bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic‐assisted microwave ablation for hepatocellular carcinoma: Safety and efficacy in comparison with radiofrequency ablation
Authors: Simo Kerri A. , Sereika Stephanie E. , Newton Kimberly N. , Gerber David A. 
Published: April 2011

AbstractBackgroundThermal ablation techniques are increasingly important in the search for improved locoregional therapy of hepatocellular carcinoma (HCC) in patients with cirrhosis. This study reports the largest US series using laparoscopic‐assisted microwave ablation (Lap‐MWA) with a 915‐MHz generator for HCC and compares it with a contemporary laparoscopic‐assisted radiofrequency ablation (Lap‐RFA) experience.MethodsThirty‐five patients with HCC underwent laparoscopic‐assisted ablation utilizing either MWA or RFA. Medical records, radiographic imaging, and histology were reviewed and outcomes analyzed.ResultsTwenty‐two patients underwent Lap‐RFA (27 tumors) and 13 received Lap‐MWA (15 tumors). Average ablation volumes were similar for Lap‐RFA and Lap‐MWA at 23.43 and 28.99 cm3, respectively (=0.69). Average operative times for Lap‐RFA were 149 ± 35 min versus 112 ± 40 min with Lap‐RFA (P = 0.004). Mean follow‐up was 19 months in the Lap‐RFA group: 50% alive without evidence of disease, 9% alive with disease, 36% deceased and 5% lost to follow‐up. Mean follow‐up in the Lap‐MWA group was 7 months: 54% alive without evidence of disease, 31% alive with disease and 15% deceased.ConclusionLap‐MWA is a safe and efficacious locoregional therapy for HCC which achieves outcomes comparable to Lap‐RFA. Shorter operative times were realized with this modality and complete coagulative necrosis was confirmed histologically on explanted livers. J. Surg. Oncol. 2011; 104:822–829. © 2011 Wiley Periodicals, Inc.
Neoadjuvant GTX Chemotherapy and IMRT‐based chemoradiation for borderline resectable pancreatic cancer
Authors: Patel Manish , Hoffe Sarah , Malafa Mokenge , Hodul Pamela , Klapman Jason , Centeno Barbara , Kim Jongphil , Helm James , Valone Tiffany , Springett Gregory 
Published: April 2011

AbstractBackground and ObjectivesTo improve the likelihood of achieving a margin‐free resection, neoadjuvant induction chemotherapy with GTX (gemcitabine, docetaxel, and capecitabine) followed by 5‐FU‐IMRT was administered to patients with borderline resectable pancreatic cancer. The utility of computed tomography (CT), endoscopic ultrasound (EUS), positron emission tomography (PET), and CA 19‐9 during diagnostic workup and assessment of response was also examined.MethodsSeventeen patients with borderline resectable pancreatic cancer received a median of three cycles of neoadjuvant GTX induction chemotherapy followed by 5‐FU‐IMRT with dose painting. CA 19‐9, CT mass size, and PET SUV were examined before and after neoadjuvant treatment.ResultsDiagnostic EUS and CT scans displayed similar mean mass sizes and extent of vascular involvement. Eight of the 17 patients achieved an R0 resection. Median CA 19‐9 levels, CT mass size, and PET SUV all significantly decreased after neoadjuvant therapy. The median progression‐free survival and overall survival were 10.48 and 15.64 months, respectively. Six patients are still alive.ConclusionsNeoadjuvant GTX induction chemotherapy followed by 5‐FU‐IMRT shows promise in improving the likelihood of resectability with negative margins in borderline resectable pancreatic cancer. CT and EUS play complimentary roles during diagnostic workup. CT scans, CA 19‐9, and PET scans are useful in judging response to neoadjuvant therapy. J. Surg. Oncol. 2011;104:155–161. © 2011 Wiley‐Liss, Inc.
Rate coefficients for the O(3P) + Cl2O gas‐phase reaction between 230 and 357 K
Authors: Papanastasiou Dimitrios K. , Burkholder James B. 
Published: April 2011

AbstractRate coefficients, k, for the gas‐phase reaction of O(3P) atoms with Cl2O (dichlorine monoxide) over a range of temperatures (230–357 K) at pressures between 12 and 32 Torr (N2) are reported. Rate coefficients were measured under pseudo‐first‐order conditions in O(3P) using pulsed laser photolysis to produce O(3P) atoms and atomic resonance fluorescence to detect its temporal profile. The rate coefficient temperature dependence is given by the Arrhenius expression k(T) = (1.51 ± 0.20) × 10−11 exp[−(477 ± 30)/T] cm3 molecule−1 s−1, and k(296 K) was measured to be (2.93 ± 0.30) × 10−12 cm3 molecule−1 s−1. The quoted uncertainty limits are at the 2σ (95% confidence) level and include estimated systematic errors. The rate coefficients determined in the present study, under conditions that minimized secondary losses of O(3P), are compared with previous results from other laboratories and the discrepancies are discussed. © 2011 Wiley Peiodicals, Inc.*This article is a U.S. Government work and, as such, is in the public domain of the United States of America.
Int J Chem Kinet 43: 312–321, 2011
Transparapharyngeal and transpterygoid transposition of a pedicled occipital galeopericranial flap: A new flap for skull base reconstruction
Authors: Rivera‐Serrano Carlos M. , Snyderman Carl H. , Carrau Ricardo L. , Durmaz Abdullah , Gardner Paul A. 
Published: April 2011

AbstractObjectives:We present the anatomic and cadaveric foundations for novel modifications of the occipital galeopericranial flap for reconstruction of ventral skull base defects.Study Design:Anatomic description.Methods:Using cadaveric dissections and measurements, we investigated the feasibility of transposing pedicled occipital galeopericranial flaps into the nasal cavity and skull base. Two fresh and five preserved human specimens were dissected.Results:Pedicled occipital flaps were transposed into the nasal cavity via a transparapharyngeal–transpterygoid corridor into the nasopharynx. It was demonstrated that the pedicled occipital galeopericranial flap reaches the anterior skull base.Conclusions:Pedicled occipital flaps transposed into the nasal cavity can reach the anterior skull base and provide another option for vascularized reconstruction in selected patients.
Malignancy in vestibular schwannoma after stereotactic radiotherapy: A case report and review of the literature
Authors: Tanbouzi Husseini Sami , Piccirillo Enrico , Taibah Abdelkader , Paties Carlo T. , Rizzoli Roberto , Sanna Mario 
Published: April 2011

AbstractObjectives/Hypothesis:A relation between conventional radiotherapy and the development of intracranial neoplasma is well known, but radiation‐associated tumor following stereotactic radiotherapy of vestibular schwannoma is underestimated.   In this article we will study this relation by doing a complete literature review on all the malignant intracranial tumors that appeared following radiosurgery and adding a case of malignant vestibular schwannoma following stereotactic radiotherapy in a Neurofibromatosis type 2 patient.Methods:Literature review and discussion.Results:We found 26 cases of malignant brain tumor following stereotactic radiotherapy including our case. In 13 cases the tumor occurred in context of Neurofibromatosis type 2. None of the patients had a tumor size less than 2.5 cm. and the mean latency period between the radiotherapy and malignant tumor development was 5.8 years.Conclusion:Patients with vestibular schwannoma should be made aware of the low incidence of the radiation‐induced malignant changes and long‐term follow‐up is mandatory.
Viagra deafness—Sensorineural hearing loss and phosphodiesterase‐5 inhibitors
Authors: Khan Afroze Shah , Sheikh Zishan , Khan Shahnawaz , Dwivedi Raghav , Benjamin Elliot 
Published: April 2011

AbstractBackground:Viagra and PDE‐5 inhibitors use has mushroomed since its launch over a decade ago. A growing body of evidence indicates significant morbidity associated with the side effect profile of this class of drug. Hearing loss associated with PDE‐5 inhibitor use has recently been reported, but few studies have evaluated the causal link.Aim:To review and scrutinise the current literature on the subject and propose possible physiologic mechanisms and to investigate the global reporting of this side effect.Methods and Materials:Pharmacovigilance agencies around North America, Europe, and Australasia were contacted requesting reports of hearing loss associated with PDE‐5 inhibitors. Reports were scrutinised to exclude those where others causes of hearing loss existed.Results:Forty‐seven cases of sensorineural hearing loss with a temporal association with PDE‐5 inhibitor ingestion were obtained from both published literature and pharmacovigilance agencies. Cases had a mean age 56.6 years, male‐to‐female ratio of 7:1. Eighty‐eight percent of reports were unilateral with an even left/right distribution. Hearing loss occurred within 24 hours of ingestion of PDE‐5 inhibitor in 66.7% (n = 18) of cases. Sildenafil accounted for over 50% of cases.Conclusion:There is increasing evidence that PDE‐5 inhibitors may induce sensorineural hearing loss via plausible physiological mechanisms. There needs to be more awareness of this disabling side effect among healthcare professionals responsible for prescribing this drug.
Amyloid goiter: A case of primary thyroid amyloid disease
Authors: Sethi Yatin , Gulati Achal , Singh Ishwar , Rao Seema , Singh Neha 
Published: April 2011

AbstractAmyloid goiter is an atypical presentation of an already rare disease, amyloidosis, which uncommonly comes across in previous review of literature. A patient presented with respiratory distress, which aroused a dilemma on diagnosis because the presentation mimicked that of malignancy. A high index of attentiveness should be kept whenever amyloid deposits are seen on fine needle aspiration cytology, as they are also established in medullary carcinoma. Amyloid deposits have been traced in goiter; however, it was astonishing to observe this condition causing a rapidly growing goiter, large enough to cause respiratory distress. The confirmative diagnosis rested on the histopathology of the specimen.
Superficial ulnar artery: A contraindication to radial forearm free tissue transfer
Authors: Bell Rachel A. , Schneider Daniel S. , Wax Mark K. 
Published: April 2011

AbstractObjectives:Superficial ulnar artery is a vascular anomaly that may be encountered during elevation of forearm flaps for head and neck reconstruction. This anomaly should be considered in patients with a positive Allen's test.Study Design:Case report and retrospective review of forearm flaps performed at our institution.Methods:A 72‐year‐old man with a history of total laryngectomy presented for closure of a pharyngocutaneous fistula with radial forearm flap. A positive Allen's test and undetectable Doppler over the thenar eminence with radial artery occlusion was noted. An ulnar flap was felt to be the best alternative. A superficial ulnar artery was discovered upon elevation of the ulnar flap. Despite its anomalous course, the artery provided several fasciocutaneous branches, and the flap was successfully used to repair the patient's fistula. A retrospective review of forearm flaps and the incidence of superficial ulnar artery at our institution is presented.Results:A total of 690 forearm flaps (571 radial, 51 ulnar, and 68 osteocutaneous radial) were performed from 1998 to 2010. Superficial ulnar artery was encountered three times, yielding an incidence of 0.43%. In each case, the preoperative Allen's test suggested a dominant radial artery circulation. In all cases, a fasciocutaneous ulnar flap was successfully used.Conclusions:Superficial ulnar artery should be considered with a positive Allen's test. An ulnar fasciocutaneous flap based on the superficial ulnar artery is a safe alternative to the radial fasciocutaneous flap in this setting.
Comparison of full versus short induced‐sleep polysomnography for the diagnosis of sleep apnea
Authors: Gregório Marcelo G. , Jacomelli Márcia , Inoue Daniel , Genta Pedro Rodrigues , de Figueiredo Adelaide Cristina , Lorenzi‐Filho Geraldo 
Published: April 2011

AbstractObjectives/Hypothesis:Polysomnography (PSG) is the gold‐standard method for diagnosing obstructive sleep apnea (OSA). However, the gap between demand and capacity in performing PSG is a major health‐care problem. We sought to validate a short day‐time induced sleep for the diagnosis of OSA.Study Design:Prospective diagnostic method validation.Methods:We studied 25 consecutive patients referred to the sleep laboratory and 15 healthy volunteers. All subjects were evaluated by means of full overnight PSG (Full‐PSG) and short day‐time induced‐sleep PSG (Induced‐PSG). Sleep was monitored during both procedures (Embla, 16 channels). Sleep was induced by slow intravenous drip infusion of midazolam.Results:The population studied (N = 40) was 60% male (mean age, 42 ± 10 years; body mass index, 29 ± 6.5 kg/m2). Sleep was successfully induced in all subjects, and no complications were observed (midazolam doses, 6.2 ± 3.8 mg; time of induced sleep 41.5 ± 18.9 minutes). The apnea‐hypopnea index (AHI) and minimal oxygen saturation during Full‐PSG versus Induced‐PSG were similar: median AHI (with 25%–75% interquartile range) was 13 (3–35) events per hour versus 17 (4–36) events per hour, and median oxygen saturation was 84% (75–90) versus 85% (76–92); P =.89 and P =.53, respectively. The majority of the respiratory events during induced sleep were obstructive and similar to those observed during Full‐PSG. AHI and lowest oxygen saturation during Induced‐PSG correlated significantly with Full‐PSG (r = 0.67 and r = 0.77, respectively). Sensitivity and specificity for the diagnosis of OSA (AHI > 15 events per hour) by Induced‐PSG were 0.83 and 0.72, respectively.Conclusions:Induced‐PSG by midazolam during the day is safe and correlates with Full‐PSG; it therefore is a promising alternative method in the diagnosis of OSA.
Idiopathic ulcerative laryngitis
Authors: Simpson C. Blake , Sulica Lucian , Postma Gregory N. , Rosen Clark A. , Amin Milan R. , Merati Albert L. , Courey Mark S. , Patel Vatsal , Johns Michael M. 
Published: April 2011

AbstractObjectives/Hypothesis:Idiopathic ulcerative laryngitis (IUL) is a distinct, clinical entity that presents after a prolonged upper respiratory infection with cough. It is characterized by the development of bilateral ulcerations of the mid‐membranous vocal folds followed by a protracted course of healing. The purpose of this review was to characterize the typical patient presentation, clinical findings, and prognosis.Study Design:Multi‐institutional retrospective reviewMethods:Retrospective review of charts and videostroboscopic exams from patients with IUL at eight institutions.Results:Fifteen cases met the criteria for IUL and were included in the study. The mean age of the patients was 49 years, and 93% were female. All patients were nonsmokers. Multiple medical interventions were employed by the treating otolaryngologist during the course of the disease, none of which resulted in acute resolution of the ulcerations. The average time from initial presentation to resolution of the disease was 3.3 months. All of the patients reported that their voice was improved after resolution of the disease process. However, in the majority of the patients (60%) there were persistent vibratory abnormalities after resolution of the ulcerations.Conclusions:This is the first multi‐institutional study to define the complete disease course of IUL and to establish diagnostic criteria. IUL is a rare yet well‐recognized clinical entity; however, there is no established etiology for this condition and no definitive treatments have emerged. Further study is needed to establish the etiology/risk factors of this condition and to determine optimal medical management.
Methylglyoxal‐infused honey mimics the anti‐Staphylococcus aureus biofilm activity of manuka honey: Potential Implication in Chronic Rhinosinusitis
Authors: Jervis‐Bardy Joshua , Foreman Andrew , Bray Sarah , Tan Lorwai , Wormald Peter‐John 
Published: April 2011

AbstractObjectives/Hypothesis:Low pH, hydrogen peroxide generation, and the hyperosmolarity mechanisms of antimicrobial action are ubiquitous for all honeys. In addition, manuka honey has been shown to contain high concentrations of methylglyoxal (MGO), contributing the relatively superior antimicrobial activity of manuka honey compared to non‐MGO honeys. In high concentrations, manuka honey is effective in killing Staphylococcus
aureus biofilms in vitro. Lower concentrations of honey, however, are desirable for clinical use as a topical rinse in chronic rhinosinusitis in order to maximize the tolerability and practicality of the delivery technique. This study, therefore, was designed to evaluate the contribution of MGO to the biofilm‐cidal activity of manuka honey, and furthermore determine whether the antibiofilm activity of low‐dose honey can be augmented by the addition of exogenous MGO.Study Design:In vitro microbiology experiment.Methods:Five S.
aureus strains (four clinical isolates and one reference strain) were incubated to form biofilms using a previously established in vitro dynamic peg model. First, the biofilm‐cidal activities of 1) manuka honey (790 mg/kg MGO), 2) non‐MGO honey supplemented with 790 mg/kg MGO, and 3) MGO‐only solutions were assessed. Second, the experiment was repeated using honey solutions supplemented with sufficient MGO to achieve concentrations exceeding those seen in commercially available manuka honey preparations.Results:All honey solutions containing a MGO concentration of 0.53 mg/mL or greater demonstrated biofilm‐cidal activity; equivalent activity was achieved with ≥1.05 mg/mL MGO solution.Conclusions:MGO is only partially responsible for the antibiofilm activity of manuka honey. Infusion of MGO‐negative honey with MGO, however, achieves similar cidality to the equivalent MGO‐rich manuka honey.
Do contemporary temporal bone fracture classification systems reflect concurrent intracranial and cervical spine injuries?
Authors: Sun Gordon H. , Shoman Nael M. , Samy Ravi N. , Cornelius Rebecca S. , Koch Bernadette L. , Pensak Myles L. 
Published: April 2011

AbstractObjectives/Hypothesis:Temporal bone fractures (TBFs) are a frequent manifestation of head trauma. We investigated the prevalence of concurrent intracranial injuries (ICIs) and cervical spine injuries (CSIs) in a series of patients with TBFs and attempted to identify significant associations between current TBF classification systems and either ICI or CSI.Study Design:Retrospective case series with chart review.Methods:The records of all patients ≥18 years of age diagnosed with a basilar skull fracture, including TBF, at a level I trauma center from 2004 to 2009 were reviewed. Patient demographics, mechanism of injury, and Glasgow Coma Scale (GCS) scores were collected. Imaging studies were reviewed to classify TBF using the traditional longitudinal‐transverse‐mixed and otic capsule–sparing versus –involving systems and identify concurrent ICI and CSI.Results:Of 1,279 patients, 202 (15.8%) met inclusion criteria. There were 160 (79.2%) males. Sixteen (7.9%) patients had bilateral TBFs. Falls (n = 66, 32.7%) represented the most common mechanism for TBF. Longitudinal (n = 96, 44.0%) and otic capsule–sparing (n = 209, 95.9%) fractures were the most prevalent subtypes. There were 184 (91.1%) patients who sustained ICI and 18 (8.9%) who demonstrated CSI. Longitudinal, transverse, mixed, otic capsule–sparing, or otic capsule–involving TBF subtypes had no statistically significant associations with mechanism of injury, GCS score, or concomitant ICI or CSI.Conclusions:More than 90% of patients sustaining TBF presented with concomitant ICI, and 9% sustained CSI. Current TBF classification systems do not correlate with these outcomes. A more sophisticated, multidisciplinary classification system encompassing radiographic and clinical findings may better predict neurologic, neuro‐otologic, and skull base complications.
Narrow‐band imaging for diagnosing adenoid hypertrophy in adults: A simplified grading and histologic correlation
Authors: Wang Wen‐Hung , Lin Yen‐Chun , Weng Hsu‐Huei , Lee Kam‐Fai 
Published: April 2011

AbstractObjectives/Hypothesis:To investigate the use of narrow‐band imaging (NBI) endoscopy to detect the appearance of a light crest (LC) on the epithelial surface of the nasopharyngeal mucosa, which is suggested to be a distinctive endoscopic finding associated with the presence of adenoid hypertrophy.Study Design:Cross‐sectional study.Methods:A total of 79 consecutive adults with a high suspicion of malignancy underwent NBI endoscopy and nasopharyngeal biopsy to validate the diagnostic accuracy of the novel endoscopic technique. The degree of correlation between the LC grading and the histologic examinations of lymphoid hyperplasia, including the number of mucin‐producing cells and lymphoid follicles, was then assessed.Results:The appearance of an LC on NBI endoscopy correlated with the histologic evidence of lymphoid hyperplasia with a sensitivity of 92.1%, a specificity of 95.1%, a positive predictive value of 94.6%, a negative predictive value of 92.9%, a false‐positive value of 4.9%, a false‐negative value of 7.9%, and an accuracy of 93.7%. The screening performance of NBI endoscopy for the presence of adenoid hypertrophy is significantly superior to that of conventional endoscopy (P =.0003). The LC grading was significantly correlated with the number of mucin‐producing cells and lymphoid follicles (P <.001).Conclusions:In NBI endoscopy, observation of an LC on the epithelial surface of the nasopharyngeal mucosa is a highly accurate predictor of the presence of adenoid hypertrophy.
Transantral balloon dilation plus posterior ethmoidectomy
Authors: Kizhner Victor , Setzen Michael , Krespi Yosef P. 
Published: April 2011

AbstractObjectives/Hypothesis:Transantral endoscopic balloon dilatation (TABD) was recently introduced for the management of limited mild maxillary and ethmoid disease. An expanded approach by inserting surgical tools into the antrum via a second port, directed toward the maxillary ostium, ethmoid infundibulum, and posterior ethmoids will allow for the treatment of moderate disease as well.Study Design:Retrospective data review.Methods:A study including all TABD procedures performed between January and December 2009 was performed. Sublabial approach with two working channels, one for the endoscope and a second port for balloon dilatation or other surgical instrumentation, was devised. Both channels were created via mini‐trephine aimed toward the osteo‐meatal complex (OMC) with different angulations. The same approach was used for transantral posterior ethmoidectomy (TAPE). Data collected included demographics, Sino‐Nasal Outcome Test (SNOT) scores, Lund‐Mackay score, and complications.Results:Thirty‐five patients with 64 dilated sinuses and 10 TAPE procedures were enrolled. All SNOT scores showed statistically significant improvement decreasing from 1.77 to 0.83. Complication rate was minimal. Only a small number of procedures were converted to standard endoscopic septoplasty (ESS) owing to severity of OMC disease. TAPE proved to be a minimally invasive procedure.Conclusions:Two trocars inserted through the canine fossa can achieve a successful result in moderate antral disease for TABD and allow TAPE to be performed, thus creating a bridge between mild disease and one requiring standard full ESS. The minimally invasive approach proved to be particularly useful.