bluuebunny/crossref_metadata_2025_split huggingface dataset:
FACTORS ASSOCIATED WITH TUBERCULOSIS-DIABETES MELLITUS COMORBIDITY
Authors: Nugrahaeni Dyan Kunthi , Kusumasari Ika , Budiana Teguh Akbar , Mauliku Novie Elvinawaty 
Published: February 2025

Background: The double burden disease refers to the increase of communicable and non-communicable disease, such as comorbidity tuberculosis (TB) with diabetes mellitus (DM). If not treated properly and managed, tuberculosis can lead to comorbidity with diabetes mellitus. Purpose: This research aims to determine factors associated with tuberculosis-diabetes mellitus comorbidity. Methods: Research design used case-control study, sample cases are TB patients with DM as many as 15 people, while sample control is TB patient without DM as many as 30 people. Independent variables include age, education, occupation, TB severity, body mass index, and quality of life, while the dependent variable is comorbidity TB-DM. The instrument used the World Health Organization’s Quality of Life Brief Version (WHOQOL-BREF). Data analysis was performed utilizing the Chi-Square test and Independent T-test. Results: This study’s findings indicated that the variable age (p= 0.011; OR= 6; 95% CI= 1.39-25.85), education (p=0.03; OR= 4.12; 95% CI= 1.06-16.03), TB severity (p= 0.02; OR= 4.57; 95% CI= 1.18-17.67), and quality of life domains were significantly related to TB-DM with comorbidity: physical (p=0.00; OR=42.25; 95%CI=6.82-261.61), psychological (p=0.03; OR=4; 95% CI=1.07-14.89) and environmental domain (p=0.01; OR=10.54; 95% CI=1.06-105.03). Conclusion: Factors influencing comorbidity between TB-DM include age, education level, TB severity and quality of life. Enhancing immunity in TB patients is essential to reduce the severity of TB and comorbidity of TB-DM, with recommendations for support from family, parents, children, and friends to improve the quality of life for those with TB-DM.
IDENTIFYING RISK FACTORS FOR THE SPREAD OF DRUG-RESISTANT TUBERCULOSIS IN LAMPUNG IN 2023: A CASE-CONTROL STUDY
Authors: Awaliyah Kharismatul , Farich Achmad , Muhani Nova , Amirus Khoidar , Eka Sari Siregar Fitri 
Published: February 2025

Background: Drug-resistant tuberculosis (DR-TB) is a growing health concern in Lampung, where the low rate of DR-TB case detection and high treatment failure rates emphasize the necessity of identifying risk factors to strengthen control measures for DR-TB. Purpose: This study aimed to identify the dominant risk factors for the spread of drug-resistant tuberculosis among patients in Lampung Province in 2023. Methods: Using a case-control study design, the research utilized secondary data from the Tuberculosis Information System (SITB) Lampung Province. A total sampling method was employed, with 126 respondents in the case group and a 1:1 ratio, making the total sample size 252 respondents. Data matching was done for gender and age variables. Statistical analysis included univariate, bivariate chi-square, and multivariate logistic regression tests. Results: Univariate analysis showed that 57.90% of respondents were male, 57.90% were in the at-risk age group, 58.30% were employed, 81.30% did not have diabetes (DM) comorbidity, 97,20% did not have HIV comorbidity, 67,50% had no prior TB treatment history. Bivariate analysis indicated significant associations with occupation (p-value 0.04), DM comorbidity (p-value 0.02), and treatment history (p-value 0.00). Gender, age, and HIV comorbidity showed no significant associations. The multivariate analysis showed a significant effect of the TB treatment history variable (p-value 0.00, OR=9.04) and the HIV comorbidity variable (p-value 0.03, OR= 0.08). Conclusion: TB treatment history is the dominant factor that can affect the spread of drug-resistant tuberculosis in Lampung Province in 2023. Future researchers are encouraged to focus on studying the types of treatment failures.
PENGEMBANGAN E-MODUL HIDROLISIS GARAM BERBASIS ETNOSCIENCE DENGAN MODEL SCIENTIFIC CRITICAL THINKING (ETNO-SCT) UNTUK MENINGKATKAN KETERAMPILAN PROSES SAINS DAN HASIL BELAJAR PENGETAHUAN PESERTA DIDIK
Authors: Pratiwi Diyah Intan , Bakti Iriani , Syahmani Syahmani 
Published: February 2025

Penelitian ini bertujuan untuk mengembangkan e-modul hidrolisis garam berbasis Etno-SCT yang valid, praktis, dan efektif untuk meningkatkan keterampilan proses sains dan hasil belajar pengetahuan peserta didik. Metode penelitian yang digunakan adalah Research and Development (R&D) dengan model ADDIE (Analyze, Design, Development, Implementation and Evaluation). Subjek penelitian adalah 5 orang validator dan peserta didik kelas XI MIPA 1 SMA Negeri 8 Banjarmasin berjumlah 32 orang. Teknik pengumpulan data menggunakan lembar validasi, angket keterbacaan, angket respon, lembar observasi, dan instrumen tes. Analisis data yang digunakan adalah analisis deskriptif. Hasil penelitian menunjukkan bahwa validitas e-modul sebesar 94,66% dengan kategori sangat valid ditinjau dari aspek isi, penyajian, bahasa dan media. Kepraktisan e-modul dilihat dari tingkat keterbacaan dalam kategori sangat baik, hasil angket respon peserta didik dan guru pada kategori sangat baik, serta hasil observasi kemampuan guru dalam menggunakan e-modul dan keterlaksanaan pembelajaran berkategori sangat baik. Keefektifan e-modul dilihat berdasarkan nilai N-gain keterampilan proses sains sebesar 0,75 (tinggi) dan hasil belajar pengetahuan sebesar 0,78 (tinggi). E-modul hidrolisis garam berbasis Etno-SCT ini telah memenuhi kriteria valid, praktis, dan efektif sehingga layak digunakan sebagai bahan ajar untuk meningkatkan keterampilan proses sains dan hasil belajar pengetahuan peserta didik dalam pembelajaran kimia.
Carbon footprint awareness of nursing students: A qualitative study
Authors: KAŞIKÇI Mağfiret , BAĞCI Yeşim , YILDIRIM Zeynep , NACAK Ulviye Aydan 
Published: February 2025

Abstract

Backround:
The increasing impact of climate change on public and environmental health underscores the importance of understanding carbon footprints and adopting sustainable practices. Nursing students play a critical role in promoting environmental awareness and integrating eco-friendly practices into healthcare delivery. This study aim to asses the awareness of nursing students about ‘Carbon Footprint’ and their suggestions for reducing carbon footprint
Design:
Qualitative study.
Methods
Sixty fourth-year nursing students enrolled in the "Public Health Nursing" course within the nursing department from a a university located in eastern Turkey participated in this study. Twelve face-to-face interviews were conducted. Transcripts were subjected to structured qualitative content analysis.
Results
As a result of the analysis of the data obtained from the participants, two main themes as ‘Awareness of Carbon Footprint’ and ‘Measures to Reduce Carbon Footprint’, four sub-themes as ‘Effects on Human Health’, ‘Effects on Environmental Health’, ‘Individual Measures’ and ‘Institutional Measures’ and eighteen codes in total were created.
Conclusion
This study revealed that nursing students possess a fundamental awareness of the carbon footprint and its implications for human and environmental health. Integrating comprehensive environmental education into nursing curricula can empower future healthcare professionals to adopt and advocate for sustainable practices in both personal and professional domains.
Vulnerability of Global Afforestation Projects to a Polyphagous Invasive Fall Webworm
Authors: Zhao Lilin , Ning Jing , Du Jingjing , Lu Deliang , Chen Jiquan , Wang Hui , Hao Dejun , Fan Jianting , Guo Lei , Song Wei 
Published: February 2025

Abstract

Global plantations, crucial for restoring degraded landscapes, face rising invasive pest threats, in recent decades. This study highlights that the invasion and proliferation of the fall webworm have been facilitated by the global afforestation boom in the last 80 years and could pose a threat to all global ecological projects until 2050. Since 1940, this polyphagous pest has spread to 40 countries, following an S-curve pattern. The distribution of the fall webworm is positively correlated with the expansion rates of afforestation and host tree plantation areas. China is now the most affected country by the fall webworm, with the highest comprehensive threat index (CTI). The number of host species has risen from 121 in the U.S. to 400 in China, and the host range has expanded from hardwoods to include coniferous trees. Notably, two-thirds of the total 600 host plants are tree species utilized for afforestation purposes. The preferred host species, Acer, Quercus, and Populus, are predominant in eight major global ecological projects. Additionally, hydroclimate extremes are projected to increase threats to 65.8% of afforestation zones by 2070, highlighting the need for strategic tree species selection to achieve sustainable ecological goals of global ecological projects, and protect against pests.
Per2 deficiency in microglia alleviates motor dysfunction by inhibiting ferroptosis in spinal cord injury
Authors: Bie Pengfei , Su Dongpo , Gao Yang , Wu Liang , Niu Zhanfeng , Zhao Yanbin , He He , Jiang Zhanfeng , Zeng Zhong , Zhang Yaolin , Fan Heng , Xia Hechun 
Published: February 2025

Abstract

Microglia are specialized resident immune cells of the central nervous system parenchyma that mediate reactions such as the inflammatory response to spinal cord injury (SCI) and play significant roles in exacerbating or alleviating disease progression. Previous studies have suggested that ferroptosis, a newly discovered form of regulated necrotic cell death, plays a crucial role in exacerbating neuronal dysfunction and loss following SCI; however, the role of microglial ferroptosis in SCI and the underlying mechanisms remain elusive. Here, we elucidate that lipid droplets accumulate in microglia to facilitate ferroptosis of microglia after SCI. Notably, microglial ferroptosis peaks at 3 days post-injury, after which it decreases. Microglial Period 2 (Per2) expression is elevated after SCI in vivo, this change is highly synchronized with the changes in microglial ferroptosis. Using conditional knockout mice, we observed that microglia-specific Per2 knockout promoted neurological function recovery by suppressing microglial ferroptosis. In vitro, Per2 overexpression and deficiency amplified and mitigated microglial ferroptosis, respectively. Using RNA-seq analysis, we found that Gpx4 was downregulated by Per2. Coimmunoprecipitation (Co-IP) demonstrated that Per2 directly interacted with PPARα to further regulate Gpx4. Furthermore, we demonstrated that the degree of microglial ferroptosis was decreased and that the number of microglia was increased by treatment with a ferroptosis inhibitor, which indicated that reducing microglial ferroptosis during the acute phase of SCI may be beneficial for alleviating neurological dysfunction. Overall, our results indicate that Per2 determines the susceptibility of microglia to ferroptosis via the PPARα-Gpx4 axis, and suggest that Per2 has potential as a therapeutic strategy to alleviate motor dysfunction by inhibiting microglial ferroptosis following SCI.
OsbZIP35 Interacts with OsSAPK3 and Enhances Drought Stress Tolerance and Yield in Rice
Authors: Lou Dengji , Zhang Xiaoxuan , Chen Zhen , Wang Yiling , Yu Diqiu , Yang Xiaoyan 
Published: February 2025

Abstract

OsbZIP35 is a member of the B subfamily of bZIP transcription factors in rice (Oryza sativa L.). The function of OsbZIP35 has not been reported previously. In this study, drought, H2O2, abscisic acid, and NaCl treatments strongly induced the expression of OsbZIP35, whereas treatment with gibberellin, indoleacetic acid, and jasmonic acid did not affect OsbZIP35 expression. We used the CRISPR/Cas9 gene-editing technology to construct OsbZIP35 knockout mutants (bzip35-1 and bzip35-2) and evaluated the function of OsbZIP35. The results showed that, compared with the wild type, the bzip35 mutants were more sensitive to drought stress during the germination, post-germination growth, and seedling stages. Specifically, the bzip35 mutants exhibited a lower germination percentage, a weaker growth phenotype, and an increase in reactive oxygen species accumulation. Further analysis indicated that, under drought stress, OsbZIP35 regulated reactive oxygen species accumulation by modulating the contents of antioxidants, thereby positively regulating the response of rice seedlings to drought stress. In addition, we observed that OsbZIP35 could be phosphorylated by OsSAPK3 and participated in the abscisic acid signaling pathway in response to drought stress. Agronomic trait analysis revealed that, under drought stress at the heading stage, the panicle length and seed-set rate of bzip35 mutants were significantly lower than those of the wild type. This study examined the role of OsbZIP35 in rice stress tolerance and yield regulation, and identified an upstream regulatory gene, OsSAPK3. The results provide novel information on the mechanisms of stress tolerance and yield regulation in rice.
The Influence of Green Technology Innovation and Renawable Energy Consumption on Environment Quality in Indonesia
Authors: Gunawan Rio Deny Andre 
Published: February 2025

Abstract

Environmental degradation is currently the most talked about issue around the world. Climate change and global warming are indicators of this damage. Carbon emissions are one of the main causes of global warming. In 2001, Indonesia ranked 21st as the country with the largest CO2 gas emissions. In 1990, the total emissions resulting from fossil fuel combustion reached about 83.8 million tons, and are expected to increase to 368.3 million tons by the end of 2020. By 2022 Indonesia ranks 7th in the world. In 2024, Jakarta ranked 4th as the capital city with the worst air quality in the world. This study aims to analyze the effect of Green Technology Innovation, Renewable Energy Consumption, GDP, and FDI on Carbon Emissions in Indonesia using the Autoregressive Distributed Lag (ARDL) method. The results showed that the Green Technology Innovation variable had a significant negative effect, the Renewable Energy Consumption variable had a significant negative effect, the GDP variable had a significant positive effect while FDI had a no effect.
Palladium-Catalyzed Heck Cyclization/Reductive Aminocarbonylation of Carbamoyl Chlorides with Nitroarenes
Authors: Gong Jia-Yi , Wang Zi-Yi , Cui Zi-Yi , Liu Jin-Jing , Zhou Zhe , Gao Xin , Chen Chen , Ni Chunjie , Zhu Bolin 
Published: February 2025

Abstract:
A palladium-catalyzed Heck cyclization/reductive aminocarbonylation was developed for
alkene-tethered carbamoyl chlorides with nitroarenes using Mo(CO)6 as a convenient CO surrogate
and reductant. This process constructed one C–N bond and two C–C bonds, yielding a variety of
amidated oxindoles/γ-lactams with an all-carbon quaternary stereocenter under gas-free conditions.
The transformation exhibited a wide range of substrate compatibility and exceptional functional
group tolerance.
Systemic Sclerosis Complicated by Rapidly Progressive Osteomyelitis: A Case Report
Authors: Nigro Angelo 
Published: February 2025

Background:
Systemic sclerosis (SSc) is an autoimmune disorder characterized
by progressive fibrosis and vascular complications. Osteomyelitis is a rare but serious complication
in patients with systemic sclerosis, particularly those with advanced vascular compromise.
This case is notable for the rapid progression of osteomyelitis and highlights the importance of early
intervention and thorough clinical monitoring.

Case Presentation:
We report the case of a 68-year-old female with SSc (Scl-70 positive), treated
with iloprost IV, nifedipine, bosentan, prednisone, and mycophenolate for pulmonary involvement.
In January 2024, she developed acrocyanosis and severe pain in the fifth toe of the right
foot. A small ulcer formed, and subsequent radiographic evaluation revealed rapid progression of
osteolysis. Despite negative culture swabs, an infectious process was suspected, and combination
antibiotic therapy was initiated. This treatment led to a gradual resolution of symptoms, with subsequent
imaging showing detachment of the fifth toe.

Conclusion:
This case highlights the critical need for vigilant radiographic monitoring and timely
antibiotic intervention in patients with SSc who develop vascular complications. Early diagnosis
and treatment are crucial for optimizing patient outcomes and preventing severe bone damage.
Design, Synthesis, Characterization, and Antitumor Activities of
Benzimidazole-functionalized Organoruthenium Complexes Bearing
Fluorine Group
Authors: Paşahan Ramazan , Demirci Özlem , Taşkın Irmak İçen , Paşahan Aziz , Sever Meryem Rüveyda , Gök Yetkin , Aktaş Aydın 
Published: February 2025

Background:
This work presents the synthesis of Ru(II)NHC complexes bearing a
series of 4-fluorobenzyl group. These complexes have been characterized by a variety of spectroscopic
methods (1H NMR, 13C NMR, and FTIR) and by elemental analysis techniques.

Methods:
These complexes' antitumor activities against SH-SY5Y (human neuroblastoma) and
HCT116 (human colon cancer) were investigated by 3-(4,5-dimethylthiazole-2-yl)-2,5-biphenyl
tetrazolium bromide (MTT) assay.

Results:
The results showed that all the synthesized complexes exhibited significant cytotoxic
effect with low IC50 values 15 ± 0.57, 15.26 ± 0.71, 7.64 ± 0.30, 27.66 ± 0.36 and 14.45 ± 0.84
(μg/mL) respectively.

Conclusion:
Furthermore, apoptosis assessed by double labeling with Annexin V-FITC/PI indicated
that complexes 1b and 1d can effectively induce apoptosis and inhibit cell proliferation at
the S phase in SH-SY5Y cells. Taken together, Ru(II)NHC complexes containing the 4-
fluorobenzyl group have significant potential for the development of novel, highly effective anticancer
agents.
Long-term Sustained Response to Lenalidomide after Clearance of Bone Marrow Blasts by Azacytidine in High-risk Myelodysplastic Syndromes with Del5q: A Case Report.
Authors: Niscola Pasquale , Giovannini Marco , Gianfelici Valentina , Mazzone Carla , de Fabritiis Paolo , Oliva Esther Natalie 
Published: February 2025

Introduction:
This report discusses a rare case involving a patient with high-risk (HR)
Del(5q) myelodysplastic syndrome (MDS) who achieved a long-term response to lenalidomide after
having received six cycles of azacytidine. The latter treatment led to the clearance of blast cells
from the bone marrow (BM).

Case Representation:
As per current clinical practice, patients with HR MDS receive azacytidine
continuously until the disease progresses or the occurrence of unmanageable side effects. However,
in this case, the patient decided to interrupt hypomethylation therapy. Due to the patient's preference
for oral therapy at home, the absence of blast cells, the ongoing need for transfusions, and
a cytogenetic abnormality-predictive response to lenalidomide, the choice of the latter agent allowed
for a sustained response lasting up to 68 months.

Conclusion:
Our observations suggest that further studies could explore the sequential use of azacytidine
followed by lenalidomide after achieving BM blast clearance in patients with HR MDS
with del(5q).
Shaping Dignities – A pluralistic and relational approach to dignity using arts-based methods
Authors: Benitez-Schaefer Florencia 
Published: February 2025

Summary
While the concept of ‘dignity’ builds a cornerstone of Human Rights, as well as international and national legal structures, it has been critiqued since its inception, particularly in regards to issues of diversity. This paper argues that, if we aim to respond to the major ongoing struggles, we need to enhance our awareness about different approaches to dignity that coexist but are not equally attended or represented in the legal field. In this vein, I propose an exercise and utilize the experience of an arts-based workshop conducted recently with social scientists on the issue as material to explore different shapes of dignity. In order to engage with this material, I introduce approaches of the field of Peace Studies (Many Peaces Theory by Wolfgang Dietrich) and contemporary political philosophy (Donna Haraway), as helpful theoretical frameworks. On this base, I propose that a revised view on dignity can offer us a more relational, integrative and useful perspective in the field of law and Human Rights.
If Late, then Never or Not likely: Uptake of Orientation and Mobility Rehabilitation Training (OMRT) Among Visually Impaired Older Adults
Authors: Okonji Emeka Patrick , Connors M. Elyse , Akinsola Jonadab Oluwatosin , Ogwezzy Darlignton Chukwunalu , Durugo Samuel Ogechukwu , Leja James 
Published: February 2025

Abstract
Background: Visually impaired people have challenges with outdoor mobility, which underscores the need for orientation and mobility rehabilitation training (OMRT). However, awareness and uptake of OMRT among blind people remain very low in Nigeria. The study investigated the association of demographic, physical, and visual impairment-related variables with awareness and uptake of orientation and mobility rehabilitation training (OMRT) in Nigeria
Methods: A cross-sectional survey of 361 visually impaired people aged 60 years and over, with best-corrected visual acuity ≤ 20/80 (0.6 LogMAR). The Timed Up and Go (TUG) test was used to assess the risks of falling. Multiple logistic regression was used to analyse predictors of awareness and uptake of OMRT
Results: Only 26.88% of those who were aware of OMRT reported accessing Orientation and mobility rehabilitation training (OMRT). The duration of visual impairment (p=0.016), awareness of the cause of Low Vision (p=0.043), and being at the risk of falls (p < 0.001), were significantly associated with taking-up OMRT.
Conclusion: Prolonged delays in referrals for OMRT are a potential cause of apathy towards the uptake of OMRT.
Intelligent Guide Robots for People who are Blind or have Low Vision: A Review
Authors: Thiyagarajan Karthick , Kodagoda Sarath , Luu Mark , Duggan-Harper Taliah , Ritchie Doug , Prentice Kelly , Martin Jodi 
Published: February 2025

Abstract
According to the World Health Organization, at least 2.2 billion people worldwide are blind or have some degree of near or distance vision impairment. Guide Dogs and other existing mobility aids are valuable tools to support travel and independence for these individuals. Nevertheless, the process of training dogs to be effective mobility aids is expensive, time-consuming, and requires highly specialised expertise. With technology making significant inroads into modern society, intelligent robots that are powered by smart sensing and advanced artificial intelligence present an opportunity to improve the mobility of those with blindness or low vision where access to a Guide Dog is not available. However, developing robust and effective robotic mobility aids with static and dynamic settings for use in both indoor and outdoor environments has remained a difficult task to accomplish. This article compares the capabilities of both existing robotic mobility aids, and existing cutting-edge robotic technologies, against a set of fundamental functional mobility aid characteristics with the aim of proposing a minimum viable product to support people who are blind or have low vision in everyday mobility and navigation tasks. The functional qualities identified and examined were sensing and interpretation, obstacle avoidance and object targeting, fluid and adaptable movement and navigation, interlink of device interface and sensing-interpretation unit, device interface to user, form factor and design. The outcomes of our study indicate that while existing robotic aids are limited in scope and focused on a narrow range of functions, existing cutting-edge robotic technologies have the potential to combine to create a fully-functioning robot guide. We propose a minimum viable product using these technologies as the next step towards a fully-functioning robot guide supporting the mobility and navigation of people who are blind or have low vision.