bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficient identification of broad absorption line quasars using dimensionality reduction and machine learning
Authors: Kao Wei-Bo , Zhang Yanxia , Wu Xue-Bing 
Published: May 2024

Abstract
Broad Absorption Line Quasars (BALQSOs) represent a significant phenomenon in the realm of quasar astronomy, displaying distinct blueshifted broad absorption lines. These enigmatic objects serve as invaluable probes for unraveling the intricate structure and evolution of quasars, shedding light on the profound influence exerted by supermassive black holes on galaxy formation. The proliferation of large-scale spectroscopic surveys such as LAMOST (the Large Sky Area Multi-Object Fiber Spectroscopic Telescope), SDSS (the Sloan Digital Sky Survey), and DESI (the Dark Energy Spectroscopic Instrument) has exponentially expanded the repository of quasar spectra at our disposal. In this study, we present an innovative approach to streamline the identification of BALQSOs, leveraging the power of dimensionality reduction and machine-learning algorithms. Our dataset is meticulously curated from the SDSS Data Release 16 (DR16), amalgamating quasar spectra with classification labels sourced from the DR16Q quasar catalog. We employ a diverse array of dimensionality-reduction techniques, including principal component analysis (PCA), t-Distributed stochastic neighbor embedding (t-SNE), locally linear embedding (LLE), and isometric mapping (ISOMAP), to distill the essence of the original spectral data. The resultant low-dimensional representations serve as inputs for a suite of machine-learning classifiers, including the robust XGBoost and Random Forest models. Through rigorous experimentation, we unveil PCA as the most effective dimensionality-reduction methodology, adeptly navigating the intricate balance between dimensionality reduction and preservation of vital spectral information. Notably, the synergistic fusion of PCA with the XGBoost classifier emerges as the pinnacle of efficacy in the BALQSO classification endeavor, boasting impressive accuracy rates of $97.60\%$ by 10-cross validation and $96.92\%$ on the outer test sample. This study not only introduces a novel machine-learning-based paradigm for quasar classification but also offers invaluable insights transferrable to a myriad of spectral classification challenges pervasive in the realm of astronomy.
Association of back pain with all-cause and cause-specific mortality among older men: a cohort study
Authors: Roseen Eric J , McNaughton David T , Harrison Stephanie , Downie Aron S , Øverås Cecilie K , Nim Casper G , Jenkins Hazel J , Young James J , Hartvigsen Jan , Stone Katie L , Ensrud Kristine E , Lee Soomi , Cawthon Peggy M , Fink Howard A 
Published: May 2024

Abstract

Objective
We evaluated whether more severe back pain phenotypes—persistent, frequent, or disabling back pain—are associated with higher mortality rate among older men.

Methods
In this secondary analysis of a prospective cohort, the Osteoporotic Fractures in Men (MrOS) study, we evaluated mortality rates by back pain phenotype among 5215 older community-dwelling men (mean age, 73 years, SD = 5.6) from 6 sites in the United States. The primary back pain measure used baseline and Year 5 back pain questionnaire data to characterize participants as having no back pain, nonpersistent back pain, infrequent persistent back pain, or frequent persistent back pain. Secondary measures of back pain from the Year 5 questionnaire included disabling back pain phenotypes. The main outcomes measured were all-cause and cause-specific death.

Results
After the Year 5 exam, during up to 18 years of follow-up (mean follow-up = 10.3 years), there were 3513 deaths (1218 cardiovascular, 764 cancer, 1531 other). A higher proportion of men with frequent persistent back pain versus no back pain died (78% versus 69%; sociodemographic-adjusted HR = 1.27, 95% CI = 1.11–1.45). No association was evident after further adjustment for health-related factors, such as self-reported general health and comorbid chronic health conditions (fully adjusted HR = 1.00; 95% CI = 0.86–1.15). Results were similar for cardiovascular deaths and other deaths, but we observed no association of back pain with cancer deaths. Secondary back pain measures, including back-related disability, were associated with increased mortality risk that remained statistically significant in fully adjusted models.

Conclusion
Although frequent persistent back pain was not independently associated with risk of death in older men, additional secondary disabling back pain phenotypes were independently associated with increased mortality rate. Future investigations should evaluate whether improvements in disabling back pain affect general health and well-being or risk of death.
Marital violence affects reproductive health and pregnancy outcomes in Northeast India
Authors: Haobijam Sharatchandra , Singh Kshetrimayum Anand 
Published: May 2024

Abstract

Background
As per the National Family Health Survey (NFHS-4, 2015–16) report, 40% of women aged 15–49 in India experienced intimate partner violence (IPV), with emotional abuse significantly associated with negative reproductive health (RH) outcomes.

Methods
The study uses secondary data from the NFHS-4 and conducts statistical analysis based on information gathered from 8766 married women aged 15–49 years in Northeast India. Bivariate analysis followed by multiple logistic regression analysis is performed to understand the relationship between IPV and its effects on women’s RH.

Results
The findings indicate that ever-married women in Northeast India have faced physical violence (25.1%), sexual violence (11.8%), emotional abuse (6.4%) and severe violence (5.3%). Among all women who participated in the study, 6.9% had experienced non-live births, 4.2% miscarriages, 2.4% abortions, 0.3% stillbirths, 16.9% terminated pregnancies and 2.1% sexually transmitted infections (STI). Sexually abused women (SAW) showed higher likelihoods of non-live births, STIs, miscarriages, abortions and pregnancy terminations. SAW had a 65% higher risk of miscarriages, while those experiencing physical violence had a 64% increased risk of abortions.

Conclusion
IPV significantly impacts women’s RH in Northeast India. This study presents evidence from surveys on sexual and RH among married women affected by IPV in Northeast India.
Efficient and Convergent Sequential Pseudo-Likelihood Estimation of Dynamic Discrete Games
Authors: Dearing Adam , Blevins Jason R 
Published: May 2024

Abstract
We propose a new sequential Efficient Pseudo-Likelihood (k-EPL) estimator for dynamic discrete choice games of incomplete information. k-EPL considers the joint behaviour of multiple players simultaneously, as opposed to individual responses to other agents’ equilibrium play. This, in addition to reframing the problem from conditional choice probability (CCP) space to value function space, yields a computationally tractable, stable, and efficient estimator. We show that each iteration in the k-EPL sequence is consistent and asymptotically efficient, so the first-order asymptotic properties do not vary across iterations. Furthermore, we show the sequence achieves higher-order equivalence to the finite-sample maximum-likelihood estimator with iteration and that the sequence of estimators converges almost surely to the maximum-likelihood estimator at a nearly superlinear rate when the data are generated by any regular Markov perfect equilibrium, including equilibria that lead to inconsistency of other sequential estimators. When utility is linear in parameters, k-EPL iterations are computationally simple, only requiring that the researcher solve linear systems of equations to generate pseudo-regressors which are used in a static logit/probit regression. Monte Carlo simulations demonstrate the theoretical results and show k-EPL’s good performance in finite samples in both small- and large-scale games, even when the game admits spurious equilibria in addition to one that generated the data. We apply the estimator to analyse competition in the U.S. wholesale club industry.
Psychological distress over 12 months post-diagnosis in an early inflammatory arthritis cohort
Authors: Zhao Lucy , Galloway James , Ledingham Jo , Gallagher Sarah , Garnavos Gerasimina , Amlani-Hatcher Paul , Wilson Nicky , Carpenter Lewis , Bannister Kirsty , Norton Sam 
Published: May 2024

Abstract

Objectives
People with inflammatory arthritis (IA) experience worsened mental wellbeing alongside disease progression. Using the National Early Inflammatory Arthritis Audit (NEIAA), we assessed trends in psychological distress during the 12 months following IA diagnosis, mapping these against clinical outcomes to identify associations.

Methods
This is a prospective study of people recruited to NEIAA receiving an IA diagnosis and completing the baseline patient survey. Patient-reported outcomes (PROs) at baseline, 3 months and 12 months were collected, including psychological distress [assessed using Patient Health Questionnaire Anxiety and Depression Screener (PHQ4ADS)]. Mixed effects linear regression models estimated associations between predictor variables with psychological distress at baseline and over time.

Results
Of 6873 eligible patients, 3451 (50.2%) showed psychological distress at baseline. Of those completing follow-ups, 30.0% and 24.1% were distressed at 3 months and 12 months, respectively. Higher psychological distress at diagnosis was more commonly reported by younger, female and non-White patients. Clinical factors, including higher counts of comorbidities, prior depression and higher disease activity at diagnosis were associated with higher distress. Higher distress at baseline was associated with poorer outcomes over time in quality of life, disability, work performance, disease activity, as well as reduced likelihood of achieving good treatment response by EULAR criteria.

Conclusion
Half of patients with IA show significant mental health comorbidity at presentation, which associated with worse disease outcomes and quality of life. Screening for anxiety and depression should be a universal standard, and access to effective mood therapies alongside arthritis treatments is essential. Strategies should be culturally valid and consider multi-morbidities.
Whole transcriptome sequencing reveals the activity of the PLA2 family members in Androctonus crassicauda (Scorpionida: Buthidae) venom gland
Authors: Salabi Fatemeh , Jafari Hedieh 
Published: May 2024

AbstractPhospholipase A2 is the most abundant venom gland enzyme, whose activity leads to the activation of the inflammatory response by accumulating lipid mediators. This study aimed to identify, classify, and investigate the properties of venom PLA2 isoforms. Then, the present findings were confirmed by chemically measuring the activity of PLA2. The sequences representing PLA2 annotation were extracted from the Androctonus crassicauda transcriptome dataset using BLAS searches against the local PLA2 database. We found several cDNA sequences of PLA2 classified and named by conducting multiple searches as platelet‐activating factor acetylhydrolases, calcium‐dependent PLA2s, calcium‐independent PLA2s, and secreted PLA2s. The largest and smallest isoforms of these proteins range between approximately 70.34 kDa (iPLA2) and 17.75 kDa (cPLA2). Among sPLA2 isoforms, sPLA2GXIIA and sPLA2G3 with ORF encoding 169 and 299 amino acids are the smallest and largest secreted PLA2, respectively. These results collectively suggested that A. crassicauda venom has PLA2 activity, and the members of this protein family may have important biological roles in lipid metabolism. This study also revealed the interaction between members of PLA2s in the PPI network. The results of this study would greatly help with the classification, evolutionary relationships, and interactions between PLA2 family proteins in the gene network.
Perioperative anaphylaxis: updates on pathophysiology
Authors: Jordan Justin , Levy Jerrold H. , Gonzalez-Estrada Alexei 
Published: May 2024

Purpose of reviewPerioperative anaphylaxis has historically been attributed to IgE/FcεRI-mediated reactions; there is now recognition of allergic and nonallergic triggers encompassing various reactions beyond IgE-mediated responses. This review aims to present recent advancements in knowledge regarding the mechanisms and pathophysiology of perioperative anaphylaxis.Recent findingsEmerging evidence highlights the role of the mast-cell related G-coupled protein receptor X2 pathway in direct mast cell degranulation, shedding light on previously unknown mechanisms. This pathway, alongside traditional IgE/FcεRI-mediated reactions, contributes to the complex nature of anaphylactic reactions. Investigations into the microbiota-anaphylaxis connection are ongoing, with potential implications for future treatment strategies. While serum tryptase levels serve as mast cell activation indicators, identifying triggers remains challenging. A range of mediators have been associated with anaphylaxis, including vasoactive peptides, proteases, lipid molecules, cytokines, chemokines, interleukins, complement components, and coagulation factors.SummaryFurther understanding of clinical endotypes and the microenvironment where anaphylactic reactions unfold is essential for standardizing mediator testing and characterization in perioperative anaphylaxis. Ongoing research aims to elucidate the mechanisms, pathways, and mediators involved across multiple organ systems, including the cardiovascular, respiratory, and integumentary systems, which will be crucial for improving patient outcomes.
Where Do We Go From Here? An Inventory of Publicly Available Data About Educator Academies, Medical Education Departments, and Offices of Medical Education
Authors: Kerns Stephanie C. , Beck Dallaghan Gary L. , Borges Nicole J. , Huggett Kathryn N. 
Published: May 2024

Abstract
With the recent widespread growth and interest among medical educators, analysis of how departments of medical education are structured and their intersection with existing structures within the same institution, such as an office of medical education and/or academy of educators, is warranted. Based on a review of the literature, the authors determined there was a need for an inventory of what medical schools have to offer their faculty, whether it be an office, an academy, or a department. This project sought to inventory the current structures of medical education departments, offices, and academies at U.S. medical schools to explore reporting structure, functions, and characteristics of these entities. Data were extracted from A Snapshot of Medical Student Education in the United States and Canada: Reports From 145 Schools, published in 2020 in the journal Academic Medicine, for each reporting institution. This led to exploration of medical school websites to catalogue institutional structures. Data collected in this inventory demonstrate the range of structures used by medical schools to offer faculty support for their work as teachers and educational researchers. The hypothesis was that departments of medical education would be the least prevalent structures identified in U.S. medical schools, which was indeed a finding. Although the search yielded considerable data for the inventory, there is a dearth of published literature describing current models and characteristics of these different entities. Significant difficulties were encountered locating information clearly delineating roles and responsibilities of each entity on many medical schools’ public-facing web pages. Findings are significant because they underscore the challenges medical education leaders have in obtaining information to research, compare, select, and design the administrative model(s) best suited to support faculty educators at their institution. Future work should include creating a detailed catalogue with descriptive information supplied by schools.
Interventions aiming to improve advance care planning uptake in oncology: a scoping review of recent randomized controlled trials
Authors: Libert Yves , Langhendries Caroline , Choucroun Lisa , Merckaert Isabelle 
Published: May 2024

Purpose of review
The evidence regarding the effectiveness of interventions aiming to improve ACP uptake appears mixed. The purpose of this scoping review is to summarize findings from recent RCTs assessing the efficacy of interventions designed to increase ACP uptake in cancer care.

Recent findings
The PubMed database was searched for studies published between 2021 and 2023. Ten RCTs were identified that evaluated a wide range of interventions aimed at encouraging or facilitating ACP communication among patients with advanced cancer, caregivers, and HCPs. Three RCTs developed ACP facilitation tools for patients and sometimes caregivers. Six RCTs involved integrating trained ACP facilitators into patient care, and one RCT used nudges to encourage oncologists trained in ACP discussions to initiate discussions with patients at highest risk of short-term mortality. Most of the reviewed interventions were based on previously tested intervention approaches or tools.

Summary
The key effects identified in this review are the facilitation of ACP discussions among patients, caregivers, and HCPs, and the documentation of patient preferences in the medical record. The direct involvement of facilitators in ACP document drafting and inclusion in patient files, as well as interventions prompting end-of-life discussions, contributed to this effect.
Low Expression of Vitamin D Receptor in Patients With Dry Eye Disease
Authors: Vieira Antonia , Meza Javiera , Garreton Rodolfo , Grau Arturo E. , Zoroquiain Pablo 
Published: May 2024

Purpose:
This study aimed to compare the expression of vitamin D receptor (VDR) on the ocular surface of patients with dry eye disease (DED) and controls without ophthalmological pathologies.

Methods:
Patients with DED without previous treatment were studied and compared with healthy subjects. Ocular Surface Disease Index assessement and ocular surface cytology were performed in all patients. The immunohistochemical expression of VDR was evaluated using fully automated immunohistochemistry. The evaluation involved multiplying the percentage of nuclear-labeled cells (0–100) by their intensity (0–3), resulting in a score ranging from 0 to 300 (VDR H-score). Squamous metaplasia was morphologically evaluated using liquid-phase cytology with Papanicolaou/periodic acid–Schiff staining using Nelson's grade (scale 0–3, higher grade to higher metaplastic change).

Results:
Eighteen patients with DED without previous treatment and 10 healthy subjects were studied. Squamous metaplasia was observed in 74% of patients with DED, in contrast to 0% in the control group. In patients with DED, there was a lower expression of VDR than in the control group (VDR H-score: 11.2 ± 13.9 vs. 80.9 ± 56; P = 0.0001). Furthermore, an inverse correlation was observed between Nelson grade and VDR H-score (P = 0.0001, rs = −0.71). No correlation was observed between Ocular Surface Disease Index and VDR H-score.

Conclusions:
This is the first study to evaluate the VDR in patients with DED. These patients presented with a lower expression of VDR than healthy subjects. No correlation was found with more severe symptoms. Patients with DED also had a higher frequency of squamous metaplasia.
Federally Qualified Health Centers’ Screening for Social Risk Factors and Health Outcomes
Authors: Davlyatov Ganisher , Choi Seongwon , Borkowski Nancy M. , Hearld Kristine R. , Aswani Monica 
Published: May 2024

Federally Qualified Health Centers (FQHCs) are ideally positioned to identify and address health-related social needs, but little is understood about the relationship between social risk factor (SRF) screening and health outcomes. We studied 1352 FQHCs from the 2019 Uniform Data System. Ordinary least squares regression was used to estimate the relationship between SRF screening and the percentage of patients with adequately controlled diabetes and hypertension. Results show 71% of the FQHCs in the sample collected SRFs. FQHCs’ screened for SRFs had higher percentages of patients with adequately controlled diabetes (69.5% vs 67.0%, P < .001) and hypertension (63.8% vs 59.4%, P < .001) relative to FQHCs not collecting SRFs.
Continuous renal surface cooling technique (CSCT) in robotic-assisted kidney transplantation: technique and outcomes from a high-volume center: a prospective cohort study
Authors: Zhang Haohan , Zeng Jun , Fan Yu , Ma Ming , Lin Tao , Song Turun 
Published: May 2024

Background:
Robot-assisted kidney transplantation (RAKT) surgery is an advanced minimally invasive technique, albeit with extended surgical and kidney ischemia time. To safeguard kidney function, the authors have devised a continuous surface cooling method (CSCT) for intraoperative kidney cooling.

Materials and methods:
Patients receiving RAKT were divided into CSCT group and conventional group. The CSCT is a custom-designed apparatus composed of a single-layer plastic bag, featuring an inflow and an outflow that create a closed circuit for the continuous flow of cooling saline. The conventional group utilized ice slush for kidney graft cooling (Vattikuti Urology Institute-Medanta Technique, VUIMT). Patients who underwent open renal transplantation during the same period were also included in the study. All patients were subject to a minimum 2-month follow-up. And 1:3 propensity score matching was used to minimize selection bias.

Results:
A total of 144 patients underwent CSCT, 47 underwent VUIMT, and 196 underwent open surgery were included in the study, while after matching, 129, 43, 129 patients were included in the three groups, respectively. The median follow-up time was 19 months. None of the patients experienced delayed graft function, patient mortality, or graft loss. After introducing the kidney into the abdominal cavity for 20 minutes, the surface temperature of the kidney in the CSCT group was notably lower compared to the VUIMT group (15.42±0.88 vs. 21.74±2.53°C, P=0.001). This temperature disparity became more pronounced at 65 min (19.74±1.61 vs. 29.82±1.63°C, P<0.001). At both 3 and 7 days post-transplantation, creatinine levels in the VUIMT group were significantly higher than those in the CSCT and open surgery groups (at 3 days, 244.13±45.61 vs. 182.51±55.47 in CSCT group, P<0.001, or vs. 182.77±61.32 in the open surgery group, P<0.001; at 7 days, 162.42±54.86 vs. 143.11±44.32 in the CSCT group, P<0.001, or vs. 135.23±45.27 in the open surgery group, P<0.001). No differences were observed in blood creatinine, estimated glomerular filtration rate, and perioperative complications between the CSCT and open surgery groups.

Conclusion:
The CSCT presents a significant advantage over the traditional VUIMT method in terms of kidney cooling and early postoperative kidney function preservation. Additional research is required to ascertain whether the CSCT can enhance the long-term prognosis of kidney transplant recipients.