bluuebunny/crossref_metadata_2025_split huggingface dataset:
Up-regulation of intestinal type 1 taste receptor 3 and sodium glucose luminal transporter-1 expression and increased sucrose intake in mice lacking gut microbiota
Authors: Swartz T. D. , Duca F. A. , de Wouters T. , Sakar Y. , Covasa M. 
Published: July 2011

The chemosensory components shared by both lingual and intestinal epithelium play a critical role in food consumption and the regulation of intestinal functions. In addition to nutrient signals, other luminal contents, including micro-organisms, are important in signalling across the gastrointestinal mucosa and initiating changes in digestive functions. A potential role of gut microbiota in influencing food intake, energy homeostasis and weight gain has been suggested. However, whether gut microbiota modulates the expression of nutrient-responsive receptors and transporters, leading to altered food consumption, is unknown. Thus, we examined the preference for nutritive (sucrose) and non-nutritive (saccharin) sweet solutions in germ-free (GF, C57BL/6J) mice compared with conventional (CV, C57BL/6J) control mice using a two-bottle preference test. Then, we quantified mRNA and protein expression of the sweet signalling protein type 1 taste receptor 3 (T1R3) and α-gustducin and Na glucose luminal transporter-1 (SGLT-1) of the intestinal epithelium of both CV and GF mice. Additionally, we measured gene expression of T1R2, T1R3 and α-gustducin in the lingual epithelium. We found that, while the preference for sucrose was similar between the groups, GF mice consumed more of the high concentration (8 %) of sucrose solution than CV mice. There was no difference in either the intake of or the preference for saccharin. GF mice expressed significantly more T1R3 and SGLT-1 mRNA and protein in the intestinal epithelium compared with CV mice; however, lingual taste receptor mRNA expression was similar between the groups. We conclude that the absence of intestinal microbiota alters the expression of sweet taste receptors and GLUT in the proximal small intestine, which is associated with increased consumption of nutritive sweet solutions.
White-matter abnormalities in the right posterior hemisphere in generalized anxiety disorder: a diffusion imaging study
Authors: Brambilla P. , Como G. , Isola M. , Taboga F. , Zuliani R. , Goljevscek S. , Ragogna M. , Brondani G. , Baiano M. , Perini L. , Ferro A. , Bazzocchi M. , Zuiani C. , Balestrieri M. 
Published: July 2011

BackgroundPrior imaging studies have shown structural, functional and biochemical impairments in patients with generalized anxiety disorder (GAD), particularly in the right hemisphere. In this study we investigated, for the first time to the best of our knowledge, the white-matter microstructure organization in GAD.MethodA total of 12 patients with DSM-IV GAD and 15 matched healthy controls underwent a magnetic resonance imaging session of diffusion weighted imaging, exploring white-matter water molecules by the means of apparent diffusion coefficients (ADCs). Regions of interests were placed in the frontal, parietal, temporal and occipital lobes and in the splenium and genu of the corpus callosum, bilaterally.ResultsADC measures were significantly greater in patients with GAD in the right splenium and right parietal cortex compared with healthy controls (p⩽0.002). No significant correlations between ADCs and age or clinical variables were found.ConclusionsWe provide evidence that GAD is associated with disrupted white-matter coherence of posterior right hemisphere regions, which may partly sustain the impaired cognitive regulation of anxiety. Future diffusion imaging investigations are expected to better elucidate the communication between the parietal cortex and other right hemisphere regions in sustaining the cognitive processing of social and emotional stimuli in patients with GAD.
Predictors of cosmetic surgery and its effects on psychological factors and mental health: a population-based follow-up study among Norwegian females
Authors: von Soest T. , Kvalem I. L. , Wichstrøm L. 
Published: July 2011

BackgroundThere is limited information about psychological predictors of cosmetic surgery and how cosmetic surgery influences subsequent changes in mental health and overall appearance satisfaction. To date, there is a lack of studies examining this issue, whereby representative population samples are assessed at an age before cosmetic surgery is typically conducted and followed up after such surgery has commonly been performed.MethodWe obtained data from a survey study following 1597 adolescent females from a representative Norwegian sample over a 13-year period. Participants provided information on cosmetic surgery, appearance satisfaction, mental health, risky sexual behavior, drug use and conduct problems at two time-points (overall response rate 67%).ResultsOf all participants, 78 (4.9%) reported having undergone cosmetic surgery, of whom 71 were operated on during the course of the study and seven before the first data collection. Symptoms of depression and anxiety [odds ratio (OR) 1.66, 95% confidence interval (CI) 1.07–2.57] and a history of deliberate self-harm (OR 2.88, 95% CI 1.46–5.68), parasuicide (OR 3.29, 95% CI 1.53–7.08) and illicit drug use (OR 2.46, 95% CI 1.07–5.82) predicted prospective cosmetic surgery. Moreover, those who underwent surgery during the course of the study experienced a greater increase than other females in symptoms of depression and anxiety (t=2.07, p=0.04) and eating problems (t=2.71, p<0.01). Patients' use of alcohol also increased more than among non-patients (t=2.47, p=0.01).ConclusionsA series of mental health symptoms predict cosmetic surgery. Cosmetic surgery does not in turn seem to alleviate such mental health problems.
Change in psychosocial functioning and depressive symptoms during acute-phase cognitive therapy for depression
Authors: Dunn T. W. , Vittengl J. R. , Clark L. A. , Carmody T. , Thase M. E. , Jarrett R. B. 
Published: July 2011

BackgroundMajor depressive disorder (MDD) is highly prevalent, is recurrent, and impairs people's work, relationships and leisure. Acute-phase treatments improve psychosocial impairment associated with MDD, but how these improvements occur is unclear. In this study, we tested the hypotheses that reductions in depressive symptoms exceed, precede and predict improvements in psychosocial functioning.MethodPatients with recurrent MDD (n=523; 68% women, 81% Caucasian, mean age 42 years) received acute-phase cognitive therapy (CT). We measured functioning and symptom severity with the Social Adjustment Scale – Self-Report (SAS-SR), Range of Impaired Functioning Tool (RIFT), Beck Depression Inventory (BDI), Hamilton Rating Scale for Depression (HAMD) and Inventory for Depressive Symptomatology – Self-Report (IDS-SR). We tested cross-lagged correlations between functioning and symptoms measured at baseline and the beginning, middle and end of acute-phase CT.ResultsPre- to post-treatment improvement in psychosocial functioning and depressive symptoms was large and intercorrelated. Depressive symptoms improved more and sooner than did psychosocial functioning. However, among four assessments across the course of treatment, improvements in functioning more strongly predicted later improvement in symptoms than vice versa.ConclusionsImprovements in psychosocial functioning and depressive symptoms correlate substantially during acute-phase CT, and improvements in functioning may play a role in subsequent symptom reduction during acute-phase CT.
Demography of colonisation and the ageing population: population profiles and mortality in Swedish Sápmi, 1750–1900
Authors: KARLSSON LENA 
Published: July 2011

ABSTRACTThis paper examines population trends, age-specific death rates and causes of death for the elderly Sami and settlers during the colonisation era (between 1750 and 1900). The source material is a set of data files from the Demographic Data Base (DDB) at Umeå University that covers parish records from three different parishes. Early in the colonisation period (1750–1840) the Sami had a lower proportion of the elderly population (⩾60 years old), compared to the non-Sami and the rest of Sweden. At the end of the colonisation period (1841–1900), the proportion of elderly Sami increased and was above the proportion of elderly non-Sami and more similar to the rest of Sweden. The analysis also reveals that the differences in mortality rates among the elderly Sami and their non-Sami counterparts diminished during the entire colonisation era (1750–1900), mainly because of an increased infant mortality among the non-Sami. Rather than ethnic differences in causes of death, the results show larger differences between the parishes. The study can conclude that the Sami population's mortality declined, the health improved, and the Sami advanced more rapidly in the model of epidemiologic transition, a milestone not yet reached by other indigenous people around the world.
Second-first language acquisition: analysis of expressive language skills in a sample of girls adopted from China
Authors: TAN TONY XING , LOKER TROY , DEDRICK ROBERT F. , MARFO KOFI 
Published: July 2011

ABSTRACTIn this study we investigated adopted Chinese girls' expressive English language outcomes in relation to their age at adoption, chronological age, length of exposure to English and developmental risk status at the time of adoption. Vocabulary and phrase utterance data on 318 girls were collected from the adoptive mothers using the Language Development Survey (LDS) (Achenbach & Rescorla, 2000). The girls, aged 18–35 months (M=26·2 months, SD=4·9 months), were adopted at ages ranging from 6·8 to 24 months (M=12·6 months, SD=3·1 months), and had been exposed to English for periods ranging from 1·6 to 27·6 months (M=13·7, SD=5·7). Findings suggest that vocabulary and mean length of phrase scores were negatively correlated with age at adoption but positively correlated with chronological age and length of exposure to English. Developmental risk status at the time of adoption was not correlated with language outcomes. The gap between their expressive language and that of same-age girls from the US normative sample was wider for children aged 18–23 months but was closed for children aged 30–35 months. About 16% of the children met the LDS criteria for delays in vocabulary and 17% met the LDS criteria for delays in mean length of phrase. Speech/language interventions were received by 33·3% of the children with delays in vocabulary and 25% with delays in phrase.
An outbreak of sheep rabies in Shanxi province, China
Authors: ZHU Y. , ZHANG G. , SHAO M. , LEI Y. , JIANG Y. , TU C. 
Published: July 2011

SUMMARYThis study describes an outbreak of rabies in a flock of 110 sheep in Yangqu county, Shanxi province, China, in 2010. The flock, housed in a cave being used as a sheepfold, was attacked by a rabid dog, which resulted in 36 deaths over the following 2 days from the crushing and trampling caused by panic, and some 15 further deaths from rabies 2 weeks later. Rabies in the sheep was confirmed by the fluorescent antibody test (FAT) and RT–PCR. Rabies virus was isolated from the index dog brain and its N gene was partially sequenced (nucleotides 77-880). Results showed that the canine isolate (SXTYD01) was rabies virus with the N gene fragment 100% identical to that of the virus isolated from rabid sheep. This is the first confirmed sheep rabies outbreak in China. The clinical presentation of the disease is also described.
Evaluating interventions againstSalmonellain broiler chickens: applying synthesis research in support of quantitative exposure assessment
Authors: BUCHER O. , FAZIL A. , RAJIĆ A. , FARRAR A. , WILLS R. , McEWEN S. A. 
Published: July 2011

SUMMARYA scoping study and systematic review-meta-analyses (SR-MAs) were conducted to evaluate the effectiveness of various interventions forSalmonellain broiler chicken, from grow-out farm to secondary processing. The resulting information was used to inform a quantitative exposure assessment (QEA) comparing various control options within the context of broiler chicken production in Ontario, Canada. Multiple scenarios, including use of two separate on-farm interventions (CF3 competitive exclusion culture and a 2% lactose water additive), a package of processing interventions (a sodium hydroxide scald water disinfectant, a chlorinated post-evisceration spray, a trisodium phosphate pre-chill spray and chlorinated immersion chilling) a package consisting of these farm and processing interventions and a hypothetical scenario (reductions in between-flock prevalence and post-transport concentration), were simulated and compared to a baseline scenario. The package of on-farm and processing interventions was the most effective in achieving relative reductions (compared to baseline with no interventions) in the concentration and prevalence ofSalmonellaby the end of chilling ranging from 89·94% to 99·87% and 43·88% to 87·78%, respectively. Contaminated carcasses entering defeathering, reductions in concentration due to scalding and post-evisceration washing, and the potential for cross-contamination during chilling had the largest influence on the model outcomes under the current assumptions. Scoping study provided a transparent process for mapping out and selecting promising interventions, while SR-MA was useful for generating more precise and robust intervention effect estimates for QEA. Realization of the full potential of these methods was hampered by low methodological soundness and reporting of primary research in this area.
Modelling meningococcal meningitis in the African meningitis belt
Authors: IRVING T. J. , BLYUSS K. B. , COLIJN C. , TROTTER C. L. 
Published: July 2011

SUMMARYMeningococcal meningitis is a major public health problem in a large area of sub-Saharan Africa known as the meningitis belt. Disease incidence increases every dry season, before dying out with the first rains of the year. Large epidemics, which can kill tens of thousands of people, occur frequently but unpredictably every 6–14 years. It has been suggested that these patterns may be attributable to complex interactions between the bacteria, human hosts and the environment. We used deterministic compartmental models to investigate how well simple model structures with seasonal forcing were able to qualitatively capture these patterns of disease. We showed that the complex and irregular timing of epidemics could be caused by the interaction of temporary immunity conferred by carriage of the bacteria together with seasonal changes in the transmissibility of infection. This suggests that population immunity is an important factor to include in models attempting to predict meningitis epidemics.
Contextual hypotheses and semantics of logic programs
Authors: MARTIN ÉRIC A. 
Published: July 2011

AbstractLogic programming has developed as a rich field, built over a logical substratum whose main constituent is a nonclassical form of negation, sometimes coexisting with classical negation. The field has seen the advent of a number of alternative semantics, with Kripke–Kleene semantics, the well-founded semantics, the stable model semantics, and the answer-set semantics standing out as the most successful. We show that all aforementioned semantics are particular cases of a generic semantics, in a framework where classical negation is the unique form of negation and where the literals in the bodies of the rules can be ‘marked’ to indicate that they can be the targets of hypotheses. A particular semantics then amounts to choosing a particular marking scheme and choosing a particular set of hypotheses. When a literal belongs to the chosen set of hypotheses, all marked occurrences of that literal in the body of a rule are assumed to be true, whereas the occurrences of that literal that have not been marked in the body of the rule are to be derived in order to contribute to the firing of the rule. Hence the notion of hypothetical reasoning that is presented in this framework is not based on making global assumptions, but more subtly on making local, contextual assumptions, taking effect as indicated by the chosen marking scheme on the basis of the chosen set of hypotheses. Our approach offers a unified view on the various semantics proposed in logic programming, classical in that only classical negation is used, and links the semantics of logic programs to mechanisms that endow rule-based systems with the power to harness hypothetical reasoning.
Agenda of the “BioSharing workshop - Unifying Bio-Resources Descriptors”
Authors: Sansone Susanna-Assunta , Rocca-Serra Philippe , Gaudet Pascale , Field Dawn 
Published: July 2011

AbstractOrganized by members of the BioSharing initiative (www.biosharing.org) and the International Society for Biocuration (ISB, www.biocurator.org), this workshop brought together developers, curators, journal editors and researchers to discuss the growing number of (closely related efforts) developing to catalogues of tools, databases, related data and publications.The focus on the workshop was a strawman uniform system for describing these bio-resources (www.biodbcore.org), in particular, indicating in a consistent manner which community-defined standards (minimal information checklists, terminologies and exchange formats) they implement (www.biosharing.org/standards).Location: ISMB/ECCB, Vienna.Date: July 18th, 2011.
Ya33 ‘give’ as a valency increaser in Jinghpo nuclear serialization
Authors: Peng Guozhen , Chappell Hilary 
Published: July 2011

This paper analyzes serial verb constructions in Jinghpo formed by ya33 ‘give’, arguing that it has the function of a valency–increasing device in nuclear serialization: The use of ya33 allows the licensing of an additional beneficiary argument as a core argument to the lexical verb. In a new twist, however, on the evolution of give verbs, we demonstrate that the benefactive usage is extended to malefactive semantics in a distinct, derived structure, conditioned via the expression of possession, a type of malefactive that is not well-documented in current literature on this domain.

Furthermore, the existence of two distinct constructions for the benefactive and the malefactive in Jinghpo conforms to Radetzky & Smith’s claim (2010: 116) that this is an areal feature comprising the Indian subcontinent, Southeast and East Asia, and thus contrasts strongly with the conflation of both types of construction in many European languages.
Finally, we propose that the nuclear type of serialization, integral to the typological profile of Jinghpo, a SOV language, is a determining factor in the reanalysis of ya33. This feature is subsequently invoked to explain why the malefactive usage of ya33 constitutes a separate development from the well-attested pathway for give verbs leading to permissive causative verbs and adversative passive markers, which, while blocked in Jinghpo, is commonly found in many other East and Southeast Asian languages with core serialization.
The present analysis is based on the variety of Jinghpo spoken in Luxi County, Yunnan Province, China, using, in the main, natural discourse data collected in the field.
Refrigerated Dough Quality of Hard Red Spring Wheat: Effect of Genotype and Environment on Dough Syruping and Arabinoxylan Production
Authors: Simsek Senay , Whitney Kristin , Ohm Jae‐Bom , Mergoum Mohamed 
Published: July 2011

ABSTRACTArabinoxylans (AX) are the main nonstarch polysaccharides found in wheat flour. Structural changes of AX in refrigerated dough are linked to deleterious effects on refrigerated dough quality during storage. The purpose of this research was to evaluate the effect of cultivar and growing environment on dough syruping during refrigerated storage in relation to apparent xylanase activity and AX chemistry in hard red spring (HRS) wheat. Eight HRS cultivars that were grown at six locations over two years in North Dakota were evaluated for dough syruping during 15 days of refrigerated storage. When compared with genotypic effect, growing environment had a greater impact on apparent xylanase activity and dough syruping; they were found to have significant associations by log‐linear regression analysis. Specifically, wheat samples produced in a dry environment had lower apparent xylanase activity and degree of dough syruping than those from a wet environment. Some HRS cultivars were identified to be consistently lower in apparent xylanase activity and dough syruping across all growing environments, indicating that those cultivars had more stability over growing environment than other cultivars. These results indicate that certain cultivars that are grown in relatively dry environments in North Dakota are more suitable for use in refrigerated dough formulations.
Development strategy of the alternative format materials for disabled people in Korea
Authors: Yoon Hee‐Yoon , Kim Sin‐Young 
Published: July 2011

PurposeDisabled people have the same information needs as non‐disabled people. Nevertheless, only 5 per cent of the world's publishing output is made accessible in alternative formats for people who cannot access and use printed materials. This paper aims to suggest the strategy for a national development plan, role models for production and distribution of the alternative format materials for the equitable library service for Koreans with print disabilities.Design/methodology/approachThe paper is based on a series of pre‐research studies and discusses arguments for and principles of an alternative format materials development plan in terms of protecting access to information, eliminating the knowledge and information gap, the role of libraries and their social responsibilities, the inadequacy of materials currently available, production plans at the national level, and the advent of an era of digital distribution.FindingsThis research presents a strategic development plan as well as a role division model concerning the production of alternative format materials based on the mid‐ to long‐term plan and a nation‐wide cooperative network centring on the National Library Support Center for Disabled People in Korea.Originality/valueThe strategic development plan and a role division model concerning the production of alternative format materials presented in this study will improve consciousness about the gap in information.