bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stratifying risk of disease in haematuria patients using machine learning techniques to improve diagnostics
Authors: Drożdż Anna , Duggan Brian , Ruddock Mark W. , Reid Cherith N. , Kurth Mary Jo , Watt Joanne , Irvine Allister , Lamont John , Fitzgerald Peter , O’Rourke Declan , Curry David , Evans Mark , Boyd Ruth , Sousa Jose 
Published: May 2024

BackgroundDetailed and invasive clinical investigations are required to identify the causes of haematuria. Highly unbalanced patient population (predominantly male) and a wide range of potential causes make the ability to correctly classify patients and identify patient-specific biomarkers a major challenge. Studies have shown that it is possible to improve the diagnosis using multi-marker analysis, even in unbalanced datasets, by applying advanced analytical methods. Here, we applied several machine learning algorithms to classify patients from the haematuria patient cohort (HaBio) by analysing multiple biomarkers and to identify the most relevant ones.Materials and methodsWe applied several classification and feature selection methods (k-means clustering, decision trees, random forest with LIME explainer and CACTUS algorithm) to stratify patients into two groups: healthy (with no clear cause of haematuria) or sick (with an identified cause of haematuria e.g., bladder cancer, or infection). The classification performance of the models was compared. Biomarkers identified as important by the algorithms were also analysed in relation to their involvement in the pathological processes.ResultsResults showed that a high unbalance in the datasets significantly affected the classification by random forest and decision trees, leading to the overestimation of the sick class and low model performance. CACTUS algorithm was more robust to the unbalance in the dataset. CACTUS obtained a balanced accuracy of 0.747 for both genders, 0.718 for females and 0.803 for males. The analysis showed that in the classification process for the whole dataset: microalbumin, male gender, and tPSA emerged as the most informative biomarkers. For males: age, microalbumin, tPSA, cystatin C, BTA, HAD and S100A4 were the most significant biomarkers while for females microalbumin, IL-8, pERK, and CXCL16.ConclusionsCACTUS algorithm demonstrated improved performance compared with other methods such as decision trees and random forest. Additionally, we identified the most relevant biomarkers for the specific patient group, which could be considered in the future as novel biomarkers for diagnosis. Our results have the potential to inform future research and provide new personalised diagnostic approaches tailored directly to the needs of the individuals.
Exploring the putative microRNAs cross-kingdom transfer in Solanum lycopersicum-Meloidogyne incognita interactions
Authors: Leonetti Paola , Dallera Debora , De Marchi Davide , Candito Pamela , Pasotti Lorenzo , Macovei Anca 
Published: May 2024

IntroductionPlant-pathogen interaction is an inexhaustible source of information on how to sustainably control diseases that negatively affect agricultural production. Meloidogyne incognita is a root-knot nematode (RKN), representing a pest for many crops, including tomato (Solanum lycopersicum). RKNs are a global threat to agriculture, especially under climate change, and RNA technologies offer a potential alternative to chemical nematicides. While endogenous microRNAs have been identified in both S. lycopersicum and M. incognita, and their roles have been related to the regulation of developmental changes, no study has investigated the miRNAs cross-kingdom transfer during this interaction.MethodsHere, we propose a bioinformatics pipeline to highlight potential miRNA-dependent cross-kingdom interactions between tomato and M. incognita.ResultsThe obtained data show that nematode miRNAs putatively targeting tomato genes are mostly related to detrimental effects on plant development and defense. Similarly, tomato miRNAs putatively targeting M. incognita biological processes have negative effects on digestion, mobility, and reproduction. To experimentally test this hypothesis, an in vitro feeding assay was carried out using sly-miRNAs selected from the bioinformatics approach. The results show that two tomato miRNAs (sly-miRNA156a, sly-miR169f) soaked by juvenile larvae (J2s) affected their ability to infect plant roots and form galls. This was also coupled with a significant downregulation of predicted target genes (Minc11367, Minc00111), as revealed by a qRT-PCR analysis.DiscussionsTherefore, the current study expands the knowledge related to the cross-kingdom miRNAs involvement in host-parasite interactions and could pave the way for the application of exogenous plant miRNAs as tools to control nematode infection.
Three Cube Packing for All Dimensions
Authors: Adamko Peter 
Published: May 2024

Let Vn(d) denote the least number, such that every collection of n d-cubes with total volume 1 in d-dimensional (Euclidean) space can be packed parallelly into some d-box of volume Vn(d). We show that V3(d)=r1−dd if d≥11 and V3(d)=1r+1rd+1r−rd+1 if 2≤d≤10, where r is the only solution of the equation 2(d−1)kd+dkd−1=1 on 22,1 and (k+1)d(1−k)d−1dk2+d+k−1=kddkd+1+dkd+kd+1 on 22,1, respectively. The maximum volume is achieved by hypercubes with edges x, y, z, such that x=2rd+1−1/d, y=z=rx if d≥11, and x=rd+(1r−r)d+1−1/d, y=rx, z=(1r−r)x if 2≤d≤10. We also proved that only for dimensions less than 11 are there two different maximum packings, and for all dimensions greater than 10, the maximum packing has the same two smallest cubes.
FAKTOR-FAKTOR YANG BERHUBUNGAN TERJADINYA LASERASI PERINIUM PADA SAAT PERSALINAN
Authors: Florentina Kusyanti Floren , Putri Kornelia , Anisah Anisah 
Published: May 2024

Latar Belakang: Periode Kehamilan dan persalinan adalah sangat berhubungan dengan kehidupan seorang Wanita.Persalinan adalah proses yang sangat memerlukan pendampingan,pengawasan sehingga proses persalinan ini bisa berjalan normal.Persalinan adalah suatu proses pengeluaran hasil konsepsi dari suatu pasangan suami istri,Dimana proses ini harus diperlukan pengawasan dan pendampingan,untuk menjaga agar saat persalinan perinium tetap utuh maka ada beberapa usaha dari pasien dan bidan,selain itu laserasi perinium juga banyak factor yang mempengaruhinya. Tujuan untuk mengetahui factor yang bisa berhubungan terjadi laserasi perinium pada saat persalinan.Metode: Penelitian ini dilaksanakan di PMB Kuswatiningsih ,Desain yang dipakai pasa penelilian ini adalah kuantitatif dengan pendekatan cros sectional .Tehnik pengumpulan data dengan Total sampling, Sampling jumlah sampel 125 responden .Data diambil pada pasien yang melahirkan di PMB Kuswatiningsih mulai bulan Januari 2023 sampai bulan Juli 2023.Hasil: Jumlah 125 responden,responden adalah semua ibu yang melahirkan mulai bulan januari sampai bulan juli 2023,karakteristik responden umur 26-35 sebesar 55,2%,Pendidikan menegah 61,6%,Pekerjaan IRT 51,2%,paritas anak 1 yaitu 43,2%,tinggi badan 151-155 sebesar 42,4%.Faktor lain laserasi derajat 2 dan diheating sebesar 82,4%,BBL lebih 3000 gram sebesar 52,8%.hubungan antara paritas dengan laserasi derajat 2 sebesar 92,5%,BBL > 3000 gram dengan laserasi derajat 2 sebesar 83,3%,Tinggi badan dengan laserasi pada TB 151-155 terjadi laserasi derajat 2 sebesar 84,9%Kesimpulan: ada hubungan antara paritas dengan laserasi,ada hubungan antara BBL dengan laserasi.
PENGARUH PENERAPAN TERAPI MEDITASI MUSIK RELIGIUS TERHADAP PENURUNAN TEKANAN DARAH PADA PENDERITA HIPERTENSI LANJUT USIA DI POSYANDU LANSIA DESA TAMBAKSELO
Authors: Riniasih Wahyu , Utami Putri Madina 
Published: May 2024

Latar Belakang: penyakit tidak menular (PTM) yang semakin meningkat salah satunya yaitu hipertensi. Menurut dinkes kab. Grobogan Presentase di daerah pedesaan (38,11%) > perkotaan (37,01%) Data yang diambil pada 1 febuari 2023 Prevalensi hipertensi lansia di posyandu lansia desa Tambakselo sebesar 27% penderita hipertensi. Meditasi musik religius menghantarkan partikel yang disebut nitrik oksida di pembuluh darah yang berfungsi mengendurkan otot polos pembuluh darah dan berperan dalam mengatur aliran darah melalui jaringan dan menjaga tekanan peredaran darah di dalam batas normal.Metodologi: Penelitian ini merupakan penelitian kuantitatif menggunakan quisy Eksperiment dan desain pretest and posttest with control grup design, Teknik sempling yang digunakan adalah random Sampling dengan 38 responden.Hasil: Berdasarkan SPSS menggunakan Uji Paired Sample T Test.didapatkan nilai p value 0.000 dikarenakan <0.05 maka dapat disimpulkan Ha diterima Ho ditolak. Sehingga dapat disimpulkan ada Pengaruh penerapan terapi meditasi musik religius terhadap penurunan tekanan darah pada penderita hipertensi lanjut usia diposyandu lansia desa Tambakselo.Kesimpulan: Berdasarkan dari penelitian ada Pengaruh penerapan terapi meditasi musik religius terhadap penurunan tekanan darah pada penderita hipertensi lanjut usia diposyandu lansia desa Tambakselo.Kata Kunci: Meditasi musik religius, tekanan darah, HipertensiKepustakaan: 41 (2016-2022)
Efficacy and Safety of Sarclav in the Treatment of Acute Otitis Media in Children
Authors: Abhay Kumar Singh, Harsimrat Singh, Himani Singh  
Published: May 2024

Background
Acute otitis media (AOM) is a community-acquired respiratory tract infection in childhood frequently encountered by primary-care physicians and can cause a significant morbidity. Increasing bacterial resistance has led to concern about the current options for empirical antibiotic treatment and has prompted a search for effective treatments.
Objectives
To evaluate the clinical efficacy and safety of Sarclav (cefpodoxime proxetil) in the treatment of children with acute otitis media.
Patients and Method
A prospective, multicenter study was conducted on 1380 children aged from 1 to 13 years with AOM who were prescribed a 5–10 day course of Sarclav (cefpodoxime proxetil) (8 mg/kg/day). Patients were followed-up after 7–14 days from baseline visit. Efficacy was assessed by the percentage of patients with clinical cure, improvement or failure at the follow-up visit. Safety was evaluated by recording the occurrence and severity of any adverse events and by the physicians’ and patients’ assessment of overall tolerability.
Results
Clinically, 82.5% of patients were cured, 16.4% were improved and there was failure of therapy in 1.1% of the patients. The overall combined cure and improvement rate of all related signs and symptoms was 98.9%. Adverse events, diarrhea and skin rash, were reported by only 16 patients (1.2%). The overall tolerability according to the physicians’ and patients’ assessment was excellent in 93.9% and 88.9%, respectively. Compliance was attained in 99.5% of patients.
Conclusion
Sarclav (cefpodoxime proxetil) is an effective, safe, well-tolerated antimicrobial agent for treatment of acute otitis media in children. It can be considered as an excellent choice for the empirical treatment of bacterial AOM.
PENERAPAN METODE PEER TEACHING DALAM UPAYA MENINGKATKAN HASIL BELAJAR PRAKTIKUM AKUNTANSI PERUSAHAAN JASA, DAGANG DAN MANUFAKTUR PADA SISWA KELAS XI AKL 3 SMKN 1 DUMAI TAHUN 2022
Authors: Misra Misra 
Published: May 2024

Penelitian ini bertujuan untuk meningkatkan hasil belajar Pratikum Akuntansi Perusahaan Jasa, Dagang dan Manufaktur dengan metode pembelajaran Peer Teaching. Adapun rumusan masalah yang telah disusun oleh peneliti adalah : “Apakah dengan menggunakan metode Peer Teaching dapat meningkatkan hasil belajar Pratikum Akuntansi Perusahaan Jasa, Dagang dan Manufaktur siswa Kelas XI AKL 3 SMK Negeri 1 Dumai, Penelitian ini dilaksanakan berupa penelitian tindakan kelas adalah tahun 2022, pada semester ganjil. Yang menjadi subjek penelitian ini adalah siswa Kelas XI AKL 3 sebanyak 35 orang siswa. Analisis data mengunakan analisis deskriptif kualitatif. Penelitian menentukan aspek-aspek yang diamati pada masing-masing indicator hasil belajar.
Hasil penelitian pada bab-bab yang telah dibahas dapat disimpulkan bahwa dengan menggunakan metode Peer teaching dapat meningkatkan hasil belajar siswa Kelas XI AKL 3 SMK Negeri 1 Dumai, mata pelajaran Akuntansi Perusahaan Jasa, Dagang dan Manufaktur pada pokok bahasan Praktikum Akuntansi Perusahaan Jasa, Dagang dan Manufaktur. Setelah dilakukan tidakan pada siklus I hasil belajar kognitif siswa meningkat hasil belajar siswa. skor dasar dengan rata-rata 68,71 meningkat pada Ulangan Harian I menjadi 82,05 dengan tingkat ketuntasan 97,14%. Pada Ulangan Harian II meningkat menjadi 90,18 dengan tingkat ketuntasan 100%. Maka diperoleh kenaikan hasil belajar dari ulangan I dan ulangan II yang sangat signifikan.
Upaya Meningkatkan Hasil Belajar Pembuatan Busana Industri Melalui Penerapan Metode Project Based Learning Pada Siswa Kelas XII Busana 2 Di SMK Negeri 3 Pekanbaru Tahun 2022
Authors: Habean Bolita Roseria 
Published: May 2024

Penelitian ini bertujuan untuk meningkatkan hasil belajar Pembuatan Busana Industri melalui penerapan metode project based learning. Adapun rumusan masalah yang telah disusun oleh peneliti adalah : “apakah hasil belajar siswa kelas XII Busana 2 SMKN 3 Pekanbaru pada mapel Pembuatan Busana Industri dapat meningkat dengan diterapkannya metode pembelajaran project based learning?. Peneltian ini ditetapkan di SMK Negeri 3 Pekanbaru. Subjek penelitian dilakasanakan di Kelas XII Busana 2 sebanyak 36 orang siswa, waktu pelaksanaan penelitian tindakan kelas tahun 2022 pada semester ganjil. Analisis data mengunakan analisis deskriptif kualitatif. Penelitian menentukan aspek-aspek yang diamati pada masing-masing indikator hasil belajar.Hasil penelitian pada bab-bab yang telah dibahas dapat disimpulkan bahwa dengan menggunakan metode project based learning dapat meningkatkan hasil belajar siswa Kelas XII Busana 2 SMK Negeri 3 Pekanbaru, pada pokok bahasan Membuat Pola Rok secara manual dan digital dengan system grading dan Menjahit rok. Hasil penelitian menujukkan bahwa ada kenaikan nilai rata-rata dari skor dasar 76, pada siklus I rata-rata 81,32 dan pada siklus II nilai rata-rata 85,73 sehingga dilihat adanya kenaikan nilai yang signifikan dan semua siswa sebanyak 36 orang tuntas karena nilai hasil belajarnya di atas nilai KKM.
Penerapan Model Pembelajaran Number Heads Together Untuk Meningkatkan Hasil Belajar Pada Mata Pelajaran Administrasi Pajak Kelas XII Akl 1 SMKN 4 Pekanbaru Tahun Pelajaran 2022/2023
Authors: Meriati Meriati 
Published: May 2024

Penelitian ini adalah penelitian tindakan kelas. Penelitian yang didasari atas hasil belajar mata pelajaran Administrasi Pajak yang masih rendah dan kurangnya penerapan variasi model pembelajaran pada peserta didik kelas XII Akuntansi dan Keuangan Lembaga 1 di SMK Negeri 4 Pekanbaru tahun pelajaran 2022/202023. Maka digunakan kooperatif learning tipe Number Heads Together dalam metode Diskusi untuk meningkatkan hasil belajar peserta didik. Pengumpulan data penelitian menggunakan teknik observasi dan tes. Teknik analisis data yang digunakan yaitu deskriptif dan kuantitatif dalam bentuk prentase yang dibagi dalam kelompok pembelajaran.Hasil belajar diambil dari segi keaktifan, pendalaman materi presenatsi , keceriaan dan kreativitas peserta didik dalam presentasi pembahasan materi dan hasil tes (afektif, kognitif dan psikomotor), sehingga diperoleh hasil rata-rata keaktifan tinggi, keceriaan dan kreativitas baik serta terjadi peningkatan nilai rata-rata kelas sebesar 58,96%. Demikian halnya dengan ketuntasan klasikal juga yang mengalami peningkatan dari kegiatan sebesar 93,56%.Hasil penelitian menyimpulkan bahwa penerapan model pembelajaran Number Heads Together dapat meningkatkan hasil belajar siswa pada mata pelajaran pajak kelas XII Akuntansi dan Keuangan Lembaga 1 di SMKN 4 Pekanbaru
ReveaLLAGN 0: First Look at JWST MIRI Data of Sombrero and NGC 1052
Authors: Goold Kameron , Seth Anil , Molina Mallory , Ohlson David , Runnoe Jessie C. , Böker Torsten , Davis Timothy A. , Dumont Antoine , Eracleous Michael , Fernández-Ontiveros Juan Antonio , Gallo Elena , Goulding Andy D. , Greene Jenny E. , Ho Luis C. , Markoff Sera B. , Neumayer Nadine , Plotkin Richard M. , Prieto Almudena , Satyapal Shobita , van de Ven Glenn , Walsh Jonelle L. , Yuan Feng , Feldmeier-Krause Anja , Gültekin Kayhan , Hönig Sebastian , Kirkpatrick Allison , Lützgendorf Nora , Reines Amy E. , Strader Jay , Trump Jonathan R. , Voggel Karina T. 
Published: May 2024

Abstract
We present the first results from the Revealing Low-Luminosity Active Galactic Nuclei (ReveaLLAGN) survey, a JWST survey of seven nearby LLAGNs. We focus on two observations with the Mid-Infrared Instrument (MIRI)’s Medium-Resolution Spectrometer of the nuclei of NGC 1052 and Sombrero (NGC 4594/M104). We also compare these data to public JWST data of higher-luminosity AGNs, NGC 7319 and NGC 7469. JWST clearly separates the AGN spectrum from the galaxy light even in Sombrero, the faintest target in our survey; the AGN components have very red spectra. We find that the emission-line widths in both NGC 1052 and Sombrero increase with increasing ionization potential, with FWHM > 1000 km s−1 for lines with ionization potential ≳ 50 eV. These lines are also significantly blueshifted in both LLAGNs. The high-ionization-potential lines in NGC 7319 show neither broad widths nor significant blueshifts. Many of the lower-ionization-potential emission lines in Sombrero show significant blue wings extending >1000 km s−1. These features and the emission-line maps in both galaxies are consistent with outflows along the jet direction. Sombrero has the lowest-luminosity high-ionization-potential lines ([Ne v] and [O iv]) ever measured in the mid-infrared, but the relative strengths of these lines are consistent with higher-luminosity AGNs. On the other hand, the [Ne v] emission is much weaker relative to the [Ne iii] and [Ne ii] lines of higher-luminosity AGNs. These initial results show the great promise that JWST holds for identifying and studying the physical nature of LLAGNs.
Distribution and Properties of Molecular Gas toward the Monoceros OB1 Region
Authors: Zhuang Zi , Su Yang , Zhang Shiyu , Chen Xuepeng , Yan Qing-Zeng , Feng Haoran , Sun Li , Xu Xiaoyun , Sun Yan , Zhou Xin , Wang Hongchi , Yang Ji 
Published: May 2024

Abstract
We perform a comprehensive CO study toward the Monoceros OB1 (Mon OB1) region based on the Milky Way Imaging Scroll Painting survey at an angular resolution of about 50″. The high-sensitivity data, together with the high dynamic range, show that molecular gas in the 8° × 4° region displays complicated hierarchical structures and various morphology (e.g., filamentary, cavity-like, shell-like, and other irregular structures). Based on Gaussian decomposition and clustering for 13CO data, a total of 263 13CO structures are identified in the whole region, and 88% of raw data flux is recovered. The dense gas with relatively high column density from the integrated CO emission is mainly concentrated in the region where multiple 13CO structures are overlapped. Combining the results of 32 large 13CO structures with distances from Gaia DR3, we estimate an average distance of

729

−
45

+
45

pc

for the giant molecular cloud (GMC) complex. The total mass of the GMC complex traced by 12CO, 13CO, and C18O is 1.1 × 105
M
⊙, 4.3 × 104
M
⊙, and 8.4 × 103
M
⊙, respectively. The dense gas fraction shows a clear difference between Mon OB1 GMC East (12.4%) and Mon OB1 GMC West (3.3%). Our results show that the dense gas environment is closely linked to the nearby star-forming regions. On the other hand, star-forming activities have a great influence on the physical properties of the surrounding molecular gas (larger velocity dispersion, higher temperatures, more complex velocity structures, etc.). We also discuss the distribution/kinematics of molecular gas associated with nearby star-forming activities.
On the Origin of the X-Ray Emission in Heavily Obscured Compact Radio Sources
Authors: Ł. Król Dominika , Sobolewska Małgosia , Stawarz Łukasz , Siemiginowska Aneta , Migliori Giulia , Principe Giacomo , Gurwell Mark A. 
Published: May 2024

Abstract
X-ray continuum emission of active galactic nuclei (AGNs) may be reflected by circumnuclear dusty tori, producing prominent fluorescence iron lines at X-ray frequencies. Here, we discuss the broadband emission of three radio-loud AGNs belonging to the class of compact symmetric objects (CSOs), with detected narrow Fe Kα lines. CSOs have newly born radio jets, forming compact radio lobes with projected linear sizes of the order of a few to hundreds of parsecs. We model the radio-to-γ-ray spectra of compact lobes in J1407+2827, J1511+0518, and J2022+6137, which are among the nearest and the youngest CSOs known to date, and are characterized by an intrinsic X-ray absorbing column density of N
H > 1023 cm−2. In addition to the archival data, we analyze the newly acquired Chandra X-ray Observatory and Submillimeter Array (SMA) observations, and also refine the γ-ray upper limits from Fermi Large Area Telescope monitoring. The new Chandra data exclude the presence of the extended X-ray emission components on scales larger than 1.″5. The SMA data unveil a correlation between the spectral index of the electron distribution in the lobes and N
H, which can explain the γ-ray quietness of heavily obscured CSOs. Based on our modeling, we argue that the inverse-Compton emission of compact radio lobes may account for the intrinsic X-ray continuum in all these sources. Furthermore, we propose that the observed iron lines may be produced by a reflection of the lobes’ continuum from the surrounding cold dust.
Dramatic Rebrightening of the Type-changing Stripped-envelope Supernova SN 2023aew
Authors: Sharma Yashvi , Sollerman Jesper , Kulkarni Shrinivas R. , Moriya Takashi J. , Schulze Steve , Barmentloo Stan , Fausnaugh Michael , Gal-Yam Avishay , Jerkstrand Anders , Ahumada Tomás , Bellm Eric C. , Das Kaustav K. , Drake Andrew , Fremling Christoffer , Hale David , Hall Saarah , Hinds K. R. , Jegou du Laz Theophile , Karambelkar Viraj , Kasliwal Mansi M. , Masci Frank J. , Miller Adam A. , Nir Guy , Perley Daniel A. , Purdum Josiah N. , Qin Yu-Jing , Rehemtulla Nabeel , Rich R. Michael , Riddle Reed L. , Rodriguez Antonio C. , Rose Sam , Somalwar Jean , Wise Jacob L. , Wold Avery , Yan Lin , Yao Yuhan 
Published: May 2024

Abstract
Multipeaked supernovae with precursors, dramatic light-curve rebrightenings, and spectral transformation are rare, but are being discovered in increasing numbers by modern night-sky transient surveys like the Zwicky Transient Facility. Here, we present the observations and analysis of SN 2023aew, which showed a dramatic increase in brightness following an initial luminous (−17.4 mag) and long (∼100 days) unusual first peak (possibly precursor). SN 2023aew was classified as a Type IIb supernova during the first peak but changed its type to resemble a stripped-envelope supernova (SESN) after the marked rebrightening. We present comparisons of SN 2023aew’s spectral evolution with SESN subtypes and argue that it is similar to SNe Ibc during its main peak. P-Cygni Balmer lines are present during the first peak, but vanish during the second peak’s photospheric phase, before Hα resurfaces again during the nebular phase. The nebular lines ([O i], [Ca ii], Mg i], Hα) exhibit a double-peaked structure that hints toward a clumpy or nonspherical ejecta. We analyze the second peak in the light curve of SN 2023aew and find it to be broader than that of normal SESNe as well as requiring a very high 56Ni mass to power the peak luminosity. We discuss the possible origins of SN 2023aew including an eruption scenario where a part of the envelope is ejected during the first peak and also powers the second peak of the light curve through interaction of the SN with the circumstellar medium.