bluuebunny/crossref_metadata_2025_split huggingface dataset:
Innovation in the Farm Office for Smart Sustainability Reporting
Authors: Poppe Krijn J. , Vrolijk Hans C.J. , van Asseldonk Marcel A.P.M. 
Published: May 2024

SummaryFarms face an increasing administrative burden due to the push for a more sustainable agri‐food system. Farms are required to demonstrate compliance with various sustainability schemes, and this trend is expected to intensify with a more performance‐based CAP and new directives and regulations. The need for smart data reporting is emphasised, with a focus on minimising the administrative burden, creating useful systems and indicators for farm management, and ensuring auditability.We advocate smart reporting as a solution and innovation in the farm office. The integration of data from Farm Management Information Systems (FMIS) with sustainability indicators is proposed in order to streamline the reporting process. The importance of using technology, such as e‐invoicing and robotic accounting, is highlighted to monitor and report crucial performance data. The integration of FMIS and Farm Financial Accounting (FFA) is proposed as a solution to enhance auditability and reduce manual input. The potential benefits of fully digital invoices and delivery notes to further streamline data exchange are proposed. Additionally, the paper discusses the role of central databases in the dairy sector.Policy implications for governments in promoting data‐intensive relationships with farmers are identified. They build upon previous policy measures that involved accounting within farms and the digital exchange of data.The paper concludes by emphasising the importance of supporting innovation in the farm office to unlock the full potential of technologies like blockchain, big data analysis, artificial intelligence and sustainability management.
Sensory, emotional, and appropriateness of plant‐ and meat‐based burgers
Authors: Sogari Giovanni , Grasso Simona , Caputo Vincenzina , Gómez Miguel I. , Mora Cristina , Schouteten Joachim J. 
Published: May 2024

AbstractThe plant‐based meat alternative market is experiencing rapid growth. However, whether this growth extends to mainstream consumers will depend on the sensory profile, emotional profile, and situational appropriateness of these products. This study provides a sensory comparison between two plant‐based burgers, one hybrid burger, and a conventional 100% ground beef burger. The sensory evaluation was carried out under blind and informed conditions using a between‐subject design. Participants (n = 177) were asked to rate the appearance, flavor, odor, and texture of each product and indicate their overall liking. In addition, 26 sensory terms were evaluated using the rate‐all‐that‐apply technique. The study also measured the emotional profile and the situational appropriateness elicited by each product using the check‐all‐that‐apply technique. The results showed that (a) in the blind condition, there were no significant differences observed in overall liking across the four burgers; (b) the plant‐based burger made with pea protein received the lowest overall liking score, and its evaluation was not positively influenced by product information disclosure; (c) providing product information influenced the perceived intensity of the attributes associated with meat; (d) discriminatory ability for emotions was higher in the informed condition; and (e) for the situational appropriateness, when prioritizing healthy eating, participants considered plant‐based burgers more suitable than the groundbeef burger.Practical ApplicationOur results demonstrate that product descriptions could have an impact on consumer acceptance of different meat burger alternatives. In order to launch successfull meat alternatives, product developers and communication marketing specialists should consider the extent to which these alternatives resemble regular meat products in terms of their sensory and emotional profiles and context of use.
Letter: Presence of progression or absence of response? Alternative trial designs for immunotherapy of advanced hepatocellular carcinoma. Authors' reply
Authors: Mohr Raphael , Tacke Frank , Roderburg Christoph 
Published: May 2024

LINKED CONTENTThis article is linked to Jost‐Brinkmann et al papers. To view these articles, visit https://doi.org/10.1111/apt.17441 and https://doi.org/10.1111/apt.17985
Pharmacological inhibition of STING reduces neuroinflammation‐mediated damage post‐traumatic brain injury
Authors: Fryer Amelia L. , Abdullah Amar , Mobilio Frank , Jobling Andrew , Moore Zachery , de Veer Michael , Zheng Gang , Wong Bruce X. , Taylor Juliet M. , Crack Peter J. 
Published: May 2024

Background and PurposeTraumatic brain injury (TBI) remains a major public health concern worldwide with unmet effective treatment. Stimulator of interferon genes (STING) and its downstream type‐I interferon (IFN) signalling are now appreciated to be involved in TBI pathogenesis. Compelling evidence have shown that STING and type‐I IFNs are key in mediating the detrimental neuroinflammatory response after TBI. Therefore, pharmacological inhibition of STING presents a viable therapeutic opportunity in combating the detrimental neuroinflammatory response after TBI.Experimental ApproachThis study investigated the neuroprotective effects of the small‐molecule STING inhibitor n‐(4‐iodophenyl)‐5‐nitrofuran‐2‐carboxamide (C‐176) in the controlled cortical impact mouse model of TBI in 10‐ to 12‐week‐old male mice. Thirty minutes post‐controlled cortical impact surgery, a single 750‐nmol dose of C‐176 or saline (vehicle) was administered intravenously. Analysis was conducted 2 h and 24 h post‐TBI.Key ResultsMice administered C‐176 had significantly smaller cortical lesion area when compared to vehicle‐treated mice 24 h post‐TBI. Quantitative temporal gait analysis conducted using DigiGait™ showed C‐176 administration attenuated TBI‐induced impairments in gait symmetry, stride frequency and forelimb stance width. C‐176‐treated mice displayed a significant reduction in striatal gene expression of pro‐inflammatory cytokines Tnf‐α, Il‐1β and Cxcl10 compared to their vehicle‐treated counterparts 2 h post‐TBI.Conclusion and ImplicationsThis study demonstrates the neuroprotective activity of C‐176 in ameliorating acute neuroinflammation and preventing white matter neurodegeneration post‐TBI. This study highlights the therapeutic potential of small‐molecule inhibitors targeting STING for the treatment of trauma‐induced inflammation and neuroprotective potential.
Clinical and radiographic performance of late placed and early loaded dental implants with a conditioned hydrophilic surface in posterior mandible sites: A prospective case series with an 8.5‐ to 9.5‐year follow‐up
Authors: Molinero‐Mourelle Pedro , Schimmel Martin , Forrer Fiona Alena , Hicklin Stefan Paul , Raabe Clemens , Chappuis Vivianne , Fonseca Manrique 
Published: May 2024

AbstractObjectiveTo assess the clinical outcomes by means of implant and prosthetic survival of late placed and early loaded implants with a hydrophilic, moderately rough surface for partially edentulous patients after a follow‐up of 8.5 to 9.5 years.Materials and methodsA prospective case series study involving 15 patients with single, late placed and early loaded implants in the posterior mandible was performed. Clinical and radiographical parameters, including biological and technical complications and patient satisfaction, were assessed.ResultsFrom an initial sample of 15 patients, 12 were included. A total of 16 implants were observed. After a mean follow‐up of 9 years and 7 months (SD ± 3.8 months), implant success and survival rate were 100%. The prosthetic survival rate was 100%, and the prosthetic success rate was 93.8% since a major chipping was observed. No biological complications were observed, and the mean modified plaque index was 0.03 (SD ± 0.09) with a mean probing pocket depth of 2.95 mm (SD ± 0.09). A mean marginal bone level (MBL) of 0.04 mm (SD ± 0.88) and a mean VAS of 9.42 (SD ± 0.90) for patient satisfaction were recorded.ConclusionLate placed and early loaded implants with a moderately rough endosseal surface are a reliable option for rehabilitating partially edentulous patients. An implant survival rate of 100% and a prosthodontic success rate of 93.8% were observed. Patient satisfaction scores were high and peri‐implant hard and soft tissues remained healthy. The study findings should be carefully interpreted because of the small sample.
Comparative real‐world outcomes of dupilumab versus endoscopic sinus surgery in the treatment of severe CRSwNP patients
Authors: De Corso Eugenio , Porru Davide Paolo , Corbò Marco , Montuori Claudio , De Maio Gabriele , Mastrapasqua Rodolfo Francesco , Panfili Marco , Spanu Camilla , Di Bella Giuseppe Alberto , D'Agostino Giuseppe , Rizzuti Alberta , Passali Giulio Cesare , Galli Jacopo 
Published: May 2024

AbstractIntroductionManagement of severe chronic rhinosinusitis with nasal polyps (CRSwNP) has changed significantly in recent years, with different treatments now available including biologics and endoscopic sinus surgery (ESS), although there are still few comparative studies. We aimed to compare 1‐year outcomes of patients with severe CRSwNP treated with dupilumab or ESS plus intranasal corticosteroids (INCS).MethodsIn this retrospective, real‐life, observational, cohort study, we enrolled 101 patients with severe CRSwNP who were treated with INCS and either ESS (n = 49) or dupilumab (n = 52). The following outcomes were considered: nasal polyp score (NPS), Sino Nasal Outcome Test‐22 (SNOT‐22), visual analogue scale (VAS) for specific symptoms, Sniffin' Sticks identification test (SSIT), need for oral corticosteroids (OCS) and local eosinophilia detected by nasal cytology.ResultsΔNPS was significantly higher in the surgery group up to 12 months when the difference with dupilumab group was no longer significant (ΔNPS: 4 vs. 4.1). ΔVAS rhinorrhoea, ΔVAS smell and ΔSNOT‐22 were significantly higher in the dupilumab group at 12 months (p < .05). SSIT scores were significantly better in the dupilumab group starting from the first month of follow‐up (p < .05). In the dupilumab group, only 6.1% of patients had detectable local eosinophilia compared to 57% in the surgery group alongside with a lower need for OCS (16.3% vs. 61%).ConclusionsBoth dupilumab and ESS were effective in improving outcomes in patients with severe CRSwNP over 12 months. Nevertheless, patients treated with dupilumab had greater improvement in terms of SNOT‐22, VAS rhinorrhoea, VAS smell and SSIT scores, with better control of local inflammation and less need for OCS.
Berberine attenuates obesity‐induced insulin resistance by inhibiting miR‐27a secretion
Authors: Du Junda , Zhu Yu , Yang Xuehan , Geng Xinru , Xu Yang , Zhang Meishuang , Zhang Ming 
Published: May 2024

AbstractIntroductionBerberine (BBR) is an alkaloid found in plants. It has neuroprotective, anti‐inflammatory and lipid‐lowering activity. However, the efficacy of treatment with BBR and the mechanisms through which it acts need further study.AimsThis study investigated the therapeutic effects and the mechanism of action of BBR on obesity‐induced insulin resistance in peripheral tissues.MethodsHigh‐fat‐fed C57BL/6J mice and low‐fat‐fed C57BL/6J mice with miR‐27a overexpression were given BBR intervention (100 mg/kg, po), and the oral glucose tolerance test (OGTT) and insulin tolerance test (ITT) were performed. Palmitic acid‐stimulated hypertrophic adipocyte models were treated with BBR (10 μM). Related indicators and protein expression levels were examined.ResultsThe AUCs of the OGTT and the ITT in the BBR intervention group were reduced significantly (p < 0.01) (p < 0.05), and the serum biochemical parameters, including FBG, TC, TG and LDL‐C were significantly reduced after BBR intervention. In the in vitro experiments, the triglyceride level and volume of lipid droplets decreased significantly after BBR intervention (p < 0.01) (p < 0.05). Likewise, BBR ameliorates skeletal muscle and pancreas insulin signalling pathways in vivo and in vitro.DiscussionThe results showed that BBR significantly ameliorated insulin resistance, reduced body weight and percent body fat and improved serum biochemical parameters in mice. Likewise, BBR reduced triglyceride level and lipid droplet volume in hypertrophic adipocytes, BBR improved obesity effectively. Meanwhile, BBR ameliorated the histomorphology of the pancreas, and skeletal muscle and pancreas insulin related signalling pathways of islets in in vitro and in vivo experiments. The results further demonstrated that BBR inhibited miR‐27a levels in serum from obese mice and supernatant of hypertrophic adipocytes. miR‐27a overexpression in low‐fat fed mice indicated that miR‐27a caused insulin resistance, and BBR intervention significantly improved the miR‐27a induced insulin resistance status.ConclusionThis study demonstrates the important role of BBR in obesity‐induced peripheral insulin resistance and suggest that the mechanism of its effect may be inhibition of miR‐27a secretion.
Gender disproportionality in special education: An analysis of odd ratios and trends
Authors: Akgul Savas , Yakut Ayse Dilsad 
Published: May 2024

AbstractIn Turkey, the special education population has steadily increased since 2006. By generating a 16‐year period of data obtained from the National Education Statistics (NES) published annually by the Presidency of Strategy Development of the Ministry of National Education, we synthesize the gender odds ratios and trends by special education categories and/or educational settings. We used odds ratios and the Mann‐Kendall test for data analysis. Gender disproportionality exists in favour of males with special needs in the majority of educational settings. In addition, we found uptrends, downtrends, and no trends for gender odds ratios. Gender disproportionality is discussed, along with implications for research and practice.
What alleviates the harmful effect of strain on recovery from work of 4478 health and social services workers? A cross‐sectional study
Authors: Selander Kirsikka , Korkiakangas Eveliina , Laitinen Jaana 
Published: May 2024

AbstractAimTo analyse whether the harmful effect of job demands on recovery can be alleviated by healthy lifestyle, psychological recovery experiences and job resources. We also describe their prevalence among employees in different types of eldercare service and in the health and social services sector in general.DesignCross‐sectional study.MethodsThe data were collected using a self‐report survey in 2020 in the health and social services sector organizations (n = 4478). Employees were classified as the following service types: general health and social services (N = 3225), home care (N = 452), service housing (N = 550) and outpatient and ward care (N = 202). The data were analysed using percentages, cross‐tabulations and logistic regression analysis.ResultsPoor recovery, high job demands, low appreciation and low autonomy in terms of worktime and breaks were more prevalent in eldercare. Employers could alleviate the risk of high job demands by offering job resources—appreciation, autonomy in terms of worktimes and breaks—and motivating employees to maintain healthy lifestyle habits and use recovery experiences such as relaxation.ConclusionThe study emphasizes the importance of appreciation in the health and social services sector context. Even with moderate levels of appreciation employers can protect employees from poor recovery from work in the demanding health and social services work environment.ImpactEldercare employees face continuous and accumulating work strain at the same time as the sector struggles against a labour shortage. One way to prevent the harmful consequences of strain is to enhance recovery from work.Employers could alleviate the risk of high job demands and poor recovery by showing appreciation and giving employees more autonomy in terms of work time and breaks during the workday. This could also motivate employees to keep up healthy lifestyle habits and use their recovery experiences. Results are important especially in the daily management of HSS work.What Does this Paper Contribute to the wider Global Clinical Community?Managers in the health and social services sector and eldercare can use these findings to promote recovery from work.Reporting MethodSTROBE checklist.Patient or Public ContributionNo patient or public contribution.
Associations between trauma exposure and irritability within the family unit: a network approach
Authors: Cotter Grace , Morreale Kristina , Valdegas Amanda , Fish Meghan , Beebe Rebecca , Grasso Damion , Stover Carla , Tseng Wan‐Ling 
Published: May 2024

BackgroundPediatric irritability is a pervasive psychiatric symptom, yet its etiology remains elusive. While trauma exposure may contribute to the development of irritability, empirical research is limited. This study examined the prevalence of irritability among trauma‐exposed children, identified factors that differentiate trauma‐exposed children with and without irritability, and employed a network analysis to uncover associations between irritability and trauma exposure in the family unit.MethodsSample included 676 children (56.3% male, mean age = 9.67 ± 3.7 years) and their parents referred by the Connecticut Department of Children and Families to Fathers for Change – a psychotherapy intervention designed to reduce intimate partner violence (IPV) and child maltreatment. Child's trauma exposure, post‐traumatic stress disorder (PTSD) symptoms, and irritability were assessed pre‐intervention using self‐ and caregiver‐report. Parents self‐reported their childhood and adulthood trauma exposures, PTSD symptoms, irritability, psychopathology, and IPV.ResultsAcross caregiver‐ and child‐reports, 16%–17% of children exhibited irritability. Irritable children experienced greater trauma exposure, interpersonal violence, emotional abuse, and PTSD severity. They had caregivers, particularly mothers, with greater trauma histories, IPV, and psychopathology. Network analysis revealed 10 nodes directly correlated to child's irritability including child's PTSD severity, parental IPV (specifically psychological violence), and parental psychopathology.ConclusionsResults provide initial empirical evidence that pediatric irritability is linked to trauma exposure, suggesting trauma histories be considered in the diagnosis and treatment of irritability. Interventions addressing caregiver trauma, IPV, and psychopathology may ameliorate pediatric irritability. Future studies could benefit from adopting network approaches with longitudinal or time series data to elucidate causality and points of intervention.
PIONEER REAL Japan: Baseline characteristics of a multicenter, prospective, real‐world study of oral semaglutide in adults with type 2 diabetes in clinical practice in Japan
Authors: Suzuki Ryo , Amadid Hanan , Major‐Pedersen Atheline , Yabe Daisuke 
Published: May 2024

ABSTRACTAims/IntroductionPIONEER REAL Japan was a non‐interventional, multicenter, prospective study investigating oral semaglutide in adults with type 2 diabetes in routine clinical practice. We report baseline characteristics of participants enrolled in this study.Materials and MethodsAdults aged ≥20 years with type 2 diabetes but no previous treatment with injectable glucose‐lowering medication were enrolled. Participants initiated oral semaglutide at their treating physician's discretion and were followed for 34–44 weeks. Participants were stratified into <75‐year‐old and ≥75‐year‐old subgroups.ResultsA total of 624 participants initiated the study. The mean (standard deviation) age was 64.1 years (14.1), the mean (standard deviation) body weight was 72.4 kg (16.1), and the mean (standard deviation) body mass index was 27.5 kg/m2 (5.0). Participants had a median (interquartile range) type 2 diabetes duration of 9.3 years (4.2, 15.2) and mean (standard deviation) glycated hemoglobin 7.7% (1.1). Most (75.6%) participants were taking glucose‐lowering medications at baseline; the most common was metformin (51.9%). The main reasons for initiating oral semaglutide were glycemic control and weight loss. Most (86.0%) participants had an individualized target for glycemic control of glycated hemoglobin ≤7%. The <75‐year‐old subgroup was heavier (mean [standard deviation] body mass index 28.6 kg/m2 [5.2] vs 25.1 kg/m2 [3.4]) but had comparable glycated hemoglobin levels (mean [standard deviation] 7.7% [1.2] vs 7.8% [1.0]) to the ≥75‐year‐old subgroup.ConclusionsPIONEER REAL Japan describes the characteristics of individuals with type 2 diabetes prescribed oral semaglutide. The baseline characteristics provide insights into Japanese individuals with type 2 diabetes prescribed oral semaglutide in clinical practice.
An integrative approach highlights the discrepancy in the genetic, phenotypic, and presumptive taxonomic structure of Phoxinus (Actinopterygii, Leuciscidae, Phoxininae) in Bulgaria
Authors: Palandačić Anja , Diripasko Oleg A. , Kirchner Sandra , Stefanov Tihomir , Bogutskaya Nina G. 
Published: May 2024

AbstractThe present drainage network of Bulgaria is the result of a complex Neogene and Quaternary evolution. Karst, which has developed on 23% of the territory, further complicates the hydrological pattern. Fresh waters of Bulgaria drain into the Black Sea and the Aegean Sea basins and can be roughly divided into the Danube (Middle and Lower Danube), non‐Danube Black Sea, East Aegean, and West Aegean hydrological regions. Phoxinus, a small leuciscid fish, has a mosaic distribution in all four of these regions, inhabiting small mountainous and semi‐mountainous streams. Based on morphology, it was identified as three species, Phoxinus phoxinus in the Danube, Phoxinus strandjae in the non‐Danube, and Phoxinus strymonicus in West Aegean region. Later, molecular data revealed Phoxinus csikii and Phoxinus lumaireul in the Middle Danube and P. csikii in the Lower Danube. Phoxinus has been the focus of many studies, showing a high molecular and morphological diversity, which is not entirely consistent with previous morphology‐only‐based taxonomic concepts. In this study, molecular (a mitochondrial marker and a nuclear marker) and morphological data from both historical and recently sampled collections were analysed to assess the applicability of the integrative approach in Phoxinus. The results showed a significant influence of the complex paleo‐ and recent hydrology on the currently observed genetic structure of the considered populations and species. Furthermore, the study also demonstrated a strong influence of phenotypic plasticity on the morphological analysis of Phoxinus and the lack of a clear differentiation between P. csikii and P. strandjae. A barcoded specimen was designated as neotype to fix the species named P. strandjae in the current taxonomic concept. Finally, a significant discordance between genetically delimited clades and phenotypic groups did not allow a proper delineation of the species distributed in Bulgaria, demonstrating that more molecular markers are needed for further taxonomic study of the Phoxinus complex.