bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, Structure, and Photophysical Properties of Some Gadolinium(III) Porphyrinate Complexes
Authors: Zhu Xun‐Jin , Zhang Tao , Zhao Shunsheng , Wong Wai‐Kwok , Wong Wai‐Yeung 
Published: June 2011

AbstractA series of gadolinium(III) porphyrinate complexes was synthesized in moderate yield from the interaction of meso‐substituted porphyrin free bases with Ln[N(SiMe3)2]3·x[LiCl(THF)3], followed by the addition of a tripodal anion LOMe– – an effective encapsulating agent for lanthanide ions. These new complexes were fully characterized by X‐ray crystallography, elemental analysis, mass spectrometry, and infrared spectroscopy. The electronic spectra show a near‐infrared phosphorescence from the triplet state of the porphyrin rings and exhibit a very characteristic vibronic‐structured emission.
Aminotroponiminate and Aminotroponate Complexes of Group 15 (P, As) Elements: Synthesis, X‐ray Diffraction Analysis and Reactivity
Authors: Pop Lucian‐Cristian , Castel Annie , Silaghi‐Dumitrescu Luminita , Saffon Nathalie 
Published: June 2011

AbstractNew phosphenium and arsenium cations stabilized by bidentate monoanionic N‐isopropyl‐2‐(isopropylamino)troponiminate or 2‐(isopropylamino)troponate units have been synthesized. These complexes were characterized by 31P, 1H and 13C NMR spectroscopy and the molecular structures were determined by X‐ray crystallography. These data indicate the formation of N,N′‐ and N,O‐chelate derivatives with three‐coordinate Group 15 atoms included in planar heterobicycles. The reactivities of these cationic species were investigated. The phosphenium cations were found to be more reactive than their arsenium analogues, especially towards an o‐quinone, with the formation of a phosphate ester derivative. Complexation reactions with [(THF)W(CO)5] afforded the first aminotroponiminato hydroxyphosphenium cation stabilized by coordination to a transition metal.
Ultrasound‐Induced Rapid Intercalation of Biselenite in Layered Double Hydroxides
Authors: Lee Jong Hyeon , Lee Yeon Soo , Kim Hana , Jung Duk‐Young 
Published: June 2011

AbstractThe deintercalation of carbonate (CO32–) ions from MgAl‐layered double hydroxides (LDHs) (Mg/Al = 2) both in monolayer films and powdered samples under atmospheric conditions in ethanol was investigated. A selenous acid precursor was incorporated into the interlayer gallery. Treatment with 0.5 M selenous acid (H2SeO3) for 30 min with powdered LDHs or with 0.1 M H2SeO3 for 5 min with the thin film LDHs resulted in carbonate ions being exchanged with biselenite (HSeO3–) ions. Electron microscopy showed that the morphologies of the original LDH particles remained after the reaction, despite the ultrasound being continuously applied for up to 2 h. XRD, FTIR and Raman spectroscopic scattering results strongly suggested that cyclic dimers of biselenite ions were incorporated into the gallery spaces of the LDHs, vertically arranged to the horizontal axes of the MgAl‐LDH layers.
Symmetrical Bis(acetylido)ruthenium(II) Complexes
Authors: Field Leslie D. , Magill Alison M. , Shearer Timothy K. , Dalgarno Scott J. , Bhadbhade Mohan M. 
Published: June 2011

AbstractSymmetrical, mononuclear bis(acetylido)ruthenium(II) complexes were prepared by the reaction of [trans‐RuMe2(dmpe)2] [dmpe = 1,2‐bis(dimethylphosphanyl)ethane] with terminal alkynes. The complexes were characterised by multinuclear NMR spectroscopy and X‐ray crystallography. In some cases, the complexes catalyse the head‐to‐head dimerisation of terminal alkynes to yield organic butenynes. The regiochemistry of this dimerisation depends on the solvent used; methanol results in the isolation of (Z)‐butenynes, whereas toluene gives predominantly (E) isomers.
Stepwise Synthesis of Siloxane‐Substituted Oligophosphanes Pn[O(iPr2Si)2]2 (n = 2, 4)
Authors: Kracke Andreas , von Hänisch Carsten 
Published: June 2011

AbstractThe synthesis of siloxane‐bridged P2 and P4 compounds can be achieved through metalation of primary or cyclic diphosphanylsiloxane compounds and subsequent oxidative coupling using C2H4Br2 as reagent. Starting from the cyclic diphosphanylsiloxane [O(iPr2Si)2PH]2, the reaction with the silazanides of the earth alkaline metals leads to the metalated compounds [M(DME)2{O(iPr2Si)2P}2] (1: M = Ca, 2: M = Sr, 3: M = Ba). Subsequent oxidation yields the bicyclic species P2[O(iPr2Si)2]2 (4). In an analogous reaction sequence with the primary diphosphanylsiloxane O(iPr2Si)2PH2 the cyclic diphosphane O(iPr2SiPH)2 (5) could be obtained and was successfully used for the same reaction pathway, leading to the corresponding metalated compound 6. Further oxidative coupling resulted in an intermolecular P–P bond formation, yielding the cage compound P4[O(iPr2Si)2]2 (7).
Cyanide‐Bridged Molecular Squares – The Building Units of Prussian Blue (Eur. J. Inorg. Chem. 20/2011)
Authors: Newton Graham N. , Nihei Masayuki , Oshio Hiroki 
Published: June 2011

AbstractThe cover picture shows two examples of the diverse physical properties observed in cyanide‐bridged molecular square complexes: multistep spin crossover and electron transfer coupled spin transition. Cyanide‐bridged squares can be considered to be the building blocks of Prussian Blue, which forms the backdrop of the image, and their discrete nature can allow easy access to multistable functionalities. The Microreview by H. Oshio et al. on p. 3031 ff. discusses the syntheses and physical properties of cyanide‐bridged molecular squares since the discovery of the first high‐spin example in 1999.
Composition and antioxidant and antimicrobial activities of white apricot almond (Amygdalus communis L.) oil
Authors: Tian Honglei , Zhang Hao , Zhan Ping , Tian Fengwei 
Published: June 2011

AbstractIn order to improve the level of comprehensive utilization and to promote the development of functional products, the chemical composition of white apricot almond oil was analyzed by capillary GC‐MS and interpreted based on the standard mass spectral data, and biological activities were evaluated. Seven components of white apricot almond oil were identified. The scavenging capacity of white apricot almond oil in the superoxide anion radical system and hydroxyl radical system had a good performance. The IC50 of white apricot almond oil to superoxide anion radical system and hydroxyl radical were 5.8 µg/mL and 0.17 mg/mL, respectively, and were stronger than that of ascorbic acid. In DPPH system, the IC50 value of white apricot almond oil was 0.2 mg/mL and the IC50 value of ascorbic acid was 0.07 mg/mL, but within the selected dosage, the highest scavenging capacity of white apricot almond oil was higher than that of ascorbic acid. White apricot almond oil was found to be a more effective antimicrobial agent than grape seed oil, fuji apple seed oil and mulberry seed oil. The minimum inhibitory concentration (MIC) of white apricot almond oil ranged from 0.2 to 0.4 mg/mL. The observed biological activities showed that the oil has a good potential for use in the food industry and pharmacy.
Delivery of radioiodinated antisense oligonucleotides in long circulating liposomes in vivo
Authors: Ma Chao , Lin Jizheng , Xie Jiawei , Wang Guoming , Shuyao Zuo 
Published: June 2011

AbstractThe anionic long circulating liposomes (ALCLs) prepared in previous studies enabled high loading efficiency, small particle size, and good stability. In addition, the uptake by tumor cells and delivery of radioiodinated antisense oligonucleotides (ASON) to MCF‐7 breast cancer cell line was improved. The liposomes also displayed valuable pharmacologic properties characterized by a long half‐life, slow clearance, and a significant area under the concentration–time curve (AUC) in vivo. This study emphasizes the contribution of ALCLs to the anti‐tumor effect of ASON and radiation therapy. Our results show that ALCLs improve biodistribution and delivery of radioiodinated ASON in tumor bearing rats, which is characterized by the suppression of tumor growth, decreased bcl‐2 expression, and increased tumor cell necrosis in the mammary tumor.
Stereoselective Synthesis and Biological Evaluation of Ferrocene‐Containing 5‐Hydroxyeicosatetraenoic Acid Analogues
Authors: Kausch‐Busies Nina , Neudörfl Jörg Martin , Wefelmeier Pascal , Prokop Aram , Kühn Hartmut , Schmalz Hans‐Günther 
Published: June 2011

AbstractThe stereoselective synthesis of a set of four stable 5‐hydroxyeicosatetraenoic acid (HETE) analogues with a ferrocene backbone is described. The common substructure of all HETEs, the (2E,4Z)‐1‐hydroxyhexadiene moiety, was formally replaced by a ferrocenylmethanol fragment. Whereas the hydrophilic side chain remained the same as that of 5‐HETE (butyrate), the lipophilic side chain was simplified by replacing the “natural” (Z,Z)‐1,4‐decadiene side chain with (Z)‐1‐heptene, 1‐heptyne, 1‐octyne, or phenylacetylene. As a key building block, Kagan's chiral acetal (derived from ferrocenecarbaldehyde) was used for the stereoselective generation of the planar‐chiral substructure through diastereoselective ortho‐lithiation and subsequent formylation, methoxycarbonylation or iodination, respectively. The lipophilic side chain was installed either by a “salt‐free” Wittig reaction or (better) by Pd‐catalyzed Sonogashira coupling. The (Z)‐selective semi‐reduction of a (hindered) triple bond was achieved with NaBH4, PdI2 and PEG200. The introduction of the hydrophilic side chain was found to proceed with complete diastereoselectivity through addition of a titanium–zinc organyl [prepared from ethyl 4‐iodobutyrate, activated Zn powder and Ti(OiPr)3Cl] as a butyrate D4 synthon to an aldehyde function using 2‐methyltetrahydrofuran (2‐Me‐THF) as a solvent. The expected (Rp,5S) configuration of the products was confirmed by X‐ray crystallography of an intermediate and by chemical correlation and NMR spectroscopy of a Mosher‐type derivative. Preliminary biological experiments revealed that compound 4 [with a (Z)‐heptenyl side chain] displayed significant apoptosis induction, whereas analogues with an alkynyl side chain were inactive. None of the HETE analogues prepared showed significant inhibition of lipoxygenase (15‐LOX) or cyclooxygenase (COX‐2).
Design and Synthesis of Fluorescent Sensors for Zinc Ion Derived from 2‐Aminobenzamide
Authors: Jia Jia , Gu Zhen‐yuan , Li Ri‐chen , Huang Ming‐hao , Xu Cai‐shuang , Wang Yi‐fei , Xing Guo‐wen , Huang Yun‐sheng 
Published: June 2011

AbstractFour novel Zn2+ fluorescent sensors have been designed with N,N‐bis(2‐pyridylmethyl)ethylenediamine as chelator and 2‐aminobenzamide as fluorophore. These sensors were prepared in two or three steps from readily available starting materials. Of the four designed sensors, ZnABA was found to be the most efficient Zn2+‐specific fluorescent probe and has good solubility in biological buffer, a large Stokes shift (186 nm), a high off–on fluorescence response (16‐fold enhancement), and distinct selectivity towards Zn2+ over other metal ions. Our results have demonstrated an excellent linear relationship between the fluorescence intensity of ZnABA and the Zn2+ concentration from 0 to 10 μM, which indicates that ZnABA has the potential to be used for the quantitative determination of Zn2+ in an aqueous environment.
A New Solvent‐Free Reaction for the Preparation of Alkoxysilane from Cyclic Ethers, Alcohols, or Carbonyl Compounds
Authors: Pehlivan Leyla , Métay Estelle , Boyron Olivier , Demonchaux Patrice , Mignani Gérard , Lemaire Marc 
Published: June 2011

AbstractThe 1,1,3,3‐tetramethyldisiloxane/Pd/C system is reported here as a new method to accomplish the ring‐opening of ethers and epoxides to give protected alcohols. The approach can also be used for the protection of primary or secondary alcohols and for the reduction of aldehydes and ketones to obtain alkoxysilanes.
Synthesis of DNA with Green Perylene Bisimides as DNA Base Substitutions
Authors: Menacher Florian , Wagenknecht Hans‐Achim 
Published: June 2011

AbstractPerylene‐3,4:9,10‐tetracarboxylic acid bisimide represents a particularly attractive building block for DNA‐based multichromophores and nanoassemblies due to its unique combination of optical and electronic properties. Despite the broad applicability of the perylene bisimide dye for DNA‐based assemblies, significant fluorescence quenching by photoinduced charge‐transfer processes to guanines in DNA represents a major disadvantage. In order to develop a redox actively and optically tuned perylene bisimide derivative with fluorescence that does not photooxidize guanines in DNA, we chose to attach two N‐pyrrolidinyl substituents as strongly electron‐donating substituents at the 1‐ and 7‐positions of the bay area (“APBI”). The corresponding phosphoramidite 1 was synthesized and incorporated synthetically into oligonucleotides by using the automated DNA building block chemistry. The 2′‐deoxyribofuranoside of natural nucleosides was replaced by (S)‐1‐aminopropane‐2,3‐diol as an acyclic linker between the phosphodiester bridges that is tethered to one of the imide nitrogen atoms of the APBI dye. Electrochemical and optical characterization of the isolated APBI dye shows that photoinduced charge transfer with guanines is indeed very unlikely. Single APBI DNA base substitutions show an exciplex‐type emission with pH sensitivity. The interstrand APBI dimer in DNA could be regarded as a hydrophobically interacting base pair that stabilizes the thermal stability of the double strand. The APBI dimer behaves like an H aggregate, and the fluorescence is quenched quantitatively.
Transition‐Metal‐Catalyzed Cyclopropanation of Nonactivated Alkenes in Dibromomethane with Triisobutylaluminum
Authors: Brunner Gerhard , Elmer Susanne , Schröder Fridtjof 
Published: June 2011

AbstractThe cyclopropanation of nonactivated alkenes with inexpensive triisobutylaluminum (TIBA), in dibromomethane as solvent and reagent, is efficiently catalyzed by FeCl3 at ambient temperature. Catalytic amounts of CuI salts, CpTiCl3, and [CpFe(CO)2]2 are similarly effective. 2‐Methylpropane, generated after quench of excess TIBA can be trapped, and excess dibromomethane can be recycled, which makes the method industrially applicable. Solvent‐free DIBAH or TIBA reduction of unsaturated carbonyl compounds, followed by in situ TIBA cyclopropanation of the unsaturated aluminum alcoholates in dibromomethane give cyclopropyl alkanols. Dienols such as geraniol, linalool or nor‐radjanol are selectively cyclopropanated in their distal position, which allows the synthesis of flavor and fragrance compounds such as Δ‐citral, cis‐javanol, and 7‐methyl‐georgywood. Uncontrollable exothermic events are avoided due to relatively low reaction temperatures made possible by the catalysts and by the addition mode of the reagents.1
Can't get over me: Ego depletion attenuates prosocial effects of perspective taking
Authors: Fennis Bob M. 
Published: June 2011

AbstractMany studies attest to the beneficial and prosocial effects of perspective taking. The present research tests the notion that such perspective taking is a process involving active self‐regulation and, hence, that effects of perspective taking on prosocial behaviour are more pronounced when self‐control resources are high, rather than low. Results confirmed this hypothesis. Across two experiments using acts of compliance as a specific form of prosocial behaviour, perspective‐taking participants were more willing to comply with a request for help by the experimenter (experiment 1) and donated more time to a charitable cause (experiment 2) than participants who did not engage in perspective taking, but only when self‐regulatory resources were in sufficient supply. Under conditions of ego depletion, the impact of perspective taking on compliance was attenuated. Copyright © 2011 John Wiley & Sons, Ltd.
A Fast and Direct Amperometric Determination of Hg2+ by a Bienzyme Electrode Based on the Competitive Activities of Glucose Oxidase and Laccase
Authors: Cosnier Serge , Mousty Christine , Guelorget Amandine , Lopez Marta Sanchez‐Paniagua , Shan. Dan 
Published: June 2011

AbstractA new concept of enzyme inhibition‐based biosensor involving the appearance of an amperometric signal for an inhibition by mercury was developed. The bienzyme sensor was composed of two layers of clay materials. The inner layer was constituted of layered double hydroxides entrapping laccase wired by ABTS. The outer laponite layer contained glucose oxidase (GOD). GOD catalyzed the glucose oxidation with the reduction of O2 into H2O2. This induced a drastic decrease of the biosensor response to O2 by the electrically wired laccase. HgCl2 inhibited the O2 consumption by GOD leading to a signal increase of the electroenzymatic reduction of O2.
Capillary electrophoresis method for plasmatic determination of imatinib mesylate in chronic myeloid leukemia patients
Authors: Ajimura Tatiana O. , Borges Keyller B. , Ferreira Aline F. , de Castro Fabíola A. , de Gaitani Cristiane M. 
Published: June 2011

AbstractImatinib (IMAT) is a tyrosine kinase inhibitor that has been used for the treatment of chronic myeloid leukemia (CML). Despite the efficacy of IMAT therapy, some cases of treatment resistance have been described in CML. Developing a plasma method is important since there are several studies that provided a higher correlation between IMAT plasma concentration and response to treatment. Therefore, in this investigation we validated a method by CE as an alternative, new, simple and fast electrophoretic method for IMAT determination in human plasma. The analysis was performed using a fused silica capillary (50 μm id×46.5 cm total length, 38.0 cm effective length); 50 mmol/L sodium phosphate buffer, pH 2.5, as BGE; hydrodynamic injection time of 20 s (50 mbar); voltage of 30 kV; capillary temperature of 35°C and detection at 200 nm. Plasma samples pre‐treatment involved liquid–liquid extraction with methyl‐tert‐butyl ether as the extracting solvent. The method was linear from 0.125 to 5.00 μg/mL. The LOQ was 0.125 μg/mL. Mean absolute recovery of IMAT was 67%. The method showed to be precise and accurate with RSD and relative error values lower than 15%. Furthermore, the application of the method was performed in the analysis of plasma samples from CML patients undergoing treatment with IMAT.
Electrokinetic particle translocation through a nanopore containing a floating electrode
Authors: Zhang Mingkan , Ai Ye , Sharma Ashutosh , Joo Sang W. , Kim Dong‐Soo , Qian Shizhi 
Published: June 2011

AbstractElectrokinetic particle translocation through a nanopore containing a floating electrode is investigated by solving a continuum model, composed of the coupled Poisson–Nernst–Planck (PNP) equations for the ionic mass transport and the modified Stokes equations for the flow field. Two effects due to the presence of the floating electrode, the induced‐charge electroosmosis (ICEO) and the particle‐floating electrode electrostatic interaction, could significantly affect the electrokinetic mobility of DNA nanoparticles. When the electrical double layers (EDLs) of the DNA nanoparticle and the floating electrode are not overlapped, the particle‐floating electrode electrostatic interaction becomes negligible. As a result, the DNA nanoparticle could be trapped near the floating electrode arising from the induced‐charge electroosmosis when the applied electric field is relatively high. The presence of the floating electrode attracts more ions inside the nanopore resulting in an increase in the ionic current flowing through the nanopore; however, it has a limited effect on the deviation of the current from its base current when the particle is far from the pore.
Equipment design and facility layout for flexible biomanufacturing processes
Authors: Peuker Thorsten , Bogner Alexandra 
Published: June 2011

AbstractIn process development and manufacturing, the biopharmaceutical industry requires high flexibility in its production facilities. These suites must be capable of producing clinical material or even drug substances for the market. Several products are manufactured in parallel or shortly after one another, which is challenging especially for the equipment. Product titers are increasing due to improved cell line performances, and personalized medicine will lead to tailor‐made drugs for a smaller group of patients. The resulting reduced upstream volumes enhance the opportunities for complete single‐use manufacturing trains. These requirements must be considered already during the design phase of the manufacturing facility. Engineering efforts have to be reduced as much as possible in order to reduce cost and timelines. Generic platform concepts for the overall process enable a shorter execution time as well as more efficient qualification procedures. In this contribution, the focus is on production processes for monoclonal antibodies (mAb) as a major product class of the biopharmaceutical industry. Two case studies introduce process platform concepts integrating single‐use equipment for an existing building and for a greenfield facility.
Examining the Match between Assessed Eating Disorder Recovery and Subjective Sense of Recovery: Preliminary Findings
Authors: Bardone‐Cone Anna M. 
Published: June 2011

AbstractThis study examined how individuals, clinically assessed as fully or partially recovered from an eating disorder (ED), subjectively perceived themselves in terms of stage of change in the recovery process. Individuals formerly seen for an ED at a Midwestern clinic were recruited. Using validated definitions of recovery, 18 were fully recovered (physical, behavioural and psychological recovery), and 15 were partially recovered (only physical and behavioural recovery); these groups were compared on overall stage of change and confidence related to this stage, dieting stage of change and internality of motivation. The fully and partially recovered groups endorsed being fully recovered (overall and for dieting) at similar rates. There were trends for the fully recovered group seeking change primarily for themselves and being more confident in their stage of change choice. Results have implications for approaches when a client's assessed recovery stage does not match her subjective sense of recovery and for better understanding recovery from an ED. Copyright © 2011 John Wiley & Sons, Ltd and Eating Disorders Association.
A Grounded Theory Exploration of the Onset of Anorexia in Adolescence
Authors: Koruth Nina , Nevison Charlotte , Schwannauer Matthias 
Published: June 2011

AbstractObjectivesRelatively little research has been conducted investigating the individual's point of view of anorexia. This research explored young people's experiences of the onset of anorexia. It was anticipated that this would improve clinicians' knowledge in this area, which could then inform establishing alliance and progress through interventions.MethodA qualitative grounded theory design was employed. Eight participants aged between 13 and 17 years took part in an interview. The procedure of analysis involved moving between the interviews and generating codes.ResultsSuperordinate themes emerged and the three main findings are presented. Firstly, it was found that emotions were experienced as overwhelming. Secondly, that the level of awareness of anorexia develops. Finally, that emotional responses and the level of awareness of anorexia impact on the ability to utilise interpersonal interactions. The findings shed light on the personal experiences of this time and help to highlight areas for clinicians to address. Copyright © 2011 John Wiley & Sons, Ltd and Eating Disorders Association.