bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two MHC Class I Molecules Associated with Elite Control of Immunodeficiency Virus Replication, Mamu-B*08 and HLA-B*2705, Bind Peptides with Sequence Similarity
Authors: Loffredo John T. , Sidney John , Bean Alex T. , Beal Dominic R. , Bardet Wilfried , Wahl Angela , Hawkins Oriana E. , Piaskowski Shari , Wilson Nancy A. , Hildebrand William H. , Watkins David I. , Sette Alessandro 
Published: June 2009

Abstract
HLA-B27- and -B57-positive HIV-infected humans have long been associated with control of HIV replication, implying that CD8+ T cell responses contribute to control of viral replication. In a similar fashion, 50% of Mamu-B*08-positive Indian rhesus macaques control SIVmac239 replication and become elite controllers with chronic-phase viremia &lt;1000 viral RNA copies/ml. Interestingly, Mamu-B*08-restricted SIV-derived epitopes appeared to match the peptide binding profile for HLA-B*2705 in humans. We therefore defined a detailed peptide-binding motif for Mamu-B*08 and investigated binding similarities between the macaque and human MHC class I molecules. Analysis of a panel of ∼900 peptides revealed that despite substantial sequence differences between Mamu-B*08 and HLA-B*2705, the peptide-binding repertoires of these two MHC class I molecules share a remarkable degree of overlap. Detailed knowledge of the Mamu-B*08 peptide-binding motif enabled us to identify six additional novel Mamu-B*08-restricted SIV-specific CD8+ T cell immune responses directed against epitopes in Gag, Vpr, and Env. All 13 Mamu-B*08-restricted epitopes contain an R at the position 2 primary anchor and 10 also possess either R or K at the N terminus. Such dibasic peptides are less prone to cellular degradation. This work highlights the relevance of the Mamu-B*08-positive SIV-infected Indian rhesus macaque as a model to examine elite control of immunodeficiency virus replication. The remarkable similarity of the peptide-binding motifs and repertoires for Mamu-B*08 and HLA-B*2705 suggests that the nature of the peptide bound by the MHC class I molecule may play an important role in control of immunodeficiency virus replication.
The Development and Function of Regulatory B Cells Expressing IL-10 (B10 Cells) Requires Antigen Receptor Diversity and TLR Signals
Authors: Yanaba Koichi , Bouaziz Jean-David , Matsushita Takashi , Tsubata Takeshi , Tedder Thomas F. 
Published: June 2009

Abstract
Autoimmunity and inflammation are controlled in part by regulatory B cells, including a recently identified IL-10-competent CD1dhighCD5+ B cell subset termed B10 cells that represents 1–3% of adult mouse spleen B cells. In this study, pathways that influence B10 cell generation and IL-10 production were identified and compared with previously described regulatory B cells. IL-10-competent B cells were predominantly CD1dhighCD5+ in adult spleen and were the prevalent source of IL-10, but not other cytokines. B10 cell development and/or maturation in vivo required Ag receptor diversity and intact signaling pathways, but not T cells, gut-associated flora, or environmental pathogens. Spleen B10 cell frequencies were significantly expanded in aged mice and mice predisposed to autoimmunity, but were significantly decreased in mouse strains that are susceptible to exogenous autoantigen-induced autoimmunity. LPS, PMA, plus ionomycin stimulation in vitro for 5 h induced B10 cells to express cytoplasmic IL-10. However, prolonged LPS or CD40 stimulation (48 h) induced additional adult spleen CD1dhighCD5+ B cells to express IL-10 following PMA plus ionomycin stimulation. Prolonged LPS or CD40 stimulation of newborn spleen and adult blood or lymph node CD1dlow and/or CD5− B cells also induced cytoplasmic IL-10 competence in rare B cells, with CD40 ligation uniformly inducing CD5 expression. IL-10 secretion was induced by LPS signaling through MyD88-dependent pathways, but not following CD40 ligation. LPS stimulation also induced rapid B10 cell clonal expansion when compared with other spleen B cells. Thereby, both adaptive and innate signals regulate B10 cell development, maturation, CD5 expression, and competence for IL-10 production.
Culling of Activated CD4 T Cells during Typhoid Is Driven by Salmonella Virulence Genes
Authors: Srinivasan Aparna , Nanton Minelva , Griffin Amanda , McSorley Stephen J. 
Published: June 2009

Abstract
Pathogen-specific CD4 T cells are activated within a few hours of oral Salmonella infection and are essential for protective immunity. However, CD4 T cells do not participate in bacterial clearance until several weeks after infection, suggesting that Salmonella can inhibit or evade CD4 T cells that are activated at early time points. Here, we describe the progressive culling of initially activated CD4 T cells in Salmonella-infected mice. Loss of activated CD4 T cells was independent of early instructional programming, T cell precursor frequency, and Ag availability. In contrast, apoptosis of Ag-specific CD4 T cells was actively induced by live bacteria in a process that required Salmonella pathogenicity island-2 and correlated with increased expression of PD-L1. These data demonstrate efficient culling of initially activated Ag-specific CD4 cells by a microbial pathogen and document a novel strategy for bacterial immune evasion.
Cutting Edge: γδ Intraepithelial Lymphocytes of the Small Intestine Are Not Biased toward Thymic Antigens
Authors: Jensen Kirk D. C. , Shin Sunny , Chien Yueh-hsiu 
Published: June 2009

Abstract
γδ Τ cells, together with αβ Τ cells, are abundantly present in the epithelial layer of the small intestine (IEL) and are essential for the host’s first line of defense. Whether or not γδ IELs, like αβ IELs, are derived from thymocytes that encounter self-Ags in the thymus is unclear. In this study, we report that a natural population of γδ T cells that are specific for the nonclassical MHC class I molecules T10 and T22 are present in the IEL compartment of mice that do not express T10/T22. Furthermore, the small intestinal homing receptor CCR9 is preferentially expressed on γδ thymocytes that have yet to encounter a ligand, and γδ thymocytes with high affinity for self-ligand are CCR9low. These observations suggest that the Ag-specific repertoire of γδ IELs is not biased toward thymic Ags. Instead, γδ IELs appear suited to respond to novel Ags revealed in pathological settings.
Enhanced Airway Inflammation and Remodeling in Adenosine Deaminase-Deficient Mice Lacking the A2B Adenosine Receptor
Authors: Zhou Yang , Mohsenin Amir , Morschl Eva , Young Hays W. J. , Molina Jose G. , Ma Wenbin , Sun Chun-Xiao , Martinez-Valdez Hector , Blackburn Michael R. 
Published: June 2009

AbstractAdenosine is a signaling nucleoside that is generated in response to cellular injury and orchestrates the balance between tissue protection and the progression to pathological tissue remodeling. Adenosine deaminase (ADA)-deficient mice develop progressive airway inflammation and remodeling in association with adenosine elevations, suggesting that adenosine can promote features of chronic lung disease. Furthermore, pharmacological studies in ADA-deficient mice demonstrate that A2BR antagonism can attenuate features of chronic lung disease, implicating this receptor in the progression of chronic lung disease. This study examines the contribution of A2BR signaling in this model by generating ADA/A2BR double-knockout mice. Our hypothesis was that genetic removal of the A2BR from ADA-deficient mice would lead to diminished pulmonary inflammation and damage. Unexpectedly, ADA/A2BR double-knockout mice exhibited enhanced pulmonary inflammation and airway destruction. Marked loss of pulmonary barrier function and excessive airway neutrophilia are thought to contribute to the enhanced tissue damage observed. These findings support an important protective role for A2BR signaling during acute stages of lung disease.
Genome-Wide Identification of Long Noncoding RNAs in CD8+ T Cells
Authors: Pang Ken C. , Dinger Marcel E. , Mercer Tim R. , Malquori Lorenzo , Grimmond Sean M. , Chen Weisan , Mattick John S. 
Published: June 2009

Abstract
Previous research into the molecular mechanisms that underlie Ag-specific CD8+ T cell differentiation and function has largely focused on the role of proteins. However, it is now apparent that the mammalian genome expresses large numbers of long (&gt;200 nt) nonprotein-coding RNAs (ncRNAs), and there is increasing evidence that these RNAs have important regulatory functions, particularly in the regulation of epigenetic processes underpinning cell differentiation. In this study, we show that CD8+ T cells express hundreds of long ncRNAs, many of which are lymphoid-specific and/or change dynamically with lymphocyte differentiation or activation. Numerous ncRNAs surround or overlap immunologically important protein-coding genes and can be predicted to function via a range of regulatory mechanisms. The overlap of many long ncRNAs expressed in CD8+ T cells with microRNAs and small interfering RNAs further suggests that long ncRNAs may be processed into and exert their effects via smaller functional species. Finally, we show that the majority of long ncRNAs expressed in CD8+ T cells harbor signatures of evolutionary conservation, secondary structures, and/or regulated promoters, further supporting their functionality. Taken together, our findings represent the first systematic discovery of long ncRNAs expressed in CD8+ T cells and suggest that many of these transcripts are likely to play a role in adaptive immunity.
Analogous Interactions in Initiating Complexes of the Classical and Lectin Pathways of Complement
Authors: Phillips Anna E. , Toth Julia , Dodds Alister W. , Girija Umakhanth Venkatraman , Furze Christopher M. , Pala Eleni , Sim Robert B. , Reid Kenneth B. M. , Schwaeble Wilhelm J. , Schmid Ralf , Keeble Anthony H. , Wallis Russell 
Published: June 2009

Abstract
The classical and lectin pathways of complement activation neutralize pathogens and stimulate key immunological processes. Both pathways are initiated by collagen-containing, soluble pattern recognition molecules associated with specific serine proteases. In the classical pathway, C1q binds to Ab-Ag complexes or bacterial surfaces to activate C1r and C1s. In the lectin pathway, mannan-binding lectin and ficolins bind to carbohydrates on pathogens to activate mannan-binding lectin-associated serine protease 2. To characterize the interactions leading to classical pathway activation, we have analyzed binding between human C1q, C1r, and C1s, which associate to form C1, using full-length and truncated protease components. We show that C1r and C1s bind to C1q independently. The CUB1-epidermal growth factor fragments contribute most toward binding, but CUB2 of C1r, but not of C1s, is also important. Each C1rs tetramer presents a total of six binding sites, one for each of the collagenous domains of C1q. We also demonstrate that subcomponents of the lectin and classical pathways cross-interact. Thus, although the stoichiometries of complexes differ, interactions are analogous, with equivalent contacts between recognition and protease subcomponents. Importantly, these new data are contrary to existing models of C1 and enable us to propose a new model using mannan-binding lectin-mannan-binding lectin-associated serine protease interactions as a template.
La fabrique de l’événement littéraire : l’exemple de La Vie mode d’emploi
Authors: Bertelli Dominique 
Published: June 2009

Résumé Récusant toute définition de l’œuvre comme une essence donnée une fois pour toutes, la recherche présentée dans cet article participe à l’analyse de la production de la valeur littéraire à partir de l’identification de quelques dimensions de ce qui fait un événement littéraire. Loin d’opposer l’espace littéraire et l’espace médiatique, l’auteur analyse la façon dont se tissent ces deux modalités d’invention du fait littéraire, à partir des stratégies auctoriales et éditoriales, ainsi que des médiations opérées par la collection, les formes de l’œuvre, le processus de parution, la construction de la figure auctoriale. L’analyse porte sur le roman de Georges Perec La vie mode d’emploi . Cf. sur ce sujet « La valeur de la médiation littéraire », Communication & langages , n° 150, 2006.
Contraceptive Method Use Among a Population-Based Cohort During the South Carolina Choose Well Initiative
Authors: Hale Nathan , Lee Jusung , de Jong Jordan , Smith Michael G. , Khoury Amal J. 
Published: April 2024

ImportanceEvaluating the impact of statewide contraceptive access initiatives is necessary for informing health policy and practice.ObjectiveTo examine changes in contraceptive method use among a cohort of women of reproductive age in South Carolina during the Choose Well contraceptive access initiative.Design, Setting, and ParticipantsIn this cohort study, baseline data from the initial Statewide Survey of Women administered from October 1, 2017, to April 30, 2018, to a probability-based sample of women of reproductive age in South Carolina and a peer state (Alabama) were linked with 3 follow-up surveys given in 2019, 2020, and 2021. Responses about contraception use from the initial survey were compared with responses across follow-up surveys using the regression-based differences-in-differences method. Data analysis was performed from October 2023 to February 2024.ExposureThe South Carolina Choose Well contraceptive access initiative seeks to fill contraceptive access gaps and increase provision of a full range of contraceptive methods through engagement with a wide range of health care organizations across the state.Main Outcomes and MeasuresChanges in contraceptive method use, including long-acting reversible contraception (LARC), intrauterine devices (IUDs), implants, short-acting hormonal injection, and barrier or other methods between the baseline survey (2017-2018) and 3 subsequent surveys (2019-2021).ResultsA total of 1344 female participants (mean [SD] age, 34 [7] years) completed the first survey (667 in Alabama and 677 in South Carolina). Use of LARC significantly increased in South Carolina (119 [17.6%] to 138 [21.1%]) compared with Alabama (120 [18.0%] to 116 [18.1%]; P = .004). Use of IUDs increased in South Carolina (95 [14.0%] to 114 [17.4%]) compared with Alabama (92 [13.8%] to 102 [15.9%]; P = .003). These associations persisted in the adjusted analysis, with a significant increase in the odds of LARC (adjusted odds ratio, 1.24; 95% CI, 1.06-1.44) and IUD (adjusted odds ratio, 1.19; 95% CI, 1.06-1.32) use at follow-up in South Carolina compared with Alabama.Conclusions and RelevanceIn this cohort study of 1344 participants, increases in the use of IUDs in South Carolina were noted after the implementation of the South Carolina Choose Well initiative that were not observed in a peer state with no intervention. Our findings may provide support in favor of statewide contraceptive access initiatives and their role in promoting access to reproductive health services.
Optimal trajectory tracking for uncertain linear discrete‐time systems using time‐varying Q‐learning
Authors: Geiger Maxwell , Narayanan Vignesh , Jagannathan Sarangapani 
Published: April 2024

SummaryThis article introduces a novel optimal trajectory tracking control scheme designed for uncertain linear discrete‐time (DT) systems. In contrast to traditional tracking control methods, our approach removes the requirement for the reference trajectory to align with the generator dynamics of an autonomous dynamical system. Moreover, it does not demand the complete desired trajectory to be known in advance, whether through the generator model or any other means. Instead, our approach can dynamically incorporate segments (finite horizons) of reference trajectories and autonomously learn an optimal control policy to track them in real time. To achieve this, we address the tracking problem by learning a time‐varying ‐function through state feedback. This ‐function is then utilized to calculate the optimal feedback gain and explicitly time‐varying feedforward control input, all without the need for prior knowledge of the system dynamics or having the complete reference trajectory in advance. Additionally, we introduce an adaptive observer to extend the applicability of the tracking control scheme to situations where full state measurements are unavailable. We rigorously establish the closed‐loop stability of our optimal adaptive control approach, both with and without the adaptive observer, employing Lyapunov theory. Moreover, we characterize the optimality of the controller with respect to the finite horizon length of the known components of the desired trajectory. To further enhance the controller's adaptability and effectiveness in multitask environments, we employ the Efficient Lifelong Learning Algorithm, which leverages a shared knowledge base within the recursive least squares algorithm for multitask ‐learning. The efficacy of our approach is substantiated through a comprehensive set of simulation results by using a power system example.
Synergistic Enhancement of Electromagnetic Wave Absorption and Corrosion Resistance Properties of High Entropy Alloy Through Lattice Distortion Engineering
Authors: Qiu Zhengrong , Liu Xiaoyan , Yang Tianyue , Wang Jianbin , Wang Yang , Ma Wenle , Huang Yi 
Published: April 2024

AbstractHigh entropy alloys (HEAs) are promising electromagnetic wave absorption (EMA) materials due to its designable crystal structure, variable electromagnetic properties, and excellent corrosion resistance. However, the impedance mismatch owing to the high electric and dielectric conductivity severely hinders the application of HEAs in the field of EMA. Herein, the lattice distortion of FeCoNiCu HEA is manipulated accurately by doping and annealing strategies to tailor the EMA properties. Significant lattice distortion is observed in the FeCoNiCuC0.37, which leads to a decrease in the electrical conductivity and the creation of abundant dipoles. Owing to the optimal impedance matching and boosted polarization loss, the FeCoNiCuC0.37 delivers a minimal reflection loss of −65.4 dB accompanied by an effective absorption bandwidth (EAB) of 6.81 GHz. After annealing at 200 °C, the EAB of the FeCoNiCuC0.37 is further increased to 7.99 GHz at 1.95 mm, which is better than that of most HEA‐based EMA absorbers reported so far. Moreover, it demonstrates excellent corrosion resistance owing to the more tortuous diffusion path of corrosive medium origin from lattice distortion. Thus, the study provides a new insight into designing high performance HEA‐based EMA materials with superior anti‐corrosion property by lattice distortion engineering.
Spin‐Regulated Fenton‐Like Catalysis for Nonradical Oxidation over Metal Oxide@Carbon Composites
Authors: Li Bofeng , Liu Ya , Hu Kunsheng , Dai Qin , Chen Chunmao , Duan Xiaoguang , Wang Shaobin , Wang Yuxian 
Published: April 2024

AbstractThe spin state of the transition metal species (TMs) has been recognized as a critical descriptor in Fenton‐like catalysis. The raised spin state of dispersed TMs in carbon will enhance the redox processes with adsorbed peroxides and improve the oxidation performance. Nevertheless, establishing the spin‐activity correlations for the encapsulated TM nanoparticles remains challenging because of the difficulties in fine‐tuning the spin state of TM species and the insufficient understanding of orbital hybridization states upon interaction with peroxides. Here, the advantage of the fast‐temperature heating/quenching of microwave thermal shock is taken to engineer the structure and spin state of encapsulated TMs within the N‐doped graphitic carbons. The reduced TMs particle size and enhanced TMs‐carbon coupling increase surface entropy and regulate eg electron filling of the high‐spin TM‐N coordination, endowing electrons with high mobility and facilitating peroxymonosulfate (PMS) adsorption. The strong interactions further uplift the PMS O 2p band position toward the Fermi level and thus elevate the oxidation potential of surface‐activated PMS (PMS*) as the dominant nonradical species for pollutant degradation. The deciphered orbital hybridizations of engineered high‐spin TM and PMS enlighten the smart design of spin‐regulated nanocomposites for advanced water purification.
Transparent Glass Composite Scintillator with High Crystallinity for Efficient Thermal Neutron Detection
Authors: Wang Dazhao , Zhang Shiyu , Chen Jingfei , Tu Degui , Lv Shichao , Wei Zheng , Tang Bin , Sun Zhijia , Qiu Jianrong , Zhou Shifeng 
Published: April 2024

AbstractThe sensitive and rapid detection of thermal neutrons holds significant importance in various fields such as energy utilization, medical treatment, and national defense. However, the available thermal neutron scintillator is difficult to reach this target, mainly limited by the optical and scintillating performance. Herein, the in situ crystallization strategy of glass to construct scintillation glass composites for efficient thermal neutron detection is proposed. The congruent crystallization of the hybridized alkali earth silicate glass system may not only achieve high crystallinity, but also will keep the refractive indexing matching between the precipitated crystal and precursor glass phases. The prepared glass composites feature high luminescence efficiency, optical transmission and excellent neutron response properties. These factors collectively contribute to the robust neutron scintillation performance with a light output of ≈36 000 photons/neutron, which represents the highest value among glass‐based scintillators. Moreover, the composite configuration brings about the additional function of thermal neutron and γ‐ray discrimination. By using this composite scintillator, the neutron detector is constructed and demonstrates its application for detecting thermal neutron and distinguishing it from γ‐ray in an online way. The studies prove that glass composites with high crystallinity are expected to be promising candidates for a new generation of multifunctional neutron detectors.
Intrinsically Stretchable Organic Photodiodes for Faint Near‐Infrared Light Detection and Extendable Cryptographic Imaging
Authors: Qin Mingcong , Bian Yangshuang , Wang Chengyu , Sun Jianzhe , Shi Wenkang , Liu Kai , Zheng Yingqi , Zhang Fan , Liu Guocai , Shao Mingchao , Wen Wei , Zhu Zhiheng , Zhu Mingliang , Zhao Zhiyuan , Wang Hanlin , Liu Yunqi , Yuan Guangcai , Guo Yunlong 
Published: April 2024

AbstractSkin‐like optoelectronic devices have progressed in leaps and bounds, permitting considerable applications such as remote medical diagnosis, optical communication, biometric authentication, and 3D vision imaging. However, achieving extendable imaging in such frontier detectors poses a formidable challenge for stretchable electronic materials and remains largely unexplored. Herein, an ultrasensitive intrinsically stretchable organic photodiode is configured by the spatially modularizable‐assembled elastic photoactive film for faint near‐infrared light detection and extendable imaging. The performance metrics of the stretchable organic photodiodes rival that of commercial photodetectors, including high specific detectivity (D*noise) over 1012 Jones at 850 nm, ultralow noise current of 4.1 × 10−15 A Hz−1/2 and high stretchability up to 100%. Furthermore, it is the first time to simultaneously achieve the extendable near‐infrared cryptographic imaging and stable photoplethysmography signal detection based on stretchable photodiodes. These results signify a significant advancement toward enabling practical scenarios for stretchable organic optoelectronics.