bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ketamine’s efficacy in alleviating acute suicidal thoughts: a comprehensive systematic review and meta-analysis
Authors: Seyedoshohadaei Seyedeh Asrin , Darehbagh Ramyar Rahimi , Gholami Farshid , Nouri Elham , Babahajiani Media , Kohnepoushi Parisa , Moradi Yousef , AzizKhani Leila 
Published: May 2024

AbstractSuicidal ideation in patients with major depressive disorder (MDD) presents a critical challenge in mental health, with conventional antidepressants often having delayed onset. This systematic review and meta-analysis investigates the efficacy of ketamine in rapidly reducing acute suicidal ideation in this patient group. A comprehensive literature search up to June 2023 across PubMed (Medline), Scopus, Web of Science, and Embase yielded 12 studies, including 7 randomized controlled trials (RCTs). The evaluation of the impact of ketamine on Montgomery-Åsberg Depression Rating Scale-Suicidal Ideation (MADRS-SI) scores was conducted using the standardized mean difference (SMD) through the Cohen’s d method for analysis. The assessment of risk of bias was executed utilizing the Cochrane Risk of Bias Tool (RoB2). Subgroup assessments considered study period, geographic location, and follow-up duration. Ketamine administration showed a significant reduction in MADRS SI scores (mean difference, -1.16; 95% CI, -1.89, -0.23). Subgroup analysis revealed varying efficacy based on the study period, geographical location, and follow-up length. Intravenous ketamine demonstrated the most substantial reduction in suicidal thoughts. High heterogeneity among studies was observed. Ketamine offers a rapid and significant reduction in acute suicidal ideation in patients with MDD. It holds promise as an intervention during high-risk periods where conventional treatments are limited by slower onset. However, variability in study results and concerns over long-term safety necessitate further research to optimize treatment protocols and understand the implications of different administration routes. These findings have important implications for developing clinical guidelines in managing acute suicidal ideation in MDD.
Laparoscopy versus ultrasonography for the evaluation of Müllerian duct remnants in male patients with disorder of sex differentiation
Authors: Abd El-Monsif Mohamed Sayed , Arafa Noha , Marei Mahmoud Marei , Eltagy Gamal , Wishahy Ahmed M. K. 
Published: May 2024

Abstract
Background
The diagnosis of male differences of sex development is a challenging multidisciplinary team task, that requires external genital evaluation, karyotyping, hormonal profiling, radiological work up and frequently diagnostic laparoscopy and biopsy, for evaluation of internal duct system and nature of gonads. The debate still persists regarding the best diagnostic modality for accurate visualization of Müllerian duct remnants (MDRs) in those patients.
The aim of the study was to compare between laparoscopy (L) and ultrasonography (US) regarding the diagnostic accuracy in detection of Müllerian duct remnants, in addition to describing their anatomical nature and relations with the male duct system, in patients with male DSD, with various karyotypes.

Methods
We prospectively included 20 patients with male DSD, mostly due to 46 XY DSD or chromosomal DSD, over 2 years. The medical and radiological data were collected and analyzed.

Results
The age at the first diagnostic intervention ranged from 8 to 24 months (mean: 17 months). There were 14 patients with 46XY DSD with variable diagnoses (3 ovotesticular DSD, 3 partial gonadal dysgenesis, 6 persistent Müllerian duct remnants syndrome and 2 mixed gonadal dysgenesis). Two patients with 46XX DSD were included (one XX male, and one patient with ovotesticular DSD). One patient with chimerism (46XY/46XX) and three patients with 46XY/45XO mixed gonadal dysgenesis were also recruited. MDRs were evident in all cases (100%) by laparoscopy, only 25% (n = 5) were visualized by US. There was a statistically significant difference between laparoscopy and US regarding gonadal and MDR visualization, being higher with laparoscopy (p values, 0.0180 and 0.001).

Conclusions
Ultrasonography failed to visualize Müllerian remnants in 75% of patients with complex DSD. On the other hand, laparoscopy provided optimum visualization of MDRs and gonads in those children.
Evaluation of OxiOrganosolv pretreated hardwood and softwood lignocelluloses as substrates for the chemoenzymatic production of 5-hydroxymethylfurfural (HMF)
Authors: Dedes Grigorios , Karnaouri Anthi , Marianou Asimina A. , Zhang Yu , Lappas Angelos A. , Topakas Evangelos 
Published: May 2024

AbstractFurans, such as 5-hydroxymethylfurfural (HMF), are compounds of great importance that can serve as starting materials for the synthesis of polymers. Their production from lignocellulose-derived sugar streams offers a promising alternative to fossil fuels, while enabling biomass transformation to chemicals with higher value. In the present work, the production of HMF from OxiOrganosolv pretreated beechwood and pine was assessed by integrating a three-step process of enzymatic saccharification and isomerization followed by catalytic dehydration. The use of isobutanol in the pretreatment solvent and the addition of polyoxometallates (POMs) as oxidative catalysts were evaluated. The results showed that isobutanol leads to high delignification rates for both beechwood and pine, yielding cellulose-rich pulps with high susceptibility to enzymatic hydrolysis and isomerization. A fructose production up to 51.2 and 53.4 g/g of pretreated material was achieved for beechwood and pine, respectively, corresponding to 14 and 11.3 g of HMF/g of pretreated material. Regarding the use of POMs, the commercially available phosphomolybdic acid (HPMO) and POMs modified with oxidation metals (Fe-PMO, Cu-PMO) were tested, verifying their beneficial effect to lignin depolymerization and the composition of the final pulp. Hydrolysates produced from HPMo and Cu-PMo-assisted OxiOrganosolv pretreatment were efficiently used for the production of HMF, while severe inhibition of the dehydration reaction was observed with the hydrolysates from Fe-PMo pretreated biomass due to the presence of residual metals. This is the first systematic report comparing two lignocellulosic materials subjected to different pretreatment conditions for their potential to produce fructose and, subsequently, HMF.
Using the Animal Health and Welfare Pathway to engage with smaller pig producers
Authors: Siviter Peter 
Published: May 2024

This article looks at how to reach out to pig farmers using the new Animal Health and Welfare Pathway. This format gives veterinarians the scope to cover many aspects of pig health and welfare, and specifically to discuss porcine reproductive and respiratory syndrome (PRRS) (also known at ‘blue ear’), helping to control a serious disease and foster a more rewarding relationship with our pig clients. The information applies to all pig farms, but it is particularly directed towards vets who are not specialists and who, like this author, see generally smaller pigs holdings as part of their farm or mixed practice. Important points covered include: What is the ‘Animal Health and Welfare Pathway’? What is PRRS? How to practically carry out an Animal Health and Welfare Pathway review Helpful areas of discussion within a review meeting Likely future changes to the pathway review process.
Enhanced agency and the visual thinking of design
Authors: Mendoza-Collazos Juan 
Published: May 2024

Abstract
Visual thinking is a systematic way to produce knowledge in design by means of mental imagery, spatial reasoning, and the use of an array of visual representations. Pictorial representations such as sketches are crucial for the activity of designing at the early stage of the creative process. Designers see more information in sketches than was actually drawn. The ability to see more information than is sketched out can be seen as an enhanced visual capacity of human agency. Enhanced agency is the prosthetic incorporation of artifacts to improve the original agentive capacities. The incorporation of artifacts to draw raises some fundamental questions: Is the pencil an extension of the mind? Can we think with our hands? What agentive capacities are increased with the use of the pencil? What is the representational status of sketching? The chapter is structured around these key questions to suggest some answers inspired by the work of Göran Sonesson. Using the notion of enhanced agency and the layered model of agency, I explore the way in which the pencil improves the visual thinking of design. In doing so I found that it is important to maintain the principle of asymmetry in cognitive systems to reconsider relational ontology in favor of ecological relationships.
Divisia Monetary Aggregates for India
Authors: Sengupta Anirban , Serletis Apostolos , Xu Libo 
Published: May 2024

Abstract
In this paper, we are motivated by the fast growing literature that investigates the performance of Divisia monetary aggregates. We construct Divisia monetary aggregates for India using monthly data form January 2001 to March 2020 and present a comprehensive comparison across the Indian Divisia monetary aggregates at four levels of monetary aggregation, M1, M2, M3, and M4. We do so in the context of three classes of empirical models. In particular, we compute correlations between the cyclical components of the Divisia monetary aggregates and the cyclical component of the industrial production index. We test for Granger causality running from the Divisia monetary aggregates to industrial production. We also test for time-varying Granger causality. We find that the levels of the Divisia monetary aggregates Granger cause economic activity in India during normal times, but the causal link broke during and in the aftermath of the extremely unusual circumstances of the Covid-19 crisis.
Frequency of lymph node metastasis in differentiated thyroid carcinoma
Authors: Shahrear M. Khaled , Haque Muhammad M. , Iqbal Ashik , Khatun M. Romena , Nafis Ali A. M. 
Published: May 2024

Background: Although lymphatic metastasis does not affect overall survival for patients with differentiated thyroid carcinoma, locoregional control can be improved with cervical lymphadenectomy. The major morbidity of neck dissection (ND) for the management of regional metastasis is spinal accessory (CN XI) dysfunction. To avoid this complication, some surgeon advocates limited ND. This study aimed to analyze the frequency of lymph node metastasis in differentiated carcinoma of the thyroid.
Methods: This cross-sectional observational study was conducted at the Department of Otolaryngology, Rajshahi Medical College Hospital, Rajshahi, and Department of Otolaryngology, Bangabandhu Sheikh Mujib Medical University (BSMMU), from July 2011 to Jun 2012. A total of 40 patients were selected as study subjects by simple random sampling technique. A descriptive analysis of data was carried out by using a statistical package for social science (SPSS) 22.0 for Windows.
Results: In this study, a majority 35 (87.5%) of the patients suffered from papillary carcinoma, followed by 5 (12.5%) follicular carcinoma It was found that 18 (51.43%) patients had lymph node metastasis from papillary carcinoma of the thyroid. 10 (55.56%), and 4 (22.22%) patients had right and left-sided lymph node involvement respectively. Bilateral involvement was found in 4 (22.22%) patients. The predominant site of metastasis was level-III (77.3%) followed by level-VI (63.64%) nodal metastasis.
Conclusions: This study concludes that metastasis in differentiated thyroid carcinoma is common. Lymph node metastasis is more common in papillary carcinoma than follicular carcinoma.
Inequality in the appropriation of wealth generated between the richest and poorest municipalities in Brazil between 1999 and 2020
Authors: Arruda Vitoria Maria Oliveira , Silva Vitoria Biana da , Lemos Jose de Jesus Sousa , Reis Jose Newton Pires , Filho Joao Costa , Feitosa Milena Monteiro 
Published: May 2024

This research aimed to show the evolution of the Gross Domestic Product (GDP) per capita of the poorest Brazilian municipalities, in relation to that observed in the country's richest municipalities in the period 1999-2020. The data used were: total GDPs; GDP per capita; and agricultural GDP. The data source was the Brazilian Institute of Geography and Statistics (IBGE). We indexed all values for 2020 using the General Price Index (GPI) of the Getúlio Vargas Foundation. Brazil's 5,570 municipalities were ranked in ascending order using annual GDP per capita, and organized into deciles. We selected the first decile, which included the 557 municipalities with the lowest GDP per capita, and the last decile, which included the 557 municipalities with the highest GDP per capita, for comparison purposes. We evaluated the evolution of the per capita GDP/total GDP ratio in these deciles. Geometric Growth Rates (GGR) were estimated in order to gauge the trends observed in these ratios between 1999-2020. The evidence showed that the magnitudes of GDP per capita observed in the tenth and first deciles are quite unequal. However, the study also showed that there was a small reduction in the evolution of the GDP per capita/total GDP between 1999-2020, which suggests a small reduction in inequality in the appropriation of wealth generated in Brazil over the period evaluated. It was also observed that in the richest deciles, the agricultural GDP/total GDP ratio was lower than that observed in the poorest deciles.
OPTIMALISASI PENDIDIKAN AGAMA ISLAM DI SEKOLAH MELALUI PENGEMBANGAN BUDAYA RELIGIUS (Studi pada SMK Darul Ulum Bungbungan Bluto Sumenep)
Authors: Laisa Emna 
Published: May 2024

Artikel ini mendeskripsikan upaya SMK Darul Ulum dalam mengembangkan budaya religius di sekolah. Dengan menggunakan pendekatan kualitatif dan studi kasus, diketahui bahwa pengembangan budaya religius dilakukan di sekolah, di luar sekolah bersama warga, dan terhadap lingkungan/alam. Strategi pengembangan budaya religius dilakukan dengan cara merekrut guru lokal, menyemarakkan kegiatan keagamaan di luar kegiatan rutin sekolah, pelibatan guru untuk mengawasi praktik budaya religius, menjadikan kegiatan keagamaan sebagai kegiatan wajib, menggunakan metode pembelajaran yang menarik, pemberlakuan absensi siswa, dan penggunaan simbol-simbol budaya sebagai penguat. Faktor pendukung dalam pengembangan budaya religius adalah dukungan dari warga sekolah, orang tua, dan tokoh masyarakat. Sedangkan faktor penghambatnya adalah lingkungan sosial yang tidak kondusif dan pengaruh negatif iptek. Dampak positif budaya religius bagi siswa di SMK Darul Ulum, yaitu memupuk sikap istiqamah dalam beribadah, membentuk generasi Islam yang berjiwa pemimpin, menjadi wadah pengembangan bakat, serta meminimalisasi berbagai bentuk kenakalan re
KEBIJAKAN SEKOLAH DALAM PENGEMBANGAN MUTU PENDIDIKAN AGAMA ISLAM DI SMPN 1 OMBEN SAMPANG DAN SMPN 2 PAMEKASAN
Authors: Sahlan Moh 
Published: May 2024

Artikel ini mendeskripsikan kebijakan sekolah pengem­bangan mutu PAI, khususnya di SMPN 1 Omben Sampang dan SMPN 2 Pamekasan. Dengan menggunakan pendekatan kualitatif dan studi studi kasus, diketahui bahwa pertama; Proses perumusan kebijakan sekolah dalam pengembangan mutu PAI di SMPN 1 Omben Sampang menggunakan pedekatan school based sedangkan di SMPN 2 Pamekasan menggunakan pendekatan home based, Kedua; imple­mentasi kebijakan sekolah dalam pengembangan mutu PAI baik di SMPN 1 Omben Sampang dan SMPN 2 Pamekasan sama-sama berjalan efektif, bedanya di SMPN 1 Omben dilaksanakan di luar jam efektif sedangkan di SMPN 2 Pamekasan dilaksanakan di luar dan di dalam jam efektif, ketiga; evaluasi kebijakan sekolah dalam pengem­bangan mutu PAI di dua sekolah tersebut sama-sama dilakukan secara terus-menerus dan berkesinambungan untuk menjamin mutu PAI.
Simultaneous Determination of Isoniazid and Pyridoxine Hydrochloride in Tablet Dosage Forms using Ratio Subtraction Spectrophotometry
Authors: Tarigan Rida Evalina , Mendrofa Ester Lince Fiani , Surbakti Chemayanti 
Published: May 2024

<p>The study focused on the simultaneous quantification of Isoniazid (INH) and Pyridoxine Hydrochloride (PRD) in tablet form, commonly used in antituberculosis treatments. Assessing the accurate concentration of both INH and PRD in tablets is vital to ensure their effectiveness, safety, and quality. Using the ratio subtraction spectrophotometry method, the study analyzed INH and PRD in Pehadoxin forte® tablets (batch no. 36057007, PT. Phapros, Indonesia), with 0.1 N HCl as the solvent. The method involved obtaining ratio absorption spectra by dividing the absorption spectra of INH and PRD, respectively, to derive zero-order spectra for each drug. Method validation parameters included linearity, accuracy, precision, Limit of Detection (LOD), and Limit of Quantification (LOQ). The results showed linearity values of 0.9985 for INH and 0.9988 for PRD. Accuracy was 98.1838% for INH and 100.0205% for PRD, while precision was 1.8769% for INH and 0.2037% for PRD. LOD and LOQ for INH were 0.8116 µg/mL and 2.7053 µg/mL, respectively, and for PRD, 1.3127 µg/mL and 4.3757 µg/mL. The levels of INH and PRD in the tablets were found to be 102.1157% and 101.3874%, aligning with the Indonesian Pharmacopoeia's standards. This methodological approach provides a reliable analytical tool for the simultaneous assessment of INH and PRD in tablets, potentially extendable to other drug combinations and formulations, thereby contributing to pharmaceutical quality control processes. </p>
Setaman flower lexicons in the Nyekar rite: Anthropolinguistics of Javanese society
Authors: Salamah Salamah , Nazilah Halimah Milladunka , Agistina Fanya Indah , Zakiyah Millatuz 
Published: May 2024

The tradition of carrying setaman flowers in the nyekar rite success to be a part of local wisdom that has survived through various periods, but on the other hand, documents about it are still limited. This study aims to describe the lexicons in kembang setaman in the nyekar rite from the Javanese perspective. Adopting qualitative method with a focus on ethnographic approach, data is collected through interview and literature study and examined using semiotic and lexical-semantic analysis. The result show seven plants that make up the setaman, including (1) roses (mawar or mawi-arsa, a sincere intention to live up to noble values), (2) jasmine (melati or melat ing ati, the sincerity of the heart), (3) white chrysolite flower (kanthil or tansah kumanthil-kanthil, uninterrupted devotion), (4) ylang (kenanga or kenangen ing angga, always remembering the ancestral heritage), (5) tuberose (sedap malam or harum dhalu, always remembering the sacred teachings of the ancestors even in the dark of the night), (6) rose balsam (pacar air or pacar banyu, prosperity continues to flow), and (7) pandan leaves (liaison with the deceased). Kembang setaman functions as a symbol of gifts accompanied by prayers sent when visiting graves which are considered homes for people who have died, and contemporary Javanese society is still carrying out this tradition. This research expands the limited field of Anthropolinguistics studies, and on the other hand, can be used as cultural documentation that encourages the intention to better conserve the local wisdom over a long period.
Development of Interoperable Computable Phenotype Algorithms for Adverse Events of Special Interest to Be Used for Biologics Safety Surveillance: Validation Study
Authors: Holdefer Ashley A , Pizarro Jeno , Saunders-Hastings Patrick , Beers Jeffrey , Sang Arianna , Hettinger Aaron Zachary , Blumenthal Joseph , Martinez Erik , Jones Lance Daniel , Deady Matthew , Ezzeldin Hussein , Anderson Steven A 
Published: May 2024

Background
Adverse events associated with vaccination have been evaluated by epidemiological studies and more recently have gained additional attention with the emergency use authorization of several COVID-19 vaccines. As part of its responsibility to conduct postmarket surveillance, the US Food and Drug Administration continues to monitor several adverse events of special interest (AESIs) to ensure vaccine safety, including for COVID-19.

Objective
This study is part of the Biologics Effectiveness and Safety Initiative, which aims to improve the Food and Drug Administration’s postmarket surveillance capabilities while minimizing public burden. This study aimed to enhance active surveillance efforts through a rules-based, computable phenotype algorithm to identify 5 AESIs being monitored by the Center for Disease Control and Prevention for COVID-19 or other vaccines: anaphylaxis, Guillain-Barré syndrome, myocarditis/pericarditis, thrombosis with thrombocytopenia syndrome, and febrile seizure. This study examined whether these phenotypes have sufficiently high positive predictive value (PPV) to ensure that the cases selected for surveillance are reasonably likely to be a postbiologic adverse event. This allows patient privacy, and security concerns for the data sharing of patients who had nonadverse events can be properly accounted for when evaluating the cost-benefit aspect of our approach.

Methods
AESI phenotype algorithms were developed to apply to electronic health record data at health provider organizations across the country by querying for standard and interoperable codes. The codes queried in the rules represent symptoms, diagnoses, or treatments of the AESI sourced from published case definitions and input from clinicians. To validate the performance of the algorithms, we applied them to electronic health record data from a US academic health system and provided a sample of cases for clinicians to evaluate. Performance was assessed using PPV.

Results
With a PPV of 93.3%, our anaphylaxis algorithm performed the best. The PPVs for our febrile seizure, myocarditis/pericarditis, thrombocytopenia syndrome, and Guillain-Barré syndrome algorithms were 89%, 83.5%, 70.2%, and 47.2%, respectively.

Conclusions
Given our algorithm design and performance, our results support continued research into using interoperable algorithms for widespread AESI postmarket detection.