bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Synthesis of 1,3‐Benzothiazol‐2(3H)‐one and Some Its Derivatives.
Authors: Velikorodov A. V. , Kuanchalieva A. K. , Melent'eva E. A. , Titova O. L. 
Published: April 2012

AbstractAcylation of 2‐mercapto‐aniline (I) with chloroformate (II) affords unexpectedly disulfide (III).
ChemInform Abstract: Covalently Immobilized Tris(triazolyl)methanol—Cu(I) Complexes: Highly Active and Recyclable Catalysts for CuAAC Reactions.
Authors: Ozkal Erhan , Oezcubukcu Salih , Jimeno Ciril , Pericas Miquel A. 
Published: April 2012

AbstractA new copper catalyst immobilized onto Merrifield resin is used to promote cycloaddition reactions of alkynes to several azides.
ChemInform Abstract: Fluorine‐Containing Quinoline and Quinoxaline Styryl Derivatives: Synthesis and Photophysical Properties.
Authors: Nosova E. V. , Trashakhova T. V. , Ustyugov V. S. , Mochul'skaya N. N. , Valova M. S. , Lipunova G. N. , Charushin V. N. 
Published: April 2012

AbstractThe condensation of 2‐methylbenzazines with aromatic aldehydes affords the corresponding (E)‐2‐styryl‐substituted 6,7‐difluoroquinolines and ‐quinoxalines, which exhibit photoluminescence in MeCN solution.
ChemInform Abstract: Synthesis of 12‐Oxobenzo[c]phenanthridinones and 4‐Substituted 3‐Arylisoquinolones via Vilsmeier—Haack Reaction.
Authors: Khadka Daulat Bikram , Yang Su Hui , Cho Suk Hee , Zhao Chao , Cho Won‐Jea 
Published: April 2012

AbstractThe synthesis of a large array of substituted isoquinolones using the Vilsmeier—Haack formylation as key reaction is reported.
ChemInform Abstract: σH‐Adducts of 1‐Alkyl‐1,4‐diazinium Salts as the Sources of Biradicals in the Synthesis of Tetraazaphenanthrenes.
Authors: Verbitskiy E. V. , Slepukhin P. A. , Ezhikova M. A. , Kodess M. I. , Shvachko Yu. N. , Starichenko D. V. , Rusinov G. L. , Charushin V. N. 
Published: April 2012

AbstractThe dimerization of 1,4‐diazines (I) affords mixtures of two diastereomers.
ChemInform Abstract: Enantioselective Total Synthesis of (—)‐Neovibsanin G and (—)‐14‐epi‐Neovibsanin G.
Authors: Mak Jeffrey Y. W. , Williams Craig M. 
Published: April 2012

AbstractKey step is an EtAlCl2‐mediated cascade leading to the bicyclo[3.3.]nonane core in one step.
Synthesis of Gd and 68Ga Complexes in Conjugation with a Conformationally Optimized RGD Sequence as Potential MRI and PET Tumor‐Imaging Probes
Authors: Manzoni Leonardo , Belvisi Laura , Arosio Daniela , Bartolomeo Maria Paola , Bianchi Aldo , Brioschi Chiara , Buonsanti Federica , Cabella Claudia , Casagrande Cesare , Civera Monica , De Matteo Marilenia , Fugazza Lorenza , Lattuada Luciano , Maisano Federico , Miragoli Luigi , Neira Cristina , Pilkington‐Miksa Michael , Scolastico Carlo 
Published: April 2012

AbstractWe report the synthesis of novel chelates of Gd and 68Ga with DPTA, DOTA, HP‐DOA3, as well as with AAZTA, a novel chelating agent developed by our research group. These chelating agents were appropriately conjugated, prior to metal complexation, with DB58, an RGD peptidomimetic, conformationally constrained on an azabicycloalkane scaffold and endowed with high affinity for integrin ανβ3. Because ανβ3 is involved in neo‐angiogenesis in solid tumors and is also directly expressed in cancer cells (e.g. glioblastomas, melanomas) and ovarian, breast, and prostate cancers, these constructs could prove useful as molecular imaging probes in cancer diagnosis by MRI or PET techniques. Molecular modeling, integrin binding assays, and relaxivity assessments allowed the selection of compounds suitable for multiple expression on dendrimeric or nanoparticulate structures. These results also led us to an exploratory investigation of 68Ga complexation for the promising 68Ga‐PET technique; the AAZTA complex 15(68Ga) exhibited uptake in a xenograft model of glioblastoma, suggesting potentially useful developments with new probes with improved affinity.
Structural Studies on Ionic Liquid/Water/Peptide Systems by HR‐MAS NMR Spectroscopy
Authors: Mrestani‐Klaus Carmen , Richardt Annekathrin , Wespe Christian , Stark Annegret , Humpfer Eberhard , Bordusa Frank 
Published: April 2012

AbstractThe present work reports on an assessment of high‐resolution magic angle spinning (HR‐MAS) NMR spectroscopy for structural investigations of peptides dissolved in aqueous ionic liquids. Highly resolved one‐ and two‐dimensional NMR spectra are obtained that allow for complete proton resonance assignments of both the peptides as solutes and the ionic liquids as solvents. Successful application of the HR‐MAS method facilitates for the first time high‐resolution NMR analysis of complex ionic liquid/peptide systems at the molecular level, mainly on the basis of chemical‐shift changes.
Microwave‐Assisted Synthesis of Fluorescent Ag Nanoclusters in Aqueous Solution
Authors: Li Rongqing , Wang Chunlei , Bo Fan , Wang Zhuyuan , Shao Haibao , Xu Shuhong , Cui Yiping 
Published: April 2012

AbstractFluorescent Ag nanoclusters are of significant interest because they provide the bridge between atomic and nanoparticle behavior in noble metals. Herein, microwave irradiation was originally used for the synthesis of water‐soluble fluorescent Ag nanoclusters. As‐prepared Ag nanoclusters present red fluorescence emission around 608 nm and a characteristic absorption peak at about 508 nm. Transmission electron microscopy (TEM) shows an average size of 1.6 nm for Ag nanoclusters. The effect of solution pH on the synthesis process and optical properties of Ag nanoclusters was investigated. The pH‐dependent present form and adsorption capacity of poly(methacrylic acid, sodium salt) (PMAA) ligands are believed to be the reason for the pH effect.
Study of normal and pathological blood vessel morphogenesis in Flt1‐tdsRed BAC Tg mice
Authors: Matsumoto Ken , Azami Takuya , Otsu Ayaka , Takase Haruka , Ishitobi Hiroyuki , Tanaka Junko , Miwa Yoshihiro , Takahashi Satoru , Ema Masatsugu 
Published: April 2012

AbstractBlood vessel development and network patterning are controlled by several signaling molecules, including VEGF, FGF, TGF‐ß, and Ang‐1,2. Among these, the role of VEGF‐A signaling in vessel morphogenesis is best understood. The biological activity of VEGF‐A depends on its reaction with specific receptors Flt1 and Flk1. Roles of VEGF‐A signaling in endothelial cell proliferation, migration, survival, vascular permeability, and induction of tip cell filopodia have been reported. In this study, we have generated Flt1‐tdsRed BAC transgenic (Tg) mice to monitor Flt1 gene expression during vascular development. We show that tdsRed fluorescence is observed within blood vessels of adult mice and embryos, indicative of retinal angiogenesis and tumor angiogenesis. Flt1 expression recapitulated by Flt1‐tdsRed BAC Tg mice overlapped well with Flk1, while Flt1 was expressed more abundantly in endothelial cells of large blood vessels such as dorsal aorta and presumptive stalk cells in retina, providing a unique model to study blood vessel development. genesis 50:561–571, 2012. © 2012 Wiley Periodicals, Inc.
An examination of early childhood perfectionism across anorexia nervosa subtypes
Authors: Halmi Katherine A. , Bellace Dara , Berthod Samantha , Ghosh Samiran , Berrettini Wade , Brandt Harry A. , Bulik Cynthia M. , Crawford Steve , Fichter Manfred M. , Johnson Craig L. , Kaplan Allan , Kaye Walter H. , Thornton Laura , Treasure Janet , Blake Woodside D. , Strober Michael 
Published: April 2012

AbstractObjective:To examine childhood perfectionism in anorexia nervosa (AN) restricting (RAN), purging (PAN), and binge eating with or without purging (BAN) subtypes.Method:The EATATE, a retrospective assessment of childhood perfectionism, and the eating disorder inventory (EDI‐2) were administered to 728 AN participants.Results:EATATE responses revealed general childhood perfectionism, 22.3% of 333 with RAN, 29.2% of 220 with PAN, and 24.8% of 116 with BAN; school work perfectionism, 31.2% with RAN, 30.4% with PAN, and 24.8% with BAN; childhood order and symmetry, 18.7% with RAN, 21.7% with PAN, and 17.8% with BAN; and global childhood rigidity, 42.6% with RAN, 48.3% with PAN and 48.1% with BAN. Perfectionism preceded the onset of AN in all subtypes. Significant associations between EDI‐2 drive for thinness and body dissatisfaction were present with four EATATE subscales.Discussion:Global childhood rigidity was the predominate feature that preceded all AN subtypes. This may be a risk factor for AN. © 2012 by Wiley Periodicals, Inc. (Int J Eat Disord 2012; 45:800–807)
Facile Microwave Synthesis of 3D Flowerlike BiOBr Nanostructures and Their Excellent CrVI Removal Capacity
Authors: Li Guangfang , Qin Fan , Yang Hao , Lu Zhong , Sun Hongzhe , Chen Rong 
Published: April 2012

AbstractA facile and fast microwave irradiation method has been developed to synthesize uniform well‐defined 3D flowerlike BiOBr nanostructures through a self‐assembly process. Cetyltrimethylammonium bromide (CTAB), which acts as both the bromide source and soft template, plays a critical role in the formation of 3D flowerlike BiOBr nanostructures. Different flowerlike BiOBr nanostructures could be obtained by varying the CTAB concentration. A possible formation process is discussed. The as‐prepared flowerlike BiOBr nanostructures possessed a large surface area and exhibited an excellent removal capacity and fast adsorption rate for CrVI ions in a wide pH range.
Facile Synthesis of Ultrathin AuCu Dimetallic Nanowire Networks
Authors: Shi Lihua , Wang Aiqin , Huang Yanqiang , Chen Xiaowei , Delgado Juan Jose , Zhang Tao 
Published: April 2012

AbstractIn this paper we describe a rapid and effective wet chemical route to the synthesis of netlike AuCu dimetallic nanowires, in which HAuCl4 and Cu(NO3)2 were co‐reduced by NaBH4 in aqueous solution in the presence of surfactant Triton X‐100. The nanowires are composed of homogeneous Au–Cu alloy and possess a uniform diameter of around 3.7 nm. The influence of the experimental parameters – including the concentration of the reducing agent and capping agent, kinds of capping agent, and the ratio of Au/Cu – on the formation of AuCu nanowires have been studied. Among the various parameters investigated, copper was found to play a key role in facilitating the formation of nanowires by means of an oriented attachment mechanism. This method can be further extended to the synthesis of other copper‐containing dimetallic nanowires such as PtCu and PdCu dimetallic nanowire networks.
Microwave‐Assisted Aqueous Synthesis of Small‐Sized, Highly Luminescent CdSeS/ZnS Core/Shell Quantum Dots for Live Cell Imaging
Authors: Zhan Hong‐Ju , Zhou Pei‐Jiang , He Zhen‐Yu , Tian Yuan 
Published: April 2012

AbstractThis study develops a reliable aqueous‐phase method for the synthesis of CdSeS/ZnS core/shell QDs employing microwave irradiation technique. Firstly, CdSeS core QDs were produced by heating a precursor solution containing Cd2+, 3‐mercaptopropionic acid (MPA) and Na2SeSO3 at 130 °C for 30 min. After purification through centrifugation, the CdSeS core QDs were successfully capped with a ZnS shell through heating a capping solution containing Zn2+, S2– and MPA at 100 °C for 1 h. Both the core/shell QDs and core QDs were characterised by X‐ray powder diffraction, transmission electron microscopy and X‐ray photoelectron spectroscopy, and the epitaxial growth of a ZnS shell on the surface of CdSeS QDs was confirmed. The prepared CdSeS/ZnS core/shell QDs showed significantly enhanced luminescence and photostability than that of CdSeS core QDs. Finally, the CdSeS/ZnS core/shell QDs were applied to image live Hela cells. The pilot experiments showed that the cells were successfully stained and exhibited bright green fluorescence. The small size QDs were localised predominantly in the nuclear compartment of Hela cells with negligible cytotoxicity, even at a concentration of 300 μg mL−1 after 24 h incubation. Our results suggest that the new core/shell QDs could be highly biocompatible and have wide applications in biolabelling and imaging.
Magnesium Hydroxide Fluorides – New Materials with Adjustable Composition and Properties
Authors: Scholz Gudrun , Stosiek Christoph , Feist Michael , Kemnitz Erhard 
Published: April 2012

AbstractFluorolytic sol–gel synthesis with aqueous HF results in highly disordered, nanoscopic magnesium hydroxide fluorides with very large BET surface areas, low carbon contents, and adjustable stoichiometries. MgFx(OH)(2–x) materials that can withstand high temperatures can be synthesized in a very wide stoichiometric range by fluorolytic sol–gel synthesis (0 ≤ x ≤ 2). Large surface areas and a very wide range of tunable acid–base properties are characteristic for these compounds, which opens an exciting possibility of their application not only as new catalysts but also as support materials.
Evaluation of a Cognitive Remediation Therapy Group for Adolescents with Anorexia Nervosa: Pilot Study
Authors: Pretorius Natalie , Dimmer Mandy , Power Eoin , Eisler Ivan , Simic Mima , Tchanturia Kate 
Published: April 2012

AbstractObjectiveCognitive remediation therapy (CRT) has been used with adults with anorexia nervosa (AN) in individual and group formats; however, evaluation of CRT with adolescents in this population is very limited.MethodSeven CRT groups were carried out with a total of 30 adolescents with AN. Adolescents' cognitive flexibility and motivation was assessed before and after the group, and they completed qualitative questionnaires after the group to determine their perceptions.ResultsThere was a small effect size in self‐reported cognitive flexibility post group. Adolescents found the group interesting and useful; however, some wanted more support with application to real life.DiscussionCognitive remediation therapy has the potential to be used with adolescents with AN. More research is needed to determine if CRT is beneficial for young people with AN. Copyright © 2012 John Wiley & Sons, Ltd and Eating Disorders Association.
Predicted-no-effect concentrations for the steroid estrogens estrone, 17β-estradiol, estriol, and 17α-ethinylestradiol
Authors: Caldwell Daniel J. , Mastrocco Frank , Anderson Paul D. , Länge Reinhard , Sumpter John P. 
Published: April 2012

Abstract
The authors derive predicted-no-effect concentrations (PNECs) for the steroid estrogens (estrone [E1], 17β-estradiol [E2], estriol [E3], and 17α-ethinylestradiol [EE2]) appropriate for use in risk assessment of aquatic organisms. In a previous study, they developed a PNEC of 0.35 ng/L for EE2 from a species sensitivity distribution (SSD) based on all available chronic aquatic toxicity data. The present study updates that PNEC using recently published data to derive a PNEC of 0.1 ng/L for EE2. For E2, fish were the most sensitive taxa, and chronic reproductive effects were the most sensitive endpoint. Using the SSD methodology, we derived a PNEC of 2 ng/L for E2. Insufficient data were available to construct an SSD for E1 or E3. Therefore, the authors used in vivo vitellogenin (VTG) induction studies to determine the relative potency of the steroid estrogens to induce VTG. Based on the relative differences between in vivo VTG induction, they derive PNECs of 6 and 60 ng/L for E1 and E3, respectively. Thus, for long-term exposures to steroid estrogens in surface water (i.e., &gt;60 d), the PNECs are 6, 2, 60, and 0.1 ng/L for E1, E2, E3, and EE2, respectively. Higher PNECs are recommended for short-term (i.e., a few days or weeks) exposures. Environ. Toxicol. Chem. 2012;31:1396–1406. © 2012 SETAC
Impact of an insecticide changes with amount of leaf litter input: Implications for amphibian populations
Authors: Boone Michelle D. , Sullivan Neal H. 
Published: April 2012

Abstract
Changes in percentage of forest cover can influence nutrient levels in aquatic systems and change abiotic conditions that may influence species. The authors examined how increasing amounts of leaf litter influenced toxicity of the insecticide carbaryl using larval green frogs (Rana clamitans) in outdoor mesocosm ponds. Insecticides can have direct negative effects on individual physiology and behavior and indirect effects on the food web, which can result in trophic cascades. They predicted that direct effects of the insecticide would dominate when nutrients were low (resulting in negative impacts on amphibian development and survival), whereas indirect effects could offset direct effects when nutrients were more abundant through a trophic cascade that leads to more food for tadpoles (resulting in positive effects on amphibian development and survival). The authors found support for this hypothesis: first, total green frog survival was greatest with increased leaf litter input in the presence of carbaryl. Additionally, most green frogs that reached metamorphosis were from ponds with high leaf litter input and carbaryl. Second, the impact of carbaryl on developmental stage and tadpole mass varied depending on the amount of leaf litter present. With high amounts of leaf litter, carbaryl had a positive impact on development and growth; in contrast, with low amounts of leaf litter, carbaryl had negative or no effects on tadpole development and mass. The present study suggests that differences in nutrient levels between ponds exposed to pesticides could play a role in amphibian population dynamics. Environ. Toxicol. Chem. 2012; 31: 1518–1524. © 2012 SETAC
Intensified therapy followed by autologous stem‐cell transplantation (ASCT) versus conventional therapy as first‐line treatment of follicular lymphoma: a meta‐analysis
Authors: Wang Baohong , Ren Cuiai , Zhang Weide , Ma Xiaoyan , Xia Bingsen , Sheng Zhixin 
Published: April 2012

AbstractThere are two different international standards for the treatment of follicular lymphoma (FL): intensified therapy followed by autologous stem‐cell transplantation (ASCT) and conventional therapy in the first‐line setting. However, their role remains unclear. Our aim was to define the treatment effect of intensified therapy followed by ASCT compared with conventional therapy as first‐line treatment of patients with FL in terms of overall survival (OS) and event‐free survival (EFS). We searched for randomised controlled trials in Medline, Embase, the Cochrane controlled trials register and the Science Citation Index (1985 to June 2011). Effect measures used were hazard ratios (HR) for OS, EFS and secondary tumour rate. Two independent review authors extracted data and assessed quality of trials. Four trials were identified, covering a total of 941 subjects. The random‐effects summary HR by comparing the treatment effect on OS between intensified and conventional therapy was 0.95 [0.70, 1.30] (p = 0.75), indicating that no additional survival benefit was derived from the intensified therapy followed by ASCT. A significant benefit of intensified therapy followed by ASCT as first‐line treatment was detected in terms of EFS: the random‐effects summary HR (intensified versus conventional therapy) was 0.59 [0.44, 0.79] (p < 0.001). This meta‐analysis showed that despite its superior EFS, intensified therapy followed by ASCT does not improve the OS compared with conventional therapy. Copyright © 2012 John Wiley & Sons, Ltd.
Controlled Surface Initiated Polymerization of N‐Isopropylacrylamide from Polycaprolactone Substrates for Regulating Cell Attachment and Detachment
Authors: Klein Gunnewiek Michel , Di Luca Andrea , Sui Xiaofeng , van Blitterswijk Clemens A. , Moroni Lorenzo , Vancso G. Julius 
Published: April 2012

AbstractPoly(ε‐caprolactone) (PCL) substrates were modified with thermoresponsive poly(N‐isopropylacrylamide) (PNIPAM) brushes to direct and control cellular attachment and detachment. Prior to brush growth, the surface of PCL was activated by a diamine to allow for initiator coupling. Infrared spectra taken before and after cell culturing demonstrated the covalently attached nature of the PNIPAM brushes. PCL is a biocompatible polymer and to prove that the modifications described above did not change this characteristic property, a cell attachment/detachment study was carried out. The modified substrates showed a lower cell attachment when compared to PCL alone and to PCL films modified with the initiator. The possibility to detach the cells in the form of a sheet was proved using PNIPAM‐modified PCL films by lowering the temperature to 25 °C. No relevant detachment was shown by the unmodified or by the initiator modified surfaces. This confirmed that the detachment was temperature dependent and not connected to other factors such as polymer swelling. These functionalized polymeric films can find applications as smart cell culture systems in regenerative medicine applications.
Microscopic comparative study of the exposure effects of testosterone cypionate and ethinylestradiol during prenatal life on the prostatic tissue of adult gerbils
Authors: Perez Ana P.S. , Biancardi Manoel F. , Vilamaior Patricia S.L. , Góes Rejane M. , Santos Fernanda C.A. , Taboga Sebastião R. 
Published: April 2012

AbstractThere is an increasing variety of endocrine disrupting chemicals (EDCs) either with (anti)estrogenic or (anti)androgenic potential widely present in the environment. These xenosteroids may mimic endogenous steroid hormones disrupting the homeostasis of physiological pathways and leading to several disturbances, especially in tissues highly dependent on steroid hormones such as the prostate. Taking this into account, this comparative study aimed to verify the potential of ethinylestradiol (EE) and testosterone acting as ECDs on the prostate of both male and female adult gerbils exposed to these agents during the embryonic phase. Consequently, pregnant gerbils were treated either with 10 μg/kg/day of EE or with a single dose of 1 mg of testosterone cypionate. The pups that were born 6–8 days after testosterone exposure and the pups that were born after 3 days of EE exposure were allowed to grow but were sacrificed within 4 months. Serological, morphological, stereological, and immunohistochemical analyses were used. Overall, the results showed that both sexes exposed to testosterone and EE during gestation had a prostatic gland with an increased stromal and epithelial and a reduced luminal compartment. Moreover, we observed that glands affected with prostatic intraepithelial neoplasia showed intense stromal reshuffling. In conclusion, although these alterations were observed in both sexes, more relevant to this study was the differential responsiveness of males and females exposed to these different drugs. Whereas the EE affected males more, the testosterone was more harmful to the females. Microsc. Res. Tech. 75:1084–1092, 2012. © 2012 Wiley Periodicals, Inc.