bluuebunny/crossref_metadata_2025_split huggingface dataset:
Common Molecular Cytogenetic Pathway in Papillary Tumors of the Pineal Region (PTPR)
Authors: Gutenberg Angelika , Brandis Almuth , Hong Bujung , Gunawan Bastian , Enders Christina , Schaefer Inga‐Marie , Burger Ralf , Ostertag Helmut , Gaab Michael , Krauss Joachim K. , Füzesi Laszlo 
Published: April 2011

AbstractPrimary papillary tumors of the central nervous system and particularly the pineal region are rare. Papillary tumor of the pineal region (PTPR) is a recently described neoplasm that has been formally recognized in the 2007 World Health Organization Classification of Tumors of the Nervous System. Because of their rarity, further pheno‐ and genotypical observations as well as therapeutic experience are necessary to differentiate PTPR from other primary or secondary papillary tumors of this region. We herein present three cases of PTPR characterized by local recurrence in two of them. Primary and recurrent tumors were analyzed by immunohistochemistry and comparative genomic hybridization (CGH). From our results clonal chromosomal aberrations can be postulated which seem to be a feasible tool to differentiate PTPRs from other primary or secondary papillary tumors of this region.
FINITE SELF-SIMILAR p-GROUPS WITH ABELIAN FIRST LEVEL STABILIZERS
Authors: ŠUNIĆ ZORAN 
Published: April 2011

We determine all finite p-groups that admit a faithful, self-similar action on the p-ary rooted tree such that the first level stabilizer is abelian. A group is in this class if and only if it is a split extension of an elementary abelian p-group by a cyclic group of order p.The proof is based on use of virtual endomorphisms. In this context the result says that if G is a finite p-group with abelian subgroup H of index p, then there exists a virtual endomorphism of G with trivial core and domain H if and only if G is a split extension of H and H is an elementary abelian p-group.
Expression of Id-1 Is Regulated by MCAM/MUC18: A Missing Link in Melanoma Progression
Authors: Zigler Maya , Villares Gabriel J. , Dobroff Andrey S. , Wang Hua , Huang Li , Braeuer Russell R. , Kamiya Takafumi , Melnikova Vladislava O. , Song Renduo , Friedman Ran , Alani Rhoda M. , Bar-Eli Menashe 
Published: April 2011

Abstract
The acquisition of the metastatic melanoma phenotype is associated with increased expression of the melanoma cell adhesion molecule MCAM/MUC18 (CD146). However, the mechanism by which MUC18 contributes to melanoma metastasis remains unclear. Herein, we stably silenced MUC18 expression in two metastatic melanoma cell lines, A375SM and C8161, and conducted cDNA microarray analysis. We identified and validated that the transcriptional regulator, inhibitor of DNA binding-1 (Id-1), previously shown to function as an oncogene in several malignancies, including melanoma, was downregulated by 5.6-fold following MUC18 silencing. Additionally, we found that MUC18 regulated Id-1 expression at the transcriptional level via ATF-3, which itself was upregulated by 6.9-fold in our cDNA microarray analysis. ChIP analysis showed increased binding of ATF-3 to the Id-1 promoter after MUC18 silencing. To complement these studies, we rescued the expression of MUC18, which reversed the expression patterns of Id-1 and ATF-3. Moreover, we showed that MUC18 promotes melanoma invasion through Id-1, as overexpression of Id-1 in MUC18-silenced cells resulted in increased MMP-2 expression and activity. To our knowledge, this is the first demonstration that MUC18 is involved in cell signaling regulating the expression of Id-1 and ATF-3, thus contributing to melanoma metastasis. Cancer Res; 71(10); 3494–504. ©2011 AACR.
Increased Survival following Tumorigenesis in Ts65Dn Mice That Model Down Syndrome
Authors: Yang Annan , Reeves Roger H. 
Published: April 2011

Abstract
Epidemiologic results tend to suggest that adults with Down syndrome have a reduced incidence of cancer, but some studies have reached the opposite conclusion. In this study, we offer direct biological evidence in support of the notion that Down syndrome reduces incidence of multiple types of cancer. Previous studies showed that introduction of the ApcMin mutation into the Ts65Dn mouse model of Down syndrome by interbreeding caused formation of intestinal adenomas at a significantly reduced incidence compared with control (euploid) animals that did not have trisomy. To a large degree, this reduction was determined to reflect an increased dosage of the Ets2 tumor repressor gene due to trisomy. Studies of tumor grafts using Ts65Dn suggested angiogenesis as a mechanism that mediated reduced tumor growth, metastasis, and mortality in individuals with Down syndrome. To confirm and extend these findings, we employed the complex cancer mouse model NPcis, which is heterozygous for the Trp53 and Nf1 genes and through LOH develops lymphomas, sarcomas, or carcinomas with 100% penetrance. In this aggressive model, trisomy did not prevent cancer, but it nevertheless extended host survival relative to euploid littermates. However, protection in this case was not attributable to either Ets2 dosage or to reduced angiogenesis. Together, our findings indicate that the genetic complexity underlying Down syndrome supports multiple mechanisms that contribute to reduced mortality from cancer. Cancer Res; 71(10); 3573–81. ©2011 AACR.
The Understanding Severe Thunderstorms and Alberta Boundary Layers Experiment (UNSTABLE) 2008
Authors: Taylor Neil M. , Sills David M. L. , Hanesiak John M. , Milbrandt Jason A. , Smith Craig D. , Strong Geoff S. , Skone Susan H. , McCarthy Patrick J. , Brimelow Julian C. 
Published: April 2011

Severe thunderstorms are a common occurrence in summer on the Canadian prairies, with a large number originating along the Alberta, Canada, foothills, just east of the Rocky Mountains. Most of these storms move eastward to affect the Edmonton–Calgary corridor, one of the most densely populated and fastest-growing regions in Canada. Previous studies in the United States, Europe, and Canada have stressed the importance of mesoscale features in thunderstorm development. However, such processes cannot be adequately resolved using operational observation networks in many parts of Canada. Current conceptual models for severe storm outbreaks in Alberta were developed almost 20 years ago and do not focus explicitly on mesoscale boundaries that are now known to be important for thunderstorm development.
The Understanding Severe Thunderstorms and Alber ta Boundary Layers Experiment (UNSTABLE) is a field and modeling study aiming to improve our understanding of the processes associated with the initiation of severe thunderstorms, to refine associated conceptual models, and to assess the ability of convectivescale NWP models to simulate relevant physical processes. As part of UNSTABLE in 2008, Environment Canada and university scientists conducted a pilot field experiment over the Alberta foothills to investigate mesoscale processes associated with the development of severe thunderstorms. Networks of fixed and mobile surface and upper-air instrumentation provided observations of the atmospheric boundary layer at a level of detail never before seen in this region. Preliminary results include the most complete documentation of a dryline in Canada and an analysis of variability in boundary layer evolution across adjacent forest and crop vegetation areas. Convective-scale NWP simulations suggest that although additional information on convective mode may be provided, there is limited benefit overall to downscaling to smaller grid spacing without assimilation of mesoscale observations.
Automatic classification of sentences to support Evidence Based Medicine
Authors: Kim Su Nam , Martinez David , Cavedon Lawrence , Yencken Lars 
Published: April 2011

AbstractAimGiven a set of pre-defined medical categories used in Evidence Based Medicine, we aim to automatically annotate sentences in medical abstracts with these labels.MethodWe constructed a corpus of 1,000 medical abstracts annotated by hand with specified medical categories (e.g.Intervention,Outcome). We explored the use of various features based on lexical, semantic, structural, and sequential information in the data, using Conditional Random Fields (CRF) for classification.ResultsFor the classification tasks over all labels, our systems achieved micro-averaged f-scores of 80.9% and 66.9% over datasets of structured and unstructured abstracts respectively, using sequential features. In labeling only the key sentences, our systems produced f-scores of 89.3% and 74.0% over structured and unstructured abstracts respectively, using the same sequential features. The results over an external dataset were lower (f-scores of 63.1% for all labels, and 83.8% for key sentences).ConclusionsOf the features we used, the best for classifying any given sentence in an abstract were based on unigrams, section headings, and sequential information from preceding sentences. These features resulted in improved performance over a simple bag-of-words approach, and outperformed feature sets used in previous work.
Low bone mineral density is a significant risk factor for low-energy distal radius fractures in middle-aged and elderly men: A case-control study
Authors: Øyen Jannike , Rohde Gudrun , Hochberg Marc , Johnsen Villy , Haugeberg Glenn 
Published: April 2011

Abstract

Background
In general there is a lack of data on osteoporosis and fracture in men; this also includes low-energy distal radius fractures. The objectives of this study were to examine BMD and identify factors associated with distal radius fractures in male patients compared with controls recruited from the background population.

Methods
In a 2-year period, 44 men 50 years or older were diagnosed with low-energy distal radius fractures, all recruited from one hospital. The 31 men who attended for osteoporosis assessment were age-matched with 35 controls. Demographic and clinical data were collected and BMD at femoral neck, total hip and spine L2-4 was assessed by dual energy X-ray absorptiometry.

Results
Apart from weight and living alone, no significant differences were found between patient and controls for demographic variables (e.g. height, smoking) and clinical variables (e.g. co-morbidity, use of glucocorticoids, osteoporosis treatment, falls and previous history of fracture). However, BMD expressed as T-score was significant lower in patients than in controls at all measurement sites (femoral neck: -2.24 vs. -1.15, p < 0.001; Total hip: -1.65 vs. -0.64, p < 0.001; Spine L2-4: -1.26 vs. 0.25, p = 0.002). Among the potential risk factors for fracture evaluated, only reduced BMD was found to be significantly associated with increased risk for low-energy distal radius fractures in men.

Conclusion
The results from our study indicate that reduced BMD is an important risk factor for low-energy distal radius fracture in men. This suggests that improvement of BMD by both pharmacological and non-pharmacological initiatives may be a strategy to reduce fracture risk in men.
GH10 xylanase D from Penicillium funiculosum: biochemical studies and xylooligosaccharide production
Authors: Lafond Mickael , Tauzin Alexandra , Desseaux Véronique , Bonnin Estelle , Ajandouz El-Hassan , Giardina Thierry 
Published: April 2011

Abstract

Background
The filamentous fungus Penicillium funiculosum produces a range of glycoside hydrolases (GH). The XynD gene, encoding the sole P. funiculosum GH10 xylanase described so far, was cloned into the pPICZαA vector and expressed in methylotrophe yeast Pichia pastoris, in order to compare the results obtained with the P. funiculosum GH11 xylanases data.

Results
High level expression of recombinant XynD was obtained with a secretion of around 60 mg.L-1. The protein was purified to homogeneity using one purification step. The apparent size on SDS-PAGE was around 64 kDa and was 46 kDa by mass spectrometry thus higher than the expected molecular mass of 41 kDa. The recombinant protein was N- and O-glycosylated, as demonstrated using glycoprotein staining and deglycosylation reactions, which explained the discrepancy in molecular mass. Enzyme-catalysed hydrolysis of low viscosity arabinoxylan (LVAX) was maximal at pH 5.0 with K m(app) and k

cat
/K m(app) of 3.7 ± 0.2 (mg.mL-1) and 132 (s-1mg-1.mL), respectively. The activity of XynD was optimal at 80°C and the recombinant enzyme has shown an interesting high thermal stability at 70°C for at least 180 min without loss of activity. The enzyme had an endo-mode of action on xylan forming mainly xylobiose and short-chain xylooligosaccharides (XOS). The initial rate data from the hydrolysis of short XOS indicated that the catalytic efficiency increased slightly with increasing their chain length with a small difference of the XynD catalytic efficiency against the different XOS.

Conclusion
Because of its attractive properties XynD might be considered for biotechnological applications. Moreover, XOS hydrolysis suggested that XynD possess four catalytic subsites with a high energy of interaction with the substrate and a fifth subsite with a small energy of interaction, according to the GH10 xylanase literature data.
Thermal conductivity and viscosity of self-assembled alcohol/polyalphaolefin nanoemulsion fluids
Authors: Xu Jiajun , Yang Bao , Hammouda Boualem 
Published: April 2011

AbstractVery large thermal conductivity enhancement had been reported earlier in colloidal suspensions of solid nanoparticles (i.e., nanofluids) and more recently also in oil-in-water emulsions. In this study, nanoemulsions of alcohol and polyalphaolefin (PAO) are spontaneously generated by self-assembly, and their thermal conductivity and viscosity are investigated experimentally. Alcohol and PAO have similar thermal conductivity values, so that the abnormal effects, such as particle Brownian motion, on thermal transport could be deducted in these alcohol/PAO nanoemulsion fluids. Small angle neutron-scattering measurement shows that the alcohol droplets are spheres of 0.8-nm radius in these nanoemulsion fluids. Both thermal conductivity and dynamic viscosity of the fluids are found to increase with alcohol droplet loading, as expected from classical theories. However, the measured conductivity increase is very moderate, e.g., a 2.3% increase for 9 vol%, in these fluids. This suggests that no anomalous enhancement of thermal conductivity is observed in the alcohol/PAO nanoemulsion fluids tested in this study.
Fabrication and magnetic properties of granular Co/porous InP nanocomposite materials
Authors: Zhou Tao , Cheng Dandan , Zheng Maojun , Ma Li , Shen Wenzhong 
Published: April 2011

AbstractA novel Co/InP magnetic semiconductor nanocomposite was fabricated by electrodeposition magnetic Co nanoparticles into n-type porous InP templates in ethanol solution of cobalt chloride. The content or particle size of Co particles embedded in porous InP increased with increasing deposition time. Co particles had uniform distribution over pore sidewall surface of InP template, which was different from that of ceramic template and may open up new branch of fabrication of nanocomposites. The magnetism of such Co/InP nanocomposites can be gradually tuned from diamagnetism to ferromagnetism by increasing the deposition time of Co. Magnetic anisotropy of this Co/InP nanocomposite with magnetization easy axis along the axis of InP square channel was well realized by the competition between shape anisotropy and magnetocrystalline anisotropy. Such Co/InP nanocomposites with adjustable magnetism may have potential applications in future in the field of spin electronics.PACS: 61.46. +w · 72.80.Tm · 81.05.Rm · 75.75. +a · 82.45.Aa
Enhanced plasmonic behavior of bimetallic (Ag-Au) multilayered spheres
Authors: Peña-Rodríguez Ovidio , Pal Umapada 
Published: April 2011

AbstractIn this article we study the plasmonic behavior of some stable, highly biocompatible bimetallic metal-dielectric-metal (MDM) and double concentric nanoshell (DCN) structures. By simply switching the material of the inner structure from Au to Ag, the intensity of their surface plasmon resonance could be increased in the optical transparency region of the human tissues up to 20 and 60 percent for the MDM and DCN, respectively, while the biocompatibility is retained. The obtained results indicate that these novel structures could be highly suitable for surface enhanced Raman scattering and photothermal cancer therapy.
Measurement of local two-phase flow parameters of nanofluids using conductivity double-sensor probe
Authors: Park Yu Sun , Chang Soon Heung 
Published: April 2011

AbstractA two-phase flow experiment using air and water-based γ-Al2O3 nanofluid was conducted to observe the basic hydraulic phenomenon of nanofluids. The local two-phase flow parameters were measured with a conductivity double-sensor two-phase void meter. The void fraction, interfacial velocity, interfacial area concentration, and mean bubble diameter were evaluated, and all of those results using the nanofluid were compared with the corresponding results for pure water. The void fraction distribution was flattened in the nanofluid case more than it was in the pure water case. The higher interfacial area concentration resulted in a smaller mean bubble diameter in the case of the nanofluid. This was the first attempt to measure the local two-phase flow parameters of nanofluids using a conductivity double-sensor two-phase void meter. Throughout this experimental study, the differences in the internal two-phase flow structure of the nanofluid were identified. In addition, the heat transfer enhancement of the nanofluid can be resulted from the increase of the interfacial area concentration which means the available area of the heat and mass transfer.
Seroprevalence of Toxoplasma gondii infection in dairy goats in Shaanxi Province, Northwestern China
Authors: Zhao Guang-Hui , Zhang Miao-Tao , Lei Li-Hui , Shang Chuan-Chuan , Cao Duo-Yao , Tian Ting-Ting , Li Jie , Xu Jun-Yan , Yao Yun-liang , Chen De-Kun , Zhu Xing-Quan 
Published: April 2011

Abstract

Background

Toxoplasma gondii is an important zoonotic pathogen causing significant human and animal health problems. Infection in dairy goats not only results in significant reproductive losses, but also represents an important source of human infection due to consumption of infected meat and milk. In the present study we report for the first time seroprevalence of T. gondii infection in Guanzhong and Saanen dairy goats in Shaanxi province, Northwestern China.

Results
Sera from 751 dairy goats from 9 farms in 6 counties were examined for T. gondii antibodies with an indirect haemagglutination (IHA) test. Antibodies to T. gondii were detected in 106 (14.1%) serum samples, with antibody titres ranging from 1:64 to 1:1024. Seropositive goats were found in all 9 farms and seroprevalences in Guanzhong (16.3%, 75/461) and Saanen (10.7%, 31/290) dairy goats were not statistically significantly different. All the factors (sex, age and location) reported in the present study affected prevalence of infection, and seroprevalence increased with age, suggesting postnatal acquisition of T. gondii infection.

Conclusions
The results of the present survey indicate that infection by T. gondii is widely prevalent in dairy goats in Shaanxi province, Northwestern China, and this has implications for prevention and control of toxoplasmosis in this province.
Continuous and low-energy 125I seed irradiation changes DNA methyltransferases expression patterns and inhibits pancreatic cancer tumor growth
Authors: Ma Jian-xia , Jin Zhen-dong , Si Pei-ren , Liu Yan , Lu Zheng , Wu Hong-yu , Pan Xue , Wang Luo-wei , Gong Yan-fang , Gao Jun , Zhao-shen Li 
Published: April 2011

AbstractBackgroundIodine 125 (125I) seed irradiation is an effective treatment for unresectable pancreatic cancers. However, the radiobiological mechanisms underlying brachytherapy remain unclear. Therefore, we investigated the influence of continuous and low-energy125I irradiation on apoptosis, expression of DNA methyltransferases (DNMTs) and cell growth in pancreatic cancers.Materials and methodsForin vitro125I seed irradiation, SW-1990 cells were divided into three groups: control (0 Gy), 2 Gy, and 4 Gy. To create an animal model of pancreatic cancer, the SW 1990 cells were surgically implanted into the mouse pancreas. At 10 d post-implantation, the 30 mice with pancreatic cancer underwent125I seed implantation and were separated into three groups: 0 Gy, 2 Gy, and 4 Gy group. At 48 or 72 h after irradiation, apoptosis was detected by flow cytometry; changes in DNMTs mRNA and protein expression were assessed by real-time PCR and western blotting analysis, respectively. At 28 d after125I seed implantation,in vivoapoptosis was evaluated with TUNEL staining, while DNMTs protein expression was detected with immunohistochemical staining. The tumor volume was measured 0 and 28 d after125I seed implantation.Results125I seed irradiation induced significant apoptosis, especially at 4 Gy. DNMT1 and DNMT3b mRNA and protein expression were substantially higher in the 2 Gy group than in the control group. Conversely, the 4 Gy cell group exhibited significantly decreased DNMT3b mRNA and protein expression relative to the control group. There were substantially more TUNEL positive in the125I seed implantation treatment group than in the control group, especially at 4 Gy. The 4 Gy seed implantation group showed weaker staining for DNMT1 and DNMT3b protein relative to the control group. Consequently,125I seed implantation inhibited cancer growth and reduced cancer volume.Conclusion125I seed implantation kills pancreatic cancer cells, especially at 4 Gy.125I-induced apoptosis and changes in DNMT1 and DNMT3b expression suggest potential mechanisms underlying effective brachytherapy.
A HACCP-based approach to mastitis control in dairy herds. Part 1: Development
Authors: Beekhuis-Gibbon Lies , Whyte Paul , O'Grady Luke , More Simon J , Doherty Michael L 
Published: April 2011

AbstractHazard Analysis and Critical Control Points (HACCP) systems are a risk based preventive approach developed to increase levels of food safety assurance. This is part 1 of a pilot study on the development, implementation and evaluation of a HACCP-based approach for the control of good udder health in dairy cows. The paper describes the use of a novel approach based on a deconstruction of the infectious process in mastitis to identify Critical Control Points (CCPs) and develop a HACCP-based system to prevent and control mastitis in dairy herds. The approach involved the creation of an Infectious Process Flow Diagram, which was then cross-referenced to two production process flow diagrams of the milking process and cow management cycle. The HACCP plan developed, may be suitable for customisation and implementation on dairy farms. This is a logical, systematic approach to the development of a mastitis control programme that could be used as a template for the development of control programmes for other infectious diseases in the dairy herd.