bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Longevinex (modified resveratrol) on cardioprotection and its mechanisms of action
Authors: Mukherjee Subhendu , Ray Diptarka , Lekli Istvan , Bak Istvan , Tosaki Arpad , Das Dipak K. 
Published: November 2010

Although resveratrol has been proven to possess diverse health benefits, several recent reports have demonstrated conflicting results on some aspects of its effects, including its anti-aging properties. Considerable debate appears to exist on the dose and bioavailability of resveratrol, leading to the controversies on its effectiveness. To resolve the problem, we designed a study with a resveratrol formulation that contained resveratrol supplemented with 5% quercetin and 5% rice bran phytate (commercially known as Longevinex). These ingredients were micronized to increase the bioavailability. Sprague–Dawley rats were gavaged with either Longevinex or vehicle (5% quercetin plus 5% rice bran phytate), and rats were sacrificed after 1 or 3 months, when isolated working hearts were subjected to 30 min ischemia followed by 2 h of reperfusion. Longevinex-treated hearts, irrespective of the duration of treatments, revealed superior cardiac performance, reduced infarct size, and induction of survival signals as evidenced by increased Bcl2/Bax ratio and enhanced Akt phosphorylation. In contrast, LC3-II and Beclin were enhanced significantly after 3 months of Longevinex treatment, suggesting that autophagy occurred only after feeding Longevinex to rats for a prolonged period of time. Corroborating with the results of autophagy, Sirt1 and Sirt3 increased significantly only after 3 months of Longevinex treatment, suggesting that enhanced expression of Sirts correlated with induction of autophagy. In concert, Longevinex caused phosphorylation and nuclear translocation of FoxO1, FoxO3a, and FoxO4, indicating involvement of FoxOs with autophagy. Since Sirts and FoxOs are reliable markers of longevity, the results appear to suggest that Longevinex induces longevity after prolonged feeding via induction of autophagy, while it converts death signals into survival signals and provides cardioprotection within a relatively shorter period of time.
Ipomoea obscura ameliorates cyclophosphamide-induced toxicity by modulating the immune system and levels of proinflammatory cytokine and GSH
Authors: Hamsa T. P. , Kuttan Girija 
Published: November 2010

Ipomoea obscura L. is a widely used medicinal plant. The objective of this study was to investigate its protective activity against cyclophosphamide (CTX)-induced toxicity in mouse models. Swiss albino mice were treated intraperitoneally with CTX (25 mg/kg body weight) along with I. obscura extract (10 mg/kg body weight) for 10 days. Extract significantly reduced myelosuppression caused by CTX and improved the relative organ weight, total white blood cell count, and bone marrow cellularity. The elevated levels of parameters related to pathophysiology of the liver, namely glutamate pyruvate transaminase, alkaline phosphatase, and lipid peroxidation, were significantly reduced by extract treatment. Reduction of liver and intestinal glutathione levels of CTX-treated animals was reversed by I. obscura. The lowered levels of cytokines, namely IFN-γ, IL-2, and granulocyte–monocyte colony-stimulating factor after CTX treatment were found to be increased in I. obscura treated animals. Treatment with I. obscura could also decrease the level of proinflammatory cytokine TNF-α. The data suggested that I. obscura can act as a potent chemoprotective agent and can be used as an adjuvant in chemotherapeutic applications.
Habitat use by female western roe deer (Capreolus capreolus): influence of resource availability on habitat selection in two contrasting years
Authors: Pellerin M. , Calenge C. , Saïd S. , Gaillard J.- M. , Fritz H. , Duncan P. , Van Laere G. 
Published: November 2010

In most previous studies of habitat selection, the use of a given habitat type is assumed to be directly proportional to its availability. However, the use and (or) the selection of a given habitat may be conditional on the availability of that habitat. We aim here to (i) identify the environmental variables involved in habitat selection, (ii) identify classes of individuals with similar patterns of habitat selection, and (iii) assess whether habitat use changes with changing availability of habitat types, within monthly home ranges of female western roe deer ( Capreolus capreolus (L., 1758)). We found that some females adjust their habitat use according to the distribution of resources within habitats. Females with similar home ranges in terms of resource quantity and quality showed similar patterns of habitat selection. Differences in habitat use between 2 years with contrasting resource availability showed that temporal changes of environmental conditions influenced the pattern of habitat selection by female roe deer. Habitat selection also differed between periods of the life cycle likely because of contrasted energy requirements. This study shows that the relationship between habitat use by herbivores and habitat availability is nonproportional, and that the availability of resources influences use mostly at intermediate values.
A distance-based analysis of habitat selection by American black bears (Ursus americanus) on the Bruce Peninsula, Ontario, Canada
Authors: Obbard Martyn E. , Coady Melissa B. , Pond Bruce A. , Schaefer James A. , Burrows Frank G. 
Published: November 2010

Because of their wide-ranging habits, conserving large carnivores such as American black bears ( Ursus americanus Pallas, 1780) often depends on understanding habitat needs beyond the boundary of protected areas. We studied habitat selection by black bears in the vicinity of Bruce Peninsula National Park, Ontario — a small, isolated population whose persistence appears dependent on habitat on lands outside the Park. We used an approach based on Euclidean distances to document seasonal habitat selection at two spatial scales and to identify candidate habitat types for protection. Adult females selected dense mixed forests to establish home ranges within the population range, whereas subadults and yearlings selected dense deciduous forests. Within home ranges, adults selected dense mixed forest in spring–summer and dense deciduous forest in late summer – fall. Subadults selected dense deciduous forest, marsh, dense mixed forest, and water during the spring–summer and avoided developed lands and roads. Yearlings selected dense mixed forest, dense deciduous forest, and sparse forests in spring–summer and dense deciduous forest and dense mixed forest in late summer – fall. The selection of dense deciduous and dense mixed forest stands, especially at the broader scale, suggests that strategies to ensure persistence of this isolated population should focus on protecting the integrity of these stands.
Thermal environments of overwintering Eastern Box Turtles (Terrapene carolina carolina)
Authors: Savva Yulia , Swarth Christopher W. , Gupchup Jayant , Szlavecz Katalin 
Published: November 2010

Using a mixed-effects model for 21 Eastern Box Turtles ( Terrapene carolina carolina (L., 1758)) over three winters in Maryland, USA, we demonstrate that overwintering-site temperature was mainly related to air temperature. After controlling for air temperature, between-year variation accounted for 7%, between-turtle variation accounted for 3%, and variation owing to age class accounted for 1% of the total variation in overwintering-site temperature. Turtles showed overwintering-site fidelity and the location of overwintering sites did not depend on sex or age. According to the developed function, air temperature would have to increase by 3 °C over the overwintering period to raise the temperature of overwintering sites by about 1 °C, assuming no changes in other environmental factors; this level of warming is not expected until 2070–2090 according to general climate circulation models.
‘What’s Teleology Got To Do With It?’ A Reinterpretation of Aristotle’s Generation of Animals V
Authors: Gotthelf Allan , Leunissen Mariska 
Published: November 2010

AbstractDespite the renewed interest in Aristotle’s Generation of Animals in recent years, the subject matter of GA V, its preferred mode(s) of explanation, and its place in the treatise as a whole remain misunderstood. Scholars focus on GA I-IV, which explain animal generation in terms of efficient-final causation, but dismiss GA V as a mere appendix, thinking it to concern (a) individual, accidental differences among animals, which are (b) purely materially necessitated, and (c) are only tangentially related to the topics discussed in the earlier books. In this paper, we defend an alternative and more integrated account of GA V by closely examining Aristotle’s methodological introduction in GA V.1 778a16-b19 and his teleological explanation of the differences of teeth in GA V.8. We argue for the unity of both GA V and of GA as a whole and present a more nuanced theory of teleological explanation in Aristotle’s biology.
At Play in the Field of Possibles
Authors: Zaner Richard M. 
Published: November 2010

AbstractThis essay focuses on questions central to Husserl’s essential methodology, specifically his notion of ‘free-fantasy variation,’ which he regarded as his ‘fundamental methodological insight.’ At the heart of this ‘vital element of phenomenology’ is what he often terms ‘as-if experience’ thanks to which anything whatever (actual or possible) can be considered either for its own sake or as an example of something else. Further analysis explores the act of exemplification, the act of feigning (termed possibilizing) and the shifts of attention and orientation that ground free-fantasy variation. Exemplification and possibilizing are then examined in daily life to discern what makes the complex act of feigning at all possible. An examination of the phenomenon of upsets (of what is typically expected) brings the core sense of possibilizing to light. A focus on the dramatic force intrinsic to these experiences, and the essential place of reflective awareness inherent to them, makes apparent how the rudimentary sense of self begins to emerge, and there follows an analysis of this self-referentiality of possibilizing. The analysis then concludes with a brief examination of Husserl’s so-called ‘zig-zag’ method of constitutive phenomenology.
Heidegger’s Nietzsche, the Doctrine of Eternal Return, and the Phenomenology of Human Finitude
Authors: Stolorow Robert D. 
Published: November 2010

AbstractNietzsche’s doctrine of the eternal return of the same, seen through the lens of Heidegger’s interpretation, captures the groundlessness of existence in a technological world devoid of normative significance. The author contends that the temporality depicted poetically in the thought of eternal return is the traumatic temporality of human finitude, to which Nietzsche was exposed at the age of 4 when the death of his father shattered his world. Nietzsche’s metaphysical position is seen as a metaphorical window into the phenomenology of finitude and of the struggle to overcome it.
Orthopraxy in Tannaitic Literature
Authors: Grossberg David M. 
Published: November 2010

AbstractM. Sanhedrin 10:1 is well-known as a succinct statement of rabbinic doctrine. Yet as a statement of doctrine, this mishnah’s language is remarkably pragmatic: it proscribes saying certain things but does not explicitly proscribe believing them. I propose that this use of practical rather than doctrinal phraseology was an intentional editorial stance of the Mishnah’s compilers. A close philological examination of parallel texts in the Tosefta and Seder Olam reveals that earlier generations of the textual tradition underlying this mishnah phrased these same prohibitions using doctrinal terms such as “denying” or “not acknowledging.” Moreover, this choice of pragmatic language is evident throughout the Mishnah, even when fundamentals of Judaic faith such as belief in one God and in the oral Torah are being addressed. The Mishnah’s compilers, perhaps in response to trends like early Christian antinomianism and heresiology, chose to produce a work dedicated to orthopraxy rather than orthodoxy.
The Title Ethnarch in Second Temple Period Judea
Authors: Sharon Nadav 
Published: November 2010

AbstractThe title Ethnarch appears in Second Temple sources in reference to four Judean rulers: Simon the Hasmonean, John Hyrcanus, Hyrcanus II, and Archelaus, son of Herod. This evidence is usually taken for granted. However, a meticulous analysis of the sources shows that we should not rely on the evidence pertaining to the early Hasmoneans (Simon and John Hyrcanus), and it rather seems that the title was first employed only by the Romans (probably Julius Caesar) for Hyrcanus II. The paper further asserts that this title exemplifies a unique perception of the Jewish people by the Romans. Additionally, the paper notes some ramifications that this understanding of the title Ethnarch and the view which it exemplifies may have on certain issues of the Second Temple period.<xref ref-type="fn" rid="FN0">*</xref>
The Limitations on Critical Thinking on Religious Issues under Article 20 of ICCPR and its Relation to Freedom of Expression
Authors: Eltayeb Mohamed Saeed M. 
Published: November 2010

AbstractThis article aims at examining the admissible scope of limitations on critical thinking on religious issues and the circumstances under which criticism of a religion may fall within the scope of Article 20 of the ICCPR. What does this imply in relation to freedom of expression, in particular artistic freedom? To what extent does the promotion of freedom of expression require States to punish advocacy of religious hatred which constitutes incitement to discrimination, hostility or violence? The main premise of the article is that the questions mentioned above should be seen in terms of the balance and complementarity of competing rights, namely, the right to freedom of religion and respect for human dignity of believers vis-à-vis the right to freedom of expression. This balance cannot invariably be set for all places, but should instead be maintained taking into account the historical experiences and local conditions. Furthermore, the article argues that the right to freedom of expression is not absolute and that international human rights law affirms certain restrictions on exercising this right. The question, however, of where to draw the boundaries between the right to freedom of expression and advocacy of religious hatred that constitutes incitement to discrimination, hostility or violence can best be answered contextually and with due regard to, inter alia, local conditions, history, culture and political tensions.
Limits to the Restrictions to Freedom of Expression—Criteria and Application
Authors: Schmidt Mogens 
Published: November 2010

AbstractThe freedoms of opinion and of expression constitute the cornerstone of any democratic society and form a solid and fundamental basis for development. Without an open space for the marketplace of ideas to flourish, societies fail to progress by any measure on the human, social, and economic development scale. Given the paramount importance of this fundamental right, restrictions on freedom of expression, in order to be permissible, must be narrowly defined and will have to be derived from the relevant international legal standards. In this context it is equally important to note that there is no a priori hierarchy of rights.
Arthroscopic Treatment of Osteochondral Lesions of the Ankle With Matrix-Associated Chondrocyte Implantation
Authors: Aurich Matthias , Bedi Harvinder S. , Smith Peter J. , Rolauffs Bernd , Mückley Thomas , Clayton James , Blackney Mark 
Published: November 2010

Background: Conventional autologous chondrocyte transplantation in the ankle often requires tibial or fibular osteotomies with potential morbidity for the patient. Advances in biotechnology and surgical techniques have resulted in the development of matrix-associated chondrocyte implantation (MACI). As the chondrocyte-loaded scaffold can be applied arthroscopically, this procedure is especially useful for the treatment of osteochondral defects in the ankle. Hypothesis: Arthroscopic MACI is a safe procedure in the ankle with good clinical and magnetic resonance imaging results. Study Design: Case series; Level of evidence, 4. Methods: The authors reviewed all patients (n = 18) who had arthroscopic MACI for osteochondral lesions of the ankle (n = 19) between February 2006 and May 2008 clinically and with magnetic resonance imaging. The pain and disability module of the Foot Function Index (FFI), the American Orthopaedic Foot & Ankle Society (AOFAS) clinical rating system, the Core Scale of the Foot and Ankle Module of the American Academy of Orthopaedic Surgeons (AAOS) Lower Limb Outcomes Assessment Instruments, and the Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score were used. The clinical results up to 3 years after MACI (mean follow-up, 24.5 months) were compared with preoperative data for 14 cases and the magnetic resonance imaging data for all 19. Results: A significant improvement (50.3% ± 13.2%) in all clinical scores was noted (FFI pain before MACI: 5.5 ± 2.0, after MACI: 2.8 ± 2.2; FFI disability before MACI: 5.0 ± 2.3, after MACI: 2.6 ± 2.2; AOFAS before MACI: 58.6 ± 16.1, after MACI: 80.4 ± 14.1; AAOS standardized mean before MACI: 59.9 ± 16.0, after MACI: 83.5 ± 13.2; AAOS normative score before MACI: 23.0 ± 13.0, after MACI: 42.2 ± 10.7). According to the AOFAS Hindfoot score, 64% were rated as excellent and good, whereas 36% were rated fair and poor. The results correlated with the age of the patient and the duration of symptoms, but not with the size of the lesion. Sixteen patients (89%) reported regular sports activities before the onset of symptoms; 13 of them (81%) returned to sports after the MACI, 56% (n = 9) to the same level. The mean MOCART score was 62.4 ± 15.8 points. In general, there was no relation between MOCART score and clinical outcome, although the filling of the defect showed some correlation with the AAOS score. Conclusion: Arthroscopic MACI is a safe procedure for the treatment of osteochondral lesions in the ankle with overall good clinical and magnetic resonance imaging results.
Impact of early transcranial Doppler screening and intensive therapy on cerebral vasculopathy outcome in a newborn sickle cell anemia cohort
Authors: Bernaudin Françoise , Verlhac Suzanne , Arnaud Cécile , Kamdem Annie , Chevret Sylvie , Hau Isabelle , Coïc Lena , Leveillé Emmanuella , Lemarchand Elisabeth , Lesprit Emmanuelle , Abadie Isabelle , Medejel Nadia , Madhi Fouad , Lemerle Sophie , Biscardi Sandra , Bardakdjian Josiane , Galactéros Frédéric , Torres Martine , Kuentz Mathieu , Ferry Christelle , Socié Gérard , Reinert Philippe , Delacourt Christophe 
Published: November 2010

AbstractTranscranial Doppler (TCD) is used to detect children with sickle cell anemia (SCA) who are at risk for stroke, and transfusion programs significantly reduce stroke risk in patients with abnormal TCD. We describe the predictive factors and outcomes of cerebral vasculopathy in the Créteil newborn SCA cohort (n = 217 SS/Sβ0), who were early and yearly screened with TCD since 1992. Magnetic resonance imaging/magnetic resonance angiography was performed every 2 years after age 5 (or earlier in case of abnormal TCD). A transfusion program was recommended to patients with abnormal TCD and/or stenoses, hydroxyurea to symptomatic patients in absence of macrovasculopathy, and stem cell transplantation to those with human leukocyte antigen-genoidentical donor. Mean follow-up was 7.7 years (1609 patient-years). The cumulative risks by age 18 years were 1.9% (95% confidence interval [95% CI] 0.6%-5.9%) for overt stroke, 29.6% (95% CI 22.8%-38%) for abnormal TCD, which reached a plateau at age 9, whereas they were 22.6% (95% CI 15.0%-33.2%) for stenosis and 37.1% (95% CI 26.3%-50.7%) for silent stroke by age 14. Cumulating all events (stroke, abnormal TCD, stenoses, silent strokes), the cerebral risk by age 14 was 49.9% (95% CI 40.5%-59.3%); the independent predictive factors for cerebral risk were baseline reticulocytes count (hazard ratio 1.003/L × 109/L increase, 95% CI 1.000-1.006; P = .04) and lactate dehydrogenase level (hazard ratio 2.78/1 IU/mL increase, 95% CI1.33-5.81; P = .007). Thus, early TCD screening and intensification therapy allowed the reduction of stroke-risk by age 18 from the previously reported 11% to 1.9%. In contrast, the 50% cumulative cerebral risk suggests the need for more preventive intervention.
The hemostatic status of pediatric recipients of adult liver grafts suggests that plasma levels of hemostatic proteins are not regulated by the liver
Authors: Lisman Ton , Platto Marco , Meijers Joost C. M. , Haagsma Elizabeth B. , Colledan Michele , Porte Robert J. 
Published: November 2010

Abstract
Plasma levels of coagulation factors differ profoundly between adults and children, but are remarkably stable throughout adulthood. It is unknown which factors determine plasma levels of coagulation factors in a given individual. We hypothesized that the liver, which synthesizes coagulation factors, also controls plasma levels. We measured a panel of coagulation factors in samples taken from either adults or young children who underwent a liver transplantation with adult donor livers. Samples were taken 1-3 months after transplantation, when the patients were clinically stable with adequate graft function. After liver transplantation, the hemostatic profile of the pediatric group was remarkably different from that of the adult group, and resembled the hemostatic profile of normal children. Thus, children transplanted with an adult liver graft maintain a pediatric hemostatic profile after transplantation despite receiving an adult liver graft. These findings suggest that plasma levels of hemostatic proteins are not controlled by the liver.
Genetics of fetal hemoglobin in Tanzanian and British patients with sickle cell anemia
Authors: Makani Julie , Menzel Stephan , Nkya Siana , Cox Sharon E. , Drasar Emma , Soka Deogratius , Komba Albert N. , Mgaya Josephine , Rooks Helen , Vasavda Nisha , Fegan Gregory , Newton Charles R. , Farrall Martin , Lay Thein Swee 
Published: November 2010

AbstractFetal hemoglobin (HbF, α2γ2) is a major contributor to the remarkable phenotypic heterogeneity of sickle cell anemia (SCA). Genetic variation at 3 principal loci (HBB cluster on chromosome 11p, HBS1L-MYB region on chromosome 6q, and BCL11A on chromosome 2p) have been shown to influence HbF levels and disease severity in β-thalassemia and SCA. Previous studies in SCA, however, have been restricted to populations from the African diaspora, which include multiple genealogies. We have investigated the influence of these 3 loci on HbF levels in sickle cell patients from Tanzania and in a small group of African British sickle patients. All 3 loci have a significant impact on the trait in both patient groups. The results suggest the presence of HBS1L-MYB variants affecting HbF in patients who are not tracked well by European-derived markers, such as rs9399137. Additional loci may be identified through independent genome-wide association studies in African populations.