bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between incidence and report of medication errors and working conditions
Authors: Joolaee S. , Hajibabaee F. , Peyrovi H. , Haghani H. , Bahrani N. 
Published: January 2011

JOOLAEE S., HAJIBABAEE F., PEYROVI H., HAGHANI H. & BAHRANI N. (2011) The relationship between incidence and report of medication errors and working conditions. International Nursing Review58, 37–44Background:  Medication errors are considered to be a serious threat to patients' safety. Efforts to detect and prevent these errors have increased considerably in recent years.Aim:  To determine the incidence and reporting rate of medication errors as reported by Iranian nurses and their relationship with work conditions in hospitals under the authority of Iran University of Medical Sciences.Methods:  This descriptive‐analytical study was carried out in six hospitals. Through a stratified multiple stage sampling, 300 nurses were selected. A researcher‐constructed, three‐part, self‐report questionnaire was used to collect data regarding the nurses' medication errors, medication error reports and their perceived working conditions during the previous 3 months. The data were processed using descriptive statistics and Kruskal–Wallis one‐way analysis of variance.Findings:  The mean of medication errors that nurses recalled was 19.5, and the mean of error reporting was 1.3 cases during the previous 3 months. The relationship between error incidence and work conditions as perceived by nurses was statistically significant (df = 3, P ≤ 0.0001); however, there was no significant relationship between reporting the occurred error and nurses' perceived work conditions (df = 3, P ≤ 0.255).Conclusion and implications:  The establishment of an efficient reporting system, documentation of errors and removal of obstacles to reporting may result in reduced frequency of medication errors. Considering the relationship between medication error incidence and working conditions, it seems that creating a work condition in which nurses feel more comfortable and decreasing work tensions may pave the way to preventing nursing errors.
Price and earnings momentum in Australian stock returns
Authors: Schneider Paul , Gaunt Clive 
Published: January 2011

AbstractThere is no prior published Australian research on earnings momentum and only one prior unpublished work of limited depth and scope. We provide some of the first Australian evidence on earnings momentum and revisit price momentum with the first Australian evidence of the behaviour of returns beyond 12 months. Price momentum is found to be a feature of this market, but there is some reversal of returns during the second year after portfolio formation, suggesting trend chasing behaviour. Earnings momentum is also present, but with weak continuation into the second year. Price momentum and earnings momentum are shown to provide independent explanatory power over future returns.
Canine Spinal Nephroblastoma: Long‐Term Outcomes Associated with Treatment of 10 Cases (1996–2009)
Authors: Liebel Francois‐Xavier , Rossmeisl John H. , Lanz Otto I. , Robertson John L. 
Published: January 2011

Objective:To report clinical outcome associated with treatment of canine spinal cord nephroblastoma (CSN).Study Design:Case series.Animals:Dogs (n=10) with histopathologically confirmed CSN.Methods:Records of dogs with CSN were reviewed and clinicopathologic, diagnostic imaging, treatment, outcome, and survival data were collected.Results:CSN resulted in clinical signs of chronic, progressive T3–L3 myelopathy in young, large breed dogs, with an overrepresentation of German Shepherd Dogs (n=4). All CSN were located between T9 and L2. Dogs treated with cytoreductive surgery (n=6) or radiotherapy (1) survived longer (median, 374 days; range, 226–560 days) than dogs treated palliatively (3; median, 55 days; range, 38–176 days). Tumors confined to an intradural–extramedullary (ID–EM) location were associated with superior survival (n=6; median, 380 days; range, 176–560 days) than tumors with intramedullary (IM) involvement (n=4; median, 140 days; range, 38–269 days). Treatment resulted in temporary improvement in neurologic function in 9 dogs, including all dogs treated surgically, but local disease progression resulted in death of 8 dogs.Conclusions:Results of this observational study suggest that surgical cytoreduction and radiotherapy are effective at improving survival in dogs with CSN, and that ID–EM tumors may be associated with a more favorable prognosis than IM neoplasms.
Evaluation of the overnight hold of whole blood at room temperature, before component processing: platelets (PLTs) from PLT‐rich plasma
Authors: van der Meer Pieter F. , Cancelas Jose A. , Vassallo Ralph R. , Rugg Neeta , Einarson Mindy , Hess John R. 
Published: January 2011

BACKGROUND: Whole blood (WB) must be refrigerated within 8 hours to optimize Factor VIII : C yield, but chilled platelets (PLTs) are rapidly removed from circulation and cannot be used clinically. It is logistically preferable to hold WB overnight at room temperature for next‐day processing. We compared in vitro quality of PLT‐rich plasma (PRP)‐derived PLT concentrates (PCs) from fresh versus overnight‐held WB.STUDY DESIGN AND METHODS: Four units of WB were pooled and split to prevent donor‐dependent differences. One unit was processed immediately; three others were held at room temperature and processed after 24 to 26 hours. After soft‐spin centrifugation, PRP was separated from the red blood cells. PRP was hard‐spun to make PLT‐poor plasma, and the PLTs were resuspended in approximately 60 mL of plasma and stored for 7 days (n = 8 paired experiments by two blood centers).RESULTS: After overnight hold, the PLT concentration was 1.37 × 109 ± 0.19 × 109/mL versus 1.03 × 109 ± 0.32 × 109/mL for freshly prepared PCs (p < 0.05). pH and glucose were significantly lower and lactate higher for overnight‐held units on Day 1, but by Day 5, the differences had disappeared. Hypotonic shock response was initially better, 73 ± 14% for overnight‐held versus 53 ± 12% for freshly processed (p < 0.001), but this difference also disappeared during storage. Activation marker CD62P was not different.CONCLUSION: In vitro storage conditions produce immediate differences after preparation, which disappear throughout storage. PCs from overnight‐held WB have similar in vitro variables as from freshly processed WB. These findings warrant confirmation in clinical trials, but underscore the possibility of use of these PCs as being equivalent to those obtained from freshly processed WB.
A Combined TCD and MRA Screening for Significant Siphon Portion of Internal Carotid Artery (S‐ICA) Stenosis
Authors: Aoki Junya , Kimura Kazumi , Iguchi Yasuyuki , Shibazaki Kensaku , Kobayashi Kazuto , Sakai Kenichiro , Sakamoto Yuki 
Published: January 2011

ABSTRACTBACKGROUNDWe investigated whether combined transcranial Doppler (TCD) and magnetic resonance angiography (MRA) can diagnose significant stenosis (s‐stenosis) of the siphon portion of the internal carotid artery (S‐ICA) on digital subtraction angiography (DSA).METHODSTCD criteria cut‐off peak systolic blood‐flow velocity of 75 cm/s or mean blood‐flow velocity of 50 cm/s, with both values more than 30% higher than in the contralateral S‐ICA. MRA criterion was defined as a ≥50% signal reduction of the column width. Combined TCD and MRA criteria were fulfillment of both TCD and MRA criteria.RESULTSAmong 295 vessels, seven (2%) had s‐stenosis on DSA. Using TCD criteria, 16 vessels (5%) were identified to have s‐stenosis, of which six (38%) had s‐stenosis on DSA (sensitivity, specificity, positive predictive value [PPV], and negative predictive value [NPV] were .86, .97, .38, and .99). Using MRA criteria, 17 (6%) vessels were s‐stenosis, of which seven (41%) had s‐stenosis on DSA. Sensitivity, specificity, and NPV were 1.00, .97, and 1.00; however, PPV was low (.41). Combined TCD and MRA criteria identified six (2%) vessels as having s‐stenosis, all were s‐stenosis on DSA (PPV was 1.00).CONCLUSIONCombined TCD and MRA examinations have similar diagnostic power to DSA. J Neuroimaging 2012;22:172‐176.
Traumatic Middle Cerebral Artery Aneurysm Secondary to a Gunshot Wound
Authors: Santos Gonçalo , Lima Tiago , Pereira Sara , Machado Egídio 
Published: January 2011

ABSTRACTTraumatic intracranial aneurysms are rare lesions, accounting for less than 1% of all intracranial aneurysms. Formation of these lesions after a penetrating missile wound is very unusual, and diagnosis can be difficult due to the presence of associated lesions. In this article, we report a case of a woman who developed a middle cerebral artery aneurysm after a gunshot wound, and discuss potential pitfalls found during diagnostic work‐up.
Imaging Inflammation in a Patient with Epilepsy Due to Focal Cortical Dysplasia
Authors: Butler Tracy , Ichise Masanori , Teich Andrew F. , Gerard Elizabeth , Osborne Joseph , French Jacqueline , Devinsky Orrin , Kuzniecky Ruben , Gilliam Frank , Pervez Fahad , Provenzano Frank , Goldsmith Stanley , Vallabhajosula Shankar , Stern Emily , Silbersweig David 
Published: January 2011

ABSTRACTBACKGROUND AND PURPOSEEvidence from animal models and examination of human epilepsy surgery specimens indicates that inflammation plays an important role in epilepsy. Positron emission tomography (PET) using [C11]PK11195, a marker of activated microglia, provides a means to visualize neuroinflammation in vivo in humans. We hypothesize that in patients with active epilepsy, [C11]PK11195 PET (PK‐PET) may be able to identify areas of focally increased inflammation corresponding to the seizure onset zone.METHODSA young woman with intractable epilepsy underwent PK‐PET as part of an approved research study. PK‐PET results were compared with results from other clinical studies.RESULTSPK‐PET revealed an area of focally increased radiotracer uptake in the right frontal lobe corresponding to this patient's seizure focus as identified by ictal and interictal 18F‐fluorodeoxyglucose (FDG)‐PET and EEG. Routine brain magnetic resonance imaging (MRI) was initially considered normal, though high‐resolution studies showed possible subtle dysplasia of the right frontal lobe. The patient underwent a right frontal lobe resection, and pathological evaluation showed focal cortical dysplasia with activated microglia.CONCLUSIONSPK‐PET can identify neuroinflammation associated with subtle focal cortical dysplasia, and may therefore have a clinical role in guiding epilepsy surgery for patients with difficult‐to‐localize seizure foci.
Comparison Between Lysine Vasopressin and a Long‐Acting Analogue (Nα‐Triglycyl‐Lysine Vasopressin) used as Local Hemostatic Agents for Conization
Authors: Rundqvist Eva , Allen David , Larsson Göran 
Published: January 2011

AbstractLysine vasopressin and a long‐acting analogue Nα‐triglycyl‐lysine vasopressin were compared in a prospective randomized double‐blind study including 71 women undergoing cold knife conization of the uterine cervix. Hemodynamic and hemostatic variables were studied. Nα‐triglycyl‐lysine vasopressin had the following advantages over lysine vasopressin: it gave significantly less skin pallor, becoming evident at a later stage during the operation. The diastolic blood pressure was significantly lower, as also was the incidence of postoperative hemorrhages. Factor VIII related antigen was lower. On the other hand reduction in heart rate (values before conization compared with values during conization) was more pronounced when Nα‐triglycyl‐lysine vasopressin was used, but there was no difference in absolute values between the two groups during conization.
Reduced Incidence of Postoperative Endometritis by the use of Laminaria Tents in Connection with First Trimester Abortion
Authors: Bryman I. , Granberg S. , Norström A. 
Published: January 2011

AbstractA Laminaria tent was inserted in the cervical canal of 115 primigravidae prior to vacuum aspiration in the first trimester. A mean dilatation of 9.7 mm was thereby achieved. Only 2 of these patients were treated by antibiotics due to ‘mild’ endometritis, as compared with 10 of 130 control patients due to endometritis and 7 patients due to ‘mild’ endometritis. Three non‐treated control patients had to undergo laparoscopy due to perforation of the uterus during dilatation of the cervical canal. It is concluded that pre‐treatment with the Laminaria tent prior to vacuum aspiration reduces the incidence of per‐ and post‐operative complications.
Umbilical Artery and Uteroplacental Blood Flow Velocity Waveforms in Normal Pregnancy — A Cross‐Sectional Study
Authors: Gudmundsson Sæmundur , Maršál Karel 
Published: January 2011

AbstractUmbilical and arcuate artery blood flow velocity waveforms (FVW) were recorded in 125 normal singleton pregnancies from 20 to 42 weeks of gestation. The FVW were analysed for pulsatility index (PI), peak systolic velocity/minimum diastolic velocity ratio (S/D ratio), rising slope (RS) and descending slope (DS). Both in the umbilical and arcuate arteries, values for all variables declined with advancing gestation, indicating decreasing placental vascular resistance. The umbilical artery PI was unaffected by the fetal heart rate, but the arcuate artery PI was negatively correlated to the maternal heart rate (r = −0.40). The arcuate artery PI decreased by 0.00394 with each beat per minute increase in maternal heart rate. Normal limits (mean ± 2 SD) were established for umbilical artery PI corrected for gestational age, and arcuate artery Pi corrected for gestational age and maternal heart rate.
Dehydroepi and Rosterone Sulfate in Saliva
Authors: Lagrelius Anders , Fridström Margareta , Möllerström Gunnar , Carlström Kjell 
Published: January 2011

AbstractConcentrations of dehydroepiandrosterone sulfate (DHAS) in saliva and serum were determined in 11 healthy men aged 23–40yrs. 55 healthy, non‐medicated women aged 20–81 yrs and 13 healthy women aged 20–30 yrs, all taking combined oral contraceptives (OC). Serum DHAS was higher in men than in women of corresponding age and was negatively correlated to age in OC‐free women. These sex‐ and age‐related differences were not found for salivary DHAS. Salivary and serum DHAS values were poorly correlated and the ratios between salivary and serum DHAS were variable, with a tendency to higher values in older subjects. Low salivabrum DHAS ratios were found in OC users. The lack of a uniform, unequivocal relation between DHAS concentrations in saliva and serum renders salivary DHAS assays unsuitable for clinical purposes.
An Unusually Aggressive Verrucose Carcinoma of the Uterine Cervix
Authors: Goldberger Shmuel B. , Rosen Doron J.D. , Fejgin Moshe D. , Marcov Shlomo , Cordoba Mario , Ben‐Aderet Noah 
Published: January 2011

AbstractAn unusual case of Verrucose Carcinoma of the uterine cervix is described. The tumor characteristics, as well as its aggressively malignant potential nature are presented. The unique response to irradiation therapy is discussed, hence the great difficulty in treating the tumor and the importance of early diagnosis to achieve a good prognosis. The literature regarding this unique tumor is reviewed.
Pregnancy in a 50‐Year‐Old
Authors: Helm Peter , øvlisen Bjarni 
Published: January 2011

AbstractA 50‐year‐old women was admitted on suspicion of abdominal tumor. Clinical examination and ultrasonography revealed a living fetus of 24.2 weeks’ gestational age. Amniocentesis revealed trisomy 18 (Edwards’ syndrome). At 34 weeks the fetus died spontaneously, and by cesarean section a stillborn boy of 770 g was delivered. The risk of pregnancy in women after the age of 45 is emphasized.
Adenocarcinoma of Bartholin's Gland Associated with Extramammary Paget's Disease of the Vulva
Authors: Hastrup Nina , Andersen Erik Søgaard 
Published: January 2011

AbstractA case of adenocarcinoma of Bartholin's gland in association with Paget's disease of the vulva, in a 61‐year‐old woman is presented. Only 3 cases of this combination have previously been presented. Carcinoma of Bartholin's gland is a diagnostic problem in most cases, as in the present. Radical vulvectomy and bilateral inguinal‐femoral lymph node dissection is the recommended mode of treatment.
Awareness,knowledge and practice of evidence‐based dentistry amongst dentists in Kuwait
Authors: Haron I. M. , Sabti M. Y. , Omar R. 
Published: January 2011

AbstractThis study assessed the awareness, knowledge and practice of evidence‐based dentistry (EBD) amongst dentists working in the public sector in Kuwait. Of the 150 randomly selected dentists from all five health districts in Kuwait who had originally been approached, 120 participated by completing a pre‐tested, self‐administered questionnaire (80% response rate). Whereas 60.9% of the group stated that they practice EBD most of the time, fewer (40.8%) had a reasonable understanding of EBD based upon tested knowledge scores of EBD‐related topics. Clinical decisions appeared to be mostly based on the clinician’s own judgment (73.3%) rather than on evidence‐based sources such as PubMed (28.3%) or the Cochrane Library (6.7%). A number of within‐group differences were noted, with women (P < 0.05), those working in a particular district (P < 0.05), those with <10 years’ experience (P = 0.05), those whose first dental qualification had been obtained in Kuwait (P < 0.05), and those who had had any EBD training (P < 0.05) showing greater knowledge of EBD. Training in EBD was felt necessary by a majority of the group, and this may be facilitated if dental centres have access to evidence‐based sources to remove some of the possible barriers to implementation of EBD.
Implementing an evidence‐based metabolic syndrome prevention and treatment program utilizing group visits
Authors: Greer Deborah M. , Hill Dawn C. 
Published: January 2011

Abstract Purpose: To develop and implement a pilot program designed as a shared medical group visit targeting metabolic syndrome prevention in two ethnically diverse patient populations. Data sources: The Cooperative Health Care Clinics (CHCC) module was utilized for group sessions to focus on interactive discussions following the L.E.A.R.N. format in order to encourage healthy lifestyle changes. Participants completed a pre‐ and postknowledge base test that encompassed information on healthy lifestyle changes in addition to disease processes associated with metabolic syndrome. Each didactic session was evaluated using mean ± standard deviation for the knowledge tests. Analysis of variance was used in determining body mass index (BMI) and weight measured at weeks 1, 5, and 10. Participants completed a 5‐point Likert scale satisfaction survey on week 10. Independent means t‐test compared clinic results along with the Satterthwaite approximate t‐test because of unequal sample sizes to evaluate differences in means. Conclusions: There were no significant statistical differences in mean weight or BMI on weeks 1 and 5. However, on week 10, there was a statistically significant difference for waist circumference in both clinics (p= .0466). Knowledge base improved in both clinics with a premean (0 score = 87 ± 18) and postmean (0 score = 93 ± 14). Both sites received high scores for patient satisfaction. Implications for practice: The shared medical group visits program implemented in both clinic sites demonstrated that this is an effective model in which to provide intensive patient education, foster peer support, and facilitate health‐related behavioral changes. Peer support, self‐management, and continuity appear to be important factors in behavior change and improved knowledge.
The Effect of Transdermal Glyceryl Trinitrate on 24 h Ambulatory Blood Pressure in Acute/Subacute Stroke
Authors: Geeganage Chamila M. , Bath Andrew J. G. , Bath Philip M. W. 
Published: January 2011

Background High blood pressure is a common complication in acute stroke and is associated with a poor outcome. Aims This study assesses the effects of transdermal glyceryl trinitrate on 24 h ambulatory blood pressure in patients with recent stroke. Methods One hundred and seven patients with acute ischaemic or haemorrhagic stroke were included. The patients had been enrolled in one of two trials of transdermal glyceryl trinitrate (5 mg daily) or placebo/control, and underwent 24 h ambulatory blood pressure monitoring (56 glyceryl trinitrate, 51 control). Ambulatory blood pressure data were analysed using area under the curve for the entire 24 h, and day and night periods. Nocturnal dipping was defined as a decline in systolic blood pressure >10%. Comparisons of blood pressure between groups were performed by analysis of covariance (ANCOVA) with adjustments for trial and baseline measure. Results In comparison with control, glyceryl trinitrate significantly lowered 24 h blood pressure (systolic blood pressure/ diastolic blood pressure 9·4/4·8 mmHg, P < 0·001/0·001, n = 104), daytime blood pressure (8·7/4·2, P < 0·001/ < 0·001, n = 103) and night-time blood pressure (6·9/1·7, P = 0·008/0·458, n = 86). Only 86 patients (glyceryl trinitrate 45, placebo/control 41) had sufficient night blood pressure measurements to assign dipping status; 28 were dippers (12 glyceryl trinitrate, 16 control) and 58 were nondippers (33 glyceryl trinitrate, 25 control); glyceryl trinitrate significantly lowered systolic but not diastolic blood pressure in both dippers and nondippers. Treatment with glyceryl trinitrate increased the daytime heart rate (4·8 beats/min) but not the night-time heart rate. Patients whose blood pressure did not dip at night had a worse functional outcome at three-months. Conclusions Transdermal glyceryl trinitrate (5 mg) significantly lowered 24 h blood pressure by 9/5 mmHg (equivalent to a 6% reduction) in both dipping and nondipping patients with acute/subacute stroke. This reduction in blood pressure is clinically relevant and is unlikely to be excessive.
The assessment of aspirin resistance by using light transmission and multiple electrode aggregometry
Authors: ULEHLOVA J. , SLAVIK L. , KRCOVA V. , HUTYRA M. , GALUSZKA J. , INDRAK K. 
Published: January 2011

SummaryIntroduction:  The issues related to aspirin [acetylsalicylic acid (ASA)] resistance are still under debate. Depending on the method of assessment and studied patients, the prevalence of ASA resistance is rather heterogeneous, ranging from 5% to 45%. The method most commonly used for assessing platelet function is their aggregation. ASA irreversibly inhibits cyclooxygenase‐1 (COX‐1) by acetylation.Methods:  This study aimed to compare light transmission aggregometry (LTA) and multiple electrode aggregometry (MEA) for the measurement of ASA resistance, using arachidonic acid as an inducer of the reaction.Results:  The study comprised 101 patients with stable ischemic heart disease taking a daily dose of 100 mg of ASA. The rates of ASA resistance were 22.22% and 21.21% as detected by LTA and MEA, respectively. The two methods were statistically compared using Spearman’s nonparametric correlation analysis, with a positive significant correlation (P = 0.01) and medium positive dependence between the methods (r = 0.0539).Conclusion:  If ASA resistance is detected by laboratory tests, replacement of ASA or its combination with other antiplatelet drugs as well as increased dosage may be considered.