bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impaired mental health among the bereaved spouses of cancer patients
Authors: Asai Mariko , Akizuki Nobuya , Fujimori Maiko , Shimizu Ken , Ogawa Asao , Matsui Yutaka , Akechi Tatsuo , Itoh Kuniaki , Ikeda Masafumi , Hayashi Ryuichi , Kinoshita Taira , Ohtsu Atsushi , Nagai Kanji , Kinoshita Hiroya , Uchitomi Yosuke 
Published: May 2012

AbstractObjectiveFew cancer physicians routinely provide bereavement follow‐up in clinical practice. The purpose of this study was to identify the prevalence of impaired mental health among the bereaved spouses over several years and explore the indicators for early detection of high‐risk spouses during end‐of life (EOL) care.MethodsA cross‐sectional mail survey was conducted for the bereaved spouses of patients who had died at the National Cancer Center Hospital of Japan. Bereaved spouses with potential psychiatric disorders were identified by the cut‐off score of the 28‐item General Health Questionnaire. Associated factors of potential psychiatric disorders were explored by logistic regression analysis.ResultsA total of 821 spouses experiencing bereavement from 7 months to 7 years returned the questionnaires. Overall mean prevalence of potential psychiatric disorders was 44% (360/821). Bereaved spouses ‘under 55 years’ (71%) or ‘2 years after bereavement’ (59%) revealed a significantly higher prevalence (p < 0.01). Associated factors during EOL care were several characteristics such as ‘spouses’ history of psychiatric disorder (odds ratio (OR) = 3.19), ‘patients’ with stomach cancer (OR = 1.87), and ‘patients’ using psychiatric consultation services (OR = 1.52) as well as spouses’ dissatisfaction with EOL care such as ‘physicians’ treatment of physical symptoms’ (OR = 3.44) and ‘time spent communicating with patients’ (OR = 1.55).ConclusionsNearly half the bereaved spouses showed potential psychiatric disorders even 7 years after bereavement. Patients' psychological distress, spouses' history of psychiatric disorder, and dissatisfaction with EOL care were indicators of high‐risk spouses. Copyright © 2012 John Wiley & Sons, Ltd.
Effects of a supervised, outpatient exercise and physiotherapy programme in children with cystic fibrosis
Authors: Urquhart Donald , Sell Zoe , Dhouieb Elaine , Bell Gillian , Oliver Sarah , Black Ryan , Tallis Matthew 
Published: May 2012

AbstractPrevious work suggests benefit from outpatient exercise and physiotherapy in children with cystic fibrosis (CF), namely improved exercise capacity and lung function measures, as well reduced intravenous (IV) antibiotic needs. Our study aim was to investigate the effect of a year‐long supervised outpatient exercise and physiotherapy programme in children with CF. Subjects with CF aged ≥10 years who had received ≥4 courses of IV antibiotics in 2009 were enrolled and seen fortnightly for supervised exercise and physiotherapy throughout 2010. In addition, they were expected to exercise three times weekly, and if unwell complete additional physiotherapy sessions extra to usual chest physiotherapy. Assessments of exercise capacity using the Modified Shuttle Test (MST) and quality of life (QOL; CFQ‐UK) were recorded at baseline and after 1 year. Regular spirometry was performed before and throughout the study. Data were collected on IV antibiotic days. 12 subjects (6 female) were enrolled with mean (95% CI) age of 13.3 (11.8–14.6) years at study entry. A significant reduction in IV antibiotic days from 60 (56–64) days in 2009 to 50 (44–56) in 2010 (P = 0.02) was noted, along with improved MST distance (m) [735 (603–867) vs. 943 (725–1,161), P = 0.04] and level attained [9.4 (8.4–10.5) vs. 11.1 (9.6–12.6), P = 0.04]. Significant improvements in CFQ‐UK scores for physical [59 (47–72) vs. 83 (74–92), P = 0.001], emotional [63 (55–72) vs. 84 (74–93), P < 0.001], treatment [41 (30–51) vs. 61 (48–73), P = 0.002], and respiratory [54 (42–66) vs. 76 (70–82), P = 0.002] domains were noted. The mean (95% CI) rate of change of FEV1 was −4 (−18, +10)% in 2009, but was +6 (−2, +13)% in 2010, although this did not reach statistical significance. Supervised, outpatient exercise and physiotherapy are associated with improvements in QOL and exercise tolerance, a reduction in IV antibiotic days, and a trend towards reducing lung function decline in children with CF. The cost of IV antibiotics was reduced by £66,384 ($104,000) in 2010 when compared with 2009. Such cost‐benefit may have implications for workforce planning and service provision. Pediatr Pulmonol. 2012; 47:1235–1241. © 2012 Wiley Periodicals, Inc.
Nasopharyngeal oxygen with intermittent nose‐close and abdomen‐compression: A novel resuscitation technique in a piglet model
Authors: Soong Wen‐Jue , Jeng Mei‐Jy , Lee Yu‐Sheng , Tsao Pei‐Chen , Soong Yen‐Hui Matthew 
Published: May 2012

AbstractObjective: To evaluate the efficacy of a simple and novel cardiopulmonary resuscitation (CPR) technique, nasopharyngeal oxygen with intermittent nose‐close and abdomen‐compression (NPO2‐NC‐AC) in an animal model. Design: Prospective piglet study. Setting: In an animal physiology laboratory of a medical university. Piglets: Six healthy piglets <14 days old. Interventions: Spontaneous breathing of the anesthetized piglets (n = 6) was medically ceased until severe bradycardia (<20 beat/min). NPO2‐NC‐AC CPR trial was then initiated by delivering NPO2 at 1.0–1.5 L/kg/min and intermittently performing the NC‐AC maneuver: (1) NC for inspiration, occluded nostrils for 1 sec; and (2) AC for expiration, released nostrils, and compressed the abdomen for 1 sec. NC‐AC was repeated at a rate of 30/min for 5 min. This CPR trial was repeated three times in each piglet. Cardiopulmonary variables were monitored, recorded, and compared. Measurements and Main Results: A total of 18 CPR trials were performed. All of these acute life‐threatening asphyxia events rapidly improved within 1 min of CPR. Cardiopulmonary variables recovered to the baseline levels and oxygenation continually increased. The intratracheal pressure (Ptr) values of positive end expiratory pressure and peak inspiratory pressure values were 4.3 ± 0.8 cmH2O and 26.2 ± 4.1 cmH2O, respectively. Chest wall movement was observed when the Ptr reached 17.5 ± 3.1 cmH2O. All six piglets fully recovered after 63.8 ± 7.2 min of experiment without additional support. Conclusions: NPO2‐NC‐AC is a simple and effective CPR technique for severe acute cardiopulmonary asphyxia in piglets. It may be clinically applicable for supportive or rescue use. Pediatr Pulmonol. 2013; 48:288–294. © 2012 Wiley Periodicals, Inc.
Transient interactions of a slow‐folding protein with the Hsp70 chaperone machinery
Authors: Sekhar Ashok , Santiago Margarita , Lam Hon Nam , Lee Jung Ho , Cavagnero Silvia 
Published: May 2012

AbstractMost known proteins have at least one local Hsp70 chaperone binding site. Does this mean that all proteins interact with Hsp70 as they fold? This study makes an initial step to address the above question by examining the interaction of the E.coli Hsp70 chaperone (known as DnaK) and its co‐chaperones DnaJ and GrpE with a slow‐folding E.coli substrate, RNase HD. Importantly, this protein is a nonobligatory client, and it is able to fold in vitro even in the absence of chaperones. We employ stopped‐flow mixing, chromatography, and activity assays to analyze the kinetic perturbations induced by DnaK/DnaJ/GrpE (K/J/E) on the folding of RNase HD. We find that K/J/E slows down RNase HD's apparent folding, consistent with the presence of transient chaperone‐substrate interactions. However, kinetic retardation is moderate for this slow‐folding client and it is expected to be even smaller for faster‐folding substrates. Given that the interaction of folding‐competent substrates such as RNase HD with the K/J/E chaperones is relatively short‐lived, it does not significantly interfere with the timely production of folded biologically active substrate. The above mode of action is important because it preserves K/J/E bioavailability, enabling this chaperone system to act primarily by assisting the folding of other misfolded and (or) aggregation‐prone cellular proteins that are unable to fold independently. When refolding is carried out in the presence of K/J and absence of the nucleotide exchange factor GrpE, some of the substrate population becomes trapped as a chaperone‐bound partially unfolded state.
Genetic polymorphism and prostate cancer aggressiveness: A case‐only study of 1,536 GWAS and candidate SNPs in African‐Americans and European‐Americans
Authors: Bensen Jeannette T. , Xu Zongli , Smith Gary J. , Mohler James L. , Fontham Elizabeth T.H. , Taylor Jack A. 
Published: May 2012

AbstractBACKGROUNDGenome‐wide association studies have established a number of replicated single nucleotide polymorphisms (SNPs) for susceptibility to prostate cancer (CaP), but it is unclear whether these susceptibility SNPs are also associated with disease aggressiveness. This study evaluates whether such replication SNPs or other candidate SNPs are associated with CaP aggressiveness in African‐American (AA) and European‐American (EA) men.METHODSA 1,536 SNP panel which included 34 genome‐wide association study (GWAS) replication SNPs, 38 flanking SNPs, a set of ancestry informative markers, and SNPs in candidate genes and other areas was genotyped in 1,060 AA and 1,087 EA men with incident CaP from the North Carolina‐Louisiana Prostate Cancer Project (PCaP). Tests for association were conducted using ordinal logistic regression with a log‐additive genotype model and a 3‐category CaP aggressiveness variable.RESULTSFour GWAS replication SNPs (rs2660753, rs13254738, rs10090154, rs2735839) and seven flanking SNPs were associated with CaP aggressiveness (P < 0.05) in three genomic regions: One at 3p12 (EA), seven at 8q24 (5 AA, 2 EA), and three at 19q13 at the kallilkrein‐related peptidase 3 (KLK3) locus (two AA, one AA and EA). The KLK3 SNPs also were associated with serum prostate‐specific antigen (PSA) levels in AA (P < 0.001) but not in EA. A number of the other SNPs showed some evidence of association but none met study‐wide significance levels after adjusting for multiple comparisons.CONCLUSIONSSome replicated GWAS susceptibility SNPs may play a role in CaP aggressiveness. However, like susceptibility, these associations are not consistent between racial groups. Prostate 73: 11–22, 2013. © 2012 Wiley Periodicals, Inc.
The crystal structure of dihydrodipicolinate synthase from Escherichia coli with bound pyruvate and succinic acid semialdehyde: Unambiguous resolution of the stereochemistry of the condensation product
Authors: Boughton Berin A. , Dobson Renwick C. J. , Hutton Craig A. 
Published: May 2012

AbstractThe crystal structure of Escherichia coli dihydrodipicolinate synthase with pyruvate and substrate analogue succinic acid semialdehyde condensed with the active site lysine‐161 was solved to a resolution of 2.3 Å. Comparative analysis to a previously reported structure both resolves the configuration at the aldol addition center, where the final addition product clearly displays the (S)‐configuration, and the final conformation of the adduct within the active site. Direct comparison to two other crystal structures found in the Protein Data Bank, 1YXC, and 3DU0, demonstrates significant similarity between the active site residues of these structures. Proteins 2012; © 2012 Wiley Periodicals, Inc.
Electrical characterization of 4H‐SiC Schottky diodes with RuWOx Schottky contacts before and after irradiation by fast electrons
Authors: Benkovska Jana , Stuchlikova Lubica , Buc Dalibor , Čaplovic Lubomir 
Published: May 2012

AbstractThe impact of radiation damage on the device performance of 4H‐SiC Schottky barrier diodes (SBDs) with RuWOx Schottky contacts, which were irradiated at room temperature with 9 MeV electrons (absorbed dose of 50 Gy), is studied by current–voltage (I–V) and capacitance–voltage (C–V) methods measured in the temperature range of 85–400 K. We have observed the radiation‐induced decrease of the Schottky barrier height (SBH) from original Φb = 1.13–1.06 eV, increase of the ideality factor from n = 1.14 to 1.39 and the noticeable increase of the saturation current from IS = 7.29 to 77.31 pA and the series resistance from RS = 2.9 to 7.9 Ω calculated from I–V measurements at T = 300 K. As a result of electron irradiation deep energy levels originated in the structure and caused the increase of serial resistance and leakage current. The DLTS results have shown several deep energy levels, e.g., EC – 0.637 eV pointing to radiation‐induced Z1/2 structural defects in SiC. No degradation is observed from the measured C–V curves. The experimental value of the effective Richardson constant A* = 50.68 A/cm2/K2 for the irradiated sample was calculated from the modified Richardson plot.
Formation of aluminum tris (8‐hydroxyquinoline) solution in methanol and fabrication of thin films by ultrasonic spray‐assisted vapor deposition
Authors: Piao Jinchun , Katori Shigetaka , Ikenoue Takumi , Fujita Shizuo 
Published: May 2012

AbstractSmall molecular material, aluminum tris (8‐hydroxyquinoline) (AlQ3), was found to be soluble in methanol under application of high ultrasonic power, and this has opened safe and environmental‐friendly solution‐based deposition of thin films. The chemical state of AlQ3 was analyzed by nuclear magnetic resonance study and the results showed there was no severe damage on AlQ3 atoms applied by high ultrasonic power. The AlQ3 films were fabricated by ultrasonic‐assisted mist deposition method on indium‐tin‐oxide. The low leakage current suggested well‐defined AlQ3 thin films without significant electrical defects such as pinholes.
Unusual behaviour of wave propagation in auxetic structures: P‐waves on free surface and S‐waves in chiral lattices with piezoelectrics
Authors: Malischewsky Peter G. , Lorato Andrea , Scarpa Fabrizio , Ruzzene Massimo 
Published: May 2012

AbstractWe examine some unusual wave propagation characteristics related to auxetic systems represented by continuum isotropic materials and hexagonal chiral lattices with and without active piezoelectric actuation. We show for the first time a peculiar singularity in the ratio between reflected P and S waves in Rayleigh‐wave type propagation for auxetic isotropic materials, which has been otherwise observed only in at least bi‐phase material systems. The other unusual phenomenon is a strong increase of the pass‐stop band frequencies in hexachiral lattices with piezoelectric materials, with no change of the shear‐wave type otherwise occurring in pristine lattice with no piezoelectric contribution.
Magnetic properties of Ni3B2O6 and Co3B2O6 single crystals
Authors: Bezmaternykh L. N. , Sofronova S. N. , Volkov N. V. , Eremin E. V. , Bayukov O. A. , Nazarenko I. I. , Velikanov D. A. 
Published: May 2012

AbstractOrthorhombic Me3B2O6 (Me = Co, Ni) single crystals of the kotoite family are grown from the fluxes based on a mixture of bismuth trimolybdate and sodium oxide upon spontaneous nucleation. The field and temperature dependences of magnetization of the single crystals with the magnetic field oriented along the principal crystallographic directions are obtained. Unlike Ni3B2O6, Co3B2O6 exhibits strong anisotropy of the magnetic properties. At the temperature T = 10 K, the magnetization curves of Co3B2O6 reveal an anomaly attributed to the spin‐reorientation transition. Strong anisotropy of the magnetic properties of Co3B2O6 is also confirmed by the calculation of the exchange interactions within a simple indirect coupling model.
Effects of purification on the diameter separation of metallic single‐walled carbon nanotubes by gel column chromatography
Authors: Zhang Jing , Tan Furui , Li Hongbo , Jin Hehua , Li Qingwen 
Published: May 2012

AbstractMetallic single‐walled carbon nanotubes (m‐SWCNTs) with excellent conductivity and transparency are considered to be eminent electrode materials. However, it still remains a challenge to separate m‐SWCNTs by their diameters. As reported in this Letter, by effective purification treatment of SWCNTs, we succeeded in achieving diameter separation of m‐SWCNTs using gel column chromatography. TEM and Raman characterizations revealed that metal catalysts and amorphous carbon on tube surfaces were largely reduced, which contributed to the diameter separation of m‐SWCNTs.magnified imageThe separation process of m‐SWCNTs by gel column chromatography and their corresponding optical absorption spectra.(© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Design of a class of nonlinear consensus protocols for multi‐agent systems
Authors: Xu Yaojin , Tian Yu‐Ping 
Published: May 2012

SUMMARYThis paper investigates the consensus problem for multi‐agent systems and presents a class of nonlinear consensus protocols. First, we reveal some structure property of the corresponding Laplacian matrix by decomposing the interaction graph into strongly connected components. Then, by means of the input‐to‐state stability and algebraic graph theory, we propose a framework to prove consensus for multi‐agent systems with nonlinear protocols. In particular, we prove that consensus can be always reached in systems of single‐integrator agents with a directed communication topology containing a spanning tree, provided the nonlinear protocol is an odd and increasing function. The nonlinear consensus protocols proposed in this paper include the classical linear consensus protocol as a special case, and may have a wide range of applications, including consensus with faster convergence rates and with bounded control inputs. Copyright © 2012 John Wiley & Sons, Ltd.
Evaluation of Tribological Behavior of Al‐Co‐Cr‐Fe‐Ni High Entropy Alloy Using Molecular Dynamics Simulation
Authors: Huang Jen‐Ching 
Published: May 2012

SummaryHigh‐entropy alloys have been studied extensively for their excellent properties and performance, including outstanding strength and resistance to oxidation at high temperatures. This study employed molecular dynamics simulation to produce a high‐entropy alloy containing an equal molar ratio of Al, Co, Cr, Fe, and Ni and investigated the tribological behavior of the material using a diamond tool in a vacuum environment. We also simulated a AlCoCrFeNi high‐entropy alloy cooled from a high temperature molten state to 300 K in a high‐speed quenching process to produce an amorphous microstructure.In a simulation of nanoscratching, the cutting force–distance curve of high‐entropy alloys was used to evaluate work hardening and stick–slip. An increase in temperature was shown to reduce the scratching force and scratching resistance. Nanoscratching the high‐entropy alloy at elevated temperatures provided evidence of work hardening; however, the degree of work hardening decreased with an increase in temperature. And it can also be found that when the temperature is higher, the fluctuation of the cutting force curve is greater. SCANNING 34: 325–331, 2012. © 2012 Wiley Periodicals, Inc.
Micro‐Raman Spectroscopy Study of Human Pterygium and Conjunctival Melanocytic Nevi
Authors: Zhuang Zhengfei , Ke Xiong , Guo Zhouyi , Chen Sijin , Li Ning 
Published: May 2012

SummaryPterygium, a common ophthalmic disease that is caused by fibrovascular growth of conjunctiva and conjunctival melanocytic nevi that is another conjunctival disease, are detected by Raman spectroscopy in the present study. We find that there is an obvious increase in the intensity at the peak of 1,583 cm−1 that is assigned to C=C unsaturated fatty acids stretch of lipids in the pterygium tissue, and 1,639 cm−1 also increased which belongs to amide I. Also, PCA (Principal Component Analysis) was used to classify the normal conjunctiva from the pterygium tissue. For the conjunctival melanocytic nevi, the intensity of Raman spectrum region between 1,550 cm−1 and 1,650 cm−1 that belong to protein has increased, which indicates that the content of protein in conjunctival melanocytic nevi is more richer than the normal ones. SCANNING 34: 395–398, 2012. © 2012 Wiley Periodicals, Inc.
Fractal Analysis of Two‐Photon Microscopic Images for Diagnosis of Nasopharyngeal Cancer
Authors: Huang Zufang , Pan Jianji , Chen Guannan , Li Zuanfang , Chen Xiwen , Li Yongzeng , Wang Jing , Chen Rong 
Published: May 2012

SummaryIn this study, two‐photon microscopy (TPM) was applied to obtain high‐resolution, optically sectioned images with cellular morphology information from normal and cancerous nasopharyngeal tissue. Notable difference of nuclear‐cytoplasmic ratio was found between these two groups. In particular, fractal dimension (FD) analysis based on TPM images showed good differentiation between normal and cancerous nasopharyngeal tissues. Our results indicate that TPM coupled with FD analysis methods has the potential to extract diagnostic features for label‐free histological diagnosis. SCANNING 34: 399‐403, 2012. © 2012 Wiley Periodicals, Inc.
The Effect of Thermal Oxidation on the Luminescence Properties of Nanostructured Silicon
Authors: Liu Lijia , Sham Tsun‐Kong 
Published: May 2012

AbstractHerein is reported a detailed study of the luminescence properties of nanostructured Si using X‐ray excited optical luminescence (XEOL) in combination with X‐ray absorption near‐edge structures (XANES). P‐type Si nanowires synthesized via electroless chemical etching from Si wafers of different doping levels and porous Si synthesized using electrochemical method are examined under X‐ray excitation across the Si K‐, L3,2‐, and O K‐edges. It is found that while as‐prepared Si nanostructures are weak light emitters, intense visible luminescence is observed from thermally oxidized Si nanowires and porous Si. The luminescence mechanism of Si upon oxidation is investigated by oxidizing nanostructured Si at different temperatures. Interestingly, the two luminescence bands observed show different response with the variation of absorption coefficient upon Si and O core‐electron excitation in elemental silicon and silicon oxide. A correlation between luminescence properties and electronic structures is thus established. The implications of the finding are discussed in terms of the behavior of the oxygen deficient center (OCD) and non‐bridging oxygen hole center (NBOHC).
MASH: tool integration made easy
Authors: Mariani L. , Pastore F. 
Published: May 2012

SUMMARYIntegrating tools implemented as plug‐ins is a complex and time‐consuming activity that requires good programming skills and a deep understanding of the underlying plug‐in architecture for successful completion. Even when tools are implemented as plug‐ins for a same integrated development environment (IDE), users frequently prefer to manually perform the same inefficient operations every time they use the tools rather than implementing automated tool integration.In our vision, IDE users must be able to flexibly execute plug‐ins and easily integrate their results by designing workflows that can be persisted, automatically executed, and reused in other workflows.This paper therefore presents MASH, a framework that extends IDEs with task‐based plug‐ins (TB‐plug‐ins) and workflows. A TB‐plug‐in is a plug‐in that exposes its functionalities as executable tasks in a workflow. TB‐plug‐in workflows are processes that automatically execute multiple tools and integrate their results. IDE users can turn regular plug‐ins into TB‐plug‐ins by writing simple scripts or using the GUI capturing feature that MASH offers.We validated our idea with two case studies examining the design of two data‐driven analyses as tool integration. We discovered that workflows can be easily designed by knowing little about the IDE or plug‐ins API, saving significant effort otherwise devoted to implementing additional plug‐ins and glue code, and they produce analyses that can be quickly modified and reused. Copyright © 2012 John Wiley & Sons, Ltd.