bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge and factors associated with active management of the third stage of labor in sub‐Saharan Africa: A systematic review and meta‐analysis
Authors: Abebe Gelaw Kelemu , Atalay Yibeltal Assefa , Azeze Gedion Asnake , Yitayew Alemker Molla , Gebeyehu Natnael Atnafu 
Published: May 2024

AbstractBackgroundPostpartum hemorrhage (PPH) is one of the leading causes of maternal mortality in sub‐Saharan Africa. Implementing active management in the third stage of labor has significantly reduced the incidence of PPH. Thus, understanding the level of healthcare providers' knowledge of active management in the third stage of labor can inform guidelines, policies, and practices for effectively preventing PPH.ObjectiveThis review aimed to assess the level of healthcare providers' knowledge and associated factors of active management in the third stage of labor in sub‐Saharan Africa.Search StrategyWe conducted a search using PubMed, Scopus, Web of Science, Google Scholar, Cochrane Library, and the African Journals online international databases.Selection CriteriaThe inclusion criteria were determined before the review of the articles and adhere to the criteria of population, intervention, comparison, and outcome.Data Collection and AnalysisStatistical analysis was performed using STATA data analysis software version 14, while Microsoft Excel was utilized for data abstraction. We checked publication bias using a funnel plot and Egger and Begg regression tests. A P value less than 0.05 was considered statistically significant, suggesting the presence of presence publication bias. The I2 statistic was used to assess heterogeneity between studies. The study's overall effect was evaluated using the random effects model.Main ResultThe study included 20 studies to conduct a pooled prevalence analysis. The overall prevalence of healthcare providers' knowledge of active management of third‐stage labor in sub‐Saharan Africa was 47.975% (95% CI: 32.585, 63.365). Having pre‐ and in‐service training (AOR: 2.25, 95% CI: 1.00, 5.08), having a higher degree (AOR: 1.98, 95% CI: 1.39, 2.82), and having good practices (AOR: 8.91, 95% CI: 4.58, 17.40) were significantly associated with healthcare provider's knowledge regarding active management third stage of labor.ConclusionsThe overall healthcare providers' knowledge of active management of the third stage of labor (AMTSL) was low in sub‐Saharan Africa. Obstetric healthcare providers should undertake comprehensive training covering all AMTSL components through pre‐ and in‐service diploma training programs.
Emerging near‐infrared luminescent materials for next‐generation broadband optical communications
Authors: Xu Beibei , Jin Chaoyuan , Park Jae‐Seong , Liu Huiyun , Lin Xing , Cui Junjie , Chen Daoyuan , Qiu Jianrong 
Published: May 2024

AbstractThe rapid development of emerging technologies observed in recent years, such as artificial intelligence, machine learning, mobile internet, big data, cloud computing, and the Internet of Everything, are generating escalating demands for expanding the capacity density, and speed in next‐generation optical communications. This poses a significant challenge to existing communication techniques. Within this context, the integration of near‐infrared broadband, tunable, and high‐gain luminescent materials into silicon optical circuits or fiber architectures to transmit and modulate light shows enormous potential for advancing next‐generation communication techniques. Here, this review provides an overview of the recent breakthroughs in near‐infrared luminescent epitaxial/colloidal quantum dots, and metal‐active‐center‐doped materials for broadband optical amplifiers and tunable lasers. We also expound on efforts to enhance the bandwidth and gain of these materials‐based amplifiers and lasers, exploring the challenges associate with developing ultra‐broadband and high‐speed optical communication systems. Additionally, the potential applications in Fifth Generation Fixed Networks, integration with 5G and 6G wireless networks, compensation for current Si electronic based CMOS for high computing capability, and the prospects of these light sources for next‐generation optoelectronic devices are discussed.image
Bafi A1 inhibits nano‐copper oxide‐induced mitochondrial damage by reducing the release of copper from lysosomes
Authors: Huang Zhi , Lin Mo , Wang Lei , Dou Liangding , Hou Xin , Zhang Jinwen , Huang Yongchao , Wei Lifang , An Ran , Wang Dai , Yao Youliang , Guo Dongbei , Li Zhibo , Zhang Yongxing 
Published: May 2024

AbstractThis study demonstrated that both copper oxide nanoparticles (CuO‐NPs) and copper nanoparticles (Cu‐NPs) can cause swelling, inflammation, and cause damage to the mitochondria of alveolar type II epithelial cells in mice. Cellular examinations indicated that both CuO‐NPs and Cu‐NPs can reduce cell viability and harm the mitochondria of human bronchial epithelial cells, particularly Beas‐2B cells. However, it is clear that CuO‐NPs exhibit a more pronounced detrimental effect compared with Cu‐NPs. Using bafilomycin A1 (Bafi A1), an inhibitor of lysosomal acidification, was found to enhance cell viability and alleviate mitochondrial damage caused by CuO‐NPs. Additionally, Bafi A1 also reduces the accumulation of dihydrolipoamide S‐acetyltransferase (DLAT), a marker for mitochondrial protein toxicity, induced by CuO‐NPs. This observation suggests that the toxicity of CuO‐NPs depends on the distribution of copper particles within cells, a process facilitated by the acidic environment of lysosomes. The release of copper ions is thought to be triggered by the acidic conditions within lysosomes, which aligns with the lysosomal Trojan horse mechanism. However, this association does not seem to be evident with Cu‐NPs.
Microvesicles derived from dermal myofibroblasts modify the integrity of the blood and lymphatic barriers using distinct endocytosis pathways
Authors: Arif Syrine , Richer Megan , Larochelle Sébastien , Moulin Véronique J. 
Published: May 2024

AbstractMicrovesicles (MVs) are a subtype of extracellular vesicles that can transfer biological information from their producer cells to target cells. This communication can in turn affect both normal and pathological processes. Mounting evidence has revealed that dermal wound myofibroblasts (Wmyo) produce MVs, which can transfer biomolecules impacting receptor cells such as human dermal microvascular endothelial cells (HDMECs). While the effects of MVs on HDMECs are generally well described in the literature, little is known about the transport of MVs across the HDMEC barrier, and their potential effect on the barrier integrity remains unknown. Here, we investigated these roles of Wmyo‐derived MVs on two sub‐populations of HDMECs, blood endothelial cells (BECs) and lymphatic endothelial cells (LECs). Using an in vitro model to mimic the endothelial barrier, we showed that MVs crossed the LEC barrier but not the BEC barrier. In addition, we demonstrated that MVs were able to influence the cell‐cell junctions of HDMECs. Specifically, we observed that after internalization via the predominantly caveolin‐dependent pathway, MVs induced the opening of junctions in BECs. Conversely, in LECs, MVs mainly use the macropinocytosis pathway and induce closure of these junctions. Moreover, proteins in the MV membrane were responsible for this effect, but not specifically those belonging to the VEGF family. Finally, we found that once the LEC barrier permeability was reduced by MV stimuli, MVs ceased to cross the barrier. Conversely, when the BEC barrier was rendered permeable following stimulation with MVs, they were subsequently able to cross the barrier via the paracellular pathway. Taken together, these results suggest that the study of Wmyo‐derived MVs offers valuable insights into their interaction with the HDMEC barrier in the context of wound healing. They highlight the potential significance of these MVs in the overall process.
Epidemiological characteristics and antibody kinetics of elderly population with booster vaccination following both Omicron BA.5 and XBB waves in China
Authors: Zhao Xin‐Jing , Liu Xiao‐Lin , Liang Yu‐Min , Zhang Sheng , Liu Ti , Li Li‐Bo , Jiang Wen‐Guo , Chen Jin‐Jin , Xu Qiang , Lv Chen‐Long , Jiang Bao‐Gui , Kou Zeng‐Qiang , Wang Guo‐Lin , Fang Li‐Qun 
Published: May 2024

AbstractAfter the termination of zero‐COVID‐19 policy, the populace in China has experienced both Omicron BA.5 and XBB waves. Considering the poor antibody responses and severe outcomes observed among the elderly following infection, we conducted a longitudinal investigation to examine the epidemiological characteristics and antibody kinetics among 107 boosted elderly participants following the Omicron BA.5 and XBB waves. We observed that 96 participants (89.7%) were infected with Omicron BA.5, while 59 (55.1%) participants were infected with Omicron XBB. Notably, 52 participants (48.6%) experienced dual infections of both Omicron BA.5 and XBB. The proportion of symptomatic cases appeared to decrease following the XBB wave (18.6%) compared to that after the BA.5 wave (59.3%). Omicron BA.5 breakthrough infection induced lower neutralizing antibody titers against XBB.1.5, BA.2.86, and JN.1, while reinfection with Omicron XBB broadened the antibody responses against all measured Omicron subvariants and may alleviate the wild type‐vaccination induced immune imprinting. Boosted vaccination type and comorbidities were the significant factors associated with antibody responses. Updated vaccines based on emerging severe acute respiratory syndrome coronavirus 2 variants are needed to control the Coronavirus Disease 2019 pandemic in the elderly.
Utilization and perspectives of weight loss medications in pediatric metabolic dysfunction‐associated steatotic liver disease
Authors: Kehar Mohit , Ibrahim Samar H. , Ramirez Charina M. , Amin Saista Asif , Diamond Tamir , Mohammad Saeed 
Published: May 2024

AbstractMetabolic dysfunction‐associated steatotic liver disease (MASLD) is increasing globally in pediatric populations. Currently, MASLD management primarily relies on lifestyle interventions, which pose challenges in sustaining long‐term weight loss. This study investigated the use of weight loss medications in MASLD care through an international survey of 166 pediatric gastroenterologists and hepatologists. The results indicated a notable interest in weight loss medications, with 38% of practitioners considering or using them, particularly glucagon‐like peptide‐1 receptor agonists. However, the survey also revealed a tendency among clinicians to refer patients to specialists, emphasizing the potential gap between acknowledgment and prescription practices. Challenges include the lack of guidelines and uncertainty regarding side effects. The study highlights a pressing need for education, with over 90% of the respondents expressing an interest. Our study highlights the current management of MASLD, the potential role of pharmacotherapy, and highlights avenues for improved care and education in this dynamic field.
Geometric distortion on video see‐through head‐mounted displays
Authors: Zhao Chumin , Beams Ryan 
Published: May 2024

AbstractVideo see‐through (VST) head‐mounted displays (HMDs) reconstruct the physical world using outward‐facing cameras and depth sensors. One of the major challenges for VST HMDs is the geometric distortion of the physical pass‐through content. In this study, we present the experimental setup and metrology for VST geometric distortion measurement on single‐camera and dual‐camera VST HMDs. The VST geometric distortion is compared to the digital distortion by the HMD. Finally, we investigate the impacts of camera misalignment and depth distance on VST geometric distortion without and with angular‐based distortion correction. The results demonstrate that camera misalignment with respect to the eye position is the primary root cause for the distortion. Dual‐camera setup is necessary to minimize the VST geometric distortion by placing the cameras close to the eye positions. Although distortion correction can partially mitigate VST geometric distortion in a 2D plane, it remains a challenge for VST distortion correction at multiple depth distance in the 3D space. The method and findings presented of this study may provide guidelines for evaluation of spatial accuracy on VST HMDs and hardware design.
Qualitative and quantitative changes in phenology of chlorophyll a concentrations during the transition from eutrophy to oligotrophy
Authors: Straile Dietmar , Rothhaupt Karl‐Otto 
Published: May 2024

AbstractThe PEG (Plankton Ecology Group) model predicts differences in phenology between eutrophic and oligotrophic lakes regarding the occurrence, timing and magnitude of annual chlorophyll maxima and minima. While these predictions have been tested between lakes, hardly any tests exist using long‐term data. We test these predictions using chlorophyll time‐series (1980–2019) from Lake Constance in which trophic status shifted from eutrophic to oligotrophic conditions. We show that oligotrophication subsequently resulted in reduction of the summer and spring blooms, and finally the loss of the clear‐water phase. In contrast to the PEG model the spring bloom was not delayed, but advanced with oligotrophication. Warming modified the seasonal patterns via advancing clear‐water timing. Oligotrophication did not only influence phenologies, but also the importance of independent variables driving phenologies. Thus, the decline of nutrients was the dominant factor in shaping the seasonal patterns of chlorophyll in Lake Constance during the last four decades.
Light‐adaptive Mimicking Retina with In Situ Image Memorization via Resistive Switching Photomemristor Arrays
Authors: Hu Zijun , Hu Ying , Su Li , Fang Xiaosheng 
Published: May 2024

AbstractArtificial visual memory systems have been of particular interest since the development of machine vision and bionic robots. Ordinarily, the conventional system architecture requires the complex integration of two functional modules, a photo‐sensor and a memory device, which greatly limits the operating efficiency and increases the extra energy consumption. Nonetheless, other simply configured optoelectronics memory devices generally face challenges of adaption in complex light environments. Here, a resistive switching (RS) perovskite‐based photomemristor is presented that mimics the retina function. The dual function of light perception and in situ storage are both achieved. In the dark condition, it exhibits impressive memory performance with a high ON/OFF ratio of 104, a long retention time of over 104 s, and a low operating voltage of 0.38 V. With illumination, it shows self‐powered, broadband photo‐detecting characteristics with responsivity of 70 mA W−1 and detectivity of 7.5 × 1010 Jones. More importantly, benefiting from the material dual‐phase configuration, the highly steady photo‐adjusted RS windows are achieved. Its light‐adaptive memory application in dynamic environments is further demonstrated using the mimicking retina for a machine eye. This work can provide a strategy for enhanced RS photomemristor and its application in changing and varied scenarios.
Electronically Controlled Dual‐Wavelength Switchable SRS Fiber Amplifier in the NIR‐II Region for Multispectral Photoacoustic Microscopy
Authors: Lee Hwidon , Seeger Markus R. , Bouma Brett E. 
Published: May 2024

AbstractPhotoacoustic microscopy (PAM) is a high‐resolution and non‐invasive imaging modality that provides optical absorption contrast. By employing dual‐ or multiple‐wavelength excitation, PAM extends its capabilities to offer valuable spectroscopic information. To achieve efficient multispectral PAM imaging, an essential requirement is a light source characterized by a high repetition rate and switching rate, a ≈microjoule pulse energy, and a ≈nanosecond pulse duration. However, there exists a notable deficiency in suitable light sources, particularly in the near‐infrared‐II window. In this study, a custom‐built all‐fiber‐based light source is reported that provides >3 µJ, 2 ns pulses with a repetition rate of 200 kHz. Digitally addressed semiconductor seed lasers, followed by stimulated Raman scattering amplification, enabled arbitrary sequences of pulses having wavelengths of either 1168.4 or 1202.1 nm. In a switching mode of operation, a 100 kHz switching rate is used to alternate between these wavelengths in even/odd pulses. Furthermore, a high‐resolution multispectral photoacoustic microscopy of three polymer samples is demonstrated with the proposed light source.
Multimode Emission in GaN Microdisk Lasers
Authors: Drechsler Monty L. , Choi Luca Sung‐Min , Tabataba‐Vakili Farsane , Nippert Felix , Koulas‐Simos Aris , Lorke Michael , Reitzenstein Stephan , Alloing Blandine , Boucaud Philippe , Wagner Markus R. , Jahnke Frank 
Published: May 2024

AbstractQuantum well nanolasers usually show single‐mode lasing, as gain saturation suppresses emissions in other modes. In contrast, for whispering gallery mode microdisk lasers with GaN quantum wells as active material, above threshold multimode laser emission is observed. This intriguing emission feature is manifested in the fact that several modes simultaneously show the characteristic kink in the input–output curve at the onset of lasing. A quantum theory for nanolasers is used to support the experimental finding and to analyze this behavior in the presence of gain saturation. Coupling effects between neighboring modes are identified as the origin of multimode lasing, which initiate photon exchange between modes via population pulsations similar to classical wave‐mixing effects. A reduction of this type of mode coupling with increasing mode spacing is demonstrated. The results can pave the way for multimode application of nanolasers in integrated photonic circuits.
Simultaneous NIR Emission and Thermal Stability Enhancement in Garnet‐Type NIR Phosphors through the Synergistic Effect of Lattice Distortion and Enhanced Rigidity
Authors: Wang Yining , Xu Zheng , Shang Mengmeng , Sun Yixin , Xing Xiaole , Dang Peipei , Lin Jun 
Published: May 2024

AbstractEven though there have been significant advancements in the development of Cr3+‐activated near‐infrared (NIR) phosphors, the challenge still remains to develop highly efficient and thermally stable NIR phosphors. Here, the Ca4‐xZnxHfGe3O12:0.03Cr3+ solid solution phosphors with 834–806 nm NIR emission are constructed by substituting Zn2+ for Ca2+, thereby facilitating the formation of [ZnO6] luminescence site. The coexistence of [HfO6] and [Zn/CaO6] luminescence centers is confirmed through DFT calculation, time‐resolved photoluminescence (TRPL) spectroscopy, and low‐temperature‐photoluminescence (77 K) spectroscopy. The formation of [ZnO6] effectively resolves the issue of lattice mismatch between Cr3+ and Ca2+. Furthermore, the simultaneous enhancement of luminescence intensity and thermal stability is realized through a synergistic combination of lattice distortion and rigidity enhancement. By optimizing the substitution concentration of Cr3+, the internal quantum efficiency (IQE) of 92% and an external quantum efficiency (EQE) of 29% are finally achieved. Meanwhile, the thermal stability is also enhanced from 59%@400 K (x = 0) to 81%@400 K (x = 0.8). The developed NIR phosphor‐converted light‐emitting diodes (pc‐LEDs) exhibit promising prospects in the fields of security, biomedicine, non‐destructive testing and rapid identification.
The grade of obesity affects the noninvasive diagnosis of advanced fibrosis in individuals with MASLD
Authors: Chouik Yasmina , Aubin Adrien , Maynard‐Muet Marianne , Segrestin Bérénice , Milot Laurent , Hervieu Valérie , Zoulim Fabien , Disse Emmanuel , Levrero Massimo , Caussy Cyrielle 
Published: May 2024

AbstractObjectiveMetabolic dysfunction‐associated steatotic liver disease (MASLD) is closely associated with obesity. We aimed to assess the impact of obesity on the performance of different noninvasive tests, including liver stiffness measurement (LSM) and Agile3+ (A3+), to detect advanced fibrosis (AF) in a population of patients with MASLD encompassing a wide range of BMI values.MethodsA total of 479 patients with MASLD were consecutively included (Lyon Hepatology Institute). Clinical data and noninvasive tests, including FibroTest, LSM, A3+, Fibrosis‐4 (FIB‐4), magnetic resonance elastography, and liver biopsies, were collected. AF was determined by a composite endpoint, i.e., histological stage ≥ F3, overt diagnosis of cirrhosis by magnetic resonance elastography, or concordant LSM ≥ 9.6 kPa and FibroTest ≥ F3.ResultsThe median BMI was 35.0 kg/m2, and the prevalence of AF was 28.6%. Patients with BMI ≥ 35 versus <35 had a lower proportion of AF, i.e., 19.3% versus 38.1% (p < 0.001), but higher indeterminate status for AF (34.2% vs. 15.4%; p < 0.001). In the case of BMI ≥ 35, LSM had lower specificity to rule in AF (77.9%) versus A3+ (90.4%), but A3+ had decreased sensitivity to rule out AF. A sequential LSM/A3+ strategy achieved high specificity to rule in AF and lowered the proportion of indeterminate cases in patients with BMI ≥ 35.ConclusionsThe grade of obesity affects the detection of MASLD‐related AF. A sequential use of LSM/A3+ could improve AF detection in patients with BMI ≥ 35.
Matrix‐phase material selection for shape memory polymer composites: A comparative analysis of multi‐criteria decision‐making
Authors: Omosa Geoffrey Barongo , Mwema F. M. , Akinlabi Esther T. , Jen T. C. , Mutua J. M. 
Published: May 2024

AbstractIn the present study, the selection of suitable shape memory polymers (SMPs) to be used as the matrix‐phase material with various (In)organic filler materials to achieve the required optimum multi‐stimuli response in shape memory polymer composites (SMPC) systems is analyzed. The selection of these materials is based on their mechanical and physical properties as well as other underlying factors such as cost, availability, shape recovery rate, and aesthetic characteristics. In this study, the entropy method was applied to estimate the weightages of the various criteria while the gray relation analysis (GRA) and the technique for order preference by similarity to ideal solution (TOPSIS). Multi‐criteria decision‐making (MCDM) approaches have been used to rank the suitable matrix‐phase polymer materials for manufacturing shape memory polymer composites (SMPC) system. A total of eight alternative SMP matrix‐phase materials based on a set of nine criteria were analyzed and ranked. The proposed methodology and the result obtained thereof have been illustrated in detail. The results obtained from TOPSIS and GRA methods have been compared to conclude the effects of the material properties on the ranking and the selection of the SMP materials. Among all the eight alternatives considered, thermoplastic polyurethane (TPU) was found to be the best material in both the MCDM methods. The material cost, resistivity, % elongation, and hydrophobicity present the most influencing properties on the SMP material selection, whereas density presents no effect on the SMP matrix material selection. The robustness of the results for the comparative analysis was verified using TOPSIS methodology to validate its reliability. It was revealed that the TPU, polycarbonate, polypropylene, and epoxy‐resin/poly(lactic acid) are the most dominant matrix‐phase SMP material alternatives when a deviation in the entropy weights of the primary evaluation criteria is applied. The novelty of this study is the exploration and application of statistical MCDM methods of engineering material selection problems based on a set of decision criteria, which can be time‐consuming and costly while using experimental analysis methods.Highlights
SMPCs are applicable engineering materials thus making their research viable.
SMPC systems can undergo various shape changes under external stimuli.
Selection of matrix‐phase polymer is critical in achieving desired objectives.
GRA and TOPSIS MCDM approaches have been applied in the selection process.
TPU was found as the best material in both methods.