bluuebunny/crossref_metadata_2025_split huggingface dataset:
Administration of mesenchymal stem cell derivate secretome causes lower levels of Matrix Metalloproteinase-13, Aggrecanase-2, and Interleukin-1β than hyaluronic acid in rabbit knee osteoarthritis
Authors: Dharmayuda Cokorda Gde Oka , Kawiyana I Ketut Siki , Bakta I Made , Astawa I Nyoman Mantik , Astawa Putu , Manuaba Ida Bagus Putra , Suyasa I Ketut , Subawa Anak Agung Ngurah , Suroto Heri , Maker Luh Putu Lin Indrayani 
Published: May 2024

Link of Video Abstract: https://youtu.be/XrtI29YbnTs

Background: Osteoarthritis (OA) is the most common form of arthritis, which cause pain and disability that can affect the quality of life. The inflammation in OA is chronic and characterized by the infiltration of immune cells and the secretion of cytokines. Previous OA treatment used hyaluronic acid intraarticular injection, but several studies show no satisfactory clinical outcome. This study aims to determine and compare the anti-inflammatory and anti-catabolism effects of stem cell-derived secretomes versus hyaluronic acid as the gold standard for the treatment of OA.
Methods: This research was conducted using an experimental randomized post-test-only control group design. According to veterinarians, the population in this study were local rabbits, aged 6-8 months, weighing > 1,500 grams, and healthy. Data were analyzed using SPSS version 22.0 for Windows.
Results: Twenty-two subjects were included in each treatment and control group. From the descriptive analysis, it was found that MMP-13 levels were 7.55 ± 0.23 (Treatment) (ng/mL) and 8.36 ± 1.04 (Control) (ng/mL), ADAMTS-5 levels were 0.83 ± 0.08 (Treatment) (ng/mL) and 1.14 ± 0.33 (Control) (ng/mL), and levels of IL-1β 23.0 5± 2.48 (Treatment) (ng/mL) and 26.81 ± 5.57 (Control) (ng/mL). From the inferential test, it was found that all research results were statistically significant (MMP-13= 0.81; p = 0.021; 95%CI = -1.48 – (-0.13)) (Agrekanase 2 = 0.32; p = 0.006; 95% CI = -0.53 – (-0.09)) (IL-1β = 3.76; p = 0.023; 95% CI = -7.59 – (-0.08)).
Conclusion: Administration of mesenchymal stem cell-derived secretomes resulted in significantly lower levels of MMP-13, Agrekanase 2, and IL-1β compared to administration of hyaluronic acid in rabbit knee osteoarthritis
Description of screen time and dry eye syndrome in medical students of UIN Alauddin Makassar
Authors: Rimayanti Ulfah , Yustika Gita , Jamaluddin Sri Rezki Wahdania 
Published: May 2024

Link of Video Abstract: https://youtu.be/-B5Z8H6e4o0

Background: During pandemic, the amount of screen time in individuals is tremendously expanding. Excessive screen time may result in eye blinks reduction, tears evaporation, and eventually dry eye syndrome (DES). This study aims to show the descriptions of the duration of screen time and dry eye symptoms in medical students during the pandemic.
Methods: This study uses a descriptive and cross-sectional methods. The subjects were students of The School of Medicine at UIN Alauddin Makassar, who were undergoing online learning. The data were collected through a questionnaire containing subjects' activities using gadgets per day and the Ocular Surface Disease Index (OSDI) to assess dry eye symptoms. Ophthalmological examinations for DES (blink rate, tear meniscus height, tear break-up time, Schirmer test) were also performed on the study subjects.
Results: Most of the subjects are female and 22 years old. The average screen time of the subjects was 17.7 hours per day. Two subjects (4.55%) had mild dry eye symptoms, 14 subjects (31.82%) had moderate dry eye symptoms, and 28 subjects (63.64%), had severe dry eye symptoms. This study also found that the average blink rate of the subjects was 11.36±7.45 times per minute, and the average TBUT value was 10.58±2.69 seconds. Schirmer 1 examination showed a value with a mean of 23.67±12.76 mm, and Schirmer 2 examination showed a value of 20.21±11.64 mm.
Conclusion: The average screen time of the subjects was 17.7 hours. Most subjects had severe dry eye symptoms (63.64%) and low blink rate (59.09%).
Progressive ovarian sertoli – leydig cell tumor: case report
Authors: Raynaldi Juanda , Hasanuddin  , Nainggolan Sarah Ika , Munizar  
Published: May 2024

Introduction: Ovarian Sertoli – Leydig Cell Tumor (SLCT) are one of sex cord tumor that has incidence rate less than 0,2% of all ovarian tumors. It occurs predominantly in second and third decades of lifetime. It has characteristics mostly low–grade malignant although poorly differentiated type may behave more aggressively. Clinical characterstic of ovarian SLCT usually hormonal changes, nevertheless in patients without hormonal changes, the manifestation of the disease consists of abdominal pain and abdominal enlargement, and palpable adnexal mass on physical diagnostic.
Case: a 52 years woman that has been undergo right salpingooforectomy 5 months prior with PA result shows poorly differentiated sertoli – leydig cell tumor, and refusing to chemotherapy. She came with chief complaint of abdominal enlargement since 3 months accompanied with lower abdominal pain 2 weeks prior. Ultrasound examination shows cystic ovarian neoplasm with solid part size 9 x 9 x 9 cm from left adnexa. Tumor markers that arise are Alpha–Fetoprotein (AFP) 52 ng/mL and Lactate Dehydrogenase (LDH) = 432 U/mL which correspond to sex cord tumor. She has undergone Laparotomy Total Abdominal Hysterectomy Left Salpingooforectomy and chemotherapy afterward.
Conclusion: Ovarian Sertoli – Leydig Cell Tumors (SLCT) are a rare sex cord ovarian tumor that may behave more aggressively as it poorly differentiated. It has manifestations of hormonal changes and also abdominal enlargement.
Effect of mini low carbohydrate diet and eating speed in obese adults on fasting blood glucose
Authors: Yaqiin Muhammad Aldhi Ainul , Lestari Anik , Sumardiyono  
Published: May 2024

Link of Video Abstract: https://youtu.be/FcVVr3DoiOs

Background: Obesity is an issue with public health that affects people worldwide and raises morbidity and mortality rates. In addition to dietary factors, non-nutritional factors like meal frequency and duration also contribute to the increased risk of obesity. This study aims to evaluate the duration of meals that will be compared between obese subjects who receive a mini low carbohydrate diet and those who do not.
Methods: Used a cross-sectional, quasi-experimental design in this study. Seven days of testing on 70 obese subjects who met the inclusion criteria for this study were conducted in November at the Palangka Raya city health center. Using a stopwatch to time the length of each meal in seconds and fasting blood glucose tests. Paired T-test and Independent Sample T-test are used in statistical analysis, while Wilcoxon and Mann-Whitney tests are used in the non-parametric analysis. Data were analyzed using SPSS version 20.0 for Windows.
Results: Blood glucose levels and eating speed did not correlate significantly in the mini low carbohydrate diet (M-LCD) group (p>0.05), but they correlated significantly in the control group (CG) (p<0.05). There was a significant difference in fasting blood glucose of the M-LCD and CG groups (p<0.05).
Conclusion: There was no correlation between meal speed and fasting glucose levels in the M-LCD group, but there was a significant difference between the M-LCD and CG groups' fasting blood glucose levels.
Mirror therapy combined with flashcards on the extremity function and stages of self-acceptance of stroke patients
Authors: Purba Maria Magdalena , Aden Christine , Kusfriyadi Mars Khendra 
Published: May 2024

Link of Video Abstract: https://youtu.be/u6GkzKfCplE

Background: Psychological changes such as body image are important factors that need to be considered to boost the positive sense of self-acceptance in stroke patients with hemiparesis. One measure that can be taken to minimize the incidence of disability, both physically or psychologically, in stroke patients is mirror therapy (mirror therapy combined with flashcards). This study aims to determine whether mirror therapy combined with flashcards can improve the upper limb muscle strength function and the stages of self-acceptance of stroke patients with hemiparesis.
Methods: This study was quantitative, with an experimental research design. The design used was a quasi-experiment with a pre-test-posttest control group design involving 60 respondents with consecutive sampling techniques for 5 months in the Nusa Indah Ward of the Dr. Doris Sylvanus Palangkaraya General Hospital. Upper extremity/arm muscle strength was measured using the muscle strength scale from the Medical Research Council, while self-acceptance stages were measured using a stage questionnaire adapted from Kubler Ross. Data were analyzed using SPSS version 20.0 for Windows.
Results: Our results showed there was a significant increase in the mean value of muscle strength and self-acceptance stages of the treatment group from the control group (p<0.05). The results of the Mancova test showed that gender affects the intervention given (p<0.05).
Conclusion: Our study provided information for nurses in nursing care to stroke patients with hemiparesis on the upper arm and motivation to improve the patient's self-acceptance stages.
Efficacy of topical medroxyprogesterone acetate 1 % and topical doxycycline reduce MMP-9 and TGF-β1 expression as corneal ulceration due to alkali burn: literature review
Authors: Juwita Anindita , Agustini Lukisiari , Loebis Rozalina , Zuhria Ismi , Ridholia  , Ardianto Chrismawan 
Published: May 2024

Link of Video Abstract: https://youtu.be/rypOUr0MPxA

Corneal alkali burn is a typical ophthalmology emergency which requires immediate management and treatment. Alongside conventional treatment, medroxyprogesterone and doxycycline are considered potent add-on treatments. This literature review was conducted to determine their impact towards corneal wound healing after an alkali burn. It was proven from studies extracted from literature searching among various databases that medroxyprogesterone and doxycycline proven to reduce the inflammatory condition of corneal wounds after alkali trauma. In addition, they are subjected to reduce matrix metalloproteinase (MMP-9) and transforming growth factor (TGF-β1), which are abundant and over-expressed in a corneal wound and could cause excessive inflammation and neovascularization of cornea, which results in hazy and disintegrated corneal tissue after recovery. Therefore, the usage of topical medroxyprogesterone acetate 1% and doxycycline is proven beneficial for patients with corneal wounds after being exposed to alkali burns.
A comparison of otoacoustic emissions examination results as early hearing screening in normal and infants at risk of hearing loss
Authors: Falerina Rosa , Nugroho Puguh Setyo , Purnami Nyilo , Salsabila Fatimah Azizah 
Published: May 2024

Link of Video Abstract: https://youtu.be/fvbkSDEVY3Q

Background: A child's ability to speak must be supported by a good hearing function. With early detection of hearing loss, it is hoped that intervention can be made promptly, thus improving the quality of life (QOL) of children with hearing loss at birth. The purpose of this study was to compare the otoacoustic emissions (OAE) examination results in infants with and without risk.
Method: The OAE examination was conducted on 60 newborns with and without risk factors in the nursery room and ORL-HNS outpatient unit. For all the newborns aged > 24 hours and before being discharged from the hospital with inclusion criteria, the OAE examinations were performed and repeated when they were 1 and 2 months old. Furthermore, the comparison of OAE results on newborns with and without risk factors aged > 24 hours, 1 month, and 2 months were statistically analyzed.
Results: A Friedman statistical analysis test was then conducted to examine the correlation between the results of the first, second, and third OAE examinations. The first, second, and third OAE examination results of newborns with and without risk factors were compared, significant differences were found with a p-value of 0.0111 (p < 0.05).
Conclusion: The newborn hearing screening using OAE should be performed for all newborns (Universal Newborn Hearing Screening) and serially to minimize the number of higher referrals to health facilities to improve an individual's quality of life in the future.
Managing and diagnosing fibromyalgia in psychiatry
Authors: Arizona Popy , Setiawati Yunias 
Published: May 2024

Fibromyalgia (FM) is a chronic pain syndrome that is quite common. This syndrome is often not diagnosed correctly because the symptoms are heterogeneous and often overlap with other diseases. In 2010, the American College of Rheumatology (ACR) established a feasible diagnostic criterion for FM then in 2016 ACR revised FM criteria. The clinical problems of FM vary widely and depend on the individual's management, depending on the severity and severity of the complexity, the degree of damage that occurs and the comorbidities in the psychiatric field that most commonly occur in anxiety disorders and depression.
The relationship of motivation and interest with a healthy lifestyle based on self-regulation of motivation theory
Authors: Khamida  , Yusuf Ah , Fitryasari Rizki , Susi Hartati Husnia , Budury Syiddatul , Setiawan Arif Helmi 
Published: May 2024

Introduction: Clean and healthy living behavior or healthy lifestyle is the implementation of awareness and experience of a group that aims to maintain and improve health status. However, students in several Islamic boarding schools need to implement this properly due to a lack of motivation and interest. In addition to the pattern of clean and healthy living behavior in Islamic boarding schools, the reason they get related to past interests is still low. Thus, this study aims to determine the relationship between cause and claim in a healthy lifestyle for students.
Methods: The design of this research was cross-sectional. The research sample was all students of class VII at Pesantren Al Hidayah Sidoarjo, with 147 respondents using a simple random sampling technique. The independent variable was motivation and interest. The dependent variable was a healthy lifestyle. The research instrument uses a questionnaire that has been tested for validity and reliability. Data were analyzed by the Spearman rank test with a significance level of = 0.05.
Results: The results of the study were obtained as follows. Based on the characteristics of the sample, it was found that the majority were aged 12 to 15 years (67.3%), while the remaining 32.7% were aged 15 to 18 years. According to gender, most of the respondents were male (51.7%). The results showed a correlation between motivation and interest in a quality, healthy lifestyle (p-value = 0.001). A strong correlation was found between motivation and a healthy lifestyle (r=0.909 and the interest variable p-value = 0.000, so it can be concluded that both have a significant relationship with a healthy lifestyle.
Conclusion: The higher the motivation and interest, the better the clean and healthy behavior of students. The study’s results can be used as a reference so that the caregivers of the Islamic boarding school provide facilities and infrastructure that support the realization of a clean and healthy life behavior for students.
Correlation between stress and insomnia with learning outcomes: a cross sectional study
Authors: Hatmanti Nety Mawarda , Zurmida Ulfa Mazuzin , Septianingrum Yurike , Purwanti Nunik , Maimunah Siti 
Published: May 2024

Introduction: Stress can happen anywhere and to anyone. Stress that cannot be controlled causes difficulty in concentration, difficulty remembering lessons, difficulty understanding lessons, frequent dizziness, feeling sluggish, weak and insomnia. Thus, this study aimed to determine the relationship between stress levels and insomnia with student achievement at Pondok Pesantren Tebuireng Jombang.
Method: The research design was correlational analytic using a retrospective research approach—the population of all students in class X-XII at Pondok Tebu Ireng Jombang in February 2022. From 620 children, 243 students were taken by stratified simple random sampling. The independent variables were the level of stress and insomnia, and the dependent variable was the learning achievement. Data collection in this study used a questionnaire (DASS), an insomnia rating scale questionnaire, and learning achievement with a learning report book. The data were analyzed by the Spearman Rho test in SPSS 25.
Results: Based on a characteristic sample from 243 respondents, it was found that most of them were male (59.26%), by the age were 17 years old (34.16%). Several students experienced stress. Luckily the highest stress level they experienced was moderate (31.3%), and the highest grade of insomnia they experienced was moderate. The correlation analysis of stress level and learning achievement obtained r=-0.425 and p=0.001. It indicated a significant correlation between stress level and learning achievement, with a moderate correlation. A similar finding was also found in the correlation of insomnia with learning achievement (p=0.001; r=-0.482)
Conclusion: In this study, almost all respondents have a mild stress level and sufficient achievement. Meanwhile, nearly all respondents who experienced mild insomnia had acceptable learning achievement. Both variables correlated with the level of achievement of students. Thus, maintaining stress levels and sleep time among students at a normal level is needed.
Non-motor seizure diagnosed after mild traumatic brain injury: a case report
Authors: Windriya Drestha Pratita , Wiryawan Reryd Arindany , Islamiyah Wardah Rahmatul , Machin Abdulloh 
Published: May 2024

Introduction: In 10% of head injury cases, nonmotor seizures were detected by electroencephalography (EEG) performed in the acute phase. Nonmotor seizures are often not diagnosed at the start of treatment because the symptoms are often not recognized by the patient's family or doctor. The incidence of seizures in patients with minor head injuries is very low. From the literature, it was found that the type and severity of the head injury is a significant factors in the incidence of post-traumatic seizure. Thus, in this article, we report a case of nonmotor seizures in a patient after a minor head injury.
Case description: An Indonesian female, 53 years old, complained of sudden silence when speaking after 4 days earlier, she fell and hit her head on the right side. There was no loss of consciousness, headache, vomiting or limb weakness. Complaints of motor seizures and a history of previous seizures were denied. There were no cranium defects, hematomas, or open wounds on examination. The results of laboratory tests and non-contrast head CT scans were expected. On electroencephalography (EEG) examination, epileptiform waves were found in the left temporal region. The patient was given anti-seizure drugs, and complaints improved within 2 days of therapy. It is crucial to carry out an EEG examination in the acute phase of a head injury to exclude the possibility of nonmotor seizures and brain dysfunction, which will be at risk of causing seizures later in life after trauma. Conclusion: EEG examination in the acute phase of head injury is used to exclude the possibility of nonmotor seizures and brain dysfunction, which will be at risk of causing seizures later in life after trauma.
Student perception of nurse communication learning with patients according to pancasila values
Authors: Shodiq M. , Hasina Siti Nur , Maimunah Siti , Afandi Mujad Didien 
Published: May 2024

Introduction: Pancasila is the ideology of the state and is a collection or set of values that are believed to be true by the government and the people of Indonesia. Perception is a person's ability to organize an observation. One of students perception is regarding nurses communication. The research aims are to describe students perception regarding nurses communication between nurses and patients according values of Pancasila.
Method: A design of descriptive study was used with mixed methods approach that combines or associates qualitative and quantitative. Descriptive research was to describe the data obtained from students' perceptions of learning communication between nurses and patients according to the values of Pancasila.
Results: There were 52 nursing students involved in this study. We showed that almost all of the students' perceptions strongly agreed with the application of Pancasila values in nurse-patient communication
Conclusion: Nurse-patient communication has implemented Pancasila values in serving patients in hospitals with evidence that stands out the value of strongly agree and agree answers.
Effects of misoprostol as a drug to induce abortion in the second trimester: a forensic case report
Authors: Syamsun Arfi , Sutjianto Jaury , Rahma Elita , Masadah Rina , Cangara Husni , Nelwan Berti Julian 
Published: May 2024

Link of Video Abstract: https://youtu.be/rMasD6pMero

Introduction: Induced abortion with misoprostol in the second trimester can be harmful to both mother and fetus, especially when the abortion is self-administered with telemedicine. Considering the effects that might occur in misoprostol usage to induce abortion, we ought to present our experience through this article regarding the effect of misoprostol as a drug to induce abortion in the second trimester.
Case Description: In the first case, a 30-year-old woman engaged in a self-induced abortion at her residence subsequent to consulting with medical personnel at a local community health centre, where she received oral and vaginal administration of misoprostol. Unfortunately, complications arose as the mother experienced post-abortion bleeding, which necessitated a curative procedure. Tragically, the fetus perished in utero due to asphyxia. In the second case, a 20-year-old woman opted to undergo a self-induced abortion at home following consultation and the acquisition of misoprostol from an online source. In cases where fetuses experience asphyxia within the womb, they are unable to exit the uterus spontaneously. Consequently, the mother experienced post-abortion bleeding as an aftermath of the procedure.
Conclusions: Misoprostol-induced abortion in the second trimester causes maternal bleeding and intrauterine fetal mortality. Medical staff should handle abortions professionally, considering into account both the patient's health and the legal considerations.