bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maximising CP Violation in naturally aligned Two-Higgs Doublet Models
Authors: Darvishi Neda , Pilaftsis Apostolos , Yu Jiang-Hao 
Published: May 2024

Abstract
The Two-Higgs Doublet Model (2HDM) is a well-motivated theoretical framework that provides additional sources of CP Violation (CPV) beyond the Standard Model (SM). After studying the vacuum topology of a general (convex) 2HDM potential, we unambiguously identify three origins of CPV: (i) Spontaneous CPV (SCPV), where the vacuum manifold has at least two degenerate CPV minima disconnected by domain walls, (ii) Explicit CPV (ECPV) with one single CPV ground state, and (iii) Mixed Spontaneous and Explicit CPV (MCPV), where the theory possesses more than one non-degenerate CPV local minimum. Most importantly, we define a novel complex parameter rCP whose norm and phase control the three different realisations of CPV, at least at the tree level. In all these scenarios, only two CPV phases can be made independent, as any third CPV parameter will always be constrained via the CP-odd tadpole condition. Since ECPV vanishes in 2HDMs where SM Higgs alignment is achieved naturally through accidental continuous symmetries, we analyse the possibility of maximising CPV through soft and explicit breaking of these symmetries. We derive upper limits on key CPV parameters that quantify the degree of SM misalignment from constraints due to the non-observation of an electron Electric Dipole Moment (EDM). Finally, we delineate the CP-violating parameter space of the so-constrained naturally aligned 2HDMs that can further be probed at the CERN Large Hadron Collider (LHC).
Complete UV resonances of the dimension-8 SMEFT operators
Authors: Li Hao-Lin , Ni Yu-Han , Xiao Ming-Lei , Yu Jiang-Hao 
Published: May 2024

Abstract
The effective field theory approach parameterizes the low energy behaviors of all possible ultraviolet (UV) theories in a systematic way. One of the most important tasks is thus to find the connection between the effective operators and their UV origins. The redundancy relations among operators make the connection very subtle, hence we proposed the J-basis prescription to illuminate the correspondence between operators and their UV resonances in the bottom-up way. In this work, we work out the dimension-8 J-basis operators in the standard model effective field theory (SMEFT), and find all the 146 (82) tree-level UV resonances along with their couplings up to mass dimension 5 (4). Furthermore, we point out a few subtleties on operator generation via field redefinition and on the UV Lagrangian for generic spin resonances. We also provide a data base storing our results and a Mathematica notebook for extracting those results for the reader’s conveinence.
Endothelial PDGF-D contributes to neurovascular protection after ischemic stroke by rescuing pericyte functions
Authors: Bernard Maxime , Menet Romain , Lecordier Sarah , ElAli Ayman 
Published: May 2024

AbstractIschemic stroke induces neovascularization of the injured tissue as an attempt to promote structural repair and neurological recovery. Angiogenesis is regulated by pericytes that potently react to ischemic stroke stressors, ranging from death to dysfunction. Platelet-derived growth factor (PDGF) receptor (PDGFR)β controls pericyte survival, migration, and interaction with brain endothelial cells. PDGF-D a specific ligand of PDGFRβ is expressed in the brain, yet its regulation and role in ischemic stroke pathobiology remains unexplored. Using experimental ischemic stroke mouse model, we found that PDGF-D is transiently induced in brain endothelial cells at the injury site in the subacute phase. To investigate the biological significance of PDGF-D post-ischemic stroke regulation, its subacute expression was either downregulated using siRNA or upregulated using an active recombinant form. Attenuation of PDGF-D subacute induction exacerbates neuronal loss, impairs microvascular density, alters vascular permeability, and increases microvascular stalling. Increasing PDGF-D subacute bioavailability rescues neuronal survival and improves neurological recovery. PDGF-D subacute enhanced bioavailability promotes stable neovascularization of the injured tissue and improves brain perfusion. Notably, PDGF-D enhanced bioavailability improves pericyte association with brain endothelial cells. Cell-based assays using human brain pericyte and brain endothelial cells exposed to ischemia-like conditions were applied to investigate the underlying mechanisms. PDGF-D stimulation attenuates pericyte loss and fibrotic transition, while increasing the secretion of pro-angiogenic and vascular protective factors. Moreover, PDGF-D stimulates pericyte migration required for optimal endothelial coverage and promotes angiogenesis. Our study unravels new insights into PDGF-D contribution to neurovascular protection after ischemic stroke by rescuing the functions of pericytes.
On a General Approach to Bessenrodt–Ono Type Inequalities and Log-Concavity Properties
Authors: Gajdzica Krystian , Miska Piotr , Ulas Maciej 
Published: May 2024

AbstractIn recent literature concerning integer partitions one can find many results related to both the Bessenrodt–Ono type inequalities and log-concavity properties. In this note, we offer some general approach to this type of problems. More precisely, we prove that under some mild conditions on an increasing function F of at most exponential growth satisfying the condition $$F(\mathbb {N})\subset \mathbb {R}_{+}$$

F

(
N
)

⊂

R
+

, we have $$F(a)F(b)>F(a+b)$$

F
(
a
)
F
(
b
)
>
F
(
a
+
b
)

for sufficiently large positive integers a, b. Moreover, we show that if the sequence $$(F(n))_{n\ge n_{0}}$$

(
F

(
n
)

)

n
≥

n
0

is log-concave and $$\limsup _{n\rightarrow +\infty }F(n+n_{0})/F(n)<F(n_{0})$$

lim sup

n
→
+
∞

F

(
n
+

n
0

)

/
F

(
n
)

<
F

(

n
0

)

, then F satisfies the Bessenrodt–Ono type inequality.
Hereditäre pulmonal-arterielle Hypertonie
Authors: Eichstaedt Christina A. , Shaukat Memoona , Grünig Ekkehard 
Published: May 2024

ZusammenfassungDie hereditäre pulmonal-arterielle Hypertonie (PAH) kann durch Mutation in mindestens 18 Genen ausgelöst werden. Das am häufigsten veränderte Gen ist das für den „bone morphogenetic protein receptor 2“ (BMPR2). Auch weitere Gene im selben Signalweg sind als PAH-Gene bekannt. Eine positive genetische Testung ist hilfreich, um Differenzialdiagnosen wie eine pulmonale venookklusive Erkrankung zu sichern, und ermöglicht die Testung gesunder Familienangehöriger. Neben dem Patient*innenkollektiv, dem eine genetische Testung besonders dient, geht dieser Beitrag auf die Art der Vererbung der hereditären PAH ein und gibt einen Einblick in erste Therapien, die den BMPR2-Signalweg wieder ins Gleichgewicht bringen.
The association between sexual orientation and psychotic like experiences during adolescence: a prospective cohort study
Authors: Corcoran Emma , Althobaiti Amal , Lewis Glyn , Solmi Francesca , McCloud Tayla , Lewis Gemma 
Published: May 2024

Abstract
Purpose
Psychotic like experiences (PLEs) are relatively common during adolescence and associated with a range of negative outcomes. There is evidence that sexual minorities are at increased risk of mental health problems including depression, anxiety, self-harm and suicidality. However, no study has investigated the association between sexual orientation and psychotic experiences during adolescence. We compared trajectories of PLEs in sexual minority and heterosexual adolescents from 12 to 24 years of age.

Methods
We used data from the Avon Longitudinal Study of Parents and Children (ALSPAC). Participants provided data on sexual orientation at age 16 and PLEs at ages 12, 17 and 24. We used multi-level logistic regression models to test associations between sexual orientation and PLEs, before and after adjusting for covariates. We investigated whether the association differed according to time-point and sex using interaction terms.

Results
We found evidence that the odds of PLEs were 2.35 times (95% Confidence Interval 1.79–3.06, p < 0.0001) higher among sexual minority compared with heterosexual adolescents, across all ages, after adjusting for covariates. There was no evidence that the association between sexual orientation and PLEs differed according to time-point (p = 0.50) or sex (p = 0.29).

Conclusion
We found an increased risk of psychosis in sexual minorities compared with heterosexuals, which was present from around 12 years of age and persisted until age 24. Early interventions to prevent this mental health inequality could include universal interventions to promote inclusivity and acceptance of diverse sexual orientations.
Level of perceived social support, and associated factors, in combat-exposed (ex-)military personnel: a systematic review and meta-analysis
Authors: Grover Laura E. , Williamson Charlotte , Burdett Howard , Palmer Laura , Fear Nicola T. 
Published: May 2024

Abstract
Purpose
Combat deployment increases exposure to potentially traumatic events. Perceived social support (PSS) may promote health and recovery from combat trauma. This systematic review and meta-analysis aimed to synthesize studies investigating the level of PSS and associated factors among (ex-)military personnel who served in the Iraq/Afghanistan conflicts.

Methods
Five electronic databases were searched in August 2023 and searches were restricted to the beginning of the Iraq/Afghanistan conflicts in 2001. The search was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A quality assessment was carried out, and a meta-analysis and narrative synthesis were performed.

Results
In total, 35 papers consisting of 19,073 participants were included. Of these, 31 studies were conducted in the United States (US) and 23 were cross-sectional. The pooled mean PSS score was 54.40 (95% CI: 51.78 to 57.01). Samples with probable post-traumatic stress disorder had a lower mean PSS score (44.40, 95% CI: 39.10 to 49.70). Approximately half of the included studies (n = 19) investigated mental health in relation to PSS, whilst only four explored physical health. The most frequently reported risk factors for low PSS included post-traumatic stress disorder, depression and anxiety, whilst post-traumatic growth and unit support were protective factors.

Conclusion
Higher levels of PSS were generally associated with more positive psychosocial and mental health-related outcomes following deployment. PSS should be targeted in psychosocial interventions and education programmes. Future research should investigate PSS in (ex-)military personnel across other countries and cultures, based on the lack of studies that focused on PSS in countries outside of the US.
Application of cutting fluids in micro-milling — A review
Authors: Kuram Emel , Bagherzadeh Amin , Budak Erhan 
Published: May 2024

AbstractThis article provides an overview of micro-milling operation with a focus on cutting fluids and reviews and discusses dry machining, flood, cryogenic cooling, usage of minimum quantity lubrication (MQL) approach, nanoparticle suspensions, and vegetable oils. In conclusion, the article highlights the future trends and research gaps in field of micro-milling with cutting fluids. Based on works, it can be concluded that researchers explore substitutes for traditional cutting fluids in micro-milling, including vegetable oils, nanofluids, cryogenics, solid lubricants, and de-ionized water. Most cutting fluid studies have focused on micro-milling of aluminum, steel, and titanium, with surface roughness being the most measured output in micro-milling work involving cutting fluids. Overall, the article highlights the need for further research in various aspects of micro-milling operations with cutting fluids, including the development of new cutting strategies, the optimization of cutting fluid delivery methods, and the evaluation of various machinability parameters.
GNSS signal ray-tracing algorithm for the simulation of satellite-to-satellite excess phase in the neutral atmosphere
Authors: Cegla Adam , Rohm Witold , Moeller Gregor , Hordyniec Paweł , Trzcina Estera , Hanna Natalia 
Published: May 2024

AbstractTraditionally, GNSS space-based and ground-based estimates of tropospheric conditions are performed separately. It leads to limitations in the horizontal (e.g., a single space-based radio occultation profile covers a 300 km slice of the troposphere) and vertical resolution (e.g., ground-based estimates of troposphere conditions have spacing equal to stations’ distribution) of the tropospheric products. The first stage to achieve an integrated model is to create an effective 3D ray-tracing algorithm for the satellite-to-satellite (radio occultation) path reconstruction. We verify the consistency of the simulated data with the RO observations from the Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC-1) Data Analysis and Archive Center (CDAAC) in terms of excess phase and bending angle. The results show that our solution provides an effective RO excess phase, with a relative error varying from 35% at the height of 25–30 km (1.0–1.5 m) to 0.5% at heights 5–10 km (0.1–1 m) and 14 to 2% at heights below 5 km (2–14 m). The bending angle retrieval on simulated data attained for high-resolution ray-tracing, bias lower than 2% with respect to the observed bending angle. The optimal solution takes about 1 s for one transmitter–receiver pair with a tangent point below 5 km altitude. The high-resolution processing solution takes 3 times longer.
A role for sirtuin 1 in FGF23 activation following β-glycerophosphate treatment
Authors: Ratsma Danielle M. A. , Muller Max , Koedam Marijke , Zillikens M. Carola , van der Eerden Bram C. J. 
Published: May 2024

AbstractPhosphate homeostasis is vital for many biological processes and disruptions in circulating levels can be detrimental. While the mechanisms behind FGF23 regulation have been regularly studied, the role of extracellular phosphate sensing and its impact on fibroblast growth factor 23 (FGF23) expression remains unclear. This study aimed to investigate the involvement of reactive oxygen species (ROS), silent information regulator 1 (SIRT1), and Hairy and Enhancer of Split-1 (HES1) in regulating FGF23 in FGF23 expressing MC3T3-E1 cells. MC3T3-E1 cells treated with β-glycerophosphate (BGP) resulted in increased Fgf23 expression. Inhibition of ROS formation by inhibition of NADPH oxidase, which is essential for ROS production, did not affect this response to BGP, suggesting ROS is not involved in this process. Moreover, treatment with tert-butyl hydroperoxide (TBHP), a ROS-inducing agent, did not increase Fgf23 expression. This suggests that ROS machinery is not involved in FGF23 stimulation as previously suggested. Nonetheless, inhibition of SIRT1 using Ex527 eliminated the Fgf23 response to BGP, indicating its involvement in FGF23 regulation after BGP treatment. Indeed, activation of SIRT1 using SRT1720 increased Fgf23 expression. Moreover, transcription factor Hes1 was upregulated by BGP treatment, which was diminished when cells were treated with Ex527 implying it is also regulated through SIRT1. These findings suggest the existence of an upstream SIRT1-HES1 axis in the regulation of FGF23 by phosphate, though we were unable to find a role for ROS in this process. Further research should provide insights into phosphate homeostasis and potential therapeutic targets for phosphate-related disorders.
PD-L1 expression, tumor-infiltrating lymphocytes, and mismatch repair proteins status in digestive neuroendocrine neoplasms: exploring their potential role as theragnostic and prognostic biomarkers
Authors: Multone Eléonore , La Rosa Stefano , Sempoux Christine , Uccella Silvia 
Published: May 2024

AbstractTheragnostic biomarkers are still needed to select patients with digestive neuroendocrine neoplasms (NENs) for an optimal management. The PD-1/PD-L1 pathway plays a pivotal role in T cells activation and host immune response to cancer and PD-L1 expression in tumor and/or immune cells is used to identify patients who would benefit of treatment with immune checkpoint inhibitors. However, its role as a biomarker is still unclear in digestive NENs. We investigated PD-L1 expression in 68 well-characterized digestive NENs (32 NETs, 32 NECs and 4 MiNENs) and TPS and CPS scores were calculated. In addition, tumor infiltrating T-lymphocytes and mismatch repair protein expression (MMR) were evaluated. All results were correlated with clinicopathological features. PD-L1 expression was higher in NECs than in NETs: TPS > 1% and/or CPS > 1 were observed in 16% of NETs, 68.8% of NECs and 50% of MiNENs (p: 0.05). The mean TPS score in positive cases was 6.3% in NETs, 16.2% in NECs and 5% in MiNENs. The CPS score was 4.8 in NETs, 8.1 in NECs and 6 in MiNENs. MMR-deficient neoplasms were more frequently observed in NECs than in NETs (p: < 0.05) as well as intra-tumor immune infiltration (p: 0.00001). No correlation between PD-L1 expression and survival or other clinicopathological parameters was observed. Our results suggest that treatment with immune checkpoint inhibitors may have a potential role only in selected cases, mainly in NECs and MiNENs.
Breastfeeding and risk of food allergy and allergic rhinitis in offspring: a systematic review and meta-analysis of cohort studies
Authors: Ding Yali , Zhu Chengbi , Li Shuo , Liu Naixu , Liu Qian , Li Weifeng , Zhao Changjiang , Yuan Bin 
Published: May 2024

AbstractThe association between breastfeeding and the occurrence of allergic rhinitis (AR) and food allergy (FA) in offspring remains inconclusive. This review aims to comprehensively explore the potential relationships between various patterns and durations of breastfeeding and allergic diseases in offspring. We systematically searched PubMed, EMBASE, Cochrane, WOS databases, and Google Scholar for observational studies published up to March 30, 2023, that investigated the link between breastfeeding and allergies in offspring. The quality of the studies was assessed using the Newcastle-Ottawa Scale (NOS) and Joanna Briggs Institute (JBI). Pooled odds ratios (OR) and 95% confidence intervals (95% CI) were calculated employing an appropriate model based on the degree of heterogeneity. A total of 68 studies, encompassing 772,142 children, were ultimately included. The findings indicated that breastfeeding for more than 6 months was associated with a reduced risk of AR (OR = 0.88, 95% CI: 0.79 to 0.98) but posed a risk for FA (OR = 1.69, 95% CI: 1.27 to 2.25). Exclusive breastfeeding exhibited a protective effect against AR (OR = 0.94, 95% CI: 0.90 to 0.97), whereas non-breastfeeding was identified as a risk factor for AR (OR = 1.48; 95% CI: 1.03 to 2.12). No significant association was observed between breastfeeding patterns and FA. Conclusion: Breastfeeding for more than 6 months proves to be an effective preventive measure against AR. However, large prospective high-quality studies are needed to investigate the potential risk of FA in children with prolonged breastfeeding.

What is Known:• The impact of breastfeeding on allergic rhinitis and food allergy in offspring is controversial.• Previous meta-analyses fail to prove the effect of breastfeeding on food allergy in offspring of all ages.

What is New:• Breastfeeding for more than 6 months proves to be an effective preventive measure against AR. However, it potentially elevates the risk of FA in children. Non-breastfeeding is linked to an increased risk of AR in children, but there is no evidence of an association between breastfeeding patterns and FA in children.• The impact of breastfeeding on allergic rhinitis and food allergy in offspring may vary with the time and pattern of breastfeeding.
Use superb microvascular imaging to diagnose and predict metastatic cervical lymph nodes in patients with papillary thyroid carcinoma
Authors: Huang Ting , Huang Pin-Tong , Luo Zhi-Yan , Lv Ji-Fang , Jin Pei-Le , Zhang Tao , Zhao Yu-Lan , Wang Yong , Hong Yu-Rong 
Published: May 2024

Abstract
Purpose
Papillary thyroid carcinoma (PTC) with metastatic lymph nodes (LNs) is closely associated with disease recurrence. This study accessed the value of superb microvascular imaging (SMI) in the diagnosis and prediction of metastatic cervical LNs in patients with PTC.

Methods
A total of 183 cervical LNs (103 metastatic and 80 reactive) from 116 patients with PTC were analysed. Metastatic cervical LNs were confirmed by pathology or/and cytology; reactive cervical LNs were confirmed by pathology or clinical features. The characteristic of conventional ultrasound (US) was extracted using univariate and multivariate analyses. The diagnostic performance of US and SMI were compared using the area under the receiver operating curve (AUC) with corresponding sensitivity and specificity. A nomogram was developed to predict metastatic LNs in patients with PTC, based on multivariate analyses.

Results
L/S < 2, ill-defined border, absence of hilum, isoechoic or hyperechoic, heterogeneous internal echo, peripheral or mixed vascular pattern on color Doppler flow imaging (CDFI) and SMI, and a larger SMI vascular index appeared more frequently in metastatic LNs in the training datasets than in reactive LNs (P < 0.05). The diagnostic sensitivity, specificity and accuracy of SMI vs US are 94.4% and 87.3%, 79.3% and 69.3%, and 87.6% and 79.1%, respectively; SMI combined with US exhibited a higher AUC [0.926 (0.877–0.975)] than US only [0.829 (0.759–0.900)]. L/S < 2, peripheral or mixed vascular type on CDFI, and peripheral or mixed vascular types on SMI were independent predictors of metastatic LNs with PTC. The nomogram based on these three parameters exhibited excellent discrimination, with an AUC of 0.926.

Conclusion
SMI was superior to US in diagnosing metastatic LNs in PTC. US combined with SMI significantly improved the diagnostic accuracy of metastatic cervical LNs with PTC. SMI is efficacious for differentiating and predicting metastatic cervical LNs.
Robotic technology in surgery; a classification system of soft tissue surgical robotic devices
Authors: Cowan Brandon , Gomes Camilla , Morris Paul , Fryrear Raymond , Petraiuolo William , Walton Matt , Alseidi Adnan , Horgan Santiago , Hagen Monika 
Published: May 2024

Abstract
Background
The field of robotic-assisted surgery is rapidly growing as many robotic surgical devices are in development and about to enter the market. Currently, there is no universally accepted language for labeling the different robotic systems. To facilitate this communication, we created what is, to our knowledge, the first classification of surgical robotic technologies that organizes and classifies surgical robots used for endoscopy, laparoscopy and thoracoscopy.

Methods
We compiled a list of surgical robots intended to be used for endoscopy, laparoscopy, and/or thoracoscopy by searching United States, European, Hong Kong, Japan, and Korean databases for approved devices. Devices showcased at the 2023 Annual Meeting for the Society of Robotic Surgery were added. We also systematically reviewed the literature for any existing surgical robotic classifications or categorizations. We then created a multidisciplinary committee of 8 surgeons and 2 engineers to construct a proposed classification of the devices included in our search.

Results
We identified 40 robotic surgery systems intended to be used for endoscopy, laparoscopy and/or thoracoscopy. The proposed classification organizes robotic devices with regard to architecture, port design, and configuration (modular carts, multi-arm integrated cart, table-attachable or arm-table integration).

Conclusion
This 3-level classification of robotic surgical devices used for endoscopy, laparoscopy and/or thoracoscopy describes important characteristics of robotic devices systematically.