bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radical Polymer‐based Positive Electrodes for Dual‐Ion Batteries: Enhancing Performance with γ‐Butyrolactone‐based Electrolytes
Authors: Rudolf Katharina , Voigt Linus , Muench Simon , Frankenstein Lars , Landsmann Justin , Schubert Ulrich S. , Winter Martin , Placke Tobias , Kasnatscheew Johannes 
Published: May 2024

AbstractDual‐ion batteries (DIBs) represent a promising alternative for lithium ion batteries (LIBs) for various niche applications. DIBs with polymer‐based active materials, here poly(2,2,6,6‐tetramethylpiperidinyl‐N‐oxyl methacrylate) (PTMA), are of particular interest for high power applications, though they require appropriate electrolyte formulations. As the anion mobility plays a crucial role in transport kinetics, Li salts are varied using the well‐dissociating solvent γ‐butyrolactone (GBL). Lithium difluoro(oxalate)borate (LiDFOB) and lithium bis(oxalate)borate (LiBOB) improve cycle life in PTMA||Li metal cells compared to other Li salts and a LiPF6‐ and carbonate‐based reference electrolyte, even at specific currents of 1.0 A g−1 (≈10C), whereas LiDFOB reveals a superior rate performance, i. e., ≈90 % capacity even at 5.0 A g−1 (≈50C). This is attributed to faster charge‐transfer/mass transport, enhanced pseudo‐capacitive contributions during the de‐/insertion of the anions into the PTMA electrode and to lower overpotentials at the Li metal electrode.
OMIP‐103: A 35‐marker imaging mass cytometry panel for the co‐detection of HIV and immune cell populations in human formalin fixed paraffin embedded intestinal tissue
Authors: Hu Kevin , O'Neil Thomas , Canete Nicolas , Baharlou Heeva , Harman Andrew 
Published: May 2024

AbstractWe introduce a 35‐marker imaging mass cytometry (IMC) panel for a detailed examination of immune cell populations and HIV RNA in formalin fixed paraffin embedded (FFPE) human intestinal tissue. The panel has broad cell type coverage and particularly excels in delineating subsets of mononuclear phagocytes and T cells. Markers for key tissue structures are included, enabling identification of epithelium, blood vessels, lymphatics, and musculature. The described method for HIV RNA detection can be generalized to other low abundance RNA targets, whether endogenous or pathogen derived. As such, the panel presented here is useful for high parameter spatial mapping of intestinal immune cells and their interactions with pathogens such as HIV.
Preclinical pharmacokinetic studies of villocarine A, an active Uncaria alkaloid
Authors: Chiang Yi‐Hua , Chear Nelson Jeng‐Yeou , Berthold Erin C. , Kuntz Michelle A. , Kanumuri Siva Rama Raju , Senetra Alexandria S. , Ramanathan Surash , McCurdy Christopher R. , Sharma Abhisheak 
Published: May 2024

AbstractVillocarine A is a bioactive indole alkaloid isolated from the Uncaria genus. It has demonstrated vasorelaxation activity and potential to protect the central nervous system. To identify the pharmacokinetic properties of villocarine A, a series of in vitro and in vivo studies have been performed. Villocarine A was found to be highly permeable (15.6 ± 1.6*10−6 cm/s) across human colorectal adenocarcinoma cell monolayer with high protein binding (>91%) in both rat and human plasma. Hepatic extraction ratio of villocarine A was 0.1 in pooled rat liver and 0.2 in human liver microsomes and was found stable in rat plasma at 37°C. Due to the high permeability and low rate of metabolism properties, villocarine A was initially considered suitable for preclinical development and an ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method for quantification (linearity: 1–150 ng/ml) in rat plasma was developed and validated for in vivo studies. Essential pharmacokinetic parameters included the volume of distribution and clearance of villocarine A, which were found to be 100.3 ± 15.6 L/kg and 8.2 ± 1.1 L/h/kg, respectively, after intravenous administration in rats. Following oral dosing, villocarine A exhibited rapid absorption as the maximum plasma concentration (53.2 ± 10.4 ng/ml) occurred at 0.3 ± 0.1 h, post‐dose. The absolute oral bioavailability of villocarine A was 16.8 ± 0.1%. To our knowledge, this was the first pharmacokinetic study of villocarine A, which demonstrated the essential pharmacokinetic properties of villocarine A: large volume distribution, high clearance, and low oral bioavailability in rats.
Wild herbivores and cattle have differing effects on postfire herbaceous vegetation recovery in an African savanna
Authors: Masudi Sherril P. , Odadi Wilfred O. , Kimuyu Duncan M. , Gachuiri Charles K. , Sensenig Ryan L. , Young Truman P. 
Published: May 2024

AbstractFire and herbivory have profound effects on vegetation in savanna ecosystems, but little is known about how different herbivore groups influence vegetation dynamics after fire. We assessed the separate and combined effects of herbivory by cattle and wild meso‐ and megaherbivores on postfire herbaceous vegetation cover, species richness, and species turnover in a savanna ecosystem in central Kenya. We measured these vegetation attributes for five sampling periods (from 2013 to 2017) in prescribed burns and unburned areas located within a series of replicated long‐term herbivore exclosures that allow six different combinations of cattle and wild meso‐ and megaherbivores (elephants and giraffes). Vegetation cover (grasses, mainly) and species richness were initially reduced by burning but recovered by 15–27 months after fire, suggesting strong resilience to infrequent fire. However, the rates of recovery differed in plots accessible by different wild and domestic herbivore guilds. Wildlife (but not cattle) delayed postfire recovery of grasses, and the absence of wildlife (with or without cattle) delayed recovery of forbs. Herbivory by only cattle increased grass species richness in burned relative to unburned areas. Herbivory by cattle (with or without wildlife), however, reduced forb species richness in burned relative to unburned areas. Herbivory by wild ungulates (but not cattle) increased herbaceous species turnover in burned relative to unburned areas. Megaherbivores had negligible modifying effects on these results. This study demonstrates that savanna ecosystems are remarkably resilient to infrequent fires, but postfire grazing by cattle and wild mesoherbivores exerts different effects on recovery trajectories of herbaceous vegetation.
When aposematism is not enough: ExoticRattus rattusshows no mercy for carcasses ofSalamandra salamandrain insular populations
Authors: Velo‐Antón Guillermo 
Published: May 2024

AbstractPredator–prey interaction is a major force driving natural selection. Yet, the identification of species preying on, or consuming, aposematic species is largely unknown. Here, I conduct a study evaluating the role of the exoticRattus rattusas a consumer and possible predator of the aposematic and toxicSalamandra salamandra. I used camera traps to investigate the response ofR. rattustowardsS. salamandracarcasses in two insular populations, Ons and San Martiño (NW Spain), which show remarkable contrasting behaviour (nocturnal vs. diurnal activity) and demographic and phenotypic differences. This study unveilsR. rattusconsumesS. salamandradespite its aposematic colour pattern and toxicity. The high number of salamander carcasses consumed or taken by rats throughout each island (90%–100%) and the lack of other possible predator–prey interactions points toR. rattusas an efficient consumer ofS. salamandrain these insular environments, which might exert a high predation pressure on both islands. Yet, the drivers underlying the behavioural and phenotypic differences in these insular populations should be further investigated.
Effect of dapagliflozin in patients with diabetes and heart failure with mildly reduced or preserved ejection fraction according to background glucose‐lowering therapy: A pre‐specified analysis of the DELIVER trial
Authors: Lassen Mats Christian Højbjerg , Ostrominski John W. , Inzucchi Silvio E. , Claggett Brian L. , Kulac Ian , Jhund Pardeep , de Boer Rudolf A. , Hernandez Adrian F. , Kosiborod Mikhail N. , Lam Carolyn S.P. , Martinez Felipe A. , Shah Sanjiv J. , Desai Akshay S. , Petersson Magnus , Langkilde Anna Maria , Docherty Kieran F. , McMurray John J.V. , Solomon Scott D. , Vaduganathan Muthiah 
Published: May 2024

AimsType 2 diabetes (T2D) and heart failure (HF) frequently coexist, but whether clinical outcomes and treatment effects of sodium–glucose cotransporter 2 inhibitors (SGLT2i) vary in relation to background glucose‐lowering therapy (GLT) in this population is uncertain.Methods and resultsDELIVER randomized patients with HF and left ventricular ejection fraction (LVEF) >40% to dapagliflozin or placebo. The primary outcome was a composite of worsening HF (HF hospitalization or urgent HF visit) or cardiovascular death. In this pre‐specified analysis of participants with T2D, treatment effects were assessed by number and class of background GLT(s). Of 3150 participants with T2D at baseline, 22.9% were on no GLT, 36.5% were treated with 1 GLT, and 40.6% with ≥2 GLTs. During follow‐up (median: 2.3 years), treatment benefits of dapagliflozin (vs. placebo) on the primary outcome were consistent irrespective of the number of background GLTs (0 GLTs: hazard ratio [HR] 0.71, 95% confidence interval [CI] 0.50–1.00; 1 GLT: HR 1.04, 95% CI 0.80–1.34; ≥2 GLTs: HR 0.71, 95% CI 0.56–0.90; pinteraction = 0.59). Similar findings were observed among participants with (HR 0.73, 95% CI 0.59–0.92) and without background metformin use (HR 0.89, 95% CI 0.72–1.11; pinteraction = 0.22) and in participants with (HR 0.89, 95% CI 0.69–1.16) and without background insulin use (HR 0.78, 95% CI 0.65–0.95; pinteraction = 0.45). Dapagliflozin was well‐tolerated irrespective of the number of background GLTs.ConclusionsDapagliflozin safely and consistently improved clinical outcomes among individuals with T2D and HF with LVEF >40% irrespective of the number and class of background GLTs, and the benefits were not influenced by concomitant metformin or insulin use. These data bolster contemporary guidelines supporting first‐line SGLT2i among individuals with T2D and HF, irrespective of background GLT.
On‐treatment analysis of torsemide versus furosemide for patients hospitalized for heart failure: A post‐hoc analysis of TRANSFORM‐HF
Authors: Kittipibul Veraprapas , Mentz Robert J. , Clare Robert M. , Wojdyla Daniel M. , Anstrom Kevin J. , Eisenstein Eric L. , Ambrosy Andrew P. , Goyal Parag , Skopicki Hal A. , Ketema Fassil , Kim Dong‐Yun , Desvigne‐Nickens Patrice , Pitt Bertram , Velazquez Eric J. , Greene Stephen J. 
Published: May 2024

ABSTRACTAimThe TRANSFORM‐HF trial demonstrated no significant outcome differences between torsemide and furosemide following hospitalization for heart failure (HF), but may have been impacted by non‐adherence to the randomized diuretic. The current study sought to determine the treatment effect of torsemide versus furosemide using an on‐treatment analysis inclusive of all randomized patients except those confirmed non‐adherent to study diuretic.Methods and resultsTRANSFORM‐HF was an open‐label, pragmatic randomized trial of 2859 patients hospitalized for HF from June 2018 through March 2022. Patients were randomized to a loop diuretic strategy of torsemide versus furosemide with investigator‐selected dosage. This post‐hoc on‐treatment analysis included all patients alive with either known or unknown diuretic status, and excluded patients confirmed to be non‐adherent to study diuretic. This modified on‐treatment definition was applied separately at time of hospital discharge and 30‐day follow‐up. All‐cause mortality and hospitalization outcomes were assessed over 12 months. Overall, 2570 (89.9%) and 2374 (83.0%) patients were included in on‐treatment analyses at discharge and 30‐day follow‐up, respectively. There was no significant difference in all‐cause mortality between torsemide and furosemide in patients on‐treatment at discharge (17.5% vs. 17.8%; hazard ratio [HR] 1.01 [95% confidence interval [CI] 0.83–1.22], p = 0.96) and at 30‐day follow‐up (14.5% vs. 15.0%; HR 1.02 [95% CI 0.81–1.27], p = 0.90). All‐cause mortality or all‐cause hospitalization was similar between torsemide and furosemide in patients who were on‐treatment at discharge (58.3% vs. 61.3%; HR 0.92 [95% CI 0.82–1.03]) and 30‐day follow‐up (60.9% vs. 64.4%; HR 0.93 [95% CI 0.82–1.05]). In patients who were on‐treatment at 30‐day follow‐up, there were 677 total hospitalizations in the torsemide group and 686 total hospitalizations in the furosemide group (rate ratio 0.99 [95% CI 0.86–1.14], p = 0.87).ConclusionsIn TRANSFORM‐HF, a post‐hoc on‐treatment analysis did not meaningfully differ from the original trial results. Among those deemed compliant with the assigned diuretic, there remained no significant difference in mortality or hospitalization after HF hospitalization with a strategy of torsemide versus furosemide.Clinical Trail Registration: ClinicalTrials.gov Identifier: NCT03296813.
Definitions and surveillance methods of running‐related injuries: A scoping review
Authors: Lacey Aisling , Whyte Enda , Dillon Sarah , O’Connor Siobhán , Burke Aoife , Moran Kieran 
Published: May 2024

AbstractInconsistent and restricted definitions of injury have contributed to limitations in determining injury rates and identifying risk factors for running‐related injuries (RRIs). The aim of this scoping review was to investigate the definitions and surveillance methods of RRIs. A systematic electronic search was performed using PubMed, Scopus, SPORTDiscuss, MEDLINE, and Web of Science databases. Included studies were published in English between January 1980 and June 2023 which investigated RRIs in adult running populations, providing a definition for a general RRI. Results were extracted and collated. 204 articles were included. Three primary criteria were used to define RRIs: physical description, effect on training and medical intervention, while three secondary criteria are also associated with definitions: cause/onset of injury, location, and social consequences. Further descriptors and sub‐descriptors form these criteria. The use of Boolean operators resulted in nine variations in definitions. Inconsistency is evident among definitions of RRIs. Injury definitions seem to be important for two main reasons: firstly, determining accurate injury rates, and secondly, in research examining risk factors. For the latter, definitions seem to be very limited, only capturing severe injuries and failing to recognise the full development process of RRIs, precluding the identification of conclusive risk factors. A potential two‐approach solution is the initial use of a broad definition acting as a gatekeeper for identifying any potential injury, and follow‐up with an extensive surveillance tool to capture the specific consequences of the varying severity of RRIs.
Aerobic high‐intensity interval training and maximal strength training in patients with unspecific musculoskeletal disorders improve V̇O2peak and maximal strength more than moderate training
Authors: Hov Håkon , Eithun Geir , Wang Eivind , Helgerud Jan 
Published: May 2024

AbstractImproving peak oxygen uptake (V̇O2peak) and maximal strength are key objectives of rehabilitation for patients with unspecific musculoskeletal disorders (MSDs). Although high‐intensity training yield superior outcomes for these factors, patients with MSDs may not tolerate high‐intensity due to pain and fear. Therefore, we examined the effect and feasibility of incorporating aerobic high‐intensity intervals (HIITs) and maximal strength training (MST) in a standard clinical rehabilitation program for patients with unspecific MSDs. 73 patients (45 ± 10 years) with MSDs partaking in a standard, public, and 4‐week rehabilitation program were randomized to high‐intensity training (HG: 4 × 4 minutes intervals at ∼90% of maximal heart rate; HRmax, and 4 × 4 repetitions leg press at ∼90% of 1 repetition maximum; 1RM, with maximal intended velocity) or keep todays treatment of low‐to moderate‐intensity training (MG: various cycling, walking, and/or running activities at ∼70%–80% of HRmax and 3 × 8 − 10 repetitions leg press at ∼75% of 1RM without maximal intended velocity). HG improved V̇O2peak (12 ± 7%) and leg press 1RM (43 ± 34%) more than moderate‐intensity group (V̇O2peak; 5 ± 6%, 1RM; 19 ± 18%, both p < 0.001). We observed that no adverse events and no between‐group differences in dropout rate or self‐reported quality of life (both p > 0.05). There were positive correlations between improved V̇O2peak and improved physical (p = 0.024) and emotional (0.016) role functioning. We conclude that both high‐intensity interval training and MST are feasible and improve V̇O2peak and maximal strength more than standard low‐to moderate‐intensity treatment of patients with unspecific MSDs. Our findings suggest that high‐intensity training should be implemented as a part of standard clinical care of this patient population.
Lattice Boltzmann simulation of effects of realistic boundary conditions on volumetric radiation‐conduction melting of a novel cylindrical enclosure filled with phase change materials
Authors: Zameni‐Ghalati Saeideh , Mehryar Reza , Imani Gholamreza 
Published: May 2024

AbstractIn this research, a novel solar latent heat thermal energy storage (LHTES) system, including the cylindrical enclosures filled with a phase change material (PCM), is proposed, which can be installed on the building windows to alleviate the drawbacks of traditional PCM‐filled double‐glazed windows, such as daylight hindrance and leakage. The lattice Boltzmann method (LBM) is used to simulate the volumetric radiation‐conduction melting of the PCM within a single cylinder of the proposed LHTES system with considering more realistic conditions such as convective boundary condition, shadow effect, and variable solar radiation angle compared with the available works in the literature. As such, several boundary conditions are assessed, and parameters such as cylinder diameter, extinction coefficient, scattering albedo, solar angle, shadow effect, and natural convection heat transfer coefficient are studied on the time history of the melting fraction and charging time. The results revealed that considering the applied conditions, such as convection heat loss to the environment and shadow, significantly affects the charging time of the system. It is shown that the charging time for convective boundary condition with , , and increases, respectively, by 11%, 30%, and 50% relative to a case with the insulated boundary condition without the shadow effect and 38%, 91%, and 175% compared with the insulated case with a 90° shadow.
Adulteration detection of edible oil by one‐class classification and outlier detection
Authors: Dou Xinjing , Tu Fengqin , Yu Li , Yang Yong , Ma Fei , Wang Xuefang , Wang Du , Zhang Liangxiao , Jiang Xiaoming , Li Peiwu 
Published: May 2024

AbstractEdible oil adulteration is a mostly practiced phenomenon. However, the traditional discriminant methods fail to detect oil adulteration involving more than one adulterant. Recently, one‐class classifiers were built for food or oil authentication. Unfortunately, as it is hard to determine the application domain of the one‐class classifier, high prediction error was obtained for real samples in market surveillance. In this study, a new method was developed based on one‐class classification and outlier detection for edible oil adulteration detection in market surveillance. The model population was constructed using Monte Carlo sampling of unidentified inspected samples to select the plateau region exhibiting the highest accumulated absolute centered residual (ACR) values. Subsequently, the number of models in the plateau region was validated by the theoretical ones calculated by the classical probability model. The models in the plateau region with the highest cumulative accumulated ACR values were used to identify adulterated oils. Furthermore, the cross‐validation was conducted by comparing identification results from two different Monte Carlo sampling ratios to ensure the accuracy of our method. Both single adulteration and multiple adulteration of peanut oils were prepared to validate our method. Moreover, this method was used to detect adulteration of sesame oils, which have already been identified by the markers in our previous study. The validation results of three datasets indicated that this method could effectively identify adulterated samples and therefore provide a novel solution for inspecting potential adulteration in practice.
Prevotella copri—a potential next‐generation probiotic
Authors: Zang Xiaojie , Xiao Meifang , Yu Leilei , Chen Ying , Duan Hui , Zhang Chengcheng , Zhao Jianxin , Narbad Arjan , Chen Wei , Tian Fengwei , Zhai Qixiao 
Published: May 2024

AbstractPrevotella copri, which is divided into four clades, exerts bidirectional effects on host health. These effects include positive improvements in the allergy response and insulin sensitivity. However, P. copri sometimes has adverse effects on host health, and it has been found to be positively correlated with inflammation, insulin resistance, and diarrhea. The interaction between P. copri and these diseases is influenced by the host's diet. The capacity of P. copri to metabolize dietary glycans, as well as the effects of its degradation products, such as short‐chain fatty acids and succinic acid, appear to underlie its dual impact on the host. This duality suggests that manipulating the host's diet to increase the abundance of P. copri may be an effective strategy to improve disease outcomes. Here, we illustrate the characteristics and genetic traits of P. copri related to dietary metabolism are and summarize the health effects of P. copri on the host and methods to regulate its abundance, thus providing suggestions for the development and practical application of P. copri.
Forecasting tail risk of skewed financial returns having exponential‐polynomial tails
Authors: Antwi Albert , Gyamfi Emmanuel N. , Adam Anokye M. 
Published: May 2024

AbstractAggregated long and short trading risk positions of speculative assets over time are likely to be unequal. This may be because of irrational decisions of traders and investors as well as catastrophic events that lead to pronounce or salient market crashes. Returns of such assets are therefore more likely to have one polynomial tail and one exponential tail. The generalized hyperbolic (GH) skewed Student‐t distribution is known to handle such situations quite well. In this paper, we use generalized autoregressive conditional heteroscedasticity (GARCH) models to empirically show the superiority of the GH skewed Student‐t distribution in forecasting the extreme tail risks of cryptocurrency returns in the presence of substantial skewness in comparison with some competing distributions. Furthermore, we show the practical significance of the GH skewed Student‐t distribution‐based risk forecasts in computing daily capital requirements. Evidence from the study suggests that the GH skewed Student‐t distribution model tends to be superior in forecasting volatility and expected shortfall (ES) but not value‐at‐risk. In addition, the distribution yields higher value‐at‐risk (VaR) exceptions but surprisingly avoids the red zone of the Basel II accord penalty zones and produces lower but optimal daily capital requirements. Therefore, in the presence of substantially skewed returns having exponential‐polynomial tails, we recommend the use of the GH skewed Student‐t distribution for parametric GARCH models in forecasting extreme tail risk.