bluuebunny/crossref_metadata_2025_split huggingface dataset:
The microtubule-destabilizing agent AUS_001 as a candidate for glioblastoma therapy.
Authors: Koutsioumpa Marina , Carlson Aaron L. , DesRochers Tessa , Chan Peter Y.W. , Risinger April L. , Adams Robert , Bardy Cedric , Thomas Daniel , Lelie Herman 
Published: June 2024

3114 Background: The development of novel drugs targeting glioblastoma (GBM) is crucial due to the aggressive nature of this brain cancer, which often resists current treatments. Microtubules are a well-established target for cancer treatment, however there is a need to identify microtubule targeting agents (MTAs) with decreased toxicity and the ability to also retain efficacy in drug-resistant tumors. The novel MTA, AUS_001 has been shown to impede the growth of 15 established glioma cell lines with a half-maximal inhibitory concentration in the range of 0.04-0.246uM. The goal of the current study was to explore its potential in GBM treatment. Methods: Co-cultures of primary Human brain endothelial cells, pericytes and astrocytes layered in an insert were applied for the assessment of Blood Brain Barrier (BBB) permeability. AUS_001 efficacy against GBM was studied in vitro and in an ex vivo platform of advanced 3D cell culture systems. Differences in drug response were investigated between a Temozolomide (TMZ)-resistant human GBM cell line and parental cells. The ability of AUS_001 to overcome taxane-associated drug resistance was explored in P-glycoprotein (P-gp) and βIII-tubulin over-expression models of drug resistance. A microelectrode array system was used to assess the electrical activity and functionality of human Pluripotent Stem Cell (hPSC)-derived midbrain and cortical neurons, upon dose escalation drug treatments followed by a full media change to allow the recovery period. Results: By employing a 3D Human BBB Model, we demonstrated that AUS_001 is a good BBB permeability substrate. AUS_001 prevents the growth of Parental Primary Patient-Derived GBM and Patient-Derived Glioma Lines enriched in Cancer Stem cells under 2D culturing conditions with high potency. To this end, we evaluated the effect of AUS_001 in 3D spheroids originating from primary GBM patient-derived tumors that include all cells present in each patient’s primary tumor. AUS_001 efficiently prevented the growth of these tumors, including cases where the standard of care, TMZ was not effective. Notably, 2D GBM cultures with acquired TMZ resistance retained sensitivity to the cytotoxic effects of AUS_001. We also found that AUS_001 is less prone to mechanisms of resistance to currently approved MTAs, including increased expression of the βIII-isotype of tubulin or the P-gp drug efflux pump. An in vitro neurotoxicity model revealed that functional damage caused by AUS_001 was reversible, while paclitaxel-treated neurons suffered sustained neurotoxicity. Conclusions: Collectively, we show that AUS_001 has the potential to circumvent significant limitations of clinically approved MTAs, including brain penetration, drug resistance and peripheral neuropathy, making it a promising approach for the treatment of GBM.
Using Bibliometric Data to Define and Understand Publishing Network Equity in Anesthesiology
Authors: Duggan Elizabeth W. , Atwood Gary S. , Sanford Joseph A. , Tsai Mitchell H. , Egbaria Jamal K. , Carmichael-Tanaka Nina , Outland Neal B. 
Published: June 2024

BACKGROUND:
Anesthesiology departments and professional organizations increasingly recognize the need to embrace diverse membership to effectively care for patients, to educate our trainees, and to contribute to innovative research.
1
Bibliometric analysis uses citation data to determine the patterns of interrelatedness within a scientific community. Social network analysis examines these patterns to elucidate the network’s functional properties. Using these methodologies, an analysis of contemporary scholarly work was undertaken to outline network structure and function, with particular focus on the equity of node and graph-level connectivity patterns.

METHODS:
Using the Web of Science, this study examines bibliographic data from 6 anesthesiology-specific journals between January 1, 2017, and August 26, 2022. The final data represent 4453 articles, 19,916 independent authors, and 4436 institutions. Analysis of coauthorship was performed using R libraries software. Collaboration patterns were assessed at the node and graph level to analyze patterns of coauthorship. Influential authors and institutions were identified using centrality metrics; author influence was also cataloged by the number of publications and highly cited papers. Independent assessors reviewed influential author photographs to classify race and gender. The Gini coefficient was applied to examine dispersion of influence across nodes. Pearson correlations were used to investigate the relationship between centrality metrics, number of publications, and National Institutes of Health (NIH) funding.

RESULTS:
The modularity of the author network is significantly higher than would be predicted by chance (0.886 vs random network mean 0.340, P < .01), signifying strong community formation. The Gini coefficient indicates inequity across both author and institution centrality metrics, representing moderate to high disparity in node influence. Identifying the top 30 authors by centrality metrics, number of published and highly cited papers, 79.0% were categorized as male; 68.1% of authors were classified as White (non-Latino) and 24.6% Asian.

CONCLUSIONS:
The highly modular network structure indicates dense author communities. Extracommunity cooperation is limited, previously demonstrated to negatively impact novel scientific work.
2,3
Inequitable node influence is seen at both author and institution level, notably an imbalance of information transfer and disparity in connectivity patterns. There is an association between network influence, article publication (authors), and NIH funding (institutions). Female and minority authors are inequitably represented among the most influential authors. This baseline bibliometric analysis provides an opportunity to direct future network connections to more inclusively share information and integrate diverse perspectives, properties associated with increased academic productivity.
3,4
Association of renal function with mortality among hospitalized patients treated with remdesivir for COVID-19
Authors: Gonzalez Suarez Maria Lourdes , Mara Kristin C. , Rivera Christina G. , Chesdachai Supavit , Draper Evan , Razonable Raymund R. 
Published: June 2024

Background and aim
Renal dysfunction is associated with poor outcomes in patients with coronavirus disease 2019 (COVID-19). In an effort to improve outcomes, intravenous remdesivir has been broadly used for the treatment of COVID-19 even in patients with low estimated glomerular filtration rate (eGFR). Our study assessed the residual risk of outcomes of patients with low eGFR despite treatment with remdesivir for COVID-19, during a timeframe prior to the expanded label across all levels of renal function.

Methods
We conducted an observational, retrospective, multi-site cohort study of adults hospitalized with COVID-19 treated with at least one dose of remdesivir between November 6, 2020, and November 5, 2021. Electronic medical records were reviewed to obtain patient characteristics, related laboratory data, and outcomes. The primary endpoint was all-cause mortality by day 28. Multivariable logistic regression was used to evaluate association between groups.

Results
The study population consisted of 3024 patients hospitalized with COVID-19 and treated with remdesivir. The median age was 67 [IQR 55, 77] years; 42.7% were women, and 88.6% were white. The median eGFR was 76.6 mL/min/1.73 m2 [IQR 52.5, 95.2]; the majority (67.2%) of patients had an eGFR ≥ 60, while 9% had an eGFR <30. All-cause mortality by day 28 was 8.7%. All-cause mortality rates were significantly higher among patients with impaired renal function (Odds Ratio [OR] 1.63 for patients with eGFR 30–59; OR 1.46 for eGFR 15–29; OR 2.42 for eGFR <15 and OR 5.44 for patients on dialysis) compared to patients with eGFR ≥60 mL/min/1.73m2.

Conclusions
Lower eGFR remains an independent risk factor for mortality in COVID-19 even in patients treated with remdesivir.
God Is Samoan: Dialogues between Culture and Theology in the Pacific, Matt Tomlinson (2020)
Authors: Prior Martin 
Published: June 2024

Review of: God Is Samoan: Dialogues between Culture and Theology in the Pacific, Matt Tomlinson (2020)
Honolulu, HI: University of Hawai‘i Press, 182 pp.,
ISBN 978 0 82488 097 2 (hbk), US$80
Financial Development is Supply-Leading or Demand-following? Empirical Investigation on EU Countries
Authors: Said Yasmeen , Hammam Rasha 
Published: June 2024

This study investigates the complex relationship between economic growth and financial development in 14 European nations from 2002 to 2020. This study compares supply-leading versus demand-following financial evolution assumptions using panel co-integration analysis and vector error correction models. To fully understand financial progress, the research integrates multiple variables. A complex and intricate link is shown by empirical evidence. Short-term supply-leading features include GDP to stock market capitalization and private sector credit. However, monetary liability growth follows demand. The long-term relationship between economic growth and private-sector loans is negative. This study shows that the causal relationship depends on the financial development index used. Additionally, the study distinguishes between transitory changes and lasting equilibrium connections. The study also found a dynamic association between financial development and economic growth as an economy matures. The supply-leading concept states that supply drives the stock market in early development. However, as the economy grows, a demand-following pattern arises, supporting the contradiction. This study offers a deep knowledge of the complex relationship between financial development and economic growth in Europe. The research uses powerful econometric tools and financial development indicators to demonstrate the importance of nuanced understanding for good policy making.
Supply-leading,Keywords: Economic Growth, Financial Development, Demand-following, Panel Cointegration, Vector Error Correction Model, Panel Causality
Threats and Benefits of AI in the context of targeting SDGs: A Youth Perception Approach
Authors: Isoieva Mariam , Marchenko Oleksandr , Diedkov Mykola , Lobanchuk Olena , Khrypko Svitlana 
Published: June 2024

This paper surveys the opinions of the young people on the potential of AI, namely in the context of targeting Sustainable Development Goals. The goal is to research how young people understand the threats and benefits of AI and what can be done to eliminate risks related to it. Survey results show that young people are concerned about the negative impacts AI can have on democracy, quality of education, spread of misinformation, etc. On the other hand, participants mention numerous positive opportunities coming from AI. Need for regulations for sustainable AI development is also discussed. Most of the respondents say that AI should be regulated by the government to ensure safe and ethical usage of it. Connections between the AI and Sustainable Development Goals from the perspective of the youth are drawn to tackle challenges and highlight opportunities.
Keywords: artificial intelligence, youth perspective, sustainable development goals, technologies development
Let’s entertain others: the relationship between comic styles and the histrionic self-presentation style in Polish, British, and Canadian samples
Authors: Fanslau Agnieszka , Olech Michał , Kałowski Piotr , Branowska Katarzyna , Zarazińska Anna , Glenwright Melanie , McGuinness Lauren , Banasik-Jemielniak Natalia 
Published: June 2024

Abstract
People who have the histrionic self-presentation style (HSP) demonstrate certain As-If-behaviors, involving pretense and role play, in their daily interactions to seek attention and amuse others. Doing As-If may be closely related to humor behaviors, so we examined this relationship in greater detail by using the Comic Style Markers (CSM) in Polish, English, and Canadian samples (N = 285, 383, and 305, respectively; M
age = 20.85, SD = 5.35). We expected that the HSP might be related to fun, wit, and satire due to their pretense-based characteristics. We confirmed configurational, metric, and scalar invariance for the As-If-Scale (AIS) and the CSM in the three samples, which allowed for cross-cultural comparisons. As expected, the HSP was positively associated with fun, wit, and satire. Additionally, men scored higher on the AIS, but no cross-country differences were found.
Fast and broadband spatial-photoresistance modulation in graphene–silicon heterojunctions
Authors: Du Ruxia , Wang Wenhui , Lin Huiwen , Zhang Xinlei , Wu Hao , Zhu Beibei , Jing Xu , Gu Xing , Ni Zhenhua , Tao Li 
Published: June 2024

Abstract
Different types of devices with modulable resistance are attractive for the significant potential applications such as sensors, information storage, computation, etc. Although extensive research has been reported on resistance effects, there is still a need for exploring new mechanisms that offer advantages of low power consumption, high sensitivity, and long-term stability. Here, we report a graphene–Si based spatial-dependence photo-rheostat (SDPR), which enables bipolar resistance modulation in the range of 5 mm with a resistance sensitivity exceeding 1,000 Ω/mm at operating wavelengths from visible to near infrared band (1,550 nm). Especially, at ultra-low energy consumption, the device can achieve modulation of even 5 orders of magnitude of resistance and response speed up to 10 kHz. A theoretical model based on carrier dynamics is established to reveal the diffusion and drift of carriers as a mechanism explaining such experimental phenomenon. This work provides a new avenue to modulate resistance at low power consumption as novel opto-potentiometers in various photoelectric applications.
Reconfigurable metasurface array for diverse retrodirective reflections and radar cross section reduction
Authors: Wei Wen Yue , Shi Yan , Meng Zan Kui , Hui Ru , Wu Quan Wei 
Published: June 2024

Abstract
Retroreflectors can scatter the arbitrarily incident wave back to incoming direction, demonstrating great potential in wireless communication. However, there are limitations in adaptive retroreflection and polarization modulation with the existing retroreflectors. In this paper, a novel metasurface array with a reconfigurable transmission line (TL) network has been proposed to flexibly achieve multiple manipulation functions of electromagnetic wave including upper half-space cross-polarized retroreflection and circularly polarized retroreflection in the diagonal planes and radar cross section (RCS) reduction. To accomplish these capabilities, a novel transmission mode for ferrite circulators has been developed, enabling precise phase control of the TL. By adjusting the operation states of the circulators, multiple phase differences between forward and reverse transmission directions including ±90° and ±180° are generated. With the obtained phase differences, the metasurface array can flexibly achieve the adaptive retroreflection fields with multiple polarization characteristics based on the spatial field superposition and the RCS reduction based on the phase cancellation. To validate the concept and feasibility of the proposed reconfigurable retrodirective metasurface, an X-band prototype has been fabricated and measured. Good agreement between the simulation and the experiment is observed to verify the effectiveness of our retrodirective design in upper half-space wave manipulation.
Zaštitno arheološko iskopavanje u Stinici
Authors: Glavaš Vedrana 
Published: June 2024

Tijekom svibnja 2022. godine provedeno je zaštitno arheološko istraživanje u luci u Stinici na području izgradnje tipskog sanitarnog čvora u luci. Istraživanje u Stinici je pokazalo da se i na ovom području rasprostire kulturni sloj koji se povezuje s razdobljem antičke Ortople.
Defect dynamics studies during heat treatments in plastically deformed metals predicted for nuclear applications
Authors: Siemek Krzysztof , Soyama Hitoshi , Wróbel Mirosław , Liedke Maciej Oskar , Butterling Maik , Wagner Andreas , Kulczyk Mariusz , Horodek Paweł 
Published: June 2024

AbstractWe report on defects dynamics during heat treatment in plastically deformed metallic materials using positron annihilation lifetime spectroscopy carried out on the intense pulsed positron beam. The conducted experiment allowed us to observe the changes in the concentration and sizes of vacancy-like defects observed during in situ annealing. We monitored heat treatments up to 300 °C in hydrostatic extruded Ti and cavitation peened V–4Cr–4Ti alloy. We were able to track the recovery processes in Ti and redistribution of large voids at the surface of cavitation peened V–4Cr–4Ti alloy. The relaxation time during recovery was about 20 min. Performed experiments show that in cold-worked metallic materials significant changes in vacancy clusters concentrations occur at mildly elevated temperatures. The presented results give opportunity to the application of in situ observation of defects dynamic to similar problems related to thermomechanical processing of metallic materials.
Graphical abstract
Antonio-Enrique Pérez Luño y Enrique Pérez-Luño Robledo, Deontología y abogacía
Authors: Sánchez Bravo Álvaro Avelino 
Published: June 2024

Este artículo reseña: Antonio-Enrique PÉREZ LUÑO y Enrique PÉREZ-LUÑO ROBLEDO, Deontología y Abogacía,Editorial Tirant lo Blanch, Valencia, 2022, 209 pp.
Los Juegos de la Paz: Prensa internacional y relaciones diplomáticas entre Corea del Norte y Corea del Sur durante los Juegos Olímpicos de Invierno de 2018
Authors: Simón Sanjurjo Juan Antonio , Gostian Laura , Asensio Castañeda Eva 
Published: June 2024

Los Juegos Olímpicos de Invierno celebrados en 2018 en la localidad surcoreana de Pyeongchang, se convirtieron durante varias semanas en el epicentro del diálogo diplomático y geopolítico internacional. La inesperada decisión de Corea del Norte de querer participar en este evento deportivo sólo un mes antes de la ceremonia de inauguración, provocó un sorprendente acercamiento diplomático con sus vecinos de Corea del Sur. Los medios de comunicación se consideran un poderoso instrumento capaz de influir en los comportamientos, actitudes y acciones a través de la transmisión de ideas, valores y normas. Esta investigación tiene como objetivo principal el identificar los discursos dominantes en torno a las relaciones diplomáticas entre Corea del Sur y Corea del Norte durante los Juegos Olímpicos de invierno del 2018, y analizar cómo se presentaron a través de la prensa de información general en España, Francia e Inglaterra. Se seleccionaron los periódicos españoles El País y El Mundo, los ingleses The Guardian y The Independent y los franceses Le Monde y Les Echos. Se realizó un análisis de contenido de 154 noticias divididas de la siguiente forma: prensa española 61, prensa inglesa 40 y prensa francesa 58. Los principales resultados mostraron cómo los medios de comunicación perpetuaron actitudes e ideas en torno a la identidad cultural y las relaciones diplomáticas en el deporte y los Juegos Olímpicos. Se aprecia un claro aumento en el número de noticias relacionadas con el tema de investigación en las semanas previas a los Juegos (sobre todo en la prensa española), mientras que durante el mes posterior al evento deportivo existe una clara reducción de noticias.
Incidence of and Risk Factors for Reoperation and Revision Following Total Elbow Arthroplasty with an Anatomic Convertible Prosthesis
Authors: Hill J. Ryan , Fadell Nick , Olson Jeffrey J. , Kahan Lindsey G. , Aleem Alexander W. , Keener Jay D. , Yamaguchi Ken , Zmistowski Benjamin M. 
Published: June 2024

Background:
Total elbow arthroplasty (TEA) remains a valuable tool for treating inflammatory, degenerative, and traumatic elbow conditions. This study aimed to understand the incidence of and risk factors for reoperation following TEA at a high-volume center utilizing an implant with a convertible linkage and the potential for anatomic lateral column reconstruction.

Methods:
All patients undergoing primary TEA with the Latitude prosthesis (Stryker) from July 2001 to May 2020 were identified. Patient characteristics, the surgical indication, and implant characteristics were obtained. Additionally, the indications and timing were identified for reoperations. Postoperative radiographs were analyzed to assess cement quality, implant position, lateral column reconstruction, and distal humeral bone loss.

Results:
Two hundred and nineteen TEAs were performed in 206 patients; 162 (74.0%) were in female patients, the mean patient age was 61 years (range, 23 to 95 years), and the mean follow-up was 11.8 years (range, 2 to 21 years). The most common indication for surgery was sequelae of trauma (36%). Ninety elbows (41.1%) required 200 reoperations at a mean of 19.6 months. Forty TEAs (18.3%) required revision of nonmodular implants, with 14 (6.4%) undergoing definitive explantation. The 5 and 10-year survivorship was 86.1% and 79.7%, respectively. The most common of the reasons for revision was aseptic loosening (53.8%), and the most common cause for non-revision reoperation was infection (23%). Younger age and greater follow-up duration were associated with greater revision and reoperation risks. Aseptic ulnar loosening was associated with a short ulnar stem length and component linkage (30% of short linked ulnar stems loosened; p < 0.001). Aseptic humeral loosening was associated with less-than-adequate cement-mantle quality (p = 0.04).

Conclusions:
Extended follow-up of the Latitude prosthesis at a high-volume center demonstrates that TEA continues to be hampered by a high reoperation rate, primarily due to infection and aseptic loosening. Technical factors such as good cement-mantle quality, longer stem length, and unlinked implants may play a role in preventing aseptic loosening. Further work is required to optimize long-term outcomes following TEA through improved understanding of appropriate surgical indications, techniques, and implant utilization.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Distribution and Functional Significance of KLF15 in Mouse Cerebellum
Authors: Li Dan , Cao Shuijing , Chen Yanrong , Liu Yueyan , Huo Kugeng , Shi Zhuangqi , Han Shuxin , Wang Liecheng 
Published: June 2024

Abstract

Kruppel-like factor 15 (KLF15), a member of the KLF family, is closely involved in many biological processes. However, the mechanism by which KLF15 regulates neural development is still unclear. Considering the complexity and importance of neural network development, in this study, we investigated the potent regulatory role of KLF15 in neural network development. KLF15 was detected highly expressed in the cerebellum and enriched in Purkinje cells, with a significant increase in KLF15 expression between 15–20 days of neural development. Knockdown of KLF15 led to loss of Purkinje cells and impaired motility in mice. Therefore, our study aims to elucidate the relationship between KLF15 and Purkinje cells in mice, may provide a new research idea for the developmental mechanism of the mouse cerebellum.