bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brief communication: Reevaluating osteoporosis in human ribs: The role of intracortical porosity
Authors: Agnew Amanda M. , Stout Sam D. 
Published: March 2012

AbstractOsteoporosis is a major health concern in modern society and is continually being evaluated in past populations by quantifying bone loss. Cortical area measures are commonly used in anthropological analyses to assess bone loss in the ribs, but these values are typically based on endosteal expansion and do not account for intracortical bone loss. The objective of this study is to evaluate the effectiveness of using absolute cortical area, compared to traditional cortical area measures to describe global bone loss in elderly ribs. Transverse sections were prepared from sixth ribs of ten elderly subjects, and bone area measurements were made from 100× magnification composites of each rib for calculation of cortical area (Ct.Ar) and percent cortical area (% C/T). In addition, all areas of intracortical porosity were measured and percent porosity area (% Po.Ar) calculated. Absolute cortical area (Ct.ArA) was calculated by subtracting porosity area from cortical area, and a percent absolute cortical area (% CA/T) calculated. ANOVA results reveal significant interindividual variation in percent porosity area (% Po.Ar). Percent cortical area and percent absolute cortical area values were compared and results show a mean difference of 4.08% exists across all subjects, with a range of 1.19–11.73%. This suggests that intracortical porosity is variable and does play a role in age‐associated bone loss in the rib. All future investigations of osteoporosis should account for intracortical porosity in bone loss. Am J Phys Anthropol 148:462–466, 2012. © 2012 Wiley Periodicals, Inc.
Tensile properties of phenol–formaldehyde nanoclay reinforced composites: A pilot study
Authors: Ku H. , Yap Y. S. , Lee T. S. , Trada M 
Published: March 2012

AbstractPhenol–formaldehyde was filled with nanoclay to increase the tensile properties of the composite for structural applications by the Centre of Excellence in Engineered Fiber Composites, University of Southern Queensland, Australia. In this project, we manufactured samples with different percentages by weight of the nanoclay in the composites in steps of 1%; these were then postcured in an oven or microwaves. The samples were then subjected to tensile tests. The results show that the composite with 5 wt % nanoclay produced the highest yield, tensile strength, and Young's modulus, combined with a reasonable fluidity for casting. From 0 to 3 wt % nanoclay, the yield strengths of the samples postcured in an oven were higher than their counterparts postcured in microwaves. After this, the opposite was true. By extrapolation to 5 wt % nanoclay, it was also found that the tensile strength and Young's modulus of the samples postcured in an oven were lower than their counterparts postcured in microwave irradiation. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Surface modification of siloxane containing polyurethane polymer by dielectric barrier discharge at atmospheric pressure
Authors: Kostov K. G. , dos Santos A. L. R. , Nascente P. A. P. , Kayama M. E. , Mota R. P. , Algatti M. A. 
Published: March 2012

AbstractSurface treatment of polymers by discharge plasmas is of great and increasing industrial application because it can uniformly modify the surface of treated samples without changing the material bulk properties. Present work deals with surface modification of siloxane‐containing polyurethane (PU‐Si) by air dielectric barrier discharge (DBD) at atmospheric pressure. Material characterization was carried out by contact angle measurements, atomic force microscopy (AFM), and X‐ray photoelectron spectroscopy (XPS). The surface energy of the polymer surface was calculated from contact angle data using Owens‐Wendt‐Kaeble method. The plasma‐induced chemical modifications are associated with incorporation of polar oxygen containing groups on the polymer surface. The AFM analysis of DBD‐treated samples revealed that the surface roughness decreased with increasing the time of treatment. Because of the plasma exposure the surface of DBD‐treated polymers became hydrophilic resulting in enhanced adhesion properties. Aging behavior of the treated samples revealed that all polymer surfaces were prone to hydrophobic recovery; however, they did not completely recover their original hydrophobic characteristics. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Microbial manipulation of host sex determination
Authors: Beukeboom Leo W. 
Published: March 2012

AbstractA recent study in the lepidopteranOstrinia scapulalisshows that endosymbionts can actively manipulate the sex determination mechanism of their host.Wolbachiabacteria alter the sex‐specific splicing of thedoublesexmaster switch gene. In ZZ males of this female heterogametic system, the female isoform ofdoublesexis produced in the presence of the bacteria. The effect is a lethal feminization of genotypic males. Curing of ZW females leads to males that die, indicating that the bacteria have an obligate role in proper sex determination and development of their host. Microbial intervention with host sex determination may be a driving force behind the evolutionary turnover of sex determination mechanisms.
Retinoids for treatment of Alzheimer's disease
Authors: Lerner Alan J. , Gustaw‐Rothenberg Kasia , Smyth Shawn , Casadesus Gemma 
Published: March 2012

AbstractRetinoids are Vitamin A derivatives involved in cellular regulatory processes including cell differentiation, neurite outgrowth and defense against oxidative stress. Retinoids may also influence Amyloid beta processing upregulation of alpha secretase via ADAM10. Vitamin A and other retinoids also directly inhibit formation of Amyloid fibrils in vivo. These properties of retinoids are relevant to theories of Alzheimer's disease pathogenesis. Retinoids are already used in treatment of acne vulgaris, psoriasis, neuroblastoma and acute promyelocytic leukemia. Clinical studies involving in cognitively impaired older adults with Alzheimer's disease are beginning with a variety of retinoids. These studies need to address safety issues of retinoids in older populations, and hold hope for demonstrating efficacy in translating these basic mechanisms to treatment of a widespread dementing illness.
Closure of the patent ductus arteriosus with the new duct occluder II additional sizes device
Authors: Agnoletti Gabriella , Marini D. , Villar A.M. , Bordese R. , Gabbarini F. 
Published: March 2012

AbstractObjectiveThe objective of this study was to evaluate the technical feasibility, safety, and efficacy of the new device Amplatzer duct occluder II additional sizes (ADO II AS) for closure of patent ductus arteriosus (PDA). Background: Transcatheter device closure is the standard care for PDA. Currently available technology is not designed for closure of small PDA in young children.MethodsFrom April to July 2011, seven children (five females, median age 1.5 years, median weight 11.4 kg) underwent PDA closure with the ADO II AS. Six had isolated PDA, one had PDA associated with preductal coarctation. We evaluated early and short‐term results.ResultsAll but one PDA was closed via an antegrade approach. Mean fluoroscopy and procedural times were 8.0 ± 3.9 and 49.8 ± 27.9 min, respectively. No complications occurred. Immediate trivial residual shunt was present in one patient. In all devices, the retention disks laid flat against the walls of the pulmonary artery and aorta, without protrusion into the vessel lumen. The echocardiography performed after 24 hr did not show any residual shunt. At a median follow‐up of 2 months, the PDAs were completely occluded without obstruction of the pulmonary arteries or aorta.ConclusionsThe new device ADO II AS was safely deployed with complete resolution of the PDA shunt. The lower profile and symmetry of this device allows for venous or arterial approach and smaller delivery catheter size. The ADO II AS might be a preferable alternative for closure of small‐moderate PDAs. © 2012 Wiley Periodicals, Inc.
Bonding in a Borylene Complex Investigated by Photoionization and Dissociative Photoionization
Authors: Fischer Kathrin H. , Schneider Michael , Fischer Ingo , Pfaffinger Bernd , Braunschweig Holger , Sztáray Bálint , Bodi Andras 
Published: March 2012

AbstractThe borylene complex [(OC)5CrBN(SiMe3)2] has been investigated by using threshold photoelectron–photoion coincidence spectroscopy with synchrotron radiation. The ionization energy of the parent complex and the 0 K appearance energies of the sequential CO loss channels have been determined. The derived bond‐dissociation energies are used to discuss bonding and energetics in this compound.
ChemInform Abstract: Studies of the Synthesis of Nicotinamide Nucleoside and Nucleotide Analogues and Their Inhibitions Towards CD38 NADase.
Authors: Chen Zhe , Kwong Anna Ka Yee , Yang Zhenjun , Zhang Liangren , Lee Hon Cheung , Zhang Lihe 
Published: March 2012

AbstractPhosphorylation of nicotine amid nucleosides as (III) or (VI) lowers the inhibitory activity towards CD 38 NADase.
Efficient Copper(I)‐Catalyzed S‐Arylation of KSCN with Aryl Halides in PEG‐400
Authors: Li Xiaokang , Yuan Tangjun , Chen Junmin 
Published: March 2012

AbstractA simple and efficient protocol for CuI‐catalyzed CS bond formation of aryl halides with KSCN to symmetrical diaryl sulfides was reported in PEG‐400 without any other additives. A variety of aryl halides were converted to the corresponding diaryl sulfides in good to excellent yields. The present procedure tolerated a variety of functional groups and the steric hindrance of ortho‐substituents on aryl halides did not affect the outcome.
Density Functional Theory Study of the Interaction between Thymine and Luteolin
Authors: Wang Xiaolan , Cai Wanfei , Zheng Yan , Li Laicai , Tian Anmin 
Published: March 2012

AbstractThe density function B3LYP method has been used to optimize the geometries of the luteolin, thymine and luteolin‐thymine complexes at 6‐31+G∗︁ basis. The vibrational frequencies have been studied at the same level to analyze these seventeen complexes, respectively. Theories of atoms in molecules (AIM) and natural bond orbital (NBO) have been utilized to investigate the hydrogen bonds involved in all the systems. The interaction energies of the complexes corrected by basis set superposition error are between −93.00–−76.69 kJ/mol. The calculating results indicate that strong hydrogen bonding interactions have been found in the luteolin‐thymine complexes.
Dinuclear MnIII Compounds [{Mn(bpy)(H2O)}2(μ‐4‐RC6H4COO)2(μ‐O)](NO3)2 (R = Me, F, CF3, MeO, tBu): Effect of the R Group on the Magnetic Properties and the Catalase Activity
Authors: Corbella Montserrat , Fernández Gema , González Patricia , Maestro Miguel , Font‐Bardia Mercè , Stoeckli‐Evans Helen 
Published: March 2012

AbstractFive new dinuclear MnIII compounds [{Mn(bpy)(H2O)}2(μ‐4‐RC6H4COO)2(μ‐O)](NO3)2 [R = Me (1), F (2), CF3 (3), MeO (4) and tBu (5); bpy = 2,2′‐bipyridine] have been synthesized; compounds 1–3 have been characterized by X‐ray diffraction. Moreover, a few crystals of the MnIII compound[{Mn(bpy)(H2O)}(μ‐4‐FC6H4COO)(μ‐O){Mn(NO3)(bpy)(H2O)}](NO3)2 (6) have been obtained. Variable‐temperature magnetic susceptibility data of 1–5 were recorded; all compounds show ferromagnetic behaviour with J = 1.48 cm–1 for 1, 1.44 cm–1 for 2, 5.66 cm–1 for 3, 3.22 cm–1 for 4 and 2.68 cm–1 for 5 (H = –JS1·S2); and |DMn| = 1.5 cm–1 and |EMn| = 0.5 cm–1 for all compounds except for 2, for which these values are 2.85 and 0.7 cm–1, respectively. The coordination octahedron around the MnIII ions shows a rhombic distortion due to the coordination of a water molecule. This kind of distortion and the R group of the benzoato–derivative bridge in a para position favour ferromagnetic behaviour. Moreover, the presence of an electron‐withdrawing substituent increases this magnetic character. All compounds show catalase activity with a conversion range between 20 and 55 % of the initial H2O2 within 10 min. Compounds 4, 5 and 3 with an electron‐donating R group are more efficient than 2, 3 with electron‐withdrawing groups.
Label‐Free Electrochemical Imaging of Latent Fingerprints on Metal Surfaces
Authors: Qin Gang , Zhang Meiqin , Zhang Ting , Zhang Yang , McIntosh Mike , Li Xiao , Zhang Xueji 
Published: March 2012

AbstractA label‐free electrochemical method based on scanning electrochemical microscopy (SECM) has been developed to image latent fingerprints with high resolution on five kinds of metal surfaces (platinum, gold, silver, copper and stainless steel), as it could measure the minor conductivity differences of the substrate surface and avoid the interference of the background‐color. The images of sebaceous fingerprints on clean metals were revealed by SECM with ferrocene methanol acting as a redox mediator to detect the topology of the fingerprint deposits in constant‐height feedback mode. Inhibition of electrochemical processes on areas of the surface masked by the insulating fingerprint residues generated a negative image of the fingerprint.
A ZFN/ piggyBac step closer to autologous liver cell therapy
Authors: Mattis Aras N. , Willenbring Holger 
Published: March 2012

Abstract

Human induced pluripotent stem cells (iPSCs) represent a unique opportunity for regenerative medicine because they offer the prospect of generating unlimited quantities of cells for autologous transplantation, with potential application in treatments for a broad range of disorders. However, the use of human iPSCs in the context of genetically inherited human disease will require the correction of disease-causing mutations in a manner that is fully compatible with clinical applications. The methods currently available, such as homologous recombination, lack the necessary efficiency and also leave residual sequences in the targeted genome. Therefore, the development of new approaches to edit the mammalian genome is a prerequisite to delivering the clinical promise of human iPSCs. Here we show that a combination of zinc finger nucleases (ZFNs) and

piggyBac

technology in human iPSCs can achieve biallelic correction of a point mutation (Glu342Lys) in the α1-antitrypsin (

A1AT
, also known as

SERPINA1

) gene that is responsible for α1-antitrypsin deficiency. Genetic correction of human iPSCs restored the structure and function of A1AT in subsequently derived liver cells

in vitro

and

in vivo
. This approach is significantly more efficient than any other gene-targeting technology that is currently available and crucially prevents contamination of the host genome with residual non-human sequences. Our results provide the first proof of principle, to our knowledge, for the potential of combining human iPSCs with genetic correction to generate clinically relevant cells for autologous cell-based therapies.
Prognostic influence of BCL2 expression in breast cancer
Authors: Hwang Ki‐Tae , Woo Jung Woo , Shin Hee Chul , Kim Han Suk , Ahn Soo Kyung , Moon Hyeong‐Gon , Han Wonshik , Park In Ae , Noh Dong‐Young 
Published: March 2012

AbstractAlthough BCL2 has occasionally been suggested as a candidate prognostic factor for breast cancer, it is still not accepted as a prognostic factor. We attempted to validate the role of BCL2 as a prognostic factor of breast cancer. Data on 7,230 primary breast cancer patients from the Seoul National University Hospital Breast Care Center were analyzed. Three current prognostic models, including the St. Gallen model, the Nottingham prognostic index (NPI) model and the TNM model, were used for analysis of the prognostic influence of BCL2. The positive BCL2 group showed more favorable features with regard to clinicopathologic parameters than the BCL2 negative group and a strong correlation was observed between BCL2 and the hormonal receptor. The positive BCL2 group showed better prognosis in overall survival and disease free survival (log‐rank test, both p < 0.001), even in all subgroups, than the BCL2 negative group. BCL2 was a significant prognostic factor in both univariate (hazard ratio [HR], 0.361; 95% confidence interval (CI), 0.306–0.426; p < 0.001) and multivariate analyses (HR, 0.417; 95% CI, 0.417–0.705; p < 0.001). BCL2 had a strong influence on the established prognostic models, including the St. Gallen model, the NPI model and the TNM model. BCL2 was a powerful independent prognostic factor for breast cancer and had a strong influence on the current prognostic models. Favorable clinicopathologic features and a strong correlation with the hormonal receptor are suggested as the causes of superior survival in patients with BCL2 positive breast cancer.
Diagnosis of the performance of the state‐specific multireference coupled‐cluster method with different truncation schemes
Authors: Mahapatra Uttam Sinha , Chattopadhyay Sudip 
Published: March 2012

AbstractWe have tested the linked version of a iterative (partial) triples correction for the Jeziorski‐Monkhorst ansatz based state‐specific multireference coupled cluster (SS‐MRCC) approach with singles and doubles (SD) excitations [abbreviated as SS‐MRCCSDT‐1a and SS‐MRCCSDT‐1a+d]. The assessments of SS‐MRCCSDT‐1a and SS‐MRCCSDT‐1a+d schemes have been performed on the ground potential energy surface (PES) of P4, ${\rm Li}_2$, and ${\rm Be}_2$ systems which demand the MR description, and on study of the excitation energy between the ground and first excited state for P4 system. Illustrations in the isomerization of cyclobutadiene also show the power of the schemes. One of the designed features of the SS‐MRCCSDT‐n methods introduced here is that they do not require storage of the triples amplitudes. In the entire range of geometries, we found a definite improvement provided by SS‐MRCC with SDT‐1a and SDT‐1a+d schemes over the standard SD one. In the nondegenerate regions of PES, the closeness of the performance of the single‐reference CC to the SS‐MRCC methods increases after inclusion of even partial triple excitations. Generally, the performance of the SS‐MRCCSDT‐1a+d approach is closer to the corresponding full configuration interaction (FCI) one than to the SS‐MRCCSDT‐1a specially in the degenerate geometries (as is evident from nonparallelism error). The deviation from FCI for the first excited state of the P4 model using various SS‐MRCC theories with different truncation schemes obtained by converging on the second root of the effective Hamiltonian has also been reported. We also compare our results with the current generation state‐of‐the‐art single and multireference CC calculations to envisage the usefulness of the present approach. Initial implementation indicates that the SS‐MRCCSDT‐n formalism can provide not only reliable excitation energies and barrier height even when used in a relatively small model space, but also offers a considerable promise in generating the entire energy surface with low nonparallelity error. © 2012 Wiley Periodicals, Inc.
Testing a Model of Research Intention Among U.K. Clinical Psychologists: A Logistic Regression Analysis
Authors: Eke Gemma , Holttum Sue , Hayward Mark 
Published: March 2012

ObjectivesPrevious research highlights barriers to clinical psychologists conducting research, but has rarely examined U.K. clinical psychologists. The study investigated U.K. clinical psychologists’ self‐reported research output and tested part of a theoretical model of factors influencing their intention to conduct research.MethodsQuestionnaires were mailed to 1,300 U.K. clinical psychologists.ResultsThree hundred and seventy‐four questionnaires were returned (29% response‐rate). This study replicated in a U.K. sample the finding that the modal number of publications was zero, highlighted in a number of U.K. and U.S. studies. Research intention was bimodally distributed, and logistic regression classified 78% of cases successfully. Outcome expectations, perceived behavioral control and normative beliefs mediated between research training environment and intention.ConclusionsFurther research should explore how research is negotiated in clinical roles, and this issue should be incorporated into prequalification training.
Surrogate modeling of microwave structures using kriging, co‐kriging, and space mapping
Authors: Couckuyt Ivo , Koziel Slawomir , Dhaene Tom 
Published: March 2012

SUMMARYSpace mapping (SM) is one of the most popular techniques for creating computationally cheap and reasonably accurate surrogates of electromagnetic‐simulated microwave structures (so‐called fine models) using underlying coarse models, typically equivalent circuits. One of the drawbacks of SM is that although good modeling accuracy can be obtained using a limited number of training points, SM is not capable of efficiently utilizing larger amount of fine model information, even if it is available. In this paper, we consider various ways of enhancing SM surrogates by exploiting additional training data as well as two function approximation methodologies, kriging and co‐kriging. To our knowledge, it is the first application of co‐kriging for microwave circuit modeling. With three examples of microstrip filters, we present a comprehensive numerical study in which we compare the accuracy of the basic SM models as well as SM enhanced by kriging and co‐kriging. Direct kriging interpolation of fine model data is used as a reference. Copyright © 2012 John Wiley & Sons, Ltd.
Phosphorylation of serine 774 of the neural cell adhesion molecule is necessary for cyclic adenosine monophosphate response element binding protein activation and neurite outgrowth
Authors: Pollscheit Juliane , Glaubitz Nicole , Haller Hannes , Horstkorte Rüdiger , Bork Kaya 
Published: March 2012

AbstractThe neural cell adhesion molecule (NCAM) plays a fundamental role during development and regeneration. NCAM is expressed in three major isoforms, two of them with intracellular domains of different length and one without any intracellular domain. The cytoplasmic domain of NCAM contains, depending on the isoform, up to 49 phosphorylation sites, and it has been demonstrated previously by phosphoproteomic analysis that NCAM is phosphorylated on serine 774. However, the impact of NCAM phosphorylation is unclear. Here we have analyzed the phosphorylation of serine 774 in more detail and found that phosphorylation of this site is crucial for NCAM‐mediated signal transduction. A serine‐to‐alanine exchange at position 774 (NCAM140‐S774A) resulted in decreased activation of the cAMP response element binding protein (CREB) after NCAM stimulation and, as a consequence, in decreased neurite outgrowth of NCAM140‐S774A‐transfected B35 neuroblastoma cells. © 2012 Wiley Periodicals, Inc.
Electrocrystallisation of (perylene)2[M(mnt)2] salts
Authors: Afonso Mónica L. , Silva Rafaela A. L. , Matos Manuel , Henriques Rui T. , Almeida Manuel 
Published: March 2012

AbstractThe study of the family of compounds α‐(Per)2[M(mnt)2], (M = Cu, Au, Ni, Pd, Pt, Co, Fe) has started more than 30 years ago with the report of first members, but has been always limited by difficulties in the growth of high quality and large single crystals. These compounds can be obtained by oxidation of perylene in the presence of anion salts, either with iodine or electrochemically. The electrocrystallisation, which usually yields better quality crystals than the chemical oxidation route, has however several limitations and it is significantly more difficult to apply to these perylene compounds, which may present different stoichiometries and polymorphs, than to charge transfer salts of many other donors. These difficulties are associated with the low solubility of perylene and the instability of its radical cation in solution. The results of a systematic study to optimise the growth conditions of these compounds by electrocrystallisation and to identify key factors governing the formation of their different phases are presented. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)