bluuebunny/crossref_metadata_2025_split huggingface dataset:
МЕТОД АНАЛІЗУ ВИМОГ ДО ПРОГРАМНОГО ЗАБЕЗПЕЧЕННЯ НА ПРЕДМЕТ ПОШУКУ ЗНАЧЕНЬ АТРИБУТІВ ЯКОСТІ
Authors: ВОЙЧУР Юрій , МЕДЗАТИЙ Дмитро 
Published: April 2024

Ринок програмного забезпечення (ПЗ) зростає дуже стрімко. ПЗ стає все більш складним, і на нього покладається все більша відповідальність. Зі зростанням надійності апаратного забезпечення та зростаючою складністю програмного забезпечення якість програмного забезпечення викликає дедалі більше занепокоєння як у розробників, так і у користувачів, щонайменше виходячи з прагнення досягти поставлені бізнес-цілі.
Наразі існує суперечність між зростаючою складністю програмного забезпечення та відповідальністю, яка на нього покладається, розширенням вимог до якості програмного забезпечення, з одного боку, і недосконалістю моделей, методів та засобів прогнозування якості ПЗ на ранніх етапах життєвого циклу. Відтак, прогнозування рівня якості програмного забезпечення на ранніх етапах життєвого циклу на основі атрибутів якості є актуальною задачею.
Розроблена структура специфікації вимог до ПЗ, придатної для автоматичного опрацювання системою для прогнозування рівня якості програмного забезпечення на основі вимог, накладає певні обмеження на формулювання вимог, що містять атрибути якості, та призначена для подальшого препроцесінгу специфікаційї вимог до ПЗ.
Метод аналізу вимог до програмного забезпечення на предмет пошуку значень атрибутів якості забезпечує вибір значень атрибутів якості ПЗ з природомовної специфікації вимог до ПЗ, які далі можуть бути використані для визначення значень характеристик якості ПЗ та для комплексного оцінювання якості ПЗ. Розроблений метод є важливим для повної автоматизації опрацювання вимог та повного усунення суб’єктивного впливу і участі людини у процесах опрацювання інформації та здобуття знань. Метод аналізу вимог до ПЗ на предмет пошуку значень атрибутів якості є теоретичним підгрунтям для розроблення модулю автоматичного аналізу вимог до ПЗ пропонованої авторами системи для прогнозування рівня якості програмного забезпечення на основі вимог.
ІННОВАЦІЙНІ ПІДХОДИ ДО ФОРМУВАННЯ МІЖНАРОДНОЇ КОМУНІКАЦІЙНОЇ ПОЛІТИКИ ПІДПРИЄМСТВА В КРИЗОВИХ УМОВАХ
Authors: ХАЧАТРЯН Валентина , СТРАТІЙЧУК Вікторія 
Published: April 2024

У статті здійснено аналіз сутності міжнародної комунікаційної політики підприємства. Виокремлено основні підходи науковців щодо трактування даного поняття. Визначено цілі комунікаційної політики підприємства з міжнародною діяльністю. Побудовано типову модель комунікаційного процеус підприємства з міжнародною діяльністю. Виділено чинники, що впливають на ефективність комунікаційної політики підприємства з міжнародною діяльністю. Узагальнено критерії оцінювання якісних показників ефективності комунікаційної політики міжнародної компанії, а також основні методи оцінювання ефективності комунікативної політики підприємства. Запропоновано інноваційні принципи реалізації комунікаційної політики на міжнародному ринку.
Comparative analysis of various laboratory biomarkers based on the severity of COVID-19 in a tertiary care hospital in South India
Authors: Elango Karthick , Selvarajan Sathya , Krishnamurthy Sowmya 
Published: April 2024

COVID-19 (Corona Virus Disease 2019) was a life-changing pandemic with impact on social, environmental, health, and economic issues. Various inflammatory and hematological biomarkers studied individually or in combination in the literature have shown significant results with regard to COVID-19 pathology, severity, and prognosis. Yet the question of interest is how covid-19 inflammatory cascade impacts the interlink between the biomarkers during different stages. This study aims to retrospectively analyse ferritin, albumin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, direct bilirubin, blood urea nitrogen (BUN), creatinine, D-dimer, Lactate Dehydrogenase (LDH), C Reactive Protein (CRP) and Interleukin-6 (IL-6) levels between two groups based on COVID-19 severity. A retrospective cross-sectional study was conducted with laboratory data of COVID-19 patients admitted at Sri Ramachandra Medical College Hospital, India. The sample size was 104 [Group1: severe disease, n=52; Group-2: mild disease, n=52]. After normality testing, data were compared between the two groups followed by correlation analysis between the variables. A p<0.05 was considered statistically significant. On comparison, Group 2 (severe COVID-19 disease) showed significant difference in the levels of all the biomarkers (p<0.005) except Creatinine (p<0.128) when compared with Group 1 (mild COVID-19 disease). Significant correlation was obtained between all biomarkers (p<0.005) except creatinine. The correlation analysis primarily explains the inflammatory cascade involved in disease. Ferritin appears to have a standalone effect on disease severity, progression, organ dysfunction. This understanding can be used to provide better and more timely care.
تاثير التدريس بالمجمعات التعليمية باستخدام التمارين المركبة بتعلم بعض انواع التهديف بكرة السلة
Authors: Prof. Dr. Imad Touma Radi  
Published: April 2024

الملخص
يهدف البحث
- التعرف الى تاثير استخدام التدريس بالمجمعات التعليمية وفق التمارين المركبة لتحسين انواع التهديف
- التعرف الى تاثير استخدام التدريس بالمجمعات التعليمية وفق التمارين المركبة لتحسين بعض انواه التهديف بكرة السلة (التهديف من خط الرمية الحرة .التهديف بالقفز. التهديف السلمي).
وفروض البحث والمجالات واستخدم الباحثون المنهج التجريبي وكذلك عينة البحث وهم طلاب المرحلة الاولى بكلية التربية البدية وعلوم الرياضة الجامعة المستنصرية والبالغ عددهم (60) قسموا الى مجموعتين متساويتين تجريبية والضابطة وشمل على عدد من الوحدات التعليمية والبالغ عددها (8) وحدات طبق على عينة البحث حيث تم استخدام التدريس بالمجمعات التعليمية باستخدام التمارين المركبة على المجموعة التجريبية .
توصل البحث الى اهم النتائج منها
- اظهرت النتائج تقدم المجموعة التجريبية التي استخدمت التدريس بالمجمعات التعليمية والتمرينات المركبة في تحسن انواع التهديف بكرة السلة ( المناولة الطويلة من فوق الكتف و الطبطبة والتهديف من خط الرمية الحرة )على المجموعة الضابطة .
- اظهرت النتائج تحسن المجموعة الضابطة التي استخدمت التدريس المتبع من قبل المدرس في تعلم بعض المهارات والتوافق الحركي بكرة السلة.
No causal association between the volume of strenuous exercise and coronary atherosclerosis: a two-sample Mendelian randomization study
Authors: Xiao Zijie , Huang Guolin , Li Guanhong , Wang Huihui , Zheng Xiaoyu , Li Yongchun , Gong Fengying , Lv Ying , Li Jingjun 
Published: April 2024

ObjectiveSeveral observational studies have shown that high-volume and high-intensity exercise training increases the prevalence and severity of coronary atherosclerosis, but the causal effect still remains uncertain. This study aims to explore the causal relationship between the volume of strenuous exercise (SE) and coronary atherosclerosis (CA) using the Mendelian randomization (MR) method.MethodThe exposure factors were two basic parameters of the volume of strenuous exercise (duration and frequency of strenuous exercise), the outcome factor was coronary atherosclerosis, and the relevant genetic loci were extracted from the summary data of the genome-wide association study (GWAS) as the instrumental variables, and MR analyses were performed using the inverse variance weighting (IVW) method, the weighted median method, and the MR-egger method. Sensitivity analyses were performed using heterogeneity analysis, pleiotropy analysis, and the “leave-one-out” method. The original results were tested using other coronary atherosclerosis data sets.ResultIVW results showed no causal association between duration of strenuous exercise (DOSE) [OR = 0.9937, 95% CI (0.9847, 1.0028), P = 0.1757] and frequency of strenuous exercise (FOSE) in the last 4 weeks [OR = 0.9930, 95% CI (0.9808, 1.0054), P = 0.2660] and coronary atherosclerosis. All of the above results were validated with other coronary atherosclerosis data sets.ConclusionThe present study supports that the causal association of duration and frequency of SE with CA was not found, and provides valuable insights into the choice of scientific and correct volume of SE to cardiac rehabilitation (CR).
Beyond technology acceptance—a focused ethnography on the implementation, acceptance and use of new nursing technology in a German hospital
Authors: Klawunn Ronny , Albrecht Urs-Vito , Katzmarzyk Deliah , Dierks Marie-Luise 
Published: April 2024

IntroductionHospitalised patients could benefit from the emergence of novel technologies for nursing care. There are numerous technical products available, but these rarely find their way into practice. Further knowledge is required about the circumstances under which technology in nursing is accepted and used. In the research project “Centre for Implementing Nursing Care Innovations”, technical innovations are implemented on a trauma surgery inpatient ward in Germany. After implementation, it was investigated: Which implemented technologies are accepted/rejected, and which factors influence the acceptance/rejection of technology for nurses?Material and methodsA focused ethnography was used, containing two approaches: First, participant observation was conducted to examine nurses’ and patients’ interaction with technologies. Observations were fixed in a field research diary and analysed using evaluative qualitative content analysis. Second, a questionnaire was used by nurses to provide information about the use frequency and technology suitability. The results of the study were consolidated and analysed using the UTAUT model.ResultsSeven studied technologies can be summarised in four result categories: (1) A Mobilising mattress, a Special projector and a Sound pillow are accepted and used by nurses and patients, because they offer a way to provide high quality care with little additional effort. (2) A Fall prevention system is consistently used in patient care as a work obligation, but since nurses consider the system error-prone, acceptance is low. (3) An Interactive therapy ball is accepted but nurses cannot use it due to the high workload. (4) An App for nurse-patient communication and a work-equipment tracking system are not used or accepted because nurses do not see a practical benefit in the systems.DiscussionAcceptance or rejection of a product does not necessarily equate to use or non-use of the technology. Before implementation, technology acceptance among users occurs as prejudice—when users are given time to experiment with technology, intention-to-use can stabilize into sustained use. Accepted and used technologies can serve to mask problems (such as staff shortages) and encourage problematic developments, such as the reduction of contact time at the bedside. Therefore, technology acceptance should be qualified in asking to what accepted technology contributes.
Causal associations of cognition, intelligence, education, health and lifestyle factors with cervical spondylosis: a mendelian randomization study
Authors: Ren Zhenxiao , Cheng Xing , Xu Jinghui , Niu Tianzuo , Long Houqing 
Published: April 2024

Background: Education, cognition, and intelligence are phenotypically and genetically related. Education has been shown to have a protective effect on the risk of developing cervical spondylosis. However, it is unclear whether cognition and intelligence have independent causal effects on cervical spondylosis, and whether health and lifestyle factors influence this association.Methods: We first assessed the independent effects of education, cognition, and intelligence on cervical spondylosis by two-sample Mendelian randomization and multivariable Mendelian randomization analysis, and evaluated 26 potential association mediators using two-step Mendelian randomization, and calculated the median proportion.Results: The results showed that only education had an independent causal effect on cervical spondylosis, and had a protective effect on the risk of cervical spondylosis (β: 0.3395; se: 0.166; p &lt; 0.05; OR:0.71; [95%CI: 0.481–0.943]. Of the 26 potential associated mediators, a factor was identified: SHBG (mediated proportion: 2.5%). Univariable Mendelian randomization results showed that the risk factors for cervical spondylosis were time spent watching TV (OR:1.96; [95%CI: 1.39–2.76]), smoking (OR:2.56; [95%CI: 1.061–1.486]), body mass index (OR:1.26; [95%CI: 1.124–1.418]), percentage of body fat (OR:1.32; [95%CI: 1.097–1.593]), major depression (OR:1.27; [95%CI: 1.017–1.587]) and sitting height (OR:1.15; [95%CI: 1.025–1.291]). Protective factors include computer using (OR:0.65; [95%CI: 0.418–0.995]), sex hormone binding globulin (OR:0.87; [95%CI: 0.7955–0.951]) and high-density lipoprotein (OR:0.90; [95%CI: 0.826–0.990]).Conclusion: Our findings demonstrate the causal and independent effects of education on cervical spondylosis and suggest that lifestyle media may be a priority target for the prevention of cervical spondylosis due to low educational attainment.
KIF1C and new Huntingtin-interacting protein 1 binding proteins regulate rheumatoid arthritis fibroblast-like synoviocytes’ phenotypes
Authors: Laragione Teresina , Harris Carolyn , Gulko Percio S. 
Published: April 2024

BackgroundHuntingtin-interacting protein-1 (HIP1) is a new arthritis severity gene implicated in the regulation of the invasive properties of rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS). These invasive properties of FLS strongly correlate with radiographic and histology damage in patients with RA and rodent models of arthritis. While HIP1 has several intracellular functions, little is known about its binding proteins, and identifying them has the potential to expand our understanding of its role in cell invasion and other disease-contributing phenotypes, and potentially identify new targets for therapy.MethodsFLS cell lines from arthritic DA (highly invasive) and from arthritis-protected congenic rats R6 (minimally invasive), which differ in an amino-acid changing HIP1 SNP, were cultured and lysed, and proteins were immunoprecipitated with an anti-HIP1 antibody. Immunoprecipitates were analyzed by mass spectrometry. Differentially detected (bound) proteins were selected for functional experiments using siRNA knockdown in human RA FLS to examine their effect in cell invasiveness, adhesion, cell migration and proliferation, and immunofluorescence microscopy.ResultsProteins detected included a few known HIP1-binding proteins and several new ones. Forty-five proteins differed in levels detected in the DA versus R6 congenic mass spectrometry analyses. Thirty-two of these proteins were knocked down and studied in vitro, with 10 inducing significant changes in RA FLS phenotypes. Specifically, knockdown of five HIP1-binding protein genes (CHMP4BL1, COPE, KIF1C, YWHAG, and YWHAH) significantly decreased FLS invasiveness. Knockdown of KIF1C also reduced RA FLS migration. The binding of four selected proteins to human HIP1 was confirmed. KIF1C colocalized with lamellipodia, and its knockdown prevented RA FLS from developing an elongated morphology with thick linearized actin fibers or forming polarized lamellipodia, all required for cell mobility and invasion. Unlike HIP1, KIF1C knockdown did not affect Rac1 signaling.ConclusionWe have identified new HIP1-binding proteins and demonstrate that 10 of them regulate key FLS phenotypes. These HIP1-binding proteins have the potential to become new therapeutic targets and help better understand the RA FLS pathogenic behavior. KIF1C knockdown recapitulated the morphologic changes previously seen in the absence of HIP1, but did not affect the same cell signaling pathway, suggesting involvement in the regulation of different processes.
EMMPRIN promotes spheroid organization and metastatic formation: comparison between monolayers and spheroids of CT26 colon carcinoma cells
Authors: Feigelman Gabriele , Simanovich Elina , Brockmeyer Phillipp , Rahat Michal A. 
Published: April 2024

BackgroundIn vitro studies often use two-dimensional (2D) monolayers, but 3D cell organization, such as in spheroids, better mimics the complexity of solid tumors. To metastasize, cancer cells undergo the process of epithelial-to-mesenchymal transition (EMT) to become more invasive and pro-angiogenic, with expression of both epithelial and mesenchymal markers.AimsWe asked whether EMMPRIN/CD147 contributes to the formation of the 3D spheroid structure, and whether spheroids, which are often used to study proliferation and drug resistance, could better model the EMT process and the metastatic properties of cells, and improve our understanding of the role of EMMPRIN in them.MethodsWe used the parental mouse CT26 colon carcinoma (CT26-WT) cells, and infected them with a lentivirus vector to knock down EMMPRIN expression (CT26-KD cells), or with an empty lentivirus vector (CT26-NC) that served as a negative control. In some cases, we repeated the experiments with the 4T1 or LLC cell lines. We compared the magnitude of change between CT26-KD and CT26-WT/NC cells in different metastatic properties in cells seeded as monolayers or as spheroids formed by the scaffold-free liquid overlay method.ResultsWe show that reduced EMMPRIN expression changed the morphology of cells and their spatial organization in both 2D and 3D models. The 3D models more clearly demonstrated how reduced EMMPRIN expression inhibited proliferation and the angiogenic potential, while it enhanced drug resistance, invasiveness, and EMT status, and moreover it enhanced cell dormancy and prevented CT26-KD cells from forming metastatic-like lesions when seeded on basement membrane extract (BME). Most interestingly, this approach enabled us to identify that EMMPRIN and miR-146a-5p form a negative feedback loop, thus identifying a key mechanism for EMMPRIN activities. These results underline EMMPRIN role as a gatekeeper that prevents dormancy, and suggest that EMMPRIN links EMT characteristics to the process of spheroid formation.ConclusionsThus, 3D models can help identify mechanisms by which EMMPRIN facilitates tumor and metastasis progression, which might render EMMPRIN as a promising target for anti-metastatic tumor therapy.
Unveiling the hidden role of extracellular vesicles in brain metastases: a comprehensive review
Authors: Li Ji , Lu Shuangqing , Chen Feihu , Zhu Hui 
Published: April 2024

BackgroundExtracellular vesicles (EVs) are small, transparent vesicles that can be found in various biological fluids and are derived from the amplification of cell membranes. Recent studies have increasingly demonstrated that EVs play a crucial regulatory role in tumorigenesis and development, including the progression of metastatic tumors in distant organs. Brain metastases (BMs) are highly prevalent in patients with lung cancer, breast cancer, and melanoma, and patients often experience serious complications and are often associated with a poor prognosis. The immune microenvironment of brain metastases was different from that of the primary tumor. Nevertheless, the existing review on the role and therapeutic potential of EVs in immune microenvironment of BMs is relatively limited.Main bodyThis review provides a comprehensive analysis of the published research literature, summarizing the vital role of EVs in BMs. Studies have demonstrated that EVs participate in the regulation of the BMs immune microenvironment, exemplified by their ability to modify the permeability of the blood-brain barrier, change immune cell infiltration, and activate associated cells for promoting tumor cell survival and proliferation. Furthermore, EVs have the potential to serve as biomarkers for disease surveillance and prediction of BMs.ConclusionOverall, EVs play a key role in the regulation of the immune microenvironment of brain metastasis and are expected to make advances in immunotherapy and disease diagnosis. Future studies will help reveal the specific mechanisms of EVs in brain metastases and use them as new therapeutic strategies.
The incidence of surgical site infection and its predictors among women delivered via cesarean sections in Ethiopia: a systematic review and meta-analysis
Authors: Wondmeneh Temesgen Gebeyehu , Mohammed Jemal Abdu 
Published: April 2024

BackgroundAlthough surgical wound infection remains a serious issue worldwide, the disease burden is greater in developing countries, including Ethiopia. Even though there were primary studies conducted at district levels in Ethiopia, there is little evidence about the pooled incidence of surgical site infections at the national level. Thus, this systematic review and meta-analysis determined the pooled incidence of surgical site infection and its associated factors among cesarean-delivered women in Ethiopia.MethodsWe searched PubMed, CINAHL, African Journals Online, Google Scholar, and higher educational institutional repositories. A random-effects model was used to estimate the pooled effect size with 95% confidence intervals (CIs). Funnel plot and egger tests were computed to determine the existence of publication bias. A subgroup analysis was carried out.ResultsTwenty-three studies were included in the final analysis. The pooled incidence of surgical site infection among women delivered via cesarean section was 12.32% (95% CI: 8.96–16.11%). Rural residence (AOR = 2.51, 95% CI: 1.15–3.87), membrane rupture (AOR = 2.04, 95% CI: 1.24–2.85), chorioammionitis (AOR = 4.13, 95% CI: 1.45–6.8), general anesthesia (AOR = 1.99, 95% CI: 1.22–2.75), post-operative Hgb level less than 11 mg/dL (AOR = 3.25, 95% CI: 1.54–4.96) and membrane rupture greater or equal to 12 h (AOR = 3.93, 95% CI: 1.93–5.92) were independent risk factors for surgical site infections.ConclusionMore than one in 10 women delivered via cesarean section developed surgical site infections in Ethiopia. Women living in rural areas and those with a membrane rupture, chorioammionitis, or anemia should be given special attention. General anesthesia should not be a mandatory procedure.