bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Culture in Affective Empathy: Cultural and Bicultural Differences
Authors: Cassels Tracy G. , Chan Sherilynn , Chung Winnie 
Published: January 2011

Abstract
Empathy is essential for healthy relationships and overall well-being. Affective empathy is the emotional response to others’ distress and can take two forms: personal distress or empathic concern. In Western cultures, high empathic concern and low personal distress have been implicated in increased prosocial behaviour (e.g., Eisenberg et al., 1989) and better emotion management and peer relations (e.g., Eisenberg and Fabes, 1998). Various factors have been examined with respect to affective empathy, but the role of culture has received little attention. Previous work suggests that children from East Asian cultures compared to those from Western cultures experience greater personal distress and less empathic concern (e.g., Trommsdorff, 1995), but no work has specifically examined these differences in adolescents or individuals who identify as ‘bicultural’. The current research examines cultural differences in affective empathy using the Interpersonal Reactivity Index (Davis, 1980) in an adolescent and young adult sample (n=190) and examines how empathy relates to social-emotional health in bicultural individuals. Consistent with research on children, East Asian adolescents reported greater personal distress and less empathic concern than their Western counterparts. The bicultural individuals’ scores fell in between the East Asian and Western groups, but revealed significant differences from their ‘uni-cultural’ peers, demonstrating shared influences of community and family. Importantly, however, the relationship between affective empathy and social-emotional health in bicultural individuals was the same as for Western individuals. The current results provide an important first step in understanding the different cultural influences on empathic responding in a previously understudied population ‐ bicultural individuals.
Classifying ‘Eoliths’: How Cultural Cognition Featured in Arguments Surrounding Claims for the Earliest Human Artefacts as these Developed Between 1880 and 1900
Authors: Ellen Roy , Muthana Angela 
Published: January 2011

Abstract‘Eoliths’ were crude but purportedly humanly worked stones that exercised a great deal of scientific interest between about 1870 and 1930. They became a problem in the context of the debate surrounding the existence of pre-humans in Europe before the beginning of the Pleistocene epoch, and are now mostly reckoned to be of non-human origin. This paper addresses the way in which a network of geologists and prehistorians associated with Benjamin Harrison, the celebrated collector of the first English eoliths, attempted to make sense of barely recognizable artefacts in the period immediately following the establishment of human antiquity in the face of orthodox creationist chronologies. Harrison and his associates did so by innovating a series of criteria, names, categories and crosscutting classifications drawn from their own cultural experience, and typologies available to them through the comparative ethnography of technology. Using concepts and insights developed in cognitive anthropology, we shall attempt to shed light on a controversy in the history of science that has implications for our understanding of the way in which scientists more generally employ ‘provisional classifications’, folk categories and vernacular terminology in order to make sense of domains of intractable data at the frontiers of knowledge.
The Zeus Problem: Why Representational Content Biases Cannot Explain Faith in Gods
Authors: Gervais Will M. , Henrich Joseph 
Published: January 2011

AbstractIn a recent article, Barrett (2008) argued that a collection of five representational content features can explain both why people believe in God and why people do not believe in Santa Claus or Mickey Mouse. In this model ‐ and within the cognitive science of religion as a whole ‐ it is argued that representational content biases are central to belief. In the present paper, we challenge the notion that representational content biases can explain the epidemiology of belief. Instead, we propose that representational content biases might explain why some concepts become widespread, but that context biases in cultural transmission are necessary to explain why people come to believe in some counterintuitive agents rather than others. Many supernatural agents, including those worshipped by other cultural groups, meet Barrett’s criteria. Nevertheless, people do not come to believe in the gods of their neighbors. This raises a new challenge for the cognitive science of religion: the Zeus Problem. Zeus contains all of the features of successful gods, and was once a target for widespread belief, worship, and commitment. But Zeus is no longer a target for widespread belief and commitment, despite having the requisite content to fulfill Barrett’s criteria. We analyze Santa Claus, God, and Zeus with both content and context biases, finding that context ‐ not content ‐ explains belief. We argue that a successful cognitive science of religious belief needs to move beyond simplistic notions of cultural evolution that only include representational content biases.
Implicit Voodoo: Electrodermal Activity Reveals a Susceptibility to Sympathetic Magic
Authors: Hood Bruce M. , Donnelly Katherine , Leonards Ute , Bloom Paul 
Published: January 2011

Abstract
Although young children might be uncertain about the nature of certain representations, most modern adults would explicitly maintain that photographs have no ongoing physical connection the objects that they depict. We demonstrate here in three studies that destruction of a photograph of a sentimental object produces significantly more electrodermal activity than destruction of photographs of other control objects. This response is not attributable to anxiety about being observed whilst destroying the picture, nor is it entirely due to simple visual association ‐ the same response occurs when the photograph does not resemble the object. We suggest that this effect may reflect a tacit acceptance of “sympathetic magic”.
Notch/HES1-mediated PARP1 activation: a cell type–specific mechanism for tumor suppression
Authors: Kannan Sankaranarayanan , Fang Wendy , Song Guangchun , Mullighan Charles G. , Hammitt Richard , McMurray John , Zweidler-McKay Patrick A. 
Published: January 2011

AbstractNotch signaling plays both oncogenic and tumor suppressor roles, depending on cell type. In contrast to T-cell acute lymphoblastic leukemia (ALL), where Notch activation promotes leukemogenesis, induction of Notch signaling in B-cell ALL (B-ALL) leads to growth arrest and apoptosis. The Notch target Hairy/Enhancer of Split1 (HES1) is sufficient to reproduce this tumor suppressor phenotype in B-ALL; however, the mechanism is not yet known. We report that HES1 regulates proapoptotic signals by the novel interacting protein Poly ADP-Ribose Polymerase1 (PARP1) in a cell type–specific manner. Interaction of HES1 with PARP1 inhibits HES1 function, induces PARP1 activation, and results in PARP1 cleavage in B-ALL. HES1-induced PARP1 activation leads to self-ADP ribosylation of PARP1, consumption of nicotinamide adenine dinucleotide+, diminished adenosine triphosphate levels, and translocation of apoptosis-inducing factor from mitochondria to the nucleus, resulting in apoptosis in B-ALL but not T-cell ALL. Importantly, induction of Notch signaling by the Notch agonist peptide Delta/Serrate/Lag-2 can reproduce these events and leads to B-ALL apoptosis. The novel interaction of HES1 and PARP1 in B-ALL modulates the function of the HES1 transcriptional complex and signals through PARP1 to induce apoptosis. This mechanism shows a cell type–specific proapoptotic pathway that may lead to Notch agonist–based cancer therapeutics.
ETV6/RUNX1-positive relapses evolve from an ancestral clone and frequently acquire deletions of genes implicated in glucocorticoid signaling
Authors: Kuster Lilian , Grausenburger Reinhard , Fuka Gerhard , Kaindl Ulrike , Krapf Gerd , Inthal Andrea , Mann Georg , Kauer Maximilian , Rainer Johannes , Kofler Reinhard , Hall Andrew , Metzler Markus , Meyer Lüder Hinrich , Meyer Claus , Harbott Jochen , Marschalek Rolf , Strehl Sabine , Haas Oskar A. , Panzer-Grümayer Renate 
Published: January 2011

Abstract
Approximately 25% of childhood acute lymphoblastic leukemias carry the ETV6/RUNX1 fusion gene. Despite their excellent initial treatment response, up to 20% of patients relapse. To gain insight into the relapse mechanisms, we analyzed single nucleotide polymorphism arrays for DNA copy number aberrations (CNAs) in 18 matched diagnosis and relapse leukemias. CNAs were more abundant at relapse than at diagnosis (mean 12.5 vs 7.5 per case; P = .01) with 5.3 shared on average. Their patterns revealed a direct clonal relationship with exclusively new aberrations at relapse in only 21.4%, whereas 78.6% shared a common ancestor and subsequently acquired distinct CNA. Moreover, we identified recurrent, mainly nonoverlapping deletions associated with glucocorticoid-mediated apoptosis targeting the Bcl2 modifying factor (BMF) (n = 3), glucocorticoid receptor NR3C1 (n = 4), and components of the mismatch repair pathways (n = 3). Fluorescence in situ hybridization screening of additional 24 relapsed and 72 nonrelapsed ETV6/RUNX1-positive cases demonstrated that BMF deletions were significantly more common in relapse cases (16.6% vs 2.8%; P = .02). Unlike BMF deletions, which were always already present at diagnosis, NR3C1 and mismatch repair aberrations prevailed at relapse. They were all associated with leukemias, which poorly responded to treatment. These findings implicate glucocorticoid-associated drug resistance in ETV6/RUNX1-positive relapse pathogenesis and therefore might help to guide future therapies.
The VEGF-regulated transcription factor HLX controls the expression of guidance cues and negatively regulates sprouting of endothelial cells
Authors: Testori Julia , Schweighofer Bernhard , Helfrich Iris , Sturtzel Caterina , Lipnik Karoline , Gesierich Sabine , Nasarre Patrick , Hofer-Warbinek Renate , Bilban Martin , Augustin Hellmut G. , Hofer Erhard 
Published: January 2011

AbstractThe HLX gene encoding a diverged homeobox transcription factor has been found to be up-regulated by vascular endothelial growth factor-A (VEGF-A) in endothelial cells. We have now investigated the gene repertoire induced by HLX and its potential biologic function. HLX strongly increased the transcripts for several repulsive cell-guidance proteins including UNC5B, plexin-A1, and semaphorin-3G. In addition, genes for transcriptional repressors such as HES-1 were up-regulated. In line with these findings, adenoviral overexpression of HLX inhibited endothelial cell migration, sprouting, and vessel formation in vitro and in vivo, whereas proliferation was unaffected. This inhibition of sprouting was caused to a significant part by HLX-mediated up-regulation of UNC5B as shown by short hairpin RNA (shRNA)–mediated down-modulation of the respective mRNA. VEGF-A stimulation of endothelial cells induced elevated levels of HLX over longer time periods resulting in especially high up-regulation of UNC5B mRNA as well as an increase in cells displaying UNC5B at their surface. However, induction of HLX was strongly reduced and UNC5B up-regulation completely abrogated when cells were exposed to hypoxic conditions. These data suggest that HLX may function to balance attractive with repulsive vessel guidance by up-regulating UNC5B and to down-modulate sprouting under normoxic conditions.
IκBζ augments IL-12– and IL-18–mediated IFN-γ production in human NK cells
Authors: Kannan Yashaswini , Yu Jianhua , Raices Raquel M. , Seshadri Sudarshan , Wei Min , Caligiuri Michael A. , Wewers Mark D. 
Published: January 2011

AbstractInterferon-γ (IFN-γ) production by natural killer (NK) cells and cytotoxic lymphocytes is a key component of innate and adaptive immune responses. Because inhibitor of κB-ζ (IκBζ), a Toll-like receptor (TLR)/interleukin-1 receptor (IL-1R) inducible transcription factor, regulates IFN-γ production in KG-1 cells, we tested IκBζ's role in the classic lymphocyte pathway of IL-12/IL-18–induced IFN-γ. Upon stimulation with IL-12/IL-18, monocyte-depleted human peripheral blood lymphocytes expressed the 79-kDa form of IκBζ and released IFN-γ. CD56+ NK cells were shown to be the IκBζ-producing lymphocyte subpopulation, which also released abundant IFN-γ in response to IL-12/IL-18. Importantly, IκBζ was undetectable in CD56− lymphocytes where IFN-γ release was 10-fold lower. In addition, small interfering RNA knockdown of IκBζ suppressed IFN-γ expression in CD56+ cells. The association of IκBζ with the IFN-γ promoter was documented by chromatin immunoprecipitation. IFN-γ promoter activity from IκBζ overexpression was confirmed by luciferase reporter assay. Finally, IκBζ coprecipitated with p65 and p50 NF-κB in NK cells in response to IL-12/IL-18, suggesting that IκBζ's effects on IFN-γ promoter activity are coregulated by NF-κB. These results suggest that IκBζ functions as an important regulator of IFN-γ in human NK cells, further expanding the class of IκBζ-modulated genes.
How I treat: diagnosing and managing “in situ” lymphoma
Authors: Carbone Antonino , Santoro Armando 
Published: January 2011

AbstractThe “in situ” lymphomas are often incidental findings in an otherwise reactive-appearing lymph node. Notably, the risk of progression to clinically appreciable lymphoma is not yet fully known. The diagnosis of “in situ” lymphoma is feasible when immunohistochemical characterization is carried out and genetic abnormalities are assessed. “In situ” follicular lymphoma is characterized by the presence within the affected germinal centers of B cells that strongly express BCL2 protein, a finding that supports their neoplastic nature, in the absence of interfollicular infiltration. In “in situ” mantle cell lymphoma, the lymphoma involvement is typically limited to the inner mantle zone, where lymphoma cells are cyclin D1+ and weakly BCL2+, CD5+. A staging workup to exclude other site of involvement is highly recommended for the possible coexistence of an overt lymphoma. Biopsy of all sites of suspicious involvement should be mandatory. No evidence for starting therapy also in the presence of multifocal “in situ” lymphoma exists, and a “wait-and-see policy” is strongly suggested. A follow-up strategy reserving imaging evaluation only in the presence of disease-related symptoms or organ involvement appears to be a reasonable option. For patients with concomitant overt lymphoma, staging and treatment procedures must be done according to malignant counterpart.
Sleeping arrangement and house structure affect bed net use in villages along Lake Victoria
Authors: Iwashita Hanako , Dida Gabriel , Futami Kyoko , Sonye George , Kaneko Satoshi , Horio Masahiro , Kawada Hitoshi , Maekawa Yoshihide , Aoki Yoshiki , Minakawa Noboru 
Published: January 2011

Abstract

Background
Although insecticide-treated bed nets are effective tools, use often does not follow ownership. House structure and space arrangements may make the attempt to use bed nets difficult, especially for school age children. The objectives of this study were to explore whether an individual's sleeping arrangements and house structure affect bed net use in villages along Lake Victoria in western Kenya.

Methods
Sleeping arrangements of residents were directly observed for use of a bed net, use of a bed, and location. House size, number and types of rooms, bed availability, and residents' ages were estimated. The family heads and mothers were asked about the reason for not using bed nets. Individual bed net use was examined against age and sleeping arrangement. Net use at the household level was examined against four variables: bed availability, bed net availability, house size, and number of rooms.

Results
Bed net use by children between five and 15 years of age was lower than that among the other age classes. However, age was dropped from the final model, and sleeping arrangement was significantly associated with net use. Net use was significantly associated with bed availability, number of rooms and their interaction.

Conclusion
Net use was affected by sleeping arrangement and availability of suitable locations for hanging nets, in addition to net availability. Most residents had likely not realized that sleeping arrangement was a factor in net use. The ease of hanging a net is particularly important for children.
How might ants use panoramic views for route navigation?
Authors: Philippides Andrew , Baddeley Bart , Cheng Ken , Graham Paul 
Published: January 2011

SUMMARY
Studies of insect navigation have demonstrated that insects possess an interesting and sophisticated repertoire of visual navigation behaviours. Ongoing research seeks to help us understand how these behaviours are controlled in natural complex environments. A necessary complement to behavioural studies is an understanding of the sensory ecology within which an animal behaves. To this end we have analysed ants'-perspective views of a habitat within which desert ant navigation is well studied. Results from our analysis suggest that: parsimonious visual strategies for homing and route guidance are effective over behaviourally useful distances even in cluttered environments; that these strategies can function effectively using only the skyline heights as input; and that the simplicity and efficacy of using stored views as a visual compass makes it a viable and robust mechanism for route guidance.
Scaling of mechanical power output during burst escape flight in the Corvidae
Authors: Jackson Brandon E. , Dial Kenneth P. 
Published: January 2011

SUMMARY
Avian locomotor burst performance (e.g. acceleration, maneuverability) decreases with increasing body size and has significant implications for the survivorship, ecology and evolution of birds. However, the underlying mechanism of this scaling relationship has been elusive. The most cited mechanistic hypothesis posits that wingbeat frequency alone limits maximal muscular mass-specific power output. Because wingbeat frequency decreases with body size, it may explain the often-observed negative scaling of flight performance. To test this hypothesis we recorded in vivo muscular mechanical power from work-loop mechanics using surgically implanted sonomicrometry (measuring muscle length change) and strain gauges (measuring muscle force) in four species of Corvidae performing burst take-off and vertical escape flight. The scale relationships derived for the four species suggest that maximum muscle-mass-specific power scales slightly negatively with pectoralis muscle mass (M–0.18m, 95% CI: –0.42 to 0.05), but less than the scaling of wingbeat frequency (M–0.29m, 95% CI: –0.37 to –0.23). Mean muscle stress was independent of muscle mass (M–0.02m, 95% CI: –0.20 to 0.19), but total muscle strain (percent length change) scaled positively (M0.12m, 95% CI: 0.05 to 0.18), which is consistent with previous results from ground birds (Order Galliformes). These empirical results lend minimal support to the power-limiting hypothesis, but also suggest that muscle function changes with size to partially compensate for detrimental effects of size on power output, even within closely related species. Nevertheless, additional data for other taxa are needed to substantiate these scaling patterns.
A latitudinal cline in the efficacy of endogenous signals: evidence derived from retinal cone contraction in fish
Authors: Yammouni Robert , Bozzano Anna , Douglas Ron H. 
Published: January 2011

SUMMARY
Like many physiological systems synchronised to the light:dark cycle, retinomotor movements in ‘lower’ vertebrates are controlled by both the ambient illumination and input from endogenous circadian oscillators. In the present study, we examine the relative influence of these two signals in various species of teleost fish with different latitudes of origin. We find equatorial species show very strong endogenous control. The cones of the glowlight tetra, for example, continue to go through undiminished cycles of contraction and relaxation that mirror the previous light:dark cycle for at least two weeks in continual darkness. To quantify the relative effectiveness of the ambient light compared with endogenous signals in causing cone contraction, the degree to which seven teleost species responded to light during the dark phase of their light:dark cycle was examined. In this situation the retina receives conflicting instructions; while the light is acting directly to cause light adaptation, any endogenous signal tends to keep the retinal elements dark adapted. The further from the equator a species originated, the more its cones contracted in response to such illumination, suggesting animals from higher latitudes make little use of endogenous oscillators and rely more on ambient illumination to control behaviours. Equatorial species, however, rely on internal pacemakers to a much greater degree and are relatively insensitive to exogenous light signals. Because these data are consistent with published observations in systems as diverse as melatonin synthesis in Arctic reindeer and the behaviour of regional populations of Drosophila, latitudinal clines in the efficacy of circadian oscillators may be a common feature among animals.
Color vision and learning in the monarch butterfly,Danaus plexippus(Nymphalidae)
Authors: Blackiston Douglas , Briscoe Adriana D. , Weiss Martha R. 
Published: January 2011

SUMMARYThe monarch butterfly, Danaus plexippus, is well known for its intimate association with milkweed plants and its incredible multi-generational trans-continental migrations. However, little is known about monarch butterflies' color perception or learning ability, despite the importance of visual information to butterfly behavior in the contexts of nectar foraging, host-plant location and mate recognition. We used both theoretical and experimental approaches to address basic questions about monarch color vision and learning ability. Color space modeling based on the three known spectral classes of photoreceptors present in the eye suggests that monarchs should not be able to discriminate between long wavelength colors without making use of a dark orange lateral filtering pigment distributed heterogeneously in the eye. In the context of nectar foraging, monarchs show strong innate preferences, rapidly learn to associate colors with sugar rewards and learn non-innately preferred colors as quickly and proficiently as they do innately preferred colors. Butterflies also demonstrate asymmetric confusion between specific pairs of colors, which is likely a function of stimulus brightness. Monarchs readily learn to associate a second color with reward, and in general, learning parameters do not vary with temporal sequence of training. In addition, monarchs have true color vision; that is, they can discriminate colors on the basis of wavelength, independent of intensity. Finally, behavioral trials confirm that monarchs do make use of lateral filtering pigments to enhance long-wavelength discrimination. Our results demonstrate that monarchs are proficient and flexible color learners; these capabilities should allow them to respond rapidly to changing nectar availabilities as they travel over migratory routes, across both space and time.