bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the Consumption of Medicinal Products Associated with a High Risk of Drug-Induced Liver Injury in Patients with COVID-19
Authors: Petrov V. I. , Ryazanova A. Yu. , Tokareva N. S. 
Published: May 2024

INTRODUCTION. The risk of liver damage correlates with the severity of COVID-19. However, a growing number of studies have shown an association between liver function impairment and combinations of medicinal products used to treat COVID-19.AIM. The study aimed to analyse the annual consumption of medicinal products associated with a high risk of drug-induced liver injury (DILI) used as part of combination therapy in COVID-19 patients and to review a number of medication administration records in order to develop measures to prevent DILI.MATERIALS AND METHODS. The study used the ATC/DDD methodology to study consumption data for 2020, 2021, and 2022 and analysed a sample of 1250 inpatient medical records and medication administration records of COVID-19 patients treated in a Volgograd region hospital converted into a COVID-19 care centre. For genetically engineered biologicals and cyclophosphamide, which were lacking DDDs, the authors calculated the volume of consumption using the average dose per treatment course. The authors identified medicines capable of causing clinically apparent liver damage (according to the LiverTox database and Russian clinical practice guidelines) and/or elevated liver enzymes in ≥1% of patients (according to safety reports).RESULTS. The study found that 28% of the medicinal products used in combination for inpatient treatment of COVID-19 were associated with a high risk of DILI. In 2020, 2021, and 2022, the total consumption of medicinal products associated with a high risk of DILI was 342.3, 425.3, and 402.3 DDDs per 100 bed days, and the total consumption of genetically engineered biologicals (administered as a single dose) and cyclophosphamide was 3.5, 16.9, and 29.7 average course doses per 100 patients, respectively. According to the selective analysis of medical records, 19.8% (247/1250) reported concomitant use of 5 or more medicinal products associated with a high risk of DILI, which increased the risk of adverse drug interactions leading to DILI. In 2022, the most prescribed medicinal products with a high risk of DILI were omeprazole (188.7 DDDs per 100 bed days), non-steroidal anti-inflammatory drugs and paracetamol (54.4 DDDs per 100 bed days), atorvastatin (46.2 DDDs per 100 bed days), levofloxacin (26.4 DDDs per 100 bed days), ceftriaxone (20.5 DDDs per 100 bed days), favipiravir (17.3 DDDs per 100 bed days), and genetically engineered biologicals (24.0 DDDs per 100 bed days).CONCLUSIONS. To reduce the risk of DILI in COVID-19 patients admitted to infectious disease units, including the risk of DILI due to drug interactions, it is necessary to limit the use of hepatotoxic antibacterial agents, proton-pump inhibitors, and non-steroidal anti-inflammatory drugs, or consider alternative medicinal products with a lower risk of hepatotoxicity.
Methodological aspects of using NIR spectroscopy to assess biochemical indicators in barley grain
Authors: Popov V. S. , Shelenga T. V. , Kovaleva O. N. , Khoreva V. I. 
Published: May 2024

Background. The possibility of applying near-infrared reflectance (NIR) spectroscopy for rapid assessment of various biochemical parameters in barley varieties and forms is discussed. The data obtained by the Biochemistry and Molecular Biology Department of VIR served to construct calibration models for the content of protein, starch, oil, beta-glucans, and total phenolic compounds (PhC) in grain, facilitating further screening of various barley samples.Materials and methods. The chemical composition of grain was studied in naked and covered spring barley (Hordeum vulgare L.) accessions grown in 2022 in the northwest of Russia. Calibration models were developed to measure the content of protein, oil, starch, beta-glucans, and PhC (80 accessions) in barley grain with the Matrix-I IR analyzer (Bruker Optics, Germany). The models were constructed on the basis of the data obtained by conventional techniques of chemical analysis. The protein/ nitrogen content was assessed using the Kjeldahl method, oil according to the method of defatted dry residue modified by S. V. Ruszkovsky, starch by the polarimetric method according to Evers, beta-glucans by gravimetric analysis, and the total PhC content by the Folin–Ciocâlteu method modified by Singleton and Rossi.Results. Statistical significance of the constructed calibration tests was compared with the results of measuring protein, starch, oil, beta-glucan and PhC levels by chemical methods. It was shown that the data of calibration techniques for protein and starch were significant, while the remaining models required improvement.Conclusion. The proposed method helps to preserve valuable source material, increases labor efficiency, and does not require chemical reagents. Scanning each sample makes it possible to obtain data for several indicators at once, with a specified replication and standard deviation.
Features of the water regime and photosynthesis in hybrid forms of cherry plum under the dry wind season conditions
Authors: Grigoriev A. V. , Pilkevich R. A. , Lukicheva L. A. , Gubanova T. B. , Gorina V. M. 
Published: May 2024

Background. The results of a study on the drought resistance of cherry plum hybrid forms are presented. Water retention capacity of leaves and chlorophyll fluorescence were measured under the simulated conditions close to the dry wind season.Materials and methods. The water regime parameters were studied for five cherry plum genotypes in 2021 and 2022. Leaves of four hybrid forms developed at the Nikita Botanical Gardens and the reference cherry plum hybrid cultivar ‘Rumyanaya Zorka’ (Prunus rossica Erem.) were taken into the experiments. Using the guidelines by G. N. Eremeev and A. I. Lishchuk, a series of experiments on controlled leaf wilt at the air temperature of +27°C and relative humidity of 30% were conducted on cherry plum to assess the functional state of the photosynthetic apparatus during the development of water stress under dry wind conditions. The experiments were carried out in a Binder climate chamber. Chlorophyll fluorescence was measured using a portable Floratest fluorometer. The measurements were based on the parameters of the chlorophyll fluorescence induction curve (CFI) obtained on native leaves. The leaves of cv. ‘Rumyanaya Zorka’ in the state of complete watering served as the reference.Results and discussion. Dependence was identified between chlorophyll fluorescence and moisture content in the leaves of the studied samples. The hybrids were found to respond to drought in different ways. A relatively increased ability to retain moisture during dehydration was observed in form 12/26 whose leaves gave off moisture more slowly and restored their turgor better. It is promising for cultivation in areas with insufficient water supply. Form 99/36 had the lowest potential drought resistance. Forms 99/14 and 9/28 occupied an intermediate position.
Ontogenetic features of <I>Saposhnikovia divaricate</I> (Turcz.) Schischk. introduced into the environments of the Cis-Baikal Region
Authors: Khudonogova E. G. , Polovinkina S. V. 
Published: May 2024

Background. Saposhnikovia (Saposhnikovia Schischk.) is a monotypic genus occurring in the south of Eastern Siberia, the Far East, Mongolia, Manchuria, and Korea. Saposhnikovia divaricata (Turcz.) Schischk. grows in Baikal Siberia and Transbaikalia, but does not occur in the Cis-Baikal Region. Roots, grass and fruits of S. divaricata are used in Oriental medicine as an anti-inflammatory and antipyretic agent. The species is promising for introduction into domestic medical practice. Currently, its area of distribution is rapidly shrinking due to the uncontrolled collection of roots for medicinal purposes. Plant introduction studies can solve the problem of sustainable utilization and conservation of the species.Materials and methods. Ontogenetic features of S. divaricata were studied in the experimental field of Irkutsk State Agrarian University for three years. The age composition of the species was analyzed according to T. A. Rabotnov’s methodology, taking into account the publications by L. B. Zaugolnova with coauthors and E. L. Nukhimovsky.Results and conclusions. S. divaricata is an aboveground two-seeded semi-deciduous plant; its seed germination rate is 87– 90% in the laboratory, and 85–88% in the field. Its plants in the first year of their life pass through the stages of the pregenerative period and proceed into the winter season in a virginal state. About 6% of the plants enter the generative state in the second year of life, and all the rest do it in the third year. The highest root weight was recorded in virginal plants in their second year of life (12.48 g). S. divaricata is a species of mediocre prospects for introduction into the environments of the Cis-Baikal Region.
Rapid assessment of the main economic value indicators in lupine flour samples using infrared spectroscopy
Authors: Popov V. S. , Salikova A. V. , Perchuk I. N. , Konkova N. G. , Egorova G. P. , Vishnyakova M. A. , Shelenga T. V. 
Published: May 2024

Background. A calibration model has been developed for rapid assessment of economic value indicators (protein, oil, and quinolizidine alkaloid contents) in the seeds of narrowleaf lupine accessions from VIR using near-infrared spectroscopy, with the help of which it is possible to decide on the further use of the accessions.Materials and methods. Biochemical quality indicators (protein, oil, and quinolizidine alkaloid content) were studied in the seeds of narrowleaf lupine (Lupinus angustifolius L.) grown in 2019 in the northwest of Russia. Calibration models for measuring protein, oil and alkaloids in lupine seeds (62 accessions) were developed using a MATRIX-I IR analyzer (Bruker Optics, Germany). To construct calibration models, we used the values obtained by chemical analysis methods accepted at VIR. The oil content in lupine seeds was assessed by the defatted dry residue technique in Soxhlet extractors, protein by the Kjeldahl method, and quinolizidine alkaloids by gas chromatography coupled with mass spectrometry. All indicators were recalculated on the dry-weight basis.Results and conclusion. Statistical significance of the developed models was verified according to the results of measuring the content of protein, oil and alkaloids in the seeds of the test batch. The protein and oil content data obtained using a calibration curve did not differ significantly from the results of chemical studies, in contrast to alkaloid indicators. Consequently, the developed calibration model for the MATRIX-I IR analyzer can be used for rapid assessment of protein and oil content in narrowleaf lupine flour samples, thus accelerating the process of obtaining data on the main economic value indicators. The analysis does not require reagents and is safe.
Identification of Nursing Students' Anxiety and Readiness Facing Ners Competency Tests; Qualitative Study
Authors: Suzanna  , Inne Yellisni  , Gunawan Irianto  , Arif Setyo Upoyo  
Published: May 2024

Background: Having a registration certificate (STR) a nurse must take a competency test as a condition for ownership of the STR. For nursing students, competency tests are a big challenge and complex, so special preparation and attention are needed for students and universities. The implementation of the competency test can create feelings of concern, fear, tension, and anxiety for fear of not passing the competency test. The problem about low graduation rate for ners competency test is influenced by several factors. One of internal factor consist of anxiety and fear facing ners competency test.
Purpose: This study identified the perception and experience anxienty dan readiness of few nursing students facing competency test.
Method: The study design is qualitative and study was conducted using semi-structured interview. Recruitment of partisipants for the interview was based on purposive sampling methods. Interview were conducted with a maximum 14 participants with saturation data. Analiysis in this study with content analysis.
Results: This study explored the perception and experience anxienty dan readiness of few nursing students facing competency test. The current study identified four themes : deep feeling of fear, extreme anxiety, unpreparedness within, surrender and pray.
Conclusion: The feelings of anxiety, fear and worry felt by students whether they are taking an exam for the first time or those who are repeating it. In fact, this feeling has quite an impact on the psychological condition, which is also compounded by the student's unpreparedness facing ners competency test.
Tuna, Moringa And Tempe As A High Energy, High Protein Gimbap Bite For Pregnant Women With Chronic Energy Deficiency
Authors: Wulandari Catur Ima , Puspita Theresia , Hadisuyitno Juin 
Published: May 2024

The problem with nutrition that occurs in mothers pregnant is Chronic Energy Deficiency (KEK). Intake of energy and protein in the mother pregnant classified low below 70% figure adequacy amounting to 52.6% and 52.2%. Treatment to overcome Chronic Energy Deficiency in Pregnant Women by giving additions food made from local tuna, moringa, and tempeh. Obtain formulation tuna , moringa and tempeh as gimbap bite for pregnant women with chronic energy deficiency. This study used type study experiment with design study design random complete (RAL) with treatment formulation of tuna, moringa and tempeh . Experiments carried out consist of three levels of treatment (50:30:20), (45:25:30), and (40:20:40). Amino Acid score was more than 100 and the NPU and VC values were ?70. Data on organoleptic properties were collected by organoleptic test using hedonic method and statistically analyzed using Friedman at the 95% confidence level (p=0,05). Gimbap tuna, moringa, and tempeh in 100 grams own content energy 190.4-192,6 kcal , protein 6.9-7.1 grams, fat 6.1-6.4 grams and carbohydrates 27.2-27,4 grams. Gimbap tuna, moringa, and tempeh were not difference significant color, aroma, taste, and texture (p>0,05). Gimbap with the proportion of tuna 45: Moringa 25: tempeh 35 contains 370,7 kcal , 13.4 grams of protein, 12.3 grams of fat, and 51.9 grams of carbohydrates meets 15,2% of the needs for energy and 21,9% of maternal protein requirements for pregnant women .
ТЕОРЕТИЧНІ ДОСЛІДЖЕННЯ ФОРМ БІЗНЕС-ПАРТНЕРСТВА СУБ’ЄКТІВ ГОСПОДАРЮВАННЯ
Authors: КАРВАЦКА Наталія , ЗАБЛОЦЬКИЙ Олександр 
Published: May 2024

У статті було досліджено форми бізнес-партнерства суб’єктів господарювання, а саме: організаційно-правові форми господарювання корпоративних підприємств, підприємств колективної власності, об’єднань підприємств; договірного регулювання господарських взаємовідносин; проєктного бізнес-партнерства. Зокрема аналіз правової сфери регулювання діяльності корпоративних підприємств дав авторам можливість зробити висновок, що такі суб’єкти господарювання визначаються стійкими зв’язками, є єдиними майновими комплексами. У статті зазначено, що застосування терміну «бізнес-партнерство» до корпоративного підприємства є невірним, оскільки в основі бізнес-партнерства має бути взаємодія (співпраця) двох або більше незалежних сторін для досягнення спільної мети.
Наступним було досліджено особливості функціонування об’єднань підприємств. У статті визначено, що об’єднання підприємств передбачає створення вищих органів управління з передачею ним у більшій чи меншій мірі повноважень (залежно від організаційно-правової форми) централізованого регулювання діяльності учасників. У цілому вони є стійкими інтеграціями, що спрямовані на досягнення спільних стратегічних цілей і передбачають часткову втрату автономності. Авторами зазначено, що у випадку змін інтересів компаній учасників така форма співпраці стає обтяжливою.
Далі у статті було досліджено взаємовідносини суб’єктів господарювання на договірній основі. Такі форми партнерства визначено як доволі гнучкі. Однак зважаючи на те, що основною метою контрактних міжфірмових відносин є прибуток, було відмічено, що будь-яка зацікавленість сторін крім цього аспекту вторинна. Автори звертають увагу на комерційну основу співпраці таких взаємовідносин. Договірні взаємовідносини суб’єктів господарювання зазвичай спрямовані на чітке виконання завдань контрагентів без акценту на загальні цілі. Відповідно відсутність спільного інтересу може призвести до розбіжностей у розумінні завдань та стратегій. Окрім цього у разі співпраці на договірній основі важко гарантувати взаємний обмін ідеями та знаннями.
Найбільш гнучкими і адаптивними, на думку авторів, є тимчасові форми співробітництва, що створюють для реалізації спільного підприємницького проєкту. Авторами визначено проєктне бізнес-партнерство як «форму співпраці між бізнес-структурами чи організаціями для досягнення спільної мети або реалізації конкретного завдання шляхом об'єднання ресурсів, зусиль, досвіду й пропорційного розподілу ризиків і винагороди з використанням методології проєктного управління», наведено головні ефекти використання такої форми співпраці.
Strategi Pemasaran Varietas Cabai OP Seloka IPB dan Anies IPB
Authors: Ginantaka Aditia 
Published: May 2024

Pengembangan varietas baru cabai merupakan salah satu langkah strategis untuk mendukung pasokan kebutuhan cabai. Kebutuhan cabai tidak hanya ditujukan pada skala industri, tetapi juga untuk kebutuhan skala rumah tangga. Kajian ini bertujuan untuk menganalisis strategi komersialisasi yang tepat untuk memasarkan benih cabai OP Seloka IPB dan Anies IPB yang merupakan invensi dari peneliti IPB. Metode kajian menggunakan pendekatan deskriptif kualitatif dengan menggunakan analisis bauran pemasaran, analisis STP (segmenting, targetting dan positioning) serta analisis BMC (business model canvas). Hasil analisis menunjukan kajian ini dapat menjadi pertimbangan perusahaan dalam menyelaraskan strategi pemasaran benih cabai. Hasil perancangan model bisnis telah berhasil menyusun pemetaan terkait operasionalisasi bisnis benih cabai.
The main hypotheses of the colour and light colour gradient of architectural activity
Authors: Kondratska Olha 
Published: May 2024

The author's colour and light studies, in particular, the construction of a mathematical model of colour and light architectural activity, are based on a number of hypotheses, the first and foremost of which is the fundamental hypothesis of the existence of a natural attraction to colour and light architectural activity. The presented hypotheses - about the manifestation of the colour and light-colour gradient of architectural activity - are based on our own research [1-3], as well as on the research of other authors [9-16], and on the research of Doctor of Architecture Prof. V.V. Tovbych [4-8]. In particular, in general, the hypotheses regarding the manifestation of the colour and light colour gradient of architectural activity are conditionally divided into three generalised groups: the fundamental and philosophical gradient (Hypotheses 1-2) regarding the existence of a natural attraction to colour and light architectural activity; the theoretical and applied gradient (Hypotheses 3-31) regarding the definition of the main dynamic indicators of the development of a dynamic colour and light architectural and construction system; and the group on the fundamentally generalised definition of the functional connection between the process of manifestation of the impulse in colour and light architectural activity (against the background of the manifestation of the attraction to architectural activity) and the process of manifestation of the passional impulse in the ethnogenesis of L. M. Gumilev (Hypotheses 32-33). This "colour and light-colour" gradient of distribution is fully consistent with the generalised gradient of distribution of relevant hypotheses about the manifestation of architectural and urban planning activities, which was first introduced into architectural science by Doctor of Architecture, Professor V.V. Tovbych [5]. Given the short scope of the publication, only the first set of the most important hypotheses regarding the manifestation of the colour and light-colour gradient of architectural activity is presented below.
APPLICATION OF GENERALIZED EXTREME VALUE DISTRIBUTION TO ANNUAL MAXIMUM RAINFALL
Authors: Ilesanmi Anthony O. , Halid Omobolaji Y. , Adejuwon Samuel O. , Odukoya E. Ayooluwa , Olayemi M. Sunday 
Published: May 2024

Generalized Extreme Value Distributions was used to model annual maximum rainfall data in Akure, Ondo State, Nigeria from 1981-2019. The parameters of the distribution are estimated using the maximum likelihood estimation method. The model fit indicated that the shape parameter is negative this suggests that Fréchet distribution is the appropriate model for describing annual maximum rainfall in Ondo-state Nigeria. The estimated return levels for different return periods revealed an increase in the value over the years.
LENGTH-WEIGHT RELATIONSHIP OF CLARIAS GARIEPINUS FED PSIDIUM GUAJAVA AND MANGIFERA INDICA LEAF EXTRACT
Authors: Ekpemikoghene Ikenga Esther , Arimiche Nwabueze Agatha , Kesena Ekelemu Jerimoth 
Published: May 2024

The length weight relationship (LWR) of Clarias gariepinus fed Psidium guajava and Mangifera indica leaf extract was evaluated for six (6) months. A total of 420, eight (8) weeks old fingerlings of Clarias gariepinus was used for this study. Experimental fish were fed 40 % crude protein diet with inclusion of both leaf extracts at 0 %, 4 %, 6 %, and 8 %. Experimental fish were stocked in twenty-one 4ft by 4ft tarpaulin tanks half filled with borehole water, acclimation was done for 7 days during which they were fed commercial diet. Aqueous extract was done for both leaves and stored in plastic cans for further use. Weight and length of fish was measured biweekly and data was used to assess the length-weight relationship. The result of this study showed that the best weight was recorded in treatment 2 fed 4 % Psidium guajava extract and the least in treatment 5 fed 4 % Mangifera indica extract. The result on LWR revealed the regression coefficient ‘b’ to be from 17.68-20.40 which indicates a positive allometric growth, since ‘b’ value is more than 3. This further means that the fish samples in this study became heavier, stouter, deeper bodied or bigger as it increases in length i.e all parts of the fish increase in size proportionately with the length.