bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surface‐enhanced Raman scattering and theoretical studies of the C‐terminal peptide of the β‐subunit human chorionic gonadotropin without linked carbohydrates
Authors: Aliaga A. E. , Aguayo T. , Garrido C. , Clavijo E. , Hevia E. , Gómez‐Jeria J. S. , Leyton P. , Campos‐Vallette M. M. , Sanchez‐Cortes S. 
Published: September 2010

AbstractRaman and surface‐enhanced Raman scattering (SERS) spectra of the synthetic carboxy terminal peptide of human chorionic gonadatropin β‐subunit free of carbohydrate moieties (P37) are reported. The spectral analysis is performed on the basis of our reported Raman spectrum and SERS data of oligopeptides displaying selected amino acids sequences MRKDV, ADEDRDA, and LGRGISL. SERS samples of P37 were prepared by coating the solid peptide with metal colloids on a quartz slide. This treatment makes possible to obtain high spectral batch to batch reproducibility. Amino acids components of P37 display net charges and hydrophobic characteristics, which are related to particular structural aspects of the adsorbate–substrate interaction. The spectroscopic results are supported by quantum chemical calculations performed by using extended Hückel theory method for a model of P37 interacting with an Ag surface. The P37‐metal interaction is drove by positively charged fragments of selected amino acids, mainly threonine 109, lysine 122, and arginine in positions 114 and 133. Data here reported intend to contribute to the knowledge about the antigen–antibody interaction and to the drugs delivery research area. © 2010 Wiley Periodicals, Inc. Biopolymers 95: 135–143, 2011.
Group psychoeducation for long‐term offender patients with schizophrenia: An exploratory randomised controlled trial
Authors: Aho‐Mustonen Kati , Tiihonen Jari , Repo‐Tiihonen Eila , Ryynänen Olli‐Pekka , Miettinen Raili , Räty Hannu 
Published: September 2010

ABSTRACTBackground Psychoeducation is now commonly provided in forensic settings, but its effectiveness among long‐term offender patients with schizophrenia has not yet been established in randomised controlled trials (RCTs).Aim To test the effects of a brief group psychoeducation programme for offenders with schizophrenia (n = 39) resident in a high‐security hospital (Niuvanniemi Hospital, Finland).Method High‐security hospital patients were randomised into either eight sessions of group psychoeducation or ‘treatment as usual’ (TAU). Outcome measures, made at baseline, immediately post‐treatment, and 3 months after that, included knowledge about illness, insight, compliance, attitudes towards medication, psychiatric symptoms and ward behaviour, self‐esteem, health‐related quality of life and perceived stigma.Results Three months after completing treatment, or an equivalent time under TAU, patients in the intervention group showed a positive treatment effect in terms of knowledge about illness, self‐esteem and insight into the illness. The only possible adverse effect was a slight increase in irritability, but this did not translate into behaviour of concern to staff.Conclusions Our sample size was small, and the findings must be regarded as preliminary, but the positive treatment effect of psychoeducation, and the absence of alarming side effects, suggests a full scale trial would be worthwhile. Most encouraging was that even the most severely ill patients were able to join the groups. Copyright © 2010 John Wiley & Sons, Ltd.
FRET Studies on a Series of BODIPY‐Dye‐Labeled Switchable Resorcin[4]arene Cavitands
Authors: Pochorovski Igor , Breiten Benjamin , Schweizer W. Bernd , Diederich François 
Published: September 2010

AbstractA series of borondipyrromethane (BODIPY)‐dye‐labeled resorcin[4]arene cavitands 1–4 with different lengths of oligo(phenylene–ethynylene) spacers between the dyes and the macrocyclic rim has been synthesized. Their switching behavior from the “vase” to “kite” conformations in bulk solution was examined by both variable‐temperature (VT) NMR and fluorescence spectroscopy. Both VT‐NMR and VT fluorescence resonance energy transfer (FRET) experiments showed that cavitands 1–4 undergo vase‐to‐kite switching at low temperatures. Acid‐triggered switching to the kite conformation was observed by fluorescence spectroscopy. Quantitative evaluation of the FRET data led to the determination of the Förster radius R0=37 Å for the BODIPY‐dye FRET pair and an average cavitand opening angle α=16° in the vase conformation.
ChemInform Abstract: Crystal Structure and Physical Properties of the Quaternary Manganese‐Bearing Pavonite Homologue Mn1.34Sn6.66Bi8Se20.
Authors: Anglin Clarence , Takas Nathan , Callejas Juan , Poudeu Pierre F. P. 
Published: September 2010

AbstractThe title compound is prepared by solid state reaction of the elements (773 K, 72 h) and characterized by single crystal XRD, magnetic susceptibility, thermal and electrical conductivity, thermopower, and IR measurements.
ChemInform Abstract: Phase Relations and Structural Properties of the Ternary Narrow Gap Semiconductors Zn5Sb4In2‐δ (δ = 0.15) and Zn9Sb6In2.
Authors: Wu Yang , Tengaa Andreas , Lidin Sven , Haeussermann Ulrich 
Published: September 2010

AbstractThe Zn‐rich section of the Zn—Sb—In system contains two ternary intermetallic compounds, stable Zn5Sb4In1.85 (I) and metastable Zn9Sb6In2 (II), with closely related crystal structures which are determined by single crystal XRD.
ChemInform Abstract: Synthesis, Characterization, and Quantum‐Chemical Studies of Ni(CN)2MX (M: Rb, Cs; X: Cl, Br).
Authors: Liu Xiaohui , Speldrich Manfred , Koegerler Paul , Dronskowski Richard , Tchougreeff Andrei L. 
Published: September 2010

AbstractThe new two‐dimensional compounds (III) are characterized by single crystal XRD, FT‐IR and UV/VIS spectroscopy, magnetic measurements, and DFT calculations.
ChemInform Abstract: Controlling Stereoselectivity in the Aminocatalytic Enantioselective Mannich Reaction of Aldehydes with in situ Generated N‐Carbamoyl Imines.
Authors: Galzerano Patrizia , Agostino Dario , Bencivenni Giorgio , Sambri Letizia , Bartoli Giuseppe , Melchiorre Paolo 
Published: September 2010

AbstractAn asymmetric anti‐selective Mannich reaction of in situ generated N‐carbamoyl imines with aldehydes is achieved in the presence of diarylprolinol Tms ethers as catalysts.
ChemInform Abstract: One‐Pot Construction of Multiple Contiguous Chiral Centers Using Michael Addition of Chiral Amine.
Authors: Ozeki Minoru , Ochi Shunsuke , Hayama Noboru , Hosoi Shinzo , Kajimoto Tetsuya , Node Manabu 
Published: September 2010

AbstractTandem Michael—aldol, double Michael, and double Michael—aldol reactions with the chiral amine (I) allow efficient and stereoselective access to functionalized amines with up to five contiguous chiral centers in one pot.
ChemInform Abstract: Supported Cobalt Complex‐Catalyzed Conjugate Addition of Indoles, Amines and Thiols to α,β‐Unsaturated Compounds.
Authors: Rajabi Fatemeh , Razavi Sepideh , Luque Rafael 
Published: September 2010

AbstractA supported cobalt complex is successfully used as a reusable catalyst for the Michael addition of thiols (I), amines (VI), and indoles (VIII) to alkenes (II) and (IV) under solvent‐free conditions.
ChemInform Abstract: [2 + 2] Cycloaddition of Electron‐Poor Acetylenes to (E)‐3‐Dimethylamino‐1‐heteroaryl‐prop‐2‐en‐1‐ones: Synthesis of Highly Functionalized 1‐Heteroaroyl‐1,3‐butadienes.
Authors: Bezensek Jure , Kolesa Tanja , Groselj Uros , Wagger Jernej , Stare Katarina , Meden Anton , Svete Jurij , Stanovnik Branko 
Published: September 2010

AbstractSubstrates (I) undergo a microwave‐promoted cycloaddition with DMAD to give cyclobutene intermediates which afford the desired functionalized 1,3‐dienones after ring opening.
ChemInform Abstract: Synthesis and Antipsychotic and Anticonvulsant Activity of Some New Substituted Oxa/Thiadiazolylazetidinonyl/Thiazolidinonylcarbazoles.
Authors: Kaur Hemlata , Kumar Sunil , Vishwakarma Pinki , Sharma Monica , Saxena K. K. , Kumar Ashok 
Published: September 2010

AbstractThe biological activity of the newly synthesized compounds (III), (V), and (VII) is evaluated.
ChemInform Abstract: Molecular Sieves as an Efficient and Recyclable Catalyst for Bromolactonization and Bromoacetoxylation Reactions.
Authors: Chen Feng , Jiang Xiaojian , Er Jun Cheng , Yeung Ying‐Yeung 
Published: September 2010

AbstractA simple procedure is developed for the bromolactonization of unsaturated acids and bromoacetoxylation of olefins.
ChemInform Abstract: Nickel/Lewis Acid‐Catalyzed Carbocyanation of Alkynes Using Acetonitrile and Substituted Acetonitriles.
Authors: Yada Akira , Yukawa Tomoya , Idei Hiroaki , Nakao Yoshiaki , Hiyama Tamejiro 
Published: September 2010

AbstractThe scope and limitations of the carbocyanation reaction of a variety of alkynes with nitriles (I) and (V) are reported (40 examples).
ChemInform Abstract: Direct Allylation of α‐Aryl Alcohols with Allyltrimethylsilane Catalyzed by Heterogeneous Tin Ion‐Exchanged Montmorillonite.
Authors: Wang Jiacheng , Masui Yoichi , Onaka Makoto 
Published: September 2010

AbstractVarious secondary aryl and allylic alcohols as well as tertiary alcohol (Ib) are treated with (II) under optimized conditions to give the corresponding allyl compounds in good to excellent yields.
ChemInform Abstract: Metal Acetate/Metal Oxide in Acetic Acid: An Efficient Reagent for the Chemoselective N‐Acetylation of Amines under Green Conditions.
Authors: Brahmachari Goutam , Laskar Sujay , Sarkar Sajal 
Published: September 2010

AbstractA variety of metal acetates and oxides is identified as efficient catalyst for the chemoselective N‐acetylation of amines with acetic acid as acylating agent and solvent.
ChemInform Abstract: Synthesis of Fluorinated Imines by Addition of Fluoroalkyl Radicals to Conjugated Imines.
Authors: Ueda Masafumi , Iwasada Eri , Miyata Okiko , Naito Takeaki 
Published: September 2010

AbstractThe radicals derived from (II) and (V) undergo generally regioselective addition to α,β‐unsaturated imines to give the β‐adducts.With oxime (IX), however, the α‐addition product is formed in low yield.
ChemInform Abstract: Synthesis of Surfactants from Furfural Derived 2[5H]‐Furanone and Fatty Amines.
Authors: Gassama Abdoulaye , Ernenwein Cedric , Hoffmann Norbert 
Published: September 2010

AbstractSix novel twin‐tail amphoteric surfactants (V) and (VII) are readily prepared via a condensation reaction of furanone (I) with fatty amines (II).
ChemInform Abstract: Cyclopropyl Building Blocks for Organic Synthesis. Part 154. Convenient Access to Various 1‐Cyclopropylcyclopropane Derivatives.
Authors: de Meijere Armin , Khlebnikov Alexander F. , Suennemann Hans Wolf , Frank Daniel , Rauch Karsten , Yufit Dmitrii S. 
Published: September 2010

AbstractBicyclopropyl bromide (I) readily undergoes a bromine/lithium exchange, and the resulting lithiated cyclopropane is trapped with various electrophiles providing 1‐substituted bicyclopropyl derivatives.
ChemInform Abstract: An Efficient Procedure for Preparation of 2‐Monoalkyl or 2‐Monoaryl‐3‐ethoxycyclobutanones.
Authors: Matsuo Jun‐ichi , Okuno Ryosuke , Takeuchi Kosuke , Kawano Mizuki , Ishibashi Hiroyuki 
Published: September 2010

AbstractKetenes, generated from the corresponding acid chlorides with base, undergo [2 + 2] cycloaddition with ethyl vinyl ether to give diastereomeric mixtures of title compounds.
ChemInform Abstract: Short Synthesis of Methylenecyclopentenones by Intermolecular Pauson—Khand Reaction of Allyl Thiourea.
Authors: Petrovski Zeljko , Martins Bruno M. R. , Afonso Carlos A. M. 
Published: September 2010

AbstractA novel catalytic Pauson—Khand reaction of thiourea (I) followed by thiourea elimination is presented to give very moderate yields of methylenecyclopentenones in a single step.
ChemInform Abstract: Ligand‐Controlled Selectivity in the Desymmetrization of meso Cyclopenten‐1,4‐diols via Rhodium(I)‐Catalyzed Addition of Arylboronic Acids.
Authors: Menard Frederic , Perez David , Roman Daniela Sustac , Chapman Timothy M. , Lautens Mark 
Published: September 2010

AbstractDesymmetrization of cyclopenten‐1,4‐diols can be achieved via Rh‐catalyzed addition of arylboronic acids to the corresponding dicarbonate (I).
ChemInform Abstract: Palladium‐Catalyzed Allylation of Aryl Halides with Homoallyl Alcohols Bearing a Trisubstituted Double Bond: Application to Chirality Transfer from Hydroxylated Carbon to Benzylic One.
Authors: Wakabayashi Ryota , Fujino Daishi , Hayashi Sayuri , Yorimitsu Hideki , Oshima Koichiro 
Published: September 2010

AbstractThe method allows regio‐ and stereoselective access to allylarenes having two substituents at the 1 and 2 position of the allylic group.
ChemInform Abstract: Room‐Temperature Copper‐Catalyzed Synthesis of Primary Arylamines from Aryl Halides and Aqueous Ammonia.
Authors: Tao Chuanzhou , Liu Weiwei , Lv Aifeng , Sun Mingming , Tian Ying , Wang Qi , Zhao Jing 
Published: September 2010

AbstractDue to the convenience of aqueous NH3 and the inexpensive catalyst system, the method may be of interest for application on an industrial scale.
ChemInform Abstract: Aerobic Oxidative Esterification of Alcohols Catalyzed by Polymer‐Incarcerated Gold Nanoclusters under Ambient Conditions.
Authors: Miyamura Hiroyuki , Yasukawa Tomohiro , Kobayashi Shu 
Published: September 2010

AbstractThe application of polymer‐incarcerated gold nanocluster catalyst for the oxidative esterification of alcohols (I) is reported.
ChemInform Abstract: Glycerol as a Cheap, Safe and Sustainable Solvent for the Catalytic and Regioselective β,β‐Diarylation of Acrylates over Palladium Nanoparticles.
Authors: Delample Mathieu , Villandier Nicolas , Douliez Jean‐Paul , Camy Severine , Condoret Jean‐Stephane , Pouilloux Yannick , Barrault Joel , Jerome Francois 
Published: September 2010

AbstractPalladium nanoparticles stabilized using a cellulose‐derived aminopolysaccharide are successfully applied as catalyst in β,β‐diarylation reactions of acrylates (I) in glycerol.
ChemInform Abstract: A Facile and Efficient One‐Pot Synthesis of Polysubstituted Benzenes in Guanidinium Ionic Liquids.
Authors: Xin Xin , Wang Yan , Xu Wu , Lin Yingjie , Duan Haifeng , Dong Dewen 
Published: September 2010

AbstractA variety of substituted m‐triphenyls (III) is readily prepared by reaction of chalcones (I) with malononitrile (II) in tetramethylguanidinium lactate as solvent.
ChemInform Abstract: A Novel Application of [Cr(en)2]2+ in the Synthesis of 1,2‐Diols from Aromatic Aldehydes.
Authors: Avila‐Sorrosa Alcives , Vega‐Ramirez Leticia , Rodriguez‐Dominguez Rafael , Salgado‐Zamora Hector , Peralta‐Cruz Javier , Reyes‐Arellano Alicia 
Published: September 2010

AbstractA reductive pinacol type arylaldehyde (I) homocoupling process by the [Cr(en)2]2+ complex is described.
ChemInform Abstract: Synthesis of Highly Substituted 1,3‐Dienes, 1,3,5‐Trienes, and 3,6‐Disubstituted Cyclohexenes by the Palladium‐Catalyzed Coupling of Organic Halides, Internal Alkynes or 1,3‐Cyclohexadienes, and Organoboranes.
Authors: Zhang Xiaoxia , Larock Richard C. 
Published: September 2010

AbstractPalladium‐catalyzed coupling of vinylic iodides with internal alkynes and organylboronic acids proceeds with excellent E‐selectivity when E‐vinylic iodides like (I) are used.
ChemInform Abstract: Stereoselective Construction of Highly Functionalized Azetidines via a [2 + 2]‐Cycloaddition.
Authors: Ye Yang , Wang Hua , Fan Renhua 
Published: September 2010

AbstractA one‐pot [2 + 2]‐cycloaddition of 2‐aminomalonates with chalcones via a grind‐promoted, solvent‐free Michael addition and a PhIO/Bu4NI mediated oxidative cyclization is developed.
ChemInform Abstract: 1‐Bromo‐2‐trifluoroacetylcyclobutenes as Novel Building Blocks for the Construction of Trifluoromethyl Substituted Heterocycles. Part 1. Synthesis of 5‐(Trifluoromethyl)‐2(5H)‐furanones Condensed with Substituted Cyclobutenes.
Authors: Koldobskii Andrey B. , Tsvetkov Nikolay P. , Solodova Ekaterina V. , Kalinin Valery N. 
Published: September 2010

AbstractThe lithiation of bromides (II) followed by carboxylation leads to acids (IV), which are readily converted into the desired lactones (V) by the action of trifluoroacetic anhydride.
ChemInform Abstract: Rhodium‐Catalyzed Synthesis of γ‐Butyrolactams and Pyrrolidines via Cycloisomerization of N‐Tethered 1,6‐Enynes.
Authors: Wang Jianping , Xie Xiaomin , Ma Fangfang , Peng Zhiyong , Zhang Lei , Zhang Zhaoguo 
Published: September 2010

AbstractThe title cyclization of the (Z)‐enyne amines and amides (I), (III), and (V) opens a useful access to stereodefined chloroalkylidene pyrrolidine and γ‐butyrolactam derivatives such as (II), (IV), or (VI).
ChemInform Abstract: Enantioselective Construction of Highly Substituted Pyrrolidines by Palladium‐Catalyzed Asymmetric [3 + 2] Cycloaddition of Trimethylenemethane with Ketimines.
Authors: Trost Barry M. , Silverman Steven M. 
Published: September 2010

AbstractA variety of aromatic, aliphatic and cyclic imines is applied in the reaction to afford the target pyrrolidines, including spirocyclic ones, with high dia‐ and excellent enantioselectivities.
ChemInform Abstract: Tuning Electronic and Steric Effects: Highly Enantioselective [4 + 1] Pyrroline Annulation of Sulfur Ylides with α,β‐Unsaturated Imines.
Authors: Lu Liang‐Qiu , Zhang Ji‐Ji , Li Fang , Cheng Ying , An Jing , Chen Jia‐Rong , Xiao Wen‐Jing 
Published: September 2010

AbstractThe reaction of atropisomeric sulfur ylides (I) with unsaturated imines bearing a bulky sulfonyl group at the nitrogen provides pyrroline‐2‐carboxylates with excellent stereocontrol.
ChemInform Abstract: Indium‐Promoted Allylation Reaction of Imino‐Isatins in Aqueous Media: Synthesis of Quaternary 3‐Aminooxindoles.
Authors: Alcaide Benito , Almendros Pedro , Aragoncillo Cristina 
Published: September 2010

AbstractQuaternary 3‐amino‐2‐oxindoles are obtained via allylation and propargylation reactions of imino‐isatins in aqueous media promoted by In or Zn.
ChemInform Abstract: Synthesis and Preliminary Biological Studies of 3‐Substituted Indoles Accessed by a Palladium‐Catalyzed Enantioselective Alkene Difunctionalization Reaction.
Authors: Pathak Tejas P. , Gligorich Keith M. , Welm Bryan E. , Sigman Matthew S. 
Published: September 2010

AbstractSeveral N‐protected indoles are employed as nucleophiles in the difunctionalization reaction of ω‐hydroxyalkenyl‐substituted phenols.
ChemInform Abstract: Nucleophilic Substitution of Oxazino‐/Oxazolino‐/Benzoxazin[3,2‐b]indazoles: An Effective Route to 1H‐Indazolones.
Authors: Donald Michael B. , Conrad Wayne E. , Oakdale James S. , Butler Jeffrey D. , Haddadin Makhluf J. , Kurth Mark J. 
Published: September 2010

AbstractSubstrates (I), (VII), and (XIII) undergo ring‐opening with various nucleophiles to produce 1H‐indazolone products.
ChemInform Abstract: A Novel and an Efficient Catalyst for One‐Pot Synthesis of 2,4,5‐Trisubstituted Imidazoles by Using Microwave Irradiation under Solvent‐Free Conditions.
Authors: Safari Javad , Khalili Shiva Dehghan , Banitaba Sayed Hossein 
Published: September 2010

AbstractAn improved and rapid synthesis of trisubstituted imidazoles (III) (13 examples) by three‐component, one‐pot condensation of benzil with aryl aldehydes and NH4OAc using ammonium heptamolybdate as catalyst is developed.
ChemInform Abstract: The Acid‐Mediated Intramolecular 1,3‐Dipolar Cycloaddition of Derived 2‐Nitro‐1,1‐ethenediamines for the Synthesis of Novel Fused Bicyclic Isoxazoles.
Authors: Page Lee W. , Bailey Matthew , Beswick Paul J. , Frydrych Simon , Gleave Robert J. 
Published: September 2010

AbstractThe five‐membered ring‐fused compound (IIc) gives only poor yield after chromatographic work‐up.
ChemInform Abstract: Intramolecular Cascade C—S Bond Formation: Regioselective Synthesis of Substituted Benzothiazoles.
Authors: Bose D. Subhas , Idress Mohd. 
Published: September 2010

AbstractMicrowave‐assisted synthesis of the target compounds in diphenyl ether (or N,N‐diethylaniline) starts from readily available substrates and proceeds through formation of intermediate thiobenzanilines.
ChemInform Abstract: Synthesis and Dual PPARα/δ Agonist Effects of 1,4‐Disubstituted 1,2,3‐Triazole Analogues of GW 501516.
Authors: Ciocoiu Calin C. , Nikolic Natasa , Nguyen Huyen Hoa , Thoresen G. Hege , Aasen Arne J. , Hansen Trond Vidar 
Published: September 2010

AbstractTriazole derivatives (IV) are prepared and tested for their ability to increase oleic acid oxidation in human myotubes using a high‐throughput multiwell assay.
ChemInform Abstract: Asymmetric Nazarov Reaction Catalyzed by Chiral Tris(oxazoline)/Copper(II).
Authors: Cao Peng , Deng Chao , Zhou You‐Yun , Sun Xiu‐Li , Zheng Jun‐Cheng , Xie Zuowei , Tang Yong 
Published: September 2010

AbstractAlkoxy divinyl β‐ketoesters (I) undergo the title reaction to give cyclopenta[b]pyran derivatives (II) with high regio‐, diastereo‐ and enantioselectivities.
ChemInform Abstract: Synthesis of 14‐Aryl‐14H‐dibenzo[a,j]xanthenes Catalyzed by Acyclic Acidic Ionic Liquids.
Authors: Fang Dong , Liu Zu‐Liang 
Published: September 2010

AbstractSome readily available, acyclic SO3‐functionalized ionic liquids are successfully used as recyclable catalysts for the synthesis of dibenzoxanthenes (III) (10 examples) via condensation of β‐naphthol with benzaldehydes.
ChemInform Abstract: Design and an Efficient Synthesis of New Thiorotenone Derivatives.
Authors: Yao Changsheng , Wang Cuihua , Jiang Bei , Feng Xiaodong , Yu Chenxia , Li Tuanjie , Tu Shujiang 
Published: September 2010

AbstractA range of novel thiopyrano[3,4‐b]pyran‐5‐one derivatives (IV) and (VII) is synthesized by an effective three‐component reaction under solvent‐free and catalyst‐free conditions.
ChemInform Abstract: Inhibitors of the RET Tyrosine Kinase Based on a 2‐(Alkylsulfanyl)‐4‐(3‐thienyl) Nicotinonitrile Scaffold.
Authors: Brandt Wiebke , Mologni Luca , Preu Lutz , Lemcke Thomas , Gambacorti‐Passerini Carlo , Kunick Conrad 
Published: September 2010

AbstractStructurally nicotinonitrile‐based compounds (VII) and (X) are prepared as inhibitors of the cancer‐related tyrosine kinase RET.
ChemInform Abstract: A Novel One‐Pot Synthesis of Substituted Quinolines.
Authors: Sabbaghan Maryam , Yavari Issa , Hossaini Zinatossadat , Souri Sanaz 
Published: September 2010

AbstractIn the presence of ethyl bromopyruvate (III), reaction of isatin (I) and acetylenedicarboxylates (II) results in formation of quinolines (IV) bearing the ethyl ester group in the 4‐position.
ChemInform Abstract: Optimization of 7‐Alkene‐3‐quinolinecarbonitriles as Src Kinase Inhibitors.
Authors: Boschelli Diane H. , Wang Daniel , Wang Yan , Wu Biqi , Honores Erick E. , Sosa Ana Carolina Barrios , Chaudhary Inder , Golas Jennifer , Lucas Judy , Boschelli Frank 
Published: September 2010

AbstractThe preparation of a series of potent Src kinase inhibitors (I) is reported.
ChemInform Abstract: Design and Preparation of Aza‐Analogues of Benzo[c]phenanthridine Framework with Cytotoxic and Antiplasmodial Activities.
Authors: Yapi Ange‐Desire , Desbois Nicolas , Chezal Jean‐Michel , Chavignon Olivier , Teulade Jean‐Claude , Valentin Alexis , Blache Yves 
Published: September 2010

AbstractA regioselective Heck coupling is used as key reaction for the synthesis of novel benzophenanthridine‐like compounds such as (II), (IV) or (V).
ChemInform Abstract: AlCl3‐Induced (Hetero)arylation of Thienopyrimidine Ring: A New Synthesis of 4‐Substituted Thieno[2,3‐d]pyrimidines.
Authors: Kumar K. Shiva , Chamakuri Srinivas , Vishweshwar Peddy , Iqbal Javed , Pal Manojit 
Published: September 2010

Abstractas potential bioactive substances
ChemInform Abstract: New Quinoxaline 1,4‐Di‐N‐oxides: Anticancer and Hypoxia‐Selective Therapeutic Agents.
Authors: Ismail Magda M. F. , Amin Kamelia M. , Noaman Eman , Soliman Dalia H. , Ammar Yousry A. 
Published: September 2010

AbstractA series of novel quinoxaline 1,4‐di‐N‐oxides is prepared and evaluated for antitumor and hypoxia‐selective cytotoxic activities.