bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bridging the Chasm Between Cognitive Representations and Formal Structures of Linguistic Meanings
Authors: Mondal Prakash 
Published: May 2024

AbstractThis paper aims to show that properties of cognitive/conceptual representations and formal‐logical structures of linguistic meaning can be inter‐translated, recast, transformed into one another, and so united together, even though cognitive/conceptual representations and formal‐logical structures of linguistic meaning are apparently distinct in ontology and divergent in their form or character. While cognitive/conceptual representations are ultimately rooted in sensory‐motor systems, formal‐logical structures of linguistic meaning are abstractions detached from and independent of the actualized world. This paper sketches out the foundations of how representations of linguistic meaning in terms of cognitive/conceptual structures in Cognitive/Conceptual Semantics can be unified with those in terms of formal‐logical structures in Formal Semantics. This is done by recasting cognitive/conceptual representations in terms of formal‐logical structures of linguistic meaning and re‐encoding formal‐logical structures of linguistic meaning in terms of cognitive/conceptual representations. Then, these two types of semantic representations, thus shown representationally equivalent, will be related to a series of derivations across levels in neuronal networks and dynamics. The general discussion on unifying cognitive/conceptual representations of linguistic meaning with formal‐logical structures is contextualized within the broader context of theorizing in cognitive science.
The impacts of alcohol marketing and advertising, and the alcohol industry's views on marketing regulations: Systematic reviews of systematic reviews
Authors: Giesbrecht Norman , Reisdorfer Emilene , Shield Kevin 
Published: May 2024

AbstractIssuesAdvertising and marketing affect alcohol use; however, no single systematic review has covered all aspects of how they affect alcohol use, and how the alcohol industry views alcohol marketing restrictions.ApproachTwo systematic reviews of reviews were performed according to the Preferred Reporting Items on 2 February 2023. Results were analysed using a narrative synthesis approach.Key FindingsTwenty‐three reviews were included in the systematic reviews. The first systematic review examined youth and adolescents (11 reviews), digital or internet marketing (3 reviews), alcohol marketing's impact on cognition (3 reviews), and alcohol marketing and policy options (2 reviews). The second systematic review focused on alcohol industry (i.e., importers, producers, distributors, retailers and advertising firms) response to advertising restrictions (four reviews). The reviews indicated that there is evidence that alcohol marketing (including digital marketing) is associated with increased intentions to drink, levels of consumption and harmful drinking among youth and young adults. Studies on cognition indicate that advertisements focusing on appealing contexts and outcomes may be more readily accepted by adolescents, and may be less easily extinguished in this population. The review of the alcohol industry found a strong desire to self‐regulate alcohol advertising.ImplicationsWe found alcohol advertising and marketing is associated with increased drinking intentions, consumption and harmful drinking. Thus, policies which restrict advertising may be an effective way to reduce alcohol use.ConclusionMore research is needed to assess all aspects of the observed associations, especially as to how marketing policies impact women and people with alcohol dependence.
Association of dipeptidyl peptidase‐4 inhibitor initiation at glycated haemoglobin <7.5% with reduced major clinical events mediated by low glycated haemoglobin variability
Authors: Cheung Johnny T. K. , Yang Aimin , Wu Hongjiang , Lau Eric S. H. , Lui Juliana , Kong Alice P. S. , Ma Ronald C. W. , Luk Andrea O. Y. , Chow Elaine , Chan Juliana C. N. 
Published: May 2024

AbstractAimTherapeutic inertia, hypoglycaemia and poor treatment persistence can lead to glycaemic fluctuation and poor outcomes in type 2 diabetes (T2D). We compared glycated haemoglobin (HbA1c) variability, insulin initiation, severe hypoglycaemia and clinical events in patients with T2D initiated dipeptidyl peptidase‐4 inhibitors (DPP4is) at low versus high HbA1c thresholds.MethodsUsing territory‐wide electronic medical records in Hong Kong, we curated a propensity score‐matched cohort of patients initiated DPP4i at HbA1c <7.5% versus ≥7.5% in 2007‐2019. We expressed the HbA1c variability score (HVS) as a proportion of HbA1c varied by ≥0.5% compared with preceding values. We used the Cox model to compare the risks of insulin initiation and clinical outcomes, adjusted for time‐varying variables between the two groups. Mediation analysis estimated the effects of HbA1c variability on outcomes.ResultsAmong 6874 insulin‐naïve patients who initiated DPP4i, 88.7% were treated with metformin and 79.6% with sulphonylureas at baseline (54.9% men; mean age 65.2 ± 11.4 years). After a median follow‐up of 4.6 years, compared with the high‐threshold plus high‐HVS group (≥50%), the low‐threshold plus low‐HVS (<50%) group had reduced hazard ratios (95% confidence interval) of insulin initiation (0.35, 0.31‐0.40), severe hypoglycaemia (0.38, 0.34‐0.44), major adverse cardiovascular endpoints (0.76, 0.66‐0.88), heart failure (0.42, 0.36‐0.49), end‐stage kidney disease (0.65, 0.36‐0.49) and mortality (0.45, 0.35‐0.57). Reduced HbA1c variability explained 31.1%‐81.2% of the effect size of DPP4i initiation at HbA1c <7.5% versus ≥7.5% on outcomes.ConclusionsIn Chinese patients with T2D, avoiding therapeutic inertia with intensified glycaemic control at HbA1c <7.5% using drugs with low risk of hypoglycaemia and good tolerability, such as DPP4i, delayed insulin treatment, reduced HbA1c variability and improved clinical events.
Pandemic distress and anti‐immigration sentiments
Authors: Daniele Gianmarco , Martinangeli Andrea F. M. , Passarelli Francesco , Sas Willem , Windsteiger Lisa 
Published: May 2024

AbstractWe investigate the causal nexus between pandemic distress and anti‐immigration sentiments. We exploit the disruption brought about by the Covid‐19 outbreak to randomly provide survey respondents with information on the economic or health consequences of the pandemic. Overall, we find that pessimistic information about the economic outlook reinforces overall adversity to immigration and the wish to exclude immigrants from access to healthcare. This effect is less pronounced in areas with larger immigrant populations. Our theoretical model pins down two possible mechanisms explaining these results: a zero‐sum game to split scarce public resources between residents and immigrants on the one hand, and on the other, fear of contagion.
The knowledge, attitudes, and practices of arteriovenous access assessment among hemodialysis nurses: A multicenter cross‐sectional survey
Authors: Chen Jingying , Lu Jinghua , Fu Xia , Zhou Hongzhen 
Published: May 2024

AbstractIntroductionHemodialysis nurses' cannulation technique, monitoring, and management methods can affect patients' vascular access longevity. An arteriovenous access assessment comprises a medical history and vascular assessment through physical examination and surveillance. However, further exploration is needed to fully understand hemodialysis nurses' knowledge, attitudes, and practices (KAP) in this area.MethodsBetween June and July 2023, we recruited hemodialysis nurses from 21 cities in Guangdong Province using a convenience sampling method. Four questionnaires—the General Data Questionnaire, the KAP Scale of Arteriovenous Access Assessment among Hemodialysis Nurses, the Utrecht Work Engagement Scale, and the NASA Task Load Index—were utilized for data collection through the Questionnaire Star platform.FindingsOf the 530 hemodialysis nurses participating in the study, 458 (86.4%) had a valid response. The participants demonstrated moderate knowledge and practice levels regarding arteriovenous access assessment and exhibited positive attitudes. We identified several factors related to arteriovenous access assessment that predict KAP in hemodialysis nurses. These factors included years of experience as a hemodialysis nurse, whether a nurse's knowledge of physical examination was sufficient to meet clinical needs, whether a nurse had received training in performing physical examination, whether a nurse's department regularly checked the quality of physical examination, and nurses' levels of work engagement and mental workload. All factors explained 32.4% of the variance in participants' KAP regarding arteriovenous access assessment.DiscussionImproving hemodialysis nurses' assessment of arteriovenous access is crucial to ensure optimal patient care. Dialysis center managers and educators should prioritize understanding hemodialysis nurses' KAP of arteriovenous access assessment and any factors influencing these areas.
Hemodynamic effects of low versus high dialysate bicarbonate concentration in hemodialysis patients
Authors: Jensen Jonas Schandorph Kaalund , Jørgensen Ina Hunnerup , Buus Niels Henrik , Jensen Jens Dam , Peters Christian Daugaard 
Published: May 2024

AbstractIntroductionHemodialysis treatment using standard dialysate bicarbonate concentrations cause transient metabolic alkalosis possibly associated with hemodynamic instability. The aim of this study was to perform a detailed comparison of high and low dialysate bicarbonate in terms of blood pressure, intradialytic hemodynamic parameters, orthostatic blood pressure, and electrolytes.MethodsFifteen hemodialysis patients were examined in a single‐blind, randomized, controlled, crossover study. Participants underwent a 4‐h hemodialysis session with dialysate bicarbonate concentration of 30 or 38 mmol/L with 1 week between interventions. Blood pressure was monitored throughout hemodialysis, while cardiac output, total peripheral resistance, stroke volume, and central blood volume were assessed with ultrasound dilution technique (Transonic). Orthostatic blood pressure was measured pre‐ and post‐hemodialysis.FindingsWith similar ultrafiltration (UF) volume (2.6 L), systolic blood pressure (SBP) tended to decrease more during high dialysate bicarbonate compared to low dialysate bicarbonate; the mean (95% confidence interval) between treatment differences in SBP were: 8 (−4; 20) mmHg (end of hemodialysis) and 7 (0; 15) mmHg (post‐hemodialysis). Stroke volume decreased whereas total peripheral resistance increased significantly more during high dialysate bicarbonate compared to low dialysate bicarbonate with mean between treatment differences: Stroke volume: 12 (1; 23) mL; Total peripheral resistance: −2.9 (−5.3; −0.5) mmHg/(L/min). Cardiac output tended to decrease more with high dialysate bicarbonate compared to low dialysate bicarbonate with mean between treatment difference 0.7 (0.0; 1.4) L/min. High dialysate bicarbonate caused alkalosis, hypocalcemia, and lower plasma potassium, whereas patients remained normocalcemic with normal pH during low dialysate bicarbonate. Orthostatic blood pressure response after dialysis did not differ significantly.DiscussionThe use of high dialysate bicarbonate compared to low dialysate bicarbonate was associated with hypocalcemia, alkalosis, and a more pronounced hypokalemia. During hemodialysis with UF, a better preservation of blood pressure, stroke volume, and cardiac output may be achieved with low dialysate bicarbonate compared to high dialysate bicarbonate.
Icariin alleviates oxygen‐induced retinopathy by targeting microglia hexokinase 2
Authors: Li Xingran , Wang Guoqing , Li Na , Wang Xiaotang , Fan Wei , Zhang Zhi , Li Wanqian , Liu Jiangyi , Huang Jiaxing , Liu Xianyang , Zhou Qian , Hou Shengping 
Published: May 2024

AbstractRetinopathy of prematurity (ROP) is a retinal disease‐causing retinal neovascularization that can lead to blindness. Oxygen‐induced retinopathy (OIR) is a widely used ROP animal model. Icariin (ICA) has anti‐oxidative and anti‐inflammation properties; however, whether ICA has a regulatory effect on OIR remains unclear. In this study, ICA alleviated pathological neovascularization, microglial activation and blood–retina barrier (BRB) damage in vivo. Further results indicated that endothelial cell tube formation, migration and proliferation were restored by ICA treatment in vitro. Proteomic microarrays and molecular mimicry revealed that ICA can directly bind to hexokinase 2 (HK2) and decrease HK2 protein expression in vivo and in vitro. In addition, ICA inhibited the AKT/mTOR/HIF1α pathway activation. The effects of ICA on pathological neovascularization, microglial activation and BRB damage disappeared after HK2 overexpression in vivo. Similarly, the endothelial cell function was revised after HK2 overexpression. HK2 overexpression reversed ICA‐induced AKT/mTOR/HIF1α pathway inhibition in vivo and in vitro. Therefore, ICA prevented pathological angiogenesis in OIR in an HK2‐dependent manner, implicating ICA as a potential therapeutic agent for ROP.
Robust optimization model for relief supplies distribution considering fairness
Authors: Chen Yingzhen 
Published: May 2024

AbstractThe emergency management agency (EMA) needs to distribute limited relief supplies efficiently. However, it is difficult to develop a reliable system for relief supplies distribution owing to the uncertainties in emergencies. This paper investigates a robust multiperiod relief supplies distribution problem that considers the uncertainties of transportation time, the amount of donation amount, and the secondary disasters. First, a satisfaction model is constructed by considering the relief supplies and the transportation time. The negative effect of the delay in transportation time is considered in the satisfaction model. Second, based on the satisfaction model, a comprehensive fairness strategy is constructed that considers both vertical fairness and horizontal fairness. Finally, a relief supplies distribution model is built for the EMA that considers the actions of the non‐governmental organization (NGO) and donors. Both the utility and the fairness are considered in the objective of the proposed model. In numerical experiments, the Wenchuan earthquake is conducted to illustrate the applicability of the model and provide implications for decision‐makers. The results show the benefits of considering both vertical fairness and horizontal fairness. Then the suitable threshold is given by the analysis of the time delay. Finally, managerial insights and recommendations for the EMA and the NGO derived from the numerical experiments are presented. The findings in this paper help improve the reliability of the relief supplies distribution system.
All‐cause and cause‐specific mortality in US adults with periodontal diseases: A prospective cohort study
Authors: Larvin Harriet , Baptiste Paris J. , Gao Chenyi , Muirhead Vanessa , Donos Nikolaos , Pavitt Sue , Kang Jing , Wu Jianhua 
Published: May 2024

AbstractAimThis prospective cohort study investigated the association between periodontal diseases (PDs) and all‐cause and cause‐specific mortality.Materials and MethodsWe utilized adult participants recruited from six National Health and Nutrition Examination Survey cycles (1999–2014) and linked mortality data from the National Death Index up to December 2019. Baseline clinical periodontal examinations were performed by trained and calibrated examiners. All‐cause and cause‐specific mortality was modelled through multivariable Cox proportional hazards and Fine–Gray models to account for competing risks. All models were adjusted for demographic and lifestyle variables, clinical measurements and comorbidities.ResultsOverall, 15,030 participants were included, with a median length of follow‐up of 9 years. Risk of all‐cause mortality was 22% greater in people with PD than the control group (adjusted hazard ratio [HR]: 1.22, 95% confidence interval [CI]: 1.12–1.31). Risks of mortality by cardiovascular diseases (CVD), respiratory disease and diabetes were highest in participants with severe PD (CVD—sub‐distribution HR [SHR]: 1.38, 95% CI: 1.16–1.64; respiratory—SHR: 1.62, 95% CI: 1.07–2.45; diabetes—SHR: 1.68, 95% CI: 1.12–2.53).ConclusionsSevere PD is associated with all‐cause and cause‐specific mortality among US adults after multivariable adjustment.
Natural products and diet for the prevention of oral cancer: Research from south and southeast Asia
Authors: Malathi N. , Rajan Sharada T. , Warnakulasuriya Saman 
Published: May 2024

AbstractMedicinal plants are of prime importance in the discovery of drugs. They are an inherent source of naturally available phytochemicals that can help in the prevention and treatment of several diseases including cancer. This article reviews the experimental and clinical evidence of phytochemicals available in natural dietary products that are used in everyday life across South Asia and South‐East Asia for their perceived effectiveness in the management of Potentially Malignant Disorders and prevention of Oral Cancer. The review also highlights the active phytometabolites, their in vitro anti‐proliferative properties and targeted signalling pathways, biological activities in in vivo models and translative potential for clinical trials in humans.
Water deprivation modifies the metabolic profile of lavender (Lavandula angustifolia Mill.) leaves
Authors: Liao Zhengqiao , Liu Lei , Rennenberg Heinz , Du Baoguo 
Published: May 2024

AbstractLavender plantation is globally expanded due to the increasing demand of its essential oil and its popularity as an ornamental species. However, lavender plantations, and consequently essential oil industries, are threatened by more frequent and severe drought episodes in a globally changing climate. Still little is known about the changes in the general metabolome, which provides the precursors of essential oil production, by extended drought events. Prolonged drought fundamentally results in yield losses and changing essential oil composition. In the present study, the general metabolome of a main cultivated lavender species (Lavandula angustifolia Mill.) in response to water deprivation (WD) and re‐watering was analyzed to identify the metabolomics responses. We found prolonged WD resulted in significant accumulations of glucose, 1,6‐anhydro‐β‐D‐glucose, sucrose, melezitose and raffinose, but declines of allulose, β‐D‐allose, altrose, fructose and D‐cellobiose accompanied by decreased organic acids abundances. Amino acids and aromatic compounds of p‐coumaric acid, hydrocaffeic acid and caffeic acid significantly accumulated at prolonged WD, whereas aromatics of cis‐ferulic acid, taxifolin and two fatty acids (i.e., palmitic acid and stearic acid) significantly decreased. Prolonged WD also resulted in decreased abundances of polyols, particularly myo‐inositol, galactinol and arabitol. The altered metabolite profiles by prolonged WD were mostly not recovered after re‐watering, except for branched‐chain amino acids, proline, serine and threonine. Our study illustrates the complex changes of leaf primary and secondary metabolic processes of L. angustifolia by drought events and highlights the potential impact of these precursors of essential oil production on the lavender industry.
Effect of continuous positive airway pressure helmet on respiratory function following surgical procedures in brachycephalic dogs: A randomized controlled trial
Authors: Araos Joaquin , Hayes Galina M. , Nugen Sarah A. , Lao Derek , Fredericks Carol E. , King Andrea L. , Martin‐Flores Manuel 
Published: May 2024

AbstractObjectiveTo evaluate the effect of continuous positive airway pressure (CPAP) on respiratory function in the early postoperative period of brachycephalic dogs.Study designProspective, randomized clinical trial.AnimalsA total of 32 dogs.MethodsDogs were assigned to recover with or without CPAP (control) and assessed at specific time points over 1 h. Treatment was discontinued for dogs with a CPAP tolerance score of 3 or more (from a range of 0–4). The primary outcome was pulse oximetry (SpO2). Secondary outcomes were arterial O2 pressure (PaO2)/FiO2 ratio (PaO2/FiO2), arterial CO2 pressure (PaCO2), and rectal temperature. For dogs that reached a CPAP tolerance score of 3 or more, only the data collected up to the time point before discontinuation were included in the analysis. The treatment effect (β) was analyzed using random effects models and the results were reported with 95% confidence intervals.ResultsDogs were assigned randomly to each protocol. Baseline characteristics in both groups were comparable. Arterial blood gases were obtained in seven control group dogs and nine CPAP group dogs. Treatment did not affect SpO2 (β = −0.1, −2.1 to 2.0) but affected the PaO2/FiO2 ratio (β = 58.1, 2.6 to 113.6), with no effects on PaCO2 (β = −4.3, −10.5 to 1.9) or temperature (β = 0.4, −0.8 to 1.6).ConclusionIn postoperative brachycephalic dogs, CPAP had no effect on SpO2 but improved the PaO2/FiO2 ratio in brachycephalic dogs postoperatively.Clinical significanceContinuous positive airway pressure offers a valuable solution to improve gas exchange efficiency, a prevalent concern in postoperative brachycephalic dogs, with the potential to enhance overall outcomes.
On functional successive minima
Authors: Amoroso F. , Masser D. , Zannier U. 
Published: May 2024

AbstractIn the classical Geometry of Numbers, the calculation of successive minima may be quite difficult, even in using the norm coming from a distance function associated to a set. In the literature, there seem to be hardly any analogues when is replaced by the algebraic closure of a function field in one variable and one uses a norm arising from the absolute height. Here, we calculate a one‐parameter family of examples that naturally arose in our recent paper on bounded heights. We also comment on whether the minima are attained.
Septic arthritis of the native hip joint and septic pulmonary embolism in an adult with sickle cell trait after a complicated dental extraction
Authors: Ayogu Chukwudi Isaac , Valluru Balakrishna 
Published: May 2024

Septic arthritis (SA) is a serious infection of the joint which can lead to irreversible destruction of the joint.We report a case of right hip SA with septic pulmonary embolism following a complicated dental extraction in a woman in her early 40s with sickle cell trait (SCT).The patient presented with severe right thigh pain and left jaw pain.Initial workup revealed raised C reactive protein and positive blood cultures. Right hip joint SA was confirmed following intraoperative joint aspiration. The patient had right hip debridement with long-term intravenous antibiotics.The incidence of SA in adults with sickle cell disease is low: 0.3% in a study in France and Brazil and 10.3% incidence of haematogenous osteoarticular infection in children with SCT in West Africa.