bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS KELAYAKAN USAHA IKAN LELE (Clarias sp) DI DESA MANGUNREJO KECAMATAN KEBONAGUNG
Authors: Wibowo Hendri , Rahmadani  , Endah Subekti  , Shofia Nur Awami  
Published: June 2024

Lele merupakan salah satu komoditas ikan yang dibudidayakan di Kabupaten Demak. Analisis kelayakan usaha sangatlah penting untuk keberlanjutan usaha budidaya pembesaran ikan lele. Penelitian ini bertujuan untuk mengetahui biaya produksi, penerimaan, pendapatan usaha, BEP, R/C usaha pembesaran ikan lele di Desa Mangunrejo Kecamatan Kebonagung Kabupaten Demak. Metode dasar penelitian yang digunakan dalam penelitian ini adalah metode deskriptif analisis. Metode pemilihan lokasi ditentukan menggunakan metode purposive sampling. Metode penentuan sampel responden menggunakan metode sensus. Metode analisis data yang digunakan yaitu perhitungan analisis biaya, penerimaan, pendapatan, analisis BEP unit, analisis BEP harga, R/C. Hasil penelitian menunjukkan usaha pembesaran ikan lele dalam satu periode (3 bulan) mengeluarkan biaya total sebesar Rp. 6.840.197 penerimaan sebesar Rp. 11.912.500 dan pendapatan sebesar Rp. 5.432.321. Nilai rata-rata BEP unit sebesar 324,001 Kg dan nilai rata-rata BEP harga sebesar Rp. 10.879/kg. Nilai R/C sebesar 1,84
Improving The Quality of Life and Resilience of The Elderly with Emotion Regulation Exercises
Authors: Rakhmawati Indriana , Nurhalimah Nurhalimah , Utami Tantri Widyarti 
Published: June 2024

The quality of life of the elderly will increase if they have psychological resilience to stress. Emotional regulation is the ability of older people to manage emotional responses in dealing with various stressors in life which will increase psychological resilience (the ability to overcome problems/stress) and quality of life. Objective. This research was conducted to find out whether emotional regulation interventions for the elderly have an effect on their quality of life and psychological resilience. This type of research is quantitative with a one group pretest-posttest design. The sample consisted of 36 elderly people who were selected using the purposive sampling method. The research process begins with administrative permits and questionnaire testing. Next, respondents were given emotional regulation training (4 meetings) and their resilience and quality of life were measured before and after the training. The instruments used to measure it are the Resilience Questionnaire (RSOA) and the Quality of Life Questionnaire (WHOQOL-Bref). Data were analyzed univariately using frequency and mean methods, bivariately using Spearmann rho correlation. The research results show that emotional regulation training can improve the resilience and quality of life of the elderly.
The shelf life of pork depends on its quality and microbial and non-microbial meat destructors
Authors: Stronskyi I. Y. , Simonov M. R. , Stronskyi Y. S. 
Published: June 2024

This work aimed to establish the maximum shelf life of pork of different quality classes depending on the action of non-microbial and microbial destructors. To achieve this goal, samples were taken from the longest back muscles of domestic and industrial pig carcasses. Depending on the results of organoleptic research, pork was divided into three quality classes: 1) NOR (close to optimal quality indicators), 2) PSE (pale, soft, exudative), and 3) DFD (dark, firm, dry). After that, each of the samples was divided into 1 equal parts and placed for storage in a refrigerator (t = 3 ± 1 °C). Each day, one part of the samples was used for laboratory research. The purpose of laboratory research was to establish the freshness of meat by determining the reaction to peroxidase, amino-ammonia nitrogen, reaction to ammonia with Nessler's reagent, and the content of short-chain fatty acids. In addition, the level of MAFAnM was determined. The results of laboratory studies showed that the fastest signs of spoilage were registered in pork, with signs of PSE obtained after the slaughter of pigs on small farms. The first signs of deterioration appeared already on the sixth day of storage. The second fastest spoilage rate (on the eighth day) was meat samples of the PSE quality class taken from pigs of industrial origin. At the same time, the highest increase in microbial contamination during storage was registered in meat samples of industrial origin with signs of DFD. We found that the microbial contamination of pork depends not only on the initial contamination at the production site but also on the quality class of the meat. On the 12th day of pork storage, only NOR-class meat samples of industrial origin remained fresh. Comparing meat samples of the same quality classes, asserting a shorter shelf life and a higher risk of meat products obtained due to domestic origin and backyard slaughter of pigs is possible. The main reason is a combination of factors, the main of which are the impossibility of observing proper hygienic conditions for animal slaughter, poor bleeding, unbalanced diet, and others.
Intervenções de Enfermagem de reabilitação ao paciente com lesão medular: Protocolo de Revisão de escopo
Authors: XAVIER AMANDA , Juarez de Souza Pereira  , Ricardo da Silva Monteiro  , Vanessa Vianna Cruz  , Hilmara Ferreira da Silva  , Wiliam César Alves Machado  
Published: June 2024

Introdução: A lesão da medula espinal é toda injúria às estruturas contidas no canal medular (medula, cone medular e cauda equina), podendo levar a alterações motoras, sensitivas, autonômicas e psicoafetivas e que causam repercussões físicas, psíquicas e sociais. Estudos apontam uma fragilidade na assistência à saúde do paciente com este tipo de lesão incapacitante, no contexto da Atenção Primária à Saúde e a necessidade de ações de educação permanente sobre o tema de reabilitação aos Enfermeiros. Apesar de ser a porta de entrada aos serviços de saúde e o primeiro nível de atenção ao usuário inserido em seu território, dentro de sua residência, esses usuários ainda vivenciam dificuldades como a desqualificação profissional para o atendimento integral ao paciente com lesão da medula espinal. O objetivo do estudo é desenvolver um protocolo de revisão de escopo que buscará identificar e sintetizar as evidências científicas disponíveis sobre as intervenções de enfermagem focadas na autonomia para atividades cotidianas de pessoas com lesão medular na Atenção Básica de Saúde.
Metodologia: Será utilizado o método proposto pelo JBI (Joanna Briggs Institute) e para sistematização das informações será utilizada a extensão PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) através do check list PRISMA ScR (Extension for Scoping Reviews), garantindo maior transparência e rigor metodológico. O presente protocolo será indexado na plataforma Open Science Framework.
Resultados: A busca dos textos será efetuada em nove bases de dados e na literatura cinzenta. Três revisores efetuarão a análise e seleção dos estudos, com auxílio do gerenciador de Diagrama de Fluxo PRISMA. Divergências serão dirimidas por um quarto revisor. Os dados serão extraídos conforme Ficha sistematizada para coleta dos dados referente à Revisão de Escopo e organizados no software Excel, e as conclusões dos estudos serão analisadas com auxílio de software.
Discussão: Os resultados serão apresentados de modo tabular e narrativo, visando alcançar objetivo e questão de revisão deste protocolo.
Conclusão: Espera-se que o estudo fortaleça a reabilitação nas práticas de Enfermagem na Atenção Primária à Saúde elucidando a necessidade de formação de Enfermeiros Especialistas em Enfermagem de Reabilitação (EEER) nas ações de Educação em Saúde.
RBD mutations at the residues K417, E484, N501 reduced immunoreactivity with antisera from vaccinated and COVID-19 recovered patients
Authors: Gupta Dablu Lal , Meher Jhasketan , Giri Anjan Kumar , Shukla Arvind Kumar , Mohapatra Eli , Ruikar Manisha M , Rao DN 
Published: June 2024

Introduction: It is unclear whether induced spike protein-specific antibodies due to infections with SARS-CoV-2 or to the prototypic Wuhan isolate-based vaccination can immune-react with the emerging variants of SARS-CoV-2.
Aim/objectives: The main objective of the study was to measure the immunoreactivity of induced antibodies postvaccination with Covishield™ (ChAdOx1 nCoV-19 coronavirus vaccines) or infections with SARS-CoV-2 by using selected peptides of the spike protein of wild type and variants of SARS-CoV-2.
Methodology: Thirty patients who had recovered from SARS-CoV-2 infections and 30 individuals vaccinated with both doses of Covishield™ were recruited for the study. Venous blood samples (5 mL) were collected at a single time point from patients within 3-4 weeks of recovery from SARS-CoV-2 infections or receiving both doses of Covishield™ vaccines. The serum levels of total immunoglobulin were measured in both study groups. A total of 12 peptides of 10 to 24 amino acids length spanning to the receptor-binding domain (RBD) of wild type of SARS-CoV-2 and their variants were synthesized. The serum levels of immune-reactive antibodies were measured using these peptides.
Results: The serum levels of total antibodies were found to be significantly (p<0.001) higher in the vaccinated individuals as compared to COVID-19 recovered patients. Our study reported that the mutations in the RBD at the residues K417, E484, and N501 have been associated with reduced immunoreactivity with anti-sera of vaccinated people and COVID-19 recovered patients.
Conclusion: The amino acid substitutions at the RBD of SARS-CoV-2 have been associated with a higher potential to escape the humoral immune response.
A importância do diagnóstico fetal precoce da hérnia diafragmática congênita e o prognóstico após a fetoscopia: Uma breve revisão de literatura
Authors: Monteiro Camila Rostang , Rodrigues Lívia , Santos Taylane Alves , Requeijo Márcio José Rosa 
Published: June 2024

Introdução: A hérnia diafragmática congênita (HDC) é uma patologia que se apresenta por uma alteração no diafragma que favorece a passagem de órgãos abdominais para o tórax, gerando dificuldade no desenvolvimento normal dos pulmões e, consequentemente, em muitos casos, a hipoplasia pulmonar e a hipertensão pulmonar como principal clínica. Em situações mais graves da clínica existe a possibilidade de realizar cirurgia intrauterina chamada de Oclusão Traqueal Endoscópica Fetal (FETO), a fim de auxiliar o desenvolvimento mais próximo do fisiológico dos pulmões e, assim, melhorar o prognóstico. Resultados e discussão: O melhor método de diagnóstico é a ultrassonografia durante o pré-natal. Esse acompanhamento é fundamental, para uma possível intervenção intrauterina, se necessário, como HDC. Objetivo: fazer uma abordagem sobre a HDC, levando em consideração a etiopatogenia da doença, o método de imagem mais adequado para diagnóstico, seu tratamento e possíveis complicações. Materiais e métodos: foi realizada uma revisão integrativa da literatura contendo os estudos mais recentes, dos anos de 2019 a 2024, relativos ao tema através da pesquisa nas bases de dados LILACS e MedLine, através do portal da BVS. Conclusão: o prognóstico da HDC, apresenta-se favorável, devido aos avanços dos métodos de imagem como ultrassom, tomografia e ressonância magnética, uma vez que a boa acurácia desses métodos, permitem o diagnóstico precoce, além de detectar anormalidades e o nível de gravidade. Ademais, fatores extrínsecos como a idade materna, é um fator prognóstico a ser avaliado, uma vez que possui grande impacto sobre a evolução e o prognóstico do caso.
Síndrome Stevens-Johnson e Necrólise Epidérmica Tóxica: Atualizações e Associações Farmacológicas
Authors: Raimundo Ana Paula de Araújo , Ribeiro Igor Oliveira , Brissac Julia Cambraia de Souza , Viana Júlia Herondina Madeira Siqueira , Fernandes Maria Eduarda Maia 
Published: June 2024

Introdução: O uso de medicamentos pode causar reações adversas, que incluem manifestações cutâneas em variados graus. Quando essas manifestações são graves, tem-se um espectro de condições que inclui as síndromes Stevens-Johnson (SSJ) e da necrólise epidérmica tóxica (NET), que são caracterizadas por uma reação exacerbada de hipersensibilidade com consequente apoptose de queratinócitos da pele. O objetivo do trabalho é elucidar a associação com fármacos e os aspectos clínicos e do manejo dessas condições. Metodologia: Trata-se de uma revisão integrativa acerca das associações farmacológicas com SSJ/NET. Utilizou-se dados das bases Biblioteca Virtual de Saúde (BVS), Scientific Eletronic Library of Medicine (SciELO) e National Library of Medicine (PubMed), a partir do cruzamento dos descritores “Síndrome de Stevens-Johnosn”, “antibióticos”, “anticonvulsivantes” e “efeitos adversos” para responder à questão formulada através da estratégia PICO. Resultados e Discussão: Dentre os fármacos associados ao desenvolvimento de SSJ/NET, destacam-se os antibióticos, anti-inflamatórios, antirretrovirais e anticonvulsivantes, principalmente as sulfonamidas e penicilinas do grupo de antimicrobianos e os antiepilépticos aromáticos. Ainda não se sabe ao certo se as manifestações diferem em relação ao medicamento causador. O diagnóstico geralmente é clínico, com auxílio da história do paciente. Ferramentas podem auxiliar a definição da conduta e da estimativa do prognóstico. O tratamento consiste na abordagem de suporte e de possíveis opções farmacológicas, como o uso de ciclosporinas. Conclusão: Uma vez que trata-se de uma condição rara e potencialmente fatal, mais estudos são necessários para definição de protocolos de conduta e tratamento mais eficazes para o atendimento dos pacientes com SSJ/NET.
Perspectiva anatômica e ética da caudectomia em cães
Authors: Mothé Gabriele Barros , Ferraz Vera Lúcia Teixeira , Dias Ana Luiza Souza , Duarte Gabriella da Silva , Brito Julia Barbosa de , Nascimento Raphael Espínola David do , Procopiak Reika Sato , Lameira Yasmin Xavier , Lima Renata Vieira Cerqueira , Mendes Junior Aguinaldo Francisco 
Published: June 2024

As vértebras caudais caninas compõem a cauda do cão, variando em número e tamanho entre as raças, e são fundamentais para o equilíbrio, comunicação e expressão emocional. A caudectomia é um procedimento cirúrgico de amputação dessas vértebras. No entanto, quando por motivos estéticos ou culturais, essa prática tem gerado debates intensos e controvérsias significativas, levantando questionamentos sobre a justificativa para sua continuação. Baseado nisso, este trabalho tem o objetivo de descrever a anatomia das vértebras dos cães e a caudectomia, destacando os danos potenciais que tal mutilação pode causar nesses animais, apoiando-se em uma revisão da literatura. Pesquisas indicam que a cauda é essencial não apenas para a comunicação canina, permitindo aos cães expressarem uma gama de emoções e intenções, mas também desempenha um papel crucial no equilíbrio, especialmente durante a corrida e ao realizar movimentos ágeis. A remoção da cauda pode, portanto, interferir significativamente no comportamento e na capacidade de expressão corporal dos cães, além de potencialmente causar dor, desconforto no período pós-operatório e levar a complicações sérias, como infecções e o desenvolvimento de neuroma de amputação, uma condição dolorosa que ocorre no coto da amputação. Atualmente, muitos países têm adotado leis e regulamentações que restringem ou proíbem a caudectomia em cães, exceto quando necessária por razões médicas. A crescente conscientização sobre o bem-estar animal tem levado a uma mudança de atitude em relação a essa prática, com mais tutores optando por manter a cauda natural de seus cães.
Comparative analysis through propensity score matching in thyroid cancer: unveiling the impact of multiple malignancies
Authors: Al-Ibraheem Akram , Abdlkadir Ahmed Saad , Al-Adhami Dhuha Ali , Lopci Egesta , Al-Omari Amal , Al-Masri Mahmoud , Yousef Yacoub , Al-Hajaj Nabeela , Mohamad Issa , Singer Susanne , Sykiotis Gerasimos P. 
Published: June 2024

BackgroundThe incidence of thyroid cancer is on the rise worldwide, with childhood exposure to radiation being the sole acknowledged catalyst for its emergence. Nonetheless, numerous other factors that may pose risks are awaiting thorough examination and validation. This retrospective study aims to explore the malignancies linked to thyroid cancer and contrast the survival rates of those afflicted with a solitary tumor versus those with multiple primary neoplasms (MPN).MethodsThis retrospective study examined data from King Hussein Cancer Center (KHCC), Jordan. Among 563 patients diagnosed with thyroid cancer, 30 patients had thyroid malignancy as part of MPN. For a 1:3 propensity score-matched analysis, 90 patients with only a primary thyroid malignancy were also enrolled.ResultsHematologic and breast malignancies were among the most frequent observed cancers alongside thyroid neoplasm. Patients who had MPN were diagnosed at older age, had higher body mass index and presented with higher thyroglobulin antibody levels (p &lt; 0.05 for each). Additionally, MPN patient displayed a stronger family history for cancers (p= 0.002). A median follow-up duration of 135 months unveiled that MPN patients faced a worse 5-year survival compared to their counterparts with a singular neoplasm (87% vs 100% respectively; p &lt; 0.01). However, no distinction emerged in the 5-year event-free survival between these two groups.ConclusionMPN correlates with a significantly altered survival outcome of thyroid cancer patients. The diagnosis of thyroid carcinoma at an older age, accompanied by elevated initial thyroglobulin antibody levels and a notable familial predisposition, may raise concerns about the potential occurrence of synchronous or metachronous tumors.
Preparation and electrochemical properties of Li6La3Zr0.7Ti0.3Ta0.5Sb0.5O12 high-entropy Li-garnet solid electrolyte
Authors: Ye Ruijie , Ting Yin-Ying , Dashjav Enkhtsetseg , Ma Qianli , Taminato Sou , Mori Daisuke , Imanishi Nobuyuki , Kowalski Piotr M. , Eikerling Michael H. , Kaghazchi Payam , Finsterbusch Martin , Guillon Olivier 
Published: June 2024

Garnet-type solid electrolytes stand out as promising Li-ion conductors for the next-generation batteries. It has been demonstrated that the inherent properties of garnets can be tailored by introducing various dopants into their crystal structures. Recently, there has been a growing interest in the concept of high entropy stabilization for materials design. In this study, we synthesized high-entropy garnets denoted as Li6La3Zr0.7Ti0.3Ta0.5Sb0.5O12 (LLZTTSO), wherein Ti, Sb, and Ta occupy the Zr site. The formation of the cubic garnet phase in LLZTTSO was confirmed through X-ray diffraction (XRD), and the resulting lattice parameter agreed with predictions made using computational methods. Despite the substantial porosity (relative density 80.6%) attributed to the low sintering temperature, LLZTTSO exhibits a bulk ionic conductivity of 0.099 mS cm−1 at 25°C, and a total ionic conductivity of 0.088 mS cm−1, accompanied by an activation energy of 0.497 eV. Furthermore, LLZTTSO demonstrates a critical current density of 0.275 mA cm−2 at 25°C, showcasing its potential even without any interfacial modification.
Routine antenatal molecular testing for α-thalassemia at a tertiary referral hospital in China: ten years of experience
Authors: Li Dongming , Liang Lifang , Meng Dahua , He Sheng 
Published: June 2024

ObjectiveThis study aimed to evaluate the efficacy of α-thalassemia gene testing as a part of an antenatal intervention program over a 10-year period.MethodsAll patients underwent α-thalassemia gene testing, which included the analysis of three types of deletions and mutations. Rare α-thalassemia gene testing was performed using Sanger sequencing, multiplex ligation-dependent probe amplification, and sequencing techniques. Prenatal diagnosis was performed in high-risk couples using chorionic villus sampling or amniocentesis.ResultsFrom 2010 to 2019, among the 91,852 patients examined, α-thalassemia mutations were identified in 41.78% of patients. The most frequent α0 gene mutation was--SEA, followed by--THAI. Two rare α0-thalassemia gene mutations at --32.8 and --230, were also observed. A total of 2,235 high-risk couples were identified, of which 562 were affected, including three with the--SEA/--THAI genotype and one with the--SEA/--230 genotype. Additionally, prenatal diagnosis revealed four cases of fetal anemia and/or mild edema, along with two cases of severe fetal edema. Chromosome and gene chip results were normal. Thalassemia gene testing showed an αCSα/αCSα genotype in four patients with anemia and/or mild edema, while two patients with severe fetal edema had one--SEA/αCSα genotype and one--SEA/--GX genotype. Using the cut-off points of 74.6 fL and 24.4 pg as criteria for identifying α0-thalassemia carriers and HbH disease, the detection rate of missed diagnoses in high-risk couples is consistent with national guidelines for standards, potentially saving 10,217,700 ¥.ConclusionRoutine molecular testing for α-thalassemia in high-risk prenatal populations effectively prevented severe α-thalassemia births. Despite the high cost, the cutoff points proposed by this study suggest that implementing screening using a new parameter has the potential to reduce current expenses.
Efficacy of steroid therapy in the acute stage of anti-NMDAR and anti-MOG antibody overlapping encephalitis: a case report and literature review
Authors: Kondo Hikari , Takeuchi Yuko , Niwa Junichi , Yoshida Kenji , Takemura Naoaki , Hosoyama Sachiko , Kaga Tomotsugu , Kaneko Kimihiko , Mabuchi Naoki 
Published: June 2024

BackgroundRecently, cases of overlapping encephalitis caused by anti-N-methyl-D-aspartate receptor (anti-NMDAR) and anti-myelin oligodendrocyte glycoprotein (MOG) antibodies have been reported, and their clinical characteristics are gradually becoming clear. Acute-phase treatment typically involves the use of steroids, and although some studies have suggested that steroids can be effective, the extent of their efficacy has not yet been fully explored.Case presentationWe present the case of a 25-year-old man with anti-NMDAR and anti-MOG antibody overlapping encephalitis who showed considerable improvement after steroid treatment. To gain a deeper understanding of the efficacy of steroids in managing this condition, we conducted a literature review of cases of anti-NMDAR and anti-MOG antibody double-positive encephalitis that were treated with steroids during the acute phase. Thirteen cases were analyzed, including a new case diagnosed at our hospital. All patients showed improvement after receiving steroid treatment in the acute phase. Ten patients did not have any sequelae, and nine of them showed a rapid or major response during the acute phase. In contrast, three patients experienced sequelae (mild cognitive decline, visual impairment, and memory impairment, respectively), with their response to steroids in the acute phase being slow or limited. Relapses occurred in five patients, in one patient during steroid tapering, and in another two patients after cessation of steroids.ConclusionSteroid therapy can be effective in the acute stage of anti-NMDAR and anti-MOG antibody overlapping encephalitis. A positive prognosis may be expected in patients who experience substantial improvement with steroid therapy during the acute phase.