bluuebunny/crossref_metadata_2025_split huggingface dataset:
IL-6 inhibition with clazakizumab in patients receiving maintenance dialysis: a randomized phase 2b trial
Authors: Chertow Glenn M. , Chang Anna Marie , Felker G. Michael , Heise Mark , Velkoska Elena , Fellström Bengt , Charytan David M. , Clementi Regina , Gibson C. Michael , Goodman Shaun G. , Jardine Meg , Levin Adeera , Lokhnygina Yuliya , Mears Jenny , Mehran Roxana , Stenvinkel Peter , Wang Angela Yee-Moon , Wheeler David C. , Zoccali Carmine , Ridker Paul M. , Mahaffey Kenneth W. , Tricoci Pierluigi , Wolf Myles 
Published: May 2024

AbstractInflammation mediated by interleukin-6 (IL-6) is strongly associated with cardiovascular risk. Here we evaluated clazakizumab, a monoclonal antibody targeting the IL-6 ligand, in a phase 2b dose-finding study. Adults with cardiovascular disease and/or diabetes receiving maintenance dialysis with high-sensitivity C-reactive protein (hs-CRP) ≥ 2 mg l−1 at baseline were randomized to receive clazakizumab (2.5 mg, 5 mg or 10 mg, n = 32 per dose group) or placebo (n = 31) every 4 weeks. The primary endpoint was the change from baseline in hs-CRP to week 12, expressed as the geometric mean ratio. Clazakizumab treatment signficantly reduced serum hs-CRP concentrations at week 12 by 86%, 90% and 92% relative to placebo in patients randomized to 2.5 mg, 5 mg or 10 mg clazakizumab, respectively (all P < 0.0001), meeting the primary outcome. With regard to secondary endpoints, clazakizumab treatment reduced serum fibrinogen, amyloid A, secretory phospholipase A2, and lipoprotein(a) concentrations, as well as increased mean serum albumin concentrations at 12 weeks, relative to placebo. The proportion of patients who achieved hs-CRP < 2.0 mg l−1 was 79%, 82% and 79% in the 2.5 mg, 5 mg and 10 mg clazakizumab groups, respectively, compared with 0% of placebo-treated patients. With regard to safety, no cases of sustained grade 3 or 4 thrombocytopenia or neutropenia were observed. Serious infections were seen with similar frequency in the placebo, clazakizumab 2.5 mg and clazakizumab 5 mg groups, but were numerically more frequent in the clazakizumab 10 mg group. The results of this trial indicate that in patients receiving maintenance dialysis, clazakizumab reduced inflammatory biomarkers associated with cardiovascular events. ClinicalTrials.gov registration: NCT05485961.
Examining the mediating role of muscle quantity in adolescents: associations with adiposity, cardiorespiratory fitness, muscular fitness, and cardiometabolic risk factors
Authors: Leite Neiva , Tadiotto Maiara C. , de Moraes Junior Frederico B. , de Menezes-Junior Francisco J. , Corazza Patricia R. P. , da Silva Larissa R. , Lopes Wendell A. , de Matos Oslei , Radominski Rosana B. , Coelho-e-Silva Manuel J. 
Published: May 2024

AbstractThe aim of this study was to evaluate the mediation role of muscle quantity in the relationship between physical fitness and cardiometabolic risk factors (CMRF) in adolescents. This cross-sectional study conducted with 120 adolescents of both sexes, aged between 10 and 17 years. Body mass, height, fat mass (FM), lean mass, blood pressure, high-density lipoprotein, low-density lipoprotein, triglycerides, glucose, insulin, cardiorespiratory fitness (CRF) and 1 repetition maximum strength (1-RM) with evaluation of the leg press 45° (RM-leg), bench press (RM-bench) and arm curl (RM-arm). Body mass index z-score, appendicular skeletal muscle mass, appendicular skeletal muscle mass index, lean mass index (LMI), muscle-to-fat ratio (MFR), age at peak height velocity, and CMRF z-score were calculated. The direct relation between FM and CMRF was mediated by the LMI (26%) and inverse relation between CRF and CMRF was mediated by the LMI (26%). For girls, the direct relation between FM and CMRF was mediated by the LMI (32%); the inverse relation between CRF, RM-leg, RM-arm and CMRF was mediated by the LMI (32%, 33%, and 32%, respective). For boys, the indirect effect was not significant, indicating that LMI is not a mediator in the relation between FM, CRF, 1-RM with CMRF. The direct relation between RM-leg and CMRF was mediated by the MRF (16%). This finding evidenced the importance of promoting a healthy lifestyle to improve physical fitness levels and the quantity of muscle mass in adolescents.
Constrained trajectory optimization and force control for UAVs with universal jamming grippers
Authors: Kremer Paul , Rahimi Nohooji Hamed , Voos Holger 
Published: May 2024

AbstractThis study presents a novel framework that integrates the universal jamming gripper (UG) with unmanned aerial vehicles (UAVs) to enable automated grasping with no human operator in the loop. Grounded in the principles of granular jamming, the UG exhibits remarkable adaptability and proficiency, navigating the complexities of soft aerial grasping with enhanced robustness and versatility. Central to this integration is a uniquely formulated constrained trajectory optimization using model predictive control, coupled with a robust force control strategy, increasing the level of automation and operational reliability in aerial grasping. This control structure, while simple, is a powerful tool for various applications, ranging from material handling to disaster response, and marks an advancement toward genuine autonomy in aerial manipulation tasks. The key contribution of this research is the combination of a UG with a suitable control strategy, that can be kept relatively straightforward thanks to the mechanical intelligence built into the UG. The algorithm is validated through numerical simulations and virtual experiments.
Cartilage tissue engineering using decellularized biomatrix hydrogel containing TGF-β-loaded alginate microspheres in mechanically loaded bioreactor
Authors: Bordbar Sima , Li Zhen , Lotfibakhshaiesh Nasrin , Ai Jafar , Tavassoli Amin , Beheshtizadeh Nima , Vainieri Letizia , Khanmohammadi Mehdi , Sayahpour Forough Azam , Baghaban Eslaminejad Mohamadreza , Azami Mahmoud , Grad Sibylle , Alini Mauro 
Published: May 2024

AbstractPhysiochemical tissue inducers and mechanical stimulation are both efficient variables in cartilage tissue fabrication and regeneration. In the presence of biomolecules, decellularized extracellular matrix (ECM) may trigger and enhance stem cell proliferation and differentiation. Here, we investigated the controlled release of transforming growth factor beta (TGF-β1) as an active mediator of mesenchymal stromal cells (MSCs) in a biocompatible scaffold and mechanical stimulation for cartilage tissue engineering. ECM-derived hydrogel with TGF-β1-loaded alginate-based microspheres (MSs) was created to promote human MSC chondrogenic development. Ex vivo explants and a complicated multiaxial loading bioreactor replicated the physiological conditions. Hydrogels with/without MSs and TGF-β1 were highly cytocompatible. MSCs in ECM-derived hydrogel containing TGF-β1/MSs showed comparable chondrogenic gene expression levels as those hydrogels with TGF-β1 added in culture media or those without TGF-β1. However, constructs with TGF-β1 directly added within the hydrogel had inferior properties under unloaded conditions. The ECM-derived hydrogel group including TGF-β1/MSs under loading circumstances formed better cartilage matrix in an ex vivo osteochondral defect than control settings. This study demonstrates that controlled local delivery of TGF-β1 using MSs and mechanical loading is essential for neocartilage formation by MSCs and that further optimization is needed to prevent MSC differentiation towards hypertrophy.
Microtopography effects on pedogenesis in the mudstone-derived soils of the hilly mountainous regions
Authors: Luo Banglin , Li Jiangwen , Tang Jiahong , Wei Chaofu , Zhong Shouqin 
Published: May 2024

AbstractTopography is a critical factor that determines the characteristics of regional soil formation. Small-scale topographic changes are referred to microtopographies. In hilly mountainous regions, the redistribution of water and soil materials caused by microtopography is the main factor affecting the spatial heterogeneity of soil and the utilization of land resources. In this study, the influence of microtopography on pedogenesis was investigated using soil samples formed from mudstones with lacustrine facies deposition in the middle of the Sichuan Basin. Soil profiles were sampled along the slopes at the summit, shoulder, backslope, footslope, and toeslope positions. The morphological, physicochemical, and geochemical attributes of profiles were analyzed. The results showed that from the summit to the toeslope, soil thickness increased significantly and profile configuration changed from A–C to A–B–C. The total contents of Ca and Na decreased at the summit, backslope, and footslope, while the total contents of Al, Fe and Mg showed an opposite trend. On the summit and shoulder of the hillslope, weathered materials were transported away by gravity and surface erosion, exposing new rocks. As a result, soil development in these areas was relatively weak. In flat areas such as the footslope and toeslope with sufficient water conditions, the addition of weathered components and the prolonged contact between water, soil, and sediment led to further chemical weathering, resulting in highly developed characteristics. Microtopography may influence physicochemical properties, chemical weathering, and redistribution of water and materials, causing variations in pedogenic characteristics at different slope positions.
Effects of expanded adverse childhood experiences including school bullying, childhood poverty, and natural disasters on mental health in adulthood
Authors: Sasaki Natsu , Watanabe Kazuhiro , Kanamori Yoshiaki , Tabuchi Takahiro , Fujiwara Takeo , Nishi Daisuke 
Published: May 2024

AbstractThe study aimed to examine the association of expanded adverse childhood experiences (ACEs) with psychological distress in adulthood. The data from nation-wide online cohort was used for analysis. Community dwelling adults in Japan were included. The ACEs was assessed by 15 items of ACE-J, including childhood poverty and school bullying. Severe psychological distress was determined as the score of Kessler 6 over 13. Multivariable logistic regression analysis was conducted, by using sample weighting. A total of 28,617 participants were analyzed. About 75% of Japanese people had one or more ACEs. The prevalence of those with ACEs over 4 was 14.7%. Those with ACEs over 4 showed adjusted odds ratio = 8.18 [95% CI 7.14–9.38] for severe psychological distress. The prevalence of childhood poverty was 29% for 50–64 year old participants and 40% of 65 or older participants. The impact of childhood poverty on psychological distress was less than other ACEs in these age cohorts. Bullying was experienced 21–27% in young generations, but 10% in 65 or older participants. However, the impact on psychological distress in adulthood was relatively high in all age groups. ACEs have impacted mental health for a long time. Future research and practice to reduce ACEs are encouraged.
Room corners and how they influence the memory of visual information arranged on walls
Authors: Garsoffky Bärbel , Schwan Stephan 
Published: May 2024

AbstractIn formal and informal learning settings corresponding information units are often arranged in the space around the viewer. For example, teachers pin task relevant information on classroom walls, or museum curators arrange exhibits in museum halls. Often learners and visitors are expected to see meaningful relationships between these information units. Theoretically, Gestalt Psychology has been examining the effects of connecting and separating elements in visual information displays, leading to the question of whether these findings also hold in three-dimensional environments. Does the mostly rectangular form of our rooms also either highlight or downplay relations between information dispersed across a room? Three experiments using virtual rooms showed that the matching pairs of pictures were memorized better if both pictures were arranged on the same wall instead of across two adjacent walls: that is, the presence of a room corner between matching pairs decreased memory (Experiments 1–3). Additionally, the findings showed that the participants’ orientation of their central field of view during learning influenced the effect of corners on memory. When initially looking around in rooms, participants most often oriented the center of their field of view toward the middle of a wall (Experiments 1 and 2); however, if they were restricted to orienting their field of view toward corners, the corner effect on memory vanished (Experiment 3). These findings suggest that room characteristics influence the exploratory behavior of viewers, thereby also affecting their memories of the presented information.
Association between retinopathy and risk of dementia in a general Japanese population: the Hisayama Study
Authors: Nakamura Shun , Ueda Emi , Ohara Tomoyuki , Hata Jun , Honda Takanori , Fujiwara Kohta , Furuta Yoshihiko , Shibata Mao , Hashimoto Sawako , Nakazawa Taro , Nakao Tomohiro , Kitazono Takanari , Sonoda Koh-Hei , Ninomiya Toshiharu 
Published: May 2024

AbstractWe investigated the association of retinopathy with the risk of dementia in a general older Japanese population. A total of 1709 population-based residents aged 60 years or older without dementia were followed prospectively for 10 years (2007–2017). They underwent color fundus photography in 2007. Retinopathy was graded according to the Modified Airlie House Classification. Main outcome was the Incidence of dementia. A Cox proportional hazards model was used to estimate the hazard ratios (HRs) and their 95% confidence intervals (CIs) for the risk of dementia by the presence of retinopathy. During the follow-up period, 374 participants developed all-cause dementia. The cumulative incidence of dementia was significantly higher in those with retinopathy than those without (p < 0.05). Individuals with retinopathy had significantly higher risk of developing dementia than those without after adjustment for potential confounding factors (HR 1.64, 95% CI 1.19–2.25). Regarding the components of retinopathy, the presence of microaneurysms was significantly associated with a higher multivariable-adjusted HR for incident dementia (HR 1.94, 95% CI 1.37–2.74). Our findings suggest that, in addition to systemic risk factors, retinal microvascular signs from fundus photography provide valuable information for estimating the risk of developing dementia.
Translation, cultural adaptation, and validation of Numerical Pain Rating Scale and Global Rating of Change in Tibetan musculoskeletal trauma patients
Authors: Liu Jinling , Chen Juncheng , Tian Leilei , Tang Chuan , Shuai Wenbin , Lin Fang , Luo Shilin , Xu Xinxin , An Jingjing 
Published: May 2024

AbstractTibetan-speaking patients seeking care in predominantly Mandarin-speaking healthcare settings frequently face communication barriers, leading to potential disparities and difficulties in accessing care. To address this issue, we translated, culturally adapted, and validated the Numerical Pain Rating Scale (NPRS) and the Global Rating of Change (GRoC) into Tibetan (NPRS-Tib and GRoC-Tib), aiming to facilitate cross-linguistic and cross-cultural interactions while examining potential challenges in the adaptation process. Using standard translation-backward translation methods, expert review, pilot testing, and validation through a cross-sectional study with a short-term longitudinal component, we engaged 100 Tibetan patients with musculoskeletal trauma for psychometric validation, including 37 women (aged 22–60 years, mean age 39.1 years). The NPRS-Tib and GRoC-Tib exhibited outstanding psychometric properties, with an Intraclass Correlation Coefficient (ICC) of 0.983 for NPRS-Tib indicating superb test–retest reliability, and expert review confirming good content validity for both instruments. A Spearman's correlation coefficient (Rho) of -0.261 (P = 0.0087) revealed a significant, albeit weak, correlation between changes in NPRS-Tib scores and GRoC-Tib scores. The adaptation process also presented notable challenges, including translation discrepancies from translators' diverse backgrounds and levels of expertise, ambiguity in scale options, and the lack of established tools for criterion validity assessment in Tibetan.
Tango and physiotherapy interventions in Parkinson’s disease: a pilot study on efficacy outcomes on motor and cognitive skills
Authors: Rabini Giuseppe , Meli Claudia , Prodomi Giulia , Speranza Chiara , Anzini Federica , Funghi Giulia , Pierotti Enrica , Saviola Francesca , Fumagalli Giorgio Giulio , Di Giacopo Raffaella , Malaguti Maria Chiara , Jovicich Jorge , Dodich Alessandra , Papagno Costanza , Turella Luca 
Published: May 2024

AbstractPharmacological treatments in Parkinson’s disease (PD), albeit effective in alleviating many motor symptoms, have limited effects in non-motor signatures as cognitive impairment, as well as in other aspects included postural instability. Consequently, complementary interventions are nowadays a prerogative of clinical practice managing PD symptomatology. In this pilot longitudinal study, we recruited twenty-four PD patients participating in one of two interventions: adapted Argentine Tango or group-based physiotherapy. Participants underwent a motor and neuropsychological evaluation before and after four months of activities, carried out twice a week. We found a general stabilization of motor and cognitive abilities, with significant improvements in several motor skills, mainly pertaining to static and dynamic balance, similarly in both groups. At cognitive level, we measured a significant improvement in both groups in the Action Naming task. Interestingly, only PD patients in the Tango group improved their performance in the test measuring facial emotion recognition. These findings highlight the crucial role that physical activities have in the stabilization and slowdown of disease’s progression in PD. They further highlight the beneficial effects of a group-based physical intervention, which, especially in the case of Tango, could lead to behavioral ameliorations in domains other than the motor, such as emotion recognition.
Chest ultrasound is better than CT in identifying septated effusion of patients with pleural disease
Authors: Yang Linhui , Wang Kaige , Li Weimin , Liu Dan 
Published: May 2024

AbstractSeptated pleural effusion is very common. The presence of septations in pleural effusion determines the local treatment strategy for such patients. Therefore, there is a pressing need for imaging techniques to assess the presence of septations. The objective of this research was to assess the diagnostic efficacy of computed tomography (CT) and chest ultrasound in identifying septated pleural effusion. We delineated the ultrasound and enhanced chest CT manifestations for diagnosing septated pleural effusions, and subsequently, we conducted a comparative analysis to assess the diagnostic efficacy of enhanced chest CT and ultrasound in identifying septated pleural effusions. Medical thoracoscopy served as the gold standard for confirming the diagnosis of septated pleural effusions. Ultrasound demonstrated a sensitivity of 82.6% (95% CI 73.3–89.7%) and a specificity of 100.0% (95% CI 98.1–NaN) for diagnosing septated pleural effusion. In comparison, enhanced chest CT exhibited a sensitivity of 59.8% (95% CI 49.0–69.9%) and a specificity of 87.0% (95% CI 81.5–91.4%). The positive predictive value for ultrasound was 100.0% (95% CI 95.3–100.0%), while for enhanced chest CT, it was 68.8% (95% CI 59.0–77.4%). Ultrasound yielded a negative predictive value of 92.3% (95% CI 87.5–NaN), and enhanced chest CT had a negative predictive value of 82.0% (95% CI 74.6–87.8%) in diagnosing septated pleural effusion. Thoracic ultrasound exhibits superior sensitivity and specificity compared to enhanced chest CT in diagnosing septated pleural effusions. Therefore, chest ultrasound is highly recommended as an adjunct for determining septated pleural effusion.
Comparison of dehydration systems in quality and chemical effects on sunflower seeds
Authors: Ortiz-Hernandez A. A. , Araiza-Esquivel M. A. , Delgadillo-Ruiz L. , Espinosa-Vega L. I. , Olvera-Olvera C. A. , Lopez-Martinez A. , Vega-Carrillo H. R. , Ortega-Sigala J. J. 
Published: May 2024

AbstractThe present work investigates the quality and the chemical effects of dehydration, using a novel dehydration system based on an electromagnetic induction and low pressures technique, comparing it with the thermo-solar drying system. High oleic sunflower seeds, which are an important oil seed crop, were used due to the fact that they have a special place in the food industry. The seed samples were exposed to electromagnetic induction and low pressures by 0.5 and 1 h, then several chemical characterizations were carried out, in the electrophoresis study, it was found that most proteins in the hull were degraded or denatured, some of them were lost during the time in the thermosolar dryer while in kernel keeps 94.9% of the concentration in control proteins. Otherwise, the electromagnetic induction dryer did not lose the most of proteins in the kernel keeping 99.1% in 0.5 h and 98.4% in 1 h, just degrading its concentration. Germination viability results did not show changes after 0.5 h in the electromagnetic fields, but they decreased in 1 h from 66 to 40% until the thermosolar method fell to 24% in 4 h, both analysis results change proportionally with the treatment time and moisture content and the amount of the oxygen.
Enhanced wound regeneration by PGS/PLA fiber dressing containing platelet-rich plasma: an in vitro study
Authors: Heydari Parisa , Zargar Kharazi Anousheh , Shariati Laleh 
Published: May 2024

AbstractNovel wound dressings with therapeutic effects are being continually designed to improve the wound healing process. In this study, the structural, chemical, physical, and biological properties of an electrospun poly glycerol sebacate/poly lactide acid/platelet-rich plasma (PGS/PLA-PRP) nanofibers were evaluated to determine its impacts on in vitro wound healing. Results revealed desirable cell viability in the Fibroblast (L929) and macrophage (RAW-264.7) cell lines as well as human umbilical vein endothelial cells (HUVEC). Cell migration was evident in the scratch assay (L929 cell line) so that it promoted scratch contraction to accelerate in vitro wound healing. Moreover, addition of PRP to the fiber structure led to enhanced collagen deposition (~ 2 times) in comparison with PGS/PLA scaffolds. While by addition PRP to PGS/PLA fibers not only decreased the expression levels of pro-inflammatory cytokines (IL-6 and TNF-α) in RAW-264.7 cells but also led to significantly increased levels of cytokine (IL-10) and the growth factor (TGF-β), which are related to the anti-inflammatory phase (M2 phenotype). Finally, PGS/PLA-PRP was found to induce a significant level of angiogenesis by forming branching points, loops, and tubes. Based on the results obtained, the PGS/PLA-PRP dressing developed might be a promising evolution in skin tissue engineering ensuring improved wound healing and tissue regeneration.