The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024
Authors: Shime Nobuaki , Nakada Taka‐aki , Yatabe Tomoaki , Yamakawa Kazuma , Aoki Yoshitaka , Inoue Shigeaki , Iba Toshiaki , Ogura Hiroshi , Kawai Yusuke , Kawaguchi Atsushi , Kawasaki Tatsuya , Kondo Yutaka , Sakuraya Masaaki , Taito Shunsuke , Doi Kent , Hashimoto Hideki , Hara Yoshitaka , Fukuda Tatsuma , Matsushima Asako , Egi Moritoki , Kushimoto Shigeki , Oami Takehiko , Kikutani Kazuya , Kotani Yuki , Aikawa Gen , Aoki Makoto , Akatsuka Masayuki , Asai Hideki , Abe Toshikazu , Amemiya Yu , Ishizawa Ryo , Ishihara Tadashi , Ishimaru Tadayoshi , Itosu Yusuke , Inoue Hiroyasu , Imahase Hisashi , Imura Haruki , Iwasaki Naoya , Ushio Noritaka , Uchida Masatoshi , Uchi Michiko , Umegaki Takeshi , Umemura Yutaka , Endo Akira , Oi Marina , Ouchi Akira , Osawa Itsuki , Oshima Yoshiyasu , Ota Kohei , Ohno Takanori , Okada Yohei , Okano Hiromu , Ogawa Yoshihito , Kashiura Masahiro , Kasugai Daisuke , Kano Ken‐ichi , Kamidani Ryo , Kawauchi Akira , Kawakami Sadatoshi , Kawakami Daisuke , Kawamura Yusuke , Kandori Kenji , Kishihara Yuki , Kimura Sho , Kubo Kenji , Kuribara Tomoki , Koami Hiroyuki , Koba Shigeru , Sato Takehito , Sato Ren , Sawada Yusuke , Shida Haruka , Shimada Tadanaga , Shimizu Motohiro , Shimizu Kazushige , Shiraishi Takuto , Shinkai Toru , Tampo Akihito , Sugiura Gaku , Sugimoto Kensuke , Sugimoto Hiroshi , Suhara Tomohiro , Sekino Motohiro , Sonota Kenji , Taito Mahoko , Takahashi Nozomi , Takeshita Jun , Takeda Chikashi , Tatsuno Junko , Tanaka Aiko , Tani Masanori , Tanikawa Atsushi , Chen Hao , Tsuchida Takumi , Tsutsumi Yusuke , Tsunemitsu Takefumi , Deguchi Ryo , Tetsuhara Kenichi , Terayama Takero , Togami Yuki , Totoki Takaaki , Tomoda Yoshinori , Nakao Shunichiro , Nagasawa Hiroki , Nakatani Yasuhisa , Nakanishi Nobuto , Nishioka Norihiro , Nishikimi Mitsuaki , Noguchi Satoko , Nonami Suguru , Nomura Osamu , Hashimoto Katsuhiko , Hatakeyama Junji , Hamai Yasutaka , Hikone Mayu , Hisamune Ryo , Hirose Tomoya , Fuke Ryota , Fujii Ryo , Fujie Naoki , Fujinaga Jun , Fujinami Yoshihisa , Fujiwara Sho , Funakoshi Hiraku , Homma Koichiro , Makino Yuto , Matsuura Hiroshi , Matsuoka Ayaka , Matsuoka Tadashi , Matsumura Yosuke , Mizuno Akito , Miyamoto Sohma , Miyoshi Yukari , Murata Satoshi , Murata Teppei , Yakushiji Hiromasa , Yasuo Shunsuke , Yamada Kohei , Yamada Hiroyuki , Yamamoto Ryo , Yamamoto Ryohei , Yumoto Tetsuya , Yoshida Yuji , Yoshihiro Shodai , Yoshimura Satoshi , Yoshimura Jumpei , Yonekura Hiroshi , Wakabayashi Yuki , Wada Takeshi , Watanabe Shinichi , Ijiri Atsuhiro , Ugata Kei , Uda Shuji , Onodera Ryuta , Takahashi Masaki , Nakajima Satoshi , Honda Junta , Matsumoto Tsuguhiro 
Published: February 2025

AbstractThe 2024 revised edition of the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock (J‐SSCG 2024) is published by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine. This is the fourth revision since the first edition was published in 2012. The purpose of the guidelines is to assist healthcare providers in making appropriate decisions in the treatment of sepsis and septic shock, leading to improved patient outcomes. We aimed to create guidelines that are easy to understand and use for physicians who recognize sepsis and provide initial management, specialized physicians who take over the treatment, and multidisciplinary healthcare providers, including nurses, physical therapists, clinical engineers, and pharmacists. The J‐SSCG 2024 covers the following nine areas: diagnosis of sepsis and source control, antimicrobial therapy, initial resuscitation, blood purification, disseminated intravascular coagulation, adjunctive therapy, post‐intensive care syndrome, patient and family care, and pediatrics. In these areas, we extracted 78 important clinical issues. The GRADE (Grading of Recommendations Assessment, Development and Evaluation) method was adopted for making recommendations, and the modified Delphi method was used to determine recommendations by voting from all committee members. As a result, 42 GRADE‐based recommendations, 7 good practice statements, and 22 information‐to‐background questions were created as responses to clinical questions. We also described 12 future research questions.