bluuebunny/crossref_metadata_2025_split huggingface dataset:
A importância do calendário vacinal e o impacto das fake news na adesão
Authors: Santos Natasha Freires dos 
Published: June 2024

O artigo aborda a história vacinal no Brasil desde a criação do Programa Nacional de Imunização até os desafios enfrentados atualmente relacionados à disseminação de notícias falsas. Objetivo: Analisar os prejuízos causados à saúde pública com a divulgação e o compartilhamento de informações inverídicas nos meios de comunicação e como isso pode trazer à tona novos surtos de doenças já erradicadas. Metodologia: Este artigo consiste em uma revisão integrativa e análise de artigos. Para compor o estudo foram selecionadas produções científicas que tratassem da temática em questão, com o mesmo viés, para tanto foi necessária uma busca por artigos publicados no período de cinco anos, em português e como o uso dos descritores de saúde: vacinação, programas de imunização, saúde pública e desinformação. Resultados: Foram encontrados 61 artigos publicados, os artigos foram lidos e analisados, restando 11 que se enquadram na temática da pesquisa. Considerações finais: Diante dos fatos apresentados fica claro que a fake news e as teorias conspiratórias compartilhadas nas redes sociais são apontadas como um grande desafio a ser enfrentado na sociedade tecnológica, uma vez que tem um grande potencial de influenciar negativamente a favor da não vacinação.
UJI EFEK ANTIDIABETES SEDUHAN KOMBINASI JAHE (Zingiber officinale), SEREH (Cymbopogon citratus), DAN KAYU MANIS (Cinnamomum verum) PADA MENCIT JANTAN (Mus musculus)
Authors: Ni Putu Natasya Dewanti  , Ajeng Dian Pertiwi  , En Purmafitriah  , Evi Fatmi Utami  
Published: June 2024

Diabetes melitus (DM) atau penyakit kencing manis merupakan penyakit yang disebabkan oleh kelainan yang berhubungan dengan hormon insulin. Jahe, sereh dan kayu manis adalah tanaman tradisional yang berpotensi untuk dikembangkan sebagai obat herbal. Seduhan kombinasi dari tanaman tradisional ini dapat dimanfaatkan sebagai alternatif pengobatan diabetes melitus. Seduhan jahe, sereh dan kayu manis mengandung metabolit sekunder yaitu flavonoid, terpenoid dan tanin, Ketiga senyawa aktif tersebut memiliki aktivitas sebagai antioksidan, antidiabetes, dan antiinflamasi. Penelitian ini bertujuan untuk menzgetahui efek antidiabetes seduhan kombinasi JSKM (jahe (Zingiber officinale), sereh (Cymbopogon citratus) dan kayu manis (Cinnamomum verum)) pada mencit jantan (Mus Musculus). Desain dari penelitian ini adalah eksperimental dengan metode analisis datanya menggunakan SPSS 16.0. Pengamatan Waktu penyembuhan dilakukan dengan cara mengamati penurunan kadar gula darah selama 7 hari. Dalam penelitian ini digunakan 5 kelompok perlakuan yaitu kelompok kontrol negatif (aquadest), kontrol positif (glibenklamid), dosis P1 (162mg/kgBB), dosis P2 (324mg/kgBB), dan dosis P3 (486mg/kgBB). Dosis yang paling efektif dari uji efek antidiabetes seduhan kombinasi JSKM pada mencit jantan yaitu pada kelompok P3 dengan dosis 486 mg mg/kgBB.
The City Dyrrhachium (Durres) from Its Foundation to the 10 century
Authors: Qerimi Muhamet 
Published: June 2024

The purpose of the research paper is to examines the historical significance of Dyrrhachium (modern-day Durrës), as a pivotal economic, commercial, and political center in the Adriatic region from antiquity to the medieval period.
The scientific novelty resides in its meticulous exploration of Dyrrhachium’s economic, commercial, and political significance in during Antiquity and the early Middle Ages. The research elucidates the city’s remarkable ability to navigate and thrive amidst various external challenges, offering invaluable insights into the dynamics of the Adriatic region during both ancient and medieval periods. This study contributes to a nuanced understanding of regional interactions and socio-economic dynamics, shedding light on the intricate interplay of factors that shaped Dyrrhachium’s enduring prominence.
Conclusion. Dating back to its establishment by Hellenic settlers around 625 BCE, Dyrrhachium witnessed a remarkable trajectory of development under various rulers, including the Romans and Byzantines, despite enduring significant external threats such as Ostrogoth and Slavic invasions. Notably, the construction of the Egnatia road served as a catalyst, amplifying Dyrrhachium’s economic importance by facilitating trade between the Eastern and Western regions. Through tumultuous times, Dyrrhachium showcased remarkable economic resilience, ultimately emerging as the preeminent city in the Byzantine Empire’s Balkan region.
The despite facing numerous political upheavals and external invasions over the centuries, Dyrrhachium emerged as an exemplar of resilience, establishing itself as a stalwart economic and political nucleus in the Adriatic region. Its strategic location, complemented by robust commercial activities and administrative autonomy, fortified Dyrrhachium’s position as a formidable player in regional affairs, ensuring its enduring prominence across antiquity and the medieval era.
The predictors to self-reported and performance-based physical function in knee osteoarthritis patients: a cross-sectional study
Authors: Wang Qian-wen , Man Gene Chi-wai , Choi Ben Chi-yin , Yeung Yi-man , Qiu Ji-hong , Lu Xiao-min , Ong Michael Tim-yun , Yung Patrick Shu-hang 
Published: June 2024

BackgroundOsteoarthritis (OA) knee patients have limited ability in physical function, or difficulties with physical tasks and activities may develop disability. This study aimed to observe the predictors of self-reported and performance-based physical function in patients with knee OA by analyzing the impacts of demographic, pathological, and muscle impairment factors.Methods135 knee OA patients participated in this study to complete self-reported questionnaires using Knee Injury and Osteoarthritis Outcome Score (KOOS). When measuring performance-based physical function, a 6-meter gait speed (6MGS) test was measured to evaluate their mobility, and a 5-time Sit-to-Stand test (5STS) was assessed to evaluate their balance. Pain intensity, knee extensor and flexor muscle strength, age, body mass index (BMI), durations of symptoms, and radiographic severity were also collected. Spearman correlation and stepwise multiple linear regression were used to explore the association and predictors in self-reported and performance-based physical function.ResultsBMI and durations of symptoms did not indicate any significant correlation with either self-reported or performance-based physical function. Age is significantly negatively associated with 6MGS (r2 = −0.383, p &lt; 0.01), while knee extensor muscle strength has a moderate correlation with 5STS (r2 = −0.528, p &lt; 0.01). In the stepwise multiple linear regression models, pain intensity (β = 0.712, p &lt; 0.001), knee flexor muscle strength (β = 0.112, p = 0.042) were significantly associated with self-reported physical function in daily activities and contributed to 55.0% of the variance in KOOS-PF score. Knee muscle strength, including knee extensor (5STS: β = −0.428, p &lt; 0.001) and flexor muscle strength (6MGS: β = 0.367, p &lt; 0.001), were the main predictors with performance-based physical function.ConclusionPain intensity was the leading risk factor of self-reported physical function, and knee flexor muscle strength contributed as well. The severity of knee OA, durations of symptoms and BMI did not contribute to physical function. However, knee extensor and flexor muscle strength were the main predictors of performance-based performance. Our results show that strengthening of weak knee muscles in both quadriceps and hamstring muscle strength should be considered a priory consideration in knee OA no matter if people are in the early or end-stage of knee OA.
Lithium-coupled electron transfer reactions of nano-confined WOx within Zr-based metal–organic framework
Authors: Ghuffar Hafsa Abdul , Noh Hyunho 
Published: June 2024

Interfacial charge transfer reactions involving cations and electrons are fundamental to (photo/electro) catalysis, energy storage, and beyond. Lithium-coupled electron transfer (LCET) at the electrode-electrolyte interfaces of lithium-ion batteries (LIBs) is a preeminent example to highlight the importance of charge transfer in modern-day society. The thermodynamics of LCET reactions define the minimal energy for charge/discharge of LIBs, and yet, these parameters are rarely available in the literature. Here, we demonstrate the successful incorporation of tungsten oxides (WOx) within a chemically stable Zr-based metal−organic framework (MOF), MOF-808. Cyclic voltammograms (CVs) of the composite, WOx@MOF-808, in Li+-containing acetonitrile (MeCN)-based electrolytes showed an irreversible, cathodic Faradaic feature that shifted in a Nernstian fashion with respect to the Li+ concentration, i.e., ∼59 mV/log [(Li+)]. The Nernstian dependence established 1:1 stoichiometry of Li+ and e−. Using the standard redox potential of Li+/0, the apparent free energy of lithiation of WOx@MOF-808 (ΔGapp,Li) was calculated to be −36 ± 1 kcal mol−1. ΔGapp,Li is an intrinsic parameter of WOx@MOF-808, and thus by deriving the similar reaction free energies of other metal oxides, their direct comparisons can be achieved. Implications of the reported measurements will be further contrasted to proton-coupled electron transfer (PCET) reactions on metal oxides.
Emotional modulation of statistical learning in visual search
Authors: Zinchenko Artyom , Bierlich Afton M. , Conci Markus , Müller Hermann J. , Geyer Thomas 
Published: June 2024

IntroductionVisual search is facilitated when participants encounter targets in repeated display arrangements. This “contextual-cueing” effect is attributed to incidental learning of spatial distractor-target relations, which subsequently guides visual search more effectively toward the target location. Conversely, behaviorally significant, though task-irrelevant, negative emotional stimuli may involuntarily capture attention and thus hamper performance in visual search. This raises the question of how these two attention-guiding factors connect.MethodsTo this end, we investigated how an emotionally alerting stimulus induced by different classes of emotional (face, scene) pictures prior to the search task relates to memory-related plasticity. We tested 46 participants who were presented with repeated and non-repeated search layouts, preceded at variable (50, 500, 1,000 ms) intervals by emotional vs. neutral faces or scenes.ResultsWe found that contextual learning was increased with emotional compared to neutral scenes, which resulted in no contextual cueing was observed at all, while no modulation of the cueing effect was observed for emotional (vs. neutral) faces. This modulation occurred independent of the intervals between the emotional stimulus and the search display.DiscussionWe conclude that emotional scenes are particularly effective in withdrawing attentional resources, biasing individual participants to perform a visual search task in a passive, i.e., receptive, manner, which, in turn, improves automatic contextual learning.
Open- vs. closed-chest pig models of donation after circulatory death
Authors: Hubacher Valentin , Egle Manuel , Graf Selianne , Arnold Maria , Segiser Adrian , Sanz Maria Nieves , Casoni Daniela , Garcia Casalta Luisana , Nettelbeck Kay , Mihalj Maks , Siepe Matthias , Kadner Alexander , Longnus Sarah 
Published: June 2024

BackgroundDuring donation after circulatory death (DCD), cardiac grafts are exposed to potentially damaging conditions that can impact their quality and post-transplantation outcomes. In a clinical DCD setting, patients have closed chests in most cases, while many experimental models have used open-chest conditions. We therefore aimed to investigate and characterize differences in open- vs. closed-chest porcine models.MethodsWithdrawal of life-sustaining therapy (WLST) was simulated in anesthetized juvenile male pigs by stopping mechanical ventilation following the administration of a neuromuscular block. Functional warm ischemic time (fWIT) was defined to start when systolic arterial pressure was &lt;50 mmHg. Hemodynamic changes and blood chemistry were analyzed. Two experimental groups were compared: (i) an open-chest group with sternotomy prior to WLST and (ii) a closed-chest group with sternotomy after fWIT.ResultsHemodynamic changes during the progression from WLST to fWIT were initiated by a rapid decline in blood oxygen saturation and a subsequent cardiovascular hyperdynamic (HD) period characterized by temporary elevations in heart rates and arterial pressures in both groups. Subsequently, heart rate and systolic arterial pressure decreased until fWIT was reached. Pigs in the open-chest group displayed a more rapid transition to the HD phase after WLST, with peak heart rate and peak rate-pressure product occurring significantly earlier. Furthermore, the HD phase duration tended to be shorter and less intense (lower peak rate-pressure product) in the open-chest group than in the closed-chest group.DiscussionProgression from WLST to fWIT was more rapid, and the hemodynamic changes tended to be less pronounced in the open-chest group than in the closed-chest group. Our findings support clear differences between open- and closed-chest models of DCD. Therefore, recommendations for clinical DCD protocols based on findings in open-chest models must be interpreted with care.
Multi-omics analysis and experimental validation of the value of monocyte-associated features in prostate cancer prognosis and immunotherapy
Authors: Wang YaXuan , Li Chao , He JiaXing , Zhao QingYun , Zhou Yu , Sun HaoDong , Zhu HaiXia , Ding BeiChen , Ren MingHua 
Published: June 2024

BackgroundMonocytes play a critical role in tumor initiation and progression, with their impact on prostate adenocarcinoma (PRAD) not yet fully understood. This study aimed to identify key monocyte-related genes and elucidate their mechanisms in PRAD.MethodUtilizing the TCGA-PRAD dataset, immune cell infiltration levels were assessed using CIBERSORT, and their correlation with patient prognosis was analyzed. The WGCNA method pinpointed 14 crucial monocyte-related genes. A diagnostic model focused on monocytes was developed using a combination of machine learning algorithms, while a prognostic model was created using the LASSO algorithm, both of which were validated. Random forest and gradient boosting machine singled out CCNA2 as the most significant gene related to prognosis in monocytes, with its function further investigated through gene enrichment analysis. Mendelian randomization analysis of the association of HLA-DR high-expressing monocytes with PRAD. Molecular docking was employed to assess the binding affinity of CCNA2 with targeted drugs for PRAD, and experimental validation confirmed the expression and prognostic value of CCNA2 in PRAD.ResultBased on the identification of 14 monocyte-related genes by WGCNA, we developed a diagnostic model for PRAD using a combination of multiple machine learning algorithms. Additionally, we constructed a prognostic model using the LASSO algorithm, both of which demonstrated excellent predictive capabilities. Analysis with random forest and gradient boosting machine algorithms further supported the potential prognostic value of CCNA2 in PRAD. Gene enrichment analysis revealed the association of CCNA2 with the regulation of cell cycle and cellular senescence in PRAD. Mendelian randomization analysis confirmed that monocytes expressing high levels of HLA-DR may promote PRAD. Molecular docking results suggested a strong affinity of CCNA2 for drugs targeting PRAD. Furthermore, immunohistochemistry experiments validated the upregulation of CCNA2 expression in PRAD and its correlation with patient prognosis.ConclusionOur findings offer new insights into monocyte heterogeneity and its role in PRAD. Furthermore, CCNA2 holds potential as a novel targeted drug for PRAD.
Acupuncture for the treatment of diabetic peripheral neuropathy in the elderly: a systematic review and meta-analysis
Authors: Zhang Xinyu , Xiao Lingyong , Qin Yuan , Yang Huan , Wei Xiangcheng , Li Lanping , Zhao Shiqing , Dai Xiaoyu 
Published: June 2024

BackgroundDiabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes mellitus, often causing pain or numbness in the patient’s limbs and even leading to amputation and death. Elderly patients with DPN usually have higher morbidity and more severe results. Acupuncture has been widely used as an effective treatment for DPN in China. However, the efficacy of acupuncture in the treatment of DPN remains unclear. In this review, we aimed to explore the impact of acupuncture in alleviating symptoms of DPN.Method and analysisSix databases were searched from inception to October 2023. We searched Medline, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL), and three Chinese databases, namely China National Knowledge Infrastructure (CNKI), SinoMed, and Wanfang. All randomized controlled trials related to the effect of acupuncture on DPN will be included. There was no restriction in language or publication year. The primary outcome is the response rate. The secondary outcomes are the Toronto clinical scoring system (TCSS), nerve conduction velocities (NCVs), and blood glucose before and after the treatment. Two researchers will be responsible for the selection of study, data extraction, and assessment of study quality independently. RevMan V5.1.0 software will be used to assess the risk of bias and generate data.ResultsWe searched 4518 studies, among which 9 RCTs were considered eligible. Overall, acupuncture treatment had a higher response rate than controls (relative risk (RR), −2.87 [95% confidence interval (CI), −5.27 to −0.48], p = 0.02) and significantly alleviated the symptoms of DPN patients, reduced their blood glucose levels, and improved their NCVs compared to the control group. This study will provide a high-quality synthesis of current available evidence for the clinical treatment of DPN with this therapy.ConclusionThe results suggested that acupuncture might be effective in improving symptoms of DPN in elderly patients. Owing to the overall low quality of the literature included, we need more large-sample, high-quality, and low-bias studies to prove it.
Imaging of colorectal adenomas with pseudoinvasion and malignant polyps using two-photon excitation microscopy
Authors: Florea Maria-Alexandra , Eftimie Lucian George , Glogojeanu Remus Relu , Hristu Radu , Stanciu George A. , Costache Mariana 
Published: June 2024

IntroductionAlthough the incidence and mortality rates of colorectal cancer exhibit significant variability, it remains one of the most prevalent cancers worldwide. Endeavors to prevent colorectal cancer development focus on detecting precursor lesions during colonoscopy. The diagnosis of endoscopically resected polyps relies on hematoxylin and eosin staining examination. For challenging cases like adenomatous polyps with epithelial misplacement, additional diagnostic methods could prove beneficial.MethodsThis paper aims to underscore stromal changes observed in malignant polyps and polyps with pseudoinvasion, leveraging two-photon excitation microscopy (TPEM), a technique extensively employed in the medical field in recent years. Results and discussionsBoth the subjective and quantitative analysis of TPEM images revealed distinct distributions and densities of collagen at the invasion front in malignant polyps compared to areas of pseudoinvasion. TPEM holds potential in discerning true invasion in malignant polyps from pseudoinvasion, offering enhanced visualization of local stromal changes.
miR-617 interacts with the promoter of DDX27 and positively regulates its expression: implications for cancer therapeutics
Authors: Sarkar Neelanjana , Mishra Radha , Gopal Champaka , Kumar Arun 
Published: June 2024

BackgroundPervasive transcription of the eukaryotic genome generates noncoding RNAs (ncRNAs), which regulate messenger RNA (mRNA) stability and translation. MicroRNAs (miRNAs/miRs) represent a group of well-studied ncRNAs that maintain cellular homeostasis. Thus, any aberration in miRNA expression can cause diseases, including carcinogenesis. According to microRNA microarray analyses, intronic miR-617 is significantly downregulated in oral squamous cell carcinoma (OSCC) tissues compared to normal oral tissues.MethodsThe miR-617-mediated regulation of DDX27 is established by performing experiments on OSCC cell lines, patient samples, and xenograft nude mice model. Overexpression plasmid constructs, bisulphite sequencing PCR, bioinformatics analyses, RT-qPCR, Western blotting, dual-luciferase reporter assay, and cell-based assays are utilized to delineate the role of miR-617 in OSCC.ResultsThe present study shows that miR-617 has an anti-proliferative role in OSCC cells and is partly downregulated in OSCC cells due to the hypermethylation of its independent promoter. Further, we demonstrate that miR-617 upregulates DDX27 gene by interacting with its promoter in a dose-dependent and sequence-specific manner, and this interaction is found to be biologically relevant in OSCC patient samples. Subsequently, we show that miR-617 regulates cell proliferation, apoptosis, and anchorage-independent growth of OSCC cells by modulating DDX27 levels. Besides, our study shows that miR-617 exerts its effects through the PI3K/AKT/MTOR pathway via regulating DDX27 levels. Furthermore, the OSCC xenograft study in nude mice shows the anti-tumorigenic potential of miR-617.ConclusionmiR-617-mediated upregulation of DDX27 is a novel mechanism in OSCC and underscores the therapeutic potential of synthetic miR-617 mimics in cancer therapeutics. To the best of our knowledge, miR-617 is the 15th example of a miRNA that upregulates the expression of a protein-coding gene by interacting with its promoter.
Continuance intention and digital health resources from the perspective of elaboration likelihood model and DART model: a structural equation modeling analysis
Authors: Fei Chengcheng , Zhou Haixia , Wu Wei , Jiang Longyuan , Xu Yuanqi , Yu Haiyan 
Published: June 2024

BackgroundInternet hospitals, online health communities, and other digital health APPs have brought many changes to people’s lives. However, digital health resources are experiencing low continuance intention due to many factors, including information security, service quality, and personal characteristics of users.MethodsWe used cross-sectional surveys and structural equation modeling analysis to explore factors influencing user willingness to continue using digital health resources.ResultsInformation quality (β = 0.31, p &lt; 0.05), service quality (β = 0.19, p &lt; 0.05), platform reputation (β = 0.34, p &lt; 0.05), and emotional support (β = 0.23, p &lt; 0.05) have significant positive effects on user value co-creation behavior. Additionally, user trust and perceived usefulness could mediate the association between user value co-creation behavior and continuance intention, with mediation effects of 0.143 and 0.125, respectively. User involvement can positively moderate the association between user value co-creation behavior and user trust (β = 0.151, t = 2.480, p &lt; 0.001). Also, user involvement can positively moderate the association between value co-creation behavior and perceived usefulness (β = 0.103, t = 3.377, p &lt; 0.001).ConclusionThe keys to solving the problem of low continuance intention are improving the quality and service level of digital health resources, and promoting users’ value co-creation behavior. Meanwhile, enterprises should build a good reputation, create a positive communication atmosphere in the community, and enhance user participation and sense of belonging.