bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shuangancistrotectorines A–E, Dimeric Naphthylisoquinoline Alkaloids with Three Chiral Biaryl Axes from the Chinese Plant Ancistrocladus tectorius
Authors: Xu Minjuan , Bruhn Torsten , Hertlein Barbara , Brun Reto , Stich August , Wu Jun , Bringmann Gerhard 
Published: March 2010

AbstractFive novel dimeric naphthylisoquinoline alkaloids, shuangancistrotectorines A (3 a), B (3 b), C (4), D (5 a), and E (5 b), have been isolated from the twigs of the Chinese plant Ancistrocladus tectorius. Their absolute stereostructures were determined by spectroscopic and chiroptical methods in combination with quantum chemical CD calculations. In contrast to all other known dimeric naphthylisoquinoline alkaloids, in which the central binaphthalene axis is 6′,6′′‐coupled and thus not rotationally hindered, the dimers described here are linked via the sterically more hindered 3′,3′′‐ or 1′,1′′‐positions of the naphthalene units. They are thus the first such dimers—and even the very first natural products at all—that have three consecutive stereogenic axes. Hence, including the stereogenic centers, they have up to seven stereogenic units in total. Some of the compounds, in particular shuangancistrotectorines A, B, and D (3 a, 3 b, and 5 a) exhibit very good, and specific, antiplasmodial activities.
Circular dichroism of donor–acceptor cyclophanes: (4Rp;12Rp)‐ and (4Sp;12Rp)‐12,15‐dimethoxy[2.2]paracyclophane‐4,7‐dicarboxylic acid derivatives
Authors: Furo Takahiro , Mori Tadashi , Inoue Yoshihisa 
Published: March 2010

AbstractThe electronic circular dichroism (CD) spectra were recorded for three diastereomeric eclipsed–staggered pairs of charge‐transfer cyclophanes with different substituents, i.e., (4Rp;12Rp)‐ and (4Sp;12Rp)‐12,15‐dimethoxy[2.2]paracyclophane‐4,7‐dicarboxylic acid derivatives (1a‐c and 2a‐c, where a, b, and c denote methyl ester, carboxylic acid, and carboxylate, respectively). The effects of altering the donor–acceptor interaction between the π systems on the chiroptical properties were experimentally investigated. The anisotropy (g) factors of eclipsed species 2 were not significantly affected by the sort of substituent, while staggered 1 behaved in a significantly different way in CD spectra depending on the charge, affording contrasting CD profiles for neutral a/b versus anionic c. This study provides not only the novel insights into the planar chirality of substituted [2.2]paracyclophanes but also a basis for the potential application of such dramatic CD spectral difference between the acid–base pair to the chiroptical pH‐sensors. Chirality 2010. © 2010 Wiley‐Liss, Inc.
Influence of Gender on Long‐term Prognosis of Patients With Chronic Heart Failure Seen in Heart Failure Clinics
Authors: Jiménez‐Navarro Manuel F. , Ramirez‐Marrero Miguel A. , Anguita‐Sánchez Manuel , Castillo Juan Carlos ,   for the BADAPIC Investigators
Published: March 2010

AbstractBackgroundControversy exists concerning the influence of gender in the prognosis of patients with heart failure and no evidence is available from specific heart failure clinics.HypothesisWomen with ambulatory heart failure are managed differently than men, although their prognosis might be better than men.Methods and ResultsWe analyzed the clinical characteristics, complementary test results, treatment, and prognosis in 4720 patients with chronic heart failure seen in 62 specialized clinics forming part of a multicenter registry during a mean follow‐up of 40 months. The mean age was 65 ± 12 years and 71% were men. The men were younger than the women and more often had a history of hyperlipidemia and ischemic heart disease. The men had a more advanced heart failure New York Heart Association (NYHA) functional class (III‐IV) than the women and a greater frequency of systolic ventricular dysfunction. The men more often received treatment with β‐blockers, vasodilators, and antiplatelet aggregators as well as higher mean doses as compared with the women. The overall survival after the follow‐up was similar for both genders, although the women had lower rates of survival free of admission for heart failure.ConclusionsDespite the mortality of women and men with heart failure being similar, the rate of readmission for heart failure is greater in women in specialized heart failure clinics. These results may be associated with the pharmacological treatment differences observed. Copyright © 2010 Wiley Periodicals, Inc.
Implications of Cheyne‐Stokes Breathing in Advanced Systolic Heart Failure
Authors: Amir Offer , Reisfeld Daniel , Sberro Hila , Paz Hagar , Mintz Shira , Lewis Basil S. 
Published: March 2010

AbstractBackgroundCheyne‐Stokes breathing (CSB) has been associated with heart failure (HF) patients for many years; however, its true prevalence and its prognostic implications are still obscure.HypothesisThe goal of this study was to investigate the prevalence and the possible prognostic implications of nocturnal CSB in advanced heart failure patients.MethodsWe performed single night full polysomonography ambulatory sleep studies in 71 HF patients. We analyzed the patients' sleep studies, clinical and laboratory data, and 6 month mortality.ResultsA total of 71 chronic systolic HF patients were analyzed, 60 males, 11 females, age 65 ± 13 years. Mean left ventricular ejection fraction was 27% ± 11%. Short episodes of CSB (at least 3 min duration) were present in all patients, and mean CSB duration was 1 hour. CSB duration was associated significantly with both high serum levels of N‐terminal prohormone brain natriuretic peptide (NT‐proBNP) as well as with 6 month mortality. Log CSB time had a significant correlation with log NT‐proBNP (r = 0.5, P<.0001). Based on median CSB duration, the Kaplan‐Meier survival curve analysis showed significant association with 6 month mortality (P = .03).ConclusionsCSB prevalence in advanced HF patients is higher than previously reported and is associated with increased serum levels of NT‐proBNP and higher 6 month mortality. Copyright © 2010 Wiley Periodicals, Inc.
Evaluation of Biventricular Functions With Tissue Doppler Imaging in Patients With Myotonic Dystrophy
Authors: Ozyigit Tolga , Ozben Beste , Oflaz Huseyin , Serdaroglu Piraye 
Published: March 2010

AbstractBackground:Myotonic dystrophy (MD) is characterized by myotonia with dystrophic involvement of the muscles. Cardiac involvement is usually not evident in the early stages of MD.Hypothesis:We investigated biventricular functions by tissue Doppler imaging (TDI) in MD patients with no overt cardiac involvement to explore the value of TDI in the early detection of myocardial dysfunction.Methods:A total of 21 MD patients (15 male, age: 32.2 ± 12.3 yrs) and 21 healthy controls (13 male, age: 32.2 ± 7.8 yrs) were included. In addition to conventional echocardiography, pulsed Doppler and TDI were performed including measurement of myocardial performance index (MPI); peak systolic (Sm) and early (Em) and atrial (Am) diastolic myocardial velocities at the basal mitral and tricuspid annulus.Results:All patients and controls had normal ejection fraction. Transmitral E peak velocity was significantly lower while both deceleration time of E velocity and isovolumic relaxation time were significantly longer in MD patients (P = 0.007, P = 0.001, and P < 0.001, respectively). Sm, Em and Am peak velocities were significantly lower in MD patients in all segments except for Em of the mitral anterior annulus and Am of the tricuspid lateral annulus. Both left and right ventricular MPI were significantly higher in MD patients (P < 0.001 and P = 0.013, respectively).Conclusion:There are changes in myocardial systolic and diastolic functions in MD patients although they have no overt heart failure. Myocardial tissue velocities and MPI are useful in identifying subclinical biventricular involvement in these patients. Copyright © 2010 Wiley Periodicals, Inc.
QRS Duration Is Associated With Atrial Fibrillation in Patients With Left Ventricular Dysfunction
Authors: El‐Chami Mikhael F. , Brancato Candace , Langberg Jonathan , Delurgio David B. , Bush Heather , Brosius Lynne , Leon Angel R. 
Published: March 2010

AbstractBackground:QRSduration (QRSd) is associated with higher mortality and morbidity in patients with left ventricular (LV) dysfunction. The association between QRSd and atrial fibrillation (AF) has not been studied in this patient population.Objectives:To investigate the association between QRSd and AF in patients with LV dysfunction.Methods:Data were obtained from the National Registry to Advance Heart Health (ADVANCENT) registry, a prospective multicenter registry of patients with left ventricular ejection fraction (LVEF) ≤ 40%. A total of 25 268 patients from 106 centers in the United States, were enrolled between June 2003 and November 2004. Demographic and clinical characteristics of patients were collected from interviews and medical records.Results:Mean age was 66.3±13 years, 71.5% were males, and 81.9% were white. A total of 14 452 (57.8%) patients had a QRSd < 120 ms, 5304 (21.2%) had a QRSd between 120 and 150 ms, and 5269 (21%) had a QRSd > 150 ms. Atrial fibrillation occurred in 20.9%, 27.5%, and 35.5% of patients in the QRS groups, respectively (P < 0.0001). After adjusting for potential AF risk factors (age, gender, race, body mass index, hypertension, diabetes, renal failure, cancer, lung disease, New York Heart Association [NYHA] class, ejection fraction, etiology of cardiomyopathy) and the use of angiotensin‐converting enzyme inhibitors, angiotensin receptor blockers, β‐blockers, and lipid lowering drugs, QRS duration remained independently associated with AF (odds ratio: 1.20, 95% confidence interval: 1.14–1.25).Conclusion:In this large cohort of patients, QRSd was strongly associated with AF and therefore may predict the occurrence of this arrhythmia in patients with LV dysfunction. This association persisted after adjusting for disease severity, comorbid conditions, and the use of medications known to be protective against AF. Copyright © 2010 Wiley Periodicals, Inc.
Grading Chronic Angina Pectoris (Myocardial Ischemia)
Authors: Conti C. Richard 
Published: March 2010

AbstractOnce it is determined that the patient's symptoms are thought to be due to chronic stable myocardial ischemia, the symptoms are then graded as 1 to 4 using the Canadian Cardiovascular Society classification (CCVS). Class 1‐angina with strenuous exertion, Class ll‐angina with moderate exertion, Class lll‐angina with mild exertion, Class lV‐angina with any level of physical exertion. Copyright © 2010 Wiley Periodicals, Inc.
Chiral Aryloxyalkylamines: Selective 5‐HT1B/1DActivation and Analgesic Activity
Authors: Carocci Alessia , Lentini Giovanni , Catalano Alessia , Cavalluzzi Maria Maddalena , Bruno Claudio , Muraglia Marilena , Colabufo Nicola Antonio , Galeotti Nicoletta , Corbo Filomena , Matucci Rosanna , Ghelardini Carla , Franchini Carlo 
Published: March 2010

AbstractA series of chiral 2,3‐dichlorophenoxy and 1‐naphthyloxy alkylamines were synthesized, and their binding affinities towards 5‐HT1Dand h5‐HT1Breceptors were evaluated. In the naphthyloxy series, the (R)‐prolinol derivative was the most selective 5‐HT1Dligand, while (S)‐N‐methyl‐2‐(1‐naphthyloxy)propan‐1‐amine showed the highest selectivity for h5‐HT1B. Both compounds performed as 5‐HT1Dagonists in the isolated guinea pig assay and showed higher analgesic activity than both sumatriptan and the achiral analogue20 bin the mouse hot‐plate test. Neither ligand displayed any affinity for nicotinic ACh receptors present in mouse brain membranes, thus indicating that their analgesic activity does not arise through interaction with these receptors.
E‐selectin targeting to visualize tumorsin vivo
Authors: Hirai Masahiko , Hiramatsu Yoshie , Iwashita Shinki , Otani Takayuki , Chen Ling , Li Yue‐guang , Okada Masashi , Oie Kazunori , Igarashi Koich , Wakita Hideaki , Seno Masaharu 
Published: March 2010

AbstractGenerally angiogenic factors induce the expression of E‐selectin in vascular endothelial cells in the tumors. In this study, we employed an anti‐E‐selectin monoclonal antibody to target tumors in vivo and evaluated an optical imaging reagent to visualize tumor regions. The anti‐E‐selectin antibody was conjugated on the surface of liposomes, which encapsulated the near‐infrared fluorescent substances Cy3 or Cy5.5. The liposomes efficiently recognized human umbilical vein endothelial cells only when E‐selectin was induced by angiogenic factors such as TNF‐α in vitro. Cy5.5 encapsulated into liposomes that were conjugated with an anti‐E‐selectin antibody successfully visualized Ehrlich ascites tumor cells when transplanted into mice. Thus, E‐selectin targeting with liposomes containing a near‐infrared fluorescent dye was found effective in visualizing tumors in vivo. This strategy should be extremely useful as a method to identify sentinel lymphatic nodes and angiogenic tumors as well as use for drug delivery to tumor cells. Copyright © 2010 John Wiley & Sons, Ltd.
Risk factors for fatigue severity in primary brain tumor patients
Authors: Armstrong Terri S. , Cron Stanley G. , Bolanos Elizabeth Vera , Gilbert Mark R. , Kang Duck‐Hee 
Published: March 2010

AbstractBACKGROUND:In addition to neurologic symptoms, fatigue is commonly reported in patients with primary brain tumors during radiation therapy and in long–term survivors of low–grade brain tumors. Other factors have not been explored. The aim of this study was to identify demographic and clinical factors that predict fatigue severity and to evaluate the association of fatigue with other symptoms throughout the disease trajectory.METHODS:Two hundred one patients with primary brain tumors completed the M. D. Anderson Symptom Inventory–Brain Tumor Module and a demographic checklist. Clinical data, including treatment, tumor grade, and performance status, were also collected. Correlations among fatigue and other recorded symptoms were evaluated. Logistic regression modeling was performed to evaluate factors associated with fatigue severity.RESULTS:Fatigue severity was associated with symptoms including pain, drowsiness, distress, difficulty sleeping, and weakness as well as overall symptom severity and interference. Poor performance status (Karnofsky scale) (odds ratio [OR], 5.73; P = .001), female sex (OR, 2.48; P = .005), and disease status (OR, 2.20; P = .013) were the strongest predictors of fatigue. Severity of fatigue for women was primarily predicted by disease status (OR, 3.33; P = .01) For men, antidepressant use (OR, 4.43; P = .013) in addition to opioids (OR, 3.46; P = .017) and performance status (OR, 12.47; P = .0001) predicted fatigue severity.CONCLUSIONS:Fatigue should not be considered a solitary symptom with 1 root cause, but a complex symptom related to the severity of other symptoms and potentially having various etiologies. Future studies should consider these factors in planning interventions and assessing response. Cancer 2010. © 2010 American Cancer Society.
Sustainable entrepreneurship in SMEs: a case study analysis
Authors: Rodgers Cheryl 
Published: March 2010

AbstractSustainability is oft thought of as the privilege of the large corporate – with sufficient funds to invest in anything from effective green Public Relations (PR) to improving its carbon footprint. What is perhaps less well‐understood and documented is the range of activities undertaken by small and medium enterprises (SMEs), including very small entrepreneurial start‐ups, some of which base their entire business rationale on sustainable principles. This paper uses a case study approach to explore the modus operandi of ecopreneurship and draws on both primary research and secondary data to develop and explore sustainable entrepreneurship in this sector. Preliminary findings suggest that ecopreneurial SMEs are looking to other goals alongside financial ones and are prepared to go to significant lengths to achieve such goals. Monetary measures are not, of course, entirely absent, but are very strongly conditioned by the ecoconscious nature of the business. In short, sustainability imperatives remain paramount. Copyright © 2010 John Wiley & Sons, Ltd and ERP Environment.
Dynamics of Filament Formation in Laser Produced Collisional Magnetoplasma
Authors: Singh A. , Aggarwal M. , Singh Gill T. 
Published: March 2010

AbstractThe paper presents an investigation of growth dynamics of spike in a collisional magneto plasma in the presence of externally applied magnetic field. We have set up and solved the non‐linear differential equations for growth and width of the laser spikes. We have considered the mechanism of nonuniform heating of carriers along the wavefront which is important in collisional plasmas. The effect of intensity of main beam and magnetic field on growth dynamics of spikes is studied (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Cytometry in cell necrobiology revisited. Recent advances and new vistas
Authors: Wlodkowic Donald , Skommer Joanna , Darzynkiewicz Zbigniew 
Published: March 2010

AbstractOver a decade has passed since publication of the last review on “Cytometry in cell necrobiology.” During these years we have witnessed many substantial developments in the field of cell necrobiology such as remarkable advancements in cytometric technologies and improvements in analytical biochemistry. The latest innovative platforms such as laser scanning cytometry, multispectral imaging cytometry, spectroscopic cytometry, and microfluidic Lab‐on‐a‐Chip solutions rapidly emerge as highly advantageous tools in cell necrobiology studies. Furthermore, we have recently gained substantial knowledge on alternative cell demise modes such as caspase‐independent apoptosis‐like programmed cell death (PCD), autophagy, necrosis‐like PCD, or mitotic catastrophe, all with profound connotations to pathogenesis and treatment. Although detection of classical, caspase‐dependent apoptosis is still the major ground for the advancement of cytometric techniques, there is an increasing demand for novel analytical tools to rapidly quantify noncanonical modes of cell death. This review highlights the key developments warranting a renaissance and evolution of cytometric techniques in the field of cell necrobiology. © 2010 International Society for Advancement of Cytometry
Genetic network underlying temperature‐dependent sex determination is endogenously regulated by temperature in isolated cultured Trachemys scripta gonads
Authors: Shoemaker‐Daly Christina M. , Jackson Kyle , Yatsu Ryohei , Matsumoto Yuiko , Crews David 
Published: March 2010

AbstractIn reptiles with temperature‐dependent sex determination, gonadogenesis is initially directed by the incubation temperature of the egg during the middle third of embryonic development. The mechanism by which temperature is transduced into a sex‐determining molecular signal remains a mystery, and here we examine the molecular network underlying sex determination in gonads in vitro. We use a whole organ culture system to show that expression of putative members of the sex‐determining network (Dmrt1, Sox9, Mis, and FoxL2) are regulated by temperature endogenously within cells in the bipotential gonad and do not require other embryonic tissues to be expressed in a normal pattern in the red‐eared slider turtle, Trachemys scripta. Furthermore, following a change in temperature, these factors exhibit temperature‐responsive expression patterns that last for the duration of gonadogenesis. Finally, mosaic misexpression of a fusion Sox9 construct demonstrates the ability to functionally manipulate the gonad at the molecular level. Developmental Dynamics 239:1061–1075, 2010. © 2010 Wiley‐Liss, Inc.
Reaction of Double Ylide C(PPh3)2 with [W(CO)6] – Crystal Structures of [(CO)5­W(CCPPh3)] and [(CO)5W{η1‐O2C2(PPh3)2}] and Bonding Analyses of [TM­(CCPR3)] Compounds
Authors: Petz Wolfgang , Neumüller Bernhard , Tonner Ralf 
Published: March 2010

AbstractThe photochemically generated complex [(CO)5W(thf)] reacts with C(PPh3)2 (1) to provide the salt (HC{PPh3}2)2[W2(CO)10] (5) in high yield by abstraction of a proton from the solvent thf. With [W(CO)6], a slow reaction in benzene occurs to give a mixture of [(CO)5W{O2C2(PPh3)2}] (6) and the heterocumulene (phosphonioacetylide) complex [(CO)5W(CCPPh3)] (7) by a Wittig type reaction. Both compounds were characterized by spectroscopic and X‐ray diffraction analyses. Theoretical density functional calculations reveal that the ligand CCPPh3 in 7 and in similar complexes is a strong σ‐donor but weak π‐acceptor.
Studies in Solution and the Solid State of Coordination Compounds Derived from LiBH4, NaBH4, and Bidentate Aromatic Amines
Authors: Aguilar‐Martínez Milagros , Félix‐Baéz Genaro , Pérez‐Martínez César , Nöth Heinrich , Flores‐Parra Angelina , Colorado Raul , Galvez‐Ruiz Juan Carlos 
Published: March 2010

AbstractThe mixture of 2,2′‐bipyridylamine, 2,2′‐bipyridine, 1,10‐phenanthroline, 1,2‐phenylendiamine, and 1,4‐phenylendiamine each with LiBH4 and NaBH4 in a 1:1 molar ratio in THF yields seven new complexes of the type MBH4·L‐THF and one complex of the type MBH4·L. These compounds were characterized by IR and NMR spectroscopy and X‐ray single‐crystal structure determinations. In the solid state, the [BH4]– group is bidentate, as deduced from the stretching patterns observed in IR spectra and confirmed by X‐ray single‐crystal structure analysis. NMR spectroscopy showed that all amines act as bidentate ligands and are symmetrically coordinated to the metal cation. Complexes LiBH4‐2,2′‐bipyridine‐THF (1), NaBH4‐2,2′‐bipyridine‐THF (2), LiBH4‐1,10‐phenanthroline‐THF (3), and NaBH4‐1,10‐phenanthroline‐THF (4) have a discrete molecular structure, whereas the complexes LiBH4‐1,2‐phenylendiamine‐THF (5), NaBH4‐1,2‐phenylendiamine‐THF (6), LiBH4‐2,2′‐dipyridilamine (7), and LiBH4‐1,4‐phenylendiamine‐THF (8) have polymeric structures in the solid state. N‐borane‐dipyridylamine adduct 9 was isolated from an aged solution of 7. IR spectroscopy of the new complexes showed that the structures of complexes 1, 3, 4, and 6 are maintained in the solid state and in solution. A rotational barrier for the [BH4]– group of less than 38 KJ mol–1 was estimated for some of the new complexes.