bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental antiulcer drugs. 3. Some unusual transformations of the cyclopenta[c] pyrroles
Authors: Bell Malcolm R. , Oesterlin Rudolf , Geolotte Karl O. , Hlavac Allan G. , Crain Alfred V. R. 
Published: April 2009

AbstractThe cyclopenta[c]pyrrole‐4‐carbonitrile (3) is transformed by hyrlroxylamine in hot alcohol to 4,5,6,6a‐tetrahydro‐l‐imino‐3,5,5,6a‐tetramethyl‐4‐cyclopenta[c]pyrrole methyl ketone oxime (5) in contrast to the cyclopentapyrrole 10 which afforded 1,2‐diacetyl‐3,3,5,5‐tetramethyl‐cyclopentene dioxime (11). The cyclopenta[c]pyrrole‐4‐carboxamide 1 (R = C6H5) yielded the isomeric 2a,3,4,4a,5,6,6a,6b‐octahydro‐2a,4,4,6a‐tetramethyl‐5‐(phenylimino)pentaleno[1,6‐bc]‐pyrrol‐2‐(1H)one (12) in hot dilute hydrochloric acid or hot 99% phosphoric acid. The amide 1 (R = C6H5) was transformed in the solid state by oxygen over a period of several months to a mixture of the isomeric anils, 13 and 14 of 1,7‐diacetyl‐7‐hydroxy‐4,6,6‐trimethyl‐2‐azabicyclo‐[2.2.l.]heptan‐3‐one(16).
1,2‐Benzothiazines VIII. A novel semmler‐wolff type transformation of 2‐methyl‐2H‐1,2‐benzothiazin‐4‐one 1,1‐dioxide oxime
Authors: Zinnes Harold , Comes Roger A. , Shavel John 
Published: April 2009

AbstractRefluxing the oxime (1) of 2‐methyl‐2H‐1,2‐benzothiazin‐4(3H)one 1,1‐dioxide with tri‐fluoroacetic acid or with boron trifluoride in acetic acid gives the corresponding N‐acyl derivative (2 or 3) of 4‐amino‐2‐methyl‐2H‐1,2‐benzothiazin‐3(4H)one 1,1‐dioxide. This transformation appears to be related to the acid catalyzed conversion of α‐tetralone oxime to α‐naphthylamine.
Ring‐opening of heterocyclic organometallics. XII. Rates of the ring‐opening of some 3‐thienyllithium derivatives
Authors: Frejd Torbjörn 
Published: April 2009

AbstractThe ring‐opening rates of some substituted 3‐thienyllithium derivatives have been measured and the activation parameters calculated for the ring‐opening of 2,5‐dimethyl‐3‐thienyllithium. Steric and electronic effects are discussed. J. Chem. Soc., 14, 1085 (1977)
Synthesis of 2‐substituted benzylidene‐6‐b‐nitrothiazolo[3,2‐α]benzimidazol‐3(2H)ones as possible anticonvulsants
Authors: Singh S. P. , Parmar S. S. , Pandey B. R. 
Published: April 2009

AbstractSeveral 2‐substituted benzylidene‐b‐nitrothiazolo[3,2‐α]benzimidazol‐3(2H)ones were prepared by the condensation of 6‐nitrothiazolo[3,2‐α]benzimidazol‐3(2H)one with suitable aryl aldehydes as possible anticonvulsants. Amongst these benzimidazoles, two compounds possessed anticonvulsant activity and provided 60% protection against pentylene‐tetrazol‐induced seizures in mice.J. Heterocyclic Chem., 14, 1093 (1977)
Mass spectral fragmentation pattern of 2,2′‐bipyridyls Part XI. 2,2′‐Iminodipyridine
Authors: Keats N. G. , Summers L. A. 
Published: April 2009

AbstractThe base peak in the mass spectrum of 2,2′‐iminodipyridine is due to the M‐1 ion. There are several minor fragmentation routes from the molecular ion but the principal pathway involves rupture of the central bonds. J. Heterocyclic Chem., 14, 1103 (1977)
A semi‐micro synthesis of selenophene
Authors: Jacobs P. M. , Davis M. A. , Norton H. 
Published: April 2009

AbstractA semi‐micro preparation of selenophene is described which offers a convenient technique for the production of milligram quantities of the heterocycle. Selenophene is synthesized from bis‐(trimethylsilyl)‐1,3‐butadiyne and sodium hydrogen selenide generated in situ from selenium and sodium borohydride in DMF‐water. J. Chem. Soc., 14, 1115 (1977)
Fused indoles. 1. Synthesis of the 1,9‐dihydrothiazino[3,4‐b] indole ring system
Authors: Coppola Gary M. , Hardtmann Goetz E. 
Published: April 2009

AbstractThe title compounds were prepared by treating 2‐chloroindole‐3‐carboxaldehydes and 3‐acetyl‐2‐chloroindole with N‐methylmethanesulfonamide and cyclizing the resulting intermediates with sodium hydride. Spectral data of the products are also discussed. J. Chem. Soc., 14, 1117 (1977)
Synthesis and antiinflammatory activity of the sulfoxides of 4‐[3‐(dimethylamino)propyl] ‐ 3,4‐ dihydro‐ 2‐(1‐hydroxyethyl)‐3‐phenyl‐2H‐1,4‐benzothiazine
Authors: Turk Chester F. , Egli Peter , Krapcho John 
Published: April 2009

AbstractOxidation of 4‐[3‐(dimethylamino)propyl]‐3,4‐dihydro‐2‐(1‐hydroxyethyl)‐3‐phenyl‐2H‐1,4‐benzothiazine, hydrochloride (I) with hydrogen peroxide yielded a mixture of two sulfoxides (II). Since this mixture exhibited antiinflammatory activity, the two components (Isomers A and B) were prepared in purified form by oxidation of I withN‐chlorosuccinimide and hydrogen peroxide, respectively. Isomer A was more potent than Isomer B in the carrageenin‐induced edema test.
Quinazolines and 1,4‐benzodiazepines. LXXVIII Pyrazolo[1,5‐a] [1,4]‐benzodiazepines and Imidazo[1,5‐a] [1,4]benzodiazepinones
Authors: Gilman Norman W. , Holland Betty C. , Fryer R. Ian 
Published: April 2009

AbstractThe syntheses of novel 8‐chloropyrazolo[1,5‐a][1,4]benzodiazepines and of an imidazo‐benzodiazepinone utilizing products from the nucleophilic substitution of fluorine in 2‐fluoro‐5‐nitrobenzophenone (1) by pyrazole‐3,5‐dicarboxylic acid, dimethyl ester (2) and by 2‐methyl‐imidazole‐4,5‐dicarboxylic acid, diethyl ester (30) are described.
Synthetic studies on chemotherapeutics. III. Synthesis of the 6,9‐dihydro‐9‐oxo‐1H‐ and 2H‐pyrazolo[3,4‐f]quinoline‐8‐carboxylic acid derivatives [studies on the syntheses of heterocyclic compounds. Part 718 ]
Authors: Kametani Tetsuji , Kigasawa Kazuo , Hiiragi Mineharu , Wakisaka Kikuo , Kusama Osamu , Sugi Hideo , Kawasaki Kumeo 
Published: April 2009

Abstract1H‐ and 2H‐Pyrazolo[3,4‐f]quinolines were synthesized in order to get an antibacterial compound by two different methods from 6‐nitro‐ and 6‐aminoindazole.
Potentiell tumorhemmende wirkstoffe. IX. 4,5,6‐trialkylierte 2‐methoxy‐ und 2‐(methylthio)pyrimidine
Authors: Kreutzberger Alfred , Tesch Uwe‐Hartmut 
Published: April 2009

AbstractAus der Umsetzung des O‐Methylisoharnstoff‐sulfats (1a) bzw. des S‐Methylisothioharnstoff‐sulfats (1b) mit 3‐Methyl‐2,4‐pentandion (2a) resultieren das 2‐Methoxy‐ (3a) und das 2‐Methyl‐thio‐4,5,6‐trimethylpyrimidin (3b). Die aus den analogen Umsetzungen mit 3‐Äthyl‐2,4‐pen‐tandion (2b) erhältlichen 5‐Äthylpyrimidine (3c und 3d) tendieren in Kontakt mit der Luft unter Abspaltung der 5‐Äthylgruppe zum Übergang in 4,6‐Dimethyl‐2‐methoxypyrimidin (4a) und 4,6‐Dimethyl‐2‐(methylthio)pyrimidin (4b).
The structure of thiophene sesquioxide: Syn, endo‐3a,4,7,7a‐tetrahydro‐4,7‐epithiobenzo[b] thiophene 1,1,8‐trioxide
Authors: Merrill Ronald E. , Sherwood Gary 
Published: April 2009

AbstractThiophene sesquioxide is shown to be syn, endo‐3a,4,7,7a‐tetrahydro‐4,7‐epithiobenzo[b]‐thiophene 1,1,8‐trioxide (I) by 1 H and 13 C nmr evidence. Assignment of the 13 C spectrum was facilitated by a cross‐ring long‐range 13 C‐1 H coupling. The mass spectrum of I is dominated by an unusual break‐down to give benzene radical cation.
1,5‐Dipolar cycloaddition reactions. Semicarbazone bromides, 5‐alkyl (or aryl)amino‐1,3,4‐oxadiazole‐2‐carboxylic acids and their esters
Authors: Werber Giuseppe , Buccheri Francesco , Noto Renato , Gentile Manlio 
Published: April 2009

AbstractThe synthesis of the title compounds from semicarbazones of glyoxylic ester is reported.
Carbon‐13 NMR investigation of the structure of hydroxy‐azoloazines with a bridgehead nitrogen
Authors: Pugmire Ronald J. , Smith James C. , Grant David M. , Stanovnik Branko , Tisler Miha , Polanc Slvenko 
Published: April 2009

AbstractCarbon‐13 nmr data has been obtained on four hydroxy‐azoloazines containing a bridgehead nitrogen atom, on the corresponding methoxide derivatives, and on selected anionic and cationic derivatives. These results have been interpreted in terms of the site of protonation of the parent hydroxy‐compounds. A comparison of the anionic derivatives with those of the parent compounds demonstrate that the neutral parent hydroxy‐species exist predominately in the “hydroxy form” rather than as the ionized species. The chemical shift data also provides information on the conformation of the hydroxy‐ and methoxy‐groups in 8‐hydroxy‐6‐methyl‐s‐triazolo[4,3‐6]‐pyridazine and 8‐rnethoxy‐6‐methyl‐s‐triazolo[4,3‐6]pyridazine.
Réactions induites par les halogénures de pyridinium. XXIV. Sur la synthése de dibenzofurannes à partir de diméthoxy‐2,2′ biphényles
Authors: Bachelet Jean‐Pierre , Demerseman Pierre , Royer René 
Published: April 2009

AbstractCertains dibenzofurannes peuvent ětre obtenus par hétéroeyclisation au moyen du bromure de pyridinium des dihydroxy‐2,2′ biaryles formés par déméthylation au moyen du chlorure de pyridinium des diméthoxy‐2,2′ biaryles. La desalcoylation suivie d'hétérocyclisation en dibenzofurannes des diméthoxy‐2,2′ biaryles par le bromure de pyridinium se complique d'une trans‐methylation indireete. Les dérivés acylés des diméthoxy‐2,2′ biaryles perdent leur groupe acyle lors de leur désalcoylation, suivie ou non d'hétérocyclisation, par les halogénures de pyridinium.
A facile synthesis of some pyrazolo[1,5‐b] ‐1,2,4‐benzothiadiazepin 5(4H)ones 10,10‐dioxides. A new ring system
Authors: Plescia S. , Agozzino P. , Fabra I. 
Published: April 2009

AbstractIsopropyl‐2‐chlorosulfonylbenzoate was treated with some 3(5)aminopyrazoles. A new ring system, pyrazolo[1,5‐b]‐1,2,4‐benzothiadiazepin‐5(4H)one 10,10‐dioxide, was directly obtained.
Carbon‐13 nuclear magnetic resonance spectra of anti‐inflammatory drugs: Phenylbutazone, oxyphenbutazone and indomethacin
Authors: Singh S. P. , Parmar S. S. , Stenberg V. I. , Farnum S. A. 
Published: April 2009

AbstractThe 13C nmr chemical shifts of phenylbutazone, oxyphenbutazone, indomethacin and indole‐3‐acetic acid are reported. The assignments of various carbon resonances are made on the basis of the substitution effects on benzene shifts, multiplicities generated in SFORD spectra, nuclear overhauser enhancement for protonated carbons, and the comparison with analogous compounds.
Synthesis of 5‐methylfuro[3,2‐b]pyridine‐2‐carboxylic acid
Authors: Weis C. D. 
Published: April 2009

AbstractOxidation of 3‐hydroxy‐6‐methyl‐2‐hydroxymethylpyridine with manganese dioxide yielded the corresponding aldehyde, the condensation of which with diethyl bromomalonate furnished hydroxydihydrofuro[3,2‐b]pyridinediearboxylie acid ester. Saponification of the diester with concentrated hydrochloric acid afforded the hydrochloride of 5‐methylfuro[3,2‐b]pyrjdine car‐boxylic acid.
Carbon‐13 nuclear magnetic resonance spectrum of methaqualone
Authors: Singh S. P. , Parmar S. S. , Stenberg V. I. , Akers T. K. 
Published: April 2009

Abstract13C nmr chemical shifts of methaqualone, 2‐methyl‐3‐propyl‐4‐quinazolone, 2‐methyl‐3‐phenyl‐4‐quinazolone and their precursor, acetanthranil, are reported. The signals are assigned on the basis of suhstituent effects on benzene shifts, intensities, multiplicities in SFORD, and comparison with structurally related compounds.
An anomalous acylation of an aminobenzenesulfonamide
Authors: Friary R. 
Published: April 2009

AbstractAcylation of 2‐amino‐4‐chlorobenzenesulfonamide by 2‐acetoxyisobutyryl chloride under acidic conditions unexpectedly gave 6‐chloro‐3‐methyl‐4H‐1,2,4‐benzothiadiazine 1,1‐dioxide and 8‐ehloro‐2,2,3a‐trimethyl‐3a,4‐dihydrooxazolo[2,3‐b] [1,2,4]benzothiadiazin‐1‐one 5,5‐dioxide, the skeletons of which incorporate the carbon atom of the acetoxyl carbonyl group of the acid chloride.
Recherches en série diazépine‐1,4 et triazépine‐1,2,4. IX. Synthéses de nouvelles triazépines‐1,2,4
Authors: Hasnaoui A. , Lavergne J.‐P. , Viallefont Ph. 
Published: April 2009

AbstractLes méthodes de préparation de triazépines‐1,2,4 présentant cinq types de structure, disubstituées dans les positions 3 et 5 par des groupes oxo, thioxo, méthoxy ou méthylthio, sont décrites. Onze triazépines ont ainsi été synthétisées et leurs structures établies à partir de I'ensemble des données spectrales.
The coordination chemistry of simple phospholes: Complexes of nickel(II), palladium(II) and platinum(II)
Authors: Holah David G. , Hughes Alan N. , Hui Benjamin C. , Tse Pui‐Kwan 
Published: April 2009

AbstractThe reactions between four very simply substituted phospholes and the chlorides of Ni(II), Pd(II) and Pt(II) are described. The phospholes 1‐phenylphosphole, 3‐methyl‐1‐phenyl‐phosphole and 3,4dimethyl‐1‐phenylphosphole all readily form bis‐complexes of formula L2MCl2 [L = phosphole ligand and M = Ni(II), Pd(II) or Pt(II)] or tris‐complexes of formula L3MCI2. 1‐n‐Butyl‐3,4‐dimethylphosphole appears to form stable complexes only with Ni(II). Evidence is put forward which indicates that the L2MCl2 complexes exist in a four‐coordinate, square‐planar monomeric/five coordinate equilibrium while the L3MCl2 complexes are primarily the ionic species [L3MCl]+ Cl− in solution. Comparisons are made with the behaviour of other simple phospholes which do not form Ni(II) complexes and the results are discussed briefly in terms of both aromatic and non‐aromatic phosphole models.
Acetylenic ketones. Part V. Reaction of acetylenic ketones with thiourea and some of its derivatives
Authors: Baddar F. G. , Al‐Hajjar F. H. , El‐Rayyes N. R. 
Published: April 2009

AbstractAroylphenylacetylenes (I) reacted with thiourea and S‐benzylisothiourea to give 4,6‐diaryl‐pyrimidine‐2(1H)thiones (IV) and α‐aroyl‐β‐benzylmercaptostyrenes (X), respectively. Methyla‐tion and acetylation of the thiones (IV) gave the corresponding S‐methyl‐ (V) and S‐acetyl‐ (VI) derivatives, respectively. The oxidation of these thiones gave the corresponding disulfide derivatives (VII). Reaction of α‐aroyl‐β‐benzylmercaptostyrenes (X) with hydrazine hydrate and phenylhydrazine gave 3(5)‐aryl‐5(3)‐phenylpyrazoles (XI) and 3‐aryl‐1,5‐diphenylpyrazoles (XIII), respectively. Reaction of aroylphenylacetylenes (1) with N‐allylthiourea gave 1‐allyl‐4,6‐diaryl‐pyrimidine‐2‐thiones (XVI).
Synthesis via pummerer intermediates. II.. Disproportionation reactions of 3‐(methylsulfinyl)chromones and 3‐(methyl‐sulfinyl)quinolinones with hydrochloric acid
Authors: Connor David T. , von Strandtmann Maximillian 
Published: April 2009

AbstractSulfoxides (1 and 10) gave oxidation‐reduction products when treated with 5N hydrochloric acid. 8‐Methoxy‐3‐(methylsulfinyl)‐4H‐benzopyran‐4‐one (1) gave 8‐methoxy‐3‐(methylthio)‐4H‐1‐benisopyran‐4‐one (4) and 8‐methoxy‐3‐(methylsulfonyl)‐4H‐1‐benzopyran‐4‐one (5), whereas 1‐melhyl‐3‐(methylsulfinyl)‐4(1H)quinolinone (10) gave 1‐methyl‐3‐(methylthio)‐4(1H)‐quinolinone (12) and 1‐methyl‐4(1H)‐quinolinone (13).
Studies on mesoionic compounds, II. The solvent effect on the electronic absorption spectra of mesoionic 2,3‐diaryl‐2H‐tetrazolium‐5‐thiolate derivatives
Authors: Kiwan A. M. , Kassim A. Y. 
Published: April 2009

AbstractThe electronic absorption spectra of 2,3‐di(2‐fluorophenyl)‐, 2,3‐di(4‐fluorophenyl)‐, 2,3‐di‐(2‐chlorophenyl)‐, 2,3‐di(2‐methylphenyl)‐, 2,3‐di(4‐methylphenyl)‐ and 2,3‐di(2‐methoxyphenyl)‐2H‐tetrazolium‐5‐thiolates have been measured in pure and mixed solvents. They were found to exhibit three characteristic absorption bands at 480‐380 nm, near 250 and near 210; the longest wavenlength band of which was assigned to an n → π* transition.
Reactions of 2 ‐dichloromethylbenzimidazole with certain primary amines
Authors: Pascal Robert A. , Jungk Steven , Risinger G. E. 
Published: April 2009

AbstractAn investigation of the reactions of 2,2‐dichloromethylbenzimidazole with primary amines has led to the synthesis of 2(N‐t‐butylformimidoyl)benzimidazole, 2‐N‐(2‐phenylethyl)formimdoylbenzimidazole, and 1‐(ethoxyearbonylmethyl)‐2‐(N‐t‐butylformimidoyl)benzimidazole. Under mild alkali conditions, 2,2‐dichloromethylbenzimidazole was rapidly converted into a dimer, namely, 6H,13H‐pyrazino[1,2‐a:4,5‐a']bisbenzimidazole‐6,13‐diol.
Quinazolines and 1,4‐benzodiazepines LXXXII. Reaction of 2‐hydrazino‐benzodiazepines with 1,3‐diearbonyl compounds
Authors: Walser Armin , Zenchoff Gladys 
Published: April 2009

AbstractThe 2‐hydrazinobenzodiazepines 1 were reacted with acelylacelone to form the hydroxy‐pyrazolines 2 which were converted to the triazolobenzodiazcpines 6 and the 2‐pyrazolyl‐benzodiazepine 4. Ring cleavage of the hydrazone 8 obtained from cyclohexane‐1,3‐dione and 1a led similarly to the 1‐(4‐oxopentyl)triazolol)enzodiazepine 12.
Synthesis of 10‐(substituted phenylhydrazonoacetyl)phenothiazines as possible anticonvulsants
Authors: Singh S. P. , Kumar S. , Pandey B. R. , Parmar S. S. 
Published: April 2009

AbstractSome 10‐(substituted phenylhydrazonoacetyl)phenothiazines were synthesized as possible anticonvulsants. These compounds were investigated for their anticonvulsant activity and inhibitory effects on the oxidation of pyruvic acid by rat brain homogenates.
Syntheses of pyrimidine and purine analogs derived from 1,2,6‐thiadiazine 1,1‐dioxide
Authors: Ochoa C. , Stud M. 
Published: April 2009

Abstract5‐Amino‐3‐oxo‐2H, 4H‐1,2,6‐thiadiazine 1,1‐dioxide and the monopotassium salt of 3,5‐dioxo‐2H, 4H,6H‐1,2,6‐thiadiazine 1,1‐dioxide was obtained by condensation of sulfamide and ethyl cyanacetate and diethyl malonate, respectively. 7‐Oxo‐1H,4H,6H‐imidazo[2,3‐c]‐1,2,6‐thia‐diazine 5,5‐dioxide was prepared by a multi‐step reaction sequence from 5‐amino‐3‐oxo‐2H, 4H‐1,2,6‐thiadiazine 1,1‐dioxide.
Synthetic approaches to fused heteroaromatic compounds by the condensation reactions of functional pyrroles
Authors: Uchida Takane 
Published: April 2009

AbstractCondensation reactions ol the “functionalized” pyrroles which were obtained by one pot synthesis of aziridines and acetylenic dipolarophiles were discussed. On treatments of 3,4‐di‐ and 2,3,4‐tribenzoylpyrroles with hydrazine hydrate and phosphorus pentasulfide, the several pyrrolo‐pyridazine derivatives and fused thiophenes, respectively, were prepared. The structure proofs for the products of the reaction of the 2,3,4‐tribenzoylpyrrole (9a) with hydrazine hydrate were based on the 13C FT‐nmr spectrum of the corresponding 13C‐enriched compounds.
Synthesis of 4‐substituted 3‐hydroxy‐and 3‐amino‐6H‐1,2,6‐thiadiazine 1,1‐dioxides
Authors: Goya P. , Stud M. 
Published: April 2009

AbstractReaction of sulfamide with ethoxymethylene derivatives yielded 4‐ethoxycarbonyl‐, 4‐cyano‐, and 4‐nitro‐2H,6H‐1,2,6‐thiadiazine 1,1‐dioxide. In some cases, the corresponding open chain sulfamidomethylene derivatives were isolated. Preparation of 4‐amino‐ and 4‐amino‐5‐methyl‐2H,6H‐1,2,6‐thiadiazin‐3‐one 1,1‐dioxide is also described. Reaction of sulfamide with ethyl 3,3‐ethoxypropionate afforded 3,7‐bis(etlioxycarbonylmethyl)perhydro‐1,5,2,4,6,8‐dithiatetra‐zocine 1,1,5,5‐tetroxide.
Synthesis of 5,6‐dihydro‐2H‐thiopyrans
Authors: Chen C. H. , Reynolds G. A. , Zumbulyadis N. , Van Allan J. A. 
Published: April 2009

AbstractSynthesis of 5,6‐dihydro‐2H‐lhiopyrans by mild dehydromesylation of the corresponding tetrahydro‐4H‐thiopyran‐4‐mesylates using commercial grade Woelrn W‐200 (activity, Super 1) neutral alumina is described.Cis‐ andtrans‐stereoisomers of 2,6‐diphenyl‐5,6‐dihydro‐2H‐thiopyrans were prepared for the first lime without isomerization.
Synthesis of Furo[2,3‐c]isoquinoline Derivatives
Authors: Ito Kazuo , Yakushijin Kenichi , Yoshina Shigetaka , Tanaka Akira , Yamamoto Katsumi 
Published: April 2009

Abstract2‐Methylfuro [2,3‐c] isoquinolin‐5(4H)one (X) and 1‐phenylfuro[2,3‐c] isoquinolin‐5(4H)one (XI) were prepared from thermal cyelization via the Curtius rearrangement of 5‐methyl‐3‐phenyl‐2‐furoyl azide (VI) and 3,4‐diphenyl‐2‐furoyl azide (VII), respectively. Stability against acid, alkylation and conversion of the NHCO group to a C=N double bond of X and XI, which were synthesized, are described. Also, 5‐substituted furo[2,3‐c] isoquinolines (XVIIIa‐c) and (XIXa‐c) were prepared.
A new method for the synthesis of fused 3‐amino‐s‐triazole ring systems
Authors: Lin Yang‐i , Fields T. L. , Lang S. A. 
Published: April 2009

AbstractReaction of 2‐methyl‐2‐thiopseudourea sulfate with 1‐hydrazinophthalazine gave 3‐amino‐s‐triazolo[3,4‐a] phthalazine in good yield. 1‐Amino‐4‐methyl‐s‐triazolo[4,3‐a]quinoxaline and 1‐amino‐s‐triazolo[4,3‐a]quinoxalin‐4(5H)one were similarly perpared.
Steroidal pyrazolines
Authors: Catsoulacos Panayotis , Stassinopoulou C. I. 
Published: April 2009

AbstractReaction of 21‐benzal‐5‐pregnen‐3β‐ol‐20‐one acetate with phenylhydrazine or p‐methoxy‐phenylhydrazine in the presence of hydrochloric acid yielded 3β‐aeetoxy‐1′,5′ ‐diphenyl‐5‐preg‐neno[20,21‐c]pyrazoline. Alkaline hydrolysis of the 3β‐acetoxy group followed by Oppenauer oxidation furnished the 3‐oxo‐1′,5′‐diphenyl‐4‐pregneno[20, 21‐c]pyrazoline. The ir, nrar and mass spectra are described.
Acetylenic ketones. Part VI. Reaction of aroylphenylacetylenes with hydrazine derivatives
Authors: Baddar F. G. , Al‐Hajjar F. H. , El‐Rayyes N. R. 
Published: April 2009

AbstractThe reaction of aroylphenylacetylenes (I) with acyl‐ or aroylhydrazines (II) gave ω‐aroyl‐acetophenone‐N‐acyl or N‐aroylhydrazones (IV). The latter gave upon treatment with methanolic potassium hydroxide and with acetic anhydride in the presence of sodium acetate, the corresponding pyrazoles (V) and the N‐acetylpyrazoles (VII and VIII), respectively. The acetylenic ketones (1) also reacted with methylhydrazine and 1,1‐dimethylhydrazine to give 5‐aryl‐1‐methyl‐3‐phenylpyrazoles (XII), and 1,1‐dimethylhydrazine derivatives (XIII), respectively. When the latter compounds were heated with acetic anhydride, they gave the N‐methylpyrazoles (XII).
Thiocyanation of indoles
Authors: Tamura Yasumitsu , Kwon Sundo , Chun Moon Woo , Ikeda Masazumi 
Published: April 2009

AbstractTreatment of indole, 2‐phenylindole, 2‐methylindole, and ethyl indole‐2‐carboxylate with thiocyanogen in acetic acid at 0° afforded the corresponding 3‐thiocyanatoindoles in quantitative yields, whereas similar treatment of 3‐methyl‐2‐phenylindoles and 2,3‐diphenylindoles gave the corresponding 6‐thiocyanatoindoles in high yields.
Reissert compound studies. XXX. Synthesis and alkylation of some new reissert compounds
Authors: Popp Frank D. , Buhts Robert E. , Chesney Dennis K. 
Published: April 2009

AbstractThe synthesis of several new isoquinoline Reissert compounds is described. Alkylation reactions of the anions of these new Reissert compounds and a rearrangement reaction are reported.
Synthesis and reactivity of indolylmethyl cations
Authors: Berti C. , Greci L. , Marchetti L. 
Published: April 2009

AbstractThe synthesis of diindolylmethyl cations by reaction of aldehydes and indoles is described, and their reaction with Grignard reagents, organo‐lithium compounds and sodium borohydride, giving the corresponding diindolyl methanes, is reported. The analogous phenyl indolylmethyl cations could never be isolated, but their formation was proved indirectly.
SN(ANRORC) mechanism XX. Degenerate ring transformations in reactions of 1,2,4,5‐tetrazines with hydrazine
Authors: Counotte‐Potman A. D. , van der Plas H. C. 
Published: April 2009

AbstractEvidence is presented that the hydrazinolysis of 3‐amino‐ (5) and 3‐bromo‐6‐methyl‐1,2,4,5‐tetrazine (7) into the 3‐hydrazino‐6‐methyl‐1,2,4,5‐tetrazine (6*) with15N‐labelled hydrazine leads to incorporation of15N in the 1,2,4,5‐tetrazine ring. Thus in the hydrazino‐deamination and hydrazino‐debromination a SN(ANRORC) mechanism is operative. Based on quantitative mass spectrometry it was found that 20‐25% of both5and7reacts according to this SN‐(ANRORC) mechanism. The mechanism of these degenerate ring transformations is discussed.