bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐pressure Raman spectra of tuite, γ‐Ca3(PO4)2
Authors: Zhai Shuangmeng , Wu Xiang , Ito Eiji 
Published: October 2009

AbstractThe Raman spectra of a synthetic tuite, γ‐Ca3(PO4)2, have been measured up to 23.6 GPa using a diamond‐anvil cell at room temperature. The data were collected during compression and decompression. No pressure‐induced phase transformation was observed in this pressure range. The behaviors of the phosphate modes and the external modes under high pressures were analyzed. The Raman wavenumbers of all modes increased linearly and continuously with pressure. The pressure coefficients of the phosphate modes range from 0.0034 to 0.0049 GPa−1 for ν3, 0.0044 GPa−1 for ν1, from 0.0020 to 0.0033 GPa−1 for ν4, and 0.0037 GPa−1 for ν2, whereas the pressure coefficients of the external modes range from 0.0120 to 0.0138 GPa−1. The corresponding Grüneisen parameters are 0.341–0.491, 0.441, 0.200–0.331 and 0.371 for the phosphate modes ν3, ν1, ν4 and ν2, respectively, and from 1.20 to 1.38 for the external modes. Copyright © 2009 John Wiley & Sons, Ltd.
Thymidine phosphorylase to dihydropyrimidine dehydrogenase ratio as a predictive factor of response to preoperative chemoradiation with capecitabine in patients with advanced rectal cancer
Authors: Boskos C.S. , Liacos C. , Korkolis D. , Aygerinos K. , Lamproglou I. , Terpos E. , Stoupa E. , Baltatzis G. , Beroukas K. , Papasavvas P. , Dimopoulos M.A. , Bamias A. 
Published: October 2009

AbstractPurposeTo identify if thymidine phosphorylase (TP), dihydropyrimidine dehydrogenase (DPD), and ratio TP/DPD levels in tumor tissues are potential predictive factors for response to combined preoperative chemoradiation with capecitabine, in patients with locally advanced rectal cancer (LARC).Methods And PatientsBetween 2004 and 2006, 28 patients with LARC (cT2‐T4, N0–N2) were treated with neoadjuvant chemoradiation. Total radiation dose was 50.4 Gy and daily dose was 1.8 Gy in 5.5 weeks. Capecitabine was administrated 1,650 mg/m2/day, 7 days/week. Preoperative staging was based on combined computer tomography and endorectal ultrasound. Tissue samples, both neoplastic and normal ones, were endoscopically taken before treatment for TP and DPD measurement with ELISA. Levels of total proteins were calculated by the Bradford method.ResultsMedian TP, DPD, ratio TP/DPD levels in the primary tumors were 32.85 U/mg, 18.73 U/mg, and 1.64 respectively. Median ratio TP/DPD of patients with proven pathological “response” (downstaging of the disease) was higher than the “no response” group, 4.40 and 1.42, respectively (P = 0.0001). Levels of TP and DPD in tumor tissue did not reveal any statistically important difference between the two groups.ConclusionsTP/DPD ratio is a possible predictive factor for tumor response after concomitant preoperative chemoradiation with capecitabine in LARC. J. Surg. Oncol. 2010;102:408–412. © 2009 Wiley‐Liss, Inc.
Histopathological and immunohistochemical evaluations of breast cancer treated with radiofrequency ablation
Authors: Motoyoshi Ai , Noguchi Masakuni , Earashi Mitsuharu , Zen Yoh , Fujii Hisatake 
Published: October 2009

AbstractBackgroundAlthough RF ablation is a promising non‐surgical ablation technique for the treatment of breast cancer, assessment of the efficacy requires not only imaging of tumor necrosis but also histological confirmation.MethodsTwo series of patients were treated with RF ablation. In the first series, 17 patients underwent surgical resection immediately and 17 underwent delayed mammotome excision in the second series. The ablated tumor tissue was examined histologically with H&E staining and NADH‐diaphorase staining. Furthermore, ssDNA was immunohistochemically stained in the specimen where tumor cells were histologically detected.ResultsIn the first series, mild response was histologically seen in 14 of 17 patients (82%), whereas complete response was observed in 8 of 16 patients (50%) in the second series. However, NADH‐diaphorase staining did not demonstrate any viable tumor tissues in any patient in either the first or the second series. ssDNA staining was positive (non‐viable) in 13 of 16 cases in the first series, but it was positive in all 8 cases tested in the second series.ConclusionAlthough NADH‐diaphorase staining is essential to evaluate tumor cell viability immediately after RF ablation, ssDNA may be useful for the assessment of cell viability after some interval following RF ablation. J. Surg. Oncol. 2010;102:385–391. © 2009 Wiley‐Liss, Inc.
Use of gemini surfactants as semipermanent capillary coatings in aqueous‐organic solvents for capillary electrophoretic separation of inorganic anions
Authors: Liu Qian , Li Yanqing , Yao Lihua , Yao Shouzhuo 
Published: October 2009

AbstractThis paper proposes a new method for CE separation of inorganic anions based on the use of gemini surfactants as capillary coatings in mixed aqueous‐organic solvents. The semipermanent gemini surfactant coatings were facilely prepared by rinsing the capillary with 18‐s‐18 solutions; they can keep be stable during the electrophoretic runs without surfactants in buffer. The coatings showed a good tolerance of methanol (MeOH) or ACN, e.g. at pH 8.0 and with 40% v/v MeOH or ACN, the EOF magnitude after 60 min of continuous electrokinetic rinsing only decreased by 2.9 or 6.0%, respectively. The coatings were successfully applied to the separation of inorganic anions. Adding organic solvents in buffer can effectively improve the resolution and efficiencies; however, it remarkably prolonged the analysis time due to the suppression of EOF. Interestingly, varying the spacer length of the gemini surfactants can also modulate (improve) the resolution but without any sacrifice of analysis time. This benefit was resulted from the unique chemical structures of gemini surfactants because it introduced a new variable, i.e. the spacer length, to the separation mechanism.
Tourists' information search: the differential impact of risk and uncertainty avoidance
Authors: Quintal Vanessa Ann , Lee Julie Anne , Soutar Geoffrey N. 
Published: October 2009

AbstractWhile studies in and out of tourism contexts have explored risk and/or uncertainty avoidance's impact on information search, few have clarified whether the two constructs impact differentially on information search. To examine this issue, data were collected from large online panels in Australia, China and Japan. The risk and uncertainty avoidance scales were reliable, had convergent and discriminant validity and were invariant across the three country samples. As expected, uncertainty avoidance was positively related to the extent of information search in all three country samples, whereas risk avoidance was not. This suggests that the constructs are distinct and may impact at different stages of decision‐making. Copyright © 2009 John Wiley & Sons, Ltd.
Chronic vocal fold scar restoration with hepatocyte growth factor hydrogel
Authors: Kishimoto Yo , Hirano Shigeru , Kitani Yoshiharu , Suehiro Atsushi , Umeda Hiroo , Tateya Ichiro , Kanemaru Shin‐ichi , Tabata Yasuhiko , Ito Juichi 
Published: October 2009

AbstractObjectives/Hypothesis:Therapeutic challenges exist in the management of vocal fold scarring. We have previously demonstrated the therapeutic potential of hepatocyte growth factor (HGF) in the management of acute phase vocal fold scarring using a novel hydrogel‐based HGF drug delivery system (DDS). However, the effect of HGF on matured vocal fold scarring remains unclear. The current study aims to investigate the effect of HGF‐DDS on chronic vocal fold scarring using a canine model.Study Design:Animal model.Methods:Vocal folds from eight beagles were unilaterally scarred by stripping the entire layer of the lamina propria; contralateral vocal folds were kept intact as normal controls. Six months after the procedures, hydrogels (0.5 mL) containing 1 μg of HGF were injected into the scarred vocal folds of four dogs (HGF‐treated group). Hydrogels containing saline solution were injected into the other four dogs (sham group). Histological and vibratory examinations on excised larynges were completed for each group 9 months after the initial surgery.Results:Experiments conducted on excised larynges demonstrated significantly better vibrations in the HGF‐treated group in terms of mucosal wave amplitude. Although phonation threshold pressure was significantly lower in the HGF‐treated group compared with the sham group, no significant differences were observed in the normalized glottal gap between HGF‐treated and sham groups. Histological examinations of the HGF‐treated vocal folds showed reduced collagen deposition and less tissue contraction with favorable restoration of hyaluronic acid.Conclusions:Results suggest that administration of HGF may have therapeutic potential in the treatment of chronic vocal fold scarring. Laryngoscope, 2010
Trends in the management of vestibular schwannomas at Johns Hopkins 1997–2007
Authors: Tan Marietta , Myrie Oluwaseun A. , Lin Frank R. , Niparko John K. , Minor Lloyd B. , Tamargo Rafael J. , Francis Howard W. 
Published: October 2009

AbstractObjectives/Hypothesis:To assess trends in the management of unilateral vestibular schwannomas over an 11‐year period and to identify disease‐ and provider‐related influences.Study Design:Retrospective chart review.Methods:Subjects presented to the Department of Otolaryngology–Head and Neck Surgery and the Department of Neurosurgery for management of unilateral vestibular schwannoma from 1997 through 2007, with at least two visits within the first year of presentation. The proportion of patients for whom initial management consisted of observation, surgical resection, or radiation therapy was determined, and the relative influence of study year, patient age, hearing status, and tumor size was analyzed.Results:Over the study period there was an increase in the proportion of cases that were observed with follow‐up scanning (10.5% to 28.0%) and recommended for radiation (0% to 4.0%), whereas the proportion of operated cases declined (89.5% to 68.0%). There were no changes in mean age or hearing status at diagnosis, but mean tumor size declined significantly. Compared to those undergoing surgery, patients choosing observation and radiation therapy were on average 11.7 and 4.5 years older, respectively. Tumors that were surgically removed were on average 11.6 mm larger than those that were observed. The increasing frequency over time of observation relative to surgery was significant even after controlling for age, hearing status, and tumor size.Conclusions:Among patients managed by our center, there has been a significant shift in management of vestibular schwannomas over the last decade, with increasing tendency towards observation. This trend implies changing provider philosophy and patient expectations. Laryngoscope, 2010
Criteria for farthest points on convex surfaces
Authors: Itoh Jin‐ichi , Vǐlcu Costin 
Published: October 2009

AbstractWe provide a sharp, sufficient condition to decide if a pointyon a convex surfaceSis a farthest point (i.e., is at maximal intrinsic distance from some point) onS, involving a lower boundπon the total curvatureωyaty,ωy≥π. Further consequences are obtained whenωy>π, and sufficient conditions are derived to guarantee that a convex cap contains at least one farthest point. A connection between simple closed quasigeodesicsOofS, pointsy∈S\Owithωy>π, and the set 𝔽 of all farthest points onS, is also investigated (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Structural theorems for quasiasymptotics of distributions at the origin
Authors: Vindas Jasson , Pilipović S. 
Published: October 2009

AbstractAn open question concerning the quasiasymptotic behavior of distributions at the origin is solved. The question is the following: Suppose that a tempered distribution has quasiasymptotic at the origin in S ′(ℝ), then the tempered distribution has quasiasymptotic in D ′(ℝ), does the converse implication hold? The second purpose of this article is to give complete structural theorems for quasiasymptotics at the origin. For this purpose, asymptotically homogeneous functions with respect to slowly varying functions are introduced and analyzed (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
New oxidized sterols from Aspergillus awamori and the endo‐boat conformation adopted by the cyclohexene oxide system
Authors: Gao Hao , Hong Kui , Chen Guo‐Dong , Wang Chuan‐Xi , Tang Jin‐Shan , Yu Yang , Jiang Miao‐Miao , Li Man‐Mei , Wang Nai‐Li , Yao Xin‐Sheng 
Published: October 2009

AbstractTwo new oxidized sterols 1 and 2 were obtained from the active fraction of a mangrove fungus Aspergillus awamori isolated from the soils around the mangrove plant Acrostichum speciosum. Their structures were elucidated using spectroscopic methods as 22E‐7α‐methoxy‐5α,6α‐epoxyergosta‐8(14),22‐dien‐3β‐ol (1) and 22E‐3β‐hydroxy‐5α,6α,8α,14α‐diepoxyergosta‐22‐en‐7‐one (2). The NMR data and complete assignments for both DMSO‐d6 and CDCl3 were given. Their cytotoxic activity against A549 cell line was evaluated. Furthermore, the detailed conformation analysis for ring B (cyclohexene oxide system) of sterol 1 was given on the basis of NOEs. The endo‐boat conformation was considered as the preferred conformation for ring B rather than half‐chair conformation. Copyright © 2009 John Wiley & Sons, Ltd.
Clinical and electrophysiological parameters distinguishing acute‐onset chronic inflammatory demyelinating polyneuropathy from acute inflammatory demyelinating polyneuropathy
Authors: Dionne Annie , Nicolle Michael W. , Hahn Angelika F. 
Published: October 2009

AbstractUp to 16% of chronic inflammatory demyelinating polyneuropathy (CIDP) patients may present acutely. We performed a retrospective chart review on 30 acute inflammatory demyelinating polyneuropathy (AIDP) and 15 acute‐onset CIDP (A‐CIDP) patients looking for any clinical or electrophysiological parameters that might differentiate AIDP from acutely presenting CIDP. A‐CIDP patients were significantly more likely to have prominent sensory signs. They were significantly less likely to have autonomic nervous system involvement, facial weakness, a preceding infectious illness, or need for mechanical ventilation. With regard to electrophysiological features, neither sural‐sparing pattern, sensory ratio >1, nor the presence of A‐waves was different between the two groups. This study suggests that patients presenting acutely with a demyelinating polyneuropathy and the aforementioned clinical features should be closely monitored as they may be more likely to have CIDP at follow‐up. Muscle Nerve, 2010
Coactivation at the ankle joint is not sufficient to estimate agonist and antagonist mechanical contribution
Authors: Billot Maxime , Simoneau Emilie , Van Hoecke Jacques , Martin Alain 
Published: October 2009

AbstractThe aim of this study was to assess, via an electromyographic (EMG) biofeedback method, the mechanical contribution of both agonist and antagonist muscles during maximal voluntary contraction (MVC). We compared this original method with the MVC–EMGmax ratio and the torque/EMG relationship method, both of which are commonly used to estimate antagonist torque. The plantarflexion (PF) and dorsiflexion (DF) MVCs were measured simultaneously with EMG activity of triceps surae (TS) and tibialis anterior in 15 young adults (mean age 23 years). Antagonist torques obtained from the torque/EMG relationship and EMG biofeedback methods appeared to be similar. TS antagonist torque had a major mechanical impact on DF MVC (∼42%). EMG coactivation is significantly different than normalized antagonist torque. TS antagonist torque is not negligible when maximal DF is assessed, and the EMG biofeedback method is a simple method to estimate antagonist torque. Muscle Nerve, 2010
Numerical simulation of the modified regularized long wave equation by He's variational iteration method
Authors: Labidi Manel , Omrani Khaled 
Published: October 2009

AbstractThe modified regularized long wave (MRLW) equation, with some initial conditions, is solved numerically by variational iteration method. This method is useful for obtaining numerical solutions with high degree of accuracy. The variational iteration solution for the MRLW equation converges to its exact solution. Moreover, the conservation laws properties of the MRLW equation are also studied. Finally, interaction of two and three solitary waves is shown. © 2009 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq, 2011
Childhood scurvy in a medieval burial from Mačvanska Mitrovica, Serbia
Authors: Brown Matthew , Ortner Donald J. 
Published: October 2009

AbstractThe type and distribution of abnormalities in the skeleton of a child 2 years of age indicates that the child likely suffered from scurvy at the time of death. The burial is from the archaeological site of Zidine, Mačvanska Mitrovica, Serbia dated to the Medieval Period. Abnormal porosity and reactive woven bone formation are present affecting both the axial and appendicular skeleton. This case of scurvy is important because archaeological evidence of scurvy in this geographical location and at this time period is unknown. It is also important because the relative completeness of the skeleton and the widespread evidence of skeletal abnormalities provide additional insight regarding the skeletal manifestations of scurvy in young children. Copyright © 2009 John Wiley & Sons, Ltd.
Site‐specific inhibition of integrin αvβ3‐vitronectin association by a ser‐asp‐val sequence through an Arg‐Gly‐Asp‐binding site of the integrin
Authors: Choi Youngjin , Kim Eungyoon , Lee Yoonsuk , Han Moon Hi , Kang In‐Cheol 
Published: October 2009

AbstractA functional proteomic technology using protein chip and molecular simulation was used to demonstrate a novel biomolecular interaction between P11, a peptide containing the Ser‐Asp‐Val (SDV) sequence and integrin αvβ3. P11 (HSDVHK) is a novel antagonistic peptide of integrin αvβ3 screened from hexapeptide library through protein chip system. An in silico docking study and competitive protein chip assay revealed that the SDV sequence of P11 is able to create a stable inhibitory complex onto the vitronectin‐binding site of integrin αvβ3. The Arg‐Gly‐Asp (RGD)‐binding site recognition by P11 was site specific because the P11 was inactive for the complex formation of a denatured form of integrin–vitronectin. P11 showed a strong antagonism against αvβ3‐GRGDSP interaction with an IC50 value of 25.72±3.34 nM, whereas the value of GRGDSP peptide was 1968.73±444.32 nM. The binding‐free energies calculated from the docking simulations for each P11 and RGD peptide were −3.99 and −3.10 kcal/mol, respectively. The free energy difference between P11 and RGD corresponds to approximately a 4.5‐fold lower Ki value for the P11 than the RGD peptide. The binding orientation of the docked P11 was similar to the crystal structure of the RGD in αvβ3. The analyzed docked poses suggest that a divalent metal–ion coordination was a common driving force for the formation of both SDV/αvβ3 and RGD/αvβ3 complexes. This is the first report on the specific recognition of the RGD‐binding site of αvβ3 by a non‐RGD containing peptide using a computer‐assisted proteomic approach.
Native immunoblotting of blue native gels to identify conformation‐specific antibodies
Authors: Zickermann Volker , Wumaier Zibiernisha , Wrzesniewska Blanka , Hunte Carola , Schägger Hermann 
Published: October 2009

AbstractA large repertoire of immunological methods permits monitoring the interaction of antibodies with their specific antigen. However, recognition of a protein by a conformation‐specific antibody represents a challenge because native conditions must be kept throughout the assay. Native immunoblotting of blue native gels conserves the native state by using Tween 20 instead of methanol for the obligatory destaining of the blot membrane. We validate the new technique with a set of monoclonal antibodies against respiratory NADH:ubiquinone oxidoreductase.
Elastic and frictional properties of graphene
Authors: Lee Changgu , Wei Xiaoding , Li Qunyang , Carpick Robert , Kysar Jeffrey W. , Hone James 
Published: October 2009

AbstractWe describe studies of the elastic properties and frictional characteristics of graphene samples of varying thickness using an atomic force microscope. For tensile testing, graphene is suspended over micron‐sized circular holes and indented by atomic force microscope (AFM) tips. Fitting of the force‐displacement curves yields the prestress and elastic stiffness, while comparison of the breaking force to simulation gives the ultimate strength, which is the highest measured for any material. Experiments on samples with 1–3 atomic layers yield similar values for the intrinsic stiffness and strength of a single sheet, but also reveal differences in mechanical behavior with thickness. The frictional force between an AFM tip and graphene decreases with thickness for samples from 1 to 4 layers, and does not depend on the presence of a substrate. High‐resolution friction force imaging in stick‐slip mode shows the same trend, and allows direct imaging of the crystal lattice.
Molecular dynamics simulations of picotube peapods
Authors: Rosenkranz Nils , Thomsen Christian 
Published: October 2009

AbstractCarbon picotubes are a promising starting point for the specific synthesis of nanotubes. In this context the interaction between nanotubes and picotubes is of particular interest. One potentially useful configuration evolves from inserting picotubes into a nanotube in a row in analogy to fullerene peapods. We perform temperature‐dependent molecular dynamics simulations on such a system consisting of three tetramer picotubes arranged along the axis of a (9,9) nanotube. Covering a temperature range from room temperature up to 3000 K we observe two different effects: First, our studies show oscillations of the tetramer molecules inside the nanotube. These eigenmodes include axial motion of the picotubes as well as various rotational patterns. Moreover, at sufficiently high temperatures breaking and formation of new bonds results in a structural reorganization, which under suitable conditions might yield a second, inner nanotube of defined chirality.
Anti‐windup synthesis for nonlinear dynamic inversion control schemes
Authors: Herrmann G. , Menon P. P. , Turner M. C. , Bates D. G. , Postlethwaite I. 
Published: October 2009

AbstractA general anti‐windup (AW) compensation scheme is provided for a class of input constrained feedback‐linearizable nonlinear systems. The controller considered is an inner‐loop nonlinear dynamic inversion controller, augmented with an outer‐loop linear controller, of arbitrary structure. For open‐loop globally exponentially stable plants, it is shown that (i) there always exists a globally stabilizing AW compensator corresponding to a nonlinear generalization of the Internal‐Model‐Control (IMC) AW solution; (ii) important operator theoretic parallels exist between the AW design scheme for linear control and the suggested AW design scheme for nonlinear affine plants and (iii) a more attractive AW compensator may be obtained by using a nonlinear state‐feedback term, which plays a role similar to the linear state‐feedback term in linear coprime factor‐based AW compensation. The results are demonstrated on a dual‐tank simulation example. Copyright © 2009 John Wiley & Sons, Ltd.