bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Convenient Electrochemical Method for the Synthesis of α‐Bromo Alkyl Aryl Ketones.
Authors: Kumar R. Senthil , Kulangiappar K. , Kulandainathan M. Anbu 
Published: October 2010

Abstractα‐Bromoalkyl carbonyl compounds are produced in high yields by electrochemical bromination of carbonyl compounds by hydrobromic acid in acetonitrile.
ChemInform Abstract: Construction of Quaternary Stereogenic Carbon Centers by the Lewis Base Catalyzed Conjugate Addition of Silyl Ketene Imines to α,β‐Unsaturated Aldehydes and Ketones.
Authors: Denmark Scott E. , Wilson Tyler W. 
Published: October 2010

AbstractAxially chiral bisphorphoramides in the presence of SiCl4 provide an efficient site‐selective approach to nitrile products via the title reaction.
ChemInform Abstract: One‐Pot Three‐Component Synthesis of α‐Aminonitriles Using Potassium Hexacyanoferrate(II) as an Eco‐Friendly Cyanide Source.
Authors: Li Zheng , Ma Yuanhong , Xu Jun , Shi Jinghong , Cai Hongfang 
Published: October 2010

AbstractBenzoyl chloride is found to be an efficient promotor for the condensation of aldehydes or ketones with amines and cyanide ions.
ChemInform Abstract: A Novel and Convenient Approach for Tosyloxylation of Aromatic Ring of Some ortho‐Substituted Phenolic Compounds Using [Hydroxy(tosyloxy)iodo]benzene.
Authors: Prakash Om , Kumar Manoj , Kumar Rajesh 
Published: October 2010

AbstractThe novel tosylation of substituted phenols is greatly influenced by the electronic effect and position of the aromatic substituent.
ChemInform Abstract: Enantioselective Construction of Indanones from Cyclobutanols Using a Rhodium‐Catalyzed C—C/C—H/C—C Bond Activation Process.
Authors: Seiser Tobias , Cathomen Gino , Cramer Nicolai 
Published: October 2010

AbstractThe cleavage of the cyclobutanols proceeds in the presence of a catalyst system including chiral ligand DFP and is followed by cyclization and elimination of the thienyl substituent to provide indanone derivatives with high levels of enantioselectivity.
ChemInform Abstract: Efficient One‐Pot Synthesis of 2‐Azetidinones from Acetic Acid Derivatives and Imines Using Methoxymethylene‐N,N‐dimethyliminium Salt.
Authors: Jarrahpour Aliasghar , Zarei Maaroof 
Published: October 2010

AbstractA wide variety of 2‐azetidinones (38 examples) is prepared, including spirocyclic, N‐alkyl, 3‐chloro, and 3‐azido derivatives.
ChemInform Abstract: Combination of Novozym 435‐Catalyzed Hydrolysis and Mitsunobu Reaction for Production of (R)‐γ‐Lactones.
Authors: Shimotori Yasutaka , Miyakoshi Tetsuo 
Published: October 2010

AbstractWith a view to obtaining the naturally occurring (R)‐lactones, the resolution of racemic acetates, e.g. (I), is combined with a Mitsunobu reaction for the inversion of obtained (S)‐alcohols, cf.
ChemInform Abstract: γ‐Hydroxynitrile Alkylations: Electrophile‐Dependent Stereoselectivity.
Authors: Mycka Robert J. , Steward Omar W. , Fleming Fraser F. 
Published: October 2010

AbstractThe dependence of the diastereoselectivity of the reaction of the starting γ‐hydroxynitriles on the nature of the electrophiles is investigated.
ChemInform Abstract: Synthesis and Bioactivity of Novel N,N′‐Diacylhydrazine Derivatives Containing Furan.
Authors: Cui Zining , Zhang Li , Huang Juan , Yang Xinling , Ling Yun 
Published: October 2010

AbstractSome substances exhibit potential activity against selected human cancer cell lines and good larvicidal activity against Mythimna separate (42 examples).
ChemInform Abstract: A Novel Synthesis of Calix[4]thiophenes and Calix[4]furans.
Authors: Lee Gon‐Ann , Wang Wen‐Chieh , Shieh Minghuey , Kuo Ting‐Shen 
Published: October 2010

AbstractThe reaction of furan or thiophene with ketones (II) followed by dehydration of intermediate alcohols and subsequent NIS‐catalyzed tetramerization of resulting alkenes gives rise to calix[4]furans and calix[4]thiophenes (III), resp., in good overall yields.
ChemInform Abstract: Synthesis and Biological Evaluation of 1‐Cyclohexyl Substituted 3‐Aminopyrrolidine Derivatives as CC Chemokine Receptor 2 (CCR2) Antagonists.
Authors: Lim Jee Woong , et al. et al. 
Published: October 2010

AbstractThe 1‐cyclohexyl substituted 3‐aminopyrrolidine derivatives having a morpholine or thiomorpholine at the C‐4 position of the cyclohexyl group (II) are found to be good CCR2 antagonists.
ChemInform Abstract: Asymmetric Synthesis of Indolines Bearing a Benzylic Quaternary Stereocenter Through Intramolecular Arylcyanation of Alkenes.
Authors: Hsieh Jen‐Chieh , Ebata Shiro , Nakao Yoshiaki , Hiyama Tamejiro 
Published: October 2010

AbstractConditions A) in combination with chiral phosphinooxazoline ligands allows the enantioselective preparation of 3,3‐disubstituted indolines, which represent biologically interesting substructures of alkaloids.
ChemInform Abstract: Highly Diastereo‐ and Enantioselective Michael Additions of 3‐Substituted Oxindoles to Maleimides Catalyzed by Chiral Bifunctional Thiourea—Tertiary Amine.
Authors: Liao Yu‐Hua , Liu Xiong‐Li , Wu Zhi‐Jun , Cun Lin‐Feng , Zhang Xiao‐Mei , Yuan Wei‐Cheng 
Published: October 2010

AbstractThe reaction tolerates a variety of substituents at the C3‐ and C5‐positions of the indoles and various N‐substituents in maleimides (II).
ChemInform Abstract: Cinchona Alkaloid/TiIV‐Catalyzed Enantioselective Enamine—Trifluoropyruvate Condensation—Cyclization Reaction and Its Application to Drug‐Like Heterocycles.
Authors: Ogawa Shinichi , Iida Norihito , Tokunaga Etsuko , Shiro Motoo , Shibata Norio 
Published: October 2010

AbstractThe enantioselective enamine/trifluoropyruvate condensation features the synthesis of a series of fused pyrrole derivatives such as (III), (IX), (XI), or (XIII).
ChemInform Abstract: Ag—TiO2/Clay Composite Photocatalyst for the Oxidation—Cyclization of 1,2‐Diamine Compounds with Propylene Glycol or Alcohols.
Authors: Selvam Kaliyamoorthy , Annadhasan Mari , Velmurugan Rengasamy , Swaminathan Meenakshisundaram 
Published: October 2010

AbstractThe title catalyst is successfully applied to the synthesis of benzimidazoles using solar light or UV‐A.
ChemInform Abstract: Synthesis of Novel β‐Lactam Fused Spiroisoxazolidine Chromanones and Tetralones as Potent Antimicrobial Agent for Human and Plant Pathogens.
Authors: Arumugam Natarajan , Raghunathan Raghavachary , Shanmugaiah Vellaisamy , Mathivanan Narayanasamy 
Published: October 2010

AbstractThe synthesis of the novel β‐lactam fused spiroisoxazolidine tetralone and chromanone ring systems (III) is achieved by intermolecular 1,3‐dipolar cycloaddition reaction of nitrone (I) with the unusual dipolarophiles (II).
ChemInform Abstract: A Fast and Highly Efficient Protocol for Synthesis of Pyrrolo[2,3‐d]isoxazoles (IV) and a New Series of Novel Benzyl Bis‐pyrrolo[2,3‐d]isoxazoles (VIII) Using Task‐Specific Ionic Liquids as Catalyst and Green Solvent.
Authors: Rajanarendar Eligeti , Raju Samala , Reddy Atthunuri Siva Rami , Reddy Kundur Govardhan , Reddy Modugu Nagi 
Published: October 2010

AbstractThe ionic liquids play a dual role of green solvent as well as efficient and recyclable catalyst.
ChemInform Abstract: One‐Pot, Pseudo‐Five‐Component Synthesis of Bis[2‐(arylimino)‐1,3‐thiazolidin‐4‐ones].
Authors: Alizadeh Abdolali , Noaparast Zohreh , Sabahno Hamideh , Zohreh Nasrin 
Published: October 2010

AbstractThe title compounds are obtained from aliphatic diamines.
ChemInform Abstract: Microwave‐Assisted Amination of 3‐Bromo‐2‐chloropyridine with Various Substituted Aminoethanols.
Authors: Kim Jeong Geun , Yang Eun Hae , Youn Woo Sup , Choi Ji Won , Ha Deok‐Chan , Ha Jae Du 
Published: October 2010

AbstractThe process allows the preparation of a broad spectrum of amino alcohols.
ChemInform Abstract: Convenient One‐Pot Synthesis of Fluorinated DHPs Derivatives and Their Further Transformations.
Authors: Wang Pengyuan , Song Liping , Yi Hai , Zhang Min , Zhu Shizheng , Deng Hongmei , Shao Min 
Published: October 2010

AbstractThe four‐component reaction proceeds via initial Michael addition and a subsequent intramolecular cyclization to give trifluoromethyl substituted piperidines, which are dehydrated to the corresponding dihydropyridine derivatives.
ChemInform Abstract: Gold(I)‐Catalyzed Cycloisomerization of the Mixed N,S‐Acetals Generated from Homopropargylic Amines; Mechanistic Implication for the Formal Alkyne Prins Reaction.
Authors: Kim Cheoljae , Lim Wontaeck , Rhee Young Ho 
Published: October 2010

AbstractCycloisomerization of N,S‐ or N,O‐acetals [(I) or (III), resp.] leads to piperidinones (II), whereas compound (IV) having an additional alkyl group at the propargylic position yields thioether (V).
ChemInform Abstract: Spontaneous Conversion of 2‐Azido‐3‐nitropyridines to Pyridofuroxans.
Authors: Leyva Elisa , de Loera Denisse , Jimenez‐Catano Rogelio 
Published: October 2010

AbstractThe conversion of substrates (I) into 2‐azido derivatives is followed by spontaneous N2 elimination to form the target compounds.
ChemInform Abstract: Simple and Efficient Procedure for the Synthesis of Novel 1,3‐Diphenyl‐2‐azaphenalene Derivatives via One‐Pot Multicomponent Reactions.
Authors: Foroughifar Naser , Mobinikhaledi Akbar , Moghanian Hassan 
Published: October 2010

AbstractAdvantages of the title procedure is the simplicity of handling and the easy work‐up.
ChemInform Abstract: Regiospecific Synthesis of 6‐Aryl‐3‐cyano‐5‐alkylamino/arylamino‐1‐p‐tolyl‐1H‐pyrazolo [4,3‐d]pyrimidin‐7(6H)‐ones via Iminophosphorane‐Mediated Annulation.
Authors: Wu Ming‐Hu , Hu Ji‐Huan , Shen Dong‐Sheng , Bremond Paul , Guo Haibing 
Published: October 2010

AbstractThe aza‐Wittig reaction of iminophosphorane (III) with aromatic isocyanates to form carbodiimides is followed by the nucleophilic addition of primary or secondary amines to afford the desired fused pyrimidinones (38 examples).
ChemInform Abstract: An Efficient Synthesis of 6,9‐Disubstituted Purin‐8‐ones via Copper‐Catalyzed Coupling/Cyclization.
Authors: Zhong Qi‐Fei , Sun Li‐Ping 
Published: October 2010

AbstractDichloro carbamate (I) undergoes a CuCl/amino acid catalyzed reaction with primary amines to give 6‐chloropurin derivatives (III).
ChemInform Abstract: An Efficient Synthesis of 3,4‐Dihydro‐3‐substituted‐2H‐naphtho[2,1‐e][1,3]oxazine Derivatives Catalyzed by Zirconyl(IV) Chloride and Evaluation of Its Biological Activities.
Authors: Kategaonkar Amol H. , Sonar Swapnil S. , Pokalwar Rajkumar U. , Kategaonkar Atul H. , Shingate Bapurao B. , Shingare Murlidhar S. 
Published: October 2010

AbstractA series of new naphthooxazine derivatives (IV) (9 examples) is synthesized via a novel Zr(IV)‐catalyzed one‐pot, three component reaction of naphthol (I), anilines and formalin.
ChemInform Abstract: Flow‐Vacuum Pyrolysis of Polycyclic Compounds. Part 27. Pyrolysis of 8,9‐Dihydro‐14H‐tetrazolo[1,5‐a]dibenzo[c,f]azonine and 6,7,8,9‐Tetrahydro‐tetrazolo[1,5‐a]benzo[c]azocine.
Authors: Popescu Angela , Andrei Elena , Istrati Daniela , Draghici Constantin , Ciuculescu Crinu , Banciu Mircea D. 
Published: October 2010

AbstractFlow‐vacuum pyrolysis of the title fused tetrazole derivatives (II) and (V), resp., provides stable N‐cyanoheterocycles in good yield.
ChemInform Abstract: H14[NaP5W30O110] as a Heterogeneous Recyclable Catalyst for the Synthesis of 6,8‐Dimethyl‐3‐aryl‐[1,2,4]triazolo[3,4‐b][1,3,4]thiazepine Derivatives.
Authors: Hekmatshoar Rahim , Sadjadi Sodeh , Sadjadi Samaheh , Heravi Majid M. , Bamoharram Fatemeh F. 
Published: October 2010

AbstractThe catalyst can be recycled by filtration and reused.
ChemInform Abstract: Hydroxy‐3,4‐dehydro‐apo‐8′‐lycopene and Methyl Hydroxy‐3,4‐dehydro‐apo‐8′‐lycopenoate, Novel C30 Carotenoids Produced by a Mutant of Marine Bacterium Halobacillus halophilus.
Authors: Osawa Ayako , Ishii Yoko , Sasamura Nao , Morita Marie , Koecher Saskia , Mueller Volker , Sandmann Gerhard , Shindo Kazutoshi 
Published: October 2010

AbstractChemical mutagenesis of Halobacillus leads to the novel carotenoids (I).
ChemInform Abstract: Lactariolines A and B: New Guaiane Sesquiterpenes with a Modulatory Effect on Interferon‐γ Production from the Fruiting Bodies of Lactarius hatsudake.
Authors: Xu Guang‐Hua , Kim Jae Wha , Ryoo In‐Ja , Choo Soo‐Jin , Kim Young‐Hee , Seok Soon‐Ja , Ahn Jong‐Seog , Yoo Ick‐Dong 
Published: October 2010

AbstractThe two new guaiane sesquiterpenes lactarioline A (I) and B (II) inhibit IFN‐γ production in NK92 cells in a dose‐dependent manner.
ChemInform Abstract: Efficient Syntheses of (.+‐.)‐Cherylline and Latifine Dimethyl Ether.
Authors: Kumar A. Sanjeev , Ghosh Samir , Soundararajan R. , Mehta G. N. 
Published: October 2010

AbstractA short and efficient synthesis of racemic cherylline (VIII) and latifine dimethyl ether (XIII) is described.
ChemInform Abstract: A Short Path to Erythrina Alkaloid Derivatives.
Authors: Tuan Le Anh , Kim Guncheol 
Published: October 2010

AbstractThe condensation of (I) with (II) yields (III) and (IV) which can be used as intermediates for the synthesis of erysotramidine precursor (VI) and iso‐13‐demethoxyerythratidinone (IX).
ChemInform Abstract: Stereoselective Preparation of 1‐[5‐O‐(tert‐Butyldimethylsilyl) ‐2,3‐dideoxy‐3‐iodo‐β‐D‐threo‐pentofuranosyl]thymine from Thymidine: An Efficient Entry to 3′,4′‐Unsaturated Nucleoside.
Authors: Kubota Yutaka , Nakamura Kohji , Haraguchi Kazuhiro , Tanaka Hiromichi 
Published: October 2010

AbstractThe title 3′,4′‐unsaturated nucleoside (IV) may be used for the preparation of 4′‐branched derivatives.
ChemInform Abstract: A Stereocontrolled Method for the Synthesis of D‐ and L‐2‐Deoxy‐C‐nucleosides Using an Intramolecular Sakurai‐Type Cyclization Reaction.
Authors: Midtkandal Rebecca R. , Macdonald Simon J. F. , Migaud Marie E. 
Published: October 2010

AbstractTarget compound (V) is prepared by a multistep procedure via cyclization of acetal (II) as a key step.
ChemInform Abstract: The Synthesis of Diverse Adenosine 5′‐Phosphonate Analogues as Chain Terminators Against Hepatitis C Virus (HCV).
Authors: Kim Bo‐Seung , Kim Beom‐Tae , Hwang Ki‐Jun 
Published: October 2010

Abstract4′‐Alkyl or ‐vinyl substituted nucleosides containing azido or amino group at the 2′‐ or 3′‐position [e.g. (VIII)] are conveniently synthesized in good yields.
ChemInform Abstract: A New Pyridyloxadiazole Incorporated Acridone Offering Selective Optical Detection of Fluoride.
Authors: Mashraqui Sabir H. , Tripathi Sapna , Betkar Rupesh , Chandiramani Mukesh 
Published: October 2010

AbstractAcridox‐P (I) offers selective detection of fluoride by means of color change from yellow to orange.
ChemInform Abstract: Synthesis, Characterization and Antimicrobial Studies of 2‐(4‐Methoxy‐phenyl)‐5‐methyl‐4‐(2‐arylsulfanyl‐ethyl)‐2,4‐dihydro‐ [1,2,4]triazolo‐3‐ones and Their Corresponding Sulfones.
Authors: Patil Bhimagouda S. , Krishnamurthy G. , Naik H. S. Bhojya , Latthe Prashant R. , Ghate Manjunath 
Published: October 2010

AbstractCompound (Id) shows good inhibition against S.
ChemInform Abstract: Atom‐Economic Transformations of Propargylic Alcohols Catalyzed by the 16‐Electron Allyl‐ruthenium(II) Complex [Ru(μ3‐2‐C3H4Me)(CO)(dppf)] [SbF6] (dppf = 1,1′‐bis(diphenylphosphino)ferrocene)
Authors: Cadierno Victorio , Garcia‐Garrido Sergio E. , Gimeno Jose , Nebra Noel 
Published: October 2010

AbstractReview: 137 refs.
α‐Chymotrypsin‐Catalyzed Reaction Confined in Block‐Copolymer Vesicles
Authors: Chen Qi , Rausch Kristin G. , Schönherr Holger , Vancso G. Julius 
Published: October 2010

AbstractHerein the reactivity of the enzyme α‐chymotrypsin in the confinement of polystyrene‐block‐poly(acrylic acid) (PS‐b‐PAA) vesicles was investigated. Enzyme and substrate molecules were encapsulated in PS‐b‐PAA vesicles with internal diameters ranging from 26 nm to 165 nm during the formation of the vesicles. While the loading efficiencies of enzyme and substrate molecules were practically identical for vesicles of identical size, they were found to increase with decreasing vesicle size. The kinetics of the α‐chymotrypsin catalyzed hydrolysis of N‐succinyl‐Ala‐Ala‐Phe‐7‐amido‐4‐methylcoumarin (AMC) was evaluated following the increase of the absorption of the product 7‐amino‐4‐methylcoumarin by UV/Vis spectroscopy. The values of the catalytic turnover number obtained for reactions inside vesicles with different sizes showed an increase of up to fourteen times compared to the bulk value with decreasing vesicle volume, while the values of the Michaelis–Menten constant decreased, respectively. This increase in reactivity of α‐chymotrypsin is attributed to the effect of vesicle–wall interactions in the finite encapsulated space, where the reagents could diffuse, leading to enhanced collision frequencies.
Bronchiolitis obliterans organizing pneumonia in renal transplant patients
Authors: Hasni Kamran , Slusher Joseph , Siddiqui Waqar , Matsumura David , Malek Bachar , Heifets Michael , Ahmed Ziauddin 
Published: October 2010

AbstractBronchiolitis obliterans organizing pneumonia (BOOP) is a syndrome with distinct clinical, radiological, and histological features. The radiographic changes of BOOP vary from multiple patchy, alveolar, or ground‐glass infiltrates to diffuse reticulonodular opacities. The most frequently observed CT features are areas of lung consolidation and ground‐glass opacity often with a subpleural distribution and small nodules; in addition, bronchial wall thickening and bronchodilatation can be seen. The exact pathogenesis of BOOP after organ transplantation remains to be clarified. Some researchers have suggested that BOOP is a non‐specific reaction to injury; rejection is the most common injury in lung and kidney transplant recipients.
Three New Polycatenation Networks Based on 4,4′‐Oxybis(benzoate) and Bis(imidazole) Ligands: Synthesis, Structure and Photoluminescence
Authors: Xu Yun , Chen Pang‐Kuan , Che Yun‐Xia , Zheng Ji‐Min 
Published: October 2010

AbstractIn this paper we report three new metal–organic frameworks (MOFs), [Zn(oba)(L1)0.5(H2O)]n (1), [Zn2(oba)2(L2)2](H2O)3 (2) and [Co(oba)(L1)]n (3) [oba = 4,4′‐oxybis(benzoate), L1 = 1,4‐bis(imidazol‐1‐ylmethyl)benzene, L2 = 1,4‐bis(imidazol‐1‐yl)benzene] that have been obtained under hydrothermal conditions and characterized by single‐crystal X‐ray diffraction, powder X‐ray diffraction (PXRD), infrared spectroscopy (IR), thermogravimetric analysis (TGA) and elemental analysis (EA). A structural investigation revealed that all three coordination compounds present polycatenation features. Interestingly, 1 shows a rare 1D → 2D structure formed by the catenation of 1D ladders. Both 2 and 3, however, are unusual cases that have 3D frameworks constructed from 2D 44‐sql layers by parallel polycatenation. The photoluminescence properties of 1 and 2 have also been investigated.
Physicochemical and textural properties of puff pastry margarines
Authors: Pajin Biljana , Šoronja‐Simović Dragana , Šereš Zita , Gyura Julianna , Radujko Ivana , Sakač Marijana 
Published: October 2010

AbstractIn this paper some physicochemical and textural characteristics of four puff pastry margarines are defined: MLT1 and MLT2 with low trans fatty acid (TFA) content, MLT3 with relatively low and MLT4 with high TFA content. Analyzing the solid trigliceride content (SFC), the crystallization kinetics in isothermal conditions and the margarine firmness, it is determined whether the technological characteristics of margarines (which are very important for puff pastry quality) are significantly changed due to TFA decrease in margarines. The highest SFC at 10, 20, 25 i 30°C have samples MLT1 and MLT4. Despite of significant differences in fatty acid composition of these margarines, SFC content at temperatures at 20, 25, and 30°C do not differ significantly, at the level of significance of 95% (p>0.05). The SFC of MLT1 and MLT2 samples, which have practically the same fatty acid composition at every investigated temperature, statistically have significant difference (p<0.05). The crystallization kinetics are in the range from 2.6 to 10.1% per min. The significance of the induction period at every observed samples is negligible. The average firmness of margarine samples MLT1, MLT2, MLT3, and MLT4 at 20, 25, and 30°C is significantly different (p<0.05). The firmness changes of the samples MLT1 and MLT2 in the most important temperature interval for puff pastry production (between 20 and 30°C) are at level of 5 to 25%, and for margarine samples MLT3 and MLT4 these values reach even 70%.
A constitutive expression system for high‐throughput screening
Authors: Aerts Dirk , Verhaeghe Tom , De Mey Marjan , Desmet Tom , Soetaert Wim 
Published: October 2010

AbstractTo reduce the amount of consumables and number of pipetting steps in high‐throughput screening, a constitutive expression system was developed that comprises four different promoters of varying strength. The system was validated by the expression of different sucrose phosphorylase enzymes from Leuconostoc mesenteroides, Lactobacillus acidophilus and Bifidobacterium adolescentis in 96‐deep‐ and low‐well plates at three temperatures. Drastically improved soluble expression in mini‐cultures was observed for the enzymes from L. mesenteroides strains by reducing the promoter strength from strong to intermediate and by expressing the proteins at lower temperatures. In contrast, the enzymes from B. adolescentis and L. acidophilus were expressed most efficiently with a strong promoter. The constitutive expression of sucrose phosphorylases in low‐well plates resulted in a level of activity that is equal or even better than what was achieved by inducible expression. Therefore, our plasmid set with varying constitutive promoters will be an indispensable tool to optimize enzyme expression for high‐throughput screening.
Powerful multi‐marker association tests: unifying genomic distance‐based regression and logistic regression
Authors: Han Fang , Pan Wei 
Published: October 2010

AbstractTo detect genetic association with common and complex diseases, many statistical tests have been proposed for candidate gene or genome‐wide association studies with the case‐control design. Due to linkage disequilibrium (LD), multi‐marker association tests can gain power over single‐marker tests with a Bonferroni multiple testing adjustment. Among many existing multi‐marker association tests, most target to detect only one of many possible aspects in distributional differences between the genotypes of cases and controls, such as allele frequency differences, while a few new ones aim to target two or three aspects, all of which can be implemented in logistic regression. In contrast to logistic regression, a genomic distance‐based regression (GDBR) approach aims to detect some high‐order genotypic differences between cases and controls. A recent study has confirmed the high power of GDBR tests. At this moment, the popular logistic regression and the emerging GDBR approaches are completely unrelated; for example, one has to choose between the two. In this article, we reformulate GDBR as logistic regression, opening a venue to constructing other powerful tests while overcoming some limitations of GDBR. For example, asymptotic distributions can replace time‐consuming permutations for deriving P‐values and covariates, including gene‐gene interactions, can be easily incorporated. Importantly, this reformulation facilitates combining GDBR with other existing methods in a unified framework of logistic regression. In particular, we show that Fisher's P‐value combining method can boost statistical power by incorporating information from allele frequencies, Hardy–Weinberg disequilibrium, LD patterns, and other higher‐order interactions among multi‐markers as captured by GDBR. Genet. Epidemiol. 34:680–688, 2010. © 2010 Wiley‐Liss, Inc.