bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti-BIRC5 autoantibody serves as a valuable biomarker for diagnosing AFP-negative hepatocellular carcinoma
Authors: Li Qing , Liu Haiyan , Wang Han , Xiong Wenzhuo , Dai Liping , Zhang Xiuzhi , Wang Peng , Ye Hua , Shi Jianxiang , Fang Zhihao , Wang Keyan 
Published: May 2024

Background
Autoantibodies targeting tumor-associated antigens (TAAbs) have emerged as promising biomarkers for early cancer detection. This research aimed to assess the diagnostic capacity of anti-BIRC5 autoantibody in detecting AFP-negative hepatocellular carcinoma (ANHCC).

Methods
This research was carried out in three stages (discovery phase, validation phase, and evaluation phase) and included a total of 744 participants. Firstly, the anti-BIRC5 autoantibody was discovered using protein microarray, exhibiting a higher positive rate in ANHCC samples (ANHCCs) compared to normal control samples (NCs). Secondly, the anti-BIRC5 autoantibody was validated through enzyme-linked immunosorbent assay (ELISA) in 85 ANHCCs and 85 NCs from two clinical centers (Zhengzhou and Nanchang). Lastly, the diagnostic usefulness of the anti-BIRC5 autoantibody for hepatocellular carcinoma (HCC) was evaluated by ELISA in a cohort consisting of an additional 149 AFP-positive hepatocellular carcinoma samples (APHCCs), 95 ANHCCs and 244 NCs. The association of elevated autoantibody to high expression of BIRC5 in HCC was further explored by the database from prognosis, immune infiltration, DNA methylation, and gene mutation level.

Results
In the validation phase, the area under the ROC curve (AUC) of anti-BIRC5 autoantibody to distinguish ANHCCs from NCs in Zhengzhou and Nanchang centers was 0.733 and 0.745, respectively. In the evaluation phase, the AUCs of anti-BIRC5 autoantibody for identifying ANHCCs and HCCs from NCs were 0.738 and 0.726, respectively. Furthermore, when combined with AFP, the AUC for identifying HCCs from NCs increased to 0.914 with a sensitivity of 77.5% and specificity of 91.8%. High expression of BIRC5 gene is not only correlated with poor prognosis of HCCs, but also significantly associated with infiltration of immune cells, DNA methylation, and gene mutation.

Conclusion
The findings suggest that the anti-BIRC5 autoantibody could serve as a potential biomarker for ANHCC, in addition to its supplementary role alongside AFP in the diagnosis of HCC. Next, we can carry out specific verification and explore the function of anti-BIRC5 autoantibody in the occurrence and development of HCC.
Terpyridine‐Functionalized Surfaces: Redox‐Active, Switchable, and Electroactive Nanoarchitecturesgland
Authors: Winter Andreas , Hoeppener Stephanie , Newkome George R. , Schubert Ulrich S. 
Published: July 2011

AbstractTerpyridines represent versatile functional supramolecular building blocks that are easily integrated in numerous devices and can readily modify surfaces. In particular, redox‐active complexes with terpyridine ligands have been attached to surfaces, either by covalent or non‐covalent interactions, and form highly ordered mono‐ or multilayer systems, since electronic and charge transport properties are major topics of interest. Their applications in nanoelectronics are a driving force for understanding and enabling the utilization of the supramolecular properties of terpyridines for surface modification. This area of research has received increasing attention during the last decade leading into the supramacromolecular regime. This Progress Report presents an overview of the state‐of‐the‐art of surface modifications utilizing terpyridine systems and highlights main results, as well as modern trends, in this research area.
Mesenchymal stem cell‐seeded multilayered dense collagen‐silk fibroin hybrid for tissue engineering applications
Authors: Ghezzi Chiara E. , Marelli Benedetto , Muja Naser , Hirota Nobuaki , Martin James G. , Barralet Jake E. , Alessandrino Antonio , Freddi Giuliano , Nazhat Showan N. 
Published: July 2011

AbstractTissue engineering of multilayered constructs that model complex tissues poses a significant challenge for regenerative medicine. In this study, a three‐layered scaffold consisting of an electrospun silk fibroin (SF) mat sandwiched between two dense collagen (DC) layers was designed and characterized. It was hypothesized that the SF layer would endow the DC‐SF‐DC construct with enhanced mechanical properties (e.g., apparent modulus, tensile strength, and toughness), while the surrounding DC layers provide an extracellular matrix‐like environment for mesenchymal stem cell (MSC) growth. MSC‐seeded DC‐SF‐DC hybrids were produced using the plastic compression technique and characterized morphologically, chemically, and mechanically. Moreover, MSC viability was assessed for up to 1 wk in culture. Scaffold analyses confirmed compaction and integration of the meso‐scaled multilayered DC‐SF‐DC hybrid, which was reflected in a significantly higher toughness value when compared to DC and SF alone. MSCs directly incorporated into the DC layers remained viable for up to day 7. The ease of multilayered construct fabrication, enhanced biomechanical properties, along with uniformity of cell distribution confirmed the possibility for the incorporation and segregation of different cell types within distinct layers for the regeneration of complex tissues, such as skin, or central nervous system dura mater.
Dynamics of the Glycosidic Bond: Conformational Space of Lactose
Authors: Erdélyi Máté , d'Auvergne Edward , Navarro‐Vázquez Armando , Leonov Andrei , Griesinger Christian 
Published: July 2011

AbstractThe dynamics of the glycosidic bond of lactose was studied by a paramagnetic tagging‐based NMR technique, which allowed the collection of an unusually large series of NMR data for a single compound. By the use of distance‐ and orientation‐dependent residual dipolar couplings and pseudocontact shifts, the simultaneous fitting of the probabilities of computed conformations and the orientation of the magnetic susceptibility tensor of a series of lanthanide complexes of lactose show that its glycosidic bond samples syn/syn, anti/syn and syn/anti ϕ/ψ regions of the conformational space in water. The analysis indicates a higher reliability of pseudocontact shift data as compared to residual dipolar couplings with the presently available weakly orienting paramagnetic tagging technique. The method presented herein allows for an improved understanding of the dynamic behaviour of oligosaccharides.
Comparison of Extraction Procedures for Assessing Soil Metal Bioavailability of to Wheat Grains
Authors: Bakircioglu Dilek , Kurtulus Yasemin Bakircioglu , İbar Hilmi 
Published: July 2011

AbstractAgricultural soils have been analyzed to elucidate whether the trace metal distribution changes in relation to agricultural activities and to predict environmental risk. In addition to the extractability of Cu, Mn, Ni, Pb, and Zn in soils was compared by single extraction (hydrochloric acid (HCl), ethylenediaminetetraacetic acid (EDTA), diethylenetriaminepentaacetic acid (DTPA), calcium chloride (CaCl2), water (H2O)), and sequential extraction procedures. The modified Community Bureau of Reference (BCR) sequential extraction procedure (three‐step) used to extraction of metals in soil samples. The extraction capacity of the analyzed metals was found by using single extraction procedures in the order: HCl > EDTA > DTPA > CaCl2 > H2O. A single correlation analysis was used to investigate the relationship between extractable metal concentrations in soil solutions and metal accumulation in wheat grains. Simple correlation analyses indicated that the extractable Pb and Ni of soils by HCl, EDTA, and DTPA single extraction procedures were significantly correlated with the metal contents of wheat grains. For CaCl2, H2O, and BCR extraction procedures there was a relatively poor correlation between the extractable Cu, Mn, Ni, Pb, and Zn of soils and metal contents of wheat grains.
Evaluating electrochemical behaviour of recrystallized titanium alloys in Ringer's solution
Authors: Mareci D. , Chelariu R. , Sutiman D. , Gordin D. M. , Gloriant T. 
Published: July 2011

AbstractBy anodic potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) techniques, the effect of recrystallization on the corrosion and electrochemical behaviour of Ti12Mo and Ti12Mo5Ta alloys was studied. Aerated Ringer's solution was employed as electrolyte solution at 37 °C. The pH was 6.9 and adjusted to 2.5 simulating the disease state. The results show excellent corrosion resistance for recrystallized Ti12Mo and Ti12Mo5Ta alloys, corroborated by high values of polarization resistance and low values of passive current density. Recrystallized structure rendered the Ti12Mo and Ti12Mo5Ta alloys extremely corrosion resistant.
Multi‐dimensional mass spectrometry‐based shotgun lipidomics and novel strategies for lipidomic analyses
Authors: Han Xianlin , Yang Kui , Gross Richard W. 
Published: July 2011

AbstractSince our last comprehensive review on multi‐dimensional mass spectrometry‐based shotgun lipidomics (Mass Spectrom. Rev. 24 (2005), 367), many new developments in the field of lipidomics have occurred. These developments include new strategies and refinements for shotgun lipidomic approaches that use direct infusion, including novel fragmentation strategies, identification of multiple new informative dimensions for mass spectrometric interrogation, and the development of new bioinformatic approaches for enhanced identification and quantitation of the individual molecular constituents that comprise each cell's lipidome. Concurrently, advances in liquid chromatography‐based platforms and novel strategies for quantitative matrix‐assisted laser desorption/ionization mass spectrometry for lipidomic analyses have been developed. Through the synergistic use of this repertoire of new mass spectrometric approaches, the power and scope of lipidomics has been greatly expanded to accelerate progress toward the comprehensive understanding of the pleiotropic roles of lipids in biological systems. © 2011 Wiley Periodicals, Inc., Mass Spec Rev 31:134–178, 2012
Effect of different grain sizes and textures on the corrosion behaviour of aluminum alloy AA6082
Authors: Händel M. , Nickel D. , Lampke T. 
Published: July 2011

AbstractThe fabrication and processing of aluminum alloys can result in the formation of different grain sizes and textures within the material. The effects of these differences on the corrosion behaviour of the commercially available alloy AA6082 have been investigated. The results of the macro‐ and microelectrochemical investigations have been compared with each other and with the resulting corrosion appearance. The observed corrosion damage is not always consistent with the measured corrosion and pitting potential. In the finer‐grained part, with a strongly preferred orientation of (002) planes parallel to the sample surface, less corrosion damage could be observed than in the coarser‐grained part. However, microelectrochemical measurements show a slightly lower pitting potential in the finer‐grained part, so that pitting is likely to start earlier in this area.
Influence of ultrasonic vibration assistance on the surface integrity in turning of the aluminium alloy AA2017
Authors: Schubert A. , Nestler A. , Pinternagel S. , Zeidler H. 
Published: July 2011

AbstractThe surface integrity of components considerably influences the reliability of technical systems. According to the application of the components, their surfaces have to meet different demands. Cutting processes with geometrically defined cutting edge are often used as final machining processes. They offer the opportunity to influence the surface integrity by means of the process kinematics, process parameters and tool geometry. In the case of realising a predefined surface integrity, for example the generation of microstructures, these machining processes reach their limits very fast. For this reason, the influence of ultrasonic vibration assistance in cutting is investigated with focus on achieved surface integrity. Different vibration directions of the tool are examined. This paper investigates the effect of ultrasonic vibration assistance on the surface integrity, obtained in turning processes. Several possibilities for generating predefined surface microstructures are identified. In turning with ultrasonic vibration assistance in the cutting direction, the mean cutting force is markedly reduced in comparison to conventional machining. The examinations show that turning with ultrasonic vibration assistance enables a specific setting of the surface integrity within a wide range. It is expected that the results can be applied to other, also difficult to machine materials.
Postural instability, frontotemporal dementia, and ophthalmoplegia: Clinicopathological case
Authors: Cardoso Francisco , Hodges John , Evans Andrew H. , Revesz Tamas , Williams David R. 
Published: July 2011

AbstractA 56‐year‐old man presented with gait disturbance, personality change, and behavioral disturbances. He subsequently developed falls, postural instability, and axial rigidity. The cognitive problems progressed and he developed aphasia and later eye movement abnormalities. He died after 9 years of disease. Experts discuss the syndromal diagnosis and predict the underlying pathology. The pathological diagnosis is given and clinical learning points are considered. © 2011 Movement Disorder Society
Atmospheric Plasma Deposition Process: A Versatile Tool for the Design of Tunable Siloxanes‐Based Plasma Polymer Films
Authors: Petersen Julien , Bechara Rony , Bardon Julien , Fouquet Thierry , Ziarelli Fabio , Daheron Laurence , Ball Vincent , Toniazzo Valérie , Michel Marc , Dinia Aziz , Ruch David 
Published: July 2011

AbstractThis paper aims at describing the synthesis of plasma polymer films by means of atmospheric filamentary plasma dielectric barrier discharge. This work highlights the fact that molecular structures of siloxane based plasma films can be tuned according to the so‐called Yasuda's parameter, which corresponds to the W/F ratios (W = power discharge; F = Monomer flow rate). Indeed, we showed that the plasma films exhibit a polydimethylsiloxane (PDMS) structure when W/F was low (i.e. when low plasma energy is applied), whereas SiOx structures were rather obtained when W/F is high (i.e. high plasma energy). These results were validated thanks to a wide set of analytical tools allowing to identify two domains where molecular structures of the plasma films swiftly progress from PDMS to SiOx according to W/F ratios.magnified image
Outward Migration from Large Cities: Are Older Migrants in Nairobi ‘Returning’?
Authors: Falkingham Jane , Chepngeno‐Langat Gloria , Evandrou Maria 
Published: July 2011

ABSTRACTCircular and return migrations between rural and urban areas in sub‐Saharan Africa have persisted over time, driven by a combination of socio‐cultural, economic, and structural forces. Much of the literature on migration in Africa focuses on labour migration. However, old age also marks a stage in the life course often associated with migration. This paper examined the determinants of out‐migration among older people living in the slums of Nairobi. The paper used a prospective population study of 2,270 older people, followed up over a 3‐year period. The annual rate of out‐migration was 4%. Cox proportional hazard analysis was used to model the effect of ties to place and to socio‐economic capital on propensity to out‐migrate. The presence of adult children outside the city was a significant pull factor for both men and women. The propensity to out‐migrate decreased with length of residence in the slum. Attachment to the slum through participation in voluntary communal activities was also negatively associated with out‐migration, particularly for men. The poorest older people were more likely to leave the city, highlighting the effect of deprivation in triggering return migration. Looking at future migration intentions, only one in five older people reported that they intend to relocate from the slums, highlighting that, in the future, there will be a growing number of people ageing ‘in situ’ in poor urban areas. This has implications for policy makers concerned with the provision of services to vulnerable older people who may be unable to engage in livelihood strategies as health deteriorates with age. Copyright © 2011 John Wiley & Sons, Ltd.
Processing of Ceramic Preforms for TRIP‐Matrix‐Composites
Authors: Hasterok Manuel , Wenzel Claudia , Aneziris Christos G. , Ballaschk Uta , Berek Harry 
Published: July 2011

AbstractMetal matrix composites have been produced by conventional infiltration of ceramic preforms. The magnesia partially stabilised ceramic foams were prepared by replication method. In terms of the present paper the second process step that comprises the cold spraying of the impregnated foam is optimised. The spray coating is essential in ceramic foam production. It eliminates defects that are caused due to the squeezing process and assists to reach the critical wall thickness for acceptable mechanical properties. For this reasons the rheology of the spraying slurry and the adjustment of the spraying system have been investigated. Quality of the spray coatings was evaluated by computer tomography. The obtained ceramic foams were infiltrated by a TRIP‐steel (TRansformation Induced Plasticity) to create composite materials with improved mechanical properties. Phase composition of the composite material has been analysed using Electron Backscatter Diffraction Method (EBSD).
Non‐additive effects of leaf litter and insect frass mixture on decomposition processes
Authors: Kagata Hideki , Ohgushi Takayuki 
Published: July 2011

AbstractAlthough there is a growing body of evidence that herbivorous insects have a significant impact on decomposition and soil nutrient dynamics through frass excretion, how mixtures of leaf litter and insect frass influence such ecosystem processes remains poorly understood. We examined the effects of mixing of leaf litter and insect frass on decomposition and soil nutrient availability, using a study system consisting of a willow, Salix gilgiana Seemen, and a herbivorous insect, Parasa consocia Walker. The chemical characteristics of insect frass differed from those of leaf litter. In particular, frass had a 42‐fold higher level of ammonium–nitrogen (NH4+–N) than litter. Incubation experiments showed that the frass was decomposed and immobilized with respect to N more rapidly than the litter. Furthermore, litter and frass mixtures showed non‐additive enhancement of decomposition and reduction of NH4+–N, depending on the litter–frass mixing ratio. These indicate that, while insect frass generally accelerated decomposition, the effect of frass on soil nutrient availability was dependent largely on the relative amounts of litter and frass.
Firmware lower-level discrimination and compression applied to streaming x-ray photon correlation spectroscopy area-detector data
Authors: Madden T. , Fernandez P. , Jemian P. , Narayanan S. , Sandy A. R. , Sikorski M. , Sprung M. , Weizeorick J. 
Published: July 2011

We present a data acquisition system to perform on-the-fly background subtraction and lower-level discrimination compression of streaming x-ray photon correlation spectroscopy data from a fast charge-coupled device (CCD) area detector. The system is built using a commercial frame grabber with an on-board field-programmable gate array. The system is capable of continuously processing at least 60 CCD frames per second each consisting of 1024 × 1024 16-bit pixels with ≲ 15 000 photon hits per frame at a maximum compression factor of ≈95%.
Separating invariants for the basic 𝔾ₐ-actions
Authors: Elmer Jonathan , Kohls Martin 
Published: July 2011

We explicitly construct a finite set of separating invariants for the basicGa{\mathbb G}_{a}-actions. These are the finite dimensional indecomposable rational linear representations of the additive groupGa{\mathbb G}_{a}of a field of characteristic zero, and their invariants are the kernel of the Weitzenböck derivationDn=x0∂∂x1+…+xn−1∂∂xnD_{n}=x_{0}\frac {\partial }{\partial {x_{1}}}+\ldots + x_{n-1}\frac {\partial }{\partial {x_{n}}}.
The distribution of alcohol consumption and the prevention paradox in Brazil
Authors: Caetano Raul , Mills Britain , Pinsky Ilana , Zaleski Marcos , Laranjeira Ronaldo 
Published: July 2011

ABSTRACTAims To examine the proportion of self‐reported alcohol consumed by different gender and age groups in Brazil over the past year, and to examine whether the ‘prevention paradox’ applies to Brazilian data on alcohol‐related problems.Design A multi‐stage cluster sample, representative of the Brazilian household population.Setting This study was conducted in Brazil between November 2005 and April 2006.Participants Respondents were aged ≥ 14 years (n =  3007).Measurements Measures included past year estimates of (i) number of standard drinks, (ii) frequency of binge drinking, and (iii) alcohol‐related problems.Findings The survey response rate was 66.4%. The top 2.5% of the drinkers by volume consume 14.9%, the top 5% consume 27.4% and the top 10% consume 44.2% of all alcohol consumed in Brazil. Men consume 77.8% of the total alcohol, and 18–29‐year‐olds consume 40.3%. Individuals below risky drinking guidelines for weekly volumetric intake account for 49–50% of all problem drinkers and 45–47% of all problem types reported. Individuals who do not binge or who binge infrequently (1–3 times/year) account for 50–51% of all problem drinkers and 45–46% of all reported problem types. Most binge drinkers are low‐volume drinkers.Conclusions Consistent with the prevention paradox literature, most drinking problems in Brazil are associated with low or moderate drinking. Binge drinking accounts more clearly for the distribution of alcohol problems than total volume consumed.
Changes occurring during the parboiling of upland rice and in the maceration water at different temperatures and soaking times
Authors: da Fonseca Flávia Araújo , Soares Júnior Manoel Soares , Caliari Márcio , Bassinello Priscila Zaczuk , da Costa Eifert Eduardo , Garcia Diva Mendonça 
Published: July 2011

SummaryThe objective of this work was to investigate the influence of temperature and soaking time on the quality of grains from two upland rice cultivars. Response surface methodology and a central compound rotational design were used. The data obtained for the cultivars BRS Primavera and BRS Sertaneja varied, respectively, between 27.7–55.0% and 26.0–51.7% for the Husk‐Splitting Index; between 0.8–5.0% and 0.0–4.0% for the incidence of ‘banana’ grains; between 0.0–2.0% and 0.0–1.2% for non‐gelatinised grains; and between 0.2–0.7% and 0.2–0.8% for soluble solids in the maceration water. Because BRS Primavera grains had a narrower shape, they absorbed the water faster and consequently presented a greater amount of physical defects, although the losses to the water were smaller than BRS Sertaneja.