bluuebunny/crossref_metadata_2025_split huggingface dataset:
Awareness, treatment, and control of hypertension among women at risk or living with HIV in the US South
Authors: Blair Jessica , Kempf Mirjam-Colette , Dionne Jodie A. , Causey-Pruitt Zenoria , Wise Jenni M. , Jackson Elizabeth A. , Muntner Paul , Hanna David B. , Kizer Jorge R. , Fischl Margaret A. , Ofotokun Igho , Ramirez Catalina , Gange Stephen J. , Brill Ilene K. , Levitan Emily B. 
Published: June 2024

Objectives:
Timely control of hypertension is vital to prevent comorbidities. We evaluated the association of race/ethnicity and HIV infection with incident hypertension outcomes, including awareness, treatment, and control.

Design:
We evaluated cisgender women living with HIV and sociodemographically matched women living without HIV recruited into four Southern sites of the Women's Interagency HIV Study (WIHS) (2013–2019).

Methods:
We calculated measurements of the time to four events or censoring: incident hypertension, hypertension awareness, hypertension treatment, and hypertension control. Hazard ratios for race/ethnicity and HIV status were calculated for each outcome using Cox proportional-hazards models adjusted for sociodemographic, behavioral, and clinical risk factors.

Results:
Among 712 women, 56% were hypertensive at baseline. Forty-five percentage of the remaining women who were normotensive at baseline developed incident hypertension during follow-up. Non-Hispanic white and Hispanic women had faster time to hypertension control compared with non-Hispanic black women (P = 0.01). In fully adjusted models, women living with HIV who were normotensive at baseline had faster time to treatment compared with normotensive women living without HIV (P = 0.04).

Conclusion:
In our study of women in the US South, non-Hispanic black women became aware of their hypertension diagnosis more quickly than non-Hispanic white and Hispanic women but were slower to control their hypertension. Additionally, women living with HIV more quickly treated and controlled their hypertension compared with women living without HIV.
ACTIVATION OF KLOTHO/SIRT1 SIGNALING PATHWAY ATTENUATES MYOCARDIAL ISCHEMIA REPERFUSION INJURY IN DIABETIC RATS
Authors: Qiu Zhen , Qi Biao , Li Lu , Cui Jiahui , Liu Min , Xia Zhongyuan 
Published: June 2024

ABSTRACT
Diabetes and myocardial ischemia reperfusion (MIR) injury are characterized by oxidative stress, inflammation, autophagy disorders, and cardiac contractile dysfunction. Klotho and SIRT1 regulate the level of oxidative stress to participate in the regulation of many physiological functions such as cell survival, aging, apoptosis, autophagy, mitochondrial biogenesis, and inflammation. We hypothesized that the activation of Klotho/SIRT1 signaling pathway could attenuate MIR in diabetic rats. Type 1 diabetes and MIR injury model were established to examine this hypothesis in vivo. Primary rat cardiomyocytes and H9c2 cells were exposed to high glucose conditions and hypoxia/reoxygenation (H/R) insult in vitro. Hemodynamic parameters of heart function, myocardial infarct size, oxidative stress, markers of MIR injury or cell viability, and the mRNA and protein expression of Klotho and SIRT1 were measured. There was lower expression of Klotho and SIRT1 in diabetic MIR hearts than in nondiabetic rats, as well as significantly increased oxidative stress levels and decreased autophagy levels. Recombinant Klotho (rKlotho) protein and the SIRT1 agonist SRT1720 could significantly attenuate MIR injury in diabetes by activating Klotho/SIRT1 signaling pathway to reduce oxidative stress and restore autophagy levels. These findings suggest that the Klotho/SIRT1 pathway plays an important role in MIR injury in diabetic rats, and rKlotho protein and agonist SRT1720 have therapeutic potential for alleviating diabetic myocardial IR injury by activating Klotho/SIRT1 to reduce oxidative stress and restore autophagy levels.
Sex-based Disparities in Liver Transplantation for Hepatocellular Carcinoma and the Impact of the Growing Burden of NASH
Authors: Koh Jia Hong , Chee Douglas , Ng Cheng Han , Wijarnpreecha Karn , Muthiah Mark , Tan Darren Jun Hao , Lim Wen Hui , Zeng Rebecca Wenling , Koh Benjamin , Xuan Eunice Tan Xiang , Bonney Glenn , Iyer Shridhar , Young Dan Yock , Nakamura Toru , Takahashi Hirokazu , Noureddin Mazen , Siddiqui Mohammad Shadab , Simon Tracey G. , Loomba Rohit , Huang Daniel Q. 
Published: June 2024

Background.
The cause of liver disease is changing, but its impact on liver transplantation (LT) for hepatocellular carcinoma (HCC) in women and men is unclear. We performed a nationwide study to assess the prevalence and posttransplant survival outcomes of the various causes of liver disease in women and men with HCC.

Methods.
Data were obtained from the United Network for Organ Sharing database from 2000 to 2022. Data related to the listing, transplant, waitlist mortality, and posttransplant mortality for HCC were extracted. The proportion of HCC related to the various causes of liver disease among LT candidates and recipients and posttransplant survival were compared between women and men.

Results.
A total of 51 721 individuals (39 465 men, 12 256 women) with HCC were included. From 2000 to 2022, nonalcoholic steatohepatitis (NASH) was the fastest-growing cause of liver disease among female LT candidates with HCC (P < 0.01), followed by alcohol-associated liver disease. NASH overtook chronic hepatitis C as the leading cause of liver disease in 2020 and 2022 among waitlisted women and men with HCC, respectively. Female patients with HCC spent a significantly longer time on the LT waitlist compared with male patients (β: 8.73; 95% confidence interval [CI], 2.91-14.54). Female patients with HCC from alcohol-associated liver disease also have a lower probability of receiving LT (subdistribution hazard ratio: 0.90; 95% CI, 0.82-0.99). Among transplant recipients with NASH HCC, female sex was associated with lower posttransplant mortality compared with male sex (hazard ratio: 0.79; 95% CI, 0.70-0.89; P < 0.01).

Conclusions.
Women have a significantly longer waitlist duration compared with men. NASH is now the leading cause of liver disease among both female and male LT candidates and recipients with HCC.
Shared genetic architecture and causal pathways between attention deficit hyperactivity disorder and restless legs syndrome
Authors: Li Fu-Jia , Li Jin-Yu , Zhang Ru-Yu , Liu Xuan-Jing , Lv Bing-Chen , Zhang Tao , Liu Yu-Ning , Zhang Zi-Xuan , Zhang Wei , Cui Gui-Yun , Xu Chuan-Ying 
Published: June 2024

AbstractPrevious studies have revealed a significant overlap between ADHD and RLS populations, with shared pathological mechanisms such as dopaminergic function and iron metabolism deficits. However, the genetic mechanisms underlying these connections remain unclear. In our study, we conducted a genome-wide genetic correlation analysis to confirm a shared genetic structure between ADHD and RLS. We identified five pleiotropic loci through PLACO analysis, with colocalization analysis revealing a shared causal genetic variant, rs12336113, located in an intron of the PTPRD gene within one of these loci. Additionally, we identified 14 potential shared genes and biological pathways between these diseases. Protein-protein interaction analysis demonstrated close interactions among six genes: PTPRD, MEIS1, MAP2K5, SKOR1, BTBD9, and TOX3. We further investigated gene-driven causal pathways using univariable Mendelian randomization (MR), multivariable MR, and Network MR analyses. Our findings indicate that ADHD may indirectly promote the onset of RLS by advancing the age of first birth, while RLS could indirectly contribute to ADHD by reducing fractional anisotropy in body of corpus callosum. Notably, an increase in radial diffusivity, rather than a decrease in axial diffusivity, played a crucial role in this process. In conclusion, our research supports a close genetic link between ADHD and RLS, identifying PTPRD as the most likely pleiotropic gene between these conditions. Moreover, ADHD may indirectly promote RLS onset by advancing the age of first birth, while RLS may indirectly promote ADHD onset by causing demyelination in body of corpus callosum.
Incorporating face-to-face and online learning features to propose blended learning framework for Post-COVID classrooms in India
Authors: Qamar Md. Tauseef , Malik Abdullah , Yasmeen Juhi , Sadiqe Mohd. , Ajmal Mohd 
Published: June 2024

PurposeThis study examines learner readiness and satisfaction with blended learning systems in India’s post-vaccine classrooms, focusing on the relationship between face-to-face (F2F), online learning (OL), and blended learning (BL) indicators and identifying which predictors within these systems most significantly affect learners’ satisfaction (LS).Design/methodology/approachAn online survey was conducted with 451 students from both public and private universities in India. The data were analyzed using factor analysis and confirmatory factor analysis, followed by multiple regression to test the hypotheses.FindingsThe findings reveal a significant positive correlation between learners’ satisfaction and online learning and blended learning, with β values of 28.3 and 27.2, bearing a p-value of 0.000. In contrast, face-to-face (F2F) learning was insignificant, with a β value of 0.070 and a p-value of 0.119. These insights underscore the effectiveness of online and blended learning formats in enhancing learner satisfaction in higher education while also suggesting a re-evaluation of the role of traditional F2F learning methods. The research supports the integration of online learning in higher education due to its balanced mix of teacher-led and student-centered instruction, alongside the practical benefits of reduced travel costs and access to independent study resources.Practical implicationsThis study provides insights into student perceptions and attitudes towards blended learning in India’s post-vaccine classrooms. It highlights the importance of tailoring blended learning strategies to meet colleges’ and universities’ diverse learning needs and goals in this evolving context. The findings serve as a valuable resource for educators and administrators, aiding in designing effective blended learning frameworks suited explicitly for higher education in India.Originality/valueWhile there is extensive literature on F2F, OL, and BL, limited research compares these learning approaches and their impact on learner satisfaction within the Indian higher education context. This study fills this gap by providing valuable insights for shaping educational strategies in India’s post-vaccine classrooms.
Tweeting for office: decoding digital relevance in Spanish general elections 2011–2023
Authors: Alonso-Magdaleno María Isabel , García-García Jesús 
Published: June 2024

PurposeThe paper analyses the role and impact of Twitter in Spanish political communication, specifically focusing on how the platform influences the visibility and relevance of political candidates' messages during various election campaigns and across various political dimensions – government vs. opposition, traditional vs. populist, and left-wing vs. right-wing.Design/methodology/approachThe study employs a longitudinal quantitative analysis perspective regarding the number and impact of messages posted by the main candidates in the six general elections held in Spain during the period 2011–2023. The tweets were automatically collected through the Twitter API for 54 days, between the call for elections and voting. The equalisation versus normalisation framework regarding social media is used.FindingsThe findings showed that the dissemination of messages on Twitter exhibited a skewed distribution characterized by notable differences in the unequal relevance of tweets between candidates on the left-right and traditional-populist axes, especially among the tweets with the highest impact. Tweets from opposition and populist candidates presented a greater level of relevance than those from government and conventional candidates. No discernible differences were identified along the ideological spectrum, indicating a high degree of cross-partisan engagement on social media. Findings indicate that opposition and populist candidates are strategically utilising Twitter, challenging the notion of normalisation and emphasising the equalising potential of social networks.Originality/valueThe study offers a long-term view of political communication, which is relatively rare in social media research, often focused on shorter time frames or single election cycles. The multidimensional comparison provides nuanced insights into how different political identities and affiliations are manifested and engaged with on social media.
Keeping pace with competitors in CSR: from a perspective of competitive dynamics
Authors: Zou Hailiang , Yang Xiyuan , Wang Ruijing 
Published: June 2024

Purpose
This study aims to investigate the antecedents of corporate social responsibility (CSR) from the perspective of competitive dynamics and proposes a correlation of CSR between competing firms because rival firms’ engagement in CSR induces the focal firm’s catch-up to keep pace with them.

Design/methodology/approach
Using a sample of Chinese listed companies through the lens of firm dyads, and drawing on the awareness-motivation-capability (AMC) framework, a set of contingencies of firms’ competitive catch-up in CSR are examined, including the visibility of its competitors, the interdependence between the focal firm and its competitors and the focal firm’s resource slack.

Findings
The empirical results reveal that a focal firm’s CSR is in a positive relationship with that of its competitors, which is strengthened by the visibility of its competitors, the interdependence between the focal firm and its competitors, and is affected by the focal firm’s resource slack.

Originality/value
These findings uncover the interplay of CSR among competitors, enriching our understanding of its antecedents by extending the AMC framework to the CSR context.
Islamic destination to millennials in Bandung: Islamic attributes and destination image on tourist satisfaction with visiting decision as mediator
Authors: Suryawardani Bethani , Wulandari Astri , Marcelino Dandy , Millanyani Heppy 
Published: June 2024

Purpose
The study aims to explore millennial tourist satisfaction in an Islamic tourism destination, which this research will clarify the relationship between Islamic attributes and destination image on visiting decisions and their influence on tourist satisfaction.

Design/methodology/approach
The quantitative research approach with exploratory by applying structural equation model techniques, which method of collection data by surveys. Purposive sampling was used to 400 Muslim millennials tourist who visit Islamic destination in Bandung, Indonesia. The questionnaire used in this study based on a review of previous studies.

Findings
The findings show that a destination’s Islamic attribute has substantial influence on destination image and millennials’ choice to visit the tourist site. Then Islamic attributes have positive influence on millennials’ willingness to visit Bandung as visitors. A strong identification with a location’s destination image has been demonstrated a positive impact on visiting destination. This research revealed that the visiting choice had a favorable and substantial influence on Islamic visitor satisfaction through visiting decision to Bandung.

Research limitations/implications
This research focuses on millennials tourist whoever visit Bandung tourist destination, the research findings may be limited in their generalizability. As a result, researchers are encouraged to explore the offered hypotheses further.

Practical implications
Islamic tourism business players who are targeting the millennial generation as their target market are urged to pay close attention the Islamic attributes and destination image, because according to the research results. These variables have an impact on visiting decisions and tourist satisfaction. Then the online travel agent should maintain the destination image by promoting the destination in offline and online media.

Social implications
The findings of this study are expected to enrich the literature on consumer behavior, especially in the tourism industry in the Tourism 4.0 era.

Originality/value
To the best authors’ knowledge, the research model is never been explore by other researchers in the field of Islamic tourism literatures. For further studies, the authors’ can modify this research by using different objects so that comparisons can be made and using other determinant factors that can affect the satisfaction of Muslim tourists.
From phenomenology to items: a mixed method approach to develop a scale of workplace Islamic da’wah
Authors: Liaqat Hajira , Ahmed Ishfaq , Yousaf Sheikh Usman 
Published: June 2024

Purpose
This study aims to develop a Workplace Islamic Da’wah (WID) scale, which measures the extent to which an organization incorporates the sharing of religious teachings at work through words and artifacts. WID is theoretically grounded in religious communication theory and is intended for use in organizational settings.

Design/methodology/approach
A sequential mixed methods approach was used to develop a scale of WID. Qualitative data were organized into constructs and items using transcendental phenomenology. These items were then refined into a multidimensional construct through expert validity, face validity, exploratory factor analysis and confirmatory factor analysis.

Findings
The research findings confirm the validity and reliability of WID as a multidimensional construct, comprising compulsive da’wah, objectics da’wah and impulsive da’wah.

Research limitations/implications
This study provides implications for survey researchers interested in developing a scale using mixed methods and for practitioners who can use these findings to streamline their efforts in planning and implementing an Islamic da’wah-based model.

Originality/value
To the best of the authors’ knowledge, this study is the first of its kind, presenting the operationalization of WID that can be used for future empirical research endeavors in this and related fields.
A rise in the prominence of business? The political role of corporations in Denmark over two decades
Authors: Binderkrantz Anne S. , Bülow Magnus , Christiansen Peter M. , Helbo Emma 
Published: June 2024

AbstractRecent research has documented a significant and rising presence of corporations in politics. In this letter, we ask to what extent corporations in Denmark have increased their political activity and access to political arenas during the last two decades. The analysis draws on two surveys among large corporations conducted in 2001 and 2022. This allows us to compare the extent to which corporations use tactics such as targeting the news media as well as their reported levels of contact to public authorities. We find that corporations today are engaged in broader questions and use a wider set of strategies than around the turn of the century, but also that their contacts to public administrative authorities have decreased and that a larger share of corporations are only active through collective organisations. This provides an important corrective to the existing image of a uniform rise in the political activities of private corporations.
Comparison between SeHCAT test and clinical response to cholestyramine in patients with chronic diarrhea and high suspicion of bile acid malabsorption: A single‐center prospective study
Authors: Schiepatti Annalisa , Bossert Irene , Cincotta Marta , Zanini Carolina Arianna , Maimaris Stiliano , D'Ambrosio Daniela , Trifirò Giuseppe , Biagi Federico 
Published: June 2024

ObjectivesWe aimed to evaluate the clinical response to cholestyramine in patients with functional chronic diarrhea and a high clinical suspicion of bile‐acid diarrhea (BAD) investigated with 75‐selenium homocholic acid taurine (SeHCAT) test.MethodsAdult patients attending our outpatient clinic between January and December 2021 for chronic diarrhea with suspicion of BAD were proposed SeHCAT testing and a therapeutic trial of cholestyramine 4–8 g daily. Clinical response to cholestyramine was evaluated at 1, 3, 6, and 12 months. Clinical and demographic data were analyzed according to SeHCAT test results.ResultsAmong the 50 patients with chronic diarrhea and clinical suspicion of BAD, 13 (26.0%) refused either SeHCAT testing or cholestyramine therapy. Finally, 37 patients (31 females, age 44 ± 14 years) agreed to undergo SeHCAT and were started on cholestyramine (median follow‐up 14 months [interquartile range 6–16 months]). Initial response to cholestyramine was similar in patients with positive and negative SeHCAT test results, but improved over time in those with a positive test result. Long‐term response (100% vs 65.2%, P = 0.02) and necessity of maintenance therapy for symptom control were more common in those with positive SeHCAT test result (71.4% vs 26.1%, P = 0.02). However, response to cholestyramine was also frequent in patients with a negative test result.ConclusionsThe SeHCAT test accurately identifies patients with BAD who benefit from long‐term cholestyramine treatment. Nevertheless, cholestyramine may be also effective in patients with chronic diarrhea but negative SeHCAT test result.
Elevated Plasma Levels of Arginines During Labor Among Women with Spontaneous Preterm Birth: A Prospective Cohort Study
Authors: Akhter Tansim , Hedeland Mikael , Bergquist Jonas , Ubhayasekera Kumari , Larsson Anders , Byström Ludvig , Kullinger Merit , Skalkidou Alkistis 
Published: June 2024

ABSTRACTProblemPreterm birth (PTB) is a leading cause of infant mortality and morbidity. The pathogenesis of PTB is complex and involves many factors, including socioeconomy, inflammation and infection. Asymmetric dimethylarginine, ADMA and symmetric dimethylarginine, SDMA are involved in labor as inhibitors of nitric oxide, a known relaxant of the uterine smooth muscles. Arginines are scarcely studied in relation to PTB and we aimed to investigate arginines (ADMA, SDMA and L‐arginine) in women with spontaneous PTB and term birth.Methods of the StudyThe study was based on data from the population‐based, prospective cohort BASIC study conducted in Uppsala County, Sweden, between September 2009 and November 2018. Arginines were analyzed by Ultra‐High Performance Liquid Chromatography using plasma samples taken at the onset of labor from women with spontaneous PTB (n = 34) and term birth (n = 45). We also analyzed the inflammation markers CRP, TNF‐R1 and TNF‐R2 and GDF‐15.ResultsWomen with spontaneous PTB had higher plasma levels of ADMA (p < 0.001), and L‐Arginine (p = 0.03). In addition, inflammation marker, TNF‐R1 (p = 0.01) was higher in spontaneous PTB compared to term birth. Further, in spontaneous PTB, no significant correlations could be observed when comparing levels of arginines with inflammation markers, except ADMA versus CRP.ConclusionsThese findings provide novel evidence for the potential involvement of arginines in the pathogenesis of spontaneous PTB and it seems that arginine levels at labor vary independently of several inflammatory markers. Further research is warranted to investigate the potential of arginines as therapeutic targets in the prevention and management of spontaneous PTB.