bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validity of dynamic contrast-enhanced magnetic resonance imaging of the breast versus diffusion-weighted imaging and magnetic resonance spectroscopy in predicting the malignant nature of non-mass enhancement lesions
Authors: Bayoumi Dalia , Shokeir Farah Ahmed , Karam Rasha , Elboghdady Aya 
Published: May 2024

Abstract
Background
Breast cancer is the commonest cancer affecting women worldwide. So, it is important to accurately detect and classify different breast lesions. Noninvasive methods for tissue characterization have increased interest, particularly for early diagnosis. Non-mass enhancement (NME) breast lesions are described in magnetic resonance imaging (MRI) as the presence of enhancement without space-occupying lesions. Several studies have described that certain characteristics can be used as new indicators of malignancy in breast NME lesions. We aimed to study the role of multiparametric-MRI (Mp-MRI) as diffusion-weighted imaging (DWI) and magnetic resonance spectroscopy (MRS) in assessment of NME lesions and to suggest which one offers the greatest diagnostic accuracy.

Methods
This retrospective study was conducted from March 2017 to December 2023 on 220 NME breast lesions. All lesions were analyzed to study the features of benign and malignant NME lesions using different MRI techniques including dynamic contrast-enhanced MRI (DCE-MRI), DWI, and MRS. Breast MRI was performed at 1.5 Tesla, findings were correlated with histopathological results of all cases.

Results
Patients’ mean age was 46.56 years with 220 NME breast lesions (54 were benign and 166 were malignant). Invasive ductal carcinoma with ductal carcinoma in situ was the most malignant type representing 93 cases. We found that segmental distribution, heterogeneous enhancement, type III curve, restricted diffusion, lower apparent diffusion coefficient, and positive choline peak were more with malignancy (P = 0.008, 0.02, 0.004, 0.001, and < 0.001). We detected that Mp-MRI has higher diagnostic accuracy than DCE-MRI and combined other functional sequences (DWI, MRS), it was 91.2% with sensitivity 89.9%, specificity 87.8%, positive predictive value 89.2%, and negative predictive value 82.2%.

Conclusions
Functional MRI techniques, such as DWI and MRS, can provide helpful information in assessment of NME lesions. They have high diagnostic accuracy, sensitivity, and specificity in characterizing NME breast lesions as benign or malignant. However, DCE-MRI is mandatory for lesion characterization and delineation of its nature and cannot be replaced by them alone in cases of lesion visualization. So, multiparametric-MRI can improve the diagnostic accuracy of NME breast lesions when combined with dynamic contrast-enhanced MRI and can help in reducing negative biopsy rates.
The added value of virtual reality to parent–child interaction therapy: a qualitative study with parents and therapists
Authors: Scherpbier Iza C. A. , Abrahamse Mariëlle E. , Widdershoven Guy A. M. , Belleman Robert G. , Popma Arne , Lindauer Ramón J. L. 
Published: May 2024

Abstract
Background
Virtual reality (VR) is one of the most rapidly growing technological advancements being studied, developed, and implemented in mental health care. It offers a wide array of possibilities that go beyond the traditional ways of providing mental health care services. Many interventions require clients to learn new skills in order for change to occur. Relevant to this study, behavioral parent-training (BPT) interventions are focused on the acquisition of parenting skills in order to change child behavior. VR was added to the Parent–Child Interaction Therapy (PCIT) – a known BPT intervention — as an additional practice tool. In the present study, which is part of a larger study, the qualitative experiences of (PCIT-)VR from both parents’ and therapists’ perspectives are evaluated, as well as their suggestions for implementation.

Method
Semi-structured interviews were conducted with eleven parents. Five therapists participated in a focus group and three additional semi-structured interviews were conducted with therapists. To analyze, a combination of deductive and inductive thematic analysis was used.

Results
Responses from interviews were divided into three categories: (1) parents’ evaluation, (2) therapists’ evaluation, and (3) suggestions for implementation from both parents and therapists. Next to a positive overall experience with PCIT, a large number of parents were also positive about the addition of VR to treatment. Both parents and therapists experienced VR as a useful additional practice tool. The additional practice in VR led to a boost in confidence in using positive parenting skills. There were mixed experiences regarding the ease and immersion of the tool. Suggestions for implementation from both parents and therapists were to make the tool more appealing and realistic, to vary more in VR modules and to improve certain practical aspects.

Conclusion
Adding VR to PCIT is still a pioneering piece of technology within PCIT. The value of this VR tool lies in the provision of the possibility to practice with skills outside of the therapeutic encounter, which has the potential to instill confidence in using those skills. Given the positive experiences regarding PCIT-VR, it is important to further develop the VR tool. We believe that ultimately, PCIT-VR can potentially serve as a customized way for parents to practice what they are taught during the treatment.
Implementation of the World Health Organization's QualityRights initiative in Ghana: an overview
Authors: Osei Akwasi O. , Amissah Caroline , Hanu Samuel Cudjoe , Tawiah Priscilla E. , Brobbey Kwaku A. , Arthur Yaw Amankwah , Ansong Joana , Ohene Sally-Ann , Gyimah Leveana , Kofie Humphrey , Taylor Daniel , Yaro Peter Badimak , Funk Michelle , Drew Natalie , Moro Maria Francesca , Carta Mauro Giovanni , Baingana Florence Kamayonza , Kpesese Victus Kwaku , Orrell Martin , Cole Celline ,   WHO QualityRights Ghana Team
Published: May 2024

BackgroundGlobally, human rights violations experienced by persons with psychosocial, intellectual or cognitive disabilities continue to be a concern. The World Health Organization's (WHO) QualityRights initiative presents practical remedies to address these abuses. This paper presents an overview of the implementation of the initiative in Ghana.AimsThe main objective of the QualityRights initiative in Ghana was to train and change attitudes among a wide range of stakeholders to promote recovery and respect for human rights for people with psychosocial, intellectual and cognitive disabilities.MethodReports of in-person and online training, minutes of meetings and correspondence among stakeholders of the QualityRights initiative in Ghana, including activities of international collaborators, were analysed to shed light on the implementation of the project in Ghana.ResultsIn-person and online e-training on mental health were conducted. At the time of writing, 40 443 people had registered for the training, 25 416 had started the training and 20 865 people had completed the training and obtained a certificate. The team conducted 27 in-person training sessions with 910 people. The successful implementation of the project is underpinned by a committed partnership among stakeholders, strong leadership from the coordinating agency, the acceptance of the initiative and the outcome. A few challenges, both in implementation and acceptance, are discussed.ConclusionsThe exposure of the WHO QualityRights initiative to a substantial number of key stakeholders involved in mental healthcare in Ghana is critical to reducing human rights abuses for people with psychosocial, intellectual and cognitive disabilities.
High AMH Levels Are Associated With Gestational Hypertension in Patients With PCOS who Underwent IVF/ICSI-ET
Authors: Zhang Menghui , Liu Shujun , Zhang Fuli , Shi Hao , Wang Fang , Chen Caihong , Yang Qingling , Dai Shanjun , Liang Yuling , Guo Yihong 
Published: May 2024

Abstract

Background
Patients with polycystic ovary syndrome (PCOS) have a higher risk of obstetric complications. The association between anti-Müllerian hormone (AMH) and gestational hypertension in these patients is poorly understood.

Objective
To determine the association between serum AMH levels and gestational hypertension in patients with PCOS undergoing fresh embryo transfer.

Methods
This retrospective study included 649 patients with PCOS who had singleton live births after undergoing fresh embryo transfers. The association of AMH with gestational hypertension in these patients was estimated before and after propensity score matching.

Results
Patients with gestational hypertension had higher AMH levels than those without gestational hypertension. In single-factor logistic regression, the odds of gestational hypertension increased by 11.7% and 18.6% for every 1ng/mL increase in AMH before and after adjusting for confounding factors (odds ratio [OR], 1.117; 95% CI, 1.025-1.217; P = .012; adjusted OR, 1.186; 95% CI, 1.061-1.327; adjusted P = .003), respectively. The odds of gestational hypertension increased more than 100% (adjusted OR, 2.635; 95% CI, 1.132-6.137; adjusted P = .025) in the 75th percentile group (&gt;9.30 ng/mL) and more than 3 times (adjusted OR, 4.75; 95% CI, 1.672-13.495; adjusted P = .003) in the 90th percentile group (&gt;12.31 ng/mL) compared to the without gestational hypertension group. AMH level was still associated with gestational hypertension after propensity score matching. The area under the curve of AMH predicting gestational hypertension was 0.654 (95% CI, 0.532-0.776; P = .011) with an optimal cutoff value of 11.975 ng/mL.

Conclusion
High serum AMH level prepregnancy (especially at levels &gt;9.30 ng/mL) indicates a high odds of gestational hypertension in patients with PCOS undergoing fresh embryo transfer.
Coexisting RET/PTC and TERT Promoter Mutation Predict Poor Prognosis but Effective RET and MEK Targeting in Thyroid Cancer
Authors: Zhang Wei , Lin Shuhuang , Wang Zhuo , Zhang Wenyong , Xing Mingzhao 
Published: May 2024

Abstract

Context
The role of RET/PTC rearrangement in the clinical outcomes of papillary thyroid cancer (PTC) is controversial and remains to be clearly undefined.

Objective
This work aimed to investigate the role of coexisting RET/PTC rearrangement and TERT promoter mutation in the prognosis and therapeutic targeting in PTC.

Methods
A total of 669 PTC patients with complete clinical follow-up and genetic data were pooled from thyroid cancer data sets TCGA-THCA, MSK-MetTropism, and MSK-IMPACT, from whom 163 patients (112 women and 47 men, 4 unknown) with wild-type (WT) BRAF/RAS were identified, with a median age (interquartile range [IQR]) of 46.00 (33.00-61.00) years and a median follow-up time (IQR) of 16.13 (8.09-27.91) months for comparative genotype cohort analysis of mortality.

Results
There was a significant concurrence index between RET/PTC and TERT promoter mutations, being 2.040 (95% CI, 1.110-3.747; P = .023). Mortality occurred in 5 of 100 (5%) patients harboring neither mutation, 2 of 18 (11.1%) patients harboring a TERT promoter mutation alone, 0 of 31 (0%) patients harboring a RET/PTC alone, and 7 of 14 (50%) patients harboring both genetic alterations, corresponding to hazard ratios (95% CI) of 1 (reference), 2.469 (0.405-14.022), 3.296e-09 (0-inf), and 9.019 (2.635-30.870), respectively, which remained essentially unchanged after adjustment for patient race, sex, and age. Similar results were observed with BRAF/RAS and TERT promoter mutations. Mechanistically, RET/PTC used the MAP kinase pathway to upregulate the mutated TERT, but not the WT TERT, and, correspondingly, targeting RET and MEK could suppress mutated TERT but not the WT TERT.

Conclusion
Coexisting RET/PTC and TERT promoter mutation identify PTC as a unique clinical entity with high mortality, providing new implications for genetic-based prognostication and potential therapeutic targeting of RET and MEK guided by RET/PTC and TERT status.
Genetic regulation of injury-induced heterotopic ossification in adult zebrafish
Authors: Kaliya-Perumal Arun-Kumar , Celik Cenk , Carney Tom J. , Harris Matthew P. , Ingham Philip W. 
Published: May 2024

ABSTRACT
Heterotopic ossification is the inappropriate formation of bone in soft tissues of the body. It can manifest spontaneously in rare genetic conditions or as a response to injury, known as acquired heterotopic ossification. There are several experimental models for studying acquired heterotopic ossification from different sources of damage. However, their tenuous mechanistic relevance to the human condition, invasive and laborious nature and/or lack of amenability to chemical and genetic screens, limit their utility. To address these limitations, we developed a simple zebrafish injury model that manifests heterotopic ossification with high penetrance in response to clinically emulating injuries, as observed in human myositis ossificans traumatica. Using this model, we defined the transcriptional response to trauma, identifying differentially regulated genes. Mutant analyses revealed that an increase in the activity of the potassium channel Kcnk5b potentiates injury response, whereas loss of function of the interleukin 11 receptor paralogue (Il11ra) resulted in a drastically reduced ossification response. Based on these findings, we postulate that enhanced ionic signalling, specifically through Kcnk5b, regulates the intensity of the skeletogenic injury response, which, in part, requires immune response regulated by Il11ra.
The Algorithmic Assignment of Incentive Schemes
Authors: Opitz Saskia , Sliwka Dirk , Vogelsang Timo , Zimmermann Tom 
Published: May 2024

The assignment of individuals with different observable characteristics to different treatments is a central question in designing optimal policies. We study this question in the context of increasing workers’ performance via targeted incentives using machine learning algorithms with worker demographics, personality traits, and preferences as input. Running two large-scale experiments, we show that (i) performance can be predicted by accurately measured worker characteristics, (ii) a machine learning algorithm can detect heterogeneity in responses to different schemes, (iii) a targeted assignment of schemes to individuals increases performance significantly above the level of the single best scheme, and (iv) algorithmic assignment is more effective for workers who have a high likelihood to repeatedly interact with the employer or who provide more consistent survey answers. This paper was accepted by Yan Chen, behavioral economics and decision analysis. Funding: Funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy [Grant EXC 2126/1-390838866]. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.03362 .
Autoimmune myelofibrosis revealing a systemic lupus erythematosus
Authors: Bensalek Fatimaezzahra , Joulal Hajar , Yousfi Jaouad , Zahlane Mouna , Benjilali Leila , Essaadouni Lamiaa 
Published: May 2024

Background: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease, characterised by multi-organ affections. Haematological involvement is a common manifestation of SLE, consisting of autoimmune peripheral cytopenia. Autoimmune myelofibrosis (AIMF) is a rare cause of cytopenia in SLE; it could precede or be concurrent with the diagnosis of SLE. There are few studies that describe this association. Case description: We report a case of AIMF revealing the diagnosis of SLE in a 34-year-old female, presented with episodes of gingival bleeding associated with peripheral inflammatory polyarthralgia, photosensitivity and deterioration of general condition. Clinical examination revealed a soft pitting oedema in the lower limbs. Laboratory investigations showed a pancytopenia, inflammatory biological syndrome, with positive 24-hour proteinuria and anti-native DNA antibodies. A bone marrow biopsy showed diffuse myelofibrosis associated with maturation disorders and no tumour infiltrate. Renal biopsy revealed proliferative glomerulonephritis class III with immune deposits. Conclusion: The association of AIMF with SLE has been rarely reported, and it could be another cause for cytopenia in SLE.
Left anterior descending coronary T-wave inversion pattern (Wellens’ syndrome) associated with myopericarditis and a normal left coronary artery
Authors: Bhagia Geeta , Hussain Nasir , Arty Fnu , Farah Victor , Biederman Robert 
Published: May 2024

Background: Wellens’ syndrome is characterised by a history of chest pain with an abnormal electrocardiogram (EKG), demonstrating biphasic or deeply inverted T waves in leads V2–3 (may extend to involve all precordial and lateral limb leads – the type B Wellens’ pattern). A Wellens’ EKG pattern is considered highly specific for critical stenosis involving the ostial/proximal left anterior descending artery (LAD). However, there are no reported cases of an association of a Wellens’ EKG pattern with myopericarditis. Here, we present such a rare case. Case description: A thirty-one-year-old female with known essential hypertension and psoriatic arthritis presented with a constant, central chest pain radiating to the shoulders and back. The patient’s physical examination was unremarkable at presentation other than elevated blood pressure at 170/68 mmHg. An EKG at presentation demonstrated deep symmetric T-wave inversions in anterolateral leads with elevated high-sensitivity troponin, and an elevated erythrocyte sedimentation rate. The patient was referred to the cardiac catheterisation laboratory for concerns of a Wellens’ EKG pattern; however, invasive angiography demonstrated only obtuse marginal branch disease – no LAD disease was noted. Cardiac magnetic resonance (CMR) imaging confirmed the diagnosis of myopericarditis and absence of myocardial infarction. The patient was medically managed and discharged home in a stable condition. Conclusion: In literature and established clinical practice, the Wellens’ EKG pattern is considered highly concerning for critical ostial/proximal LAD stenosis. However, we now propose that myopericarditis may be considered in a differential diagnosis for this EKG pattern.
Nanocellulose-Phenol Formaldehyde Adhesive System for Engineered Wood Products: Review
Authors: Naghizadeh Zahra , Iglesias Maria C. , Bello Fatimatu , McDonald Armando G. , Via Brian K. , Maughan Michael R. , Peresin Maria S. 
Published: May 2024

Abstract
Incorporating cellulose nanomaterials into wood adhesives has recently been considered for improving sustainability within wood composite panels. The role of nanocellulose in such an application is mainly determined by nanocellulose dimension, form, morphological and physicochemical properties, characteristics of an adhesive system, and chemical interaction of nanocellulose and adhesive, as well as the dispersion and the orientation of nanomaterials in the polymeric matrix of adhesive. Phenol formaldehyde (PF) adhesives have been extensively used in engineered wood products for decades, and concerns about their brittleness led to continued research efforts for modifying the resin. Recently, the developments in the bio-economy and the nanocellulose industry provided new possibilities for PF adhesive modification and its structural reinforcement with a renewable, biodegradable, abundant, and mechanically strengthened resource. This paper aims to review and demonstrate the available research on the development of nanocellulose-reinforced PF as an adhesive matrix for engineered wood products, in particular, plywood, particleboard, and oriented strand board.
Revisiting longitudinal qualitative studies in social work: considerations for design and methodological insights
Authors: de-Toro Ximena , Rubilar Gabriela , Saracostti Mahia 
Published: May 2024

This paper undertakes an analysis and discussion of the methodological challenges and insights derived from three longitudinal qualitative studies, all conducted in Chile during the COVID-19 pandemic and subject to comprehensive theoretical-methodological reflection processes centred on their respective designs. This analysis makes a significant contribution to interdisciplinary discussions within social research, with a particular emphasis on longitudinal trajectories.
First, we present a comparative analysis of three studies in social work, utilising Saldaña’s questions addressing changes and learning in longitudinal studies. The first study explores the labour trajectories of researchers, the second focuses on the educational trajectories of students, and the last examines therapeutic alliance trajectories between social workers and families within the child protection system.
Following this, we delve into the methodological decisions made by the research group during the execution of these longitudinal studies. This encompasses an examination of participant involvement, temporal definitions of the adopted designs, and the most suitable methodological tools for analysing change processes over time. The outcomes of this comparative analysis reveal the distinctive characteristics of the three longitudinal studies, providing insights into how the time dimension is explored within them. We highlight key criteria essential for consideration in longitudinal qualitative research, particularly regarding participants and methodology.
In conclusion, we advocate for an expanded reflection within the realm of longitudinal qualitative methodology, encompassing aspects such as design choices, approaches to data analysis, integration of technology in information processing, and strategies for maintaining participant engagement.
High-accuracy optical vector network analyzer for optical notch and bandpass responses
Authors: Chen Zenghui , Luo Yonggang , Zou Hongwei , Liu Zhisheng , Li Dan 
Published: May 2024

A high-accuracy optical vector network analyzer (OVNA) based on optical carrier-suppressed double sideband (CS-DSB) modulation is proposed and experimentally demonstrated. The ±1st-order sideband signals are generated by CS-DSB modulation and then pass through the symmetric optical device under test (DUT). The band-stop or band-pass responses can be realized by detecting and processing the double frequency of the driven RF signal. Compared with the conventional symmetrical DSB-based OVNA, the measurement accuracy is improved by eliminating the errors caused by the even-order sidebands, and the complexity is reduced as the proposed method with only one step measurement can avoid the complex postprocessing. In addition, the optical carrier is aligned to the center frequency of the DUT by employing the Pound–Drever–Hall (PDH) technique, which provides stable measurement. At the same time, the limitation that the band-pass responses cannot be measured by the traditional single-sideband (SSB)-based OVNA is overcome. Additionally, accurate magnitude and phase responses of the DUT near the optical carrier can be also achieved since the proposed OVNA is optical filter-immune. The proposed method is theoretically analyzed and verified by experiment. A Fabry–Perot (FP) interferometer serves as the symmetric DUT; the band-stop responses in a frequency range of 6 GHz are obtained with a resolution of 1.2 MHz; and the band-pass responses with the range from 0 to 13 GHz offsetting the optical carrier are also obtained. The measurement time can reach up to 30 min with high stability. The proposed OVNA offers enhanced accuracy and a stable approach for applications in photonic systems and other innovations.