bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cisplatin Affects the Conformation of Apo Form, not Holo Form, of BRCA1 RING Finger Domain and Confers Thermal Stability
Authors: Atipairin Apichart , Canyuk Bhutorn , Ratanaphan Adisorn 
Published: August 2010

AbstractThe breast cancer suppressor protein 1 (BRCA1) has been shown to participate in genomic integrity maintenance. Preclinical and clinical studies have recently revealed that the inactivation of BRCA1 in cancer cells leads to chemosensitivity. Approaching the BRCA1 RING protein as a potentially molecular target for a platinum‐based drug might be of interest in cancer therapy. In the present study, the in vitro platination of the BRCA1 RING protein by the anticancer drug cisplatin was observed. The protein contained a preformed structure in the apo form with structural changes and resistance to limited proteolysis after Zn2+ binding. SDS‐PAGE and mass‐spectrometric analyses revealed that cisplatin preferentially formed monofunctional and bifunctional BRCA1 adducts. Tandem mass spectrometry (MS/MS) of the 656.292+ ion indicated that the ion arose from [Pt(NH3)2(OH)]+ bound to the BRCA1 peptide 111ENNSPEHLK119. The product‐ion spectrum revealed the Pt‐binding site on His117. Circular dichroism showed that the apo form, not holo form, of BRCA1 underwent more folded structural rearrangement upon cisplatin binding. Cisplatin‐bound protein exhibited an enhanced thermostability by 13°, resulting from the favorably intermolecular cross‐links driven by the free energy. Our findings demonstrated the first conformational and thermal evidences for a direct binding of cisplatin to the BRCA1 RING domain and could raise a possibility of selectively targeted treatment of cancer with less toxicity or improved response to conventional regimens.
Antituberculosis Agents and an Inhibitor of the para‐Aminobenzoic Acid Biosynthetic Pathway from Hydnocarpus anthelminthica Seeds
Authors: Wang Jun‐Feng , Dai Huan‐Qin , Wei Yu‐Ling , Zhu Hua‐Jie , Yan Yong‐Ming , Wang Yue‐Hu , Long Chun‐Lin , Zhong Hui‐Min , Zhang Li‐Xin , Cheng Yong‐Xian 
Published: August 2010

AbstractInvestigation on the extracts of Hydnocarpus anthelminthica seeds led to the isolation of three new compounds, anthelminthicins A–C (1–3, resp.), and two known ones, namely chaulmoogric acid (4) and ethyl chaulmoograte (5). Their structures were determined mainly by using spectroscopic techniques. The absolute configuration at the cyclopentenyl moiety of compound 2 was rationalized by quantum calculations. Base hydrolysis, followed by optical‐rotation comparison, allowed assignment of the configuration of chaulmoogric‐acid moiety of compounds 3 and 5. Biological assays revealed that compounds 1–5 significantly inhibit Mycobacterium tuberculosis (MTB) growth with MIC values of 5.54, 16.70, 4.38, 9.82, and 16.80 μM, respectively. Compound 3 was found to inhibit the pathway between chorismate and para‐aminobenzoic acid (pAba) with a MIC value of 11.3 μM, representing a new example of pAba inhibitor isolated from a natural source. All compounds were not toxic to Candida albicans SC5314 at a concentration up to 100 μM.
ChemInform Abstract: Millimeter‐Wave Spectrum of Nitrosyl Bromide in the Low‐Lying Excited States: Equilibrium Structure and Cubic Force Field.
Authors: DEGLI ESPOSTI C. , TAMASSIA F. , CAZZOLI G. , KISIEL Z. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Effect of Pt/Al2O3 Catalyst Preparation Conditions Upon Its Activity in Nitric Oxide Reduction.
Authors: SVORONOS D. G. , GRIGOROPOULOU H. P. , PHILIPPOPOULOS C. J. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Tl2O3×n H2O Nano‐Layers by Ionic Lamination on Silica Surfaces.
Authors: TOLSTOI V. P. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 1,2‐Stereoinduction in β‐Oxy‐Radicals: The Influence of the . alpha.‐Substituent.
Authors: GIESE B. , BULLIARD M. , DICKHAUT J. , HALBACH R. , HASSLER C. , HOFFMANN U. , HINZEN B. , SENN M. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: β‐Oxy‐α‐Diazo Carbonyl Compounds. Part 4. Reaction with Triethyl Borane. The Influence of the Oxy Group in the Regio‐ and Stereocontrolled Alkylation on the Diazo Carbon.
Authors: LOPEZ‐HERRERA F. J. , SARABIA‐GARCIA F. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Transfer of the Arylazo Group from 5‐Arylazo‐1,2,3,4,5‐ pentamethoxycarbonylcyclopentadienes to Nucleophilic Carbon Centers.
Authors: DUSHENKO G. A. , SKACHKOV R. V. , MIKHAILOV I. E. , DIVAEVA L. N. , MINKIN V. I. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 1,2‐Di(lithiomethyl)benzene from Phthalan: Sequential Introduction of Two Different Electrophiles.
Authors: ALMENA J. , FOUBELO F. , YUS M. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: DTBB‐Catalyzed Lithiation of 2,3‐Dichloropropene and Related Chloroamines: Synthetic Applications.
Authors: HUERTA F. F. , GOMEZ C. , GUIJARRO A. , YUS M. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Diastereoselective Addition of Organometallic Reagents to Norephedrine‐ Derived 2‐Acyl‐N‐tosyloxazolidines.
Authors: POLI G. , MACCAGNI E. , MANZONI L. , PILATI T. , SCOLASTICO C. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Preparation of β‐Oxoester Enolate Equivalents from SmI2 and . alpha.‐Bromoalkanoates.
Authors: UTIMOTO K. , MATSUI T. , TAKAI T. , MATSUBARA S. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New, Efficient Method for the Synthesis of Allyltitanium Compounds from Allyl Halides or Allyl Alcohol Derivatives via Oxidative Addition. A Highly Efficient and Practical Synthesis of Homoallyl Alcohols.
Authors: KASATKIN A. , NAKAGAWA T. , OKAMOTO S. , SATO F. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Silyl Enol Ethers in Paterno‐Buechi Reactions. Functional Group Tolerance and the Effect of β‐Alkyl Substitution.
Authors: BACH T. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reaction of 1,1,1‐Trifluoro‐2‐diazo‐3‐nitropropane with Enamines of Ketones.
Authors: AIZIKOVICH A. YA. , KOROTAEV V. YU. , YAROSLAVTSEVA L. E. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Scope of the Chromium(II)‐Mediated Synthesis of E‐Alkenylstannanes from Aldehydes and Bu3SnCHBr2.
Authors: HODGSON D. M. , BOULTON L. T. , MAW G. N. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Tandem Sequence of ArSCl Initiated AdE Reactions Resulting in Formation of Two C‐C Bonds.
Authors: SMOLIAKOVA I. P. , CAPLE R. , MAGNUSON V. R. , POLYAKOV V. R. , SMIT W. A. , SHASHKOV A. S. , OHINOV B. D. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Transesterification Catalyzed by Lanthanoid Tri‐2‐propoxides.
Authors: OKANO T. , MIYAMOTO K. , KIJI J. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Tandem Insertion of Lithium Chloroallylide and Aldehydes into Zirconacyclopentenes.
Authors: GORDON G. J. , WHITBY R. J. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemistry of Nitroesters. Part 17. Synthesis of Mesoxalic Acid Esters.
Authors: KOCHERGIN P. M. , TITKOVA R. M. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Improved Preparation of Diphenylmethylenecyclopropanes and Their Use in Intramolecular Palladium Catalyzed (3 + 2) Cycloadditions.
Authors: LEWIS R. T. , MOTHERWELL W. B. , SHIPMAN M. , SLAWIN A. M. Z. , WILLIAMS D. J. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Fluorocyclization of Unsaturated Aldehydes to Five‐ or Six‐Membered Cyclic Fluoroalcohols.
Authors: HAYASHI E. , HARA S. , SHIRATO H. , HATAKEYAMA T. , FUKUHARA T. , YONEDA N. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Aryl Mesylates in Metal‐Catalyzed Homocoupling and Cross‐Coupling Reactions. Part 3. A Simple and General Method for the Synthesis of 2, 2′‐Diaroyl‐4,4′‐dihydroxybiphenyls.
Authors: PERCEC V. , BAE J.‐Y. , ZHAO M. , HILL D. H. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Tandem Radical Cyclization in the Flash Vacuum Pyrolysis of 2‐ Methoxyphenyl and 2‐Methylthiophenyl Substituted Phosphorus Ylides.
Authors: AITKEN R. A. , BRADBURY C. K. , BURNS G. , MORRISON J. J. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Facile and Efficient Syntheses of Novel (S)‐ and (R)‐3‐ Fluoropyrrolidines and 3,3‐Difluoropyrrolidine.
Authors: GIARDINA G. , DONDIO G. , GRUGNI M. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthetic Study of the Highly Potent and Selective Anti‐Platelet Activating Factor Thiazolidin‐4‐one Agents and Related Compounds.
Authors: TANABE Y. , YAMAMOTO H. , MURAKAMI M. , YANAGI K. , KUBOTA Y. , OKUMURA H. , SANEMITSU Y. , SUZUKAMO G. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 3‐Heteroaryl‐2(1H)‐quinolones. Part 4. Some 4‐Hydroxy‐1‐ methyl‐3‐(5‐methyl‐3‐thioxo‐s‐triazolidin‐5‐yl)‐2(1H)‐quinolones and Related Compounds.
Authors: ISMAIL M. M. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 4,7‐Diphenyl‐2H,5H‐pyrano(4,3‐b)pyran‐2,5‐dione.
Authors: KOZ'MINYKH E. N. , IGIDOV N. M. , KOZ'MINYKH V. O. , BEREZINA E. S. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Facile, Regioselective Syntheses of N‐Alkylated 2,3‐Diaminopyridines and Imidazo(4,5‐b)pyridines.
Authors: KHANNA I. K. , WEIER R. M. , LENTZ K. T. , SWENTON L. , LANKIN D. C. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Syntheses and Properties of Halogenated EDT‐TTF Derivatives.
Authors: KUX U. , SUZUKI H. , SASAKI S. , IYODA M. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Heteroatom Photocyclization. Synthesis of New Pyrimido(1,2‐a) benzimidazole Derivatives.
Authors: FROLOV A. N. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: One‐Pot Synthesis of 7‐Phenoxy‐4H‐1,4‐benzothiazines.
Authors: ALABDALLA M. A. , GUPTA R. R. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation of Vinyl Tellurides via a Simplified Ylidation Reaction.
Authors: SILVEIRA C. C. , PERIN G. , BRAGA A. L. , PETRAGNANI N. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Synthesis of an Oxa‐Taxane Derivative via Tandem Intramolecular (2 + 2) Cycloaddition and (3,3)‐Sigmatropic Rearrangement of Allenyl Ether.
Authors: YEO S.‐K. , HATAE N. , SEKI M. , KANEMATSU K. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Use of Acyclic Monoterpenes in the Preparation of β‐Pyrones: Synthesis of the Right‐Hand Fragment of Usneoidone E.
Authors: URONES J. G. , DIEZ D. , MARCOS I. S. , BASABE P. , LITHGOW A. M. , MORO R. F. , GARRIDO N. M. , ESCARCENA R. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Asymmetric Synthesis of Fully Functionalized B Ring System of Taxol.
Authors: SHIINA I. , UOTO K. , MORI N. , KOSUGI T. , MUKAIYAMA T. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 6α,7α‐ and 6β,7β‐Aziridinoandrost‐4‐ ene‐3,17‐diones and Related Compounds: Potential Aromatase Inhibitors.
Authors: NJAR V. C. O. , HARTMANN R. W. , ROBINSON C. H. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Sphingosines. Part 11. Convenient Synthesis of Phytosphingosine and Sphinganine from D‐Galactal and D‐Arabitol.
Authors: WILD R. , SCHMIDT R. R. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Iminophosphorane‐Mediated Synthesis of the Carbon Skeleton of the Azafluoranthene Alkaloids Rufescine and Imeluteine.
Authors: MOLINA P. , GARCIA‐ZAFRA S. , FRESNEDA P. M. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Thiocarbamates as Novel Backbone Analogues in Oligonucleotides.
Authors: WALDNER A. , DE MESMAEKER A. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 4,5,8‐trimethoxy‐9,10‐dioxo‐9,10‐dihydroanthracene‐2‐ carboxylic Acid, an Analogue of Rhein with Improved Systemic Exposure in the Guinea Pig.
Authors: OWTON W. M. , BRUNAVS M. , MILES M. V. , DOBSON D. R. , STEGGLES D. J. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.