bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Hip Antero-Superior Labral Tear with Avulsion of Rectus Femoris (Haltar) Lesion: Does the Slap Equivalent in the Hip Exist?
Authors: Hosalkar Harish S. , Pennock Andrew T. , Zaps Daniela , Schmitz Matthew R. , Bomar James D. , Bittersohl Bernd 
Published: August 2012

Background The purpose of this report is to describe a new lesion, the “Hip Antero-superior Labral Tear with Avulsion of Rectus femoris (HALTAR)”. This injury may be seen in both adolescent and skeletally mature athletes and shares several characteristics with the “Superior Labral tear from Anterior to Posterior (SLAP)” lesion in the shoulder. Methods We present a case example, as well as a detailed anatomic description of the pathological condition. Results As the rectus femoris crosses two joints it is exposed to substantial forces during muscle contraction. Considering the peri-articular origin of the reflected head at the superior aspect of the acetabular rim, a powerful eccentric contraction of the rectus femoris muscle or traction related to sudden knee flexion may cause an avulsion injury of the rectus femoris as well as a concomitant labral tear. Conclusions A strain injury of the rectus femoris muscle, which is common in young athletic patients, may cause a concomitant tear of the acetabular labrum. Therefore, we recommend further diagnostic work-up in cases with prolonged hip pain and impaired hip function following an AIIS injury in order to identify any associated peri- and intra-articular damage. In our experience these patients seldom need aggressive surgical management.
BOSQUES SECUNDARIOS DESARROLLADOS EN TIERRAS AGRÍCOLAS ABANDONADAS EN LA REGIÓN DEL PACÍFICO DE NICARAGUA. PROCEDIMIENTO PARA LA RESTAURACIÓN DE ECOSISTEMAS FORESTALES DEGRADADOS
Authors: Castro-Marín Guillermo , Gonzalez-Rivas Benigno 
Published: August 2012

En el presente estudio se determinó la composición de especie, diversidad y estructura de la población arbórea de tres bosques secundarios con edades de 4, 9 y 14 años, derivados de tierras agrícolas abandonadas en la comarca La Chipopa-Rio Medina, Nandaime. Todos los individuos de igual altura, o con alturas superiores a 0.30 m de altura fueron identificados y medidos en 70 parcelas de 100 m2 en cada uno de los bosques bajo estudio. Un total de 12, 29 y 22 familias and subfamilias representadas por 17, 48 and 44 especies fueron registradas en los bosques de 4, 9 and 14 años, respectivamente. A través de la cronosecuencia de los bosques secundarios se registró un cambio en las especies dominantes, Lonchocarpus acuminatus registro el índice de mayor importancia en la estado sucesional de 4 años, Myrospermun frutescens y Guazuma ulmifolia tuvieron el más alto índice de valor de importancia en el estado de 9 años and Caesaeria corymbosa y Muntingia calabura, en el bosque de 14 años. La densidad y el área basal incrementaron al aumentar la edad de los bosques secundarios de 4 a 14 años. La diversidad de especie fue mayor en el bosque de 9 años seguido de 14 y 4- años. Se concluye que la recuperación de la vegetación arbórea sobre campos agrícolas abandonados está marchando satisfactoriamente y es un procedimiento adecuado para la restauración forestal, sin embargo, medidas de protección y conservación deben de ser implementadas a fin de evitar perturbaciones naturales o antropogénicas que reviertan el proceso de sucesión. Se recomienda implementar medidas silviculturales como plantaciones de enriquecimiento que aceleren el proceso de recuperación y restauración de las áreas bajo estudio. DOI: http://dx.doi.org/10.5377/calera.v11i16.748 La Calera Vol. 11, No 16 p. 12-23/junio 2011
Newborn Screening for High-Risk Congenital Heart Disease by Dried Blood Spot Biomarker Analysis
Authors: Clausen Henning , Friberg Elin , Lannering Katarina , Koivu Aki , Sairanen Mikko , Mellander Mats , Liuba Petru 
Published: June 2024

ImportanceCongenital heart disease (CHD) is the most common human organ malformation, affecting approximately 1 of 125 newborns globally.ObjectivesAssessing the performance of 2 diagnostic tests using minimal amounts of dried blood spots (DBS) to identify high-risk CHD compared with controls in a Swedish cohort of neonates.Design, Setting, and ParticipantsThis diagnostic study took place in Sweden between 2019 and 2023 and enrolled full-term babies born between 2005 and 2023. All cases were identified through centralized pediatric cardiothoracic surgical services in Lund and Gothenburg, Sweden. Controls were followed up for 1 year to ensure no late presentations of high-risk CHD occurred. Cases were verified through surgical records and echocardiography.ExposureHigh-risk CHD, defined as cases requiring cardiac surgical management during infancy due to evolving signs of heart failure or types in which the postnatal circulation depends on patency of the arterial duct. Using 3-μL DBS samples, automated quantitative tests for NT-proBNP and interleukin 1 receptor-like 1 (IL-1 RL1; formerly known as soluble ST2) were compared against established CHD screening methods.Main Outcomes and MeasuresPerformance of DBS tests to detect high-risk CHD using receiver operating characteristic curves; Bland-Altman and Pearson correlation analyses to compare IL-1 RL1 DBS with plasma blood levels.ResultsA total of 313 newborns were included (mean [SD] gestational age, 39.4 [1.3] weeks; 181 [57.8%] male). Mean (SD) birthweight was 3495 (483) grams. Analyzed DBS samples included 217 CHD cases and 96 controls. Among the CHD cases, 188 participants (89.3%) were high-risk types, of which 73 (38.8%) were suspected prenatally. Of the 188 high-risk cases, 94 (50.0%) passed pulse oximetry screening and 36 (19.1%) were initially discharged after birth without diagnoses. Combining NT-proBNP and IL-1 RL1 tests performed well in comparison with existing screening methods and enabled additional identification of asymptomatic babies with receiver operating characteristic area under the curve 0.95 (95% CI, 0.93-0.98).Conclusions and relevanceIn this diagnostic study, NT-proBNP and IL-1 RL1 DBS assays identified high-risk CHD in a timely manner, including in asymptomatic newborns, and improved overall screening performance in this cohort from Sweden. Prospective evaluation of this novel approach is warranted.
Cardiovascular Risk Factors in Childhood and Adulthood and Cardiovascular Disease in Middle Age
Authors: Kartiosuo Noora , Raitakari Olli T. , Juonala Markus , Viikari Jorma S. A. , Sinaiko Alan R. , Venn Alison J. , Jacobs David R. , Urbina Elaine M. , Woo Jessica G. , Steinberger Julia , Bazzano Lydia A. , Daniels Stephen R. , Magnussen Costan G. , Rahimi Kazem , Dwyer Terence 
Published: June 2024

ImportanceRecent evidence suggests that childhood levels of serum lipids, blood pressure, body mass index (BMI), and smoking contribute to adult risk of cardiovascular disease (CVD). Evidence is lacking on whether this is independent of adult risk levels.ObjectiveTo quantify direct and indirect effects of childhood risk factors on adult CVD via adulthood risk factors using mediation analysis, and to quantify their relative importance during different life-course stages using a life-course approach.Design, Setting, and ParticipantsThis prospective cohort study followed participants from the US, Finland, and Australia from childhood (1970s-1990s) until 2019, with data on CVD risk factors in childhood and adulthood. Longitudinal childhood and adulthood risk factors were summarized to describe BMI, lipids, and blood pressure cumulatively. Childhood and adulthood smoking were assessed with questionnaires. Data analysis was performed May 2022 to August 2023.Main Outcomes and MeasuresThe primary outcomes were fatal and nonfatal cardiovascular events in adulthood. Mediation analysis was used to estimate the direct and indirect effects of the childhood risk factors with CVD events, reported as incidence rate ratios (RRs) and 95% CIs.ResultsA total of 10 634 participants (4506 male participants [42.4%]; mean [SD] age at childhood visit, 13.3 [3.0] years; mean [SD] age at adulthood visit, 32.3 [6.0] years) were included in the cohort. The mean (SD) age at CVD event or censoring was 49.2 (7.0) years. The median (IQR) follow-up time was 23.6 (18.7-30.2) years. Childhood risk factors, (low-density lipoprotein cholesterol [LDL-C], total cholesterol [TC], triglycerides, systolic blood pressure [SBP], smoking, BMI, and a combined score of these) were associated with CVD. BMI (direct effect for incidence RR per 1 SD unit, 1.18; 95% CI, 1.05-1.34) and LDL-C (direct effect incidence RR, 1.16; 95% CI, 1.01-1.34) in particular were found to play an important role via direct pathways, whereas the indirect effects were larger for TC, triglycerides, SBP, and the combined score. Childhood smoking only affected CVD via adulthood smoking. Life-course models confirmed that for the risk of CVD, childhood BMI plays nearly as important role as adulthood BMI, whereas for the other risk factors and the combined score, adulthood was the more important period.Conclusions and RelevanceIn this cohort study of 10 634 participants, childhood risk factors were found to be associated both directly and indirectly to adult CVD, with the largest direct effect seen for BMI and LDL-C. These findings suggest that intervention for childhood risk factors, in particular BMI, is warranted to reduce incidence of adult CVD as it cannot be fully mitigated by risk factor management in adulthood.
Discovering Facet‐Dependent Formation Kinetics of Key Intermediates in Electrochemical Ammonia Oxidation by a Electrochemiluminescence Active Probe
Authors: Sun Dina , Zhang Jiaqi , Wang Heng , Song Yanxia , Du Jing , Meng Genping , Sun Shihao , Deng Weihua , Wang Zhiyi , Wang Baodui 
Published: June 2024

AbstractFacile evaluation of formation kinetics of key intermediate is crucial for a comprehensive understanding of electrochemical ammonia oxidation reaction (AOR) mechanisms and the design of efficient electrocatalysts. Currently, elucidating the formation kinetics of key intermediate associated with rate‐determining step is still challenging. Herein, 4‐phtalamide‐N‐(4′‐methylcoumarin) naphthalimide (CF) is developed as a molecular probe to detect N2H4 intermediate during AOR via electrochemiluminescence (ECL) and further investigated the formation kinetics of N2H4 on Pt catalysts with different crystal planes. CF probe can selectively react with N2H4 to release ECL substance luminol. Thus, N2H4 intermediate as a key intermediate can be sensitively and selectively detected by ECL during AOR. For the first time, Pt(100) facet is discovered to exhibit faster N2H4 formation kinetics than Pt(111) facet, which is further confirmed by Density functional theory calculation and the finite element simulation. The AOR mechanism under the framework of Gerischer and Mauerer is further validated by examining N2H4 formation kinetics during the dimerization process (NH2 coupling). The developed ECL active probe and the discovered facet‐dependent formation kinetics of key intermediates provide a promising new tool and strategy for the understanding of electrochemical AOR mechanisms and the design of efficient electrocatalysts.
A Fast‐Charging and Ultra‐Stable Sodium‐Ion Battery Anode Enabled by N‐Doped Bi/BiOCl in a Carbon Framework
Authors: Wei Sheng‐Li , Yang Yan‐Ling , Chen Jin‐Geng , Shi Xiao‐Lei , Sun Yu , Li Peng , Tian Xue‐Feng , Chen Hua‐Jun , Luo Zhao , Chen Zhi‐Gang 
Published: June 2024

AbstractOwing to the abundant reserves and low cost, sodium‐ion batteries (SIBs) have garnered unprecedented attention. However, their widespread adoption is hindered by the scarcity of alternative anodes with fast‐charging capability and high stability. To overcome this challenge, a fast‐charging SIB anode, N‐doped Bi/BiOCl embedded in a carbon framework (Bi/BiOCl@NC) with a fast Na+ transport channel and ultra‐high structural stability, is developed. During cycling in ether electrolyte, Bi/BiOCl@NC undergoes a remarkable transformation into a 3D porous skeleton, which significantly reduces the Na+ transport pathway and accommodates volume changes. By employing density functional theory calculations to simulate the storage behavior of Na+ in the structure, Bi/BiOCl@NC is theoretically characterized to have a low Na+ transport barrier (0.056 eV) and outstanding electronic conductivity. Such unique characteristics induce Bi/BiOCl@NC anode to have an ultra‐high Na+ storage capacity of 410 mAh·g−1 at 20 A·g−1 and exhibit outstanding cycling stability with over 2300 cycles at 10 A·g−1. This study provides a rational scenario for the fast‐charging anode design and will enlighten more advanced research to promote the exploitation of SIBs.
Reanalysis of RNA sequencing data ends diagnostic odyssey and expands the phenotypic spectrum of congenital titinopathy
Authors: McNamee Lucy , Schoch Kelly , Huang Alden , Lee Hane , Wang Lee‐kai , Smith Edward C. , Lark Robert K. , Buckley Anne F. , Jobanputra Vaidehi , Nelson Stanley F. , Shashi Vandana ,   Undiagnosed Diseases Network
Published: June 2024

AbstractAlthough next‐generation sequencing has enabled diagnoses for many patients with Mendelian disorders, the majority remain undiagnosed. Here, we present a sibling pair who were clinically diagnosed with Escobar syndrome, however targeted gene testing was negative. Exome sequencing (ES), and later genome sequencing (GS), revealed compound heterozygous TTN variants in both siblings, a maternally inherited frameshift variant [(NM_133378.4):c.36812del; p.(Asp12271Valfs*10)], and a paternally inherited missense variant [(NM_133378.4):c.12322G > A; p.(Asp4108Asn)]. This result was considered nondiagnostic due to poor clinical fit and limited pathogenicity evidence for the missense variant of uncertain significance (VUS). Following initial nondiagnostic RNA sequencing (RNAseq) on muscle and further pursuit of other variants detected on the ES/GS, a reanalysis of noncanonical splice sites in the muscle transcriptome identified an out‐of‐frame exon retraction in TTN, near the known VUS. Interim literature included reports of patients with similar TTN variants who had phenotypic concordance with the siblings, and a diagnosis of a congenital titinopathy was given 4 years after the TTN variants had been initially reported. This report highlights the value of reanalysis of RNAseq with a different approach, expands the phenotypic spectrum of congenital titinopathy and also illustrates how a perceived phenotypic mismatch, and failure to consider known variants, can result in a prolongation of the diagnostic journey.
Polyelectrolyte‐Mediated Modulation of Spatial Internal Stresses of Hydrogels for Complex 3D Actuators
Authors: Duan Jinghua , Fan Wenxin , Xu Zihan , Cui Lu , Wang Ziyou , Nie Zhihong , Sui Kunyan 
Published: June 2024

AbstractHydrogel actuators with complex 3D initial shapes show numerous important applications, but it remains challenging to fabricate such actuators. This article describes a polyelectrolyte‐based strategy for modulating small‐scale internal stresses within hydrogels to construct complex actuators with tailored 3D initial shapes. Introducing polyelectrolytes into precursor solutions significantly enhances the volume shrinkage of hydrogel networks during polymerization, allowing us to modulate internal stresses. Photopolymerization of these polyelectrolyte‐containing solutions through a mask produces mechanically strong hydrogel sheets with large patterned internal stresses. Consequently, these hydrogel sheets attain complex 3D initial shapes at equilibrium, in contrast to the planar initial configuration of 2D actuators. We demonstrate that these 3D actuators can reversibly transform into other 3D shapes (i.e., 3D‐to‐3D shape transformations) in response to external stimuli. Additionally, we develop a predictive model based on the Flory‐Rehner theory to analyze the polyelectrolyte‐mediated shrinking behaviors of hydrogel networks during polymerization, allowing precise modulation of shrinkage and internal stress. This polyelectrolyte‐boosted shrinking mechanism paves a route to the fabrication of high‐performance 3D hydrogel actuators.
Comparison of Gout Flares With the Initiation of Treat‐to‐Target Allopurinol and Febuxostat: A Post‐Hoc Analysis of a Randomized Multicenter Trial
Authors: Barry Austin , Helget Lindsay N. , Androsenko Maria , Wu Hongsheng , Kramer Bridget , Newcomb Jeff A. , Brophy Mary T. , Davis‐Karim Anne , England Bryant R. , Ferguson Ryan , Pillinger Michael H. , Neogi Tuhina , Palevsky Paul M. , Merriman Tony R. , O'Dell James R. , Mikuls Ted R. 
Published: June 2024

ObjectiveInitiating urate‐lowering therapy (ULT) in gout can precipitate arthritis flares. There have been limited comparisons of flare risk during the initiation and escalation of allopurinol and febuxostat, administered as a treat‐to‐target strategy with optimal anti‐inflammatory prophylaxis.MethodsThis was a post‐hoc analysis of a 72‐week randomized, double‐blind, placebo‐controlled, noninferiority trial comparing the efficacy of allopurinol and febuxostat. For this analysis, the occurrence of flares was examined during weeks 0 to 24 when ULT was initiated and titrated to a serum urate (sUA) goal of less than 6 mg/dl (<5 mg/dl if tophi). Flares were assessed at regular intervals through structured participant interviews. Predictors of flare, including treatment assignment, were examined using multivariable Cox proportional hazards regression.ResultsStudy participants (n = 940) were predominantly male (98.4%) and had a mean age of 62.1 years with approximately equal proportions receiving allopurinol or febuxostat. Mean baseline sUA was 8.5 mg/dl and all participants received anti‐inflammatory prophylaxis (90% colchicine). In a multivariable model, there were no significant associations of ULT treatment (hazard ratio [HR] 1.17; febuxostat vs allopurinol), ULT‐dose escalation (HR 1.18 vs no escalation), prophylaxis type, or individual comorbidity with flare and no evidence of ULT‐dose escalation interaction. Factors independently associated with flare risk during ULT initiation/escalation included younger age, higher baseline sUA, and absence of tophi.ConclusionThese results demonstrate that gout flare risk during the initiation and titration of allopurinol is similar to febuxostat when these agents are administered according to a treat‐to‐target strategy using gradual ULT‐dose titration and best practice gout flare prophylaxis.
Proper hepatic artery transection followed by blunt abdominal trauma: A case report and review of literature
Authors: Naseri Reyhaneh , Alishavandi Fatemeh , Rajabian Mohammad Sadegh , Fard Hossein Abdolrahimzadeh 
Published: June 2024

Key Clinical MessageAbdominal vascular injuries, especially in the celiac trunk, are uncommon in blunt trauma, yet their life‐threatening nature necessitates rapid surgical interventions to control possible massive bleedings. Damage control surgery principles may aid management. It is crucial to thoroughly assess all trauma patients, even in instances of initial normal physical examinations.
Endodontic management of taurodontic teeth: A case series
Authors: Chamani Ali , Azizi Vahid , Karimpour Sahar 
Published: June 2024

Key Clinical MessageThis paper illustrated successful endodontic non‐surgical (re)treatments of molars and premolar with different taurodontic classifications and accompanied anomalies like C‐shape and extra root canals in otherwise healthy patients. Magnification with illumination besides active irrigation with NaOCl were the most helpful items in managing these cases.
Red Fluorescent Aminoferrocene (Pro)Drugs for in Cellulo and in Vivo Imaging
Authors: Chernii Svitlana , Selin Roman , Bila Galyna , Bilyy Rostyslav , Körber Marlies , Mokhir Andriy 
Published: June 2024

AbstractRed fluorescent dyes are usually charged, lipophilic molecules with relatively high molecular weight, which tend to localize in specific intracellular locations, e. g., a cyanine dye Cy5 is biased towards mitochondria. They are often used as markers of biomolecules including nucleic acids and proteins. Since the molecular weight of the dyes is much smaller than that of the biomolecules, the labelling has a negligible effect on the properties of the biomolecules. In contrast, conjugation of the dyes to low molecular weight (pro)drugs can dramatically alter their properties. For example, conjugates of Cy5 with lysosome‐targeting aminoferrocenes accumulate in mitochondria and exhibit no intracellular effects characteristic for the parent (pro)drugs. Herein we tested several neutral and negatively charged dyes for labelling lysosome‐targeting aminoferrocenes 7 and 8 as well as a non‐targeted control 3. We found that a BODIPY derivative BDP‐TR exhibits the desired unbiased properties: the conjugation does not disturb the intracellular localization of the (pro)drugs, their mode of action, and cancer cell specificity. We used the conjugates to clarify the mechanism of action of the aminoferrocenes. In particular, we identified new intermediates, explained why lysosome‐targeting aminoferrocenes are more potent than their non‐targeted counterparts, and evaluated their distribution in vivo.
Researches for higher electrical conductivity copper‐based materials
Authors: Zhang Wen‐Jing , Huang Lue , Mi Xu‐Jun , Xie Hao‐Feng , Feng Xue , Ahn Jee Hyuk 
Published: June 2024

AbstractCopper and copper‐based materials are widely used in power electronics, automobiles, mechanical manufacturing and high‐tech manufacturing fields such as aerospace, telecommunications and integrated circuits owing to their comprehensive advantages in mechanical, electrical conductivity and processing properties. With the rapid development of technology, many emerging technical fields have introduced more challenging requirements for the electrical conductivity of copper. This article reviews the research status of high‐conductivity copper‐based materials and introduces three methods to improve electrical conductivity, including purification, alloying and addition of nanocarbon materials. We summarise the advantages, disadvantages and future development trends of methods for improving copper conductivity. The key to producing high‐conductivity copper‐based materials is development of low‐cost, continuous and stable processes.