bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hyperkinetic seizures in patients with temporal lobe epilepsy: Clinical features and outcome after temporal lobe resection
Authors: Staack Anke M. , Bilic Sofia , Wendling Anne‐Sophie , Scholly Julia , Kraus Uwe , Strobl Karl , Bodin Frédéric , Zentner Josef , Steinhoff Bernhard J. 
Published: May 2011

SummaryPurpose: Temporal lobe epilepsy (TLE) is usually associated with automatisms. Hyperkinetic seizures are supposed to be unusual. Because we witnessed several patients with TLE and ictal hyperkinetic symptoms, we retrospectively assessed the number, clinical findings, and seizure outcome in such patients who had undergone temporal lobe resection.Methods: We reviewed medical history, video–electroencephalography (EEG) recording and neuroimaging of adult patients who underwent epilepsy surgery for TLE at the Kork Epilepsy Center over the last 20 years with a minimum postoperative follow‐up of 12 months.Key Findings: Among 294 patients who were resected exclusively in the temporal region, we identified 17 (6%) who presented with hyperkinetic semiology such as violent vocalization, complex movements of the proximal segments of the limbs, rotation of the trunk, pelvic thrusting, or early tonic or dystonic posturing. Most of the patients had a preceding aura. Ictal EEG activity was located in the corresponding temporal region, usually with a wide distribution over temporal electrodes with fast spread to unilateral frontal electrodes and to the contralateral side. Neuroimaging revealed extended lesions in the temporal lobe involving mesial and neocortical structures. Most of the patients underwent classical anterior temporal lobe resection including amygdalo‐hippocampectomy. Fourteen patients (82%) became completely seizure‐free (Engel class Ia). Histopathology showed mainly focal cortical dysplasia plus hippocampal sclerosis.Significance: Hyperkinetic seizure semiology may occasionally occur in patients with TLE and is, therefore, no contradiction to the hypothesis of TLE if scalp EEG patterns and neuroimaging findings correspond. The postoperative seizure outcome is favorable in such patients and not different from outcome data in classical TLE.
Language deficits and altered hemispheric lateralization in young people in remission from BECTS
Authors: Monjauze Cécile , Broadbent Hannah , Boyd Stewart G. , Neville Brian G. R. , Baldeweg Torsten 
Published: May 2011

SummaryBenign epilepsy with centrotemporal spikes (BECTS) is associated with language disturbances during the active phase of the seizure disorder. However, it is not yet known whether these deficits are reversible or have long‐term impact on the development of language skills. We report on a study conducted in 13 patients in remission from BECTS and 13 age‐matched controls, who underwent neuropsychological assessments. We also recorded event‐related potentials (ERPs) during a verb generation task, to determine cortical lateralization of language. The BECTS group showed significant language deficits compared to controls as well as a pattern of atypical ERP lateralization in frontal regions. These findings support the view that BECTS in childhood may lead to enduring effects on brain maturation and language development.
Do U.S. Insurance Firms Offer the “Wrong” Incentives to Their Executives?
Authors: Milidonis Andreas , Stathopoulos Konstantinos 
Published: May 2011

AbstractWe examine the relation between executive compensation and market‐implied default risk for listed insurance firms from 1992 to 2007. Shareholders are expected to encourage managerial risk sharing through equity‐based incentive compensation. We find that long‐term incentives and other share‐based plans do not affect the default risk faced by firms. However, the extensive use of stock options leads to higher future default risk for insurance firms. We argue that this is because option‐based incentives induce managerial risk‐taking behavior, which seeks to maximize managerial payoff through equity volatility. This could be detrimental to the interests of shareholders, especially during a financial crisis.
Carotid Stenting in High‐Risk Patients: Early and Late Outcomes
Authors: GRIBAR JOHN J. , JIDDOU MONICA , CHOKSI NISHIT , ABBAS AMR E. , BOWERS TERRY , KAZMIERCZAK CHRIS , TIMMS CHRIS , SAFIAN ROBERT D. 
Published: May 2011

Purpose: Some patients with severe carotid stenosis have anatomical or clinical comorbidities that place them at high risk for carotid endarterectomy (CEA). The early and late outcomes after carotid artery stenting (CAS) were evaluated in patients at high risk for CEA.
Methods: Between 2002 and 2009, 186 patients were enrolled in a high‐risk CAS institutional registry. The primary outcome was major adverse cardiac and cerberovascular events (MACCEs) at 30 days, including death, stroke, and myocardial infarction. Secondary outcomes were technical, procedural, and clinical success; nonstroke neurological events; and death and ipsilateral stroke at 5 years.
Results: Twenty‐five patients (13.2%) were symptomatic. Thirty day MACCE occurred in 2.6%, including death in 1 (0.5%), stroke in 3 (1.6%), and myocardial infraction in 1 (0.5%) patient. Strokes were nonfatal in 3 (1.6%), major in 2 (1.1%), and minor in 1 (0.5%) patients. Other neurological events included transient ischemic attack in 9 (4.7%) and retinal artery occlusion in 2 (1.1%) patients. After stroke, 2 patients had complete resolution of neurological deficit within 30 days, and 1 patient had improvement in neurological deficit. By Kaplan–Meier analysis, all‐cause mortality was 47.5% and ipsilateral stroke was 4.5% at 5 years.
Conclusions: In patients who are high risk for CEA, CAS can be performed with low MACCE at 30 days and ipsilateral stroke at 5 years. However, nearly half of these patients die within 5 years from causes unrelated to stroke. (J Interven Cardiol 2011;24:247–253)
Salivary nitric oxide levels in inflammatory periodontal disease – A case‐control and interventional study
Authors: Parwani SR , Chitnis PJ , Parwani RN 
Published: May 2011

To cite this article:
Int J Dent Hygiene
10, 2012; 67–73  DOI: 10.1111/j.1601‐5037.2011.00508.x  Parwani SR, Chitnis PJ, Parwani RN. Salivary nitric oxide levels in inflammatory periodontal disease – A case‐control and interventional study.Abstract:  Background:  Biochemical markers of inflammatory periodontal disease present in saliva can partially determine the extent of periodontal disease. Furthermore, collection of salivary constituents is a simple and non‐invasive procedure. Nitric oxide (NO) has been linked to etiopathogenesis of inflammatory periodontal disease and is expressed in saliva. This study was conducted with the objective of estimating salivary NO levels in inflammatory periodontal diseases (gingivitis and periodontitis) and comparing these levels with control subjects. A re‐assessment of these levels was also made after providing appropriate treatment with a view to ascertain its diagnostic and prognostic values.Methods:  This was a case–control as well as an interventional study including a total of 90 (30 control, 30 gingivitis and 30 periodontitis) subjects. Saliva samples were collected from each subject, and NO levels were assayed by Griess reaction.Results:  NO levels were increased significantly in gingivitis and periodontitis subjects as compared with controls. There was a statistically significant decrease in the NO levels in each study group after the healing period (corresponding to the reduced clinical signs of inflammation). Our study also correlated probing pocket depths with salivary NO levels in periodontitis group where we found a positive correlation between the two.Conclusion:  Salivary NO levels can be utilized as a good indicator of the inflammatory status of the periodontium, and evaluating its levels in saliva by Griess reaction on a photoelectric colorimeter is a reliable, accurate and faster method to estimate the level of inflammation in periodontal tissues.
Dental hygienists as adult learners and educators to improve access to care
Authors: Rogo EJ 
Published: May 2011

To cite this article:

Int J Dent Hygiene
10, 2012; 36–45  DOI: 10.1111/j.1601‐5037.2011.00510.x  Rogo EJ. Dental hygienists as adult learners and educators to improve access to care.Abstract:  Objective:  The purpose of the qualitative study was to understand dental hygienists as adult learners and educators in their quest to improve access to care. The intent of this article is to share the results from open and focused coding procedures and the participants’ rich stories from which the analysis was constructed.Methods:  A grounded theory approach to data collection and analysis was used. Data were collected from eight practitioners in three US states who met the inclusion criteria, using semi‐structured interviews. Traditional grounded theory procedures with a constructivist emphasis on lived experiences of the participants and situational analysis were used to analyse the data.Results:  The process of learning was experienced in three categories: Awareness, Adaptation and Relationships. Awareness was the process of learning participants experienced as developing consciousness of self, status quo, power and injustice of systems. Adaptation was constructed from experiences of specializing and creating to adjust to the new environments and prepare future practitioners. Relationships were developed to feel connected and collaborate to build support and gain respect to improve access to care. Dental hygienists as educators revealed one category: Improvement. Improvement was the process of educating others to enhance awareness, oral health and the dental hygiene profession.Conclusions:  Dental hygienists were adult learners by using their experiences in the context of their struggle to improve health inequities. A strong educator role was necessary to make improvements in the oral health delivery system.
Biomedical Ti–Mo Alloys with Surface Machined and Modified by Laser Beam: Biomechanical, Histological, and Histometric Analysis in Rabbits
Authors: Oliveira Nilson T.C. , Guastaldi Fernando P.S. , Perrotti Vittoria , Hochuli‐Vieira Eduardo , Guastaldi Antonio C. , Piattelli Adriano , Iezzi Giovanna 
Published: May 2011

ABSTRACTPurpose: In vivo bone response was assessed by removal torque, hystological and histometrical analysis on a recently developed biomedical Ti‐15Mo alloy, after surface modification by laser beam irradiation, installed in the tibia of rabbits.Materials and Methods: A total of 32 wide cylindrical Ti‐15Mo dental implants were obtained (10 mm × 3.75 mm). The implants were divided into two groups: 1) control samples (Machined surface – MS) and 2) implants with their surface modified by Laser beam‐irradiation (Test samples – LS). Six implants of each surface were used for removal torque test and 10 of each surface for histological and histometrical analysis. The implants were placed in the tibial metaphyses of rabbits.Results: Average removal torque was 51.5 Ncm to MS and >90 Ncm to LS. Bone‐to‐implant‐contact percentage was significantly higher for LS implants both in the cortical and marrow regions.Conclusions: The present study demonstrated that laser treated Ti‐15Mo alloys are promising materials for biomedical application.
The association between renal function and tooth loss in Japanese community‐dwelling postmenopausal women
Authors: Yoshihara Akihiro , Nakamura Kazutoshi , Miyazaki Hideo 
Published: May 2011

doi: 10.1111/j.1741‐2358.2011.00481.x

The association between renal function and tooth loss in Japanese community‐dwelling postmenopausal womenObjectives:  This study examined whether low renal function is associated with the number of remaining teeth among community‐dwelling elderly Japanese.Background data:  Many elderly individuals display both low renal function and tooth loss.Materials and Methods:  Subjects comprised 405 randomly selected women (55–74 years old). Serum cystatin C level was used to assess renal dysfunction. Multiple linear regression analysis was used to evaluate the relationship between number of remaining teeth and serum cystatin C level, with number of remaining teeth as the dependent variable. Six variables were selected as independent variables in the final model: serum cystatin C; age; mean clinical attachment level; serum cross‐linked N‐telopeptide of type I collagen level; body mass index and smoking habits.Results:  Multiple linear regression analysis revealed a significant relationship between number of remaining teeth and serum cystatin C level. The beta value for serum cystatin C level for the number of remaining teeth was −0.11 (p = 0.018).Conclusion:  This study indicates a relationship between serum cystatin C level and number of remaining teeth, suggesting that low renal function could be associated with tooth loss.
A cross‐sectional study of oral health and oral health‐related quality of life among frail elderly persons on admission to a special oral health care programme in Copenhagen City, Denmark
Authors: Christensen Lisa Bøge , Hede Børge , Nielsen Ellen 
Published: May 2011

doi: 10.1111/j.1741‐2358.2011.00486.x

A cross‐sectional study of oral health and oral health‐related quality of life among frail elderly persons on admission to a special oral health care programme in Copenhagen City, DenmarkAim:  To describe the oral health and the oral‐health‐related quality of life (OHRQoL) of citizens in Copenhagen City on admission to a specific oral health‐care programme for disabled elderly persons. Further, to analyse how various factors influence the oral health and the OHRQoL among these patients.Methods:  A cross‐sectional study of 189 persons (average 85 years) consecutively admitted to a special oral health‐care programme. Clinical data and data from interviews comprising social factors, life‐style, dental visit habits, oral hygiene practices and self‐perceived oral health were collected. A modified index on perceived dysfunction, discomfort and disability due to oral disorders was used.Results:  Sixty‐eight per cent had natural teeth, among those 57% had decayed teeth and two out of three wore dentures. Smoking habits influence the number of teeth present and the OHRQoL (p < 0.05) of the patients. Edentulousness, decayed teeth, and presence of dentures did not seem to cause OHRQoL problems, while higher OHRQoL scores (more problems) were reported by those with 1–9 teeth and tooth mobility.Conclusion:  OHRQoL of these patients can be increased by removal of loose teeth and provision of dentures to those with very few teeth rather than focus on traditional caries treatment.
Novel association of multiple gastrointestinal anomalies in a single patient: Can Sonic Hedgehog explain it?
Authors: Rathod Kirtikumar J. , Vaze Dhananjay , Narasimhan Kannan L. 
Published: May 2011

ABSTRACTThe occurrence of four gastrointestinal (GIT) anomalies in a single patient is extremely rare. Only one report of four GIT anomalies in a child has been published in the English literature. The current report presents a child with four anomalies and discusses the molecular mechanisms which control the development of the gastrointestinal tract.
D‐strand perturbation and amyloid propensity in beta‐2 microglobulin
Authors: Azinas Stavros , Colombo Matteo , Barbiroli Alberto , Santambrogio Carlo , Giorgetti Sofia , Raimondi Sara , Bonomi Francesco , Grandori Rita , Bellotti Vittorio , Ricagno Stefano , Bolognesi Martino 
Published: May 2011

Proteins hosting main β‐sheets adopt specific strategies to avoid intermolecular interactions leading to aggregation and amyloid deposition. Human beta‐2 microglobulin (β2m) displays a typical immunoglobulin fold and is known to be amyloidogenic in vivo. Upon severe kidney deficiency, β2m accumulates in the bloodstream, triggering, over the years, pathological deposition of large amyloid aggregates in joints and bones. A β‐bulge observed on the edge D β‐strand of some β2m crystal structures has been suggested to be crucial in protecting the protein from amyloid aggregation. Conversely, a straight D‐strand, observed in different crystal structures of monomeric β2m, could promote amyloid aggregation. More recently, the different conformations observed for the β2m D‐strand have been interpreted as the result of intrinsic flexibility, rather than being assigned to a functional protective role against aggregation. To shed light on such contrasting picture, the mutation Asp53→Pro was engineered in β2m, aiming to impair the formation of a regular/straight D‐strand. Such a mutant was characterized structurally and biophysically by CD, X‐ray crystallography and MS, in addition to an assessment of its amyloid aggregation trends in vitro. The results reported in the present study highlight the conformational plasticity of the edge D‐strand, and show that even perturbing the D‐strand structure through a Pro residue has only marginal effects on protecting β2m from amyloid aggregation in vitro.Database
Atomic coordinates and structure factors have been deposited in the Protein Data Bank under the accession number 3NA4.Structured digital abstract
Beta‐2‐microglobulin binds to Beta‐2‐microglobulin by fluorescence technology (View interaction)
Beta‐2‐microglobulin binds to Beta‐2‐microglobulin by mass spectrometry studies of complexes (View Interaction 1, 2, 3)
Beta‐2‐microglobulin binds to Beta‐2‐microglobulin by electron microscopy (View interaction)
9-Hydroxycanthin-6-One Induces Penile Erection and Delays Ejaculation
Authors: Chiou Wen-Fei , Wu Tian-Shung 
Published: May 2011

ABSTRACT

Introduction
Eurycoma longifolia Jack (Simaroubaceae) has the reputation as a male aphrodisiac because it is claimed to increase virility and sexual prowess. Nevertheless, whether or not E. longifolia regulates directly the muscle tone of corpus cavernosa and/or seminal vesicle (SV) remains unclear. Even until now, the compositions that could account for its aphrodisiac property are still unknown

Aim
We examined the effect of 9-hydroxycanthin-6-one (9-HC-6-one), a β-carboline alkaloid isolated from E. longifolia, on penile erection and ejaculation, and further elucidated the mechanism of action.

Main Outcome Measures
9-HC-6-one induces penile erection and delays ejaculation.

Methods
Drug’s effect was studied on rat corpus cavernosum (CC) and SV in vitro, and on the changes in intracavernosal pressure (ICP) after IC injection and intraluminal pressure (ILP) of the SV after hypogastric nerve stimulation (HNS), respectively.

Results
9-HC-6-one relaxed significantly phenylephrine (PE)-precontracted CC. Such response was not attenuated by endothelium disruption, NG-nitro-L-arginine methyl ester, or 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one treatment, suggesting that a nitric oxide/cyclic guanosine monophosphate-dependent pathway was precluded. 9-HC-6-one attenuated PE-induced contraction by blocking cell surface and internal calcium channels with a higher potency for internal calcium release. This compound also antagonized calcium-evoked contraction in Ca2+-free, high K+-depolarizing condition, suggesting that interfering with the entry of calcium through voltage-dependent channels also contributed to 9-HC-6-one-induced corporal relaxation. After IC application of 9-HC-6-one, a significant rise in ICP was observed as compared with the application of normal saline. 9-HC-6-one relaxed significantly norepinephrine (NE)- and KCl-precontracted SV, and antagonized NE-induced oscillatory contraction as potent as clomipramine. Finally, the HNS-evoked increase in ILP was dose-dependently repressed after challenge by 9-HC-6-one.

Conclusion
9-HC-6-one might be the active component that contributed to the aphrodisiac effect of E. longifolia by antagonizing the smooth muscle tone of CC as well as SV probably through interfering with Ca2+ mobilization.
The False Diagnosis of Venous Leak: Prevalence and Predictors
Authors: Teloken Patrick E. , Park Kelly , Parker Marilyn , Guhring Patricia , Narus Joseph , Mulhall John P. 
Published: May 2011

ABSTRACT

Introduction
As a vascular test, dynamic infusion cavernosometry (DIC) has lost popularity, and in the urologic community, penile duplex Doppler ultrasound (DUS) has become the sole test to investigate a vascular etiology of erectile dysfunction. Vasoactive agent redosing has been shown to increase the accuracy of DUS.

Aim
To define the erectile hemodynamics in men with previously diagnosed venous leak on DUS.

Methods
Prospective data were collected on patients who (i) had been given a diagnosis of venous leak based on an outside DUS; (ii) elected to undergo a repeat DUS; and (iii) when the repeat DUS suggested venous leak, underwent DIC.

Main Outcome Measures
DUS: peak systolic velocity and end-diastolic velocity. DIC: flow to maintain.

Results
292 patients were included. Mean ± standard deviation age was 44 ± 26 years. On repeat DUS, 19% (56/292) had completely normal hemodynamics and 7% (20/292) had arterial insufficiency only without venous leak. DIC revealed normal hemodynamics in 13% (38/292), while in 58% (152/292) of patients, the venous leak diagnosis was confirmed. Overall, 47% (137/292) of patients who had been given a diagnosis of venous leak had completely normal hemodynamics, and in only 43% (126/292), the venous leak diagnosis was confirmed upon repeat vascular testing. On multivariable analysis, younger age (&lt;45 years), failure to obtain an adequate erection during the original DUS, and having &lt;2 vascular risk factors were predictive of a false diagnosis of venous leak.

Conclusions
Penile DUS has a propensity to inaccurately assign a diagnosis of venous leak. Great care should be taken when performing DUS especially in younger men without a significant vascular risk factor history, and the failure to obtain a good erection should make the clinician cautious in assigning a diagnosis of venous leak. Furthermore, there still exists a role for cavernosometry, which appears to have a greater accuracy at diagnosing venous leak.
Abscisic Acid Receptors: Past, Present and FutureF
Authors: Guo Jianjun , Yang Xiaohan , Weston David J. , Chen Jin‐Gui 
Published: May 2011

Abstract Jin‐Gui Chen (Corresponding author) Abscisic acid (ABA) is the key plant stress hormone. Consistent with the earlier studies in support of the presence of both membrane‐ and cytoplasm‐localized ABA receptors, recent studies have identified multiple ABA receptors located in various subcellular locations. These include a chloroplast envelope‐localized receptor (the H subunit of Chloroplast Mg2+‐chelatase/ABA Receptor), two plasma membrane‐localized receptors (G‐protein Coupled Receptor 2 and GPCR‐type G proteins), and one cytosol/nucleus‐localized Pyrabactin Resistant (PYR)/PYR‐Like (PYL)/Regulatory Component of ABA Receptor 1 (RCAR). Although the downstream molecular events for most of the identified ABA receptors are currently unknown, one of them, PYR/PYL/RCAR was found to directly bind and regulate the activity of a long‐known central regulator of ABA signaling, the A‐group protein phosphatase 2C (PP2C). Together with the Sucrose Non‐fermentation Kinase Subfamily 2 (SnRK2s) protein kinases, a central signaling complex (ABA‐PYR‐PP2Cs‐SnRK2s) that is responsible for ABA signal perception and transduction is supported by abundant genetic, physiological, biochemical and structural evidence. The identification of multiple ABA receptors has advanced our understanding of ABA signal perception and transduction while adding an extra layer of complexity.