bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on the Practical Path of Integrating the Teaching of Modern and Contemporary Literature and Technology in Colleges and Universities in the Information Age
Authors: Liu Tingting 
Published: April 2024

Abstract
Modern and contemporary literature in colleges and universities is a deeply learned and traditional humanities subject, and the development of Internet technology has a different impact on the form of teaching literature. This paper combines the MOOC platform for information technology with the teaching of modern and contemporary literature and establishes a blended teaching mode for both modern and contemporary literature. Aiming at the problem of personalized recommendation of literature teaching resources in blended teaching, this paper introduces the singular value decomposition to improve the collaborative filtering algorithm in order to meet the students’ efficient learning needs of current and contemporary literature. After the teaching experiment of the blended teaching mode of current and modern literature for the students of the class of 2021 in the sample universities, the reading breadth score of the students in the experimental group in current and contemporary literature reaches 3.72±0.61. The reading ability of the two groups of students shows a significant difference at the 1% level. Furthermore, students in the experimental group were 0.3 points more motivated to learn modern and contemporary literature than those in the control group. The integration of current and modern literature teaching with information technology can promote students’ learning interests and improve the quality of current and contemporary literature teaching.
Exploring the gray correlation analysis of student management and ideological and political education in colleges and universities
Authors: Jiang Mingsi 
Published: April 2024

Abstract
This paper takes grey correlation analysis as the theoretical basis and improves the original grey proximity correlation calculation method by adding bias terms. Uniformly select multiple sample datasets so that the proportion of positive and negative samples is roughly equal. Use the BiasGA method to calculate the biased grey correlation between users and other users to obtain the biased grey correlation matrix of users. Determine if there is a link between student management and ideological and political education by setting the correlation threshold. Integration of teaching cases and feasibility analysis led to the results being found. Teachers under 35 account for 68.75% of the total proportion. The teacher team tends to be younger, and they lack experience in ideological and political management. In student management, only a small number of teachers can improve the effectiveness of student management with the guidance of ideological and political education. the performance evaluation values of the five teachers were 72, 63, 72, 58, 61, respectively. The teachers did not do a comprehensive job of integrating the concept of ideological and political education into the management of students in colleges and universities. Daily affairs management should be strengthened in managing students in colleges and universities, and the integration of ideological and political education concepts should be emphasised.
Research on digital rural landscape garden landscape planning under rural revitalization strategy based on topological data analysis method
Authors: Yanli Song , Hui Zhang 
Published: April 2024

Abstract
The advancement of rural revitalization strategies underscores the increasing significance of landscape garden construction. This study optimizes scenic road routing within rural garden planning to support these strategies. By refining the topological data analysis method with Particle Swarm Optimization (PSO), we develop a model for rural scenic road routing. The model utilizes selected suitability indexes, organized through factor analysis into four categories: scenic, land, industrial resources, and infrastructure. Applied to a case study (Route Z), the model identifies Route 2 as the most suitable option, scoring 2.933. Our findings offer innovative insights and technical approaches for effectively planning rural scenic roads, contributing to countryside revitalization efforts.
Research on e-commerce customer value mining based on K-means clustering algorithm
Authors: Wang Lidong 
Published: April 2024

Abstract
In the era of e-commerce economy, how to mine and study the different values of customers is an essential factor affecting the development of e-commerce enterprises. Based on this, this paper uses a clustering algorithm to mine and study the value of e-commerce customers. The research firstly constructs RFM e-commerce customer value identification framework, designs e-commerce customer value evaluation indexes and calculates the weights of the value indexes, and then uses K-means clustering algorithm and classical artificial bee colony algorithm to improve the Calculation, and completes e-commerce customer refinement based on the value of the user. The results show that the type of e-commerce customer value based on the RFMC model can be divided into eight types, based on which the e-commerce customer value is further subdivided into four types by using the clustering algorithm, namely, core customers (13.86%), supportive customers (45.38%), habitual customers (21.08%) and risky customers (19.68%). Based on the clustering algorithm, the customer value was classified into type 0 customers (low value customers), type 1 customers (high value customers), and type 2 customers (medium value customers).
Exploration of Factors Influencing the Psychological Adjustment of First-Year College Students Based on Multivariate Data Analysis
Authors: Wang Changhe 
Published: April 2024

Abstract
This study emphasizes the critical role of psychological adaptation in the growth and development of college students, a cornerstone of successful higher education. We identify critical challenges by exploring first-year students’ psychological adjustments to their new academic environments and propose targeted strategies to enhance their integration into university life. Utilizing a questionnaire-based analysis to pinpoint areas of psychological misadjustment, our research offers practical solutions to facilitate smoother transitions for students, thereby improving the overall effectiveness of college education.
Impact of Strategical Sustainability on Real Estate Industry’s Sustainability Performance
Authors: Sanchaniya Rashmi Jaymin , Geipele Ineta 
Published: April 2024

Abstract
The primary aim of this research is to investigate the relationship between strategic sustainability and firm success within the real estate sector. Specifically, it aims to assess how strategic sustainability factors, notably business strategy and management, influence sustainability performance. By exploring this uncharted territory, the study seeks to provide insights into the role of strategic sustainability in enhancing an intangible value in terms of sustainability performance. Through quantitative data gathered from the Latvian real estate industry, the research study demonstrates that greater emphasis on business strategy efforts and activities is positively associated with improved sustainability performance. Moreover, it establishes a correlation between enhanced management practices and higher sustainability performance. Ultimately, this research contributes to our understanding of how strategic sustainability can drive the long-term sustainability and success of real estate businesses, benefitting regions, nations, and the global community.
Long non-coding RNA-AK138945 regulates myocardial ischemia-reperfusion injury via the miR-1-GRP94 signaling pathway
Authors: Wang Yanying , Huang Jian , Sun Han , Liu Jie , Shao Yingchun , Gong Manyu , Yang Xuewen , Liu Dongping , Wang Zhuo , Li Haodong , Zhang Yanwei , Zhang Xiyang , Du Zhiyuan , Leng Xiaoping , Jiao Lei , Zhang Ying 
Published: April 2024

Abstract

Objective
Myocardial ischemia-reperfusion injury (MIRI) is one of the leading causes of death from cardiovascular disease in humans, especially in individuals exposed to cold environments. Long non-coding RNAs (lncRNAs) regulate MIRI through multiple mechanisms.This study explored the regulatory effect of lncRNA-AK138945 on myocardial ischemia-reperfusion injury and its mechanism.

Methods

In vivo, 8- to 12-weeks-old C57BL/6 male mice underwent ligation of the left anterior descending coronary artery for 50 minutes followed by reperfusion for 48 hours. In vitro, the primary cultured neonatal mouse ventricular cardiomyocytes (NMVCs) were treated with 100 μmol/L hydrogen peroxide (H2O2). The knockdown of lncRNA-AK138945 was evaluated to detect cardiomyocyte apoptosis, and a glucose-regulated, endoplasmic reticulum stress-related protein 94 (GRP94) inhibitor was used to detect myocardial injury.

Results
We found that the expression level of lncRNA-AK138945 was reduced in MIRI mouse heart tissue and H2O2-treated cardiomyocytes. Moreover, the proportion of apoptosis in cardiomyocytes increased after lncRNA-AK138945 was silenced. The expression level of Bcl2 protein was decreased, and the expression level of Bad, Caspase 9 and Caspase 3 protein was increased. Our further study found that miR-1a-3p is a direct target of lncRNA-AK138945, after lncRNA-AK138945 was silenced in cardiomyocytes, the expression level of miR-1a-3p was increased while the expression level of its downstream protein GRP94 was decreased. Interestingly, treatment with a GRP94 inhibitor (PU-WS13) intensified H2O2-induced cardiomyocyte apoptosis. After overexpression of FOXO3, the expression levels of lncRNA-AK138945 and GRP94 were increased, while the expression levels of miR-1a-3p were decreased.

Conclusion
LncRNA-AK138945 inhibits GRP94 expression by regulating miR-1a-3p, leading to cardiomyocyte apoptosis. The transcription factor Forkhead Box Protein O3 (FOXO3) participates in cardiomyocyte apoptosis induced by endoplasmic reticulum stress through up-regulation of lncRNA-AK138945.
Notum protects against myocardial infarction-induced heart dysfunction by alleviating cardiac fibrosis
Authors: Jin Tongzhu , Ye Zhen , Fang Ruonan , Li Yue , Su Wei , Wang Qianqian , Li Tianyu , Shan Hongli , Lu Yanjie , Liang Haihai 
Published: April 2024

Abstract

Background and Objective
Cardiac fibrosis is a pathological reparative process that follows myocardial infarctionand is associated with compromised cardiac systolic and reduced cardiac compliance. The Wnt signaling pathway is closely implicated in organ fibrosis, and Notum, a highly conserved secreted inhibitor, modulates Wnt signaling. The objective of this study was to explore the role and mechanism of Notum in cardiac fibrosis.

Methods
A mouse model of cardiac remodeling was established through left coronary artery ligation surgery, with the addition of Notum injection following myocardial infarction surgery. The protective effect of Notum on myocardial infarction was assessed by evaluating cardiac function, including survival rate, echocardiographic assessment, and cardiac contraction analyses. Inflammatory cell necrosis and infiltration were confirmed through H&E and Masson staining. The expression of fibrosis-related genes and β-catenin pathway markers was detected using Western blot quantificational RT-PCR (qRT-PCR). Additionally, EdU, wound healing, and immunofluorescence staining analyses were performed to detect the effect of Notum’s in transforming growth factor beta-1 (TGF-β1) induced myofibroblast transformation.

Results
The administration of Notum treatment resulted in enhanced survival rates, improved cardiac function, and decreased necrosis and infiltration of inflammatory cells in mice subjected to left coronary artery ligation. Furthermore, Notum effectively impeded the senescence of cardiac fibroblasts and hindered their pathological transformation into cardiac fibroblasts. Additionally, it significantly reduced collagen production and attenuated the activation of the Wnt/β-catenin pathway. Our preliminary investigations successfully demonstrated the therapeutic potential of Notum in both fibroblasts in vitro and in a mouse model of myocardial infarction-induced cardiac fibrosis in vivo.

Conclusion
Notum inhibition of the Wnt/β-catenin signaling pathway and cardiac fibroblast senescence ultimately hampers the onset of cardiac fibrosis. Our findings suggest that Notum could represent a new therapeutic strategy for the treatment of cardiac fibrosis.
Impact of Internet of Things (IoT) on Enhancing Transparency and Efficiency in Bangladesh's Agri-food Supply Chain
Authors: Hasan Ikram , Mohamed Zulkifflee , Habib Md. Mamun , Hanafi Hasinah Bt. Mohd 
Published: April 2024

Background: The agri-food supply chain in Bangladesh is crucial for the nation's sustenance and economic stability but faces challenges like lack of transparency, inefficiencies, and information asymmetry. The integration of Internet of Things (IoT) technologies offers transformative potential, enhancing the Transparent Physical and Information Flow (PHF) and thereby influencing the Transparency in the Agri-food Supply Chain (TASC).

Objective: This study aims to investigate the impact of IoT integration on PHF and its subsequent effect on TASC in Bangladesh, framed around two core hypotheses: the significant influence of IoT on PHF and the consequent impact of an IoT-enhanced PHF on TASC.

Methods: Employing a comprehensive methodological framework, the study utilized IBM SPSS for exploratory factor analysis and IBM AMOS for confirmatory factor analysis (CFA) and structural equation modeling (SEM) to assess the relationships between IoT technologies, PHF, and TASC. The analysis was based on data collected from 400 respondents in Bangladesh's agriculture sector.

Results and Conclusion: The findings validate both hypotheses, demonstrating a significant and positive impact of IoT technologies on PHF and, subsequently, on TASC. The results highlight the crucial role of IoT in enhancing supply chain transparency and operational efficiency.

Implications of the Research: This research provides empirical evidence on the effectiveness of IoT technologies in addressing transparency issues within the agri-food supply chain. It underscores the potential of IoT to foster improved decision-making, efficiency, and consumer trust in the agricultural sector, particularly in developing contexts like Bangladesh.

Originality/Value: This study contributes original insights into the role of IoT technologies in enhancing the agri-food supply chain's transparency and efficiency. By focusing on the context of Bangladesh, it offers valuable implications for policymakers, industry practitioners, and researchers, emphasizing the transformative potential of IoT in agricultural supply chain management.
Academic Path Linked to Research and Extension: The Experience of the Remote Experimentation Laboratory (Rexlab) of The Federal University of Santa Catarina
Authors: Silva Juarez Bento da , Silva Isabela Nardi da , Bilessimo Simone Meister Sommer , Alves João Bosco da Mota 
Published: April 2024

Objective: This study aims to investigate the trajectory and contributions of the Remote Experimentation Laboratory (RExLab) over its 27 years of existence, focusing on the integration of technology in education and its relevance to teaching and learning. Theoretical Framework: RExLab was founded in 1997 with the aim of promoting digital inclusion and democratization of science education through the provision of Remote Laboratories. Over the years, the research group has added more resources to its projects, such as the integration of technologies in education, teacher training, and the creation of Open Educational Resources (OER), receiving several awards and distinctions along the way. Method: The research adopted a documentary and bibliographical approach, tracking the evolution and impact of RExLab from its inception to the present moment. Data collection was conducted through the analysis of documents and publications related to RExLab. Results and Discussion: The results highlight RExLab's contributions to the integration of technology in education, demonstrating its role in generating practical knowledge to solve specific problems and in understanding the experiences and perceptions related to technology in education. The discussion contextualizes these results in light of the theoretical framework, emphasizing the importance of RExLab for teaching and learning. Research Implications: This research reflects on how RExLab can continue to be an ally in the integration of technology in education, even in the face of future challenges. Its implications encompass both the field of education and applied research. Originality/Value: This study contributes to the literature by highlighting the importance of RExLab as a successful model in the integration of technology in education over time. Its relevance lies in the emphasis on the practical application of research and in promoting equality through education.
The Influence of Biologically Synthesized Copper Nanoparticles on the Biofilm Produced by Staphylococcus haemolyticus 1solated from Seminal Fluid
Authors: Romi Zahraa Mahmoud , Ahmed Mais Emad 
Published: April 2024

Staphylococcus haemolyticus is one of the most frequently isolated coagulase-negative staphylococci. The ability to form biofilm is considered as one of the most important virulence factors of coagulase negative staphylococci. There is only limited knowledge of the nature of S. haemolyticus biofilms. This study was aimed at evaluating the ability of S. haemolyticus strains to produce biofilm in the presence of copper oxide nanoparticles (CuONPs). The biological synthesis of nanoparticles is an environmentally friendly approach for large-scale production of nanoparticles. Copper oxide nanoparticles were produced in the current study from the S. haemolyticus viable cell filtrate. UV-visible (UV-Vis) spectroscopy, X-ray diffraction (XRD), atomic force microscope (AFM), field emission scanning electron microscope (FE-SEM), energy-dispersive X-ray spectroscopy (EDX) and zeta potential (ZP) analysis were used to analyze the newly synthesized CuONPs. Our findings revealed that at minimum inhibitory concentration (MIC), CuONPs showed remarkable inhibition on the biofilms produced by multidrug resistant (MDR) S. haemolyticus isolates.
Evaluation of nail fold capillaroscopy changes in patients with diabetic retinopathy and healthy controls, and its correlation with disease duration, HbA1c levels and severity of diabetic retinopathy: An observational study
Authors: Mahajan Mohita , Kaur Tejinder , Singh Karamjit , Mahajan B.B. 
Published: April 2024

Background
Diabetic retinopathy (DR) is an important microvascular complication of long-term type 2 diabetes mellitus (T2DM) leading to blindness if not properly diagnosed and managed. It can develop as early as 7 years before the diagnosis of diabetes. Nail fold capillaroscopy (NFC) is a non-invasive technique for observing capillary microvasculature and there are few studies which have explored the use of NFC in diabetes mellitus patients.

Objective
To study the nail fold capillaroscopic alterations in patients with T2DM having diabetic retinopathy and compare them to healthy controls. The secondary objective was to correlate the NFC findings with the duration of diabetes, haemoglobin A1c (HbA1c) levels and the severity of DR.

Materials and methods
This cross-sectional observational study enrolled 200 patients - 100 cases with T2DM having diabetic retinopathy (as per the American Diabetes Association criteria and Diabetic Retinopathy Disease Severity Scale) and 100 healthy age and sex-matched controls. All patients were subjected to NFC and ophthalmological assessment.

Results
NFC revealed that patients with DR showed significantly higher frequencies of tortuous, dilated, bushy, meandering, angulated capillaries, avascular areas and micro-haemorrhages as compared to healthy controls (p < 0.05). In proliferative DR (PDR), the frequency of tortuous, bushy capillaries, and avascular areas was statistically high and the capillary density was reduced as compared to non-proliferative DR. The DR patients with longer disease duration (>20) years had a significantly higher frequency of tortuous capillaries, avascular areas, meandering, angulated and dilated capillaries. The frequency of tortuosity, avascular areas, and bushy areas was significantly higher in patients with poor glycaemic control (HbA1c >11).

Limitations
A larger sample size study with different demographic populations could have provided a broader picture of NFC changes in T2DM patients with DR.

Discussion
NFC may act as a surrogate marker of retinal involvement in patients with DM and should be performed at regular intervals.

Conclusion
NFC is a quick, simple, safe, and non-invasive method to assess the capillaroscopic alterations in diabetic patients which inturn can help in assessing the severity of DR.
Implementing Blockchain For Publishing and Verifying Digital Certificates On EduTech
Authors: Maroso Akwan , Angreni Dwi Shinta , Ardiansyah Rizka , Dwiwijaya Kadek Agus 
Published: April 2024

This study investigates the application of blockchain technology in enhancing the security and authenticity of digital certificates. Addressing key challenges such as fraud and the lack of a standardized verification process, the paper proposes a comprehensive framework aimed at fortifying the integrity of digital credentials. This framework is the utilization of blockchain as a distributed ledger, serving as a tamper-proof repository for recording certification transactions. Through this decentralized ledger, each certification issuance and verification action is securely recorded, enhancing trust and transparency in the certification process. The methodology includes the integration of a decentralized ledger for immutable record-keeping and implementation of smart contracts for automated authenticity checks, and the use of cryptographic measures to ensure data security. This approach promises significant implications for various sectors reliant on credential verification, advocating for a broader adoption of blockchain in digital certificates systems.