bluuebunny/crossref_metadata_2025_split huggingface dataset:
TheEKFCequation outperforms theCKD‐EPIandCKiDequations forGFRestimation in adolescent and young adult kidney transplant patients
Authors: Grosyeux Chloé , Alla Asma , Barbé Françoise , Dubourg Laurence Derain , Chardon Laurence , Guéant Jean‐Louis , Frimat Luc , Oussalah Abderrahim , Vrillon Isabelle 
Published: May 2024

AbstractAimThis study evaluated the bias and accuracy of the CKD‐EPI/CKiD and EKFC equations compared with the reference exogenous tracer‐based assessment of glomerular filtration rate (GFR) in adult and pediatric patients according to their renal transplant status.MethodsWe assessed the bias andP30accuracy of the CKD‐EPI/CKiD and EKFC equations compared with iohexol‐based GFR measurement.ResultsIn the overall population (n = 59), the median age was 29 years (IQR, 16.0–46.0) and the median measured GFR was 73.9 mL/min/1.73m2(IQR, 57.3–84.6). Among non‐kidney transplant patients, the median was 77.7 mL/min/1.73m2(IQR, 59.3–86.5), while among kidney transplant patients, it was 60.5 mL/min/1.73m2(IQR, 54.2–66.8). The bias associated with the EKFC and CKD‐EPI/CKiD equations was significantly higher among kidney transplant patients than among non‐kidney transplant patients, with a difference between medians (Hodges–Lehmann) of +10.4 mL/min/1.73m2(95% CI, 2.2–18.9;p = .02) for the EKFC and +12.1 mL/min/1.73m2(95% CI, 4.2–21.4;p = .006) for the CKD‐EPI/CKiD equations. In multivariable analysis, kidney transplant status emerged as an independent factor associated with a bias of >3.4 mL/min/1.73m2(odds ratio, 7.7; 95% CI, 1.4–43.3;p = .02) for the EKFC equation and a bias of >13.4 mL/min/1.73m2(odds ratio, 15.0; 95% CI, 2.6–85.7;p = .002) for the CKD‐EPI/CKiD equations.ConclusionIn our study, which included adolescent and young adult kidney transplant patients, both the CKD‐EPI/CKiD and EKFC equations tended to overestimate the measured glomerular filtration rate, with the EKFC equation exhibiting less bias. Renal transplant status significantly influenced the degree of estimation bias.image
Lysine 2‐hydroxyisobutyrylation proteomics analyses reveal the regulatory mechanism of CaMYB61‐CaAFR1 module in regulating stem development in Capsicum annuum L.
Authors: Li Qing , Fu Canfang , Hu Bowen , Yang Bozhi , Yu Huiyang , He Huan , Xu Qing , Chen Xuejun , Dai Xiongze , Fang Rong , Xiong Xingyao , Zhou Kunhua , Yang Sha , Zou Xuexiao , Liu Zhoubin , Ou Lijun 
Published: May 2024

SUMMARYPlant stems constitute the most abundant renewable resource on earth. The function of lysine (K)‐2‐hydroxyisobutyrylation (Khib), a novel post‐translational modification (PTM), has not yet been elucidated in plant stem development. Here, by assessing typical pepper genotypes with straight stem (SS) and prostrate stem (PS), we report the first large‐scale proteomics analysis for protein Khib to date. Khib‐modifications influenced central metabolic processes involved in stem development, such as glycolysis/gluconeogenesis and protein translation. The high Khib level regulated gene expression and protein accumulation associated with cell wall formation in the pepper stem. Specially, we found that CaMYB61 knockdown lines that exhibited prostrate stem phenotypes had high Khib levels. Most histone deacetylases (HDACs, e.g., switch‐independent 3 associated polypeptide function related 1, AFR1) potentially function as the “erasing enzymes” involved in reversing Khib level. CaMYB61 positively regulated CaAFR1 expression to erase Khib and promote cellulose and hemicellulose accumulation in the stem. Therefore, we propose a bidirectional regulation hypothesis of “Khib modifications” and “Khib erasing” in stem development, and reveal a novel epigenetic regulatory network in which the CaMYB61‐CaAFR1 molecular module participating in the regulation of Khib levels and biosynthesis of cellulose and hemicellulose for the first time.
Dermoid cysts formation is a complication of wound pinch grafting in a horse: A case report
Authors: Pressanto Maria Chiara , Bombonato Cecilia , Foote Alastair K. , Coomer Richard P. C. 
Published: May 2024

AbstractObjectivesTo describe dermoid cyst formation as an uncommon complication of the pinch grafting technique in horses.Study designCase report.AnimalA 8 year old Arabian gelding.MethodsClinical presentation, imaging, treatment, and histopathology records were reviewed. The horse originally presented due to delayed healing of a laceration to the distal aspect of the metatarsus. The wound was treated initially with debridement and it was allowed to fill with healthy granulation tissue prior to pinch grafting. Two months after grafting, the horse started to show self‐mutilation behavior targeting the wound site. Ultrasonographic examination revealed the presence of cystic lesions in the subcutaneous tissue in the wound bed and adjacent to the long digital extensor tendon.ResultsTreatment involved surgical excision of the cysts, which resulted in a resolution of the self‐mutilation episodes. The specimens were submitted for histopathological investigation, which revealed findings compatible with dermoid cyst formation, suspected to be secondary to the skin‐grafting procedure.ConclusionDermoid cysts formation should be considered as a potential differential diagnosis for skin graft complications in horses.
Topological endomorphism rings of tilting complexes
Authors: Hrbek Michal 
Published: May 2024

AbstractIn a compactly generated triangulated category, we introduce a class of tilting objects satisfying a certain purity condition. We call these the decent tilting objects and show that the tilting heart induced by any such object is equivalent to a category of contramodules over the endomorphism ring of the tilting object endowed with a natural linear topology. This extends the recent result for n‐tilting modules by Positselski and Št'ovíček. In the setting of the derived category of modules over a ring, we show that the decent tilting complexes are precisely the silting complexes such that their character dual is cotilting. The hearts of cotilting complexes of cofinite type turn out to be equivalent to the category of discrete modules with respect to the same topological ring. Finally, we provide a kind of Morita theory in this setting: Decent tilting complexes correspond to pairs consisting of a tilting and a cotilting‐derived equivalence as described above tied together by a tensor compatibility condition.
Velocity and Energy Consumption Prediction of Medium-Duty Electric Trucks Considering Road Features and Traffic Conditions
Authors: Ahn Hyunjin , Shen Heran , Zhou Xingyu , Kung Yung-Chi , Maweu John , Wang Junmin 
Published: May 2024

Abstract
Electric vehicles (EVs) have emerged as a promising solution to address environmental concerns, especially benefiting urban delivery and last-mile fleets due to their unique operational characteristics. Despite the potential advantages, the adoption of electric trucks (eTrucks) into delivery fleets has been slow, mainly due to the challenge posed by eTrucks' limited driving range. Consequently, a reliable method for predicting the eTrucks' energy consumption in fleet route planning is essential, and the accuracy of the velocity trajectory forecast forming the fundamental basis. This paper introduces a data-driven approach to predict the velocity and energy consumption of medium-duty (MD) eTrucks, considering various road features, payload, and traffic conditions. A gated recurrent unit (GRU) is trained using traffic-labeled characteristic features specific to each road segment within a delivery route. For every predefined route, the GRU generates the velocity profile by analyzing a sequence of traffic states predicted from the maximum entropy Markov model (MEMM). Corresponding eTruck energy consumption is estimated using an autonomie truck model. Real-world EV data are used to evaluate the proposed method, and the results demonstrate that the model effectively utilizes the information, achieving high accuracy in predicting both eTruck velocity and energy consumption.
Paper-based versus digital-based learning among undergraduate medical, nursing and pharmaceutical students in Japan: a cross-sectional study
Authors: Yamada Masaaki , Sekine Michikazu , Tatsuse Takashi 
Published: May 2024

ObjectiveSince the emergence of COVID-19, university education has drastically transformed into digital-based learning (DBL). Online education has been well recognised as a promising mode of teaching; however, only a limited number of studies have reported the students’ preferred format for academic learning.DesignCross-sectional.SettingThe study was conducted in a university setting in Japan. A Google Forms online questionnaire was distributed to the participants between April and May 2022.ParticipantsA total of 939 undergraduate medical, nursing and pharmaceutical students in the pre-clinical grade were recruited, and 344 were included in the final analysis.Primary and secondary outcomeThe questionnaire assessed students’ format preferences between paper-based learning (PBL) and DBL as it pertained to academic performance and eyestrain. In terms of academic performance, comprehension, memory retention and absorption (concentration) were assessed. We also explored the association between students’ daily time spent using DBL and their digital preference by the Cochran-Armitage trend test and logistic regression analysis.ResultsA total of 344 (191 medical, 73 nursing and 80 pharmaceutical) university students completed the questionnaire (response rate 36.6%). An even distribution was observed in the preferred learning format for comprehension: PBL (32.0%), both formats equivalent (32.8%) and DBL (35.2%; digital preference). Only few students preferred DBL for memory retention (6.1%), absorption (6.7%) and eyestrain (1.2%). Although a positive association was observed between daily time spent using DBL and digital preference for comprehension, there was no association for memory retention, absorption and eyestrain.ConclusionAmong university students, DBL was just as preferred as PBL for comprehension; however, only a few students reported that DBL was better in terms of memory retention, absorption and eyestrain. A learning environment where students can study using PBL should be continued.
Internet-delivered cognitive–behaviour therapy for anxiety related to asthma: study protocol for a randomised controlled trial
Authors: Bonnert Marianne , Nash Stephen , Andersson Erik M , Bergström Sten Erik , Janson Christer , Almqvist Catarina 
Published: May 2024

IntroductionThere is an established association between asthma and anxiety. The overlap between asthma symptoms and symptoms of anxiety may cause individuals to overestimate their asthma severity and restrict their daily activities leading to a low quality of life. There is currently weak evidence for treatments targeting anxiety related to asthma, but cognitive–behavioural therapy (CBT) has shown some promising but mixed results. The current randomised controlled trial will investigate if exposure-based internet-delivered CBT (Internet-CBT) is more effective than treatment as usual+medical education (TAU+ME) to relieve symptoms of anxiety and asthma control.Methods and analysis90 participants will be randomised 1:1 to 8 weeks of Internet-CBT or TAU+ME. The primary outcome, the patient-reported Catastrophising Asthma Scale, will be analysed from baseline to the primary endpoint at 16 weeks using hierarchical linear mixed model of the slope over time. Secondary outcomes, such as asthma control, quality of life and forced expiratory volume in 1 s, will be analysed correspondingly.Ethics and disseminationAll participants will be informed about the study and leave their consent before study entry. All results will be analysed at group level and reported through publication in a peer-reviewed scientific journal within the field. The study received ethical approval by the Swedish Ethical Review Authority in January 2020 (ID: 2019-05985; 2022-01117-02).Trial registration numberRegistered at ClinicalTrials.gov (ID:NCT04230369).
Case 329
Authors: Shetty Anup S. , Tsai Richard 
Published: May 2024

History A 45-year-old female patient who was previously healthy presented after several weeks of fullness in the right upper quadrant of the abdomen. The patient did not experience pain, nausea, vomiting, or jaundice, and had no contributory past medical or surgical history, including no history of malignancy. Upon examination, vital signs were within normal limits and the patient was appeared well with soft palpable fullness in the right upper quadrant. The abdomen was nontender and nondistended. Laboratory investigation revealed no abnormalities, with a normal complete blood cell count and normal serum tumor markers that included α-fetoprotein (<2.0 ng/mL; reference, <8.3 ng/mL), cancer antigen 19–9 (21.6 U/mL; reference, <35 U/mL), and carcinoembryonic antigen (1.3 ng/mL; reference, <5 ng/mL). CT of the abdomen and pelvis was performed with intravenous contrast material in the emergency department ( Fig 1 ). Subsequently, combined MRI and MR cholangiopancreatography of the abdomen was performed with and without intravenous contrast material for further evaluation ( Fig 2 ). CT of the chest performed during the same encounter was unremarkable.
Safety, Tolerability, and Pharmacodynamics of AZD3366 (Optimized Human CD39L3 Apyrase) Alone and in Combination With Ticagrelor and Acetylsalicylic Acid: A Phase 1, Randomized, Placebo‐Controlled Study
Authors: Kardassis Dimitris , Egnell Ann‐Charlotte , Åstrand Magnus , Daniels Samuel J. , Whatling Carl , Fjellström Ola , Gabrielsen Anders 
Published: May 2024

Background

ADP and ATP are importantly involved in vascular and thrombotic homeostasis, via multiple receptor pathways. Blockade of ADP P2Y
12
receptors inhibits platelet aggregation and represents an effective cardiovascular disease prevention strategy. AZD3366 (APT102), a long‐acting recombinant form of an optimized CD39L3 human apyrase, has effectively reduced ATP, ADP, and platelet aggregation and provided tissue protection in preclinical models, features that could be very beneficial in treating patients with cardiovascular disease.

Methods and Results
We conducted this phase 1, first‐in‐human study of single ascending doses of intravenous AZD3366 or placebo, including doses added to dual antiplatelet therapy with ticagrelor and acetylsalicylic acid. The primary objective was safety and tolerability; secondary and exploratory objectives included pharmacokinetics, pharmacodynamics (measured as inhibition of platelet aggregation), adenosine diphosphatase (ADPase) activity, and ATP/ADP metabolism. In total, 104 participants were randomized. AZD3366 was generally well tolerated, with no major safety concerns observed. ADPase activity increased in a dose‐dependent manner with a strong correlation to AZD3366 exposure. Inhibition of ADP‐stimulated platelet aggregation was immediate, substantial, and durable. In addition, there was a prompt decrease in systemic ATP concentration and an increase in adenosine monophosphate concentrations, whereas ADP concentration appeared generally unaltered. At higher doses, there was a prolongation of capillary bleeding time without detectable changes in the ex vivo thromboelastometric parameters.

Conclusions
AZD3366 was well tolerated in healthy participants and demonstrated substantial and durable inhibition of platelet aggregation after single dosing. Higher doses prolonged capillary bleeding time without detectable changes in ex vivo thromboelastometric parameters.

Registration

URL:
https://www.clinicaltrials.gov
; Unique Identifier: NCT04588727.
Examining the Relationship Between E-Cigarette Status and Wearable Device Use on Physical Activity Levels in U.S. Adults
Authors: Tiralla Gillian , Tamulevicius Nauris , Martinasek Mary P. , Leung Willie 
Published: May 2024

Purpose The aim of this analysis is to investigate physical activity levels amongst e-cigarette users based on their wearable device use. Design Cross-sectional secondary data analysis using 2017 Behavioral Risk Factor Surveillance Survey (BRFSS). Setting Data from the 2017 BRFSS were used. Sample 5,562 U.S. adults (age 18+). Measures Self-reported physical activity related variables from U.S. adults (age 18+). Analysis Separate unadjusted and adjusted linear regression models were performed for each of the dependent variables using survey analysis. Results Non-users of wearable devices and e-cigarettes account for 96.6% (95%CI [95.7, 97.6]) of the sample, whereas users of wearable devices and e-cigarettes account for 3.3% (95%CI [1.2, 5.4]) of the sample. Those who use e-cigarettes participate in almost 50% less vigorous physical activity minutes per week than nonusers, 46 (95%CI [0.43, 91.57]) and 93 (95%CI [80.59, 106.34]) minutes respectively. Individuals who use e-cigarettes and use wearable devices were found to spend significantly more time in total physical activity per week in both the unadjusted and adjusted linear regressions, P = =0.01 and P = =0.04 respectively. Conclusion The use of e-cigarettes, wearable devices, or both technologies may influence the physical activity levels of its users. Additional research is needed to better understand the association between physical activity levels and the usage of these technologies.
Informativeness of Announcement Returns in Cross-border Acquisition Completion: A Perspective from Emerging Economies
Authors: Ahuja Sugandh , Singh Shveta , Yadav Surendra Singh 
Published: May 2024

This study examines the informative role of announcement returns in the deal-closing decision for cross-border acquisitions from emerging economies. Using a sample of 903 acquisitions from five emerging economies: Brazil, Russia, India, China, and South Africa (BRICS), we find that the likelihood of deal completion increases if the market reacts favorably at the time of announcement. Further, we investigate if the relationship between announcement returns and deal completion becomes more significant under increased information asymmetry. Empirical results attest that the relationship between the market reaction and deal completion becomes more pronounced in unrelated deals and deals without advisors. JEL Codes: G14, G34
Lijing-Anfei Decoction Attenuates COPD in a Mouse Model: Network Pharmacology Analysis, Molecular Docking, and Experimental Validation
Authors: Zhu Jiajia , Liu Jie , Jia Wei , Shao Guoqiang , Xu Haizhu 
Published: May 2024

Background Today, network pharmacology and molecular docking were utilized for investigation and prediction of possible mechanisms in fields such as pharmacognosy and traditional Chinese medicine formulas when treating disease. Purpose Chronic obstructive pulmonary disease (COPD) is caused by exposure to toxic particles and leads to chronic bronchitis and lung dysfunction. Lijing-Anfei decoction (LAD) is a traditional Chinese herbal decoction used to cure COPD. This study explored the effects of this decoction and its intrinsic mechanism in a COPD mouse model. Materials and Methods Possible targets were retrieved from several databases and combined using Veny. Protein-protein interaction (PPI) networks were constructed via STRING database. Gene ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed via the Metascape database. The COPD model was established by exposing the mice to cigarette smoke for 12 weeks. After the model was established, LAD was administered for four weeks. Enzyme-linked immunosorbent assay (ELISA) was performed, and body weights and lung wet/dry ratios were measured. Lung morphology was observed by hematoxylin-eosin staining. Results After the screening, 32 overlapping targets were used to generate PPI networks and the following hub genes were identified: JUN, IL6, RELA, IL1B, HIF1A, MAPK1, PPARG, PTGS2, MAPK14, and NOS2. The KEGG analysis indicated that hypoxia-inducible factor-1 (HIF-1) and other signaling pathways are possible signaling pathways. The molecular docking results demonstrated tight links between major compounds and their targets. In animal experiments, LAD attenuated body weight loss, downregulated inflammatory cell numbers, and inhibited the enhancement of Fe2+ levels. The mean linear intercept index changes indicated that LAD ameliorated the lung structural damage. ELISA revealed that it downregulated pro-inflammatory cytokine levels and inhibited excessive oxidant production, TdT-mediated dUTP-biotin nick end labeling assay demonstrated that it alleviated cell death in the lungs, and immunohistochemical staining revealed that it inhibited HIF-1α and PTGS2. ML228—an agonist of HIF-1—blocked the effect of LAD, validating the role of HIF-1-mediated ferroptosis in the pharmacological effects of this decoction. Conclusion This study revealed that LAD was successful in treating COPD.
Beyond Survival: A Scoping Review on the Sexual Health of Sexual and Gender Minority Women Following Curative Cancer Treatment
Authors: Miles Heather S. , Wickersham Karen E. , Hein L. C. 
Published: May 2024

Introduction: To explore the existing research on sexual health experiences of sexual and gender minority women (SGMW) post-curative cancer treatment. Methodology: This scoping review was guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews. Four articles that focused on sexual health experiences of SGMW post-curative cancer treatment were included. Results: Four themes were identified: (a) sexual function; (b) sexual orientation and gender identity, including disclosure and health care provider reactions; (c) relationship dynamics, such as relationship status and the quality of romantic relationships; and (d) body image. Discussions: The findings underscore substantial challenges faced by SGMW cancer survivors in achieving optimal sexual well-being, impacting their access to post-treatment care. This study advocates for more expansive research efforts involving diverse participant cohorts, extending beyond breast cancer, to gain deeper insights into these critical issues.
A Review of Intense Pulsed Light in the Treatment of Ocular Rosacea
Authors: Shergill Mahek , Khaslavsky Sophie , Avraham Shani , Kashetsky Nadia , Zaslavsky Kirill , Mukovozov Ilya 
Published: May 2024

Introduction: Ocular rosacea is an underdiagnosed form of rosacea that may occur with or without typical cutaneous signs of rosacea. One of the common manifestations is dry eyes. Although the use of intense pulsed light (IPL) in the treatment of rosacea-related dry eyes has been reported, a recent review is lacking. Methods: A scoping review was performed to summarize the efficacy of IPL in the treatment of ocular rosacea. Results: Five articles were included, representing 108 patients, with a mean age of 58.4 years. Based on available data, 59.2% (n = 58/98) were female. The studies detailed the use of IPL in combination with meibomian gland expression treatment. Overall, 91% (n = 89/98) of patients with ocular rosacea treated with IPL had a partial response and 9% (n = 9/98) had no response. IPL therapy did not lead to complete recovery in any of the included patients. One participant experienced an adverse event across the included studies. Conclusions: IPL is a promising treatment modality for ocular rosacea, as demonstrated by its ability to relieve dry eye symptoms with limited adverse events. Further research into this novel treatment is necessary to ascertain its role in the management of ocular rosacea.