bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of major adverse cardiac events during 7-days period in acute coronary syndrome patients who had percutaneous coronary intervention in Cipto Mangunkusumo National Hospital, Jakarta
Authors: Djallalludin  , Wijaya Ika Prasetya , Koesnoe Sukamto , Alwi Idrus 
Published: May 2024

Link of Video Abstract: https://youtu.be/YDWnVBBGC0Q

Background: Major adverse cardiac events (MACE) increase the morbidity and mortality of patients with acute coronary syndrome (ACS). Data are lacking on MACE occurrence in patients with ACS after percutaneous coronary intervention (PCI). This study aims to find out the predictors of MACE during 7 days in ACS patients who had PCI.
Methods: The study design was unmatched case-control. The study included 461 patients with ACS who were hospitalized in the intensive cardiology care unit in Cipto Mangunkusumo Hospital from January 1st, 2015 until November 30th, 2017. Age, female sex, diabetes mellitus, hypertension, heart failure, kidney function disorder, cardiogenic shock, ejection fraction ≤ 40%, left main (LM) coronary artery stenosis, arrhythmia, 3-vessel coronary artery stenosis, and left anterior descending (LAD) artery stenosis were included in the analysis as predictors of MACE.
Results: Cardiogenic shock (OR = 10.65, p = 0.001), LAD stenosis (OR = 15.23, p = 0.02), ejection fraction ≤ 40% (OR = 10.8, p = 0.00), 3-vessels or more coronary artery stenosis (OR 3.47, p = 0.01), heart failure (OR = 3.1, p = 0.02), and renal function disorder (OR 4.76, p = 0.00) were proven as predictors of MACE during 7-days period in ACS patients who had PCI. Female sex, cardiogenic shock, LAD stenosis, and ejection fraction ≤ 40% were independent predictors of MACE in ACS patients who had PCI, with OR values of 6.33 (95%CI 1.32- 30.50), OR 17.56 (1.85-167.06), OR 26.61 (1.38-513.81), and OR 7.6 (1.86-31.09), respectively.
Conclusion: Cardiogenic shock, LAD stenosis, ejection fraction ≤ 40%, ≥ 3 vessels stenosis, heart failure, and renal function disorder were predictors of MACE during 7 days in ACS patients who had PCI.
Association between Human Papilloma Virus (HPV) genotype and protein of retinoblastoma expression in cervical cancer
Authors: Rauf Nadia Kurnia Wardani , Arifuddin Sharvianty , Jusuf Elizabet Catherine , Cangara Muhammad Husni , Hamid Firdaus , Pelupessy Nugraha Utama , Bahar Irnawaty 
Published: May 2024

Link of Video Abstract: https://youtu.be/5Q9QmV4Qmyg

Background: Regarding prevalence among females worldwide, cervical cancer ranks fourth and has a high fatality rate. Cervical cancer growth is correlated with high-risk human papillomavirus (HPV) infection. Retinoblastoma protein (pRb) is a protein that interacts with E6/E7 oncoproteins to regulate cell proliferation, differentiation, and death. Mutations on the E6/E7 protein oncogenes of high-risk HPV can disrupt this relationship. This investigation aims to establish the association between pRb expression and the HPV genotype.
Methods: This observational cross-sectional study examined 43 patients diagnosed with cervical cancer at Wahidin Sudirohusodo Hospital and its network. Samples were taken using consecutive random sampling based on established criteria. HPV genotype was examined using the polymerase chain reaction (PCR) method, while pRB expression was assessed by immunohistochemical examination. The relationship between the two variables was assessed using the Chi-Square test.
Results: There were 5 (11.6%) patients with HPV type 16, 14 (32.6%) with HPV type 18, 12 (27.9%) with other types of HPV and 12 (27.9%) were negative for HPV. Examination of pRb expression showed that 33 (76.7%) samples had +2 expression, 7 (16.3%) had +1 expression, and 3 (7.0%) samples had no pRb expression. The pRb expression and HPV type were not significantly correlated in this study (p = 0.410). However, pRb expression and cervical cancer clinical stage were shown to be significantly correlated (p = 0.007).
Conclusion: pRb expression is more prevalent when a malignancy is more advanced. In this investigation, no association between HPV genotype and pRb expression was discovered, despite oncogene mutations being involved in the regulation mechanism of cell proliferation, differentiation, and apoptosis.
Hyperglycemia may induce a decrease in myoblast viability: A Preliminary Study
Authors: Rizal Dicky Moch , Setiawan Jajar , Susanti Susi , Adzillina Laksmita Dewi , Septiyorini Nandia 
Published: May 2024

Link of Video Abstract: https://youtu.be/6j-cheXQzQE

Background: Hyperglycemia plays a significant role in developing insulin resistance, leading to a continuous decline in metabolism. Uncontrolled long-term hyperglycemia has deleterious effects on muscles, leading to a decline in muscle mass, impaired capillarization, and muscle atrophy. We identified the effect of hyperglycemia on reducing myoblast cell viability through observation using the MTT assay.
Methods: Primary culture of myoblast cells was performed using rat's muscle tissue which was further induced by hyperglycemia by adding D-glucose with concentrations of 10 mM, 25 mM, and 50 mM in the plating media. Cell viability was observed using the MTT assay by identifying the absorbance using an ELISA reader with λ=550-600 nm (595 nm)
Results: There was a significant decrease in cell viability (p=0.000) due to administering various glucose concentrations in the plating media. There is a negative correlation between glucose concentration and myoblast cell viability (P-value = 0.000; t = -8.284; r = -0.926)
Conclusion: Elevated blood sugar levels result in a significant reduction in the viability of myoblast cells, as indicated by the MTT assay. The MTT assay proved invaluable for precisely evaluating myoblast cell viability in the context of hyperglycemia.
Intracerebral hemorrhage and ischaemic stroke due to Moyamoya disease in young patients: a case report
Authors: Wicaksono Ricky Dany Agus , Sani Achmad Firdaus , Kurniawan Dedy 
Published: May 2024

Link of Video Abstract: https://youtu.be/DWVi34rPNOg

Background: Moyamoya disease (MMD) is a non-atherosclerotic cerebrovascular disorder characterized by progressive stenosis of the distal part of the internal carotid artery (ICA), thus forming an abnormal vascular network in the base of the brain. MMD is often found in women. The common symptoms of MMD are migraine, epilepsy, recurrent transient ischemic attack (TIA), ischemic stroke, and intracerebral hemorrhage. Stroke at young onset has challenges in looking for risk factors and etiology. A detailed examination is needed to prevent recurrent strokes.
Case Presentation: Male 17-year-old complained of a throbbing headache on the right side for 5 months, with a numeric rating scale (NRS) 4. The headache duration was 24-72 hours, with a frequency of 1-2 times a month. Complaints are exacerbated by activity and improve when taking over medication. 2 months after the first onset, he felt severe headache with NRS 7, accompanied by weakness and tingling on the left side. All his laboratory results were within normal limits. Cerebral Digital Subtraction Angiography (DSA) results showed severe stenosis at the base of the right ICA bifurcation segment accompanied by slow flow at the right middle cerebral artery (MCA) and severe stenosis at the base of the left ICA accompanied by cross-filling to the contralateral anterior cerebral artery (ACA). Cortico-cortical collaterals were obtained from the posterior cerebral artery (PCA) branch covering the MCA area. The patient was diagnosed with MMD.
Conclusion: MMD is a rare cerebrovascular disease that can be a risk factor for stroke at a young age. Diagnosis and evaluation of the collateral system need to be carried out through cerebral angiography so that the selection and consideration of appropriate management of recurrent stroke attacks can be carried out.
The effect of blood flow restriction in low-intensity load exercise on isokinetic strength of the quadriceps muscles in knee osteoarthritis
Authors: Dugis Priscilla Anastasia Fitriany , Tinduh Damayanti , Pawana I Putu Alit , Utomo Dwikora Novembri , Melaniani Soenarnatalina 
Published: May 2024

Link of Video Abstract: https://youtu.be/tduoO-xy3ZE

Introduction: Cartilage destruction in knee osteoarthritis (KOA) caused the inflammation process. It makes the patient complain of knee pain, tends to immobilize, and induced neural inhibition (Arthrogenic muscle inhibition) on the quadriceps muscle as a knee stabilator and shock absorbent. These caused quadriceps weakness. The combination of blood flow restriction (BFR) and low-intensity resistance training (LIRT) showed an improvement in isotonic peak torque significantly, but the prescription is varied and limited in Indonesia.
Patient and Methods: This was a clinical experimental study with randomized control trial with pre and post-test design. The subjects were 28 KOA patients (50-70 years old). The intervention group (n=14) received a combination of low-load resistance training (30% 1-RM; 75 repetitions) and BFR (50 mmHg). The control group (n=14) received low load resistance training only (30% 1-RM; 75 repetitions). Both groups received training 2 times per week with a Q-bench machine for 6 weeks. Isokinetic peak torque was assessed before and after the training program.
Results: There was a significant improvement in isokinetic peak torque before and after the training program in both groups (intervention group p=0.001; control group p=0.000). There was a significant improvement of delta isokinetic peak torque between both groups (p=0.018) and post-test between both groups (p=0.044). The effect size value of the intervention group was 1.22 (very large) and the control group was 0.89 (large).
Conclusions: The addition of BFR on LIRT for 6 weeks can improve isokinetic quadriceps strength in patients with knee osteoarthritis
The α-smooth muscle actin (α-SMA) and collagen type III expression of Platelet Rich Fibrin (PRF) membrane in conjunctival wound healing: a literature review
Authors: Wiratama Agung Bhakti , Prastyani Reni , Wahyuni Indri , Valentinus Thomas , Notobroto Hari Basuki 
Published: May 2024

Link of Video Abstract: https://youtu.be/bL0NSpeda_k

The platelet-rich fibrin (PRF) membrane represents a new reconstructive material employed in ocular surface procedures. Platelet-rich fibrin (PRF) offers several notable benefits, including its potential to mitigate inflammation, its abundance of growth factors, and its capacity to serve as a transient framework for fibroblast migration. Nevertheless, despite the numerous benefits it offers, PRF is not extensively utilized in comparison to alternative methods like conjunctival autograft. The utilization of conjunctival autograft has been a longstanding approach in ocular surface reconstruction methodologies; however, it is not without its inherent limitations. Therefore, the utilization of the PRF membrane technique presents a viable solution for addressing this particular scenario. This literature review aims to present a comprehensive analysis of the role of PRF in the regulation of inflammation and its potential to facilitate the healing of conjunctival wounds. This review is expected to stimulate further experimental investigations into the influence of α-SMA and collagen type III expression on the efficacy of PRF membranes in promoting conjunctival wound healing.
Soursop leaves (Annona muricata Linn) ethanol extract prevents cisplatin-induced kidney injury of mice (Mus musculus) through SOD and MDA analysis
Authors: I Made Sudanta  , Djoko Santoso  , Sudiana I Ketut , Siswandono  
Published: May 2024

Background: Cancer treatment has been carried out in various ways, including surgery, chemotherapy and immunotherapy. Cisplatin is often used for chemotherapy, but the use of cisplatin still has extensive side effects, including kidney injury. The ethanol extract of soursop leaves contains antioxidants expected to reduce ROS or induce SOD, glutathione and catalase, thereby preventing kidney injury. This study aims to explain the effect of soursop leaves ethanol extract on preventing kidney injury caused by cisplatin administration in animal models.
Method: This study is a true experimental study with a randomized, posttest-only control group design. We used 40 mice and randomly divided them into 5 groups, each group containing 8 mice. The K0 group was given aquadest, the K1 group was given cisplatin 20 mg/kgBW, the KP1 group was given cisplatin and soursop leave ethanol extract 100 mg/kgBW, the KP2 group was given cisplatin and soursop leave ethanol extract 200 mg/kgBW, the KP3 group given cisplatin and soursop leaves ethanol extract 400mg/kgBW. The extract was given orally for 5 days in a row. MDA and F2-isoprostane were measured using Immunohistochemistry. The data were all analyzed using an ANOVA test.
Results: Soursop leaves ethanol extract with 200 mg/kgBW is the most effective dose to prevent kidney injury from cisplatin exposure. Soursop leaves ethanol extract can increase the expression of SOD and decrease the MDA metabolites.
Conclusion: Soursop leaves ethanol extract can prevent kidney injury by increasing SOD and decreasing MDA.
Comparison of cognitive function tests AD8-INA against MoCA-INA and CDT in the elderly age group at the Uabau Health Center
Authors: Ariani Ni Putu Inna , Pramaswari Anak Agung Ayu Agung 
Published: May 2024

Background: Dementia is a syndrome of decreased cognitive ability that hinders daily life. Dementia is associated with mortality, especially in patients with major depression, so health services are needed to identify cognitive disorders through pre-elderly and elderly screening. AD8-INA is one of the cognitive screening methods where the questions are directed to patient caregivers that are most practical, concise, and suitable for patients who cannot use their dominant hand, so researchers are interested in studying the sensitivity and specificity of AD8-INA to MoCA-INA and CDT.
Methods: A cross-sectional study design was used to observe and analyze cognitive function variables. This study used primary data sources with interviews based on questionnaires on 114 subjects, consisting of pre-elderly and elderly groups who met the eligibility criteria to be included in the study. The MoCA-INA scores were divided into 26 normal and 26 cognitive impairments, the CDT scores 4 normal and 4 cognitive impairments, and the AD8-INA scores 0–1 normal and 2 cognitive impairments. An analysis was carried out to determine the sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, negative likelihood ratio, and confidence interval.
Results: It was found that the sensitivity of AD8-INA to MoCA-INA was 87.14%, AD8-INA to CDT was 82.14%. In addition, the specificity of AD8-INA to MoCA-INA was 50% and AD8-INA to CDT was 61.11%.
Conclusion: AD8-INA has high sensitivity but low specificity. AD8-INA can still be used as an initial screening tool for cognitive function at the Uabau Health Center, but all examination results must be evaluated further.
Aesthetic outcome comparison between Millard and Fisher technique for cleft lip surgery: a literature review
Authors: Pradnyandari Ni Kadek Parswa Diah 
Published: May 2024

Background: Cleft lip is the most common congenital defect found in children, with a prevalence of 0.5 to 1.6 per 1000 live births. Besides causing functional problems, a cleft lip greatly affects the patient's aesthetic appearance. Therefore, several surgical techniques have been developed to produce a good clinical appearance to support the patient's social functioning. The Millard and Fisher technique is the most widely used cleft lip surgery (cheiloplasty) technique. This literature review aims to compare the aesthetic outcomes between the Millard and Fisher techniques in cleft lip surgery.
Methods: This literature review was carried out by searching studies in online databases in the form of PubMed, the Cochrane Library, and Google Scholar using the keywords "cleft lip surgery," "Millard," "Fisher," "aesthetic outcome," and "comparison." Appropriate studies were then carried out through a narrative synthesis analysis.
Discussion: The Millard technique uses the principle of rotational and advancement flaps, performed by making incisions and flaps on two sides, namely a rotational flap on the medial lip and an advancement flap on the lateral lip. Meanwhile, the Fisher technique uses the principle of anatomical subunit approximation, in which the measurement of the boundaries and extent of the surgical procedure is very accurate, resulting in a more anatomical position of the scar tissue. Regarding surgical scars, nose symmetry, vermillion, Cupid's bow and nasal, and Steffensen grading, better aesthetic results were found in Fisher's technique compared to Millard's.
Conclusion: Fisher's technique provides superior aesthetic results compared to Millard's technique in cleft lip surgery.
Correlation between level of vitamin d and svcam-1 towards degree of hypertension in elderly patients
Authors: RA Tuty Kuswardhani  , Luh Oliva Saraswati Suastika  , Nicholas Wijayanto  
Published: May 2024

Introduction: At old age, it is often found the condition of vitamin D deficiency associated with decrease of physical performance, increase risk of fall and as the risk of hypertension. sVCAM-1 is a protein expressed on endothelium surface which being activated and also expressed in the initial event of atherosclerosis so that sVCAM-1 can be used as marker to determine the degree of severity of atherosclerosis in human. This study was aimed to evaluate the correlation between vitamin D and sVCAM-1 towards degree of hypertension in elderly patients.
Methods: This research was using cross-sectional method conducted at Geriatric Outpatient Clinic, Kidney-Hypertension and Cardiology in Prof. Dr. Ngoerah General Hospital, Denpasar, Bali, Indonesia, starting from April 2022 up to August 2022. Study sample was all of elderly population who came to clinic. Sample was taken using the means of consecutive sampling. Chi-square test was used for bivariate analysis and regression logistical multiple regression test was used for multivariate analysis.
Results: Result of bivariate analysis showed that sVCAM-1 was significantly related to the degree of hypertension, in which it obtained the value of p = 0.030, with OR = 3.3. The result was also directly proportional with relation to level of vitamin D towards degree of hypertension, in which it obtained the value of p = 0.031, with OR value = 8.0. In multivariate analysis it obtained that the level of sVCAM-1 was significant statistically towards the degree of hypertension, with p value of 0.032.
Conclusion: Based on this study, the results can become reference, in which low level of vitamin D and high level of sVCAM-1, associated with higher blood pressure in elderly patients.
The use of sitting grinder reduces musculoskeletal complaints disorders, workload, and increases work productivity of blacksmith in Tabanan, Bali, Indonesia
Authors: Arjani Ida Ayu Made Sri , Hana Sundari Cokorda Dewi Widhya , Mastra Nyoman , Mahayana I Made Bulda , Swastini I Gusti Agung Ayu Putu 
Published: May 2024

Introduction: Blacksmithing is one of the small industries in Tabanan Regency. Their work is passed down from generation to generation as a responsibility of their ancestors. One of the processes in making household appliances is to use a grinder to smooth and sharpen knives. In this process, the worker holds the vibrating grinder, which weighs more than 1.5 kg, with one hand, and the other hand holds the knife to be smoothed. Working with hands exposed to vibration for a long period of time is a burden that will cause complaints and diseases for workers such as raynaud's syndrome, tenosynovitis, and carpal tunnel syndrome. The purpose of this study was to determine the effect of the use of ergonomic sitting grinders to reduce musculoskeletal disorders (MSDs), workload, and increase work productivity of blacksmith in Tabanan Regency.
Methods: This study is an experimental model. The population was blacksmith workers in Tabanan Regency. Samples were determined based on small industry groups by simple random sampling. The sample size was determined based on the score of musculoskeletal complaints so that the number of small industry groups was obtained as many as 3 groups. Each group consisted of 11 people so the sample size was 33 people. It was determined that the sample size in this study was 33 workers in 3 small industry groups.
Result: this study obtained decreased musculoskeletal complaints by 51.51% in the control group with treatment I, and by 51.75% in the control group with treatment II. There was a decrease in workload by 13.71% in the control group with treatment I and by 15.60% in the control group with treatment II. There was an increase in work productivity by 20.93% in the control group with treatment I and by 24.44% in the control group with treatment II.
Conclusion: There is a significant decrease in musculoskeletal complaints and workload between the Control group with treatment I and the control group with Treatment II (p<0.05), and there is a significant increase in work productivity in the control group with treatment I and in the control group with treatment II.
Tatalaksana seorang pasien dengan kecurigaan alergi makanan mengandung iodine dan memiliki riwayat reaksi hipersensitivitas zat kontras yang menjalani pemeriksaan dengan media kontras berbasis iodine: sebuah laporan kasus
Authors: Deviani Ida Ayu Putu Padmi , Suardamana I Ketut 
Published: May 2024

Background: Radiocontrast agents are some of the most used medications in the emergency department. However, physicians and patients misunderstand the role of allergies in reactions to radiocontrast media, especially regarding shellfish and iodine. A history of prior reaction to contrast increases the risk of mild reactions to as high as 7-17% but has not been shown to increase the rate of severe reactions.
Case Illustration: A 43-year-old female patient was admitted to the hospital with planned coronary angiography. The patient with a history of suspected contrast hypersensitivity 2 months ago when the patient did cardiac CT angiography. The patient also stated that she has an allergy to eggs, shrimp, shells, nuts, and mackerel tuna. The patient was given premedication with oral 50 mg prednisone at 13 hours and 7 hours before the procedure, and oral 50 mg prednisone plus 50 mg intramuscular diphenhydramine 1 hour before the procedure. Hypersensitivity reaction during admission did not occur.
Conclusion: The management and prophylaxis of contrast allergy include analyzing the history of contrast allergy before and premedication with steroids and antihistamines.

Latar Belakang: Agen radiokontras adalah salah satu obat yang paling banyak digunakan di unit gawat darurat. Namun, seringkali dokter dan pasien salah memahami peran alergi terhadap reaksi terhadap media radiokontras, terutama mengenai kerang dan yodium. Riwayat reaksi sebelumnya terhadap kontras meningkatkan risiko reaksi ringan hingga 7-17% namun belum terbukti meningkatkan reaksi berat.
Ilustrasi Kasus: Seorang pasien wanita berusia 43 tahun dirawat di rumah sakit dengan rencana angiografi koroner. Pasien dengan riwayat dugaan hipersensitivitas kontras 2 bulan yang lalu saat pasien dilakukan CT angiografi jantung. Pasien juga menyatakan bahwa dirinya memiliki alergi terhadap telur, udang, kerang, kacang-kacangan, dan ikan tongkol. Pasien diberikan premedikasi dengan prednison 50 mg oral pada 13 jam dan 7 jam sebelum prosedur, dan prednison 50 mg oral ditambah 50 mg difenhidramin intramuskular 1 jam sebelum prosedur. Reaksi hipersensitivitas saat di rumah sakit tidak terjadi.
Kesimpulan: Penatalaksanaan dan profilaksis alergi kontras meliputi analisis riwayat alergi kontras sebelumnya serta premedikasi dengan steroid dan antihistamin.