bluuebunny/crossref_metadata_2025_split huggingface dataset:
Platelet-Rich Plasma Versus Autologous Whole Blood for the Treatment of Chronic Lateral Elbow Epicondylitis
Authors: Thanasas Christos , Papadimitriou George , Charalambidis Charalambos , Paraskevopoulos Ilias , Papanikolaou Athanasios 
Published: August 2011

Background: Chronic lateral elbow epicondylitis is a tendinosis with angiofibrolastic degeneration of the wrist extensors’ origin. Healing of this lesion is reported with the use of autologous blood as well as with platelet-rich plasma (PRP). Purpose: A comparative study of these 2 treatments was conducted in an effort to investigate the possible advantages of PRP. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: Twenty-eight patients were divided equally into 2 groups, after blocked randomization. Group A was treated with a single injection of 3 mL of autologous blood and group B with 3 mL of PRP under ultrasound guidance. A standardized program of eccentric muscle strengthening was followed by all patients in both groups. Evaluation using a pain visual analog scale (VAS) and Liverpool elbow score was performed at 6 weeks, 3 months, and 6 months. Results: The VAS score improvement was larger in group B at every follow-up interval but the difference was statistically significant only at 6 weeks, when mean improvement was 3.8 points (95% confidence interval [CI], 3.1-4.5) in group B (61.47% improvement) and 2.5 points (95% CI, 1.9-3.1) in group A (41.6% improvement) ( P < .05). No statistically significant difference was noted between groups regarding Liverpool elbow score. Conclusion: Regarding pain reduction, PRP treatment seems to be an effective treatment for chronic lateral elbow epicondylitis and superior to autologous blood in the short term. Defining details of indications, best PRP concentration, number and time of injections, as well as rehabilitation protocol might increase the method’s effectiveness. Additionally, the possibility of cost reduction of the method might justify the use of PRP over autologous whole blood for chronic or refractory tennis elbow.
Evaluation of Healthy Choices: A commercial weight loss programme commissioned by the NHS
Authors: Lloyd Amy , Khan Rabia 
Published: August 2011

Aim: The aim of this study is to identify factors that influence successful weight loss in an NHS-funded commercial weight loss programme. Methods: Baseline height, weight, body mass index (BMI), age, gender, address, date of referral, referrer and 12-week attendance and weight were measured. Participants were classified as having achieved successful weight loss if they had > 5% weight loss and ‘completers’ if they had attended at least 10 of the 12 free sessions. Logistic regression analysis was used to estimate predictors of successful weight loss. Predictors tested in regression analyses were initial weight, number of meetings attended, deprivation, age and gender. Results: In total, 2,456 (87%) of referred participants were given vouchers to attend a commercial weight loss programme for 12 weeks. The majority of the participants were female and the mean age group was 45–54 years. Almost half (44%) of all patients referred had > 5% weight loss at 12 weeks. A statistically significant difference was found in the mean weight loss between completers (6.1 kg, SD 3.7) and drop outs (2.2 kg, SD 2.5). Participants who had successful weight loss were significantly more likely to be older, male and in obese class I. They were also significantly more likely to have attended more meetings. Conclusions: Commercial weight loss programmes produce successful weight loss in the short term. There was no difference in successful weight loss between providers and deprivation quintiles. Age, gender, initial BMI and number of meetings attended are all predictors of successful weight loss.
Comparative analyses reveal discrepancies among results of commonly used methods for Anopheles gambiae molecular form identification
Authors: Santolamazza Federica , Caputo Beniamino , Calzetta Maria , Vicente José L , Mancini Emiliano , Petrarca Vincenzo , Pinto João , della Torre Alessandra 
Published: August 2011

Abstract

Background

Anopheles gambiae M and S molecular forms, the major malaria vectors in the Afro-tropical region, are ongoing a process of ecological diversification and adaptive lineage splitting, which is affecting malaria transmission and vector control strategies in West Africa. These two incipient species are defined on the basis of single nucleotide differences in the IGS and ITS regions of multicopy rDNA located on the X-chromosome. A number of PCR and PCR-RFLP approaches based on form-specific SNPs in the IGS region are used for M and S identification. Moreover, a PCR-method to detect the M-specific insertion of a short interspersed transposable element (SINE200) has recently been introduced as an alternative identification approach. However, a large-scale comparative analysis of four widely used PCR or PCR-RFLP genotyping methods for M and S identification was never carried out to evaluate whether they could be used interchangeably, as commonly assumed.

Results
The genotyping of more than 400 A. gambiae specimens from nine African countries, and the sequencing of the IGS-amplicon of 115 of them, highlighted discrepancies among results obtained by the different approaches due to different kinds of biases, which may result in an overestimation of MS putative hybrids, as follows: i) incorrect match of M and S specific primers used in the allele specific-PCR approach; ii) presence of polymorphisms in the recognition sequence of restriction enzymes used in the PCR-RFLP approaches; iii) incomplete cleavage during the restriction reactions; iv) presence of different copy numbers of M and S-specific IGS-arrays in single individuals in areas of secondary contact between the two forms.

Conclusions
The results reveal that the PCR and PCR-RFLP approaches most commonly utilized to identify A. gambiae M and S forms are not fully interchangeable as usually assumed, and highlight limits of the actual definition of the two molecular forms, which might not fully correspond to the two A. gambiae incipient species in their entire geographical range. These limits are discussed and operational suggestions on the choice of the most convenient method for large-scale M- and S-form identification are provided, also taking into consideration technical aspects related to the epidemiological characteristics of different study areas.
Elevated International Normalized Ratio Associated with Use of Dronedarone and Warfarin
Authors: Pogge Elizabeth K , Haber Stacy L 
Published: August 2011

Objective: To describe a case of elevated International normalized ratio (INR) after addition of dronedarone to warfarin therapy. Case Summary: A 72-year-old white female with a history of tinnitus, gastroesophageal reflux disease, and permanent pacemaker implantation was taking warfarin (target INR 2-3) and Sotalol for chronic atrial fibrillation; atorvastatin for hyperlipidemia; and risedronate for osteopenia. Her warfarin therapy had been managed by a nurse-run anticoagulation clinic for several years. During the prior year, her INR had been stable with a weekly dose of warfarin 25 mg. After persistent episodes of atrial fibrillation, the antiarrhythmic agent was changed from Sotalol to dronedarone 400 mg twice daily. Approximately 10 days after starting dronedarone, the INR was 4.6; she stated that there was no bleeding. The warfarin dose was decreased to 20 mg/wk, and the INR remained stable with that dosage for the next 11 months. Discussion: Postmarketing surveillance has revealed cases of increased INR values with or without bleeding in patients taking warfarin who were started on dronedarone. In this case, the Horn Drug Interaction Probability Scale suggested a probable causality for an interaction between dronedarone and warfarin. Based on current knowledge, this interaction may involve an indirect gastrointestinal mechanism and/or a direct pharmacokinetic mechanism. Conclusions: Clinicians should monitor patients who are taking warfarin and dronedarone for INR changes and bleeding episodes about 1 week after initiation of dronedarone. If a significant interaction Is noted, the warfarin dosage should be decreased and the patient should be monitored within 2 weeks to assess the need for further adjustments.
Histopathologic and immunohistochemical lesions in liver of mink infected with Aleutian disease virus
Authors: Valdovska A. , Pilmane M. 
Published: August 2011

Histopathologic and immunohistochemical lesions in liver of mink infected with Aleutian disease virus
Parvovirus of Aleutian disease causes mainly damage to kidneys, but immune complexes deposition and damage may occur also in other organs. In mink farms of Latvia the liver dystrophy or hepatic lipidosis of mink is widely distributed. The goal of this study was to examine probability of liver damage and regeneration of mink infected with Aleutian disease virus. Liver injury was assessed histologically. The mink liver demonstrated inflammation of liver parenchyma and foci of fatty liver. In immunohistochemistry, during liver regeneration the matrix metalloproteinases MMP-9, vascular endothelial growth factor and β-defensin 2 expressions were lower, but MMP-2 and nerve growth factor receptor p75 expression was increased.
Repeat Transabdominal Laparoscopic Encerclage
Authors: Raghuwanshi SR , Shashikala ST , Rao KA 
Published: August 2011

ABSTRACTWe report here the first case of placement of a repeat laparoscopic abdominal cervicoisthmic cerclage by using a suture passer. The report is on a 34-year-old G5P1L1A3with a history of repeated second trimester pregnancy loss with one successful laparoscopic cerclage term LSCS delivery, again underwent repeat laparoscopic abdominal encerclage in present pregnancy at 12 weeks using suture passer suprapubically. Patient underwent procedure safely with blood loss less than 40 ml and discharged after 24 hours of observation without any postoperative complication. Repeat laparoscopic abdominal encerclage can be done safely in previous LSCS patient who had term pregnancy following laparoscopic abdominal cerclage using a simple instrument suture passer without any postoperative complication or discomfort to the patient.
Laparoscopic Myomectomy for Multiple Submucous Myomas
Authors: Sinha Rakesh , Gupta Seema , Kadam Pratima , Sundaram Meenakshi , Sood Nupur , Adlakha Sharda 
Published: August 2011

ABSTRACTWe report an interesting case of multiple submucous fibroids which was removed by laparoscopic myomectomy. The patient presented with severe menorrhagia and a large uterus of clinically 24 weeks size. She was 29 years and nulliparous. The ultrasonography showed multiple echoes in the endometrial cavity. We did a diagnostic hysteroscopy and found the uterine cavity studded with multiple fibroids of varying sizes. We did a laparoscopy and removed 64 submucous fibroids laparoscopically. We report this interesting case where we removed the submucous fibroids laparoscopically in a single sitting. This reduces the complications of hysteroscopic myomectomy for such large and multiple submucous fibroids. Medline search did not reveal any report of laparoscopic removal of submucous fibroids.
Sulfation rates of cycled CaO particles in the carbonator of a Ca‐looping cycle for postcombustion CO2 capture
Authors: Arias B. , Cordero J. M. , Alonso M. , Abanades J. C. 
Published: August 2011

AbstractCalcium looping is an energy‐efficient CO2 capture technology that uses CaO as a regenerable sorbent. One of the advantages of Ca‐looping compared with other postcombustion technologies is the possibility of operating with flue gases that have a high SO2 content. However, experimental information on sulfation reaction rates of cycled particles in the conditions typical of a carbonator reactor is scarce. This work aims to define a semiempirical sulfation reaction model at particle level suitable for such reaction conditions. The pore blocking mechanism typically observed during the sulfation reaction of fresh calcined limestones is not observed in the case of highly cycled sorbents (N > 20) and the low values of sulfation conversion characteristic of the sorbent in the Ca‐looping system. The random pore model is able to predict reasonably well, the CaO conversion to CaSO4 taking into account the evolution of the pore structure during the calcination/carbonation cycles. The intrinsic reaction parameters derived for chemical and diffusion controlled regimes are in agreement with those found in the literature for sulfation in other systems. © 2011 American Institute of Chemical EngineersAIChE J, 2012
A new weighted optimal combination of ANNs for catalyst design and reactor operation: Methane steam reforming studies
Authors: Arcotumapathy Viswanathan , Siahvashi Arman , Adesina Adesoji A. 
Published: August 2011

AbstractCatalyst design and evaluation is a multifactorial multiobjective optimization problem and the absence of well‐defined mechanistic relationships between wide ranging input‐output variables has stimulated interest in the application of artificial neural network for the analysis of the large body of empirical data available. However, single ANN models generally have limited predictive capability and insufficient to capture the broad range of features inherent in the voluminous but dispersed data sources. In this study, we have employed a Fibonacci approach to select optimal number of neurons for the ANN architecture followed by a new weighted optimal combination of statistically‐derived candidate ANN models in a multierror sense. Data from 200 cases for catalytic methane steam reforming have been used to demonstrate the veracity and robustness of the integrated ANN modeling technique. © 2011 American Institute of Chemical Engineers AIChE J, 58: 2412–2427, 2012
Branchial arch defects and 19p13.12 microdeletion: Defining the critical region into a 0.8 M base interval
Authors: Kosaki Kenjiro , Saito Hideyuki , Kosaki Rika , Torii Chiharu , Kishi Kazuo , Takahashi Takao 
Published: August 2011

AbstractWe present a patient with preauricular tags, preauricular and branchial pits, stenosis of the external auditory canals, mild hearing loss, and mild developmental delay who had a de novo 19p13.12 submicroscopic deletion. The size of the deletion was 760‐kb, extending from 15,300,338 to 16,064,271 (hg18; NCBI Build 36.1). Our finding supports the notion that 19p13.12 represents a unique microdeletion syndrome characterized by branchial arch defects and the concept of exclusion mapping indicates that the putative locus for the branchial arch development is included in the 0.8‐Mb interval defined by the deletion in the presently reported patient. © 2011 Wiley‐Liss, Inc.
Individual differences in the effects of mobile phone exposure on human sleep: Rethinking the problem
Authors: Loughran Sarah P. , McKenzie Raymond J. , Jackson Melinda L. , Howard Mark E. , Croft Rodney J. 
Published: August 2011

AbstractMobile phone exposure‐related effects on the human electroencephalogram (EEG) have been shown during both waking and sleep states, albeit with slight differences in the frequency affected. This discrepancy, combined with studies that failed to find effects, has led many to conclude that no consistent effects exist. We hypothesised that these differences might partly be due to individual variability in response, and that mobile phone emissions may in fact have large but differential effects on human brain activity. Twenty volunteers from our previous study underwent an adaptation night followed by two experimental nights in which they were randomly exposed to two conditions (Active and Sham), followed by a full‐night sleep episode. The EEG spectral power was increased in the sleep spindle frequency range in the first 30 min of non‐rapid eye movement (non‐REM) sleep following Active exposure. This increase was more prominent in the participants that showed an increase in the original study. These results confirm previous findings of mobile phone‐like emissions affecting the EEG during non‐REM sleep. Importantly, this low‐level effect was also shown to be sensitive to individual variability. Furthermore, this indicates that previous negative results are not strong evidence for a lack of an effect and, given the far‐reaching implications of mobile phone research, we may need to rethink the interpretation of results and the manner in which research is conducted in this field. Bioelectromagnetics 33:86–93, 2012. © 2011 Wiley Periodicals, Inc.
Microsecond and nanosecond electric pulses in cancer treatments
Authors: Breton Marie , Mir Lluis M. 
Published: August 2011

AbstractNew local treatments based on electromagnetic fields have been developed as non‐surgical and minimally invasive treatments of tumors. In particular, short electric pulses can induce important non‐thermal changes in cell physiology, especially the permeabilization of the cell membrane. The aim of this review is to summarize the present data on the electroporation‐based techniques: electrochemotherapy (ECT), nanosecond pulsed electric fields (nsPEFs), and irreversible electroporation (IRE). ECT is a safe, easy, and efficient technique for the treatment of solid tumors that uses cell‐permeabilizing electrical pulses to enhance the activity of a non‐permeant (bleomycin) or low permeant (cisplatin) anticancer drug with a very high intrinsic cytotoxicity. The most interesting feature of ECT is its unique ability to selectively kill tumor cells without harming normal surrounding tissue. ECT is already used widely in the clinics in Europe. nsPEFs could represent a drug free, purely electrical cancer therapy. They allow the inhibition of tumor growth, and interestingly, nsPEF can target intracellular organelles. However, many questions remain on the mechanism of action of these pulses. Finally, IRE is a new ablation procedure using pulses that provoke the permanent permeabilization of the cells resulting in their death. This technique does not result in any thermal effect, which is its main advantage in current physical ablation technologies. For both the nsPEF and the IRE, the preservation of the normal tissue, which is characteristic of ECT, has not yet been shown and their safety and efficacy still have to be investigated thoroughly in vivo and in the clinics. Bioelectromagnetics 33:106–123, 2012. © 2011 Wiley Periodicals, Inc.
Designing biomaterials for in situ periodontal tissue regeneration
Authors: Sun Hai‐Hua , Qu Tie‐Jun , Zhang Xian‐Hua , Yu Qing , Chen Fa‐Ming 
Published: August 2011

AbstractThe regeneration of periodontal tissue poses a significant challenge to biomaterial scientists, tissue engineers and periodontal clinicians. Recent advances in this field have shifted the focus from the attempt to recreate tissue replacements/constructs ex vivo to the development of biofunctionalized biomaterials that incorporate and release regulatory signals in a precise and near‐physiological fashion to achieve in situ regeneration. The molecular and physical information coded within the biomaterials define a local biochemical and mechanical niche with complex and dynamic regulation that establishes key interactions with host endogenous cells and, hence, may help to unlock latent regenerative pathways in the body by instructing cell homing and regulating cell proliferation/differentiation. In the future, these innovative principles and biomaterial devices promise to have a profound impact on periodontal reconstructive therapy and are also likely to reconcile the clinical and commercial pressures on other tissue engineering endeavors. © 2011 American Institute of Chemical Engineers Biotechnol. Prog., 2012
Significance of interfacet distance, facet joint orientation, and lumbar lordosis in spondylolysis
Authors: Chung Sang‐Bong , Lee Sungjoon , Kim Hoon , Lee Sun‐Ho , Kim Eun Sang , Eoh Whan 
Published: August 2011

AbstractThe aim of this study is to reveal the association between lumbar spondylolysis and several radiologic parameters, which had been suggested to be significant. The authors examine interfacet distance (IFD), facet joint orientation (FJO), and lumbar segmental lordosis (LSL) all together on the basis of lumbar computed tomography (CT) scan of 35 patients with L5 spondylolysis and 36 unaffected control groups. Thirty‐five Korean military recruits, aged 19–23 (mean 20.9 years), were diagnosed as L5 spondylolysis by lumber CT scans. As a control group, 36 male Korean military recruits, aged 18–25 (mean 21.3 years), were reconfirmed as not affected by lumbar spondylolysis by CT scan when they visited our hospital complaining of back pain. This study compares IFD, FJO, and LSL for each lumbar segment between the spondylolytic and unaffected groups. We also propose the use of normal mean data of IFD, FJO, and LSL of lumbar vertebrae from 36 Korean young military recruits because each measurement has power as an absolute value, like data from an osteologic collection in other studies. Comparison of IFD between spondylolytic and unaffected individuals reveals significant differences at the L3, L4, and L5 level (P = 0.0384, P = 0.0219, and P < 0.0001, respectively). In the group of spondylolysis, the increase of IFD from L4 to S1 was less pronounced (P < 0.0001) and the LSL at L5‐S1 was more lordotic (P = 0.0203). Interfacet distance and lumbar lordosis were significantly different between patients with L5 spondylolysis and individuals without pars defect on L5. In the spondylolysis group, and the increase of IFD from L4 to S1 was less pronounced and the LSL at L5‐S1 was more lordotic. Clin. Anat. 25:391–397, 2012. © 2011 Wiley Periodicals, Inc.
Homothiacalix[4]arenes: Synthetic Exploration and Solid‐State Structures
Authors: Thomas Joice , Van Hecke Kristof , Robeyns Koen , Van Rossom Wim , Sonawane Mahendra P. , Van Meervelt Luc , Smet Mario , Maes Wouter , Dehaen Wim 
Published: August 2011

AbstractHomothiacalix[n]arenes have been largely underexposed compared with related (homo)heteracalixarenes, although their inherent structural features are particularly attractive for supramolecular host–guest chemistry. In this contribution, the synthetic macrocyclization protocols that afford homothiacalix[n]arenes have been reinvestigated and optimized, providing straightforward access to the parent homothiacalix[4]arene skeleton. Moreover, inner‐rim (bis and tetrakis) ester functionalization and dimethylenethia bridge oxidation were successfully performed as well. Solution‐phase (variable‐temperature) NMR spectroscopy studies and solid‐state X‐ray structures provided complementary information on the conformational features of the novel macrocycles.