bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sintering behaviors and microwave dielectric properties of BaO–MgO–SiO2 ternary ceramics
Authors: Pang Li‐Xia , Fang Zhen , Zhou Di , Wang Wei , Shi Zhong‐Qi , Hussain Fayaz , Darwish Moustafa Adel , Zhou Tao , Sun Shi‐Kuan , Liang Qi‐Xin , Chen Ya‐Wei 
Published: May 2024

AbstractIn the present work, five compositions in the BaO–MgO–SiO2 ternary system were chosen, and ceramics were prepared using the solid‐state reaction method. Single phases were formed easily for the first four compositions, and BaMgSi3O8 ceramics were found to be a mixture of both BaSi2O5 and MgSiO3, according to X‐ray diffraction results. Among all the compositions, Ba2MgSi2O7 ceramic sintered at 1225°C possesses the highest Qf (Q = 1/dielectric loss = 1/tanδ, f = resonant frequency) value ∼55 010 GHz along with relative permittivity ∼8.0 and temperature coefficient of resonant frequency (TCF) ∼−57.5 ppm/°C. With 3 wt.% BCB (BaO–B2O3–CuO) additions, Ba2MgSi2O7 ceramic was well densified at 950°C with a relative permittivity ∼8.1, Qf value ∼28 920 GHz (at 12.37 GHz) and TCF value ∼‒56.6 ppm/°C. These series ceramics with low relative permittivity values might be good candidates for low‐temperature co‐fire ceramic technology substrate applications.
Curcumin is effective in managing oral inflammation: An in vitro study
Authors: Idrees Majdy , Kujan Omar 
Published: May 2024

AbstractBackgroundOral inflammation is among the most prevalent oral pathologies with systemic health implications, necessitating safe and effective treatments. Given curcumin's documented anti‐inflammatory and antioxidant properties, this study focuses on the potential of a curcumin‐based oral gel in safely managing oral inflammatory conditions.MethodsThis in vitro study utilized four human cell lines: oral keratinocytes (HOKs), immortalized oral keratinocytes (OKF6), periodontal ligament fibroblasts (HPdLF), and dysplastic oral keratinocytes (DOKs). The cells were treated with Lipopolysaccharides (LPS) and curcumin‐based oral gel to simulate inflammatory conditions. A panel of cellular assays were performed along with antimicrobial efficacy tests targeting Candida albicans, Streptococcus mutans, and Porphyromonas gingivalis.ResultsLPS significantly reduced proliferation and wound healing capacities of HOKs, OKF6, and HPdLF, but not DOKs. Treatment with curcumin‐based oral gel mitigated inflammatory responses in HOKs and HPdLF by enhancing proliferation, colony formation, and wound healing, along with reducing apoptosis. However, its impact on OKF6 and DOKs was limited in some assays. Curcumin treatment did not affect the invasive capabilities of any cell line but did modulate cell adhesion in a cell line‐specific manner. The curcumin‐based oral gel showed significant antimicrobial efficacy against C. albicans and S. mutans, but was ineffective against P. gingivalis.ConclusionThis study demonstrates the potential of the curcumin‐based oral gel as a safe and effective alternative to conventional antimicrobial treatments for managing cases of oral inflammation. This was achieved by modulating cellular responses under simulated inflammatory conditions. Future clinical‐based studies are recommended to exploit curcumin's therapeutic benefits in oral healthcare.
Melatonin reduces brain injury following inflammation‐amplified hypoxia–ischemia in a translational newborn piglet study of neonatal encephalopathy
Authors: Pang Raymand , Meehan Christopher , Maple George , Norris Georgina , Campbell Ellie , Tucker Katie , Mintoft Alison , Torrealdea Francisco , Bainbridge Alan , Hristova Mariya , Barks John , Golay Xavier , Standing Joseph , Robertson Nicola J. 
Published: May 2024

AbstractThere is a need to develop therapies for neonatal encephalopathy (NE) in low‐ and middle‐income countries (LMICs) where the burden of disease is greatest and therapeutic hypothermia (HT) is not effective. We aimed to assess the efficacy of melatonin following inflammation‐amplified hypoxia–ischaemia (IA‐HI) in the newborn piglet. The IA‐HI model accounts for the contribution of infection/inflammation in this setting and HT is not cytoprotective. We hypothesised that intravenous melatonin (5% ethanol, at 20 mg/kg over 2 h at 1 h after HI + 10 mg/kg/12 h between 24 and 60 h) is safe and associated with: (i) reduction in magnetic resonance spectroscopy lactate/N‐acetylaspartate (MRS Lac/sNAA); (ii) preservation of phosphorus MRS phosphocreatine/phosphate exchange pool (PCr/Epp); (iii) improved aEEG/EEG recovery and (iv) cytoprotection on immunohistochemistry. Male and female piglets underwent IA‐HI by carotid artery occlusion and reduction in FiO2 to 6% at 4 h into Escherichia coli lipopolysaccharide sensitisation (2 μg/kg bolus + 1 μg/kg/h over 12 h). At 1 h after IA‐HI, piglets were randomised to HI‐saline (n = 12) or melatonin (n = 11). There were no differences in insult severity between groups. Target melatonin levels (15–30 mg/L) were achieved within 3 h and blood ethanol levels were <0.25 g/L. At 60 h, compared to HI‐saline, melatonin was associated with a reduction of 0.197 log10 units (95% CrI [−0.366, −0.028], Pr(sup) 98.8%) in basal‐ganglia and thalamic Lac/NAA, and 0.257 (95% CrI [−0.676, 0.164], Pr(sup) 89.3%) in white matter Lac/NAA. PCr/Epp was higher in melatonin versus HI‐saline (Pr(sup) 97.6%). Melatonin was associated with earlier aEEG/EEG recovery from 19 to 24 h (Pr(sup) 95.4%). Compared to HI‐saline, melatonin was associated with increased NeuN+ cell density (Pr(sup) 99.3%) across five of eight regions and reduction in TUNEL‐positive cell death (Pr(sup) 89.7%). This study supports the translation of melatonin to early‐phase clinical trials. Melatonin is protective following IA‐HI where HT is not effective. These data guide the design of future dose‐escalation studies in the next phase of the translational pipeline.
IAIH‐PG consensus for histological criteria of AIH: Multicentre validation with focus on chronic liver diseases in China
Authors: Wang Li , Du Zhi‐Xiang , Liu Hong‐Li , Zhang Yu , Wang Shuang‐Shuang , Hu Yi‐Fan , Li Li‐Qiu , Zhu Ping , Zhong Yan‐Dan , Xiong Qing‐Fang , Yang Yong‐Feng 
Published: May 2024

AbstractBackground and AimsThe International AIH Pathology Group (IAIH‐PG) put forward the new histological criteria of autoimmune hepatitis (AIH) in 2022, which have not undergone adequate verification. In this study, we verified the applicability of the new histological criteria in the population of Chinese patients with chronic liver disease, comparing it with the simplified criteria.MethodsThe gold standard for diagnosis in all patients was based on histological findings, combined with clinical manifestations and laboratory tests and determined after a follow‐up period of at least 3 years. A total of 640 patients with various chronic liver diseases from multiple centres underwent scoring using the new histological criteria and the simplified criteria, comparing their diagnostic performance.ResultsIn this study, the new histological criteria showed a sensitivity of 73.6% and 100% for likely and possible AIH, with specificities of 100% and 69.0% respectively. The coincidence rates of possible AIH for the new histological criteria, simplified histological criteria and simplified score were 81.7%, 72.8% and 69.7% respectively. For likely AIH, the rates were 89.2%, 75.9% and 65.6% respectively. Based on the new histological criteria, all patients with AIH were correctly diagnosed. Specifically, 73.6% were diagnosed with likely AIH and 26.4% were possible AIH. Additionally, the simplified histological criteria achieved a diagnosis rate of 98.6% for AIH, while the simplified score could only diagnose 53.8% of AIH.ConclusionsCompared with the simplified score and simplified histological criteria, the sensitivity and specificity of the new histological criteria for AIH were significantly improved. The results indicate that the new histological criteria exhibit high sensitivity and specificity for diagnosing AIH in China.
Nasopharyngeal airway assistance improves esophageal intubation rates of high‐resolution esophageal manometry catheters
Authors: Leopold Andrew , Wu Angela , Xie Guofeng 
Published: May 2024

AbstractBackgroundHigh‐resolution esophageal manometry (HREM) is the gold standard test for esophageal motility disorders. Nasopharyngeal airway‐assisted insertion of the HREM catheter is a suggested salvage technique for failure from the inability to pass the catheter through the upper esophageal sphincter (UES). It has not been demonstrated that the nasopharyngeal airway improves procedural success rate.MethodsPatients undergoing HREM between March 2019 and March 2023 were evaluated. Chart review was conducted for patient factors and procedural success rates before and after use of nasopharyngeal airway. Patients from March 2019 to May 2021 did not have nasopharyngeal airway available and were compared to patients from May 2021 to March 2023 who had the nasopharyngeal airway available.Key ResultsIn total, 523 HREM studies were conducted; 234 occurred prior to nasopharyngeal airway availability, and 289 occurred with nasopharyngeal airway availability. There was no difference in HREM catheter UES intubation rates between periods when a nasopharyngeal airway attempt was considered procedural failure (85% vs. 85%, p = 0.9). Nasopharyngeal airway use after UES intubation failure lead to improved UES intubation rates (94% vs. 85%, p < 0.01). Thirty‐six patients that failed HREM catheter UES intubation had the procedure reattempted with a nasopharyngeal airway, 30 (83%) of which were successful. The nasopharyngeal airway assisted catheter UES intubation for failures attributed to nasal pain and hypersensitivity, gagging, coughing, and pharyngeal coiling.Conclusions & InferencesUtilization of the nasopharyngeal airway increased rates of UES intubation. When HREM catheter placement through the UES fails, placement of a nasopharyngeal airway can be trialed to overcome patient procedural intolerance.
Reducing postoperative hypothermia in infants: Quality improvement in China
Authors: Qiu Qianqi , Yang Zixin , Zhang Yong , Zeng Wen , Yang Kuiyan , Liang Cuiping , Alifu Ailixiati , Huang Haibo , Chen Jun , Zhang Meixue , Wu Dongmei , Guo Xiaoping , Jin Saifen , Lin Yuzhen , Chuo John , Zhang Huayan , Song Xingrong , Iyer Rajeev S. 
Published: May 2024

AbstractBackgroundUnintended postoperative hypothermia in infants is associated with increased mortality and morbidity. We noted consistent hypothermia postoperatively in more than 60% of our neonatal intensive care (NICU) babies. Therefore, we set out to determine whether a targeted quality improvement (QI) project could decrease postoperative hypothermia rates in infants.ObjectivesOur SMART aim was to reduce postoperative hypothermia (<36.5°C) in infants from 60% to 40% within 6 months.MethodsThis project was approved by IRB at Guangzhou Women and Children's Medical Center, China. The QI team included multidisciplinary healthcare providers in China and QI experts from Children's Hospital of Philadelphia, USA. The plan‐do‐study‐act (PDSA) cycles included establishing a perioperative‐thermoregulation protocol, optimizing the transfer process, and staff education. The primary outcome and balancing measures were, respectively, postoperative hypothermia and hyperthermia (axillary temperature < 36.5°C, >37.5°C). Data collected was analyzed using control charts. The factors associated with a reduction in hypothermia were explored using regression analysis.ResultsThere were 295 infants in the project. The percentage of postoperative hypothermia decreased from 60% to 37% over 26 weeks, a special cause variation below the mean on the statistical process control chart. Reduction in hypothermia was associated with an odds of 0.17 (95% CI: 0.06–0.46; p <.001) for compliance with the transport incubator and 0.24 (95% CI: 0.1–0.58; p =.002) for prewarming the OR ambient temperature to 26°C. Two infants had hyperthermia.ConclusionsOur QI project reduced postoperative hypothermia without incurring hyperthermia through multidisciplinary team collaboration with the guidance of QI experts from the USA.
Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome to Hemodialysis Polysulfone Membrane
Authors: Inoue Masatoshi , Sasamoto Momoko , Ichihara Ryosuke 
Published: May 2024

ABSTRACTDrug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe and potentially life‐threatening hypersensitivity reaction. Although commonly associated with specific drugs, there have been no reports of DRESS syndrome caused by medical devices. We report a unique case of DRESS syndrome linked to a particular hemodialysis membrane during treatment. An 83‐year‐old man on hemodialysis exhibited fever, rash, and elevated eosinophils. Despite medication changes and consultations with specialists, his condition persisted. A drug‐induced lymphocyte stimulation test revealed a positive response to the dialysis membrane. His symptoms and lab results met DRESS syndrome diagnostic criteria. After substituting the membrane and administering glucocorticoids, the patient displayed early improvement. Diagnosing DRESS syndrome is complex due to its varied presentation and lack of specific benchmarks. This instance underscores the need to consider medical devices as potential DRESS syndrome triggers. Enhanced physician awareness can facilitate prompt detection and proper management, ultimately refining patient outcomes.
Proximalization of Arterial Inflow for the Treatment of Limb Ischemia in a Transposed Femoral Arteriovenous Fistula—A Case Report
Authors: Veterano Carlos Filipe Pinho , de Almeida Paulo Jorge Carvalho , Rego Duarte Nuno Cunha , Loureiro Luís Pedro Martins Macedo Alvarenga , Pinto Pedro Jorge Sá , Machado Rui Manuel Vieira Mota 
Published: May 2024

ABSTRACTIntroductionFemoral vein transposition is one of the final resorts for vascular access in patients with exhaustion of upper limb venous patrimony and central venous occlusive disease. Its major pitfalls include hemodialysis access‐induced distal ischemia and infection. Surgical procedures may be warranted to preserve vascular access if ischemia develops. Several techniques are reported in the literature for femoral vein transposition.Case ReportWe expose an endoscopic femoral vein harvesting as an alternative to the single thigh incision in order to avoid its associated complications. In the setting of ischemia, proximalization of arterial inflow was used to manage femoral vein transposition associated limb ischemia.ConclusionThis case report aims to expose the aforementioned unreported surgical techniques for lower limb arteriovenous fistula, its advantages, and pitfalls, as well as considerations on its future use.
Comparison of coagulation and fibrinolysis in Irish Wolfhounds and age‐matched control dogs using tissue plasminogen activator‐augmented viscoelastic testing
Authors: Davis Samantha , Fletcher Daniel J. , Newman Ashley , Brooks Marjory B. 
Published: May 2024

AbstractObjectiveTo determine if Irish Wolfhounds (IWs), like other sighthounds, are hyperfibrinolytic compared with nonsighthound dogs using 2 native and tissue plasminogen activator (tPA)‐enhanced viscoelastic assays, one that is whole blood‐based (viscoelastic coagulation monitor [VCM]) and the other that is plasma‐based thromboelastography (TEG).DesignCohort study.SettingUniversity teaching hospital.AnimalsA convenience sample of 27 IWs recruited from the Irish Wolfhound Association of New England Specialty and the local community, and 27 healthy, age‐matched, large‐breed control dogs.InterventionsNone.Measurements and Main ResultsBlood samples including CBC, biochemistry, traditional coagulation, and viscoelastic testing were collected from IWs and control dogs. Twelve IWs had viscoelastic testing. IWs had lower fibrinogen concentrations (215.5 ± 57.8 vs 251.4 ± 64.5 mg/dL, P = 0.034) and formed weaker clots on both whole‐blood VCM and plasma TEG assays (maximum clot firmness [VCM‐MCF] = 39.4 [25.1–48.8] vs 48.5 [34.6–57.3], P = 0.0042; maximum amplitude [TEG‐MA] = 22.7 [14.7–33.6] vs 32.2 [26.9–42.0], P < 0.0001). IWs were hyperfibrinolytic compared with control dogs on VCM whole‐blood assays, with 25 U/mL tPA (lysis at 30 min [VCM‐LI30] = 68.1 [0–100] vs\ 99.9 [63.3–100], P = 0.0009; lysis at 45 min [VCM‐LI45] = 31.0 [0–100] vs 98.1 [38.4–100], P = 0.0002) but hypofibrinolytic compared with controls on TEG plasma assays with 50 U/mL tPA (lysis at 30 min [TEG‐LY30] = 45.7 [4.6–94.6] vs 93.7 [12.3–96.5], P = 0.0004; lysis at 60 min [TEG‐LY60] = 68.7 [29.7–96.8] vs 95.7 [34.4–97.6], P = 0.0003). Minimal fibrinolysis was measured on whole‐blood VCM or plasma TEG assays without the addition of tPA, and there were no differences between the 2 groups.ConclusionsWeaker clots were found in IWs than control dogs. With the addition of tPA, IWs had evidence of hyperfibrinolysis on whole‐blood VCM assays and hypofibrinolysis on plasma TEG assays compared with control dogs. Without the addition of tPA, however, both groups of dogs showed minimal fibrinolysis on viscoelastic testing.
Linguistic and literary creativity in Philippine Englishes
Authors: Martin Isabel Pefianco 
Published: May 2024

AbstractCreativity in Englishes in the Philippines is evident in both literary and non‐literary works produced in current contexts of multilingualism. The term ‘creativity’ is traditionally associated with language use in literary texts, suggesting that a systematic study of creativity in language use lies only in the esoteric fields of literary studies and creative writing. However, I wish to approach ‘creativity’ in the sense of what Carter describes as ‘not simply a property of exceptional people but an exceptional property of all people’. I approach creativity in Englishes in the Philippines as ‘everyday creativity’, beginning with a discussion of Braj Kachru's concept of ‘bilinguals’ creativity’, introduced in a 1985 groundbreaking work. This Kachruvian concept of creativity is revisited in the light of 21st century sociolinguistic realities. In this revisiting, I extend the concept of bilinguals’ creativity beyond traditional approaches to creativity in English language use.
Teachers’ Beliefs and Dispositions Toward Change in a Social and Emotional Skills Development Program
Authors: Pennington Shannon A. , Graber Kim C. , Gaudreault Karen Lux , Richards Kevin Andrew 
Published: May 2024

Noncore subject teachers often experience marginalization due to perceptions that their work is undervalued. Social and emotional skill-focused continuous professional development can help teachers address the stress associated with marginalization. Purpose: Grounded in the integrative model for teacher change, this study examined the ways in which elementary-level noncore subject teachers’ dispositions toward change influenced their experiences with a social and emotional skills development intervention. Method: This study included two iterations of the program with a total of 21 elementary-level noncore subject teachers (e.g., physical education, art, and music) from three districts in the Midwestern United States. Data included a survey, semistructured interviews, document analysis, discussion board posts, observations, and field notes. Collaborative qualitative analysis was used to analyze multiple data sources line by line. Results: Marginalization and low perceived mattering were prevalent among participants. A positive disposition toward change enhanced the influence of the professional learning, and participants found the experience validating. Conclusions: Teachers of marginalized subjects need to feel seen and heard. A positive disposition toward change drew teachers to participate, and the camaraderie formed was a motivator for teachers who felt undervalued.
Physical Educators’ Attitudes Toward Teaching Students With Disabilities After a Paralympic School Day Professional Development Program
Authors: Leake Marie , Block Martin E. , Fines Abby , McKay Cathy 
Published: May 2024

Purpose: This study aimed to examine physical educators’ attitudes toward teaching students with disabilities in general physical education after participating in a Paralympic School Day professional development program. Methods: Elementary through high school physical education teachers participated in a Paralympic School Day professional development program. Data from focus groups and written reflections were analyzed deductively and inductively using a three-step approach. Results: The analysis revealed five interrelated themes: (a) “you’re trying to accommodate everyone, and so it’s hard”; (b) “putting yourself in other people’s shoes”; (c) “I definitely want to use these ideas”; (d) “It made me think about all of my students”; and (e) “not talking is the hurtful action.” Discussion: Following the Paralympic School Day professional development program, physical educators described a shift in attitudes characterized by a desire to implement inclusive teaching practices and an enhanced focus on promoting conversations with individuals with disabilities.
NPP-669, a prodrug of cidofovir, is highly efficacious against human adenovirus infection in the permissive Syrian hamster model
Authors: Tollefson Ann E. , Cline-Smith Anna B. , Spencer Jacqueline F. , Reyna Dawn M. , Lipka Elke , Toth Karoly 
Published: May 2024

ABSTRACT

Human adenoviruses can cause serious, disseminated infections in immunocompromised patients. For pediatric allogeneic stem cell transplant patients, the case fatality rate can reach 80%. Still, there is no available antiviral drug that is specifically approved by the Food and Drug Administration for the treatment of adenovirus infections. To fill this pressing medical need, we have developed NPP-669, a prodrug of cidofovir with broad activity against double-stranded DNA viruses, including adenoviruses. Here, we report on the
in vivo
anti-adenoviral efficacy of NPP-669. Using the immunosuppressed Syrian hamster as the model, we show that NPP-669 is highly efficacious when dosed orally at 1 mg/kg and 3 mg/kg. In a delayed administration experiment, NPP-669 was more effective than brincidofovir, a similar compound that reached Phase III clinical trials. Furthermore, parenteral administration of NPP-669 increased its efficacy approximately 10-fold compared to oral dosing without apparent toxicity, suggesting that this route may be preferable in a hospital setting. Based on these findings, we believe that NPP-669 is a promising new compound that needs to be further investigated.