bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between hyperuricemia and chronic total coronary occlusion in non–chronic kidney disease populations: a cross-sectional study
Authors: Wang Jianping , Chen Xiaoli , He Zhongwei , Xiao Lian , Xiao Kaiyong , Zhao Lin , Yu Qiang , Hou Yulin , Li Qingrui , He Lei , Feng Hui , Luo Xiaowen 
Published: June 2024

Background
Chronic total coronary occlusion (CTO) is an extremely hazardous condition that leads to various clinical phenomena and complications and results in social and economic burdens. Hyperuricemia (HU) is often associated with atherosclerosis. Few studies, however, have investigated the risk of CTO in individuals with HU and the role of traditional cardiovascular risk factors in this setting.

Methods
A cohort of 1245 individuals without chronic kidney disease from southwest China who underwent coronary angiography between February 2018 and June 2021 were enrolled. CTO was defined as a total occlusion of any coronary artery or arteries for more than 3 months. HU was defined as a serum uric acid level of ≥420 µmol/L in men and ≥360 µmol/L in women. Univariate and multivariate logistic regression models and subgroup analyses were applied to assess the relationship between HU and CTO.

Results
After adjustment, HU was noted to be associated with a 1.47-fold increase in the risk of CTO [odds ratio (OR), 1.47; 95% confidence interval (CI), 1.06–2.58; P = 0.026]. As a continuous variable, uric acid was an independent predictor of CTO (OR, 1.002; 95% CI, 1.001–1.004; P = 0.047). Subgroup analyses showed that the risk of CTO was higher among individuals under 65 years of age (OR, 2.77; 95% CI, 1.3–5.89), nonobese individuals (OR, 1.9; 95% CI, 1.16–3.1), and those with dyslipidemia (OR, 1.8; 95% CI, 1.04–3.11), while sex, smoking, hypertension, and diabetes did not show similar effects. Interaction analyses revealed no interaction among subgroups.

Conclusion
Among individuals residing in southwest China, HU was associated with an increased risk of CTO in non-CKD individuals, especially those under 65 years of age and nonobese and dyslipidemic individuals.
Deficiency of adenosine deaminase 2 (DADA2) with bilateral renal subcapsular hematoma: a case report and literature review
Authors: Tuqan Anas R. , Barabrah Anas M. , Zaben Basel A. , Shehadeh Mohammad Hakam , Adas Motaz M. 
Published: June 2024

Introduction and importance:
Deficiency of adenosine deaminase 2 (DADA2) is a rare autosomal recessive genetic disorder caused by loss-of-function mutations in the adenosine deaminase 2 (ADA2) gene. This condition primarily manifests in pediatric cases before the age of 10 years, with sporadic cases reported in adults. ADA2 is a critical enzyme involved in macrophage differentiation and immune homeostasis. The clinical manifestations of DADA2 vary widely and can affect multiple organ systems. Our case uniquely highlights an infrequent DADA2 manifestation.

Case presentation:
An 18-year-old female presented with right flank pain, fever, and a history of joint pain, Raynaud’s phenomenon, livedo-like rash, and chronic abdominal pain. Physical examination revealed subcapsular hematoma in the right kidney. Further evaluation showed positive serologic tests for rheumatoid factor and antinuclear antibody (ANA). Genetic testing confirmed DADA2 homozygosity. The patient was discharged on the appropriate medications.

Clinical discussion:
DADA2 is associated with vascular dysfunction and systemic vasculopathy. The clinical manifestations of DADA2 encompass a spectrum of organ involvement, including the skin, nervous system, gastrointestinal system, renal system, and the cardiovascular system. Early recognition and diagnosis are crucial for appropriate management.

Conclusion:
This case report highlights the diverse clinical presentations of ADA2 deficiency, specifically focusing on bilateral renal subcapsular hematoma. This finding emphasizes the importance of considering DADA2 as a differential diagnosis in patients presenting with unexplained renal manifestations. Increased awareness of the varied clinical presentations of DADA2 will contribute to earlier diagnosis, appropriate management, and improved outcomes in patients affected by this rare genetic disorder.
Development and validation of the air pollution exposure protective behavior scale for toddlers
Authors: Wang Chongkun , Shen Meidi , Hu Yinchu , Li Ruiqiong , Dorj Gantuya , Gombojav Enkhjargal , Shi Yuexian , Ren Lihua 
Published: June 2024

Abstract

Objectives:
This study aimed to develop the Air Pollution Exposure Protective Behavior Scale for Toddlers (APP-T) and test its psychometric properties, to provide a tool for the assessment of air pollution exposure protective behaviors for toddlers.

Methods:
A draft scale containing 39 items was constructed based on an evidence summary, an interview and literature review. The scale was revised according to the comments from 16 experts in public health, environmental science and nursing through a modified Delphi method, and the results of a pilot test of air pollution exposure protective behaviors for toddlers (n=57). A formal survey was conducted using the revised scale (n=876). Factor structure and model fit of the scale were examined using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). An expert consultation was conducted to assess the content validity. Known-groups validity, internal consistency, test-retest reliability, and split-half reliability of the scale were also calculated.

Results:
A five-point Likert scale of four dimensions, consisting of 25 main items, two additional items and four validation items, was developed in this study, to assess the air pollution exposure protective behaviors for toddlers. In the formal survey, the four factors of the scale explained 63.0% of the variance, with a good model fit and acceptable convergence. The scale Cronbach’s α was 0.93. The test-retest correlation coefficients for all four dimensions and the whole scale scores were above 0.70 and statistically significant, with a Spearman-Brown coefficient of 0.85.

Conclusion:
This study developed and validated an assessment scale, the Air Pollution Exposure Protective Behavior Scale for Toddlers (APP-T), with good reliability and validity. This scale can provide a basis for clarifying the current situation of air pollution exposure protective behaviors for toddlers and for implementing precision nursing on respiratory symptoms and diseases for toddlers.
Digital twin prevalence in the medical caring fields: a bibliomatrics study and visualization analysis via CiteSpace
Authors: Zhou Ting Ting , Gong Ping , Tian Yin Ying , Su Meng Ting , Chen Xing Yang 
Published: June 2024

Abstract

Objectives:
We conducted academic research utilizing the visualization tool CiteSpace to explore the direct relationship between digital twin technology and medical care.

Methods:
We collected data from the Web Of Science Core Collection, PubMed ScienceDirect, SpringerLink, Wiley Online Library databases from 2010-2023, displayed visualization analysis of countries, institutions, and co-occurring keywords, cluster, citation bursts and timeline, also calculated nodes, edges, centrality, modularity and silhouette via CiteSpace 5.75r version.

Results:
The data incorporated 1109 studies, graphed the yearly publication number from 2010-2023, showed a steady increase trend. The tree map displayed the top ten prominent study subjects, the first one was “Health Care Science Service”. The top three of Countries were USA, Germany and England, and the top one institution was Harvard Medical School. As for the top five keywords were “digital health”, “care”, “technology”, “digital twin”, and “telemedicine”. The rank three cluster were “Digital Health Applications”, “Digital Twin”, and “Machine Learning”. We also displayed the visualization analysis of citation bursts and timeline.

Conclusions:
Digital twins has welcomed a popular development in strong countries and top-tier institutions, and has a tight connection with mobile health and artificial intelligence. It has been widely used in clinical trials, like surgical operation and rehabilitation discipline, to predict patient treatment outcome, and estimate potential complications, we should facilitate digital twins in clinical practice conversion and application, and try to tackle the problems from privacy concern and economy challenge.
Sexually Transmitted Infection and HIV Testing and Diagnosis Among 15- to 44-Year-Old Patients With and Without Opioid Use Disorder
Authors: Patel Chirag G. , DePadilla Lara , Cuffe Kendra M. , Tao Guoyu , Gift Thomas 
Published: June 2024

Background
The association between illicit opioid use and prescription opioid misuse and sexually transmitted infections (STIs) has not been examined recently. Our study aimed to explore differences in STI/HIV care, and delivery of recommended testing and diagnoses among patients with and without opioid use disorder (OUD).

Methods
Using 2019 MarketScan commercial claims data, we identified 15- to 44-year-old male and female patients, to assess the percentages of STI/HIV diagnoses (using International Classification of Diseases, Tenth Revision, Clinical Modification) and screening (using Current Procedure Terminology codes) among patients with or without OUD diagnoses codes. We further assessed STI/HIV testing and diagnoses by demographic factors.

Results
We identified 24,724 patients with OUD codes among 7.31 million patients. Both STI/HIV testing and diagnoses were significantly (P < 0.05) higher among patients with OUD codes versus without: testing percentages were 16.81% versus 12.93% for chlamydia, 22.31% versus 16.62% for gonorrhea, 15.26% versus 7.61% for syphilis, and 18.18% versus 7.60% for HIV; diagnoses were 0.80% versus 0.35% for chlamydia, 0.30% versus 0.11% for gonorrhea, 0.23% versus 0.07% for syphilis, and 0.74% versus 0.33% for HIV. Similarly, among 0.53 million 15- to 24-year-old females who received services suggestive of sexual activity, chlamydia testing was significantly (P < 0.05) higher among patients with OUD codes versus without (59.78% vs. 55.66%).

Conclusions
Patients with OUD codes have higher percentages of STI/HIV testing and diagnoses codes compared with those without OUD codes. Clinicians may want to consider a comprehensive multidisciplinary (OUD and STI prevention) approach in patient care and provide recommended STI/HIV screening among patients with OUD if not performed.
Prediction of Interactomic HUB Genes in Periodontitis With Acute Myocardial Infarction
Authors: Thilagar Sri Sivashankari , Yadalam Pradeep Kumar , Ronsivalle Vincenzo , Cicciù Marco , Minervini Giuseppe 
Published: June 2024

Background:
Acute myocardial infarction (AMI) risk correlates with C-reactive protein (CRP) levels, suggesting systemic inflammation is present well before AMI. Studying different types of periodontal disease (PD), extremely common in individuals at risk for AMI, has been one important research topic. According to recent research, AMI and PD interact via the systemic production of certain proinflammatory and anti-inflammatory cytokines, small signal molecules, and enzymes that control the onset and development of both disorders’ chronic inflammatory reactions. This study uses machine learning to identify the interactome hub biomarker genes in acute myocardial infarction and periodontitis.

Methods:

GSE208194 and GSE222883 were chosen for our research after a thorough search using keywords related to the study’s goal from the gene expression omnibus (GEO) datasets. DEGs were identified from the GEOR tool, and the hub gene was identified using Cytoscape-cytohubba. Using expression values, Random Forest, Adaptive Boosting, and Naive Bayes, widgets-generated transcriptomics data, were labelled, and divided into 80/20 training and testing data with cross-validation. ROC curve, confusion matrix, and AUC were determined. In addition, Functional Enrichment Analysis of Differentially Expressed Gene analysis was performed.

Results:
Random Forest, AdaBoost, and Naive Bayes models with 99%, 100%, and 75% AUC, respectively. Compared to RF, AdaBoost, and NB classification models, AdaBoost had the highest AUC. Categorization algorithms may be better predictors than important biomarkers.

Conclusions:
Machine learning model predicts hub and non-hub genes from genomic datasets with periodontitis and acute myocardial infarction.
Comparison Between an Expert Operator an Inexperienced Operator, and Artificial Intelligence Software: A Brief Clinical Study of Cephalometric Diagnostic
Authors: Muñoz Gonzalo , Zamora Daniel , Brito Leonardo , Ravelo Victor , de Moraes Marcio , Olate Sergio 
Published: June 2024

Introduction:
Artificial intelligence (AI) is constantly developing in several medical areas and has become useful to assist with treatment planning. Orthodontics and maxillofacial surgery use AI-based technology to identify and select cephalometric points for diagnostics. Although some studies have shown promising results from the use of AI, the evidence is still limited. Hence, additional investigation is justified.

Materials and Methods:
In this retrospective study, 2 human operators (1 expert and 1 inexperienced) and 1 software analyzed 30 lateral cephalograms of individuals with orthodontic treatment indications. They measured 10 cephalometric variables and then 2 weeks later, repeated measurements on 30% of the sample. We evaluated the reliability of the measurements between the 2-time points and the differences in the means between the expert operator and the AI software and between the expert and inexperienced operators.

Results:
There was high reliability for the expert operator and AI measurements, and moderate reliability for the inexperienced operator measurements. There were some significant differences in the means produced by the AI software and the inexperienced operator compared with the expert operator.

Conclusion:
Although AI is useful for cephalometric analysis, it should be used with caution because there are differences compared with analysis by humans.
Assessment Methods and Intervention Strategies for Cleft-Related Lateral Misarticulation in Chinese-Speaking Children
Authors: Zhang Susu , Wang Tingting , Tang Lihua , Li Xiao , Shang Zibo , Zhou Tianyi , Lan Na , Yang Lijun , Zhou Haiyan 
Published: June 2024

The aim of this study was to analyze the characteristics and error speech features of cleft-related lateral misarticulation and provide a basis for clinical evaluation and rational intervention. Participants who were diagnosed with lateral misarticulation after cleft palate repairment were 126 children aged 4, 6 to 16, and 11, and they had complete palatopharyngeal closure, no abnormalities in their speech organs and occlusion, and no hearing or intellectual impairments. The Chinese standard pronunciation clarity word list, the American KAY CSL4500, the Beijing Yangchen YF-16 computer speech analysis workstation, soundproof rooms, Wechsler scales of intelligence—fourth edition, and audiometers were used to evaluate the cleft-related lateral misarticulation. Statistical analysis was performed on the age, gender, error rate, corner of the mouth deviation direction, comorbidity, duration of intervention, period of treatment, and therapeutic effect of concentrated or normal intervention group in different patients. Our results showed that 2 to 3 straight stripes were visible at the onset of consonants /ti:/ /tʻi:/, and 3 clear straight lines were visible in /tʂ/, indicating that the lateralized sound had 2 or 3 bursts and lasted for 1 to 2 ms. The onset age of lateralized sound was mostly below 12 years old. Chinese lateralized sound mainly occurred in vowel /i:/, and the occurrence rate of consonants with tongue surface /tɕ]/ /tɕʻ/ /ɕ/ was the highest. In addition, the corner of the mouth deviation was also an indicator of lateralization sound, and other types of speech disorders mostly accompanied it. There was a significant difference in the improvement of speech clarity between the concentrated intervention group and the normal group before and after treatment. The 2 groups’ average duration and course of treatment were not significantly different. Still, the period of concentrated intervention was shortened considerably, and the speech clarity of both groups of children after treatment exceeded 96%, reaching a normal level.
Primary Robotic Versus Conventional Laparoscopic Roux-en-Y Gastric Bypass in Morbidly Obese Patients: A Systematic Review and Meta-Analysis
Authors: Du Xiaoyu , Shen Liwen , Xu Shumei , Xu Wei , Yang Jiaxing , Liu Yichen , Li Kun , Fan Ruifang , Yan Long 
Published: June 2024

Background:
Robotic Roux-en-Y gastric bypass (RRYGB) and conventional laparoscopic Roux-en-Y gastric bypass (LRYGB) are commonly performed as primary bariatric procedures. The aim of this article was to assess the role of RRYGB in patients undergoing primary bariatric procedures.

Methods:
All of the qualified studies were selected from the PubMed, Embase, and Web of Science databases, etc. We mainly compared the outcomes and safety between RRYGB and LRYGB. The outcomes evaluation included surgical effect and surgical safety.

Result:
In total, 35 studies containing 426,463 patients were selected. The mortalities of patients adopting these 2 bariatric procedures were similar (RRYGB: 59/28,023, 0.21%; LRYGB: 612/397,945, 0.15%). We found no significant difference between RRYGB and LRYGB in the incidence of postoperative complications (30-day: OR=1.06, P=0.18; 1-y: OR=1.06, P=0.92). The incidence of 30-day readmission after the operation was higher in RRYGB patients (OR=1.24, P=0.003). However, we found that the RRYGB group had a lower incidence of anastomotic stricture 1 year after the operation when compared with LRYGB (OR=0.35, P=0.0004). The 1-year %EBMIL of these 2 groups was similar (78.53% vs. 76.02%). There was no significant difference in length of hospital stay (LOS) (WMD=−0.03d, P=0.59), conversion rate (OR=0.84, P=0.75), or anastomotic leak (OR=1.00, P=0.99) between these 2 groups. The mean hospital charges were higher in the RRYGB group ($11234.75 vs. $9468.58).

Conclusion:
This systematic review and meta-analysis showed no significant advantage of RRYGB in surgical effect or reduction of intraoperative complications. RRYGB may reduce the incidence of some postoperative long-term complications. The mean hospital charges of RRYGB were higher.
Connectome-based prediction of cognitive performance in patients with temporal lobe epilepsy
Authors: Qin Lu , Pan Liya , Chen Zirong , Zhou Qin , Zhou Xia , Zheng Jinou 
Published: June 2024

Objective
Temporal lobe epilepsy (TLE) patients often exhibit varying degrees of cognitive impairments. This study aims to predict cognitive performance in TLE patients by applying a connectome-based predictive model (CPM) to whole-brain resting-state functional connectivity (RSFC) data.

Methods
A CPM was established and leave-one-out cross-validation was employed to decode the cognitive performance of patients with TLE based on the whole-brain RSFC.

Results
Our findings indicate that cognitive performance in TLE can be predicted through the internal and network connections of the parietal lobe, limbic lobe, and cerebellum systems. These systems play crucial roles in cognitive control, emotion processing, and social perception and communication, respectively. In the subgroup analysis, CPM successfully predicted TLE patients with and without focal to bilateral tonic–clonic seizures (FBCTS). Additionally, significant differences were noted between the two TLE patient groups and the normal control group.

Conclusion
This data-driven approach provides evidence for the potential of predicting brain features based on the inherent resting-state brain network organization. Our study offers an initial step towards an individualized prediction of cognitive performance in TLE patients, which may be beneficial for diagnosis, prognosis, and treatment planning.
Atrial Fibrillation Following Electroconvulsive Therapy
Authors: Baroni Mariana , Albaba Dania , Ngo Alexandra , Livingston Robin K. 
Published: June 2024

Abstract
Electroconvulsive therapy (ECT) is considered the gold standard treatment for many psychiatric illnesses; however, it is not without risk. There have been no systematic reviews to date on new-onset atrial fibrillation following ECT. Thus, the aim of this study is to identify reported occurrences of new-onset atrial fibrillation following ECT and the ability to safely resume ECT thereafter.
A case pertaining to the development of atrial fibrillation after ECT in a young healthy male is presented. In addition, a systematic review of the literature pertaining to atrial fibrillation after ECT was conducted through PubMed, PsycInfo, and EMBASE. Of the 233 articles screened, 15 articles were selected for in-depth review. Of the 15 articles, only 10 articles met inclusion criteria. These articles included 9 case reports and 1 retrospective review. The retrospective review included 1 patient that developed atrial fibrillation out of 13 patients receiving ECT at the site. The 10 patients included varied in age, risk factors, type of ECT conducted, and treatment of the atrial fibrillation. Of the 4 articles that discussed outcomes, all patients were able to return to ECT without further complications.
There are many potential reasons ECT may induce atrial fibrillation, and there are additional treatment considerations for atrial fibrillation in patients receiving ECT. Notably, our results indicate that many have been able to continue ECT without further complications; however, more research is needed to identify the frequency of this adverse reaction.