bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Reign of Constantine V in the Miracles of St. Theodore the Recruit (BHG 1764)
Authors: Zuckerman Constantin 
Published: January 2011

REB 46 1988 France p. 191-210
C. Zuckerman, The Reign of Constantine V in the Miracles of St. Theodore the Recruit (BHG 1 764). — One of St. Theodore the Recruit's miracles in his anonymous enkomion BHG 1764 is an eye-witness account of an Arab raid dated « in the fourteenth year of the God-protected and Christ-loving reign of Constantine, (...) at the beginning of the seventh indiction. » The present study suggests that in spite of the pious epithets, the emperor in question is Constantine V, the only Constantine whose fourteenth year overlapped a seventh indiction. The study presents the historical background of the raid — dated in 753/4 — and analyzes the ideological stand of the author of the enkomion, a closet icon-worshipper who used St. Theodore's miracles to state the orthodox position on all major planks of the iconoclast controversy. In the Appendix, miracles # 2 and # 3 are related to events from Heraclius' first Persian campaign of 622, which permits to take a fresh look at the geographical setting and the chronology of the campaign.
« Latter-day » Saints in the Model for the London and Barberini Psalters
Authors: Walter Christopher 
Published: January 2011

REB 46 1988 France p. 21 1-228, 8 pl.
Ch. Walter, « Latter-day » Saints in the Model for the London and Barberini Psalters. — The programme of the lost marginal psalter which served as a model for extant eleventh-century psalters is reconstructed. It is shown that it differed markedly from that of ninth-century psalters. It was built up round the theme of the just man and his assiduity in prayer. A repertory is then established of the miniatures of « latter-day » saints who exemplify the just man. The sources of this repertory are investigated. The debt of the Barberini and London Psalters to the lost model is then discussed. While the former followed the lost model faithfully, the latter modified it slightly, firstly by increasing the number of « latter day » saints who exemplify the overriding theme of the just man, and secondly by introducing a few new miniatures, which express the politico-religious ethos of the Studite monastery.
La tradition manuscrite de l'Histoire de Georges Pachymérès (livres VII-XIII)
Authors: Failler Albert 
Published: January 2011

REB 47 1989 France p. 91-181
A. Failler, La tradition manuscrite de l'Histoire de Georges Pachymérès (livres VII- XIII). — La seconde partie de l'Histoire de Georges Pachymérès est conservée, comme la première partie (voir BEB 37, 1979, p. 123-220), dans trois manuscrits indépendants (Monac. gr. 442, Barberin. gr. 199 et 204), qui datent du troisième quart du 14e siècle et qui sont donc postérieurs d'un demi-siècle à la rédaction de l'ouvrage. La tradition manuscrite est identique pour les deux parties, mais les problèmes d'établissement du texte sont différents ; c'est pourquoi les deux parties ont été traitées séparément. L'étude comprend six chapitres : L'état des manuscrits-sources (description et date), Les rapports. entre les manuscrits-sources (l'examen des copies montrant, comme pour la première partie, la supériorité du troisième des manuscrits cités), La version abrégée de l'Histoire, Les apographes des manuscrits-sources, L'édition de l'Histoire et le problème des titres, Les cinq actes patriarcaux transmis par une tradition distincte.
The Iconography of the Prophet Habakkuk
Authors: Walter Christopher 
Published: January 2011

REB 47 1989 France p. 251-260, 8 pl.
Ch. Walter, The Iconography of the Prophet Habakkuk. — The development of the iconography of Habakkuk is traced from its beginnings as an adjunct to that of Daniel in the lions' den through the illustration of his Ode in Psalters and of the Easter Homily of Gregory of Nazianzus to the Palaeologan version of the Latomos Miracle. An explanation is proposed of the prophet's characteristic twisted position in many of his later portraits.
Kontamination in der Athanasius-Überlieferung
Authors: Metzler Karin 
Published: January 2011

REB 48 1990 France p. 213-232
Karin Metzler, Kontamination in der Athanasius-Überlieferung. — Im Codex Patmiacus 4 ist ein Konjektur- Vorgang aus dem 11. Jh. direkt abzulesen, der das Vorgehen eines mittelalterlichen Philologen bei der Kontamination zeigt. Die aus einer anderen Handschriften-Tradition entnommenen Lesarten werden je nach ihrer Überzeugungskraft in den laufenden Text hineingebessert oder (seltener) mit dem Hinweis γρ(άφεται,) am Rand zur Diskussion gestellt. In der Abschrift im Codex Patmiacus 3 wird diese Differenzierung nur teilweise übernommen. — Nicht viel später ist ein anderer Kontaminations-Vorgang in der Athanasius-Überlieferung zu datieren, bei dem offenbar die meisten Lesarten der anderen Tradition und Konjekturen dem Leser und Abschreiber zur freien Auswahl gestellt werden.
Some unpublished lead seals concerning Crete
Authors: Tsougarakis Dimitris 
Published: January 2011

REB 48 1990 France p. 243-246, 1 pl.
D. Tsougarakis, Some unpublished lead seals concerning Crete. — The author publishes, with reproductions, five lead seals from the Dumbarton Oaks Collection, all concerning Crete and ranging from the 7th century to the 11th century.
Update on the aetiopathogenesis of canine cranial cruciate ligament disease
Authors: Smith K. , Hayashi K. , Comerford E. J. 
Published: January 2011

SummaryCranial cruciate ligament disease (CCLD) is the most common cause of hindlimb lameness in the dog, being associated with and eventually leading to stifle osteoarthritis. Canine cranial cruciate ligament disease is a gradual degeneration of the ligament extra-cellular matrix (ECM) leading to ligament rupture. The aetiopathogenesis of this condition is still poorly understood but several risk factors have been identified such as breed, bodyweight, gender and conformation. Recent developments in this area include the role of genetics, stifle joint conformation, ligament ECM metabolism, and inflammation associated with immune-mediated disease within the stifle joint. A genetic mode of inheritance has been demonstrated in the Newfoundland which is predisposed to CCLD. Increased cellular metabolism within the cranial cruciate ligament has been directly associated with increased craniocaudal stifle joint laxity in dog breeds at high risk of CCLD. Conformation abnormalities, such as a narrowed distal femoral intercondylar notch, in high risk breeds have been shown to be associated with alterations in cranial cruciate ligament ultrastructure. Increased production of inflammatory cytokines, such as cathepsins and interleukins, by the stifle synovial cells may occur secondary to or may be an inciting cause of ligament degeneration. Future research endeavours will focus on the association between immune-mediated response and fibrocartilaginous metaplasia and matrix degradation within the cranial cruciate ligament, and whether this can be altered in all susceptible dogs or only certain breeds.
Stifle synovial cyst in a Labrador Retriever with concurrent cranial cruciate ligament deficiency
Authors: Havlicek M. , Krockenberger M. B. , Franklin A. D. 
Published: January 2011

SummaryA seven-year-old Labrador Retriever dog was presented with the complaint of chronic left hindlimb lameness. A diagnosis of partial rupture of the left cranial cruciate ligament with concurrent cranio-medial synovial cyst formation was made. This cystic structure was assumed to be communicating with the stifle joint. There was no evidence of a meniscal tear, but superficial fibrillation of the axial border was present. Surgical excision of the cyst with concurrent treatment of the cranial cruciate ligament deficiency by tibial tuberosity advancement was performed with a successful outcome. Whilst commonly encountered in humans, synovial cysts are uncommon in dogs. To the authors’ knowledge this is the first reported case of synovial cyst formation in the stifle of a dog.
Haematogenous osteomyelitis: clinical presentation and outcome in three dogs
Authors: Rabillard M. , Souchu L. , Niebauer G. W. , Gauthier O. 
Published: January 2011

SummaryHaematogenous osteomyelitis is a rare form of bone infection in adult dogs. Most commonly the infection is iatrogenic or traumatic in origin. The authors report three different presentations of haematogenous osteomyelitis: a focal pelvic localisation in a growing dog, a vertebral lesion in an adult dog with associated neurological signs and a multifocal affection in another adult dog with concomitant pathological fractures.Clinical signs included pyrexia of undetermined origin, focal pain and lameness. Diagnostic investigation included radiographic imaging, bone scintigraphy, magnetic resonance imaging, surgical biopsy, and bacteriological culture with sensitivity testing of biopsy specimens as well as of peripheral blood samples. Treatment consisted of long-term antimicrobial therapy and surgical debridement with curettage of the pelvic abscess of the young dog and decompressive hemilaminectomy of the second dog, with excellent recovery. The dog affected by polyostotic bone involvement and suffering pathological fractures was euthanatized.Haematogenous osteomyelitis may be a diagnostic and therapeutic challenge and may present as a devastating skeletal condition, even in adult dogs, and should be considered amongst the differential diagnoses early on to allow effective treatment.
Phakic Intraocular Lens Implantation in United States Military Warfighters: A Retrospective Analysis of Early Clinical Outcomes of the Visian ICL
Authors: Parkhurst Gregory D. , Psolka Maximilian , Kezirian Guy M. 
Published: January 2011

PURPOSE:
To assess short-term clinical outcomes after implantation of phakic intraocular lenses (Visian ICL, STAAR Surgical Co) in US military warfighters who are not good candidates for laser vision correction.

METHODS:
A retrospective interventional consecutive case series analysis of all eyes that underwent ICL surgery during a 14-month time period was performed. Main outcome measures included indications for surgery, efficacy, predictability, and early adverse events.

RESULTS:
Three-month postoperative visual data were available for 135 eyes of 69 patients who underwent ICL implantation during the study period. Indications included abnormal corneal topography (37%), thin predicted residual bed following LASIK (32%), history of dry eye (13%), thin corneal thickness (11%), or other (7%). Mean patient age was 30.9±6.6 years. Mean preoperative spherical equivalent refraction was −6.00±1.92 diopters (D) (range: −2.63 to −11.50 D). Three months postoperative, uncorrected distance visual acuity of 20/20 or better was found in 129/135 (96%) eyes and 91/135 (67%) were 20/15 or better. Manifest refraction and corrected distance visual acuity (CDVA) data were available for 128 eyes. Forty-two (33%) eyes had improvement of one or more lines of CDVA. One hundred fifteen eyes (90%) were within ±0.50 D of emmetropia, and predictability within ±0.75 D was found in 127/128 (99%) eyes. No significant intra- or postoperative complications were observed.

CONCLUSIONS:
This retrospective analysis of 3-month outcomes suggests that Visian ICL implantation in myopic warfighters provides excellent refractive and visual results. Further study is needed to evaluate long-term results.
Meta-analysis of Clinical Outcomes Comparing Surface Ablation for Correction of Myopia With and Without 0.02% Mitomycin C
Authors: Chen Shi-hao , Feng Yi-fan , Stojanovic Aleksandar , Wang Qin-mei 
Published: January 2011

PURPOSE:
To evaluate the current clinical evidence of safety and efficacy of intraoperative topical application of 0.02% mitomycin C (MMC) used for up to 2 minutes after surface ablation for correction of myopia.

METHODS:
A comprehensive literature search was conducted of Cochrane Library, MEDLINE, and EMBASE to identify relevant trials comparing surface ablation for correction of myopia with and without MMC. A meta-analysis was performed on the results of the reports and statistical analysis was performed.

RESULTS:
Eleven clinical trials were identified with MMC used in 534 eyes and no MMC in 726 eyes. Surface ablations with MMC led to significantly less corneal haze in photorefractive keratectomy, whereas the results were comparable in laser epithelial keratomileusis (LASEK) and epithelial laser in situ keratomileusis (epi-LASIK). Although proportionately more eyes in the MMC group achieved uncorrected distance visual acuity 20/25 or better and less frequently lost ≥2 lines of corrected distance visual acuity, the difference was not statistically significant.

CONCLUSIONS:
Our meta-analysis suggests that the topical intraoperative application of 0.02% MMC may reduce haze and improve visual acuity after surface ablation for correction of myopia. However, the advantage of using MMC in LASEK and epi-LASIK is unclear.
A Method for Culturing Mussels Using In-River Cages
Authors: Brady Tony R. , Aloisi Doug , Gordon Roger , Wege Gary 
Published: January 2011

Abstract
A variety of techniques have been used since the early 1900s to produce mussels for augmenting depleted populations, including the use of wire-covered crates to house fish bearing mussel larvae. Here we describe a modification of earlier techniques, which provides a viable, low-cost method for producing large numbers of mussels. Aluminum-framed cages covered with commercially available hardware cloth are used to confine glochidia-bearing fish. Juvenile mussels then excyst off the host fish, and fall to the substrate-covered cage bottom, which protects the mussels from predation until they mature into subadult mussels. To date, seven species of mussels totaling over 57,100 2- and 3-y-old mussels have been reared in these culture cages.
Regulatory T Cell Properties of Chicken CD4+CD25+ Cells
Authors: Shanmugasundaram Revathi , Selvaraj Ramesh K. 
Published: January 2011

Abstract
Chicken CD4+CD25+ cells were characterized for mammalian regulatory T cells’ suppressive and cytokine production properties. Anti-chicken CD25 mAb was produced in mice and conjugated with a fluorescent tag. The specificity of the Ab against chicken CD25 was confirmed by evaluating Con A-induced CD25 upregulation in thymocytes and by quantifying the CD25 mRNA content of positive and negative cells identified by anti-chicken CD25 Ab. The percentage of CD4+CD25+ cells, expressed as a percentage of CD4+ cells, in thymus and blood was ∼3–7%, in spleen was 10%, and in cecal tonsil, lung, and bone marrow was ∼15%. Bursa had no detectable CD4+CD25+ cells. CD25+ cells were mostly CD4+ in the thymus, whereas in every other organ studied, CD25+ cells were distributed between CD4+ and CD4− cells. Chicken thymic CD4+CD25+ cells did not proliferate in vitro in the absence of recombinant chicken IL-2 (rCIL-2). In the presence of rCIL-2, PMA plus ionomycin or Con A stimulated CD4+CD25+ cell proliferation, whereas anti-CD3 plus CD28 did not stimulate CD4+CD25+ cell proliferation. Naive CD4+CD25+ cells had 29-fold more IL-10 mRNA and 15-fold more TGF-β mRNA than the naive CD4+CD25− cells. Naive CD4+CD25+ had no detectable IL-2 mRNA. Both naive and PMA plus ionomycin-stimulated thymic CD4+CD25+ cells suppressed naive T cell proliferation. The suppressive properties were partially contact dependent. Supplementing CD4+CD25+ cell coculture with rCIL-2 reversed the suppressive properties of CD4+CD25+ cells. Chicken CD4+CD25+ cells have suppressive properties similar to that of mammalian regulatory T cells.
TLR3-Specific Double-Stranded RNA Oligonucleotide Adjuvants Induce Dendritic Cell Cross-Presentation, CTL Responses, and Antiviral Protection
Authors: Jelinek Ivett , Leonard Joshua N. , Price Graeme E. , Brown Kevin N. , Meyer-Manlapat Anna , Goldsmith Paul K. , Wang Yan , Venzon David , Epstein Suzanne L. , Segal David M. 
Published: January 2011

Abstract
Maturation of dendritic cells (DC) to competent APC is essential for the generation of acquired immunity and is a major function of adjuvants. dsRNA, a molecular signature of viral infection, drives DC maturation by activating TLR3, but the size of dsRNA required to activate DC and the expression patterns of TLR3 protein in DC subsets have not been established. In this article, we show that cross-priming CD8α+ and CD103+ DC subsets express much greater levels of TLR3 than other DC. In resting DC, TLR3 is located in early endosomes and other intracellular compartments but migrates to LAMP1+ endosomes on stimulation with a TLR3 ligand. Using homogeneous dsRNA oligonucleotides (ONs) ranging in length from 25 to 540 bp, we observed that a minimum length of ∼90 bp was sufficient to induce CD86, IL-12p40, IFN-β, TNF-α, and IL-6 expression, and to mature DC into APC that cross-presented exogenous Ags to CD8+ T cells. TLR3 was essential for activation of DC by dsRNA ONs, and the potency of activation increased with dsRNA length and varied between DC subsets. In vivo, dsRNA ONs, in a size-dependent manner, served as adjuvants for the generation of Ag-specific CTL and for inducing protection against lethal challenge with influenza virus when given with influenza nucleoprotein as an immunogen. These results provide the basis for the development of TLR3-specific adjuvants capable of inducing immune responses tailored for viral pathogens.
Polypyrimidine Tract-Binding Protein Is Critical for the Turnover and Subcellular Distribution of CD40 Ligand mRNA in CD4+ T Cells
Authors: Matus-Nicodemos Rodrigo , Vavassori Stefano , Castro-Faix Moraima , Valentin-Acevedo Anibal , Singh Karnail , Marcelli Valentina , Covey Lori R. 
Published: January 2011

Abstract
CD40L (CD154) is regulated at the posttranscriptional level by an activation-induced process that results in a highly stable transcript at extended times of T cell activation. Transcript stability is mediated by polypyrimidine tract-binding protein (PTB)-containing complexes (complex I and II) that bind to three adjacent CU-rich sequences within the 3′ untranslated region. To assess the role of PTB in the expression and distribution of CD40L mRNA, PTB was targeted using short hairpin RNA in both primary T cells and a T cell line that recapitulates the stability phase of regulated CD40L mRNA decay. PTB knockdown resulted in a marked decrease in the mRNA stability that resulted in lowered CD40L surface expression. PTB was also critical for appropriate distribution of CD40L mRNA between the nucleus and cytoplasm and in the cytoplasm between the cytosol and the translating polysomes. The activation-induced formation of PTB-specific ribonucleoprotein complexes was observed only with cytoplasmic and not nuclear PTB indicating functional differences in the protein defined by cellular localization. Finally, we observed that cytoplasmic and nuclear PTB isoforms were differentially modified relative to each other and that the changes in cytoplasmic PTB were consistent with activation-induced phosphorylation. Together this work suggests that differentially modified PTB regulates CD40L expression at multiple steps by 1) retaining CD40L mRNA in the nucleus, 2) directly regulating mRNA stability at late times of activation, and 3) forming a ribonuclear complex that preferentially associates with translating ribosomes thus leading to an enhanced level of CD40L protein.
Standard versus Bolus Photodynamic Therapy in Circumscribed Choroidal Hemangioma: Functional Outcomes
Authors: Pilotto Elisabetta , Urban Francesca , Parrozzani Raffaele , Midena Edoardo 
Published: January 2011

Purpose TO compare standard versus bolus photodynamic therapy (PDT) in the treatment of symptomatic circumscribed choroidal hemangioma (CCH). Methods Twenty consecutive cases of CCH were included in this prospective randomized study. Each patient was randomly assigned to receive either standard PDT (10-minute 6 mg/mq2 verteporfin infusion; treatment at 15 min; 50 J/cm2; 83 s) or bolus PDT (6 mg/mq2 verteporfin infusion bolus in 1 min; treatment at 5 min; 100 J/cm2; 166 s). Best-corrected visual acuity (BCVA), fundus photography, optical coherence tomography, fluorescein, and indocyanine green angiography were performed at baseline and during follow-up. Retinal sensitivity was tested with microperimetry before and after treatment. Follow-up was longer than 32 months. Results Mean follow-up was 58±11 months. All cases (100%) showed clinical regression of the treated lesion. Neuroretinal and retinal pigment epithelium (RPE) changes were found in 9 (90%) bolus PDT over treated area. No similar RPE changes were found in patients treated with standard PDT. There was a no statistically significant difference in BCVA outcome between the 2 groups (p=0.078). Microperimetry revealed reduced sensitivity over the treated area in 7 bolus PDT vs 1 in standard treated eyes (p=0.008). Conclusions Both standard and bolus PDT induce regression of symptomatic CCH. Bolus PDT may cause RPE and retinal changes associated with reduced retinal sensitivity.
Label‐Free Assessment of Key Biological Autofluorophores: Material Characteristics and Opportunities for Clinical Applications
Authors: Campbell Jared M. , Gosnell Martin , Agha Adnan , Handley Shannon , Knab Aline , Anwer Ayad G. , Bhargava Akanksha , Goldys Ewa M. 
Published: May 2024

AbstractAutofluorophores are endogenous fluorescent compounds that naturally occur in the intra and extracellular spaces of all tissues and organs. Most have vital biological functions – like the metabolic cofactors NAD(P)H and FAD+, as well as the structural protein collagen. Others are considered to be waste products – like lipofuscin and advanced glycation end products – which accumulate with age and are associated with cellular dysfunction. Due to their natural fluorescence, these materials have great utility for enabling non‐invasive, label‐free assays with direct ties to biological function. Numerous technologies, with different advantages and drawbacks, are applied to their assessment, including fluorescence lifetime imaging microscopy, hyperspectral microscopy, and flow cytometry. Here, the applications of label‐free autofluorophore assessment are reviewed for clinical and health‐research applications, with specific attention to biomaterials, disease detection, surgical guidance, treatment monitoring, and tissue assessment – fields that greatly benefit from non‐invasive methodologies capable of continuous, in vivo characterization.
The Spermine Oxidase/Spermine Axis Coordinates ATG5‐Mediated Autophagy to Orchestrate Renal Senescence and Fibrosis
Authors: Luo Dan , Lu Xiaohui , Li Hongyu , Li Yi , Wang Yating , Jiang Simin , Li Guanglan , Xu Yiping , Wu Kefei , Dou Xianrui , Liu Qinghua , Chen Wei , Zhou Yi , Mao Haiping 
Published: May 2024

AbstractDecreased plasma spermine levels are associated with kidney dysfunction. However, the role of spermine in kidney disease remains largely unknown. Herein, it is demonstrated that spermine oxidase (SMOX), a key enzyme governing polyamine metabolism, is predominantly induced in tubular epithelium of human and mouse fibrotic kidneys, alongside a reduction in renal spermine content in mice. Moreover, renal SMOX expression is positively correlated with kidney fibrosis and function decline in patients with chronic kidney disease. Importantly, supplementation with exogenous spermine or genetically deficient SMOX markedly improves autophagy, reduces senescence, and attenuates fibrosis in mouse kidneys. Further, downregulation of ATG5, a critical component of autophagy, in tubular epithelial cells enhances SMOX expression and reduces spermine in TGF‐β1‐induced fibrogenesis in vitro and kidney fibrosis in vivo. Mechanically, ATG5 readily interacts with SMOX under physiological conditions and in TGF‐β1‐induced fibrogenic responses to preserve cellular spermine levels. Collectively, the findings suggest SMOX/spermine axis is a potential novel therapy to antagonize renal fibrosis, possibly by coordinating autophagy and suppressing senescence.