bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of multi-disciplinary teams in decision-making for patients with recurrent malignant disease
Authors: Strong Sean , Blencowe Natalie S , Fox Tom , Reid Colette , Crosby Tom , Ford Hugo ER , Blazeby Jane M 
Published: May 2012

Background: It is mandatory in many countries for decisions for all new patients with cancer to be made within multi-disciplinary teams (MDTs). Whether patients with disease recurrence should also routinely be discussed by the MDT is unknown. Aim: This study investigated the role of an upper gastro intestinal (UGI) MDT in decision-making for patients with disease recurrence. Design: A retrospective review of prospectively kept MDT records (2010 to 2011) was performed identifying patients discussed with recurrence of oesophagogastric cancer. Information was recorded about: i) why an MDT referral was made, ii) who made the referral and iii) the final MDT recommendation. Implementation of the MDT recommendation was also examined. Participants: All patients discussed with recurrence of cancer at a central UGI cancer MDT were included. Results: During the study 54 MDT meetings included discussions regarding 304 new patients and 29 with disease recurrence. Referrals to the MDT for patients with recurrence came from outpatient clinics ( n=19, 65.5%) or following emergency admission ( n=10). Most referrals were made by the surgical team ( n=25, 86.2%). MDT recommendations were best supportive care ( n=11, 37.9%), palliative chemotherapy ( n=9, 31.0%), stent ( n=5, 17.2%), palliative radiotherapy ( n=3, 10.3%) and further surgery ( n=1, 3.4%), with 25 (86.2%) of these implemented. Conclusion: UGI MDTs focus on new referrals and only a small proportion of patients with recurrent disease are re-discussed. Many patients go on to receive further treatments. Whether such patients are optimally managed within the standard MDT is uncertain, however, and warrants further consideration.
MTHFR C677T, A1298C and ACE I/D polymorphisms as risk factors for diabetic nephropathy among type 2 diabetic patients
Authors: El-Baz Rizk , Settin Ahmad , Ismaeel Azza , Khaleel Abd Allah , Abbas Tarek , Tolba Wafaa , Abd Allah Wafaa , Sobh Mohammed Abd El-Kader 
Published: May 2012

Background: Genetic variations have been proposed to play a role in the susceptibility to diabetic nephropathy. Objectives: To check for the association of genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and angiotensin converting enzyme (ACE) genes with the development of diabetic nephropathy among type 2 diabetic patients. Methods: Participants comprised 202 patients with type 2 diabetes, of whom 102 were affected with diabetic nephropathy. Genetic variants corresponding to MTHFR C677T, A1298C and ACE I/D genotypes were determined using the PCR technique coupled with digestion and restriction analysis. Results: Cases with diabetic nephropathy had a significantly higher frequency of the MTHFR 677 TT, 677 CT, ACE DD mutant genotypes compared with diabetic cases without nephropathy. Analysis of the association of studied MTHFR C677T, A1298C and ACE I/D polymorphisms with albuminuria showed that the MTHFR 677 T polymorphism, in the recessive and dominant models, was a risk factor for both micro and macroalbuminuria, while the ACE DD mutant genotype was a risk factor for microalbuminuria and the MTHFR 1298C in the dominant model only was a risk factor for macroalbuminuria. Conclusion: These findings indicate that ACE and MTHFR genetic polymorphisms might be considered as genetic risk factors for diabetic nephropathy among patients with type 2 diabetes.
Resistin involved in endothelial dysfunction among preclinical Tibetan male young adults
Authors: Yang Bo , Li Min , Chen Bin , Li Tian-De 
Published: May 2012

Introduction: Resistin, an adipocyte-derived hormone, was found to be linked to metabolic syndrome and insulin resistance over the past decade. There is growing evidence that resistin plays a potential role in endothelial dysfunction. To the best of our knowledge, few studies have been concerned with the effect of resistin on endothelial function in a Tibetan population. Aims: To investigate the correlation of resistin and endothelial function among preclinical Tibetan male young adults. Materials and methods: All participants recruited were young adults between 30 and 40 years old of male gender in Lhasa city. All subjects were native Tibetan. A total of 90 healthy subjects were accepted after excluding hypertension, diabetes, hyperlipidemia or coronary artery disease. The subjects were divided into three groups according to flow-mediated dilation (FMD): lower FMD (group A), intermediate FMD (group B) and higher FMD (group C). Body mass index, systolic blood pressure (SBP), diastolic blood pressure (DBP) and cigarette smoking were evaluated. Venous blood was sampled for the measurement of lipid profile, fasting blood glucose (FBG), fasting insulin (FINS), endothelin-1 (ET-1) and plasma resistin quantitation. The non-invasive vascular endothelial function was evaluated through the measurement of FMD with B-mode ultrasound. The insulin resistance was estimated as homeostatic model assessment of insulin resistance (HOMA-IR) = FINS(mu/L)*FBG(mmol/L)/22.5. Results: No statistical significance was found between groups in age, smoking, SBP, DBP, fasting insulin, total cholesterol and HOMA-IR ( p>0.05). In the lipid profile, high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterol in group C were better than in groups A and B ( p<0.01). Body mass index, which is an indicator for obesity, was much lower in group C than in group A and B ( p<0.05 and 0.01 respectively). Comparison of plasma resistin concentrations: group A > group B > group C ( p<0.01). Comparison of plasma ET-1 concentrations had a similar result: group A > group B > group C ( p<0.05). The multivariate regression analysis showed that total cholesterol ( p<0.05), LDL cholesterol ( p<0.01), plasma resistin ( p<0.01) and plasma ET-1 ( p<0.01) were correlated with FMD. Conclusions: Resistin is involved in endothelial dysfunction in preclinical male young Tibetan adults.
Safety and efficacy of intracoronary adenosine administration in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention: a meta-analysis of randomized controlled trials
Authors: Singh Mukesh , Shah Tejaskumar , Khosla Kavia , Singh Param , Molnar Janos , Khosla Sandeep , Arora Rohit 
Published: May 2012

Background: Studies evaluating intracoronary administration of adenosine for prevention of microvascular dysfunction and ischemic-reperfusion injury in patients with acute myocardial infarction (AMI) undergoing primary percutaneous coronary intervention (PCI) have yielded mixed results. Therefore, we performed a meta-analysis of these trials to evaluate the safety and efficacy of intracoronary adenosine administration in patients with AMI undergoing primary PCI. Methods: A total of seven prospective randomized controlled trials were analyzed. The endpoints extracted were post-procedure residual stent thrombosis (ST) segment elevation and ST segment resolutions (STRes), difference in peak creatine kinase (CK-MB) concentration, thrombolysis in myocardial infarction (TIMI) grade III flow (TIMI 3 flow), myocardial blush grade (MBG) 3, mean difference in post-PCI ejection fraction (EF), all-cause mortality, cardiovascular mortality, heart failure (HF) and major adverse cardiovascular event (MACE). Safety endpoints analyzed were bradycardia, second-degree atrioventricular block (AVB), ventricular tachycardia (VT), ventricular fibrillation (VF) and recurrence of chest pain (CP). The endpoints were analyzed by standard methods of meta-analysis. Results: Intracoronary adenosine therapy led to significantly more post-PCI STRes [relative risk (RR) 1.39, 95% confidence interval (CI) 1.01–1.90; p = 0.04] and reduction in residual ST segment elevation (RR 0.82, CI 0.69–0.99; p = 0.04) but did not improve TIMI 3 flow (RR 1.09, CI 0.94–1.27; p = 0.25), MBG3 (RR 1.04, CI 0.65–1.69; p = 0.88), peak CK-MB concentration (mean difference −39.43, CI −120.223 to 41.371; p = 0.339) and post-PCI EF (mean difference 1.238, CI −5.802 to 8.277; p = 0.730). There was a trend towards improvement and MACE (RR 0.64, CI 0.40–1.03; p = 0.06), incidence of HF (RR 0.47, CI 0.19–1.12; p = 0.08) and CV mortality (RR 0.15, CI 0.02–1.23; p = 0.08) that did not reach statistical significance but no difference in all-cause mortality (RR 0.77, CI 0.25–2.34; p = 0.64). Safety analysis showed no significant difference in CP events (RR 1.26, CI 0.55–2.86; p = 0.58), bradycardia (RR 2.19, CI 0.24–0.38; p = 0.49), VT (odds ratio 0.61, CI 0.08–4.90; p = 0.64) and VF (RR 0.49, CI 0.13–1.90; p = 0.30), but significantly more second-degree AVB (RR 7.88, CI 4.15–14.9; p < 0.01) in the adenosine group compared with the placebo group. Conclusion: Intracoronary adenosine administration was well tolerated and significantly improved electrocardiographic outcomes with a tendency towards improvement in MACE, HF and CV mortality that could not reach statistical significance.
How Nondrug Allergies Are Listed in an Electronic Database; Operating Room Practice: “Stop Using Multiple Dose Vials”; Etravirine and Ethaverine Mix-Up; Rapaflo and Rapamune Confusion
Authors: Cohen Michael R. , Smetzer Judy L. 
Published: May 2012

These medication errors have occurred in health care facilities at least once. They will happen again—perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors in your newsletters and/or presenting them at your inservice training programs. Your assistance is required to continue this feature. The reports described here were received through the Institute for Safe Medication Practices (ISMP) Medication Errors Reporting Program. Any reports published by ISMP will be anonymous. Comments are also invited; the writers' names will be published if desired. ISMP may be contacted at the address shown below. Errors, close calls, or hazardous conditions may be reported directly to ISMP through the ISMP Web site ( www.ismp.org ), by calling 800-FAIL-SAFE, or via e-mail at ismpinfo@ismp.org . ISMP guarantees the confidentiality and security of the information received and respects reporters' wishes as to the level of detail included in publications.
Bedside Barcode Technology: Impact on Medication Administration Tasks in an Intensive Care Unit
Authors: Dwibedi Nilanjana , Sansgiry Sujit S. , Frost Craig P. , Johnson Michael L. , Dasgupta Anandaroop , Tipton Joyce A. , Jacob Sheeba M. , Shippy Angela A. 
Published: May 2012

Purpose To evaluate the effect of bedside barcode medication administration (BCMA) on specific tasks performed by nurses during medication administration in an intensive care unit (ICU). Methods A prospective observational study was conducted on paper-based medication administration (PBMA) and BCMA in an ICU. A prevalidated time and motion observation instrument was used to measure time spent by nurses on tasks associated with PBMA and BCMA. Frequency of each task performed and mean duration of time dedicated to each task were obtained using descriptive statistics. Analysis of covariance was conducted to assess the difference in time spent with various nursing tasks between 2 periods. Factors considered as covariates were age, gender, body weight, length of stay of the patients in the ICU, number of drugs administered, and number of nurses involved. Results A total of 101 PBMA and 151 BCMA were analyzed. The mean duration of total medication administration time was found to be significantly higher during BCMA(377.8 ± 232.8 s) than during PBMA(313.3 ± 224.3 s). During BCMA, nurses spent more time on the following medication administration tasks: drug preparation(159.4 vs 27.3 s; P < .05), assisting physician(5.2 vs. 0.4 s; P < .05), universal precautions(3.6 vs 0.0 s; P < .05), and conversing with patients(21.6 vs 15.0 s; P < .05). During BCMA, nurses spent less time on the following medication administration tasks: giving medications(24.7 vs 35.0 s; P < .05), documenting medications(11.3 vs 17.3 s; P < .05), and cross-checking drugs with orders(7.4 vs 7.6 s; P =.04). Conclusion During PBMA, nurses spent more time on documenting medications and less time conversing with patients. This changed significantly after implementation of BCMA. BCMA resulted in nurses spending less time on documentation and more time conversing with patients during medication administration process.
Stability of Regular Human Insulin Extemporaneously Prepared in 0.9% Sodium Chloride in a Polyvinyl Chloride Bag
Authors: Greenwood Bonnie C. , Chesnick Megan A. , Szumita Paul M. , Belisle Caryn , Cotugno Michael 
Published: May 2012

Purpose The purpose of this study was to evaluate the extended stability of extemporaneously prepared regular human insulin 100 units in 0.9% sodium chloride at a total volume of 100 mL under refrigeration. Methods Three admixtures of regular human insulin were prepared aseptically under a laminar flow hood at time zero. They were prepared by withdrawing 1 mL of regular human insulin with a concentration of 100 units/mL and adding it to a sufficient quantity of 0.9% sodium chloride for injection in a Polyvinylchloride (PVC) bag to yield a total volume of 100 mL. The 3 admixtures were stored refrigerated(2°C to 8°C [36°F to 46°F]) and three 1 mL samples of each admixture were withdrawn, transferred to a test tube, and frozen(–30°C to −15°C [–22°F to 5°F]) at hours 0, 6, 12, 36, 48, 72, 96, 120, 144, and 168. Insulin concentrations were measured by chemiluminescent immunoassay. The time points were considered stable if the mean concentration of the samples exceeded 90% of the equilibrium concentration at hour 6. Results The equilibrium concentration was 0.57 units/mL. Time points were considered stable if the mean concentration was at least 0.52 units/mL. All time points retained at least 90% of the equilibrium concentration with the exception of hour 120(0.46 ± 0.05 units/mL). At hour 168, the mean concentration was 0.63 ± 0.07 units/mL. Conclusion Regular human insulin 100 units added to 0.9% sodium chloride for injection in a PVC bag to yield a total volume of 100 mL is stable for 168 hours when stored at 2°C to 8°C(36°F to 46°F).
Detection of Microdeletion 22q11.2 in a Fetus by Next-Generation Sequencing of Maternal Plasma
Authors: Jensen Taylor J , Dzakula Zeljko , Deciu Cosmin , van den Boom Dirk , Ehrich Mathias 
Published: May 2012

Abstract

BACKGROUND
Efforts have been undertaken recently to assess the fetal genome through analysis of circulating cell-free (ccf) fetal DNA obtained from maternal plasma. Sequencing analysis of such ccf DNA has been shown to enable accurate prenatal detection of fetal aneuploidies, including trisomies of chromosomes 21, 18, and 13. We sought to extend these analyses to examine subchromosomal copy number variants through the sequencing of ccf DNA. We examined a clinically relevant genomic region, chromosome 22q11.2, the location of a series of well-characterized deletion anomalies that cause 22q11.2 deletion syndrome.

METHODS
We sequenced ccf DNA isolated from maternal plasma samples obtained from 2 patients with confirmed 22q11.2 deletion syndrome and from 14 women at low risk for fetal chromosomal abnormalities. The latter samples were used as controls, and the mean genomic coverage was 3.83-fold. Data were aligned to the human genome, repetitive regions were removed, the remaining data were normalized for GC content, and z scores were calculated for the affected region.

RESULTS
The median fetal DNA contribution for all samples was 18%, with the affected samples containing 17%–18% fetal DNA. Using a technique similar to that used for sequencing-based fetal aneuploidy detection from maternal plasma, we detected a statistically significant loss of representation of a portion of chromosome 22q11.2 in both of the affected fetal samples. No such loss was detected in any of the control samples.

CONCLUSIONS
Noninvasive prenatal diagnosis of subchromosomal fetal genomic anomalies is feasible with next-generation sequencing.
The Mediating Effect of Psychological Capital on the Budget Participation-Job Performance Relationship
Authors: Venkatesh Roopa , Blaskovich Jennifer 
Published: May 2012

ABSTRACT
This study draws from the literature in positive psychology and organizational behavior to examine the role of an individual's psychological capital (PsyCap) on the budget participation-job performance relationship. PsyCap is an emerging construct that represents an individual's positive state of psychological development, and is characterized by the individual's hope, efficacy, optimism, and resiliency. We surveyed 109 employees working in organizations across the United States who are actively involved in the budget-setting process or have budgetary responsibilities. The results of a mediation analysis show that budget participation is significantly and positively associated with employees' levels of PsyCap, which is in turn significantly and positively associated with higher levels of job performance. Supplemental analysis using a structural equation modeling technique also supported the hypotheses of this study.
Dynamic effect algebras
Authors: Chajda Ivan , Kolařík Miroslav 
Published: May 2012

Abstract
We introduce the so-called tense operators in lattice effect algebras. Tense operators express the quantifiers “it is always going to be the case that” and “it has always been the case that” and hence enable us to express the dimension of time in the logic of quantum mechanics. We present an axiomatization of these tense operators and prove that every lattice effect algebra whose underlying lattice is complete can be equipped with tense operators. Such an effect algebra is called dynamic since it reflects changes of quantum events from past to future.
Remarks on annihilators preserving congruence relations
Authors: Celani Sergio 
Published: May 2012

Abstract
In this note we shall give some results on annihilators preserving congruence relations, or AP-congruences, in bounded distributive lattices. We shall give some new characterizations, and a topological interpretation of the notion of annihilator preserving congruences introduced in [JANOWITZ, M. F.: Annihilator preserving congruence relations of lattices, Algebra Universalis 5 (1975), 391–394]. As an application of these results, we shall prove that the quotient of a quasicomplemented lattice by means of a AP-congruence is a quasicomplemented lattice. Similarly, we will prove that the quotient of a normal latttice by means of a AP-congruence is also a normal lattice.
Torsion classes of generalized Boolean algebras
Authors: Jakubík Ján 
Published: May 2012

Abstract
Torsion classes and radical classes of lattice ordered groups have been investigated in several papers. The notions of torsion class and of radical class of generalized Boolean algebras are defined analogously. We denote by T
g and R
g the collections of all torsion classes or of all radical classes of generalized Boolean algebras, respectively. Both T
g and R
g are partially ordered by the class-theoretical inclusion. We deal with the relation between these partially ordered collection; as a consequence, we obtain that T
g is a Brouwerian lattice. W. C. Holland proved that each variety of lattice ordered groups is a torsion class. We show that an analogous result is valid for generalized Boolean algebras.
Ordered semigroups whose elements are separated by prime ideals
Authors: Kehayopulu Niovi 
Published: May 2012

Abstract
In this paper we add one more characterization of intra-regular ordered semigroups in the existing bibliography by proving that the ordered semigroups whose elements are separated by prime ideals are actually the intra-regular ordered semigroups, a result which generalizes the corresponding result of semigroups (without order).
On α-complete retracts of specker lattice ordered groups
Authors: Jakubík Ján 
Published: May 2012

Abstract
Let α be a cardinal. The notion of α-complete retract of a Boolean algebra has been studied by Dwinger. Specker lattice ordered groups were investigated by Conrad and Darnel. Assume that G is a Specker lattice ordered group generated by a Boolean algebra B(G). The notion of α-complete retract of G can be defined analogously as in the case of Boolean algebras. In the present paper we deal with the relations between α-complete retracts of G and α-complete retracts of B(G).
On generalized (θ, φ)-derivations in semiprime rings with involution
Authors: Ashraf Mohammad , Nadeem-ur-Rehman  , Ali Shakir , Mozumder Muzibur 
Published: May 2012

Abstract
The main purpose of this paper is to prove the following result: Let R be a 2-torsion free semiprime *-ring. Suppose that θ, φ are endomorphisms of R such that θ is onto. If there exists an additive mapping F: R → R associated with a (θ, φ)-derivation d of R such that F(xx*) = F(x)θ(x*) + φ(x)d(x*) holds for all x ∈ R, then F is a generalized (θ, φ)-derivation. Further, some more related results are obtained.
Finite groups with weakly S-quasinormal subgroups
Authors: Zhao Zhixin 
Published: May 2012

Abstract
We introduce a new subgroup embedding property in a finite group called weakly S-quasinormality. We say a subgroup H of a finite group G is weakly S-quasinormal in G if there exists a normal subgroup K such that HK ⊴ G and H ∩ K is S-quasinormally embedded in G. We use the new concept to investigate the properties of some finite groups. Some previously known results are generalized.
Bochner algebras and their compact multipliers
Authors: Abtahi Fatemeh , Isfahani Rasoul , Rejali Ali 
Published: May 2012

Abstract
Let $\mathfrak{A}$ be a normed algebra with identity, Ω be a locally compact Hausdorf space and λ be a positive Radon measure on Ω with supp(λ) = Ω. In this paper, we establish a necessary and sufficient condition for L
1(Ω, $\mathfrak{A}$) to be an algebra with pointwise multiplication. Under this condition, we then characterize compact and weakly compact left multipliers on L
1(Ω, $\mathfrak{A}$).
Some inclusion relationships and integral-preserving properties of certain subclasses of p-valent meromorphic functions associated with a family of linear operator
Authors: Aouf M. , Shamandy A. , Mostafa A. , El-Emam F. 
Published: May 2012

Abstract
By making use of a general linear operator we introduce several new subclasses of multvalent meromorphic functions and investigate various inclusion relationships. Several interesting integral-preversing properties are also discussed.
Convergence field of Abel’s summation method
Authors: Letavaj Peter 
Published: May 2012

Abstract
Let F(A) denote the set of all bounded sequences summable by Abel’s method. It is known, that F(A) is a linear subspace of the linear metric space (S, ρ) of all bounded sequences endowed with the sup metric. It is shown in [KOSTYRKO, P.: Convergence fields of regular matrix transformations 2, Tatra Mt. Math. Publ. 40 (2008), 143–147] that the convergence field of a regular matrix transformation is a σ-porous set. We show that F(A) is very porous in S.