bluuebunny/crossref_metadata_2025_split huggingface dataset:
The long-term spatio-temporal trends in burden and attributable risk factors of major depressive disorder at global, regional and national levels during 1990–2019: a systematic analysis for GBD 2019
Authors: Mo Zhi-Yang , Qin Ze-Zhen , Ye Jun-Jie , Hu Xin-Xuan , Wang Rui , Zhao Ya-Ye , Zheng Ping , Lu Qiao-Shan , Li Qiao , Tang Xian-Yan 
Published: May 2024

Abstract

Aims
Caused by multiple risk factors, heavy burden of major depressive disorder (MDD) poses serious challenges to public health worldwide over the past 30 years. Yet the burden and attributable risk factors of MDD were not systematically known. We aimed to reveal the long-term spatio-temporal trends in the burden and attributable risk factors of MDD at global, regional and national levels during 1990–2019.

Methods
We obtained MDD and attributable risk factors data from Global Burden of Disease Study 2019. We used joinpoint regression model to assess the temporal trend in MDD burden, and age–period–cohort model to measure the effects of age, period and birth cohort on MDD incidence rate. We utilized population attributable fractions (PAFs) to estimate the specific proportions of MDD burden attributed to given risk factors.

Results
During 1990–2019, the global number of MDD incident cases, prevalent cases and disability-adjusted life years (DALYs) increased by 59.10%, 59.57% and 58.57%, respectively. Whereas the global age-standardized incidence rate (ASIR), age-standardized prevalence rate (ASPR) and age-standardized DALYs rate (ASDR) of MDD decreased during 1990–2019. The ASIR, ASPR and ASDR in women were 1.62, 1.62 and 1.60 times as that in men in 2019, respectively. The highest age-specific incidence, prevalence and DALYs rate occurred at the age of 60–64 in women, and at the age of 75–84 in men, but the maximum increasing trends in these age-specific rates occurred at the age of 5–9. Population living during 2000–2004 had higher risk of MDD. MDD burden varied by socio-demographic index (SDI), regions and nations. In 2019, low-SDI region, Central sub-Saharan Africa and Uganda had the highest ASIR, ASPR and ASDR. The global PAFs of intimate partner violence (IPV), childhood sexual abuse (CSA) and bullying victimization (BV) were 8.43%, 5.46% and 4.86% in 2019, respectively.

Conclusions
Over the past 30 years, the global ASIR, ASPR and ASDR of MDD had decreased trends, while the burden of MDD was still serious, and multiple disparities in MDD burden remarkably existed. Women, elderly and populations living during 2000–2004 and in low-SDI regions, had more severe burden of MDD. Children were more susceptible to MDD. Up to 18.75% of global MDD burden would be eliminated through early preventing against IPV, CSA and BV. Tailored strategies-and-measures in different regions and demographic groups based on findings in this studywould be urgently needed to eliminate the impacts of modifiable risk factors on MDD, and then mitigate the burden of MDD.
Provision of Telepsychological Care Via Email during COVID–19 Confinement: An Exploratory Study
Authors: Miguel-Álvaro Alejandro , Estupiñá Puig Francisco J. , Larroy Cristina 
Published: May 2024

Abstract
Within teletherapy, email interventions have been studied scarcely. For this reason, this exploratory study aims to characterize the assistance provided by email in a university telepsychology service and to compare the data with the assistance provided by telephone in the same service and period. For this purpose, the records of 81 users assisted via email during the COVID–19 pandemic lockdown in Spain were analyzed. The data were compared with those of the 338 users assisted by telephone in the same period. Despite its many limitations, results indicate high satisfaction with the email modality. Users express that they prefer a preference for using email when they do not feel safe in other ways. We found a lot of variation between the number of emails exchanged and the days that each case was active. Additionally, differences were found with telephone users in aspects such as age (email users being younger) and in a depression screening (email users scoring more positively). This study concludes on the high potential of this channel for the application of certain techniques (e.g., psychoeducation) or for people with certain characteristics.
Responses of Mesosphere Temperature to the Geomagnetic Storms on 8 and 15 September 2003
Authors: Sun Meng , Lu Jianyong , Li Jingyuan , Tang Fen , Wei Guanchun , Li Zheng , Yue Fulu , Xiong Shiping , Huang Ningtao 
Published: May 2024

AbstractThe impact of geomagnetic storms on the mesosphere temperature has been controversial and lacks direct observational evidence. The intricate chemical and physical processes in the mesosphere, combined with the scarcity of observations, pose challenges to achieving a thorough comprehension of storm‐induced turbulences in this region. Currently, some investigations have characterized temperature responses during geomagnetic storms and the focus has largely been on changes above mesopause (∼90 km). In this work, the responses of temperature in the mesosphere (75–95 km) to the storms on September 8 and 15, 2003 and its causes are studied using observations from the Sounding of the Atmosphere using Broadband Emission Radiometry (SABER) instrument onboard the Thermosphere Ionosphere Mesosphere Energetics and Dynamics (TIMED) satellite. It is found that (a) temperature responses for the moderate storm on September 15 manifest as increases within the latitude range of 80°S to 65°S, with peak values decreasing from approximately 15 K to around 7 K as latitude decreases, while for the minor strom of September 8 temperature changes only occur at ∼80°S with peaks of 7 K and −10 K, (b) the temperature responses can be transmitted down to 76–81 km, depending on the latitude and storm magnitude, and (c) there are significant fluctuations in both ozone (exceed 45%) and atomic oxygen (exceed 90%) after storm onset, highly correlated with temperature temporal and spatial variations. We suggest that the increases in ozone caused by the increases in atomic oxygen concentrations are the major contributor to rising temperature.
Impact of Microphysics Parameterization Schemes on the Assimilation of GOES‐16 ABI All‐Sky Infrared Radiances for a Bow Echo Analysis and Prediction
Authors: Kim Yu‐Shin , Wang Xuguang , Johnson Aaron 
Published: May 2024

AbstractThis study aims to investigate how assimilating GOES‐16 ABI infrared brightness temperature (BT) with different microphysics schemes affects the convection‐allowing analysis and prediction of the 3 May 2020 bow echo case. The Gridpoint Statistical Interpolation‐based Ensemble Kalman Filter (GSI‐EnKF) system and Weather Research and Forecasting (WRF) model are utilized to conduct data assimilation (DA) experiments using Thompson, WDM6, NSSL, and Morrison microphysics schemes. Correlation structures between BT and model state variables indicate that assimilating infrared BT can adjust bowing MCS dynamics via latent cooling and the rear inflow jet. Such corrections during DA cycling enhance the rear inflow jet and bow echo size, primarily for microphysics schemes featuring faster hydrometeor fall velocity and stronger latent cooling. The improved analyses lead to better forecasts of the bow echo's shape, size, timing of the bowing process, and wind speeds. Substituting a larger microphysics‐dependent effective radius for a constant default value increases prior BT, the magnitude of BT innovations, and accumulated impact on the rear inflow jet, especially for the WDM6 and Morrison schemes. In the subsequent forecasts, incorporating microphysics‐dependent effective radius further improves the experiment using the Morrison scheme but degrades it when using the WDM6 scheme.
The Monsoon's Influence on Central Asia's Subsequent Periods of Drought and Flooding
Authors: Nzabarinda Vincent , Bao Anming , Tie Liu , Ochege Friday Uchenna , Uwamahoro Solange , Kayiranga Alphonse , Bao Jiayu , Sindikubwabo Celestin , Li Tao 
Published: May 2024

AbstractCentral Asia and its southern neighbors are being ravaged by more frequent and intense droughts and floods. While research on droughts is abundant, their interaction with floods and monsoons, especially when originating in the south, has been understudied. This study employed temperature, precipitation, standardized precipitation evapotranspiration index (SPEI), and agricultural drought indices such as water deficit index (WDI), cumulative water deficit (CWD), and Palmer drought severity index (PDSI) to investigate the role of monsoons in increasing drought and flooding in the southern part of central Asia, including Afghanistan and Pakistan, over a 31‐year period. Findings revealed increasing severity and intensity of droughts over time, along with their duration and peaks, contrasting with irregular fluctuations in flood intensity. Rising regional temperatures coincide with declining precipitation. During summer monsoon (SM), average precipitation ranged from 0.03 mm/day (2004) to 0.05 mm/day (2010), with variations across the region. The temperature varied between −14.35°C (2009) and 37.05°C (1991), with a sharp increase up to 0.114°C in Turkmenistan and Uzbekistan, as well as in northern Pakistan, Afghanistan, and western Tajikistan. A temperature drop during SM was revealed on the Mountains range of Himalaya, Hindu Kush, Karakoram, Parmir, Kunlun Shan and Tian Shan, and in Pakistan, down to −0.054°C. WDI showed a strong positive connection (0.71 and 0.64) with temperature (Tmax and Tmin) and a weak negative correlation (−0.5) with precipitation during normal time. However, during the monsoon season, it demonstrated a negative correlation with both within a no significant (−0.08) range for maximum temperature.
Hydrometeorological Drivers of the 2023 Louisiana Water Crisis
Authors: Miller P. W. , Hiatt M. 
Published: May 2024

AbstractDuring summer and fall 2023, Louisiana experienced a historic local drought while dry conditions elsewhere in the central US withheld vital runoff from the Mississippi River, leading to below‐normal discharge into the Gulf of Mexico. Thus, by late October 2023, Louisiana was gripped by two super‐imposed water crises: a severe local drought and saltwater contamination in the Mississippi River channel. This study frames the development of the water emergency through the lens of flash drought using the Evaporative Demand Drought Index (EDDI). The EDDI shows south Louisiana experience a flash drought during June 2023, while the Mississippi River basin was subsequently characterized by large expanses of high‐percentile EDDI in August‐September 2023 shortly before the saltwater intrusion episode along the lower Mississippi River. Over the last 15 years, MRB‐wide EDDI percentile has oscillated between years‐long elevated and depressed states, accounting for 23.7% of the monthly discharge anomaly near New Orleans.
An E3 ligase TRIM1 promotes colorectal cancer progression via K63-linked ubiquitination and activation of HIF1α
Authors: Shi Liuliu , Fang Xianglan , Du Lijie , Yang Jin , Xue Juan , Yue Xiaokai , Xie Duoshuang , Hui Yuanjian , Meng Kun 
Published: May 2024

AbstractAccumulating studies have shown that E3 ligases play crucial roles in regulating cellular biological processes and signaling pathways during carcinogenesis via ubiquitination. Tripartite-motif (TRIM) ubiquitin E3 ligases consist of over 70 members. However, the clinical significance and their contributions to tumorigenesis remain largely unknown. In this study, we analyzed the RNA-sequencing expression of TRIM E3 ligases in colorectal cancer (CRC) and identified 10 differentially expressed genes, among which TRIM1 expression predicted poor prognosis of CRC patients. We demonstrated that TRIM1 expression is positively associated with CRC pathological stages, and higher expression is positively correlated with infiltrating levels of immune cells and immunotherapy biomarkers. TRIM1 expression promotes the proliferation and migration of colorectal cancer cells in vitro and in vivo. Transcriptional analysis showed that TRIM1 is responsible for metabolism promotion and immune suppression. Mechanistically, we found that TRIM1 binds HIF1α and mediates its K63-linked ubiquitination, which is required for HIF1α nuclear translocation and subsequent activation. Ubiquitination occurs at Lys214 in the loop between the two PAS domains of HIF1α, and mutation of Lys214 severely disturbs the function of HIF1α. Besides, HIF1α ubiquitination enhances its binding with proteins involved in cellular trafficking and nucleocytoplasmic transport pathway. Collectively, our results indicate TRIM1’s role in predicting prognosis and reveal how TRIM1 functions to upregulate HIF1α expression and promote tumor cell proliferation.
Causal effect of blood osteocalcin on the risk of Alzheimer’s disease and the mediating role of energy metabolism
Authors: Guo Xingzhi , Yang Yu-ying , Zhou Rong , Tian Ge , Shan Chang , Liu Jian-min , Li Rui 
Published: May 2024

AbstractGrowing evidence suggests an association between osteocalcin (OCN), a peptide derived from bone and involved in regulating glucose and lipid metabolism, and the risk of Alzheimer’s disease (AD). However, the causality of these associations and the underlying mechanisms remain uncertain. We utilized a Mendelian randomization (MR) approach to investigate the causal effects of blood OCN levels on AD and to assess the potential involvement of glucose and lipid metabolism. Independent instrumental variables strongly associated (P < 5E-08) with blood OCN levels were obtained from three independent genome-wide association studies (GWAS) on the human blood proteome (N = 3301 to 35,892). Two distinct summary statistics datasets on AD from the International Genomics of Alzheimer’s Project (IGAP, N = 63,926) and a recent study including familial-proxy AD patients (FPAD, N = 472,868) were used. Summary-level data for fasting glucose (FG), 2h-glucose post-challenge, fasting insulin, HbA1c, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, total cholesterol (TC), and triglycerides were incorporated to evaluate the potential role of glucose and lipid metabolism in mediating the impact of OCN on AD risk. Our findings consistently demonstrate a significantly negative correlation between genetically determined blood OCN levels and the risk of AD (IGAP: odds ratio [OR, 95%CI] = 0.83[0.72–0.96], P = 0.013; FPAD: OR = 0.81 [0.70–0.93], P = 0.002). Similar estimates with the same trend direction were obtained using other statistical approaches. Furthermore, employing multivariable MR analysis, we found that the causal relationship between OCN levels and AD was disappeared after adjustment of FG and TC (IGAP: OR = 0.97[0.80–1.17], P = 0.753; FPAD: OR = 0.98 [0.84–1.15], P = 0.831). There were no apparent instances of horizontal pleiotropy, and leave-one-out analysis showed good stability of the estimates. Our study provides evidence supporting a protective effect of blood OCN levels on AD, which is primarily mediated through regulating FG and TC levels. Further studies are warranted to elucidate the underlying physio-pathological mechanisms.
An antifouling membrane-fusogenic liposome for effective intracellular delivery in vivo
Authors: Kong Huimin , Zheng Chunxiong , Yi Ke , Mintz Rachel L. , Lao Yeh-Hsing , Tao Yu , Li Mingqiang 
Published: May 2024

AbstractThe membrane-fusion-based internalization without lysosomal entrapment is advantageous for intracellular delivery over endocytosis. However, protein corona formed on the membrane-fusogenic liposome surface converts its membrane-fusion performance to lysosome-dependent endocytosis, causing poorer delivery efficiency in biological conditions. Herein, we develop an antifouling membrane-fusogenic liposome for effective intracellular delivery in vivo. Leveraging specific lipid composition at an optimized ratio, such antifouling membrane-fusogenic liposome facilitates fusion capacity even in protein-rich conditions, attributed to the copious zwitterionic phosphorylcholine groups for protein-adsorption resistance. Consequently, the antifouling membrane-fusogenic liposome demonstrates robust membrane-fusion-mediated delivery in the medium with up to 38% fetal bovine serum, outclassing two traditional membrane-fusogenic liposomes effective at 4% and 6% concentrations. When injected into mice, antifouling membrane-fusogenic liposomes can keep their membrane-fusion-transportation behaviors, thereby achieving efficient luciferase transfection and enhancing gene-editing-mediated viral inhibition. This study provides a promising tool for effective intracellular delivery under complex physiological environments, enlightening future nanomedicine design.
Non-coplanar helimagnetism in the layered van-der-Waals metal DyTe3
Authors: Akatsuka Shun , Esser Sebastian , Okumura Shun , Yambe Ryota , Yamada Rinsuke , Hirschmann Moritz M. , Aji Seno , White Jonathan S. , Gao Shang , Onuki Yoshichika , Arima Taka-hisa , Nakajima Taro , Hirschberger Max 
Published: May 2024

AbstractVan-der-Waals magnetic materials can be exfoliated to realize ultrathin sheets or interfaces with highly controllable optical or spintronics responses. In majority, these are collinear ferro-, ferri-, or antiferromagnets, with a particular scarcity of lattice-incommensurate helimagnets of defined left- or right-handed rotation sense, or helicity. Here, we report polarized neutron scattering experiments on DyTe3, whose layered structure has highly metallic tellurium layers separated by double-slabs of dysprosium square nets. We reveal cycloidal (conical) magnetic textures, with coupled commensurate and incommensurate order parameters, and probe the evolution of this ground state in a magnetic field. The observations are well explained by a one-dimensional spin model, with an off-diagonal on-site term that is spatially modulated by DyTe3’s unconventional charge density wave (CDW) order. The CDW-driven term couples to antiferromagnetism, or to the net magnetization in an applied magnetic field, and creates a complex magnetic phase diagram indicative of competing interactions in this easily cleavable van-der-Waals helimagnet.
Emergent ribozyme behaviors in oxychlorine brines indicate a unique niche for molecular evolution on Mars
Authors: Hoog Tanner G. , Pawlak Matthew R. , Gaut Nathaniel J. , Baxter Gloria C. , Bethel Thomas A. , Adamala Katarzyna P. , Engelhart Aaron E. 
Published: May 2024

AbstractMars is a particularly attractive candidate among known astronomical objects to potentially host life. Results from space exploration missions have provided insights into Martian geochemistry that indicate oxychlorine species, particularly perchlorate, are ubiquitous features of the Martian geochemical landscape. Perchlorate presents potential obstacles for known forms of life due to its toxicity. However, it can also provide potential benefits, such as producing brines by deliquescence, like those thought to exist on present-day Mars. Here we show perchlorate brines support folding and catalysis of functional RNAs, while inactivating representative protein enzymes. Additionally, we show perchlorate and other oxychlorine species enable ribozyme functions, including homeostasis-like regulatory behavior and ribozyme-catalyzed chlorination of organic molecules. We suggest nucleic acids are uniquely well-suited to hypersaline Martian environments. Furthermore, Martian near- or subsurface oxychlorine brines, and brines found in potential lifeforms, could provide a unique niche for biomolecular evolution.
Designing meaningful continuous representations of T cell receptor sequences with deep generative models
Authors: Leary Allen Y. , Scott Darius , Gupta Namita T. , Waite Janelle C. , Skokos Dimitris , Atwal Gurinder S. , Hawkins Peter G. 
Published: May 2024

AbstractT Cell Receptor (TCR) antigen binding underlies a key mechanism of the adaptive immune response yet the vast diversity of TCRs and the complexity of protein interactions limits our ability to build useful low dimensional representations of TCRs. To address the current limitations in TCR analysis we develop a capacity-controlled disentangling variational autoencoder trained using a dataset of approximately 100 million TCR sequences, that we name TCR-VALID. We design TCR-VALID such that the model representations are low-dimensional, continuous, disentangled, and sufficiently informative to provide high-quality TCR sequence de novo generation. We thoroughly quantify these properties of the representations, providing a framework for future protein representation learning in low dimensions. The continuity of TCR-VALID representations allows fast and accurate TCR clustering and is benchmarked against other state-of-the-art TCR clustering tools and pre-trained language models.
Targeting SOX13 inhibits assembly of respiratory chain supercomplexes to overcome ferroptosis resistance in gastric cancer
Authors: Yang Hui , Li Qingqing , Chen Xingxing , Weng Mingzhe , Huang Yakai , Chen Qiwen , Liu Xiaocen , Huang Haoyu , Feng Yanhuizhi , Zhou Hanyu , Zhang Mengying , Pei Weiya , Li Xueqin , Fu Qingsheng , Zhu Liangyu , Wang Yingying , Kong Xiang , Lv Kun , Zhang Yan , Sun Yangbai , Ma Mingzhe 
Published: May 2024

AbstractTherapeutic resistance represents a bottleneck to treatment in advanced gastric cancer (GC). Ferroptosis is an iron-dependent form of non-apoptotic cell death and is associated with anti-cancer therapeutic efficacy. Further investigations are required to clarify the underlying mechanisms. Ferroptosis-resistant GC cell lines are constructed. Dysregulated mRNAs between ferroptosis-resistant and parental cell lines are identified. The expression of SOX13/SCAF1 is manipulated in GC cell lines where relevant biological and molecular analyses are performed. Molecular docking and computational screening are performed to screen potential inhibitors of SOX13. We show that SOX13 boosts protein remodeling of electron transport chain (ETC) complexes by directly transactivating SCAF1. This leads to increased supercomplexes (SCs) assembly, mitochondrial respiration, mitochondrial energetics and chemo- and immune-resistance. Zanamivir, reverts the ferroptosis-resistant phenotype via directly targeting SOX13 and promoting TRIM25-mediated ubiquitination and degradation of SOX13. Here we show, SOX13/SCAF1 are important in ferroptosis-resistance, and targeting SOX13 with zanamivir has therapeutic potential.
Antiferromagnetic magnonic charge current generation via ultrafast optical excitation
Authors: Huang Lin , Liao Liyang , Qiu Hongsong , Chen Xianzhe , Bai Hua , Han Lei , Zhou Yongjian , Su Yichen , Zhou Zhiyuan , Pan Feng , Jin Biaobing , Song Cheng 
Published: May 2024

AbstractNéel spin-orbit torque allows a charge current pulse to efficiently manipulate the Néel vector in antiferromagnets, which offers a unique opportunity for ultrahigh density information storage with high speed. However, the reciprocal process of Néel spin-orbit torque, the generation of ultrafast charge current in antiferromagnets has not been demonstrated. Here, we show the experimental observation of charge current generation in antiferromagnetic metallic Mn2Au thin films using ultrafast optical excitation. The ultrafast laser pulse excites antiferromagnetic magnons, resulting in instantaneous non-equilibrium spin polarization at the antiferromagnetic spin sublattices with broken spatial symmetry. Then the charge current is generated directly via spin-orbit fields at the two sublattices, which is termed as the reciprocal phenomenon of Néel spin-orbit torque, and the associated THz emission can be detected at room temperature. Besides the fundamental significance on the Onsager reciprocity, the observed magnonic charge current generation in antiferromagnet would advance the development of antiferromagnetic THz emitter.