bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring Pediatric Vision Care: Insights from Five Years of Referral Cases in the UCI Eye Mobile and Implications of COVID-19
Authors: Choi Elliot H. , Hong John D. , Suh Susie , Menezes Carolline Rodrigues , Walker Kimberly R. , Bui Joseph , Storch Annabelle , Torres Diana , Espinoza Jennifer , Shahraki Kourosh , Molina Iliana , Suh Donny W. 
Published: April 2024

Purpose:
To analyze referral rates, patient demographics, referral indications, and the impact of socioeconomic factors on ocular health from the University of California Irvine (UCI) Eye Mobile for Children, particularly during the coronavirus disease 2019 (COVID-19) pandemic.

Methods:
A retrospective chart review was performed on de-identified records of children examined on the UCI Eye Mobile. GraphPad Prism 10.0.0 and Python software were used for statistical analyses.

Results:

In the academic years from 2018 to 2022, 3,619 children received comprehensive eye examinations on the UCI Eye Mobile. Among them, 76 were referred to a pediatric ophthalmologist. The majority of these children were Hispanic (72.6%, 54 of 74), followed by Asian (10.9%, 8 of 74). A significant proportion (82.9%, 63 of 76) attended school districts with median incomes below that of Orange County. Statistically significant differences were found in age (
P
= .001; pre-COVID: 3.98 ± 1.08 years vs COVID: 5.75 ± 2.92 years) and gender (
P
= .023; pre-COVID female: 31 of 41 vs COVID female: 15 of 32) between the pre-COVID and COVID years. Additionally, there were significant differences in the proportion of children with hyperopia with astigmatism between the pre-COVID and COVID years (
P
= .044; pre-COVID: 23 of 40 vs COVID: 12 of 35). The most common indications for ophthalmologist referrals were for strabismus evaluation/treatment (28.9%, 22 of 76), followed by abnormal cup-to-disc ratio (21.1%, 16 of 76).

Conclusions:
The study highlights the pivotal role of the UCI Eye Mobile for children in identifying ocular conditions needing referrals to subspecialty care. The majority of children needing these referrals attended schools in lower economic communities. Additionally, the COVID-19 pandemic appears to have influenced the demographic and clinical characteristics.

[
J Pediatr Ophthalmol Strabismus
. 2024;61(5):309–316.]
Génétique « textuelle » et adaptations transmédiatiques
Authors: Boillat Alain 
Published: April 2024

La réflexion menée dans cette étude se propose, tout en faisant un état des lieux commenté des recherches en critique génétique portant sur des adaptations (en particulier cinématographiques), de déployer et d’examiner les termes du paradoxe qui réside dans le fait que, bien que l’adaptation puisse être considérée, comme l’auteur le démontre ici, comme un objet intrinsèquement génétique appelant une démarche comparative, elle n’a été à ce jour que très peu discutée à l’aune de la méthodologie de cette discipline. Ce constat tient notamment à une hiérarchie des valeurs qui tend à instaurer un rapport d’inféodation du médium-cible à une œuvre originale bénéficiant d’une légitimation culturelle supérieure. Afin d’« adapter » la génétique à cet objet qui, dans différents médias, implique une pluri-stratification sémiotique, l’auteur propose de ne plus concevoir cette approche comme strictement « textuelle », mais de l’ouvrir à d’autres types de phénomènes, lesquels, à l’instar de l’incarnation à l’écran d’un personnage romanesque par un interprète porteur de sa persona propre, n’en agissent pas moins sur certains textes (notamment scénaristiques) qui témoignent de la genèse de l’œuvre.
Les réécritures des Mystères de Paris d’Eugène Sue
Authors: Möschler Lena 
Published: April 2024

Le présent article est consacré aux réécritures du roman-feuilleton Les Mystères de Paris d’Eugène Sue au passage de la presse (1ère édition) au livre (2ᵉ et 3ᵉ éditions). Après avoir présenté la genèse de l’œuvre, l’autrice met en relation les variations textuelles avec les supports de publication des différentes versions. Ces supports, caractérisés par leur matérialité et leur signification culturelle, sont envisagés comme des médias. L’adaptation transmédiale de la presse au livre permet d’expliquer certaines variations de l’œuvre. Dans une analyse ancrée en linguistique textuelle, trois phénomènes narratifs et textuels qui témoignent du changement de support comme facteur de réécriture, sont pris en considération : le renforcement de la clôture du texte, les ajustements textuels lors de la disparition des coupes matérielles inhérentes à la publication dans la presse, et l’estompement de la présence de l’instance de narration.
Le scénario de bande dessinée, aval du roman et amont de l’album
Authors: Boillat Alain 
Published: April 2024

L’article examine trois états scénaristiques de la bande dessinée en deux tomes Moby Dick parue chez Delcourt en 2005, adaptation du roman homonyme de l’écrivain Herman Melville que les auteurs ont conçue comme une transposition dans un autre genre, la science-fiction. L’étude porte spécifiquement sur le stade de l’écriture, souvent négligé dans les recherches sur ce médium qui tendent à privilégier la conception visuelle. L’auteur de l’article discute comment la matière du roman est retravaillée au cours de la genèse scripturale et du transfert vers un autre genre qui affecte le monde représenté, et comment celle-ci programme la genèse graphique – laquelle s’avère très peu contrainte sur le plan de la composition tabulaire des planches –, dans un cas de figure où les deux auteurs ont travaillé de manière successive et quasi autonome. Ces modalités de la collaboration entre scénariste et dessinateur sont ensuite contextualisées par rapport à la diversité des pratiques existant dans ce médium, illustrée succinctement avec la genèse d’une autre œuvre, 1984, adaptation par Xavier Coste du roman de George Orwell parue en 2021 aux éditions Sarbacane, pensée comme un roman graphique et dont l’auteur a simultanément assumé les tâches de scénariste et de dessinateur.
impacto do Ciclo de Vida na relação entre Governança Corporativa e Custo de Capital das Organizações
Authors: Ames Alice Carolina , Hein Nelson 
Published: April 2024

Este estudo analisa a influência do ciclo de vida na relação entre a governança corporativa e o custo de capital. Para tanto, realizou-se uma pesquisa descritiva, archival e quantitativa. A população do estudo compreendeu todas as empresas brasileiras listadas na Brasil, Bolsa, Balcão [B]3, do período de 2015 a 2018. Os resultados da pesquisa apontaram que há uma relação entre o estágio do ciclo de vida da organização e o custo de capital implícito. Desta forma, empresas que estão em seus estágios iniciais investem mais em mecanismos de governança corporativa, e por estarem buscando um lugar no mercado, incorrem em maiores gastos e o custo de capital é mais elevado. Entretanto, foi evidenciado que o investimento em governança corporativa tende a ser atenuado no estágio de maturidade, esse fator pode estar atrelado a justificativa de que, por as empresas estarem mais equilibradas financeiramente e quanto as condutas internas, tenha-se um menor investimento adicional em governança corporativa. Por outro lado, questões do cenário econômico também podem afetar o custo de capital das empresas, dadas as oscilações do país analisado. Estas evidências contribuem para a literatura que se refere a governança corporativa e ao entendimento da distinção entre níveis de governança corporativa dependendo do estágio do ciclo de vida. Ademais, apenas no estágio de introdução que foi evidenciada uma relação positiva com o custo de capital implícito, ou seja, nesse estágio as organizações tendem a potencializar investimentos em governança e exige um aumento no custo do capital. Assim, alinhado com estudos anteriores, foi verificado que os regimes de governança podem mudar com o decorrer do tempo.
Effects of investment opportunities on firms' financial performance: a fresh look through a dynamic panel approach and multivariate analysis
Authors: Teixeira Norberto Batista Alexandre , Costa Ribeiro Prates Juliana , Gama Fully Bressan Valéria , Camargos Avelino Bruna 
Published: April 2024

The aim of this study is to investigate the macroeconomic component Investment Opportunities influence, extracted by the multivariate PCA method, on firms' financial performance. The analysis was conducted in two stages: i) Principal Component Analysis (PCA) to circumvent the multicollinearity problem and identification of the Investment Opportunities variable; and ii) Application of the Systemic Generalized Method of Moments (GMM) both to analyze the relationship between Investment Opportunities and firms' financial performance (measured by current and future ROE), and to correct for data endogeneity. The sample comprises 160 non-financial companies, with quarterly data from 2010 to 2020. We use the PCA method exploratively to identify the first principal component as the predictor variable in the econometric model. It was extracted from macroeconomic variables, which include GDP variation and activity indexes, confidence, and agents’ expectations in Brazilian economy. Finally, we applied the GMM panel data modeling. The results showed that the Investment Opportunities variable has a positive and significant effect on companies’ financial performance, with persistent effects in future quarters. Furthermore, we demonstrate that financial performance is highly responsive to these opportunities with significant results in all estimated models. This study makes a practical and theoretical contribution by demonstrating, through multivariate analysis, how economic conditions are important exogenous drivers of firm performance and competitive advantage.
Role of cancer ratio (serum LDH/pleural ADA) and carcinoembryonic antigen in diagnosis of malignant pleural effusion
Authors: Amer Ahmed M , Mohamed Kareeman G , Shibel Passant A , Fayiad Hussein E 
Published: April 2024

Abstract

Background
Pleural effusion may be malignant or nonmalignant, Cytology has been used in malignant pleural effusion (MPE) diagnosis due to its high specificity. Its sensitivity is about 0.6. Cancer ratio (CR) and carcinoembryonic antigen (CEA) may be used in MPE diagnosis.

Aim
Evaluate the role of CR and CEA as diagnostic markers of MPE and their role in differentiating different types of MPE.

Patients and methods
This cross-sectional study included 70 patients with pleural effusion admitted to Chest Department, Kasr Alainy Faculty of Medicine, Cairo University. Thirty-five patients had benign pleural effusions and 35 patients had MPE. Pleural fluid sample obtained from each patient for ADA, CEA, and serum LDH. CR and pleural fluid CEA were compared between patients with MPE and those with benign effusion.

Results
CR was statistically significantly higher in the malignant group (mean 23.66 ± 7.75) compared with benign group (mean 14.47 ± 11.42) with P value less than 0.001. CR cut-off value was 19.79, the sensitivity and specificity were 74.3 and 82.9%, respectively. Pleural fluid CEA had higher levels in malignant group (mean 104.78 ± 262.7) compared with benign group (mean 2.08 ± 2.49) with P value less than 0.001. The cut-off value of CEA was 3.4 U/l with sensitivity 74.3% and specificity 94.3%. Pleural fluid CEA was significantly higher in metastatic adenocarcinoma (mean 154.58 ± 314.53) compared with other types of malignancy (mean 9.34 ± 17.98) with P value less than 0.001.

Conclusion
CR and CEA could be used together as simple screening tests in cytology negative MPE with high specificity and sensitivity. CEA was significantly higher in metastatic adenocarcinoma compared with other types of malignancy and could be used to differentiate different types of MPE.
Correlation of Inflammatory Biomarkers (Interleukin-6, Interleukin-8, and Tumor Necrosis Factor-alpha) with Severity of Acute Pancreatitis
Authors: Bhowmick Mithu , Lal Mahesh , Kumawat Ashok 
Published: April 2024

Abstract

Background:
Early assessment of severity of acute pancreatitis is very essential for the selection of patients who will require intensive care to prevent local complications and organ dysfunction. Several scoring systems have been developed, but these require large number of clinical and biochemical parameters, making them overly complicated and cumbersome. There is a need to develop simple clinical investigations which would help in assessing the severity of acute pancreatitis. Hence, the present study is undertaken to evaluate the role of inflammatory biomarkers (interleukin-6 [IL-6], IL-8, and tumor necrosis factor-alpha [TNF-α]) in the assessment of severity in acute pancreatitis.

Materials and Methods:
This cross-sectional study was conducted at a tertiary care teaching hospital in North India and enrolled 50 patients with acute pancreatitis. Serum levels of IL-6, IL-8, and TNF-α were measured within 24 h of admission.

Results:
The levels of IL-6, IL-8, and TNF-α were found to be significantly higher in patients with severe pancreatitis as compared to mild disease. With a cutoff level of >46.379 pg/ml, IL-6 had a sensitivity of 96.15%, specificity of 95.83%, and diagnostic accuracy of 96% for predicting progression to severe acute pancreatitis. Similarly, IL-8 >39.54 pg/mL had a sensitivity of 92.31%, specificity of 91.67%, and diagnostic accuracy of 92%. TNF-α >11.80 pg/mL had a sensitivity of 53.85%, specificity of 95.83%, and diagnostic accuracy of 74%.

Conclusion:
The current study results suggests that IL-6 and IL-8 levels measured within 24 h of admission can be used for predicting progression to severe acute pancreatitis.
Serum Neutrophil Gelatinase-associated Lipocalin: A Potential Marker of Impending Acute Kidney Injury in Sepsis
Authors: Sapra Shelly , Goyal Laxmi Kant , Mathur Ajay , Jain Gunja 
Published: April 2024

Abstract

Introduction:
Kidney injury is an inherent component of sepsis. Serum creatinine (S. Cr) as a marker of kidney injury has certain pitfalls and may not rise until significant kidney function has been lost. This study evaluated neutrophil gelatinase-associated lipocalin (NGAL) as a marker of impending acute kidney injury (AKI) in sepsis.

Materials and Methods:
A hospital-based cross-sectional, observational analytic study was conducted during one calendar year among patients admitted to medicine wards/intensive care units of a tertiary care hospital in Western India. A total of 80 study participants of age above 18 years fulfilling the criteria of sepsis were recruited in the study according to the Sepsis-3 criteria. Patients below 18 years of age, pregnant women, patients with known kidney diseases, malignancies, autoimmune diseases, and exposure to nephrotoxic agents (i.e. aminoglycoside, angiotensin-converting-enzyme inhibitors, and contrast agents) within the past 2 months, and patients who failed to give consent were excluded from the study. Clinical and biochemical data were collected till Day 7. Sequential organ failure assessment (SOFA) scores were calculated on Day 1 and Day 3. NGAL levels were measured on Day 3.

Results:
The mean age was 48 ± 19 years, with a male preponderance (63.8%). The mean of SOFA score on Day 1 and Day 3 was 9.84 ± 3.19 and 13.75 ± 3.14, respectively. The mean serum NGAL levels on Day 3 were 436.78 ± 242.23 ng/ml. The mean serum urea on Day 7 (86.99 ± 22.88 mg/dL) was significantly higher than on Day 3 (38.64 ± 9.49 mg/dL) (P = 0.004). Similarly, the mean S. Cr on Day 7 (2.97 ± 1.45 mg/dL) was significantly higher than on Day 3 (0.82 ± 0.23 mg/dL) (P = 0.033). The estimated glomerular filtration rate (eGFR) on Day 7 (35.42 ± 18.99 mL/min/1.73 m2) was also significantly lower in comparison to Day 3 (117.67 ± 56.10 mL/min/1.73 m2) (P < 0.05). Serum NGAL showed a significant positive correlation with S. Cr on Day 3 (r = 0.3257, P = 0.003), Day 7 (r = 0.5944, P < 0.00001), and mean change in S. Cr (r = 0.5562, P < 0.00001). Serum NGAL showed a significant negative correlation with eGFR on Day 3 (r = −0.3061, P = 0.005), Day 7 (r = −0.4362, P = 0.00005), and mean change in eGFR (r = −0.1629, P < 0.0001). Receiver-operating curve analysis showed 90.9% sensitivity and 98.3% specificity of NGAL (cutoff value 152 ng/ml) to predict impending AKI.

Conclusion:
Traditional marker of renal dysfunction (S. Cr, eGFR) had a significant correlation with NGAL. NGAL can predict impending AKI in sepsis patients earlier than S. Cr or eGFR.
Awareness about Orthodontists’ Role in Treating Osa and Mouth Breathing among Otolaryngologists
Authors: Patel Anuj D. , Kubavat Ajay K. , Patel Khyati V. , Sejani Vishwa , Bhavsar Priyal , Patel Riddhi 
Published: April 2024

ABSTRACT

Background:
Orthodontic correction of dentofacial abnormalities is a crucial component of oral health because it enhances overall oral health-related quality of life, optimal function, periodontal health, and aesthetics. This study sought to determine whether otolaryngologists recommend patients to orthodontists, whether they are adequately knowledgeable about the fundamentals of orthodontics, and whether they check for orthodontic problems in their patients.

Materials and Method:
We conducted a survey study of otolaryngologists in Gujarat, India. Questionnaires were completed by 47 out of 60 otolaryngologists (response rate 78%).

Results:
In the assessment of the mouth breathers, a very low frequency of “always” examining the extra-oral features (18%) was found. Reasons otolaryngologists referred patients to orthodontists varied from mouth breathing 48% (23/47) to face or teeth asymmetry 87% (41/47). In the multivariable analyses for the effect of gender, work sector, or years of experience in the decision for orthodontic referral, we could not identify any significant predictors. A low frequency of awareness of orthodontists’ role in obstructive sleep apnoea, 48% (23/47) was found.

Conclusion:
In conclusion, the survey of otolaryngologists in Gujarat, India, revealed areas for improvement in awareness and practices related to orthodontic issues, particularly in cases of mouth breathing. The study highlighted a low frequency of examination of extraoral features and variability in referral patterns, emphasizing potential gaps in knowledge. Additionally, a low awareness of orthodontists’ role in treating obstructive sleep apnea was identified. Targeted educational interventions are recommended to enhance interdisciplinary communication and collaboration between otolaryngologists and orthodontists, ultimately fostering a more comprehensive approach to patient care for individuals with dentofacial deformities in Gujarat and potentially influencing practices on a broader scale.
Genome Sequencing - Changing the Pandemic Dynamics
Authors: Jaggi Namita 
Published: April 2024

Abstract
One single test that has completely changed the curve of the COVID-19 pandemic is the genome sequencing. Most commonly used vaccines during the pandemic such as mRNA vaccines from Pfizer and vector-based vaccine from serum institute of India could be developed in record time because of the availability of viral genome which was decoded as early as January 11, 2020, even before the pandemic had spread too many parts of the world. Sequencing has allowed COVID-19 to be the first virus whose spread is being monitored in real-time and on a global scale. During the pandemic, repeated viral gene sequencing helped detect new variants and analyze their origin and behavior.
Prevalence of Coronavirus Disease 2019 and its Impact on Public Mental Health in Rural versus Urban Population of Sindh, Pakistan: A Descriptive Cross-sectional Study
Authors: Otho Muhammad Suleman , Perveen S. 
Published: April 2024

Abstract

Background:
The pandemic of coronavirus disease 2019 (COVID-19) is an immense public mental health threat. Asia has a great mix of rural and urban populations which differ in health-care facilities. Its virulence is escalating the psychological impact but its epidemiological dynamics are still needed to be explored. Therefore, we explored the prevalence of COVID-19 and its impact on public mental health in rural versus urban adults aged 18–65 years in the province of Sindh, Pakistan.

Materials and Methods:
A cross-sectional survey was conducted in Sindh, Pakistan, from April to July 2021. Stratified random sampling was used for 1494 respondents. Seven rural and urban districts were chosen. After informed consent, information on demographics, depression, and anxiety was collected through structured questionnaires. Statistical analyses were performed by SPSS version 26 with mean ± standard deviation for continuous and frequency (percentages) for categorical variables. t-test and Chi-square test were applied at P ≤ 0.05.

Results:
The prevalence of COVID-19 was found to be 20.9% in Sindh, Pakistan. Among 1494 respondents, the rural–urban distribution was 757 (50.7%) and 737 (49.3%) with females on the slightly higher side (774 [51.9%]). There was a statistically significant difference in age, household members, earning members, gender, marital status, and occupation. Prevalence of depression and anxiety was 42.2% and 85.5%, respectively. Both were statistically significant for rural–urban populations with P < 0.001 for depression and P = 0.003 for anxiety.

Conclusion:
The study showed a significant difference in the public mental health of the equitable rural versus urban population of Sindh, Pakistan, during the COVID-19 pandemic, which requires strategies by policymakers.
Stories are Central to the Collective Human Identity and so is Health
Authors: Raina Sunil Kumar 
Published: April 2024

Abstract
The failure of public health to achieve its objective is ingrained partly in its inability to adapt to change and partly to its preference for evidence-only models. The arrival and elevated emphasis on statistics and calculus as defining the success of systems and the extension of the same to public health has only worked toward strengthening its overreliance on evidence-only implementation strategies and models. However, public health, unlike medicine and more like social sciences gains from its application to the broader public good and takes its lessons more from the success stories among the public than from the calculation based on a few datasets. There is no public health without public and since stories are central to the construction of the public, there underutilization in the delivery of public health needs a relook.