bluuebunny/crossref_metadata_2025_split huggingface dataset:
A rare prostatic tumour masquerading clinically as benign prostatic hyperplasia
Authors: Kundargi Vinay S. , Patil Siddanagouda B. , Patil Santosh R. , Shukla Vikas 
Published: June 2024

Prostatic tumours are usually benign. Malignant tumours are usually adenocarcinoma. Rare benign prostate tumours include inflammatory myofibroblastic tumours, which can be found in various body parts and are frequently identified in the lung or abdominal cavity of children and young adults. Inflammatory myofibroblastic tumours of the urinary tract present more often in kidneys. Prostatic inflammatory myofibroblastic tumours are sporadic and rare. Presenting 44 years old male with complaints of gross hematuria for 15 days with recurrent urine retention. Per rectal examination revealed, grade II prostate enlargement was firm in consistency. PSA was mildly raised (4.4 ng/ml). Ultrasound abdomen showed enlarged prostate (volume -40 cc) with irregular margins and heterogeneous echo texture showing increased flow on colour Doppler. Transrectal ultrasound (TRUS) showed a well-defined irregular heterogeneously echoic mass in the transitional zone, but TRUS biopsy showed no malignancy. After TURP, prostate chip examination showed inflammatory myofibroblastic pseudotumour of the prostate. Diﬀerentiation of inflammatory myofibroblastic prostate tumours from malignant tumours through imaging and laboratory tests is diﬃcult. A case of prostatic inflammatory myofibroblastic tumour observed after transurethral resection of the prostate to treat prostate hyperplasia in a 44-year-old man is presented in this report.
Earth health and human health
Authors: Shah Ashutosh , Patel Mayur 
Published: June 2024

Climate change is the greatest threat to global health in the twenty-first century. The World Health Organization (WHO) has cautiously estimated that between 2030 and 2050, climate change could potentially result in an additional 250,000 deaths annually. There are three main ways that climate change impacts health - direct, impact mediated via ecosystem and institution mediated effect. These environmental health problems are putting extra pressure on, and eroding the capacity of, already stretched health care systems. The health sector must comprehend how climate change will affect the services it provides. It could benefit society as a whole and adjust to these climate changes. By investing in healthier buildings, going green, and implementing sustainable operations, the health sector can promote sustainability, greater health equity, and environmental health and meet the health and sustainability-related goals.
Place in therapy of topical amorolfine in the management of onychomycosis and tinea pedis: A survey to understand Indian dermatologists’ perspective
Authors: Jadhwar Sameer , Bag Goutam , Mubashir Syed , Sen Dyotona 
Published: June 2024

Several lines of evidence show that conditions like onychomycosis and tinea pedis often tend to co-exist. While topical antifungal therapy remains the cornerstone for the management of these conditions individually, data is largely scarce on effective treatment options for coexisting cases of onychomycosis and tinea pedis. A total of 218 healthcare professionals (dermatologists and cosmetologists) participated in the online survey on amorolfine 5% nail lacquer and 0.25% cream. Through the survey, the perspectives of these healthcare professionals (dermatologists and cosmetologists) on the management of onychomycosis tinea pedis coexistence, their views on amorolfine as a treatment option, and their patient experiences were recorded. The healthcare professionals (dermatologists and cosmetologists) reported that more than 50% of the patients had recurrent onychomycosis and tinea pedis co-infection. Most patients (72.45%) were prescribed the amorolfine cream given the lower chances of resistance, and due to the synergistic effect it provides with oral antifungals. As for the amorolfine nail lacquer, good patient compliance, lower chances of infection relapse, and better penetration properties compelled healthcare professionals to prescribe the product to most patients (82.18%). Overall, good clinical and patient experiences were noted with amorolfine products.This survey-based study helped us understand the healthcare professionals' take on the management of tinea pedis and onychomycosis co-infection and it revealed that amorolfine cream and nail lacquer were effective in reducing the key symptoms of tinea pedis and onychomycosis, including lesion clearance and discoloration reduction.
Leprosy patterns and challenges for a leprosy free India: A retrospective study
Authors: Achar Arun , Hakim Benazir , Bhunia Somnath , Dutta Oindrila , Sarkar Madhobendra Nath , Mallick Tanvi , Kundu Suman 
Published: June 2024

: Leprosy, chronic infectious disease, caused by Mycobacterium leprae, is a major public health concern in India. Though India has achieved elimination of leprosy, in 2005, as per WHO criteria, there has not been a general acceleration of downward trends in the new case detection rate (NCDR). Thus, acquiring knowledge of its epidemiological variations is essential for early new case detection and disease control. Evaluating current demographic, clinico-epidemiological characteristics of leprosy in a Tertiary Care Hospital, West Bengal, and identifying gaps in rehabilitation counselling and follow up. A retrospective study including 200 patients who have attended Dermatology Outdoor, during Oct, 2022 - Sep 2023.Out of 200 patients, 112 were new cases and 88 were old, Male and female ratio was 3:2. Majority of cases were between (41-60) years, 10% comprising (10-14) years of age. Multibacillary leprosy contributes almost 60%, the most common type being BT Hansen (56%). Lepra reaction and deformity were seen around 30% &15% respectively. Around 4% of the patients, returned back as a case of relapse. Only 5% were being counselled for physical rehabilitation follow up. It has been seen that the number of newly diagnosed patients, leprosy in younger age population, new cases with grade 2 deformity at the time of diagnosis are not in downgrading phase. On top of that, lack of proper counselling and education for rehabilitation, and relapse of the disease were also worrying. This is the time to act on a community based appropriate strategy to break the chain in transmission of leprosy. Last but not the least, to destigmatize the disease is the need of the hour. Thus, united, we can lead towards Leprosy Free India.
Evaluation of D-dimer levels as a marker of chronic refractory urticaria and its correlation with disease severity
Authors: Kaur Tejinder , Margam Nikita , Kaur Sukhraj 
Published: June 2024

: Chronic idiopathic urticaria (CIU) is very well managed by second-generation antihistamines in the majority of the cases but in a certain subset of patients symptoms persist despite their use. A deeper dig into disease pathogenesis will open new treatment options and better patient management. To evaluate D-Dimer as an anti-histaminic resistant chronic urticaria marker and its correlation with disease severity. Forty chronic urticaria patients attending skin OPD were enrolled and divided into 2 groups of 20 patients each according to response to antihistamines. D-dimer levels were done in each patient. Unpaired t-test was used for assessing two groups and Pearsons correlation coefficient was used to find correlation between D-Dimer levels and Urticaria activity score over 7 days (UAS-7).Result- D-dimer levels were significantly higher in group 1(chronic refractory urticaria) as compared to group 2(chronic urticaria) and there is a positive correlation between D-dimer levels and urticaria activity score (UAS7). Newer insights into alternative pathomechanism of chronic urticaria will open up new treatment options for treatment-resistant cases, this will lead to better patient management and improvement in quality of life.
Dermatoscope as a tool to determine the stability of vitiligo
Authors: Sindhuri Gumma , Karim Shefa , Patel Pooja , Nadkarni Nitin , Patil Sharmila , Godse Kiran 
Published: June 2024

Vitiligo is characterised by depigmentation of the skin that occurs without any prior inflammation. In vitiligo, dermatoscopy acts as an auxiliary technique for confirming the diagnosis and also assists in the assessment of disease activity. Present study was done to characterise the deratmoscopic characteristics of vitiligo and to assess the diagnostic utility of dermatoscopy in vitiligo patients. It was cross-sectional observational study conducted over a period of eighteen months from July 2021 to December 2022 in Department of Dermatology, Venereology and Leprosy of tertiary care teaching hospital in Mumbai, India. 50 adults of either sex or age more than 18 years of age attending dermatology outpatient department with a clinical diagnosis of vitiligo constituted the study population. Based on dermatoscopy, 36% of the lesions were unstable and rest 64% were stable. Perilesional and perifollicular hyperpigmentation was significantly associated with stability, while trichome border, satellite lesions and microkoebner phenomenon were found to be significantly associated with unstability of vitiligo. Dermatoscopy is an excellent method for diagnosing vitiligo and assessing disease activity. Since the stability of vitiligo necessitates surgical intervention, dermatoscopic examination may be of great assistance in determining disease activity.
Application of yoga prana vidya (YPV) healing protocols in facial rejuvenation (FR) Treatment without cosmetics, medicines or surgical procedures: An evaluation of the outcomes of YPV FR interventions
Authors: Nanduri Venkata Satyanarayana , Neravetla Jayachander Reddy , Karnani Vishakha , Baliga Mohandas 
Published: June 2024

Skin and Face Regeneration has always attracted human attention. Historically, a variety of methods have been used to stop or lessen the damaging effects of sun exposure or the aging process of the skin. Energy healing distinguishes facial rejuvenation (FR) utilising YPV system protocols as an art and science that is both safer and different from other forms of applications that mostly employ invasive techniques. This study aims to fill the gap in the limited literature on the application of energy healing for FR. Three YPV FR workshops were conducted at different times in different locations, and samples of adult men and women, to examine and document the effects after conducting a single healing session using relevant YPV protocols. Data consisted of photographs taken before and after the intervention, and feedback from the participants. An examination and analysis of the data from 33 participants of the three workshops reveals that noteworthy improvements were seen within 20 minutes of the trial/demonstration period of application of the YPV facial protocols at the demo, and subsequent 30-minute practice in which the participants applied the YPV facial healing protocol on each other in pairs. All participants experienced a glow on their faces at the end of the workshop. Results from this study indicate that after a single session of YPV healing, there are noteworthy improvements in the face and limbs. The YPV system of Energy FR therapy interventions is extremely safe and has no known adverse effects. It has a lot of potential for lengthier interventions with multiple sessions spaced over several days to study the long-term and sustainability effects of YPV FR protocols.
Comprehensive evaluation of enzymatic proteolysis for amlyoid reduction in macular amyloidosis by in vitro, in vivo and in silico methods
Authors: Neve Vrushali , Bhalchim Vrushali , Karwa Pawan Nandkishor , Sabu Ajay , Runje Swapnil 
Published: June 2024

Skin diseases represent a significant burden on global healthcare systems, with protein deposition playing a pivotal role in their pathogenesis, including conditions such as macular amyloidosis. This study aimed to assess the proteolytic activity of the enzyme Papain on deposited protein, offering insights into potential therapeutic strategies. Using a chicken model, the deposition of protein, a key component in skin diseases, was observed predominantly in the ileum. The dose in different concentrations was given to the ileum and observation was taken on alternative days.Dose of complex protein (albumin, beta lactalbumin, alpha-lactalbumin, Immunoglobulin 500mg/ml and 750mg /ml given respectively. Treatment with Papain demonstrated its ability to effectively break down the deposited protein. In invivo method the designated area of the animal's skin where the induction was occur to ensure proper application and observation were Shaved and cleaned. One vehicle control group, one disease group and one test group. The dosing was done by subcutaneous route. Dose of complex protein (albumin, beta lactalbumin, alpha-lactalbumin, Immunoglobulin) 500mg/ml and 750mg /ml were given . For Papaya Extract Dose of 500mg/ml and 750mg /ml were given to animals. In cheken ilium 5days after dosing, length of patch were observed for five days. In wistar rat after 4days the rats seem to develop hyper pigmented patches which were brown in color in disease group. Then the groups of Animal were injected with papain by SC route. Daily interval observations were done. On the 4th day treatment spot becomes reduced and it disappeared slowly. In silico score observed upto -8 which indicate positive binding affinity.These findings underscore the potential of Papain as a promising candidate for the management of protein-related skin disorders, highlighting the importance of enzymatic intervention in mitigating their pathological manifestations.
Contact-tracing outcomes among male syphilis patients at a tertiary care hospital in North Eastern India
Authors: Gogoi Puja , Das Debajit , Gupta Bhaskar 
Published: June 2024

Syphilis is a sexually transmitted infection (STI) with a surge in its prevalence in recent times nationwide. Early detection, timely treatment, and preventive measures are key to managing and preventing the spread of the disease. Contact tracing is a critical public health practice used to control spread of STIs like syphilis.This study compared the results of contact tracing between male syphilis patients who reported having sex with men (MSM), with women alone (MSWO), or with both. A cross-sectional study where 100 male syphilis positive patients patients of age-groups 18-60 years, appearing Department of Dermatology, Venereology & Leprosy, Silchar Medical College with cutaneous manifestations were enrolled in study over 1 year from November 2023 to October 2024. A group of patients came with reactive VDRL & RPR report having history of exposure but no clinical signs were included as latent syphilis.45 (45%) of the male patients in our study were between the ages of 21 and 30. Male patients reported engaging in sex with women only (MSWO) in 68 cases, sex with men (MSM) in 27 cases, and sex with both male and female partners in 5 cases. 189 (57.9%) of the 326 contacts had latent syphilis, 41 (12.5%) had secondary syphilis, and 96 (29.4%) had primary syphilis.: Innovative, fresh methods are required to control syphilisCreating awareness regarding such manifestations and their probable association with sexual practices is also imperative.
Rings on palms! Clinicopathologic features of 10 cases of palmar granuloma annulare
Authors: Tirumalae Rajalakshmi , Ballal Sumedha , Nanaiah Ashitha , JP Pratibha , Jacob Mareen Ann 
Published: June 2024

Palmar granuloma annulare is a rare subtype of granuloma annulare (GA). It can occur along with lesions of granuloma annulare elsewhere or in isolation. However, isolated lesions occurring over the palms possess a diagnostic dilemma because many other cases share similar clinical features.Therefore, histology is essential to arrive at a correct diagnosis. Often, palmar GA lesions may lack the characteristic histologic features of palisading granulomas but have an interstitial pattern of inflammation.Hence it is imperative to be aware with all the morphologic variants of GA in order to make a reliable diagnosis.
Blaschko-linear manifestations in polygenic inflammatory disorders
Authors: J Raghul Kumar , Manipriya Rajan , V.N.S Ahamed Shariff , Vadivelu Sampath 
Published: June 2024

This study delves into the intricate realm of Blaschko-linear dermatoses, initially described by Alfred Blaschko in 1901. The Blaschko lines forms V-shapes on the upper back, S-shapes on the abdomen, inverted U-shapes from the breast area to the upper arm, and perpendicular lines on the extremities. Blaschko’s lines are attributed to the widely accepted theory of embryonic mosaicism in epidermal cells.In this study, the Blaschko-linear manifestations of polygenic inflammatory disorders (BLMMPD) in Indian population is analyzed. Despite various studies on individual linear dermatoses, few Indian studies have explored the correlation between different Blaschko-linear dermatoses and their dermoscopic and histopathological features.The study, conducted from July 2023 to December 2023, includes 28 cases of Blaschko-linear dermatosis of diverse spectrum. Those with dermatosis along blood vessels, lymphatics, nerve trunk and following koebnerization were excluded. The demographic details, clinical manifestations and dermoscopic-histopathological characteristics were documented. In our case series, Lichen striatus and Linear Lichen planus (LP) were noted to be the most common among linear dermatosis, with a notable female predominance (Male: female ratio 0.75:1) and unilateral distribution (85.7%) on the extremities. Other conditions were linear psoriasis, verrucous epidermal nevus, epidermal nevus, hypomelanosis of Ito and Blaschko-linear acquired inflammatory skin eruption (BLAISE). The clinical-histopathological correlation manifested in 64.2% of cases, while dermoscopy exhibited an even higher correlation in 92.8% of cases. While the distribution pattern of linear dermatoses by itself serves as a valuable diagnostic clue, specific diagnosis can be achieved with more accuracy with the help of distinctive dermoscopic features and correlating them further with histopathological features.
THE EFFECT OF SCIENCE LITERACY SKILLS TO CONTEXTUAL THINKING SKILLS ON SCIENCE LITERACY-BASED LEARNING
Authors: Novita Oktaviani  , Ulinnuha Nur Faizah  
Published: June 2024

Along with the development of the 21st century, humans are required to have science literacy and contextual thinking skills. The need for contextual thinking skills and science literacy is one of the challenges in education. This study aims to determine whether science literacy-based learning can improve contextual thinking skills and science literacy skills and to determine the effect of science literacy skills on contextual thinking skills. The method used in this research is quantitative with correlation research design. The sample used was 28 students who participated in filling out the student’s worksheet, multiple choice questions and essay test with a cluster random sampling technique. The research data analysis used non-parametric statistical tests with the help of SPPS 26 for Windows software. The results of this study show that science literacy-based learning improves science literacy with an N-Gain value of 0.1368 and contextual thinking skills with an N-Gain value of 0.6981. Based on the non-parametric statistical test conducted, the sig value is 0.001 or <0.05, and it can be concluded that alternative hypothesis is accepted and science literacy ability affects the ability to think contextually, and there is a correlation coefficient value of 0.601 which means the level of strength of the relationship (correlation) between variables is a strong correlation and is unidirectional. Therefore, to improve literacy and contextual thinking skills, science literacy learning can be used, and high science literacy skills can improve students' contextual thinking skills.
A Grand Challenge: Update on Improved Recovery From Tight/Shale Reservoirs
Authors: Dordzie Gideon , Balhoff Matthew 
Published: June 2024

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This is the third of a series of six articles on SPE’s Grand Challenges in Energy, formulated as the output of a 2023 workshop held by the SPE Research and Development Technical Section in Austin, Texas.
Described in a JPT article last year, each of the challenges will be discussed separately in this series: geothermal energy; net-zero operations; improving recovery from tight/shale resources; carbon capture, storage, and utilization; digital transformation; and education and advocacy.

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The exploration and extraction of hydrocarbons from tight or shale formations have revolutionized the global energy landscape, unlocking vast oil and gas reserves previously considered inaccessible. According to estimates, substantial oil production has been reported for various tight plays in the US in 2024 (Fig. 1).
However, the production process in tight or shale formations is not without its own set of challenges ranging from technological hurdles to environmental concerns. Therefore, understanding the current outlook is essential for stakeholders to navigate the complex terrain.
To address the significant issues outlined by SPE in July 2023 (Halsey et al. 2023), this article intends to explore the complexities of hydrocarbon extraction from tight and shale reservoirs.

Description of Tight/Shale Formations
First, we present a succinct description of tight or shale formations. Tight or shale oil and gas are hydrocarbons found in oil-bearing mudstone, and shale gas is produced from gas shale or associated with tight oil (Boak and Kleinberg 2020). Tight unconventional formations are characterized by the presence of fine-grained sedimentary rocks that are high in organic matter, such as shale, where hydrocarbons are firmly embedded within the rock matrix.

Challenges in Tight or Shale Oil Production
The Existence of Complex Geometry.
Tight and shale formations are known for their complex geological structures, which can make it difficult to predict the distribution and behavior of hydrocarbons within the reservoir. Additionally, shale formations can exhibit significant variability in their thickness, composition, and the occurrence of natural fractures. Hence, it is crucial to understand and navigate the intricate geology of unconventional shale formations to achieve successful shale oil production (Jiang et al. 2016).
Ultralow Reservoir Permeability.
The low permeability of tight formations restricts the flow of hydrocarbons, necessitating techniques such as hydraulic fracturing to create artificial pathways for extraction. However, the effective stimulation of fractures requires the use of cutting-edge drilling and extraction methods, such as multistage hydraulic fracturing (fracking) and horizontal drilling, which in turn require precise engineering and a thorough understanding of reservoir characteristics (Pokalai et al. 2015).