bluuebunny/crossref_metadata_2025_split huggingface dataset:
N-glycosylation of Wnt3 regulates the progression of hepatocellular carcinoma by affecting Wnt/β-catenin signal pathway
Authors: Zhang Xin-Zhan , Mo Xiao-Chuan , Wang Zhu-Ting , Sun Rong , Sun Da-Quan 
Published: June 2024

BACKGROUND
Wnt/FZD-mediated signaling pathways are activated in more than 90% of hepatocellular carcinoma (HCC) cell lines. As a well-known secretory glycoprotein, Wnt3 can interact with FZD receptors on the cell surface, thereby activating the Wnt/β-catenin signaling pathway. However, the N-glycosylation modification site of Wnt3 and the effect of this modification on the biological function of the protein are still unclear.
AIM
To investigate the effect of Wnt3 N-glycosylation on the biological function of HCC cells.
METHODS
Site-directed mutagenesis was used to verify the Wnt3 N-glycosylation sites, actinomycin D treatment was used to detect the stability of Wnt3 after site-directed mutation, the binding of the N-glycosylation site-directed mutant Wnt3 to FZD7 was observed by laser confocal microscopy, and the effects of the N-glycosylation site-directed mutation of Wnt3 on the Wnt/β-catenin signaling pathway and the progression of HCC cells were detected by western blot and cell function experiments.
RESULTS
Wnt3 has two N-glycosylation-modified sites (Asn90 and Asn301); when a single site at amino acid 301 is mutated, the stability of Wnt3 is weakened; the binding ability of Wnt3 to FZD7 decreases when both sites are mutated simultaneously; and the level of proteins related to the Wnt/β-catenin signaling pathway is downregulated. Cell proliferation, migration and invasion are also weakened in the case of single 301 site and double-site mutations.
CONCLUSION
These results indicate that by inhibiting the N-glycosylation of Wnt3, the proliferation, migration, invasion and colony formation abilities of liver cancer cells can be weakened, which might provide new therapeutic strategies for clinical liver cancer in the future.
Balloon dilation of congenital perforated duodenal web in newborns: Evaluation of short and long-term results
Authors: Marakhouski Kirill , Malyshka Elena , Nikalayeva Katsiaryna , Valiok Larysa , Pataleta Aleh , Sanfirau Kiryl , Svirsky Aliaksandr , Averin Vasily 
Published: June 2024

BACKGROUND
Incomplete congenital duodenal obstruction (ICDO) is caused by a congenitally perforated duodenal web (CPDW). Currently, only six cases of balloon dilatation of the PDW in newborns have been described.
AIM
To present our experience of balloon dilatation of a perforated duodenal membrane in newborns with ICDO.
METHODS
Five newborns who underwent balloon dilatation of the CPDW along a preinstalled guidewire between 2021 and 2023 were included. Nineteen newborns diagnosed with ICDO who underwent laparotomy were included in the control group.
RESULTS
In all cases, good anatomical and clinical results were obtained. In three cases, a follow-up study was conducted after 1 year. The average time to start enteral feeding per os was significantly earlier in the study group (4.4 d) than in the laparotomic group (21.2 days; P < 0.0001). The time spent by patients in the intensive care unit and hospital after balloon dilatation was also significantly shorter. We determined the selection criteria for possible and effective CPDW balloon dilatation in newborns as follows: (1) Presence of dynamic radiographic signs of the passage of a radiopaque substance beyond the zone of narrowing or radiographic signs of pneumatisation of the duodenum and small bowel distal to the web; (2) presence of endoscopic signs of CPDW; (3) successful cannulation with a guidewire performed parallel to the endoscope, with holes in the congenital duodenal web; and (4) successful positioning of the balloon performed along a freestanding guidewire on the web.
CONCLUSION
Strictly following selection criteria for newborns with ICDO caused by CPDW ensures that endoscopic balloon dilatation using a pre-installed guidewire is safe and effective and shows good 1-year follow-up results.
Autistic Student Teacher’s Pedagogical Competence in the English Language Teaching
Authors: Saputri Tiyas , Anam Syafiul , Munir Ahmad 
Published: June 2024

Objective: This study aims to investigate the autistic student teacher’s pedagogical competence in the English Language Teaching (ELT) practicum based on eight teaching skills, the difficulties he faced, and the strategies to support the autistic student teacher applying his pedagogical competence in the ELT. Method: The method used was a descriptive qualitative with a case study approach. Data collection techniques used in this study were observation, interview, and video recording. Data analysis techniques were dividing observational field notes, doing data reduction, describing and identifying the activity of the autistic student teacher applying his pedagogical competence in the ELT practicums based on the eight teaching skills, and making a conclusion. Results: The results of the study indicated that the autistic student teacher’s pedagogical competence in English Language Teaching based on the eight teaching skills in the eighth grade of inclusion class at 39 Junior High School Surabaya was good, although it was not successfully completed. It was obtained that he only did five to eight teaching skills. He had only skills in questioning, doing reinforcement, doing variation, explaining, opening and closing the class. Three teaching skills had yet to be fully mastered by him. The difficulties faced by him were classroom management, small group discussion and organizing small group discussion and individual work with the students. Novelty: This study focused on the autistic student teacher’s pedagogical competence in the English Language Teaching (ELT) practicum based on eight teaching skills. No study investigates the pedagogical competence of autistic student teacher in ELT, mostly the previous researches investigated the pedagogical competence of the student teacher with a normal condition.
FEATURES OF THERAPY FOR ADENOIDITIS IN CHILDREN WITH RESPIRATORY ALLERGOSIS
Authors: Карпищенко С.А. , Роднева Ю.А. 
Published: June 2024

Cочетание гипертрофии аденоидов, риноаденоидита с другими заболеваниями верхних и нижних дыхательных путей, корреляция выраженности симптомов c иммунологическим и аллергологическим статусом ребенка, их взаимовлияние на степень проявлений симптомов являются актуальной проблемой. Поиск комбинированных методов лечения и контроль над полипрагмазией остаются ведущей задачей многих специалистов. В статье рассматриваются особенности течения, диагностики и лечения риноаденоидита при доказанном аллергозе. На основании анализа схожих клинических случаев показаны зависимость течения и успешность лечения данных патологий с применением антисептических и биорегулирующих средств.
The combination of adenoid hypertrophy, rhinoadenoiditis with other diseases of the upper and lower respiratory tract, the correlation of the severity of symptoms with the immunological and allergic status of the child, their mutual influence on the degree of manifestation of symptoms is an urgent problem. The search for combined treatment methods and control of polypharmacy remains the leading task of many specialists. In our article we consider the features of the course, diagnosis and treatment of rhinoadenoiditis with proven allergosis. Based on the analysis of similar clinical cases, we show the dependence of the course and success of treatment of these pathologies with the use of antiseptic and bioregulatory agents.
Employee Satisfaction in Small Scale Enterprises in Bangalore
Authors: Dr. S. Jayalakshmi Priya  
Published: June 2024

Employee satisfaction today is the most important thing which has to be taken care of by the management. In small scale enterprises it is often not given the importance as chasing after orders and carrying out production activities with greater significance. So what is the role played by the proprietor/manager to keep his enterprises in the optimal production stage and his employees satisfied? The research gap here refers to the desired targets not being met and the deadlines are not kept in any organization. Because of this problem the managers opt for a optimal production goal with sufficient production accruing satisfactory profits so that the employees are assured of their salaries on time and payment for overtime. This is so because the aspiration level of set target of production may be higher than the actual level acquired. The aspirational level of production targeted may be higher but if the actual level of production maybe lesser then the employee is dissatisfied due to less wages and because of fall in profits. So Simon’s Behavioral model of Satisficing tells us about the satisfaction and sufficing meaning a sufficient level of profits have to be earned to keep the employees at a satisfied level. The findings showed that higher salaries and payment for overtime was what brought about employee satisfaction. The sample size taken was 150. Electrical machining & fabricating industries was selected for study. The study centered around the primary data. The sampled respondents from Bangalore and Kolar small enterprises showed preference for welfare facilities such as transportation and canteen facilities.
Financial literacy of the population as a guarantee of economic security of the Russian banking sector
Authors: Гюнтер И.Н. , Тоноян А.А. 
Published: June 2024

В статье анализируется разница между методологиями исследований финансовой грамотности USAID и ОЭСР OECD / INFE. Определена разница между финансовой осведомленностью и грамотностью, исследована суть данных категорий. Подтверждено, что финансовая грамотность населения напрямую влияет на экономическую безопасность банковского сектора. В развитых странах также существует проблема с уровнем финансовой грамотности населения. Определено, что в странах с низким уровнем жизни финансовая грамотность ниже, чем в странах с высоким уровнем жизни. Установлены составляющие финансовой грамотности и факторы, определяющие ее уровень. Предложена концепция развития финансового образования для обеспечения безопасности банковского сектора. Рассмотрена финансовая грамотность и осведомленность как базис, а экономическая безопасность как надстройка, дающая четкое представление о роли финансовой грамотности в функционировании банковского сектора и обеспечении его безопасности.
The article explores the difference between the USAID and OECD OECD/INFE financial literacy research methodologies. The difference between financial awareness and literacy is determined, the essence of these categories is investigated. It is confirmed that the financial literacy of the population directly affects the economic security of the banking sector. In developed countries, there is also a problem with the level of financial literacy of the population. It is determined that in countries with a low standard of living, financial literacy is lower than in countries with a high standard of living. The components of financial literacy and the factors determining its level are established. The concept of the development of financial education to ensure the security of the banking sector is proposed. Financial literacy and awareness are considered as a basis, and economic security as a superstructure, which gave a clear idea of the role of financial literacy in the functioning of the banking sector and ensuring its security financial literacy, economic security, population, banking sector.
Rating diagnostics of regional development features the Central Federal District
Authors: Растопчина Ю.Л. , Титова И.Н. 
Published: June 2024

В статье рассматривается рейтинговая диагностика социально-экономического развития регионов по сгруппированным подмножествам показателей на основе данных Федеральной службы государственной статистики, что позволяет проводить сравнительный анализ субъектов России и выявлять их позиции в структуре регионов. Проведен аналитический обзор результатов рейтинговых агенств, которые отличаются набором индикаторов и подходами оценки. На основе представленных в исследовании рейтингов регионов определены лидеры и аутсайдеры по различным направлениям социально-экономического развития.
The article discusses the rating diagnostics of the socio-economic development of regions according to grouped subsets of indicators based on data from the Federal State Statistics Service, which allows for a comparative analysis of the constituent entities of the Russian Federation and identifying their positions in the structure of the regions. An analytical review of the results of rating agencies, which differ in the set of indicators and assessment approaches, was carried out. Based on the ratings of the Central Federal District regions presented in the study, leaders and outsiders in various areas of socio-economic development were identified.
FEATURES OF THE SIXTH TECHNOLOGICAL STRUCTURE IN THE CONTEXT OF TRANSFORMATION OF ECONOMIC POLICY AND GOVERNMENT REGULATION
Authors: Ширганов А.В. 
Published: June 2024

В статье анализируются изменения в существующей экономической системе при ее переходе к шестому технологическому укладу в контексте преобразования экономической политики и государственного регулирования. Доказано, что: 1) регулирование сферы технологического производства имеет сетевой характер; 2) непременной необходимостью выступает усиление международной кооперации; 3) глобальный характер влияния технологий на мировую экономическую систему приводит к обострению международной конкуренции между национальными экономиками; 4) государства начинают функционировать в условиях тотальности не контролируемых ими различных структур глобального уровня. Также автором проанализировано место современной России в шестом технологическом укладе.
The article analyzes changes in the existing economic system during its transition to the sixth technological order in the context of the transformation of economic policy and government regulation. It has been proven that: 1) regulation of the sphere of technological production is of a network nature; 2) strengthening international cooperation is an absolute necessity; 3) the global nature of the influence of technology on the world economic system leads to increased international competition between national economies; 4) states begin to function «in conditions of totality not controlled by them» of various structures at the global level. The place of modern Russia in the sixth technological order is also analyzed.
Why Is Gender Diversity Important for Corporate Boards?
Authors: Mustapha Fatima Gana , Adamu Idris Adamu , Abudllahi Zaharaddin 
Published: June 2024

The diversity of backgrounds, perspectives, abilities, and resources on boards improves a company’s performance. In recent times, board gender diversity has attracted the attention of policymakers, regulators, and academics. This study explored the influence of board gender diversity on corporate performance. The sample of the study consists of 15 consumer goods companies on the Nigerian Exchange Group from 2012 to 2021. The study uses fixed effects regression to estimate the model. The evidence indicates that gender diversity “proxied” by female directors on the boards has a positive outcome and significantly affects corporate performance. Hence, consumer goods companies may perform better as a whole if they have more female directors on their boards. The findings are consistent with prior studies and with resource dependency theory. The study suggests that companies with zero female directors should hire them while those with a single female director should consider adding more since corporate performance will be improved as a result.

Received: 14 January 2024 | Revised: 6 May 2024 | Accepted: 16 May 2024

Conflicts of Interest
The authors declare that they have no conflicts of interest to this work.

Data Availability Statement
The data that support this work are available upon reasonable request to the corresponding author.

Author Contribution Statement
Fatima Gana Mustapha: Conceptualization, Formal analysis, Investigation. Idris Adamu Adamu: Software, Resources, Data curation, Writing – original draft, Writing – review & editing, Visualization, Funding acquisition. Zaharaddin Abudllahi: Methodology, Validation, Supervision, Project administration, Funding acquisition.
Are Entrepreneurs Probabilists or Possibilists? Observing Opportunity as Possibilities, Probabilistically
Authors: Leong David 
Published: June 2024

This paper explores uncertainty, possibility, and entrepreneurial inclination in entrepreneurship. It presents a novel probabilistic lens to comprehend uncertainty and its impact on entrepreneurial theory and practice, highlighted through analyzing decision-making behavior via the Monty Hall problem. The deterministic perspective is called into question when entrepreneurship is depicted as an agent whose outcomes are indeterminate and probabilistically predetermined. Entrepreneurs effectively handle risk and uncertainty, venturing into uncharted territories to attain possible benefits. The research distinguishes between probabilists, who base their decision-making on likelihoods, and possibilists, who investigate the attainable through imaginative potential. This possibilist approach incorporates concepts of contingency and potential, recognizing both the potential outcomes and the associated dangers, making a valuable contribution to practical application. Theoretically, this paper contributes to the entrepreneurship literature by offering the Many-Doors model as a tool for understanding the complex interplay between an individual’s inclination toward probability or possibility and their entrepreneurial decisions. This conceptual model functions as a link integrating elements of risk, uncertainty, and strategic choice, thereby broadening the theoretical frameworks used to analyze entrepreneurial behavior, potentially resulting in a more holistic understanding of entrepreneurial dynamics.

Received: 31 January 2024 | Revised: 25 April 2024 | Accepted: 14 May 2024

Conflicts of Interest
The author declares that he has no conflicts of interest to this work.

Data Availability Statement
No data was used in this research as this is a conceptual paper.

Author Contribution Statement
David Leong: Conceptualization, Methodology, Software, Validation, Formal analysis, Investigation, Resources, Data curation, Writing – original draft, Writing – review & editing, Visualization, Supervision, Project administration, Funding acquisition.
La propuesta de paz más viable del FMLN
Authors: Acevedo Carlos 
Published: June 2024

Nuestro propósito en el presente artículo consiste en examinar someramente en qué consiste la novedad de dicha propuesta y hasta qué punto puede ser viable. Nos preguntamos qué es lo que en la última propuesta del FMLN ha generado una convocatoria tan exitosa. Asimismo analizamos las diversas reacciones ante ella por parte de los partidos políticos, el presidente, la Fuerza Armada, Estados Unidos, y las organizaciones laborales.
La "Propuesta del FMLN para convertir las elecciones en una contribución a la paz" constituye sin duda alguna la oferta de paz más viable que la insurgencia salvadoreña ha presentado en todo lo que va de la guerra. También parece constituir la oferta más novedosa entre todas las propuestas políticas presentadas anteriormente por el FMLN. Nuestro propósito en el presente artículo consiste en examinar someramente en qué consiste la novedad de dicha propuesta y hasta qué punto puede ser viable.
ECA Estudios Centroamericanos, Vol. 44, No. 483-484, 1989: 53-77.
Duration of Double Balloon Catheter for Patients with Prior Cesarean: A Before and After Study
Authors: Tang Rachel , Baugh Kyle , Bode Leah , Daggy Joanne , Mosesso Kelly , Guise David , Teal Evgenia , Christman Megan , Tuskan Britney , Haas David 
Published: June 2024

Objective: To evaluate, in patients with a prior history of cesarean delivery undergoing cervical ripening with a double balloon catheter, whether removal of device after six hours versus twelve hours would result in shorter time to delivery. Methods: A before-and-after study was performed after a practice change occurred November 2020, at which time the standard duration of double cervical balloon catheter placement during induction was changed from twelve hours to six hours. Data was collected via retrospective electronic chart review. Inclusion criteria included singleton pregnancy, history of prior cesarean delivery, fetus in cephalic presentation upon admission, and cervical ripening accomplished with a double balloon catheter. Patients with multiple gestation pregnancy, those with more than one balloon catheter placed during labor, and those being induced for fetal demise were excluded from this study. Primary outcome was time from balloon placement to delivery. Secondary outcomes included rates of cesarean delivery and rates of maternal intraamniotic infection. Uterine rupture was a safety outcome. Kaplan-Meier curves compared median times to delivery between the groups. A Cox proportional-hazards model was used to adjust for time of balloon placement, number of previous vaginal deliveries, and co-medications used. Results: From November 2018 to November 2022, 210 patients with a prior history of cesarean delivery received a double balloon catheter for cervical ripening during their trial of labor. After chart review, 189 patients were found to be eligible. The patients were separated into pre- and post-policy change groups (n=91 and 98, respectively). The median time to vaginal delivery for the pre-group was 28 hours (95% CI: 26, 35) and 25 hours (95% CI: 23, 29) for those in the post-group (p-value 0.052). After adjusting for dilation at time of balloon placement, number of previous vaginal deliveries, and co-medication, the estimated hazard ratio for successful vaginal delivery post-policy change was 1.89 (95% CI: 1.27, 2.81). There were no differences in rates of secondary outcomes. Conclusion: In patients with prior cesarean delivery undergoing mechanical cervical ripening with a double balloon catheter, planned removal at 6 hours compared to 12 hours may result in shorter time to delivery without increasing rates of cesarean and intraamniotic infection. Shortened time to delivery has been known to reduce maternal and perinatal morbidity, such as infection, hemorrhage, and cesarean delivery as well as conserve hospital resources and improve patient satisfaction. Decreasing duration of balloon placement in this population should be considered.