bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERBANDINGAN EFEKTIVITAS KONSUMSI BAYAM MERAH DAN BAYAM HIJAU TERHADAP KADAR HB IBU HAMIL TRIMESTER I DENGAN ANEMIA
Authors: Al Idrus Nurjana , Arlym Lisa Trina , Widowati Retno 
Published: May 2024

Latar Belakang : Anemia adalah suatu kondisi dimana jumlah sel darah merah atau konsentrasi hemoglobin (Hb) di dalam darah lebih rendah dari normal sedangkan penanggulangan anemia pada ibu hamil dengan memberikan 90 tablet Fe kepada ibu hamil selama periode kehamilan. Konsumsi sayur bayam merah dan sayur bayam hijau adalah salah satu alternatif yang dapat dilakukan untuk memenuhi kebutuhan tambahan zat besi Tujuan : Untuk mengetahui perbedaan efektivitas konsumsi sayur bayam merah dan sayur bayam hijau terhadap kadar Hb pada ibu hamil trimester I dengan anemia di TPMB Suraily Kabupaten Bogor Metode: Penelitian ini menggunakan quasy experiment dengan pendekatan two grou p pretest and posttest design. desain quasy experimen. Jumlah sampel 30 ibu hamil trimester I dengan anemia, yang terdiri dari 15 orang intervensi konsumsi sayur bayam merah dan intervensi konsumsi sayur bayam hijau terdiri 15 orang. Penelitian ini menggunakan lembar SOP untuk mengobservasi dan konsumsi sayur bayam merah dan sayur bayam hijau sebanyak 2 X 150 ml diberikan pagi dan soreh selama 14 hari. Data dan analisis dengan paired sample t-test untuk mengetahui perbedaan skor sebelum dan sesudah konsumsi. Independent t-test untuk mengetahui perbedaan antar kelompok uji. Hasil Penelitian : Terdapat perbedaan rata-rata sebelum dan sesudah konsumsi sayur bayam merh dengan nilai p-value 0,003 ≤ 0,05. Terdapat perbedaan rata-rata sebelum dan sesudah konsumsi sayur bayam hijau dengan nilai p-value 0,009 <0,05. Hasil uji independen tidak terdapat perbedaan konsumsi sayur bayam merah dengan sayur bayam hijau pada rata-rata kadar Hb. Kesimpulan : Mengkonsumsi sayur bayam merah dan sayur bayam hijau dapat meningkatkan kadar Hb ibu hamil trimester I dengan anemia.
ANALISIS PERILAKU HIDUP BERSIH DAN SEHAT DI MASJID
Authors: Utami Dwika Sari , Ismah Zata 
Published: May 2024

Latar belakang: Perilaku Hidup Bersih dan Sehat (PHBS) merupakan salah satu komponen penting dalam pembangunan kesehatan sehingga dapat terwujudnya derajat kesehatan secara optimal. Permasalahan sanitasi di tempat ibadah adalah air bersih, jamban, sampah, merokok dan jentik nyamuk. Tujuan: Untuk menganalisis perilaku hidup bersih dan sehat di lingkungan masjid. Metod: Penelitian dilakukan dengan metode deskriptif kuantitatif, populasi penelitian berupa masjid yang berada didaerah Kabupaten Simalungun dengan jumlah sampel sebanyak 32 masjid, teknik pengambilan sampel dilakukan dengan teknik simple random sampling, teknik pengumpulan data dilakukan dengan penyebaran kuesioner, dan analisis data dilakukan dengan analisis univariat. Hasil: Penerapan air bersih di lingkungan masjid yaitu seluruh masjid telah menerapkan aspek air bersih. (2) Penggunaan jamban di lingkungan masjid ditemukan sebagian besar atau sebanyak 25 masjid telah menerapkan aspek penggunaan jamban. Sementara sejumlah masjid atau 7 masjid belum menerapkan aspek tersebut. (3) Penerapan membuang sampah pada tempatnya di lingkungan masjid ditemukan hanya sebagian kecil atau sebanyak 8 dari jumlah masjid yang telah menerapkan aspek membuang sampah pada tempatnya. Selebihnya atau sebanyak 24 masjid belum menerapkan aspek tersebut. (4) Penerapan tidak merokok di tempat ibadah di lingkungan masjid ditemukan tidak ada satupun dari 32 masjid yang menerapkan aspek tidak merokok di tempat ibadah. (5) Penerapan aspek memberantas jentik di lingkungan masjid ditemukan hanya 4 masjid yang telah menerapkan, sebagian besar atau 28 masjid belum menerapkan aspek tersebut. Diskusi: Pengurus masjid agar dapat menjaga kebersihan masjid dan lebih intensif untuk meningkatkan kesadaran masyarakat mengenai kebersihan masjid.
GAMBARAN PENGETAHUAN IBU SETELAH DIBERIKAN EDUKASI TENTANG PMT BERBASIS KEARIFAN LOKAL
Authors: Anggraini Yuliza , Zalukhu Aze Renata Fenzelina 
Published: May 2024

Pendahuluan: Masalah gizi menjadi salah satu masalah terpenting yang harus ditangani pemerintah di dunia maupun di Indonesia untuk memperoleh generasi yang baik. Gizipada masa 5 tahun pertama kehidupan akan mempengaruhi pertumbuhan dan perkembangan balita di masa depan. Dampak yang dapat timbul akibat kekurangan gizi pada lima tahun pertama adalah perkembangan otak dan pertumbuhan. Pemberian Makanan Tambahan berbasis kearifan lokal adalah program pemerintah yang dapat dijadikan sebagai salah satu aternatif untuk mengatasi permasalah tersebut. Program ini bertujuan untuk memulihkan gizi balita dengan memberikan makanan dengan kandungan gizi yang cukup sehingga kebutuhan gizi balita dapat terpenuhi. Tujun Penelitian: Mengetahui gambaran pengetahuan ibu setelah diberikan edukasi tentang PMT berbasis kearifan lokal di Kenagarian Balingka. Metode Penelitian : kuantitatif dengan desain pendekatan deskritif. Populasi adalah ibu balita usia 12-24 bulan sebanyak 68 responden. Teknik pengambilan sampel menggunakan Simple Random Sampling dengan jumlah sampel sebanyak 33 orang. Hasil Penelitian : adanya peningkatan pengetahuan ibu setelah diberikan edukasi tentang PMT berbasis kearifan lokal sebesar 24.2%. Kesimpulan dan Saran : adanya peningkatan pengetahuan ibu setelah diberikan edukasi tentang PMT berbasis kearifan lokal sebesar 24.8%. Di sarankan setelah mendapatan edukasi tentang PMT berbasis kearifan lokal ini para ibu yang memiliki balita dapat mempraktikkannya setiap hari untuk pemenuhan gizi balita. Kata Kunci : Pengetahuan, PMT, kearifan lokal
Peran Guru Bimbingan Konseling Dalam Mengatasi Perilaku Bullying Verbal Siswa Di SMP Negeri 2 Rambatan
Authors: Koswara Fridameka , Irman Irman 
Published: May 2024

Bullying verbal merupakan masalah serius dalam dunia pendidikan yang dapat berdampak negative terhadap perkembangan social dan emosional siswa. Penelitian ini bertujuan untuk menyelidiki peran guru bimbingan konseling dalam mengatasi prilaku bullying verbal siswa di SMP Negeri 2 Rambatan. Penelitian ini menggunakan pendekatan kualitatif dengan metode studi kasus ganda dan melibatkan guru bimbingan konseling, siswa, dan staf sekolah. Sampel akan mencakup guru BK SMP Negeri 2 Rambatan yang memiliki pengalaman menangani kasus bullying verbal. Dan siswa yang pernah terlibat dalam kasus bullying verbal di sekolah tersebut akan menjadi bagian dari sampel. Pada penelitian ini dipilih dengan menggunakan teknik purposive sampling. Teknik purposive sampling adalah teknik penentuan sampel dengan pertimbangan tertentu. Purposive sampling juga disebut judgmental sampling, yaitu pengambilan sampel berdasarkan penilaian mengenai siapa-siapa saja yang pantas untuk dijadikan sampel. mengetahui secara lengkap. Temuan ini memberikan pandangan yang lebih dalam tentang upaya yang dapat dilakukan oleh guru bimbingan konseling untuk menciptakan lingkungan sekolah yang aman dan mendukung bagi semua siswa.
SOSIALISASI PENGEMASAN PRODUK, LABEL PRODUK DAN PEMBUATAN LAPORAN KEUANGAN SEDERHANA BAGI PELAKU UMKM DI DESA ADAT SANUR
Authors: Arianto Putu Intan , Yuniasih Ni Wayan , Netria Febriyanti Ni Luh Putu , Mayang Sari Dewi Ni Kadek , Dinda Dewi Ni Putu 
Published: May 2024

Desa Adat Sanur has the potential for natural resources in the form of abundant fish, but the utilization of these natural resources to increase selling value is still not optimal because the fish is sold raw without any processing. In addition, the potential of Desa Adat Sanur is also a strategic tourism object, with this potential certainly having an impact on Micro, Small and Medium Enterprises (MSMEs) around Desa Adat Sanur. However, there are still many business actors who still combine their business money with their personal money and have not kept financial records so that business profits are also not recorded. Based on these problems, socialization of Micro, Small and Medium Enterprises related to increasing selling value and financial recording is important even though it is simple. This village project activity has solutions related to the problems previously described. The method used in this village project is in the form of socialization and mentoring regarding fish processing into finished products in the form of crackers, product packaging, product labels and making simple financial reports for Micro, Small and Medium Enterprises (MSMEs). The results of this village project can provide an understanding of the importance of recording good financial statements and provide an explanation of how to increase the selling value of fish through the processing of raw fish products into finished products in the form of fish crackers.
Poor immune response to inactivated COVID-19 vaccine in patients with hypertension
Authors: Yang Lei , Zeng TingTing , Li Yang , Guo Qiao , Jiang DePeng 
Published: May 2024

PurposeThe safety and efficacy of vaccination in people with hypertension (HTN) is important. There are currently a few data on the immunogenicity and safety of inactivated SARS-CoV-2 vaccinations in hypertension patients.MethodsAfter receiving a two-dose immunization, 94 hypertension adult patients and 74 healthy controls (HCs) in this study, the evaluation included looking at antibodies (Abs) against receptor binding domain (RBD) IgG, SARS-CoV-2 neutralizing antibodies (NAbs), RBD-specific B cells, and memory B cells (MBCs).ResultsThere was no discernible difference in the overall adverse events (AEs) over the course of 7 or 30 days between HTN patients and HCs. HTN patients had lower frequencies of RBD-specific memory B cells and the seropositivity rates and titers of Abs compared with HCs (all, p &lt; 0.05). HTN patients with cardiovascular and cerebrovascular conditions (CCVD) have lower titers of CoV-2 NAb than in HCs. The titers of both Abs in HTN declined gradually over time.ConclusionInactivated COVID-19 vaccinations were safe in hypertension patients; however humoral immune was limited, especially merged CCVD and declined gradually over time.
Postoperative myopic shift and visual acuity rehabilitation in patients with bilateral congenital cataracts
Authors: Lin Duoru , Zhu Qiaolin , Zhang Shuyi , Zhou Fengqi , Zhao Lanqin , Wang Qiwei , Chen Wan , Chen Hui , Lin Xiaoshan , Feng Huanling , Zhong Qiuping , Chen Jingjing , Lin Zhuoling , Li Xiaoyan , Xiao Wei , Zhou Yue , Wang Jinghui , Li Jing , Chen Weirong 
Published: May 2024

BackgroundThis study aimed to explore the postoperative myopic shift and its relationship to visual acuity rehabilitation in patients with bilateral congenital cataracts (CCs).MethodsBilateral CC patients who underwent cataract extraction and primary intraocular lens implantations before 6 years old were included and divided into five groups according to surgical ages (&lt;2, 2–3, 3–4, 4–5, and 5–6 years). The postoperative myopic shift rates, spherical equivalents (SEs), and the best corrected visual acuity (BCVA) were measured and analyzed.ResultsA total of 1,137 refractive measurements from 234 patients were included, with a mean follow-up period of 34 months. The postoperative mean SEs at each follow-up in the five groups were linearly fitted with a mean R2 = 0.93 ± 0.03, which showed a downtrend of SE with age (linear regression). Among patients with a follow-up of 4 years, the mean postoperative myopic shift rate was 0.84, 0.81, 0.68, 0.24, and 0.28 diopters per year (D/y) in the five age groups (from young to old), respectively. The BCVA of those with a surgical age of &lt;2 years at the 4-year visit was 0.26 (LogMAR), and the mean postoperative myopic shift rate was 0.84 D/y. For patients with a surgical age of 2–6 years, a poorer BCVA at the 4-year visit was found in those with higher postoperative myopic shift rates (r = 0.974, p = 0.026, Pearson’s correlation test).ConclusionPerforming cataract surgery for patients before 2 years old and decreasing the postoperative myopic shift rates for those with a surgical age of 2–6 years may benefit visual acuity rehabilitation.
Blood brain barrier disruption and glutamatergic excitotoxicity in post-acute sequelae of SARS COV-2 infection cognitive impairment: potential biomarkers and a window into pathogenesis
Authors: Chaganti Joga , Poudel Govinda , Cysique Lucette Adeline , Dore Gregory J. , Kelleher Anthony , Matthews Gael , Darley David , Byrne Anthony , Jakabek David , Zhang Xin , Lewis Marrissa , Jha Nikhil , Brew Bruce James 
Published: May 2024

ObjectiveTo investigate the association between blood–brain barrier permeability, brain metabolites, microstructural integrity of the white matter, and cognitive impairment (CI) in post-acute sequelae of SARS-COV-2 infection (PASC).MethodsIn this multimodal longitudinal MRI study 14 PASC participants with CI and 10 healthy controls were enrolled. All completed investigations at 3 months following acute infection (3 months ± 2 weeks SD), and 10 PASC participants completed at 12 months ± 2.22 SD weeks. The assessments included a standard neurological assessment, a cognitive screen using the brief CogState battery and multi-modal MRI derived metrics from Dynamic contrast enhanced (DCE) perfusion Imaging, Diffusion Tensor Imaging (DTI), and single voxel proton Magnetic Resonance Spectroscopy. These measures were compared between patients and controls and correlated with cognitive scores.ResultsAt baseline, and relative to controls, PASC participants had higher K-Trans and Myo-inositol, and lower levels of Glutamate/Glutamine in the frontal white matter (FWM) (p &lt; 0.01) as well as in brain stem (p &lt; 0.05), and higher FA and lower MD in the FWM (p &lt; 0.05). In PASC participants, FA and MD decreased in the FWM at 12 months compared to baseline (p &lt; 0.05). K-Trans and metabolite concentrations did not change significantly over time. Neurocognitive scores did not correlation with the increased permeability (K trans).InterpretationPASC with CI is associated with BBB impairment, loss of WM integrity, and inflammation at 3 months which significantly but not uniformly improved at 12 months. The loss of WM integrity is possibly mediated by BBB impairment and associated glutamatergic excitotoxicity.
Phosphorylated neurofilament heavy chain in cerebrospinal fluid and plasma as a Nusinersen treatment response marker in childhood-onset SMA individuals from Serbia
Authors: Brkušanin Miloš , Kosać Ana , Branković-Srećković Vesna , Jovanović Kristina , Perić Stojan , Karanović Jelena , Matijašević Joković Suzana , Garai Nemanja , Pešović Jovan , Nikolić Dimitrije , Stević Zorica , Brajušković Goran , Milić-Rašić Vedrana , Savić-Pavićević Dušanka 
Published: May 2024

IntroductionBiomarkers capable of reflecting disease onset and short- and long-term therapeutic effects in individuals with spinal muscular atrophy (SMA) are still an unmet need and phosphorylated neurofilament heavy chain (pNF-H) holds significant promise.MethodsWe conducted a longitudinal prospective study to evaluate pNF-H levels in the cerebrospinal fluid (CSF) and plasma of 29 individuals with childhood-onset SMA treated with Nuinersen (SMA type 1: n = 6, 2: n = 17, 3: n = 6). pNF-H levels before and during treatment were compared with the levels of controls (n = 22), patients with Duchenne muscular dystrophy (n = 17), myotonic dystrophy type 1 (n = 11), untreated SMA individuals with chronic type 3 disease (n = 8), and children with presymptomatic SMA (n = 3).ResultsSMA type 1 showed the highest mean CSF pNF-H levels before treatment initiation. All Nusinersen-treated individuals (types 1, 2, and 3) showed significantly elevated mean baseline CSF pNF-H compared to controls, which inversely correlated with age at disease onset, age at first dose, disease duration and the initial CHOP INTEND result (SMA type 1 and 2). During 22 months of treatment, CSF pNF-H levels declined during loading doses, stabilizing at reduced levels from the initial maintenance dose in all individuals. Baseline plasma pNF-H levels in type 1 and 2 SMA were significantly increased compared to other cohorts and decreased notably in type 1 after 2 months of treatment and type 2 after 14 months. Conversely, SMA type 3, characterized by lower baseline pNF-H levels, did not show significant fluctuations in plasma pNF-H levels after 14 months of treatment.ConclusionOur findings suggest that CSF pNF-H levels in untreated SMA individuals are significantly higher than in controls and that monitoring of CSF pNF-H levels may serve as an indicator of rapid short-term treatment response in childhood-onset SMA individuals, irrespective of the subtype of the disease, while also suggesting its potential for assessing long-term suppression of neurodegeneration. Plasma pNF-H may serve as an appropriate outcome measure for disease progression and/or response to treatment in types 1 and 2 but not in type 3. Presymptomatic infants with SMA may show elevated pNF-H levels, confirming early neuronal degeneration.
Expanding the clinical spectrum of anti-DPPX encephalitis: a multicenter retrospective study
Authors: Gao Yining , Zhang Yizongheng , Chunyu Hangxing , Xu Yongfeng , Wang Ying , Liu Suzhi , Chang Jie , Tang Bo , Xu Congying , Lu Yi , Zhou Jian , Kong Xiangyong , Zhu Xiaoying , Chen Sheng , Zhou Qinming , Meng Huanyu 
Published: May 2024

ObjectiveAnti-dipeptidyl-peptidase-like protein-6 (DPPX) encephalitis is a rare autoimmune encephalitis, and clinical and experimental information regarding this disease is limited. We conducted this study to comprehensively describe the clinical characteristics, ancillary test results, neuroimaging results, and treatment response in a group of Chinese patients with anti-DPPX encephalitis for better understanding this disease.MethodsWe recruited 14 patients who tested positive for anti-DPPX antibodies in the serum and/or cerebrospinal fluid from 11 medical centers between March 2021 and June 2023. This retrospective study evaluated data on symptoms, autoantibody test, auxiliary examinations, treatments, and outcomes.ResultsThe average age at diagnosis was 45.93 ± 4.62 years (range: 11–72 years), and 9 of the 14 patients were males. The main symptoms included cognitive impairment (50.0%, 7/14), central nervous system hyperexcitability (42.9%, 6/14), gastrointestinal dysfunction (35.7%, 5/14), and psychiatric disorders (35.7%, 5/14). Notably, we discovered specific findings on 18F-fluorodeoxyglucose positron-emission tomography (PET)/magnetic resonance imaging in two patients. Co-existing autoantibodies were identified in two patients. Parainfection was identified in four patients. One patient had other autoimmune diseases, and one had tumor. Eleven patients received immunotherapy and most patients improved at discharge. Surprisingly, three male patients but no female patients relapsed during the 6 months of follow-up.ConclusionThe development and outcome of anti-DPPX encephalitis are variable. Male patients were predominant in our cohort. The most common symptoms were the classical triad of prodromal gastrointestinal dysfunction, cognitive and mental disorders, and central nervous system hyperexcitability. Infections, immune dysregulation, and tumors may be important etiologies. Long-term monitoring of disease development should be done in male patients. Overall, our results highlight novel clinical characteristics of anti-DPPX encephalitis.
The association between ondansetron use and mortality risk of traumatic brain injury patients: a population-based study
Authors: Wang Ruoran , Zhang Jing , Xu Jianguo , He Min 
Published: May 2024

Background:Traumatic brain injury (TBI) patients suffer high risks of mortality. Ondansetron has been verified to be effective in improving the prognosis of some kinds of critically ill patients. We design this study to explore whether ondansetron use is associated with lower risks of mortality among TBI patients.Methods:TBI patients from the Medical Information Mart for Intensive Care-III were collected. The usage of ondansetron, including intravenous injection and oral tablet, since admission to the Beth Israel Deaconess Medical Center between 2001 and 2012 was identified. Univariate and multivariate logistic regression were performed to analyze the relationship between the ondansetron use and mortality of TBI patients. Propensity score matching (PSM) was utilized to generate balanced cohorts of the non-ondansetron use group and ondansetron use group. Sub-group analysis was performed to verify the association between the ondansetron use and mortality of TBI patients in different TBI severity levels after PSM.Results:In TBI cohorts before PSM, the usage incidence of ondansetron was 37.2%. The 30-day mortality was significantly lower in the ondansetron group (p &lt; 0.001). The multivariate logistic regression showed that ondansetron was associated with the lower mortality of TBI patients (p = 0.008). In TBI cohorts after PSM, the 30-day mortality of the ondansetron group was lower than that of the non-ondansetron group, although without statistical significance (p = 0.079). Logistic regression indicated ondansetron use was significantly associated with the lower mortality of moderate-to-severe TBI (p &lt; 0.001) but not mild TBI (p = 0.051). In addition, Cox regression also presented that ondansetron use was significantly associated with the lower mortality of moderate-to-severe TBI (p &lt; 0.001) but not mild TBI (p = 0.052).Conclusion:Ondansetron usage is associated with a lower mortality risk of moderate-to-severe TBI but not mild TBI patients. Ondansetron may be a novel adjunctive therapeutic strategy to improve the prognosis of moderate-to-severe TBI patients.
Uptake and translocation of pharmaceutically active compounds by olive tree (Olea europaea L.) irrigated with treated municipal wastewater
Authors: Mininni Alba N. , Pietrafesa Angela , Calabritto Maria , Di Biase Roberto , Brunetti Gennaro , De Mastro Francesco , Murgolo Sapia , De Ceglie Cristina , Salerno Carlo , Dichio Bartolomeo 
Published: May 2024

IntroductionThe use of treated municipal wastewater (TWW) represents a relevant opportunity for irrigation of agricultural crops in semi-arid regions to counter the increasing water scarcity. Pharmaceutically active compounds (PhACs) are often detected in treated wastewater, posing a risk to humans and the environment. PhACs can accumulate in soils and translocate into different plant tissues, reaching, in some cases, edible organs and entering the food chain.MethodsThis study evaluated the uptake and translocation processes of 10 PhACs by olive trees irrigated with TWW, investigating their accumulation in different plant organs. The experiment was conducted in southern Italy, in 2-year-old plants irrigated with three different types of water: freshwater (FW), TWW spiked with 10 PhACs at a concentration of 200 µg L−1 (1× TWW), and at a triple dose (3× TWW), from July to October 2021. The concentration of PhACs in soil and plant organs was assessed, collecting samples of root, stem, shoot, leaf, fruit, and kernel at 0 (T0), 50 (T1), and 107 (T2) days of irrigation. PhACs extraction from soil and plant organs was carried out using the QuEChERS method, and their concentrations were determined by high-resolution mass spectrometry coupled with liquid chromatography.ResultsResults of uptake factors (UF) showed a different behavior between compounds according to their physicochemical properties, highlighting PhACs accumulation and translocation in different plant organs (also edible part) in 1× TWW and 3× TWW compared to FW. Two PhACs, carbamazepine and fluconazole, showed interactions with the soil–plant system, translocating also in the aerial part of the plant, with a translocation factor (TF) greater than 1, which indicates high root-to-leaf translocation.DiscussionFindings highlight that only few PhACs among the selected compounds can be uptaken by woody plants and accumulated in edible parts at low concentration. No effects of PhACs exposure on plant growth have been detected. Despite the attention to be paid to the few compounds that translocate into edible organs, these results are promising for adapting wastewater irrigation in crops. Increasing knowledge about PhACs behavior in woody plants can be important for developing optimized wastewater irrigation and soil management strategies to reduce PhACs accumulation and translocation in plants.