bluuebunny/crossref_metadata_2025_split huggingface dataset:
Écrire pour le théâtre : modes de production et professionnalisation de l’auteur de théâtre brésilien dans la première moitié du XXe siècle
Authors: Vertchenko Henrique Brener 
Published: May 2024

Occupant une position fondamentale dans les circuits de production et de transmission de textes pour le monde du spectacle, l’auteur de théâtre au Brésil a développé, dans les premières décennies du XXe siècle, des pratiques d’écriture uniques. Pour comprendre ce que signifiait alors écrire pour le théâtre, nous analyserons les conditions de base dans lesquels ce métier était exercé – avec la production de pièces à un rythme presque industriel –, ainsi que l’insertion des auteurs dans le milieu intellectuel et les ressorts de leur professionnalisation croissante.
Affinités futuristes : Aldo Palazzeschi dans la bibliothèque de Mário de Andrade
Authors: Klein Adriana Iozzi , Stefani Cláudia , Hass Juliana , Jesus Maurício Paschoareli de 
Published: May 2024

Cet article traite de la relation entre le modernisme de Mário de Andrade et le futurisme d’Aldo Palazzeschi à travers l’étude d’ouvrages présents dans la bibliothèque de l’auteur brésilien et de certains de ses écrits publiés au tournant des années 1920. L’analyse d’une partie de ce vaste corpus montre que Mário de Andrade a lu attentivement des œuvres de Palazzeschi telles que L’Incendiario et Il Codice di Perelà, parues à l’époque où l’auteur florentin était lié aux futuristes, et qu’il s’est reconnu dans des prémisses structurant ces productions. Il s’agit ici des premiers résultats d’une étude en cours, qui retrace les connexions entre futurisme italien et modernisme brésilien et témoigne du dialogue, encore peu exploré, entre deux auteurs fondamentaux pour la construction esthétique au sein des avant-gardes du XXe siècle.
« Nous nous voulons vivantes, libres et sans peur » : une analyse du processus d’adoption de la loi Maria da Penha au Congrès national brésilien
Authors: Sanchez Beatriz Rodrigues 
Published: May 2024

Comment fonctionne le lien entre la présence de femmes au parlement et l’approbation de projets de loi en faveur de l’égalité de genre ? Pour répondre à cette question, je me suis intéressée au processus d’adoption de la Loi Maria da Penha au Congrès national du Brésil. Sur le plan méthodologique, j’ai réalisé une étude de cas en m’appuyant sur l’analyse de documents et d’entretiens. Celle-ci a permis d’identifier des mécanismes qui contribuent à articuler la représentation descriptive et la représentation substantive des femmes. Parmi ces mécanismes figurent : la capacité à traduire les demandes des mouvements en normes juridiques, le soutien du pouvoir exécutif, la formation de coalitions majoritaires au sein du pouvoir législatif, l’implication des mouvements féministes dans la défense de la proposition et l’occupation par des fémocrates de fonctions de leadership au sein du parlement.
Activités saunières et artisanat des alliages cuivreux à la transition des deux âges du Fer sur le littoral atlantique : le Parc Savari à Guérande, Loire-Atlantique
Authors: Bellanger Patrick , Cornec Joël 
Published: May 2024

L’opération de fouille archéologique préventive conduite en 2008 sur une surface d’environ 16 000 m² a mis au jour des vestiges dont la chronologie comprend le Néolithique moyen la transition entre le premier et le second âge du Fer et plus succinctement La Tène finale et l’Antiquité.La principale phase d’occupation se caractérise par un site d’habitat implanté en tête de vallon et daté de la transition entre le Hallstatt final et La Tène ancienne. De nombreux vestiges attribués à cette période ont été découverts : probables bâtiments d’habitation, greniers et constructions diverses, lambeaux de sols, chemins, enclos, foyers, structures de combustion à vocation vraisemblablement artisanale et structures liées à une production salicole. Le mobilier collecté, tant domestique (céramiques, une cuillère ou un creuset en terre cuite, un fragment de bracelet en schiste) qu’artisanal (éléments de briquetage, fragments de tuyères, moules de bronzier, fusaïoles), ainsi que les données paléoenvironnementales fournies par les analyses palynologiques témoignent de l’intérêt scientifique du site du Parc Savari.
Nurse Educators, Clinical Nurses and Students’ Knowledge, Attitude and Practice towards Nursing Education in Bhutan
Authors: Moktan Manikala , Devi Elsa Sanatombi 
Published: May 2024

Abstract

Background:
In Bhutan, the Health School started in 1972 providing a 2-year certificate course for community health workers, assistant nurses and assistant technicians. In 1982, the Diploma course for nurses commenced and was assisted by the RAK College of Nursing Faculty, New Delhi, India, in formalising the curriculum and also carried out the evaluation of the first batch of nursing students.

Objective:
The study assesses the knowledge, attitude and practice (KAP) of nurse educators (NEs), clinical nurses and students undergoing the Diploma in Nursing and Midwifery training towards nursing education in Bhutan.

Methods:
The methodology was a quantitative study using a self-administered questionnaire. The first section had demographic data, and the second had questions on KAP. The participants were NEs, students and clinical nurses. The study was done in the nursing institute, the national hospital and the district hospitals. The instrument, i.e. questionnaire, had a five-point Likert scale from ‘excellent, good, fair, poor, to very poor’

Results:
In the results, students rated the KAP of NEs and clinical nurses as ‘good’. On the contrary, the attitude of students towards ‘gaining knowledge from the clinical area’ and their ‘eagerness to learn nursing’ are rated ‘fair’

Conclusion:
The KAP provides a detailed view of the status of nursing education, and the data obtained from the study provide strong baseline information for nursing education in the future.
Tissue microarray based immunohistochemical study of TLE1 in synovial sarcoma and its histologic mimics
Authors: Sivakoti Sumitra , Uppin Shantveer G , Uppin Megha S , Tara Roshini P , Prayaga Aruna k. , Challa Sundaram 
Published: May 2024

Background and Aims:
Molecular analysis is gold standard for diagnosis of synovial sarcoma (SS) but use of these ancillary techniques is limited by many practical issues like cost and limited resources. Several studies analyzed TLE1 as a diagnostic immunohistochemical marker for synovial sarcoma and few studies disagreed. The objective of the study was to evaluate immunohistochemical expression of TLE1 in synovial sarcoma and its histological mimics.

Methods:
The study included a total of 63 cases; of which 28 were synovial sarcomas (SS) and 35 its histologic mimics. A tissue microarray was constructed from these cases and subjected to TLE immunostaining. Nuclear immunoreactivity of TLE1 was graded as 0, 1+, 2+ and 3+ based on intensity and percentage of cells.

Results:
All SS except one (27/28; 96.4%) were positive for TLE 1. These included 18 of monophasic spindle cell type (94.7%), 5 biphasic type (100%), followed by two each (100%) of poorly differentiated and calcifying type of SS. Of the other tumours 2 GISTs (50%), 2 haemangiopericytoma (66.7%), 2 schwannomas (50%) and one mesenchymal chondrosarcoma (33.3%) were positive for TLE1.

Conclusion:
TLE 1 is a highly sensitive marker with reasonable specificity for synovial sarcoma. Awareness of TLE1 expression in other tumours, is important to avoid misdiagnosis.
Malignant mesothelioma
Authors: Patel Tarang , Aswal Priyanka 
Published: May 2024

Introduction:
Malignant mesothelioma is an aggressive neoplasm arising from serosal lining and has a poor prognosis. Definite diagnosis requires confirmation through a biopsy; however, it is sometimes difficult on microscopic evaluation alone and requires the use of a wide panel of immunohistochemical markers. So, immunohistochemistry (IHC) is of paramount importance and must be routinely used for a definite diagnosis. Till date, very few studies on morphology and detailed IHC markers of mesothelioma have been reported from India.

Aims:
To analyze the histomorphological findings of malignant mesothelioma, study the utility and role of the various immunohistochemical markers.

Material and Methods:
A total of 76 cases of mesotheliomas diagnosed at a tertiary cancer center in Udaipur were analyzed retrospectively from January 2015 to January 2020. Comprehensive data were analyzed including demographic, clinical, radiological, histopathological features along with a wide panel of IHC markers.

Results:
Mesothelioma occurs over a wide age range from 40 to 70 years. It most commonly involved pleura in 68 cases (89.47%) with very few cases from the peritoneum. On computed tomography (CT) scan, nodular pleural or peritoneal thickening was present. On microscopy, the most common histopathological type was epithelioid mesothelioma (58 cases, 74.3%) followed by sarcomatous (9 cases, 12.8%), deciduoid (6 cases, 8.6%), and 3 cases of biphasic (4.3%). On IHC, WT1, mesothelin, and calretinin markers were positive in 85.91%, 80%, and 93.33% cases of mesothelioma, respectively. Other markers were helpful to rule out differential diagnosis in difficult scenarios.

Conclusion:
Therefore, the correlation of histopathology with clinico-radiological findings and judicious use of a panel of IHC markers is required for routine evaluation and definite diagnosis. IHC is also useful in situations with similar morphological spectrum in specific locations.
MUC1, CK20, and CDX2 immunohistochemical markers can sub-classify periampullary carcinomas into pancreaticobiliary, intestinal, and mixed subtypes
Authors: Manohar K. Murali , Sasikala M. , Anuradha S. , Ramji C. , Sashidhar R. B. , Rao G. V. , Pradeep R. , Reddy D. Nageshwar 
Published: May 2024

Introduction:
Pancreaticobiliary subtype of Periampullary carcinoma (PAC) has a poor prognosis in comparison to the intestinal subtype. We assessed the potential of cytokeratins and mucin markers to classify the sub-types of periampullary tumors and compared them with the survival data to identify markers that may predict prognosis.

Methodology:
PAC tumor tissues were obtained from 94 patients undergoing Whipples Pancreaticoduodenectomy. Paraffin-embedded tissues were immunostained with cytokeratins CK7, CK20), mucins (MUC1, MUC2, MUC5Ac), and CDX2 antibodies. The survival status of patients was obtained as follow-up up to 5-years of surgery. The Receiver Operating Character Curve (ROC) analysis was used for detecting sensitivity and specificity. The survival data were analyzed using the Kaplan-Meier survival curve.

Results:
Tumors were initially categorized on the basis of histological classification as pancreaticobiliary (n = 46), intestinal (n = 35) and indeterminate (n = 13). Further, using immunohistochemical markers (MUC1, CK20, and CDX2), we gave systematic classification of IHC-PB (n = 51), IHC-Int (n = 30) and IHC-Mixed (n = 13). The interobserver analysis showed good agreement between histologic and IHC type with a kappa value of 0.554. Combined expression of CK20, MUC1 and CDX2 accurately classify the mixed type of tumor. Overall survival rate and duration were 74.4% and 44.95 ± 2.29 months. Survival analysis for subtypes reveal, pancreaticobiliary tumors have low survival (27.9 ± 1.63 months) than mixed type (35.5 ± 0.45 months) and intestinal-type (52.92 ± 2.18 months). Among these, intestinal-type have better survival. Only TNM Stage III (tumor staging as per American Joint Committee on Cancer classification) and perineural invasion have been associated with predicting poor survival in PAC patients.

Conclusion:
Our results suggest that the combined expression of MUC1, CK20 and CDX2 could serve as markers to diagnose histological inconclusive specimens as mixed subtype tumors.
Comparative analysis of chromogenic vs clot.based one stage APTT assay for determination of factor VIII level
Authors: Baig Mirza Asif , Swamy KB 
Published: May 2024

Background:
In the laboratory, factor VIII can be measured by three different methodologies, such as one-stage clotting assay, two-stage clotting assay, and chromogenic assay. These assays differ in ease of use, variety of reagents available, sensitivity to mild hemophilia A, and interference from lupus anticoagulants (LACs). Certain factor VIII gene mutations can cause discrepancy in results between one-stage activated partial thromboplastin time (APTT) and chromogenic assays.

Materials and Methods:
The coagulometer for factor VIII assay is Sysmex CS-5100. All data were expressed as mean ± standard deviation (SD).

Results:
A total of 135 cases were studied. Of these, 100 cases were of mild hemophilia A diagnosed by molecular genetics and, 15 cases were positive for LAC, which were confirmed by dilute Russell Viper venom test. Clot-based one-stage APTT assay showed 65% sensitivity and 80% specificity in diagnosing mild hemophilia A cases and out of 15 LAC cases, it showed false positivity in five cases. Chromogenic assay showed 85% sensitivity and 90% specificity in diagnosing mild hemophilia cases and was 100% specific in excluding LAC cases.

Conclusions:
One-stage APTT assay is the most commonly used test for determining factor VIII levels but chromogenic assay are considered as the gold standard and recommended as the reference method by European Pharmacopoeia and ISTH subcommittee. Mild hemophilia A patients with missense mutations show discrepancy between the one-stage clot-based APTT assay and chromogenic assays for determination of factor VIII level and this can lead to misdiagnosis or misclassification of mild hemophilia A. Therefore, it is recommended that both the assays should be used in the evaluation of mild hemophilia cases.
Effect of Spectrally Modified Speech on Speech Perception of Native Speakers of Marathi
Authors: Rathna Kumar S. B. , Patil Prajakta Prafulla , Saxena Udit , Bapuji Mendem , Chacko Gish 
Published: May 2024

Objective:
We investigated the effect of spectrally modified speech on speech perception of native speakers of Marathi.

Methods:
A total of eight word-lists with each list consisting of 25 words in Marathi were used as speech stimuli. The speech stimuli in List 1, List 2, List 3, List 4, List 5, List 6, and List 7 were spectrally modified by filtering them at 500 Hz, 1000 Hz, 1500 Hz, 2000 Hz, 2500 Hz, 3000 Hz, and 3500 Hz cutoff frequencies, respectively. The speech stimuli in List 8 were unfiltered. The speech identification score (SIS) testing was performed as a measure of speech perception using eight word-lists on a total of 125 normal hearing native speakers of Marathi in the age range between 18 and 25 years.

Results:
The results revealed that there was a statistically significant effect of spectral modification on speech perception. An increase in cutoff frequency of speech stimuli was analogous to increase in speech perception performance. The normal range of SIS (90%–100%) was achieved for speech stimuli filtered at 2500 Hz cutoff frequency.

Conclusion:
Although speech is a broadband signal, the findings of this study suggest that the spectral information till 2500 Hz is sufficient for optimum perception of speech of Marathi.
Canalplasty in Tympanoplasty – Functional and Surgical Outcome
Authors: Verma Ravneet Ravinder , Verma Ravinder 
Published: May 2024

Background:
During repair of central perforations of tympanic membrane, annulus should be visible in a single view. It helps in better placement of graft. To attain this, the bony canal is enlarged.

Materials and Methods:
Eighty patients with dry central perforation were selected during the period 2010–2020. Sixty patients with dry central perforation underwent tympanoplasty Type 1 with canalplasty and twenty patients were subjected to tympanoplasty Type 1 only. The method, operative procedure, and words of wisdom to give good results and prevent complications are described.

Results:
Patients with canalplasty had better postoperative results, and the success rate is improved as compared to only myringoplasty. The primary outcome measure of canalplasty with tympanoplasty procedure is complete re-epithelization and provision of a dry ear in 95%, whereas the final outcome without canalplasty was 90%.

Conclusion:
The aim of the canalplasty is to create a wide, patent, and physiological bony ear canal. Canalplasty helps to have better visualization, better postoperative care, better exposure for ossiculoplasty, time gain during graft placement, prevent lateralization, and promotes healing. It does improve the surgical outcome in tympanoplasty Type I.
A Comparative Study between Topical Versus Combined (Systemic Plus Topical) Therapy in Ciprofloxacin-Sensitive Chronic Suppurative Otitis Media (Tubotympanic)
Authors: Parmar Sandip M. , Chauhan Sapna , Mittal Shweta , Chaudhary Meenu 
Published: May 2024

Introduction:
Chronic suppurative otitis media (CSOM) is defined as a chronic inflammation of the middle ear and mastoid cavity, which presents with recurrent ear discharge or otorrhea through a tympanic perforation.

Aim:
The study aimed to compare the effectiveness of topical versus combined (systemic and topical) therapy in ciprofloxacin-sensitive CSOM (tubotympanic).

Materials and Methods:
A hospital-based prospective study of 100 patients aged >18 years with clinically diagnosed CSOM (tubotympanic type) was conducted. After aural toilet, patients were randomly assigned to one of the two treatment groups: Group A (topical ciprofloxacin ear drops) Group B (topical plus oral ciprofloxacin). These patients were received 1 week of treatment and followed up on day 3 and day 7. Statistical comparisons were performed using Chi-square test.

Results:
In this study, maximum numbers of patients were found in the age group of 20–29 years. Patients in Group A (topical ciprofloxacin ear drops) showed less side effects in comparison to Group B (topical plus oral ciprofloxacin). Forty-one (82%) patients showed improvement in Group A, whereas 43 (86%) patients in Group B.

Conclusion:
Topical ciprofloxacin drops were as effective as combined (oral plus topical ciprofloxacin) and that the addition of oral drug did not have any beneficial effect adding only to the side effects and to the cost of treatment.
Utricular Dysfunction by Subjective Visual Vertical after Canalolith Repositioning Maneuvers for Posterior Semicircular Canal Benign Paroxysmal Positional Vertigo
Authors: Sanji Rajiv Ranganath , Patil Sanjay B. , Channegowda Chandrakiran , Ishwarya R. , Rakshitha R. 
Published: May 2024

Introduction:
Residual vestibular dysfunction is a common sequela of benign paroxysmal positional vertigo (BPPV), causing morbidity even after the resolution of vertigo with otolith repositioning maneuvers. The subjective visual vertical (SVV) measurement is used to detect the vertical spatial disorientation which may be associated with utricular dysfunction. We used the bucket test to measure possible residual utricular dysfunction in patients with BPPV after successful treatment of BPPV with canalolith repositioning maneuvers.

Objective:
(1) To document the presence of utricular dysfunction after canalolith repositioning maneuvers for posterior semicircular canal BPPV using bucket test for SVV. (2) To compare the difference in residual utricular dysfunction represented by SVV after Epley's and Semont's maneuvers.

Study Design:
Prospective, clinical, single center, cross sectional study. Methods: Sixteen consecutive patients attending ENT OPD at a tertiary care hospital for canalolith repositioning maneuvers for posterior semi circular canal BPPV underwent bucket test for SVV on the first follow up after a single physician directed maneuver for the correction of BPPV.

Results:
Sixteen bucket test results were analyzed after repositioning manoeuvres – twelve of which were Epley's maneuver and four were Semont's maneuver. Fourteen had a deviation of SVV more than 2° s. There was a significantly lower mean deviation of SVV following Semont's maneuver versus Epley's maneuver.

Conclusion:
There is a residual vertical spatial disorientation following repositioning maneuvers which contributes to dizziness after treatment. Our new finding was a lower mean deviation in SVV after Semont's compared to Epley's maneuver. Larger studies are required to confirm our findings with better statistical weight.
Managing Eustachian Tube Dysfunction with Balloon Catheterization
Authors: Tan ST , Hashim Noor Dina , Abdullah Asma 
Published: May 2024

Objective:
Eustachian tube dysfunction (ETD) is not commonly acknowledged until it leads to sequelae within the middle ear. Thus, treatments are focusing on treating active middle ear diseases repetitively rather than identifying possible fundamental causes. This study aims to report a preliminary local experience in treating ETD using balloon dilatation.

Methods:
This prospective, randomized controlled study was conducted in a tertiary academic center. Sixteen patients who were identified with symptoms of ETD were recruited. Six who had failed initial medical therapy underwent balloon dilatation of Eustachian tube (BDET); meanwhile, ten subjects were recruited into the medical treatment group. The primary efficacy endpoint was the comparison of reduction from baseline in overall 7-item Eustachian Tube Dysfunction Questionnaire (ETDQ-7) score. Added endpoints were normalization of tympanogram and improvement of tympanic membrane appearance at 2 weeks, 6 weeks, and 3 months after intervention.

Results:
The median in reduction of overall ETDQ-7 score for the interventional group was 2.93 (2.14, 3.14) versus 0.43 (0, 0.86) for the control group. Reduction in overall ETDQ-7 score showed a significant improvement at 6 weeks which was persistent at 3 months post balloon dilatation (P < 0.05). Similarly, the BDET group demonstrated changes in tympanogram at 6 weeks and 3 months post balloon dilatation (P < 0.05). Tympanic membrane appearances were similar at the end of the study in both the groups.

Conclusion:
BDET is a promising precise treatment for patients who present with symptoms of ETD. The improvement of symptoms it provides may increase the readiness for it to be introduced as a standard practice in local settings and beyond.
Correlation of Eustachian Tube Dimension and Chronic Otitis Media
Authors: Varghese Sherin , Goutham MK , Saldanha Marina , Aroor Rajeshwary , Uppoor Raghuraj , Bhat Vadisha Srinivas 
Published: May 2024

Background:
Eustachian tube (ET) is a dynamically intricate and poorly accessible structure connecting the nose and the middle ear. Although chronic otitis media (COM) is multifactorial disease, ET dysfunction is an important but overlooked predisposing factor. With newer evidence into the dynamics and prognostic factor in outcome of middle ear surgeries, it has become a focus of research. Our study aims to evaluate the various ET parameters using high-resolution computed tomography (HRCT) scan with multiplanar reconstruction technique. These parameters were compared between the diseased and normal ears to evaluate any association between the ET parameters and middle ear disease.

Materials and Methods:
It is a retrospective study of 66 HRCTs, with 47 HRCTs of COM and rest were controls. ET parameters including (a) ET-angle, (b) length, (c) pretympanic diameter, and (d) diameter at isthmus are measured accurately using HRCT temporal bone.

Results:
ET angle was significantly obtuse in COM group (154.81° ± 6.33°) when compared with the controls (149.99° ± 6.24°) with P < 0.001. Similar observation in ET angle was noted in diseased ear (154.54° ± 5.79°) in unilateral COM when compared with contralateral ear (149.56° ± 6.87°) (P = 0.001). ET was longer in COM group (3.44 ± 0.31) when compared with controls (3.4 ± 0.35). Pretympanic diameter and diameter at isthmus were greater in control group.

Conclusion:
The obtuse ET angle and narrow pretympanic diameter may contribute to the pathogenesis of COM. These measurements may be useful in the assessment of ET function preoperatively and might help in determining the surgical outcome. HRCT of temporal bone with multiplanar reconstruction is an effective tool to measure ET dimensions accurately.