bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the initial boundary values problem for a mixture of two Cosserat bodies with voids
Authors: Marin Marin , Öchsner Andreas , Vlase Sorin 
Published: June 2024

AbstractIn this study it is approached a linear model for the mixture of two Cosserat bodies having pores. It is formulated the mixed problem with initial and boundary data in this context. The main goal is to show that the coefficients that realize the coupling of the elastic effect with the one due to voids can vary, without the mixture being essentially affected. In a more precise formulation, this means that a small variation of the coefficients in the constitutive equations of the two continua causes only a small variation of the solutions of the corresponding mixed problems, that is, the continuous dependence of the solutions in relation to these coefficients is ensured. The considered mixture model is consistent because all estimates, specific to continuous dependence, are made based on rigorous mathematical relationships.
Is Europe prepared to live without emissions? A dynamic analysis of the energy transition in economic sectors
Authors: Lucindo Jesús , Feijóo Marisa , González-Álvarez María A. 
Published: June 2024

AbstractEurope has experienced the adverse effects of climate change due to the human footprint on a scale never seen before. The region's future appears challenging as it persistently adheres to conventional practices. To address this, social movements in Europe must advocate for policymakers to earnestly undertake the widely advocated energy transition within the existing socioeconomic model. A crucial aspect for governments is to comprehend the status along the trajectory of this transition. In this study, we investigate the intricate relationship between emissions, economy, and energy spanning the years 1990 to 2019 across 32 European countries. Our analysis differentiates among major polluting sectors, utilizing a dynamic model that accounts for potential structural breaks. Our findings confirm the presence of ruptures in the stability of the parameters, revealing three distinct periods marked by historical shocks. While the majority of European countries exhibit a decoupling between emissions and economic growth, a contrasting trend is observed between emissions and energy consumption. Notably, the energy supply and residential sectors emerge as the most problematic due to their high carbon intensity. However, the decoupling process remains distant in terms of energy, underscoring the imperative shift toward renewable energy sources over conventional fossil-based fuels. This study emphasizes the urgency of adopting sustainable practices to mitigate climate change and encourages a revaluation of current energy paradigms.
Structural characterization of the extracellular stalk material of the diatom Didymosphenia geminata
Authors: Dütsch Lara , Brendler Erica , Zuber Jan , Viehweger Christine , Ehrlich Hermann , Jesionowski Teofil , Vogt Carla 
Published: June 2024

AbstractThe study represents new bioanalytical characterization of mainly organic components of the poorly investigated extracellular polymeric substances (EPS) of the enigmatic diatom Didymosphenia geminata, an invasive, worldwide expanding species endangering diverse ecosystems. This microalga attaches its siliceous cells to rocky substrates using fibrous stalks, which are made of an EPS-based matrix stabilized by crystalline calcite. The EPS were analyzed using selected methods, including microscopic, spectroscopic, and spectrometric techniques. We identified diverse types of biomolecules. The presence of lipids, condensed aromatics, and heteroaromatic compounds in the EPS has been confirmed using high-resolution mass spectrometry (HR-MS). Additionally, both sulfur-containing functionalities and carboxylic acids were determined too using infrared (IR) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy. For the first time, lignin compounds have been detected as one of the components of the EPS of the D. geminata diatom, using HR-MS and fluorescence microscopy (FM) in combination with specific staining techniques. By increasing the understanding of the chemistry and structural features of the stalks, we aim to develop potential applications and methods for removing these stalks from affected regions in the future, or, alternatively, to use them as a large-scale source of sustainable biocomposite material.
Graphical abstract
Two Weeks of Continuous Opioid Treatment in an Adenine-Induced Mouse Model of Chronic Kidney Disease Exacerbates the Bone Inflammatory State and Increases Osteoclasts
Authors: Metzger Corinne E. , Grecco Gregory G. , Tak Landon Y. , Atwood Brady K. , Allen Matthew R. 
Published: June 2024

AbstractPatients with chronic kidney disease (CKD) report high pain levels, but reduced renal clearance eliminates many analgesic options; therefore, 30–50% of CKD patients have chronic opioid prescriptions. Opioid use in CKD is associated with higher fracture rates. Opioids may directly alter bone turnover directly through effects on bone cells and indirectly via increasing inflammation. We hypothesized that continuous opioid exposure would exacerbate the high bone turnover state of CKD and be associated with elevated measures of inflammation. Male C57Bl/6J mice after 8 weeks of adenine-induced CKD (AD) and non-AD controls (CON) had 14-day osmotic pumps (0.25-µL/hr release) containing either saline or 50-mg/mL oxycodone (OXY) surgically implanted in the subscapular region. After 2 weeks, all AD mice had elevated blood urea nitrogen, parathyroid hormone, and serum markers of bone turnover compared to controls with no effect of OXY. Immunohistochemical staining of the distal femur showed increased numbers of osteocytes positive for the mu opioid and for toll-like receptor 4 (TLR4) due to OXY. Osteocyte protein expression of tumor necrosis factor-α (TNF-α) and RANKL were higher due to both AD and OXY so that AD + OXY mice had the highest values. Trabecular osteoclast-covered surfaces were also significantly higher due to both AD and OXY, resulting in AD + OXY mice having 4.5-fold higher osteoclast-covered surfaces than untreated CON. These data demonstrate that opioids are associated with a pro-inflammatory state in osteocytes which increases the pro-resorptive state of CKD.
Hybrid Chin Advancement: Combining Fat and Sliced Cartilage Grafts for Chin Augmentation During Rhinoplasty
Authors: Selamioğlu Engin , Küçüker İsmail 
Published: June 2024

Abstract
Background
Facial balance significantly impacts aesthetics, particularly in the middle and lower thirds. Patients with chin retrusion often benefit from sagittal plane chin advancement in rhinoplasty, enhancing surgical outcomes and satisfaction.

Objectives
This article presents a method for analyzing chin deformities and discusses a hybrid treatment approach to harmonize facial features, complementing rhinoplasty.

Methods
The chin positions of patients treated by the senior author were assessed. A retrospective analysis included 49 patients with chin retrusion of 2.5–6 mm. Among them, 22 patients initially offered chin implants declined, leading to planned chin augmentation. Fat grafting was exclusively performed for 20 patients lacking sufficient cartilage. The "Hybrid Chin Advancement" technique involved supporting tissues beneath muscles with nasal septum cartilage and fat injections and tissues above muscles with fat injection alone.

Results
Pre- and postoperative Legan angle measurements and chin advancements were compared across three groups. While preoperative Legan angles were statistically similar, postoperative Legan angles and advancement changes were significantly higher in the implant group (p < 0.0001). Comparing hybrid chin advancement and fat grafting groups, postoperative Legan angles and advancement changes were significantly higher in the hybrid chin group (p < 0.0001).

Conclusions
Fat grafting suffices for mild advancements (~ 2 mm), while the hybrid chin method is effective for moderate advancements (~ 4 mm). For advancements exceeding 6 mm, implants or osseous genioplasty are optimal. Our study’s hybrid approach offers an easy, safe, and reliable method for achieving facial harmony in the lower two-thirds without compromising patient expectations.

Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Efficacy and safety of fostamatinib in refractory immune thrombocytopenia: a meta-analysis from randomized controlled trials
Authors: Tungjitviboonkun Songphol , Bumrungratanayos Naharuthai , Jitwimungsanon Jedsadakorn , Kheamakulvanich Thanat , Siramongkholkarn Smuch 
Published: June 2024

Abstract
Background
Immune thrombocytopenia (ITP) is an immune-mediated disease that results in low platelet counts. Despite appropriate treatment, many patients continue to experience refractory disease. Fostamatinib, an oral spleen tyrosine kinase (SYK) inhibitor, has emerged as a promising option for refractory ITP.

Objective
This meta-analysis aims to evaluate the efficacy and safety of fostamatinib compared to conventional therapy in adults aged ≥ 18 years with refractory ITP.

Materials and methods
Literature search was conducted in PubMed, Scopus, Embase, and clinicaltrials.gov databases from inception to March 31, 2024. Randomized controlled trials (RCTs) assessing the safety and efficacy of fostamatinib in adults with refractory ITP were included. Data extraction, risk of bias assessment, and statistical analysis were performed following PRISMA guideline.

Results
A total of 495 articles were screened, with three RCTs meeting the inclusion criteria. Fostamatinib therapy demonstrated superior efficacy in achieving stable platelet response by week 24 (ORR 0.80; 95%CI 0.72–0.88), platelet count ≥ 50,000/µL at weeks 12 (ORR 0.80; 95%CI 0.72–0.90) and week 24 (ORR 0.82; 95%CI 0.72–0.90). Additionally, fostamatinib improves platelet counts in subjects with a baseline count of < 15,000/µL. The Number Needed to Treat (NNT) was calculated as 10. Adverse effects include diarrhea (RR 2.32; 95%CI 1.11–4.84), hypertension (RR 2.33; 95%CI 1.00-5.43), and abnormal liver function tests (RR 4.18; 95% CI 1.00-17.48). Interestingly, the occurrences of nausea (RR 1.77; 95% CI 0.33–9.67) and rash (RR 2.28; 95% CI 0.50-10.29) did not achieve statistical significance.

Conclusion
This meta-analysis provides robust evidence supporting the efficacy of fostamatinib in improving platelet counts and achieving therapeutic goals in adults with refractory ITP. However, fostamatinib’s safety profile warrants consideration due to higher rates of diarrhea, hypertension, and abnormal liver function tests.
Dorsal wrist ganglion: clinical and imaging correlation in symptomatic population based on high-field MRI
Authors: Ferreira Branco David , Botti Paul , Bouvet Cindy , Abs Bilal , Buzzi Marcello , Beaulieu Jean Yves , Poletti Pierre-Alexandre , Bouredoucen Hicham , Boudabbous Sana 
Published: June 2024

Abstract
Objectives
To determine prevalence in the symptomatic population of dorsal mucoid cysts centered on dorsal capsuloscapholunate septum (DCSS) using high-field magnetic resonance imaging (MRI) for anatomoclinical and epidemiological correlations.

Materials and methods
This single-center retrospective study analyzed all 3-Tesla MRIs consecutively performed for painful wrists in 295 patients. Two blinded readers performed measurements. The protocol included T1 spin echo and 3D proton density sequences with fat saturation. Inter-observer reliability was assessed using kappa and intra-class correlation coefficients for cyst detection and volumetry, respectively. Disagreements concerning cyst detection were resolved by a consensus reading. Cyst size, relationship to extrinsic and scapholunate ligaments (SL), continuity of SL, minimum distance to the posterior interosseous nerve (PIN), cyst communication with joint, and anatomical classifications of cysts were analyzed. Correlation tests were performed to assess associations.

Results
Two-hundred ninety-five patients (mean age 39.6 +/− 15.6 (standard deviation), 161 males) were evaluated for detection of dorsal wrist cysts identified in 150/295. In this subgroup, the mean age was 38.7 years (15–75), the sex ratio of 0.6 (59% women), and the median volume cyst of 8.7 mm3 (0.52–2555). Cyst detection, volume, and major axis measurements showed very high agreement between observers, respectively, 0.89, 0.96, and 0.91. 42 patients had dorsal SL pain. A weak negative correlation was found between distance to PIN and dorsal SL pain (r = −0.2415; p < 0.05) and a weak positive correlation between Guérini’s classification and dorsal SL pain (r = 0.2466; p < 0.05).

Conclusion
High-field MRI is the modality of choice for the detection, anatomical, and volumetric assessment of dorsal cysts. Preoperative assessment will be aided by the proposed revised anatomical classification.

Clinical relevance statement
High-field MRI is the modality of choice for the anatomical study of dorsal ganglion cysts. It allows the radiologist to accurately describe the anatomical relationships, size, and visibility of the pedicle, essential information for the surgeon’s preoperative assessment.

Key Points

Dorsal mucoid wrist ganglion is a condition for which prevalence remains to be determined.

High-field MRI is a reproducible imaging modality for the detection and assessment of dorsal wrist cysts.

High-field MRI has a key role in the preoperative management of dorsal mucoid cysts.
Sulphate reduction and carbonate precipitation in a high-energy algal rim framework
Authors: Leplastrier Aero , Rintoul Max , Opdyke Bradley , Nand Vikashni , Branson Oscar , Eggins Stephen M. , Ellwood Michael J. 
Published: June 2024

AbstractAlgal ridges are protective features for coral reefs that form through the accretion and encrustation of reef rubble and debris by crustose coralline algae (CCA) and processes of diagenetic cementation. Carbonate precipitation and dissolution dynamics on and within algal ridge frameworks are poorly understood. We studied the surface and subsurface geochemistry of the algal ridge framework at One Tree Island, Australia. Measurable quantities of hydrogen sulphide were detected in most porewater samples collected from bores, indicating a largely anoxic ridge framework. Total alkalinity (TA) and pH measurements indicate that the precipitation of carbonate minerals within the interior of the ridge framework occurs under largely anoxic conditions and is likely to be driven by TA changes associated with sulphate-reducing bacteria. Modelling of porewater hydrogen sulphide concentrations in combination with TA and dissolved inorganic carbon (DIC) indicates anoxic respiration processes produce alkalinity within the algal ridge framework. However, significantly more TA is removed via the precipitation of mineral carbonate, resulting in porewater TA concentrations falling below the open seawater values. The precipitation of mineral carbonate also lowers interstitial water pH, such that pH changes are not solely from organic carbon diagenesis. The simultaneous precipitation and dissolution of carbonate minerals within the algal ridge framework are key to forming and cementing algal ridges, which are important physical protective features for coral reefs.
Vertebrate centromere architecture: from chromatin threads to functional structures
Authors: Andrade Ruiz Lorena , Kops Geert J. P. L. , Sacristan Carlos 
Published: June 2024

AbstractCentromeres are chromatin structures specialized in sister chromatid cohesion, kinetochore assembly, and microtubule attachment during chromosome segregation. The regional centromere of vertebrates consists of long regions of highly repetitive sequences occupied by the Histone H3 variant CENP-A, and which are flanked by pericentromeres. The three-dimensional organization of centromeric chromatin is paramount for its functionality and its ability to withstand spindle forces. Alongside CENP-A, key contributors to the folding of this structure include components of the Constitutive Centromere-Associated Network (CCAN), the protein CENP-B, and condensin and cohesin complexes. Despite its importance, the intricate architecture of the regional centromere of vertebrates remains largely unknown. Recent advancements in long-read sequencing, super-resolution and cryo-electron microscopy, and chromosome conformation capture techniques have significantly improved our understanding of this structure at various levels, from the linear arrangement of centromeric sequences and their epigenetic landscape to their higher-order compaction. In this review, we discuss the latest insights on centromere organization and place them in the context of recent findings describing a bipartite higher-order organization of the centromere.
Dentition patterns and molecular diversity of Mastophorus muris (Gmelin, 1790) (Nematoda: Spiruroidea) support a host-associated subdivision
Authors: Jost Jenny , Hirzmann Jörg , Ďureje Ľudovít , Maaz Denny , Martin Peer , Stach Thomas , Heitlinger Emanuel , Jarquín-Díaz Víctor Hugo 
Published: June 2024

AbstractMastophorus muris (Gmelin, 1790) is a globally distributed parasitic nematode of broad range mammals. The taxonomy within the genus Mastophorus and the cryptic diversity among the genus are controversial among taxonomists. This study provides a detailed morphological description of M. muris from Mus musculus combined with a molecular phylogenetic approach. Moreover, descriptions and molecular data of M. muris from non-Mus rodents and wildcats complement our findings and together provide new insights into their taxonomy. The analysis of M. muris was based on light microscopy and scanning electron microscopy. The morphological description focused on the dentition pattern of the two trilobed pseudolabia. Additionally, we described the position of the vulva, arrangement of caudal pairs of papillae, spicules and measured specimens from both sexes and the eggs. For the molecular phylogenetic approach, we amplified the small subunit ribosomal RNA gene and the internal transcribed spacer, and the cytochrome c oxidase subunit 1. Mastophorus morphotypes based on dentition patterns and phylogenetic clustering indicate a subdivision of the genus in agreement with their host. We recognize two groups without a change to formal taxonomy: One group including those specimens infecting Mus musculus, and the second group including organisms infecting non-Mus rodents. Our genetic and morphological data shed light into the cryptic diversity within the genus Mastopohorus. We identified two host-associated groups of M. muris. The described morphotypes and genotypes of M. muris allow a consistent distinction between host-associated parasites.
Morbidity and mortality following hiatal hernia repair in geriatric patients: a multicenter research network study
Authors: Kumar Sunjay S. , Rama Martina , Koeneman Scott , Tannouri Sami , Tatarian Talar , Palazzo Francesco 
Published: June 2024

AbstractBackgroundHiatal hernia is a common surgical pathology. Such hernias can be found incidentally and patients may opt for an initial nonoperative approach though many will pursue surgery after symptom progression. Data on the effects of age on the outcomes of hiatal hernia repair may help inform this decision-making process.MethodsThe TriNetX database was queried for all adult patients undergoing hiatal hernia repair from 2000 to 2023. Patients were divided into elective and emergent cohorts on the basis of diagnosis codes indicating obstruction or gangrene. Patients aged 80–89 were compared against those aged 65–79 in unadjusted analysis. Logistic regression models controlling for additional health history covariates were created to calculate odds ratios for primary outcomes.ResultsThere were 2310 octogenarians and 15,295 seniors who underwent elective hiatal hernia repair, and 406 octogenarians and 1462 seniors who underwent emergent repair during the study period. The vast majority of patients in both groups underwent minimally invasive operations. In the elective cohort, octogenarians had higher rates of mortality, malnutrition, sepsis, respiratory failure, pneumonia, DVT, blood transfusion, and discharge to nursing facility. In the emergent cohort, octogenarians had higher rates of mortality, malnutrition, sepsis, and respiratory failure. The odds ratios for mortality in the elective and emergent cohorts were 3.9 (95% CI 3.1–5.0) and 3.5 (95% CI 2.1–5.6), respectively.ConclusionOctogenarians are at a meaningfully increased risk for mortality and morbidity after both elective and emergent hiatal hernia repair compared to senior-aged patients. Greater consideration should be given to surgical repair prior to the 8th decade of life.
2D Representations of 3D Point Clouds Via the Stereographic Projection with Encryption Applications
Authors: Annaby M. H. , Mahmoud M. E. , Abdusalam H. A. , Ayad H. A. , Rushdi M. A. 
Published: June 2024

AbstractUsing the topological equivalence between the Riemann sphere$$\mathbb {S}$$Sand the extended complex plane$$\overline{\mathbb {C}} = \mathbb {C} \cup \{\infty \}$$C¯=C∪{∞}, where$$\mathbb {C}$$Cis the field of complex numbers, we establish 2D-bijective representations of 3D point clouds. Points of 3D point clouds are mapped into the Riemann sphere$$\mathbb {S}$$S, and a stereographic projection is implemented to map the points into the complex plane$$\mathbb {C}$$C. The way the 3D objects are mapped into$$\mathbb {S}$$Smay be varied for various applications. To prove the accuracy and efficiency of the proposed 2D representation of 3D objects, we apply this correspondence to 3D point cloud encryption. We utilize chaotic permutations, chaotic circuits, and Latin cubes in addition to the stereographic projection representation to construct our scheme. The permutation steps using chaotic maps and Latin cubes are carried out on the object data points in both$$\mathbb {S}$$Sand$$\overline{\mathbb {C}}$$C¯, while the chaotic circuits are applied to 2D projections of the 3D objects. To the best of our knowledge, no earlier work employed stereographic projections for 3D object encryption. Experimental simulations of this method show high encryption strength and strong confusion and diffusion properties based on quantitative and statistical measures.
Comparative study on muscle function in two different streptozotocin-induced diabetic models
Authors: Aisyah Rahmawati , Kamesawa Mion , Horii Mayu , Watanabe Daiki , Yoshida Yuki , Miyata Kenshu , Kumrungsee Thanutchaporn , Wada Masanobu , Yanaka Noriyuki 
Published: June 2024

Abstract
Aims
Streptozotocin (STZ) is widely used to study diabetic complications. Owing to the nonspecific cytotoxicity of high-dose STZ, alternative models using moderate-dose or a combination of low-dose STZ and a high-fat diet have been established. This study aimed to investigate the effects of these models on muscle function.

Methods
The muscle function of two STZ models using moderate-dose STZ (100 mg/kg, twice) and a combination of low-dose STZ and high-fat diet (50 mg/kg for 5 consecutive days + 45% high-fat diet) were examined using in vivo electrical stimulation. Biochemical and gene expression analysis were conducted on the skeletal muscles of the models immediately after the stimulation.

Results
The contractile force did not differ significantly between the models compared to respective controls. However, the moderate-dose STZ model showed more severe fatigue and blunted exercise-induced glycogen degradation possibly thorough a downregulation of oxidative phosphorylation- and vasculature development-related genes expression.

Conclusions
Moderate-dose STZ model is suitable for fatigability assessment in diabetes and careful understanding on the molecular signatures of each model is necessary to guide the selection of suitable models to study diabetic myopathy.