bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barreras invisibles y mujeres directivas en España
Authors: Castaño Cecilia , Martín Juan , Vázquez Susana , Martínez José Luis 
Published: December 2010

Resumen.Los autores dan cuenta de una investigación sobre los perfiles personales y académicos de hombres y mujeres con responsabilidades directivas en empresas españolas, su situación profesional y su postura respecto a la igualdad de género. Las directivas españolas son más jóvenes que sus homólogos masculinos, pero los alcanzan o superan en cualificación profesional y tienen menos hijos que ellos. Sin embargo, siguen luchando contra las barreras que impiden el aprovechamiento pleno del enorme capital humano femenino. A pesar de las medidas tomadas, más de nueve de cada diez puestos directivos siguen ocupados por hombres.
La transición de Tailandia en las esferas laboral y sanitaria
Authors: Kelly Matthew , Strazdins Lyndall , Dellora Tarie , Khamman Suwanee , Seubsman Sam‐ang , Sleigh Adrian C. 
Published: December 2010

Resumen.La economía de Tailandia ha cambiado rápidamente de la agricultura a la industria manufacturera y el sector de los servicios, pero el ordenamiento del mercado laboral y la representación de los trabajadores son mucho menos consistentes que en los países desarrollados, donde hubo una transición más lenta y gradual hace ya décadas. Los autores estudian el robustecimiento de las políticas y la legislación tailandesas en el ámbito de la seguridad y la salud en el trabajo, que obedece a las normas internacionales y a la nueva Constitución democrática. Por último, identifican los principales retos pendientes, entre ellos el cumplimiento de la ley y una medición mejor de los efectos del trabajo en la salud física y mental.
The Cardiovascular Effects of GLP‐1 Receptor Agonists
Authors: Okerson Theodore , Chilton Robert J. 
Published: December 2010

SUMMARYGlucagon‐like peptide‐1 receptor (GLP‐1R) agonists have been shown to regulate blood glucose concentrations by mechanisms including enhanced insulin synthesis/secretion, suppressed glucagon secretion, slowed gastric emptying, and enhanced satiety. GLP‐1 receptors have also been identified in the heart, kidneys, and blood vessels, leading to the hypothesis that GLP‐1R agonists may affect cardiovascular function or cardiovascular disease (CVD). The aim of this literature review was to assemble and assess preclinical and clinical data of potential medical importance regarding the cardiovascular effects of GLP‐1R agonists. Preclinical studies with the GLP‐1R agonists GLP‐1, exenatide, or liraglutide provided evidence that GLP‐1R stimulation favorably affects endothelial function, sodium excretion, recovery from ischemic injury, and myocardial function in animals. Similar observations have been made in exploratory studies on GLP‐1 infusion in normal subjects and patients with type 2 diabetes. Post hoc analyses of phase III studies of patients with type 2 diabetes treated with exenatide(bid or qw) or liraglutide(qd) showed that these GLP‐1R agonists reduced blood pressure, an effect largely independent of weight loss, and that liraglutide slightly increased heart rate. Preliminary data also indicated that GLP‐1R agonists reduced markers of CVD risk such as C‐reactive protein and plasminogen activator inhibitor‐1. Ongoing studies are examining the effects of administering GLP‐1R agonists to patients at risk of CVD, postangioplasty patients, post‐CABG patients, and patients with heart failure. Additional studies should provide meaningful data to determine whether GLP‐1R agonists provide unique treatment benefits to patients at risk for or with established CVD.
Modeling and
Simulation of Wave Propagation Based on Atomistic Field
Theory
Authors: Wang Xianqiao , Lee James
D. , Deng Qian 
Published: December 2010

Abstract
Motivated by the need for a more efficient simulation of material behavior at both larger length scale and longer time scale than direct molecular dynamics simulation, an atomistic field theory (AFT) for modeling and simulation of multiphase material systems has been developed. Atomistic formulation of the multiscale field theory and its corresponding finite element implementation are briefly introduced. By virtue of finite element analysis of classical continuum mechanics, we show the existing phenomena of spurious wave reflections at the interfaces between regions with different mesh sizes. AFT is employed to investigate the wave propagation in magnesium oxide from the atomistic region to the continuum region without any special numerical treatment. Unlike some other atomistic/continuum computational methods, AFT has demonstrated the capability to display both acoustic and optic types of wave motion. Numerical results show that AFT has the capability to significantly reduce the wave reflections at the interface. This work provides a more fundamental understanding of wave reflections at the atomistic/continuum interface.
CANDU Reactor Space-Time Kinetic Model for Load Following Studies
Authors: Xia Lingzhi , Jiang Jin 
Published: December 2010

Abstract
This paper presents the development of a three-dimensional space-time neutronic kinetic model of a Canadian deuterium uranium (CANDU) reactor using a modal method. In this method, the reactor space-time neutron flux is synthesized by a time-weighted series of precalculated neutron flux modes. The modes are eigenfunctions of the governing neutron diffusion equation during reference steady-state operation. The xenon effect has also been considered. The reactor model is then implemented within a simulation platform of a CANDU6 reactor regulating system in MATLAB/SIMULINK. A nondimensionalized SIMULINK representation of the reactor kinetic model is established. The behavior of the reactor during load following transients has been simulated using the developed reactor-modeling module. The simulation results prove the efficiency of the model. A three-dimensional neutron flux distribution during transients is represented.
Porphyromonas gingivalis
Cysteine Proteinase Inhibition by κ-Casein Peptides
Authors: Toh Elena C. Y. , Dashper Stuart G. , Huq N. Laila , Attard Troy J. , O'Brien-Simpson Neil M. , Chen Yu-Yen , Cross Keith J. , Stanton David P. , Paolini Rita A. , Reynolds Eric C. 
Published: December 2010

ABSTRACT

Porphyromonas gingivalis
is a major pathogen associated with chronic periodontitis, an inflammatory disease of the supporting tissues of the teeth. The Arg-specific (RgpA/B) and Lys-specific (Kgp) cysteine proteinases of
P. gingivalis
are major virulence factors for the bacterium. In this study κ-casein(109-137) was identified in a chymosin digest of casein as an inhibiting peptide of the
P. gingivalis
proteinases. The peptide was synthesized and shown to inhibit proteolytic activity associated with
P. gingivalis
whole cells, purified RgpA-Kgp proteinase-adhesin complexes, and purified RgpB proteinase. The peptide κ-casein(109-137) exhibited synergism with Zn(II) against both Arg- and Lys-specific proteinases. The active region for inhibition was identified as κ-casein(117-137) using synthetic peptides. Kinetic studies revealed that κ-casein(109-137) inhibits in an uncompetitive manner. A molecular model based on the uncompetitive action and its synergistic ability with Zn(II) was developed to explain the mechanism of inhibition. Preincubation of
P. gingivalis
with κ-casein(109-137) significantly reduced lesion development in a murine model of infection.
Characterization of the Novel CMT Enzyme TEM-154
Authors: Robin Frédéric , Delmas Julien , Machado Elisabete , Bouchon Bernadette , Peixe Luísa , Bonnet Richard 
Published: December 2010

ABSTRACT
TEM-154, identified in Portugal in 2004, associated the substitutions observed in the extended-spectrum β-lactamase (ESBL) TEM-12 and in the inhibitor-resistant penicillinase (IRT) TEM-33. This enzyme exhibited hydrolytic activity against ceftazidime and a low level of resistance to clavulanic acid. Surprisingly, the substitution Met69Leu enhanced the catalytic efficiency of oxyimino β-lactams conferred by the substitution Arg164Ser. Its discovery confirms the dissemination of the complex mutant group of TEM enzymes in European countries.
Republished: Which antibody and which cancer in which paraneoplastic syndromes?
Authors: Gozzard Paul , Maddison Paul 
Published: December 2010

ABSTRACT
Paraneoplastic neurological syndromes can be associated with the presence of onconeural antibodies. These antibodies are the result of an immune response against a tumour that is ectopically expressing a neuronal antigen. The ‘classical’ onconeural antibodies (anti-Hu, Yo, Ma2, CRMP-5, amphiphysin and Ri) are directed against intracellular antigens and are strongly associated with underlying malignancy. By contrast, onconeural antibodies directed against cell surface antigens (eg, anti-NMDA, VGKC, AChR) have a weaker tumour association. This article gives a practical overview of the tumour associations, and the neurological associations, of the onconeural antibodies. There is also guidance on how to investigate occult malignancy in antibody positive cases.
Republished paper: The quest to eliminate intrathecal vincristine errors: a 40-year journey
Authors: Noble Douglas J , Donaldson Liam J 
Published: December 2010

ABSTRACT

Background
Intrathecal administration of vincristine is a rare event but catastrophic for the patient, family and clinical team involved. Analysis of this source of harm shows it to be a classic systems error which has proved intractable for nearly 40 years. Failure to learn from history, communicate safety solutions nationally and internationally, create safety agencies which effectively and reliably prevent adverse events, conduct investigations and enquiries which fully reveals how to mitigate system error, develop robust physical design solutions to prevent harm to patients, make effective solutions universal and preparing for the unexpected are all major challenges.

Conclusions
The elimination of rare yet catastrophic errors like this remains one of the tests of whether we can make healthcare safer. In this paper, we discuss why effective learning has been so slow and illustrate lessons for other fields of patient safety.
Ascospore germination patterns revealed ascomycetous biotrophic mycoparasite specificity to Fusarium hosts
Authors: Goh Yit Kheng , Vujanovic Vladimir 
Published: December 2010

Sphaerodes mycoparasitica is an ascomycetous mycoparasitic taxon commonly found growing and sporulating on Fusarium pathogens in Canada. Ascospores of S. mycoparasitica failed to germinate under different standard laboratory conditions (sterile distilled water, water agar, and commercially available media), even after heat- and cold-shock treatments. In contrast, spore germination was obtained on commercial potato dextrose agar medium amended with Fusarium filtrates. Significant improvement in the percentage of spore germination was obtained for the spores suspended in Fusarium filtrates. Fusarium avenaceum and Fusarium oxysporum filtrates induced the highest germination, whereas Fusarium sporotrichioides and Fusarium proliferatum triggered lower germination frequency. Filtrates of beneficial fungal inoculants, including Trichoderma harzianum (RootShield®), Penicillium bilaii (JumpStart®), and Chaetomium globosum , had no impact on germination. Ascospore suspensions showed a double-polar germination pattern in F. avenaceum filtrate and single-polar germination when challenged with F. oxysporum filtrate. Sphaerodes mycoparasitica grown on F. oxysporum maintained the same spore germination patterns when transferred on F. avenaceum for three subsequent offspring generations, indicating a stable genome-regulated expression. Preliminary phylogenetic analyses based on large subunit rDNA showed the evolution of a group of mycoparasitic Sphaerodes species from nonmycoparasitic ancestors, but no clear evidence of coevolution or cospeciation between known Sphaerodes and their Fusarium hosts.
A NOVEL APPROACH TO DNA COPY NUMBER DATA SEGMENTATION
Authors: WANG SILING , WANG YUHANG , XIE YANG , XIAO GUANGHUA 
Published: December 2010

DNA copy number (DCN) is the number of copies of DNA at a region of a genome. The alterations of DCN are highly associated with the development of different tumors. Recently, microarray technologies are being employed to detect DCN changes at many loci at the same time in tumor samples. The resulting DCN data are often very noisy, and the tumor sample is often contaminated by normal cells. The goal of computational analysis of array-based DCN data is to infer the underlying DCNs from raw DCN data. Previous methods for this task do not model the tumor/normal cell mixture ratio explicitly and they cannot output segments with DCN annotations. We developed a novel model-based method using the minimum description length (MDL) principle for DCN data segmentation. Our new method can output underlying DCN for each chromosomal segment, and at the same time, infer the underlying tumor proportion in the test samples. Empirical results show that our method achieves better accuracies on average as compared to three previous methods, namely Circular Binary Segmentation, Hidden Markov Model and Ultrasome.
A NEW EXAMPLE FOR MINIMALITY OF MONOIDS
Authors: Ateş Firat , Karpuz Eylem G. , Güngör A. Dilek , Çevik A. Sinan 
Published: December 2010

By considering the split extension of a free abelian monoid having finite rank by a finite monogenic monoid, the main purposes of this paper are to present examples of efficient monoids and, also, minimal but inefficient monoids. Although results presented in this paper seem as in the branch of pure mathematics, they are actually related to applications of Combinatorial and Geometric Group-Semigroup Theory, especially computer science, network systems, cryptography and physics etc., which will not be handled here.
THE UNIQUE EQUIVALENCE CLASS OF CHROMATIC RECTANGLE FREE 3-COLORINGS OF A 10 × 10 CHESSBOARD
Authors: Waters L. K. 
Published: December 2010

Consider an M × N chess board with each space colored one of K colors. A chromatic rectangle is a rectangular collection of spaces with all four corner spaces colored the same. An M × N : K NCR board is an M × N board for which there exists a K coloring with no chromatic rectangles. If every K coloring includes a chromatic rectangle, then that board is called an M × N : K CR board. The classification as NCR versus CR has been settled for K ∈ {1, 2, 3} and all positive integers N and M. Note that transposition, or interchanging rows, columns, or colors, will preserve the existence of chromatic rectangles within a coloring. With this in mind, two colorings of a board are called equivalent if one can be produced from the other by such manipulations. This paper establishes that all 10 × 10 : 3 NCR colorings are equivalent. The results stem from characterizations of NCR colorings. These characterizations permit devising and implementing a backtracking algorithm for finding NCR colorings within a significantly restricted search space. In the 10 × 10 : 3 case, the restricted search space is small enough to complete an exhaustive search in about an hour. Several NCR colorings for larger boards, with K > 3, are also included.
Evaluation of Random Delay Insertion against DPA on FPGAs
Authors: Lu Yingxi , O’Neill Maire , McCanny John 
Published: December 2010

Side-channel attacks (SCA) threaten electronic cryptographic devices and can be carried out by monitoring the physical characteristics of security circuits. Differential Power Analysis (DPA) is one the most widely studied side-channel attacks. Numerous countermeasure techniques, such as Random Delay Insertion (RDI), have been proposed to reduce the risk of DPA attacks against cryptographic devices. The RDI technique was first proposed for microprocessors but it was shown to be unsuccessful when implemented on smartcards as it was vulnerable to a variant of the DPA attack known as the Sliding-Window DPA attack.
Previous research by the authors investigated the use of the RDI countermeasure for Field Programmable Gate Array (FPGA) based cryptographic devices. A split-RDI technique was proposed to improve the security of the RDI countermeasure. A set of critical parameters was also proposed that could be utilized in the design stage to optimize a security algorithm design with RDI in terms of area, speed and power. The authors also showed that RDI is an efficient countermeasure technique on FPGA in comparison to other countermeasures.
In this article, a new RDI logic design is proposed that can be used to cost-efficiently implement RDI on FPGA devices. Sliding-Window DPA and realignment attacks, which were shown to be effective against RDI implemented on smartcard devices, are performed on the improved RDI FPGA implementation. We demonstrate that these attacks are unsuccessful and we also propose a realignment technique that can be used to demonstrate the weakness of RDI implementations.
Report on the second ACM workshop on hot topics in software upgrades (HotSWUp'09)
Authors: Dumitraş Tudor , Neamtiu Iulian , Tilevich Eli 
Published: December 2010

The Second ACM SIGPLAN Workshop on Hot Topics in Software Upgrades (HotSWUp'09) was held on 25 October 2009 in Orlando, FL. The workshop was co-located with OOPSLA 2009 and was sponsored by ACM SIGPLAN. Twenty researchers and practitioners, from the programming languages, systems, software engineering and database communities, attended HotSWUp'09.
The goal of HotSWUp is to identify, through interdisciplinary collaboration, cutting-edge research ideas for implementing software upgrades.
The workshop combined presentations of peer-reviewed research papers with invited presentations from well-known experts and a keynote speech on the practical issues related to performing large-scale upgrades. The audience included researchers and practitioners from academia, the industry (Facebook, ABB, Oracle) and the open-source community (AppUpdater). In addition to the technical presentations, the program allowed ample time for discussions, which were driven by debate questions provided in advance by the presenters
HotSWUp provides a premier forum for discussing problems that are often considered niche topics in the established research communities. For example, the technical discussions at HotSWUp'09 covered dynamic software updates, package management tools, database schema upgrades, upgrades of systems with real-time constraints, etc., and highlighted many synergies among these topics. Perhaps more interestingly, the industry presentations provided real-world examples of systems that a have strong requirement for online upgrades. These examples emphasized the magnitude of the software upgrade problems that the industry is facing today
Algorithmic information theory may explain the pathogenic number of DNA repeats in myotonic dystrophy type 1 (and in similar diseases)
Authors: Koshelev Misha , Longpré Luc 
Published: December 2010

Myotonic Dystrophy Type 1 (DM1), the most common form of adult-onset muscular dystrophy, is caused by an abnormal number of repeats of the trinucleotide sequence CTG outside of the protein-coding part of DNA -- more than fifty repeats can cause disease. Several other diseases are caused by similar repeats in non-coding regions; in most of these diseases, up to approximately fifty repeats is normal, while pathogenic cases usually have > 50 repetitions. The fact that this level of approximately fifty repeats can be seen in many diseases, with different repeating sequences, indicates that there may be a fundamental explanation for this threshold.
In this paper, we conjecture that such an explanation may come from Algorithmic Information Theory. Crudely speaking, this threshold can be viewed as a measure of the redundancy in healthy DNA; this indirect estimate of the measure of redundancy is in good accordance with a more direct estimate { based on the fact that approximately 1=50 of DNA is directly functionally useful (e.g., protein-coding).
SIGACT news algorithms column
Authors: Kuller Samir , Mahoney Michael W. 
Published: December 2010

The 2010 Workshop on Algorithms for Modern Massive Data Sets (MMDS 2010) was held at Stanford University, June 15-18. The goals of MMDS 2010 were (1) to explore novel techniques for modeling and analyzing massive, high-dimensional, and nonlinearly-structured scientific and Internet data sets; and (2) to bring together computer scientists, statisticians, applied mathematicians, and data analysis practitioners to promote cross-fertilization of ideas. MMDS 2010 followed on the heels of two previous MMDS workshops. The first, MMDS 2006, addressed the complementary perspectives brought by the numerical linear algebra and theoretical computer science communities to matrix algorithms in modern informatics applications [1]; and the second, MMDS 2008, explored more generally fundamental algorithmic and statistical challenges in modern large-scale data analysis [2].
The MMDS 2010 program drew well over 200 participants, with 40 talks and 13 poster presentations from a wide spectrum of researchers in modern large-scale data analysis. This included both academic researchers as well as a wide spectrum of industrial practitioners. As with the previous meetings, MMDS 2010 generated intense interdisciplinary interest and was extremely successful, clearly indicating the desire among many research communities to begin to distill out and establish the algorithmic and statistical basis for the analysis of complex large-scale data sets, as well as the desire to move increasingly-sophisticated theoretical ideas to the solution of practical problems.
Fixed Point and Best Proximity Theorems under Two Classes of Integral-Type Contractive Conditions in Uniform Metric Spaces
Authors: De la Sen M 
Published: December 2010

AbstractThis paper investigates the existence of fixed points and best proximity points of p-cyclic self-maps on a set of subsets of a certain uniform space under integral-type contractive conditions. The parallel properties of the associated restricted composed maps from any of the subsets to itself are also investigated. The subsets of the uniform space are not assumed to intersect.