bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biobibliometric profiling: An examination of multifaceted approaches to scholarship
Authors: Sugimoto Cassidy R. , Cronin Blaise 
Published: November 2011

AbstractWe conducted a fine‐grained prosopography of six distinguished information scientists to explore commonalities and differences in their approaches to scholarly production at different stages of their careers. Specifically, we gathered data on authors' genre preferences, rates and modes of scholarly production, and coauthorship patterns. We also explored the role played by gender and place in determining mentoring and collaboration practices across time. Our biobibliometric profiles of the sextet reveal the different shapes a scholar's career can take. We consider the implications of our findings for new entrants into the academic marketplace.
Host cell protein dynamics in the supernatant of a mAb producing CHO cell line
Authors: Tait A.S. , Hogwood C.E.M. , Smales C.M. , Bracewell D.G. 
Published: November 2011

AbstractThe characterization of host cell protein (HCP) content during the production of therapeutic recombinant proteins is an important aspect in the drug development process. Despite this, key components of the HCP profile and how this changes with processing has not been fully investigated. Here we have investigated the supernatant HCP profile at different times throughout culture of a null and model GS‐CHO monoclonal antibody producing mammalian cell line grown in fed‐batch mode. Using 2D‐PAGE and LC‐MS/MS we identify a number of intracellular proteins (e.g., protein disulfide isomerise; elongation factor 2; calreticulin) that show a significant change in abundance relative to the general increase in HCP concentration observed with progression of culture. Those HCPs that showed a significant change in abundance across the culture above the general increase were dependent on the cell line examined. Further, our data suggests that the majority of HCPs in the supernatant of the cell lines investigated here arise through lysis or breakage of cells, associated with loss in viability, and are not present due to the secretion of protein material from within the cell. SELDI‐TOF and principal components analysis were also investigated to enable rapid monitoring of changes in the HCP profile. SELDI‐TOF analysis showed the same trends in the HCP profile as observed by 2D‐PAGE analysis and highlighted biomarkers that could be used for process monitoring. These data further our understanding of the relationship between the HCP profile and cell viability and may ultimately enable a more directed development of purification strategies and the development of cell lines based upon their HCP profile. Biotechnol. Bioeng. 2012; 109:971–982. © 2011 Wiley Periodicals, Inc.
Population‐based modeling of the progression of apoptosis in mammalian cell culture
Authors: Meshram Mukesh , Naderi Saeideh , McConkey Brendan , Budman Hector , Scharer Jeno , Ingalls Brian 
Published: November 2011

AbstractThe production of biopharmaceuticals from mammalian cell culture is hindered by apoptosis, which is the primary cause of cell death in these cultures. As a tool for optimization of culture yield, this study presents a population‐based model describing the progression of apoptosis in a monoclonal antibody (mAb)‐producing Chinese hamster ovary (CHO) cell culture. Because mAb production does not cease when apoptosis begins, the model was designed to incorporate subpopulations at various stages in the progression of apoptosis. The model was validated against intracellular measurements of caspase activity as well as cell density, nutrient levels, and toxic metabolites. Since the specific details of apoptotic mechanisms have not been elucidated in this cell line, we employed a model comparison analysis that suggests the most plausible pathways of activation. Biotechnol. Bioeng. 2012; 109:1193–1204. © 2011 Wiley Periodicals, Inc.
The Best Interest of the Child‐Questionnaire, reliability and validity: Preliminary data on the question ‘where to live after detention or secure treatment?’
Authors: Kalverboer Margrite , Ten Brummelaar Mijntje , Post Wendy , Zijlstra Elianne , Harder Annemiek , Knorth Erik 
Published: November 2011

ABSTRACTBackgroundThe Best Interest of the Child‐Questionnaire (BIC‐Q) has been designed as an instrument for screening the quality of the rearing situation of children with behavioural problems or delinquency. It is intended to aid legal decisions in juvenile and family law.AimsThe aim of the study was to establish the reliability and validation of the BIC‐Q.MethodsRecords of 83 children in detention or secure treatment centres and 58 children with no delinquent behaviours were rated by trained researchers. Interrater reliability was tested with a sub‐sample of 31 of the former. Content validity was evaluated across the whole group, using Cronbach's alpha to check internal consistency, Spearman's rho to examine correlations and explorative principal component analysis (PCA) to test the extent to which variance in the 14 underlying conditions could be accounted for by a single factor ‘quality of rearing’.ResultsInterrater reliability was good (r = 0.89). The PCA lent support to the content validity of the questionnaire with four factors, which together explained 66% of the variance in child rearing: (1) attachment and bonding; (2) rules and provisions; (3) health care and physical care in the family context; and (4) care and models provided for in the societal environment.ConclusionsThe BIC‐Q is a reliable and valid measure of the overall quality of child rearing.Implications for practicePreliminary results indicate that the BIC‐Q may be applied to support court decisions on where the child should live after detention or secure treatment. Copyright © 2011 John Wiley & Sons, Ltd.
A wave generation toolbox for the open‐source CFD library: OpenFoam®
Authors: Jacobsen Niels G. , Fuhrman David R. , Fredsøe Jørgen 
Published: November 2011

SUMMARYThe open‐source CFD library OpenFoam® contains a method for solving free surface Newtonian flows using the Reynolds averaged Navier–Stokes equations coupled with a volume of fluid method. In this paper, it is demonstrated how this has been extended with a generic wave generation and absorption method termed ‘wave relaxation zones’, on which a detailed account is given. The ability to use OpenFoam for the modelling of waves is demonstrated using two benchmark test cases, which show the ability to model wave propagation and wave breaking. Furthermore, the reflection coefficient from outlet relaxation zones is considered for a range of parameters. The toolbox is implemented in C++, and the flexibility in deriving new relaxation methods and implementing new wave theories along with other shapes of the relaxation zone is outlined. Subsequent to the publication of this paper, the toolbox has been made freely available through the OpenFoam‐Extend Community. Copyright © 2011 John Wiley & Sons, Ltd.
Nerve transfers for restoration of upper extremity motor function in a child with upper extremity motor deficits due to transverse myelitis: Case report
Authors: Dorsi Michael J. , Belzberg Allan J. 
Published: November 2011

AbstractTransverse myelitis (TM) may result in permanent neurologic dysfunction. Nerve transfers have been developed to restore function after peripheral nerve injury. Here, we present a case report of a child with permanent right upper extremity weakness due to TM that underwent nerve transfers. The following procedures were performed: double fascicle transfer from median nerve and ulnar nerve to the brachialis and biceps branches of the musculocutaneous nerve, spinal accessory to suprascapular nerve, and medial cord to axillary nerve end‐to‐side neurorraphy. At 22 months, the patient demonstrated excellent recovery of elbow flexion with minimal improvement in shoulder abduction. We propose that the treatment of permanent deficits from TM represents a novel indication for nerve transfers in a subset of patients. © 2011 Wiley Periodicals, Inc. Microsurgery, 2012.
Reconstruction of the larynx and aryepiglottic fold using a free radial forearm tendocutaneous flap after partial laryngopharyngectomy: A case report
Authors: Mihara Makoto , Iida Takuya , Hara Hisako , Hayashi Yohei , Yamamoto Takumi , Mitsunaga Narushima , Todokoro Takeshi , Uchida Gentaro , Koshima Isao 
Published: November 2011

AbstractThe patient was a 62‐year‐old man with chief complaints of pharyngeal pain and dysphagia. He was diagnosed with pyriform sinus poorly differentiated squamous cell carcinoma T3N0M0 (Stage II) and underwent partial laryngopharyngectomy, lymphadenectomy in the right neck, tracheostomy, and reconstruction of the larynx and aryepiglottic fold with a free radial forearm flap and the associated vascularized palmaris longus tendon. No particular problems occurred after surgery, and swallowing and articulation functions were successfully recovered. A free jejunum transfer is the first choice for reconstruction of a defect after partial hypopharyngectomy, but reconstruction of the supracricoid complex structure of the larynx using a free jejunum transfer after partial laryngopharyngectomy may lead to aspiration of intestinal fluids. In this case, we performed functional reconstruction of the laryngopharyngeal defect using a free radial forearm flap including a vascularized tendon of the palmaris longus, and satisfactory postoperative function was achieved. We believe that the key to successful functional recovery after partial laryngopharyngectomy is establishment of the three‐dimensional complex structure of the arytenoid and aryepiglottic fold. © 2011 Wiley Periodicals, Inc. Microsurgery, 2012.
Impact of vasopressors on outcomes in head and neck free tissue transfer
Authors: Harris Luke , Goldstein David , Hofer Stefan , Gilbert Ralph 
Published: November 2011

AbstractObjectives/Hypothesis: The primary objective of the study was to determine the frequency of intraoperative vasopressor administration among patients undergoing free tissue transfer for head and neck reconstruction, and the secondary objective was to determine the impact of intraoperative vasopressor on free tissue transfer outcomes, including the impact of cumulative vasopressor dose and timing of intraoperative vasopressor administration. Study design/Methods: A retrospective review was performed of all patients undergoing free tissue transfer for head and neck reconstruction at the University Health Network between 2004 to 2008. Results: From 2004 to 2008 inclusive, 485 patients underwent 496 free tissue transfers for head and neck reconstruction. The complete failure rate was 2.2% (11 of 485 patients). The partial failure rate was 1.4%, and the operative take‐back rate for venous congestion or arterial thrombosis was 1.6%. This gave a total major flap complication rate of 5.2%, which was used as the primary free tissue transfer outcome measure. Of the 485 patients who underwent free tissue transfer, 320 (66.0%) received intraoperative vasopressor. Of these patients, the majority (97.5%) received phenylephrine and/or ephedrine. There was no significant relationship between receiving intraoperative vasopressor and major free flap complications, which were defined as complete failure, partial failure, or operative take‐back for venous congestion or arterial thrombosis. Conclusion: Intraoperative vasopressors are used routinely in free tissue transfer for the reconstruction of head and neck defects. The use of intraoperative vasopressors does not appear to adversely affect free tissue transfer outcomes. © 2011 Wiley Periodicals, Inc. Microsurgery, 2012.
Linearization estimates of the backward errors for least squares problems
Authors: Liu Xin‐Guo , Zhao Na 
Published: November 2011

SUMMARYWe study the linearization method to estimate the backward error of approximate solutions to several least squares problems, including the scaled total least squares (STLS) problem, the equality constrained least squares (LSE) problem, and the least squares problem over a sphere (LSS). For the STLS problem, we present several new results about the linearization estimate derived by Chang and Titley‐Peloquin. For the LSE and the LSS problems, we derive linearization estimates of the backward errors and compare them with existing backward error bounds by numerical tests. Our experiments show that the linearization estimates are good enough approximations of the backward errors as the approximate solution approaches the exact one. Copyright © 2011 John Wiley & Sons, Ltd.
Electromagnetic properties of Fe3O4‐functionalized graphene and its composites with a conducting polymer
Authors: Tung Tran Thanh , Feller Jean‐Francois , Kim TaeYoung , Kim Hyeongkeun , Yang Woo Seok , Suh Kwang S. 
Published: November 2011

AbstractHybrid materials of Fe3O4‐decorated reduced graphene oxide (Fe3O4‐RGO) and poly(3,4‐ethylenedioxythiophene) (PEDOT) were prepared by poly(ionic liquid)‐mediated hybridization. In this hybrid material, poly(ionic liquid) was found to perform multiple roles for: (1) stabilizing Fe3O4‐RGO against aggregation in the reaction medium, (2) transferring Fe3O4‐RGO nanomaterials from aqueous into organic phase, and (3) associating Fe3O4‐RGO nanomaterials with PEDOT. The hybrid materials of Fe3O4‐RGO with PEDOT showed the lowest surface resistivity of 80 Ω sq−1 at an RGO‐Fe3O4 loading of 1 wt %, and exhibited superparamagnetic behavior with an electromagnetic interference shielding effectiveness of 22 dB. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012
Qlaira: first COC licensed for heavy menstrual bleeding
Authors: Chaplin Steve , Briggs Paula 
Published: November 2011

AbstractQlaira (estradiol valerate plus dienogest) is the first combined oral contraceptive to gain a licence for the treatment of heavy menstrual bleeding in women without organic pathology who desire oral contraception. In our New products review Steve Chaplin presents the clinical data relating to its efficacy and adverse events, and Dr Paula Briggs discusses its place in the treatment of heavy menstrual bleeding. Copyright © 2011 Wiley Interface Ltd
Variational assimilation of cloud fraction in the operational Met Office Unified Model
Authors: Renshaw Richard , Francis Peter N. 
Published: November 2011

AbstractShort‐range forecasts of cloud cover are considered an important part of providing a public weather service in the UK. These require accurate initial conditions. Satellite imagery and surface cloud reports provide observations of cloud but using these to initialize forecast models is not easy. Cloud data are not well suited to variational analysis schemes. This paper describes how the Met Office variational analysis has been adapted to use such data. Results show that cloud observations can be usefully assimilated. Copyright © 2011 British Crown copyright, the Met Office. Published by John Wiley & Sons Ltd.
A Pilot Study: Short‐term Reduction in Salivary Cortisol Following Low Level Physical Exercise and Relaxation among Adolescents and Young Adults on the Autism Spectrum
Authors: Hillier Ashleigh , Murphy Deirdra , Ferrara Cynthia 
Published: November 2011

AbstractMany adolescents and young adults with autism spectrum disorders (ASD) experience high levels of stress and anxiety. The purpose of this pilot study was to examine whether physical exercise and relaxation could reduce stress and anxiety among those with ASD. Salivary cortisol levels were collected before and after each of three sessions during an 8‐week exercise programme. Our findings showed a significant reduction in cortisol at the end of the sessions compared with the beginning. This was supported by a self‐report anxiety measure. Although reductions in these stress measures were not sustained over time, our results highlight the potential of exercise and relaxation for improving symptoms of stress. Future studies are needed which examine longer term reductions in stress following physical exercise interventions. Copyright © 2011 John Wiley & Sons, Ltd.
Free‐weighting matrices‐based robust wide‐area FACTS control design with considering signal time delay for stability enhancement of power systems
Authors: Liu Fang , Yokoyama Ryuichi , Zhou Yicheng , Wu Min 
Published: November 2011

AbstractThis paper presents a free‐weighting matrix (FWM) method based on linear control design approach for the wide‐area robust damping (WARD) controller associated with flexible AC transmission system (FACTS) device to improve the dynamical performance of the large‐scale power systems. First, the linearized reduced‐order plant model is established, which efficiently considers the time delay of the remote feedback signals transmitted by wide‐area measurement systems. Then, based on the robust control theory, the design of the FACTS‐WARD controller is formulated as the standard control problem on delay‐dependent state‐feedback robust control, which is described by a set of linear matrix inequality constraints. Furthermore, in order to obtain the optimal control parameters that can endure the maximum time delay, a FWM approach is proposed to solve the time‐dependent problem of the time‐delay system. Meanwhile, an iterative algorithm based on cone complementary linearization is presented to search out the optimal control parameters. Finally, the nonlinear simulations on the 2‐area 4‐machine and the 5‐area 16‐machine test systems are performed, to evaluate the control performance of the proposed robust wide‐area time‐delay control approach. © 2011 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
Variation Within Dialects: A Case of Cajun/Creole Influence Within Child SAAE and SWE
Authors: Oetting Janna B. , Garrity April Wimberly 
Published: November 2011

Purpose
This study examined whether child speakers of Southern African American English (SAAE) and Southern White English (SWE) who were also perceived by some listeners to present a Cajun/Creole English (CE) influence within their dialects produced elevated rates of 6 phonological and 5 morphological patterns of vernacular relative to other SAAE- and SWE-speaking children.

Method
A group comparison design was followed. The data were listener judgments, 1-min audiotaped excerpts of conversational speech, and transcribed language samples from 93 children (31 classified as specifically language impaired while the others were classified as either aged-matched or language-matched controls; 13 classified as SWE with CE, 40 classified as SWE only, 18 classified as SAAE with CE, and 22 classified as SAAE only).

Results
Results indicated that children with a CE influence produced elevated rates of vernacular phonology relative to the others, with 2 patterns (nonaspirated stops and glide reduction) showing statistically significant group differences. In contrast, the children’s use of vernacular morphology was unrelated to their CE status, but was instead related to their primary dialect (SWE vs. SAAE) and language ability classification (impaired vs. normal).

Conclusions
The findings highlight the role of phonology in listeners' perceptions of dialect variation within 2 nonmainstream dialects (SWE and SAAE). The findings also demonstrate the ways phonological and morphological forms of vernacular can be independently influenced by different types of child variables.
Mutant LGI1 inhibits seizure‐induced trafficking of Kv4.2 potassium channels
Authors: Smith Stephen E. P. , Xu Lin , Kasten Michael R. , Anderson Matthew P. 
Published: November 2011

J. Neurochem. (2012) 120, 611–621.AbstractActivity‐dependent redistribution of ion channels mediates neuronal circuit plasticity and homeostasis, and could provide pro‐epileptic or compensatory anti‐epileptic responses to a seizure. Thalamocortical neurons transmit sensory information to the cerebral cortex and through reciprocal corticothalamic connections are intensely activated during a seizure. Therefore, we assessed whether a seizure alters ion channel surface expression and consequent neurophysiologic function of thalamocortical neurons. We report a seizure triggers a rapid (< 2 h) decrease of excitatory postsynaptic current (EPSC)‐like current‐induced phasic firing associated with increased transient A‐type K+ current. Seizures also rapidly redistributed the A‐type K+ channel subunit Kv4.2 to the neuronal surface implicating a molecular substrate for the increased K+ current. Glutamate applied in vitro mimicked the effect, suggesting a direct effect of glutamatergic transmission. Importantly, leucine‐rich glioma‐inactivated‐1 (LGI1), a secreted synaptic protein mutated to cause human partial epilepsy, regulated this seizure‐induced circuit response. Human epilepsy‐associated dominant‐negative‐truncated mutant LGI1 inhibited the seizure‐induced suppression of phasic firing, increase of A‐type K+ current, and recruitment of Kv4.2 surface expression (in vivo and in vitro). The results identify a response of thalamocortical neurons to seizures involving Kv4.2 surface recruitment associated with dampened phasic firing. The results also identify impaired seizure‐induced increases of A‐type K+ current as an additional defect produced by the autosomal dominant lateral temporal lobe epilepsy gene mutant that might contribute to the seizure disorder.
Radio‐opaque fecal impaction and pseudo‐occlusion in a dialyzed patient taking lanthanum carbonate
Authors: Muller Clotilde , Muller Sandrine , Sissoko Aicha , Klein Alexandre , Faller Bernadette , Chantrel Francois 
Published: November 2011

AbstractLanthanum therapy is an efficient therapy of hyperphosphoremia by chelating phosphore in the digestive tract. Lanthanum is a silvery white metallic element that belongs to group 3 of the periodic table. This drug is lightly absorbed and has low water solubility. It should be borne in mind that abdominal X‐rays of patients taking lanthanum carbonate may have a radio‐opaque appearance typical of imaging agents. This characteristic is suggested to confirm adherence of the patient by doing an abdominal X‐ray. We describe in our case a particular good compliant patient with slow digestive transit, which ends by pseudo‐occlusion.
An optimal Earth Trojan asteroid search strategy
Authors: Todd M. , Tanga P. , Coward D. M. , Zadnik M. G. 
Published: November 2011

Abstract
Trojan asteroids are minor planets that share the orbit of a planet about the Sun and librate around the L4 or L5 Lagrangian points of stability. They are important solar-system fossils because they carry information on early Solar system formation, when collisions between bodies were more frequent. Discovery and study of terrestrial planet Trojans will help constrain models for the distribution of bodies and interactions in the inner Solar system. Since the discovery of the first outer planet Trojan in 1906, several thousand Jupiter Trojans have been found. Of the terrestrial planets, there are four known Mars Trojans, and one Earth Trojan has been recently discovered. We present a new model that constrains optimal search areas, and imaging cadences for narrow and wide-field survey telescopes including the Gaia satellite for the most efficient use of telescope time to maximize the probability of detecting additional Earth Trojans.