bluuebunny/crossref_metadata_2025_split huggingface dataset:
X‐ray and Solution Structures of CuIIGHK and CuIIDAHK Complexes: Influence on Their Redox Properties
Authors: Hureau Christelle , Eury Hélène , Guillot Régis , Bijani Christian , Sayen Stéphanie , Solari Pier‐Lorenzo , Guillon Emmanuel , Faller Peter , Dorlet Pierre 
Published: July 2011

AbstractThe Gly‐His‐Lys (GHK) peptide and the Asp‐Ala‐His‐Lys (DAHK) sequences are naturally occurring high‐affinity copper(II) chelators found in the blood plasma and are hence of biological interest. A structural study of the copper complexes of these peptides was conducted in the solid state and in solution by determining their X‐ray structures, and by using a large range of spectroscopies, including EPR and HYSCORE (hyperfine sub‐level correlation), X‐ray absorption and 1H and 13C NMR spectroscopy. The results indicate that the structures of [CuII(DAHK)] in the solid state and in solution are similar and confirm the equatorial coordination sphere of NH2, two amidyl N and one imidazole N. Additionally, a water molecule is bound apically to CuII as revealed by the X‐ray structure. As reported previously in the literature, [CuII(GHK)], which exhibits a dimeric structure in the solid state, forms a monomeric complex in solution with three nitrogen ligands: NH2, amidyl and imidazole. The fourth equatorial site is occupied by a labile oxygen atom from a carboxylate ligand in the solid state. We probe that fourth position and study ternary complexes of [CuII(GHK)] with glycine or histidine. The CuII exchange reaction between different DAHK peptides is very slow, in contrast to [CuII(GHK)], in which the fast exchange was attributed to the presence of a [CuII(GHK)2] complex. The redox properties of [CuII(GHK)] and [CuII(DAHK)] were investigated by cyclic voltammetry and by measuring the ascorbate oxidation in the presence of molecular oxygen. The measurements indicate that both CuII complexes are inert under moderate redox potentials. In contrast to [CuII(DAHK)], [CuII(GHK)] could be reduced to CuI around −0.62 V (versus AgCl/Ag) with subsequent release of the Cu ion. These complete analyses of structure and redox activity of those complexes gave new insights with biological impact and can serve as models for other more complicated CuII–peptide interactions.
Bacillus anthracis tubulin‐related protein Ba‐TubZ assembles force‐generating polymers
Authors: Srinivasan Ramanujam , Mishra Mithilesh , Leong Fong Yew , Chiam Keng‐Hwee , Balasubramanian Mohan 
Published: July 2011

AbstractPathogenicity of Bacillus anthracis depends on the faithful inheritance of plasmid pXO1, in a process that requires the plasmid encoded tubulin‐related protein Ba‐TubZ. Here we show, using heterologous expression in Schizosaccharomyces pombe, that Ba‐TubZ assembles into a dynamic polymer in the absence of other B. anthracis proteins and can generate force capable of deforming the fission yeast nuclear envelope. The polymer bundles contain 27 ± 15 protofilaments/μm assuming that each protofilament spans the entire length. Thinner appearing buckled and thicker appearing straight filaments of Ba‐TubZ were both capable of inducing nuclear envelope deformation. Unlike the related protein Bt‐TubZ from Bacillus thuringiensis, which undergoes treadmilling upon expression in fission yeast, Ba‐TubZ polymers did not undergo detectable treadmilling. Instead, in fluorescence recovery after photobleaching experiments, it displayed a different turnover behavior characterized by moderate fluorescence recovery along the entire length of the polymer. Modeling Ba‐TubZ bundles as Euler–Bernoulli beams that buckle under compressive loads when pushed against the nuclear envelope allowed us to estimate that Ba‐TubZ generates forces in the order of 1–10 nN. We propose that polymerization based filament elongation and force generation might aid faithful segregation of the virulence plasmid. © 2011 Wiley‐Liss, Inc.
Patient‐reported outcome measures suitable to assessment of patient navigation
Authors: Fiscella Kevin , Ransom Sean , Jean‐Pierre Pascal , Cella David , Stein Kevin , Bauer Joseph E. , Crane‐Okada Rebecca , Gentry Sharon , Canosa Rosalie , Smith Tenbroeck , Sellers Jean , Jankowski Emilia , Walsh Karyn 
Published: July 2011

AbstractBACKGROUND:Patient‐reported outcomes (PROs) are measures completed by patients to capture outcomes that are meaningful and valued by patients. To help standardize PRO measures in patient navigation research and program evaluation, the Patient‐Reported Outcomes Working Group (PROWG) was convened as part of the American Cancer Society's National Patient Navigator Leadership Summit.METHODS:The PROWG consisted of clinicians, researchers, and program managers from a variety of perspectives who developed a set of recommended PRO measures across the cancer continuum (ie, screening, diagnostic follow‐up, treatment, survivorship, end of life) as well as those useful for assessing family caregivers. Measures were recommended based on face validity, responsiveness to navigation, reliability, and construct validity in relevant populations. Other considerations included readability, existence of multiple language versions, the existence of norm groups, and respondent burden.RESULTS:The PROWG reached consensus on measures for use in the domains of treatment adherence; perceived barriers to care; satisfaction with cancer care; satisfaction with patient navigation services; working alliance with patient navigator; perceived knowledge/competence/self‐efficacy; functional assessment/symptom burden; global quality of life; specific quality‐of‐life symptoms (eg, depression, anxiety); and perceived cultural competency of the navigator. In domains where validated measures were found lacking, recommendations were made for areas of needed scale development.CONCLUSIONS:These measures should guide research and programmatic evaluation of patient navigation. Cancer 2011;117(15 suppl):3601–615. © 2011 American Cancer Society.
Redistribution of astrocytic glutamine synthetase in the hippocampus of chronic epileptic rats
Authors: Papageorgiou Ismini E. , Gabriel Siegrun , Fetani Andriani F. , Kann Oliver , Heinemann Uwe 
Published: July 2011

AbstractGlutamine synthetase (GS) is an astrocytic enzyme, which catalyzes the synthesis of glutamine from glutamate and ammonia. In the central nervous system, GS prevents glutamate‐dependent excitotoxicity and detoxifies nitrogen. Reduction in both expression and activity of GS was reported in the hippocampus of patients with temporal lobe epilepsy (TLE), and this reduction has been suggested to contribute to epileptogenesis. In this study, we characterized hippocampal GS expression in the pilocarpine model of TLE in Wistar rats by means of stereology and morphometric analysis. Neither the GS positive cell number nor the GS containing cell volume was found to be altered in different hippocampal subregions of chronic epileptic rats when compared with controls. Instead, redistribution of the enzyme at both intracellular and tissue levels was observed in the epileptic hippocampus; GS was expressed more in proximal astrocytic branches, and GS expressing astrocytic somata was located in closer proximity to vascular walls. These effects were not due to shrinkage of astrocytic processes, as revealed by glial fibrillary acidic protein staining. Our results argue for GS redistribution rather than downregulation in the rat pilocarpine model of TLE. The potential contribution of increased GS perivascular affinity to the pathogenesis of epilepsy is discussed as well. © 2011 Wiley‐Liss, Inc.
Factors influencing survival of native and translocated mountain quail in Idaho and Washington
Authors: Stephenson John A. , Reese Kerry P. , Zager Peter , Heekin Patricia E. , Nelle Pamela J. , Martens Ashley 
Published: July 2011

AbstractUnderstanding survival and cause‐specific mortality of native and translocated animals can help biologists design more effective recovery programs. We estimated survival rates for 181 native mountain quail (Oreortyx pictus) in west‐central Idaho from 1992 to 1996 and for 199 translocated mountain quail in western Idaho and eastern Washington in 2005 and 2006. Spring–summer survival of native birds over 4 yr ranged from 0.210 (SE = 0.116) to 0.799 (SE = 0.103) and fall–winter survival in 2 yr was 0.523 (SE = 0.089) and 0.244 (SE = 0.084). Annual survival rates were 0.418 (SE = 0.088) and 0.174 (SE = 0.065). Spring–summer survival rate of translocated birds was 0.215 (SE = 0.044) in 2005 and 0.059 (SE = 0.021) in 2006. We modeled biweekly survival as a function of sex, age, movement rate, native versus translocated status, and linear time trend, and then we added year and 3 weather covariates (mean biweekly precipitation and maximum and minimum temperatures). Year and climate variables improved the a priori top model which included movement rate and native versus translocated status. Higher mortality rates due to predation coincided with movements to breeding habitat in late winter, periods of higher temperatures in the spring and summer, and periods of higher precipitation and colder temperatures during the fall–winter seasons. High movement rates of native birds in winter to avoid snow and by translocated birds when dispersing may have led to greater exposure to predators and consequently lower survival rates. Mountain quail can experience low and variable survival, stressing the potential need for multiple years of releases in restoration efforts in the eastern portion of their range. More attention is needed to identify optimal habitat (including nest sites) for restoring mountain quail populations to reduce movements, lower mortality risks, and provide conditions for withstanding periods of unfavorable weather. © 2011 The Wildlife Society.
High efficiency and high beam quality 3.467‐μm KTA extracavity optical parametric oscillator
Authors: Sun Qibing , Liu Hongjun , Huang Nan , Ruan Chi , Zhu Shaolan , Zhao Wei 
Published: July 2011

AbstractAn efficient single resonant extracavity optical parametric oscillator is demonstrated based on a Type II noncritical phase matching KTA crystal.Under a pump power of 0.6 W and a pulse width of 13 ns, the average power of 86 mW at 3.467 μm is obtained with the pulse width of 6 ns and repetition rate of 100 Hz, corresponding to a conversion efficiency as high as 14% from 1.064 to 3.467 μm. The beam spatial profile for 3.467 μm is near TEM00 mode. The average power of 123 mW is also obtained with a multitransverse mode at the repetition rate of 200 Hz and an average power of 2.3 W of the pump laser. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:2204–2207, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26247
Performances of a mid‐infrared CH4 detection device using an optimized asymmetric ellipse gas‐cell
Authors: Ye Wei‐Lin , Zheng Chuan‐Tao , Yu Xin , Song Zhan‐Wei , Wang Yi‐Ding 
Published: July 2011

AbstractWe demonstrate a mid‐infrared CH4 detection device using a novel fabricated asymmetric ellipse light‐collecting gas‐cell.Structural optimizations are performed for fast gas‐diffusion speed and high detection sensitivity. Detection experiments on standard CH4 samples show that the detection sensitivity is about 9 ppm within the concentration range 8˜1000 ppm, the minimum detection limit is about 8 ppm, and the 10˜90% response time is as fast as 6.0 s. This fabricated device with asymmetric gas‐cell reveals superior performances to the previous reported device with symmetric gas‐cell in our laboratory. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:2327–2330, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26282
Direct computation of critical equilibrium states for spatial beams and frames
Authors: Mäkinen Jari , Kouhia Reijo , Fedoroff Alexis , Marjamäki Heikki 
Published: July 2011

SUMMARYIn this paper, explicit formulas for second order derivatives of the residual vector with respect to the state variables for a geometrically exact 3D beam element based on the Reissner's model are presented. These derivatives are required when a direct non‐linear stability eigenvalue problem is solved by the Newton's method. If the external load is parametrized by a single parameter, such an eigenvalue problem consists of solving the critical state variables, the eigenmode, and the critical load parameter from the equation system consisting of the equilibrium equations, the criticality condition, and some auxiliary conditions depending on the type of a critical point. Copyright ©2011 John Wiley & Sons, Ltd.
Self‐perceived Work‐related Stress and its Relation to Salivary IgA, Cortisol and 3‐Methoxy‐4‐hydroxyphenyl Glycol Levels among Neonatal Intensive Care Nurses
Authors: Fujimaru Chihiro , Okamura Hisayoshi , Kawasaki Miho , Kakuma Tatsuyuki , Yoshii Chiho , Matsuishi Toyojiro 
Published: July 2011

AbstractThis study investigated self‐perceived work‐related stress, along with salivary IgA (s‐IgA), cortisol and 3‐methoxy‐4‐hydroxyphenyl glycol (MHPG) in 38 neonatal intensive care unit (NICU) nurses and 26 general ward (GW) nurses. To adjust for sociodemographic characteristics, the two groups of nurses were strictly matched for age, gender (feminine), average work experience and marital status (unmarried). General fatigue and anxiety were significantly higher, and depressive mood tended to be higher, in NICU nurses compared to GW nurses, based on Cumulative Fatigue Symptoms Index scores (p < 0.05, p < 0.05, p = 0.079, respectively). s‐IgA concentrations were also inversely correlated with self‐perceived work‐related stress and were significantly lower in NICU nurses than in GW nurses (p < 0.01). There tended to be a positive association between high cortisol concentrations and the CFSI subscale of depressive mood in both NICU and GW nurses (p = 0.053). Cortisol and MHPG levels were not different between NICU and GW nurses. These work‐related stress markers, both self‐perceived (CFSI) and biological (s‐IgAand cortisol concentrations), highlight the importance of creating and sustaining healthy work environments for NICU and GW nurses. Copyright © 2011 John Wiley & Sons, Ltd.
The introduction of lung stereotactic body radiotherapy in the UK… it’s now a reality!
Authors: Needham A , Hutton D , Baker A 
Published: July 2011

AbstractLung stereotactic body radiotherapy (SBRT) is a novel and effective technique for the treatment of early stage non small cell lung cancer which is rapidly becoming the radiotherapy regime of choice for those patients unable or unwilling to undergo surgical resection.Although introduced almost 20 years ago, it was not until the wider establishment of image guided radiotherapy (IGRT) techniques that many UK departments first considered and then succeeded in implementing lung SBRT. Many have been assisted in this through membership of the national UK SBRT consortium which aims to facilitate local introduction and to provide guidelines and practical support for the wider radiotherapy community.This article will seek to place the introduction of SBRT within a broad historical context, outline basic principles for safe and effective practice and describe how such principles are currently being pursued in an era of IGRT. Additionally, the role of the UK SBRT consortium in implementation will be reported alongside the results of its first national survey on the subject.
Between HIV diagnosis and initiation of antiretroviral therapy: assessing the effectiveness of care for people living with HIV in the public primary care service in Cape Town, South Africa
Authors: Scott Vera , Zweigenthal Virginia , Jennings Karen 
Published: July 2011

SummaryObjective  To assess the quality of pre‐antiretroviral therapy (ART) care in Cape Town and its continuity with HIV counselling and testing (HCT) and ART.Methods  The scale‐up of the HCT, pre‐ART and ART service platform and programmatic support in Cape was described. Data from the August 2010 routine annual HIV/TB/STI evaluation, which included interviews with 133 facility managers and folder reviews of 634 HCT clients who tested positive and 1115 clients receiving pre‐ART HIV care, were analysed.Results  Historically, the implementation and management of pre‐ART care has been relatively neglected compared with the scale‐up of HCT and ART. CD4 counts were carried out for 77.5% of positive HCT clients, and 46.6% were clinically staged – crucial steps that determine the care path. There were gaps in quality of care (32.2% of women had a PAP smear), missed opportunities for integrated care (67% were symptomatically screened for tuberculosis) and positive prevention (48.3% had contraceptive needs assessed). Breaks in the continuity of care of pre‐ART clients occurred with only 47.2% of eligible clients referred appropriately to the ARV service.Conclusion  While a package of pre‐ART care is clearly defined in Cape Town, it has not been fully implemented. There are weaknesses in the continuity and quality of service delivered that undermine the programme objectives of provision of positive prevention and timely access to ART.
EFFICACY OF ENDOSCOPIC SUBMUCOSAL RESECTION WITH A LIGATION DEVICE FOR REMOVING SMALL RECTAL CARCINOID TUMOR COMPARED WITH ENDOSCOPIC MUCOSAL RESECTION: ANALYSIS OF 100 CASES
Authors: KIM HYUNG HUN , PARK SEUN JA , LEE SANG HEON , PARK HEE UG , SONG CHUL SOO , PARK MOO IN , MOON WON 
Published: July 2011

Aim  Conventional endoscopic mucosal resection (EMR) of carcinoid tumors is often associated with involvement of the resection margin, which necessitates further intervention. Endoscopic submucosal resection with a ligation device (ESMR‐L) is a novel technique for the removal of carcinoid tumors. The aim of the present study was to compare the clinical usefulness of endoscopic submucosal resection with a ligation device with that of EMR for the complete resection of rectal carcinoid tumors.Methods  Between January 2001 and October 2010, a total of 100 patients with 100 rectal carcinoid tumors that were estimated to be 10 mm or less in diameter and that were resected either using ESMR‐L or EMR were recruited for this study. The complete resection rate and complications associated with these two procedures were analyzed.Results  Forty‐five out of 100 lesions were resected using ESMR‐L, and 55 lesions were resected using EMR. Histopathologically, all tumors were free from lymphovascular and perineural invasion. The overall ESMR‐L complete resection rate was higher than that of EMR (93.3% vs 65.5%, respectively, P = 0.001). Furthermore, the location of the tumors had no influence on the complete resection rate when ESMR‐L was carried out, in contrast to the results of EMR. The procedure‐related variables of procedure time and complication rate were not significantly different between the two groups.Conclusion  ESMR‐L is a significantly superior modality to EMR for the complete removal of small rectal carcinoid tumors that are 10 mm or less in diameter.
The Forgotten Cultures of the Qur'an
Authors: Grandguillaume Gilbert 
Published: July 2011

AbstractThis paper brings to the attention of the reader some examples of how the words of the Qur’an, when examined in their literal sense, appear to connect with languages or cultures other than those acknowledged by traditional muslim apologetics. as such, they may be echoing origins that these apologetics have dismissed from their discourse. In fact, whereas traditional exegesis has generally tended to limit the Qur’an exclusively to the arabic language as sufficient guarantee by itself of its authenticity, the words of the text reveal a linguistic and cultural multiplicity which demonstrates the richness of its roots. In pursuing this repression exerted on outside contextual influences, the author focuses on three avenues: the pre-Islamic culture of the nomadic arabs, the Judeo-Christian culture and the hellenic culture. Those languages which go wilfully unrecognized, those practices whose recollection is passed over, prove to be of great assistance to understanding the sense of certain verses of the Qur’an.
Mists and Turbulence in the ‘Sunni’ Ocean
Authors: Seddik Youssef 
Published: July 2011

AbstractThis paper focuses on the concept of sunna, and its great theoretical and historical complexity. The term “sunna” seems nowadays to be a label for the whole set of behaviors adopted by believers, from simple details of dress or diet to the most elaborate of ritual and cultural attitudes. The daily lifestyle of the prophet is invoked so as to imitate the way he washed, how he lay down to sleep, or “sat at table”, not to mention his ritual gestures during prayer, what he preferred to eat after breaking fasts, his slightest movements over the nights and days of pilgrimage. The author intends to show on the contrary, through an unprecedented study, that the Islamic society of a very large city, that of 10th century Baghdad, was for a considerable period of time completely disengaged from such obsessive scrupulousness of religious observance. It gives large evidence of this phenomenon, and tries to outline the historical reasons how the sunna eventually evolved into a rule defining the coercive power of the Islamic faith.
Banasa préromaine. Un état de la question
Authors: Girard Sylvie 
Published: July 2011

La confrontation entre les coupes stratigraphiques établies en 1955-1956 et les quelques sondages antérieurs dispersés permet d'éclaircir la question controversée de l'origine des deux collines, autour desquelles devait s'édifier la Colonia Iulia Valentia Banasa, et de préciser les rapports entre l'habitat et son cadre géomorphologique. Le processus de son développement paraît très nettement lié au phénomène d'alluvionnement périodique qui souligne et amplifie, dans la stratigraphie, les différentes phases de l'occupation du site, du IVe siècle avant J.-C. au IIIe siècle après.
La continuité de l'occupation est attestée par la permanence d'une industrie de potiers sur toute la surface de l'agglomération et durant toute sa vie préromaine.
Le catalogue, puis l'état de cette céramique locale, partie largement prédominante du mobilier recensé, constitue le deuxième volet de cette analyse. L'étude quantitative des tessons peints recueillis dans chaque niveau complète les séquences stratigraphiques. Un essai de classement des types de décors peints, assorti d'un travail similaire sur les formes, conduit à mettre en relief l'originalité de cette production indigène imprégnée, sans y être soumise, d'influences extérieures, grecques ou phénico-ibérique, véhiculées par le commerce méditerranéen.
La chronologie, cernée de plus près par ces observations, se précise dans le sens d'une datation basse, les témoins d'une datation haute étant rares, et, pour la plupart, peu fiables.
Un nouveau témoignage du culte de Tanit-Caelestis à Cherchel ?
Authors: Benseddik N. doublon 
Published: July 2011

Ex-voto laid on 1978 down Cherchel Museum. The upper register shows a date-palm tree with two big ears ; the lower register is taken up with the dedication made by Oneratus, Lucia and their children, and which can be assigned to the second century.
The raised divinity is not represented. May its identity be deduced from symbols of punie tradition : the date-palm tree symbol of fruitfulness and fecundity ; the ears showing the divinity listening to the faithful ? Is it Tanit Caelestis or an anonymus deity embodied in the date-palm tree : the Fecundity ?