bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rare presentations of Sjogren syndrome
Authors: Shah Miet D. , Malik Atiullah I. , Gill Niharika H. , Ghiya Murtuza N. , Jain Ashish K. 
Published: April 2024

Sjögren’s syndrome is a chronic systemic autoimmune disease characterized by lymphocytic infiltration of exocrine glands. It most commonly presenting with sicca symptoms. Sicca refers to dryness most often involving the eyes and mouth due to inflammation and resultant pathology of the lacrimal and salivary glands. Up to one-half of affected individuals also develop extra-glandular involvement in organs such as the joints, skin, lungs, gastrointestinal (GI) tract, nervous system, and kidneys. This condition is frequently associated with other autoimmune disorders including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) - called the secondary Sjogrens syndrome. Evaluation of a patient with suspected Sjogren syndrome should include an evaluation of oral and ocular dryness and function. In addition to the history, this may include the performance of a Schirmer test, slit-lamp exam with vital dye staining, salivary flow rate, and/or nuclear scintigraphic evaluation of the salivary glandular function. Assessment of autoantibodies (ANA, RF, SS-A, and SS-B) should also be performed. Of these, SS-A is probably the most sensitive and specific antibody for Sjogren's but alone is not diagnostic since it may be present in other autoimmune disorders and may be absent in up to a third of Sjogren cases. The most specific single test is a minor salivary gland (lip) biopsy which will demonstrate focal lymphocytic sialadenitis (FLS). Therapies are directed toward replacing moisture at affected glandular sites and suppressing the autoimmune response locally as well as systemically. This activity reviews the evaluation and management of Sjogren syndrome and explains the different rare presentations in which it can present.
Identification of dental sexual dimorphism in deciduous teeth: A cross sectional study
Authors: Sankoung Soumboundou , Aziz Ayat Ben , Ndiaye Mamadou Lamine , Ndoye Soukeye 
Published: April 2024

The study of sex diagnosis is essential to reconstruct the biological profile of an unknown individual. Two approaches are often used: morphometric and scopic. This three-dimensional morphometric study aimed to assess sexual dimorphism in temporary dentition.: A total of 200 dental impressions digitized in 3D using the Revopoint® POP2 3D scanner were used for this odontometric analysis. Discriminant statistical analysis (Student's t-test) revealed that boys had higher mean values than girls for all distances measured. A highly significant sexual dimorphism was observed in the temporary second molars. The distance between the mandibular canines was slightly greater in boys, although this difference was not statistically significant. In conclusion, odontometric parameters are a simple, reliable, and inexpensive method of sex determination. The temporary canines and second molars are the most dimorphic.
Evaluation of adaptogenic and antidepressant activity of hydroalcoholic leaves extract of Salacia chinensis in mice
Authors: Raunakkumar Chaurasiya , Kamble Jayalalita , Kumar Yeshavantha , Chaurasiya Ankita 
Published: April 2024

Study was carried out to evaluate the Adaptogenic and Antidepressant effect of Salacia chinensis leaf extract in animal model.Salacia chinensis is a plant species belonging to the family Celastraceae. This study was carried out to evaluate the Adaptogenic and Antidepressant effect of Salacia chinensis leaf extract in animal model. Swimming Endurance Test was used to evaluate the Adaptogenic activity in albino mice while Tail Suspension Test and Elevated Plus Maze test was used to evaluate the Antidepressant activity in albino mice. In Swimming Endurance model various biochemical parameters like blood glucose, cholesterol, triglycerides were estimated, weight of organs like liver, spleen and adrenal gland was measured in stress control and extract treated animals. Immobility as behavioural parameter was assessed in Tail Suspension Test and Elevated Plus Maze model of depression after treatment with hydroalcoholic extract of Salacia chinensis leaf at selected dose of 200 mg/kg and 400 mg/kg. Results of the study have showed significant Adaptogenic and Antidepressant activity of Salacia chinensis.Preliminary Phytochemical Analysis (15) Salacia chinensis leaves extract was subjected to chemical tests for the identification of their active constituents. The results have indicated the presence of flavonoid, alkaloids, terpenoids, saponins, glycosides, carbohydrates.The biochemical estimation results obtained showed decrease in blood glucose, triglyceride, and slight increase in cholesterol level when compared to control which support the adaptogenic activity of the title plant as shown in table no: 02,03,04 and fig no: 03,04,05,06,07. The duration of immobility was reduced after treated with hydroalcoholic extract of Salacia chinensis and results are significant on both high dose 400 mg/kg, p.o. (P&#60;0.001) and low dose 200 mg/kg, p.o. (P&#60;0.01) with that of standard Imipramine (10 mg/kg, p.o.) indicating that the extract possess significant antidepressant activity. Results depicted in table no: 05 and fig no: 08,09.The hydroalcoholic extract of Salacia chinensis at high dose (400 mg/kg, p.o) (P˂0.05) significantly increased the number of entries in to open arm and total time spent in open arm as compared to control.It shows increase in the mobility of the mice in open arm which suggest the antidepressant activity shown in table no:06 and fig no: 10,11.Based on the results obtained from this study it can be concluded that the hydroalcoholic extract of Salacia chinensis leaves possess Adaptogenic and Antidepressant activity. This beneficial effect of Salacia chinensis leaf might be due to presence of flavonoids, alkaloids and its derivatives.
Main features of diagnosis and treatment of delirium in icu patients: a systematic review
Authors: Riabchenko M. A. , Leyderman I. N. 
Published: April 2024

Relevance. Delirium is a severe neuropsychiatric syndrome, which is a common problem in patients in the intensive care unit (ICU). Recently published works indicate a insufficiency of awareness about the key principles of diagnosis and treatment of this condition. The aim of the study is to analyze and summarize data on algorithms that allow the identification and correction of delirium in patients in the intensive care unit. Materials and methods. A comprehensive search was conducted in the electronic databases PubMed and eLIBRARY. The review includes searchable publications for May 2023. Results. A literature review identified five adult delirium screening tools that have been validated against The Diagnostic and Statistical Manual of Mental Disorders (DSM) diagnostic criteria for delirium. Prospects for improving clinical outcomes are multi-component programs with a large number of strategies aimed at assessing, preventing and treating delirium in the ICU. Conclusion. It is necessary to use validated screening tools, as well as implement preventive strategies such as ABCDEF. Prevention of delirium in the ICU by determining the level of risk, eliminating etiological development factors and early multimodal therapy should be included in the standard algorithm from the moment the patient is admitted to the hospital in order to reduce hospital mortality.
Efficacy of 4-(2-(4-nitrophenyl)-2-oxoethyl)-1-(thietane-3-yl)-1h-1,2,4-triazol-4 bromide in the rat model of inferior vena cava thrombosis
Authors: Wang Yi , Bulatova N. R. , Klen E. E. , Rozit G. A. , Nikitina I. L. , Startseva L. V. , Bogdanova Yu. A. , Shchekin V. S. , Samorodov A. V. 
Published: April 2024

Introduction. According to WHO, acute disorders of cerebral circulation are anticipated to become a predominant contributor to the global disease burden by 2030. The comprehensive management of vascular depression entails not only the use of antidepressants but also fundamental interventions. The development of a novel molecule based on thietane-containing heterocycles, merging the attributes of an antidepressant and an antiplatelet agent, holds promise for enhancing therapeutic efficacy in patients with acute cerebrovascular accidents through multimodal action. Objective is to conduct a preclinical assessment of 4-(2-(4-nitrophenyl)-2-oxoethyl)-1-(thietane-3-yl)-1H-1,2,4-triazole-4-th bromide concerning model thrombosis in rats. Materials and Methods. The investigation involved the evaluation of thrombosis processes and the haemostasis system in rats subjected to complete occlusion of the inferior vena cava within 24 hours post-thrombosis induction. Techniques employed included thromboelastography, Born aggregometry, standard clotting assays to appraise the coagulation facet of haemostasis, and morphological examinations. Results. The results demonstrate that 4-(2-(4-nitrophenyl)-2-oxoethyl)-1-(thietane-3-yl)-1H-1,2,4-triazole-4-th bromide mitigates thrombosis mass, restores platelet hyper aggregation, and counters hypercoagulation observed in acute inferior vena cava thrombosis in rats. Comparative analysis with reference drugs substantiates the superior effectiveness of the chosen compound in thrombosis prevention. Conclusion. The preclinical investigation of 4-(2-(4-nitrophenyl)-2-oxoethyl)-1-(thietane-3-yl)-1H-1,2,4-triazole-4-th bromide unveils a fusion of established antidepressant and antithrombotic activities, laying groundwork for further drug development endeavours.
Integral neuro-oncological diagnosis As the basis for personalized treatment Of brain tumors (on the example of gliomas In children)
Authors: Nazaralieva E. T. , Zabrodskaya Yu. M. , Gerasimov A. P. , Shevtsov M. A. , Nazaralieva E. T. , Kim A. V. , Djanaliev B. R. , Samochernykh K. A. 
Published: April 2024

Brain tumors are the most common group of neoplasms in children, which is in the top-3 causes of infant mortality from oncopathology. The aim of the study is to make a literature review of modern approaches to the personalization of treatment of CNS tumors in children based on the study of molecular genetics, immunohistochemical and imagingт characteristics. The article provides a description of the most common types of neoplasms of the nervous system — low grade gliomas (LGG), high grade gliomas (HGG), mixed glioneural tumors, etc. The molecular genetics, immunohistochemical, visualization characteristics of each type of gliomas are described. Modern information on prognosis and treatment of tumors is also given in the publication. The prognosis of the course of LGG/GNT in children depends more often on the patient’s age, histology, and location of the tumor, as well as its molecular profile. Older patients have a more favorable prognosis than younger children. Well-visualized tumors located superficially have a better outcome than diffuse gliomas, as well as deeply located tumors. Detection of BRAF mutations and FGFR rearrangements may indicate a better prognosis than in the presence of SNV. Local mutations of BRAF with concomitant deletion of CDKN2A, as well as mutations with H3.3 pK27 are the most dangerous.
Effects of Whole-body Electromyostimulation on knee pain and physical function in adults with symptomatic knee osteoarthritis: a randomized controlled trial
Authors: Kast Stephanie , Kemmler Wolfgang , Römer Frank W. , Kohl Matthias , Culvenor Adam G. , Mobasheri Ali , Uder Michael , von Stengel Simon 
Published: April 2024

Abstract

In a randomized, controlled study, whole-body electromyostimulation (WB-EMS) was investigated as a promising alternative to conventional strength training for the treatment of knee osteoarthritis (OA). 72 overweight participants with symptomatic knee OA were randomly assigned to WB-EMS (n = 36) or a usual care control group (CG, n = 36). For seven months, the WB-EMS group received three times per fortnight a WB-EMS training, while the CG was prescribed 6x physiotherapeutic treatments. The primary outcome, change in the pain subscale of the Knee injury and Osteoarthritis Outcome Score (KOOS), significantly improved in favour of the WB-EMS group, with a mean increase of 16.7 points versus 7.0 points in the CG (absolute difference between groups 9.0 points, 95%CI 2.9 to 15.1, p = 0.004). Secondary outcomes, including the other KOOS subscales (symptoms, function in daily living, function in sports/recreational activities and quality of life), 7-day pain diary, isometric muscle strength and lower limb function (30s sit-to-stand test), were also in favour of WB-EMS. With few dropouts and no reported adverse events, WB-EMS had a participation rate of 88% ± 10%. Overall, WB-EMS was found to be effective in relieving knee pain symptoms and improving physical function in individuals with symptomatic knee OA compared to usual care treatment.
MicroRNA-532-3p modulates colorectal cancer cell proliferation and invasion via suppression of FOXM1
Authors: Mahajan Ketakee , Pothuraju Ramesh , Das Ani , Nair Asha 
Published: April 2024

Abstract

Forkhead-box M1 (FOXM1) is a proliferation-associated transcription factor, overexpressed in almost all the cancers. Naturally, the mechanisms of FOXM1 regulation have been under investigation. Previously, we showed that FOXM1 binds to promoters of certain microRNAs. Database mining led to several microRNAs that might interact with FOXM1 3’UTR. The interactions between shortlisted microRNAs and FOXM1 3’UTR was quantitated by dual luciferase reporter assay. MicroRNA-532-3p interacted with 3’UTR of FOXM1 mRNA transcript most efficiently. MicroRNA-532-3p was ectopically overexpressed in colorectal cancer cell lines, leading to reduced transcript and protein levels of FOXM1 and cyclin B1, a direct transcriptional target of FOXM1. Flow cytometry analysis revealed an unaltered cell cycle. A clonogenic assay was conducted that revealed a decline in the ability of cells to form colonies. Additionally, wound healing assay and matrigel invasion assays were carried out. Significant reduction in migratory and invading cell numbers were observed, which were reinforced at molecular levels by the altered transcript and protein levels of the conventional EMT markers E-cadherin and vimentin. Overall, this study identifies the interaction between microRNA-532-3p and FOXM1 3’UTR, leading to reduced protein levels. Ectopic expression of miR-532-3p leads to suppression in cellular proliferation, migration and invasion in CRC cells.
Predicting Water Pipe Failures with Graph Neural Networks: Integrating Coupled Road and Pipeline Features
Authors: Hu Qunfang , Zhang Yu , Liu Wen , He Lei , Che Delu , Su Zhan 
Published: April 2024

Abstract

The reliability of urban water distribution networks (WDNs) is critical for public health and safety. This study presents a novel approach to predicting WDN failures by leveraging Graph Neural Networks (GNNs) and incorporating coupled features of road and water networks, with an emphasis on traffic-related characteristics. Our framework employs Graph Convolutional Networks (GCN), Graph Attention Networks (GAT), and GraphSAGE to capture the complex spatial dependencies and interactions between road infrastructure and water pipelines. We evaluate the performance of these models using a dataset from a Chinese city, focusing on metrics such as Area Under the Curve (AUC), accuracy, and recall. Our results indicate that GraphSAGE outperforms other models, demonstrating its effectiveness in leveraging neighborhood information for failure prediction. The analysis of feature importance highlights the significance of traffic-related attributes, such as the distance of pipelines from the center of intersections, road grades, and the angle of pipelines relative to roads, in addition to traditional factors like pipeline length, diameter, and age. By integrating these coupled features, our study offers a more accurate and comprehensive understanding of failure risks, providing valuable insights for proactive maintenance and management of urban WDNs.
Estrogen-dependent TRX2 activation reverts oxidative stress and metabolic dysfunction associated to steatotic disease
Authors: Morandi Andrea , Smiriglia Alfredo , Lorito Nicla , Bacci Marina , Subbiani Angela , Bonechi Francesca , Comito Giuseppina , Kowalik Marta Anna , Perra Andrea 
Published: April 2024

Abstract

Metabolic disfunction-associated steatotic liver disease (MASLD) encompasses a plethora of hepatic disorders ranging from steatosis to steatohepatitis with the worst clinical outcome represented by cirrhosis, liver failure, and hepatocellular carcinoma. According to the lower MASLD prevalence reported in pre-menopausal women compared to men, we identified a potential protective role of estrogens in counteracting the oxidative stress during disease induction and progression. We have used preclinical relevant in vitro models [i.e., immortalized cells and hepatocyte-like cells (HLC) derived from human embryonic stem cells (hESC)], exposed to sodium lactate, sodium pyruvate, and octanoic acid (LPO) to induce hepatic steatosis. This established practice of MASLD induction resulted in lipid droplet (LD) accumulation and increased mitochondrial and cytosolic reactive oxygen species (ROS) levels, paralleled by the reduction of several markers of hepatocyte function and differentiation. Here we found that estrogen replacement reduced ROS levels and LD content through the upregulation of mitochondrial thioredoxin 2 (TRX2), an antioxidant system that is under the control of the estrogen receptor alpha (hereafter referred as ER). Last, disrupting the TRX2 system using auranofin was sufficient to revert the scavenging effects exerted by estrogens, thus identifying a potential mechanism that could prevent or delay the progression of the disease.
In Vitro Study of Phycocyanin Effect on Cellular Defence Mechanisms and IL-17 Gene Expression in Stimulated Human Peripheral Blood Mononuclear Cells
Authors: Esmaeili Fatemeh , Esmaeili Behnaz , Emamshoushtari Mir Mehrshad , Helchi Salar , Pourmand Mahmoodreza , pajoumshariati Farshid 
Published: April 2024

Abstract

Chronic inflammatory diseases are typically characterized by persistent immune responses triggered by genetic factors and the release of inflammatory markers. While current pharmacological treatments, such as steroids and non-steroidal anti-inflammatory drugs, may be effective, they have limitations and can cause side effects. This study examines the effects of phycocyanin, an antioxidant pigment extracted from Spirulina platensis, in both encapsulated (ENPC) and non-encapsulated (PC) forms on the antioxidant activity of catalase, superoxide dismutase 1 (SOD1), and superoxide dismutase 2 (SOD2), along with the expression of the interleukin-17 (IL-17) inflammatory gene in peripheral blood mononuclear cells (PBMCs) under phytohemagglutinin (PHA)-induced inflammatory conditions. The MTT assay demonstrated that phycocyanin is not toxic to PBMCs, as cell viability exceeded 96% after 48 hours. The results indicated that ENPC and PC increased the enzyme expressions of catalase, SOD, but decreased the expression of IL-17 gene. Multi-groups analysis of genes expression using Kruskal-Wallis test revealed that no significant differences in catalase, SOD1, SOD2 and IL-17 gene expressions among PBMCs treated with different concentrations of C-PC (200 and 1000 µg.mL− 1) and in ENPC and PC forms. However, Mann-Whitney non-parametric test for pairwise gene expression analysis, revealing significant differences. Catalase expression showed noteworthy distinctions between unstimulated and PHA-stimulated cells in the presence of PC at 200 µg.mL− 1 and 1000 µg.mL− 1. Additionally, a significant contrast in SOD1 gene expression emerged between unstimulated and PHA-stimulated cells at PC 200 µg.mL− 1 Moreover, PHA-stimulated cells with ENPC at 1000 µg.mL− 1 exhibited a substantial decrease in IL-17 gene expression.
Research on calibration technique of camera coordinate system for binocular stereo vision system base on least-square method
Authors: li shengqian , zhang xiaofan 
Published: April 2024

Abstract

Index of the application for a binocular visual system. According to the measurement results of a binocular vision system is mainly used relative measuring accuracy to verify, but that can't be achieved to verify by artificial specific measurement, and also this work is measured in camera coordinate system, because of the camera's optical center couldn't be located, for the problem that where is the specific camera coordinate system, that can't give a specific location, but only giving the definition of a concept. In order to solve these problems, a calibration transformation method of the camera coordinate system based on the least square method is proposed, this method mainly through calibration of the camera coordinate system transforms to a presetting specific existence and positioning coordinate system. Meanwhile, by making the optical axis through the geometric center of a camera lens, then the accuracy of the binocular vision measurement system can be verified in the coordinate system. Finally, the result of the experiment shows that the proposed method is correct and effective to calibrate camera coordinate system, the accuracy of calibration is more higher, and the requiring equipment for verification is very simple.
Prognostic Risk Factor for Early Outcomes of Patients with Myelomeningocele: A Prospective Study
Authors: Alavi Seyed Ahmad Naseri , Rezkhah Amir , Majdi Alireza , Habibi Mohammad Amin , Bagheri Mohammad Mehdi , Jafarzadeh Fateme , Kobets Andrew J. 
Published: April 2024

Abstract

Introduction:
Myelomeningocele (MMC) is a prevalent form of neural tube defect. Despite advancements in treatment, MMC still poses significant health risks, including complications leading to chronic disability and mortality. Identifying prognostic risk factors for early outcomes is crucial for tailored intervention strategies.
Methods
This prospective study involved newborns and infants diagnosed with MMC who underwent surgery between 2020 and 2023 at Urmia University of Medical Sciences. Demographic data and surgical outcomes were collected, and participants were followed up for six months. Statistical analyses were conducted using descriptive statistics, Chi-Square, and independent t-test.
Results
The study included 29 MMC cases, with an incidence rate of 1.4 per 10,000 live births. Lesions were predominantly located in the lumbar spine. Although mortality rates appeared to increase with ascending lesion sites, this trend was not statistically significant. Short-term outcomes revealed high morbidity and mortality rates, with neurological deficits being the most prevalent complication. Multivariable analysis identified head circumference as a significant predictor of adverse outcomes (IRR = 1.37, 95% CI = 1.02 to 1.86, p = 0.04). Furthermore, an increase in birth weight was associated with a reduction in the incidence of requiring a ventriculoperitoneal shunt (IRR = 0.99, 95% CI = 0.998 to 0.999, p = 0.02)
Conclusion
This prospective study highlights prognostic risk factors for early outcomes in MMC patients, emphasizing the need for personalized intervention strategies. By addressing modifiable risk factors and implementing targeted interventions, healthcare providers can strive to improve outcomes and enhance the quality of life for MMC patients.