bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic surgery for endometrial cancer: a phenomenological study
Authors: Hughes Cathy , Knibb Wendy , Allan Helen 
Published: September 2010

hughes c., knibb w. & allan h. (2010) Laparoscopic surgery for endometrial cancer: a phenomenological study. Journal of Advanced Nursing 66(11), 2500–2509.AbstractAim.  This paper is a report of a study of women’s perspectives on the experience of laparoscopic surgery for endometrial cancer.Background.  Laparoscopic surgery is increasingly used to treat early endometrial cancer. It is associated with low levels of morbidity and is considered safe as cancer surgery, but research on quality of life and women’s experiences is limited.Method.  Heideggerian hermeneutic phenomenology was used to explore the experiences of 14 women who had undergone the procedure in two English cancer centres between February 2008 and July 2009. In‐depth interviews were taped, transcribed and analysed using Colaizzi’s framework.Findings.  A phenomenological description was produced from five identified themes: having cancer, transfer of responsibility to the surgeon, information and support, independence, and normality. The experience of laparoscopic surgery was overshadowed by the presence of cancer. Fear and lack of knowledge played an important role in entrusting the surgeon with the responsibility for decision‐making. Individual, unmet information needs focused on the practicalities of treatment and being in an unfamiliar situation and environment. Loss of control and vulnerability were associated with illness and surgery, but early postoperative mobility and reduced pain, facilitated rapid return to independence and maintained a sense of normality.Conclusion.  Healthcare professionals should deliver care in early endometrial cancer in a way that recognizes the significance of the cancer diagnosis, the role of the surgeon in decision‐making and the need for practical information. Women with endometrial cancer should have access to treatments that reduce dependency and maintain normality.
Center for Epidemiologic Studies Depression Scale for Children: psychometric testing of the Chinese version
Authors: William Li Ho Cheung , Chung Oi Kwan Joyce , Ho Ka Yan 
Published: September 2010

li h.c.w., chung o.k.j. & ho k.y. (2010) Center for Epidemiologic Studies Depression Scale for Children: psychometric testing of the Chinese version. Journal of Advanced Nursing 66(11), 2582–2591.AbstractAim.  This paper is a report of psychometric testing of the Chinese version of the Center for Epidemiologic Studies Depression Scale for Children.Background.  The availability of a valid and reliable instrument that accurately detects depressive symptoms in children is crucial before any psychological intervention can be appropriately planned and evaluated. There is no such an instrument for Chinese children.Methods.  A test–retest, within‐subjects design was used. A total of 313 primary school students between the ages of 8 and 12 years were invited to participate in the study in 2009. Participants were asked to respond to the Chinese version of the Center for Epidemiologic Studies Depression Scale for Children, short form of the State Anxiety Scale for Children and Rosenberg’s Self‐Esteem Scale. The internal consistency, content validity and construct validity and test–retest reliability of the Chinese version of the Center for Epidemiologic Studies Depression Scale for Children were assessed.Results.  The newly‐translated scale demonstrated adequate internal consistency, good content validity and appropriate convergent and discriminant validity. Confirmatory factor analysis added further evidence of the construct validity of the scale.Conclusion.  Results suggest that the newly‐translated scale can be used as a self‐report assessment tool in detecting depressive symptoms of Chinese children aged between 8 and 12 years.
Reduced small‐intestinal injury induced by indomethacin in interleukin‐17A‐deficient mice
Authors: Yamada Shinya , Naito Yuji , Takagi Tomohisa , Mizushima Katsura , Hirai Yasuko , Horie Ryusuke , Fukumoto Kohei , Inoue Ken , Harusato Akihito , Yoshida Naohisa , Uchiyama Kazuhiko , Handa Osamu , Ishikawa Takeshi , Konishi Hideyuki , Wakabayashi Naoki , Yagi Nobuaki , Kokura Satoshi , Kita Masakazu , Yoshikawa Toshikazu 
Published: September 2010

AbstractBackground and Aims:  The pathogenesis of enteropathy induced by non‐steroidal anti‐inflammatory drugs (NSAIDs) is still unclear, and there are no established treatments. Interleukin‐17A (IL‐17A) is a pro‐inflammatory cytokine that has been associated with the development of chronic inflammatory diseases, including autoimmune diseases. To define the role of IL‐17A in small intestinal injury and inflammation, we studied the effects of indomethacin administration in mice with targeted deletions of the IL‐17A gene.Methods:  Male C57BL/6 (wild‐type) and homozygous IL‐17A‐/‐ C57BL/6 mice were subjected to this study. Indomethacin (10 mg/kg) was subcutaneously administered to induce small‐intestinal damage. Indomethacin‐induced lesions in the small intestine were evaluated by measuring the injured area and by histopathology. Also assessed were myeloperoxidase (MPO) activity, as an index of neutrophil accumulation, and intestinal mRNA expression for inflammatory cytokines.Results:  The area of macroscopic ulcerative lesions, the MPO activity and the mRNA expression of inflammatory‐associated chemokines, such as keratinocyte chemoattractant (KC), monocyte chemotactic protein‐1 (MCP‐1), and granulocyte‐colony stimulating factor (G‐CSF), were significantly increased in indomethacin‐treated groups compared with the sham groups. The development of intestinal lesions by indomethacin was inhibited in IL‐17A‐/‐ mice compared with wild‐type mice, together with significant suppression of the increased levels of MPO activities and KC, MCP‐1, and G‐CSF levels.Conclusion:  These findings demonstrate that IL‐17A contributes to the development of indomethacin‐induced small intestinal injury through upregulation of G‐CSF, KC, and MCP‐1. IL‐17A might be a promising new therapeutic target to treat NSAID‐induced enteritis.
Effect of Lactobacillus plantarum LP‐Onlly on gut flora and colitis in interleukin‐10 knockout mice
Authors: Xia Yang , Chen Hong‐Qi , Zhang Min , Jiang Yan‐Qun , Hang Xiao‐Min , Qin Huan‐Long 
Published: September 2010

AbstractBackground and Aim:  Probiotics are used in the therapy of inflammatory bowel disease. This study aimed to determine the effects of probiotic Lactobacillus plantarum LP‐Onlly (LP) on gut flora and colitis in interleukin‐10 knockout (IL‐10−/−) mice, a model of spontaneous colitis.Methods:  IL‐10−/− and wild‐type mice were used at 8 weeks of age and LP by gavage was administered at a dose of 109 cells/day per mice for 4 weeks. Mice were maintained for another one week without LP treatment. The colonic tissues were collected for histological and ultrastructural analysis at death after 4 weeks treatment of LP, and the feces were collected at 1‐week intervals throughout the experiment for the analysis of gut flora and LP using selective culture‐based techniques.Results:  Compared with control mice, IL‐10−/− mice developed a severe intestinal inflammation and tissue damage, and had an abnormal composition of gut microflora. LP administration attenuated colitis with the decreased inflammatory scoring and histological injury in the colon of IL‐10−/− mice. In addition, LP administration increased the numbers of beneficial total bifidobacteria and lactobacilli, and decreased the numbers of potential pathogenic enterococci and Clostridium perfringens, although the decrease of coliforms was not significant after LP treatment in IL‐10−/− mice.Conclusions:  Oral administration of LP was effective in the treatment of colitis, with the direct modification of gut microflora in IL‐10−/− mice. This probiotic strain could be used as a potential adjuvant in the therapy of inflammatory bowel disease, although further studies are required in human.
Urinary matrix metalloproteinase‐7 level is associated with the presence of metastasis in bladder cancer
Authors: Szarvas Tibor , Singer Bernhard B. , Becker Markus , vom Dorp Frank , Jäger Tobias , Szendrői Attila , Riesz Péter , Romics Imre , Rübben Herbert , Ergün Süleyman 
Published: September 2010

Study Type – Therapy (case series) Level of Evidence 4 What’s known on the subject? and What does the study add? Recent data suggest that MMP‐7 is critically involved in metastasis formation. In accordance, we formerly found significantly elevated MMP‐7 tissue expression and serum concentration in samples of patients with metastatic bladder cancer and observed an independent correlation between MMP‐7 levels and patients’ prognosis. In the present study we demonstrated that high preoperative urinary MMP‐7 concentrations are associated with metastatic bladder cancer.OBJECTIVE• To assess the presence of matrix metalloproteinase (MMP)‐7 in urine samples of patients with bladder cancer and to investigate the correlation between MMP‐7 urine concentration and clinicopathological variables.PATIENTS AND METHODS• The presence of MMP‐7 in the urine of patients with bladder cancer was tested in 32 representative cases using immunoprecipitation followed by western blot analysis.• Urinary MMP‐7 concentration levels were analyzed in 132 patients with bladder cancer and 96 controls using an enzyme‐linked immunosorbent assay.RESULTS• MMP‐7 levels did not differ significantly between patients with localized bladder cancer and controls (P= 0.174). On the other hand, we detected a fourfold, significantly elevated MMP‐7 concentration in urine samples of patients with bladder cancer with regional or distant metastasis (P= 0.003).• Using a threshold value of 6.88 ng/ml, determined by receiver‐operating characteristic curve analysis, a specificity of 82% and a sensitivity of 78% were observed.• Western blot analysis revealed that the 55‐kDa tissue inhibitor of metalloproteinase 1 complexed MMP‐7 is the dominant form of urinary matrilysin.CONCLUSIONS• MMP‐7 is present in detectable amounts in the urine of patients with bladder cancer. Its concentrations are significantly elevated in patients with metastatic disease.• Determination of urinary matrilysin level could help to detect bladder cancer metastasis, and may therefore provide a more reliable prognosis and influence therapy decisions.
Acculturation among immigrant nurses in Israel and the United States of America
Authors: Ea E. , Itzhaki M. , Ehrenfeld M. , Fitzpatrick J. 
Published: September 2010

EA E., ITZHAKI M., EHRENFELD M. & FITZPATRICK J. (2010) Acculturation among immigrant nurses in Israel and the United States of America. International Nursing ReviewBackground:  Former Soviet Union (FSU) nurses in Israel and Filipino registered nurses (RNs) in the United States of America (USA) play significant roles in the delivery of health‐care services in their host countries. However, little is known about how they acculturate in a different culture.Objectives:  The purposes of this study were to determine the levels of and the difference in acculturation of FSU nurses in Israel and Filipino RNs in the USA.Methods:  Acculturation was assessed using A Short Acculturation Scale for Filipino Americans and t‐test was conducted to determine the difference in acculturation between these two groups of immigrant nurses.Findings:  Results revealed that Filipino RNs have an acculturation level that leaned towards their host culture while FSU nurses have an acculturation level that was closer to their original culture than the Israeli culture and that there was a significant difference in acculturation between these two groups of immigrant nurses.Conclusions:  Differences in acculturation between two predominant groups of immigrant nurses in Israel and the USA exist. Understanding the differences and the factors that affect their integration into their host cultures could be used to develop strategies to assist Filipino and FSU immigrant nurses achieve positive personal and work‐related outcomes.
The transcultural nursing concept: a study of nursing students in Turkey
Authors: Ayaz S. , Bilgili N. , Akın B. 
Published: September 2010

AYAZ S., BILGILI N. & AKIN B. (2010) The transcultural nursing concept: a study of nursing students in Turkey. International Nursing ReviewBackground:  Cultural differences are known to be pronounced in Turkey, and some difficulties are encountered in patient care. Cultural sufficiency in providing health care to the patients is of great importance in satisfactory care delivery.Aim:  To determine the cultural diversity that the students experienced between the patients and themselves while providing care to patients. Knowledge of transcultural nursing was also investigated.Design and Methods:  This was a descriptive study. The population comprised of 650 undergraduate students attending the nursing schools of three universities. A total of 622 students were included in the sample. The survey method was used for data collection. Percentages and chi‐square test were used.Results:  Most of the students (85.5%) had experienced cultural differences while giving care to their patients and 73.8% did not know the definition of this concept. The issues where cultural differences were experienced to the highest degree were differences in dialect and pronunciation (53.4%), differences of language (37%), traditions and customs of the individual (30.7%), and religious belief and sect (30.2%). It was found that the grade the students were in had a significant effect on the experience of cultural differences (P < 0.05).Conclusions:  The majority of students experience cultural diversity in patient care. It is thought that transcultural care placed in curriculum even as a separate course will guide nursing students in all stages of patient care. Thus, the effect of cultural diversity in patient care can be minimized with the help of education.
Weight gain following treatment with valproic acid: pathogenetic mechanisms and clinical implications
Authors: Verrotti A. , D'Egidio C. , Mohn A. , Coppola G. , Chiarelli F. 
Published: September 2010

SummaryIn the last years, a growing body of literature indicates an association between valproic acid therapy and weight gain. Weight gain during valproate treatment can be observed within the first 3 months of therapy and women seem to be more susceptible than men. The mechanism through which valproic acid may induce a weight gain is still controversial. The scope of this paper is to investigate the possible causal link between treatment and weight gain in epileptic patients. Systematic review of published epidemiological studies has been done in order to evaluate the real extent of this side effect of valproic acid and its clinical implications, such as an increased risk of insulin resistance and other secondary metabolic abnormalities. The knowledge of the potential of valproic acid to cause significant changes in body weight will help in appropriate selection and modification of antiepileptic therapy to minimize the risk for weight abnormalities. Measurements of body weight before initiation of valproic acid therapy should be done as part of the monitoring of patients with epilepsy to detect changes before there are serious adverse consequences; an increase of 2 kg of body weight after 1 month of treatment should imply considerations to change antiepileptic drug therapy.
Permanently Provisional: History, Facts & Figures of Portuguese Immigration in Switzerland
Authors: Afonso Alexandre 
Published: September 2010

AbstractThis article provides an overview of the main demographic, social, and economic characteristics of Portuguese immigration in Switzerland. Firstly, it outlines the political and economic underpinnings of Portuguese migration flows to Switzerland. Then, it analyzes the demographic and sociological composition of these flows, the composition of the Portuguese population in Switzerland, as well as processes of economic and cultural integration. It is notably argued that the enduring Portuguese “ideology of return migration” has played a central role in the patterns of integration of Portuguese immigrants in Switzerland.
The metabolic theory of ecology: prospects and challenges for plant biology
Authors: Price Charles A. , Gilooly James F. , Allen Andrew P. , Weitz Joshua S. , Niklas Karl J. 
Published: September 2010

SummaryThe metabolic theory of ecology (MTE) as applied to the plant sciences aims to provide a general synthesis for the structure and functioning of plants from organelles to ecosystems. MTE builds from simple assumptions of individual metabolism to make predictions about phenomena across a wide range of scales, from individual plant structure and function to community dynamics and global nutrient cycles. The scope of its predictions include morphological allometry, biomass partitioning, vascular network design, and life history phenomena at the individual level; size‐frequency distributions, population growth rates, and energetic equivalence at the community level; and the flux, turnover and storage of nutrients at the ecosystem level. Here, we provide an overview of MTE, by considering its assumptions and predictions at these different levels of organization and explaining how the model integrates phenomena among all of these scales. We highlight the model’s many successes in predicting novel patterns and draw attention to areas in which gaps remain between observations and MTE’s assumptions and predictions. Considering the theory as a whole, we argue that MTE has made a significant contribution in furthering our understanding of those unifying aspects of the structure and function of plants, populations, communities, and ecosystems.ContentsSummary696I.Introduction697II.Background and theoretical foundations: assumptions of WBE698III.Background and theoretical foundations: assumptions of MTE699IV.MTE at the individual plant level: metabolism, architecture and demography699V.Metabolism700VI.Morphology701VII.Biomass partitioning701VIII.Hydraulics702IX.Demography702X.MTE at population, community, and ecosystem scales703XI.Plant population density703XII.Plant population density within a site704XIII.Population growth rates704XIV.Ecosystem dynamics705XV.Discussion706Acknowledgements708References708
Lizard predation alters the effect of habitat area on the species richness of insect assemblages on Bahamian isles
Authors: Murakami Masashi , Hirao Toshihide 
Published: September 2010

AbstractAim Anolis lizard invasions are a serious threat world‐wide, and information about how this invasive predator affects the diversity of prey assemblages is important for many strategic conservation goals. It is hypothesized that these predators reduce the slope of species–area relationships (SARs) of their prey assemblages. The effects of island area and predation by anolis lizards on the species richness of insular insect assemblages were investigated.Location Twenty‐four isles around Staniel Cay, Exuma Cays, Bahamas.Methods Flying insects were sampled using half‐sized Malaise traps for three consecutive days on each island in May 2007. First, the effect of island area on the probability of lizard presence was evaluated. Then, the effects of the presence–absence of predatory lizards on SARs were analysed for the overall insect assemblage and for the assemblages of five dominant insect orders.Results Our results indicated that anolis lizards occurred primarily on larger islands. The species richness of the overall insect assemblage and five dominant insect orders significantly increased with island area. The interaction between island area and predator presence–absence significantly affected the overall insect assemblage and Diptera and Hymenoptera assemblages (but not Coleoptera, Hemiptera and Lepidoptera assemblages). The presence of predators caused decreases in the slope of the SARs.Main conclusions The presence of predatory lizards strongly affects species richness of insular insect assemblages with the island area being a crucial determinant of the species richness. Therefore, the slope of the SAR can serve as a measure of the consequence of invasive predatory species on native insect assemblages.
Prevention of retinopathy of prematurity in preterm infants through changes in clinical practice and SpO2technology
Authors: Castillo Armando , Deulofeut Richard , Critz Ann , Sola Augusto 
Published: September 2010

AbstractAim: To identify whether pulse oximetry technology is associated with decreased retinopathy of prematurity (ROP) and laser treatment.Methods: Inborn infants <1250 g who had eye exams were compared at two centres in three periods. In Period 1, SpO2target was ≥93% and pulse oximetry technology was the same in both Centres. In Period 2, guidelines for SpO288–93% were implemented at both centres and Centre B changed to oximeters with signal extraction technology (SET®) while Centre A did not, but did so in Period 3. One ophthalmology department performed eye exams using international criteria.Results: In 571 newborns <1250 g, birth weight and gestational age were similar in the different periods and centres. At Centre A, severe ROP and need for laser remained the same in Periods 1 and 2, decreasing in Period 3–6% and 3%, respectively. At Centre B, severe ROP decreased from 12% (Period 1) to 5% (Period 2) and need for laser decreased from 5% to 3%, remaining low in Period 3.Conclusion: In a large group of inborn infants <1250 g, a change in clinical practice in combination with pulse oximetry with Masimo SET, but not without it, led to significant reduction in severe ROP and need for laser therapy. Pulse oximetry selection is important in managing critically ill infants.
A case study and comprehensive differential diagnosis and care plan for the three Ds of women's health: Primary dysmenorrhea, secondary dysmenorrhea, and dyspareunia
Authors: Stoelting‐Gettelfinger Wendy 
Published: September 2010

Abstract  Purpose: To provide a case study for the discussion, diagnosis, management, and comprehensive plan of care for primary dysmenorrhea, secondary dysmenorrhea, and dyspareunia for the advanced practice registered nurse (APRN) working in primary care. Data sources: Selected text, research, clinical articles, and personal communication with expert APRNs. Conclusions: Three of the most commonly presenting women's health related conditions include primary dysmenorrhea, secondary dysmenorrhea, and dyspareunia. These conditions can present a challenge in developing an accurate differential diagnosis and appropriate plan of care. This article presents the reader with a detailed case study that provides an analysis of each potential differential diagnosis with rationale. A recommended diagnostic and therapeutic plan of care is included for the reader's review. Implications for practice: If left untreated, primary dysmenorrhea, secondary dysmenorrhea, and dyspareunia can result in pain, suffering, and impaired fertility and sexual function. Patients frequently experience symptoms for months to years prior to accurate diagnosis.