bluuebunny/crossref_metadata_2025_split huggingface dataset:
AcrySof Cachet Phakic Intraocular Lens in Myopic Patients: Visual Performance, Wavefront Error, and Lens Position
Authors: Mastropasqua Leonardo , Toto Lisa , Vecchiarino Luca , Doronzo Emanuele , Mastropasqua Rodolfo , Di Nicola Marta 
Published: March 2012

PURPOSE:
To evaluate visual and aberrometric outcomes and position of the AcrySof Cachet (Alcon Laboratories Inc) angle-supported phakic intraocular lens (PIOL) for correction of myopia in adults.

METHODS:
This prospective study included 36 consecutive eyes with moderate to high myopia in which an AcrySof Cachet PIOL was implanted to minimize refractive error. Follow-up was up to 1 year.

RESULTS:

Mean manifest spherical equivalent refraction reduced significantly from −14.90±0.90 diopters (D) to −0.29±0.30 D at 1 month and remained stable at 1 year (
P
<.001). Mean uncorrected distance visual acuity was ⩾0.1 logMAR (20/20 Snellen) in 56% of patients and ⩾0.3 logMAR (20/25 Snellen) in 100% of patients. Corrected distance visual acuity was ⩾0.1 logMAR (20/20 Snellen) in 78% of patients and ⩾0.3 logMAR (20/25 Snellen) in 100% of patients. Mean endothelium–PIOL distance and mean PIOL–crystalline distance were within recommended values at all postoperative evaluations. Statistically significant variations for these variables were not observed. Anterior chamber depth, safety center distance, and vault center distance showed significant reduction after accommodation (
P
<.01). Anterior chamber depth and safety center distance significantly increased after pupil dilation (
P
⩽.01). Mean percentage of endothelial cell loss was 4.04% at 1 year. The root-mean-square of total higher order aberrations and spherical, coma, and trefoil aberrations did not change significantly from pre- to postoperatively.

CONCLUSIONS:
The AcrySof Cachet PIOL was effective in the correction of moderate to high myopia and provided excellent visual performance with no modification of physiologic ocular wavefront error. Adequate distance from the cornea and crystalline lens was maintained with no significant change during follow-up and under different environmental conditions.
La photographie, un outil pour communiquer en classe de langue
Authors: Muller Catherine 
Published: March 2012

Cette contribution, qui relève de la didactique des langues, s’appuie sur l’analyse des interactions verbales et de la communication en classe de langue. Elle repose sur la capacité de l’image à susciter des productions verbales. La photographie d’auteur est ici considérée comme un déclencheur d’interactions orales permettant de communiquer. Nous avons mis en œuvre une tâche dans des cours de français langue étrangère en contexte pluriculturel à Paris avec des apprenants de niveaux A1 à B2. Le projet mené en groupe consiste à commenter des photographies d’auteur sans objectifs langagiers prédéterminés. L’analyse d’une séquence recueillie devant la photographie Rue Mouffetard d’H. Cartier-Bresson révèle l’importance de la communication entre les apprenants. La photographie suscite des enjeux communicatifs qui favorisent l’implication des étudiants. Ces derniers prennent position sur l’image et sont amenés à confronter leurs points de vue avec leurs pairs. Les apprenants peuvent également avoir recours à l’humour et modifier leur rôle conversationnel habituel.
Discours métaphorique et monnaies : les particularités de l’euro
Authors: Resche Catherine 
Published: March 2012

Partant du constat que la langue de l’économie contient bon nombre de métaphores, nous nous sommes attachée à étudier plus particulièrement le domaine des monnaies afin de rendre compte de la spécificité du discours sur l'euro et d’affiner une analyse ébauchée à l’occasion d’une approche de la néologie autour de la monnaie unique. Un rappel des notions fondamentales concernant la métaphore en général nous a semblé indispensable pour mieux situer le cadre de notre étude : les questions de sémiotique et de sémantique, de lexicalisation de la métaphore et de métaphore d’invention, ainsi que les différentes fonctions de la métaphore sont abordées. Puis, nous avons passé en revue les registres métaphoriques le plus fréquemment utilisés pour parler des monnaies en général, avant d’examiner le cas de l’euro, et d’essayer d’en faire ressortir la spécificité, en insistant sur les domaines d’emprunt qui caractérisent son discours. Enfin, nous avons tenté d’analyser ce discours et de montrer comment les métaphores peuvent se révéler source précieuse de renseignements sur une période donnée et comment le message qu’elles véhiculent peut devenir instructif quant aux opinions de ses auteurs et de ses destinataires.
Upregulated Protein Arginine Methyltransferase 1 by IL-4 Increases Eotaxin-1 Expression in Airway Epithelial Cells and Participates in Antigen-Induced Pulmonary Inflammation in Rats
Authors: Sun Qingzhu , Yang Xudong , Zhong Bo , Jiao Fangfang , Li Chenyan , Li Dongmin , Lan Xi , Sun Jian , Lu Shemin 
Published: March 2012

Abstract
Protein arginine methyltransferases (PRMTs), catalyzing methylation of both histones and other cellular proteins, have emerged as key regulators of various cellular processes. This study aimed to identify key PRMTs involved in Ag-induced pulmonary inflammation (AIPI), a rat model for asthma, and to explore the role of PRMT1 in the IL-4–induced eosinophil infiltration process. E3 rats were i.p. sensitized with OVA/alum and intranasally challenged with OVA to induce AIPI. The expressions of PRMT1–6, eotaxin-1, and CCR3 in lungs were screened by real-time quantitative PCR. Arginine methyltransferase inhibitor 1 (AMI-1, a pan-PRMT inhibitor) and small interfering RNA–PRMT1 were used to interrupt the function of PRMT1 in A549 cells. In addition, AMI-1 was administrated intranasally to AIPI rats to observe the effects on inflammatory parameters. The results showed that PRMT1 expression was mainly expressed in bronchus and alveolus epithelium and significantly upregulated in lungs from AIPI rats. The inhibition of PRMTs by AMI-1 and the knockdown of PRMT1 expression were able to downregulate the expressions of eotaxin-1 and CCR3 with the IL-4 stimulation in the epithelial cells. Furthermore, AMI-1 administration to AIPI rats can also ameliorate pulmonary inflammation, reduce IL-4 production and humoral immune response, and abrogate eosinophil infiltration into the lungs. In summary, PRMT1 expression is upregulated in AIPI rat lungs and can be stimulated by IL-4. Intervention of PRMT1 activity can abrogate IL-4–dependent eotaxin-1 production to influence the pulmonary inflammation with eosinophil infiltration. The findings may provide experimental evidence that PRMT1 plays an important role in asthma pathogenesis.
The Bluejay Genome Browser
Authors: Soh Jung , Gordon Paul M.K. , Sensen Christoph W. 
Published: March 2012

AbstractThe Bluejay genome browser is a stand‐alone visualization tool for the multi‐scale viewing of annotated genomes and other genomic elements. Bluejay allows users to customize display features to suit their needs, and produces publication‐quality graphics. Bluejay provides a multitude of ways to interrelate biological data at the genome scale. Users can load gene expression data into a genome display for expression visualization in context. Multiple genomes can be compared concurrently, including time series expression data, based on Gene Ontology labels. External, context‐sensitive biological Web Services are linked to the displayed genomic elements ad hoc for in‐depth genomic data analysis and interpretation. Users can mark multiple points of interest in a genome by creating waypoints, and exploit them for easy navigation of single or multiple genomes. Using this comprehensive visual environment, users can study a gene not just in relation to its genome, but also its transcriptome and evolutionary origins. Written in Java, Bluejay is platform‐independent and is freely available from http://bluejay.ucalgary.ca. Curr. Protoc. Bioinform. 37:10.9.1‐10.9.23. © 2012 by John Wiley & Sons, Inc.
Effects of the Morphology of a ZnO Buffer Layer on the Photovoltaic Performance of Inverted Polymer Solar Cells
Authors: Liang Zhiqiang , Zhang Qifeng , Wiranwetchayan Orawan , Xi Junting , Yang Zhou , Park Kwangsuk , Li Chundong , Cao Guozhong 
Published: March 2012

AbstractThe influences of morphology and thickness of zinc oxide (ZnO) buffer layers on the performance of inverted polymer solar cells are investigated. ZnO buffer layers with different morphology and thickness varying from several nanometers to ≈55 nm are fabricated by adjusting the concentration of the precursor sol. The ZnO buffer layers with nearly same surface quality but with thickness varying from ≈7 to ≈65 nm are also fabricated by spinning coating for comparison. The photovoltaic performance is found to be strongly dependent on ZnO surface quality and less dependent on the thickness. The use of dense and homogenous ZnO buffer layers enhances the fill factor and short‐circuit current of inverted solar cell without sacrificing the open‐circuit voltage of device due to an improvement in the contact between the ZnO buffer layer and the photoactive layer. Inverted devices with a dense and homogenous ZnO buffer layer derived from 0.1 M sol exhibit an overall conversion efficiency of 3.3% which is a 32% increase compared to devices with a rough ZnO buffer layer made from 1 M sol, which exhibited a power conversion efficiency of 2.5%. The results indicate that the efficiency of inverted polymer solar cells can be significantly influenced by the morphology of the buffer layer.
Universal Polarization Switching Behavior of Disordered Ferroelectrics
Authors: Genenko Yuri A. , Zhukov Sergey , Yampolskii Sergey V. , Schütrumpf Jörg , Dittmer Robert , Jo Wook , Kungl Hans , Hoffmann Michael J. , von Seggern Heinz 
Published: March 2012

AbstractUniversal scaling features of polarization switching are established experimentally in rather different classes of disordered ferroelectrics: in well‐studied lead‐zirconate titanate (PZT) ferroelectrics, in recently synthesized Cu‐stabilized 0.94(Bi1/2Na1/2)TiO3–0.06BaTiO3 (BNT‐BT) relaxor ferroelectrics, and in classical organic ferroelectrics P(VDF‐TrFE). These scaling properties are explained by an extended concept of an inhomogeneous field mechanism (IFM) of polarization dynamics in ferroelectrics. Accordingly, disordered ferroelectrics exhibit a wide spectrum of characteristic switching times due to a statistical distribution of values of the local electric field. How this distribution can be extracted from polarization measurements is demonstrated. Generally, it is shown that the polarization response is primarily controlled by the statistical characteristics of disorder rather than by a temporal law of the local polarization switching.
2010 McDonald criteria for diagnosing pediatric multiple sclerosis
Authors: Sadaka Yair , Verhey Leonard H. , Shroff Manohar M. , Branson Helen M. , Arnold Douglas L. , Narayanan Sridar , Sled John G. , Bar‐Or Amit , Sadovnick A. Dessa , McGowan Melissa , Marrie Ruth Ann , Banwell Brenda ,   on behalf of the Canadian Pediatric Demyelinating Disease Network
Published: March 2012

AbstractObjective:The diagnosis of multiple sclerosis (MS) rests on confirmation of central nervous system inflammatory disease that is disseminated in space and time, as evidenced clinically or by magnetic resonance imaging (MRI). The 2010 McDonald criteria simplified MRI requirements, and newly proposed that the criteria are also suitable for the diagnosis of pediatric MS.Methods:In a national prospective incident cohort study of children with acute demyelination observed for a minimum of 24 months, baseline and serial clinical and MRI examinations were used to retrospectively evaluate the 2010 and 2005 McDonald criteria using clinically relapsing disease as the gold standard.Results:Of 212 eligible participants, 34 experienced 2 or more clinical attacks, 58 met the 2010 criteria, and 42 met 2005 McDonald criteria. The 2010 criteria demonstrated high sensitivity (100%), specificity (86%), positive predictive value (76%), and negative predictive value (100%) for children older than 11 years with non–acute disseminated encephalomyelitis (ADEM) presentations, as did the 2005 McDonald criteria. In younger children with a non‐ADEM presentation, PPV of the 2010 criteria was only 55%. None of the 50 children with ADEM met clinical criteria for MS, but 10 met 2010 and 4 met 2005 criteria.Interpretation:Both 2005 and 2010 McDonald criteria identify children with relapsing–remitting MS, although caution is suggested when applying these criteria in younger children. The 2010 McDonald criteria are simple and enable an early diagnosis of MS, but are not suited for application in the context of ADEM‐like presentations. ANN NEUROL 2012;72:211–223.
Strong Nuclear Ring Currents and Magnetic Fields in Pseudorotating OsH4 Molecules Induced by Circularly Polarized Laser Pulses
Authors: Barth Ingo , Bressler Christian , Koseki Shiro , Manz Jörn 
Published: March 2012

AbstractWe design a circularly polarized laser pulse in the infrared frequency and femtosecond time domains, for excitation of the OsH4 molecule in its first excited pseudorotational state of the triply‐degenerate bend. The OsH4 molecule need not be pre‐oriented. After excitation, the central nucleus Os carries out pseudorotation about the axis parallel to the direction of propagation of the laser pulse. This pseudorotation causes a strong electric ring current with a value I=1.53 e fs−1. The mean value of the radius of the ring current is very small, R=0.0031 a0, where a0 is the Bohr radius. According to the Biot–Savart law (|${{\vec{\bf B}}}$(R=0)|∼I/R), this nuclear ring current induces the strongest magnetic field predicted so far in molecules, with a central peak absolute value |${{\vec{\bf B}}}$(R=0)|=623 T. To monitor the effect, we propose an IR‐pump–X‐ray‐probe versus an X‐ray‐probe‐only experiment, at the K‐ and L‐edges of X‐ray ionization. The results are based on the general quantum theory of excitations of pseudorotations in tetrahedral molecules AB4, driven by a circularly polarized laser pulse.
Aminopyrrolic Synthetic Receptors for Monosaccharides: A Class of Carbohydrate‐Binding Agents Endowed with Antibiotic Activity versus Pathogenic Yeasts
Authors: Nativi Cristina , Francesconi Oscar , Gabrielli Gabriele , De Simone Irene , Turchetti Benedetta , Mello Tommaso , Mannelli Lorenzo Di Cesare , Ghelardini Carla , Buzzini Pietro , Roelens Stefano 
Published: March 2012

AbstractThe biological activity of a set of structurally related aminopyrrolic synthetic receptors for monosaccharides has been tested versus yeast and yeast‐like microorganisms and compared to their binding affinity toward mannosides. Antibiotic activity comparable to that of well‐known polyene (amphotericin B) or azole (ketoconazole) drugs has been found for some members of the family, along with a general correlation with binding abilities. A systematic structure–activity–affinity investigation shed light on the structural and functional requirements necessary for antibiotic activity and identified the tripodal compound 1 as the most potent compound of the set. Together with toxicity tests and inhibitor localization experiments performed through fluorescence microscopy, these studies led to the characterization of a new class of carbohydrate binding agents possessing antibiotic activity, in which pyrrolic groups precisely structured on a tripodal architecture appear to be responsible for permeability through the cell wall of pathogens, as well as for antibiotic activity inside the cytoplasm.
Spin–Spin Artificial DNA Intercalated with Silver Cations: Theoretical Prediction
Authors: Kauch Małgorzata , Pecul Magdalena 
Published: March 2012

AbstractThe indirect nuclear spin–spin coupling constants of Ag+ cation intercalated between imidazole rings in DNA chains are calculated by means of DFT with relativistic effects taken into account by the use of the zeroth‐order regular approximation Hamiltonian (DFT‐ZORA). The calculations model how the 1J(15N,109Ag) coupling constant is affected by different types of geometry deformations and by the presence of water, which is simulated by means of the polarizable continuum model and explicitly present water molecules. Calculations for systems containing two and three imidazole pairs are also carried out to model the influence of stacking interactions. The computed 1J(15N,109Ag) spin–spin coupling constant is in the range of 85–105 Hz (depending on the computational model) and is in good agreement with the experimental value (ca. 92 Hz). This coupling constant is very little affected by the presence of solvent, stacking interactions, and geometry deformations. Such behavior is explained by visualization of the coupling path by means of coupling energy density (CED). Bigger models allow the coupling constant between two adjacent silver ions to be computed, and give a value of approximately 1 Hz, which is probably too small to be of practical interest. The 2J(15N,15N) value is calculated to be about 2.5 Hz, and is therefore of measurable magnitude.
Theoretical Insights into Chirality‐Controlled SWCNT Growth from a Cycloparaphenylene Template
Authors: Li Hai‐Bei , Page Alister J. , Irle Stephan , Morokuma Keiji 
Published: March 2012

AbstractA self‐assembly mechanism for low‐temperature SWCNT growth from a [6]cycloparaphenylene ([6]CPP) precursor via ethynyl (C2H) radical addition is presented, based on non‐equilibrium quantum chemical molecular dynamics (QM/MD) simulations and density functional theory (DFT) calculations. This mechanism, which maintains the (6,6) armchair chirality of a SWCNT fragment throughout the growth process, is energetically more favorable than a previously proposed Diels–Alder‐based growth mechanisms [E. H. Fort, et al., J. Mater. Chem. 2011, 21, 1373]. QM/MD simulations and DFT calculations show that C2H radicals play dual roles during SWCNT growth, by abstracting hydrogen from the SWCNT fragment and providing the carbon source necessary for growth itself. Simulations demonstrate that chirality‐controlled SWCNT growth from macrocyclic hydrocarbon seed molecules with pre‐selected edge structure can be accomplished when the reaction conditions are carefully selected for hydrogen abstraction by radical species during the growth process.
Influence of the Acetylenic Substituent on the Intramolecular Carbolithiation of Alkynes
Authors: Girard Anne‐Lise , Lhermet Rudy , Fressigné Catherine , Durandetti Muriel , Maddaluno Jacques 
Published: March 2012

AbstractThe intramolecular carbolithiation of a series of propargylic ethers has been performed to evaluate the influence of the terminal substituent on the efficiency and the stereochemical outcome of the cyclization. Our results show that only 5‐exo‐dig cyclizations are observed, and dihydrobenzofurans are obtained exclusively. Depending on the nature of the terminal substituent, two cases can be considered. If the terminal substituent carried by the acetylenic carbon atom is itself a carbon atom, the cyclization can occur provided the terminal propargylic position bears a coordinating element and is at least disubstituted. When the cyclization occurs, it follows an anti‐carbolithiation pathway and thus leads to the E isomer of the exocyclic double bond. Only in one case (Ph) was a mixture of the E and Z isomers of the resulting olefin recovered. The cyclization can also take place if the alkyne is directly substituted by S or Si, provided the cyclization conditions are tuned. In the case of the trimethylsilyl substituent, a syn‐carbolithiation was observed. If the double bond is recovered, in most cases, in the exocyclic position, the products can aromatize directly for SPh‐substituted substrate 24. Furthermore, in the two latter cases, when alkylation of the vinyllithium intermediate is performed, isomerization of the double bond seems instantaneous.
Hapmap‐based evaluation of ERCC2, PPP1R13L, and ERCC1 and lung cancer risk in a Chinese population
Authors: Yin Jiaoyang , Vogel Ulla , Wang Chunhong , Liang Duohong , Ma Yegang , Wang Huiwen , Yue Li , Liu Donghui , Ma Jian , Sun Xiaoling 
Published: March 2012

AbstractA genomic region on chromosome 19q13.3 has been associated with cancer susceptibility. A Chinese case–control study including 339 lung cancer cases and 358 controls was conducted using haplotype‐tagging SNP (htSNP) approach and HapMap database to evaluate the role of this locus. Four htSNPs (rs6966, rs2070830, rs4802252, and rs4803817) representing 95% of the common variations in PPP1R13L, as well as fourteen htSNPs encompassing ERCC2, PPP1R13L, and ERCC1 on chromosome 19q13.3 were explored. Three haplotype blocks of strong linkage disequilibrium were identified. Overall, no single htSNP or haplotype associations were found for PPP1R13L. Highly significant differential distributions of haplotypes defined by both nine htSNPs covering ERCC2 and PPP1R13L and fourteen htSNPs covering ERCC2, PPP1R13L, and ERCC1 were found (global test P = 8.12e−005 and P = 4.82e−006, respectively). The results indicate that the biologically relevant genetic variation may be located at or near the subregion spanning from ERCC2 inton19 rs1799787 to PPP1R13L intron8 rs2070830. Environ. Mol. Mutagen., 2012. © 2012 Wiley Periodicals, Inc.
Seismic response of a cut‐and‐cover tunnel isolated by polymer material
Authors: Kiryu Satoshi , Murono Yoshitaka , Morikawa Hitoshi 
Published: March 2012

SUMMARYAn effective method for the seismic retrofitting of the sidewalls of cut‐and‐cover tunnels has not yet been established. Thus, a new method of seismic retrofitting for cut‐and‐cover tunnels, called the ‘polymer isolation method’, is developed here. In this method, thin walls made of polymer materials, called ‘isolation walls’, are inserted between the ground and the sidewalls of a tunnel. We demonstrate the effectiveness of the proposed method in reducing the seismic response of tunnels by using some numerical simulations. It is found that the proposed method depends on the thickness of the soil cover over the tunnel and the ratio of the stiffness between the soil and the structure. Furthermore, a simple chart is proposed for convenience to represent the applicability of the polymer isolation method to the design of seismic retrofits for cut‐and‐cover tunnels. Although this particular chart has been obtained through a limited case, some other typical cases in which the chart can also be implemented for special conditions are addressed, and the applicability and the limitations of this chart are suggested for possible conditions of the ground and of tunnel structures. Copyright © 2012 John Wiley & Sons, Ltd.