bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and Predictors of Depression among Adult Male Patients with Type 2 Diabetes Mellitus Attending General Outpatient Clinic in a Tertiary Hospital in Northern Nigeria
Authors: Azudialu Bede C , Timothy Njoka , Emmanuel Ogwuche , Frances Ogunnaya , Obi-nwosu Amaka , Nkem Benjamin I 
Published: June 2024

Background: Diabetes is a chronic disease that occurs when the pancreas does not produce enough insulin, no insulin or when the body cannot effectively use the insulin it produces. The majority of people with diabetes have type 2 diabetes (T2DM). According to the International Diabetes Federation “diabetes is one of the largest global health emergencies of the 21st century”. The World Health Organization (WHO) ranked depression as the fourth most common disease in 2019. The connection between depression and type 2 diabetes was recognized as early as in the 17th century. Today, depression and type 2 diabetes have become a great global challenge.
Objective: To determine the prevalence of depression among adult males with type 2 DM attending General Outpatient Clinic of Federal Medical Center, Keffi Nigeria.
Methodology: The study design was hospital- based cross-sectional descriptive study on adult male diabetic patients on follow up at the GOPC of FMC Keffi.
Systematic random sampling method was used to select participants into the study. A total of 209 participants were recruited into this study, after obtaining informed consent from them. Data collected from the study participants included socio-demographic data, depression was assessed using the Hamilton Depression Rating Scale (HDRS, Biochemical Measurement (fasting blood sugar) was taken using the glucometer kits- (ACCU-CHEK Active).
Results: The age range of the study population is between 40 and 75 years with majority within 50-59 years (35.5%). A total of 101 (48.3%) of the study participants were identified by the Hamilton’s depression rating scale to be depressed, while 108 (51.7%) had no depression. Among the participants, the risk of developing depression was significantly(p=0.001) found with being divorced or unmarried and unemployment, poor glycaemic control, ingestion of alcohol, cigarette smoking, increase duration of diabetes and presence of erectile dysfunction.
Conclusion: In this study, the prevalence of depression was 48.3%. Depression is a highly prevalent health problem that is both under-diagnosed and under treated and affects the quality of life of a large number of men with type 2 diabetes mellitus. There is need to screen all diabetics for depression at any clinic visit in view of the observed high prevalence.
Microduplication of Xq24 and Hartsfield syndrome with holoprosencephaly, ectrodactyly, and clefting
Authors: Takenouchi Toshiki , Okuno Hironobu , Kosaki Rika , Ariyasu Daisuke , Torii Chiharu , Momoshima Suketaka , Harada Naoki , Yoshihashi Hiroshi , Takahashi Takao , Awazu Midori , Kosaki Kenjiro 
Published: August 2012

AbstractThe combination of holoprosencephaly and ectrodactyly, also known as Hartsfield syndrome, represents a unique genetic entity. An X‐linked recessive mode of transmission has been suggested for this condition based on the observation that male patients have preferentially been affected. Thus far, no candidate genes have been suggested on the X chromosome. We report a male patient with a full‐blown Hartsfield syndrome phenotype who had microduplication at Xq24 involving four genes. He presented with bilateral ectrodactyly of the hands (both hands had four fingers with a deep gap between the 2nd and 3rd digits), cleft lip and palate, and a depressed nasal bridge. Magnetic resonance imaging of the brain revealed lobar holoprosencephaly. His G‐banded karyotype was normal. Array comparative genomic hybridization (CGH) using the Agilent 244K Whole Human Genome CGH array revealed a microduplication at Xq24 of 210 kb. Parental testing revealed that the deletion was derived from the asymptomatic mother. Of the genes on the duplicated interval, the duplications of SLC25A43 and SLC25A5 appeared to be the most likely to explain the patient's phenotype. From a clinical standpoint, it is important to point out that the propositus, who performs relatively well with holoprosencephaly and has a developmental quotient around 70, has survived multiple life‐threatening episodes of hypernatremia. Awareness of the risk of hypernatremia is of great importance for the anticipatory management of patients with ectrodactyly and an oral cleft, even in the absence of overt hypotelorism. © 2012 Wiley Periodicals, Inc.
A novel nonsense CDK5RAP2 mutation in a Somali child with primary microcephaly and sensorineural hearing loss
Authors: Pagnamenta Alistair T. , Murray Jennie E. , Yoon Grace , Akha Elham Sadighi , Harrison Victoria , Bicknell Louise S. , Ajilogba Kaseem , Stewart Helen , Kini Usha , Taylor Jenny C. , Keays David A. , Jackson Andrew P. , Knight Samantha J.L. 
Published: August 2012

AbstractPrimary microcephaly is a genetically heterogeneous condition characterized by reduced head circumference (−3 SDS or more) and mild‐to‐moderate learning disability. Here, we describe clinical and molecular investigations of a microcephalic child with sensorineural hearing loss. Although consanguinity was unreported initially, detection of 13.7 Mb of copy neutral loss of heterozygosity (cnLOH) on chromosome 9 implicated the CDK5RAP2 gene. Targeted sequencing identified a homozygous E234X mutation, only the third mutation to be described in CDK5RAP2, the first in an individual of non‐Pakistani descent. Sensorineural hearing loss is not generally considered to be consistent with autosomal recessive microcephaly and therefore it seems likely that the deafness in this individual is caused by the co‐occurrence of a further gene mutation, independent of CDK5RAP2. Nevertheless, further detailed clinical descriptions of rare CDK5RAP2 patients, including hearing assessments will be needed to resolve fully the phenotypic range associated with mutations in this gene. This study also highlights the utility of SNP‐array testing to guide disease gene identification where an autosomal recessive condition is plausible. © 2012 Wiley Periodicals, Inc.
Unexpected Facile Formation of an Achaetolide Dimer
Authors: Zhang Shao‐Min , Lu Xiao‐Wei , Wu Yikang 
Published: August 2012

AbstractRing‐closing metathesis (RCM)‐based approaches to achaetolide usually lead to smooth ring closures. In contrast, lactonization gave none of the expected monolactone, but instead a diolide was obtained as the predominant product. This result not only illustrates that the current method is a facile “one‐pot” route to dilactones, but it also demonstrates an unnoticed advantage of RCM over lactonization for the formation of the given ring system.
Genetic deletion of CD36 enhances injury after acute neonatal stroke
Authors: Woo Moon‐Sook , Wang Xia , Faustino Joel V. , Derugin Nikita , Wendland Michael F. , Zhou Ping , Iadecola Costantino , Vexler Zinaida S. 
Published: August 2012

AbstractObjective:The scavenger receptor CD36 is injurious in acute experimental focal stroke and neurodegenerative diseases in the adult. We investigated the effects of genetic deletion of CD36 (CD36ko) on acute injury, and oxidative and inflammatory signaling after neonatal stroke.Methods:Postnatal day 9 CD36ko and wild‐type (WT) mice were subjected to a transient middle cerebral artery occlusion (MCAO). Injury, phagocytosis of dying cells, and CD36 inflammatory signaling were determined.Results:While the volume of tissue at risk by diffusion‐weighted magnetic resonance imaging during MCAO was similar in neonatal CD36ko and WT mice, by 24 hours after reperfusion, injury was more severe in CD36ko and was associated with increased caspase‐3 cleavage and reduced engulfment of neurons expressing cleaved caspase‐3 by activated microglia. No significant superoxide generation was observed in activated microglia in injured WT, whereas increased superoxide production in vessels and nuclear factor (NF)‐κB activation induced by MCAO were unaffected by lack of CD36. Lyn expression was higher in injured CD36ko, and cell type‐specific patterns of Lyn expression were altered; Lyn was expressed in endothelial cells and microglia in WT but predominantly in dying neurons in CD36ko.Interpretation:Lack of CD36 results in poorer short‐term outcome from neonatal focal stroke due to lack of attenuation of NF‐κB–mediated inflammation and diminished removal of apoptotic neuronal debris. Although inhibition of CD36 does not seem to be a good therapeutic target for protection after acute neonatal stroke, as it is after adult stroke, seeking better understanding of CD36 signaling in particular cell populations may reveal important therapeutic targets for neonatal stroke. ANN NEUROL 2012;72:961–970
Could European marine conservation policy benefit from systematic conservation planning?
Authors: Giakoumi Sylvaine , Katsanevakis Stelios , Vassilopoulou Vassiliki , Panayotidis Panayotis , Kavadas Stefanos , Issaris Yiannis , Kokkali Athina , Frantzis Alexandros , Panou Aliki , Mavrommati Georgia 
Published: August 2012

ABSTRACTThe Natura 2000 network of protected areas aims to assure the long‐term survival of Europe's most valuable and threatened species and habitats. Yet, evidence shows that the present network fails to represent effectively the biodiversity of the region.Priority areas for conservation of coastal and offshore biodiversity features in the Greek Ionian Sea were identified, based on the principles of systematic conservation planning (SCP). SCP is a transparent method for the design of MPA networks and is considered more efficient and successful in representing the biodiversity of a region.The prioritization software Marxan was used and three scenarios with different sets of targets for 17 (high and low priority) conservation features were produced. These scenarios explicitly took into account socio‐economic factors expressed as a single cost metric, weighting different economic sectors in proportion to their contribution to the GDP of the region. Then results were compared with the existing Natura 2000 sites in terms of goal achievement, area requirements, and cost.The solutions produced by the systematic approach demanded less area and lower cost to achieve the goals set, when the selection of all Natura 2000 sites was not forced. Existing Natura 2000 sites alone failed to achieve conservation goals for some EU priority and other important coastal and offshore habitats and species of the Mediterranean Sea.It is suggested that the use of systematic conservation planning and related computational tools could benefit the selection of European marine priority areas, especially in the context of ecosystem‐based marine spatial management. Copyright © 2012 John Wiley & Sons, Ltd.
Synthesis and Characterization of Thiazolo‐ and Thiazinomorphinans and Their Intermediate Products as Novel Opioid‐Active Derivatives
Authors: Sipos Attila , Follia Valeria , Berényi Sándor , Antus Sándor , Schmidhammer Helmut , Spetea Mariana 
Published: August 2012

AbstractA new procedure was elaborated for the synthesis of potentially opioid‐active thiazolo‐ and thiazinomorphinans. These derivatives and some intermediates related with the synthesis were tested in opioid receptor binding studies. Two compounds showed remarkable µ opioid activities and specificities. The ligand‐stimulated [35S]GTPγS assays confirmed for both compounds the potent full agonist profile at the µ receptor and for the benzothiazinomorphinan derivative also the δ receptor full agonist character. The structures of these remarkably effective compounds were analyzed with the aid of computational chemistry calculations.
Investigating Magnetic Ghosts on an Early Middle Age Settlement: Comparison of Data from Stripped and Non‐stripped Areas
Authors: Simon François‐Xavier , Koziol Agnieszka , Thiesson Julien 
Published: August 2012

ABSTRACTStatute laws concerning preventative archaeology adopted in France in 2001 for threatened sites required development of evaluation techniques. The common methodology used during the past 10 years has been extensive excavation. This method delivers a direct record of the discovered archaeological features and of their distribution. However, the success of visual observation can be variable, depending on geological context and the feasibility of envisaging the entire archaeological settlement from the part that is observed. We report here a case study from an early Middle Age settlement located on a floodplain. It was partially excavated and the alluvial context makes the features difficult to recognize for archaeologists. We show how the geophysical survey complemented the archaeological survey and allowed the detection of previously unrecognized features. In a second step, we compare the results of surveys with magnetic and electromagnetic methods on a topsoil stripped area and the neighbouring surface. From this analysis we conclude that a significant part of the unrecognized features discovered were present above the level of stripping. This example underlines that the practice of topsoil stripping has to be reconsidered, and should be integrated with geophysical survey to limit the potential loss of archaeological information. Copyright © 2012 John Wiley & Sons, Ltd.
Tracing High‐temperature Crafts: Magnetometry on the Island of Gotland, Sweden
Authors: Gustafsson Ny Björn , Viberg Andreas 
Published: August 2012

ABSTRACTGradiometer surveys have been carried at three Iron Age and early medieval sites on the island of Gotland, Sweden. Previous experiences of poorly executed magnetic surveys combined with a misconception among archaeologists that the Gotlandic sedimentary bedrock would preclude the success of any magnetic investigations on the island have, until now, prevented the extended use of the method within archaeological projects. The purpose of the present study was to test this presumption while searching for in situ buried remains of high‐temperature crafts, such as metal and glass working. The location of the survey grids was guided by concentrations of previously recovered high‐temperature craft finds from metal detector surveys and excavations. The results indicate that the magnetometer is a valuable tool for detecting the presence of preserved high‐temperature craft structures in the Gotlandic soil. An additional result indicates that in this area the magnetometer can easily identify remains of ploughed‐over Iron Age stone foundation houses and stone boundary walls. This is possible because of the prehistoric population's preference of using glacially deposited, igneous rocks in such constructions. It can thus be concluded that the uniformly non‐magnetic character of the Gotlandic bedrock provides excellent conditions for conducting magnetic surveys. Copyright © 2012 John Wiley & Sons, Ltd.
Ternary Polymer Composite of Graphene, Carbon Nitride, and Poly(3‐hexylthiophene): an Efficient Photocatalyst
Authors: Gawande Sandeep , Thakare Sanjay R. 
Published: August 2012

AbstractHerein we report on the synthesis of a ternary polymer composite of graphene, carbon nitride, and poly(3‐hexylthiophene) (G‐g‐C3N4‐P3HT) by a solvothermal method. The prepared polymer composite catalysts are characterized by TEM, XRD, FTIR spectroscopy, and photoluminescence techniques for their morphology, structure and photocatalytic efficiency. Graphene‐loaded polymer composites of carbon nitride (g‐C3N4) and poly(3‐hexylthiophene) act as efficient photocatalysts for waste water treatment. Methylene blue is used as the model pollutant and the rate of its photocatalytic degradation with G‐g‐C3N4‐P3HT is three times higher than that achieved with a g‐C3N4‐P3HT composite.
Resource Efficiency in Changing Global Markets for Industrial Metals
Authors: Deike Rüdiger 
Published: August 2012

AbstractDurch oligopolistische Strukturen hat die Volatilität der Rohstoffmärkte deutlich zugenommen. Extreme Beispiele dafür sind die Preissteigerungen bei den Seltenen Erden, aber auch bei anderen Industriemetallen sind aufgrund ähnlicher Marktmechanismen identische Entwicklungen zu identifizieren. Steigende Preise führen aber auch dazu, dass bisher unwirtschaftliche Recyclingverfahren eventuell doch ökonomisch erfolgreich betrieben werden können. Mit Stahl und Gusseisen sind bereits heute schon Recyclingprozesse in weitgehend geschlossenen Stoffkreisläufen realisiert, die zudem unendlich oft wiederholt werden können. Hingegen sind in den Fällen, in denen die Wertstoffe in einer ausgeprägten dissipativen Verteilung in den Reststoffen vorliegen, aufwendigere Prozesse notwendig, da hier komplexere Problemstellungen zu lösen sind.
Optimized Process Control for Resources Efficient Steelmaking in Converter Process
Authors: Kleimt Bernd , Schlautmann Martin , Weinberg Matthias , Bongers Jörn , Berg Peter , Ide Norman 
Published: August 2012

AbstractDie Entkohlung einer Stahlschmelze über Aufblasen von Sauerstoff im Konverterprozess ist mit einem unerwünschten Abbrand der metallischen Einsatzstoffe verbunden. Durch eine Optimierung der Prozessführung für den Blasstahlkonverter auf der Grundlage von dynamischen Modellen und innovativen messtechnischen Verfahren zur schnellen Abgasanalyse kann die Ressourceneffizienz des Konverterprozesses hinsichtlich des metallischen Ausbringens signifikant erhöht werden.
Expression of nuclear factor one A and ‐B in the olfactory bulb
Authors: Plachez Céline , Cato Kathleen , McLeay Robert C. , Heng Yee Hsieh Evelyn , Bailey Timothy L. , Gronostasjki Richard M. , Richards Linda J. , Puche Adam C. , Piper Michael 
Published: August 2012

AbstractThe nuclear factor one (NFI) family of transcription factors consists of four members in vertebrates, NFIA, NFIB, NFIC, and NFIX, which share a highly conserved N‐terminal DNA‐binding domain. NFI genes are widely expressed in the developing mouse brain, and mouse mutants lacking NFIA, NFIB, or NFIX exhibit developmental deficits in several areas, including the cortex, hippocampus, pons, and cerebellum. Here we analyzed the expression of NFIA and NFIB in the developing and adult olfactory bulb (OB), rostral migratory stream (RMS), and subventricular zone (SVZ). We found that NFIA and NFIB are expressed within these regions during embryonic and postnatal development and in the adult. Immunohistochemical analysis using cell‐type‐specific markers revealed that migrating neuroblasts in the adult brain express NFI transcription factors, as do astrocytes within the RMS and progenitor cells within the SVZ. Moreover, astrocytes within the OB express NFIA, whereas mitral cells within the OB express NFIB. Taken together these data show that NFIA and NFIB are expressed in both the developing and the adult OB and in the RMS and SVZ, indicative of a regulatory role for these transcription factors in the development of this facet of the olfactory system. J. Comp. Neurol., 520:3135–3149, 2012. © 2012 Wiley Periodicals, Inc.
Visualizing corticotropin‐releasing hormone receptor type 1 expression and neuronal connectivities in the mouse using a novel multifunctional allele
Authors: Kühne Claudia , Puk Oliver , Graw Jochen , Hrabě de Angelis Martin , Schütz Günther , Wurst Wolfgang , Deussing Jan M. 
Published: August 2012

AbstractThe corticotropin‐releasing hormone (CRH) and its type 1 receptor (CRHR1) play a central role in coordinating the endocrine, autonomic, and behavioral responses to stress. A prerequisite to functionally dissect the complexity of the CRH/CRHR1 system is to unravel the identity of CRHR1‐expressing neurons and their connectivities. Therefore, we used a knockin approach to genetically label CRHR1‐expressing cells with a tau‐lacZ (tZ) reporter gene. The distribution of neurons expressing β‐galactosidase in the brain and the relative intensity of labeling is in full accordance with previously described Crhr1 mRNA expression. Combining the microtubule‐binding properties of TAU with the Cre‐loxP system allowed to direct the β‐galactosidase to proximal dendrites, and in particular to axons. Thereby, we were able to visualize projections of CRHR1 neurons such as glutamatergic and dopaminergic afferent connections of the striatum and GABAergic CRHR1‐expressing neurons located within its patch compartment. In addition, the tZ reporter gene revealed novel details of CRHR1 expression in the spinal cord, skin, and eye. CRHR1 expression in the retina prompted the identification of a new physiological role of CRHR1 related to the visual system. Besides its reporter properties, this novel CRHR1 allele comprises the possibility to conditionally restore or delete CRHR1 via Flp and Cre recombinase, respectively. Finally, the allele is suitable for further manipulations of the CRHR1 locus by recombinase‐mediated cassette exchange. Taken together, this novel mouse allele will significantly facilitate the neuroanatomical analysis of CRHR1 circuits and opens up new avenues to address CRHR1 function in more detail. J. Comp. Neurol., 520:3150–3180, 2012. © 2012 Wiley Periodicals, Inc.
Transitory and activity‐dependent expression of neurogranin in olfactory bulb tufted cells during mouse postnatal development
Authors: Gribaudo S. , Bovetti S. , Friard O. , Denorme M. , Oboti L. , Fasolo A. , De Marchis S. 
Published: August 2012

AbstractNeurogranin (Ng) is a brain‐specific postsynaptic calmodulin‐binding protein involved in synaptic activity‐dependent plasticity. In the adult olfactory bulb (OB), Ng is expressed by a large population of GABAergic interneurons in the granule cell layer. We show here that, during postnatal development, Ng is also expressed by OB neurons in the superficial external plexiform layer (sEPL) and glomerular layer (GL). These Ng‐positive neurons display morphological and neurochemical features of superficial and external tufted cells. Ng expression in these cells is transient during OB development: few elements express Ng at postnatal day (P) 5, increasing in number and reaching a peak at P10, then progressively decreasing. At P30, Ng is rarely detectable in these neurons. Ng expression in developing tufted cells is also modulated at the cellular level: at earlier stages, Ng labeling is distributed throughout the cell body and dendritic arborization in the GL, but, at P20, when the glomerular circuits are fully matured, Ng becomes restricted to the soma and proximal portion of tufted cell apical dendrites. We show that olfactory deprivation at early postnatal stages induces a strong increase in Ng‐positive tufted cells from P10 to P20, whereas no changes have been observed following olfactory deprivation in adult mice. These findings demonstrate that Ng expression in sEPL‐GL is restricted to developmental stages and indicate its activity‐dependent regulation in a time window critical for glomerular circuit development, suggesting a role for Ng in maturation and dendritic remodeling of tufted cells. J. Comp. Neurol., 520:3055–3069, 2012. © 2012 Wiley Periodicals, Inc.