bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of Mushroom for Removing Wastewater Turbidity: Characterization and Optimization Study
Authors: Tayeb Aghareed M. , Othman Reham H. , Mahmoud Mohamed A. , Monazei Aliaa M. 
Published: June 2024

Abstract

In the present study, a commercially available mushroom is used as a natural flocculent at different dosages to treat a synthetic suspension containing different concentrations of local clay. Response Surface Methodology (RSM) is used to optimize the values of operating parameters based on residual turbidity and turbidity removal percentage reduction. The highest percent reduction in water turbidity was obtained at a pH of 6.7. The lowest value for residual turbidity (11.1 NTU) is achieved by a clay suspension with a concentration of 1000 ppm, and the highest value for residual turbidity (22 NTU) is achieved by a clay suspension with a concentration of 6000 ppm. The optimum values of mushroom dose were 0.2 and 0.1 g for clay concentrations of 4000 and 5000 ppm, respectively, after a time of 120 minutes of settling. Response Surface Methodology (RSM) is used to optimize the values of the operating parameters and the results of the model fitted well with the experimental results.
Measurement-Based Care Implementation by K-12 Public School Clinicians: A Mixed Methods Proof of Concept Study
Authors: Connors Elizabeth , Selino Sophia , Almiral Daniel , Fusco Nicolina , Tebes Jacob 
Published: June 2024

Abstract

Background This study assessed feasibility and acceptability of a multilevel, multi-component implementation strategy for Measurement Based Care (MBC) called Feedback and Outcomes for Clinically Useful Student Services (FOCUSS). FOCUSS includes six components selected in our prior work with a national sample of school mental health stakeholders. This is among the first demonstrations of MBC with school-employed clinicians. We explored proof of concept by observing adoption rates achieved by the end of the school year and other related implementation outcome data. Methods A mixed-method, single-arm pilot study was conducted during one academic year with 10 school-employed mental health clinicians in two K-12 public school districts in Connecticut. Clinician adoption was assessed by monthly fidelity monitoring of measures entered in the feedback system. Clinician self-reported practices, attitudes, feasibility, acceptability and appropriateness of using MBC with K-12 students was assessed by pre-training, 3-, 6- and 9-month surveys. School year-end qualitative interviews explored clinician implementation experiences using MBC and FOCUSS implementation supports to inform future changes to FOCUSS in a district-wide trial. Results Clinicians were asked to implement MBC with five students; 60% of the clinicians achieved or exceeded this target and MBC was adopted with 65 students. Other implementation outcomes were comparable to related studies, and qualitative feedback indicated that MBC is clinically valuable in schools by providing consistency and structure to sessions, is compatible with school mental health and well-regarded by students and parents. FOCUSS implementation supports were regarded as helpful and individual performance feedback emails appeared to be a necessary component of FOCUSS to boost implementation. Conclusion This is among the first studies of MBC implementation with school-employed mental health professionals in the United States. Results demonstrate proof of concept for MBC implementation with school-employed clinicians and support subsequent district-wide use of FOCUSS to install MBC in schools.
Unveiling Novel HIV-1 Protease Inhibitors through an Integrated Analysis of 3D-QSAR, Molecular Docking, and Binding Free Energy
Authors: Zhou Guozheng , Shi Yujie , Li Yan 
Published: June 2024

Introduction:
HIV-1, the primary causative agent of AIDS, remains a formidable and
lethal virus globally, claiming the lives of millions over the past four decades since its discovery.
Recent research has underscored the potential of HIV-1 protease as a therapeutic target, offering a
promising strategy for inhibiting viral replication within the body.

Methods:
In light of this, we have curated an extensive database comprising 193 derivatives of Darunavir
(DRV), an HIV-1 protease inhibitor. Simultaneously, we have developed a comprehensive
set of 3D-QSAR models to elucidate the structure-activity relationships of these 193 derivative inhibitors.
Employing various computational simulation techniques, including Comparative Molecular
Field Analysis (CoMFA), Comparative Similarity Indices Analysis (CoMSIA), and molecular docking,
we have unveiled the fundamental three-dimensional structural features influencing their biological
activity.

Results:
Results indicate that the optimal CoMSIA model (Q2 = 0.500, R2
ncv = 0.882, R2
pred = 0.797)
surpasses other models, demonstrating superior predictive capability. Furthermore, docking results
suggest that DRV derivatives maintain stable conformations within the binding cavity due to synergistic
interactions, such as hydrogen bonding and non-bonded interactions. Drawing insights from
the best computational models, we have designed five DRV derivatives with significant HIV-1 protease
inhibitory activity through local modification, with theoretical calculations indicating favorable
pharmacokinetic properties and synthetic feasibility for the newly proposed molecules.

Conclusion:
It is hoped that the findings and conclusions obtained herein may furnish theoretical
underpinning and directional guidance for the design, optimization, and experimental synthesis of
DRV derivative compounds for pharmaceutical purposes.
A Comprehensive Review of Food Recommendation Systems in the Context of Nutritional Therapy for Diabetes Mellitus
Authors: Prabakaran N. , Rajan Nitya , Chagalasetty Sreelasya , Kakani Vijay 
Published: June 2024

:
Food recommendation systems (FRS) have gained prominence for providing personalized
dietary recommendations. This paper explores the integration of FRS and nutritional
therapy to enhance the management of diabetes mellitus. Nutritional therapy plays a crucial
role in controlling blood glucose levels and reducing complications in diabetes. The study reviews
and analyzes various food recommendation models in diverse scenarios of diabetic nutritional
therapy. By considering specific needs and constraints, the strengths of each model are
assessed, leading to the identification of the most suitable model for each scenario. The findings
contribute to improving the quality of dietary guidance for individuals with diabetes.
Prevalence Estimate for Adjustment Disorders in the South African Navy
Authors: Van Wijk Charles H. 
Published: June 2024

Introduction and Aim
Adjustment Disorder is among the most commonly diagnosed mental disorders in the armed forces, with a mean prevalence estimated at 7.4% across military populations. The prevalence in South African military populations is not known. This study aimed to estimate the prevalence of Adjustment Disorders in the South African Navy and to explore potential risk factors.

Methods
In this cross-sectional study, a representative sample of 714 sailors completed the International Adjustment Disorder Questionnaire, and also provided information from their biennial occupational health assessment mental health screening, which included other clinical screeners of mental health and adjustment history.

Results
The estimated prevalence of Adjustment Disorders in the South African Navy was 6.9%, and was proportionally distributed across gender and age categories. Depression and PTSD were the main comorbid conditions. Risk factors included a) history of adjustment difficulties during military deployment or family adjustment difficulties, b) domestic discord (difficulties in relationship with spouse/partner or immediate family), and c) the experience of stress overload (i.e., that the demands of life are overwhelming available resources).

Conclusion
The estimated prevalence was similar to the expectation of military personnel generally, although the self-report data needs to be interpreted cautiously. The contributing risk factors offer possible direction for targeted intervention, e.g., skills training and relationship counselling to enhance coping with military service and family challenges, and cognitive behaviour therapy generally to address sailors’ experience of stress overload.
Physico-chemical and Biological Investigations of Ocimum Basilicum L. Cultivated in Algeria
Authors: Merzouki Soraya , Boukeria Sabah , Louafi Fadila , Alma Mohemet Hakki , Erenler Ramazan , Yildiz Ilyes , Boulkroune Mina , Mouats Chabane 
Published: June 2024

Introduction:
This study aims to explore biologically active substances from natural
sources, such as the Ocimum basilicum L. plant, for potential medicines.

Methods:
The LC-MS/MS analysis reveals that the majority of compounds in the aerial portion of
this plant have Hesperidin and Vanillic acid, which are used in treating blood vessel fragility and
neurological diseases like Alzheimer's and Parkinson's. The study conducted a qualitative phytochemical
screening of the hydromethanolic plant extract, revealing different secondary metabolites.
Quantitative studies were conducted to determine the quantities of polyphenols, flavonoids, tannins,
and alkaloids in the extract.

Results:
Our investigations also assessed the antioxidant activity of the hydromethanolic plant extract
using DPPH-free radical scavenging and cyclic voltammetry, providing insights into its potential
to combat oxidative stress.

Conclusion:
Finally, the anticoagulant activity of the hydromethanolic plant extract was examined
through Quick and Cephaline Kaolin time coagulation exploration tests, providing insights into its
impact on coagulation pathways.
Ionic Liquids as an Efficient Reaction Medium in the Robust Synthesis of
ZnO Nanoparticles
Authors: Bhirud Sangita R. , Sarode Chandrakant H. , Gupta Gaurav R. , Chaudhari Ganesh R. 
Published: June 2024

Aim::
Ionic liquids belong to the class of green solvents and are distinguished by their
simple yet distinctive physical properties that are related to their structure. These properties include
their remarkable thermal stability, exceptional thermal conductivity, and negligible vapor pressure.
Additionally, they are suitable and inert for a wide range of catalytic applications. Zinc Oxide Nanoparticles
(ZnO-NPs) have been considered a cost-effective choice that requires modest reaction
conditions to provide a high yield of the required products with remarkable selectivity in a short
amount of time. Consequently, an investigation into the synthesis of ZnO-NPs in an ionic liquid
medium has been attempted in the current work.

Background::
The synthesis of metal nanoparticles using highly tunable ionic liquids is being investigated
for many pharmacological applications and their usage in catalysis.

Objectives::
In this context, the current work has used the co-precipitation approach to synthesize
ZnO-NPs. The production of ZnO nanoparticles with a range of morphologies utilizing an imidazolium
ionic liquid system has been the main topic of discussion.

Methods::
The co-precipitation method has successfully been administered for the synthesis of morphologically
diverse nano-crystalline ZnO particles using different ionic liquids, such as 1-propyl-
3-methylimidazolium bromide (pmim)(Br), 1-butyl-3-methylimidazolium bromide ([bmim][Br]),
and 1-hexyl-3-methylimidazolium bromide (hmim)(Br) as an additive

Results::
Modern analytical tools, including X-ray Diffraction (XRD), Scanning Electron Microscopy
(SEM), and FT-IR absorption spectroscopy have been employed to confirm the structure of
these ZnO nanoparticles. The IR absorption peak below 480 cm-1 and the XRD pattern showed all
the peaks in the diffraction diagram, revealing the formation of ZnO-NPs. FE-SEM images showed
various morphologies of ZnO-NPs and they have been found to be separated from the agglomerated
clusters.

Conclusion::
The characteristic results have revealed ionic liquids to have substantial effects on the
size of the zinc nano-species as well as provide the appropriate environment for the growth of the
nanoparticles.
Synthesis of Form-stable Phase Change Materials for Application in Lunch Box to Keep the Food Warm
Authors: Agrawal Nidhi , Arora Bharti 
Published: June 2024

Introduction:
The invention of a lunch box with phase-change materials
incorporated to keep food warm throughout work hours is the subject of this paper.
Since harmful chemicals render the food unfit for consumption when they come into
contact with it, the choice of phase change material is essential.

Method:
Adopting a healthy lifestyle now includes carrying electronic lunch boxes
and ordering takeaways. Nevertheless, utilizing the electric lunch box at work is a
bother. Therefore, this study discusses a prototype of a lunch box that has been created
and can keep food warm after it has been packed at home for 4-5 hours. The
method of preparing the PCM FS65 is discussed and its stability over thermal cycling
is analyzed.

objective:
To synthesize phase change material composite which does not go into liquid state in melting cycle.
To understand the thermal stability of the phase change material composite
To prove the efficacy of the composite in lunch box for keeping the food warm

Result:
The thermal resistance of the insulating materials and the quantity of PCM are
the two design considerations for the lunch box that have been covered in this study.
To explore these, a warm food criterion at a temperature of 45°C has been used.

Conclusion:
This research article has discussed the ideal PCM weight required for a
5-hour retention time as well as the ideal insulating material to make the least bulky
lunch box design.
Comparing Human-Smartphone Interactions and Actigraphy Measurements for Circadian Rhythm Stability and Adiposity: Algorithm Development and Validation Study
Authors: Chuang Hai-Hua , Lin Chen , Lee Li-Ang , Chang Hsiang-Chih , She Guan-Jie , Lin Yu-Hsuan 
Published: June 2024

Background
This study aimed to investigate the relationships between adiposity and circadian rhythm and compare the measurement of circadian rhythm using both actigraphy and a smartphone app that tracks human-smartphone interactions.

Objective
We hypothesized that the app-based measurement may provide more comprehensive information, including light-sensitive melatonin secretion and social rhythm, and have stronger correlations with adiposity indicators.

Methods
We enrolled a total of 78 participants (mean age 41.5, SD 9.9 years; 46/78, 59% women) from both an obesity outpatient clinic and a workplace health promotion program. All participants (n=29 with obesity, n=16 overweight, and n=33 controls) were required to wear a wrist actigraphy device and install the Rhythm app for a minimum of 4 weeks, contributing to a total of 2182 person-days of data collection. The Rhythm app estimates sleep and circadian rhythm indicators by tracking human-smartphone interactions, which correspond to actigraphy. We examined the correlations between adiposity indices and sleep and circadian rhythm indicators, including sleep time, chronotype, and regularity of circadian rhythm, while controlling for physical activity level, age, and gender.

Results
Sleep onset and wake time measurements did not differ significantly between the app and actigraphy; however, wake after sleep onset was longer (13.5, SD 19.5 minutes) with the app, resulting in a longer actigraphy-measured total sleep time (TST) of 20.2 (SD 66.7) minutes. The obesity group had a significantly longer TST with both methods. App-measured circadian rhythm indicators were significantly lower than their actigraphy-measured counterparts. The obesity group had significantly lower interdaily stability (IS) than the control group with both methods. The multivariable-adjusted model revealed a negative correlation between BMI and app-measured IS (P=.007). Body fat percentage (BF%) and visceral adipose tissue area (VAT) showed significant correlations with both app-measured IS and actigraphy-measured IS. The app-measured midpoint of sleep showed a positive correlation with both BF% and VAT. Actigraphy-measured TST exhibited a positive correlation with BMI, VAT, and BF%, while no significant correlation was found between app-measured TST and either BMI, VAT, or BF%.

Conclusions
Our findings suggest that IS is strongly correlated with various adiposity indicators. Further exploration of the role of circadian rhythm, particularly measured through human-smartphone interactions, in obesity prevention could be warranted.
Impact of Responsible AI on the Occurrence and Resolution of Ethical Issues: Protocol for a Scoping Review
Authors: Boege Selina , Milne-Ives Madison , Meinert Edward 
Published: June 2024

Background
Responsible artificial intelligence (RAI) emphasizes the use of ethical frameworks implementing accountability, responsibility, and transparency to address concerns in the deployment and use of artificial intelligence (AI) technologies, including privacy, autonomy, self-determination, bias, and transparency. Standards are under development to guide the support and implementation of AI given these considerations.

Objective
The purpose of this review is to provide an overview of current research evidence and knowledge gaps regarding the implementation of RAI principles and the occurrence and resolution of ethical issues within AI systems.

Methods
A scoping review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines was proposed. PubMed, ERIC, Scopus, IEEE Xplore, EBSCO, Web of Science, ACM Digital Library, and ProQuest (Arts and Humanities) will be systematically searched for articles published since 2013 that examine RAI principles and ethical concerns within AI. Eligibility assessment will be conducted independently and coded data will be analyzed along themes and stratified across discipline-specific literature.

Results
The results will be included in the full scoping review, which is expected to start in June 2024 and completed for the submission of publication by the end of 2024.

Conclusions
This scoping review will summarize the state of evidence and provide an overview of its impact, as well as strengths, weaknesses, and gaps in research implementing RAI principles. The review may also reveal discipline-specific concerns, priorities, and proposed solutions to the concerns. It will thereby identify priority areas that should be the focus of future regulatory options available, connecting theoretical aspects of ethical requirements for principles with practical solutions.

International Registered Report Identifier (IRRID)
PRR1-10.2196/52349
Pengaruh grind size dan tipe portafilter terhadap kualitas espresso pada mesin espresso sistem pneumatik
Authors: Winarso Rochmad , Khoeron Slamet , Wibowo Rianto , Darmanto Darmanto 
Published: June 2024

Penelitian ini bertujuan untuk mengetahui pengaruh temperature, grind size dan jenis portafilter terhadap kadar total dissolved solids (TDS) dan extraction yield (EXT) dan menemukan pengaturan mesin kopi espresso sistem pneumatik yang optimal untuk mencapai kualitas terbaik. Pada penelitian ini dilaksanakan dengan menguji karakteristik kopi espresso yaitu kadar total dissolve solid (TDS) dan extraction yield (EXT) akibat pengaruh temperatur, grind size dan tipe portafilter. Desain eksperimen faktorial penuh (full factorial design of experiments - FFD) digunakan untuk mengidentifikasi variabel yang memiliki pengaruh yang signifikan pada kualitas espresso yang dihasilkan. Data penelitian diolah menggunakan analisa varian (analysis of variance - ANOVA) dengan bantuan perangkat lunak Minitab. Hasil penelitian menunjukkan bahwa temperature, grind size dan tipe portafilter secara statistik memiliki pengaruh yang signifikan dengan tingkat kepercayaan 100% dalam mempengaruhi kadar total dissolved solids (TDS). Grind size dan tipe portafilter secara statistik juga memiliki pengaruh signifikan terhadap extraction yield (EXT) dengan tingkat kepercayaan 100%. Sebaliknya, nilai p-value yang lebih tinggi untuk faktor temperatur menunjukkan bahwa faktor tersebut secara statistik tidak memiliki pengaruh signifikan terhadap extraction yield (EXT). Hasil optimasi respons untuk kadar total dissolved solids (TDS) dan extraction yield (EXT) menghasilkan niai composite desirability (D) sebesar 0,7255. Dari nilai tersebut dapat disimpulkan bahwa kondisi optimal yang ditemukan melalui plot optimasi cukup dapat diandalkan dan sesuai dengan model regresi yang telah diuji secara kredibel. Variabel yang dapat menghasilkan kadar total dissolved solids (TDS) dan extraction yield (EXT) paling optimal didapat dari pengaturan temperatur 1000C, grind size 2.8 dan penggunaan un-pressurized portafilter. Kadar total dissolved solids (TDS) dan extraction yield (EXT) yang dihasilkan dari metode respon optimasi ini masing-masing sebesar 11,5252% dan 22,348%.
Analisis Kegagalan Mesin Produksi Rokok Cigarillos dengan Metode FMEA
Authors: Hutama Adhi Setya , Nugroho Th. Adi , Kurniawan Perwita , Aji Bayu Crisna , Nuriyah Sinta 
Published: June 2024

Industri Hasil Tembakau menjadi salah satu sektor manufaktur nasional yang strategis, berkontribusi besar dan berdampak luas terhadap pembangunan bangsa. Salah satu industri yang bergerak dibidang pengolahan hasil tembakau adalah PT. XYZ, dengan produknya adalah rokok cigarillos. Mesin produksi pada produk ini terdiri dari gluing dan cutting. Hasil wawancara yang dilakukan peneliti selama bulan agustus – oktober 2022 ditemukan adanya cacat produk berupa seperti broken (873 pcs) dan wrapper loose parah (14.521), dengan total prosentase rata rata 30%, melebihi standar yang ditetapkan perusahaan (15%). Hal ini imbas dari kondisi mesin yang tidak terawat (roll finger dan vacuum roll kotor menyebabkan wrapper loose, dan bunker yang bermasalah menyebabkan rokok patah). Metode Failure Mode and Effect Analysis (FMEA) digunakan dalam studi ini untuk mengidentifikasi risiko kegagalan, mendapatkan nilai Risk Priority Number (RPN) dan memberikan usulan perbaikan untuk produksi selanjutnya. Studi ini berhasil menemukan penyebab kegagalan produksi yaitu roller tidak bersinggungan dengan belt (Nilai RPN adalah 45). Rekomendasi yang diberikan kepada perusahaan adalah modifikasi dudukan roll belt dengan memperbesar radius atas pada dudukan belt.
Pengaruh Variasi Waktu Penembakan pada Proses Shot Peening terhadap Sifat Mekanis Baja ST 60
Authors: Warso Warso , Supriyana Nana , Sutarno Sutarno 
Published: June 2024

Baja ST 60 banyak digunakan pada komponen permesinan, roda gigi, poros, konstruksi bangunan dan lain sebagainya. Beberapa perlakuan untuk merubah sifat mekanik yang diperlukan salah satunya menggunakan metode shot peening. Penelitian ini bertujuan untuk menganalisa sifat kekerasan permukaan pada baja ST 60 setelah diproses shot peening dengan variasi waktu 5,10,20,30 dan 40 menit, material shot peening menggunakan ball steel diameter 0,8 mm, tekanan udara 7 kg/cm², dan jarak tembak antara nozzle dengan permukaan benda uji 10 cm. kemudian diuji kekerasan permukaan. Hasil penelitian menunjukan variasi waktu shot peening durasi 10 menit mendapatkan nilai kekerasan sebesar 286,2 VHN. Proses shot peening dengan durasi10 menit menghasilkan kekasaran sebesar 3,74 µm. Hasil uji struktur mikro juga mengalami perubahan ditandai dengan fasa perlit senilai 61,5 %, fasa ferit senilai 38,4 %, Pengujian SEM pada spesimen dengan durasi 10 menit menunjukan adanya dimple fracture yang kecil, memperlihatkan adanya perubahan sifat mekanis Baja ST 60.