bluuebunny/crossref_metadata_2025_split huggingface dataset:
SKIN MICROBIOTA IN PSORIASIS
Authors: Орлина Маргарита Анатольевна , Голубева Алёна Алексеевна , Земборская Татьяна Николаевна , Ломовцева Виктория Алексеевна , Фрицлер Валерия Александровна 
Published: June 2024

Микробиома кожи представляет собой сложную экосистему, включающую в себя различные виды микроорганизмов, которые взаимодействуют не только друг с другом, но и с окружающей средой, включая эпителиальные и иммунные клетки хозяина. Эти взаимодействия играют ключевую роль в поддержании здоровья кожи, усиливая ее барьерные функции. Однако, как и в любой сложной системе, существует риск дисбаланса. Резидентные микробы кожи могут вести себя по-разному в зависимости от изменений в окружающей среде и состоянии хозяина. Таким образом, данное научное исследование рассматривает роль микробиомы кожи в патогенезе псориаза и возможности использования пробиотиков и других методов микробиомной терапии для улучшения состояния кожи при этом заболевании.
The skin microbiome is a complex ecosystem that includes various types of microorganisms that interact not only with each other, but also with the environment, including epithelial and immune cells of the host. These interactions play a key role in maintaining skin health by enhancing its barrier functions. However, as with any complex system, there is a risk of imbalance. Resident skin microbes may behave differently depending on changes in the environment and the condition of the host. Thus, this scientific study examines the role of the skin microbiome in the pathogenesis of psoriasis and the possibility of using probiotics and other microbiome therapies to improve skin condition in this disease.
PREVENTION OF HPV INFECTIONS IN ADOLESCENT GIRLS
Authors: Орлина Маргарита Анатольевна , Вергилесов Дмитрий Павлович , Батаева Ксения Игоревна , Латышева Дарья Сергеевна 
Published: June 2024

Вирус папилломы человека: вакцинация как приоритет профилактики является наиболее распространенным вирусом, передающимся половым путем. Он является одной из серьезных проблем здравоохранения во всем мире. Некоторые типы ВПЧ (известные как ВПЧ высокого риска) являются основными этиологическими агентами рака половых путей, таких как рак шейки матки, рак вульвы, влагалища, полового члена и анального канала, а также некоторых видов рака головы и шеи. Вакцинация против ВПЧ является приоритетной задачей в профилактике инфицирования этим вирусом. Однако относительно малая продолжительность применения вакцин и их отсутствие в Национальной программе вакцинации вызывают дискуссии о безопасности иммунизации. Высокая стоимость вакцин также ограничивает их широкое использование. Профилактика, а именно вакцинация, является основным методом защиты от ВПЧ. Вакцины против ВПЧ безопасны и эффективны в предотвращении развития раковых заболеваний, связанных с ВПЧ. Они показаны как мальчикам, так и девочкам в возрасте 9-12 лет с целью создания иммунитета до начала половой активности. Несмотря на доказанную эффективность вакцин против ВПЧ, охват вакцинацией остается на низком уровне во многих странах. Необходимо повышать осведомленность о ВПЧ и его последствиях, а также о преимуществах вакцинации. Расширение доступа к вакцинам против ВПЧ для всех возрастных групп, в том числе взрослых, и включение их в Национальную программу вакцинации позволит значительно снизить заболеваемость и смертность от раковых заболеваний, связанных с ВПЧ.
Human papillomavirus: Vaccination as a prevention priority Human papillomavirus (HPV) is the most common sexually transmitted virus. It is one of the major health problems worldwide. Some types of HPV (known as high-risk HPV) are the main etiological agents of genital tract cancers, such as cervical cancer, vulvar, vaginal, penile and anal cancers, as well as some types of head and neck cancers. HPV vaccination is a priority in preventing infection with this virus. However, the relatively short duration of vaccine use and their absence from the National Vaccination Program are causing discussions about the safety of immunization. The high cost of vaccines also limits their widespread use. Prevention, namely vaccination, is the main method of protection against HPV. HPV vaccines are safe and effective in preventing the development of HPV-related cancers. They are shown to both boys and girls aged 9-12 years in order to create immunity before sexual activity begins. Despite the proven effectiveness of HPV vaccines, vaccination coverage remains low in many countries. There is a need to raise awareness about HPV and its effects, as well as the benefits of vaccination. Increasing access to HPV vaccines for all age groups, including adults, and including them in the National Vaccination Program will significantly reduce the incidence and mortality from HPV-related cancers.
Nghiên cứu độc tính cấp và kết quả điều trị đau thắt lưng do thoái hóa cột sống của cao lỏng TK-VNC kết hợp điện châm
Authors: Hồ Công Mệnh , Trần Thị Hồng Ngãi , Nguyễn Thế Anh 
Published: June 2024

Mục tiêu: Nghiên cứu độc tính cấp và kết quả điều trị đau thắt lưng do thoái hóa của Cao lỏng TK-VNC kết hợp điện châm.
Đối tượng và phương pháp: 100 chuột nhắt trắng chủng Swiss, cả 2 giống, khoẻ mạnh, trọng lượng 18 - 22g và so sánh trước và sau điều trị trên 60 bệnh nhân được chẩn đoán xác định thoái hoá cột sống thắt lưng theo YHHĐ và Chứng tý thể phong hàn thấp tý kèm can thận hư theo YHCT.
Kết quả: Liều dung nạp tối đa (luôn nhỏ hơn liều chết 50%) của cao lỏng TK-VNC là 183gam dược liệu/kg chuột. Cải thiện chỉ số VAS: sau 30 ngày điều trị hiệu quả giảm đau rõ rệt so với trước đều trị và có ý nghĩa thống kê với 30% bệnh nhân hết triệu chứng đau, 70% bệnh nhân chỉ còn đau nhẹ và không có bệnh nhân nào có tiến triển đau nặng thêm. Sau 30 ngày sử dụng thuốc, cao lỏng TK – VNC không gây các tác dụng phụ trên lâm sàng cũng như cận lâm sàng như thay đổi chức năng hệ thống tạo máu, chức năng gan, thận ở các bệnh nhân rối loạn chuyển hóa lipid máu.
Kết luận: LD50 của cao lỏng TK-VNC là 183gam dược liệu/kg chuột.
Cao lỏng TK-VNC kết hợp điện châm chứng minh có tác dụng giảm đau, cải thiện vận động và cải thiện chất lượng sống qua thang điểm NPQ trên bệnh nhân đau thắt lưng do thoái hóa cột sống thắt lưng, đồng thời không ghi nhận tác dụng phụ trên lâm sàng, cận lâm sàng.
Biomass and organic waste conversion for sustainable bioenergy: A comprehensive bibliometric analysis of current research trends and future directions
Authors: Alao Kehinde Temitope , Gilani Syed Ihtsham-ul-Haq , Sopian Kamaruzzaman , Alao Taiwo Onaopemipo , Oyebamiji Damilare Samuel , Oladosu Temidayo L 
Published: June 2024

The rising demand for renewable energy sources has fueled interest in converting biomass and organic waste into sustainable bioenergy. This study employs a bibliometric analysis (2013-2023) of publications to assess trends, advancements, and future prospects in this field. The analysis explores seven key research indicators, including publication trends, leading contributors, keyword analysis, and highly cited papers. We begin with a comprehensive overview of biomass as a renewable energy source and various waste-to-energy technologies. Employing Scopus and Web of Science databases alongside Biblioshiny and VOSviewer for analysis, the study investigates publication patterns, citation networks, and keyword usage. This systematic approach unveils significant trends in research focus and identifies prominent research actors (countries and institutions). Our findings reveal a significant increase in yearly publications, reflecting the growing global focus on biomass and organic waste conversion. Leading contributors include China, the United States, India, and Germany. Analysis of keywords identifies commonly used terms like "biofuels," "pyrolysis," and "lignocellulosic biomass." The study concludes by proposing future research directions, emphasizing advanced conversion technologies, integration of renewable energy sources, and innovative modelling techniques.
A Fourier series model and parametric study for single person three-way continuous walking load
Authors: Li Ping 
Published: June 2024

The characteristics and mathematical model of the walking load is the basis for studying human-induced vibration in large-span flexible structures. In this paper, 2842 sets of effective walking load datum were collected by three-way force plate test. The correlation analysis shows that the correlations between the vertical component, the horizontal component and the longitudinal component of the walking load are weak, the Fourier series models of the three directional components of the walking load are established. The model parameters of the dynamic loading factor, the phase angle and the walking frequency function with respect to walking frequency are analyzed statistically, and the function of dynamic load factor and phase angle with respect to walking frequency are obtained respectively. Compared with the existing walking load model, it shows that there are some differences from the former models.
Hubungan Tingkat Pengetahuan Dengan Kepatuhan Minum Obat Anti Hipertensi Pasien Di Puskesmas Bangkuang Kalimantan Tengah
Authors: Kamelia citra Mia , Kurniawati Darini , Fajriannor TM M. 
Published: June 2024

Hipertensi merupakan salah satu penyakit kronis sillent killer yang menyebabkan kematian hingga 427.218 jiwa di Indonesia. Ketidakpatuhan terhadap terapi merupakan salah satu faktor yang menyebabkan peningkatan prevalensi penderita hipertensi. Oleh karena itu, tingkat pengetahuan terhadap obat antihipertensi menjadi faktor utama yang mempengaruhi perilaku kepatuhan penderita hipertensi, sehingga tingkat pengetahuan akan menunjang keberhasil terapi dengan antihipertensi. Tujuan penelitian ini adalah untuk mengetahui tingkat pengetahuan obat antihipertensi dengan kepatuhan minum obat antihipertensi pada pasien hipertensi di Puskesmas Bangkuang. Penelitian kuantitatif dengan metode observasional analitik melalui pendekatan cross sectional. Teknik pengambilan sampel adalah acidental sampling. Pengumpulan data dengan menggunakan kuesioner pengetahuan dan kuesioner kepatuhan hill-bone. Penelitian dilakukan di Puskesmas Bangkuang, Kalimantan Tengah dalam waktu satu bulan yaitu mulai dari 22 Mei– 22 Juni 2023. Berdasarkan hasil penelitian diketahui bahwa responden memiliki tingkat pengetahuan kategori baik 69,52% dan kurang baik 30,48%. Berdasarkan kepatuhan, rseponden dengan kategori patuh 54,29% dan tidak patuh 45,71%. Hasil uji spearman rho menunjukkan nilai signifkansi 0,000 (p value 0,000 < 0,05) yang dimaknai bahwa adanya hubungan yang signifikan antara tingkat pengetahuan dan kepatuhan pasien. Disimpulkan bahwa adanya hubungan antara tingkat pengetahuan obat antihipertensi dan kepatuhan minum obat antihipertensi pada pasien hipertensi di Puskesmas Bangkuang
The Impact of High BMI on Cholesterol Levels and Type-2 Diabetes Control. A Cross-Sectional Study
Authors: Haq Zainab , Zaidi Syed Usama Shayan , Shahid Muhammad Nauman , Waseem Ali Bin , Tahir Ibrahim , Munir Maria , Butt Tahreem Waheed , khan Ihsan Ullah , Javaid Saad 
Published: June 2024

Background: Higher levels of BMI have closed relationship with hypercholesterolemia and glycated hemoglobin (HbA1c) in the population with type 2 diabetes.
Study Design: Present research was a Cross-Sectional Study.
Methodology: Current study was conducted at Lahore General Hospital, Jinnah hospital Lahore and Diabetes Endocrine Metabolic Centre (DEMC) from March 2023 to February 2024. A retrospective Cross-Sectional analysis of 800 patients was considered and correlation between BMI, HbA1c and hypercholesterolemia was noted. The Underweight, Normal, Overweight, Obesity Class 1, Obesity Class 2, and Obesity Class 3 were the six categories based on BMI. One could classify HbA1c as controlled or uncontrolled. One could take cholesterol as controlled or uncontrolled.
Results:For above 500 patients, 25 percent had normal weight, 30.1% were overweight, and 35 percent were obese. Class 1 had a 25.8% obesity rate, Class 2 had a 40% obesity rate, and Class 3 had a 42 % obesity rate. Both sexes showed similar levels of obesity, HbA1c, and cholesterol control. Whereas 32.26% of patients had a controlled HbA1c. Of them, 7.8% had normal weight, 11.8% were overweight, and 0.98% were underweight. In this class, 11.8% of the patients were obese. Class 1 obesity rates were 6.2%, Class 2 obesity rates were 4.3%, and Class 3 obesity rates were 1.2%. 1.9% of patients with uncontrolled HbA1c levels were underweight, 18.2% were of normal weight, 22.1% were overweight, and 26.3% were obese out of 67.74% of patients. Class 1 obesity rates were 18.7%, Class 2 obesity rates were 6.3%, and Class 3 obesity rates were 1.4%.
Conclusion:The findings of present study were showed that BMI has close relationship with HbA1c. And hypercholesterolemia. High levels of BMI had poor glycemic and Cholesterol control.
ENHANCING STUDENTS’ WRITING SKILL BY USING BRAINSTORMING STRATEGY
Authors: NURHIKMAH ZIZI 
Published: June 2024

This research has aim for increasing students’ writing skill. For increasing students’ skill, it is needed an effective strategy. This research used brainstorming for it. In the method, the researcher used Classroom Action Research. It had done for 2 cycles with total six meeting. Two meetings was for test and four meetings were for treatment.The population of this research was the tenth grade students from eleventh grade students of Marketing at Vocational High School of Sunan Kalijogo Malang. Academic year 2022/2023. The students’ average was 60 then after the implementation brainstorming their cycle changed into 77,43. It showed that brainstorming strategy can improve students’ writing skill.
Construction of a nomogram for predicting catheter-related bladder discomfort in patients with end-stage renal disease after renal transplantation: a retrospective study
Authors: Liu Kao , Liu Shengli , Peng Zhiguo , Li Na , Sun Huaibin 
Published: June 2024

Background
The incidence of catheter-related bladder discomfort (CRBD) is relatively high in the end-stage renal disease (ESRD) patients who underwent renal transplantation (RT). This study was designed to establish a nomogram for predicting CRBD after RT among ESRD patients.

Methods
In this retrospective study, we collected 269 ESRD patients who underwent RT between September 2019 and August 2023 in our hospital. The patients were divided into training set (n = 215) and test set (n = 54) based on a ratio of 8:2. Univariate and multivariate logistic regression analyses were utilized to identify the risk factors associated with CRBD after RT, and then a nomogram model was constructed. Receiver operating characteristic (ROC) and calibration curve were used to evaluate the predicting efficiency of the established nomogram.

Results
Multivariate logistic regression analysis showed that aberrant body mass index (BMI) (underweight: OR = 5.25; 95% CI [1.25–22.15], P = 0.024; overweight: OR = 2.75; 95% CI [1.17–6.49], P = 0.021), anuria (OR = 2.86; 95% CI [1.33–5.88]) and application of double J (DJ) stent with a diameter of >5Fr (OR = 15.88; 95% CI [6.47–39.01], P < 0.001) were independent risk factors for CRBD after RT. In contrast, sufentanil utilization (>100 µg) [OR = 0.39; 95% CI [0.17–0.88], P = 0.023] was associated with decreased incidence of CRBD. A nomogram was then established based on these parameters for predicting the occurrence of CRBD after RT. Area under the ROC curve (AUC) values and calibration curves confirmed the prediction efficiency of the nomogram.

Conclusion
A nomogram was established for predicting CRBD after RT in ESRD patients, which showed good prediction efficiency based on AUC and calibration curves.
Differential Distribution Patterns From Medial Prefrontal Cortex and Dorsal Raphe to the Locus Coeruleus in Rats
Authors: Lu Yuefeng , Simpson Kimberly L. , Weaver Kristin J. , Lin Rick C.S. 
Published: June 2012

AbstractLocus coeruleus (LC) consists of a densely packed nuclear core and a surrounding plexus of dendritic zone, which is further divided into several subregions. Whereas many limbic‐related structures topographically target specific subregions of the LC, the precise projections from two limbic areas, that is, medial prefrontal cortex (mPFC) and dorsal raphe (DR), have not been investigated. The goal of the present study is to identify and compare the distribution patterns of mPFC and DR afferent terminals to the LC nuclear core as opposed to specific pericoerulear dendritic regions (Peri‐LC). To address these issues, anterograde tracer injections were combined with dopamine‐β‐hydroxylase (DBH) immunofluorescent staining to reveal the distribution patterns around the LC nuclear complex. Our data suggest that both mPFC‐LC and DR‐LC projections exhibit selective afferent terminal patterns. More specifically, mPFC‐LC projecting fibers mainly target the rostromedial Peri‐LC, whereas DR‐LC projecting fibers demonstrate a preference to the caudal juxtaependymal Peri‐LC. Thus, our present findings provide further evidences that afferents to the LC are topographically organized. Understanding the relationship among different inputs to the LC may help to elucidate the organizing principle which likely governs the interactions between the broad afferent sources of the LC and its global efferent targets. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc.
Comparison of Three Methods of Drug Delivery in the Rat Lumbar Spinal Subarachnoid Space
Authors: Chen Liming , Jiang Meng , Pei Lei 
Published: June 2012

AbstractThis study aimed to compare three most widely used surgeries for experimental lumbar spinal drug delivery in rats. The comparison consisted of assessing the effects of the surgeries and evaluating the deficits produced by these three methods. Sprague Dawley rats underwent acute needle puncture, chronic catheterization via laminectomy or nonlaminectomized catheterization. Body weight changes were measured, animals' general and neurological conditions were observed after surgeries, and motor function was examined by Rota Rod test both prior to and post surgery. Furthermore, nociceptive tests were performed to assess the animals' nociception; hematoxylin, and eosin staining of lumbar spinal cord tissue was performed to evaluate local inflammation caused by surgeries; and both lidocaine paralysis detection; and toluidine blue dye assay were used to confirm the exact location of the catheter. Both needle puncture and catheterization via laminectomy had relatively low success rate of surgery and induced various neurological signs; more severe motor dysfunction, hyperalgesia, allodynia, and local inflammation. Nonlaminectomized catheterization had a higher success rate of surgery, and induced only mild agitation, slight cerebral spinal fluid leakage, mild sensory and motor abnormalities, and minimum pathology in the lumbar spinal cord. The nonlaminectomized catheterization used in this study induces a phenotype of less detectable effects on the animal's behavior and is well‐tolerated compared to the acute needle puncture and laminectomized catheterization that are widely used in the literature. Nonlaminectomized catheterization is a safe, accurate and effective way for lumbar drug delivery in rats. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc.
Receptor‐interacting protein (RIP) and Sirtuin‐3 (SIRT3) are on opposite sides of anoikis and tumorigenesis
Authors: Kamarajan Pachiyappan , Alhazzazi Turki Y. , Danciu Theodora , D'silva Nisha J. , Verdin Eric , Kapila Yvonne L. 
Published: June 2012

AbstractBACKGROUND:Regulating cross‐talk between anoikis and survival signaling pathways is crucial to regulating tissue processes and mitigating diseases like cancer. Previously, the authors demonstrated that anoikis activates a signaling pathway involving the CD95/Fas‐mediated signaling pathway that is regulated by receptor‐interacting protein (RIP), a kinase that shuttles between Fas‐mediated cell death and integrin/focal adhesion kinase (FAK)‐mediated survival pathways. Because it is known that sirtuin‐3 (SIRT3), a nicotinamide adenine dinucleotide‐dependent deacetylase, regulates cell survival, metabolism, and tumorigenesis, the authors hypothesized that SIRT3 may engage in cross‐talk with Fas/RIP/integrin/FAK survival‐death pathways in cancer cell systems.METHODS:Using immunohistochemical staining, immunoblotting, human tissue microarrays, and overexpression and suppression approaches in vitro and in vivo, the roles of RIP and SIRT3 were examined in oral squamous cell carcinoma (OSCC) anoikis resistance and tumorigenesis.RESULTS:RIP and SIRT3 had opposite expression profiles in OSCC cells and tissues. Stable suppression of RIP enhanced SIRT3 levels, whereas stable suppression of SIRT3 did not impact RIP levels in OSCC cells. The authors observed that, as OSCC cells became anoikis‐resistant, they formed multicellular aggregates or oraspheres in suspension conditions, and their expression of SIRT3 increased as their RIP expression decreased. Also, anoikis‐resistant OSCC cells with higher SIRT3 and low RIP expression induced an increased tumor burden and incidence in mice, unlike their adherent OSCC cell counterparts. Furthermore, stable suppression of SIRT3 inhibited anoikis resistance and reduced tumor incidence.CONCLUSIONS:The current results indicted that RIP is a likely upstream, negative regulator of SIRT3 in anoikis resistance, and an anoikis‐resistant orasphere phenotype defined by higher SIRT3 and low RIP expression contributes to a more aggressive phenotype in OSCC development. Cancer 2012. © 2012 American Cancer Society.
Identification of seven serum microRNAs from a genome‐wide serum microRNA expression profile as potential noninvasive biomarkers for malignant astrocytomas
Authors: Yang Cuihua , Wang Cheng , Chen Xi , Chen Sidi , Zhang Yanni , Zhi Feng , Wang Junjun , Li Limin , Zhou Xiaojun , Li Nanyun , Pan Hao , Zhang Junfeng , Zen Ke , Zhang Chen‐Yu , Zhang Chunni 
Published: June 2012

AbstractThe involvement of circulating microRNAs (miRNAs) in cancer and their potential as biomarkers of diagnosis and prognosis are becoming increasingly appreciated; however, little is known about circulating miRNA profiles in astrocytomas. In our study, we performed genome‐wide serum miRNA analysis by the Solexa sequencing followed by validation conducted in the training and verification sets with a stem‐loop quantitative reverse‐transcription PCR (RT‐qPCR) assay from serum samples of 122 untreated astrocytomas patients (WHO grades III–IV) and 123 normal controls. Identified miRNAs were subsequently examined in 55 grade II, 15 grade I astrocytomas, 11 astrogliosis, 42 other primary brain tumors and 8 tumor tissues from grades II–IV astrocytomas. In addition, paired serum samples before and after operation were collected from 14 malignant astrocytomas to determine the effect of surgery on the miRNAs' levels. A marked difference in serum miRNA profile was observed between high‐grade astrocytomas and normal controls. Seven miRNAs were validated by RT‐qPCR assay to be significantly decreased in grades II–IV patients (p < 0.001), including miR‐15b*, miR‐23a, miR‐133a, miR‐150*, miR‐197, miR‐497 and miR‐548b‐5p, and the seven‐miRNA panel demonstrated a high sensitivity (88.00%) and specificity (97.87%) for malignant astrocytomas prediction. These identified miRNAs also exhibited a global decrease in tumor tissues relative to normal tissues. Furthermore, these miRNAs in serum were markedly elevated after operation (p < 0.001). In addition, some of these serum miRNAs were significantly different between malignant and benign cases, astrogliosis and other primary brain tumors. The seven serum miRNAs identified in our study hold potential as noninvasive biomarker for malignant astrocytomas.