bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facile aqueous synthesis of functionalized CdTe nanoparticles and their application as fluorescence probes for determination of adenine and guanine
Authors: Li Li , Lu Yaxiang , Ding Yaping , Zhang Fenfen , Wang Yaping 
Published: January 2012

Thioglycolic acid (TGA)-capped CdTe nanoparticles (NPs) were synthesized in aqueous medium, and their application as fluorescence probes in the detection of adenine and guanine was studied. The TGA-capped CdTe NPs were characterized by transmission electron microscopy, X–ray diffraction spectrometry, spectrofluorometry, Fourier transform infrared, and ultraviolet-visible spectrometry. Based on the significant enhancement of fluorescence emission of these CdTe fluorescence probes in the presence of adenine or guanine, a quantitative analysis method for these purines was proposed. Experimental conditions that govern the extent of fluorescence enhancement were optimized. Under the optimal conditions, the relative fluorescence intensity versus adenine or guanine concentrations gave a linear response, permitting the dynamic range of 7.0 × 10−7–1.0 × 10−4 mol/L and 6.0 × 10−7–9.0 × 10−5 mol/L for adenine and guanine, respectively. The method has also been applied successfully to the detection of adenine and guanine in synthetic samples with satisfactory results.
p53 Inhibits Angiogenesis by Inducing the Production of Arresten
Authors: Assadian Sarah , El-Assaad Wissal , Wang Xue Q.D. , Gannon Phillipe O. , Barrès Véronique , Latour Mathieu , Mes-Masson Anne-Marie , Saad Fred , Sado Yoshikazu , Dostie Josée , Teodoro Jose G. 
Published: January 2012

Abstract
Several types of collagen contain cryptic antiangiogenic noncollagenous domains that are released upon proteolysis of extracellular matrix (ECM). Among those is Arresten, a collagen-derived antiangiogenic factor (CDAF) that is processed from α1 collagen IV. However, the conditions under which Arresten is released from collagen IV in vivo or whether the protein functions in tumor suppressor pathways remain unknown. Here, we show that p53 induces the expression of α1 collagen IV and release of Arresten-containing fragments from the ECM. Comparison of the transcriptional activation of COL4A1 with other CDAF-containing genes revealed that COL4A1 is a major antiangiogenic gene induced by p53 in human adenocarinoma cells. p53 directly activated transcription of the COL4A1 gene by binding to an enhancer region 26 kbp downstream of its 3′ end. p53 also stabilized the expression of full-length α1 collagen IV by upregulation of α(II) prolyl-hydroxylase and increased the release of Arresten in the ECM through a matrix metalloproteinase (MMP)-dependent mechanism. The resulting upregulation of α1 collagen IV and production of Arresten by the tumor cells significantly inhibited angiogenesis and limited tumor growth in vivo. Furthermore, we show that immunostaining of Arresten correlated with p53 status in human prostate cancer specimens. Our findings, therefore, link the production of Arresten to the p53 tumor suppressor pathway and show a novel mechanism through which p53 can inhibit angiogenesis. Cancer Res; 72(5); 1270–9. ©2012 AACR.
KR-POK Interacts with p53 and Represses Its Ability to Activate Transcription of p21WAF1/CDKN1A
Authors: Jeon Bu-Nam , Kim Min-Kyeong , Choi Won-Il , Koh Dong-In , Hong Sung-Yi , Kim Kyung-Sup , Kim Minjung , Yun Chae-Ok , Yoon Juyong , Choi Kang-Yell , Lee Kyung-Ryul , Nephew Kenneth P. , Hur Man-Wook 
Published: January 2012

Abstract
Transcriptional regulation by p53 is thought to play a role in its ability to suppress tumorigenesis. However, there remain gaps in understanding about how p53 regulates transcription and how disrupting this function may promote cancer. Here we report a role in these processes for the kidney cancer–related gene KR-POK (ZBTB7C), a POZ domain and Krüppel-like zinc finger transcription factor that we found to physically interact with p53. Murine embryonic fibroblasts isolated from genetically deficient mice (Kr-pok−/− MEFs) exhibited a proliferative defect relative to wild-type mouse embryonic fibroblasts (MEF). The zinc finger domain of Kr-pok interacted directly with the DNA binding and oligomerization domains of p53. This interaction was essential for Kr-pok to bind the distal promoter region of the CDKN1A gene, an important p53 target gene encoding the cell-cycle regulator p21WAF1, and to inhibit p53-mediated transcriptional activation of CDKN1A. Kr-pok also interacted with the transcriptional corepressors NCoR and BCoR, acting to repress histone H3 and H4 deacetylation at the proximal promoter region of the CDKN1A gene. Importantly, Kr-pok−/− MEFs displayed an enhancement in CDKN1A transactivation by p53 during the DNA damage response, without any parallel changes in transcription of either the p53 or Kr-pok genes themselves. Furthermore, Kr-pok promoted cell proliferation in vitro and in vivo, and its expression was increased in more than 50% of the malignant human kidney cancer cases analyzed. Together, our findings define KR-POK as a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. Cancer Res; 72(5); 1137–48. ©2012 AACR.
Human TH17 Immune Cells Specific for the Tumor Antigen MAGE-A3 Convert to IFN-γ–Secreting Cells as They Differentiate into Effector T Cells In Vivo
Authors: Hamaï Ahmed , Pignon Pascale , Raimbaud Isabelle , Duperrier-Amouriaux Karine , Senellart Hélène , Hiret Sandrine , Douillard Jean-Yves , Bennouna Jaafar , Ayyoub Maha , Valmori Danila 
Published: January 2012

Abstract
The role of TH17 cells in cancer is being investigated, but the existence of tumor antigen–specific TH17 cells has yet to be ascertained. Here, we report the first description of a spontaneous TH17 (IL-17+) response to the important tumor antigen MAGE-A3, which occurred concurrently with a TH1 (IFN-γ+) response in a lung cancer patient. MAGE-A3–specific interleukin (IL)-17+ T cells were mainly CCR7+ central memory T cells, whereas IFN-γ+ cells were enriched for CCR7− effector memory T cells. An assessment of the fine specificity of antigen recognition by these T cells indicated that the CCR6+CCR4+ and CCR6+CXCR3+ fractions contained the same TH17/TH1 population at early and late differentiation stages, respectively, whereas the CCR6−CXCR3+ fraction contained a distinct TH1 population. These findings are important because they suggest a differentiation model in which tumor antigen–specific CD4+ T cells that are primed under TH17 polarizing conditions will progressively convert into IFN-γ–secreting cells in vivo as they differentiate into effector T cells that can effectively attack tumors. Cancer Res; 72(5); 1059–63. ©2012 AACR.
Reduced DICER1 Elicits an Interferon Response in Endometrial Cancer Cells
Authors: Chiappinelli Katherine B. , Haynes Brian C. , Brent Michael R. , Goodfellow Paul J. 
Published: January 2012

Abstract
DICER1 is essential for the generation of mature miRNAs and other short noncoding RNAs. Several lines of investigation implicate DICER1 as a tumor suppressor. Reduced DICER1 levels and changes in miRNA abundance have been associated with aggressive tumor phenotypes. The global effects of reduced DICER1 on mRNA transcript abundance in tumor cells remain largely unknown. We used short hairpin RNA to stably knock down DICER1 in endometrial cancer cell lines to begin to determine how reduced DICER1 activity contributes to tumor phenotypes. DICER1 knockdown did not affect cell proliferation but caused enhanced cell migration and growth in soft agar. miRNA and mRNA profiling in KLE cells revealed overall decreases in miRNA levels and changes in the relative abundance of many mRNAs. One of the most striking changes in mRNA levels was the upregulation of IFN-stimulated genes (ISG), the majority of which lack known miRNA target sequences. IFNβ, a key upstream regulator of the IFN response, was significantly increased in DICER1 knockdowns in the AN3CA, Ishikawa, and KLE endometrial cancer cell lines and in the normal endometrial cell line EM-E6/E7/TERT. IFNβ secreted in media from KLE and EM-E6/E7/TERT shDcr cells was sufficient to activate an IFN response in HT29 cells. The reduced miRNA processing in DICER1 knockdowns was associated with increases in pre-miRNAs in the cytoplasm. Our findings suggest that elevated pre-miRNA levels trigger the IFN response to double-stranded RNA. We thus report a novel effect of reduced DICER1 function in cancer cells. Mol Cancer Res; 10(3); 316–25. ©2012 AACR.
Bare Metal Stent Thrombosis and In-Stent Neoatherosclerosis
Authors: Yamaji Kyohei , Inoue Katsumi , Nakahashi Takuya , Noguchi Masahiko , Domei Takenori , Hyodo Makoto , Soga Yoshimitsu , Shirai Shinichi , Ando Kenji , Kondo Katsuhiro , Sakai Koyu , Iwabuchi Masashi , Yokoi Hiroyoshi , Nosaka Hideyuki , Nobuyoshi Masakiyo , Kimura Takeshi 
Published: January 2012

Background—
Very late stent thrombosis (VLST) was reported to occur even in patients with bare metal stent (BMS) implantation, although the annual incidence of VLST after BMS was much lower than that after drug-eluting stent implantation. Pathophysiologic mechanisms of VLST after BMS implantation remain largely unknown.

Methods and Results—
From September 2002 to February 2010, we identified 102 patients with definite stent thrombosis (ST) of BMS and 42 control patients with acute coronary syndrome (ACS) unrelated to ST who underwent thrombus aspiration with histopathologic evaluation. There were 40 patients with early ST (EST, within 30 days), 20 patients with late ST (LST, between 31–365 days), and 42 patients with VLST (>1 year). Evidence for fragments of atherosclerotic plaques, such as foamy macrophages, cholesterol crystals, and thin fibrous cap, was more commonly seen in patients with EST (23%) and VLST (31%), whereas these findings were rarely observed in patients with LST (10%). Atherosclerotic fragments were predominantly seen in patients who had EST within 7 days or VLST beyond 3 years. The aspirated thrombi harvested from patients with ST and those with ACS were histologically indistinguishable from each other. Eosinophils were very rarely observed. Plasma level of total cholesterol and triglyceride were significantly higher in VLST cases with atherosclerotic fragments as compared with those without.

Conclusions—
Fragments of atherosclerotic plaque were highly prevalent in patients with VLST beyond 3 years. Disruption of in-stent neoatherosclerosis could play an important role in the pathogenesis of VLST of BMS occurring beyond 3 years after implantation.
Cultural Politics of Representation in Contemporary Indonesia
Authors: Schlehe Judith 
Published: January 2012

AbstractThe organisation and representation of diversity is a crucial challenge for all countries and especially for post-colonial nations. Accordingly, the politics of multiethnic representation as well as multicultural rhetoric is constantly reformulated and adapted to new conditions, both locally and globally.Cultural theme parks are a typical arena for the display of multiculturality. In the case of Indonesia it is of special interest to investigate whether and in what ways the public staging of ethnic cultures has changed in the reform era (since 1998). This includes aspects of inclusion and exclusion. Which ethnic groups are defined as being constitutive for the Indonesian nation and how are they represented in the central theme park, Taman Mini, in Jakarta? In which ways are the political processes of democratisation and decentralisation reflected in the organisation of Taman Mini, which used to be a main icon of Suharto's New Order regime?This paper suggests that there is a need for Indonesia to re-imagine itself and to refashion a globally oriented multicultural—or, even better, transcultural—identity for the future. Popular public spaces like cultural theme parks have the potential to be appropriate places for such innovative visions.
China and the Iranian Nuclear Crisis: Between Ambiguities and Interests
Authors: Djallil Lounnas 
Published: January 2012

AbstractThis article analyses, the complex relationship between Tehran, Beijing and Washington on the Iranian nuclear issue. Indeed, China's policy towards Iran has often been described as ambiguous, in supporting Washington, on the one hand, while protecting Tehran, on the other hand. In this article, we argue that, in fact, Beijing policy vis-a-vis Tehran depends on the state of its relationships with Washington. Indeed, a closer analysis shows that China is using Iran as a bargaining chip with the United States on, among others, two key security issues, i.e., Taiwan and the oil supply. The guarantee of a secured oil supply from the Middle-East in addition to a comprehensive policy of the US with regard to Chinese security interests in Taiwan as well as the use of smart sanctions against Tehran, which would thus take into account, to a certain extent, Beijing economic interests in Iran, are, indeed, the guarantee of Beijing's support to the US policy towards Iran.
Japan–Taiwan Relations in the Twenty-First Century from the Perspective of Tuna Disputes in the Atlantic Ocean
Authors: Chen Henry 
Published: January 2012

AbstractOver the last decade bilateral relations between Japan and Taiwan have been strained over the issue of tuna fishery management. In 2005, when Taiwan was still under the Democratic Progressive Party (DPP) administration, Japan proposed punitive measures against Taiwan's tuna industries in an international fisheries management body for the Atlantic Ocean. The DPP government took a pragmatic approach, solving the tuna crisis without harming Japan–Taiwan relations, as evidenced by the fact that during the tuna disputes visa-free privilege was granted to Taiwan nationals and the Japanese government openly stated that Taiwan has been a main security objective for Japan and the US. In this paper the Japan-led tuna sanction in 2005 is used as a case study to gauge overall bilateral relations thus far in the twenty-first century.
Destabilizing the Semiperiphery: The Counterturn of China’s Ascendance in the World-Economy
Authors: Shie Vincent H. , Weng Chih-Yuan 
Published: January 2012

Abstract
In an article in Perspectives on Global Development and Technology (PGDT), Kwangkun Lee revisits the debate on whether the semiperiphery is persistent or short-lived in the long-term historical structure. Lee concludes that semiperipheries only have a brief lifespan due to their (assumed) polarizing tendency. We provisionally agree with Lee’s conclusion, but we diverge in our reasoning for upholding this hypothesis. Proponents of the World-Systems Theory claim that an intermediate group of states stabilizes the world-economy. For instance, Giovanni Arrighi posits that the semiperiphery will be persistent in the longue durée. But in our view, the rise of China will ultimately destabilize the so-called constant stratum of the semiperiphery.
Who Benefits from Market-Based Carbon Mitigation?
Authors: Bohr Jeremiah , Dill Brian 
Published: January 2012

Abstract
As world leaders increasingly recognize the dual imperatives of mitigating carbon emissions and ensuring economic growth, emissions trading schemes have become popular policy options to pursue sustainable development goals. As the foremost program of sustainable development to date, the Clean Development Mechanism (CDM) has held out hope that low-cost abatement in the global North could be achieved by channeling investments to the global South, creating a win-win situation of both mitigation and economic development. Unfortunately, the results of the CDM have shown an asymmetrical distribution of benefits in the global South despite contrary objectives. This paper argues that the investment climate promoted by the CDM excludes many developing nation markets from participation, thereby limiting one of the key benefits promised by CDM proponents. This is partly because the CDM encourages investors to seek projects that are doubly profitable, ones that demonstrate the potential to generate a profit independent of emissions credits, placing many nations at a structural disadvantage, as they are deemed too risky for sustainable development investment.
Communities in Disasters: Helpless or Helping?
Authors: Takazawa Aiko , Williams Kate 
Published: January 2012

Abstract
Development faces the challenge of an unexpected rise in disasters of all kinds. Prompted by two popular books about disasters (Klein 2007; Solnit 2009), we review the North American scholarly literature on disasters to answer three questions. Practically, how do local communities respond to disasters? Theoretically, what is the relationship between local social networks and disaster response/recovery? For policy, whom should we count on to carry this out? The primary finding is that communities, however devastated, are not helpless, but helping, and in particular stages. Outside social forces can help, but disregarding local networks and processes impedes disaster response/recovery.
Tertullian on Liturgical Prayer to Christ: New Insights from De Spect. 25.5 and Apol. 2.6
Authors: Paschke Boris A. 
Published: January 2012

Abstract
So far, scholarship on early Christian liturgical prayer to Christ has neglected two relevant texts of Tertullian: De Spect. 25.5 and Apol. 2.6. This article points out that both texts reflect Tertullian’s awareness and approval of the liturgical practice of addressing Christ in prayer. It is suggested that in the pre-Arian period, liturgical prayer to Christ was more accepted, prevalent, and established than is commonly held in scholarship.
Free Movement of Patients: Directive 2011/24 on the Application of Patients’ Rights in Cross-Border Healthcare
Authors: Peeters Miek 
Published: January 2012

Abstract
This contribution comments on Directive 2011/24, providing a legal framework for cross border healthcare 13 years after the famous Kohll and Decker case law. The Directive contains provisions concerning the reimbursement of costs, the responsibilities of the Member States and their mutual cooperation in healthcare. Analysing the (potential) impact of the Directive 2011/24 on EU healthcare systems, patients and healthcare providers, it becomes clear that the impact of the Directives reaches far beyond patient mobility. The Directive creates patients’ rights, pays attention to the quality and safety of healthcare services and creates an excessive structure of cooperation in the field of healthcare. The European Union seems ready to use its economies of scale to improve healthcare for all European patients.
Restrictions of the Sale of Pharmaceuticals and Medical Devices such as Contact Lenses over the Internet and the Free Movement of Goods
Authors: de Sadeleer Nicolas 
Published: January 2012

Abstract
In the light of new case law development, this article examines whether national restrictions on the on-line sale of pharmaceuticals and medical devices such as contact lenses are consistent either with EU secondary law, either with Article 34 TFEU that prohibits measures having equivalent effect to quantitative restrictions on imports. In particular, this article focuses on an analysis of two judgments on this important issue delivered by the Court of Justice of the European Union in 2003 and 2010, namely the Deutscher Apothekerverband decision and the Ker-Optika decision.
Protestant Worship with Chinese Characteristics: Reflections on a Chinese Worship Service
Authors: Selles Kurt D. 
Published: January 2012

Abstract
The article explores the latent impact of traditional Chinese culture on worship in one Three-Self Patriotic Movement Protestant church in a mid-sized, provincial city in central China. Employing a case study approach, the author visited the church under consideration numerous times over a several-year period and interviewed pastors, evangelists, and members about their worship services. The author’s conclusion is that subtle aspects of the Chinese tradition, and above all Confucianism, can be seen in the worship services of this church. Additionally, the author suggests that these influences can be seen in worship in provincial urban churches around the country and considers the probability and process of change taking place in their worship services.
In Search of Affirmed Aboriginality as Christian: “If you do not walk on the tracks of your grandparents, you will get lost . . .”
Authors: Hut Janneke 
Published: January 2012

Abstract
The marginalized position in which the Indigenous peoples of Australia find themselves today is undeniable. Within the tragedy of low life-expectancy, high rates of substance abuse, malnutrition, poor housing, high infant mortality, deaths in custody etc. lies a spiritual crisis. This crisis is aggravated by the circumstance that the loss of the land to the European invaders has caused a loss of Aboriginal identity. In their attempt to recover from this colonial legacy the Aborigines try to re-find their (religious) self-identity and to unite through Aboriginality. In this search for Aboriginal identity through spirituality and faith some Christian theologians explore the possibilities of an Aboriginal contextual theology as a response to this crisis.
Observed Antarctic Interannual Climate Variability and Tropical Linkages
Authors: Schneider David P. , Okumura Yuko , Deser Clara 
Published: January 2012

AbstractThis study reviews the mechanisms associated with Antarctic–tropical climate linkages and presents new analyses of the seasonality and spatial patterns of tropical climate signals in the Antarctic for the late 1950s to the present. Tropical climate signals are primarily communicated to the Antarctic via the Pacific–South America (PSA) pattern and the southern annular mode (SAM). The impacts of these circulation patterns and their tropical linkages are evident in regressions of seasonally stratified Antarctic station temperature data and annually resolved ice core records on global fields of sea surface temperature, sea level pressure, and precipitation. Temperature and ice core anomalies in the Antarctic Peninsula region and adjoining areas of West Antarctica are significantly impacted by the PSA, interpreted as a Rossby wave train driven by anomalous tropical deep convection during ENSO events. This pattern is most evident in the austral spring, consistent with recent studies, suggesting that atmospheric conditions for Rossby wave propagation are most favorable during this season. During austral summer at the peak of the ENSO cycle, temperature anomalies at East Antarctic coastal stations exhibit significant correlations with tropical Pacific anomalies. This linkage reflects the influence of anomalous tropical heating on the position and strength of the subtropical jets and is consistent with changes in eddy momentum fluxes that alter the mean meridional circulation associated with the SAM. Of the ice cores that exhibit tropical linkages, most tend to be associated with the PSA teleconnection. The implications of the study’s findings for understanding Antarctic climate variability and climate change from seasonal to decadal time scales are also discussed.