bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quichottisme et méthodes chez Descartes et Sorel
Authors: Falantin Flavien 
Published: May 2024

Résumé
Antonomase forgée à l’aide du célèbre personnage cervantin, le quichottisme représente cette distorsion du réel survenue après une immersion romanesque immodérée. Avant l’heure, Don Quichotte promeut simultanément l’anti-cogito, l’anti-pensée et l’anti-héros. Autrement dit, il est l’incarnation d’un modèle à abattre pour les philosophes du XVIIe siècle. Le présent article propose donc de reprendre la dénonciation du roman espagnol, lancée conjointement par Descartes et Sorel, en montrant leur double perspective critique. La confrontation de leurs méthodes respectives, établies dans le but d’extraire le lecteur des limbes de la fiction, laisse entrevoir un élément épistémologique commun : la présence d’une triple instance narrative. Dès lors, une navigation discursive dangereuse s’amorce entre la Scylla sorélienne, visant à guérir l’amateur de roman parodique par son jumeau satirique l’anti-roman, et la Charybde cartésienne, substituant à l’immersion fictionnelle, créatrice de naïveté, un pacte de lecture qui lui serait soi-disant antithétique. Ce dialogue entre les deux auteurs permet de développer plus avant l’hypothèse de John Lyons sur la récurrence du mot extravagance chez Descartes, qui semble viser Sorel. Mais construit au contact des romanciers qu’il fustige, le Discours de la méthode ne devient-il pas, à son tour, un anti-roman comme les autres ?
Introduction
Authors: Anusha Chandana , Omer Ayesha , Shankar Devika 
Published: May 2024

Abstract
Massive modern port projects across the Atlantic, Pacific, and Indian Ocean in the twenty-first century are where anxieties about the global economy, state sovereignty, and climate change converge. Many of these port projects are agents of a country's geopolitical aspirations. Port constructions engineer rigid boundaries between land and sea, rendering coastlines vulnerable to sea-level rise. Port operations generate effluents from imports like coal and oil that contaminate coastal environments, with devastating consequences for ecologies. They generate debates about the future of the world, where futures of economic growth through technological revolutions in shipping and logistics clash with ecological collapse caused by such mega-infrastructures on already vulnerable coastlines. This interdisciplinary special section, “Port Environments in South Asia,” enters such debates by focusing on ports in South Asia. The South Asian coastline, after all, is today a site of aggressive port development even as scientists project it to be an early victim of the rising sea. “Port environments” allows contributors to move from intimate interactions with local ecologies to the underlying political and legal debates shaping the making and remaking of ports and coasts. As this introduction details, “Port Environments in South Asia” probes the cultural and political desires and discontents entangled in port building and seeks to nurture alternative ways of inhabiting the coastline.
40 years of homeodomain transcription factors in the Drosophila nervous system
Authors: Doe Chris Q. , Thor Stefan 
Published: May 2024

ABSTRACT
Drosophila nervous system development progresses through a series of well-characterized steps in which homeodomain transcription factors (HDTFs) play key roles during most, if not all, phases. Strikingly, although some HDTFs have only one role, many others are involved in multiple steps of the developmental process. Most Drosophila HDTFs engaged in nervous system development are conserved in vertebrates and often play similar roles during vertebrate development. In this Spotlight, we focus on the role of HDTFs during embryogenesis, where they were first characterized.
Morphological variation in the Cerralvo Island pocket mouse Chaetodipus siccus from the Baja California Peninsula, México
Authors: Álvarez-Castañeda Sergio Ticul 
Published: May 2024

Chaetodipus siccus is a microendemic species with a restricted distribution and two geographically isolated populations, one on Cerralvo Island and its counterpart on the Baja California Sur peninsula, each associated with dissimilar environmental conditions. The hypothesis to test is that each population is adapted to its distinct environment and has its own evolutionary trend that can be used to differentiate them. The analysis of the skull shows that each population has a differential development of the region associated with chewing muscles. The statistical analyses of the Procrustes (shape) and Mahalanobis (size) distances confirm these differences statistically (P < 0.05). The set of differences in skull shape associated with the chewing muscles, craniodental measurements, external morphological traits, genetic isolation, and association with a different environment support the hypothesis that each population has its own evolutionary tendency.
Community of medium and large-sized mammals and functional diversity in a tropical rainforest of Southern México under different degrees of human pressure
Authors: Arroyo-Gerala Paulina , Towns Valeria , Medellín Rodrigo A. , de la Maza Javier , de la Torre J. Antonio 
Published: May 2024

Functional diversity quantifies the distribution and range of functional traits of species that influence ecosystem processes. We evaluated the functional diversity of the medium and large-sized mammals in a tropical rainforest in Southern Mexico to determine which landscape characteristics associated with human activities affected the composition of mammal functional diversity and functional group abundances. We used camera-traps to document the diversity and composition of medium and large-sized mammals at four sites with different levels of protection and management. We estimated species richness, diversity, and functional diversity for each site, and compared these indices between sites to understand the effects of biodiversity loss in ecosystem dynamics and to detect ecological patterns driven by human perturbation. The density of human settlements was the main covariate related to low species richness and low abundance of large mammals with specialized diets and low population densities. Poaching and other human activities in forested areas near human settlements might have caused large herbivore and specialized carnivore populations to decrease, and populations of medium-sized rodent species to increase. Our results indicated that human perturbation in forested areas had also an impact at the functional level reducing the abundance of some functional groups, and this might have negative consequences for tropical rainforest functions in the long term. Effective management actions should be implemented in Protected Areas with a high density of human settlements nearby to prevent the decline of mammals’ functional groups and negative consequences for tropical rain forests’ ecological functions.
Content Validity Testing of the Community Life Engagement Guideposts Fidelity Scale
Authors: Lyons Oliver , Sulewski Jennifer , Kwan Ngai 
Published: May 2024

Abstract
The current study sought to address the lack of tools for defining and measuring the quality of day services and supports through the development of a statistically valid tool—the Community Life Engagement (CLE) Guideposts Fidelity Scale (GFS). A Delphi panel composed of 27 experts in the field of CLE reviewed and validated statements on the GFS. This review resulted in a 72-statement scale. All 72 statements demonstrate content validity ratio of .5 or higher. Findings showed that the panel eliminated statements that took focus away from the individual, statements that promoted specific practices, and statements that relied too heavily on the job-readiness aspects of CLE. Implications for the field as well as further testing and refinement of the GFS are also discussed.
Association between body mass index and prevalence of bacterial vaginosis: Results from the NHANES 2001–2004 study
Authors: Qi Jie , Han Hua , Li Xinjun , Ren Yanan 
Published: May 2024

Background
The impact of bacterial vaginosis on women’s health is an increasing concern; however, the effect of the obesity index on bacterial vaginosis is controversial. We investigated the association between body mass index and bacterial vaginosis in women in the United States.

Methods
This was a cross-sectional study which obtained the data from the National Health and Nutrition Examination Survey from 2001 to 2004, in which weighted multivariate regression and logistic regression analyses were performed to explore the independent relationship between body mass index and bacterial vaginosis. Subgroup analyses and smoothed curve fitting were also performed.

Results
A total of 5,428 participants were enrolled, and the findings show that the participants with higher body mass index tended to have a higher incidence of bacterial vaginosis. In the fully adjusted model, a positive association between bacterial vaginosis and body mass index was observed (Odd’s ratio = 1.03, 95% Confidence interval, 1.01–1.04). The subgroup analysis showed that this positive association was significant in non-Hispanic White individuals (Odd’s ratio = 1.0327, 95% Confidence interval, 1.0163, 1.0493).

Conclusion
Increased bacterial vaginosis positivity may be associated with an increased body mass index.
Mediating roles of perceived stigma and mental health literacy in the relationship between school climate and help-seeking behavior in Indonesian adolescents
Authors: Setia Lesmana Mohammad Hendra , Chung Min-Huey 
Published: May 2024

Objective
This study aimed to investigate whether perceived stigma and mental health literacy play mediating roles in the correlation between school climate and help-seeking behavior in Indonesian adolescents.

Methods
We used cross-sectional study design that recruited 760 Indonesian adolescents of age 16–19 years. We used convenience sampling from July to September 2019. Bivariate analysis was used to investigate the association of demographic characteristics with help-seeking behavior. Mediation analysis was employed to explore the mediating roles of mental health literacy and perceived stigma on the relationship between school climate and help-seeking behavior.

Results
Findings indicated that ethnicity, family income, and father’s educational level were significantly associated (p < 0.05) with help-seeking behavior in Indonesian adolescents. Furthermore, perceived stigma and mental health literacy sequentially showed partial mediating roles in the relationship between school climate and help-seeking behavior (indirect effect: 0.004; 95% CI: 0.001, 0.010). Our mediating model indicated that a high level of school climate was associated with low perceived stigma (b = −0.11, p < 0.001) and high mental health literacy (b = 0.28, p < 0.001) and higher help-seeking behavior (b = 0.14, p < 0.001).

Conclusion
Our study discovered novel insight of help-seeking behavior mechanism among adolescent by serial mediation test. Supportive school climate is necessary to achieve adequate help-seeking behavior. In addition, taking into account of student’s perceived stigma and mental health literacy in promoting help-seeking behavior is also important.
Assessing the influence of the health system on access to cervical cancer prevention, screening, and treatment services at public health centers in Addis Ababa, Ethiopia
Authors: Hussein Kemal , Kokwaro Gilbert , Wafula Francis , Kassie Getnet Mitike 
Published: May 2024

Background
Cervical cancer is the second leading cause of cancer death among Ethiopian women. This study aimed to assess the influence of the health system on access to cervical cancer prevention, screening, and treatment services at public health centers in Addis Ababa, Ethiopia.

Methods
This study used a cross-sectional survey design and collected data from 51 randomly selected public health centers in Addis Ababa. Open Data Kit was used to administer a semi-structured questionnaire on Android tablets, and SPSS version 26 was used to analyze the descriptive data.

Results
In the study conducted at 51 health centers, cervical cancer prevention and control services achieved 61% HPV vaccination for girls, 79% for cervical cancer awareness messages, 80% for precancer lesion treatment, and 71% for cervical screening of women. All health centers were performing cervical screening mostly through visual inspection with acetic acid due to the inconsistent availability of HPV DNA tests and the lack of Pap smear tests. In 94% of health centers, adequate human resources were available. However, only 78% of nurses, 75% of midwives, 35% of health officers, and 49% of health extension workers received cervical cancer training in the 24 months preceding the study. Women had provider choices in only 65% of health centers, and 86% of the centers lacked electronic health records. In 41% of the health centers, the waiting time was 30 minutes or longer. About 88% and 90% of the facilities lacked audio and video cervical cancer messages, respectively.

Conclusion
This study revealed that the annual cervical cancer screening achievement was on track to fulfill the WHO’s 90-70-90 targets by 2030. We recommend that decision-makers prioritize increasing HPV vaccination rates, enhancing messaging, reducing wait times, and implementing electronic health records to improve access to cervical cancer services in Addis Ababa.
Poisoning cases and their management in Amhara National Regional State, Ethiopia: Hospital-based prospective study
Authors: Asrie Assefa Belay , Atnafie Seyfe Asrade , Getahun Kefyalew Ayalew , Birru Eshetie Melese , Mekonnen Gashaw Binega , Alemayehu Geta Asrade , Endehabtu Berhanu Fikadie , Badi Marta Berta , Adinew Getinet Mequanint 
Published: May 2024

Background
Poisoning is a significant public health problem globally. Ethiopia is a low-income country undergoing technological and social change that may increase access to drugs and chemicals, potentially increasing the incidence of poisoning. This study describes the epidemiology of hospital admissions due to poisoning in a region of Ethiopia.

Methods
An institution based prospective observational study was employed, as a study design, in selected hospitals of the region from January to December 2018.

Results
Of 442 poisoning cases, 78 (17.6%) died. Almost all poisoning cases were intentional self-poisonings. The most frequent poisonings were organophosphate compounds, 145 (32.8%), and metal phosphides (majorly aluminum phosphide), 115 (26.0%). The ingested poison was most frequently accessed from the patients’ homes, 243 (55.0%), followed by purchases from local shops, 159 (36%). The median duration of admission was 24 hours. Of all the cases, 23 (5.2%) were admitted to intensive care units (ICU) requiring mechanical ventilation. Most of the cases admitted to the ICU were aluminum phosphide-poisoned patients. The majority of deaths (43 of 78) were due to metal phosphides. From the multivariate logistic regression analysis, altered level of consciousness on hospital arrival, metal phosphide poisoning, and no laboratory result as a part of the diagnosis process or investigation of the extent of toxicity were found to be significantly associated with the likelihood of poor treatment outcome.

Conclusion
The majority of the poisoning cases were females. The most common reasons for the intent of self-poisoning were dispute-related, mainly family disharmonies, followed by psychiatric conditions. The poisoning agents were mostly obtained from households. Organophosphate compounds and metal phosphides were the first and the second most frequently encountered poisoning agents, respectively, and it was noted that the later ones were responsible for most of the fatal cases. Of the pharmacologic interventions, atropine was the only agent regarded as an antidote. The most commonly employed agent for supportive treatment was cimetidine followed by maintenance fluids, while gastric lavage was the only GI decontamination method used among others. The fatality rate of poisoning in this study was found to be much higher than in other similar studies. Impaired consciousness upon hospital arrival, metal phosphide poisoning, and no involvement of laboratory investigation were found to significantly associate with the likelihood of death. Generally, the results dictate the need for the design and implementation of strategies to create awareness, prevent, and manage poisoning incidences in the community.
Documenting the implementation processes and effects of the data use initiatives in primary health care settings in Tanzania: A before-after mixed methods study protocol
Authors: Kalolo Albino , Kesale Anosisye M. , Anasel Mackfallen , Kapologwe Ntuli A. , Jaribu Jennie , Mujaya Stella , Kengia James T. 
Published: May 2024

Background
The use of data in decision making and planning in primary health care settings is critical for improving efficiency and health outcomes for patients and communities. Implementation research can be used to fully understand the effects, context, challenges, and facilitators of data use, as well as how to scale up data use interventions. However, in the context of low resource settings, little is known about how implementation research can be employed to assess the implementation and impact of data use interventions.

Methods
We will conduct a hybrid type 2 effectiveness-implementation study employing a mixed method controlled before and after design to measure the effects of data use interventions while simultaneously understanding the implementation of those initiatives. The controlled before and after entails measurement of the effects of the interventions at baseline and end line in a matched intervention and control health facilities using structured questionnaire to health workers (n = 440) and existing patients (n = 422) while also extracting selected health outcome variable from routine data in all participating health facilities (n = 80). The mixed methods component entails measuring the implementation outcomes (adoption, acceptability, fidelity and maintenance) and their moderators entails the integration of both quantitative and qualitative data collection, analysis, and interpretation (i.e. mixed methods) approach by using a structured questionnaire to implementers (health workers and managers) (n = 400). Experiential dimensions of implementation processes and moderators will be explored using qualitative interviews. Guided by implementation research theories and frameworks, a theory of change (TOC) is developed first to guide the evaluation of implementation processes and effects of the interventions. Descriptive and inferential statistics will be employed to analyze quantitative data whereas thematic analysis approach will be employed for qualitative data.

Discussion
This study is one of the first to test the simultaneous measurement of effects and implementation processes of data use interventions in the primary health care settings. Findings will support efforts to improve quality of services by optimizing scale up and sustainability of the data use initiatives in primary health care settings.
IGF2BP3 regulates the expression of RRM2 and promotes the progression of rheumatoid arthritis via RRM2/Akt/MMP-9 pathway
Authors: Ban Zhaonan , Li Zhengjiang , Xing Shuxing , Ye Yongjie 
Published: May 2024

Background
Rheumatoid arthritis (RA) is a common inflammatory and autoimmune disease. Ribonucleotide Reductase Regulatory Subunit M2 (RRM2) is a crucial and a rate-limiting enzyme responsible for deoxynucleotide triphosphate(dNTP) production. We have found a high expression level of RRM2 in patients with RA, but the molecular mechanism of its action remains unclear.

Methods
We analyzed the expression of hub genes in RA using GSE77298 datasets downloaded from Gene Expression Omnibus database. RRM2 and insulin-like growth factor-2 messenger ribonucleic acid (mRNA)-binding protein 3 (IGF2BP3) gene knockdown was achieved by infection with lentiviruses. The expression of RRM2, IGF2BP3, matrix metalloproteinase (MMP)-1, and MMP-9 were detected via western blotting assay. Cell viability was detected via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. MeRIP-qRT-PCR was performed to test the interaction of IGF2BP3 and RRM2 mRNA via m6A modification. Cell proliferation was determined by clone formation assay. Migration and invasion assays were performed using transwell Boyden chamber.

Results
RRM2 and IGF2BP3 were highly expressed in clinical specimens and tumor necrosis factor alpha (TNF-α) and interleukin (IL)-1β-stimulated synovial cells. RRM2 and IGF2BP3 knockdown inhibited the proliferation, migration, and invasion of MH7A cells. The inhibitory effects of IGF2BP3 knockdown were effectively reversed by simultaneously overexpressing RRM2 in MH7A cells. By analyzing N6-methyladenosine (m6A)2Target database, five m6A regulatory target binding sites for IGF2BP3 were identified in RRM2 mRNA, suggesting a direct relationship between IGF2BP3 and RRM2 mRNA. Additionally, in RRM2 small hairpin (sh)RNA lentivirus-infected cells, the levels of phosphorylated Akt and MMP-9 were significantly decreased compared with control shRNA lentivirus-infected cells.

Conclusion
The present study demonstrated that RRM2 promoted the Akt phosphorylation leading to high expression of MMP-9 to promote the migration and invasive capacities of MH7A cells. Overall, IGF2BP promotes the expression of RRM2, and regulates the migration and invasion of MH7A cells via Akt/MMP-9 pathway to promote RA progression.
Development and testing of a questionnaire on the expectations and experiences with wearing face masks in inpatient and day hospitals
Authors: Kuczyk Charlotte , Münch Kathrin , Nöhre Mariel , Stephan Michael , de Zwaan Martina 
Published: May 2024

Background
The Covid-19 pandemic made wearing of face masks mandatory in the psychotherapeutic context. Against this background, the present study aimed to compare the expectations of patients undergoing day-hospital or inpatient treatment regarding wearing a mask in psychotherapy before the start of therapy with the final experience after the end of therapy. The study also investigated the extent to which expectations and experiences were influenced by other factors such as socio-demographic characteristics, patients’ general attitudes towards wearing a mask, duration of treatment, or mental health diagnoses.

Methods
Patients’ expectations and experiences were recorded using two versions of a self-developed questionnaire: the pre-version, which was administered before the start of therapy and recorded expectations, and the post-version, which was administered after the end of therapy and recorded the final experiences. An exploratory factor analysis was conducted for the questionnaire’s pre- and post-version. T-tests for paired samples were calculated to compare the patients’ expectations regarding the extracted factors with the final experiences. Bivariate correlations were calculated to explore the association of other potential factors with expectations and experiences.

Results
The exploratory factor analysis revealed a three-factor structure: communication barriers, self-confidence, and infection protection. The communication barriers expected by the patients before the start of the therapy turned out to be significantly higher than ultimately experienced after the therapy. Higher age correlated significantly negatively with expectations and experiences, with less self-confidence expected and experienced in therapy with a mask by older patients. There was a significant positive correlation between the expectations and the duration of treatment. Patients’ general attitudes correlated significantly with their expectations and experiences.

Conclusion
Based on the results, wearing a mask does not appear to negatively impact the success of psychotherapy from the patient’s perspective. However, patient-specific characteristics also appear to play a role in this context.