bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential risk assessment: a model for quality evaluation in fluoroscopy-guided interventional procedures
Authors: Oliveira Marcus , Navarro Marcus , Costa Eliana , Kremer Djeimis , Pinheiro Regina , Freitas Vanessa , Modesto Igor , Macedo Erik , Ferreira Jeovana , Andrade Daniele , Damasceno Lauro , Joseneas Enoque 
Published: April 2024

Abstract
This study presented a model applied for potential risk assessment in an interventional radiology setting. The model of potential risk assessment (MARP) consisted of the creation of a scale of indicators ranging from 0 to 5. The radiation levels were categorized according to gender, kind of procedure, value of kerma air product (Pka), and accumulated radiation dose (mGy). The MARP model was applied in 121 institutions over 8 y. A total of 201 656 patient radiation doses (Dose-area product and accumulated kerma) data were launched into the system over time, with an average of 22 406 doses per year. In the context of the workers (cardiologists, radiographers, and nurses) monitored during the MARP application, 8007 cases (with an average of 890 per year) of occupational radiation doses were recorded. This study showed a strategy for quality evaluation in fluoroscopy using a model with a compulsory information system for monitoring safety.
Measurement of Adverse Events in Studies of Digital Health Interventions for Psychosis: Guidance and Recommendations Based on a Literature Search and Framework Analysis of Standard Operating Procedures
Authors: Eisner Emily , Richardson Cara , Thomas Neil , Rus-Calafell Mar , Syrett Suzy , Firth Joseph , Gumley Andrew , Hardy Amy , Allan Stephanie , Kabir Thomas , Ward Thomas , Priyam Aansha , Bucci Sandra ,   the iCharts network, Myin-Germeys Inez , Reininghaus Ulrich , Chaudhry Imran , Alvarez Mario , Gleeson John , Granholm Eric , Schwannauer Matthias , Garety Philippa , Torous John , Cella Matteo , Bell Imogen , van Aubel Evelyne , Kiran Tayyeba , Schick Anita , Zhang Xiaolong 
Published: April 2024

Abstract

Background
Given the rapid expansion of research into digital health interventions (DHIs) for severe mental illness (SMI; eg, schizophrenia and other psychosis diagnoses), there is an emergent need for clear safety measures. Currently, measurement and reporting of adverse events (AEs) are inconsistent across studies. Therefore, an international network, iCharts, was assembled to systematically identify and refine a set of standard operating procedures (SOPs) for AE reporting in DHI studies for SMI.

Design
The iCharts network comprised experts on DHIs for SMI from seven countries (United Kingdom, Belgium, Germany, Pakistan, Australia, United States, and China) and various professional backgrounds. Following a literature search, SOPs of AEs were obtained from authors of relevant studies, and from grey literature.

Results
A thorough framework analysis of SOPs (n = 32) identified commonalities for best practice for certain domains, along with significant gaps in others; particularly around the classification of AEs during trials, and the provision of training/supervision for research staff in measuring and reporting AEs. Several areas which could lead to the observed inconsistencies in AE reporting and handling were also identified.

Conclusions
The iCharts network developed best-practice guidelines and a practical resource for AE monitoring in DHI studies for psychosis, based on a systematic process which identified common features and evidence gaps. This work contributes to international efforts to standardize AE measurement and reporting in this emerging field, ensuring that safety aspects of DHIs for SMI are well-studied across the translational pathway, with monitoring systems set-up from the outset to support safe implementation in healthcare systems.
Development and Validation of the Curriculum Evaluation Tool–Diversity, Equity, and Inclusion: A Tool for Evaluating Diversity, Equity, and Inclusion in Nursing Curricula
Authors: McKinley Yoder Claire , Mayer Kala , Rothacker-Peyton Sally , Williamson Gordon , McKown Arden , Ou Chivon 
Published: April 2024

Abstract
Professional organizations and experts are calling for nursing education to be more diverse. The nursing education curriculum has been identified as one structural barrier to a diverse workforce. This article describes the development and initial validation of the CET-DEI, a curriculum evaluation tool for diversity, equity, and inclusion in nursing education. The results of a survey to establish validity are presented. Continued development of this tool shows promise for future integration in curriculum evaluation, an important first step in dismantling barriers to diversity in nursing education and the workforce.
Foramen Facet Spinal Classification for Ossification of the Posterior Longitudinal Ligament on Computed Tomography
Authors: Wang Shunmin , Yang Yong , Han Dan , Guo Yongfei , Shi Jiangang , Wang Yuan , Sun Jingchuan 
Published: April 2024

Study Design:
Retrospective study.

Objective:
To develop and validate computed tomography (CT)–based classification schemes to eliminate ambiguity as much as possible and evaluate the adequacy and clinical value of its classification.

Background:
There is no objective criteria for laminoplasty of more than one million Chinese patients with ossification of the posterior longitudinal ligament (OPLL) every year. CT imaging can accurately show the location, size, and shape of ossification, it is very important to propose a recognized simple classification of ossifications.

Patients and Methods:
From 2016 to 2018, 100 patients with “moderate to severe” OPLL on CT were performed according to the following criteria. This study simply classifies the grade of the ossification as 1-2-3, the zone is A-B by the foramen facet spinal canal classification, and the interexaminer reliability is 96%. A prospective series of 60 patients for laminoplasty was performed between 2018 and 2019, and this classification scheme was verified according to the new standard. All patients with size 1 were selectively excluded from consideration for surgery. The Japanese Orthopedic Association scores from both series are superior to most published results for patients with OPLL.

Results:
The first and second series reported good to excellent results of 89% and 93.3%, respectively, and 80% and 85% for 24 months. The difference in the incidence of C5 paralysis and axial pain was statistically significant among the different zones, and most of them recovered within 6 months. The most common size and location types are 2-AB, 3-AB, and 2A. The most severe type is 3-AB.

Conclusions:
The foramen facet spinal classification of OPLL is a simple and reliable method for objectively evaluating the ossification of patients with OPLL based on CT research.

Level of Evidence:
Level III.
The effects of anaesthesia and analgesia on short- and long-term outcomes following colorectal cancer surgery
Authors: Bell Max , Buggy Donal J. , Brattström Daniel , Buchli Christian , Debouche Sophie , Granath Fredrik , Riedel Bernard , Gupta Anil 
Published: April 2024

BACKGROUND
Colorectal cancer (CRC) is the second most frequent cause of global cancer mortality. Most patients with CRC require surgical tumour resection, with certain stages of CRC (Stage II/III) also requiring postoperative chemotherapy. The timing of postoperative chemotherapy is largely determined by postoperative recovery. Delayed return to intended oncologic therapy (RIOT) by >8 weeks results in worse oncologic outcomes. RIOT is thus an important surrogate marker of outcome for patients with stage II/III CRC. We will test the hypothesis that anaesthetic technique during CRC resection surgery may affect RIOT.

OBJECTIVE
To test the association between anaesthetic and analgesic technique during CRC surgery and RIOT. To document Short-term Secondary outcomes including individual postoperative complications and a composite of all postoperative complications, the Comprehensive Complications Index (CCI) and to measure the time to recurrence (TTR) of cancer at 3 years.

DESIGN
This is a prospective, international, multicentre, observational cohort study.

SETTING
Global healthcare setting, with >140 centres in >30 nations.

PATIENTS
Inclusion criteria: All patients age >18 years, ASA I–III, with CRC stage I–III scheduled for elective CRC surgery (open or minimally invasive).
Exclusion criteria: Uncontrolled renal or liver disease, restrictive (limiting mobility) heart failure or ischemic heart disease (ASA IV–V). Speech, language, or cognitive difficulties precluding signing informed consent to participate and Stage IV CRC.

PRIMARY OUTCOME MEASURES
Short -term: The duration from day of surgery to RIOT among patients expected to receive postoperative chemotherapy. Long-term: incidence of recurrence and time to recurrence (TTR) at 3 years after primary curative surgery

SECONDARY OUTCOMES
Postoperative complications within 30 days of surgery, length of hospital stay, Days at Home at 30 and 90 days (DAH-30, DAH-90) after surgery, and adverse events related to oncological treatment. We will also assess the burden of preoperative modifiable comorbid disease in patients. Exploratory endpoints will assess practice variation (including incidence of RIOT by demographic e.g. gender of patient, type of institution, country).

RESULTS
N/A.

CONCLUSIONS
N/A.

TRIAL REGISTRATION
The Effects of aNesthesia in COloREctal cancer outcome study: ENCORE, ClinicalTrials.gov Identifier: NCT04493905.
RANDOMIZED TRIAL COMPARING MICROSERRATED VERSUS CONVENTIONAL INTERNAL LIMITING MEMBRANE FORCEPS FOR INTERNAL LIMITING MEMBRANE PEELING
Authors: Starr Matthew R. , Hinkle John C. , Patel Luv G. , Ammar Michael J. , Soares Rebecca R. , Patel Samir N. , Cohen Michael N. , Hsu Jason , Yonekawa Yoshihiro , Ho Allen C. , Regillo Carl D. , Gupta Omesh P. 
Published: April 2024

Purpose:
To evaluate anatomic outcomes and surgeon response following the use of microserrated (Sharkskin, Alcon, Forth Worth, TX) internal limiting membrane (ILM) forceps compared with conventional (Grieshaber; Alcon) ILM forceps for peeling of the ILM.

Methods:
Patients were prospectively assigned in a 1:1 randomized fashion to undergo ILM peeling using microserrated forceps or conventional forceps. Rates of retinal hemorrhages, deep retinal grasps, ILM regrasping, time to ILM removal, and surgeon questionnaire comparing the use of microserrated and conventional ILM forceps were analyzed.

Results:
A total of 90 eyes of 90 patients were included in this study. The mean number of deep retinal grasps was higher in the conventional forceps group (1.51 ± 1.70 vs. 0.33 ± 0.56, respectively [P < 0.0001]). The mean number of failed ILM grasps was higher with conventional forceps (6.62 ± 3.51 vs. 5.18 ± 2.06 [P = 0.019]). Microserrated forceps provided more comfortability (lower number) in initiating the ILM flap (2.16 ± 0.85 vs. 1.56 ± 0.76, P < 0.001), comfortability in regrasping the ILM flap (2.51 ± 1.01 vs. 1.98 ± 0.89, P = 0.01), and comfortability in completing the ILM flap (2.42 ± 1.03 vs. 1.84 ± 1.02, P = 0.01).

Conclusion:
Surgeons utilizing the microserrated forceps experienced fewer deep retina grasps and fewer failed ILM grasps compared with conventional ILM forceps. The microserrated forceps was also a more favorable experience subjectively among the surgeons.
LONGITUDINAL CHANGE OF RETINAL LAYER THICKNESS IN COGNITIVELY NORMAL ELDERLY SUBJECTS
Authors: Kim Hyeong Min , Han Ji Won , Kim Ki Woong , Woo Se Joon 
Published: April 2024

Purpose:
To identify longitudinal retinal layer thickness changes in normal eyes of cognitively healthy elderly people.

Methods:
Post hoc analysis was performed on 57 cognitively healthy elderly participants from the population-based Korean Longitudinal Study on Health and Aging and Korean Longitudinal Study on Cognitive Aging and Dementia cohort studies who underwent baseline and final optical coherence tomography scans. The peripapillary retinal nerve fiber layer, subfoveal choroid, and average retinal layer thickness at four quadrant (nasal, temporal, superior, and inferior) points 1 mm, 2 mm, and 3 mm from the center of the fovea were measured.

Results:
The mean age of subjects was 75.1 years and the mean follow-up period was 55.9 months. Among the analyzed retinal layers, both the ganglion cell–inner plexiform layer and the outer nuclear layer at all 1 mm, 2 mm, and 3 mm points showed a statistically significant decrease in thickness at the final visit compared with baseline. The annual decrease rates were −1.2 µm/year at 1 mm (total −6.6%), −1.3 µm/year at 2 mm (total −8.4%), and −1.1 µm/year at 3 mm (total −9.7%) for ganglion cell–inner plexiform layer and −0.6 µm/year at 1 mm (total −4.2%), −0.5 µm/year at 2 mm (total −3.9%), and −0.4 µm/year at 3 mm (total −4.1%) for outer nuclear layer.

Conclusion:
Aging plays a significant role in the reduction of ganglion cell–inner plexiform layer and outer nuclear layer thicknesses in cognitively healthy elderly individuals.
“Treat and Extend” amphotericin B in post-op DMEK fungal endophthalmitis
Authors: Jain Sparsh , Godiwalla Roxana , Moss Hart 
Published: April 2024

Purpose:
The purpose of this study was to describe a case of post DMEK-fungal endophthalmitis treated with “treat and extend” amphotericin B, a method not fully described in the literature.

Methods:
We conducted an extensive retrospective chart review to create this case report.

Results:
An 85-year-old female with a history of Descemet membrane endothelial keratoplasty (DMEK) and positive yeast growth in the donor tissue presented with clinical signs of endophthalmitis. The culture samples were positive for Candida glabrata, indicating fungal endophthalmitis. Amphotericin B was administered because of its strain’s resistance to azole-like medications. The patient was closely followed every month, then two months, then every ten weeks with persistence of infection with intermittent flare-ups and continues to receive amphotericin B to temporarily reduce ocular symptoms.

Conclusions:
“Treat and extend” with amphotericin B is an alternative method of care for post-DMEK fungal endophthalmitis with the goal of temporary resolution of symptoms and maintenance of vision.
A CASE REPORT OF TEMPORAL MACULAR THINNING ASSOCIATED WITH ALPORT SYNDROME
Authors: Bernstein Paul S. 
Published: April 2024

Purpose:
The objective of this study was to report a case of severe temporal macular thinning in a patient with Alport syndrome. Bilateral temporal thinning is rarely associated with any other systemic conditions, so it is important that ophthalmologists be aware of the significance of this finding and refer for further internal medicine evaluation appropriately.

Methods:
Clinical examination and multimodal imaging are provided from a clinic visit one month after inpatient treatment for a hypertensive crisis associated with renal failure.

Results:
The 19-year-old patient had resolving hypertensive retinopathy. High-resolution optical coherence tomography confirmed that he had temporal thinning indices consistent with his underlying clinical diagnosis of Alport syndrome.

Conclusion:
This case report emphasizes the important role of optical coherence tomography as a commonly available noninvasive retinal imaging modality that can readily demonstrate the temporal macular thinning that is characteristic of Alport syndrome and just a few other conditions. Optical coherence tomography can be an attractive alternative to the much more invasive renal biopsy testing for Alport syndrome when genetic testing is ambiguous or when renal biopsy is considered too risky for the patient.
Determining the Optimal Length of Clinical Education Experiences: Surveying Doctor of Physical Therapy Academic and Clinical Faculty
Authors: Wolden Mitch , Flom-Meland Cindy , Gusman Lori N. , Drevyn Elsa , McCallum Christine 
Published: April 2024

Introduction/Review of Literature.
There is wide variability in the length of full-time clinical education experiences (CEEs) among Doctor of Physical Therapy (DPT) programs. We investigated academic and clinical faculty perspectives on the optimal length and level of agreement on the length, timing, and offering of full-time CEEs.

Subjects'
A survey assessing perspectives on the optimal length and level of agreement for the length, timing, and offering of full-time CEEs was completed by 100 academic and 240 clinical faculty.

Methods'
Differences between academic and clinical faculty responses on the optimal length and level of agreement were assessed with a 2-sample test of proportions and 2-sample t-test.

Results.
Participants believed that the length of full-time CEEs (in weeks) should be single CEE 10.6 (SD 2.3); first CEE 7.8 (SD 2.1); terminal CEE 12.5 (SD 5.4); integrated CEE 9.6 (SD 1.9); and total CEEs 37.2 (SD 6.9). There were significant differences (MD = −3.0; 95% confidence interval [CI] −4.6 to −1.6) between academic and clinical faculty perspectives for the total length of CEEs. No significant differences between academic and clinical faculty perspectives for the length of single, first, terminal, or integrated CEEs. There were significant differences between academic and clinical faculty perspectives for the optimal length of inpatient (MD = 1.1; 95% CI 0.6–1.6) and specialty (MD = 0.8; 95% CI 0.2–1.3) settings. There were significant differences between academic and clinical faculty level of agreement for 8 of 15 items.

Discussion and Conclusion.
There was consistency between academic and clinical faculty regarding the perceived optimal length of full-time CEEs. Academic and clinical faculty perspectives for the optimal length of terminal full-time CEEs (12.5 weeks) were different than those for the national average (21.8 weeks) length of terminal full-time CEEs. Our study provides evidence to support DPT programs' clinical education curriculum decisions regarding the length of full-time CEEs to optimize students learning and maturation.
2023 Pauline Cerasoli Lecture: It Takes a Village to Raise a Profession
Authors: Applebaum Donna L. 
Published: April 2024

Background and Purpose.Personal and profession-related factors affect graduate transition to practice. Social supports and a sense of belonging are recognized as critical factors affecting success. The need for a professional to postprofessional continuum of learning has been identified. Development of a process to effectively move learners through this continuum are affected by conflicts such as economic issues, varied educational and practice philosophies, and capacity demands for clinical sites and instructors. The purpose of this article was to discuss professional formation as an individual experience that needs environmental support. If we look to the intrinsic needs of the individual to develop effective systems, both individuals and the profession will thrive.Position and Rationale.The changing demographics of students and factors affecting health care and education offer compelling reasons to reconsider the pathway for early professional development. Education and practice must collaborate to cocreate the foundation for professional formation. Basic needs such as economic security and social belonging must be met to create optimal conditions for learning and growth.Discussion and Conclusion.The profession has not adopted an intentional pathway for new graduates to meet foundational practice needs. Some new graduates seek residencies, but residencies are focused on specialization and supply does not meet the demand. Strategies to promote success of early career professionals include a professional to postprofessional curriculum with intentional mentorship, changes in the regulatory environment, and formation of effective partnerships to support education and practice.
Bronchoscopic treatment of early-stage peripheral lung cancer
Authors: Villalba Aristides J. Armas , Ost David E. 
Published: April 2024

Purpose of review
This review article focuses on bronchoscopic treatment of early-stage peripheral lung cancer.

Recent findings
Bronchoscopic treatment modalities have garnered considerable attention for early-stage lung cancer. Studies using photodynamic therapy, thermal vapor ablation, laser ablation, cryoablation, and intra-tumoral injection have recently been published. However, the evidence supporting these approaches largely derives from single-arm studies with small sample sizes. Based on the IDEAL-D framework, no technology has progressed passed the idea phase (1). The main weakness of these technologies to date is lack of evidence suggesting they can achieve local control. Presently, no bronchoscopic intervention for lung cancer has sufficient data to warrant its use as part of the standard of care.

Summary
Despite notable progress, current technologies remain suboptimal, and there is insufficient evidence to support their use outside of a research setting.
S100A6 could not promote the differentiation of Calu-6 lung cancer cell line
Authors: Li Jie , Wang Ting , Dang Dan 
Published: April 2024

Background:
Our previous study demonstrated that S100 calcium binding protein A6 (S100A6) impairs tumorigenesis by Calu-6 lung cancer cells, as well as inhibit their growth. However, the role that S100A6 plays in tumor cell differentiation has not been previously explored. This study aimed to confirm the effect of S100A6 on the direction of differentiation in the human lung cancer cell linem Calu-6m based on our previous published research.

Materials and methods:
A S100A6-overexpressing lentiviral vector was successfully constructed in our previous study. Nude mouse tumorigenicity was then applied successfully, and 15 mice were divided into three groups (Calu-6, Calu-6/neo, Calu-6/S100A6). After 5 weeks, we detected lung cancer markers with immunohistochemistry in mice tumor tissues, including the adenocarcinoma markers, TTF-1 and NapsinA, the squamous cell carcinoma markers, P40, CK5/6 and P63, and the small cell lung cancer markers CD56, Syn, CgA, TTF-1, CK, and Ki-67. Differences among the three groups were statistically compared.

Results:
All the above-mentioned markers were positive in the tumor tissues of all three groups, and there were no significant differences.

Conclusion:
S100A6 cannot promote differentiation of the undifferentiated human lung cancer cell line, Calu-6, into adenocarcinoma, squamous, or small cell carcinoma cell lines.
The Impact of Modified Body Mass Index on Clinical Prognosis in the Elderly With Acute Ischemic Stroke
Authors: Li Feng , Zhao Yan , Wang Jing , Chen Jiu , Wang Maoxue , Hu Wenxia , Zhang Bing 
Published: April 2024

Objectives:
The modified body mass index (mBMI) combines the body mass index and serum albumin, accurately reflecting the nutritional status. It remains uncertain whether modified body mass index influences neurological function and clinical prognosis in elderly patients with acute ischemic stroke.

Methods:
We divided the cohort into quartiles of mBMI (1 to 4). The primary outcome was analyzed using the percentage of patients with a 90-day modified Rankin scale (mRS) score of 0 to 1. There were 7 secondary outcomes, including the disability level at 90 days and the National Institute of Health Stroke Scale (NIHSS) score at 14 and 90 days.

Results:
mBMI was negatively associated with clinical prognosis at 90-day mRS score in the primary outcome (β=−0.167; 95% CI −0.311 to 0.023, P=0.023). Moreover, mBMI1 (<896.72) and primary outcomes (β=0.438; 95% CI: −0.018 to 0.894) were positively correlated with higher mBMI. Moreover, the number and percentage of patients completing all the duties and activities are also higher. Age-adjusted Charlson comorbidity index (aCCI) and posterior circulation lesion were positively associated with the clinical prognosis 90-day mRS score in the primary outcome (β=2.218; 95% CI: 1.144-4.300, β=2.771; 95% CI: 1.700-4.516). However, BMI and serum albumin were not associated the with clinical prognosis primary outcome. BMI negatively correlates with secondary outcomes (NIHSS at discharge, β=−0.023; 95% CI: −0.102 to 0.057).

Conclusions:
Our study revealed that mBMI and not BMI could be a better primary outcome predictor in the elderly with acute ischemic stroke, and lower mBMI showed a worse prognosis.