bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between Bunina bodies and TDP‐43 inclusions in spinal anterior horn in amyotrophic lateral sclerosis
Authors: Mori F. , Tanji K. , Miki Y. , Kakita A. , Takahashi H. , Wakabayashi K. 
Published: March 2010

F. Mori, K. Tanji, Y. Miki, A. Kakita, H. Takahashi and K. Wakabayashi (2010) Neuropathology and Applied Neurobiology36, 345–352 Relationship between Bunina bodies and TDP‐43 inclusions in spinal anterior horn in amyotrophic lateral sclerosis Aims: Amyotrophic lateral sclerosis (ALS) is characterized by upper and lower motor neurone involvement with Bunina bodies (BBs) and TDP‐43 inclusions. To elucidate the relationship between BBs and TDP‐43 inclusions, we examined the spinal cord from 18 patients with ALS. Methods: Five serial sections from lumbar cord were first stained with haematoxylin and eosin to detect BBs and subsequently immunostained with anti‐TDP‐43 antibody. Immunoelectron microscopy was performed on vibratome sections from two cases of ALS. Results: BBs were found in 15 out of 18 cases. TDP‐43 inclusions were found in all the cases. The average incidence of anterior horn cells with BBs and TDP‐43 inclusions relative to the total number of neurones was 17.1% and 46.4%, respectively. The concurrence of both inclusions in the same neurones was found in 15 cases. The incidence of co‐localization of BBs and TDP‐43 inclusions was 15.7% of total neurones. The frequency of TDP‐43 inclusions was significantly higher in neurones with BBs than in those without. Ultrastructurally, TDP‐43‐immunoreactive filamentous structures were intermingled with early‐stage BBs, but not associated with advanced‐stage BBs. Conclusion: These findings suggest that there is a close relationship in the occurrence between BBs and TDP‐43 inclusions.
Weed‐poplar competition dynamics and yield loss in Italian short‐rotation forestry
Authors: OTTO S , LODDO D , ZANIN G 
Published: March 2010

Otto S, Loddo D & Zanin G (2010). Weed‐poplar competition dynamics and yield loss in Italian short‐rotation forestry. Weed Research50, 153–162.SummaryIn recent years there has been increasing interest in short‐rotation poplar plantations for biomass production and cropping techniques and weed control strategies are being developed. Slow initial poplar growth can favour weed infestation and so there is a need for appropriate timing of weed control, based on an understanding of the competitive relationship and dynamics between poplar and weeds. A field experiment with annual and biennial crop cycles was conducted over two years. A 35 cm wide within‐row weedy strip was allowed to develop as the basis for competition. Yield data were fitted with sigmoidal equations, in order to find the critical point (CP) and critical period of weed control (CPWC), using thermal time as the independent variable. Results showed that poplar is very sensitive to weed competition, especially in the first growing season after planting or cutting, and that competition can cause important yield losses. In the annual cycle, the CP corresponds to a yield loss of 26% and 8% in the first and second growing season respectively; in the biennial cycle the CP corresponds to a yield loss of 29%. Furthermore, the CPWC is long. For example, in the first year, based on a 5% yield loss, it lasts from 30 to 84 days after planting. This makes effective weed control difficult to achieve only using a pre‐emergence herbicide, and thus necessitates a post‐emergence treatment, either with herbicides or inter‐row cultivation. These results, together with the inability of the crop to recover from damage, mean that resources must be invested in weed control soon after the beginning of the cropping cycle.
The current and future potential geographical distribution of Hyparrhenia hirta
Authors: CHEJARA V K , KRITICOS D J , KRISTIANSEN P , SINDEL B M , WHALLEY R D B , NADOLNY C 
Published: March 2010

Chejara VK, Kriticos DJ, Kristiansen P, Sindel BM, Whalley RDB & Nadolny C (2010). The current and future potential geographical distribution of Hyparrhenia hirta. Weed Research50, 174–184.Summary Hyparrhenia hirta is a pasture grass that has become highly invasive in several parts of the world, including Australia where it has become a serious environmental weed in recent decades. Knowledge of the likely potential distribution and relative abundance of this invasive species, under current and future climate scenarios, will help biosecurity and weed control authorities to plan better strategies to manage the invasion. The CLIMEX modelling package was used to investigate the impacts of climate change on the potential global distribution of H. hirta, based on eco‐physiological data. The worldwide potential distribution of H. hirta under current climatic conditions is vast and far greater than the current distribution, with suitable climate conditions extending over much of the tropics and subtropics. Under future climate scenarios, the range of H. hirta is likely to expand into areas currently too cold for its survival and contract from areas that are projected to become hotter and drier under climate change. The effects of likely climatic scenarios on the global potential distribution of H. hirta are sufficiently great that they should be considered routinely in strategic control plans for biotic invasions. Changes in the potential range of an invasive species such as H. hirta, under global warming scenarios, will mean that it could invade new jurisdictions. Knowledge of this emerging threat could help to formulate effective prevention, surveillance and response measures in these presently marginally unsuitable regions.
Weed community dynamics in two pastures grown after clearing Brazilian Amazonian rainforest
Authors: MITJA D , MIRANDA I S 
Published: March 2010

Mitja D & Miranda IS (2010). Weed community dynamics in two pastures grown after clearing Brazilian Amazonian rainforest. Weed Research50, 163–173.SummaryTo explain the dynamics of the weed vegetation in the Amazonian pastures after clearing of the rainforest, the diversity and floristic composition of 15 Brachiaria brizantha pastures and seven Panicum maximum pastures of various ages were studied. These pastures reflect the original forest, from which they retain a high species richness (from 20 to 73 species on average per 50 m2), a high proportion of forest woody species (from 26% to 65%) and rare species (>50%). The four ecological groups of plants, namely forest woody species, pioneer/secondary woody species, forest herbaceous species and secondary herbaceous species, are present in all pastures immediately after the clearing and burning of the forest and have to compete with the two sown forage species, B. brizantha and P. maximum. Because of its erect habit, P. maximum is rapidly invaded by secondary herbaceous weeds, whereas B. brizantha with its spreading habit slows down their proliferation, which therefore takes about 10 years to complete. The study showed the importance of factors such as the initial vegetation, manual‐clearing practices, duration of cropping and species grown in influencing the floristic composition of the pastures and on the diversity of weeds. These results show the response of weeds faced with human disturbance. The results also demonstrate that farmers can manage pastures in a spirit of conservation of diversity or for weed control.
X‐Linked reticulate pigmentary disorder in a female patient
Authors: Kim Byung Soo , Seo Sang‐Hee , Jung Hong Dae , Kwon Kyung‐Sool , Kim Moon‐Bum 
Published: March 2010

AbstractBackground  X‐Linked reticulate pigmentary disorder is a very rare cutaneous condition characterized by different clinical manifestations according to sex.Methods  We report a 31‐year‐old woman with X‐linked reticulate pigmentary disorder.Results  On examination, there were multiple, asymptomatic, brownish macules in linear and whorled patterns over the trunk, axillae, groin, and extremities. The woman had not experienced any systemic manifestations involving the gastrointestinal, pulmonary, or ocular systems. Her hair, teeth, and nails were normal on close observation. All laboratory data were within the normal range. A genetic study was not performed.Conclusions  Although a genetic study was not performed, we believe that our patient can be diagnosed with X‐linked reticulate pigmentary disorder according to the clinical and histopathologic findings.
Gouty panniculitis in a 68‐year‐old man: case report and review of the literature
Authors: Weberschock T. , Gholam P. , Hartschuh W. , Hartmann M. 
Published: March 2010

AbstractBackground  Gouty panniculitis is a very rare disease. To date, only eight patients have been reported. In each case, time to diagnosis was lengthy. We describe a 68‐year‐old man with a 6‐month history of tender, erythematous plaques and nodules involving the anterior aspects of the legsMethods and results  Histologic examination led to the diagnosis of gouty panniculitis.Conclusion  Review of the literature and the present case suggests that hyperuricemia is a necessary but probably not sufficient condition for gouty panniculitis. Why gouty panniculitis very seldom arises as a manifestation of gout is puzzling. In almost all reported patients, uricostatic or uricosuric therapy leads to clinical improvement of the disease.
Prenatal diagnosis of genodermatoses: current scope and future capabilities
Authors: Luu Minnelly , Cantatore‐Francis Julie L. , Glick Sharon A. 
Published: March 2010

AbstractThe genodermatoses encompass a range of inheritable skin diseases that may be associated with significant mortality and long‐term morbidity. In the past, options for prenatal diagnosis of these diseases were limited to fetal skin biopsy. As a result of recent leaps made in genetics and molecular biology, DNA‐based prenatal diagnosis is now available for an increasing number of genodermatoses, and newer non‐invasive methods are being developed that have the potential for tremendous future impact in dermatology. Dermatologists caring for patients with genodermatoses should be aware of the options for screening and prenatal testing and partake in a multi‐disciplinary approach to patient care.
Basal cell carcinoma in a series of renal transplant recipients: epidemiology and clinicopathologic features
Authors: Mertz Kirsten D. , Proske Dörthe , Kettelhack Natascha , Kegel Christian , Keusch Gérald , Schwarz Albin , Ambühl Patrice M. , Pfaltz Madeleine , Kempf Werner 
Published: March 2010

AbstractBackground  Basal cell carcinoma (BCC) is the most common malignancy among Caucasians worldwide. The risk of BCC is 10–16 times higher among immunosuppressed transplant recipients compared with the general population.Objective  To analyze the incidence, clinical presentation, histologic features, treatment and recurrence rate of BCC in a cohort of 69 renal transplant recipients (RTRs; 53 male).Methods  Retrospective population‐based cohort study of immunosuppressed RTRs.Results  Ten of 69 patients (14.5%, five male) developed a total of 17 BCCs, mostly on the head. Mean age at first diagnosis of BCC was 65.5 ± 8.5 years, and latency between kidney transplantation and diagnosis of the first BCC was 11.1 ± 6.3 years (mean ± SD). The risk of female RTRs to develop BCCs appeared to be three times higher than the risk of male RTRs, and female RTRs developed BCCs earlier after transplantation. Nodular BCC was the most common histologic subtype. Most BCCs in these RTRs were treated by complete surgical excision. Recurrence after surgical excision was observed in one of the 10 patients (10%).Conclusion  Our results suggest female RTRs to be at higher risk to develop cutaneous BCCs than male RTRs. There are no differences in localization and clinicopathologic presentation of BCCs developing in RTRs compared with immunocompetent patients. Therefore, BCCs in RTRs do not require different treatment than in other patient groups. As patients tend to develop a second BCC, close follow‐up is mandatory.
Hailey‐Hailey disease in Tunisia
Authors: Benmously‐Mlika R. , Bchetnia M. , Deghais S. , Ben Brick S.A. , Charfeddine C. , Debbiche A. , Haouet S. , Mokni M. , Abdelhak S. , Kamoun M.R. , Ben Osman A. , Fenniche S. , Mokhtar I. 
Published: March 2010

SummaryBackground  Most of the published reports on Hailey‐Hailey disease (HHD) come from European and Asian countries. We report here the clinical and genetic investigation of 20 patients affected with HHD in Tunisia.Methods  Affected individuals from three large teaching hospitals in Tunis were recruited for the study over a 25‐year period. Nine patients were identified through the active files and examined together with their family members that were visited in their respective regions. We have clinically examined in total 65 individuals and then identified 11 new cases. Patients were included on the basis of evocative skin lesions, biopsy proven HHD and negative immunofluorescence. Investigations to rule out fungal, bacterial and viral infections were done according to clinical symptoms.Results  Twenty patients (12 males and 8 females) from 8 families were included in the present study with more than 55% that were undiagnosed before this investigation. Four patients had mild disease, eight had moderate disease and another eight had severe disease, among whom seven were females. Parental consanguinity was found in 7 cases out of 20 cases (35%). The neck region was first affected in half (4/8) of the male patients. Groins were first affected in 42% (5/12) of the female patients. Depression complicated the course of the disease in two female patients with severe HHD. We report an original association of supernumerary nipples with HHD in two sisters from the north of Tunisia. In 10 patients, the disease has become less troublesome with aging.Conclusion  HHD is underestimated. Physicians must be aware of this disease in case of resistant intertriginous dermatosis especially with a positive family history as nine out of 20 patients were misdiagnosed.
THIS ARTICLE HAS BEEN RETRACTED: Acalculous candidal cholecystitis after pediatric renal transplant
Authors: Grosser Jennifer , Solomon Harvey , Sotelo‐Avila Cirilo 
Published: March 2010

Grosser J, Solomon H, Sotelo‐Avila C. Acalculous candidal cholecystitis after pediatric renal transplant. Pediatr Transplantation 2011: 15: E71–E75. © 2010 John Wiley & Sons A/S.Abstract:  AAC caused by Candida is an uncommon entity usually seen in the critically ill. Here, we present the case of an 18‐month‐old renal transplant patient who developed candidal AAC during the post‐operative period. Previous articles have addressed acalculous cholecystitis secondary to a variety of causes, or addressed a wide variety of Candida infections in the biliary tract, but this is the first discussion of cholecystitis caused by Candida without confounding factors such as biliary calculi or multiple pathogens. After the discussion of our patient’s case, we also reviewed the English‐language literature regarding candidal AAC and discussed diagnosis, treatment, and mortality.
Ondansetron is as effective as diphenhydramine for treatment of morphine‐induced pruritus after cesarean delivery
Authors: SIDDIK‐SAYYID S. M. , YAZBECK‐KARAM V. G. , ZAHREDDINE B. W. , ADHAM A. M. B. F. , DAGHER C. M. , SAASOUH W. A. , AOUAD M. T. 
Published: March 2010

Background: Subarachnoid (SA) morphine, highly effective for the management of pain after a cesarean delivery, is associated with a significant incidence of pruritus in up to 80% of patients. No previous study has compared the effectiveness of ondansetron (5‐HT3 antagonist) vs. diphenhydramine (H1 receptor blocker) for the treatment of this side effect.Methods: In this randomized, double‐blind study, 113 patients with a pruritus score 3 or 4 (1=absent; 2=mild, no treatment required; 3=moderate pruritus, treatment required; and 4=severe pruritus) after SA morphine 0.2 mg were assigned to group ondansetron, which received 4 mg intravenously (i.v.) ondansetron, and group diphenhydramine, which received 25 mg i.v. diphenhydramine. Patients who continued to have pruritus ≥3 30 min after the study drug were considered treatment failures and were treated with naloxone 0.04 mg i.v. repeatedly, as well as patients who relapsed. Pain scores, nausea, vomiting, and sedation were determined before and 30 min after the study drugs were administered. Patients were followed up for 24 h.Results: The success rate was comparable between the two groups [40/57 (70%) and 38/56 (70%), P=0.79, in group ondansetron and group diphenhydramine, respectively]. Among the successfully treated patients, the recurrence rates of moderate to severe pruritus were 11/40 (28%) in group ondansetron and 13/38 (35%) in group diphenhydramine, P=0.52. The side effect profile was similar between the two groups.Conclusion: Ondansetron is as effective as diphenhydramine in relieving pruritus caused by SA morphine in patients undergoing a cesarean delivery. However, up to 50% of patients required naloxone either for primary failure or for recurrence.
Vitrification with Glutamine Improves Maturation Rate of Vitrified / Warmed Immature Bovine Oocytes
Authors: Yamada C , Feitosa WB , Simões R , Nicacio AC , Mendes CM , Assumpção MEOA , Visintin JA 
Published: March 2010

ContentsThe current study examined the protective effects of l‐glutamine and cytochalasin B during vitrification of immature bovine oocytes. Oocyte vitrification solution (PBS supplemented with 10% FCS, 25% EG, 25% DMSO and 0.5 m trehalose) was the vitrification control. Treatments were the addition of 7 μg/ml cytochalasin B, 80 mm glutamine or both cytochalasin and glutaminine for 30 s. After warming, oocytes were matured in vitro for 24 h, fixed and stained with Hoechst (33342) for nuclear maturation evaluation. l‐glutamine improved the vitrified/warmed immature bovine oocytes viability (32.8%), increasing the nuclear maturation rates compared to other treatments and the no treatment vitrified control (17.4%). There was, however, no effect of cytochalasin B on in vitro maturation (14.4%).
Fertility in Single‐ovulating and Superovulated Dairy Heifers after Insemination with Low Dose Sex‐sorted Sperm
Authors: An L , Wu Z‐H , Wu Y‐F , Zhang X‐L , Liu X , Zhu Y‐B , Cheng W‐M , Gao H‐M , Guo M , Tian J‐H 
Published: March 2010

ContentsThe present study was performed to test fertility in single‐ovulating and superovulated dairy heifers after insemination with low dose sex‐sorted sperm under field conditions. Some parameters, including the dosage, deposition site and timing, were assessed with the pregnancy rates after artificial insemination (AI). Moreover, the use of oestrus synchronization in combination with sorted sperm was evaluated. Besides that, we also improved the embryo production efficiency in superovulated dairy heifers by optimizing the timing of inseminations and repartitioning the sexed sperm dosage among multiple inseminations. The conception rate (52.8%) in heifers after low dose (2 × 106) insemination with sorted sperm deep into the uterine horn did not differ (p > 0.05) from that (59.6%) of conventional AI (1 × 107 non‐sorted sperm) and that of deep insemination with low dose non‐sorted sperm (57.7%). There was also no difference (p > 0.05) between conception rates after single (51.7%) and double (53.8%) deep insemination with sorted semen. Heifers inseminated with sorted sperm at synchronous oestrus had a lower pregnancy rate (48.1%) than heifers at spontaneous oestrus (53.6%), but this did not reach statistical difference (p > 0.05). The average number of transferable embryos collected in vivo from heifers inseminated with sorted sperm (4.81 ± 2.04) did not differ (p > 0.05) from that obtained from heifers after insemination with non‐sorted sperm (5.36 ± 2.74). Thus, we concluded that the pregnancy rate after deep intra‐uterine insemination with low dose sorted sperm was similar to that of non‐sorted sperm, which was either also deposited at a low dose deep intra‐uterine or into the uterine body. Sychronization of oestrus can be beneficial in combination with sorted sperm to optimize the organization and management of dairy herds. The results from superovulated heifers demonstrated that our insemination regime can be used to obtain a comparable embryo production efficiency with sorted sperm than with non‐sorted sperm.
Does the Amount of Progesterone in Intravaginal Implants Used to Synchronise Oestrus Affect the Reproductive Performance of Brahman Heifers Artificially Inseminated at a Fixed Time
Authors: Phillips NJ , Fordyce G , Burns B , Williams P , Mayer D , Bo GA , McGowan MR 
Published: March 2010

ContentsThe study tested the hypothesis that reduced intravaginal implant progesterone (P4) concentration to synchronise oestrus would increase pregnancy rates to fixed‐time artificial insemination (FTAI) in Bos indicus heifers. Brahman heifers (n = 294; 2 year) were body condition scored (BCS), weighed and scanned for presence of a corpus luteum (CL). Only cyclic heifers were selected and allocated randomly within BCS and 25 kg bodyweight category to one of three P4 treatment groups. On day 10, heifers received a P4 implant (CueMate‐1‐pod, 0.78g P4; CueMate‐2‐pod, 1.56g P4; or CIDR‐B, 1.9g P4), 2 mg oestradiol benzoate (ODB) intramuscularly (IM) and 250 ug cloprostenol IM. At day 2, the implant was removed, 250 ug cloprostenol was injected IM and tail paint applied. The heifers received 1 mg ODB 24 h later and were FTAI 48–54 h after implant removal (day 0). Ten randomly selected heifers per group were blood sampled and scanned at days 10, 2, 0 and 6 to define the P4 profiles pre‐ and post‐FTAI. Heifers were heat‐detected 18–20 days post‐FTAI and oestrous heifers AI’d by the AM/PM rule. Bulls joined the heifers on day 27 post‐FTAI. Transrectal ultrasonography estimated conception date on day 72. Statistical analysis examined the effects of treatment, technician, semen, ovarian status, BCS and liveweight, on pregnancy rate (PR) to FTAI. There was no significant difference (p = 0.362) in PR between treatment groups (CueMate 1‐pod, 36.4%; CueMate 2‐pod, 39.6%: CIDR‐B, 28.3%), but PR was higher in those heifers with increased BCS between FTAI and pregnancy diagnosis (p = 0.005). Thirty‐three per cent of monitor heifers had plasma P4 concentrations of <1 ng/ml on day 6 after FTAI; only 20% of these conceived vs 60% of heifers with P4 ≥ 1 ng/ml. In summary, no significant difference in PR was identified between treatments but good BCS and a rising plane of nutrition were critical to PR of these pure grade Brahman heifers in northern Australia.
Expression of Interleukin (IL)‐1β and IL‐1 Receptors Genes in the Hypothalamus of Anoestrous Ewes after Lipopolysaccharide Treatment
Authors: Herman AP , Misztal T , Herman A ,   Dorota Tomaszewska – Zaremba
Published: March 2010

ContentsThis study was designed to determine the effect of intravenous lipopolysaccharide (LPS) administration on the secretion of interleukin (IL)‐1β and IL‐1 receptors (IL‐1Rs) gene expression in the hypothalamus of anoestrous ewes. Gene expression of IL‐1β and its receptors was assayed by the real‐time polymerase chain reaction. The expression of IL‐1β in the hypothalamus was detected using Western blot. Our results showed that IL‐1β mRNA is transcribed in the ovine hypothalamus. Lipopolysaccharide increased (p ≤ 0.01) the IL‐1β gene expression in the pre‐optic area 2.4‐fold, the anterior hypothalamus (AHA) 3.4‐fold, the medial basal hypothalamus 3.7‐fold and the medial eminence 3.9‐fold. The pro‐form and mature form of IL‐1β protein were found in the hypothalamus after endotoxin injection. In general, the endotoxin also increased more than two times (p ≤ 0.01) the expression of IL‐1 receptor type I (IL‐1R1) and type II (IL‐1R2) genes in the hypothalamus, except the AHA, where the number of IL‐1R2 mRNA was extremely low and not sufficient to the quantitative analysis. These results demonstrate that the peripheral immune/inflammatory challenge increases the IL‐1β expression in the hypothalamus. This endogenous IL‐1β seems to be involved in the modulation of processes which are regulated at the hypothalamic level. One of these processes could be a reproduction.