bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of DPP-4 with Vildagliptin Improved Insulin Secretion in Response to Oral as well as “Isoglycemic” Intravenous Glucose without Numerically Changing the Incretin Effect in Patients with Type 2 Diabetes
Authors: Vardarli Irfan , Nauck Michael A. , Köthe Lars D. , Deacon Carolyn F. , Holst Jens J. , Schweizer Anja , Foley James E. 
Published: January 2011

AbstractBackground and Aims:Dipeptidyl peptidase-4 (DPP-4) inhibitors block the degradation of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide. The aim of the present study was to quantitatively assess the incretin effect after treatment with the DPP-4 inhibitor vildagliptin (V) or placebo (P) in patients with type 2 diabetes.Materials and Methods:Twenty-one patients (three women, 18 men) with type 2 diabetes previously treated with metformin (mean age, 59 yr; body mass index, 28.6 kg/m2; glycosylated hemoglobin, 7.3%) were studied in a two-period crossover design. They received 100 mg V once daily or P for 13 d in randomized order. The incretin effect was measured on d 12 (75-g oral glucose) and d 13 (“isoglycemic” iv glucose) based on insulin and C-peptide determinations and insulin secretion rates (ISR).Results:V relative to P treatment significantly increased intact incretin concentrations after oral glucose and insulin secretory responses to both oral glucose and isoglycemic iv glucose (e.g. AUCISR oral, by 32.7%, P = 0.0006; AUCISR iv, by 33.1%, P = 0.01). The numerical incretin effect was not changed (IEISR, V vs. P, 35.7 ± 4.9 and 34.6 ± 4.0%, P = 0.80).Conclusions:DPP-4 inhibition augmented insulin secretory responses both after oral glucose and during isoglycemic iv glucose infusions, with no net change in the incretin effect. Thus, slight variations in basal incretin levels may be more important than previously thought. Or, DPP-4 inhibitor-induced change in the incretin-related environment of islets may persist overnight, augmenting insulin secretory responses to iv glucose as well. Alternatively, yet unidentified mediators of DPP-4 inhibition may have caused these effects.
Managed Care, Drug Benefits and Mortality: An Analysis of the Elderly
Authors: Gowrisankaran Gautam , Town Robert , Barrette Eric 
Published: January 2011

Abstract
We evaluate the impact of the Medicare HMO program and prescription drug coverage on elderly mortality using data from 1993 to 2000. We specify a model of plan entry and benefit choice and Medicare enrollee plan choice and health outcomes. We derive an estimator that is consistent with endogenous plan selection by using the quasi-experimental variation caused by peculiarities of the Medicare reimbursement system for HMOs. We find that, relative to traditional Medicare, enrollment in an HMO without drug coverage increases mortality while enrollment in an HMO with drug coverage has no significant impact. The economic value of the reduction in mortality from drug coverage far outweighs the costs. HMOs, those without drug coverage in particular, attract healthier enrollees than average.
Comparison of surgical variables and short-term postoperative complications in healthy dogs undergoing ovariohysterectomy or ovariectomy
Authors: Peeters Marijke E. , Kirpensteijn Jolle 
Published: January 2011

Abstract
Objective—To determine whether ovariohysterectomy (OVH) required more time to complete and was associated with more short-term postoperative complications than ovariectomy (OVE) in dogs.
Design—Randomized prospective clinical trial.
Animals—40 healthy, sexually intact female dogs.
Procedures—OVH (in 20 dogs) or OVE (20 dogs) was performed by use of standardized anesthetic and surgical protocols. Physical characteristics of the dogs, surgical variables, pain scores derived from behavior-based composite pain scales, and surgical wound characteristics were analyzed.
Results—Body weight, age, body condition score, and distance between the sternal manubrium and the pubic rim were comparable among dogs that underwent either surgical procedure. Body weight was positively correlated with the total duration of the procedure and with time required for closure of the surgical wound. No effect of body condition score was determined for any variable. Skin and fascia incision lengths relative to the distance from the sternal manubrium to pubic rim were significantly greater in dogs that underwent OVH, compared with those of dogs that underwent OVE, but total surgical time was not different for the 2 procedures. No other significant differences were detected between the 2 groups.
Conclusions and Clinical Relevance—Significant differences in total surgical time, pain scores, and wound scores were not observed between dogs that underwent OVH and dogs that underwent OVE via standardized protocols.
Clinical progression of X-linked muscular dystrophy in two German Shorthaired Pointers
Authors: Olby Natasha J. , Sharp Nick J. H. , Nghiem Peter E , Keene Bruce W. , DeFrancesco Teresa C. , Sidley Jennifer A. , Kornegay Joe N. , Schatzberg Scott J. 
Published: January 2011

Abstract
Case Description—2 full-sibling male German Shorthaired Pointer (GSHP) puppies (dogs 1 and 2) with X-linked muscular dystrophy and deletion of the dystrophin gene (gene symbol, DMD) each had poor growth, skeletal muscle atrophy, pelvic limb weakness, episodic collapse, and episodes of coughing.
Clinical Findings—Initial examination revealed stunted growth, brachygnathism, trismus, and diffuse neuromuscular signs in each puppy; clinical signs were more severe in dog 2 than in dog 1. Immunohistochemical analysis revealed a lack of dystrophin protein in both dogs. During the next 3 years, each dog developed hyperinflation of the lungs, hypertrophy of the cervical musculature, and hypertrophy of the lateral head of the triceps brachii muscle.
Treatment and Outcome—Monitoring and supportive care were provided at follow-up visits during an approximately 7-year period. No other specific treatment was provided. Neuromuscular signs in both dogs remained stable after 3 years of age, with dog 2 consistently more severely affected than dog 1. The dogs had multiple episodes of aspiration pneumonia; dogs 1 and 2 were euthanatized at 84 and 93 months of age, respectively.
Clinical Relevance—The clinical course of disease in these dogs was monitored for a longer period than has been monitored in previous reports of dystrophin-deficient dogs. The clinical progression of muscular dystrophy in the 2 GSHPs was compared with that for other breeds and species with dystrophin-deficient conditions, and the potential basis for the phenotypic variation observed between these littermates, along with potential therapeutic ramifications for dogs and humans, was evaluated.
Retroperitoneal pyogranulomatous and fibrosing inflammation secondary to fungal infections in two dogs
Authors: Clemans Jessica M. , Deitz Krysta L. , Riedesel Elizabeth A. , Yaeger Michael J. , Legendre Alfred M. 
Published: January 2011

Abstract
Case Descriptions—A 4-year-old spayed female Golden Retriever (dog 1) was examined because of acute edema and erythema in the left hind limb and an inguinal mass, and a 5-year-old female Jack Russell Terrier (dog 2) was examined because of a recurring retro-peritoneal mass.
Clinical Findings—Dog 1 had an edematous, hyperemic left hind limb with a fixed inguinal mass. Monocytic neutrophilic leukocytosis and hypoalbuminemia were detected. Diagnostic imaging revealed abnormal tissue surrounding the larger vessels and ureters and complete occlusion of the left limb veins. Surgery resulted in incomplete removal of the mass. Histologic examination revealed fibrosing pyogranulomatous inflammation. Results of a Histoplasma antigen test were positive, and reanalysis of the tissues revealed yeast cells indicative of Histoplasma capsulatum. Dog 2 had incomplete removal of a retroperitoneal mass. Histologic examination revealed fibrosing pyogranulomatous inflammation. The mass recurred 8 months later in dog 2; exploratory abdominal surgery at that time resulted in substantial hemorrhage from the adhered caudal aorta. Histologic examination of tissue sections from the second surgery revealed yeast cells consistent with Blastomyces dermatitidis.
Treatment and Outcome—Both dogs had temporary improvement after surgery. Full clinical resolution required treatment for fungal disease. Dog 1 was treated with itraconazole, then fluconazole (total treatment time, 23 weeks). Dog 2 was treated with fluconazole for 36 weeks.
Clinical Relevance—Retroperitoneal pyogranulomatous fibrosis caused by fungal infections has not been reported in veterinary medicine. There was substantial morbidity, but the prognosis can be good when this abnormality is recognized and antifungal medications are administered.
Nouvelle note sur la chronologie du règne de Jean Cantacuzène
Authors: Failler Albert 
Published: January 2011

REB 34 1976 France p. 119-124
A. Failler, Nouvelle note sur la chronologie du règne de Jean Cantacuzène. — Seul un colophon du Laurentianus 85-6 (f. 2) précisait jusqu'à présent la date du retour de Jean V Paléologue à Constantinople après son exil à Ténédos (22 novembre 1354). Une notice du Parisinus graecus 753 (f. 118v-19) fournit une date différente (29 novembre 1354) et plus plausible, si l'on se fie au récit de l'historien Cantacuzène, les deux colophons s'accordant d'autre part sur le jour de la vêture monastique de Jean Cantacuzène (10 décembre 1354), dont l'abdication doit donc être fixée au 9 décembre 1354.
Notes on the last years of John Palaiologos, brother of Michael VIII
Authors: Magdalino Paul 
Published: January 2011

REB 34 1976 France p. 143-149
P. Magdalino, Notes on the last years of John Palaiologos, brother of Michael VIII. — The Despot John Palaeologus fell into disgrace after the Battle of Neopatras. A brief chronicle situates his death between 1272 and 1273. The « Despot John » mentioned by Gregory of Cyprus in 1284 is therefore not the brother of Michael VIII. He should rather be identified with John Asen of Bulgaria. Some cartulary acts of Makritinissa contribute further evidence in favour of dating the Battle of Neopatras and the disgrace of John Palaeologus between November 1272 and October 1273.
La chronologie de la dynastie avare de Baïan
Authors: Olajos Thérèse 
Published: January 2011

REB 34 1976 France p. 151-158
Thérèse Olajos, La chronologie de la dynastie avare de Baïan. — En examinant attentivement les sources, et en particulier Y Histoire de Théophy lacté Simocatta, on peut établir que Baïan était khagan des Avars de 562 à 582 ; peut-être le devint-il quelques années auparavant (en 558 au plus tôt) et le resta-t-il un ou deux ans de plus. La succession échut à son fils aîné, puis au cadet, qui garda le pouvoir jusque vers 630.
Un recueil de lettres faussement attribué à Michel Psellos
Authors: Gautier Paul 
Published: January 2011

REB 35 1977 France p. 99-106
P. Gautier, Un recueil de lettres faussement attribué à Michel Psellos. — L'auteur présente et édite (sans traduction ni résumé) huit courtes lettres transmises sous le nom de Psellos dans le Vindobonensis philol. gr. 321. De l'analyse de leur contenu et du lemme de la lettre 9 (non éditée et réservée pour une publication ultérieure) il ressort que ce recueil épistolaire lui a été faussement attribué par le copiste.
The Basilika and the Demosia. The Financial Offices of the Late Byzantine Empire
Authors: Miller Timothy 
Published: January 2011

REB 36 1978 France p. 171-191
T. Miller, The Basilika and the Demosia. — In the fourth book of his History the emperor John VI Cantacuzenus states that the Galata War of 1349 had been financed from two state treasuries, the basilika and the demosia. In other passages the emperor refers to these same two treasuries. His language suggests two central financial offices in the structure of the late Byzantine bureaucracy, but many students of Byzantine history have detected only one, what they call the bestiarion. This article examines some of the documents of the Palaeologan period to prove that there were surely two separate financial offices and that this distinction was rooted in bureaucratic tradition and in the method of land classification. The study concludes with some observations on the significance of the financial offices in the decline of the Byzantine state and on their role in encouraging opposition to the aristocratic movement of John Cantacuzenus.
Notes sur quatre documents d'ecclésiologie byzantine
Authors: Karlin-Hayter Patricia 
Published: January 2011

REB 37 1979 France p. 249-258
Patricia Karlin-Hayter, Notes sur quatre documents d'ecclésiologie byzantine. — A propos d'un ouvrage de J. Darrouzès (Documents inédits d'ecclésiologie byzantine, Paris 1966), l'auteur fait quelques remarques sur les élections épiscopales à Byzance. Ces observations portent sur les écrits respectifs d'Euthyme de Sardes sur les élections épiscopales, d'un anonyme sur les prérogatives des métropolites, de Nicétas d'Amasée à propos d'une querelle survenue au patriarcat à cause des votes d'élection, de Nicétas d'Ancyre sur les élections.
La restauration et la chute définitive de Tralles au 13e siècle
Authors: Failler Albert 
Published: January 2011

REB 42 1984 France p. 249-263
A. Failler, La restauration et la chute définitive de Tralles au 13e siècle. — La restauration de la forteresse de Tralles par Andronic II Palaiologos est présentée comme le haut fait de la jeunesse de l'empereur, tant par les historiens (Georges Pachymérès et Nicéphore Grègoras) que par ses panégyristes (Georges de Chypre et Théodore Métochitès). Relevée en 1280, la forteresse fut assiégée et prise par les Turcs en 1283 ou 1284. De la confrontation et de la contradiction des divers textes, on peut déduire qu 'Andronic Il naquit en 1258, vers le temps où son père Michel Palaiologos commençait sa marche vers le pouvoir.
A missing chapter from the typikon of Nikephoros Blemmydes
Authors: Munitiz Joseph A. 
Published: January 2011

REB 44 1986 France p. 199-207
J. A. Munitiz, A missing chapter from the typikon of Nikephoros Blemmydes. — The edition with English translation and notes of the text of a chapter mentioned by A. Heisenberg but not published by him along with the other three chapters that have survived from the foundation document of Blemmydes ; the sole manuscript (Monac. gr. 225) is described and the relation analysed between this chapter and a section of Blemmydes' Autobiography (written in 1265), in which he reproduces a eucharistie discourse delivered before the Armenian delegates who visited Nymphaion in 1249/1250.
L'église des Ancônitains à Constantinople
Authors: Failler Albert 
Published: January 2011

REB 44 1986 France p. 253-255
A. Failler, L'église des Ancônitains à Constantinople. — R. Janin a mentionné l'existence d'une église Saint-Étienne des Ancônitains à Constantinople, mais la source alléguée par lui ne dit rien de tel. Il reste néanmoins qu'une église d'e ce nom existait bien, comme le confirme un texte du 14e siècle, les Statuti del Mare d'Ancône.
Pseudo-Psellos : Graecorum opiniones de daemonibus
Authors: Gautier Paul 
Published: January 2011

REB 46 1988 France p. 85-107
P. Gautier, Pseudo-Psellos : Graecorum opiniones de daemonibus. — Édition et commentaire d'un opuscule attribué à Psellos et traitant, d'après le titre, des opinions des Grecs sur les démons. Il s'agit en fait d'un écrit composite, divisé en huit sections et touchant différents thèmes. Il s'inspire de diverses sources, dont le De daemonibus du Pseudo-Psellos, qu'il démarque parfois littéralement. L'édition est basée sur le texte du Vatican, gr. 1411, f . 33-34v.
Infantry versus Cavalry : The Byzantine Response
Authors: McGeer Eric 
Published: January 2011

REB 46 1988 France p. 135-145
E. McGeer, Infantry versus Cavalry : The Byzantine Response. — This article reviews the battle tactics prescribed by the author of the Praecepta Militaria (ca. 965) for the use of infantry facing cavalry. This text and set of tactics were chosen for study because of the light they shed on the author's efforts to combine the recommendations of earlier military textbooks (especially the Sylloge Tacticorum, ca. 950) with his own expertise in developing and presenting his defensive system. The development of infantry tactics did not end with the Praecepta, however, for the second version of this work included in the Tactica of Nikephoros Ouranos (ca. 1000) shows us that further adjustments were deemed necessary in order to maintain the shifting balance between infantry and cavalry throughout the later tenth century.
Chronologie et composition dans l'Histoire de Georges Pachymérès (livres VII-XIII)
Authors: Failler Albert 
Published: January 2011

REB 48 1990 France p. 5-87
A. Failler, Chronologie et composition dans l'Histoire de Georges Pachymérès (livres VII-VIIΙ). — La seconde partie de l'Histoire, qui couvre les années 1282-1307, présente moins de problèmes de chronologie que la première, et le récit se déroule de manière plus linéaire. Certaines questions exigent cependant d'être traitées plus longuement que ne le permettra la nouvelle édition. Voici les points qui sont successivement examines : 1. Les étapes de la vie troublée de Michel Komnènos, le fils de .lean le Bâtard le sébastokratôr de Thessalie ; 2 et 3. Le séjour d Andronic II en Bithynie et à Nymphée dans les années 90, avec la visite rendue à cette occasion à Jean Laskaris et à Jean Bekkos sur le chemin de Taller; 1. La révolte d'Alexis Philanthrôpènos et son aveuglement ; 5. Le séjour d' Andronic II à Thessalonique à l'occasion (tes fiançailles de Simonis avec le kral de Serbie ; 6. La visite du patriarche Jean à l'empereur un peu avant sa démission; 7. La première expédition militaire de Michel IX et ses revers en Asie ; 8, 9 et 10. Les campagnes de la Compagnie catalane en Asie et en Europe de 1304 à 1307.
Trois documents de la controverse gréco-arménienne
Authors: Darrouzès Jean 
Published: January 2011

REB 48 1990 France p. 89-153
J. Darrouzès, Trois documents de la controverse gréco-arménienne. — Ces textes inédits sont publiés avec une traduction française et une introduction ; ils ne sont pas datables avec précision à cause de leur anonymat. Le premier est une lettre patriarcale au catholicos, qui contient une réfutation des erreurs attribuées aux Arméniens; le second est une profession de foi trinitaire et christologique adressée à l'empereur Jean Comnène par un catholicos, sans doute drégoire III; le troisième donne le catalogue des usages blâmables dont l'Église byzantine exigeait la réforme avant d'accepter la communion avec les Arméniens, vers les années 1172-1180.
Three Notes on the Iconography of Dionysius the Areopagite
Authors: Walter Christopher 
Published: January 2011

REB 48 1990 France p. 255-274, 8 pl.
Ch. Walter, Three Notes on the Iconography of Dionysius the Areopagite. — Three themes in the iconography of Dionysius are elucidated with the aid of the apocryphal literary sources. The significance of the miniature of Dionysius's vision of the Crucifixion is explained by referring it to the account of it in his autobiography. The identity of the bishops represented in scenes of the Dormition is established more precisely by a study of the accounts of the event in both the mariological homilies and the lives of Dionysius and by a study of the portrait types of the bishops. Finally the iconographical theme of Dionysius's céphalophorie is shown to be Eastern in origin although the legend itself was a Western creation. It is also shown to be distinct from the iconography of other saints 'kephalophoroi'.
Assessment of Subclinical Vascular Disease Associated with Ankylosing Spondylitis
Authors: BODNÁR NÓRA , KEREKES GYÖRGY , SERES ILDIKÓ , PARAGH GYÖRGY , KAPPELMAYER JÁNOS , NÉMETHNÉ ZSUZSANNA GYURCSIK , SZEGEDI GYULA , SHOENFELD YEHUDA , SIPKA SÁNDOR , SOLTÉSZ PÁL , SZEKANECZ ZOLTÁN , SZÁNTÓ SÁNDOR 
Published: January 2011

Objective.Studies indicate that ankylosing spondylitis (AS), as well as rheumatoid arthritis, may be associated with accelerated atherosclerosis and vascular disease. We assessed endothelial dysfunction, carotid atherosclerosis, and aortic stiffness in AS in context with clinical and laboratory measurements.Methods.Forty-three patients with AS and 40 matched healthy controls were studied. We assessed common carotid intima-media thickness (ccIMT), flow-mediated vasodilation (FMD), and pulse-wave velocity (PWV) in association with age, disease duration, smoking habits, body mass index, patient’s assessment of pain and disease activity, Bath AS Disease Activity Index, Bath AS Functional Index (BASFI), metric measurements, erythrocyte sedimentation rate, C-reactive protein, and HLA-B27 status.Results.We found impaired FMD (6.85 ± 2.98% vs 8.30 ± 3.96%; p = 0.005), increased ccIMT (0.65 ± 0.15 vs 0.54 ± 0.15 mm; p = 0.01), and higher PWV (8.64 ± 2.44 vs 8.00 ± 1.46 m/s; p = 0.03) in patients with AS compared to controls, respectively. We also found that ccIMT negatively correlated with FMD (r = −0.563; p = 0.0001) and positively correlated with PWV (r = 0.374; p = 0.018). Both ccIMT and PWV correlated with disease duration (r = 0.559; p = 0.013 and r = 0.520; p = 0.022, respectively), BASFI (r = 0.691; p = 0.003 and r = 0.654; p = 0.006), decreased lumbar spine mobility (r = −0.656; p = 0.006 and r = −0.604; p = 0.013), chest expansion (r = −0.502; p = 0.047 and r = −0.613; p = 0.012), and increased wall-occiput distance (r = 0.509; p = 0.044 and r = 0.614; p = 0.011).Conclusion.In this well characterized AS population, impaired FMD and increased ccIMT and PWV indicate abnormal endothelial function and increased atherosclerosis and aortic stiffness, respectively. The value of noninvasive diagnostic tools needs to be further characterized.
Early Prediction of Increased Arterial Stiffness in Patients with Chronic Inflammation: A 15-year Followup Study of 108 Patients with Rheumatoid Arthritis
Authors: PROVAN SELLA A. , ANGEL KRISTIN , SEMB ANNE GRETE , MOWINCKEL PETTER , AGEWALL STEFAN , ATAR DAN , KVIEN TORE K. 
Published: January 2011

Objective.Patients with rheumatoid arthritis (RA), a chronic inflammatory disease, have increased cardiovascular morbidity and mortality. We investigated whether early markers of RA inflammatory disease activity could predict later increased levels of pulse-wave velocity (PWV) and augmentation index (AIx), 2 measures of arterial stiffness.Methods.In total 238 patients with early RA were followed longitudinally and 108 were available for the 15-year followup examination. Comprehensive baseline clinical and radiographic data were collected in 1992. Arterial stiffness, measured as AIx and PWV (Sphygmocor apparatus), was recorded at the 15-year followup. Adjusted logistic univariate and multivariate analyses were performed with levels of AIx and PWV as the dependent variables, and variables reflecting baseline RA disease activity as possible predictors. The validity of the final models was examined in linear regression analyses.Results.Baseline C-reactive protein (CRP) above the median predicted increased AIx (OR 3.52, 95% CI 1.04–11.90) and PWV (OR 4.84, 95% CI 1.39–16.83) at the 15-year assessment in multivariate models. Patients with elevated baseline CRP had significantly higher AIx (ß = 2.67, 95% CI 0.06–5.31, p = 0.045) and lnPWV (ß = 0.08, 95% CI 0.01–0.14, p = 0.02) after 15 years, after adjustments for age, sex, heart rate (AIx only) and mean arterial pressure.Conclusion.Inflammation early in the RA disease course was associated with increased AIx and PWV after 15 years. These findings support the importance of early control of the inflammatory process in patients with RA.