bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract
Authors: Mardeyanti Mardeyanti , Yulfitria Fauziah 
Published: May 2024

Background:Language ability is indicator for child development and will affect delays or damage to other systems because children's language skills also involve cognitive, motoric, psychological, emotional, and environmental abilities. Right stimulation can improve children's language development. Language stimulation can be done by the mother. Objective: This study aims to determine the effect of maternal stimulation behavior on the language development of pre-school children. Methode: This research is a quantitative research with a cross sectional approach. The population in this study amounted to 50 people with sampling using total sampling technique. Data analysis was processed using chi-square. Results: The results showed the correlation between knowledge and children's language development (p = 0.002), attitude and language development (p = 0.003), behavior (p = 0.005). Conclusion: Based on this analysis, it was found that there is a correlation between mother's knowledge, attitudes and behavior with language development
New requirements of the RF legislation on the use of secondary resources and raw materials in cement production
Authors: Озерова Е.М. 
Published: May 2024

Законодательство РФ несколько последних лет реализует цель Федерального закона от 24 июня 1998 года № 89-ФЗ «Об отходах производства и потребления» — вовлечение отходов в хозяйственный оборот. Одним из первых направлений, реализованных в цементной промышленности, стало применение твердого топлива, полученного из отходов, возможность сжигания которого в цементных печах была закреплена еще в первой редакции информационно-технического справочника по наилучшим доступным технологиям ИТС 6—2015 «Производство цемента». Такое топливо успешно применяется на предприятиях ряда цементных холдингов, соответствующую работу ведут и другие производители цемента. Вопросы подготовки альтернативного топлива из твердых коммунальных отходов освещены в технологическом стандарте ППК РЭО № 94 от 30 июля 2021 года «Обращение с твердыми коммунальными отходами. Методы и технологии подготовки альтернативного топлива из твердых коммунальных отходов»
The legislation of the Russian Federation for the last few years has been pursuing the goal of the Federal Law No. 89-FZ dated June 24, 1998 “On produc-tion and consumption wastes”, i.e. involvement of wastes into economic circulation. One of the first areas in the cement industry was the use of solid fuel derived from waste, the possibility of its combustion in cement kilns was recognized in the first edition of the information and technical reference book on the best available practices ITS 6-2015 “Cement Production”. Such fuel is successfully used at the plants of a number of cement manufacturing companies, and other cement producers are also engaged in the relevant work. The issues of obtaining alternative fuel from solid municipal waste are covered in the industrial standard CPC REO No. 94 dated July 30, 2021 “Solid municipal waste management. Methods and technologies for preparing alternative fuel from solid municipal waste”.
Properties of geopolymer cement based on thermally activated clays
Authors: Смольская Е.А. , Потапова Е.Н. , Сивков С.П. , Корчунов И.В. 
Published: May 2024

В статье рассмотрено влияние термоактивированных глин на свойства портландцемента. Показано, что термоактивированные глины могут заменить до 25 % портландцементного клинкера без потерь прочности и качества цемента, что позволило бы снизить выбросы углекислого газа при производстве цемента.
The article examines the effect of thermally activated clays on the properties of Portland cement. It is shown that thermally activated clays can replace up to 25 % of Portland cement clinker without loss of strength and cement quality, which will reduce carbon dioxide emissions during cement production
Alteration of RNA m6A methylation mediates aberrant RNA binding protein expression and alternative splicing in condyloma acuminatum
Authors: Liu Xiaoyan , Xie Bo , Wang Su , Wu Yinhua , Zhang Yu , Ruan Liming 
Published: May 2024

Background
Condyloma acuminatum (CA) is caused by low-risk human papillomavirus, and is characterized by high recurrence after treatment. The RNA modification N6-methyladenosine (m6A) plays an important role during diverse viral infections, including high-risk HPV infection in cervical cancer. However, it is unclear whether low-risk HPV infection changes the RNA m6A methylation in CA.

Methods
High-throughputm6A-sequencing was performed to profile the transcriptome-wide mRNA modifications of CA tissues infected by LR-HPVs and the paired normal tissues from CA patients. We further investigated the regulation of alternative splicing by RNA binding proteins (RBPs) with altered m6A modification and constructed a regulatory network among these RBPs, regulated alternative splicing events (RASEs) and regulated alternative splicing genes (RASGs) in CA.

Results
The results show that the m6A level in CA tissues differed from that in the paired controls. Furthermore, cell cycle- and cell adhesion- associated genes with m6A modification were differentially expressed in CA tissues compared to the paired controls. In particular, seven RNA binding protein genes with specific m6A methylated sites, showed a higher or lower expression at the mRNA level in CA tissues than in the paired normal tissues. In addition, these differentially expressed RNA binding protein genes would regulate the alternative splicing pattern of apoptotic process genes in CA tissue.

Conclusions
Our study reveals a sophisticated m6A modification profile in CA tissue that affects the response of host cells to HPV infection, and provides cues for the further exploration of the roles of m6A and the development of a novel treatment strategy for CA.
Recent Developments Toward the Application of Iron Aluminides in Fossil Fuel Technologies
Authors: Morris David G. , Muñoz‐Morris Maria A. 
Published: November 2010

AbstractIron aluminides are of interest for applications in power generation from fossil fuels because of excellent high temperature oxidation–corrosion resistance in aggressive environments and are potential replacements for high temperature steels. The Fe‐base composition ensures relative cheapness, while the high Al content leads to significant density reduction over commercial steels. Problems of low ductility/toughness at room temperature and poor high temperature (creep) strength, however, have prevented significant commercial use. After studies led by Oak Ridge National Laboratory (USA) from about 1980 to 2000, research has continued in Europe both as pan‐European efforts and as national efforts in countries such as the Czech Republic, France, Germany and Spain. An overview of such recent activities is presented, indicating the research strategies involved, and the progress toward making iron aluminides useful engineering materials. Recent activities have targeted microstructural refinement through novel processing to improve room temperature ductility or attempted alloying additions to improve high temperature strength. Achieving the required properties remains difficult, and has led to developments of iron aluminides as cast components and as coatings.
Birth weight and early socio‐economic disadvantage as predictors of sex hormones and sex hormone binding globulin in men at age 49–51 years
Authors: Pearce Mark S. , Groom Alix , Relton Caroline L. , Peaston Robert T. , Pollard Tessa M. , Francis Roger M. 
Published: November 2010

AbstractObjectives: A number of associations have been shown between early growth and later sex hormone levels in women, but less is known about this relationship in men. This study investigated lifecourse predictors of sex hormones in men in the Newcastle Thousand Families birth cohort.Methods: The Newcastle Thousand Families Study is a prospective study initiated in 1947. At age 49‐51 years, 574 study members returned detailed self‐completion questionnaires and 412 attended for clinical examination, including 172 men in whom blood samples were taken. Estradiol, follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and sex hormone binding globulin (SHBG) were measured. Free testosterone concentrations were also calculated.Results: Social class at birth independently predicted FSH and LH, with higher levels with increasing socioeconomic disadvantage. SHBG was higher with increasing standardized birth weight and lower with increasing contemporary body mass index (BMI). BMI also predicted LH, SHBG, and testosterone. None of the variables included within this analysis were significant predictors of estradiol. No other associations were seen with any of the variables included from across the lifecourse.Conclusions: Our findings suggest that birth weight may be positively associated with SHBG and early socioeconomic status may be related to FSH and LH in men. These novel findings are independent of contemporary BMI. Given the links between sex hormones, SHBG and disease outcomes such as type II diabetes and osteoporosis, it is possible that sex hormones may play a mediating role in the associations between circumstances in early life and later risk of chronic disease. Am. J. Hum. Biol., 2010. © 2010 Wiley‐Liss, Inc.
Factors associated with experiences of genetic discrimination among individuals at risk for huntington disease
Authors: Bombard Yvonne , Palin JoAnne , Friedman Jan M. , Veenstra Gerry , Creighton Susan , Paulsen Jane S. , Bottorff Joan L. , Hayden Michael R. ,   The Canadian Respond‐HD Collaborative Research Group
Published: November 2010

AbstractThe purpose of this study was to identify factors that are associated with experiencing genetic discrimination (GD) among individuals at risk for Huntington disease (HD). Multivariable logistic regression analysis was used to examine factors associated with experiencing GD in data from a cross‐sectional, self‐report survey of 293 individuals at risk for HD. The study sample comprised 167 genetically tested respondents, and 66 who were not tested (80% response rate). Overall, individuals who learn they are at risk for HD at a younger age (OR = 3.1; 95% CI: 1.5–6.2; P = 0.002), are mutation‐positive (OR = 2.8; 95% CI: 1.4–6.0; P = 0.006), or are highly educated (OR = 2.7; 95% CI: 1.4–5.1; P = 0.002) are more likely to experience GD, particularly in insurance, family, and social settings. Further, younger age was associated with discrimination in insurance (OR = 0.97; 95% CI: 0.94–1.00; P = 0.038). This study provides evidence that some people who are at risk for HD were more likely to experience GD than others. Individuals who learned they are at risk for HD at a younger age and those who are mutation‐positive were more likely to experience GD, particularly in insurance, family, and social settings. Younger individuals were more likely to experience discrimination in the insurance setting. Overall, highly educated individuals were also more likely to report discrimination. These results provide direction for clinical and family discussions, counseling practice, and policy aimed at mitigating experiences of GD. © 2010 Wiley‐Liss, Inc.
Great apes use weight as a cue to find hidden food
Authors: Schrauf Cornelia , Call Josep 
Published: November 2010

AbstractBonobos (Pan paniscus;n= 5), orangutans (Pongo pygmaeus abelii;n= 6), and a gorilla (Gorilla gorilla gorilla;n= 1) were presented with two opaque cups, one empty and one baited (containing two bananas). Subjects had to independently gain weight information about the contents of the cups to find the hidden food. Six apes attained above chance level within a total of 16 trials. Successful subjects spontaneously adopted the method of successively lifting the cups and thus comparing their weight before making a choice. Prior to testing, these apes had participated in a weight discrimination task. To rule out that a subject's good performance was influenced by previous experience in weight experiments, we ran a second test in which the same task was presented to a group of chimpanzees (Pan troglodytes;n= 9) who were naïve to weight experiments. These subjects also participated in an additional test condition in which the same problem was presented based on learning to associate arbitrary visual stimuli. The results show that experience did not affect performance because the nine naïve subjects were equally able to find the food when the task stimuli held a causal relation (i.e. weight indicates the hidden food). Interestingly, only one of the naïve subjects solved the task when the task elements held an arbitrary relation (i.e. certain visual pattern indicates food). Our results confirm previous findings that apes perform better in problems grounded on causal compared to arbitrary relations. Am. J. Primatol. 73:323–334, 2011. © 2010 Wiley‐Liss, Inc.
Quantitative assessment of interproximal wear facet outlines for the association of isolated molars
Authors: Benazzi Stefano , Fiorenza Luca , Katina Stanislav , Bruner Emiliano , Kullmer Ottmar 
Published: November 2010

AbstractThe determination of the minimum number of individuals can be very challenging, especially in an assemblage of fragmentary bones and isolated teeth. Similarities in tooth morphology, degree of wear, and interproximal wear facets (IPWF) are generally used to associate isolated teeth qualitatively. However, no quantitative method has yet been established for an objective identification and matching of isolated tooth crowns. In this study, we analyze the IPWF morphology of adjacent mandibular molars (17 M1/M2 pairs), applying both qualitative and quantitative methods to test a reproducible approach for crown association. The surfaces of distal (for M1) and mesial (for M2) IPWF were surface‐scanned and digitally selected. Three‐dimensional (3D) and two‐dimensional (2D) outlines of IPWF were analyzed using elliptic Fourier analysis (EFA) and geometric morphometrics methods (GMM). Additionally, teeth were qualitatively associated by visual evaluation of the IPWF outline and by physical matching. Unsatisfactory results with less than 50% of tooth pairs correctly associated were obtained by using both methods, shape analysis (digital approach) and the visual evaluation (qualitative assessment) of the IPWF outline. The physical matching of the crowns showed highly variable accuracy ranging between 53% and 77%. The quantitative form‐space analysis of 2D IPWF outlines provided the best results (82% of correctly associated teeth), but no statistically significant differences were recorded when compared with the manual matching. Since three tooth pairs out of 17 could not be quantitatively associated, we suggest that the quantitative analysis of IPWF should be used only in addition with other approaches.Am J Phys Anthropol, 2011. © 2010 Wiley‐Liss, Inc.
Assessment of Hydroxypropyl Methylcellulose, Propylene Glycol, Polysorbate 80, and Hydroxypropyl‐β‐Cyclodextrin for use in developmental and reproductive toxicology studies
Authors: Enright Brian P. , McIntyre Barry S. , Thackaberry Evan A. , Treinen Kimberley A. , Kopytek Stephan J. 
Published: November 2010

AbstractBACKGROUND: A series of studies were conducted to assess Polysorbate 80 (PS80), Propylene Glycol (PG), and Hydroxypropyl‐β‐Cyclodextrin (HPβCD), when compared with Hydroxypropyl Methylcellulose (MC) in developmental and reproductive toxicology (DART) studies. METHODS: In the rat fertility study, 20 mg/kg MC, 10 mg/kg PS80, 1,000 mg/kg PG, 500 mg/kg HPβCD or 1,000 mg/kg HPβCD were administered orally before/during mating, and on gestation Day (GD) 0–7, followed by an assessment of embryonic development on GD 14. In the rat and rabbit teratology studies, the doses of MC, PS80, PG, and HPβCD were the same as those in the fertility study. In these teratology studies, pregnant females were dosed during the period of organogenesis, followed by an assessment of fetal external, visceral, and skeletal development. RESULTS: In the rat fertility and rat teratology studies, PS80, PG, and HPβCD did not exhibit toxicity, when compared with MC. Similarly, in the rabbit teratology study, there was no PS80 or PG‐related toxicity, when compared with MC. However, individual rabbits in the 500 and 1,000 mg/kg HPβCD groups exhibited maternal toxicity, which included stool findings, decreased food consumption, and body weight gain. Furthermore, one rabbit each in the 500 and 1,000 mg/kg HPβCD groups exhibited evidence of abortion, which was considered secondary to maternal toxicity. CONCLUSIONS: Although HPβCD was not well tolerated in rabbits at doses of 500 and 1,000 mg/kg, PS80 and PG were comparable to MC and should be considered for use in developmental and reproductive toxicology studies. Birth Defects Res (Part B) 89:504–516,2010. © 2010 Wiley‐Liss, Inc.
Functional anatomy of the mandibular nerve: Consequences of nerve injury and entrapment
Authors: Piagkou Maria , Demesticha Theano , Skandalakis Panayiotis , Johnson Elizabeth O. 
Published: November 2010

AbstractVarious anatomic structures including bone, muscle, or fibrous bands may entrap and potentially compress branches of the mandibular nerve (MN). The infratemporal fossa is a common location for MN compression and one of the most difficult regions of the skull to access surgically. Other potential sites for entrapment of the MN and its branches include, a totally or partially ossified pterygospinous or pterygoalar ligament, a large lamina of the lateral plate of the pterygoid process, the medial fibers of the lower belly of the lateral pterygoid muscle and the inner fibers of the medial pterygoid muscle. The clinical consequences of MN entrapment are dependent upon which branches are compressed. Compression of the MN motor branches can lead to paresis or weakness in the innervated muscles, whereas compression of the sensory branches can provoke neuralgia or paresthesia. Compression of one of the major branches of the MN, the lingual nerve (LN), is associated with numbness, hypoesthesia, or even anesthesia of the tongue, loss of taste in the anterior two thirds of the tongue, anesthesia of the lingual gums, pain, and speech articulation disorders. The aim of this article is to review, the anatomy of the MN and its major branches with relation to their vulnerability to entrapment. Because the LN expresses an increased vulnerability to entrapment neuropathies as a result of its anatomical location, frequent variations, as well as from irregular osseous, fibrous, or muscular irregularities in the region of the infratemporal fossa, particular emphasis is placed on the LN. Clin. Anat. 24:143–150, 2011. © 2010 Wiley‐Liss, Inc.
1‐Cyclohexyl‐4‐(4‐arylcyclohexyl)piperazines: Mixed σ and Human Δ8–Δ7 Sterol Isomerase Ligands with Antiproliferative and P‐Glycoprotein Inhibitory Activity
Authors: Abate Carmen , Niso Mauro , Contino Marialessandra , Colabufo Nicola Antonio , Ferorelli Savina , Perrone Roberto , Berardi Francesco 
Published: November 2010

AbstractMany new chemotherapeutic agents are under preclinical investigation and, despite efforts to more selectively target cancer cells, limitations such as toxicity and inherent resistance are often encountered. Therefore, alternative strategies are needed to treat cancer and overcome such limitations. We describe novel cyclohexylpiperazine derivatives, designed as mixed affinity ligands for sigma (σ) receptors and human Δ8–Δ7 sterol isomerase (HSI) ligands, which also exhibit P‐glycoprotein (P‐gp) inhibitory activity, with the aim of exploiting the antiproliferative effects mediated by σ and HSI sites while overcoming P‐gp‐mediated resistance. All of the compounds displayed high affinities for σ receptors and HSI sites, P‐gp inhibitory activity, and σ2 receptor agonist antiproliferative activity. Antiproliferative activity was also tested in PC‐3 cells to establish σ1 and HSI contribution. Compound cis‐11, which displayed the best antiproliferative and P‐gp inhibitory activities, was co‐administered with 0.1 μM doxorubicin in MDCK‐MDR1 cells. Compound cis‐11 caused 70 % and 90 % cell death when co‐administered at 30 μM and 50 μm, respectively. When administered alone, cis‐11 resulted in 50 % cell death, demonstrating its single agent antitumor properties in a tumor cell line overexpressing P‐gp.
Motile ciliary microorganisms in peritoneal fluid
Authors: Vila Michael , Thompson Karen , Erdem Guliz 
Published: November 2010

AbstractWe report a patient with chronic renal failure and ciliocytophthoria or “detached ciliary tufts” identified from her peritoneal fluid. The recognition of these rare structures is critical to avoid misdiagnosing a presumed protozoan infection and embarking on further costly investigations and unnecessary treatments. Diagn. Cytopathol. 2011. © 2010 Wiley‐Liss, Inc.
Cytology‐based gene mutation tests to predict response to anti‐epidermal growth factor receptor therapy: A review
Authors: Malapelle Umberto , Bellevicine Claudio , Zeppa Pio , Palombini Lucio , Troncone Giancarlo 
Published: November 2010

AbstractRecent therapeutic progresses in nonsmall cell lung cancer (NSCLC) and in colorectal cancer (CRC) are based on agents that specifically target the epidermal growth factor receptor (EGFR). To identify the patients most likely to benefit from such therapies, EGFR or KRAS gene mutation tests are mandatory, respectively, in NSCLC and in CRC. In patients with locally advanced or metastatic disease, exploiting cytological samples for these tests avoids not curative surgery. Here, we review the studies that have applied gene mutation assays on cytological samples of NSCLC and CRC to select patients for anti‐EGFR therapy. We argue that the standard of quality of gene mutation tests on cytological samples is closely dependent on the extent of the cytopathologist's involvement. Diagn. Cytopathol. 2010. © 2010 Wiley‐Liss, Inc.
The prevalence of abnormal cervical cytology in women with systemic lupus erythematosus
Authors: AbdullGaffar Badr , AlSaleh Jamal , Hattawi Hussain 
Published: November 2010

AbstractTo compare the frequency of abnormal cervical cytology in women with systemic lupus erythematosus (SLE) with that of healthy women without connective tissue diseases by using ThinPrep® liquid based Pap TestsTM. A retrospective case‐control study over 2 years was conducted. The cases included all women with SLE who had Pap tests during their treatment period. The control group included all women without SLE or other connective tissue diseases (CTDs) that had routine Pap tests in the same period. The age and demographic features were adjusted and matched for both groups. Statistical analysis included Chi‐Square test and Fischer exact test. The SLE group (n= 55) showed significantly (P < 0.05) more abnormal cervical squamous epithelial abnormalities [14 positive cases (25.4%) than the controls (n = 8,175, with 285 positive cases (3.5%)]. Women with SLE had statistically significant higher frequency and prevalence of squamous intraepithelial lesions than women without SLE of similar age and demographic background. The data suggested that women with SLE might benefit from more frequent cervical cytology screening. Diagn. Cytopathol. 2010. © 2010 Wiley‐Liss, Inc.