bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical heterogeneity within the ALS‐FTD spectrum in a family with a homozygous optineurin mutation
Authors: Parvizi Tandis , Klotz Sigrid , Keritam Omar , Caliskan Haluk , Imhof Sophie , König Theresa , Haider Lukas , Traub‐Weidinger Tatjana , Wagner Matias , Brunet Theresa , Brugger Melanie , Zimprich Alexander , Rath Jakob , Stögmann Elisabeth , Gelpi Ellen , Cetin Hakan 
Published: May 2024

AbstractObjectiveMutations in the gene encoding for optineurin (OPTN) have been reported in the context of different neurodegenerative diseases including the amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) spectrum. Based on single case reports, neuropathological data in OPTN mutation carriers have revealed transactive response DNA‐binding protein 43 kDa (TDP‐43) pathology, in addition to accumulations of tau and alpha‐synuclein. Herein, we present two siblings from a consanguineous family with a homozygous frameshift mutation in the OPTN gene and different clinical presentations.MethodsBoth affected siblings underwent (i) clinical, (ii) neurophysiological, (iii) neuropsychological, (iv) radiological, and (v) laboratory examinations, and (vi) whole‐exome sequencing (WES). Postmortem histopathological examination was conducted in the index patient, who deceased at the age of 41.ResultsThe index patient developed rapidly progressing clinical features of upper and lower motor neuron dysfunction as well as apathy and cognitive deterioration at the age of 41. Autopsy revealed an ALS‐FTLD pattern associated with prominent neuronal and oligodendroglial TDP‐43 pathology, and an atypical limbic 4‐repeat tau pathology reminiscent of argyrophilic grain disease. The brother of the index patient exhibited behavioral changes and mnestic deficits at the age of 38 and was diagnosed with behavioral FTD 5 years later, without any evidence of motor neuron dysfunction. WES revealed a homozygous frameshift mutation in the OPTN gene in both siblings (NM_001008212.2: c.1078_1079del; p.Lys360ValfsTer18).InterpretationOPTN mutations can be associated with extensive TDP‐43 pathology and limbic‐predominant tauopathy and present with a heterogeneous clinical phenotype within the ALS‐FTD spectrum within the same family.
A Biomimetic Leaflet Scaffold for Aortic Valve Remodeling
Authors: De Jesus Morales Kenneth J. , Santosa Utari , Brazhkina Olga , Rajurkar Pranshu , Jo Hanjoong , Davis Michael E. 
Published: May 2024

AbstractHeart valve disease poses a significant clinical challenge, especially in pediatric populations, due to the inability of existing valve replacements to grow or respond biologically to their microenvironment. Tissue‐engineered heart valves (TEHVs) provide a solution by facilitating patient‐specific models for self‐repair and remodeling. In this study, a 3D‐bioprinted TEHV is designed to emulate the trilayer leaflet structure of an aortic valve. A cell‐laden hydrogel scaffold made from gelatin methacrylate and polyethylene glycol diacrylate (GelMA/PEGDA) incorporates valvular interstitial‐like (VIC‐like) cells, being reinforced with a layer of polycaprolactone (PCL). The composition of the hydrogel scaffold remains stable over 7 days, having increased mechanical strength compared to pure GelMA. The scaffold maintains VIC‐like cell function and promotes extracellular matrix (ECM) protein expression up to 14 days under two dynamic culture conditions: shear stress and stretching; replicating heart valve behavior within a more physiological‐like setting and suggesting remodeling potential via ECM synthesis. This TEHV offers a promising avenue for valve replacements, closely replicating the structural and functional attributes of a native aortic valve, leading to mechanical and biological integration through biomaterial–cellular interactions.
A Membrane‐Free Rechargeable Seawater Battery Unlocked by Lattice Engineering
Authors: Wen Wei , Geng Chao , Li Xinran , Li Hongpeng , Wu Jin‐Ming , Kobayashi Hisayoshi , Sun Tulai , Zhang Zhenyu , Chao Dongliang 
Published: May 2024

AbstractSeawater batteries that directly utilize natural seawater as electrolytes are ideal sustainable aqueous devices with high safety, exceedingly low cost, and environmental friendliness. However, the present seawater batteries are either primary batteries or rechargeable half‐seawater/half‐nonaqueous batteries because of the lack of suitable anode working in seawater. Here, a unique lattice engineering to unlock the electrochemically inert anatase TiO2 anode to be highly active for the reversible uptake of multiple cations (Na+, Mg2+, and Ca2+) in aqueous electrolytes is demonstrated. Density functional theory calculations further reveal the origin of the unprecedented charge storage behaviors, which can be attributed to the significant reduction of the cations diffusion barrier within the lattice, i.e., from 1.5 to 0.4 eV. As a result, the capacities of anatase TiO2 with 2.4% lattice expansion are ≈100 times higher than the routine one in natural seawater, and ≈200 times higher in aqueous Na+ electrolyte. The finding will significantly advance aqueous seawater energy storage devices closer to practical applications.
Harnessing Nanochaperone‐Mediated Autophagy for Selective Clearance of Pathogenic Tau Protein in Alzheimer's Disease
Authors: Xu Linlin , Wu Xiaohui , Zhao Shuyue , Hu Haodong , Wang Silei , Zhang Yongxin , Chen Jiajing , Zhang Xiaochen , Zhao Yu , Ma Rujiang , Huang Fan , Shi Linqi 
Published: May 2024

AbstractAccumulation of pathological tau is a hallmark of Alzheimer's disease (AD), which correlates more closely with cognitive impairment than does the amyloid‐β (Aβ) burden. Autophagy is a powerful process for the clearance of toxic proteins including aberrant tau. However, compromised autophagy is demonstrated in neurodegeneration including AD, and current autophagy inducers remain enormously challenging due to inability of restoring autophagy pathway and lack of targeting specificity. Here, pathogenic tau‐specific autophagy based on customized nanochaperone is developed for AD treatment. In this strategy, the nanochaperone can selectively bind to pathogenic tau and maintain tau homeostasis, thereby ensuring microtubule stability which is important for autophagy pathway. Meanwhile, the bound pathogenic tau can be sequestered in autophagosomes by in situ autophagy activation of nanochaperone. Consequently, autophagosomes wrapping with pathogenic tau are able to be trafficked along the stabilized microtubule to achieve successful fusion with lysosomes, resulting in the enhancement of autophagic flux and pathologic tau clearance. After treatment with this nanochaperone‐mediated autophagy strategy, the tau burden, neuron damages, and cognitive deficits of AD mice are significantly alleviated in the brain. Therefore, this work represents a promising candidate for AD‐targeted therapy and provides new insights into future design of anti‐neurodegeneration drugs.
A General Molecular Structural Design for Highly Efficient Photopyroptosis that can be Activated within 10 s Irradiation
Authors: Liu Qingsong , Yao Xianxian , Zhou Lulu , Wu Wenfeng , Cheng Jianshuo , Zhang Zexin , Li Zhongyu , Sun Hao , Jin Jian , Zhang Man , Wu Hongwei , Zhu Shihui , Yang Wuli , Zhu Liangliang 
Published: May 2024

AbstractPhotopyroptosis is an emerging research branch of photodynamic therapy (PDT), whereas there remains a lack of molecular structural principles to fabricate photosensitizers for triggering a highly efficient pyroptosis. Herein, a general and rational structural design principle to implement this hypothesis, is proposed. The principle relies on the clamping of cationic moieties (e.g., pyridinium, imidazolium) onto one photosensitive core to facilitate a considerable mitochondrial targeting (both of the inner and the outer membranes) of the molecules, thus maximizing the photogenerated reactive oxygen species (ROS) at the specific site to trigger the gasdermin E‐mediated pyroptosis. Through this design, the pyroptotic trigger can be achieved in a minimum of 10 s of irradiation with a substantially low light dosage (0.4 J cm⁻2), compared to relevant work reported (up to 60 J cm⁻2). Moreover, immunotherapy with high tumor inhibition efficiency is realized by applying the synthetic molecules alone. This structural paradigm is valuable for deepening the understanding of PDT (especially the mitochondrial‐targeted PDT) from the perspective of pyroptosis, toward the future development of the state‐of‐the‐art form of PDT.
Dual‐Step Redox Engineering of 2D CoNi‐Alloy Embedded B, N‐Doped Carbon Layers Toward Tunable Electromagnetic Wave Absorption and Light‐Weight Infrared Stealth Heat Insulation Devices
Authors: Huang Wenhuan , Song Ming , Wang Shun , Wang Bokun , Ma Jiachen , Liu Tong , Zhang Yanan , Kang Yifan , Che Renchao 
Published: May 2024

Abstract2D layered metallic graphite composites are promising electromagnetic wave absorption materials (EWAMs) for their combined properties of abundant interlayer free spaces, rich metallic polarized sites, and high conductivity, but the controllable synthesis remains rather challenging. Herein, a dual‐step redox engineering strategy is developed by employing cobalt boron imidazolate framework (Co‐BIF) to construct 2D CoNi‐alloy embedded B, N‐doped carbon layers (2D‐CNC) as a promising EWAM. In the first step, a chemical etching oxidation process on Co‐BIF is used to obtain an optimized 2D‐CoNi‐layered double hydroxide (2D‐CoNi‐LDH) intermediate and in the second, high‐temperature calcination reduction is implemented to modify graphitization of the degree of the 2D‐CNC. The obtained sample delivers superior reflection loss (RLmin) of −60.1 dB and wide effective absorption bandwidth (EAB) of 6.24 GHz. The synergy mechanisms of interfacial/dipole polarization and magnetic coupling are in‐depth evidenced by the hologram and Lorentz electron microscopy, revealing its significant contribution on multireflection and impedance matching. Further theoretical evaluation by COMSOL simulation in different fields based on the dynamic loss process toward the test ring reveals the in situ EW attenuation process. This work presents a strategy to develop multifunctional light‐weight infrared stealthy aerogel with superior pressure‐resistant, anti‐corrosion, and heat‐insulating properties for future applications.
High‐Efficiency Single‐Photon Upconversion Photoluminescence of Perovskite Quantum Dots via Intragap State Regulation
Authors: Gao Jie , Sun Yang , Wang Xinli , Gao Xiaowen , Li Qi , Wang Yi , Ai Xi‐Cheng , Xu Dongsheng , Zhang Jian‐Ping 
Published: May 2024

AbstractLead halide perovskite quantum dots (PQDs) have shown remarkable single‐photon upconversion photoluminescence (SPUC‐PL) bringing them a brilliant perspective as the active media for biological imaging, optiag, and upconversion photovoltaics. However, the mechanism of SPUC in PQDs is still in dispute, and the specific strategy for optimizing PQDs toward a higher SPUC performance has yet to be established, which impedes the application of PQDs‐based SPUC‐PL in practice. In this work it is revealed that the PL quantum yield is declined by surface trap states, while the SPUC efficiency is promoted by Urbach tail states. These two types of intragap states can be chemically manipulated by engineering the surface ligand and the growth kinetics of perovskite nanocrystals, bringing on the improvement of light emission efficiency and the promotion of subgap low‐energy photon absorption, respectively. As a proof of concept, utilizing the synergistic effect of the proposed chemical manipulation method, the SPUC‐PL efficiency of PQDs is boosted by more than 40%, which gives rise to a spectral window of optical refrigeration gain as broad as ≈130 meV.
Förster Resonance Energy Transfer Control by Means of an Optical Force
Authors: Nagai Tatsuya , Jie Lu , Teranishi Satsuki , Yuyama Ken‐ichi , Shoji Tatsuya , Matsumura Yuriko , Tsuboi Yasuyuki 
Published: May 2024

AbstractFörster resonance energy transfer (FRET) is ubiquitous in optical processes in the natural world. A methodology is proposed that uses an optical force to control its efficiency without contact in an aqueous solution of a thermo‐responsive polymer, polyvinyl methyl ether (PVME). Focusing irradiation of a near infrared laser beam into the solution results in the formation and trapping of a single polymer droplet. The polymer concentration in the droplet is controllable by changing the optical force from the laser light is shown. The polarity inside the droplet decreases with increasing the optical force. When small amounts of dye molecules, D (energy donor) and A (energy accepter), are dissolved in the polymer solution, D and A are absorbed (extracted) into the droplet. The concentrations of D and A are controllable by the optical force. Based on this mechanism, FRET between D and A is induced successfully, and can control the FRET efficiency. Finally, the modulation of fluorescence color of the droplet from blue, green, yellow, to an orange color is demosntrated simply by changing the optical force. The concept and technique are unique and will open a new channel to develop droplet chemistry and photochemistry.
Non‐Volatile and Gate‐Controlled Multistate Photovoltaic Response in WSe2/h‐BN/Graphene Semi‐Floating Gate Field‐Effect Transistors
Authors: Fu Jingjing , Shi Hangrui , Cai Miao , Xu Mengjian , Fu Yuxin , Zhang Jinhua , Guo Xuguang , Wang Fang , Zhu Yiming , Rogalski Antoni 
Published: May 2024

AbstractSemi‐floating gate field‐effect transistors (SFG‐FETs) based on 2D materials have received much attention due to their unique optoelectronic characteristics, potential applications in near‐memory computing and constructing sensing‐memory‐processing units. Here, the non‐volatile and gate‐controlled multistate photovoltaic response of a WSe2/h‐BN/graphene SFG‐FET is investigated both in experimental and theoretical aspects. Due to the ambipolar carrier transport of WSe2 channel, both electrons and holes can be stored in the graphene floating gate layer, which results in two evident memory windows on the round sweep transfer characteristic curve. Different charge‐stored states of the SFG layer enable the channel to form a lateral junction that can be adjusted by the gate voltage, which leads to the gate‐controlled multistate photovoltaic response. A theoretical model is implemented to explain the memory and the multistate photovoltaic response behaviors in a quasi‐quantitative level. The relationship between the charge‐stored states in the SFG and the photo‐response, as well as its dependence on the gate voltage are systematically analyzed. These research results provide a reliable way for realizing high‐performance multi‐functional photodetectors based on SFG‐FETs and for thorough understanding the complicated optoelectronic behaviors of SFG‐FETs.
Lewis Acid‐Promoted Domino Processes for the Synthesis of Homoallylic Amines, Quinolines and Tetrahydroquinolines
Authors: Vishwakarma Rahul , Vodnala Nagaraju , Musib Dulal , Singh Sanjay , Kumar Hazra Chinmoy 
Published: May 2024

AbstractHerein, the synthesis of homoallylic amines, quinolines, and tetrahydroquinolines has been demonstrated. The domino one‐pot multi‐component approach has been accomplished using Lewis acid‐catalyzed conditions. A useful scaffold construction strategy can be achieved by controlling the electronic effect of aniline rather than relying on reaction conditions. The described method applies to a wide variety of substrates embedded with diverse functional groups and can be extended toward the synthesis of natural products. Suitable control experiments, real‐time NMR studies, and DFT calculations have validated the reported process. The protocol outlines a strategy for synthesizing homoallylic amines and quinolines, controlled by the electronic properties of anilines.
Accurate Description of Coulombic Interactions in Organic Field‐Effect Transistors Enabled by Efficient 3D Poisson's Equation Solver with Mixed Boundary Conditions
Authors: Han Ying , Geng Yubo , Liu Lijun , Li Haoyuan 
Published: May 2024

AbstractThe rational development of organic electronic devices can greatly benefit from a molecular‐level description, where an accurate description of the Coulombic interactions among charge carriers holds paramount importance. However, the molecular‐level organic field‐effect transistor (OFET) simulations do not fully include the short‐range charge‐carrier Coulombic interactions, thus limiting their accuracy. Here, an efficient solution is demonstrated to the 3D Poisson's equation with mixed boundary conditions, optimized for integration into the simulations of organic electronic devices. It leverages the finite difference method for discretization, the Krylov subspace iterative methods for solving the linear system, the algebraic multigrid algorithm for preconditioning, and OpenMP and CUDA parallelization for acceleration. For the organic field‐effect transistors of micrometer sizes or smaller dimensions, obtaining the electric potential within the device takes less than 0.1 s, which is sufficiently efficient for molecular‐level modeling. As a result, both short‐ and long‐range electrostatic interactions are successfully incorporated in the molecular‐level modeling of OFET devices. This integration significantly enhances the robustness of OFET modeling for future applications.
High Spatiotemporal Resolution Radial Encoding Single‐Vessel fMRI
Authors: Jiang Yuanyuan , Pais‐Roldán Patricia , Pohmann Rolf , Yu Xin 
Published: May 2024

AbstractHigh‐field preclinical functional MRI (fMRI) is enabled the high spatial resolution mapping of vessel‐specific hemodynamic responses, that is single‐vessel fMRI. In contrast to investigating the neuronal sources of the fMRI signal, single‐vessel fMRI focuses on elucidating its vascular origin, which can be readily implemented to identify vascular changes relevant to vascular dementia or cognitive impairment. However, the limited spatial and temporal resolution of fMRI is hindered hemodynamic mapping of intracortical microvessels. Here, the radial encoding MRI scheme is implemented to measure BOLD signals of individual vessels penetrating the rat somatosensory cortex. Radial encoding MRI is employed to map cortical activation with a focal field of view (FOV), allowing vessel‐specific functional mapping with 50 × 50 µm2 in‐plane resolution at a 1 to 2 Hz sampling rate. Besides detecting refined hemodynamic responses of intracortical micro‐venules, the radial encoding‐based single‐vessel fMRI enables the distinction of fMRI signals from vessel and peri‐vessel voxels due to the different contribution of intravascular and extravascular effects.
Inter‐prefectural regional disparities in gastric cancer surgery: A Japanese nationwide population‐based cohort study from 2014 to 2019
Authors: Kido Masamitsu , Shoda Katsutoshi , Yan Luying , Ikoma Kazuya , Ichikawa Daisuke 
Published: May 2024

AbstractAimThis study aimed to investigate the regional disparities in gastric cancer surgery in Japan.MethodsThe annual incidence of gastric cancer and number of gastrectomies, board‐certified surgeons in gastroenterology by the Japanese Society of Gastroenterological Surgery, and board‐certified surgeons by the Japan Society for Endoscopic Surgery were evaluated by prefecture in Japan during 2014–2019. Medium‐sized regional disparities were assessed using the Gini coefficient. Gastrectomies were further broken down by site (distal; proximal; total) and approach (open vs laparoscopic). Moreover, we compared the urban and rural regional disparities in all study variables.ResultsThe annual national average incidence of gastric cancer was 127 466 and the number of gastrectomies was 49 128. Gini coefficients for almost all variables, except for board‐certified surgeons by the Japan Society of Endoscopic Surgery, were <0.2, indicating low inequality. The incidence of gastric cancer, the number of gastrectomies, and the aging rate were significantly higher in rural prefectures than in urban prefectures.ConclusionInter‐prefectural regional disparities in gastric cancer surgery were generally small; however, both the incidence of gastric cancer and number of gastrectomies were higher in rural prefectures, where the aging rate was also increased. This study provides an overview of the landscape of gastric cancer care in Japan.
Elaborately engineered Au(I)‐based AIEgens: Robust and broad‐spectrum elimination abilities toward drug‐resistant bacteria
Authors: Deng Shuangling , Peng Zhen , Zhou Fang , Zhong Guanqing , Cai Zhen , Tang Xiaodong , Xu Changhuo , Zheng Lei , Tang Ben Zhong , Zhang Jing 
Published: May 2024

AbstractAntimicrobial resistance (AMR) remains an urgent and formidable challenge to global public health. Developing new medicines or alternative therapies to address AMR is imperative. Herein, we rationally designed and synthesized a series of Au(I)‐based aggregation‐induced emission luminogens (AIEgens) to combat drug‐resistant bacterial infections. Through systematic screening, we identified an optimal AIEgen, called complex 5, which can rapidly discriminate between gram‐positive (G+) and gram‐negative bacteria (G−) bacteria, and exert robust and broad‐spectrum antimicrobial potency against diverse drug‐resistant bacterial strains, including those intractable to treat in clinic. Furthermore, extensive testing against a variety of clinical drug‐resistant isolates, coupled with the successful treatment of methicillin‐resistant Staphylococcus aureus‐infected skin wounds unequivocally validates the high efficiency and broad‐spectrum activity of complex 5. Therefore, complex 5 emerges as a promising candidate for combating drug‐resistant bacterial infections in clinic, and this work provides inspiration for developing new solutions to address the escalating global challenge of AMR.
A blueprint for a new commercial driving epidemiology: An emerging paradigm grounded in integrative exposome and network epistemologies
Authors: Apostolopoulos Yorghos , Sönmez Sevil , Thiese Matthew S. , Olufemi Mubo , Gallos Lazaros K. 
Published: May 2024

AbstractExcess health and safety risks of commercial drivers are largely determined by, embedded in, or operate as complex, dynamic, and randomly determined systems with interacting parts. Yet, prevailing epidemiology is entrenched in narrow, deterministic, and static exposure‐response frameworks along with ensuing inadequate data and limiting methods, thereby perpetuating an incomplete understanding of commercial drivers' health and safety risks. This paper is grounded in our ongoing research that conceptualizes health and safety challenges of working people as multilayered “wholes” of interacting work and nonwork factors, exemplified by complex‐systems epistemologies. Building upon and expanding these assumptions, herein we: (a) discuss how insights from integrative exposome and network‐science‐based frameworks can enhance our understanding of commercial drivers' chronic disease and injury burden; (b) introduce the “working life exposome of commercial driving” (WLE‐CD)—an array of multifactorial and interdependent work and nonwork exposures and associated biological responses that concurrently or sequentially impact commercial drivers' health and safety during and beyond their work tenure; (c) conceptualize commercial drivers' health and safety risks as multilayered networks centered on the WLE‐CD and network relational patterns and topological properties—that is, arrangement, connections, and relationships among network components—that largely govern risk dynamics; and (d) elucidate how integrative exposome and network‐science‐based innovations can contribute to a more comprehensive understanding of commercial drivers' chronic disease and injury risk dynamics. Development, validation, and proliferation of this emerging discourse can move commercial driving epidemiology to the frontier of science with implications for policy, action, other working populations, and population health at large.