bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chromosomal mapping of rDNAs and H3 histone sequences in the grasshopper rhammatocerus brasiliensis (acrididae, gomphocerinae): extensive chromosomal dispersion and co-localization of 5S rDNA/H3 histone clusters in the A complement and B chromosome
Authors: Oliveira Nathalia L , Cabral-de-Mello Diogo C , Rocha Marília F , Loreto Vilma , Martins Cesar , Moura Rita C 
Published: December 2011

Abstract

Background
Supernumerary B chromosomes occur in addition to standard karyotype and have been described in about 15% of eukaryotes, being the repetitive DNAs the major component of these chromosomes, including in some cases the presence of multigene families. To advance in the understanding of chromosomal organization of multigene families and B chromosome structure and evolution, the distribution of rRNA and H3 histone genes were analyzed in the standard karyotype and B chromosome of three populations of the grasshopper Rhammatocerus brasiliensis.

Results
The location of major rDNA was coincident with the previous analysis for this species. On the other hand, the 5S rDNA mapped in almost all chromosomes of the standard complement (except in the pair 11) and in the B chromosome, showing a distinct result from other populations previously analyzed. Besides the spreading of 5S rDNA in the genome of R. brasiliensis it was also observed multiple sites for H3 histone genes, being located in the same chromosomal regions of 5S rDNAs, including the presence of the H3 gene in the B chromosome.

Conclusions
Due to the intense spreading of 5S rRNA and H3 histone genes in the genome of R. brasiliensis, their chromosomal distribution was not informative in the clarification of the origin of B elements. Our results indicate a linked organization for the 5S rRNA and H3 histone multigene families investigated in R. brasiliensis, reinforcing previous data concerning the association of both genes in some insect groups. The present findings contribute to understanding the organization/evolution of multigene families in the insect genomes.
The Role of Autoantibodies to Zinc Transporter 8 in Prediction of Type 1 Diabetes in Relatives: Lessons from the European Nicotinamide Diabetes Intervention Trial (ENDIT) Cohort
Authors: Long Anna E. , Gooneratne A. Talia , Rokni Saba , Williams Alistair J. K. , Bingley Polly J. 
Published: December 2011

Context:
Antibodies to islet autoantigens are detectable many years before clinical onset of type 1 diabetes and can be used to identify individuals at increased risk of diabetes. Zinc transporter 8 is a recently identified islet autoantigen.

Objective:
Our aim was to determine whether addition of zinc transporter 8 autoantibodies (ZnT8A) improved prediction of type 1 diabetes in a well-characterized cohort of islet cell antibody (ICA)-positive first-degree relatives. We were particularly interested in the role of ZnT8A in prediction in antibody-positive relatives with intermediate and low overall risk of diabetes.

Participants and Methods:
ZnT8A were assayed in baseline samples from 526 ICA-positive first-degree relatives randomized in the European Nicotinamide Diabetes Intervention Trial. Antibodies to insulin, glutamate decarboxylase, islet antigen-2 (IA-2A) and IA-2β (IA-2βA), and human leukocyte antigen type had been previously determined. Risk of diabetes was assessed by survival analysis.

Results:
Of 221 ZnT8A-positive individuals, 113 developed diabetes during follow-up (5-yr cumulative risk, 55%). In multivariate models based on other autoantibodies, ZnT8A improved prediction in relatives at low genetic risk of diabetes (P = 0.030) and over age 20 yr (P = 0.026), but not in those with ICA alone or with one additional autoantibody (P = 0.696), IA-2A-negative relatives (P = 0.361), those at high or intermediate genetic risk, or younger relatives.

Conclusions:
ZnT8A are useful additional risk markers in relatives at low genetic risk of diabetes and older individuals, but they add relatively little in younger populations because of the precise prediction possible with current autoantibody combinations.
Improved infarction rates in fibroids after the introduction of contrast-enhanced ultrasound during uterine artery embolization
Authors: Dorenberg Eric J , Hol Per-Kristian , Jakobsen Jarl Å , Ring Eva 
Published: December 2011

Background In order to achieve sustained symptom control and minimize the risk of recurrence, uterine artery embolization (UAE) should aim at complete infarction of all fibroids. Purpose To retrospectively evaluate the infarction rate of uterine fibroids in patients that had undergone uterine artery embolization (UAE) after the introduction of contrast-enhanced ultrasound (CEUS) during UAE procedures at our institution. Material and Methods Thirty patients treated with UAE between February 2006 and August 2009 were included. MR images obtained before, at 3 months, and 12 months after the procedure were reviewed. We evaluated volume changes in dominant fibroids as well as the infarction rate of all fibroids in each patient. Clinical results were evaluated by reviewing the medical records. The study was approved by the institutional review board. Results CEUS was technically successfully performed during the UAE procedure in all patients. In five cases the endpoint of embolization was adjusted based on findings at CEUS. The mean volume shrinkage of dominant fibroids was 39.8% after 3 months and 59.8% after 12 months. There was complete infarction of all fibroid tissue in 97% of patients at 3 months and 96% at 12 months. No major complications were observed. Conclusion After the introduction of CEUS during UAE procedures in our institution, high infarction rates were achieved.
The case for early treatment of dislocations of the cervical spine with cord involvement sustained playing rugby
Authors: Newton D. , England M. , Doll H. , Gardner B. P. 
Published: December 2011

The most common injury in rugby resulting in spinal cord injury (SCI) is cervical facet dislocation. We report on the outcome of a series of 57 patients with acute SCI and facet dislocation sustained when playing rugby and treated by reduction between 1988 and 2000 in Conradie Hospital, Cape Town. A total of 32 patients were completely paralysed at the time of reduction. Of these 32, eight were reduced within four hours of injury and five of them made a full recovery. Of the remaining 24 who were reduced after four hours of injury, none made a full recovery and only one made a partial recovery that was useful. Our results suggest that low-velocity trauma causing SCI, such as might occur in a rugby accident, presents an opportunity for secondary prevention of permanent SCI. In these cases the permanent damage appears to result from secondary injury, rather than primary mechanical spinal cord damage. In common with other central nervous system injuries where ischaemia determines the outcome, the time from injury to reduction, and hence reperfusion, is probably important. In order to prevent permanent neurological damage after rugby injuries, cervical facet dislocations should probably be reduced within four hours of injury.
Circulating Troponin As Measured by a Sensitive Assay for Cardiovascular Risk Assessment in Primary Prevention
Authors: Leistner David M , Klotsche Jens , Pieper Lars , Stalla Günter K , Lehnert Hendrik , Silber Sigmund , März Winfried , Wittchen Hans-Ulrich ,   for the DETECT Study Group, Zeiher Andreas M 
Published: December 2011

Abstract

BACKGROUND
Measuring circulating cardiac troponin using novel sensitive assays has revealed that even minute elevations are associated with increased mortality in patients with coronary artery disease or even in the general population. Less well defined, however, is the incremental value of measuring circulating cardiac troponin I (cTnI) by a sensitive assay for risk assessment in primary prevention.

METHODS
We measured circulating concentrations of cTnI, N-terminal pro–B-type natriuretic peptide (NT-proBNP), and high-sensitivity C-reactive protein (hsCRP) in 5388 individuals free of known cardiovascular disease recruited into the DETECT study, a prospective longitudinal population-based cohort study. We determined the prognostic implications for incident major adverse cardiovascular events (MACE) during 5 years of follow-up.

RESULTS
Circulating cTnI was detectable in 19% of the subjects. Increased cTnI concentrations were associated with established risk factors for atherosclerosis and demonstrated a graded relationship with all-cause mortality and incident MACE during 5-year follow-up. A single measurement of cTnI significantly improved risk prediction over established risk factors, and also added prognostic information, when adjusted for serum concentrations of NT-proBNP and hsCRP.

CONCLUSIONS
Minute increases in cTnI are associated with increased mortality and incident MACE in a large primary prevention cohort and, thus, identify contributors to cardiovascular risk not fully captured by traditional risk factor assessment.
Evaluation of An Australian Day Treatment Program for Eating Disorders
Authors: Nowoweiski Dion , Arthey Stephen , Bosanac Peter 
Published: December 2011

AbstractDay treatment programs (DTP) for eating disorders are being recognised as having therapeutic benefits. However, research is needed to evaluate the effectiveness of DTP to establish their validity. This article reports on the evaluation of a pilot DTP in an Australian mental health setting, which utilised an integrative approach combining evidence-based treatments such as dialectical-behavioural therapy and intensive short-term dynamic psychotherapy offered in a group-based setting. Comparison of pre- and post-treatment data outcome measures for eating disorder pathology and comorbid symptoms was undertaken. Patient satisfaction was also evaluated using qualitative methods. Results indicated a significant reduction in depressive symptoms post-treatment, along with a high degree of satisfaction with the treatment. Limitations of this study, along with the implications of the findings and directions for future research, are discussed.
A Population-Based Evaluation of the Intention to Quit Smoking, Cervical Cancer Screening Behaviour, and Multiple Health Behaviours Among Female Canadian Smokers
Authors: Falasinnu Titilola O. 
Published: December 2011

AbstractIntroduction:Proschaska's transtheoretical model (TTM) of behaviour change suggests that a population of smokers varies along many dimensions, including readiness to quit and the presence of other risk factors. This study examines whether smokers contemplating quitting are more likely to be contemplating another change (e.g., Pap testing and physical activity).Methods:The study used self-reported cross-sectional data (n= 2,873) from the Canadian Community Health Survey (CCHS) Cycle 4.1 2007/2008. The association between the smoking stage of change (SOC) and Pap testing behaviour was assessed. Control variables included sociodemographic and behavioural characteristics (e.g. doctor visits and number of cigarettes smoked). The distribution of health behaviours (e.g., dietary changes and exercise) by smoking SOC among women with recent Pap tests was also examined.Results:Female smokers contemplating or preparing to quit smoking had higher odds of having a recent Pap test, OR = 1.40, 95% CI (1.19, 1.65), and OR = 1.82, 95% CI (1.47, 2.25) respectively, compared to smokers who had no intention of quitting. This association remained statistically significant after adjusting for confounders, AOR = 1.28, 95% CI (1.08, 1.52), and AOR = 1.63, 95% CI (1.31, 2.04) respectively. Fruit and vegetable consumption, physical activity, and recent dental visit were associated with advanced smoking SOC among women with recent Pap tests (P< .05).Conclusions:Advanced smoking SOC was associated with the increased likelihood of having a recent Pap test and engaging in other healthy behaviours. These findings show that targeting several health behaviours simultaneously may be an effective health promotion strategy.
Cognitive Appraisals and Smoking Intentions: The Role of Decision Making Competence
Authors: Umeh Kanayo , Barnes Jennifer 
Published: December 2011

AbstractAn important element of smoking cessation programs is the modification of health beliefs about risks and benefits. However, Janis and Mann's (1977) conflict-theory suggests only vigilant decision-makers are motivated by such outcome appraisals. Thus, this study examined the extent to which relations between health beliefs and cigarette smoking are moderated by decision-making competence. Over 150 university undergraduates completed a questionnaire survey assessing health beliefs about smoking (perceptions of susceptibility to and severity of lung cancer, and benefits of not smoking), smoking intentions, and decision-making competence. Hierarchical regression analysis revealed interactions between risk perceptions and competence, whereby perceived susceptibility and severity appraisals better predicted smoking intentions in less proficient decision-makers. However, these interactions disappeared after controlling for smoking status. These findings suggest that risk perceptions are more important in college students averse to information search and appraisal, albeit this is confounded by smoking status.
Evaluation of Graphic Cigarette Warning Images on Cravings to Smoke
Authors: Lin Patrick N. , Zimmermann Mia Hanos , Bover Manderski Michelle T. , Schmelzer Amy C. , Steinberg Michael B. 
Published: December 2011

AbstractWhile health warnings are present on cigarette packs around the world, the nature of the warnings varies considerably between countries. In the United States, a small text warning citing the dangers of cigarette smoking is found on the side of all packs. This pilot study sought to determine whether graphic cigarette warning images, like those found in the United Kingdom and Canada, were better at decreasing cravings to smoke than existing text warnings found on cigarette packs in the United States. Twenty-five smokers seeking treatment to quit at a specialty tobacco treatment program were administered the Brief Questionnaire of Smoking Urges (QSU — BRIEF), a validated measure of craving, prior to and following exposure to cigarette pack warning images. The graphic cigarette warning images reduced cravings to smoke (6.20 point decrease) more than neutral images (3.36 point decrease) and current text warnings used in the United States (5.75 point decrease), although this difference was not statistically significant. Based on these pilot data, a larger study could further examine the effectiveness of graphic warning images and whether such warnings hold an advantage over the currently used text warnings.
A Theoretical Explanation of Male Partner Participation in Smoking Cessation during the Transition to Fatherhood
Authors: Gage Jeffrey D. , Everett Kevin D. , Bullock Linda 
Published: December 2011

AbstractThe purpose of this study was to develop a theoretical explanation of the process of becoming a father and how this impacted on smoking behaviours of men during their partner's pregnancy. Grounded theory method and constant comparative analysis was used to explain data from interviews with 23 men from rural Midwest USA. Becoming a father prompted participants to seek ways to protect their partners and babies from the effects of cigarette smoking. First-time fathers were particularly receptive to quitting smoking early in their partner's pregnancy, whereas motivation to quit declined as pregnancy progressed for first-time fathers and other fathers. Although protecting their families from cigarette smoke remained constant, men's smoking goals and behaviours became increasingly focused on minimising harm rather than quitting as their partner's pregnancy progressed. Findings support the view that the transition to fatherhood is an opportune time in which to encourage and support smoking behaviour change for male partners. Theoretical insights provide understanding of why and when expectant fathers attempt to quit smoking and reduce harm to their families. Future research should focus on appropriate and timely interventions to maximise the success of men to quit smoking when they are naturally motivated to do so.
Roller Profile Development for an Axially Loaded, Single Row Spherical Roller Bearing in an Oscillating Application
Authors: Cowles J. H. , Houle C. A. 
Published: December 2011

Abstract
Typically it is not recommended to use a single row spherical roller bearing in an application in which there are significant axial loads. The use of these bearings in a less than optimal customer application can be driven by the need for a high load capacity within a limited geometric envelope. Specialized roller profiles can be developed that eliminate high contact stresses on the roller ends that can lead to the premature failure of the bearing. In this paper, analytical results are presented for the roller to raceway contact stress of four different roller profiles with a given load applied to the bearing. The profiles considered are single transverse radius, double transverse radii, and optimized symmetric and asymmetric. The piecewise logarithmic profiles developed are applied to a barrel roller in this paper, but a generalized method is developed such that the profile could be applied to any type of roller—cylindrical, barrel, hourglass, or tapered. The analysis results for two of the profiles are validated by dynamic testing performed within RBC’s Corporate Test Laboratory on a three axis, hydraulic, computer controlled test rig. The bearing inner ring is oscillated while the bearing is subjected to simultaneous radial and axial loads. The control software allows the monitoring of radial displacement and bearing torque during testing. The test results correlate very well with the analytical results. The displacement and torque readouts are shown to predict the onset of raceway fatigue and spalling for one of the roller configurations before testing is complete and the bearing is disassembled.
Cytokine Levels as Potential Biomarkers for Predicting the Development of Posttraumatic Stress Symptoms in Casualties of Accidents
Authors: Cohen Miri , Meir Tamar , Klein Ehud , Volpin Gershon , Assaf Michael , Pollack Shimon 
Published: December 2011

Background: Traumatic injuries are usually associated with increased secretion of pro-inflammatory cytokines, and are sometimes followed by the development of acute stress symptoms (ASS) and posttraumatic stress symptoms (PTSS). Aims: To measure serum pro- and anti-inflammatory cytokines in accident casualties and to associate it with ASS at hospitalization, and with PTSS 1 month later. Methods: Participants were 48 patients, aged 20–60, hospitalized following various orthopedic injuries including bone fractures, and 13 healthy volunteers matched for gender. At hospitalization (Time 1), 30 ml heparinized venous blood were drawn and cytokines levels in serum were assessed; participants filled out the Acute Stress Disorder Inventory (ASDI), COPE, and injury-related questionnaires. One month later (Time 2), 26 participants filled out the Posttraumatic Disorder Symptom Scale (PDS). Results: High serum levels of IL-6, IL-8, and TGF-β and low levels of serum IL-4 and IL-10 were found in injured patients as compared with controls. When controlling for age and severity of injury in the regression analysis, higher levels of IL-6 and IL-8 and lower TGF-β were predicted by higher ASS and higher use of and emotion-focused coping. Higher PTSS scores at Time 2 were predicted by higher levels of IL-8, lower levels of TGF-β, and higher ASS measured at Time 1. Conclusions: High levels of the pro-inflammatory cytokine IL-6 and IL-8 and lower levels of the regulatory cytokine TGF-β should be further assessed as a possible risk factor or a bio-marker of PTSS in accident casualties.
Impacts of Mycoplasma gallisepticum Vaccine on Newcastle Disease Vaccination and Protection in Parent Stock Flocks
Authors: Faruque M Rayhan , Christensen Jens P 
Published: December 2011

The present study reports on the impact of Mycoplasma gallisepticum (MG) vaccination on vaccine respond and subsequent protection against Newcastle disease (ND) in parent stock flocks of Department of Livestock Services (DLS) using MG killed vaccine and conventional ND vaccines. Birds were grouped into four groups, each consisted of 50 birds from the same flock. Group A birds were vaccinated with ND, group B with ND and MG, group C with MG, and group D birds were kept as unvaccinated control. The parameters studied included detection of ND antibody, MG seroprevalance, mortality (%), and cause of death. The sera of groups B and C were sero-positive after administration of MG vaccine. The haemagglutination-inhibition (HI) titres of group A were higher than group B from week 4 after administration of MG vaccine to the birds of group B. The mortality was very low; one bird of group C died at week 5 due to traumatic injury and another bird of group D died at week 2 due to infectious bronchitis virus (IBV). After challenge, birds of groups A and B showed no clinical signs and normal post mortem findings were found. Birds of groups C and D showed clinical signs from day 3 and different pathological lesions were found in post mortem. The MG vaccination did not improve other parameters. Therefore, inoculation of MG INAC vaccine is not justified and is too expensive at farm levels.Keywords: Mycoplasma gallisepticum (MG) vaccine, Newcastle disease (ND) vaccination, Protection, MortalityDOI: http://dx.doi.org/10.3329/bjm.v24i1.1240 Bangladesh J Microbiol, Volume 24, Number 1, June 2007, pp 62-64
Bilateral hypoplasia of the internal carotid artery
Authors: Bhat Dhananjaya I , Somanna Sampath , Kovoor Jerry ME 
Published: December 2011

AbstractAgenesis and hypoplasia of the internal carotid artery (ICA) are rare congenital anomalies, occurring in less than 0.01% of the population. We report a rare case of bilateral hypoplasia of the ICA in a patient with post-traumatic subarachnoid hemorrhage. We describe the embryological development of the cerebral vasculature and present a review of literature.
Presacral hibernoma: Radiologic-pathologic correlation
Authors: Pandya Amit , Wasnik Ashish P 
Published: December 2011

AbstractHibernoma is a rare benign tumor of brown fat origin. It is found in locations where brown adipose tissue is present in the fetus. These locations include the neck, axilla, thorax, and extremities. Retroperitoneal hibernoma is an extremely rare site of presentation. We present a rare case of presacral hibernoma. Preoperative embolization of this highly vascular tumor was performed. To the best of our knowledge, this is the first reported case of a presacral hibernoma in the English literature.