bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of within-meal protein content and taste on subsequent food choice and satiety
Authors: Griffioen-Roose Sanne , Mars Monica , Finlayson Graham , Blundell John E. , de Graaf Cees 
Published: May 2011

It is posed that protein intake is tightly regulated by the human body. The role of sensory qualities in the satiating effects of protein, however, requires further clarification. Our objective was to determine the effect of within-meal protein content and taste on subsequent food choice and satiety. We used a cross-over design whereby sixty healthy, unrestrained subjects (twenty-three males and thirty-seven females) with a mean age of 20·8 (sd 2·1) years and a mean BMI of 21·5 (sd 1·6) kg/m2 were offered one of four isoenergetic preloads (rice meal) for lunch: two low in protein (about 7 % energy derived from protein) and two high in protein (about 25 % energy from protein). Both had a sweet and savoury version. At 30 min after preload consumption, subjects were offered an ad libitum buffet, consisting of food products differing in protein content (low/high) and taste (sweet/savoury). In addition, the computerised Leeds Food Preference Questionnaire (LFPQ) was run to assess several components of food reward. The results showed no effect of protein content of the preloads on subsequent food choice. There was an effect of taste; after eating the savoury preloads, choice and intake of sweet products were higher than of savoury products. No such preference was seen after the sweet preloads. No differences in satiety were observed. To conclude, within one eating episode, within-meal protein content in these quantities seems not to have an effect on subsequent food choice. This appears to be mostly determined by taste, whereby savoury taste exerts the strongest modulating effect. The results of the LFPQ provided insight into underlying processes.
Power-Conferring Treaties: The Meaning of ‘Investment’ in the ICSID Convention
Authors: COLE TONY , VAKSHA ANUJ KUMAR 
Published: May 2011

AbstractIt is now standard in contemporary international law commentary to note that the latter part of the twentieth century has seen a move away from the traditional understanding of international law as fundamentally based on the consent of states. As just two examples, customary international law has in some contexts become more influential than treaties and human rights obligations are now recognized as often binding states even when they have signed no treaty acknowledging their existence. Treaty interpretation, by contrast, has remained focused upon the parties to a treaty, with even textualist approaches to treaty interpretation justified as the best means of ascertaining the intent of the contracting states. The purpose of the present article is to highlight the existence of a subset of treaties for which even a teleological approach to interpretation fails to capture the central importance for the treaty of entities other than the contracting states. These ‘power-conferring treaties’ do not merely entrust tribunals with the power to effectively fashion the means by which a treaty's goals should be achieved. To varying degrees, they grant control of the treaty itself, including, at times, both its enforcement and the very meaning of its terms, to entities other than the contracting states. As a result, the traditional emphasis in treaty interpretation on the ‘object and purpose’ of the treaty, and the precise language in which the treaty is written, will fail to generate an interpretation that faithfully captures the manner in which the treaty genuinely functions. The article then illustrates the potential impact of the power-conferring nature of a treaty through an analysis of the meaning of the term ‘investment’ in the International Convention for Settlement of Investment Disputes. This is one of the most controversial topics in contemporary international investment law, with an enormous impact upon the jurisdiction of ICSID arbitral tribunals. It is argued that recognizing the power-conferring nature of the ICSID Convention provides an enhanced understanding of the way in which this term should be interpreted.
Is the European Court of Human Rights Still a Principled Court of Human Rights After the Demopoulos Case?
Authors: LOUCAIDES LOUKIS G. 
Published: May 2011

AbstractOn 10 May 2001, the European Court of Human Rights delivered its judgment in the case of Cyprus v. Turkey pronouncing on the legal consequences of Turkey's invasion and occupation of the northern part of Cyprus since 1974. The Court found Turkey responsible for continuing violations of the right to the home and property of Greek-Cypriots. Invoking the Namibia principle, the Court found that remedies in the occupied part of Cyprus may be regarded as domestic remedies of Turkey and that the question of their effectiveness was to be considered in the specific circumstances in which it arises. On 1 March 2010, the Court decided that a Commission in the occupied area was a remedy that should be exhausted by the complainants for the above violations. Significant legal questions were determined relating to the effectiveness of this remedy with far-reaching consequences concerning the right to home and property as well as other aspects of human rights and international law.
Holding Counsel to Account in International Arbitration
Authors: McMULLAN SAM 
Published: May 2011

AbstractCounsel are regulated the world over in their dealings with a court of law through the enforcement of ethical duties that are owed by them. With the increased prevalence of arbitration in resolving disputes internationally, the question then arises: how are counsel kept in check when appearing before an arbitral tribunal? The issues involved are magnified when one considers the question in the context of international arbitral tribunals. This paper considers these issues by analysing them in three parts. First, is ethical regulation necessary in international arbitration? Second, does an arbitral tribunal have jurisdiction to consider and enforce ethical obligations owed to it by counsel? Third, what ethical obligations should be applied to counsel?
Determinants of anti-hepatitis A antibody seroprevalence in 2- to 19-year-olds in the USA using NHANES 2007–2008
Authors: VELASCO-MONDRAGON E. , LINDONG I. , KAMANGAR F. 
Published: May 2011

SUMMARYThe aim of the study was to describe the epidemiology and determinants of anti-hepatitis A seroprevalence in 2- to 19-year-olds in the USA for 2007–2008. This study was conducted in a sample of 2621 individuals aged 2–19 years in the USA using data from National Health and Nutrition Examination Survey (NHANES) 2007–2008. The overall seroprevalence of anti- hepatitis A virus (HAV) in this population was 39% (95% confidence interval 32·6–45·3). HAV seroprevalence was higher in Mexican Americans than other ethnic groups, in younger persons, and in those who reported previous vaccination compared to those who did not. We concluded that anti-hepatitis A seroprevalence rates are increasing in younger individuals in the USA, indicating a shift of seroprevalence over time due to vaccination status. Findings are consistent with a persistent influx of infection through international travel and migration and highlight the need to discern hepatitis A infection from vaccination status when assessing the effectiveness of vaccination using seroprevalence data.
Staining of Mitochondria with Cy5-Labeled Oligonucleotides for Long-Term Microscopy Studies
Authors: Lorenz Steffen , Tomcin Stephanie , Mailänder Volker 
Published: May 2011

AbstractLabeling of organelles for microscopy is achieved generally by specific dyes that either accumulate in a cellular compartment such as cyanine dyes in mitochondria or are only fluorescent under specific conditions such as the low pH in the lysosome. Here we demonstrate that Cy5—a fluorescent molecule that does not enter cells by itself—can be loaded into cells by attaching a short oligonucleotide. This very inexpensive labeling procedure can be done in the presence of serum. Therefore, very sensitive cell types should also be amenable to this procedure, and longer observations can be achieved compared to other commercially available dyes as the labeling reagent does not need to be washed out. This also points to the pitfall of using fluorescently labeled oligonucleotides for live cell imaging where the oligonucleotide is supposed to detect a specific target sequence in its subcellular distribution.
Extrasolar asteroid mining as forensic evidence for extraterrestrial intelligence
Authors: Forgan Duncan H. , Elvis Martin 
Published: May 2011

AbstractThe development of civilizations such as ours into spacefaring, multi-planet entities requires significant raw materials to construct vehicles and habitats. Interplanetary debris, including asteroids and comets, may provide such a source of raw materials. In this article, we present the hypothesis that extraterrestrial intelligences (ETIs) engaged in asteroid mining may be detectable from Earth. Considering the detected disc of debris around Vega as a template, we explore the observational signatures of targeted asteroid mining (TAM), such as unexplained deficits in chemical species, changes in the size distribution of debris and other thermal signatures that may be detectable in the spectral energy distribution (SED) of a debris disc. We find that individual observational signatures of asteroid mining can be explained by natural phenomena, and as such they cannot provide conclusive detections of ETIs. But, it may be the case that several signatures appearing in the same system will prove harder to model without extraterrestrial involvement. Therefore, signatures of TAM are not detections of ETI in their own right, but as part of ‘piggy-back’ studies carried out in tandem with conventional debris disc research, they could provide a means of identifying unusual candidate systems for further study using other search for extra terrestrial intelligence (SETI) techniques.
Informal payments for health care – the phenomenon and its context
Authors: Cohen Nissim 
Published: May 2011

AbstractThis paper reviews current research and literature on the issue of informal payments for health care and its context and suggests a new perspective for a better understanding of this phenomenon. This perspective, based on political culture and behavior and on wider social processes, is already used to explain various phenomena from different fields of public policy. The paper explains the impact of a specific type of political culture, called ‘alternative politics’ (AP) in the Israeli literature, on healthcare policy and institutional healthcare settings. AP is based on a ‘do-it-yourself’ approach adopted by citizens to address their dissatisfaction with governmental services. When such a mode of political culture is diffused to all sectors and levels of society, all players, including bureaucrats and politicians, are guided by short-term considerations and apply unilateral strategies that bypass formal rules either through illegal activity or by marginalizing formal rules. Explaining informal payments by analyzing social processes and political culture and behavior has some disadvantages, but it provides us with a better understanding of the phenomenon while covering most of its characteristics and configurations.
The Layha for the Mujahideen: an analysis of the code of conduct for the Taliban fighters under Islamic law
Authors: Munir Muhammad 
Published: May 2011

AbstractThe following article focuses on the Islamic Emirate of Afghanistan Rules for the Mujahideen** to determine their conformity with the Islamic jus in bello. This code of conduct, or Layha, for Taliban fighters highlights limiting suicide attacks, avoiding civilian casualties, and winning the battle for the hearts and minds of the local civilian population. However, it has altered rules or created new ones for punishing captives that have not previously been used in Islamic military and legal history. Other rules disregard the principle of distinction between combatants and civilians and even allow perfidy, which is strictly prohibited in both Islamic law and international humanitarian law. The author argues that many of the Taliban rules have only a limited basis in, or are wrongly attributed to, Islamic law.
The protective scope of Common Article 3: more than meets the eye
Authors: Pejic Jelena 
Published: May 2011

AbstractNon-international armed conflicts are not only prevalent today, but are also evolving in terms of the types that have been observed in practice. The article sets out a possible typology and argues that Common Article 3 to the Geneva Conventions may be given an expanded geographical reading as a matter of treaty law. It also suggests that there is a far wider range of rules – primarily of a binding nature, but also policy-based – that apply in Common Article 3 armed conflicts with regard to the treatment of persons in enemy hands and the conduct of hostilities.
Generating protein interaction maps from incomplete data:
application to fold assignment
Authors: Lappe Michael , Park Jong , Niggemann Oliver , Holm Liisa 
Published: May 2011

Abstract
Motivation: We present a framework to generate comprehensive overviews of protein-protein interactions. In the post-genomic view of cellular function, each biological entity is seen in the context of a complex network of interactions. Accordingly, we model functional space by representing protein-protein-interaction data as undirected graphs. We suggest a general approach to generate interaction maps of cellular networks in the presence of huge amounts of fragmented and incomplete data, and to derive representations of large networks which hide clutter while keeping the essential architecture of the interaction space. This is achieved by contracting the graphs according to domain-specific hierarchical classifications. The key concept here is the notion of induced interaction, which allows the integration, comparison and analysis of interaction data from different sources and different organisms at a given level of abstraction.
Results: We apply this approach to compute the overlap between the DIP compendium of interaction data and a dataset of yeast two-hybrid experiments. The architecture of this network is scale-free, as frequently seen in biological networks, and this property persists through many levels of abstraction. Connections in the network can be projected downwards from higher levels of abstraction down to the level of individual proteins. As an example, we describe an algorithm for fold assignment by network context. This method currently predicts protein folds at 30% accuracy without any requirement of detectable sequence similarity of the query protein to a protein of known structure. We used this algorithm to compile a list of structural assignments for previously unassigned genes from yeast. Finally we discuss ways forward to use interaction networks for the prediction of novel protein-protein interactions.
Availability: http://www.ebi.ac.uk/~lappe/FoldPred/
Contact: lappe@ebi.ac.uk
*To whom correspondence should be addressed.
Fragment assembly with double-barreled data
Authors: Pevzner Pavel A. , Tang Haixu 
Published: May 2011

Abstract
For the last twenty years fragment assembly was dominated by the “overlap - layout - consensus” algorithms that are used in all currently available assembly tools. However, the limits of these algorithms are being tested in the era of genomic sequencing and it is not clear whether they are the best choice for large-scale assemblies. Although the “overlap - layout - consensus” approach proved to be useful in assembling clones, it faces difficulties in genomic assemblies: the existing algorithms make assembly errors even in bacterial genomes. We abandoned the “overlap - layout - consensus” approach in favour of a new Eulerian Superpath approach that outperforms the existing algorithms for genomic fragment assembly (Pevzner et al. 2001 InProceedings of the Fifth Annual International Conference on Computational Molecular Biology (RECOMB-01), 256–26). In this paper we describe our new EULER-DB algorithm that, similarly to the Celera assembler takes advantage of clone-end sequencing by using the double-barreled data. However, in contrast to the Celera assembler, EULER-DB does not mask repeats but uses them instead as a powerful tool for contig ordering. We also describe a new approach for the Copy Number Problem: “How many times a given repeat is present in the genome?”. For long nearly-perfect repeats this question is notoriously difficult and some copies of such repeats may be “lost” in genomic assemblies. We describe our EULER-CN algorithm for the Copy Number Problem that proved to be successful in difficult sequencing projects.
Contact: ppevzner@ucsd.edu
Probabilistic approaches to the use of higher order clone

relationships in physical map assembly
Authors: States David J. , Nowotny Volker , Blackwell Thomas W. 
Published: May 2011

Abstract
Physical map assembly is the inference of genome structure from experimental data. Map assembly depends on the integration of diverse data including sequence tagged site (STS) marker content, clone sizing, and restriction digest fingerprints (RDF). As experimentally measured data, these are uncertain and error prone. Physical map assembly from error free data is straightforward and can be accomplished in linear time in the number of clones, but the assembly of an optimal map from error prone data is an NP-hard problem. We present an alternative approach to physical map assembly that is based on a probabilistic view of the data and seeks to identify those features of the map that can be reliably inferred from the available data. With this approach, we achieve a number of goals. These include the use of multiple data sources, appropriate representation of uncertainties in the underlying data, the use of clone length information in fingerprint map assembly, and the use of higher order information in map assembly. By higher order information, we mean relationships that are not expressible in terms of neighbouring clone relationships. These include triplet and multiple clone overlaps, the uniqueness of STS position, and fingerprint marker locations. In a probabilistic view of physical mapping, we assert that all of the many possible map assemblies are equally likely a priori. Given experimental data, we can only state which assemblies are more likely than others given the experimental observations. Parameters of interest are then derived as likelihood weighted averages over map assemblies. Ideally these averages should be sums or integrals over all possible map assemblies, but computationally this is not feasible for real-world map assembly problems. Instead, sampling is used to asymptotically approach the desired parameters. Software implementing our probabilistic approach to mapping has been written. Assembly of mixed RDF and STS maps containing up to 60 clones can be accomplished on a desktop PC with run times under an hour.
Availability: http://stl.wustl.edu/software/gibbsmap/
Contact: states@ccb.wustl.edu
Computational expansion of genetic networks
Authors: Tanay Amos , Shamir Ron 
Published: May 2011

Abstract
We present a new methodology for computational analysis of gene and protein networks. The aim is to generate new educated hypotheses on gene functions and on the logic of the biological network circuitry, based on gene expression profiles. The framework supports the incorporation of biologically motivated network constraints and rules to improve specificity. Since current data is insufficient for de-novo reconstruction, the method receives as input a known pathway core and suggests likely expansions to it. Network modeling is combinatorial, yet data can be probabilistic. At the heart of the approach are a fitness function which estimates the quality of suggested network expansions given the core and the data, and a specificity measure of the expansions. The approach has been implemented in an interactive software tool called GENESYS. We report encouraging results in preliminary analysis of yeast ergosterol pathway based on transcription profiles. In particular, the analysis suggests a novel ergosterol transcription factor.
Contact: rshamir@tau.ac.il
Centralization: a new method for the normalization of gene

expression data
Authors: Zien Alexander , Aigner Thomas , Zimmer Ralf , Lengauer Thomas 
Published: May 2011

Abstract
Microarrays measure values that are approximately proportional to the numbers of copies of different mRNA molecules in samples. Due to technical difficulties, the constant of proportionality between the measured intensities and the numbers of mRNA copies per cell is unknown and may vary for different arrays. Usually, the data are normalized (i.e., array-wise multiplied by appropriate factors) in order to compensate for this effect and to enable informative comparisons between different experiments. Centralization is a new two-step method for the computation of such normalization factors that is both biologically better motivated and more robust than standard approaches. First, for each pair of arrays the quotient of the constants of proportionality is estimated. Second, from the resulting matrix of pairwise quotients an optimally consistent scaling of the samples is computed.
Contact: Alexander.Zien@gmd.de
Gene recognition based on DAG shortest paths
Authors: Chuang John S. , Roth Dan 
Published: May 2011

Abstract
We describe Dagger, an ab initio gene recognition program which combines the output of high dimensional signal sensors in an intuitive gene model based on directed acyclic graphs. In the first stage, candidate start, donor, acceptor, and stop sites are scored using the SNoW learning architecture. These sites are then used to generate a directed acyclic graph in which each source-sink path represents a possible gene structure. Training sequences are used to optimize an edge weighting function so that the shortest source-sink path maximizes exon-level prediction accuracy. Experimental evaluation of prediction accuracy on two benchmark data sets demonstrates that Daggeris competitive with ab initio gene finding programs based on Hidden Markov Models.
Contact: jsc@ocf.berkeley.edu, danr@cs.uiuc.edu