bluuebunny/crossref_metadata_2025_split huggingface dataset:
Markers of Thrombosis and Hemostasis in Acute Coronary Syndromes: Relationship to Increased Heart Rate and Reduced Heart‐Rate Variability
Authors: Hamaad Ali , Sosin Michael D. , Blann Andrew D. , Lip Gregory Y. H. , MacFadyen Robert J. 
Published: April 2009

AbstractBackgroundAcute coronary syndromes (ACS) are characterized by abnormal heart‐rate variability (HRV) and biomarkers of endothelial damage and thrombosis.HypothesisWe hypothesized an association between these factors in patients with ACS.MethodsWe studied 99 patients with ACS measuring HRV and plasma markers of endothelial damage/dysfunction (von Willebrand factor, vWF) and thrombosis/hemostasis (soluble P‐selectin (s‐Psel); CD40‐ligand (CD40‐L); D‐dimer). HRV and plasma indices were compared to age‐ and gender‐matched controls. Measures were repeated at 4 months in a subset. vWF, s‐Psel and D‐Dimer levels were raised compared to control.ResultsHRV indices were reduced (mean RR, SDNN, SDNNi, RMSSD, Triangular index, LF and HF). There were weak correlations between mean RR and s‐Psel (R = − 0.234, p = 0.023) and D‐dimer (R = − 0.219, p = 0.041). At 4‐month follow‐up, significant correlations were between mean RR and CD40L (R = − 0.414, p = 0.008) and D‐dimer (R = − 0.363, p = 0.012). On multivariate logistic regression analysis statin use (p = 0.046) was the only independent predictor of acute s‐Psel levels. Age (p = 0.004) and mean RR interval (p = 0.01) were independent predictors of D‐dimer levels at follow‐up.ConclusionsAbnormal HRV is associated with markers of hemostasis and thrombosis in ACS, and present both in the acute and rehabilitation phases. Copyright © 2009 Wiley Periodicals, Inc.
Interatrial Block: Correlation with P‐Terminal Force
Authors: Spodick David H. , Ariyarajah Vignendra , Goldberg Robert 
Published: April 2009

AbstractBackground and HypothesisInteratrial block (IAB: P‐duration > 100 ms) is poorly recognized in hospital populations. In addition to reduced left atrial function and left atrial enlargement it predicts atrial fibrillation and other arrthymias. P‐terminal force (Ptf): ± biphasic P in lead V1 ≥ area of 1 small square on the electrocardiogram (ECG) grid also indicates left atrial abnormality, particularly left atrial enlargement. These 2 should be related. We determined the intercorrelation.Methods and ResultsTwo blinded observers evaluated 500 consecutive patients' ECGs for both Ptf and IAB utilizing all 12 leads for IAB and V1 for Ptf. Measurement differences were resolved in a consensus conference. Among 482 usable ECGs, IAB and Ptf were strongly and significantly correlated (χ2 = 68.041; P≤.001).ConclusionIAB and Ptf are significantly and strongly correlated and one should be expected in the majority of cases when the other is recognized. Copyright © 2009 Wiley Periodicals, Inc.
The Importance of Gamma‐Glutamyltransferase Activity in Patients with Coronary Artery Disease
Authors: Demircan Sabri , Yazici Mustafa , Durna Kenan , Kilicaslan Fethi , Demir Serdar , Pinar Mesut , Gulel Okan 
Published: April 2009

AbstractBackgroundIn this study, we sought to investigate the relation of gamma‐glutamyltransferase (GGT) levels with the significance of coronary artery disease (CAD), clinical presentation, left ventricular (LV) function, and inflammatory activity.MethodsA total of 235 patients (mean age: 60.1 ± 10.5 years, 166 [70%] males) who had coronary angiography were included in the study. Patients who had CAD constituted the study group (Group 1, n=189) and patients who had insignificant coronary disease or normal coronary activity constituted the control group (Group 2, n=46).ResultsGGT levels were higher in Group 1 than Group 2 (38.7 ± 30.9 U/L versus 27.5 ± 17.5 U/L, p =0.025). Left ventricular ejection fraction (LVEF) was lower in Group 1 than Group 2 (52.6% ± 11.7% versus 58.8% ± 11.3%, p < 0.002). GGT activity (40.2 ± 32.5 U/L versus 29.1 ± 18.3 U/L, p < 0.002) and c‐reactive protein (CRP) levels (33.9 ± 43.6 mg/dl versus 17.8 ± 29.8 mg/dl, p < 0.002) were higher, LVEF (52.6% ± 12.1% versus 56.5% ± 11.0%, p =0.021) was lower in patients with acute coronary syndrome compared with stable CAD group. In regression analysis, CRP levels (p < 0.0001, odds ratio [OR]=3.77, 95% confidence interval [CI] 0.10 < OR < 0.32), LVEF (p =0.016, OR=− 2.44, 95% CI − 0.95 < OR < − 0.10) and LV end‐diastolic pressure (p =0.015, OR=4.31, 95% CI − 1.19 < OR < − 0.13) were independent predictors of GGT activity.ConclusionsThe increased GGT activity is related to LV function, clinical stability, and inflammatory activity rather than the severity of CAD. Measurement of GGT activity may be useful in predicting cardiovascular risk. Copyright © 2009 Wiley Periodicals, Inc.
Cutting Balloon Angioplasty and Stent Implantation for Aorto‐ostial Lesions: Clinical Outcome and 1‐year Follow‐up
Authors: Nassar Hisham , Gotsman Israel , Gerganski Penko , Moseri Morris , Lotan Chaim , Gotsman Mervyn 
Published: April 2009

AbstractBackgroundPercutaneous interventions for aorto‐ostial narrowing of native coronary arteries are challenging because of early elastic recoil after the procedure and the high restenosis rate. Cutting balloon angioplasty may reduce this complication.HypothesisThe purpose of the study was to evaluate the clinical outcomes of cutting balloon angioplasty and stent implantation for aorto‐ostial lesions with a 1‐year clinical follow‐up.MethodsAll patients with aorto‐ostial lesions in our laboratory underwent cutting balloon angioplasty and were followed for approximately 1 year.ResultsForty‐eight patients underwent balloon angioplasty; 36 of whom had lesions in the ostial right coronary artery, and 12 of whom had lesions in the left main coronary artery (LMCA). Thirty‐five patients (73%) had a stent implanted. Procedural success was achieved in all patients. The in‐hospital rate of major adverse cardiac events (MACEs) was 2.1% because of the death of 1 patient following urgent bypass surgery. Mean clinical follow‐up was 11.6 ± 7 month. Twelve patients (27%) required repeat coronary angiography, and restenosis was found in 7 patients (16%). Six patients (13.6%) had MACEs.ConclusionsCutting balloon angioplasty in combination with bare metal stent (BMS) implantation has a good clinical outcome. This technique should be compared with implantation of drug‐eluting stents (DESs) in a controlled study. Copyright © 2009 Wiley Periodicals, Inc.
Infective Endocarditis of Unusual Location Following Surgical Correction of a Complex Congenital Heart Disease
Authors: Viana‐Tejedor Ana , Sánchez‐Recalde Angel , Oliver José , Maté Isabel , Sobrino José , Bret M. , López de Sá y Areses Esteban , Lopez Sendon Jose 
Published: April 2009

AbstractA 40‐year‐old woman from Ecuador diagnosed with a complex congenital heart disease was admitted complaining of fever chills, night sweats, and productive cough 6 months after surgical correction of the anomalies. An echocardiography showed vegetations located on the interatrial pericardium patch. To the best of our knowledge, this is the first reported case of postoperative infective endocarditis on this location. Copyright © 2009 Wiley Periodicals, Inc.
Stem Cells Improve Left Ventricular Function in Acute Myocardial Infarction
Authors: Singh Sarabjeet , Arora Rohit , Handa Kamna , Khraisat Ahmad , Nagajothi Nagapradeep , Molnar Janos , Khosla Sandeep 
Published: April 2009

AbstractBackgroundAnimal studies have suggested dramatic improvement in cardiac function after acute myocardial infarction (AMI) through regeneration of the myocardium or neovascularization by transfer of cells derived from bone marrow (BMC) generated clinical studies. Recently published small sized studies have yielded mixed results, leaving the question unanswered.HypothesisWe analyzed data from these studies in a meta‐analysis to investigate if intracoronary stem cell therapy was effective in improving cardiac function.MethodsA total of 7 randomized controlled trials meeting the inclusion criteria were identified by a systematic literature search. Primary endpoint was change in global left ventricular ejection fraction (LVEF) baseline to follow‐up (ranging between 3 to 6 months). The meta‐analysis consisted of 516 patients (BMC group, 256; control group, 260). A 2‐sided α error of less than .05 was considered to be statistically significant (P<.05).ResultsThere were no significant differences in patient characteristics between the BMC treatment and control groups at baseline. Compared to the control group, patients in the BMC treatment group had significantly greater increase in LVEF from baseline to follow‐up (mean difference: 6.108%; SE: 1.753%; 95% confidence interval [CI]: 2.672%− 9.543%; P<.001).ConclusionsThe present meta‐analysis suggests that intracoronary bone marrow stem cell infusion may be effective in improving left ventricular systolic function in patients after acute myocardial infarction. Copyright © 2009 Wiley Periodicals, Inc.
Ignition Delay for Atmospheric Pressure Microplasmas
Authors: Porteanu H. E. , Kühn S. , Gesche R. 
Published: April 2009

AbstractThe ignition process in microplasmas is characterized by time resolved microwave reflection coefficient measurements, using a specially equipped vector network analyzer. We measured the time between the switching on of the microwave power and the onset of the plasma state in air at atmospheric pressures. The delay time decreases from approx. 3 ms to 60 μ s by increasing the microwave power from values just above the ignition threshold to higher values. A simple model shows the role of the free electrons in air and of the electrodes in the ignition process (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Energy Evaluation of Mono‐Energetic Electron Beam Produced by Ellipsoid Cavity Model in the Bubble Regime
Authors: Sadighi‐Bonabi R. , Rahmatallahpor S. , Navid H. , Lotfi E. , Zobdeh P. , Reiazie Z. , Bostandoust M. , Mohamadian M. 
Published: April 2009

AbstractThe electron acceleration in the bubble regime is considered during the laser‐plasma interaction. The PIC and experimental results show that the obtained ellipsoid cavity model is more consistent than the spherical model. We prove the fields inside the cavity depend linearly on the coordinates and the spherical cavity is a special case of the ellipsoid model. The quasi mono‐energetic electrons output beam tracing the laser plasma can be more appropriately described with this model (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Mean Motion in Stochastic Plasmas With a Space‐Dependent Diffusion Coefficient
Authors: Wittkowski R. , Schelin A. B. , Spatschek K. H. 
Published: April 2009

AbstractRadial transport in the tokamap, which has been proposed as a simple model for the motion in a stochastic plasma, is investigated. A theory for previous numerical findings is presented. The new results are stimulated by the fact that the radial diffusion coefficient is space‐dependent. The space‐dependence of the transport coefficient has several interesting effects which have not been elucidated so far. Among the new findings are the analytical predictions for the scaling of the mean radial displacement with time and the relation between the Fokker‐Planck diffusion coefficient and the running diffusion coef.cient from the mean square displacement. The applicability to other systems is also discussed (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Estimates of the Radial Electric Field in Tokamak‐Like Plasmas
Authors: Ou J. 
Published: April 2009

AbstractThe radial electric field is studied in tokamak‐like plasmas using a simple one dimensional model. The simulation results show that in the core plasma region, the radial electric field generally follows the toroidal velocity term, whereas at the edge, the pressure gradient term is more significant. Simultaneously, the effect of the poloidal velocity term on the radial electric field is associated with the poloidal rotation velocity near the separatrix. In addition, the ambipolar radial electric field in the non‐ambipolar state is also discussed in this paper (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Electric Microfield Distributions in Li + Plasma With Account of the Ion Structure
Authors: Sadykova S. , Ebeling W. , Valuev I. , Sokolov I. 
Published: April 2009

AbstractThe electric microfield distributions at the location of an ion have been calculated using a coupling parameter integration technique for Li + plasma proposed by Ortner et al. [4] and Molecular Dynamics simulations. Electric microfield distributions are studied in a frame of the Hellmann‐Gurskii‐Krasko pseudopotential model, taking into account the quantum‐mechanical effects and the ion shell structure [34]. The screened Hellmann‐Gurskii‐Krasko pseudopotential taking into account not only the quantum‐mecanical effects, the ion shell structure but screening field effects has been derived by means of Bogoljubow method [40] and [42]. The screened pseudopotential is represented by a Fourier transform. For the Hellmann‐Gurskii‐Krasko pseudopotential model the results obtained for the microfield in the framework of the Ortner model are found in a good agreement with the Molecular Dynamics simulations (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Finite Instrumental Resolution Scales in Plasma Modeling
Authors: Minkova N. R. 
Published: April 2009

AbstractThe classical statistical approach is based on the assumption that coordinates of all particles are distinguishable what results in one‐particle kinetic models. By considering finite instrumental resolution scales we have to suppose that particles' coordinates are indistinguishable within a probing volume. This approach produces models based on multiparticle probability functions that are derived by integration of a probability function of total particles' system. The system is formed by separating within plasma (gas) flow a volume that is in dynamic equilibrium with surroundings. The probability function of the separated system satisfies Liouville theorem if the hypothesis of detailed dynamic equilibrium is assumed. The produced multiparticle models describe plasma flow in terms of fluctuations of macroscopic parameters. The discussed approach contributes to solution of Gibbs' paradox. It is tested by wellknown classical problems and applied to modeling of solar wind plasma expansion. The derived macroscopic parameters (density and speed) of plasma flow coincide under some assumptions with results of the two‐particle kinetic model and are consistent with observational data (in contrast, the classical one‐particle models do not provide the observed solar wind acceleration under the same assumptions). The results can be interpreted in favor of the suggested multiparticle approach (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Electrochemical Aptasensor Based on Proximity‐Dependent Surface Hybridization Assay for Protein Detection
Authors: Zhang Yan‐Li , Pang Peng‐Fei , Jiang Jian‐Hui , Shen Guo‐Li , Yu Ru‐Qin 
Published: April 2009

AbstractSensitive and selective detection of proteins is of great importance in biomedical research and clinical diagnosis. Proximity‐dependent surface hybridization assay affords a promising platform for specific and ultrasensitive electrochemical detection of proteins. An improved design of proximity‐dependent surface hybridization assay is developed. A pair of aptamer probes that recognize different sites of target platelet‐derived growth factor protein (PDGF) are designed with a short complementary sequences. Simultaneous recognition of a single PDGF molecule by the aptamer pair enables the hybridization between the complementary sequences of both aptamer probes, which keeps two tail sequences of both aptamer probes in close proximity and promotes cooperative annealing of the aptamer‐protein‐aptamer sandwiched complex on capture probes immobilized on the electrode. Thus, ferrocene tag at the terminus of one aptamer probe is drawn in close contact with the electrode with strong redox signal readily obtained in voltammetric reading. The aptasensor is shown to have high sensitivity with a detection limit as low as 0.1 pg mL−1 and excellent specificity with resistance to interference from coexisting proteins.
Electrochemical Aptasensors
Authors: Sassolas Audrey , Blum Loïc J. , Leca‐Bouvier Béatrice D. 
Published: April 2009

AbstractThis review presents electrochemical aptasensors reported in the literature. Their development has been growing as evidenced by the increasing number of scientific publications on this subject since 2004. Aptasensors are presented according to their transduction mode, including the most described amperometric and impedimetric devices as well as FETs and the first very recently reported potentiometric aptasensor. ‘Signal‐on’ (positive readout signal) and less sensitive ‘signal‐off’ (negative readout signal) aptasensors are reviewed based on target binding‐induced conformational change of aptamers or on target binding‐induced strand displacement or even on both processes. Aptamer‐labeled and aptamer label‐free devices are presented separately.
Characterization of Rhizobacteria Isolated from Wild Coffea arabica L.
Authors: Muleta D. , Assefa F. , Hjort K. , Roos S. , Granhall U. 
Published: April 2009

AbstractRhizobacteria from wild Arabica coffee populations (Coffea arabica L.) in southwestern Ethiopia were isolated and characterized. The main purpose was to identify coffee‐associated rhizobacteria and evaluate their potential in synthesizing the phytohormone indole acetic acid (IAA) and in degrading the ethylene precursor 1‐aminocyclopropane‐1‐carboxylate (ACC). A total of 878 bacterial isolates were screened, of which 395 (45%) isolates were preliminarily characterized using metabolic identification kits (API). Both Gram‐negative and Gram‐positive bacteria were isolated, with the former group predominating (63% of cases). Based on pre‐screening results of the biochemical tests, 51 of the isolates were subjected to PCR‐RFLP (Restriction Fragment Length Polymorphism) analysis that yielded ten groups, of which 24 isolates were identified by 16S rRNA gene sequencing. The major genera identified were Pseudomonas (six species) and Bacillus (four species). Single species of Erwinia, Ochrobactrum and Serratia were also identified. The Erwinia sp., Serratia marcescens and many Pseudomonas spp. produced IAA, and some isolates (all Pseudomonas spp.) were also able to degrade ACC. Several of the microbes found in association with wild Arabica coffee bushes have potential agronomic importance, like e.g. Bacillus thuringiensis, which deserve further testing. According to these in vitro studies, isolates of Erwinia, Serratia and Pseudomonas are of particular interest in inoculant development due to their plant growth promoting traits.
Biofuels – challenges & chances: How biofuel development can benefit from advanced process technology
Authors: Knocke Christof , Vogt Jennefer 
Published: April 2009

AbstractThe presented article highlights the process of biofuel production with a special focus on bioethanol. After a short introduction to the “problems” of biofuels – the “first generation” biofuels (in regards to their competition to feed and food production) and the “second generation” biofuels (in regards to the required more complex process technology) − the different steps in the process from natural resources towards the final product are presented and the underlying biotechnological challenges discussed: the pre‐treatment of the natural resources followed by the biotechnological processes of hydrolysis and fermentation. Topics such as enzyme screening for efficient or even multi‐step hydrolysis as well as microbial strain selection under process conditions and the optimization of the anaerobic fermentative conversion of the saccharides to bioethanol are discussed. Optimizing the production of bioethanol to be competitive with petrochemical fuels is the main challenge for the underlying process development.
Effects of nitrogen source, empty bed residence time and inlet concentration on biofilter removal of chlorobenzene
Authors: Wang Can , Xi Jin‐Ying , Hu Hong‐Ying 
Published: April 2009

AbstractA new biofilter with bamboo carriers was used to remove gaseous chlorobenzene. Operating parameters such as the nitrogen source, the empty bed residence time (EBRT) and the inlet concentration of chlorobenzene were varied. The ability of the biofilter to remove chlorobenzene was evaluated under each set of conditions. The experimental results indicated that better biofilter performance was achieved using ammonium instead of nitrate nitrogen as the nitrogen source. However, an addition of excess ammonium did not further increase the removal efficiency. The optimal ratio of carbon to nitrogen supply (C/N) was 7:1−14:1. Increasing EBRT increased the biofilter efficiency from 0‐20% (EBRT=24 s) to 30‐50% (EBRT=41 s) and to 50‐70% (EBRT=122 s). The relationship between removal efficiency and EBRT indicated that the removal of chlorobenzene is a pseudo first order kinetic process below the concentration of 400 mg/m3. A substrate inhibition model, the Haldane equation, successfully described the removal rate of the biofilter at various inlet concentrations. With increasing inlet concentration, the removal rate initially rose and then declined. The highest removal rate of 18 g/m3 ×h was achieved at an inlet concentration of 1440 mg/m3.
Purification and characterization of lignin peroxidase from Loweporus lividus MTCC‐1178
Authors: Yadav Meera , Yadav Pratibha , Yadav Kapil Deo Singh 
Published: April 2009

AbstractLignin peroxidase from the culture filtrate of Loweporus lividus MTCC‐1178 has been purified to homogeneity using Amicon concentration and DEAE cellulose chromatography. The molecular weight of the purified lignin peroxidase using SDS‐PAGE analysis has been found to be 40 kDa. The Km values for veratryl alcohol and H2O2 for the purified enzyme were 58 and 83 μM, respectively. The calculated kcat value of the purified enzyme using veratryl alcohol as the substrate was 2.5 s−1. The pH and temperature optima of lignin peroxidase have been found to be 2.6 and 24°C, respectively.
Removal of synthetic dyes by an eco‐friendly strategy
Authors: Rodríguez‐Couto Susana , Osma Johann Faccelo , Toca‐Herrera José Luis 
Published: April 2009

AbstractIn this paper an eco‐friendly strategy for the removal of synthetic dyes from aqueous solutions was proposed. Thus, in a first step the dyes were adsorbed onto sunflower seed shells (SS) by using a batch technique. Subsequently, in a second step, these dyed SS were used as support‐substrates to produce laccase by the white‐rot fungus Trametes pubescens under semi‐solid‐state conditions. The effect of inducer addition on laccase production was studied. The optimum conditions (addition of both 0.5 mM Cu+2 and 50 μM tannic acid on the 3rd day of cultivation) led to a maximum laccase activity of 30272 U/L. Further, the system was efficiently scaled‐up to laboratory bioreactors producing a maximum activity of 40172 U/L together with a total decolouration of the adsorbed dye. In addition, SDS‐PAGE showed that laccases were the only enzymes present in the extracellular fluid. Therefore, apart from dye removal this approach allowed the production of high titres of laccase, which was obtained almost pure (only needed to be ultra‐filtrated).