bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distribution pattern of the adenomatoid odontogenic tumor: a retrospective study from the files of a government teaching hospital, Tamil Nadu, Chennai, India
Authors: Arunaa Sivasubramanian , Ponniah Irulandy 
Published: July 2010

AbstractAim:  To determine the distribution and clinicopathologic characteristics of adenomatoid odontogenic tumors from Tamil Nadu, India, to provide meaningful data for comparison among different population groups, mainly in the Asian context.Methods:  Forty‐three adenomatoid odontogenic tumors were reviewed from 493 odontogenic tumors recorded between 1970 and 2008. The data pertaining to age, sex, anatomic site, associated impacted teeth and radiographic details, provisional diagnoses, and macroscopic and microscopic details of the 43 odontogenic tumors were reviewed.Results:  The relative frequency of adenomatoid tumors comprised 8.72% of the total odontogenic tumors. The age range was 9–30 years, with a mean age of 16.88 years for combined adenomatoid odontogenic tumors. The mean age for other variants of adenomatoid odontogenic tumors assessed in this study differed slightly between sexes. Forty occurred within the bone and three peripherally. In general, the maxilla was the predominant site of involvement (72.5%), and the anterior region of jaw was affected in 92.5%. For combined adenomatoid odontogenic tumors, the male‐to‐female ratio was 1:1.26, and the maxilla‐to‐mandible ratio was 2.9:1. Microscopically, cystic lesions comprised 37.5% and occurred more often in males with a lower mean age.Conclusion:  The present study shows variations in the distribution of adenomatoid odontogenic tumors within the population assessed, but no definite conclusion emerged with regard to regional or ethnic effect.
Vulnerability of white spruce tree growth in interior Alaska in response to climate variability: dendrochronological, demographic, and experimental perspectivesThis article is one of a selection of papers from The Dynamics of Change in Alaska’s Boreal Forests: Resilience and Vulnerability in Response to Climate Warming.
Authors: McGuire A. David , Ruess Roger W. , Lloyd A. , Yarie J. , Clein Joy S. , Juday Glenn P. 
Published: July 2010

This paper integrates dendrochronological, demographic, and experimental perspectives to improve understanding of the response of white spruce ( Picea glauca (Moench) Voss) tree growth to climatic variability in interior Alaska. The dendrochronological analyses indicate that climate warming has led to widespread declines in white spruce growth throughout interior Alaska that have become more prevalent during the 20th century. Similarly, demographic studies show that white spruce tree growth is substantially limited by soil moisture availability in both mid- and late-successional stands. Interannual variability in tree growth among stands within a landscape exhibits greater synchrony than does growth of trees that occupy different landscapes, which agrees with dendrochronological findings that the responses depend on landscape position and prevailing climate. In contrast, the results from 18 years of a summer moisture limitation experiment showed that growth in midsuccessional upland stands was unaffected by moisture limitation and that moisture limitation decreased white spruce growth in floodplain stands where it was expected that growth would be less vulnerable because of tree access to river water. Taken together, the evidence from the different perspectives analyzed in this study clearly indicates that white spruce tree growth in interior Alaska is vulnerable to the effects of warming on plant water balance.
Demography of snowshoe hares in relation to regional climate variability during a 10-year population cycle in interior AlaskaThis article is one of a selection of papers from The Dynamics of Change in Alaska’s Boreal Forests: Resilience and Vulnerability in Response to Climate Warming.
Authors: Kielland K. , Olson K. , Euskirchen E. 
Published: July 2010

We monitored populations of snowshoe hares ( Lepus americanus , Erxleben) in interior Alaska for 10 years from 1999 to 2008. During this period, fall densities of hares fluctuated approximately 14-fold. High population growth rates over summer (λ = 1.83–8.00) were followed by large population declines over winter (λ = 0.16–0.82). Young-of-the-year hares tended to gain mass over winter, while adult hares tended to loose body mass. The average mass of adult hares was significantly lower during the low phase of the cycle compared with when hares were abundant. Overwinter survival of juveniles relative to adults decreased strongly as a function of the frequency of snowfall events. However, effects of temperature and precipitation on hare demography were season dependent and appear to act as modifiers of the primary controls over population dynamics (predation and food) rather than as direct sources of mortality. The rapid changes in green-up and snow-up in interior Alaska may affect forage conditions as well as the timing of molt in snowshoe hares. The strength of these interactions may increase in importance if the asynchrony of environmental seasonality and life history traits of snowshoe hares becomes more pronounced as the climate continues to change.
Long-term effects of fire and fire-return interval on population structure and growth of longleaf pine (Pinus palustris)
Authors: Ford Chelcy R. , Minor Emily S. , Fox Gordon A. 
Published: July 2010

We investigated the effect of fire and fire frequency on stand structure and longleaf pine ( Pinus palustris P. Mill.) growth and population demography in an experimental research area in a southwest Florida sandhill community. Data were collected from replicated plots that had prescribed fire-return intervals of 1, 2, 5, or 7 years or were left unburned. Experimental treatment burns have been ongoing since 1976. Plots were sampled to estimate species distribution, stand structure, and longleaf pine density in four developmental stage classes: grass, bolting, small tree, and large tree. Tree-ring growth measurements in combination with burn history were used to evaluate the effects of fire and fire-return interval on basal area increment growth. Fire-return interval impacted stand structure and longleaf pine population structure. Our results suggest that recruitment from the bolting stage to later stages may become adversely affected with very frequent fires (e.g., every 1 or 2 years). Although adult tree productivity was negatively impacted during fire years, tree growth during years between fire events was resilient such that growth did not differ significantly among fire-return intervals. Our study shows that the longleaf pine population as a whole is strongly regulated by fire and fire-return interval plays a key role in structuring this population.
Mafic alkaline metasomatism in the lithosphere underneath East Serbia: evidence from the study of xenoliths and the host alkali basalts
Authors: Cvetković V. , Downes H. , Höck V. , Prelević D. , Lazarov M. 
Published: July 2010

Abstract

Effects of mafic alkaline metasomatism have been investigated by a combined study of the East Serbian mantle xenoliths and their host alkaline rocks. Fertile xenoliths and tiny mineral assemblages found in depleted xenoliths have been investigated. Fertile lithologies are represented by clinopyroxene (cpx)-rich lherzolite and spinel (sp)-rich olivine websterite containing Ti–Al-rich Cr-augite, Fe-rich olivine, Fe–Al-rich orthopyroxene and Al-rich spinel. Depleted xenoliths, which are the predominant lithology in the suite of East Serbian xenoliths, are harzburgite, cpx-poor lherzolite and rare Mg-rich dunite. They contain small-scale assemblages occurring as pocket-like, symplectitic or irregular, deformation-assisted accumulations of metasomatic phases, generally composed of Ti–Al- and incompatible element-rich Cr-diopside, Cr–Fe–Ti-rich spinel, altered glass, olivine, apatite, ilmenite, carbonate, feldspar, and a high-TiO
2
(
c
. 11 wt%) phlogopite. The fertile xenoliths are too rich in Al, Ca and Fe to simply represent undepleted mantle. By contrast, their composition can be reproduced by the addition of 5–20 wt% of a basanitic melt to refractory mantle. However, textural relationships found in tiny mineral assemblages inside depleted xenoliths imply the following reaction: opx+sp1 (primary mantle Cr-spinel) ±phlogopite+Si-poor alkaline melt=Ti–Al-cpx+sp2 (metasomatic Ti-rich spinel)±ol±other minor phases. Inversion modelling, performed on the least contaminated and most isotopically uniform host basanites (
87
Sr/
86
Sr=
c
. 0.7031;
143
Nd/
144
Nd=
c
. 0.5129), implies a source that was enriched in highly and moderately incompatible elements (
c
. 35–40× chondrite for U–Th–Nb–Ta, 2× chondrite for heavy rare earth elements (HREE), made up of clinopyroxene, carbonate (
c
. 5%), and traces of ilmenite (
c
. 1%) and apatite (
c
. 0.05%). A schematic model involves: first, percolation of CO
2
- and H
2
O-rich fluids and precipitation of metasomatic hydrous minerals; and, second, the subsequent breakdown of these hydrous minerals due to the further uplift of hot asthenospheric mantle. This model links intraplate alkaline magmatism to lithospheric mantle sources enriched by sublithospheric melts at some time in the past.
Mantle metasomatism by melts of HIMU piclogite components: new insights from Fe-lherzolite xenoliths (Calatrava Volcanic District, central Spain)
Authors: Bianchini Gianluca , Beccaluva Luigi , Bonadiman Costanza , Nowell Geoff M. , Pearson D. Graham , Siena Franca , Wilson Marjorie 
Published: July 2010

Abstract

Mantle xenoliths from the Calatrava Volcanic District (CLV), central Spain, are characterized by a wide compositional range that includes lherzolites (prevalent), as well as minor amounts of wehrlite, olivine (ol)-websterite and rare dunites. They generally have a bulk-rock Mg# of less than 89, lower than any primordial mantle estimates. Intra-suite variations in modal proportions are inconsistent with those predicted by melting models irrespective of the starting composition; mineral and bulk-rock variation diagrams show inconsistencies between the CLV compositions (anomalously enriched in Fe–Ti) and those predicted from the partial melting of primordial mantle material. Processes other than pure melt extraction are confirmed by the whole-rock REE (rare earth element) budget, typically characterized by LREE enrichments, with La
N
/Yb
N
(up to 6.7), probably related to pervasive metasomatism. CLV mantle clinopyroxenes (cpx) generally display fractionated REE patterns with upwards-convex shapes, characterized by low HREE (Tm–Lu) concentrations (typically <6× chondrite) and enrichments in middle–light REE (MREE–LREE) (Nd
N
/Yb
N
up to 7, La
N
/Yb
N
up to 5). These ‘enriched’ cpx compositions either result from re-equilibration of primary mantle cpx with an incoming melt, or represent cpx crystallization directly from the metasomatic agent. The latter was plausibly generated at greater depths in the presence of residual garnet (from peridotite or eclogite starting materials). Separated cpx have homogeneous
87
Sr/
86
Sr compositions between 0.7031 and 0.7032;
143
Nd/
144
Nd ranges from 0.51288 to 0.51295 (εNd 4.74–6.07) and
176
Hf/
177
Hf is in the range 0.28302–0.28265 (εHf −3.6 to 9.0). Unlike mantle xenoliths and alpine-type peridotites from other Iberian occurrences, which range in composition from the depleted mantle (DM) to the enriched mantle (EM), the CLV mantle cpx approach the composition of the HIMU mantle end member, the genesis of which is generally interpreted as the result of long-term recycling of oceanic basalts/gabbros (or their eclogitic equivalent) via ancient subduction. A model is proposed for the mantle evolution under central Iberia, where sublithospheric convective instabilities – possibly triggered by the neighbouring subduction along the Betic collisional belt – could have remobilized deep domains from the mantle ‘transition zone’ (410–660 km), which may include relicts of older subducted slabs. Within these remobilized domains, characterized by the coexistence of peridotite and eclogite and referred to as a ‘piclogite’ association, the eclogites melt preferentially generating Fe–Ti rich melts characterized by a HIMU isotopic signature that infiltrates and metasomatizes the shallower lithospheric mantle.
Geochemical and Sr–Nd isotopic characteristics and pressure–temperature estimates of mantle xenoliths from the French Massif Central: evidence for melting and multiple metasomatism by silicate-rich carbonatite and asthenospheric melts
Authors: Yoshikawa M. , Kawamoto T. , Shibata T. , Yamamoto J. 
Published: July 2010

Abstract

Ultramafic xenoliths from Mont Briançon, Ray Pic and Puy Beaunit in the French Massif Central show variable mineral compositions that indicate a residual origin after various degrees of partial melting of a fertile peridotite. Furthermore, trace element and Sr–Nd isotopic variations of clinopyroxenes indicate mixing processes between depleted mantle and enriched components such as asthenospheric melt and silicate carbonatite melt. Pyroxene geothermometer and CO
2
geobarometer estimates are 860–1060 °C at 0.92–1.10 GPa for Mont Briançon, 930–980 °C at 0.89–1.04 GPa for Ray Pic and 840–940 °C at 0.59–0.71 GPa for Puy Beaunit. From south to north, the xenoliths show the following trends: (1) deeper to shallower origin; (2) more depleted mineral compositions, suggesting higher degrees of partial melting; and (3) more enriched isotopes and trace elements, indicating a mixing process with a silicate-rich carbonatite melt characterized by high H
2
O and K
2
O, possibly during Variscan subduction.
High Levels of Nucleolar Expression of Nucleolin Are Associated with Better Prognosis in Patients with Stage II Pancreatic Ductal Adenocarcinoma
Authors: Peng Lan , Liang John , Wang Hua , Song Xianzhou , Rashid Asif , Gomez Henry F. , Corley Lynda J. , Abbruzzese James L. , Fleming Jason B. , Evans Douglas B. , Wang Huamin 
Published: July 2010

Abstract
Purpose: Nucleolin is a major nucleolar protein that has been shown to be overexpressed in rapidly dividing cells and plays an essential role in cell proliferation and survival. However, the expression and significance of nucleolin in pancreatic ductal adenocarcinoma (PDA) have not been studied.
Experimental Design: We used a tissue microarray consisting of 1.0-mm cores of tumor and paired nonneoplastic pancreatic tissue from 69 pancreaticoduodenectomy specimens with stage II PDA. Nucleolin expression was evaluated by immunohistochemistry and scored quantitatively by image analysis. Nucleolin expression was classified as nucleolin-high or nucleolin-low using the median nucleolin labeling index of 3.5% as cutoff. Staining results were correlated with clinicopathologic features and survival.
Results: Both PDAs and PDA cell lines showed nucleolar staining for nucleolin. Nucleolin expression was higher in PDAs and PDA cell lines than in nonneoplastic ductal epithelial cells. Among the 69 stage II PDAs, 34 (49%) were nucleolin-high. The median overall survival was 65.2 ± 16.3 months for patients who had nucleolin-high PDAs compared with 19.5 ± 3.3 months for patients whose tumors were nucleolin-low (P = 0.03, log-rank method). No significant correlation between nucleolin expression and other clinicopathologic parameters was found. In multivariate analysis, nucleolin expression was a prognostic factor for overall survival in patients with stage II PDA independent of patient's age, gender, tumor size, differentiation, and lymph node status.
Conclusions: Nucleolin was overexpressed in PDAs and PDA cell lines. A high level of nucleolar expression of nucleolin was an independent prognostic marker for better survival for patients with stage II PDAs. Clin Cancer Res; 16(14); 3734–42. ©2010 AACR.
Inhibition of Src Impairs the Growth of Met-Addicted Gastric Tumors
Authors: Bertotti Andrea , Bracco Cecilia , Girolami Flavia , Torti Davide , Gastaldi Stefania , Galimi Francesco , Medico Enzo , Elvin Paul , Comoglio Paolo M. , Trusolino Livio 
Published: July 2010

Abstract
Purpose: We examined whether inhibition of Src tyrosine kinase, a downstream effector of the MET oncogene, can hinder the malignant properties of gastric tumors dependent on Met for growth and survival.
Experimental Design: Sensitivity to Src inhibition was determined in vitro by measuring clonogenic survival (anchorage-independent growth) and in vivo by establishing xenograft models. Four “Met-addicted” gastric carcinoma cell lines (GTL16, MKN45, HS746T, and SNU5) and three Met-independent gastric carcinoma cell lines (KATO III, AGS, and NCI-N87) were treated with the Src inhibitor saracatinib (AZD0530). In GTL16 and KATO III, Src neutralization was also achieved by dasatinib and RNA interference. The biochemical and transcriptional consequences of Src inhibition were explored using anti-phosphoprotein antibodies and oligonucleotide microarrays.
Results: Inhibition of Src in Met-addicted gastric carcinoma cell lines (a) decreased the phosphorylation/activation levels of signaling intermediates involved in cell proliferation and protection from apoptosis and down-modulated the expression of several cell cycle regulators; (b) reduced anchorage-independent growth; (c) enhanced impairment of cell viability produced by Met inhibition; and (d) delayed tumorigenesis in xenotransplantation models. Immunohistochemical analysis of tumor xenograft tissues following systemic treatment with saracatinib showed a reduction of tumor cell proliferation index, increased apoptosis, and diminished phospho-focal adhesion kinase and phospho-paxillin staining. Tumor stroma parameters such as angiogenesis or inflammatory infiltration were unaffected. In clonogenic survival assays, gastric carcinoma cells without addiction to Met were less sensitive than Met-addicted cells to Src inhibition.
Conclusions: Src is as a key downstream transducer of Met-driven tumor growth. Targeting Src might provide therapeutic benefit in Met-addicted tumors. Clin Cancer Res; 16(15); 3933–43. ©2010 AACR.
Preclinical Colorectal Cancer Chemopreventive Efficacy and p53-Modulating Activity of 3′,4′,5′-Trimethoxyflavonol, a Quercetin Analogue
Authors: Howells Lynne M. , Britton Robert G. , Mazzoletti Marco , Greaves Peter , Broggini Massimo , Brown Karen , Steward William P. , Gescher Andreas J. , Sale Stewart 
Published: July 2010

Abstract
Some naturally occurring flavonols, exemplified by quercetin, seem to possess experimental cancer chemopreventive efficacy. Modulation of p53 is a mechanism thought to contribute to their activity. The hypothesis was tested that a synthetic flavonol, 3′,4′,5′-trimethoxyflavonol (TMFol), can interfere with tumor development and p53 expression in two models of colorectal carcinogenesis, ApcMin mice and human-derived HCT116 adenocarcinoma–bearing nude mice. Mice received TMFol with their diet (0.2%) from weaning to week 16 in the case of ApcMin or from either day 7 before (“TMFol early”) or day 7 after (“TMFol late”) tumor inoculation in HCT116 mice. The ability of TMFol to affect tumor proliferation or apoptosis, as reflected by staining for Ki-67 or cleaved caspase-3, respectively, was studied in HCT116 tumors. TMFol tumor levels were measured by high-performance liquid chromatography. Consumption of TMFol reduced small intestinal adenoma burden in ApcMin mice by 47%, compared with control mice (P &lt; 0.002). The TMFol early regimen approximately halved HCT116 tumor size (P &lt; 0.05), decreased tumor proliferation, and increased apoptosis, whereas the TMFol late regimen had no significant effect when compared with controls. In tumor tissues from mice, in which TMFol reduced tumor development, p53 expression was increased 3-fold in ApcMin and 1.5-fold in HCT116 tumor–bearing mice (P = 0.02). TMFol increased p53 also in cells derived from these tumors. TMFol was detected in HCT116 tumors, but levels did not correlate with tumor burden. TMFol was not mutagenic in the Ames test. The results suggest that chemical modification of the flavonol structure may generate safe and efficacious cancer chemopreventive agents. Cancer Prev Res; 3(8); 929–39. ©2010 AACR.
Cryptotanshinone Inhibits Cancer Cell Proliferation by Suppressing Mammalian Target of Rapamycin–Mediated Cyclin D1 Expression and Rb Phosphorylation
Authors: Chen Wenxing , Luo Yan , Liu Lei , Zhou Hongyu , Xu Baoshan , Han Xiuzhen , Shen Tao , Liu Zhijun , Lu Yin , Huang Shile 
Published: July 2010

Abstract
Cryptotanshinone (CPT), a natural compound isolated from the plant Salvia miltiorrhiza Bunge, is a potential anticancer agent. However, little is known about its anticancer mechanism. Here, we show that CPT inhibited cancer cell proliferation by arresting cells in G1-G0 phase of the cell cycle. This is associated with the inhibition of cyclin D1 expression and retinoblastoma (Rb) protein phosphorylation. Furthermore, we found that CPT inhibited the signaling pathway of the mammalian target of rapamycin (mTOR), a central regulator of cell proliferation. This is evidenced by the findings that CPT inhibited type I insulin-like growth factor I– or 10% fetal bovine serum–stimulated phosphorylation of mTOR, p70 S6 kinase 1, and eukaryotic initiation factor 4E binding protein 1 in a concentration- and time-dependent manner. Expression of constitutively active mTOR conferred resistance to CPT inhibition of cyclin D1 expression and Rb phosphorylation, as well as cell growth. The results suggest that CPT is a novel antiproliferative agent. Cancer Prev Res; 3(8); 1015–25. ©2010 AACR.
Constitutional Inclusion of Animal Rights in Germany and Switzerland: How Did Animal Protection Become an Issue of National Importance?
Authors: Evans Erin 
Published: July 2010

AbstractProvisions for animal rights have been included in the national constitutions of Switzerland (1992, 2000) and Germany (2002). Protective constitutional inclusion is a major social movement success, and in view of the other movements also seeking increased political visibility and responsiveness, it is worth asking how and why nonhuman animals were allowed into this realm of political importance. This research seeks to explain how animal activists achieved this significant goal in two industrialized democracies. Using an approach drawn from the mainstream canon on social movements, this comparative study attempts to show how cultural factors, institutional selectivity, and the influence of spontaneous events, along with the tactic of “frame-bridging,” determined the success of both movements.