bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case of Ovarian Serous Adenocarcinoma Suggestive of Transformation to an AFP‐Producing Tumor during Chemotherapy
Authors: Kataoka Akio , Nishida Takashi , Sugiyama Toru , Yakushiji Michiaki 
Published: August 2010

AbstractOvarian serous adenocarcinoma with AFP production is very rare. A case involving a 66‐year‐old woman with an elevated serum AFP level without detectable hepatic involvement. AFP‐positive cells were seen in the tumor at the second surgery. Fifty‐seven percent of serum AFP from the patient bound Con A, whereas 43% did not. Similarly, 54% of the tumor fluid also bound Con A. These suggest that the serum AFP was similar to that of gastrointestinal tumors and yolk‐sac tumors.
Posthemorrhagic Hydrocephalus in a Fetus with Severe Tachycardia
Authors: Matsui Hiroshi , Chaki Osamu , Yanagisawa Takashi , Nakayama Masaki , Hirahara Fumiki , Takahashi Tsuneo , Taga Michiyoshi , Minaguchi Hiroshi , Kawataki Motoyoshi 
Published: August 2010

AbstractAlthough posthemorrhagic hydrocephalus has been observed in premature infants, few cases of its intrauterine occurrence in fetuses have been reported. We report a case of posthemorrhagic hydrocephalus in a fetus with severe tachycardia. This case indicates that its possible occurrence should be considered in a case of a preterm fetus with distress.
Magnetic Resonance Imaging of Autosomal Recessive Polycystic Kidney Disease in utero
Authors: Nishi Takenori 
Published: August 2010

AbstractObjective: To assess the efficacy of ultrasonography (USG) and magnetic resonance imaging (MRI) in diagnosing a particular urologic disease, autosomal recessive polycystic kidney disease (ARPKD).Subject: A patient with a case of ARPKD, as diagnosed by USG and MRI.Result: USG revealed features typical of ARPKD; the kidneys were enlarged and echogenic, with a loss of normal renal architecture. MRI revealed anatomical features similar to those demonstrated by USG. Furthermore, MRI showed clearer delineation and tissue specificity of the affected kidneys.Conclusion: USG and MRI were useful in diagnosing ARPKD. MRI can serve as an adjunctive method for diagnosing certain fetal anomalies.
Risk Factors for Wolfe's Dysplasia of Mammograms in Postmenopausal Turkish Women
Authors: Uslu Turhan , Topuz Atakan , Erçal Tijen , Acar Berrins 
Published: August 2010

AbstractObjective: The aim was to ascertain whether menstrual, reproductive and hormonal risk factors for breast cancer are present in women with dysplastic mammographic patterns and to investigate possible trends towards breast cancer.Method: This prospective case‐control study was designed in a university hospital. Thirty‐two turkish postmenopausal women were evaluated for the associations between obesity, parity, age, age at menarche, age at menopause, total lactation period and dysplasic mammographic patterns.Results: We found an increasing trend of dysplasia with increasing age at menarche. This association contradicts the well established one for breast cancer. The effects of parity and total lactation period on dysplasia were similar. Although nulliparity had some protective effects on dysplasia, relative risk (RR) increased to some extent with an increase in parity and lactation period. Later menopause and older age were associated with an increase risk of dysplasia, whereas an apparent protection was given by greater body mass index.Conclusion: Onset of the menopause increases the risk of dysplasia and the estrogenic milieu may have some role in the initiation and progression of dysplasia.
Prediction of Histopathologic Features and Proliferative Activity of Uterine Leiomyoma by Magnetic Resonance Imaging Prior to GnRH Analogue Therapy: Correlation between T2‐Weighted Images and Effect of GnRH Analogue
Authors: Oguchi Osamu , Mori Atsushi , Kobayashi Yaeko , Horiuchi Akiko , Nikaido Toshio , Fujii Shingo 
Published: August 2010

AbstractTo predict the histological features and proliferative activity of leiomyomas and to evaluate the effect of GnRH analogues (GnRHa) by MR images, the correlation between MR images and histopathologic findings was studied on 137 leiomyomatous nodules from 79 patients. The correlation among cellularity, proliferative activity and MR images was studied on sections of 42 leiomyomatous, nodules stained with hematoxylin‐eosin and immunohistochemistry for proliferating cell nuclear antigen. The utility of MR imaging in assessing response to therapy with a GnRHa (buserelin 900 μg/day, intranasal for 16 weeks) was studied on 62 leiomyomatous nodules from 29 patients.On T2‐weighted MR images, we encountered five major images. According to the increase of signal intensity relative to that of the myometrium and/or the endometrium, the images were classified as Type 1, Type 2, Type 3, Type 4, and Type 5. Histopathologically, the majority of Type 1, Type 2 and Type 3 images had features of typical leiomyoma. Almost all cellular leiomyomas and bizarre leiomyomas had Type 4 images. Variable degenerative features were observed in the nodules with Type 5 images. According to the increase of signal intensity, leiomyomas had a tendency to show a high degree of both cellularity and proliferative activity. Moreover, the reduction rate of leiomyomatous nodules after GnRHa therapy correlated with the tumor signal intensity on T2‐weighted images before therapy. The reduction rate was the lowest in Type 1 images (20.9%) and the highest in Type 4 images (50.7%).These results suggest that increased the signal intensity on T2‐weighted MR images correlates with the cellularity and proliferative activity of leiomyomas, and with tumor response to GnRHa treatment. MR imaging enables quantitative monitoring of GnRHa therapy in patients with leiomyomatous nodules, and allows us to predict the histopathology, cellularity, proliferative activity, and shrinkage rate of nodules before GnRHa treatment.
External Cephalic Version from 34 Weeks under Tocolysis: Factors Influencing Success
Authors: Foote Andrew J. 
Published: August 2010

AbstractExternal cephalic version (ECV) was performed on 72 patients from 34 weeks of gestation under tocolysis, with ultrasound control and cardiotocograph surveillance. Successful ECV was associated with multiparity, decreased lower segment caesarean section (LSCS) rate, and earlier discharge home. ECV was successful in 51.4% of patients overall, with the success rate being 35% in primigravidas and 71.4% in multiparas (p<0.005). The LSCS rate was reduced from 91.4% to 0% (p < 0.0001) on comparing the unsuccessful and the successful ECV groups, while breech presentation was reduced from 94.3% to 0% (p < 0.0001). There were no significant fetal complications.
Toxoplasmosis as a Cause of Repeated Abortion
Authors: Sahwi Samir Y. , Zaki Magda S. , Haiba Nassr Y. , Elsaid Omar K. , Anwar Medhat Y. , AbdRabbo Salah A. 
Published: August 2010

AbstractThe extent to which toxoplasmosis causes habitual abortion is still controversial. The present study was carried out on 100 cases of repeated abortions, and 40 multiparous pregnant women at 20th week gestation as a control.Tests for the presence of toxoplasma IgG and/or IgM antibodies were done for both groups. It was found that 19% of the selected cases, and 7.5% of the control were seropositive for IgM. The difference was statistically insignificant, therefore acute toxoplasmosis, most probably, is not related to habitual abortions, whereas 37% of the selected cases and only 10% of the control group were seropositive at high dilution for IgG antibody, this statistical significant difference indicates that chronic toxoplasmosis, most probably is a significant cause of repeated abortion. Also it has been found that toxoplasmosis has a significant relation to abortion at first trimester.
Association of Multiple Human Papillomavirus Types with Vulvar Neoplasias
Authors: Nagano Hiroaki , Yoshikawa Hiroyuki , Kawana Takashi , Yokota Harushige , Taketani Yuji , Igarashi Hiroko , Yoshikura Hiroshi , Iwamoto Aikichi 
Published: August 2010

AbstractObjective: The purpose of this study was to clarify the association of multiple genital human papillomavirus (HPV) types with vulvar neoplasias.Methods: We examined vulvar neoplasias by the polymerase chain reaction (PCR) method, which can detect almost all genital HPV types sensitively (L1‐PCR).Results: Eight HPV types (types 6, 11, 16, 18, 52, 53, 56, and 68) were detected in 52 of 53 (98.1%) vulvar condylomas; 2 HPV types (types 16 and 18) were detected in all 6 Grade‐3 vulvar intraepithelial neoplasias; and 5 HPV types (types 6, 16, 18, 51, and 56) were detected in 8 of 11 (72.7%) invasive vulvar carcinomas. Detection of HPV types 52, 53, 56, and 68 in vulvar condylomas and detection of HPV types 51 and 56 in vulvar carcinomas are the first examples ever reported.Conclusion: This study suggests that more HPV types are associated with the generation of vulvar neoplasias than was thought to be the case up to now.
A Case of Vulvar Schwannoma
Authors: Yamashita Yoshiki , Yamada Takashi , Ueki Ken , Ueki Minoru , Sugimoto Osamu 
Published: August 2010

AbstractSchwannoma is generally a solitary, nodular, benign tumor of a peripheral nerve sheath, and it rarely affects the external female genitalia. Its most‐common locations are the head, neck, upper and lower extremities, posterior mediastinum, and retroperitoneum. We treated a 29‐year‐old woman with a vulvar schwannoma. A tumor of 2.5 cm in diameter was resected for treatment and biopsy. It was a capsulate tumor with a smooth surface, and was elastic in consistency. A histological examination revealed a swirling pattern with some palisading of spindle‐shaped cells in H.E. stains. Immunohistochemical studies showed the tumor to be positive for S‐100 protein and negative for desmin. As a result, the mass proved to be schwannoma originating from the vulva.
Gonadoblastoma in Patient with Turner's Syndrome
Authors: Lo Keith W. K. , Lam S. K. , Cheung T. H. , Wong S. P. , Chang Allan , Chow John H. S. 
Published: August 2010

AbstractA 15‐year‐old phenotypic female referred for the investigation of primary ammenorrhea, was found to have a 45 XO karyotype and an ovarian cyst. She demonstrated some of the features of Turner's syndrome, as well as virilization. On laparotomy, she was found to have bilateral gonadoblastomas. She was treated with total abdominal hysterectomy and bilateral salpingo‐oophorectomy. Subsequently, repeated chromosomal analysis detected the presence of Y chromosomes, which was confirmed by the use of polymerase chain reaction (PCR). The difficulties encountered in searching for the Y chromosome in patients with gonadoblastoma are discussed. Prophylactic gonadectomy is suggested in those cases associated with atypical features.
Ovarian Mucinous Cystadenocarcinoma with Sarcoma‐Like Mural Nodules
Authors: Kataoka Akio , Nishida Takashi , Ueyama Takako , Okina Hideto , Yakushiji Michiaki 
Published: August 2010

AbstractWe present a rare case of a 31‐year‐old woman with a mucinous ovarian tumor with sarcoma‐like mural nodules. The epithelial elements consisted of a mixture of benign, borderline‐malignant, and mucinous adenocarcinoma; the sarcoma‐like mural nodules consisted of pleomorphic and epulis‐like cells. The lesion was resected for an ovarian tumor. In an immunohistochemical study, these cells stained for lysozyme and vimentin. The patient received 2 courses of cisplatin (100 mg/m2). There was no evidence of disease at a second‐look laparotomy after 1 year, and none upon examination 6 years after the initial operation. The mural nodules might be of non‐epithelial origin. The prognosis of patients with this rare lesion appears favorable, according to this and previous reports.
Two Cases of Twisted Fetal Ovarian Cysts
Authors: Yokoyama Yoshihito , Kagiya Akifumi , Ozaki Takashi , Ogasawara Tomoka , Saito Yoshiharu , Sugai Michihiro 
Published: August 2010

AbstractTwo twisted fetal ovarian cysts were detected antenatally by routine ultrasonographic examination. Serial changes of twisted ovarian cysts can be monitored by ultrasonic observation. If signs of torsion appear, obstetricians should consider prompt delivery in order to preserve the patient's fertility.
Case Report: Torsion of a Gravid Horn of a Didelphic Uterus
Authors: Achanna Siva , Monga Deepika , Hassan M. Suhaimi 
Published: August 2010

AbstractAcute abdominal pain during pregnancy presents a dilemma as signs and symptoms are often modified. Abdominal massage by traditional birth attendants (TBAs') during early labour is a common practice in the rural population, as it is perceived to give a soothening effect to the labouring mother. Many instances of abruptio placentae were reported in the past by this procedure, and in this case, the clinical picture presented as an abruptio placenta. Malpresentation and failure to progress were the indications for caesarean section despite the fetal demise. Severe post partum haemorrhage and failure to contract despite massive oxytocics resulted in the hysterectomy of the gravid horn, leaving the other horn intact.
Preinduction Cervical Ripening with Intravaginal Prostaglandin E1 Methyl Analogue Misoprostol: A Randomized Controlled Trial
Authors: Srisomboon Jatupol , Tongsong Theera , Tosiri Visit 
Published: August 2010

AbstractObjective: To evaluate the efficacy of intravaginal prostaglandin E1 methyl analogue misoprostol in cervical ripening in patients with unfavorable cervix (Bishop score < 4) requiring labor induction.Method: A randomized controlled clinical trial of 62 women in the third trimester with various indications for induction of labor were randomly allocated to receive either 100 μg misoprostol inserted vaginally (32) or placebo similarly applied (30). Transvaginal sonography was performed to measure the cervical length before and 12 hrs after insertion.Results: The mean change in cervical length and Bishop score was significantly greater in the misoprostol group (24 mm and score 8) compared with in the placebo group (2.2 mm and score 1) (p = 0.001). All but one patients receiving misoprostol went into labor while only one in the placebo group did so. The interval from insertion to vaginal delivery was significantly shorter in the misoprostol group (12.0 vs 25.5 hrs, p < 0.001). Delivery occurred within 24 hrs in 75% and 30% of patients in the misoprostol and placebo groups respectively. Uterine tachysystole occurred more frequently in the misoprostol group (38%) than in the placebo group (0%) (p < 0.001). All could be rapidly reversed by tocolytics without apparent untoward intrapartum effects. No significant differences were noted in the 2 groups in terms of perinatal outcomes and mode of delivery.Conclusion: Intravaginal misoprostol is an effective, cheap and safe method for cervical ripening. The higher frequency of uterine tachysystole in the misoprostol group did not increase the risk of adverse intrapartum and neonatal outcomes.
Bone Mineral Density of the Spine Using Dual Energy X‐Ray Absorptiometry in Patients with Non‐Insulin‐Dependent Diabetes Mellitus
Authors: Kwon Dong‐Jin , Kim Jim‐Hong , Chung Ki‐Wook , Kim Jang‐Heub , Lee Jin‐Woo , Kim Soo‐Pyung , Lee Hun‐Young 
Published: August 2010

AbstractTo evaluate the influence of non‐insulin‐dependent diabetes mellitus (NIDDM) on bone mineral density (BMD), we measured BMD in 185 female patients with NIDDM using dual energy X‐ray absorptiometry (DEXA). BMD was measured in lumbar vertebrae (L2–4). BMD is slightly higher in the diabetic patients compared with control subjects and bone loss related to menopause starts before the onset of menopause. The BMD of postmenopausal women showed a definite decrease with aging and there was abrupt bone loss after 55 years of age (p < 0.05). In relation to the duration of diabetes, the decrease of BMD for 15 years was 10.0%. BMD was negatively correlated with age, years since menopause (YSM), and disease duration (r = ‐ 0.584, r = ‐ 0.470, r = ‐0.186). These results suggest that age, YSM, and the duration of disease appear to be the risk factors for decreased BMD in the diabetic patients.
Clinical Evaluation of Plasma Fibronectin Level as a Biomarker of Preeclampsia
Authors: Yasumizu Takehiko , Kato Junzo 
Published: August 2010

AbstractObjective: To evaluate the clinical feasibility of plasma fibronectin as a biomarker and predictor for preeclampsia.Methods: A total of 13 patients who had severe preeclampsia in prior pregnancies were enrolled for longitudinal study, and the profiles of plasma fibronectin were observed throughout their pregnancies. In cross‐sectional study, the correlation between plasma fibronectin within a week before delivery and the grade of preeclampsia were analyzed in 96 pregnant women including tangible preeclampsia.Results: In the longitudinal study, 5 patients developed severe preeclampsia, in whom plasma fibronectin was elevated over the normal range 2–9 weeks before the onset of preeclampsia. In the cross‐sectional study, plasma fibronectin levels elevated significantly corresponding with the severity of preeclampsia, and the abnormal elevation of fibronectin reflected the existence of preeclampsia with satisfactory sensitivity and specificity.Conclusion: Increased plasma fibronectin levels may be a highly sensitive and specific diagnostic indicator for preeclampsia.
Effect of Estriol on Bone Loss in Postmenopausal Japanese Women: A Multicenter Prospective Open Study
Authors: Minaguchi Hiroshi , Uemura Tsuguo , Shirasu Kazuhiro , Sato Akira , Tsukikawa Susumu , Ibuki Yoshito , Mizunuma Hideki , Aso Takeshi , Koyama Takao , Nozawa Shiro , Ohta Hiroaki , Ikeda Toshiyuki , Kusuhara Koji , Ochiai Kazuhiko , Kato Junzo , Kinoshita Toshihiko , Tanaka Kenichi , Minagawa Yusuke , Kurabayashi Takumi , Fukunaga Masao 
Published: August 2010

AbstractObjectives: To assess the effects of oral estriol on the bone mineral density (BMD) and bone metabolism in postmenopausal women.Methods: Seventy‐five natural postmenopausal women with a BMD of more than 10% below the peak bone density were treated for 50 weeks with 2 mg/day estriol (E3) cyclically and 0.8 g/day of calcium lactate continuously. BMDs at L2‐L4 were measured by dual energy X‐ray absorptiometry (DXA).Results: The BMD increased 1.79% (p < 0.01 vs. pretreatment) after 50 weeks, accompanied with decrease of biochemical markers of bone turnover. With regard to climacteric symptoms, Kupperman's menopausal index improved (p < 0.01 vs. pre‐treatment) after 5 weeks of treatment. As to the incidence of adverse events genital bleeding was observed in only 8.0% of the subjects. Endometrial histology and cytology showed neither abnormalities nor hyperplasia during and after the treatment.Conclusions: Estriol prevented postmenopausal bone loss and improved climacteric symptoms effectively with low incidence of genital bleeding.
Gestational Changes in Nitric Oxide Synthase Activity in the Rat Placenta
Authors: Thanda Myat , Saheki Shuichi , Kitagawa Hiroyuki , Yano Juri , Matsuura Shumpei 
Published: August 2010

AbstractObjective:To assess the importance of nitric oxide (NO) generated in the placenta on pregnancy, nitric oxide synthase (NOS) activities were measured in the rat placentas of different gestational ages.Materials and Methods:NOS activity was determined by [3H] L‐arginine to [3H]‐citrulline conversion assay on rat placenta of day 5, 10, 15 and 21 of gestation.Results:NOS activity distributed both in the soluble and particulate fractions. Inhibition of NOS activity by L‐arginine analogs confirmed the substrate specificity. The requirement of calcium/calmodulin for the maximal activity indicated that the rat placenta NOS was of a constitutive calcium/calmodulin dependent isoform. The activities in both fractions were higher in the earlier gestational age placentas, decreasing with progression of gestation, and the lowest in the term placentas.Conclusion:Although NOS activity was detected in the placenta throughout gestation, it was highest in the early gestational age placenta, suggesting a possible significant role of NO in early gestation.
Anti‐Phospholipid Antibodies in Preeclampsia and Their Binding Ability for Placental Villous Lipid Fractions
Authors: Yamamoto Tatsuo , Takahashi Yuko , Geshi Yumi , Sasamori Yukifumi , Mori Hirouki 
Published: August 2010

AbstractObjective: In order to investigate the significance of the anti‐phospholipid antibodies (APAs) in preeclampsia, 3 kinds of APAs — namely, the anti‐cardiolipin antibody (ACA), the anti‐phosphatidylserine antibody (APSA), and the anti‐phosphatidylcholine antibody (APCA) — were measured, and the APA‐binding ability for placental villi using villous lipid fractions was studied.Methods: Serum samples were taken from 70 cases of preeclampsia, including 42 cases of the severe type, and from 45 normal pregnant women. The APAs were measured by an enzyme linked immunoabsorbent assay (ELISA). Placental villous membranes (PVMs) from normal placenta were purified and the lipid fractions were extracted from PVMs. The antibody‐binding ability for PVM lipid fractions was evaluated by the ELISA method.Results: In IgG‐antibody measurements, the rate of ACA‐positive, APSA‐positive and APCA‐positive cases were 10.0%, 18.1%, and 7.1%, respectively. The presence of APAs was revealed in preeclampsia. Using thin‐layer chromatography, negatively charged phospholipids were found in the lipid fractions obtained from PVMs. Antibody binding for the lipid fractions of PVMs was detected in 9 of 12 APA‐positive cases in preeclampsia.Conclusion: The results suggest that one cause of preeclampsia is the production of antiphospholipid antibodies that bind to placental villous membrane antigens.
Immunohistochemical Study of c‐erb B‐2 Expression in Malignant Mixed Müllerian Tumors of the Female Genital Tract
Authors: Nasu Kaei , Kawano Yasushi , Hirota Yoshiko , Matsui Naohiko , Hayata Takashi , Miyakawa Isao 
Published: August 2010

AbstractObjective: To study the expression of c‐erb B‐2 in gynecologic malignancies, especially in malignant mixed müllerian tumors (MMTs).Methods: Using immunohistochemical techniques, we examined 6 cases of primary MMT, 6 cases of leiomyosarcoma (LMS), 7 cases of endometrial adenocarcinomas, and 10 cases of normal endometria.Results: The expression of c‐erb B‐2 was observed in the carcinomatous area of all 6 cases of MMT (100%), the sarcomatous area of 5 of 6 cases of MMT (83.3%), in 1 of the 6 cases of LMS (16.7%), in all 7 cases of adenocarcinoma (100%), and in all cases of normal epithelial cells (100%), but was not observed in any of the cases of normal stromal cells (0%).Conclusion: The results suggest that the carcinomatous and sarcomatous elements of MMT are similar in their expression of c‐erb B‐2. MMT differed immunohistochemically from pure sarcoma cells and normal stromal cells, but resembled pure carcinoma cells and normal epithelial cells of the female genital tract.
The Relation between Body‐Fat Distribution and Lipid Metabolism in Postmenopausal Women
Authors: Douchi Tsutomu , Ijuin Hirofumi , Nakamura Sachiko , Oki Toshimichi , Yamamoto Shinichi , Katanozaka Mari , Nagata Yukihiro 
Published: August 2010

AbstractObjective: To evaluate the relationship between body‐fat distribution and lipid metabolism in postmenopausal women.Methods: Fifty‐four women (mean: 61.8 ± 7.8 years old) showing hyperlipidemia and 63 controls were enrolled in this study. Their baseline characteristics and body‐fat indices, as measured by DEXA, were compared. The correlations between the serum‐lipid levels and the variables were evaluated.Results: The amount of upper‐half‐body fat and the body‐fat ratio were significantly higher in the hyperlipidemia group. In single‐regression analysis, there were low levels of correlation between the serum TC levels and the amount of upper‐half‐ body fat and the upper‐body fat ratio. There was a low level of correlation between the serum TG level and the amount of upper‐half‐body fat, the upper‐lower‐half‐ body‐fat ratios, and the upper‐half‐body‐fat ratio. After adjusting for variables, the serum TC and TG levels best correlated with the amount of upper‐half‐body‐fat (r = 0.458, r = 457, respectively).Conclusion: In postmenopausal women, lipid metabolism is reflected in the amount of upper‐half‐body fat, irrespective of age and the body‐mass index (BMI).