bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unraveling the core symptoms of mental health in senior grade three students- a network analysis
Authors: Fang Guoxiang , Wang Ying , Yuan Huiling , Yan Ne , Zhi Shaomin 
Published: April 2024

BackgroundAdolescence is not only an important transitional period of many developmental challenges, but also a high risk period for mental health problems. Psychotherapy is recommended for mental health problems in adolescents, but its effectiveness is not always satisfactory. One possible contributing factor may be the lack of clarity surrounding core symptoms.MethodsIn this study, we investigated the mental health status of senior grade three students, a group of adolescents facing college entrance exams, by the Middle School Student Mental Health Test (MHT) and analyzed the core symptoms by network analysis. This study was conducted through an online survey platform (www.xiaodongai.com) from 15 February 2023 to 28 March 2024. The subjects scanned a QR code with their mobile phone to receive the questionnaire.ResultsThe mean age of these 625 students were 18.11 ± 2.90 years. There are 238 male participants and 387 female participants. 107 individuals scored above 56 (107/461, 23.2%), with individual scale scores over 8 up to over 60% of participating students. Notably, the top three prominent symptoms were “academic anxiety”, “allergic tendency” and “somatic symptoms”. However, upon conducting network analysis, it became evident that three strongest edges in this network were “somatic symptoms” and “impulsive tendency”, “academic anxiety” and “social anxiety” as well as “social anxiety” and “Loneliness tendency”. “somatic symptoms”, “social anxiety” and “self-blame tendency” exerted the highest expected influence. This suggests that, statistically speaking, these three symptoms exhibited the strongest interconnections within the network.LimitationCross-sectional analysis; Bias in self-reported variables.ConclusionThese findings can deepen the knowledge of mental health among senior grade three students and provide some implications (i.e., targeting symptoms having highest expected influence) for clinical prevention and intervention to address the mental health needs of this particular group.
Electroacupuncture stimulation modulates functional brain connectivity in the treatment of pediatric cerebral palsy: a case report
Authors: Sun Zongbo , Li Chenglin , Sun Laixin , Yang Wenwen , Qu Xueli , Li Yuanyuan , Duan Xiao , Guo Fengyu , Sun Xuejing , Yang Mingzhu , Qi Tong , Zhu Longyun , Wang Shuai , Xia Yu , Du Yanan , Luo Shuhui , Li Lingling , Gu Yu , Wang Yaya , Yang Li 
Published: April 2024

BackgroundPediatric cerebral palsy (CP) is a non-progressive brain injury syndrome characterized by central motor dysfunction and insufficient brain coordination ability. The etiology of CP is complex and often accompanied by diverse complications such as intellectual disability and language disorders, making clinical treatment difficult. Despite the availability of pharmacological interventions, rehabilitation programs, and spasticity relief surgery as treatment options for CP, their effectiveness is still constrained. Electroacupuncture (EA) stimulation has demonstrated great improvements in motor function, but its comprehensive, objective therapeutic effects on pediatric CP remain to be clarified.MethodsWe present a case of a 5-year-old Chinese female child who was diagnosed with CP at the age of 4. The patient exhibited severe impairments in motor, language, social, and cognitive functions. We performed a 3-month period of EA rehabilitation, obtaining resting state functional magnetic resonance imaging (rs-fMRI) of the patient at 0 month, 3 months and 5 months since treatment started, then characterized brain functional connectivity patterns in each phase for comparison.ResultsAfter a 12-month follow-up, notable advancements were observed in the patient’s language and social symptoms. Changes of functional connectivity patterns confirmed this therapeutic effect and showed specific benefits for different recovery phase: starting from language functions then modulating social participation and other developmental behaviors.ConclusionThis is a pioneering report demonstrating the longitudinal effect of EA stimulation on functional brain connectivity in CP patients, suggesting EA an effective intervention for developmental disabilities (especially language and social dysfunctions) associated with pediatric CP.
How internet healthcare information overflow affects farmers’ healthcare consumption: insights from China
Authors: Ming Yu , Xia Chen 
Published: April 2024

IntroductionIn the context of the deep coupling and synergistic development of digital villages and healthy villages, the development of China’s rural society harbors a huge potential for medical and healthcare consumption.MethodsOn the basis of theoretical research, a framework was constructed to analyze the influence mechanism of farmers’ medical and healthcare consumption in the context of Internet medical information overflow, and empirically examines the research and analysis framework by using the 2020 China Household Tracking Survey data with the OLS model, mediation effect model, and instrumental variable method.ResultsIt is found that Internet medical information spillover has a “crowding-in effect” on farmers’ healthcare consumption; Medical attendance behavior, economic capital utilize the intermediary effect between Internet medical information spillover and farmers’ healthcare consumption. And there is age group heterogeneity in the effect of Internet medical information spillover on farmers’ healthcare consumption, The ability of rural middle-aged and old-aged groups to recognize new things such as Internet medical information needs to be improved, so the overflow of Internet medical information will induce rural middle-aged and old-aged groups to generate a certain amount of medical and health care consumption. However, the impact on healthcare consumption is not sensitive to the youth cohort group.DiscussionThe sinking of Internet medical resources should be accelerated in the future to promote the high-quality development of rural medical and health services, at the same time the “Internet + healthcare services” should be optimized to promote scientific and rational stratification of farmers’ access to healthcare, and economic capital for farmers’ access to health care should be improved in order to alleviate the burden of health care, etc.
Value contribution of blood-based neurofilament light chain as a biomarker in multiple sclerosis using multi-criteria decision analysis
Authors: Monreal Enric , Ruiz Pilar Díaz , San Román Isabel López , Rodríguez-Antigüedad Alfredo , Moya-Molina Miguel Ángel , Álvarez Ana , García-Arcelay Elena , Maurino Jorge , Shepherd John , Cabrera Álvaro Pérez , Villar Luisa María 
Published: April 2024

IntroductionMultiple sclerosis (MS) is a chronic autoimmune demyelinating disease that represents a leading cause of non-traumatic disability among young and middle-aged adults. MS is characterized by neurodegeneration caused by axonal injury. Current clinical and radiological markers often lack the sensitivity and specificity required to detect inflammatory activity and neurodegeneration, highlighting the need for better approaches. After neuronal injury, neurofilament light chains (NfL) are released into the cerebrospinal fluid, and eventually into blood. Thus, blood-based NfL could be used as a potential biomarker for inflammatory activity, neurodegeneration, and treatment response in MS. The objective of this study was to determine the value contribution of blood-based NfL as a biomarker in MS in Spain using the Multi-Criteria Decision Analysis (MCDA) methodology.Materials and methodsA literature review was performed, and the results were synthesized in the evidence matrix following the criteria included in the MCDA framework. The study was conducted by a multidisciplinary group of six experts. Participants were trained in MCDA and scored the evidence matrix. Results were analyzed and discussed in a group meeting through reflective MCDA discussion methodology.ResultsMS was considered a severe condition as it is associated with significant disability. There are unmet needs in MS as a disease, but also in terms of biomarkers since no blood biomarker is available in clinical practice to determine disease activity, prognostic assessment, and response to treatment. The results of the present study suggest that quantification of blood-based NfL may represent a safe option to determine inflammation, neurodegeneration, and response to treatments in clinical practice, as well as to complement data to improve the sensitivity of the diagnosis. Participants considered that blood-based NfL could result in a lower use of expensive tests such as magnetic resonance imaging scans and could provide cost-savings by avoiding ineffective treatments. Lower indirect costs could also be expected due to a lower impact of disability consequences. Overall, blood-based NfL measurement is supported by high-quality evidence.ConclusionBased on MCDA methodology and the experience of a multidisciplinary group of six stakeholders, blood-based NfL measurement might represent a high-value-option for the management of MS in Spain.
Suggesting global insights to local challenges: expanding financing of rehabilitation services in low and middle-income countries
Authors: Bachani Abdulgafoor M. , Bentley Jacob A. , Kautsar Hunied , Neill Rachel , Trujillo Antonio J. 
Published: April 2024

PurposeFollowing the rapid transition to non-communicable diseases, increases in injury, and subsequent disability, the world—especially low and middle-income countries (LMICs)—remains ill-equipped for increased demand for rehabilitative services and assistive technology. This scoping review explores rehabilitation financing models used throughout the world and identifies “state of the art” rehabilitation financing strategies to identify opportunities and challenges to expand financing of rehabilitation.Material and methodsWe searched peer-reviewed and grey literature for articles containing information on rehabilitation financing in both LMICs and high-income countries.ResultsForty-two articles were included, highlighting various rehabilitation financing mechanism which involves user fees and other innovative payment as bundled or pooled schemes. Few studies explore policy options to increase investment in the supply of services.Conclusionthis paper highlights opportunities to expand rehabilitation services, namely through promotion of private investment, improvement in provider reimbursement mechanism as well as expanding educational grants to bolster labor supply incentive, and the investment in public and private insurance schemes. Mechanisms of reimbursement are frequently based on global budget and salary which are helpful to control cost escalation but represent important barriers to expand supply and quality of services.
Utilization of the Integrated Management of Newborn and Childhood Illness (IMNCI) protocol and associated factors among health care workers in health centers of South Gondar Zone, Northwest Ethiopia: an institution-based mixed study
Authors: Belete Abraham Addis , Agumas Yeshambel , Tsehay Asmamaw Ketemaw , Ayele Habtamu Molla 
Published: April 2024

IntroductionGlobally, 11 million children have died before reaching their fifth birthday. The introduction of the Integrated Management of Newborn and Childhood Illness (IMNCI) protocol reduces the morbidity and mortality rates among children under the age of 5. However, the share of neonatal mortality is increasing. As a result, the United Nations has established sustainable development goals to reduce national neonatal death rates through the utilization of the Integrated Management of Newborn and Childhood Illness protocol as the main tool for 12 per 1,000 live births by 2030. However, the death rate from preventable causes has increased owing to the low utilization of the protocol.ObjectiveThe objective of this research is to assess the utilization of the IMNCI protocol and associated factors among healthcare workers (HCW) in health centers at the South Gondar Zone, Northwest Ethiopia, in 2022.MethodsThe institution-based mixed study design was conducted from November to December 2022 at the South Gondar Zone, Amhara. A total of 422 HCW were selected using a computer-generated random-number generator. Data were cleaned and entered into EpiData 3.1 software and analyzed using SPSS version 25.0. Binary logistic regression was used to identify candidates for multivariable logistic analysis with p-value &lt; 0.2, and for multivariable analysis, p-value &lt; 0.05, with a 95% confidence interval, was considered significant. Thematic analysis was used for the qualitative data.ResultsIn total, 417 respondents were included in the final analysis. The overall response rate was 98.8%, and the mean age was 30.01 years. The results showed that the proportion of IMNCI utilization was 63.1%. The odds of the utilization of IMNCI protocol among HCW who took training were 3.13 times higher than those among HCW who did not take training [adjusted odds ratio (AOR) = 3.13, 95% CI: 1.594, 6.147]. The lack of drugs reduces the utilization of the IMNCI protocol by 75.7% compared with the use of drugs (AOR = 0.243, CI: 95%:0.128, 0.464). HCW who always referred to the chart booklet during case management were 3.34 times more likely to utilize the IMNCI protocol (AOR = 3.34, 95% CI: 1.99, 5.60) compared with those who did not refer to the chart booklet.Conclusions and recommendationsThe utilization of the IMNCI protocol was low. A shortage of medical consumables and equipment attitude and training were identified as factors that affected the utilization of the protocol. Therefore, the availability of necessary logistics and training for employees with regular supportive supervision and monitoring should be conducted with the integration of sectors at the district and zone levels.
The Maternal and Infant Environmental Health Riskscape study of perinatal disparities in greater Houston: rationale, study design and participant profiles
Authors: Symanski Elaine , Whitworth Kristina W. , Mendez-Figueroa Hector , Aagaard Kjersti M. , Moussa Iman , Alvarez Juan , Chardon Fabian Adrien , Kannan Kurunthachalam , Walker Cheryl L. , Coarfa Cristian , Suter Melissa A. , Salihu Hamisu M. 
Published: April 2024

IntroductionThe Maternal and Infant Environmental Health Riskscape (MIEHR) Center was established to address the interplay among chemical and non-chemical stressors in the biological, physical, social, and built environments that disproportionately impact perinatal health among Black pregnant people in a large and diverse urban area with documented disparities in the U.S.MethodsThe MIEHR cohort is recruiting non-Hispanic Black and non-Hispanic white pregnant people who deliver their infants at major obstetric hospitals in Houston, Texas. At enrollment, all participants are asked to provide urine samples for chemical [metals, cotinine, and polycyclic aromatic hydrocarbons (PAHs)] analyses and blood samples. A subset of the cohort is asked to provide oral and vaginal swabs, and fecal samples. Questionnaire and electronic health record data gather information about residential address history during pregnancy, pregnancy history and prenatal care, sociodemographic and lifestyle factors, experiences of discrimination and stress, and sources of social support. Using information on where a participant lived during their pregnancy, features of their neighborhood environment are characterized. We provide summaries of key individual- and neighborhood-level features of the entire cohort, as well as for Black and white participants separately.ResultsBetween April 2021 and February 2023, 1,244 pregnant people were recruited. Nearly all participants provided urine samples and slightly less than half provided blood samples. PAH exposure patterns as assessed on 47% of participants thus far showed varying levels depending on metabolite as compared to previous studies. Additionally, analyses suggest differences between Black and white pregnant people in experiences of discrimination, stress, and levels of social support, as well as in neighborhood characteristics.DiscussionOur findings to date highlight racial differences in experiences of discrimination, stress, and levels of support, as well as neighborhood characteristics. Recruitment of the cohort is ongoing and additional neighborhood metrics are being constructed. Biospecimens will be analyzed for metals and PAH metabolites (urine samples), miRNAs (plasma samples) and the microbiome (oral swabs). Once enrollment ends, formal assessments are planned to elucidate individual- and neighborhood-level features in the environmental riskscape that contribute to Black-White disparities in perinatal health.
Precise micromotion compensation of a tilted ion chain
Authors: Hogle Craig W. , Burch Ashlyn D. , Sterk Jonathan D. , Chow Matthew N. H. , Ivory Megan , Lobser Daniel S. , Maunz Peter , Van Der Wall Jay , Yale Christopher G. , Clark Susan M. , Stick Daniel , Revelle Melissa C. 
Published: April 2024

Excess micromotion can be a substantial source of errors in trapped-ion based quantum processors and clocks due to the sensitivity of the internal states of the ion to external fields and motion. This problem can be fixed by compensating background electric fields in order to position ions at the RF node and minimize their driven micromotion. Here we describe techniques for compensating ion chains in scalable surface ion traps. These traps are capable of cancelling stray electric fields with fine spatial resolution in order to compensate multiple closely spaced ions due to their large number of relatively small control electrodes. We demonstrate a technique that compensates an ion chain to better than 5 V/m and within 0.1 degrees of chain rotation.
Strategic mapping of onion supply chains: a comprehensive analysis of production and post-harvest processes in Northwest Ethiopia
Authors: Yeshiwas Yebirzaf , Alemayehu Melkamu , Adgo Enyew 
Published: April 2024

IntroductionOnion is a significant vegetable crop in Ethiopia, serving as a source of income for smallholder farmers. However, various challenges in the production and post-harvest handling processes impede a consistent supply and marketing of the crop. This study focused on a comprehensive analysis of the onion supply chain, ranging from production to post-harvest handling, to address the existing production and marketing processes. The research initiative was undertaken to map the onion supply chain from farmers to consumers, intending to establish an improved marketing system in northwest Ethiopia.MethodsThe study area covered three onion-producing districts of the Amhara Region. Data collection involved interviews, observations, and market assessments using a structured questionnaire. Sampling followed a multistage technique. The analysis included descriptive statistics and food system analysis to map the supply chain and estimate marketing margins.Results and DiscussionPost-harvest loss in onion production presents a major obstacle in the farming sector, impacting its growth. The study identified six alternative channels for onion marketing where different actors are involved throughout the supply chain. Key stakeholders include farmers, local collectors, brokers, transporters, wholesalers, retailers, and consumers. Packaging and sorting activities are implemented at different supply chain stages to minimize post-harvest losses. Farm-level activities, including curing, sorting, grading, and ventilating, are crucial for reducing losses. The perishable nature of onion bulbs and the existing production and handling challenges exacerbate post-harvest losses. Efforts to address this challenge demand a comprehensive approach, integrating interventions across the value chain, from improved cultivars and storage infrastructure to enhanced market access strategies. Hence, stakeholders and governmental organizations are urged to promote onion value-addition technologies, including the establishment of processing industries. Such endeavors promote collaborative efforts across the onion supply chain, ensuring sustainable benefits for producers and traders.
Radiographic and clinical outcomes of robot-assisted pedicle screw instrumentation for adolescent idiopathic scoliosis
Authors: Chen Yuan-Shao , Lin Yu-Hsien , Wu Yun-Che , Shih Cheng-Min , Chen Kun-Huei , Lee Cheng-Hung , Lu Wen-Hsien , Pan Chien-Chou 
Published: April 2024

IntroductionPedicle screw instrumentation (PSI) serves as the widely accepted surgical treatment for adolescent idiopathic scoliosis (AIS). The accuracy of screw positioning has remarkably improved with robotic assistance. Nonetheless, its impact on radiographic and clinical outcomes remains unexplored. This study aimed to investigate the radiographic and clinical outcomes of robot-assisted PSI vs. conventional freehand method in AIS patients.MethodsData of AIS patients who underwent PSI with all pedicle screws between April 2013 and March 2022 were included and retrospectively analyzed; those with hybrid implants were excluded. Recruited individuals were divided into the Robot-assisted or Freehand group according to the technique used. Radiographic parameters and clinical outcome measures were documented.ResultsIn total, 50 patients (19, Freehand group; 31, Robot-assisted group) were eligible, with an average age and follow-up period of 17.6 years and 60.2 months, respectively, and female predominance (40/50, 80.0%). The correction rates of Cobb's angles for both groups were significant postoperatively. Compared to freehand, the robot-assisted technique achieved a significantly reduced breech rate and provided better trunk shift and radiographic shoulder height correction with preserved lumbar lordosis, resulting in significantly improved visual analog scale scores for back pain from the third postoperative month.ConclusionOverall, robot-assisted PSI provides satisfactory radiographic and clinical outcomes in AIS patients.