bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thermal performance curves for aerobic scope and specific dynamic action in a sexually dimorphic piscivore: implications for a warming climate
Authors: Bihun Christian J. , Stewart Erin M. C. , Lechner Emily R. , Brownscombe Jacob W. , Raby Graham D. 
Published: June 2024

ABSTRACT
Digestion can make up a substantial proportion of animal energy budgets, yet our understanding of how it varies with sex, body mass and ration size is limited. A warming climate may have consequences for animal growth and feeding dynamics that will differentially impact individuals in their ability to efficiently acquire and assimilate meals. Many species, such as walleye (Sander vitreus), exhibit sexual size dimorphism (SSD), whereby one sex is larger than the other, suggesting sex differences in energy acquisition and/or expenditure. Here, we present the first thorough estimates of specific dynamic action (SDA) in adult walleye using intermittent-flow respirometry. We fed male (n=14) and female (n=9) walleye two ration sizes, 2% and 4% of individual body mass, over a range of temperatures from 2 to 20°C. SDA was shorter in duration and reached higher peak rates of oxygen consumption with increasing temperature. Peak SDA increased with ration size and decreased with body mass. The proportion of digestible energy lost to SDA (i.e. the SDA coefficient) was consistent at 6% and was unrelated to temperature, body mass, sex or ration size. Our findings suggest that sex has a negligible role in shaping SDA, nor is SDA a contributor to SSD for this species. Standard and maximum metabolic rates were similar between sexes but maximum metabolic rate decreased drastically with body mass. Large fish, which are important for population growth because of reproductive hyperallometry, may therefore face a bioenergetic disadvantage and struggle most to perform optimally in future, warmer waters.
Guideline-Concordant Surgical Care for Lobular Versus Ductal Inflammatory Breast Cancer
Authors: Iwai Yoshiko , Perez-Rojas Stephany , Thomas Samantha M. , Tadros Audree B. , Woodward Steven G. , Zhang Jennifer Q. , Elmore Leisha C. , Freedman Gary M. , Tchou Julia C. , Bleznak Aaron D. , Fayanju Oluwadamilola M. 
Published: June 2024

Abstract
Introduction
Quality of surgical care is understudied for lobular inflammatory breast cancer (IBC), which is less common, more chemotherapy-resistant, and more mammographically occult than ductal IBC. We compared guideline-concordant surgery (modified radical mastectomy [MRM] without immediate reconstruction following chemotherapy) for lobular versus ductal IBC.

Methods
Female individuals with cT4dM0 lobular and ductal IBC were identified in the National Cancer Database (NCDB) from 2010–2019. Modified radical mastectomy receipt was identified via codes for “modified radical mastectomy” or “mastectomy” and “≥10 lymph nodes removed” (proxy for axillary lymph node dissection). Descriptive statistics, chi-square tests, and t-tests were used.

Results
A total of 1456 lobular and 10,445 ductal IBC patients were identified; 599 (41.1%) with lobular and 4859 (46.5%) with ductal IBC underwent MRMs (p = 0.001). Patients with lobular IBC included a higher proportion of individuals with cN0 disease (20.5% lobular vs. 13.7% ductal) and no lymph nodes examined at surgery (31.2% vs. 24.5%) but were less likely to be node-negative at surgery (12.7% vs. 17.1%, all p < 0.001). Among those who had lymph nodes removed at surgery, patients with lobular IBC also had fewer lymph nodes excised versus patients with ductal IBC (median [interquartile range], 7 (0–15) vs. 9 (0–17), p = 0.001).

Conclusions
Lobular IBC patients were more likely to present with node-negative disease and less likely to be node-negative at surgery, despite having fewer, and more frequently no, lymph nodes examined versus ductal IBC patients. Future studies should investigate whether these treatment disparities are because of surgical approach, pathologic assessment, and/or data quality as captured in the NCDB.
Physical Activity as a Trigger for Anaphylaxis: Understanding Food-Dependent Exercise-Induced Anaphylaxis
Authors: Szewczyk Kamila , Szewczyk Bartłomiej , Hołownia Weronika , Pytel Paulina , Krzesłowska Wiktoria Julia , Wiśniewski Szymon 
Published: June 2024

Introduction:
Food-dependent exercise-induced anaphylaxis (FDEIA) is a distinctive form of anaphylaxis, a severe and potentially life-threatening allergic reaction, that is triggered by physical activity following the consumption of specific food allergens. Unique in its manifestation, FDEIA embodies a complex interaction between food intake and exercise, making it a condition of noteworthy concern particularly among athletes and active individuals.

Aim of the study:
This article endeavors to explore the multifaceted nature of food-dependent exercise-induced anaphylaxis, beginning with a foundational understanding of anaphylaxis and the specific dynamics involved in exercise-induced reactions.

Material and methods:
Literature available in the PubMed database was reviewed using the following keywords: food-dependent exercise induced anaphylaxis; exercise induced-anaphylaxis; food allergies; pathogenesis of FDEIA; diagnosis of FDEIA; sport and anaphylaxis.

Conclusions:
FDEIA is a unique and complex condition that requires a comprehensive understanding for effective management. By exploring its various aspects, from pathophysiology to diagnosis and treatment, we can better equip individuals with the knowledge and tools to navigate this condition and minimize the risk of potentially life-threatening reactions.
The Secretary Problem with Independent Sampling
Authors: Correa José , Cristi Andrés , Feuilloley Laurent , Oosterwijk Tim , Tsigonias-Dimitriadis Alexandros 
Published: June 2024

The secretary problem is probably the most well-studied optimal stopping problem with many applications in economics and management. In the secretary problem, a decision maker faces an unknown sequence of values, revealed successively, and has to make irrevocable take-it-or-leave-it decisions. Her goal is to select the maximum value in the sequence. Although in the classic secretary problem the values of upcoming elements are entirely unknown, in many realistic situations, the decision maker has access to some information, for example, from past data. In this paper, we take a sampling approach and assume that before starting the sequence, each element is sampled independently with probability p. We study both the adversarial and the random arrival models. Our main result is to obtain the best possible algorithms for both settings and all values of p. As p grows to one, the obtained guarantees converge to the optimal guarantees in the full information case. Notably, we establish that the best possible algorithm in the adversarial order setting is a fixed threshold algorithm. In the random order setting, we characterize the best possible algorithm by a sequence of thresholds, dictating at which point in time we should accept a value. Surprisingly, this sequence is independent of p. We complement our theoretical results with numerical experiments on data of people playing the secretary problem repeatedly. Our results help explain some behavioral issues they raised and indicate that people play a strategy similar to our optimal algorithms from the start onwards, albeit slightly suboptimally. This paper was accepted by Chung Piaw Teo, optimization. Funding: This work was partially funded by the Agencia Nacional de Investigación y Desarrollo Chile [Grants FB210005 (Centro de Modelamiento Matamático), AIM23_0004 (Millenium Institute for Research in Market Imperfections and Public Policy), AFB230002 (Instituto Sistemas Complejos de Ingeniería), ACT210005, and Fondo Nacional de Desarrollo Científico y Tecnológico 1220054], the Alexander von Humboldt Foundation with funds from the German Federal Ministry of Education and Research, and the German Research Foundation within the Research Training Group Advanced Optimization in a Networked Economy [Grant Graduiertenkolleg 2201]. The views expressed in this paper do not necessarily reflect those of the European Central Bank or the Eurosystem. Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2021.01580 .
An exploration of the emotional impact of working in an adult hospice service for Irish healthcare professionals
Authors: Sweeney Anne , Hynes Sinéad M 
Published: June 2024

Purpose: An ageing population and a global pandemic has placed greater demands on palliative care services. Numerous studies describe the patient experience in palliative care, however, few explore the healthcare professional’s experience of caring in this setting. This study explored the emotional challenges faced by palliative care professionals working in adult hospice services in Ireland. Design/methodology/approach: A narrative phenomenological approach was adopted, using interpretative phenomenological analysis to analyse results from five participants’ semi-structured interviews. Findings: The type of challenge experienced reflected the impact it had on the participant’s emotional wellbeing. Challenges perceived as achievable contributed to high levels of emotional wellbeing. These challenges often offered the opportunity for skill development and elicited positive feelings. Challenges perceived as uncontrollable negatively impacted the professional’s emotional wellbeing and increased their risk of burnout. Examples of this included the shift in service provision and professional expectations. The challenges palliative care professionals experience on a daily basis can negatively or positively impact their emotional wellbeing. Conclusion: Overall, this study highlighted challenges and their impacts experienced by palliative care professionals, illustrating key areas for improvement to prioritise staff wellbeing.
Evaluation of an end-of-life teaching programme for unregistered domiciliary care staff
Authors: Griffith Sue , Richmond Isabel , Harwood Melanie , Peckham Jenny 
Published: June 2024

Background: With increased focus on people being supported to die at home, and increased numbers of people predicted to die in the coming years in the UK, it is recognised that domiciliary carers need to be trained and supported to give end-of-life care. Recent reports suggest that this is not happening. Aim: To introduce and evaluate a training programme to upskill unregulated domiciliary care agency staff and integrate them into the palliative care teams, supporting registered nurses in caring for end-of-life patients. Method: A training course was devised and implemented. This report covers the first 3 years of running the course, and evaluates the difference that it made to the first 210 recipients’ ability and confidence in delivering end-of-life care, using a mixed-methods approach. Results: Pre- and post-course confidence questionnaires, evaluations, post-course testimonials, and managers’ comments all identified improvements in knowledge, skills and attitudes following training. Agency policies were re-written with up-to-date guidance on how to respond to death in the community. Conclusion: This article demonstrates that this model is effective in achieving its aims.
USE OF TAQMAN ARRAY TO INVESTIGATE INFECTION IN DIABETIC FOOT WOUNDS
Authors: Johnson-Lynn S. , Curran M. , Allen C. , Webber K. , Maes M. , Enoch D. , Robinson A.H. , Coll A.P. 
Published: June 2024

IntroductionDiabetic foot disease is a major public health problem with an annual NHS expenditure in excess of £1 billion. Infection increases risk of major amputation fivefold. Due to the polymicrobial nature of diabetic foot infections, it is often difficult to isolate the correct organism with conventional culture techniques, to deliver appropriate narrow spectrum antibiotics. Rapid DNA-based technology using multi-channel arrays presents a quicker alternative and has previously been used effectively in intensive care and respiratory medicine.MethodsWe gained institutional and Local Ethics Committee approval for a prospective cohort study of patients with clinically infected diabetic foot wounds. They all had deep tissue samples taken in clinic processed with conventional culture and real-time PCR TaqMan array.Results50 samples were taken from 39 patients between October 2020 and March 2022. 84% of patient were male, 88% had type 2 diabetes. The ulcers were of variable chronicity prior to sampling (range 1–113 weeks) and mean HbA1c was 67.2mmol/mol. Ulcers were on the heel (3), midfoot (6) and forefoot (41). Minimum follow up was 3 months. 6 ulcers healed, 24 patients were admitted due to foot disease, there were 2 major amputations and 4 deaths. TaqMan array results were available a mean of 4.3 days earlier than culture results. 9 patients had negative conventional cultures and 8 were negative onarray testing. 17 patients had the same organisms detected on culture and array. 16 of these 17 had additional organisms detected by array. The most frequent organisms detected on array that were not detected by culture were Staphylococcus spp., Enterobacter, Pseudomonas and fungi.ConclusionTaqMan array shows promise in detecting infecting organisms from diabetic foot wounds and providing earlier results than standard culture, which may enable appropriate and timely antibiotic therapy.
Steering abrupt autofocusing beams with metasurfaces [Invited]
Authors: Lin Rong , Yao Jin , Zhang Jingcheng , Che Xiaoyu , Leng Borui , Wang Zhihui , Chen Muku , Tsai Din Ping 
Published: June 2024

Abrupt autofocusing (AAF) beams, known for their non-diffractive
properties, extended focal depth, and self-healing capabilities, are
advantageous over conventional Gaussian beams in the biomedical field.
Compared to the previous
method that can only generate
a passive AAF beam, we introduce metasurfaces to achieve a dynamically
steered AAF beam at the incident wavelength of 532 nm. By rotating the
two metasurfaces in opposite directions of an angle
θ,
both the generated position of the AAF beam and the autofocusing
direction can be altered. Our theoretical analysis and full-wave
simulation results confirmed that the deflection angle of the AAF beam
can be finely adjusted from to 11°
without significantly affecting the focal length or focusing
efficiency. This capability allows for precision operation in
biomedical applications, including enhanced laser surgery, optical
tweezing, and optimized photodynamic therapy.
Ereignisvariable Tarife zur Lastverschiebung von steuerbaren Verbrauchseinrichtungen im Prosumer-Haushalt
Authors: Kübler Claudius , Essers Julien , Niehs Eike , Engel Bernd , Grandel Matthias 
Published: June 2024

ZusammenfassungDer Artikel beschreibt zunächst die aktuellen technischen und regulatorischen Rahmenbedingungen für Lastverschiebung im Prosumer-Haushalt. Seit Ende 2023 sind alle Rahmenbedingungen weitestgehend definiert, um in den nächsten Jahren automatisierte tarifbasierte Lastverschiebungen in den Markt einzuführen. Die vom Gesetzgeber geforderten flexiblen Tarife als Anreiz zur Lastverschiebung werden näher analysiert. Ein besonderer Fokus liegt dabei auf dynamischen Tarifen, bei denen die Vertriebspreise dynamisch an die Marktergebnisse der Strombörse gekoppelt werden. Auf Basis einer Marktübersicht und der Ergebnisse einer qualitativen Expertenbefragung von 12 Stadtwerken und Lieferanten erfolgt eine Bewertung dynamischer Tarife. Es wird ein alternatives Tarifkonzept auf Basis des Tarifanwendungsfalles 5 (ereignisvariabler Tarif) vorgestellt. Bei diesem Tarif werden drei bzw. vier Tarifstufen dynamisch an den Börsenpreis angepasst. Dieses Tarifkonzept ist datensparsamer und einfacher in den IT-Systemen umzusetzen als die notwendige Zählerstandsgangmessung (Tarifanwendungsfall 7) mit einem Messwert pro ¼ h bzw. h bei dynamischen Tarifen. Auch weist der ereignisvariable Tarif eine geringere Komplexität sowie ein geringeres Kostenrisiko für die Endverbraucher auf. Der Beitrag beschreibt die dafür notwendige Signalisierung zwischen dem Messstellenbetreiber (Gateway-Administrator), dem Smart Meter Gateway und einem Home Energy Management System zur automatischen Übermittlung der Tarifsignale. In einem quantitativen Vergleich auf Basis der Börsenstrompreise des Jahres 2023 werden verschiedene Ausgestaltungsvarianten des ereignisvariablen Tarifs mit einem dynamischen Tarif und einem Einheitspreistarif verglichen.
Ferroptosis-related gene MAPK3 is associated with the neurological outcome after cardiac arrest
Authors: Hou Hong xiang , Pang Li , Zhao Liang , Xing Jihong 
Published: June 2024

Background
Neuronal ferroptosis is closely related to the disease of the nervous system, and the objective of the present study was to recognize and verify the potential ferroptosis-related genes to forecast the neurological outcome after cardiac arrest.

Methods
Cardiac Arrest-related microarray datasets GSE29540 and GSE92696 were downloaded from GEO and batch normalization of the expression data was performed using “sva” of the R package. GSE29540 was analyzed to identify DEGs. Venn diagram was applied to recognize ferroptosis-related DEGs from the DEGs. Subsequently, The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were performed, and PPI network was applied to screen hub genes. Receiver operating characteristic (ROC) curves were adopted to determine the predictive value of the biomarkers, and the GSE92696 dataset was applied to further evaluate the diagnostic efficacy of the biomarkers. We explore transcription factors and miRNAs associated with hub genes. The “CIBERSORT” package of R was utilized to analyse the proportion infiltrating immune cells. Finally, validated by a series of experiments at the cellular level.

Results
112 overlapping ferroptosis-related DEGs were further obtained via intersecting these DEGs and ferroptosis-related genes. The GO and KEGG analysis demonstrate that ferroptosis-related DEGs are mainly involved in response to oxidative stress, ferroptosis, apoptosis, IL-17 signalling pathway, autophagy, toll-like receptor signalling pathway. The top 10 hub genes were selected, including HIF1A, MAPK3, PPARA, IL1B, PTGS2, RELA, TLR4, KEAP1, SREBF1, SIRT6. Only MAPK3 was upregulated in both GSE29540 and GAE92696. The AUC values of the MAPK3 are 0.654 and 0.850 in GSE29540 and GSE92696 respectively. The result of miRNAs associated with hub genes indicates that hsa-miR-214-3p and hsa-miR-483-5p can regulate the expression of MAPK3. MAPK3 was positively correlated with naive B cells, macrophages M0, activated dendritic cells and negatively correlated with activated CD4 memory T cells, CD8 T cells, and memory B cells. Compared to the OGD4/R24 group, the OGD4/R12 group had higher MAPK3 expression at both mRNA and protein levels and more severe ferroptosis.

Conclusion
In summary, the MAPK3 ferroptosis-related gene could be used as a biomarker to predict the neurological outcome after cardiac arrest. Potential biological pathways provide novel insights into the pathogenesis of cardiac arrest.
Completion and predictors of maternity continuum of care among women in the post-partum period in Gedeb district, southern Ethiopia: A community based cross-sectional study
Authors: Alemayehu Gemechu , Birhanu Simon , Alemayehu Afework , Mulatu Teshale 
Published: June 2024

Introduction
Maternal and neonatal complications related to pregnancy and childbirth pose a significant risk of morbidity and mortality to both the mother and the child. Despite its benefits in reducing maternal and neonatal mortality and morbidity associated with pregnancy and childbirth, the majority of Ethiopian mothers were dropped from the maternal continuum of care. Furthermore, there is a dearth of data regarding the status of the maternal continuum of care and its underlying factors in southern Ethiopia.

Objective
This study aimed to assess the completion of the maternity continuum of care and its predictors among postpartum women who had given birth in the previous six months in the Gedeb district of Gedio Zone, southern Ethiopia.

Methods
A community-based cross-sectional survey was conducted among 625 postpartum women selected by simple random sampling from June 1 to 30, 2022. The data was collected through face-to-face interviews using pretested, structured questionnaires. The association between the explanatory variables and the maternity continuum of care was examined using bivariate and multivariable logistic regression models. The adjusted odds ratio (AOR) with a 95% confidence interval was employed to measure the strength of association and the level of significance was set at p<0.05.

Results
In this study, only 32.00% (95% CI: 28.45, 35.77) of the women completed the maternal continuum of care. Attending primary education (AOR = 2.09; 95% CI: 1.23, 3.55), secondary and above education (AOR = 1.97; 95% CI: 1.01, 3.87), receiving counseling during ANC (AOR = 1.89; 95% CI: 1.22, 2.92), being well prepared for birth and complications readiness (AOR = 4.13; 95% CI: 2.23, 7.62), and having good knowledge of pregnancy danger signs (AOR = 4.13; 95% CI: 2.60, 6.55) were all significantly associated with completing the maternity continuum of care.

Conclusion
Nearly one-third of the women completed the maternity continuum of care. Enhancing women’s knowledge, offering counseling during prenatal visits, ensuring women’s awareness of pregnancy danger signs, and implementing health promotion programs targeted at enhancing birth preparedness and complications readiness for all are crucial.
Deprescribing interventions in older adults: An overview of systematic reviews
Authors: Chua Shiyun , Todd Adam , Reeve Emily , Smith Susan M. , Fox Julia , Elsisi Zizi , Hughes Stephen , Husband Andrew , Langford Aili , Merriman Niamh , Harris Jeffrey R. , Devine Beth , Gray Shelly L. ,   the Expert Panel
Published: June 2024

Objective
The growing deprescribing field is challenged by a lack of consensus around evidence and knowledge gaps. The objective of this overview of systematic reviews was to summarize the review evidence for deprescribing interventions in older adults.

Methods
11 databases were searched from 1st January 2005 to 16th March 2023 to identify systematic reviews. We summarized and synthesized the results in two steps. Step 1 summarized results reported by the included reviews (including meta-analyses). Step 2 involved a narrative synthesis of review results by outcome. Outcomes included medication-related outcomes (e.g., medication reduction, medication appropriateness) or twelve other outcomes (e.g., mortality, adverse events). We summarized outcomes according to subgroups (patient characteristics, intervention type and setting) when direct comparisons were available within the reviews. The quality of included reviews was assessed using A MeaSurement Tool to Assess systematic Reviews 2 (AMSTAR 2).

Results
We retrieved 3,228 unique citations and assessed 135 full-text articles for eligibility. Forty-eight reviews (encompassing 17 meta-analyses) were included. Thirty-one of the 48 reviews had a general deprescribing focus, 16 focused on specific medication classes or therapeutic categories and one included both. Twelve of 17 reviews meta-analyzed medication-related outcomes (33 outcomes: 25 favored the intervention, 7 found no difference, 1 favored the comparison). The narrative synthesis indicated that most interventions resulted in some evidence of medication reduction while for other outcomes we found primarily no evidence of an effect. Results were mixed for adverse events and few reviews reported adverse drug withdrawal events. Limited information was available for people with dementia, frailty and multimorbidity. All but one review scored low or critically low on quality assessment.

Conclusion
Deprescribing interventions likely resulted in medication reduction but evidence on other outcomes, in particular relating to adverse events, or in vulnerable subgroups or settings was limited. Future research should focus on designing studies powered to examine harms, patient-reported outcomes, and effects on vulnerable subgroups.

Systematic Review Registration
PROSPERO CRD42020178860.