bluuebunny/crossref_metadata_2025_split huggingface dataset:
971-P: "Take a Chance on Me"—A Trial of Automated Insulin Delivery in Those Who Historically Declined Pump Therapy
Authors: IBRAHIM CHRISTINE 
Published: June 2024

Introduction & Objective: In Ontario, Canada there are strict guidelines for those with type 1 diabetes (T1D) to qualify for insulin pump therapy. This often excludes those with significant glycemic variability, mixed adherence and difficulties with carbohydrate counting. However, with automated insulin delivery (AID), there are less managerial steps, making insulin-pump management easier, with improved results given algorithmic insulin modifications. Given this, this historically ignored population, would be most ideal for AID access.
Methods: This qualitative and quantitative trial identified four patients with historically difficult to manage diabetes and placed them on a nine-week trial of Dexcom G6 sensor, and six weeks on Tandem Control-IQ. They were given a pre- and post-survey and followed every 2 weeks to evaluate time in range (TIR), hypoglycemia, and assess quality of life.
Results: There were N=4 patients, 2 male, duration of diabetes 2-20 years, HbA1c (9.5-11%), pre-trial TIR 20-50%, pre-trial hypoglycemia &lt;1%. Post-trial, A1c (7.3-8.6%), end-trial TIR 46-67%, and post-trial hypoglycemia &lt;2%. Post-survey, comments included “Having the ability to feel more ‘normal’ having access to my sugars all the time without having to finger prick or scan⋯” “I didn’t have to think too much other than carb counting⋯” “Being able to have insulin all the time without giving a needle is great.”
Conclusion: This study demonstrates that the advancement in AID should enable a policy change to allow ubiquitous usage to those with T1D for best standard of care.

Disclosure
C. Ibrahim: None.
985-P: Association of CGM Data Interpretation by Health Care Providers with Glycemic Control for Patients with Type 2 Diabetes
Authors: HANNAH KATIA , NEMLEKAR POORVA , NORMAN GREGORY J. 
Published: June 2024

This study examined the association between change in A1c and CGM data interpretation by health care providers (HCPs) among people with T2D using a personal CGM, stratified by insulin therapy. US administrative claims data for this retrospective analysis were from Optum’s deidentified Clinformatics® Database. Commercially insured people with T2D using any personal CGM with evidence of CGM data interpretation (billing code 95251) between 1/1/2020 and 12/31/2021 (index = earliest observed billing claim) were identified. Those with evidence of professional CGM use (billing code 95250), prior CGM data interpretation, and pregnancy were excluded. Cohorts were stratified by insulin and non-insulin therapy. A1c change was assessed 12 months pre- and post-index date. A total of 2,099 individuals (mean age=54 (SD=10.1) years, 55% male) met inclusion criteria. Across stratified cohorts, two groups were defined as ‘CGM + data interpretation’ and ‘CGM without data interpretation’. Independent of insulin therapy, use of data interpretation by HCPs was associated with a greater decrease in A1c among people with T2D using a personal CGM (Table). These results suggest a significant benefit from incorporation of CGM data interpretation by HCPs. Integration of CGM data interpretation may facilitate collaborative care plan development between patient and HCP.

Disclosure
K. Hannah: Employee; Dexcom, Inc. P. Nemlekar: Employee; Dexcom, Inc. G.J. Norman: Employee; Dexcom, Inc.
987-P: iCan CGM System—Performance Evaluation of a New CGM System with an Innovative Sensor Technology
Authors: JI LINONG , FLACKE FRANK , GAO FEI , YU YUANYUAN , ZHENG JIYUN , GAO AO , FEI JIANGFENG 
Published: June 2024

Introduction and Objectives: The iCan CGM system, developed by Sinocare Meditech Inc. is equipped with an innovative sensor technology. Data presented here are from a multicenter study which assessed accuracy of the iCan CGM system; conducted in China according to international standards and which resulted in regulatory submission. The iCan CGM system received regulatory clearance 2023 in People’s Republic of China and EU for a wear time of 15 days.
Methods: The study had a single arm, prospective multicenter design and evaluated the iCan CGM system in one of 2 subgroups. There were 60 patients with T1D and T2D aged ≥18yrs enrolled into this subgroup and at days 2, 7-9 and 15 the performance of the device was assessed by comparison to YSI readings. The data were analyzed according to generally accepted procedures.
Results: For per protocol set (PPS) the surveillance error grid analysis shows 100% of the data pairs in the none to slightly lower/higher degree of risk zones (none 94.12% (95%CI: 86.96% - 100%), slightly lower 5.76% (95%CI: 0% - 12.86%), slightly higher 0.12% (95%CI: 0% - 1.15%). Also, the Clarke error grid confirms this high correlation with the reference method with 99.22% (95%CI: 98.67% - 99.58%) in Zones A+B. The full analysis set (FAS) analysis shows a MARD 8.88% (95%CI: 7.98% - 9.77%) which is similar the previously reported MARD of 8.71% (95%CI: 7.86 - 9.55%) from the PPS analysis, and stays below a MARD of 8% for the complete wear life. The average wear life was estimated to 14.76 (1.26) days. There were no SAEs, devices related AEs and no skin related AEs reported during the study.
Conclusion: The iCan CGM system, becoming available on the worldwide markets, demonstrated in a multicenter trial overall accuracy performance on par with established devices, high EGA correlation as well as single digit MARD throughout 15 days, in combination with an outstanding sensor wear life. (NCT0599575)

Disclosure
L. Ji: None. F. Flacke: Consultant; BOYDSense SAS, Sinocare Meditech Inc., embecta. F. Gao: Employee; Sinocare Inc. Y. Yu: Employee; Sinocare Inc. J. Zheng: Employee; Sinocare Inc. A. Gao: Employee; Sinocare Inc. J. Fei: Employee; Sinocare Inc.
991-P: Use of a Mobile Diabetes Self-Management Application Is Associated with Increased Blood Glucose Monitoring Frequency and Improved Glycemic Control
Authors: ULMER BRIAN , RUCH BERNHARD , REPETTO ENRICO 
Published: June 2024

Introduction and Objectives: While recommended blood glucose monitoring (BGM) frequency varies by therapy and individual circumstances, many people with type 2 diabetes (T2D) may not follow suggested monitoring guidelines. Given recent advancements in blood glucose monitoring technology, we studied the impact of connecting a BG meter to a mobile diabetes self-management app (mySugr®) on testing frequency and glycemic control.
Methods: We performed a retrospective analysis of 103,400 mySugr app users in the United States with self-reported T2D who were enrolled between January, 2018 and November, 2023 and calculated the change in BG testing frequency and mean BG per 30-day period in the 180 days following glucometer connection to mySugr to the 30-day period prior to connection. We also analyzed the impact of BG logging frequency on the change in glycemic control.
Results: Following enrollment in the app, users increased the frequency of BG testing from a baseline of 19.87 logs (95% CI 19.61-20.15) in the 30-day period prior to mySugr connection to 52.38 BG logs (52.02-52.74) in days 0-30 following connection and 32.57 logs (32.27-32.86) at 150-180 days. Mean BG was 175.87 mg/dL (175.43-176.36) at baseline and 143.99 mg/dL (143.62 - 144.38) at 180 days following connection to mySugr. Users who logged greater than 30 logs between 150 and 180 days after registration had a greater reduction of mean BG (-20.44 mg/dL [-19.70 - -21.22]) than those with 30 or fewer logs (-18.35 mg/dL [-17.78 - -18.95]).
Conclusion: Following glucometer connection to the mySugr app, users recorded significantly more BG logs up to 180 days following connection. Use of the mySugr app was associated with a significant reduction in mean BG, and users who recorded &gt; 30 logs/30 days achieved a greater reduction in mean BG vs. those who recorded &lt;= 30 logs/30 days.

Disclosure
B. Ulmer: Employee; Roche Diabetes Care. B. Ruch: Employee; Roche Diabetes Care. E. Repetto: Employee; Roche Diabetes Care.
998-P: Real-World Evidence for Computerized Insulin Dose Adjustment Algorithms (CIDAAs) in the Effective Use of Continuous Glucose Monitoring (CGM) by Primary Care Clinicians (PCCs)
Authors: DAVIDSON MAYER B. , DAVIDSON JOSH 
Published: June 2024

Introduction & Objective: PCCs are challenged using insulin because of time constraints and experience. Mellitus Health has developed FDA-cleared CIDDAs that enabled PCCs to effectively lower A1C levels by 1.5-2.0% over 3-6 months in poorly controlled, insulin-requiring patients who provided remote glucose readings to HIPAA approved cloud-based CDAAs that analyzed them and sent dose change recommendations to PCCs. Inconvenience and discomfort limit glucose fingerstick tests, barriers which CGM overcome. This study examined the ability of these CIDAAs to help PCCs effectively utilize CGM in similar patients.
Methods: A clinical pharmacist used a Free Style Libre Pro in 23 patients and an NP used a Dexcom reader in 13 patients, both in real world situations. Since A1C levels were not scheduled at specific times, the outcomes were changes in average glucose (AG) levels and calculated eA1Cs between the 1st and last reports sent to the PCC who could accept or modify the dose adjustment recommendations. The new doses served as the basis for the next report.
Results: A mean of 159 reports were issued over a mean of 113 days. Initial and final insulin regimens were basal alone, 15 and 12, basal/bolus, 20 and 23, and 1 short-acting alone in both. Baseline AGs (mg/dL ± SD) fell from 230 ± 68 to 196 ± 56 and eA1Cs (% ± SD) from 9.6 ± 2.4 to 8.4 ± 1.9 (P &lt;0.001 by paired t tests). The PCCs accepted 56% of the recommended changes. Percents of glucose values &lt;70 mg/dL were &lt;2.0% and not significantly different between 1st and last reports signifying the safety of these CIDAAs. The total doses of insulin increased by 43%.
Conclusions: If a higher % of recommendations had been accepted, there may have been greater decreases. CIDAAs can facilitate and educate PCCs in the effective use of CGM.

Disclosure
M.B. Davidson: Other Relationship; Mellitus Health. J. Davidson: Employee; Mellitus Health.
Adakah Hubungan antara Usia dan Gangguan Indera Perasa pada Pasien COVID-19?
Authors: Khalimatus Suanti  , Fransiska Fransiska , Astrid Pratidina Susilo  
Published: June 2024

Abstract—COVID-19 (coronavirus disease 2019) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical symptoms of COVID-19 patients vary widely, for example the olfactory and taste disorder. Several studies reported the prevalence of taste disorder of 71% to 88.8% in COVID-19 patient. This research aimed to determine the association between age and taste disorders during the spread of the Delta variant of COVID-19. A cross sectional study conducted on 42 subjects. The data was analyzed using Independent T-test. Statistical analyzed showed that 27 out of 42 subjects experienced taste disorders. The mean age of COVID-19 patients with taste disorders was 50 years (SD 12.83). In the independent T-test, a p-value of 0.613 was obtained (p>0.05), which means that there was no association between age and taste disorders. Taste disorders are caused by hyposalivation which begins to occur at the age of 65 and over. This study concluded no significant correlation between age and taste disorders in COVID-19 patients.
Keywords: COVID-19 patients, age, taste disorders

Abstrak—COVID-19 (coronavirus disease 2019) adalah penyakit pernapasan yang disebabkan oleh Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Gejala klinis pasien COVID-19 sangat bervariasi, di antaranya gangguan indera penghidu dan perasa. Beberapa penelitian melaporkan prevalensi gangguan indera perasa sebesar 71% hingga 88,8% pada pasien COVID-19. Penelitian ini bertujuan untuk mengetahui hubungan rerata usia dengan gangguan indera perasa selama penyebaran COVID-19 varian Delta. Studi cross sectional dilakukan pada 42 subjek penelitian. Teknik pengambilan data adalah total sampling, yaitu pada pasien yang rawat inap karena COVID-19. Data dianalisis dengan menggunakan Uji T-tidak berpasangan. Analisis statistik menunjukkan bahwa 27 dari 42 pasien mengalami gangguan indera perasa. Usia rata-rata pasien COVID-19 dengan gangguan indera perasa adalah 50 tahun (SD 12,83). Pada uji T-tidak berpasangan didapatkan nilai p sebesar 0,613 (p>0,05), yang berarti tidak ada hubungan antara usia dengan gangguan indera perasa.
Kata kunci: pasien COVID-19, usia, gangguan perasa
Pengaruh Inflasi Dan Suku Bunga Terhadap Return Saham Dengan Profitabilitas Sebagai Variabel Moderasi Pada Perusahaan Indeks Lq 45 Di BEI Tahun 2019-2021
Authors: Ardiansyah Japlani  , Febiyanto  , Paramita Citra Abadi  
Published: June 2024

The development of a free business world as it is today, it is no stranger to the public to make investments with the aim of obtaining greater returns than investing in the banking sector. Investment is now an open secret where all investors can easily access and channel their funds to companies they consider promising and capable of providing more value to what they have invested. the research used by researchers is descriptive with a quantitative approach which aims to find out whether inflation affects stock returns, to find out whether interest rates affect stock returns, to find out whether the profitability variable can moderate the relationship of inflation to stock returns, to find out whether the profitability variable can moderate the relationship between interest rates and stock returns. The sample used is a company that is active and consistent in the LQ 45 index during the 2019-2021 period. As well as data regarding the research variables to be examined are fully available in the company's financial reports published during the 2019-2021 period. Data analysis techniques using descriptive analysis, classic assumption test, hypothesis testing and moderating variable test. The result of this research is that inflation has a significant influence on stock returns at LQ 45 companies in 2019-2021. Interest rates have a significant influence on stock returns in LQ 45 companies in 2010-2021. profitability affects the relationship of inflation to stock returns in LQ 45 companies in 2019-2021. profitability affects the relationship between interest rates and stock returns in LQ 45 companies in 2019-2021.
Прогнозування часу та періодів очікування страхових випадків
Authors: Іллічева Л. М. , Авдєєва Т. В. 
Published: June 2024

У роботі розглядаються закономірності визначення середнього часу до появи першого
страхового випадку, першого із деякої кількості страхових випадків; закономірності
розподілу «рекордних» по тривалості періодів між страховими випадками.
“Amor é dar o que não se tem”
Authors: Fascina Diego Luiz Miiller 
Published: June 2024

Este artigo discute a temática amorosa presente em algumas composições de Cazuza, a partir do materialismo lacaniano do filósofo esloveno Slavoj Žižek. De acordo com essa teoria, é possível compreender que, na obra de Cazuza, as variações do amor se assemelham ao caráter plástico do objeto a, um dos conceitos centrais da psicanálise lacaniana. Em uma leitura panorâmica, as letras abordam vertentes de um mesmo amor, o qual possui sua estrutura fundada no vazio da causa do desejo: na produção cazuziana o amor é visto como ficção, também pode estar à deriva do desejo que está no Outro e, por fim, é dado como impossível.
Palavras-chave: Cazuza; temática amorosa; materialismo lacaniano; Slavoj Žižek.
Esclerose múltipla: revisão dos principais tratamentos da doença
Authors: Alves Beatriz , Angeloni Renata , Azzalis Ligia , Pereira Edimar , Perazzo Fábio , Rosa Paulo César , Feder David , Junqueira Virginia , Fonseca Fernando 
Published: June 2024

Introdução: A esclerose múltipla é uma doença de causa desconhecida e sem cura, caracterizada por múltiplos focos de desmielização ao longo do sistema nervoso central. Os sintomas podem ser confundidos com os de outras doenças do sistema nervoso central, o que dificulta seu diagnóstico, e danos provocados culminam com inúmeros déficits neurológicos. Os tratamentos oferecidos atualmente buscam reduzir a atividade inflamatória e os surtos causados pela doença, permitindo uma melhora na qualidade de vida do paciente e uma redução da incapacidade adquirida ao longo dos anos. Objetivos: O objetivo desta revisão foi realizar um levantamento dos tratamentos oferecidos aos pacientes, relatando as principais finalidades, principais resultados, efeitos colaterais mais comuns e aceitação ao tratamento. Materiais e Métodos: Foram utilizados artigos publicados, sites das principais associações de paciente com esclerose, visitas às associações, informações obtidas com profissionais da saúde da área e com indústrias farmacêuticas. Resultados: Não existe um tratamento específico para a doença: este varia com a evolução e com o estado do paciente. Conclusão: O médico deverá acompanhar o tratamento indicado, adequar a dose sempre que necessário e estar atento aos efeitos colaterais e à eficácia do medicamento, tendo como foco a qualidade de vida do paciente.
O impacto da Diabetes Melito e da hipertensão arterial para a saúde pública
Authors: Machado Luis Eduardo , Campos Renata 
Published: June 2024

As doenças crônicas não transmissíveis (DCNTS) são atualmente a principal causa de mortalidade no mundo. Os dados são alarmante principalmente devido a morbidade que estas doenças ocasionam. O objetivo foi avaliar o impacto de duas DCNTS, a DM e HAS, na saúde pública. Foi aplicado um questionário semiestruturado em duas unidades de saúde de um município do Planalto Norte Catarinense para avaliar as ações em saúde para as DCNTSs. Na farmácia central deste município foram coletados informações sobre os medicamentos dispensados e gastos com cada doença. Dados sobre a mortalidade em 10 anos foram obtidos no município estudado e também no Estado de Santa Catarina. Os dados sobre a mortalidade são crescente tanto para ao Estado quanto para o município estudado. A dispensação de medicamentos para DM e HAS são onerosos ao sistema público. Conclui-se que a DM e HAS são onerosas aos cofres públicos, a prevalência de HAS predomina no município estudado e as ações de educação em saúde são executadas, contudo, sem um acompanhamento efetivo sobre o impacto destas ações no controle da DM e HAS.
Avaliação da toxicidade celular do herbicida glifosato em Astyanax spp.
Authors: Silva Maico Roberto Luckmann Rodrigues da 
Published: June 2024

Os agrotóxicos são agentes químicos amplamente utilizados na agricultura no controle de ervas invasoras. Dentre os agrotóxicos, o organofosforado Roundup® é um dos herbicidas mais usados no Brasil. Seu princípio ativo é o glifosato, geralmente comercializado na forma de sal isopropilamônio, cujas propriedades químicas possibilitam que se solubilize facilmente nos ambientes aquáticos. Este agente tóxico atinge os corpos d'água através do lençol freático por meio da lixiviação e infiltração da água das chuvas, da irrigação ou da percolação no solo. Concentrações subletais podem provocar alterações moleculares e celulares que afetarão a morfologia, fisiologia e bioquímica dos tecidos. Neste estudo propôs-se utilizar como modelo experimental o peixe nativo Astyanax spp., com o objetivo principal de analisar a frequência de micronúcleo nos peixes que foram expostos por 72 horas à concentração de 65 µg/L de glifosato (concentração regulamentada pela Resolução do CONAMA nº357 de 2005 para água de rios no Brasil). O teste de micronúcleo investiga as células eritropoiéticas, para avaliar dano cromossômico in vivo. Os peixes foram divididos em dois grupos (grupo controle e grupo tratado), em água de aquário declorada com monitoramento da temperatura e aeração constante. Os peixes foram aclimatados por 3 dias e após foram expostos ao glifosato diluído na água do próprio aquário. Para a análise do micronúcleo foi extraído sangue das brânquias, n = 6 peixes por aquário, e utilizado a técnica de esfregaço e coloração com giemsa de acordo com protocolo para análise de micronúcleo písceo. Assim, considerando a contaminação dos ambientes aquáticos por agrotóxicos e diante da precariedade de estudos sobre o assunto, torna-se imprescindível à realização de estudos direcionados a avaliação da toxicidade celular do glifosato em organismos aquáticos. Após a confecção das lâminas para identificação dos micronúcleos foram contadas aproximadamente 1500 células/lâmina com total de 3000 células por peixe. Houve diferença estatística (p?0,05) para a taxa de micronúcleo dos peixes do grupo controle (sem a presença de glifosato) e o grupo tratado com 65 ug/L de glifosato. Valores de temperatura e pH entre os aquários foram registrados, mas sem diferenças significantes, descartando a ideia de variação micronúcleo písceo entre os dois grupos por estes fatores. Os sutis efeitos nocivos do glifosato sobre o DNA dos eritrócitos de Astianax spp., demonstradas aqui são uma preocupação séria para a biologia de peixes e deve ser levado em conta. Estes resultados contribuem para a compreensão da toxicidade do glifosato para os organismos não-alvo e o seu potencial efeito genotóxico.
Change in the productivity of stands of the spruce (Picea abies L.) mountain Carpathian forests district over a 70-year period
Authors: Myklush Stepan , Myklush Yuriy , Debryniuk Iurii , Prystupa Roman 
Published: June 2024

Abstract
The state and comparison of stands of the spruce mountain Carpathian forests district, which involves a significant portion of the forest fund of the State Enterprise ‘Rakhiv Experimental Forestry’, are analysed based on materials of forest management. The analysis examines changes in the area covered by forest vegetation, the formation peculiarities of the main inventory indicators of forest stands and their evolution over an almost 70-year period of forest management activities in the region. The aim of this study is to analyse the forest management materials of the spruce mountain Carpathian forests, focusing on the forest vegetation area and the main management indices of tree stands over a 70-year period. It highlights the intensive economic impact on stands, evidenced by a decrease in average relative completeness. Sustainable forest management necessitates a comprehensive understanding of the ecosystem, encompassing biological, ecological and socioeconomic aspects. Long-term regional studies and modern forest management approaches are crucial for informed decision-making. In addition, involving local communities, stakeholders and experts in decision-making ensures socially acceptable, economically viable and environmentally sound management practices. It is suggested that mitigating the negative impacts of climate change on natural ecosystems involves forming native stands of rational structure and composition in the mountainous Carpathians, recognising the potential benefits of integrating conifers into beech stands and vice versa.