bluuebunny/crossref_metadata_2025_split huggingface dataset:
In-depth simulation of rainfall–runoff relationships using machine learning methods
Authors: Fuladipanah Mehdi , Shahhosseini Alireza , Rathnayake Namal , Azamathulla Hazi Md. , Rathnayake Upaka , Meddage D. P. P. , Tota-Maharaj Kiran 
Published: June 2024

ABSTRACT
Measurement inaccuracies and the absence of precise parameters value in conceptual and analytical models pose challenges in simulating the rainfall–runoff modeling (RRM). Accurate prediction of water resources, especially in water scarcity conditions, plays a distinctive and pivotal role in decision-making within water resource management. The significance of machine learning models (MLMs) has become pronounced in addressing these issues. In this context, the forthcoming research endeavors to model the RRM utilizing four MLMs: Support Vector Machine, Gene Expression Programming (GEP), Multilayer Perceptron, and Multivariate Adaptive Regression Splines (MARS). The simulation was conducted within the Malwathu Oya watershed, employing a dataset comprising 4,765 daily observations spanning from July 18, 2005, to September 30, 2018, gathered from rainfall stations, and Kappachichiya hydrometric station. Of all input combinations, the model incorporating the input parameters Qt−1, Qt−2, and R̄t was identified as the optimal configuration among the considered alternatives. The models' performance was assessed through root mean square error (RMSE), mean average error (MAE), coefficient of determination (R2), and developed discrepancy ratio (DDR). The GEP model emerged as the superior choice, with corresponding index values (RMSE, MAE, R2, DDRmax) of (43.028, 9.991, 0.909, 0.736) during the training process and (40.561, 10.565, 0.832, 1.038) during the testing process.
Remediation potential of arsenic in the alluvial aquifers in the Bengal Basin: insights from simulations and time estimates
Authors: Chen Xinyi 
Published: June 2024

ABSTRACT
Arsenic is found in significant quantities within the alluvial aquifers. Bangladesh heavily relies on the alluvial aquifers of the Bengal Basin as a source of irrigation and drinking water. Due to the flat topography, arsenic within an aquifer is not easily flushed out of the system. Additionally, continuous, unregulated pumping causes arsenic from deeper aquifers to migrate to shallower levels. This study simulates groundwater and contaminant transport in the alluvial aquifers of the Bengal Basin by comparison between two scenarios prior to human intervention with different sea levels, employing a combination of MODFLOW, MODPATH and MT3DMS. The simulations demonstrate that the hydraulic gradient and flow rates were higher during periods of considerably lower sea levels than they are at present. Additionally, it would require 5,600 years for the Holocene aquifer and 3,300 years for the Last Glacial Period aquifer to flush arsenic to the Bangladesh standard concentrations in drinking water in a 100-m-thick contaminated aquifer. This implies that if the sea level continues to rise with climate change, it will be difficult to remove arsenic from the alluvial aquifers in the Bengal Basin by natural flushing, which means artificial interventions need to be done for the interest of nation's health.
Embracing epistemic uncertainty: a risk evaluation method for pollutants in stormwater
Authors: Pons Vincent , Strømberg Merethe , Blecken Godecke-Tobias , Tscheikner-Gratl Franz , Viklander Maria , Muthanna Tone Merete 
Published: June 2024

ABSTRACT

In this study, we show that pollutants of emerging concern are, by nature, prone to the emergence of epistemic uncertainty. We also show that the current uncertainty quantification methods used for pollutant modelling rely almost exclusively on parameter uncertainty, which is not adequate to tackle epistemic uncertainty affecting the model structure. We, therefore, suggest a paradigm shift in the current pollutant modelling approaches by adding a term explicitly accounting for epistemic uncertainties. In a proof-of-concept, we use this approach to investigate the impact of epistemic uncertainty in the fluctuation of pollutants during wet-weather discharge (input information) on the distribution of mass of pollutants (output distributions). We found that the range of variability negatively impacts the tail of output distributions. The fluctuation time, associated with high covariance between discharge and concentration, is a major driver for the output distributions. Adapting to different levels of epistemic uncertainty, our approach helps to identify critical unknown information in the fluctuation of pollutant concentration. Such information can be used in a risk management context and to design smart monitoring campaigns.
A Clinical Appearance of Traumatic Fibroma with a Distinct and Rare Histological Diagnosis –insights of Pseudo Perineurioma – Case Report
Authors: Carnevalli Ana Clara Ribeiro , Dias da Silva Sara Maria Santos , da Silva Leite Larissa Sandy , de Moura Vitória Tavares , Kitakawa Dárcio , da Silva Peralta Felipe , de Lima Morais Thayná Melo , de Carvalho Luis Felipe das Chagas e Silva 
Published: June 2024

Background
Oral pseudo perineurioma is a reactive lesion of the peripheral nerve sheath rarely described in the literature, occurring more frequently in the tongue and lower lips.

Objective
The objective of this case report is to describe pseudoperineurioma with a literary basis, to encourage learning and assist in decision-making in certain situations.

Case Report
We present here a rare case of oral pseudoperineurioma in tongue that occurred in a 19-year-old man and a brief review of the literature. A 19-year-old man presented with a nodular lesion on the dorsum of the tongue without painful symptoms. Excisional biopsy was performed. The pathological examination revealed a proliferation of structures like onion bulbs. Immunohistochemical analysis was positive for GLUT-1.

Conclusion
The histological diagnosis was oral pseudoperineurioma. Oral pseudoperineurioma is a rare clinical lesion and can be confused with other reactive and neoplastic conditions of the oral cavity.
Implementasi Permainan Susun Gunung Tempurung Kelapa dalam Menstimulasi Motorik Kasar Anak Usia Dini
Authors: Nia Arianti Ni Komang , Anadhi I Made Gede , Sindu Putra Ida Bagus Komang 
Published: June 2024

Permainan tradisional menjadi salah satu kegitan yang dapat dijadikan media stimulasi tumbuh kembang anak usia dini. Permainan tradisional Susun Gunung Tempurung Kelapa merupakan permainan yang dilakukan dengan berkelompok. Penelitian ini bertujuan untuk menganalisis implementasi permainan tradisional Susun Gunung Tempurung Kelapa dalam stimulasi perkembangan motorik kasar anak. Penelitian ini menggunakan metode penelitian tindakan kelas. Objek penelitian ini yaitu anak-anak yang berjumlahkan 20 anak. Teknik pengumpulan data dengan observasi. Hasil penelitian menunjukkan bahwa permainan Susun Gunung Tempurung Kelapa dapat melatih keterampilan motorik kasar, kognitif, kreativitas, dan melatih konsentrasi anak. Penelitian ini penyimpulkan bahwa permainan susun gunung mampu menstimulasi perkembangan motorik kasar.
Keefektifan Penggunaan Alat Peraga Montessori untuk Mengembangkan Kemampuan Mengenal Konsep Bilangan Anak Usia 4-5 Tahun
Authors: Taneo Semi Stefanus , Admoko Adi , Wiyono Bambang Budi 
Published: June 2024

Penggunaan alat peraga memiliki pengaruh dalam meningkatkan kemampuan konsep bilangan pada anak usia dini. Penelitian ini bertujuan untuk melihat proses penggunaan alat peraga Montessori serta melihat dampak yang didapatkan setalah menggunakan alat peraga Montessori. Penelitian ini merupakan penelitian kualitatif yang menggunakan teknik analisis seperti pengumpulan data, kondensasi data, tampilan data, dan penarikan/verifikasi kesimpulan. Teknik pengumpulan data dalam studi ini melibatkan wawancara, observasi, dan dokumentasi. Hal ini dilakukan dengan tujuan agar mendapatkan hasil yang valid dan tepercaya. Hasil penelitian menunjukkan bahwa agar alat peraga efektif maka dilakukan melalui perencanaan, pelaksanaan dan evaluasi sehingga dapat ditunjukkan bahwa penggunaan alat peraga Montessori. Alat peraga Montessori dapat digunakan sebagai solusi dalam mengembangkan kemampuan mengenal konsep bilangan anak usia dini.
Acceptance of Social Media Recruitment for Clinical Studies Among Patients With Hepatitis B: Mixed Methods Study
Authors: Willem Theresa , Zimmermann Bettina M , Matthes Nina , Rost Michael , Buyx Alena 
Published: June 2024

Background
Social media platforms are increasingly used to recruit patients for clinical studies. Yet, patients’ attitudes regarding social media recruitment are underexplored.

Objective
This mixed methods study aims to assess predictors of the acceptance of social media recruitment among patients with hepatitis B, a patient population that is considered particularly vulnerable in this context.

Methods
Using a mixed methods approach, the hypotheses for our survey were developed based on a qualitative interview study with 6 patients with hepatitis B and 30 multidisciplinary experts. Thematic analysis was applied to qualitative interview analysis. For the cross-sectional survey, we additionally recruited 195 patients with hepatitis B from 3 clinical centers in Germany. Adult patients capable of judgment with a hepatitis B diagnosis who understood German and visited 1 of the 3 study centers during the data collection period were eligible to participate. Data analysis was conducted using SPSS (version 28; IBM Corp), including descriptive statistics and regression analysis.

Results
On the basis of the qualitative interview analysis, we hypothesized that 6 factors were associated with acceptance of social media recruitment: using social media in the context of hepatitis B (hypothesis 1), digital literacy (hypothesis 2), interest in clinical studies (hypothesis 3), trust in nonmedical (hypothesis 4a) and medical (hypothesis 4b) information sources, perceiving the hepatitis B diagnosis as a secret (hypothesis 5a), attitudes toward data privacy in the social media context (hypothesis 5b), and perceived stigma (hypothesis 6). Regression analysis revealed that the higher the social media use for hepatitis B (hypothesis 1), the higher the interest in clinical studies (hypothesis 3), the more trust in nonmedical information sources (hypothesis 4a), and the less secrecy around a hepatitis B diagnosis (hypothesis 5a), the higher the acceptance of social media as a recruitment tool for clinical hepatitis B studies.

Conclusions
This mixed methods study provides the first quantitative insights into social media acceptance for clinical study recruitment among patients with hepatitis B. The study was limited to patients with hepatitis B in Germany but sets out to be a reference point for future studies assessing the attitudes toward and acceptance of social media recruitment for clinical studies. Such empirical inquiries can facilitate the work of researchers designing clinical studies as well as ethics review boards in balancing the risks and benefits of social media recruitment in a context-specific manner.
A Randomized Controlled Clinical Trial Testing Effects of Lademirsen on Kidney Function Decline in Adults with Alport Syndrome
Authors: Gale Daniel P. , Gross Oliver , Wang Fang , Esteban de la Rosa Rafael José , Hall Matthew , Sayer John A. , Appel Gerald , Hariri Ali , Liu Shiguang , Maski Manish , Shen Yuqian , Zhang Qi , Iqbal Sajida , Kowthalam Madhurima Uppara , Lin Julie , Ding Jie ,   on behalf of the HERA Clinical Trial Group
Published: June 2024

Key Points

Lademirsen, an anti–microRNA-21 therapy, was generally well-tolerated in adults with Alport syndrome at risk of rapid disease progression.There were no significant differences between lademirsen-treated and placebo-treated participants in eGFR at any timepoint.The proportions of participants with prespecified reductions in eGFR at weeks 24 and 48 were not significantly different for lademirsen versus placebo.

Background
Preclinical models of disease have suggested that targeting microRNA-21 (miRNA-21) may slow the decline in kidney function in individuals with Alport syndrome (AS). The objective of this study was to investigate the effects of the anti–miRNA-21 oligonucleotide, lademirsen, on rate of eGFR decline in adults with AS at risk of rapid disease progression.

Methods
This study was a phase 2 trial of lademirsen, with a randomized, double-blind, placebo-controlled period followed by an open-label period. Adults with AS, eGFR >35 to <90 ml/min per 1.73 m2, and evidence of rapidly progressive kidney dysfunction were randomized 2:1 to lademirsen 110 mg subcutaneously once weekly or placebo for 48 weeks. After a planned interim analysis (after 24 of 43 randomized participants completed the week 48 study visit or discontinued before week 48), the trial was terminated for futility.

Results
Forty-three adults with AS (26 men, 17 women) participated (mean age 34 years), and 28 (lademirsen: n=19; placebo: n=9) completed 48 weeks of double-blind treatment. All participants in both groups developed treatment-emergent adverse events, mainly respiratory tract infections, headache, dizziness, metabolic/electrolyte disturbances, and anemia. Treatment was discontinued in three lademirsen-treated participants in the double-blind period and one participant in the open-label period, owing to treatment-emergent adverse events. The least squares mean eGFR slope (95% confidence interval) over 48 weeks in the lademirsen and placebo groups was −5 (−8.7 to −1.1) and −5 (−10.2 to 0.8) ml/min per 1.73 m2 per year, respectively. No significant differences between groups were identified in eGFR at any timepoint or in proportion of participants with prespecified reductions in eGFR at week 24 or 48.

Conclusions
While anti–miRNA-21 therapy with lademirsen was generally well-tolerated with an acceptable safety profile, no meaningful improvement in rate of kidney function decline in adults with AS at risk of rapidly progressive disease was observed.

Clinical Trial registration number:

NCT02855268.
Penerapan managemen kelas untuk meningkatkan karakter disiplin siswa di sekolah dasar
Authors: Kurniawati  , Sutisnawati Astri , Hamdani Maula Luthfi 
Published: June 2024

Penelitian ini didasari oleh kurangnya partisipasi siswa dalam belajar serta tingkat kedisiplinan yang masih kurang yang berimbas pada hasil belajar PPKn siswa, dan hal tersebut berdampak pada tujuan capaian belajar yang belum tercapai maksimal. Peneliti menggunakan pendekatan penelitian tindakan kelas. Terdapat 25 siswa yang menjadi subjek penelitian di kelas I SD Negeri Mekarjaya. Penelitian ini dilakukan melalui dua siklus, mencakup fase perencanaan, pelaksanaan, observasi, dan refleksi. Selama proses pembelajaran, pengumpulan data dan pelaksanaan penelitian dilakukan bersama. Hasil penelitian menunjukan bahwa implementasi manajemen kelas mampu meningkatkan hasil belajar Pendidikan Pancasila dan Kewarganegaraan (PKKN) serta kedisiplinan siswa kelas I SD Negeri Mekarjaya. Temuan penelitian menunjukkan bahwa pada awalnya, hanya 9 dari 25 siswa yang memenuhi kriteria kelulusan, sedangkan sisanya tidak. Namun, setelah dilakukan Siklus I, jumlah siswa yang memenuhi kriteria meningkat menjadi 18, dengan hanya 7 siswa yang tidak memenuhi kriteria. Dan pada Siklus II, 23 siswa berhasil mencapai kriteria kelulusan yang ditetapkan dan hanya 2 orang siswa yang masih di bawah KKM. Adapun persentase kelulusan pada pra-siklus hanya mencapai 32%, kemudian meningkat menjadi 72% pada Siklus I, dan mencapai 92% pada Siklus II, melebihi target yang telah ditetapkan sebesar 80%. Selain itu pada aspek kedisiplinan hasil observasi pada kegiatan tahap siklus 1 memiliki peningkatan menuju siklus II. Pada siklus II terlihat bahwa peningkatan setiap indicator kedisiplinannya sangat meningkat secara signifikan, sehingga dalam indicator ketaatan waktu belajar mendapatkan presentase sebesar 81%, indicator ketaatan mengerjakan tugas sebesar 82%, indicator ketaatan waktu datang dan pulang sebesar 93% dan indicator terkait pelaksanaan kegiatan diperoleh presentase sebesar 93%. Sehingga pada siklus II termasuk ke dalam kategori “sangat baik” Dengan demikian, penerapan penggunaan penggunaan manajemen kelas guna meningkatkatkan karakter disiplin dan hasil belajar siswa di SDN Mekarjaya terbukti berhasil.
Pengembangan buku interaktif untuk meningkatkan pemahaman siswa sekolah dasar terhadap materi pola hidup gotong – royong pada kelas III
Authors: Tirtoni Feri 
Published: June 2024

Abstrak
. Artikel ini bertujuan untuk mengembangkan buku interaktif sebagai alat pembelajaran yang efektif untuk meningkatkan pemahaman siswa kelas III terhadap materi pola hidup gotong-royong. Penelitian ini menggunakan pendekatan penelitian dan pengembangan dengan langkah-langkah pengembangan menurut model ADDIE (Analysis, Design, Development, Implementation, dan Evaluation). Pada tahap analisis, dilakukan studi literatur dan observasi awal untuk mengidentifikasi kebutuhan siswa serta hambatan yang dihadapi dalam pemahaman materi pola hidup gotong-royong. Selanjutnya, tahap desain mencakup perencanaan konten, struktur, dan fitur interaktif yang akan disajikan dalam buku interaktif. Kemudian, dalam tahap pengembangan, buku interaktif dirancang dan diproduksi menggunakan teknologi digital yang sesuai dengan kebutuhan siswa. Setelah itu, tahap implementasi dilakukan dengan menguji coba buku interaktif pada siswa kelas III di sebuah sekolah dasar. Selama proses implementasi, data diperoleh melalui observasi, tes, dan angket untuk mengukur pemahaman siswa terhadap materi pola hidup gotong-royong. Terakhir, tahap evaluasi dilakukan untuk mengevaluasi keefektifan buku interaktif dalam meningkatkan pemahaman siswa. Hasil penelitian menunjukkan bahwa penggunaan buku interaktif dapat signifikan meningkatkan pemahaman siswa terhadap materi pola hidup gotong-royong. Selain itu, siswa juga menunjukkan minat dan motivasi yang tinggi dalam menggunakan buku interaktif ini sebagai sarana pembelajaran. Temuan ini menunjukkan bahwa buku interaktif dapat menjadi alternatif yang efektif dalam meningkatkan pembelajaran tentang pola hidup gotong-royong pada siswa kelas III.
Kata Kunci: Pancasila; pengembangan buku interaktif, pemahaman siswa, pola hidup gotong-royong, sekolah dasar, kelas III.
Estágio Curricular Supervisionado: O Currículo de Pedagogia da Universidade Federal da Grande Dourados
Authors: Rocha Cristiane Ribeiro Cabral , Alencar Edvonete Souza de 
Published: June 2024

O presente artigo aborda aspectos teóricos acerca do Estágio Curricular Supervisionado, tendo por objetivo analisar o currículo do Curso de Pedagogia da Universidade Federal da Grande Dourados (UFGD), bem como as possibilidades e limites do Estágio na Formação de Professores. É uma pesquisa de cunho qualitativo de análise documental e teórica. A partir da análise do Projeto Pedagógico do curso, foi possível evidenciar que o Estágio possibilita a formação de um profissional crítico-reflexivo, fator esse que se dá pelo tempo e permanência dos acadêmicos no ambiente escolar, onde as atividades teórico-práticas são possibilitadas diante da diversidade e multiplicidade de questões inerentes à organização escolar. Os desafios observados pelos futuros docentes são problematizados à luz da teoria no ambiente acadêmico, o que torna contínua a relação universidade e escola. Por fim, compreender o Estágio como um movimento formativo profícuo de ensino e pesquisa, principalmente, em ampliação de carga horária e como componente curricular com um regimento próprio, assim como apresenta o Projeto Pedagógico do curso de Pedagogia da UFGD, possibilita uma formação docente com potencialidades e experiências, munindo-os de uma bagagem sólida de conhecimento crítico, social e reflexivo, para uma atuação profissional duradoura.
Higher Genetic Risk for Type 2 Diabetes Is Associated With a Faster Decline of β-Cell Function in an East Asian Population
Authors: Lee Hyunsuk , Choi Jaewon , Kim Jong-Il , Watanabe Richard M. , Cho Nam H. , Park Kyong Soo , Kwak Soo Heon 
Published: June 2024

OBJECTIVE
While most genetic variants of type 2 diabetes (T2D) are suggested to be associated with β-cell dysfunction cross sectionally, their association with the longitudinal change of β-cell function remains largely unknown.

RESEARCH DESIGN AND METHODS
We analyzed data from 6,311 participants without T2D at baseline (mean [SD] age 51.6 [8.7] years) from a community-based prospective cohort in Korea. Participants underwent biennial 2-h 75-g oral glucose tolerance tests (OGTTs) during 14 years of follow-up, and the OGTT-derived disposition index (DI) was used as a marker for β-cell function. Genetic risk was quantified using the genome-wide polygenic risk score (PRS) and was stratified into low (1st quintile), intermediate (2nd–4th quintiles), and high (5th quintile) genetic risk. Lifestyle was assessed according to Life’s Essential 8.

RESULTS
During a mean follow-up of 10.9 years, 374 (29.6%), 851 (22.5%), and 188 (14.9%) participants developed T2D in the high, intermediate, and low genetic risk groups, respectively. Compared with the low genetic risk group, participants in the high genetic risk group had a 25% lower DI at baseline. Furthermore, in longitudinal analysis, we observed a 1.83-fold faster decline in log2-transformed DI per year (−0.034 vs. −0.019, P = 2.1 × 10−3; per 1-SD increase in T2D PRS, P = 1.2 × 10−4). Healthy lifestyle attenuated the rate of decline in DI across all genetic risk groups.

CONCLUSIONS
Individuals with a higher genetic risk for T2D exhibited not only a lower OGTT-derived β-cell function at baseline but also a notably more rapid decline during follow-up. This information could be used to enable a focused precision prevention with lifestyle intervention.
Prototyping a Disruptive Self-Sustaining Power Plant enabled to overcome Perpetual Motion Machines
Authors: Ferreiro Garcia Ramon 
Published: June 2024

This research discusses a strategic methodology for implementing a disruptive Self-Sustaining Power Plant (SSPP) characterized by the cascading coupling of a group of Power Units (PUs). In this configuration, the heat released from each PU due to the cooling of the thermal working fluid (TWF) is efficiently recovered and reused as supply heat for the first PU in the cascade. Two case studies on the SSPP have been conducted using air and helium as TWFs. The first deals with PUs coupled in cascade operating with closed processes-based Vsp thermal cycles, while the second involves PUs coupled in cascade operating with closed processes-based VsVs thermal cycles. Following the corresponding analysis of both case studies, significant results were obtained. These results, derived from this preliminary design study, will be applied to the implementation of the disruptive SSPP prototype operating with real gases as working fluids. This allows for a precise and clear understanding of the issue of generating useful work through expansion, contraction, or both. Moreover, according to the results, the SSPP composed by a group of power units where the efficiency of each power unit operating with air as working fluid only approaches a value of the efficiency of 22%, can exceed 100% of the nominal design power under certain conditions, which supposes a flagrant violation of the principle of conservation of energy due to the fact that such disruptive Self-Sustaining Power Plant is enabled to overcome a Perpetual Motion Machine of second kind.