bluuebunny/crossref_metadata_2025_split huggingface dataset:
The dynamic nitric oxide pattern in developing cuttlefish Sepia officinalis
Authors: Mattiello Teresa , Costantini Maria , Di Matteo Bruna , Livigni Sonia , Andouche Aude , Bonnaud Laure , Palumbo Anna 
Published: December 2011

AbstractBackground: Nitric oxide (NO) is implied in many important biological processes in all metazoans from porifera to chordates. In the cuttlefish Sepia officinalis NO plays a key role in the defense system and neurotransmission. Results: Here, we detected for the first time NO, NO synthase (NOS) and transcript levels during the development of S. officinalis. The spatial pattern of NO and NOS is very dynamic, it begins during organogenesis in ganglia and epithelial tissues, as well as in sensory cells. At later stages, NO and NOS appear in organs and/or structures, including Hoyle organ, gills and suckers. Temporal expression of NOS, followed by real‐time PCR, changes during development reaching the maximum level of expression at stage 26. Conclusions: Overall these data suggest the involvement of NO during cuttlefish development in different fundamental processes, such as differentiation of neural and nonneural structures, ciliary beating, sensory cell maintaining, and organ functioning. Developmental Dynamics 241:390–402, 2012. © 2011 Wiley Periodicals, Inc.
Involving the Public in Catchment Management: An Analysis of the Scope for Learning Lessons from Abroad
Authors: Benson David , Jordan Andrew , Huitema Dave 
Published: December 2011

ABSTRACTScholars have tended to treat the European Union (EU) as an environmental ‘leader’. Yet significant potential nonetheless exists for it to learn lessons in areas such as water policy where it has a long and successful history of involvement. The EU's Water Framework Directive (2000) imposes potentially far reaching requirements on its Member States to enhance public participation in the process of catchment management. However, to date, its implementation has been highly variable across and even within individual states. As the EU starts to revise the original Directive, thoughts will turn to how the current situation could be improved. One potentially productive avenue, which has not yet been fully explored, is to draw lessons on public participation from comparable multi‐levelled governance contexts such as in the USA and Australia, where public engagement has arguably been more advanced. Drawing on theoretical accounts of the most likely facilitators and obstacles to lesson drawing, this paper assesses the scope for transfer. It finds that while the EU could potentially learn from these jurisdictions, there are likely to be significant obstacles in practice. These should be born in mind by would‐be policy learners. Copyright © 2011 John Wiley & Sons, Ltd and ERP Environment.
Macrophages participate in IL‐17‐mediated inflammation
Authors: Barin Jobert G. , Baldeviano G. Christian , Talor Monica V. , Wu Lei , Ong SuFey , Quader Farhan , Chen Ping , Zheng Dongfeng , Caturegli Patrizio , Rose Noel R. , C̆iháková Daniela 
Published: December 2011

AbstractThe involvement of macrophages (MΦs) in Th17‐cell responses is still poorly understood. While neutrophils are thought to be the predominant effector of Th17‐cell responses, IL‐17 is also known to induce myelotropic chemokines and growth factors. Other T‐cell‐derived cytokines induce non‐classical functions, suggesting that IL‐17 sigxnaling may similarly elicit unique MΦ functions. Here, we characterized the expression of subunits of the IL‐17 receptor on primary murine MΦs from different anatomical compartments. The greatest expression of IL‐17 receptors was observed on mucosal Ly6Chi "inflammatory" MΦs. We further observed upregulation of IL‐17 receptors in vitro on bone marrow‐derived macrophages (BMMΦs) in response to peptidoglycan or CpG oligonucleotide stimuli, and in vivo, upon CFA administration. Macrophages expressing IL‐17 receptors were observed infiltrating the hearts of mice with myocarditis, and genetic ablation of IL‐17RA altered MΦ recruitment. Treating primary MΦs from a wide variety of different anatomic sources (as well as cell lines) with IL‐17A induced the production of unique profiles of cytokines and chemokines, including GM‐CSF, IL‐3, IL‐9, CCL4/MIP‐1β and CCL5/RANTES. IL‐17A also induced production of IL‐12p70; IL‐17‐signaling‐deficient MΦs elicited diminished IFN‐γ production by responding DO11.10 CD4+ T cells when used as APCs. These data indicate that MΦs from different anatomic locations direct IL‐17‐mediated responses.
Experimental and Theoretical Studies of Unusual Four‐Membered Metallacycles from Reactions of Group 4 Metallocene Bis(trimethylsilyl)acetylene Complexes with the Sulfurdiimide Me3SiN=S=NSiMe3
Authors: Kaleta Katharina , Ruhmann Martin , Theilmann Oliver , Roy Subhendu , Beweries Torsten , Arndt Perdita , Villinger Alexander , Jemmis Eluvathingal D. , Schulz Axel , Rosenthal Uwe 
Published: December 2011

AbstractThe use of the sulfurdiimide RN=S=NR′ (R = R′ = SiMe3, 3) in reactions with group 4 metallocene bis(trimethylsilyl)acetylene complexes of the type [Cp2M(L)(η2‐Me3SiC2SiMe3)] (1: M = Ti, no L; 2: M = Zr, L = pyridine) has led to the formation of four‐membered metallacycles 4M containing the group 4 metal, nitrogen and sulfur. DFT calculations performed on compound 4Ti indicate that this complex is best described as a σ‐complex with cyclic delocalisation of the ring electrons. Moreover, pseudo‐Jahn–Teller distortion plays a significant role in stabilising this complex.
Virgin rapeseed oils obtained from different rape varieties by cold pressed method – their characteristics, properties, and differences
Authors: Tynek Maria , Pawłowicz Roman , Gromadzka Justyna , Tylingo Robert , Wardencki Waldemar , Karlovits Gyorgy 
Published: December 2011

AbstractThe aim of the present study was to compare different rape varieties. For this purpose oil from six different varieties of rapeseeds was cold pressed under laboratory conditions. In the obtained rapeseed oils the fatty acids composition and minor components, characteristic values (acid value; AV and TOTOX), oxidative stability (DSC test), and volatiles were determined and a sensory evaluation was carried out. The highest oxidative stability was found for oil from sample 5 (IP = 158 min), which also has the lowest amount of C18:3 (7.8%), chlorophylls (0.083 mg/kg), and metals (Cu2+ 0.02 mg/kg and Fe2+ 0.08 mg/kg). This oil has also the lowest AV (0.17 mg KOH/g), which may be related to the lowest moisture content of the seeds prior to extraction. It was characterized by the highest rapeseed flavor intensity. The lowest induction period was observed for samples 3 and 6 (100 min). Although sample 3 had the same low level of metals as sample 5 and the highest concentration of tocopherols (635 mg/kg), PUFA (33.9%), and AV (1.37 mg KOH/g) it also had the lowest intensity of rapeseed flavor among the analyzed oils. Sample 6, despite its low percentage of PUFA (24.7%), conjugated diens and triens, and the lowest content of total volatiles (0.4Vs), had the highest concentration of metals (Cu2+ 0.04 mg/kg and Fe2+ 0.34 mg/kg).
A finite element variational multiscale method for incompressible flows based on the construction of the projection basis functions
Authors: Yu Jiaping , Zheng Haibiao , Shi Feng 
Published: December 2011

SUMMARYIn this article, we present a finite element variational multiscale (VMS) method for incompressible flows based on the construction of projection basis functions and compare it with common VMS method, which is defined by a low‐order finite element space Lh on the same grid as Xh for the velocity deformation tensor and a stabilization parameter α. The best algorithmic feature of our method is to construct the projection basis functions at the element level with minimal additional cost to replace the global projection operator.Finally, we give some numerical simulations of the nonlinear flow problems to show good stability and accuracy properties of the method. Copyright © 2011 John Wiley & Sons, Ltd.
The Effect of 80 dB Environmental Noise on Control of Posture in Healthy Young Adults
Authors: Bateni H. , Vaizasatya A. , Blaschak M. J. 
Published: December 2011

AbstractThe ability to control movement of the center of mass (COM) plays a vital role in control of posture. Traditionally, visual, vestibular, and somatosensory systems are considered sources of information provided to the central nervous system to control posture. Recently, other environmental stimuli that can indirectly affect postural control have been taken into consideration. One in particular is excessive environmental noise that may exist in some working conditions (e.g., construction sites, assembly lines, food‐processing plants). We examined postural performance of 16 healthy young adults (21 to 26 years old) while being exposed to a computer‐generated 80‐dB intermittent white noise. Participants were tested for their ability to keep their COM static in three conditions of eyes open‐static platform (SEO), eyes closed‐static platform (SEC), and eyes open‐dynamic platform (DYN). Their limits of stability (LOS) also were tested to identify their ability to shift their COM to the borders of an area representing 50% of their base of support. Our results indicated that white noise at the level of 80 dB does not influence either the ability to hold the COM static or the precision to shift COM toward the borders of the base of support. We concluded that environmental noise at the level of 80 dB does not have a short‐term effect on postural control in a normal standing posture. © 2011 Wiley Periodicals, Inc.
Coordination and Task Interdependence during Schedule Adaptation
Authors: de Snoo Cees , van Wezel Wout 
Published: December 2011

AbstractThis article discusses the influence of organizational and behavioral variables on coordination between planners during plan adaptation. Fast communication and mutual alignment are necessary to maintain schedule feasibility in a situation with several schedulers. Therefore, coordination modes are required that facilitate communication and joint problem solving. Moreover, building on interdependence theory, we hypothesize that the schedulers' perceptions of task interdependence influence rescheduling performance. Experimental results indicate that a group decision‐making coordination mode enforcing cooperation outperforms a distributed decision‐making coordination mode involving emergent alignment. The level of perceived task interdependence explains this better performance. Therefore, perceptions of task interdependence are put forward as an important behavioral factor influencing rescheduling performance, with several important implications for theory and practice. © 2011 Wiley Periodicals, Inc.
Calibration of hydrological models in ungauged basins based on satellite radar altimetry observations of river water level
Authors: Sun Wenchao , Ishidaira Hiroshi , Bastola Satish 
Published: December 2011

ABSTRACTThis paper proposes a new orientation to address the problem of hydrological model calibration in ungauged basin. Satellite radar altimetric observations of river water level at basin outlet are used to calibrate the model, as a surrogate of streamflow data. To shift the calibration objective, the hydrological model is coupled with a hydraulic model describing the relation between streamflow and water stage. The methodology is illustrated by a case study in the Upper Mississippi Basin using TOPEX/Poseidon (T/P) satellite data. The generalized likelihood uncertainty estimation (GLUE) is employed for model calibration and uncertainty analysis. We found that even without any streamflow information for regulating model behavior, the calibrated hydrological model can make fairly reasonable streamflow estimation. In order to illustrate the degree of additional uncertainty associated with shifting calibration objective and identifying its sources, the posterior distributions of hydrological parameters derived from calibration based on T/P data, streamflow data and T/P data with fixed hydraulic parameters are compared. The results show that the main source is the model parameter uncertainty. And the contribution of remote sensing data uncertainty is minor. Furthermore, the influence of removing high error satellite observations on streamflow estimation is also examined. Under the precondition of sufficient temporal coverage of calibration data, such data screening can eliminate some unrealistic parameter sets from the behavioral group. The study contributes to improve streamflow estimation in ungauged basin and evaluate the value of remote sensing in hydrological modeling. Copyright © 2011 John Wiley & Sons, Ltd.
Cadmium a metalloestrogen: are we convinced?
Authors: Silva Nalinda , Peiris‐John Roshini , Wickremasinghe Rajitha , Senanayake Hemantha , Sathiakumar Nalini 
Published: December 2011

ABSTRACTMetalloestrogens are inorganic metal ions that bind to and activate oestrogen receptors. They are implicated in the aetiology of oestrogen‐dependent diseases such as cancers of the breast and endometrium as well as endometriosis. Cadmium is one of the most studied metalloestrogens. In this review, scientific evidence for the oestrogenic effects of cadmium is critically evaluated to determine if there is sufficient evidence to support cadmium as an aetiological factor of oestrogen‐dependent disease in humans. Results of the review indicated that, although the in vitro and in vivo evidence of the oestrogenic properties of cadmium was persuasive, evidence from population‐based human studies remains conflicting. Considerable knowledge gaps exist on the potential oestrogenic effect of cadmium in humans. Research that focuses on bridging these knowledge gaps would be useful in preventing and managing oestrogen‐dependent disease in humans. Copyright © 2011 John Wiley & Sons, Ltd.
Collagen‐immobilized patch for repairing small tympanic membrane perforations: In vitro and in vivo assays
Authors: Farhadi Mohammad , Mirzadeh Hamid , Solouk Atefeh , Asghari Alimohamad , Jalessi Maryam , Ghanbari Hadi , Yazdanifard Parin 
Published: December 2011

AbstractTympanic membrane (TM) perforation is still one of the most common otology complications. New designs of biomaterials, and lately tissue‐engineered composites and grafts, have thoroughly revolutionized the management of TM perforation. In this study, we examined a biologically modified collagen‐immobilized polydimethyl siloxane patch to repair TM perforation. In vitro potential of the aforementioned patch as a scaffold to support fibroblast cell growth and adhesion was assessed. An in vivo assay of the patch for initiating repair of TM perforations also was investigated. In vitro assay showed that the patch has significantly increased cell adhesion and growth in comparison with unmodified ones (p < 0.05). In vivo study also showed an overall closure rate of TM perforation of 70% and an average gain of 15.75 ± 4.29 dB in air‐bone gap. This study shows that the preliminary in vivo evaluation of a modified siloxane patch in humans had promising results and is comparable to existing biomaterial patches. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.
Erecting closets and outing ourselves: uncomfortable reflexivity and community‐based research
Authors: Reed Sarah J. , Miller Robin Lin , Nnawulezi Nkiru , Valenti Maria T. 
Published: December 2011

AbstractFeminist scholars and community psychologists have argued that reflexivity is a necessary component to conducting socially conscious research. Reflexivity, however, is rarely evident in community psychology. In this article, we share the uncomfortable realities that surfaced during a community‐based research project in which we adapted and implemented an HIV prevention intervention for young Black sexual minority women. We each describe how aspects of our identities, values, and socialization affected our engagement in the research and our interactions with and feelings towards participants. In doing so, we hope to call attention to the messiness of community‐based work, as well as to promote a community of scholars who are open to self‐appraisal and willing to share their least comfortable examples of conducting community‐based work in diverse communities. © 2011 Wiley Periodicals, Inc.
Grand challenge competition to predict in vivo knee loads
Authors: Fregly Benjamin J. , Besier Thor F. , Lloyd David G. , Delp Scott L. , Banks Scott A. , Pandy Marcus G. , D'Lima Darryl D. 
Published: December 2011

AbstractImpairment of the human neuromusculoskeletal system can lead to significant mobility limitations and decreased quality of life. Computational models that accurately represent the musculoskeletal systems of individual patients could be used to explore different treatment options and optimize clinical outcome. The most significant barrier to model‐based treatment design is validation of model‐based estimates of in vivo contact and muscle forces. This paper introduces an annual “Grand Challenge Competition to Predict In Vivo Knee Loads” based on a series of comprehensive publicly available in vivo data sets for evaluating musculoskeletal model predictions of contact and muscle forces in the knee. The data sets come from patients implanted with force‐measuring tibial prostheses. Following a historical review of musculoskeletal modeling methods used for estimating knee muscle and contact forces, we describe the first two data sets used for the first two competitions and summarize four subsequent data sets to be used for future competitions. These data sets include tibial contact force, video motion, ground reaction, muscle EMG, muscle strength, static and dynamic imaging, and implant geometry data. Competition participants create musculoskeletal models to predict tibial contact forces without having access to the corresponding in vivo measurements. These blinded predictions provide an unbiased evaluation of the capabilities and limitations of musculoskeletal modeling methods. The paper concludes with a discussion of how these unique data sets can be used by the musculoskeletal modeling research community to improve the estimation of in vivo muscle and contact forces and ultimately to help make musculoskeletal models clinically useful. © 2011 Orthopaedic Research Society. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 30:503–513, 2012
Synergy of tendon stem cells and platelet‐rich plasma in tendon healing
Authors: Chen Lei , Dong Shi‐Wu , Liu Jun‐Peng , Tao Xu , Tang Kang‐Lai , Xu Jian‐Zhong 
Published: December 2011

AbstractInjured rat Achilles tendons were treated with botulism toxin to create a mechanically unloaded condition (unloaded) or left untreated (loaded), and then treated with phosphate‐buffered saline (PBS), platelet‐rich plasma (PRP), tendon stem cells (TSCs), or a combination (TSCs + PRP). mRNA and protein expression of collagen I, collagen III, tenascin C, and Smad 8 were determined by real time PCR and immunostaining, respectively. Loaded tendons treated with PBS, PRP, or TSCs for 3 or 14 days had higher collagen I mRNA expression than unloaded tendons. Loaded tendons treated with PBS for 3 or 14 days or with PRP for 3 days had higher collagen I protein levels than unloaded tendons. Loaded tendons treated for 3 days with PBS, for 14 days with PRP or TSCs or TSCs + PRP for 3 or 14 days had higher collagen III protein levels than unloaded tendons. Collagen I mRNA levels were higher in TSCs + PRP‐treated loaded tendons compared to PBS‐treated loaded tendons on day 3 of treatment. Based on changes in the expression of tendon‐healing genes, our data suggest that the combination of TSCs and PRP has synergistic effects on tendon healing under both loaded and unloaded conditions, and loaded conditions improve tendon healing. © 2011 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 30:991–997, 2012
Constraining Holocene 10Be production rates in Greenland
Authors: Briner Jason P. , Young Nicolás E. , Goehring Brent M. , Schaefer Joerg M. 
Published: December 2011

AbstractThe absence of a production rate calibration experiment on Greenland has limited the ability to link 10Be exposure dating chronologies of ice‐margin change to independent records of rapid climate change. We use radiocarbon age control on Holocene glacial features near Jakobshavn Isbræ, western Greenland, to investigate 10Be production rates. The radiocarbon chronology is inconsistent with the 10Be age calculations based on the current globally averaged 10Be production rate calibration data set, but is consistent with the 10Be production rate calibration data set from north‐eastern North America, which includes a calibration site nearby on north‐eastern Baffin Island. Based on the best‐dated feature available from the Jakobshavn Isbræ forefield, we derive a 10Be production rate value of 3.98 ± 0.24 atoms g a−1, using the ‘St’ scaling scheme, which overlaps with recently published reference 10Be production rates. We suggest that these 10Be production rate data, or the very similar data from north‐eastern North America, are used on Greenland. Copyright © 2011 John Wiley & Sons, Ltd.
Optimization and validation of a fast ultrahigh‐pressure liquid chromatographic method for simultaneous determination of selected sulphonamides in water samples using a fully porous sub‐2 μm column at elevated temperature
Authors: Shaaban Heba , Górecki Tadeusz 
Published: December 2011

AbstractHigh temperature in HPLC is considered a valuable tool helping to overcome the increase in the column backpressure when using small packing particles such as sub‐2 μm, as it allows reduction in the mobile‐phase viscosity. In this study, a fast analytical method based on HPLC‐UV was developed using a sub‐2 μm column at elevated temperature for the simultaneous determination of nine sulphonamides. Owing to the lower viscosity of the mobile phase, the separation could be achieved in 3 min at 60°C for all analytes. The effect of temperature, the organic modifier percentage and the flow rate on the retention time was studied. The method developed was used for the determination of selected sulphonamides in surface and wastewater samples. Sample preparation was carried out by solid‐phase extraction on Oasis HLB cartridges. The method developed was validated based on the linearity, precision, accuracy, detection and quantification limits. The recovery ranged from 70.6 to 96 % with standard deviations not higher than 4.7%, except for sulphanilamide. Limits of detection ranged from 1 to 10 μg/L after optimization of all analytical steps. This method has the highest performance in terms of analytical speed compared with other published HPLC‐UV methods for the determination of sulphonamides in water.
Isothermal Cold‐Crystallization of PLA/PBAT Blends With and Without the Addition of Acetyl Tributyl Citrate
Authors: Quero Enic , Müller Alejandro J. , Signori Francesca , Coltelli Maria‐Beatrice , Bronco Simona 
Published: December 2011

AbstractThe isothermal cold‐crystallization kinetics of the PLA phase is studied by DSC and the crystallization from the melt by PLOM. Even though the blends exhibit two phases by SEM, several pieces of evidence indicate that partial miscibility may be present in these blends: small changes in both Tg and Tm of the PLA phase; a dependence of the spherulitic growth rate on blend composition and the oclusion of PBAT droplets inside PLA spherulites. Acetyl tributyl citrate is able to plasticize both phases in the blends, but it displays a preference to dissolve within the PBAT rich phase. There is a synergystic effect on the increase in the overall crystallization rate of the PLA rich phase when both ATBC and PBAT are present in the blend.