bluuebunny/crossref_metadata_2025_split huggingface dataset:
Green‐Emissive Carbon Dots with a High Quantum Yield Applied for Photoconversion Film to Prevent from Blue Light Damage
Authors: Li Longchuang , Li Yuan , Zhang Tao , Li Yan , Li Zijian , Bi Hong 
Published: May 2024

AbstractHigh‐energy blue light is highly detrimental to health as it can penetrate the lens into the retina, potentially causing atrophy or even death of retinal pigment epithelial cells. To prevent the harmful effects of high‐energy blue light on our health, here the preparation of a photoconversion film specifically designed to block high‐energy blue light is reported, which is composed of green‐emissive carbon dots (G‐CDs) with a high photoluminescence quantum yield (PLQY = 95%) dispersed in polyvinyl alcohol (PVA) matrix. Notably, such a film (named as G‐CDs@PVA) not only converts an incident laser light with a short wavelength into a fluorescence with a longer wavelength, but also exhibits concentration‐dependent (0, 10, 20, and 30 wt.%) blue light barrier rate and green‐emissive intensity. With the increase of the concentration of G‐CDs in the film, the blue light barrier rate of the film as well as the maximum intensity of the green emission are also increased. When the concentration of G‐CDs reaches 30 wt.%, the blue light barrier rate of G‐CDs@PVA achieves up to 97%. Furthermore, G‐CDs@PVA film is attached to a blue light‐emitting diode (LED) chip to explore its practical application in the field of blocking blue light damage.
Threatened cetaceans off the coast of Israel and long‐range movement of a sperm whale
Authors: Thompson Kirsten F. , Gordon Jonathan , Webber Thomas , Zuriel Yotam , Kobo Kim , Tchernov Dan , Airoldi Sabina , Violi Biagio , Verga Alessandro , Gannier Adrien , Fontanesi Elena , Ascheri Davide , Scheinin Aviad P. 
Published: May 2024

Abstract
Research in the western Mediterranean has shown that sperm (Physeter macrocephalus) and Cuvier's beaked whales (Ziphius cavirostris) are present as small, globally distinct populations that face numerous threats.
The eastern Mediterranean is not well studied, and few surveys have investigated the composition of cetacean communities. In this study, visual‐acoustic surveys were conducted off the coast of Israel during April–May 2022 to characterize the cetacean community.
Sperm whales (three encounters), Cuvier's beaked whales (one encounter), bottlenose dolphins (one encounter (Tursiops truncatus)) and unidentified delphinids (17 encounters) were acoustically detected.
Sperm whales were foraging ~10 km off Haifa, at 370–1220 m deep and social vocalizations (codas) corresponded to the Mediterranean dialect. One immature male that was photographed is known from 12 previous encounters in the Ligurian Sea, indicating a west–east movement of approximately 2800 km.
Automated passive acoustic monitoring of narrow, relatively shallow areas such as the Sicily Channel could provide an opportunity to reduce mortality of individuals making long‐distance movements within Mediterranean basins. Israeli waters provide habitat for cetaceans, with two threatened subpopulations—sperm and Cuvier's beaked whales—that are negatively impacted by anthropogenic activities, including those that introduce underwater noise. More data are needed on densities of these deep‐water species, and an evaluation of the threats faced in the wider Levantine basin.
Synergistic cytotoxicity and in vitro antioxidant activity of hederagenin and its glycoside from quinoa
Authors: Zhang Guangjie , Zhao Hongmei , Li Junfeng , Guan Tianzhu , Zhang Jie 
Published: May 2024

AbstractAlthough a series of studies confirm the bioactivities of hederagenin and its glycosides, their synergistic effects and potential mechanisms are still worthy of further exploration. This work investigated the synergistic cytotoxicity and in vitro antioxidant activity of hederagenin and hederagenin 28‐O‐β‐d‐glucopyranoside (28‐Glc‐hederagenin). Hederagenin and 28‐Glc‐hederagenin inhibited HeLa cell growth and their combination further strengthened this effect. The combination of hederagenin and 28‐Glc‐hederagenin significantly increased the rate of apoptotic cells, suggesting the presence of a synergistic effect between the two substances. This combination also enhanced in vitro antioxidant activity compared with individual treatments. A network pharmacology and molecular docking‐based approach was performed to explore the underlying mechanisms of hederagenin and 28‐Glc‐hederagenin against cervical cancer and oxidant damage. This work identified 18 related Kyoto Encyclopedia of Genes and Genome pathways, 202 related biological process terms, 17 related CC terms, and 35 related molecular function terms and then revealed 30 nodes and 196 edges. Subsequently, two highly connected clusters and the top four targets were identified. Molecular docking showed potent binding affinity of hederagenin and 28‐Glc‐hederagenin toward core targets associated with both cervical cancer and oxidant damage. This work may provide scientific basis for the combined use of hederagenin and its glycosides as dietary supplements.
Introducing AnatomyGPT: A customized artificial intelligence application for anatomical sciences education
Authors: Collins Bradley R. , Black Erik W. , Rarey Kyle E. 
Published: May 2024

AbstractArtificial intelligence (AI) technologies are poised to become an increasingly important part of education in the anatomical sciences. OpenAI has also introduced generative pretrained transformers (GPTs), which are customizable versions of the standard ChatGPT application. There is little research that has explored the potential of GPTs to serve as intelligent tutoring systems for learning the anatomical sciences. The objective of this study was to describe the design and explore the performance of AnatomyGPT, a customized artificial intelligence application intended for anatomical sciences education. The AnatomyGPT application was configured with GPT Builder by uploading open‐source textbooks as knowledge sources and by providing pedagogical instructions for how to interact with users. The performance of AnatomyGPT was compared with ChatGPT by evaluating the responses of both applications to prompts of the National Board of Medical Examiners (NBME) sample items with respect to accuracy, rationales, and citations. AnatomyGPT achieved high scores on the NBME sample items for Gross Anatomy, Embryology, Histology, and Neuroscience and scored comparably to ChatGPT. In addition, AnatomyGPT provided several citations in the responses that it generated, while ChatGPT provided none. Both GPTs provided rationales for all sample items. The customized AnatomyGPT application demonstrated preliminary potential as an intelligent tutoring system by generating responses with increased citations as compared with the standard ChatGPT application. The findings of this study suggest that instructors and students may wish to create their own custom GPTs for teaching and learning anatomy. Future research is needed to further develop and characterize the potential of GPTs for anatomy education.
When the therapist's and the client's woundedness meet: Dialogical selves of Filipino self‐identified wounded healers
Authors: Topacio Anne Marie D. , Ofreneo Mira Alexis P. 
Published: May 2024

AbstractIntroductionThe dominant literature on wounded healers assumes that the healer must be healed of one's wounds to be an effective therapist and that countertransference, moments in therapy when a healer's wounds are activated, must be successfully managed. Lacking in the literature is an understanding of the internal dynamics of wounded healers as they navigate moments of countertransference. Veering away from a unitary and static view of the self, we argue for a shift in how we understand wounded healers using the lens of a multiple and dynamic self. Through Herman's dialogical self‐theory, we conceptualise the wounded healer as having multiple selves—the wounded self (WS) and the therapist self (TS). Each self is an I‐position with its own unique voices and narratives.MethodThrough in‐depth interviews with Filipino self‐identified wounded healers, we examine the internal voices of the WS and TS during moments of countertransference, as the WS meets the client's wounded self.FindingsResults show that the participants' characterisation of their WS, or where they are in their journey of healing or recovery, shapes their countertransference experience. Participants with recovered WS channelled the voices of calm recognition and differentiation. Voices of identification, re‐experiencing and differentiation surfaced among participants with recovering WS. Participants with emerging WS transitioned from a voice of not knowing to a voice of identification.ConclusionBeing aware of and listening to the voices of the WS alongside the TS is key in navigating countertransference. The implications of a dialogical understanding of wounded healers in clinical practice are discussed.
Radiofrequency atrial flutter and atrial fibrillation ablation in a patient with deep brain stimulation
Authors: Nguyen Thomas , Ganse Gildas , Berdaoui Brahim , Verbeet Thierry , Castro‐Rodriguez José 
Published: May 2024

Key Clinical MessageRadiofrequency ablation for atrial fibrillation or atrial flutter is feasible in patients with deep brain stimulation but with extreme caution given the possibility of life‐threatening complications.
A case of SIADH following uncomplicated mild traumatic brain injury: Did cognitive bias delay treatment?
Authors: Rothka Andrew Joseph , Jonik Sarahrose , Nelsen Jacob , Patel Shivani , Cherin Neyha 
Published: May 2024

Key Clinical MessageTo optimize clinical care, it is imperative for providers to recognize their own inherent cognitive biases and the impact that has on their clinical decision making, thereby minimizing complications such as prolonged hospitalization, unnecessary healthcare spending, and impaired patient satisfaction and functional outcomes.
Eculizumab for paroxysmal nocturnal hemoglobinuria: Two cases of successful pregnancy outcomes
Authors: Ilic Jovanka , Pujic Borislava , Jakovljevic Branislava , Sekulic Borivoj , Agic Danijela , El Farra Amir , Micanovic Branimir , Vejnovic Tihomir , Urosevic Ivana , Savic Aleksandar 
Published: May 2024

Key Clinical MessageParoxysmal nocturnal hemoglobinuria is a rare disease with the incidence ranging from 0.08 to 0.57 per 100,000 person‐years. Up to 25% of cases in women are detected during pregnancy. We report two cases of successful pregnancy outcomes in patients treated with eculizumab, pointing out the importance of interdisciplinary approach in these high‐risk pregnancies.
Chemical Design Strategy of Ionizable Lipids for In Vivo mRNA Delivery
Authors: He Zepeng , Liu Zhijia , Chen Yongming 
Published: May 2024

AbstractLipid nanoparticles (LNPs) are the most clinically successful drug delivery systems that have accelerated the development of mRNA drugs and vaccines. Among various structural components of LNPs, more recent attention has been paid in ionizable lipids (ILs) that was supposed as the key component in determining the effectiveness of LNPs for in vivo mRNA delivery. ILs are typically comprised of three moieties including ionizable heads, linkers, and hydrophobic tails, which suggested that the combination of different functional groups in three moieties could produce ILs with diverse chemical structures and biological identities. In this concept article, we provide a summary of chemical design strategy for high‐performing IL candidates and discuss their structure‐activity relationships for shifting tissue‐selective mRNA delivery. We also propose an outlook for the development of next‐generation ILs, enabling the broader translation of mRNA formulated with LNPs.
A 3X and X/3 voltage conversion‐based bidirectional CuK converter for supercapacitor‐assisted electric vehicles
Authors: Kumar Singh Ankit , Kumar Mishra Anjanee 
Published: May 2024

AbstractIn this paper, a high‐gain bidirectional DC–DC converter is presented for electric vehicles where low terminal voltage source like a supercapacitor is used along with the battery. The supercapacitor provides or absorbs large amount power during acceleration and deacceleration and extends the life of main energy source, that is, battery. The supercapacitor terminal voltage varies considerably during charging and discharging activities; hence, a bidirectional DC–DC converter with a high‐voltage conversion ratio must be used to connect the lower supercapacitor voltage to the higher DC‐link voltage. Such application requires steep voltage conversion ratio along with continuous gain‐based bidirectional DC–DC converters. In this study, a typical CuK converter is employed to produce a voltage gain of 3X and X/3 with the ability to transmit power in both directions. The suggested bidirectional converter has a continuous current on both the low‐ and high‐voltage sides, which reduces the requirement for filter capacitance and increases the lifespan of the supercapacitor and DC‐link capacitor. Further, inherent inrush current safety is provided by the proposed converter as the inclusion of an inductor in the path of capacitor charging or discharging. Both in the charging and discharging phases, a detailed steady‐state analysis of the proposed circuit was performed. Moreover, a deep discharge analysis of the supercapacitor and its implication on the performance of the converter is also investigated.
Barriers to curriculum accessibility for students with visual impairment in general education setting: The experience of lower secondary school students in Senegal
Authors: Diasse Mbaye Dieng , Kawai Norimune 
Published: May 2024

AbstractThis study explores potential barriers to curriculum accessibility for lower‐secondary school students with visual impairment in Senegal. A qualitative case study approach was used with purposeful sampling to collect data at a special school for students with visual impairment, and the three junior high schools that offer placement to the students with visual impairment after primary graduation from the special school. The study comprised 22 participants including six students with visual impairment, six regular teachers, three paraeducators, three special education teachers, and the four administrators of the schools. Data were collected using semi‐structured interviews, focus group discussions, and classroom observations. The study concluded that students with visual impairment in lower secondary schools face several obstacles to having proper access to the general education curriculum. The results highlight a lack of training and skills for teachers having students with visual impairment in junior high schools, a shortage of curriculum materials and adaptations, inconvenience of classroom environment, and a restricted collaboration between actors.
Exploratory investigation of virtual lesions in gastrointestinal endoscopy using a novel phase‐shift method for three‐dimensional shape measurement
Authors: Sakamoto Taku , Oda Ichiro , Okamura Takuma , Cho Hourin , Toyoshima Naoya , Nonaka Satoru , Suzuki Haruhisa , Nakamura Tatsuya , Watanabe Daichi , Matsuo Keigo , Hanano Kazunari , Takeyama Tetsuhide , Yoshinaga Shigetaka , Saito Yutaka 
Published: May 2024

AbstractAccurate measurement of the size of lesions or distances between any two points during endoscopic examination of the gastrointestinal tract is difficult owing to the fisheye lens used in endoscopy. To overcome this issue, we developed a phase‐shift method to measure three‐dimensional (3D) data on a curved surface, which we present herein. Our system allows the creation of 3D shapes on a curved surface by the phase‐shift method using a stripe pattern projected from a small projecting device to an object. For evaluation, 88 measurement points were inserted in porcine stomach tissue, attached to a half‐pipe jig, with an inner radius of 21 mm. The accuracy and precision of the measurement data for our shape measurement system were compared with the data obtained using an Olympus STM6 measurement microscope. The accuracy of the path length of a simulated protruded lesion was evaluated using a plaster model of the curved stomach and graph paper. The difference in height measures between the measurement microscope and measurement system data was 0.24 mm for the 88 measurement points on the curved surface of the porcine stomach. The error in the path length measurement for a lesion on an underlying curved surface was <1% for a 10‐mm lesion. The software was developed for the automated calculation of the major and minor diameters of each lesion. The accuracy of our measurement system could improve the accuracy of determining the size of lesions, whether protruded or depressed, regardless of the curvature of the underlying surface.
The effect of drought‐induced leaf traits onFicusleaf palatability is species specific
Authors: Xiao Xue , Jorge Leonardo Ré , Volf Martin , Moos Martin , Gélin Uriel , Finnie Sam , Freiberga Inga , Jancuchova‐Laskova Jitka , Weiss Matthias , Novotny Vojtech , Sam Katerina 
Published: May 2024

AbstractDrought has a significant impact on plant–insect interactions by altering plant survival, growth, leaf quality, and defense traits. Tropical plants are particularly vulnerable to water depression because of shallow root depth. In the context of climate change, drought events are expected to increase in frequency and intensity; however, their impact on tropical ecosystems remains poorly known. Insect herbivores represent the largest feeding guild of arthropods, and they devour four to five times more plant material than vertebrates do. Understanding how drought affects plant traits and leaf palatability in a keystone and ecologically diverse plant genus, such asFicus(Moraceae), is crucial for predicting how climate change might alter tropical plant–insect interactions. We examined the impact of drought intensity and duration on the leaf nutritional quality, defensive traits, and herbivory damage by caterpillars in three tropical and one MediterraneanFicusspecies in a greenhouse. We also conducted food choice trials with generalist caterpillars to evaluate the impact of drought on herbivores. Drought intensity and duration had no direct effect on leaf palatability across theFicusspecies. However, drought indirectly affected leaf palatability via drought‐induced leaf traits in a species‐specific manner. Drought intensity and duration decreased leaf water content, resulting in decreased leaf palatability inF. benjaminaandF. lyrata. Leaf defensive traits such as flavonoid concentration were affected by drought intensity and decreased leaf palatability inF. carica. Drought influenced the leaf traits ofF. elastica, but none of them affected leaf palatability. Overall, this study establishes the link between drought and insect feeding on plants via leaf traits. The species‐specific responses to drought highlight the significance of climate‐related plant life histories in relation to climate change, underscoring the need for further investigations.
VA‐ECMO weaning strategy using adjusted pulse pressure by vasoactive inotropic score in AMI complicated by cardiogenic shock
Authors: Lee Bo Ram , Choi Ki Hong , Kim Eun Jin , Lee Seung Hun , Park Taek Kyu , Lee Joo Myung , Song Young Bin , Hahn Joo‐Yong , Choi Seung‐Hyuk , Gwon Hyeon‐Cheol , Cho Yang Hyun , Yang Jeong Hoon 
Published: May 2024

AbstractAimsThis study evaluated how well serial pulse pressure (PP) and PP adjusted by the vasoactive inotropic score (VIS) predicted venoarterial extracorporeal membrane oxygenation (VA‐ECMO) weaning success and clinical outcomes in acute myocardial infarction complicated by cardiogenic shock (AMI‐CS) patients.Methods and resultsA total of 213 patients with AMI‐CS who received VA‐ECMO between January 2010 and August 2021 were enrolled in the institutional ECMO registry. Serial PP and VIS were measured immediately, 12, 24, and 48 h after VA‐ECMO insertion. PP adjusted by VIS was defined as PP/√VIS. The primary outcome was successful VA‐ECMO weaning. Successful weaning from VA‐ECMO was observed in 151 patients (70.9%). Immediately after VA‐ECMO insertion, PP [successful vs. failed weaning, 26.0 (15.5–46.0) vs. 21.0 (12.5–33.0), P = 0.386] and PP/√VIS [11.1 (5.1–25.0) vs. 6.0 (3.1–14.2), P = 0.118] did not differ between the successful and failed weaning groups. Serial PP and PP adjusted by VIS at 12, 24, and 48 h after VA‐ECMO insertion were significantly higher in patients with successful weaning than those with failed weaning [successful vs. failed weaning, 24.0 (4.0–38.0) vs. 12.5 (6.0–25.5), P = 0.007 for 12 h PP, and 10.1 (5.7–22.0) vs. 2.9 (1.7–5.9), P < 0.001 for 12 h PP/√VIS]. The 12 h PP/√VIS showed better discriminative function for successful weaning than 12 h PP alone [area under the curve (AUC) 0.80, 95% confidence interval (CI) 0.72–0.88, P < 0.001 vs. AUC 0.67, 95% CI 0.57–0.77, P = 0.002]. Patients with a low 12 h PP/√VIS (≤7) had higher rates of in‐hospital mortality (44.4% vs. 19.8%, P < 0.001) and 6 month follow‐up mortality (hazard ratio 2.41, 95% CI 1.49–3.90, P < 0.001) than those with a high 12 h PP/√VIS (>7).ConclusionsPP adjusted by VIS taken 12 h following VA‐ECMO initiation can predict weaning from VA‐ECMO more successfully than PP alone, and its low value was associated with a higher risk of mortality in AMI‐CS patients.
Optimization of gate structure towards high‐sensitivity AlGaN/GaN HEMT cortisol detection
Authors: Chang Hui , Xu Boxuan , Yang Guo , Gu Zhiqi , Li Jiadong 
Published: May 2024

AbstractAlGaN/GaN high electron mobility transistors (HEMTs) have been widely studied in the field of bio‐sensing due to their advantages such as high sensitivity, excellent biocompatibility, rapid response and corrosion resistance. Previously, attention was focused on the impact of width/length ratio (W/LSD) on transconductance (gm) to improve the sensitivity, however, the position of gate (LGS/LGD) also affects the sensitivity of HEMT sensors towards biosensing. Herein, we optimized the gate geometry based on the fixed gate position at LGS/LGD=3/5. Through theoretical analysis, design, and fabrication, three AlGaN/GaN HEMT devices with W/LSD ratios of 800 μm/200 μm, 800 μm/100 μm, and 800 μm/50 μm were developed, consistently maintaining LGS/LGD at 3/5 and LG/LSD at 1/5. Using cortisol as the biochemical detection target, the sensitivity, specificity, and linearity of three different gate structures of AlGaN/GaN HEMT biosensors were validated. The results indicated that with the increase of W/LSD and the decrease of LG, the sensitivity of the three AlGaN/GaN HEMT devices significantly improved, reaching 0.455 μA dec−1, 0.880 μA dec−1, and 2.316 μA dec−1, respectively. The device with W/LSD=800 μm/50 μm and LG=10 μm showed a sensitivity approximately 5 times that of the device with W/LSD=800 μm/200 μm and LG=40 μm, and about 2.6 times that of the device with W/LSD=800 μm/100 μm and LG=20 μm, thereby validating the correctness of the theoretical calculations. Moreover, the fabricated HEMT devices were capable of detecting cortisol concentrations ranging from 10 fM to 100 μM in 1×PBS, demonstrating specificity to cortisol and good linearity, with R2 values of 0.98456, 0.98038, and 0.99232, respectively. The detection results verified the outcomes of theoretical analysis. This paper systematically investigates the integration of theoretical analysis with the practical application of AlGaN/GaN HEMT devices, providing a new method to enhance sensitivity in biochemical detection using HEMT devices.