bluuebunny/crossref_metadata_2025_split huggingface dataset:
Socioeconomic status and health disparities drive differences in accelerometer-derived physical activity in fatty liver disease and significant fibrosis
Authors: Tabacu Lucia , Swami Sajag , Ledbetter Mark , Siddiqui Mohamad S. , Smirnova Ekaterina 
Published: May 2024

Background and aimsThe cornerstone of clinical management of patients with nonalcoholic fatty liver disease (NAFLD) are lifestyle changes such as increasing physical activity (PA) aimed at improving cardiometabolic risk. To inform NAFLD prevention and treatment guidelines we aimed to: (i) quantify the role of PA on lowering the risk for NAFLD and fibrosis; (ii) characterize NAFLD and fibrosis association with PA in the context of socioeconomic environment.MethodsA sample of 2648 participants from the NHANES 2003–2006 was selected to develop survey weighted multivariable logistic regression models for predicting NAFLD and significant fibrosis, diagnosed non-invasively via fatty liver index (FLI) and fibrosis-4 (FIB-4) index. The PA measures were obtained from a hip-worn accelerometer.ResultsThe predictive model for NAFLD showed AUC of 0.687 and a decrease of 43% in NAFLD risk with moderate vigorous PA (MVPA) (OR = 0.569, p < 0.001). The predictive model for fibrosis had AUC of 0.755 and there was a 48% and a 70% decrease in significant fibrosis risk with MVPA (OR = 0.518, p = 0.022) and total log activity count (TLAC) (OR = 0.296, p = 0.017), respectively. Participants with NAFLD and NAFLD with fibrosis engage in declining PA. Despite having jobs with higher level of PA and participating in more moderate-to-vigorous PA, a larger proportion of Hispanics participants had NAFLD and significant fibrosis.ConclusionsThese findings demonstrate the role of PA as a protective factor against the presence of NAFLD and significant fibrosis. Protective levels of PA in NAFLD differ by races.
Study protocol to examine the effects of acute exercise on motor learning and brain activity in children with developmental coordination disorder (ExLe-Brain-DCD)
Authors: Busquets Albert , Ferrer-Uris Blai , Durduran Turgut , Bešlija Faruk , Añón-Hidalgo Manuel , Angulo-Barroso Rosa 
Published: May 2024

Introduction
Developmental coordination disorder (DCD) is one of the most prevalent pediatric chronic conditions. Without proper intervention, significant delays in motor skill performance and learning may persist until adulthood. Moderate-to-vigorous physical exercise has been proven to improve motor learning (adaptation and consolidation) in children with or without disorders. However, the effect of a short bout of physical exercise on motor adaptation and consolidation in children with DCD has not been examined. Furthermore, the role of perceptual-motor integration and attention as mediators of learning has not been examined via neuroimaging in this population.

Objectives
Therefore, the primary aims of this project will be to compare children with and without DCD to (a) examine the effect of acute exercise on motor learning (adaptation and consolidation) while performing a rotational visuo-motor adaptation task (rVMA), and (b) explore cortical activation in the dorsolateral- and ventrolateral-prefrontal cortex areas while learning the rVMA task under rest or post-exercise conditions.

Methods
One hundred twenty children will be recruited (60 DCD, 60 controls) and within-cohort randomly assigned to either exercise (13-minute shuttle run task) or rest prior to performing the rVMA task. Adaptation and consolidation will be evaluated via two error variables and three retention tests (1h, 24h and 7 days post adaptation). Cortical activation will be registered via functional near-infrared spectroscopy (fNIRS) during the baseline, adaptation, and consolidation.

Discussion
We expect to find exercise benefits on motor learning and attention so that children with DCD profiles will be closer to those of children with typical development. The results of this project will provide further evidence to: (a) better characterize children with DCD for the design of educational materials, and (b) establish acute exercise as a potential intervention to improve motor learning and attention.
Co-construct, implement and evaluate a multi-level intervention to prevent a sedentary lifestyle in children—Study protocol of the CIPRES study
Authors: Carayol Marion , Laujac Steven , Cholley-Gomez Marie , Franceschi Josselin , Rozand Axel , Pallier Laurence , Estrella Jean-Pierre , Vanhierde Bruno , Guillet-Descas Emma , Damville Emmanuel , Gavarry Olivier , Delpierre Cyrille 
Published: May 2024

Background
A sedentary lifestyle is commonly associated with a higher risk of chronic disease development. Among school-aged children from European countries, screen-time represents a significant portion of sedentary time with 39.8% of children spending more than 2h/day in front of a screen on average. Therefore, effective solutions to reduce sedentary behavior (SB) must be found. Multilevel interventions based on the socio-ecological model (SEM) are particularly relevant to take into account influences of the social environment on individuals’ SB. Moreover, the trans-contextual model (TCM) can offer complementary levers for individuals’ behavior change. The CIPRES study is a theory-based multilevel intervention designed to decrease the SB in French primary school children aged 8–10 years. The present paper describes the protocol of a randomized controlled study to evaluate the effectiveness of the CIPRES multilevel intervention on SB.

Methods
The CIPRES study is a cluster-randomized controlled trial comparing intervention vs control groups. A total of 700 children are targeted for inclusion, distributed in four municipalities considered as clusters. The study consists of two successive phases: 1) co-building of a SB prevention intervention by using a participatory approach involving representatives of each level of the SEM (e.g., children, parents, staff from municipalities, teachers) and 2) implementation and evaluation of the intervention. The intervention will last for 6 weeks in each involved class. Primary outcome will be the sedentary time of children per week, assessed by accelerometry. In addition, children and their parents will be asked to fill out questionnaires concerning children’s physical activity level, screen time, quality-of-life and variables of the TCM.

Discussion
This study will give information on the effectiveness of a theory-based intervention, involving multiple levels of actors in the co-construction and the implementation of the intervention, that may interest schools and public health officers looking for innovative sedentary prevention programs.
Comprehensive analysis of early T cell responses to acute Zika Virus infection during the first epidemic in Bahia, Brazil
Authors: Samri Assia , Bandeira Antonio Carlos , Gois Luana Leandro , Silva Carlos Gustavo Regis , Rousseau Alice , Corneau Aurelien , Tarantino Nadine , Maucourant Christopher , Queiroz Gabriel Andrade Nonato , Vieillard Vincent , Yssel Hans , Campos Gubio Soares , Sardi Silvia , Autran Brigitte , Rios Grassi Maria Fernanda 
Published: May 2024

Background
In most cases, Zika virus (ZIKV) causes a self-limited acute illness in adults, characterized by mild clinical symptoms that resolve within a few days. Immune responses, both innate and adaptive, play a central role in controlling and eliminating virus-infected cells during the early stages of infection.

Aim
To test the hypothesis that circulating T cells exhibit phenotypic and functional activation characteristics during the viremic phase of ZIKV infection.

Methods
A comprehensive analysis using mass cytometry was performed on peripheral blood mononuclear cells obtained from patients with acute ZIKV infection (as confirmed by RT-PCR) and compared with that from healthy donors (HD). The frequency of IFN-γ-producing T cells in response to peptide pools covering immunogenic regions of structural and nonstructural ZIKV proteins was quantified using an ELISpot assay.

Results
Circulating CD4+ and CD8+ T lymphocytes from ZIKV-infected patients expressed higher levels of IFN-γ and pSTAT-5, as well as cell surface markers associated with proliferation (Ki-67), activation ((HLA-DR, CD38) or exhaustion (PD1 and CTLA-4), compared to those from HD. Activation of CD4+ and CD8+ memory T cell subsets, including Transitional Memory T Cells (TTM), Effector Memory T cells (TEM), and Effector Memory T cells Re-expressing CD45RA (TEMRA), was prominent among CD4+ T cell subset of ZIKV-infected patients and was associated with increased levels of IFN-γ, pSTAT-5, Ki-67, CTLA-4, and PD1, as compared to HD. Additionally, approximately 30% of ZIKV-infected patients exhibited a T cell response primarily directed against the ZIKV NS5 protein.

Conclusion
Circulating T lymphocytes spontaneously produce IFN-γ and express elevated levels of pSTAT-5 during the early phase of ZIKV infection whereas recognition of ZIKV antigen results in the generation of virus-specific IFN-γ-producing T cells.
Effects of different nutrition interventions on sarcopenia criteria in older people: A study protocol for a systematic review of systematic reviews with meta-analysis
Authors: Ferreira Luis Fernando , Roda Cardoso Jéssica , Telles da Rosa Luis Henrique 
Published: May 2024

Background
Sarcopenia, a subject of extensive research, has led to numerous clinical trials and systematic reviews (SR). These reviews aid healthcare professionals by summarizing results and conducting meta-analyses, enhancing reliability. However, the abundance of reviews complicates decision-making on sarcopenia management. To address this, SR of SR have emerged, consolidating data from various sources into comprehensive documents.

Objective
To assess the isolated impact of dietary interventions on sarcopenia’s diagnostic criteria for older individuals.

Methods
A study protocol for a SR of SR, following Cochrane and PRISMA recommendations. The search strategy includes the MeSH ‘sarcopenia’ and its subheadings; ‘aged’ and its subheadings; ‘nutrition’ and its subheadings; and filter ‘systematic review’, performed at main databases. Selected studies must include older adults, submitted to nutritional interventions compared to control groups. Quantitative analyses will use inverse variance statistic method (random effects); the effect measures mean difference. Heterogeneity measured with Q-Test.

Results
The results of this SR of SR may provide valuable information about the sarcopenia treatment, deepening the knowledge about.

Conclusion
This protocol is reproducible, requires low cost and personnel, and may allow a higher understanding on sarcopenia treatment and management on older people.
Clinical effectiveness of drop-in mental health services at paediatric hospitals: A non-randomised multi-site study for children and young people and their families – study protocol
Authors: Roach Anna , Bennett Sophie , Heyman Isobel , Coughtrey Anna , Stokes Isabella , Ndoci Xhorxhina , Balakrishnan Sonia , Astle Nicki , Drinkwater Jessie , Evans Rebecca , Frederick Una , Groszmann Michael , Jones Steve , McDonnell Katie , Mobley Amanda , Murray Abbie , O’Sullivan Helena , Ormrod Sarah , Prendegast Theodore , Rajalingam Usha , Webster Emily , Webster Rebecca , Vinton Gareth , Shafran Roz 
Published: May 2024

Background
Despite the high prevalence of mental health difficulties in children and young people with long-term health conditions (LTCs), these difficulties and experiences are often overlooked and untreated. Previous research demonstrated the effectiveness of psychological support provided via a drop-in mental health centre located in a paediatric hospital. The aim of this prospective non-randomised single-arm multi-centre interventional study is to determine the clinical effectiveness of drop-in mental health services when implemented at paediatric hospitals in England.

Methods
It is hypothesised that families who receive psychological interventions through the drop-in services will show improved emotional and behavioural symptoms. Outcomes will be measured at baseline and at 6-month follow-up. The primary outcome is the difference in the total difficulties score on the Strengths and Difficulties Questionnaire (SDQ) reported by parent or child at 6 months. Secondary outcomes include self and parent reported Paediatric Quality of Life Inventory (PedsQL), self-reported depression (PHQ-9) and anxiety measures (GAD-7) and family satisfaction (CSQ-8).

Discussion
This trial aims to determine the clinical effectiveness of providing psychological support in the context of LTCs through drop-in mental health services at paediatric hospitals in England. These findings will contribute to policies and practice addressing mental health needs in children and young people with other long-term health conditions.

Trial registration
ISRCTN15063954, Registered on 9 December 2022.
A brief instrument measuring the water, sanitation and hygiene domain of menstrual health among women who inject drugs
Authors: Calderón-Villarreal Alhelí , Avelar Portillo Lourdes Johanna , Abramovitz Daniela , Goldenberg Shira , Flanigan Shawn , Quintana Penelope J. E. , Harvey-Vera Alicia , Vera Carlos F. , Rangel Gudelia , Strathdee Steffanie A. , Kayser Georgia L. 
Published: May 2024

Background
Domains of adequate menstrual health (MH) include access to water, sanitation, and hygiene (WASH). People who menstruate with social disadvantages—such as homelessness or drug injection practices–often face barriers to WASH access. However, validated instruments to measure MH are limited among marginalized populations, and available instruments involve lengthy surveys. We developed and evaluated psychometric properties of a novel ‘MH WASH Domain Scale-12’ among people who menstruate and who inject drugs in the Tijuana–San Diego region and identified correlates of MH access using this scale.

Methods
We constructed a MH-scale based on access to twelve WASH-related items: (1) menstrual products, (2) body hygiene (bathing per week), (3) water sources for bathing, (4) improved, (5) non-shared, (6) available, (7) private, (8) nearby, (9) and safe sanitation facilities, (10) availability of soap, (11) water source for handwashing, and (12) handwashing facilities with soap/water. Variables were dichotomized and summed, with scores ranging from 0–12 points and higher scores indicating better MH access. We assessed the scale’s reliability and construct and content validity using data from a binational cross-sectional study. The sample included people who inject drugs (PWID) who had ever menstruated in their lifetime and were 18+ during 2020–2021. MH-WASH items were described, and the scale was further used as an outcome variable to identify correlates.

Results
Among 125 (124 cis-female and 1 trans-male) PWID that reported menstruating, our ‘MH WASH Domain Scale-12’ was reliable (Cronbach’s alpha = 0.81, McDonald’s Omega total = 0.83) and valid. We identified two sub-domains: Factor-1 included items describing ‘WASH availability’ and Factor-2 contained items related to ‘WASH security’—encompassing physical and biological safety. Scale scores were significantly lower among participants experiencing unsheltered homelessness compared to participants experiencing sheltered homelessness or living in permanent housing.

Conclusion
We constructed and validated a novel and reliable scale to measure MH-related WASH access that can be used to assess MH among marginalized populations in English- and Spanish-speaking contexts. Using this scale we identified disparities in MH-WASH access among PWID and who menstruate in the US-Mexico border region.
Spontaneous Coronary Artery Dissection in a Male Patient With Fibromuscular Dysplasia
Authors: Schneider Artur , Gharacholou S. Michael 
Published: May 2024

Abstract
A male patient presented with cardiac arrest attributed to anterior ST-segment elevation myocardial infarction from type 1 spontaneous coronary artery dissection. Subsequent imaging confirmed fibromuscular dysplasia in noncoronary arterial segments. The patient was started on guideline-directed medical therapy and referred to cardiac rehabilitation, showing substantial improvements in clinical status. With greater awareness and advancements in imaging, spontaneous coronary artery dissection has been more frequently recognized, and although as many as 81% to 92% of all cases occur in female patients, it can be seen among men, as well. Adjunctive imaging for arteriopathies may help establish the diagnosis for equivocal causes of acute coronary syndrome in women and men.
Diurnal and day-to-day biological variation of salivary cortisol and cortisone
Authors: Danese Elisa , Padoan Andrea , Negrini Davide , Paviati Elisa , De Pastena Matteo , Esposito Alessandro , Lippi Giuseppe , Montagnana Martina 
Published: May 2024

Abstract

Objectives
There is a growing interest in the relevance of salivary cortisol and cortisone concentrations in stress-related research. To correctly attribute the magnitude of salivary cortisol and cortisone variation as an effect of a stressful event, a coherent understanding of the day-to-day intra-individual and inter-individual variability across the diurnal cycle of the two steroids is required. However, such information is currently lacking.

Methods
This study aimed to overcome these existing limitations by performing an investigation of the biological variation (BV) of salivary cortisol and cortisone within one day and between five days using an LC-MS/MS method. Saliva samples were collected from 20 healthy volunteers immediately after waking up, at 8:00, 12:00, 15:00, 19:00 and 23:00 on each day over five days. All samples were analyzed in duplicate in one run. Nested ANOVA was used to calculate the sums of squares for analytical and biological components of variation.

Results
The within-subject BV of salivary cortisol and cortisone (CVI) ranged from a minimum of 29.3 and 19.0 % to a maximum of 56.5 and 49.1 %, respectively, while the between-subject biological variation (CVG) ranged from 29.7 and 29.0 % to 51.6 and 43.6 %. The reference change values (RCVs) ranged from 96 to 245 % for cortisol and from 55 to 194 % for cortisone. A medium index of individuality was observed for both compounds at all time points.

Conclusions
This study provides updated BV estimates and RCVs for different times of day that can be used to assess the magnitude of change in biomarkers in future stress-related research.
Revisiting the nature and the context of T4 alternations: insights from disyllabic, trisyllabic and quadrisyllabic word/digit productions in Taiwan Mandarin
Authors: Liu Chin-Ting 
Published: May 2024

Abstract
The tone values of a Tone 4 (T4) syllable are conventionally assumed to change from ‘51’ to ‘53’ when the syllable is followed by another T4 syllable in Mandarin Chinese. Literature focusing on T4 alternation is still inconclusive regarding the contexts for the alternations and whether the phenomenon should be better categorized as tone sandhi (i.e., represented as an abstract phonological rule in mental grammar) or tonal coarticulation (i.e., a natural articulation phenomenon at the phonetic level). The current study probes into these issues by focusing on disyllabic pseudowords, right-branching trisyllabic words as well as unstructured trisyllabic and quadrisyllabic digits. Productions from a total of 148 participants were collected and fundamental frequency (f0) contours, vowel lengths and f0 slopes were included in the analysis. The results from the experiments supported the tonal coarticulation view and showed that the trigger for the alternations was the high-onset tones following T4. Implications to the phonological analysis on tonal alternations in Mandarin Chinese are discussed.
Perioperative Health Interventions in Children With Chronic Neuromuscular Conditions Undergoing Major Musculoskeletal Surgery: A Scoping Review
Authors: Giordano Mirna , Casavant David , Flores Cano Juan Carlos , Rempel Gina , Dorste Anna , Graham Robert J. , Quates Sara K. , Belthur Mohan V. , Bastianelli Lucia C. , Sewell Taylor B. , Zamkoff Jason , Mauskar Sangeeta , Mariani Juliana , Trost Margaret J. , Simpson Blair , Stringfellow Isabel , Berry Jay G. 
Published: May 2024

BACKGROUND AND OBJECTIVES
Children with chronic neuromuscular conditions (CCNMC) have many coexisting conditions and often require musculoskeletal surgery for progressive neuromuscular scoliosis or hip dysplasia. Adequate perioperative optimization may decrease adverse perioperative outcomes. The purpose of this scoping review was to allow us to assess associations of perioperative health interventions (POHI) with perioperative outcomes in CCNMC.

METHODS
Eligible articles included those published from January 1, 2000 through March 1, 2022 in which the authors evaluated the impact of POHI on perioperative outcomes in CCNMC undergoing major musculoskeletal surgery. Multiple databases, including PubMed, Embase, Cumulative Index of Nursing and Allied Health Literature, Web of Science, the Cochrane Library, Google Scholar, and ClinicalTrials.gov, were searched by using controlled vocabulary terms and relevant natural language keywords. Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guidelines were used to perform the review. A risk of bias assessment for included studies was performed by using the Risk of Bias in Non-randomized Studies of Interventions tool.

RESULTS
A total of 7013 unique articles were initially identified, of which 6286 (89.6%) were excluded after abstract review. The remaining 727 articles’ full texts were then reviewed for eligibility, resulting in the exclusion of 709 (97.5%) articles. Ultimately, 18 articles were retained for final analysis. The authors of these studies reported various impacts of POHI on perioperative outcomes, including postoperative complications, hospital length of stay, and hospitalization costs. Because of the heterogeneity of interventions and outcome measures, meta-analyses with pooled data were not feasible.

CONCLUSIONS
The findings reveal various impacts of POHI in CCNMC undergoing major musculoskeletal surgery. Multicenter prospective studies are needed to better address the overall impact of specific interventions on perioperative outcomes in CCNMC.
On the Provenance of Field Reports of the 1886 Charleston, South Carolina, Earthquake: A Seismo-Historical Whodunnit
Authors: Hough Susan E. , Bilham Roger 
Published: May 2024

Abstract
Much of what is known about the effects of the 1886 Charleston, South Carolina, earthquake throughout the epicentral region can be attributed to meticulous field investigations by an individual with training in geology and engineering, Earle Sloan (Clendenin, 1926). In a recent study, Bilham and Hough (2024) undertook a detailed analysis of the effects of the earthquake on railroads in the Charleston region, drawing heavily from Sloan’s reports. This exercise identified several inconsistencies in Sloan’s field reports, including understandable measurement imprecision, inferred data entry mistakes, and transcription errors. The study also begged the question, where was Sloan at the time of the mainshock and over the following week? And to what extent did he draw from secondhand information in compiling his reports? On this question Sloan’s reports were sometimes enigmatic, lending themselves to misinterpretation in contemporaneous as well as modern interpretations. Beyond the details that were germane for, and briefly summarized by, the studies of Bilham and Hough (2023, 2024), in this report we don our historical seismologist caps to chronicle Sloan’s activities following the earthquake. We summarize our inferences here for the benefit of future scholars who might attempt to retrace either Sloan’s footsteps or our own. This study also serves to highlight Sloan’s singular contributions to earthquake science, which were never published separately.