bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Exploiting the CNC Side Chain in Heterocyclic Rearrangements: Synthesis of 4(5)‐Acylamino‐imidazoles.
Authors: Palumbo Piccionello Antonio , Buscemi Silvestre , Vivona Nicolo , Pace Andrea 
Published: November 2010

AbstractImines (V) are prepared via a novel non‐reductive amination.
ChemInform Abstract: C—H Bonds as Ubiquitous Functionality: A General Approach to Complex Arylated Imidazoles via Regioselective Sequential Arylation of All Three C—H Bonds and Regioselective N‐Alkylation Enabled by SEM‐Group Transposition.
Authors: Joo Jung Min , Toure B. Barry , Sames Dalibor 
Published: November 2010

AbstractSelective formation of 2‐, 4‐, and 5‐monoarylated, 2,5‐, 2,4‐, and 4,5‐diarylated as well as 2,4,5‐triarylated imidazoles is possible.
ChemInform Abstract: 4‐Bis(methylthio)methylene‐2‐phenyloxazol‐5‐one: Versatile Template for Synthesis of 2‐Phenyl‐4,5‐functionalized Oxazoles.
Authors: Misra Nimesh C. , Ila H. 
Published: November 2010

AbstractA new and simple method affords a number of 2‐phenyl‐4,5‐functionalized oxazoles.
ChemInform Abstract: Concise Asymmetric Synthesis of Fully Substituted Isoxazoline‐N‐oxide Through Lewis Base Catalyzed Nitroalkene Activation.
Authors: Zhong Cheng , Gautam Lekh Nath S. , Petersen Jeffrey L. , Akhmedov Novruz G. , Shi Xiaodong 
Published: November 2010

AbstractThe synthesis of optically active isoxazoline N‐oxides is based on the pyrrolidine‐catalyzed reaction of optically active ketone ylide (I) with a nitroalkene and an aldehyde.
ChemInform Abstract: Palladium‐Catalyzed Direct Oxidative Alkenylation of Azoles.
Authors: Miyasaka Mitsuru , Hirano Koji , Satoh Tetsuya , Miura Masahiro 
Published: November 2010

AbstractIn the presence of AgOAc and Pd(OAc)2 thiazoles and oxazoles smoothly react with activated terminal alkynes to afford alkenylated azoles.
ChemInform Abstract: Microwave‐Assisted Synthesis of 1,3,4‐Oxadiazoles Carrying Benzimidazole Moiety and Their Antimicrobial Properties.
Authors: Gowda Janardhana , Khadar A. M. A. , Kalluraya Balakrishna , Kumari Nalilu Suchetha 
Published: November 2010

AbstractThe benzyl‐substituted products (VIII) and their analogues (IX) exhibit antifungal activity.
ChemInform Abstract: Green Synthesis of 5‐Substituted‐1,3,4‐thiadiazole‐2‐thiols as New Potent Nitrification Inhibitors.
Authors: Saha Ajoy , Kumar Rajesh , Kumar Rajendra , Devakumar C. 
Published: November 2010

AbstractA new one‐pot method is used for the synthesis of acid hydrazides which are further processed in a similar manner to that used in the conventional protocol.
ChemInform Abstract: Gold‐Catalyzed Diastereoselective Cascade Allylation/Enyne Cycloisomerization to Construct Densely Functionalized Oxygen Heterocycles.
Authors: Chen Zili , Zhang Yu‐Xin , Wang Ya‐Hui , Zhu Li‐Li , Liu Heng , Li Xiao‐Xiao , Guo Lin 
Published: November 2010

AbstractInternal propargylic alcohols provide bicyclic derivatives which are generally formed as a single diastereomer.
ChemInform Abstract: One‐Pot Multicomponent Synthesis and Antimicrobial Evaluation of 2′‐(Indol‐3‐yl)‐2‐oxospiro(indoline‐3,4′‐pyran) Derivatives.
Authors: Nandakumar A. , Thirumurugan Prakasam , Perumal Paramasivan T. , Vembu P. , Ponnuswamy M. N. , Ramesh P. 
Published: November 2010

AbstractA simple and efficient method for the one‐pot three component synthesis of new spirooxindoles (IV) and (VI) is developed.
ChemInform Abstract: One‐Pot Synthesis of Polyfunctionalized 4H‐Chromenes and Dihydrocoumarins Based on Copper(II) Bromide‐Catalyzed C—C Coupling of Benzylic Alcohols with Ketene Dithioacetals.
Authors: Liang Deqiang , Wang Mang , Bekturhun Bahargul , Xiong Binbin , Liu Qun 
Published: November 2010

AbstractTitle reaction of benzylic alcohols (II) and (VI) with ketene dithioacetals (I) and (VIII) provides access towards 4H‐chromenes (III), (IX) or dihydrocoumarins (IV), (X), resp., depending on the solvent used and on the reaction time.
ChemInform Abstract: Highly Selective Metalations of Pyridines and Related Heterocycles Using New Frustrated Lewis Pairs or tmp‐Zinc and tmp‐Magnesium Bases with BF3·OEt2.
Authors: Jaric Milica , Haag Benjamin A. , Unsinn Andreas , Karaghiosoff Konstantin , Knochel Paul 
Published: November 2010

AbstractAn unexpected metalation method for various functionalized N‐heterocycles is presented using a premixed solution of BF3·OEt2 and MgCl(TMP)·LiCl in a 1:1 ratio.
ChemInform Abstract: Highly Selective Metalations of Pyridines and Related Heterocycles Using New Frustrated Lewis Pairs or tmp‐Zinc and tmp‐Magnesium Bases with BF3·OEt2.
Authors: Jaric Milica , Haag Benjamin A. , Unsinn Andreas , Karaghiosoff Konstantin , Knochel Paul 
Published: November 2010

AbstractComplementary functionalizations of the heterocycles are achieved by performance of the metalations using different hindered metal amide bases in the presence or absence of BF3·OEt2.
ChemInform Abstract: Synthesis of Polysubstituted Dihydropyridines by Four‐Component Reactions of Aromatic Aldehydes, Malononitrile, Arylamines, and Acetylenedicarboxylate.
Authors: Sun Jing , Xia Er‐Yan , Wu Qun , Yan Chao‐Guo 
Published: November 2010

AbstractThe reaction with cyanoacetates and cyanoacetamide is also possible yielding dihydropyridines like (VII), (X), and (XII).
ChemInform Abstract: Heterocyclization of Functionalized Heterocumulenes with C,N‐, C,O‐, and C,S‐Binucleophiles. Part 11. Synthesis of Dialkyl 2‐Oxo‐3,6‐diaryl‐1,2,3,6‐tetrahydropyrimidine‐4,5‐dicarboxylates by Cyclocondensation of 1‐Chlorobenzyl Isocyanates with Dialkyl Anilinofumarates.
Authors: Vovk M. V. , Kushnir O. V. , Sukach V. A. , Tsymbal I. F. 
Published: November 2010

AbstractSelective saponification of diester (IIId) succeeds under well‐defined conditions; the hydrolysis leads otherwise to a complex mixture of mono‐ and diacids as well as decarboxylation products.
ChemInform Abstract: Montmorillonite K‐10 Catalyzed Cyclization of N‐Ethoxycarbonyl‐N′‐arylguanidines: Access to Pyrimido[4,5‐c]carbazole and Pyrimido[5,4‐b]indole Derivatives.
Authors: Debray Julien , Zeghida Walid , Baldeyrou Brigitte , Mahieu Christine , Lansiaux Amelie , Demeunynck Martine 
Published: November 2010

AbstractTwo new heterocycles (IV) and (VII) are prepared in three steps using a montmorillonite K‐10‐catalyzed intramolecular Friedel—Crafts cyclization as key reaction.
ChemInform Abstract: Practical Synthesis of Quinoxalinones via Palladium‐Catalyzed Intramolecular N‐Arylations.
Authors: Luo Xuehong , Chenard Etienne , Martens Peter , Cheng Yun‐Xing , Tomaszewski Miroslaw J. 
Published: November 2010

AbstractAn efficient and widely applicable method to prepare biologically important quinoxalinone derivatives is reported.
ChemInform Abstract: 1,2‐Oxazines as Building Blocks for Stereoselective Synthesis: Preparation of Oxygen‐Substituted 1,2‐Oxazines, Either by Alcohol Addition or by Epoxidation, and Subsequent Hydrogenation Leading to 1,2‐Amino Alcohols and Pyrrolidines.
Authors: Zimmer Reinhold , Buchholz Monika , Collas Markus , Angermann Joerg , Homann Kai , Reissig Hans‐Ulrich 
Published: November 2010

AbstractDifferent approaches for the synthesis of stereodefined oxygen‐substituted 1,2‐oxazines are presented.
ChemInform Abstract: Synthesis of Small and Large Fused Bicyclic Compounds by Tandem Dienyne Ring‐Closing Metathesis.
Authors: Park Hyeon , Hong You‐Lee , Kim Yongjoo B. , Choi Tae‐Lim 
Published: November 2010

AbstractVarious bicyclic systems are available which contain both small and large ring moieties.
ChemInform Abstract: Neopentylglycolborylation of ortho‐Substituted Aryl Halides Catalyzed by NiCl2‐Based Mixed‐Ligand Systems.
Authors: Moldoveanu Costel , Wilson Daniela A. , Wilson Christopher J. , Leowanawat Pawaret , Resmerita Ana‐Maria , Liu Chi , Rosen Brad M. , Percec Virgil 
Published: November 2010

AbstractIt is found that the systems shown efficiently promote the reactions aryl iodides, bromides, and chlorides.
ChemInform Abstract: Development of Practical Methodologies for the Synthesis of Functionalized Benzoboroxoles.
Authors: Kumar J. Sravan , Bashian Christopher M. , Corsello Michael A. , Jonnalagadda Subash C. , Mereddy Venkatram R. 
Published: November 2010

Abstract2‐Formylboronic acids (I) undergo Baylis—Hillman reaction with activated olefins (II) or Zn‐mediated reaction with bromides (IV) to yield target compounds (III) and homologues of type (V).
ChemInform Abstract: Stereocontrolled Synthesis of 2‐Substituted‐1,3‐Azasilaheterocycles.
Authors: Hernandez Dacil , Nielsen Lone , Lindsay Karl B. , Lopez‐Garcia M. Angeles , Bjerglund Klaus , Skrydstrup Troels 
Published: November 2010

AbstractThe cyclization precursors are prepared starting from chiral α‐silylsulfinamides [cf.
ChemInform Abstract: Construction of the ABC Ring System of Taxanes via Stereoselective One‐Pot Three‐Component Coupling and Intramolecular Alkylation of a Protected Cyanohydrin Ether.
Authors: Serizawa Takayuki , Miyamoto Shigeru , Fuse Shinichiro , Doi Takayuki , Takahashi Takashi 
Published: November 2010

AbstractThe 1,4‐addition of cyclohexenone (II) to the protected cyanohydrin ether (I) and subsequent addition of formaldehyde (III) to the resulting enolate proceed stereoselectively to afford the AC‐ring system (IV).
ChemInform Abstract: A Novel Aryl‐Hydrazide from the Marine Lichen Lichina pygmaea: Isolation, Synthesis of Derivatives, and Cytotoxicity Assays.
Authors: Roullier Catherine , Chollet‐Krugler Marylene , van de Weghe Pierre , Lohezic‐Le Devehat Francoise , Boustie Joel 
Published: November 2010

AbstractA new aryl‐hydrazide (S)‐glutamic acid derivative, pygmeine (Ia), is isolated from the methanolic extract of the title marine lichen.
ChemInform Abstract: Synthesis of Tetrahydroisoquinoline Alkaloids via Anodic Cyanation as the Key Step.
Authors: Louafi Fadila , Hurvois Jean‐Pierre , Chibani Aissa , Roisnel Thierry 
Published: November 2010

AbstractIt allows a new route to title alkaloids such as O,O‐dimethylcoclaurine (Va) and norlaudanosine (Vb).
ChemInform Abstract: Benzylisoquinoline Alkaloids from the Tubers of Corydalis ternata and Their Cytotoxicity.
Authors: Kim Ki Hyun , Lee Il Kyun , Piao Cheng Jie , Choi Sang Un , Lee Jei Hyun , Kim Yeong Shik , Lee Kang Ro 
Published: November 2010

AbstractThe new alkaloids epi‐coryximine (Ib), coryternatine A (Ia) together with both enantiomers of (II), named coryternatine B and C, are isolated along with several known alkaloids from the title plant.
ChemInform Abstract: Anibamine, a Natural Product CCR5 Antagonist, as a Novel Lead for the Development of Antiprostate Cancer Agents.
Authors: Zhang Xueping , Haney Kendra M. , Richardson Amanda C. , Wilson Eden , Gewirtz David A. , Ware Joy L. , Zehner Zendra E. , Zhang Yan 
Published: November 2010

AbstractIt is demonstrated that anibamine (I), a recently isolated alkaloid from Aniba species, produces significant inhibition of prostate cancer cell proliferation at micromolar to submicromolar concentrations as well as suppressing adhesion and invasion of the highly metastatic M12 prostate cancer cell line.
ChemInform Abstract: Efficient Synthesis of 2′‐O‐Cyanoethylated Imidazole C‐Ribonucleoside Phosphoramidite: A Practical Building Block for Probing the Catalytic Mechanism of Ribozymes.
Authors: Araki Lisa , Zhao Zheng‐yun , Lilley David M. J. , Harusawa Shinya 
Published: November 2010

AbstractThe synthesis of the stable imidazole C‐ribonucleoside phosphoramidite (I) is achieved from tribenzyl D‐ribose in ten steps with an overall yield of 41%, providing an improvement of yield compared to the unstable 2‐O‐Tbs phosphoramidite.
ChemInform Abstract: Improved Total Synthesis of Racemic Rutamarin.
Authors: Tong Ling , Xiong Ruisheng , Jiang Hong , Jiang Xiangrui , Sun Hongbin , Jiang Hualiang , Shen Jingshan 
Published: November 2010

AbstractAn improved, convenient and cost‐effective synthesis of title compound (V) is developed that does not require any chromatographic purification steps.
ChemInform Abstract: 7′,8′‐Dihydroobolactone, a Trypanocidal α‐Pyrone from the Rainforest Tree Cryptocarya obovata.
Authors: Davis Rohan A. , Demirkiran Ozlem , Sykes Melissa L. , Avery Vicky M. , Suraweera Lekha , Fechner Gregory A. , Quinn Ronald J. 
Published: November 2010

AbstractIsolation and structure elucidation of the novel secondary metabolite α‐pyrone (I), named 7′,8′‐dihydroobolactone, are reported.
ChemInform Abstract: Preparation and Luminescent Properties of a Novel Red Emitting Phosphor of Ca1‐2xMxIn2O4:xEu3+ (M: Li, Na, K) for White LED Solid‐State Lighting.
Authors: Yan Xiaosong , Li Wanwan , Sun Kang 
Published: November 2010

AbstractThe title phosphors are prepared by solid state reaction of CaCO3, In2O3, Eu2O3, and M2CO3 (M: Li, Na, K) (alumina crucible, 900 °C, 3 h) and characterized by powder XRD and photoluminescence spectroscopy.
ChemInform Abstract: Structural, Electronic, Optical and Vibrational Properties of Nanoscale Carbons and Nanowires: A Colloquial Review
Authors: Cole Milton W. , Crespi Vincent H. , Dresselhaus Mildred S. , Dresselhaus Gene , Fischer John E. , Gutierrez Humberto R. , Kojima K. , Mahan Gerald D. , Rao Apparao M. , Sofo Jorge O. , et al. et al. 
Published: November 2010

AbstractReview: 230 refs.
ChemInform Abstract: Detection and Use of Small J Couplings in Solid State NMR Experiments
Authors: Massiot Dominique , Fayon Franck , Deschamps Michael , Cadars Sylvian , Florian Pierre , Montouillout Valerie , Pellerin Nadia , Hiet Julien , Rakhmatullin Aydar , Bessada Catherine 
Published: November 2010

AbstractReview: 103 refs.
Alterations in Corrected QT Interval Following Liver Transplant in Patients With End‐Stage Liver Disease
Authors: Zurick Andrew O. , Spier Bret J. , Teelin Thomas C. , Lorenze Katelin R. , Alberte Cesar , Zacks Steven , Lindstrom Mary J. , Pfau Patrick R. , Selzman Kimberly 
Published: November 2010

AbstractBackground:Studies have demonstrated that patients with end‐stage liver disease (ESLD) often have a prolonged corrected QT interval (QTc) with variable changes in the QTc post‐transplant. We sought to characterize the prevalence and degree of QTc prolongation in ESLD patients, identify risk factors for QTc prolongation, and assess changes in QTc following transplant.Hypothesis:QTc interval is prolonged in ESLD patients pre‐transplant due to a variety of risk factors and shortens following liver transplantation.Methods:We conducted a retrospective, multicenter study utilizing 2 large liver‐transplant databases. QTc intervals were calculated utilizing Bazett's formula. The cutoff used for prolonged QTc was 440 milliseconds for men and 460 milliseconds for women.Results:There were 269 patients (169 men, 100 women) included in the final analysis. The mean pre‐transplant QTc was prolonged (449.0 ms), whereas the mean post‐transplant QTc shortened and was within normal limits (416.7 ms) (P < 0.0001). QTc shortened after transplant in 87% of patients. QTc normalized in 70% of patients. Age and Model for End‐Stage Liver Disease (MELD) score were not predictive of prolonged QTc at baseline.Conclusions:ESLD patients often have a prolonged QTc, which frequently shortens or normalizes after transplant. Screening for prolonged QTc is warranted if medications known to prolong the QTc interval are used in ESLD patients pre‐transplant. MELD score, age, and sex were not predictive of prolonged QTc at baseline. Copyright © 2010 Wiley Periodicals, Inc.Ms. Lorenze is a student at the University of Wisconsin whose involvement on this project included, but was not limited to, data collection and analysis and manuscript editing. The authors have no funding, financial relationships, or conflicts of interest to disclose.
Long‐Term Results Following Switch From Abciximab to Eptifibatide During Percutaneous Coronary Intervention
Authors: Koutouzis Michael , Lagerqvist Bo , Oldgren Jonas , Åkerblom Axel , Wahlin Magnus , Karlsson Thomas , Albertsson Per , Matejka Göran , Grip Lars 
Published: November 2010

AbstractBackground:The usage of platelet glycoprotein (GP) IIb/IIIa receptor inhibitors improves the outcome during high‐risk percutaneous coronary interventions (PCI). The aim of this study was to evaluate the long‐term effects after a planned switch from abciximab to eptifibatide during PCI.Hypothesis:A switch from the general use of abciximab to eptifibatide as a GP IIb/IIIa in connection with PCI would not have any negative effects on long‐term clinical outcomes.Methods:To reduce costs, a general switch from abciximab to eptifibatide was instituted in 2004 in 2 university hospitals in Sweden. All patients treated 6 months before and 6 months after the switch were followed for 30 months. During the study period, 1038 patients underwent PCI and received a GP IIb/IIIa receptor inhibitor, 481 (46%) before the switch (Group A) and 557 (54%) after the switch (Group B). The 2 groups had similar baseline characteristics. The primary endpoint was the composite of death, myocardial infarction, stroke, or new coronary revascularization (percutaneous or surgical); secondary endpoints were the individual components of this composite. A separate analysis was performed on patients treated for ST‐segment elevation myocardial infarction, non–ST‐segment elevation myocardial infarction/unstable angina, and diabetes, respectively. Data were collected from the Swedish Coronary Angiography and Angioplasty Registry.Results:There were no differences between the groups in the primary endpoint (29.7% in Group A vs 29.3% in Group B; P = 0.48) or in any of the secondary endpoints.Conclusions:A switch from the general usage of abciximab to eptifibatide as a GP IIb/IIIa receptor inhibitor in connection with PCI did not seem to have any negative effects on long‐term clinical outcomes. Copyright © 2008 Wiley Periodicals, Inc.The authors have no funding, financial relationships, or conflicts of interest to disclose.
Hyponatremia in Acute Decompensated Heart Failure: Mechanisms, Prognosis, and Treatment Options
Authors: Jao Geoffrey T. , Chiong Jun R. 
Published: November 2010

AbstractHyponatremia is common and is increasingly recognized as an independent prognostic marker that adversely affects morbidity and mortality in various disease states, including heart failure. In acute decompensated heart failure (ADHF), the degree of hyponatremia often parallels the severity of cardiac dysfunction and is further exacerbated by any reduction in glomerular filtration rate and arginine vasopressin dysregulation. A recent study showed that even modest improvement of hyponatremia may have survival benefits. Although management of hyponatremia in ADHF has traditionally focused on improving cardiac function and fluid restriction, the magnitude of improvement of serum sodium is fairly slow and unpredictable. In this article, we discuss the mechanisms of hyponatremia in ADHF, review its evolving prognostic significance, and evaluate the efficacy of various treatments for hyponatremia, including the recently approved vasopressin receptor antagonists for managing hyponatremia among patients hospitalized for ADHF. Copyright © 2008 Wiley Periodicals, Inc.Dr. Jun Chiong is a member of the Speaker's Bureau of Otsuka Pharmaceutical company. The authors have no additional funding, financial relationships, or conflicts of interest to disclose.
A novel tumor‐node‐metastasis (TNM) staging system of diffuse malignant peritoneal mesothelioma using outcome analysis of a multi‐institutional database*
Authors: Yan Tristan D. , Deraco Marcello , Elias Dominique , Glehen Olivier , Levine Edward A. , Moran Brendan J. , Morris David L. , Chua Terence C. , Piso Pompiliu , Sugarbaker Paul H. ,   Peritoneal Surface Oncology Group
Published: November 2010

AbstractBACKGROUND:Currently, no tumor‐node‐metastasis (TNM) staging system exists for patients with diffuse malignant peritoneal mesothelioma (DMPM). The primary objective was to formulate a clinicopathological staging system through the identification of significant prognostic parameters.METHODS:Eight international institutions with prospectively collected data on patients who underwent cytoreductive surgery and hyperthermic intraperitoneal chemotherapy contributed to the registry. Two hundred ninety‐four patients had complete clinicopathological data and formed the basis of this staging project.RESULTS:Peritoneal cancer index (PCI) was categorized into T1 (PCI 1‐10), T2 (PCI 11‐20), T3 (PCI 21‐30), and T4 (PCI 30‐39). Twenty‐two patients had positive lymph nodes (N1) and 12 patients had extra‐abdominal metastases (M1). The survival for patients with T1 (PCI 1‐10) N0 M0 was significantly superior to the other patients. This group of patients is therefore designated as Stage I. The survival of patients with T2 (PCI 11‐20) and T3 (PCI 21‐30), in absence of N1 or M1 disease, was similar. This group of patients was categorized as Stage II. The survival of patients with T4 (PCI 30‐39), N1, and/or M1 was similarly poor. This group of patients was therefore categorized as Stage III. Three prognostic factors were independently associated with survival in the multivariate analysis: histological subtype, completeness of cytoreduction, and the proposed TNM staging. The 5‐year survival associated with Stage I, II, and III disease was 87%, 53%, and 29%, respectively.CONCLUSIONS:The proposed TNM staging system resulted in significant stratification of survival by stage when applied to the current multi‐institutional registry data. Cancer 2011. © 2010 American Cancer Society.
DNA methylation predicts recurrence from resected stage III proximal colon cancer
Authors: Ahn Joong Bae , Chung Woon Bok , Maeda Osamu , Shin Sang Joon , Kim Hyun Soo , Chung Hyun Chul , Kim Nam Kyu , Issa Jean‐Pierre J. 
Published: November 2010

AbstractBACKGROUND:In colorectal cancer (CRC), DNA methylation anomalies define distinct subgroups termed CpG island methylator phenotype 1 (CIMP1), CIMP2, and CIMP‐negative. The role of this classification in predicting recurrence and disease‐free survival (DFS) in resected stage III CRC was evaluated.METHODS:Sporadic cancers from 161 patients were analyzed. Bisulfite pyrosequencing was used to examine the methylation of 2 global DNA methylation markers (LINE‐1, Alu) and 9 loci (MINT1, MINT2, MINT31, P16, hMLH1, P14, SFRP1, SFRP2, and WNT5A). Mutations in BRAF and KRAS were assayed.RESULTS:Gene hypermethylation clustered in discrete groups of patients, indicating the presence of CIMP. K‐means clustering analysis identified 3 discrete subgroups: CIMP1 (n = 22, 13.7%), associated with proximal location and BRAF mutations; CIMP2 (n = 40, 24.8%), associated with KRAS mutations; and CIMP‐negative (n = 99, 61.5%), associated with distal location. In proximal CRC, CIMP1 was correlated with a higher recurrence rate (53% for CIMP1, 18% for CIMP2, and 26% for CIMP‐negative) and a worse DFS (P = .015). Also in proximal CRC, LINE‐1 methylation was lower in patients whose cancer recurred compared with those whose cancer did not recur (P = .049). In multivariate analysis, CIMP1 and low LINE1 methylation were independent prognostic factors for DFS in proximal CRC (P = .008 for classification by K‐means clustering analysis; P = .040 for LINE‐1 methylation status).CONCLUSIONS:DNA methylation is a useful biomarker of recurrence in resected stage III proximal but not distal CRC. However, as the number of CIMP1 cases was small in distal CRC, further study is required to validate our findings. Cancer 2011. © 2010 American Cancer Society.