bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rhodium(I)‐Catalyzed Intramolecular Carbonylative [2+2+1] Cycloadditions and Cycloisomerizations of Bis(sulfonylallene)s
Authors: Kawamura Takamasa , Inagaki Fuyuhiko , Narita Syu , Takahashi Yasuhito , Hirata Shuichi , Kitagaki Shinji , Mukai Chisato 
Published: March 2010

AbstractNovel [{RhCl(CO)dppp}2]‐catalyzed intramolecular carbonylative [2+2+1] cycloadditions of bis(phenylsulfonylallene) derivatives under CO, leading to the facile formation of bis(phenylsulfonyl)bicyclo[n.3.0] frameworks (n=4–6), have been developed. The terminal double bonds of both allenyl moieties served exclusively as the two π‐components. In particular, this newly developed method was shown to be a powerful tool for the construction of bicyclo[6.3.0]undecadienones, which have hardly been prepared by the known Pauson–Khand (‐type) reactions. The bicyclo[7.3.0]dodecadienone homologue (one extra carbon) could be formed in rather low yields. Alternatively, novel cycloisomerizations of bis(phenylsulfonylallene) derivatives with catalysis by the same RhI complex under N2 readily produced the 3,4‐dimethylene‐2,5‐bis(phenylsulfonyl)cyclononene and the corresponding cyclooctene and cycloheptene frameworks.
Effect of kinetic models on hot spot temperature prediction for phthalic anhydride production in a multitubular packed bed reactor
Authors: Orozco G. A. , Gomez J. R. , Sanchez O. F. , Gil I. D. , Duran A. 
Published: March 2010

AbstractAlthough there are several kinetic models for the production of phthalic anhydride from the partial oxidation of o‐xylene, only few studies have compared the effect of the kinetic model on the prediction of the hot‐spot temperature. In this work, the predicted temperature profile for the partial oxidation of o‐xylene to phthalic anhydride in a multitubular packed bed reactor was obtained for different kinetic mechanisms using one‐dimensional pseudo‐homogeneous and heterogeneous models. The predicted temperature profile using the one‐dimensional heterogeneous model with the kinetic model of Calderbank et al. but with the adjusted kinetic and transport parameters proposed by Anastasov presented a good correlation with regard to experimental data. Nevertheless, in the hot‐spot zone deviations, up to 30 K were presented. In conclusion, the temperature performance in the production of phthalic anhydride is suitably predicted by the one‐dimensional heterogeneous model and the Calderbank et al.'s kinetic model. Though, prediction using bidimensional models should be done to establish the best correlation with experimental data.
Design, Synthesis, and Biological Evaluation of 3‐Benzazepin‐1‐ols as NR2B‐Selective NMDA Receptor Antagonists
Authors: Tewes Bastian , Frehland Bastian , Schepmann Dirk , Schmidtke Kai‐Uwe , Winckler Thomas , Wünsch Bernhard 
Published: March 2010

AbstractCleavage and reconstitution of a bond in the piperidine ring of ifenprodil (1) leads to 7‐methoxy‐2,3,4,5‐tetrahydro‐1H‐3‐benzazepin‐1‐ols, a novel class of NR2B‐selective NMDA receptor antagonists. The secondary amine 7‐methoxy‐2,3,4,5‐tetrahydro‐1H‐3‐benzazepin‐1‐ol (12), which was synthesized in six steps starting from 2‐phenylethylamine3, represents the central building block for the introduction of several N‐linked residues. A distance of four methylene units between the basic nitrogen atom and the phenyl residue in the side chain results in high NR2B affinity. The 4‐phenylbutyl derivative13(WMS‐1405,Ki=5.4 nM) and the conformationally restricted 4‐phenylcyclohexyl derivative31(Ki=10 nM) represent the most potent NR2B ligands of this series. Whereas13shows excellent selectivity, the 4‐phenylcyclohexyl derivative31also interacts with σ1(Ki=33 nM) and σ2receptors (Ki=82 nM). In the excitotoxicity assay the phenylbutyl derivative13inhibits the glutamate‐induced cytotoxicity with an IC50value of 360 nM, indicating that13is an NMDA antagonist.
Serine‐ and mannose‐modified liposomal contrast agent for computed tomography: evaluation of the enhancement in rabbit liver VX‐2 tumor model
Authors: Okada Masahiro , Isoda Takeshi , Kumano Seishi , Kagawa Yuki , Araki Tetsuro , Onishi Hiromitsu , Hori Masatoshi , Kim Tonsok , Motokui Yasuyuki , Wada Takeshi , Murakami Takamichi 
Published: March 2010

AbstractKupffer cell imaging is a powerful tool for the detection of liver cancer. This diagnostic procedure depends on the faculty of the reticuloendothelial system (RES) which takes up foreign bodies, including small particles. The current study aimed to develop a novel RES targeting liposomal contrast agent that functionalized with serine or mannose, the moiety specifically binding to a corresponding receptor on phagocytic cells. Liposomes loaded with non‐ionic X‐ray contrast media, Iohexol, were prepared by supercritical carbon dioxide reverse‐phase evaporation method and were intravenously injected to healthy rabbits in order to evaluate the liver parenchymal enhancement in X‐ray computed tomography (CT). From 10 to 40 min after injection, the mean enhancement value of the liver parenchyma approached 45 and 34 Hounsfield units (HU) when serine‐modified iodinated liposomal contrast agent (ILCA) and mannose‐modified ILCA were applied, respectively. The tumor‐to‐liver contrast values were also evaluated after the administration of the prepared ILCA to rabbits with VX‐2 carcinoma. For serine‐modified ILCA, tumor‐to‐liver contrast was 82 HU at 1 min and >24 HU at 10–40 min; for mannose‐modified ILCA, the values were 58 HU at 0.5 min and >21 HU at 10–40 min. These vales estimated from the region of intrest and the imaging figures of liver indicate the potential of ILCA for clinical use. Copyright © 2010 John Wiley & Sons, Ltd.
Impact of recent screening on predicting the outcome of prostate cancer biopsy in men with elevated prostate‐specific antigen
Authors: Vickers Andrew J. , Cronin Angel M. , Aus Gunnar , Pihl Carl‐Gustav , Becker Charlotte , Pettersson Kim , Scardino Peter T. , Hugosson Jonas , Lilja Hans 
Published: March 2010

AbstractBACKGROUND:Risk models to predict prostate cancer on biopsy, whether they include only prostate‐specific antigen (PSA) or other markers, are intended for use in all men of screening age. However, the association between PSA and cancer probably depends on a man's recent screening history.METHODS:The authors examined the effect of prior screening on the ability to predict the risk of prostate cancer by using a previously reported, 4‐kallikrein panel that included total PSA, free PSA, intact PSA, and human kallikrein‐related peptidase 2 (hK2). The study cohort comprised 1241 men in Gothenburg, Sweden who underwent biopsy for elevated PSA during their second or later visit for the European Randomized Study of Screening for Prostate Cancer. The predictive accuracy of the 4‐kallikrein panel was calculated.RESULTS:Total PSA was not predictive of prostate cancer. The previously published 4‐kallikrein model increased predictive accuracy compared with total PSA and age alone (area under the curve [AUC], 0.66 vs 0.51; P < .001) but was poorly calibrated and missed many cancers. A model that was developed with recently screened men provided important improvements in discrimination (AUC, 0.67 vs 0.56; P < .001). Using this model reduced the number of biopsies by 413 per 1000 men with elevated PSA, missed 60 of 216 low‐grade cancers (Gleason score ≤6), but missed only 1 of 43 high‐grade cancers.CONCLUSIONS:Previous participation in PSA screening dramatically changed the performance of statistical models that were designed to predict biopsy outcome. A 4‐kallikrein panel was able to predict prostate cancer in men who had a recent screening history and provided independent confirmation that multiple kallikrein forms contribute important diagnostic information for men with elevated PSA. Cancer 2010. © 2010 American Cancer Society.
A single nucleotide polymorphism in the alcohol dehydrogenase 7 gene (alanine to glycine substitution at amino acid 92) is associated with the risk of squamous cell carcinoma of the head and neck
Authors: Wei Sheng , Liu Zhensheng , Zhao Hui , Niu Jiangong , Wang Li‐E , El‐Naggar Adel K. , Sturgis Erich M. , Wei Qingyi 
Published: March 2010

AbstractBACKGROUND:The authors conducted a hospital‐based study of 1110 patients with squamous cell carcinoma of the head and neck (SCCHN) and a control group of 1129 patients to replicate the associations reported by a recent, large European study between 2 potentially functional single nucleotide polymorphisms (SNPs) of the alcohol dehydrogenase (ADH) genes, a substitution in ADH1B at amino acid 48 from arginine to histidine (R48H) (reference SNP number [rs]1229984; guanine to adenine [G→A]) and a substitution in ADH7 at amino acid 92 from alanine to glycine (A92G) (rs1573496; cytosine to guanine [C→G]), and the risk of squamous cell carcinoma of the head and neck (SCCHN).METHODS:Multivariate logistic regression was used to calculate adjusted odds ratios (ORs) and 95% confidence intervals (CIs). False‐positive report probabilities (FPRPs) also were calculated for significant findings.RESULTS:The ADH7 A92G GG and combined CG + GG genotypes were associated with a decreased risk of SCCHN (GG: adjusted OR, 0.32; 95% CI, 0.13‐0.82; CG + GG: adjusted OR, 0.74; 95% CI, 0.59‐0.94; FPRP, .098) compared with the CC genotype. This association was also evident in subgroups of older patients (aged >57 years), men, former smokers, patients with oral cancer, and patients with N) lymph node status (P < .05 for all); however, such associations were not observed for the ADH1B R48H SNP.CONCLUSIONS:The current results support the ADH7 A92G SNP as a marker for the risk of SCCHN in non‐Hispanic white populations. Cancer 2010. © 2010 American Cancer Society.
Adjuvant therapy and survival after resection of pancreatic adenocarcinoma
Authors: Mayo Skye C. , Austin Donald F. , Sheppard Brett C. , Mori Motomi , Shipley Donald K. , Billingsley Kevin G. 
Published: March 2010

AbstractBACKGROUND:The use of adjuvant chemoradiation for pancreatic adenocarcinoma (PAC) is accepted in North America, but there is a paucity of data to support this practice. The relation between adjuvant therapy and survival was assessed in a population‐based cohort of patients with PAC.METHODS:A review was conducted of all cases of resected PAC from 1996 to 2003 using data from the state cancer registry augmented with data from primary medical record review. Use of adjuvant therapy was ascertained from registry data. Survival was assessed using the Kaplan‐Meier method, and a Cox proportional hazards model was developed for multivariate analysis.RESULTS:A total of 298 patients from 27 hospitals met criteria for inclusion. There were 228 patients (76.5%) who were resected with curative intent, with a median overall survival of 12 months. The 6‐month, 1‐year, and 5‐year survival rates were 80.2%, 58.4%, and 6.7%, respectively. Of the 228 patients resected, 122 (53.5%) received adjuvant treatment and had a median survival of 13.0 months versus 11.0 months for those with no adjuvant treatment (P= .16). After adjustment for surrogates of performance status, significant predictors of overall survival included no weight loss, T1/T2 pathologic stage, a microscopically complete resection (R0), and receipt of adjuvant therapy.CONCLUSIONS:An R0 resection and adjuvant therapy were found to be independently associated with an increase in overall survival in patients with resected PAC. These data underscore the importance of adjuvant therapy in resected PAC and the need for ongoing clinical trials to refine the efficacy and timing of adjuvant therapy in this disease. Cancer 2010. © 2010 American Cancer Society.
Trends in oropharyngeal and oral cavity cancer incidence of human papillomavirus (HPV)‐related and HPV‐unrelated sites in a multicultural population
Authors: Auluck Ajit , Hislop Greg , Bajdik Chris , Poh Catherine , Zhang Lewei , Rosin Miriam 
Published: March 2010

AbstractBACKGROUND:There is a growing recognition of the involvement of human papilloma virus infection in the etiology of head and neck cancers at some sites, mainly the base of the tongue, tonsils, and other oropharynx (hereafter termed oropharyngeal cancer). Other oral sites (hereafter termed oral cavity cancer [OCC]) show a stronger association with tobacco and alcohol. Little is known about the ethnic variation in incidence for these cancers. This study determined incidence rates of OCC and oropharyngeal cancer among South Asian, Chinese, and the general population in British Columbia, Canada.METHODS:Patients with OCC and oropharyngeal cancer diagnosed from 1980 to 2006 were identified through the British Columbia cancer registry, and surname lists were used to establish ethnicity. Age‐adjusted incidence rates were determined for these cancers by sex, topographical site, and ethnicity, and temporal trends were examined.RESULTS:Age‐adjusted incidence rates have been decreasing for OCC and increasing for oropharyngeal cancer in the general population for both sexes, with men having higher incidence rates than women. Ethnic differences were found, with the highest age‐adjusted incidence rates for OCC for men in South Asians and for women in Chinese, and with the highest age‐adjusted incidence rates for oropharyngeal cancer for men in Chinese and for women in the general population. Differences were also found for OCC topographical sites by sex and ethnicity.CONCLUSIONS:The incidence of oropharyngeal cancer has now surpassed OCC in the British Columbia male population. Ethnic minorities are at higher risk than the general population for both OCC and oropharyngeal cancer for men, and for OCC for women. Cancer 2010. © 2010 American Cancer Society.
The role of fluorescence in situ hybridization and polymerase chain reaction in the diagnosis and classification of lymphoproliferative disorders on fine‐needle aspiration
Authors: Zhang Songlin , Abreo Fleurette , Lowery‐Nordberg Mary , Veillon Diana M. , Cotelingam James D. 
Published: March 2010

AbstractBACKGROUND:Fine‐needle aspiration (FNA) has been used in the evaluation of lymphadenopathy for a long time and is highly reliable in the identification of metastatic malignancies. However, the role of FNA in the assessment of new lymphoproliferative disorders continues to be a subject of debate. The objective of the current study was to evaluate the role of molecular cytogenetic studies in FNA diagnoses of lymphoproliferative disorders.METHODS:A retrospective, computer‐based search for lymph node FNAs from 2006 to 2007 was performed. Cases with either fluorescence in situ hybridization (FISH) and/or polymerase chain reaction (PCR) studies were subjected to further analysis.RESULTS:In total, 243 lymph node FNAs were performed during the period, including 104 that were positive/suspicious for metastatic malignancies, 16 that were positive/suspicious for lymphomas, 15 that demonstrated atypical lymphoid proliferation, 73 that were reactive, 14 that were deemed granulomas, and 21 that were determined to be nondiagnostic. Molecular analysis included combined FISH/PCR in 4 cases, FISH only in 7 cases, and PCR only in 4 cases. By using multiplex PCR, 6 cases with atypical/negative flow cytometry results were diagnosed as 4 B‐cell lymphomas, 1 T‐cell lymphoma, and 1 reactive lymph node; and 4 cases that had atypical T cells determined by flow cytometry were diagnosed as reactive. One CD10‐negative follicular lymphoma and 2 cases with suspicious flow cytometry results were positive for t(14;18)(q32;q21) by FISH. Forty‐five cases had follow‐up histology with 3 false‐negative findings and no false‐positive results.CONCLUSIONS:In this study, multiplex PCR studies for immunoglobulin heavy‐chain or T‐cell receptor gene rearrangements were useful for demonstrating clonality, and FISH studies were able to detect translocations or gene rearrangements that allowed for the subclassification of B‐cell non‐Hodgkin lymphomas. Cancer (Cancer Cytopathol) 2010. © 2010 American Cancer Society.
Synthesis, characterization and gas sensing properties of flowerlike In2O3 composed of microrods
Authors: Lu Xifeng , Yu Qinqin , Wang Kang , Shi Luchuan , Liu Xing , Qiu Aiguo , Wang Lei , Cui Deliang 
Published: March 2010

AbstractFlowerlike structured In2O3 were successfully synthesized via a hydrothermal process and the subsequent calcinations. The obtained sample consists of microrods with an average diameter of 0.5‐1 μm and a length of 1‐3 μm. Structure and property of the sample were characterized by X‐ray powder diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The sensing properties towards trimethylamine (TMA) were examined at 200‐400 °C, which showed high sensitivity, better selectivity, and prompt response/recovery merits. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Temperature gradient controlled growth and optical properties of Er:BaY2F8 crystals
Authors: Yongfeng Ruan , Shouchao Zhang , Guanghui Li , Wei Zhu , Danli Wang , Lingcui Zhang 
Published: March 2010

AbstractSingle crystals of Erbium (Er) doped BaY2F8 have been obtained by the temperature gradient technique (TGT). No‐seed‐grown crystal of Er:BaY2F8, with the dimensions up to several centimeters, was obtained by self‐crystallization. The optimizations of various growth parameters were systemically investigated. The results indicated that the temperature gradient of 6‐7 K/mm and the cooling velocity less than 6 K/h were suitable for the crystal growth. The XRD data and the investigations on the growth striations by a stereo polarization microscope displayed that the [001] direction is the dominating direction for the crystal growth. The crystal grown by TGT often cracks along with the (100) plane, which is caused by the excessive decrease of the temperature during the crystal growth, for there is a rapid change in the thermal expansion curve of the BaY2F8 crystal in the temperature range from 800 °C to 900 °C. The spectral properties of Er:BaY2F8 single crystals have been studied and the effects of frequency up‐conversion of the crystals are reported. Spectral data suggest that the quality of Er:BaY2F8 crystal obtained by TGT method is good and the crystal has the potential application in laser devices. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Systematic Structural Coordination Chemistry ofp‐tert‐Butyltetrathiacalix[4]arene: Main Group Metal Complexes Other Than Those of Group 1
Authors: Bilyk Alexander , Dunlop John W. , Hall Annegret K. , Harrowfield Jack M. , Hosseini M. Wais , Koutsantonis George A. , Skelton Brian W. , White Allan H. 
Published: March 2010

AbstractIn extension of previous work involving structural characterisation of complex salts formed between main group 1 metal ions andp‐tert‐butyltetrathiacalixarene, LH4, the present study encompasses complexes with a wider array of main group 2, 13, 14 metal ions. For group 2, single‐crystal X‐ray structural characterisation of Ca(LH3)2·3dmf (1a), {Ca(LH2)·3dmf}2(1b), Ba(LH3)2·6dmf (2a) and BaCO3·3Ba(LH3)2·3H2O·3CH3CN·12.25CH2Cl2(2b) provides models for various coordination units. For group 13, this applies to {Ga(OH)(LH2)·3.5dmf}2(3), {In(LH)·4EtOH·2CH2Cl2}2(4a) and {In(OH)(LH2)·3CH2Cl2}4(4b), and for group 14, to OPb4(LH)2·6dmf·dmso·2H2O (5). Overall, these define mononuclear (1a,2a), binuclear (1b,3,4b) and tetranuclear (2b,4b,5) species. The calixarene cavities frequently include solvent molecules, though this capacity is clearly influenced by the nature of the bound metal ion(s) and their binding, as well as the associated impact on the conformation of the calixarene ligand(s).
Luminescent Platinum(II) Complexes Containing Cyclometallated Diaryl Ketimine Ligands: Synthesis, Photophysical and Computational Properties
Authors: Pandya Shashi U. , Moss Kathryn C. , Bryce Martin R. , Batsanov Andrei S. , Fox Mark A. , Jankus Vygintas , Al Attar Hameed A. , Monkman Andrew P. 
Published: March 2010

AbstractA new series of platinum(II) complexes containing cyclometallated diaryl ketimine ligands has been synthesised. The route involves reaction of diaryl ketimines with K[PtCl3(dmso)] to obtain trans‐[PtCl2(imine)(dmso)] species, which underwent cyclometallation upon heating in toluene to give [PtCl{Ar′(ArC=NH)}(dmso)] complexes 12b–17b. N‐Hydroxy and N‐phenyl analogues 18b and 21 were also synthesised. In complexes 19 and 20 the auxiliary chlorido and dmso ligands were replaced by an acetylacetonato ligand. The photophysical properties of the cyclometallated complexes are reported. The emission bands at λmax ≈ 450 and 550 nm are assigned to mixed‐ligand and MLCT states having significant singlet and triplet character, respectively. By varying the structure of the aromatic ligand the efficiency of phosphorescence can be increased to 4.3 % for 15b (Ar′ = 1‐naphthyl). Theoretical calculations show that the low‐energy transitions in all the cyclometallated systems involve mainly the frontier orbitals, HOMO and LUMO. These are mixed chlorido–metal–ligand to largely π*‐C=N transitions. Most of the observed phosphorescence data can be explained by the geometric change on going from the S0 to the T1 states. An organic light‐emitting device has been fabricated by using complex 15b as the emissive dopant in a poly(vinylcarbazole) host. Broad electroluminescence spanning the range 500–750 nm was observed.
Design of Bisphosphonate‐Terminated Dendrimers
Authors: Cavero Emma , Zablocka Maria , Caminade Anne‐Marie , Majoral Jean Pierre 
Published: March 2010

AbstractSeveral new methods for the synthesis of phosphorus dendrimers capped with biologically active azabisphosphonates are reported. Monomers bearing either azido or acetylenic groups were designed as building blocks either for attachment onto the surfaces of classical phosphorus dendrimers or for use in the construction of original dendrimers without the need for use of sensitive dichloro(monomethylhydrazino)thiophosphane.
Pyrazine Biosynthesis in Corynebacterium glutamicum
Authors: Dickschat Jeroen S. , Wickel Susanne , Bolten Christoph J. , Nawrath Thorben , Schulz Stefan , Wittmann Christoph 
Published: March 2010

AbstractThe volatile compounds released by Corynebacterium glutamicum were collected by use of the CLSA technique (closed‐loop stripping apparatus) and analysed by GC‐MS. The headspace extracts contained several acyloins and pyrazines that were identified by their synthesis or comparison to commercial standards. Feeding experiments with [2H7]acetoin resulted in the incorporation of labelling into trimethylpyrazine and tetramethylpyrazine. Several deletion mutants targeting genes of the primary metabolism were constructed to elucidate the biosynthetic pathway to pyrazines in detail. A deletion mutant of the ketol‐acid reductoisomerase was not able to convert the acetoin precursor (S)‐2‐acetolactate into the pathway intermediate (R)‐2,3‐dihydroxy‐3‐methylbutanoate to the branched amino acids. This mutant requires valine, leucine, and isoleucine for growth and produces significantly higher amounts and more different compounds of the acyloin and pyrazine classes. Gene deletion of the acetolactate synthase (AS) resulted in a mutant that is not able to convert pyruvate into (S)‐2‐acetolactate. This mutant also requires branched amino acids and produces only very small amounts of pyrazines likely from valine via the valine biosynthetic pathway operating in reverse order. A ΔASΔKR double mutant was constructed that does not produce any pyrazines at all. These results open up a detailed biosynthetic model for the formation of alkylated pyrazines via acyloins.