bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entre angoisse et créativité : les compagnons imaginaires
Authors: de Bérail Brune , Missonnier Sylvain 
Published: November 2010

La revue de la littérature sur le thème des compagnons imaginaires permet de dégager un continuum du phénomène, allant de l’objet transitionnel « virtuel » de l’enfant qui joue à la manifestation d’une structuration pathologique – le compagnon imaginaire se confond avec le persécuteur, investi sur le mode hallucinatoire. L’objet de cette recherche est de tenter de dégager des axes de lecture pouvant enrichir l’interprétation de ce phénomène pluriel. Les conceptions associées au motif du double par Rank, Freud et Nathan sont ici convoquées. Issu du refoulement originaire, le motif du double psychique serait une représentation des limites du moi. Cette hypothèse prolonge les travaux de S. Freud et A. Freud sur la valeur défensive du compagnon imaginaire, ceux de Nagera, Benson and Pryor insistant sur son rôle de renforcement narcissique et ceux d’Amado et Costes situant ce symptôme dans une pathologie de l’aire transitionnelle.
Méthodes techniques et outils
Authors: Diallo Alpha , Lebigre Loïc , Dupin Corinne , Ertzscheid Olivier 
Published: November 2010

Résumé Trois contributions figurent dans la rubrique « Méthodes, techniques et outils » de ce numéro : un point sur la normalisation en cours du management de l’intelligence stratégique, ; un compte rendu d’une journée d’étude consacrée aux nouveaux horizons professionnels ouverts par la gestion de contenu ; et une chronique sur la manière dont le Web peut être instrumentalisé
droit de l'information
Authors: Taillefer Marion 
Published: November 2010

Résumé Deux articles figurent dans la rubrique « Droit de l’information » de ce numéro : un compte rendu d’une journée d’étude sur le thème « Innovations Web 2.0 et données publiques » et une chronique sur les excès possibles de la protection des auteurs par le droit de la propriété intellectuelle.
Development of a decision support model for screening attention-deficit hyperactivity disorder with actigraph-based measurements of classroom activity
Authors: Kam H.J. , Shin Y.M. , Cho S.M. , Kim S.Y. , Kim K.W. , Park R.W. 
Published: November 2010

Summary
Objective: Questionnaire-based ADHD screening tests may not always be objective or accurate, owing to both subjectivity and prejudice. Despite attempts to develop objective measures to characterize ADHD, no widely applicable index currently exists. The principal aim of this study was to develop a decision support model for ADHD screening by monitoring children’s school activities using a 3-axial actigraph.
Methods: Actigraphs were placed on the non-dominant wrists of 153 children for 3 hours, while they were at school. Children who scored high on the questionnaires were clinically examined by child psychiatrists, who then confirmed ADHD. Mean, variance, and ratios of low-level (0.5-1.0G) and high-level (1.6-3.2G) activity were extracted as activity features from 142 children (10 ADHD, 132 non-ADHD). Two decision-tree models were constructed using the C5.0 algorithm: [A] from whole hours (class + playtime) and [B] during classes. Accuracy, sensitivity, and specificity were evaluated. PPV, NPV, likelihood ratio, and AUC were also calculated for evaluation.
Results: [Model A] One child without ADHD was misclassified, resulting in an accuracy score of 99.30%. Sensitivity and NPV were 1.0000. Specificity and PPV were 0.992 and 0.803-0.909, respectively. [Model B] Two children without ADHD were misclassified, resulting in an accuracy score of 98.59%. Specificity and PPV were scored at 0.985 and 0.671-0.832, respectively.
Conclusion: The selected features were consistent with the findings of previous studies. Objective screening of latent patients with ADHD can be accomplished with a simple watch-like sensor, which is worn for just a few hours while the child attends school. The model proposed herein can be applied to a great many children without heavy cost in time and manpower cost, and would generate valuable results from a public health perspective.
The development of the Social Bullying Involvement Scales
Authors: Fitzpatrick Sally , Bussey Kay 
Published: November 2010

AbstractThis study reports findings of a newly developed measure of social bullying based on Underwood's [2003] framework of social aggression. The Social Bullying Involvement Scales (SBIS) consist of four scales measuring the extent to which children experience social victimization, engage in social bullying, witness social bullying, and intervene in social bullying. The sample consisted of 636 participants (311 females and 325 males, age range 11–16 years; 71% White). Confirmatory factor analysis supported a revised version of Underwood's framework for each of the four participant role scales. Internal consistencies for each scale ranged from .93 to .97. Results revealed that social victimization was related to an increase in anxiety, depressive, and externalizing behaviors. Social bullying was associated with an increase in general externalizing behaviors only. Social witnessing was moderately correlated with depression scores. Intervening in social bullying was not linked with psychological maladjustment or externalizing behaviors. The SBIS provides a comprehensive measure of social victimization, social bullying, social witnessing, and social intervening. Aggr. Behav. 37:177–192, 2011. © 2010 Wiley‐Liss, Inc.
Sex differences in the consequences of early‐life exposure to epidemiological stress—A life‐history approach
Authors: Störmer Charlotte 
Published: November 2010

AbstractObjectives:Exposure to infectious disease in early life has been suggested to have a negative effect on later‐life survival, possibly through the induction of inflammatory responses. Although a life‐course perspective emphasizes the importance of both survival and reproduction for individual fitness, to date, no studies have investigated whether early‐life exposure to infectious disease has an impact on reproduction as it has been suggested for later survival.Methods:To address this question, I have used family reconstitution data from a historical (18th and 19th century) human population in theKrummhörn(Germany) comparing survival and reproduction between an exposed and a nonexposed group. The exposed group comprised those exposed to a high‐infectious disease load during prenatal and early postnatal development.Results:The results show a marked sex difference in the impact of early‐life exposure to infectious disease. Exposed females show no effect on their life expectancy but significantly reduced fertility (number of children). For exposed males, however, the effect on survival is opponent over time: mortality is increased during childhood but decreased in late adulthood. Above that, exposed males reproduce earlier and have a smaller proportion of surviving children.Conclusions:This study does not support former studies indicating a negative association between early‐life disease load and later survival. I argue that due to differences in male and female life strategies, males in general are more vulnerable especially early in life. Hence, adverse environmental conditions may have a stronger effect on male survivability and reproductive performance. Am. J. Hum. Biol., 2010. © 2010 Wiley‐Liss, Inc.
NOMPC, a member of the TRP channel family, localizes to the tubular body and distal cilium of Drosophila campaniform and chordotonal receptor cells
Authors: Liang Xin , Madrid Johnson , Saleh Henri S. , Howard Jonathon 
Published: November 2010

AbstractMechanoreception underlies the senses of touch, hearing and balance. An early event in mechanoreception is the opening of ion channels in response to mechanical force impinging on the cell. Here, we report antibody localization of NOMPC, a member of the transient receptor potential (TRP) ion channel family, to the tubular body of campaniform receptors in the halteres and to the distal regions of the cilia of chordotonal neurons in Johnston's organ, the sound‐sensing organ of flies. Because NOMPC has been shown to be associated with the mechanotransduction process, our studies suggest that the transduction apparatus in both types of sensory cells is located in regions where a specialized microtubule‐based cytoskeleton is in close proximity to an overlying cuticular structure. This localization suggests a transmission route of the mechanical stimulus to the cell. Furthermore, the commonality of NOMPC locations in the two structurally different receptor types suggests a conserved transduction apparatus involving both the intracellular cytoskeleton and the extracellular matrix. © 2010 Wiley‐Liss, Inc.
Impact of insurance type on survivor‐focused and general preventive health care utilization in adult survivors of childhood cancer
Authors: Casillas Jacqueline , Castellino Sharon M. , Hudson Melissa M. , Mertens Ann C. , Lima Isac S. F. , Liu Qi , Zeltzer Lonnie K. , Yasui Yutaka , Robison Leslie L. , Oeffinger Kevin C. 
Published: November 2010

AbstractBACKGROUND:Lack of health insurance is a key barrier to accessing care for chronic conditions and cancer screening. The influence of insurance type (private, public, none) on survivor‐focused and general preventive health care in adult survivors of childhood cancer was examined.METHODS:The Childhood Cancer Survivor Study is a retrospective cohort study of childhood cancer survivors diagnosed between 1970 and 1986. Among 8425 adult survivors, the relative risk (RR) and 95% confidence interval (CI) of receiving survivor‐focused and general preventive health care were estimated for uninsured (n = 1390) and publicly insured (n = 640), compared with for the privately insured (n = 6395)RESULTS:Uninsured survivors were less likely than those privately insured to report a cancer‐related visit (adjusted RR, 0.83; 95% CI, 0.75‐0.91) or a cancer center visit (adjusted RR, 0.83; 95% CI, 0.71‐0.98). Uninsured survivors had lower levels of utilization in all measures of care in comparison with privately insured. In contrast, publicly insured survivors were more likely to report a cancer‐related visit (adjusted RR, 1.22; 95% CI, 1.11‐1.35) or a cancer center visit (adjusted RR, 1.41; 95% CI, 1.18‐1.70) than were privately insured survivors. Although publicly insured survivors had similar utilization of general health examinations, they were less likely to report a Papanicolaou test or a dental examinationsCONCLUSIONS:Among this large, socioeconomically diverse cohort, publicly insured survivors utilize survivor‐focused health care at rates at least as high as survivors with private insurance. Uninsured survivors have lower utilization of both survivor‐focused and general preventive health care. Cancer 2011. © 2010 American Cancer Society.
Late age at first full term birth is strongly associated with lobular breast cancer
Authors: Newcomb Polly A. , Trentham‐Dietz Amy , Hampton John M. , Egan Kathleen M. , Titus‐Ernstoff Linda , Warren Andersen Shaneda , Greenberg E. Robert , Willett Walter C. 
Published: November 2010

AbstractBACKGROUND:Late age at first full‐term birth and nulliparity are known to increase breast cancer risk. The frequency of these risk factors has increased in recent decades.METHODS:The purpose of this population‐based case‐control study was to examine associations between parity, age at first birth (AFB), and specific histological subtypes of breast cancer. Women with breast cancer were identified from cancer registries in Wisconsin, Massachusetts, and New Hampshire. Control subjects were randomly selected from population lists. Interviews collected information on reproductive histories and other risk factors. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of ductal, lobular, and mixed ductal‐lobular breast cancer diagnosis in association with AFB and nulliparity.RESULTS:AFB ≥30 years was associated with a 2.4‐fold increase in risk of lobular breast cancer compared with AFB <20 years (OR, 2.4; 95% CI, 1.9‐2.9). The association was less pronounced for ductal breast cancer (OR, 1.3; 95% CI, 1.2‐1.4). Nulliparity was associated with increased risk for all breast cancer subtypes, compared with women with AFB <20 years, but the association was stronger for lobular (OR, 1.7; 95% CI, 1.3‐2.2) than for ductal (OR, 1.2; 95% CI, 1.1‐1.3) subtypes (P = .004). The adverse effects of later AFB was stronger with obesity (P = .03) in lobular, but not ductal, breast cancer.CONCLUSIONS:Stronger associations observed for late AFB and nulliparity suggest that these factors preferentially stimulate growth of lobular breast carcinomas. Recent temporal changes in reproductive patterns and rates of obesity may impact the histological presentation of breast cancer. Cancer 2011. © 2010 American Cancer Society.
Multifactorial central nervous system recurrence susceptibility in patients with HER2‐positive breast cancer
Authors: Musolino Antonino , Ciccolallo Laura , Panebianco Michele , Fontana Elisa , Zanoni Daniele , Bozzetti Cecilia , Michiara Maria , Silini Enrico Maria , Ardizzoni Andrea 
Published: November 2010

AbstractBACKGROUND:A series of retrospective studies have reported that patients with human epidermal growth factor receptor 2(HER2)‐positive breast cancer are at a greater risk of central nervous system (CNS) metastases. Trastuzumab, which does not cross the blood‐brain barrier, has been associated with this increased risk.METHODS:The authors evaluated incidence, survival, and risk factors for CNS metastases in the incident breast cancer population systematically collected by the Parma Province Cancer Registry over the 4‐year period between 2004 and 2007.RESULTS:A total of 1458 patients with a diagnosis of stage I to III invasive breast cancer were analyzed for study purposes. At a median follow‐up of 4.1 years, CNS events were observed in 1.3% and 5% of HER2‐negative patients and HER2‐positive patients, respectively (P< .0001). The administration of trastuzumab either as adjuvant therapy or for metastatic disease was associated with a significantly increased risk of CNS involvement at first disease recurrence and after first extracranial recurrence, respectively. According to multivariate analysis, HER2‐positive status and trastuzumab treatment, high Ki‐67 index, and hormone receptor negativity remained independent risk factors for the development of CNS metastasis.CONCLUSIONS:To the authors' knowledge, this is the first population‐based cancer registry study analyzing factors associated with CNS recurrence in a general population of newly diagnosed breast cancer patients with known HER2 status. The data from the current study provide evidence that patients with HER2‐positive breast cancer have a significantly higher incidence of CNS metastasis after treatment with trastuzumab. Improvements in systemic control and overall survival associated with trastuzumab‐based therapy may lead to an “unmasking” of CNS disease recurrence that would otherwise remain clinically silent before a patient's death. Cancer 2011. © 2010 American Cancer Society.
Real‐Time Probing of Ion Pairing Dynamics with 2DIR Spectroscopy
Authors: Park Kwang‐Hee , Choi Seung Ryul , Choi Jun‐Ho , Park Sungnam , Cho Minhaeng 
Published: November 2010

AbstractChemical exchange two‐dimensional infrared (2DIR) spectroscopy is applied to investigate ion pairing dynamics occurring on picosecond timescales. SeCN− ion is used as a vibrational probe. The SeCN− ion dissolved in N,N‐dimethyl formamide (DMF) has a sufficiently long vibrational lifetime and can form a contact ion pair with Li+ ion in DMF. The CN stretch frequency of the contact ion pair is significantly blue‐shifted from that of free SeCN− so the free SeCN− ion can be spectrally distinct from the contact ion pair in DMF. Therefore, we were able to directly monitor the ion pairing dynamics of Li+ and SeCN− in real time by using ultrafast 2DIR spectroscopy. As a result, we have determined the dissociation time constant of the LiSeCN contact ion pair to be 420±40 ps.
Interactive segmentation of clustered cells via geodesic commute distance and constrained density weighted Nyström method
Authors: Du Cheng‐Jin , Marcello Marco , Spiller David G. , White Michael R. H. , Bretschneider Till 
Published: November 2010

AbstractAn interactive method is proposed for complex cell segmentation, in particular of clustered cells. This article has two main contributions: First, we explore a hybrid combination of the random walk and the geodesic graph based methods for image segmentation and propose the novel concept of geodesic commute distance to classify pixels. The computation of geodesic commute distance requires an eigenvector decomposition of the weighted Laplacian matrix of a graph constructed from the image to be segmented. Second, by incorporating pairwise constraints from seeds into the algorithm, we present a novel method for eigenvector decomposition, namely a constrained density weighted Nyström method. Both visual and quantitative comparison with other semiautomatic algorithms including Voronoi‐based segmentation, grow cut, graph cuts, random walk, and geodesic method are given to evaluate the performance of the proposed method, which is a powerful tool for quantitative analysis of clustered cell images in live cell imaging. © 2010 International Society for Advancement of Cytometry
Evaluation of basophil activation in mastocytosis with Hymenoptera venom anaphylaxis
Authors: González‐de‐Olano D. , Álvarez‐Twose I. , Morgado J. M. , López M. I. Esteban , Castro A. Vega , Díaz de Durana M. D. Alonso , Sánchez‐Muñoz L. , Matito A. , de la Hoz Caballer B. , Sanz M. L. , Orfao A. , Escribano L. 
Published: November 2010

AbstractBackground:Basophil activation tests (BATs) have been demonstrated to be useful in detecting IgE‐mediated sensitization by measuring basophil activation surface markers (CD63 and CD203c). Hymenoptera venom is one of the best known mediators‐release trigger in patients with systemic mastocytosis (SM). The aim of this study was to investigate the use of BATs as an additional diagnostic tool in patients with mastocytosis suffering from hymenoptera venom anaphylaxis (HVA).Methods:A total of 22 patients with history of HVA and SM, together with a group of 11 patients with HVA in whom SM was ruled out after a complete bone marrow study, were analyzed.Results:Among 11 SM patients who had specific serum IgE (sIgE) against hymenoptera venom and an evaluable BAT, a positive BAT was found in nine. Additionally, a positive BAT was detected in three of seven patients who had no sIgE. These three patients had low levels of total IgE compared with control population (mean of 20 vs. 78 IU/mL); one had discontinued immunotherapy after 5 years, when sIgE levels had turned negative, and, in the other two patients, BAT identified the culprit insect.Conclusions:BAT is a useful complementary diagnostic tool to sIgE in mastocytosis patients with HVA, and it may contribute to predict or confirm these nearly fatal reactions, especially before discontinuing venom immunotherapy in patients who are negative for skin tests or sIgE or display low total IgE levels; in such cases, it also provides evidence on the culprit insect prompting HVA. © 2010 International Clinical Cytometry Society
Widely expressed Af17 is likely not required for embryogenesis, hematopoiesis, and animal survival
Authors: Zhang Zhijing , Huang Le , Reisenauer Mary Rose , Wu Hongyu , Chen Lihe , Zhang Yujin , Xia Yang , Zhang Wenzheng 
Published: November 2010

AbstractAs a putative transcription factor, Af17 may play a role in multiple signaling pathways. However, the Af17 expression profile during development and in adult tissues remains largely uncharacterized. The importance of Af17 function in embryogenesis, hematopoiesis, and animal survival has never been addressed before. Here we report the generation of the first Af17 mutant mouse model and characterization of the Af17 temporal and spatial expression profile in various embryonic stages and adult tissues by X‐gal staining, in situ hybridization, and RT‐PCR. Af17 expression is detected in specific cell populations in all stages and in multiple tissues examined. In situ hybridization yielded a consistent Af17 expression pattern by X‐gal staining. Homozygous mutant mice are viable, fertile, normal in size, and do not display any gross physical, behavioral, or hematopoietic abnormalities. Thus, our studies describe the generation of the first Af17 mutant mouse model, provide the first developmental profile of Af17 expression, and reveal that Af17 may be dispensable for normal embryogenesis, hematopoiesis, and animal survival. genesis 48:693–706, 2010. © 2010 Wiley‐Liss, Inc.
Late side effects of radioactive iodine on salivary gland function in patients with thyroid cancer
Authors: Almeida Juliana Pereira , Sanabria Álvaro Enrique , Lima Eduardo Nóbrega Pereira , Kowalski Luiz Paulo 
Published: November 2010

AbstractBackground.The purpose of this study was to assess the late side effects of radioiodine therapy (RIT) on salivary gland function. One hundred eighty two patients were evaluated.Methods.Assessment of salivary gland function was performed with salivary gland scintigraphy (SGS), sialometry, and subjective open questions to determine common side effects of RIT on salivary gland function.Results.RIT had a strong association with decreased elimination counts by SGS. Patient age was the only variable associated with sialometry; age and the use of xerostomic drugs were strongly associated with decreased mean values of salivary flow. Dysphagia was strongly associated with RIT. Using multiple logistic regression analysis, age was determined to be an important factor associated with salivary gland dysfunction, and RIT was associated with impairment of saliva excretion.Conclusion.These results show that patients subjected to RIT have more difficulty in draining saliva, mainly from the parotid glands, which is associated with clinical dysphagia in this subset of patients. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Clinical significance of TRAIL and TRAIL receptors in patients with head and neck cancer
Authors: Yoldas Burcak , Ozer Cem , Ozen Ozlem , Canpolat Tuba , Dogan Isilay , Griffith Thomas S. , Sanlioglu Salih , Ozluoglu Levent N. 
Published: November 2010

AbstractBackground.Tumor necrosis factor (TNF)‐related apoptosis‐inducing ligand (TRAIL) is a death ligand currently under clinical trials for cancer. The molecular profile of TRAIL and TRAIL receptors has not yet been mapped for patients with laryngeal squamous cell carcinoma (SCC) or patients with oral cavity squamous cell carcinoma (OCSCC).Methods.Paraffin‐embedded tissues from 60 patients with laryngeal SCC and 14 patients with OCSCC were retrospectively analyzed using immunohistochemistry.Results.An increase in decoy‐R1 (DcR1) but a decrease in decoy‐R2 (DcR2) expression were observed in patients with laryngeal SCC and in patients with OCSCC compared with control individuals with benign lesions. Clinical and pathologic grading revealed distinctive TRAIL and TRAIL receptor profiles in patients with squamous cell carcinoma of the head and neck (SCCHN).Conclusions.TRAIL and a TRAIL receptor expression profile might be useful to follow‐up disease progression by virtue of its connection with clinical staging and pathologic grading in patients with laryngeal SCC. © 2010 Wiley Periodicals, Inc. Head Neck, 2010