bluuebunny/crossref_metadata_2025_split huggingface dataset:
MnO2 and roflumilast-loaded probiotic membrane vesicles mitigate experimental colitis by synergistically augmenting cAMP in macrophage
Authors: Song Chengjun , Wu Jiamin , Wu Jinhui , Wang Fangyu 
Published: May 2024

Abstract
Background
Ulcerative colitis (UC) is one chronic and relapsing inflammatory bowel disease. Macrophage has been reputed as one trigger for UC. Recently, phosphodiesterase 4 (PDE4) inhibitors, for instance roflumilast, have been regarded as one latent approach to modulating macrophage in UC treatment. Roflumilast can decelerate cyclic adenosine monophosphate (cAMP) degradation, which impedes TNF-α synthesis in macrophage. However, roflumilast is devoid of macrophage-target and consequently causes some unavoidable adverse reactions, which restrict the utilization in UC.

Results
Membrane vesicles (MVs) from probiotic Escherichia coli Nissle 1917 (EcN 1917) served as a drug delivery platform for targeting macrophage. As model drugs, roflumilast and MnO2 were encapsulated in MVs (Rof&MnO2@MVs). Roflumilast inhibited cAMP degradation via PDE4 deactivation and MnO2 boosted cAMP generation by activating adenylate cyclase (AC). Compared with roflumilast, co-delivery of roflumilast and MnO2 apparently produced more cAMP and less TNF-α in macrophage. Besides, Rof&MnO2@MVs could ameliorate colitis in mouse model and regulate gut microbe such as mitigating pathogenic Escherichia–Shigella and elevating probiotic Akkermansia.

Conclusions
A probiotic-based nanoparticle was prepared for precise codelivery of roflumilast and MnO2 into macrophage. This biomimetic nanoparticle could synergistically modulate cAMP in macrophage and ameliorate experimental colitis.

Graphical Abstract
Effects of flexor reflex stimulation on gait aspects in stroke patients: randomized clinical trial
Authors: Sehle Aida , Salzmann Christian , Liepert Joachim 
Published: May 2024

Abstract
Background
Gait deficits are very common after stroke and therefore an important aspect in poststroke rehabilitation. A currently little used method in gait rehabilitation after stroke is the activation of the flexor reflex (FR) by electrical stimulation of the sole of foot while walking. The aim of this study was to investigate the effect of FR stimulation on gait performance and gait parameters in participants with stroke within a single session of flexor reflex stimulation using Incedo™.

Methods
Twenty-five participants with subacute (n = 14) and chronic (n = 11) stroke were enrolled in the study. Motor functions were tested with a 10-m walk test (10mWT), a 2-min walk test (2minWT), and a gait analysis. These tests were performed with and without Incedo™ within a single session in randomized order.

Results
In the 10mWT, a significant difference was found between walking with Incedo™ (15.0 ± 8.5 s) versus without Incedo™ (17.0 ± 11.4 s, p = 0.01). Similarly, the 2minWT showed a significant improvement with Incedo™ use (90.0 ± 36.4 m) compared to without Incedo™ (86.3 ± 36.8 m, p = 0.03). These results indicate that while the improvements are statistically significant, they are modest and should be considered in the context of their clinical relevance. The gait parameters remained unchanged except for the step length. A subgroup analysis indicated that participants with subacute and chronic stroke responded similarly to the stimulation. There was a correlation between the degree of response to electrostimulation while walking and degree of improvement in 2minWT (r = 0.50, p = 0.01).

Conclusions
This study is the first to examine FR activation effects in chronic stroke patients and suggests that stimulation effects are independent of the time since stroke. A larger controlled clinical trial is warranted that addresses issues as the necessary number of therapeutical sessions and for how long stimulation-induced improvements outlast the treatment period.
Trial registration: The trial was retrospectively registered in German Clinical Trials Register. Clinical trial registration number: DRKS00021457. Date of registration: 29 June 2020.
Surgical approach on combined chronic patellar tendon and bicruciate knee ligament injury
Authors: Piedade Sérgio Rocha , Górios Carlos , Spiezia Filippo , Maffulli Nicola 
Published: May 2024

AbstractA combined injury of the patellar tendon and both the anterior and posterior cruciate ligaments is disabling. It directly affects knee kinematics and biomechanics, presenting a considerable surgical challenge. In this complex and uncommon injury, decision-making should take into account the surgeon’s experience and consider one- or two-stage surgery, tendon graft, graft fixation, and rehabilitation protocol. This manuscript discusses the surgical approach based on a comprehensive understanding of the patellar tendon and bicruciate biomechanics to guide which structures should be reconstructed first, especially when a two-stage procedure is chosen.
In vivo study of a novel 3D-printed motion-preservation artificial cervical corpectomy construct: short-term imaging and biocompatibility evaluations in a goat model
Authors: Wang Jian , Meng Bing , Wang Xinli , Lei Wei , Zhao Xiong 
Published: May 2024

Abstract
Background
Nonfusion technologies, such as motion-preservation devices, have begun a new era of treatment options in spine surgery. Motion-preservation approaches mainly include total disc replacement for anterior cervical discectomy and fusion. However, for multisegment fusion, such as anterior cervical corpectomy and fusion, the options are more limited. Therefore, we designed a novel 3D-printed motion-preservation artificial cervical corpectomy construct (ACCC) for multisegment fusion. The aim of this study was to explore the feasibility of ACCC in a goat model.

Methods
Goats were treated with anterior C3 corpectomy and ACCC implantation and randomly divided into two groups evaluated at 3 or 6 months. Radiography, 3D CT reconstruction and MRI evaluations were performed. Biocompatibility was evaluated using micro-CT and histology.

Results
Postoperatively, all goats were in good condition, with free neck movement. Implant positioning was optimal. The relationship between facet joints was stable. The range of motion of the C2-C4 segments during flexion–extension at 3 and 6 months postoperatively was 7.8° and 7.3°, respectively. The implants were wrapped by new bone tissue, which had grown into the porous structure. Cartilage tissue, ossification centres, new blood vessels, and bone mineralization were observed at the porous metal vertebrae-bone interface and in the metal pores.

Conclusions
The ACCC provided stabilization while preserving the motion of the functional spinal unit and promoting bone regeneration and vascularization. In this study, the ACCC was used for anterior cervical corpectomy and fusion (ACCF) in a goat model. We hope that this study will propel further research of motion-preservation devices.
Impact of frailty on mortality, hospitalization, cardiovascular events, and complications in patients with diabetes mellitus: a systematic review and meta-analysis
Authors: Miao Zhiying , Zhang Qiuyi , Yin Jijing , Li Lihua , Feng Yan 
Published: May 2024

Abstract
Background
Several studies have focused on the impact of frailty on the health outcomes of individuals with diabetes mellitus (DM). This meta-analysis aims to systematically synthesize the existing evidence on frailty and its association with mortality, hospitalizations, cardiovascular diseases, and diabetic complications in DM.

Methods
A comprehensive search in PubMed, Embase, and SCOPUS was carried out to identify relevant studies assessing the impact of frailty on mortality, hospitalizations, complications, and cardiovascular events in individuals with DM. The quality of the included studies was evaluated using the New Castle Ottawa Scale.

Results
From the 22 studies included, our meta-analysis revealed significant associations between frailty and adverse outcomes in individuals with DM. The pooled hazard ratios for mortality and frailty showed a substantial effect size of 1.84 (95% CI 1.46–2.31). Similarly, the odds ratio for hospitalization and frailty demonstrated a significant risk with an effect size of 1.63 (95% CI 1.50–1.78). In addition, frailty was associated with an increased risk of developing diabetic nephropathy (HR, 3.17; 95% CI 1.16–8.68) and diabetic retinopathy (HR, 1.94; 95% CI 0.80–4.71).

Conclusion
Our results show a consistent link between frailty and increased mortality, heightened hospitalization rates, and higher risks of cardiovascular disease, diabetic nephropathy, and diabetic retinopathy for patients with DM.
PROSPERO Registration Number: CRD42023485166
Another market segment: sport event tourism by disabled athletes
Authors: Yun Seokmin , Kim Kyungjin , Lee Sangyung , Kim Young Hoon 
Published: May 2024

AbstractSports and tourism are connected in various parts of economies, cultures, and nations. However, there has been a limited understanding of sports event tourism involving disabled athletes. This study explored the behavioral and socio-demographic implications of the disabled sports event tourism and investigated the motivational factors involved. An in-person survey was administered to 108 disabled athletes who attended the summer and winter Paralympics. A Structural Equation Model was used to determine the association between the factors of life satisfaction, emotional happiness, escapism, perceived value, and future intention, using the Monte Carlo parametric bootstrapping method to test significance of direct and indirect effects. Cronbach was acceptable because it exceeds 0.70 which satisfies the cut-off of confirmatory factor analysis. In addition, the individual values of average variance extracted (AVE), were greater than 0.50 (0.72) which meets the requirement and the convergent validity of all the constructs. The results showed that life satisfaction had a significant direct effect on future intentions. Emotional happiness had a significant direct effect on the perceived value of an event. Escapism had significant direct effects on perceived value and future intentions. Perceived value significantly influenced future intentions. The relationship between emotional happiness and future intention was fully mediated by perceived value. However, the relationship between escapism and future intention was only partially mediated by perceived value. The results of this study are valuable for developing future management and marketing policies for disabled athletes and tourists to advance the existing sports event tourism and disabled athlete’s behavior studies.
Effect of low versus high balance training complexity on balance performance in male adolescents
Authors: Muehlbauer Thomas , Eckardt Lucas , Höptner Lukas , Hill Mathew W. 
Published: May 2024

Abstract
Objective
The current study aimed to determine the effects of low (i.e., balance task only) versus high (i.e., balance task combined with an additional motor task like dribbling a basketball) balance training complexity (6 weeks of training consisting of 2 × 30 min balance exercises per week) on measures of static and dynamic balance in 44 healthy male adolescents (mean age: 13.3 ± 1.6 years).

Results
Irrespective of balance training complexity, significant medium- to large-sized pretest to posttest improvements were detected for static (i.e., One-Legged Stance test, stance time [s], 0.001 < p ≤ 0.008) and dynamic (i.e., 3-m Beam Walking Backward test, steps [n], 0.001 < p ≤ 0.002; Y-Balance-Test-Lower-Quarter, reach distance [cm], 0.001 < p ≤ 0.003) balance performance. Further, in all but one comparison (i.e., stance time with eyes opened on foam ground) no group × test interactions were found. These results imply that balance training is effective to improve static and dynamic measures of balance in healthy male adolescents, but the effectiveness seems unaffected by the applied level of balance training complexity.
Identifying novel clinical phenotypes of acute respiratory distress syndrome using trajectories of daily fluid balance: a secondary analysis of randomized controlled trials
Authors: Wu Fei , Shi Suqin , Wang Zixuan , Wang Yurong , Xia Le , Feng Qingling , Hang Xin , Zhu Min , Zhuang Jinqiang 
Published: May 2024

Abstract
Background
Previously identified phenotypes of acute respiratory distress syndrome (ARDS) could not reveal the dynamic change of phenotypes over time. We aimed to identify novel clinical phenotypes in ARDS using trajectories of fluid balance, to test whether phenotypes respond differently to different treatment, and to develop a simplified model for phenotype identification.

Methods
FACTT (conservative vs liberal fluid management) trial was classified as a development cohort, joint latent class mixed models (JLCMMs) were employed to identify trajectories of fluid balance. Heterogeneity of treatment effect (HTE) for fluid management strategy across phenotypes was investigated. We also constructed a parsimonious probabilistic model using baseline data to predict the fluid trajectories in the development cohort. The trajectory groups and the probabilistic model were externally validated in EDEN (initial trophic vs full enteral feeding) trial.

Results
Using JLCMM, we identified two trajectory groups in the development cohort: Class 1 (n = 758, 76.4% of the cohort) had an early positive fluid balance, but achieved negative fluid balance rapidly, and Class 2 (n = 234, 24.6% of the cohort) was characterized by persistent positive fluid balance. Compared to Class 1 patients, patients in Class 2 had significantly higher 60-day mortality (53.5% vs. 17.8%, p < 0.001), and fewer ventilator-free days (0 vs. 20, p < 0.001). A significant HTE between phenotypes and fluid management strategies was observed in the FACTT. An 8-variables model was derived for phenotype assignment.

Conclusions
We identified and validated two novel clinical trajectories for ARDS patients, with both prognostic and predictive enrichment. The trajectories of ARDS can be identified with simple classifier models.
Cerebellar liponeurocytoma: clinico-epidemiological, pathological, radiological, genetic, therapeutic and evolutionary characteristics—a review of the literature
Authors: Jribi Ahmed , Dhouib Fatma , Siala Wicem , Fourati Nejla , Daoud Jamel 
Published: May 2024

AbstractCerebellar liponeurocytoma is a rare benign tumor of the central nervous system affecting adults and mainly the posterior fossa. Its positive diagnosis remains difficult due to its rarity and the presence of several differential diagnoses including medulloblastoma. The oncogenetic mechanism, the therapeutic modalities and results are still currently under study. Very few cases have been published in the literature. The aim of this review is to report, through the available data, all its various clinico-epidemiological, pathological, radiological, genetic, therapeutic and evolutionary features. In fact, this tumor is associated with a slow-growing character, appears in young adulthood with slight female predominance and is often manifested by intracranial hypertension symptoms. It is pathologically characterized by a focal component of lipomatous differentiation and a low proliferation index. It is usually presented in imaging by a well-limited mass with signal attenuation for fatty tissue and heterogeneous contrast. No mutation has been identified yet. The gold standard treatment of this tumor is maximal complete resection. The evolutionary profile is marked by frequent local recurrence. Radiotherapy could be discussed in case of recurrence, incomplete surgery, inoperable cases and cases with high proliferation index, and there is to date no proof of benefit for systemic treatment. Due to the numerous similarities of this entity with medulloblastoma, it should be always evoked face to any suspicion of medulloblastoma in adults in order to avoid a wrong overtreatment.
Why choose BJPsych Bulletin?
Authors: Forrester Andrew 
Published: May 2024

SummaryBJPsych Bulletin was first established as the Bulletin of the Royal College of Psychiatrists in 1977. Since then, it has extended its influence within the field, and it is now the go-to journal for practical clinical considerations in psychiatry, and mental health more widely. It stands together with the wider family of RCPsych journals – BJPsych, BJPsych Advances, BJPsych Open and BJPsych International – and offers a number of distinct advantages for readers and authors. I commend it to you.
Better Living through Political Engineering
Authors: McCann Charles R. , Kapuria-Foreman Vibha 
Published: May 2024

Abstract
Much has been written about the philosophy of social control, particularly as it developed from the end of the nineteenth century to the early 1920s. Yet little if any appreciation has been given to the work of James MacKaye and Helen Sumner in promoting the program of political engineering and their efforts at establishing to this end an Institute of Political Engineering. This essay will examine the philosophy of James MacKaye and the creation of the institute that was to fulfill his mission, and it will highlight the important contribution of Helen Sumner in its creation.
Thoracic giant cell tumor after two total en bloc spondylectomies including one emergency surgery: A case report
Authors: Liang Hai-Feng , Xu Hao , Zhan Meng-Na , Xiao Jian , Li Juan , Fei Qin-Ming 
Published: May 2024

BACKGROUND
For patients with acute paraplegia caused by spinal giant cell tumor (GCT) who require emergency decompressive surgery, there is still a lack of relevant reports on surgical options. This study is the first to present the case of an acute paraplegic patient with a thoracic spinal GCT who underwent an emergency total en bloc spondylectomy (TES). Despite tumor recurrence, three-level TES was repeated after denosumab therapy.
CASE SUMMARY
A 27-year-old female patient who underwent single-level TES in an emergency presented with sudden severe back pain and acute paraplegia due to a thoracic spinal tumor. After emergency TES, the patient's spinal cord function recovered, and permanent paralysis was avoided. The postoperative histopathological examination revealed that the excised neoplasm was a rare GCT. Unfortunately, the tumor recurred 9 months after the first surgery. After 12 months of denosumab therapy, the tumor size was reduced, and tumor calcification. To prevent recurrent tumor progression and provide a possible cure, a three-level TES was performed again. The patient returned to an active lifestyle 1 month after the second surgery, and no recurrence of GCT was found at the last follow-up.
CONCLUSION
This patient with acute paraplegia underwent TES twice, including once in an emergency, and achieved good therapeutic results. TES in emergency surgery is feasible and safe when conditions permit; however, it may increase the risk of tumor recurrence.
Necroharms: Obscene and Grotesque Violence
Authors: Iliadou Evgenia 
Published: May 2024

The chapter explores the human consequences of the ‘necropolitical’ (Mbembe, 2003) border regime upon the lives which are made ‘unliveable’ (Butler, 2004). It focuses on the manifold abandonments (left-to-die practices) of border crossers, inside and beyond the refugee camp, in appalling conditions that not only are tantamount to torture or cruel, inhuman and degrading treatment, but also inflict, normalize and naturalize disposability, humiliation, social death and suffering. This chapter builds on Achille Mbembe’s (2003) work on necropolitics to explore the governance of migration through abandonment to social death. It also builds on existing academic literature on the politics of abandonment, the production of humiliation and degradation, racialized social death and disposability as a modus operandi of migration governance (Cacho, 2012; Davies et al, 2017; Mayblin et al, 2019; Gordon and Larsen, 2021).The chapter also engages with three bodies of literature: the social harm approach (Hillyard and Tombs, 2007), critical migration and border studies (De León, 2015; Squire, 2017) and social anthropology of violence (Scheper-Hughes and Bourgois, 2004). It provides insights into border crossers’ lived experiences of violence. Furthermore, the paper contributes to the growing academic literature on the politics of abandonment (Davies et al 2017; Gordon and Larsen, 2021; Mayblin et al, 2019), and disposability as a modus operandi of migration governance.
Assessing the impact of institutional mistrust on parental endorsement for COVID-19 vaccination among school communities in San Diego County, California
Authors: Le Tina , Flores Marlene , Omaleki Vinton , Hassani Ashkan , Vo Anh V. , Wijaya F. Carrissa , Garfein Richard S. , Fielding-Miller Rebecca 
Published: May 2024

Background
Institutional mistrust has weakened COVID-19 mitigation efforts. Assessing to what extent institutional mistrust impacts parental decision making is important in formulating structural efforts for improving future pandemic response. We hypothesized that institutional mistrust is associated with lower parental endorsement for COVID-19 vaccination.

Methods
We distributed an online survey among parents from schools in areas with high levels of social vulnerability relative to the rest of San Diego County. We defined vaccination endorsement as having a child aged 5 years or older who received at least one COVID-19 vaccine dose or being very likely to vaccinate their child aged 6 months—4 years when eligible. Institutional mistrust reflected the level of confidence in institutions using an aggregate score from 11 to 44. We built a multivariable logistic regression model with potential confounding variables.

Findings
Out of 290 parents in our sample, most were female (87.6%), reported their child as Hispanic/Latino (73.4%), and expressed vaccination endorsement (52.1%). For every one-point increase in mistrust score, there was an 8% reduction in the likelihood of participants endorsing vaccination for their child. Other statistically significant correlates that were positively associated with vaccination endorsement included parent vaccination status, child age, parent age, and Hispanic/Latino ethnicity.

Conclusion
Our study further demonstrates how institutional mistrust hinders public response during health emergencies. Our findings also highlight the importance of building confidence in institutions and its downstream effects on pandemic preparedness and public health. One way that institutions can improve their relationship with constituents is through building genuine partnerships with trusted community figures.