bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Naphthopyrones from Cultured Lichen Mycobionts of Pyrenula sp.
Authors: Takenaka Yukiko , Nagakura Naotaka , Hamada Nobuo , Tanahashi Takao 
Published: November 2010

AbstractThe new naphthopyrone derivative pyrenulin (I) and the known naphtho‐α‐pyrone derivative toralactone are isolated from the cultured mycobionts of the lichen Pyrenula sp.
ChemInform Abstract: The Cobalt Way to Angucyclinones: Asymmetric Total Synthesis of the Antibiotics (+)‐Rubiginone B2, (‐)‐Tetrangomycin and (‐)‐8‐O‐Methyltetrangomycin.
Authors: Kesenheimer Christian , Kalogerakis Aris , Meissner Anja , Groth Ulrich 
Published: November 2010

AbstractThe route to the title antibiotics, rubiginone B2 (III), methyltetrangomycin (VI), and tetrangomycin (VII), involves a completely regioselective [2 + 2 + 2] cycloaddition reaction of triyne precursors as key step to give tetrahydrobenzo[a]anthracene derivatives.
ChemInform Abstract: Lucknolides A and B, Tricyclic Ketal‐Lactone Metabolites from a Terrestrial Streptomyces sp.
Authors: Yadav Prem P. , Nair Vimal , Dittrich Birger , Schueffler Anja , Laatsch Hartmut 
Published: November 2010

AbstractNeither antibacterial nor antifungal activity is observed for the title compounds.
ChemInform Abstract: Flavonoids from Cleistocalyx operculatus Buds and Their Cytotoxic Activity.
Authors: Min Byung Sun , Cuong To Dao , Lee Joo‐Sang , Woo Mi Hee , Hung Tran Manh 
Published: November 2010

AbstractCompound (I) is isolated from the water‐soluble fraction of the buds of the title medicinal plant together with 6 known compounds.
ChemInform Abstract: Synthesis and Biological Evaluation of Kojyl Thioether Derivatives as Tyrosinase Inhibitors.
Authors: Rho Ho Sik , Baek Heung Soo , Ahn Soo Mi , Kim Myung Kyoo , Ghimeray Amal Kumar , Cho Dong‐Ha , Hwang Jae Sung 
Published: November 2010

AbstractTen title compounds of type (I) are prepared and tested as tyrosinase inhibitors.
ChemInform Abstract: Design and Synthesis of 4‐[3,5‐Dioxo‐11‐oxa‐4,9‐diazatricyclo [5.3.1.02,6]undec‐4‐yl]‐2‐trifluoromethyl‐benzonitriles as Androgen Receptor Antagonists.
Authors: Xiao Hai‐Yun , et al. et al. 
Published: November 2010

AbstractBased on the common structure of androgen receptor (AR) antagonists, a series of novel diazatricyclic compounds is designed.
ChemInform Abstract: Transfer Functions for Solid—Solution Partitioning of Cadmium, Copper, Nickel, Lead and Zinc in Soils: Derivation of Relationships for Free Metal Ion Activities and Validation with Independent Data
Authors: Groenenberg J. E. , Roemkens P. F. A. M. , Comans R. N. J. , Luster J. , Pampura T. , Shotbolt L. , Tipping E. , De Vries W. 
Published: November 2010

AbstractReview: 70 refs.
Preimplant Left Ventricular End‐Diastolic Dimension and Body Weight Independently Associate With Paced QRS Duration in Patients Receiving Right Ventricular Apical Pacing for Complete Atrioventricular Block
Authors: Qiao Qing , Hua Wei , Zhang Shu 
Published: November 2010

AbstractBackground:Paced QRS duration, a good marker of ventricular asynchrony while pacing, has been accepted as a valuable predictor of new‐onset heart failure in patients receiving right ventricular apical pacing. But nowadays we have little evidence for predicting paced QRS duration before the implantation.Hypothesis:There might be relationships between paced QRS duration and demographic characteristics, clinical features such as comorbidities, native QRS duration, or preimplant cardiac size. The purpose of this article was to identify potential predictors of paced QRS duration in patients receiving right ventricular apical pacing for complete atrioventricular block.Methods:One hundred seventy patients with right ventricular apical pacing for complete atrioventricular block were divided into 2 groups according to whether the paced QRS duration was longer than 170 ms or not. Demographic characteristics, clinical features, electrocardiogram and echocardiography before implantation, and electrocardiogram immediately after implantation, were retrospectively recorded.Results:Preimplant left ventricular end‐diastolic dimension (LVEDD) and body weight were found to be independently associated with the paced QRS duration. Although both of them had low sensitivity and specificity in predicting paced QRS duration longer than 170 ms, the specificity could increase to 81.2% when they were combined.Conclusions:Both preimplant LVEDD and body weight independently associate with paced QRS duration in patients receiving apical pacing for complete atrioventricular block. Although whether they really have an effect on new‐onset heart failure still needs to be verified, and these findings might be a good indication. Copyright © 2010 Wiley Periodicals, Inc.The authors have no funding, financial relationships, or conflicts of interest to disclose.
Prediction of Long‐Term Survival in Chronic Heart Failure by Multiple Biomarker Assessment: A 15‐Year Prospective Follow‐Up Study
Authors: Volpe Massimo , Francia Pietro , Tocci Giuliano , Rubattu Speranza , Cangianiello Sara , Elena Rao Maria Assunta , Trimarco Bruno , Condorelli Mario 
Published: November 2010

AbstractBackground:In chronic heart failure (CHF), several plasma biomarkers identify subjects at risk of death over the midterm. However, their long‐term predictive value in the context of other candidate predictors has never been assessed. This information may prove valuable in the management of a chronic disease with a long natural history, as CHF is today.Hypothesis:We aimed to assess the very‐long‐term prognostic power of a set of biomarkers to identify CHF patients at highest risk for all‐cause mortality.Methods:A group of 106 consecutive outpatients with CHF (85 male and 21 female, median age 56 y) was followed for 15 years. Echocardiographic tracings and blood samples were collected at study entry to evaluate cardiac function, plasma atrial natriuretic peptide (ANP), aldosterone, and erythropoietin, and plasma renin activity. The relationships between biomarkers, clinical and echocardiographic variables, and mortality were assessed.Results:After 15 years, 86 of the 106 patients (81%) had died. Multivariate analysis showed that ANP was the best independent predictor of survival over several clinical, echocardiographic, and humoral variables (hazard ratio: 5.62, 95% confidence interval: 3.37–9.39, P < 0.001 for plasma levels < median value of 71 pg/mL). Plasma renin activity and erythropoietin provided prognostic information in univariate analysis, but lost their predictive power when adjusted for covariates.Conclusions:The present study represents the longest available follow‐up of patients with CHF evaluating the prognostic power of multiple biomarkers. It shows that a simple assessment of plasma ANP levels is the strongest long‐term predictor of death in all stages of heart failure. Copyright © 2010 Wiley Periodicals, Inc.This work was supported by a grant from MIUR 2001068248. The authors have no other funding, financial relationships, or conflicts of interest to disclose.
Soluble Receptors for Advanced Glycation End Products (sRAGE) as a Predictor of Restenosis Following Percutaneous Coronary Intervention
Authors: McNair Erick D. , Wells Calvin R. , Mabood Qureshi A. , Basran Rashpal , Pearce Colin , Orvold Jason , Devilliers Jacobus , Prasad Kailash 
Published: November 2010

AbstractBackground:Interaction of advanced glycation end products (AGEs) with their receptor (RAGE) increases expression of inflammatory mediators (tumor necrosis factor alpha [TNF‐α] and soluble vascular cell adhesion molecule‐1 [sVCAM‐1]) and induces oxygen radicals that are implicated in atherosclerosis. Balloon‐injury‐induced atherosclerosis is associated with increased expression of AGEs and RAGE. The soluble receptor for AGE (sRAGE), which acts as a decoy for RAGE ligands (AGEs), prevents atherosclerosis in this model.Hypothesis:We evaluated: 1) whether post‐percutaneous coronary intervention (PCI) restenosis is associated with low pre‐PCI serum sRAGE, high serum AGEs, TNF‐α, and sVCAM‐1, and high AGE/sRAGE ratio; 2) whether pre‐PCI and post‐PCI levels of these markers are similar in patients with or without restenosis; and 3) whether sRAGE and AGE/sRAGE ratio have predictive value for post‐PCI restenosis.Methods:Angiography was performed in 46 patients with non–ST‐segment elevation myocardial infarction for assessment of restenosis. Serum sRAGE, AGEs, TNF‐α, and sVCAM‐1 were measured in these patients and 20 control subjects.Results:Nineteen of the 46 patients developed post‐PCI restenosis, which was associated with lower sRAGE and higher TNF‐α and sVCAM‐1 levels, and higher AGE/sRAGE ratio compared with patients without restenosis. Pre‐PCI and post‐PCI levels of these biomarkers were similar in both groups, except in patients with restenosis, in whom the post‐PCI level of sRAGE was lower and TNF‐α was higher than the pre‐PCI levels. The sensitivity and negative predictive value of sRAGE were 100%, and were higher than those of AGE/sRAGE ratio in identifying post‐PCI restenosis.Conclusions:Both low serum sRAGE levels and high AGE/sRAGE ratio have predictive value for post‐PCI restenosis. Copyright © 2008 Wiley Periodicals, Inc.This research was supported by grants from the Heart and Stroke Foundation of Saskatchewan and the Pollack Research Foundation, Saskatoon, Saskatchewan. The authors have no other funding, financial relationships, or conflicts of interest to disclose.
Is Calcium Scoring of the Coronary Arteries Necessary for Proper Management of Asymptomatic Subjects With Classic Risk Factors?
Authors: Richard Conti C. 
Published: November 2010

Abstractmagnified image In 2000, I wrote an editorial entitled, “Detecting Coronary Calcium.”1 For the past several years there have been numerous publications on this subject. Recently, an article by Min et al, provided some important information about patients with a normal coronary calcium scan and the conversion from a zero calcium score to greater than zero.2 Copyright © 2010 Wiley Periodicals, Inc.
Nuclear localization of Nm23‐H1 in head and neck squamous cell carcinoma is associated with radiation resistance
Authors: Park Haeng Ran , Kim Se‐Heon , Lee Sei Young , Sung Ji Min , Park Ae Ran , Kang Suki , Kim Baek Gil , Choi Yoon Pyo , Kim Yong‐Bae , Cho Nam Hoon 
Published: November 2010

AbstractBACKGROUND:Although radiation resistance is a primary issue in radiation therapy, attempts to find predictors of radiation resistance have met with little success. The authors therefore aimed to determine predictors for radiation resistance to improve the prognosis of head and neck squamous cell carcinoma (HNSCC).METHODS:HNSCC cell lines, SCC15, SCC25, and QLL1, irradiated with an acute dose of 4 grays (Gy) (RR‐4), a cumulative dose of 60 Gy (RR‐60), and a booster dose of 4 Gy over 60 Gy (RR‐60 + 4), were used with nonirradiated cell lines. Those were used in cDNA microarray, proteomics, Western blotting, and immunofluorescence, respectively. One hundred five HNSCC tissue samples with radiation resistance were analyzed by immunohistochemistry.RESULTS:Western blot analysis of RR‐60 cell lines was identical to the data of Nm23‐H1 overexpression by cDNA array and proteomic screening. Immunofluorescence demonstrated significant nuclear translocation of Nm23‐H1 in RR‐4 and RR‐60 cell lines, and less but still intense nuclear shuttling in RR‐60 + 4. Similarly, Nm23‐H1 nuclear localization was observed in 20% (21 of 105) of tissue samples. Univariate analysis demonstrated that Nm23‐H1 nuclear localization was strongly associated with overall and recurrence‐free survival. Multivariate stepwise Cox regression analysis showed that Nm23‐H1 nuclear localization (odds ratio [OR], 7.48) and N stage (OR, 2.13) were associated with overall survival, and Nm23‐H1 nuclear localization (OR, 3.02), T stage (OR, 1.43), and insufficient tumor margin (OR, 3.27) were associated with recurrence‐free survival.CONCLUSIONS:Overexpression of Nm23‐H1, specifically its nuclear translocation, may be a powerful predictor of radiation resistance in HNSCC. Cancer 2011. © 2010 American Cancer Society.
Crystal growth and electric‐property change by rubidium or cesium doping on potassium‐sodium‐niobate
Authors: Kimura Hideo , Tanahashi Rumi , Zhao Hongyang , Maiwa Koji 
Published: November 2010

AbstractAlkali metals (Na, Rb or Cs) co‐doped with fiber‐ and bulk‐shaped KNbO3 single crystals were grown using two original methods by means of doping together of small ionic Na and large ionic Rb or Cs into KNbO3. Single‐phase crystals could be grown with an orthorhombic system at room temperature as well as pure KNbO3. Piezoelectric and ferroelectric property changes by the co‐doping of Rb or Cs with Na were estimated using d33 values and a polarization‐electric field hysteresis curve in fiber‐ and bulk‐shaped crystals. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Chemistry by Nanocatalysis: First Example of a Solid‐Supported RAPTA Complex for Organic Reactions in Aqueous Medium
Authors: García‐Garrido Sergio E. , Francos Javier , Cadierno Victorio , Basset Jean‐Marie , Polshettiwar Vivek 
Published: November 2010

AbstractA ruthenium–arene–PTA (RAPTA) complex has been supported for the first time on an inorganic solid, that is, silica‐coated ferrite nanoparticles. The resulting magnetic material proved to be a general, very efficient and easily reusable catalyst for three synthetically useful organic transformations; selective nitrile hydration, redox isomerization of allylic alcohols, and heteroannulation of (Z)‐enynols. The use of low metal concentration, environmentally friendly water as a reaction medium, with no use at all of organic solvent during or after the reactions, and microwaves as an alternative energy source renders the synthetic processes reported herein “truly” green and sustainable.
CeIV‐ and Light‐Driven Water Oxidation by [Ru(terpy)(pic)3]2+ Analogues: Catalytic and Mechanistic Studies
Authors: Duan Lele , Xu Yunhua , Tong Lianpeng , Sun Licheng 
Published: November 2010

AbstractA series of mononuclear ruthenium polypyridyl complexes [Ru(Mebimpy)(pic)3](PF6)2 (2; Mebimpy=2,6‐bis(1‐methylbenzimidazol‐2‐yl)pyridine; pic=4‐picoline), Ru(bimpy)(pic)3 (3; H2bimpy=2,6‐bis(benzimidazol‐2‐yl)pyridine), trans‐[Ru(terpy)(pic)2Cl](PF6) (4; terpy=2,2′;6′,2“‐terpyridine), and trans‐[Ru(terpy)(pic)2(OH2)](ClO4)2 (5) are synthesized and characterized as analogues of the known Ru complex, [Ru(terpy)(pic)3](PF6)2 (1). The effect of the ligands on electronic and catalytic properties is studied and discussed. The negatively charged ligand, bimpy2−, has a remarkable influence on the electrochemical events due to its strong electron‐donating ability. The performance in light‐ and CeIV‐driven (CeIV=Ce(NH4)2(NO3)6) water oxidation is successfully demonstrated. We propose that ligand exchange between pic and H2O occurs to form the real catalyst, a Ru–aqua complex. The synthesis and testing of trans‐[Ru(terpy)(pic)2(OH2)](ClO4)2 (5) confirmed our proposal. In addition, complex 5 possesses the best catalytic activity among these five complexes.
A cross‐species analysis of Satb2 expression suggests deep conservation across vertebrate lineages
Authors: Sheehan‐Rooney Kelly , Pálinkášová Božena , Eberhart Johann K. , Dixon Michael J. 
Published: November 2010

AbstractMutation of SATB2 causes cleft palate in humans. To understand the role of SATB2 function in palatogenesis, SATB2 analyses in vertebrate model systems will be essential. To facilitate these analyses, we have performed a cross‐species comparison of SATB2 structure and function across three vertebrate model systems: mouse, chick, and zebrafish. We find that the SATB2 transcript is highly conserved across human, mouse, chick, and zebrafish, especially within the Satb2 functional domains. Furthermore, our expression analyses demonstrate that SATB2 is likely to have similar functions in vertebrate model organisms and humans during development of the facial processes and secondary palate. Together, these data suggest an evolutionary conserved role for SATB2 during development of the face and palate across vertebrates. Moreover, expression of zebrafish satb2 in the anterior neurocranium supports the utility of the anterior neurocranium as a simplified model of amniote palatogenesis. Developmental Dynamics 239:3481–3491, 2010. © 2010 Wiley‐Liss, Inc.
ASSET: A robust algorithm for the automated segmentation and standardization of early Caenorhabditis elegans embryos
Authors: Blanchoud Simon , Budirahardja Yemima , Naef Félix , Gönczy Pierre 
Published: November 2010

AbstractThe early Caenorhabditis elegans embryo is an attractive model to investigate evolutionarily conserved cellular mechanisms. However, there is a paucity of automated methods to gather quantitative information with subcellular precision in this system. We developed ASSET (Algorithm for the Segmentation and the Standardization of C. elegans Time‐lapse recordings) to fill this need. ASSET automatically detects the eggshell and the cell cortex from DIC time‐lapse recordings of live one‐cell‐stage embryos and can also track subcellular structures using fluorescent time‐lapse microscopy. Importantly, ASSET standardizes the data into an absolute coordinate system to allow robust quantitative comparisons between embryos. We illustrate how ASSET can efficiently gather quantitative data on the motion of centrosomes and precisely track cortical invaginations, revealing hitherto unnoticed differences between wild‐type and saps‐1(RNAi) embryos. In summary, we establish ASSET as a novel tool for the efficient quantification and standardization of images from early C. elegans embryos. Developmental Dynamics 239:3285–3296, 2011. © 2010 Wiley‐Liss, Inc.
Heptaphosphanortricyclenes with Oligosilyl Substituents: Syntheses and Reactions
Authors: Noblet Pierre , Cappello Vittorio , Tekautz Günter , Baumgartner Judith , Hassler Karl 
Published: November 2010

AbstractThree new nortricyclic P7R3 derivatives with R = (SiMe3)2MeSi– (2), (SiMe3)2PhSi– (3), and cyclo‐Si6Me11– (4) were synthesized from red phosphorus, sodium/potassium alloy, and a chlorooligosilane, and their structures were elucidated with X‐ray diffraction. Reactions of 2 and 3 and of tri(hypersilyl)heptaphosphane 1 [hypersilyl = (SiMe3)3Si–] with KOtBu and LiOtBu were performed, which led to different results depending on the size of the substituent. With KOtBu, Si–P bonds were cleaved in 2 and 3, and the mono‐ and dianions [P7R2]– [R = (SiMe3)2MeSi: 2a; R = (SiMe3)2PhSi: 3a] and [P7R]2– [R = (SiMe3)2MeSi: 2b] formed. Crystals of the [K+.18‐crown‐6]+ salt of 2b suitable for X‐ray diffraction could be grown successfully. Compound 1 reacted in an unprecedented way with KOtBu at –60 °C. An Si–Si bond was cleaved, and a transient silyl anion formed, which immediately rearranged into a transient heptaphosphanide anion [Hyp2P7]– (1a) under expulsion of bis(trimethylsilyl)silylene. The silylene immediately inserted into a P–P bond of the basal P3 ring of 1a, thereby forming two new isomeric anions {Hyp2P7[Si(SiMe3)2]}–, 1b and 1c. The structure of 1c could be elucidated by X‐ray crystallography, whereas 1b was characterized by 31P NMR spectroscopy. The proposed reaction mechanism could be further confirmed by performing the reaction between 1 and KOtBu in the presence of a large excess amount of dimethylbutadiene, which trapped the silylene. Just the formation of anion 1a was observed in that case. Anion 1a was also obtained quantitatively when KOtBu was replaced by LiOtBu. Compound 1a reacted with trifluoroacetic acid to give Hyp2P7H (1d), which was successfully crystallized and examined by X‐ray diffraction. It is the first structural example of a stable and neutral nortricyclic P7 derivative, R2P7H. All compounds were chracterized further by 31P and 29Si NMR spectroscopy and elemental analyses.
High‐Temperature Synthesis and Formation Mechanism of Stable, Ordered MCM‐41 Silicas by Using Surfactant Cetyltrimethylammonium Tosylate as Template
Authors: Zhang Kun , Chen Hong‐Li , Albela Belén , Jiang Jin‐Gang , Wang Yi‐Meng , He Ming‐Yuan , Bonneviot Laurent 
Published: November 2010

AbstractHighly ordered 2D hexagonal mesostructured silicas with thick pore walls have been directly hydrothermally synthesized at high temperatures in a range from 130 to 175 °C by using the new surfactant cetyltrimethylammonium tosylate (CTATos) as template. The mesoporous structure of the synthesized MCM‐41 could be maintained after heating it to reflux in boiling water for at least 24 h. The crystallization temperature, the nature of surfactants, and the relative amount of TAAOH (tetraalkylammonium hydroxide, such as TMAOH and TEAOH) to surfactant were found to be critical parameters that affect the ordering of mesophases. On the basis of the combined characterizations of X‐ray diffraction (XRD), N2 adsorption, Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TG), 13C cross‐polarization magic‐angle spinning (CPMAS) solid‐state NMR spectroscopy, transmission electron microscopy (TEM) and scanning electron microscopy (SEM), a new mechanism was proposed to understand the formation mechanism of highly ordered MCM‐41 silicas. The enlargement of pore‐wall thickness is attributed to the migration and subsequent deposition of the silicate species in the inner pore channel. This process was accelerated by the ion‐exchange interaction of tetraalkylammonium cations (TAA+) on CTA+ cations.
Use of hybrid organic‐siliceous catalysts for the selective conversion of glycerol
Authors: Jérôme François , Barrault Joël 
Published: November 2010

AbstractThe contribution of hybrid organic‐siliceous materials for the selective conversion of glycerol is discussed. Through selected examples, we wish to show that the easy functionalization of siliceous supports with organic moiety, their large pore opening and the high hydrophilicity of these materials can be a great tool for the selective use of glycerol as a naturally sourced organic building block in organic chemistry. In particular, we show that hybrid organic‐siliceous materials are highly efficient for the direct and selective monofunctionalization of glycerol under mild conditions, thus offering a very convenient route to a wide range of chemicals such as monoglycerides, glycerol ethers, or renewably sourced monomers which are usually obtained with low yields using conventional catalytic routes. The glycerol industrially produced by the biodiesel manufacture is called glycerin and is an average mixture of glycerol (80 wt%), water (15 wt%), and soap (5 wt%). The possible utilization of glycerin instead of refined glycerol is much more desirable from the viewpoint of green chemistry but the presence of water and/or soap causes important damages to solid catalysts. In this context, we show here that the recent progresses in the search of water‐tolerant silica‐based materials now offers great means to directly use glycerin instead of refined glycerol as building block.
Synthesis of BODIPY‐Appended Subporphyrins
Authors: Sugimoto Hisashi , Muto Masahiro , Tanaka Takayuki , Osuka Atsuhiro 
Published: November 2010

AbstractBODIPY–subporphyrin hybrids bridged by a 1,4‐biphenylene or 1,4‐diphenylethynylene spacer were synthesized either by the palladium‐catalyzed Suzuki–Miyaura reaction or the Sonogashira reaction. Their structural and optical properties were examined with respect to the bridge and BODIPY structures. In all cases, intramolecular excitationenergy transfer from the subporphyrin core to the BODIPY peripheries is efficient. Depending on the presence or absence of β‐methyl groups adjacent to the meso position of the BODIPY subunit, the fluorescence is either increased or decreased. It was also found that the electronic interaction between the subporphyrin core and the meso‐(1,4‐phenylene) substituents causes spectral changes for the subporphyrin part, which is not observed for porphyrin counterparts.