bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breast conserving surgery with intraoperative electron beam radiation therapy for low‐risk breast cancer: Five‐year follow‐up of 306 patients
Authors: de Jonge Charlotte , Schipper Robert‐Jan , Walstra Coco J. E. F. , Van Riet Yvonne E. , Verrijssen An‐Sofie E. , Voogd Adri C. , van der Sangen Maurice J. C. , Theuws Jacqueline , Degreef Ellen , Gielens Maaike P. M. , Bloemen Johanne G. , van den Berg Hetty A. , Nieuwenhuijzen Grard A. P. 
Published: May 2024

AbstractRecent studies have reported a higher than expected risk of ipsilateral breast tumor recurrence (IBTR) after breast conserving surgery (BCS) and a single dose of electron beam intra‐operative radiotherapy (IORT). This finding was the rationale to perform a retrospective single center cohort study evaluating the oncologic results of consecutive patients treated with BCS and IORT. Women were eligible if they had clinical low‐risk (N0, ≤2 cm unifocal, Bloom and Richardson grade 1–2), estrogen receptor‐positive and human‐epidermal‐growth‐factor‐receptor‐2‐negative breast cancer. Prior to BCS, pN0 status was determined by sentinel lymph node biopsy. Data on oncologic follow‐up were analyzed. Between 2012 and 2019, 306 consecutive patients were treated and analyzed, with a median age of 67 (50–86) years at diagnosis. Median follow‐up was 60 (8–120) months. Five‐year cumulative risk of IBTR was 13.4% (95% confidence interval [CI] 9.4–17.4). True in field recurrence was present in 3.9% of the patients. In 4.6% of the patients, the IBRT was classified as a local recurrence due to seeding of tumor cells in the cutis or subcutis most likely related to percutaneous biopsy. In 2.9% of the patients, the IBRT was a new outfield primary tumor. Three patients had a regional lymph node recurrence and two had distant metastases as first event. One breast cancer‐related death was observed. Estimated 5‐year overall survival was 89.8% (95% CI 86.0–93.6). In conclusion, although some of IBTR cases could have been prevented by adaptations in biopsy techniques and patient selection, BCS followed by IORT was associated with a substantial risk of IBTR.
Exploring the role of mean‐field potentials and short‐range wave function behavior in the adiabatic connection
Authors: Scemama Anthony , Savin Andreas 
Published: May 2024

AbstractIn this article, we explore the construction of Hamiltonians with long‐range interactions and their corrections using the short‐range behavior of the wave function. A key aspect of our investigation is the examination of the one‐particle potential, kept constant in our previous work, and the effects of its optimization on the adiabatic connection. Our methodology involves the use of a parameter‐dependent potential dependent on a single parameter to facilitate practical computations. We analyze the energy errors and densities in a two‐electron system (harmonium) under various conditions, employing different confinement potentials and interaction parameters. The study reveals that while the mean‐field potential improves the expectation value of the physical Hamiltonian, it does not necessarily improve the energy of the system within the bounds of chemical accuracy. We also delve into the impact of density variations in adiabatic connections, challenging the common assumption that a mean field improves results. Our findings indicate that as long as energy errors remain within chemical accuracy, the mean field does not significantly outperform a bare potential. This observation is attributed to the effectiveness of corrections based on the short‐range behavior of the wave function, a universal characteristic that diminishes the distinction between using a mean field or not.
Exposure–Response Analyses for Belzutifan to Inform Dosing Considerations and Labeling
Authors: Marathe Dhananjay D. , Jauslin Petra M. , Jan Kleijn Huub , De Miranda Silva Carolina , Chain Anne , Abraham Anson K. , Kauh Eunkyung A. , Liu Yanfang , Perini Rodolfo F. , Alwis Dinesh P. de , Jain Lokesh 
Published: May 2024

AbstractBelzutifan (Welireg, Merck & Co., Inc., Rahway, NJ, USA) is an oral, potent hypoxia‐inducible factor‐2α inhibitor, recently approved in the United States for the treatment of von Hippel–Lindau (VHL) disease‐associated renal cell carcinoma (RCC) and other VHL disease‐associated neoplasms. Safety and efficacy were investigated in two clinical studies: a Phase 1 dose escalation/expansion study in solid tumors and RCC and a Phase 2 study in VHL‐RCC. A population pharmacokinetic model was used to estimate belzutifan exposures to facilitate exposure–response (E‐R) analyses for efficacy and safety endpoints. Relationships between exposure and efficacy (overall response rate, disease control rate, progression‐free survival, best overall tumor size response, and other endpoints), safety outcomes (Grade ≥3 anemia, Grade ≥3 hypoxia, and time to first dose reduction/dose interruption), and pharmacodynamic biomarkers (erythropoietin [EPO] and hemoglobin [Hgb]) were evaluated using various regression techniques and time‐to‐event analyses. Efficacy E‐R was generally flat with non‐significant positive trends with exposure. The safety E‐R analyses demonstrated a lack of relationship for Grade ≥3 hypoxia and a positive relationship for Grade ≥3 anemia, with incidences also significantly dependent on baseline Hgb. Exposure‐dependent reductions in EPO and Hgb were observed. Based on the cumulative benefit–risk assessment in VHL disease‐associated neoplasms using E‐R, no a priori dose adjustment is recommended for any subpopulation. These analyses supported the benefit–risk profile of belzutifan 120 mg once daily dosing in patients with VHL‐RCC for labeling and the overall development program.
Global subterranean estuaries modify groundwater nutrient loading to the ocean
Authors: Wilson Stephanie J. , Moody Amy , McKenzie Tristan , Cardenas M. Bayani , Luijendijk Elco , Sawyer Audrey H. , Wilson Alicia , Michael Holly A. , Xu Bochao , Knee Karen L. , Cho Hyung‐Mi , Weinstein Yishai , Paytan Adina , Moosdorf Nils , Chen Chen‐Tung Aurthur , Beck Melanie , Lopez Cody , Murgulet Dorina , Kim Guebuem , Charette Mathew A. , Waska Hannelore , Ibánhez J. Severino P. , Chaillou Gwénaëlle , Oehler Till , Onodera Shin‐ichi , Saito Mitsuyo , Rodellas Valenti , Dimova Natasha , Montiel Daniel , Dulai Henrietta , Richardson Christina , Du Jinzhou , Petermann Eric , Chen Xiaogang , Davis Kay L. , Lamontagne Sebastien , Sugimoto Ryo , Wang Guizhi , Li Hailong , Torres Américo I. , Demir Cansu , Bristol Emily , Connolly Craig T. , McClelland James W. , Silva Brenno J. , Tait Douglas , Kumar BSK , Viswanadham R. , Sarma VVSS , Silva‐Filho Emmanoel , Shiller Alan , Lecher Alanna , Tamborski Joseph , Bokuniewicz Henry , Rocha Carlos , Reckhardt Anja , Böttcher Michael Ernst , Jiang Shan , Stieglitz Thomas , Gbewezoun Houégnon Géraud Vinel , Charbonnier Céline , Anschutz Pierre , Hernández‐Terrones Laura M. , Babu Suresh , Szymczycha Beata , Sadat‐Noori Mahmood , Niencheski Felipe , Null Kimberly , Tobias Craig , Song Bongkeun , Anderson Iris C. , Santos Isaac R. 
Published: May 2024

AbstractTerrestrial groundwater travels through subterranean estuaries before reaching the sea. Groundwater‐derived nutrients drive coastal water quality, primary production, and eutrophication. We determined how dissolved inorganic nitrogen (DIN), dissolved inorganic phosphorus (DIP), and dissolved organic nitrogen (DON) are transformed within subterranean estuaries and estimated submarine groundwater discharge (SGD) nutrient loads compiling > 10,000 groundwater samples from 216 sites worldwide. Nutrients exhibited complex, nonconservative behavior in subterranean estuaries. Fresh groundwater DIN and DIP are usually produced, and DON is consumed during transport. Median total SGD (saline and fresh) fluxes globally were 5.4, 2.6, and 0.18 Tmol yr−1 for DIN, DON, and DIP, respectively. Despite large natural variability, total SGD fluxes likely exceed global riverine nutrient export. Fresh SGD is a small source of new nutrients, but saline SGD is an important source of mostly recycled nutrients. Nutrients exported via SGD via subterranean estuaries are critical to coastal biogeochemistry and a significant nutrient source to the oceans.
Significance of the order of pair‐wise comparisons in Analytic Hierarchy Process: an experimental study
Authors: Andriichuk Oleh , Kadenko Sergii , Tsyganok Vitaliy 
Published: May 2024

AbstractThe article describes an approach, ensuring higher credibility of expert estimation results, based on specific order of pair‐wise comparisons. The order of pair‐wise comparisons is, in its turn, based on the distance between estimated objects in the ranking. According to the suggested approach (and some human psychophysiological features), the most ordinally distant objects should be compared before ordinally closer ones. In order to empirically confirm this assumption, a special experiment involving real experts has been conducted. The results of the experiment indicate that if objects are presented to the expert for comparison in the suggested order, then in the majority of cases relative weights of objects, obtained using eigenvector method, most adequately reflect this expert's priorities. Moreover, pair‐wise comparison matrices constructed using the suggested comparison order tend to be slightly more consistent. The suggested approach to re‐ordering of pair‐wise comparisons can be applied as part of the AHP algorithm in weakly structured subject domains, influenced by multiple intangible criteria. It also provides conceptual basis for reduction of the number of pair‐wise comparisons, required to obtain credible results, in AHP without loss or distortion of expert data. It can also be used for modification of combinatorial pair‐wise comparison aggregation method, based on spanning tree enumeration. And, finally, it will improve the overall multi‐criteria decision‐making process in diverse subject domains, characterized by high uncertainty levels.
Dietary Flavonoid Quercetin Supplement Promotes Antiviral Innate Responses Against Vesicular Stomatitis Virus Infection by Reshaping the Bacteriome and Host Metabolome in Mice
Authors: Li Tingting , Zhu Jinfeng , Yu Qifeng , Zhu Yinrui , Wu Chao , Zheng Xing , Chen Nannan , Pei Pei , Yang Kai , Wang Kai , Hu Lin 
Published: May 2024

ScopeActive ingredients in functional foods exhibit broad‐spectrum antiviral activity. The objective of this study is to investigate the protective effect of quercetin derived from bee propolis, a natural product with antiviral activity and modulating effects on the gut microbiota, against vesicular stomatitis virus (VSV) infection.Methods and resultsThrough a cellular‐based study, this study demonstrates that quercetin can modulate the activity of interferon‐regulating factor 3 (IRF3). In vivo, it shows that quercetin protects mice from VSV infection by enhancing interferon production and inhibiting the production of proinflammatory cytokines. The study conducts 16S rRNA‐based gut microbiota and nontargets metabolomics analyses to elucidate the mechanisms underlying quercetin‐mediated bidirectional communication between the gut microbiome and host metabolome during viral infection. Quercetin not only ameliorates VSV‐induced dysbiosis of the intestinal flora but also alters serum metabolites related to lipid metabolism. Cross‐correlations between the gut bacteriome and the serum metabolome indicate that quercetin can modulate phosphatidylcholine (16:0/0:0) and 5‐acetylamino‐6‐formylamino‐3‐methyluracil to prevent VSV infection.ConclusionThis study systematically elucidates the anti‐VSV mechanism of quercetin through gut bacteriome and host metabolome assays, offering new insights into VSV treatment and revealing the mechanisms behind a novel disease management strategy using dietary flavonoid supplements.
Solventless Synthesis of Zinc Sulphide Nanoparticles from Zinc Bis(diethyldithiocarbamate) as a Single Source Precursor
Authors: Saah Selina Ama , Sakyi Patrick Opare , Boadi Nathaniel Owusu , Tieku Franklyn Addai , Boampong Ampem Kwabena 
Published: May 2024

AbstractThis study explores the synthesis of nanoparticles through the thermal decomposition of single‐source precursors, a method gaining popularity due to its low cost, minimal environmental toxicity, rapidity, scalability, and the ability to form nanoparticles with few defects. Zinc ethyl carbamate was synthesized and characterized using 1H NMR and infrared spectroscopy. Its purity was confirmed through microelemental analysis and melting point determination. The melting point of the complex was determined to be 165 °C. The thermogravimetric analyses indicated a one‐step decomposition of zinc ethyl carbamate with a decomposition onset of of 200 °C, yielding a stable ZnS residue. Further thermal decomposition led to the formation of wurtzite phase ZnS nanoparticles, as evidenced by XRD. SEM micrographs displayed mixed spherical, and cubic unevenly sized, polydispersed nanoparticles, while EDX revealed approximately a 1 : 1 Zn to S ratio. Estimated band gap from the Tauc's plot gave 3.93 eV and 3.42 eV for the nanoparticles synthesized at 300 and 400 °C respectively. The wide difference in the band gaps may be as a result of the larger particles observed at 400 °C and the deformations in the sample as observed in the SEM.
Surface Oxygen Defect Engineering of A2B2O7 Pyrochlore Semiconductors Boosts the Electrocatalytic Reduction of CO2‐to‐HCOOH
Authors: Zhao Jiwu , Wang Jiashun , Xue Lan , Wang Ying , Wen Na , Huang Haowei , Zhang Zizhong , Ding Zhengxin , Yuan Rusheng , Roeffaers Maarten B.J. , Fu Xianzhi , Lu Xu , Long Jinlin 
Published: May 2024

AbstractThe electrocatalytic conversion of inert CO2 to value‐added chemical fuels powered by renewable energy is one of the benchmark approaches to address excessive carbon emissions and achieve carbon‐neutral energy restructuring. However, the adsorption/activation of supersymmetric CO2 is facing insurmountable challenges that constrain its industrial‐scale applications. Here, this theory‐guided study confronts these challenges by leveraging the synergies of bimetallic sites and defect engineering, where pyrochlore‐type semiconductor A2B2O7 is employed as research platform and the conversion of CO2‐to‐HCOOH as the model reaction. Specifically, defect engineering intensified greatly the chemisorption‐induced CO2 polarization via the bimetallic coordination, thermodynamically beneficial to the HCOOH production via the *HCO2 intermediate. The optimal V‐BSO‐430 electrocatalyst with abundant surface oxygen vacancies achieved a superior HCOOH yield of 116.7 mmol h−1 cm−2 at −1.2 VRHE, rivalling the incumbent similar reaction systems. Furthermore, the unique catalytic unit featured with a Bi1‐Sn‐Bi2 triangular structure, which is reconstructed by defect engineering, and altered the pathway of CO2 adsorption and activation to allow the preferential affinity of the suspended O atom in *HCO2 to H. As a result, V‐BSO‐430 gave an impressive FEHCOOH of 93% at −1.0 VRHE. This study held promises for inspiring the exploration of bimetallic materials from the massive semiconductor database.
Outcomes of surgical revascularization for pediatric moyamoya disease and syndrome
Authors: Boulter Jason H. , Szuflita Nicholas S. , Keating Robert F. , Magge Suresh N. 
Published: May 2024

Abstract
Purpose
Moyamoya disease and syndrome represent rare entities characterized by progressive stenosis and/or occlusion of the intracranial blood vessels. We present our series of patients with moyamoya disease and syndrome stratified by underlying disease and analyze differences in presentation and outcome following surgical revascularization.

Methods
This was an Institutional Review Board (IRB) approved, retrospective review of all patients surgically revascularized by the senior author (SNM) while at Children’s National Hospital in Washington, DC. Demographic data, presenting symptoms and severity, surgical details, and functional and radiographic outcomes were obtained and analyzed for differences among the underlying cohorts of moyamoya disease and syndrome as well as by unilateral or bilateral disease and index or non-index surgeries.

Results
Twenty-two patients were identified with the following underlying diseases: six with idiopathic moyamoya disease, six with sickle cell anemia, five with trisomy 21, and five with neurofibromatosis type 1. Thirty hemispheres were revascularized with a significantly reduced rate of stroke from 3.19 strokes/year (SD = 3.10) to 0.13 strokes/year (SD = 0.25), p = 0.03. When analyzed by underlying cause of moyamoya syndrome, patients with neurofibromatosis type 1 were found to be significantly less likely than the other subtypes of moyamoya syndrome to have had either a clinical stroke (0.0% neurofibromatosis type 1 vs. 100.0% sickle cell, 60.0% trisomy 21, or 83.3% moyamoya disease, p < 0.01) or radiographic stroke (0.0% neurofibromatosis type 1 vs. 100.0% sickle cell, 60.0% trisomy 21, or 83.3% moyamoya disease, p < 0.01) at time of presentation. Patients with moyamoya syndrome associated with sickle cell disease were more likely to present with clinical and radiographic strokes. Additionally, patients with bilateral disease demonstrated no difference in final functional outcome compared to patients with unilateral disease (mRS 0.73 (SD = 1.33) vs. 1.29 (SD = 1.60), p = 0.63).

Conclusion
Indirect surgical revascularization decreases stroke risk for pediatric patients with different forms of moyamoya disease and moyamoya syndrome. Additionally, these data suggest that sickle cell anemia-associated moyamoya syndrome may represent a more aggressive variant, while neurofibromatosis type 1 may represent a more benign variant.
The emerging role and mechanism of HMGA2 in breast cancer
Authors: Ma Qing , Ye Sisi , Liu Hong , Zhao Yu , Zhang Wei 
Published: May 2024

AbstractHigh mobility group AT-hook 2 (HMGA2) is a member of the non-histone chromosomal high mobility group (HMG) protein family, which participate in embryonic development and other biological processes. HMGA2 overexpression is associated with breast cancer (BC) cell growth, proliferation, metastasis, and drug resistance. Furthermore, HMGA2 expression is positively associated with poor prognosis of patients with BC, and inhibiting HMGA2 signaling can stimulate BC cell progression and metastasis. In this review, we focus on HMGA2 expression changes in BC tissues and multiple BC cell lines. Wnt/β-catenin, STAT3, CNN6, and TRAIL-R2 proteins are upstream mediators of HMGA2 that can induce BC invasion and metastasis. Moreover, microRNAs (miRNAs) can suppress BC cell growth, invasion, and metastasis by inhibiting HMGA2 expression. Furthermore, long noncoding RNAs (LncRNAs) and circular RNAs (CircRNAs) mainly regulate HMGA2 mRNA and protein expression levels by sponging miRNAs, thereby promoting BC development. Additionally, certain small molecule inhibitors can suppress BC drug resistance by reducing HMGA2 expression. Finally, we summarize findings demonstrating that HMGA2 siRNA and HMGA2 siRNA-loaded nanoliposomes can suppress BC progression and metastasis.
Das Angehörigengespräch im Rahmen der postmortalen Organspende aus der Sicht von Ärzt:innen und Pflegenden: Ergebnisse einer qualitativen Interviewstudie aus Österreich
Authors: Posch Christiane , Flatscher-Thöni Magdalena 
Published: May 2024

ZusammenfassungDie enge Widerspruchslösung in Österreich erlaubt eine postmortale Organspende bei fehlendem Widerspruch zu Lebzeiten, da von einer mutmaßlichen Zustimmung ausgegangen wird. Liegt kein Eintrag im Widerspruchsregister vor, wird die Familie zum mutmaßlichen Willen der verstorbenen Person befragt.Um die praktische Umsetzung der Widerspruchslösung in Österreich zu beschreiben, sollen relevante Aspekte der Angehörigengespräche und die Rolle der Familie im Entscheidungsprozess zur postmortalen Organspende identifiziert werden.Es wurden insgesamt zehn leitfadengestützte Expert:inneninterviews mit Ärzt:innen und Pflegepersonen an einer österreichischen Krankenanstalt durchgeführt, die mithilfe der qualitativen Inhaltsanalyse nach Mayring unter Anwendung von MAXQDA ausgewertet wurden.Herausforderungen beim Ermitteln des mutmaßlichen Patient:innenwillens im Angehörigengespräch können aufgrund von unterschiedlichen Kulturen/Religionen, Uneinigkeit und Entscheidungsunfähigkeit in der Familie aufgrund von Trauer und der Schwierigkeit der Angehörigen, das Hirntodkonzept zu begreifen, entstehen. Daher ist eine gute Vorbereitung, ausreichend Zeit, interdisziplinäre Zusammenarbeit, das Schaffen von Vertrauen und professionelle Gesprächsführung sowie das Eingehen auf Fragen und Bedürfnisse von Angehörigen durch Ärzt:innen und Pflegepersonen in einem geeigneten Setting notwendig. Die Kommunikation mit Angehörigen bezüglich einer postmortalen Organspende ist sowohl für das Gesundheitspersonal als auch die Familie belastend.Anhand der Ergebnisse wird die Anwendung des Kommunikationsleitfadens der Gesundheit Österreich mit Erweiterung um die Information zur Gesetzeslage sowie regelmäßige Kommunikationsschulungen des Gesundheitspersonals empfohlen. Zudem wird eine flächendeckende Information der Bevölkerung zur Förderung der intrafamiliären Diskussion gefordert.
APPEAL: a toolkit for attracting people who inject drugs with hepatitis C to healthcare systems
Authors: Baptista-Leite Ricardo , Lopes Henrique , Franco Diogo , Clemens Timo , Brand Helmut 
Published: May 2024

Abstract
Aim
The “APPEAL” toolkit was developed to address the challenges in diagnosing people who inject drugs (PWID) with hepatitis C (HCV) and engaging them with healthcare systems. It introduces an ecosystemic approach based on health and well-being literacy across awareness, prevention and diagnosis dimensions of the hepatitis C’s care cascade (CC) for PWID.

Subject and methods
The framework incorporated a scoping review and thematic analysis of 54 studies, alongside contributions from 57 hepatitis C key opinion leaders across seven countries. The toolkit is structured around five main axes: problems, solutions, outputs, outcomes and feedback process, employing a holistic perspective that considers economic, legal and social contexts. Eighteen policy prescriptions (PP) are proposed and supported by selective references to ensure relevance and applicability.

Results
The APPEAL toolkit facilitates a strategic workflow for policymakers, health authorities and patient advocacy organizations, guiding them through action flowcharts to evaluate and enhance their interventions within the hepatitis C’s CC for PWID. Notably, its implementation demonstrated potential in identifying and attracting PWID to hepatitis C treatment pathways, contributing to increased diagnostics, education on risk behaviours and raising overall disease awareness. The toolkit’s intelligent cycle system supports accountability, enabling continuous data-driven improvement and innovation in addressing hepatitis C.

Conclusion
The APPEAL toolkit was developed to attract PWID living with HCV to healthcare systems in a proactive manner. By managing information and fostering education on HCV, it aims to amplify awareness, prevention and diagnosis. The toolkit’s design and functionality underscore the importance of continuous quality improvement and the potential for its use in internal or external quality audits of healthcare services related to hepatitis C.