bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics and Role of Apparent Diffusion Coefficient (ADC) Value in Musculoskeletal Soft Tissue Tumor
Authors: Elysanti Dwi Martadiani  , I Wayan Juli Sumadi  , I Wayan Gede Artawan Eka Putra  , Jonathan Andryanto  , Anak Agung Gede Agung Priyastana  , Felicia Nike  
Published: May 2024

Introduction: Musculoskeletal soft tissue tumors (STTs) consist of a group of malignant and benign tumors that present challenges in diagnosis and therapy. Adding diffusion-weighted imaging and apparent diffusion coefficient (DWI/ADC) ​​provides tissue characteristics that are different from those obtained by conventional MR techniques. Quantitative examination of the diffusion of water molecules in tissue is expressed as ADC value, which is expected to be more helpful in differentiating malignant and benign soft tissue masses. This study was carried out to determine the characteristics and role of ADC values ​​in musculoskeletal STTs.
Methods: This research was conducted retrospectively. Analysis was performed using MRI results of patients with musculoskeletal STTs who met the inclusion and exclusion criteria. Three regions of interest (ROI) were assessed in the tumor area with the strongest contrast enhancement for DWI mapping, ADC, and ROI ADC value placement. An Independent T-test test was performed to determine the mean difference of ADC in each tumor category. Receiver Operating Characteristics (ROC) were generated to find the optimal cut-off value. Then, a diagnostic test was carried out to determine the sensitivity, specificity, PPV, and NPV of the ADC value.
Results: There were 41 research subjects with musculoskeletal STTs with male predominance, in which 75.61% of cases were malignant. DWI/ADC showed that 78.05% of patients with musculoskeletal soft tissue tumors had restricted diffusion areas. In this study, the ADC cutoff value to differentiate benign and malignant musculoskeletal STT is 0,84 x 10-3mm2/s with 77.4% sensitivity and 90% specificity, 96% positive predictive value and 56.3% negative predictive value.
Conclusion: In differentiating malignant and benign musculoskeletal STTs, the ADC value provides fair sensitivity, very good specificity, good positive predictive value, and low negative predictive value.
Revealing the impact of losses on flexible pavement due to vehicle overloading
Authors: Miftahulkhair Muh , Arifin Muhammad Zainul , Sutikno Fauzul Rizal 
Published: May 2024

Pavement overload has become a significant concern in Indonesia due to its damaging effects on the pavement system, where most roads use flexible pavements. Meanwhile, overloading is also typical in other developing countries, causing everything from damage to accidents to the detriment of road users and operators. The current problem is that there is no definite knowledge of handling these overloaded vehicles, which has adverse effects. Therefore, this study aims to reveal the impact of losses caused by overloaded vehicles on flexible pavement.
This research uses vehicle traffic load data to examine actual conditions in the field, which are converted to axle load values for each vehicle and used to determine pavement condition using the truck factor approach, mechanistic-empirical design, pavement smoothness level, and the impact of overloading due to fuel consumption by vehicles on flexible pavement.
The results show that overloaded vehicles harm the flexible pavement. The increase in truck factor values for all vehicles in overloaded vehicles beyond the maximum allowable load results in more damage to the flexible pavement with an increase in truck factor values up to 83 %. The effect of overloading can be mitigated by increasing the thickness of the asphalt layer and the modulus of asphalt, so it is essential to pay attention to the quality of asphalt in anticipation of this overloading. To anticipate the overload phenomenon, it was found that the thickness of the asphalt overlay in the range of 170–205 mm could mitigate this detrimental effect. In addition, overloading affects the flexible pavement roughness and vehicle fuel consumption. Increased roughness and fuel consumption will increase road maintenance costs and affect driving comfort and safety. In addition, excessive fuel consumption can pollute the surrounding environment
Study of air deionization factors
Authors: Tykhenko Oksana , Glyva Valentyn , Levchenko Larysa , Burdeina Nataliia , Biruk Yana , Zozulya Sergey , Krasnianskyi Grygorii , Nikolaiev Kyrylo , Aznaurian Iryna , Zozulia Larysa 
Published: May 2024

The object of research is the dynamics in the concentration of air ions and suspended particles in atmospheric air and in supply-exhaust ventilation systems. An urgent task is to determine the factors and obtain quantitative data on the deionization of the atmospheric air that enters the environment where people live. Quantitative data on changes in the concentration of air ions depending on the time of day, temperature, and relative air humidity have been established. It was shown that even in the absence of significant man-made influence on the concentration of suspended particles, this indicator is at least 7000 cm-3. In the presence of wind, this indicator reaches 30000 cm-3 and higher. Measurement of the spectrum of suspended particles in the range of 0,3–6,0 μm showed that the predominant fraction is particles with sizes of about 3 μm. Studies have been conducted on changes in the concentrations of air ions in supply-exhaust ventilation systems. It was established that in the air duct made of galvanized iron, which has a length of 16 m, the concentration of negative air ions is reduced by 67 %, and positive by 78 %. Laboratory studies of air deionization in air ducts made of different materials were carried out. There is significant air deionization in metal and cardboard ducts while it is absent in wooden ducts. This indicates the electrical nature of deionization. A calculation method for forecasting the aero-ionic mode of premises, taking into account the factors of air deionization, is proposed. For rooms with supply-exhaust ventilation, a calculation apparatus is proposed taking into account the air exchange rate (the number of complete air changes per unit of time). The results make it possible to choose the required performance of artificial air ionization devices for normalizing the aero-ionic regimes in the premises
Determining rational parameters for the treatment of concentrated wastewater from etching site by using combined systems producing sediments of predefined composition
Authors: Yatskov Mykola , Korchyk Natalia , Budenkova Nadia , Mysina Oksana , Kyrylyuk Svitlana 
Published: May 2024

The object of this study is model solutions, spent sulfuric acid and chloride acid etching solutions, degreasing of metal products at enterprises.
The paper reports results of research on the possibility of obtaining sediments of predefined composition and reducing the consumption of chemical reagents in comparison with conventional cleaning schemes. The systematization of the elements of the technological scheme has been shown, which provides for the treatment of concentrated wastewater of the etching area in combined systems with obtaining sediments of predefined composition and is the basis for the implementation of resource-saving technology. Rational parameters were established for the state (рН=3‒4, Eh=+0.3‒+0.33 V, and rH2=16.3–19.38 V) and technological parameters (degree of iron extraction ψ=0.8, reagent consumption from the stoichiometric norm of B=0.8). Such parameters provide the proper conditions for the oxidation of organic compounds and their co-precipitation with insoluble iron hydroxy compounds (the maximum degree of extraction of organic impurities is 86 %). The formed precipitate corresponds to the FeOOH.nH2O composition, contains 2‒3 % of organic impurities, and is subject to burial. As a result of studies on the treatment of concentrated iron-containing wastewater, the obtained sediment is ready for further utilization by processing. The composition of this sediment corresponds to the natural mineral limonite FeOOH (Fe2O3.nH2O) and is formed at pH values from 3.5 to 7.5 with rH2 values from 26 V to 21 V and at technological regeneration parameters of pH=4.0–4.6; rH2 =23.34–32.25 V.
As a result of research into the deep purification of wastewater using a magnetic device, a suspension of sediment of ferromagnetic impurities (hydroxo compounds of iron) is obtained, which could be the basis for extraction or production of magnetically favorable dispersed material.
Profile of patients coming to the department of physical medicine and rehabilitation for locomotor disability certification: a 5-years observational study
Authors: Saha Sucheta , Gupt Sandeep K. , Mandal Suprakash 
Published: May 2024

Background: The persons with locomotor disability are eligible for various social welfare benefits from the Government under ‘The persons with disabilities (Equal opportunities, protection of rights and full participation) Act, 1995’ along with other causes of disabilities like blindness, hearing impairment etc. and recent enactment of the Rights of Persons with Disabilities (RPwD) Act, 2016. Understanding the utilization of services is crucial in enhancing assistance for individuals with certifiable disabilities. This study aimed to observe the clinico-demographic profile of patients coming to outpatient Department of Physical Medicine and Rehabilitations for locomotor disabilities certification and 5 years’ trend in the number of patients getting disability certificate.
Methods: This retrospective study was based on the data taken at time of disability certification in a multispecialty tertiary care government medical college in Northern India. All persons with locomotor disability who were issued disability certificate between 2014 and 2018 were included in the study.
Results: A total of 857 patients were issued disability certificates during the study period of 2014 to 2018. Among the 744 adult patients, only 149 (20%) were female. Most of them were urban residents. In locomotor disability, post-polio residual paralysis was the most common diagnosis encountered, followed by amputations and cerebral palsy. Most of the applicants were having a disability of 40-50%.
Conclusions: Awareness has to be generated about the disability benefits and disability certification. Utilisation of services by females should be encouraged. Robust data and literature need to be built up for prevention and management of locomotor disability.
Genetics of healthy aging and longevity
Authors: Pavlova E. V. , Erina A. M. , Rotar O. P. , Kostareva A. A. , Artomov M. N. , Konradi A. O. 
Published: May 2024

With the increase in life expectancy, there is an increase in the number of elderly people among the population, therefore, an important task for Russian health care is to ensure healthy aging. An examination of a group of centenarians can help in studying the factors and causes that contribute to a long life without development or with the later development of age-associated diseases. In many ways, the long life expectancy and better health of such people are genetically determined. At the same time, longevity, as a complex sign, is influenced by many genetic polymorphisms, often with a small individual effect. Identification of hereditary determinants and their effects on the mechanisms of aging is necessary to identify the foundations of healthy longevity and to find protector mechanisms and targets by which it is possible to prevent the occurrence or slow the progression of age-related diseases.The pathology of the cardiovascular system is the most significant of the diseases associated with aging, since it is the leading cause of mortality according to world statistics. Thus, cardiovascular aging is an important factor in determining a person’s life expectancy.This article examines the methodological aspects of studies involving centenarians, and also provides an overview of genes that affect both life expectancy and longevity, as well as the development and course of cardiovascular diseases.
PARÂMETROS DE QUALIDADE DE FILÉS DE PEIXE REFRIGERADOS E EMBALADOS SOB ATMOSFERA MODIFICADA
Authors: Henriques Lourenço Lúcia de Fátima , L. Sousa Consuelo Lúcia , Alves Barata Rafaela Cristina , Pereira da Silva Ana Caroline , Silva Santos Alberdan 
Published: May 2024

O uso de embalagens com atmosfera modificada em produtos de peixe facilita a manter o frescor, a segurança alimentar e aumentar a estabilidade comercial. O objetivo desta pesquisa foi avaliar os parâmetros de qualidade de produtos de filés de Macrodon ancylodon embalados em atmosferas modificadas armazenados a 2°C. As alterações foram acompanhadas através de avaliação sensorial, com aplicação do Método de Índice de Qualidade (QIM), determinação do pH, bases voláteis nitrogenadas totais (N-BVT), quantificação das aminas biogênicas, cor instrumental, composição gasosa das embalagens e análises microbiológicas. Foram elaborados produtos de filés de M. ancylodon embalados em atmosferas a vácuo (V) e com misturas gasosas de 50% CO2/50% N2 (G1), 60% CO2/40% N2 (G2) e 70% CO2/30% N2 (G3). A dissolução do CO2 na fase aquosa do músculo dos filés nos primeiros dias de estocagem foi influenciada pelo teor desse gás nas embalagens e ocasionou as principais alterações nos parâmetros de qualidade avaliados. As principais alterações sensoriais nos produtos G2 e G3 foram cor, o odor e as mudanças no aspecto do muco dos filés. Os efeitos bacteriostáticos do CO2 sobre o crescimento dos micro-organismos deteriorantes prolongaram a estabilidade comercial do produto G3. A perda de frescor dos produtos pelo aumento do pH, acúmulo de N-BVT e quantidade de putrescina e cadaverina também foi influenciado pela composição da mistura gasosa nos produtos. A correlação entre os parâmetros avaliados indicou que a estabilidade comercial dos produtos foi de 6 dias para G2 e 10 dias para G3.
Impact of tax regulation on the development of financial technology in Indonesia
Authors: Talahaturusun Jevan Andreas , Kohardinata Cliff 
Published: May 2024

Purpose — The objective of this study is to assess the influence of recently enacted tax legislation in May 2022 on the advancement of fintech in Indonesia.Method — The present study utilizes a quantitative approach to gather empirical data and conduct hypothesis testing. The population under investigation in this study consists of the total count of lender accounts across 34 provinces in Indonesia, classified according to quarterly periods. The methodology employed in this study involved selecting samples from 33 provinces. Data collection spanned from the second quarter to the fourth quarter of the 2021-2022 period, resulting in a total of 192 observations. The process of hypothesis testing was carried out using multiple regression analysis.Result — The research findings suggest that implementing fintech taxes significantly impacts the number of lender accounts in the following year. This implies that introducing taxes on fintech has a substantial influence on the lending sector, potentially leading to changes in the availability of accounts for borrowers and lenders in the year following the tax adoption.Contribution — The contribution of this study based on its novelty is that it provides unique insights into the consequences of the recently enacted fintech taxes, which took effect on May 1, 2022. Before this research, no other investigations had explored this specific topic, making this study the first of its kind to shed light on the implications of the regulatory changes within the fintech industry.
Factors Influence MSME’s Switching Behavior in Digital Marketing Channel: Evidence from Indonesia
Authors: Agustina Tri Siwi , Suwardianto Rico Adi Suwardianto , Jamali Muhebullah 
Published: May 2024

In realizing digital-based services and the application of people's economy, the Surabaya, Indonesia. The government has launched a website called E-Peken. It is hoped that the presence of digital marketing infrastructure can help MSME actors increase their business potential by expanding the marketing reach of their superior products. This study aims to determine the desire to switch to e-commerce regarding the failure of e-commerce services and the experience of using the E-Peken website. The research method used was quantitative with data collection through observation and questionnaires on 346 MSMEs in Surabaya City who were recorded as users of the E-Peken website. The results obtained show that the failure of e-commerce services has proven to affect switching intentions; usage experience is proven to affect switching intentions and switching intentions are proven to affect switching behavior from E-Peken to other e-commerce. In this manner, it is suggested that assist investigation include mediating or moderating variables. Managerial suggestions that can be submitted to the Surabaya Government as the E-Peken site service provider are to make strides in administrations on a progressing premise and continuously react to the desires of MSME’s players as users.
ApoM maintains cellular homeostasis between mitophagy and apoptosis by affecting the stability of Nnt mRNA through the Zic3-ApoM-Elavl2-Nnt axis during neural tube closure
Authors: Yuan ZhengWei , Liu Qing , Liu Dan , Wei Xiaowei , Ma Wei , Gu Hui , Jia Shanshan , He yiwen , Luo Wenting , Cao Songying , Wang Yuejiao , Yang Zhonghua , Wu Anhua 
Published: May 2024

Abstract

Research on the aetiology of neural tube defects (NTDs) has made progress in recent years. However, the molecular mechanism of apolipoproteins underlying NTDs development remains unclear. This study aimed to investigate the function of apolipoprotein M (ApoM) in the pathogenesis of NTDs and its underlying mechanisms. We demonstrated that ApoM expression was reduced in the spinal cord samples of rat models and human fetuses with NTDs respectively. Specifically, lack of ApoM resulted in reduced cytosolic localisation of Elavl2 and caused Nnt mRNA degradation, which further led to impaired cell homeostasis by suppressing PINK1-PRKN-mediated mitophagy and promoting apoptosis and subsequent NTDs formation. Moreover, Zic3 directly interacted with the promoter of ApoM and activated its transcription. Lastly, intra-amniotic delivery of adenoviral recombinant Zic3 or ApoM could promote mitophagy and alleviate apoptosis in spinal cords of NTDs. Collectively, these findings highlight the important role of the Zic3-ApoM-Elavl2-Nnt axis in cellular homeostasis during neural tube development, thereby revealing an intracellular molecular regulatory mechanism of ApoM, providing a mechanistic basis for understanding embryonic neural development, and offering experimental evidence for potential therapeutic targets for NTDs.
Nonlinear System Identification and PID Control: A Combined Approach using Structure Selection and Particle Swarm Optimization
Authors: Nabavi Hossein 
Published: May 2024

Abstract

System identification is a crucial first step in controller design. It involves selecting an appropriate identification model and estimating the model's parameters. This paper proposes a PSO algorithm that balances global exploration and local exploitation to overcome these issues. PSO incorporates the differences between particles and takes feedback from particle memories to accurately reflect the search process. The paper also discusses the use of PSO for PID controller design, specifically for tuning the proportional gain (Kp), integral gain (Ki), and derivative gain (Kd) parameters. This paper aims to utilize PSO for both parameter identification and control of nonlinear systems. The effectiveness of the proposed method has been investigated on two nonlinear systems. The PID parameters obtained based on the proposed method and the genetic algorithm are compared, showing that the PSO-based method is superior in faster convergence, higher accuracy, improved dynamic characteristics, and optimization time.
Identification of the critical genes and signaling pathways in subcutaneous adipose tissue after bariatric surgery based on the GEO database
Authors: Han Chunjia , Wang Yu , Wang Hao , Zhang Rui , Wang Junfeng , Xia Yabin , Wang Wei , Xia Yu , Zhang Houtao , Huang He 
Published: May 2024

Abstract

This study aimed to explore potential biomarkers and mechanisms following bariatric surgery. Two gene expression profiles from the Gene Expression Omnibus (GEO) were analysed to identify differentially expressed genes (DEGs) in subcutaneous adipose tissue (AT) post-bariatric surgery. Subsequently, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene-Set Enrichment Analysis (GSEA), and Protein-Protein Interaction (PPI) network analyses were employed to identify hub genes and associated pathways. Among the DEGs, 29 genes were downregulated. Enrichment analysis revealed that the downregulated DEGs significantly participated in inflammatory responses. GSEA provided comprehensive evidence that most genes were enriched in pro-inflammatory pathways before surgery, while after surgery, most genes were enriched in metabolism. In the PPI network, five key genes, including TREM2, MNDA, HP, C5AR1, and S100A8, were identified, with most validated as highly expressed in obesity by the Attie Lab Diabetes and another dataset, GSE72158. Bariatric surgery induces a significant shift from an obesity-promoting inflammatory state to an anti-inflammatory state, accompanied by improvements in adipocyte metabolic function. This represents a key mechanism for the enhancement of adipose tissue function following bariatric surgery. This study deepens the understanding of the benefits of bariatric surgery and provides potential biomarkers or therapeutic targets.
Modeling the interaction of the rolling stock and the track in the emergency braking mode of a passenger train
Authors: Zhauyt Algazy , Solonenko Vladimir , Musayev Janat , Zhunisbekov Seitbek , Kaliyev Yerbol , Smailova Gulbarshyn , Bikhozhayeva Gulmira , Yussupova Saltanat 
Published: May 2024

Abstract

The Author analyze the transitional mode of movement of a passenger train caused by sudden braking by the driver. To study the possibility of derailment of passenger cars, a simulation model of the movement of a train consisting of a locomotive and twenty passenger cars was developed in the Universal Mechanism software environment, designed to study the dynamics and kinematics of mechanical systems, which include railway rolling stock. The developed model allows taking into account the longitudinal, transverse and vertical vibrations of all cars and locomotive. All bodies in the model are assumed to be absolutely rigid. The assumption of non-deformability of the bodies is based on the fact that the stiffness of the spring suspension and elastic connections is significantly less than the structural rigidity of the bogie frames and the bolster structure, and the frequency of elastic vibrations of these bodies is much higher than the frequency of their vibrations on the spring suspension. Passengers and cargo in a wagon are considered to be non-deformable and integral with the wagon body, similarly in the case of a locomotive body. Between the elements of the system, connections are involved that regulate certain relative movements of these elements.