bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and molecular features of mucosa‐associated lymphoid tissue (MALT) lymphomas of salivary glands
Authors: Toso Andrea , Aluffi Paolo , Capello Daniela , Conconi Annarita , Gaidano Gianluca , Pia Francesco 
Published: April 2009

AbstractBackground.To analyze clinical features and to discuss the modality of investigation and treatment of a series of mucosa‐associated lymphoid tissue (MALT) lymphomas. To investigate the prevalence of aberrant promoter methylation, responsible for gene inactivation, in a selected panel of genes potentially involved in the pathogenesis of B‐cell malignancies as O6‐methylguanine‐DNA methyltransferase (MGMT), p73, death‐associated protein kinase (DAP‐k).Methods.Nine patients with primary MALT lymphoma of the salivary glands were retrospectively reviewed. MGMT, p73, DAP‐k apoptotic pathways were tested.Results.Methylation of DAP‐k was common (5/8; 63%). Histological examination ensured diagnostic confirmation, whereas fine‐needle aspiration cytology was not definitively diagnostic.Conclusion.Histological assessment is the gold standard in the diagnosis of salivary gland lesions. Parotidectomy represents a safe and reliable diagnostic tool leading to a definite diagnosis of MALT lymphomas in all cases and curative without other treatment in early‐stage MALT lymphoma. © 2009 Wiley Periodicals, Inc. Head Neck, 2009
Genetic polymorphisms in the tobacco smoke carcinogens detoxifying enzyme UGT1A7 and the risk of head and neck cancer
Authors: Lacko Martin , Roelofs Hennie M. J. , te Morsche Rene H. M. , Voogd Adri C. , Ophuis Michael B. Oude , Peters Wilbert H. M. , Manni Johannes J. 
Published: April 2009

AbstractBackground.UGT1A7 is an enzyme involved in the metabolism of (pre)carcinogens present in tobacco smoke. We investigated whether genetic polymorphisms inUGT1A7, with predicted altered enzyme activity, may have a risk‐modifying effect on head and neck carcinogenesis.Methods.Blood samples from 427 patients with oral, pharyngeal, and laryngeal carcinoma and 420 healthy control subjects were investigated forUGT1A7polymorphisms. Based on these polymorphisms, patients and controls were divided according to predicted enzyme activity (low, intermediate, high).Results.Logistic regression analysis showed a significant increased distribution of predicted high activity UGT1A7 polymorphisms among the patients (OR:1.44; 95% CI: 1.07–1.93). Stratified analyses demonstrated that high activity UGT1A7 polymorphisms were even more significantly present in patients with laryngeal cancer, older patients, heavy smokers, and heavy drinkers when compared with the control subjects.Conclusions.Predicted high activity UGT1A7 polymorphisms were significantly associated with an increased risk of head and neck cancer. © 2009 Wiley Periodicals, Inc. Head Neck, 2009
Endoscopic nasopharyngectomy with potassium‐titanyl‐phosphate (KTP) laser for early locally recurrent nasopharyngeal carcinoma
Authors: Ko Jenq‐Yuh , Wang Cheng‐Ping , Ting Lai‐Lei , Yang Tsung‐Lin , Tan Ching‐Ting 
Published: April 2009

AbstractBackground.Although early recurrent nasopharyngeal carcinoma (NPC) can be treated with surgery alone, conventional nasopharyngectomy still results in serious complications. Endoscopic nasopharyngectomy has been introduced, but data on the treatment outcomes of this technique are lacking.Methods.From March 2004 to December 2007, 28 patients with rT1 or rT2a NPC underwent potassium‐titanyl‐phosphate (KTP) laser nasopharyngectomy by endoscopic techniques with curative intent.Results.Twenty‐five patients underwent surgery alone. Only 3 patients received postoperative adjuvant therapy. The 2‐year local disease‐free and 2‐year overall survival rates for the 12 patients with rT1 tumor and for the 16 patients with rT2a tumor were 100% and 41.7% (p = .007); and 90.9% and 38.5% (p = .03), respectively. Only 3 patients had obvious osteonecrosis at the nasopharynx, and 1 patient developed hypoglossal nerve dysfuction.Conclusions.Endoscopic KTP laser nasopharyngectomy is a simple, safe, and successful procedure for treating rT1 NPC, though its benefits are less clear for rT2a. © 2009 Wiley Periodicals, Inc. Head Neck, 2009
Sequential egocentric strategy is acquired as early as allocentric strategy: Parallel acquisition of these two navigation strategies
Authors: Iglói Kinga , Zaoui Mohamed , Berthoz Alain , Rondi‐Reig Laure 
Published: April 2009

AbstractAt least two main cognitive strategies can be used to solve a complex navigation task: the allocentric or map‐based strategy and the sequential egocentric or route‐based strategy. The sequential egocentric strategy differs from a succession of independent simple egocentric responses as it requires a sequential ordering of events, possibly sharing functional similarity with episodic memory in this regard. To question the possible simultaneous encoding of sequential egocentric and allocentric strategies, we developed a paradigm in which these two strategies are spontaneously used or imposed. Our results evidenced that sequential egocentric strategy can be spontaneously acquired at the onset of the training as well as allocentric strategy. Allocentric and sequential egocentric strategies could be used together within a trial, and bidirectional shifts (between trials) were spontaneously performed during the training period by 30% of the participants. Regardless of the strategy used spontaneously during the training, all participants could execute immediate shifts to the opposite non previously used strategy when this strategy was imposed. Altogether, our findings suggest that subjects acquire different types of spatial knowledge in parallel, namely knowledge permitting allocentric navigation as well as knowledge permitting sequential egocentric navigation. © 2009 Wiley‐Liss, Inc.
Enhanced spatial memory and hippocampal long‐term potentiation in p75 neurotrophin receptor knockout mice
Authors: Barrett Graham L. , Reid Christopher A. , Tsafoulis Christina , Zhu Wenmei , Williams David A. , Paolini Antonio G. , Trieu Jennifer , Murphy Mark 
Published: April 2009

AbstractPrevious reports have described increases in the size and number of cholinergic neurons in the basal forebrain in p75 neurotrophin receptor (p75NTR) knockout mice. In an earlier study, we also found improved spatial memory in these mice, raising the possibility that p75NTR regulates hippocampal function by its effects on the cholinergic basal forebrain. We therefore investigated hippocampal long‐term potentiation in p75NTR knockout mice that shared the same genetic background as control 129/Sv mice. We also investigated heterozygous mice, carrying just one functional p75NTR allele. The p75NTR knockout mice had enhanced long‐term potentiation in the Schafer collateral fiber synapses of the hippocampus. Heterozygous mice had an intermediate level, greater than controls but less than knockout mice. Hippocampal choline acetyltransferase activity was also markedly elevated in p75NTR knockout mice, with a smaller increase in heterozygous mice. In the Barnes maze, p75NTR knockout mice displayed markedly superior learning to controls, and this was evident over the three age brackets tested. At each age, the performance of heterozygous mice was intermediate to the other groups. In the open field test, p75NTR knockout mice exhibited greater stress‐related behavioral responses, including freezing, than did control animals. There were no differences between the three groups in a test of olfactory function. The dose‐dependent effects of p75NTR gene copy number on hippocampal plasticity and spatial memory indicate that p75NTR has profound effects on hippocampal function. Bearing in mind that p75NTR is very sparsely expressed in the adult hippocampus and has a potent effect on hippocampal choline acetyltransferase activity, the effects of p75NTR on hippocampal function are likely to be mediated indirectly, by its actions on basal forebrain cholinergic neurons. © 2009 Wiley‐Liss, Inc.
The application of integrated urban inundation model in Republic of Korea
Authors: Kang Sang‐Hyeok 
Published: April 2009

AbstractIn urban areas with a high building density, features such as roads, buildings and river dykes significantly affect flow dynamics and flood propagation. This should therefore be accounted for in the model set‐up. While 2D hydraulic models of densely urban areas are at the forefront of current research into flood inundation mechanisms, these models are constrained by inadequate parameters of topography and insufficient data. In order to solve these problems, topographic information obtained from digital elevation model (DEM) is directly programmed into the urban inundation model for a densely urban area, without exchanging the input data. In this paper, the extraction of building area is described using a tight coupling approach within a GIS environment, and its influence on the extent of flood inundation with a high building density is estimated. Copyright © 2009 John Wiley & Sons, Ltd.
Analysis of the mechanical behavior of a titanium scaffold with a repeating unit‐cell substructure
Authors: Ryan Garrett , McGarry Patrick , Pandit Abhay , Apatsidis Dimitrios 
Published: April 2009

AbstractTitanium scaffolds with controlled microarchitecture have been developed for load bearing orthopedic applications. The controlled microarchitecture refers to a repeating array of unit‐cells, composed of sintered titanium powder, which make up the scaffold structure. The objective of this current research was to characterize the mechanical performance of three scaffolds with increasing porosity, using finite element analysis (FEA) and to compare the results with experimental data. Scaffolds were scanned using microcomputed tomography and FEA models were generated from the resulting computer models. Macroscale and unit‐cell models of the scaffolds were created. The material properties of the sintered titanium powders were first evaluated in mechanical tests and the data used in the FEA. The macroscale and unit‐cell FEA models proved to be a good predictor of Young's modulus and yield strength. Although macroscale models showed similar failure patterns and an expected trend in UCS, strain at UCS did not compare well with experimental data. Since a rapid prototyping method was used to create the scaffolds, the original CAD geometries of the scaffold were also evaluated using FEA but they did not reflect the mechanical properties of the physical scaffolds. This indicates that at present, determining the actual geometry of the scaffold through computed tomography imaging is important. Finally, a fatigue analysis was performed on the scaffold to simulate the loading conditions it would experience as a spinal interbody fusion device. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 2009
Biomimetic sealant based on gelatin and microbial transglutaminase: An initial in vivo investigation
Authors: Liu Yi , Kopelman Doron , Wu Li‐Qun , Hijji Karam , Attar Ishay , Preiss‐Bloom Orahn , Payne Gregory F. 
Published: April 2009

AbstractThe potential of an in situ gel‐forming adhesive was examined as a hemostatic surgical sealant. The gel‐forming mechanism for this adhesive mimics the last stages of blood coagulation but uses nonblood proteins. Specifically, gelatin is used as the structural protein and a calcium‐independent microbial transglutaminase (mTG) is used as the crosslinking enzyme. In vitro burst pressure tests with porcine skin demonstrate that the gelatin‐mTG adhesive forms a gel within 30 min under moist conditions and this gel can restrain pressures of 200 mmHg. In vivo tests with a rat liver wound model showed that the gelatin‐mTG adhesive achieves complete hemostasis in 2.5 min and the gel (i.e., the biomimetic clot) offers substantial adhesive and cohesive strength. Complete hemostasis was also observed in 2.5 min after the gelatin‐mTG adhesive was applied to a briskly bleeding rat femoral artery wound. In a large animal porcine model, a femoral artery wound that resulted in extensive bleeding was sealed in 4 min by (i) clamping the artery for temporary hemostasis, (ii) removing excess blood, and (iii) applying the gelatin‐mTG adhesive. Thus, the biomimetic gelatin‐mTG adhesive may provide a simple, safe, and cost‐effective surgical sealant. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 2009
Lamination for subdermal implant fixation
Authors: Hori Bryan D. , Petrell Royann J. , Trites Andrew W. , Godbey Tamara 
Published: April 2009

AbstractThirty‐six aluminum oxide laminated discs were implanted into 12 young rabbits (18 with a 0.5‐mm porous layer and 18 with 1 mm) to determine whether implants that are porous only on one side could fixate to subcutaneous tissue. After 3 months, discs were encased within thin pouches (0.02–0.14 mm) of fibrous connective tissue, as would have been expected of a completely porous implant. Solid sides showed no, while the porous sides showed little, attachment to pouches. Forty‐seven percentage (17) of the discs had moved 1.4 ± 0.8 cm beyond the 4.7 + 1 cm they had moved due to normal skin growth, while two others had moved between 6.2 and 6.5 cm beyond this measure. The proportion of 1 mm porous layer discs migrating within subcutaneous tissue was no greater than the proportion of 0.5 mm layer discs migrating (p = 0.15). Porous layer height and disc migration did not affect the attachment strength of pouch to surrounding tissues (68 ± 23 N, p = 0.34). Pouch thickness, which has been associated to the level of applied forces in other studies, increased with migration distance (p = 0.054). Results indicate that one‐sided porous discs are likely easier to retrieve than completely porous ones, but cannot be prevented from migrating in loose tissue of young animals. Data is being used to design subdermal radio frequency devices for endangered marine animals. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 2009
Paying attention in tough times
Authors: Reider Rob 
Published: April 2009

AbstractTypically, the major concern for business owners and management is generating sales and increasing the bottom line. But in tough economic times like today, they must pay more attention to daily operations. They must look at all organizational functions and activities that help—or hinder—the effort to stay economical, efficient, and effective. The author leads us through a valuable operations checklist to help your company prosper in this difficult economic climate. © 2009 Wiley Periodicals, Inc.
Can the attorney‐client and work‐product privileges survive the annual audit?
Authors: Sonnier Blaise M. , Lassar Sharon S. 
Published: April 2009

AbstractThe IRS has been aggressively pursuing tax accrual workpapers in court. If the IRS prevails, corporate executives who rely on the legal advice of attorneys in making decisions may be providing litigation road maps to those who sue their companies.This potential exposure of tax accrual workpapers is a wake‐up call for executives. They must review their procedures for seeking and securing legal advice. The authors reveal the vital steps management must take to protect privileged documents. © 2009 Wiley Periodicals, Inc.
Auditor risk with mortgage‐backed M&As
Authors: Metcalf Lance B. , Liner Bryne J. 
Published: April 2009

AbstractAll professional service advisors have experienced the devastating impact of the credit crisis upon the economy. But auditors are particularly affected—especially by merger‐and‐acquisition (M&A) transactions for targets with mortgage‐backed securities. The authors discuss the current M&A environment for these transactions, look at auditors' risks, and examine possible solutions. © 2009 Wiley Periodicals, Inc.
How will valuation changes affect M&A deals?
Authors: Woodlock Peter , Peng Gang 
Published: April 2009

AbstractIn late 2007 and early 2008, both the Financial Accounting Standards Board and the International Accounting Standards Board issued separate statements on business combinations. There are a number of similarities between the two new standards, but differences do exist that could lead to dramatically different valuations of assets and liabilities in a merger‐and‐acquisition (M&A) deal. Deal makers must understand the differences in the two standards to decide how to structure any new deal. The authors take an in‐depth look at the issues involved. © 2009 Wiley Periodicals, Inc.
Resource consumption accounting: Manager‐focused management accounting
Authors: White Larry 
Published: April 2009

AbstractThis article presents resource consumption accounting (RCA), a management accounting methodology that focuses on the manager—not the external financial statement—as the primary user of its information. Based largely on German management accounting methods in use for at least 60 years, it incorporates the best insights of activity‐based costing (ABC), the theory of constraints (TOC), and traditional management accounting thinking. © 2009 Wiley Periodicals, Inc.
Cluster expansion models for flexible‐backbone protein energetics
Authors: Apgar James R. , Hahn Seungsoo , Grigoryan Gevorg , Keating Amy E. 
Published: April 2009

AbstractProtein structure prediction and design often involve discrete modeling of side‐chain conformations on structural templates. Introducing backbone flexibility into such models has proven important in many different applications. Backbone flexibility improves model accuracy and provides access to larger sequence spaces in computational design, although at a cost in complexity and time. Here, we show that the influence of backbone flexibility on protein conformational energetics can be treated implicitly, at the level of sequence, using the technique of cluster expansion. Cluster expansion provides a way to convert structure‐based energies into functions of sequence alone. It leads to dramatic speed‐ups in energy evaluation and provides a convenient functional form for the analysis and optimization of sequence‐structure relationships. We show that it can be applied effectively to flexible‐backbone structural models using four proteins: α‐helical coiled‐coil dimers and trimers, zinc fingers, and Bcl‐xL/peptide complexes. For each of these, low errors for the sequence‐based models when compared with structure‐based evaluations show that this new way of treating backbone flexibility has considerable promise, particularly for protein design. © 2009 Wiley Periodicals, Inc. J Comput Chem, 2009
Computation of determinant expansion coefficients within the graphically contracted function method
Authors: Gidofalvi Gergely , Shepard Ron 
Published: April 2009

AbstractMost electronic structure methods express the wavefunction as an expansion of N‐electron basis functions that are chosen to be either Slater determinants or configuration state functions. Although the expansion coefficient of a single determinant may be readily computed from configuration state function coefficients for small wavefunction expansions, traditional algorithms are impractical for systems with a large number of electrons and spatial orbitals. In this work, we describe an efficient algorithm for the evaluation of a single determinant expansion coefficient for wavefunctions expanded as a linear combination of graphically contracted functions. Each graphically contracted function has significant multiconfigurational character and depends on a relatively small number of variational parameters called arc factors. Because the graphically contracted function approach expresses the configuration state function coefficients as products of arc factors, a determinant expansion coefficient may be computed recursively more efficiently than with traditional configuration interaction methods. Although the cost of computing determinant coefficients scales exponentially with the number of spatial orbitals for traditional methods, the algorithm presented here exploits two levels of recursion and scales polynomially with system size. Hence, as demonstrated through applications to systems with hundreds of electrons and orbitals, it may readily be applied to very large systems. © 2009 Wiley Periodicals, Inc. J Comput Chem, 2009
The effect of the sixth sulfur ligand in the catalytic mechanism of periplasmic nitrate reductase
Authors: Cerqueira N. M. F. S. A. , Gonzalez P. J. , Brondino C. D. , Romão M. J. , Romão C. C. , Moura I. , Moura J. J. G. 
Published: April 2009

AbstractThe catalytic mechanism of nitrate reduction by periplasmic nitrate reductases has been investigated using theoretical and computational means. We have found that the nitrate molecule binds to the active site with the Mo ion in the +6 oxidation state. Electron transfer to the active site occurs only in the proton‐electron transfer stage, where the MoV species plays an important role in catalysis. The presence of the sulfur atom in the molybdenum coordination sphere creates a pseudo‐dithiolene ligand that protects it from any direct attack from the solvent. Upon the nitrate binding there is a conformational rearrangement of this ring that allows the direct contact of the nitrate with MoVI ion. This rearrangement is stabilized by the conserved methionines Met141 and Met308. The reduction of nitrate into nitrite occurs in the second step of the mechanism where the two dimethyl‐dithiolene ligands have a key role in spreading the excess of negative charge near the Mo atom to make it available for the chemical reaction. The reaction involves the oxidation of the sulfur atoms and not of the molybdenum as previously suggested. The mechanism involves a molybdenum and sulfur‐based redox chemistry instead of the currently accepted redox chemistry based only on the Mo ion. The second part of the mechanism involves two protonation steps that are promoted by the presence of MoV species. MoVI intermediates might also be present in this stage depending on the availability of protons and electrons. Once the water molecule is generated only the MoVI species allow water molecule dissociation, and, the concomitant enzymatic turnover. © 2009 Wiley Periodicals, Inc. J Comput Chem, 2009
CCL5 secreted by senescent aged fibroblasts induces proliferation of prostate epithelial cells and expression of genes that modulate angiogenesis
Authors: Eyman D. , Damodarasamy M. , Plymate S.R. , Reed M.J. 
Published: April 2009

AbstractThere is increased interest in the effects of secretory products from aged cells on promoting both benign and malignant cell growth. We identified a human fibroblast line, AG04382, from an aged donor that naturally demonstrated senescence‐associated features and whose conditioned media significantly induced proliferation of benign prostatic hyperplasia (BPH1) cells. Candidate cytokines mediating this effect were identified with protein arrays and validated by ELISA. We found that the AG04382 fibroblast line secreted high levels of CXCL5, CCL5, and CCL2, but relative to the other lines, its conditioned media was unique in its increased expression of CCL5. Blocking studies using specific antibodies against CXCL5, CCL5, and CCL2 in the conditioned media of AG04382 showed that only CCL5 contributed significantly to BPH1 proliferation. Stimulation of BPH1 cells with rhuCCL5 resulted in increased proliferation and migration, as well as significant changes in the expression of genes that influence angiogenesis. These data suggest that CCL5 is a candidate chemokine secreted by aged cells that promotes prostate growth and regulates angiogenesis. J. Cell. Physiol. 220: 376–381, 2009. © 2009 Wiley‐Liss, Inc.