bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Aspects of the Efficacy and Safety Profile of Medicines Containing Omega-3-Acids Ethyl Esters
Authors: Гринько Д.В. , Кучко А.М. , Ефремова И.Н. , Федосеева И.И. 
Published: May 2024

При применении лекарственных препаратов, содержащих омега-3 кислот этиловые эфиры, по показанию «профилактика рецидивов сердечно-сосудистых заболеваний» у пациентов, перенесших инфаркт миокарда, соотношение польза – риск в настоящее время оценивается как неблагоприятное. Совокупность результатов клинических исследований и метаанализов не подтверждает терапевтическую эффективность омега-3 кислоты этиловых эфиров во вторичной профилактике сердечно-сосудистых заболеваний после инфаркта миокарда, в том числе у пациентов из группы высокого риска. Для вышеуказанных лекарственных препаратов сохраняется показание к применению – лечение гипертриглицеридемии, когда изменения питания и образа жизни недостаточно для снижения уровня триглицеридов крови. Установлена как минимум возможная причинно-следственная взаимосвязь между применением омега-3 кислоты этиловых эфиров и развитием фибрилляции предсердий, данная нежелательная реакция оценивается как частая.
Using the medicinal product (s) containing omega-3-acids ethyl esters, according to the indication "prevention of recurrence of cardiovascular diseases" in patients who have suffered a myocardial infarction, the benefit-risk ratio is currently assessed as unfavorable. The totality of the results of clinical studies and meta-analyses does not confirm the therapeutic efficacy of omega-3-acid ethyl esters in the secondary prevention of cardiovascular diseases after myocardial infarction, including in high-risk patients. For the above-mentioned drugs, the indication for use remains – the treatment of hypertriglyceridemia, when changes in diet and lifestyle are not enough to reduce blood triglyceride levels. At least a possible causal relationship has been established between the use of omega-3-acid ethyl esters and the development of atrial fibrillation, this adverse reaction is assessed as frequent.
ALTERAÇÕES FONOAUDIOLÓGICAS NA DEGLUTIÇÃO DE PACIENTES COM CÂNCER DE CABEÇA E PESCOÇO
Authors: Dutra Milena Silva , Junior Juarez Belmiro Moraes 
Published: May 2024

O câncer de cabeça e pescoço (CCP) é o termo utilizado para descrever doenças malignas que afetam as vias aerodigestivas superiores. A patologia pode resultar em diversas sequelas nos pacientes, afetando aspectos físicos, nutricionais, de fonação e respiração. A disfagia, um distúrbio de deglutição, é comum nesses pacientes e caracteriza-se por alterações em qualquer fase ou entre as fases da dinâmica de deglutição. Objetivo: Elucidar as principais alterações fonoaudiológicas em pacientes com câncer de cabeça e pescoço. Metodologia: Trata-se de uma revisão sistemática da literatura, na qual a pergunta norteadora é: Quais as alterações fonoaudiológicas na deglutição de pacientes com câncer de cabeça e pescoço? O período da realização do estudo abrangeu os meses de fevereiro a abril de 2024. Resultados: Evidenciou-se que os pacientes com CCP, majoritariamente, são do sexo masculino, sendo o que mais prevaleceu constando em 90% dos estudos, com idade média entre 50 a 69 anos. Quanto ao tipo de tumor primário, observou-se maior representatividade na cavidade oral 33,33%, orofaringe 28,57%, laringe 19,04%, faringe e tireóidea com 9,52% respectivamente. Conclusão: conclui-se que a gravidade e sintomas da disfagia dependem do local e extensão da lesão.
Dekonstruksi terhadap Pemikiran Nur Holis Madjid “Islam Yes, Partai Islam No “: Upaya Menjawab Realitas Partai Islam Indonesia pada Pemilu 2024
Authors: Nata Yolies Yongky 
Published: May 2024

Dekonstruksi Terhadap Pemikiran Nur Holis Madjid “Islam Yes, Partai Islam No “ : Upaya Menjawab Realitas Partai Islam Indonesia Pada Pemilu 2024 ini merupakan analisis terhadap sebuah Slogan Pemikiran seorang cendikiawan muslim Nur Holis Madjid yang di cetuskan pada era 1970 di taman mini Ismail Marzuki Jakarta yang isinya mengklasifikasikan dan mengkritisi tentang Islam dan Partai Islam, Slogan Tersebut menggemparkan jagat indonesia karena terhadap pro dan kontra terhadap slogan pemikiran tersebut, seiring dengan perkembangan kekinian dengan melihat realitas yang ada bahwa partai islam kini semakin hari semakin tidak dapat menyaingi partai nasionalis, maka dengan Pendekatan Konsep akan dapat menganalisa terhadap pemikiran Nur Holis Majid dengan keadaan kekinian tentang partai islam, sehingga dengan pendekatan Konsepn terhadap pemikiran nur holis majid dapat menjawab kenapa partai islam semakin hari semakin tertinggal dan dengan menggunakan pendekatan konsep dapat menganalisa relevansi pemikiran nur holis majid terhadap situasi partai politik islam kekinian yang semakin tidak mendapatkan kepercayaan dari masyarakat islam sendiri.
Percepción y Cuidado del Recurso Hídrico como Estrategia Pedagógica para Fortalecer el Currículo de la Institución Educativa de Puerto López-Pinillos
Authors: Recuero Pacheco Harold Miguel , Tovar Rúa Diana Cecilia 
Published: May 2024

Los recursos hídricos son de gran importancia para la vida en todos los ecosistemas, e imprescindible para el desarrollo de la agricultura e industria de un país por tanto, su escasez o abundancia determinan el potencial productivo de una región, jugando un papel fundamental en la conformación de comunidades y desarrollo de una sociedad. En el corregimiento Puerto Lopéz del municipio de Pinillos, se ha evidenciado una percepción baja sobre la importancia de proteger y aprovechar de forma sostenible estos recursos, lo cual impide en muchos casos lograr avances en la protección de los mismos en beneficio de la comunidad. Por tal razón, se propuso la implementación de estrategias didactico-ambiental con enfoque cualitativo para generar el desarrollo de herramientas accesibles para estudiantes y docentes de la Institución Educativa de Puerto Lòpez y fomentar así el interés en el aprendizaje de estrategías pedagogicas orientadas a la enseñanza de las ciencias naturales y educación ambiental. Los resultados arrojaron poco conocimiento de los procesos que constituyen las competencias ambientales, pero los estudiantes mostraron un alto porcentaje de interés en el aprendizaje y los profesores contribuyeron en el diseño de estrategias didácticas para la enseñanza de las ciencias naturales y la educación ambiental.
Análisis de las Noticias Periodísticas en los Diarios El Comercio y El Universo sobre la Crisis Carcelaria en Ecuador
Authors: Chacaguasay Naranjo Adela Carolina 
Published: May 2024

El presente trabajo de investigación indaga a cerca de las noticias publicadas en la red social Facebook del Diario El Comercio y Diario El Universo durante la crisis carcelaria del sistema penitenciario del Litoral en Ecuador en el mes de noviembre del año 2021. Este episodio ha marcado de manera significativa a la sociedad ecuatoriana, medios de comunicación y el país entero, Facebook siendo una de las redes sociales con mayor preferencia de la ciudadanía para consumir información, fue utilizada como fuente principal para manifestar cualquier tipo de noticia referente al proceso de crisis carcelaria. Análisis que determina como se llevó a cabo el proceso de comunicación durante este periodo de crisis, Diario El Comercio y El Universo, publicaron un total de 120 noticias redactadas al instante del desarrollo de los hechos, de la misma forma nos dan a conocer el impacto de las mismas en la sociedad ecuatoriana, las reacciones, comentarios y opinión publica nos han dado a conocer cómo afecta una noticia mal realizada. En medio de esta crisis, se dio un intercambio de noticias entre los ciudadanos, la desinformación y la mala utilización de los medios creó una nueva crisis dentro de la sociedad. A pesar de que se realizó un gran esfuerzo por compartir información real, no se pudo tener un control sobre los ciudadanos que publicaban en la red durante la crisis, esto debido a que es una plataforma gratuita y de libre acceso al público.
Mansplaining with Ovid: Ars–cultus–munditia and the ‘Natural’ Body
Authors: Johnson Marguerite 
Published: May 2024

Chapter 9 by Marguerite Johnson examines Ovid’s preference for unadorned female elegance and examines the tensions exhibited in his work between natural beauty on the one hand, and – ironically – the efforts required to achieve it, on the other. This approach not only places emphasis on technosômata in Ovidian Rome, but also brings to prominence the male-imposed value system of bodily aesthetics for women, which he champions. The chapter privileges not only the written artefact in the form of Ovid’s poetry, but the material artefact as well, in its consideration of the recipes and various beauty accoutrements mentioned in the Medicamina in relation to the archaeological evidence.
Politics of Representation in Mountaineering
Authors: Hall Jenny , Hall Martin 
Published: May 2024

This chapter summarises the findings of the work in the book and crucially, proposes the new avenues of work which need to be completed. There are ideas uncovered in this volume which as questions for new areas of scholarship and this chapter investigates how effectively the collected works here have questioned the scope of mountain literature, and have nuanced dominant narratives of consumption within leisure and tourism spaces by contributing novel accounts of mountain environments and the communities associated therein. The chapters acknowledges the dominance of Western academic voices and subjects in this volume and call upon academics to take seriously issues of inclusion across multiple axes of social distinction.
Stability for Cauchy problem of first order linear PDEs on $ \mathbb{T}^m $ with forced frequency possessing finite uniform Diophantine exponent
Authors: Guan Xinyu , Kang Nan 
Published: May 2024

<abstract><p>In this paper, we studied the stability of the Cauchy problem for a class of first-order linear quasi-periodically forced PDEs on the $ m $-dimensional torus:</p>

<p><disp-formula> <label/> <tex-math id="FE1"> \begin{document}$ \begin{eqnarray*} \left\{	\begin{array}{l}	\partial_t u+(\xi+f(x, \omega t, \xi))\cdot \partial_x u = 0, \\	u(x, 0) = u_0(x), \	\end{array} \right. \end{eqnarray*} $\end{document} </tex-math></disp-formula></p>

<p>where $ \xi\in \mathbb{R}^m, x\in \mathbb{T}^m, \omega\in\mathbb{R}^d, $ in the case of multidimensional Liouvillean forced frequency. We proved that for each compact set $ \mathcal{O}\in\mathbb{R}^m $ there exists a Cantor subset $ \mathcal{O}_\gamma $ of $ \mathcal{O} $ with positive Lebesgue measure such that if $ \xi\in\mathcal{O}_\gamma, $ then for a perturbation $ f $ being small in some analytic Sobolev norm, there exists a bounded and invertible quasi-periodic family of linear operator $ \Psi(\omega t) $, such that the above PDEs are reduced by the transformation $ v: = \Psi(\omega t)^{-1}[u] $ into the following PDE:</p>

<p><disp-formula> <label/> <tex-math id="FE2"> \begin{document}$ \begin{eqnarray*} \partial_t v+ (\xi+ m_\infty(\omega t))\cdot\partial_x v = 0, \end{eqnarray*} $\end{document} </tex-math></disp-formula></p>

<p>provided that the forced frequency $ \omega\in \mathbb{R}^d $ possesses finite <italic>uniform Diophantine exponent</italic>, which allows Liouvillean frequency. The reducibility can immediately cause the stability of the above Cauchy problem, that is, the analytic Sobolev norms of the Cauchy problem are controlled uniformly in time. The proof is based on a finite dimensional Kolmogorov-Arnold-Moser (KAM) theory for quasi-periodically forced linear vector fields with multidimensional Liouvillean forced frequency. As we know, the results on Liouvillean frequency existing in the literature deal with two-dimensional frequency and exploit the theory of continued fractions to control the small divisor problem. The results in this paper partially extend the analysis to higher-dimensional frequency and impose a weak nonresonance condition, i.e., the forced frequency $ \omega $ possesses finite <italic>uniform Diophantine exponent</italic>. Our result can be regarded as a generalization of analytic cases in the work [R. Feola, F. Giuliani, R. Montalto and M, Procesi, Reducibility of first order linear operators on tori via Moser's theorem, <italic>J. Funct. Anal.</italic>, 2019] from Diophantine frequency to Liouvillean frequency.</p></abstract>
Engineering Dimeric EGFR-directed IgA Antibodies Reveals a Central Role of CD147 during Neutrophil-mediated Tumor Cell Killing of Head and Neck Squamous Cancer Cells
Authors: Zwick Anabel , Braun Felix Leon , Weber Lennert Jochen , Linder Manuel , Linxweiler Maximilian , Lohse Stefan 
Published: May 2024

Abstract
Human IgA Abs engage neutrophils for cancer immunotherapy more effectively than IgG Abs. Previous studies demonstrated that engineering approaches improved biochemical and functional properties. In this study, we report a novel, to our knowledge, IgA2 Ab against the epidermal growth factor receptor generated by protein engineering and polymerization. The resulting molecule demonstrated a covalent linkage of L and H chains and an effective polymerization by the joining chain. The engineered dimer outperformed its monomeric variant in functional experiments on Fab-mediated modes of action and binding to the Fc receptor. The capacity to engage neutrophils for Ab-dependent cell-mediated cytotoxicity (ADCC) of adherent growing target cancer cells was cell line dependent. Although the engineered dimer displayed a long-term efficacy against the vulva carcinoma cell line A431, there was a notable in-efficacy against human papillomavirus (HPV)− head and neck squamous cell carcinoma (HNSCC) cell lines. However, the highly engineered IgA Abs triggered a neutrophil-mediated cytotoxicity against HPV+ HNSCC cell lines. Short-term ADCC efficacy correlated with the target cells’ epidermal growth factor receptor expression and the ability of cancer cell–conditioned media to enhance the CD147 surface level on neutrophils. Notably, the HPV+ HNSCC cell lines demonstrated a significant increment in releasing soluble CD147 and a reduced induction of membranous CD147 on neutrophils compared with HPV− cells. Although membranous CD147 on neutrophils may impair proper IgA–Fc receptor binding, soluble CD147 enhanced the IgA–neutrophil-mediated ADCC in a dose-dependent manner. Thus, engineering IgA Abs and impedance-based ADCC assays provided valuable information regarding the target–effector cell interaction and identified CD147 as a putative critical parameter for neutrophil-mediated cytotoxicity.
Comparative Evaluation of Antitumor Chinese Patent Medicine Injections Based on Evidence-Based Medicine and Markov Model
Authors: Yang Jing , Wang Yan-Peng , Yu Wen-Gong , Guan Yu-Yao , Amponsah Prince Emmanuel Opoku , Tang Xian-Shuai , Sun Ying-Zi , Zheng Lei 
Published: May 2024

Abstract

Objective:
The objective of this study was to explore the safety, efficacy, economy, and other aspects of frequently-used antitumor Chinese patent medicine injections through a comprehensive evaluation of evidence-based medical research to provide scientific information and decision-making basis for drug selection, rational drug use, public awareness of safe drug use, and medical insurance.

Materials and Methods:
The names of five frequently used antitumor Chinese patent medicine injections were used as search terms, including the compound Sophora flavescens injection, Kangai injection, Aidi injection, Kanglaite injection, and Brucea javanica oil emulsion injection. Relevant evidence-based medical research was extracted from the databases. A descriptive evaluation was conducted, and the Markov model was used for the cost-benefit analysis. Finally, the above injections are ranked by comprehensive scores using the multi-criteria decision analysis and Delphi method.

Results:
The five injections had their own advantages in enhancing the effectiveness of anti-tumor treatments, improving the quality of life for cancer patients, and reducing the incidence of adverse reactions. From the perspective of economy and other attributes, compound S. flavescens was superior to B. javanica oil, Aidi, Kangai, and Kanglaite. After a comprehensive evaluation of the above five injections, the compound S. flavescens injection received the highest score.

Conclusions:
Compound S. flavescens, Kangai, Aidi, B. javanica oil, and Kanglaite have their own advantages in effectiveness and no significant difference in safety. Compound S. flavescens injection has the highest comprehensive score. Clinical attention should be paid to monitoring the initial stage of medication and special groups.
Alteration of T-cell and monocyte subsets in patients with immune thrombocytopenia: glucocorticoids versus immunosuppressant drugs
Authors: Nafady Asmaa , Nafady-Hego Hanaa , Shhata Nada A , El Khalek Fatma A , Ahmed Shimaa A , Elsaied Abdelrahman A 
Published: May 2024

Abstract

Background
Several therapy approaches are currently in use, each focusing on a different element of primary immune thrombocytopenia (ITP) pathogenesis. Human T-lymphocytes and monocytes are heterogeneous and play an important role in autoimmune diseases. However, the distribution and function of mononuclear cells remain unclear in ITP after therapy.

Aim
To evaluate the effect of glucocorticoid hormones and other immunosuppressant drugs in patients with ITP on lymphocyte and monocyte subsets and correlate changes between drug responders and nonresponders.

Patients and methods
A randomized cross-sectional case–control study was conducted on 130 participants, who were divided into two groups: 50 patients with ITP and 80 healthy controls. The patients were randomly treated with either steroids, azathioprine, or revolade in the Department of Internal Medicine of Qena University Hospital between April 2021 and April 2022. The research was conducted at the Department of Clinical Pathology of Qena University Hospital.

Results
Treatment with steroids, azathioprine, or revolade showed increased CD3-expressing cells and improved platelets and platelet/lymphocyte ratios. Steroid therapy also increased hemoglobin levels, leukocyte numbers, neutrophil counts, monocyte counts, and monocyte–lymphocyte ratios. Leukocyte count was increased by azathioprine treatment, whereas leukocyte, neutrophil, and monocyte/lymphocyte counts were increased by revolade treatment. Azithromycin and revolade therapy decreased CD14 count and increased CD16 fraction. Azithromycin treatment increased CD4 cells, whereas steroid treatment boosted CD8 cells. Additionally, in comparison with controls, patients had considerably less classical monocytes. However, patients had significantly more nonclassical monocytes and intermediate than controls did. Nonclassical and intermediate monocytes showed a significant reduction. Treatment responders were much older than nonresponders. The hazard ratio of monocyte/lymphocyte ratio was 0.002 (95% confidence interval: 0–0.55) and for neutrophil/lymphocyte ratio was 1.82 (95% confidence interval: 1.04–3.16), with P values of 0.04 and 0.03, respectively.

Conclusion
The modification of monocytes and lymphocytes in ITP following treatment can provide insight into the significance of these cells and the likelihood of using it to monitor patients while they are receiving treatment.
Semiquantitative measurements of standardized uptake value in assessment of response and outcomes in patients with lymphoma
Authors: Al-Agizy Hagar A , Tawfek Eman A , Abd El-Ghany Ashraf E , Ahmed Mohamed E , Hebesh Eman H , Gohar Suzy F 
Published: May 2024

Abstract

Objectives
To evaluate the accuracy of semiquantitative measurements of standardized uptake value (ΔSUVmax) in the assessment of response to treatment in patients with lymphoma.

Background
Positron emission tomography (PET) with 2-[18 F]-fluoro-2-deoxy-D-glucose is an essential tool for accurate staging and early and late therapy response assessments in all 2-[18 F]-fluoro-2-deoxy-D-glucose -avid histologies.

Patients and methods
The study included 73 patients diagnosed as having diffuse large B-cell lymphoma or Hodgkin’s disease. PET/CT examinations were performed at baseline (PET0), then after 2 cycles of chemotherapy (PET 2), and after 4 cycles of chemotherapy (PET4). PET scans were analyzed according to Deauville five-point scale, and cutoff values for changes in the maximum standardized uptake value (SUVmax). The change in activity (ΔSUV) from initial (SUVmax1) to later scans (SUVmax2) was calculated. Biopsy was also taken when PET4 was visually positive but delta SUVmax was negative or in case of new lesions if other sites have improved.

Results
In comparison with the results of biopsy, ΔSUV0-2 had 80% sensitivity, 94.1% specificity, and 90.91% accuracy, with significant P value of 0.001. Moreover, ΔSUV0–4 had sensitivity of 80%, specificity of 100%, and accuracy of 95.45%, with high agreement k(P) 0.861 with significant P value less than 0.001. On the contrary, the visual five-point scale analysis specificity was 17.65% and accuracy was 36.36%, with insignificant P value less than 0.321. Neither the Deauville criteria nor ΔSUVmax was significantly associated with time to progression and overall survival.

Conclusion
ΔSUVmax is comparable to biopsy and significantly more accurate than Deauville criteria in response assessment to chemotherapy.
Diagnostic value and biological significance of CD71 in lymphoid disorders
Authors: Mahmoud Maged S , Eldeen Taghreed M K , Fahmy Marwa A E S 
Published: May 2024

Abstract

Background
The CD71 expression is tightly regulated by intracellular iron level, cell proliferation, or erythropoiesis at levels of receptor recycling, as well as transcriptional or posttranscriptional control. In the previous studies, CD71 was expressed by most of acute leukemia and chronic granulocytic leukemia in blast crisis with a variable density of expression. Only few studies have observed CD71 as a diagnostic and prognostic marker in cases of acute lymphocytic leukemia (ALL) as a type of acute leukemia. Therefore, our study aimed to evaluate the diagnostic and biological significance of CD71 in lymphoid disorders.

Aim and objectives
This study aimed to evaluate the diagnostic value and biological significance of CD71 in lymphoid disorders.

Patients and methods
The present research was carried out on 60 patients diagnosed with lymphoid disorders (benign lymphocytosis, ALL, CLL, lymphoma, and multiple myeloma) who presented to Assiut University Hospital from July 2020 till July 2021.

Results
CD71 expression was significantly higher in acute disorders (immature cell-type tumors of malignant lymphoid disorders) than in benign lymphocytosis and chronic disorders (immature cell-type tumors of malignant lymphoid disorders), with strong relation with the positivity of CD34 and TdT.

Conclusion
CD71 helps to differentiate between lymphoid disorders and further helps in discriminating the differentiation status of ALL. High expression of CD71 might reflect a much more aggressive and immature cell type. However, further prospective investigations are needed to document the possible relation of CD71 with response to treatment and relapse rate. Moreover, high expression of CD71 with clonal evolution in leukemia may predict the possibility of being an important molecular target in future therapy of acute leukemia.