bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interactions of ENSO, the IOD, and the SAM in CMIP3 Models
Authors: Cai Wenju , Sullivan Arnold , Cowan Tim 
Published: November 2010

Abstract
Simulations of individual global climate drivers using models from the Coupled Model Intercomparison Project phase 3(CMIP3) have been examined; however, the relationship among them has not been assessed. This is carried out to address several important issues, including the likelihood of the southern annular mode (SAM) forcing Indian Ocean dipole (IOD) events and the possible impact of the IOD on El Niño–Southern Oscillation (ENSO) events. Several conclusions emerge from statistics based on multimodel outputs. First, ENSO signals project strongly onto the SAM, although ENSO-forced signals tend to peak before ENSO. This feature is similar to the situation associated with the IOD. The IOD-induced signal over southern Australia, through stationary equivalent Rossby barotropic wave trains, peak before the IOD itself. Second, there is no control by the SAM on the IOD, in contrast to what has been suggested previously. Indeed, no model produces a SAM–IOD relationship that supports a positive (negative) SAM driving a positive (negative) IOD event. This is the case even in models that do not simulate a statistically significant relationship between ENSO and the IOD. Third, the IOD does have an impact on ENSO. The relationship between ENSO and the IOD in the majority of models is far weaker than the observed. However, the ENSO’s influence on the IOD is boosted by a spurious oceanic teleconnection, whereby ENSO discharge–recharge signals transmit to the Sumatra–Java coast, generating thermocline anomalies and changing IOD properties. Without the spurious oceanic teleconnection, the influence of the IOD on ENSO is comparable to the impact of ENSO on the IOD. Other model deficiencies are discussed.
Geographical Distribution of Climate Feedbacks in the NCAR CCSM3.0
Authors: Taylor Patrick C. , Ellingson Robert G. , Cai Ming 
Published: November 2010

Abstract
This study performs offline, partial radiative perturbation calculations to determine the geographical distributions of climate feedbacks contributing to the top-of-atmosphere (TOA) radiative energy budget. These radiative perturbations are diagnosed using monthly mean model output from the NCAR Community Climate System Model version 3 (CCSM3.0) forced with the Special Report Emissions Scenario (SRES) A1B emission scenario. The Monte Carlo Independent Column Approximation (MCICA) technique with a maximum–random overlap rule is used to sample monthly mean cloud frequency profiles to perform the radiative transfer calculations. It is shown that the MCICA technique provides a good estimate of all feedback sensitivity parameters. The radiative perturbation results are used to investigate the spatial variability of model feedbacks showing that the shortwave cloud and lapse rate feedbacks exhibit the most and second most spatial variability, respectively. It has been shown that the model surface temperature response is highly correlated with the change in the TOA net flux, and that the latter is largely determined by the total feedback spatial pattern rather than the external forcing. It is shown by representing the change in the TOA net flux as a linear combination of individual feedback radiative perturbations that the lapse rate explains the most spatial variance of the surface temperature response. Feedback spatial patterns are correlated with the model response and other feedback spatial patterns to investigate these relationships. The results indicate that the model convective response is strongly correlated with cloud and water vapor feedbacks, but the lapse rate feedback geographic distribution is strongly correlated with the climatological distribution of convection. The implication for the water vapor–lapse rate anticorrelation is discussed.
Thick Anvils as Viewed by the TRMM Precipitation Radar
Authors: Li Wei , Schumacher Courtney 
Published: November 2010

Abstract
This study investigates anvils from thick, nonprecipitating clouds associated with deep convection as observed in the tropics by the Tropical Rainfall Measuring Mission (TRMM) Precipitation Radar (PR) during the 10-yr period, 1998–2007. Anvils observable by the PR occur, on average, 5 out of every 100 days within grid boxes with 2.5° resolution and with a conditional areal coverage of 1.5%. Unconditional areal coverage is only a few tenths of a percent. Anvils also had an average 17-dBZ echo top of ∼8.5 km and an average thickness of ∼2.7 km. Anvils were usually higher and thicker over land compared to ocean, and occurred most frequently over Africa, the Maritime Continent, and Panama. Anvil properties were intimately tied to the properties of the parent convection. In particular, anvil area and echo-top heights were highly correlated to convective rain area. The next best predictor for anvil areal coverage and echo tops was convective echo tops, while convective reflectivities had the weakest correlation. Strong upper-level wind shear also may be associated with anvil occurrence over land, especially when convection regularly attains echo-top heights greater than 7 km. Some tropical land regions, especially those affected by monsoon circulations, experience significant seasonal variability in anvil properties—strong interannual anvil variability occurs over the central Pacific because of the El Niño–Southern Oscillation. Compared to the CloudSat Cloud Profiling Radar, the TRMM PR underestimates anvil-top height by an average of ∼5 km and underestimates their horizontal extent by an average factor of 4.
Estimating Annual Numbers of Atlantic Hurricanes Missing from the HURDAT Database (1878–1965) Using Ship Track Density
Authors: Vecchi Gabriel A. , Knutson Thomas R. 
Published: November 2010

Abstract
This study assesses the impact of imperfect sampling in the presatellite era (between 1878 and 1965) on North Atlantic hurricane activity measures and on the long-term trends in those measures. The results indicate that a substantial upward adjustment of hurricane counts may be needed prior to 1965 to account for likely “missed” hurricanes due to sparse density of reporting ship traffic. After adjusting for the estimate of missed hurricanes in the basin, the long-term (1878–2008) trend in hurricane counts changes from significantly positive to no significant change (with a nominally negative trend). The adjusted hurricane count record is more strongly connected to the difference between main development region (MDR) sea surface temperature (SST) and tropical-mean SST than with MDR SST. These results do not support the hypothesis that the warming of the tropical North Atlantic due to anthropogenic greenhouse gas emissions has caused Atlantic hurricane frequency to increase.
On the Climatology and Trend of the Atmospheric Heat Source over the Tibetan Plateau: An Experiments-Supported Revisit
Authors: Yang Kun , Guo Xiaofeng , He Jie , Qin Jun , Koike Toshio 
Published: November 2010

Abstract
Atmospheric heating over the Tibetan Plateau (TP) enhances the Asian summer monsoon. This study presents a state-of-the-art estimate of the heating components and their total over the TP, with the aid of high-accuracy experimental data, an updated land surface model, and carefully selected satellite data.
The new estimate differs from previous estimates in three aspects: 1) different seasonality—the new estimation shows the maximum total heat source occurs in July (the mature period of the monsoon), rather than in the previously reported month of May or June (around the onset of the monsoon), because previous studies greatly overestimated radiative cooling during the monsoon season [June–August (JJA)]; 2) different regional pattern—the eastern TP exhibits stronger heating than the western TP in summer, whereas previous studies gave either an opposite spatial pattern because of overestimated sensible heat flux over the western TP or an overall weaker heat source because of overestimated radiative cooling; and 3) different trend—sensible heat, radiative convergence, and the total heat source have decreased since the 1980s, but their weakening trends were overestimated in a recent study. These biases in previous studies are due to fairly empirical methods and data that were not evaluated against experimental data.
Modulation of North Pacific Tropical Cyclone Activity by Three Phases of ENSO
Authors: Kim Hye-Mi , Webster Peter J. , Curry Judith A. 
Published: November 2010

Abstract
Tropical Pacific Ocean warming has been separated into two modes based on the spatial distribution of the maximum sea surface temperature (SST) anomaly: an east Pacific warming (EPW) and a central Pacific warming (CPW). When combined with east Pacific cooling (EPC), these three regimes are shown to have different impacts on tropical cyclone (TC) activity over the North Pacific by differential modulation of both local thermodynamic factors and large-scale circulation patterns. In EPW years, the genesis and the track density of TCs tend to be enhanced over the southeastern part and suppressed in the northwestern part of the western Pacific by strong westerly wind shear. The extension of the monsoon trough and the weak wind shear over the central Pacific increases the likelihood of TC activity to the east of the climatological mean TC genesis location. In CPW years, the TC activity is shifted to the west and is extended through the northwestern part of the western Pacific. The westward shifting of CPW-induced heating moves the anomalous westerly wind and monsoon trough through the northwestern part of the western Pacific and provides a more favorable condition for TC landfall. The CPW, on the other hand, produces a large suppression of TC activity in the eastern Pacific basin. In EPC years, all of the variables investigated show almost a mirror image of the EPW.
The Interannual Relationship between the Latitude of the Eddy-Driven Jet and the Edge of the Hadley Cell
Authors: Kang Sarah M. , Polvani Lorenzo M. 
Published: November 2010

Abstract
A strong correlation between the latitudes of the eddy-driven jet and of the Hadley cell edge, on interannual time scales, is found to exist during austral summer, in both the NCEP–NCAR reanalysis and the models participating in the Coupled Model Intercomparison Project, phase 3 (CMIP3). In addition, a universal ratio close to 1:2 characterizes the robust connection between these two latitudes on a year-to-year basis: for a 2° shift of the eddy-driven jet, the edge of the Hadley cell shifts by 1°. This 1:2 interannual ratio remains the same in response to climate change, even though the values of the two latitudes increase. The corresponding trends are also highly correlated; in the CMIP3 scenario integrations, however, no universal ratio appears to exist connecting these long-term trends. In austral winter and in the Northern Hemisphere, no strong interannual correlations are found.
Effects of peri-operative glucose levels on adverse outcomes in infants receiving open-heart surgery for congenital heart disease with cardiopulmonary bypass
Authors: Song Lou  , Fan Ding  , Cun Long  , Jinping Liu  , Ju Zhao  , Zhengyi Feng  
Published: November 2010

O bjective: Studies designed to evaluate the association of hyperglycemia and adverse events in pediatric patients receiving open cardiac surgery have yielded inconsistent results. The aim of this retrospective, observational study was to evaluate the effects of peri-operative glucose levels on adverse events in infants receiving open-heart surgery with CPB. Methods: From Nov 2009 through Dec 2009, 100 infants undergoing open-heart surgery were enrolled. All glucose values during the operation and intensive care unit stay were documented. Metrics of glucose control, including mean, peak and minimum glucose levels were calculated. Hyperglycemia was defined as a mean glucose above 150mg/dl. Hypoglycemia was defined as minimum glucose below 65mg/dl. Multivariable regression analyses were used to determine relationships between these metrics of glucose control and a composite morbidity-mortality outcome after controlling for multiple variables known to influence early outcomes after congenital heart surgery. Results: According to our definition, 43 patients (43%) developed hyperglycemia and 9 patients (9%) developed at least one episode of hypoglycemia. A total of 58 patients reached the overall composite morbidity-mortality end point at some point during the study period. After adjusting the effects of age, cross-clamp time and pre-operative percutaneous oxygen saturation by multivariable analysis, euglycemia, defined as mean glucose ≤150mg/dl, was found to be a significant predictor for morbidity, with an odds ratio of 5.1(95% confidence interval 1.5-17.5). Conclusion: In contrast to adult critically ill patients, data from the present study did not prove that hyperglycemia was detrimental to infants receiving open-heart surgery with CPB. The existing literature and findings of our present study warranted future clinical studies of strict glycemic control in critically ill children, considering a more permissive glycemic range as a desirable target.
Myocardial perfusion imaging using a technetium-99m Sestamibi in asymptomatic and low risk for coronary artery disease patients with diagnosed systemic lupus erythematosus
Authors: Baharfard Nastaran , Mohammad Kazem Shiroodi  , Fotoohi Freidoon , Samangooie Shahdokht , Isa Neshandar Asli  , Eghtesadi-Araghi Payam , Javadi Hamid , Semnani Shahryar , Amini Azam , Assadi Majid 
Published: November 2010

Introduction: The aim of the present study was to evaluate technetium-99m sestamibi single photon emission tomography (SPECT) myocardial perfusion imaging (MPI) and its association with some clinical and laboratory parameters in an asymptomatic systemic lupus erythematosus (SLE) population. Materials and Methods : Twenty-one subjects with SLE and no suspected or documented coronary artery disease (CAD) accomplished myocardial perfusion imaging. Some SLE and CAD parameters were also evaluated in association with myocardial SPECT. Results: Twenty-one women with a diagnosis of SLE (mean age 36.9 ± 12.8) entered the study. All patients were in the low-risk category for CAD pretest; however, abnormal myocardial perfusion results were found in eight (38%) patients. Amongst the traditional CAD risk factors, there was a significant association between the presence of dyslipidemia and myocardial perfusion abnormalities (P= 0.047). However, we found no significant association between other traditional and SLE-specific risk factors. Conclusion: This study’s significant finding was that asymptomatic CAD is common in SLE patients, even in those thought to be low risk for CAD and in the absence of cardiac symptoms.
Expression of urokinase plasminogen activator receptor on monocytes and granulocytes is modulated by cardiac surgery
Authors: Krejsek Jan , Kolackova Martina , Kunes Pavel , Jankovicova Karolina , Mandak Jiri , Andrys Ctirad 
Published: November 2010

Aims: Coronary artery bypass grafting (CABG) is linked to the induction of the blood coagulation/fibrinolysis cascade, which is an integral component of inflammation induced by cardiac surgery. We followed the modulation of urokinase plasminogen activator receptor uPAR (CD87) separately for monocytes and granulocytes in blood of cardiac surgery patients. Methods: Expression of uPAR, analyzed as Median Fluorescence Intensity (MFI), on blood monocytes and granulocytes was determined by flow cytometry. Changes in uPAR expression in patients undergoing CABG using standard cardiopulmonary bypass (“on-pump”) were compared to the changes in uPAR expression in patients undergoing CABG using mini-invasive cardiopulmonary bypass (“mini on-pump”). Results: In “on-pump” patients, the median of uPAR expression on granulocytes before surgery was 18.1 (InterQuartile Range (IQR): 15.6-20.4). uPAR expression was significantly decreased after surgery (p<0.001), on the first postoperative day (p<0.001), and on the third postoperative day (p<0.05). In “mini on-pump” patients, the median of uPAR expression on granulocytes before surgery was 15.2 (IRQ: 13.8-19.4). The significantly decreased uPAR expression was found only at the end of surgery (p<0.05). The similar pattern of uPAR expression was also found for monocytes. The preoperative level in “on-pump” patients was 23.3 (IRQ: 18.9-30.2). There was significantly decreased uPAR expression at the end of surgery (p<0.01) and at the first postoperative day (p<0.05). In “mini on-pump” patients, the preoperative uPAR expression was 16.9 (IQR: 14.5-20.2). Expression of uPAR was significantly decreased only after surgery (p<0.05). When comparing “onpump” patients to “mini on-pump” patients, no significant differences in the expression of uPAR were found. Conclusion: uPAR expression on granulocytes and monocytes is significantly modulated by cardiac surgery.
Habitual physical activity can be increased in people with cerebral palsy: a systematic review
Authors: Bania Theofani , Dodd Karen J , Taylor Nicholas 
Published: November 2010

Objective: To determine if habitual physical activity could be increased in people with cerebral palsy. Data sources: We searched electronic databases until February 2010 using key words related to concepts of cerebral palsy and physical activity. This search was supplemented with citation tracking. Methods: Studies had to include participants with cerebral palsy who have habitual physical activity measured over at least one day after a therapy intervention. Two reviewers independently assessed study quality with the PEDro scale (quantitative studies) and Critical Appraisal Checklist for Qualitative Research (qualitative studies). For quantitative studies standardized mean differences were calculated and meta-analysis conducted. Qualitative data were synthesized thematically. Results: Three randomized controlled trials (96 participants) and two qualitative studies (21 participants) were reviewed. Four studies evaluated exercise programmes, and one study an online educational and support programme. Meta-analysis showed that exercise programmes could increase habitual physical activity (δ = 1.0; 95% confidence interval (CI) 0.28 to 1.72). This result was reinforced by reports of increased daily activity in two qualitative studies. The online programme increased weekly minutes of moderate to vigorous physical activity (d = 0.81; 95% CI 0.17 to 1.45), and weekly step counts (d = 0.62; 95% CI 0.0 to 1.25). Positive effects were not maintained after programmes stopped. There was insufficient evidence to determine if demographic factors or programme characteristics, such as intensity and setting, were associated with outcomes. Conclusion: Preliminary evidence suggests that exercise programmes and online support programmes can increase habitual physical activity in people with cerebral palsy, but effects are not maintained when programmes stop.
The effects of verbal instructions on gait in people with Parkinson’s disease: a systematic review of randomized and non-randomized trials
Authors: Fok Pamela , Farrell Michael , McMeeken Joan , Kuo Yi-Liang 
Published: November 2010

Objective: To collate and appraise empirical evidence relating to the effects of verbal instructions (verbal commands given by another person) on stride length, gait velocity and stride variability in people with Parkinson’s disease. Data sources: Cinahl, Cochrane, Embase, Medline, PEDro, PsycINFO and Web of Science. Review methods: Independent reviewers extracted data from eligible studies and assessed methodological quality. The level of evidence was determined by best evidence synthesis based upon the experimental design, methodological quality and statistical findings of individual studies. Results: One randomized controlled study and 12 non-controlled studies fulfilled the selection criteria and involved 149 participants. Five types of verbal instructions were examined which included ‘take big steps’, ‘walk fast’, ‘swing arms when walking’, ‘count rhythm when walking’ and ‘walk fast with big steps’. Best evidence synthesis found indicative evidence in support of the use of the instruction to take big steps in walking training for stride length improvement in people with mild to moderate Parkinson’s disease who are without cognitive impairment. There was insufficient evidence in support of effects on gait velocity and stride variability. There was also insufficient evidence in support of effects of other instructions on any of the gait variables. Conclusion: The empirical evidence in support of the benefits from verbal instructions is weak. The evidence is limited to short-term stride length improvement from the use of the instruction to take big steps in walking training.
CD34+ progenitor cells mobilized by natalizumab are not a relevant reservoir for JC virus
Authors: Warnke Clemens , Smolianov Vsevolod , Dehmel Thomas , Andrée Marcel , Hengel Hartmut , Zohren Fabian , Arendt Gabriele , Wiendl Heinz , Haas Rainer , Hartung Hans-Peter , Adams Ortwin , Kieseier Bernd C 
Published: November 2010

Background: Progressive multifocal leukoencephalopathy (PML) is associated with natalizumab treatment in patients with multiple sclerosis (MS). It has been hypothesized that natalizumab mobilizes JC virus (JCV)-infected haematopoietic progenitor cells mediating viraemia and subsequently this disease. Objective: The objective of this study was to investigate peripheral haematopoietic progenitor cells for evidence of JCV DNA in MS patients treated with natalizumab. Methods: We assessed JCV and cytomegalovirus (CMV) DNA in magnetically separated CD34+ haematopoietic progenitor cells, peripheral blood mononuclear cells and plasma of 67 natalizumab-treated patients with MS and six PML patients. Results: Viral DNA was not detectable in CD34+ haematopoietic progenitor or peripheral blood mononuclear cells from any sample. Two plasma samples from patients with MS while undergoing natalizumab treatment were JCV-positive. In one case clinically manifest PML developed 8 months thereafter. Conclusions: Our findings do not support the hypothesis that natalizumab mobilizes JC virus-infected CD34+ cells from the bone marrow mediating JC viraemia. Notably, JC viraemia was detected in one patient with MS prior to developing clinical PML. This warrants further study.
Primary progressive versus relapsing-onset multiple sclerosis: presence and prognostic value of cerebrospinal fluid oligoclonal IgM
Authors: Sola Patrizia , Mandrioli Jessica , Simone Anna M , Ferraro Diana , Bedin Roberta , Annecca Rosanna , Venneri Maria G , Nichelli Paolo F , Merelli Elisa 
Published: November 2010

Background: There is increasing evidence on cerebrospinal fluid (CSF) oligoclonal IgM (OCIgM) predicting a more aggressive disease course in relapsing–remitting Multiple Sclerosis (MS), while there is a scarcity of data for primary progressive MS (PPMS). Objective: Our aim was to investigate the presence and possible prognostic value of CSF OCIgM in a group of PPMS and in a group of relapsing-onset MS patients. The possible prognostic role of other clinical and biological factors was also evaluated. Methods: We calculated the impact of single clinical and biological factors, including CSF OCIgM at onset, on the probability of reaching an Expanded Disability Status Scale of 3 and 4 in 45 PPMS and 104 relapsing-onset MS patients. Results: CSF OCIgM were found in only 13% of PPMS patients and did not influence the time taken to reach an Expanded Disability Status Scale of 3 and 4. Conversely, they were present in 46% of relapsing-onset MS patients and increased the risk of reaching an Expanded Disability Status Scale of 4. Clinical factors with a negative prognostic value in PPMS were age at onset <30 years and onset with pyramidal symptoms, while onset with sensory symptoms in relapsing-onset MS predicted a more favourable course. Conclusion: This study confirms that, in relapsing-onset MS patients, the presence of CSF OCIgM at onset predicts a worse disease course. In the cohort of PPMS patients, however, CSF OCIgM were rare, suggesting that heterogeneous pathogenetic mechanisms may be involved in the different MS forms.