bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence, Causes, and Treatment of Neuropathic Pain in Dutch Nursing Home Residents: A Retrospective Chart Review
Authors: van Kollenburg Esther G. P. , Lavrijsen Jan C. M. , Verhagen Stans C. , Zuidema Sytse U. , Schalkwijk Annelies , Vissers Kris C. P. 
Published: July 2012

ObjectivesTo identify the prevalence and causes of neuropathic pain in Dutch nursing home residents; to establish the prevalence of painful and nonpainful diabetic polyneuropathy in a subsample of individuals with diabetes mellitus and central poststroke pain (CPSP) in a subsample of individuals who had a stroke; and to study the prescription of antineuropathic drugs.DesignA descriptive, retrospective, cross‐sectional study conducted by analyzing medical records.SettingData were collected in 12 Dutch nursing homes.ParticipantsThe data were derived from the medical records of 497 residents of chronic long‐term stay and rehabilitation nursing home units.MeasurementsFour groups were defined: actual (at some time in the previous year) neuropathic pain (ANP), possible neuropathic pain (PNP), neuropathic pain in the past (NPP), and no signs of neuropathic pain (NoNP).ResultsThe prevalence of ANP was 10.9% (95% confidence interval (CI) = 8.4–13.8%) and of PNP was 5.6% (95% CI = 3.9–7.9%). The most common causes were CPSP and phantom limb pain. In the subgroup with diabetes mellitus, 6.3% had nonpainful diabetic polyneuropathy, 0.7% had painful diabetic polyneuropathy, and 0.7% had possible painful diabetic polyneuropathy. In the poststroke subsample, 4.7% were identified as having CPSP, and 5.2% were identified as possibly having CPSP. Within the ANP group, 68.5% of the residents received antineuropathic drugs on the day the medical records were examined; 48.1% used anticonvulsants.ConclusionDutch nursing home residents frequently experience neuropathic pain; therefore, neuropathic pain should receive more attention in frail elderly adults.
Associations of Marital Conflict With Emotional and Physiological Stress: Evidence for Different Patterns of Dysregulation
Authors: Lucas‐Thompson Rachel G. 
Published: July 2012

The goal of this study was to explore theoretically suggested but untested links between interparental conflict and stress physiology in late adolescence. A multi‐method study was conducted involving families (n = 42) who previously participated in the University California, Irvine site of the NICHD Study of Early Child Care and Youth Development; adolescents were 17½ years of age on average. Parent report and observer ratings of conflict, adolescent participation in a robust social‐evaluative stressor, and assessment of cortisol, cardiovascular, and emotional functioning were included. Marital conflict was associated with dampened physiological stress responses in adolescence but sensitized emotional responses, suggesting that conflict may be associated with problems integrating and coordinating emotional and physiological responses to stress.
Alveolar osteotomy associated with resorbable non‐ceramic hydroxylapatite or intra‐oral autogenous bone for height augmentation in posterior mandibular sites: a split‐mouth prospective study
Authors: Kawakami Paulo Y. , Dottore Alexandre M. , Bechara Karen , Feres Magda , Shibli Jamil A. 
Published: July 2012

AbstractBackgroundThe presence of the inferior alveolar nerve within the body of the mandible could jeopardize the placement of dental implants. Previous studies have shown that the interpositional osteotomy for posterior mandible ridge augmentation could be a predictable procedure. Nevertheless, there are few prospective, controlled, and randomized studies that evaluated this technique using different bone graft materials.PurposeThis prospective, controlled split‐mouth study evaluated, using tomographic and Resonance Frequency Analyses (RFA), implants placed in the augmented mandibular area.Material and methodsAlveolar augmentation osteotomies were performed bilaterally in 12 partially edentulous mandibular patients in a split‐mouth design. The alveolar segmental osteotomies were assigned in two groups: test group, interpositional non‐ceramic hydroxylapatite bone graft, and control group, interpositional intra‐oral autogenous bone graft. After 6 months healing, implants were placed. The tomographic measurements of bone gain were recorded at baseline and 6 months after surgery, when the implants were placed. At 12 months after osteotomy, RFA were performed for each implant.ResultsThe mean of bone gain 6.5 ± 2.4 mm and 7.0 ± 1.76 mm to control and test group, respectively (P > 0.05). RFA values between groups were similar at baseline and 12 months follow‐up (P > 0.05).ConclusionAlveolar osteotomies associated with sandwich interpositional bone graft, independently of bone graft, resulted in bone formation over a period of 12 months.
HCRP1 expression status is a significant prognostic marker in oral and oropharyngeal cancer
Authors: Perisanidis C , Savarese‐Brenner B , Würger T , Wrba F , Huynh A , Schopper C , Kornek G , Selzer E , Ewers R , Psyrri A , Krainer M , Filipits M 
Published: July 2012

ObjectiveThe hepatocellular carcinoma‐related protein 1 (HCRP1) is a key factor in the degradation of the epidermal growth factor receptor. In this study, we assessed the prognostic significance of HCRP1 expression in patients with oral and oropharyngeal squamous cell carcinoma (OOSCC).MethodsHCRP1 expression was determined by immunohistochemistry on tissue biopsy sections of 111 patients with locally advanced OOSCC undergoing neoadjuvant chemoradiotherapy followed by surgery. The Kaplan–Meier method and Cox regression models were used for survival analyses.ResultsLow HCRP1 expression was associated with poor recurrence‐free survival (P = 0.046) and overall survival (P = 0.03). Multivariate analysis revealed that low HCRP1 expression remained an independent risk factor for relapse (HR 2.98, 95% CI 1.19–7.49, P = 0.02) and death (HR 3.04, 95% CI 1.19–7.79, P = 0.02).ConclusionLow HCRP1 expression was found to be of adverse prognostic significance in patients with OOSCC who received preoperative chemoradiotherapy.
Characterization of VanYn, a novel D,D‐peptidase/D,D‐carboxypeptidase involved in glycopeptide antibiotic resistance in Nonomuraea sp. ATCC 39727
Authors: Binda Elisa , Marcone Giorgia L. , Pollegioni Loredano , Marinelli Flavia 
Published: July 2012

VanYn is a novel protein involved in the mechanism of self‐resistance in Nonomuraea sp. ATCC 39727, which produces the glycopeptide antibiotic A40926, the precursor of the second‐generation dalbavancin, which is in phase III of clinical development. VanYn (196 residues) is encoded by the dbv7 gene within the dbv biosynthetic cluster devoted to A40926 production. C‐terminal His6‐tagged VanYn was successfully expressed as a soluble and active protein in Escherichia coli. The analysis of the sequence suggests the presence of a hydrophobic transmembrane portion and two conserved sequences (SxHxxGxAxD and ExxH) in the extracytoplasmic domain that are potentially involved in coordination of Zn2+ and catalytic activity. The presence of these conserved sequences indicates a similar mechanism of action and substrate binding in VanYn as in VanY, VanX and VanXY Zn2+‐dependent d,d‐carboxypeptidases and d‐Ala‐d‐Ala dipeptidases acting on peptidoglycan maturation and involved in glycopeptide resistance in pathogens. On substrates mimicking peptidoglycan precursors, VanYn shows d,d‐carboxypeptidase and d,d‐dipeptidase activity, but lacks d,d‐carboxyesterase ability on d‐Ala‐d‐Lac‐terminating peptides. VanYn belongs to the metallo‐d,d‐carboxypeptidase family, but it is inhibited by β‐lactams. Its characterization provides new insights into the evolution and transfer of resistance determinants from environmental glycopeptide‐producing actinomycetes (such as Nonomuraea sp.) to glycopeptide‐resistant pathogens (enterococci and staphylococci). It may also contribute to an early warning system for emerging resistance mechanisms following the introduction into clinics of a second‐generation glycopeptide such as dalbavancin.Database
The nucleotide sequence of vanYn is available in the GenBank data base under accession number CAD91202
Intended or Unintended Consequences? The Likely Implications of Raising the Bar for Sexual Dysfunction Diagnosis in the Proposed DSM-V Revisions: 1. For Women with Incomplete Loss of Desire or Sexual Receptivity
Authors: Clayton Anita H. , DeRogatis Leonard R. , Rosen Raymond C. , Pyke Robert 
Published: July 2012

ABSTRACT

Introduction
Combining female sexual desire and arousal disorders is proposed for the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Brotto et al. challenged our findings that the proposed criteria could potentially exclude from diagnosis or treatment a large number of women with distressing loss of function or in sexual desire, because (i) our samples were insufficiently severe; (ii) we sought to retain the current diagnostic criteria, whereas they contend that “the bar should be raised”; and (iii) the current sexual function diagnostic criteria are unreliable.

Aim
Here we provide additional data to support our view suggesting that the proposed criteria would potentially exclude large numbers of women from diagnosis or treatment if they have moderate-to-marked (rather than severe) hypoactive sexual desire disorder (HSDD), or HSDD with incomplete loss of receptivity.

Methods
In nontreatment validation studies of 481 women in North America and Europe, 231 women diagnosed with HSDD only were compared to women with no female sexual desire.

Main Outcome Measures
Clinicians experienced in sexual medicine determined the severity of HSDD using the standard Clinical Global Impression of Severity. Rating scale data were also used, including the clinician-rated Sexual Desire and Interest Inventory-Female and the self-rated Female Sexual Function Index, Changes in Sexual Functioning Questionnaire, Female Sexual Distress Scale, and an e-Diary about desire during sexual events.

Results
The severity of the HSDD was rated by clinicians as generally moderate-to-marked, not mild. The women with HSDD scored as manifestly sexually dysfunctional and significantly sexually distressed, and reported markedly fewer satisfying sexual events compared to age-matched, non-dysfunctional controls, even for those with moderate or milder degrees of severity, providing compelling evidence that our sample of women with HSDD had clinically disordered sexual function. Yet the proposed criteria would apparently allow diagnosis (and therefore treatment) of only severe desire dysfunction.

Conclusion
It would be counterproductive to combine the two disorders, to make individual criteria for the disorders more stringent or to require more such criteria for a diagnosis because such disorders tend to be distinct in presentation, in treatability with currently available therapies, and in logical approaches to be tested to improve therapy.
Genetic associations with C‐reactive protein level and white blood cell count in the KARE study
Authors: Kong M. , Lee C. 
Published: July 2012

SummaryC‐reactive protein (CRP) and white blood cell (WBC) have been utilized as critical markers contributing to acute and chronic inflammation. Genome‐wide associations were examined to identify nucleotide sequence variants associated with the two markers using 8842 individuals in the Korean Association REsource (KARE) study. A total of six and three nucleotide variants turned out to be associated with CRP and WBC (P < 1.42 × 10−7), and they were mutually exclusive. The only common variant associated with CRP was rs2393791 within hepatocyte nuclear factor 1 alpha (HNF1A) gene [minor allele frequency (MAF) = 0.478]. The only common variant associated with WBC [MAF = 0.468] was rs8078723, an intergenic single nucleotide polymorphism located between proteasome 26S subunits non‐ATPase 3 (PSMD3) and colony‐stimulating factor 3 (CSF3) in chromosome 17. The 2 variants were also associated with other inflammation‐related phenotypes (P < 0.05), and each phenotype was associated with the variant rs2393791 or with the variant rs8078723. We suggested that HNF1A gene was associated with CRP, and the region including PSMD3 and CSF3 genes was associated with WBC. The two inflammatory markers appeared to have distinct genetic components. Not only the functions of these two markers but also the functions of the corresponding genetic components might be largely complementary in determining inflammation process.
Interactions Between Temperature and Sugars in the Regulation of Leaf Senescence in the Perennial Herb Arabis alpina L.F
Authors: Wingler Astrid , Stangberg Emma Josefine , Saxena Triambak , Mistry Rupal 
Published: July 2012

AbstractAnnual plants usually flower and set seed once before senescence results in the death of the whole plant (monocarpic senescence). Leaf senescence also occurs in polycarpic perennials; even in “evergreen” species individual leaves senesce. In the annual model Arabidopsis thaliana sugars accumulate in the senescent leaves and senescence is accelerated by high sugar availability. Similar to A. thaliana, sugar contents increased with leaf age in the perennial Arabis alpina grown under warm conditions (22 °C day/18 night). At 5 °C, sugar contents in non‐senescent leaves were higher than at a warm temperature, but dependent on the accession, either sugars did not accumulate or their contents decreased in old leaves. In A. alpina plants grown in their natural habitat in the Alps, sugar contents declined with leaf age. Growth at a cold temperature slightly delayed senescence in A. alpina. In both warm and cold conditions, an external glucose supply accelerated senescence, but natural variation was found in this response. In conclusion, sugar accumulation under warm conditions could accelerate leaf senescence in A. alpina plants, but genotype‐specific responses and interactions with growth temperature are likely to influence senescence under natural conditions.
Setting reference values for exhaled nitric oxide: a systematic review
Authors: Jacinto Tiago , Alving Kjell , Correia Ricardo , Costa‐Pereira Altamiro , Fonseca João 
Published: July 2012

AbstractBackgroundThe values obtained when the fraction of exhaled nitric oxide (FeNO) is measured are affected by several factors that are specific to the individual patient, making interpretation difficult, especially in the initial assessment of patients with respiratory symptoms.MethodsSystematic review of studies on FeNO reference values and individual‐specific factors that influence them.ResultsFrom 3739 references, 15 studies were included. Four studies included children and adolescents. In nine studies, samples were selected from the general population. Most studies reported objective measures for atopy (nine studies), but not for smoking status (one). Significant determinants of FeNO values reported were age and height (seven studies), atopy (six), smoking (four), weight (four), sex (three) and race (three). Additional factors were included in eight studies. R2 was reported in only five studies. The logarithmic transformation of FeNO was inadequately described in seven studies.ConclusionThere are several equations for FeNO reference values that may be used in clinical practice, although the factors they include and the statistical methods they use vary considerably. We recommend the development of standard methods for the evaluation of normal FeNO data and that reference equations should be formulated based on a predetermined physiological model.
Exercise during cardiac catheterization distinguishes between pulmonary and left ventricular causes of dyspnea in systemic sclerosis patients
Authors: Hager W. David , Collins Irina , Tate Janet P. , Azrin Michael , Foley Raymond , Lakshminarayanan Santha , Rothfield Naomi F. 
Published: July 2012

AbstractObjectiveThe cause for shortness of breath among systemic sclerosis (SSc) patients is often lacking. We sought to characterize the hemodynamics of these patients by using simple isotonic arm exercise during cardiac catheterization.MethodsCatheterization was performed in 173 SSc patients when resting echocardiographic pulmonary systolic pressures were <40 but >40 mmHg post stress. Patients with resting mean pulmonary arterial pressures (mPAP) ≤ 25 and pulmonary arterial wedge pressures (PAWP) ≤ 15 mmHg exercised with 1‐pound hand weights. Normal exercise was defined as a change in mPAP divided by the change in cardiac output (CO) (ΔmPAP/ΔCO) ratio ≤ 2 for patients <50 years (≤3 for >50). An abnormal ΔmPAP/ΔCO ratio, an exercise transpulmonary gradient (TPG) ≥ 15, a PAWP < 20, a ΔTPG > ΔPAWP and a pulmonary vascular resistance (PVR) which increased defined exercise‐induced pulmonary arterial hypertension (EIPAH). An abnormal ΔmPAP/ΔCO ratio, an exercise TPG < 15, a PAWP ≥ 20, a ΔTPG < ΔPAWP and a drop in PVR defined left ventricular diastolic dysfunction (DD). Twelve patients without SSc served as controls.ResultsPulmonary pressures increased with exercise in 53 patients. Six had EIPAH and 47 had DD. With exercise, mPAP and PAWP were 20 ± 4 and 13 ± 2 in controls, 36 ± 3 and 12 ± 4 in EIPAH and 34 ± 6 and 26 ± 4 in DD. Control ΔmPAP/ΔCO was 0.8 ± 0.7, 7.5 ± 3.9 in EIPAH and 9.1 ± 7.2 in DD. Rest and exercise TPG was normal for control and DD patients but increased (12 ± 4 to 23 ± 4) in EIPAH (P < 0.0001). PVR decreased in DD but increased in EIPAH with exercise.ConclusionsExercise during catheterization elucidates the pathophysiology of dyspnea and distinguishes EIPAH from the more common DD in SSc patients.
Careful, Physicalists: Mind–Body Supervenience Can Be Too Superduper
Authors: BALTIMORE JOSEPH A. 
Published: July 2012

AbstractIt has become evident that mind–body supervenience, as merely specifying a covariance between mental and physical properties, is consistent with clearly non‐physicalist views of the mental, such as emergentism. Consequently, there is a push in the physicalist camp for an ontologically more robust supervenience, a “superdupervenience,” that ensures that properties supervening on physical properties are physicalistically acceptable. Jessica Wilson claims that supervenience is made superduper by Condition on Causal Powers (CCP): each individual causal power associated with a supervenient property is numerically identical with a causal power associated with its base property. Furthermore, according to Wilson, a wide variety of physicalist positions, both reductive and non‐reductive, can be seen as relying on CCP to ensure that properties supervening on physical properties are physicalistically acceptable. I argue that imposing CCP on mind–body supervenience fails to ensure that mental properties are physicalistically acceptable. The problem, I contend, is that while CCP may guard against supervenient mental properties being insufficiently grounded in their physical bases it fails to guard against supervenient mental properties being too deeply grounded in their physical bases.
When Do Global Pipelines Enhance the Diffusion of Knowledge in Clusters?
Authors: Morrison Andrea , Rabellotti Roberta , Zirulia Lorenzo 
Published: July 2012

abstractRecent studies have stressed the role played by global pipelines in fostering the growth of clusters and innovativeness. In this article, we develop a formal model to investigate when global pipelines contribute to an increase in local knowledge, depending on various characteristics of clusters such as size, knowledge endowment, and the ease of transmission of internal knowledge. This model is an extension ofCowan andJonard's () model in which we introduce the concept of cluster and a role for spatial proximity in the diffusion of knowledge. Our results reveal that there is a natural tendency of actors within global pipelines to act as external stars, rather than gatekeepers of knowledge. Global pipelines are beneficial for the accumulation of knowledge only if the cluster is either characterized by a high‐quality local buzz or is small and weakly endowed in terms of knowledge.
Developing capable quality improvement leaders
Authors: Kaminski Geraldine M , Britto Maria T , Schoettker Pamela J , Farber Stacey L , Muething Stephen , Kotagal Uma R 
Published: July 2012

Background/objectiveCincinnati Children's Hospital Medical Center created the Intermediate Improvement Science Series (I2S2) training course to develop organisational leaders to do improvement, lead improvement and get results on specific projects.Design methodsEach multidisciplinary class consists of 25–30 participants and 12 in-class training days over 6 months. Instructional methods include lectures, case studies, interactive application exercises and dialogue, participant reports and assigned readings. Participants demonstrate competence in improvement science by completing a project with improvement in outcome and/or process measures. They present on their projects and receive feedback during each session and one-on-one coaching between sessions.ResultsSince 2006, 279 participants in 11 classes have completed the I2S2course. Participant evaluations have consistently rated satisfaction, learning, application, impact and value very high. Large and statistically significant changes were observed in pre-course to post-course self-assessment of knowledge of five quality improvement topics. Approximately 85% of the projects demonstrated measurable improvement. At follow-up, 72% of improvement projects were completed and made a part of everyday operations in the participant's unit or were the focus of continuing improvement work. Many changes were spread to other units or programmes. Most (88%) responding graduates continued to participate in formal quality improvement efforts and many led other improvement projects. Nearly half of the respondents presented their results at one or more professional conference.ConclusionsThrough the I2S2course, the authors are developing improvement leaders, accelerating the shift in the culture from a traditional academic medical centre to an improvement-focused culture, and building cross-silo relationships by developing leaders who understand the organisation as a large system of interdependent subsystems focused on improving health.