bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-cell variations of circadian clock and immune gene expression in microglia and neurodegeneration
Authors: Ouk Koliane , Yalçin Müge , Rigat Ludovica , Keren-Shaul Hadas , David Eyal , Knop Anniki , Böttcher Chotima , Kramer Achim , Amit Ido , Relógio Angela , Priller Josef 
Published: June 2024

SummaryWe investigated the diurnal rhythmicity of gene expression in microglia, the resident macrophages of the brain, in health and disease. Using RNA sequencing and single-cell analysis by RNAscope, we examined wild-type mice and the R6/2 transgenic mouse model of Huntington’s disease (HD). Our findings suggest context-dependent rhythmic gene expression in microglia, exhibiting substantial variability between individual cells and brain regions over 24 hours. Notably, we observed loss of rhythmic gene expression of key clock genes in microglia from symptomatic but not presymptomatic R6/2 mice. Moreover, we identifiedde novo24-hour rhythmic gene expression and altered diurnal patterns of immune-related genes associated with neurodegenerative diseases in microglia from symptomatic R6/2 mice. Our findings suggest circadian reprogramming of microglia in the context of neurodegeneration.
The baboon as a statistician: Can non-human primates perform linear regression on a graph?
Authors: Ciccione Lorenzo , Brecht Thomas Dighiero , Claidière Nicolas , Fagot Joël , Dehaene Stanislas 
Published: June 2024

AbstractRecent studies showed that humans, regardless of age, education, and culture, can extract the linear trend of a noisy graph. Here, we examined whether such skills for intuitive statistics are confined to humans or may also exist in non-human primates. We trained Guinea baboons (Papio papio) to associate arbitrary geometrical shapes with the increasing or decreasing trends of noiseless and noisy scatterplots, while varying the number of points, the noise level, and the regression slope. Many baboons successfully learned this conditional match-to-sample task for both noiseless and noisy plots. Crucially, for successful baboons, accuracy varied as a sigmoid function of the t-value of the regression, the same statistical index upon which humans also base their answers, even after controlling for other variables. These results are compatible with the hypothesis that the human perception of data graphics is based on the pre-emption and recycling of a phylogenetically older competence of the primate visual system for extracting the principal axes of visual displays.
A Novel Susceptibility Locus inNFASCHighlights Oligodendrocytes and Myelination in Progressive Supranuclear Palsy Pathology
Authors: García-González Pablo , Lara Héctor Rodrigo , Compta Yaroslau , Fernandez Manuel , van der Lee Sven J. , de Rojas Itziar , Saiz Laura , Painous Celia , Camara Ana , Muñoz Esteban , Marti Maria J. , Valldeoriola Francesc , Puerta Raquel , Illán-Gala Ignacio , Pagonabarraga Javier , Dols-Icardo Oriol , Kulisevsky Jaime , Fortea Juan , Lleó Alberto , Olivé Claudia , de Boer Sterre C.M. , Hulsman Marc , Pijnenburg Yolande A.L. , Belloso Rafael Díaz , Muñoz-Delgado Laura , Rueda Dolores Buiza , Gómez-Garre Pilar , Aldecoa Iban , Aragonés Gemma , Vara Jorge Hernandez , Mendioroz Maite , Pérez-Tur Jordi , Visser Pieter Jelle , den Braber Anouk , Papma Janne M. , Montes Ángel Martín , Rodriguez-Rodriguez Eloy , Blázquez-Folch Josep , Miguel Andrea , García-Gutiérrez Fernando , Cano Amanda , Valero Sergi , Marquié Marta , Capdevila-Bayo María , Rosende-Roca Maitee , Quintela Inés , Carracedo Ángel , Tàrraga Lluís , Real Luis M , Royo Jose Luis , Erro Maria Elena , Guerrero Carmen , Torres Daniela Corte , Blázquez-Estrada Marta , Millán Beatriz San , Teijeira Susana , Rolan Dolores Vilas , Hernández Isabel , Sánchez-Soblechero Antonio , de la Casa-Fages Beatriz , López Soledad Serrano , Baviera-Muñoz Raquel , Lavín Amaya , Taipa Ricardo , Amer Guillermo , Martinez-Saez Elena , Fernández-Matarrubia Marta , Lage-Martínez Carmen , Álvarez Victoria , Molina-Porcel Laura , Holstege Henne , Mir Pablo , Belbin Olivia , Boada Mercè , Fernández Victoria , Bullido María J. , Rábano Alberto , Sánchez-Juan Pascual , Ruiz Agustín 
Published: June 2024

AbstractWe conducted the largest PSP GWAS of the Iberian population to date (522 cases from 22 Spanish and Portuguese institutions). We independently replicated seven known PSP risk variants, and unveiled a novel locus inNFASC/CNTN2after meta-analysing our results with a newly available Dutch cohort and publicly available summary statistics. These findings highlight the importance of neuron-oligodendrocyte interactions in PSP etiopathology.
Cybersecurity, cyber insurance and small-to-medium-sized enterprises: a systematic Review
Authors: Adriko Rodney , Nurse Jason R.C. 
Published: June 2024

Purpose
This study aims to offer insights into the state of research covering cybersecurity, cyber insurance and small- to medium-sized enterprises (SMEs). It examines benefits of insurance to an SME’s security posture, challenges faced, and potential solutions and outstanding research questions.

Design/methodology/approach
Research objectives were formulated, and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocol was used to perform a systematic literature review (SLR). A total of 19 papers were identified from an initial set of 451.

Findings
This research underscores the role of cybersecurity in the value proposition of cyber insurance for SMEs. The findings highlight the benefits that cyber insurance offers SMEs including protection against cyber threats, financial assistance and access to cybersecurity expertise. However, challenges hinder SME’s engagement with insurance, including difficulties in understanding cyber risk, lack of cybersecurity knowledge and complex insurance policies. Researchers recommend solutions, such as risk assessment frameworks and government intervention, to increase cyber insurance uptake/value to SMEs.

Research limitations/implications
There is a need for further research in the risk assessment and cybersecurity practices of SMEs, the influence of government intervention and the effectiveness of insurers in compensating for losses. The findings also encourage innovation to address the unique needs of SMEs. These insights can guide future research and contribute to enhancing cyber insurance adoption.

Originality/value
To the best of the authors’ knowledge, this is the first SLR to comprehensively examine the intersection of cybersecurity and cyber insurance specifically in the context of SMEs.
Analyzing revisitation dynamics: a scholarly analysis of bootstrapping, mediating Muslim-friendly context and impact on determinant factors in Terengganu’s edutourism destinations
Authors: Che Haron Hazrin Izwan , Abdullah Hamdy , Sheikh Ahmad Tajuddin Sheikh Ahmad Faiz , Mohd Zain Fahru Azwa , A. Rahim Nurul Aisyah Awanis 
Published: June 2024

Purpose
This paper aims to investigate the relationships between key mediators, namely, Muslim-friendly context and the intention of tourists to revisit edu-tourism destinations in Terengganu.

Design/methodology/approach
The study engages tourists and visitors who have explored seven distinct edu-tourism destinations, with a total sample size of 384 participants. Data analysis is conducted using the Statistical Package for the Social Sciences and Analysis of Moment Structures for structural equation modeling.

Findings
Findings indicate that Muslim-friendly does not mediate the relationship between tourism operators, events and investment concerning tourists revisiting Terengganu. However, it plays a significant mediating role between local communities, educational institutions and tourism organizations.

Research limitations/implications
Despite valuable insights, limitations arose due to a lack of Terengganu-specific literature on Muslim-friendliness in edu-tourism, leading to reliance on studies about Sharia-compliant hotels, the broader tourism industry and Islamic tourism.

Practical implications
The thriving halal tourism industry’s growth has heightened awareness of Muslim-friendly destinations, like Terengganu. The state actively promotes diverse halal services for Muslim travelers, encouraging operators to prioritize Sharia-compliant facilities. Strategic marketing and government support for Sharia-compliant edu-tourism investments aim at fostering economic growth and ensuring sustainability.

Social implications
Social implications stress the need for inclusivity and cultural sensitivity in Terengganu’s tourism. Prioritizing Muslim-friendly services not only boosts economic growth but also fosters an inclusive and welcoming environment for diverse travelers. Government support for Sharia-compliant edu-tourism investments aligns development with cultural and religious values, promoting a harmonious and inclusive society.

Originality/value
This research explores Terengganu’s innovative edu-tourism approach, prioritizing Muslim-friendly services for diverse travelers. By emphasizing Sharia-compliant facilities and investments, the region aims to foster economic growth and create an inclusive cultural environment.
Everything is in hand: when and why electronic performance monitoring leads to supervisor undermining
Authors: Zhang Qi , Zhou Kong , Shu Peipei , Liu Wenxing , Ouyang Xi , Sun Ao 
Published: June 2024

PurposeThis research aims to address the knowledge gap regarding the influence of electronic performance monitoring (EPM) on supervisors' behavior. Building upon the sociomaterial perspective and the general model of disinhibition, the study explores the internal mechanisms and boundary conditions between supervisor EPM use and supervisor undermining.Design/methodology/approachAn online survey was administered via the Sojump platform, inviting supervisors from diverse industries in China to participate in a three-wave study, each wave being approximately two weeks apart. The study gathered multi-wave data from 225 supervisors to assess the conceptual model.FindingsThe results showed that supervisor EPM use was positively related to sense of power, which in turn positively related to supervisor undermining. Furthermore, supervisors' individual identity orientation moderates the relationship between supervisor EPM use and sense of power, as well as the indirect relationship between supervisor EPM use and supervisor undermining through sense of power.Practical implicationsThis study advocates for responsible EPM use to mitigate supervisor undermining (e.g. making subordinates feel incompetent) and minimize negative leadership behaviors.Originality/valueThe presented results signify a substantial progression in comprehending the interplay between supervisor EPM use and individual identity orientation, and their combined impact on the sense of power and subsequent supervisor undermining.
Publish or perish in the era of artificial intelligence: which way for the Kenyan research community?
Authors: Ajwang Stephen Oloo , Ikoha Anselimo Peters 
Published: June 2024

Purpose
This study aims to shed light on the dilemma of “publish or perish” within the context of artificial intelligence (AI) and to suggest approaches that scholars and organizations can implement to enhance ethical behavior in research and publishing.

Design/methodology/approach
This investigation examined institutional guidelines, policies, processes, norms and prior research to pinpoint ethical patterns that could be leveraged to promote ethical behavior in research and publishing.

Findings
The research outlined various unethical behaviors that have a detrimental impact on research outcomes including falsification, fabrication, plagiarism, p-hacking, authorship conflicts of interest, salami publication, republishing and manipulation of visual data, as well as incorrect selection of statistical analysis techniques. Furthermore, the study recommends optimal strategies for researchers and institutions to improve the quality of research, such as embracing the Open Research Library, forming partnerships and consortia, adhering to established informed consent standards and safeguarding confidentiality and privacy, among other practices.

Practical implications
These findings can serve as a foundation for policies that enable institutions and scholars to heighten their comprehension of ethical research practices and establish mechanisms for supervising research outcomes.

Originality/value
Numerous research and educational institutions are contending with new obstacles brought about by using technologies such as AI. These findings can offer a reference point to stimulate the ongoing discourse regarding the utilization of generative AI in academic settings.
Rightwing populism and public opinion on the Covid‐19 pandemic in Sweden: The role of strategic party positioning and political cues
Authors: Kulin Joakim , Johansson Sevä Ingemar 
Published: June 2024

AbstractDuring the early stages of the Covid‐19 pandemic, the Swedish government did not implement the hard lockdowns and coercive measures found in many countries and instead relied on voluntary social distancing measures and work‐from‐home initiatives. Unlike its international counterparts in most countries, the rightwing populist party in Sweden early on took a critical approach toward the government's handling of the Covid‐19 pandemic, calling for stricter government measures to curb virus transmission. Based on theories about strategic party positioning, and theories about political elite cues and framing effects, we use Swedish survey data from the early stages of the pandemic to show that the views of rightwing populist party supporters aligned with the rhetoric of the Swedish rightwing populist party in demanding more (rather than less) government intervention to curb the spread of SARS‐COV‐2. Our results suggest that they did so by drawing on core rightwing populist themes of anti‐elitism and nationalism. Hence, our results speak to the role of elite cues and framing in public opinion formation during times of crisis, particularly among rightwing populists, who generally opposed stricter government measures to fight the Covid‐19 pandemic.
Young people’s use of disposable vapes: A qualitative study
Authors: Notley Caitlin , Varley Anna , Pope Ian , Dawkins Lynne , Ward Emma 
Published: June 2024

AbstractBackground and aimsYouth use of disposable vapes has increased markedly in the United Kingdom in recent years, yet little is known about the motivations, experiences and perceptions of young people themselves. This study aimed to explore young people’s experiences and use of disposable vapes.MethodsThis was a qualitative study recruiting young people reporting regularly vaping disposables, collecting data via dyad guided, individual and group interviews. Data analysis was theoretically informed by the Social Ecological Model. Inductive and deductive coding approaches were used, with resolution of coded interpretations by consensus.ResultsTwenty‐nine young people aged 16–20 years participated in qualitative interviews. At the individual level, participants discussed how characteristics of disposable vapes were important to them—particularly price, accessibility and the attractive designs, colours, names and flavours. Young people frequently engaged in both vaping and tobacco smoking, seeing the behaviours as interchangeable dependent on context, and having inaccurate relative harm perceptions of vaping compared with smoking. Experimentation was widespread and many used vapes as a way of managing stress and anxiety. Vaping was positioned as a social behaviour, common among peers. Parental influence on vaping behaviour was minimal, although vaping initiation could be influenced by family vaping norms. Culturally, vaping was a widespread normalized behaviour. Young people were aware of media reports and potential harms, but were less aware of smoking related harms as a consequence.ConclusionsDisposable vapes appear to be attractive and accessible to young people in the United Kingdom. Vaping is normalized in this population, despite being seen as potentially damaging to health, and vaping and smoking are engaged in interchangeably. Underage sales of vapes are reportedly widespread. Strict regulation, such as banning products or increasing prices, may prompt UK youth to switch from vaping to smoking.
Comprehensive Analysis of Damage Associated SNPs of Luteinizing Hormone and Its Receptor: A Computational Approach
Authors: Bhatnager Richa , Gaba Kajal , Dang Amita Suneja 
Published: June 2024

ABSTRACTProblemThe luteinizing hormone (LH), produced by gonadal and nongonadal cells in the anterior pituitary gland play a critical role in human sexual development and reproduction. It is required for the induction of ovulation in females and sex steroid hormone production in both males and females. It is also an important player in early pregnancy events in oviducts and in absence of LH signalling, the uterus cannot initiate pregnancy. LH works through its receptor LHCGR. Therefore, it is quite important to figure out those mutations that have the potential to affect the structure and function of both LH and LHR.Materials and MethodsVarious in silico tools were employed in the study for the data mining of SNPs and predicting their possible impact on the structure and function of the protein. ConSurf analysis predicted V454I and I161K are exposed residues in the 2D structure of protein and highly conserved in protein structure. PSIPRED and Swiss Modeller were employed to predict the 2D and 3D structure of mutated receptor protein. FT site server predicted both substitutions were involved in the ligand‐binding siteResultsBy present analysis, we have found that R59G in LHα, Q74R and T78N in LHβ and V454I and I161K in LHCGR are the most deleterious nsSNPs affecting the structure and function of the protein.ConclusionThese SNPs are still uncharacterised; hence providing a baseline for validation of their association with the susceptibility of diseases and develop personalised therapeutics.
Clinical implication of PRAME immunohistochemistry in differentiating melanoma in situ and dysplastic nevus in non‐acral nevus‐associated melanoma in situ: An institutional experience and meta‐analysis
Authors: Bui Chau M. , Vuong Huy Gia , Le Minh‐Khang , D'Angelo Josephine , Mannava Kathleen , Smoller Bruce R. 
Published: June 2024

AbstractIntroductionPReferentially expressed Antigen in MElanoma (PRAME) has shown utility in differentiating benign from malignant melanocytic neoplasms. In this study, we investigated the clinical significance of PRAME expression in dysplastic nevi (DN) and nevus‐associated melanoma in situ (MIS).MethodsWe included 172 DN and 38 nevus‐associated MIS from our institutional archive. PRAME positive expression was defined as nuclear staining in at least 75% of melanocytes. In addition, relevant studies from PubMed and Web of Science were incorporated into a meta‐analysis using the random‐effects model to assess PRAME expression in MIS and DN.ResultsOur institutional data revealed that 71.1% of nevus‐associated MIS cases exhibited positive PRAME expression in the MIS components, whereas all DN components were negative for PRAME. 5.7% of cases diagnosed as DN in our cohort demonstrated diffuse positivity for PRAME. Notably, MIS associated with DN displaying epidermal and dermal components displayed a higher likelihood of PRAME positivity compared to those arising on a background of DN with solely epidermal (junctional) components (84% vs. 46%, p = 0.024). The meta‐analysis indicated that the pooled PRAME positivity in MIS and DN was 54.5% and 1.9%, respectively.ConclusionPRAME is a valuable immunohistochemical marker for differentiating MIS from DN, particularly in the context of nevus‐associated MIS.
1101. Spiranthes spiralis (L.) Chevall.
Authors: Fay Michael F. , Langhorne Joanna , Pace Matthew 
Published: June 2024

SummarySpiranthes spiralis (autumn lady's tresses) is illustrated here (Plate 1101). It is a widespread, mostly temperate European species, extending in south‐western Asian and North Africa. A detailed description is provided, with notes on cytology, habitat and conservation status. Advice on cultivation is also given.
Combination therapy for Sneddon syndrome to reduce the incidence of cerebrovascular complications
Authors: Narwutsch Albert , Wohlrab Johannes , Sperfeld Anne‐D. , Sunderkötter Cord 
Published: June 2024

SummaryBackgroundSneddon syndrome is an occlusive vasculopathy that presents clinically with generalized livedo racemosa on the skin and transient ischemic attacks, strokes, and cognitive or motor deficits in the central nervous system. Antiplatelet or anticoagulant therapy is recommended. Due to the limited therapeutic efficacy and the resulting serious complications, we propose combination therapy with additional infusion cycles of alprostadil and captopril and report initial long‐term results.Patients and methodsWe performed a systematic retrospective analysis of all patients with primary Sneddon syndrome who received combination therapy in our clinic between 1995 and 2020. Therapeutic outcomes were evaluated using descriptive statistics compared to historical controls receiving monotherapy. We also analyzed the event rate of complications when combination therapy was discontinued.ResultsDuring the 99.7 patient‐years of follow‐up, there were no transient ischemic attacks and the stroke rate dropped to 0.02 per patient‐year. In comparison, the rates of transient ischemic attacks and strokes in the historical controls ranged from 0.08 to 0.035 per patient‐year. After discontinuation of alprostadil therapy, eight events occurred in three patients.ConclusionsCombination therapy reduces the long‐term incidence of ischemic events in patients with primary Sneddon syndrome.
Motor behaviors in children with autism spectrum disorder with a neurotypical sibling
Authors: Lu Yuemei , Hauck Janet L. 
Published: June 2024

AbstractBackgroundChildren with autism spectrum disorder (ASD) can experience issues in motor development and fall short of physical activity (PA) recommendations. Family members, especially parents and siblings, play important roles in influencing their motor behaviors.ObjectiveThis study investigated motor behaviors (i.e., levels of PA, parent‐perceived motor competence, and related family dynamics) in children with ASD during a historical event—the COVID‐19 pandemic—during which most service approaches were not being used, and children with ASD were staying at home with their parents and neurotypical (NT) siblings.MethodsThis cross‐sectional study recruited 17 ASD–NT–parent triads (51 participants in total). Motor behaviors were all measured by questionnaires and surveys, with levels of PA also measured objectively using ActiGraph GT3X. Descriptive analyses were conducted.ResultsChildren with ASD participated in more types of sedentary activities than leisure‐time and sports activities. Parents perceived a low level of motor competence in their children with ASD, and compared with siblings, they perceived more interactions and higher self‐efficacy in supporting PA in children with ASD.ConclusionThe findings of this study can be helpful to us as we evolve our understanding and strategies to influence motor behaviors in children with ASD, ultimately to advance our service‐delivery model to include family‐based approaches.ImplicationsThis study should inform future ASD studies of the importance of providing quality family‐based PA/education programs for children with ASD and boosting parents' and NT siblings' self‐efficacy in supporting PA in children with ASD.