bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of neutering on food intake, body weight and body composition in growing female kittens
Authors: Alexander Lucille G. , Salt Carina , Thomas Gaelle , Butterwick Richard 
Published: October 2011

To understand the effects of neutering on food intake, body weight (BW) and body composition in kittens, data from an unrelated study were subjected topost hocanalysis. A total of twelve pairs of 11-week-old female littermates were randomly assigned to either a neutered group (neutered at 19 weeks old) or an entire group (kept entire) and offered free access to a dry diet until the age of 1 year. Neutered kittens exhibited increased food intake and increased BW after neutering (bothP < 0·00 001). Food intake (per kg BW) peaked 10 weeks after neutering; the mean intake of neutered kittens was 17 (95 % CI 8, 27) % more than entire littermates (P = 0·00 014). The intake was then reduced until there was no significant difference between the groups 18 weeks post-neutering. By 52 weeks of age, the neutered kittens were 24 (95 % CI 11, 39) % heavier than entire littermates (P < 0·0001) with a body condition score (BCS) 16·6 (95 % CI 0·9, 34·8) % higher (P = 0·0028). Neutered kittens continued to grow significantly fatter after neutering (allP < 0·0014), while entire kittens showed no significant change after 18 weeks of age. As neutered kittens consumed similar amounts of energy to their entire littermates from 18 weeks post-neutering, while their BW, BCS and percentage fat continued to increase, we suggest that neutered kittens have a reduced metabolisable energy requirement, and should therefore be fed to maintain an ideal BCS rather thanad libitum.Moreover, to maintain an ideal BCS, entire kittens consumed 93 (95 % CI 87, 100) % of their theoretical intake at 26 weeks of age, and 79 (95 % CI 72, 87) % at 52 weeks of age, suggesting that the current energy recommendation is inappropriate for these kittens.
Intake of minerals, trace elements and vitamins in bone and raw food rations in adult dogs
Authors: Dillitzer Natalie , Becker Nicola , Kienzle Ellen 
Published: October 2011

The aim of the present study was to evaluate the vitamin and mineral content of bone and raw food rations fed to adult dogs in Germany. Pet owners completed a standardised feeding questionnaire. The composition of 95 rations was calculated from mean data for foodstuffs using nutrition balancing software. Typical ration ingredients were meats, fish, offal, dairy products, eggs, oil, nuts, cod liver oil and natural and commercial supplements. The supply of nutrients was compared with the recommended allowance (RA). Of the rations that were used, 10 % supplied < 25 % of the RA of Ca. In these rations, Ca:P was below 0·6:1, and vitamin D was below RA. About half of the rations supplied less iodine than the minimum requirement. Many of the rations had low Zn and Cu supply, and 25 % of the rations supplied only 70 % of RA for vitamin A or less. A total of 60 % of the rations had one or more of the above-mentioned imbalance. The remaining 40 % of rations either had minor problems like Ca excess from bones or they were balanced.
Lipid profile and insulin sensitivity in rats fed with high-fat or high-fructose diets
Authors: Zaman Muhammad-Quaid , Leray Véronique , Le Bloc'h Jérôme , Thorin Chantal , Ouguerram Khadija , Nguyen Patrick 
Published: October 2011

The occurrence and severity of obesity- and insulin resistance-related disorders vary according to the diet. The aim of the present longitudinal study was to examine the effects of a high-fat or a high-fructose diet on body weight (BW), body fat mass, insulin sensitivity (IS) and lipid profiles in a rat model of dietary-induced obesity and low IS. A total of eighteen, 12-week-old male Wistar rats were divided into three groups, and were fed with a control, a high-fat (65 % lipid energy) or a high-fructose diet (65 % fructose energy) for 10 weeks. BW, body fat mass (2H2O dilution method), IS (euglycaemic–hyperinsulinaemic clamp technique), plasma glucose, insulin, NEFA, TAG and total cholesterol were assessed before and at the end of 10-week period. Cholesterol was measured in plasma lipoproteins separated from pooled samples of each group and each time period by using fast-protein liquid chromatography. All rats had similar BW at the end of the 10-week period. Body fat mass was higher in the high-fat group compared to the control group. There was no change in basal glycaemia and insulinaemia. The IS was lower in the high-fat group and was unchanged in the high-fructose group, compared to the control group. Plasma TAG concentration and cholesterol distribution in lipoproteins did not change over time in any group. Plasma NEFA concentration decreased, whereas plasma TAG concentration increased over time, regardless of the diet in both cases. The 10-week high-fat diet led to obesity and low IS, whereas rats fed with the high-fructose diet exhibited no change in IS and lipidaemia. The high-fat diet had more deleterious response than high-fructose diet to induce obesity and low IS in rats.
Improvement of calcium balance byFructus Ligustri Lucidiextract in mature female rats was associated with the induction of serum parathyroid hormone levels
Authors: Dong Xiao-Li , Zhao Ming , Wong Kwun-Kit , Che Chun-Tao , Wong Man-Sau 
Published: October 2011

Fructus Ligustri Lucidi(FLL) is a commonly prescribed herb in many kidney-tonifying Traditional Chinese Medicinal formulae for the treatment of osteoporosis. The present study aimed to identify the active fractions in FLL and to characterise its effects on Ca balance, calciotropic hormone levels as well as bone properties in mature female rats fed diets containing different levels of Ca. In the present study, 4-month-old Sprague–Dawley female rats were treated with either FLL ethanol extract (EE), ethyl acetate-soluble fraction of EE (EAF), water-soluble fraction of EE (WF) or their vehicle for 12 weeks on a medium-Ca diet (MCD, 0·6 % Ca, 0·65 % P). Then, the Sprague–Dawley female rats treated with WF or its vehicle for 12 weeks were fed diets containing different levels of dietary Ca (low-Ca diet (LCD), 0·1 % Ca, 0·65 % P; MCD; high-Ca diet (HCD), 1·2 % Ca, 0·65 % P). The results demonstrated that WF from EE but not EAF exerted a prominent effect on Ca balance by inhibiting urinary and faecal Ca excretion. WF significantly increased Ca balance in rats fed MCD or HCD with an associated increase in serum parathyroid hormone (PTH) levels. WF did not alter bone mineral density or bone mineral content of the tibia in all the rats fed with different levels of dietary Ca. In conclusion, WF was responsible for the positive actions of FLL on Ca absorption and balance. The regulation of Ca balance by WF might involve its action in stimulating PTH production in the mature female rats.
Blueberry anthocyanins: protection against ageing and light-induced damage in retinal pigment epithelial cells
Authors: Liu Yixiang , Song Xue , Zhang Di , Zhou Feng , Wang Dan , Wei Ying , Gao Fengyi , Xie Liyang , Jia Gang , Wu Wei , Ji Baoping 
Published: October 2011

Retinal pigment epithelium (RPE) cells are vital for retinal health. However, they are susceptible to injury with ageing and exposure to excessive light, including UV (100–380 nm) and visible (380–760 nm) radiation. To evaluate the protective effect of blueberry anthocyanins on RPE cells,in vitrocell models of replicative senescent and light-induced damage were established in the present study. After purification and fractionation, blueberry anthocyanin extracts (BAE) were yielded with total anthocyanin contents of 31·0 (sd0·5) % and were used in this study. Replicative senescence of RPE cells was induced by repeatedly passaging cells from the fourth passage to the tenth. From the fifth passage, cultured RPE cells began to enter a replicative senescence, exhibiting reduced cell proliferation along with an increase in the number of β-galactosidase-positive cells. RPE cells maintained high cell viability (P < 0·01) and a low (P < 0·01) percentage of β-galactosidase-positive cells when treated with 0·1 μg/ml BAE. In contrast, after exposure to 2500 (sd500) lx light (420–800 nm) for 12 h, RPE cells in the positive control (light exposure, no BAE treatment) exhibited premature senescence, low (P < 0·01) cell viability and increased (P < 0·01) vascular endothelial growth factor (VEGF) release compared with negative control cells, which were not subjected to light irradiation and BAE exposure. Correspondingly, BAE is beneficial to RPE cells by protecting these cells against light-induced damage through the suppression of ageing and apoptosis as well as the down-regulation of the over-expressed VEGF to normal level. These results demonstrate that BAE is efficacious against senescence and light-induced damage of RPE cells.
The protein level of isoenergetic formulae does not modulate postprandial insulin secretion in piglets and has no consequences on later glucose tolerance
Authors: Blat Sophie , Morise Anne , Sauret Anne , Louveau Isabelle , Macé Katherine , Le Huërou-Luron Isabelle , Sève Bernard 
Published: October 2011

Early postnatal nutrition is involved in metabolic programming, an excess of protein being suspected to enhance early growth and the propensity to later develop insulin resistance and type 2 diabetes mellitus. The aim of the present study was to test the hypothesis that excessive protein intake during the suckling period would overstimulate the endocrine pancreas in the short term and alter durably its maturation, contributing to the later disruption of glucose homeostasis. Normal-birth-weight and low-birth-weight piglets were fed isoenergetic formulae providing an adequate-protein (AP, equivalent to sow milk) or a high-protein (HP, +48 %) supply between 7 and 28 d of age and were fed a standard diet until 70 d of age. During the formula-feeding period, the HP formula did not modify postprandial insulin secretion but transiently increased fasting insulin and the homeostasis model assessment-insulin resistance index (HOMA-IR, P < 0·05). Fasting insulin and HOMA-IR were restored to AP piglets' values 1 month after weaning. The structure of the endocrine pancreas was not affected by the protein content of the formula. The weight at birth had no major effect on the studied parameters. We concluded that a high-protein supply during the suckling period does not interfere with insulin secretion and endocrine pancreas maturation in the short term. It has no consequences either on glucose tolerance 1 month after weaning. The present study demonstrated that up-regulation of postprandial insulin secretion is not involved in higher growth observed in piglets fed a HP formula.
Including climate change in pest risk assessment: the peach fruit fly,Bactrocera zonata(Diptera: Tephritidae)
Authors: Ni W.L. , Li Z.H. , Chen H.J. , Wan F.H. , Qu W.W. , Zhang Z. , Kriticos D.J. 
Published: October 2011

AbstractBactrocera zonata(Saunders) is one of the most harmful species of Tephritidae. It causes extensive damage in Asia and threatens many countries located along or near the Mediterranean Sea. The climate mapping program, CLIMEX 3.0, and the GIS software, ArcGIS 9.3, were used to model the current and future potential geographical distribution ofB. zonata. The model predicts that, under current climatic conditions,B. zonatawill be able to establish itself throughout much of the tropics and subtropics, including some parts of the USA, southern China, southeastern Australia and northern New Zealand. Climate change scenarios for the 2070s indicate that the potential distribution ofB. zonatawill expand poleward into areas which are currently too cold. The main factors limiting the pest's range expansion are cold, hot and dry stress. The model's predictions of the numbers of generations produced annually byB. zonatawere consistent with values previously recorded for the pest's occurrence in Egypt. The ROC curve and the AUC (an AUC of 0.912) were obtained to evaluate the performance of the CLIMEX model in this study. The analysis of this information indicated a high degree of accuracy for the CLIMEX model. The significant increases in the potential distribution ofB. zonataprojected under the climate change scenarios considered in this study suggest that biosecurity authorities should consider the effects of climate change when undertaking pest risk assessments. To prevent the introduction and spread ofB. zonata, enhanced quarantine and monitoring measures should be implemented in areas that are projected to be suitable for the establishment of the pest under current and future climatic conditions.
Emergency and Escape: Explaining Derogations from Human Rights Treaties
Authors: Hafner-Burton Emilie M. , Helfer Laurence R. , Fariss Christopher J. 
Published: October 2011

AbstractSeveral prominent human rights treaties seek to minimize violations during emergencies by authorizing states to “derogate”—that is, to suspend certain civil and political liberties—in response to crises. The drafters of these treaties envisioned that international restrictions on derogations, together with international notification and monitoring mechanisms, would limit rights suspensions during emergencies. This article analyzes the behavior of derogating countries using new global data sets of derogations and states of emergency from 1976 to 2007. We argue that derogations are a rational response to domestic political uncertainty. They enable governments facing serious threats to buy time and legal breathing space from voters, courts, and interest groups to confront crises while signaling to these audiences that rights deviations are temporary and lawful. Our findings have implications for studies of treaty design and flexibility mechanisms, and compliance with international human rights agreements.
Testing Clausewitz: Nationalism, Mass Mobilization, and the Severity of War
Authors: Cederman Lars-Erik , Warren T. Camber , Sornette Didier 
Published: October 2011

AbstractDrawing on Clausewitz's classical theory, we argue that the emergence of mass nationalism following the French Revolution profoundly altered the nature of the units constituting the interstate system, thereby transforming the conduct of interstate warfare. To validate these assertions—and thus to test Clausewitz—we rely on quantitative evidence at the macro level, with a particular focus on the global distribution of interstate war sizes, measured in terms of battle deaths, over the past five centuries. Drawing on extreme value theory, we demonstrate that temporal discontinuities in the shapes of the tails of such distributions can be used to draw inferences about the nature of the mechanisms underlying the bloodiest events in world history. This approach allows us to show that the interstate system experienced a fundamental shift in the mechanisms underlying the production of war sizes: a shift that can be dated to the years 1770–1810, and that resulted in a systematic increase in war severity. These same tools also allow us to rule out a number of alternative explanations for this shift (including changes in population sizes and changes in weapons technology), while providing evidence for a specific account of war severity rooted in the mobilizational capacities of states.
Why Do Some Countries Get Better WTO Accession Terms Than Others?
Authors: Pelc Krzysztof J. 
Published: October 2011

AbstractThe process by which countries accede to the World Trade Organization (WTO) has become the subject of considerable debate. This article takes a closer look at what determines the concessions the institution requires of an entrant. In other words, who gets a good deal, and who does not? I argue that given the institutional design of accession proceedings and the resulting suspension of reciprocity, accession terms are driven by the domestic export interests of existing members. As a result, relatively greater liberalization will be imposed on those entrants that have more valuable market access to offer upon accession, something that appears to be in opposition to expectations during multilateral trade rounds, where market access functions as a bargaining chit. The empirical evidence supports these assertions. Looking at eighteen recent entrants at the six-digit product level, I find that controlling for a host of country-specific variables, as well as the applied protection rates on a given product prior to accession, the more a country has to offer, the more it is required to give. Moreover, I show how more democratic countries, in spite of their greater overall depth of integration, exhibit greater resistance to adjustment in key industries than do nondemocracies. Finally, I demonstrate that wealth exhibits a curvilinear effect. On the one hand, institutionalized norms lead members to exercise observable restraint vis-à-vis the poorest countries. On the other hand, the richest countries have the greatest bargaining expertise, and thus obtain better terms. The outcome, as I show using a semi-parametric analysis, is that middle-income countries end up with the most stringent terms, and have to make the greatest relative adjustments to their trade regimes.
The Long Arm of the Law: Extraterritoriality and the National Implementation of Foreign Bribery Legislation
Authors: Kaczmarek Sarah C. , Newman Abraham L. 
Published: October 2011

AbstractCan the application of domestic law by bureaucracies in powerful states alter policy dynamics globally? Courts and regulatory agencies with jurisdiction over large markets routinely impose national rules to conduct transpiring outside of their physical borders. Such extraterritoriality has expanded to issues ranging from antitrust to the environment. Proponents claim that extraterritorial acts can have far-reaching international consequences, spilling over into the domestic political economy of regulation in target states. Skeptics, however, question the effects of these sanctions against internationally mobile actors. In this study, we offer the first quantitative analysis of extraterritorial intervention for global policy convergence. In particular, we construct an original time-series panel data set to test the association between extraterritorial actions by U.S. prosecutors and the national enforcement of foreign bribery regulations in target countries. Our empirical analysis finds strong statistical evidence linking extraterritoriality to national policy implementation, with jurisdictions that experienced a U.S. intervention being twenty times more likely to enforce their national rules. The findings suggest the important influence that domestic law in powerful states may have for global cooperation in general and sheds light on the key pillars of international anticorruption efforts in particular.
Are laryngeal squamous cell carcinoma incidence and patient mortality a function of ABO blood grouping? A retrospective study
Authors: Adam S I , Wilson K M , Overholser S M , Khabbaz E , Moreno K , Patil Y J 
Published: October 2011

AbstractObjective:Few studies have examined the association between ABO blood grouping and head and neck cancer. This retrospective review examined the association between blood group and laryngeal cancer incidence and patient mortality.Methods:Of 271 patients treated for squamous cell laryngeal carcinoma (1997–2002), 143 patients with supraglottic, glottic and subglottic tumours were included; 128 patients were excluded. The blood group characteristics of patients and healthy blood donors were compared.Results:There was no significant correlation between blood type and laryngeal carcinoma incidence or mortality. Type A blood was commoner in African Americans with laryngeal cancer than Caucasian patients, but not significantly so. As expected, five-year survival rates were lower in patients with more advanced stage cancer (p < 0.0001).Conclusion:Although our findings show no association between blood group and five-year survival, these results are inconclusive, and warrant further study of the association between blood type and laryngeal (and other) head and neck cancers.
Human–carnivore conflict around Pendjari Biosphere Reserve, northern Benin
Authors: Sogbohossou Etotépé A. , de Iongh Hans H. , Sinsin Brice , de Snoo Geert R. , Funston Paul J. 
Published: October 2011

AbstractClose proximity between humans and large predators results in high levels of conflict. We investigated the extent of, and factors leading to, this conflict through focal group and individual interviews in all villages around Pendjari Biosphere Reserve, northern Benin. Livestock losses from 2000 to 2007 (n = 752) were reported to be mainly caused by spotted hyaena Crocuta crocuta (53.6%), baboon Papio anubis (24.8%), and lion Panthera leo (18.0%). These predators mainly predated sheep and goats (52.1%) and pigs (42.3%), with lions being the main predators of cattle (78.9%). Lion and hyaena diets were more diverse than that of baboons, which killed only small stock. The level of conflict increased during 2000–2007. Predation rate differs between predator species and is significantly influenced by month, rainfall of the month before the predation event, and length of the dry period in a year. The geographical position of the village, the distance of the village to the Park and the number of herbivores legally killed every hunting season also influenced predation intensity. Our findings suggest that improvement of husbandry techniques and education will reduce conflicts and contribute to improved conservation of these threatened predators.
A coupled configurational description of boundary shape based on distance and directionality
Authors: Shpuza Ermal 
Published: October 2011

AbstractA configurational method for describing shape is proposed based on two measures that gauge human experiences of moving through space: distance and changes in direction of travel. Boundary shapes from the built environment and nature are studied in a morphospace composed of two axes: one corresponding to each measure, to yield a typological classification of form. It is shown that the covariance between distance and directionality is mediated by the topological structure of embedded main circulation. Three kinds of circulation—elementary, ring, and linear—thus affect three fundamentally different balancing conditions between distance and directionality in boundary shapes. The analysis of large samples of shapes thus far demonstrates a “unique shape” status, where no two different shapes have the same pair of relative distance and directional fragmentation values.
Considering multiscale scenes to elucidate problems encumbering three-dimensional intellection and navigation
Authors: Glueck Michael , Khan Azam 
Published: October 2011

AbstractVirtual three-dimensional (3-D) environments have become pervasive tools in a number of professional and recreational tasks. However, interacting with these environments can be challenging for users, especially as these environments increase in complexity and scale. In this paper, we argue that the design of 3-D interaction techniques is an ill-defined problem. This claim is elucidated through the context of data-rich and geometrically complexmultiscale virtual 3-D environments, where unexpected factors can encumberintellectionandnavigation. We develop an abstract model to guide our discussion, which illustrates the cyclic relationship of understanding and navigating; a relationship that supports the iterative refinement of a consistent mental representation of the virtual environment. Finally, we highlight strategies to support the design of interactions in multiscale virtual environments, and propose general categories of research focus.