bluuebunny/crossref_metadata_2025_split huggingface dataset:
The performance of ChatGPT in day surgery and pre-anesthesia risk assessment: a case-control study across on 150 simulated patient presentations
Authors: Li Yu , Tingting Cheng , Gu Jiaqiu , He Yibo , He Guangbao , Zou Peipei , Li Shuyun , Xu Hang , Bao Yang , Wang Xuejun 
Published: May 2024

Abstract

Background
Day surgery has developed rapidly in China in recent years, although it still faces the shortage of anesthesiologists to handle pre-anesthesia routine for day surgery. We hypothesized that Chat Generative Pre-trained Transformer (ChatGPT) may assist anesthesiologists in preoperative assessment and answer questions on the patients' concerns. The aim of this study was to examine the ability of ChatGPT in pre-operative risk assessment and its accuracy to answer questions regarding knowledge and management for day surgery anesthesia.
Methods
150 patient profiles were generated to simulate day surgery patient presentations, with complications of varying acuity and severity. Both ChatGPT group and expert group has to evaluate 150 patients for their ASA classification and whether day surgery was recommended. Then ChatGPT was asked to answer 145 questions about day surgery anesthesia that represented the most common issues encountered in clinical practice. The performance of ChatGPT was assessed and graded independently by two experienced anesthesiologists.
Results
A total of 150 patients for assessment were included in the study (74 males [49.5%] and 76 females [50.7%]). There was no difference between ChatGPT group and the expert group for ASA classification and assessment of anesthesia risk in the patients (P > 0.05). When comes to day surgery recommendation, for patients with certain comorbidities (ASA ≥ II), the expert group was inclined to need further examination or treatment, the proportion of conclusions made by ChatGPT was smaller (ChatGPT n (%) vs. expert n (%): day surgery can be performed, 67 (47.9) vs. 31(25.4); need further treatment and evaluation, 56 (37.3) vs. 66 (44.0); day surgery is not recommended, 18 (12.9) vs. 29 (9.3), P < 0.05). We showed that ChatGPT had extensive knowledge related to day surgery anesthesia (94.0% correct), with most of the points (70%) considered comprehensive. The performance was better in the domains of peri-anesthesia concerns, lifestyle, and emotional support.
Conclusions
ChatGPT has certain reference value for ASA classification and assessment of anesthesia risk in patients. ChatGPT can also be trusted to answer questions and concerns related to pre-anesthesia and therefore has the potential to provide important assistance in clinical work.
High-Pressure Phase Transition in 3-D Printed Nanolamellar High-Entropy Alloy: Imaging and Simulation Insights
Authors: Vohra Yogesh , Pope Andrew , Chen Wen , Chen Hangman , Cao Penghui , Manukyan Khachatur , Zhukovskyi Maksym , Yeghishyan Armenuhi 
Published: May 2024

Abstract

We report on the high-resolution imaging and molecular dynamics simulations of a 3D-printed eutectic high-entropy alloy (EHEA) Ni40Co20Fe10Cr10Al18W2 consisting of nanolamellar BCC and FCC phases. The direct lattice imaging of 3D-printed samples shows the Kurdjumov-Sachs (K-S) orientation relation {111} FCC parallel to {110} BCC planes in the dual-phase lamellae. Unlike traditional iron and steels, this alloy shows an irreversible BCC-to-FCC phase transformation under high pressures. The nanolamellar morphology is maintained after pressure cycling to 30 GPa, and nano-diffraction studies show both layers to be in the FCC phase. The chemical compositions of the dual-phase lamellae after pressure recovery remain unchanged, suggesting a diffusion-less BCC-FCC transformation in this EHEA. The lattice imaging of the pressure-recovered sample does not show any specific orientation relation between the two resulting FCC phases, indicating that many grain orientations are produced during the BCC-FCC phase transformation. Molecular dynamics simulations on phase transformation in a nanolamellar BCC/FCC in K-S orientation show that phase transformation from BCC to FCC is completed under high pressures, and the FCC phase is retained on decompression aided by the stable interfaces. Our work elucidates the irreversible phase transformation, providing an understanding of the orientation relationships in 3-D printed EHEA under high pressures.
Choroidal thinning in myopia is associated with axial elongation and severity of myopic maculopathy
Authors: Midorikawa Momoka , Mori Kiwako , Torii Hidemasa , Tomita Yohei , Zhang Yan , Tsubota Kazuo , Kurihara Toshihide , Negishi Kazuno 
Published: May 2024

Abstract

High myopia can lead to pathologic myopia and visual impairment, whereas its causes are unclear. We retrospectively researched high myopia cases from patient records to investigate the association between axial elongation and myopic maculopathy. Sixty-four eyes were examined in patients who visited the department between July 2017 and June 2018, had an axial length of 26 mm or more, underwent fundus photography, and had their axial length measured twice or more. The average axial length was 28.29±1.69 mm (mean±standard deviation). The average age was 58.3 ± 14.4 years old. Myopic maculopathy was categorized as mild (grades 0 and 1) and severe (grades 2, 3, and 4). The severe group had longer axial lengths than the mild group (p<0.05). Moreover, the severe group exhibited thinner choroidal thickness than the mild group (p<0.05). When subjects were grouped by axial elongation over median value within a year, the elongation group showed thinner central choroidal thickness than the non-elongation group (142.1±91.9 vs. 82.9±69.8 ㎛, p<0.05). In conclusion, in patients with high myopia, the severity of maculopathy correlated with choroidal thickness and axial length. Thinner choroidal thickness was associated with axial elongation based on the baseline axial length.
Phytochemical analysis of the extract from berries of Schisandra chinensis Turcz. (Baill.) and its anti-platelet potential in vitro
Authors: Sławińska Natalia , Kontek Bogdan , Żuchowski Jerzy , Moniuszko-Szajwaj Barbara , Białecki Jacek , Zakrzewski Kamil , Bogusz Paulina , Stochmal Anna , Olas Beata 
Published: May 2024

Abstract

Schisandra chinensis Turcz. (Baill.) is a dioecious vine, belonging to the Schisandraceae family. Itsberries show several beneficial activities, including cardioprotective, antioxidant, and anti-inflammatory. We examined the chemical content of the extract from S. chinensis berries, as well as its antiplatelet potential in washed human blood platelets and whole blood in vitro. We assessed effect of the extract on several hemostasis parameters, including thrombus formation in full blood, platelet activation and adhesion, and coagulation times. Moreover, we evaluated the cytotoxicity of the extract against blood platelets based on extracellular lactate dehydrogenase (LDH) activity. The most important constituents of the extract were dibenzocyclooctadiene lignans; schisandrin was the dominant compound. The extract inhibited thrombus formation, agonist-stimulated platelet activation and adhesion, and was not cytotoxic. These results suggest that S. chinensisberries can be used as a safe, natural supplement with anti-platelet properties. However, more studies are needed to determine their mechanisms of action and in vivo efficiency.
The magnitude of preconception care utilization and associated factors among women in Ethiopia: Systematic review and Meta- analysis, 2024
Authors: Abeneh Aysheshim , Getahun Worku Taye , Agmassie Getachew Altaseb , Gelaw Sintayehu Shiferaw , Kassie Tadele 
Published: May 2024

Abstract

BackgroundNowadays globally a woman dies in every two minutes, and a neonate dies even in every 12 seconds, and more than two-thirds of these maternal deaths are preventable. Preconception care is a continuum of maternity care which is one of the proven strategies to reduce not only maternal mortality and morbidity but also neonatal mortality and morbidity by improving women’s health. Therefore, this study aimed to assess the pooled magnitude of preconception care utilization and its associated factors among women in Ethiopia.MethodsSearching of studies done through PubMed, Medline, Embase, Cochrane Library, List of References, and Google Scholar. This systematic review and meta-analysis follow the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) godliness. The quality of studies was assessed by using a Newcastle- Ottawa Scale (NOS) assessment tool adapted for cross-sectional studies. Analysis was performed using a random effect model by using STATA 17 version software. Egger’s weighted regression and I2test were used to evaluate publication bias and heterogeneity respectively.ResultsIn this systematic review and meta-analysis, a total of 6,808 women from 14 primary studies were included. The overall pooled magnitude of preconception care utilization in Ethiopia was 26% (95% CI: 18, 34). Educational status (OR = 2.18, 95%CI 1.54, 2.82), adequate knowledge of women regarding preconception care (OR = 2.69, 95%CI 1.90, 3.48), pre-existing medical illness (OR = 4.79, 95%CI 2.61, 6.06), history of adverse pregnancy outcome (OR = 3.18, 95%CI 2.74, 3.62), and husband /partner support (OR = 3.26, 95%CI 1.55, 4.97) were the identified predictors of utilization of preconception care.ConclusionThe overall magnitude of preconception care utilization among Ethiopian women was significantly low. Educational status of women, knowledge of women regarding Preconception care, history of adverse birth outcome, pre-existing chronic medical illness, and either psychological or financial husband support were the identified predictors of preconception care utilization. Thus, healthcare organizations should work on strategies to improve the utilization of preconception care. In addition to this, advocating for better women's education, awareness creation, and encouraging male involvement is very essential to optimize service utilization. PROSPERO registration: CRD42023492995 registered on 23/12/2023.
Harm avoidance and incompleteness core motivations in obsessive-compulsive disorder: Cross-cultural adaptation and validation of the Persian version of the Obsessive- Compulsive Core Dimensions Questionnaire (OC-CDQ) in clinical and nonclinical samples
Authors: Pourebrahimi Mahjoubeh , Sarafraz Mehdireza , Hadianfard Habib , Mohammadi Nurallah 
Published: May 2024

Abstract

Background The Obsessive-Compulsive Core Dimensions Questionnaire (OC-CDQ) is the first measure created to assess the motivational dimensions of experiential avoidance in individuals with obsessive-compulsive disorder (Harm Avoidance (HA) and Incompleteness (INC)). The OC-CDQ has been translated and validated in several languages, but not in Persian. This study aimed to translate and investigate the factor structure, reliability, and validity of the Persian version of the OC-CDQ in a clinical group with obsessive-compulsive disorder (OCD) and nonclinical group without OCD.
Methods The Persian version of the OC-CDQ was translated and culturally adapted according to international guidelines, including translation, back‑translation, pretesting, and expert committee review. A total of 209 outpatients diagnosed with OCD based on the DSM-V completed the Yale-Brown Obsessive Compulsive Scale (Y-BOCS), Obsessive-Compulsive Core Dimensions Interview (OC-CDI), Persian version of the OC-CDQ, Obsessive Belief Questionnaire (OBQ-44) and Beck's Anxiety Inventory (BAI). Additionally, 209 participants without OCD completed the Persian version of the OC-CDQ. To investigate the test-retest reliability, 60 people (30 people from each group) completed the Persian version of the OC-CDQ again after a two-week interval.
Results Similar to the original version, the confirmatory factor analysis (CFA) indicated a good fit of the two-factor structure. The reliability of the Persian version of the OC-CDQ, as determined by the Cronbach's alpha coefficient, split-half, and retest indicated good reliability (clinical sample: ranging from 0.72 to 0.81, nonclinical sample: ranging from 0.74 to 0.83). Convergent validity was evaluated through the correlation of the OC-CDQ with the Y-BOCS, OC-CDI, and OBQ-44. Divergent validity was evaluated through correlation with BAI. The results supported the validity of the Persian version of the OC-CDQ (p<0.05). The results of hierarchical regression analysis indicated the incremental validity of this scale in predicting the Y-BOCS and BAI compared to the OBQ-44 (p<0.05), and comparing the scores of two groups with and without OCD indicated its discriminant validity (p<0.01).
Conclusion The Persian‑OC-CDQ, developed after the translation and cross‑cultural adaptation process, is a valid tool for evaluating the motivational dimensions of harm avoidance and incompleteness in Iranian individuals with and without OCD.
MEX3A is a new diagnostic, independent prognostic biomarker and a promising therapeutic target in gliomas
Authors: Bufalieri Francesca , Armocida Daniele , Cucinotta Antonino , Familiari Pietro , Magno Laura Di , Serraino Alessandra , Adabbo Gennaro , Severini Ludovica Lospinoso , Frati Alessandro , Canettieri Gianluca , Infante Paola , Santoro Antonio , D’Angelo Luca , Marcotullio Lucia Di 
Published: May 2024

Abstract

Gliomas are the most common malignant brain tumors with a dismal prognosis. Despite the progress in defining molecular features, no therapies targeting the known biomarkers significantly increase the survival rate of glioma patients. Recently, it has been demonstrated that high expression of Muscle Excess 3A (MEX3A) in gliomas correlates with poor overall survival (OS), yet its clinical significance remains largely unknown. In this study, we assessed the correlation between the expression of MEX3A and clinical and molecular characteristics of a cohort of 71 glioma patients, determining its diagnostic and prognostic value and exploring its potential as an innovative therapeutic target. Our analysis revealed that elevated MEX3A expression associates with more severe clinicopathological and molecular features of glioma patients. Furthermore, MEX3A exhibits high diagnostic accuracy and correlates with poor OS and progression free survival. Multivariate COX regression analysis also identified high MEX3A expression as an independent prognostic factor for OS. Notably, MEX3A genetic depletion inhibits primary human glioma cells growth both in vitro and in vivo. Our finding emphasizes the connection between MEX3A expression and clinical and molecular aspects in glioma patients, indicating that MEX3A expression represents a new diagnostic and independent prognostic biomarker, as well as a promising therapeutic target.
Innovative peat-free organic substrate and fertilizer affects nutrient allocation in different organs of pedunculate oak (Quercus robur L.) and European beech (Fagus sylvatica L.) seedlings
Authors: Rotowa Odunayo James , Małek Stanisław , Jasik Michał , Staszel-Szlachta Karolina 
Published: May 2024

Abstract

This study evaluates the effects of novel peat-free organic substrates and a novel liquid fertilizer on the biometric features and macronutrient allocation of Quercus robur and Fagus sylvatica seedlings with the view to compare biomass and nutrient allocation of plant organs in seedlings cultivated on peat substrates against those grown on novel peat-free substrates and fertilizer. The experimental setup involved four substrate variants, including the control (R20, R21, R22 and C). The novel substrates and fertilizer were designed and formulated by the University of Agriculture in Kraków, Poland (UAK). Fertilization used in the state forest nurseries was represented as SR20, SR21, and SR22, while the novel fertilizer of UAK was represented as UR20, UR21, and UR22; meanwhile, SC and UC represented the control substrates (peat) in both cases, respectively. The experiment was laid in a 2x2x4 experimental design using five seedlings per treatment. Seedlings were assessed for height, collar diameter, and roots, shoots, and leaves biomass. The allocation patterns highlighted the variability of nutrient allocation within the plants, with more nutrients allocated to the root system. Interestingly, treatment UR22 yielded the highest mean root values, root biomass, and virtually all macroelement allocation. Overall, peat-free substrates with novel liquid fertilizer demonstrated competitive traits supporting seedling growth, with significant differences observed in the allocation of nutrients like nitrogen, phosphorus, and potassium. Based on the study results, peat-free substrates with the recommended dosage of novel fertilizer improved seedlings' quality, enhancing the growth and nutrient allocation in different organs of tree seedlings.
Intramyocardial and Intra-atrial courses in the Right Coronary Artery: Prevalence and characteristics
Authors: Akturk Yeliz , Kavak Rasime Pelin , Akin Nimet , Hekimoglu Omer Koray 
Published: May 2024

Abstract

Purpose
We aimed to determine the prevalence and radiological characteristics of myocardial bridging (MB) and intra-atrial course anomaly (IARCA), which are rare course variations of the right coronary artery (RCA), in the adult patient population.
Methods
Radiological images of cases over the age of 18 who underwent coronary CT angiography (CTA) examination in our clinic were scanned from the archives retrospectively, and cases with MB of the RCA and IARCA detection were included in the study. The number, age and gender distribution of the cases, whether there were any other accompanying vascular anomalies, whether there was atherosclerosis in the coronary arteries (calculation of Agatston total calcium score, calculation of atherosclerotic stenosis as a percentage, if any) were evaluated.
Results
The prevalence of MB in the RCA was 2.06%, and the prevalence of IARCA was 0.44%. In one case, both anomalies were detected together. The average MB segment length in RCA was 21.9mm, and the average IARCA segment length was 37.9mm. There was no atherosclerotic disease in the RCA segment where anomaly was detected.
Conclusion
Recognition of rare course anomalies of RCA before treatment procedures such as ablation and surgery is important to prevent complications that may have potentially fatal consequences.
Wolbachia infection in natural mosquito populations from Argentina
Authors: Chuchuy Ailen , Rodriguero Marcela S. , Alonso Ana C. , Stein Marina , Micieli María V. 
Published: May 2024

Abstract

The increasing spread of mosquito vectors has made mosquito-borne arboviral diseases a global threat to public health, leading to the urgent need for effective control of such populations. Methods based in the intracellular bacterium Wolbachia Hertig, 1936 are considered environmentally friendly, human-safe, and potentially cost-effective biocontrol strategies to control arboviral diseases. In order to minimize undesirable side effects, it is relevant to understand if Wolbachia ranges in the area and the diversity associated to native infections before implementation. With this purpose, we investigated Wolbachia infection status, diversity and prevalence in populations of Aedes albifasciatus (Macquart, 1838), Aedes fluviatilis (Lutz, 1904), and hybrids of the Culex pipiens (Linnaeus, 1758) complex from Argentina. Additionally, we preliminarily explored the influence of environmental temperature on the Wolbachia prevalence in Ae. fluviatilis. Aedes albifasciatus and Cx. pipiens complex samples were collected in the province of Buenos Aires, and Ae. fluviatilis in the province of Misiones. Aedes albifasciatus was uninfected and infections with strains wFlu and wPip were revealed in Ae. fluviatilis and hybrids of the Cx. pipiens complex, respectively. All strains were fixed or close to fixation and clustered within supergroup B. No effects of environmental temperature on Wolbachia prevalence of Ae. fluviatilis larvae were revealed, at least with the current design. These results provide valuable information on Wolbachia strains found in natural populations of mosquitoes from Argentina that might be used in heterologous infections in the future or must have taken into account when designing control strategies based on Wolbachia infection.
An optimized Q algorithm based on Slot prediction
Authors: Wen Jiahao , Luo Jiacheng , Yang Jian 
Published: May 2024

Abstract

High throughput is crucial for Electronic Toll Collection(ETC) systems to effectively reduce traffic congestion. However, traditional algorithms face challenges such as slot waste and slow adjustments in frame length. To tackle these issues, a Slot Prediction Q algorithm(SPQ) has been introduced, which combines the Vogt-Ⅱ Prediction algorithm and slot grouping concept to improve the initial Q-value by predicting the first frame. This algorithm can quickly predict the number of tags to be identified based on slot utilization, speeding up the Q-value adjustment process when slot utilization is low. Additionally, the Markov decision chain is used to determine the optimal relationship between the number of slot groupings x and Q-value. The Whale Optimization Algorithm(WOA) is employed to optimize the relationship between the learning rate C and Q-value in the traditional Q algorithm. Simulation results show that SPQ significantly reduces the total number of slots used during the reading process, thereby enhancing the ETC throughput.
Real-world experience with direct-acting antiviral therapy in HCV-infected patients with cirrhosis and esophageal varices
Authors: Brzdęk Michał , Zarębska-Michaluk Dorota , Kukla Michał , Janocha-Litwin Justyna , Dybowska Dorota , Janczewska Ewa , Lorenc Beata , Berak Hanna , Mazur Włodzimierz , Tudrujek-Zdunek Magdalena , Klapaczyński Jakub , Piekarska Anna , Sitko Marek , Laurans Łukasz , Parfieniuk-Kowerda Anna , Flisiak Robert 
Published: May 2024

Abstract

Background
Hepatitis C virus (HCV) infection affects 58 million people worldwide with around 290,000 deaths annually, mainly due to complications such as cirrhosis and hepatocellular carcinoma (HCC). Portal hypertension (PH) caused by cirrhosis leads to severe consequences, including esophageal varices (EV). To evaluate the effectiveness and safety of DAA treatment in patients with and without EV.
Methods
This retrospective analysis involved consecutive HCV-infected adults undergoing DAA therapy at 22 Polish hepatology centers from July 1, 2015, to December 31, 2022. Patients with cirrhosis were categorized based on presence of EV diagnosed by gastroscopy. Treatment effectiveness was measured by sustained virologic response (SVR), with safety outcomes monitored during and for 12 weeks post-treatment.
Results
The population of 3393 HCV-infected patients with cirrhosis was divided into groups with (A, n = 976) and without (B, n = 2417) EV. Group A showed a significantly higher prevalence of comorbidities and concomitant medications. Genotype (GT)1b infections predominated in both groups, and GT3 infections were more common in the EV group. Group A exhibited more severe liver disease, and higher rates of decompensation, HCC, and HBV co-infection. SVR was significantly higher in group B (91.5% vs. 96.3%, p<0.0001). Male gender, GT3, EV presence, and Child-Pugh grade B were identified as independent negative SVR predictors. Group A had a worse safety profile, with notably higher adverse event incidence and mortality.
Conclusions
DAA therapies are highly effective and well tolerated in patients with cirrhosis, but EV presence predicts poorer virologic responses.