bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination of lipoic acid, Trolox methyl ether and tocopherols in human plasma by liquid‐chromatography and ion‐trap tandem mass spectrometry
Authors: Montero Olimpio , Ramírez María , Sánchez‐Guijo Alberto , González Constancio 
Published: January 2012

ABSTRACTA method for the simultaneous determination of lipoic acid and/or Trolox methyl ether, along with α‐, γ‐ and δ‐tocopherol was developed using liquid chromatography–tandem mass spectrometry with negative electrospray ionization (HPLC‐ESI‐MS/MS) in an ion‐trap mass spectrometer. Detection and quantification were accomplished by a multiple reaction monitoring method, using specific transitions from precursor ion to product ion for each analyte. Chromatographic separation was achieved in a 12 min run using a C18‐bonded phase and methanol–aqueous ammonium acetate elution gradient. Linear correlations of the chromatographic peak area (r.u. × s−1) to the injected amount (ng) gave the slope values (r.u. × s−1 × ng−1) 2.34 × 104 for α‐tocopherol, 5.05 × 104 for γ‐tocopherol, 1.27 × 105 for δ‐tocopherol, 8.86 × 105 for lipoic acid and 1.23 × 105 for Trolox methyl ether. The lower limit of quantification ranged between 0.02 and 1.22 ng for Trolox methyl ether and lipoic acid. MS3 experiments of γ‐ and δ‐tocopherol suggest ion‐radical reactions and dependence of the tocopherol fragmentation pattern on the phenolic ring methylation degree. The method is shown to be applicable to measurement of these metabolites in human serum after extraction. Copyright © 2012 John Wiley & Sons, Ltd.
Large‐Scale Honeycomb Microstructures Constructed by Platinum–Acetylide Gelators through Supramolecular Self‐Assembly
Authors: Xu Xing‐Dong , Zhang Jing , Chen Li‐Jun , Zhao Xiao‐Li , Wang De‐Xian , Yang Hai‐Bo 
Published: January 2012

AbstractA series of new platinum–acetylide complexes 4 a–4 c and 6 a–6 c were synthesized and characterized. The gelation properties of these compounds were investigated by the “stable‐to‐inversion‐of‐test‐tube” method. Unlike compounds 4 a–4 c, amides 6 b and 6 c can gelate a variety of nonpolar alkyl solvents; this result indicates that the hydrogen bonds between amide groups play an important role in the formation of metallic organogels. Interestingly, compared to the typical morphologies of known organogels or metallic organogels, compounds 6 b and 6 c exhibited highly ordered honeycomb patterns on a large‐scale (determined by SEM analysis). To investigate the driving forces for the self‐assembly process, concentration‐dependent 1H NMR spectroscopy and a competitive experiment between hydrogen bonds were used to confirm that intermolecular hydrogen bonding play an essential role during the formation of supramolecular aggregates.
Socioeconomic status and the risk of colorectal cancer
Authors: Doubeni Chyke A. , Laiyemo Adeyinka O. , Major Jacqueline M. , Schootman Mario , Lian Min , Park Yikyung , Graubard Barry I. , Hollenbeck Albert R. , Sinha Rashmi 
Published: January 2012

AbstractBACKGROUND:No previous prospective US study has examined whether the incidence of colorectal cancer (CRC) is disproportionately high in low socioeconomic status (SES) populations of both men and women. This study examined the relationship between both individual and area‐level SES and CRC incidence, overall and by tumor location.METHODS:Data were obtained from the ongoing prospective National Institutes of Health‐AARP Diet and Health Study of persons (50‐71 years old) who resided in 6 US states and 2 metropolitan areas at baseline in 1995‐1996. Incident CRCs were ascertained from tumor registries through December 2006. SES was measured by self‐reported education and census‐tract socioeconomic deprivation. Baseline and follow‐up questionnaires collected detailed information on individual‐level CRC risk factors including family history and health behaviors.RESULTS:Among 506,488 participants analyzed, 7676 were diagnosed with primary invasive colorectal adenocarcinomas: 46.6% in the right colon, 26.7% in the left colon, and 25.9% in the rectum. The overall incidence of CRC was significantly higher among people who had low educational level or lived in low‐SES neighborhoods, relative to respective highest‐SES groups, even after accounting for other risk factors. These associations were stronger in the rectum than in left or right colon. In the right colon, there were no significant SES differences by either SES measure after accounting for covariates.CONCLUSIONS:SES, assessed by either individual‐level education or neighborhood measures, was associated with risk of CRC even after accounting for other risk factors. The relationship between SES and CRC was strongest in the rectum and weakest in the right colon. Cancer 2012;3636–3644. © 2012 American Cancer Society.
Assessment of the pathologic inclusion criteria from contemporary adjuvant clinical trials for predicting disease progression after nephrectomy for renal cell carcinoma
Authors: Kim Simon P. , Crispen Paul L. , Thompson R. Houston , Weight Christopher J. , Boorjian Stephen A. , Costello Brian A. , Lohse Christine M. , Leibovich Bradley C. 
Published: January 2012

AbstractBACKGROUND:The objective of this study was to evaluate the accuracy of the pathologic inclusion criteria from all contemporary adjuvant trials in predicting disease progression (DP) for renal cell carcinoma (RCC).METHODS:A retrospective review was conducted on 1363 patients treated surgically for M0 RCC at the Mayo Clinic (Rochester, MN), from 1990 to 2001. Clinicopathologic features were reviewed to determine eligibility for the following trials: ARISER, ASSURE, EVEREST, PROTECT, SORCE, and S‐TRAC. DP was defined as local recurrence or distant metastasis after surgery. The ability of each trial's inclusion criteria to accurately predict DP was evaluated by the c (concordance) index.RESULTS:From the Mayo Clinic cohort, we determined that 41%, 45%, 45%, 33%, 47%, and 23% of the patients would have been eligible for the ARISER, ASSURE, EVEREST, PROTECT, SORCE, and S‐TRAC clinical trials, respectively. Overall, 23% of all patients experienced DP (n = 317). Among eligible patients, 53%, 44%, 44%, 57%, 43%, and 59% developed DP during follow‐up and 10%, 6%, 6%, 13%, 6%, and 18% went onto DP while not being eligible for the ARISER, ASSURE, EVEREST, PROTECT, SORCE, and S‐TRAC trials, respectively. The c index of each trial to accurately predict DP from the pathologic inclusion criteria of ARISER, ASSURE, EVEREST, PROTECT, SORCE, and S‐TRAC were 0.751, 0.751, 0.751, 0.742, 0.745, and 0.691, respectively.CONCLUSIONS:Although the pathologic inclusion criteria of contemporary adjuvant trials have notable differences, all 6 adjuvant trials demonstrated high predictive accuracy of DP. Overall, 43% to 59% of patients included for the adjuvant trials would develop DP, whereas 6% to 18% of patients excluded from the trials would develop DP during follow‐up. Cancer 2012. © 2012 American Cancer Society.
Delusion Proneness and Emotion Appraisal in Individuals with High Psychosis Vulnerability
Authors: Szily Erika , Kéri Szabolcs 
Published: January 2012

Evidence suggests that emotional processes play an important role in the development of delusions. The aim of the present study was to investigate emotion appraisal in individuals with high and low psychosis proneness. We compared 30 individuals who experienced a transient psychotic episode followed by a complete remission with 30 healthy control volunteers. The participants received the Peters et al. Delusion Inventory (PDI) and the Scherer's Emotion Appraisal Questionnaire. We also assessed the IQ and the severity of depressive and anxiety symptoms. Results revealed that individuals with high psychosis proneness displayed increased PDI scores and more pronounced anxiety compared with individuals with low psychosis proneness. There was a specific pattern of emotion appraisal in individuals with high psychosis proneness. In the case of fear, they achieved higher scores for external causality and immorality, and lower scores for coping ability and self‐esteem compared with individuals with low proneness. The PDI scores were weakly related to external causality (r = 0.41) and self‐esteem (r = −0.37). In the case of sadness and joy, no emotion appraisal differences were found between participants with low and high proneness. These results suggest that individuals who had a history of psychotic breakdown and therefore exhibit high psychosis proneness display an altered appraisal of fear, emphasizing external circumstances, feeling less power to cope and experience low self‐esteem. Copyright © 2011 John Wiley & Sons, Ltd.Key Practitioner Message

Patients remitted from a transient psychotic episode still exhibit milder forms of delusion proneness.
Emotion appraisal for fear is related to delusion proneness.
Clinicians should pay a special attention to self‐esteem and attribution biases in psychosis‐prone individuals.
Design of reliable fiber‐based distribution networks modeled by multi‐objective combinatorial optimization
Authors: Haidine Abdelfatteh 
Published: January 2012

SUMMARYIn this work, we investigate the planning of hybrid fiber/very high bit rate digital subscriber line (HFV) access networks. This HFV variant is considered as an alternative to passive optical access network. It consists of implementing optical fibers in the access network part from the central office to the street cabinets, whereas the very high bit rate digital subscriber line technology is used in the last meter part, from street cabinets to subscribers. Firstly, we discuss the different tasks of this planning problem. We model this planning problem as a multi‐objective optimization problem, where different conflicting objectives have to be optimized at the same time. We consider network costs and network reliability. This problem is solved by two different approaches: the classical single‐objective optimization (SOO) and the multi‐objective optimization (MOO), which is a recent optimization approach that is gaining an increasing interest in practical optimization problems. MOO solves the problem by searching for different optimal trade‐offs between the optimization objectives. The performances of SOO and MOO are analyzed and compared with each other using three network instances. Copyright © 2012 John Wiley & Sons, Ltd.
Zebrafish cadherin‐11 participates in retinal differentiation and retinotectal axon projection during visual system development
Authors: Clendenon Sherry G. , Sarmah Swapnalee , Shah Bijal , Liu Qin , Marrs James A. 
Published: January 2012

AbstractBackground: Cadherins orchestrate tissue morphogenesis by controlling cell adhesion, migration and differentiation. Various cadherin family members are expressed in the retina and other neural tissues during embryogenesis, regulating development of these tissues. Cadherin‐11 (Cdh11) is expressed in mesenchymal, bone, epithelial, neural and other tissues, and this cadherin was shown to control cell migration and differentiation in neural crest, tumor and bone cells. Our previous studies characterized Cdh11 expression and function in zebrafish. Results: Here, we report effects of Cdh11 loss‐of‐function on visual system development using morpholino oligonucleotide knockdown methods. Cdh11 is expressed in the retina and lens during retinal differentiation. Cdh11 loss‐of‐function produced defects in retinal differentiation and lens development. Cdh11 loss‐of‐function also reduced retinotectal axon projection and organization, consistent with known Cdh11 function in cell migration. Conclusion: Cdh11 expression in the developing visual system and Cdh11 loss‐of‐function phenotype illustrates the critical role for differential cadherin activity in visual system differentiation and organization. Developmental Dynamics 241:442–454, 2012. © 2012 Wiley Periodicals, Inc.
Characterization and Stability Study of Immobilized PQQ‐Dependent Aldose Dehydrogenase Bioanodes
Authors: Tuurala Saara , Lau Carolin , Atanassov Plamen , Smolander Maria , Minteer Shelley D. 
Published: January 2012

AbstractIn this paper, glucose oxidizing bioanodes employing immobilized PQQ‐dependent aldose dehydrogenase were prepared and characterized. The enzyme was immobilized on carbon paper in two different polymeric systems: tetrabutylammonium bromide (TBAB) modified Nafion and butanal modified chitosan. Characterization of the bioanodes included electron microscopy, electrochemical evaluation, as well as stability and leaching studies. Results indicate that the operational degradation was the same but the long term storage stability is better in the case of modified Nafion. The performance of the modified Nafion immobilized bioanodes stayed at 70 % of the initial value after 60 days of storing at 4 °C and 25 °C. Compared to TBAB modified Nafion immobilized bioanodes, butanal modified chitosan immobilized bioanodes showed 50 % activity after eight weeks storage at 4°C and one week storage at 25 °C. However, the electrochemical properties of modified chitosan were better.
Uncoupling of RAD51 focus formation and cell survival after replication fork stalling in RAD51D null CHO cells
Authors: Urbin Salustra S. , Elvers Ingegerd , Hinz John M. , Helleday Thomas , Thompson Larry H. 
Published: January 2012

AbstractIn vertebrate cells, the five RAD51 paralogs (XRCC2/3 and RAD51B/C/D) enhance the efficiency of homologous recombination repair (HRR). Stalling and breakage of DNA replication forks is a common event, especially in the large genomes of higher eukaryotes. When cells are exposed to agents that arrest DNA replication, such as hydroxyurea or aphidicolin, fork breakage can lead to chromosomal aberrations and cell killing. We assessed the contribution of the HRR protein RAD51D in resistance to killing by replication‐associated DSBs. In response to hydroxyurea, the isogenic rad51d null CHO mutant fails to show any indication of HRR initiation, as assessed by induction RAD51 foci, as expected. Surprisingly, these cells have normal resistance to killing by replication inhibition from either hydroxyurea or aphidicolin, but show the expected sensitivity to camptothecin, which also generates replication‐dependent DSBs. In contrast, we confirm that the V79 xrcc2 mutant does show increased sensitivity to hydroxyurea under some conditions, which was correlated to its attenuated RAD51 focus response. In response to the PARP1 inhibitor KU58684, rad51d cells, like other HRR mutants, show exquisite sensitivity (>1000‐fold), which is also associated with defective RAD51 focus formation. Thus, rad51d cells are broadly deficient in RAD51 focus formation in response to various agents, but this defect is not invariably associated with increased sensitivity. Our results indicate that RAD51 paralogs do not contribute equally to cellular resistance of inhibitors of DNAreplication, and that the RAD51 foci associated with replication inhibition may not be a reliable indicator of cellular resistance to such agents. Environ. Mol. Mutagen. 2012. © 2012 Wiley Periodicals, Inc.
Multiphysics modeling of an induction‐stirred ladle in two and three dimensions
Authors: Pal Mayur , Jönsson Pär 
Published: January 2012

SUMMARYA unified model of an induction‐stirred ladle in two and three dimensions is presented. Induction stirring of molten steel is a coupled multiphysics phenomena involving electromagnetic and fluid flow. Models presented in this paper gives a more accurate description of the real stirring conditions and flow pattern by taking into account the multiphysics behavior of the induction‐stirring process in an induction‐stirred ladle. This paper presents formulation of coupled electromagnetic and fluid flow equations. The coupled electromagnetic and fluid flow equations are solved with the use of the finite element method in two and three dimensions. The model is used to predict values of steel velocities and magnetic flux density. The model is also used to predict the effect of increased current density on flow velocity. Magnetic flux density values obtained from the model are verified against the experimental values. Copyright © 2012 John Wiley & Sons, Ltd.
Gene by neuroticism interaction and cognitive function among older adults
Authors: Dar‐Nimrod Ilan , Chapman Benjamin P. , Robbins John A. , Porsteinsson Anton , Mapstone Mark , Duberstein Paul R. 
Published: January 2012

ObjectivesBoth apolipoprotein E (ApoE) ε‐4 allele(s) and elevated trait neuroticism, the tendency to experience distress, are associated with cognitive function among older adults. We predicted that neuroticism moderates the association between ApoE and cognitive function and also explored whether other personality dimensions (openness to experience, agreeableness, extraversion, and conscientiousness) affect the association between ApoE status and cognitive function.MethodFive‐hundred and ninety‐seven older adults (mean age of 78 years) enrolled in the Ginkgo Evaluation of Memory study completed the NEO five‐factor inventory of personality. Cognitive function was assessed via the cognitive portion of the Alzheimer's Disease Assessment Scale, and a blood sample for ApoE genotyping was drawn.ResultsAs hypothesized, regression analysis indicated that neuroticism moderated the relationship between the presence of ApoE ε‐4 and cognitive function. Individuals with high neuroticism scores had significantly lower scores on the cognitive portion of the Alzheimer's Disease Assessment Scale compared with individuals with low neuroticism scores, but this was true only among carriers of ApoE ε‐4 (interaction effect β = 0.124, p = 0.028). There was scant evidence that other personality dimensions moderate the association between ApoE ε‐4 and cognitive function.ConclusionsCognitive function may be affected by ApoE and neuroticism acting in tandem. Research on the underlying physiological mechanisms by which neuroticism amplifies the effect of ApoE ε‐4 is warranted. The study of genotype by phenotype interactions provides an important and useful direction for the study of cognitive function among older adults and for the development of novel prevention programs. Copyright © 2012 John Wiley & Sons, Ltd.
Zn(OAc)2•2H2O‐catalyzed synthesis of α‐aminophosphonates under neat reaction
Authors: Arigala Uma Ravi Sankar , Matcha Chaitanya , Yoon Kuk Ro 
Published: January 2012

AbstractA series of novel α‐aminophosphonates have been prepared by one‐pot three‐component condensation in the presence of a zinc acetate (Zn(OAc)2•2H2O) catalyst at 50°C under solvent‐free conditions with excellent yields. The major advantages of the present method are high yields, a short reaction time, and solvent‐free reaction conditions. Their antimicrobial activity was evaluated, and some of them showed significant activity. © 2011 Wiley Periodicals, Inc. Heteroatom Chem 23:160–165, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.20765
Thermal conductivity of carbon nanotube nanofluid—Experimental and theoretical study
Authors: Walvekar Rashmi , Faris Ismail Ahmad , Khalid Mohammad 
Published: January 2012

AbstractIn this work, thermal conductivity of carbon nanotubes' (CNTs) nanofluid is studied both experimentally and theoretically. CNT nanofluids were stabilized using gum arabic (GA). The concentration of CNTs was varied from 0.01–0.1 wt% while the concentration of GA was varied from 1–2.5 wt%, respectively. The effect of particle volume fraction and temperature on the thermal conductivity enhancement of the nanofluids was also studied. A simple thermal conductivity model which demonstrates the effect of diameter and aspect ratio of the CNTs and takes into account the effect of temperature on thermal conductivity enhancement is presented. Good agreement between experimental and estimated values proves that the proposed model can provide precise prediction of the thermal conductivity of fluid containing CNTs. © 2012 Wiley Periodicals, Inc. Heat Trans Asian Res; Published online in Wiley Online Library (wileyonlinelibrary.com/journal/htj). DOI 10.1002/htj.20405
MHD flow over an inclined radiating plate with the temperature‐dependent thermal conductivity, variable reactive index, and heat generation
Authors: Aziz A. , Uddin Md. Jashim , Hamad M.A.A. , Md. Ismail A.I. 
Published: January 2012

AbstractWe study the effects of higher‐order chemical reaction and heat generation on coupled heat and mass transfer by MHD mixed convection from a permeable radiating inclined plate with the thermal convective boundary condition. The governing boundary layer equations are formulated and transformed into a set of similarity equations using dimensionless similarity variables developed by Lie group analysis. The resulting equations are then solved numerically using Maple 13 which uses a fourth–fifth order Runge–Kutta–Fehlberg algorithm for solving nonlinear boundary value problems. A representative set of numerical results are displayed graphically and discussed to show some interesting aspects of the parameters: convective heat transfer (γ), the angle of inclination (α), generation order of chemical reaction (n), reaction rate (λ), the Prandtl number (Pr), and the Schmidt number (Sc) on the dimensionless axial velocity, the temperature, and the concentration profiles. Also effects of pertinent parameters on the skin friction factor, the rate of heat, and the rate of mass transfer are obtained and displayed in tabular form. Good agreement is found between the numerical results of the present paper with the earlier published works under some special cases. © 2012 Wiley Periodicals, Inc. Heat Trans Asian Res; Published online in Wiley Online Library (wileyonlinelibrary.com/journal/htj). DOI 10.1002/htj.20409
Refocusing on nature: Holistic assessment of ecosystem services
Authors: Menzie Charles A , Deardorff Thomas , Booth Pieter , Wickwire Ted 
Published: January 2012

Abstract
The benefits people obtain from ecosystems vary from direct benefits that are easily monetized (e.g., timber) to indirect benefits that are not easily monetized (e.g., maintenance of water quality). Commonly, there is wide variation among individuals in the values placed on ecosystem benefits or services. The lack of consensus both in identifying ecosystem services and in valuing them with respect to other services poses a great challenge to those charged with evaluating changes in the provision of ecosystem service after, for example, a natural disaster. Natural resource economics provides some tools, but economics alone will not ensure a balanced, holistic assessment. An inherent complexity in valuing services is often associated with the interrelationships between services and the background and expertise of those leading the assessment. We argue that a holistic evaluation of ecosystems founded on solid expertise in ecosystem dynamics is essential for the accurate assessment of ecosystem services. A reductionist approach to ecosystem service valuation often fails to capture ecological dynamics that are vital to the functioning and ultimate provision of services. In this article, we present case studies of ecosystem services valuation for forest fires, dam removal, and chemical contamination of sediment to explore the complexity of ecosystem service valuation. Additionally, we offer assessment strategies for recognizing the importance of holistic assessment of ecosystem services. Integr Environ Assess Manag 2012; 8: 401–411. © 2012 SETAC
College counseling: between the rock and the hard place
Authors: WARNATH CHARLES F. 
Published: January 2012

Professional counseling in institutions of higher education is facing a serious crisis. The crisis is not due simply to the fact that institutional administrators are asking their professional counselors to account for their activities, nor is it due simply to the fact that professional counselors have lost touch with an increasing proportion of students who are turning to self‐initiated counseling arrangements for their most immediate needs.The crisis of counselor survival arises mainly from the fact that those services that administrators expect professional counselors to perform as part of their organizational role are actually counterproductive to the establishment of trusting and meaningful relationships between counselors and students.