bluuebunny/crossref_metadata_2025_split huggingface dataset:
Climate change impact on barrier island freshwater lenses and their transition zones: a multi-parameter study
Authors: Thissen Lena , Greskowiak Janek , Gaslikova Lidia , Massmann Gudrun 
Published: June 2024

AbstractFreshwater lenses and their freshwater–saltwater transition zones are affected by climate change. Both sea-level rise and groundwater recharge influence freshwater volume and transition zone thickness. This study used a semi-generic approach to investigate climate change effects on freshwater lenses: a hypothetical island cross-section was combined with real-world boundary conditions. Sea-level projections including tides and storm surges, annual mean sea-level rise data, and monthly recharge projections of several climate models of the German barrier island Norderney in the North Sea were used to evaluate changes in freshwater lens and transition zone size between 1971–2000 and 2071–2100. Firstly, impacts of sea-level and recharge boundary conditions were investigated on islands of different widths. Secondly, a multi-parameter study was conducted focussing on variations of several relevant hydrogeological parameters. Results showed that it is very likely but not certain that freshwater lens volume and depth will decrease and transition zone thickness increase as a consequence of climate change. Model predictions revealed a strong dependency on the employed climate models and to a lesser extent on the hydrogeological parameters, at least for the parameter ranges used in this study. Of all hydrogeological parameters tested, the largest effects were caused by the hydraulic conductivity and its anisotropy. Furthermore, the study showed that boundary conditions have larger impacts on smaller islands. These results illustrate the importance of using projections from climate models in a sufficiently high resolution. Furthermore, their uncertainties and changes in variability of boundary conditions should be considered in studies about climate change impacts on freshwater lenses.
Self-swabbing versus assisted swabbing for viral detection by qRT-PCR: the experience from SARS-CoV-2 based on a meta-analysis of six prospectively designed evaluations conducted in a UK setting
Authors: Fowler Tom , Chapman David , Futschik Matthias E. , Tunkel Sarah A. , Blandford Edward , Turek Elena , Kolade Olumide , da Cunha Sergio Souza , Dodgson Andrew , Klapper Paul , Sudhanva Malur , Davies Lindsey , Hill Sue , Hopkins Susan , Peto Tim 
Published: June 2024

Abstract
Purpose
In April 2020, the UK Government implemented NHS Test and Trace to provide SARS-CoV-2 quantitative reverse transcription polymerase chain reaction (qRT-PCR) testing for the public, with nose-and-throat swabbing for samples performed by trained staff. Self-swabbing (SS) would allow rapid scale-up of testing capacity and access. Six studies were undertaken to determine whether SS was as effective for detecting SARS-CoV-2 as swabbing performed by trained staff.

Methods
Six prospective studies were conducted between April–October 2020, using six swab/media combinations. Differences between assisted swabbing (AS) and SS were evaluated for concordance, positivity, sensitivity, cycle threshold (Ct) values and void rates. Statistical analysis was performed using 95% confidence intervals (CIs), paired t-tests and model-based methods.

Results
Overall, 3,253 individuals were recruited (median age 37 years, 49% female), with 2,933 having valid paired qRT-PCR results. Pooled concordance rate was 98% (95% CI: 96%, 99%). Positivity rate differences for SS (8.1%) and AS (8.4%) and differences in pooled sensitivities between SS (86%; 95% CI: 78%, 92%) and AS (91%; 95% CI: 78%, 96%) were nonsignificant. Both types of swabbing led to pooled void rates below 2% and strongly correlated Ct values. Age, sex and previous swabbing experience did not have a significant impact on concordance or sensitivity.

Conclusion
The UK adopted a policy to promote self-testing for SARS-CoV-2 based on data demonstrating equivalence of SS versus AS. Positive outcomes with SS are likely generalisable to testing for other respiratory pathogens, and we consider self-sampling and self-testing essential for future pandemic preparedness.
Comparative effectiveness of sodium-glucose cotransporter-2 inhibitors for new-onset gastric cancer and gastric diseases in patients with type 2 diabetes mellitus: a population-based cohort study
Authors: Chou Oscar Hou In , Chauhan Vinod Kumar , Chung Cheuk To Skylar , Lu Lei , Lee Teddy Tai Loy , Ng Zita Man Wai , Wang Karin Kai Wing , Lee Sharen , Liu Haipeng , Pang Ronald Ting Kai , Kaewdech Apichat , Cheung Bernard Man Yung , Tse Gary , Zhou Jiandong 
Published: June 2024

Abstract
Objective
To compare the risks of gastric cancer and other gastric diseases in patients with type-2 diabetes mellitus (T2DM) exposed to sodium-glucose cotransporter 2 inhibitors (SGLT2I), dipeptidyl peptidase-4 inhibitors (DPP4I) or glucagon-like peptide-1 receptor agonists (GLP1a).

Design
This was a population-based cohort study of prospectively collected data on patients with T2DM prescribed SGLT2I, DPP4I or GLP1a between January 1st 2015 and December 31st 2020 from Hong Kong. The outcomes were new-onset gastric cancer, peptic ulcer (PU), acute gastritis, non-acute gastritis, and gastroesophageal reflux disease (GERD). Propensity score matching (1:1) using the nearest neighbour search was performed, and multivariable Cox regression was applied. A three-arm comparison between SGLT2I, DPP4I and GLP1a was conducted using propensity scores with inverse probability of treatment weighting.

Results
A total of 62,858 patients (median age: 62.2 years old [SD: 12.8]; 55.93% males; SGLT2I: n = 23,442; DPP4I: n = 39,416) were included. In the matched cohort, the incidence of gastric cancer was lower in SGLT2I (Incidence rate per 1000 person-year, IR: 0.32; 95% confidence interval, CI 0.23–0.43) than in DPP4I (IR per 1000 person-year: 1.22; CI 1.03–1.42) users. Multivariable Cox regression found that SGLT2I use was associated with lower risks of gastric cancer (HR 0.30; 95% CI 0.19–0.48), PU, acute gastritis, non-acute gastritis, and GERD (p < 0.05) compared to DPP4I use. In the three-arm analysis, GLP1a use was associated with higher risks of gastric cancer and GERD compared to SGLT2I use.

Conclusions
The use of SGLT2I was associated with lower risks of new-onset gastric cancer, PU, acute gastritis, non-acute gastritis, and GERD after matching and adjustments compared to DPP4I use. SGLT2I use was associated with lower risks of GERD and gastric cancer compared to GLP1a use.

Graphical abstract
Appropriate definition of non-metastatic castration-resistant prostate cancer (nmCRPC) and optimal timing of androgen receptor signaling inhibitor (ARSI)
Authors: Matsumoto Kazuhiro , Kosaka Takeo , Takeda Toshikazu , Fukumoto Keishiro , Yasumizu Yota , Tanaka Nobuyuki , Morita Shinya , Mizuno Ryuichi , Asanuma Hiroshi , Oya Mototsugu 
Published: June 2024

Abstract
Background
Defined by rising PSA levels under androgen deprivation therapy (ADT) despite no visible metastases on conventional imaging, non-metastatic castration-resistant prostate cancer (nmCRPC) represents a complex clinical challenge. A significant subset of these patients rapidly develops metastatic disease, negatively impacting survival. We examined the difference in prognosis of nmCRPC patients according to the timing of therapeutic interventions with androgen receptor signaling inhibitor (ARSI).

Methods
We examined 102 nmCRPC patients treated with ARSI. We divided patients according to their PSA levels when ARSI was administered: Cohort A (PSA 0.5–2.0 ng/mL), Cohort B (PSA 2.0–4.0 ng/mL), and Cohort C (PSA > 4.0 ng/mL). Utilizing the Kaplan–Meier method for survival analysis, our analytical starting point was the moment when PSA levels exceeded 0.5 ng/mL post-ADT nadir, ensuring a fair comparison and minimizing lead-time bias.

Results
After excluding 5 patients whose PSA nadir after ADT > 0.5 ng/mL, patient distribution across Cohort A, Cohort B, and Cohort C was 32, 24, and 41 patients, respectively. Kaplan–Meier survival analysis highlighted a 2-year metastasis-free survival rate of 97% for Cohort A, 87% for Cohort B, and 73% for Cohort C. A marked statistical difference emerged when comparing Cohort A with Cohorts B and C, with a p-value of 0.043.

Conclusion
The timely initiation of ARSI is paramount in nmCRPC management. Our findings strongly advocate for consideration of ARSI administration in nmCRPC patients before their PSA levels exceed 2.0 ng/mL. Our results indicated a PSA threshold of 1.0 ng/mL for nmCRPC definition which is more reasonable to administer ARSI without delay.
MBFair: a model-based verification methodology for detecting violations of individual fairness
Authors: Ramadan Qusai , Konersmann Marco , Ahmadian Amir Shayan , Jürjens Jan , Staab Steffen 
Published: June 2024

Abstract
Decision-making systems are prone to discrimination against individuals with regard to protected characteristics such as gender and ethnicity. Detecting and explaining the discriminatory behavior of implemented software is difficult. To avoid the possibility of discrimination from the onset of software development, we propose a model-based methodology called MBFair that allows for verifying UML-based software designs with regard to individual fairness. The verification in MBFair is performed by generating temporal logic clauses, whose verification results enable reporting on the individual fairness of the targeted software. We study the applicability of MBFair using three case studies in real-world settings including a bank services system, a delivery system, and a loan system. We empirically evaluate the necessity of MBFair in a user study and compare it against a baseline scenario in which no modeling and tool support is offered. Our empirical evaluation indicates that analyzing the UML models manually produces unreliable results with a high chance of 46% that analysts overlook true-positive discrimination. We conclude that analysts require support for fairness-related analysis, such as our MBFair methodology.
Celebrating 10 Years of the HIMSS-SIIM Enterprise Imaging Community and Enterprise Imaging Informatics
Authors: Roth Christopher J. , Petersilge Cheryl A. , Cram Dawn , Garriott Kim , Lannum Lou , Carey Cheryl K. , Medina Nikki , Kwiatkoski Tammy , Whitfill James T. , Towbin Alexander J. 
Published: June 2024

AbstractIn response to the growing recognition of enterprise imaging as a critical component of healthcare’s digital transformation, in 2014, the Healthcare Information and Management Systems Society (HIMSS) and the Society for Imaging Informatics in Medicine (SIIM) signed a Memorandum of Understanding to form the HIMSS-SIIM Enterprise Imaging Community (HSEIC). At the time of the agreement, the two organizations decided to collaborate to lead enterprise imaging development, advancement, and adoption. This paper celebrates the past 10 years of the HSEIC’s thought leadership, industry partnerships, and impact while also looking ahead to identify enterprise imaging challenges to solve in the next decade.
Tight contact structures on some families of small Seifert fiber spaces
Authors: Wan S. 
Published: June 2024

AbstractSuppose K is a knot in a 3-manifold Y, and that Y admits a pair of distinct contact structures. Assume that K has Legendrian representatives in each of these contact structures, such that the corresponding Thurston-Bennequin framings are equivalent. This paper provides a method to prove that the contact structures resulting from Legendrian surgery along these two representatives remain distinct. Applying this method to the situation where the starting manifold is $$-\Sigma(2,3,6m+1)$$

-
Σ
(
2
,
3
,
6
m
+
1
)

and the knot is a singular fiber, together with convex surface theory we can classify the tight contact structures on certain families of Seifert fiber spaces.
The climate niche of Homo Sapiens
Authors: Tol Richard S. J. 
Published: June 2024

AbstractThe increasing atmospheric concentrations of greenhouse gases will place humans in climates that are unprecedented in the evolution of the species. I use the ecological definition of the human niche in climate space, and combine this with a new constellation of methods from extreme value statistics to study human occupation near the boundaries of that niche. I find that the temperature distribution has a thin tail whereas the tail of precipitation is thick. This thick tail reflects that humans are used to a wide range of rainfall regimes, so future precipitation changes, although leading to unprecedented rainfall, are less likely to pose a major challenge. An increase in temperature, on the other hand, will put hundreds of millions of people in heat that is not just unprecedented and but also hard to imagine from extrapolating current temperatures. These findings are qualitatively similar but an order of magnitude smaller than previous studies.
Risk-Aware Framework Development for Disruption Prediction: Alcator C-Mod and DIII-D Survival Analysis
Authors: Keith Zander , Nagpal Chirag , Rea Cristina , Tinguely R. Alex 
Published: June 2024

AbstractSurvival regression models can achieve longer warning times at similar receiver operating characteristic performance than previously investigated models. Survival regression models are also shown to predict the time until a disruption will occur with lower error than other predictors. Time-to-event predictions from time-series data can be obtained with a survival analysis statistical framework, and there have been many tools developed for this task which we aim to apply to disruption prediction. Using the open-source Auton-Survival package we have implemented disruption predictors with the survival regression models Cox Proportional Hazards, Deep Cox Proportional Hazards, and Deep Survival Machines. To compare with previous work, we also include predictors using a Random Forest binary classifier, and a conditional Kaplan-Meier formalism. We benchmarked the performance of these five predictors using experimental data from the Alcator C-Mod and DIII-D tokamaks by simulating alarms on each individual shot. We find that developing machine-relevant metrics to evaluate models is an important area for future work. While this study finds cases where disruptive conditions are not predicted, there are instances where the desired outcome is produced. Giving the plasma control system the expected time-to-disruption will allow it to determine the optimal actuator response in real time to minimize risk of damage to the device.
The IFMIF-DONES Diagnostics and Control Systems: Current Design Status, Integration Issues and Future Perspectives Embedding Artificial Intelligence Tools
Authors: Cappelli M. , Torregrosa-Martin C. , Diaz J. , Ibarra A. 
Published: June 2024

AbstractAs an integral part of the European strategy for advancing fusion-generated electricity, IFMIF-DONES represents a high-intensity neutron irradiation plant with the main purpose of assessing the suitability of materials for fusion reactor applications. Its primary mission is to examine how materials respond to irradiation within a neutron flux that mimics the conditions expected in the first wall of the proposed DEMO reactor, which is intended to succeed ITER. Consequently, IFMIF-DONES, whose construction is slated to commence shortly, plays a pivotal role in aiding the development, approval, and safe operation of DEMO, as well as future fusion power plants. This paper provides a quick overview of the current development of the IFMIF-DONES neutron source with a particular snapshot of the present engineering design status for what concerns the instrumentation and control systems together with its complex diagnostics, that guarantees the safe monitoring, supervision and regulation of all operations. The current status of design, after the completion of the preliminary design phase is presented, as well as the existing and future plans for their integration also using some of the new capabilities offered by Artificial Intelligence tools.
Reflexives and politeness: possessive pronouns in Russian imperative sentences
Authors: Perevozchikova Tatiana 
Published: June 2024

AbstractIn Russian, a specialized reflexive possessive pronoun must be used to indicate coreference between the possessor and the subject. However, it has been observed that in the first and second person plural, the reflexivization rule is often violated, and a non-reflexive possessive is used for subject coreference. Existing studies do not distinguish between singular formal and plural informal readings in the second person, assuming no difference between the two contexts. Furthermore, there is limited knowledge regarding the use of possessives in imperative contexts, as previous research has primarily focused on indicatives.This article aims to investigate the use of possessive pronouns in both formal and informal imperative contexts by addressing two questions. First, how often is a non-reflexive possessive used to indicate coreference with the subject in Russian imperative sentences? Second, what combination of semantic and pragmatic factors allows its use? Apart from the semantic factors that are well documented in the existing literature (referentiality, animacy and alienability of the possessum), we will consider three pragmatic dimensions of politeness that have not been considered so far: form or address (informal $ty$
t
y
/ formal $Vy$
V
y
), type of imperative (speaker- / hearer-oriented) and verbal aspect (perfective / imperfective).The study analyzed the use of possessive pronouns in imperatives in the spoken subcorpus of the Russian National Corpus using generalized linear mixed models and random forests. The findings suggest that the choice of possessive is strongly influenced by the form of address ($ty$
t
y
/ $Vy$
V
y
). When addressing the listener with the informal $ty$
t
y
, a reflexive possessive is almost exclusively used. When addressing the listener with the formal $Vy$
V
y
, both possessives are used equally often. The choice between them depends on several factors, including the referentiality and alienability of the possessum, the type of imperative, and the verbal aspect. The non-reflexive form is preferred when the possessum is referential, the imperative is speaker-oriented, and, to a lesser extent, when the possessum is alienable and the verb is in the perfective aspect. Additionally, some verbs such as ‘give’ and ‘show’ strongly prefer a non-reflexive possessive.The results suggest that a reflexive possessive has become the default for subject coreference in Russian second person singular informal contexts. In formal contexts, however, the change is still ongoing, and a non-reflexive possessive is used to express the referential uniqueness of the possessum and to convey negative politeness towards the addressee.
Association between triglyceride-glucose index and chronic kidney disease: results from NHANES 1999–2020
Authors: Li Xiaowan , Wang Lanyu , Zhou Hongyi , Xu Hongyang 
Published: June 2024

Abstract
Aims
Examining the connection between the triglyceride-glucose (TyG) index and chronic kidney disease (CKD) was the aim of this investigation.

Methods
Data from the National Health and Nutrition Examination Survey (NHANES) covering the years 1999–2020 were analyzed in this study. The TyG index was calculated as Ln (triglycerides (mg/dl) * fasting glucose (mg/dl)/2). The two criteria used to diagnose CKD were low estimated glomerular filtration rate (eGFR) (eGFR < 60 mL/min/1.73m2) or albuminuria (urine albumin-to-creatinine ratio (ACR) ≥ 30 mg/g). To look into the independent associations between TyG index levels with CKD, albuminuria, and low-eGFR, weighted multivariable logistic regression and generalized additive models were employed. To assess and contrast the diagnostic ability, receiver operating characteristic (ROC) curves were employed.

Results
Out of 18,078 total participants recruited, 48.54% were male. 8.48 + 0.68 was the mean value of the TyG index. CKD, albuminuria, and low-eGFR were common, with respective prevalences of 17.06%, 11.26%, and 8.03%, respectively. The TyG index and CKD were observed to positively correlate (OR = 4.03; 95% CI 1.81, 8.96). In US adults between the ages of 41 and 60, a J-shaped connection was found between the two. Furthermore, a higher TyG index is associated with a higher prevalence of albuminuria (OR = 6.11; 95% CI 2.64, 14.14). Subgroup analyses and interaction tests revealed that different stratifications did not significantly affect the relationship between TyG index and CKD, albuminuria, and low-eGFR. Comparing the TyG index to other indicators [lipid accumulation product (LAP), Visceral adiposity index (VAI), and the triglyceride glucose–body mass index (TyG-BMI)], it may be more accurate and discriminative in predicting CKD and albuminuria.

Conclusion
When predicting CKD and albuminuria, the TyG index may be a more useful marker when compared to other markers (LAP, VAI, and TyG-BMI index). In addition, in American adults aged 41–60, the TyG index shows a J-shaped relationship with CKD. As a result, when assessing the kidney health of US adults, we must pay close attention to the significance of the TyG index.
How Important is European Integration for Pro-European Voters in Times of Politicization?
Authors: Rapp Milena 
Published: June 2024

AbstractThe increasing success of Eurosceptic parties and multiple European crises have fostered the politicization of European integration. However, we know little about how pro-European voters behave in this politicized environment. How important is European integration for pro-European voters? Do they care more about European integration when their vision of Europe is increasingly contested? The past 15 years have been characterized by persistent politicization of Eurosceptic parties and an increasing willingness of Europhile parties to engage with European topics. Moreover, European crises illustrated potential consequences of political disintegration. I expect these developments to be reflected in an increasing salience of European integration among pro-European voters. I derive salience estimates from spatial vote models encompassing four issue dimensions to track the development of salience. I use data from the European Social Survey, the European Election Studies, and the Chapel Hill Expert Survey, which cover many EU member states between 2008 and 2019. The results show that the salience of the European integration issue is most pronounced among Eurosceptic voters, while it is less pronounced among pro-European voters. However, in countries with a successful Eurosceptic party, it is more likely that the European integration issue also matters to pro-European voters. Moreover, there has been an increasing trend over time that European integration is not only important for anti- but also for pro-European voters across Europe.