bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of magnetic resonance imaging in fetal renal anomalies
Authors: Gupta Prerna , Kumar Sunesh , Sharma Raju , Gadodia Ankur , Roy Kallol K. , Sharma Jai B. 
Published: September 2010

AbstractObjectiveTo evaluate the role of magnetic resonance imaging (MRI) in fetuses with suspected renal anomalies after ultrasonography.MethodsEighty‐six consecutive singleton fetuses with suspected malformation after ultrasound underwent MRI at the All India Institute of Medical Sciences, New Delhi, India, from January 1, 2005, to July 31, 2008. The study group comprised 27 fetuses with suspected renal anomaly on ultrasound. The MRI findings were compared with the sonographic findings, and their impact on management was assessed. Postpartum imaging, autopsy, or surgical findings were taken as the gold standard of assessment and diagnosis.ResultsThe sonographic findings in 19 (70.4%) cases were confirmed by MRI; additional findings were obtained with MRI in 7 (25.9%) cases, 3 (11.1%) of which resulted in a change in postnatal management. Additional information was also provided by MRI for 5 (50.0%) of the 10 fetuses with oligohydramnios. The MRI diagnosis was incorrect—compared with ultrasound and gold standard—for 2 (7.4%) fetuses.ConclusionUltrasound is the imaging modality of choice for the diagnosis of fetal renal anomalies; fetal MRI is a useful adjunct, especially when ultrasound is inconclusive owing to oligohydramnios.
A study of 579 pregnant women with premature rupture of membranes at term
Authors: Li Kui , Wang Yanping , Li Haiyan , Yang Huixia 
Published: September 2010

AbstractObjectiveTo determine the best management for women with premature rupture of membranes at term.MethodIn 2008, 579 women admitted to Peking University First Hospital for premature rupture of membranes (PROM) at term were allocated to one of 3 groups. Group 1 (n = 292) consisted of those whose labor began spontaneously within 12 hours of PROM; group 2 (n = 234), of those whose labor did not begin within 12 hours of PROM and were induced with oxytocin; and group 3 (n = 53), of those who accepted a cesarean delivery immediately after PROM was diagnosed. The χ2 test was used to compare the rates of intrauterine and neonatal infection in these 3 groups.ResultsCompared with the intrauterine and neonatal infection rates for group 1 (3.4% and 13.7%) and group 3 (1.9% and 3.8%), the corresponding rates were higher for group 2 (10.7% and 21.8%) (P < 0.05). In group 2, 76.5% of the women began labor within 24 hours of induction and 92.7% of these within 12 hours.ConclusionIn women at term, induction should be performed immediately after PROM is diagnosed, as it is likely to fail when labor does not begin within 12 hours of oxytocin administration.
ON EXTRINSICALLY SYMMETRIC HYPERSURFACES OF ℍn×ℝ
Authors: CALVARUSO GIOVANNI , KOWALCZYK DANIEL , VAN DER VEKEN JOERI 
Published: September 2010

AbstractTotally umbilical, semi-parallel and parallel hypersurfaces of ℍn×ℝ are completely classified. More examples arise than in the analogous study on the ambient space 𝕊n×ℝ.
‘Sexual chemistry’ before the Pill: science, industry and chemical contraceptives, 1920–1960
Authors: LÖWY ILANA 
Published: September 2010

AbstractThe history of contraceptives met the history of drugs long before the invention of the contraceptive pill. In the first half of the twentieth century, numerous pharmaceutical laboratories, including major ones, manufactured and marketed chemical contraceptives: jellies, suppositories, creams, powders and foams applied locally to prevent conception. Efforts to put an end to the marginal status of these products and to transform them into ‘ethical’ drugs played an important role in the development of standardized laboratory tests of efficacy of contraceptive preparations; debates on the validity of such tests; evaluation of the long-term toxicity of chemical compounds; and the rise of collaborations between activists, non-profit organizations and the pharmaceutical industry. Chemical contraceptives were initially associated with quack medicine, shady commercial practices and doubtful morality. Striving to change the status of contraceptives and to promote safe and efficient products that reduced fertility in humans shaped some of the key features of the present-day production and regulation of pharmaceuticals.
HIGH FERTILITY REGIONS IN BANGLADESH: A MARRIAGE COHORT ANALYSIS
Authors: ISLAM SABINA , ISLAM MOHAMMAD AMIRUL , PADMADAS SABU S. 
Published: September 2010

SummaryBangladesh represents one of the few countries in south Asia where the pace of fertility decline has been unprecedented over the last three decades. Although there has been significant reduction in fertility levels at the national level, regional variations continue to persist, especially in Sylhet and Chittagong where the total fertility rates are well above the country average. Using data from three consecutive Bangladesh Demographic and Health Surveys (BDHSs) this paper assesses how fertility patterns in Sylhet and Chittagong differ from the rest of Bangladesh through a marriage cohort analysis of the parity progression ratios, and examines the factors determining the transition rates to higher parity in these two regions. Three cohorts of women are identified: those married during 1965–1974, 1975–84 and 1985–94. The results show that the probability that a woman from the recent cohort in Sylhet or Chittagong who had a third birth will have a fourth birth is nearly twice that of her counterpart in other regions. Social characteristics such as education, occupation, religion and residence have no effect on fertility in Sylhet and Chittagong. Additional period-specific analyses using the 2007 BDHS data show that women in Sylhet are considerably more likely to have a third or fourth birth sooner than those in other divisions, especially Khulna. The findings call for specific family planning policy interventions in Sylhet and Chittagong ensuring gender equity, promoting female education and delaying entry into marriage and childbearing.
Injection augmentation of arytenoids after partial laryngectomy: case series
Authors: Ghosh A , Guss J , Ruiz C E , Quon H , Weinstein G S , Mirza N 
Published: September 2010

AbstractBackground:We undertook collagen injection laryngoplasty to achieve arytenoid augmentation in patients with dysphagia and persistent aspiration following partial laryngectomy, and we evaluated the efficacy of arytenoid augmentation in aiding neoglottic closure and ensuring airway safety.Methods:Two patients with persistent swallowing impairment after partial laryngectomy were studied. Swallowing was evaluated using fibre-optic endoscopy, and modified barium swallow study. Collagen was then injected into the arytenoid mucosa to achieve neoglottic competence.Results:The patients were followed up for up to two years. Both patients showed a marked improvement in neoglottic competence, as evaluated by fibre-optic and flexible endoscopy at three-month and one-year follow-up appointments.Conclusion:Arytenoid augmentation by injection laryngoplasty can be considered a safe and effective surgical tool for the treatment of dysphagia with persistent aspiration following partial laryngectomy.
Aspergillus pachymeningitis mimicking nasopharyngeal carcinoma
Authors: Chan H S , Yuen H Y , Ng W K , Vlantis A C , Ahuja A T , Tong C F M , van Hasselt C A 
Published: September 2010

AbstractObjectives:We report a case of otogenic fungal pachymeningitis in a diabetic patient who presented with multiple cranial nerve palsies and nasopharyngeal swelling.Methods:We present a case report, we describe the investigations, management and clinical course of fungal pachymeningitis, and we present a review of the world literature on fungal and non-fungal pachymeningitis.Results:To our knowledge, this is the first report of fungal pachymeningitis with magnetic resonance imaging features suggestive of nasopharyngeal carcinoma. It is also the first reported case with aspergillus cultured from both a dural biopsy and the ear canal.Conclusion:Fungal pachymeningitis is a rare condition which may present to otorhinolaryngologists. Its clinical and radiological findings can be confused with those of nasopharyngeal carcinoma; fungal pachymeningitis should thus be included in the differential diagnosis of nasopharyngeal carcinoma.
Applying problem-based learning to otolaryngology teaching
Authors: Abou-Elhamd K A , Rashad U M , Al-Sultan A I 
Published: September 2010

AbstractObjectives:Undergraduate medical education requires ongoing improvement in order to keep pace with the changing demands of twenty-first century medical practice. Problem-based learning is increasingly being adopted in medical schools worldwide. We review its application in the specialty of ENT, and we present our experience of using this approach combined with more traditional methods.Methods:We introduced problem-based learning techniques into the ENT course taught to fifth-year medical students at Al-Ahsa College of Medicine, King Faisal University, Saudi Arabia. As a result, the teaching schedule included both clinical and theoretical activities. Six clinical teaching days were allowed for history-taking, examination techniques and clinical scenario discussion. Case scenarios were discussed in small group teaching sessions. Conventional methods were employed to teach audiology and ENT radiology (one three-hour session each); a three-hour simulation laboratory session and three-hour student presentation were also scheduled. In addition, students attended out-patient clinics for three days, and used multimedia facilities to learn about various otolaryngology diseases (in another three-hour session). This input was supplemented with didactic teaching in the form of 16 instructional lectures per semester (one hour per week).Conclusion:From our teaching experience, we believe that the application of problem-based learning to ENT teaching has resulted in a substantial increase in students' knowledge. Furthermore, students have given encouraging feedback on their experience of combined problem-based learning and conventional teaching methods.
Use of computational fluid dynamics to study the influence of the uncinate process on nasal airflow
Authors: Xiong G-X , Zhan J-M , Zuo K-J , Rong L-W , Li J-F , Xu G 
Published: September 2010

AbstractBackground:Chronic rhinosinusitis is commonly treated by functional endoscopic sinus surgery involving excision of the uncinate process and opening of the osteomeatal complex.Methods:Computational fluid dynamics were used to compare nasal airflow after two different surgical interventions which involved opening the paranasal sinuses, excising the ethmoid sinus, and excising or preserving the uncinate process, in a cadaveric head model. Cross-sectional computed tomography images were obtained before and after the interventions. Imaging data were used to prepare computer simulations, which were used to assess the airflow characteristics of the nasal cavities and paranasal sinuses during inspiration and expiration, before and after intervention.Results:Significantly larger nasal cavity airflow velocity changes were apparent following the uncinate process excising procedure. Nasal cavity airflow distribution remained relatively unchanged following the uncinate process preserving procedure. There was a significantly greater increase in airflow volume following the uncinate process excising procedure, compared with the uncinate process preserving procedure.Conclusion:Preservation of the uncinate process may significantly reduce the alteration of nasal cavity airflow dynamics occurring after functional endoscopic sinus surgery for chronic rhinosinusitis.
Residual cervical lymphadenopathy after definitive treatment of nasopharyngeal carcinoma: fine needle aspiration cytology, computed tomography and histopathological findings
Authors: Toh S-T , Yuen H-W , Lim K-H , Goh Y-H , Goh H-K C 
Published: September 2010

AbstractBackground:Patients with nasopharyngeal carcinoma may have residual cervical lymphadenopathy after definitive treatment of the primary tumour and regional cervical nodal disease. Whether such lymphadenopathy truly represents persistent disease is unclear. There are few published studies addressing this clinical problem.Methods:We retrospectively and systematically reviewed the clinical records of 12 patients with nasopharyngeal carcinoma who had presented to a tertiary academic hospital, over an 11-year period, with suspected persistent cervical nodal disease after definitive radiotherapy or concurrent chemoradiotherapy. Findings on fine needle aspiration cytology and computed tomography scanning were correlated with final histopathological results.Results:The incidence of negative neck dissection was 41.7 per cent. The positive and negative predictive values of fine needle aspiration cytology in identifying disease were 100 and 42.9 per cent, respectively. Computed tomography scanning had a positive predictive value of 58.3 per cent in identifying disease.Conclusion:In patients treated definitively for nasopharyngeal carcinoma, residual cervical lymphadenopathy may not represent persistent disease. Head and neck surgeons involved in the management of these patients should bear in mind the current limitations of fine needle aspiration cytology and computed tomography in confirming the diagnosis pre-operatively. Salvage neck dissection may over-treat some of these patients.
Weakness of buccal branch of facial nerve after canine fossa puncture
Authors: Byun J Y , Lee J Y , Baek B J 
Published: September 2010

AbstractObjective:We report a case of weakness of the buccal branch of the facial nerve after a canine fossa puncture procedure.Method:A case report and literature review are presented.Results:A 52-year-old woman diagnosed with right chronic maxillary sinusitis underwent canine fossa puncture during endoscopic sinus surgery. Immediately after the operation, she complained of motor weakness of the right upper lip and oral commissure, in the area innervated by the buccal branch of the facial nerve. Electroneurography revealed incomplete paralysis of the right buccal branch. However, facial weakness had recovered spontaneously by three months post-operatively, with no permanent disability.Conclusion:This is the first reported case of an injury to the buccal branch of the facial nerve following canine fossa puncture. Although the incidence of this complication is very low, surgeons should inform their patients of the possibility, and should take care when choosing the puncture site.
Childhood sexual abuse and abnormal personality: a population-based study
Authors: Moran P. , Coffey C. , Chanen A. , Mann A. , Carlin J. B. , Patton G. C. 
Published: September 2010

BackgroundChildhood sexual abuse (CSA) has been shown to be a risk factor for personality disorder (PD). However, no previous studies have examined whether associations exist between sexual abuse and abnormal personality as measured both categorically and dimensionally. Such enquiry would more fully illuminate the impact of CSA on adult personality.MethodUsing a large nationally representative sample, we set out to examine associations between CSA and categorically defined PD. We also examined associations between CSA and the five dimensions of personality (openness to experience, conscientiousness, extraversion, agreeableness and neuroticism). A total of 1520 young adults were interviewed to determine the prevalence of sexual abuse occurring before age 16 years. A dimensional measure of personality was completed by 1469 participants, and 1145 had an informant-based PD assessment.ResultsPD was independently associated with repeated CSA [fully adjusted odds ratio (OR) 1.9, 95% confidence interval (CI) 1.1–3.4]. Repeated sexual abuse was also associated with higher neuroticism and lower agreeableness (p values for both <0.001). Adjusting for the effects of potential confounders and mediators, including earlier symptoms of anxiety and depression, had little impact on the strength of associations.ConclusionsWe conclude that repeated CSA is independently associated with categorically defined PD, and also with higher neuroticism and lower agreeableness. Our findings suggest that if a dimensional classification of PDs is adopted in future classification systems, there might be meaningful continuity with previous aetiological research conducted using the current categorical system.
A lightweight approach to datatype-generic rewriting
Authors: VAN NOORT THOMAS , RODRIGUEZ YAKUSHEV ALEXEY , HOLDERMANS STEFAN , JEURING JOHAN , HEEREN BASTIAAN , MAGALHÃES JOSÉ PEDRO 
Published: September 2010

AbstractTerm-rewriting systems can be expressed as generic programs parameterised over the shape of the terms being rewritten. Previous implementations of generic rewriting libraries require users to either adapt the datatypes that are used to describe these terms or to specify rewrite rules as functions. These are fundamental limitations: the former implies a lot of work for the user, while the latter makes it hard if not impossible to document, test, and analyze rewrite rules. In this article, we demonstrate how to overcome these limitations by making essential use of type-indexed datatypes. Our approach is lightweight in that it is entirely expressible in Haskell with GADTs and type families and can be readily packaged for use with contemporary Haskell distributions.
Non-pharmacological management of urinary incontinence
Authors: Mathur A , Browning J , Mistri AK 
Published: September 2010

SummaryUrinary incontinence is a common and under-reported symptom, affecting one in five people, with a higher prevalence in women and those who are elderly. It can have a major impact on physical health and social activity. Initial assessment to categorize symptom type is the key to guiding further therapy. Non-pharmacological (NP) options are preferred as first-line intervention, and if unsuccessful, are followed by anticholinergics, often in combination with NP options. Surgical intervention must be sought where appropriate. However, NP interventions are often not considered due to uncertainty about the evidence-base, perceived difficulty of application and perhaps a lack of awareness of or access to specialist continence services. This article addresses the first of the barriers, summarizing the evidence for various NP interventions, including lifestyle interventions, physical therapies, behavioural therapies and containment options, enabling the reader to formulate an evidence-based opinion and a pragmatic view on the feasibility, efficacy and applicability of the various NP interventions, without automatic recourse to anticholinergic medication in the first instance.
Losing a parent to cancer: A preliminary investigation into the needs of adolescents and young adults
Authors: Patterson Pandora , Rangganadhan Anita 
Published: September 2010

AbstractObjective:Research into parental loss has led to an understanding of the types of reactions and responses that children, and to a lesser extent adolescents and young adults, have when a parent dies. Only limited studies, however, have directly investigated the psychosocial needs of young people during this period. The aim of the current study was to identify and better understand the needs of adolescents and young adults who have lost a parent to cancer, and to ascertain the extent to which these needs had been met.Method:As the study is exploratory in nature, a qualitative questionnaire was used to explore the needs and unmet needs of adolescents and young adults who have had a parent die of cancer. Sixty-two parentally bereaved young people aged 12–23 participated.Results:The data were thematically analyzed and seven conceptually distinct need themes emerged, namely: support and understanding; help coping with feelings; to talk to people who have had a similar experience; information; have a break/have fun; space and time to grieve; and help with household responsibilities.Significance of results:The research findings will assist health professionals in developing services and interventions which are more responsive to the needs of parentally bereaved young people.
Factors influencing older adults to complete advance directives
Authors: Alano Gloria J. , Pekmezaris Renee , Tai Julia Y. , Hussain Mohammed J. , Jeune Jose , Louis Betina , El-Kass Gabriel , Ashraf Muhammad S. , Reddy Roopika , Lesser Martin , Wolf-Klein Gisele P. 
Published: September 2010

AbstractObjective:The purpose of this study was to determine the factors which influence advance directive (AD) completion among older adults.Method:Direct interviews of hospitalized and community-dwelling cognitively intact patients >65 years of age were conducted in three tertiary teaching settings in New York. Analysis of AD completion focused on its correlation with demographics, personal beliefs, knowledge, attitudes, and exposure to educational media initiatives. We identified five variables with loadings of at least 0.30 in absolute value, along with five demographic variables (significant in the univariate analyses) for multiple logistic regression. The backward elimination method was used to select the final set of jointly significant predictor variables.Results:Of the 200 subjects consenting to an interview, 125 subjects (63%) had completed ADs. In comparing groups with and without ADs, gender (p < 0.0002), age (p < 0.0161), race (p < 0.0001), education (p < 0.0039), and religion (p < 0.0104) were significantly associated with having an AD. Factors predicting AD completion are: thinking an AD will help in the relief of suffering at the end of life, (OR 76.3,p < 0.0001), being asked to complete ADs/ or receiving explanation about ADs (OR 55.2,p < 0.0001), having undergone major surgery (OR 6.3,p < 0.0017), female gender (OR 11.1,p < 0.0001) and increasing age (76–85vs.59–75: OR 3.4,p < 0.0543; <85vs. 59–75: OR 6.3,p < 0.0263).Significance of results:This study suggests that among older adults, the probability of completing ADs is related to personal requests by health care providers, educational level, and exposure to advance care planning media campaigns.
What makes grief difficult? Perspectives from bereaved family caregivers and healthcare providers of advanced cancer patients
Authors: Stajduhar Kelli I. , Martin Wanda , Cairns Moira 
Published: September 2010

AbstractObjective:Family members who take on the role of caregiving for someone who is dying begin bereavement after being emotionally and physically taxed by the caregiving experience. The course of bereavement is influenced by a number of factors, including health problems, financial concerns, social support, and family relationships. This paper reports on findings from a secondary analysis of qualitative data from a study examining family caregiver coping in end-of-life cancer care, to describe, from the perspectives of bereaved family caregivers, their perspectives on what made their grief difficult.Method:Qualitative data from three focus groups with family caregivers (n = 19) and two focus groups with health professionals (n = 14) were subjected to interpretive thematic analysis.Results:Our finding suggest three broad areas that make family caregivers' grief difficult: (1) dealing with occurrences in everyday life; (2) dealing with challenges specific to the caregiving situation; and (3) dealing with the healthcare system.Significance of results:The findings provide an important beginning point in understanding the types of issues that seem to make grief difficult for family caregivers of cancer patients at the end of life and can help professional groups to understand what is needed by family caregivers in terms of support and delivery of services.