bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perforation of the sinus of Valsalva by guiding catheter during the percutaneous coronary intervention via the right transradial approach: A very unusual complication
Authors: Tomassini Francesco , Gagnor Andrea , Varbella Ferdinando 
Published: April 2011

AbstractIatrogenic dissection of the sinus of Valsalva or of the ascending aorta is a rare but potentially fatal event, during the percuteneous coronary intervention (PCI). We reported a case of perforation of the sinus of Valsalva by guiding catheter during PCI via the right transradial approach (TRA) successfully managed and sealed without any sequelae. The choice of guiding catheter into the right TRA should be done carefully and its manipulation should be performed with caution in the coronary artery and in the sinus of Valsalva. © 2011 Wiley Periodicals, Inc.
Characterization of radiation exposure and effect of a radiation monitoring policy in a large volume pediatric cardiac catheterization lab
Authors: Verghese George R. , McElhinney Doff B. , Strauss Keith J. , Bergersen Lisa 
Published: April 2011

AbstractObjectives: This study aimed to characterize radiation dose during cardiac catheterization in congenital heart disease and to assess changes in dose after the introduction of a radiation monitoring policy. Background: Minimizing radiation exposure is an important patient safety initiative and relatively few data are available characterizing radiation dose for the broad spectrum of congenital cardiac catheter‐based interventions. Methods: Radiation dose data were reviewed on all cases since 7/1/05 at a single large center. Procedures were classified according to 20 common case types then subdivided into five age categories. Groups with <20 cases were excluded. Radiation dose was estimated by cumulative air KERMA (mGy) and DAP (dose area product, μGym2) which were reported as median and interquartile range (IQR). We also examined differences in radiation dose before and after the implementation of a radiation policy. Results: Between 7/1/05 and 12/10/08, 3,365 cases were identified for inclusion. Radiation dose increased with age and procedural complexity. Patients were characterized into low, medium, and high dose categories relative to each other. “Low” dose cases included isolated pulmonary or aortic valvotomy, pre‐Fontan assessment, and ASD closure. “High” dose cases involved multiple procedures in pulmonary arteries or veins. After introduction of a radiation policy, there was a significant decrease in radiation dose across a variety of case types, particularly among infants and young children. Conclusions: Radiation dose in congenital cardiac catheterization varies by age and procedure type. A radiation monitoring and notification policy may have contributed to reduced radiation dose. © 2011 Wiley Periodicals, Inc.
Percutaneous transcatheter closure of interatrial septal defect in adults: Procedural outcome and long‐term results
Authors: Kefer Joelle , Sluysmans Thierry , Hermans Cedric , Khoury Rames El , Lambert Catherine , Van de Wyngaert Françoise , Ovaert Caroline , Pasquet Agnes 
Published: April 2011

AbstractBackground: Percutaneous transcatheter closure of patent foramen ovale (PFO) and atrial septal defect (ASD) has been shown to be feasible. Aim: The aim of this study was to evaluate the safety and efficacy of transcatheter interatrial septal shunt closure with prosthesis implantation in adults patients during long‐term follow‐up. In addition, the impact of thrombophilia and pulmonary hypertension on the outcome were investigated. Methods: Between June 1999 and November 2009, 287 patients (112 males, 43 ± 14 years) were treated in our institution by transcatheter closure of PFO (N = 175) or ASD (N = 112). Clinical and echocardiographic follow‐up were prospectively performed at 1, 6 and 12 months followed by a 1 once a year evaluation. Results: All procedures were successful with eight procedural complications (2.7%): one stroke, two femoral pseudoaneurysms, three transient atrial fibrillation, two minors pericardial effusions. Among patients with presumed paradoxical embolism, thrombophilia was observed in 29 patients (17%); only one of them experienced a recurrent stroke. Among patients with ASD, pulmonary hypertension was observed in 32 cases (28%) and significantly reduced 6 months after shunt closure (from 47 ± 7 to 31 ± 11 mm Hg, P < 0.0001). 99% of patients achieved a complete follow‐up. Clinical improvement was observed in 93%. Freedom from death, cardiac surgery or recurrent embolism was 98 ± 1% at 5 years. Conclusion: Percutaneous transcatheter interatrial septal defect closure is a safe and effective treatment in adults patients, even in case of thrombophilia or pulmonary hypertension, during a long‐term follow‐up, up to 11 years. © 2011 Wiley Periodicals, Inc.
Rapid cycle change to predominantly radial access coronary angiography and percutaneous coronary intervention
Authors: Nadarasa Kugathasan , Robertson M. Clare , Wong Cheuk‐Kit , Green Belinda K.W. , Chen Victor H.T. , Wilkins Gerard T. , Williams Michael J.A. 
Published: April 2011

AbstractObjectives: This study sought to evaluate the safety and feasibility of all operators at a single center changing from predominantly femoral to radial access for coronary percutaneous procedures. Background: The radial artery is currently regarded as a useful vascular access site for coronary angiography and percutaneous coronary intervention (PCI). The reduction in local vascular access complications is thought to be a major advantage of the radial route. Despite this, the technique is used less frequently possibly reflecting concerns by cardiologists about the feasibility of using radial access as a preferred option. Methods: A retrospective study of 1004 consecutive patients who underwent coronary angiography with or without PCI was analyzed. Procedure details and clinical outcomes were assessed according to the radial or femoral approaches. Results: The success rate for cardiac catheterization via the radial approach was 97.4% (815/837) and the femoral approach was 98.8% (165/167). The procedural failure rate for radial access was not different from the femoral route [2.6% vs. 1.2%; odds ratio (OR), 2.26; 95% confidence interval (CI), 0.53–9.71; P = 0.41]. Major access site complications occurred in 0.25% patients in the radial group compared with 4.8% patients in the femoral group [OR, 0.05 (95% CI, 0.01–0.23); P < 0.0001]. Conclusions: The radial approach has a high rate of success and is associated with fewer major local vascular access site complications than the femoral route. These results can be achieved early in the operator learning curve of low to medium volume operators. © 2011 Wiley Periodicals, Inc.
Thrombus formation after left atrial appendage exclusion using an amplatzer cardiac plug device
Authors: Cruz‐Gonzalez Ignacio , Martín Moreiras Javier , García Eulogio 
Published: April 2011

AbstractThe feasibility and safety of left atrial appendage closure with the Amplatzer cardiac plug (AGA Medical Corp., Minneapolis, MN) have been recently published; no thrombus formation on the device surface has been reported previously. We describe a case of a 66‐year‐old man with permanent atrial fibrillation, previous stroke, and contraindication for long‐term oral anticoagulant therapy. A 22‐mm ACP device was deployed successfully without complications. The patient was discharged on acetyl salicylic acid 100 mg and clopidogrel 75 mg daily. After 4 weeks, the patient was admitted for a lower gastrointestinal bleeding and clopidogrel was stopped. A 3‐month follow‐up echocardiogram confirmed the exclusion of the LAA but it demonstrated the presence of a thrombus on the atrial surface of the device. It was decided to keep the patient on acetyl salicylic acid 100 mg with the addition of enoxaparin 60 mg bid. Transesophageal echocardiogram demonstrated total resolution of the thrombus after 2 months. © 2011 Wiley Periodicals, Inc.
Morphology and Crystal‐Plane Effects of Nanoscale Ceria on the Activity of CuO/CeO2 for NO Reduction by CO
Authors: Liu Lianjun , Yao Zhijian , Deng Yu , Gao Fei , Liu Bin , Dong Lin 
Published: April 2011

AbstractThe present work elucidated the morphology and crystal‐plane effects of nanoscale ceria on the activity of CuO/CeO2 catalysts toward NO reduction. CeO2 Nanopolyhedra were enclosed by (111) and (100) planes; the nanorods predominantly exposed (110) and (100) surfaces, and the nanocubes only showed the polar (100) planes. Moreover, the strongest interaction was between CuO and CeO2 rods, followed by CuO/CeO2 polyhedra, and the CuO/CeO2 cubes showed the least interaction. Importantly, Cu2+ ions could be incorporated into the pore and surface lattices by occupying the vacant sites in the nanostructure CeO2 rods. Partial copper oxide species were segregated on the surface of CeO2 cubes with larger particle sizes. As a result, the site geometry and coordination environment of Cu2+ ions were different on the (111), (110), and (100) surfaces of CeO2. This surface structure effect in turn led to a higher surface reducibility, activity and N2 selectivity of CuO/CeO2 nanorods for NO reduction at low temperatures (below 250 °C); the polyhedra and cubes were less active.
Heat Exchanger Network Integration Using Diverse Pinch Point and Mathematical Programming
Authors: Jiang N. , Bao S. , Gao Z. 
Published: April 2011

AbstractA design approach based on diverse pinch point and mathematical programming for optimal integration of heat exchanger networks (HENs) is described. The effect of the dissimilar film heat transfer coefficients on the area target is considered by different pinch and composite curves. The approach combines insightful pinch analysis and rigorous mathematical programming, which enable systematic and automatic designs. A software platform is developed for the design of HENs. An example illustrates the application of the proposed approach.
Combining Glycomimetic and Multivalent Strategies toward Designing Potent Bacterial Lectin Inhibitors
Authors: Chabre Yoann M. , Giguère Denis , Blanchard Bertrand , Rodrigue Jacques , Rocheleau Sylvain , Neault Mathieu , Rauthu Subhash , Papadopoulos Alex , Arnold Alexandre A. , Imberty Anne , Roy René 
Published: April 2011

AbstractAs part of ongoing activities toward the design of potent and selective ligands against galactoside‐binding proteins from animal, bacterial, and plant lectins, a systematic investigation involving the synthesis and binding evaluations of a series of original β‐C‐galactopyranoside mimetics is described. The multivalent presentation of partly optimized candidates on various dendritic scaffolds through CuI‐catalyzed azide–alkyne cycloaddition (CuAAc) has also been achieved. Biophysical investigations based on isothermal titration calorimetry (ITC) have indicated a dissociation constant in the low micromolar range for the best optimized monovalent conjugate (Kd=37 μM). The results thus confirmed that stable C‐galactosides could represent efficient synthetic glycomimetics of natural α‐linked oligosaccharidic inhibitors of PA‐IL lectin (Lec A) from the pathogenic Pseudomonas aeruginosa. Striking enhancements in the avidity of the glycoconjugates were also observed for tri‐, hexa‐, and nonavalent derivatives, among which the most potent exhibited dissociation constants below 500 nM, corresponding to a 400‐fold increase in affinity compared with the β‐D‐Gal‐O‐Me used as reference. To deepen our understanding of the binding mode of the best glycomimetics involved in the recognition process, molecular modeling studies, docking calculations, and NMR diffusion measurements have been performed. Although favorable complementary interactions induced by the addition of the hydrophobic aglycon might explain the affinity enhancement, experimental determination of the size and the topology of the multivalent conjugates further supported the formation of aggregative complexes as a major multivalent binding mode. This work represents a systematic and comprehensive study towards a thorough understanding of the protein–carbohydrate interactions involved in Pseudomonas aeruginosa infection, and as such should prove useful for the development of stable and optimized anti‐adhesive agents.
A Local Constitutive Model with Anisotropy for Various Homogeneous 2D Biaxial Deformation Modes
Authors: Luding Stefan , Perdahcıoğlu Emin Semih 
Published: April 2011

AbstractA local constitutive model for granular materials with anisotropy is proposed and applied to different biaxial box deformation modes. The simplified version of the model (in the coordinate system of the biaxial box) involves only scalar values for hydrostatic and shear stresses, for the isotropic and shear strains as well as the new parameter, the (scalar) anisotropy modulus. A non‐linear constitutive evolution equation, for both shear stress and anisotropy, during deviatoric (shear) deformation, is based on observations gained from Discrete Element Method (DEM) simulations. While parameters like the bulk modulus are set to constant, for the sake of simplicity, the model involves a yield stress and a maximal anisotropy as well as the corresponding deviatoric shear‐rate pre‐factors for incremental stress and incremental anisotropy modulus. In this study, the self‐consistency of the simple‐most model is discussed before it is applied to various bi‐axial deformation modes. Constant anisotropy is compared to evolving anisotropy, where the sign accounts for the direction (tension or compression corresponds to positive or negative strain, respectively). Generalization to arbitrary orientation and possible non‐coaxial strain, stress and fabric tensors is not yet attempted in this study.
Experimental investigation of double gas hydrate formation in the presence of modified starch as a kinetic inhibitor in a flow mini‐loop apparatus
Authors: Talaghat Mohammad Reza 
Published: April 2011

AbstractThe main objective of the present work is experimental investigation of double gas hydrate formation with or without presence of modified starch as kinetic inhibitors in a flow mini‐loop apparatus. To this object, a laboratory flow mini‐loop apparatus was set up to measure the induction time for hydrate formation and the rate uptake when a gaseous mixture (such as 75% C1–25% C3, 25% C1–75% C3, 75% C1–25% i‐C4 and 25% C1–75% i‐C4) is contacted with water containing or not containing dissolved inhibitor under suitable temperature and pressure conditions. In each experiment, water blend saturated with gas mixture is circulated up to a required pressure. Pressure is maintained at a constant value during experimental runs by means of required gas mixture make‐up. The effect of pressure on gas consumption during hydrate formation is investigated with or without presence of polyvinylpyrrolidone and modified starch as kinetic inhibitors at various concentrations. Our results were shown that the modified starch can be applied as inhibitors in prevention of double gas hydrate formation in mini‐loop apparatus. © 2011 Canadian Society for Chemical Engineering
Numerical investigation of FLUID COKING™ units, Part II: Modelling of feed vaporisation
Authors: Li Tingwen , Grace John , Bi Xiaotao , Reid Kevin , Wormsbecker Michael 
Published: April 2011

AbstractThe hydrodynamics of FLUID COKING™ units are investigated with computational fluid dynamics (CFD). The vaporisation of liquid feed is simulated by introducing limiting assumptions to simplify and bound the process: (a) liquid feed entirely vaporised at the entrance of the column; (b) liquid feed vaporised immediately upon contact with the coke particles; and (c) liquid coated uniformly on the particles, with vapour generated uniformly throughout the bed. Results predicted under these extreme scenarios are compared. Then, two cases with a relatively realistic description of liquid–solid interaction and feed vaporisation are simulated. The vaporisation rate is found to play an important role in affecting the flow hydrodynamics. Based on the local liquid‐to‐solid ratio and shear stress distribution, an agglomeration index is introduced to characterise the stability of agglomerates in the reactor. The vaporisation rate of liquid film on particles is shown to affect the distribution of the agglomeration index. The results indicate that a high vaporisation rate tends to decrease both agglomeration and stripper fouling. © 2011 Canadian Society for Chemical Engineering
Numerical investigation of FLUID COKING™ units, Part I: Hydrodynamics of a scaled cold flow model
Authors: Li Tingwen , Grace John , Bi Xiaotao , Reid Kevin , Wormsbecker Michael 
Published: April 2011

AbstractThe hydrodynamics of a FLUID COKING™ unit were investigated with computational fluid dynamics (CFD) by simulating a scaled cold flow model. Steady state flow hydrodynamics were then analysed by focusing on the local voidage distribution and solids velocity. The influence of simulation time on interpretation and analysis of results was evaluated first, and a short‐time simulation was found to be able to provide useful information. The predicted flow behaviour was compared both quantitatively and qualitatively with previous experimental findings. The influences of nozzle‐insertion, feed distribution, and solids circulation rate were investigated. The numerical simulations indicated that the nozzle insertion and solids circulation have little impact on the flow hydrodynamics for the range of conditions studied. © 2011 Canadian Society for Chemical Engineering
Synthesis and Antitumor Activity of 3‐(2‐Phenyl‐1,3‐thiazol‐4‐yl)‐1H‐indoles and 3‐(2‐Phenyl‐1,3‐thiazol‐4‐yl)‐1H‐7‐azaindoles
Authors: Diana Patrizia , Carbone Anna , Barraja Paola , Montalbano Alessandra , Parrino Barbara , Lopergolo Alessia , Pennati Marzia , Zaffaroni Nadia , Cirrincione Girolamo 
Published: April 2011

AbstractGiven the potent antimicrobial, antiviral, and antitumor activities of many natural products, there is an increasing interest in the synthesis of new molecules based on natural compound scaffolds. Based on a 2,4‐bis(3′‐indolyl)imidazole skeleton, two new series of phenylthiazolylindoles and phenylthiazolyl‐7‐azaindoles were obtained by Hantzsch reaction between substituted phenylthioamides and the α‐bromoacetyl derivatives. Some azaindole derivatives, tested at the National Cancer Institute against a panel of ∼60 tumor cell lines derived from nine human cancer cell types, showed inhibitory effects against all cell lines investigated at micromolar to nanomolar concentrations. Two of them exhibited a high affinity for CDK1, with IC50 values of 0.41 and 0.85 μM. These promising results will set the foundation for future investigations into the development of anticancer therapies.
Racial variation in willingness to trade financial resources for life‐prolonging cancer treatment
Authors: Martin Michelle Y. , Pisu Maria , Oster Robert A. , Urmie Julie M. , Schrag Deborah , Huskamp Haiden A. , Lee Jeannette , Kiefe Catarina I. , Fouad Mona N. 
Published: April 2011

AbstractBACKGROUND:Minority patients receive more aggressive care at the end of life, but it is unclear whether this trend is consistent with their preferences. We compared the willingness to use personal financial resources to extend life among white, black, Hispanic, and Asian cancer patients.METHODS:Patients with newly diagnosed lung or colorectal cancer participating in the Cancer Care Outcomes Research and Surveillance observational study were interviewed about myriad aspects of their care, including their willingness to expend personal financial resources to prolong life. We evaluated the association of race/ethnicity with preference for life‐extending treatment controlling for clinical, sociodemographic, and psychosocial factors using logistic regression.RESULTS:Among patients (N = 4214), 80% of blacks reported a willingness to spend all resources to extend life, versus 54% of whites, 69% of Hispanics, and 72% of Asians (P<.001). In multivariate analyses, blacks were more likely to opt for expending all financial resources to extend life than whites (odds ratio, 2.41; 95% confidence interval, 1.84‐3.17; P < .001).CONCLUSIONS:Black cancer patients are more willing to exhaust personal financial resources to extend life. Delivering quality cancer care requires an understanding of how these preferences impact cancer care and outcomes. Cancer 2011;. © 2011 American Cancer Society.
Outcomes and metrics
Authors: Greenberg Mark , Klassen Anne , Gafni Amiram , McBride Mary L , Albritton Karen 
Published: April 2011

AbstractAgainst a background of poorly coordinated provision of holistic care to the adolescent and young adult (AYA) cancer population, the Canadian National Task Force on Adolescent and Young Adult Oncology, which is supported by the Canadian Partnership Against Cancer and the C17 network, convened a workshop to formulate the components of a systematic approach to care for this age group. Because such a program will deflect scarce resources, it must be validated and justified by reproducible metrics. A subgroup of experts was convened, comprising attendees at the AYA workshop, including AYA cancer survivors. A substantial number of key, feasible, and consistent metrics were identified and are systematized, justified, and presented in this article. Prioritization from within this range will be necessary. Cancer 2011;117(10 suppl):2342–50. © 2011 American Cancer Society.
Opportunities and challenges of establishing a nationwide strategy for adolescents and young adults in Canada with cancer
Authors: Robison Leslie L. 
Published: April 2011

AbstractCurrently, there is priority to address the complex needs of the adolescent and young adult (AYA) cancer population. At a workshop in Toronto, the Canadian healthcare community brought together a broad range of stakeholders to discuss the opportunities and challenges of developing a nationwide strategy for AYA cancer patients. Summarized here is an overview of the workshop objectives and considerations coming from the conference participants relative to opportunities, challenges, and future directions. It is concluded that the Canadian healthcare and advocacy communities are well‐positioned to have a major impact and assume a leadership role in AYA cancer care. Cancer 2011;117(10 suppl):2351–4. © 2011 American Cancer Society..
Critical issues in transition and survivorship for adolescents and young adults with cancers
Authors: Nathan Paul C. , Hayes‐Lattin Brandon , Sisler Jeffrey J. , Hudson Melissa M. 
Published: April 2011

AbstractThe majority of children, adolescents, and young adults diagnosed with cancer will become long‐term survivors with many potential years of life ahead of them. Their journey from health through diagnosis and treatment to survivorship involves multiple transitions. Transitional services that should be available throughout this journey include health‐related education, health surveillance and screening, management of cancer‐related complications, and psychosocial support relevant to their developmental needs. Survivors require lifelong care that focuses not only on the medical risks arising from their cancer therapy, but also the psychosocial, educational, and vocational implications of surviving cancer. Because many community health care providers lack familiarity with the health risks associated with childhood or adolescent/young adult cancer, survivors must have sufficient health knowledge to advocate for risk‐based cancer‐related follow‐up; the provision of a treatment summary and care plan at the conclusion of their cancer therapy is an important tool for facilitating this process. The availability of resources for survivors varies by geography, health care system, and survivor characteristics. Adolescents and young adults who receive their care outside of a pediatric cancer center have particularly limited access. The limitations in cancer center resources (along with survivor preference) strongly suggest that the long‐term care of survivors will need to be shared between the cancer centers and primary care providers in survivors' communities. Cancer 2011;117(10 suppl):2335–41. © 2011 American Cancer Society.