bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coactivator P100 Protein Enhances STAT6‐Dependent Transcriptional Activation But Has No Effect on STAT1‐Mediated Gene Transcription
Authors: Wang Xinting , Liu Xin , Fang Jianfei , Lu Yanxin , He Jinyan , Yao Xuyang , Yao Zhi , Yang Jie 
Published: March 2010

AbstractThe family of STAT proteins consists of seven members that mediate highly specific functions in cytokine signaling. STAT6 is a critical regulator of transcription for interleukin‐4 (IL‐4)‐induced genes. Activation of gene expression involves recruitment of coactivator proteins that function as bridging factors connecting sequence‐specific transcription factors to the basal transcription machinery, and as chromatin‐modifying enzymes. In this report, we show that the coacitivator p100 protein can interact with STAT6 through its SN domain both in vivo and in vitro, resulting in enhancement of STAT6‐mediated gene transcriptional acitivation. Consistent with our previous reports, we identified intracellular localization of p100 and STAT‐6 by confocal microscopy examined in response to IL‐4. Moreover, in consideration of STAT molecules sharing significant homology in structure and function, we detected whether p100 can associate with STAT‐1. In conclusion, this study found no evidence that p100 functions as a transcriptional coactivator for STAT1‐dependent gene regulation. Anat Rec, 2010. © 2010 Wiley‐Liss, Inc.
Contextual cocitation: Augmenting cocitation analysis and its applications
Authors: Callahan Alison , Hockema Stephen , Eysenbach Gunther 
Published: March 2010

AbstractIn this work, a novel method of cocitation analysis, coined “contextual cocitation analysis,” is introduced and described in comparison to traditional methods of cocitation analysis. Equations for quantifying contextual cocitation strength are introduced and their implications explored using theoretical examples alongside the application of contextual cocitation to a series of BioMed Central publications and their cited resources. Based on this work, the implications of contextual cocitation for understanding the granularity of the relationships created between cited published research and methods for its analysis are discussed. Future applications and improvements of this work, including its extended application to the published research of multiple disciplines, are then presented with rationales for their inclusion.
Testing an integrative theoretical model of knowledge‐sharing behavior in the context of Wikipedia
Authors: Cho Hichang , Chen MeiHui , Chung Siyoung 
Published: March 2010

AbstractThis study explores how and why people participate in collaborative knowledge‐building practices in the context of Wikipedia. Based on a survey of 223 Wikipedians, this study examines the relationship between motivations, internal cognitive beliefs, social‐relational factors, and knowledge‐sharing intentions. Results from structural equation modeling (SEM) analysis reveal that attitudes, knowledge self‐efficacy, and a basic norm of generalized reciprocity have significant and direct relationships with knowledge‐sharing intentions. Altruism (an intrinsic motivator) is positively related to attitudes toward knowledge sharing, whereas reputation (an extrinsic motivator) is not a significant predictor of attitude. The study also reveals that a social‐relational factor, namely, a sense of belonging, is related to knowledge‐sharing intentions indirectly through different motivational and social factors such as altruism, subjective norms, knowledge self‐efficacy, and generalized reciprocity. Implications for future research and practice are discussed.
Computers, systems theory, and the making of a wired hospital: A history of Technicon Medical Information System, 1964–1987
Authors: Plotnick Rachel 
Published: March 2010

AbstractThis paper investigates the controversy surrounding the systems approach in medicine, contributing to the body of literature on systems and information technology in civilian contexts. Specifically, the paper follows the design and implementation of a hospital information system at El Camino Hospital in Mountain View, California, in the 1960s and 1970s. The case study suggests that while many considered “people problems” like healthcare too complex for the systems approach, in fact it could have positive results if system engineers could translate social concerns about medicine into business and organizational strategies. This paper identifies the ways systems designers approached an organization characterized by autonomy rather than collaboration, craft rather than science, and charity rather than business, and helped to redefine that organization as one that emphasized rationality, efficiency, and the coexistence of man and machine.
Trajectory of risky decision making for potential gains and losses from ages 5 to 85
Authors: Weller Joshua A. , Levin Irwin P. , Denburg Natalie L. 
Published: March 2010

AbstractThe ability to make advantageous decisions in the face of uncertainty is an essential human skill, yet the development of such abilities over the lifespan is still not well understood. In the current study, from childhood through older adulthood, we tracked the developmental trajectory of risk taking for gains and losses, and expected value (EV) sensitivity in risky choices. In the gain domain, risk‐taking decreased consistently across the lifespan. In the loss domain, risk‐taking was relatively constant across ages, a result we attribute to the pervasiveness of loss aversion. EV sensitivity showed an inverted‐U‐shaped function, increasing from childhood to adulthood but then decreasing for the elderly, which occurred for both risky gains and risky losses. This finding is consistent with neuropsychological and neuroanatomical evidence concerning the role of the frontal lobe in decision making, which is relatively late to develop during childhood but may degrade earlier in the later years. Copyright © 2010 John Wiley & Sons, Ltd.
Insertion of multiple α‐amino γ‐lactam (Agl) residues into a peptide sequence by solid‐phase synthesis on synphase lanterns
Authors: Ronga Luisa , Jamieson Andrew G. , Beauregard Kim , Quiniou Christiane , Chemtob Sylvain , Lubell William D. 
Published: March 2010

AbstractThe insertion of lactams into peptide analogs can enhance potency and improve receptor selectivity. The synthesis of lactam‐bridged peptide sequences has been accomplished by a solid‐phase approach on SynPhase lanterns using cyclic (R)‐ and (S)‐oxathiazinane ester (2) to annulate the amino lactam residue onto the peptide chain. Parallel synthesis of α‐amino γ‐lactam analogs of the allosteric modulator of IL‐1 receptor 101.10 (D‐Arg‐D‐Tyr‐D‐Thr‐D‐Val‐D‐Glu‐D‐Leu‐D‐Ala: rytvela) was performed by split‐mix chemistry on the lanterns. In particular, the double insertion of α‐amino γ‐lactams in the same peptide sequence has been accomplished by this effective method for the solid‐supported combinatorial synthesis of lactam‐bridged peptides. Peptides bearing an Agl residue exhibited curve shapes indicative of turn conformations in their circular dichroism spectra. © 2010 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 94: 183–191, 2010.
C‐type natriuretic peptide: Structural studies, fragment synthesis, and preliminary biological evaluation in human osteosarcoma cell lines
Authors: Shaikh Nasrin , Russo Laura , Papaleo Elena , Giannoni Paolo , De Gioia Luca , Nicotra Francesco , Quarto Rodolfo , Cipolla Laura 
Published: March 2010

AbstractNatriuretic peptides (NP) are a family of structurally related but genetically distinct hormones/paracrine factors that regulate blood volume, blood pressure, ventricular hypertrophy, pulmonary hypertension, fat metabolism, and long bone growth. In this work we present computational structural analysis of the three human NP in solution, the synthesis and preliminary biological assays of a short fragment of CNP, I14GSM17, together with one small mimetic, GGSM. Synthetic peptides IGSM, GGSM, and full length CNP were preliminary tested for their ability to influence cell growth of three human osteosarcoma cell lines. Synthetic peptides were shown to successfully mimic the biological activity of the full length natural peptide: their effects, although different upon the cell types used, are in accordance with the current literature, designating a possible role for CNP, and its derivatives, in skeletogenesis. © 2010 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 94: 213–219, 2010.
Ralph F. Hirschmann award address 2009: Merger of organic chemistry with peptide diversity
Authors: Meldal Morten , Tornøe Christian W. , Nielsen Thomas E. , Diness Frederik , Le Quement Sebastian T. , Christensen Christian A. , Jensen Jakob Feldthusen , Worm‐Leonhard Kasper , Groth Thomas , Bouakaz Lamine , Wu Boqian , Hagel Grith , Keinicke Lise 
Published: March 2010

AbstractA huge unleashed potential lies hidden in the large and diverse pool of encoded and particularly nonencoded chiral α‐, β‐, and γ‐amino acids available today. Although these have been extensively exploited in peptide science, the community of organic chemistry has only used this source of diversity in a quite focused and targeted manner. The properties and behavior of peptides as functional molecules in biology are well documented and based on the ability of peptides to adapt a range of discrete conformers at a minimal entropic penalty and therefore ideally fitting their endogenous targets. The development of new organic reactions and chemistries that in a general and quantitative way transform peptides into new functional molecules, preferably on solid support, is a source of completely new classes of molecules with important and advantageous functional properties. The peptide diversity and the ability to perform chemistry on solid support add tremendously to the combinatorial scope of such reactions in pharmaceutical and materials screening scenario. In recent years, the need for “click” reactions to shape complex molecular architecture has been realized mainly with a basis in the world of peptides and DNA, and in polymer chemistry where connection of highly functionalized biologically active substances or property bearing fragments are assembled as molecular LEGO® using quantitative and orthogonal click chemistries. In this article, three such new reactions originating in the Carlsberg Laboratory over the last decade taking advantage of organic transformations in the peptide framework is presented. Initially, the click reaction between azide and terminal alkynes catalyzed by Cu(1) (CuAAC‐reaction) is described. This CuAAC “click” reaction was observed first at Carlsberg Laboratory in reactions of azido acid chlorides with alkynes on solid support. Second, the Electrophilic Aromatic Substitution Cyclization–Intramolecular Click‐Cascade (EASCy‐ICC) reaction will be presented. This quantitative stereo‐selective cascade reaction provides a highly diverse set of interesting novel scaffolds from peptides. Finally, we describe the preparation of solid phase peptide phosphine‐ and carbene‐based green catalysts (organozymes), which upon complex formation with transition metal perform with high turnovers under aqueous conditions. These catalysts thrive from the peptide folding and diversity, while phosphines and carbenes in the backbone provide for bidental complex formation with transition metals in a format providing an excellent entry into combinatorial catalyst chemistry. © 2010 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 94: 161–182, 2010.
Semi‐automated microwave‐assisted SPPS: Optimization of protocols and synthesis of difficult sequences
Authors: Pedersen Søren L. , Sørensen Kasper K. , Jensen Knud J. 
Published: March 2010

AbstractPrecise microwave heating has emerged as a valuable addition to solid‐phase peptide synthesis. New methods and protocols are required to utilize this potential and make it a reliable technique. Here, we describe a new semi‐automated instrument for solid‐phase peptide synthesis with microwave heating and report protocols for its reliable use. The instrument features a flow‐through reaction vessel that is placed in the microwave instrument throughout the synthesis. Bubbling with N2 gas during the microwave irradiation proved important for temperature control. Washing and Fmoc removal steps were automated, while activated Fmoc‐amino acids were added manually. Several linkers and resins were evaluated and protocols for synthesis of difficult sequences were developed. These included on‐resin reductive amination of BAL handles under microwave heating. We believe that the instrument, as well as the protocols for its use, will be useful tools for peptide chemists. © 2010 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 94: 206–212, 2010.
N‐acyliminium intermediates in solid‐phase synthesis
Authors: Le Quement Sebastian T. , Petersen Rico , Meldal Morten , Nielsen Thomas E. 
Published: March 2010

AbstractN‐Acyliminium ions are powerful intermediates in synthetic organic chemistry. Examples of their use are numerous in solution‐phase synthesis, but there are unmerited few reports on these highly reactive electrophiles in solid‐phase synthesis. The present review covers the literature to date and illustrates the methods used to generate N‐acyliminium intermediates on solid support and their further elaboration to a range of pharmacologically interesting peptidomimetics, heterocycles, and other small molecules. © 2010 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 94: 242–256, 2010.
Amino acid derived 1,4‐dialkyl substituted imidazolones
Authors: Diness Frederik , Meldal Morten 
Published: March 2010

AbstractA general method for synthesis of 1,4‐substituted imidazolones from amino acids on solid support or in solution has been developed. Amino acid derived 3‐Boc‐(1,3)‐oxazinane (Box) protected amino aldehyde building blocks were coupled through urea bonds to the amino terminal of dipeptides or amino acids. Upon acidic release, the aldehyde instantaneously formed the cyclic N‐carbamyliminium ion, which rearranged to the corresponding imidazolone. Under strongly acidic conditions the imidazolones acted as nuclophiles in the Pictet‐Spengler reaction. © 2010 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 94: 236–241, 2010.
Efficient access to peptidyl ketones and peptidyl diketones via C‐alkylations and C‐acylations of polymer‐supported phosphorus ylides followed by hydrolytic and/or oxidative cleavage
Authors: El‐Dahshan Adeeb , Ahsanullah  , Rademann Jörg 
Published: March 2010

AbstractNovel syntheses of peptidyl ketones and peptidyl diketones on polymer support are described. Peptidyl phosphoranylidene acetates were prepared via C‐acylation of polymer‐supported phosphorus ylides. Selective alkylation of the ylide carbon with various alkyl halides, such as methyl iodide and benzyl bromide was established. Peptidyl diketones were obtained by oxidative cleavage. Peptidyl ketones were furnished by hydrolysis of the peptidyl phosphorus ylides under either basic or acidic conditions. © 2010 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 94: 220–228, 2010.
Efficient synthesis of Fmoc‐protected phosphinic pseudodipeptides: Building blocks for the synthesis of matrix metalloproteinase inhibitors
Authors: Bhowmick Manishabrata , Sappidi Ravinder R. , Fields Gregg B. , Lepore Salvatore D. 
Published: March 2010

AbstractA convenient route for the synthesis of Fmoc‐protected phosphinic dipeptide building blocks is described. The protected amino acid isosteres benzyloxycarbonyl aminomethyl phosphinic acid (glycine surrogate), benzyl α‐isopropyl acrylate (valine surrogate), and benzyl α‐isobutyl acrylate (leucine surrogate) were synthesized starting from commercially available materials. Reaction of either the valine or leucine surrogate with bis(trimethylsilyl) phosphonite generated the pseudodipeptide bond. The synthesis concluded with an efficient one‐pot three‐step procedure involving a bis‐deprotection of the N‐ and C‐termini under catalytic hydrogenation conditions followed by selective capping of the N‐terminus with an Fmoc group to yield either Fmoc‐NHCH2PO(OAd)CH2CH(Pri)CO2H or Fmoc‐NHCH2PO(OAd)CH2CH(Bui)CO2H. © 2010 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 96: 1–3, 2011.
ChemInform Abstract: Mercury Dications: Linear Form Is More Stable than Aromatic Ring.
Authors: Hoeltzl Tibor , Nguyen Minh Tho , Veszpremi Tamas 
Published: March 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Atomistic Simulation for Disordered TbCu7‐Type Compounds SmCo7 and Sm(Co,T)7 (T: Ti, Ga, Si, Cu, Hf, Zr).
Authors: Li Yiyang , Shen Jiang , Chen Yi 
Published: March 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Structure, and Bonding of Ca2Ni3Ge2 and Comparison with CaNiGe, SrNi2Ge, and Ca3Ni3Si2.
Authors: Hlukhyy Viktor , Faessler Thomas F. 
Published: March 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Two Structurally Related Oxide Nitride Chalcogenides of the Lanthanoids: Tb3ONSe2 and La5O2NS4.
Authors: Lissner Falk , Strobel Sabine , Schleid Thomas 
Published: March 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ordering Phenomena in Complex Chalcogenides — The Showcase of A2In12Q19 (A: K, Tl, NH4; Q: Se, Te) and Pseudobinary In2Q3.
Authors: Kienle Lorenz , Schlosser Marc , Manos Manolis J. , Malliakas Christos D. , Duppel Viola , Reiner Christof , Deiseroth Hans‐Joerg , Kanatzidis Mercouri G. , Kelm Klemens , Simon Arndt 
Published: March 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Low‐Temperature Synthesis, Magnetic and Microwave Electromagnetic Properties of Substoichiometric Spinel Cobalt Ferrite Octahedra.
Authors: Fan Xi'an , Guan Jianguo , Cao Xiaofen , Wang Wei , Mou Fangzhi 
Published: March 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Phase Equilibria Study in Systems Tl—Pb(Nd)—Bi—Te New Phases of Variable Composition on the Base of Tl9BiTe6.
Authors: Babanly M. B. , Tedenac J.‐C. , Imamalieva S. Z. , Guseynov F. N. , Dashdieva G. B. 
Published: March 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Energy‐Conversion Properties of Vapor—Liquid—Solid‐Grown Silicon Wire‐Array Photocathodes.
Authors: Boettcher Shannon W. , Spurgeon Joshua M. , Putnam Morgan C. , Warren Emily L. , Turner‐Evans Daniel B. , Kelzenberg Michael D. , Maiolo James R. , Atwater Harry A. , Lewis Nathan S. 
Published: March 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Obtaining and Stability Verification of Superconducting Phases of the Nb—Al and Nb—Sn Systems by Mechanical Alloying and Low‐Temperature Heat Treatments.
Authors: Santos F. A. , Ramos A. S. , Santos C. , Rodrigues D. Jr. 
Published: March 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ln3[SiON3]O (Ln: La, Ce, Pr) — Three Oxonitridosilicate Oxides with Crystal Structures Derived from the anti‐Perovskite Structure Type.
Authors: Kechele Juliane A. , Schmolke Christian , Lupart Saskia , Schnick Wolfgang 
Published: March 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ln19(C2)3I34 (Ln: Y, Gd): Compounds with Discrete Ln6I12 Clusters and Isolated Ln Atoms.
Authors: Schaloske Manuel C. , Kienle Lorenz , Duppel Viola , Mattausch Hansjuergen , Simon Arndt 
Published: March 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: NDTB‐1: A Supertetrahedral Cationic Framework that Removes TcO4‐ from Solution.
Authors: Wang Shuao , Alekseev Evgeny V. , Diwu Juan , Casey William H. , Phillips Brian L. , Depmeier Wulf , Albrecht‐Schmitt Thomas E. 
Published: March 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: GeSb4Te4 — A New 9P‐Type Phase in the System Ge/Sb/Te.
Authors: Schneider Matthias N. , Oeckler Oliver 
Published: March 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Crystallized Zn3(VO4)2: Synthesis, Characterization and Optical Property.
Authors: Ni Shibing , Wang Xinghui , Zhou Guo , Yang Feng , Wang Junming , He Deyan 
Published: March 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.