bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anisotropic Reinforcement of Acute Anteroapical Infarcts Improves Pump Function
Authors: Fomovsky Gregory M. , Clark Samantha A. , Parker Katherine M. , Ailawadi Gorav , Holmes Jeffrey W. 
Published: June 2012

Background—
We hypothesize that a therapy that improves left ventricular (LV) pump function early after infarction should decrease the need for compensation through sympathetic activation and dilation, thereby reducing the risk of developing heart failure. The mechanical properties of healing myocardial infarcts are an important determinant of LV function, yet improving function by altering infarct properties has proven unexpectedly difficult. Using a computational model, we recently predicted that stiffening a large anterior infarct anisotropically (in only one direction) would improve LV function, whereas isotropic stiffening, the focus of previous studies and therapies, would not. The goal of this study was to test the novel strategy of anisotropic infarct reinforcement.

Methods and Results—
We tested the effects of anisotropic infarct reinforcement in 10 open-chest dogs with large anteroapical infarcts that depressed LV pump function. We measured regional mechanics, LV volumes, and cardiac output at a range of preloads at baseline, 45 minutes after coronary ligation (ischemia), and 30 minutes later, after surgical reinforcement in the longitudinal direction (anisotropic). Ischemia shifted the end-systolic pressure–volume relationship and cardiac output curves rightward, decreasing cardiac output at matched end-diastolic pressure by 44%. Anisotropic reinforcement significantly improved systolic function without impairing diastolic function, recovering half the deficit in overall LV function.

Conclusions—
We conclude that anisotropic reinforcement is a promising new approach to improving LV function after a large myocardial infarction.
On the Equivalence of Two Schemes for Convective Momentum Transport
Authors: Romps David M. 
Published: June 2012

Abstract
The Gregory–Kershaw–Inness (GKI) parameterization of convective momentum transport, which has a tunable parameter C, is shown to be identical to a parameterization with no pressure gradient force and a mass flux smaller by a factor of 1 − C. Using cloud-resolving simulations, the transilient matrix for momentum is diagnosed for deep convection in radiative–convective equilibrium. Using this transilient matrix, it is shown that the GKI scheme underestimates the compensating subsidence of momentum by a factor of 1 − C, as predicted. This result is confirmed using a large-eddy simulation.
Local and Remote Climate Impacts from Expansion of Woody Biomass for Bioenergy Feedstock in the Southeastern United States
Authors: Murphy Lisa N. , Riley William J. , Collins William D. 
Published: June 2012

Many efforts have been taken to find energy alternatives to reduce anthropogenic influences on climate. Recent studies have shown that using land for bioenergy plantations may be more cost effective and provide a greater potential for CO2 abatement than using land for carbon sequestration. Native southern U.S. pines (i.e., loblolly) have excellent potential as bioenergy feedstocks. However, the land-cover change due to expansion of biofuels may impact climate through biophysical feedbacks. Here, the authors access the local and remote consequences of greater forest management and biofuel feedstock expansion on climate and hydrology using a global climate model, the NCAR Community Climate System Model, version 4 (CCSM4). The authors examine a plausible U.S. Department of Energy (DOE) biofuel feedstock goal by afforesting 50 million acres of C4 grasslands in the southeastern United States with an optimized loblolly plant functional type. Changes in sensible and latent heat fluxes are related to increased surface roughness, reduced bare-ground evaporation, and changes in stomatal conductance. In the coupled simulations, these mechanisms lead to a 1°C cooling, higher atmospheric stability, and a more shallow planetary boundary layer over the southeastern United States during the summer; in winter, a cooling of up to 0.25°C between 40° and 60°N, a weakened Aleutian low, and a wetter Australia occurs. A weakened Aleutian low shifts the North Pacific storm track poleward in the future loblolly scenarios. These local and global impacts suggest that biophysical feedbacks need to be considered when evaluating the benefits of bioenergy feedstock production.
Wind Field Characterization from the Trajectories of Small Balloons
Authors: Wilkerson Thomas D. , Marchant Alan B. , Apedaile Thomas J. 
Published: June 2012

AbstractThis paper reports the development and application of a new wind sensing system, ValidWind. ValidWind consists of small, helium-filled tracer balloons and an instrument that tracks them with high spatial resolution by means of an eye-safe lidar rangefinder and records 3D balloon position as a function of time. Lightweight retroreflectors attached to the balloons enhance the optical range. Balloon tracking is automatic. The data products include horizontal wind speed, wind direction, and vertical shear as functions of time and geolocation. Vertical wind speeds can be inferred from variations of the balloons’ rate of rise given the balance between buoyancy and aerodynamic drag. Applications of ValidWind include characterization of katabatic and ridge-top wind fields and monitoring of windborne aerosol transport. The capability of ValidWind balloons to provide useful profiles of the wind from the ground up to an altitude of 2 km AGL is presented and analyzed.
Evaluation of the Spatial and Temporal Uncertainties Distribution of Daily-Integrated Shortwave Downward Radiation Estimated from Polar-Orbiting Satellite Observation
Authors: Liu Yang , Liu Ronggao 
Published: June 2012

Abstract
The polar-orbiting satellite sensor, which can observe the entire Earth’s surface with good spatial and spectral resolution, is a potential tool for estimation of global downward shortwave radiation (DSR). However, it can only provide a couple of snapshots in one day, which should be extended to daily-integrated DSR in order to drive the ecosystem models. In this paper, the temporal and spatial uncertainties for estimating of daily-integrated DSR from instantaneous measurements of polar-orbiting satellites are evaluated using geostationary Geosynchronous Meteorological Satellite-5 (GMS-5) observations over East Asia. Those overpass times—including 1030, 1200, and 1330 local time (LT), which correspond to Terra/Moderate Resolution Imaging Spectroradiometer (MODIS), Sea-Viewing Wide Field-of-View Sensor (SeaWiFS), and Aqua/MODIS—are evaluated. The combinations of multiobservations are also assessed.
The results show that the daily-integrated DSR from polar-orbiting satellite observations of 1030, 1200, and 1330 underestimate solar radiation by 2.16% (0.46 MJ m−2), 5.44% (1.16 MJ m−2), and 5.54% (1.09 MJ m−2), with an RMSE of 2.05 MJ m−2 (12.92%), 2.50 MJ m−2 (13.33%), and 2.34 MJ m−2 (13.95%) in East Asia with large spatial and seasonal variations. In general, the bias is higher in the southern than in the northern part of East Asia. It is low in January, February, and March, then increases from April and reaches the maximum in June and July, and decreases rapidly to lower than 1.0 MJ m−2 in October. The uncertainties of daily-integrated DSR could be reduced by averaging multiday observations or combining of multitime observations. These uncertainties’ distributions are important for evaluation the usability of daily-integrated DSR from polar-orbiting satellite data and probably can be used for its calibration.
Comparison of Drop Size Distribution Parameter (D0) and Rain Rate from S-Band Dual-Polarized Ground Radar, TRMM Precipitation Radar (PR), and Combined PR–TMI: Two Events from Kwajalein Atoll
Authors: Bringi V. N. , Huang Gwo-Jong , Munchak S. Joseph , Kummerow Christian D. , Marks David A. , Wolff David B. 
Published: June 2012

Abstract
The estimation of the drop size distribution parameter [median volume diameter (D0)] and rain rate (R) from the Tropical Rainfall Measuring Mission (TRMM) precipitation radar (PR) as well as from combined PR–TRMM Microwave Imager (TMI) algorithms are considered in this study for two TRMM satellite overpasses near the Kwajalein Atoll. An operational dual-polarized S-band radar (KPOL) located in Kwajalein is central as the only TRMM ground validation site for measurement of precipitation over the open ocean. The accuracy of the TRMM PR in retrieving D0 and R is better for precipitation over the ocean based on a more stable surface reference technique for estimating the path-integrated attenuation. Also, combined PR–TMI methods are more accurate over the open ocean because of better knowledge of the surface microwave emissivity. Using Zh (horizontal polarized radar reflectivity) and Zdr (differential reflectivity) data for the two TRMM overpass events over Kwajalein, D0 and R from KPOL are retrieved. Herein, the main objective is to see if the D0 retrieved from either PR or the combined PR–TMI algorithms are in agreement with KPOL-derived values. Also, the variation of D0 versus R is compared for convective rain pixels from KPOL, PR, and PR–TMI. It is shown that the PR–TMI optimal estimation scheme does indeed adjust the D0 in the “correct” direction, on average, from the a priori state if the KPOL data are considered to be the ground truth. This correct adjustment may be considered as evidence of the value added by the TMI brightness temperatures in the combined PR–TMI variational scheme, at least for the two overpass events considered herein.
Near-Term Effects of the Lower Atmosphere in Simulated Northwest Flow Snowfall Forced over the Southern Appalachians
Authors: Miller Douglas K. 
Published: June 2012

Abstract
Northwest flow snowfall (NWFS) impacts the southern Appalachian Mountains after the upper-level trough has departed from the region, when moist northwesterly flow near the ground is lifted after encountering the mountains. Snowfall associated with these events is highly localized and challenging to predict as the clouds generating the accumulation are mesoscale in structure and depend on rapidly varying structures of moisture, instability, and wind in the planetary boundary layer (PBL) and on the relief of the local topography. The purpose of this study is to investigate the near-term impact of heat and moisture fluxes at the ground on the evolution of an NWFS event using several simulations of the Advanced Research core of the Weather Research and Forecasting mesoscale model. Model simulations indicate that convective banding is responsible for the snowfall accumulations in the southern Appalachians during the event and the structure of the banding is sensitive to the vertical positions of maximum wind shear and minimal stability within the PBL. Sensible heat fluxes at the ground upstream of the mountains in the daytime tend to deepen the PBL, reduce cloud water content, and reduce snowfall accumulations. At the same time, however, the daytime sensible heating also increases the overall vapor of the PBL through increased turbulent mixing and the transport of vapor made available to the atmosphere through upward latent heat fluxes at the ground. Latent heat fluxes at the ground upstream of the southern Appalachian Mountains provide a source of moisture that contributes a significant fraction of the overall simulated snowfall accumulations.
Tropical Cyclone Intensity Estimation in the North Atlantic Basin Using an Improved Deviation Angle Variance Technique
Authors: Ritchie Elizabeth A. , Valliere-Kelley Genevieve , Piñeros Miguel F. , Tyo J. Scott 
Published: June 2012

Abstract
This paper describes results from an improvement to the objective deviation angle variance technique to estimate the intensity of tropical cyclones from satellite infrared imagery in the North Atlantic basin. The technique quantifies the level of organization of the infrared cloud signature of a tropical cyclone as an indirect measurement of its maximum wind speed. The major change described here is to use the National Hurricane Center’s best-track database to constrain the technique. Results are shown for the 2004–10 North Atlantic hurricane seasons and include an overall root-mean-square intensity error of 12.9 kt (6.6 m s−1, where 1 kt = 0.514 m s−1) and annual root-mean-square intensity errors ranging from 10.3 to 14.1 kt. A direct comparison between the previous version and the one reported here shows root-mean-square intensity error improvements in all years with a best improvement in 2009 from 17.9 to 10.6 kt and an overall improvement from 14.8 to 12.9 kt. In addition, samples from the 7-yr period are binned based on level of intensity and on the strength of environmental vertical wind shear as extracted from Statistical Hurricane Intensity Prediction Scheme (SHIPS) data. Preliminary results suggest that the deviation angle variance technique performs best at the weakest intensity categories of tropical storm through hurricane category 3, representing 90% of the samples, and then degrades in performance for hurricane categories 4 and 5. For environmental vertical wind shear, there is far less spread in the results with the technique performing better with increasing vertical wind shear.
Managing Diabetes in Patients With Diabetes of Long Duration
Authors: Triplitt Curtis L. 
Published: June 2012

Purpose The purpose of this article is to review clinical issues related to the management of hyperglycemia in older patients with diabetes of long duration. Conclusion Older adults represent an extensive proportion of patients with type 2 diabetes. Treatment goals need to be individualized to take into account comorbid conditions, life expectancy, diabetes complications, and the benefits of glycemic control. For both older patients and especially those with chronic renal insufficiency, the most important drug-related adverse effect to avoid is hypoglycemia, and avoidance of any severe hypoglycemia should be paramount. Patients with long duration of diabetes are often treated with insulin. Recent data show that glucagon-like peptide-1 receptor agonists may be used in combination with insulin for patients not achieving glycemic goals, with reductions in the doses of insulin used and with a low risk of hypoglycemia and possible weight loss.
Advantage of Guaraná (Paullinia cupana Mart.) Supplementation on Cadmium-induced Damages in Testis of Adult Wistar Rats
Authors: Leite Rodrigo P. , Predes Fabrícia S. , Monteiro Juliana C. , Freitas Karine M. , Wada Ronaldo S. , Dolder Heidi 
Published: June 2012

Paullinia cupana is an Amazonian bush whose seeds have long been used in folk medicine. However, most of the therapeutic properties attributed to this plant are broad and nonspecific, although an antioxidant activity has been reported. On the other hand, cadmium is a heavy metal known for increasing free radicals, hence resulting in cellular oxidative damages. This study was designed to evaluate whether Paullinia cupana is able to reduce cadmium-induced morphological impairment in Wistar rat testis. Adult male Wistar rats 110 days old were ip injected with cadmium (1.15 mg/kg BW [body weight]) and subsequently treated with P. cupana during 56 days. Furthermore, groups receiving either P. cupana extract or cadmium are mentioned. After the treatment period, testis samples were subjected to histological and stereological analyses. Moderate to severe testicular impairments were shown by the animals exposed to cadmium. However, the animals supplemented with P. cupana after cadmium exposure showed a significant decrease in the proportion of damaged seminiferous tubules. Also, P. cupana supplementation was effective in maintaining the number of Leydig cells per testis in the animals exposed to cadmium. In conclusion, P. cupana supplementation was partially efficient in preventing cadmium from damaging the testis of adult Wistar rats.
Increased RLS prevalence in children and adolescents with migraine: A case-control study
Authors: Seidel Stefan , Böck Andreas , Schlegel Werner , Kilic Arzu , Wagner Gudrun , Gelbmann Gloria , Hübenthal Almut , Kanbur Incifer , Natriashvili Sofia , Karwautz Andreas , Wöber Christian , Wöber-Bingöl Çiçek 
Published: June 2012

Background: Previous studies have reported an increased frequency of restless legs syndrome (RLS) in adult migraine patients. Until now, the frequency of RLS in pediatric patients has not been investigated. We set out to assess the frequency of RLS in children and adolescents with migraine compared to headache-free controls. Methods: We investigated 111 consecutive patients with a sole diagnosis of migraine with or without aura presenting to the Headache Unit at the Department of Child and Adolescent Psychiatry and 73 headache-free controls for the presence of RLS using a semistructured interview. In addition, we assessed the level of daytime sleepiness by means of the Epworth sleepiness scale (ESS). A second group of headache-free controls was screened for the presence of RLS using an online questionnaire. Results: The frequency of RLS in migraine patients was significantly higher than in controls (22% vs. 5% ( p < 0.001) and 8% ( p < 0.001)). Discussion: This is the first study suggesting an association between RLS and migraine in the pediatric population. Future studies are needed to determine the extent of sleep disruption in children and adolescents with migraine and comorbid RLS.
Mouse hematopoietic cell–targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging–like phenotype
Authors: Mantel Charlie , Messina-Graham Steven , Moh Akira , Cooper Scott , Hangoc Giao , Fu Xin-Yuan , Broxmeyer Hal E. 
Published: June 2012

Abstract
Nuclear transcription factor Stat3 is important for proper regulation of hematopoietic stem cell (HSC) and hematopoietic progenitor cell (HPC) proliferation, survival, and cytokine signaling responses. A new, noncanonical role for Stat3 in mitochondrial function has been discovered recently. However, there is little information on the role(s) of mitochondrial Stat3 in HSC/HPC function, especially potential effects of Stat3/mitochondrial dysregulation in human diseases. We investigated hematopoietic cell–targeted deletion of the STAT3 gene in HSCs/HPCs with a focus on mitochondrial function. We found that STAT3−/− mice, which have a very shortened lifespan, dysfunctional/dysregulated mitochondrial function and excessive reactive oxygen species production in HSCs/HPCs that coincides with pronounced defects in function. These animals have a blood phenotype with similarities to premature aging and to human diseases of myelodysplastic syndrome and myeloproliferative neoplasms such as erythroid dysplasia, anemia, excessive myeloproliferation, and lymphomyeloid ratio shifts. We show herein that the lifespan of STAT3−/− animals is lengthened by treatment with a reactive oxygen species scavenger, which lessened the severity of the blood phenotype. These data suggest a need for more detailed studies of role(s) of Stat3 in HSC/HPC mitochondrial function in human diseases and raise the idea that mitochondrial Stat3 could be used as a potential therapeutic target.
Ly6G ligation blocks recruitment of neutrophils via a β2-integrin–dependent mechanism
Authors: Wang Jun-Xia , Bair Angela M. , King Sandra L. , Shnayder Ruslan , Huang Ya-Fang , Shieh Chi-Chang , Soberman Roy J. , Fuhlbrigge Robert C. , Nigrovic Peter A. 
Published: June 2012

AbstractLy6G is a glycosylphosphatidylinositol (GPI)–anchored protein of unknown function that is commonly targeted to induce experimental neutrophil depletion in mice. In the present study, we found that doses of anti-Ly6G Abs too low to produce sustained neutropenia remained capable of inhibiting experimental arthritis, leaving joint tissues free of infiltrating neutrophils. Thioglycollate-stimulated peritonitis was also attenuated. No alteration in neutrophil apoptosis was observed, implicating impaired recruitment. Indeed, Ly6G ligation abrogated neutrophil migration toward LTB4 and other chemoattractants in a transwell system. Exploring the basis for this blockade, we identified colocalization of Ly6G and β2-integrins by confocal microscopy and confirmed close association by both coimmunoprecipitation and fluorescence lifetime imaging microscopy. Anti-Ly6G Ab impaired surface expression of β2-integrins in LTB4-stimulated neutrophils and mimicked CD11a blockade in inhibiting both ICAM-1 binding and firm adhesion to activated endothelium under flow conditions. Correspondingly, migration of β2-integrin–deficient neutrophils was no longer inhibited by anti-Ly6G. These results demonstrate that experimental targeting of Ly6G has functional effects on the neutrophil population and identify a previously unappreciated role for Ly6G as a modulator of neutrophil migration to sites of inflammation via a β2-integrin–dependent mechanism.
High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)–mediated inhibition of platelet production
Authors: Thon Jonathan N. , Devine Matthew T. , Jurak Begonja Antonija , Tibbitts Jay , Italiano Joseph E. 
Published: June 2012

Abstract
Proplatelet production represents a terminal stage of megakaryocyte development during which long, branching processes composed of platelet-sized swellings are extended and released into the surrounding culture. Whereas the cytoskeletal mechanics driving these transformations have been the focus of many studies, significant limitations in our ability to quantify the rate and extent of proplatelet production have restricted the field to qualitative analyses of a limited number of cells over short intervals. A novel high-content, quantitative, live-cell imaging assay using the IncuCyte system (Essen BioScience) was therefore developed to measure the rate and extent of megakaryocyte maturation and proplatelet production under live culture conditions for extended periods of time. As proof of concept, we used this system in the present study to establish a mechanism by which trastuzumab emtansine (T-DM1), an Ab-drug conjugate currently in clinical development for cancer, affects platelet production. High-content analysis of primary cell cultures revealed that T-DM1 is taken up by mouse megakaryocytes, inhibits megakaryocyte differentiation, and disrupts proplatelet formation by inducing abnormal tubulin organization and suppressing microtubule dynamic instability. Defining the pathways by which therapeutics such as T-DM1 affect megakaryocyte differentiation and proplatelet production may yield strategies to manage drug-induced thrombocytopenias.