bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physics to system-level modeling of silicon-organic-hybrid nanophotonic devices
Authors: Moridsadat Maryam , Tamura Marcus , Chrostowski Lukas , Shekhar Sudip , Shastri Bhavin J. 
Published: May 2024

AbstractThe continuous growth in data volume has sparked interest in silicon-organic-hybrid (SOH) nanophotonic devices integrated into silicon photonic integrated circuits (PICs). SOH devices offer improved speed and energy efficiency compared to silicon photonics devices. However, a comprehensive and accurate modeling methodology of SOH devices, such as modulators corroborating experimental results, is lacking. While some preliminary modeling approaches for SOH devices exist, their reliance on theoretical and numerical methodologies, along with a lack of compatibility with electronic design automation (EDA), hinders their seamless and rapid integration with silicon PICs. Here, we develop a phenomenological, building-block-based SOH PICs simulation methodology that spans from the physics to the system level, offering high accuracy, comprehensiveness, and EDA-style compatibility. Our model is also readily integrable and scalable, lending itself to the design of large-scale silicon PICs. Our proposed modeling methodology is agnostic and compatible with any photonics-electronics co-simulation software. We validate this methodology by comparing the characteristics of experimentally demonstrated SOH microring modulators (MRMs) and Mach Zehnder modulators with those obtained through simulation, demonstrating its ability to model various modulator topologies. We also show our methodology's ease and speed in modeling large-scale systems. As an illustrative example, we use our methodology to design and study a 3-channel SOH MRM-based wavelength-division (de)multiplexer, a widely used component in various applications, including neuromorphic computing, data center interconnects, communications, sensing, and switching networks. Our modeling approach is also compatible with other materials exhibiting the Pockels and Kerr effects. To our knowledge, this represents the first comprehensive physics-to-system-level EDA-compatible simulation methodology for SOH modulators.
Accretion of “young” Phanerozoic subcontinental lithospheric mantle triggered by back-arc extension—the case of the Ivrea-Verbano Zone
Authors: Ogunyele Abimbola C. , Sanfilippo Alessio , Salters Vincent J. M. , Bonazzi Mattia , Zanetti Alberto 
Published: May 2024

AbstractThe subcontinental lithospheric mantle (SCLM) beneath Phanerozoic regions is mostly constituted by fertile lherzolites, which sharply contrast with cratonic mantle made of highly-depleted peridotites. The question of whether this chemical difference results from lower degrees of melting associated with the formation of Phanerozoic SCLM or from the refertilization of ancient depleted SCLM remains a subject of debate. Additionally, the timing and geodynamic environment of accretion of the fertile SCLM in many Phanerozoic regions are poorly constrained. We here document new geochemical and Nd-Hf isotopic data for orogenic lherzolite massifs from the Ivrea-Verbano Zone (IVZ), Southern Alps. Even though a few Proterozoic Re depletion ages are locally preserved in these mantle bodies, our data reveal that the IVZ lherzolitic massifs were “recently” accreted to the SCLM in the Upper Devonian (ca. 370 Ma) during Pangea amalgamation, with a petrochemical evolution characterized by low-degree (~ 5–12%) depletion and nearly contemporaneous pervasive to focused melt migration. The lithospheric accretion putatively took place through asthenospheric upwelling triggered by Variscan intra-continental extension in a back-arc setting related to the subduction of the Rheic Ocean. We thus conclude that the fertile sections of Phanerozoic SCLM can be accreted during “recent” events of back-arc continental extension, even where Os isotopes preserve memories of melting events in much older times.
Multitasking across the lifespan in different task contexts
Authors: Van Humbeeck Nathan , Van Wilderode Mira , Kliegl Reinhold , van Wieringen Astrid , Krampe Ralf T. 
Published: May 2024

AbstractWe assessed lifespan development of multitasking in a sample of 187 individuals aged 8–82 years. Participants performed a visuo-spatial working memory (VSWM) task together with either postural control or reaction time (RT) tasks. Using criterion-referenced testing we individually adjusted difficulty levels for the VSWM task to control for single-task differences. Age-differences in single-task performances followed U-shaped patterns with young adults outperforming children and older adults. Multitasking manipulations yielded robust performance decrements in VSWM, postural control and RT tasks. Presumably due to our adjustment of VSWM challenges, costs in this task were small and similar across age groups suggesting that age-differential costs found in earlier studies largely reflected differences already present during single-task performance. Age-differences in multitasking costs for concurrent tasks depended on specific combinations. For VSWM and RT task combinations increases in RT were the smallest for children but pronounced in adults highlighting the role of cognitive control processes. Stabilogram diffusion analysis of postural control demonstrated that long-term control mechanisms were affected by concurrent VSWM demands. This interference was pronounced in older adults supporting concepts of compensation or increased cognitive involvement in sensorimotor processes at older age. Our study demonstrates how a lifespan approach can delineate the explanatory scope of models of human multitasking.
Continuity of GNSS as a critical attribute for safety applications in land transport
Authors: Filip Aleš , Rispoli Francesco 
Published: May 2024

AbstractThe Global Navigation Satellite System (GNSS) is widely used for air traffic management—more than 150,000 aircraft and 5000 airports worldwide are equipped with SBAS (Satellite-based augmentation system) technology, which contributes to safer and more efficient air operations. The next challenge is to extend GNSS positioning to maritime, autonomous cars and railway control systems preserving their safety requirements. The main parameter is the integrity of the GNSS positioning, although the time for which the integrity is guaranteed, defined by continuity, the most demanding requirement for aviation applications, has not been sufficiently investigated for land transportation. The aim of this paper is to close this gap by clarifying: (1) where the requirement for GNSS continuity comes from, (2) why GNSS continuity is needed in land transport, and (3) how GNSS-based applications can be made more reliable when needed. Using a comparative analysis, the continuity requirements in aviation, rail, maritime, and road transport have been investigated showing their importance for railways and automotive control, paving the way to eventually update the current EN 50126 (RAMS) and ISO/TR 4804 standards respectively for railways and automated cars. One of the main findings, through Markov modeling, is the improvement of the Mean Time to System Failure (MTTFsys) that for the railway safety-of-life applications can be significantly increased from about 521 h up to 5 × 105 h. These results can contribute to accelerating the adoption of GNSS positioning for automated land transportation, by exploiting the extensive experience brought by the aviation sector where GNSS was introduced 20 years ago.
Integrating blockchain and ZK-ROLLUP for efficient healthcare data privacy protection system via IPFS
Authors: Ma Shengchen , Zhang Xing 
Published: May 2024

AbstractWith the rapid development of modern medical technology and the dramatic increase in the amount of medical data, traditional centralized medical information management is facing many challenges. In recent years blockchain, which is a peer-to-peer distributed database, has been increasingly accepted and adopted by different industries and use cases. Key areas of healthcare blockchain applications include electronic medical record (EMR) management, medical device supply chain management, remote condition monitoring, insurance claims and personal health data (PHD) management, among others. Even so, there are a number of challenges in applying blockchain concepts to healthcare and its data, including interoperability, data security privacy, scalability, TPS and so on. While these challenges may hinder the development of blockchain in healthcare scenarios, they can be improved with existing technologies In this paper, we propose a blockchain-based healthcare operations management framework that is combined with the Interplanetary File System (IPFS) for managing EMRs, protects data privacy through a distributed approach while ensuring that this medical ledger is tamper-proof. Doctors act as full nodes, patients can participate in network maintenance either as light nodes or as full nodes, and the hospital acts as the endpoint database of data, i.e., the IPFS node, which saves the arithmetic power of nodes and allows the data stored in the hospitals and departments to be shared with the other organizations that have uploaded the data. Therefore, the integration of blockchain and zero-knowledge proof proposed in this paper helps to protect data privacy and is efficient, better scalable, and more throughput.
Active transport of a passive colloid in a bath of run-and-tumble particles
Authors: Dhar Tanumoy , Saintillan David 
Published: May 2024

AbstractThe dispersion of a passive colloid immersed in a bath of non-interacting and non-Brownian run-and-tumble microswimmers in two dimensions is analyzed using stochastic simulations and an asymptotic theory, both based on a minimal model of swimmer-colloid collisions characterized solely by frictionless steric interactions. We estimate the effective long-time diffusivity$${\mathscr {D}}$$Dof the suspended colloid resulting from its interaction with the active bath, and elucidate its dependence on the level of activity (persistence length of swimmer trajectories), the mobility ratio of the colloid to a swimmer, and the number density of swimmers in the bath. We also propose a semi-analytical model for the colloid diffusivity in terms of the variance and correlation time of the net fluctuating active force on the colloid resulting from swimmer collisions. Quantitative agreement is found between numerical simulations and analytical results in the experimentally-relevant regime of low swimmer density, low mobility ratio, and high activity.
Assessing the efficacy of 2D and 3D CNN algorithms in OCT-based glaucoma detection
Authors: Rasel Rafiul Karim , Wu Fengze , Chiariglione Marion , Choi Stacey S. , Doble Nathan , Gao Xiaoyi Raymond 
Published: May 2024

AbstractGlaucoma is a progressive neurodegenerative disease characterized by the gradual degeneration of retinal ganglion cells, leading to irreversible blindness worldwide. Therefore, timely and accurate diagnosis of glaucoma is crucial, enabling early intervention and facilitating effective disease management to mitigate further vision deterioration. The advent of optical coherence tomography (OCT) has marked a transformative era in ophthalmology, offering detailed visualization of the macula and optic nerve head (ONH) regions. In recent years, both 2D and 3D convolutional neural network (CNN) algorithms have been applied to OCT image analysis. While 2D CNNs rely on post-prediction aggregation of all B-scans within OCT volumes, 3D CNNs allow for direct glaucoma prediction from the OCT data. However, in the absence of extensively pre-trained 3D models, the comparative efficacy of 2D and 3D-CNN algorithms in detecting glaucoma from volumetric OCT images remains unclear. Therefore, this study explores the efficacy of glaucoma detection through volumetric OCT images using select state-of-the-art (SOTA) 2D-CNN models, 3D adaptations of these 2D-CNN models with specific weight transfer techniques, and a custom 5-layer 3D-CNN-Encoder algorithm. The performance across two distinct datasets is evaluated, each focusing on the macula and the ONH, to provide a comprehensive understanding of the models’ capabilities in identifying glaucoma. Our findings demonstrate that the 2D-CNN algorithm consistently provided robust results compared to their 3D counterparts tested in this study for glaucoma detection, achieving AUC values of 0.960 and 0.943 for the macular and ONH OCT test images, respectively. Given the scarcity of pre-trained 3D models trained on extensive datasets, this comparative analysis underscores the overall utility of 2D and 3D-CNN algorithms in advancing glaucoma diagnostic systems in ophthalmology and highlights the potential of 2D algorithms for volumetric OCT image-based glaucoma detection.
Semaglutide ameliorates pressure overload-induced cardiac hypertrophy by improving cardiac mitophagy to suppress the activation of NLRP3 inflammasome
Authors: He Wenxiu , Wei Jiahe , Liu Xing , Zhang Zhongyin , Huang Rongjie , Jiang Zhiyuan 
Published: May 2024

AbstractPathological cardiac hypertrophy is an important cause of heart failure(HF). Recent studies reveal that glucagon-like peptide-1 receptor (GLP1R) agonists can improve mortality and left ventricular ejection fraction in the patients with type 2 diabetes and HF. The present study aims to investigate whether semaglutide, a long-acting GLP1R agonist, can ameliorate cardiac hypertrophy induced by pressure overload, and explore the potential mechanism. The rats were performed transverse aortic constriction (TAC) to mimic pressure overload model. The rats were divided into four groups including Sham, TAC, TAC + semaglutide, and TAC + semaglutide + HCQ (hydroxychloroquine, an inhibitor of mitophagy). The rats in each experimental group received their respective interventions for 4 weeks. The parameters of left ventricular hypertrophy(LVH) were measured by echocardiography, Hematoxylin–eosin (HE) staining, western-blot and immunohistochemistry (IHC), respectively. The changes of mitophagy were reflected by detecting cytochrome c oxidase subunit II (COXII), LC3II/LC3I, mitochondria, and autophagosomes. Meanwhile, NLRP3, Caspase-1, and interleukin-18 were detected to evaluate the activation of NLRP3 inflammasome in each group. The results suggest that LVH, impaired mitophagy, and activation of NLRP3 inflammasome were present in TAC rats. Semaglutide significantly reduced LVH, improve mitophagy, and down-regulated NLRP3 inflammatory signal pathway in TAC rats. However, the reversed effect of semaglutide on cardiac hypertrophy was abolished by HCQ, which restored the activation of NLRP3 inflammasome suppressed by improved mitophagy. In conclusion, semaglutide ameliorates the cardiac hypertrophy by improving cardiac mitophagy to suppress the activation of NLRP3 inflammasome. Semaglutide may be a novel potential option for intervention of cardiac hypertrophy induced by pressure overload.
Tocilizumab is associated with reduced delirium and coma in critically ill patients with COVID-19
Authors: Alkhateeb Tuqa , Stollings Joanna L. , Sohn Ine , Liu Dandan , Fleenor L. Montana , Ely E. Wesley , Lahiri Shouri 
Published: May 2024

AbstractRecent preclinical studies demonstrate a direct pathological role for the interleukin-6 (IL-6) pathway in mediating structural and functional delirium-like phenotypes in animal models of acute lung injury. Tocilizumab, an IL-6 pathway inhibitor, has shown reduced duration of ventilator dependency and mortality in critically ill patients with COVID-19. In this study, we test the hypothesis that tocilizumab is associated with reduced delirium/coma prevalence in critically ill patients with COVID-19. 253 patients were included in the study cohort, 69 in the tocilizumab group and 184 in the historical control group who did not receive tocilizumab. Delirium was assessed using the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) with a positive score indicating delirium. Coma was defined as a Richmond Agitation-Sedation Scale score of − 4 or − 5. Tocilizumab was associated with significantly greater number of days alive without delirium/coma (tocilizumab [7 days (IQR: 3–9 days)] vs control [3 days (IQR: 1–8 days)]; p < 0.001). These results remained significant after adjusting for age, sex, sepsis, Charlson Comorbidity Index, Sequential Organ Failure Assessment score, and median daily dose of analgesics/sedatives ($$\hat{\upbeta }$$

β
^

= 0.671, p = 0.010). There were no significant differences in mortality ($$\hat{\upbeta }$$

β
^

= − 0.204, p = 0.561), ventilator duration ($$\hat{\upbeta }$$

β
^

= 0.016, p = 0.956), and ICU or hospital length of stay ($$\hat{\upbeta }$$

β
^

= − 0.134, p = 0.603; $$\hat{\upbeta }$$

β
^

= 0.003, p = 0.991, respectively). Tocilizumab use was associated with significantly increased number of days without delirium/coma. Confirmation of these findings in randomized prospective studies may inform a novel paradigm of pharmacological amelioration of delirium/coma during critical illness.
Evaluation of short and mid-term clinical outcomes in patients with aortic coarctation treated with self-expandable stents
Authors: Mohammadzadeh Shabestari Mahmoud , Eshraghi Ali , Hakim Attar Farnaz , Ghaderi Fereshteh , Poorzand Hoorak , Mohammadzadeh Shabestari Amir Hossein , Alizadeh Behzad , Morovatdar Negar , Shahri Bahram , Alimi Hedieh , Tayyebi Mohammad , Gholoobi Arash , Askari Vahid Reza , Garivani Yousef Ali , Mohammadzadeh Shabestari Mohammad , Baradaran Rahimi Vafa 
Published: May 2024

AbstractThe present study aimed to evaluate the outcomes of percutaneous treatment of aortic coarctation using self-expandable uncovered Nitinol stents. We conducted a retrospective clinical data review of all patients with aortic coarctation and treated with self-expandable uncovered Nitinol stents at our institution between 2009 and 2019. The gradient pressure across the coarctation site was measured using aortography. Follow-up echocardiography and computed tomography angiography were performed to assess possible stent complications. A total of 127 stents were successfully implanted in 125 patients (64.8% males) with a mean age of 35.36 ± 11.9 years. The gradient across the coarctation site decreased significantly from 67.48 ± 14.79 to 5.04 ± 3.01 mmHg (P < 0.001) after self-expandable stent implantation. Systolic blood pressure (SBP) decreased significantly from 175.53 ± 15.99 to 147.22 ± 12.83 mmHg (P < 0.001) after self-expandable stenting. There were no major technical or clinical complications, including balloon rupture, aneurysmal formation, infection, secondary stent migration, thrombosis, death during the procedure, and in-hospital mortality. On a mean follow-up of 48 ± 23.6 months (12–120 months), the gradient [from 59.43 ± 15.42 to 3.72 ± 1.38 mmHg (P < 0.001)] and SBP [from 175.53 ± 15.99 to 127.99 ± 7.82 mmHg (P < 0.001)] decreased significantly. There was no mortality, aneurysmal formation in the stent site, dislocation, or aortic re-stenosis requiring intervention during mid-term follow-up. Treatment of aortic coarctation using a self-expandable uncovered nitinol stent is safe and effective with promising mid-term outcomes.
COVID-19 was associated with the complications after allogeneic hematopoietic stem cell transplantation
Authors: Wen Qi , Guo Ze , Zhang Xiao-Hui , Xu Lan-Ping , Wang Yu , Yan Chen-Hua , Chen Huan , Chen Yu-Hong , Han Wei , Wang Feng-Rong , Sun Yu-Qian , Huang Xiao-Jun , Mo Xiao-Dong 
Published: May 2024

AbstractWe aimed to identify the severity and duration of COVID-19 infection on complications after allo-HSCT. Enrolled 179 hospitalized patients with COVID-19 were categorized into long-term infection (> 18 days, n = 90) or short-term infection group (≤ 18 days, n = 89) according to the median duration of COVID-19. The severity of COVID-19 was categorized as asymptomatic infection, mild, moderate, severe, and critical illness according to guidelines of National Institutes of Health. Particularly, severe illness and critical illness were classified as serious infection. Asymptomatic infection, mild illness and moderate illness were classified as non-serious infection. The 150-day probabilities of poor graft function (PGF), cytomegalovirus (CMV) pneumonia and non-relapse mortality (NRM) were significantly higher in long-term infection group. The 150-day probabilities of CMV pneumonia and NRM after COVID-19 were higher in serious infection group. The 150-day probabilities of overall survival (OS) was significantly lower in long-term and serious infection group. In multivariable analysis, the severity of COVID-19 was associated with NRM and OS, and the duration of COVID-19 was associated with PGF. In summary, our data reported that the severity and duration of COVID-19 were associated with several complications and contribute to poor outcomes after allo-HSCT.
Diabetes drugs activate neuroprotective pathways in models of neonatal hypoxic-ischemic encephalopathy
Authors: Poupon-Bejuit Laura , Geard Amy , Millicheap Nathan , Rocha-Ferreira Eridan , Hagberg Henrik , Thornton Claire , Rahim Ahad A 
Published: May 2024

AbstractHypoxic-ischaemic encephalopathy (HIE) arises from diminished blood flow and oxygen to the neonatal brain during labor, leading to infant mortality or severe brain damage, with a global incidence of 1.5 per 1000 live births. Glucagon-like Peptide 1 Receptor (GLP1-R) agonists, used in type 2 diabetes treatment, exhibit neuroprotective effects in various brain injury models, including HIE. In this study, we observed enhanced neurological outcomes in post-natal day 10 mice with surgically induced hypoxic-ischaemic (HI) brain injury after immediate systemic administration of exendin-4 or semaglutide. Short- and long-term assessments revealed improved neuropathology, survival rates, and locomotor function. We explored the mechanisms by which GLP1-R agonists trigger neuroprotection and reduce inflammation following oxygen-glucose deprivation and HI in neonatal mice, highlighting the upregulation of the PI3/AKT signalling pathway and increased cAMP levels. These findings shed light on the neuroprotective and anti-inflammatory effects of GLP1-R agonists in HIE, potentially extending to other neurological conditions, supporting their potential clinical use in treating infants with HIE.
Immunogenicity and efficacy of CNA25 as a potential whole-cell vaccine against systemic candidiasis
Authors: Sahu Satya Ranjan , Dutta Abinash , Peroumal Doureradjou , Kumari Premlata , Utakalaja Bhabasha Gyanadeep , Patel Shraddheya Kumar , Acharya Narottam 
Published: May 2024

AbstractDisseminated fungal infections account for ~1.5 million deaths per year worldwide, and mortality may increase further due to a rise in the number of immunocompromised individuals and drug-resistance fungal species. Since an approved antifungal vaccine is yet to be available, this study explored the immunogenicity and vaccine efficacy of a DNA polymerase mutant strain of Candida albicans. CNA25 is a pol32ΔΔ strain that exhibits growth defects and does not cause systemic candidiasis in mice. Immunized mice with live CNA25 were fully protected against C. albicans and C. parapsilosis but partially against C. tropicalis and C. glabrata infections. CNA25 induced steady expression of TLR2 and Dectin-1 receptors leading to a faster recognition and clearance by the immune system associated with the activation of protective immune responses mostly mediated by neutrophils, macrophages, NK cells, B cells, and CD4+ and CD8+ T cells. Molecular blockade of Dectin-1, IL-17, IFNγ, and TNFα abolished resistance to reinfection. Altogether, this study suggested that CNA25 collectively activates innate, adaptive, and trained immunity to be a promising live whole-cell vaccine against systemic candidiasis.