bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMPLEMENTASI KURIKULUM 2013 PADA MATA PELAJARAN AQIDAH AHLAK DI MADRASAH IBTIDAIYAH NURUL FALAH KECAMATAN KERITANG KABUPATEN INDAGIRI HILIR PROVINSI RIAU
Authors: Hutami Elsa Cahya , Asmarita Asmarita , Anillah Aksya 
Published: June 2024

Masalah umum yang dihadapi dalam penerapan kurikulum k13 adalah kurangnya sosialisai pada guru dan dukungan saranaprasarana untuk menunjang pembelajaran, serta kemampuan peserta didik yang masih kurang mampu untuk pembelajaran kurikulum k13. Sekolah Dasar MI Nurul Falah Pengalihan Keritang Adalah Sekolah Umum Yang Sudah Menerapkan Kurikulum K13 Meskipun sebagai sekolah umum pimpinan MI Nurul Falah memiliki harapan agar peserta didiknya memiliki karakter islami dan kemampuan keagamaan Islam yang lebih berbobot bila dibandingkan dengan sekolah umum yang sederajat. Demi mewujudkan harapan tersebut pimpinan MI Nurul Falah Pengalihan Keritang berupaya mengoptimalkan program mata pelajaran Akidah Akhlak dan pembiasaan keagamaan yang ada di sekolah. Tujuan penelitian ini untuk menganalisis kurikulum k13 yang di fokuskan pada mata pelajaran Akidah Akhlak Di MI Nurul Falah Pengalihan Keritang, meliputi perencanaan kurikulum, pelaksanaan Kurikulum, evaluasi Kurikulum. Penelitian ini adalah penelitian deskriptif kualitatif. Pengumpulan data menggunakan teknik wawancara, observasi, dan dokumentasi. Sumber data primer adalah Wakil Kepala Bidang Kurikulum, dan guru Mata Pelajaran Kidah Akhlak. Data dianalisa menggunakan teknik analisa data, reduksi data, dan penyajian data, serta menarik kesimpulan. Hasil penilaian menunjukkan bahwa mengoptimalkan pada mata pelajaran Akidah Akhlak pada jenjang kelas bawah 1 2 dan 3 masuk dalam mata pelajaran pendidikan agama islam dan pada kelas atas 4 5 dan 6 baru melaksanakan mata pelajaran Akidah Akhlak. Evaluasi dilakukan setiap enam bulan melibatkan seluruh tenaga pendidik dan kependidikan sekolah. Dari evaluasi ditemukan bahwa tujuan yang diharapkan sekolah sudah tercapai namun masih terdapat kendala seperti terbatasnya sarana prasarana dan kararkter peserta didik.
Analisis Rasio Liquiditas Terhadap Kinerja Keuangan PT Unilever
Authors: Anastasya Erika Yunita  , Chesya Anasha  , Mohammad Abdullah Al Fikri  , Dea sakinah  , Elfira Andi Darwis  , Jhon Winterpret  
Published: June 2024

Studi ini mengkaji kinerja keuangan PT Unilever Indonesia Tbk dengan tujuan untuk mengetahui tren pada PT Unilever Indonesia Tbk. Metode yang digunakan adalah kuantitatif dengan mengumpulkan dan memeriksa data numerik terkait dengan rasio likuiditas pada tahun 2021 dan 2022 dengan fokus pada likuiditas perusahaan. Analisis dilakukan melalui rasio likuiditas, yaitu rasio lancar dan rasio cepat. Hasilnya menunjukkan adanya tren penurunan likuiditas dari tahun 2021 ke tahun 2022. Rasio lancar turun dari 61,407% menjadi 60,823%, sementara rasio cepat turun dari 41,689% menjadi 39,724%. Penurunan ini mengindikasikan potensi beban yang lebih berat dalam membayar kewajiban jangka pendek. Evaluasi kinerja keuangan menjadi penting untuk memahami tantangan yang dihadapi perusahaan dan mengambil langkah-langkah yang tepat untuk meningkatkan kondisi keuangan.Bagian Atas FormulirTujuan dari menganalisis rasio likuiditas terhadap kinerja keuangan PT Unilever pada tahun 2021- 2022 yaitu mengidentifikasi tren likuiditas, menilai kesehatan keuangan, mengidentifikasi potensi keuangan, merumuskan langkah langkah perbaikan, dan mendukung pengambilan keputusan.
Healthcare provider's experience and attitude towards the national health insurance program of Nepal
Authors: Shrivastav Ganesh Kumar , Wungrath Jukkrit , Singweratham Noppcha 
Published: June 2024

Background: Universal Health Coverage (UHC) aims for accessible quality healthcare for all, without financial strain. Nepal's National Health Insurance Program (NHIP), launched in 2016, strives towards this goal by offering extensive healthcare services and financial protection against severe health costs. However, the NHIP encounters challenges, particularly with reimbursement processes and operational efficiency, which may impact its effectiveness and long-term viability.
Objectives: This study analyzed the situation regarding the experience, attitude, and recommendations of government and non-government Health Care Providers (HCPs) regarding the NHIP.
Methods: This Qualitative study carried out a qualitative analysis via in-depth interviews with 12 HCPs across three Nepalese provinces, assessing their experiences with the NHIP. Our method involved a culturally validated interview guide with 21 detailed questions. Interviews, conducted in Nepali, were translated and analysed through open coding to highlight key themes related to the NHIP's effectiveness and challenges.
Results: Aiming to assess the NHIP's service delivery impact, this study selected participants involved in the NHIP and analysed interview data to uncover themes concerning the NHIP's benefit package, the Insurance Management Information System (IMIS), coordination, and claim and reimbursement processes. The study revealed that the healthcare providers recognized the NHIP's benefits in increasing healthcare access and reducing financial burdens in Nepal yet point out limitations in covering complex diseases and financial sustainability for healthcare facilities. Key challenges include technical issues with IMIS and insufficient support from the Health Insurance Board [HIB].
Conclusion: Recommendations for enhancing the NHIP involve speeding up reimbursement, improving IMIS functionality, better coordination with the HIB, and revising the benefit package. Despite progress, significant hurdles in implementation and efficiency persist. Addressing these issues requires a multifaceted approach, including technological upgrades, policy adjustments, and enhanced training for healthcare workers. Optimizing the NHIP is essential for Nepal to achieve its UHC goals, ensuring equitable, accessible, and quality healthcare for all its citizens.
Factors associated with fruit and vegetable consumption among people in the highest risk area for Cholangiocarcinoma in Thailand
Authors: Sungtong Natpapat , Raksilp Monthicha , Songserm Assoc. Prof. Nopparat 
Published: June 2024

Background: Over the past 30 years, the incidence of cholangiocarcinoma (CCA) in the Northeast of Thailand has been high and has tended to increase. Fruits and vegetables (FV) were accepted as protective factors against CCA. The prevalence of FV consumption among Northeast people is lower than recommended, which is a significant health problem that must be urgently solved.
Objectives: This study investigated the factors associated with FV consumption among people in Ubon Ratchathani, one of the high-risk areas of Thailand.
Methods: A multi-stage sampling method was used to select the population aged 40 years and over. Data were analyzed using descriptive and inferential statistics. A logistic regression analysis was performed to identify the factors associated with FV consumption.
Results: Out of the total 744 respondents, only 11.83% consumed FV according to the standard of <400 grams/day. The bio-social factor regarding an average family income of more than 15,000 Baht had a 10.54 times greater effect on FV consumption (AOR=10.54, 95% CI: 7.59-20.57). Purchasing FVs from mobile sales trucks (AOR=4.11, 95% CI: 1.69-9.97) and receiving information from radio (AOR=1.97, 95% CI: 1.14-3.39) were associated with standard FV consumption. However, a good level of attitude had decreased the risk of FV consumption (AOR=0.30, 95% CI: 0.18-0.49).
Conclusion: The prevalence of FV consumption among the study population is considerably low. Family income, purchasing from mobile sales trucks, receiving information from radio, and having a positive attitude were associated with standard FV consumption among people in Thailand's highest-risk area for CCA. Relevant organizations should organize activities to provide people of every economic status with knowledge and attitude on FV consumption via radio or social media and support access to quality and safe mobile sales trucks to meet consumption standards and prevent as well as reduce the risk of CCA.
Kesatuan Eklesial di Tengah Budaya Individual Berdasarkan Filipi 2:1-4
Authors: Kalaka Jhon 
Published: June 2024

Budaya individualisme yang semula dikenal masif di dunia Barat perlahan mulai merata ke berbagai belahan dunia. Sikap semacam itu rupanya juga telah bersarang di kehidupan gereja masa kini. Individualisme mengarah pada narsisme dan pengabaian seorang akan yang lain. Namun kondisi ini sebetulnya bukan perkara baru. Di zaman gereja mula-mula telah ada hal semacam ini. Nasihat untuk kesatuan dalam Surat Filipi ditulis oleh Paulus untuk menangani adanya individualisme di antara jemaat Filipi yang menimbulkan perpecahan. Artikel ini meneliti Filipi 2:1-4 dalam perspektif eklesiologis guna menunjukkan bahwa Paulus membahas kesatuan eklesial yang pada gilirannya dapat dipakai untuk menangani gaya hidup individualistik. Pertanyaan penelitian yang layak diajukan ialah: apa saja prinsip-prinsip yang dibutuhkan untuk membangun kesatuan eklesial di tengan budaya individual? Melalui metode eksposisi dan studi literatur, ditemukan ada beberapa prinsip untuk mewujudkan kesatuan eklesial di tengah budaya individual, yakni satu dasar kesatuan, empat pilar kesatuan, tiga sifat kesatuan, dan dua sikap kesatuan.
The Study of Genetic Components in Okra [(Abelmoschus esculentus L.) Moench] Crop
Authors: Yadav Kalyan Singh , Singh Ajeet Pratap 
Published: June 2024

The present study of the genetic component in okra [Abelmoschus esculentus (L.) Moench]” crop was conducted during Kharif 2019 to ziad 2020 at the research farm of shri Durgaji post-graduate college Chaneshwar Azamgarh U.P. with ten genotypes Azad Bhindi1, Azad Bhindi 2, Azad Bhindi 3, KS 312, VRO5, KS 442, KS 439, BO2, Arka Abhay and Prabhani Kranti along with 11 characters viz days to flowering, height of plant, number of branches per plant /main shoot, number of first fruiting node height of first fruiting node number of nodes per plant, length of internodes, length of fruit, width of fruits, number of fruits per plant and fruit yield per plant. The genetic component of variance showed significant values for additive components for all the characters in both the generations except the height of the plant and the number of branches in F1 generation. The dominance components were also highly significant for all the characters in both generations except fruit yield per plant in F2 population. The degree of dominance showed dominance for all the characters in both generations. The ratio showed less than unity for all the characters in both generations. Analysis of variance for combining ability showed highly significant values both for gca and sca variances based on both generations. However, the magnitude of the GCA variance was more than the sca variance for all the characters in both F1 and F2 generations. Additive gene action was observed for all the characters in both generations.
Report on Phytophthora sp. Causing Corm Rot of Colocasia (Colocasia esculenta L.) from Prayagraj, Uttar Pradesh, India
Authors: Nirmala Divi Niharika , A. Lal Abhilasha , Simon Sobita 
Published: June 2024

Taro [(Colocasia esculenta L.) Schott] also known as old cocoyam or true cocoyam is a water-loving herbaceous plant. Taro is affected by major diseases and pests in different parts of the world but among them taro blight and corm rot caused by a fungus-like oomycete Phytophthora colocasiae Racib is most important disease. The infected corm samples were collected from markets in two districts of Andhra Pradesh and the experiment was carried out based on Koch’s postulates in the Department of Plant Pathology, SHUATS, Prayagraj during Rabi season (2022-23). Isolation was done from collected corm samples (infected corms) for identification of the pathogen. Based on the cultural and morphological characters under microscopic examination, the pathogen was identified as Phytophthora sp. which causes corm rot and leaf blight of Colocasia. The isolated pathogen was inoculated into the healthy corms of Colocasia. At the time of corm germination, the typical symptoms were observed like downy whitish growth on the surface of the corms and on the leaf surface as small grey to brown discoloured water-soaked spots which later enlarged, became dark brown and coalesced, ﬁnally destroyed entire leaf lamina. After the examination of the symptoms, reisolation was done and pathogenecity of the fungus was proved by Koch’s postulates. Perusal of the literature revealed that Phytophthora sp. causes post and pre harvest corm rot and leaf blight in colocasia and it seems to be the first report from Prayagraj, Uttar Pradesh.
Radiographic severity of ankylosing spondylitis is associated with polymorphism of the large multifunctional peptidase 2 gene in the Spondyloarthritis Research Consortium of Canada cohort
Authors: Haroon Nigil , Maksymowych Walter P. , Rahman Proton , Tsui Florence W. L. , O'Shea Finbar D. , Inman Robert D. 
Published: October 2011

AbstractObjectiveThere are limited data on genetic predictors of radiographic progression. The aim of this study was to examine polymorphisms in genes involved in antigen presentation and their effect on radiographic severity and progression.MethodsCaucasian patients with ankylosing spondylitis (AS) (diagnosed according to the modified New York criteria) from 2 Canadian centers were enrolled. Patients in the progression part of the study had at least 2 sets of radiographs obtained at a minimum gap of 1.5 years, with a modified Stoke Ankylosing Spondylitis Spine Score (mSASSS). Peripheral blood DNA was used for genotyping a panel of 13 coding‐region single‐nucleotide polymorphisms (SNPs) in ERAP1, LMP2, LMP7, TAP1, and TAP2. Linear regression analysis was performed to identify the predictors of the baseline mSASSS and logistic regression for predictors of progression. Progression was defined as an increase of 1 mSASSS unit per year.ResultsA total of 241 AS patients (81% males; 82% HLA–B27–positive) were enrolled from the 2 centers for analysis of the predictors of baseline radiographic severity. In univariate analyses, the baseline mSASSS was associated with sex, disease duration, and SNPs rs30187 (ERAP1) and rs17587 (LMP2). In multivariate analyses, duration of disease (B = 0.74; P = 1 × 10−11), sex (B = 12.1; P = 5 × 10−5), and the LMP2 SNP rs17587 (B = 6.2; P = 0.01) were significantly associated with the baseline mSASSS. In multivariate analyses of progression, only the baseline mSASSS was a significant predictor (B = 0.03; P = 0.003).ConclusionThis is the first study to demonstrate that LMP2 variants can affect radiographic severity in AS. The baseline mSASSS remains the strongest predictor of radiographic progression but explains only a fraction of the variability seen.
Metabolic stress–induced inflammation plays a major role in the development of osteoarthritis in mice
Authors: Gierman L. M. , van der Ham F. , Koudijs A. , Wielinga P. Y. , Kleemann R. , Kooistra T. , Stoop R. , Kloppenburg M. , van Osch G. J. V. M. , Stojanovic‐Susulic V. , Huizinga T. W. , Zuurmond A.‐M. 
Published: October 2011

AbstractObjectiveObesity is associated with systemic inflammation and is a risk factor for osteoarthritis (OA) development. We undertook this study to test the hypothesis that metabolic stress–induced inflammation, and not mechanical overload, is responsible for the development of high‐fat diet–induced OA in mice.MethodsHuman C‐reactive protein (CRP)–transgenic mice received a high‐fat diet without or with 0.005% (weight/weight) rosuvastatin or 0.018% (w/w) rosiglitazone, 2 different drugs with antiinflammatory properties. Mice fed chow were included as controls. After 42 weeks, mice were killed and histologic OA grading of the knees was performed. To monitor the overall inflammation state, systemic human CRP levels were determined.ResultsMale mice on a high‐fat diet had significantly higher OA grades than mice on chow and showed no correlation between OA severity and body weight. In male mice, high‐fat diet–induced OA was significantly inhibited by rosuvastatin or rosiglitazone to OA grades observed in control mice. Both treatments resulted in reduced human CRP levels. Furthermore, a positive correlation was found between the relative individual induction of human CRP evoked by a high‐fat diet on day 3 and OA grade at end point.ConclusionHigh‐fat diet–induced OA in mice is due to low‐grade inflammation and not to mechanical overload, since no relationship between body weight and OA grade was observed. Moreover, the OA process was inhibited to a great extent by treatment with 2 drugs with antiinflammatory properties. The inflammatory response to a metabolic high‐fat challenge may predict individual susceptibility to developing OA later in life. The use of statins or peroxisome proliferator–activated receptor γ agonists (e.g., rosiglitazone) could be a strategy for interfering with the progression of OA.
Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection
Authors: Caramés Beatriz , Taniguchi Noboru , Seino Daisuke , Blanco Francisco J. , D'Lima Darryl , Lotz Martin 
Published: October 2011

AbstractObjectiveMechanical injury induces cell death in cartilage and triggers a remodeling process that ultimately can manifest as osteoarthritis. Autophagy is a process for turnover of intracellular organelles and macromolecules that protects cells during stress responses. This study was undertaken to determine changes in and functions of autophagy following mechanical injury to cartilage.MethodsBovine and human cartilage explants were subjected to mechanical impact (40% strain for 500 msec). Cell viability, sulfated glycosaminoglycan (sGAG) release, and changes in the levels of the autophagy markers ULK1, beclin 1, and microtubule‐associated protein 1 light chain 3 (LC3) were evaluated. Cartilage explants were treated with the mammalian target of rapamycin complex 1 (mTORC‐1) inhibitor and the autophagy inducer rapamycin and tested for protective effects against mechanical injury. Explants were also treated with the cell death inducers nitric oxide and tumor necrosis factor α (TNFα) plus actinomycin D, and the proinflammatory cytokine interleukin‐1α (IL‐1α).ResultsMechanical injury induced cell death and loss of sGAG in a time‐dependent manner. This was associated with significantly decreased ULK1, beclin 1, and LC3 expression in the cartilage superficial zone (P < 0.05) 48 hours after injury. The levels of LC3‐II were increased 24 hours after injury but decreased at 48 and 96 hours. Rapamycin enhanced expression of autophagy regulators and prevented cell death and sGAG loss in mechanically injured explants. Rapamycin also protected against cell death induced by sodium nitroprusside and TNFα plus actinomycin D and prevented sGAG loss induced by IL‐1α.ConclusionOur findings indicate that mechanical injury leads to suppression of autophagy, predominantly in the superficial zone where most of the cell death occurs. Pharmacologic inhibition of mTORC‐1, at least in part by enhancement of autophagy, prevents cell and matrix damage, suggesting a novel approach for chondroprotection.
Organometallic Rotaxanes with a Triazole Group in the Axle Component and Their Behavior as Ligands of PtII Complexes
Authors: Yu Gilbert , Suzaki Yuji , Abe Tomoko , Osakada Kohtaro 
Published: October 2011

AbstractTwo ferrocenylmethyl ammonium salts were used as axle components of pseudorotaxanes with dibenzo[24]crown‐8. The pseudorotaxane with an alkyne terminal group in the axle component underwent a Cu‐catalyzed Huisgen coupling reaction (click reaction) with an alkyl azide to afford cationic [2]rotaxanes with a triazole group in the axle molecule. The rotaxane reacted with Ac2O to produce neutral rotaxanes with an amide group in the axle component. Both cationic and neutral rotaxanes were treated with K[PtCl3(CH2CH2)] to form the PtII‐containing rotaxanes.
Abnormal Thermal Expansion of Clathrate Hydrates Induced by Asymmetric Guest Molecules
Authors: Cha Minjun , Youn Yeobum , Kwon Minchul , Shin Kyuchul , Lee Seongsu , Lee Huen 
Published: October 2011

AbstractWe investigated for the first time the abnormal thermal expansion induced by an asymmetric guest structure using high‐resolution neutron powder diffraction. Three dihydrogen molecules (H2, D2, and HD) were tested to explore the guest dynamics and thermal behavior of hydrogen‐doped clathrate hydrates. We confirmed the restricted spatial distribution and doughnut‐like motion of the HD guest in the center of anisotropic sII‐S (sII‐S=small cages of structure II hydrates). However, we failed to observe a mass‐dependent relationship when comparing D2 with HD. The use of asymmetric guest molecules can significantly contribute to tuning the cage dimension and thus can improve the stable inclusion of small gaseous molecules in confined cages.
Schisandrin B enhances the glutathione redox cycling and protects against oxidant injury in different types of cultured cells
Authors: Lam Philip Y. , Leong Pou Kuan , Chen Na , Ko Kam Ming 
Published: October 2011

AbstractTert‐butylhydroperoxide (tBHP) challenge caused an initial depletion of cellular reduced glutathione (GSH), which was followed by a gradual restoration of cellular GSH in AML12, H9c2, and differentiated PC12 cells. The time‐dependent changes in cellular GSH induced by tBHP were monitored as a measure of GSH recovery capacity (GRC), of which glutathione reductase (GR)‐mediated glutathione redox cycling and γ‐glutamate cysteine ligase (GCL)‐mediated GSH synthesis were found to play an essential role. While glutathione redox cycling sustained the GSH level during the initial tBHP‐induced depletion, GSH synthesis restores the GSH level thereafter. The effects of (−)schisandrin B [(−)Sch B] and its analogs (Sch A and Sch C) on GRC were also examined in the cells. (−)Sch B and Sch C, but not Sch A, ameliorated the extent of tBHP‐induced GSH depletion, indicative of enhanced glutathione redox cycling. However, the degree of restoration of GSH post‐tBHP challenge was not affected or even decreased. Pretreatment with (−)Sch B and Sch C, but not Sch A, protected against oxidant injury in the cells. The (−)Sch B afforded cytoprotection was abolished by N,N′‐bis(chloroethyl)‐N‐nitrosourea pretreatment suggesting the enhancement of glutathione redox cycling is crucially involved in the cytoprotection afforded by (−)Sch B against oxidative stress‐induced cell injury.
A mechanistic model for enzymatic saccharification of cellulose using continuous distribution kinetics II: Cooperative enzyme action, solution kinetics, and product inhibition
Authors: Griggs Andrew J. , Stickel Jonathan J. , Lischeske James J. 
Published: October 2011

AbstractThe projected cost for the enzymatic hydrolysis of cellulosic biomass continues to be a barrier for the commercial production of liquid transportation fuels from renewable feedstocks. Predictive models for the kinetics of the enzymatic reactions will enable an improved understanding of current limitations, such as the slow‐down of the overall conversion rate, and may point the way for more efficient utilization of the enzymes in order to achieve higher conversion yields. A mechanistically based kinetic model for the enzymatic hydrolysis of cellulose was recently reported in Griggs et al. (2011) (Part I). In this article (Part II), the enzyme system is expanded to include solution‐phase kinetics, particularly cellobiose‐to‐glucose conversion by β‐glucosidase (βG), and novel adsorption and product inhibition schemes have been incorporated, based on current structural knowledge of the component enzymes. Model results show cases of cooperative and non‐cooperative hydrolysis for an enzyme system consisting of EGI and CBHI. The model is used to explore various potential rate‐limiting phenomena, such as substrate accessibility, product inhibition, sterically hindered enzyme adsorption, and the molecular weight of the cellulose substrate. Biotechnol. Bioeng. 2012; 109:676–685. © 2011 Wiley Periodicals, Inc.