bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early assessment of infarct size and prediction of functional recovery by quantitative myocardial blush grade in patients with acute coronary syndromes treated according to current guidelines
Authors: Riedle Nina , Dickhaus Hartmut , Erbacher Markus , Steen Henning , Andrassy Martin , Lossnitzer Dirk , Hardt Stefan , Rottbauer Wolfgang , Zugck Christian , Giannitsis Evangelos , Katus Hugo A. , Korosoglou Grigorios 
Published: March 2010

AbstractPurpose: To determine whether quantification of myocardial blush grade (MBG) during cardiac catheterization can aid the determination of follow‐up left ventricular (LV)‐function in patients with ST‐elevation and non‐ST‐elevation myocardial infarction (STEMI and NSTEMI). Methods: We prospectively examined patients with first STEMI (n = 46) and NSTEMI (n = 49). ECG‐gated angiographic series were used to quantify MBG by analyzing the time course of contrast agent intensity rise. Hereby, the parameter Gmax/Tmax was calculated, derived from the plateau of grey‐level intensity (Gmax), divided by the time‐to‐peak intensity (Tmax). Cardiac magnetic resonance imaging (CMR) deemed as the standard reference for the estimation of infarct size, transmurality and of the LV‐function at 6 months of follow‐up. Results: Cut‐off values of Gmax/Tmax=5.7/sec and 3.8/sec, respectively, yielded similar accuracy as infarct transmurality for the prediction of follow‐up ejection fraction >55% (AUC = 0.86 for STEMI and AUC = 0.90 for NSTEMI, by Gmax/Tmax and AUC = 0.85 for STEMI and AUC = 0.89 for NSTEMI, by infarct transmurality, respectively, P = NS). Both clearly surpassed the predictive value of visual MBG (AUC = 0.69 for STEMI and AUC = 0.68 for NSTEMI, P < 0.05). Conclusion: Gmax/Tmax is an easy to acquire but highly valuable surrogate parameter for infarct size, which yields equally high accuracy with infarct transmurality and favorably compares with visually assessed blush grades for the prediction of follow‐up LV‐function in patients with acute ischemic syndromes. © 2010 Wiley‐Liss, Inc.
Transcatheter treatment of “complex” aortic coarctation
Authors: Santoro Giuseppe , Qureshi Shakeel , Russo Maria Giovanna 
Published: March 2010

AbstractA young woman, submitted to aortic coarctation repair in early infancy, was referred with clinical and echocardiographic signs of severe recoarctation. Spiral CT scan confirmed the aortic isthmus obstruction but imaged also a huge aneurysm distal to the coarctation site, from which arose a large aberrant right subclavian artery. In cardiac catheterization, this vessel showed an upper‐to‐lower flow direction and its closure was deemed mandatory to abolish a major feeding source to the aneurysmal sack. Thus, this anomalous vessel was occluded with an Amplatzer Duct Occluder device and multiple covered Cheatham‐Platinum stents were telescopically implanted into the thoracic aorta to dilate the coarctation and exclude the aneurysm. In conclusion, percutaneous transcatheter treatment is feasible, safe, and cost‐effective even in aortic arch obstructions with complex anatomic arrangement. © 2010 Wiley‐Liss, Inc.
Angioplasty of ulnar or radial arteries to treat critical hand ischemia: Use of 3‐ and 4‐French Systems
Authors: Kawarada Osami , Yokoi Yoshiaki , Higashimori Akihiro 
Published: March 2010

AbstractObjectives: The aim of this preliminary study is to report the results of catheter‐based treatment for isolated distal upper extremity artery disease with CHI. Background: Critical hand ischemia (CHI) is a rare but potentially devastating condition. Methods: The study consisted of five critically ischemic hands (Rutherford category 4: 2, Rutherford category 5: 3) in four patients undergoing catheter intervention for isolated distal upper extremity artery disease between November 2007 and April 2009. Results: Balloon angioplasty via an antegrade brachial approach was performed with a 3Fr or 4Fr sheath to achieve the principal endpoint of the establishment of one straight‐line flow to the palmar arch. All patients had end‐stage renal disease requiring chronic hemodialysis. The target vessels were the ulnar artery in four cases, the radial artery in one, and the palmar arch in two. Four cases had a stenotic lesion and one had chronic total occlusion. Technical success was achieved in all cases without complications, and skin perfusion pressure of the hand improved significantly from 39 ± 20 to 52 ± 16 (P = 0.019) on the palmar side and from 40 ± 18 to 60 ± 29 on the dorsal side (P = 0.046). Clinical success was achieved in all cases during a mean follow‐up period of 11 ± 8 (2–19) months. Conclusions: Percutaneous angioplasty using contemporary dedicated devices could be a potentially useful option for CHI patients with isolated distal upper extremity artery disease. © 2010 Wiley‐Liss, Inc.
Mitral valve repair with the MitraClip device after prior surgical mitral annuloplasty
Authors: Lim D. Scott , Kunjummen Binu J. , Smalling Richard 
Published: March 2010

AbstractWhile mitral valve repair using the MitraClip device is currently being evaluated in the EVEREST trials, surgical approaches to mitral regurgitation remain the standard of care, at least for operative candidates. Two patients in whom previous surgical annuloplasty failed to maintain MR reduction and who were treated with the MitraClip device after mitral valve repair surgery are described. Imaging and hemodynamic considerations associated with this approach are discussed. © 2010 Wiley‐Liss, Inc.
Transthoracic echocardiographic assistance for interatrial stenting in low birth‐Weight neonates with hypoplastic left heart syndrome and intact atrial septum
Authors: Petit Christopher J. , Altman Carolyn A. , Pignatelli Ricardo H. 
Published: March 2010

AbstractInfants with hypoplastic left heart syndrome and intact or highly restrictive atrial septum require emergent therapy to relieve pulmonary congestion. Transcatheter stenting has become, in most large centers, the mainstay of therapy for relief of left atrial hypertension. Normally, this procedure is performed with the assistance of transesophageal echocardiographic guidance. However, the transesophageal approach is untenable in neonates of low birth weight, as the transducers can be traumatic and can cause ventilatory difficulty. We present two cases in which transthoracic echocardiographic guidance was used to guide atrial perforation and stenting in low birth‐weight neonates with hypoplastic left heart syndrome with intact or highly restrictive atrial septum. Both procedures were straightforward and there were no complications. Real‐time biplane imaging greatly assisted in the intervention in one case. The advantages of this approach are discussed. © 2010 Wiley‐Liss, Inc.
Reduction in spasm with a long hydrophylic transradial sheath
Authors: Caussin Christophe , Gharbi Mostari , Durier Chloé , Ghostine Saïd , Pesenti‐Rossi David , Rahal Saliha , Brenot Philippe , Barri Maruan , Durup Florence , Lancelin Bernard 
Published: March 2010

AbstractObjectives: We aimed to assess the efficiency of a long hydrophilic sheath in reducing radial spasm for transradial approach. Background: Despite a lower access site complication rate, cardiac catheterization using transradial approach is not widely used. Radial spasm is one of the main issues for transradial angiography and percutaneous interventions. We assumed that radial artery protection using a long hydrophilic‐coated sheath would reduce radial spasm compared to a bare short sheath. Methods: Three hundred and fifty one patients (pts) admitted for transradial coronary angiography ± percutaneous coronary interventions were randomly assigned to a long hydrophilic‐coated or a short sheath (control group). Primary end point was the occurrence of a radial spasm defined by significant patient pain evaluated by scale score (>4) or significant catheter frictions during manipulation. Procedure failure, radial occlusion, and local complications were also assessed. Results: Radial spasm was significantly reduced when using the long‐coated compared to the short sheath in 7 (4%) vs. 32 pts (18%) P < 0.001. No difference was found regarding procedure failure respectively 1.2% vs. 0.6%, local complication 0.6% vs. 1.2%, and radial occlusion 3.5% vs. 3.5%. Conclusion: Radial artery protection using the long hydrophilic‐coated sheath was efficient in the prevention of radial spasm for transradial approach. © 2010 Wiley‐Liss, Inc.
Migration of covered stents from hemodialysis A‐V access to the pulmonary artery: Percutaneous stent retrieval and procedural trends
Authors: Dashkoff Neil , Blessios George A. , Cox Matthew R. 
Published: March 2010

AbstractDetails are presented of two patients with end‐stage renal disease (ESRD) who recently experienced migration of a Viabahn covered stent from a peripheral hemodialysis A‐V access to the right lower lobe pulmonary artery. Successful percutaneous retrieval was achieved in one patient using a dual snare approach, facilitated by ex vivo product testing. The second patient was managed conservatively. A review of the institution's A‐V access salvage procedures, indicated a concomitant trend toward greater use of stent‐assisted procedures, and a higher utilization of covered versus uncovered stents. © 2010 Wiley‐Liss, Inc.
Lung perfusion studies after transcatheter closure of persistent ductus arteriosus with the Amplatzer duct occluder
Authors: Polat Tugcin Bora , Celebi Ahmet , Hacımahmutoglu Sevim , Akdeniz Celal , Erdem Abdullah , Fırat Fatih 
Published: March 2010

AbstractBackground: Reduced left lung perfusion has been described after transcatheter closure of the patent ductus arteriosus (PDA) with several prostheses. Although the Amplatzer ductal occluder (ADO) device is currently the most widely used occluder for closure of large‐sized PDAs, the potential consequences of flow distribution to the lungs of this device have not been completely clarified. We evaluated lung perfusion following occlusion of PDA with the ADO device. Methods: Forty‐seven patients underwent successful transcatheter PDA occlusion using the ADO device were included in this study. Lung perfusion scans were performed 6 months after the procedure. Results: Decreased perfusion to the left lung (defined as < 40% of total lung flow) was observed in 17 patients (36%), 5 of whom were low‐weight symptomatic infants. Ductal ampulla length was significantly shorter and minimal ductal diameter to ampulla diameter ratio was significantly higher in patients with decreased left lung perfusion and correlated well with left lung perfusion values (r = 0.516 and r = −0.501, respectively). A cut‐off value of ≤5.8 mm for the ductal ampulla length and ≥1.9 for ampulla diameter to ampulla length ratio showed high sensitivity and specificity for reduced lung perfusion. Conclusions: The incidence of abnormal left lung perfusion is high 6 months after transcatheter closure of PDA with the ADO, more likely in the low weight symptomatic infants and in patients with a short duct or a relatively shallow duct having abrupt narrowing of a large ampulla. © 2010 Wiley‐Liss, Inc.
Percutaneous intervention of left main coronary artery compression by pulmonary artery aneurysm
Authors: Vaseghi Marmar , Lee Michael S. , Currier Jesse , Tobis Jonathan , Shapiro Shelley , Aboulhosn Jamil 
Published: March 2010

AbstractBackground: Extrinsic compression of the left main coronary artery (LMCA) by a pulmonary artery aneurysm (PAA) has become increasingly recognized as an etiology of angina in patients with pulmonary arterial hypertension (PAH). The purpose of this study was to assess the feasibility and efficacy of LMCA stenting in the treatment LMCA stenosis because of PAA. Methods: Retrospective analysis of data on patients with PAH who presented with angina and underwent percutaneous intervention of their LMCA compression because of PAA was performed. Results: Five patients (age 51 ± 16 years, all female) with PAH presented with angina and underwent LMCA stenting between 2007 and 2009. Four had positive cardiac enzymes. LMCA compression because of a PAA was diagnosed in all patients with cardiac CT angiography after echocardiography demonstrated an enlarged pulmonary artery. LMCA stenting was successfully performed in all patients with resolution of angina and electrocardiographic abnormalities. After a mean follow‐up of 16.6 ± 15.7 months (range of 5–39 months), patients remained angina free, no complications of the procedure were noted, and long term stent patency was confirmed in three of the five patients who underwent repeat cardiac CT angiography. Conclusions: LMCA stenting appears to be a feasible and durable option in patients who present with angina because of compression by PAA. This procedure was well tolerated and is of particular value given the increased surgical risk in patients with PAH. © 2010 Wiley‐Liss, Inc.
A new dedicated ultrashort steerable balloon for side branch ostial dilatation
Authors: Secco Gioel Gabrio , Di Mario Carlo 
Published: March 2010

AbstractA dedicated balloon with a short beveled tip and the ability to rotate it from the proximal hub was successfully used to dilate the origin of a side branch which became totally occluded after deployment of a stent in the main vessel. Although regular low profile balloons are mostly successful in crossing struts of previously deployed stents, this new device has the potential to offer a more predictable and rapid solution in routine practice. © 2010 Wiley‐Liss, Inc.
Comparative Study of Copper‐ and Silver‐Catalyzed Protodecarboxylations of Carboxylic Acids
Authors: Gooßen Lukas J. , Rodríguez Nuria , Linder Christophe , Lange Paul P. , Fromm Andreas 
Published: March 2010

AbstractThe protodecarboxylation of aromatic carboxylic acids by various copper and silver catalysts is investigated with the help of density functional calculations and experimental studies. The computational results reveal that the catalytic activity of copper(I)–1,10‐phenanthroline catalysts increases with the introduction of electron‐rich substituents at the phenanthroline ligand. They also predicted that for some substrates, silver complexes should possess a substantially higher decarboxylating activity than copper, which is confirmed by experimental studies, leading to the discovery of a silver(I) catalyst that effectively promotes the protodecarboxylation of various carboxylic acids at temperatures in the range of 80–120 °C—more than 50 °C below those of the best known copper(I) catalyst. The scope of the new system complements that of the copper(I)‐based method as it includes benzoates for example, with halogen or ether groups in the ortho positions.
Gold‐Catalyzed Cross‐Couplings: New Opportunities for CC Bond Formation
Authors: Garcia Pierre , Malacria Max , Aubert Corinne , Gandon Vincent , Fensterbank Louis 
Published: March 2010

AbstractCross‐coupling is a powerful tool for the rapid construction of highly valuable compounds. In this area of chemical transformations, new catalysts have recently emerged. Combining both a π‐Lewis acid character and interesting redox properties, gold has proven to be an expedient choice for mediating such transformations. Recent developments in the use of gold to mediate a variety of CC coupling reactions are summarized, including Suzuki and Sonogashira cross‐coupling reactions, as well as the development of tandem processes and the combination of gold with palladium to enable CC bond formation via transmetalation.
Disjoint hard models for classification
Authors: Li Dong , Lloyd Gavin R , Duncan John C , Brereton Richard G 
Published: March 2010

AbstractThe paper describes a new approach for disjoint hard modelling of classes. This involves developing independent PC models for each group in the class, and calculating both the Q statistic (square prediction error) for each sample to the class model and a separate statistic about how well samples are classified within the projected PC space. The latter statistic can be applied to different types of classifiers, in this paper we choose to illustrate by Quadratic Discriminant Analysis (D statistic) and one class Support Vector Domain Description (SVDD) (f‐value). The two measures (Q and the classifier dependent statistic) are combined into a joint decision function which uniquely classifies each sample. The disjoint hard models are contrasted to conjoint models where PCA is performed on the entire dataset using both QDA and Support Vector Machines (SVMs) classifiers. The optimum number of PCs for each model is determined using the bootstrap, and model performance assessed on 100 test sets obtained using different iterative splits, using %PA (Predictive Ability) and %CR (Classification Rate). The method is illustrated using a dataset consisting of 293 samples from nine groups of polymers obtained using thermal profiling. The approach described, in this paper, has many of the advantages of one class disjoint models (e.g. SIMCA) and of conventional hard models, and is useful if it is known that all samples must belong to one of a series of known groups but each group has a very different structure. Copyright © 2010 John Wiley & Sons, Ltd.
Synthesis, Magnetic Properties, and STM Spectroscopy of Cobalt(II) Cubanes [CoII4(Cl)4(HL)4]
Authors: Scheurer Andreas , Ako Ayuk M. , Saalfrank Rolf W. , Heinemann Frank W. , Hampel Frank , Petukhov Konstantin , Gieb Klaus , Stocker Michael , Müller Paul 
Published: March 2010

AbstractReaction of cobalt(II) chloride hexahydrate with N‐substituted diethanolamines H2L2–4 (3) in the presence of LiH in anhydrous THF leads under anaerobic conditions to the formation of three isostructural tetranuclear cobalt(II) complexes [CoII4(Cl)4(HL2–4)4] (4) with a [Co4(μ3‐O)4]4+ cubane core. According to X‐ray structural analyses, the complexes 4 a,c crystallize in the tetragonal space group I41/a, whereas for complex 4 b the tetragonal space group P$\bar 4$ was found. In the solid state the orientation of the cubane cores and the formation of a 3D framework were controlled by the ligand substituents of the cobalt(II) cubanes 4. This also allowed detailed magnetic investigations on single crystals. The analysis of the SQUID magnetic susceptibility data for 4 a gave intramolecular ferromagnetic couplings of the cobalt(II) ions (J1≈20.4 K, J2≈7.6 K), resulting in an S=6 ground‐state multiplet. The anisotropy was found to be of the easy‐axis type (D=−1.55 K) with a resulting anisotropy barrier of Δ≈55.8 K. Two‐dimensional electron‐gas (2DEG) Hall magnetization measurements revealed that complex 4 a is a single‐molecule magnet and shows hysteretic magnetization characteristics with typical temperature and sweep‐rate dependencies below a blocking temperature of about 4.4 K. The hysteresis loops collapse at zero field owing to fast quantum tunneling of the magnetization (QTM). The structural and electronic properties of cobalt(II) cubane 4 a, deposited on a highly oriented pyrolytic graphite (HOPG) surface, were investigated by means of STM and current imaging tunneling spectroscopy (CITS) at RT and standard atmospheric pressure. In CITS measurements the rather large contrast found at the expected locations of the metal centers of the molecules indicated the presence of a strongly localized LUMO.
The Effect of the Equatorial Environment on Oxo‐Group Silylation of the Uranyl Dication: A Computational Study
Authors: Yahia Ahmed , Arnold Polly L. , Love Jason B. , Maron Laurent 
Published: March 2010

AbstractA theoretical investigation of the reductive oxo‐group silylation reaction of the uranyl dication held in a Pacman macrocylic environment has been carried out. The effect of the modeling of the Pacman ligand on the reaction profiles is found to be important, with the dipotassiation of a single oxo group identified as a key component in promoting the reaction between the SiX and uranium–oxo bonds. This reductive silylation reaction is also proposed to occur in an aqueous environment but was found not to operate on bare ions; in this latter case, substitution of a ligand in the equatorial plane was the most likely reaction. These results demonstrate the importance of the presence but not the identity of the equatorial ligands upon the silylation of the uranyl UO bond.
Small area estimation of poverty indicators
Authors: Molina Isabel , Rao J. N. K. 
Published: March 2010

AbstractThe authors propose to estimate nonlinear small area population parameters by using the empirical Bayes (best) method, based on a nested error model. They focus on poverty indicators as particular nonlinear parameters of interest, but the proposed methodology is applicable to general nonlinear parameters. They use a parametric bootstrap method to estimate the mean squared error of the empirical best estimators. They also study small sample properties of these estimators by model‐based and design‐based simulation studies. Results show large reductions in mean squared error relative to direct area‐specific estimators and other estimators obtained by “simulated” censuses. The authors also apply the proposed method to estimate poverty incidences and poverty gaps in Spanish provinces by gender with mean squared errors estimated by the mentioned parametric bootstrap method. For the Spanish data, results show a significant reduction in coefficient of variation of the proposed empirical best estimators over direct estimators for practically all domains. The Canadian Journal of Statistics 38: 369–385; 2010 © 2010 Statistical Society of Canada
The Venlafaxine “Heart Revenge:” A Short Report
Authors: Caroselli Costantino , Ricci Giorgio 
Published: March 2010

AbstractA 40‐year‐old white woman with a history of venlafaxine abuse was admitted to our emergency department within 3 days after attempting suicide. On admission, blood pressure was 140/85 mm Hg with 70 beats per minute. The resting 12‐lead ECG showed a significant ST‐segment elevation in the anterolateral leads consistent with acute anterolateral myocardial infarction (anterolateral AMI). Noninvasive monitoring of blood oxygen saturation showed 97% while she was breathing room air. Laboratory findings showed the increase of troponin I up to 16 µg/L (normal range, 0–0.05 µg/L) and creatine kinase MB subunit levels up to 166 U/L (normal range, 0–25 U/L). An emergency coronary angiogram was normal. Venlafaxine is generally prescribed for the treatment of major depression, as well as, generalized and social anxiety. This is the first time in the literature that we describe an association between myocardial infarction and an overdose with venlafaxine. Copyright © 2010 Wiley Periodicals, Inc.
Human mesenchymal stem cells and their use in cell‐based therapies
Authors: Motaln Helena , Schichor Cristian , Lah Tamara T. 
Published: March 2010

AbstractThe human population is increasingly facing various diseases, including types of cancer, that cannot be cured with conventional drugs. Advanced drug targeting of tumor cells is also often impossible when treating highly invasive and infiltrative tumors such as glioblastoma or pulmonary cancer, because of tumor cells' high migration and invasiveness. Pluripotent human mesenchymal stem cells (hMSCs) have been extensively studied, and strategies are being proposed for treating “incurable” cancers and injury/disease‐affected organs. Because of their own intrinsic properties, involving homing and immunomodulatory potency, hMSCs could be used as an excellent cell/drug delivery vehicle in those cell‐based therapies. Their unprecedented use has been shadowed, however, by their spontaneous transformation, which links them to cancer‐initiating cells during tumor development. How malignant initiation proceeds in vivo, and what are the exact characteristics of the cancer‐initiating cells, still remain to be investigated. In the present review, the authors summed up the most recent knowledge about hMSC characteristics, their malignant transformation, and outlined the possibilities of their safe use in novel cell‐based therapies. Cancer 2010. © 2010 American Cancer Society.