bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of the median preoptic nucleus in the development of chronic deoxycorticosterone acetate (DOCA)‐salt hypertension
Authors: Collister John P. , Fritcher Nora , Nahey David 
Published: May 2024

AbstractWe have previously reported that the subfornical organ (SFO) does not contribute to the chronic hypertensive response to DOCA‐salt in rats, and yet the organum vasculosum of the lamina terminalis (OVLT) plays a significant role in the development of deoxycorticosterone acetate (DOCA)‐salt hypertension. Since efferent fibers of the OVLT project to and through the median preoptic nucleus (MnPO), the present study was designed to test the hypothesis that the MnPO is necessary for DOCA‐salt hypertension in the rat. Male Sprague‐Dawley rats underwent SHAM (MnPOsham; n = 5) or electrolytic lesion of the MnPO (MnPOx; n = 7) followed by subsequent unilateral nephrectomy and telemetry instrumentation. After recovery and during the experimental protocol, rats consumed a 0.1% NaCl diet and 0.9% NaCl drinking solution. Mean arterial pressure (MAP) was recorded telemetrically 5 days before and 21 days after DOCA implantation (100 mg/rat; SQ). The chronic pressor response to DOCA was attenuated in MnPOx rats by Day 11 of treatment and continued such that MAP increased 25 ± 3 mmHg in MnPOsham rats by Day 21 of DOCA compared to 14 ± 3 mmHg in MnPOx rats. These results support the hypothesis that the MnPO is an important brain site of action and necessary for the full development of DOCA‐salt hypertension in the rat.
Catalysis effect of rare earth element Ce on paste boriding treatment of AISI 410 steel
Authors: Shi Mingxiao , Li Jingyong , Mao Weidong , Li Shengliang , Yang Zhidong , Ma Xiang 
Published: May 2024

Abstract
Surface hardening techniques of steel are of great practical interest for applications in various industrial sectors. Boriding is one of the most economical choices. However, the chief deterrent to the widespread application of the technique is the difficulty in attaining a thick, dense boride layer. To solve this problem, a paste boriding process was performed on the surface of AISI 410 steel by introducing 6 wt.% CeO2 addition into the boriding agent. The microstructure of the boride layer is comprised of (Fe, Cr)B and (Fe, Cr)2B, which lie in the external and internal layers of the boride layer, respectively. CeO2 addition makes it possible to prepare a thick, dense boride layer on the surface of the steel substrate, thereby improving both wear and corrosion resistance of the steel. The catalysis mechanism of the rare earth element Ce can be ascribed to three aspects. First, CeO2 addition can take part in the chemical reactions involved in the boriding process to produce more active boron atoms. Second, Ce can facilitate the adsorption of active boron atoms onto the surface of the steel through preventing the formation of iron oxides on the steel’s surface. Third, Ce can diffuse into the surface of the steel and generate severe lattice distortion due to large atomic size, thereby promoting the boron diffusion. These results provide a high-quality, low-cost pathway for the surface hardening of steel in practical industrial applications.
The quasi-binary phase diagrams of R
2Fe14B–Ce2Fe14B (R = Nd, Pr) systems
Authors: Xu Chengfu , Fu Senyang , Peng Ling , Yang Yongquan , Gao Xinqiang , Ma Lei , Tian Jinping , Liu Rongjin , Gu Zhengfei , Yao Qingrong , Rao Guanghui , Cheng Linyi 
Published: May 2024

Abstract
The phase relations of the R
2Fe14B–Ce2Fe14B (R = Nd, Pr) pseudobinary systems have been investigated by using X-ray powder diffraction, scanning electron microscopy equipped with energy dispersive X-ray spectroscopy and differential thermal analysis. The X-ray powder diffraction results show that continuous solid solutions were formed in this R
2Fe14B–Ce2Fe14B (R = Nd, Pr) pseudobinary systems, and all (R
, Ce)2Fe14B solid solutions belong to the tetragonal structure with space group P42/mnm. With the increase in Ce content, the lattice parameters a, c, the peritectic reaction temperatures of the (R, Ce)2Fe14B (R = Nd, Pr) solid solutions decrease linearly, and the cell volume V varies in the form of the regression line. Based on the X-ray powder diffraction results and differential thermal analysis data, the quasi-binary phase diagrams of the R
2Fe14B–Ce2Fe14B (R = Nd, Pr) systems have been established.
On algebraic normalisers of maximal tori in simple groups of Lie type
Authors: Baykalov Anton A. 
Published: May 2024

Abstract
Let 𝐺 be a finite simple group of Lie type and let 𝑇 be a maximal torus of 𝐺.
It is well known that if the defining field of 𝐺 is large enough, then the normaliser of 𝑇 in 𝐺 is equal to the algebraic normaliser

N
⁢

(
G
,
T
)

N(G,T)

.
We identify explicitly all the cases when

N
G

⁢

(
T
)

N_{G}(T)

is not equal to

N
⁢

(
G
,
T
)

N(G,T)

.
Groups whose proper subgroups of infinite rank have a permutability transitive relation
Authors: Ballester Bolinches Adolfo , De Falco Maria , de Giovanni Francesco , Musella Carmela 
Published: May 2024

Abstract
Let 𝐺 be a group.
A subgroup 𝐻 of 𝐺 is called permutable if

H
⁢
X

=

X
⁢
H

HX=XH

for all subgroups 𝑋 of 𝐺.
Permutability is not in general a transitive relation, and 𝐺 is called a

PT

\mathrm{PT}

-group if, whenever 𝐾 is a permutable subgroup of 𝐺 and 𝐻 is a permutable subgroup of 𝐾, we always have that 𝐻 is permutable in 𝐺. The property

PT

\mathrm{PT}

is not inherited by subgroups, and 𝐺 is called a

PT
̄

\overline{\mathrm{PT}}

-group if all its subgroups have the

PT

\mathrm{PT}

-property.
We prove that if 𝐺 is a soluble group of infinite rank whose proper subgroups of infinite rank have the

PT

\mathrm{PT}

-property, then 𝐺 is a

PT
̄

\overline{\mathrm{PT}}

-group.
Prognostic value of EIF5A2 in solid tumors: A meta-analysis and bioinformatics analysis
Authors: Fang Jianwen , Yu Tianze , Jiang Xiaocong , Lu Yuexin , Shang Xi , Shen Haixing , Lu Yue , Zheng Jingyan , Fu Peifen 
Published: May 2024

Abstract

Aims
In cancer biology, the aberrant overexpression of eukaryotic translation initiation factor 5A2 (EIF5A2) has been correlative with an ominous prognosis, thereby underscoring its pivotal role in fostering metastatic progression. Consequently, EIF5A2 has garnered significant attention as a compelling prognostic biomarker for various malignancies. Our research endeavors were thus aimed at elucidating the utility and significance of EIF5A2 as a robust indicator of cancer outcome prediction.

Method
An exhaustive search of the PubMed, EMBASE, and Web of Science databases found relevant studies. The link between EIF5A2 and survival prognosis was examined using hazard ratios and 95% confidence intervals. Subsequently, The Cancer Genome Atlas (TCGA) and the Gene Expression Profiling Interactive Analysis (GEPIA) databases were employed to validate EIF5A2 expression across various cancer types.

Results
Through pooled analysis, we found that increased EIF5A2 expression was significantly associated with decreased overall survival (OS) and disease-free survival/progression-free survival/relapse-free survival (DFS/PFS/RFS). Moreover, TCGA analysis revealed that EIF5A2 was significantly upregulated in 27 types of cancer, with overexpression being linked to shorter OS in three, worse DFS in two, and worse PFS in six types of cancer. GEPIA showed that patients with EIF5A2 overexpression had reduced OS and DFS.

Conclusions
In solid tumors, EIF5A2 emerges as a reliable prognostic marker. Our meta-analysis comprehensively analyzed the prognostic value of EIF5A2 in solid tumors and assessed its efficacy as a predictive marker.
Albert Camus and Rachel Bespaloff: Happiness in a Challenging World
Authors: Lombard Cécilia Andrée Monique 
Published: May 2024

Abstract
Albert Camus and Rachel Bespaloff had an undeniable influence on the existential thought of the twentieth century. The former, by claiming the world to be silent to our search for meaning, based the concept of happiness in the inherent value of life. The latter grounded her happiness in music and transcendence rather than in the acceptance of the absurd human condition, though the two thinkers seem to agree on the importance of subjective contemplation. In this article, I will offer a reading of Camus’s works that emphasizes his view of happiness in awareness of the absurd. I will then argue for the ethical and political challenges that such happiness causes. Finally, by putting into dialogue the philosophies of Camus and Bespaloff, I wish to show that the two thinkers advocate for the possibility of happiness despite the suffering of the world, and show that this concept, understood as contemplation, can be rooted in the absurd as well as in transcendence.
Flexible model-based non-negative matrix factorization with application to mutational signatures
Authors: Laursen Ragnhild , Maretty Lasse , Hobolth Asger 
Published: May 2024

Abstract
Somatic mutations in cancer can be viewed as a mixture distribution of several mutational signatures, which can be inferred using non-negative matrix factorization (NMF). Mutational signatures have previously been parametrized using either simple mono-nucleotide interaction models or general tri-nucleotide interaction models. We describe a flexible and novel framework for identifying biologically plausible parametrizations of mutational signatures, and in particular for estimating di-nucleotide interaction models. Our novel estimation procedure is based on the expectation–maximization (EM) algorithm and regression in the log-linear quasi–Poisson model. We show that di-nucleotide interaction signatures are statistically stable and sufficiently complex to fit the mutational patterns. Di-nucleotide interaction signatures often strike the right balance between appropriately fitting the data and avoiding over-fitting. They provide a better fit to data and are biologically more plausible than mono-nucleotide interaction signatures, and the parametrization is more stable than the parameter-rich tri-nucleotide interaction signatures. We illustrate our framework in a large simulation study where we compare to state of the art methods, and show results for three data sets of somatic mutation counts from patients with cancer in the breast, Liver and urinary tract.
Politische Konflikte in der Sozialpolitik zwischen 2017–2021 in Deutschland: Eine Inhaltsanalyse von Plenardokumenten und Pressemitteilungen
Authors: Bender Benedikt , Malsch Laura 
Published: May 2024

Zusammenfassung
Die Studie erweitert die Forschung zur Unterstützung sozialpolitischer Reformen bei Parteien, Gewerkschaften und Arbeitgeberverbänden. Wir zeigen, dass kompensatorische Maßnahmen die klassischen Konflikte zwischen rechts und links sowie Arbeit und Kapital widerspiegeln. Sozialinvestitionen zeigen hingegen klassenübergreifende Befürwortung; außer bei der AfD, die sich gegen eine breite Unterstützung zu Gleichstellungsmaßnahmen am Arbeitsplatz positioniert. Die Ergebnisse basieren auf einer systematisch qualitativen Inhaltsanalyse von 21 Plenarprotokollen und 323 Pressemitteilungen zwischen 2017 und 2021 (19. Legislaturperiode). Der Beitrag trägt zum einen dazu bei, die konzeptuelle Relevanz der Unterscheidung zwischen kompensatorischer und sozialinvestiver Sozialpolitik zu verdeutlichen. Zum anderen zeigen wir, dass es sich trotz unterschiedlicher Zielvorstellungen der Akteure bei den Sozialinvestitionen um ein überwiegend – wenn auch nicht völlig – konfliktfreies Politikfeld handelt. Dies trägt zur Erklärung des kontinuierlichen Ausbaus von Sozialinvestitionen bei und kann auch als Prognose für eine zukünftig, sozialinvestive Entwicklung in Deutschland betrachtet werden.
The journey of the initiate towards salvation and the trials of Mithras seen through the experience of Hercules and the protection of Mithras, Hercules, and Caelestis: labors and salvation
Authors: Martini Carbone Annarita 
Published: May 2024

AbstractThis intervention focuses on the close relationship that links Mithras to Hercules, witnessed by the presence of the image of Hercules in some mithraic caves, on ritual vessels and in other contexts related to Zoroastrian Mithraism, such as the funerary monument of Antiochus I of Commagene at Nemrut Dağı.Likewise, even the veneration of the goddess Caelestis by some followers of Mithras is testified by the representation of the symbol pro itu et reditu in contexts referable to the cult of Mithras.
Preclinical assessment of a recombinant RBD-Fc fusion protein as SARS-CoV-2 candidate vaccine
Authors: Dashti Navid , Golsaz-Shirazi Forough , Soltanghoraee Haleh , Zarnani Amir-Hassan , Mohammadi Mehdi , Imani Danyal , Jeddi-Tehrani Mahmood , Amiri Mohammad Mehdi , Shokri Fazel 
Published: May 2024

AbstractBackgroundWaning immunity and emergence of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), highlight the need for further research in vaccine development.MethodsA recombinant fusion protein containing the receptor-binding domain (RBD) fused to the human IgG1 Fc (RBD-Fc) was produced in CHO-K1 cells. RBD-Fc was emulsified with four adjuvants to evaluate its immunogenicity. The RBD-specific humoral and cellular immune responses were assessed by ELISA. The virus neutralizing potency of the vaccine was investigated using four neutralization methods. Safety was studied in mice and rabbits, and Antibody-Dependent Enhancement (ADE) effects were investigated by flow cytometry.ResultsRBD-Fc emulsified in Alum induced a high titer of anti-RBD antibodies with remarkable efficacy in neutralizing both pseudotyped and live SARS-CoV-2 Delta variant. The neutralization potency dropped significantly in response to the Omicron variant. RBD-Fc induced both TH2 and particularly TH1 immune responses. Histopathologic examinations demonstrated no substantial pathologic changes in different organs. No changes in serum biochemical and hematologic parameters were observed. ADE effect was not observed following immunization with RBD-Fc.ConclusionRBD-Fc elicits highly robust neutralizing antibodies and cellular immune responses, with no adverse effects. Therefore, it could be considered a promising and safe subunit vaccine against SARS-CoV-2.
Typical Atrial Flutter in acute coronary syndrome with ST segment elevation: incidence, predictive factors and related mortality.
Authors: ZOUZOU Hanane 
Published: May 2024

Background: Typical Atrial Flutter in acute coronary syndrome with ST segment elevation is very rare and never reported as a separate electrocardiographic entity, but associated with atrial fibrillation.
Its incidence isn’t reported in the literature, and no data about its predictive factors or related mortality, also its epidemiological data is lacking in Algeria.
Aims: The main objective of our study is the determination of the frequency of typical atrial flutter in acute coronary syndrome with ST segment elevation, the secondary objective was the analysis of its predictive factors, and related mortality.
Methods and materials: In this prospective study, conducted in the cardiology department of Hussein Dey hospital (Algiers-Algeria), 467 patients with acute coronary syndrome with elevated ST segment (87 women and 380 men) were enrolled between 28 February 2014 and 16 July 2015. The average age is 60 ± 13 years; at admission, a Holter recorder was attached for continuous ECG monitoring during 48 hours
Kruskal’s ANNOVA or H tests were used for comparison of quantitative variables, χ2 test or Fisher’s exact test, were used for qualitative variables, all tests were performed with 1st species risk of 5%.
Results: The frequency of typical atrial flutter is 0.4 % (2 patients), CI 95%: [0%-1%], multivariate analysis identified right heart failure as the only predictive factor.
The risk of mortality expressed by Hazard Ration (HR) is 27 (CI95%: [3.5-207], p = 0.001); right heart failure is the only predictive factor of mortality identified in our study.
Conclusion: typical atrial flutter is very rare in acute coronary syndrome with elevated ST segment, its predictive factor according to our study is right heart failure, and its occurrence increases the risk of hospital mortality.
Design Guidelines
Authors: Saini Puneet , Weiss Wolfgang 
Published: May 2024

This document is the final report for activity B2 “Design guidelines” of the IEA SHC Task 65 “Solar Cooling for the Sunbelt regions”. It presents the collection of design and system integration guidelines for solar cooling projects. For this purpose, a comprehensive questionnaire was created that goes into detail about various solar cooling components, design, sizing and other sub-systems such as heat rejection unit and cold distribution system. Data from 10 case studies are collected and presented showing the performance of solar cooling systems with varying boundary conditions. Additionally, three different case studies, each with their own scope and unique characteristics, are discussed.
The Portrayal of Women Oppression in Reid’s The Seven Husbands of Evelyn Hugo
Authors: Damayanti Alfina Putri 
Published: May 2024

In this modern world, the phenomenon of women oppression has become more prevalent in society. Oppression against women has been embedded for generations and can really happen under any circumstances. However, this phenomenon is not only actualized in real life but is also portrayed in Taylor Jenkins Reid’s work entitled The Seven Husbands of Evelyn Hugo. The aims of this study are divided into two categories: first, to identify forms of oppression experienced by women characters, Monique Grant and Evelyn Hugo, and second, to describe women characters' struggle against oppression in the novel. The approach used in this study is the sociology of literature since the novel brings up social life issues such as inequalities based on class, race, gender, and other aspects, which these issues might be examined through the perspective of liberal feminism. Additionally, the researcher uses the ‘Five Faces of Oppression’ theory by Irish Marion Young to identify forms of oppression. The results of this study revealed that Monique and Evelyn experienced oppression due to their gender and racial background. Monique was marginalized in the workplace, whereas Evelyn was subjected to the five faces of oppression mentioned by Young, both in the private and public spheres. However, despite the oppression that Monique and Evelyn experienced, they were struggling for their freedom and rights in order to take control of their own lives and careers. Their struggles are intertwined with liberal feminism, a theory that advocates for changing laws, policies, and institutions in order to eliminate gender equality in all aspects of life.
Marginalization, Technology Access and Study Approaches of Undergraduate Distance Learners during Covid-19 Pandemic in India
Authors: Sanwal Anju 
Published: May 2024

The Covid-19 pandemic, for the past years, had led to disruption of classroom activities and adoption of online teaching-learning in almost all parts of the globe, including India. Sudden switch over from the classroom blackboard to the laptop screen may have influenced study approaches of students especially when there were challenges for access to technology and non-readiness for online learning among the Indian students. Since different social and economic factors bring differences in students’ learning, an online survey was conducted with 296 randomly selected undergraduate distance learning (DL) students of Indira Gandhi National Open University (IGNOU) to examine how technology access during the pandemic has influenced study approach of Indian DL students belonging to different marginalized and non-marginalized groups. The research results showed that marginalized students had lower access to technology than their non-marginalized counterparts, although no gender differences were found in access to technology in both the groups. Lower access to technology was found associated with more surface approach to study in the DL students in general and the marginalized students in particular. The marginalized females were found at risk in terms of both, access to technology and approaches to study. The findings, as discussed, are intended to further enrich our understanding of the role of technology vis-à-vis study approach of distance learning students during the pandemic, and formulate appropriate teaching-learning strategies for the future.
RESPON TUAN GURU DI LOMBOK BARAT TERHADAP HUKUM BERISTIDLAL DENGAN KISAH ISRAILIYAT DALAM MENAFSIRKAN AL-QUR’AN
Authors: Usman Usman , Lubna Lubna 
Published: May 2024

Abstract: Israiliyyat is a story originating from the Ahl al-Kitab literature sourced from Jews and Christians. In the Qur'an there are many stories of the Prophets and ancient people, but the mention of the story is only globally, and raises some further questions. The stories of israiliyyat are included in the interpretation of the Qur'an. This article aims to elaborate on the views of the Tuan Guru in West Lombok relating to the legal usage of the Israiliyat story in interpreting the Qur'an. This article is the result of field research with a qualitative approach using interviews, observation, triangulation, inductive and deductive methods as well as data analysis. This study succeeded in classifying two views of Tuan Guru, namely groups that are pro and contra. First, the group that accepts carefully with the reason for the existence of a series of way to accept the Isra'ilyyat story is not validated among the ulama. Secondly, the group that refused firmly the application of the story of Israel 'ilyyat. The response of Tuan Guru West Lombok to the pros and cons of using the Isra'iliyyat story is a natural thing considering the various factors and backgrounds that surround it.
Abstrak: Israiliyat merupakan kisah yang bersumber dari literatur Ahl al-Kitab yang bersumber dari orang Yahudi dan Nashrani. Dalam al-Qur’an terdapat banyak kisah para Nabi dan umat terdahulu, namun penyebutan kisah tersebut hanya secara global, dan menimbulkan pertanyaan bagi sahabat, sehingga sebagian mereka menanyakan kepada Ahl al-Kitab.Dari sinilah kisah-kisah israiliyyat masuk dalam penafsiran al-Qur’an.Artikel ini bertujuan untuk mengelaborasi pandangan para Tuan Guru di Lombok Barat berkaitan dengan hukum beristidlal menggunakan kisah Israiliyat dalam menafsirkan al-Qur’an.Artikel ini merupakan hasil penelitian lapangan dengan pendekatan kualitatif dengan menggunakan metode wawancara, observasi, triangulasi, induktif dan deduktif sekaligus dalam analisis data.Penelitian ini berhasil mengklasifikasikan dua pandangan Tuan Guru, yaitu kelompok yang pro dan yang kontra. Pertama, kelompok yang menerima dengan penuh kehati-hatian dengan alasan adanya rentetan sanad atau jalan diterimanya kisah Isra’iliyyat itu tidak dipertentangkan kesahihannya di kalangan para ulama.Kedua, kelompok yang menolak dengan tegas beristidlal menggunakan kisah isra’iliyyat.Respon Tuan Guru Lombok Barat terhadap pro-kontra penggunaan kisah Isra’iliyyat adalah hal yang wajar mengingat berbagai faktor dan latar belakang yang melingkupinya.