bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantification of C1 inhibitor activity using a chromogenic automated assay: analytical and clinical performances
Authors: Renaudineau Yves , Sailler Laurent , Puissant-Lubrano Bénédicte 
Published: June 2024

Abstract

Objectives
The quantification of functional C1 inhibitor activity (fC1-INH) is an important tool to diagnose bradykinin-mediated angioedema (AE), whether hereditary or acquired. For that an accurate assay is necessary, therefore we evaluated the analytical performances of a fC1-INH chromogenic assay (Berichrom®, Siemens) performed utilizing an Optilite turbidimeter (Binding Site).

Methods
fC1-INH was quantified by means of the chromogenic assay Berichrom®. Internal quality controls were used to determine the precision of the assay. Stability under various storage and matrix conditions, uncertainty, linearity, interference (of hemolysis, lipemia, and icterus), agreement with the manual Technochrom® assay, and diagnostic performances were further evaluated on samples from patients and healthy donors.

Results
The fC1-INH Berichrom® assay presented good performances regarding intra- and inter-assay precision (CV: 1.3–4.5 % and 3.0–6.0 %, respectively), expanded uncertainty (5.5 % at normal level and 12.5 % at the clinical threshold) and linearity (rho2>0.99: range 7–130 % activity). Addition of interfering substances (hemoglobin <16 g/L, intralipid® <12 g/L, and bilirubin <1 g/L) did not affect fC1-INH quantification. fC1-INH activity from healthy donors remained stable in citrate whole blood until 4 days at room temperature, and 7 days when plasma was collected. Agreement between the automated Berichrom® assay and the manual Technochrom® assay (n=47) was excellent as obtained with both quantitative (Deming regression and Bland–Altman difference plot) and qualitative (Kappa index=1) analyses. Finally, the diagnostic performance of the quantification of fC1-INH for AE evaluated on 81 patients revealed a sensitivity of 100 %, a specificity of 97.2 %, a positive predictive value of 83.3 % and a negative predictive value of 100 %.

Conclusions
The automated fC1-INH Berichrom® assay showed good performance, both at the analytical and diagnostic/clinical levels that allowed its usage in a clinical laboratory for C1-INH-dependent bradykinin-mediated AE research in combination with quantitative C1-INH and C4 determinations.
Analytical validation of the amplification refractory mutation system polymerase chain reaction-capillary electrophoresis assay to diagnose spinal muscular atrophy
Authors: Yao Mei , Jiang Liya , Yan Yue , Yu Yicheng , Chen Yuwei , Wang Xiaoyi , Feng Yijie , Cui Yiqin , Zhou Dongming , Gao Feng , Mao Shanshan 
Published: June 2024

Abstract

Objectives
Spinal muscular atrophy (SMA) is a neuromuscular disorder caused by homozygous deletion and compound heterozygous mutations in survival motor neuron 1 (SMN1), with severity tied to the copy number of survival motor neuron 2 (SMN2). This study aimed to develop a rapid and comprehensive method for the diagnosis of SMA.

Methods
A total of 292 children with clinically suspected SMA and 394 family members were detected by the amplification refractory mutation system polymerase chain reaction-capillary electrophoresis (ARMS-PCR-CE) method, which targeted 19 reported mutations, and the results were compared with those in multiplex ligation-dependent probe amplification (MLPA). Individuals with identified point mutations were further confirmed by SMN1 long-range PCR and Sanger sequencing.

Results
A total of 202 children with SMA, 272 carriers, and 212 normal individuals were identified in this study. No difference was found in the R-value distribution of exons 7 and 8 in SMN1 and SMN2 among these cohorts, with coefficients of variation consistently below 0.08. To detect exon 7 and 8 copy numbers in SMN1 and SMN2, the ARMS-PCR-CE results were concordant with those of MLPA. Approximately 4.95 % (10/202) of the study patients had compound heterozygous mutations.

Conclusions
The ARMS-PCR-CE assay is a comprehensive, rapid, and accurate diagnostic method for SMA that simultaneously detects copy numbers of exons 7 and 8 in SMN1/SMN2, as well as 19 point mutations in SMN1 and 2 enhancers in SMN2. This approach can effectively reduce the time frame for diagnosis, facilitating early intervention and preventing birth defects.
ΛΥΣΙΜΕΛΗΣ: Überlegungen zu existenzieller Körperlichkeit und literarischen Strategien von Homer bis Platon
Authors: Kuhn-Treichel Thomas 
Published: June 2024

AbstractThe adjective λυσιμελής (“limb-loosening”) and related statements about bodies dissolving or melting are found in Greek literature in an astonishing variety of contexts, above all in relation to sleep, death and erotic desire. The present paper asks what made the idea of (limbs) loosening so attractive for authors and it traces their use from early Greek epic (Homer and Hesiod) through lyric (Archilochus, Alcman, Sappho, Ibycus, Anacreon and Pindar) to Plato’sPhaedrus. This brings several factors to light: the adjective and related expressions describe existential experiences of loss of control in an embodied way that 1) points to real psychosomatic correlations, 2) contributes to vividness in the sense of ‘embodied cognition’ and often 3) switches between the concrete and the metaphorical, with the latter intensifying the expressive potential especially in lyric. At the same time, a gradual shift can be observed from an integrated concept of the body towards a (conceptual) metaphor. This apparently unremarkable adjective and its related notions thus permit a deep insight into both the cultural ideas and the literary strategies of early and classical Greece.
Solitonic solutions and study of nonlinear wave dynamics in a Murnaghan hyperelastic circular pipe
Authors: Althobaiti Saad 
Published: June 2024

Abstract
This research article delves into the intricate domain of nonlinear wave dynamics within the framework of a Murnaghan hyperelastic circular pipe. Thus, the current study makes use of some powerful analytical approaches to examine the propagation of nonlinear elastic waves on a Murnaghan hyperelastic circular pipe. The work is exceptional since it allows for the incorporation of double dispersion terms and material nonlinearity in the controlling nonlinear mode. The study entails a thorough examination of the propagation and interaction of solitons within the Murnaghan hyperelastic medium, providing insights into the distinctive nonlinear wave phenomena manifested by circular pipe configurations. Theoretical insights are substantiated by numerical simulations, presenting a comprehensive understanding of the dynamic responses within these elastic structures. In the end, graphical representations of some of the derived solutions have been provided for clarification. In addition, the reported solutions in the study help researchers working in modern fields of engineering and materials science to obtain valuable insights that can inform the design, analysis, and optimization of materials and structures in contemporary applications.
Synthesis of BaO/NiO/rGO nanocomposite for supercapacitor application
Authors: Anisha Nallathambi , Yuvakkumar Rathinam , Ravi Ganesan , Thambidurai Mariyappan , Velauthapillai Dhayalan 
Published: June 2024

Abstract
Considering the global energy crisis, alternative energy resources requirement is rising gradually. In light of dwindling energy resources, we turn to renewable alternatives. Storing this energy for future utilization remains a pressing endeavor. The ideal storage device should possess intensified energy density, power density, and cyclic stability. In this study, we have synthesized metal oxide with carbon based material nanocomposite such as BaO/NiO, BaO/NiO/rGO through cost effective co-precipitation method and their comparative performance for supercapacitor application were studied. Various characterizations were taken for the above synthesized material. X-ray diffraction (XRD) study confirmed the material formation and their crystallinity of the nanocomposite. BaO has tetragonal structure which was confirmed through JCPDS card number 26-0178 and NiO has rhombohedral structure which was confirmed through JCPDS card number 89-7390. To study electrochemical behaviour of electrode material and its cyclic stability, cyclic voltammetry (CV), galvanostatic charge–discharge (GCD) and electrochemical impedance spectroscopy (EIS) studies was executed. BaO/NiO/rGO possesses 1072 F/g specific capacitance at 0.3 A/g in aqueous 1 M KOH. The electrochemical action of hybrid device was setup and it revealed 224 F/g at 0.3 A/g within the charging potential of 1.6 V. Capacitive retention of 97.6 % was achieved by asymmetric hybrid supercapacitor even after 5000 cycles at 10 A/g, this shows prepared nanocomposite exceptional cyclic stability in energy storage application.
Understanding interpreters' ad hoc knowledge: An empirical study based on English–Chinese simultaneous interpreting
Authors: Li Lan , Chai Mingjiong 
Published: June 2024

AbstractThis study investigates ad hoc knowledge in interpreting – knowledge specifically relevant to an interpreting task, usually acquired by interpreters at pre-service and in-service stages. A quasi-experiment asked eight English–Chinese professional interpreters to prepare for and interpret two speeches with different degrees of specialisation. Five datasets were collected: (1) screen and video recordings of their preparation processes; (2) their responses to a follow-up questionnaire; (3) their scores and answers on a domain knowledge test; (4) their interpreting performance, rated by both professional interpreters and domain experts; (5) the speaker's answers to a few open questions on domain knowledge. Parts of the first and second datasets were used to examine what ad hoc knowledge the interpreters needed; the remaining three datasets, together with recording data from the first, were used to investigate the extent of their need for this knowledge. The findings show that ad hoc knowledge is domain-relevant, yet its scope is highly interpreting-specific, being neither deep nor wide; and it is by nature different from domain knowledge, mainly including speech-relevant expressive knowledge about certain domain(s) and the contextual knowledge interpreters use in their preparation. The implications of these findings for interpreting practice and training are also discussed.
Exploring automatic methods for the construction of multimodal interpreting corpora. How to transcribe linguistic information and identify paralinguistic properties?
Authors: Wang Xiaoman , Wang Binhua 
Published: June 2024

AbstractIn corpus-based interpreting studies, typical challenges exist in the time-consuming and labour-intensive nature of transcribing spoken data and in identifying prosodic properties. This paper addresses these challenges by exploring methods for the automatic compilation of multimodal interpreting corpora, with a focus on English/Chinese Consecutive Interpreting. The results show that: 1) automatic transcription can achieve an accuracy rate of 95.3% in transcribing consecutive interpretations; 2) prosodic properties related to filled pauses, unfilled pauses, articulation rate, and mispronounced words can be automatically extracted using our rule-based programming; 3) mispronounced words can be effectively identified by employing Confidence Measure, with any word having a Confidence Measure lower than 0.321 considered as mispronounced; 4) automatic alignment can be achieved through the utilisation of automatic segmentation, sentence embedding, and alignment techniques. This study contributes to interpreting studies by broadening the empirical understanding of orality, enabling multimodal analyses of interpreting products, and providing a new methodological solution for the construction and utilisation of multimodal interpreting corpora. It also has implications in exploring applicability of new technologies in interpreting studies.
Enhancing flotation beneficiation efficiency of complex ores using ionometry methods
Authors: Yakovleva T. A. , Romashev A. O. , Mashevsky G. N. 
Published: June 2024

Flotation beneficiation plays a leading role in the processing most ores. The efficiency of this process is ensured by the correct selection of operating modes, which involves choosing the most selective reagents and determining their optimal consumption. Despite the significance of this issue, the classic approach to determining beneficiation parameters involves testing followed by the processing of the results obtained and the determination of the reagent consumption. However, such studies do not reveal the essence of the physicochemical processes occurring within the pulp, and the results of testing one sample may not correspond to the optimum when the properties of the sample change.The purpose of this work is to develop and implement a methodological approach to the study of ore flotation beneficiation using ionometry methods. The data obtained from ion-selective sensors significantly deepen our insight into the transformations occurring during the flotation process and allow for consideration of possible adverse factors that hinder effective process progression.To achieve this goal, a comparative analysis of two approaches to flotation beneficiation testing was performed using complex sulfide ores as examples. In the first stage, a flotation beneficiation study was conducted through D-optimal factor testing, which included 20 individual tests to determine the optimal consumption of modifying reagents, yielding qualitative indicators. In the second stage, flotation tests were conducted using electrochemical monitoring with pH, Ag2S, Pt, and membrane electrodes. A universal flowchart for flotation studies with ion-selective sensors has been developed, facilitating the application of this approach to various ores. The implementation of the results from this comparative analysis has led to a 7.8% increase in beneficiation efficiency while reducing reagent consumption. Additionally, the insights gained into the electrochemical processes occurring allowed for assumptions about the adverse factors affecting flotation outcomes. In conclusion, a model for the potential application of this approach at existing enterprises was proposed, including the implementation of an “intelligent assistant” for flotation operators based on the developed electrochemical models.
Job Satisfaction among Sherubtse Staff: A Comparative Analysis of Teaching and Non-Teaching Staff
Authors: Kinley Zangmo  
Published: June 2024

Job satisfaction is the fulfilment that an individual derives from employment. The main objective of this study is to assess job satisfaction among teaching and non-teaching staff of Sherubtse College. A quantitative study was conducted to determine job satisfaction. Primary data was collected through random sampling from a total of 39 teaching and 29 non-teaching staff. Out of 68 respondents, 92.6 percent were deemed satisfied, while 7.4 percent expressed dissatisfaction with their current employment status. Data entry and analysis were performed using tests and computations in Statistical Package for Social Sciences (SPSS).
The impact of rehabilitation on the quality of life of patients with vulvovaginal atrophy
Authors: Ampilogova D. M. , Solopova A. G. , Blinov D. V. , Bykovshchenko G. K. , Khlopkova S. V. , Ivanov A. E. 
Published: June 2024

Aim: to evaluate the impact of rehabilitation on various components of quality of life (QoL) in patients with vulvovaginal atrophy (VVA).Materials and Methods. A prospective comparative controlled longitudinal study involved 350 patients with VVA, divided into groups based on the type of menopause: surgical (n = 140) and natural (n = 140), with a control group of 70 women without VVA. Patients were further subdivided into those receiving complex "active" (groups 1A, 2A) and "passive" (groups 1B, 2B) rehabilitation. The study included 6 visits over 24 months, assessing QoL using the Female Sexual Function Index (FSFI), Hospital Anxiety and Depression Scale (HADS), Modified Menopausal Index (MMI), Well-being, Activity, Mood questionnaire (WAM), Magnesium Deficiency Questionnaire (MDQ), and the Assessment Test of Magnesium Deficiency (ATMD).Results. Women with surgical menopause had severe sexual dysfunction initially. Complex "active" rehabilitation significantly improved sexual function over time compared to "passive" rehabilitation. Surgical menopausal women had higher initial levels of anxiety and depression. "Active" rehabilitation significantly reduced these levels, reaching normal values within the first year. Patients with surgical menopause exhibited more severe menopausal symptoms. "Active" rehabilitation led to significant reductions in these symptoms, improved well-being, activity, and mood more significantly than "passive" rehabilitation, particularly in the first year. Complex "active" rehabilitation normalized magnesium deficiency indicators within three months, maintaining normal levels throughout the study.Conclusion. Comprehensive "active" rehabilitation significantly improves sexual function, reduces anxiety and depression, alleviates menopausal symptoms, and enhances overall well-being in women with VVA, especially those in surgical menopause. Personalized rehabilitation programs are crucial for enhancing QoL in these patients.
CBCT an inbound necessity in dentistry
Authors: Rani Anusha , Nagraj  , Sultana Fouzia , Sharma Deepak K , Farhana B  
Published: June 2024

CBCT has become increasingly important in treatment planning and diagnosis in implant dentistry, ENT, orthopedics, and interventional radiology (IR), among other things. Perhaps because of the increased access to such technology, CBCT scanners are now finding many uses in dentistry, such as in the fields of oral surgery, endodontics and rthodontics. Integrated CBCT is also an important tool for patient positioning and verification in image-guided radiation therapy
Comparative analysis of chlorhexidine and listerine mouthwashes on buccal cell health: A clinical and cytological investigation
Authors: Rai Jasuma , Shah Shraddha , Shah Monali , Shah Netra 
Published: June 2024

Mouthwashes are used routinely as adjunct to scaling and root planing. Chlorhexidine mouthwash is known as gold standard while Listerine is a widely used essential oil mouthwash. This study was done to evaluate and compare the genotoxic effect of Listerine with Chlorhexidine mouthwash on buccal cells.It was a parallel design study with 20 participants in each group (Group 1: Chlorhexidine mouthwash and Group 2: Listerine mouthwash). Gingival index was recorded and buccal cells scraping were taken at baseline and 3 weeks after use of respective mouthwashes. The buccal cells were assessed for cytotoxicity using micronuclei test (under microscope at 100 x magnification) using Papanicolaou Stain.There was a statistically significant reduction seen in gingival index from baseline to 3 weeks in both the groups (p&#60; 0.001). There was a statistically significant increase in micronuclei count and number of Micronucleated cells in both the groups from baseline to 3 weeks (p&#60; 0.001). The intergroup analysis showed highly significant increase in micronuclei and Micronucleated cells numbers in Chlorhexidine mouthwash group as compared to Listerine group (p&#60; 0.001).After a 3 weeks exposure, Listerine mouthwash showed less cytotoxicity on buccal cells as compared to Chlorhexidine mouthwash.
Prevalence of mesiodens among nepalese children
Authors: Upadhyay Manisha , Agrawal Ankita , Sharma Jyoti 
Published: June 2024

Mesiodens are considered as one of the most common supernumerary teeth which results in various problems in the oral cavity. However, there have been no studies conducted for establishing the prevalence of same in pediatric population, in Bhairahawa, Nepal. The main objective of the study was to determine the prevalence rate of mesiodens in children between the age group of 4-12 years. Clinical examination and radio vediographs of 1240 patients were investigated. A total of 32 patients were found to have mesiodens/mesiodents’. The study shows a prevalence rate of 2.58% with sex ratio of 15:1 favouring males. Mesiodens is commonly seen supernumerary tooth in children which leads to various problems leading to malocclusion in oral cavity. Early detection and treatment can be helpful in resolution of future problems.
Prawdziwe oblicze świętej Marii Magdaleny — uwagi na marginesie publikacji „Noli me tangere”. Mary Magdalene: One Person, Many Images
Authors: Dutczak Marta 
Published: June 2024

Artykuł jest krytyczną analizą publikacji „Noli me tangere”. Mary Magdalene: One Person, Many Images, powstałą w 2006 r. w ramach interdyscyplinarnego programu badawczego „Mary Magdalene and the Touching of Jesus: An Intra- and Interdisciplinary Investigation of the Interpretation of John 20:17 in Exegesis, Iconography and Pastoral Care”, wspieranego przez Flamandzki Fundusz Badań Naukowych we współpracy z The Centre for Women’s Studies Theology, na Wydziale Teologicznym Katolickiego Uniwersytetu w belgijskim Leuven. Na początku przywołano cztery teksty zawarte w pierwszej części publikacji, w których ich twórcy analizują z perspektywy swoich dyscyplin naukowych znaczenie słów wypowiedzianych w poranek Zmartwychwstania przez Chrystusa do Marii Magdaleny: Sabine Van Den Eynde (egzegeza Biblii hebrajskiej i ksiąg deuterokanonicznych, analiza narracyjna i gender, semantyka), ks. Reimund Bieringer (egzegeza Pism Nowego Testamentu), Karlijn Demasure (teologia praktyczna, duszpasterstwo rodzin) oraz Hannelore Devoldere (teologia pastoralna), Barbara Baert (ikonologia sztuki chrześcijańskiej). W drugiej części artykułu dokonano krytycznego spojrzenia na katalog 29 dzieł ukazujących motyw Noli me tangere, powstałych w czasie od XV do XXI wieku, eksponowanych na towarzyszącej projektowi wystawie w the Maurits Sabbe Library. Zwracając uwagę na odkrywcze aspekty zawartych studiów oraz not katalogowych, m.in.: czytanie postaci Marii Magdaleny w kluczu intertekstualności, wskazanie Magdalenie przez Chrystusa słowami Noli me tangere, aby od tej pory szukała obecności z Nim w sakramentach, różny charakter wymiany spojrzeń między Chrystusem a niewiastą podczas uczty u Szymona i w poranek zmartwychwstania, wskazano na zagrożenia, które niesie ze sobą publikacja. Są nimi przede wszystkim: dopuszczenie analizy tekstu biblijnego w kluczu gender rozumianym jako ideologia będąca w sprzeczności z doktryną katolicką, przeakcentowanie roli wspólnoty wierzących, która ma znaleźć się w centrum po Wniebowstąpieniu Chrystusa, przypisanie Marii Magdalenie przymiotów Maryi (m.in. hortus conclusus) czy też twierdzenie, że jedynie na podstawie świadectwa niewiasty z Magdali, której ukazał się Zmartwychwstały, mógłby być założony Kościół. W zakończeniu znalazło się wskazanie ogólnego kierunku rozważań zawartych w publikacji, który sprowadza się bardziej do interpretowania Kościoła według ludzkich wyobrażeń niż do zgłębiania zamysłu Chrystusa wobec swojego Kościoła.