bluuebunny/crossref_metadata_2025_split huggingface dataset:
Specialized compounds of four Cameroonian spices: Isolation, characterization, and in silico evaluation as prospective SARS-CoV-2 inhibitors
Authors: Happi Gervais Mouthé , Sikam Klev Gaïtan , Ibrahim Mahmoud A. A. , Dzouemo Liliane Clotilde , Kemayou Guy-Paulin M. , Keuteu Praid Likane , Sidhom Peter A. , Sayed Shaban R. M. , Hegazy Mohamed-Elamir F. , Wansi Jean Duplex 
Published: June 2024

Abstract
Since the emergency of coronavirus disease 2019, no specific drug has been developed within the fighting program against its spread. In Cameroon, it has been reported that the dish “yellow soup” can significantly curb the progress of the disease, while no chemical investigations have been done so far to support that conclusion. Chemical investigations of four selected spices of that dish led to the isolation of a total of 44 distinct pure compounds, which were identified using spectroscopic data. Furthermore, the docking scores of the isolated compounds were inspected by AutoDock4.2.6 software toward SARS-CoV-2 multi-targets involving main protease (Mpro), helicase, papain-like protease (PLpro), and human angiotensin‐converting enzyme 2 (ACE2). The most potent isolated compounds underwent molecular dynamics (MD) simulations over 100 ns. Stigmasterol demonstrated outstanding potency toward Mpro and PLpro with ΔG
binding values of −35.6 and −36.6 kcal/mol, respectively, compared to nirmatrelvir. Nevertheless, 3β-taraxeryl acetate revealed good binding affinity against helicase and lupeol unveiled superior binding energy toward ACE2 compared to nirmatrelvir. Post-MD analyses manifested great steadiness of the isolated compounds within the binding pockets of SARS-CoV-2 targets throughout 100 ns MD simulations. Stigmasterol, 3β-taraxeryl acetate, and lupeol are recommended for further in vivo/in vitro tests toward SARS-CoV-2 multi-targets.
Accumulation mechanism of multi-type unconventional oil and gas reservoirs in Northern China: Taking Hari Sag of the Yin’e Basin as an example
Authors: Ding Chao , Chen Zhijun , Guo Lan , Guo Shun , Su Xunqing , Bai Xiaoyin 
Published: June 2024

Abstract
Many multi-types of unconventional oil and gas reservoirs have been found in some faulted basins in northern China, showing good exploration potential. However, the hydrocarbon accumulation mechanism in these areas is still unclear, which limits the understanding of the distribution of oil and gas. In this study, we took Hari Sag in Yin’e Basin as an example, conducted a systematic analysis on various types unconventional oil and gas reservoirs, and revealed its characteristics and accumulation mechanisms. The study showed that there were many types of unconventional oil and gas reservoirs in Hari Sag, such as biogas reservoirs, shale gas reservoirs, shale oil reservoirs, tight sandstone oil reservoirs, tight sandstone gas reservoirs, and volcanic gas reservoirs. These reservoirs generally had characteristics of “near/within source rocks accumulation,” “coexistence of oil reservoirs and gas reservoirs,” “shallow oil and deep gas,” and so on. Research on the mechanism of hydrocarbon accumulation showed that: the lack of effective hydrocarbon migration pathway was the main reason for “near/within source rocks accumulation” of oil and gas reservoirs; the differences in the thermal evolution degree of the main source rocks at different structural positions in the sag made the distribution characteristics of hydrocarbon as “coexistence of oil reservoirs and gas reservoirs” and “shallow oil and deep gas”; and the joint development of multi-type effective unconventional reservoirs created the situation of “coexistence of multi-type unconventional oil and gas reservoirs.” It is predicted that six types of unconventional oil and gas reservoirs have a cumulative area of 381 km2, indicating that the Hari Sag has great potential for unconventional oil and gas exploration. The research results can not only guide the unconventional oil and gas exploration in Hari Sag but also provide a theoretical basis for exploration research in similar blocks.
Analyzing recent deformation in Wadi Hagul, Eastern Desert, Egypt, via advanced remote sensing and geodetic data processing
Authors: Etman Mahmoud S. , Mohamed Sayed A. , Saleh Salah , Mohamed Abdel-Monem S. , Fergawy Karrar O. 
Published: June 2024

Abstract
The Wadi Hagul region in the eastern desert of Egypt is facing seismic hazards and increased human activity. This study uses remote sensing and geodetic methods to monitor and analyze recent deformation in the area. Interferometric Synthetic Aperture Radar (InSAR) data from the Sentinel-1A satellite and Global Navigation Satellite System (GNSS) data were combined to track surface movements and deformations accurately. The study analyzed InSAR data from February 4, 2020, to February 07, 2024, and GNSS data from the Wadi Hagul geodetic network established in July 2022 and monitored until January 2024. Despite the relatively short GNSS monitoring period, it provided valuable insights into recent deformation trends. By integrating data from ten GNSS stations, including International Geodetic stations (IGS), and InSAR scenes from the Sentinel-1A mission, the study estimated recent ground deformation in the region. The main objectives were to analyze recent crustal movements by identifying spatial and temporal patterns of deformation and assess implications for geological processes. In Key Findings, horizontal movement fluctuates between 0.5 and 2.5 ± 0.1 mm annually across the geodetic network. The estimated velocity of the area was 1.5–2 ± 0.5 mm per year. Integrating GNSS and InSAR data helped calculate movement rates along fault lines and create a fault map. In conclusion, the results suggest that while current deformation rates are moderate, they could increase significantly due to human activity, leading to higher seismic activity and potential earthquakes. Limiting human activity in the region is advisable to prevent negative impacts on nearby populated areas.
Between Virtuous Trust and Distrust: A Model of Political Ideologies in Times of Challenged Political Parties
Authors: Teymouri Niknam Arman , Hemming Pedersen Leif 
Published: June 2024

Abstract
The analytical model of political ideologies offered in this article describes the connection between rising levels of distrust towards societal institutions in modern democracies and how such developments has challenged traditional and long-standing political parties in the Western world, such as the Danish political party Radikale Venstre [the Danish Social-Liberal Party]. Through use of a tripartite model of trust developed by Arman Teymouri Niknam during his interpretation of Mary Wollstonecraft’s attitudes towards trust brought together with different aspects of Axel Honneth’s social-philosophical framework, Teymouri Niknam and Leif Hemming Pedersen show how distrust may be able to act as a progressive tool in the creation of a more just, diverse and equal future and also how a virtuous and healthy form of democracy is an ideal that can be challenging to realise in practice. Teymouri Niknam and Hemming Pedersen are thus able to point to the ways in which a healthy democracy needs a balance of virtuous trust and distrust in order to achieve a good amount of both stability and progress, thus pointing to a difficult balancing act that many traditional political parties find themselves struggling with especially at this point in time in many contemporary democracies.
Sub-Lethal Responses of Delta Smelt to Contaminants Under Different Flow Conditions
Authors:   University of California, Davis, Stillway Marie , Hammock Bruce ,   University of California, Davis, Acuńa Shawn ,   Metropolitan Water District of Southern California, McCormick Amanda ,   University of California–Davis, Hung Tien-Chieh ,   University of California–Davis, Schultz Andrew ,   US Geological Survey, Young Thomas ,   University of California, Davis, Teh Swee Joo ,   University of California, Davis
Published: June 2024

The Delta Smelt is a largely zooplank­tivorous, endangered fish endemic to the San Francisco Estuary (the estuary). High flows increase the availability of fresh and brackish water habitat for Delta Smelt, but also may mobilize contaminants, potentially increasing toxicological stress. Here, we examine the association between contaminants and Delta Smelt health across contrasting water year types and flow-related management actions. Our study spanned the fall season of three years: 1 dry year (2018) bracketed by 2 wet years (2017 and 2019) and coincided with several management actions meant to benefit Delta Smelt. We collected field water from six sites in the estuary that encompass the freshwater and low-salinity habitat of Delta Smelt and analyzed the water for contaminant concentrations. After a 96-hour exposure to the field water, we assessed cultured Delta Smelt survival and the histopathological condition of the gill and liver. Insecticides, particularly fipronil metabolites, were the most prevalent contaminants detected in 2017 and 2018, and a variety of contaminants associated with the rice harvest were detected in 2019. No acute toxicity was observed during any exposure, but we observed negative effects in the livers of Delta Smelt exposed to agricultural water from the Toe Drain and Cache Slough during a 2019 pulse flow action, which coincided with elevated detections and concentrations of organic pesticides. Other noteworthy sub-lethal effects, likely occurring in response to contaminant mixtures, included severe gill lesions in Delta Smelt exposed to Decker Island water in 2019. In the drier year of 2018, lesions were generally mild or absent. Thus, the trade-offs between increased habitat availability and contaminant loading may provide one explanation for why Delta Smelt abundance does not consistently respond positively to outflow.
First record of Coleophora gazella Toll, 1952 in Central Europe with notes on its biology
Authors: Takács Attila , Szabóky Csaba , Bozsó Miklós , Lendvai Gábor 
Published: June 2024

AbstractDuring the past years, we found a new Coleophora taxon in Hungary that proved to be unknown for the fauna of the country. We identified the unknown specimens using combined information from morphological examination including the female genitalia and genetic analyses. We sequenced the Cytochrome Oxidase “COI” gene of the mitochondrial DNA, and used the resultant base-pair sequence for species identification, using the BOLD platform, and for preparing a phylogenetic tree with the most closely related taxa involved. Our results show that larval and adult morphology, genitalia structure, and the sequence of the COI region of the unknown specimens are most similar to those of Coleophora gazella Toll, 1952. The habitats of the species in Hungary are strongly isolated from the nearest population in Turkey (Anatolia). We also studied habitat characteristics and life history of the species, which are briefly presented in this paper. The article contains four figures and two tables.
Awareness among undergraduates about State Dental Council and Medico - legal issues - Stratified cluster random sampling survey
Authors: Rani Anusha , Sharma Dixitha 
Published: June 2024

To assess the level of awareness on State Dental Council and Medico - Legal issues among Undergraduate students.This survey was performed by online distribution of questionnaires in few Dental colleges for final years and internship students In Andhra Pradesh state. The questionnaire consisted of random questions based on Functional, structural aspects of State Dental Council and some prevention-based questions on Medico-Legal issues. The answers were either multiple choice or closed end (yes/no) and were designated with one point for every right answer chooses. A total of 625 respondents completed the questionnaire out of which 350 being intern students and 275 being final year students. Overall, awareness was medium when compared based on level of awareness, year of study and gender variation.The level of awareness is medium among the respondents. However, the knowledge is comparatively high among intern students than final years students. Based on gender, slight variation is observed; females had more awareness compared to males.
Re-intervention in restorative dentistry: Knowledge and attitudes of senegalese dentists
Authors: Diop Elhadji Cyre , Diene Mor Nguirane , Niang Seydina Ousmane , Faye Babacar 
Published: June 2024

Replacing or repairing a defective restoration has become a daily practice in dentistry. It is therefore necessary to know how to evaluate a restoration to decide whether or not to re-intervene and then to choose whether to replace, repair, or refrain from doing so by setting up a monitoring system. The best-known evaluation criteria accepted by the scientific community are the modified Ryge / USPHS criteria and the FDI criteria. In Senegal, no such study has been carried out, and it was with this in mind that our study was carried out, involving 158 dental surgeons. The results showed a predominance of men (70.89%). The average age was relatively young at 37. The study confirmed that re-intervention is common practice among the dentists surveyed: the majority (77.72%) had done a re-intervention less than a week before the survey. The most common reason encountered by dentists for their last re-intervention was fracture of the tooth or restorative material with a rate of 36.71%, then we have caries recurrence and advanced decay and wear with the same rate of 17.09%, followed by pain or hypersensitivity with a rate of 16.46%. After diagnosis, 73% replaced the restoration deemed defective, versus 22% who chose to repair the restoration. Clinical evaluation criteria were used by only 12.66% of the sample. The majority, 74.05% of practitioners, take into account the benefit/risk/cost ratio. The results of this study show the limits of dental surgeons' knowledge in re-intervention, as well as the lack of codification of parameters related to this practice. It is therefore necessary to develop training programs and teaching units for both initial and continuing training.
Effectiveness of aromatherapy in reduction of dental anxiety in pediatric dental patients: A systematic review
Authors: Sachdev Sanpreet Singh , Padawe Dimple , Wankhade Ajinkya , Takate Vilas , Dighe Kishor , Agrawal Arushi 
Published: June 2024

In recent years, various researchers have attempted to utilize Aromatherapy for allaying dental anxiety in pediatric patients. The present systematic review aims to comprehend the efficacy of aromatherapy in reducing dental anxiety in pediatric patients, exploring different aromatherapy agents, dispersion methods, and their anxiety-relieving capacities. A systematic search was performed in the following databases: MEDLINE (Ovid), Pubmed, Pubmed Central, Web of Science Citation Index Expanded (SCIEXPANDED), and Google Scholar using the key terms “Aromatherapy” AND “Pediatric” OR “Children” AND “Dental Anxiety” OR “Fear” to identify articles published in the English language without any restriction for the time of publication. A total of nine randomized controlled trials were identified that assessed various essential oils such as lavender, orange, and lemongrass for aromatherapy in pediatric patients during dental treatment. Most of these studies employed aromatherapy using a diffuser during non-pain-promoting dental treatments in children of 6 to 9 years of age. Aromatherapy is an effective non-pharmacological and non-invasive modality for reducing dental anxiety in pediatric patients which is free of adverse effects. However, there's a need for standardized methods of dispersion and clearer guidelines for oil posology
Institutionalization of Sports for All in Iranian Families
Authors: Kargar Abolfazl , Nazari Rasool , Salimi Mehdi 
Published: June 2024

Background: The institutionalization of sports in families plays a significant role in promoting the health of society. This study is aimed to extract effective background factors in institutionalizing sports in Iranian families.
Methods: The present research follows an interpretive paradigm, inductive logic, and qualitative approach. Besides meta-synthesis approach and interviews were conducted. The research population of the present study included 166 national and international articles presented over the last twelve-year period. After screening the articles, 15 studies were finally selected which met the necessary criteria and were analyzed using the content analysis technique. In the next step, an interview was conducted with 23 experts in "public sports" in a targeted manner using the snowball and theoretical saturation techniques, and finally, the codes of the first and second stages were combined.
Results: Meta-synthesis results led to the identification of 36 indices, the overlap of the codes was compared, and the results showed a reliability of 0.92 After the interview was conducted, 41 indices were identified. The comparison of the results in two time periods showed a reliability of 0.89. Finally, by latent content analysis, summarizing, overlapping, and merging the codes of the previous two steps, 47 influential indices affecting the institutionalization of sports in Iranian families were extracted.
Conclusion: Based on the results of our research it can be concluded that by recognizing, planning, and creating mechanisms for the operationalization of the discovered factors, the process of institutionalizing physical activity in Iranian families will be facilitated.
African swine fever: analysing its epidemiology, pathogenesis and control strategies: a review
Authors: Ranganatha S. , Rathnamma D. , Isloor S. , Hiremath J. , Chandranaik B.M. , Shivashankar B.P. , Shyamsundar K.A. , Rashmi L. , Patil S.S. 
Published: June 2024

African Swine Fever Virus (ASFV) poses a significant threat to global swine populations, with devastating economic and agricultural implications. This review article provides a comprehensive examination of various facets of ASFV, encompassing its structure, entry mechanism, transmission dynamics, clinical signs, pathogenesis, diagnosis and control strategies. The complex virion architecture, including the multilayered core and distinctive outer envelope, is explored, shedding light on key elements influencing the virus’s stability and infectivity. The intricate mechanisms governing ASFV entry into host cells are discussed, emphasizing the interplay between viral proteins and cellular receptors. Insight into the virus-host interaction provides a foundation for understanding the initial stages of infection, influencing subsequent pathogenesis. Transmission dynamics, a critical aspect of ASFV epidemiology, are examined, encompassing both direct and indirect modes of spread. Factors influencing the persistence of ASFV in diverse environments and the role of vectors in disease dissemination are explored to elucidate the complex transmission pathways. Clinical signs and pathogenesis of ASFV infection are thoroughly reviewed, outlining the diverse manifestations in swine species. The immunopathological responses and host factors influencing disease severity are discussed, enhancing our understanding of ASFV pathobiology. A comprehensive understanding of diagnostic tools is pivotal for timely and accurate disease detection, enabling swift intervention measures. In conclusion, this review provides a nuanced and integrative overview of ASFV, offering valuable insights for researchers, veterinarians and policymakers engaged in combatting this significant threat to the swine industry.
Pangenomic analysis identifies correlations between Akkermansia species and subspecies and human health outcomes
Authors: Mueller Katherine D. , Panzetta M. Emilia , Davey Lauren , McCann Jessica R. , Rawls John F. , Flores Gilberto E. , Valdivia Raphael H. 
Published: June 2024

Aim: Akkermansia are common members of the human gastrointestinal microbiota. The prevalence of these mucophilic bacteria, especially Akkermansia muciniphila (A. muciniphila ), correlates with immunological and metabolic health. The genus Akkermansia in humans includes species with significantly larger genomes than A. muciniphila , leading us to postulate that this added genetic content may influence how they impact human metabolic and immunological health.
Methods: We conducted a pangenomic analysis of 234 Akkermansia complete or near-complete genomes. We also used high-resolution species and subspecies assignments to reanalyze publicly available metagenomic datasets to determine if there are relationships between Akkermansia species and A. muciniphila clades with various disease outcomes.
Results: Analysis of genome-wide average nucleotide identity, 16S rRNA gene identity, conservation of core Akkermansia genes, and analysis of the fatty acid composition of representative isolates support the partitioning of the genus Akkermansia into several species. In addition, A. muciniphila sensu stricto , the most prevalent Akkermansia species in humans, should be subdivided into two subspecies. For a pediatric cohort, we observed species-specific correlations between Akkermansia abundance with baseline obesity or after various interventions. For inflammatory bowel disease cohorts, we identified a decreased abundance of Akkermansia in patients with ulcerative colitis or Crohn’s disease, which was species and subspecies-dependent. In patients undergoing immune checkpoint inhibitor therapies for non-small cell lung carcinoma, we observed a significant association between one A. muciniphila subspecies and survival outcomes.
Conclusion: Our findings suggest that the prevalence of specific Akkermansia species and/or subspecies can be crucial in evaluating their association with human health, particularly in different disease contexts, and is an important consideration for their use as probiotics.
Compilation of Apatite Fission-Track Data from the Northeast Atlantic Realm: A Jigsaw Puzzle with Missing Pieces
Authors: Jess Scott , Gröger Heike , Hendriks Bart , Peace Alexander , Schiffer Christian 
Published: June 2024

Abstract
The northeast (NE) Atlantic is one of the best-studied geological regions in the world, incorporating a wide array of geological phenomena including extensional tectonism, passive margin development, orogenesis, and breakup-related volcanism. Apatite fission-track (AFT) thermochronology has been an important tool in studying the onshore evolution of the NE Atlantic for several decades. Unfortunately, large regional-scale studies are rare, making it difficult to study geological processes across the whole region. In this work, a compilation of published AFT data is presented from across Fennoscandia, the British Isles, East Greenland, and Svalbard, with the goal of providing an accessible overview of the data and how this vast body of work has improved our understanding of the region’s evolution. Alongside a review of previous literature, interpolated maps of fission track age and mean track length (MTL) highlight regional trends in the data that may result from major first-order processes and areas of low sample density that should be targeted for future study. Additionally, in the absence of metadata required for thermal history modeling, apparent exhumation rate estimates are calculated from available elevation profiles and the timing of major exhumation events inferred from “boomerang plots” of fission track ages against MTL values. Across Fennoscandia, data suggests that the opening of the NE Atlantic and exhumation of the margin have clearly played a major role in the thermal history of the upper crust. The remaining areas of Britain, Ireland, East Greenland, and Svalbard all present more complex trends consistent with a combination of the NE Atlantic’s opening and the interplay between specific bedrock geology of sampling sites and localized geological processes. Areas of low sample density include southern Britain, NE Britain, southeast Greenland, southern Svalbard, and Eastern Fennoscandia, each of which provides the natural laboratory required to answer many unresolved questions.