bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uppermost Lower Aptian transgressive records in Mexico and Spain: chronostratigraphic implications for the Tethyan sequences
Authors: Moreno‐Bedmar Josep A. , Bover‐Arnal Telm , Barragán Ricardo , Salas Ramon 
Published: May 2012

Terra Nova, 24, 333–338, 2012AbstractA widespread marine transgression, which began at the very end of the Early Aptian, is well recorded in Mexico and Spain. In Mexico, this transgression was the most important Aptian transgressive event and its record begins in the Dufrenoyia justinae Zone, whereas in Spain the corresponding transgression is registered in the uppermost part of the Dufrenoyia furcata Zone. The basal age of this Tethyan transgression does not correspond exactly to any of the Lower Aptian third‐order sequences as reported in the literature. In Spain, the most important Aptian transgressive event was earlier, corresponding to the Tethyan sequence Ap3, which is well‐defined below this transgression reported herein. Consequently, it is possible to correlate this later transgressive event with the third‐order Ap4 sequence, which has commonly been attributed to the Upper Aptian. The available ammonoid data allow us to correct the basal age of the transgression, and to correlate the start of the ammonite record in Mexico with the Tethyan sequence Ap4.
Progress in epidermolysis bullosa: summary of a workshop in CILAD‐2010*
Authors: Salas‐Alanis Julio Cesar , Cepeda‐Valdes Rodrigo , Mellerio Jemima E. , Christiano Angela M. , Uitto Jouni 
Published: May 2012

AbstractBackground  Epidermolysis bullosa (EB), a group of blistering disorders, manifests with fragility of skin and mucous membranes, with considerable phenotypic variability. As many as 15 distinct genes have been shown to harbor mutations inheritable forms of EB. The types and combinations of mutations in these genes and their consequences at the mRNA and protein levels, when placed on the affected individuals’ genetic background and the external trauma, explain the spectrum of phenotypes encountered in this disorder.Methods  A group of eminent researchers and physician‐scientists convened in Cancún, Mexico, as part of the CILAD‐2010 Meeting, to discuss the most recent progress in diagnosis and management of patients with EB, with emphasis on development of novel treatment strategies.Results  The information on specific mutations in the candidate genes has been helpful in establishing genotype/phenotype correlations and has formed the basis for prenatal testing and preimplantation of genetic diagnosis for EB.Conclusions  In spite of the progress in molecular genetics of EB, there is no specific and effective treatment, and management of these patients continues to present tremendous clinical challenges. This overview summarizes the presentations and discussions in this international workshop.
A comparative study of the impairment of quality of life in Czech children with atopic dermatitis of different age groups and their families
Authors: Jiráková Anna , Vojáčková Naděžda , Göpfertová Dana , Hercogová Jana 
Published: May 2012

AbstractBackground  Atopic dermatitis (AD) still remains one of the most common childhood inflammatory skin diseases. As a chronic disease, it can have a physical and psychological effect on social functioning of the affected child as well as their family. The objective of this study was to evaluate the quality of life of children with AD of different age groups and their families.Methods  A total of 203 children with a diagnosis of AD from newborn to 18 years of age and 202 of their parents took part in our study (as one parent did not return the questionnaire). All participants, according to their age, completed the following questionnaires: Infants’ Dermatitis Quality of Life Index (IDQOL); Children’s Dermatology Life Quality Index (CDLQI) – text and cartoon version; and Dermatitis Family Impact questionnaire (DFI).Results  The mean total IDQOL score in our study was 8.18 (SD = 5.84, n = 120). The mean total CDLQI scores in the groups of children from 7 to 13 and from 14 to 18 years were 8.58 (SD = 4.98, n = 48) and 9.89 (SD = 5.26, n = 35). There was also a proven influence of the child’s AD on the quality of life of his parents with the mean score: 7.98 (SD = 6.41, n = 202).Conclusions  The study demonstrated and confirmed that AD significantly impairs the children’s quality of life in all age groups and also quality of life of their families. Such data give us patient‐oriented information that is of great importance for understanding the situation of individuals with AD and its influence on members of their family.
Atypical Hansen’s disease presenting as florid verrucous plaques on the lower extremities: a case report
Authors: Yuchua‐Guillen Angela , Dofitas Belen L. 
Published: May 2012

AbstractBackground  Verrucous leprosy is rare, with only 18 cases reported in the literature. Visceral involvement is frequent but often overlooked, causing significant morbidity and mortality.Case report  A 45‐year‐old Filipino male with a 16‐year history of hyperpigmented, hypoesthetic plaques, amputated digits, enlarged ulnar nerve, and cardiovascular congestion was diagnosed with Hansen’s disease – lepromatous type. He had multiple cauliflower‐like nodules and plaques with foul‐smelling discharge on the lower extremities presenting a diagnostic dilemma. After an exhaustive search, the causative agent for these verrucous nodules was confirmed to still be Mycobacterium leprae. In addition, he had glomerulonephritis, hypertension, congestive heart failure, deep venous thrombosis, neuritis, keratitis, and glaucoma, which are all complications of advanced leprosy and multiple attacks of erythema nodosum leprosum reactions.Conclusion  He was treated with a multibacillary regimen of Rifampicin, Dapsone, Clofazimine, and systemic corticosteroids, with remarkable improvement.
Sweaty skin, background and assessments
Authors: Noël Fanchon , Piérard‐Franchimont Claudine , Piérard Gérald E. , Quatresooz Pascale 
Published: May 2012

AbstractOverproduction of sweat, sweaty skin, and body malodors are felt unpleasant by many people in diverse social groups. This review summarizes the functional aspects of the eccrine, apocrine, and apoeccrine sweat glands as encountered in health and disease. A series of measuring methods are conveniently used to explore any trouble in sweat production. These include the gravimetric method, water evaporation quantification, skin staining procedures, dye injections, casting replicas, average electrometric assessments, and skin capacitance mapping / imaging (SCM). Qualitative assessment is provided by collection of sweat and volatile compounds followed by chromatographic analysis. At present, SCM appears to be the most valuable method for assessing the number of active glands and their individual sweat production by the eccrine and apoeccrine glands.
Co‐treatment with retinyl retinoate and a PPARα agonist reduces retinoid dermatitis
Authors: Kim Bora , Kim Jin E. , Kim Hyuk , Lee Joo D. , Choi Kang‐Yell , Lee Seung H. 
Published: May 2012

AbstractBackground  Retinoids have been used for the treatment of skin disorders such as acne, psoriasis, and photoaging. However, despite their beneficial effects, topical retinoids often cause severe local irritation called retinoid dermatitis. We previously developed a novel vitamin A derivative, retinyl retinoate, which induces less irritation and affords excellent tolerance. In this study, we examined whether co‐treatment with topical peroxisome proliferator‐activated receptor‐α (PPARα) agonists (e.g. WY14643) reduce retinoid dermatitis in hairless mouse skin.Methods  The effect of concomitant treatment with a PPARα agonist on retinoid dermatitis in hairless mouse epidermis was evaluated by measuring transepidermal water loss, epidermal histology, and cytokine expression.Results  Retinyl retinoate induced less severe retinoid dermatitis than retinoic acid. Topical application of a PPARα agonist improved the stratum corneum structure and function, reduced mRNA expression of interleukin (IL)‐1α, tumor necrosis factor‐α and IL‐8, and inhibited ear edema induced by retinoic acid or retinyl retinoate.Conclusions  Our results indicate that PPARα agonists can potentially be used to improve retinoid dermatitis. We suggest that co‐treatment with retinyl retinoate and a PPARα agonist may reduce or prevent detrimental alterations in retinoid‐treated skin.
Mohs micrographic surgery for verrucous carcinoma of the anogenital area: report of two cases
Authors: Casado‐Verrier Beatriz , Feltes‐Ochoa Rosa , Gómez‐Fernández Cristina , Feito‐Rodríguez Marta , Beato‐Merino María , Alonso‐Pacheco María Luisa 
Published: May 2012

AbstractBackground  Verrucous carcinoma (VC) of the anogenital area is an uncommon variant of squamous cell carcinoma (SCC). Its treatment is not standardized, but surgical excision must be performed if possible. The traditional approach does not distinguish between conventional SCC and VC, despite the extremely low metastatic potential of VC. Accordingly, most patients reported in the literature have been treated with radical surgery, including regional lymphadenectomy.Methods  We report two cases in order to describe the oncologic, functional, and esthetic results achieved by Mohs micrographic surgery (MMS) in the treatment of this disease.Results  Good functional and esthetic results were achieved in both patients. No local or nodal relapses were detected during the respective 12‐ and 27‐month follow‐ups.Conclusions  Early recognition of VC and the proper evaluation of deep biopsies will avoid misdiagnosis as SCC and may prevent the occurrence of unnecessary disfiguring interventions. The MMS technique may be considered as a surgical approach in genitoanal VC, although further research is required to confirm this.
ADULT syndrome due to an R243W mutation in TP63
Authors: Berk David R. , Armstrong Nicole L. , Shinawi Marwan , Whelan Alison J. 
Published: May 2012

AbstractAcro‐dermato‐ungual‐lacrimal‐tooth (ADULT) syndrome is a rare, autosomal dominant form of ectodermal dysplasia due to TP63 mutations. ADULT syndrome is much less common than the more classical forms of TP63‐associated ectodermal dysplasias, such as ectrodactyly–ectodermal dysplasia–cleft lip/palate (EEC) syndrome and ankyloblepharon–ectodermal defects–cleft lip/palate syndrome. ADULT syndrome is characterized by ectrodactyly, syndactyly, and excessive freckling, in addition to more typical ectodermal defects, including hypodontia, lacrimal duct anomalies, hypotrichosis, and onychodysplasia. Unlike some of the other TP63‐associated ectodermal dysplasias, ADULT syndrome lacks clefting and ankyloblepharon. Here, we report a three‐generation family with ADULT syndrome due to an R243W mutation in TP63, a mutation that has previously been described in one patient with ADULT syndrome and eight unrelated patients with EEC syndrome.
Factors associated with low physical activity levels following pediatric cardiac transplantation
Authors: Banks Laura , Dipchand Anne I. , Manlhiot Cedric , Millar Kyle , McCrindle Brian W. 
Published: May 2012

Banks L, Dipchand AI, Manlhiot C, Millar K, McCrindle BW. Factors associated with low physical activity levels following pediatric cardiac transplantation.Abstract:  Background: Objectively measured MVPA levels following pediatric cardiac transplantation are unknown despite physical health implications. We sought to determine factors associated with MVPA in a pediatric cohort who had undergone cardiac transplantation. Methods: Study assessments included maximal exercise testing (VO2max), accelerometry, and physical activity (HAES) and functional health status (CHQ‐PF50) questionnaires. Results: Participants (n = 20, 60% male, age: 11.8 ± 3.0 yr old) had a VO2max of 28.5 ± 6.8 mL/kg/min (%‐predicted: 65 ± 14%) and maximal heart rate of 154 ± 16 beats/min (%‐predicted: 73 ± 7.5%). Participants performed a median of 7.6 min/day (Q1 4.0 min/day, Q3 11.0 min/day) of MVPA. Each additional year of age at transplantation was associated with a decrease of 1.9 [1.0] min/day of MVPA (p = 0.07). Predicted VO2max, maximal power output, male sex, and age at study enrollment were not associated with an increase in MVPA. Parents’ perception of their child’s functional health status (CHQ‐PF50) was lower on general health (p < 0.01) and family activity (p < 0.01) domains relative to a population‐based cohort of parents reporting on healthy children. Conclusion: Pediatric cardiac transplantation recipients may be indicated to participate in cardiac rehabilitation to optimize physical activity levels.
Current practices and evaluation of screening solid organ donors for West Nile virus
Authors: Nett R.J. , Kuehnert M.J. , Ison M.G. , Orlowski J.P. , Fischer M. , Staples J.E. 
Published: May 2012

AbstractThe first cases of West Nile virus (WNV) transmitted through solid organ transplantation (SOT) were identified in 2002. Subsequently, 5 additional clusters have been reported to public health officials in the United States. Based upon a limited number of known cases, patients who acquire WNV from infected donor organs might be at higher risk for severe neurologic disease and death, compared with patients infected through mosquito bites. In response, some organ procurement organizations (OPOs) have instituted pre‐transplant screening of organ donors for WNV infection. We evaluated the current practices, concerns, and challenges related to screening organ donors for WNV in the United States by reviewing the relevant medical literature and interviewing key stakeholders. Screening organ donors for WNV is not required by national policy. In 2008, 11 (19%) of 58 OPOs performed WNV screening using nucleic acid amplification testing (NAT). These OPOs differ in their screening strategies, NAT performed, and logistical challenges. Concerns of delays in receiving NAT results before transplant and potential false‐positive results leading to organ wasting are limitations to more widespread screening. Furthermore, it is unknown if WNV screening practices decrease SOT‐related morbidity and mortality, or if screening is cost‐effective. Additional data are needed to assess and improve transplant outcomes related to WNV.
Impact of sunlight on the age of onset of bipolar disorder
Authors: Bauer Michael , Glenn Tasha , Alda Martin , Andreassen Ole A , Ardau Raffaella , Bellivier Frank , Berk Michael , Bjella Thomas D , Bossini Letizia , Del Zompo Maria , Dodd Seetal , Fagiolini Andrea , Frye Mark A , Gonzalez‐Pinto Ana , Henry Chantal , Kapczinski Flávio , Kliwicki Sebastian , König Barbara , Kunz Mauricio , Lafer Beny , Lopez‐Jaramillo Carlos , Manchia Mirko , Marsh Wendy , Martinez‐Cengotitabengoa Mónica , Melle Ingrid , Morken Gunnar , Munoz Rodrigo , Nery Fabiano G , O’Donovan Claire , Pfennig Andrea , Quiroz Danilo , Rasgon Natalie , Reif Andreas , Rybakowski Janusz , Sagduyu Kemal , Simhandl Christian , Torrent Carla , Vieta Eduard , Zetin Mark , Whybrow Peter C 
Published: May 2012

Bauer M, Glenn T, Alda M, Andreassen OA, Ardau R, Bellivier F, Berk M, Bjella TD, Bossini L, Del Zompo M, Dodd S, Fagiolini A, Frye MA, Gonzalez‐Pinto A, Henry C, Kapczinski F, Kliwicki S, König B, Kunz M, Lafer B, Lopez‐Jaramillo C, Manchia M, Marsh W, Martinez‐Cengotitabengoa M, Melle I, Morken G, Munoz R, Nery FG, O’Donovan C, Pfennig A, Quiroz D, Rasgon N, Reif A, Rybakowski J, Sagduyu K, Simhandl C, Torrent C, Vieta E, Zetin M, Whybrow PC. Impact of sunlight on the age of onset of bipolar disorder. Bipolar Disord 2012: 14: 654–663. © 2012 The Authors. Journal compilation © 2012 John Wiley & Sons A/S.Objective:  Although bipolar disorder has high heritability, the onset occurs during several decades of life, suggesting that social and environmental factors may have considerable influence on disease onset. This study examined the association between the age of onset and sunlight at the location of onset.Method:  Data were obtained from 2414 patients with a diagnosis of bipolar I disorder, according to DSM‐IV criteria. Data were collected at 24 sites in 13 countries spanning latitudes 6.3 to 63.4 degrees from the equator, including data from both hemispheres. The age of onset and location of onset were obtained retrospectively, from patient records and/or direct interviews. Solar insolation data, or the amount of electromagnetic energy striking the surface of the earth, were obtained from the NASA Surface Meteorology and Solar Energy (SSE) database for each location of onset.Results:  The larger the maximum monthly increase in solar insolation at the location of onset, the younger the age of onset (coefficient= −4.724, 95% CI: −8.124 to −1.323, p = 0.006), controlling for each country’s median age. The maximum monthly increase in solar insolation occurred in springtime. No relationships were found between the age of onset and latitude, yearly total solar insolation, and the maximum monthly decrease in solar insolation. The largest maximum monthly increases in solar insolation occurred in diverse environments, including Norway, arid areas in California, and Chile.Conclusion:  The large maximum monthly increase in sunlight in springtime may have an important influence on the onset of bipolar disorder.
Validation for root‐related quantitative trait locus effects of wild origin in the cultivated background of barley (Hordeum vulgare L.)
Authors: Ahmad Naz Ali , Ehl Alexandra , Pillen Klaus , Léon Jens 
Published: May 2012

With 4 figures and 2 tablesAbstractExtensive root system plays a major role in plant’s ability to tolerate water deficit conditions. Recently, quantitative trait locus (QTL) effects of wild origin associated with natural variation of root parameters were detected on the distal arm of chromosome 5H using 301 BC2DH lines of a cross between spring barley cultivar ‘Scarlett’ and the wild barley accession ISR42‐8. Here, we report the validation of these QTL effects in the near isogenic background of ‘Scarlett’ by using introgression lines (ILs; S42IL‐126 and S42IL‐176) of the targeted region. S42IL‐126 encompasses a single wild introgression on chromosome 5H, reaching out from 145.57 to 200.12 cM, whereas S42IL‐176 harbours a major introgression on chromosome 5H from 154.37 to 234.98 cM along with three minor introgressions on chromosomes 1H, 2H and 3H. S42IL‐126, S42IL‐176, ‘Scarlett’ and ISR42‐8 were evaluated for the root‐related traits; root dry weight (RDW), root volume (RV), root length and the associated traits; shoot dry weight and change in tiller number during drought stress (ΔTIL). The phenotypic evaluations revealed contrasting root systems in both parents where ISR42‐8 inherited highly extensive fibrous roots with respect to ‘Scarlett’. Both ‘Scarlett’ and S42IL‐126 developed smaller roots and showed no variation in root parameters, indicating that the wild introgression present in S42IL‐126 does not contain QTL alleles for the above‐mentioned root traits. On the contrary, S42IL‐176 revealed remarkable trait increases in RDW, RV and ΔTIL, which are similar to the donor parent ‘ISR42‐8’. The trait increases in S42IL‐176 are presumably due to the presence of exotic alleles at the QTLs QRDW.S42IL‐1, QRV.S42IL‐1 and QΔTIL.S42IL‐1. The comparison of phenotypic data and overlapping introgressions between S42IL‐126 and S42IL‐176 suggests that these QTLs reside on chromosome 5H in the interval between 200.12 and 234.98 cM. On the basis of the magnitude of QRDW.S42IL‐1, QRV.S42IL‐1 and QΔTIL.S42IL‐1, it is likely that these QTL effects are also linked to extra introgressions of S42IL‐176 present on chromosomes 1H where a QTL effect for RDW was also detected previously at the corresponding region of the wild introgression. In future, a follow‐up study with segregating offspring which are derived from S42IL‐176 will help to ultimately quantify and map the identified QTLs. On the basis of our QTL study, S42IL‐176 can be used for positional cloning of the underlying genes as well as to improve the root parameters of cultivated varieties.
Potential to improve oilseed rape and canola breeding in the genomics era
Authors: Snowdon Rod J. , Iniguez Luy Federico L. 
Published: May 2012

With 2 figures and 1 tableAbstractHigh‐throughput genomics technologies today offer unprecedented possibilities for gene discovery, complex trait analysis by genome‐wide association studies, global gene expression analyses, genomic selection and predictive breeding strategies. Dissection of the complex Brassica napus genome using mapping‐by‐sequencing techniques provides a powerful bridge between genetic maps and genome sequences. The completed sequence of the Brassica rapa A genome and the expected forthcoming publication of the C genome (Brassica oleracea) will greatly accelerate the release of public reference sequences for B. napus (genome AC). Dramatically falling DNA costs for targeted or genomic resequencing and the availability of a new, high‐density B. napus single‐nucleotide polymorphism (SNP) array open the way for considerably more efficient mining and exploitation of genetic variation within the primary and secondary gene pools of B. napus. In this review, we outline some of the most significant recent advances in high‐throughput genomics of Brassica crops and their potential impact on germplasm development and breeding of oilseed rape and canola in the coming years and decades.
The Combinatorial Effect of Different Equex STM Paste Concentrations, Cryoprotectants and the Straw‐Freezing Methods on the Post‐Thaw Boar Semen Quality
Authors: Wu T‐W , Cheng F‐P , Chen I‐H , Yang C‐H , Tsai M‐Y , Chang M‐H , Wang J‐H , Wu J‐T 
Published: May 2012

ContentsThis study was to evaluate the combinatorial effect (14 treatments, A–N) of different Equex STM paste concentrations, cryoprotectants and the straw‐freezing method on the post‐thaw boar semen quality. Two ejaculates were collected from each of nine boars (three boars from each of three breeds). Semen was diluted in extenders with different concentrations of Equex STM paste and different cryoprotectants [glycerol or dimethylacetamide (DMA)] before cryopreserving via liquid nitrogen or dry ice. Motility, viability, percentage of spermatozoa with intense acrosomal staining and with normal morphology of post‐thaw sperm were evaluated. The qualities of thawed semen were best preserved in treatment H (extender with 0.5% Equex STM paste and 5% glycerol and freezing by dry ice) and were worst in treatment B (extender with 0% Equex STM paste and 5% DMA and freezing by dry ice). Significant difference (p < 0.05) was present in post‐thawed sperm motility (63% vs 27%), sperm viability (70% vs 33%) and sperm acrosomal integrity rate (68% vs 29%) between treatments H and B. However, sperm proportion with normal morphology showed no significant difference among treatments (66% vs 66%; p > 0.05). Moreover, statistical analysis suggests that no significant difference was present in semen quality among breed or individual donors (p > 0.05). These findings suggest that Equex STM paste improved the cryosurvival efficiency of boar sperm, and the favourable straw‐freezing method changes between glycerol and DMA.