bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-effectiveness analysis of increasing drug therapy coverage for patients with coronary artery disease in combination with atrial fibrillation and heart failure
Authors: Ignatieva V. I. , Kontsevaya A. V. , Lukyanov M. M. , Klyashtorny V. G. , Drapkina O. M. 
Published: May 2024

Aim. To make a cost-effectiveness analysis of increasing the prescription rate of combination therapy with beta-blockers (BBs), angiotensin-converting enzyme inhibitors or angiotensin receptor blockers (ACEIs/ARBs), statins and oral anticoagulants (OACs) in patients with coronary artery disease (CAD) in combination with atrial fibrillation (AF) and heart failure (HF).Material and methods. Based on the analysis of 6 medical registers, the proportion of patients with CAD in combination with AF and HF among all patients with CAD, and the prescription rate of BBs, ACEIs/ ARBs, OACs and statins, was assessed. Mortality and hospitalization rates were also determined in patients receiving only part of therapy or without it. In multivariate statistical models, the reduction in the risk of adverse events was calculated when all 4 drug groups were prescribed. Costs were calculated based on government procurement data and current compulsory health insurance rates. The obtained estimates were used to build a Markov model.Results. According to the modeling results, the number of patients with CAD in combination with AF and HF in the Russian Federation is 1,16-1,27 million people. When prescribing from 0 to 3 drug groups out of 4 required, the mortality rate was 115, and the hospitalization rate was 246 per 1000 patient-years. In the group of patients receiving all 4 groups of drugs, there was significant hazard ratio for death and hospitalization was 0,434 and 0,765, respectively. When modeling the prescription of drugs from all 4 groups in 1000 patients currently receiving only 0-3 groups of drugs, there was a reduction in the expected number of deaths by 52,3% (153 lives saved) and an expected number of hospitalizations by 16,0% (99 prevented hospitalizations) over 3 years. Additional costs per 1 life saved amounted to 515,3 RUB thousand.Conclusion. Patients with a combination of CAD, HF and AF are one of the groups with the highest risk of death and hospitalization for CVD. Modeling has shown that increasing coverage of this group of patients with appropriate therapy, including BBs, ACEIs/ARBs, statins and OACs, is a clinically and economically feasible solution.
Phytosanitary products from agriculture associated with the development of bladder cancer among farm owners and farm workers: a systematic review
Authors: Belcaid N. , Dassar I. , Abdellaoui A. , Taleb M. 
Published: May 2024

Context. Increased bladder cancer prevalence among farm owners and farm workers has been linked to high use of phytosanitary agents in agricultural activities. These results suggested that exposure to phytosanitary products and the risk of bladder cancer may be related.Objective. Examining the connection between phytosanitary products and the risk of bladder cancer was the goal of the current systematic review and meta-analysis.Methods. Through PubMed, Scopus, Science Direct, and Web of Science, a thorough literature searches of works updated to 2022 was carried out. The estimates of odd ratio (OR) with 95 % confidence intervals for the highest versus the lowest exposure to pesticide were compiled using fixed- or random-effect models. A prevalence meta-analysis was performed using Cochrane Revman Software.Results. According to the pooled OR estimates, exposure to phytosanitary conditions was linked to a higher risk of bladder cancer (OR 1.59; 95 % confidence interval 0.51–5.02). Results in the cohort and case–control groups both showed a connection.Conclusion. According to the majority of studies, exposure to phytosanitary agents and the risk of bladder cancer are directly correlated. According to certain research, smoking may increase the risk of bladder cancer.
Aromatic L-amino acid decarboxylase deficiency – disease under the masks of cerebral palsy and epilepsy
Authors: Chebanenko N. V. 
Published: May 2024

Aromatic L‑amino acid decarboxylase (AADC) deficiency is a rare autosomal recessive neurometabolic disorder that leads to a severe combined deficiency of serotonin, dopamine, norepinephrine and epinephrine. The disease manifests in early childhood with nonspecific symptoms such as hypotension, movement disorders (oculogyric crisis, dystonia, hypokinesia), developmental delay and vegetative symptoms.Currently, diagnostic criteria for this disease have been determined, as well as possible options for correcting the patient’s condition. However, often, the no specificity of AADC deficiency symptoms leads to a significant delay in diagnosis or even misdiagnosis in patients with AADC deficiency. Identification of patients with AADC deficiency will improve their quality of life due to possible syndromic treatment, facilitate their care and prolong life. In the absence of a correct diagnosis, children with AADC deficiency may be observed for a long time with diagnoses such as cerebral palsy or epilepsy and receive therapy that has no therapeutic effect or may lead to a worsening of the symptoms of the underlying disease.
EBF3-associated hypotonia, ataxia and delayed development syndrome – the mask cerebral palsy (case report)
Authors: Afandieva L. Z. , Gaynetdinova D. D. , I D. V. 
Published: May 2024

Pathogenetic nucleotide variants at many genetic loci can cause conditions like cerebral palsy. Establishing the etiologic diagnosis is clinically important for optimal disease management and treatment.The presented family case demonstrates a clinical polymorphism associated with variants in the EBF3 gene that impaired transcription regulation. The described variant c.703C>T (p.His235Tyr) in the EBF3 leads to severe motor and intellectual disability mimicking cerebral palsy.Timely detection of monogenic diseases hiding under the mask of cerebral palsy will help to establish a timely diagnosis and conduct medical and genetic counseling to prevent recurrent cases in the family.
Fabrication of SBA-15-supported nanoscale Co3O4 and its use in the catalytic hydrogenation of cinnamaldehyde
Authors: Bepari Ruhul Amin , Das Birinchi Kumar 
Published: May 2024

The full-text of the article will be published in the English version of the journal "Catalysis in Industry" No. 4, 2024.Nanoscale Co3O4 has successfully been supported onto the mesoporous SBA-15 following two methods viz. direct deposition (DD) and isonicotinate ligand assisted (INL) route. The later method (INL) involves the formation of cobalt isonicotinate tetrahydrate complex inside mesopore volumes of SBA-15 and subsequent calcination of the cobalt complex loaded SBA-15 composite. The present method is found to be advantageous in reducing the formation of oxide particles outside mesopores. The synthesized materials are investigated by various physical tools such as XRD, SEM, TEM and H2–TPR in combination with N2 adsorption–desorption study. As a promoter, little amount of gold is also deposited in SBA-15 supported Co3O4 samples and all these materials are explored as catalysts in the hydrogenation of cinnamaldehyde. The composite material that is synthesized via DD method has shown promising results in the hydrogenation reaction giving 50 % CAL conversion with 66 % selectivity for HCAL at 170 °C under the hydrogen pressure of 20 bars.
The formation of a crop of fodder and semi-sugar beet under irrigation in conditions of global warming
Authors: Shevchenko V. A. , Solovyov A. M. , Popova N. P. , Kulchev A. Yu. 
Published: May 2024

Relevanse.To reduce the negative impact of drought on the production process of agrocenoses of field crops, the entire complex of agrotechnical and reclamation measures should be used to ensure increased drought resistance of crops in the structure of crop rotations for various purposes.The purposeof our research was to study the dynamics of the growth of the raw mass of root crops and the collection of dry matter by the periods of growth and development of fodder and semi-sugar beet at different moisture levels of the root layer of the soil.Material and methodology.The research was carried out in a specially built arid zone, which is a 3x20 m plot, isolated from soil moisture to a depth of 1.5 m by a clay castle along the periphery and a dense reinforced polyethylene film between the variants. The arid area was divided into four plots, each with an area of 15 m2 (3x5 m), in which a different level of moisture supply was maintained throughout the growing season. The variety of fodder beet Eckendorf yellow and semi–sugar beet – Semi-sugar pink variety were used as the object of research.Results.It has been established that at all values of humidity, the maximum accumulation of the raw mass of root crops in both varieties was noted in the second period of growth and development of plants, which lasts an average of 60 days and lasts from the beginning of closing of crops in rows to the beginning of opening in row spacing. Among the studied irrigation regimes, the option should be recognized as optimal, where during the growing season the relative humidity of the root layer at a depth of 1 m is maintained at the level of 70-75% of the WPV. With such moisture, the yield of root crops for fodder beet is 855 centners/ha, for semi-sugar beet – 679 centners/ha, and the collection of dry matter – 120.54 and 156.33 centners/ha, respectively. With a further increase in humidity to 75-80% of the FPV, the increase in yield and collection of dry matter per 1 ha of crops for both beet varieties is within the statistical error of the experiment, however, the cost of irrigation water for the formation of 1 q of dry matter increases by an average of 2.2 times, which negatively affects the cost of grown products. It has been proven that the optimal regime of soil moisture is provided by the irrigation scheme according to the periods of growth and development of plants 1 3 1; irrigation rate – 400 m3/ha, irrigation rate – 2000 m3/ha.
Assessment of breeding material european small radish for salad lines
Authors: Stepanov V. A. 
Published: May 2024

Relevance. In connection with the development of industrial hydroponics in the country, the need arose to create targeted varieties and hybrids of F1 small radish for salad lines, which have special requirements. They should be productive, early ripening and shade-tolerant, with a rounded root shape and a small compact rosette of leaves, resistant to premature stem formation (stem formation). Root vegetables should be juicy, dense, without voids and bitterness, as well as with a high content of ascorbic acid and other biologically active substances and low accumulation of pollutants.Methodology. The material for the study was selection samples of small radishes created in the laboratory of selection and seed production of table root crops of the Federal State Budgetary Institution " Federal Scientific Vegetable Center". The assessment of promising breeding material was carried out in the seedling department of the Richel greenhouse and in the production conditions of Moskovsky LLC according to the methods adopted by the Federal Scientific Center.Results. Based on the assessment results, promising leveled material was identified, adapted to the conditions of salad lines, both in terms of a set of characteristics and in individual areas of selection: No. 81 with high yield and marketability, having large red root crops of a round-oval shape and a small leaf rosette, No. 83 – with large roots, small leaf rosette and resistance to flowering, No. 80 is a genetic source of high resistance to flowering (3.6%) combined with marketability and a small leaf rosette. Genetic sources of high dry matter content were identified – the Dutch hybrid F1 Gloritet, monosaccharides – sample No. 83, ascorbic acid – No. 76, 81, 82, 84, high content of vitamin "C" and monosaccharides in root vegetables – No. 76. In the production conditions of Moskovsky LLC, three promising samples small radishes stood out with a yield of more than 2200 g per 1 m2 and a marketability of 93.9-96.8%, distinguished by large rounded red root crops, a small rosette of leaves and a thin axial root.
Efficiency of the main application of fertilizers and top dressing of eggplant under drip irrigation on ordinary chernozems of the Rostov region
Authors: Borisov V. A. , Menshikh A. M. , Sosnov V. S. 
Published: May 2024

Relevance. Fertigation is the application of fertilizers, in which nutrients are dissolved in water for irrigation. This method is relevant when growing eggplant in the Rostov region, allowing effective use of fertilizers, since nutrients enter directly into the roots of plants, which eliminates their loss to evaporation or weathering. During fertigation, there is no need to carry out separate procedures for fertilization and irrigation, operations are combined into one, which reduces time and costs. The Rostov region is characterized by variable climatic conditions, including drought and strong winds. Fertigation ensures uniform and constant nutrition of plants, allowing them to better adapt to weather conditions, and can help increase yields by optimizing plant growth and development conditions.Material and methodology. In the conditions of the Rostov region, on ordinary heavy loamy chernozems, studies were conducted on the cultivation of eggplant on different backgrounds of the main application of mineral fertilizers in calculated doses before planting and using root fertilizing with complex fertilizers with trace elements with irrigation (fertigation), as well as leaf fertilizing with organomineral fertilizer Arksoil during the growing season.Results. It was revealed that mineral fertilizers and top dressing accelerated the growth and development of plants, and in the best case, the increase in indicators was 2 times higher compared with the control, while the height of the main stem, the number of lateral shoots and the number of ovaries on the plant, as well as the average weight of the fruit, significantly increased, which ensured an increase in plant productivity. The combined use of basic fertilizer and complex soluble fertilizers in the drip irrigation system has significantly increased plant productivity and increased yields to 77.82 t/ha. The application of high doses of fertilizers in combination with fertigation with water-soluble fertilizers did not actually affect the quality of fruits. The content of dry matter and nitrates remained at an optimal level.
Fighting slugs and snails on potato plantings
Authors: Vasilieva S. V. , Zeyruk V. N. , Derevyagina M. K. , Belov G. L. , Kolesova E. A. 
Published: May 2024

Relevanse. The article presents information about actively spreading potential pests of agricultural crops in the Central region of the Russian Federation – slugs and snails – invertebrates belonging to the genus of gastropods. The harmfulness of these pests is manifested in a decrease in the size of the crop, a decrease in its quality, loss of marketability and fruit keeping. The most seriously affected in this regard are the planting of cabbage, lettuce, peas, turnips, potatoes and cucumbers. Snails and slugs can serve as a source of infectious diseases, various fungal spores, bacteria and parasitic helminths are often carried with the mucus produced by their bodies, which often pose a threat to the health of people and pets.Methods. Visual surveys were carried out to determine the number of pests in the field and in the adjacent territory in the conditions of the Moscow region (Lyubertsy city district). The studies were conducted in accordance with officially approved methods. Data on the species composition of pests are analyzed. The possibility of active harmful activity and potential threat of gastropods in a changing climate and their adaptation in the conditions of the Central region of the Russian Federation is considered.Results. According to the results of the conducted research, it was found that in vegetable gardens and private farms, grape snail and arable slug are most often found, in potato plantings – field (arable slug). Recommendations on slug and snail control in the private sector and farms are given.
The feasibility and effectiveness of using biological products on onions (<i>Allium cepa</i> L.) in an annual crop
Authors: Irkov I. I. , Uspenskaya O. N. , Bernaz N. I. 
Published: May 2024

Relevanse. Rhizosphere associative bacteria, multiplying on root secretions, provide the plant with the entire complex of necessary nutrients from the soil and help increase productivity.The purpose of the research was to identify the feasibility and effectiveness of using bacterial preparations, optimizing the rates and timing of their application when cultivating onions as an annual crop on alluvial meadow soils of the Non-Chernozem Zone.Materials and Methods. Field experiments were carried out on the experimental field of VNIIO on an area of 1000 m2 in 2021-2023. We used drugs provided by the Federal State Budgetary Scientific Institution "All-Russian Research Institute of Agricultural Microbiology" (St. Petersburg): BisolbiPlant BIS88 (Bacillus pumilis strain); N40 – Experimental strain (Paenibacillus xylanexedens) – bacillary nitrogen fixer; V514 – Experimental strain (Bacillus megaterium) – bacillary stimulator of mobilization of soil phosphates and phosphorus from mineral fertilizers. The following tasks were solved by year: 2021 – Integrated use of biological products at application rates, l/ha: 0.0; 10.0; 20.0; 40.0; 2022 – Application of biological products in the following options: Control, Control + BIS88 (1+1) l/ha, Control + BIS88 (1+1) l/ha + N40 (1+1) l/ha + V514 (1+1) l/ha; 2023 – Options: BIS88 (0.5+0.5) l/ha + N40 (0.5+0.5) l/ha + V514 (0.5+0.5) l/ha at different base levels spring fertilization: N160P160K160; N110P110K110; N60P60K60.Results. It is not advisable to apply the studied bacterial preparations at a total rate of more than 10.0 l/ha during the cultivation of onions due to plant disease with bacteriosis. The use of the BisolbiPlant drug at a rate of (0.5+0.5) l/ha helps to increase the yield of onions with harvest quality comparable to the control. Biological products applied in combination with irrigation water during the growing season: BIS88 (0.5+0.5) l/ha; N40 (0.5+0.5) l/ha; V514 (0.5+0.5) l/ha, provide an increase in yield (13.4%) with harvest quality comparable to the control in the case of a low (N60P60K60) level of basic spring fertilizer application with subsequent fertilizing during the growing season Ca40N30 + N40K40 + N40K40. At the rates of the main spring application of fertilizers N110P110K110 and N160P160K160, complex application of preparations does not ensure an increase in the yield and its quality.
Decolonizing a Wretched Healthcare System: The African Public Health Practitioner Case
Authors: Whembolua Guy-Lucien , Tshiswaka Daudet Ilunga 
Published: May 2024

Introduction
Over the past two years, public health practitioners in African countries have worked actively to combat the Coronavirus Disease 2019 (COVID-19) pandemic with relatively low fatality rates. This pandemic has forced healthcare professionals to re-think and redesign the healthcare system within their own country.

Methods
Using the Afrocentric PEN-3 framework and a letter style, the purpose of this commentary was to describe the positive, existential, and negative socio-cultural values associated with African healthcare systems. The commentary also highlights socio-cultural factors affecting public trust in African healthcare systems and their health agencies and how systematically decolonizing them may decrease foreign reliance and empower efficient locally based solutions.

Results
We, as African public health practitioners, make three key points in this commentary. First, African public health practitioners have developed resilience within under-resourced healthcare systems. Secondly, oral tradition in African societies and its byproduct (social media) is the means through which people connect and share what they know about any topics (COVID-19). Thirdly, African leaders have particularly contributed to the high level of distrust in their countries’ healthcare systems in favor of the healthcare systems of industrialized countries.

Conclusion
This commentary concludes with implications for encouraging African public health practitioners to cultivate the resilience that has led to contributing to the wellness of millions of Africans during this COVID-19 pandemic.
UPAYA INOVATIF DOSEN MENUJU HARMONI ILMU: MEMBANGUN IKLIM INTEGRASI ILMU DI FAKULTAS ILMU AGAMA ISLAM UNIVERSITAS ISLAM INDONESIA
Authors: Rif'ah Naila , M. Husnaini  
Published: May 2024

Di era globalisasi tantangan kehidupan manusia menjadi semakin kompleks. Kerja sama antar disiplin ilmu menjadi suatu keniscayaan bagi manusia untuk mempertahankan peradabanya. Oleh karena itu, dibutuhkan upaya pengembangan pola hubungan antara sains dan agama menuju ke arah integrasi. Dewasa ini, perguruan tinggi islam di Indonesia terutama Universitas Islam Negeri mulai mengembangkan konsep integrasi ilmu yang sesuai dengan ruh yang dimiliki masing-masing universitas. Universitas Islam Indonesia (UII) yang merupakan pergurun tinggi berbasis islam tertua dan besar di Indonesia juga mengembangkan paradigma integrasi ilmunya sendiri. Keberhasilan pengembangan paradigma integrasi ilmu pada suatu universitas akan melibatkan semua pihak yang ada di dalamnya. Tidak hanya stakeholders dan guru besar, peran dosen juga tidak kalah penting. Penelitian ini bertujuan untuk mengetahui upaya inovatif dosen dalam membangun iklim integrasi ilmu di Fakultas Ilmu Agama Islam UII. Metode yang digunakan dalam penelitian adalah dengan pendekatan kualitatif, teknik pengumpulan data menggunakan teknik observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan bahwa model pengembangan integrasi keilmuan di UII adalah paradigma wasathiyah di mana perspektif tentang hubungan ilmu dan agama adalah bersifat objektif dan proporsional. Adapun upaya yang dilakukan dosen mencakup 3 bidang yaitu bidang pendidikan dan pengajaran, penelitian dan pengembangan, serta pengabdian pada masyarakat.
Kata kunci : Upaya Inovatif, Dosen, Harmoni Ilmu, Integrasi Ilmu, Fakultas Ilmu Agama Islam UII
Atipikus beszélők beszédének megítélése kisiskolás korban
Authors: Bodnár Noémi 
Published: May 2024

A gyermekek nyelvi attitűdjének kutatása fontos adalékokkal szolgálhat az anyanyelvi nevelés, a nyelvi érzékenyítés témaköréhez. A gyermekek mindennapjaik során találkozhatnak olyan beszélőkkel, akiknek a beszéde valamilyen szempontból eltér a megszokottól. Jelen tanulmány kisiskolás korú gyermekek három atipikus beszédmód: az idegen akcentus, az r-l paralália, valamint a hallássérültekre jellemző beszédmód iránti attitűdjének a feltérképezésére koncentrál. A 30 első osztályos gyermekkel végzett mérés eredményei szerint a gyermekek képesek észrevenni a különböző beszédmódok közötti eltéréseket, és bizonyos változatokat negatívabban ítélnek meg. Az attitűdök nem kizárólag az adott beszédmódra, hanem az adott beszédmóddal rendelkező beszélőre is kiterjednek. A megfelelő nyelvi érzékenyítés hozzájárulhat a lingvicizmus kialakulásának a megelőzéséhez, valamint a nyelvi attitűdök formálásához.