bluuebunny/crossref_metadata_2025_split huggingface dataset:
High NRBP1 expression in prostate cancer is linked with poor clinical outcomes and increased cancer cell growth
Authors: Ruiz Christian , Oeggerli Martin , Germann Markus , Gluderer Silvia , Stocker Hugo , Andreozzi Mariacarla , Thalmann George N. , Cecchini Marco G. , Zellweger Tobias , Stürm Susanna , Koivisto Pasi A. , Helin Heikki J. , Gelmann Edward P. , Glass Andrew G. , Gasser Thomas C. , Terracciano Luigi M. , Bachmann Alexander , Wyler Stephen , Bubendorf Lukas , Rentsch Cyrill A. 
Published: April 2012

AbstractBACKGROUNDWe recently established the rationale that NRBP1 (nuclear receptor binding protein 1) has a potential growth‐promoting role in cell biology. NRBP1 interacts directly with TSC‐22, a potential tumor suppressor gene that is differently expressed in prostate cancer. Consequently, we analyzed the role of NRBP1 expression in prostate cancer cell lines and its expression on prostate cancer tissue microarrays (TMA).METHODSThe effect of NRBP1 expression on tumor cell growth was analyzed by using RNAi. NRBP1 protein expression was evaluated on two TMAs containing prostate samples from more than 1,000 patients. Associations with clinico‐pathological features, the proliferation marker Ki67 and survival data were analyzed.RESULTSRNAi mediated silencing of NRBP1 expression in prostate cancer cell lines resulted in reduced cell growth (P < 0.05). TMA analysis revealed NRBP1 protein expression in benign prostate hyperplasia in 6% as compared to 60% in both, high‐grade intraepithelial neoplasia and prostate cancer samples. Strong NRBP1 protein expression was restricted to prostate cancer and correlated with higher expression of the proliferation marker Ki67 (P < 0.05). Further, patients with strong NRBP1 protein expression showed poor clinical outcomes (P < 0.05). Analysis of matched localized cancer tissues before and after castration revealed that post‐therapy‐related repression of NRBP1 expression was significantly associated with better overall survival.CONCLUSIONSWe demonstrate that expression of NRBP1 is up‐regulated during the progression of prostate cancer and that high NRBP1 expression is linked with poor prognosis and enhanced tumor cell growth. Prostate 72:1678–1687, 2012. © 2012 Wiley Periodicals, Inc.
Spatial Assimilation and Native Partnership: Evidence of Iranian and Iraqi Immigrant Mobility from Segregated Areas in Stockholm, Sweden
Authors: Macpherson Robert A. , Strömgren Magnus 
Published: April 2012

ABSTRACTStudies testing ‘spatial assimilation’ are no longer restricted to traditional suburbanisation movements correlated with high education, income, and exposure to the ‘majority’ population. Instead, greater emphasis is now being placed on other ‘cultural’ and ‘social’ aspects associated with assimilation and different patterns of movements. Although these ideas have remained dominant in North America, fewer studies have tested their applicability in European contexts. This paper addresses this by examining the spatial mobility of Iranian and Iraqi immigrants from segregated areas within Stockholm County, Sweden. By using register data for individuals for the years 2001 and 2007, we reveal through binary logistic regressions how significant differences emerge between those who move and those who stay, particularly for human capital (education) prior to movement and social capital (having a ‘Swedish’ partner) after movement. This raises important questions for future research dealing with issues of integration, segregation, and mobility. Copyright © 2012 John Wiley & Sons, Ltd.
Dirac's theorem for random graphs
Authors: Lee Choongbum , Sudakov Benny 
Published: April 2012

AbstractA classical theorem of Dirac from 1952 asserts that every graph on n vertices with minimum degree at least
\documentclass{article} \usepackage{mathrsfs} \usepackage{amsmath} \pagestyle{empty} \begin{document} \begin{align*}\left\lceil n/2 \right\rceil\end{align*} \end{document}
is Hamiltonian. In this paper we extend this result to random graphs. Motivated by the study of resilience of random graph properties we prove that if p ≫ log n/n, then a.a.s. every subgraph of G(n,p) with minimum degree at least (1/2 + o (1))np is Hamiltonian. Our result improves on previously known bounds, and answers an open problem of Sudakov and Vu. Both, the range of edge probability p and the value of the constant 1/2 are asymptotically best possible. © 2012 Wiley Periodicals, Inc. Random Struct. Alg., 2012
Offshoring and firm innovation: The moderating role of top management team attributes
Authors: Mihalache Oli R. , Jansen Justin J. J. P. , Van Den Bosch Frans A. J. , Volberda Henk W. 
Published: April 2012

AbstractThis study attempts to increase the understanding of how offshoring influences the introduction of new products and services. Focusing on the offshoring of those business functions that provide direct knowledge inputs for innovation (i.e., production, R&D, and engineering), we propose that offshoring has an inverted U‐shaped influence on firm innovativeness. Additionally, we provide an upper echelon contingency perspective by considering the moderating role of two top management team (TMT) attributes (i.e., informational diversity and shared vision). Using a cross‐industry sample with lagged data, we find that offshoring has an inverted U‐shaped influence on firm innovativeness and that this relationship is steeper in firms with high TMT informational diversity and in firms with low TMT shared vision. Copyright © 2012 John Wiley & Sons, Ltd.
Age-Related Changes in Speed and Mechanism of Adult Skeletal Muscle Stem Cell Migration
Authors: Collins-Hooper Henry , Woolley Thomas E. , Dyson Louise , Patel Anand , Potter Paul , Baker Ruth E. , Gaffney Eamonn A. , Maini Philip K. , Dash Philip R. , Patel Ketan 
Published: April 2012

Abstract
Skeletal muscle undergoes a progressive age-related loss in mass and function. Preservation of muscle mass depends in part on satellite cells, the resident stem cells of skeletal muscle. Reduced satellite cell function may contribute to the age-associated decrease in muscle mass. Here, we focused on characterizing the effect of age on satellite cell migration. We report that aged satellite cells migrate at less than half the speed of young cells. In addition, aged cells show abnormal membrane extension and retraction characteristics required for amoeboid-based cell migration. Aged satellite cells displayed low levels of integrin expression. By deploying a mathematical model approach to investigate mechanism of migration, we have found that young satellite cells move in a random “memoryless” manner, whereas old cells demonstrate superdiffusive tendencies. Most importantly, we show that nitric oxide, a key regulator of cell migration, reversed the loss in migration speed and reinstated the unbiased mechanism of movement in aged satellite cells. Finally, we found that although hepatocyte growth factor increased the rate of aged satellite cell movement, it did not restore the memoryless migration characteristics displayed in young cells. Our study shows that satellite cell migration, a key component of skeletal muscle regeneration, is compromised during aging. However, we propose clinically approved drugs could be used to overcome these detrimental changes.
Disclosure of potential conflicts of interest is found at the end of this article.
Enhanced Homing Permeability and Retention of Bone Marrow Stromal Cells by Noninvasive Pulsed Focused Ultrasound
Authors: Ziadloo Ali , Burks Scott R. , Gold Eric M. , Lewis Bobbi K. , Chaudhry Aneeka , Merino Maria J. , Frenkel Victor , Frank Joseph A. 
Published: April 2012

Abstract
Bone marrow stromal cells (BMSCs) have shown significant promise in the treatment of disease, but their therapeutic efficacy is often limited by inefficient homing of systemically administered cells, which results in low number of cells accumulating at sites of pathology. BMSC home to areas of inflammation where local expression of integrins and chemokine gradients is present. We demonstrated that nondestructive pulsed focused ultrasound (pFUS) exposures that emphasize the mechanical effects of ultrasound-tissue interactions induced local and transient elevations of chemoattractants (i.e., cytokines, integrins, and growth factors) in the murine kidney. pFUS-induced upregulation of cytokines occurred through approximately 1 day post-treatment and returned to contralateral kidney levels by day 3. This window of significant increases in cytokine expression was accompanied by local increases of other trophic factors and integrins that have been shown to promote BMSC homing. When BMSCs were intravenously administered following pFUS treatment to a single kidney, enhanced homing, permeability, and retention of BMSC was observed in the treated kidney versus the contralateral kidney. Histological analysis revealed up to eight times more BMSC in the peritubular regions of the treated kidneys on days 1 and 3 post-treatment. Furthermore, cytokine levels in pFUS-treated kidneys following BMSC administration were found to be similar to controls, suggesting modulation of cytokine levels by BMSC. pFUS could potentially improve cell-based therapies as a noninvasive modality to target homing by establishing local chemoattractant gradients and increasing expression of integrins to enhance tropism of cells toward treated tissues.
Disclosure of potential conflicts of interest is found at the end of this article.
Kraftstoffersparnis durch Hochleistungswerkstoffe
Authors: Bobzin Kirsten , Bagcivan Nazlim , Verpoort Clemens , Schramm Leander , Yilmaz Koray , Theiß Sebastian 
Published: April 2012

AbstractDurch europäische Anordnungen wird der Fortschritt bei der Effizienz von Personenkraftwagen immer wieder forciert. Dies soll maßgeblich durch zwei Maßnahmen erreicht werden. Einerseits kann durch einen konsequenten Leichtbau mit höherfesten Stählen und Leichtmetallen wie Aluminium eine Effizienzsteigerung erzielt werden. Andererseits werden immer öfter Beschichtungen eingesetzt, um Reibungsverluste zu reduzieren. Ein Beispiel, bei dem beide Maßnahmen gleichermaßen eingesetzt werden, ist der Motorenbau. Im Motor werden einerseits Leichtmetalle eingesetzt, um das Fahrzeuggewicht zu reduzieren, und Beschichtungen, um eine maximale Gewichtsreduzierung und einen verbesserten Wirkungsgrad zu erreichen. So werden thermische Spritzverfahren eingesetzt, um die Zylinderlaufbahn eines Leichtmetallmotorblocks vor Verschleiß zu schützen. Um das tribologische System für eine solche Zylinderlaufbahn zu optimieren, können neue mittels Physical Vapour Deposition (PVD) abgeschiedene Dünnschichten auf Kolbenringen die Reibverluste reduzieren und geringeren Verschleiß gewährleisten.
G‐quadruplexes in RNA biology
Authors: Millevoi Stefania , Moine Hervé , Vagner Stéphan 
Published: April 2012

AbstractG‐quadruplexes are noncanonical structures formed by G‐rich DNA and RNA sequences that fold into a four‐stranded conformation. Experimental studies and computational predictions show that RNA G‐quadruplexes are present in transcripts associated with telomeres, in noncoding sequences of primary transcripts and within mature transcripts. RNA G‐quadruplexes at these specific locations play important roles in key cellular functions, including telomere homeostasis and gene expression. Indeed, RNA G‐quadruplexes appear as important regulators of pre‐mRNA processing (splicing and polyadenylation), RNA turnover, mRNA targeting and translation. The regulatory mechanisms controlled by RNA G‐quadruplexes involve the binding of protein factors that modulate G‐quadruplex conformation and/or serve as a bridge to recruit additional protein regulators. In this review, we summarize the current knowledge on the role of G‐quadruplexes in RNA biology with particular emphasis on the molecular mechanisms underlying their specific function in RNA metabolism occurring in physiological or pathological conditions. WIREs RNA 2012, 3:495–507. doi: 10.1002/wrna.1113This article is categorized under:

RNA Structure and Dynamics > Influence of RNA Structure in Biological Systems
RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications
Genistein, a soya isoflavone, prevents azoxymethane-induced up-regulation of WNT/β-catenin signalling and reduces colon pre-neoplasia in rats
Authors: Zhang Yukun , Li Qian , Zhou Dan , Chen Hong 
Published: April 2012

The present study aimed to explore the role(s) of the soya isoflavone genistein (GEN) in preventing the development of colon pre-neoplasia, using Wingless/int (WNT)/β-catenin as a molecular marker of colon abnormality. Specifically, the effects on the WNT/β-catenin signalling pathway from GEN were examined by using an azoxymethane (AOM)-induced rat colon cancer model. Male Sprague–Dawley rats were fed a control (CTL), a soya protein isolate (SPI) or a GEN diet from gestation to 13 weeks of age. The first sampling was conducted at 7 weeks of age for pre-AOM analysis. The remaining rats were injected with AOM at 7 weeks of age. The descending colon was collected 6 weeks later for the evaluation of aberrant crypt foci (ACF), gene expression and nuclear protein accumulation. AOM injection induced aberrant nuclear accumulation of β-catenin in the CTL group but not in the SPI or GEN group. Moreover, the WNT target genesCyclin D1andc-Mycwere repressed by SPI and GEN. Meanwhile, SPI and GEN suppressed the expression of WNT signalling genes includingWnt5a,Sfrp1,Sfrp2andSfrp5to the similar level to that of the pre-AOM period. Rats fed SPI and GEN had a decreased number of total aberrant crypts. GEN feeding also resulted in a reduced number of ACF withN = 3 per foci. The reduction of WNT/β-catenin signalling was correlated with the decrease in total aberrant crypts. By testing WNT/β-catenin signalling as a biomarker of colon carcinogenic potential, we showed the novel role of GEN as a suppressor of carcinogen-induced WNT/β-catenin signalling in preventing the development of early colon neoplasia.
Distribution patterns of deep-sea fish and benthic invertebrates from trawlable grounds of the Hatton Bank, north-east Atlantic: effects of deep-sea bottom trawling
Authors: Durán Muñoz P. , Sayago-Gil M. , Patrocinio T. , González-Porto M. , Murillo F. J. , Sacau M. , González E. , Fernández G. , Gago A. 
Published: April 2012

Distributions of deep-sea fish, benthic invertebrates and the effects of deep-sea bottom trawling were studied based on data collected in 2005 from a joint collaboration survey undertaken between the Spanish Institute of Oceanography and a deep-sea trawler on the Hatton Bank (north-east Atlantic). A total of 163 valid bottom trawl hauls (600–1600 m) were analysed. The main trawlable grounds were located on the sedimentary seabed of the western flank of the bank (Hatton Drift). Grenadiers and smoothheads were predominant in the trawl catches (67% and 11.8% by weight respectively). Both species were abundant along the western flank. Deep-water sharks accounted for 7.4% of weight, and were abundant along the south-eastern slopes. Chimerids, lotids, morids and other deep-sea species were also taken as by-catch. Grenadiers and deep-water sharks dominated the discards. By-catches of cold-water corals were generally associated with the rocky outcrop and were more abundant at the top of the bank. Abundant by-catches of large sponges, characteristic of sponge-dominated biotopes, were taken from the eastern flank.
William Forsythe, Eidos:Telos, and Intertextual Criticism
Authors: Nugent Ann 
Published: April 2012

At my first performance of Eidos:Telos, in Frankfurt in 1998, I discover a work of penetrating power that is both ordered and disordered. It is febrile at one moment and cool at the next. It is abstract but threaded through with symbolism, and its three acts exude darkness and mystery.There are no obvious divisions into time or place, and the weave of obscure and fragmented allusions means that dramas build and drop away. The dancing bodies create a mass of curves, lines, and angles with astonishing fluency but in few centrally organized patterns. I try to make sense of the diversity of abstract dance that seems rooted in evasive purpose, and symbolism that lends itself to poetics rather more often than to literal meaning. I search for metaphors that will bind images together, but the imagery is delivered faster than the speed of thought. The movement is rooted in ballet, and fleetingly I sense Apollo lingering; warm to a fragment of Giselle and feel a frisson of excitement when a man sinks to the ground and folds over his body, because it reminds me of Nijinsky's L'Aprés midi d'un faune. But though these connections continue to burn in my mind, they are incidentals and personal to what I see, and quickly succeeded by others.But I leave Eidos:Telos feeling somehow different, for my body is pumping with energy and ideas, and colorful dynamics are colliding in my head. It has taken me on a journey of the philosophical, kinaesthetic, and sensual, and I need to experience more.
Dance Studies in the International Academy: Genealogy of a Disciplinary Formation
Authors: Giersdorf Jens Richard 
Published: April 2012

For the past thirteen years, I have been traveling to the United States from my home country of Germany, first as a graduate student in California and later as a professor living in New York. Every time I pass through immigration, I am asked a series of questions regarding my final destination and my occupation. The latter always leads to some confusion, because when I am asked what I do, my accent seems to turn “dance history” into “dentistry.” Forced by phonetics to use the term “dance studies,” when confronted by the blank face of the customs officer, I inevitably embark on an explanation of what “dance studies” might be. Just in the moment when I finally see some comprehension of my profession lighting up the officer's face, the question is asked: “And we pay you to do this?”I constantly find myself in the position of having to explain my work. Usually I avoid a long-winded, defensive justification by comparing dance studies to one of its neighboring disciplines: “It is like art history, just writing about dance instead of paintings.” That usually does the trick, but it leaves a foul taste in my mouth. I know that dance studies isn't like art history and I certainly don't want it to be.
From Shusterman's Somaesthetics to a Radical Epistemology of Somatics
Authors: Ginot Isabelle 
Published: April 2012

From the precepts of civility and physical deportment in the early modern era to modern gestural routines found in physical therapy and gymnastics, cultural historians of the body have studied the physical practices of hygiene, sports, and medicine. The history of dance is marked by these dance-related practices, which are peripheral to dance itself. One set of contemporary peripheral practices sought out by dancers themselves has been called “somatics,” a term Thomas Hanna proposed in the 1970s (1995). Somatics has since made its way into the dance world, where by now it has achieved widespread recognition as a form of bodily knowledge. This article is concerned with the epistemological status of somatics and, therefore, with the discursive production characteristic of its methods and practices.The first value that we usually attribute to these practices is prophylactic: they serve to prevent professional accidents or provide functional rehabilitation following injuries. Although increasingly integrated into dancer training and dance pedagogy, somatics first found its way into dance as a means to limit accidents. Somatics is also often a resource for the improvement of virtuosity in dance. But it has nevertheless transformed pedagogy into a more “active” and exploratory experience for the student, in which physical sensations are more important than the mirroring and reproduction of forms (Fortin 1996, 2005; Fortin, Long, and Lord 2002). We often see it presented as a “counter power,” an antidote to dominant dance practices. This point of view is poorly documented—possibly because it would not hold up against a strong argument—but it is common knowledge that somatics stands opposed to virtuosity and the “perfect” body image, as seen, for example, in the role these techniques played in the early part of Trisha Brown's choreographic career.
Le ‘Romain’ au théâtre des XVII
e
et XVIII
e
siècles: naissance d'un type comique
Authors: Chaouche Sabine 
Published: April 2012

Abstract

Cet article examine un sujet qui a été peu étudié par la critique: la représentation des ‘Grands Comédiens’ de la fin du dix-septième siècle à la première moitié du dix-huitième siècle. La mise en scène des pratiques scéniques en usage chez les ‘Comédiens ordinaires du Roy’ et l'imitation de leur style de jeu ont eu, dès la fin du dix-septième siècle, un succès incontestable auprès d'une certaine frange du public parisien. Ce sont en effet les italiens, puis les forains, ennemis de la Comédie-Française, qui créèrent un personnage nouveau dans le paysage théâtral français: le tragédien caricatural ou ‘Romain’. Nous nous proposons d'analyser les différentes formes de cette figure ridicule afin de mieux en saisir la portée, notamment son influence sur le développement du théâtre français. Privilégiant les textes sources, nous abordons des thèmes tels que l'art de l'acteur et la production des spectacles sous l'Ancien Régime (comme, par exemple, le costume). Tout en donnant une vue générale du contexte culturel et théâtral de l'époque, nous nous attachons plus particulièrement aux rivalités entre troupes parisiennes afin de montrer comment le théâtre des foires a inventé une nouvelle forme de
mimèsis
à travers l'art du pastiche.
Panton–Valentine leukocidin gene sequence variation and phage in methicillin‐resistant and methicillin‐susceptible Staphylococcus aureus from children in mainland China
Authors: Li Xiangmei , Sun Jing , Wu Dejing , Wang Lijuan , Yang Yonghong , Wang Chuanqing , Liu Lan , Zhao Changan , Du Pengcheng , Yu Sangjie , Shen Xuzhuang 
Published: April 2012

ABSTRACTTo determine the variation in the Panton–Valentine leukocidin (PVL) gene sequences and different PVL‐encoding phages of Staphylococcus aureus strains collected from children in mainland China, fifty‐eight strains with PVL collected from 2007 to 2009 were used. Their molecular characteristics were examined. Primers were designed to sequence the PVL genes. Six PVL‐encoding phages (ϕPVL, ϕ108PVL, ϕSLT, ϕSa2MW, ϕSa2958, and ϕSa2USA) were identified by PCR. Eleven sequence types (ST) were detected with ST59 (39.7%, 23/58) the most frequent ST, followed by 910 (22.4%, 13/58), and 338 (12.1%, 7/58). Single nucleotide polymorphisms (SNP) were identified at 11 locations in the PVL genes. SNP (nucleotide 1396, A→G) and SNP (nucleotide 1546, A→G) were observed in >10 sequences. Four additional SNP were non‐synonymous. Both SNP (nucleotide 16, C→A) and SNP (nucleotide 62, C→T) were present in the same ST59 strain. SNP (nucleotide 527, A→G) was present in five strains belonging to ST30, 121, 1, and 93. SNP (nucleotide 1436, A→C) was present in one ST30 strain. Fifteen strains belonging to ST910, ST217, and ST30 carried a PVL phage that had an icosahedral head morphology. Nine ST59 strains carried ϕ108PVL. Three ST88 strains carried a PVL phage that had an elongated head morphology. Twenty‐seven strains, including 60.9% (14/23) of ST59 and all ST338 strains, had no detectable phage. In conclusion, sequence variation in PVL genes and PVL‐encoding phages was generally related to the lineage. ST59 strains may indeed carry novel PVL phages.