bluuebunny/crossref_metadata_2025_split huggingface dataset:
Huge Dentigerous Cyst in the Mandible Treated under Local Anesthesia
Authors: Findik Yavuz , Baykul Timuçin 
Published: June 2012

ABSTRACT
A case of a dentigerous cyst located in the mandible of a 32-year-old male was reported. The patient was consulted to our clinic with complaining discomfort in the retromolar area of the left mandible. Radiographic examination revealed regularly demarcated huge bone resorption in the left molar area. Under local anesthesia, lesion was excised and specimen was sent for pathological examination. Microscopic examination of the excised tissue showed it to be well-circumscribed with fibrous tissues, and the cystic space lined by keratinized epithelium. There was no evidence of recurrence of the cysts. The patient remained in good health during the 1 year follow-up.

How to cite this article
Findik Y, Baykul T. Huge Dentigerous Cyst in the Mandible Treated under Local Anesthesia. Int J Exper Dent Sci 2012;1(1):45-47.
Odontology Concern on Some Specific Odontogenic Problems due to Nuclear Leakage Crisis
Authors: Wiwanitkit Viroj 
Published: June 2012

ABSTRACT
The recent nuclear crisis in Japan leads to concern on its health effect. Although there are many reports on its possible unwanted effects on many systems in human body, the specific report on odontology aspect is limited. In this brief review, the author hereby presents the specific concerns on odontology focus on some specific odontogenic problems due to nuclear leakage crisis.

How to cite this article
Wiwanitkit V. Odontology Concern on Some Specific Odontogenic Problems due to Nuclear Leakage Crisis. Int J Exper Dent Sci 2012;1(1):54-55.
Safe Deprotection Strategy for the Tert‐Butyldimethylsilyl (TBS) Group During RNA Synthesis
Authors: Zewge Daniel 
Published: June 2012

AbstractThis unit describes two protocols for the deprotection of 2′‐O‐TBS groups in oligoribonucleotides under mild conditions. Desilylation using ammonium fluoride is applicable to fully protected “RNA only” substrates and desilylation using potassium fluoride is applicable to “mixed RNA/non‐RNA” substrates. Characterization of products is accomplished using LC/MS, RP HPLC and SAX HPLC. Curr. Protoc. Nucleic Acid Chem. 49:3.21.1‐3.21.11. © 2012 by John Wiley & Sons, Inc.
Efficient Application of Ceramic Membranes for Integrated Process Water Treatment – Case Studies
Authors: Duscher Stefan , Herrmann Kurt , Weyd Marcus , Voigt Ingolf 
Published: June 2012

AbstractKeramische Membranen bieten aufgrund ihrer physikalischen Eigenschaften ein breites Spektrum an Einsatzmöglichkeiten. Im Vergleich zu Polymermembranen zeichnen sich keramische Membranen durch eine deutlich höhere Temperatur‐ und pH‐Wert‐Beständigkeit als auch durch eine hohe mechanische Festigkeit aus. Des Weiteren weisen sie oft deutlich höhere Flussleistungen auf. Aufbauend auf grobporösen rohrförmigen und scheibenförmigen keramischen Trägern wurde eine keramische Nanofiltrationsmembran mit einer Trenngrenze von 450 Dalton entwickelt. Diese wird inzwischen kommerziell hergestellt und ist hinsichtlich der niedrigen Trenngrenze noch immer einzigartig.
Dynamics of olfactory and hippocampal neurogenesis in adult sheep
Authors: Brus M. , Meurisse M. , Gheusi G. , Keller M. , Lledo P.M. , Lévy F. 
Published: June 2012

AbstractAlthough adult neurogenesis has been conserved in higher vertebrates such as primates and humans, timing of generation, migration, and differentiation of new neurons appears to differ from that in rodents. Sheep could represent an alternative model to studying neurogenesis in primates because they possess a brain as large as a macaque monkey and have a similar life span. By using a marker of cell division, bromodeoxyuridine (BrdU), in combination with several markers, the maturation time of newborn cells in the dentate gyrus (DG) and the main olfactory bulb (MOB) was determined in sheep. In addition, to establish the origin of adult‐born neurons in the MOB, an adeno‐associated virus that infects neural cells in the ovine brain was injected into the subventricular zone (SVZ). A migratory stream was indicated from the SVZ up to the MOB, consisting of neuroblasts that formed chain‐like structures. Results also showed a long neuronal maturation time in both the DG and the MOB, similar to that in primates. The first new neurons were observed at 1 month in the DG and at 3 months in the MOB after BrdU injections. Thus, maturation of adult‐born cells in both the DG and the MOB is much longer than that in rodents and resembles that in nonhuman primates. This study points out the importance of studying the features of adult neurogenesis in models other than rodents, especially for translational research for human cellular therapy. J. Comp. Neurol. 521:169–188, 2013. © 2012 Wiley Periodicals, Inc.
The evolution of preference strength under sensory bias: a role for indirect selection?
Authors: Frame Alicia M. , Servedio Maria R. 
Published: June 2012

AbstractEvidence suggests that female preferences may sometimes arise through sensory bias, and that males may subsequently evolve traits that increase their conspicuousness to females. Here, we ask whether indirect selection, arising through genetic associations (linkage disequilibrium) during the sexual selection that sensory bias imposes, can itself influence the evolution of preference strength. Specifically, we use population genetic models to consider whether or not modifiers of preference strength can spread under different ecological conditions when female mate choice is driven by sensory bias. We focus on male traits that make a male more conspicuous in certain habitats—and thus both more visible to predators and more attractive to females—and examine modifiers of the strength of preference for conspicuous males. We first solve for the rate of spread of a modifier that strengthens preference within an environmentally uniform population; we illustrate that this spread will be extremely slow. Second, we used a series of simulations to consider the role of habitat structure and movement on the evolution of a modifier of preference strength, using male color polymorphisms as a case study. We find that in most cases, indirect selection does not allow the evolution of stronger or weaker preferences for sensory bias. Only in a “two‐island” model, where there is restricted migration between different patches that favor different male phenotypes, did we find that preference strength could evolve. The role of indirect selection in the evolution of sensory bias is of particular interest because of ongoing speculation regarding the role of sensory bias in the evolution of reproductive isolation.
Laminin regulates postnatal oligodendrocyte production by promoting oligodendrocyte progenitor survival in the subventricular zone
Authors: Relucio Jenne , Menezes Michael J. , Miyagoe‐Suzuki Yuko , Takeda Shin'ichi , Colognato Holly 
Published: June 2012

AbstractThe laminin family of extracellular matrix proteins are expressed broadly during embryonic brain development, but are enriched at ventricular and pial surfaces where laminins mediate radial glial attachment during corticogenesis. In the adult brain, however, laminin distribution is restricted, yet is found within the vascular basal lamina and associated fractones of the ventricular zone (VZ)‐subventricular zone (SVZ) stem cell niche, where laminins regulate adult neural progenitor cell proliferation. It remains unknown, however, if laminins regulate the wave of oligodendrogenesis that occurs in the neonatal/early postnatal VZ‐SVZ. Here we report that Lama2, the gene that encodes the laminin α2‐subunit, regulates postnatal oligodendrogenesis. At birth, Lama2−/− mice had significantly higher levels of dying oligodendrocyte progenitor cells (OPCs) in the OPC germinal zone of the dorsal SVZ. This translated into fewer OPCs, both in the dorsal SVZ well as in an adjacent developing white matter tract, the corpus callosum. In addition, intermediate progenitor cells that give rise to OPCs in the Lama2−/− VZ‐SVZ were mislocalized and proliferated nearer to the ventricle surface. Later, delays in oligodendrocyte maturation (with accompanying OPC accumulation), were observed in the Lama2−/− corpus callosum, leading to dysmyelination by postnatal day 21. Together these data suggest that prosurvival laminin interactions in the developing postnatal VZ‐SVZ germinal zone regulate the ability, or timing, of oligodendrocyte production to occur appropriately. © 2012 Wiley Periodicals, Inc.
Osteoconduction of impacted porous titanium particles with a calcium‐phosphate coating is comparable to osteoconduction of impacted allograft bone particles: In vivo study in a nonloaded goat model
Authors: Walschot Lucas H. B. , Aquarius René , Schreurs Barend W. , Verdonschot Nico , Buma Pieter 
Published: June 2012

AbstractAims:Impaction grafting restores bone defects in hip arthroplasty. Defects are reconstructed with bone particles (BoP) as substitute materials with adequate mechanical and biological properties are not yet available. Ceramic particles (CeP) have mechanical drawbacks as opposed to porous titanium particles (TiP). In this in vivo study, bone ingrowth and bone volume in coated and noncoated TiP were compared to porous biphasic calcium‐phospate CeP and allograft BoP. Coatings consisted of silicated calcium‐phosphate and carbonated apatite. Materials were implanted in goats and impacted in cylindrical defects (diameter 8 mm) in the cancellous bone of the femur. On the basis of fluorochrome labeling and histology, bone ingrowth distance was measured at 4, 8, and 12 weeks. Cross‐sectional bone area was measured at 12 weeks.Findings:TiP created a coherent matrix of entangled particles. CeP pulverized and were noncoherent. Bone ingrowth in TiP improved significantly by the coatings to levels comparable to BoP and CeP. Cross‐sectional bone area was smaller in CeP and TiP compared to BoP.Conclusions:The osteoconductive properties of impacted TiP with a calcium‐phosphate coating are comparable to impacted allograft bone and impacted biphasic ceramics. A more realistic loaded in vivo study should prove that coated TiP is an attractive alternative to allograft bone. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 100B: 1483–1489, 2012.
Adhesion prevention in an intraperitoneal wound model: Performance of two resorbable hemostats in a controlled study in rabbits
Authors: Hermans Michel H. E. , Brown Lauren , Darmoc Marissa 
Published: June 2012

AbstractAdhesions, particularly in the abdominal and pelvic cavities, represent a significant clinical problem. Among other complications, they are considered the most common cause of intestinal obstructions in the Western world. The purpose of this study was to evaluate two commercially available hemostats for their ability to prevent adhesion formation in an abdominal wound model. The hemostats, a microfibrillar collagen‐based composite and microporous polysaccharide spheres were used in a rabbit abdominal model. In the model the cecum was abraded and a peritoneal defect was created on the abdominal sidewall. The test materials were applied over the defects. Clinical and histological results were compared with control (no application of any hemostat at the defect site) on postoperative day 14.The results showed a significant reduction in the incidence, extent and severity of adhesions for both surgical hemostat materials compared with control. The microfibrillar collagen‐based composite showed a total absence of adhesions and a high level of reperitonealization.This preclinical study suggests that the use of surgical hemostats may help to reduce or eliminate adhesions and may promote reperitonealization. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 100B: 1621–1626, 2012.
Curing behavior of silicone elastomer in the presence of two corticosteroid drugs
Authors: Farahmandghavi Farhid , Imani Mohammad , Mirzadeh Hamid , Jolly Claude 
Published: June 2012

AbstractSilicone rubbers are widely used as carriers for delivery of drugs intended for parenteral administration as implantable devices. Drugs having different functional groups can significantly affect curing profile of silicone rubber, which in turn may negatively affect their biological applicability due to the loss in mechanical and drug retaining properties. To this end, the effects of two corticosteroid analogs (up to 2 %w/w of drug loading) that is, dexamethasone (DEX) and its sodium phosphate ester (DSP) on curing behavior of a non‐restricted, two part RTV silicone rubber was studied using different characterization techniques including spectroscopic (FTIR), calorimetric (DSC), oscillating disk rheometry, and swelling studies. The results showed that curing time extends longer for DSP‐loaded samples compared to the non‐loaded silicone rubber. The presence of DSP in the formulation interferes in the curing of silicone elastomers, probably due to the thermal decomposition of DSP according to the spectral changes observed in FTIR spectra as confirmed by DSC analysis. Rheometric studies showed depreciated properties for silicone elastomers upon compounding with DSP. Swelling measurements indicated to lowered crosslink density for networks and increasing Mc upon adding DSP to the formulations which can be attributed to disruption in crosslinking reaction by sodium phosphate moieties of DSP. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 100B: 1636–1644, 2012.
Influence of pH on the tribocorrosion behavior of CpTi in the oral environment: synergistic interactions of wear and corrosion
Authors: Mathew Mathew T. , Abbey Savithri , Hallab Nadim J. , Hall Deborah J. , Sukotjo Cortino , Wimmer Markus A. 
Published: June 2012

AbstractDental implants made of titanium alloys have been used as a predictable therapy approach to replace missing teeth. The oral environment subjects titanium implants to varying conditions like changes in pH, temperature, and saliva contamination leading to chemical corrosion together with mastication process. Objective: In this study, the combined effect of chemical corrosion and wear (so‐called tribocorrosion) in the degradation of dental implant material (CpTi) under varying pH oral environment was investigated. Methods: Titanium (CpTi) discs were subjected to sliding tests in artificial saliva at varying pHs: 3.0, 6.0, and 9.0. A custom made tribocorrosion apparatus was used to perform the tests. The tribological system consisted of a ceramic ball of 28 mm diameter articulating against the flat face (titanium). Results: Electrochemical impedance spectroscopy results indicated an increase in electrochemical double layer capacitance (Cdl) at pH 3.0 and 6.0 after sliding. Surprisingly, in the presence of tribological stresses, the measured current evolution was highest and fluctuated the most at pH 6.0. In addition, the greatest weight loss was measured at pH 6.0. Conclusions: Despite reports of CpTi being electrochemically stable down to pH 2.0, this study suggests degradation peaks at near neutral pH values in the presence of motion. At pH 6.0, the passive film layer, typically protecting the surface of titanium may not be reformed cohesively, resulting in more tribocorrosion products at the surface, which are easily sheared off. These findings elevate concern with regard to dental implants because the average pH of the oral cavity is 6.3. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 100B: 1662–1671, 2012.
Identification of the unknown transformation products derived from lincomycin using LC‐HRMS technique
Authors: Calza P. , Medana C. , Padovano E. , Dal Bello F. , Baiocchi C. 
Published: June 2012

In this paper, a comprehensive study of the fate of an antibiotic, lincomycin, in the aquatic environment is presented. High‐resolution mass spectrometry was employed to assess the evolution of the process over time. Formation of intermediate compounds was followed by high performance liquid chromatography‐high resolution mass spectrometry (LC‐HRMS); accurate mass‐to‐charge ratios of parent ions were reported with inaccuracy below 1 mmu, which guarantee the correct assignment of their molecular formula in all cases, while their MS2 and MS3 spectra showed several structural‐diagnostic ions that allowed to characterize the different transformation products (TPs) and to discriminate the isobaric species.The simulation of phototransformation occurring in the aquatic environment and the identification of biotic and abiotic TPs of the pharmaceutical compound were carried out in different experimental conditions: dark experiments, homogeneous photolysis and heterogeneous photocatalysis using titanium dioxide, in order to recreate conditions similar to those found in the environment. Twenty‐one main species were identified afterwards lincomycin transformation. Several isomeric species were formed and characterized by analyzing MS and MSn spectra and by comparison with parent molecule fragmentation pathways. The major transformation process for lincomycin is hydroxylation either at N‐alkyl side chain or at the pyrrolidine moiety. In addition, oxidation/reduction, demethylation or cleavage of pyranose ring occurs. Based on this information and additional assessment of profiles over time of formation/disappearance of each species, it was possible to recognize the transformation pathways followed by the drug. Copyright © 2012 John Wiley & Sons, Ltd.
LC‐MS/MS analysis of Δ9‐tetrahydrocannabinolic acid A in serum after protein precipitation using an in‐house synthesized deuterated internal standard
Authors: Wohlfarth Ariane , Roth Nadine , Auwärter Volker 
Published: June 2012

An assay based on liquid chromatography/tandem mass spectrometry is presented for the fast, precise and sensitive quantitation of Δ9‐tetrahydrocannabinolic acid A (THCA) in serum. THCA is the biogenetic precursor of Δ9‐tetrahydrocannabinol in cannabis and has aroused interest in the pharmacological and forensic field especially as a potential marker for recent cannabis use.After addition of deuterated THCA, synthesized from D3‐THC as starting material, and protein precipitation, the analytes were separated using gradient elution on a Luna C18 column (150 × 2.0 mm × 5 µm) with 0.1% formic acid and acetonitrile/0.1% formic acid. Data acquisition was performed on a triple quadrupole linear ion trap mass spectrometer in multiple reaction monitoring mode with negative electrospray ionization. After optimization, the following sample preparation procedure was used: 200 μL serum was spiked with internal standard solution and methanol and then precipitated ‘in fractions’ with 500 μL ice‐cold acetonitrile. After storage and centrifugation, the supernatant was evaporated and the residue redissolved in mobile phase.The assay was fully validated according to international guidelines including, for the first time, the assessment of matrix effects and stability experiments. Limit of detection was 0.1 ng/mL, and limit of quantification was 1.0 ng/mL. The method was found to be selective and proved to be linear over a range of 1.0 to 100 ng/mL using a 1/x weighted calibration model with regression coefficients >0.9996. Accuracy and precision data were within the required limits (RSD ≤ 8.6%, bias: 2.4 to 11.4%), extractive yield was greater than 84%. The analytes were stable in serum samples after three freeze/thaw cycles and storage at −20 °C for one month. Copyright © 2012 John Wiley & Sons, Ltd.
Estimating abundance of mountain lions from unstructured spatial sampling
Authors: Russell Robin E. , Royle J. Andrew , Desimone Richard , Schwartz Michael K. , Edwards Victoria L. , Pilgrim Kristy P. , Mckelvey Kevin S. 
Published: June 2012

AbstractMountain lions (Puma concolor) are often difficult to monitor because of their low capture probabilities, extensive movements, and large territories. Methods for estimating the abundance of this species are needed to assess population status, determine harvest levels, evaluate the impacts of management actions on populations, and derive conservation and management strategies. Traditional mark–recapture methods do not explicitly account for differences in individual capture probabilities due to the spatial distribution of individuals in relation to survey effort (or trap locations). However, recent advances in the analysis of capture–recapture data have produced methods estimating abundance and density of animals from spatially explicit capture–recapture data that account for heterogeneity in capture probabilities due to the spatial organization of individuals and traps. We adapt recently developed spatial capture–recapture models to estimate density and abundance of mountain lions in western Montana. Volunteers and state agency personnel collected mountain lion DNA samples in portions of the Blackfoot drainage (7,908 km2) in west‐central Montana using 2 methods: snow back‐tracking mountain lion tracks to collect hair samples and biopsy darting treed mountain lions to obtain tissue samples. Overall, we recorded 72 individual capture events, including captures both with and without tissue sample collection and hair samples resulting in the identification of 50 individual mountain lions (30 females, 19 males, and 1 unknown sex individual). We estimated lion densities from 8 models containing effects of distance, sex, and survey effort on detection probability. Our population density estimates ranged from a minimum of 3.7 mountain lions/100 km2(95% CI 2.3–5.7) under the distance only model (including only an effect of distance on detection probability) to 6.7 (95% CI 3.1–11.0) under the full model (including effects of distance, sex, survey effort, and distance × sex on detection probability). These numbers translate to a total estimate of 293 mountain lions (95% CI 182–451) to 529 (95% CI 245–870) within the Blackfoot drainage. Results from the distance model are similar to previous estimates of 3.6 mountain lions/100 km2for the study area; however, results from all other models indicated greater numbers of mountain lions. Our results indicate that unstructured spatial sampling combined with spatial capture–recapture analysis can be an effective method for estimating large carnivore densities. Published 2012. This article is a U.S. Government work and is in the public domain in the USA.
A Study of the Authophobic Dewetting in Thin Polymer Films
Authors: Béziel Wilfried , Sferrazza Michele 
Published: June 2012

AbstractWe have investigated the dewetting behaviour of a thin polystyrene film on top of cross‐linked network of the same polymer. By changing the cross‐linking density, the dynamic of the dewetting is modified. The behaviour of the contact angle and dewetting velocity can be related to the interfacial width between the polymers. We observe moreover that while the lost of entropy of the network connected to the penetration of the free chains will favour the dewetting; the possible presence of “connectors” between the layers will tend to stabilize the wetting. By modifying the entropy of the mesh by swelling the cross‐linked system with a reservoir of the same polymer, the mesh is saturated and a stable interface without interdiffusion between the layers is obtained: in this case a constant contact angle and slippage length are obtained. Networks with higher cross‐linking density are more difficult in general to swell – the mesh size is smaller ‐ and the complete saturation is not reached.