bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Triptorelin Combined with Recombinant Human Growth Hormone (rhGH) on Serum Sex Hormones, Bone Age, and Clinical Outcomes in Girls with Precocious Puberty
Authors: Lao Xiaofei , Zhao Lihong , Zhu Xiaoqiang , Yao Xinmei , Chen Huichao 
Published: February 2025

Aims/Background Triptorelin effectively delays bone age progression in children with precocious puberty but may suppress pituitary growth hormone response, affecting growth hormone-binding protein secretion and overall growth rate. This study aimed to evaluate the efficacy and safety of triptorelin alone versus in combination with recombinant human growth hormone (rhGH) in treating girls with precocious puberty. Methods This retrospective study examined 82 girls with precocious puberty treated at The First People’s Hospital of Tongxiang from January 2021 to June 2023. Patients treated with triptorelin alone were assigned to the control group (n = 42), while those treated with triptorelin combined with rhGH formed the study group (n = 40). Both groups received continuous treatment for one year. Outcomes, including efficacy and safety, were compared between the groups. Results Following treatment, height and body mass in the study group were significantly higher than those in the control group (t = 2.126, p = 0.037; t = 2.419, p = 0.018). The bone age/chronological age (BA/CA) ratio in the study group was significantly lower than that in the control group (t = 2.185, p = 0.032). Levels of estradiol (E2), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) in the study group were also significantly reduced compared to the control group (t = 2.208, p = 0.030; t = 4.492, p < 0.001; t = 2.952, p = 0.004). Furthermore, left and right ovarian volumes and uterine volume were significantly lower in the study group than those in the control group (t = 2.740, p = 0.008; t = 2.936, p = 0.004; t = 2.520, p = 0.014). After one year, the effective treatment rate in the study group was higher than that in the control group (97.50% vs 80.95%, p < 0.05). No serious adverse reactions were observed in either group during the treatment period. Conclusion The combination of triptorelin and rhGH demonstrates a clear therapeutic in girls with precocious puberty, which effectively delays bone age growth, regulates sex hormone levels, and reduces ovarian and uterine volumes without severe adverse effects.
The layering construction of the three-dimensional (3D) geological model for Wudalianchi volcanic area, Northeast China
Authors: Jiang Xue , Li Ranran 
Published: February 2025

Establishment of geological model in volcanic area is challenging owing to lack of borehole data and the effect of volcanic activity on rock distribution. Taking full advantage of the existing complete volcanic landforms and recognized for seven eruptive cycles in Wudalianchi volcanic area, here we apply a layered approach to build geological models for meeting rapid development of agriculture and understanding the evolution of regional geological structure. Based on the volcanic eruption cycle, the stratas in Wudalianchi volcanic area are divided into four layers. UGrid (unstructured grid in GMS) is used combining with DEM data to hierarchically build 3D geological structure model of volcanic area, which realize the visualization of regional stratigraphic distribution, and the reliability of the model is verified by the formation mechanisms of different types springs. The stratified modeling provides a scientific and effective mean for the reconstruction of geological structure in volcanic areas where the data are short and the stratigraphic distribution is complex. The 3D geological structure model established can lay a foundation for the prediction, evaluation and sustainable use of regional groundwater, geothermy, mineral water and mineral mud resources.
Innenentwicklung in ländlichen Räumen zwischen Planungsideal und Akteurinteressen: Der Einfluss von sozialen Aspekten
Authors: Gerend Jennifer , Beck Marina 
Published: February 2025

The perspectives of municipal representatives and property owners in three rural communities in Bavaria are the subject of this paper on property and infill development. The results of a survey were assigned to four spatially coded settlement types: historic town centres, post-World-War II settlement types, settlements from the 1980s and 1990s, and new developments after 2000. There were considerable differences between these settlement types in many of the responses: The responses from the newer settlements showed a more individualistic attitude than the respondents in the town centres. For example, vacant lots between buildings are often reserved as plots for grandchildren, others serve as green spaces. Little interest in selling is reported. This paper therefore recommends providing tailored support and incentives that take into account the social aspects of land ownership (including long-term lease options, land swaps, or swaps for units in a new building on the site). The results also show that many vacant lots are perceived in the neighbourhood as welcome green spaces. Therefore, administrations should focus more on planning green spaces in small rural communities and re-evaluating existing properties as potential public green spaces.
Heme iron amplifies azoxymethane initiating effect on rat colon preneoplastic lesions
Authors: Keller Julia , Plaisancié Pascale , Fouché Edwin , Pralet Edwige-Marie , Naud Nathalie , Blas-Y-Estrada Florence , Maslo Claire , Ahn Ingrid , Chevolleau Sylvie , Meireles Maria-Helena , Héliès-Toussaint Cécile , Pietri Sylvia , Cassien Mathieu , Khoury Laure , Audebert Marc , Pierre Fabrice , Theodorou Vassilia , Olier Maïwenn , Guéraud Françoise 
Published: February 2025

Graphical abstract

Abstract

Objective
Colorectal cancer is a major public health issue for which dietary factors such as red and processed meat consumption seem to play a prominent role. Heme iron, which is present in important concentration in those food products, was reported to play a role in colorectal cancer promotion in animal studies. However, its role in colorectal cancer initiation remains to be established.

Methods
Male Fischer 344 rats were given experimental diets (control diet, ferric citrate-supplemented diet or hemin-supplemented diet) for 2 weeks before being initiated for colon cancer with azoxymethane. Rats were then fed a control diet for 8 weeks. Preneoplastic lesions, lipid peroxidation, genotoxicity and oxidative stress markers, together with gut microbiota, were analyzed.

Results
Heme iron, given in the rat diet for only 2 weeks before the colorectal cancer initiating event, increased two types of preneoplastic lesions in the rat colon, namely aberrant crypt foci and mucin-depleted foci, when compared to a control diet containing the same amount of iron in a non-heminic form. This heme iron concentration in the diet, representative of human consumption, induced at the same time a huge increase in luminal lipid peroxidation, a significant increase in RNA/DNA oxidative damage and an increase in the expression of antioxidant defenses in colon mucosa, accompanied by epithelial cell proliferation together with a reduction in colon mucus cells, and a gut dysbiosis.

Conclusion
These results, obtained in an animal model, suggest that iron, only in its heminic form, has a co-initiating effect on colorectal carcinogenesis.

Significance statement
Heme iron from red meat could play a role in colon cancer initiation in addition to its promoting effect.
Self-Injurious Behavior in Child and Adolescent Psychiatry Inpatient Units: Actual Aspects of the Complex Care Provision
Authors: Lesinskienė Sigita , Afrahi Mariam , Pociūtė Kamilė 
Published: February 2025

Background: Nonsuicidal self-injurious behavior in children and adolescents is a major concern that requires mental health professionals’ attention. The aim of this study is to analyze clinical care aspects of children and adolescents who self-harm in psychiatric hospitals.Materials and methods: In 2023, 30 various specialists from five different child and adolescent psychiatric units in Lithuania were interviewed. The survey used a semistructured interview consisting of twelve questions related to complex clinical care methods of children and adolescents who self-harm. The interview responses were summarized and grouped into 5 categories: assessment and monitoring, methods and consequences of self-injury, safety measures, prevention and treatment, insights from staff.Results: Self-injurious behavior in psychiatric inpatient settings was managed through risk assessment, monitoring, communication, medication, counselling, removal of sharp objects, patient allocation, and a several of other methods such as safety contracts, rewards or alternate pain-inducing or self-harm mimicking stimuli. Despite the hospital’s safety procedures patients frequently devised alternate methods to self-harm, such as hitting and scratching themselves and using nonspecific materials.Conclusions: The management of self-harm in children and adolescents psychiatric settings remains insufficient. Further research is needed to explore alternative ways of managing self-injurious behavior in child and adolescent psychiatric hospitals.
Weather-Related Pediatric Fatalities in the United States: 2001 to 2021
Authors: Stephens Caroline Q. , Cairo Sarah B. , Fallat Mary E. , Melhado Caroline G. , Godfred-Cato Shana , Ong Hilary , Newton Christopher 
Published: February 2025

BACKGROUND AND OBJECTIVES
Major weather and climate disasters are increasing in frequency and severity. How often these events result in child deaths is unknown. We assessed temporal and regional trends in pediatric fatalities due to weather events in the United States over the last 21 years.

METHODS
We conducted an ecological study of weather-related pediatric fatalities between 2001 and 2021 using the National Centers for Environmental Information Storm Events Database. Weather-related fatalities were compared with pediatric fatalities included in the Centers for Disease Control and Prevention Wide-ranging ONline Data for Epidemiologic Research database. The change in the proportion of all-cause pediatric fatalities associated with weather events was assessed over time. The frequency of events occurring in regions with Pediatric Disaster Care Centers of Excellence (COE) was examined.

RESULTS
Between 2001 and 2021, weather events were associated with 1423 pediatric fatalities. Sixty percent of fatalities occurred in male children, with a bimodal distribution in age. Flood/currents accounted for the largest proportion of fatalities (37%, n = 524), followed by cold/ice/winter weather (13%, n = 192), tornadoes (13%, n = 183), heat (12%, n = 168), and hurricanes/storms (11%, n = 155). Although no significant difference was noted in the absolute number of fatalities over time (P = .18), the proportion of all-cause pediatric fatalities associated with weather events increased (P = .006) over the course of the study. Forty-six percent of pediatric fatalities occurred in areas with an associated COE.

CONCLUSIONS
Pediatric fatalities from weather events make up an increasing proportion of childhood deaths. Expansion of health-system infrastructure for pediatric disaster planning and response may mitigate childhood deaths from weather-related disasters.
MORAL-ETHICAL AND PHILOSOPHICAL PRINCIPLES OF MYTHOLOGY
Authors: TARASYUK Larisa , TYMOSHENKO Taras 
Published: February 2025

The article examines the moral and ethical and philosophical principles of mythology. Understanding its philosophical and historical meaning will help to better understand the characteristics and values of different cultures. Despite their antiquity, myths resonate in the modern world. They reflect the values and beliefs of different peoples and eras, and their careful study helps us to better understand ourselves and others.The philosophical aspects of mythology include the analysis of how myths reflect and shape the worldview and values of the societies that created them. Through myths, we can trace the evolution of human thinking from irrational to rational, from magical to scientific worldviews. Myths serve as ‘markers’ of time and place, reflecting the worldview, ethical standards, and social structures of a particular era and culture. They help to identify what values were important to a society, how that society saw its place in the world, and how it tried to explain natural and social phenomena.The study of mythology helps reveal how historical events and socio-cultural changes affect the evolution of mythological ideas and are reflected in mythological stories. This is important for understanding the processes of cultural and intellectual development in society. The study of mythology also helps identify common themes and moral principles underlying various mythological systems, which may indicate the universality of some aspects of human experience and values. Mythology acts as an important source for the study of cultural, philosophical, and historical aspects of society and contributes to the expansion of our understanding of human nature and its history.
Does nose spray addiction exist? A qualitative analysis of addiction components in rhinitis medicamentosa
Authors: Lakatos Lili , Koltai Borbála Gabriella , Ferencz Veronika , Demetrovics Zsolt , Rácz József 
Published: February 2025

AbstractBackground and AimsNasal congestion is a prevalent symptom often alleviated with over-the-counter nasal sprays containing decongestants. Rhinitis medicamentosa (RM), caused by the overuse of decongestants leading to recurrent mucosal swelling, poses a significant challenge for specialists in managing patients. Despite advancements in understanding, research primarily consists of case series with limited data on its impact on quality of life. This qualitative study aimed to explore the effect of nasal spray overuse on quality of life and identify addiction components among individuals with RM.MethodsTwenty participants with RM were interviewed by an otorhinolaryngologist and addiction counsellor. The study employed a qualitative approach utilising directed content analysis and revealed eleven categories, classified into addiction components and distinctive features of nasal spray addiction.ResultsThe analysis revealed the presence of all Griffiths' addiction components in the identified themes. Additionally, sleep disorders, the feeling of suffocation, side effects, illness identity and psychological effects on nasal congestion significantly impair individuals' quality of life.ConclusionThis qualitative study identified key components of addiction in nasal spray overuse and suggested that RM might be conceptualised in the DSM-5 category of “Other (or Unknown) Substance-Related Disorders”, considering the lack of psychoactive effects. Nevertheless, in view of the current findings, it also seems to be plausible to examine the phenomenon in the behavioural addiction framework. The study underscores the need for further research and intervention strategies to address the significant impact of RM on individuals' quality of life.
PRELIMINARY INVESTIGATION INTO THE FORMATION OF LiCo0.8M0.2O2-δ (M = Zr, Ca) AS TRIPLE-CONDUCTING OXIDE CATHODES FOR SOLID OXIDE FUEL CELLS
Authors: Mamsor Muhammad Amirul , Baharuddin Nurul Akidah , Norman Nur Wardah , Somalu Mahendra Rao 
Published: February 2025

A solid oxide fuel cell (SOFC) is an efficient electrochemical energy conversion device with low emissions. The cathode is one of the principal components of an SOFC, responsible for the reduction reaction. Triple conducting (H+/O2–/e–) cathodes are promising due to their enhanced performance, but existing materials like LiCoO2 (LCO) face stability issues at high temperatures caused by a high cobalt content. Hence, the study focused on synthesizing LiCo0.8M0.2O2-δ (M = dopant) using a glycine-nitrate process and introducing dopants (Zr/Ca) to the cobalt site of LCO to improve stability. Synthesized cathode powders were analyzed using a thermal gravimetric analysis (TGA), X-ray diffractometry (XRD), and field emission scanning electron microscopy/energy dispersive X-ray spectrometry (FESEM/EDX) to assess the thermal decomposition behavior, phase and structure formation, and microstructure, respectively. The XRD analysis confirmed a successful synthesis of homogeneous LiCo0.8M0.2O2-δ cathode powders (M = Zr, Ca) at a calcination temperature of 800 °C. The FESEM/EDX analysis indicated homogenous elemental distribution within the powders, with final experimental molar ratios of LiCo0.79Ca0.21O2-δ and LiCo0.78Zr0.22O2-δ for the Ca- and Zr-doped cathodes, respectively. This successful synthesis paves the way for further research on the stability and performance of these doped cathodes in SOFC applications.
On the Present Situation and Implementation Strategy of Enterprise Performance Management
Authors: Li Jinyuan 
Published: February 2025

<p>Performance management is an important means for enterprises to achieve development strategic goals in the new era, but also one of the important measures of effective internal economic control of enterprises, enterprises in the process of development to achieve the stability of their own economic benefits, need to strengthen the internal performance management, and this has a very important role for the future development of enterprises. However, at present, there are still many problems in the process of performance management in some enterprises: the performance management mode is relatively simple, the talent training mechanism needs to be improved, the lack of scientific performance system, and the content of performance plan is unreasonable, which is not conducive to the stable improvement of enterprise economic benefits. In view of this, the article discusses the existing problems of enterprise performance management, and puts forward targeted suggestions and suggestions<span style="font-family: 'Times New Roman';">,</span> Realizing Sustainable Development of Enterprises in the New Era<span style="font-family: 'Times New Roman';">,</span> for our country enterprise performance management work effect improvement to provide reference.</p>
Presence in the Text: Whose, for Whom, How
Authors: Venediktova T. D. 
Published: February 2025

This article explores growing interest in the concept of presence in the humanities today. Technological innovations are argued to have facilitated advancement of a “digital” imagination, fostering a compelling sensory immersion into virtual words and creating the illusion of unmediated contact. This propelled dialogue about materiality and polymodality as implicit characteristics of literary texts, “enactivism” as evoking the “materialities of communication” (H.U. Gumbrecht) growing increasingly influential in literary cognitive studies. In this context the concept of epiphany thus acquired currency in modern theory and artistic practice (from Romanticism to Postmodernism), epiphanic writing prioritizing the co-production of aesthetic experience and advocating closer attention to inferential dynamics and the mimetic, deictic or gestural potential of literary discourse in general. Finally, M. Merleau-Ponty’s notion of style is examined to demonstrate the central object of enactivist literary studies to be the author’s style, studied as an interactive experience, and not as an objectified form.
Peran stakeholder dalam pembangunan kawasan perdesaan Margomarem, Kabupaten Wonosobo
Authors: Ainaqo Ayu Annisa Annasihatul , Masrurun Zam Zam 
Published: February 2025

<span id="docs-internal-guid-7d64b8f0-7fff-c052-c34d-4ba3ecfd3133"><span>Pembangunan kawasan perdesaan merupakan pembangunan antar desa yang dilakukan oleh banyak </span><span>stakeholder</span><span> secara kolaboratif sepanjang tahapan mulai pengusulan, penetapan, perencanaan, perda, pelaksanaan, hingga pelaporan dan evaluasi. Kawasan Perdesaan Margomarem mengintegrasikan lima desa (Maron, Tlogo, Menjer, Larangan Lor, dan Mlandi) di Kabupaten Wonosobo. Penelitian ini bertujuan untuk mengidentifikasi para </span><span>stakeholder</span><span> yang terlibat dan perannya dalam setiap tahap pembangunan Kawasan Perdesaan Margomarem. Dengan menggunakan teknik analisis </span><span>stakeholder mapping</span><span>, hasil penelitian menunjukkan bahwa setiap tahap menunjukkan keterlibatan unsur </span><span>stakeholder</span><span> yang berbeda. Pada tahap awal (pengusulan dan penetapan kawasan) dan akhir (pelaporan dan evaluasi), </span><span>stakeholder</span><span> yang terlibat adalah unsur pemerintah dan masyarakat. Unsur swasta bergabung pada tahap perencanaan pembangunan dan penetapan kebijakan. Pada tahap pelaksanaan pembangunan,</span><span> stakeholder</span><span> yang terlibat yaitu unsur pemerintah, masyarakat, swasta, komunitas, dan akademisi. Pelaksanaan pembangunan merupakan tahap dengan stakeholder yang paling kompleks.</span></span>
Kajian pengukuran performa kota hijau kota metropolitan di Pulau Jawa (studi kasus: Jabodetabek, Kedungsepur, dan Gerbangkertasusila)
Authors: Rachmayati Dina 
Published: February 2025

<p class="Abstract"><span id="docs-internal-guid-6f436dbe-7fff-0df8-599a-43d9ddc311ae"><span>Pendekatan </span><span>Green City Conceptual Framework</span><span> (IHS-GCCF) dan </span><span>Green City Performance Index</span><span> (GCPI) berbasis pada efisiensi energi dan digunakan untuk masukan pengambilan kebijakan oleh pemangku kepentingan dalam pengembangan metropolitan yang lebih berkelanjutan. Kajian ini menerapkan metode tersebut ke tiga kota metropolitan di pulau Jawa yaitu Jabodetabek, Gerbangkertosusila, dan Kedungsepur, yang memiliki karakteristik yang hampir sama sehingga diharapkan dapat menjadi rujukan para pemangku kepentingan untuk mengubah hal-hal yang menjadi bagian indikator yang mempengaruhi performa penilaian kota hijau tiga perkotaan tersebut melalui Green City Action Plan (GCAP). Data pada delapan sektor dianalisis dengan pengukuran Green City Performance yaitu sosial-ekonomi, CO2 dan energi, tata guna lahan, transportasi, persampahan, air bersih, sanitasi, dan kualitas udara. Selanjutnya, dilakukan pembobotan dari ahli dan dinilai berdasarkan nilai 1-5, sehingga didapatkan nilai Green Performance tiap sektor. Dari hasil penelitian diketahui bahwa peningkatan Pendapatan Domestik Bruto (PDRB), infrastruktur permukiman, dan peningkatan kualitas udara mempunyai dampak yang positif terhadap performa kota hijau, sedangkan peningkatan jumlah populasi akan berdampak negatif.</span></span></p>