bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: One‐Pot Synthesis of Substituted Indolines via a Copper‐Catalyzed Sequential Multicomponent/C—N Coupling Reaction.
Authors: Jin Hongwei , Zhou Bingwei , Wu Zhi , Shen Yang , Wang Yanguang 
Published: May 2011

AbstractThe method involves a copper‐catalyzed reaction of o‐bromophenylacetylenes with sulfonyl azides and primary amines to give sulfonamides, which undergo a subsequent copper‐catalyzed intramolecular C—N coupling to afford the desired 2‐(N‐sulfonylimino)indolines.
ChemInform Abstract: Indium‐Catalyzed Heteroaryl—Heteroaryl Bond Formation Through Nucleophilic Aromatic Substitution.
Authors: Tsuchimoto Teruhisa , Iwabuchi Mami , Nagase Yuta , Oki Kenji , Takahashi Hiroshi 
Published: May 2011

AbstractIn most cases, In(O‐Tf)3 is found to be the optimal catalyst.
ChemInform Abstract: Chemoselective Suzuki Cross‐Coupling Reactions of Chiral Pyrrolizines.
Authors: Lee Hyo‐Jun , Cho Chang‐Woo 
Published: May 2011

AbstractThe first examples of two consecutive Suzuki cross‐coupling reactions of dihalopyrrolizines furnishing unsymmetrically substituted diarylpyrrolizines are given.
ChemInform Abstract: Synthesis of Bis‐Pyrrole Tetra Esters and Alcohols as Novel Mimetics of the Anticancer Mitomycin (VI).
Authors: Abdulla Zubair M. , Iyer Radhakrishnan P. , Akamanchi Krishnamachari G. , Degani Mariam S. , Coutinho Evans C. 
Published: May 2011

AbstractOpen‐chain bis‐Reissert compounds (I) are converted in a one‐pot reaction to the corresponding bis‐pyrrole esters (III).
ChemInform Abstract: Synthesis of Some Derivatives Based on the 4‐Benzyl‐1H‐pyrazole‐3,5‐diamine core.
Authors: Jedinak Lukas , Krystof Vladimir , Cankar Petr 
Published: May 2011

AbstractA facile three‐step synthesis of the title pyrazole derivatives (IV) (15 examples) from commercially available aldehydes (I) involving a Knoevenagel condensation and cycloaddition step is developed.
ChemInform Abstract: Synthesis and Biological Evaluation of New 3‐Trifluoromethylpyrazolesulfonyl‐urea and Thiourea Derivatives as Antidiabetic and Antimicrobial Agents.
Authors: Faidallah Hassan M. , Khan Khalid A. , Asiri Abdullah M. 
Published: May 2011

AbstractTitle compounds are synthesized by reaction of pyrazoles (I) with isocyanates (II) or isothiocyanates (IV), resp., followed by intermolecular cyclization reactions.
ChemInform Abstract: Tandem Allylic Amination/Ring‐Opening/oxa‐Michael Addition Reactions of Chromone‐Derived Morita—Baylis—Hillman Acetates with Amines.
Authors: Wu Chen , Zeng Hao , Liu Li , Wang Dong , Chen Yongjun 
Published: May 2011

AbstractThe title reaction affords (E)‐ or (Z)‐2‐aryl‐3‐aminomethylene‐substituted chromanones from the reaction of acetates (I) with secondary or primary amines, correspondingly (15 examples).
ChemInform Abstract: Design, Synthesis and Characterization of Some Novel 3‐Coumarinyl‐5‐aryliden‐1,3‐thiazolidine‐2,4‐diones and Their Antioxidant Activity.
Authors: Cacic Milan , Molnar Maja 
Published: May 2011

AbstractA variety of the title compounds (III) (18 examples) is synthesized by condensation of compounds (II) with chromene (I).
ChemInform Abstract: Synthesis of 12‐Aryl‐12H‐benzo[i][1,3]‐dioxolo[4,5‐b]xanthene‐6,11‐diones Using Silica Sulfuric Acid as an Efficient and Versatile Catalyst under Solvent‐Free Conditions.
Authors: Wu Liqiang , Chao Shujun , Yan Fulin 
Published: May 2011

AbstractSilica sulfuric acid is shown to be the optimum catalyst for the three‐component reaction to give the title compounds (IV).
ChemInform Abstract: Cinchona‐Derived Ammonium Salt Catalyzed Aza Diels—Alder Reaction of Danishefsky′s Diene with Imines.
Authors: Park Yohan , Park Eunyoung , Jung Hyojun , Lee Yeon‐Ju , Jew Sang‐sup , Park Hyeung‐geun 
Published: May 2011

AbstractAmong 9 cinchonidine‐derived catalysts tested in the reaction of diene (II) with imine (IIIa), compound (I) exhibits the highest yield of pyridone (IVa) and is applied to study the scope of the reaction with other (E)‐imines as well as cyclic imines.
ChemInform Abstract: Ir‐Catalyzed Highly Selective Addition of Pyridyl C—H Bonds to Aldehydes Promoted by Triethylsilane.
Authors: Li Bi‐Jie , Shi Zhang‐Jie 
Published: May 2011

AbstractIn the iridium‐catalyzed reaction the unfunctionalized pyridine is used as the Grignard reagent surrogate.
ChemInform Abstract: Synthesis and Applications of Sulfur‐Substituted cis‐Hexahydro‐2‐quinolinones.
Authors: Chou Shang‐Shing P. , Cai Yi‐Lin 
Published: May 2011

AbstractBicyclic sulfolene (I) and isocyanate (II) are transformed by an aza‐Diels—Alder reaction into quinolinone (III), which under basic conditions is isomerized to cis‐quinolinone (IV).
ChemInform Abstract: Chiral Amine‐Triggered Triple Cascade Reactions: A New Approach to Functionalized Decahydroquinolines.
Authors: Rai Ankita , Singh Atul K. , Singh Santosh , Yadav Lal Dhar S. 
Published: May 2011

AbstractThe highly enantio‐ and diastereoselective one‐pot synthesis of the pharmaceutically interesting substructures (IV) involves a [2 + 2 + 2] annulation of cyclohexanone with nitroalkenes followed by aza‐Henry hemiaminalization.
ChemInform Abstract: CsxH3‐xPW12O40 Heteropoly Salts Catalyzed Quinoline Synthesis via Friedlaender Reaction.
Authors: Rafiee Ezzat , Nejad Fereshte Khajooei , Joshaghani Mohammad 
Published: May 2011

AbstractThe salt is found to be an efficient reusable catalyst for the reaction of 2‐aminoacetophenone (I) with various activated α‐methylene compounds to give quinolines under solvent‐free conditions and short reaction times.
ChemInform Abstract: An Asymmetric Organocatalytic One‐Pot Strategy to Octahydroacridines.
Authors: Dickmeiss Gustav , Jensen Kim L. , Worgull Dennis , Franke Patrick T. , Joergensen Karl Anker 
Published: May 2011

AbstractThe synthesis involves the addition of α,β‐unsaturated aldehydes to malonitrile derivative (I) followed by condensation with anilines and cyclization.
ChemInform Abstract: Synthesis, Topoisomerase I and II Inhibitory Activity, Cytotoxicity, and Structure—Activity Relationship Study of Rigid Analogues of 2,4,6‐Trisubstituted Pyridine Containing 5,6‐Dihydrobenzo[h]quinoline Moiety.
Authors: Lee Eung‐Seok , et al. et al. 
Published: May 2011

AbstractA variety of (het)aryl‐substituted benzoquinoline derivatives (III) (24 examples) is designed, synthesized and evaluated for their topoisomerase inhibitory activities and their cytotoxicity against several human cancer cell lines.
ChemInform Abstract: Facile and Efficient Generation of Quinolone Amides from Esters Using Aluminum Chloride.
Authors: Schwaebe Michael K. , Ryckman David M. , Nagasawa Johnny Y. , Pierre Fabrice , Vialettes Anne , Haddach Mustapha 
Published: May 2011

AbstractThe use of AlCl3 as an activating agent allows the conversion of quinolone esters into amides, which in many cases are not obtainable through traditional amide bond formation from their corresponding carboxylic acids.
ChemInform Abstract: An Efficient Route to Diverse H‐Pyrazolo[5,1‐a]isoquinolines via Sequential Multi‐Component/Cross‐Coupling Reactions.
Authors: Yu Xingxin , Pan Xiaolin , Wu Jie 
Published: May 2011

AbstractThe reaction of 2‐alkynylbenzaldehydes with sulfonohydrazide and either bromine or iodine, followed by reaction with an aldehyde or ketone affords the corresponding bromo‐ or iodo‐substituted title compounds which undergo Suzuki—Miyaura cross‐coupling reactions.
ChemInform Abstract: Direct Asymmetric Michael Addition of Cyclic N‐Sulfonylimines to α,β‐Unsaturated Aldehydes.
Authors: Xiong Xiao‐Feng , Zhang Hang , Peng Jing , Chen Ying‐Chun 
Published: May 2011

AbstractSaccharin‐derived cyclic imines such as (I) can be used as direct nucleophiles in the asymmetric Michael reaction with α,β‐unsaturated aldehydes such as (II) by using the iminium catalyst of a chiral secondary amine.
ChemInform Abstract: Synthesis and Pharmacological Properties of N‐Substituted‐N′‐(4,6‐dimethylpyrimidin‐2‐yl)‐thiourea Derivatives and Related Fused Heterocyclic Compounds.
Authors: Saeed Sohail , Rashid Naghmana , Jones Peter G. , Tahir Arifa 
Published: May 2011

AbstractTitle compounds (IV) and their intramolecular cyclization products (V) are prepared and tested for their antifungal and antibacterial activities.
ChemInform Abstract: A Rapid and Convenient Synthesis of 5‐Unsubstituted 3,4‐Dihydropyrimidin‐2‐ones and Thiones.
Authors: Fang Zhanxiong , Lam Yulin 
Published: May 2011

AbstractThe multicomponent, microwave assisted cyclocondensation reaction of keto acid (I) with aromatic aldehydes and either ureas or thioureas proceeds within minutes compared to several hours using conventional heating.
ChemInform Abstract: Melamine Trisulfonic Acid: A New, Efficient and Recyclable Catalyst for the Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐ones/thiones in the Absence of Solvent.
Authors: Shirini Farhad , Zolfigol Mohammad Ali , Albadi Jalal 
Published: May 2011

AbstractThe novel method is advantageous with regards to high yields, short reaction times and easy work‐up.
ChemInform Abstract: Synthetic Utility of a Heterocyclic o‐Aminoaldehyde: Synthesis of Pyrazolopyridopyrimidines, Pyrazolonaphthyridines, and Pyrazolopyrimidonaphthyridinones.
Authors: Bagul Sandeep M. , Birari Dilip R. , Ghagare Maruti G. , Toche Raghunath B. , Jachak Madhukar N. 
Published: May 2011

AbstractA variety of novel pyrazolo‐annulated heterocycles are synthesized by Friedlaender condensation reactions of o‐aminoaldehyde (I).
ChemInform Abstract: Synthesis and Reactions of a New Series of 1,2,4‐Triazolo[4,3‐c]quinazolines.
Authors: Atta Kamal F. M. , Marei Mohamed G. , Mohamed Fatma A. M. 
Published: May 2011

AbstractA variety of triazoloquinazoline derivatives bearing various mono‐ or fused heterocyclic azole moieties is synthesized.
ChemInform Abstract: Synthesis of 1H‐1,5,7‐Triazacyclopenta[c,d]phenalenes by the Electrophilic Amination of Perimidines Using Sodium Azide in PPA.
Authors: Aksenov A. V. , Kyakhovnenko A. S. , Andrienko A. V. 
Published: May 2011

AbstractThe feasibility of the peri‐annelation of the pyrrole ring to obtain perimidines by means of electrophilic amination using sodium azide in PPA is demonstrated.
ChemInform Abstract: Concise Asymmetric Formal Synthesis of Pyrrolopiperazinone Natural Products by Tandem Cross Metathesis/Intramolecular Aza‐Conjugate Addition.
Authors: Kwon Su‐Hyun , Lee Hyo‐Jun , Cho Chang‐Woo 
Published: May 2011

AbstractThe tandem cross metathesis and intramolecular aza‐conjugate addition reactions of amide (III) with acrolein lead to a mixture of diastereomers (V) and (VI).
ChemInform Abstract: Aminomethylation via Cyclopalladated‐Ferrocenylimine‐Complexes‐Catalyzed Suzuki—Miyaura Coupling of Aryl Halides with Potassium N,N‐Dialkylaminomethyltrifluoroborates.
Authors: Zou Dapeng , Cui Hongmeng , Qin Lijin , Li Jingya , Wu Yangjie , Wu Yusheng 
Published: May 2011

AbstractFER‐XPhos is found to be the most active catalyst for the title process to provide aminomethylated arenes in moderate to good yields.
ChemInform Abstract: Nitrogen‐Directed Ketone Hydroacylation: Enantioselective Synthesis of Benzoxazecinones.
Authors: Khan Hasan A. , Kou Kevin G. M. , Dong Vy M. 
Published: May 2011

AbstractCatalytic lactonization furnishes chiral benzoxazepinones (II) and benzoxazecinones (IV) in high yields and enantioselectivities.
ChemInform Abstract: One‐Pot Preparation of Hydroxylated Potassium Organotrifluoroborates and Subsequent Jones Oxidation to Potassium Organocarbonyltrifluoroborates.
Authors: Kim Dong‐Su , Bolla Krishnavenu , Lee Seokjoon , Ham Jungyeob 
Published: May 2011

AbstractDibromobenzenes (I) or (VII) and a range of aromatic and aliphatic aldehydes are sequentially transformed into alcohol‐containing organotrifluoroborates via lithium—halogen exchange reactions.
ChemInform Abstract: Synthesis of Cyclic β‐Silylenones via Oxidative Rearrangement of Tertiary α‐Hydroxy Allylsilanes with PCC.
Authors: Wu Xia , Lei Jian , Song Zhen Lei 
Published: May 2011

AbstractThe reaction provides six‐membered cyclic β‐silylenones (II) in moderate yields, whereas the five‐membered product (IV) is achieved in excellent yield.
ChemInform Abstract: Stereoselective Synthesis of (E)‐α‐Fluorovinylphosphonates from α,α‐Difluorophosphonates.
Authors: Cherkupally Prabhakar , Slazhnev Anton , Beier Petr 
Published: May 2011

AbstractPhosphonates of type (I) and (III) undergo elimination of HF to provide the target compounds.
ChemInform Abstract: Iron(III) Chloride‐Tandem Catalysis for a One‐Pot Regioselective Protection of Glycopyranosides.
Authors: Bourdreux Yann , Lemetais Aurelie , Urban Dominique , Beau Jean‐Marie 
Published: May 2011

AbstractThe successful introduction of orthogonal protecting groups into glucose, maltose, and trehalose derivatives is elaborated using the iron‐catalyzed tandem reductive etherification—acetylation of persilylated carbohydrates with benzaldehyde in the presence of triethylsilane.
ChemInform Abstract: In vitro and in vivo Antimalarial Activity of Puberulic Acid (Ia) and Its New Analogues, Viticolins A—C (Ib), (Ic), (II), resp., Produced by Penicillium sp. FKI‐4410.
Authors: Otoguro Kazuhiko , et al. et al. 
Published: May 2011

AbstractAmong the title compounds, puberulic acid (Ia) exhibits potent antimalarial inhibition of chloroquine‐sensitive and ‐resistant Plasmodium strains in vitro.
ChemInform Abstract: Marinactinones A—C, New γ‐Pyrones from Marine Actinomycete Marinactinospora thermotolerans SCSIO 00606
Authors: Wang Fazuo , Tian Xinpeng , Huang Caiguo , Li Qingxin , Zhang Si 
Published: May 2011

Abstractisolation, structure determination and cytotoxicity of the title compounds (I)
ChemInform Abstract: Sterigmatocystins from the Deep‐Sea‐Derived Fungus Aspergillus versicolor
Authors: Cai Shengxin , Zhu Tianjiao , Du Lin , Zhao Boyu , Li Dehai , Gu Qianqun 
Published: May 2011

Abstractisolation, structure and cytotoxicities of three new sterigmatocystins, oxisterigmatocystins A—C (I)
ChemInform Abstract: A General Solution Route Toward Metal Boride Nanocrystals.
Authors: Portehault David , Devi Sarala , Beaunier Patricia , Gervais Christel , Giordano Cristina , Sanchez Clement , Antonietti Markus 
Published: May 2011

AbstractNanocrystals of NbB2, CaB6, HfB2, CeB6, MoB4, FeB, and Mn2B are prepared by reaction of the corresponding metal chlorides and sodium borohydride in a eutectic LiCl/KCl melt (Ar flow, 700—900 °C, 4 h).
ChemInform Abstract: Liquid—Liquid Equilibria of (Ionic Liquid + Hydrocarbon) Binary Systems and Their Modeling by the Conductor‐Like Screening Model for Real Solvents
Authors: Ferreira Ana R. , Freire Mara G. , Ribeiro Jorge C. , Lopes Fernando M. , Crespo Joao G. , Coutinho Joao A. P. 
Published: May 2011

AbstractReview: 73 refs.
ChemInform Abstract: Whole‐Cell Based Hybrid Materials for Green Energy Production, Environmental Remediation and Smart Cell‐Therapy
Authors: Leonard Alexandre , Dandoy Philippe , Danloy Emeric , Leroux Gregory , Meunier Christophe F. , Rooke Joanna C. , Su Bao‐Lian 
Published: May 2011

AbstractReview: 264 refs.
A practical equation of state for non‐spherical and asymmetric systems for application at high pressures. Part 1: Development of the pure component model
Authors: du Rand Marlie , Nieuwoudt Izak , Schwarz Cara E. , Knoetze Johannes H. 
Published: May 2011

AbstractA practical, mathematically and computationally simple, equation of state (EOS) has been developed to accurately describe pure component phase behaviour of spherical and chain‐like molecules. The EOS consists of a newly developed hard sphere model and a perturbation term based on the Barker and Henderson approach using the Chen and Kreglewski intermolecular potential model and a double constrained summation as a mathematical expression thereof. The perturbed hard chain theory (PHCT) approach is used to extend the EOS to non‐spherical molecules. The EOS compares well with other more complex models such as the simplified perturbed hard chain theory (SPHCT) and statistically associating fluid theory (SAFT) models and will be extended to describe mixtures in Part 2 of this series. © 2011 Canadian Society for Chemical Engineering
Optimisation of reaction conditions for the synthesis of single‐walled carbon nanotubes using response surface methodology
Authors: Liu Wei‐Wen , Aziz Azizan , Chai Siang‐Piao , Mohamed Abdul Rahman , Tye Ching‐Thian 
Published: May 2011

AbstractThe effects of three preparation variables, i.e. reaction temperature, reaction time and reaction gas (methane/nitrogen) flow rate, on the ratio of the intensity of the Raman D band to the intensity of the G band (ID/IG), carbon mass and the presence of radial breathing mode (RBM) peaks were investigated by using a central composite design to develop two linear models. The most influential factor in each experimental design‐response was identified using the analysis of variance. The predicted ID/IG ratio, carbon mass and presence of RBM peaks determined during the process optimisation were found to agree satisfactorily with the experimental values. The optimum conditions for synthesising single‐walled carbon nanotubes were determined to be a reaction temperature of 900°C, a reaction time of 59 min and a reaction gas flow rate of 54 mL/min. © 2011 Canadian Society for Chemical Engineering
Removal of nickel from aqueous solutions by citric acid modified Ceiba pentandra hulls: Equilibrium and kinetic studies
Authors: Ramana D. K. Venkata , Reddy D. Harikishore Kumar , Kumar B. Naresh , Harinath Y. , Seshaiah K. 
Published: May 2011

AbstractThe removal of Ni(II) from aqueous solutions using biomass prepared from Ceiba pentandra hulls powder modified with citric acid treatment (CAMCPH) has been studied by batch method. The biosorbent was characterised before and after citric acid modification using SEM, FT‐IR and XRD. Experimental parameters that influence the biosorption of Ni(II), such as pH, biosorbent dose, contact time and initial concentration of metal ion have been investigated. The adsorption of Ni(II) increased with increase in contact time and reached equilibrium within 50 min. The maximum removal of Ni(II) was observed at pH 5.0. The kinetic data were analysed using three adsorption kinetic models: the pseudo‐first, second‐order kinetics and intra‐particle diffusion. The results showed that the pseudo‐second‐order model fits the experimental data very well. The equilibrium data were analysed using Langmuir, Freundlich and Dubinin–Radushkevich isotherm models. Langmuir model provided the best correlation for the adsorption of Ni(II) by CAMCPH and the monolayer biosorption capacity for Ni(II) removal was 34.34 mg/g. Desorption experiments were carried out using HCl solution and the recovery of the metal ion from CAMCPH was found 98%. Desorption experiments showed the feasibility of regeneration of the biosorbent for further use after treating with dilute HCl. © 2011 Canadian Society for Chemical Engineering
Delineation of the Molecular Mechanisms of Nucleoside Recognition by Cytidine Deaminase through Virtual Screening
Authors: Costanzi Stefano , Vilar Santiago , Micozzi Daniela , Carpi Francesco M. , Ferino Giulio , Vita Alberto , Vincenzetti Silvia 
Published: May 2011

AbstractCytidine deaminase (EC 3.5.4.5, CDA), an enzyme of the pyrimidine salvage pathways, is responsible for the degradation and inactivation of several cytidine‐based antitumor drugs such as cytarabine, gemcitabine, decitabine, and azacytidine. Thus, CDA inhibitors are highly sought after as compounds to be co‐administered with said drugs to improve their effectiveness. Alternatively, the design of antitumor drugs not susceptible to the action of CDA is also regarded as an attractive solution. Herein we describe a virtual screen for CDA ligands based on chemical similarity and molecular docking. The campaign led to the identification of three novel inhibitors and one novel substrate, with a 19 % hit rate, and allowed a significant extension of the structure–activity relationships, also in light of the compounds that resulted inactive. The most active compound identified through the screen is the inhibitor pseudoisocytidine, which has the potential to serve as a lead for highly stable compounds. The study also delineated the detrimental effect of 5‐aza and 6‐aza substitutions, the incompatibility of the presence of an amino group at the 3′‐position, as well as the presence of very strict steric requirements around the 2′‐arabino position and, even more, the N4‐position. Importantly, these features can be exploited for the design of novel anti‐neoplastic agents resistant to the action of CDA.
Omitting elective nodal irradiation and irradiating postinduction versus preinduction chemotherapy tumor extent for limited‐stage small cell lung cancer
Authors: Hu Xiao , Bao Yong , Zhang Li , Guo Ying , Chen Yuan Yuan , Li Kai Xin , Wang Wei Hua , Liu Yuan , He Han , Chen Ming 
Published: May 2011

AbstractBACKGROUND:Controversies exist with regard to thoracic radiotherapy volumes for limited‐stage small cell lung cancer (SCLC). This study compared locoregional progression and overall survival between limited‐stage SCLC patients who received thoracic radiotherapy to different target volumes after induction chemotherapy.METHODS:Chemotherapy consisted of 6 cycles of etoposide and cisplatin. After 2 cycles of etoposide and cisplatin, patients were randomly assigned to receive thoracic radiotherapy to either the postchemotherapy or prechemotherapy tumor extent as study arm or control. Elective nodal irradiation was omitted for both arms. Forty‐five Gy/30Fx/19 days thoracic radiotherapy was administered concurrently with cycle 3 chemotherapy. Prophylactic cranial irradiation was administered to patients who achieved complete remission. An interim analysis was planned when the first 80 patients had been followed for at least 6 months, for consideration of potential inferiority in the study arm.RESULTS:Forty‐two and 43 patients were randomly assigned to a study arm and a control, respectively. The local recurrence rates were 31.6% (12 of 38) and 28.6% (12 of 42), respectively (P = .81). The isolated nodal failure rates were 2.6% (1 of 38) and 2.4% (1 of 42), respectively (P = 1.00). All isolated nodal failure sites were in the ipsilateral supraclavicular fossa. Mediastinal N3 was the only factor to predict isolated nodal failure (P = .004; odds ratio [OR], 29.33; 95% CI, 2.94‐292.38). One‐year and 3‐year overall survival rates were 80.6%, 36.2%, and 78.9%, 36.4%, respectively (P = .54).CONCLUSIONS:Preliminary results indicated that irradiated postchemotherapy tumor extent and omitted elective nodal irradiation did not decrease locoregional control in the study arm, and the overall survival difference was not statistically significant between the 2 arms. Further investigation is warranted. Cancer 2012;. © 2011 American Cancer Society.