bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automated RNA tertiary structure prediction from secondary structure and low‐resolution restraints
Authors: Seetin Matthew G. , Mathews David H. 
Published: April 2011

AbstractA novel protocol for all‐atom RNA tertiary structure prediction is presented that uses restrained molecular mechanics and simulated annealing. The restraints are from secondary structure, covariation analysis, coaxial stacking predictions for helices in junctions, and, when available, cross‐linking data. Results are demonstrated on the Alu domain of the mammalian signal recognition particle RNA, the Saccharomyces cerevisiae phenylalanine tRNA, the hammerhead ribozyme, the hepatitis C virus internal ribosomal entry site, and the P4–P6 domain of the Tetrahymena thermophila group I intron. The predicted structure is selected from a pool of decoy structures with a score that maximizes radius of gyration and base–base contacts, which was empirically found to select higher quality decoys. This simple ab initio approach is sufficient to make good predictions of the structure of RNAs compared to current crystal structures using both root mean square deviation and the accuracy of base–base contacts. © 2011 Wiley Periodicals, Inc. J Comput Chem, 2011
Reexperiencing symptoms and the interpersonal‐psychological theory of suicidal behavior among deployed service members evaluated for traumatic brain injury
Authors: Bryan Craig , Anestis Michael 
Published: April 2011

AbstractRecent evidence suggests that military suicide rates now exceed those of the general public. Numerous recent efforts to address this growing concern have focused on the interpersonal psychological theory of suicidal behavior (IPTS). In the current study, we explored the relationships among reexperiencing symptoms of posttraumatic stress disorder and the three components of the IPTS in a sample of deployed military personnel examined for traumatic brain injury. Results indicated that reexperiencing symptoms were directly related to the acquired capability for suicide, but their relationships to perceived burdensomeness and thwarted belongingness were statistically explained by general mental health distress. Results indicate that mental rehearsal of painful and provocative experiences may have an impact on suicide risk. © 2011 Wiley Periodicals, Inc. J Clin Psychol 67:1–10, 2011.
Synthesis, anti‐inflammatory, and anticancer activity evaluation of some heterocyclic amidine and bis‐amidine derivatives
Authors: Sondhi Sham M. , Rani Reshma , Roy Partha , Agrawal S. K. , Saxena A. K. 
Published: April 2011

AbstractHeterocyclic amidine derivatives of benzothiazole (6a, 6b, 6c), benzimidazole (6d, 6e, 6f), benzoxazole (6g, 6h, 6i), and bis‐amidine derivatives of pyrimidine, (7a, 7b) & triazole (7c, 7d, 7e) ring system have been synthesized by nucleophilic addition reaction. All these compounds were screened for anti‐inflammatory and anticancer activities. At a dose of 50 mg/kg p.o., compounds 6c (39%), 6e (39%), and 6f (39%) exhibited anti‐inflammatory activity comparable to standard drug ibuprofen, which showed 39% activity and compounds 6b, 6e, 7a, and 7c exhibited moderate anticancer activity against cervix (HELA); neuroblastoma (IMR‐32); breast (MCF‐7), leukemia (THP‐1); and cervix (HELA) human cancer cell lines, respectively. J. Heterocyclic Chem., (2011).
Design, synthesis, and cytotoxic activity evaluation of new linear pyranoxanthone aminoderivatives
Authors: Kolokythas George , Daniilides Konstantinos , Pouli Nicole , Marakos Panagiotis , Pratsinis Harris , Kletsas Dimitris 
Published: April 2011

AbstractWith the aim of enlightening some structure‐activity correlation within the pyranoxanthenone series, we have designed and synthesized a number of new 5‐aminosubstituted pyrano[3,2‐b]xanthen‐6‐ones bearing various 12‐substituents. In vitro cytotoxic potencies of the new derivatives toward the murine leukemia L1210 cell line, human colorectal adenocarcinoma (HT‐29), and human uterine sarcoma (MES‐SA and its 100‐fold resistant to doxorubicin variant MES‐SA/Dx5) cell lines, are described and compared with that of reference drugs. Among the studied compounds, those possessing a second aminosubstituted side‐chain exhibit interesting cytotoxic activity against the solid tumor cell lines, and they retain activity against the multidrug resistant MES‐SA/Dx5 subline. Their selective effect on a phase of the cell cycle was evaluated using HT‐29 cells providing evidence that the compounds induce a G0/G1 arrest. J. Heterocyclic Chem., (2011).
Hepatitis B virus (HBV) X gene diversity and evidence of recombination in HBV/HIV co‐infected persons
Authors: Martin Christina M. , Welge Jeffrey A. , Blackard Jason T. 
Published: April 2011

AbstractThe high frequency of mutation during hepatitis B virus (HBV) infection has resulted in 8 genotypes (A–H) with varying effects on disease severity and treatment efficacy. However, analysis of intrapatient HBV diversity is limited, especially during HIV co‐infection. Therefore, a preliminary study was performed to analyze HBV X gene diversity in 17 HBV/HIV co‐infected individuals. Phylogenetic analysis revealed HBV genotype A in 13 individuals (76.5%) or genotype E in 1 individual (5.9%). Additionally, 3 individuals were dually infected with HBV genotypes A and G (17.6%). Overall, higher genetic distance and entropy were observed in the X region and overlapping polymerase (Pol(X)) regions when compared to the PreS, S, and overlapping polymerase (Pol(PS) and Pol(S)) regions analyzed in the same patients as part of a previous study. In addition, multiple viral variants from 2 individuals with dual HBV infection did not group with either genotype A or G by phylogenetic analysis, indicating possible recombination. SimPlot bootscan analysis confirmed recombination breakpoints within the X gene in both individuals. Recombination between HBV genotypes may represent an important evolutionary strategy that enhances overall pathogenic potential and/or alters the downstream effects of the HBV X protein. J. Med. Virol. 83:1142–1150, 2011. © 2011 Wiley‐Liss, Inc.
Vitamin E blended Uhmwpe may have the potential to reduce bacterial adhesive ability
Authors: Banche Giuliana , Bracco Pierangiola , Bistolfi Alessandro , Allizond Valeria , Boffano Michele , Costa Luigi , Cimino Andrea , Cuffini Anna Maria , del Prever Elena Maria Brach 
Published: April 2011

AbstractBiomaterial‐associated infection (BAI), a clinical problem resulting in septic failure of joint replacement implants, is initiated by bacterial adhesion, often byStaphylococcus epidermidis. Ultra high molecular weight polyethylene (UHMWPE) is a material of choice for joint replacement; reducing the adhesion ofS. epidermidisto the polymer could be a means to decrease infection. We examined the adhesion of two ATCC and one clinical strain ofS. epidermidisto standard polyethylene (PE), vitamin E blended UHMWPE (VE‐PE), and oxidized UHMWPE (OX‐PE) after different incubation times: a significant (p < 0.01) decrease in the adhered staphylococci on VE‐PE and a significantly higher incidence of the dislodged biofilm bacteria on OX‐PE was observed compared with that registered on PE. With attenuated total reflectance (ATR)–FTIR spectroscopy before and after suspension in bacterial medium for 48 h, new absorptions were observed mainly in OX‐PE, indicating adsorption of protein‐like substances on the polymer surface. We hypothesized that the different hydrophilicity of the surfaces with different chemical characteristics influenced protein adsorption and bacterial adhesion. These results may have clinical implications concerning the prevention of septic loosening: the VE‐PE could have the potential to reduceS. epidermidisadhesive ability if the preliminary data observed in these selected strains is further confirmed, as diversity among clinical strains is well known. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 29:1662–1667, 2011
Mass spectrometry of G‐quadruplex DNA: Formation, recognition, property, conversion, and conformation
Authors: Yuan Gu , Zhang Qiang , Zhou Jiang , Li Huihui 
Published: April 2011

AbstractG‐quadruplexes are special secondary structures formed from G‐rich sequences of DNA, and have proven to play important roles in a number of biological systems, including the regulation of gene transcription and translation. The highly distinctive nature of G‐quadruplex structures and their functions suggest that G‐quadruplexes can act as novel targets for drug development. As a highly sensitive analytical tool, mass spectrometry has been widely used for the analysis of G‐quadruplex structures. Electrospray‐ionization mass spectrometry, in particular, has found captivating applications to probe interactions between small molecules and G‐quadruplex DNA. In this review, we will discuss: (1) mass spectrometry probing of the formation, binding affinity, and stoichiometry between G‐quadruplexes and small molecules; (2) stabilization and collision‐dissociation behavior of G‐quadruplex DNA; (3) the exploration of the equilibrium transfer between a G‐quadruplex and duplex DNA; and (4) the ESI‐MS analysis of the conversion of intramolecular and intermolecular G‐quadruplexes. Finally, we will also introduce the application of new techniques in the analysis of G‐quadruplex conformation, such as ion‐mobility and infrared multiphoton‐dissociation mass spectrometry. We believe that, with the new technical developments, mass spectrometry will play an unparalleled role in the analysis of the G‐quadruplex structures. © 2010 Wiley Periodicals, Inc., Mass Spec Rev 30:1121–1142, 2011
Intracellular glutathione content influences the sensitivity of lung cancer cell lines to methylseleninic acid
Authors: Liu Chengfei , Liu Hongyu , Li Ying , Wu Zhihao , Zhu Yu , Wang Ting , Gao Allen C. , Chen Jun , Zhou Qinghua 
Published: April 2011

AbstractThe synthetic selenium compound methylseleninic acid (MSA) is a direct precursor of active methylselenol and appears to be the best candidate for studies on the mechanisms of selenium cancer prevention and therapy in vitro. Reduced glutathione (GSH) is critical to MSA metabolism, in addition to being a protective antioxidant which scavenges reactive oxygen species (ROS) and maintains the stability of intracellular redox status. In this study, we demonstrated that MSA has an anticancer effect in the human lung cancer cell lines L9981 and 95D using growth inhibition detection, cell‐cycle analysis, and apoptosis detection. We examined the role of intracellular GSH content and detected the ROS induced by MSA by fluorescence microscopy, and we used flow cytometry to quantify the ROS induced by pretreatment and co‐treatment with N‐acetylcysteine (NAC) and MSA. We also confirmed oxidative stress in MSA‐induced apoptosis. MSA inhibited lung cancer cell lines L9981 and 95‐D growth significantly, induced cell‐cycle arrest in the G1 phase and induced apoptosis. Compared to the control group, MSA significantly decreased intracellular GSH content in L9981 cells at higher concentrations of MSA (5 and 7.5 µM), while the intracellular GSH level was also dramatically decreased in L9981 cells treated with 5 µM MSA at different time points of 12‐ and 24‐h (decreased to about 50% and 20% of the control, respectively). Pretreatment with either NAC (GSH synthesis precursor) or buthionine sulfoximine (BSO, GSH synthesis inhibitor) in L9981 cells significantly inhibited the anti‐proliferative effect of MSA. MSA induced the generation of ROS, which was significantly reduced by NAC pretreatment. Furthermore, we also confirmed these results in another lung cancer cell line 95‐D. These results suggest that generation of ROS may be essential for the induction of oxidative stress and apoptosis by MSA in L9981 and 95‐D lung cancer cells. The balance between oxidative stress induced by MSA and the antioxidant effect exerted by intracellular GSH content may determine the ultimate outcome after MSA treatment. Mol. Carcinog. © 2011 Wiley Periodicals, Inc.
A high duty factor 35‐GHz pulse compression weather radar and rainfall observation
Authors: Lee Hoon , Kim Yong‐Hoon 
Published: April 2011

AbstractA new millimeter wavelength vertical weather radar system has been developed. It uses pulse compression technique and has the characteristics of more than half of duty factor with 5 W solid‐state power amplifier. Nonlinear FM waveforms based on Blackmanharris function at transmitter are generated for range sidelobe suppression. We successfully obtained equivalent radar reflectivity and Doppler mean velocity and these were compared with MRR at moderate rain events for the system verification. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26026
New dual‐band bandpass filter design based on slotted ground structures
Authors: Wang Xiao‐Hua , Xue Quan , Man Kim Fung 
Published: April 2011

AbstractTwo dual‐band bandpass filters featuring flexible frequency choice and compact size are proposed using two kinds of resonators.One is based on two pairs of different dimensional slotted ground resonators; another is based on a pair of slotted ground resonators and a microstrip‐stepped impedance resonator. Unlike traditional filters, the harmonics of slotted ground resonators forming the lower passband are tuned to higher frequencies; the resonators forming the lower and upper passband lie at the two sides of signal line, the two passbands can be adjusted to the desired values with expected bandwidth by changing the sizes of the resonators independently. The interactions between them are minor. The proposed filters do not need extra impedance matching network unlike traditional dual‐band filters and with the ground plane efficiently used, they are more compact in structure. Both filters are optimized with jumping genes evolutionary algorithms for multiobjectives, such as low‐insertion loss, suitable bandwidth, and good stopbands. Two optimized bandpass filters were also implemented. Simulation and measurement results are performed to verify their good characteristics. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26028
Enhanced temperature sensitivity of fiber Bragg grating temperature sensor using thermal expansion of copper tube
Authors: Lee Cherl‐Hee , Kim Min‐Kuk , Kim Kwang Tack , Lee Jonghun 
Published: April 2011

AbstractThe temperature sensitivity of fiber Bragg grating (FBG) temperature sensor is enhanced when using a copper tube to jacket of the FBG.Both sides of the FBG are glued with epoxy to cylindrical ferrules tubes that in turn is inserted and glued to a cylindrical copper tube. As the high thermal expansion coefficient of the cylindrical copper tube pulls both sides of the FBG, the temperature sensitivity is improved 3.3‐fold when compared to that of a bare FBG. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26032
Realization of dual band‐notched function for a UWB antenna using hybrid resonators
Authors: He Kai , Sun Bao‐hua , Zhang Fei‐fei , Wang Ya‐fang , Xue Jin‐yuan 
Published: April 2011

AbstractA dual band‐notched planar ultra‐wideband (UWB) monopole antenna using hybrid resonators is presented in this article. By etching a complementary electric‐LC resonator on the ground plane and a split ring resonator on the regular octagon radiation patch, dual band‐notched characteristics are achieved. Details of the antenna design, the radiation pattern and the measured results of voltage standing wave ratio (VSWR) are given. Experimental results demonstrate that the proposed antenna operates over a UWB frequency range from 2.9 to 12.4 GHz for VSWR < 2 while providing dual band‐stop function in the frequency bands of 3.3–3.6 and 5.2–5.8 GHz. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26033
NURBS surfaces modeled locally corrected Nyström method
Authors: Lai Ben , Yuan Hao‐Bo , Liang Chang‐Hong 
Published: April 2011

AbstractThis paper introduce the Nonuniform Rational B‐Spline (NURBS) surfaces to improve the geometric modeling of the Locally Corrected Nyström (LCN) Method.Compared with the interpolation curvilinear quadrilaterals, the NURBS surfaces can approximate the model with higher accuracy and by much less elements. Thus, the size of the elements can be more flexibly chosen to fully exert the efficiency of the LCN method. Numerical results of the radar cross sections (RCS) show the validity of the proposed technique. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26034
Internal mobile phone antenna array for LTE/WWAN and LTE MIMO operations
Authors: Wong Kin‐Lu , Kang Ting‐Wei , Tu Ming‐Fang 
Published: April 2011

AbstractAn antenna array comprising a main antenna for eight‐band LTE/WWAN operation and an auxiliary antenna to combine with the main antenna for LTE MIMO operation in the mobile phone is presented. Both the main and auxiliary antennas are disposed at the bottom edge of the system circuit board of the mobile phone and separated by a protruded ground. The main and auxiliary antennas can respectively fit in two small no‐ground regions of 15 × 30 mm2 and 15 × 20 mm2 on the system circuit board, while the protruded ground in‐between the two antennas has a width of 10 mm for mounting a USB data port. The main antenna covers the 704–960/1710–2690 MHz bands for eight‐band LTE/WWAN operation, and the auxiliary antenna covers the 704–787/2300–2690 MHz bands such that the main and auxiliary antennas together can perform LTE MIMO operation in the LTE700/2300/2500 bands. The proposed antenna array is fabricated and tested. Results are presented and discussed. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26038
All optical half adder/subtractor using dark‐bright soliton conversion control
Authors: Phongsanam P. , Mitatha S. , Teeka C. , Yupapin P.P. 
Published: April 2011

AbstractWe propose a new design of all‐optical circuit using microring and nanoring devices, in which the simultaneous operation of half adder/subtractor arithmetic can be formed by using the dark‐bright soliton conversion control within the system. The input logic “0” and “1” are performed by using dark and bright soliton pulses, respectively. By using the dark‐bright soliton conversion behavior with in the π/2 phase shift device (i.e., an optical coupler), the arithmetic unit can perform simultaneously at the drop‐ and through‐ ports, respectively. In application, the proposed concept can be recognized as a simple and flexible scheme for performing the logic switching system, which can be used for advanced logical system. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26039
Performance enhancement of Salisbury screen absorber using resistively loaded spiral FSS
Authors: Seman F. Che , Cahill R. 
Published: April 2011

AbstractIn this article, we show that the −10 dB reflectivity bandwidth of a Salisbury screen operating at normal incidence is increased by 56% when a lossy spiral shaped frequency selective surface is inserted between the outermost 377 Ω per square resistive sheet and the ground plane. Moreover, this structure exhibits significantly better angular stability and is suitable for suppressing radar backscatter simultaneously in the TE and TM plane. Reflectivity predictions for normal and 40° incidence are shown to be in close agreement with bistatic measured results over the frequency range 5.4–18 GHz. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26040
Design of a 2.5‐GHZ QVCO robust against high frequency substrate noise
Authors: Molina Marc , Gómez Dídac , Aragones Xavier , Mateo Diego , González José Luis 
Published: April 2011

AbstractThis work presents the design procedure followed to obtain a low‐power voltage‐controlled oscillator (VCO) robust against high‐frequency substrate noise, using as a demonstrator a 2.5 GHz VCO with quadrature outputs (QVCO) based on a 5‐GHz LC tank resonant VCO (LC‐VCO) and frequency divider. A simple, intuitive, and easy to handle analytical model is proposed to identify the design parameters that contribute to the performance degradation of LC‐VCOs due to the effect of high frequency substrate noise. The guidelines obtained have been applied in the design of the low‐power QVCO. Finally, the work discusses several trade‐offs that can be used to maximize the immunity of a LC‐VCO against substrate noise. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26043
Triple band RFID reader antenna for handheld applications
Authors: Mobashsher A. T. , Islam M. T. , Misran N. 
Published: April 2011

AbstractA novel compact microstrip antenna is presented for tri‐band RFID applications.The antenna consisting of a monopole like bent arm with a capacitively coupled small patch, printed on the alternative side of the ground plane, which might be common for multi‐layer reader circuitry. By adjusting the dimension of the bent arm as well as the embedded bent and capacitive coupling, tri‐band antenna has obtained in a small profile. The prototyped antenna shows broad impedance bandwidths (10 dB ≤ return loss) of 17.5, 32.7, and 25.5% accordingly in UHF (902–928MHz), 2.45GHz and 5.8GHz RFID bands with stable radiation characteristics. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26044
Design of a miniaturized microstrip dual‐mode dual‐band bandpass filter
Authors: Wang Jianpeng , Ni Jia , Pan Jie‐Bin , Ge Lei , Guo Yong‐Xin 
Published: April 2011

AbstractA miniaturized microstrip dual‐mode dual‐band bandpass filter is presented in this article. The filter is constructed by two slow‐wave dual‐mode resonators and two feed lines. To excite dual‐mode response, each dual‐mode resonator is coupled by an L‐shape feed line. To realize multiple transmission zeroes outside the two passbands, parasitic coupling between two feed lines are also introduced. With these considerations, the proposed dual‐mode dual‐band filter has the properties of compact size, high selectivity, and two transmission poles inside each passband. Demonstrator filter is designed and validated with good agreement between the full‐wave electromagnetic simulations and measurements. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26056
Bidirectional transmission of IEEE 802.11G over colorless WDM‐PON employing a reflective semiconductor optical amplifier
Authors: Avó R. , Guerreiro M. , Medeiros M. C. R. 
Published: April 2011

AbstractThis letter assesses the performance transmission of 802.11g signals over a colorless bidirectional wavelength division multiplexed passive optical network employing a reflective semiconductor optical amplifier. Error‐free operation is demonstrated, for a back‐to‐back configuration with at least 8 dB of optical margin. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26058