bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacoeconomics and wound care. When therapeutic appropiateness and cost savings move in the same direction
Authors: Filoso Immacolata , Citro Ivana , Iacolare Maria Rosaria , Monti Ida , Quinto Nunzio , Russo Giacomo , Tortora Attilio , Falconio Lucio Marcello 
Published: April 2024

In the year 2019, 121 patients were admitted to the Casavatore Hospice. All patients, upon admission, exhibited pressure ulcers (Ldp) in both stages I and II. A portion of the patients with stage II ulcers were treated with advanced dressings containing micronized silver (20 patients), resulting in a regression of the ulcer to stage I. Subsequently, they were treated with topical application of silver sulfadiazine cream until complete healing of the lesion. Patients who did not have favorable indications for the application of such treatment were treated with Sofargen cream (60 patients), nonetheless preventing the worsening of the stage of the pressure ulcer. Patients with stage I ulcers (41 patients) were treated daily with silver sulfadiazine spray, which still contributed to the prevention of secondary lesions associated with immobility.
The objective of managing pressure ulcers in bedridden or terminal patients has been fully achieved within dignified care times and, above all, with reduced company costs.
As a final result, considering the current prices for both dressings and the specific drug, we achieved an economic savings exceeding 35%, highlighting how it is possible to implement, in various aspects and situations, important yet simple care approaches while respecting therapeutic appropriateness and patient compliance.
Apakah IPM, Tingkat Urbanisasi dan Pertumbuhan Ekonomi Mempengaruhi Kemiskinan di Provinsi Jawa Timur ?
Authors: Noya Avior Ocean , Muchtar Masruri , Sihombing Pardomuan Robinson 
Published: April 2024

Penelitian ini bertujuan untuk mengetahui seberapa besar pengaruh tingkat urbanisasi, IPM dan pertumbuhan ekonomi terhadap tingkat kemiskinan di Provinsi Jawa Timur. Variabel dependen yang digunakan dalam penelitian ini adalah tingkat kemiskinan, sedangkan variabel independen yaitu urbanisasi, indeks pembangunan manusia dan pertumbuhan ekonomi. Penelitian menggunakan data sekunder kabupaten/kota yang ada di Provinsi Jawa Timur dalam rentang waktu 9 tahun dari 2012 hingga 2020. Metode statistik yang digunakan adalah metode kuantitatif dengan regresi linier berganda dengan data panel. Berdasarkan pengujian, digunakan Fixed Effect Model. Secara simultan seluruh variabel berpengaruh terhadap kemiskinan. Secara parsial, ketiga variabel berpengaruh signifikan negatif terhadap kemiskinan. Berdasarkan hasil penelitian ini, pemerintah diharapkan tidak hanya berfokus pada pertumbuhan ekonomi namun juga pengendalian tingkat urbanisasi dan peningkatan IPM.
Peran Badan Pendapatan Daerah dalam Meningkatkan Penerimaan Pajak Bumi dan Bangunan di Kabupaten Bengkulu Utara
Authors: Aldo Ahmad , Adriadi Rekho , Yogi Alfiansyah  , Darmi Titi 
Published: April 2024

Penelitian ini bertujuan untuk mengetahui tentang PeranBadan Pendapatan Daerah Dalam Meningkatkan Penerimaan Pajak Bumi Bangunan Di Kabupaten Bengkulu Utara. Dalam penelitian ini peran Badan Pendapatan Daerah dalammenigkatkan penerimaan pajak bumi bangunan yaitu sebagai motivator,fasilitator, dan mobilisator. Penelitian ini menggunakan metode kualitatif. Teknik pengumpulan data dengan observasi, wawancara dan dokumentasi. Data-data di dalam penelitian ini menggunakan triangulasi sumber. Teknik analisis data dalam penelitian ini menggunakan analisis data kualitatif. Hasil penelitian ini menunjukan bahwa dari Indikator Motivator, Fasilitator, dan Mobilisator yang digunakan dalam penelitian ini menunjukan bahwa Peran Bapenda Dalam Meningkatkan Penerimaan Pajak Bumi dan Bangunan di Kabupaten Bengkulu Utara sudah berjalan dengan baik, Namun masih rendahnya penerimaan Pajak Bumi dan Bangunan di Kabupaten Bengkulu Utara dikarenakan masih kurangnya kesadaran masyarakat untuk membayar pajak sehingga Bapenda perlu meningkatkan penyuluhan tentang pentingnya Pajak Bumi dan Bangunan di Desa maupun Kecamatan.
Iklim Organisasi Dan Kepuasan Kerja Pegawai Pengadilan Agama Denpasar
Authors: Muhammad H.A.Rahman Abdul halim , Nyoman Sri Subawa  
Published: April 2024

The Denpasar Religious Court is the only Class I Religious Court in the province of Bali. As a Class I Religious Court, it handles a lot of cases per year, with an insufficient number of employees leading to an increased workload for the staff. Alongside the implementation of the "one day minute and one day publish" program, the Denpasar Religious Court also acts as a coordinator for budget absorption related to DIPA 04, overseeing eight Class II Courts. Furthermore, the less strategic location of the Denpasar Religious Court, due to its off-road placement, makes it challenging for parts of the community to locate the court.
The main issue addressed in this study is how the organizational climate and employee job satisfaction at the Denpasar Religious Court are. The objectives of this research are: 1) to examine the organizational climate at the Denpasar Religious Court, and 2) to determine the influence of the organizational climate at the Denpasar Religious Court on employee job satisfaction. The research method utilized in this study is a qualitative approach with thematic analysis.
The research findings indicate that: 1) the organizational climate at the Denpasar Religious Court, characterized by supportive leadership, has the strongest influence, along with teamwork and communication; and 2) the organizational climate significantly affects job satisfaction, where motivation, employee commitment, and efficiency are the variables that impact job satisfaction
Penerapan Kebijakan penggunaan Angkutan Feeder LRT Musi di Kota Palembang Tahun 2022
Authors: Ismi Pratama Muhammad Dani , Kencana Novia , Isabella Isabella 
Published: April 2024

Penelitian ini bertujuan untuk mengetahui Bagaimana Penerapan Kebijakan dalam Penggunaan Angkutan Feeder LRT Di Kota Palembang Tahun 2022. Penelitian ini menggunakan metode kualitatif, dimana metode ini adalah metode penelitian kualitatif ini dapat menyajikan data yang tidak monoton dan membosankan dan tidak terpaku pada satu titik, dari indikator-indikator teori yang akan dipakai inilah dapat peneliti kembangkan sehingga mendapatkan hasil yang ingin di capai nantinya. Hasil penelitian menunjukkan bahwa program ini dinilai cukup baik dengan melakukan wawancara mendalam, dan melakukan observasi ke kegiatan tersebut dengan berpedoman dengan indikator Yaitu (1) Isi Kebijakan (Content of Policy) dan (2) Lingkungan Implementasi (Context of Implementation). Melalui serangkaian penelitian, analisis dan pembahasan yang di lakukan, peneliti mengambil kesimpulan jika, dapat diambil kesimpulan bahwa penggunaan Angkutan Feeder LRT ini sudah Cukup baik, jika dilihat dari 2 Indikator tersebut, Karana Angkutan ini masih memiliki beberapa kekurangan seperti masih sepi pengunjung dan tidak ada jadwal keberangkatan di setiap halte.
A importância dos índices antropométricos na prevenção de risco cardiovascular
Authors: Fiamoncini Tigre Inaê Luana , De Jesus dos Santos Dayane , Guedes Romeiro Clara Maria , Santos Souza Almeida Fabyanne , Monteiro da Cruz Cristiane 
Published: April 2024

Os indicadores antropométricos são os índices da aferição do peso, altura, dobras cutâneas, circunferência abdominal (CA), índice de conicidade (IC), razão cintura-estatura (RCEst), circunferência da cintura (CC), circunferência do quadril (CQ), relação cintura-quadril (RCQ) e o índice de massa corporal (IMC), por exemplo. Nesse sentido, estudos anteriores têm relatado diferentes níveis de eficácia dessas medidas na identificação do risco de doenças cardiovasculares. Este artigo é uma revisão sistemática que visa analisar os índices antropométricos como prevenção de risco cardiovascular. As buscas foram realizadas, até fevereiro de 2024, em duas bases de dados: PubMed e BVS, usando os seguintes descritores: “Heart Disease Risk Factors” ; “anthropometric indices” ; “coronary heart disease” e “abdominal circumference”. Observa-se que foram selecionados artigos que se evidenciaram relevantes para o tema proposto. Portanto, conclui-se que tais indicadores representam um conjunto de métodos de baixa complexidade e baixo custo, amplamente utilizados em estudos epidemiológicos e que estão associados com a avaliação de doenças cardiometabólicas.
Abordagem Terapêutica da Síndrome de Sjögren: uma revisão narrativa
Authors: Salgado Oliveira Raphaella , Leite Costa Adriel , Aemi Ohfugi Danielly , Miyuki Nishi de Castro Francine , Lucas Foltran Gustavo , Braz Gomes Vitoriano Larissa , de Figueiredo Andrade Júnior Márcio , Guimarães dos Santos Natália , Mitsuo Kakinoki Nomoto Nilton , Vasconcelos do Vale Aguiar Andrezza 
Published: April 2024

Objetivo: Informar sobre o estado atual das evidências sobre a eficácia e segurança dos principais tipos de terapias aplicadas à Síndrome de Sjögren (SS). Revisão Bibliográfica: Atualmente não existe nenhuma substância curativa para a SS, sendo o objetivo terapêutico a melhora sintomática, a prevenção de danos sistêmicos e a melhora na qualidade de vida. Existem as terapias tópicas orais e oftalmológicas cujo objetivo é melhorar os sintomas da xerostomia e xeroftalmia, conhecidos como síndrome sicca. Sobre as terapias farmacológicas orais na SS, o foco principal é suprimir a atividade imune anormal em pacientes críticos. Quando o dano visceral está presente e grave, a terapia com glicocorticoides é utilizada além dos agentes imunossupressores como a hidroxicloroquina, metotrexato, rituximabe e os inibidores do fator de necrose tumoral. Conclusão: Observou-se uma grande divergência no uso dessas drogas, por isso, existem poucas recomendações oficiais no uso da terapia farmacológica, fazendo com que muitas escolhas terapêuticas sejam baseadas na prática clínica. Assim, conclui-se que é necessário mais estudos para apoiar a decisão dos especialistas, bem como identificar aqueles pacientes que apresentarão mais benefícios com uma determinada terapia.
Geisterhände – neu belebt
Authors: Bausch Sebastian , Bärtsch Manuel 
Published: April 2024

Since more than 15 years, the Bern University of the Arts (HKB) has been researching early 20th century piano and organ rolls. In the SNF‑AGORA‑Project "Magic Piano", researchers are seeking ways to make the recordings and related insights accessible to a larger public through the website www.magic-piano.ch.
Adverse drug events among hospitalized COVID-19 patients. Experience with the Global Trigger Tool
Authors: Mishinova S. A. , Kolbin A. S. , Verbitskaya E. V. , Alekseeva N. P. , Gomon Yu. M. 
Published: April 2024

The Global Trigger Tool is a reliable method for detecting adverse events, demonstrating positive predictive value and significant sensitivity among patients with COVID-19.The objective of this study was to develop and apply an adapted Global Trigger Tool to identify potential adverse events among hospitalized patients with moderate to severe COVID-19.Materials and methods. The study included a literature review, analysis of spontaneous reports n=873 in the national database of the Russian Federation for the COVID-19 indication for the period 2020–2022, and application of the trigger tool in a single-center retrospective study n=329. Statistical processing was performed by the method of disproportionality with the determination of the odds ratio of reporting. The symptom-syndrome method based on parameterization of interaction effects using Zhegalkin polynomials was used to identify significant effects of drug associations; Fisher’s exact test was used to select the most significant associations for occurrence.Results. Among the triggers with a frequency of 10 or higher in terms of mortality rate (≥80%), the leading ones were: pulmonary edema, hypotension, and respiratory failure, which is consistent with the COVID-19 clinical course of the disease. A disproportionately high incidence of respiratory failure was associated with favipiravir use. Leukocytosis associated with tofacitinib use and drug-induced liver damage associated with tocilizumab use.Conclusions. The identified potential adverse events and their associated mortality risks among patients with moderate to severe COVID-19 allow for compliance with current clinical guidelines for the management of patients with COVID-19.
Relationship between renal damage marker levels and the presence of bleeding in patients with atrial fibrillation and chronic kidney disease receiving rivaroxaban
Authors: Shatalova N. A. , Ostroumova O. D. , Korotkova T. N. , Vorozhko I. V. , Klychnikova E. V. , Ebzeeva E. Yu. , Godkov M. A. , Starodubova A. V. , Mirzaev K. B. , Sychev D. A. 
Published: April 2024

Relevance. Chronic kidney disease (CKD) is often concomitant pathology in patients with atrial fibrillation (AF). Because of the increased risk of bleeding in patients with AF and CKD while taking anticoagulant therapy, it is necessary to assess new methods for predicting the risk of bleeding when prescribing anticoagulants in this category of patients.Objective. To evaluate the possible relationship between the presence of bleeding in patients with AF and CKD C3–4 receiving rivaroxaban and the level of renal damage markers in urine.Methods. One hundred and thirty-three patients with AF and CKD C3a-C4 aged 52 to 97 years (median age 82 [74;86] years) were included in the study. All patients were assessed for bleeding and excretion of markers of renal damage (albumin; nephrin; neutrophil gelatinase-associated lipocalin (NGAL), and kidney injury molecule-1 (KIM-1)) in with urine have been identified. In addition, the levels of kidney injury markers in the urine of 45 healthy volunteers were analyzed.Results. Urinary NGAL and KIM-1 levels in patients with AF and CKD with a history of bleeding (5.5 [3.81;23.83] ng/ml and 0.68 [0.27;1.10] ng/ml, respectively) were significantly higher than those in patients without bleeding (4.19 [2.22; 15.53] ng/ml, p=0.039, and 0.38 [0.13;0.66] ng/ml, p=0.019, respectively) and healthy subjects (2.6 [1.9;4.3] ng/ml, p<0.001, and 0.21 [0.10;0.69], p=0.003, respectively).Conclusion. Patients with AF and CKD C3a — C4 on rivaroxaban treatment with a history of bleeding have higher urinary excretion of KIM-1 and NGAL.
Ideal recruitment rate in clinical trials in phases II–III
Authors: Milovanov S. S. 
Published: April 2024

Actuality. The speed of patient recruitment into a clinical trial allows us to evaluate the work of the clinical center and calculate the time required to achieve targeted recruitment. The authors estimate the recruitment rate on the basis of comparison with the target recruitment value, and according to the literature, the recruitment rate is influenced by many factors, which mainly have a negative effect, reducing it. Assessments of the optimality of recruitment or the normality of recruitment of patients according to the literature were always made based on a specific protocol and nosology because this parameter cannot be constructed experimentally under ideal conditions in the absence of the influence of one or another factor. On the other hand, most clinical trials fail to recruit patients, and accordingly, the recruitment rate in such studies was strongly influenced by certain factors. For the first time, we assessed the patient recruitment rate in successful studies when calculating the degree of influence of the nosology and found the ideal recruitment rate, i. e., the recruitment rate with zero influence of the factor.Objective. To quantify the degree of influence of the nosology factor of the protocol on the recruitment rate of patients in a clinical trial.Materials and methods. A retrospective analysis of 4 international multicenter clinical trials of II–III phases was conducted on the recruitment of patients depending on the influence of the nosology factor of the protocol. Descriptive statistics using the typing and odds ratio technique.Results and discussion. A quantitative assessment of the influence of the nosology factor of the protocol on the rate of patient recruitment was obtained. Found the ideal typing speed.Conclusions. For the first time, a quantitative assessment of factors influencing patient recruitment has been proposed. For the first time, the ideal recruitment rate has been determined.
Marketing analysis of the Russian pharmaceutical market of oxaliplatin
Authors: Gopienko I. A. , Zyryanov S. K. 
Published: April 2024

Relevance. Colon and ovarian cancer occupy leading positions in the structure of morbidity and mortality among malignant neoplasms in Russia. One of the widely used drugs for the treatment of these nosologies is oxaliplatin, but there is no relevant information to assess its availability and share among other antitumor drugs.Objective. Analysis of the Russian pharmaceutical market for oxaliplatin drugs among other antitumor drugs in 2015–2022.Materials and methods. For the analysis, reports from marketing agencies DSM Group and IMS were used, both in value and in physical terms.Results. During the period under study, significant changes occurred in the Russian pharmaceutical market of antitumor drugs: the volume of sales and consumption increased, which was also accompanied by a decrease in the cost of drug units per package (all antitumor drugs) and course of use (oxaliplatin). At the same time, the share of Russian manufacturers of antitumor drugs has increased. In relation to oxaliplatin, during the study period there was almost complete displacement of the original drug from the market by generic drugs. An intensive process of import substitution was also observed: the share of domestic drugs increased by the end of the study period in value and volume terms to 93 and 95%, respectively.Conclusion. Identified changes in the Russian pharmacological market for 2015–2022 reflect an increase accompanied by an increase in the availability of antitumor drugs and, in particular, oxaliplatin.
Current issues of increasing the availability of innovative therapy for the treatment of patients with non-small cell lung cancer within the Russian healthcare system
Authors: Laktionov K. K. , Zyryanov S. K. , Artamonova E. V. , Smolin A. V. , Reutova E. V. , Zhuravleva M. V. , Kolbin A. S. , Frolov M. Yu. 
Published: April 2024

The advisory board was held to discuss he current situation with diagnosis and treatment of advanced non — small cell lung cancer with a mutation in the MET gene (aNSCLC with METex14). Lung cancer takes a leading place in the structure of oncological diseases in Russia. The frequency of molecular abnormalities in the MET gene patients with advanced lung cancer is 3%, the NGS method is the most effective in identifying this alteration.The effectiveness of capmatinib, a MET tyrosine kinase inhibitor was confirmed in the GEOMETRY mono-1 registry trial: the objective response rate in the patients with aNSCLC with METex14 who had previously received 1–2 lines of therapy was 41%, among those who had not previously received treatment — 68%. Median duration of response was 9.7 month in previously treated patients with aNSCLC with METex14 and 12.6 months in the treatment — naïve patients with aNSCLC with METex14. Intracranial response was observed in 54% of cases among patients with aNSCLC with METex14. In addition, the efficacy of capmatinib was confirmed when it is administered to the patients with aNSCLC with METex14 in real-world clinical practice. Other therapeutic options (immune-oncology therapy, chemotherapy) are less effective in case of this disease variant.Based on the data on effectiveness and tolerability of capmatinib, the expert group made a decision to recommend inclusion of capmatinib in the Russian Clinical Guidelines for the treatment of lung cancer and into the Essential Drug list.
Circadian marker in duodenal ulcer
Authors: Esedov E. M. , Musaeva L. N. 
Published: April 2024

The purpose. To study the content of melatonin in venous blood, to assess the seasonal variability of the hormone in patients with duodenal ulcer (DU) and to establish a possible relationship between the studied parameters.Material and methods. 45 patients with varying clinical activity of DU during exacerbation and during treatment were examined. Determination of melatonin in venous blood was carried out using high-performance liquid chromatography with tandem mass spectrometry. To assess the condition of the duodenum, fibrogastroduodenoscopy of the gastroduodenal zone we used Exera (cIF160) and Olympus endoscopes.Results. It has been established that in the active stage of DU the levels of the hormone melatonin are reduced. In order to study the possible effect of light illumination on melatonin content, we studied the production of this indole in groups of patients with DU at different times of the year. It turned out that the melatonin content was significantly lower in the group of patients with peptic ulcer disease in winter and spring.Conclusion. The regression and correlation analysis carried out revealed a positive moderate dependence of the melatonin indicator on the duration of daylight hours in the venous blood. Clinical remission of DU after 2 months was accompanied by an increase in melatonin production.
DETERMINATS OF PATIENT SATISFACTION IN MEDICINE COLLECTION SERVICES AT PHARMACEUTICAL INSTALLATION BANDA RAYA HEALTH CENTER IN BANDA ACEH
Authors: Putra Utama Anugerah Akbar , Arbi Anwar , Lina Intan 
Published: April 2024

Background: The Banda Raya Health Center (Puskesmas), reports that the number of patients who purchase medicines from the pharmacy at the Community Health Center Installation is decreasing every year, this is thought to be because the medicines needed are not available at the pharmacy. Patients who do not want to queues for a long time and prefer to buy medicines from the outside of the health center. Convenience and poor service procedures are also the reasons why patients feel dissatisfied with medication collection services. This study aims to determine patient satisfaction in medicine collection services at the the Banda Raya Community Health Center Pharmacy Installation, Banda Aceh City. Method: Quantitative research with cross sectional design. The sample in this study were patients/families of patients who purchase medication at the Banda Raya Health Center Pharmacy Installation, totaling 49 patients from January to March 2020, using the Accidental Sampling technique. This research was conducted on August 3-11, 2020. Bivariate analysis used SPSS with the chi square statistical test. Results: Univariate analysis showed that 69.4% of patients were dissatisfied, 75.5% were uncomfortable, 67.3% had a negative attitude, 73.5% had poor human relations, 75.5% had poor service procedures, and 77.5 % no drug availability. The results of the bivariate analysis showed that there was a relationship between comfort (P value = 0.004), attitude (P value = 0.002), human relations (P value = 0.001), service procedures (P value = 0.001), and drug availability (P value = 0.021 ) with patient satisfaction in drug collection services at the Pharmacy Installation of the Banda Raya Health Center, Banda Aceh City. Conclusion: Puskesmas are expected to be able to provide sufficient medicine and provide training for pharmaceutical service staff regarding good health service training such as carrying out the ‘3 S’ (Greet, Smile, Care) so that patients feel satisfied and comfortable.