bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Integrase Strand Transfer Inhibitor-Based Antiretroviral Therapy With Blood Pressure and Sustained Hypertension in People With Human Immunodeficiency Virus
Authors: Siddiqui Mohammed , Burkholder Greer A , Judd Eric , Wang Zhixin , Colantonio Lisandro D , Ghazi Lama , Shimbo Daichi , Willig Amanda L , Overton Edgar T , Oparil Suzanne , Levitan Emily B , Heath Sonya L , Muntner Paul 
Published: June 2024

Abstract

BACKGROUND
Integrase strand transfer inhibitors (INSTIs) are a commonly used antiretroviral therapy (ART) class in people with human immunodeficiency virus (HIV) and associated with weight gain. We studied the association of INSTI-based ART with systolic and diastolic blood pressure (SBP and DBP).

METHODS
We recruited 50 people taking INSTI-based ART and 40 people taking non-INSTI-based ART with HIV and hypertension from the University of Alabama at Birmingham HIV clinic. Office BP was measured unattended using an automated (AOBP) device. Awake, asleep, and 24-hour BP were measured through ambulatory BP monitoring. Among participants with SBP ≥130 mm Hg or DBP ≥80 mm Hg on AOBP, sustained hypertension was defined as awake SBP ≥130 mm Hg or DBP ≥80 mm Hg.

RESULTS
Mean SBP and DBP were higher among participants taking INSTI- vs. non-INSTI-based ART (AOBP-SBP/DBP: 144.7/83.8 vs. 135.3/79.3 mm Hg; awake-SBP/DBP: 143.2/80.9 vs. 133.4/76.3 mm Hg; asleep-SBP/DBP: 133.3/72.9 vs. 120.3/65.4 mm Hg; 24-hour-SBP/DBP: 140.4/78.7 vs. 130.0/73.7 mm Hg). After multivariable adjustment, AOBP, awake, asleep, and 24-hour SBP were 12.5 (95% confidence interval [CI] 5.0–20.1), 9.8 (95% CI 3.6–16.0), 10.4 (95% CI 2.0–18.9), and 9.8 (95% CI 4.2–15.4) mm Hg higher among those taking INSTI- vs. non-INSTI-based ART, respectively. AOBP, awake, asleep, and 24-hour DBP were 7.5 (95% CI 0.3–14.6), 6.1 (95% CI 0.3–11.8), 7.5 (95% CI 1.4–13.6), and 6.1 (95% CI 0.9–11.3) mm Hg higher among those taking INSTI- vs. non-INSTI-based ART after multivariable adjustment. All participants had SBP ≥130 mm Hg or DBP ≥80 mm Hg on AOBP and 97.9% and 65.7% of participants taking INSTI- and non-INSTI-based ART had sustained hypertension, respectively.

CONCLUSIONS
INSTI-based ART was associated with higher SBP and DBP than non-INSTI-based ART.
The effect of multiple types of workplace violence on burnout risk, sleep quality, and leaving intention among nurses
Authors: Pien Li-Chung , Cheng Yawen , Lee Fang-Chun , Cheng Wan-Ju 
Published: June 2024

AbstractObjectiveThe aim of our study is to explore the associations between multiple types of workplace violence (WPV) and burnout risk, sleep problems, and leaving intention among nurses.MethodsThis cross-sectional survey recruited 1,742 nurses, and data on WPV experiences were collected through self-administered questionnaires. Work conditions, burnout risk scales, sleep quality, and leaving intentions were also evaluated. Multivariate logistic regression analyses were performed to examine the associations of WPV with burnout risk, sleep quality, and leaving intentions, adjusting for demographic characteristics and work conditions.ResultsThe study found that 66.7% of nurses reported experience of WPV, with 26.9% experiencing both physical and nonphysical forms. Those who experienced multiple types of WPV reported worse work conditions, higher burnout risk, poorer sleep quality, and a stronger leaving intention compared to those without such experiences. Adjusting for working conditions, logistic regression analysis showed that nurses who experienced multiple types of WPV had 2.12-fold higher odds of high personal burnout risk, 2.36-fold higher odds of high client-related burnout risk, 1.95-fold higher odds of poor sleep quality, and 1.80-fold higher odds of high leaving intention, compared to those without WPV experiences.ConclusionsStrategies by hospital managers and policymakers to monitor and reduce workplace violence are vital for sustaining nurses’ mental health, well-being, and preventing early attrition from the profession.
Morphological profiling for drug discovery in the era of deep learning
Authors: Tang Qiaosi , Ratnayake Ranjala , Seabra Gustavo , Jiang Zhe , Fang Ruogu , Cui Lina , Ding Yousong , Kahveci Tamer , Bian Jiang , Li Chenglong , Luesch Hendrik , Li Yanjun 
Published: June 2024

Abstract
Morphological profiling is a valuable tool in phenotypic drug discovery. The advent of high-throughput automated imaging has enabled the capturing of a wide range of morphological features of cells or organisms in response to perturbations at the single-cell resolution. Concurrently, significant advances in machine learning and deep learning, especially in computer vision, have led to substantial improvements in analyzing large-scale high-content images at high throughput. These efforts have facilitated understanding of compound mechanism of action, drug repurposing, characterization of cell morphodynamics under perturbation, and ultimately contributing to the development of novel therapeutics. In this review, we provide a comprehensive overview of the recent advances in the field of morphological profiling. We summarize the image profiling analysis workflow, survey a broad spectrum of analysis strategies encompassing feature engineering– and deep learning–based approaches, and introduce publicly available benchmark datasets. We place a particular emphasis on the application of deep learning in this pipeline, covering cell segmentation, image representation learning, and multimodal learning. Additionally, we illuminate the application of morphological profiling in phenotypic drug discovery and highlight potential challenges and opportunities in this field.
FastBiCmrMLM: a fast and powerful compressed variance component mixed logistic model for big genomic case-control genome-wide association study
Authors: Wang Jing-Tian , Chang Xiao-Yu , Zhao Qiong , Zhang Yuan-Ming 
Published: June 2024

Abstract
Large sample datasets have been regarded as the primary basis for innovative discoveries and the solution to missing heritability in genome-wide association studies. However, their computational complexity cannot consider all comprehensive effects and all polygenic backgrounds, which reduces the effectiveness of large datasets. To address these challenges, we included all effects and polygenic backgrounds in a mixed logistic model for binary traits and compressed four variance components into two. The compressed model combined three computational algorithms to develop an innovative method, called FastBiCmrMLM, for large data analysis. These algorithms were tailored to sample size, computational speed, and reduced memory requirements. To mine additional genes, linkage disequilibrium markers were replaced by bin-based haplotypes, which are analyzed by FastBiCmrMLM, named FastBiCmrMLM-Hap. Simulation studies highlighted the superiority of FastBiCmrMLM over GMMAT, SAIGE and fastGWA-GLMM in identifying dominant, small α (allele substitution effect), and rare variants. In the UK Biobank-scale dataset, we demonstrated that FastBiCmrMLM could detect variants as small as 0.03% and with α ≈ 0. In re-analyses of seven diseases in the WTCCC datasets, 29 candidate genes, with both functional and TWAS evidence, around 36 variants identified only by the new methods, strongly validated the new methods. These methods offer a new way to decipher the genetic architecture of binary traits and address the challenges outlined above.
Using Scammers’ Data to Estimate the Impact and Importance of Preventing Repeat Mail Fraud Victimization
Authors: Langton Lynn , DeLiema Marguerite , Brannock Daniel , Preble Edward 
Published: June 2024

Abstract
This study examines the frequency and cost of repeat mail fraud victimization in the United States using longitudinal data from a unique source: records from four scam enterprises that operated over a nearly 20-year period. Findings show that most mail fraud victims experience repeat victimization and a small percentage account for most of the losses. Sixty-two per cent of victims responded to more than one mail solicitation. Chronic victims, who responded more than 20 times, comprised 8.8 per cent of the sample and lost $1,771, on average. Findings suggest the need for early intervention to prevent repeat and chronic victimization, thereby reducing the harm for victims. Limitations and implications for future research are discussed.
Deadly Language Games: Theological Reflections on Emerging Reproductive Technologies
Authors: Colgrove Nicholas 
Published: June 2024

AbstractThis issue of Christian Bioethics explores theological, metaphysical, and ethical questions surrounding emerging reproductive technologies. Narratives concerning such technologies are often manipulated via “language games.” Language games involve toying with language to ensure that one’s vision of the good gains or retains political prominence. Such games are common in academic discussions of “artificial womb” technologies. Abortion proponents, for example, are already using language to dehumanize subjects within “artificial wombs.” This is unsurprising. Were relevant subjects considered persons, then abortion access (and other forms of “reproductive autonomy”) might be curtailed. Here, I show that abortion proponents’ language games often depend on dubious metaphysical claims. Second, I argue that Christians should oppose dehumanizing language games, since those games undermine “neighbor-love,” which Christians are commanded to show others. I also highlight how discussions of other technologies—such as medication abortion—are affected by confused (or manipulative) language. Ultimately, the language games I critique aim to preserve and expand the “rights” of the powerful to dehumanize, control, and kill vulnerable human beings. Since neighbor-love commands Christians to provide for “the least of these,” however, Christians must expose these manipulative language games, refute them, and resist the corrupt ideologies from which they flow.
What’s (in) a CBO? Analyzing community representation in the Kenyan aid chain
Authors: Matelski Maaike , Woensdregt Lise 
Published: June 2024

Abstract
Within the field of development research and practice, there is a growing realization that interventions aimed at supporting emancipation struggles in the Global South should prioritize local actors and agendas. Consequently, community-based organizations (CBOs) are increasingly considered vehicles of change. The label ‘community-based’ has become central to the work of non-governmental organizations and donors seeking to connect with ‘grassroots’ populations and is frequently used by groups engaged in self-representation on different levels. In this article, we seek to study various forms of CBOs involved in the aid chain in their own right, rather than as mere recipients of aid. Drawing on comparative empirical case studies involving a queer male sex worker-led organization in Nairobi and a group of CBOs in rural Kenya, we illustrate how, despite uniform approaches in development discourse, these organizations take on completely different forms, functions and practices, which influences their relationships with development actors. We seek to problematize over-simplified depictions of CBOs by showing that these in reality comprise a wide range of groups, from local ad hoc initiatives, to highly professionalized actors operating on the (trans)national level. We therefore argue that CBOs should be understood as comprising a continuum in forms, functions and practices, which influences their power positions within transnational aid chains. We recommend that development actors explore the organizational structures of the local groups they work with, including questions of voice and representation, and take into account individual CBOs’ desired roles within the aid chain.
Food Insecurity at Tuberculosis Treatment Initiation Is Associated With Clinical Outcomes in Rural Haiti: A Prospective Cohort Study
Authors: Richterman Aaron , Saintilien Elie , St-Cyr Medgine , Claudia Gracia Louise , Sauer Sara , Pierre Inobert , Compere Moise , Elnaiem Ahmed , Dumerjuste Dyemy , Ivers Louise C 
Published: June 2024

Abstract

Background
Tuberculosis is a leading cause of death worldwide, and food insecurity is known to negatively influence health outcomes through multiple pathways. Few studies have interrogated the relationship between food insecurity and tuberculosis outcomes, particularly independent of nutrition.

Methods
We conducted a prospective cohort study of adults initiating first-line treatment for clinically suspected or microbiologically confirmed drug-sensitive tuberculosis at a rural referral center in Haiti. We administered a baseline questionnaire, collected clinical data, and analyzed laboratory samples. We used logistic regression models to estimate the relationship between household food insecurity (Household Hunger Scale) and treatment failure or death. We accounted for exclusion of patients lost to follow-up using inverse probability of censoring weighting and adjusted for measured confounders and nutritional status using inverse probability of treatment weighting.

Results
We enrolled 257 participants (37% female) between May 2020 and March 2023 with a median age (interquartile range) of 35 (25–45) years. Of these, 105 (41%) had no hunger in the household, 104 (40%) had moderate hunger in the household, and 48 (19%) had severe hunger in the household. Eleven participants (4%) died, and 6 (3%) had treatment failure. After adjustment, food insecurity was significantly associated with subsequent treatment failure or death (odds ratio 5.78 [95% confidence interval, 1.20–27.8]; P = .03).

Conclusions
Household food insecurity at tuberculosis treatment initiation was significantly associated with death or treatment failure after accounting for loss to follow-up, measured confounders, and nutritional status. In addition to the known importance of undernutrition, our findings indicate that food insecurity independently affects tuberculosis treatment outcomes in Haiti.
Mapping the emergence of the circular economy within the governance paths of shrinking cities and regions: a comparative study of Parkstad Limburg (NL) and Satakunta (FI)
Authors: Marjanović Marjan , Williams Joanna 
Published: June 2024

Abstract
This paper studies the interplay between governance priorities concerning urban shrinkage and the circular economy (CE) agenda in the cases of Parkstad Limburg (NL) and Satakunta (FI), aiming to assess the potential of European circular imaginaries for creating novel development pathways in shrinking cities and regions. The findings reveal that the CE agenda emerges within specific sectors due to various influences, including European institutional frameworks, national policies and local initiatives. Notably, the advocacy of commercial actors plays an instrumental role in advancing the CE concept into policy. However, both regions also demonstrate differences arising from distinct regional characteristics. Satakunta harnesses its manufacturing legacy to pursue economic and demographic growth through an industrial CE. Meanwhile, Parkstad Limburg prioritises circular construction to facilitate spatial restructuring and secure public funding. Therefore, in shrinking contexts, CE operates as a unifying agenda for existing interests, upholding prevailing political priorities rather than opening novel governance avenues.
Highly Sensitive Immunoassay for Long Forms of Cardiac Troponin T Using Upconversion Luminescence
Authors: Salonen Selma M , Tuominen Tuulia J K , Raiko Kirsti I S , Vasankari Tuija , Aalto Rami , Hellman Tapio A , Lahtinen Satu E , Soukka Tero , Airaksinen K E Juhani , Wittfooth Saara T 
Published: June 2024

Abstract

Background
Long cardiac troponin T (cTnT) has been proposed to be a promising and more specific biomarker of acute myocardial infarction (AMI). As it represents a subfraction of circulating cTnT, detection of very low concentrations is a requirement. The aim of this study was to develop a novel, highly sensitive immunoassay for long cTnT.

Methods
A two-step sandwich-type immunoassay for long cTnT was developed, utilizing upconverting nanoparticles (UCNPs) as reporters. The limits of detection and quantitation were determined for the assay. Linearity and matrix effects were evaluated. Performance with clinical samples was assessed with samples from patients with non-ST elevation myocardial infarction (NSTEMI, n = 30) and end-stage renal disease (ESRD, n = 37) and compared to a previously developed time-resolved fluorescence (TRF)-based long cTnT assay and a commercial high-sensitivity cTnT assay.

Results
The novel assay reached a 28-fold lower limit of detection (0.40 ng/L) and 14-fold lower limit of quantitation (1.79 ng/L) than the previously developed TRF long cTnT assay. Li-heparin and EDTA plasma, but not serum, were found to be suitable sample matrixes for the assay. In a receiver operating characteristics curve analysis, the troponin ratio (long/total cTnT) determined with the novel assay showed excellent discrimination between NSTEMI and ESRD with an area under the curve of 0.986 (95% CI, 0.967–1.000).

Conclusions
By utilizing upconversion luminescence technology, we developed a highly sensitive long cTnT assay. This novel assay can be a valuable tool for investigating the full potential of long cTnT as a biomarker for AMI.
ClinicalTrials.gov Registration Number: NCT04465591
Demographic and physiological signals of reproductive events in humpback whales on a southwest pacific breeding ground
Authors: Pallin Logan J , Garrigue Claire , Kellar Nicholas M , Baker C Scott , Bonneville Claire D , Derville Solène , Garland Ellen C , Steel Debbie , Friedlaender Ari S 
Published: June 2024

Abstract
The field of marine mammal conservation has dramatically benefited from the rapid advancement of methods to assess the reproductive physiology of individuals and populations from steroid hormones isolated from minimally invasive skin–blubber biopsy samples. Historically, this vital information was only available from complete anatomical and physiological investigations of samples collected during commercial or indigenous whaling. Humpback whales (Megaptera novaeangliae) are a migratory, cosmopolitan species that reproduce in warm, low-latitude breeding grounds. New Caledonia is seasonally visited by a small breeding sub-stock of humpback whales, forming part of the endangered Oceania subpopulation. To better understand the demographic and seasonal patterns of reproductive physiology in humpback whales, we quantified baseline measurements of reproductive hormones (progesterone—P4, testosterone—T and 17β-estradiol—E2) using an extensive archive of skin–blubber biopsy samples collected from female humpback whales in New Caledonia waters between 2016 and 2019 (n = 194). We observed significant differences in the P4, T and E2 concentrations across different demographic groups of female humpback whales, and we described some of the first evidence of the endocrine patterns of estrous in live free-ranging baleen whales. This study is fundamental in its methodological approach to a wild species that has a global distribution, with seasonally distinct life histories. This information will assist in monitoring, managing and conserving this population as global ecological changes continue to occur unhindered.
The shift to authenticity: a framework for analysis of political truth claims
Authors: Sorensen Lone , Krämer Benjamin 
Published: June 2024

Abstract
It is often claimed that political disinformation is more abundant than ever, that populists are particularly prone to lying, and that we live in an era of post-truth or epistemic relativism. Contrary to these views, we interpret this historical trend as a shift from objective to authentic forms of political truth claims. We develop a diagnostic framework that captures different types of political truth claims and their distinct elements. This framework enables interrogation and understanding of the current state of epistemic contestation and change. The rise of both populist and deliberative approaches to democracy, which we use as key examples, are indicators of a gradual shift towards a greater importance of authenticity in the public sphere. We nuance this proposition by distinguishing between different forms of authenticity employed by populist and deliberative politics: communicative authenticity in deliberative politics and original and personal authenticity in populist politics.
Analysing online forums to identify information needs and knowledge gaps in patients with left ventricular assist devices: a qualitative study
Authors: Abdelhadi Nasra , Klein Stav , Shahar Moni , Melnikov Semyon 
Published: June 2024

Abstract

Aims
The aim of the study was to explore the knowledge and unmet informational needs of candidates for left ventricular assist device (LVAD), as well as of patients, caregivers, and family members, by analysing social media data from the MyLVAD.com website.

Methods and results
A qualitative content analysis method was employed, systematically examining and categorizing forum posts and comments published on the MyLVAD.com website from March 2015 to February 2023. The data were collected using an automated script to retrieve threads from MyLVAD.com, focusing on genuine questions reflecting information and knowledge gaps. The study received approval from an ethics committee. The research team developed and continuously updated categorization matrices to organize information into categories and subcategories systematically. From 856 posts and comments analysed, 435 contained questions representing informational needs, of which six main categories were identified: clothing, complications/adverse effects, LVAD pros and cons, self-care, therapy, and recent LVAD implantation. The self-care category, which includes managing the driveline site and understanding equipment functionality, was the most prominent, reflecting nearly half of the questions. Other significant areas of inquiry included complications/adverse effects and the pros and cons of LVAD.

Conclusion
The analysis of social media data from MyLVAD.com reveals significant unmet informational needs among LVAD candidates, patients, and their support networks. Unlike traditional data, this social media-based research provides an unbiased view of patient conversations, offering valuable insights into their real-world concerns and knowledge gaps. The findings underscore the importance of tailored educational resources to address these unmet needs, potentially enhancing LVAD patient care.
Digest: Resource limitation as a mechanism for constraining the evolution of virulence in malaria parasites
Authors: Lockwood Sophie 
Published: June 2024

Abstract
The virulence of parasites is expected to reflect an evolutionary tradeoff between increasing proliferation rates that enhance transmission and host mortality which curtails transmission. However, host resource availability may also limit parasites’ proliferation rate. To understand the role of resource limitation as a driver of virulence evolution, Pak et al. (2024) use a within-host model of red blood cell (RBC) invasion by Plasmodium chabaudi. They find that within-host resource consumption limits the evolution of the parasite’s proliferation rate, as the depletion of RBCs during infection results in intermediate optimal virulence. These results suggest that resource limitation, rather than host mortality, may drive the evolution of virulence.