bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Intrauterine Diabetes Exposure on the Incidence of End-Stage Renal Disease in Young Adults With Type 2 Diabetes
Authors: Pavkov Meda E. , Hanson Robert L. , Knowler William C. , Sievers Maurice L. , Bennett Peter H. , Nelson Robert G. 
Published: August 2010

OBJECTIVE
We examined the effect of intrauterine diabetes exposure (IDE) on the incidence of diabetic end-stage renal disease (ESRD) in Pima Indians with type 2 diabetes.

RESEARCH DESIGN AND METHODS
Individuals were followed from their first diabetic examination until December 2006, death, ESRD, or age of 45 years.

RESULTS
Among the 1,850 diabetic participants, 102 had IDE. ESRD developed in 57, 5 of whom had IDE. Cumulative incidence of ESRD by age 45 was 19.3% in participants with IDE and 5.1% in those without; the age- and sex-adjusted incidence rate ratio was 4.12 (95% CI 1.54–11.02). After additional adjustment for age at diabetes onset, ESRD incidence was similar in the two groups (incidence rate ratio 1.38, 95% CI 0.45–4.24).

CONCLUSIONS
IDE increases the age- and sex-adjusted incidence of ESRD fourfold in young adults with type 2 diabetes, mediated primarily by the earlier onset of type 2 diabetes in those with IDE.
Sugar-Sweetened Beverages and Risk of Metabolic Syndrome and Type 2 Diabetes
Authors: Malik Vasanti S. , Popkin Barry M. , Bray George A. , Després Jean-Pierre , Willett Walter C. , Hu Frank B. 
Published: August 2010

OBJECTIVE
Consumption of sugar-sweetened beverages (SSBs), which include soft drinks, fruit drinks, iced tea, and energy and vitamin water drinks has risen across the globe. Regular consumption of SSBs has been associated with weight gain and risk of overweight and obesity, but the role of SSBs in the development of related chronic metabolic diseases, such as metabolic syndrome and type 2 diabetes, has not been quantitatively reviewed.

RESEARCH DESIGN AND METHODS
We searched the MEDLINE database up to May 2010 for prospective cohort studies of SSB intake and risk of metabolic syndrome and type 2 diabetes. We identified 11 studies (three for metabolic syndrome and eight for type 2 diabetes) for inclusion in a random-effects meta-analysis comparing SSB intake in the highest to lowest quantiles in relation to risk of metabolic syndrome and type 2 diabetes.

RESULTS
Based on data from these studies, including 310,819 participants and 15,043 cases of type 2 diabetes, individuals in the highest quantile of SSB intake (most often 1–2 servings/day) had a 26% greater risk of developing type 2 diabetes than those in the lowest quantile (none or &lt;1 serving/month) (relative risk [RR] 1.26 [95% CI 1.12–1.41]). Among studies evaluating metabolic syndrome, including 19,431 participants and 5,803 cases, the pooled RR was 1.20 [1.02–1.42].

CONCLUSIONS
In addition to weight gain, higher consumption of SSBs is associated with development of metabolic syndrome and type 2 diabetes. These data provide empirical evidence that intake of SSBs should be limited to reduce obesity-related risk of chronic metabolic diseases.
Microsatellites for the mangrove tree Avicennia germinans (Acanthaceae): Tools for hybridization and mating system studies
Authors: Mori Gustavo M. , Zucchi Maria I. , Sampaio Iracilda , Souza Anete P. 
Published: August 2010

• Premise of the study: We developed a new set of microsatellite markers for the black mangrove Avicennia germinans, to provide new informative tools for further studies of the mating system, interspecific hybridization, and population genetics.• Methods and Results: We used the microsatellite‐enriched library approach to isolate and characterize 25 new primer pairs. Sixteen of them are polymorphic, showing a variable degree of variation in A. germinans, while nine were monomorphic in the samples examined. Eight exhibited private alleles in A. schaueriana.• Conclusions: These results indicate that these new microsatellite markers will be useful molecular tools for further studies of A. germinans and A. schaueriana population genetics, mating systems, and hybridization.
The Absence of IDO Upregulates Type I IFN Production, Resulting in Suppression of Viral Replication in the Retrovirus-Infected Mouse
Authors: Hoshi Masato , Saito Kuniaki , Hara Akira , Taguchi Ayako , Ohtaki Hirofumi , Tanaka Ryo , Fujigaki Hidetsugu , Osawa Yosuke , Takemura Masao , Matsunami Hidetoshi , Ito Hiroyasu , Seishima Mitsuru 
Published: August 2010

AbstractIndoleamine 2,3-dioxygenase, the l-tryptophan–degrading enzyme, plays a key role in the powerful immunomodulatory effects on several different types of cells. Because modulation of IDO activities after viral infection may have great impact on disease progression, we investigated the role of IDO following infection with LP-BM5 murine leukemia virus. We found suppressed BM5 provirus copies and increased type I IFNs in the spleen from IDO knockout (IDO−/−) and 1-methyl-d-l-tryptophan–treated mice compared with those from wild-type (WT) mice. Additionally, the number of plasmacytoid dendritic cells in IDO−/− mice was higher in the former than in the WT mice. In addition, neutralization of type I IFNs in IDO−/− mice resulted in an increase in LP-BM5 viral replication. Moreover, the survival rate of IDO−/− mice or 1-methyl-d-l-tryptophan–treated mice infected with LP-BM5 alone or with both Toxoplasma gondii and LP-BM5 was clearly greater than the survival rate of WT mice. To our knowledge, the present study is the first report to observe suppressed virus replication with upregulated type I IFN in IDO−/− mice, suggesting that modulation of the IDO pathway may be an effective strategy for treatment of virus infection.
Cutting Edge: Association with IκB Kinase β Regulates the Subcellular Localization of Homer3
Authors: Yatherajam Gayatri , Banerjee Pinaki P. , McCorkell Kelly A. , Solt Laura A. , Hanson Eric P. , Madge Lisa A. , Kang Shin , Worley Paul F. , Orange Jordan S. , May Michael J. 
Published: August 2010

Abstract
The signaling and adaptor protein Homer3 plays a role in controlling immune homeostasis and self-reactivity. Homer3 is recruited to the immune synapse (IS) following TCR ligation, although the mechanisms regulating this subcellular localization are unknown. We show that Homer3 specifically associates with a novel ubiquitin-like domain in the IκB kinase (IKK) β subunit of the IKK complex. Homer3 associates with IKKβ in T cells and colocalizes with the IKK complex at the IS. However, Homer3 is not required for IKK activation, as NF-κB signaling is intact in Homer3-deficient T cells. Instead, the IKK complex recruits Homer3 to the IS following TCR engagement, and we present evidence that this association regulates actin dynamics in T cells. These findings identify a novel interaction between two major signaling proteins and reveal an unexpected NF-κB–independent function for the IKK complex in regulating the subcellular localization of Homer3.
Netrin-1 Regulates Th1/Th2/Th17 Cytokine Production and Inflammation through UNC5B Receptor and Protects Kidney against Ischemia–Reperfusion Injury
Authors: Tadagavadi Raghu Kempegowda , Wang Weiwei , Ramesh Ganesan 
Published: August 2010

Abstract
Overwhelming evidence suggests that ischemia–reperfusion injury of the kidney is an inflammatory disease mediated by innate and adoptive immune systems. The neuronal guidance molecule netrin-1 was shown to modulate inflammatory responses. Given that ischemic kidney is particularly prone to reperfusion-elicited inflammation, we sought to determine the function of netrin-1 and its receptor UNC5B in ischemia–reperfusion-induced inflammation. Renal ischemia–reperfusion caused a rapid decrease in serum netrin-1 levels. Administration of recombinant netrin-1 before or after renal ischemia–reperfusion reduced kidney injury, apoptosis, monocyte and neutrophil infiltration, and cytokine (IL-6, IL-1β, and TNF-α) and chemokine (MCP-1, macrophage-derived cytokine, monokine-induced IFN-γ, keratinocyte-derived chemokine, and chemokine with 6 cysteines) production. Analysis for different netrin-1 receptors on leukocytes showed very high expression of UNC5B but not UNC5C, UNC5D, neogenin, or deleted in colorectal cancer. Expression of UNC5A was low. Neutralization of UNC5B receptor reduced netrin-1–mediated protection against renal ischemia–reperfusion injury, and it increased monocyte and neutrophil infiltration, as well as serum and renal cytokine and chemokine production, with increased kidney injury and renal tubular cell apoptosis. Finally, investigation into netrin-1’s effect on CD4 T cell stimulation showed suppression of Th1/Th2/Th17 cytokine (IL-2, IL-6, IL-10, IL-13, IL-17, IFN-γ, IL-4, and TNF-α) production in vitro. Our studies demonstrate that netrin-1 acting through UNC5B receptor reduces renal ischemia–reperfusion injury and its associated renal inflammation.
IL-33 Exacerbates Eosinophil-Mediated Airway Inflammation
Authors: Stolarski Bartosz , Kurowska-Stolarska Mariola , Kewin Peter , Xu Damo , Liew Foo Y. 
Published: August 2010

Abstract
IL-33 has emerged as an important mediator in the immunopathogenesis of allergy and asthma. However, the role of IL-33 in eosinophil-mediated inflammation has not been fully explored. In this article, we report that IL-33 directly stimulates eosinophil differentiation from CD117+ progenitors in an IL-5–dependent manner. Although resting eosinophils expressed moderate levels of the IL-33R α-chain (ST2L), eosinophils that accumulated in the airways of mice with OVA-induced asthma expressed increased amounts of ST2L. In vitro, IL-33 and GM-CSF are potent inducers of ST2L expression on eosinophils, and IL-33 induced the production of IL-13, CCL17, and TGF-β by eosinophils. In adoptive-transfer experiments, IL-33 exacerbated eosinophil-mediated airway inflammation by increasing the levels of eosinophils, macrophages, lymphocytes, IL-13, TGF-β, CCL3, CCL17, and CCL24 in the lungs. IL-33 also enhanced the eosinophil-mediated differentiation of airway macrophages toward the alternatively activated macrophage phenotype in an IL-13–dependent manner. Taken together, this study demonstrates that the IL-33/ST2 signaling pathway activates airway eosinophils that exacerbate airway inflammation in an autocrine and paracrine manner.
N-Ethyl-N-Nitrosourea–Induced Mutation in Ubiquitin-Specific Peptidase 18 Causes Hyperactivation of IFN-αβ Signaling and Suppresses STAT4-Induced IFN-γ Production, Resulting in Increased Susceptibility to Salmonella Typhimurium
Authors: Richer Etienne , Prendergast Caitlin , Zhang Dong-Er , Qureshi Salman T. , Vidal Silvia M. , Malo Danielle 
Published: August 2010

Abstract
To deepen our knowledge of the natural host response to pathogens, our team undertook an in vivo screen of mutagenized 129S1 mice with Salmonella Typhimurium. One mutation affecting Salmonella susceptibility was mapped to a region of 1.3 Mb on chromosome 6 that contains 15 protein-coding genes. A missense mutation was identified in the Usp18 (ubiquitin-specific peptidase 18) gene. This mutation results in an increased inflammatory response (IL-6, type 1 IFN) to Salmonella and LPS challenge while paradoxically reducing IFN-γ production during bacterial infection. Increased STAT1 phosphorylation correlated with impaired STAT4 phosphorylation, resulting in overwhelming IL-6 secretion but reduced IFN-γ production during infection. The reduced IFN-γ levels, along with the increased inflammation, rationalize the S. Typhimurium susceptibility in terms of increased bacterial load in target organs and cytokine-induced septic shock and death.
Secondary Immunization Generates Clonally Related Antigen-Specific Plasma Cells and Memory B Cells
Authors: Frölich Daniela , Giesecke Claudia , Mei Henrik E. , Reiter Karin , Daridon Capucine , Lipsky Peter E. , Dörner Thomas 
Published: August 2010

Abstract
Rechallenge with T cell-dependent Ags induces memory B cells to re-enter germinal centers (GCs) and undergo further expansion and differentiation into plasma cells (PCs) and secondary memory B cells. It is currently not known whether the expanded population of memory B cells and PCs generated in secondary GCs are clonally related, nor has the extent of proliferation and somatic hypermutation of their precursors been delineated. In this study, after secondary tetanus toxoid (TT) immunization, TT-specific PCs increased 17- to 80-fold on days 6–7, whereas TT-specific memory B cells peaked (delayed) on day 14 with a 2- to 22-fold increase. Molecular analyses of VHDJH rearrangements of individual cells revealed no major differences of gene usage and CDR3 length between TT-specific PCs and memory B cells, and both contained extensive evidence of somatic hypermutation with a pattern consistent with GC reactions. This analysis identified clonally related TT-specific memory B cells and PCs. Within clusters of clonally related cells, sequences shared a number of mutations but also could contain additional base pair changes. The data indicate that although following secondary immunization PCs can derive from memory B cells without further somatic hypermutation, in some circumstances, likely within GC reactions, asymmetric mutation can occur. These results suggest that after the fate decision to differentiate into secondary memory B cells or PCs, some committed precursors continue to proliferate and mutate their VH genes.
ChemInform Abstract: Band Structure Calculations of Ferromagnetic Chromium Tellurides CrSiTe3 and CrGeTe3.
Authors: SIBERCHICOT B. , JOBIC S. , CARTEAUX V. , GRESSIER P. , OUVRARD G. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Crystal Structure, Magnetism, and Phase Transformation in Perovskites A2CrNbO6 (A: Ca, Sr, Ba).
Authors: CHOY J.‐H. , HONG S.‐T. , CHOI K.‐S. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Examination of the Corrugated Surfaces of NbTe2 and WTe2 by Scanning Tunneling and Atomic Force Microscopy.
Authors: BENGEL H. , CANTOW H.‐J. , MAGONOV S. N. , JUNG D. , REN J. , WHANGBO M.‐H. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Crystal Structure, Electronic Band Structure, Electrical Resistivity, and Scanning Probe Microscopy Studies of Layered Compound MoOCl2.
Authors: ZOENNCHEN P. , THIELE G. , HESS C. , SCHLENKER C. , BENGEL H. , CANTOW H.‐J. , MAGONOV S. N. , SEO D.‐K. , WHANGBO M.‐H. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Pressure Dependence of the Heat of Fusion and Melting Temperature of Indium.
Authors: HOEHNE G. W. H. , DOLLHOPF W. , BLANKENHORN K. , MAYR P. U. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Study of the Phase Transitions in Ba(OH)2, and a Comment on the Fusion of Sr(OH)2.
Authors: CORDFUNKE E. H. P. , BOOIJ A. S. , KONINGS R. J. M. , VAN DER LAAN R. R. , SMIT‐GROEN V. M. , VLAANDEREN P. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electrosynthesis and Electrochemical Behavior of Unusual Solid Thallium‐Based Phases: Thallium Peroxide, Thallium(I)‐Thallium(III) Mixed Oxide, Thallium Cuprate, and Thallium Oxyfluoride.
Authors: TSIRLINA G. A. , PETRII O. A. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stationary Kinetics of Essential Reactions on Automobile Exhaust Pt‐Rh/ Al2O3 Catalyst.
Authors: MANNILA P. , SALMI T. , HAARIO H. , LUOMA M. , HAERKOENEN M. , SOHLO J. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation, Characterization, and Testing of Newly Developed Titania‐ Supported V‐P‐O Catalysts.
Authors: OVERBEEK R. A. , WARRINGA P. A. , CROMBAG M. J. D. , VISSER L. M. , VAN DILLEN A. J. , GEUS J. W. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structural State of Boron in MFI‐Titanium Boralites and Their Catalytic Properties.
Authors: ON D. T. , KAPOOR M. P. , BONNEVIOT L. , KALIAGUINE S. , GABELICA Z. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Investigation of Montmorillonite‐Based Clays in the Preparation of Supported Ferric Nitrate.
Authors: BEKASSY S. , CSERI T. , BODAS Z. , FIGUERAS F. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel Microporous Titanium‐Niobium‐Silicates with the Structure of Nenadkevichite.
Authors: ROCHA J. , BRANDAO P. , LIN Z. , KHARLAMOV A. , ANDERSON M. W. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electrochemical Deacetylation of 1,3‐Dicarbonyl Compounds.
Authors: FUJIMOTO K. , MAEKAWA H. , MATSUBARA Y. , NISHIGUCHI I. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Catalytic Action of Azolium Salts. Part 7. Azolium Salts as Effective Catalysts for Benzoin Condensation and Related Reactions.
Authors: MIYASHITA A. , SUZUKI Y. , KOBAYASHI M. , KURIYAMA N. , HIGASHINO T. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Lipase‐Catalyzed Resolution of Chiral Acids or Alcohols Using Mixed Carboxylic‐Carbonic Anhydrides.
Authors: GUIBE‐JAMPEL E. , CHALECKI Z. , BASSIR M. , GELO‐PUJIC M. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reaction of 1,2‐Diketones with N,N‐Dimethylcyanamide in the Presence of Titanium(IV) Chloride.
Authors: MAZIK M. , BOESE R. , SUSTMANN R. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Lanthanum Trifluoromethanesulfonate (La(OTf)3) Promoted Indium‐ Mediated Coupling of Ethyl 4‐Bromocrotonate with Carbonyl Compounds in Water.
Authors: DIANA S.‐C. H. , SIM K.‐Y. , LOH T.‐P. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nitroactivated Double Bonds in Pd(0)‐Catalyzed (3 + 2) Cycloaddition Reactions.
Authors: HOLZAPFEL C. W. , VAN DER MERWE T. L. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Synthetic Method for Perfluorocycloimines.
Authors: NISHIDA M. , FUKAYA H. , ABE T. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Versatile 2‐Fluoroacrylic Building Blocks for the Synthesis of Fluorinated Heterocyclic Compounds.
Authors: SHI G. , WANG Q. , SCHLOSSER M. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.