bluuebunny/crossref_metadata_2025_split huggingface dataset:
Input‐Based Adaptive Event‐Triggered Control Under a Network Resource‐Constrained Environment
Authors: Sahu Poonam , Fulwani Deepak 
Published: February 2025

ABSTRACTThe work proposes an input‐based event‐triggered mechanism with parameterized low‐gain feedback for a discrete‐time system under a network resource‐constrained environment. The control input depends on a parameter , which can be adaptively scheduled according to the network conditions. The control input is designed using the seminal concept of low‐gain feedback. Further, we establish an explicit relation between inter‐event time and the control parameter. Stability with the proposed triggering rule is established, and the proposed theory is verified using an active suspension system.
Inclusive Dialog With Local Communities: Practices Among Professionals and the Battle for Equity and Public Engagement in Science Museums and Science Centers
Authors: dos Santos e Menezes Débora Teixeira , Bevilaqua Diego Vaz , Silva Douglas Falcão 
Published: February 2025

ABSTRACTThis study aimed to understand the actions carried out for dialog between science centers and science museums with the public of local communities living in a situation of socioeconomic vulnerability. The study adopted a quantitative and qualitative approach and the theoretical framework of science communication, of the exercise of citizenship and of engagement with science, using concepts such as Technoscientific Citizenship, Social Appropriation of Science and Technology, and Science Capital. Also, a few previous visitor studies on the same purpose of inclusion and social equity were considered. The methodology involved the participation of professionals who work in Brazilian institutions, in two stages of data collection, both carried out online. Initially, a questionnaire was answered by 69 professionals, of whom nine took part in in‐depth interviews. The qualitative data was analyzed using the Discourse of the Collective Subject (DCS) method, from which the results have been presented in three Categories and twelve Synthesis‐Speeches. The establishment of a dialog with a broader public involves taking on a long‐term institutional commitment, developing broad access mechanisms with respect to cultural differences. It is fundamental to make constant and careful efforts to welcome a diverse public and meet the challenge of breaking down prejudices. The implementation of the social role of science centers and science museums not only democratize knowledge but promotes a freedom feeling and the raise of self‐esteem of those who engage in its activities. The results corroborated previous studies, stating that to build a legacy and to foster significant changes in the profile of the audience, the social exclusion needs to be treated as a structural, complex, and multifaceted issue.
XPS Insight Note: Multiplet Splitting in X‐Ray Photoelectron Spectra
Authors: Isaacs M. A. , Graf A. , Morgan D. J. 
Published: February 2025

ABSTRACTPhotoelectron spectra can be complicated by the presence of final state effects, leading to the misinterpretation of spectra especially by analysts new to the field. In this insight note, we present a précis on the topic of multiplet splitting, a phenomenon that can produce—especially when coupled with the presence of shake‐satellites—complex spectra that may be readily misinterpreted by those new to the field of X‐ray photoelectron spectroscopy.
Isolation and Characterization of an Insulin‐Like Protein From Moringa Oleifera and Estimation of Its Antidiabetic Potential
Authors: Zaib Sumera , Khan Imtiaz , Babar Laiba , Naseer Nawal , Nadeem Danial , Fatima Ravish , Dera Ayed A. , Jaber Fadi , Rahman K.K. Mujeeb 
Published: February 2025

AbstractMoringa oleifera is used all over the world as an herbal cure for a myriad of diseases. The current research focuses on the extraction of proteins from Moringa oleifera leaves, estimating their total protein content, detecting an insulin‐like protein, and evaluating its hypoglycemic effect. With the help of a Tris‐HCl buffer solution, the leaf protein extract is obtained through solvent extraction, which is subjected afterward to filtration, centrifugation, and dialysis to provide the purified supernatant and pellet. A total protein content of 8.0 ± 0.25 g/dL in both fractions is revealed by the serum albumin assay. A visible precipitation with ZnCl2 confirms the presence of an insulin‐like protein. Alpha‐amylase and alpha‐glucosidase enzyme assays are performed to test their hypoglycemic properties. Notably, the protein extract displays strong inhibition against α‐amylase, having percentage inhibition values of 75.48 and 82.93% and relevant IC50 values of 0.6 and 17.6 µM for supernatant and pellet, respectively. However, α‐glucosidase inhibition is modest, with 11.1 and 14.1% for supernatant and pellet, respectively. These findings suggest that the insulin‐like protein within the Moringa oleifera leaf protein extract can contribute to its hypoglycemic effect. This study paves the way for further exploration of this protein's potential, possibly leading to novel drug development for managing diabetes mellitus.
Construction of a Multifunctional Nanodrug Delivery System Based on Tirapazamine and Glucose Oxidase: Its Antitumor Activity
Authors: Shi Xiandong , Li Xu , Liu Baoqing , Zhang Jingyi , Zhai Wenhao , Luan Yanfei , Zhou Jiahong , Zhou Xiang 
Published: February 2025

AbstractAiming at the defects in the clinical application of tirapazamine (TPZ), this paper reports a GOX‐TPZ‐CaP@SA nanodrug delivery system. The nanodrug delivery system can enter the lysosomes of tumor cells through endocytosis. The acidic environment of the lysosomes induces the release of TPZ and glucose oxidase (GOX). When GOX catalyzes the glucose, the oxygen consumption is intensified in tumor tissues, providing suitable environmental conditions for TPZ. Research data indicate that the synergistic effect between TPZ and GOX improves the antitumor performance of the nanodrug delivery system.
Household Post‐Consumer Flexible Plastic Recycling–The Significance of Compatibilizers and Reinforcing Fillers
Authors: Nguyen Thi Hanh Tien , Cong Nguyen Thanh , Zurbrügg Christian , Dung Trinh Thi Tuyet , Ly Quang Viet , Huong Ngo Thi Thuy , Le Thanh Thao , Quang Dang Viet 
Published: February 2025

AbstractHousehold post‐consumer flexible plastic (PCFP) consisting of films and bags is currently unattractive for recycling because of contamination. The success of recycling strategy depends on the selection of compatibilizers and fillers; however, their influence on the properties of resulting products has not been systematically reviewed. This review will analyze their impact on the mechanical properties of resulting composites and provide fundamental guidelines for the selection of compatibilizers and fillers. The addition of virgin polymer or copolymer improves the elongation at break of the composite, but it is significantly below that of original flexible plastic. Polyolefin grafted with maleic anhydride appears to be the best option for enhancing both tensile strength and modulus, achieving improvements of approximately 28.0% and 22.0%, respectively. Further enhancements can be achieved with the addition of natural fibers such as jute, corn, and piassava. For instance, jute fiber can increase tensile strength and modulus by approximately 30.6% and 160.8%, respectively. Nanomaterials also hold great potential; incorporating graphene into recycled high‐density polyethylene can enhance tensile strength and modulus by approximately 56.4% and 125.0%, respectively. Clearly, composite production represents the most viable option for PCFP recycling, where the selection of compatibilizers and fillers should play a decisive role.
Catalyst‐Free Synthesis of Substituted Thiazole‐2‐Imine Derivatives in a Mortar, and Their Photophysical Study
Authors: Mohurle Shital , Maiti Barnali 
Published: February 2025

AbstractIn this study, for the first time we devised a one‐pot telescopic method for synthesizing thiazol‐2(3H)‐imine using mortar‐pestle grinding under solvent‐free conditions. The reaction involves isothiocyanate, primary amine, and α‐bromoketones as precursors. The protocol demonstrated a broad substrate scope of 19 derivatives confirmed by various spectroscopic techniques. The reported approach is simple to operate, has mild reaction conditions, and affords the desired products in good to outstanding yields up to 98% in 10 to 20 min. UV‐visible and fluorescence spectroscopic techniques were used to investigate the photophysical characteristics of 9 selected thiazol‐2(3H)‐imine derivatives. The absorption and emission spectra show a maximum peak wavelength (λmax) at 295 ̶ 305 nm and 369 ̶ 370 nm, respectively.
Synthesis, Anti‐enzymatic Appraisal, In Silico, and SAR Analysis of 5‐Aryl/Heteroaryl‐2,2‐dimethyl‐1,3‐dioxane‐4,6‐dione Derivatives
Authors: Khatoon Saira , Mehfooz Haroon , Shehzadi Syeda Aaliya , Saeed Aamer , Kalsoom Saima , Channar Pervaiz Ali , Ismail Hammad , Rauf Abdul , Naveed Sana , Taslimi Parham , El‐Seedi Hesham 
Published: February 2025

AbstractA sequence of new 5‐aryl/heteroaryl‐2,2‐dimethyl‐1,3‐dioxane‐4,6‐dione derivatives were synthesized by condensing Meldrum's acid and triethyl orthoformate with differently substituted aromatic and heteroaromatic amines in good to excellent yields. The chemical structures were characterized by spectroscopic techniques and the synthesized entities were evaluated for chymotrypsin and urease inhibition. Interestingly, among the synthesized derivatives, compound containing 5‐nitropyridin‐2‐yl ring exhibited dual inhibition activities with IC50 value (8.67 ± 0.1) close to the control (Chymostatin:8.24 ± 0.11) against chymotrypsin; and (29.21 ± 0.98) close to the control (Thiourea:21.25 ± 0.15) urease in µM concentration. Further, molecular docking analysis was performed on the 3D crystal structure of Jack bean urease protein and a serine proteinase α‐chymotrypsin with synthesized ligands, to observe the binding interactions. All the synthesized compounds docked well into the active sites of the proteins, the most active compound showed H‐bonding interaction with amino acid HIS A 594 residue through carbonyl oxygen of dioxane ring and CME A 592 through oxygen of nitro group against 3La4 urease protein, while against chymotrypsin, it revealed the hydrogen bonding between amino acids: SER C 217, GLY C 216, and SER C 190. The role of pharmacophore was evaluated using the diverse substituents on aromatic/heteroaromatic rings, and on the basis of that SAR was developed.
Tailored rGO@Fe3O4 and rGO@Co3O4 Nanocomposites for Treatment of Organic Toxic Effluents: Modeling, Optimization, Kinetics, and Recyclability Evaluation
Authors: Kanwal Amina , Shahzadi Tayyaba , Riaz Tauheeda , Iqbal Javed , Bedowr Noha Said 
Published: February 2025

AbstractWater pollution has emerged as an important concern because polluted water damages the whole ecosystem. In order to prevent the loss of contaminated water, reduced graphene oxide‐based materials i.e rGO@Fe3O4 and rGO@Co3O4 have been synthesized. Synthesized nanomaterials were characterized by different techniques like UV–visible spectroscopy, EDX, and XRD spectroscopy, which confirmed the synthesis of rGO@Fe3O4 and rGO@Co3O4 with average size of 3.34 and 3.07 nm, respectively. Functional groups involved in synthesis and stabilization of nanocomposites were identified by FTIR spectrophotometry, while crystalline structure was depicted by SEM. By optimizing different factors maximum % removal of dyes i.e 96% and 94% by rGO@Fe3O4 for rhodamine B and alizarin R, respectively, and 94% and 92% by rGO@Co3O4 for rhodamine B and alizarin R, respectively, within contact time of 20 min were observed under tungsten lamp. Kinetics study revealed adsorption mechanism followed by pseudo 2nd order reaction as R2 values of both dyes were 0.98 and 0.99 with synthesized nanomaterials. Freundlich isotherm was best‐fitted isotherm, and thermodynamics study described the spontaneity and endothermic nature of adsorption mechanism. Reusability of synthesized materials was analyzed about 5 times, and hydroxyl radicals involved in photocatalytic degradation, was examined through different types of scavengers.
A New Cu2+‐Binding 1,3‐Benzodioxole‐Contaning N‐Acylhydrazone Protects Saccharomyces cerevisiae Cells from Oxidative Stress
Authors: Barbosa Barbara Marinho , Pires Daniele C. , Galvácsi Antal , Gaudard Anna Júlia , Flores Leonã S. , Sánchez‐López Carolina , Correa Charlane C. , Cukierman Daphne S. , Hureau Christelle , Kállay Csilla , Pereira Marcos D. , Quintanar Liliana , Rey Nicolás A. 
Published: February 2025

AbstractCopper dyshomeostasis is related to an increase in oxidative stress that, in turn, has been associated with a myriad of diseases and physiological aging. Based on this, the study of compounds with moderate affinity for this biometal is of interest. In this scenario, a new, highly stable, and non‐toxic (assessed in S. cerevisiae) 1‐methylimidazole‐containing N‐acylhydrazone, HX1Diox, is synthesized and characterized, including by XRD. The compound forms complexes of 1:1 and 1:2 copper(II)‐to‐ligand stoichiometries in solution, while only the non‐charged 1:2 compound, [Cu(X1Diox)2], is isolated in the solid state. In this case, each hydrazone unit is fully deprotonated and coordinates, in the iminolate X1Diox− form, as an N2O‐ meridional tridentate ligand. The soluble cationic species [Cu(X1Diox)(OH2)x]+ and [Cu(HX1Diox)(X1Diox)]+ are detected solely in solution, and stability constants of 12.49(4) and 28.42(6) are determined, respectively, for each of them. Interestingly, HX1Diox shows promising activity as a scavenger of superoxide radical anions, assessed in vitro, and eukaryotic cells by using wild‐type and SOD1‐deficient strains of S. cerevisiae yeast. Altogether, these results point to a promising copper interaction profile of HX1Diox, which, coupled with its favorable antioxidant profile, encourages further studies in the context of ROS‐related diseases.
Surface‐Functionalized ZnO Quantum Dot Fillers for Silicone Rubber Composites with Enhanced Antibacterial Performance
Authors: Xie Xinxin , Jiang Peilong , Ma Wenqiang , Feng Chao , Cai Lifan , Zhu Guiyou , Guo Jianwei 
Published: February 2025

AbstractZnO QDs (zinc oxide quantum dots) have potential value in the field of silicone rubber due to their excellent antimicrobial properties. However, the poor dispersion of ZnO QDs in silicone rubber limits their application. The surface functionalization of ZnO QDs can improve their dispersion in silicone rubber. This study showed that the surface of ZnO QDs could be effectively functionalized by using different kinds of silane coupling agents KH550 (3‐aminopropyltriethoxysilane), KH570 (3‐acryloyloxypropyltrimethoxysilane), KH580 (3‐mercaptopropyltriethoxysilane), A151 (vinyltriethoxysilane) and HD128 (phenyltriethoxysilane). The surface‐functionalized ZnO QDs show a reduction in particle size to 4–5 nm. The number and size of agglomerated particles on the surface of surface‐functionalized ZnO QDs/RTV (room temperature vulcanized silicone rubber) composites were significantly reduced. Meanwhile, the surface roughness decreased by 92.10% (KH550), 93.08% (KH570), 91.36% (KH580), 85.43% (A151), and 90.86% (HD128), respectively, and the viscosity was increased by 2.90% (KH550), 4.35% (KH570), 2.90% (KH580), 1.54% (A151), and 3.62% (HD128), respectively. ZnO QDs‐KH570 has the best dispersion effect. Furthermore, the antibacterial rate of ZnO QDs‐KH570/RTV against Escherichia coli and Staphylococcus aureus achieved 99.9% when the additional amount of ZnO‐KH570 QDs was 0.1%, which indicated excellent antibacterial performance and could contribute to the development of silicone rubber medical supplies.
Thermal Management Applications of Phase Change Microcapsules with the PDA‐Modified TiO2 as a Multilayered Shell
Authors: Cheng Han , Tang Bo , Bao Huayang , Shan Fan , Lu Chunxu , Yan Fubin 
Published: February 2025

AbstractThe novel multilayer shell phase change microcapsule (NePCM), which consists of paraffin/titanium dioxide‐polydopamine (PW/TiO2‐PDA), is prepared by a two‐step method. The PDA deposits on the TiO2 surface through self‐polymerization of dopamine (DA). The NePCM5 and NePCM‐PDA‐0.6 samples have maximum phase change enthalpies of 106.43 and 80.12 J g−1, respectively. There is no trend of continuous increase in phase change enthalpy with increasing PDA content, which may attribute to the agglomeration behaviors caused by the excessive PDA content. The PW encapsulated within the microcapsules maintains stable phase change performances during the storage and release processes of thermal energy. The as‐prepared microcapsules show regular monolayer and multilayer spherical core‐shell structures. The average size of the NePCM5 and NePCM‐PDA‐0.6 samples are approximately 259.4 and 311.4 nm, respectively. The particle size of nanoscale microcapsules is advantageous for improving heat transfer efficiency, maintaining uniform distribution, optimizing mechanical properties, and reducing phase change lag of thermal storage systems (TES) in industrial applications. The obtained microcapsules are applied to modify thermal insulation coatings based on the low thermal conductivity of the PW. The maximum temperature difference and the lowest thermal conductivity reach 19.70 °C (5 mm) and 0.126 W (m·K)−1 (5 mm) after adding the NePCM‐PDA‐0.6. The resulting coating have a high stability, low thermal conductivity, superior mechanical strength, high heat storage and heat preservation effect. Therefore, the stability of the PW can be further enhanced and the thermal conductivity of PW/TiO2 microcapsules is reduced by coating the TiO2 shell layer. The double‐shell microcapsules possess distinct advantages and wide application prospects in coatings, construction and textiles fields.
Method for Increasing the Porosity of Anodic TiO2 Nanotubes by Anodization in Short Time
Authors: Li Xiaoqi , Wang Jiahao , Fu Zhongyou , Dai Guiming , Tang Yu , Chu Fei , Hou Ting , Wang Yiyin , Song Ye 
Published: February 2025

AbstractVarious functional modifications of anodic TiO2 nanotubes (ATNTs) have been widely studied, but the control of porosity of ATNTs is the key to depositing nanofunctional materials into the tubes. It is difficult to obtain ATNTs with a high porosity in a short anodizing process. The morphologies of ATNTs obtained by one‐step anodization and two‐step anodization were compared in this work. In the process of one‐step anodization at 50 V for 30 min, the surface covering layer on the surface of the obtained ATNTs could reduce the porosity of the nanotube arrays (only 4.58%). However, the titanium substrate, with concaves left after the first step anodization in the electrolyte containing polyethylene glycol (PEG600), was once again anodized at 50 V for only 10 min, and the porosity of the formed ATNTs was increased to 21.50%.
Click Chemistry‐Based Bioconjugation of Iron Oxide Nanoparticles
Authors: Asad Shno , Ahl David , Suárez‐López Yael del Carmen , Erdélyi Máté , Phillipson Mia , Teleki Alexandra 
Published: February 2025

AbstractSuperparamagnetic iron oxide nanoparticles (SPIONs) exhibit unique properties for diverse biomedical applications, including drug delivery and diagnostic imaging. Actively targeted SPIONs enhance delivery to diseased sites, reducing side effects and enhancing treatment efficacy. However, the development of reproducible functionalization protocols is challenged by the erratic behavior of nanoparticles in suspensions, such as agglomeration and sedimentation. In this study, a functionalization method is developed and systematically optimized to attach the Fc‐region of antibodies onto silica‐coated SPIONs via click chemistry, ensuring controlled ligand orientation on the particle surface. The synthesis and successive modifications of silica‐coated SPIONs with organic moieties are presented resulting in the final click conjugation with antibodies targeting intercellular adhesion molecule 1 (ICAM1). This protein is upregulated on epithelial cell surfaces during gastrointestinal inflammation. Thermogravimetric analysis and infrared spectroscopy confirm successful SPION functionalization after each modification step. Cell viability assessment indicates no adverse effects of bioconjugated particles. Quantitative elemental analysis reveals significantly higher iron concentration in inflammation‐induced Caco‐2 cells exposed to ICAM1‐modified particles compared to non‐conjugated counterparts. Furthermore, laser scanning confocal microscopy of these cells suggests surface interaction and internalization of bioconjugated SPIONs, underscoring their potential for targeted imaging and therapy in inflammatory diseases.
Ultrasensitive Electrochemical Screening of Circulating Tumor Cells Over Single‐Atom Nanozyme Integrated 3D Nanoarray
Authors: Wu Peilin , Li Yi , He Xun , Fan Jiwen , Li Shuping , Zhang Limei , Tai Yunze , Wei Bin , Luo Han , Yao Yongchao , Wu Min , Yan Lin , Luo Fengming , Ying Binwu , Li Zhengchi , Sun Xuping , Chen Jie 
Published: February 2025

AbstractLate‐stage diagnosis is a major contributor to cancer mortality and thus leads to increased fatality, making early detection crucial for improving survival rates. Circulating tumor cells (CTC), detectable before primary tumors become clinically apparent, have emerged as vital biomarkers for the early identification of aggressive cancers. Here, develop a single‐atom nanozyme integrated nanoarray as a 3D nano‐biointerface for ultrasensitive electrochemical screening of CTCs from hepatocellular carcinoma. This cytosensor is capable of identifying CTC at a single‐cell level, achieving an impressive area under the curve of 0.96 in receiver operating characteristics, comparable to simulated multi‐indicator diagnostic strategies. This screening strategy shows great potential for the non‐invasive early detection of hepatocellular carcinoma and is promising to be applied universally to early cancer diagnosis.
Organic Molecular Amino Acids Additives Containing Amide Groups for Uniform Zinc Deposition in Aqueous Zinc Ion Batteries
Authors: Niu Bo , Zhu Chen , Yuan Haiyang , Xu Wence , Liang Yanqin , Li Zhaoyang , Jiang Hui , Cui Zhenduo , Gao Zhonghui , Zhu Shengli 
Published: February 2025

AbstractAqueous Zn‐metal batteries have been considered as a potentially sustainable energy storage device. They often suffer from poor reversibility and cyclability due to metallic Zn dendrites and parasitic reactions. However, the previous perspectives and mechanisms, coupled with their intricate functional groups for dendrite growth, H2 evolution, and Zn metal corrosion, render the selection criteria of electrolyte additives inherently ambiguous. Herein, it takes amino acids as an example and detailed explored the impact of three typical groups ─NH2, ─COOH, and ─CO─NH2. It is identified that the primary determinant of amide groups can be used as active sites to refine the Zn2+ ion solvation structure and promote Zn deposition. At the Zn metal‐electrolyte interface, the chemisorption of amide onto the surface of the Zn anode inhibits hydrogen evolution and facilitates planar deposition of Zn. As a result, the Zn||Zn cell with optimal amino acids with amide group shows remarkable cycling durability under a current density of 10 mA cm−2. When combined with the NH4V4O10 cathode, the assembled coin cell retains ≈60% of its capacity after 500 cycles. This amino acids molecule additive, emphasize the role of amide group in fine‐tuning Zn2+ solvation structures and Zn/electrolyte interface electrochemical properties.