bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does prior short-segment surgery for adult scoliosis impact perioperative complication rates and clinical outcome among patients undergoing scoliosis correction?
Authors: Kasliwal Manish K. , Smith Justin S. , Shaffrey Christopher I. , Carreon Leah Y. , Glassman Steven D. , Schwab Frank , Lafage Virginie , Fu Kai-Ming G. , Bridwell Keith H. 
Published: June 2012

Object
In many adults with scoliosis, symptoms can be principally referable to focal pathology and can be addressed with short-segment procedures, such as decompression with or without fusion. A number of patients subsequently require more extensive scoliosis correction. However, there is a paucity of data on the impact of prior short-segment surgeries on the outcome of subsequent major scoliosis correction, which could be useful in preoperative counseling and surgical decision making. The authors' objective was to assess whether prior focal decompression or short-segment fusion of a limited portion of a larger spinal deformity impacts surgical parameters and clinical outcomes in patients who subsequently require more extensive scoliosis correction surgery.

Methods
The authors conducted a retrospective cohort analysis with propensity scoring, based on a prospective multicenter deformity database. Study inclusion criteria included a patient age ≥ 21 years, a primary diagnosis of untreated adult idiopathic or degenerative scoliosis with a Cobb angle ≥ 20°, and available clinical outcome measures at a minimum of 2 years after scoliosis surgery. Patients with prior short-segment surgery (< 5 levels) were propensity matched to patients with no prior surgery based on patient age, Oswestry Disability Index (ODI), Cobb angle, and sagittal vertical axis.

Results
Thirty matched pairs were identified. Among those patients who had undergone previous spine surgery, 30% received instrumentation, 40% underwent arthrodesis, and the mean number of operated levels was 2.4 ± 0.9 (mean ± SD). As compared with patients with no history of spine surgery, those who did have a history of prior spine surgery trended toward greater blood loss and an increased number of instrumented levels and did not differ significantly in terms of complication rates, duration of surgery, or clinical outcome based on the ODI, Scoliosis Research Society-22r, or 12-Item Short Form Health Survey Physical Component Score (p > 0.05).

Conclusions
Patients with adult scoliosis and a history of short-segment spine surgery who later undergo more extensive scoliosis correction do not appear to have significantly different complication rates or clinical improvements as compared with patients who have not had prior short-segment surgical procedures. These findings should serve as a basis for future prospective study.
In vitro Propagation of Stemona tuberosa Lour. - A Rare Medicinal Plant through High Frequency Shoot Multiplication using Nodal Explants
Authors: Biswas Animesh , Bari M. A. , Roy Mohashweta , Bhadra S. K. 
Published: June 2012

Nodal segments of Stemona tuberosa Lour. were found to proliferated without any differentiation on to MS supplemented with 3.0 mg/l BAP and 0.5 mg/l NAA under continuous dark condition. After 20 days of inoculation under dark condition the cultures were transferred to a daily cycle of 16/8 hrs light/dark photoperiod and there the proliferated nodal segments underwent direct organogenesis producing huge number of shoot buds (25.87/culture). The shoot buds underwent rapid elongation on a range of BAP (0.1 - 1.5 mg/l) and IBA (0.1 - 1.0 mg/l) supplemented MS. Rooting of elongated shoot buds was successfully achieved (90%) in half strength MS with 1.0 mg/l NAA. The plantlets were finally established in outside environment through a successive phase of acclima-tization. Key words: Nodal explant, Stemona tuberose, Rare medicinal plant, Direct organogenesis D. O. I. 10.3329/ptcb.v21i2.10238 Plant Tissue Cult. & Biotech. 21(2): 151-159, 2011 (December)
High Frequency Regeneration of Plantlets from Immature Male Floral Explants of Musa paradisica cv. Puttabale - AB Genome
Authors: Kumar K. Girish , Krishna V. , Venkatesh Venkatesh , Pradeep K. 
Published: June 2012

High frequency in vitro regeneration for mass multiplication from immature male floral explants of Musa paradisica cv. Puttabale on MS supplemented with adenine sulfate (160 mg/l), tyrosine (100 mg/l), sucrose (40 g/l) and gelled with 0.8 g/l agar was attempted. For callus induction the combinations of 2, 4-D and BAP were tested at 1.0 - 10.0 mg/l and 0.5 - 5.0 mg/l, respectively. For shoot bud formation combinations of BAP and TDZ were also tested at 1.0 - 5.0 mg/l and 0.1 - 0.5 mg/l, respectively. Luxuriant proliferation and high frequency induction (97.0%) of callus was noticed from the accessory floral part of the explant at 7.0 mg/l 2, 4-D and 1.0 mg/l BAP, later it preceded towards the gynoecium. Interaction of BAP (2.0  5.0 mg/l) and TDZ (0.2 - 0.5 mg/l) would provoke high frequency shoot bud differentiation from the floral calli and a mean of 29.40 ± 6.10 shootlets per callus was obtained at 4 mg/l BAP and 0.4 mg/l TDZ. Rooting of the microshoots was achieved on MS containing 0.6 mg/l NAA and 0.2% activated charcoal. Key words: Musa pardisica, Puttabale, Regeneration, Male floral explants. D. O. I. 10.3329/ptcb.v21i2.10243 Plant Tissue Cult. & Biotech. 21(2): 199-205, 2011 (December)
La Bible du roi : le Deutéronome et Josué dans les Bibles moralisées et les vitraux de la Sainte-Chapelle
Authors: Lini Gabriella 
Published: June 2012

Sulla base di un serrato confronto iconografico si è potuto accertare, in questo studio, che le Bibbie moralizzate del primo terzo del tredicesimo secolo hanno esercitato un'influenza sull'illustrazione della vetrata della Sainte-Chapelle di Parigi dedicata al Deuteronomio e a Giosuè (finestra L). Ben due terzi dei pannelli istoriati mostrano delle affinità, più o meno manifeste, con i rispettivi cicli dei manoscritti. Il confronto permette inoltre di riconoscere degli episodi appartenenti all'uno o all'altro ciclio biblico su alcuni quadrilobi scartati dalle vetrate G, F e A durante i lavori di restauro del diciannovesimo secolo, e conservati in parte solo su disegno.
L'esame dettagliato della totalità dei vetri originali permette, in diversi casi, di convalidare o di precisare la loro identificazione attuale, in altri, esso impone una nuova lettura della scena rappresentata. Ne consegue una fondamentale revisione della disposizione dei pannelli. La ricerca evidenzia inoltre il messaggio politico trasmesso tramite il decoro figurato della vetrata. Nelle Bibbie moralizzate, conformemente al suo stato, Giosuè è rappresentato corne semplice conduttore del popolo d'Israele, alla Sainte-Chapelle invece, porta sistematicamente una corona, indossa abiti militari nelle azioni di guerra e un elegante mantello nelle altre occasioni. Traspare dunque da questo personaggio la figura di un re guerriero, di cui, tramite diverse digressioni dal testo biblico, sono evidenziati i poteri sacerdotali e la grande devozione. Si riconosce difatti, nella finestra L della Sainte-Chapelle, la figura ideale del sovrano crociato. Immagine, forse, che Luigi IX ha voluto lasciare di se stesso alla vigilia della partenza per la Terra santa.
Bone graft scintigraphy
Authors: Krohn T. , Ghassemi A. , Gerressen M. , Verburg F. A. , Mottaghy F. M. , Behrendt F. F. 
Published: June 2012

Summary
Aim: To evaluate a scintigraphic tool for intra - operative assessment of vascularized bone graft perfusion before and after transplantation. Patients, methods: This pilot study included three patients scheduled for surgical segmental mandibulectomy followed by reconstruction with a vascularized iliac bone graft. A continuous 99mTc-pertechnetate infusion was applied selectively arterial into the blood vessel supplying the respective graft before osteotomy as well as after transplantation. Perfusion was analysed by scintigrams acquired using the intraoperative camera systems declipseSPECT and Sentinella. Results were compared qualitatively. Results: Before harvesting the graft, intraoperative scintigraphy revealed a clearly delineated area of the iliac crest with a relatively homogenous pertechnetate distribution representing good perfusion. After osteotomy, transplantation to the mandibula and re-anastomosis of the nutrient vessels, scintigraphy in all patients showed a moderately inhomogenous distribution pattern of the pertechnetate indicating an adequate perfusion of the bone transplant through the arterial anastomosis. Conclusion: Intraoperative assessment of bone graft perfusion is possible with the imaging systems Sentinella as well as with declipse SPECT using a continuous intra-arterial infusion of 99mTc-pertechnetate.
End-stage Posttraumatic Osteoarthritis Treated With THA in Osteogenesis Imperfecta
Authors: Chaus George W. , Heare Travis 
Published: June 2012

Osteogenesis imperfecta is an incurable genetic disorder manifested with altered bone quality that predisposes patients to a multitude of fractures throughout their lives, including acetabular fractures. The management of acetabular fractures in patients with osteogenesis imperfecta remains a challenging clinical problem, with a paucity of literature supporting treatments and their outcomes. Limited reports in the literature validate the use of total hip arthroplasty (THA) in patients with osteogenesis imperfecta, and they describe the adult population only.
This article describes a case of delayed diagnosis of a transverse acetabular fracture and femoral head impaction fracture that led to posttraumatic end-stage hip osteoarthritis in a 16-year-old boy with osteogenesis imperfecta (Sillence Type I) that was sustained after minimal trauma. Clinical examination 3 months postinjury revealed a significant pelvic obliquity, severe pain with hip range of motion, and limited hip range of motion. Imaging studies revealed a complete loss of articular cartilage and significant joint effusion.
The patient underwent THA. No postoperative complications occurred. Two-year follow-up showed an excellent clinical result. The patient’s hip was pain free, and he was able to walk with no limp.
The authors are unaware of any reported cases of children with osteogenesis imperfecta undergoing THA. Based on the reported literature and the authors’ experience, THA can be a reliable surgical option for patients with osteogenesis imperfecta.
Three-part Head-splitting Proximal Humerus Fracture Through a Unicameral Bone Cyst
Authors: Younghein John A. , Eskander Mark S. , DeAngelis Nicola A. , Wixted John J. 
Published: June 2012

Unicameral bone cysts are rare in adults and are most often found incidentally on radiographs. However, they can persist from the adolescent period and may be present in locations that predispose to or exacerbate fractures.
This article describes a case of a healthy 40-year-old woman who sustained a proximal humerus trauma that involved a large unicameral bone cyst, resulting in a 3-part head-splitting fracture. The epiphyseal location of the cyst contributed to the severity and extent of the fracture that resulted from a simple fall. Given the age of the patient, open reduction and internal fixation with a locking plate and lag screws was performed. The patient chose open reduction and internal fixation to preserve a hemiarthroplasty procedure in case of future revision. Successful humeral head reconstruction was achieved, and the patient fully recovered. One year postoperatively, the patient underwent arthroscopic debridement to alleviate subjective stiffness and decreased range of motion.
Multipart head-splitting fractures require complex repair strategies. The gold standard for the treatment of these injuries is hemiarthroplasty. However, the decision process is difficult in a young patient given the average survival of autoplastic prostheses and the added difficulty of later revision. The current case demonstrates the complexity of decision making resulting from a rare injury in a young, healthy patient and shows that open reduction and internal fixation can provide acceptable reconstruction in such situations.
Simulated Effect of Corneal Asphericity Increase (Q-factor) as a Refractive Therapy for Presbyopia
Authors: Amigo Alfredo , Bonaque Sergio , López-Gil Norberto , Thibos Larry 
Published: June 2012

PURPOSE:
To determine the theoretical effect of an increase in the negative Q-factor (hyperprolateness) on the refractive state and its effect on presbyopia treatment.

METHODS:
Ray tracing software was used to simulate the Navarro eye model. To simulate refractive therapy, corneal Q-factor ranged from 0 to −1.50. Refractive state of the model eye was defined as the target vergence required to maximize retinal image quality according to several image quality metrics. The change of refractive state produced by pupil constriction from 6 to 2 mm was estimated.

RESULTS:
For 0⩾Q⩾−0.6, spherical aberration of the model eye is positive, therefore, pupil miosis causes a hypermetropic shift in refractive state. Over the range −0.6⩾Q⩾−1.5, spherical aberration becomes negative and pupil constriction causes the eye’s far point to approach the eye, inducing a myopic shift. A maximum 0.60-diopter myopic shift in refractive state due to pupil constriction occurred for Q=−1.25.

CONCLUSIONS:
Optical modeling predicts that surgically induced negative corneal Q-value will produce a change in the refractive state of the eye after pupillary miosis.
Synthesis of a Modified PC70BM and Its Application as an Electron Acceptor with Poly(3‐hexylthiophene) as an Electron Donor for Efficient Bulk Heterojunction Solar Cells
Authors: Singh Surya Prakash , Kumar CH. Pavan , Sharma G. D. , Kurchania Rajnish , Roy M. S. 
Published: June 2012

AbstractA simple and effective modification of phenyl‐C70‐butyric acid methyl ester (PC70BM) is carried out in a single step after which the material is used as electron acceptor for bulk heterojunction polymer solar cells (PSCs). The modified PC70BM, namely CN‐PC70BM, showed broader and stronger absorption in the visible region (350–550 nm) of the solar spectrum than PC70BM because of the presence of a cyanovinylene 4‐nitrophenyl segment. The lowest unoccupied molecular energy level (LUMO) of CN‐PC70BM is higher than that of PC70BM by 0.15 eV. The PSC based on the blend (cast from tetrahydrofuran (THF) solution) consists of P3HT as the electron donor and CN‐PC70BM as the electron acceptor and shows a power conversion efficiency (PCE) of 4.88%, which is higher than that of devices based on PC70BM as the electron acceptor (3.23%). The higher PCE of the solar cell based on P3HT:CN‐PC70BM is related to the increase in both the short circuit current (Jsc) and the open circuit voltage (Voc). The increase in Jsc is related to the stronger light absorption of CN‐PC70BM in the visible region of the solar spectrum as compared to that of PC70BM. In other words, more excitons are generated in the bulk heterojunction (BHJ) active layer. On the other hand, the higher difference between the LUMO of CN‐PC70BM and the HOMO of P3HT causes an enhancement in the Voc. The addition of 2% (v/v) 1‐chloronapthalene (CN) to the THF solvent during film deposition results in an overall improvement of the PCE up to 5.83%. This improvement in PCE can be attributed to the enhanced crystallinity of the blend (particularly of P3HT) and more balanced charge transport in the device.
Photothermally Sensitive Poly(N‐isopropylacrylamide)/Graphene Oxide Nanocomposite Hydrogels as Remote Light‐Controlled Liquid Microvalves
Authors: Zhu Chun‐Hua , Lu Yang , Peng Jun , Chen Jia‐Fu , Yu Shu‐Hong 
Published: June 2012

AbstractA photothermally sensitive poly(N‐isopropylacrylamide)/graphene oxide (PNIPAM/GO) nanocomposite hydrogel can be synthesized by in situ γ‐irradiation‐assisted polymerization of an aqueous solution of N‐isopropylacrylamide monomer in the presence of graphene oxide (GO). The colors and phase‐transition temperatures of the PNIPAM/GO hydrogels change with different GO doping levels. Due to the high optical absorbance of the GO, the nanocomposite hydrogel shows excellent photothermal properties, where its phase transitions can be controlled remotely by near‐infrared (NIR) laser irradiation, and it is completely reversible via laser exposure or non‐exposure. With a higher GO loading, the NIR‐induced temperature of the nanocomposite hydrogel increases more quickly than with a lower doping level and the temperature can be tuned effectively by the irradiation time. The nanocomposite hydrogel with its excellent photothermal properties will have great applications in the biomedical field, especially as microfluidic devices; this has been demonstrated in our experiments by way of remote microvalves to control fluidic flow. Such an “easy” and “clean” synthetic procedure initiated by γ‐irradiation can be extended for the efficient synthesis of other nanocomposite materials.
Cancer incidence in a chlorochemical plant in Isère, France: An occupational cohort study, 1979–2002
Authors: Bonneterre Vincent , Mathern Gérard , Pelen Odile , Balthazard Anne‐Laure , Delafosse Patricia , Mitton Nicolas , Colonna Marc 
Published: June 2012

AbstractBackgroundA major French chlorine chemical plant (chlor‐alkali process with diaphragm cell and manufacturing of organochlorine chemicals) has used or produced known or suspected carcinogenic compounds.MethodsA cohort study, based on the plant occupational health service and the regional cancer registry, analyzed the standardized incidence ratios of malignant tumors for the period 1979–2002. Individual exposures were estimated from workers' occupational histories in a dual division of jobs into 9 sectors and 115 workshops with known exposures.ResultsMen (2,742) were followed, corresponding to 52,794 person‐years. Primary tumors (304) were observed for 290 expected cases, a non‐significant 5% excess. A significant excess was found of pleural mesothelioma and bladder cancer in employees hired before 1964.ConclusionExcesses of mesothelioma and bladder cancer were found, whereas there was no excess of hematopoietic cancers despite high benzene and dioxin exposures. Surprisingly, mesothelioma cases did not include workers who were the most exposed to asbestos. Am. J. Ind. Med. 55:756–767, 2012. © 2012 Wiley Periodicals, Inc.
Computational and mathematical models of chondrogenesis in vertebrate limbs
Authors: Glimm T. , Headon D. , Kiskowski M. A. 
Published: June 2012

AbstractThe production of cartilage (chondrogenic patterning) in the limb is one of the best‐studied examples of the emergence of form in developmental biology. At the core of the theoretical study is an effort to understand the mechanism that establishes the characteristic distribution of cartilage in the embryonic limb, which defines the future sites and shapes of bones that will be present in the mature limb. This review article gives an overview of the history and current state of a rich literature of mathematical and computational models that seek to contribute to this problem. We describe models for the mechanisms of limb growth and shaping via interaction with various chemical fields, as well as models addressing the intrinsic self‐organization capabilities of the embryonic mesenchymal tissue, such as reaction‐diffusion and mechanochemical models. We discuss the contributions of these models to the current understanding of chondrogenesis in vertebrate limbs, as well as their relation to the varied conceptual models that have been proposed by experimentalists. Birth Defects Research (Part C) 96:176–192, 2012. © 2012 Wiley Periodicals, Inc.
Labeling Small RNAs through Chemical Ligation at the 5′ Terminus: Enzyme‐Free or Combined with Enzymatic 3′‐Labeling
Authors: Vogel Heike , Richert Clemens 
Published: June 2012

AbstractThe discovery of small RNAs such as microRNAs (miRNAs), small interfering RNAs (siRNAs), or Piwi‐associated RNAs (piRNAs) has led to new challenges in the selective detection of RNAs. Many noncoding RNAs act as post‐translational regulators of gene expression and are involved in the regulation of cell proliferation or apoptosis, but are difficult to amplify, label, and detect. Standard microarray detection procedures involve pre‐hybridization labeling or enzymatic 3′‐labeling by polymerase‐catalyzed extension. Dual labeling would improve the fidelity of detection, but no polymerases for 5′‐extension are known. Here we report a novel labeling method for RNAs bearing natural 5′‐phosphate groups, such as miRNAs, based on enzyme‐free ligation of a biotin‐ or fluorophore‐labeled oligonucleotide to the 5′ termini. The method uses in situ activation of the natural 5′‐phosphate groups in these RNAs and was optimized to give near‐quantitative conversion in solution. With use of biotin‐ or fluorophore‐bearing labeling strands, different miRNA sequences were detected on microarrays with little background fluorescence. In combination with an established method of enzymatic on‐chip labeling at the 3′ termini, highly selective detection of related miRNAs was achieved by dual recognition at both termini, even in the case of miRNAs differing in only one nucleotide.
AMG 386 in combination with sorafenib in patients with metastatic clear cell carcinoma of the kidney
Authors: Rini Brian , Szczylik Cezary , Tannir Nizar M. , Koralewski Piotr , Tomczak Piotr , Deptala Andrzej , Dirix Luc Y. , Fishman Mayer , Ramlau Rodryg , Ravaud Alain , Rogowski Wojciech , Kracht Karolyn , Sun Yu‐Nien , Bass Michael B. , Puhlmann Markus , Escudier Bernard 
Published: June 2012

AbstractBACKGROUND:This study evaluated the tolerability and antitumor activity of AMG 386, a peptibody (a peptide Fc fusion) that neutralizes the interaction of angiopoietin‐1 and angiopoietin‐2 with Tie2 (tyrosine kinase with immunoglobulin‐like and EGF‐like domains 2), plus sorafenib in patients with clear cell metastatic renal cell carcinoma (mRCC) in a randomized controlled study.METHODS:Previously untreated patients with mRCC were randomized 1:1:1 to receive sorafenib 400 mg orally twice daily plus intravenous AMG 386 at 10 mg/kg (arm A) or 3 mg/kg (arm B) or placebo (arm C) once weekly (qw). Patients in arm C could receive open‐label AMG 386 at 10 mg/kg qw plus sorafenib following disease progression. The primary endpoint was progression‐free survival (PFS).RESULTS:A total of 152 patients were randomized. Median PFS was 9.0, 8.5, and 9.0 months in arms A, B, and C, respectively (hazard ratio for arms A and B vs arm C, 0.88; 95% confidence interval [CI], 0.60‐1.30; P = .523). The objective response rate (95% CI) for arms A, B, and C, respectively, was 38% (25%‐53%), 37% (24%‐52%), and 25% (14%‐40%). Among 30 patients in arm C who had disease progression and subsequently received open‐label AMG 386 at 10 mg/kg qw, the objective response rate was 3% (95% CI, 0%‐17%). Frequently occurring adverse events (AEs) included diarrhea (arms A/B/C, 70%/67%/56%), palmar‐plantar erythrodysesthesia syndrome (52%/47%/54%), alopecia (50%/45%/50%), and hypertension (42%/49%/46%). Fifteen patients had grade 4 AEs (arms A/B/C, n = 3/7/5); 4 had fatal AEs (n = 2/1/1), with 1 (abdominal pain, arm B) considered possibly related to AMG 386.CONCLUSIONS:In patients with mRCC, AMG 386 plus sorafenib was tolerable but did not significantly improve PFS compared with placebo plus sorafenib. Cancer 2012. © 2012 American Cancer Society.