bluuebunny/crossref_metadata_2025_split huggingface dataset:
Italian validation of the body odor disgust scale
Authors: Liuzza Marco Tullio , Zakrzewska Marta Z. , Olofsson Jonas K. 
Published: June 2024

IntroductionDisgust sensitivity to body odors plays a role in a set of psychological mechanisms supposedly evolved to avoid pathogens. To assess individual differences in body odor disgust, we previously developed the body odor disgust scale (BODS) and validated it in English. The BODS presents six scenarios where disgust could be evoked by smells coming from an internal source and an external source. The present study aimed to validate the BODS in the Italian population and to find further evidence for its structural, construct, and criterion validity.MethodsWe used two large samples (N = 1,050, F = 527; and N = 402, F = 203, respectively) that were representative of the Italian population for sex and age.ResultsAcross these two studies, we confirmed the hypothesized bifactor structure, with all the items loading onto a general body odor disgust sensitivity factor, and on two specific factors related to the internal structure. In terms of construct validity, we found that the BODS converged with pathogen disgust sensitivity of the three-domain disgust scale (TDDS) but was distinct from a general propensity to experience negative emotions. The BODS showed criterion validity in predicting the behavioral intentions toward COVID-19 avoidance behavior, although it did not seem to be incrementally valid when compared to the TDDS pathogen subscale. We also established scalar measurement invariance of the BODS regarding gender and found that women display higher levels of BODS.DiscussionResults from the Italian version of the BODS indicate its structural, construct, nomological and criterion validity. Furthermore, our result on sex differences in disgust sensitivity are consistent with previous literature, and we discuss them in the broader context of cross-cultural and primate findings that points toward a possible evolutionary explanation of this difference.
Investigation of vascular risk factor control and secondary prevention medication compliance in acute ischemic stroke
Authors: Chen Yun , Zhang Yuan , Jiang Lianyan , Lu Yanbin , Ding Xiaojie , Jin Wei , Xiong Canxin , Huang Daping 
Published: June 2024

ObjectivesThis study aimed to investigate the management of vascular risk factors, with a specific focus on understanding the various factors affecting risk factor control through an in-depth analysis of clinical data and a longitudinal follow-up of patients who have experienced ischemic strokes.MethodsA total of 1,572 participants were included in the analysis. We assessed thresholds for blood pressure (BP), low-density lipoprotein cholesterol (LDL-C), and glycated hemoglobin (HbA1c) levels to uncover the contextual conditions and factors affecting vascular risk factor control. Moreover, the study also scrutinized medication compliance at intervals of 3, 6, and 12 months post-onset. Logistic regression was used to adjust for confounding factors.ResultsAt 3, 6, and 12 months, BP,LDL, hemoglobin control targets were achieved in 50.7, 51.8, and 50.6%; 51.5, 59.4, and 50.6%; 48.1, 44.0, and 48.4%,respectively. Notably, age was associated with the achievement of BP control (odds ratio [OR], 0.96; 95% confidence intervals [CI], 0.94–0.98; p &lt; 0.0001). Ethnic minorities (OR, 4.23; 95% CI, 1.19–15.09; p = 0.02) and individuals with coronary heart disease (OR, 0.5; 95% CI, 0.3–1.0; p = 0.05) experienced decreased BP control ratios. A previous history of stroke (OR, 1.7; 95% CI, 1.0–2.8; p = 0.03) and unrestricted alcohol consumption (OR, 3.3; 95% CI, 1.0–11.1; p = 0.05) was significantly associated with the achievement of lipid control. Furthermore, lifestyle modifications were significantly correlated with the achievement of BP control (OR, 0.19; 95% CI, 0.12–0.30; p &lt; 0.01), blood glucose control (OR, 0.03; 95% CI, 0.01–0.08; p &lt; 0.01), and blood lipid control (OR, 0.26; 95% CI, 0.16–0.42; p &lt; 0.01). The absence of regular physical activity was associated with lower rates of glycemic (OR, 0.14; 95% CI, 0.06–0.36; p &lt; 0.01) and lipid controls (OR, 0.55; 95% CI, 0.33–0.90; p = 0.01). Over time, overall medication compliance declined.ConclusionWithin the cohort of patients under medication, the compliance rate concerning vascular risk factors remains unsatisfactory. Attention should be paid to compliance with secondary prevention medications and enhance the control of vascular risk factors, as compliance emerges as the key to effective prevention.
Acupuncture as adjunctive treatment for linezolid-induced peripheral neuropathy: a case series report
Authors: Mo Yuping , Nie Fan , Wu Jiahui , Li Linna , Zhu Zhu , Deng Guofang , Fu Liang 
Published: June 2024

BackgroundThe treatment of multidrug-resistant tuberculosis (MDR-TB) and pre-extensively drug-resistant tuberculosis (pre-XDR-TB) remains challenging due to the limited availability of effective drugs. Linezolid has emerged as a promising therapeutic option for these cases. However, its long-term use can lead to complications such as peripheral and optic neuropathies. Acupuncture, a cornerstone of traditional Chinese medicine, has been shown to be effective in the treatment of peripheral neuropathy (PN). This study examines the potential benefits of acupuncture in the treatment of linezolid-induced peripheral neuropathy (LIPN).MethodsFour patients, aged 27 to 60 years, diagnosed with LIPN, underwent daily acupuncture treatments. The main endpoint was to assess the efficacy of acupuncture in reducing neuropathic pain associated with LIPN in patients. This was primarily measured using changes in the Short Form McGill Pain Questionnaire (SF-MPQ) scores before and after acupuncture treatment.ResultsThree of the patients experienced significant symptom remission, while one experienced marginal improvement. Treatments ranged from 7 to 18 sessions. Specifically, the first patient reported substantial relief with a score reduction from 33 to 13; the second patient observed minimal change; the third patient’s score decreased dramatically from 10 to 2 after eight sessions; the last patient had a score reduction from 21 to 12 after five sessions, but did not continue treatment for a second assessment.ConclusionAcupuncture is a promising therapeutic approach for LIPN. However, larger and more thorough studies are needed to determine its full potential.
EEGGAN-Net: enhancing EEG signal classification through data augmentation
Authors: Song Jiuxiang , Zhai Qiang , Wang Chuang , Liu Jizhong 
Published: June 2024

BackgroundEmerging brain-computer interface (BCI) technology holds promising potential to enhance the quality of life for individuals with disabilities. Nevertheless, the constrained accuracy of electroencephalography (EEG) signal classification poses numerous hurdles in real-world applications.MethodsIn response to this predicament, we introduce a novel EEG signal classification model termed EEGGAN-Net, leveraging a data augmentation framework. By incorporating Conditional Generative Adversarial Network (CGAN) data augmentation, a cropped training strategy and a Squeeze-and-Excitation (SE) attention mechanism, EEGGAN-Net adeptly assimilates crucial features from the data, consequently enhancing classification efficacy across diverse BCI tasks.ResultsThe EEGGAN-Net model exhibits notable performance metrics on the BCI Competition IV-2a and IV-2b datasets. Specifically, it achieves a classification accuracy of 81.3% with a kappa value of 0.751 on the IV-2a dataset, and a classification accuracy of 90.3% with a kappa value of 0.79 on the IV-2b dataset. Remarkably, these results surpass those of four other CNN-based decoding models.ConclusionsIn conclusion, the amalgamation of data augmentation and attention mechanisms proves instrumental in acquiring generalized features from EEG signals, ultimately elevating the overall proficiency of EEG signal classification.
A bibliometric analysis based on hotspots and frontier trends of positron emission tomography/computed tomography utility in bone and soft tissue sarcoma
Authors: Xiang Feifan , Zhang Yue , Tan Xiaoqi , Zhang Jintao , Li Tengfei , Yan Yuanzhuo , Ma Wenzhe , Chen Yue 
Published: June 2024

PurposeThis study aimed to analyze articles on the diagnosis and treatment of bone and soft tissue sarcoma using positron emission tomography (PET)/computed tomography (CT) published in the last 13 years. The objective was to conduct a bibliometric analysis and identify the research hotspots and emerging trends.MethodsWeb of Science was used to search for articles on PET/CT diagnosis and treatment of bone and soft tissue sarcoma published from January 2010 to June 2023. CiteSpace was utilized to import data for bibliometric analysis.ResultsIn total, 425 relevant publications were identified. Publications have maintained a relatively stable growth rate for the past 13 years. The USA has the highest number of published articles (139) and the highest centrality (0.35). The UDICE-French Research Universities group is the most influential institution. BYUN BH is a prominent contributor to this field. The Journal of Clinical Oncology has the highest impact factor in the field.ConclusionThe clinical application of PET/CT is currently a research hotspot. Upcoming areas of study concentrate on the merging of PET/CT with advanced machine learning and/or alternative imaging methods, novel imaging substances, and the fusion of diagnosis and therapy. The use of PET/CT has progressively become a crucial element in the identification and management of sarcomas. To confirm its efficacy, there is a need for extensive, multicenter, prospective studies.
Efficacy and safety analysis of combination therapy based on mitoxantrone hydrochloride liposome injection (Lipo-MIT) in relapsed/refractory NK/T-cell lymphoma
Authors: Wang Xing-long , Wang He-nan , Yang Lei , Yang Jing , Cong Jia , Song Zhi-hui , Wang Liang 
Published: June 2024

BackgroundCurrently, there is no standard treatment for relapsed/refractory NK/T-cell lymphoma (NKTCL). Liposomal mitoxantrone (Lipo-MIT) showed good anti-tumor effect in patients with NKTCL, breaking the limitation of natural resistance of NKTCL to anthracyclines. To further improve the efficacy, we tried a combination therapy based on Lipo-MIT in patients with relapsed/refractory NKTCL.Methods12 patients with relapsed/refractory NKTCL were enrolled in this retrospective study, all of whom had previously received pegaspargase-based treatments. The salvage treatment was a combination regimen based on Lipo-MIT. The efficacy was evaluated after every two cycles.Results11 patients had stage IV NKTCL, and all but one patients had an NRI score of ≥3. The median previous lines of treatment was two (range, 1–4), and five patients were refractory to their last line of treatment. The best response rates were as follows: complete response (CR) in five (41.7%) patients, partial response in five (41.7%) patients, stable disease in one (8.3%) patient, and progressive disease in one (8.3%) patient. At a median follow-up of four months (range, 2–14), seven patients died, with a median PFS of five months and a median OS of seven months. The six-month PFS and OS rate was 44.4% and 52.1%, respectively. All patients had suffered from side effects, among which myelosuppression was most reported. Nine patients had grade three or more myelosuppression, and the median recovery time from myelosuppression was 14 days (2–35 days). Five patients had obvious skin hyperpigmentation, and the CR rate was significantly higher compared with those without skin hyperpigmentation (80% vs. 14.3%, p=0.023). Other side effects included liver insufficiency (N=4), coagulation dysfunction (N=4), acute pancreatitis (N=2), and immunotherapy-related adverse effects (irAEs, N=2).ConclusionCombination therapy based on Lipo-MIT has a high remission rate for relapsed/refractory NKTCL, but the duration of remission needs to be further extended. Lipo-MIT has obvious myelosuppression toxicity, and active supportive therapy should be given when combined with other cytotoxic drugs.
Cost-effectiveness analysis of the treatment of posttraumatic stress disorder related to childhood abuse: comparison of phase-based treatment and direct trauma-focused treatment
Authors: van Vliet Noortje I. , Stant A. Dennis , Huntjens Rafaele , van Dijk Maarten K. , de Jongh Ad 
Published: June 2024

BackgroundPolicymakers, health insurers, and health care providers are becoming increasingly interested in cost-effectiveness analyses (CEA’s) when choosing between possible treatment alternatives, as costs for mental health care have been increasing in recent years.ObjectiveThe current study compared the cost-effectiveness and cost-utility of a phased-based treatment approach that included a preparatory stabilization phase with direct trauma-focused treatment in patients with PTSD and a history of childhood abuse.MethodsA cost-effectiveness analysis was conducted based on data from a randomized controlled trial of 121 patients with PTSD due to childhood abuse. A phase-based treatment (Eye Movement Desensitization and Reprocessing [EMDR] therapy preceded by Skills Training in Affect and Interpersonal Regulation [STAIR]; n = 57) was compared with a direct trauma-focused treatment (EMDR therapy only; n = 64). The primary outcome of cost-effectiveness was the proportion of patients with remitted PTSD. Quality-adjusted life years (QALY) were used as the primary outcome measure for cost-utility analysis.ResultsAlthough the results of the cost-effectiveness analyses yielded no statistically significant differences between the two groups, the mean societal costs per patient differed significantly between the STAIR-EMDR and EMDR therapy groups (€19.599 vs. €13.501; M cost differences = €6.098, CI (95%) = [€117; €12.644]).ConclusionSTAIR-EMDR is not cost-effective compared with EMDR-only therapy. Since trauma-focused treatment is less time-consuming, non-trauma-focused phase-based, treatment does not seem to be a viable alternative for the treatment of PTSD due to adverse childhood events.Clinical trial registration: https://onderzoekmetmensen.nl/nl/trial/22074, identifier NL5836.
A retrospective chart review to assess the impact of alpha-guided transcranial magnetic stimulation on symptoms of PTSD and depression in active-duty special operations service members
Authors: Bailar-Heath Marybeth , Burke Riley , Thomas Delisha , Morrow Chad D. 
Published: June 2024

IntroductionSpecial Operations Forces service members (SOF) are regularly exposed to traumatic and concussive events, increasing the prevalence of symptoms of post-traumatic stress disorder (PTSD) and depression, shortening potential years of service.MethodsThis retrospective chart review presents preliminary data on a Human Performance Optimization (HPO) program that provided an average of 30 sessions of individualized alpha frequency repetitive transcranial magnetic stimulation (α-rTMS) to active-duty SOF as to reduce symptoms of PTSD and depression following traumatic brain injury. Scores from the PTSD Checklist for DSM-5, PROMIS Depression short form and Perceived Deficits Questionnaire (PDQ) were reviewed.ResultsSignificant reductions were noted after the HPO program in all clinical scales with an average 37% decrease in PCL-5 (p&lt;.01), 11.3% reduction in PROMIS depression T-scores (p&lt;.01), and 45.5% reduction in PDQ scales by session 30 (p&lt;.01), with side effects matching those commonly reported in rTMS. Importantly, the average PCL-5 score decreased from 42.9 to 27 by end of the treatment program, which is below the clinical threshold of 33 for presence of PTSD. For those with depression symptoms scores greater than cut off clinical thresholds at baseline, 46% resolved following treatment.ConclusionThis data provides preliminary support for safe application of α-rTMS for symptom reduction in active-duty special operations military personnel.
Exergames for falls prevention in sheltered homes: a feasibility study
Authors: Stanmore Emma , Eost-Telling Charlotte , Meekes Wytske , Banham Kelly , Chillala Jay , Roy Bibhas , Firth Joseph 
Published: June 2024

IntroductionFalls prevention is a global priority given its substantial impact on older adults and cost to healthcare systems. Advances in telerehabilitation technology such as `exergaming’ show potential for delivering accessible, engaging exercise programs for older adults. This study aimed to establish the feasibility, acceptability and usability of exergaming in sheltered housing.MethodsA mixed-methods study with participants randomised in 2 sheltered housing facilities to intervention (n = 1 home, 12 participants) and control (n = 1 home 2, 12 participants) provided usual care for all, (physiotherapy prescribed strength and balance exercises and falls prevention advice) and a 6-week supervised exergaming programme (MIRA) offered 3 times per week to the intervention group only. At 6 weeks, feasibility, usability and acceptability outcomes were collected and analysed using descriptive statistics; qualitative focus groups with participants and interviews with staff were also completed and thematically analysed to elicit barriers and facilitators to usability and acceptability.ResultsMean exercise per week increased from 10.6 to 14.1 minutes in the control group and 9.6 to 36.8 minutes in the intervention group. All study processes and measures appeared feasible; 72% of those invited consented to taking part and 92% completed 6-week follow-up. Individual domains for the System Usability Scores (SUS) showed participants felt `very confident’ using the system with support (70%), would `like to use exergames frequently’ (50%) and found the system `easy to use’ (90%). However, they also felt they `needed to learn a lot at the beginning’ (40%) and would `need technical support’ (70%) for independent use of the exergames. Mean overall SUS was 63 reflecting moderate usability for independent use. Qualitative data indicated exergames were well received and highlighted motivational and social aspects; costs and set up. Staff also felt exergaming complemented traditional care.DiscussionOur study contributes to the evidence guiding the use of exergames to deliver suitable falls prevention interventions for older adults within sheltered housing in community settings.
The effect of health literacy on health investment intention: a cross-sectional study among petrochemical employees in China
Authors: Wang Delong , Wang Ying , Ma Huifen , Zhao Shichao 
Published: June 2024

BackgroundsIn the petrochemical industry, employees are exposed to various health hazards, which pose serious challenges to their health and hinder the sustainable development of the petrochemical industry. Investing in health has proved a potential strategy to enhance general health. However, global health investment is notably insufficient, mainly due to the public’s limited intention to invest in their health. While past research has identified various determinants of health investment intentions, the relationship between health literacy and health investment intention remains somewhat controversial and needs more empirical validation.ObjectivesThis study aims to assess the level of health literacy and health investment intention among employees in one of China’s largest petrochemical companies and to explore the effect of health literacy on health investment intention.MethodsA cross-sectional study was conducted in a petrochemical company. The valid sample size for this study was 39,911 respondents. Data were collected using a designed questionnaire, including socio-demographic information, questions about health investment intention, and the “2020 National Health Literacy Monitoring Questionnaire.” Several statistical analysis methods were employed, including descriptive analysis, Chi-square test, logistic regression, and multiple linear regression.ResultsThe study disclosed an average health literacy score of 56.11 (SD = 10.34) among employees, with 52.1% surpassing the qualification threshold. The “Chronic Disease” dimension exhibited the lowest qualification rate at 33.0%. Furthermore, 71.5% of the employees expressed an intention to invest in health, yet a significant portion (34.5%) opted for the minimal investment choice, less than 2,000 RMB. Logistic regression analysis indicated a positive correlation between health literacy and health investment intention (OR = 1.474; p &lt; 0.001). This association’s robustness was further indicated by multiple linear regression analyses (β = 0.086, p&lt;0.001).ConclusionThe employees’ health literacy significantly exceeds the national average for Chinese citizens, yet the qualified rate in the “Chronic Disease” dimension remains notably low. A majority of employees have the intention to invest in health, albeit modestly. Furthermore, while health literacy does positively influence health investment intention, this effect is somewhat limited. Accordingly, personalized Health education should be prioritized, with a focus on improving chronic disease knowledge and facilitating the internalization of health knowledge into health beliefs.
Comparing 5G hybrid beamforming in indoor environments—collocated vs distributed mmWave arrays
Authors: Bagheri Alireza , Bencivenni Carlo , Glazunov Andrés Alayón 
Published: June 2024

This paper studies the performance of hybrid digital-analog multi-user multiple-input multiple-output (MU-MIMO) downlink communication based on various antenna systems for 5G applications. The analysis is focused on comprehensive numerical simulations comparing hybrid beamforming schemes for collocated vs distributed phased array antennas (PAA) deployments in two indoor office environments. This study uses measured beamforming radiation patterns from two 28 GHz state-of-the-art PAAs. The channel models employed are the standardized statistical 3GPP 38.901 indoor channel models implemented in the QuaDRiGa software. A beam selection algorithm is implemented to maximize the achievable sum rate, assuming either matched-filtering or zero-forcing precoding. The evaluated figures of merit are the gain of the RF power amplifier, the per-user signal-to-interference-plus-noise ratio (SINR), and the resulting achievable sum-rate capacity. Based on the results, the distributed deployment scenario always shows a higher SINR and achievable sum-rate capacity at the user locations while requiring a lesser amplification of the conducted power. Specifically, the largest PAA with slant-polarized 16 × 4 elements producing 16 horizontal analog beams in combination with zero-forcing digital precoding proved to be the best solution in both open and mixed indoor office environments in absolute values. On the other hand, the array based on the same type of elements but in a more compact realization with 4 × 4 elements, but with beams arranged as 8 horizontal times 2 vertical, offered the most significant relative gains.