bluuebunny/crossref_metadata_2025_split huggingface dataset:
Percutaneous Repair of Paravalvular Prosthetic Regurgitation
Authors: Sorajja Paul , Cabalka Allison K. , Hagler Donald J. , Rihal Charanjit S. 
Published: July 2011

Background—
Percutaneous repair has emerged as a potential therapy for patients with prosthetic paravalvular regurgitation. However, there is a relative paucity of data on the feasibility and outcome of this procedure.

Methods and Results—
All patients in whom percutaneous paravalvular regurgitation closure was attempted at our hospital were identified and included. Under echocardiographic and fluoroscopic guidance, patients underwent implantation of ≥1 an Amplatzer Septal Occluder, Duct Occluder, Muscular Ventricular Septal Defect Occluder, or Vascular Plug II. Percutaneous repair of 141 paravalvular defects was attempted in 115 patients (age, 67±12 years; men, 53%) with heart failure, hemolytic anemia, or both and who were at high risk of open surgery (mean estimated Society of Thoracic Surgeons mortality, 6.9%). Devices were implanted in 125 defects (89% of total defects), including in 19 patients with multiple defects. Because of the complexity of the procedures, wire exteriorization was required in 29 patients. Overall, successful percutaneous closure (defined as ≤1+ residual regurgitation) was achieved in 88 (77%) patients. Procedural time decreased with increasing case experience for percutaneous repair of both perimitral and periaortic defects. Overall, the 30-day complication rate was 8.7% (sudden and unexplained death, 1.7%; stroke, 2.6%; emergency surgery, 0.9%; bleeding, 5.2%). Two devices embolized during the procedure and were retrieved without sequelae. No procedural deaths occurred, but 2 (1.7%) patients died by 30 days.

Conclusions—
Percutaneous repair of paravalvular prosthetic regurgitation can be performed with a reasonable rate of procedural success and may be an initial therapeutic option, particularly in patients at significant risk for open surgery. Increased case experience is associated with shorter procedural time.
Impact of Coronary Plaque Morphology Assessed by Optical Coherence Tomography on Cardiac Troponin Elevation in Patients With Elective Stent Implantation
Authors: Lee Tetsumin , Yonetsu Taishi , Koura Kenji , Hishikari Keiichi , Murai Tadashi , Iwai Toshiyuki , Takagi Takamitsu , Iesaka Yoshito , Fujiwara Hideomi , Isobe Mitsuaki , Kakuta Tsunekazu 
Published: July 2011

Background—
Mild elevations of cardiac troponin frequently occur after percutaneous coronary intervention (PCI), and patients with elevated post-PCI biomarkers have a worse prognosis. We used optical coherence tomography (OCT) to study the relationship between pre-PCI plaque morphology and post-PCI cardiac troponin I elevations.

Methods and Results—

One hundred thirty-one patients with normal pre-PCI cardiac troponin I levels underwent OCT before nonemergency stent implantation. Clinical and OCT findings were compared between patients with (n=31, 23.7%) and without (n=100, 76.3%) post-PCI cardiac troponin I of >3×upper reference limit (post-PCI myocardial infarction [MI]). After PCI, long-term follow-up data were collected. Post-PCI MI was associated with angiographic lesion length, type B2/C lesions, presence of thin-cap fibroatheroma, and fibrous cap thickness. In multivariable analysis, presence of thin-cap fibroatheroma (odds ratio, 10.47; 95% confidence interval, 3.74 to 29.28;
P
<0.001) and type B2/C lesions (odds ratio, 3.74; 95% confidence interval, 1.41 to 9.92;
P
=0.008) were predictors of post-PCI MI. At a median follow-up of 12 months, cardiac event-free survival was significantly worse in patients with post-PCI MI (log-rank test χ
2
=8.9;
P
=0.003). Cox proportional hazards analysis showed that post-PCI MI (hazard ratio, 3.67; 95% confidence interval, 1.39 to 9.65;
P
=0.009) and ejection fraction (hazard ratio, 0.96; 95% confidence interval, 0.92 to 0.99;
P
=0.029) were independent predictors of adverse cardiovascular events during follow-up.

Conclusions—
Type B2/C lesions and the presence of OCT-defined thin-cap fibroatheroma can predict post-PCI MI in patients treated with elective stent implantation, who may require adjunctive therapy after otherwise successful PCI.
Moist Dynamics of Severe Monsoons over South Asia: Role of the Tropical SST*
Authors: Pillai Prasanth A. , Annamalai H. 
Published: July 2011

Abstract
Diagnostics from observations and multicentury integrations of a coupled model [Geophysical Fluid Dynamics Laboratory (GFDL) coupled model version 2.1 (CM2.1)] indicate that about 65% of the severe monsoons (rainfall &gt; 1.5 standard deviations of its long-term mean) over South Asia are associated with sea surface temperature (SST) anomalies over the equatorial Pacific during the developing phase of ENSO, and another 30% are associated with SST variations over the tropical Indo-Pacific warm pool. The present research aims to identify the moist processes that initiate the dryness (wetness) and provide a precursor for rainfall anomalies over South Asia in spring during El Niño (La Niña). The hypothesis in this paper, based on CM2.1 composites, is that at low levels El Niño–forced equatorial easterly wind anomalies over the Indian Ocean, resulting from Ekman pumping, promote anticyclonic vorticity over the northern Indian Ocean, whose poleward flank advects dry air from northern latitudes to South Asia. This is tested by performing ensemble simulations with the atmospheric component of CM2.1 (AM2.1) and applying moisture and moist static energy budgets.
During El Niño, AM2.1 solutions capture the anticyclonic vorticity formation over the northern Indian Ocean 20–25 days earlier than organized negative rainfall anomalies over South Asia, and the advection of climatological air of lower moisture content by these anomalous winds initiates the dryness over South Asia from April onward. This long lead time embodied in this precursor signal can be exploited for predicting severe monsoons. During ENSO neutral conditions, the amplitude of regional SST anomalies during spring is insufficient to produce such a precursor signal.
The dominance of the term warrants monitoring the three-dimensional moisture distribution for better understanding, modeling, and predicting of severe monsoons.
The Mechanical Energies of the Global Atmosphere in El Niño and La Niña Years
Authors: Li Liming , Jiang Xun , Chahine Moustafa T. , Wang Jingqian , Yung Yuk. L. 
Published: July 2011

Abstract
Two meteorological reanalysis datasets are analyzed to determine the mechanical energies of the global atmosphere in the El Niño and La Niña years. The general consistency of the mean energy components between the two datasets reveals ~1%–3% increase and ~2%–3% decrease in the mean energies in the El Niño years and La Niña years, respectively. These analyses further reveal that the tropospheric temperature responds to the sea surface temperature anomaly with a time lag of two months, which leads to the varying mean atmospheric energies in the El Niño and La Niña years.
On the Suitability of GCM Runoff Fields for River Discharge Modeling: A Case Study Using Model Output from HadGEM2 and ECHAM5
Authors: Weiland F. C. Sperna , van Beek L. P. H. , Kwadijk J. C. J. , Bierkens M. F. P. 
Published: July 2011

Abstract
The representation of hydrological processes in land surface schemes (LSSs) has recently been improved. In this study, the usability of GCM runoff for river discharge modeling is evaluated by validating the mean, timing, and amplitude of the modeled annual discharge cycles against observations. River discharge was calculated for six large rivers using runoff, precipitation, and actual evaporation from the GCMs ECHAM5 and Hadley Centre Global Environmental Model version 2 (HadGEM2). Four methods were applied: 1) accumulation of GCM runoff, 2) routing of GCM runoff, 3) routing of GCM runoff combined with temporal storage of subsurface runoff, and 4) offline hydrological modeling with the global distributed hydrological model PCRaster Global Water Balance (PCR-GLOBWB) using meteorological data from the GCMs as forcing. The quality of discharge generated by all four methods is highly influenced by the quality of the GCM data. In small catchments, the methods that include runoff routing perform equally well, although offline modeling with PRC-GLOBWB outperforms the other methods for ECHAM5 data. For larger catchments, routing introduces realistic travel times, decreased day-to-day variability, and it reduces extremes. Complexity of the LSS of both GCMs is comparable to the complexity of the hydrological model. However, in HadGEM2 the absence of subgrid variability for saturated hydraulic conductivity results in a large subsurface runoff flux and a low seasonal variability in the annual discharge cycle. The analysis of these two GCMs shows that when LSSs are tuned to reproduce realistic water partitioning at the grid scale and a routing scheme is also included, discharge variability and change derived from GCM runoff could be as useful as changes derived from runoff obtained from offline simulations using large-scale hydrological models.
Predictability of Evapotranspiration Patterns Using Remotely Sensed Vegetation Dynamics during the North American Monsoon
Authors: Tang Qiuhong , Vivoni Enrique R. , Muñoz-Arriola Francisco , Lettenmaier Dennis P. 
Published: July 2011

Abstract
The links between vegetation, evapotranspiration (ET), and soil moisture (SM) are prominent in western Mexico—a region characterized by an abrupt increase in rainfall and ecosystem greenup during the North American monsoon (NAM). Most regional-scale land surface models use climatological vegetation and are therefore unable to capture fully the spatiotemporal changes in these linkages. Interannually varying and climatological leaf area index (LAI) were prescribed, both inferred from the space-borne Moderate Resolution Imaging Spectroradiometer (MODIS), as the source of vegetation parameter inputs to the Variable Infiltration Capacity (VIC) model applied over the NAM region for 2001–08. Results at two eddy covariance tower sites for three summer periods were compared and evaluated. Results show that both vegetation greening onset and dormancy dates vary substantially from year to year with a range of more than half a month. The model using climatological LAI tends to predict lower (higher) ET than the model using observed LAI when vegetation greening occurs earlier (later) than the mean greening date. These discrepancies were especially large during approximately two weeks at the beginning of the monsoon. The effect of LAI on ET estimates was about 10% in the Sierra Madre Occidental and 30% in the continental interior. VIC-estimated ET based on interannually varying LAI had high interannual variability at the greening onset and dormancy periods corresponding to the vegetation dynamics. The greening onset date was highly related to ET early in the monsoon season, indicating the potential usefulness of LAI anomalies for predicting early season ET.
On-Site Calibration for High Precision Measurements of Water Vapor Isotope Ratios Using Off-Axis Cavity-Enhanced Absorption Spectroscopy
Authors: Rambo Joshua , Lai Chun-Ta , Farlin James , Schroeder Matt , Bible Ken 
Published: July 2011

Abstract
Stable isotope ratio measurements of atmospheric water vapor (δ18Ov and δ2Hv) are scarce relative to those in precipitation. This limitation is rapidly changing due to advances in absorption spectroscopy technology and the development of automatically calibrated field-deployable instrument systems. These systems allow high throughput, in situ monitoring of the temporal variability in δ18Ov and δ2Hv. This paper presents a robust calibration procedure for reliable, high-precision δ18Ov and δ2Hv measurements at less than hourly intervals in this study. The method described here was developed and tested using a coupled system consisting of a commercial water vapor isotopic source device and a commercial water vapor isotope analyzer [Los Gatos Research (LGR) model WVIA-24] based on the off-axis integrated cavity output spectroscopy (off-axis ICOS) technique. The isotope analyzer shows a time-dependent response that varies with water vapor mixing ratio, suggesting the need of regular (hourly) calibration achievable by a single reference water source evaluated at a range of mixing ratios. By using a three-point calibration procedure with a range of user-specified water vapor mixing ratios, the authors were able to produce hourly δ18Ov and δ2Hv measurements with an overall accuracy (±0.2‰ for δ18O, ±0.5‰ for δ2H) and precision (±0.3‰ for δ18O, ±3.0‰ for δ2H) in the laboratory. The calibration procedure reliably produced data that were consistent with those collected by the conventional cryogenic method in an old-growth forest.
Assessment of the Impact of Observations on Analyses Derived from Observing System Experiments
Authors: Lupu Cristina , Gauthier Pierre , Laroche Stéphane 
Published: July 2011

Abstract
Observing system experiments (OSEs) are commonly used to quantify the impact of different observation types on forecasts produced by a specific numerical weather prediction system. Recently, methods based on degree of freedom for signal (DFS) have been implemented to diagnose the impact of observations on the analyses. In this paper, the DFS is used as a diagnostic to estimate the amount of information brought by subsets of observations in the context of OSEs. This study is interested in the evaluation of the North American observing networks applied to OSEs performed at the Meteorological Service of Canada for the period of January and February 2007. The relative values of the main observing networks over North America derived from DFS calculations are compared with those from OSEs in which aircraft or radiosonde data have been removed. The results show that removing some observation types from the assimilation system influences the effective weight of the remaining assimilated observations, which may have an increased impact to compensate for the removal of other observations. The response of the remaining observations when a given set of observations is denied is illustrated comparing DFS calculations with the observations’ impact estimated from OSEs.
Impact of the Environmental Low-Level Wind Profile on Ensemble Forecasts of the 4 May 2007 Greensburg, Kansas, Tornadic Storm and Associated Mesocyclones
Authors: Dawson II Daniel T. , Wicker Louis J. , Mansell Edward R. , Tanamachi Robin L. 
Published: July 2011

The early tornadic phase of the Greensburg, Kansas, supercell on the evening of 4 May 2007 is simulated using a set of storm-scale (1-km horizontal grid spacing) 30-member ensemble Kalman filter (EnKF) data assimilation and forecast experiments. The Next Generation Weather Radar (NEXRAD) level-II radar data from the Dodge City, Kansas (KDDC), Weather Surveillance Radar-1988 Doppler (WSR-88D) are assimilated into the National Severe Storms Laboratory (NSSL) Collaborative Model for Multiscale Atmospheric Simulation (COMMAS). The initially horizontally homogeneous environments are initialized from one of three reconstructed soundings representative of the early tornadic phase of the storm, when a low-level jet (LLJ) was intensifying. To isolate the impact of the low-level wind profile, 0–3.5-km AGL wind profiles from Vance Air Force Base, Oklahoma (KVNX), WSR-88D velocity-azimuth display (VAD) analyses at 0130, 0200, and 0230 UTC are used. A sophisticated, double-moment bulk ice microphysics scheme is employed. For each of the three soundings, ensemble forecast experiments are initiated from EnKF analyses at various times prior to and shortly after the genesis of the Greensburg tornado (0200 UTC). Probabilistic forecasts of the mesocyclone-scale circulation(s) are generated and compared to the observed Greensburg tornado track. Probabilistic measures of significant rotation and observation-space diagnostic statistics are also calculated. It is shown that, in general, the track of the Greensburg tornado is well predicted, and forecasts improve as forecast lead time decreases. Significant variability is also seen across the experiments using different VAD wind profiles. Implications of these results regarding the choice of initial mesoscale environment, as well as for the “Warn-on-Forecast” paradigm for probabilistic numerical prediction of severe thunderstorms and tornadoes, are discussed.
Surface Cold Pools in the Outer Rainbands of Tropical Storm Hanna (2008) Near Landfall
Authors: Eastin Matthew D. , Gardner Tiffany L. , Link M. Christopher , Smith Kelly C. 
Published: July 2011

Surface mesonet observations were used to document the structure of prominent cold pools associated with two convective outer rainbands of Tropical Storm Hanna on 5 September 2008. The developing rainbands were located ~400 km north of the storm center as they crossed the Carolina coastline and passed over the mesonet. The combination of moderate CAPE, moderate low-level cross-band vertical shear, and dry midlevel air provided an environment supportive of surface cold pool formation and long-lived quasi-linear convection. Both rainbands exhibited multiple outward-tilting convective cells and discrete line segments centered within a narrow zone of nearly continuous stratiform precipitation. The mesonet observations provided a unique along- and cross-band perspective of discrete cold pools situated beneath and behind the convection portions of each rainband. Prominent cold pools extended 40–80 km behind the rainband’s leading edge and exhibited maximum potential temperature, mixing ratio, and equivalent potential temperature deficits of 2–4 K, 1–2 g kg−1, and 4–10 K, respectively. In the cross-band direction, convergence of storm-relative inflow along the cold pool leading edge was coincident with a modest high pressure anomaly, while inflow divergence prevailed through the cold pool and rainfall maxima. Several cold pools expanded along-band while being advected downband by the prevailing cyclonic flow. Cold pool wakes were observed more than 50 km behind the rainband leading edge and up to 20 km downband from intense convection. Variations in cold pool intensity were not well correlated with convective intensity, rainfall rate, or the degree of midlevel dryness. Implications of prominent cold pools on tropical cyclone convection, size, and intensity are discussed.
Quality of Voice Evaluation in Patients Treated by Supracricoid Laryngectomy and Modified Supracricoid Laryngectomy
Authors: Allegra Eugenia , Lombardo Nicola , La Boria Alessandro , Rotundo Giuseppe , Bianco Maria Rita , Barrera Tiziana , Cuccunato Manuela , Garozzo Aldo 
Published: July 2011

ObjectiveTo compare quality of voice in patients treated by supracricoid laryngectomy and patients treated by modified supracricoid laryngectomy using the sternohyoid muscle for neoglottis reconstruction.Study DesignCase series.SettingTeaching hospital.Subjects and MethodsThis study was performed between 2004 and 2008 on 28 consecutive patients affected by T1b‐T2 laryngeal carcinoma. Eleven patients were treated by supracricoid laryngectomy, and 17 patients were treated by modified supracricoid laryngectomy. For each patient, postoperative parameters such as decannulation time, nasogastric feeding tube, and length of hospitalization were noted. Vocal function, Voice Handicap Index scores, and perceptual voice analysis scores on intelligibility, noise, fluency, and voice scale were evaluated.ResultsThe postoperative course of the patients treated by modified supracricoid laryngectomy was similar to patients treated by supracricoid laryngectomy. No delay in the length of hospitalization was detected in patients undergoing surgery with the new technique. A significant difference was detected in the nasogastric tube removal time and decannulation time. The data from intelligibility, noise, fluency, and voice scale analyses revealed a better quality of voice in patients treated by modified supracricoid partial laryngectomy with a significant difference in intelligibility, fluency, and voicing. The Voice Handicap Index mean value of physical, functional, and emotional subscales confirmed patients’ perceptions of a minor voice handicap in patients treated by modified supracricoid laryngectomy, with a significant difference on the physical subscale.ConclusionModified supracricoid laryngectomy seems to be a good way to improve quality of voice and quality of life in patients with early laryngeal cancer.
Identification of Flt3+CD150− myeloid progenitors in adult mouse bone marrow that harbor T lymphoid developmental potential
Authors: Chi Anthony W. S. , Chavez Alejandro , Xu Lanwei , Weber Brittany N. , Shestova Olga , Schaffer Andras , Wertheim Gerald , Pear Warren S. , Izon David , Bhandoola Avinash 
Published: July 2011

Abstract
Common myeloid progenitors (CMPs) were first identified as progenitors that were restricted to myeloid and erythroid lineages. However, it was recently demonstrated that expression of both lymphoid- and myeloid-related genes could be detected in myeloid progenitors. Furthermore, these progenitors were able to give rise to T and B lymphocytes, in addition to myeloid cells. Yet, it was not known whether these progenitors were multipotent at the clonogenic level or there existed heterogeneity within these progenitors with different lineage potential. Here we report that previously defined CMPs possess T-lineage potential, and that this is exclusively found in the Flt3+CD150– subset of CMPs at the clonal level. In contrast, we did not detect B-lineage potential in CMP subsets. Therefore, these Flt3+CD150– myeloid progenitors were T/myeloid potent. Yet, Flt3+CD150– myeloid progenitors are not likely to efficiently traffic to the thymus and contribute to thymopoiesis under normal conditions because of the lack of CCR7 and CCR9 expression. Interestingly, both Flt3+CD150– and Flt3–CD150– myeloid progenitors are susceptible to Notch1-mediated T-cell acute lymphoblastic leukemia (T-ALL). Hence, gain-of-function Notch1 mutations occurring in developing myeloid progenitors, in addition to known T-lineage progenitors, could lead to T-ALL oncogenesis.
Stomatin-deficient cryohydrocytosis results from mutations in SLC2A1: a novel form of GLUT1 deficiency syndrome
Authors: Flatt Joanna F. , Guizouarn Hélène , Burton Nicholas M. , Borgese Franck , Tomlinson Richard J. , Forsyth Robert J. , Baldwin Stephen A. , Levinson Bari E. , Quittet Philippe , Aguilar-Martinez Patricia , Delaunay Jean , Stewart Gordon W. , Bruce Lesley J. 
Published: July 2011

AbstractThe hereditary stomatocytoses are a series of dominantly inherited hemolytic anemias in which the permeability of the erythrocyte membrane to monovalent cations is pathologically increased. The causative mutations for some forms of hereditary stomatocytosis have been found in the transporter protein genes, RHAG and SLC4A1. Glucose transporter 1 (glut1) deficiency syndromes (glut1DSs) result from mutations in SLC2A1, encoding glut1. Glut1 is the main glucose transporter in the mammalian blood-brain barrier, and glut1DSs are manifested by an array of neurologic symptoms. We have previously reported 2 cases of stomatin-deficient cryohydrocytosis (sdCHC), a rare form of stomatocytosis associated with a cold-induced cation leak, hemolytic anemia, and hepatosplenomegaly but also with cataracts, seizures, mental retardation, and movement disorder. We now show that sdCHC is associated with mutations in SLC2A1 that cause both loss of glucose transport and a cation leak, as shown by expression studies in Xenopus oocytes. On the basis of a 3-dimensional model of glut1, we propose potential mechanisms underlying the phenotypes of the 2 mutations found. We investigated the loss of stomatin during erythropoiesis and find this occurs during reticulocyte maturation and involves endocytosis. The molecular basis of the glut1DS, paroxysmal exercise-induced dyskinesia, and sdCHC phenotypes are compared and discussed.