bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a multimodal geomarker pipeline to assess the impact of social, economic, and environmental factors on pediatric health outcomes
Authors: Manning Erika Rasnick , Duan Qing , Taylor Stuart , Ray Sarah , Corley Alexandra M S , Michael Joseph , Gillette Ryan , Unaka Ndidi , Hartley David , Beck Andrew F , Brokamp Cole ,   RISEUP Research Team, Anyigbo Chidiogo , Crosby Lori , de Leon Magdely Diaz , Egbo John , Foley Ben , Henize Adrienne , Jones Margaret , Jones Nana-Hawa Yayah , Kahn Robert , Krantz Landon , Lipps Lauren , Power-Hayes Alexandra , Quinn Charles , Quinonez Elizabeth , Riley Carley , Sandoval Laura , Shook Lisa , Steller Jeffrey 
Published: May 2024

Abstract

Objectives
We sought to create a computational pipeline for attaching geomarkers, contextual or geographic measures that influence or predict health, to electronic health records at scale, including developing a tool for matching addresses to parcels to assess the impact of housing characteristics on pediatric health.

Materials and Methods
We created a geomarker pipeline to link residential addresses from hospital admissions at Cincinnati Children’s Hospital Medical Center (CCHMC) between July 2016 and June 2022 to place-based data. Linkage methods included by date of admission, geocoding to census tract, street range geocoding, and probabilistic address matching. We assessed 4 methods for probabilistic address matching.

Results
We characterized 124 244 hospitalizations experienced by 69 842 children admitted to CCHMC. Of the 55 684 hospitalizations with residential addresses in Hamilton County, Ohio, all were matched to 7 temporal geomarkers, 97% were matched to 79 census tract-level geomarkers and 13 point-level geomarkers, and 75% were matched to 16 parcel-level geomarkers. Parcel-level geomarkers were linked using our exact address matching tool developed using the best-performing linkage method.

Discussion
Our multimodal geomarker pipeline provides a reproducible framework for attaching place-based data to health data while maintaining data privacy. This framework can be applied to other populations and in other regions. We also created a tool for address matching that democratizes parcel-level data to advance precision population health efforts.

Conclusion
We created an open framework for multimodal geomarker assessment by harmonizing and linking a set of over 100 geomarkers to hospitalization data, enabling assessment of links between geomarkers and hospital admissions.
Systematic Review and Meta-analysis of Biodegradable Temporizing Matrix Application for Complex Wound Reconstruction
Authors: Grande Payton Kathryn , Hill David , McElfresh Jenessa , Velamuri Ram , Liu Xiangxia 
Published: May 2024

Abstract
Biodegradable Temporizing Matrix (BTM) is a synthetic dermal template recently developed to reconstruct complex wounds. Current literature describes BTM outcomes in the presence of infection and other comorbidities but is limited by small sample sizes. The purpose of this systemic review and meta-analysis was to determine the current breadth and success of BTM use for complex wound closure. Databases were searched to identify previously published studies describing BTM use in human wounds. Studies were excluded if conducted in vitro, using nonhuman animals, or for procedures irrelevant to wound care. A total of 24 studies met the inclusion criteria, representing 202 patients. The most common injury treated with BTM was burns (68 cases, 33.7%) followed by acute surgical wounds (59 cases, 29.2%). The large majority of patients did not experience any postoperative infections (76.6%). Infected wounds were associated with a 7.5-day delay from BTM to grafting. Univariate regression analyses showed a negative association between time to BTM implantation and age, exposed muscle, and exposed tendon (p &lt; 0.001). In total 92% of patients received BTM implantation less than 2 weeks from admission. A total of 84% of patients had a greater than 95% BTM take. The median time to split-thickness skin graft (STSG) was 34 days, and 92% of patients experienced a greater than 95% STSG survival. To our knowledge, this is the first reported systemic review on the application of BTM for wound reconstruction. According to the published data, BTM is a versatile dermal template for complex wounds coverage with a low risk of infection, high template take rate, and excellent autograft survival.
Towards a relevant African philosophy of education
Authors: Chapfika Blessing 
Published: May 2024

Abstract
Most African philosophers would accept the observation that the ‘African philosophy question’—Is there an African philosophy, and if there is, what is it?—and the different responses to it have not only generated much debate in African philosophy but have also had a significant impact on its development. Since its inception about half a century ago, African philosophy has gained recognition as a member of the world philosophies and established itself as an academic discipline. African philosophy owes these significant inroads, at least in part, to the challenge presented by the African philosophy question and the African predicament. In view of this, it remains crucial that African philosophers continue to clarify the nature of African philosophy as a field of study. Oruka captures the different scholarly responses to the African philosophy question in his famous four varieties or trends of African philosophy: (1) ethnophilosophy, (2) nationalist–ideological philosophy, (3) philosophical sagacity, and (4) professional philosophy. This article offers a general critique of these varieties of African philosophy, reflects on the nature of African philosophy and philosophizing, and argues for a relevant African philosophy of education. The article argues an African philosophy of education that considers features of the African thought that enable and enthuse African people to problem-solve and participate fully in and contribute to world affairs. As such, the article advocates Africanization, criticality, dialogue, and African humanism as the sine qua non features of African philosophy of education. The article also responds to some notable objections to the proposed African philosophy of education.
Interaction of extreme drought and insect herbivores on grassland community is affected by drought pattern
Authors: Luo Ye , Ke Yuguang , Wang Hongqiang , Xu Chong , Gu Qian , Yu Qiang , Smith Melinda D , Madrimov Rajabboy , Samatov Nuriddin , Yang Wei , Wu Honghui 
Published: May 2024

Abstract
Extreme drought and insect herbivores can affect plant community non-independently, and their interaction may be influenced by drought pattern. However, few studies have explored the interaction on plant community structure, and no study has investigated whether the interaction is affected by drought pattern. We explored the interaction of different extreme drought patterns and insect herbivores with a manipulated experiment in a semiarid grassland. There were three treatments for drought: control—ambient precipitation; chronic drought—66% precipitation reduction in the growing season (May–August); intense drought—completely exclusion of rain events from June to July. Herbivores removal and present treatments were imposed within each drought treatment. We found that although herbivores had no significant effects on the impacts of droughts on total species richness, it alleviated the impacts of chronic drought on total cover, and the alleviating role decreased under intense drought. Comparing with intense drought, more increasing of grass cover led to more alleviation under chronic drought associated with the decrease of forb which has low leaf carbon and dry matter content, along with high starch, calcium, magnesium and manganese concentration. These results indicate that the interaction of drought and herbivores is affected by drought pattern, and the changes in leaf traits that reduce herbivores feeding in grass might alleviate the impact of drought on grassland.
On the origin of the quasi-periodic micro-pulses observed in the radio-frequency emission of some neutron stars
Authors: Jones P B 
Published: May 2024

ABSTRACT
The linear relationship between pulsar micro-pulse widths and rotation period is consistent with the existence of a physical length L on the neutron-star surface and seen on the observer arc of transit across the polar cap. Within the ion–proton model it is the width of the minimum area of surface that can support the critical growth rate of the unstable two-beam Langmuir mode that is the source of the radio emission.
NF-κB factors cooperate with Su(Hw)/E4F1 to balance Drosophila/human immune responses via modulating dynamic expression of miR-210
Authors: Zhou Hongjian , Huang Yu , Jia Chaolong , Pang Yujia , Liu Li , Xu Yina , Jin Ping , Qian Jinjun , Ma Fei 
Published: May 2024

Abstract
MicroRNAs (miRNAs) play crucial regulatory roles in controlling immune responses, but their dynamic expression mechanisms are poorly understood. Here, we firstly confirm that the conserved miRNA miR-210 negatively regulates innate immune responses of Drosophila and human via targeting Toll and TLR6, respectively. Secondly, our findings demonstrate that the expression of miR-210 is dynamically regulated by NF-κB factor Dorsal in immune response of Drosophila Toll pathway. Thirdly, we find that Dorsal-mediated transcriptional inhibition of miR-210 is dependent on the transcriptional repressor Su(Hw). Mechanistically, Dorsal interacts with Su(Hw) to modulate cooperatively the dynamic expression of miR-210 in a time- and dose-dependent manner, thereby controlling the strength of Drosophila Toll immune response and maintaining immune homeostasis. Fourthly, we reveal a similar mechanism in human cells, where NF-κB/RelA cooperates with E4F1 to regulate the dynamic expression of hsa-miR-210 in the TLR immune response. Overall, our study reveals a conservative regulatory mechanism that maintains animal innate immune homeostasis and provides new insights into the dynamic regulation of miRNA expression in immune response.
Duckling survival increased with availability of flooded wetland habitat and decreased with salinity concentrations in a brackish marsh
Authors: Peterson Sarah H , Ackerman Joshua T , Hartman C Alex , Greenawalt Andrew C , Casazza Michael L , Herzog Mark P 
Published: May 2024

Abstract
Waterfowl population recruitment is sensitive to duckling survival. We quantified predator types and survival rates for Anas platyrhynchos (Mallard) and Mareca strepera (Gadwall) ducklings in one of the largest brackish water marshes in western North America (Suisun Marsh, California) using 556 radio-tagged ducklings from 284 broods tracked during the 2016 to 2019 breeding seasons. Overall, 78% of ducklings died and 84% of mortalities occurred &lt; 7 days after hatch. After hatching in upland fields, survival was greater for broods that hatched closer to flooded wetlands; broods had a ≥ 75% chance of surviving the move from the nest to water when nests were located ≤ 140 m from the nearest wetland and ≤ 50% chance of surviving when nests were located ≥ 970 m from the nearest wetland. Predation accounted for 91% of mortalities and was attributed to mammals (27.6%), birds (22.0%), snakes (4.4%), and unknown predators (46.0%). Anas platyrhynchos survival to fledging (54 days) was only 3.2% and 0.9% during 2 drier years and 11.7% and 16.7% during 2 wetter years. Mareca strepera survival to fledging was 9.4% to 11.2% among years. Daily survival rates for ducklings generally increased with the amount of flooded wetlands within 0.5 km (A. platyrhynchos) and 1.0 km (M. strepera) of the nest at hatch. Additionally, survival rates increased with duckling age and body mass at hatch for both species and decreased with hatch date for A. platyrhynchos but not M. strepera, which may be partially due to the earlier onset of A. platyrhynchos nesting. For ducklings that survived the initial move to water, survival rates were negatively correlated with salinity and this effect was more pronounced for younger ducklings. Anas platyrhynchos survival to 7 days post hatch decreased by 9.1% (wetter year) to 31.4% (drier year) when ducklings were in 12 ppt water (99th quantile of cumulative salinity concentrations experienced by ducklings) versus 0.5 ppt water. Mareca strepera survival to 7 days decreased by 7.4% when ducklings were in 12 ppt vs. 0.5 ppt water. Our results suggest that maintaining a network of low salinity wetlands within 1 km of upland nesting sites would likely improve duckling survival rates, especially during the critical 7-day period after hatch.
Avian hatching failure rates did not increase during the last century, although species of high conservation concern appear particularly susceptible to factors leading to reproductive failure
Authors: Heggøy Oddvar , Gohli Jostein , Lislevand Terje 
Published: May 2024

Abstract
Increasing levels of global environmental change may have negative impacts on fertility and embryo viability in animals that could explain a recently reported increase in hatching failure in bird eggs across the globe. Here we test this relationship again by analyzing a dataset containing almost twice as many species and covering a longer time period than earlier works (n = 431 species during the period 1906–2022). We also tested for effects of Red List status and global population size. We found that hatching failure rates in a combined group of bird species currently classified as threatened (IUCN Red List categories Critically Endangered, Endangered and Vulnerable) or Near Threatened, peaked in the late 1970s to early 1980s and thereafter declined. A similar trend also existed in species with relatively small global populations. In contrast, no temporal trends were found in species in the Least Concern category, or in species with large global populations. Moreover, hatching failure rates declined significantly with increasing global population sizes. The temporal peak of hatching failure rates in threatened and Near Threatened species corresponds with the peak in environmental levels of the insecticide DDT. While this could suggest that environmental pollution caused the temporal trends in hatching failure rates, effects of inbreeding in small and threatened populations sampled more frequently during this period could not be excluded. Although we found no evidence suggesting that the rates of hatching failure in bird eggs are increasing, the current study supports previous works showing that species of high conservation concern appear to be more susceptible to factors leading to reproductive failure than other species.
Transcription factor ZmEREB97 regulates nitrate uptake in maize (Zea mays) roots
Authors: Wu Qi , Xu Jinyan , Zhao Yingdi , Wang Yuancong , Zhou Ling , Ning Lihua , Shabala Sergey , Zhao Han 
Published: May 2024

Abstract
Maize (Zea mays L.) has very strong requirements for nitrogen. However, the molecular mechanisms underlying the regulations of nitrogen uptake and translocation in this species are not fully understood. Here, we report that an APETALA2/ETHYLENE RESPONSE FACTOR (AP2/ERF) transcription factor ZmEREB97 functions as an important regulator in the N signaling network in maize. Predominantly expressed and accumulated in main root and lateral root primordia, ZmEREB97 rapidly responded to nitrate treatment. By overlapping the analyses of differentially expressed genes and conducting a DAP-seq assay, we identified 1,446 potential target genes of ZmEREB97. Among these, 764 genes were coregulated in 2 lines of zmereb97 mutants. Loss of function of ZmEREB97 substantially weakened plant growth under both hydroponic and soil conditions. Physiological characterization of zmereb97 mutant plants demonstrated that reduced biomass and grain yield were both associated with reduced nitrate influx, decreased nitrate content, and less N accumulation. We further demonstrated that ZmEREB97 directly targets and regulates the expression of 6 ZmNRT genes by binding to the GCC-box-related sequences in gene promoters. Collectively, these data suggest that ZmEREB97 is a major positive regulator of the nitrate response and that it plays an important role in optimizing nitrate uptake, offering a target for improvement of nitrogen use efficiency in crops.
Heat and law enforcement
Authors: Behrer A Patrick , Bolotnyy Valentin 
Published: May 2024

Abstract
Using administrative criminal records from Texas, we show how high temperatures affect the decision-making of police officers, prosecutors, and judges. We find that police reduce the number of arrests made per reported crime on the hottest days and that arrests made on these days are more likely to be dismissed in court. For prosecutors, high temperature on the day they announce criminal charges does not appear to affect the nature and severity of the charges. Judges, however, dismiss fewer cases, issue longer prison sentences, and levy higher fines when ruling on hot days. Our results suggest that the psychological and cognitive consequences of exposure to high temperatures have meaningful consequences for criminal defendants as they interact with the criminal justice system.
Impact of the gut microbiome composition on social decision-making
Authors: Falkenstein Marie , Simon Marie-Christine , Mantri Aakash , Weber Bernd , Koban Leonie , Plassmann Hilke 
Published: May 2024

Abstract
There is increasing evidence for the role of the gut microbiome in the regulation of socio-affective behavior in animals and clinical conditions. However, whether and how the composition of the gut microbiome may influence social decision-making in health remains unknown. Here, we tested the causal effects of a 7-week synbiotic (vs. placebo) dietary intervention on altruistic social punishment behavior in an ultimatum game. Results showed that the intervention increased participants’ willingness to forgo a monetary payoff when treated unfairly. This change in social decision-making was related to changes in fasting-state serum levels of the dopamine-precursor tyrosine proposing a potential mechanistic link along the gut–microbiota–brain-behavior axis. These results improve our understanding of the bidirectional role body–brain interactions play in social decision-making and why humans at times act “irrationally” according to standard economic theory.
The Targeted Motor Control Screening Tool Is Valid for 4-Year-Old Children
Authors: Brown Laura , Bacon Amanda , Pacey Verity , Ilhan Emre 
Published: May 2024

Abstract

Objective
The objective was to determine the validity of the Targeted Motor Control (TMC) screening tool with the Neurosensory Motor Developmental Assessment (NSMDA) in 4-year-old children.

Methods
In this single cohort observational study, children (3 years 9 months to 4 years 5 months) completed the TMC and the NSMDA in a randomized order 5 to 14 days apart.

Results
Seventy-six children (mean age = 4 years 2 months; standard deviation = 2.5 months; n = 35 male) completed both assessments. Forty-two children performed within the normal range on the NSMDA. There were significant and positive moderate correlations between the item totals overall and for each area on the NSMDA and the TMC (r = 0.40–0.61), and between the NSMDA functional grade for each area and the corresponding TMC areas (r = 0.47–0.67). However, the correlation between the NSMDA sensorimotor functional grade and the TMC sensory score was significant but low and positive (r = 0.35). The optimal cut-off score for detecting children at risk of atypical development on the TMC was a score of &lt;9 (n = 42) (sensitivity = 82.4%; specificity = 66.7%), with a positive likelihood ratio of 2.47 (95% confidence interval [CI] = 1.57–3.89) and a negative likelihood ratio of 0.26 (95% CI = 0.12–0.56).

Conclusion
The TMC is a valid screening tool to identify 4-year-old children at risk of motor delay.

Impact
Early identification of developmental concerns using a validated screening tool is recommended. The TMC is a valid performance-based screening tool that can be used to identify children at risk of atypical motor development who would benefit from further developmental assessment so that, if indicated, timely intervention can be implemented.
Erosive progression by high-resolution peripheral quantitative computed tomography and conventional radiography in rheumatoid arthritis
Authors: Therkildsen Josephine , Klose-Jensen Rasmus , Hänel Mathias , Langdahl Bente L , Thygesen Jesper , Thomsen Jesper S , Manske Sarah L , Keller Kresten K , Hauge Ellen-Margrethe 
Published: May 2024

Abstract

Objectives
To investigate the diagnostic accuracy of high-resolution peripheral quantitative computed tomography (HR-pQCT) to assess erosive progression during 1 year compared with conventional radiography (CR) in rheumatoid arthritis (RA).

Methods
This prospective study included 359 patients with RA (disease duration ≥5 years) between March 2018 and October 2020. HR-pQCT and CR were obtained at inclusion and after 1 year. Erosive assessment was performed at two metacarpophalangeal joints of the dominant hand using HR-pQCT, and progression was defined as an increase in erosion number ≥1 or an increase in erosive volume &gt; least significant change. CR of hands, wrists and feet was evaluated using Sharp/van der Heijde scores and erosive progression was defined as a 1.1-point increase in erosion score according to the smallest detectable change.

Results
In paired analyses (n = 310), erosive progression was identified in 30 patients using CR and in 40 patients using HR-pQCT. In the 40 patients with erosive progression on HR-pQCT, progression was not identified by CR in 33 patients. Adding HR-pQCT to CR doubled the proportion of patients identified with progression from 30 (10%) to 63 (20%) patients. Using CR as the reference, the sensitivity of HR-pQCT for identifying erosive progression was 23.3% (95% CI: 9.9, 42.3%) and the specificity was 88.2% (95% CI: 83.8, 91.7%).

Conclusion
A substantial proportion of patients with erosive progression are overlooked using CR only to monitor erosive progression. Adding high-resolution peripheral CT to CR doubles the proportion of patients who may benefit from individualized therapy targeting erosive progression in RA.