bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the Compatibility Criteria for Protein Encapsulation inside Mesoporous Materials
Authors: Giussani Lara , Fois Ettore , Gianotti Enrica , Tabacchi Gloria , Gamba Aldo , Coluccia Salvatore 
Published: March 2010

AbstractThe properties of the enzyme pepsin, relevant to its incorporation inside the channels of mesoporous silica materials in the preparation of bioinorganic hybrids, are highlighted by molecular dynamics simulations of aqueous solutions of the protein under conditions optimal for encapsulation in SBA‐15. The protein size, shape, flexibility and surface properties are calculated with the aim of deriving general accessibility/compatibility criteria favouring encapsulation inside mesoporous systems.
Be careful what you strive for: the significance of motive–goal congruence for depressivity
Authors: Pueschel Oliver , Schulte Dietmar , Michalak Johannes 
Published: March 2010

AbstractIn a sample of 61 psychotherapy outpatients, the current study investigated the association between progress at motive‐congruent personal goals and depressivity. In a correlational design, motives were measured with a Picture Story Exercise. Personal goals and goal progress were assessed using a self‐report approach. The Beck Depression Inventory was used to determine patients' levels of depressive symptoms. In accordance with Beck's congruency hypothesis, results showed that only motive‐congruent goal progress was related to depressivity. Motive‐incongruent progress could not account for interindividual differences in depressive symptoms. Implications of the findings are discussed in terms of the aetiology of depression and the definition of explicit treatment goals. Copyright © 2010 John Wiley & Sons, Ltd.Key Practitioner Message:• Goal progress per se is not associated with lower levels of depressivity.• Only in combination with implicit motives can goal progress account for interindividual differences in depressivity.• Implicit motives can provide clinicians with important information for the definition of adequate treatment goals.
The value of E‐cadherin/ β‐catenin expression in imprints of NCSLC: Relationship with clinicopathological factors
Authors: Pagaki Eumorfia , Patsouris Efstratios , Gonidi Maria , Athanassiadou Anna‐Maria , Maurikakis Myron , Athanassiades Peter , Chelidonis George , Athanassiadou Pauline 
Published: March 2010

AbstractMetastasis is specific for malignant tumors and its control is one of the most important problems in the design of therapies for cancer patients. Loss or reduction of E‐cadherin expression and/or β‐catenin expression plays a casual role in tumor progression and metastasis and is associated with poor prognosis.The purpose of the study is to investigate the expression of E‐cadherin and β‐catenin and their significance as independent prognostic markers in imprints of resected nonsmall cell lung cancer (NSCLC).Imprint smears from 70 patients who underwent surgical lung resection for primary carcinoma were studied. As control group was used imprints of physiological tissues.Histologically 47 (67.1%) of the tumors were squamous cell carcinomas and 23 (32.9%) were adenocarcinomas. Tumors stage was I in 29 (41.4%), II in 13 (18.6%), III in 24 (34.3%) and IV in 4 (5.7%).Positive expression for E‐cadherin was observed in 44.29% of malignant smears vs 85.71% for control group (P = 0.011). For β‐catenin, positive expression was observed in 42.86% malignant cases vs 85.71% for control group (P = 0.008). Positive expression of E‐cadherin and β‐catenin was observed in moderate and well differentiated tumors (P < 0.0001 for both respectively). Positive E‐cadherin and β‐catenin expression was observed in 70.6% and 76.5% of the cases with negative lymphnode metastasis (P < 0.0001 for both respectively). There was no statistically significant association between histological type, tumor stage, pleural invasion, tumor size (P > 0.05 for all) and E‐cadherin/β‐catenin expression.Reduced E‐cadherin or β‐catenin negative expression relates to dedifferentiation and progression of NSCLC. Diagn. Cytopathol. 2010. © 2010 Wiley‐Liss, Inc.
Cytodiagnosis of secretory carcinoma of the breast: A report on two cases
Authors: Jena Madhusmita , Shariff Shameem 
Published: March 2010

AbstractSecretory carcinoma of the breast is a rare (<1%) low grade breast carcinoma which shows distinct features at histology. Diagnosis of this carcinoma at fine needle aspiration cytology (FNAC) is difficult. Two cases of secretory carcinoma of the breast presenting as a breast mass, one in a 24‐year‐old female and the other in a 40‐year‐old female are reported, highlighting their appearance at FNAC. In both the cases the aspirates were cellular and consisted of clusters and single cells with uniform round nuclei showing minimal nuclear atypia. Most of the cells had moderate to abundant cytoplasm with prominent intracytoplasmic vacuoles. Many cells showed a plasmacytoid appearance and others were binucleate. A typical amphophilic bubbly cytoplasm of the tumor cells was observed. Both cases were confirmed as secretory carcinoma on histology. The differences in cell morphology at FNAC of secretory carcinoma of the breast from other breast carcinomas, and its utility of making a preoperative diagnosis are discussed. Diagn. Cytopathol. 2010;38:921–924. © 2010 Wiley‐Liss, Inc.
A case of papillary carcinoma in a thyroglossal cyst without a carcinoma in the thyroid gland
Authors: Albayrak Yavuz , Albayrak Fatih , Kaya Zülküf , Kabalar Esref , Aylu Belkiz 
Published: March 2010

AbstractThe thyroglossal duct cyst is the most common developmental anomaly of the thyroid gland. We present a patient with a papillary thyroid carcinoma diagnosed after surgical resection of a thyroglossal cyst. The 39‐year‐old patient reported to our hospital due to a swelling of this throat. The results of the ultrasonography were reported as showing multiple nodules in both thyroid lobes, and an ∼3‐cm diameter image in the submental area, in keeping with lymphadenomegalia. In the fine‐needle aspiration cytology (FNAC) evaluation from the nodules in the thyroid, it was observed that the thyrocites with uniform nuclei made up single‐layer groups. FNAC from the thyroglossal cyst, a few histiocytes were observed on a ground with a large number of erythrocytes. The patient was subjected to a total thyroidectomy, pyramidal lobe excision, and total excision of the 3‐cm diameter soft mass, starting at the tip of the pyramidal lobe. The case was diagnosed as papillary thyroid carcinoma in thyroglossal duct cyst with histopathological and immunohistochemical findings. If the thyroglossal channel cyst had been diagnosed preoperatively, total thyroidectomy and a Sistrunk operation would have been performed. For this reason, repeated FNAC, particularly, if performed under ultrasound guidance, may improve the diagnostic value of FNAC. Thus, in such patients, throat ultrasonography must be carried out in expert hands, thin‐needle aspiration biopsy, computerized tomography, and thyroid scintigraphy must be done if necessary, and the necessary treatment protocols carried out after a definite diagnosis. Diagn. Cytopathol. 2011;39:38–41. © 2010 Wiley‐Liss, Inc.
Generation of mice with a conditional null allele of the Jagged2 gene
Authors: Xu Jingxia , Krebs Luke T. , Gridley Thomas 
Published: March 2010

AbstractThe Notch signaling pathway is an evolutionarily‐conserved intercellular signaling mechanism, and mutations in its components disrupt embryonic development in many organisms and cause inherited diseases in humans. The Jagged2 (Jag2) gene, which encodes a ligand for Notch pathway receptors, is required for craniofacial, limb, and T cell development. Mice homozygous for a Jag2 null allele die at birth from cleft palate, precluding study of Jag2 function in postnatal and adult mice. We have generated a Jag2 conditional null allele by flanking the first two exons of the Jag2 gene with loxP sites. Cre‐mediated deletion of the Jag2flox allele generates the Jag2del2 allele, which behaves genetically as a Jag2 null allele. This Jag2 conditional null allele will enable investigation of Jag2 function in a variety of tissue‐specific contexts. genesis 48:390–393, 2010. © 2010 Wiley‐Liss, Inc.
Effect of deposition temperature on the properties of thin polymer films deposited by plasma‐enhanced CVD using cyclo‐hexa‐hydrocarbons as monomers
Authors: Moriki Kazunori , Satoh Tetsuji , Itabashi Atsushi , Yumoto Motoshige 
Published: March 2010

AbstractPlasma CVD is a candidate technology for the fabrication of optical polymer waveguides. It can deposit a film on any surface geometry and any substrate material at a temperature under 200 °C in a vacuum process. It also provides good thickness controllability and uniformity of the deposition film. In the present study, the effects of the deposition temperature on film properties, specifically the refractive index, deposition rate, and molecular structure, are discussed. The refractive index decreases as the deposition temperature rises. The logarithm of the deposition rate increases with the reciprocal of the temperature and the gradient of the deposition rate depends on the relative abundance of double bonds in the monomer source. The gradient does not change when CF4 is used instead of Ar as the gas mixed into the plasma, although the deposition rate increases by a factor of about five. We speculate that the deposition rate increases due to the increase in the abundance precursors produced by the presence of CF4 in the plasma and due to an increased abundance of dangling bonds on the surface of the deposition film caused by F radicals. We further speculate that the precursors incorporated into the polymer are selected on the substrate by the density of adsorption sites and the adsorption energy. © 2010 Wiley Periodicals, Inc. Electron Comm Jpn, 93(4): 27–35, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecj.10171
Microwave absorber properties of magnetic and dielectric composite materials
Authors: Joon An Young , Nishida Ken , Yamamoto Takashi , Ueda Shunkichi , Deguchi Takeshi 
Published: March 2010

AbstractIn recent years, because of rapid progress in wireless technology, microwave absorbers or noise suppressors have become necessary for an environment with safe electromagnetic wave levels. To design microwave absorbers or noise suppressors, it is necessary to have a knowledge of the complex permittivity εr*and permeability εr*. In this report, we present the values of the complex permittivity εr*and permeability µr*for composite materials including a magnetic component (iron, Fe coated with Fe3O4) and a dielectric component (titanium oxide, TiO2) obtained by varying the Fe/TiO2volume fraction ratio. By varying this ratio, we can change the values of the complex permeability (µr*=µ′r−jµ′′r) and complex permittivity (εr*=ε′r−jε′′r). The results are applied to the design of a microwave absorber in order to tailor the reflection loss and the central frequency to particular requirements, for example, the conditions required for ETC (5.8 GHz) use in Japan. © 2010 Wiley Periodicals, Inc. Electron Comm Jpn, 93(4): 18–26, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecj.10206
Compact feed circuit with quarter‐wavelength transmission line matrix controlling beams in three directions including boresight
Authors: Tsuji Masatoshi 
Published: March 2010

AbstractA compact feed circuit with a λ/4 transmission line matrix circuit for use in array antennas to control beams in three directions, including boresight, is presented. The feed circuit antenna is composed of five switches and λ/4 transmission lines, and the feeding matrix circuit yields phase differences of ±90°and 0°. The feed circuit can obtain a reliable output signal, as there is only a small degree of deviation of output signal with variations in the line width. The feed circuit is simulated, fabricated, and evaluated for the ISM band, and the measured characteristics agree well with the results of the simulation. The size of the feed circuit is 45 (H) ×48 (W) ×3 (T) mm. © 2010 Wiley Periodicals, Inc. Electron Comm Jpn, 93(4): 10–17, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecj.10218
Identification of time‐varying Wiener systems with unknown parameters
Authors: Kobayashi Yasuhide , Shiotani Yuzuru , Hikita Shinichi , Nomura Kazuya 
Published: March 2010

AbstractWiener systems which consist of a dynamic linear block followed by a static nonlinear element have been used in numerous applications. In many cases, the system parameters are affected by changes in the environmental conditions. This paper describes a new approach to the on‐line identification of time‐varying Wiener systems. The time‐varying linear parameters and the static nonlinear characteristics are estimated by neural networks which can represent various nonlinear characteristics. The initial states of the linear model in each estimation window are not available in the Wiener systems. Thus, the initial states and the other system parameters are estimated simultaneously by nonlinear optimization techniques. Furthermore, the optimal numbers of hidden units in the neural networks are determined by the minimum description length (MDL) criterion. As a result of simulation by this method, more accurate parameters can be obtained than without estimation of the initial states and MDL. © 2010 Wiley Periodicals, Inc. Electron Comm Jpn, 93(4): 1–9, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecj.10247
Cannabimovone, a Cannabinoid with a Rearranged Terpenoid Skeleton from Hemp (Eur. J. Org. Chem. 11/2010)
Authors: Taglialatela‐Scafati Orazio , Pagani Alberto , Scala Fernando , De Petrocellis Luciano , Di Marzo Vincenzo , Grassi Gianpaolo , Appendino Giovanni 
Published: March 2010

AbstractThe cover picture shows the formula of cannabimovone, a cannabinoid with a rearranged terpenoid skeleton isolated from an industrial strain of hemp derived from the old Italian variety Carmagnola. The trade of this exceptionally tall plant (up to 5–6 m) from the homonymous Piedmontese town at the foot of the Monviso mountain (see the painting at the right) to Marseille in France was at the origin of the French revolutionary song and dance la Carmagnole. The picture shows the cultivation of Carmagnola hemp at the foot of the Vesuvio, exemplifying the collaboration between the Italian groups from Campania and Piedmont who report the discovery of cannabimovone on p. 2067 ff. The authors acknowledge Mrs. Maria Rosa Gaude for the painting, Assocanapa (Carmagnola) and Dr. Nicola Ghietti for the pictures and their help, and Dr. Alberto Massarotti for the cover page design.
The first example of MEEKC‐ICP‐MS coupling and its application for the analysis of anticancer platinum complexes
Authors: Bytzek Anna K. , Reithofer Michael R. , Galanski Mathea Sophia , Groessl Michael , Keppler Bernhard K. , Hartinger Christian G. 
Published: March 2010

AbstractMEEKC is a powerful electrodriven separation technique with many applications in different disciplines, including medicinal chemistry; however, up to now the coupling to highly sensitive and selective MS detectors was limited due to the ion suppressive effect of the commonly used surfactant SDS. Herein, the first example of the coupling of MEEKC to ICP‐MS is presented and an MEEKC method for the separation of Pt(II) and Pt(IV) anticancer drugs and drug candidates was developed. Different compositions of microemulsions were evaluated and the data were compared with those collected with standard ultraviolet/visible (UV/vis) spectroscopy detection. The MEEKC‐ICP‐MS system was found to be more sensitive than MEEKC‐UV/vis and the analysis of UV/vis silent compounds is now achievable. The migration behavior of the Pt(II) and Pt(IV) compounds under investigation is correlated to their different chemical structures.
GADD45α induction in the greenscreen HC indicator assay does not occur independently of cytotoxicity
Authors: Olaharski Andrew J. , Albertini Silvio , Mueller Lutz , Zeller Andreas , Struwe Melanie , Gocke Elmar , Kolaja Kyle 
Published: March 2010

AbstractMammalian chromosomal integrity assays are influenced by cytotoxicity, a phenomenon which impacts data interpretation, assay specificity, and regulatory testing guidelines. Concordance of the GADD45α GreenScreen HC indicator assay to established in vitro and in vivo genetic toxicological assays has previously been described, yet a detailed description in the manner by which cytotoxicity influences its performance has not. Here we present a post‐hoc analysis of a previously tested set of 91 proprietary and nonproprietary compounds investigating the influence of cytotoxicity on GADD45α induction and how varying assay cutoff criteria impacts assay performance. Significant cytotoxicity was identified to accompany the majority (72%) of compounds classified as genotoxic by GADD45α induction. Decreasing the GADD45α genotoxic induction criteria (from a 50 to a 30% increase over solvent controls) resulted in an increased assay sensitivity (from 30 to 68%) and concordance (from 55 to 68%), though a concomitant decrease in specificity was also observed (from 97 to 68%). We conclude that GADD45α induction in the GreenScreen HC indicator assay is influenced by cytotoxicity and that assay performance can be improved if different cutoff criteria are implemented. Environ. Mol. Mutagen. 52:28–34, 2011. © 2010 Wiley‐Liss, Inc.
Effects of PON polymorphisms and haplotypes on molecular phenotype in Mexican‐American mothers and children
Authors: Huen Karen , Barcellos Lisa , Beckman Kenneth , Rose Sherri , Eskenazi Brenda , Holland Nina 
Published: March 2010

AbstractParaoxonase 1 (PON1) prevents oxidation of low‐density lipoproteins and inactivates toxic oxon derivatives of organophosphate pesticides (OPs). More than 250 SNPs have been previously identified in the PON1 gene, yet studies of PON1 genetic variation focus primarily on a few promoter SNPs (−108, −162) and coding SNPs (192, 55). We sequenced the PON1 gene in 30 subjects from a Mexican‐American birth cohort and identified 94 polymorphisms with minor allele frequencies >5%, including several novel variants (six SNPs, one insertion, and two deletions). Variants of the PON1 gene and three SNPs from PON2 and PON3 were genotyped in 700 children and mothers from the same cohort. PON1 phenotype was established using two substrate‐specific assays: arylesterase (AREase) and paraoxonase (POase). Twelve PON1 and two PON2 polymorphisms were significantly associated with AREase activity, and 37 polymorphisms with POase activity; however, only nine were not in strong linkage disequilibrium (LD) with either PON1−108 or PON1192 (r2 > 0.20), SNPs with known effects on PON1 quantity and substrate‐specific activity. Single tagSNPs PON155 and PON1192 accounted for similar ranges of AREase variation compared to haplotypes comprised of multiple SNPs within their haplotype blocks. However, PON155 explained 11–16% of POase activity, while six SNPs in the same haplotype block explained threefold more variance (36–56%). Although LD structure in the PON cluster seems similar between Mexicans and Caucasians, allele frequencies for many polymorphisms differed strikingly. Functional effects of PON genetic variation related to susceptibility to OPs and oxidative stress also differed by age and should be considered in protecting vulnerable subpopulations. Environ. Mol. Mutagen. 52:105–116, 2011. © 2010 Wiley‐Liss, Inc.
Modeling the environmental fate of perfluorooctanoic acid and perfluorooctanoate: An investigation of the role of individual species partitioning
Authors: Webster Eva , Ellis David A. , Reid Liisa K. 
Published: March 2010

Abstract
A multimedia multi-species environmental fate model was developed for the conjugate pair perfluorooctanoic acid (PFOA):perfluorooctanoate (PFO). The model allows assessment of the relative contribution of each individual species, in equilibrium with each other, to the overall environmental movement of the pair. The Lake Ontario (Canada/USA) watershed system was selected for this investigation and is simulated in a single-region, seven-compartment model, including a water surface microlayer, and aqueous aerosol generation and redeposition. Results indicate that in the equilibrated presence of both PFOA and PFO, the environmental fate of the pair can be accomplished by consideration of the physical properties of the neutral acid, which govern the intermedia distribution of the pair, coupled with processes of media advection, such as air or water flow. The role of the anion, while the most populous species in the aqueous phase, appears merely to be as a source of the neutral acid for subsequent partitioning. Thus, when only the bulk aqueous phase anion concentrations are of interest a multimedia fate model is not required because these concentrations are largely predictable from the magnitude of emissions to and the advection of the phase. With neutral species partitioning, all local field measurement concentrations of the conjugate pair, PFO(A), are explained by the model to within approximately an order of magnitude, with the exception of lake sediment solids. Model results indicate that bulk aqueous phase PFO acts as a net source for PFOA to the atmosphere, where it may be subject to long-range transport (LRT). Initial calculations suggest an atmospheric LRT potential for PFO(A) of thousands of kilometers, rendering it comparable to hexachlorobenzene. Environ. Toxicol. Chem. 2010;29:1466–1475. © 2010 SETAC
MiR‐221 and MiR‐222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B, CDKNIC and overall survival
Authors: Wurz Kaitlyn , Garcia Rochelle L. , Goff Barbara A. , Mitchell Patrick S. , Lee Jun Haeng , Tewari Muneesh , Swisher Elizabeth M. 
Published: March 2010

AbstractMicroRNAs are often aberrantly expressed in human neoplasms and are postulated to play a role in neoplastic initiation and progression. miR‐221 and miR‐222 negatively regulate expression of CDKN1B (p27) and CDKN1C (p57), two cell cycle regulators expressed in ovarian surface epithelium and down‐regulated in ovarian carcinomas. We characterized miR‐221 and miR‐222 expression in 49 sporadic high grade ovarian carcinomas and determined whether somatic mutation or epigenetic alterations explained the differences in expression of these miRNAs. We correlated these findings with protein expression of CDKN1B and CDKN1C as assessed by immunohistochemistry. Expression of miR‐221 and miR‐222 were closely correlated with each other (P = 0.0001). Interestingly, a lower ratio of miR‐221 to miR‐222 expression was significantly correlated with worse overall survival (P = 0.01) and remained a significant predictor of overall survival in multivariate analysis using the covariate adequacy of surgical cytoreduction (P = 0.03). Higher miR‐222 and miR‐221 expression were significantly associated with decreased CDKN1C expression (P = 0.009 and 0.01). In contrast, CDKN1B expression was not associated with miR‐221 or miR‐222 expression. Neither somatic mutations nor methylation of the studied region explained the alterations in miR‐221 and miR‐222 expression in most carcinomas. © 2010 Wiley‐Liss, Inc.