bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex Differences in Human Brain Structure at Birth
Authors: Khan Yumnah T. , Tsompanidis Alex , Radecki Marcin A. , Dorfschmidt Lena ,   APEX Consortium, Austin Topun , Suckling John , Allison Carrie , Lai Meng-Chuan , Bethlehem Richard A. I. , Baron-Cohen Simon 
Published: June 2024

AbstractSex differences in human brain anatomy have been well-documented; however, their underlying causes remain controversial. Neonatal research offers a pivotal opportunity to address this long-standing debate. Given that postnatal environmental influences (e.g., gender socialisation) are minimal at birth, any sex differences observed at this stage can be more readily attributed to prenatal influences. Here, we assessed on-average sex differences in global and regional brain volumes in 514 newborns (236 birth-assigned females and 278 birth-assigned males) using data from the developing Human Connectome Project. On average, males had significantly larger intracranial and total brain volumes, even after controlling for birth weight. After controlling for total brain volume, females showed higher total cortical gray matter volumes, whilst males showed higher total white matter volumes. After controlling for total brain volume in regional comparisons, females had increased white matter volumes in the corpus callosum and increased gray matter volumes in the bilateral parahippocampal gyri (posterior parts), left anterior cingulate gyrus, bilateral parietal lobes, and left caudate nucleus. Males had increased gray matter volumes in the right medial and inferior temporal gyrus (posterior part) and right subthalamic nucleus. Effect sizes ranged from small for regional comparisons to large for global comparisons. While postnatal experiences likely amplify sex differences in the brain, our findings demonstrate that several global and regional on-average sex differences are already present at birth.
High resolution profiling of cell cycle-dependent protein and phosphorylation abundance changes in non-transformed cells
Authors: Rega Camilla , Tsitsa Ifigenia , Roumeliotis Theodoros I. , Krystkowiak Izabella , Portillo Maria , Yu Lu , Vorhauser Julia , Pines Jonathon , Mansfeld Joerg , Choudhary Jyoti , Davey Norman E. 
Published: June 2024

AbstractThe cell cycle governs a precise series of molecular events, regulated by coordinated changes in protein and phosphorylation abundance, that culminates in the generation of two daughter cells. Here, we present a proteomic and phosphoproteomic analysis of the human cell cycle in hTERT-RPE-1 cells using deep quantitative mass spectrometry by isobaric labelling. Through analysing non-transformed cells, and improving the temporal resolution and coverage of key cell cycle regulators, we present a dataset of cell cycle-dependent protein and phosphorylation site oscillation that offers a foundational reference for investigating cell cycle regulation. These data reveal uncharacterised regulatory intricacies including proteins and phosphorylation sites exhibiting previously unreported cell cycle-dependent oscillation, and novel proteins targeted for degradation during mitotic exit. Integrated with complementary resources, our data link cycle-dependent abundance dynamics to functional changes and are accessible through the Cell Cycle database (CCdb), an interactive web-based resource for the cell cycle community.
HARMONY (HARM reduction for Opiates, Nicotine and You) Trial: Protocol of a Randomised Controlled Trial of the Effectiveness of Vaporised Nicotine Products for Tobacco Smoking Cessation amongst NSW Opiate Agonist Treatment Clients
Authors: Bonevski B , Jackson M , Austin E , Lintzeris N , Ezard N , Gartner C , Oldmeadow C , Haber P , Hallinan R , Rodgers C , Ho T , Nean M , Harrod M , Dunlop A 
Published: June 2024

ABSTRACTIntroductionTobacco smoking is a major cause of preventable disease in Australia. Individuals receiving opiate agonist treatment (OAT) are a group who experience high tobacco-related morbidity and mortality rates. Despite reporting a desire to stop, relapse rates in OAT clients are high and cessation attempts supported by pharmacotherapy are less effective than in general populations. New and innovative ways of addressing smoking amongst this group are needed.Vaporised nicotine products (VNPs), or e-cigarettes, may reduce a person’s exposure to toxicants and carcinogens when compared to tobacco cigarettes. High quality evidence indicates that VNPs can increase rates of smoking cessation compared to nicotine replacement therapy. Pilot results of VNPs as a smoking cessation aid in OAT clients suggests their use is feasible and acceptable but effectiveness in this group has not been explored.This protocol details the rationale and methodology for a randomised controlled trial to examine the effectiveness of VNPs for tobacco smoking cessation amongst OAT clients in New South Wales, Australia.Methods and AnalysisThis will be a randomised single-blinded parallel group trial comparing 12-weeks of 12mg/mL vaporised nicotine to best-practice NRT. Participants must be 18 years or older, accessing opiate treatment at a participating health site, and a current daily tobacco smoker seeking to quit or reduce their smoking.The primary outcome will be self-reported 7-day point prevalence abstinence from tobacco after 12-weeks of treatment. Secondary outcomes include biochemically verified abstinence, self-reported 30-day abstinence, number of cigarettes smoked each day, craving and withdrawal symptoms, and VNP safety. Between-group comparisons will be conducted at end of treatment, and at 12-weeks post-treatment.DiscussionThis study examines new ways of reducing tobacco related harm in individuals receiving OAT. Outcomes may be enhanced by leveraging participants interactions with health care provides who can facilitate the required support. Study findings have the potential to significantly impact tobacco smoking prevalence in priority populations.Ethics and DisseminationProtocol approval was granted by Hunter New England Human Research Ethics Committee (Reference 2020/ETH01866). Findings will be disseminated via academic conferences, peer-reviewed publications and social media.RegistrationThe study was registered in the Australian New Zealand Clinical Trials Registry (Reference ACTRN12621000148875).
Effect of intravenous lidocaine dose on pain upon awakening in pediatric tonsillectomy: A randomized trial
Authors: Hu Yang , Du Ming-Cheng , Chen Yi , Long Xiang , Jiang Jing-Jing , Gong Yuan 
Published: June 2024

AbstractWe investigated the potential of intravenous lidocaine to reduce pain on awakening in a dose- dependent manner and aimed to determine the median effective dose of lidocaine in 200 children aged 3–12 years (American Society of Anesthesiologists physical status I–II) who underwent elective tonsillectomy with or without adenoidectomy at Yichang Central People’s Hospital. The patients were randomized into four dose groups (A–D: 0.0, 1.0, 1.5, and 2.0 mg/kg, respectively), and they underwent the same anesthetic induction and maintenance protocols. The primary outcome was pain on awakening, while secondary outcomes included pain scores at 1, 4, 12, and 24 h after awakening; incidences of laryngospasm, bronchospasm, or perioperative stridor; and time to extubation. Intraoperative cardiac events were classified as safety events. Our findings indicated that intravenous lidocaine dose-dependently reduced pain on awakening, with the median effective dose being 1.75 mg/kg. Significant differences were observed between groups A and D (P ≤ 0.001). No incidents of laryngospasm, bronchospasm, or perioperative stridor were observed. Furthermore, there were significant between-group differences in time to extubation (P ≤ 0.05). In conclusion, our study demonstrated that lidocaine dose-dependently reduced pain on awakening in children undergoing tonsillectomy with or without adenoidectomy, with no severe adverse events.
Evolution of the Umbilical Cord Blood Proteome Across Gestational Development
Authors: Mithal Leena B. , Lancki Nicola , Ling-Hu Ted , Goo Young Ah , Otero Sebastian , Rhodes Nathaniel J. , Cho Byoung-Kyu , Grobman William A. , Hultquist Judd F. , Scholtens Denise , Mestan Karen G. , Seed Patrick C. 
Published: June 2024

AbstractNeonatal health is dependent on early risk stratification, diagnosis, and timely management of potentially devastating conditions, particularly in the setting of prematurity. Many of these conditions are poorly predicted in real-time by clinical data and current diagnostics. Umbilical cord blood may represent a novel source of molecular signatures that provides a window into the state of the fetus at birth. In this study, we comprehensively characterized the cord blood proteome of infants born between 24 to 42 weeks using untargeted mass spectrometry and functional enrichment analysis. We determined that the cord blood proteome at birth varies significantly across gestational development. Proteins that function in structural development and growth (e.g., extracellular matrix organization, lipid particle remodeling, and blood vessel development) are more abundant earlier in gestation. In later gestations, proteins with increased abundance are in immune response and inflammatory pathways, including complements and calcium-binding proteins. Furthermore, these data contribute to the knowledge of the physiologic state of neonates across gestational age, which is crucial to understand as we strive to best support postnatal development in preterm infants, determine mechanisms of pathology causing adverse health outcomes, and develop cord blood biomarkers to help tailor our diagnosis and therapeutics for critical neonatal conditions.
Prevalence and determinants of food insecurity among households headed by mothers who are female sex workers in three African Countries: Validation and application of food insecurity experience scale
Authors: Weerasinghe Swarna D.S. , Jackson Jennifer A. , Stadler Diane D. , Macias-Konstantopoulos Wendy L. , Wills Brian 
Published: June 2024

AbstractReduction in prevalence of food insecurity, a key factor in reaching the United Nations Sustainable Development Goal 2.2, was challenged by COVID-19 lockdowns in low- and middle-income countries, which impacted the affordability and accessibility of food. Prevalence and determinants of food insecurity among female sex workers who are mothers (FSWM) and heads of households (FSWM-HH) in the African region have not been previously assessed. This study validated the food insecurity experience scale (FIES) using data collected from 852 FSWM-HH living in the Democratic Republic of the Congo (DRC), Kenya, or Nigeria. Results were calibrated on the global metric to compare with the country-level prevalence of household severe food insecurity (HSFI). Associated individual and household determinants and their intersections were examined to identify vulnerable sub-groups. The FIES reliably assessed (fit index=0.75) household food insecurity among FSWM-HH using a 7-item scale, omitting the item of being worried about not having enough food to eat. The prevalence of HSFI was 59.6% in the DRC, 77.8% in Kenya, and 89.0% in Nigeria and compared to FAO 2016-2018 country levels, 1.5, 3.0, and 4.5 times higher, respectively, than previous estimates. Determinants of HSFI among FSWM-HH were similar to the African region, except FSWM-HH composition of children, but the magnitudes of odds were higher. Multiple logistic regression revealed important ecological relationships. FSWM-HH with 0-3 children living with them (AOR=1.63,95% CI:1.13-2.37, reference>4 children) and mothers having no schooling or primary education (AOR=1.92,95% CI:1.33-2.78, reference with higher education) significantly determined HSFI. Prevalence of HSFI was highest among two subgroups of FSWM-HH: those>30 years of age, without partners (93.7%, p=0.002) and those with low levels of education with 0-3 children living with them (85%, p=0.03). Food programs and welfare policies may be effective strategies to reduce HSFI among this high-risk group of mothers with children.
Gravitational waveforms: A tale of two formalisms
Authors: Bini Donato , Damour Thibault , De Angelis Stefano , Geralico Andrea , Herderschee Aidan , Roiban Radu , Teng Fei 
Published: June 2024

We revisit the quantum-amplitude-based derivation of the gravitational waveform emitted by the scattering of two spinless massive bodies at the third order in Newton’s constant, h∼G+G2+G3 (one-loop level), and correspondingly update its comparison with its classically derived multipolar-post-Minkowskian counterpart. A spurious-pole-free reorganization of the one-loop five-point amplitude substantially simplifies the post-Newtonian expansion. We find complete agreement between the two results up to the fifth order in the small velocity expansion after taking into account three subtle aspects of the amplitude derivation: (1) in agreement with [A. Georgoudis , ], the term quadratic in the amplitude in the observable-based formalism [D. A. Kosower , ] generates a frame rotation by half the classical scattering angle; (2) the dimensional regularization of the infrared divergences of the amplitude introduces an additional (d−4)/(d−4) finite term; and (3) zero-frequency gravitons are found to contribute additional terms both at order h∼G1 and at order h∼G3 when including disconnected diagrams in the observable-based formalism.

Published by the American Physical Society
2024
Interactive effects of market orientation, innovation orientation and sales control systems on firm performance in B2B markets
Authors: Aydin Ugur Burak , Alniacik Umit 
Published: June 2024

PurposeThis study examines the interaction between sales control systems and firm level strategic orientations and their joint effects on company performance in B2B context. Independent and joint effects of market orientation (MO), innovation orientation (IO) and sales control systems (SCS) on firm performance were analyzed.Design/methodology/approachA quantitative research methodology is adopted to compile firm-level primary data from manufacturing companies located in an organized industrial zone. Research data were collected by face-to-face surveys from 302 sales professionals. The research model and hypotheses were tested by using partial least squares (PLS) structural equation modeling (SEM) with Smart PLS 3.0.FindingsIn addition to confirming the positive effects of MO and IO on performance, data analyses revealed that SCS exert an indirect effect on company performance which is fully mediated by MO.Research limitations/implicationsThe research was limited to a developing country context and research data was collected from a convenient sample of B2B companies by a cross-sectional study. Cross-cultural and longitudinal studies may provide additional insights. Firm level strategic orientations and sales control systems must be examined together in an integrated way to explore their effects on company performance. The individual effects of these structures on business performance may manifest differently when they come together.Practical implicationsResults indicate that the sales control system setup is critical for the implementation of a market-oriented strategy. This study highlights the importance of setting a compatible sales control system to achieve organizational goals in accordance with the strategic orientations which affect the success of particular organizational strategies.Originality/valueAlthough the current literature identifies the independent and joint effects of market orientation and innovation orientation on company performance, empirical studies probing the interaction of sales control systems with these constructs is very scarce. Understanding how sales control systems relate to strategic orientations will help design a more effective sales organization and improve company performance. This study contributes to the literature by promoting additional insights by linking sales control systems with market orientation, innovation orientation and company performance.
Spatial–temporal evaluation of total-factor energy efficiency in Chinese construction industry based on three-stage super-efficiency SBM-DEA model
Authors: Shi Qianqian , Wang Ziyu 
Published: June 2024

PurposeThe study aims to enhance energy efficiency within the high-energy consuming construction industry. It explores the spatial-temporal dynamics and distribution patterns of total factor energy efficiency (TFEE) across China’s construction industry, aiming to inform targeted emission reduction policies at provincial and city levels.Design/methodology/approachUtilizing a three-stage super-efficiency SBM-DEA model that integrates carbon emissions, the TFEE in 30 Chinese provinces and cities from 2004 to 2019 is assessed. Through kernel density estimation and exploratory spatial data analysis, the dynamic evolution and spatial patterns of TFEE are examined.FindingsAnalysis reveals that environmental investments positively impact TFEE, whereas Gross Regional Product (GRP) exerts a negative influence. R&D expenditure intensity and marketization show mixed effects. Excluding environmental and random factors, TFEE averages declined, aligning more closely with actual development trends, showing a gradual decrease from east to west. TFEE exhibited fluctuating growth with a trend moving from inefficient clusters to a more even distribution. Spatially, TFEE demonstrated aggregation effects and characteristics of space-time transition.Originality/valueThis research employs the three-stage super-efficiency SBM-DEA model to measure the total factor energy efficiency of the construction industry, taking into account external environment, random disturbances, and multiple effective decision-making units. It also evaluates energy efficiency changes before and after removing disturbances and comprehensively examines regional and temporal differences from static and dynamic, overall and phased perspectives. Additionally, Moran scatter plots and LISA cluster maps are used to objectively analyze the spatial agglomeration and factors influencing energy efficiency.
“I love your brand! I engage with you, and I do online brand-related activities (COBRAs)”: the role of brand value
Authors: Castro-González Sandra , Bande Belén , Fernández-Ferrín Pilar 
Published: June 2024

PurposeFew studies have explained how and when consumers are willing to engage in online brand-related activities (COBRAs). This study examines the role of brand love in a consumer’s decision to engage in online brand-related activities, considering the mediating effect of attitudinal brand engagement and the moderating effect of brand value on this relationship.Design/methodology/approachThe study analysed data from 404 Spanish consumers using structural equation modelling and the PROCESS package in SPSS to test hypotheses, including mediation and moderation effects.FindingsThe study expands on previous research by revealing the mediating role of brand attitudinal engagement in the relationship between brand love and COBRAs and the moderating role of brand value in the relationship between brand engagement and COBRAs. The results show that online consumers who feel brand love from an online store are likelier to be engaged with the brand. This predisposes them to comment on, share, and create content related to the company or brand. Furthermore, consumers who attribute a high value to the brand are likelier to engage in brand-related online activities.Originality/valueThis study offers valuable insights into mechanisms to encourage consumers to generate content, known as user-generated content, to the extent that the tools for developing this content are the same.
If you are different, you are inferior: how does ethnocentric behaviour disengage employees?
Authors: Khan Mehedi Hasan , Jin Jiafei 
Published: June 2024

Purpose
This study advances ethnocentric behaviour research by exploring its impact on individuals' work disengagement in multicultural work settings. Ethnocentrism research focused mainly on consumer ethnocentric behaviour but did not consider the role of employees’ ethnocentric behaviour in the multicultural workplace. This study aims to address this gap by utilizing social identity theory. The authors propose that ethnocentric behaviour has an impact on employee work disengagement and also affects social undermining and workplace conflict as an outcome.

Design/methodology/approach
This study used cross-sectional data (N = 326) collected from employees working for Chinese multinational firms in Bangladesh. The authors used Likert-type scale to collect data. To check the hypothesis, the authors employed Hayes' PROCESS macro 4.0v.

Findings
The authors found that employee ethnocentric behaviour positively impacts workers' work disengagement. Ethnocentric behaviour positively affects social undermining and workplace conflict, whereas social undermining and workplace conflict partially mediate the indirect effects of ethnocentrism on work disengagement. The authors also found that core self-evaluation (CSE) weakens the indirect impact of ethnocentrism on work disengagement through social undermining and workplace conflict.

Practical implications
The authors recommend that organizations recruit employees with positive CSE and provide cultural sensitivity training to reduce ethnocentrism in the culturally diverse workplace.

Originality/value
This study is a unique effort to examine the influence of employees’ ethnocentric conduct by employing social identity theory in the emerging economy subsidiaries of multinational businesses operating in developing countries. This study also addressed the moderating effect of employees' CSE. This adds a unique dimension to ethnocentrism and employee work disengagement research. The authors have also discussed the future research avenue, theoretical and practical implications in detail.
Examining the impact of intra-industry trade on business cycle alignment within the ECOWAS
Authors: Diendere Louis-Joel Basneouinde , Diendere Achille Augustin , Eggoh Jude 
Published: June 2024

Purpose
This paper aims to examine the impact of intra-industry trade on business cycle synchronization within the Economic Community of West African States (ECOWAS). ECOWAS region is characterized by limited intracommunity trade and a low level of foreign direct investment.

Design/methodology/approach
First, this research uses the two-digit level harmonized system classification to measure intra-industry trade, which is straightforward to interpret and compute, making it suitable for countries with low trade intensity. Second, it uses the system generalized method of moments (system-GMM) to examine the dynamic relationship between variables and address endogeneity concerns.

Findings
The results obtained from the system-GMM estimation reveal a positive and significant correlation between intra-industry trade intensity and business cycle synchronization, as well as an inhibiting effect of economic freedom on the relationship between intra-industry trade and business cycle synchronization. These results highlight the need to implement policies aimed at reducing tariff barriers, improving financial integration and intensifying production.

Originality/value
This research analyze the link between intra-industry trade and business cycle synchronization within the ECOWAS. It also analyze the role of economic freedom on the link between intra-industry trade and business cycle synchronization.