bluuebunny/crossref_metadata_2025_split huggingface dataset:
GLOBALIZACIÓN, VIOLENCIA, REVOLUCIONES. NUEVE TESIS.
Authors: Gilly Adolfo 
Published: May 2024

En el artículo se plantea el tema -para muchos analistas olvidado o ya definitivamente superado- de la revolución en el contexto de la globalización. Se argumenta que la globalización capitalista, lejos de eliminar las contradicciones que dieron origen a la revolución como parte de la modernidad capitalista, ha preparado un nuevo terreno para el estallido de movimientos sociales radicales. En la globalización se está conformando una nueva relación entre dominación, resistencia y violencia.
PRESBICH Y FURTADO: EL ESTRUCTURALISMO LATINOAMERICANO, DE JORGE LORA Y CARLOS MALLOQRUÍN
Authors: Hodara Joseph 
Published: May 2024

Tres motivos convergen para explicar el renovado interés en los fundadores del estructuralismo latinoamericano vinculado -hay que precisar- al desarrollo económico y social. El primero es una más amplia perspectiva que nos aleja de los ajetreos menores de la década de los cincuenta y sesenta y nos facilita, por consiguiente, la distinción entre lo importante y lo olvidable, entre lo fortuito y lo persistente. El segundo alude al surgimiento de nuevos paradigmas, que simultáneamente procuran explicar y proponer rumbos a la política pública en materia de crecimiento y desarrollo en las contingencias regionales que toman cuerpo desde los años setenta.
TRABAJO Y MOVIMIENTOS SOCIALES EN ARGENTINA
Authors: Palomino Héctor 
Published: May 2024

Los nuevos movimientos sociales en Argentina proponen nuevas formas de trabajo que trascienden sus acciones de protesta y movilización, concebidas aquí como emergentes de una actividad más vasta de creación de lazos y organizaciones sociales. Los emprendimientos encarados por los trabajodes de ampresas recuperadas, organizaciones de desocupados y asambleas barriales se inscriben en lo que tiende a denominarse "economía social", un espacio público donde el trabajo no se intercambia sólo ni principalmente por remuneraciones monetarias. Pero, a diferencia de las formas que prevalecieran con anterioridad en este campo, las impulsadas hoy por los movimientos adquieren una dimensión política: en estas nuevas formas el trabajo es la política.
PENSAR LA SEXTA... SER DE IZQUIERDA... SER ANTICAPITALISTA...
Authors: Modonesi Massimo 
Published: May 2024

La gran virtud de la Sexta, en consonancia con el método zapatista, es la apertura: la apertura de un debate y la apertura de un proceso político. Si éstos serán históricos, es decir, trascendentes, dependerá de los hombres y las mujeres y sus circunstancias, de las voluntades y las estructuras. En la Sexta, textualmente, aparece la idea de una “alternativa de izquierda”, como sinónimo de “anticapitalista” y “antineoliberal”, como opción “por la justicia, la democracia y la libertad”. Alrededor de esta formulación amplia, que inicia un proceso de definición colectiva, centraré mi reflexión, tratando de contribuir al diálogo al que nos están invitando los zapatistas.
COMMONWEALTH Y AGRIETAR EL CAPITALISMO. UNA LECTURA MUTUA
Authors: Hardt Michael , Holloway John 
Published: May 2024

Querido John:
Una de las cosas que me gusta de Agrietar el capitalismo, y que creo que comparte con Cambiar el mundo sin tomar el poder , es que traza la genealogía de la revuelta. En otras palabras, comienzas con la indignación, con la rabia, con la furia que las personas sienten, pero no te detienes allí. Tu argumento lleva la revuelta tanto hacia la práctica creativa como hacia la investigación teórica.
EL SUEÑO DE UNA COSA. EL EZLN PARA LA IZQUIERDA CONTEMPORÁNEA
Authors: Emmanuel Martín Lucio 
Published: May 2024

El presente trabajo es el resultado de una serie de reflexiones estimuladas por el seminario de posgrado Zapatismo y pensamiento crítico cursado en la Universidad Nacional del Sur durante octubre de 2015. El objetivo es realizar algunos comentarios que, en un registro personal basado en la experiencia militante de quien escribe, pongan el foco en aquellos elementos que consideramos que la emergencia y posterior desarrollo del movimiento zapatista de Chiapas, México, ha permitido repensar dentro de la tradición de izquierda que se propone la emancipación del hombre del dominio de otros hombres y “que lucha por trabajo, techo, alimentación, salud, educación, independencia, libertad, democracia, justicia y paz” (Primera Declaración de la Selva Lacandona 1994)
Effects of sacubitril/valsartan on the functional capacity of real-world patients in Italy: the REAL.IT study on heart failure with reduced ejection fraction
Authors: Sarullo Filippo Maria , Nugara Cinzia , Sarullo Silvia , Iacoviello Massimo , Di Gesaro Gabriele , Miani Daniela , Driussi Mauro , Correale Michele , Bilato Claudio , Passantino Andrea , Carluccio Erberto , Villani Alessandra , Degli Esposti Luca , D’Agostino Chiara , Peruzzi Elena , Poli Simone , Di Lenarda Andrea 
Published: May 2024

BackgroundHeart failure (HF) significantly affects the morbidity, mortality, and quality of life of patients. New therapeutic strategies aim to improve the functional capacity and quality of life of patients while controlling HF-related risks. Real-world data on both the functional and cardiopulmonary exercise capacities of patients with HF with reduced ejection fraction upon sacubitril/valsartan use are lacking.MethodsA multicenter, retrospective, cohort study, called REAL.IT, was performed based on the data collected from the electronic medical records of nine specialized HF centers in Italy. Cardiopulmonary exercise testing was performed at baseline and after 12 months of sacubitril/valsartan therapy, monitoring carbon dioxide production (VCO2) and oxygen consumption (VO2).ResultsThe functional capacities of 170 patients were evaluated. The most common comorbidities were hypertension and diabetes (i.e., 53.5 and 32.4%, respectively). At follow-up, both the VO2 peak (from 15.1 ± 3.7 ml/kg/min at baseline to 17.6 ± 4.7 ml/kg/min at follow-up, p &lt; 0.0001) and the predicted % VO2 peak (from 55.5 ± 14.1 to 65.5 ± 16.9, p &lt; 0.0001) significantly increased from baseline. The VO2 at the anaerobic threshold (AT-VO2) increased from 11.5 ± 2.6 to 12.5 ± 3.3 ml/kg/min (p = 0.021), and the rate ratio between the oxygen uptake and the change in work (ΔVO2/Δwork slope) improved from 9.1 ± 1.5 to 9.9 ± 1.6 ml/min/W (p &lt; 0.0001).ConclusionsSacubitril/valsartan improves the cardiopulmonary capacity of patients with HFrEF in daily clinical practice in Italy.
The L-shape relationship between hemoglobin, albumin, lymphocyte, platelet score and the risk of diabetic retinopathy in the US population
Authors: Ding Ranran , Zeng Yusong , Wei Zhimei , He Zitong , Jiang Zhixin , Yu Jinguo , You Caiyun 
Published: May 2024

BackgroundThe primary aim of this study was to investigate the correlation between diabetic retinopathy (DR) and the HALP score (hemoglobin, albumin, lymphocyte, and platelet) in individuals with diabetes within the United States population.MethodsThis cross-sectional investigation was based on the National Health and Nutrition Examination Survey (NHANES) database from 2003-2018. The following module calculated the HALP score: HALP score = [lymphocytes (/L) × hemoglobin (g/L) × albumin (g/L)]/platelets (/L). By performing the receiver operating characteristic (ROC) analysis, the optimal cutoff value of HALP was ascertained. Restricted cubic splines (RCS), multivariable logistic regression analysis, sensitivity analysis, and subgroup analysis were conducted to evaluate the effect of the HALP score on DR patients. Finally, the decision curve analysis (DCA) and clinical impact curve (CIC) were conducted to estimate the predictive power and clinical utility of the HALP score with clinical indicators.ResultsAccording to the cutoff value (42.9) determined by the ROC curve, the participants were stratified into a lower HALP group (HALPlow) and a higher HALP group (HALPhigh). An L-shaped relationship between HALP score and DR risk was presented in the RCS model (P for nonlinearity &lt;0.001). The DR risk sharply decreased with the increase of HALP, and the decline reached a plateau when HALP was more than 42.9. After fully adjustment, the multivariate logistic regression analysis found that HALPlow was an independent risk factor for DR (OR = 1.363, 95% CI: 1.111-1.671, P &lt; 0.001). Besides, sensitivity analysis showed consistent results. Furthermore, the combination of HALP score and clinical indicators demonstrated predictive power and clinical utility, as shown by the ROC curve, DCA, and CIC.ConclusionThe HALP score has an L-shaped correlation with the risk of DR, and thus, the HALP score may contribute to the timely intervention of diabetes patients.
Causal association of circulating metabolites with diabetic retinopathy: a bidirectional Mendelian randomization analysis
Authors: Li Bo , Zhao Xu , Xie Wanrun , Hong Zhenzhen , Cao Ye , Ding Yan , Zhang Yi 
Published: May 2024

IntroductionThe retina is a highly metabolically active tissue, and there is a lack of clarity about the relationship between metabolites and diabetic retinopathy (DR). This study used two-sample bidirectional Mendelian randomization (MR) analyses to identify causal relationships between metabolites and DR.MethodsGenetic variants were selected from the open-access Genome-Wide Association Studies (GWAS) summary database as proxies for the 1400 most recently published metabolites. MR analysis was performed to examine associations between these metabolite traits and DR. Single nucleotide polymorphism (SNP) data that were significantly associated with exposure were screened through association analysis. Validated instrumental variables (IVs) were obtained by removing SNPs with linkage disequilibrium (LD) and F-statistic values below 10. MR analyses were performed using the inverse variance weighted (IVW) method as the primary approach. The robustness of the results was verified by sensitivity analyses, including assessments of heterogeneity, horizontal pleiotropy, and the leave-one-out method.ResultsIn the IVW approach and in the primary analysis of several sensitivity analyses, genetically determined glycolithocholate sulfate levels, androstenediol (3 beta, 17 beta) monosulfate (1) levels, 1-stearoyl-2-arachidonoyl-GPE (18:0/20:4) levels, 1-oleoyl-2-arachidonoyl-GPE (18:1/20:4) levels, 1-oleoyl-2-linoleoyl-GPE (18:1/18:2) levels, X-26109 levels, N6-methyllysine levels, (N6,N6-dimethyllysine levels), and (N2-acetyl,N6,N6-dimethyllysine levels) were negatively associated with the risk of DR. 5-hydroxymethyl-2-furoylcarnitine levels and the glutamate-to-alanine ratio were positively associated with the risk of DR. No reverse causal association was found between DR and metabolites.DiscussionThis MR study suggests that nine metabolites may have a protective effect in DR, while two metabolites may be associated with an increased risk of DR. However, further research is needed to confirm these findings. Supplementation with beneficial metabolites may reduce DR risk and could potentially be a novel therapeutic approach to DR treatment.
Integrated time-series biochemical, transcriptomic, and metabolomic analyses reveal key metabolites and signaling pathways in the liver of the Chinese soft-shelled turtle (Pelodiscus sinensis) against Aeromonas hydrophila infection
Authors: Ji Liqin , Chen Chen , Zhu Junxian , Hong Xiaoyou , Liu Xiaoli , Wei Chengqing , Zhu Xinping , Li Wei 
Published: May 2024

IntroductionAeromonas hydrophila, a bacterium widely distributed in the natural environment, causes multiple diseases in various animals. Exploring the mechanism of the host defense against A. hydrophila can help develop efficient strategies against Aeromonas infection.MethodsHerein, we investigated the temporal influence of A. hydrophila on the Chinese soft-shelled turtle, an economically important species, at the biochemical, transcriptomic, and metabolomic levels. Plasma parameters were detected with the test kits. Transcriptome and metabolome were respectively applied to screen the differentially expressed genes and metabolites.ResultsThe contents or activities of these plasma parameters were significantly increased at 24 hpi and declined at 96 hpi, indicating that 24 and 96 hpi were two important time points during infection. Totals of 3121 and 274 differentially expressed genes (DEGs) from the transcriptome while 74 and 91 differentially abundant metabolites (DAMs) from the metabolome were detected at 24 and 96 hpi. The top DEGs at 24 hpi included Ccl2, Ccl3, Ccl4, Il1β, Il6, Il7, Il15, Tnf, and Tnfr1 while Zap70, Cd3g, Cd8a, Itk, Pik3r3, Cd247, Malt1, and Cd4 were the most abundant at 96 hpi. The predominant DAMs included O-phospho-L-serine, γ-Aminobutyric acid, orotate, L-tyrosine, and L-tryptophan at 24 hpi, as well as L-glutamic acid, L-arginine, glutathione, glutathione disulfide, and citric acid at 96 hpi.DiscussionThe combined analysis of DEGs and DAMs revealed that tryptophan metabolism, nicotinate and nicotinamide metabolism, as well as starch and sucrose metabolism, were the most important signaling pathways at the early infective stage while tyrosine metabolism, pyrimidine metabolism, as well as alanine, aspartate and glutamate metabolism were the most crucial pathways at the later stage. In general, our results indicated that the Chinese soft-shelled turtle displays stage-specific physiological responses to resist A. hydrophila infection.
Plasma proteomics analysis of Chinese HIV-1 infected individuals focusing on the immune and inflammatory factors afford insight into the viral control mechanism
Authors: Ni Wanqi , Ren Li , Liao Lingjie , Li Dan , Luo Zhenwu , Zhu Meiling , Liu Ying , Xing Hui , Wang Zheng , Shao Yiming 
Published: May 2024

BackgroundLong-term non-progressors (LTNPs) with HIV infection can naturally control viral replication for up to a decade without antiretroviral therapy (ART), but the underlying mechanisms of this phenomenon remain elusive.MethodsTo investigate the relevant immune and inflammatory factors associated with this natural control mechanism, we collected plasma samples from 16 LTNPs, 14 untreated viral progressors (VPs), 17 successfully ART-treated patients (TPs), and 16 healthy controls (HCs). The OLINK immune response panel and inflammation panel were employed to detect critical proteins, and the plasma neutralizing activity against a global panel of pseudoviruses was assessed using TZM-bl cells.ResultsThe combination of IL17C, IL18, DDX58, and NF2 contributed to discriminating LTNPs and VPs. IL18 and CCL25 were positively associated with CD4+ T cell counts but negatively correlated with viral load. Furthermore, CXCL9 and CXCL10 emerged as potential supplementary diagnostic markers for assessing the efficacy of antiretroviral therapy (ART). Finally, TNFRSF9 displayed positive correlations with neutralization breadth and Geometry Median Titer (GMT) despite the lack of significant differences between LTNPs and VPs.ConclusionIn summary, this study identified a set of biomarkers in HIV-infected individuals at different disease stages. These markers constitute a potential network for immune balance regulation in HIV infection, which is related to the long-term control of HIV by LTNPs. It provides important clues for further exploring the immune regulatory mechanism of HIV.
Follicular lymphoma regulatory T-cell origin and function
Authors: Rodriguez Stéphane , Alizadeh Mehdi , Lamaison Claire , Saintamand Alexis , Monvoisin Céline , Jean Rachel , Deleurme Laurent , Martin-Subero Jose Ignacio , Pangault Céline , Cogné Michel , Amé-Thomas Patricia , Tarte Karin 
Published: May 2024

IntroductionFollicular Lymphoma (FL) results from the malignant transformation of germinal center (GC) B cells. FL B cells display recurrent and diverse genetic alterations, some of them favoring their direct interaction with their cell microenvironment, including follicular helper T cells (Tfh). Although FL-Tfh key role is well-documented, the impact of their regulatory counterpart, the follicular regulatory T cell (Tfr) compartment, is still sparse.MethodsThe aim of this study was to characterize FL-Tfr phenotype by cytometry, gene expression profile, FL-Tfr origin by transcriptomic analysis, and functionality by in vitro assays.ResultsCD4+CXCR5+CD25hiICOS+ FL-Tfr displayed a regulatory program that is close to classical regulatory T cell (Treg) program, at the transcriptomic and methylome levels. Accordingly, Tfr imprinting stigmata were found on FL-Tfh and FL-B cells, compared to their physiological counterparts. In addition, FL-Tfr co-culture with autologous FL-Tfh or cytotoxic FL-CD8+ T cells inhibited their proliferation in vitro. Finally, although FL-Tfr shared many characteristics with Treg, TCR sequencing analyses demonstrated that part of them derived from precursors shared with FL-Tfh. DiscussionAltogether, these findings uncover the role and origin of a Tfr subset in FL niche and may be useful for lymphomagenesis knowledge and therapeutic management.
A novel humanized mouse model for HIV and tuberculosis co-infection studies
Authors: Bohórquez José Alejandro , Adduri Sitaramaraju , Ansari Danish , John Sahana , Florence Jon , Adejare Omoyeni , Singh Gaurav , Konduru Nagarjun V. , Jagannath Chinnaswamy , Yi Guohua 
Published: May 2024

BackgroundTuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), continues to be a major public health problem worldwide. The human immunodeficiency virus (HIV) is another equally important life-threatening pathogen. HIV infection decreases CD4+ T cell levels markedly increasing Mtb co-infections. An appropriate animal model for HIV/Mtb co-infection that can recapitulate the diversity of the immune response in humans during co-infection would facilitate basic and translational research in HIV/Mtb infections. Herein, we describe a novel humanized mouse model.MethodsThe irradiated NSG-SGM3 mice were transplanted with human CD34+ hematopoietic stem cells, and the humanization was monitored by staining various immune cell markers for flow cytometry. They were challenged with HIV and/or Mtb, and the CD4+ T cell depletion and HIV viral load were monitored over time. Before necropsy, the live mice were subjected to pulmonary function test and CT scan, and after sacrifice, the lung and spleen homogenates were used to determine Mtb load (CFU) and cytokine/chemokine levels by multiplex assay, and lung sections were analyzed for histopathology. The mouse sera were subjected to metabolomics analysis.ResultsOur humanized NSG-SGM3 mice were able to engraft human CD34+ stem cells, which then differentiated into a full-lineage of human immune cell subsets. After co-infection with HIV and Mtb, these mice showed decrease in CD4+ T cell counts overtime and elevated HIV load in the sera, similar to the infection pattern of humans. Additionally, Mtb caused infections in both lungs and spleen, and induced granulomatous lesions in the lungs. Distinct metabolomic profiles were also observed in the tissues from different mouse groups after co-infections.ConclusionThe humanized NSG-SGM3 mice are able to recapitulate the pathogenic effects of HIV and Mtb infections and co-infection at the pathological, immunological and metabolism levels and are therefore a reproducible small animal model for studying HIV/Mtb co-infection.
Efficacy and safety of lenvatinib plus durvalumab combined with hepatic arterial infusion chemotherapy for unresectable intrahepatic cholangiocarcinoma
Authors: Zhao Rongce , Zhou Jing , Miao Zhaoxia , Xiong Xinhao , Wei Wei , Li Shaohua , Guo Rongping 
Published: May 2024

BackgroundThe prognosis for unresectable intrahepatic cholangiocarcinoma (ICC) is poor and the efficacy of traditional chemotherapy remains unsatisfactory. Hepatic arterial infusion chemotherapy (HAIC) with oxaliplatin, leucovorin, and 5-fluorouracil (FOLFOX) is effective in patients with unresectable ICC. In this study, we determined the preliminary clinical efficacy and safety of lenvatinib plus durvalumab combined with FOLFOX-HAIC in patients with untreated, unresectable ICC.Materials and methodsBetween July 2021 and July 2023, patients with unresectable ICC who initially received lenvatinib plus durvalumab combined with FOLFOX-HAIC at the Sun Yat-Sen University Cancer Center (SYSUCC) were reviewed for eligibility. Efficacy was evaluated by tumor response rate and survival, and safety was assessed by the frequency of key adverse events (AEs).ResultsA total of 28 eligible patients were enrolled. The objective response rates (ORRs) based on mRECIST and RECIST 1.1 criteria were 65.2% and 39.1%, respectively. The median OS was 17.9 months (95% CI, 5.7–30.1) and the median PFS was 11.9 months (95% CI, 6.7–17.1). Most patients (92.9%) experienced adverse events (AEs), whereas 46.5% (13/28) experienced grade 3 or 4 AEs.ConclusionLenvatinib plus durvalumab combined with FOLFOX-HAIC showed promising antitumor activity and manageable AEs in patients with treatment-naive unresectable ICC. This regimen may be suitable as a novel first-line treatment option for this patient population.
Intervention of computer-assisted cognitive training combined with occupational therapy in people with mild cognitive impairment: a randomized controlled trial
Authors: Wen Xin , Song Shangrong , Tian Hui , Cui Hang , Zhang Lijuan , Sun Yajie , Li Mingyue , Wang Yonghong 
Published: May 2024

ObjectiveInvestigate the impact of combined computerized cognitive training and occupational therapy on individuals with mild cognitive impairment (MCI).MethodsWe randomly assigned 118 MCI patients into two groups: a combined intervention group (n = 37) and a control group (n = 81), the latter receiving standard nursing care. The intervention group additionally underwent 12 weeks of computerized cognitive training and occupational therapy. Blind assessors evaluated cognitive performance, anxiety, depression, and daily living activities before the intervention, post-intervention, and at a 3-month follow-up.ResultsRepeated-measures analysis of variance showed that the sMoCA scores, HAMA scores, and ADL scores of the experimental group at T2 (post-intervention) and T3 (3-month follow-up) were higher than those of the control group, and the difference was statistically significant (p &lt; 0.001, p &lt; 0.001, p = 0.026).ConclusionComputerized cognitive training combined with occupational therapy can improve patients’ cognitive status, enhance their compliance with continuing care, and maintain their anxiety and self-care ability at a stable level.Clinical trial registrationhttps://www.chictr.org.cn/index.html, identifier ChiCTR2200065014.