bluuebunny/crossref_metadata_2025_split huggingface dataset:
A User-Focused Approach to Evaluating Probabilistic and Categorical Forecasts
Authors: Loveday Nicholas , Taggart Robert , Khanarmuei Mohammadreza 
Published: May 2024

Abstract
A user-focused verification approach for evaluating probability forecasts of binary outcomes (also known as probabilistic classifiers) is demonstrated that (i) is based on proper scoring rules, (ii) focuses on user decision thresholds, and (iii) provides actionable insights. It is argued that when categorical performance diagrams and the critical success index are used to evaluate overall predictive performance, rather than the discrimination ability of probabilistic forecasts, they may produce misleading results. Instead, Murphy diagrams are shown to provide a better understanding of the overall predictive performance as a function of user probabilistic decision threshold. We illustrate how to select a proper scoring rule, based on the relative importance of different user decision thresholds, and how this choice impacts scores of overall predictive performance and supporting measures of discrimination and calibration. These approaches and ideas are demonstrated using several probabilistic thunderstorm forecast systems as well as synthetic forecast data. Furthermore, a fair method for comparing the performance of probabilistic and categorical forecasts is illustrated using the fixed risk multicategorical (FIRM) score, which is a proper scoring rule directly connected to values on the Murphy diagram. While the methods are illustrated using thunderstorm forecasts, they are applicable for evaluating probabilistic forecasts for any situation with binary outcomes.

Significance Statement
Recently, several papers have presented verification results for probabilistic forecasts using so-called categorical performance diagrams, which summarize multiple verification metrics. While categorical performance diagrams measure discrimination ability, we demonstrate how they can potentially lead to incorrect conclusions when evaluating overall predictive performance of probabilistic forecasts. By reviewing recent advances in the statistical literature, we show a comprehensive approach for the meteorological community that (i) does not reward a forecaster who “hedges” their forecast, (ii) focuses on the importance of the forecast user’s decision threshold(s), and (iii) provides actionable insights. Additionally, we present an approach for fairly comparing the skill of categorical forecasts to probabilistic forecasts.
Utilization of Face-to-Face Vestibular Support Groups: A Comparison to Online Group Participation
Authors: Vanstrum Erik B. , Jung Kim Min , Ziltzer Ryan S. , Doherty Joni K. , Bassett Alaina M. 
Published: May 2024

Objective: This study compared the utilization and outcomes of face-to-face (F2F) vestibular support groups and online support communities (OSC) for individuals with vestibular disorders. Methods: We distributed a 31-question anonymous electronic survey through the Vestibular Disorders Association (VeDA) to F2F participants, categorizing user involvement in F2F, OSCs, or both and assessed impact on medical decision-making, psychosocial benefits, and goals achieved. Results: The F2F cohort consisted of 97 individuals comprising primarily of non-Hispanic White women (mean age = 57 years, SD ± 14 years) with diagnoses including persistent postural-perceptual dizziness (19%), Meniere’s disease (15%), and vestibular neuritis (13%). Most participants were diagnosed by an otolaryngologist (65%) and attended F2F meetings monthly or less frequently (78%). The OSC group comprised of 551 individuals, primarily of non-Hispanic White women, but was younger in age (mean age = 50 years, SD ± 13 years). OSC participants notably engaged more, with 36% participating on a daily basis and 32% multiple times a week. F2F participants were older (mean age 57 years vs 50 years, P < .001) and more commonly referred by medical professionals (22% F2F vs 6% OSC, P < .001). Both groups had similar achieved goals, including hearing from others with the same diagnosis (84% vs 89%, P > .05) and similar impact on medical decision-making (75% vs 78%, P > .05). More F2F participants reported increased development of coping skills (79% F2F vs 69% OSC, P = .037). OSC participants typically found the group via an online search (75%), compared to 51% for F2F. OSC participants had higher daily engagement (36%) compared to F2F (1%). Conclusion: F2F users are older and more commonly referred by medical professionals. Despite less frequent engagement, F2F participants reported similar influences on achieved goals, medical decision-making, and impact on psychosocial benefits. These findings highlight the importance of both F2F and OSC support groups for individuals with vestibular disorders.
Comparative evaluation of two different dental age estimation methods using tooth pulp: A CBCT study
Authors: Patel Harmi , Parikh Shilpa J , Shah Jigna S 
Published: May 2024

Aim To estimate the age of an individual based on 3D radiographic evaluation of pulp width of maxillary central incisor. Materials and methods This study included 185 CBCT images of individuals within age range of 14–64 years. Images were evaluated for maxillary central incisors and pulp width measurements were taken from cementoenamel junction and middle third of root. Obtained data was subjected to correlation and regression analysis from which the age of an individual was predicted. Results of the present study were compared with another study by the same authors. Results A negative linear relationship was obtained between age and pulp width. The standard error of estimate (SEE) in sagittal section was 11.36 years and that in coronal section was 11.23 years. The coefficient of determination for sagittal section was 0.107 and for coronal section was 0.127. An obtained regression formula was highly significant. Division of samples into various age groups reduced SEE drastically. Conclusion It can be concluded that pulp width of maxillary central incisor is a reliable indicator of age estimation.
Efficacy of extracorporeal shockwave therapy, compared to corticosteroid injections, on pain, plantar fascia thickness and foot function in patients with plantar fasciitis: A systematic review and meta-analysis
Authors: Cortés-Pérez Irene , Moreno-Montilla Laura , Ibáñez-Vera Alfonso Javier , Díaz-Fernández Ángeles , Obrero-Gaitán Esteban , Lomas-Vega Rafael 
Published: May 2024

Objective To compare the efficacy of extracorporeal shock waves versus corticosteroids injections on pain, thickness of plantar fascia and foot function in patients with plantar fasciitis. Secondarily, to assess the efficacy of radial and focused extracorporeal shock waves and the most appropriated intensity (high, medium or low). Data sources PubMed, SCOPUS, CINAHL and PEDro, until April 2024, according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Review methods Randomized controlled trials comparing the efficacy of extracorporeal shock waves versus corticosteroids injections on pain intensity and sensitivity, thickness of plantar fascia and foot function in patients with plantar fasciitis. Methodological quality and risk of bias were assessed using PEDro Scale and Cochrane Risk of Bias Tool. Pooled effect was calculated using the standardized mean difference (SMD) and its 95% confidence interval (95%CI). Results Sixteen studies involving 1121 patients, showing a mean of 6 points in PEDro scale, were included. At three months, extracorporeal shock waves were better than corticosteroids injections in reducing pain (SMD −0.6; 95%CI −1.1 to −0.11) and thickness of the plantar fascia (SMD −0.4; 95%CI −0.8 to −0.01) and increasing foot function (SMD 0.27; 95%CI 0.12–0.44). At six months, extracorporeal shock waves are more effective in reducing pain (SMD −0.81; 95%CI −1.6 to −0.06) and increasing foot function (SMD 0.67; 95%CI 0.45–0.89). Local pain and slight erythema were the most frequent adverse events. Conclusions Extracorporeal shock waves are a safe therapy, presenting more efficacy than corticosteroids injections in improving pain, thickness of plantar fascia and foot function at mid-term.
The Impact of Model Assumptions on Personalized Lung Cancer Screening Recommendations
Authors: ten Haaf Kevin , de Nijs Koen , Simoni Giulia , Alban Andres , Cao Pianpian , Sun Zhuolu , Yong Jean , Jeon Jihyoun , Toumazis Iakovos , Han Summer S. , Gazelle G. Scott , Kong Chung Ying , Plevritis Sylvia K. , Meza Rafael , de Koning Harry J. 
Published: May 2024

Background Recommendations regarding personalized lung cancer screening are being informed by natural-history modeling. Therefore, understanding how differences in model assumptions affect model-based personalized screening recommendations is essential. Design Five Cancer Intervention and Surveillance Modeling Network (CISNET) models were evaluated. Lung cancer incidence, mortality, and stage distributions were compared across 4 theoretical scenarios to assess model assumptions regarding 1) sojourn times, 2) stage-specific sensitivities, and 3) screening-induced lung cancer mortality reductions. Analyses were stratified by sex and smoking behavior. Results Most cancers had sojourn times <5 y (model range [MR]; lowest to highest value across models: 83.5%–98.7% of cancers). However, cancer aggressiveness still varied across models, as demonstrated by differences in proportions of cancers with sojourn times <2 y (MR: 42.5%–64.6%) and 2 to 4 y (MR: 28.8%–43.6%). Stage-specific sensitivity varied, particularly for stage I (MR: 31.3%–91.5%). Screening reduced stage IV incidence in most models for 1 y postscreening; increased sensitivity prolonged this period to 2 to 5 y. Screening-induced lung cancer mortality reductions among lung cancers detected at screening ranged widely (MR: 14.6%–48.9%), demonstrating variations in modeled treatment effectiveness of screen-detected cases. All models assumed longer sojourn times and greater screening-induced lung cancer mortality reductions for women. Models assuming differences in cancer epidemiology by smoking behaviors assumed shorter sojourn times and lower screening-induced lung cancer mortality reductions for heavy smokers. Conclusions Model-based personalized screening recommendations are primarily driven by assumptions regarding sojourn times (favoring longer intervals for groups more likely to develop less aggressive cancers), sensitivity (higher sensitivities favoring longer intervals), and screening-induced mortality reductions (greater reductions favoring shorter intervals). Implications Models suggest longer screening intervals may be feasible and benefits may be greater for women and light smokers. Highlights Natural-history models are increasingly used to inform lung cancer screening, but causes for variations between models are difficult to assess. This is the first evaluation of these causes and their impact on personalized screening recommendations through easily interpretable metrics. Models vary regarding sojourn times, stage-specific sensitivities, and screening-induced lung cancer mortality reductions. Model outcomes were similar in predicting greater screening benefits for women and potentially light smokers. Longer screening intervals may be feasible for women and light smokers.
Temporal Aspects of Psychosocial Mediators of the Exercise-Weight Loss Maintenance Relationship Within Scalable Behavior-Change Treatments
Authors: Annesi James J. , Powell Sara M. 
Published: May 2024

Study background Limited knowledge of psychological correlates of weight loss is associated with continuing failures of behavioral obesity treatments beyond the short term. Purpose This study aimed to inform health professionals’ obesity interventions via an increased knowledge of mediators of the exercise-weight loss maintenance relationship. Methods Women participated in 6-month obesity treatments within community settings emphasizing moderate exercise and self-regulation skills development via primarily in-person ( n = 54) or primarily written ( n = 54) means. Changes in mood, self-regulating eating, and weight over 6, 12, and 24 months were assessed. A moderated mediation model was tested using the PROCESS macro instruction. Results Improvements in mood, self-regulating eating, and weight were significantly greater in the in-person group. The relationship between a dichotomous measure of completing at least 3 sessions of exercise per week (or not) and change in weight over 6 months was no longer significant when the mediators of changes in negative mood and self-regulation of eating were sequentially entered. Paths of exercise→negative mood reduction→eating self-regulation increase→weight loss over 6, 12 and 24 months were significant. Exercise self-regulation at Month 3 significantly moderated the mood change→eating self-regulation change relationship. Conclusions Based on the identified paths, scalable obesity-treatment content and emphases were informed. This could help guide health professionals’ actions concerning the management of obesity.
Contribution of cellulose nanofibrils on the strengthening and toughening of neat and blended polylactide specimens; and the differences after 3D-printing
Authors: Sarı Burcu , Kaynak Cevdet 
Published: May 2024

The main purpose of this study was to use “green materials” approach by investigating effects of only 1 wt% Cellulose Nanofibrils (CNF) on the strengthening and toughening of neat and blended polylactide (PLA) biopolymer matrix. For this purpose, first of all effects of CNF were investigated in PLA/CNF biocomposite specimens. After blending of PLA with 10 phr bio-based thermoplastic polyester (b-TPE) elastomer, effects of CNF were investigated also for this PLA/b-TPE/CNF ternary biocomposite specimens. Mechanical tests revealed that due to the efficient strengthening and toughening mechanisms, CNF increased flexural strength of PLA by 33%, while b-TPE increased fracture toughness of PLA by 104%. When CNF and b-TPE were incorporated together, synergism in the strength and toughness values were occurred. All bioblend and biocomposite specimens were produced by using the same “melt mixing” technique in a laboratory size twin-screw extruder, and their test specimens were shaped by conventional “compression molding”. Since shaping by “3D-printing” is frequently used in the biomedical sectors, another distinctive aim of this study was to reveal whether there were any differences in the strength and toughness values of specimens after their 3D-printing. It was observed that due to the “textured” structure of 3D-printed specimens, their flexural strength values were approximately 20% lower, while fracture toughness values were approximately 20% higher.
Detection of genetic mutations underlying early-onset systemic lupus erythematosus
Authors: Sener Seher , Sag Erdal , Han Xu , Bilginer Yelda , Zhou Qing , Ozen Seza 
Published: May 2024

Objective We aimed to investigate the presence of monogenic causes of systemic lupus erythematosus (SLE) in our early-onset SLE patients. Methods Fifteen pediatric SLE cases who had early disease onset (≤6 years) were enrolled in this study. All patients fulfilled the Systemic Lupus International Collaborating Clinics (SLICC) criteria. Genomic DNA was used for whole exome sequencing (WES). Pathogenic variants were confirmed by Sanger sequencing. Results The median age at diagnosis of 15 early-onset SLE patients included in the study was 4 (2-6) years (F/M = 12/3). Significant gene mutations were detected in five of these patients (33.3%). Patients 1 and 2 with homozygous DNASE1L3 mutations [ c.320+4_320+7del and G188 A (c.563 G>C) variants] had skin involvement and oral ulcers. One of them (patient 1) had arthritis and nephritis, and another (patient 2) had nonscarring alopecia and thrombocytopenia. They are currently clinically inactive but have positive serological findings. Patient 3 with homozygous pathogenic ACP5 mutation [ G109 R (c.325 G>A) variant] had arthritis, nephritis, short stature, and skeletal dysplasia. Patient 4 with a heterozygote novel IFIH1 mutation [ L809 F (c.2425 C>T) variant] had skin findings and leukopenia. Patient 5 with novel C1S variant [homozygous C147 W (c.441 C>G) variant] had marked skin findings, oral ulcers, nonscarring alopecia, pancytopenia, and low total hemolytic complement CH50 level. All patients have responded to the treatments and have low Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) scores, on therapy. Conclusion Genetic causes should be investigated in early-onset SLE, for better management and genetic counseling. On the other hand, multicenter studies may help to further define genotype-phenotype associations.
A level playing field? Evaluation of the virtual Objective Structured Clinical Examination in Psychiatry and Addiction Medicine: A mixed methods study
Authors: Reay Rebecca E , Maguire Paul A , Looi Jeffrey CL 
Published: May 2024

Objective The Objective Structured Clinical Examination (OSCE) has been used for clinical assessment of a broad range of medical student competencies in Psychiatry and Addiction Medicine. However, there has been little research into online assessments. We investigated the virtual OSCE (v-OSCE) from the user perspective to better understand its acceptability, usefulness, benefits, challenges and potential improvements. Methods At the conclusion of the v-OSCE, all participants (medical students, examiners and simulated patients) were invited to participate in a brief online survey, based on the Technology and Acceptance Model. Freeform qualitative feedback was also obtained to explore participants’ experiences and attitudes. Results Participants reported the v-OSCE was acceptable, efficient, convenient and easy to use. It was perceived as useful for demonstrating students’ interviewing skills and interacting with the simulated patient. Benefits included greater convenience, reduced stress and travel time. Challenges were similar to those experienced in ‘real world’ telepsychiatry, primarily related to assessment of non-verbal cues and emotional prosody. Conclusions Our findings inform recommendations for improving online examinations. These include increased preparation, practice and professionalism, to better simulate the in-person experience. Study credibility was strengthened by the triangulation of qualitative, quantitative and psychometric data.
Communication and Social Determinants of Cancer Preventive Behaviors in Adolescents From Low Socio-Economic Backgrounds in India: A Cross-Sectional Study
Authors: Dhawan Dhriti , McCloud Rachel , Pinnamaneni Ramya , Arora Gaurav , Kadam Rajashree , Dutt Anamika , Biswas-Ramchandran Nandina , Viswanath K. 
Published: May 2024

Purpose Promoting cancer preventive behaviors among adolescents, especially those from lower socioeconomic backgrounds, is crucial due to the significant impact of health behaviors in adolescence on disease risk in adulthood. With India witnessing a rise in cancer incidence and mortality, adolescence becomes a pivotal stage for establishing healthy habits, emphasizing the need for early cancer prevention efforts. Methods This cross-sectional study used survey data from 2242 adolescents attending public schools of Mumbai, India. Multiple logistic regression was conducted to determine the associations between cancer preventive behaviors and: (1) the individual and social determinants of health, and (2) media exposure. Findings Merely 21.5% of the adolescents ate fruits and vegetables daily, 50% of the adolescents exercised 3 or more times a week, and 20% of the adolescents admitted having used tobacco and/or supari. Girls were found to have lower odds of exercising, as well as using tobacco and/or supari. Wealth and father’s education were positively associated with all 3 cancer preventive behaviors. Media exposure was negatively associated, with television exposure linked to reduced fruits and vegetables consumption, while movies and social media exposure were associated with increased tobacco and/or supari use. Interpretation Our findings suggest that individual and social determinants of health and media exposure can influence cancer preventive health behaviors in low socio-economic status (SES) adolescents. Efforts to increase awareness to promote cancer preventive behaviors among the adolescents, particularly low SES adolescents, a population more vulnerable to poor health outcomes, is critical.
Potential Application of Hydrops MR Imaging: A Systematic Review
Authors: Young Yi-Ho , Lin Kao-Tsung 
Published: May 2024

Background Diagnostic dilemma between clinical Meniere’s disease and radiological endolymphatic hydrops (EH) has emerged since the introduction of hydrops magnetic resonance imaging (MRI). The aim of this study is to explore the potential application of hydrops MRI on diagnosing the EH. Methods This review was developed from peer-reviewed articles published in those journals listed on journal of citation reports. The MEDLINE database of the US National Library of Medicine, Scopus, and Google Scholar were used to collect articles based on the guidelines (PRISMA 2020 statement) for reporting reviews. Results Initially, 470 articles were retrieved from 1983 to 2023, and 80 relevant articles were ultimately selected. The sensitivity (69%-92%) and specificity (78%-96%) values varied from each laboratory for detecting EH via hydrops MRI, probably due to candidate selection and the grading system employed. Conclusion The application of hydrops MRI allows (1) differentiation between EH and sudden sensorineural hearing loss; (2) determination of the affected side of EH; and (3) confirmation of the diagnosis of EH concomitant with other disorders. Notably, not all differentials for EH can be visualized on MR images. One of the existing gaps to be filled is that updated hydrops MRI fails to identify distortion, that is, rupture, collapse, fistula, or fibrosis of the inner ear compartments, akin to what histopathological evidence can demonstrate. Hence, enhanced ultrahigh resolution of hydrops MRI is required for demonstrating fine structures of the inner ear compartments in the future.
The Enhanced Anti-anxiety Potentiality and Relevant Material Basis for the Extracts of Bile Processed Coptidis Rhizoma
Authors: Chen Long , Wang Ruifeng , Chen Lin , Zhang Zhenkai , Zhang Bingxian , Wang Yongxiang , Feng Weisheng , Zheng Xiaoke , Li Kai , Zhou Ning 
Published: May 2024

Objective Bile-processed Coptidis Rhizoma (CR) exhibits stronger cold properties and central effect. However, the commonly used bile includes pig/cattle/sheep bile. It is currently unclear which kind of bile performs the best synergistic effect, and the enhanced efficacy is mainly contributed by what components. In this work, a comparative study on pig/cattle/sheep bile processed CR (pCR/cCR/sCR) was carried out. Materials and Methods Firstly, the anxiety model of sthenic heat type was established. Then, pharmacological research involving general state observation, biochemical examination (succinate dehydrogenase, glucokinase, corticosterone, adrenocor ticotropic hormore), pathological evaluation (liver and hippocampus tissue), and behavioral tests (elevated plus maze, open field test) was implemented. Finally, chemical assessment involving high-performance liquid chromatography (HPLC) fingerprints of pCR/cCR/sCR extracts and mass spectrograms of pig/cattle/sheep bile were performed in combination. Results cCR performed the most prominent enhancement in improving hyperactive energy metabolism in liver and abnormal hyperactivity of hypothalamic–pituitary–adrenal axis axis. As for chemical assessment, HPLC fingerprints of pCR/cCR/sCR extracts indicated that alkaloid components detected in cCR extracts were relatively low, mass spectrograms of pig/cattle/sheep bile suggested that bile acids in cattle bile were relatively abundant, and the contents of taurocholic acid, glycocholic acid, and glycodeoxycholic acid were particularly high. Conclusion Cattle bile could be specified as the processing excipient for bile-processed CR, and the high levels of taurocholic acid, glycocholic acid, and glycodeoxycholic acid mainly contributed to the enhanced efficacy of cCR.