bluuebunny/crossref_metadata_2025_split huggingface dataset:
Micronutrient Status of Plantation Workers in Sri Lanka during Pregnancy and Postpartum
Authors: de Silva L. Dilip R. , Atukorala T. M. Sunethra 
Published: August 2010

AbstractIron, zinc and vitamin A status was assessed in 309 plantation workers during pregnancy and in a sub‐sample of 108 subjects at 20 to 36 weeks postpartum and the birth weights of their newborn were noted. A significant positive correlation was noted between haemoglobin concentration at 10–26 weeks of gestation of anaemic mothers (n = 180) and birth weights of their new born. Depleted iron stores (serum ferritin < 12 μg/l) were noted in 33.3% of subjects at 10–26 weeks of gestation. There was no significant change in serum ferritin concentration at > 32 weeks of gestation. Iron deficiency persisted at 20–36 weeks postpartum. Marginal vitamin A deficiency was also noted, as, 46.2% and 15.6% of the subjects respectively, had low serum vitamin A levels in pregnancy and postpartum. Low serum zinc levels were noted only in pregnancy. Iron supplementation during pregnancy was only effective in preventing further deterioration in iron status and it should be continued for about 12 weeks after delivery.
Serum Levels of Squamous Cell Carcinoma Antigen and Carcinoembryonic Antigen as Tumor Markers of Vulvar Cancer
Authors: Yamawaki Takaharu , Takeshima Nobuhiro , Shimizu Yoshio , Teshima Hideo , Hasumi Katsuhiko 
Published: August 2010

AbstractObjective: To assess whether squamous cell carcinoma (SCC) antigen and carcinoembryonic antigen (CEA) are useful as tumor markers of vulvar cancer.Methods: The serum levels of SCC antigen and CEA were determined for 30 patients with invasive vulvar carcinoma.Results: There was a significant difference not only between tumor sizes of 2 cm or larger and those of less than 2 cm (p < 0.001), but also between patients with lymph node metastasis and patients free from it (p < 0.001). Tumor marker levels well reflected the response to neoadjuvant chemotherapy. The sensitivity to recurrence was 63%, and the specificity was 94%. In 2 of 8 recurrent cases, it was only the re‐increase in tumor markers that indicated the recurrence.Conclusion: The measurement of serum levels of SCC antigen and CEA is useful not only for preoperative evaluation of the risk of lymph node metastasis, but also for the detection of recurrence.
Case Report: An Exaggerated Placental Site with a Cervical Pregnancy
Authors: Kase Hiroaki , Kodama Shoji , Yahata Tetsuro , Aoki Yoichi , Tanaka Kenichi 
Published: August 2010

AbstractAn exaggerated placental site (EXPS) is an exuberant nonneoplastic proliferation of the intermediate trophoblast at the implantation site. We had a case of an EXPS with a cervical pregnancy. We report on this case, including the patient's clinical course and immunohistological findings.
Laparoscopic Assisted Vecchietti Procedure for the Creation of a Neovagina
Authors: Cooper Michael J. W. , Fleming Sue , Murray John 
Published: August 2010

AbstractA case report of a 21‐year‐old patient with Mayer‐von Rokitansky‐Küster‐Hauser syndrome is presented. A neovagina was created by drawing an olive into the vaginal grove and applying continuous tension via sutures passed at laparoscopy to a tensioning device on the anterior abdominal wall.
Outcome of External Cephalic Version: Our Experience
Authors: Teoh Terence 
Published: August 2010

AbstractThe aim is to assess the outcome of external cephalic version (ECV) for term breech in our clinical setting and the factors involved. Patients with no contraindications and who consented to ECV were recruited into this prospective study. Terbutalin infusion was used. There were 42 ECV attempts of which 21 (50%) were successful. Seventeen of the patients with successful ECV delivered vaginally and 4 had cesarean section for various indications. Only 5 of the 21 unsuccessful ECV delivered vaginally. Thirteen had elective cesarean section and 2 had emergency cesarean during trial of breech. One patient from the unsuccessful ECV group was lost to follow‐up. There were 31 (74%) primipara. The birth weight of the babies was not a significant factor in the outcome of ECV. The type of breech and parity did influence the success rate. External cephalic version should be included in the routine management of our breech presentation.
A Multicentre Study to Investigate the Prevalence of Abnormal Carbohydrate Metabolism in Chinese Pregnant Women
Authors: Lee C. P. , Wang Z. Q. , Duthie S. J. , Ma H. K. , Zhang J. Z. , Zhou S. M. , Li D. F. H. 
Published: August 2010

AbstractObjectives: To determine the prevalence of abnormal carbohydrate metabolism in Chinese pregnant women. To study the inter‐relationship between maternal body habitus, maternal serum glucose and birth weight of the baby.Methods: Multicentre observational study involving 713 pregnant Chinese women, attending antenatal clinics in Beijing, Shanghai, Guangzhou and Hong Kong.Results and Conclusion: The overall prevalence of abnormal glucose tolerance was 6.9%. The prevalence was 6.8%, 5.5%, 7.2% and 8.1% in Beijing, Shanghai, Guangzhou and Hong Kong, respectively. The differences among the centres did not reach statistical significance (p = 0.9). The mean ponderal index of women with abnormal glucose tolerance was significantly higher than that of women with normal glucose tolerance (15.2 vs 14.3, p < 0.01). The birth weight ratio of the babies was positively correlated with the maternal height (correlation coefficient 0.23, 95% C.I. 0.15–0.30), weight (0.32, 95% C.I. 0.25–0.39) and to a lesser extent, the fasting level of serum glucose (0.10, 95% C.I. 0.02–0.28) but not with the 2 hour level of serum glucose.
Absence of Vagina and Hypoplasia of the Urethra and Ectopia of the Ureter
Authors: Nasu Kaei , Yoshimatsu Jun , Miyakawa Isao , Nakagawa Masahisa , Nomura Yoshio 
Published: August 2010

AbstractA 16‐year‐old Japanese girl was admitted for evaluation of complaints of primary amenorrhea, cyclic lower abdominal pain, and urinary incontinence. Her vaginal introitus appeared rudimentary with a depth of 0.5 cm and hypoplasia of the hymenal ring. A hypoplastic urethra (diameter: 1 cm; length: 0.5 cm) and 1 of 2 right ectopic ureters opened into the introitus. Transabdominal ultrasonography demonstrated fluid distending the uterus, the proximal 1/3 of the vagina, and the pouch of Douglas. Computed tomography (CT) and magnetic resonance imaging (MRI) confirmed the presence of hematometrocolpos and fluid collection in the pouch of Douglas. These associated anomalies can be due to faulty growth of the urogenital sinus. In addition to the transabdominal ultrasonography and CT, MRI was useful in the diagnosis and evaluation of vaginal agenesis.
Mucinous Cystadenocarcinoma with Sarcoma‐like Mural Nodules Arising in a Mature Cystic Teratoma of the Ovary: A Case Report
Authors: Mizuno Kaoruko , Hirata Shuji , Kasai Tsuyoshi , Yasumizu Takehiko , Kato Junzo 
Published: August 2010

AbstractAlmost all cases with malignant transformation of a mature cystic teratoma of the ovary have been reported to be associated with squamous cell carcinoma. We describe a very rare case of mucinous cystadenocarcinoma with sarcoma‐like mural nodules arising in an ovarian teratoma.
A Method of Measuring Dipalmitoylphosphatidylcholine (DPPC) by High‐Performance Liquid Chromatography (HPLC): Effect of Dexamethasone on DPPC Secretion in Fetal Rat Alveolar Type II Cell Culture*
Authors: Suzuki Rika , Ichikawa Fumitaka , Endo Chikara , Hoshi Kazuhiko , Sato Akira 
Published: August 2010

AbstractObjectives: To establish a method by which to measure dipalmitoylphosphati‐dylcholine (DPPC), which is the most prevalent phospholipid in lung surfactant, by high‐performance liquid chromatography (HPLC), and to measure DPPC secretion in type‐II alveolar cell culture to determine whether glucocorticoid has a direct accerelating effect.Method: Type‐II alveolar cell suspensions were made with fetal rat lungs and then cultured. Dexamethasone (10‐9, 10‐8 M) was added to some of the culture dishes. DPPC was extracted from the culture medium, purified, and measured by high‐performance liquid chromatography (HPLC).Results: In the measurements of DPPC, the specificity of isolation and measurement parity were excellent [coefficient of variation: intraassay; 5.66% (0.005 mg/ ml), 25.37% (0.05 mg/ml)): interassay; 8.35% (0.005 mg/ml)), 0.08% (0.05 mg/ml))]. The DPPC concentration in the culture dishes of the dexamethasone was not significantly different than that of the control dishes (Student's t)‐test).Conclusion: The above results prove that dexamethasone does not directly stimulate lung alveolar type‐II cells.
Doppler‐Velocity Waveforms in Ductus Venosus in Normal and Small‐for‐Gestational‐Age Fetuses
Authors: Nakata Masahiko 
Published: August 2010

AbstractObjective: To investigate blood‐flow patterns in ductus venosus in growth‐retarded fetuses.Methods: Reference ranges of ductus venosus flow velocities were constructed from a cross‐sectional study of 179 normal fetuses between 16 to 38 weeks' gestation, and the ductus venosus flow‐velocity waveforms in 11 small‐for‐gestational‐age (SGA) fetuses were compared with normal patterns.Results: Of 179 pregnant women who were possible subjects, 175 were employed for the analysis, and ductus venosus flow‐velocity waveforms were obtained in 197 out of 211 examinations (success rate = 93.4%). The peak forward velocities during (a) ventricular systoles, (b) the lowest forward velocities during atrial contractions, and (c) the time‐averaged velocities all linearly increased as gestational ages increased [respectively: (a) slope, 1.135; constant, 31.720; (b) slope, 1.154; constant, 1.557; (c) slope, 1.240; constant, 19.386]. Peak forward velocities during ventricular systoles and time‐averaged velocities in the SGA group did not differ from those of the normal group. Three SGA fetuses with abnormal flow in the umbilical artery showed a marked reduction of the lowest velocities during atrial contractions in the ductus venosus, and two of them showed no forward velocity at all.Conclusion: The Doppler‐velocity waveforms of ductus venosus showed a marked reduction of the end diastolic flow, especially in SGA fetuses with abnormal umbilical artery flows.
Chromosomal Analysis in 894 Induced Abortuses from Women of Advanced Maternal Age in Relation to Gestational Weeks and Fetal Sex Ratio
Authors: Hoshi Nobuhiko , Hanatani Kaoru , Kishida Tatsuro , Sagawa Tadashi , Fujimoto Seiichiro 
Published: August 2010

AbstractObjective: To clarify the prenatal sex ratio, and types and frequencies of chromosome anomalies in relation to gestational weeks in women of advanced maternal age.Methods: Chromosomal analysis was performed in 894 induced abortuses derived from elderly pregnant women 35 or more years of age.Results: The embryonic sex ratio in the chromosomally normal (abnormal) gave a preponderance of females over males in lower gestational weeks [366/458 (63/73); 79.9 to 100 (86.3 to 100) in 4–10 weeks]; the reversal of dominancy in those from females to males occurred in the 11th gestational week [41/29(5/4); 141.4 to 100 (125.0 to 100) in 11–20 weeks]. The frequency of trisomy in females at 10 weeks of gestation was significantly high (7/28; 25%).Conclusions: This study showed that the existence of a difference of and a reversal of the sex ratio in gestational weeks. It was considered that there might be a lower viability of genetically handicapped males as compared to such females. However, the reversal of the sex ratio, such as that observed between 9th and 10th gestational weeks, might reflect events occurring after implantation.
An Interesting Unusual Case of Endometrial Stromal Sarcoma
Authors: Mittal Suneeta , Sharma Rohit , Kriplani Alka , Buckshee Kamal 
Published: August 2010

AbstractAn interesting case with an unusual presentation of endometrial sarcoma is described. This patient presented with a history of continuous vaginal bleeding 3 months following a full term caesarean section and perception of an enlarging abdominal mass. The physical examination revealed an enlarged uterus with a leiomyoma though there was no evidence of the same at the time of the caesarean section. A laparotomy was undertaken and the patient was found to have a large tumor with multiple polypoidal growths invading the myometrium through to the serosa. This was proven to be an endometrial stromal sarcoma on histopathology.
Amniotic Fluid Volume in Spurious Labour
Authors: Biswas Arijit , Chew Stephen C. L. , Anandakumar Chinnaya , Chua Selina P. K. , Arulkumaran Sabaratnam 
Published: August 2010

AbstractObjective: A prospective study was undertaken to assess the amniotic fluid index (AFI) in women with spurious labour and its possible role in management.Methods: Eight hundred and ninety‐three women in early labour, who had uncomplicated pregnancy, were recruited for the study. Of these, 133 were later diagnosed to have had spurious labour, while 760 were in true labour. An admission cardiotocography and determination of AFI was done for all patients at the time of their admission to the labour ward. Labour was induced within 24 hours for those women in spurious labour who had severe oligohydramnios.Results: The incidence of severe oligohydramnios (AFI < 5) was significantly higher in the patients later diagnosed to have had spurious labour (15.7%) compared with those in true labour (2.1%). With this management protocol, the obstetric and the neonatal outcome was similar in the spurious labour and the true labour groups.Conclusion: The assessment of AFI could be a simple and useful screening tool to avoid adverse perinatal outcome in women who experience spurious labour.
Effects of Hormone Replacement Therapy on Sexuality in Postmenopausal Women in a Mideast Country
Authors: Omu Alexander E. , Al‐Qattan Najeeba 
Published: August 2010

AbstractObjective: During the postmenopausal period, sexual interest and activity seem to decline, as part of the menopausal effect of oestrogen deficiency. The aim of this study was to evaluate other factors that could contribute to sexual dysfunction and the effect of hormone replacement therapy among postmenopausal women in Kuwait.Method: Between June 1992, and June 1994, details of sexual history were compiled from 261 postmenopausal women that attended the Menopause Clinic at the Maternity Hospital, Kuwait. The effect of hormone replacement was analysed from the sexual history and the bacteriology of the lower genital tract.Results: About 71% of the 261 postmenopausal women were still sexually active. Among those not sexually active, 38% had loss of interest, 22% because of divorce or death of husband, 20% from loss of interest by husband, and in 13% because the husbands had impotence from medical problems. Of the sexually active women, 41.1% had reduced libido. Contributing factors included vaginal symptoms like dyspareunia and vaginal dryness, vaginal infection, disturbances in the premenopausal menstrual pattern and disharmony with husbands. About 23 to 45% of the postmenopausal women with oestrogen replacement therapy, had significant relief of their symptoms of sexual dysfunction. Vasomotor symptoms had better response compared to sexual dysfunction (p < 0.01). Natural oestrogen gave slightly better relief of symptoms of sexual dysfunction than other forms of oestrogen therapy. Livial gave complete relief of dyspareunia and vaginal dryness in 9.1% and 3.9% respectively, but none of those with libido and vaginal discharge had any relief.Conclusion: There is a decline in sexual response and activity in postmenopausal women in Kuwait. This is however, multifactorial in origin. Although oestrogen replacement therapy gives significant relief in symptoms of sexual dysfunction, other contributory factors should always be evaluated.
The Effect of Prolonged Cycles of Chemotherapy on Quality of Life in Gynaecologic Cancer Patients
Authors: Carter Jonathan R. , Chen M. Dwight , Fowler Jeffrey M. , Carson Linda F. , Twiggs Leo B. 
Published: August 2010

AbstractObjective: The aim of this study was to determine if the prescription of prolonged cycles of chemotherapy to patients with a variety of gynaecologic cancers has an adverse effect on quality of life (QOL).Methods: Patients attending a single gynaecologic oncology clinic who received greater than 6 cycles of chemotherapy were identified. Prior to each chemotherapy cycle, patients were asked to complete a modified Functional Assessment Cancer Therapy‐General (FACT‐G) quality of life form. QOL scores were compared to their baseline or pretreatment score (cycle 1 score), as well as to their score representing the completion of primary therapy (cycle 6 score).Results: Seventeen patients were identified as having received greater than 6 cycles of systemic cytotoxic chemotherapy. The total number of chemotherapy cycles analyzed was 95. Comparing QOL scores for cycle 1 and 6 to cycles 7–16, we found no significant alteration (improvement or deterioration) in the following subscale scores: physical well being (PWB), social well being (SWB), and functional well being (FWB). Similarly, overall QOL as represented by the summed individual scores was also not affected by the prescription of up to 16 cycles of chemotherapy. Analysis of the emotional well being (EWB) subscale scores revealed a significant downward trend after the 12th cycle of therapy as compared to the 6th cycle (p = 0.04), however this trend was not significant when compared to the pretreatment or cycle 1 scores (p = 0. 16). There was however a statistically significant progressive deterioration in the subscale score of the relationship with the doctor (RWD). This was most marked after the 10th cycle of therapy (p < 0.0001). When split by disease status, we again found no statistically significant alteration in PWB, SWB, RWD, EWB, FWB and overall QOL for cycle 1 and 6 as compared to cycles 7–17. However, those patients who were able to attain a complete clinical response (CCR) disease status, achieved a higher SWB (p = 0.003), RWD (p = 0.02), EWB (p = 0.03), and overall QOL scores (p = 0.04) while their PWB scores were not statistically different from patients with stable (p = 0.7) or progressive disease (p = 0.6).Conclusion: In conclusion, the prescription of prolonged cycles of chemotherapy to patients with gynaecologic cancers does not result in an overall deterioration of QOL. Further more an improvement in subscale and overall QOL was demonstrated in those patients able to attain a complete clinical response (CCR).
Pheochromocytoma during Pregnancy: Case Report
Authors: Chittacharoen Apichart , Phuapradit Winit 
Published: August 2010

AbstractPheochromocytoma during pregnancy is rare. Only a few hundred cases have been published in the literature. We report patients with pheochromocytoma diagnosed at antepartum period. Manifestation include hypertension with various clinical presentation, possibly resembling those of pregnancy‐induced hypertension. Confirmation necessitates special biochemical examination and the use of different radiological imaging tool. Treatment combines medical procedures with surgical exploration, mandating a team approach of diverse medical expertise. In the first and second trimesters, tumor resection has a good fetal outcome; in later pregnancy, delivery by elective cesarean section followed by tumor resection is recommended. The overall prognosis is mainly affected early diagnosis and multidisciplinarian management.
Effect of Maternal Exercise on Fetal Umbilical Artery Waveforms: The Comparison of IUGR and AFD Fetuses
Authors: Nabeshima Yuichi , Sasaki Junichi , Mesaki Noboru , Sohda Satoshi , Kubo Takeshi 
Published: August 2010

AbstractObjective: To determine the effect of maternal exercise on the fetal blood flow of normal and growth‐retarded fetuses.Methods: The effect of maternal exercise on fetal blood flow was investigated with 24 pregnant women between 36 and 42 weeks' gestation. Seventeen pregnancies were uncomplicated (normal group) and the other 7 were complicated with growth‐retarded fetuses (IUGR group). They underwent graded walking on a treadmill with an upper limit of 150 bpm for the maternal heart rate. The systolic over diastolic velocity ratio (S/D ratio) of the umbilical artery was measured before exercise, and at 3, 5, 10, and 15 minutes after exercise.Results: The mean S/D ratio of the IUGR group before exercise was significantly higher than that of the normal group (p < 0.05). The S/D ratio did not change significantly after exercise, in either the normal group or the IUGR group.Conclusion: This study suggests that maternal exercise at this level of intensity and duration does not have any harmful effect, even on growth‐retarded fetuses that might have placental dysfunctions.
DNA Analysis of the Androgen Receptor Gene in Two Cases with Complete Androgen Insensitivity Syndrome
Authors: Komori Shinji , Sakata Kazuko , Tanaka Hiroyuki , Shima Hiroki , Koyama Koji 
Published: August 2010

AbstractObjective: Androgen insensitivity syndrome is an X‐linked disorder of sexual differentiation resulting from abnormalities of the androgen receptor gene. In this study, we analyzed the androgen receptor gene in 2 cases with complete androgen insensitivity syndrome (CAIS).Methods: DNAs were isolated from patients with CAIS, and the androgen receptor gene was amplified by a polymerase chain reaction. Sequence analysis of the androgen receptor gene was performed.Results: In Patient 1, one substitutional mutation [glutamine (CAA) to arginine (CGA) at position 194] was identified in exon A, and the premature termination of the androgen receptor gene was also demonstrated due to the deletion of one nucleotide at the codon in exon C (position 597). In Patient 2, one substitutional mutation [arginine (CGC) to cysteine (TGC) at position 855] in exon G was identified. This position was located in the hormone‐binding domain and appeared to be a hot spot of mutations because the mutations at the same position have been reported before in several unrelated cases.Conclusion: The results of this study suggest that these abnormalities might be related to the pathogenesis of complete androgen insensitivity syndrome.
Hypertension in Pregnancy: A Study of the Asia‐Oceania Region
Authors: Spurrett Brian R. , Cook Colleen‐M. 
Published: August 2010

AbstractA review of the management practices and problems surrounding hypertension in pregnancy in the Asia‐Oceania region was made. This review was achieved by surveying institutions in the region. Sixteen countries responded to this survey and the results were analysed. Both rural and city hospitals were involved in the survey. The centres were selected by members of the Maternal Perinatal Committee of the Asia‐Oceania Federation of Obstetrics and Gynaecology (AOFOG) under whose patronage the survey was performed.Analysis of the survey revealed a number of problems which could be addressed by appropriate educational interventions, these included drug therapies and protocols, deficiencies in governmental support especially in transport and centralised intensive care facilities. Public awareness was also a priority to be addressed.The role of the traditional birth attendant has been increasingly recognised as a resource which could be utilised. This is highlighted in this survey where there are countries who will be dependant on these carers for the next 10 years at least. Their place in the management of hypertension is discussed.