bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS SENTIMEN BAHASA PADA ULASAN DALAM MEMPENGARUHI CITRA MERK PRODUK
Authors: Hamizar Arizal 
Published: June 2024

AbstractThis study aims to analyze the sentiment of consumer reviews language towards the formation of brand image of a product in the context of online purchasing. This research focuses on how the language used in consumer reviews can influence perceptions of a product's brand image. A qualitative method is employed to gain in-depth insights into how consumers respond to existing product reviews. The sample consists of consumers who actively read other consumers' reviews before making a purchase. The results of the research show that sentiment language plays a role in shaping consumers' perceptions of a product's brand image. Positive sentiments in reviews tend to reinforce a positive brand image, while negative sentiments tend to damage it. The interpretation of sentiments is influenced by how much they align with consumers' preferences and their intensity. Strong sentiments have a more significant impact on brand image formation. Contextual factors and product characteristics also play a role in the influence of sentiment language on brand image. Products that are important to consumers have a greater impact of sentiment on brand perception.Keywords: Sentiment Language, brand image, reviews AbstrakPenelitian ini bertujuan untuk menganalisis sentimen bahasa ulasan konsumen terhadap pembentukan citra merek produk dalam konteks pembelian online. Penelitian ini difokuskan pada bagaimana bahasa yang digunakan dalam ulasan konsumen dapat mempengaruhi persepsi terhadap citra merek suatu produk. Metode kualitatif digunakan untuk mendapatkan wawasan yang mendalam tentang bagaimana konsumen merespons ulasan produk yang ada. Sampel terdiri dari konsumen yang secara aktif membaca ulasan konsumen lain sebelum melakukan pembelian produk. Hasil penelitian menunjukkan bahasa sentimen memiliki peran dalam membentuk persepsi konsumen terhadap citra merek produk. Sentimen positif dalam ulasan cenderung memperkuat citra merekpositif, sementara sentimen negatif cenderung merusak citra merek. Interpretasi sentimen dipengaruhi oleh sejauh mana sentimen tersebut sejalan dengan preferensi konsumen dan intensitasnya. Sentimen yang sangat kuat memiliki dampak yang lebih signifikan pada pembentukan citra merek. Faktor kontekstual dan karakteristik produk juga memainkan peran dalam pengaruh bahasa sentimen pada citra merek. Produk yang penting bagi konsumen memiliki dampak sentimen yang lebih besar pada persepsi merek.Kata Kunci: Bahasa Sentimen, Citra Merek, Ulasan
Study on the optimum value of remanent magnetism for suppressing ferromagnetic resonance of voltage transformer in all-cable line
Authors: Yonghao Huang , Shuheng Dan , Zhiyuan Liu 
Published: June 2024

Introduction: Due to the need for safety and aesthetics, 10 kV urban power grids are gradually dominated by all-cable lines. However, this trend also brings new challenges. Cables, which are equivalent to capacitors at industrial frequency, are prone to resonate with the voltage transformers (PTs) in the system, causing drastic changes in current and voltage and posing a threat to the stable operation of the system. In addition, the intrusion of lightning waves into the substation will lead to different residual magnetization in the PT core, which further changes the core inductance value and affects the ferromagnetic resonance of the system to a certain extent.Methods: In order to deeply investigate the influence of remanent magnetism on the ferromagnetic resonance of the system, this paper establishes a simulation model of a 10 kV all-cable line based on the PSCAD software, and adopts a UMEC transformer capable of simulating the saturation characteristics to construct the PT, and simulates the intrusion currents by using a DC current source in order to generate remanent magnetism. By this method, the effect of remanent magnetization on the ferromagnetic resonance of the system is explored at different magnitudes and directions.Results: The results of the study show that the residual magnetization has a significant effect on the ferromagnetic resonant inrush current of the voltage transformer. When the remanent magnetization value is positive and less than 0.6 pu, the ferromagnetic resonance inrush current of PT can be effectively suppressed, and the smaller the remanent magnetization value is, the better the suppression effect is. However, negative remanent magnetization cannot suppress the ferromagnetic resonance of the PT, but may exacerbate the inrush current, leading to more serious consequences.Conclusion: This study helps to improve the stability of the power grid and also provides a valuable reference for future grid design and maintenance.
Burn pit exposure in military personnel and the potential resulting lung and neurological pathologies
Authors: Penuelas Veronica L. , Lo David D. 
Published: June 2024

IntroductionMilitary personnel and local civilians at various deployment locations are plagued with serious health conditions. Evidence points to burn pit emissions as the cause of these pathologies; however, similar diseases are also caused by environmental exposures, smoking, genetic predispositions, or other comorbidities. Burn pits, which are large smoldering piles of refuse ignited with jet or diesel fuel, contain human and medical waste as well as paint, plastics, ammunition, and other materials—each of which can be attributed to health concerns in other industrial settings. Here we compare various pathologies attributable to toxic aerosol exposures and discuss distinct pathologies that may be linked to burn pit exposures.ObjectivesWe performed a literature review where we provide information on toxic exposures that may pose relevance to burn pit exposure and furthermore, highlight what is already known about burn pit exposures and what steps need to be taken to diagnose and correlate certain respiratory pathologies to chronic exposure from overseas burn pits.Data sourcesWe conducted searches through PubMed and Google Scholar to determine where gaps in our knowledge of burn pit exposure lie. Thorough review on jet-fuel properties and particulate matter were performed as supporting evidence of potential toxins from burn pit emissions.ResultsTo date, studies on burn pit emissions consist mainly of systematic reviews and discussions to address the problem, with very few acute-exposure studies and little to no chronic-exposure studies. We found that symptoms range from respiratory pathologies to neurological deficits, but treatment has been limited as medical facilities, such as the Veterans Administration (VA), require proof that a condition is service-connected.ConclusionsTo determine the effects of burn pit exposure on humans, chronic exposure to mimicked burn pit emissions is necessary to draw definitive conclusions between phenotypic differences in pathologies linked to exposure. By determining phenotypic differences, conclusions can be made about the pathologic origins, potentially leading to future diagnoses and treatments for veterans and affected civilians.
IgG4-related disease with nasopharyngeal malignancy-like manifestations
Authors: Lin Xijun , Lin Peiliang , Fan Jianming , Zhang Biying , Liang Faya , Han Ping , Liu Xiang , Huang Xiaoming 
Published: June 2024

BackgroundIgG4-related disease (IgG4-RD) was characterized by single or multiple masses in organs, which may mimic various inflammatory and malignant diseases. Here, we summarize 4 patients with aggressive manifestations of IgG4-RD that mimic nasopharynx cancer to provide some new sights for the diagnosis of IgG4-RD.Case summaryFour patients were included in our series. The age ranged from 53 to 64 years old, and the duration of the disease ranged from 4 to 6 months. The chief complaints included headache, rhinorrhea, or diplopia. All patients had more than 10 IgG4+ plasma cells/HPF in immunohistochemistry with plasma lgG4 levels ranging from 218 mg/dL to 765 mg/dL. All of them met the diagnostic criteria of lgG4-RD.ConclusionThe described case is highly similar to the clinical manifestations of nasopharyngeal carcinoma. Although pathology is the gold standard, there are still limitations. Serological IgG4 can help confirm the diagnosis. Timely diagnosis of IgG4-RD is of great significance in preventing secondary organ damage in patients with active diseases.
Fermented Aronia melanocarpa pomace improves the nutritive value of eggs, enhances ovarian function, and reshapes microbiota abundance in aged laying hens
Authors: Li Zhihua , Qin Binghua , Chen Ting , Kong Xiangfeng , Zhu Qian , Azad Md. Abul Kalam , Cui Yadong , Lan Wei , He Qinghua 
Published: June 2024

IntroductionThere is a decline in the quality and nutritive value of eggs in aged laying hens. Fruit pomaces with high nutritional and functional values have gained interest in poultry production to improve the performance.MethodsThe performance, egg nutritive value, lipid metabolism, ovarian health, and cecal microbiota abundance were evaluated in aged laying hens (320 laying hens, 345-day-old) fed on a basal diet (control), and a basal diet inclusion of 0.25%, 0.5%, or 1.0% fermented Aronia melanocarpa pomace (FAMP) for eight weeks.ResultsThe results show that 0.5% FAMP reduced the saturated fatty acids (such as C16:0) and improved the healthy lipid indices in egg yolks by decreasing the atherogenicity index, thrombogenic index, and hypocholesterolemia/hypercholesterolemia ratio and increasing health promotion index and desirable fatty acids (P &lt; 0.05). Additionally, FAMP supplementation (0.25%−1.0%) increased (P &lt; 0.05) the ovarian follicle-stimulating hormone, luteinizing hormone, and estrogen 2 levels, while 1.0% FAMP upregulated the HSD3B1 expression. The expression of VTG II and ApoVLDL II in the 0.25% and 0.5% FAMP groups, APOB in the 0.5% FAMP group, and ESR2 in the 1% FAMP group were upregulated (P &lt; 0.05) in the liver. The ovarian total antioxidant capacity was increased (P &lt; 0.05) by supplementation with 0.25%−1.0% FAMP. Dietary 0.5% and 1.0% FAMP downregulated (P &lt; 0.05) the Keap1 expression, while 1.0% FAMP upregulated (P &lt; 0.05) the Nrf2 expression in the ovary. Furthermore, 1.0% FAMP increased cecal acetate, butyrate, and valerate concentrations and Firmicutes while decreasing Proteobacteria (P &lt; 0.05).ConclusionOverall, FAMP improved the nutritive value of eggs in aged laying hens by improving the liver–blood–ovary function and cecal microbial and metabolite composition, which might help to enhance economic benefits.
NoC simulation steered by NEST: McAERsim and a Noxim patch
Authors: Robens Markus , Kleijnen Robert , Schiek Michael , van Waasen Stefan 
Published: June 2024

IntroductionGreat knowledge was gained about the computational substrate of the brain, but the way in which components and entities interact to perform information processing still remains a secret. Complex and large-scale network models have been developed to unveil processes at the ensemble level taking place over a large range of timescales. They challenge any kind of simulation platform, so that efficient implementations need to be developed that gain from focusing on a set of relevant models. With increasing network sizes imposed by these models, low latency inter-node communication becomes a critical aspect. This situation is even accentuated, if slow processes like learning should be covered, that require faster than real-time simulation.MethodsTherefore, this article presents two simulation frameworks, in which network-on-chip simulators are interfaced with the neuroscientific development environment NEST. This combination yields network traffic that is directly defined by the relevant neural network models and used to steer the network-on-chip simulations. As one of the outcomes, instructive statistics on network latencies are obtained. Since time stamps of different granularity are used by the simulators, a conversion is required that can be exploited to emulate an intended acceleration factor.ResultsBy application of the frameworks to scaled versions of the cortical microcircuit model—selected because of its unique properties as well as challenging demands—performance curves, latency, and traffic distributions could be determined.DiscussionThe distinct characteristic of the second framework is its tree-based source-address driven multicast support, which, in connection with the torus topology, always led to the best results. Although currently biased by some inherent assumptions of the network-on-chip simulators, the results suit well to those of previous work dealing with node internals and suggesting accelerated simulations to be in reach.
Renshen Yangrong decoction for secondary malaise and fatigue: network pharmacology and Mendelian randomization study
Authors: Wang Fanghan , Zhu Liping , Cui Haiyan , Guo Shanchun , Wu Jingliang , Li Aixiang , Wang Zhiqiang 
Published: June 2024

BackgroundRenshen Yangrong decoction (RSYRD) has been shown therapeutic effects on secondary malaise and fatigue (SMF). However, to date, its bioactive ingredients and potential targets remain unclear.PurposeThe purpose of this study is to assess the potential ingredients and targets of RSYRD on SMF through a comprehensive strategy integrating network pharmacology, Mendelian randomization as well as molecular docking verification.MethodsSearch for potential active ingredients and corresponding protein targets of RSYRD on TCMSP and BATMAN-TCM for network pharmacology analysis. Mendelian randomization (MR) was performed to find therapeutic targets for SMF. The eQTLGen Consortium (sample sizes: 31,684) provided data on cis-expression quantitative trait loci (cis-eQTL, exposure). The summary data on SMF (outcome) from genome-wide association studies (GWAS) were gathered from the MRC-IEU Consortium (sample sizes: 463,010). We built a target interaction network between the probable active ingredient targets of RSYRD and the therapeutic targets of SMF. We next used drug prediction and molecular docking to confirm the therapeutic value of the therapeutic targets.ResultsIn RSYRD, network pharmacology investigations revealed 193 possible active compounds and 234 associated protein targets. The genetically predicted amounts of 176 proteins were related to SMF risk in the MR analysis. Thirty-seven overlapping targets for RSYRD in treating SMF, among which six (NOS3, GAA, IMPA1, P4HTM, RB1, and SLC16A1) were prioritized with the most convincing evidence. Finally, the 14 active ingredients of RSYRD were identified as potential drug molecules. The strong affinity between active components and putative protein targets was established by molecular docking.ConclusionThis study revealed several active components and possible RSYRD protein targets for the therapy of SMF and provided novel insights into the feasibility of using Mendelian randomization for causal inference between Chinese medical formula and disease.
A pharmacovigilance study of chronic kidney disease in diabetes mellitus patients with statin treatment by using the US Food and Drug Administration adverse event reporting system
Authors: Zhang Jingyi , Guo Yuting , Wei Chunyan , Yan Yu , Shan Huifang , Wu Bin , Wu Fengbo 
Published: June 2024

BackgroundStatins were regarded as a main medication for managing hypercholesterolemia. Administration of statin therapy could reduce the incidence of cardiovascular disease in individuals diagnosed with type 2 diabetes mellitus (DM), which was recognized by multipal clinical guidelines. But previous studies had conflicting results on whether the long-term use of statins could benefit the renal function in diabetic patients.AimTo evaluate the association between statin treatment and Chronic Kidney Disease in DM patients.MethodsThis is a retrospective disproportionality analysis and cohort study based on real-world data. All DM cases reported in US Food and Drug Administration adverse event reporting system (FAERS) between the first quarter of 2004 and the fourth quarter of 2022 were included. Disproportionality analyses were conducted by estimating the reporting odds ratio (ROR) and the information component (IC). We further compared the CKD odds ratio (OR) between the statins group and the other primary suspected drug group among the included diabetes mellitus cases.ResultsWe finally included 593647 DM cases from FAERS, 5113 (5.31%) CKD cases in the statins group and 8810 (1.77%) CKD cases in the control group. Data analysis showed that the statins group showed a significant CKD signal (ROR: 3.11, 95% CI: 3.00–3.22; IC: 1.18, 95% CI: 1.07–1.29). In case group with two or more statins treatment history, the CKD signal was even stronger (ROR: 19.56, 95% CI: 18.10–21.13; IC: 3.70, 95% CI:3.44–3.93) compared with cases with one statin treatment history.ConclusionThe impact of statin therapy on the progression of renal disease in individuals diagnosed with type 2 diabetes mellitus (DM) remains inconclusive. After data mining on the current FAERS dataset, we discovered significant signals between statin treatment and CKD in diabetic patients. Furthermore, the incidence rate of CKD was higher among DM patients who used statins compared to those who did not.
Repurposing effect of cardiovascular-metabolic drug to increase lifespan: a systematic review of animal studies and current clinical trial progress
Authors: Barinda Agian Jeffilano , Hardi Harri , Louisa Melva , Khatimah Nurul Gusti , Marliau Rheza Meida , Felix Immanuel , Fadhillah Muhamad Rizqy , Jamal Arief Kurniawan 
Published: June 2024

With the increase in life expectancy, aging has emerged as a significant health concern. Due to its various mechanisms of action, cardiometabolic drugs are often repurposed for other indications, including aging. This systematic review analyzed and highlighted the repositioning potential of cardiometabolic drugs to increase lifespan as an aging parameter in animal studies and supplemented by information from current clinical trial registries. Systematic searching in animal studies was performed based on PICO: “animal,” “cardiometabolic drug,” and “lifespan.” All clinical trial registries were also searched from the WHO International Clinical Trial Registry Platform (ICTRP). Analysis of 49 animal trials and 10 clinical trial registries show that various cardiovascular and metabolic drugs have the potential to target lifespan. Metformin, acarbose, and aspirin are the three most studied drugs in animal trials. Aspirin and acarbose are the promising ones, whereas metformin exhibits various results. In clinical trial registries, metformin, omega-3 fatty acid, acarbose, and atorvastatin are currently cardiometabolic drugs that are repurposed to target aging. Published clinical trial results show great potential for omega-3 and metformin in healthspan.Systematic Review Registration:crd.york.ac.uk/prospero/display_record.php?RecordID=457358, identifier: CRD42023457358.
CaMKIIδ-dependent dysregulation of atrial Na+ homeostasis promotes pro-arrhythmic activity in an obstructive sleep apnea mouse model
Authors: Hegner Philipp , Ofner Florian , Schaner Benedikt , Gugg Mathias , Trum Maximilian , Lauerer Anna-Maria , Maier Lars Siegfried , Arzt Michael , Lebek Simon , Wagner Stefan 
Published: June 2024

BackgroundObstructive sleep apnea (OSA) has been linked to various pathologies, including arrhythmias such as atrial fibrillation. Specific treatment options for OSA are mainly limited to symptomatic approaches. We previously showed that increased production of reactive oxygen species (ROS) stimulates late sodium current through the voltage-dependent Na+ channels via Ca2+/calmodulin-dependent protein kinase IIδ (CaMKIIδ), thereby increasing the propensity for arrhythmias. However, the impact on atrial intracellular Na+ homeostasis has never been demonstrated. Moreover, the patients often exhibit a broad range of comorbidities, making it difficult to ascertain the effects of OSA alone.ObjectiveWe analyzed the effects of OSA on ROS production, cytosolic Na+ level, and rate of spontaneous arrhythmia in atrial cardiomyocytes isolated from an OSA mouse model free from comorbidities.MethodsOSA was induced in C57BL/6 wild-type and CaMKIIδ-knockout mice by polytetrafluorethylene (PTFE) injection into the tongue. After 8 weeks, their atrial cardiomyocytes were analyzed for cytosolic and mitochondrial ROS production via laser-scanning confocal microscopy. Quantifications of the cytosolic Na+ concentration and arrhythmia were performed by epifluorescence microscopy.ResultsPTFE treatment resulted in increased cytosolic and mitochondrial ROS production. Importantly, the cytosolic Na+ concentration was dramatically increased at various stimulation frequencies in the PTFE-treated mice, while the CaMKIIδ-knockout mice were protected. Accordingly, the rate of spontaneous Ca2+ release events increased in the wild-type PTFE mice while being impeded in the CaMKIIδ-knockout mice.ConclusionAtrial Na+ concentration and propensity for spontaneous Ca2+ release events were higher in an OSA mouse model in a CaMKIIδ-dependent manner, which could have therapeutic implications.
Enhancing plant resilience: arbuscular mycorrhizal fungi’s role in alleviating drought stress in vegetation concrete
Authors: Guo Shiwei , Xia Lu , Xia Dong , Li Mingyi , Xu Wennian , Liu Liming 
Published: June 2024

IntroductionDrought stress usually inhibits plant growth, which may increase the difficulty of greening slopes.MethodsIn this study, we systematically investigated the effects of arbuscular mycorrhizal (AM) fungi on the growth and drought tolerance of two plant species, Festuca elata and Cassia glauca, in a vegetation concrete environment by exogenously inoculating AM fungi and setting three drought levels: well water, moderate drought and severe drought. The results showed that plant growth was significantly inhibited under drought stress; however, AM fungi inoculation significantly promoted plant height, root length, and above- and belowground biomass in these two plant species.ResultsCompared with, those in the CK treatment, the greatest increases in the net photosynthesis rate, stomatal conductance and transpiration rate in the AM treatment group were 36.72%, 210.08%, and 66.41%, respectively. Moreover, inoculation with AM fungi increased plant superoxide dismutase and catalase activities by 4.70–150.73% and 9.10–95.70%, respectively, and reduced leaf malondialdehyde content by 2.79–55.01%, which alleviated the damage caused by oxidative stress. These effects alleviated the damage caused by oxidative stress and increased the content of soluble sugars and soluble proteins in plant leaves by 1.52–65.44% and 4.67–97.54%, respectively, which further increased the drought adaptability of plants. However, inoculation with AM fungi had different effects on different plants.ConclusionIn summary, this study demonstrated that the inoculation of AM fungi in vegetation concrete environments can significantly increase plant growth and drought tolerance. The plants that formed a symbiotic structure with AM fungi had a larger root uptake area, greater water uptake capacity, and greater photosynthesis and gas exchange efficiency. In addition, AM fungi inoculation further increased the drought adaptability of the plants by increasing their antioxidant enzyme activity and regulating their metabolite content. These findings are highly important for promoting plant growth and increasing drought tolerance under drought conditions, especially for potential practical applications in areas such as slope protection, and provide useful references for future ecological engineering and sustainable development.