bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transaortic flow velocity from dual‐source MDCT for the diagnosis of aortic stenosis severity
Authors: Schultz Carl J. , Papadopoulou Stella‐Lida , Moelker Adriaan , Nuis Rutger J. , Kate Gert J.R. Ten , Mollet Nico R. , Geleijnse Marcel L. , de Feyter Pim , de Jaegere Peter , Serruys Patrick W. 
Published: June 2011

AbstractObjectives:To describe a method for the estimation of transaortic flow from multidetector computer tomography (MDCT).Background:Cardiac MDCT may not allow instantaneous flow measurement yet the components of flow, namely, volume change over time and lumenal area are recorded.Methods:In 36 patients, the transaortic flow velocity was determined on transthoracic echocardiography and also with cardiac MDCT as follows: On MDCT an axial orientation through the aortic root was obtained so that the nadir of all three aortic leaflets could be seen simultaneously in one axial image. Aortic valve area (AVA) was determined by planimetry and left ventricular volumes by endocardial border mapping at every 5% increment of the RR intervals. Flow velocity was then calculated as the incremental ejection volume ÷ duration of the increment ÷ AVA.Results:The transthoracic echocardiography (TTE) peak velocity and MDCT peak velocity were highly correlated (r = 0.75, P < 0.01). Transaortic peak velocity was higher when measured by MDCT as compared to TTE, with respectively a median [IQ‐range] of 4.5 [2.9–5.3] and 4.0 [3.0–4.6], P < 0.01. For the diagnosis of severe aortic stenosis greater concordance with TTE peak velocity was seen with MDCT peak velocity (sensitivity 100%, specificity 76%) than with MDCT AVA (sensitivity 74%, specificity 76%).Conclusions:We show for the first time that transaortic flow velocity can be estimated by dual‐source MDCT and has a better sensitivity for the detection of severe aortic stenosis than AVA planimetry when compared to the gold standard of TTE peak flow velocity. © 2011 Wiley‐Liss, Inc.
Prognostic role of preprocedural glucose levels on short‐ and long‐term outcome in patients undergoing percutaneous coronary revascularization
Authors: Nusca Annunziata , Patti Giuseppe , Marino Francesco , Mangiacapra Fabio , D'Ambrosio Andrea , Di Sciascio Germano 
Published: June 2011

AbstractObjectives: We investigated the prognostic role of preprocedural blood glucose levels (BGLs) on short‐ and long‐term outcome in patients undergoing elective percutaneous coronary intervention (PCI). Background: Hyperglycemia and hypoglycemia, with or without pre‐existing diabetes mellitus, are associated with adverse outcome in patients with coronary artery disease. Moreover, neointimal hyperplasia after coronary stent implantation is increased in presence of suboptimal glycemic control. Methods: Preprocedural BGLs were prospectively measured in 572 patients and predefined groups were considered: hypoglycemia ≤ 80 mg/dl; euglycemia 81–109 mg/dl; mild hyperglycemia 110–125 mg/dl; hyperglycemia ≥ 126 mg/dl. Primary end point was represented by the incidence of peri‐procedural myocardial infarction (MI) and secondary end point was the occurrence of major adverse cardiac events (MACE) at follow‐up. Results: Hypoglycemia was associated with an increased risk of peri‐procedural MI (51% vs 30%, 29%, and 37% in euglycemia, mild hyperglycemia and hyperglycemia groups, respectively; P for trend 0.025). After a mean follow‐up of 15 ± 8 months, the occurrence of MACE was 38% in the hypoglycemia group, 12% in the euglycemia group, 14% in the mild hyperglycemia and 22% in the hyperglycemia group (P < 0.001). The incidence of in‐stent restenosis and target vessel revascularization was also higher in patients with abnormal pre‐procedural BGLs (P for trend 0.007 and <0.001, respectively). Multivariate analysis confirmed hypoglycemia as a predictor of early and long‐term unfavorable cardiac prognosis (OR = 2.53, 95% CI 1.09‐5.81, P = 0.029 for peri‐procedural MI; OR = 2.91, 95% CI 1.26–6.69, P = 0.012 for MACE occurrence). Conclusions: We observed a significant association between preprocedural BGLs and adverse short‐and long‐term outcome in patients undergoing elective PCI. Thus, a careful glycemic monitoring should be recommended in all patients undergoing coronary stenting, irrespective of the diabetic status. © 2011 Wiley Periodicals, Inc.
Detection of Single Nucleotide Polymorphisms by a Gold Nanowire‐on‐Film SERS Sensor Coupled with S1 Nuclease Treatment
Authors: Yoo Seung Min , Kang Taejoon , Kim Bongsoo , Lee Sang Yup 
Published: June 2011

AbstractSingle nucleotide polymorphisms (SNPs) can serve as important biomarkers for genetic diseases, for which accurate detection of SNPs is essential for early diagnosis. We have developed a novel SNP sensor by combining a Au nanowire‐on‐film surface‐enhanced Raman scattering (SERS) platform with S1 nuclease reaction. The combined sensor system provides reproducible SERS signals only in the presence of perfectly matched target DNAs, to probe DNAs as a result of single‐stranded DNA‐specific degradation by S1 nuclease. Furthermore, point mutations in DNA causing Wilson disease and Avellino corneal dystrophy were successfully identified by this sensor, thereby indicating its practical ability to diagnose genetic diseases.
Studies of Glutathione Transferase P1‐1 Bound to a Platinum(IV)‐Based Anticancer Compound Reveal the Molecular Basis of Its Activation
Authors: Parker Lorien J. , Italiano Louis C. , Morton Craig J. , Hancock Nancy C. , Ascher David B. , Aitken Jade B. , Harris Hugh H. , Campomanes Pablo , Rothlisberger Ursula , De Luca Anastasia , Lo Bello Mario , Ang Wee Han , Dyson Paul J. , Parker Michael W. 
Published: June 2011

AbstractPlatinum‐based cancer drugs, such as cisplatin, are highly effective chemotherapeutic agents used extensively for the treatment of solid tumors. However, their effectiveness is limited by drug resistance, which, in some cancers, has been associated with an overexpression of pi class glutathione S‐transferase (GST P1‐1), an important enzyme in the mercapturic acid detoxification pathway. Ethacraplatin (EA‐CPT), a trans‐PtIV carboxylate complex containing ethacrynate ligands, was designed as a platinum cancer metallodrug that could also target cytosolic GST enzymes. We previously reported that EA‐CPT was an excellent inhibitor of GST activity in live mammalian cells compared to either cisplatin or ethacrynic acid. In order to understand the nature of the drug–protein interactions between EA‐CPT and GST P1‐1, and to obtain mechanistic insights at a molecular level, structural and biochemical investigations were carried out, supported by molecular modeling analysis using quantum mechanical/molecular mechanical methods. The results suggest that EA‐CPT preferentially docks at the dimer interface at GST P1‐1 and subsequent interaction with the enzyme resulted in docking of the ethacrynate ligands at both active sites (in the H‐sites), with the Pt moiety remaining bound at the dimer interface. The activation of the inhibitor by its target enzyme and covalent binding accounts for the strong and irreversible inhibition of enzymatic activity by the platinum complex.
ChemInform Abstract: Nanohybridization of Polyoxometalate Clusters and Single‐Wall Carbon Nanotubes: Applications in Molecular Cluster Batteries.
Authors: Kawasaki Naoya , Wang Heng , Nakanishi Ryo , Hamanaka Shun , Kitaura Ryo , Shinohara Hisanori , Yokoyama Toshihiko , Yoshikawa Hirofumi , Awaga Kunio 
Published: June 2011

Abstract(NBu4)3[PMo12O40] molecules are grafted onto the surface of single‐wall carbon nanotubes by addition of a MeCN solution of the polyoxometalate to a toluene suspension of the nanotubes under vigorous stirring at room temperature.
ChemInform Abstract: Four New Compounds Constructed from Bis‐Antimony‐Capped Keggin Polyoxoanions {PMo12Sb2O40} and Different Coordination Fragments.
Authors: Xiao Li‐Na , Peng Yu , Wang Yan , Xu Jia‐Ning , Gao Zhong‐Min , Liu Ya‐Bing , Zheng Da‐Fang , Cui Xiao‐Bing , Xu Ji‐Qing 
Published: June 2011

AbstractThe structures of the new Sb‐capped Keggin‐type compounds (IV) (triclinic, space group P$\bar 1$, Z = 2), (VI) (orthorhombic, Pccn, Z = 4), (VII) (monoclinic, P21/n, Z = 2), and (VIII) (P$\bar 1$, Z = 1) are determined by single crystal XRD.
ChemInform Abstract: New Quaternary Indides RE7Ni5‐xGe3+xIn6 (RE: La, Nd, Sm).
Authors: Dominyuk Nataliya , Zaremba Vasyl I. , Poettgen Rainer 
Published: June 2011

AbstractLa7Ni4.46Ge3.54In6, Nd7Ni4.91Ge3.09In6, and Sm7Ni4.31Ge3.69In6 are prepared by arc melting of the elements.
ChemInform Abstract: Highly Enantioselective Henry Reaction Catalyzed by C2‐Symmetric Modular BINOL‐Oxazoline Schiff Base Copper(II) Complexes Generated in situ.
Authors: Yang Wen , Du Da‐Ming 
Published: June 2011

AbstractA library of 16 Schiff base copper complexes is generated in situ from four different chiral (2‐aminophenyl)oxazolines, four BINOL‐dicarboxaldehydes, and copper acetate.
ChemInform Abstract: Gold(I)‐Catalyzed Intermolecular [4 + 2] Cycloaddition of Allenamides and Acyclic Dienes.
Authors: Faustino Helio , Lopez Fernando , Castedo Luis , Mascarenas Jose L. 
Published: June 2011

AbstractA variety of polysubstituted cyclohexene derivatives, e.g. (III), (VII), (IX) or (XI), is prepared by highly regio‐ and diastereoselective Au(I)‐catalyzed [4 + 2] cycloaddition of allenamides with acyclic dienes.
ChemInform Abstract: Enantioselective Cyclopropenation of Alkynes with Acceptor/Acceptor‐Substituted Diazo Reagents via Co(II)‐Based Metalloradical Catalysis.
Authors: Cui Xin , Xu Xue , Lu Hongjian , Zhu Shifa , Wojtas Lukasz , Zhang X. Peter 
Published: June 2011

AbstractThe new Co complex (I) efficiently promotes the asymmetric cyclopropenation of various aromatic and conjugated alkynes with diazo compounds.
ChemInform Abstract: Ring‐Contraction Strategy for the Practical, Scalable, Catalytic Asymmetric Synthesis of Versatile γ‐Quaternary Acylcyclopentenes.
Authors: Hong Allen Y. , Krout Michael R. , Jensen Thomas , Bennett Nathan B. , Harned Andrew M. , Stoltz Brian M. 
Published: June 2011

AbstractEnantioselective decarboxylative internal allylation of esters (I) followed by hydride reduction and base‐promoted ring contraction of the intermediate cyclic β‐hydroxy ketones affords densely functionalized chiral acylcyclopentenes.
ChemInform Abstract: Iron Powder‐CuI Cooperative Catalytic System in Sonogashira Cross‐Coupling Reaction.
Authors: Tran Ngoc Thang , Cho Chan Sik , Sohn Ho‐Sang , Shim Sang Chul 
Published: June 2011

AbstractA cheaper cooperative catalytic system in Sonogashira cross‐coupling reactions of aryl‐, vinyl‐, alkyl‐substituted terminal alkynes with aryl iodides is presented.
ChemInform Abstract: Stereospecific Copper‐Catalyzed C—H Allylation of Electron‐Deficient Arenes with Allyl Phosphates.
Authors: Yao Tomoyuki , Hirano Koji , Satoh Tetsuya , Miura Masahiro 
Published: June 2011

AbstractIt is detailed, that the Cu(acac)2/phen system allows the efficient direct C—H allylation of polyfluoroarenes with allyl phosphates where the stereochemical information of the allyl phosphate is retained.
ChemInform Abstract: A Versatile Protocol for Copper‐Catalyzed Cyanation of Aryl and Heteroaryl Bromides with Acetone Cyanohydrin.
Authors: Schareina Thomas , Zapf Alexander , Cotte Alain , Gotta Matthias , Beller Matthias 
Published: June 2011

AbstractThe alternative method allows a precise control of the critical cyanide concentration in solution by variation of the dosage rate.
ChemInform Abstract: Room‐Temperature Nickel‐Catalyzed Suzuki—Miyaura Reactions of Aryl Sulfonates/Halides with Arylboronic Acids.
Authors: Fan Xin‐Heng , Yang Lian‐Ming 
Published: June 2011

AbstractThe air‐stable Ni(II)—(σ‐aryl) complex NIC in conjunction with monophosphane ligands efficiently catalyzes the cross‐coupling of arylsulfonates (OTos, OMes) and/or halides (Cl, Br, I).
ChemInform Abstract: Highly Diastereoselective Iron‐Mediated C(sp2)—C(sp3) Cross‐Coupling Reactions Between Aryl Grignard Reagents and Cyclic Iodohydrine Derivatives.
Authors: Steib Andreas K. , Thaler Tobias , Komeyama Kimihiro , Mayer Peter , Knochel Paul 
Published: June 2011

AbstractThe process provides the trans products with excellent diastereoselectivity.
ChemInform Abstract: Pd Nanoparticles on a Porous Ionic Copolymer: A Highly Active and Recyclable Catalyst for Suzuki—Miyaura Reaction under Air in Water.
Authors: Yu Yanpeng , Hu Tongjie , Chen Xiaorong , Xu Kunling , Zhang Junli , Huang Jun 
Published: June 2011

AbstractA copolymer of vinylimidazolium acetic acid and divinylbenzene is prepared and applied as a support for Pd nanoparticles.
ChemInform Abstract: Carbon‐Based Solid Acid Catalyzed One‐Pot Mannich Reaction: A Facile Synthesis of β‐Amino Carbonyl Compounds.
Authors: Davoodnia Abolghasem , Tavakoli‐Nishaburi Afsaneh , Tavakoli‐Hoseini Niloofar 
Published: June 2011

AbstractThe three‐component condensation of acetophenone (I), aromatic aldehydes (II), and aromatic amines (III) in the presence of catalytic amounts of carbon‐based solid acid affords the title compounds (IV) in high yields.
ChemInform Abstract: Efficient Synthesis and Practical Resolution of 1‐(Naphthalen‐1‐yl)ethanamine, a Key Intermediate for Cinacalcet.
Authors: Mathad Vijayavitthal T. , Shinde Gorakshanath B. , Ippar Sharad S. , Niphade Navnath C. , Panchangam Raghavendra K. , Vankawala Pravinchandra J. 
Published: June 2011

AbstractA synthesis suitable for large‐scale production is given for the hydrochloride salt of (R)‐1‐(naphthalen‐1‐yl)ethanamine (V), which is a key intermediate in the synthesis cinacalcet hydrochloride, a drug for the treatment of secondary hyperparathyroidism.
ChemInform Abstract: Broensted Acidic Ionic Liquids as Efficient Catalysts for Clean Synthesis of Carbamatoalkyl Naphthols.
Authors: Tavakoli‐Hoseini Niloofar , Heravi Majid M. , Bamoharram Fatemeh F. , Davoodnia Abolghasem 
Published: June 2011

AbstractA catalytic method for the synthesis of the title compounds (IV) (15 examples) by one‐pot condensation of aromatic aldehydes, β‐naphthol and carbamates using Broensted‐acidic ionic liquids as efficient, reusable, and eco‐friendly homogeneous catalysts is presented.
ChemInform Abstract: Three‐Component Synthesis of Ynediones by a Glyoxylation/Stephens—Castro Coupling Sequence.
Authors: Merkul Eugen , Dohe Janis , Gers Charlotte , Rominger Frank , Mueller Thomas J. J. 
Published: June 2011

AbstractThe synthesis of ynediones is achieved through acylation of hetarenes and azulene with oxalyl chloride and subsequent CuI‐catalyzed Stephens—Castro coupling in one‐pot.
ChemInform Abstract: A Flow Chemistry Route to 2‐Phenyl‐3‐(1H‐pyrrol‐2‐yl)propan‐1‐amines.
Authors: Tarleton Mark , McCluskey Adam 
Published: June 2011

AbstractRaney‐Ni catalyzed flow hydrogenation of α,β‐unsaturated nitriles in methanol provides the title compounds (II), whereas Pd‐C in acetone allows the selective reduction of the olefin double bond to give the saturated nitrile (III).
ChemInform Abstract: Synthesis of 3‐Arylindole‐2‐carboxylates via Copper‐Catalyzed Hydroarylation of o‐Nitrophenyl‐Substituted Alkynoates and Subsequent Cadogan Cyclization.
Authors: Yamamoto Yoshihiko , Yamada Satoshi , Nishiyama Hisao 
Published: June 2011

AbstractA two‐step route to biologically important arylindole carboxylic esters is successfully established.
ChemInform Abstract: Synthesis and Biological Activity of 2‐(Bis((1,3,4‐oxadiazolyl/1,3,4‐thiadiazolyl)methylthio)methylene) malonitriles.
Authors: Padmavathi V. , Reddy G. Dinneswara , Reddy S. Nagi , Mahesh K. 
Published: June 2011

AbstractSynthesized compounds (IV) are tested for antimicrobial and antioxidant activities.
ChemInform Abstract: Iodocyclization versus Diiodination in the Reaction of 3‐Alkynyl‐4‐methoxycoumarins with Iodine: Synthesis of 3‐Iodofuro[2,3‐b]chromones.
Authors: Raffa Guillaume , Belot Sebastien , Balme Genevieve , Monteiro Nuno 
Published: June 2011

AbstractThe iodocyclization of alkynylmethoxycoumarins (I) and (III) proceeds smoothly at reflux temperature to give iodofurocoumarins (II) and (IV), respectively.
ChemInform Abstract: NMR Evidence of the Kinetic and Thermodynamic Products in the NIS Promoted Cyclization of 1‐Phenyl‐4‐pentenylamines. Synthesis and Reactivity of trans‐2‐Phenyl‐5‐iodopiperidines.
Authors: Diaba Faiza , Bonjoch Josep 
Published: June 2011

AbstractA straightforward method for the synthesis of 5‐iodo‐2‐phenylpiperidines by iodoaminocyclization of 1‐phenylpentenamines is developed.
ChemInform Abstract: Design, Synthesis and Evaluation of Substituted N‐(3‐Arylpropyl)‐9,10‐dihydro‐9‐oxoacridine‐4‐carboxamides as Potent MDR Reversal Agents in Cancer.
Authors: Velingkar V. S. , Dandekar V. D. 
Published: June 2011

AbstractA variety of new acridine‐4‐carboxamides (VII) and (IX) is designed, synthesized by a novel route and evaluated for their inhibitory effects on the transport activity of P‐glycoprotein.
ChemInform Abstract: Synthesis of 2,2‐Disubstituted Azaindolines by Intramolecular Cyclization in Acidic Media.
Authors: Metro Thomas‐Xavier , Fayet Christine , Arnaud Florian , Rameix Nathalie , Fraisse Pierre , Janody Simon , Sevrin Mireille , George Pascal , Vogel Rachel 
Published: June 2011

AbstractAcidic treatment of various aminopyridine substrates bearing a hydroxyalkyl or alkenyl substituent at the ortho‐position of the amino‐group offers a simple method to synthesize the required building blocks.
ChemInform Abstract: One‐Pot Multistep Synthesis of 3,4‐Fused Isoquinolin‐1(2H)‐one Analogues.
Authors: Li Lianhai , Chua Waepril Kimberly S. 
Published: June 2011

AbstractBenzonitriles or nicotinonitriles bearing a ‐OH, ‐SH, or ‐NHR substituent are easily alkylated at the respective heteroatom with ester (I).
ChemInform Abstract: Triazole Incorporated Pyridazinones as a New Class of Antihypertensive Agents: Design, Synthesis and in vivo Screening.
Authors: Siddiqui Anees A. , Mishra Ravinesh , Shaharyar Mohammad , Husain Asif , Rashid Mohd. , Pal Palash 
Published: June 2011

AbstractCarbohydrazide derivatives (II) react with aryl isothiocyanates (III) to afford the corresponding thiosemicarbazides which are cyclized to the final compounds (IV) by treatment with sodium hydroxide solution.
ChemInform Abstract: A Facile and Rapid Synthesis of N‐Benzyl‐2‐substituted Piperazines.
Authors: Jida Mouhamad , Soueidan Mohamad , Willand Nicolas , Agbossou‐Niedercorn Francine , Pelinski Lydie , Laconde Guillaume , Deprez‐Poulain Rebecca , Deprez Benoit 
Published: June 2011

AbstractA straightforward synthesis of the biologically interesting core structures is achieved through microwave‐promoted cyclocondensation of easily prepared Ugi products (II).
ChemInform Abstract: Improved One‐Pot Synthesis of C3‐Symmetric ClickPhos and Related Ligands: Structures of Unique Triazole—Zinc Complexes.
Authors: Zink Daniel M. , Baumann Thomas , Nieger Martin , Braese Stefan 
Published: June 2011

AbstractMono‐, bis‐, and tris(triazolyl)phosphanes are prepared by in three steps without isolation of the intermediates.
ChemInform Abstract: Selective Base‐Promoted Synthesis of Substituted Selenophenes by Carbocyclization of (Z)‐Benzylselenoenynes.
Authors: Barancelli Daniela A. , Acker Carmine I. , Menezes Paulo H. , Zeni Gilson 
Published: June 2011

AbstractHydroselenation of diaryldiynes (II) with dibenzyl diselenides (I) affords benzylselenoenynes (III) which smoothly undergo cyclization in the presence of the strong base tBuOK to give 3‐benzyl‐2,5‐diaryls selenophenes (IV).
ChemInform Abstract: Synthesis and Antiinflammatory Activity of ent‐Kaurene Derivatives.
Authors: Hueso‐Falcon Idaira , Cuadrado Irene , Cidre Florencia , Amaro‐Luis Juan M. , Ravelo Angel G. , Estevez‐Braun Ana , de las Heras Beatriz , Hortelano Sonsoles 
Published: June 2011

AbstractA series of kaurene derivatives is synthesized and evaluated for their ability to suppress NO production in LPS‐stimulated RAW 264.7 macrophages.
ChemInform Abstract: A New Ursane‐Type Triterpenoid Glycoside (I) from Centella asiatica Leaves Modulates the Production of Nitric Oxide and Secretion of TNF‐α in Activated RAW 264.7 Cells.
Authors: Kim Young Ho , et al. et al. 
Published: June 2011

AbstractThe new ursane‐type triterpenoid glycoside, asiaticoside G (I), is isolated along with five known triterpenoids and four flavonoids from the leaves of Centella asiatica. Their chemical structures are elucidated and bioactivities are evaluated.
ChemInform Abstract: A Biomimetic Approach to the Cylindrospermopsin Alkaloids.
Authors: Evans Daniel M. , Murphy Patrick J. 
Published: June 2011

AbstractA tethered Biginelli condensation of hemiaminal derived from compound (I) with β‐keto ester (II) provides access to the tricyclic guanidine moiety found in cylindrospermin alkaloids.
ChemInform Abstract: A Non‐Iterative, Flexible, and Highly Stereoselective Synthesis of Polydeoxypropionates — Synthesis of (+)‐Vittatalactone.
Authors: Weise Christian F. , Pischl Matthias , Pfaltz Andreas , Schneider Christoph 
Published: June 2011

AbstractTrideoxypropionates (V) and (VII) are prepared via a short sequence involving an oxy‐Cope rearrangement, iridium‐catalyzed hydrogenation, and enolate methylation.
ChemInform Abstract: Antioxidant Xanthone Derivatives Induce Cell Cycle Arrest and Apoptosis and Enhance Cell Death Induced by Cisplatin in NTUB1 Cells Associated with ROS.
Authors: Cheng Jen‐Hao , Huang A‐Mei , Hour Tzyh‐Chyuan , Yang Shyh‐Chyun , Pu Yeong‐Shiau , Lin Chun‐Nan 
Published: June 2011

AbstractA series of novel xanthone derivatives (I) is prepared and screened for inhibitory effects on xanthine oxidase and ABTS radical‐ion scavenging activity.
ChemInform Abstract: Ferrocene—Indole Hybrids for Cancer and Malaria Therapy
Authors: Quirante Josefina , Dubar Faustine , Gonzalez Asensio , Lopez Concepcion , Cascante Marta , Cortes Roldan , Forfar Isabelle , Pradines Bruno , Biot Christophe 
Published: June 2011

AbstractReview: 58 refs.
Blueprint of an ancestral neurosensory organ revealed in glial networks in human dental pulp
Authors: Farahani Ramin M. , Simonian Mary , Hunter Neil 
Published: June 2011

AbstractSensory function of human dental pulp has long been known. A composite role has been suggested for odontoblasts as sensory cells in addition to the synthesis of dentinal matrix. However, the neural basis for such a composite sensory activity remains enigmatic. Here, we aimed to probe the question by pursuing an evolutionary logic; if dental pulp is a vestigial sensory organ co‐opted to a function of synthesis of mineralized matrix, essential elements of neurosensory organs may persist in dental pulp. Through structural analysis by confocal laser scanning microscopy, three distinct cell populations adjacent to odontoblasts, glial fibrillary acidic protein (GFAP)+ seracytes, S100+ telacytes, and HLA‐II+ alacytes were identified in peripheral human dental pulp. Subsequent molecular fingerprinting by quantitative reverse transcriptase‐polymerase chain reaction established these cells as analogous to radial glia (GFAP+ cells), astrocytes (S100+ cells), and microglia (HLA‐II+ cells) of central nervous system organs. In the cell‐rich zone of the pulp, S100+ cells formed a network, ensheathed unmyelinated axons, and extended end‐feet around the capillaries. The microcirculation adjacent to the glial cells in the cell‐rich zone possessed ultrastructural features and a gene expression profile typical of the blood‐brain barrier system. These novel findings support a new paradigm for understanding sensory functionality of dental pulp by the demonstration of a sophisticated neural structure in the human dental pulp that is analogous to other central sensory organs. Further, the structure that is revealed informs the concept of the evolutionary origin of the dental pulp, suggesting that a neurosensory organ was the precursor structure of teeth. J. Comp. Neurol.519:3306–3326, 2011. © 2011 Wiley‐Liss, Inc.