bluuebunny/crossref_metadata_2025_split huggingface dataset:
Memetakan Tantangan Pendidikan Kristiani bagi Remaja Menghadapi Gaya Hidup Era Society 5.0
Authors: Saputro Joko , Missa Antonius , Sitinjak Abraham Pontius 
Published: May 2024

This paper describes the impact of the emergence of Society 5.0, a new civilization in the information age. Today humans are faced with a completely new situation in the arena of history. With the presence of Society 5.0, it is hoped that the community can solve various social challenges and problems by utilizing various innovations born in the Industrial Revolution 4.0. This is a new civilization, a new world, a time in which a human-centered society balances economic progress with the resolution of social problems by a system that integrates cyberspace and physical space. Society 5.0 will balance economic development and solve social problems. Then, is it true that Society 5.0 will bring progress for the benefit of many people? Civilization Society 5.0 is an answer as well as new challenges that have emerged as a result of the era of the Industrial Revolution 4.0, which was accompanied by disruption marked by a world full of turmoil, uncertainty, complexity, and ambiguity, of course, it is a new hope for families to educate their children so as not to experience disruption. This research method is the theological method in Christian religious education. Through this paper, the authors put conceptual ideas for Christian religious education, especially in building a harmonious family, and several solutions to the challenges of the civilization of Society 5.0. AbstrakDengan kehadiran Society 5.0 diharapkan masyarakat dapat menyelesaikan berbagai tantangan dan permasalahan sosial dengan memanfaatkan berbagai inovasi yang lahir di era Revolusi industri 4.0. Inilah sebuah peradaban dunia baru, sebuah masa di mana masyarakat berpusat pada manusia yang menyeimbangkan kemajuan ekonomi dengan penyelesaian masalah sosial oleh sistem yang mengintegrasikan ruang dunia maya dan ruang fisik. Lalu, apakah benar bahwa Society 5.0 akan membawa kemajuan bagi kemaslahatan orang banyak? Tulisan ini bertujuan mengurai dampak yang ditimbulkan akibat dari kemunculan Society 5.0 yang merupakan peradaban baru di era informasi. Metode penelitian ini adalah metode analitis teologis bidang pendidikan agama Kristen. Melalui tulisan ini penulis menaruh gagasan konseptual bagi Pendidikan agama Kristen khususnya dalam membangun keluarga harmonis, serta beberapa solusi dalam menyambut tantangan yang didapat dari peradaban Society 5.0. Hasil penelitian ini adalah Peradaban Society 5.0 merupakan jawaban sekaligus tantangan baru yang muncul akibat era Revolusi Industri 4.0 yang dibarengi disrupsi yang ditandai dunia yang penuh gejolak, ketidakpastian, kompleksitas, dan ambiguitas, tentu saja itu merupakan harapan baru bagi keluarga-keluarga untuk mendidik anak-anaknya agar tidak mengalami disrupsi. Society 5.0 menyeimbangkan pembangunan ekonomi dan menyelesaikan masalah sosial.
Penerapan Kurikulum Learner Centered Design Untuk Meningkatkan Partisipasi Remaja Usia 15-17 Tahun dalam Pelayanan Koinonia
Authors: Tobing Sarah Gracia , Messakh Jefrit Johanis , Toulasik Ferderika 
Published: May 2024

Kurikulum merupakan alat yang didalamnya terdapat seperangkat pembelajaran yang digunakan dalam pelaksanaan pendidikan di suatu lembaga pendidikan sehingga kurikulum sangat penting dalam pelaksanaan pendidikan demi ketercapaian suatu tujuan. Pendidikan tidak hanya dilakukan di sekolah, tetapi, juga dapat dilakukan di gereja. Namun, permasalahan yang sering muncul adalah terdapat gereja belum memiliki kurikulum dalam melaksanakan Pendidikan Agama Kristen dan kesulitan dalam menerapkan kurikulum yang dirancang sehingga aktivitas pembelajaran di gereja tidak berjalan dengan teratur untuk mencapai suatu tujuan. Penelitian ini bertujuan untuk mendeskripsikan kurikulum Learner Centered Design dapat meningkatkan partisipasi remaja dalam pelayanan koinonia. Metode yang digunakan adalah metode penelitian kualitatif dengan pendekatan studi kepustakaan. Hasil penelitian adalah dengan menggunakan desain kurikulum Learner Centered Design dapat meningkatkan partisipasi remaja usia 15-17 dalam pelayanan koinonia.
Queer Gothic Literature and Culture
Authors: Westengard Laura 
Published: May 2024

Here, it is observed that since the first Gothic novel, Horace Walpole’s The Castle of Otranto (1764), the Gothic has included themes of transgressive sexuality. Though Gothic themes and tropes have morphed over the years to reflect shifting cultural anxieties and desires, Gothicism along with its inherent queerness has persisted in various forms up to the present. This chapter highlights examples of queer Gothic in 20th-century cultural production across multiple genres and media, including queer Gothic cinema such as Dracula’s Daughter (1936), Rebecca (1940), and Suddenly Last Summer (1959), fiction such as Shirley Jackson’s The Haunting of Hill House (1959) and Anne Rice’s The Vampire Chronicles (1976–), and late 20th century AIDS-era visual and performance art. Through these examples, the chapter examines queerness within the Gothic, the gothicism in queer culture, and the function of the queer Gothic as an anti-normative orientation.
Sufi Theoeroticism, the Sophianic Feminine and Desdemona’s Tragic Heroism
Authors: Langis Unhae Park 
Published: May 2024

This essay presents an ecumenical Sufi reading of Othello that meshes Sufi and Christian spiritual striving through Neoplatonism. The sapiential lens of Sufi theoeroticism, which links beauty to divine love, reveals how Desdemona both loves Othello as the Stranger in the divine sphere and enacts radical love and hospitality in the socio-political sphere of racist, Islamophobic Europe. Despite Iago’s noxious influence that diverts Othello from their joint aspiration to ‘perfect soul’ (1.2.30), Desdemona continues unfailingly on the Path, ascending to the Sophianic Feminine through her death. Included are new readings of the play’s end. The Willow Song, with its Sufized reference to the Barbary coast, becomes freshly backgrounded in ancient Egyptian mythology and intertextually read with Rumi’s own willow song, or Nay-nameh, in the preface to his famous Masnavi. Accordingly, Desdemona’s final words to Emilia, ‘Commend me to my kind lord. O, farewell’ (5.2.123–5), refer less to her earthly than to her spiritual lord. Despite her reduction to ‘nothing’ legally and sexually, Desdemona’s final act of kenosis, reveals a peerless largesse/largeness of soul, lifting her to saintly tragic heroism.
Enduring the Eventual: A Virtuous Way of Reading Shakespeare
Authors: Moretti Thomas J. 
Published: May 2024

This essay considers the reading of Shakespeare as a potentially virtuous act in the university classroom. It treats Shakespeare’s tragedies as low-stakes material that can reveal the high moral stakes for students who make personal the ethical questions that Shakespeare’s plays raise. Focusing on marital abuse in Othello, myopic scapegoating in Macbeth, and the prudence, courage, and compassion that characters in both plays lack, the essay combines textual analysis and critical self-inquiry into a method of reading for individual empowerment and virtue cultivation. Consequently, it claims that such an approach to reading would prepare students for eventual ethical scenarios that call for intense, and often immediate, action. Whether witnessing domestic violence, finding the good through physiological cues, and participating in a community to support those sick in the spirit, students could use Shakespeare’s plays as scripts to anticipate and eventually to respond virtuously to sudden, exigent ethical situations.
Imagining what you intend
Authors: Langland-Hassan Peter 
Published: May 2024

If we are free to imagine what we choose, this is likely because our intentions determine what we are imagining. However, in a recent article, Munro and Strohminger (2021) argue that, in some cases of imagistic imagining, our intentions do not determine what we are imagining. They offer examples where, intuitively, a person intends to imagine one thing but, due to the causal source of the image used, imagine another. This paper acknowledges the challenge posed by these cases while arguing on several grounds that, when present, intentions nevertheless always suffice to determine the object of one’s imaginings. I conclude by explaining how intentions could fix the objects of episodic rememberings in much the same way as they do for imaginings, thereby bolstering the case that remembering is a kind of imagining.
Relationship between gut microbiota and the pathogenesis of gestational diabetes mellitus: a systematic review
Authors: Ma Sheng , Wang Yuping , Ji Xiaoxia , Dong Sunjuan , Wang Shengnan , Zhang Shuo , Deng Feiying , Chen Jingxian , Lin Benwei , Khan Barkat Ali , Liu Weiting , Hou Kaijian 
Published: May 2024

IntroductionGestational diabetes mellitus (GDM) is a form of gestational diabetes mellitus characterized by insulin resistance and abnormal function of pancreatic beta cells. In recent years, genomic association studies have revealed risk and susceptibility genes associated with genetic susceptibility to GDM. However, genetic predisposition cannot explain the rising global incidence of GDM, which may be related to the increased influence of environmental factors, especially the gut microbiome. Studies have shown that gut microbiota is closely related to the occurrence and development of GDM. This paper reviews the relationship between gut microbiota and the pathological mechanism of GDM, in order to better understand the role of gut microbiota in GDM, and to provide a theoretical basis for clinical application of gut microbiota in the treatment of related diseases.MethodsThe current research results on the interaction between GDM and gut microbiota were collected and analyzed through literature review. Keywords such as "GDM", "gut microbiota" and "insulin resistance" were used for literature search, and the methodology, findings and potential impact on the pathophysiology of GDM were systematically evaluated.ResultsIt was found that the composition and diversity of gut microbiota were significantly associated with the occurrence and development of GDM. Specifically, the abundance of certain gut bacteria is associated with an increased risk of GDM, while other changes in the microbiome may be associated with improved insulin sensitivity. In addition, alterations in the gut microbiota may affect blood glucose control through a variety of mechanisms, including the production of short-chain fatty acids, activation of inflammatory pathways, and metabolism of the B vitamin group.DiscussionThe results of this paper highlight the importance of gut microbiota in the pathogenesis of GDM. The regulation of the gut microbiota may provide new directions for the treatment of GDM, including improving insulin sensitivity and blood sugar control through the use of probiotics and prebiotics. However, more research is needed to confirm the generality and exact mechanisms of these findings and to explore potential clinical applications of the gut microbiota in the management of gestational diabetes. In addition, future studies should consider the interaction between environmental and genetic factors and how together they affect the risk of GDM.
Shaping the future of conservation: a model for restoring oxbows in Iowa and beyond
Authors: Wilke Karen , Rust Andrew , Weissenfluh Darrick , Iddings Brandon , Wulf Shane 
Published: May 2024

Oxbows, once an abundant and natural feature of the landscape, have been nearly eliminated due to the effects of the Anthropocene, consequently impacting water quality, flood storage capacity, and the wildlife that depend on this habitat. These depressional basins within floodplains naturally accumulate sediment over time, but the sedimentation rate of oxbows over the last 100 years has greatly increased. The primary sources of sediment are from human activity, including erosion from agricultural fields and urban developments, drainage alterations, precipitation changes associated with climate change, and disconnection from their rivers and natural river hydraulics. Outlined in this manuscript is a step-by-step guide for restoring oxbows, based on 20 years of experience and lessons learned implementing oxbow restorations in Iowa on first-, second-, and third-order streams. Our goal is to provide conservation services providers and others interested in restoring degraded oxbows with the tools and expertise to confidently restore oxbows to achieve conservation goals.
Rheumatoid arthritis increases the risk of heart failure: results from the cross-sectional study in the US population and mendelian randomization analysis in the European population
Authors: Kadier Kaisaierjiang , Dilixiati Diliyaer , Zhang Xu , Li Huan , Kuang Lirong , Huang Jian , Cai Xintian , Ling Tao , Kong Fanqi , Liu Xiaozhu 
Published: May 2024

ObjectiveRheumatoid arthritis (RA) is a chronic systemic autoimmune disease. Among its various complications, heart failure (HF) has been recognized as the second leading cause of cardiovascular death in RA patients. The objective of this study was to investigate the relationship between RA and HF using epidemiological and genetic approachesMethodsThe study included 37,736 participants from the 1999-2020 National Health and Nutrition Examination Survey. Associations between RA and HF in the US population were assessed with weighted multivariate logistic regression analysis. A two-sample Mendelian randomization (MR) analysis was employed to establish the causal relationship between the two variables. The primary analysis method utilized was inverse variance weighting (IVW). Additionally, horizontal pleiotropy and heterogeneity were assessed to account for potential confounding factors. In cases where multiple independent datasets were accessible during MR analysis, we combined the findings through a meta-analytical approach.ResultsIn observational studies, the prevalence of HF in combination with RA reached 7.11% (95%CI 5.83 to 8.39). RA was positively associated with an increased prevalence of HF in the US population [odds ratio (OR):1.93, 95% confidence interval (CI):1.47-2.54, P &lt; 0.0001]. In a MR analysis utilizing a meta-analytical approach to amalgamate the results of the IVW method, we identified a significant causal link between genetically predicted RA and a heightened risk of HF (OR = 1.083, 95% CI: 1.028-1.141; P = 0.003). However, this association was not deemed significant for seronegative RA (SRA) (OR = 1.028, 95% CI: 0.992-1.065; P = 0.126). These findings were consistent across sensitivity analyses and did not indicate any horizontal pleiotropy.ConclusionRA correlates with an elevated prevalence of HF within the US population. Furthermore, genetic evidence derived from European populations underscores a causal link between RA and the risk of HF. However this association was not significant in SRA.
High expression of BTN3A1 is associated with clinical and immunological characteristics and predicts a poor prognosis in advanced human gliomas
Authors: Kone Abdou-samad , Ghouzlani Amina , Qandouci Ahmed , Issam Salah Nour el Imane , Bakoukou Yann , Lakhdar Abdelhakim , Karkouri Mehdi , Badou Abdallah 
Published: May 2024

IntroductionGliomas represent the most prevalent and aggressive tumors within the central nervous system. Despite the current standard treatments, the median survival time for glioblastoma patients remains dismal, hovering around 14 months. While attempts have been made to inhibit the PD-1/PD-L1 and CTLA-4/CD80-CD86 axes through immunotherapy, the outcomes have yet to demonstrate significant efficacy. The immune checkpoint Butyrophilin 3A1 (BTN3A1) can either be involved in advantageous or detrimental function depending on the cancer type.MethodsIn our study, we utilized a Moroccan cohort to delve into the role of BTN3A1 in gliomas. A transcriptomic analysis was conducted on 34 patients, which was then corroborated through a protein analysis in 27 patients and validated using the TCGA database (n = 667).ResultsOur results revealed an elevated expression of BTN3A1 in glioblastoma (grade 4), as evidenced in both the TCGA database and our cohort of Moroccan glioma patients. Within the TCGA cohort, BTN3A1 expression was notably higher in patients with wild-type IDH. We observed a positive correlation between BTN3A1 expression and immune infiltration of B cells, CD8+ T cells, naive CD4+ T cells, and M2 macrophages. Patients exhibiting increased BTN3A1 expression also presented elevated levels of TGF‐β, IL‐10, and TIM‐3 compared to those with reduced BTN3A1 expression. Notably, patients with high BTN3A1 expression were associated with a poorer prognosis than their counterparts with lower expression.ConclussionOur findings suggest that BTN3A1 might promote the establishment of an immunosuppressive microenvironment. Consequently, targeting BTN3A1 could offer novel therapeutic avenues for the management of advanced gliomas.
The investigation of the role of oral-originated Prevotella-induced inflammation in childhood asthma
Authors: Yan Tongtong , Bao Yuling , Cao Shuyuan , Jiang Ping , Zhang Zhan , Li Lei , Kang Yulin , Wu Qian 
Published: May 2024

Background and objectivesThe oral and gut microbiota play significant roles in childhood asthma pathogenesis. However, the communication dynamics and pathogenic mechanisms by which oral microbiota influence gut microbiota and disease development remain incompletely understood. This study investigated potential mechanisms by which oral-originated gut microbiota, specifically Prevotella genus, may contribute to childhood asthma etiology.MethodsOral swab and fecal samples from 30 asthmatic children and 30 healthy controls were collected. Microbiome composition was characterized using 16S rRNA gene sequencing and metagenomics. Genetic distances identified potential oral-originated bacteria in asthmatic children. Functional validation assessed pro-inflammatory properties of in silico predicted microbial mimicry peptides from enriched asthma-associated species. Fecal metabolome profiling combined with metagenomic correlations explored links between gut microbiota and metabolism. HBE cells treated with Prevotella bivia culture supernatant were analyzed for lipid pathway impacts using UPLC-MS/MS.ResultsChildren with asthma exhibited distinct oral and gut microbiota structures. Prevotella bivia, P. disiens, P. oris and Bacteroides fragilis were enriched orally and intestinally in asthmatics, while Streptococcus thermophilus decreased. P. bivia, P. disiens and P. oris in asthmatic gut likely originated orally. Microbial peptides induced inflammatory cytokines from immune cells. Aberrant lipid pathways characterized asthmatic children. P. bivia increased pro-inflammatory and decreased anti-inflammatory lipid metabolites in HBE cells.ConclusionThis study provides evidence of Prevotella transfer from oral to gut microbiota in childhood asthma. Prevotella’s microbial mimicry peptides and effects on lipid metabolism contribute to disease pathogenesis by eliciting immune responses. Findings offer mechanistic insights into oral-gut connections in childhood asthma etiology.
A preliminary study on the application of electrical impedance tomography based on cerebral perfusion monitoring to intracranial pressure changes
Authors: Yan Xiaoheng , Wang Yu , Li Weichen , Zhu Mingxu , Wang Weice , Xu Canhua , Li Kun , Liu Benyuan , Shi Xuetao 
Published: May 2024

BackgroundIn intracranial pathologic conditions of intracranial pressure (ICP) disturbance or hemodynamic instability, maintaining appropriate ICP may reduce the risk of ischemic brain injury. The change of ICP is often accompanied by the change of intracranial blood status. As a non-invasive functional imaging technique, the sensitivity of electrical impedance tomography (EIT) to cerebral hemodynamic changes has been preliminarily confirmed. However, no team has conducted a feasibility study on the dynamic detection of ICP by EIT technology from the perspective of non-invasive whole-brain blood perfusion monitoring. In this study, human brain EIT image sequence was obtained by in vivo measurement, from which a variety of indicators that can reflect the tidal changes of the whole brain impedance were extracted, in order to establish a new method for non-invasive monitoring of ICP changes from the level of cerebral blood perfusion monitoring.MethodsValsalva maneuver (VM) was used to temporarily change the cerebral blood perfusion status of volunteers. The electrical impedance information of the brain during this process was continuously monitored by EIT device and real-time imaging was performed, and the hemodynamic indexes of bilateral middle cerebral arteries were monitored by transcranial Doppler (TCD). The changes in monitoring information obtained by the two techniques were compared and observed.ResultsThe EIT imaging results indicated that the image sequence showed obvious tidal changes with the heart beating. Perfusion indicators of vascular pulsation obtained from EIT images decreased significantly during the stabilization phase of the intervention (PAC: 242.94 ± 100.83, p &lt; 0.01); perfusion index which reflects vascular resistance increased significantly in the stable stage of intervention (PDT: 79.72 ± 18.23, p &lt; 0.001). After the intervention, the parameters gradually returned to the baseline level before compression. The changes of EIT indexes in the whole process are consistent with the changes of middle cerebral artery velocity related indexes shown in TCD results.ConclusionThe EIT image combined with the blood perfusion index proposed in this paper can reflect the decrease of cerebral blood flow under the condition of increased ICP in real time and intuitively. With the advantages of high time resolution and high sensitivity, EIT provides a new idea for non-invasive bedside measurement of ICP.
The relationship between caffeine consumption and colon cancer prevalence in a nationally representative population
Authors: Qu Yuhua , Cheng Yulu , Chen Fengming 
Published: May 2024

AimsThis study examines the correlation between caffeine consumption and the prevalence of colon cancer.MethodsUtilizing data from the National Health and Nutrition Examination Survey (NHANES) for the years 2001 to 2014, we applied weighted logistic regression to evaluate the association between caffeine consumption and the prevalence of colon cancer. This analysis accounted for variables including age, gender, race, education, poverty income ratio, smoking status, alcohol consumption, and diabetes. The findings were expressed as weighted odds ratios (ORs) with accompanying 95% confidence intervals (CIs). The restricted cubic spline analysis was performed to exam the dose-dependent relationship.ResultsThe study included 27,637 participants, of which 144 were diagnosed with colon cancer and 27,493 served as controls. Individuals in the highest quartile (Q4) of caffeine consumption (Q4) displayed a significantly increased risk of colon cancer compared to those in the lowest quartile (Q1), with a weighted OR of 2.00 (95% CI: 1.11–3.59; p = 0.022). Additionally, restricted cubic spline analysis indicated a significant correlation between higher caffeine intake and increased colon cancer risk, with an overall association p-value of 0.007.ConclusionThese findings suggest a potential relationship between higher levels of caffeine consumption and an increased risk of colon cancer. The dose–response relationship suggests a notable correlation at higher caffeine intake levels. Further investigations are warranted to confirm these results and elucidate potential underlying mechanisms.