bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of sexual function after radical prostatectomy
Authors: Briganti Alberto , Capitanio Umberto , Chun Felix K.‐H. , Karakiewicz Pierre I. , Salonia Andrea , Bianchi Marco , Cestari Andrea , Guazzoni Giorgio , Rigatti Patrizio , Montorsi Francesco 
Published: March 2010

AbstractRadical prostatectomy (RP) is a commonly used procedure in the treatment of clinically localized prostate cancer. For this report, the authors critically analyzed the factors associated with recovery of erectile function after surgery. A systematic review of the literature using the Medline and CancerLit databases was conducted. Keywords for the literature search included prostate cancer, radical prostatectomy, erectile dysfunction, impotence, treatment, and prophylaxis. Accurate patient selection (based on patient age, preoperative erectile function, and comorbidity profile) and adequate surgical technique (ie, the preservation of neurovascular bundles) were the major determinants of postoperative erectile function. Moreover, better results were achieved when an appropriate pharmacologic treatment using either oral or local approaches was given. Therefore, the authors concluded that, if patients are stratified correctly according to preoperative, intraoperative, and postoperative factors, then a satisfactory functional recovery may be expected after surgery. For these reasons, an ideal multivariate model predicting the restoration of erectile function after surgery should include patient, surgeon, and postsurgical treatment variables. The authors also concluded that the stratification of patients with regard to their risk of developing erectile dysfunction after surgery was feasible based on several parameters, which should be taken into account for correct patient treatment and counseling. To address this objective, accurate tools for predicting the likelihood of complete functional recovery after surgery are needed. Cancer 2009;115(13 suppl):3150–9. © 2009 American Cancer Society.
Predictive models in palliative care
Authors: Ripamonti Carla Ida , Farina Gabriella , Garassino Marina Chiara 
Published: March 2010

AbstractIt is important to identify prognostic and predictive factors concerning both life expectancy and quality of life in palliative care patients to facilitate ethical, clinical, and organizational decisions, but also to use resources in the best possible way. The authors reviewed the literature to identify the major factors that can predict survival of patients with solid tumors. They found only a few prospective assessments of prognostic factors. Clinical prognostic/predictors of survival based on physician's and/or nurse's judgment, performance status, dyspnea at rest, anorexia, dysphagia, or delirium are all considered to be of primary importance. Despite several contrasting findings, it is generally agreed that the type and site of the primary tumor and metastasis, psychosocial factors, and quality of life should be considered secondary to the organic effects in the final stages of life. Leukocytosis, lymphocytopenia, and elevated C‐reactive protein are all reported to have prognostic significance, and low serum albumin and high lactate dehydrogenase levels must also be taken into consideration. Cancer 2009;115(13 suppl):3128–34. © 2009 American Cancer Society.
Development of a prostate cancer metagram
Authors: Nguyen Carvell T. , Kattan Michael W. 
Published: March 2010

AbstractMany treatment options are available to the human with clinically localized prostate cancer, including surgery, radiation, and even active surveillance. To the authors' knowledge, there is no consensus on the optimal management of this patient population, with most clinicians tending to recommend the treatment with which they are most familiar. Effective patient counseling allowing informed decision making can be best achieved with a formalized system that offers accurate predictions of outcomes for all available treatment approaches. The authors organized the currently available prostate cancer prediction tools toward the formation of a metagram that can be used to tailor management to the individual patient. A comprehensive review of the literature was performed to identify published prediction tools intended for use in prostate cancer. Tools were categorized by a combination of treatment modality and the outcome being predicted, and incorporated into a metagram constructed of 16 different treatment options and 10 outcomes related to cancer control, survival, and morbidity. A search of the literature revealed 44 prostate cancer prediction tools that assessed at least 1 of the 160 treatment/outcome combinations that comprise the metagram. Only 31 cells of the metagram were populated with currently available tools. Prediction tools offer the most accurate estimates of outcomes in prostate cancer, but their current role in patient counseling is complicated by the large number of existing tools, as well as a lack of comparative data. To address this, the authors incorporated the most relevant prediction tools currently available into a prostate cancer metagram that may offer evidence‐based and individualized predictions for multiple endpoints after all available treatment options in clinically localized prostate cancer. The metagram also reveals areas of deficiency in the current catalog of prediction tools. Many more prediction tools are needed. Cancer 2009;115(13 suppl):3039–45. © 2009 American Cancer Society.
Area‐minimizing projective planes in 3‐manifolds
Authors: Bray H. , Brendle S. , Eichmair M. , Neves A. 
Published: March 2010

AbstractLet (M,g) be a compact Riemannian manifold of dimension 3, and let ℱ denote the collection of all embedded surfaces homeomorphic to
\input amssym ${\Bbb R}{ \Bbb P}^2$. We study the infimum of the areas of all surfaces in ℱ. This quantity is related to the systole of (M,g). It makes sense whenever ℱ is nonempty.In this paper, we give an upper bound for this quantity in terms of the minimum of the scalar curvature of (M,g). Moreover, we show that equality holds if and only if (M,g) is isometric to
\input amssym ${\Bbb R}{ \Bbb P}^3$
up to scaling.The proof uses the formula for the second variation of area and Hamilton's Ricci flow. © 2010 Wiley Periodicals, Inc.
Advances in Photoelectrocatalysis with Nanotopographical Photoelectrodes
Authors: Muñoz A. G. , Lewerenz H. J. 
Published: March 2010

AbstractThe design of photoelectrodes for high efficiency solar fuel energy conversion devices is based on the search for adequate surface conditioning to achieve efficient light harvesting, stability, minimized surface recombination losses and high electron‐transfer rates at the electrolyte interface. An overview on established and novel approaches is given. A recent viable solution is provided by electroplating of nanoscale catalytic metals on passivated semiconductor surfaces, thereby forming reactive centers and avoiding contact between the semiconductor surface and the electrolyte. At these nano‐dimensioned Schottky‐type junctions, light‐induced excess minority carriers are scavenged and transferred to the electrolyte. Various possible device configurations are outlined and envisaged systems for hydrogen or oxygen evolution and carbon dioxide reduction are presented. The role of ultrathin passivating films is emphasized and methods to fabricate open as well as compact conformal films are described.
p53 flow cytometry evaluation in leukemias: Correlation to factors affecting clinical outcome
Authors: Cavalcanti Geraldo Barroso , Scheiner Marcos Antonio Mauricio , Simões Magluta Eliane Pereira , Vasconcelos Flavia da Cunha , Klumb Claudete Esteves , Maia Raquel Ciuvalschi 
Published: March 2010

Abstractp53 is a cell cycle checkpoint control protein that assesses DNA damage and acts as a transcription factor regulating genes, which control cell growth, DNA repair, and apoptosis. p53 mutations have been found in a wide variety of different cancers including flow cytometric assessment of p53 protein expression using anti‐p53 monoclonal antibodies. We studied p53 protein expression by flow cytometry (FC) assay in 223 blood and/or bone marrow samples from 72 patients with chronic myeloid leukemia (CML): 54 in chronic phase (CML‐CP), 7 in accelerated phase (CML‐AP), and 11 in blastic phase (CML‐BP); 64 patients with chronic lymphoid leukemia (CLL): (34 at diagnosis, 21 in previously treated, and 9 with Richter's syndrome); 44 patients with acute lymphoid leukemia (ALL): 36 at diagnosis and 8 in relapse; and 43 acute myeloid leukemia (AML): 27 de novo, 7 in relapse, and 9 secondary. p53 protein expression was observed in 64 of 223 patient's samples: 14/64 (21.9%) CLL, 13/44 (29.5%) ALL, 19/43 (44.2%) AML, and 17/72 (23.6%) CML. Highest levels were detected in the advanced phases of CLL, ALL, and CML. In addition, in patients with AML, high levels of p53 expression were detected in secondary and relapse disease and also in de novo AML cases. Our results demonstrated that p53 expression levels are strongly associated with advanced disease. On the basis of these results, we concluded that FC can be a reliable approach to study p53 protein expression in leukemic patients. © 2010 Clinical Cytometry Society
Multiparameter immunophenotyping by flow cytometry in multiple myeloma: The diagnostic utility of defining ranges of normal antigenic expression in comparison to histology
Authors: Cannizzo Elisa , Bellio Emanuele , Sohani Aliyah R. , Hasserjian Robert P. , Ferry Judith A. , Dorn Michelle E. , Sadowski Craig , Bucci Janessa J. , Carulli Giovanni , Preffer Frederic 
Published: March 2010

AbstractBackground:Numerous studies have reported on the immunophenotype of plasma cells (PCs) in monoclonal gammopathy of undetermined significance (MGUS) and in plasma cell myeloma (PCM), but very few have examined the immunophenotype of normal PCs. In this study, an objective definition of normal range of expression for each antigen was found on normal control PCs. Using these new ranges of normal expression (new method) is different from using a static 20% of PCs cut‐off for all antigens as described in the literature (traditional method). These newly calculated normal ranges for each antigen were applied to our data, and compared to histologic and immunohistochemical findings.Methods:Bone marrow samples from 46 patients with PC neoplasms and 15 normal controls were studied. A minimum of 100 PC were analyzed for each patient and control sample. An 8‐color staining method was applied to study the immunophenotype of PCs, using a BD FACSCanto II.Results:By the new ranges of normality calculated in this study it was determined that different antigens have different level of expression on polyclonal PCs. CD19 correlated with histology by both the traditional and new methods, but had superior correlation by the new method.Conclusions:This report is the first 8‐color immunophenotypic study of PCM in which a “range of normal expression” for each antigen is defined. This is a critical step to help distinguish between a normal and neoplastic PC immunophenotype and discern which antigens are of diagnostic importance. © 2010 Clinical Cytometry Society
Synthesis and Characterization of 1‐, 2‐, and 3‐Dimensional Bimetallic UO22+/Zn2+ Phosphonoacetates (Eur. J. Inorg. Chem. 8/2010)
Authors: Knope Karah E. , Cahill Christopher L. 
Published: March 2010

AbstractThe cover picture shows three bimetallic UO22+/Zn2+ phosphonoacetates that have been prepared under hydrothermal conditions. The phosphonate linker was generated in situ by the hydrolysis of triethyl phosphonoacetate, as efforts to prepare uranyl/zinc bimetallic phases from the direct reaction of the metal salts with the acid form of the ligand were unsuccessful. These compounds exhibit diverse topologies and dimensionalities that can be attributed to polymerization of the UO22+ sites, oligomerization of Zn2+ octahedra, and degree of Zn2+–ligand coordination; structural features are related to temperature. Details are discussed in the article by K. E. Knope and C. L. Cahill on p. 1177 ff.
A Straightforward Hetero‐Diels–Alder Approach to (2‐ambo,4′R,8′R)‐α/β/γ/δ‐4‐Thiatocopherol
Authors: Menichetti Stefano , Amorati Riccardo , Bartolozzi Maria Grazia , Pedulli Gian Franco , Salvini Antonella , Viglianisi Caterina 
Published: March 2010

AbstractA simple and original inverse electron demand hetero‐Diels–Alder reaction has been successfully applied to the synthesis of (2‐ambo,4′R,8′R)‐α/β/γ/δ‐4‐thiatocopherol. Commercially available methyl hydroquinones and (2E,7R,11R)‐(+)‐phytol were exploited for the preparation of the ortho‐thioquinones, acting as electron‐poor dienes, and of the proper 1,3‐diene used as dienophile, respectively. The benzoxathiine cycloadducts, with the required tocopherol‐like skeleton, were obtained with complete control of regio and chemoselectivity. The antioxidant activity of 4‐thiatocopherols was measured and rationalized in comparison with that of the corresponding natural components of Vitamin E.
Chiral Thiophosphoramidate‐Catalyzed Asymmetric Michael Addition of Ketones to Nitro Olefins
Authors: Lu Aidang , Wu Ronghua , Wang Youming , Zhou Zhenghong , Wu Guiping , Fang Jianxin , Tang Chuchi 
Published: March 2010

AbstractA novel type of pyrrolidine‐based chiral (thio)phosphoramidates was synthesized. Among them, compound (S,aR)‐3d was proven to be an effective bifunctional organocatalyst for the asymmetric Michael addition of ketones to nitro olefins. The corresponding adducts were obtained in good to excellent chemical yields with high levels of diastereo‐ and enantioselectivities (up to >99:1 dr and 99 % ee).
Highly Enantioselective Conjugate Addition of Ketones to Alkylidene Malonates Catalyzed by a Pyrrolidinyl–Camphor‐Derived Organocatalyst
Authors: Magar Dhananjay R. , Chang Chihliang , Ting Ying‐Fang , Chen Kwunmin 
Published: March 2010

AbstractPyrrolidinyl–camphor derivatives have been proven to be efficient organocatalysts for enantioselective conjugate addition of ketones to alkylidene malonates, affording high chemical yields (up to 95 %) of the corresponding products with high to excellent levels of diastereoselectivity (up to >99:1 dr) and enantioselectivity (up to 96 % ee) under solvent‐free reaction conditions at ambient temperature.
Novel polydentate phosphonic acids: Protonation and stability constants of complexes with Fe(III) and Cu(II) in aqueous medium
Authors: Aliouane Nabila , Chafaa Salah , Douadi Tahar , Hélesbeux Jean‐Jacques , Khan Mustayeen A. , Duval Olivier , Bouet Gilles 
Published: March 2010

AbstractThe acido‐basic and the complexation properties of di‐, tri‐, and tetra‐phosphonic acids (H6L1, H8L2, and H10L3) toward Fe(III) and Cu(II) were determined by potentiometric titration in aqueous media at 25.0 ± 0.1°C with constant ionic strength (0.1 M, NaClO4). We have determined six, ten, and eight pKa values for the di, tri, and tetra‐phosphonic acids, respectively. In acidic conditions, e.g., 0 ≤ pH ≤ 5; iron and copper presented a high affinity toward these ligands to give complex species. With the ligand H10L3, [FeL3H7], and [CuL3H6]2− were easily obtained at pH 1.8 and 2.7, respectively. We have determined ten stability constants for the H10L3/Fe system and nine for the H10L3/Cu one; six and four in the cases of H8L2/Fe and H8L2/Cu systems, respectively. Finally, five stability constants were calculated for the H6L1/Fe system and four for the H6L1/Cu one. We have not observed any insoluble species in these complexes in acidic medium as well as in alkaline solutions. © 2010 Wiley Periodicals, Inc. Heteroatom Chem 21:51–62, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20575
Ultrasonically determined thyroid volume and thyroid functions in lithium‐naïve and lithium‐treated patients with bipolar disorder: a cross‐sectional and longitudinal study
Authors: Ozsoy Saliha , Mavili Ertugrul , Aydın Murat , Turan Tayfun , Esel Ertugrul 
Published: March 2010

AbstractObjectiveThis study investigated thyroid volume, hormone levels and antibodies in long‐term lithium‐treated and lithium‐naïve bipolar patients, some of whom underwent prospective follow‐up evaluations.MethodsFourteen lithium‐naïve patients, 13 long‐term lithium‐treated patients diagnosed with bipolar disorder and 12 healthy controls were included. Seven lithium‐naïve patients were followed‐up during their lithium receiving period (range 6–9 months). Thyroid volume and serum levels of thyroid hormones and antibodies were measured once in the long‐term lithium‐treated patients and controls, and twice in the lithium‐naïve patients, i.e. before and after lithium treatment.ResultsMean thyroid volumes in the lithium‐naïve patients were significantly higher than those in the controls. Long‐term lithium‐treated patients had significantly higher total thyroid volume than the lithium‐naïve patients and the controls. Total thyroid volume in the patients after the lithium treatment was significantly higher than that before. Serum free thyroxine (fT4) levels in the long‐term lithium‐treated patients were lower than those in the lithium‐naïve patients and the controls. In the lithium‐naïve patients, after lithium treatment, free triiodothyronine (fT3) levels were lower, and thyroid stimulating hormone (TSH) levels were higher compared to those before lithium treatment.ConclusionsThe results suggest that thyroid enlargement and some alterations in thyroid hormones in bipolar patients may present even before lithium treatment and increase further with lithium treatment. Copyright © 2010 John Wiley & Sons, Ltd.
The use of antidepressants in clinical practice: focus on agomelatine
Authors: McAllister‐Williams R. H. , Baldwin D. S. , Haddad P. M. , Bazire S. 
Published: March 2010

AbstractObjectiveAgomelatine (Valdoxan®) is licensed by the European Medicines Agency for the treatment of major depressive episodes in adults. The objective of this review was to consider how the drug should be used in clinical practice in particular starting, stopping and switching to and from the drug.MethodsThe existing clinical evidence was reviewed.ResultsData suggest that when switching to agomelatine from other antidepressants consideration should be given to tapering the previous antidepressant in order to minimize the risk of the original drug causing discontinuation/withdrawal symptoms. The risk of pharmacological interactions between most antidepressants and agomelatine is low and so tapering the previous antidepressant can usually be done after agomelatine has been started. An exception is fluvoxamine which should not be concurrently prescribed with agomelatine. As agomelatine appears to cause no significant discontinuation symptoms, it can probably be stopped abruptly when treatment is completed or when switching to another antidepressant.ConclusionsWhile this guidance may change as clinical evidence and experience grows, currently agomelatine appears to have a good tolerability profile and is relatively easy to use, though prescribers should note the requirement to conduct liver function tests (LFTs) in accordance with the Summary of Product Characteristics (SPC). Copyright © 2010 John Wiley & Sons, Ltd.
Risperidone associated weight, leptin, and anthropometric changes in children and adolescents with psychotic disorders in early treatment
Authors: Maayan Lawrence A. , Vakhrusheva Julia 
Published: March 2010

AbstractObjectiveTo document prospective weight and anthropometric changes in children and adolescents during the first 12 weeks of treatment with risperidone and evaluate metabolic outcomes including plasma leptin levels.MethodEight patients with psychotic disorders (ages 11–17) who had started risperidone (mean: 1.80 mg/day; sd = 1.04) in the prior 4 weeks participated in this observational study. Fasting morning blood samples were obtained at baseline and week 8 to assess glucose, leptin, cortisol, insulin, and triglycerides. Measures of body mass index (BMI), weight, waist and hip circumference, blood pressure, and heart rate were obtained weekly.ResultsParticipants increased in mean weight (4.16 kg; sd = 4.36; p = 0.03) and BMI (1.47 kg/m2; sd = 1.53; p = 0.03) with five out of eight gaining at least 7% of baseline body weight. They had a 4.03 cm (sd = 3.82; p = 0.02) increase in waist circumference and a 5.17 cm (sd = 3.68; p = 0.01) increase in hip circumference. Leptin trended higher, but did not reach statistical significance. There were no significant changes in glucose, insulin, cortisol, blood pressure, or heart rate.ConclusionSubjects experienced significant increases in weight, BMI, hip and waist circumference during the first 3 months of treatment. Better powered research with more advanced anthropometric assessment is warranted to further elucidate mechanisms of antipsychotic associated weight gain in youth. Copyright © 2010 John Wiley & Sons, Ltd.
An improved in silico selection of phenotype affecting polymorphisms in SLC6A4, HTR1A and HTR2A genes
Authors: Piva Francesco , Giulietti Matteo , Nardi Bernardo , Bellantuono Cesario , Principato Giovanni 
Published: March 2010

AbstractObjectiveAmong the experimentally assessed DNA variations in serotonin related genes, some influence physiological expression of personality and mental disorders, others alter the responses to pharmacological and/or psychotherapeutic treatments. Because of the huge number of polymorphisms lying in genes and of the great length of time necessary to perform association studies, a selection of the variations being studied is a necessary and crucial step.MethodsIn this work we used the most updated and assessed bioinformatic tools to predict the phenotype affecting polymorphisms of the human HTR1A, HTR2A and SLC6A4 serotonin related genes. Moreover, we carried out a literature search to collect information about the recent association studies to compare it versus our prediction data.ResultsGene polymorphism analysis indicated the variations that are worth considering in the association studies in the field of psychiatry, psychology and pharmacogenomics. The literature revision allowed to show both the few well and the most not enough investigated polymorphisms.ConclusionsOur data can be useful to select polymorphisms for new association studies, especially those not yet investigated that can be related to behaviour, mental disorders and individual treatment response. Copyright © 2010 John Wiley & Sons, Ltd.