bluuebunny/crossref_metadata_2025_split huggingface dataset:
Water management in the Netherlands in transition
Authors: Kielen Neeltje 
Published: July 2010

AbstractThe Dutch have been intervening in the water environment to suit their needs and requirements from the early Middle Ages onwards. Technological development has always kept pace with these requirements. However, as a result of these requirements the functions in the occupation layer have become more and more out of balance with the natural underground layer, undermining the sustainability of the system. In the 1990s there came a turning point in water management. The near floods of 1993 and 1995, the droughts of 2003 and 2005 and the imminence of climate change made the water sector realise that the current water management system is approaching its physical, technical and economic boundaries. The current changes in water management have all the characteristics of a transition. Problems like climate change are complex, the future is highly uncertain and water management has become strongly intertwined with other social and economic domains. A robust, sustainable and climate‐proof layout of the Netherlands is not the responsibility of one actor alone; it has become the responsibility of all citizens. This has far‐reaching consequences for the role of the water expert. The water expert needs to become part of the transition arena and use his/her expertise to give direction and content to the transition. Copyright © 2009 John Wiley & Sons, Ltd.
The virtues of new water knowledge
Authors: Zwarteveen Margreet 
Published: July 2010

AbstractThis paper explores some of the implications of post‐positivism for water knowledge by answering the question: what is good water knowledge? I use Plato's four cardinal virtues, i.e. Fortitude, Temperance, Prudence and Justice, to answer the question. Fortitude means acknowledging that there are many different ways of making sense of water realities. Dominance of one view of reality over others may be related as much to the fact that it is the view of those in power, as to the accuracy with which it represents reality. Temperance refers to modesty about what is knowable. In water, it refers to the acceptance that there is much in water that we do not and cannot predict or know. Prudence refers to the wisdom to choose what is right (true) or wrong (false). It implies that producers of knowledge should be held accountable for the implications of their truth claims. And finally, Justice refers to the acknowledgement that the final test of water knowledge is not Truth, but a better world. The implication is that ideas, beliefs and visions about what a better world is should become an intrinsic part of water knowledge. Copyright © 2009 John Wiley & Sons, Ltd.
Decline of groundwater tables in the upper Yamuna basin: Causes and management strategies
Authors: Kumar Krishan , Gupta S. K. 
Published: July 2010

AbstractAmongst the three drainage basins in Haryana (India), the upper Yamuna and upper Ghaggar basins are experiencing groundwater table declines in good quality aquifers. Rice–wheat crop rotation widely adopted in this region is blamed for this situation. A number of groundwater regime maps were prepared to assess long‐term groundwater table behaviour in these basins. The water levels during the past three decades (1974–2004) registered an annual decline varying from 30 to 60 cm. The analysis revealed that a saving of 15 cm of water in rice–wheat cropping would be able to halt the declining groundwater table. The rainfall data of Kurukshetra district for the period (1974–2004) revealed that most surface drainage surplus could be used as additional surface storage in rice fields and for groundwater recharge. Evapotranspiration calculated using the FAO CROPWAT model revealed that the evapotranspiration (ET) of the short duration crop is about 88% of the normal rice crop (transplanted on 20 June), although its duration from transplanting to maturity is almost half of the normal rice crop. Similarly, the ET of the crop transplanted one month in advance of the normal rice crop is 25–30% more. It is believed that these two aberrations aggravated the groundwater table situation more than the rice–wheat cropping itself. The review through a desk study identified a number of management strategies that could help to save 15 cm or even more water in the rice–wheat system. It is concluded that it should be possible to sustain groundwater irrigation even with rice–wheat cropping (without aberrations) at the current level in these parts of the basins. Copyright © 2009 John Wiley & Sons, Ltd.
Effects of sulpiride on mRNA levels of steroid 5α‐reductase isozymes in prostate of adult rats
Authors: Sánchez Pilar , Torres Jesús M. , Vílchez Pablo , del Moral Raimundo G. , Ortega Esperanza 
Published: July 2010

AbstractProlactin (PRL) is implicated in prostate growth and in the development and regulation of benign prostatic hypertrophy (BPH) and prostate cancer (PCa). PRL may exert its effects on prostate in synergism with androgens. The most active androgen in the prostate is the 5α‐dihydrotestosterone (DHT) obtained from testosterone by the 5α‐reductase (5α‐R) enzyme, which is expressed in the prostate as two isozymes, 5α‐R1 and 5α‐R2. In this study, sulpiride, a prolactin‐secretion inductor, was administered to male rats. mRNA levels of 5α‐R1 and 5α‐R2 were measured in prostate of controls and sulpiride‐treated rats, using one‐step quantitative RT‐PCR coupled with laser‐induced fluorescence capillary electrophoresis (LIF‐CE). Results demonstrated that sulpiride‐induced hyperprolactinemia is associated with an increase in mRNA levels of both 5α‐R1 and 5α‐R2 in prostate of adult rats. Although a direct effect of sulpiride on prostate gland cannot be ruled out, hyperprolactinemia may be a factor to be considered in aging males, in whom prostatic diseases such as BPH and PCa are more frequent. © 2007 IUBMB IUBMB Life, 60(1): 68–72, 2008
First evidence for an LDL‐ and HDL‐associated nitratase activity that denitrates albumin‐bound nitrotyrosine—Physiological consequences
Authors: Léger Claude L. , Torres‐Rasgado Enrique , Fouret Gilles , Carbonneau Marie‐Annette 
Published: July 2010

AbstractIn the systemic circulation, LDL occurs in the form of a weakly nitrated LDL‐albumin complex (LAC). The question here is whether LAC (or HDL) is able to denitrate the albumin‐bound 3‐NO2‐tyrosine (3NT). Nitrated albumin was incubated in the presence of lipoprotein fraction (LPF) to be tested, with or without Ca2+. After precipitation and centrifugation, supernatants (SNs) and protein pellets (PP) were collected. HCl proteolysis was carried out with deuterated 3NT as an internal standard, and amino acids were derivatized for GC‐MS analysis, whereas SNs were used for NO2−/NO3−‐fluorimetric assays. A loss of 3NT, higher with albumin‐low LDL than with albumin‐rich LDL or HDL, was found in PP only in the presence of Ca2+. γ‐Tocopherol loading of LPF inhibited 3NT loss. 3NT loss was found for the first time to be stoichiometrically equivalent to NO3−, proving that the 3NT loss must be ascribed to a 3NT‐denitrating nitratase activity. 3NT loss and NO3− production that clearly cannot be attributed to PON‐1 were impaired by D‐penicillamine and phenylacetate, inhibitor, and substrate of PON‐1, respectively, leading to speculate on the active site. Finally, nitratase activity and albumin contribute to beneficially convert peroxynitrite (ONOO−) into nonbioactive NO3−. But, in inflammatory conditions, xanthine oxidoreductase is expressed leading to detrimentally reduce O2 and NO3− into O2•− and NO• that may interact, reconstituting the ONOO− pool. The real consequence of nitratase activity and the physiological significance of nitration/denitration processes remain to be explored. © 2007 IUBMB IUBMB Life, 60(1): 73–78, 2008
Mechanism of light‐induced translocation of arrestin and transducin in photoreceptors: Interaction‐restricted diffusion
Authors: Slepak Vladlen Z. , Hurley James B. 
Published: July 2010

AbstractMany signaling proteins change their location within cells in response to external stimuli. In photoreceptors, this phenomenon is remarkably robust. The G protein of rod photoreceptors and rod transducin concentrates in the outer segments (OS) of these neurons in darkness. Within ∼30 minutes after illumination, rod transducin redistributes throughout all of the outer and inner compartments of the cell. Visual arrestin concurrently relocalises from the inner compartments to become sequestered primarily within the OS. In the past several years, the question of whether these proteins are actively moved by molecular motors or whether they are redistributed by simple diffusion has been extensively debated. This review focuses on the most essential works in the area and concludes that the basic principle driving this protein movement is diffusion. The directionality and light dependence of this movement is achieved by the interactions of arrestin and transducin with their spatially restricted binding partners. © 2007 IUBMB IUBMB Life, 60(1): 2–9, 2008
Chaperones as integrators of cellular networks: Changes of cellular integrity in stress and diseases
Authors: Palotai Robin , Szalay Máté S. , Csermely Péter 
Published: July 2010

AbstractThe complex integrity of the cells and its sudden, but often predictable changes can be described and understood by the topology and dynamism of cellular networks. All these networks undergo both local and global rearrangements during stress and development of diseases. Here, we illustrate this by showing the stress‐induced structural rearrangement of the yeast protein–protein interaction network (interactome). In an unstressed state, the yeast interactome is highly compact, and the centrally organized modules have a large overlap. During stress, several original modules became more separated, and a number of novel modules also appear. A few basic functions such as theproteasome preserve their central position; however, several functions with high energy demand, such the cell‐cycle regulation loose their original centrality during stress. A number of key stress‐dependent protein complexes, such as the disaggregation‐specific chaperone, Hsp104 gain centrality in the stressed yeast interactome. Molecular chaperones, heat shock, or stress proteins became established as key elements in our molecular understanding of the cellular stress response. Chaperones form complex interaction networks (the chaperome) with each other and their partners. Here, we show that the human chaperome recovers the segregation of protein synthesis‐coupled and stress‐related chaperones observed in yeast recently. Examination of yeast and human interactomes shows that chaperones 1) are intermodular integrators of protein–protein interaction networks, which 2) often bridge hubs and 3) are favorite candidates for extensive phosphorylation. Moreover, chaperones 4) become more central in the organization of the isolated modules of the stressed yeast protein–protein interaction network, which highlights their importance in the decoupling and recoupling of network modules during and after stress. Chaperone‐mediated evolvability of cellular networks may play a key role in cellular adaptation during stress and various polygenic and chronic diseases, such as cancer, diabetes or neurodegeneration. © 2007 IUBMB IUBMB Life, 60(1): 10–18, 2008
Flavohemoglobin: Structure and reactivity
Authors: Bonamore Alessandra , Boffi Alberto 
Published: July 2010

AbstractFlavohemoglobins (flavoHbs) are made of a globin domain fused with a ferredoxin reductaselike FAD‐ and NAD‐binding modules. These proteins are widely represented among bacteria and yeasts and represent a most challenging research subject in view of their high reactivity both as reductases and as oxidases. The functional annotations of flavoHbs are still controversial, and different physiological roles that are linked to cell responses to oxidative and/or nitrosative stress have been proposed. The flavoHb from Escherichia coli (HMP) has been the object of a large number of investigations to unveil its physiological role in the framework of bacterial resistance to nitrosative stress. HMP expression has been demonstrated to respond to the presence of NO in the culture medium, and an explicit mechanism has been proposed that involves NO scavenging and its reduction to N2O under anaerobic conditions. In contrast to (or together with) the anaerobic NO‐reductase activity, HMP has also been shown to be able to catalyze the oxidation of NO to NO3− (NO‐dioxygenase activity) both in vivo and in vitro in the presence of O2 and NADH. HMP has also been shown to be capable of catalyzing the reduction of several alkylhydroperoxide substrates into their corresponding alcohols using NADH as an electron donor. The alkylhydroperoxide reductase activity taken together with the unique lipid‐binding properties of HMP suggests that this flavoHb may be involved in the repair of the lipid membrane oxidative damage generated during oxidative/nitrosative stress. © 2007 IUBMB IUBMB Life, 60(1): 19–28, 2008
Ifosfamide metabolite chloroacetaldehyde inhibits cell proliferation and glucose metabolism without decreasing cellular ATP content in human breast cancer cells MCF‐7
Authors: Knouzy Burhan , Dubourg Laurence , Baverel Gabriel , Michoudet Christian 
Published: July 2010

AbstractChloroacetaldehyde (CAA), a product of hepatic metabolism of the widely used anticancer drug ifosfamide (IFO), has been reported to decrease cancer cell proliferation. The basis of this effect is not completely known but has been attributed to a drop of cellular ATP content. Given the importance of glucose metabolism and of the ‘Warburg effect’ in cancer cells, we examined in the present study the ability of CAA to inhibit cancer cell proliferation by altering the glycolytic pathway. Cell proliferation, ATP content, glucose transport and metabolism as well as the activities of the main enzymes of glycolysis were determined in human breast cancer cells MCF‐7 in the presence of various CAA concentrations (5–50 μm). Our results show that low CAA concentrations inhibited cell proliferation in a concentration‐dependent manner. This inhibition was explained by a decrease in glucose utilization. Cellular ATP content was not reduced but even increased with 25 μmCAA. The inhibition of glucose metabolism was mainly explained by the decrease in glucose transport and hexokinase activity. The activity of glyceraldehyde‐3‐phosphate dehydrogenase, but not that of phosphofructokinase, was also inhibited. Glycolysis inhibition by CAA was effective in decreasing the proliferation of MCF‐7 cells. Interestingly, this decrease was not due to ATP depletion; rather, it was linked to a drop of biosynthetic precursors from glycolytic intermediates. This CAA‐induced inhibition of cell proliferation suggests that it might play a role in the antitumor activity of IFO. Copyright © 2009 John Wiley & Sons, Ltd.
Complete enumeration of pure‐level and mixed‐level orthogonal arrays
Authors: Schoen Eric D. , Eendebak Pieter T. , Nguyen Man V. M. 
Published: July 2010

AbstractWe specify an algorithm to enumerate a minimum complete set of combinatorially non‐isomorphic orthogonal arrays of given strengtht, run‐sizeN, and level‐numbers of the factors. The algorithm is the first one handling general mixed‐level and pure‐level cases. Using an implementation in C, we generate most non‐trivial series fort=2,N≤28,t=3,N≤64, andt=4,N≤168. The exceptions define limiting run‐sizes for which the algorithm returns complete sets in a reasonable amount of time. © 2009 Wiley Periodicals, Inc. J Combin Designs 18: 123–140, 2010
Cognitive and psychodynamic mechanisms of change in treated and untreated depression
Authors: Coleman Daniel , Cole Diane , Wuest Leslie 
Published: July 2010

AbstractTwo patient‐level mechanisms of change, defenses, and cognition were tested over 3 time points in 65 depressed adults, approximately half receiving treatment. Early changes in automatic thoughts and immature defenses were associated with symptom change from time‐one to time‐three. The directionality of early automatic thought change predicting symptom change was partially supported, but immature defense change occurs simultaneously with, or after, symptom change. Given the convergent evidence of cognitive change as a mediator of depression reduction, all depression therapies should consider how they address depressive cognition. To build a more complete understanding of how to ameliorate depression, future studies should continue to include constructs from multiple theories and have measures of therapy process in addition to patient level mechanisms. © 2009 Wiley Periodicals, Inc. J Clin Psychol 66: 215–228, 2010.
Doxazosin treatment alters stromal cell behavior and increases elastic system fibers deposition in rat prostate
Authors: Delella Flávia Karina , Felisbino Sérgio Luis 
Published: July 2010

AbstractDoxazosin (DOX), an α‐adrenoceptor antagonist, induces the relaxation of smooth muscle cell tonus and reduces the clinical symptoms of benign prostatic hyperplasia (BPH). However, the effects of DOX in the prostate stromal microenvironment are not fully known. In a previous study, we showed that DOX treatment for 30 days increased deposition of collagen fibers in the three rat prostatic lobes. Herein, we investigated the effects of DOX on stromal cell ultrastructure and elastic fiber deposition. Adult Wistar rats were treated with DOX (25 mg/kg/day); and the ventral, dorsal, and anterior prostates were excised at 30 days of treatment. The prostatic lobes were submitted to histochemical and stereological‐morphometric analyze and transmission electron microscopy (TEM). Histochemical staining plus stereological analysis of the elastic fiber system showed that DOX‐treated prostatic lobes presented more elaunin and elastic fibers than controls, mainly in the ventral lobe. Ultrastructural analysis showed that fibroblasts and smooth muscle cells from DOX‐treated prostates presented active synthetic phenotypes, evidenced by enlarged rough endoplasmic reticulum and Golgi apparatus cisterns, and confirmed the observation of thickened elaunin fibers. Our findings suggest that, under α‐adrenergic blockade by DOX, the fibroblasts become more active and smooth muscle cells shift from a predominantly contractile to a more synthetic phenotype. The deposition of collagen and elastic system fibers in the prostatic stroma may counterbalance the absence of smooth muscle tone during α‐blockers treatment. Microsc. Res. Tech. 73:1036–1044, 2010. © 2010 Wiley‐Liss, Inc.
Subgraph‐avoiding coloring of graphs
Authors: Shen Jia 
Published: July 2010

AbstractGiven a “forbidden graph” F and an integer k, an F‐avoiding k‐coloring of a graph G is a k‐coloring of the vertices of G such that no maximal F‐free subgraph of G is monochromatic. The F‐avoiding chromatic number acF(G) is the smallest integer k such that G is F‐avoiding k‐colorable. In this paper, we will give a complete answer to the following question: for which graph F, does there exist a constant C, depending only on F, such that acF(G) ⩽ C for any graph G? For those graphs F with unbounded avoiding chromatic number, upper bounds for acF(G) in terms of various invariants of G are also given. Particularly, we prove that \documentclass{article}\footskip=0pc\pagestyle{empty}\begin{document}${{ac}}_{{{F}}}({{G}})\le {{2}}\lceil\sqrt{{{n}}}\rceil+{{1}}$\end{document}, where n is the order of G and F is not Kk or \documentclass{article}\footskip=0pc\pagestyle{empty}\begin{document}$\overline{{{K}}_{{{k}}}}$\end{document}. © 2009 Wiley Periodicals, Inc. J Graph Theory 63: 300–310, 2010
Walter Miles, Pop Warner, B. C. Graves, and the psychology of football
Authors: Baugh Frank G. , Benjamin Jr. Ludy T. 
Published: July 2010

AbstractIn 1926–1927, a graduate student, B. C. Graves, working with Stanford University psychologist Walter Miles and legendary football coach Pop Warner, conducted an investigation of variations in signal calling as they affected the charging times of football players. The study was one of two that involved Miles and the ingenious multiple chronograph that he had invented to time the reactions of seven players simultaneously. These studies represented a brief digression in the career of Miles, who certainly was no sport psychologist. They tell of an interesting collaboration between scientist and coaches that produced one of the richest studies in sport psychology in the first half of the twentieth century. © 2006 Wiley Periodicals, Inc.
A survey of state medicaid policies on nursing home legal risk management programs
Authors: Kapp Marshall 
Published: July 2010

AbstractThis survey studied Medicaid policies on reimbursing long‐term care facilities for costs associated with legal risk management programs. Of the 45 responding jurisdictions, 26 allow risk management reimbursement (within allowable limits) as a general administrative expense, while 19 states do not reimburse for risk management costs. To the extent that (a) risk management can be demonstrated as cost/beneficial, and (b) that Medicaid policy influences institutional behavior, states should liberalize Medicaid reimbursement for risk management in long‐term care.
Chemical, radiochemical and biological studies of Sm and Ho complexes of H4dota analogues containing one methylphosphonic/phosphinic acid pendant arm
Authors: Lacerda Sara , Marques Fernanda , Campello Paula , Gano Lurdes , Kubíček Vojtěch , Hermann Petr , Santos Isabel 
Published: July 2010

AbstractThis work intends to investigate samarium and holmium complexes with a set of H4dota‐analogues bearing methylphosphonate/methylphosphinic acid pendant arms (H5do3ap, H5do3apPrA and H4do3apABn) as new bifunctional ligands for radiolanthanide targeted therapy. Radiolanthanide complexes of these ligands were prepared and evaluated and thermodynamic solution studies were also performed to get a better insight on the radiochemical results. The radiocomplexes were quantitatively prepared, are hydrophilic and negatively charged. They present a high in vitro and in vivo stability, a low plasma protein binding and a rapid clearance from the main organs with a high rate of whole body radioactivity excretion. Stability constants with Sm(III) and Ho(III) were determined by potentiometry and the values found are very high for all the ligands. Actually, they are similar to those of H4dota for the phosphinate analogues and even higher for the phosphonate ligand, being the constants similar to those with other lanthanide(III) ions. The effect of methylphosphorus acid pendant arms functionalization and the use of these ligands as bifunctional chelate agents are discussed. Copyright © 2009 John Wiley & Sons, Ltd.