bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cooled versus conventional radiofrequency treatment of the genicular nerves for chronic knee pain: 12-month and cost-effectiveness results from the multicenter COCOGEN trial
Authors: Belba Amy , Vanneste Thibaut , Kallewaard Jan Willem , van Kuijk Sander MJ , Gelissen Marloes , Emans Peter , Bellemans Johan , Smeets Kristof , Van Boxem Koen , Sommer Micha , Kimman Merel , Van Zundert Jan 
Published: June 2024

Background
Radiofrequency (RF) treatment of the genicular nerves reduces chronic knee pain in patients with osteoarthritis (OA) or persistent postsurgical pain (PPSP) after total knee arthroplasty (TKA). The objective of this study is to compare long-term outcomes of cooled and conventional RF and perform an economic evaluation.

Methods
The COCOGEN trial is a double-blinded, non-inferiority, pilot, randomized controlled trial that compared the effects up to 12 months of cooled and conventional RF in patients with chronic knee pain suffering from OA or PPSP after TKA following a 1:1 randomization rate. Outcomes were knee pain, functionality, quality of life, emotional health, medication use, and adverse events. A trial-based economic evaluation was performed with a 12-month societal perspective. Here, the primary outcome was the incremental costs per quality-adjusted life year (QALY).

Results
41 of the 49 included patients completed the 12-month follow-up. One patient in the PPSP cooled RF group had substantial missing data at 12-month follow-up. The proportion of patients with ≥50% pain reduction at 12 months was 22.2% (4/18) in patients treated with conventional RF versus 22.7% (5/22) in patients treated with cooled RF (p>0.05). There was a statistically significant difference in the mean absolute numerical rating scale at 12 months after cooled RF and conventional RF in patients with PPSP (p=0.02). Differences between other outcomes were not statistically significant. The health economic analysis indicated that cooled RF resulted in lower costs and improved QALYs compared with conventional RF in PPSP but not in OA. There were no serious adverse events.

Conclusions
Both RF treatments demonstrated in approximately 22% of patients a ≥50% pain reduction at 12 months. In patients with PPSP, contrary to OA, cooled RF seems to be more effective than conventional RF. Additionally, cooled RF has in patients with PPSP, as opposed to OA, greater effectiveness at lower costs compared with conventional RF.

Trial registration number

NCT03865849
.
Association between sinusitis and incident rheumatic diseases: a population-based study
Authors: Kronzer Vanessa L , Davis John M , Hanson Andrew C , Sparks Jeffrey A , Myasoedova Elena , Duarte-Garcia Ali , Hinze Alicia M , Makol Ashima , Koster Mattew J , Vassallo Robert , Warrington Kenneth J , Wright Kerry , Crowson Cynthia S 
Published: June 2024

ObjectivesTo determine whether antecedent sinusitis is associated with incident rheumatic disease.MethodsThis population-based case–control study included all individuals meeting classification criteria for rheumatic diseases between 1995 and 2014. We matched three controls to each case on age, sex and length of prior electronic health record history. The primary exposure was presence of sinusitis, ascertained by diagnosis codes (positive predictive value 96%). We fit logistic regression models to estimate ORs for incident rheumatic diseases and disease groups, adjusted for confounders.ResultsWe identified 1729 incident rheumatic disease cases and 5187 matched controls (mean age 63, 67% women, median 14 years electronic health record history). After adjustment, preceding sinusitis was associated with increased risk of several rheumatic diseases, including antiphospholipid syndrome (OR 7.0, 95% CI 1.8 to 27), Sjögren’s disease (OR 2.4, 95% CI 1.1 to 5.3), vasculitis (OR 1.4, 95% CI 1.1 to 1.9) and polymyalgia rheumatica (OR 1.4, 95% CI 1.0 to 2.0). Acute sinusitis was also associated with increased risk of seronegative rheumatoid arthritis (OR 1.8, 95% CI 1.1 to 3.1). Sinusitis was most associated with any rheumatic disease in the 5–10 years before disease onset (OR 1.7, 95% CI 1.3 to 2.3). Individuals with seven or more codes for sinusitis had the highest risk for rheumatic disease (OR 1.7, 95% CI 1.3 to 2.4). In addition, the association between sinusitis and incident rheumatic diseases showed the highest point estimates for never smokers (OR 1.7, 95% CI 1.3 to 2.2).ConclusionsPreceding sinusitis is associated with increased incidence of rheumatic diseases, suggesting a possible role for sinus inflammation in their pathogenesis.
Rationale and design of ProUrokinase in Mild IsChemic strokE (PUMICE): a multicentre, prospective, randomised, open-label, blinded-endpoint controlled trial
Authors: Xiong Yunyun , Hao Manjun , Pan Yuesong , Duan Chunmiao , Feng Xueyan , Li Hao , Wu Na , Wang Liyuan , Meng Xia , Zhao Xingquan , Wang Yongjun 
Published: June 2024

Background and purposeRecombinant human prourokinase (rhPro-UK) is a new generation of specific plasminogen activator, that is non-inferior to alteplase in acute ischemic stroke. We aimed to investigate the efficacy and safety of rhPro-UK compared with standard medical treatment in acute mild ischemic stroke within 4.5 hours of symptom onset.Methods and designProurokinase in mild ischemic stroke is a multicentre, prospective, randomised, open-label, blinded-endpoint controlled trial. Patients who had an acute ischemic stroke within 4.5 hours from symptom onset and with baseline National Institutes of Health Stroke Scale (NIHSS) score ≤ 5 will be recruited. Patients will be randomly assigned (1:1) to receive intravenous rhPro-UK (35 mg) or standard medical treatment. The follow-up duration will be 90 days. The calculated sample size is 1446.Study outcomesPrimary efficacy outcome is an excellent functional outcome, defined as a modified Rankin Scale (mRS) score ≤ 1 at 90 days. Secondary efficacy outcomes include ordinal distribution of mRS at 90 days, mRS score ≤ 2 at 90 days, early neurological improvement at 24 hours (a decrease of NIHSS score ≥ 4 points compared with baseline or NIHSS score ≤ 1 point), Barthel index of 75–100 points at 90 days, quality of life at 90 days, and activities of daily living at 90 days. Safety outcomes are symptomatic intracranial haemorrhage within 36 hours, mortality at 90 days, moderate and severe systematic bleeding at 90 days, and adverse events/serious adverse events within 90 days.DiscussionThis large phase III randomised clinical trial will answer the question of whether thrombolysis is beneficial for acute mild ischemic stroke, and may provide evidence for rhPro-UK in patients had an acute mild ischemic stroke within 4.5 hours of symptom onset.Trial registration numberISRCTN05507645
Personalized ctDNA for Monitoring Disease Status in Head and Neck Squamous Cell Carcinoma
Authors: Hanna Glenn J. , Dennis Michael J. , Scarfo Nicole , Mullin Michelle S. , Sethi Rosh K.V. , Sehgal Kartik , Annino Donald J. , Goguen Laura A. , Haddad Robert I. , Tishler Roy B. , Margalit Danielle N. , Uppaluri Ravindra , Schoenfeld Jonathan D. , Rettig Eleni M. 
Published: June 2024

Abstract

Purpose:
Many patients with locoregionally advanced human papillomavirus–negative head and neck squamous cell carcinoma (HNSCC) relapse. ctDNA has the potential to identify minimal residual disease, but its clinical utility for virus-negative HNSCC is not well understood.

Experimental Design:
We retrospectively evaluated a personalized, commercial ctDNA assay (Signatera, Natera) during clinical care of patients treated for predominantly newly diagnosed human papillomavirus–negative HNSCC. Signatera utilizes 16-plex PCR from matched tumor and blood. Objectives were to understand ctDNA detectability and correlate changes posttreatment with disease outcomes.

Results:
Testing was successful in 100/116 (86%) patients (median age: 65 years, 68% male, 65% smokers); testing failed in 16 (14%) because of insufficient tissue. Oral cavity (55, 47%) tumors were most common; most had stage III to IV disease (82, 71%), whereas 17 (15%) had distant metastases. Pretreatment, 75/100 patients with successful testing (75%) had detectable ctDNA (range: 0.03–4049.69 mean tumor molecules/mL). No clinical features predicted ctDNA detectability or levels (multivariate analysis). At a median follow-up of 5.1 months (range: 0.2–15.1), 55 (55%) had &gt;1 test result (range: 1–7; 194 samples). Of 55 patients, 17 (31%) remained ctDNA positive after starting treatment. Progression-free survival was significantly worse for patients who were ctDNA positive versus ctDNA negative posttreatment (HR, 7.33; 95% confidence interval, 3.12–17.2; P &lt; 0.001); 1-year overall survival was 89.1% versus 100%, respectively (HR, 7.46; 95% confidence interval, 0.46–119.5; P = 0.155).

Conclusions:
Tumor-informed ctDNA testing is feasible in nonviral HNSCC. ctDNA positivity is an indicator of disease progression and associated with inferior survival. Further research is warranted to understand whether ctDNA may be leveraged to guide therapy in HNSCC.
Rescue Stenting after Unsuccessful Recanalization of Endovascular Thrombectomy of the Posterior Circulation: A Systematic Review and Meta Analysis
Authors: Brake Aaron , Danso Emmanuel , Liu William , Galate Vince , Fry Lane , Abraham Michael 
Published: June 2024

Background
The role of rescue stenting (RS) in acute ischemic strokes due to intracranial atherosclerotic disease–related large vessel occlusion is an area of active investigation. This study evaluates the efficacy and safety of RS under these circumstances.

Methods
A systematic literature review, conforming to Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines, was conducted across PubMed, EMBASE, Cochrane, and OVID databases. Common and random effects analyses were conducted to compare outcomes including modified Rankin Scale score, 90‐day mortality, and symptomatic intracranial hemorrhage between patients receiving and those not receiving RS after failed endovascular thrombectomy within posterior circulation.

Results

Ten studies comprising 1202 patients (730 RS, 472 control) were analyzed. RS was associated with a statistically significant improvement in functional outcomes, evidenced by a higher proportion of patients achieving modified Rankin Scale score ≤2 at 90 days (32.74% versus 21.19% in controls;
P
<0.001). Additionally, RS showed a significant reduction in 90‐day mortality (33.28% versus 54.66% in controls;
P
<0.001) and a lower incidence of symptomatic intracranial hemorrhage (3.74% versus 9.49% in controls;
P
<0.001).

Conclusion
RS for acute ischemic stroke in the context of intracranial atherosclerotic diseaserelated posterior circulation large vessel occlusion after failed endovascular thrombectomy is associated with improved functional outcomes, reduced mortality, and decreased symptomatic intracranial hemorrhage rates. These findings suggest RS as a beneficial intervention in this patient population. However, the retrospective nature of the included studies and their heterogeneity underline the need for further research, particularly through randomized controlled trials.
Chasing information literacy into the wild
Authors: Lloyd Annemaree 
Published: June 2024

In the context of information literacy (IL) research, the Anthropocene age offers an opportunity for researchers to explore to develop a more sophisticated understanding of the complexity of information literacy which result from rapid and complex social, political and economic change; to address the risk of societal fragmentation which is created by misinformation/disinformation; and to understand the risk to democratically encouraged information environments that will come with increasing incorporation of AI and opinion-driven social platforms into everyday life. For library practitioners who provide instruction or education, challenges exist in relation to scaffolding and encouraging sustainable, transferrable information and technological practices, not only in our own inward facing professional practice but in our outward facing practice with the myriad communities we support. Against this problematisation, this brief, but broad ranging paper aims to identify a range of questions for thinking about the practice of IL in the Anthropocenic age. No attempt is made to answer these questions, instead they act as an impetus for future researchers and practitioner researchers.
Lifestyle factors, physical health, and life satisfaction under different changes in depressive symptoms among Chinese community-dwelling older adults: A longitudinal analysis
Authors: Peng Man-Man , Liang Zurong , Wang Pengfei 
Published: June 2024

Background: The study aims to investigate the long-term impact of lifestyle-related factors and physical health on life satisfaction and depressive symptoms among Chinese community-dwelling older adults. Methods: Using data from the China Health and Retirement Longitudinal Study (CHARLS), the analytic sample of this study included 1,068 older adults who had participated in the surveys in both 2011 and 2018. Multivariate regression was employed to analyze both cross-sectional and longitudinal relationships between lifestyle-related factors, physical health, and subjective well-being – specifically depressive symptoms and life satisfaction. Additionally, the model tested how these factors correlate with life satisfaction across different groups of depressive symptom changes among older adults, categorized as not at risk of depression, intermittent depression, and chronic depression. Results: Multimorbidity was significantly related to baseline and follow-up depressive risk in older adults. Shorter sleep duration was associated with baseline depression risk. Current alcohol drinkers reported significantly more severe depressive symptoms than non-drinkers. At baseline, current smokers were more likely to have a lower degree of life satisfaction than nonsmokers. Among older adults with chronic depression at the 7-year follow-up, former smokers tended to have lower life satisfaction than nonsmokers. Conclusions: Our findings identified drinking alcohol and having a shorter sleep duration as modifiable lifestyle-related risk factors for late-life depression and smoking as a detrimental factor for life satisfaction in older Chinese adults. Multimorbidity was a significant predictor of more depressive symptoms. Our findings have implications for future psychosocial interventions that target the alleviation of depressive symptoms and the promotion of life satisfaction in older Chinese people based on their different long-term mental and physical health conditions.
Social Determinants of Health and Psychological Capital Among Youth Experiencing Homelessness
Authors: Preston Angela J. , Rew Lynn , Spees Jason 
Published: June 2024

Background: Social determinants of health affect health behaviors and outcomes. Youth experiencing homelessness suffer significant deprivation of resources such as inadequate housing, reduced education, poor health care, and decreased economic stability. Inner resources, such as psychological capital, may also be related to health behaviors and health outcomes. Objective: In this study, we sought to describe and explore associations among selected determinants of health and self-reported scores on indicators of psychological capital among youth experiencing homelessness. Methods: This cross-sectional secondary analysis was conducted with a randomized subsample of 148 youth. We calculated chi-square frequencies to describe the data, classical item analyses to evaluate responses, and correlation tests to examine significance of associations. Results: Youth in this sample demonstrated that they possess inner resources associated with determinants of health. Education, health care, and social support were significantly associated with attributes of psychological capital (hope, efficacy, resilience, optimism). Sexual minority groups had high representation in this subsample (25.7%), indicating a need for more study and equitable services for this population. Conclusion: More research should be conducted to better understand the associations between determinants of health, psychological capital, and health behaviors among disadvantaged youth to advance health equity initiatives.
Prevalence of Cardiovascular Risk Factors in Rural Kenya—2023: Vihiga II
Authors: Shishani Kawkab , Kaduka Lydia , Olale Joanna , Mbuka Schiller , Mutai Joseph , Ochieng Rodgers , Muniu Erastus , Sivarajan Froelicher Erika 
Published: June 2024

Background: The aim of this study was to estimate the prevalence of cardiovascular disease (CVD) risk factors among adults in Vihiga County, Western Kenya. Methods: A cross-sectional population-based study was completed. Participants ( n = 575) were selected at the household level using a systematic random sample, and sociodemographic, anthropometrical, clinical, and biochemical data were collected. Results: The sample consisted of 71.8% women and 28.2% men. The prevalence of high blood pressure (BP) was 56.4%. A greater proportion of women (62.8%) had low levels of high-density lipoprotein (HDL) compared with men (44.7%) (odds ratio [OR], 2.99; 95% CI, 1.59-5.64). High triglyceride levels were more prevalent in men (16.4%) compared with women (15.4%) (OR, 0.37; 95% CI, 0.19-0.71). Based on average waist to hip ratio, abdominal obesity was significantly higher in women (55.4%) compared with men (27.6%) (OR, 2.62; 95% CI, 1.52-4.49). Low levels of physical inactivity were prevalent in women (36.3%) at significantly higher proportions compared with men (22.7%) (OR, 1.73; 95% CI, 1.02-2.92). Women used tobacco at significantly lower proportions (0.5%) compared with men (27.2%) (OR, 0.01; 95% CI, 0.00-0.06). A higher proportion of women (47.9%) rated their general health as poor compared with men (37.1%), a statistically significant difference (OR, 2.0; 95% CI, 1.23-3.28). Conclusion: The prevalence of CVD risk factors, such as hypertension, obesity, dyslipidemia, low physical activity, and tobacco use indicates the urgent need for comprehensive health promotion programs to improve public health in rural areas of Kenya.
Profiling of Graphophonological Semantic Flexibility in Typical Readers: A Cross-sectional Study
Authors: Varghese Sneha Mareen , Shanbal Jayashree C. 
Published: June 2024

Background: Graphophonological semantic flexibility (GSF) is a reading-specific cognitive flexibility that allows an individual to process a print’s phonological and semantic elements simultaneously. The study aimed to explore the developmental profile of GSF in typical readers. Method: Ninety typically developing children, ages 8 to 11 years, were recruited and divided into three age groups: 8, 9, and 10. They were given a web-based GSF task that required them to arrange 12-word cards in a 2 × 2 matrix according to their initial phoneme and meaning. Several GSF components were computed, such as sorting speed, accuracy, and index. Furthermore, word reading, non-word reading, and passage comprehension were used to assess their reading profile. Results: The Kruskal-Wallis analysis revealed significant differences in sorting accuracy (H (2) = 32.67, p < .001), speed (H (2) = 20.25, p < .001), and index (H (2) = 26.97, p < .001) across all ages. According to Dunn’s post hoc analysis, accuracy improved across all age groups (p < .01) and in the index between 8 and 10 ( p < .001). The Mann–Whitney U test showed gender differences in sorting speed (U = 717, p = .03). Additionally, Spearman’s rank correlation showed a significant positive association between GSF and word reading ( r = 0.47, p < .001) and text comprehension ( r = 0.55, p < .001). Conclusion: The findings demonstrated that GSF components are developmental and do not significantly impact gender other than sorting speed. Furthermore, a relationship between GSF and word reading and passage comprehension emerged.
Hemodynamic analysis of thoracic endovascular aortic repair with left subclavian artery reconstructed by chimney stent
Authors: Ding Yunpeng , Xu Chunbo , Yang Tiequan , Wang Shuyuan , Wang Di , Hu Songjie , Lang Dehai 
Published: June 2024

Objectives The purpose of this study was to investigate the hemodynamic consequences of thoracic endovascular aortic repair which reconstructed left subclavian artery by chimney stent (ch-TEVAR). Methods Two patients who underwent thoracic endovascular aortic repair (TEVAR) and left subclavian artery (LSA) reconstruction using chimney stents were selected. Preoperative and postoperative CTA images were collected to reconstruct hemodynamic models for comparing and analyzing blood pressure, blood flow velocity, and wall shear stress in the aortic arch and its major branches. Concurrently, morphological alterations and position of chimney stent were also assessed. Results After the reconstruction of LSA in ch-TEVAR, no endoleak was seen, but the stent in LSA was compressed. The blood flow velocity of the LSA increased and disordered, the pressure was reduced, and the WSS was increased. Even more, there were a large amount of turbulence found in the LSA of one case, and its LSA was blocked. Conclusion Chimney stent reduces the occurrence of endoleak due to its excellent deformation ability, but the compressed stent has a greater impact on the hemodynamics of LSA and eventually leads to LSA occlusion; in order to keep the LSA unobstructed, it is necessary to pay attention to the position of the chimney stent and keep it straight and do not fold or twist. Chimney stent has little influence on the aortic arch and the rest of the aortic arch branches.