bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tissue‐Adhesive and Antibacterial Hydrogel Promotes MDR Bacteria‐Infected Diabetic Wound Healing via Disrupting Bacterial Biofilm, Scavenging ROS and Promoting Angiogenesis
Authors: Gao Yang , Chen Xinxin , Zou Zheng , Qi Desheng , Geng Yujia , Wang Zhen , Zhang Zhen , He Chaoliang , Yu Jiaao 
Published: February 2025

AbstractEffective treatment of diabetic wounds remains challenging because of multidrug‐resistant (MDR) bacterial infections, excessive oxidative stress, and impaired angiogenesis. In this study, a tissue‐adhesive and antibacterial hydrogel incorporating MXene and deferoxamine (DFO)‐loaded microspheres is developed for the treatment of MDR bacteria‐infected diabetic wounds. The hydrogel is built based on covalent crosslinking between ε‐poly(L‐lysine) and o‐phthalaldehyde‐terminated four‐arm poly(ethylene glycol). The hydrogel exhibited excellent mechanical properties, tissue adhesion strength, biocompatibility, and biodegradability. Under near‐infrared (NIR) irradiation, the MXene converted light into heat and elevated the local temperature rapidly, enabling the rapid disintegration of MDR bacterial biofilms. Simultaneously, the hydrogel exerted inherent antibacterial activity, persistently killing planktonic bacteria, and effectively controlling wound infections. The encapsulated DFO is then released from the hydrogel in a sustained and controlled manner, and promoted angiogenesis during diabetic wound healing. Additionally, MXenes can scavenge excessive reactive oxygen species and alleviate wound inflammation. In the methicillin‐resistant Staphylococcus aureus‐infected diabetic wound model in mice, the composite hydrogel along with NIR irradiation efficiently reduced the infectious bacteria, and accelerated the wound healing by promoting angiogenesis and alleviating inflammation. This composite hydrogel has great clinical potential for the treatment of diabetic wounds, particularly in challenging healing environments involving motion and infection.
An Enhanced Osseointegration of Titanium Implants by H2S Sustained‐Release Coating via Promoting Osteogenesis and Inhibiting Osteoclastogenesis
Authors: Xia Zuyan , Sun Xinyu , Mu Caiyun , Wang Kai , Ma Wenyu , Yang Wei , Xu Kui 
Published: February 2025

AbstractThe surfaces of titanium implants lack the ability of promoting osteogenesis and inhibiting osteoclastogenesis, which primarily contributes to their inadequate integration with surrounding bone tissue in osteoporotic environments. Developing a bioactive coating for the materials is regarded as a promising approach to address the challenge. In this study, a hydrogen sulfide (H2S) sustained‐release coating is fabricated on the surfaces of titanium implants. The coating consists of bovine serum albumin nanoparticles encapsulating the H2S donor morpholin‐4‐ium(4‐methoxyphenyl)‐morpholin‐4‐ylsulfanylidenesulfido‐λ5‐phosphane (GYY4137), which is prepared with the participation of dopamine self‐polymerization. The release rate of H2S could be precisely controlled by adjusting the crosslinking degree of the nanoparticles. The coating proves to have excellent biocompatibility and satisfactory hemocompatibility. In vitro, the coating could significantly promote the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and inhibit the osteoclastic differentiation of mouse monocytic macrophage leukemia cells (RAW264.7 cells). In vivo, this work successfully verifies the conclusion obtained in vitro experiments. The coating restores the bone homeostasis imbalance surrounding the functionalized titanium implants in the femurs of osteoporotic rats, thereby accelerating new bone formation and enhancing the osseointegration capability of the implants. This work provides a practical strategy for the development of titanium implants suitable for osteoporosis patients.
Low‐Volatility Fused‐Ring Solid Additive Engineering for Synergistically Elongating Exciton Lifetime and Mitigating Trap Density Toward Organic Solar Cells of 20.5% Efficiency
Authors: Song Xin , Zhang Busheng , Liu Xingting , Mei Le , Li Hongxiang , Yin Shanshan , Zhou Xinjie , Chen Huilong , Lin Yijin , Zhu Weiguo , Chen Xian‐Kai 
Published: February 2025

AbstractVolatile solid additives (VSAs) with single or fused‐ring structures have attracted much attention for enhancing power conversion efficiencies (PCEs) of organic solar cells (OSCs). While the working mechanisms of high‐volatility single‐ring additives have been well studied, the influence of low‐volatility fused‐ring VSAs on molecular aggregations and exciton/carrier dynamics remains still unclear. Herein, 3,6‐dibromothieno[3,2‐b]thiophene (3,6TTBr) is selected as a representative low‐volatility fused‐ring VSA to elucidate its working mechanism. Via the theoretical and experimental joint investigation, it is found that rigid and planar 3,6TTBr molecules adsorb onto the terminal units of L8‐BO (acceptor), inducing loose space for adjacent molecules. The low‐volatility 3,6TTBr thus favors the L8‐BO center‐terminal packing with a larger interfragment distance, which relieves the L8‐BO over‐aggregation and induces the ordered packing. Consequently, the 3,6TTBr treatment reduces aggregation‐caused quenching, enhancing the photoluminescence quantum yield and exciton lifetime of L8‐BO film. The combination of the above properties with the reduced trap density and improved carrier transport in the 3,6TTBr‐treated devices contributed to PCE of 20.1%. To validate the broad applicability of the findings, 1,5‐dibromonaphthalene (1,5‐BN), another low‐volatility fused‐ring solid, is explored. The devices with 1,5‐BN achieved an impressive PCE of 20.5%, verifying the validity of the low‐volatility fused‐ring VSA strategy for boosting OSC performances.
Rapid and Large‐Scale Synthesis of High‐Crystalline Imide Covalent Organic Frameworks Accelerated by Self‐Generated Water
Authors: Qin Yutian , Du Jing , Zhang Qingyun , Cheng Chuanqi , Dong Zefei , Zhang Qi , Li Shaopeng , Guo Jun , Tang Zhiyong , Zhao Meiting 
Published: February 2025

AbstractImide covalent organic frameworks (COFs) are considered promising materials in various fields due to their exceptional stability, large surface area, and high porosity. However, current synthesis methods of imide COFs typically involve complex vacuum operations, large amounts of solvents, and long reaction times at high temperatures, limiting their scalability for industrial production. Herein, a facile self‐accelerated strategy is developed for rapid, low‐cost, and large‐scale synthesis of eight imide COFs (SACOFs) under solvent‐free, vacuum‐free, and low‐temperature conditions. Mechanistic studies reveal that the self‐accelerated synthesis is driven by the self‐generated water under atmospheric conditions, which accelerates the reversible self‐healing of disordered polymers, ultimately leading to the rapid synthesis of highly crystalline COFs. Notably, the only additive required besides the COF monomers is o‐substituted benzoic acid, a small amount of which is grafted onto the imide COFs, enabling their straightforward functionalization. Thiol‐functionalized SACOFs are synthesized as supports for anchoring Pd nanoparticles. The as‐prepared Pd@SACOFs exhibit high activity and selectivity in the hydrogenation of substituted nitrobenzene due to the surface modulation of Pd by thiol groups. The self‐accelerated synthetic strategy enables rapid, low‐cost, and large‐scale production of imide COFs, potentially paving the way for their transition from laboratory research to commercial applications.
Deep‐Blue OLEDs with BT. 2020 Blue Gamut, External Quantum Efficiency Approaching 40%
Authors: Xiao Zhengqi , Zou Yang , Chen Zhanxiang , Miao Jingsheng , Qiu Yuntao , Huang Zhongyan , Cao Xiaosong , Peng Xiaojun , Yang Chuluo 
Published: February 2025

AbstractThe hyperfluorescence (HF) technology holds great promise for the development of high‐quality organic light‐emitting diodes (OLEDs) for their excellent color purity, high efficiency, and low‐efficiency roll‐off. Sensitizer plays a crucial role in the performance of HF devices. However, designing sensitizers with simultaneous high photoluminescence quantum yield (PLQY), rapid radiative decay (kr), and fast reverse intersystem crossing rate (kRISC) poses a great challenge, particularly for the thermally activated delayed fluorescence (TADF) sensitizers targeting deep‐blue HF device. Herein, by introducing a boron‐containing multi‐resonance‐type acceptor into the multi‐tert‐butyl‐carbazole encapsulated benzene molecular skeleton, two TADF emitters featuring hybridized multi‐channel charge‐transfer pathways, including short‐range multi‐resonance, weakened through‐bond, and compact face‐to‐face through‐space charge‐transfer. Benefiting from the rational molecular design, the proof‐of‐concept sensitizers exhibit simultaneous rapid kr of 5.3 × 107 s−1, fast kRISC up to 5.9 × 105 s−1, a PQLY of near‐unity, as well as ideal deep‐blue emission in both solution and film. Consequently, the corresponding deep‐blue HF devices not only achieve chromaticity coordinates that fully comply with the latest BT. 2020 standards, but also showcase record‐high maximum external quantum efficiencies nearing 40%, along with suppressed efficiency roll‐off.
Interfacially Weakened Förster Resonance Energy Transfer of Biocompatible Hole Transport Layers for Enhanced Perovskite Light‐Emitting Diodes
Authors: Huang Yuqiang , Wang Qungui , Mu Maolin , Pan Lunyao , Song Peng , Drafi Arslan Ahme , Yang Weiqing , Li Yuanzuo 
Published: February 2025

AbstractThe green, low‐cost, and biocompatible organic semiconductor chlorophyll (Chl) is an ideal alternative hole transport layer of perovskite light‐emitting diodes (PeLEDs). However, the excessive electrostatic interaction between the chlorophyll molecules and the perovskite luminescent layer can severely lead to a Förster resonance energy transfer (FRET) phenomenon at the interface and greatly reduce the performance of PeLEDs. Here, sodium copper chlorophyllin (NaCu‐Chl) with a unique “single‐point configuration” of negative electrostatic potential distribution is theoretically designed to effectively weaken the interfacial electrostatic anchoring effect and successfully suppress the interfacial FRET. Experimentally, its weaker interfacial FRET is proved to result in a stronger photoluminescence (PL) at 528 nm as well as a longer exciton lifetime. Furthermore, its more matched energy levels with perovskite can lead to a smaller hole injection barrier, effectively reducing nonradiative recombination. As a result, the NaCu‐Chl‐based PeLEDs device exhibits a higher external quantum efficiency (EQE) of 7.53%, 5.75 times luminance (65024 cd m−2), and 4.27 times half lifetime (T50) compared to Chl‐based PeLEDs. Evidently, this work provides a strategy to effectively suppress intrinsically strong FRET at the chlorophyll/perovskite interface for efficient PeLEDs and promotes the promising application of green, low‐cost, and biocompatible chlorophyll hole transport layer (HTL) in PeLEDs.
Density of States and Binding Energy Informatics for Exploring Early Disease Detection in MOF‐Metal Oxide Chemiresistive Sensors
Authors: Nurhuda Maryam , Otake Ken‐ichi , Kitagawa Susumu , Packwood Daniel M. 
Published: February 2025

AbstractHuman breath contains over 3000 volatile organic compounds, abnormal concentrations of which can indicate the presence of certain diseases. Recently, metal–organic framework (MOF)‐metal oxide composite materials have been explored for chemiresistive sensor applications, however their ability to detect breath compounds associated with specific diseases remains unknown. In this work, a new high‐throughput computational protocol for evaluating the sensing ability of MOF‐metal oxide toward small organic compounds is presented. This protocol uses a cluster‐based method for accelerated structure relaxation, and a combination of binding energies and density‐of‐states analysis to evaluate sensing ability, the latter measured using Wasserstein distances. This protocol is applied to the case of the MOF‐metal oxide composite material NM125‐TiO2 and is shown to be consistent with previously reported experimental results for this system. The sensing ability of NM125‐TiO2 for over 100 human‐breath compounds spanning 13 different diseases is examined. Statistical inference is then used to identify diseases which subsequent experimental efforts should focus on. Overall, this work provides new tools for computational sensor research, while also illustrating how computational materials science can be integrated into the field of preventative medicine.
An inter‐laboratory comparison of soil organic carbon analysis on a farm with four agricultural management systems
Authors: Brinton William , Basso Bruno , Millar Neville , Covey Kris , Bettigo Charles , Jagadamma Sindhu , Loeffler Frank 
Published: February 2025

AbstractSoil organic carbon (SOC) as a key soil health indicator is integral to the soil's capacity to function as a vital living ecosystem that sustains plants, animals, and humans. Accurate SOC estimation is essential to decision‐making for an increasing number of stakeholders, such as farmers, industry professionals, and policymakers, to determine the environmental benefit of agricultural practices, and more recently, allocate financial rewards through carbon market initiatives. Our study examined SOC variability in soils from four different regenerative management systems on a single farm using stratification and sample compositing, and analyzed by four different laboratories using dry combustion, the recommended analytical method, but one which varied according to laboratory standard operating procedures (SOP). Results showed significant variation in SOC levels for the same soil samples at different laboratories (1.6 ± 0.2 g kg−1), variation comparable to that between the distinct management systems (1.5 ± 0.4 g kg−1). Our findings show that analytical variability within and between laboratories must be considered, that use of the same laboratory, and to the extent possible the same SOP for successive SOC measurements at the same location is necessary, and that rigorous stratification alongside minimal sample consolidation should be conducted to generate analytical sample numbers that cater to logistics, economics, and scientific rigor.
Acute Myeloid Leukemia: 2025 Update on Diagnosis, Risk‐Stratification, and Management
Authors: Shimony Shai , Stahl Maximilian , Stone Richard M. 
Published: February 2025

ABSTRACTDisease OverviewAcute myeloid leukemia (AML) is a bone marrow stem cell cancer that is often fatal despite available treatments. Diagnosis, risk assessment, monitoring, and therapeutic management of AML have changed dramatically in the last decade due to increased pathophysiologic understanding, improved assessment technology, and the addition of at least 12 approved therapies.DiagnosisThe diagnosis is based on the presence of immature leukemia cells in the blood, and/or bone marrow or less often in extra‐medullary tissues. New biological insights have been integrated into recent classification systems.Risk AssessmentThe European Leukemia Network has published risk classification algorithms for both intensively and non‐intensively treated patients based on cytogenetic and on molecular findings. Prognostic factors may differ based on the therapeutic approach.MonitoringOur increasing ability to quantify lower levels of measurable residual disease (MRD) potentially allows better response assessment, as well as dynamic monitoring of disease status. The incorporation of MRD findings into therapeutic decision‐making is rapidly evolving.Risk Adapted TherapyThe availability of 12 newly approved agents has been welcomed; however, optimal strategies incorporating newer agents into therapeutic algorithms are debated. The overarching approach integrates patient and caregiver goals of care, comorbidities, and disease characteristics.
Prevalence of subjective cognitive decline and its association with physical health problems among urban community dwelling elderly population in South India
Authors: Menon Jayakumar , Kantipudi Suvarna Jyothi , Vinoth Stanley , Kuchipudi Jyothsna Devi 
Published: February 2025

AbstractINTRODUCTIONNo studies in India have explored subjective cognitive decline (SCD), a hallmark of stage II of preclinical Alzheimer's disease. This study aims to assess the prevalence and correlates of SCD in a South Indian, urban, elderly population.METHODSWe screened 403 individuals 60 years of age and older using the Subjective Memory Complaints Questionnaire (SMCQ) and measured objective cognition with the Montreal Cognitive Assessment (MoCA). Physical health parameters were evaluated for all participants.RESULTSAmong the participants, 377 (93.5%) reported subjective memory complaints. Of the 26 individuals without SCD, 15(57.7%) had objective cognitive impairment (MoCA <25). A total of 182 participants (45.2%) were identified with SCD. Higher educational attainment was significantly associated with fewer SCD reports and better cognitive performance (p < 0.001).DISCUSSIONSubjective cognitive decline (SCD) is highly prevalent among older adults. Screening for SCD can help identify individuals at risk for Alzheimer's disease. SCD assessement combined with cost‐effective biomarkers that confirms AD will help individuals to be identified for disease‐modifying therapies.Highlights
Nearly half of older adults population screened has reported subjective cognitive decline (SCD), highlighting the widespread occurrence of SCD in urban South India.
Participants with higher educational attainment had significantly fewer memory complaints and performed better on cognitive assessments.
SCD was prevalent even among individuals without major comorbid conditions such as diabetes and hypertension and those who were on regular treatment for metabolic and cardiovascular disorders.
Identifying subjective cognitive decline (SCD) can facilitate early and accurate diagnosis of cognitive disorders and help delay progression to dementia. This highlights the importance of developing and implementing improved public health strategies to address these challenges.
Further longitudinal studies are necessary to explore the progression of SCD to dementia, focusing on the interplay between cognitive health, biomarkers, and educational factors in the Indian population.
Influence of alpha‐synuclein on glucose metabolism in Alzheimer's disease continuum: Analyses of α‐synuclein seed amplification assay and FDG‐PET
Authors: Mak Elijah , Przybelski Scott A. , Wiste Heather J. , Fought Angela J. , Schwarz Christopher G. , Senjem Matthew L. , Jack Clifford R. , Lowe Val J. , Petersen Ronald C. , Boeve Bradley F. , O'Brien John T. , Kantarci Kejal ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: February 2025

AbstractINTRODUCTIONWe investigated the association between alpha‐synuclein (α‐syn) pathology and brain glucose metabolism across the cognitive spectrum of Alzheimer's disease (AD) co‐pathologies.METHODSFluorodeoxyglucose positron emission tomography (FDG‐PET) data from 829 Alzheimer's Disease Neuroimaging Initiative participants (648 cognitively impaired [CI], 181 unimpaired [CU]) were compared between α‐syn seed amplification assay (SAA) positive and negative groups. Interactions with cerebrospinal fluid (CSF) AD biomarkers were examined.RESULTSSAA+ was associated with widespread hypometabolism among CI individuals, particularly in posterior cortical regions, independent of CSF amyloid and tau levels in the occipital lobes. Regional hypometabolism mediated the effect of α‐syn SAA on disease severity in CI individuals, independent of CSF amyloid and tau levels. There were no influences of SAA on FDG‐PET in CU individuals.DISCUSSIONThis study supports a model in which α‐syn aggregation influences metabolic dysfunction, which then influences clinical disease severity, independent of AD. SAA+ could help optimize participant selection and outcome measures for clinical trials in AD.Highlights
α‐synuclein seed amplification positivity (SAA+) was associated with hypometabolism in cognitively impaired individuals.
Hypometabolism mediated the influence of α‐synuclein on disease severity.
Occipital hypometabolism in SAA+ was independent of cerebrospinal fluid levels of Alzheimer's disease pathology.
These findings can optimize future clinical trials targeting α‐synuclein pathology.
White matter injury, plasma Alzheimer's disease, and neurodegenerative biomarkers on cognitive decline in community‐dwelling older adults: A 10‐year longitudinal study
Authors: Hu Qili , Zhou Xiaowen , Xiao Zhenxu , Zhao Qianhua , Ding Ding , Zhang Jun 
Published: February 2025

AbstractINTRODUCTIONThis study aimed to investigate the synergistic impact of white matter injury, Alzheimer's disease, and neurodegenerative pathology on long‐term cognitive decline and dementia risk in older adults.METHODSWe included 262 dementia‐free participants with baseline and follow‐up interviews (2010–2021). At baseline, peak width of skeletonized mean diffusivity (PSMD) was assessed from diffusion tensor imaging. Plasma phosphorylated tau 217 (p‐tau217) and neurofilament light chain (NfL) were measured using a single‐molecule immune‐array assay. Cognitive function was evaluated using Mini‐Mental State Examination (MMSE) and domain‐specific cognitive tests.RESULTSParticipants with high‐level PSMD, p‐tau217, and NfL showed the fastest decline of MMSE (β = −0.30) and the highest dementia incidence of 3.54/100 person‐years. A combination model with three markers demonstrated a good predictive value for dementia, incorporating age, sex, education, and apolipoprotein E (area under the curve = 0.93, 95% confidence interval = 0.86, 0.99).DISCUSSIONCombining co‐pathology markers may identify individuals with a high risk of cognitive decline.Highlights
Peak width of skeletonized mean diffusivity (PSMD) was correlated with long‐term cognitive decline, and this correlation was modified by plasma phosphorylated tau (p‐tau)217 and neurofilament light chain (NfL).
Participants with high levels of PSMD, p‐tau217, and NfL showed the fastest cognitive decline and the highest risk of dementia.
A combination of the three markers exhibited a good predictive value of incident dementia over a 10‐year follow‐up period.