bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Unprecedented ipso Aromatic Nucleophilic Substitution upon Oxidative Decarboxylation of Tris(p‐carboxytetrathiaaryl)methyl (TAM) Radicals: A New Access to Diversely Substituted TAM Radicals.
Authors: Decroos Christophe , Prange Thierry , Mansuy Daniel , Boucher Jean‐Luc , Li Yun 
Published: August 2011

AbstractWhereas nucleophiles (II) and (IV) and (VI) only afford the mono‐substitution products (III) and (V), respectively, under identical reaction conditions NaNO2 gives rise to the formation of the corresponding tri‐nitro TAM radical (VII).
ChemInform Abstract: One Pot Spiropyrazoline Synthesis via Intramolecular Cyclization/Methylation.
Authors: Dadiboyena Sureshbabu , Hamme Ashton T. II 
Published: August 2011

Abstract1,3‐Dipolar cycloaddition of alkenes (I) or (VII) with a nitrile imine derived from hydrazinoyl chloride (II) gives products (III) and (VIII).
ChemInform Abstract: Intramolecular Diels—Alder Chemistry of 4‐Vinylimidazoles.
Authors: He Yong , Krishnamoorthy Pasupathy , Lima Heather M. , Chen Yingzhong , Wu Haiyan , Sivappa Rasapalli , Dias H. V. Rasika , Lovely Carl J. 
Published: August 2011

AbstractThe intramolecular Diels—Alder cycloaddition of amide‐, ester‐ or ether‐tethered dienylimidazoles is studied concerning the influence of the nature of tether and N‐protecting groups.
ChemInform Abstract: Stereodivergent Direct Catalytic Asymmetric Mannich‐Type Reactions of α‐Isothiocyanato Ester with Ketimines.
Authors: Lu Gang , Yoshino Tatsuhiko , Morimoto Hiroyuki , Matsunaga Shigeki , Shibasaki Masakatsu 
Published: August 2011

AbstractThe reaction results in formation of thioxoimidazolidines as a mixture of diastereoisomers.
ChemInform Abstract: Combining Gold(I)/Gold(III) Catalysis and C—H Functionalization: A Formal Intramolecular [3 + 2] Annulation Towards Tricyclic Indolines and Mechanistic Studies.
Authors: Zhang Guozhu , Luo Yingdong , Wang Yanzhao , Zhang Liming 
Published: August 2011

AbstractTricyclic indolines are obtained by the present new intramolecular [3+2] annulation between a vinyl group and an aniline moiety using Selectfluor as oxidant.
ChemInform Abstract: Samarium Iodobinaphtholate: An Efficient Catalyst for Enantioselective Aza‐Michael Additions of O‐Benzylhydroxylamine to N‐Alkenoyloxazolidinones.
Authors: Didier Dorian , Meddour Abdelkrim , Bezzenine‐Lafollee Sophie , Collin Jacqueline 
Published: August 2011

AbstractThe title axially chiral samarium compound selectively catalyzes the formation of aza‐Michael adducts with up to 88% enantioselectivity.
ChemInform Abstract: One‐Pot Regioselective Synthesis of 3‐Benzylthiazolo[3,2‐a]indoles by Sequential Sonogashira Coupling Followed by Triethylamine‐Induced Cyclization.
Authors: Majumdar K. C. , Nath Sanjay 
Published: August 2011

AbstractA regioselective method for the synthesis of the title compounds such as (III) and (V) is developed.
ChemInform Abstract: Synthesis of 2‐Thio‐Substituted Benzothiazoles via a Domino Condensation/S‐Arylation/Heterocyclization Process.
Authors: Shi Liu , Liu Xiangqian , Zhang Hui , Jiang Yongwen , Ma Dawei 
Published: August 2011

AbstractIt provides a facile method to prepare a wide range of 2‐thio‐substituted benzothiazoles.
ChemInform Abstract: Halogenation Reagents Initiating Ring Opening of Vinylidenecyclopropanes: Easy Access to Halogenated Tetrahydropyrans.
Authors: Yuan Wei , Shi Min 
Published: August 2011

AbstractHalogenation reagents initiate intramolecular ring‐opening reactions of diarylvinylidenecyclopropanes tethered to an alcohol‐bearing chain, to afford a variety of halogenated tetrahydropyrans in moderate to good yields under mild conditions.
ChemInform Abstract: Ph3PAuNTf2 as a Superior Catalyst for the Selective Synthesis of 2H‐Chromenes: Application to the Concise Synthesis of Benzopyran Natural Products.
Authors: Lykakis Ioannis N. , Efe Christina , Gryparis Charis , Stratakis Manolis 
Published: August 2011

AbstractCycloisomerization of aryl propargyl ethers efficiently proceeds, in the presence of [Au(PPh3)]NTf2 as catalyst to give benzopyrans, e.g. (III) in high chemoselectivity.
ChemInform Abstract: A Novel Sulfonic Acid Functionalized Ionic Liquid Catalyzed Multicomponent Synthesis of 10,11‐Dihydrochromeno[4,3‐b]chromene‐6,8(7H,9H)‐dione Derivatives in Water.
Authors: Chen Zhiwei , Zhu Qiang , Su Weike 
Published: August 2011

AbstractAdvantages of the process are simple reaction conditions and reusability of the ionic liquid.
ChemInform Abstract: Lewis Base Catalyzed [4 + 2] Annulation of Electron‐Deficient Chromone‐Derived Heterodienes and Acetylenes.
Authors: Dueckert Heiko , Khedkar Vivek , Waldmann Herbert , Kumar Kamal 
Published: August 2011

AbstractElectron‐deficient chromone heterodienes and electron‐poor acetylenes undergo Lewis base catalyzed [4+2] annulation reactions.
ChemInform Abstract: Organocatalytic Enantioselective Multicomponent Cascade Reaction: Facile Access to Tetrahydropyridines with C3 All‐Carbon Quaternary Stereocenters.
Authors: Yu De‐Feng , Wang Yao , Xu Peng‐Fei 
Published: August 2011

AbstractIn the course of the reaction, three C—C bonds, two C—N bonds, and an all‐carbon quaternary stereocenter are formed.
ChemInform Abstract: β‐Lactam‐Synthon‐Interceded, Facile, One‐Pot, Diastereoselective Synthesis of Functionalized Tetra/Octahydroisoquinolone Derivatives.
Authors: Raj Raghu , Mehra Vishu , Singh Pardeep , Kumar Vipan , Bhargava Gaurav , Mahajan Mohinder P. , Handa Sachin , Slaughter LeGrande M. 
Published: August 2011

Abstractβ‐Lactams (I) bearing an ester group at the 3‐position are transformed in a single step into the desired octahydroquinolones (II) by treatment with MeONa in refluxing xylene.
ChemInform Abstract: Bifunctional Primary Amine‐Thiourea—TfOH (BPAT·TfOH) as a Chiral Phase‐Transfer Catalyst: The Asymmetric Synthesis of Dihydropyrimidines.
Authors: Wang Yangyun , Yu Jipan , Miao Zhiwei , Chen Ruyu 
Published: August 2011

AbstractAsymmetric Biginelli reaction of β‐ketoester (I) with urea (II) and a range of aromatic aldehydes (III) is efficiently catalyzed by a catalyst system consisting of bifunctional glucose‐derived amine—thiourea (BPAT), tBuNH2·TFA and triflic acid.
ChemInform Abstract: Diversity Oriented Synthesis: Substitution at C5 in Unreactive Pyrimidines by Claisen Rearrangement and Reactivity in Nucleophilic Substitution at C2 and C4 in Pteridines and Pyrido[2,3‐d]pyrimidines.
Authors: Adcock Jonathan , Gibson Colin L. , Huggan Judith K. , Suckling Colin J. 
Published: August 2011

AbstractA number of diversified pyridopyrimidines and pteridines are prepared and their biological activity is screened.
ChemInform Abstract: Synthesis of N‐Aryl‐2,2,2‐trifluoroacetimidoyl Piperazinylquinolone Derivatives and Their Antibacterial Evaluations.
Authors: Darehkordi Ali , Javanmiri Mahmood , Ghazi Somayeh , Assar Shokrollah 
Published: August 2011

AbstractPiperazinylquinolone derivatives (IIIa) and (IIIb) possess good antibacterial activities against E.
ChemInform Abstract: Thiourea‐Catalyzed Organocatalytic Enantioselective Michael Addition of Diphenyl Phosphite to Nitroalkenes.
Authors: Alcaine Ana , Marques‐Lopez Eugenia , Merino Pedro , Tejero Tomas , Herrera Raquel P. 
Published: August 2011

AbstractA variety of enantioenriched β‐nitrophosphonates (III) is readily obtained by asymmetric Michael addition of diphenylphosphite (II) to nitroolefins (I) in the presence of a bifunctional amine—thiourea organocatalyst.
ChemInform Abstract: Gardenoins E—H, Cycloartane Triterpenes from the Apical Buds of Gardenia obtusifolia.
Authors: Nuanyai Thanesuan , Sappapan Ruengrit , Vilaivan Tirayut , Pudhom Khanitha 
Published: August 2011

AbstractFour new cycloartane triterpenes, named gardenoins E—H (I)—(III), are isolated from the apical buds of the title plant together with five known cycloartanes.
ChemInform Abstract: A New Diterpenoid Glucoside and Two New Diterpenoids from the Fruit of Vitex agnus‐castus.
Authors: Ono Masateru , et al. et al. 
Published: August 2011

AbstractA new labdane‐type diterpenoid glycoside (I) and two new labdane‐type diterpenoids (II) and (III) are isolated from the Monk′s Pepper fruit (chasteberry) along with 14 known di‐, tri‐ and sesquiterpenoids and one flavanoid.
ChemInform Abstract: Synthesis and Biological Evaluation of 16E‐Arylidenosteroids as Cytotoxic and Antiaromatase Agents.
Authors: Bansal Ranju , Guleria Sheetal , Thota Sridhar , Hartmann Rolf Wolfgang , Zimmer Christina 
Published: August 2011

AbstractSeveral new (16E)‐arylidenosteroidal derivatives are prepared and evaluated for their cytotoxic and aromatase inhibitory activity.
ChemInform Abstract: The Structure of a New Cardenolide Diglycoside and the Biological Activities of Eleven Cardenolide Diglycosides from Nerium oleander.
Authors: Zhao Ming , et al. et al. 
Published: August 2011

AbstractCompound (I) is isolated as new cardenolide diglycoside from Nerium oleander together with ten known structurally related diglycosides.
ChemInform Abstract: “Inosaminoacids”: Novel Inositol—Amino Acid Hybrid Structures Accessed by Microbial Arene Oxidation.
Authors: Pilgrim Sarah , Kociok‐Koehn Gabriele , Lloyd Matthew D. , Lewis Simon E. 
Published: August 2011

AbstractA concise synthetic route to a novel class of azacarbasugars, such as (VIII), (X) and (XI) is described.
ChemInform Abstract: Gold‐Catalyzed Reactions of 2‐C‐Branched Carbohydrates: Mild Glycosidations and Selective Anomerizations.
Authors: Vidadala Srinivasa Rao , Pimpalpalle Tukaram M. , Linker Torsten , Hotha Srinivas 
Published: August 2011

AbstractUnder catalysis of AuBr3, β‐glycosides (I) and (VIII) undergo anomerization to give their α‐anomers.
ChemInform Abstract: Noteworthy Observations Accompanying Synthesis of the Apoptolidin Disaccharide.
Authors: Srinivasarao Madduri , Park Taesik , Chen Yuzhong , Fuchs Philip L. 
Published: August 2011

AbstractThe disaccharide moiety (X) of apoptolidin is prepared using Hanessian—Hullar reaction of benzylidene (II), debromination of bromide (III), glycosylation of chloroacetimidate (VI) with olivomycose derivative (VII), and fluorination of alcohol (IX) as key steps.
ChemInform Abstract: Further Optimization of Detritylation in Solid‐Phase Oligodeoxyribonucleotide Synthesis.
Authors: Tram Kha , Sanghvi Yogesh S. , Yan Hongbin 
Published: August 2011

AbstractOptimized reaction conditions for the removal of dimethoxytrityl, pixyl, and dimethylpixyl protecting groups in compounds (I) are elaborated.
ChemInform Abstract: First Efficient Uncharged Reactivators for the Dephosphylation of Poisoned Human Acetylcholinesterase.
Authors: Mercey Guillaume , Verdelet Tristan , Saint‐Andre Geraldine , Gillon Emilie , Wagner Alain , Baati Rachid , Jean Ludovic , Nachon Florian , Renard Pierre‐Yves 
Published: August 2011

AbstractThe title compounds (I) are extremely promising uncharged reactivators for poisoned human AChE with a superior or similar in vitro ability to reactivate the enzyme as that of HI‐6, obidoxime, TMB‐4 and HL‐7.
ChemInform Abstract: Luminescent Silica Nanoparticles: Extending the Frontiers of Brightness
Authors: Bonacchi Sara , Genovese Damiano , Juris Riccardo , Montalti Marco , Prodi Luca , Rampazzo Enrico , Zaccheroni Nelsi 
Published: August 2011

AbstractReview: syntheses and photochemical properties of dye‐doped silica nanoparticles, systems with high brihtness for applications as luminescent or electroluminescent labels and chemosensors; 72 refs.
Vortex‐in‐cell method combined with a boundary element method for incompressible viscous flow analysis
Authors: Kim Yoo‐Chul , Suh Jung‐Chun , Lee Kyung‐Jun 
Published: August 2011

SUMMARYIn this study, an immersed boundary vortex‐in‐cell (VIC) method for simulating the incompressible flow external to two‐dimensional and three‐dimensional bodies is presented. The vorticity transport equation, which is the governing equation of the VIC method, is represented in a Lagrangian form and solved by the vortex blob representation of the flow field. In the present scheme, the treatment of convection and diffusion is based on the classical fractional step algorithm. The rotational component of the velocity is obtained by solving Poisson's equation using an FFT method on a regular Cartesian grid, and the solenoidal component is determined from solving an integral equation using the panel method for the convection term, and the diffusion term is implemented by a particle strength exchange scheme. Both the no‐slip and no‐through flow conditions associated with the surface boundary condition are satisfied by diffusing vortex sheet and distributing singularities on the body, respectively. The present method is distinguished from other methods by the use of the panel method for the enforcement of the no‐through flow condition. The panel method completes making use of the immersed boundary nature inherent in the VIC method and can be also adopted for the calculation of the pressure field. The overall process is parallelized using message passing interface to manage the extensive computational load in the three‐dimensional flow simulations. Copyright © 2011 John Wiley & Sons, Ltd.
Clay acquisition and processing strategies during the first millennium A.D. in the Thukela River basin, South Africa: An ethnoarchaeological approach
Authors: Fowler Kent D. , Fayek Mostafa , Middleton Emma 
Published: August 2011

AbstractDespite a sizable corpus of pottery provenance studies in southern Africa, there has been no systematic research aimed at comparing modern and ancient production strategies. In this paper we present a model of Zulu clay acquisition and processing strategies and outline its implications for understanding the mineralogical composition of ceramics produced by early farming communities in the Thukela River basin in South Africa. Through a comparison of the mineralogical properties of modern and archaeological ceramics from the basin, we propose that clay‐processing strategies were considerably different during the first millennium A.D., while clay acquisition strategies have not changed considerably in the basin over time. © 2011 Wiley Periodicals, Inc.
Common mechanisms of osteosarcoma and paget's disease
Authors: Hansen Marc F. , Nellissery Maggie J. , Bhatia Pardeep 
Published: August 2011

Abstract
One of the most serious complications of Paget's disease is a significant increase in the incidence of osteosarcoma. Approximately 1% of Paget's patients develop osteosarcoma, an increase in risk that is several thousand-fold higher than the general population. This risk contributes significantly to the mortality and morbidity of Paget's disease patients. We examined several cases of pagetic and sporadic osteosarcoma for tumor-specific loss of constitutional heterozygosity (LoH) on chromosome 18q. Our analysis found that both pagetic and sporadic osteosarcoma tumors showed LoH for all or part of the distal portion of chromosome 18q. The pattern of LoH in both types of tumors identified a region between loci D18S60 and D18S42 that must contain the putative tumor suppressor locus. This region is tightly linked to familial Paget disease and familial expansile osteolysis (FEO). Our hypothesis is that the predisposition locus for Paget's disease and the tumor suppressor locus for osteosarcoma are either the same gene or that osteosarcoma in Paget's disease represents a deletion affecting two adjacent genes. In either model, localization of the osteosarcoma tumor suppressor gene would be of benefit in the eventual isolation of the predisposition locus for Paget's disease. We have begun to isolate and test candidate genes from within the region defined by both the familial Paget's disease families and the minimal region of LoH in osteosarcomas for evidence that one or more of them is responsible for predisposition to Paget's disease and/or osteosarcoma.
Surgical management of neoplastic complications of paget's disease
Authors: Harrington Kevin D. 
Published: August 2011

Abstract
Pagetic sarcoma is a rare anaplastic malignancy with a peak incidence in the seventh and eighth decades of life; it usually occurs in patients with polyostotic Paget's disease. The most common tumor type is osteosarcoma. In one-third of the cases, presentation is a spontaneous pathologic fracture of an affected long bone. Amputation is the most appropriate form of surgical management in most cases because of the aggressive behavior of the sarcoma and its usually late presentation in this elderly population. However, selected patients with extremity lesions may be managed by pre- and postoperative chemotherapy and wide curative resection with limb salvage reconstruction. It is essential to differentiate pagetic sarcoma from metastatic carcinoma in pagetic bone and from a benign giant cell tumor.
Goals of treatment for paget's disease of bone
Authors: Siris Ethel S. 
Published: August 2011

Abstract
The goals of treatment of Paget's disease must be readdressed in the context of the availability of potent bisphosphonate compounds, including pamidronate and, more recently, alendronate and risedronate. These agents differ from the traditional mainstays of therapy, salmon calcitonin and etidronate, in several respects. First, they achieve a reduction in the elevated indices of pagetic bone turnover of about 80%, in contrast with the 50% reduction seen with the older agents. Second, a majority of patients (in the range of 50–75%, depending on the series) achieve biochemical remission, and the duration of remission may exceed 1 year or more after a single course of therapy. Third, with the newer bisphosphonates the quality of newly forming bone after successful treatment is lamellar in appearance (as was the case with etidronate) but there is no clinically significant mineralization abnormality associated with these more recent agents. With prior therapies, the primary goal of treatment was to relieve symptoms. In the absence of complete suppression of abnormal turnover, disease progression was not completely halted in many patients, increasing the risk of long-term complications. The characteristics of the newer agents, however, suggest that in those patients who achieve remission there is a possibility, albeit not yet proven, of arresting progression and reducing the risk of later complications. Many patients have no symptoms at presentation but have active disease at locations where progression could cause bone enlargement and deformity over time. These patients may be considered to be at increased risk of future complications if untreated. Thus, it is recommended that such individuals receive therapy with a potent bisphosphonate with the goal of attaining normal (or near normal) biochemical indices after initial treatment and/or retreatment Patients should be followed with measurement of serum alkaline phosphatase every 4–6 months after a course of therapy, and retreatment is suggested when indices rise above the upper limit of normal or by 25% above the previous nadir. The uncommon possibility of secondary resistance to a given agent after more than one treatment course should be assessed in all patients.
Factors associated with self-rated health in patients with paget's disease of bone
Authors: Gold Deborah T. , Burchett Bruce M. , Shipp Kathy M. , Pieper Carl F. , Lyles Kenneth W. 
Published: August 2011

Abstract
Multiple studies show that poor self-rated health (SRH) increases the risk of mortality up to 5-fold when compared to excellent SRH. This powerful association remains even with objective health status and risk factors controlled. However, few studies have examined the determinants of SRH, especially as they relate to specific chronic diseases. Here we identify personal characteristics and disease-related attributes that are strongly associated with SRH in a sample of patients with Paget's disease of bone to determine whether any factors can be modified. Two thousand people randomly selected from the Paget Foundation mailing list received a survey asking for information on demographics, general health and functioning, and the impact of Paget's disease. Nine hundred and fifty-eight PD patients returned the completed survey and answered the question, “How would you rate your overall health?” Answers ranged from excellent (1) to poor (5). Ordinary least squares regression was used, with SRH as the dependent variable, to identify those variables significantly associated with SRH. The overall regression model was significant (p = 0.0001; R2 = 0.44). Age (p = 0.005), satisfaction with family help (p = 0.0001), number of comorbid conditions (p = 0.0001), functional limitations (p = 0.0003), disease impact (p = 0.0002), health compared to 5 years ago (p = 0.0001), and depressive symptoms (p = 0.012) were significant predictors. Of these, satisfaction with family help, functional limitations, disease impact, and depressive symptoms are potentially modifiable with appropriate interventions. Future longitudinal studies should examine the effectiveness of such interventions in improving SRH.
Critical‐size defect induces unicompartmental osteoarthritis in a stable ovine knee
Authors: Schinhan Martina , Gruber Martin , Vavken Patrick , Dorotka Ronald , Samouh Leila , Chiari Catharina , Gruebl‐Barabas Ruth , Nehrer Stefan 
Published: August 2011

AbstractAnimal models simulating osteoarthritis are frequently associated with irreversible changes in biomechanics. Although these models successfully induce osteoarthritis, results of experimental repair procedures are impaired by biomechanical problems. The aim of this study was to define the critical size of a chondral lesion to induce unicompartmental osteoarthritis in a stable joint. Sixteen sheep were randomly divided into four treatment groups. A cartilage defect (7‐ or 14‐mm diameter) was created in the weight‐bearing zone of the medial femoral condyle. The sheep were mobilized for 6 or 12 weeks. Osteoarthritis was determined by gross assessment, India ink staining, histology (Mankin score), and analysis of COMP in the serum. In the 6‐week group, only minor osteoarthritis was registered for either defect size. After 12 weeks, the 14‐mm defect induced minor osteoarthritis at the femoral condyle and caused significant degenerative changes at the tibial articular cartilage and the meniscus. The 7‐mm defect created focal unicompartmental osteoarthritis at the medial femoral condyle and minor degenerative changes at the corresponding tibia. A 7‐mm full‐thickness chondral defect with a weight‐bearing regimen of 12 weeks induced local osteoarthritis at the medial compartment in an otherwise stable joint as aimed. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 30:214–220, 2012
Antimicrobial and Hemolytic Activities of Copolymers with Cationic and Hydrophobic Groups: A Comparison of Block and Random Copolymers
Authors: Wang Yanqiang , Xu Junjuan , Zhang Yueheng , Yan Husheng , Liu Keliang 
Published: August 2011

AbstractRandom and diblock copolymers of 2‐(N,N‐dimethylamino)ethyl methacrylate and butyl methacrylate are prepared by ATRP. As mimics of cationic antimicrobial peptides, the random and diblock copolymers show similar antimicrobial activities. In contrast, the diblock copolymers have much lower hemolytic activities than the random copolymers. The cell selectivity (HC50/MIC, where HC50 is the concentration to lyse 50% of human red blood cells and MIC is the minimum concentration to inhibit bacterial growth) of the diblock copolymers are 150 to 27 500 times higher than that of random copolymers with similar compositions. magnified image