bluuebunny/crossref_metadata_2025_split huggingface dataset:
Behavior analysis of juvenile steelhead trout under blue and red light color conditions based on multiple object tracking
Authors: Li Ziyu , Chen Xueweijie , Huang Jinze , An Dong , Zhou Yangen 
Published: May 2024

IntroductionThe lighting environment significantly influences fish behavior. This study explores the impact of diverse lighting conditions on the behavior of steelhead trout (Oncorhynchus mykiss) to illuminate the mechanisms underlying their behavioral responses.MethodsThis experiment was set up with six treatments at a constant light intensity of 150 lx: 12h white light + 12h dark (12 W), 12h blue light + 12h dark (12B), 12h red light + 12h dark (12 R), 1.5h blue light + 9h red light + 1.5h blue light + 12h dark (3B9R), 3h blue light + 6h red light + 3h blue light + 12h dark (6B6R), total 12h of blue and red light + 12h dark (T12BR). A multiple object tracking method, YOLOv5 with SORT, was employed to capture the movement trajectory of each fish, quantifying three motion metrics: swimming velocity, swimming angular velocity, and generalized intersection over union.ResultsThe results revealed that fish exposed to 12R light environment showed significantly higher activity levels than other groups. The mixed light environments (3B9R, 6B6R) formed significant differences in behavioral metrics with 12R earlier than pure light environments (12B, 12W, T12BR), indicating sudden light color changes should be avoided. Fish in the 3B9R environment exhibited the lowest activity level but highest growth performance, with the highest specific growth rate of 1.91±0.12 d-1, a value significantly surpassing the lowest recorded rate, supported by a p-value of 0.0054, indicating it is suitable for steelhead trout cultivation.DiscussBehavioral significant differences were observed as early as week eight, much earlier than physiological differences, which became apparent by week 16. Overall, this paper employs computer vision methods to study the impact of different light colors on fish behavior, found that 3B9R is the optimal lighting condition tested and sudden light color changes should be avoided, offering a new perspective on light conditions and behavior in steelhead trout cultivation.
T-shaped pars plana scleral incision to remove large intraocular foreign body
Authors: Toro Mario Damiano , Nowomiejska Katarzyna , Concilio Marina , Motta Lorenzo , Rekas Krzysztof Marek , Costagliola Ciro , Avitabile Teresio , Castellino Niccolò , Caputo Georges , Choragiewicz Tomasz , Rejdak Robert 
Published: May 2024

AimTo investigate the efficacy and safety profile of T-shaped pars plana scleral incision technique in removing large intraocular foreign bodies, during 23-gauge pars plana vitrectomy.MethodsRetrospective interventional case series that included patients diagnosed with a large intraocular foreign body (IOFB). Possible postoperative complications were recorded 24 h, 1 month, 3 and 6 months postoperatively.ResultsThirty eyes of 30 patients (48 ± 5 years old) were enrolled. All IOFBs were successfully removed: mean diameters of 7.8 ± 2.0 mm and 2.6 ± 0.3 mm. Silicone oil and sulfur hexafluoride were used in 27 and 3 eyes, respectively. Lensectomy was performed in 27 eyes. Intraocular lens was implanted at first attempt in 12 eyes; during a second operation in 12 eyes and 6 eyes remained aphakic. At any follow-up, no signs of postoperative complications were observed. Secondary retinal detachment occurred in 12 eyes. Mean preoperative corrected distance visual acuity was 0.04, on the Snellen scale; it increased to 0.07, at last follow-up. Mean intraocular pressure was 17.97 mmHg. All eyes were preserved.ConclusionT-shaped scleral incision could be an effective, safe and easy-to-perform standard procedure to remove large IOFBs during pars plana vitrectomy, without increasing the risk of surgical complications and additional damage to the ocular tissues.
A machine learning approach to evaluate the impact of virtual balance/cognitive training on fall risk in older women
Authors: Sokołowska Beata , Świderski Wiktor , Smolis-Bąk Edyta , Sokołowska Ewa , Sadura-Sieklucka Teresa 
Published: May 2024

IntroductionNovel technologies based on virtual reality (VR) are creating attractive virtual environments with high ecological value, used both in basic/clinical neuroscience and modern medical practice. The study aimed to evaluate the effects of VR-based training in an elderly population.Materials and methodsThe study included 36 women over the age of 60, who were randomly divided into two groups subjected to balance-strength and balance-cognitive training. The research applied both conventional clinical tests, such as (a) the Timed Up and Go test, (b) the five-times sit-to-stand test, and (c) the posturographic exam with the Romberg test with eyes open and closed. Training in both groups was conducted for 10 sessions and embraced exercises on a bicycle ergometer and exercises using non-immersive VR created by the ActivLife platform. Machine learning methods with a k-nearest neighbors classifier, which are very effective and popular, were proposed to statistically evaluate the differences in training effects in the two groups.Results and conclusionThe study showed that training using VR brought beneficial improvement in clinical tests and changes in the pattern of posturographic trajectories were observed. An important finding of the research was a statistically significant reduction in the risk of falls in the study population. The use of virtual environments in exercise/training has great potential in promoting healthy aging and preventing balance loss and falls among seniors.
Micronutrient status 2 years after bariatric surgery: a prospective nutritional assessment
Authors: Côté Marianne , Pelletier Laurence , Nadeau Mélanie , Bouvet-Bouchard Léonie , Julien François , Michaud Andréanne , Biertho Laurent , Tchernof André 
Published: May 2024

BackgroundAmong commonly performed bariatric surgeries, biliopancreatic diversion with duodenal switch (BPD-DS) provides greater weight loss than Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG), with sustained metabolic improvements. However, the risk of long-term nutritional deficiencies due to the hypoabsorptive component of BPD-DS hinders its widespread use.ObjectiveThe aim of the study was to examine nutritional status over 2 years after BPD-DS, RYGB or SG.MethodsPatients were recruited in the REMISSION trial (NCT02390973), a single-center, prospective study. Out of 215 patients, 73, 48 and 94, respectively, underwent BPD-DS, RYGB or SG. Weight loss, micronutrient serum levels (including iron, calcium, parathormone, vitamins A, B12 and D), and nutritional supplementation were assessed over 2 years. Patients were supplemented according to the type of surgery and individual micronutrient level evolution.ResultsAt baseline, BPD-DS patients were younger than SG patients (p = 0.0051) and RYGB patients had lower body mass index (p &lt; 0.001). Groups had similar micronutrient levels before surgery, with vitamin D insufficiency as the most prevalent nutritional problem (SG: 38.3%, RYGB: 39.9%, BPD-DS: 54.8%, p = 0.08). BPD-DS patients showed lower levels of iron, calcium and vitamin A than SG patients at 24 months. Groups had similar levels of vitamin D at 24 months. Prevalence of vitamin D, calcium, iron, vitamin A and vitamin B12 deficiency was similar among groups at 24 months. Rates of vitamin D insufficiency and iron deficiency were lower at 24 months than at baseline. Micronutrient intake was consistent with recommendations in groups post-surgery, but most BPD-DS patients took vitamin A and vitamin D supplement doses above initial recommendations.ConclusionWith appropriate medical and nutritional management, all surgeries led to similar rates of vitamin D, calcium, iron, vitamin A and vitamin B12 deficiencies at 24 months. However, initial vitamin A and vitamin D supplementation recommendations for BPD-DS patients should be revised upwards.
Efficacy and safety of anlotinib in patients with desmoid fibromatosis: a retrospective analysis
Authors: Xie Mengzhang , Huang Qi , Gong Taojun , Wang Yitian , Li Zhuangzhuang , Lu Minxun , Luo Yi , Min Li , Zhou Yong , Tu Chongqi 
Published: May 2024

IntroductionDesmoid fibromatosis is an aggressive fibroblastic neoplasm with a high propensity for local recurrence. Targeted therapy for Desmoid fibromatosis represents a novel avenue in systemic treatment. Anlotinib, a novel multitargeted angiogenesis inhibitor, represents a novel approach for targeted therapy. Therefore, this study aims to assess the efficacy and safety of anlotinib in patients with Desmoid fibromatosis.MethodsWe retrospectively gathered the clinical medical records of Desmoid fibromatosis patients who underwent anlotinib treatment between June 2019 and November 2023 at our center. Anlotinib was initiated at a daily dose of 12 mg and adjusted based on drug-related toxicity. Tumor response was evaluated using the Response Evaluation Criteria in Solid Tumors 1.1 criteria. Progression-free survival served as the primary endpoint and was analyzed utilizing the Kaplan–Meier method.ResultsIn total, sixty-six consecutive patients were enrolled. No patients achieved a complete response; however, fourteen patients (21.21%) exhibited a partial response, while forty-six patients (70%) experienced disease stability. Progressive disease was observed in 6 patients (9.10%), and the progression-free survival rates at 12 and 36months were 89.71% and 82.81%, respectively. The disease control rate was 90.91%, while the objective response rate was 21.21%.ConclusionAnlotinib proves effective in managing recurrent and symptomatic patients with Desmoid fibromatosis. However, the toxicity profile of anlotinib presents a higher risk of Hand-Foot Skin Reaction and hypertension. Therefore, given that 41.67% of patients were subjected to dose adjustments associated with the initial dose of 12 mg, implementing dosage reductions may help balance efficacy with side effects.
Scalability, test–retest reliability and validity of the Brief INSPIRE-O measure of personal recovery in psychiatric services
Authors: Moeller Stine Bjerrum , Larsen Pia Veldt , Austin Stephen , Slade Mike , Arendt Ida-Marie T. P. , Andersen Martin Stolpe , Simonsen Sebastian 
Published: May 2024

IntroductionMental health services have transitioned from treating symptoms to emphasizing personal recovery. Despite its importance, integrating personal recovery into clinical practice remains work in progress. This study evaluates the psychometric qualities of the Brief INSPIRE-O, a five-item patient-reported outcome measure assessing personal recovery.MethodThe study collected data from 2018 to 2020 at the Mental Health Services, Capital Region of Denmark, using an internet-based system examining 8,192 non-psychotic patients – receiving outpatient treatment.MaterialsThis study evaluated the Brief INSPIRE-O and used measures of symptomatology (SCL-10), well-being (WHO-5), and social functioning (modified SDS).ResultsThe study population comprised 76.8% females with a mean age of 32.9 years, and diagnoses included anxiety (28%), depression (34%), and personality disorder (19%). The mean Brief INSPIRE-O score (39.9) was lower than the general population norm (71.1). The Brief INSPIRE-O showed acceptable test–retest reliability (0.75), scalability (0.39), and internal consistency (0.73). Correlations with other mental health criteria were in the expected direction for symptomatology (−0.46), well-being (0.60), and social functioning (−0.43) and remained consistent across diagnoses.DiscussionThe Brief INSPIRE-O demonstrated strong psychometric qualities and could be recommended as a measure of personal recovery for use in both research and clinical practice. Its strong theoretical basis and short completion time make it suitable for use for research. Incorporating Brief INSPIRE-O into clinical assessment will further support the process of mental health systems re-orientating towards personal recovery.
Presidents and vaccines: head of state inoculation as a tool for vaccine promotion
Authors: Collart Lara , Lunanga Elie , Stoop Nik , Verpoorten Marijke 
Published: May 2024

IntroductionVaccine hesitancy, an important threat to global health, has increased since the onset of the COVID-19 pandemic. The public vaccination of high-profile figures, such as heads of state, has been touted as a potential tool for increasing vaccine acceptance among the general population. However, systematic information on such role modelling is lacking and existing studies focus on a small number of high-income countries. We take advantage of the COVID-19 pandemic to fill this gap.MethodsThrough a systematic search of internet sources, we first document that most global leaders supported the vaccination campaign and actively communicated their vaccination status to the public. We then turn to a case study to provide experimental evidence on vaccine role modelling for a country in Africa – the region that is most lagging behind in achieving universal immunization coverage. We rely on a randomized survey experiment with 600 citizens in the Democratic Republic of Congo and take advantage of the fact that the Congolese President publicly received a COVID-19 vaccine during the survey period.Results and discussionOur findings demonstrate that the impact of political leader’s role modelling is moderated by trust and depends on media outreach and access. When trust in leaders is lacking, or news on their actions is inaccessible, alternative ambassadors and effective communication methods become crucial in motivating and informing the public. This may be especially relevant in fragile states and remote regions.
Effects of combined ciprofloxacin and Neulasta therapy on intestinal pathology and gut microbiota after high-dose irradiation in mice
Authors: Horseman Timothy S. , Frank Andrew M. , Cannon Georgetta , Zhai Min , Olson Matthew G. , Lin Bin , Li Xianghong , Hull Lisa , Xiao Mang , Kiang Juliann G. , Burmeister David M. 
Published: May 2024

IntroductionTreatments that currently exist in the strategic national stockpile for acute radiation syndrome (ARS) focus on the hematopoietic subsyndrome, with no treatments on gastrointestinal (GI)-ARS. While the gut microbiota helps maintain host homeostasis by mediating GI epithelial and mucosal integrity, radiation exposure can alter gut commensal microbiota which may leave the host susceptible to opportunistic pathogens and serious sequelae such as sepsis. To mitigate the effects of hematopoietic ARS irradiation, currently approved treatments exist in the form of colony stimulating factors and antibiotics: however, there are few studies examining how these therapeutics affect GI-ARS and the gut microbiota. The aim of our study was to examine the longitudinal effects of Neulasta and/or ciprofloxacin treatment on the gut microbiota after exposure to 9.5 Gy 60Co gamma-radiation in mice.MethodsThe gut microbiota of vehicle and drug-treated mice exposed to sham or gamma-radiation was characterized by shotgun sequencing with alpha diversity, beta diversity, and taxonomy analyzed on days 2, 4, 9, and 15 post-irradiation.ResultsNo significant alpha diversity differences were observed following radiation, while beta diversity shifts and taxonomic profiles revealed significant alterations in Akkermansia, Bacteroides, and Lactobacillus. Ciprofloxacin generally led to lower Shannon diversity and Bacteroides prevalence with increases in Akkermansia and Lactobacillus compared to vehicle treated and irradiated mice. While Neulasta increased Shannon diversity and by day 9 had more similar taxonomic profiles to sham than ciprofloxacin-or vehicle-treated irradiated animals. Combined therapy of Neulasta and ciprofloxacin induced a decrease in Shannon diversity and resulted in unique taxonomic profiles early post-irradiation, returning closer to vehicle-treated levels over time, but persistent increases in Akkermansia and Bacteroides compared to Neulasta alone.DiscussionThis study provides a framework for the identification of microbial elements that may influence radiosensitivity, biodosimetry and the efficacy of potential therapeutics. Moreover, increased survival from H-ARS using these therapeutics may affect the symptoms and appearance of what may have been subclinical GI-ARS.
miR-29 as diagnostic biomarkers for tuberculosis: a systematic review and meta-analysis
Authors: He Jie , Xiong Juan , Huang Yuanyuan 
Published: May 2024

BackgroundThe timely diagnosis of tuberculosis through innovative biomarkers that do not rely on sputum samples is a primary focus for strategies aimed at eradicating tuberculosis. miR-29 is an important regulator of tuberculosis pathogenesis. Its differential expression pattern in healthy, latent, and active people who develop tuberculosis has revealed its potential as a biomarker in recent studies. Therefore, a systematic review and meta-analysis were performed for the role of miR-29 in the diagnosis of tuberculosis.MethodsEMBASE, PubMed, CNKI, Web of Science, and Cochrane Library databases were searched utilizing predefined keywords for literature published from 2000 to February 2024.Included in the analysis were studies reporting on the accuracy of miR-29 in the diagnosis of tuberculosis, while articles assessing other small RNAs were not considered. All types of study designs, including case–control, cross-sectional, and cohort studies, were included, whether prospectively or retrospectively sampled, and the quality of included studies was determined utilizing the QUADAS-2 tool. Publication bias was analyzed via the construction of funnel plots. Heterogeneity among studies and summary results for specificity, sensitivity, and diagnostic odds ratio (DOR) are depicted in forest plots.ResultsA total of 227 studies were acquired from the various databases, and 18 articles were selected for quantitative analysis. These articles encompassed a total of 2,825 subjects, primarily sourced from the Asian region. Patient specimens, including sputum, peripheral blood mononuclear cells, cerebrospinal fluid and serum/plasma samples, were collected upon admission and during hospitalization for tuberculosis testing. miR-29a had an overall sensitivity of 82% (95% CI 77, 85%) and an overall specificity of 82% (95% CI 78, 86%) for detecting tuberculosis. DOR was 21 (95% CI 16–28), and the area under the curve was 0.89 (95% CI 0.86, 0.91). miR-29a had slightly different diagnostic efficacy in different specimens. miR-29a showed good performance in both the diagnosis of pulmonary tuberculosis and extrapulmonary tuberculosis. miR-29b and miR-29c also had a good performance in diagnosis of tuberculosis.ConclusionAs can be seen from the diagnostic performance of miR-29, miR-29 can be used as a potential biomarker for the rapid detection of tuberculosis.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=461107.
Cover Crops and Tillage: Effects on Soil Chemical Properties and Rice Yield
Authors: Nascimento Vagner do , Arf Orivaldo , Alves Marlene Cristina , de Souza Epitácio José , da Silva Paulo Ricardo Teodoro , Kaneko Flávio Hiroshi , Teixeira Filho Marcelo Carvalho Minhoto , Prado Evandro Pereira , Ferrari Samuel , de Souza Loiane Fernanda Romão , Galindo Fernando Shintate 
Published: May 2024

Mechanical soil intervention with a chisel in cover crops (CCs) is a promising strategy for minimizing the superficial compaction of soil in a no-tillage system (NTS). The objective of this study was to evaluate the effect of mechanical chiseling associated with successive crops and preceding cover crops to assess grain yield and changes in soil chemical properties after rice cultivation for two consecutive years. The experimental design comprised randomized blocks in a 5 × 2 factorial scheme with four replications. The treatments consisted of five cover crops (Cajanus cajan, Crotalaria juncea, Urochloa ruziziensis, Pennisetum glaucum, and fallow), with or without soil mechanical chiseling. Soil samples from the 0–5, 5–10, 10–20, and 20–40 cm layers were collected, and the chemical properties were analyzed after rice cultivation. Under U. ruziziensis, the chemical properties were improved by mechanical scarification; however, the initial acidity increased in the 5–40 cm layer. The cultivation of P. glaucum and C. juncea prior to rice, regardless of scarification, improved the soil chemical properties in the 0–40 cm layer. Mechanical soil scarification and the use of C. cajan as a cover crop increased the grain yield of upland rice by approximately 552 and 1454 and 1330 kg ha−1 compared to the P. glaucum and U. ruziziensis, respectively.
A influência dos antioxidantes na longevidade
Authors: Lima Milena Procópio de , Carvalho Maria das Graças Freitas de 
Published: May 2024

O envelhecimento é um processo fisiológico caracterizado por diversas alterações metabólicas, muitas delas devido ao acúmulo de radicais livres provenientes do estresse oxidativo e dos processos inflamatórios acumulados durante a vida. A nutrição ótima é fundamental para o processo de envelhecimento, pois pode determinar a proteção para os efeitos deletérios do estresse oxidativo. O presente trabalho, tem como objetivo revisar o papel das principais substâncias antioxidantes da alimentação na longevidade. Trata-se de revisão simples de literatura, cuja busca foi realizada nas bases de dados Pubmed e Google acadêmico. Foram consideradas para esse trabalho artigos científicos e monografias publicados no período de 1999 a 2023. Foram utilizados os seguintes descritores: alimento funcional, antioxidantes, estresse oxidativo, longevidade e radicais livres. Os critérios de exclusão foram: artigos relacionados à animais, dermatologia, gestantes e atletas. Foram resgatados 1383 arquivos dos quais 11 foram selecionados após aplicação dos critérios de exclusão. Os estudos analisados apontam como principais antioxidantes a Vitamina C, o selênio, o resveratrol, dentre outros. Esses, agem promovendo efeitos benéficos sobre vias oxidativas redox, vias mitocondriais no sistema imunológico, atuam sobre a função da enzima peroxidase, da glutationa, além do bloqueio das citocinas inflamatórias. Conclui-se que o consumo de alimentação rica em compostos antioxidantes são fundamentais para melhoria da saúde e aumento da longevidade humana, em conjunto com uma série de hábitos de vida saudáveis.
Doença Pulmonar Intersticial como manifestação de doença reumática autoimune: relato de caso e revisão de conceitos
Authors: Carvalho Ana Tércia Beltrame , Oliveira Bárbara de , Silva Bianca Veloso Ferraz de Oliveira , Mello Marcella Maria Soares 
Published: May 2024

A síndrome antissintetase é uma doença autoimune caracterizada pela produção de autoanticorpos contra RNA sintetase de transferência de aminoacil (RNAt). Os achados clínicos incluem miopatia inflamatória, doença pulmonar intersticial, achados dermatológicos, também chamados de "mãos de mecânico", artrite inflamatória e fenômeno de Raynaud. As doenças pulmonares intersticiais são definidas como um grupo heterogêneo de distúrbios do tecido pulmonar que são classificados juntos devido às manifestações clínicas, radiográficas, fisiológicas ou patológicas semelhantes. Relatar o caso da progressão da doença pulmonar intersticial em uma paciente portadora de síndrome antissintetase, bem como os métodos diagnósticos, a progressão radiológica e o prognóstico do tratamento com terapia imunossupressora utilizada. Relato de caso de uma paciente de 71 anos com história de dispneia progressiva e fenômeno de Raynaud associado à revisão sistemática da literatura relacionada ao tema. Após extensa propedêutica, a paciente recebeu o diagnóstico de síndrome antissintetase, uma doença autoimune com elevada prevalência de doença pulmonar intersticial. O tratamento inclui corticosteroides e imunossupressores, como ciclofosfamida e micofenolato de mofetila. A síndrome antissintetase é uma doença rara cujo diagnóstico precoce e tratamento correto são essenciais para alcançar bons resultados e reduzir a morbimortalidade dos pacientes.