bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pulmonary Infundibular Stenosis Secondary to a Mediastinal Hodgkin Lymphoma Tumor Invasion in a Young Adult Male: What a Rare Occurrence!
Authors: Mulendele P.M , Rezzouk I. , Njie M. , Bettar M.S , Timimi AL , Assklou A. , Bouziane M. , Haboub M. , Arous S. , Habbal R. 
Published: April 2024

Introduction: Cardiac involvement is a rare unusual localization of Hodgkin lymphoma, as it’s known that primary lymphomas of the heart are rare. They develop primarily in the right atrium, and extend to the pericardium in about one third of the cases. Pulmonary infundibular stenosis secondary to mediastinal mass Hodgkin lymphoma invasion is rare but not impossible especially in relapse cases.
Case Report: A rare case of a young adult patient diagnosed with Hodgkin Lymphoma under chemotherapy presents a relapse of his pathology associated with heart failure; predominantly, right heart failure due to extension of the mediastinal mass tumor to the right cavities of the heart causing pulmonary infundibular stenosis which is a rare occurrence. He was put under an intense chemotherapy and symptomatic heart failure treatment with close follow-up after multi-disciplinary discussions including cardiologist, onco-hematologists and cardiothoracic surgeons. Three months later, a significant reduction of the mass was observered.
Conclusion : Pulmonary infundibular stenosis secondary to mediastinal Hodgkin lymphoma invasion is a rare entity of secondary tumors of the heart. Multimodal imagery is the key tool for diagnosis. There prognosis depend on multiple factors but generally good in younger adult patients compared to aged individuals.
Diagnosis of Crude Oil Impacted Soil in Eleme Local Government Area, Rivers State, Nigeria
Authors: SJ Olukaejire , CC Ifiora , PA Osaro , LC Osuji , AI Hart 
Published: April 2024

This study assessed the potential effects of crude oil on soil quality in Eleme Local Government Area of Rivers State. Soil samples were collected from 10 geopolitical wards of the Eleme Local Government Area of Rivers State, Nigeria. The soil and water samples were subjected to physicochemical and microbial analyses to test for pH, heavy metal content (Cadmium, Iron, Lead, Copper, and Chromium), Total Petroleum Hydrocarbon (TPH), Benzene, Toluene, Ethylbenzene and Xylene (BTEX) contents and Total Viable Count (TVC). Parameters of the soil were determined and compared to the control site and the permissible World Health Organization (WHO) limits. The soil pH varied across location, ranging from 5.5-7. TPH varied in across the different communities studied, ranging from 1.275-4889.29 mg/kg, and exceeding the WHO limit of 10mg/kg in all polluted soils. The result for the heavy metals showed that the soil samples of the studied sites showed increases in all heavy metals, when compared to the control. Cd values ranged from 0.01 - 0.32 mg/kg; Fe from 1325.23 - 9364.76 mg/kg, Pb from 0.001 mg/kg to 0.93 mg/kg and Cr from 0.001 - 5.08 mg/kg, all with WHO limits. The result for the microbial showed increases in TVC content in polluted soil. Results indicate that crude oil spillage has led to significant contamination of soil in the study area which could affect soil fertility.
Enantioselective Benzylic Hydroxylation with Pseudomonas monteilii TA‐5: A Simple Method for the Syntheses of (R)‐Benzylic Alcohols Containing Reactive Functional Groups
Authors: Chen Yongzheng , Lie Felicia , Li Zhi 
Published: September 2009

AbstractHighly enantioselective benzylic hydroxylations of benzene derivatives (1–4) containing reactive functional groups were achieved for the first time with Pseudomonas monteilii TA‐5 as biocatalyst, giving the corresponding (R)‐benzylic alcohols 5–8 in 93–99% ee as the only products. Preparative biotransformations were demonstrated by the biohydroxylation of 1 and 2 with resting cells of P. monteilii TA‐5 to afford (R)‐5 in 94% ee and 66% yield and (R)‐6 in 94% ee and 56% yield, respectively. The highly enantioselective biohydroxylations represent a simple access to (R)‐benzylic alcohols containing reactive functional groups that are useful pharmaceutical intermediates and versatile chiral building blocks.
Salvage therapy for acute myeloid leukemia with fludarabine, cytarabine, and idarubicin with or without gemtuzumab ozogamicin and with concurrent or sequential G‐CSF
Authors: Martin Mike G. , Augustin Kristan M. , Uy Geoffrey L. , Welch John S. , Hladnik Lindsay , Goyal Sagun , Tiwari Divya , Monahan Ryan S. , Reichley Richard M. , Cashen Amanda F. , Stockerl‐Goldstein Keith , Westervelt Peter , Abboud Camille N. , DiPersio John F. , Vij Ravi 
Published: September 2009

AbstractThe current salvage therapies for relapsed/refractory acute myeloid leukemia (AML) are unsatisfactory. Over the past 7 years, we have used two salvage regimens: fludarabine, cytarabine, and idarubicin with (FLAG‐IM) or without gemtuzumab ozogamicin (GO) (9 mg/m2 on Day 8) (FLAG‐I) in relapsed/refractory AML. Three‐quarters of patients also received concurrent G‐CSF. Seventy‐one patients were treated, 23 with FLAG‐I and 48 with FLAG‐IM. The median duration of follow‐up was 30.6 months. The treatment groups were well balanced with median ages of 48 years (range 18–70) and 47 years (range 20–68), unfavorable cytogenetics in 57% and 35%, prior allogeneic stem cell transplant in 43% and 42%, and CR1 duration <1 year in 60% and 67%, respectively, for FLAG‐I and FLAG‐IM. The complete remission (CR) rate in the FLAG‐I group was 39% with an additional 13% achieving a CRp [overall response rate (ORR) 52%]; the CR rate in the FLAG‐IM group was 29% with an additional 27% achieving a CRp (ORR 56%). The median duration of response (DOR; 16.8 vs. 8.3 months), event‐free survival (EFS; 7.4 vs. 4.1 months), and overall survival (OS; 8.8 vs. 5.0 months) trended to favor FLAG‐I over FLAG‐IM. The patients who received G‐CSF concurrent with chemotherapy had superior overall response rate (ORR; 62% vs. 29%, P = 0.026), median EFS (6.2 vs. 3.4 months, P = 0.010), and OS (8.8 vs. 3.9 months, P = 0.004) when compared with those who sequentially received G‐CSF and chemotherapy, regardless of chemotherapy regimen. The addition of GO, at this dose and schedule, to FLAG‐I failed to improve the outcomes in patients with relapsed/refractory AML. The patients who received G‐CSF concurrently with chemotherapy had improved outcomes. Am. J. Hematol., 2009. © 2009 Wiley‐Liss, Inc.
Molecular and Supramolecular Networks on Surfaces: From Two‐Dimensional Crystal Engineering to Reactivity
Authors: Elemans Johannes A. A. W. , Lei Shengbin , De Feyter Steven 
Published: September 2009

AbstractThe invention of the scanning tunneling microscope has led to the visualization of molecules in real space on atomically flat conductive substrates. This has boosted research into supramolecular chemistry on surfaces. In this Review, we highlight recent developments in the design and functionality of supramolecular surface patterns, with special attention paid to those networks which are chiral or contain a high degree of porosity as well as to the reactivity, which is one of the most important recent developments in supramolecular surface chemistry.
Influence of the Weißenberg number on the stability of Oldroyd kind fluids
Authors: Scurtu N. , Bänsch E. 
Published: September 2009

AbstractThis paper is concerned with nonlinear rheological fluids of Oldroyd type. We present a (formal) stability analysis of the corresponding system of equations, showing stability limits on the Weißenberg number in certain cases. To this end, we proceed in several steps, thus separating the possible sources for instabilities. First, a spectral analysis of the linearized Oldroyd system is presented. Then, the influence of the βa‐term on the stability of the constitutive stress equation and of the full Oldroyd system is examined. Moreover, because this stability analysis is of formal and linear nature, we complement it by numerical simulations for the system showing that the upper limit of the Weißenberg number found by the stability analysis is fairly sharp. We thereby try to shed some light on the high Weißenberg number problem, that is, the problem why in certain cases there seem to exist no solutions to the Oldroyd problem for large Weißenberg numbers. Copyright © 2009 Curtin University of Technology and John Wiley & Sons, Ltd.
Phytoecdysteroid C2‐hydroxylase is microsomal in spinach, Spinacia oleracea L.
Authors: Bakrim Ahmed , Guittard Emilie , Maria Annick , De Virville Jacques Davy , Lafont René , Takvorian Najat 
Published: September 2009

AbstractAn enzyme involved in the biosynthesis of phytoecdysteroids, the C2‐hydroxylase, has been investigated in spinach, Spinacia oleracea. This enzyme is microsomal and its Km has been determined using 2‐deoxy‐20‐hydroxyecdysone as substrate (Km=3.72 µM). It is much more efficient with 2‐deoxy‐20‐hydroxyecdysone than with 2‐deoxyecdysone and, conversely, the C20‐hydroxylase is more active on 2‐deoxyecdysone than on ecdysone. These data support the conclusion that C20‐hydroxylation precedes C2‐hydroxylation. The C2‐hydroxylase is inhibited by high concentrations of 20E. Substrate specificity and subcellular localization of C2‐hydroxylase differ between plants and insects, and these data, as well as those previously reported on other biosynthetic steps, show the great difference between plant and insect ecdysteroid biosynthetic pathways and suggest an independent origin for the pathways in both kingdoms. © 2009 Wiley Periodicals, Inc.
Characterization of alternatively spliced transcripts encoding heat shock transcription factor in cultured cells of the cabbage armyworm, Mamestra brassicae
Authors: Sonoda Shoji , Tsumuki Hisaaki 
Published: September 2009

AbstractA gene encoding heat shock transcription factor (HSF) was cloned and sequenced from cultured cells of the cabbage armyworm, Mamestra brassicae. The cDNA potentially encoded a 699‐aa protein, with a calculated molecular weight of 77.8 kDa. Deduced amino acid identities to HSFs from Aedes aegypti and Drosophila melanogaster were 36 and 34%, respectively. Analysis of the genomic DNA revealed eight exons and three optional exons: a, b, and c. Exon a contained a premature in‐frame stop codon that would generate a truncated protein. When the cells were exposed to high temperature or cadmium, no particular alternative transcripts showed significant up‐ or down‐regulated expression relative to the total amount of the transcripts. These results suggest that alternative splicing may not be a principal mechanism for regulation of M. brassicae HSF gene expression in response to heat shock and cadmium. © 2009 Wiley Periodicals, Inc.
Understanding African easterly waves: a moist singular vector approach
Authors: Cornforth Rosalind J. , Hoskins Brian J. 
Published: September 2009

AbstractMoist singular vectors (MSV) have been applied successfully to predicting mid‐latitude storms growing in association with latent heat of condensation. Tropical cyclone sensitivity has also been assessed. Extending this approach to more general tropical weather systems here, MSVs are evaluated for understanding and predicting African easterly waves, given the importance of moist processes in their development. First results, without initial moisture perturbations, suggest MSVs may be used advantageously. Perturbations bear similar structural and energy profiles to previous idealised non‐linear studies and observations. Strong sensitivities prevail in the metrics and trajectories chosen, and benefits of initial moisture perturbations should be appraised. Copyright © 2009 Royal Meteorological Society
The impact of climate change on daily precipitation statistics in Jordan and Israel
Authors: Black Emily 
Published: September 2009

AbstractA regional climate model is used to investigate changes in Israel and Jordan precipitation at the end of the 21st century on daily to monthly timescales. The model predicts that this region will get significantly drier at the peak of the rainy season, reflecting a reduction in both the frequency and duration of rainy events. These changes may be associated with a reduction in the strength of the Mediterranean storm track. Copyright © 2009 Royal Meteorological Society
Gestational high saturated fat diet alters C57BL/6 mouse perinatal skeletal formation
Authors: Liang Chengya , Oest Megan E. , Jones Jeryl C. , Prater M. Renee 
Published: September 2009

AbstractBACKGROUND:Our present work joins growing evidence that gestational environment (maternal nutrition, health, and chemical exposures) strongly influences prenatal development (www.thebarkertheory.org). The present study suggests that maternal consumption of a diet high in saturated fats (HFD), which approximates the macronutrient content of fast food, impairs perinatal skeletal development.METHODS:In this study, administration of HFD (32% saturated fat) for one month prior to conception and throughout gestation in C57BL/6J mice was associated with a marked reduction in late‐gestation fetal skeletal developmental delay that included shorter long bone lengths, decreased average bone mineral density (ABMD; 20%), lower total bone volume (TBV; 45%), and shorter crown‐to‐rump length (C‐R; 12%), as compared to controls.RESULTS:A putative mechanism linking prenatal HFD to dysregulated fetal osteogenesis is HFD‐induced oxidative stress (OS), which has been shown in our laboratory to cause placental labyrinthine vascular damage and impaired fetal signaling pathways associated with osteogenesis (Liang et al., unpublished data).CONCLUSIONS:The theory of HFD‐associated, OS‐mediated placental damage and skeletal pathogenesis was supported by demonstrating a protective effect of the dietary antioxidant quercetin (Q) against HFD‐associated fetal skeletal developmental delay. Improved understanding of the role of HFD and elevated OS in fetal skeletal development will help to more completely elucidate the importance of the prenatal environment to fetal formation, and will be applied to better understand the contribution of the fetal environment to long‐term risk of adult‐onset disease.Birth Defects Res (Part B)86:362–369, 2009. © 2009 Wiley‐Liss, Inc.
Intrauterine exposure to high saturated fat diet elevates risk of adult‐onset chronic diseases in C57BL/6 mice
Authors: Liang Chengya , Oest Megan E. , Prater M. Renee 
Published: September 2009

AbstractBACKGROUND: The developmental environment is thought to determine, in part, lifelong metabolic parameters and risk of adult disease. Effects of maternal malnutrition on fetal growth have been studied extensively, and the role of poor prenatal diet in elevating lifelong risk of cardiovascular and metabolic disease has been well characterized (www.thebarkertheory.com). However, the contribution of gestational high saturated fat diet (HFD) to adult‐onset metabolic disease and skeletal dysfunction has only recently been recognized, and as such is incompletely understood. METHODS: The present study evaluates the pathophysiologic mechanisms linking gestational HFD (approximating the macronutrient content of fast food) and elevated oxidative stress (OS) to adult‐onset skeletal, cardiovascular, and metabolic dysfunction. RESULTS: Results of this study demonstrate that adult offspring of dams fed HFD during pregnancy exhibited adult hyperglycemia, insulin resistance, obesity, and hypertension, despite being fed healthy standard rodent chow throughout postnatal life. These offspring also showed significantly lower femoral epiphyseal average bone mineral density (ABMD) at 6 months of age, and dysregulation of distal femoral trabecular architecture at 12 months of age, characteristic of osteoporosis. Incidence of these adult‐onset adverse skeletal and metabolic effects was reduced by supplementing the pregnant dam with the antioxidant (quercetin, Q) during pregnancy. CONCLUSIONS: Collectively, these data suggest that offspring of dams who consume a diet rich in saturated fats during pregnancy are at increased risk of adult‐onset chronic disease. Additionally, these chronic diseases were determined to be in‐part OS‐mediated, and preventable by increasing a prenatal dietary antioxidant; this knowledge offers both a putative mechanism of disease pathogenesis and suggests a potential preventive strategy. Birth Defects Res (Part B) 86:377–384, 2009. © 2009 Wiley‐Liss, Inc.
Potent Fluoro‐oligosaccharide Probes of Adhesion in Toxoplasmosis
Authors: Allman Sarah A. , Jensen Henrik H. , Vijayakrishnan Balakumar , Garnett James A. , Leon Ester , Liu Yan , Anthony Daniel C. , Sibson Nicola R. , Feizi Ten , Matthews Stephen , Davis Benjamin G. 
Published: September 2009

AbstractUnnatural, NMR‐ and MRI‐active fluorinated sugar probes, designed and synthesised to bind to the pathogenic protein TgMIC1 from Toxoplasma gondii, were found to display binding potency equal to and above that of the natural ligand. Dissection of the binding mechanism and modes, including the first X‐ray crystal structures of a fluoro‐oligosaccharide bound to a lectin, demonstrate that it is possible to create effective fluorinated probe ligands for the study of, and perhaps intervention in, sugar–protein binding events.
CFD Simulation of Inlet Design Effect on Deoiling Hydrocyclone Separation Efficiency
Authors: Noroozi S. , Hashemabadi S. H. 
Published: September 2009

AbstractAn Eulerian‐Eulerian three‐dimensional CFD model was developed to study the effect of different inlet designs on deoiling hydrocyclone separation efficiency. Reynolds averaged Navier Stokes and continuity equations were applied to solve steady turbulent flow through the cyclone with the Reynolds stress model. In addition, the modified drag correlation for liquid‐liquid emulsion with respect to the Reynolds number range and viscosity ratio of two phases was used and the simulation results were compared with those predicted by the Schiller‐Naumann correlation. Pressure profile, tangential and axial velocities and separation efficiency of the deoiling hydrocyclone were calculated for four different inlet designs and compared with the standard design. The simulation results for the standard design demonstrate an acceptable agreement with reported experimental data. The results show that all new four inlet designs offer higher efficiencies compared to the standard design. The difference between the efficiency of the LLHC, of the new inlets and the standard design can be improved by increasing the inlet velocity. Furthermore, the simulations show that the separation efficiency can be improved by about 10 % when using a helical form of inlet.
The Role of One‐Electron Reduction of Lipid Hydroperoxides in Causing DNA Damage
Authors: Crean Conor , Shao Jie , Yun Byeong Hwa , Geacintov Nicholas E. , Shafirovich Vladimir 
Published: September 2009

AbstractThe in vivo metabolism of plasma lipids generates lipid hydroperoxides that, upon one‐electron reduction, give rise to a wide spectrum of genotoxic unsaturated aldehydes and epoxides. These metabolites react with cellular DNA to form a variety of pre‐mutagenic DNA lesions. The mechanisms of action of the radical precursors of these genotoxic electrophiles are poorly understood. In this work we investigated the nature of DNA products formed by a one‐electron reduction of (13S)‐hydroperoxy‐(9Z,11E)‐octadecadienoic acid (13S‐HPODE), a typical lipid molecule, and the reactions of the free radicals thus generated with neutral guanine radicals, G(−H).. A novel approach was devised to generate these intermediates in solution. The two‐photon‐induced ionization of 2‐aminopurine (2AP) within the 2′‐deoxyoligonucleotide 5′‐d(CC[2AP]TCGCTACC) by intense nanosecond 308 nm excimer laser pulses was employed to simultaneously generate hydrated electrons and radical cations 2AP.+. The latter radicals either in cationic or neutral forms, rapidly oxidize the nearby G base to form G(−H).. In deoxygenated buffer solutions (pH 7.5), the hydrated electrons rapidly reduce 13S‐HPODE and the highly unstable alkoxyl radicals formed undergo a prompt β‐scission to pentyl radicals that readily combine with G(−H).. Two novel guanine products in these oligonucleotides, 8‐pentyl‐ and N2‐pentylguanine, were identified. It is shown that the DNA secondary structure significantly affects the ratio of 8‐pentyl‐ and N2‐pentylguanine lesions that changes from 0.9:1 in single‐stranded, to 1:0.2 in double‐stranded oligonucleotides. The alkylation of guanine by alkyl radicals derived from lipid hydroperoxides might contribute to the genotoxic modification of cellular DNA under hypoxic conditions. Thus, further research is warranted on the detection of pentylguanine lesions and other alkylguanines in vivo.
1‐Phenyl‐1,2‐cyclohexadiene: Astoundingly High Enantioselectivities on Generation in a Doering–Moore–Skattebøl Reaction and Interception by Activated Olefins
Authors: Christl Manfred , Fischer Hartmut , Arnone Mario , Engels Bernd 
Published: September 2009

AbstractThe resolution of (1α,5α,6α)‐6‐bromo‐6‐fluoro‐1‐phenylbicyclo[3.1.0]hexane (rac‐5) provided the enantiomerically pure precursors (−)‐5 and (+)‐5 of 1‐phenyl‐1,2‐cyclohexadiene. On treatment of (−)‐5 with methyllithium in the presence of 2,5‐dimethylfuran, the pure (−)‐enantiomer of the [4+2] cycloadduct of 2,5‐dimethylfuran onto 1‐phenyl‐1,2‐cyclohexadiene was obtained exclusively. From this result, it is concluded that pure (M)‐1‐phenyl‐1,2‐cyclohexadiene ((M)‐7) emerged from (−)‐5 and was enantiospecifically intercepted to give the product. In the case of indene as trap for (M)‐7, the (−)‐ and the (+)‐enantiomer of the [2+2] cycloadduct were formed in the ratio of 95:5. Highly surprising, remarkable enantioselectivities were also observed, when (M)‐7 was trapped with styrene to furnish two diastereomeric [2+2] cycloadducts. Hence, the achiral conformation of the diradical conceivable as intermediate cannot play a decisive part. The enantioselective generation of (M)‐ and (P)‐7 by the β‐elimination route was tested as well. Accordingly, 1‐bromo‐2‐phenylcyclohexene was exposed to the potassium salt of (−)‐menthol in the presence of 2,5‐dimethylfuran, and the enantiomeric [4+2] cycloadducts of the latter onto (M)‐ and (P)‐7 were produced in the ratio of 55:45.
N‐Fusion Approach in Construction of Contracted Carbaporphyrinoids: Formation of N‐Fused Telluraporphyrin
Authors: Pacholska‐Dudziak Ewa , Ulatowski Filip , Ciunik Zbigniew , Latos‐Grażyński Lechosław 
Published: September 2009

AbstractInsertion of PCl3 into 5,10,15,20‐tetraaryl‐21‐telluraporphyrin leads to a phosphorus complex of N‐fused dihydrotelluraporphyrin with an inverted tellurophene ring. Its CNN coordination core places the macrocycle in the family of contracted carbaporphyrinoids. A cycle of direct transformations affords an elegant triangle of three mutually convertible N‐fused porphyrinoids, with distinct spectroscopic features: antiaromatic, nonaromatic and aromatic. The nonaromatic species has a dome shaped skeleton which forms in the solid state a ball and socket structure with C60.