bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between sensory processing and stress in the adult population: A systematic review
Authors: Harrold Aine , Keating Kim , Larkin Fionnuala , Setti Annalisa 
Published: June 2024

AbstractThere is emerging empirical evidence indicating that differences in self‐reported sensory processing may be associated with differences in levels of stress in the adult populations. Understanding how sensory processing relates to stress is of clinical relevance, given the well‐established impact of stress on physical health, mental health and well‐being. Although several studies have examined the association between sensory processing and stress in adult populations, no published reviews have systematically summarised and synthesised these findings. We aimed to fill this gap by conducting a systematic review to synthesise the available evidence examining the association between self‐reported sensory processing and self‐reported measures of stress in the adult population. The review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA‐S) checklist. Twenty studies were included in the final review. Quality assessment was conducted with the Mixed Methods Appraisal Tool. Overall, the evidence is strong for an association between differences in sensory processing and self‐reported stress in adults. This association was found across a range of populations and measures of stress, in cross‐sectional studies. The most commonly used measure of sensory processing was the Highly Sensitive Person Scale, which was consistently moderately associated with a range of measures of stress. The quality of the included studies was generally good, with most meeting four or five out of five criteria. Longitudinal studies are lacking. There is strong evidence for a cross‐sectional association between sensory processing and stress in an adult population. Further research, in particular longitudinal studies and studies including clinical populations, would be of benefit in order to establish causality.
Sustainable supply chains – Designing a requisite holistic model
Authors: Perko Igor , del Gaudio Giovanna , Potocan Vojko 
Published: June 2024

AbstractOur study explored the relationships between supply chain (SC) members and their local and global stakeholders in achieving sustainability goals based on requisite holistic analysis and system dynamics modeling, which goes beyond the previous attempts to improve SC sustainability. In this research, we first developed a model that addresses the basic holistic treatment of SC sustainability; in a second model of sustainable SC (SSC), we then considered requisite holistic interactions among its stakeholders. We used the theory‐based viable system model to diagnose the proposed holistic model of SSC. The results show that especially the low‐tier SC members require supporting frameworks to develop and maintain the capacity for sustainable interactions with nature and society. These supportive frameworks should be provided by the regulatory bodies, society, and nature representatives to surpass the limited SC profit‐oriented incentives and structures. The implications of the proposed models are aimed at developing supportive SC sustainable policies and improving the capacities of SC members to coexist with local social and natural environments. Regulators, society, and the natural environment representatives can apply the proposed models to establish new policies for sustainable interactions between SC members and other societal stakeholders.
A phase II trial of apalutamide for intermediate‐risk prostate cancer and molecular correlates
Authors: Hahn Andrew W. , Manyam Ganiraju C. , Chapin Brian F. , Zhang Miao , Yu Yao , Pettaway Curtis A. , Chery Lisly , Pisters Louis L. , Ward John F. , Gregg Justin R. , Papadopoulos John , Kamat Ashish M. , Lozano Marisa , Hoang Anh , Broom Bradley , Wang Xuemei , Huff Chad D. , Logothetis Christopher J. , Troncoso Patricia , Pilié Patrick G. , Davis John W. 
Published: June 2024

ObjectivesTo determine whether 6 months of preoperative apalutamide for intermediate‐risk prostate cancer (IRPCa) reduces the aggregate postoperative radiotherapy risk and to evaluate associations of molecular perturbations with clinical outcomes in this study cohort.Patients and MethodsBetween May 2018 and February 2020, eligible patients with IRPCa (Gleason 3 + 4 or 4 + 3 and clinical T2b‐c or prostate‐specific antigen level of 10–20 ng/mL) were treated with apalutamide 240 mg/day for 6 months followed by radical prostatectomy (RP) in this single‐arm, phase II trial. The primary endpoint was presence of any adverse pathological feature at risk of pelvic radiation (pathological T stage after neoadjuvant therapy [yp]T3 or ypN1 or positive surgical margins). Translational studies, including germline and somatic DNA alterations and RNA and protein expression, were performed on post‐apalutamide RP specimens, and assessed for associations with clinical outcomes.ResultsA total of 40 patients underwent a RP, and only one patient discontinued apalutamide prior to 6 months. In all, 40% had adverse pathological features at time of RP, and the 3‐year biochemical recurrence (BCR) rate was 15%, with 27.5% being not evaluable. Genomic alterations frequently seen in metastatic PCas, such as androgen receptor (AR), tumour protein p53 (TP53), phosphatase and tensin homologue (PTEN), or BReast CAncer associated gene (BRCA1/2) were underrepresented in this localised cohort. Adverse pathological features and BCR at 3‐years were associated with increased expression of select cell cycle (e.g., E2F targets: adjusted P value [Padj] < 0.001, normalised enrichment score [NES] 2.47) and oxidative phosphorylation (Padj < 0.001, NES 1.62) pathways.ConclusionsPreoperative apalutamide did not reduce the aggregate postoperative radiation risk to the pre‐specified threshold in unselected men with IRPCa. However, transcriptomic analysis identified key dysregulated pathways in tumours associated with adverse pathological outcomes and BCR, which warrant future study. Further investigation of preoperative therapy is underway for men with high‐risk PCa.
The relationship between video games and social–emotional delay in Chinese rural preschoolers: A comparison of five types of media
Authors: Gou He , Yang Yinglong 
Published: June 2024

AbstractBackgroundRecent studies have revealed a negative relationship between children's digital media use and social–emotional development. However, few studies distinguish between different digital devices and the different functions they provide that may lead to different outcomes.MethodsThis study explored the relationship between young children's time spent on various digital devices and their social–emotional delay based on a survey of 1182 preschoolers (3 to 6 years old) in rural China. Children's social–emotional delay was assessed through a validated screening tool (ASQ‐SE II).ResultsChildren's time spent on television, computers, tablets, or smartphones was not associated with their social–emotional delay. However, their risk of social–emotional delay increased as their time spent on game consoles increased. This relationship was reflected in five of the seven behavioural areas of children's social–emotional development (i.e., self‐regulation, compliance, affect, social communications, and interactions with people). Moreover, it did not vary between children with different socioeconomic statuses.ConclusionsThis study suggests a possible relationship between children's social–emotional delay and video games, which might need to be paid more attention to than other media types.
Residential Status Disparities in Social Participation and Quality of Life Among Chinese Children: The Mediating Role of Social Skills and Smartphone Addiction
Authors: Xu Shuo , Li Chunkai 
Published: June 2024

ABSTRACTThe relationship between social participation and quality of life (QoL) remains unclear, and scant investigation has been conducted to explore its underlying mechanisms. This study is aimed at elucidating this connection among Chinese children, emphasizing the mediating roles of social skills and smartphone addiction, alongside the moderating effect of residential status. Data was gathered from Huai'an, Jiangsu Province, comprising 639 children (53.7% girls), aged between 12 and 18 years (mean age = 15 years, SD = 1.65). Results indicated that social participation was positively associated with children's QoL, with both social skills and smartphone addiction mediating the link. Additionally, residential status moderated the relationship between social participation and QoL, exhibiting a stronger effect on children in urban areas than their rural counterparts. These findings highlight the necessity to enhance social participation among children and further promote balanced development between rural and urban areas in China.
The impact of the European Society of Cardiology guidelines and whole exome sequencing on genetic testing in hereditary cardiac diseases
Authors: Mio Catia , Zucco Jessica , Fabbro Dora , Bregant Elisa , Baldan Federica , Allegri Lorenzo , D'Elia Angela Valentina , Collini Valentino , Imazio Massimo , Damante Giuseppe , Faletra Flavio 
Published: June 2024

AbstractIn the last decade, an incredible improvement has been made in elucidating the genetic bases of cardiomyopathies. Here we report the impact of either the European Society of Cardiology (ESC) guidelines or the use of whole exome sequencing (WES) in terms of a number of variants of uncertain significance (VUS) and missed diagnoses in a series of 260 patients affected by inherited cardiac disorders. Samples were analyzed using a targeted gene panel of 128 cardiac‐related genes and/or WES in a subset of patients, with a three‐tier approach. Analyzing (i) only a subset of genes related to the clinical presentation, strictly following the ESC guidelines, 20.77% positive test were assessed. The incremental diagnostic rate for (ii) the whole gene panel, and (iii) the WES was 4.71% and 11.67%, respectively. The diverse analytical approaches increased the number of VUSs and incidental findings. Indeed, the use of WES highlights that there is a small percentage of syndromic conditions that standard analysis would not have detected. Moreover, the use of targeted sequencing coupled with “narrow” analytical approach prevents the detection of variants in actionable genes that could allow for preventive treatment. Our data suggest that genetic testing might aid clinicians in the diagnosis of inheritable cardiac disorders.
B‐cell immune deficiency in twin sisters expands the phenotype of MOPDI
Authors: Gauthier Lucas W. , Gossez Morgane , Malcus Christophe , Viel Sébastien , Monneret Guillaume , Bordonné Remy , Pons Linda , Cabet Sara , Delous Marion , Mazoyer Sylvie , Putoux Audrey , Edery Patrick 
Published: June 2024

AbstractMicrocephalic osteodysplastic primordial dwarfism type I (MOPDI) is a very rare and severe autosomal recessive disorder characterized by marked intrauterine growth retardation, skeletal dysplasia, microcephaly and brain malformations. MOPDI is caused by biallelic mutations in RNU4ATAC, a non‐coding gene involved in U12‐type splicing of 1% of the introns in the genome, which are recognized by their specific splicing consensus sequences. Here, we describe a unique observation of immunodeficiency in twin sisters with mild MOPDI, who harbor a novel n.108_126del mutation, encompassing part of the U4atac snRNA 3′ stem‐loop and Sm protein binding site, and the previously reported n.111G>A mutation. Interestingly, both twin sisters show mild B‐cell anomalies, including low naive B‐cell counts and increased memory B‐cell and plasmablasts counts, suggesting partial and transitory blockage of B‐cell maturation and/or excessive activation of naive B‐cells. Hence, the localization of a mutation in stem II of U4atac snRNA, as observed in another RNU4ATAC‐opathy with immunodeficiency, that is, Roifman syndrome (RFMN), is not required for the occurrence of an immune deficiency. Finally, we emphasize the importance of considering immunodeficiency in MOPDI management to reduce the risk of serious infectious episodes.
‘It can be an abuse, even though both have consented’: Swedish preschool practitioners' discussions about teaching (sexual) consent to preschoolers
Authors: Hulth Magdalena 
Published: June 2024

AbstractThis article describes how (sexual) consent is constructed as an objective for teaching in Swedish preschool. An age‐critical analysis of focus‐group discussions with preschool practitioners shows how a didactic of consent is constructed and characterised: (1) The child should be trained to feel non‐ambivalence. (2) Prohibitions are created against acts not considered age‐appropriate. (3) Age‐appropriate prior knowledge is required for a child's consent to be considered valid. Finally, alternative didactics of consent is discussed, in which ambivalence and unpredictability are highlighted as important elements.
Planning for a future of changes: Prioritising areas for conservation of small mammals in the Caatinga, Brazil
Authors: da Costa‐Pinto Anna Ludmilla , Kujala Heini , Bovendorp Ricardo S. , Malhado Ana Cláudia , Ladle Richard J. 
Published: June 2024

AbstractAimHuman land‐use and climate change are two of the main threats affecting biodiversity, especially in arid/semiarid regions. The most effective way to protect the species in these ecosystems against these threats is through the delimitation of protected areas (PAs). However, such PAs need to be targeted cost‐efficiently and consider future climate change. We identify priority areas to preserve small mammal species in the Caatinga in the present and in a future of climate changes. We also evaluate how well these priority areas are protected by currently PAs and identify ways forward to improve their protection.LocationThe Caatinga Dry Forest, Northeast Brazil.MethodsWe use ecological niche models and Zonation spatial prioritisation software to identify the top 30% priority areas to preserve small mammal species under current climate and land use scenarios, besides considering optimistic and pessimistic scenarios of future climate change. We also evaluate how much these priority areas are covered by current PAs, identify ways to further improve their protection using hierarchical mask analysis, and by evaluating species mean distribution coverage.ResultsThe consequences of climate change will not hugely impact the distribution of priority areas for species conservation in the Caatinga. Around 13% of the identified priority areas overlap with current PAs, and planning the expansion of PAs considering integral protection areas increases the coverage of priority areas to more than 18% and captures more than 72% of species suitable area.Main ConclusionsOur prioritisations take into account climate change and provide low risk if conducted as a ‘no‐regrets’ conservation action. These priority areas are poorly supported by the Brazilian PA system, and need of further protection. One cost‐effective option could be to upgrade some sustainable use PAs into more restrictive ones. Securing these priority areas helps preserve the long‐term ecosystem functioning and to prevent biodiversity loss in a changing world.
Children's gender essentialism and prejudice: Testing causal links via an experimental manipulation
Authors: Gross E. B. , Fine Rachel D. , Gülgöz Selin , Olson Kristina R. , Gelman Susan A. 
Published: June 2024

AbstractDespite increases in visibility, gender‐nonconforming young people continue to be at risk for bullying and discrimination. Prior work has established that gender essentialism in children correlates with prejudice against people who do not conform to gender norms, but to date no causal link has been established. The present study investigated this link more directly by testing whether children's gender essentialism and prejudice against gender nonconformity can be reduced by exposure to anti‐essentialist messaging. Children ages 6–10 years of age (N = 102) in the experimental condition viewed a short video describing similarities between boys and girls and variation within each gender; children in the control condition (N = 102) viewed a corresponding video describing similarities between two types of climate and variation within each. Children then received measures of gender essentialism and prejudice against gender nonconformity. Finally, to ask whether manipulating children's gender essentialism extends to another domain, we included assessments of racial essentialism and prejudice. We found positive correlations between gender essentialism and prejudice against gender nonconformity; both also correlated negatively with participant age. However, we observed no differences between children in the experimental versus control conditions in overall essentialism or prejudice, indicating that our video was largely ineffective in manipulating essentialism. Accordingly, we were unable to provide evidence of a causal relationship between essentialism and prejudice. We did, however, see a difference between conditions on the discreteness measure, which is most closely linked to the wording in the video. This finding suggests that specific aspects of essentialism in young children may be modifiable.Research Highlights
Consistent with prior research, we found that greater gender essentialism was associated with greater prejudice against gender‐nonconforming children; both decreased with age.
We randomly assigned children to view either an anti‐essentialist video manipulation or a control video to test if this relation was causal in nature.
The anti‐essentialist video did not reduce overall essentialism as compared to the control, so we did not find support for a causal link.
We observed a reduction in the dimension of essentialism most closely linked to the anti‐essentialist video language, suggesting the potential utility of anti‐essentialist messaging.
Reliability of energy landscape analysis of resting‐state functional MRI data
Authors: Khanra Pitambar , Nakuci Johan , Muldoon Sarah , Watanabe Takamitsu , Masuda Naoki 
Published: June 2024

AbstractEnergy landscape analysis is a data‐driven method to analyse multidimensional time series, including functional magnetic resonance imaging (fMRI) data. It has been shown to be a useful characterization of fMRI data in health and disease. It fits an Ising model to the data and captures the dynamics of the data as movement of a noisy ball constrained on the energy landscape derived from the estimated Ising model. In the present study, we examine test–retest reliability of the energy landscape analysis. To this end, we construct a permutation test that assesses whether or not indices characterizing the energy landscape are more consistent across different sets of scanning sessions from the same participant (i.e. within‐participant reliability) than across different sets of sessions from different participants (i.e. between‐participant reliability). We show that the energy landscape analysis has significantly higher within‐participant than between‐participant test–retest reliability with respect to four commonly used indices. We also show that a variational Bayesian method, which enables us to estimate energy landscapes tailored to each participant, displays comparable test–retest reliability to that using the conventional likelihood maximization method. The proposed methodology paves the way to perform individual‐level energy landscape analysis for given data sets with a statistically controlled reliability.
Trends in management of patients with new‐onset refractory status epilepticus (NORSE) from 2016 to 2023: An interim analysis
Authors: Hanin Aurelie , Jimenez Anthony D. , Gopaul Margaret , Asbell Hannah , Aydemir Seyhmus , Basha Maysaa Merhi , Batra Ayush , Damien Charlotte , Day Gregory S. , Eka Onome , Eschbach Krista , Fatima Safoora , Fields Madeline C. , Foreman Brandon , Gerard Elizabeth E. , Gofton Teneille E. , Haider Hiba A. , Hantus Stephen T. , Hocker Sara , Jongeling Amy , Kalkach Aparicio Mariel , Kandula Padmaja , Kang Peter , Kazazian Karnig , Kellogg Marissa A. , Kim Minjee , Lee Jong Woo , Marcuse Lara V. , McGraw Christopher M. , Mohamed Wazim , Orozco Janet , Pimentel Cederic M. , Punia Vineet , Ramirez Alexandra M. , Steriade Claude , Struck Aaron F. , Taraschenko Olga , Treister Andrew K. , Wainwright Mark S. , Yoo Ji Yeoun , Zafar Sahar , Zhou Daniel J. , Zutshi Deepti , Gaspard Nicolas , Hirsch Lawrence J. 
Published: June 2024

AbstractIn response to the evolving treatment landscape for new‐onset refractory status epilepticus (NORSE) and the publication of consensus recommendations in 2022, we conducted a comparative analysis of NORSE management over time. Seventy‐seven patients were enrolled by 32 centers, from July 2016 to August 2023, in the NORSE/FIRES biorepository at Yale. Immunotherapy was administered to 88% of patients after a median of 3 days, with 52% receiving second‐line immunotherapy after a median of 12 days (anakinra 29%, rituximab 25%, and tocilizumab 19%). There was an increase in the use of second‐line immunotherapies (odds ratio [OR] = 1.4, 95% CI = 1.1–1.8) and ketogenic diet (OR = 1.8, 95% CI = 1.3–2.6) over time. Specifically, patients from 2022 to 2023 more frequently received second‐line immunotherapy (69% vs 40%; OR = 3.3; 95% CI = 1.3–8.9)—particularly anakinra (50% vs 13%; OR = 6.5; 95% CI = 2.3–21.0), and the ketogenic diet (OR = 6.8; 95% CI = 2.5–20.1)—than those before 2022. Among the 27 patients who received anakinra and/or tocilizumab, earlier administration after status epilepticus onset correlated with a shorter duration of status epilepticus (ρ = .519, p = .005). Our findings indicate an evolution in NORSE management, emphasizing the increasing use of second‐line immunotherapies and the ketogenic diet. Future research will clarify the impact of these treatments and their timing on patient outcomes.