect (DRE). In this work, we enable the NASA Goddard Institute for Space Studies ModelE2.1 to calculate the shortwave (SW) DRE accounting for the regionally varying soil mineralogy. Mineral–radiation interaction at solar wavelengths is calculated according to two alternative coupling schemes: (1) external mixing of three mineral components that are optically distinguished, one of which contains embedded iron oxides; (2) a single internal mixture of all dust minerals with a dynamic fraction of iron oxides that varies regionally and temporally. We link dust absorption to the fractional mass of iron oxides based on recent chamber measurements using natural dust aerosol samples. We show that coupled mineralogy overall enhances the scattering by dust, and thus the global cooling, compared to our control run with globally uniform composition. According to the external mixing scheme, the SW DRE at the top of atmosphere (TOA) changes from −0.25 to -0.30Wm-2, corresponding to a change in the net DRE, including the longwave effect, from −0.08 to -0.12Wm-2. The cooling increase is accentuated when the internal mixing scheme is configured: the SW DRE at the TOA becomes -0.34Wm-2 with a net DRE of -0.15Wm-2. The varying composition modifies the regional distribution of single scattering albedo (SSA), whose variations in specific regions can be remarkable (above 0.03) and significantly modify the regional SW DRE. Evaluation against the AErosol RObotic NETwork (AERONET) shows that explicit representation of soil mineralogy and its regional variations reduces the low bias of model dust SSA while improving the range of variability across stations and calendar months. Despite these improvements, the moderate spatiotemporal correlation with AERONET reveals remaining modeling challenges and the need for more accurate measurements of mineral fractions in soils.
A clinical case of atopic dermatitis with a rapid positive effect from the use of a genetically engineered biological drug in a teenager
Authors: Churyukina E. V. , Portnyaga E. A. 
Published: May 2024

Introduction. The instructions for the drug dupilumab indicate that the administration of a single loading dose on the first day leads to the rapid achievement of clinically effective concentrations within 2 weeks, which we saw in the example of our patient and her real clinical response to the first injection. Presentation of a clinical case. Under our medical supervision was a 17-year-old patient with severe atopic dermatitis, resistant to traditional therapy. Heredity for allergic pathology is burdened: the girl’s mother suffers from pollen allergy. Initially before the start of therapy: SCORAD — 88 points, EASI — 48.8 points, IGA — 4, blood eosinophils — 11 % (1188 cells/ml), total IgE — 1102.0 IU/ml; the content of nitric oxide in exhaled air (FeNO) is 30 ppb. On April 28, 2021, the patient was administered dupilumab at a dose of 600 mg. Assessment of atopic dermatitis control in points upon admission to the hospital 2 weeks after the first administration of dupilumab: on the SCORAD scale — 44.5 points; EASI — 13.8 points; IGA — 2 points, eosinophils — 9 % (1070 cells/ml); total IgE — 840 IU/ml; FeNO — 5 ppb. Conclusion. This clinical observation clearly illustrates the fact that patients with severe atopic dermatitis who don’t respond to first-line therapy can achieve positive clinical results after the first use of a recombinant human monoclonal antibody (IgG4).