bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paraganglioma of the endolarynx: a rare tumor in an uncommon location
Authors: Smolarz Joseph R , Hanna Ehab Y , Williams Michelle D , Kupferman Michael E 
Published: January 2010

Abstract

Background
Less than 80 reported cases of paragangliomas of the larynx are reported in the literature. A role for external beam radiation in this disease has not yet been explored. We present four cases of laryngeal paragangliomas treated at a large tertiary-care cancer center over a 35-year period.

Methods
124 cases of head and neck paragangliomas treated at a single institution from 1970 to 2005 were retrospectively studied. Patients with laryngeal paragangliomas were identified, and a comprehensive clinico-pathological review was undertaken.

Results
We identified 4 patients with tumors arising in the larynx at the following subsites: supraglottis (2), glottis (1), and subglottis (1). Three patients were treated with surgery and one with definitive radiation alone.

Conclusions
Laryngeal paragangliomas are rare tumors and are adequately treated with surgical resection. We also present one patient who was treated with radiation and had disease stabilization. Accurate histological classification is critical, and the role of genetic testing is emerging.
Basolateral NBCe1 plays a rate-limiting role in transepithelial intestinal HCO3– secretion, contributing to marine fish osmoregulation
Authors: Taylor J. R. , Mager E. M. , Grosell M. 
Published: January 2010

SUMMARYAlthough endogenous CO2 hydration and serosal HCO3– are both known to contribute to the high rates of intestinal HCO3– secretion important to marine fish osmoregulation, the basolateral step by which transepithelial HCO3– secretion is accomplished has received little attention. Isolated intestine HCO3– secretion rates, transepithelial potential (TEP) and conductance were found to be dependent on serosal HCO3– concentration and sensitive to serosal DIDS. Elevated mucosal Cl– concentration had the unexpected effect of reducing HCO3– secretion rates, but did not affect electrophysiology. These characteristics indicate basolateral limitation of intestinal HCO3– secretion in seawater gulf toadfish, Opsanus beta. The isolated intestine has a high affinity for serosal HCO3– in the physiological range (Km=10.2 mmol l–1), indicating a potential to efficiently fine-tune systemic acid–base balance. We have confirmed high levels of intestinal tract expression of a basolateral Na+/HCO3– cotransporter of the electrogenic NBCe1 isoform in toadfish (tfNBCe1), which shows elevated expression following salinity challenge, indicating its importance in marine fish osmoregulation. When expressed in Xenopus oocytes, isolated tfNBCe1 has transport characteristics similar to those in the isolated tissue, including a similar affinity for HCO3– (Km=8.5 mmol l–1). Reported affinity constants of NBC1 for Na+ are generally much lower than physiological Na+ concentrations, suggesting that cotransporter activity is more likely to be modulated by HCO3– rather than Na+ availability in vivo. These similar functional characteristics of isolated tfNBCe1 and the intact tissue suggest a role of this cotransporter in the high HCO3– secretion rates of the marine fish intestine.
Use of an alarm pheromone against ants for gaining access to aphid/scale prey by the red velvet miteBalaustiumsp. (Erythraeidae) in a honeydew-rich environment
Authors: Yoder Jay A. , Condon Michael R. , Hart Chloé E. , Collier Matthew H. , Patrick Kevin R. , Benoit Joshua B. 
Published: January 2010

SUMMARYThis study shows that honeydew prompts arrestment and reduced activity, but not attraction, by the mite Balaustium sp. nr. putmani. When presented with short-range, two-choice bioassays, mites ceased their characteristic rapid crawling activity when they encountered honeydew-treated surfaces, resulting in them clustering around the honeydew. Approximately 80% of mites were retained by honeydew, with responses being independent of both mite life-history stage and source of honeydew (coccid scale insect or aphid). No obvious crawling movements or redirection of running path were made to the honeydew by the mites, implying the lack of any kind of attractant. Response of mites to single-sugar presentations of the main honeydew components – glucose, sucrose, fructose and trehalose – (0.001–0.1 mmol l–1) were inconsistent and failed to reproduce the arrestment/clustering associated with raw honeydew, suggesting that none of these sugars is an active arrestant ingredient. Formation of feeding clusters on honeydew does not contribute to enhancing water conservation by suppressing net transpiration (water loss) rates of individual mites as group size increases, indicating that the clustering is an artifact of arrestment. We hypothesize that release of neryl formate by the mites reduces negative interactions with the local ant species commonly associated with honeydew. We hypothesize that honeydew serves as: (1) a cue that facilitates discovery of scale/aphid prey; (2) a retainer on plants where these prey are present, signaling abundance and quality; and (3) an alternative and supplemental food source like that noted for other plant-inhabiting predatory mites. Neryl formate serves as an alarm pheromone and foul-tasting allomonal defense secretion that prevents predation of mites by ants that co-exist with aphid/scale insects in these honeydew-rich habitats.
Muscle coordination is key to the power output and mechanical efficiency of limb movements
Authors: Wakeling J. M. , Blake O. M. , Chan H. K. 
Published: January 2010

SUMMARYThe purpose of this study was to determine which features of muscle mechanics and muscle coordination affect the power output from a limb during locomotion. Eight subjects were tested while cycling at maximum exertion for 25 min on a stationary dynamometer. Cadence and load were varied to span a range of power outputs and myoelectric activity was measured from 10 muscles in the leg. Cycle-by-cycle variations in muscle coordination, cadence and power output were observed and the EMG intensity across all muscles was used as an estimate of the metabolic cost for each cycle. Data for the cycles at greatest power output were separated into three groups: maximum power, 80% power but lower EMG intensity and 80% power and higher EMG intensity. Torque–angular velocity relations were determined for the ankle and knee joints. During cycling at maximum power output the ankle joint was not extending at the velocity necessary for maximum power output; thus, maximum limb power occurs when some of the individual muscles cannot be generating maximum power output. Increases in EMG intensity occurred with no increase in power output from the limb: these corresponded to decreases in the efficiency and changes in coordination. Increases in power were achieved that were not matched by equivalent increases in EMG intensity, but did occur with changes in coordination. It is proposed that the power output from the limb is limited by the coordination pattern of the muscles rather than the maximum power output from any one muscle itself.
Temperature acclimation alters oxidative capacities and composition of membrane lipids without influencing activities of enzymatic antioxidants or susceptibility to lipid peroxidation in fish muscle
Authors: Grim J. M. , Miles D. R. B. , Crockett E. L. 
Published: January 2010

SUMMARYCold acclimation of ectotherms results typically in enhanced oxidative capacities and lipid remodeling, changes that should increase the risk of lipid peroxidation (LPO). It is unclear whether activities of antioxidant enzymes may respond in a manner to mitigate the increased potential for LPO. The current study addresses these questions using killifish (Fundulus heteroclitus macrolepidotus) and bluegill (Lepomis macrochirus) acclimated to 5 and 25°C for 9 days and 2 months, respectively. Because the effects of temperature acclimation on pro- and antioxidant metabolism may be confounded by variable activity levels among temperature groups, one species (killifish) was also subjected to a 9-day exercise acclimation. Oxidative capacity of glycolytic (skeletal) muscle (indicated by the activity of cytochrome c oxidase) was elevated by 1.5-fold in killifish, following cold acclimation, but was unchanged in cardiac muscle and also unaffected by exercise acclimation in either tissue. No changes in citrate synthase activity were detected in either tissue following temperature acclimation. Enzymatic antioxidants (catalase and superoxide dismutase) of either muscle type were unaltered by temperature or exercise acclimation. Mitochondria from glycolytic muscle of cold-acclimated killifish were enriched in highly oxidizable polyunsatured fatty acids (PUFA), including diacyl phospholipids (total carbons:total double bonds) 40:8 and 44:12. Increased oxidative capacity, coupled with elevated PUFA content in mitochondria from cold-acclimated animals did not, however, impact LPO susceptibility when measured with C11-BODIPY. The apparent mismatch between oxidative capacity and enzymatic antioxidants following temperature acclimation will be addressed in future studies.
Exposure to cold but not exercise increases carbon turnover rates in specific tissues of a passerine
Authors: Bauchinger U. , Keil J. , McKinney R. A. , Starck J. M. , McWilliams S. R. 
Published: January 2010

SUMMARY
Carbon turnover differs between tissues within an animal, but the extent to which ecologically relevant increases in metabolism affect carbon turnover rates is largely unknown. We tested the energy expenditure and protein turnover hypotheses that predict increased carbon turnover, either in association with increased daily energy expenditure, or in concert with tissue-specific increased protein metabolism. We used stable-isotope-labeled diets to quantify the rate of carbon turnover in 12 different tissues for three groups of zebra finches (Taeniopygia guttata): cold-exposed birds kept at ambient temperatures below their thermoneutral zone, exercised birds that were flown for 2 h per day in a flight arena, and control birds that were kept at ambient temperatures within their thermoneutral zone and that were not exercised. We found that increases in metabolism associated with cold-exposure but not exercise produced measurable increases in carbon turnover rate of, on average, 2.4±0.3 days for pectoral muscle, gizzard, pancreas and heart, even though daily energy intake was similar for exercised and cold-exposed birds. This evidence does not support the energy expenditure hypothesis, and we invoke two physiological processes related to protein metabolism that can explain these treatment effects: organ mass increase and tissue-specific increase in activity. Such changes in carbon turnover rate associated with cold temperatures translate into substantial variation in the estimated time window for which resource use is estimated and this has important ecological relevance.
Energy storage and synchronisation of hind leg movements during jumping in planthopper insects (Hemiptera, Issidae)
Authors: Burrows M. 
Published: January 2010

SUMMARYThe hind legs of Issus (Hemiptera, Issidae) move in the same plane underneath the body, an arrangement that means they must also move synchronously to power jumping. Moreover, they move so quickly that energy must be stored before a jump and then released suddenly. High speed imaging and analysis of the mechanics of the proximal joints of the hind legs show that mechanical mechanisms ensure both synchrony of movements and energy storage. The hind trochantera move first in jumping and are synchronised to within 30 μs. Synchrony is achieved by mechanical interactions between small protrusions from each trochantera which fluoresce bright blue under specific wavelengths of ultra-violet light and which touch at the midline when the legs are cocked before a jump. In dead Issus, a depression force applied to a cocked hind leg, or to the tendon of its trochanteral depressor muscle causes a simultaneous depression of both hind legs. The protrusion of the hind leg that moves first nudges the other hind leg so that both move synchronously. Contractions of the trochanteral depressor muscles that precede a jump bend the metathoracic pleural arches of the internal skeleton. Large areas of these bow-shaped structures fluoresce bright blue in ultraviolet light, and the intensity of this fluorescence depends on the pH of the bathing saline. These are key signatures of the rubber-like protein resilin. The remainder of a pleural arch consists of stiff cuticle. Bending these composite structures stores energy and their recoil powers jumping.
Seasonality of torpor patterns and physiological variables of a free-ranging subtropical bat
Authors: Stawski C. , Geiser F. 
Published: January 2010

SUMMARYSeasonal changes in weather and food availability differ vastly between temperate and subtropical climates, yet knowledge on how free-ranging subtropical insectivorous bats cope with such changes is limited. We quantified ambient temperatures, torpor patterns and thermal physiology of subtropical insectivorous northern long-eared bats, Nyctophilus bifax, during summer (n=13) and winter (n=8) by temperature telemetry. As predicted, ambient conditions varied significantly between seasons, with warmer weather during summer. All bats used torpor on 85% of observation days during summer in comparison to 100% during winter. During summer, patterns of torpor varied and the duration of torpor bouts was not significantly affected by ambient temperature, whereas during winter torpor bout duration was negatively correlated with mean ambient temperature. Mean torpor bout duration in summer was 3.2±1.3 h and in winter was 26.8±11.3 h. Mean arousal time during summer was in the early afternoon and during winter in the late afternoon, and throughout both seasons arousals for possible foraging periods occurred near sunset. Skin temperature was positively correlated with ambient temperatures in both seasons, but the relationship differed between seasons. We show that torpor is used regularly throughout the year in a free-ranging subtropical bat and provide the first evidence demonstrating that torpor patterns and thermal physiology change with season.
Function of the appendages in tentacled snakes (Erpeton tentaculatus)
Authors: Catania K. C. , Leitch D. B. , Gauthier D. 
Published: January 2010

SUMMARYWe investigated the function of the tentacles in aquatic, piscivorous tentacled snakes (Erpeton tentaculatus) by examining anatomy, peripheral innervation, and the response properties of primary afferents. We also investigated visual and somatosensory responses in the optic tectum and documented predatory strikes to visual stimuli and under infrared illumination. Our results show the tentacles are sensitive mechanoreceptors that respond to water movements. They are innervated by rami of the maxillary and ophthalmic branches of the trigeminal nerve and contain a dense array of fine terminal neurites that cross the interior of the tentacle orthogonal to its long axis. The optic tectum contained a retinotopic map of contralateral receptive fields with superior fields represented dorsally in the tectum, inferior fields represented laterally, nasal fields represented rostrally, and temporal fields represented caudally. Large somatosensory receptive fields were identified in deeper layers of the tectum and were in approximate register with overlying visual fields. Tentacled snakes struck accurately at a simulated digital fish, indicating that visual cues are sufficient to guide strikes, but they also captured fish under infrared illumination, suggesting water movements alone could be used to localize prey. We conclude the tentacles are mechanosensors that are used to detect fish position based on water movements and that visual and mechanosensory cues may be integrated in the tectum to enhance localization when visual cues are reduced.
Carbohydrate absorption by blackcap warblers (Sylvia atricapilla) changes during migratory refuelling stopovers
Authors: Tracy C. R. , McWhorter T. J. , Wojciechowski M. S. , Pinshow B. , Karasov W. H. 
Published: January 2010

SUMMARY
Passerine birds migrating long distances arrive at stopover sites to refuel having lost as much as 50% of their initial body mass (mb), including significant losses to digestive organs that may serve as a reservoir of protein catabolised for fuel during flight. Birds newly arrived at a stopover show slow or no mb gain during the initial 2–3 days of a stopover, which suggests that energy assimilation may be limited by reduced digestive organs. Measurements of migrants and captive birds subjected to simulated migratory fasts have shown reductions in intestine mass, morphological changes to the mucosal epithelium, and reductions in food intake and assimilation rate upon initial refeeding. We found that blackcaps (Sylvia atricapilla, Linnaeus) newly arrived at a migratory stopover after crossing the Sahara and Sinai deserts had significantly increased paracellular nutrient absorption (non-carrier mediated uptake occurring across tight junctions between enterocytes) that may provide partial compensation for reduced digestive capacity resulting from changes to intestinal tissues. Indeed, newly arrived birds also had a slightly reduced capacity for absorption of a glucose analogue (3-O-methyl-d-glucose) transported simultaneously by both carrier-mediated and non-mediated mechanisms. Increased paracellular absorption coupled with extended digesta retention time may thus allow migratory blackcaps to maintain high digestive efficiency during initial stages of refuelling while digestive organs are rebuilt.
Beethoven's Political Music, the Handelian Sublime, and the Aesthetics of Prostration
Authors: Mathew Nicholas 
Published: January 2010

Abstract
This article argues for a number of hitherto unrecognized continuities—stylistic, aesthetic, and ideological—between Beethoven's marginalized “political music” from the period of the Congress of Vienna and his canonical symphonic works. It rereads his œuvre against the background of the popularity and ubiquity of the “Handelian sublime” in early-nineteenth-century Viennese public life—that is, the aesthetics and social practice of grand choral singing, associated primarily with some of Handel's oratorios, but also with the late choral works of Haydn. Presenting new archival research into Vienna's politicized choral culture, the article argues that contemporary theorizing about the power of the musical sublime became the theoretical wing of music's changing social status, as it was mobilized by the state during the Napoleonic Wars more than ever before. These new, Handelian contexts for Beethoven's music lead to three conclusions. First, the choral aesthetic background to Beethoven's symphonies has been largely overlooked. With reference to original performance contexts as well as the topical character of Beethoven's symphonies, the article argues that the symphonies are often best understood as orchestral transmutations of the grand Handelian chorus. Against this background, the appearance of an actual chorus in the Ninth might be reconceived as a moment when the genre's aesthetic debt is most apparent, rather than a shocking generic transgression. Second, the distinction, commonly elaborated by Beethoven scholars, between the mere bombast of Beethoven's political compositions and the “authentic,” Kantian sublime of human freedom supposedly articulated in his symphonies cannot easily be sustained. Third, the cultural entanglement of choral and symphonic music in Beethoven's Vienna reveals something not only of the political origins but also of the continuing political potency of Beethoven's symphonies. With reference to Althusserian theories of power and subjectivity, the article speculates that the compelling sense of listener subjectivity created by Beethoven's most vaunted symphonic compositions (noted by Scott Burnham) comes about in part through the music's and the listener's transformation of external, choral reflections of political power into internal, symphonic ones—a transformation that leaves its mark on the topical character of the symphonies, which, especially in their most intense moments of subjective engagement, are replete with official topics and gestures: marches, hymns, and fugues. This might explain why the music has so often been heard as simultaneously browbeating and uplifting, authoritarian and liberating.
Parsifal's Aura
Authors: Meyer Stephen C. 
Published: January 2010

Abstract
“Aura”—configured as an interplay of preservation and loss or—to quote the first version of Walter Benjamin's famous artwork essay—as an “interweaving of space and time”—is central not only to sound recording, but also to the musical dramaturgy of Wagner's final work. This article examines ways in which this unusual alignment affected early (pre-1948) recordings of Parsifal. The potential contradictions implicit in the concept of aura are nowhere more strikingly revealed than in these early recordings. On one hand, they foreground the problems of reducing complex and lengthy works to easily recorded excerpts or arrangements. In this quasi-Adornian reading, early sound recordings of Parsifal manifest the inexorable power of the culture industry to undermine the authentic work of art. And yet sound recording can also be seen as the fruit of a different impulse, the impulse toward a fully transcendent work of art, the realization of the “invisible theater” for which Wagner himself supposedly yearned. Indeed, Parsifal (even more than Wagner's other works) was recorded primarily as a symphonic work, divested of what Adorno so tellingly called the “phony hoopla” of operatic production. Early sound recording of Parsifal thus amplifies the conflict between materialism and transcendence that forms the ideological substratum of the plot. This conflict manifests itself in the “resistance” that Parsifal offers up to the process of recording, a resistance that is ironically most audible precisely during the age in which the recordings themselves are most “imperfect.” It is in these traces of resistance, I will argue, that we may imagine the aura of Wagner's final work.
“Das verlassene Mägdlein”: Grief Partaken
Authors: Bottge Karen M. 
Published: January 2010

Abstract
Perhaps the most influential abandoned woman to surface in the musical history of the nineteenth century was that conceived by Biedermeier poet Eduard Mörike. Since its initial publication in 1832, his “Das verlassene Mägdlein” has engaged the sustained attention of composers, performers, and even music analysts and critics. Not only did his Mägdlein prompt the creation of numerous nineteenth-century volkstümliche varianten throughout Germany and Austria, but she also inspired 130 musical settings dating between 1832 and 1985. Yet, although Mörike is just one of many figures within a long tradition of male poets writing on female abandonment, there seems to be something to this particular poem, that is, to Mörike's Mägdlein, that has compelled composers to retell her tale again and again in song. My discussion begins by first revisiting the poem's original novelistic context, Maler Nolten: Novelle in zwei Theilen (1832). Thereafter I follow Mörike's Mägdlein from her poetic beginnings to two of her best-known musical reappearances: Robert Schumann's “Das verlassne Mägdelein” (op. 64, no. 2) of 1847 and the work it inspired forty years later, Hugo Wolf's 1888 “Das verlassene Mägdlein” (also op. 64, no. 2), perhaps the most renowned setting of them all. Through the juxtaposition of these two settings we may not only uncover their potential textual and musical interconnections, but also gain insight into the tacit cultural understandings and ideologies surrounding those who take up the voice of the abandoned.