bluuebunny/crossref_metadata_2025_split huggingface dataset:
Different patterns of bone fixation with hydroxyapatite and resorbable CaP coatings in the rabbit tibia at 6, 12, and 52 weeks
Authors: Reigstad Ole , Johansson Carina , Stenport Victoria , Wennerberg Ann , Reigstad Astor , Røkkum Magne 
Published: June 2011

AbstractApplying bioactive coatings on orthopedic implants can increase the fixation and long‐term implant survival. In our study, we compared a resorbable electrochemically deposited calcium phosphate coating (Bonit®) to a thin (40 μm) plasma‐sprayed hydroxyapatite (HA) coating, applied on grit‐blasted screw‐shaped Ti‐6Al‐4V implants in the cortical region of rabbit tibia, implanted for 6, 12, and 52 weeks. The removal torque results demonstrated stronger bone‐to‐implant fixation for the HA than Bonit‐coated screws at 6 and 12 weeks. After 52 weeks, the fixation was in favor of the Bonit‐coated screws, but the difference was statistically insignificant. Coat flaking and delamination of the HA with multinucleated giant cell activity and bone resorption observed histologically seemed to preclude any significant increase in fixation comparing the HA implants at 6 versus 12 weeks and 12 versus 52 weeks. The Bonit‐coated implants exhibited increasing fixation from 6 to 12 weeks and from 12 to 52 weeks, and the coat was resorbed within 6 weeks, with minimal activity of multinucleated giant cells or bone resorption. A different fixation pattern was observed for the two coatings with a sharper but time limited increase in fixation for the HA‐coated screws, and a slower but more steadily increasing fixation pattern for the Bonit‐coated screws. The side effects were more serious for the HA coating and limiting the expected increase in fixation with time. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.
Indexing molecules with chemical graph identifiers
Authors: Gregori‐Puigjané Elisabet , Garriga‐Sust Rut , Mestres Jordi 
Published: June 2011

AbstractFast and robust algorithms for indexing molecules have been historically considered strategic tools for the management and storage of large chemical libraries. This work introduces a modified and further extended version of the molecular equivalence number naming adaptation of the Morgan algorithm (J Chem Inf Comput Sci 2001, 41, 181‐185) for the generation of a chemical graph identifier (CGI). This new version corrects for the collisions recognized in the original adaptation and includes the ability to deal with graph canonicalization, ensembles (salts), and isomerism (tautomerism, regioisomerism, optical isomerism, and geometrical isomerism) in a flexible manner. Validation of the current CGI implementation was performed on the open NCI database and the drug‐like subset of the ZINC database containing 260,071 and 5,348,089 structures, respectively. The results were compared with those obtained with some of the most widely used indexing codes, such as the CACTVS hash code and the new InChIKey. The analyses emphasize the fact that compound management activities, like duplicate analysis of chemical libraries, are sensitive to the exact definition of compound uniqueness and thus still depend, to a minor extent, on the type and flexibility of the molecular index being used. © 2011 Wiley Periodicals, Inc. J Comput Chem, 2011
Combining a polarizable force‐field and a coarse‐grained polarizable solvent model. II. Accounting for hydrophobic effects
Authors: Masella Michel , Borgis Daniel , Cuniasse Philippe 
Published: June 2011

AbstractA revised and improved version of our efficient polarizable force‐field/coarse grained solvent combined approach (Masella, Borgis, and Cuniasse, J. Comput. Chem. 2008, 29, 1707) is described. The polarizable pseudo‐particle solvent model represents the macroscopic solvent polarization by induced dipoles placed on mobile pseudo‐particles. In this study, we propose a new formulation of the energy term handling the nonelectrostatic interactions among the pseudo‐particles. This term is now able to reproduce the energetic and structural response of liquid water due to the presence of a hydrophobic spherical cavity. Accordingly, the parameters of the energy term handling the nonpolar solute/solvent interactions have been refined to reproduce the free‐solvation energy of small solutes, based on a standard thermodynamic integration scheme. The reliability of this new approach has been checked for the properties of solvated methane and of the solvated methane dimer, as well as by performing 10 × 20 ns molecular dynamics (MD) trajectories for three solvated proteins. A long‐time stability of the protein structures along the trajectories is observed. Moreover, our method still provides a measure of the protein solvation thermodynamic at the same accuracy as standard Poisson–Boltzman continuum methods. These results show the relevance of our approach and its applicability to massively coupled MD schemes to accurately and intensively explore solvated macromolecule potential energy surfaces. © 2011 Wiley Periodicals, Inc. J Comput Chem, 2011
Gradients for configuration interaction energies with spin‐orbit coupling in a semiempirical framework
Authors: Granucci Giovanni , Persico Maurizio 
Published: June 2011

AbstractWe present a method for the analytical evaluation of the molecular energy gradient for a semiempirical configuration interaction (CI) wavefunction, taking into account the spin‐orbit coupling. We show how to proceed in the simplest case where all the wavefunctions belonging to the CI subspace considered are mixed by the spin‐orbit interaction, and we develop an original procedure for the more complex case where only a limited number of CI eigenvectors of the spin‐free Hamiltonian are mixed. © 2011 Wiley Periodicals, Inc. J Comput Chem, 2011
Theoretical study on the unimolecular decomposition of thiophenol
Authors: Al‐Muhtaseb Ala'a H. , Altarawneh Mohammednoor , Almatarneh Mansour H. , Poirier Raymond A. , Assaf Niveen W. 
Published: June 2011

AbstractThe potential energy surface for the unimolecular decomposition of thiophenol (C6H5SH) is mapped out at two theoretical levels; BB1K/GTlarge and QCISD(T)/6‐311+G(2d,p)//MP2/6‐31G(d,p). Calculated reaction rate constants at the high pressure limit indicate that the major initial channel is the formation of C6H6S at all temperatures. Above 1000 K, the contribution from direct fission of the SH bond becomes important. Other decomposition channels, including expulsion of H2 and H2S are of negligible importance. The formation of C6H6S is predicted to be strong‐pressure dependent above 900 K. Further decomposition of C6H6S produces CS and C5H6. Overall, despite the significant difference in bond dissociation, i.e., 8‐9 kcal/mol between the SH bond in thiophenol and the OH bond in phenol, H migration at the ortho position in the two molecules represents the most accessible initial channel. © 2011 Wiley Periodicals, Inc. J Comput Chem, 2011
The psychotherapy of psychotherapists
Authors: Geller Jesse D. 
Published: June 2011

AbstractThis article introduces a special issue of the Journal of Clinical Psychology: In Session that provides 6 psychologists' narrative accounts of their own personal therapies and a practice‐friendly research review on the characteristics of therapist‐patients and their own treatment experiences. In response to a standard set of questions, highly experienced psychotherapists hailing from diverse theoretical commitments wrote the accounts. Their accounts illuminate subtle nuances of the therapeutic relationship and treatment outcome, perhaps more fully than other sources of data. Much of value can be learned from these essays and the research findings about the linkages between receiving and conducting psychotherapy and about the technical and emotional challenges that arise when treating a patient who shares the same profession. © 2011 Wiley Periodicals, Inc. J Clin Psychol: In Session 67:1–7, 2011.
My experience with psychotherapy, existential analysis and Jungian analysis: Rollo May and beyond
Authors: Keddy Philip 
Published: June 2011

AbstractThis article describes my initial psychotherapy experience with a psychologist who combined a client‐centered/rational‐emotive approach, my existential analysis with Rollo May, and then concludes briefly portraying my current Jungian analysis. I explain how I came to each of these experiences, what I learned from them, and the limitations I have recognized in them. I elaborate on the existential analysis with Rollo May, as it marked a major turning point in my life and thinking. I have been able to describe that experience with the benefit of hindsight, which I do not have with the Jungian analysis. In closing, I offer some suggestions about the role of therapy/analysis in the training of the psychotherapist. © 2011 Wiley Periodicals, Inc. J Clin Psychol: In Session 67:1–12, 2011.
A case of isolated congenital ductus arteriosus aneurysm detected by fetal echocardiography at 38 weeks of gestation
Authors: Oh Sae Jeong , Jeung In Cheul 
Published: June 2011

AbstractA 30 year‐old pregnant woman (G1P0) was diagnosed with fetal ductus arteriosus aneurysm (DAA) at 38 weeks of gestation. The three‐vessel view of the heart and the sagittal view of the ductal arch showed a 12‐mm fusiform dilatation of the ductus arteriosus. Turbulent flow was detected in it by color Doppler. DAA was confirmed by postnatal echocardiography within 24 hours after birth and it spontaneously closed in the neonatal period. Congenital DAA, usually developed in the third trimester, is potentially fatal due to the possible complications such as spontaneous rupture, dissection, and thromboembolism. © 2011 Wiley Periodicals, Inc. J Clin Ultrasound, 2011
Contrast‐enhanced sonographic diagnosis of unsuspected internal iliac vein thrombosis
Authors: de Perrot Thomas , Righini Marc , Bounameaux Henri , Poletti Pierre‐Alexandre 
Published: June 2011

AbstractWe report a rare case of an isolated and unsuspected thrombosis in the right internal iliac vein. The presentation was atypical with regard to the clinical manifestations and the thrombus location. The patient was admitted for an acute abdominal pain in the right iliac fossa. The thrombosis was suspected on the basis of a portal‐phase contrast‐enhanced abdominal CT but the lack of a delayed phase did not allow confirmation. Contrast‐enhanced ultrasound confirmed the diagnosis, by displaying a well‐defined filling defect. © 2011 Wiley Periodicals, Inc. J Clin Ultrasound, 2011;
Cesarean scar pregnancy: A rare cause of uterine arteriovenous malformation
Authors: Akbayir Ozgur , Gedikbasi Ali , Akyol Alpaslan , Ucar Adem , Saygi‐Ozyurt Sezin , Gulkilik Ahmet 
Published: June 2011

AbstractA 38‐year‐old gravida 4, para 2 woman with a history of two Cesarean sections and one curettage was referred to our hospital, because of painless vaginal bleeding and 6 weeks + 2 days of amenorrhea. The first diagnosis was Cesarean scar pregnancy, managed with methotrexate. Subsequently, an arteriovenous malformation developed, which was diagnosed with color Doppler imaging. The diagnosis was confirmed with angiography. Successful bilateral uterine artery embolization was performed with ethylene vinyl alcohol copolymer (Onyx), n‐butyl‐2‐cyanoacrylate (Histoacryl), and gelfoam. © 2011 Wiley Periodicals, Inc. J Clin Ultrasound, 2011
Synaptic failure and adenosine triphosphate imbalance induced by amyloid‐β aggregates are prevented by blueberry‐enriched polyphenols extract
Authors: Fuentealba Jorge , Dibarrart Andrea J. , Fuentes‐Fuentes Maria Cecilia , Saez‐Orellana Francisco , Quiñones Karin , Guzmán Leonardo , Perez Claudia , Becerra Jose , Aguayo Luis G. 
Published: June 2011

AbstractThe potential neuroprotective properties of fruits have been widely recognized. In this study, we evaluated the protective properties of a blueberry extract (BB‐4), rich in polyphenols, in a neurodegenerative model induced by amyloid‐β peptide (Aβ). Chronic treatment with Aβ drastically reduced synaptic transmission and the extent of secretory vesicles, which were recovered partially with BB‐4. Also, the extract recovered Ca2+ transients in hippocampal neurons preincubated with Aβ (0.5 and 5 μM) by about 25% ± 3% and 30% ± 2, respectively. In this work, we demonstrate a novel effect of the BB‐4 extract on Aβ‐induced ATP leakage, in which this extract was able to antagonize the acute ATP leakage but not chronic ATP depletion. On the other hand, BB‐4 prevented the uncoupling of mitochondrial function induced by FCCP by about 85%, but it was unable to modify the uncoupling induced by Aβ. The present results strongly indicate that BB‐4 plays a role in the process of Aβ aggregation by reducing the toxic species (i.e., 40 kDa). These findings suggest that a blueberry extract can protect neuronal tissue from Aβ toxicity mainly through its antiaggregation property, and its antioxidant properties and mitochondrial membrane potential capacities are secondary mechanisms important in chronic stages. Our work suggests that BB‐4 could be an important nutritional complement to neuronal health as well as a potential nutraceutical formulation useful as a dietary supplement in the elderly. © 2011 Wiley‐Liss, Inc.
Brain‐derived neurotrophic factor modulates antiretroviral‐induced mechanical allodynia in the mouse
Authors: Renn Cynthia L. , Leitch Carmen C. , Lessans Sherrie , Rhee Peter , McGuire W. Cameron , Smith Barbara A. , Traub Richard J. , Dorsey Susan G. 
Published: June 2011

AbstractNucleoside reverse transcriptase inhibitors (NRTIs) are key components of HIV/AIDS treatment to reduce viral load. However, these drugs can induce chronic neuropathic pain, leading to increased morbidity in HIV patients. This study examines the role of brain‐derived neurotrophic factor (BDNF) in the spinal dorsal horn (SDH) in development of mechanical allodynia in male C57BL/6J mice treated with the NRTI stavudine (d4T). After d4T administration, mice developed increased neuronal activity and BDNF expression in the SDH and hind paw mechanical allodynia that was exacerbated by intrathecal BDNF administration. Intrathecal BDNF alone also increased neuronal activity and caused mechanical allodynia. Because excess BDNF amplified d4T‐induced mechanical allodynia and neuronal activity, the impact of decreasing BDNF in the SDH was investigated. After d4T, BDNF heterozygous mice were less allodynic than wild‐type littermates, which was negated by intrathecal BDNF administration. Finally, pretreatment with intrathecal trkB‐Fc chimera prior to d4T or administration of the tyrosine kinase inhibitor K252a 3 days after d4T blocked BDNF‐mediated signaling, significantly attenuated the development of mechanical allodynia (trkB‐Fc), and decreased neuronal activity (trkB‐Fc and K252a). Taken together, these findings provide evidence that BDNF in the SDH contributes to the development of NRTI‐induced painful peripheral neuropathy and may represent a new therapeutic opportunity. © 2011 Wiley‐Liss, Inc.
Influence of cloudiness on sunshine duration
Authors: Matuszko Dorota 
Published: June 2011

AbstractThis paper analyzes the influence of cloudiness and cloud genera on sunshine duration based on a very long (1884–2007) homogeneous daily nephological and sunshine duration data series for the City of Krakow. Quadratic regression was used to describe the relationship between sunshine duration and cloudiness. It has been shown that cloudiness affects sunshine duration the most in June and July, and the least in December, January and February. High clouds (Cirrus, Cirrostratus, Cirrocumulus) do not interrupt the recording of sunshine duration even when they completely cover the sky. Layered clouds such as Stratus and Nimbostratus, on the other hand, do not transmit solar radiation at all. The degree of influence of different cloud genera on sunshine duration changes very little from season to season and with respect to the position of the Sun over the horizon. When the Sun is positioned higher over the horizon, clouds are less able to weaken solar radiation, resulting in larger sunshine duration values. This is especially true with respect to the following clouds: Cirrus, Cirrostratus and Cumulus. It has been shown that daytime sunshine duration patterns can be a very good indicator of cloud type and cloudiness variability. Copyright © 2011 Royal Meteorological Society
Characteristic features of hourly rainfall in India
Authors: Deshpande N. R. , Kulkarni A. , Krishna Kumar K. 
Published: June 2011

AbstractHourly rainfall data recorded at 72 Self Recording Raingauge Stations (SRRG) for the period 1969–2006 are utilized to study the characteristic features of hourly rainfall and diurnal variations of rainfall in India. Temporal changes in the short duration (less than 12 h) rainfall extremes are examined. Time distribution of a heavy rain spell of 24 h duration, which is an important component in water resources management and flood control studies, is analysed. Different aspects of hourly rainfall such as, average number of rain hours in a year, empirical probability distribution functions have also been examined. Analysis indicates, many stations in India have recorded more than 10 cm of rainfall in an hour's duration. Such stations are located along the west coast, foothills of Himalayas and along the tracks of monsoon disturbances. Extreme rainfall events of various duration (3–12 h) show increasing trends, significant at 5% level, at many stations located in central India and peninsular India except for southern part of west coast. Time distribution of hourly rainfall shows that, on average, 25% of the daily rainfall can be received in just 3 h, while 80% can occur in 12 h during the heavy rain spells of 24‐h duration. Copyright © 2011 Royal Meteorological Society
Comparative analysis of serum proteomes of degenerative scoliosis
Authors: Zhu Yong , Han Shijie , Zhao Hong , Liang Jinqian , Zhai Jiliang , Wu Zhihong , Qiu Guixing 
Published: June 2011

AbstractDegenerative scoliosis (DS) is an important degenerative lumbar disease causing spinal dysfunction and affecting the quality of life of the elderly, and is associated not only with severe back or leg pain but also with complicated surgical outcomes. The pathogenesis of DS is still unknown. Therefore, it is very important to ascertain the etiology of degenerative scoliosis and establish related molecular markers predicting and controlling the scoliosis. For the first time, we used two‐dimensional fluorescence DIGE to compare the serum proteome profiles of 12 DS patients and controls. Proteins found to be differentially expressed were identified by MALDI‐TOF mass spectrometric analysis, coupled with database interrogation. Eleven spots that were differentially expressed in the sera of DS patients were found, and eight gene products were identified among these spots. Clusterin, CLU cDNA FLJ57622, ALB cDNA FLJ50830, Hypothetical short protein, HLA‐A MHC class 1 antigen. (Fragment), ALB 23 kDa protein, Isoform 1 of G protein‐regulated inducer of neurite outgrowth 1 (GPRIN I)and Ficolin‐3 were down‐regulated in the sera of DS patients. The decreased levels of Clusterin and Ficolin‐3 were confirmed by Western blot. The information obtained with this proteomic analysis will be very useful in understanding the pathophysiology of DS as well as in finding candidates as drug targets of DS. These results may provide a novel approach for the pathogenesis study of DS. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 29:1896–1903, 2011
Biomechanical examination of the thoracic spine—the axial rotation moment and vertical loading capacity of the transverse process
Authors: Csernátony Zoltán , Molnár Szabolcs , Hunya Zsolt , Manó Sándor , Kiss László 
Published: June 2011

AbstractOur objective was to examine the load‐bearing capacity of the transverse processes of human cadaveric thoracic vertebrae to vertical loads and axial rotation moments (i.e., moment applied in the transverse plane). A secondary objective was to examine the effect of the attached rib stumps. We wanted to demonstrate that the transverse process is durable enough to support the CAB hook—a complementary hook to the CD system—and can handle the vertical load or axial rotation moment during correction of scoliosis. We used 107 thoracic vertebrae removed from 10 cadavers. They were prepared in vertebral pairs, and were fixed into a material testing apparatus. Superoinferior vertical loads and axial rotation moments were applied to the transverse process using the CAB hooks at a rate of 30 mm/min and 8.5°/s respectively until it fractured. We recorded 142 measurements, 99 were for vertical load and 43 for axial rotation moment. The average ultimate vertical load was 338 (SD = 128) N and the average ultimate axial rotation moment was 14.4 (SD = 4.52) Nm. The ultimate axial rotation moment for specimens with rib stumps attached was significantly greater than for specimens without rib stumps 15.9 (SD = 4.1) Nm versus 12.5 (SD = 4.4) Nm. Our results showed that both the vertical and axial rotation loading capability of the transverse process are large enough to withstand significant correctional forces, without fracture, through the CAB hooks. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 29:1904–1909, 2011
Liquid chromatography‐mass spectrometric method for determination of the non‐imidazole H3‐receptor antagonist UPR1056 in rat plasma
Authors: Vacondio Federica , Silva Claudia , Morini Giovanni , Bordi Fabrizio , Flammini Lisa , Barocelli Elisabetta , Mor Marco 
Published: June 2011

AbstractThe non‐imidazole H3 receptor antagonist UPR1056 was dosed in plasma samples from rats individually administered with a single i.p. dose of 1.25 mg/kg by means of a newly validated HPLC‐MS method. UPR1056 was extracted from rat plasma by protein precipitation with acetonitrile and was separated by linear gradient elution, employing water and methanol both additioned with 0.05% trifluoroacetic acid as mobile phases. UPR1056 was detected in MS using an electrospray ion source operating in positive ion mode. Acquisition was performed in single ion monitoring mode at m/z=349.3. The method was validated over the concentration range of 17.43–1743 ng/mL (50–5000 pmol/mL). Within‐ and between‐run precision for the low, mid and high quality controls (QC) levels were 6.75% or less and accuracy ranged from 95.8 to 107.6%. The lower limit of quantification was 17.43 ng/mL. The analysis of the time course of UPR1056 concentrations over the 24‐h period revealed a Cmax of 1147 ng/mL after 2 h from peripheral administration of the non‐imidazole H3‐receptor antagonist, with a prolonged elimination half‐life of over 9 h.