bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parallel heterogeneous CBIR system for efficient hyperspectral image retrieval using spectral mixture analysis
Authors: Plaza Antonio J. , Plaza Javier , Paz Abel 
Published: December 2009

AbstractThe purpose of content‐based image retrieval (CBIR) is to retrieve, from real data stored in a database, information that is relevant to a query. In remote sensing applications, the wealth of spectral information provided by latest‐generation (hyperspectral) instruments has quickly introduced the need for parallel CBIR systems able to effectively retrieve features of interest from ever‐growing data archives. To address this need, this paper develops a new parallel CBIR system that has been specifically designed to be run on heterogeneous networks of computers (HNOCs). These platforms have soon become a standard computing architecture in remote sensing missions due to the distributed nature of data repositories. The proposed heterogeneous system first extracts an image feature vector able to characterize image content with sub‐pixel precision using spectral mixture analysis concepts, and then uses the obtained feature as a search reference. The system is validated using a complex hyperspectral image database, and implemented on several networks of workstations and a Beowulf cluster at NASA's Goddard Space Flight Center. Our experimental results indicate that the proposed parallel system can efficiently retrieve hyperspectral images from complex image databases by efficiently adapting to the underlying parallel platform on which it is run, regardless of the heterogeneity in the compute nodes and communication links that form such parallel platform. Copyright © 2009 John Wiley & Sons, Ltd.
An inventory and update of jealousy‐evoking partner behaviours in modern society
Authors: Dijkstra Pieternel , Barelds Dick P. H. , Groothof Hinke A. K. 
Published: December 2009

AbstractThe goal of the present study was to identify the most important jealousy‐evoking partner behaviours and to examine the extent to which these behaviours evoke jealousy. Based on the literature, a questionnaire was constructed containing 42 jealousy‐evoking partner behaviours, including a partner's extra‐dyadic involvement with someone else by means of modern communication devices, such as the Internet. A second study examined the extent to which undergraduates and a community sample experienced jealousy in response to these partner behaviours. Results showed that explicit unfaithful behaviours evoked most feelings of jealousy, followed by a partner's emotional or romantic involvement with someone else by means of modern communication devices. In general, older individuals responded with less jealousy in response to a partner's unfaithful and suspicious behaviours. Clinical implications are discussed. Copyright © 2009 John Wiley & Sons, Ltd.
Key Practitioner Message:

A partner's involvement with someone else by means of modern communication devices may evoke strong feelings of jealousy, in particular among women.
An individual's age affects the extent to which he or she experiences jealousy in response to specific extra‐dyadic partner behaviours.
In order to correctly diagnose and treat pathological jealousy, clinicians should pay attention to the extent to which partners (unintentionally) evoke and maintain feelings of jealousy.
Identifying partner behaviours that evoke most jealousy may help couples define the boundaries of their relationship.
Next‐generation antimalarial drugs: hybrid molecules as a new strategy in drug design
Authors: Muregi Francis W. , Ishih Akira 
Published: December 2009

AbstractMalaria is a disease that affects nearly 40% of the global population, and chemotherapy remains the mainstay of its control strategy. The global malaria situation is increasingly being exacerbated by the emergence of drug resistance to most of the available antimalarials, necessitating search for novel drugs. A recent rational approach of antimalarial drug design characterized as “covalent bitherapy” involves linking two molecules with individual intrinsic activity into a single agent, thus packaging dual‐activity into a single hybrid molecule. Current research in this field seems to endorse hybrid molecules as the next‐generation antimalarial drugs. If the selective toxicity of hybrid prodrugs can be demonstrated in vivo with good bioavailability at the target site in the parasite, it would offer various advantages including dosage compliance, minimized toxicity, ability to design better drug combinations, and cheaper preclinical evaluation while achieving the ultimate object of delaying or circumventing the development of resistance. This review is focused on several hybrid molecules that have been developed, with particular emphasis on those deemed to have high potential for development for clinical use. Drug Dev Res 71: 20–32, 2010. © 2009 Wiley‐Liss, Inc.
Which drug is effective and safe for acute malaria in pregnancy? Reviewing the evidence
Authors: McGready Rose , Nosten François 
Published: December 2009

AbstractDuring pregnancy, a woman living or travelling in a malaria endemic area is more at risk of contracting the disease and developing a severe infection and dying than a non‐pregnant woman. Despite this increased morbidity and mortality in pregnancy, there are almost no studies on which to base recommendations on the use of antimalarial drugs in this vulnerable group. This is because, paradoxically, the emphasis is often put on the safety of the unborn child rather than that of the infested mother. As a result of this neglect, tens of thousands of pregnant women (and their fetuses) are dying every year of a very preventable and treatable infection. In recent years, some trials have been conducted, especially in areas of high resistance in Plasmodium falciparum in South East Asia. The results show that quinine plus clindamycin is the treatment of choice in the first trimester, while artemisinin treatment should be used in the second and third trimesters in the treatment of uncomplicated malaria. For severe malaria, parenteral artesunate is the treatment of choice. However these studies have also shown that the pharmacokinetic properties of most antimalarials are altered during gestation and that the doses used in non‐pregnant adults are often not adapted to pregnancy. Urgent efforts are required to optimize the treatment of malaria in pregnancy. Drug Dev Res 71:56–68, 2010. © 2009 Wiley‐Liss, Inc.
Gaining time: early treatment of severe pediatric malaria in Tanzania
Authors: Gomes M.F. , Warsame M. , Nasemba N. , Singlovic J. , Kapinga A. , Mwankuyse S. , Mduma S. , Msabaha M.H. , Mulokosi F. , Shishira J. , Kitua A. , Mrango Z. 
Published: December 2009

AbstractEarly effective treatment prevents death or disability from malaria. In malaria‐endemic rural areas, pediatric patients who cannot take drugs orally and require injectable treatment have to be transported to the nearest facility that can give injectable malaria drugs. If time to reach the hospital is long, pre‐referral treatment and effective referral can play a major positive role. We compare the clinical course of illness and time taken to reach hospital in patients from Study 13, a randomized controlled study of pre‐referral rectal artesunate in which rapid referral was emphasized, with a comparator group of pediatric patients admitted at the same hospital in Tanzania whose parents' actions prior to admission at the hospital reflected routine behavior. The key difference was that parents of sick children from the intervention study rapidly transferred their children to the hospital following the advice they were given. Time gained by the referral study was 48 h and this difference was reflected in less severe symptoms at admission. Efforts to improve referral advice in the community can be a powerful complement to other malaria case management strategies. Drug Dev Res 71: 92–98, 2010. © 2009 Wiley‐Liss, Inc.
Conception of self‐construction production scheduling system
Authors: Xue Hai , Zhang Xuerui , Shimizu Yasuhiro , Fujimura Shigeru 
Published: December 2009

AbstractWith the high speed innovation of information technology, many production scheduling systems have been developed. However, a lot of customization according to individual production environment is required, and then a large investment for development and maintenance is indispensable. Therefore now the direction to construct scheduling systems should be changed. The final objective of this research aims at developing a system which is built by it extracting the scheduling technique automatically through the daily production scheduling work, so that an investment will be reduced. This extraction mechanism should be applied for various production processes for interoperability. Using the master information extracted by the system, production scheduling operators can be supported to accelerate the production scheduling work easily and accurately without any restriction of scheduling operations. By installing this extraction mechanism, it is easy to introduce a scheduling system without a lot of expense for customization. In this paper, first a model for expressing a scheduling problem is proposed. Then the guideline to extract the scheduling information and use the extracted information is shown and some applied functions are also proposed based on it. © 2009 Wiley Periodicals, Inc. Electron Comm Jpn, 93(1): 19–29, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecj.10188
Nickel‐Catalyzed Solvent‐Free Three‐Component Coupling of Aldehyde, Alkyne and Amine
Authors: Namitharan Kayambu , Pitchumani Kasi 
Published: December 2009

AbstractA versatile three‐component coupling of aldehydes, alkynes and amines has been developed, catalyzed by Ni2+‐exchanged Y‐zeolite, which acts as an environmentally benign, recyclable, efficient and heterogeneous catalyst. This three‐component (A3) coupling (reported for the first time to proceed under nickel catalysis) is carried out under solvent‐free conditions, and the corresponding propargylamines are obtained in good to excellent yields.
Statistical inference for food webs with emphasis on ecological networks via Bayesian melding
Authors: Chiu Grace S. , Gould Joshua M. 
Published: December 2009

AbstractQuantifying activities in a food web or ecological network, and related aspects of dependence, has largely been either descriptive or deterministic. Although schemes exist for assessing the reliability of such quantification, many are far from being statistical in nature. Statistical modeling approaches are explored, with a focus on the ecosystem aspects of a food web. By employing Bayesian melding, we provide a new statistical inferential approach for understanding ecological networks in the context of mass balance. Our approach embodies the traditional deterministic views on network relations, yet it is developed on the basis of proper statistical inference that allows the estimation of physical quantities and probabilistic assessment of the estimation. We describe our approach, and illustrate it with a mass balance dataset. The practical advantage of our approach is a more realistic understanding of the network by incorporating natural measurement variability into deterministic beliefs about the relationships among measurements. The resulting inference thus forms a more honest representation of the true state of nature, and provides a formal assessment of balance before data are passed on to later stages of an ecological network analysis (ENA). We also demonstrate that general Bayesian inference for ENA can yield new ecological insight that may not be available through standard classical inference. Copyright © 2009 John Wiley & Sons, Ltd.
Assessing the value of Hermite densities for predictive distributions
Authors: Mauleón Ignacio 
Published: December 2009

AbstractThe empirical behaviour of two Hermitian densities—the Edgeworth asymptotic expansion, and the Gallant and Nychka (1987) squared transformation—are assessed and compared to Hansen's (1994) asymmetric Studentt. The comparison focuses on VaR measurements and overall probability fits. In and out of sample, Berkowitz's (2001) extended procedures are also implemented. Results are moderately favourable to the Hermitians, supporting the semi‐nonparametric interpretation, and multivariate developments. Copyright © 2009 John Wiley & Sons, Ltd.
Lack of HLA class II antigen expression in microsatellite unstable colorectal carcinomas is caused by mutations in HLA class II regulatory genes
Authors: Michel Sara , Linnebacher Michael , Alcaniz Joshua , Voss Maike , Wagner Rudolf , Dippold Wolfgang , Becker Christina , von Knebel Doeberitz Magnus , Ferrone Soldano , Kloor Matthias 
Published: December 2009

AbstractColorectal cancers (CRCs) develop on the basis of a deficient DNA mismatch repair (MMR) system in about 15% of cases. MMR‐deficient CRC lesions show high‐level microsatellite instability (MSI‐H) and accumulate numerous mutations located at coding microsatellite loci that lead to the generation of immunogenic neopeptides. Consequently, the host's antitumoral immune response is of high importance for the course of the disease in MSI‐H CRC patients. Accordingly, immune evasion mediated by impairment of HLA class I antigen presentation is frequently observed in these cancers. In this study, we aimed at a systematic analysis of alterations affecting HLA class II antigen expression in MSI‐H CRC. HLA class II antigens are expressed by only two‐thirds of MSI‐H CRCs. The mechanisms underlying the lack of HLA class II antigens in a subset of MSI‐H CRCs remain unknown. We here screened HLA class II regulatory genes for the presence of coding microsatellites and identified mutations of the essential regulator genes RFX5 in 9 (26.9%) out of 34 and CIITA in 1 (2.9%) out of 34 MSI‐H CRCs. RFX5 mutations were related to lack of or faint HLA class II antigen expression (p = 0.006, Fisher's exact test). Transfection with wild‐type RFX5 was sufficient to restore interferon gamma‐inducible HLA class II antigen expression in the RFX5‐mutant cell line HDC108. We conclude that somatic mutations of the RFX5 gene represent a novel mechanism of loss of HLA class II antigen expression in tumor cells, potentially contributing to immune evasion in MSI‐H CRCs.
A novel role of gap junction connexin46 protein to protect breast tumors from hypoxia
Authors: Banerjee Debarshi , Gakhar Gunjan , Madgwick Dan , Hurt Amy , Takemoto Dolores , Nguyen Thu Annelise 
Published: December 2009

AbstractConnexin proteins are the principle structural components of the gap junctions. Colocalization and tissue‐specific expression of diverse connexin molecules are reported to occur in a variety of organs. Impairment of gap junctional intercellular communication, caused by mutations, gain of function or loss of function of connexins, is involved in a number of diseases including the development of cancer. Here we show that human breast cancer cells, MCF‐7 and breast tumor tissues express a novel gap junction protein, connexin46 (Cx46) and it plays a critical role in hypoxia. Previous studies have shown that connexin46 is predominantly expressed in lens and our studies find that Cx46 protects human lens epithelial cells from hypoxia induced death. Interestingly, we find that Cx46 is upregulated in MCF‐7 breast cancer cells and human breast cancer tumors. Downregulation of Cx46 by siRNA promotes 40% MCF‐7 cell death at 24 hr under hypoxic conditions. Furthermore, direct injection of anti‐Cx46 siRNA into xenograft tumors prevents tumor growth in nude mice. This finding will provide an exciting new direction for drug development for breast cancer treatment and suggests that both normal hypoxic tissue (lens) and adaptive hypoxic tissue (breast tumor) utilize the same protein, Cx46, as a protective strategy from hypoxia.
E2F‐1 RNomics is critical for reprogramming of cancer cells to quiescent state
Authors: Mehrotra Aanchal , Joshi Kusum , Kaul Deepak 
Published: December 2009

AbstractThe discovery of cooperativity between pRB and E2F greatly prompted various investigators to find how E2F biology contributes to oncogenesis. Although E2F family of transcription factors have been linked to proliferation, apoptosis and differentiation, yet no heed has been paid to understand the role of E2F biology in cellular quiescence. To understand the functional RNomics (regulation of gene transcription through RNA interference) of E2F‐1 gene, 2 cancer cell lines, such as Jurkat exhibiting E2F‐1 gene overamplification and Hela‐229 exhibiting intrinsic downregulation of E2F‐1 gene expression, were used in our study. E2F‐1 gene knockdown via siRNA within Jurkat cells resulted in upregulation of genes characteristic of quiescence both translationally and transcriptionally, which was accompanied by downregulation of genes at both translational and transcriptional level involved in cell cycle progression and apoptosis. This genomic phenomenon also translated into ultrastructural and phenotypic features typical of quiescent state. These observed results in Jurkat cells were simulated by upregulation of E2F‐1 gene in Hela‐229 cells through the downregulation of miR 17‐5p. This E2F‐1‐regulated pathway explained as to how Jurkat cells entered exclusively into quiescent state when E2F‐1 was downregulated in these cells and how Hela‐229 cells proliferate vigorously when E2F‐1 was upregulated in such cells. Here, we propose a gene‐regulatory pathway which the cell might be using in its entry into either quiescent or proliferative states. Furthermore, this pathway may be useful in designing strategies for the treatment of cancer in general and acute lymphoblastic leukemia in particular.
Antitumorigenic effects of a mutant of the heparin affin regulatory peptide on the U87 MG glioblastoma cell line
Authors: Santos Célia Dos , Karaky Racha , Renoir Dominique , Hamma‐Kourbali Yamina , Albanese Patricia , Gobbo Emilie , Griscelli Frank , Opolon Paule , Dalle Sophie , Perricaudet Michel , Courty José , Delbé Jean 
Published: December 2009

AbstractGlioblastoma is the most common primary brain tumor in human adults. Since existing treatments are not effective enough, novel therapeutic targets must be sought. The heparin‐binding growth factor, heparin affin regulatory peptide (HARP), also known as pleiotrophin (PTN), could potentially represent such a target. We have previously shown that a mutant protein, HARPΔ111–136, which lacks HARP's C‐terminal 26 amino acids, acts as a dominant negative HARP effector by heterodimerizing with the wild‐type growth factor. The aim of our study was to evaluate the potential inhibitory activity of HARPΔ111–136 on the U87 MG human glioblastoma cell line. By overexpressing the truncated form of HARP in stably established clones of U87 MG cells, we observed an inhibition of proliferation under both anchorage‐dependent and anchorage‐independent conditions. We confirmed these results in an in vivo subcutaneous tumor xenograft model. In addition, we found that HARPΔ111–136 inhibited cell proliferation in a paracrine manner. Analysis of key cellular pathways revealed a decrease of cell adhesion in U87 MG cells that overexpressed the mutant protein, which could explain this inhibitory effect. A replication‐defective adenovirus model that encoded HARPΔ111–136 supported a putative antiproliferative role for the truncated protein in vitro and in vivo. Interestingly, HARPΔ111–136 was also able to abolish angiogenic activity in HUVEC proliferation and in a Matrigel plug assay. These results demonstrate that considering its antiproliferative and angiostatic effects, HARPΔ111–136 could be of great interest when used in conjunction with standard treatments.
Anti‐inflammatory M2 type macrophages characterize metastasized and tyrosine kinase inhibitor‐treated gastrointestinal stromal tumors
Authors: van Dongen Minka , Savage Nigel D.L. , Jordanova Ekaterina S. , Briaire‐de Bruijn Inge H. , Walburg Kimberley V. , Ottenhoff Tom H.M. , Hogendoorn Pancras C.W. , van der Burg Sjoerd H. , Gelderblom Hans , van Hall Thorbald 
Published: December 2009

AbstractWe have made a detailed inventory of the immune infiltrate of gastrointestinal stromal tumors (GISTs), which originate from mesenchymal cells in the intestinal tract. These sarcomas are heavily infiltrated with macrophages and T cells, while immune cells of other lineages were much less abundant. Dissecting the functional subtypes of T cells with multicolor fluorescent microscopy revealed substantial populations of cytotoxic T cells, helper T cells and FoxP3+ regulatory T cells. The balance of cytotoxic T cells and FoxP3+ T cells was toward immune suppression. Analysis of the macrophage population also showed a dominance of anti‐inflammatory cells, as the M2 type scavenger receptor CD163 was abundantly present. Other subsets of macrophages (CD14+CD163−) were occasionally detected. M2 type CD163+ macrophages were associated with the number of infiltrating FoxP3+ regulatory T cells and twice as many macrophages were found in metastatic GIST compared to primary lesions. Most metastatic GISTs had been treated with the tyrosine kinase inhibitors imatinib and sunitinib, but the high macrophage infiltrate was not related to this treatment. However, imatinib and sunitinib did induce secretion of anti‐inflammatory IL‐10 in macrophage cultures, indicating that treatment with these inhibitors might contribute to an immune suppressive microenvironment in GIST. Overall, our data reveal a picture of GIST as an active site of tumor‐immune interaction in which suppressive mechanisms overrule potential antitumor responses. Tyrosine kinase inhibitors might promote this negative balance.
Endomyocardial biopsy derived adherent proliferating cells—A potential cell source for cardiac tissue engineering
Authors: Haag Marion , Van Linthout Sophie , Schröder Sebastian E.A. , Freymann Undine , Ringe Jochen , Tschöpe Carsten , Sittinger Michael 
Published: December 2009

AbstractHeart diseases are a leading cause of morbidity and mortality. Cardiac stem cells (CSC) are considered as candidates for cardiac‐directed cell therapies. However, clinical translation is hampered since their isolation and expansion is complex. We describe a population of human cardiac derived adherent proliferating (CAP) cells that can be reliably and efficiently isolated and expanded from endomyocardial biopsies (0.1 cm3). Growth kinetics revealed a mean cell doubling time of 49.9 h and a high number of 2.54 × 107 cells in passage 3. Microarray analysis directed at investigating the gene expression profile of human CAP cells demonstrated the absence of the hematopoietic cell markers CD34 and CD45, and of CD90, which is expressed on mesenchymal stem cells (MSC) and fibroblasts. These data were confirmed by flow cytometry analysis. CAP cells could not be differentiated into adipocytes, osteoblasts, chondrocytes, or myoblasts, demonstrating the absence of multilineage potential. Moreover, despite the expression of heart muscle markers like α‐sarcomeric actin and cardiac myosin, CAP cells cannot be differentiated into cardiomyocytes. Regarding functionality, CAP cells were especially positive for many genes involved in angiogenesis like angiopoietin‐1, VEGF, KDR, and neuropilins. Globally, principal component and hierarchical clustering analysis and comparison with microarray data from many undifferentiated and differentiated reference cell types, revealed a unique identity of CAP cells. In conclusion, we have identified a unique cardiac tissue derived cell type that can be isolated and expanded from endomyocardial biopsies and which presents a potential cell source for cardiac repair. Results indicate that these cells rather support angiogenesis than cardiomyocyte differentiation. J. Cell. Biochem. 109: 564–575, 2010. © 2009 Wiley‐Liss, Inc.