bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of Subjective Health Among Spouses and Its Relations With Happiness: A Multilevel Analysis in a Nationwide Survey in Turkey
Authors: Tosyali Furkan , Coban-Tosyali Ezgi , Harma Mehmet 
Published: June 2024

AbstractThe current study aims to examine predictors of subjective health, including its relation with happiness, at the individual and family levels. For this purpose, we analyzed data collected from spouses representing each family (9,634 families, N = 19,268). A multilevel analysis was conducted to examine both individual- and family-level variables associated with subjective health evaluations. Individual-level variables were gender, age, education, employment, presence of chronic illness, smoking, alcohol use, and individual happiness. Family-level variables were socioeconomic status, number of children, household size, length of the marriage (in a year), presence of an elderly person who needs care in the household, presence of a disabled person who needs care in the household, and family happiness. The results showed that subjective health is enhanced by being man, younger, employed, highly educated, free from chronic illness, and experiencing greater levels of happiness at the individual level. In addition, poorer subjective health is associated with caring for an elderly or disabled family member and having a higher number of children in the household at the family level. However, individuals had better subjective health at the family level when socioeconomic status was higher, greater family happiness, and greater household size existed. The current study is important since research that simultaneously considers individual- and family-level happiness has been scarce in the literature. Thus, the findings would enhance the current understanding of the link between happiness and health.
Angiopoietin-like protein 2 inhibits thrombus formation
Authors: Zhang Tiantian , Zhang Mingliang , Guo Lingyu , Liu Dongsheng , Zhang Kandi , Bi Changlong , Zhang Peng , Wang Jin , Fan Yuqi , He Qing , Chang Alex C. Y. , Zhang Junfeng 
Published: June 2024

Abstract
Acute myocardial infarction is mainly caused by a lack of blood flood in the coronary artery. Angiopoietin-like protein 2 (ANGPTL2) induces platelet activation and thrombus formation in vitro through binding with immunoglobulin-like receptor B, an immunoglobulin superfamily receptor. However, the mechanism by which it regulates platelet function in vivo remains unclear. In this study, we investigated the role of ANGPTL2 during thrombosis in relationship with ST-segment elevation myocardial infarction (STEMI) with spontaneous recanalization (SR). In a cohort of 276 male and female patients, we measured plasma ANGPTL2 protein levels. Using male Angptl2-knockout and wild-type mice, we examined the inhibitory effect of Angptl2 on thrombosis and platelet activation both in vivo and ex vivo. We found that plasma and platelet ANGPTL2 levels were elevated in patients with STEMI with SR compared to those in non-SR (NSR) patients, and was an independent predictor of SR. Angptl2 deficiency accelerated mesenteric artery thrombosis induced by FeCl3 in Angptl2
–/– compared to WT animals, promoted platelet granule secretion and aggregation induced by thrombin and collogen while purified ANGPTL2 protein supplementation reversed collagen-induced platelet aggregation. Angptl2 deficiency also increased platelet spreading on immobilized fibrinogen and clot contraction. In collagen-stimulated Angptl2

–/–
platelets, Src homology region 2 domain–containing phosphatase (Shp)1-Y564 and Shp2-Y580 phosphorylation were attenuated while Src, Syk, and Phospholipase Cγ2 (PLCγ2) phosphorylation increased. Our results demonstrate that ANGPTL2 negatively regulated thrombus formation by activating ITIM which can suppress ITAM signaling pathway. This new knowledge provides a new perspective for designing future antiplatelet aggregation therapies.
A unified framework to catalogue and classify digital games based on interaction design and validation through clustering techniques
Authors: Cormio L. , Agostinelli T. , Mengoni M. 
Published: June 2024

AbstractThe digital games industry has grown exponentially due to the diversification of games and the increasing multiplicity of the user target base. The market explosion and the great variety make digital game cataloguing and classification challenging issues whose effectiveness can advance scientific research and address design, development and distribution. Firstly, the present study reviews previous cataloguing for video and serious games through systematic literature review and, joining together the findings from the literature review, develops a unified cataloguing model based on five definitions. This model can aid designers in tailoring their applications and contribute to disseminating game design knowledge in academic research. Then, a matrix that correlates design principles and the cataloguing model’s metadata is applied to the cataloguing model, obtaining a unified classification system. Together, they offer a comprehensive framework for understanding the multifaceted landscape of digital games, addressing the limitations of existing domain-specific approaches and providing a versatile tool for game designers. Research validation exploits a two-stage cluster analysis using agglomerative hierarchical and k-means clustering on the data extracted from a sample of digital games. The results show the framework's effectiveness in categorizing digital games without a clear-cut distinction between video and serious games. The system's application in real-world scenarios suggests its potential to guide game development. Future work will refine the proposal based on feedback from digital game designers, expanding the research scope to include a broader range of games.
Approaches to policy framing: deepening a conversation across perspectives
Authors: Dodge Jennifer , Metze Tamara 
Published: June 2024

AbstractSince Rein and Schön developed their approach to policy framing analysis in the1990s, a range of approaches to policy framing have emerged to inform our understanding of policy processes. Prior attempts to illuminate the diversity of approaches to framing in public policy have largely “stayed in their lane,” making distinctions in approaches within shared epistemic communities. The aim in this paper is to map different approaches to framing used in policy sciences journals, to articulate what each contributes to the understanding of the policy process, and to provide a heuristic to aid in deciding how to use the diverse approaches in framing analysis and to further the dialogue across different approaches. To develop the heuristic, we manually coded and analyzed 68 articles published between 1997 and 2018 using “frame” or “framing” in their title or abstract from four policy journals: Critical Policy Studies, Journal of European Public Policy, Policy Sciences, and Policy Studies Journal. We identified five approaches, which we label: sensemaking, discourse, contestation, explanatory and institutional. We have found that these approaches do not align with a simple binary between interpretive and positivist but show variation, particularly along the lines of aims, methodology and methods. In the discussion, we suggest that these five approaches raise four key questions that animate framing studies in policy analysis: (1) Do frames influence policies or are policies manifestations of framing? (2) What is the role of frame contestation in policy conflict? (3) How can the study of frames or framing reveal unheard voices? And (4) how do certain frames/framings become dominant? By introducing these questions, we offer a fresh way scholars might discuss frames and framing in the policy sciences across approaches, to highlight the distinct yet complementary ways they illuminate policy processes.
What does nihilism tell us about modal logic?
Authors: Masterman Christopher James 
Published: June 2024

AbstractBrauer (Philos Stud 179:2751–2763, https://doi.org/10.1007/s11098-022-01793-7, 2022) has recently argued that if it is possible that there is nothing, then the correct modal logic for metaphysical modality cannot include . Here, I argue that Brauer’s argument is unsuccessful; or at the very least significantly weaker than presented. First, I outline a simple argument for why it is not possible that there is nothing. I note that this argument has a well-known solution involving the distinction between truth in and truth at a possible world. However, I then argue that once the semantics presupposed by Brauer’s argument is reformulated in terms of truth at a world, we have good reasons to think that a crucial semantic premise in Brauer’s argument should be rejected in favour of an alternative. Brauer’s argument is, however, no longer valid with this alternative premise. Thus, plausibly Brauer’s argument against is only valid, if it is not sound.
Relationship between reasons for intermittent missing patient-reported outcomes data and missing data mechanisms
Authors: Nielsen Lene Kongsgaard , Mercieca-Bebber Rebecca , Möller Sören , Redder Louise , Jarden Mary , Andersen Christen Lykkegaard , Frederiksen Henrik , Svirskaite Asta , Silkjær Trine , Steffensen Morten Saaby , Pedersen Per Trøllund , Hinge Maja , Frederiksen Mikael , Jensen Bo Amdi , Helleberg Carsten , Mylin Anne Kærsgaard , Abildgaard Niels , King Madeleine T. 
Published: June 2024

Abstract
Purpose
Non-response (NR) to patient-reported outcome (PRO) questionnaires may cause bias if not handled appropriately. Collecting reasons for NR is recommended, but how reasons for NR are related to missing data mechanisms remains unexplored. We aimed to explore this relationship for intermittent NRs.

Methods
Patients with multiple myeloma completed validated PRO questionnaires at enrolment and 12 follow-up time-points. NR was defined as non-completion of a follow-up assessment within seven days, which triggered contact with the patient, recording the reason for missingness and an invitation to complete the questionnaire (denoted “salvage response”). Mean differences between salvage and previous on-time scores were estimated for groups defined by reasons for NR using linear regression with clustered standard errors. Statistically significant mean differences larger than minimal important difference thresholds were interpreted as “missing not at random” (MNAR) mechanism (i.e. assumed to be related to declining health), and the remainder interpreted as aligned with “missing completely at random” (MCAR) mechanism (i.e. assumed unrelated to changes in health).

Results
Most (7228/7534 (96%)) follow-up questionnaires were completed; 11% (802/7534) were salvage responses. Mean salvage scores were compared to previous on-time scores by reason: those due to hospital admission, mental or physical reasons were worse in 10/22 PRO domains; those due to technical difficulties/procedural errors were no different in 21/22 PRO domains; and those due to overlooked/forgotten or other/unspecified reasons were no different in any domains.

Conclusion
Intermittent NRs due to hospital admission, mental or physical reasons were aligned with MNAR mechanism for nearly half of PRO domains, while intermittent NRs due to technical difficulties/procedural errors or other/unspecified reasons generally were aligned with MCAR mechanism.
Phytochemical characterization of callus cultures from the endangered plant Crocus scepusiensis (Rehm. & Woł.) Borbás ex Kulcz.
Authors: Khlifa Heba D. , Sweelam Heba-tollah M. , El-Desoky Ahmed H. , Raslan Mona A. 
Published: June 2024

AbstractCrocus scepusiensis (Rehm. & Woł.) Borbás ex Kulcz., a critically endangered herbaceous plant which serves as a valuable source of bioactive compounds found across Europe and Asia. The aim of this study was to produce a calli from two different plant parts (leaf and shoot tip) for the critically endangered C. scepusiensis through tissue culture techniques, characterize the resulting calli through chemical profiling, with a focus on identifying key phytoconstituents, and lay the groundwork for future research on the biological activities of these calli extracts. Leaf disc and micro shoot tip explants were cultured on Murashige and Skoog (MS) medium supplemented with various concentrations of 6-benzylaminopurine (BA) and α-naphthaleneacetic acid (NAA) to induce organogenic calli. The resulting calli exhibited distinct biochemical profiles. Moreover, a phytochemical analysis was conducted to compare the metabolite composition of callus 1 (derived from leaf discs) and callus 2 (derived from shoot tips). Callus 1 displayed a higher total phenolic content (30.3558 ± 1.3564 mg (GAE)/g) compared to callus 2 (29.1543 ± 0.9754 mg (GAE)/g). Similarly, callus 1 exhibited a greater total flavonoid content (26.0089 ± 1.8029 mg (RE)/g) than callus 2 (18.4464 ± 1.4797 mg (RE)/g). Liquid chromatography-photodiode array-electrospray ionization-tandem mass spectrometry (LC-PDA-ESI-MS/MS) analysis revealed the presence of 26 and 25 constituents in callus 1 and 2, respectively. Fourteen and thirteen of these identified compounds have been previously reported in other Crocus species, with 22 constituents common to both calli. Twelve constituents were reported here in Crocus for the first time as far as we know.
Microplastic Pollution and Risk Assessment in Packaged Teas in Türkiye
Authors: Güzel İzmirli Şule , Gökkaya Ahmet 
Published: June 2024

Abstract
This article presents the first-ever findings on the release of MPs (microplastics) from tea bags containing tea leaves into tea infusions in Türkiye. The study aimed to investigate the possible distribution and abundance of MPs in cup of tea bags and teapot tea bags of fifteen packaged tea brands in Türkiye using ATF/FTIR analysis. The results showed that MPs were found in all the analyzed tea brands. Surprisingly, the highest particle number was observed in the dry tea samples (removed from tea bags) belonging to all brands. Brands A and O had the highest abundance of MPs. All MP particles identified were fiber in shape, and four colors were identified, with a predominance of navy blue. Polyethylene terephthalate (PET) was the most abundant polymer type. The size of MPs varied from 33.65 μm to 1680.20 μm. The daily MP exposure by tea intake was analyzed for male and female groups, and the dietary exposure for males was greater than that for females. According to the MP contamination factor values, a wide variety of MP contamination levels were determined, with a predominance of significant and very high levels of contamination. The mean polymer risk index was determined to be 10.80, indicating a low level of risk. Additionally, this study also provides information on the potential health effects of these harmful MPs. Considering that consuming tea is a significant way for individuals to come into contact with MPs, tea prepared with tea leaves packaged in tea bags could potentially have adverse effects on the health of consumers.

Graphical Abstract
Lipidomic signatures in patients with early-onset and late-onset Preeclampsia
Authors: Huang Yu , Sun Qiaoqiao , Zhou Beibei , Peng Yiqun , Li Jingyun , Li Chunyan , Xia Qing , Meng Li , Shan Chunjian , Long Wei 
Published: June 2024

Abstract
Background
Preeclampsia is a pregnancy-specific clinical syndrome and can be subdivided into early-onset preeclampsia (EOPE) and late-onset preeclampsia (LOPE) according to the gestational age of delivery. Patients with preeclampsia have aberrant lipid metabolism. This study aims to compare serum lipid profiles of normal pregnant women with EOPE or LOPE and screening potential biomarkers to diagnose EOPE or LOPE.

Methods
Twenty normal pregnant controls (NC), 19 EOPE, and 19 LOPE were recruited in this study. Untargeted lipidomics based on ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was used to compare their serum lipid profiles.

Results
The lipid metabolism profiles significantly differ among the NC, EOPE, and LOPE. Compared to the NC, there were 256 and 275 distinct lipids in the EOPE and LOPE, respectively. Furthermore, there were 42 different lipids between the LOPE and EOPE, of which eight were significantly associated with fetal birth weight and maternal urine protein. The five lipids that both differed in the EOPE and LOPE were DGTS (16:3/16:3), LPC (20:3), LPC (22:6), LPE (22:6), PC (18:5e/4:0), and a combination of them were a potential biomarker for predicting EOPE or LOPE. The receiver operating characteristic analysis revealed that the diagnostic power of the combination for distinguishing the EOPE from the NC and for distinguishing the LOPE from the NC can reach 1.000 and 0.992, respectively. The association between the lipid modules and clinical characteristics of EOPE and LOPE was investigated by the weighted gene co-expression network analysis (WGCNA). The results demonstrated that the main different metabolism pathway between the EOPE and LOPE was enriched in glycerophospholipid metabolism.

Conclusions
Lipid metabolism disorders may be a potential mechanism of the pathogenesis of preeclampsia. Lipid metabolites have the potential to serve as biomarkers in patients with EOPE or LOPE. Furthermore, lipid metabolites correlate with clinical severity indicators for patients with EOPE and LOPE, including fetal birth weight and maternal urine protein levels.
Epigenetic age acceleration is a distinctive trait of epithelioid sarcoma with potential therapeutic implications
Authors: Haefliger Simon , Chervova Olga , Davies Christopher , Loh Chet , Tirabosco Roberto , Amary Fernanda , Pillay Nischalan , Horvath Steve , Beck Stephan , Flanagan Adrienne M. , Lyskjær Iben 
Published: June 2024

AbstractRecently, DNA methylation clocks have been proven to be precise age predictors, and the application of these clocks in cancer tissue has revealed a global age acceleration in a majority of cancer subtypes when compared to normal tissue from the same individual. The polycomb repressor complex 2 plays a pivotal role in the aging process, and its targets have been shown to be enriched in CpG sites that gain methylation with age. This complex is further regulated by the chromatin remodeling complex SWItch/Sucrose Non-Fermentable and its core subunit, notably the tumor suppressor gene SMARCB1, which under physiological conditions inhibits the activity of the polycomb repressor complex 2. Hence, the loss of function of core members of the SWItch/sucrose non-fermentable complex, such as the tumor suppressor gene SMARCB1, results in increased activity of polycomb repressor complex 2 and interferes with the aging process. SMARCB1-deficient neoplasms represent a family of rare tumors, including amongst others malignant rhabdoid tumors, atypical teratoid and rhabdoid tumors, and epithelioid sarcomas. As aging pathways have recently been proposed as therapeutic targets for various cancer types, these tumors represent candidates for testing such treatments. Here, by deriving epigenetic age scores from more than 1000 tumor samples, we identified epigenetic age acceleration as a hallmark feature of epithelioid sarcoma. This observation highlights the potential of targeting aging pathways as an innovative treatment approach for patients with epithelioid sarcoma.
Pediatric metabolic (dysfunction)-associated fatty liver disease: current insights and future perspectives
Authors: Vimalesvaran Sunitha , Vajro Pietro , Dhawan Anil 
Published: June 2024

AbstractThe historical use of the term non-alcoholic fatty liver disease (NAFLD) in obese/overweight children has been controversial as to the appropriateness of this terminology in children, and lately, in adults too. Newer game-changer terminology, metabolic (dysfunction)-associated fatty liver disease (MAFLD), for this condition signifies a positive step forward that addresses the limitations of the previous definition for both adults and children. The prevalence of MAFLD has surged in tandem with the global rise in obesity rates, establishing itself as a predominant cause of chronic liver disease in both adult and pediatric populations. The adoption of the recently proposed nomenclature reflects a more encompassing comprehension of the disease and its etiology compared to its predecessor, NAFLD. Notably, the revised terminology facilitates the recognition of MAFLD as an autonomous condition while acknowledging the potential coexistence of other systemic fatty liver disorders. Particularly in children, this includes various paediatric-onset genetic and inherited metabolic disorders, necessitating thorough exclusion, especially in cases where weight loss interventions yield no improvement or in the absence of obesity. MAFLD presents as a multifaceted disorder; evidence suggests its origins lie in a complex interplay of nutritional, genetic, hormonal, and environmental factors. Despite advancements, current non-invasive diagnostic biomarkers exhibit limitations in accuracy, often necessitating imaging and histological evaluations for definitive diagnosis. While dietary and lifestyle modifications stand as cornerstone measures for MAFLD prevention and management, ongoing evaluation of therapeutic agents continues. This article provides an overview of the latest developments and emerging therapies in the realm of paediatric MAFLD.
Investigating the Effects of CoMoCrSi Powder Composition and Particle Size, and Annealing Heat Treatment on Microstructure and Mechanical and Tribological Performance of HVOF Sprayed Coatings
Authors: Ertürk Murat Tolga , Tirkeş Süha , Gür Cemil Hakan 
Published: June 2024

AbstractAn investigation was conducted to analyze the mechanical properties, wear behavior, and microstructure of coatings formed by high-velocity oxygen fuel spraying of CoMoCrSi powders. The effects of varying Cr concentration and particle sizes before and after heat treatment at 900 °C for 4 h were studied comparatively. The increase in Cr and Mo elements in the expanse of Co increased the structure's hardness before and after the heat treatment. As this increase was 10% in as-sprayed conditions, annealing raised the increase to 30%. Splat boundaries were the most vulnerable constituents against forces, creating a significant disadvantage in terms of structural integrity and affecting the overall performance. After annealing, the boundary strengths experienced a remarkable four-fold increase and cracks and fractures reduced significantly. The susceptibility of splat boundaries had a detrimental effect on room temperature wear behavior, and increased boundary densities led to a marked reduction in wear performance. Heat treatment induced improvements significantly increased the room temperature wear performance. At elevated temperature, the formation of oxide layers composed of CoMoO4, Co3O4, MoO3, and Cr2O3 overcame the weaknesses of the as-sprayed coating, reducing both the friction coefficient and wear losses. A reduced Co ratio led to the formation of an oxide blend with a higher concentration of Mo and Cr oxides on the surface, further improving the coating's wear behavior.
Graphical Abstract
There is No Supporting Evidence for a Far Transfer of General Perceptual or Cognitive Training to Sports Performance
Authors: Fransen Job 
Published: June 2024

AbstractIn this opinion piece I reiterate the concepts of near and far transfer as previously described in the psychological literature. I show that despite very limited evidence, many technologies, tools and methods make questionable claims of eliciting far transfer from generic perceptual and/or cognitive training to sports performance. Specifically, this commentary illustrates with studies on stroboscopic vision, neurofeedback training and executive functions that the claims made for the beneficial effects of these training methods are currently unsubstantiated. I conclude that greater scrutiny by researchers is needed in order to assist practitioners to make better-informed decisions about tools, methods and technologies that may aid sports performance.