bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laser interstitial thermal therapy in neurosurgery: a single-surgeon experience of 313 patients
Authors: Gurses Muhammet Enes , Lu Victor M. , Gecici Neslihan Nisa , Gökalp Elif , Shah Khushi Hemendra , Metzler Ashley Rose , Chandar Jay , Merenzon Martin A. , Shah Ashish H. , Ivan Michael E. , Komotar Ricardo J. 
Published: June 2024

OBJECTIVE
Real-time MRI-guided focused laser interstitial thermal therapy (LITT) is a minimally invasive surgical treatment choice for challenging intracranial lesions that are either resistant to conventional therapies or located in deep or critical areas of the brain. However, existing studies on LITT within surgical neuro-oncology are relatively small and have limited follow-up periods. The authors aimed to present a comprehensive analysis of their experiences with LITT in surgical neuro-oncology, with the intent to provide a clearer understanding of the safety and efficacy of this procedure.

METHODS
This study was an exploratory cohort analysis encompassing all patients who underwent LITT for brain tumors at a single center between 2013 and 2023. The primary focus was extent of ablation (EOA), time to recurrence (TTR), and overall survival (OS). Secondary outcomes, including the rate of complications, were also evaluated. Comparative analyses were conducted based on lesion subtypes, and factors predicting outcomes were identified.

RESULTS
Three hundred thirteen patients underwent LITT procedures. During a mean follow-up of 10.4 months, 66.8% of patients remained alive and 26.2% of the ablated lesions recurred. The mean age of the cohort was 60.4 ± 13.3 years (58.5% female). The lesion subtypes that were treated comprised metastases (30%), glioblastoma (GBM; 41.6%), low-grade glioma (9.1%), radiation necrosis (11.4%), and meningioma (2.2%). The permanent neurological deficit rate was 14% (n = 44), with 25 (8%) of them new-onset deficits and 19 deficits (6.1%) that were present preoperatively and did not resolve after LITT. The mean TTR and OS were 12.2 and 38.1 months, respectively. TTR and OS varied significantly by lesion subtype (p < 0.001, log-rank analysis). A high-grade lesion was identified as the single factor linked to tumor recurrence. Age, high-grade lesion, preoperative lesion volume, and readmission within 30 days were identified as factors significantly associated with OS in the multivariable Cox regression analysis. EOA > 100% predicted longer OS in metastases and GBM by log-rank analysis.

CONCLUSIONS
LITT stands as a secure and feasible ablative treatment choice for intracranial lesions, potentially suitable for specific patient cases otherwise not amenable to surgical intervention. These findings further corroborate the safety of the procedure and its favorable outcomes, underscoring its potential significance in clinical practice.
Defining light transmission aggregometry cutoff values for clopidogrel and aspirin resistance in flow diversion treatment of intracranial aneurysms
Authors: Enriquez-Marulanda Alejandro , Filo Jean , Ramirez-Velandia Felipe , Fodor Thomas , Sconzo Daniel , Young Michael , Muram Sandeep , Shutran Max , Granstein Justin , Taussky Philipp , Ogilvy Christopher S. 
Published: June 2024

OBJECTIVE
Concern about thromboembolic events after flow diversion (FD) warrants dual antiplatelet therapy for 3 to 6 months. Platelet function tests are routinely performed prior to the procedure to detect clopidogrel responsiveness, as resistance is associated with CYP2C19 gene polymorphisms. This study aimed to identify optimal cutoff values in light transmission aggregometry (LTA) for clopidogrel and aspirin as predictive indicators of thromboembolic complications.

METHODS
The authors conducted a retrospective analysis of aneurysms treated with FD between 2013 and 2023 at a single academic institution. Patients with LTA data for adenosine diphosphate (ADP) and arachidonic acid (ARA) were included, excluding those with aborted procedures. Receiver operating characteristic curves were plotted for ADP and ARA assays to determine optimal cutoff values.

RESULTS
A total of 442 patients harboring 552 aneurysms treated in 485 procedures were selected for this analysis. Complete and near-complete aneurysm occlusion on the last radiological follow-up was achieved in 81.8% of aneurysms in a median last imaging follow-up of 13.9 months. A good functional outcome (modified Rankin Scale score ≤ 2) was achieved in 96.3% of patients on the last follow-up. Thromboembolic complications occurred in 4.9% of procedures, and intracranial hemorrhagic complications in 1.9%. For the ADP assay, a value ≥ 40% reached a sensitivity of 82.1% and a specificity of 42.9% with a positive likelihood ratio (LR) of 1.50. For the ARA assay, a value ≥ 13.5% reached a sensitivity of 82.1% and a specificity of 45.6% with a positive LR of 1.51.

CONCLUSIONS
This study analyzed the largest FD-treated cohort in which optimal LTA platelet function thresholds for clopidogrel were evaluated and is the first to assess LTA values for aspirin. The authors found that values ≥ 40% for clopidogrel and ≥ 13.5% for aspirin were optimal for predicting thromboembolic complications after FD in treating aneurysms.
Autologous rib graft for posterior cervical fusion in pediatric patients: efficacy and safety in the early postoperative period
Authors: Jackson Hudin , Snyder Rita , Lepard Jacob R. , Bauer David F. 
Published: June 2024

OBJECTIVE
The objective was to describe the indications, technique, and initial outcomes of autologous rib graft with recombinant human bone morphogenetic protein (rhBMP) in pediatric patients undergoing posterior cervical fusion.

METHODS
A retrospective study was performed of all pediatric patients who underwent autologous rib grafting with extra-small rhBMP-2 for posterior craniocervical or cervical arthrodesis at a single institution between May 2020 and July 2023. Patients with less than 3 months of postoperative follow-up and no postoperative CT data were excluded. Primary outcomes included presence of fusion on CT, 30-day perioperative complications, and rib harvest complications.

RESULTS
Twenty-eight sequential patients met inclusion criteria. Thirteen were male, 15 were female, and the average age was 9 years. There were no surgical site infections or instances of postoperative seroma or unplanned return to the operating room. All patients had solid fusion on postoperative CT at 3 months. The average follow-up was 14.5 months, with a range of 4 months to 3 years. There were no complications associated with the rib harvest, including no instances of harvest site pain, and all patient incisions healed well.

CONCLUSIONS
The authors’ preliminary results demonstrate that autologous rib graft with extra-small rhBMP-2 is an effective strategy to achieve a high rate of fusion in pediatric patients undergoing posterior instrumented craniocervical or cervical fusion. In this series, the authors found an acceptable safety profile, without seroma, surgical site infection, unplanned return to the operating room, or rib harvest complications.
Computed tomography assessment of robotic versus fluoroscopic implant accuracy in sacroiliac joint fusion
Authors: Harake Edward S. , Lee John H. , Zaki Mark M. , Joshi Rushikesh S. , Linzey Joseph R. , Patel Rakesh D. , Park Paul , Saadeh Yamaan S. 
Published: June 2024

OBJECTIVE
Computed tomography is considered the gold-standard imaging tool to evaluate spinal implant accuracy. However, there are no studies that evaluate the accuracy of robotic sacroiliac joint (SIJ) implant placement using CT to date. The aim of this study was to compare the accuracy of implant placement on CT between robotic and fluoroscopic navigation for SIJ fusion and the subsequent complications and clinical outcomes of suboptimally placed screws.

METHODS
A retrospective analysis of SIJ fusions utilizing either robotic or fluoroscopic guidance at a single institution was conducted from 2014 to 2023. Implant placement accuracy was evaluated on intra- or postoperative CT. Primary endpoints were SIJ screw placement accuracy and complications. Secondary endpoints were pain status at the first and second follow-ups and rates of 2-year revision surgery. Statistical analysis was performed using chi-square tests.

RESULTS
Sixty-nine patients who underwent 78 SIJ fusions were included, of which 63 were robotic and 15 were fluoroscopic. The mean age of the cohort at the time of surgery was 55.9 ± 14.2 years, and 35 patients (50.7%) were female. There were 135 robotically placed and 34 fluoroscopically placed implants. A significant difference was found in implant placement accuracy between robotic and fluoroscopic fusion (97.8% vs 76.5%, p < 0.001). When comparing optimal versus suboptimal implant placement, no difference was found in the presence of 30-day complications (p = 0.98). No intraoperative complications were present in this cohort. No difference was found in subjective pain status at the first (p = 0.69) and second (p = 0.45) follow-ups between optimal and suboptimal implant placement. No patients underwent 2-year revision surgery.

CONCLUSIONS
Use of robotic navigation was significantly more accurate than the use of fluoroscopic navigation for SIJ implant placement. Complications overall were low and not different between optimally and suboptimally placed implants. Suboptimally placed implants did not differ in degree of subjective pain improvement or rates of revision surgery postoperatively.
Evaluation of cervical spine clearance scores in children younger than 3 years with blunt trauma
Authors: Azad Tej D. , Jiang Kelly , Weber-Levine Carly , Lee Ryan P. , Jain Amit , Sponseller Paul , Groves Mari , Theodore Nicholas , Nasr Isam W. , Jackson Eric M. 
Published: June 2024

OBJECTIVE
The PEDSPINE I and PEDSPINE II scores were developed to determine when patients require advanced imaging to rule out cervical spine injury (CSI) in children younger than 3 years of age with blunt trauma. This study aimed to evaluate these scores in an institutional cohort.

METHODS
The authors identified patients younger than 3 years with blunt trauma who received cervical spine MRI from their institution’s prospective database from 2012 to 2015. Patient demographics, injury characteristics, and imaging were compared between patients with and without CSI using chi-square and Wilcoxon rank-sum tests.

RESULTS
Eighty-eight patients were identified, 8 (9%) of whom had CSI on MRI. The PEDSPINE I system had a higher sensitivity (50% vs 25%) and negative predictive value (93% vs 92%), whereas PEDSPINE II had a higher specificity (91% vs 65%) and positive predictive value (22% vs 13%). Patients with CSI missed by the scores had mild, radiologically significant ligamentous injuries detected on MRI. Both models would have recommended advanced imaging for the patient who required halo-vest fixation (risk profile: no CSI, 81.9%; ligamentous, 10.1%; osseous, 8.0%). PEDSPINE I would have prevented 52 (65%) of 80 uninjured patients from receiving advanced imaging, whereas PEDSPINE II would have prevented 73 (91%). Using PEDSPINE I, 10 uninjured patients (13%) could have avoided intubation for imaging. PEDSPINE II would not have spared any patients intubation.

CONCLUSIONS
Current cervical spine clearance algorithms are not sensitive or specific enough to determine the need for advanced imaging in children. However, these scores can be used as a reference in conjunction with physicians’ clinical impressions to reduce unnecessary imaging.
BAITUL MAAL PROSPERITY IN CIVIC ECONOMY AS A MANIFESTATION OF THE VOLUNTARISM FORMATION IN KASIH SAYANG VILLAGE LANGKAT REGENCY
Authors: Junaidi Junaidi , Jamaludin Jamaludin , Hodriani Hodriani , Laila Hapni , Ivanna Julia , Madiyoh Abdulhakim 
Published: June 2024

<p>This research aims to examine the concept of Baitul Maal in realizing prosperity in Kasih Sayang Village, which is based on Islamic principles and Pancasila values to foster a civic economy approach in daily life. The study also explores how the community of Kasih Sayang Village cultivates a sense of citizenship through voluntarism that contributes to social harmony and well-being. The research utilized a qualitative method with a phenomenological approach. Data collection techniques were observation, interviews, and documentation. The analysis employed interpretative phenomenological analysis with the assistance of the ATLAS.ti software for ease and innovation in research data analysis. Research findings reveal that Baitul Maal in Kasih Sayang Village serves as an economic center and an economic<br />design reflecting unity, collaboration, development, and empowerment. The role of Baitul Maal extends beyond economic aspects. It integrates Pancasila values, citizenship spirit, and sustainability to propel the community toward holistic development and empowerment. The community of Kasih Sayang Village is grounded in three voluntarism concepts: teodical (reliance on God), ethical (contributing based on goodwill), and psychological (internal drive). Integrating these concepts creates a harmonious environment in the village, where spiritual, moral, and psychological values unite to achieve shared prosperity. </p>
CONTRASTING THOUGHTS: INTERNALIZATION OF ISLAM WASATIYAH OF DAYAH ULAMA IN GROUNDING MODERATE ISLAM IN PESANTREN
Authors: Anzaikhan M. , Muarrif Muhammad Riza , Bahri Syamsul , Sufrizal Sufrizal , Umam Chatibul 
Published: June 2024

<p>This research explains the change of contrasting thoughts in pesantren (an Islamic boarding school), which is indicated as radical and terrorist in Aceh Tamiang. Ulama's thoughts and concepts of Pesantren Al-Hidayah influenced the changes after undergoing guidance from the government. This article is field research with a qualitative approach. A case study and phenomenological study were used as the methodology. The research results concluded that the internalization of Islam Wasathiyah at Pesantren Al-Hidayah contained seven themes, including Environmental Islam, Al-Musawat and AlTawazun (justice), AsSamahah (tolerance), Shura (deliberation), Islah and Ihsan (reconciling), Qudwah (role model), and Muthwathanah (nationalism).<br /><br /></p>
The study some changes biochemical parameters in patient’s renal failure in before and after haemodialysis program
Authors: Nahi Habbob Salam , A.H. Khalil Sajedha 
Published: June 2024

This study was designed to investigate changes in some biochemical parameters (urea, creatinine, sodium, potassium) at the end stage of renal disease (ESRD) patient on convenintial haemodialysis program.
The study was included collected of one hundred and thirteen (113) samples. Eighty-three (83) patients with end stage renal disease on haemodialysis program including (47) males and (36) females with a mean age of (43.3±18.0) years and range from (20-65) years. All the patients had been on dialysis twice per week for two hours each time. In addition, thirty from apparently healthy volunteers as control.
The subjects were fasted for twelve hours and the samples were drowning 30 minutes before haemodialysis and 30 minutes after haemodialysis.
This study showed highly significant differences in urea and creatinine concentrations before and after haemodialysis and when compared with control (before haemodialysis with control and after haemodialysis with control). The significant changes exist when the patients grouped according to gender (male and female) and age [(20-35), (36-50) and (51-65) years].
The electrolytes were varied in their changes. There was non-significant difference in sodium concentration except significant change in before and after haemodialysis when compared each with control; while potassium showed a highly significant changes except when pre dialysis compared to control and in the last two age groups (36-50) and (51-65) years in which there were no significant difference.
A Study of Boundedness in rectangular fuzzy n-normed spaces
Authors: Mohayman Ragheb Badr  , Mohammed Jassim Mohammed  
Published: June 2024

Various forms of boundedness in rectangular fuzzy n-normed linear spaces of type are examined in this work, where ∗ represents an arbitrary t-norm. Some of these highly general notions of boundedness have no counterpart in the traditional topological metrizable linear spaces. We list the properties of these bounded sets and conduct a comparative analysis of the various forms of boundedness. Among these are a number of ideas on the symmetrical characteristics of the objects under study that come from the classical context and are relevant to the issues of this magazine. We define their consequences and provide instances to show how different these notions are from one another.
Investigation of Saturable Absorber Length Effect on Characteristics of Passive Q-Switching and Stokes with Anti-Stokes Pulses Generated in Laser System of Nd:YVO4
Authors: Saad Dunya , Abdul-Kareem Mahdi Salih  , Asal Rasool 
Published: June 2024

The effect of the saturable absorbent material on the characteristics of a single laser pulse results from the passive Q-switching method, or two pulses. The first pulse is resulted from the passive Q-switching method and the other is resulted from Stokes pulse generated by the laser ray reaction with the Raman medium in the optical system. This study simulated this effect on the characteristics of three pulses (passive Q-switching pulse, Stokes pulse, and anti-Stokes pulse) simultaneously generated from one optical system . The optical system consists of Nd: YVO4, PbWO4, and Cr + 4: YAG as an effective medium, Raman medium, and saturable absorbent material, respectively. The modeling of the rate equations was used, and the Rung-Kutta-Fehelberg numerical method was used to solve the rate equations. The results show increased power of the pulses generated, requiring an increased length of the saturable absorber material used in the system. The results showed that at the shortest length used for the saturated absorbent material, the pulse duration and energy of the three generated pulses were PQS pulse (16.44ns, 1.39mJ), Stokes pulse (12.59ns, 1.148mJ) and anti-Stokes pulse (13.53ns, 1.59mJ), while at the longest length of the saturated absorbent material, the pulse duration and energy were PQS pulse (14.68ns, 1.50mJ), the Stokes pulse (11.41ns, 1.36mJ) and the anti-Stokes pulse (12.38ns, 1.86mJ).
Effect of Saturable Absorber Length on Characteristics of Dual Laser Pulses of Passive Q-Switched
Authors: A.Shadood Sara , Abdul-Kareem Mahdi Salih  , Asal Rasool 
Published: June 2024

The effect of saturable absorber material length on the characteristics of the dual passive Q-switching pulses generated from two wavelengths ( and ) instead of single wavelength was simulated. Numerical solution of our previous rate equations model using Rung-Kutta-Fahelberg method has been utilized in simulation. Nd+3 :YAG using as an active medium, and Cr+4:YAG as a saturable absorber material. The results showed that the Nd+3:YAG dual passive Q-switching generated or released at an advanced(earlier) time and characterized by short duration times, high energy and high power with the increasing in the value of . The passive Q-switching for , are released respectively at time 58ns, 60 ns approximately at , while released at time 34 ns, 36 ns respectively approximately at . The duration time of , pulses approximate to 16.8ns, 14.6 ns respectively at , while approximate to 10.8 ns ,9.2 ns respectively at .
Estimation of Hepcidin Role and some Biochemical Parameters in Patients with Beta- thalassemia in Thi-Qar Governorate/ Iraq
Authors: Majid Alyaa , Alyar Saliha , Almusawi Mohammed Yasir 
Published: June 2024

The β-thalassemias are a group of recessively inherited genetic disorders that cause varying amounts of hemoglobin production. The study's aim was to look at hepcidin, ferretin, iron, PCV, Hb, ALT, AST, and albumin levels. Serum hepcidin, ferretin, iron, PCV, Hb, ALT, AST, and albumin levels were determined in 55 patients with beta-thalassemia and 55 healthy individuals. The results demonstrated a substantial rise in serum concentrations of ferretin, iron, ALT and AST in the beta-thalassemia group as compared to the control group(p<0.001). There was also a significant decrease in the concentrations in the serum of hepcidin, packed cell volume, hemoglobin and albumin (p<0.001).
Penetas Telur ayam Otomatis dengan Metode Fuzzy Logic Control Dalam Upaya Meningkatkan Penetasan
Authors: Setyawan Adhitya , Yulianto  , Budi Edi Sulistio 
Published: June 2024

Salah satu usaha bagi petani yang bergerak di bidang peternakan adalah beternak ayam pedaging dan ayam petelur. Sudah banyak para peternak yang mempunyai alat untuk menetaskan telur ayam, tetapi alat tersebut masih berjalan manual dan adapula yang masih semi otomatis. Penggunaan alat penetasan secara manual atau semi otomatis akan menyebabkan suhu dan kelembaban kurang terkontrol sehingga produktivitas tetasan rendah. Untuk mempermudah para peternak menetaskan telur ayam tersebut, perlu direncanakan dan dibuat suatu mesin penetas dengan suhu dan kelembaban yang terkontrol secara presisi. Pengaturan suhu diatur pada rentang 35˚C - 40˚C dengan kelembaban 50%-60% dengan control fuzzy. Sistem yang telah dibuat dapat digunakan untuk menjaga kestabilan suhu telur ayam selama di dalam inkubator pada suhu 36˚C. Tujuan pembuatan alat penetas telur ini yaitu, mempermudah para peternak dalam proses pengembangbiakan hewan yang diternak serta mempercepat proses pengembangbiakan sehingga hasil ternak juga lebih banyak dalam jangka waktu yang singkat. Pada pembuatan alat ini penulis mengharapkan alat ini bisa menghasilkan produktivitas tetasan meningkat dibanding dengan cara konvensional.
Alcohol abuse may increase the risk of autoimmune connective tissue disease: a nationwide population-based cohort study
Authors: Chang Chi-Chen , Wang Chia-Ti , Shih Hong-Mo , Ho Chung-Han , Hsu Chien-Chin , Lin Hung-Jung , Chiu Yen-Wei , Huang Chien-Cheng 
Published: June 2024

ObjectivesAltered immune and inflammatory responses resulting from alcohol abuse have been implicated in increasing the risk of autoimmune connective tissue disease (ACTD). However, limited research has been conducted on this topic in the Asian population. Therefore, this study was undertaken to investigate and address this knowledge gap.MethodsUsing data from Taiwan’s National Health Insurance Research Database, we identified all patients with alcohol abuse between 2000 and 2017. We selected a comparison cohort without alcohol abuse, matching them in terms of age, sex, and index date at a 3:1 ratio. We collected information on common underlying comorbidities for analysis. Both cohorts were followed up until the diagnosis of ACTD or the end of 2018.ResultsA total of 57,154 patients with alcohol abuse and 171,462 patients without alcohol abuse were included in the study. The age and sex distributions were similar in both cohorts, with men accounting for 89.8% of the total. After adjusting for underlying comorbidities, patients with alcohol abuse had a higher risk of developing ACTD [adjusted hazard ratio (AHR): 1.12, 95% confidence interval (CI): 1.01–1.25]. The stratified analysis revealed that this increased risk was specific to the male population. Additionally, besides alcohol abuse, liver disease, renal disease, coronary artery disease, and chronic obstructive pulmonary disease were identified as independent predictors for ACTD.ConclusionThis study demonstrates that alcohol abuse increases the risk of developing ACTD in the Asian population, particularly among men. Therefore, it is important to implement alcohol cessation, especially in individuals with liver disease, renal disease, coronary artery disease, and chronic obstructive pulmonary disease.