bluuebunny/crossref_metadata_2025_split huggingface dataset:
Luminescence Resonance Energy Transfer in Heterodinuclear LnIII Complexes for Sensing Biologically Relevant Anions
Authors: Andolina Christopher M. , Morrow Janet R. 
Published: November 2010

AbstractDinuclear lanthanide(III) complexes of the macrocycles 1,4‐bis[1‐4,7,10‐ tris(carbamoylmethyl)‐1,4,7,10‐tetraazacyclododecane]‐m‐xylene (1) and 1,3‐bis[1‐4,7,10‐tris(carbamoylmethyl)‐1,4,7,10‐tetraazacyclododecane]‐p‐xylene (2) with LnIII = EuIII, TbIII were prepared. Studies using direct excitation (7F0 → 5D0) europium(III) luminescence spectroscopy show that several anions including phosphate, methylphosphate, double‐stranded DNA, a DNA hairpin loop, and fluoride bind to both EuIII centers in Eu2(1) in solutions at pH 7.0, 0.100 M NaNO3. Recovered luminescence lifetime data is consistent with replacement of water ligands by these anions. There are distinct changes in the relative intensities of EuIII emission peaks for complexes of Eu2(1) and Eu2(2) with phosphate, fluoride, carbonate, and phosphate ester ligands. This suggests that the EuIII dinuclear complexes show promise as ratiometric sensors for these anions. In contrast, the emission peak ratios for the Tb2(1) and Tb2(2) complex show a lower response upon binding of each anionic ligand. Luminescence resonance energy transfer (LRET) studies with mixed EuIII/NdIII complexes show that the phosphate complexes of Ln2(1) or Ln2(2) both have LnIII–LnIII internuclear distances of 7.7 ± 0.9 Å and the methylphosphate complexes of Ln2(1) and Ln2(2) have internuclear distances of 7.8 ± 0.6 and 8.0 ± 0.7 Å, respectively. LRET experiments also show the two lanthanide ion centers in Ln2(2) are 8.4 ± 0.5 Å apart when bound to GC rich duplex DNA. None of the other anions (carbonate, fluoride, DNA hairpins) form complexes that show measurable energy transfer between the lanthanide ions, which is consistent with intranuclear distances >8 Å.
Syntheses, Characterization and Properties of Open‐Chain Copper(I) Complexes
Authors: Utz Diana , Kisslinger Sandra , Heinemann Frank W. , Hampel Frank , Schindler Siegfried 
Published: November 2010

AbstractThe coordination chemistry of copper complexes with theligand L1 [L1 = {7E}‐N1‐benzylidene‐N2‐{(E)‐2‐(benzylideneamino)ethyl}ethane‐1,2‐diamine] has been investigated. For copper(I) complexes of L1, the counterion determines the molecular structure in the solid state. The reaction of [Cu(CH3CN)4]PF6 with L1 yielded the mononuclear complex [Cu(L1)(CH3CN)]PF6 (1), whereas dinuclear helical [Cu2(L1)2](ClO4)2 (2) resulted from a similar reaction with [Cu(CH3CN)4]ClO4. Both compounds have been structurally characterized, and their solution behaviour investigated. Structurally characterized [Cu(L1)(PPh3)]ClO4 (3) has been synthesized by reacting 2 with PPh3. Exposure of a solution of 1 towards dioxygen in CH3OH and CH2Cl2 yielded the dinuclear complexes [Cu2(L1)2(OCH3)2](PF6)2 (4) and [Cu2(L1)2(OH)2](PF6)2 (5), respectively. Both compounds have been fully characterized. During the oxidation reaction, no hydroxylation of L1 occurred. The oxidation reaction of 1 has been studied by a chemical approach and by UV/Vis spectroscopy, indicating the formation of a peroxido‐bridged species during the reaction. Furthermore, by reduction of the imine groups in L1 the ligand L2 [L2 = N1‐benzyl‐N2‐{2‐(benzylamino)ethyl}ethane‐1,2‐diamine] was obtained and the dinuclear copper(II) complex [Cu2(L2)2Cl3]PF6·2MeOH (6) has been structurally characterized.
Synthesis of S‐Acetyl Oligo‐p‐aryleneethynylene Tetrathiols
Authors: Hassan Omar Omar , Babudri Francesco , Farinola Gianluca M. , Naso Francesco , Operamolla Alessandra 
Published: November 2010

AbstractA novel class of tetrathiolated aryleneethynylene oligomers was obtained by the Cassar–Heck–Sonogashira coupling between S,S′‐(5‐ethynyl‐1,3‐phenylene)bis(methylene)diethanethioate (1) and aryl diiodides or dibromides. Although standard coupling conditions are effective in the case of iodo derivatives, the addition of free triphenylphosphane to the reaction mixture was required to overcome the slower reaction rate of dibromoarenes. Oligomers with an extended conjugated system could be obtained starting from a higher homologue of 1 by applying the same synthetic approach. These oligomers represent interesting molecular wires, potentially able to self‐assemble on various substrates, including gold and other noble metals in the form of thin films or nanoparticles. The chelating arrangement of the thiol functionalities should ensure stable anchoring and would also represent an interesting novel feature in the study of single molecule conduction with respect to traditional monodentate systems.
Micellar electrokinetic chromatography: A practical overview of current methodological and instrumental advances
Authors: Silva Manuel 
Published: November 2010

AbstractThis review highlights recent methodological and instrumental advances in MEKC focused on the improvement of this CE technique in routine analyses. As in the previous reviews, the present one deals with the last 2 years' most relevant methodological contributions for improving sensitivity and resolution in MEKC as well as instrumental research related to MS and LIF detection. The most widespread approaches are discussed in detail, including enhancements in sensitivity arising from the use of on‐line sample concentration (stacking, sweeping, and a combination of both of these protocols) and improvements in resolution, obtained by changing the composition of the BGE (e.g. with additives to the aqueous phase or employing alternative micellar phases to classical SDS) and using 2‐D separation systems. The advantages and restrictions in MS and LIF detection as applied to MEKC analysis are also examined, especially in the direct coupling of MEKC and MS detection. Finally, some thoughts on potential future directions are also considered.
Measuring and interpreting expectations of equity returns
Authors: Dominitz Jeff , Manski Charles F. 
Published: November 2010

AbstractWe analyze probabilistic expectations of equity returns elicited in the Survey of Economic Expectations in 1999–2001 and in the Michigan Survey of Consumers in 2002–2004. Our empirical findings suggest that individuals use interpersonally variable but intrapersonally stable processes to form their expectations. We therefore propose to think of the population as a mixture of expectations types, each forming expectations in a stable but different way. We use our expectations data to learn about the prevalence of several specific types suggested by research in finance. Copyright © 2010 John Wiley & Sons, Ltd.
The Recognition and Assessment of Cardiovascular Risk in People with Rheumatoid Arthritis in Primary Care: A Questionnaire‐Based Study of General Practitioners
Authors: Bell Carolyn , Rowe Ian F. 
Published: November 2010

AbstractObjectives. To investigate how well recognized the association between rheumatoid arthritis (RA) and excess cardiovascular (CV) risk is within primary care and the current assessment strategies being employed by general practitioners (GPs).Methods. Questionnaires were sent to all 376 GPs in the Worcestershire Primary Care Trust.Results. Thirty‐two per cent of GPs identified RA as an independent risk factor for CV disease. Fifteen per cent and 34%, respectively, assessed their RA patients for primary and secondary prevention of their CV risks. Of those GPs who made an assessment, 18.4% adjusted the calculated risk derived from standard charts. The frequency of assessment was greater among GPs who had received a form of education about the association between CV disease and RA. However, of the GPs identifying this susceptibility, only 40% performed any form of primary prevention risk assessment.Conclusions. At present, the excess risk of CV disease conferred by RA is under‐recognized and under‐assessed in primary care. Currently, educational resources on this topic targeted at GPs are lacking and may in part account for our findings. However, even when GPs did identify the risk of CV disease in RA or had received education about it, this did not consistently change their clinical management. Further work to promote knowledge and management strategies for CV disease in RA is therefore needed to improve the care of patients with this condition.Copyright © 2010 John Wiley & Sons, Ltd.
Photovoltaics literature survey (no. 82)
Authors: Shrestha Santosh 
Published: November 2010

AbstractIn order to help keep readers up‐to‐date in the field each issue of Progress in Photovoltaics will contain a list of recently published journal articles most relevant to its aims and scope. This list is drawn from an extremely wide range of journals, including IEEE Transactions on Electron Devices, Journal of Applied Physics, Applied Physics Letters, Progress in Photovoltaics and Solar Energy Materials and Solar Cells. To assist the reader, the list is separated into broad categories, but please note that these classifications are by no means strict. Also note that inclusion in the list is not an endorsement of a paper's quality. Copyright © 2010 John Wiley & Sons, Ltd.
Shotgun proteomic profiling of five species of New ZealandPachycladon
Authors: Mirzaei Mehdi , Pascovici Dana , Keighley Tim , George Iniga , Voelckel Claudia , Heenan Peter B. , Haynes Paul A. 
Published: November 2010

AbstractThe genusPachycladonconsists of ten species of alpine plants, nine of which are endemic to New Zealand. The species are closely related to the model plantArabidopsis thalianawith respect to their sequence divergence and chromosome synteny, occupy distinct geographical habitats in terms of both latitude and altitude, and display a range of morphologies. We have performed label‐free quantitative shotgun proteomic analysis of five different species ofPachycladon, namelyP. cheesemanii(CH),P. exile(EX),P. fastigiatum(FA),P. enysii(EN) andP. novae‐zelandiae(NZ). The total non‐redundant data set for all five species contained 1489 proteins. The numbers of proteins identified reproducibly in each species ranged from 629 for CH to 987 for NZ, with 681 for EN, 741 for EX and 934 for FA. Previous metabolite‐based studies have shown that FA hydrolyzes glucosinolates completely to isothiocyanates while EN converts glucosinolates to nitriles. In this study, we observed high expression of ESP (At1g54040, epithiospecifying senescence regulator protein) and myrosinase 2 (At5g25980, glycosyl hydrolase family protein), which result in production of nitriles and epithionitriles, in EN and NZ, and we also observed higher expression of ESM1 (At3g14210, GDSL esterase/lipase), which mediates the formation of isothiocyanate, in FA.
Increased oxidative‐modifications of cytosolic proteins in 3,4‐methylenedioxymethamphetamine (MDMA, ecstasy)‐exposed rat liver
Authors: Upreti Vijay V. , Moon Kwan‐Hoon , Yu Li‐Rong , Lee Insong J. , Eddington Natalie D. , Ye Xiaoying , Veenstra Timothy D. , Song Byoung‐Joon 
Published: November 2010

AbstractIt is well established that 3,4‐methylenedioxymethamphetamine (MDMA, ecstasy) causes acute liver damage in animals and humans. The aim of this study was to identify and characterize oxidative modification and inactivation of cytosolic proteins in MDMA‐exposed rats. Markedly increased levels of oxidized and nitrated cytosolic proteins were detected 12 h after the second administration of two consecutive MDMA doses (10 mg/kg each). Comparative 2‐DE analysis showed markedly increased levels of biotin‐N‐methylimide‐labeled oxidized cytosolic proteins in MDMA‐exposed rats compared to vehicle‐treated rats. Proteins in the 22 gel spots of strong intensities were identified using MS/MS. The oxidatively modified proteins identified include anti‐oxidant defensive enzymes, a calcium‐binding protein, and proteins involved in metabolism of lipids, nitrogen, and carbohydrates (glycolysis). Cytosolic superoxide dismutase was oxidized and its activity significantly inhibited following MDMA exposure. Consistent with the oxidative inactivation of peroxiredoxin, MDMA activated c‐JunN‐terminal protein kinase and p38 kinase. Since these protein kinases phosphorylate anti‐apoptotic Bcl‐2 protein, their activation may promote apoptosis in MDMA‐exposed tissues. Our results show for the first time that MDMA induces oxidative‐modification of many cytosolic proteins accompanied with increased oxidative stress and apoptosis, contributing to hepatic damage.
Proteomic analysis of the anti‐inflammatory action of minocycline
Authors: Dunston Christopher R. , Griffiths Helen R. , Lambert Peter A. , Staddon Susan , Vernallis Ann B. 
Published: November 2010

AbstractMinocycline possesses anti‐inflammatory properties independently of its antibiotic activity although the underlying molecular mechanisms are unclear. Lipopolysaccharide (LPS)‐induced cytokines and pro‐inflammatory protein expression are reduced by minocycline in cultured macrophages. Here, we tested a range of clinically important tetracycline compounds (oxytetracycline, doxycycline, minocycline and tigecycline) and showed that they all inhibited LPS‐induced nitric oxide production. We made the novel finding that tigecycline inhibited LPS‐induced nitric oxide production to a greater extent than the other tetracycline compounds tested. To identify potential targets for minocycline, we assessed alterations in the macrophage proteome induced by LPS in the presence or absence of a minocycline pre‐treatment using 2‐DE and nanoLC‐MS. We found a number of proteins, mainly involved in cellular metabolism (ATP synthase β‐subunit and aldose reductase) or stress response (heat shock proteins), which were altered in expression in response to LPS, some of which were restored, at least in part, by minocycline. This is the first study to document proteomic changes induced by minocycline. The observation that minocycline inhibits some, but not all, of the LPS‐induced proteomic changes shows that minocycline specifically affects some signalling pathways and does not completely inhibit macrophage activation.
Quantitative protein determination for CYP induction via LC‐MS/MS
Authors: Williamson Brian L. , Purkayastha Subhasish , Hunter Christie L. , Nuwaysir Lydia , Hill James , Easterwood LaHoma , Hill Jeanette 
Published: November 2010

AbstractThe Cytochrome P450 (CYP) proteins are a family of membrane bound proteins that function as a major metabolizing enzyme in the human body. Quantification of CYP induction is critical in determining the disposition, safety and efficacy of drugs in humans. Described is a gel‐free, high‐throughput LC‐MS approach to quantitate the CYP isoforms 1A2, 2B6, 3A4 and 3A5 by measuring isoform specific peptides released by enzymatic digestion of the hepatocyte incubations. The method uses synthetic stable isotope‐labeled peptides as internal standards and allows both relative and absolute quantification to be performed from hepatic microsomal preparations. CYP protein determined by this LC‐MS method correlated well with the mRNA and activity for induced levels of CYP1A2, CYP2B6 and CYP3A4. Interestingly, a small fold change was observed for the induction of 3A5 with phenobarbital. The results were reproducible with an average CV less then 10% for repeat analysis of the sample. This LC‐MS method offers a robust assay for CYP protein quantitation for use in CYP induction assays
Multi‐cause degradation path model: a case study on rubidium lamp degradation
Authors: Quan Sun , Kvam Paul H. 
Published: November 2010

AbstractAt the core of satellite rubidium standard clocks is the rubidium lamp, which is a critical piece of equipment in a satellite navigation system. There are many challenges in understanding and improving the reliability of the rubidium lamp, including the extensive lifetime requirement and the dearth of samples available for destructive life tests. Experimenters rely on degradation experiments to assess the lifetime distribution of highly reliable products that seem unlikely to fail under the normal stress conditions, because degradation data can provide extra information about product reliability. Based on recent research on the rubidium lamp, this article presents a multi‐cause degradation path model, including its application background, model description, modeling method, and parameter estimation method. Using the available data from degradation tests, we construct point estimates and interval estimates for rubidium lamp lifetimes using regression techniques. Copyright © 2010 John Wiley & Sons, Ltd.
Sensor and actuator fault diagnosis for wind turbine systems by using robust observer and filter
Authors: Wei X. , Verhaegen M. 
Published: November 2010

AbstractIn this paper, we consider sensor and actuator fault detection and estimation issues for large scale wind turbine systems where individual pitch control (IPC) is used for load reduction. The faults considered are the blade root bending moment sensor faults and blade pitch actuator faults. In the first part, with the aid of a dynamical model of the wind turbine system, a so‐called H∞/H− observer in the finite frequency range, is applied to generate the residual for fault detection. The observer is designed to be sensitive to faults but insensitive to disturbances, such as wind turbulence. When there is a detectable fault, the observer sends an alarm signal if the residual evaluation is larger than a predefined threshold. In addition to the fault detection, we also consider the fault estimation problem, where a dynamic filter is used to estimate the fault magnitude. The effectiveness of the proposed approach is demonstrated by simulation results for several fault scenarios. Copyright © 2010 John Wiley & Sons, Ltd.
A Polymeric Arched Chain and a Chair‐like M2L2‐Metallamacrocycle Crystal Engineered of [M(phen)]2+ (M = Cu, Cd; phen = 1,10‐Phenanthroline) Corner Units and the Bent Ligand 4,4′‐Dithiodipyridine
Authors: Seidel Rüdiger W. , Dietz Christina , Oppel Iris M. 
Published: November 2010

AbstractSelf‐assembly of Cd(phen)2+ and Cu(phen)2+ (phen = 1,10‐phenanthroline) building blocks with the bent ligand 4,4′‐dithiodipyridine (dtdp) has been investigated. Both building blocks serve as corner units with constrained cis‐geometry. The arched chain coordination polymer [{Cd(phen)(μ‐dtdp)(dtdp)(H2O)}(ClO4)2·2CH3OH·1.5H2O]n (1) crystallised from a mixture of Cd(ClO4)2·H2O, phen and dtdp in methanol. The reaction of [Cu(phen)(H2O)2](CF3SO3)2 (2) with dtdp in an ethanol/water mixture yielded a chair‐like metallamacrocycle, [{Cu(phen)(CF3SO3)2}2(μ‐dtpd)2] (3). The crystal structure of the precursor complex 2 is also reported.
Syntheses and Characterizations of two Zinc(II) Metal‐organic Frameworks based on 1,4‐Naphthalenedicarboxylate and Imidazole Ligands
Authors: Wang Jingyuan , You Hongpeng 
Published: November 2010

AbstractTwo new compounds, namely [Zn(1,4‐ndc)(L1)] (1), and [Zn(1,4‐ndc)(L2)]·0.25H2O (2) [L1 = 2‐phenylimidazole, L2 = 1,1′‐(1,4‐butanediyl)bis(imidazole), and 1,4‐ndc = 1,4‐naphthalenedicarboxylate] were successfully synthesized under similar hydrothermal conditions. In compound 1, each 1,4‐ndc anion links two neighboring ZnII cations with its carboxylate groups to generate a 2D layer structure. The L1 ligands are attached on both sides of the layers. In compound 2, each carboxylate group of 1,4‐ndc connects one ZnII atom in monodentate mode to form a 1D zigzag chain. Further, the L2 ligands link the chains to generate an expanded diamond net. Four diamond networks interweave to form a 3D interpenetrating diamond framework in an unusual [2+2] mode. Furthermore, the title compounds exhibit good luminescent properties in the range from ultraviolet to visible light and may find potential applications as fluorescent materials.
[Be3(μ3‐O)3(MeCN)6{Be(MeCN)3}3](I)6 – ein Berylliumkomplex mit Cyclo‐(Be3O3)‐Kern und sein Hydrolyseprodukt [Be(H2O)4](I)2·2MeCN
Authors: Puchta Ralph , Neumüller Bernhard , Dehnicke Kurt 
Published: November 2010

AbstractSingle crystals of [Be3(μ3‐O)3(MeCN)6{Be(MeCN)3}3](I)6·4CH3CN (1·4CH3CN) were obtained in low yield by the reaction of beryllium powder with iodine in acetonitrile suspension, which probably result from traces of beryllium oxide containing the applied beryllium metal. The compound 1·4CH3CN forms moisture sensitive, colourless crystal needles, which were characterized by IR spectroscopy and X‐ray diffraction (Space group Pnma, Z = 4, lattice dimensions at 100(2) K: a = 2317.4(1), b = 2491.4(1), c = 1190.6(1) pm, R1 = 0.0315). The hexaiodide complex cation 16+consists of a cyclo‐Be3O3 core with slightly distorted chair conformation, stabilized by coordination of two acetonitrile ligands at each of the beryllium atoms and by a {Be(CH3CN)3}2+ cation at each of the oxygen atoms. This unique coordination behaviour results in coplanar OBe3 units with short Be–O distances of 155.0 pm and 153.6 pm on average of bond lengths within the cyclo‐Be3O3 unit and of the peripheric BeO bonds, respectively. Exposure of compound 1·4CH3CN to moist air leads to small orange crystal plates of [Be(H2O)4]I2·2CH3CN (3·2CH3CN). According to the crystal structure determination (Space group C2/c, Z = 4, lattice dimensions at 100(2) K: a = 1220.7(1), b = 735.0(1), c = 1608.5(1) pm, β = 97.97(1)°, R1 = 0.0394), all hydrogen atoms of the dication [Be(H2O)4]2+ are involved to form O–H···N and O–H···I hydrogen bonds with the acetonitrile molecules and the iodide ions, respectively. Quantum chemical calculations (B3LYP/6‐311+G**) at the model [Be3(μ3‐O)3(HCN)6{Be(HCN)3}3]6+ show that chair and boat conformation are stable and that the distorted chair conformation is stabilized by packing effects.
Modularizing communication middleware concerns using aspects
Authors: Maffort Cristiano Amaral , Valente Marco Tulio de Oliveira 
Published: November 2010

AbstractSoftware engineers often rely on communication middleware platforms to design and implement distributed systems. However, middleware functionality is usually invasive, pervasive and tangled with business-specific concerns. In this paper, we describe an aspect-oriented distributed programming system that encapsulates middleware services provided by Java RMI and Java IDL. The proposed system, called DAJ, handles the basic service provided by such object-oriented middleware platforms, i.e., synchronous remote calls using call by-serialization and call by-remote-reference semantics. The paper documents our experience in using DAJ to modularize middleware concerns from three legacy distributed systems.
Brown‐Vialetto‐Van Laere and Fazio Londe syndrome is associated with a riboflavin transporter defect mimicking mild MADD: a new inborn error of metabolism with potential treatment
Authors: Bosch Annet M. , Abeling Nico G. G. M. , IJlst Lodewijk , Knoester Hennie , van der Pol W. Ludo , Stroomer Alida E. M. , Wanders Ronald J. , Visser Gepke , Wijburg Frits A. , Duran Marinus , Waterham Hans R. 
Published: November 2010

AbstractWe report on three patients (two siblings and one unrelated) presenting in infancy with progressive muscle weakness and paralysis of the diaphragm. Metabolic studies revealed a profile of plasma acylcarnitines and urine organic acids suggestive of a mild form of the multiple acyl‐CoA dehydrogenation defect (MADD, ethylmalonic/adipic acid syndrome). Subsequently, a profound flavin deficiency in spite of a normal dietary riboflavin intake was established in the plasma of all three children, suggesting a riboflavin transporter defect. Genetic analysis of these patients demonstrated mutations in the C20orf54 gene which encodes the human homolog of a rat riboflavin transporter. This gene was recently implicated in the Brown‐Vialetto‐Van Laere syndrome, a rare neurological disorder which may either present in infancy with neurological deterioration with hypotonia, respiratory insufficiency and early death, or later in life with deafness and progressive ponto‐bulbar palsy. Supplementation of riboflavin rapidly improved the clinical symptoms as well as the biochemical abnormalities in our patients, demonstrating that high dose riboflavin is a potential treatment for the Brown‐Vialetto‐Van Laere syndrome as well as for the Fazio Londe syndrome which is considered to be the same disease entity without the deafness.