bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the Infrared Surface Emissivity Model (ISEM) with a Physical Emissivity Model
Authors: Hong Sungwook , Shin Inchul , Ou Mi-Lim 
Published: October 2009

Abstract
Accurate models of surface emissivity are important for interpreting satellite radiance observations. Surface emissivity depends on the satellite zenith angle, roughness, polarization, and refractive index of the surface. The effects of the roughness parameter on emissivity have not been studied thoroughly. By using an infrared geostationary satellite observation and a physical model based on the radiative transfer equation, the forward emissivity model and physical emissivity model are validated in the northwestern Pacific Ocean. First, the unpolarized emissivity at a given view angle and a wavelength of 10.8 μm in the thermal infrared spectral region is decomposed for the clear sky. The refractive index of the sea surface is quantitatively retrieved using the inversion of Fresnel equations. The refractive index of the sea surface derived from the physical emissivity exhibits a reasonable range within the infrared wavelength. The result of this investigation can be applied to the land emissivity model, which has not been studied thoroughly.
The Life Cycle of an Undular Bore and Its Interaction with a Shallow, Intense Cold Front
Authors: Hartung Daniel C. , Otkin Jason A. , Martin Jonathan E. , Turner David D. 
Published: October 2009

Abstract
The evolution of an undular bore and its associated wind shift, spawned by the passage of a shallow surface cold front over the Southern Great Plains of the United States, is examined using surface and remote sensing observations along with output from a high-resolution numerical model simulation. Observations show that a separation between the wind shift and thermodynamic properties of the front was induced by the formation of a bore over south-central Kansas around 0200 UTC 29 November 2006. By the time the front–bore complex passed through Lamont, Oklahoma, approximately 4 h later, the bore had reached its maximum intensity and its associated wind shift preceded the trailing baroclinic zone by 20 min. Within several hours the bore decayed and a cold frontal passage, characterized by a wind shift coincident with thermodynamic properties was observed at Okmulgee, Oklahoma. Thus, a substantial transformation in both the structural and dynamical characteristics of the bore as well as its relationship to the parent surface front occurred during a short period of time.
The details of this evolution are examined using output from a finescale numerical simulation, performed using the Weather Research and Forecasting (WRF) model. Analysis of the output reveals that as the bore advanced southeastward it moved into a region with a weaker surface stable layer. Consequently, the wave duct that had supported its maintenance steadily weakened resulting in dissipation of the bore. This circumstance led to a merger of the surface temperature and moisture boundaries with the orphaned wind shift, resulting in the cold frontal passage observed at Okmulgee.
A Quasi-Variational Algorithm for Nonlinear Normal-Mode Initialization
Authors: Bourchtein Andrei 
Published: October 2009

Abstract
Balance equations of normal-mode initialization are nonlinear time-independent partial differential equations solved by iterative methods. For the given geopotential, there are regions where these equations are not elliptic, which is reflected in the divergence of iterative algorithms. Variational approaches used to minimize the geopotential changes are more expensive than conventional methods. In this study a simple quasi-variational algorithm is proposed based on different forms of normal-mode initialization equations, which achieves a good balance of atmospheric fields and ensures small changes of geopotential analysis values.
Comparison of Ensemble Kalman Filters under Non-Gaussianity
Authors: Lei Jing , Bickel Peter , Snyder Chris 
Published: October 2009

Abstract
Recently various versions of ensemble Kalman filters (EnKFs) have been proposed and studied. This work concerns, in a mathematically rigorous manner, the relative performance of two major versions of EnKF when the forecast ensemble is non-Gaussian. The approach is based on the stability of the filtering methods against small model violations, using the expected squared L2 distance as a measure of the deviation between the updated distributions. Analytical and experimental results suggest that both stochastic and deterministic EnKFs are sensitive to the violation of the Gaussian assumption, while the stochastic filter is relatively more stable than the deterministic filter under certain circumstances, especially when there are wild outliers. These results not only agree with previous empirical studies, but also suggest a natural choice of a free parameter in the square root Kalman filter algorithm.
Nocturnal Tornado Climatology*
Authors: Kis Amanda K. , Straka Jerry M. 
Published: October 2009

Abstract
Very few studies on nocturnal tornadoes have been performed, and operational forecasting of nocturnal tornadoes is often guided by the results of studies that are biased toward daytime tornadoes. However, it is likely that tornado environments vary significantly over the diurnal cycle. For example, the depth and nature of storm inflow may change as the daytime boundary layer transitions into a stable nighttime boundary layer, and a low-level jet (LLJ) may form above in the residual layer and free atmosphere. The study performed herein is used to investigate features unique to nocturnal boundary layers and the free atmosphere above that may affect nocturnal tornadoes.
A climatology of significant (F2–F5) nocturnal tornadoes in the contiguous United States between 2004 and 2006 shows that environments deemed by previous climatologies as unfavorable for late afternoon/early evening tornadogenesis are in fact conducive to significant nocturnal tornadogenesis. These nocturnal environments may be characterized by marginal convective instability with shallow stable boundary layers. Substantial low-level shear, storm relative helicity (SREH), and exceptionally strong nocturnal low-level jets stand out as the most common features of significant nocturnal tornadoes and have utility in distinguishing environments of weak nocturnal tornadoes from environments of significant nocturnal tornadoes. Analysis of the data gathered in the climatology shows that the suggestions of existing tornado climatologies are inadequate and even misguiding for forecasting nocturnal tornadoes. Several recommendations for operational forecasting of nocturnal tornadoes are made based on the results of this climatology.
Application of Spatial Verification Methods to Idealized and NWP-Gridded Precipitation Forecasts
Authors: Ahijevych David , Gilleland Eric , Brown Barbara G. , Ebert Elizabeth E. 
Published: October 2009

Abstract
Several spatial forecast verification methods have been developed that are suited for high-resolution precipitation forecasts. They can account for the spatial coherence of precipitation and give credit to a forecast that does not necessarily match the observation at any particular grid point. The methods were grouped into four broad categories (neighborhood, scale separation, features based, and field deformation) for the Spatial Forecast Verification Methods Intercomparison Project (ICP). Participants were asked to apply their new methods to a set of artificial geometric and perturbed forecasts with prescribed errors, and a set of real forecasts of convective precipitation on a 4-km grid. This paper describes the intercomparison test cases, summarizes results from the geometric cases, and presents subjective scores and traditional scores from the real cases.
All the new methods could detect bias error, and the features-based and field deformation methods were also able to diagnose displacement errors of precipitation features. The best approach for capturing errors in aspect ratio was field deformation. When comparing model forecasts with real cases, the traditional verification scores did not agree with the subjective assessment of the forecasts.
Nilotinib for the frontline treatment of Ph+ chronic myeloid leukemia
Authors: Rosti Gianantonio , Palandri Francesca , Castagnetti Fausto , Breccia Massimo , Levato Luciano , Gugliotta Gabriele , Capucci Adele , Cedrone Michele , Fava Carmen , Intermesoli Tamara , Cambrin Giovanna Rege , Stagno Fabio , Tiribelli Mario , Amabile Marilina , Luatti Simona , Poerio Angela , Soverini Simona , Testoni Nicoletta , Martinelli Giovanni , Alimena Giuliana , Pane Fabrizio , Saglio Giuseppe , Baccarani Michele ,   for the GIMEMA CML Working Party
Published: October 2009

AbstractNilotinib has a higher binding affinity and selectivity for BCR-ABL with respect to imatinib and is an effective treatment of chronic myeloid leukemia (CML) after imatinib failure. In a phase 2 study, 73 early chronic-phase, untreated, Ph+ CML patients, received nilotinib at a dose of 400 mg twice daily. The primary endpoint was the complete cytogenetic response (CCgR) rate at 1 year. With a median follow-up of 15 months, the CCgR rate at 1 year was 96%, and the major molecular response rate 85%. Responses were rapid, with 78% CCgR and 52% major molecular response at 3 months. During the first year, the treatment was interrupted at least once in 38 patients (52%). The mean daily dose ranged between 600 and 800 mg in 74% of patients, 400 and 599 mg in 18% of patients, and was less than 400 mg in 8% of patients. Dose interruptions were mainly due to nonhematologic and biochemical side effects. Myelosuppression was irrelevant. One patient progressed to blastic crisis after 6 months; one went off-treatment for lipase increase grade 4 (no pancreatitis). Nilotinib is safe and very active in early chronic-phase CML. These data support a role for nilotinib for the frontline treatment of CML. This study was registered at ClinicalTrials.gov as NCT00481052.
Kisspeptin Signaling in the Brain
Authors: Oakley Amy E. , Clifton Donald K. , Steiner Robert A. 
Published: October 2009

Abstract
Kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged as key players in the regulation of reproduction. Mutations in humans or genetically targeted deletions in mice of either Kiss1 or Kiss1r cause profound hypogonadotropic hypogonadism. Neurons that express Kiss1/kisspeptin are found in discrete nuclei in the hypothalamus, as well as other brain regions in many vertebrates, and their distribution, regulation, and function varies widely across species. Kisspeptin neurons directly innervate and stimulate GnRH neurons, which are the final common pathway through which the brain regulates reproduction. Kisspeptin neurons are sexually differentiated with respect to cell number and transcriptional activity in certain brain nuclei, and some kisspeptin neurons express other cotransmitters, including dynorphin and neurokinin B (whose physiological significance is unknown). Kisspeptin neurons express the estrogen receptor and the androgen receptor, and these cells are direct targets for the action of gonadal steroids in both male and female animals. Kisspeptin signaling in the brain has been implicated in mediating the negative feedback action of sex steroids on gonadotropin secretion, generating the preovulatory GnRH/LH surge, triggering and guiding the tempo of sexual maturation at puberty, controlling seasonal reproduction, and restraining reproductive activity during lactation. Kisspeptin signaling may also serve diverse functions outside of the classical realm of reproductive neuroendocrinology, including the regulation of metastasis in certain cancers, vascular dynamics, placental physiology, and perhaps even higher-order brain function.
The Mammalian Ovary from Genesis to Revelation
Authors: Edson Mark A. , Nagaraja Ankur K. , Matzuk Martin M. 
Published: October 2009

AbstractTwo major functions of the mammalian ovary are the production of germ cells (oocytes), which allow continuation of the species, and the generation of bioactive molecules, primarily steroids (mainly estrogens and progestins) and peptide growth factors, which are critical for ovarian function, regulation of the hypothalamic-pituitary-ovarian axis, and development of secondary sex characteristics. The female germline is created during embryogenesis when the precursors of primordial germ cells differentiate from somatic lineages of the embryo and take a unique route to reach the urogenital ridge. This undifferentiated gonad will differentiate along a female pathway, and the newly formed oocytes will proliferate and subsequently enter meiosis. At this point, the oocyte has two alternative fates: die, a common destiny of millions of oocytes, or be fertilized, a fate of at most approximately 100 oocytes, depending on the species. At every step from germline development and ovary formation to oogenesis and ovarian development and differentiation, there are coordinated interactions of hundreds of proteins and small RNAs. These studies have helped reproductive biologists to understand not only the normal functioning of the ovary but also the pathophysiology and genetics of diseases such as infertility and ovarian cancer. Over the last two decades, parallel progress has been made in the assisted reproductive technology clinic including better hormonal preparations, prenatal genetic testing, and optimal oocyte and embryo analysis and cryopreservation. Clearly, we have learned much about the mammalian ovary and manipulating its most important cargo, the oocyte, since the birth of Louise Brown over 30 yr ago.
Androgen receptor disruption increases the osteogenic response to mechanical loading in male mice
Authors: Callewaert Filip , Bakker Astrid , Schrooten Jan , Meerbeek Bart Van , Verhoeven Guido , Boonen Steven , Vanderschueren Dirk 
Published: October 2009

Abstract
In female mice, estrogen receptor-alpha (ERα) mediates the anabolic response of bone to mechanical loading. Whether ERα plays a similar role in the male skeleton and to what extent androgens and androgen receptor (AR) affect this response in males remain unaddressed. Therefore, we studied the adaptive response of in vivo ulna loading in AR-ERα knockout (KO) mice and corresponding male and female single KO and wild-type (WT) littermates using dynamic histomorphometry and immunohistochemistry. Additionally, cultured bone cells from WT and AR KO mice were subjected to mechanical loading by pulsating fluid flow in the presence or absence of testosterone. In contrast with female mice, ERα inactivation in male mice had no effect on the response to loading. Interestingly, loading induced significantly more periosteal bone formation in AR KO (+320%) and AR-ERα KO mice (+256%) compared with male WT mice (+114%) and had a stronger inhibitory effect on SOST/sclerostin expression in AR KO versus WT mice. In accordance, the fluid flow-induced nitric oxide production was higher in the absence of testosterone in bone cells from WT but not AR KO mice. In conclusion, AR but not ERα activation limits the osteogenic response to loading in male mice possibly via an effect on WNT signaling. © 2010 American Society for Bone and Mineral Research
Ferritin ferroxidase activity: A potent inhibitor of osteogenesis
Authors: Zarjou Abolfazl , Jeney Viktória , Arosio Paolo , Poli Maura , Zavaczki Erzsébet , Balla György , Balla József 
Published: October 2009

Abstract
Hemochromatosis is a known cause of osteoporosis, and iron overload has deleterious effects on bone. Although iron overload and its association with osteoporosis has long been recognized, the pathogenesis and exact role of iron have been undefined. Bone is an active tissue with constant remodeling capacity. Osteoblast (OB) development and maturation are under the influence of core binding factor α-1 (CBF-α1), which induces expression of OB-specific genes, including alkaline phosphatase, an important enzyme in early osteogenesis, and osteocalcin, a noncollagenous protein deposited within the osteoid. This study investigates the mechanism by which iron inhibits human OB activity, which in vivo may lead to decreased mineralization, osteopenia, and osteoporosis. We demonstrate that iron-provoked inhibition of OB activity is mediated by ferritin and its ferroxidase activity. We confirm this notion by using purified ferritin H-chain and ceruloplasmin, both known to possess ferroxidase activity that inhibited calcification, whereas a site-directed mutant of ferritin H-chain lacking ferroxidase activity failed to provide any inhibition. Furthermore, we are reporting that such suppression is not restricted to inhibition of calcification, but OB-specific genes such as alkaline phosphatase, osteocalcin, and CBF-α1 are all downregulated by ferritin in a dose-responsive manner. This study corroborates that iron decreases mineralization and demonstrates that this suppression is provided by iron-induced upregulation of ferritin. In addition, we conclude that inhibition of OB activity, mineralization, and specific gene expression is attributed to the ferroxidase activity of ferritin. © 2010 American Society for Bone and Mineral Research
Abdominal aortic calcification on vertebral morphometry images predicts incident myocardial infarction
Authors: Bolland Mark J , Wang Tom KM , van Pelt Niels C , Horne Anne M , Mason Barbara H , Ames Ruth W , Grey Andrew B , Ruygrok Peter N , Gamble Greg D , Reid Ian R 
Published: October 2009

Abstract
Abdominal aortic calcification (AAC) measured on spine X-rays is an established risk factor for cardiovascular disease. We investigated whether AAC assessed using vertebral morphometry and a recently developed scoring system (AAC-8) is reliable and associated with cardiovascular risk factors or events. A total of 1471 healthy postmenopausal women and 323 healthy middle-aged and older men participated in 5 and 2 year trials of calcium supplements, respectively. AAC-8 was assessed on vertebral morphometry images at baseline and follow-up. In addition, 163 men also had coronary artery calcification measured using computed tomography. Cardiovascular events during the trials were independently adjudicated. We found strong inter- and intrameasurer agreement for AAC-8 (κ &gt; 0.87). The prevalence of AAC increased with age (p &lt; .01) in women and in men. AAC was associated with many established cardiovascular risk factors, with serum calcium in women (p = .002) and with higher coronary calcium scores in men (p = .03). Estimated 5 year cardiovascular risk increased with increasing AAC-8 score (p &lt; .001) in women and in men. The presence of AAC independently predicted myocardial infarction (MI) in women [hazards ratio (HR) = 2.30, p = .007] and men (HR = 5.32, p = .04), even after adjustment for estimated cardiovascular risk in women. In women, AAC independently predicted cardiovascular events (MI, stroke, or sudden death) (HR = 1.74, p = .007), and changes in AAC-8 score over time were associated with MI and cardiovascular events, even after adjustment for estimated cardiovascular risk. In summary, scoring AAC on vertebral morphometric scans is a reproducible method of assessing cardiovascular risk that independently predicts incident MI and cardiovascular events, even after taking into account traditional cardiovascular risk factors. © 2010 American Society for Bone and Mineral Research
The relationship between fractures and DXA measures of BMD in the distal femur of children and adolescents with cerebral palsy or muscular dystrophy
Authors: Henderson Richard C , Berglund Lisa M , May Ryan , Zemel Babette S , Grossberg Richard I , Johnson Julie , Plotkin Horacio , Stevenson Richard D , Szalay Elizabeth , Wong Brenda , Kecskemethy Heidi H , Harcke H Theodore 
Published: October 2009

Abstract
Children with limited or no ability to ambulate frequently sustain fragility fractures. Joint contractures, scoliosis, hip dysplasia, and metallic implants often prevent reliable measures of bone mineral density (BMD) in the proximal femur and lumbar spine, where BMD is commonly measured. Further, the relevance of lumbar spine BMD to fracture risk in this population is questionable. In an effort to obtain bone density measures that are both technically feasible and clinically relevant, a technique was developed involving dual-energy X-ray absorptiometry (DXA) measures of the distal femur projected in the lateral plane. The purpose of this study is to test the hypothesis that these new measures of BMD correlate with fractures in children with limited or no ability to ambulate. The relationship between distal femur BMD Z-scores and fracture history was assessed in a cross-sectional study of 619 children aged 6 to 18 years with muscular dystrophy or moderate to severe cerebral palsy compiled from eight centers. There was a strong correlation between fracture history and BMD Z-scores in the distal femur; 35% to 42% of those with BMD Z-scores less than −5 had fractured compared with 13% to 15% of those with BMD Z-scores greater than −1. Risk ratios were 1.06 to 1.15 (95% confidence interval 1.04–1.22), meaning a 6% to 15% increased risk of fracture with each 1.0 decrease in BMD Z-score. In clinical practice, DXA measure of BMD in the distal femur is the technique of choice for the assessment of children with impaired mobility. © 2010 American Society for Bone and Mineral Research
Estrogen augments shear stress–induced signaling and gene expression in osteoblast-like cells via estrogen receptor–mediated expression of β1-integrin
Authors: Yeh Chiuan-Ren , Chiu Jeng-Jiann , Lee Chih-I , Lee Pei-Ling , Shih Yu-Tsung , Sun Jui-Sheng , Chien Shu , Cheng Cheng-Kung 
Published: October 2009

Abstract
Estrogen and mechanical forces are positive regulators for osteoblast proliferation and bone formation. We investigated the synergistic effect of estrogen and flow-induced shear stress on signal transduction and gene expression in human osetoblast-like MG63 cells and primary osteoblasts (HOBs) using activations of extracellular signal-regulated kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) and expressions of c-fos and cyclooxygenase-2 (I) as readouts. Estrogen (17β-estradiol, 10 nM) and shear stress (12 dyn/cm2) alone induced transient phosphorylations of ERK and p38 MAPK in MG63 cells. Pretreating MG63 cells with 17β-estradiol for 6 hours before shearing augmented these shear-induced MAPK phosphorylations. Western blot and flow cytometric analyses showed that treating MG63 cells with 17β-estradiol for 6 hrs induced their β1-integrin expression. This estrogen-induction of β1-integrin was inhibited by pretreating the cells with a specific antagonist of estrogen receptor ICI 182,780. Both 17β-estradiol and shear stress alone induced c-fos and Cox-2 gene expressions in MG63 cells. Pretreating MG63 cells with 17β-estradiol for 6 hrs augmented the shear-induced c-fos and Cox-2 expressions. The augmented effects of 17β-estradiol on shear-induced MAPK phosphorylations and c-fos and Cox-2 expressions were inhibited by pretreating the cells with ICI 182,780 or transfecting the cells with β1-specific small interfering RNA. Similar results on the augmented effect of estrogen on shear-induced signaling and gene expression were obtained with HOBs. Our findings provide insights into the mechanism by which estrogen augments shear stress responsiveness of signal transduction and gene expression in bone cells via estrogen receptor–mediated increases in β1-integrin expression. © 2010 American Society for Bone and Mineral Research