bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correspondence between the alcohol‐P3 event‐related potential and alcohol reward phenotypes among young adults
Authors: Acuff Samuel F. , Cofresí Roberto U. , Varner Austin , Dennhardt Ashley A. , Sable Jeffrey J. , Bartholow Bruce D. , MacKillop James , Murphy James G. 
Published: June 2024

AbstractBackgroundBehavioral economic theory suggests that the value of alcohol depends upon elements of the choice context, such that increasing constraints on alternatives (e.g., price) or increasing the benefits of alcohol (e.g., social context) may result in greater likelihood of heavy drinking. The P3 event‐related potential elicited by alcohol‐related cues, a proposed marker of incentive salience, may be an electrophysiological parallel for behavioral economic alcohol demand. However, these indices have not been connected in prior research, and studies typically do not disaggregate social influences in the context of alcohol cue reactivity.MethodThe current study recruited heavy drinking young adults (N = 81) who completed measures of alcohol use and alcohol demand, in addition to a 2 (social/nonsocial) × 2 (alcohol/nonalcohol) visual oddball task to elicit the P3.ResultsIn multilevel models controlling for demographic characteristics, P3 reactivity was greater to alcohol (p < 0.001) and social (p < 0.001) cues than to nonalcohol and nonsocial cues, but without a significant interaction. Higher alcohol consumption (p = 0.02) and lower elasticity of demand (p = 0.01) were associated with greater P3 response to alcohol than nonalcohol cues.ConclusionsThe results highlight a brain‐behavior connection that may be an important marker for alcohol reward across units of analysis and may be sensitive to changes in the economic choice contexts that influence the likelihood of alcohol use.
Responses of Gross's stinkfish, Callionymus grossi (Ogilby 1910) to perceived threats
Authors: Ebner Brendan C. 
Published: June 2024

AbstractPredator avoidance is critical to fish survival and yet multiple types of predator response are rarely recorded at the level of individuals let alone studied in detail. Behaviour of an individual adult male dragonet, Gross's stinkfish Callionymus grossi (Ogilby 1910) (Family Callionymidae) was observed over the course of four consecutive daily snorkelling sessions on high tides in the Maroochy River estuary, Queensland, Australia. On two occasions, the dragonet buried in the sand in the presence of a great barracuda, Sphyraena barracuda, whereas, smaller benthic predators or competitors and the observer sometimes provoked dorsal fin raising and fleeing responses of the dragonet. The dragonet, therefore, demonstrates multiple responses to potential predators and competitors seemingly depending on the likely severity of interaction. Further research of dragonet fishes is recommended to disentangle the functionality of fin display in this group, with the anti‐predator function of fin displays and honest signalling of chemical defence a promising aspect for investigation.
Barriers and enablers to accessing perinatal health services for rural Australian women: A qualitative exploration of rural health care providers perspectives
Authors: Faulks Fiona , Edvardsson Kristina , Shafiei Touran 
Published: June 2024

AbstractObjectiveTo identify perceived barriers and enablers for rural women in accessing perinatal care within their own community from the perspective of perinatal health care providers.DesignA qualitative descriptive study design utilising reflexive thematic analysis, using the socioecological framework to organise and articulate findings.SettingVictoria, Australia.ParticipantsSemi‐structured interviews were conducted with nine perinatal health care providers who provide care to pregnant women or new mothers in rural communities. Participants were recruited across Victoria in 2023.ResultsProviders reported multi‐level barriers and enablers that exist for rural women in accessing perinatal care within their communities. Barriers included women's personal circumstances, challenging professional relationships, inequitable service provision, ineffective collaboration between services and clinicians and government funding models and policies. Enablers included strength and resilience of rural women, social capital within rural communities, flexible care delivery and innovative practice, rural culture and continuity of care models.ConclusionRural perinatal health care providers perceived that rural women face multiple barriers that are created or sustained by complex interpersonal, organisational, community and policy factors that are intrinsic to rural health care delivery. Several addressable factors were identified that create unnecessary barriers for rural women in engaging with perinatal care. These included education regarding health systems, rights and expectations, equitable distribution of perinatal services, improved interprofessional relationships and collaborative approaches to care and equity‐based funding models for perinatal services regardless of geographical location.
Early blast clearance during sequential conditioning prior to allogeneic stem cell transplantation in patients with acute myeloid leukaemia
Authors: Ronnacker Julian , Urbahn Marc‐Andre , Reicherts Christian , Kolloch Lina , Berning Philipp , Sandmann Sarah , Eßeling Eva , Call Simon , Floeth Matthias , Marx Julia , Albring Jörn , Mikesch Jan‐Henrik , Schliemann Christoph , Lenz Georg , Stelljes Matthias 
Published: June 2024

SummaryFor patients with relapsed or refractory AML, sequential conditioning prior to allogeneic stem cell transplantation (alloSCT) is an established and potentially curative treatment option. Early response to treatment during conditioning indicates chemotherapy‐responsive disease and may have prognostic value. We retrospectively evaluated blast clearance on day 5 after melphalan, administered 11 days prior to alloSCT as part of a sequential conditioning in 176 patients with active AML. Overall survival (OS) was 52% (95% confidence interval [CI] 45%–60%), and relapse‐free survival (RFS) was 47% (95% CI 40%–55%) at 3 years. Patients who achieved early blast clearance did not show a significant improvement in OS and RFS (OS, hazard ratio [HR] HR 0.75, p 0.19; RFS, HR 0.71, p 0.09, respectively), but had a significantly lower non‐relapse mortality rate (HR 0.46, p 0.017). HLA‐mismatched donor, older age, adverse genetic risk and higher comorbidity scores were associated with inferior survival outcomes. A high initial blast count was only associated with inferior prognosis in patients receiving chemotherapy‐only compared to total body irradiation containing conditioning therapy. These results indicate that for patients transplanted with active AML, sensitivity to chemotherapy might be of less importance, compared to other disease‐ and transplant‐related factors.
SERPINA11 related novel serpinopathy – A perinatal lethal disorder
Authors: Aggarwal Shagun , Vineeth Venugopal Satidevi , Padwal Shrutika S. , Bhat Sameer Ahmed , Singh Arpita , Kulkarni Aditya , Patil Mallikarjun , Tallapaka Karthik , Pasumarthi Divya , Venkatapuram Vijayasree , Thotakura Pragna Lakshmi , Dalal Ashwin , Bhandari Rashna 
Published: June 2024

AbstractSERPINA11 is a hitherto poorly characterised gene belonging to Clade A of the SERPIN superfamily, with unknown expression pattern and functional significance. We report a perinatal lethal phenotype in two foetuses from the same family associated with a biallelic loss of function variant in SERPINA11, and provide functional evidence to support its candidature as a Mendelian disorder. The SERPINA11 variant‐associated foetal phenotype is characterised by gross and histopathological features of extracellular matrix disruption. Western blot and immunofluorescence analyses revealed SERPINA11 expression in multiple mouse tissues, with pronounced expression in the bronchiolar epithelium. We observed a significant decrease in SERPINA11 immunofluorescence in the affected foetal lung compared with a healthy gestation‐matched foetus. Protein expression data from HEK293T cell lines following site‐directed mutagenesis support the loss of function nature of the variant. Transcriptome analysis from the affected foetal liver indicated the possibility of reduced SERPINA11 transcript abundance. This novel serpinopathy appears to be a consequence of the loss of inhibition of serine proteases involved in extracellular matrix remodelling, revealing SERPINA11 as a protease inhibitor critical for embryonic development.
Diagnosing contact dermatitis using machine learning: A review
Authors: McMullen Eric , Grewal Rajan , Storm Kyle , Maazi Mahan , Butt Abu Bakar , Gupta Raghav , Maibach Howard 
Published: June 2024

AbstractBackgroundMachine learning (ML) offers an opportunity in contact dermatitis (CD) research, where with full clinical picture, may support diagnosis and patch test accuracy.ObjectiveThis review aims to summarise the existing literature on how ML can be applied to CD in its entirety.MethodsEmbase, Medline, IEEE Xplore, and ACM Digital Library were searched from inception to February 7, 2024, for primary literature reporting on ML models in CD.Results7834 articles were identified in the search, with 110 moving to full‐text review, and six articles included. Two used ML to identify key biomarkers to help distinguish between allergic contact dermatitis (ACD) and irritant contact dermatitis (ICD), three used image data to distinguish between ACD and ICD, and one used clinical and demographical data to predict the risk of positive patch tests. All studies used supervision in their ML model training with a total of 49 704 patients across all data sets. There was sparse reporting of the accuracy of these models.ConclusionsAlthough the available research is still limited, there is evidence to suggest that ML has potential to support diagnostic outcomes in a clinical setting. Further research on the use of ML in clinical practice is recommended.
Antwerp's Royal Museum of Fine Arts
Authors: Doering Zahava D. 
Published: June 2024

AbstractThe Royal Museum of Fine Arts in Antwerp, Belgium, reopened after an 11‐year renovation. In addition to completely cleaning the exterior façade of the neoclassical building, a new, modern wing was built inside former internal courtyards—a glossy, white cube with very high ceilings and a dramatic 100+ step flight of stairs. The historical part of the museum was also fully renovated to its original grandeur. The collection was reinstalled, and the overall interpretive strategy focused on making the art approachable to a multigenerational and multicultural visitorship: Eschewing chronology, paintings are grouped by themes, texts are user‐friendly and encourage interactive experiences, and special activities are available for children. Short videos are also available in some galleries that provide context, explain specific art techniques, or contain games. A wide range of experiences is available to museum users, somewhat consistent with an approach proposed by the Smithsonian Institution's IPOP framework. The reviewer found the reinstallation and related user experiences a relevant, people‐oriented model for 21st century art museums.
Epilepsy professionals' views on sudden unexpected death in epilepsy counselling: A tale of two countries
Authors: Watkins Lance , Henning Oliver , Bassett Paul , Ashby Samantha , Tromans Samuel , Shankar Rohit 
Published: June 2024

AbstractBackground and purposeSudden unexpected death in epilepsy (SUDEP) is a leading cause of epilepsy mortality. All international guidance strongly advocates for clinicians working with people with epilepsy (PWE) to discuss SUDEP. Clinician views working with PWE in the UK and Norway on SUDEP counselling are compared.MethodsA cross‐sectional online mixed methodology survey of 17 Likert and free‐text response questions using validated themes was circulated via International League against Epilepsy/Epilepsy Specialist Nurses Association in the UK and International League against Epilepsy/Epilepsinet in Norway using a non‐discriminatory exponential snowballing technique leading to non‐probability sampling. Quantitative data were analysed using descriptive statistics and Mann–Whitney, Kruskal–Wallis, chi‐squared and Fisher's exact tests. Significance was accepted at p < 0.05. Thematic analysis was conducted on free‐text responses.ResultsOf 309 (UK 197, Norway 112) responses, UK clinicians were more likely to have experienced an SUDEP (p < 0.001), put greater importance on SUDEP communication (p < 0.001), discuss SUDEP with all PWE particularly new patients (p < 0.001), have access and refer to bereavement support (p < 0.001) and were less likely to never discuss SUDEP (p < 0.001). Significant differences existed between both countries’ neurologists and nurses in SUDEP counselling with UK clinicians generally being more supportive. UK responders were more likely to be able to identify bereavement support (p < 0.001). Thematic analysis highlighted four shared themes and two specific to Norwegians.DiscussionDespite all international guidelines stating the need/importance to discuss SUDEP with all PWE there remain hesitation, avoidance and subjectivity in clinicians having SUDEP‐related conversations, more so in Norway than the UK. Training and education are required to improve communication, engagement and decision making.
Screening ultrasonographic findings of Thoroughbred weanling horses show agreement with concurrent radiographic examination and with subsequent yearling sales radiographs
Authors: Hoey Seamus , McAllister Hester , Laverty Sheila , O'Sullivan Jeremiah , Toomey William , Connolly Susan , Skelly Cliona 
Published: June 2024

SummaryBackgroundA screening ultrasonographic examination of yearling Thoroughbred horses has been described which can be performed on farm, as an adjunct to pre‐sale yearling radiography.ObjectivesTo compare ultrasonographic and radiographic findings in young Thoroughbred horses in the detection of osteochondrosis.Study designDescriptive and comparative study using ultrasonography and radiography.MethodsForty‐four horses with a mean age of 10 months underwent an ultrasonographic screening protocol of joint groups including the bilateral stifle, tarsal, carpal and metacarpophalangeal/metatarsophalangeal joints. Concurrent standardised radiographic projections of all the joints were also undertaken. A cohort of 26 of these horses had a second set of radiographs taken for yearling sales approximately 6 months later. Two reviewers reviewed all images for presence or absence of osteochondrosis lesions. Comparison of the ultrasonographic and radiographic findings was undertaken using Gwet's AC1 and the Landis and Kock scale.ResultsThe principal observer identified 48 ultrasonographic lesions and 15 radiographic lesions on the initial examination. Overall, there was agreement in screening for osteochondrosis using ultrasonographic and radiographic lesions, however, with varying levels of agreement for different joint groups. Agreement for individual joint groups was almost perfect for the carpal (0.98) and metatarsophalangeal joints (0.81), substantial for the stifle joints (0.67), moderate for the metacarpophalangeal joint (0.59) with only fair agreement of the tarsal joints (0.30). Six osteochondral lesions were recorded on the second set of radiographs. There was overall substantial agreement between the ultrasonographic findings and the second set of radiographs. A second observer reviewed the ultrasonographic and radiographic images. There was moderate interobserver agreement comparing ultrasonographic images, and almost perfect interobserver agreement comparing radiographic images.Main limitationsSmall number of horses who presented for yearling sale radiography for comparison. One ultrasonographer acquired all images, and two observers reviewed the images.ConclusionUltrasonographic screening of yearling horses with a relatively low number of lesions showed agreement with concurrent and yearling sale radiographs.
John Henry Newman: Shaping the Philosopher
Authors: McHugh Paul James 
Published: June 2024

AbstractThe difficulties in placing Newman in a philosophical school or in putting some sort of shape on Newman the philosopher stem in part from Newman's (understandable) near failure to guide the reader as to his overt philosophical method. On the other hand, in the many discussions and controversies that occupied Newman throughout his life—whether conducted through letters or more formal writings—there is gathering witness to a consistent philosophical way in Newman. This paper seeks to put some shape on Newman the philosopher by two principal methods. First, by considering some inaccurate or wholly misleading philosophical labels which have been attached to Newman both in his day and in contemporary times. These help, as it were, to shape Newman the philosopher from without. Second, by examining those elements of his writing that have a philosophical cast, and teasing out hints and clues to Newman the philosopher. The paper argues that while Newman can most certainly be thought of as a philosopher, his subtle philosophical way situates him only problematically in any particular philosophical school, though there can in his work be traced connections to particular philosophical programmes, such as, for example, British empiricism.
Gel‐forming properties of Bambara groundnut globulin and protein subfractions: structural and rheological characterisation
Authors: Alabi Opeyemi O. , Amonsou Eric O. 
Published: June 2024

SummaryThe gel‐forming ability of the pulse proteins influences the formation of food products with desirable texture, structure, and stability. In this study, Bambara globulin was fractionated into legumin and vicilin for structural and physicochemical analyses, and heat‐induced gel rheological characterisation. Bambara globulin showed major vicilin (7S, Mw: 120 kDa) and minor legumin (11S, Mw: 410 kDa) components by size exclusion chromatography and gel electrophoresis analyses. Legumin had the lowest amount of all the charged amino acids. One basic subunit (22 kDa) was identified in the legumin fraction with predominant helical structures. The sol–gel transition temperatures increased in the order of globulin (40 °C) < legumin (50 °C) < vicilin (80 °C). The G′ and G″ of globulin showed relatively low dependency on heating time beyond the gel point compared to legumin and vicilin subfractions, suggesting a more rapid establishment of its gel network during gelation. Vicilin gel consisted of a microporous structure with a small lath sheet‐like structure compared to others. Bambara vicilin could be a prospective ingredient in the development of new products with defined textural characteristics.
Intergenerational adverse childhood experiences and adolescent migration aspirations in Nicaragua
Authors: Alcaraz Melissa , Schmeer Kammi K. , Weitzman Abigail 
Published: June 2024

AbstractAdolescents' aspirations are strong predictors of their future outcomes, including later migration experiences. Adversity also shapes aspirations for and decisions about the future. Adverse childhood experiences (ACEs) are measures of early exposure to adversity and may be associated with migration aspirations, though this relationship is understudied. Given high rates of gender‐based violence, single‐headed households and economic insecurity, Nicaragua is an important context to study this relationship. Drawing on Nicaragua Health and Stress Study data, we estimate multinomial logistic regressions to examine the association between adolescents' and mothers' ACEs and adolescent migration aspirations. We find that mothers' ACEs, but not adolescents' ACEs, are positively associated with adolescent migration aspirations. We also find that girls are more likely than boys to aspire to migrate. Results highlight how family and gender work together to shape young people's migration goals, with important implications for migration flows within and outside Central America.
High spatial variability in a species‐rich assemblage of diadromous fishes in Hong Kong, southern China
Authors: Chan Jeffery C. F. , Liew Jia Huan , Dudgeon David 
Published: June 2024

AbstractChina has experienced substantial coastal reclamation and damming of rivers. These changes have the potential to impact migrations of diadromous fishes between the sea and fresh waters, but the composition of these fishes and the impacts of barriers to their movement in China have received little attention. We inventoried the species composition and distribution of diadromous fishes, and the impacts of barriers on them, in the Hong Kong Special Administrative Region (HKSAR), southern China. Fish assemblages were surveyed using hand‐nets, supplemented by cast‐netting and single‐pass snorkel surveys, in 24 small coastal streams across three regions. Surveys were undertaken on multiple occasions during the wet and dry seasons to account for the monsoonal tropical climate. Twenty‐eight diadromous fishes were collected, mostly gobies, amounting to over half (53%) of the total richness of primary freshwater fishes; four additional species are known from literature records. Diadromous richness was 48% greater during the wet season, when all species were encountered. Richness varied substantially among streams, from a maximum of 17 (2 streams that were diversity hot spots) to none (3 streams). The most widespread diadromous fish was Glossogobius giuris (71% frequency of occurrence), followed by Mugil cephalus (58% occurrence) and Eleotris oxycephala (50% occurrence). The remaining 25 diadromous fishes occurred in fewer than half of the streams; 12 species were confined to a single stream and may be locally threatened. There were conspicuous spatial differences in diadromous assemblages across HKSAR, despite its limited extent (1114 km2), the proximity of the surveyed streams, and the broad geographic distribution of most species. Regional species assemblages were influenced by localized habitat characteristics, with a noticeable distinction between areas with and without large, fast‐flowing, and highly oxygenated streams. The presence of in‐stream barriers (weirs: 0.3–8.7 m high) did not affect spatial patterns in species assemblages, although, on average, diadromous richness was lower in weir‐obstructed streams (4.0 vs. 6.9 species in unobstructed streams). In total, 18 species were confined to unobstructed streams or sections below weirs, whereas the remaining 10 species were recorded both above and below weirs. Only the mottled eel (Anguilla marmorata) and a goby (Stiphodon multisquamus) were able to ascend weirs over 2 m. Although at least 400 m of the lower course of each stream was sampled, diadromous fishes were confined to the first 300 m in 12 of the 13 weir‐obstructed streams. Remarkably, the tally of 32 diadromous species in HKSAR exceeds the 19 known from mainland China, highlighting the need for further research on composition and conservation status of diadromous fishes.