bluuebunny/crossref_metadata_2025_split huggingface dataset:
About the Peak Age of Information in a Single-Channel Transmission Group Modeled by the $PH/PH/1/r/LCFS$ System with Inversion Discipline, Interruption Maintenance and Re-service of Applications
Authors: Гайдамака Юлия Васильевна , Матюшенко Сергей Иванович , Самуйлов Константин Евгеньевич 
Published: April 2024

Данная статья продолжает цикл работ авторов, посвященных проблеме возраста информации (Age of Information, AoI) - метрики, используемой в информационных системах для количественной оценки «свежести» информации, доставляемой в центр управления от периферийных источников. В работе рассматривается двухузловая группа передачи информации, состоящая из узла-отправителя, узла-получателя и канала связи между ними. Процесс передачи информации моделируется посредством однолинейной системы обслуживания конечной емкости с распределениями фазового типа, которая в обозначениях Кендалла кодируется как $PH/PH/1/r$. При этом учитываются особые условия передачи, состоящие в том, что поступающий в систему пакет, минуя очередь, сразу отправляется на передачу, захватывая канал у предыдущего пакета, если тот не завершил передачу. Пакет, передача которого была прервана, перемещается на первое место в очереди и после освобождения канала заново осуществляет попытку передачи. Для данной системы получено выражение для преобразования Лапласа-Стилтьеса стационарной функции распределения пикового возраста информации и его среднего значения. Проведено численное исследование зависимости пикового возраста информации от загрузки системы. Корректность аналитических результатов проверена путем их сравнения с результатами имитационного моделирования.
This article continues the author's cycle of works devoted to the problem of the Age of Information (AoI), a metric used in information systems to quantify the ``freshness'' of information delivered to the control center from peripheral sources. The paper considers a two-node information transmission group consisting of a sender node, a recipient node and a communication channel between them. The information transfer process is modeled by means of a single-line finite capacity queuing system with phase-type distributions, which in Kendall's notation is encoded as $PH/PH/1/r$. This takes into account the special requirements of the transmission protocol, which consist in the fact that a packet entering the system, bypassing the queue, is immediately sent for transmission, capturing the channel from the previous packet if it has not completed transmission. The packet whose transmission was interrupted is moved to the first place in the queue and, after the channel is released, attempts transmission again. For this system, an expression is obtained for the Laplace-Stieltjes transformation of the stationary distribution function of the peak age of information and its average value. A numerical study of the dependence of the peak age of information on the system load was carried out. The correctness of the analytical results was verified by comparing them with the results of simulation modeling.
FINANCIAL ANALYSIS AND VALUATION OF SELECTED UK LISTED COMPANY: A CASE STUDY
Authors: Obadire Ayodeji Michael , Omotesho Akindele Babatunde 
Published: April 2024

Objective: The objective of this study is to investigate the financial analysis and valuation of UK listed companies, with the aim of gaining insight into the financial performance and operational position of Hill and Smith Plc and other key players in the industry.

Theoretical Framework: In this study, the main concepts and theories that underpin the research include the irrelevance theory, trade off theory, pecking order theory and market timing theory. These theories explain the underlying factors that determine the financing and valuation choices of listed firms.

Method: The study adopted the net assets valuation, dividend discount model, free cashflows, earnings model, comparative companies, and comparative transactions valuation methodologies. The study adopted Hill and Smith Plc as a case study, extracting relevant data from its annual financial records.

Results and Discussion: The study revealed a +4.17% abnormal return, suggesting an exceptional performance. It compared financial positions with peers like Morgan Advanced Materials and Keller Group, employing multiple valuation methods. The earnings model indicated a share price of £14.1, suggesting a potential overvaluation in the stock market at £10.0 per share.

Research Implications: The practical and theoretical implications of this research are discussed, providing insights into how the results can be applied or influence practices in the field of corporate finance and valuation. These implications impact various stakeholders such as the researched firms, investors, and academia.

Originality/Value: This study contributes to the literature by highlighting the valuation methodologies employed in the study, emphasisng the importance of accurate valuation techniques in informing investment decisions.
EVALUATION OF THE BIOSORPTION OF Mn²⁺ AND Zn²⁺ BY PASSION FRUIT PEEL: STUDY OF DOSAGE AND CONTACT TIME
Authors: Viana Jéssica Hellen Chaves , Oliveira Jorge Diniz de , Sousa Helayne Santos de 
Published: April 2024

Objective: The objective of this study is to investigate he effectiveness of Mn2+ and Zn2+ biosorption by passion fruit peel as a sustainable and economically viable alternative to the biosorption process.

Method: The methodology adopted for this research comprises the characterization of the biomass and batch tests. Tests were carried out with different masses of biomass in standard solutions of the metals investigated. The biosorption capacity of the biomass and the removal efficiency were calculated based on the differences in concentration of the metal ions.

Results and Discussion: The results obtained revealed that the biomass showed high efficiency (close to 100%) for both cations. The contact time of 30 minutes was sufficient to reach equilibrium in the biosorption capacity of the metals, indicating the speed and effectiveness of the process.

Research Implications: The practical and theoretical implications of this research provide valuable information on the application of passion fruit peel as a biosorbent in the removal of potentially toxic metals from contaminated wastewater. These results may influence practices in the field of environmental remediation and environmental engineering, as well as in agro-industrial waste management.

Originality/Value: This study contributes to the literature by highlighting the originality of using passion fruit peel in natura as a biosorbent, presenting an innovative and sustainable approach to the remediation of contaminated effluents. The high efficiency of ion removal with low biomass dosages and short contact times adds knowledge to the field of biosorption using agro-industrial waste.
Menurunkan intensitas nyeri pemasangan arteriovena fistula pada pasien hemodialisis menggunakanteknik valsava maneuver
Authors: Suramadhan Suramadhan , Khoiriyah Khoiriyah , Sukraeny Nury , Armiyati Yunie 
Published: April 2024

Hemodialisis (HD) adalah pilihan utama dalam perawatan pada pasien penyakit ginjal kronis (PGK). Sejak menjalani HD pasien biasanya mengalami dua kanulasi di fistula mereka dua kali per minggu dan mengalami nyeri jarum setidaknya 192 kali setahun. Nyeri pada pemasangan arteriovena fistula (AVF) merupakan sumber ketidaknyamanan yang dirasakan pasa pasien dalam menjalankan perawatan kesehatan. Tujuan penulisan ini adalah untuk mengetahui penurunan intensitas nyeri pemasangan arteriovena fistula pada pasien hemodialisis menggunakan teknik valsava meneuver. Jenis studi kasus ini adalah analisis deskriptif dengan metode singlecase . Subyek dalam studi kasus ini sebanyak 1 pasien dengan mengukur intensitas nyeri sebelum dan sesudah dilakukan valsava meneuver pada duakali periode hemodialisis dengan menggunakan instrumen numerical pain rating scale. Nyeri yang dialami subyek studi kasus sebelum tindakan valsava meneuver berada diskala 6 sedangkan nyeri yang dirasakan setelah tindakan valsava meneuver berada diskala 4. Valsava meneuver yang dilakukan dapat menurunkan intensitas nyeri pemasangan AVF pada pasien yang menjalani hemodialisis. Valsava meneuver dapat diterapkan pada pasien yang menjalani hemodialisis sebagai tindakan nonfarmakologis untuk menurunkan intensitas nyeri pemasangan AVF.
Penerapan terapi musik untuk mengurangi halusinasi pendengaran pada pasien dengan skizofrenia
Authors: Erlanti Silvi , Suerni Titik 
Published: April 2024

Halusinasi merupakan salah satu gejala dari gangguan persepsi sensori yang dapat dialami oleh penderita gangguan jiwa. Perubahan perilaku yang dapat muncul pada penderita halusinasi seperti tidak mampu membedakan keadaan nyata dan tidak nyataketakutan, khawatir, gelisah, bingung, perasaan tidak nyaman, kurang diperhatikan orang dan tidak mampu mengambil keputusan. Gangguan halusinasi dapat di atasi dengan terapi non farmakologi salah astunya yaitu terapi musik karen tidak dapat menimbulkan efek samping seperti obat-obatan, salah satu terapi non farmakologi yang lebih efektif adalah mendengarkan musik, terapi musik ini dilakukan selama 5 hari berturut-turut. Tujuan dari aplikasi ini adalah memberikan rasa tenang, membantu mengendalikan emosi serta menyembuhkan gangguan psikologi. Metode yang digunakan pada study kasus ini adalah dengan pendekatan asuhan keperawatan berupa pengkajian, merumuskan masalah, perencanaan, melakukan tindakan, dan evaluasi. Pendekatan pengukuran yang dipergunakan pre dan post menggunakan AHRS (Audiotory Hallucinations Rating Scale). Proses ini dilakukan selama 5 hari berturut-turut selama pagi dan sore hari selama 10-15 menit yang dilakukan pada 2 responden. Hasil evaluasi terjadi pasien mengalami penurunan dan gejala setelah dilakukan terapi musik yang diterapkan oleh penulis. Penerapan terapi musik mampu terbukti menurunkan tanda gejala halusinasi pendengaran pasien.
Interdialityc exercise menurunkan interdialityc weight gain pada pasien hemodialisis
Authors: Chasanah Cahyaningrum , Lazuardi Nugroho , Armiyati Yunie , Sarinti Sarinti 
Published: April 2024

Peningkatan berat badan antar sesi dialisis atau yang dikenal interdialytic weight gain (IDWG) dapat menyebabkan komplikasi intradialisis. Komplikasi yang terjadi seperti hipotensi dan gangguan pernafasan tentu dapat mengancam nyawa. Latihan fisik/interdialytic exercise dapat menurunkan IDWG dan mengontrol berat badan, sehingga tujuan karya ilmiah ini adalah interdialytic exercise menurunkan interdialytic weight gain pasien Hemodialisis di RSUP Dr. Kariadi Semarang. Desain studi kasus pada karya ilmiah akhir Ners ini adalah studi kasus multiple case dengan mengaplikasikan intervensi interdialytic exercise pada pasien HD di RSUP Dr. Kariadi Semarang sebanyak 5 subjek. Latihan dilakukan 2 kali dalam setiap sesi dengan durasi latihan 20 menit dan konsisten sampai dengan 4 sesi. Evaluasi dilakukan dengan mengukur kenaikan berat badan dengan indikator batas kenaikan tidak lebih dari 3%. Terdapat penurunan IDWG dari pre sesi 4,79% menjadi 0,15% di akhir sesi. Interdialityc exercise menurunkan IDWG pasien Hemodialisis di RSUP Dr. Kariadi Semarang dan diharapkan kegiatan tersebut dapat dijadikan sebagai SOP untuk menunjang pelayanan keperawatan.
Age- and Sex-Related Reference Intervals of Prothrombin Time and Activated Partial Thromboplastin Time
Authors: Appiah Samuel K. , Nkansah Charles , Mensah Kofi , Osei-Boakye Felix , Serwaa Dorcas , Bani Simon B. , Abbam Gabriel , Daud Samira , Lardi Claudia S. , Oppong-Yeboah Emmanuel , Derigubah Charles A. , Kawuribi Vincent 
Published: April 2024

Background: Due to the differences in reference intervals (RIs) for clinical parameters between geographical regions, each laboratory needs to establish its own RIs to aid in effective clinical diagnosis and management. This study developed age- and sex-specific RIs for prothrombin time (PT) and activated partial thromboplastin time (aPTT) among apparently healthy adults in Tamale, Ghana. Methods: This cross-sectional study recruited 206 apparently healthy individuals, aged 18-46 and residing in Tamale, Northern Region of Ghana. The PT and aPTT were determined using the HumaClot Duo Plus semi-automated coagulation analyzer. The data were analyzed using SPSS version 26. The RIs for PT and aPTT were established at 2.5th-97.5th percentiles. Results: The RIs for PT and aPTT were 10.2-13.37 seconds and 20.41–35.28 seconds, respectively. Females had relatively wider PT RI values than their male counterparts [(9.91–13.39) vs. (10.10–13.37) seconds]. Conversely, males showed relatively wider RIs for aPTT as compared to the female population [(19.86–35.47) vs. (21.40–35.20) seconds]. Adults between the ages of 31-46 years had the widest PT RIs (10.10–13.55) seconds, while the 18-20 years age group had the lowest range (10.10–12.85) seconds. For aPTT, individuals aged 18 -20 years had relatively wider RIs of 19.50–35.25 seconds than the rest of the age groups. A weak positive correlation was observed between PT and age (r =0.166, p=0.017), while aPTT showed a weak inverse correlation with age (r= -0.203, p=0.003). Conclusion: Relatively wider RIs for PT (10.02–13.37 seconds) and aPTT (20.41–35.28 seconds) were found among the population in Northern Ghana. PT correlated positively with age, while aPTT inversely correlated with age. Females had relatively wider PT-RI values than their male counterparts. Conversely, males showed relatively wider RIs for aPTT than the female group. Doi: 10.28991/SciMedJ-2023-05-03-01 Full Text: PDF
A Case Study of the Treatment Strategies Employed to Cure a COVID-19 Patient with Multiple Infections Successfully
Authors: Abniki Reza , Pourdad Arezoo , Shirani Kiana , Mansury Davood 
Published: April 2024

The COVID-19 pandemic has given rise to new clinical challenges in healthcare settings. One of these challenges includes a heightened risk of secondary invasive bacterial and fungal infections, which have been associated with a notable mortality rate. We report a fatal case of a COVID-19 patient with two bacterial and one fungal infection successfully cured. A woman went to the hospital with fatigue, cough, chest and abdominal pain, nausea, and vomiting symptoms. She tested positive for COVID-19 and had underlying health conditions. She had a bacterial infection called Klebsiella Pneumoniae. The bacteria were resistant to many antibiotics, but colistin was effective. After 20 days in the ICU, she developed a fungal and Enterococcus faecalis(which was a Vancomycin-Resistant Enterococcus (VRE)) infection. The second bacteria were treated with linezolid. After 35 days in the hospital, she was discharged with no signs of infection. It is crucial to include proper bacterial screening and treatment when addressing COVID-19. Doi: 10.28991/SciMedJ-2023-05-03-02 Full Text: PDF
Methicillin Resistant Staphylococcus Aureus Colonization among HIV Patients
Authors: Igwe J. C. , Nkom P. J. , Durowaiye M. T. , Obajuluwa A. F. , Parom S. K. 
Published: April 2024

Introduction: Methicillin-resistant S. aureus is known to have a significant negative impact on both immunocompetent and immunocompromised individuals (HIV patients). Aim: This study evaluated the antibiotic susceptibility profile of MRSA staphylococcus aureus isolated from HIV patients attending Barau Dikko Teaching Hospital, Kaduna. Methods: Using sterile wet swabs, within the period of 3 months (January– March 2020), a total of 180 samples were collected from the skin, ear, and nasal cavities of 60 HIV patients who gave their consent to be part of the survey, and S. aureus was isolated. Isolation, bacterial characterization, and antimicrobial susceptibility tests were carried out using the methods described by Chesbrough and Kirby-Bauer, respectively. Results: The bacterial isolation rate was 76.7% (138/180) in the samples collected, with 56.5% (78) been Gram positive. The incidences of S. aureus and MRSA were 12.8% and 8.6%, respectively. From the sample sources, the distribution of S. aureus was more in the nostrils, followed by the skin and ear swabs. Resistance was observed against imipenem (86.9%), vancomycin (65.3%), tetracycline (65.3%), and erythromycin (60.9%), while susceptible to ciprofloxacin (60.9%), streptomycin (43.5%), and gentamycin (52.2%). A high percentage (91.3%) of S. aureus were multidrug-resistant and had MARI > 0.2. Conclusion: This study established that high-resistant S. aureus with a possible MRSA gene could be responsible for frequent staphylococcus-associated infections and resistance to treatment among HIV patients in Kaduna, Nigeria. Doi: 10.28991/SciMedJ-2023-05-03-03 Full Text: PDF
Association of cardiac mechanical dyssynchrony indices with data of dynamic single-photon emission computed tomography of the myocardium: the role of the time interval between the stress test and recording
Authors: Shipulin V. V. , Gonchikova E. V. , Polikarpov S. A. , Mochula A. V. 
Published: April 2024

Introduction. According to ECG-synchronized myocardial perfusion imaging (MPI) mechanical dyssynchrony (MD) is a sensitive marker of impaired myocardial perfusion. However, its direct comparison with indicators of myocardial blood flow reserve (MFR) according to single-photon emission computed tomography (SPECT) was not carried out. Traditional MPI protocols imply a long gap between stress test and image acquisition, during which stress-induced changes may pass. It is potentially possible to reduce the time interval down to 5 minutes.Aim: To investigate the relationship between early and delayed MD indices and the data of MFR by means of SPECT.Material and Methods. The study included 20 patients with suspected coronary heart disease, preserved left ventricular ejection fraction (> 55%) and without obstructive coronary artery lesions (< 50%) according to multislice computed coronary angiography. All patients underwent dynamic SPECT (dSPECT) according to a two-day rest/stress protocol. Gated MPI was performed 60 minutes after radiopharmaceutical administration. Myocardial blood flow and reserve, as well as phase histogram standard deviation (PSD, degree) and phase histogram bandwidth (HBW, degree) from 5 minutes after radiopharmaceutical administration were obtained from the dSPECT data by postprocessing. Perfusion data as well as MD indices (PSD, HBW) were obtained from delayed images. Based on dSPECT data, patients were divided into 2 groups: with preserved (MFR ≥ 2.0) and reduced (MFR < 2.0) myocardial blood flow reserve.Results. Correlation analysis showed that MD indices on stress test in early scan had a stronger association with MFR (PSD ρ = –0.68, p < 0.001; HBW ρ = –0.68, p = 0.001) compared to those in delayed scan (PSD ρ = –0.38, p = 0.019; HBW ρ = –0.44, p = 0.005). According to multivariate regression analysis, PSD on stress test at early scan was the only independent predictor of reduced MFR (OR 1.29 (1.1; 1.53)). Stress PSD > 22° obtained at early scanning had a sensitivity of 81% and specificity of 87% (AUC = 0.86, p < 0.001) in predicting of reduced MFR.Conclusion. Left ventricular mechanical dyssynchrony indices obtained by early post-stress gated MPI have a stronger association with myocardial blood flow reserve indices.
Production performance of Seurukan fish (Osteochilus sp.) with high density in recirculating system
Authors: Diansyah Sufal , Febrina Citra Dina , Islama Dini , Samsuli Said 
Published: April 2024

One of the local fish (native species) that is popular with the public and has quite good market prospects in Aceh is the seurukan fish (Osteochilus sp.). Seurukan fish cultivation technology with a recirculation system needs to be developed so that its potential can be utilized optimally. This research aims to evaluate production performance and determine the optimal stocking density for rearing seurukan fish (Osteochilus sp.) in a recirculation system. This research was conducted by experimental method. The experimental design used was a completely randomized design (CRD) with three treatments of stocking density and each treatment was repeated four times. The treatments are P1 (5 fish/m2), P2 (10 fish/m2), and P3 (15 fish/m2). The rearing period for Seurukan fish lasts for 50 days. The parameters tested during the research included biological parameters consisting of survival, absolute growth rate, feed conversion ratio, weight diversity coefficient, and water quality parameters including temperature, pH and dissolved oxygen. The results showed that the seurukan fish reared at different stocking densities using a recirculation system had a significant effect on the absolute growth rate and the coefficient of variation in weight. The best treatment in this study was 5 fish/m2, with a survival rate of 100%, an absolute growth rate of 0.04 g/head/day, a feed conversion ratio of 1.63, and a coefficient of variation of weight of 17.99%.Key words: production performance; seurukan fish; recirculation system; stocking density
Enhancing the Efficacy and Safety of Methotrexate Treatment: A Focus on Drug Interactions (Review)
Authors: Doktorova S. A. , Grabovetskaya Yu. Yu. , Stefanov M. , Rafalskiy V. V. 
Published: April 2024

INTRODUCTION. Methotrexate (MTX) is the main disease-modifying antirheumatic drug (DMARD) and the gold standard for the safety and efficacy evaluation of biologicals and targeted small molecules. However, its narrow therapeutic range, interpatient variability in pharmacokinetics and pharmacodynamics, and potential clinically relevant drug–drug interactions (DDIs) may lead to treatment failure and increase the risk of adverse drug reactions (ADRs).AIM. The study aimed to describe the main clinically significant DDIs associated with MTX used in rheumatic disease therapy and determine possible approaches to addressing this issue based on a literature review.DISCUSSION. MTX is characterised by pharmacokinetic DDIs during absorption, cell penetration, and elimination. Some non-steroidal anti-inflammatory drugs (NSAIDs), theophylline, sulfasalazine, antibacterial agents, and proton pump inhibitors (PPIs) affect MTX elimination and therapeutic effects. The main ADRs associated with MTX include haematotoxicity, hepatotoxicity, lung tissue damage (interstitial pneumonitis and pulmonary fibrosis), and renal dysfunction. The severity of these ADRs depends on the dose, comorbidities, and concomitant therapy. The toxicity of MTX may be increased by the concomitant administration of medicinal products that exhibit haematotoxicity and affect renal function (impair the elimination of medicines). When co-administering MTX and medicines having clinically significant DDIs described in the literature, healthcare providers should consider the risk factors for each individual patient. The most significant risk factors include moderate to severe renal and hepatic impairment, older age, polypharmacy, and hypoalbuminemia.CONCLUSIONS. This article describes potential clinically significant interactions between MTX and certain NSAIDs, antibacterial agents, and PPIs that depend on individual patient characteristics and may increase the toxicity or decrease the effectiveness of MTX. MTX deprescribing, short-term withdrawal, and dosing optimisation may be considered as approaches to DDI risk mitigation.