bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nummulitic banks in the upper Lutetian ‘Buil level’, Ainsa Basin, South Central Pyrenean Zone: the impact of internal waves
Authors: MATEU‐VICENS GUILLEM , POMAR LUIS , FERRÀNDEZ‐CAÑADELL CARLES 
Published: August 2011

AbstractNummulites,a particularly abundant and diverse genus of larger benthonic foraminifera, formed huge accumulations (banks) during the Eocene, which are often good hydrocarbon reservoirs, especially in North Africa. Despite their economical interest, these accumulations are not well‐understood and their origin is still under discussion. Reasons for this debate are the absence of livingNummulitesaccumulations and the high‐variability of facies, including the size, shape and extension of the banks, which reflect the array of processes controlling sediment production and accumulation. The nummulitic banks near Santa María de Buil, in the Ainsa Basin (South Pyrenean Foreland Basin) are composed of recurrent facies associations within mappable bed units bounded by physical surfaces. The depositional processes that produced theNummulites deshayesiaccumulations are interpreted considering the shape of the banks, the type of bounding surfaces, the distribution of sedimentary textures,Nummulitestest shapes and the associated skeletal components within the banks. This integrative analysis indicates that nummulitic banks accumulated from mass flows, with very poor sediment sorting. Textural and compositional differences among banks suggest that globoseNummulitesthrived in the shallower part of the mesophotic zone with abundant nummulithoclasts, whereas flat nummulitic forms thrived in deeper mesophotic, clay‐dominated settings. Interbedded with nummulitic banks, coral biostromes and coral mounds bearingOperculina,DiscocyclinaandAsterocyclina, representin situaccumulation near the base of the photic zone. Internal waves (waves that propagate along the pycnocline) are thought to be the triggering mechanism for the density flows. Internal waves and induced bottom currents are sporadic but strong enough to bring sediments into suspension. In contrast to surface waves (both fair‐weather and storm), whose impact is strongest near the sea surface and decreases with bathymetry, the impact of internal waves is usually strongest in the mid‐shelf region and weaker in shallow water. This explains the compositional character of the nummulitic banks.
Mesophotic coral buildups in a prodelta setting (Late Eocene, southern Pyrenees, Spain): a mixed carbonate–siliciclastic system
Authors: MORSILLI MICHELE , BOSELLINI FRANCESCA R. , POMAR LUIS , HALLOCK PAMELA , AURELL MARC , PAPAZZONI CESARE A. 
Published: August 2011

AbstractLower Priabonian coral bioherms and biostromes, encased in prodelta marls/clays, occur in the Aínsa‐Jaca piggyback basin, in the South Central Pyrenean zone. Detailed mapping of lithofacies and bounding surfaces onto photomosaics reveals the architecture of coral buildups. Coral lithosomes occur either isolated or amalgamated in larger buildups. Isolated lithosomes are 1 to 8 m thick and a few hundred metres wide; clay content within coral colonies is significant. Stacked bioherms form low‐relief buildups, commonly 20 to 30 m thick, locally up to 50 m. These bioherms are progressively younger to the west, following progradation of the deltaic complex. The lowermost skeletal‐rich beds consist of bryozoan floatstone with wackestone to packstone matrix, in which planktonic foraminifera are abundant and light‐related organisms absent. Basal coral biostromes, and the base of many bioherms, consist of platy‐coral colonies ‘floating’ in a fine‐grained matrix rich in branches of red algae. Corals with domal or massive shape, locally mixed with branching corals and phaceloid coral colonies, dominate buildup cores. These corals are surrounded by matrix and lack organic framework. The matrix consists of wackestone to packstone, locally floatstone, with conspicuous red algal and coral fragments, along with bryozoans, planktonic and benthonic foraminifera and locally sponges. Coral rudstone and skeletal packstone, with wackestone to packstone matrix, also occur as wedges abutting the buildup margins. Integrative analysis of rock textures, skeletal components, buildup anatomy and facies architecture clearly reveal that these coral buildups developed in a prodelta setting where shifting of delta lobes or rainfall cycles episodically resulted in water transparency that allowed zooxanthellate coral growth. The bathymetric position of the buildups has been constrained from the light‐dependent communities and lithofacies distribution within the buildups. The process‐product analysis used here reinforces the hypothesis that zooxanthellate corals thrived in mesophotic conditions at least during the Late Eocene and until the Late Miocene. Comparative analysis with some selected Upper Eocene coral buildups of the north Mediterranean area show similarities in facies, components and textures, and suggest that they also grew in relatively low light (mesophotic) and low hydrodynamic conditions.
Evidence for late Mesoproterozoic tectonism in northern Yukon and the identification of a Grenville‐age tectonothermal belt in western Laurentia
Authors: Milidragovic Dejan , Thorkelson Derek J. , Davis William J. , Marshall Daniel D. , Gibson H. Daniel 
Published: August 2011

Terra Nova, 23, 307–313, 2011AbstractNew U‐Pb zircon dates from gneissic xenoliths in an Early Cambrian lamprophyre point to late Mesoproterozoic metamorphism and magmatism in the crust beneath northern Yukon. The data indicate a previously unrecognized thermal event in Yukon and extend the recognition of widely spaced 1.3–1.0 Ga igneous, metamorphic and tectonic events along the western margin of Laurentia. Together, these events demonstrate that the north‐western margin of Laurentia was thermally active during a period of traditionally inferred tectonic quiescence. The tectonic setting, intensity and general nature of this late Mesoproterozoic tectonothermal activity are poorly constrained, but their recognition is key to expanding our understanding of the Proterozoic geology of North America. The recognition of this event places new constraints on the palaeotectonic reconstructions of the supercontinent Rodinia.
Glucose and ethylene signalling pathways converge to regulate trans‐differentiation of epidermal transfer cells in Vicia narbonensis cotyledons
Authors: Andriunas Felicity A. , Zhang Hui‐Ming , Weber Hans , McCurdy David W. , Offler Christina E. , Patrick John W. 
Published: August 2011

SummaryTransfer cells are specialized transport cells containing invaginated wall ingrowths that provide an amplified plasma membrane surface area with high densities of transporter proteins. They trans‐differentiate from differentiated cells at sites where enhanced rates of nutrient transport occur across apo/symplasmic boundaries. Despite their physiological importance, the signal(s) and signalling cascades responsible for initiating their trans‐differentiation are poorly understood. In culture, adaxial epidermal cells of Vicia narbonensis cotyledons were induced to trans‐differentiate to a transfer cell morphology. Manipulating their intracellular glucose concentrations by transgenic knock‐down of ADP‐glucose pyrophosphorylase expression and/or culture on a high‐glucose medium demonstrated that glucose functioned as a negative regulator of wall ingrowth induction. In contrast, glucose had no detectable effect on wall ingrowth morphology. The effect on wall ingrowth induction of culture on media containing glucose analogues suggested that glucose acts through a hexokinase‐dependent signalling pathway. Elevation of an epidermal cell‐specific ethylene signal alone, or in combination with glucose analogues, countered the negative effect of glucose on wall ingrowth induction. Glucose modulated the amplitude of ethylene‐stimulated wall ingrowth induction by down‐regulating the expression of ethylene biosynthetic genes and an ethylene insensitive 3 (EIN3)‐like gene (EIL) encoding a key transcription factor in the ethylene signalling cascade. A model is presented describing the interaction between glucose and ethylene signalling pathways regulating the induction of wall ingrowth formation in adaxial epidermal cells.
Facial asymmetry and clinical manifestations in patients with novel insertion of theTCOF1gene
Authors: Su P‐H , Liu Y‐F , Yu J‐S , Chen J‐Y , Chen S‐J , Lai Y‐J 
Published: August 2011

Su P‐H, Liu Y‐F, Yu J‐S, Chen J‐Y, Chen S‐J, Lai Y‐J. Facial asymmetry and clinical manifestations in patients with novel insertion of theTCOF1gene.This study explored the role ofTCOF1insertion mutations in Taiwanese patients with craniofacial anomalies. Twelve patients with single or multiple, asymmetrical congenital craniofacial anomalies were enrolled. Genomic DNA was prepared from leukocytes; the coding regions ofTCOF1were analyzed by polymerase chain reaction and direct sequencing. Clinical manifestations were correlated to theTCOF1mutation. Six of 12 patients diagnosed with hemifacialmicrosomia exhibited a novel insertion mutation 4127 ins G (frameshift) in exon 24 in theTCOF1gene. All six patients were diagnosed with anomalies on the left side. In addition, four of these six patients had hearing impairment; three had other major anomalies; and two had developmental delay. The insertion caused a frameshift, an early truncation, the loss of two putative nuclear localization signals (residues 1404–1420 and 1424–1440), and the loss of coiled coil domain (1406–1426) in treacle protein. These findings support the existence of two regulators of growth of the mandibular condyles.
Patients’ statements and experiences concerning receiving mechanical ventilation: a prospective video‐recorded study
Authors: Karlsson Veronika , Lindahl Berit , Bergbom Ingegerd 
Published: August 2011

KARLSSON V, LINDAHL B and BERGBOM I. Nursing Inquiry 2012; 19: 247–258  Patients’ statements and experiences concerning receiving mechanical ventilation: a prospective video‐recorded studyProspective studies using video‐recordings of patients during mechanical ventilator treatment (MVT) while conscious have not previously been published. The aim was to describe patients’ statements, communication and facial expressions during a video‐recorded interview while undergoing MVT. Content analysis and hermeneutics inspired by the philosophy of Gadamer were used. The patients experienced almost constant difficulties in breathing and lost their voice. The most common types of communication techniques patients used were nodding or shaking the head. Their expressions were interpreted as stiffened facial expression, tense body position and feelings of sadness and sorrow. Nursing care for patients’ conscious during MVT is challenging as it creates new demands regarding the content of the care provided. In caring for patients undergoing MVT while conscious, establishing a caring relationship, making patients feel safe and helping them to communicate seem to be most important for alleviating discomfort and instilling hope.
Faecal impaction: in‐hospital complications and their predictors in a retrospective study on 130 patients
Authors: Halawi Houssam M. , Maasri Karim A. , Mourad Fadi H. , Barada Kassem A. 
Published: August 2011

AbstractAim  Faecal impaction may be a medical emergency. The frequency of complications of this condition and their predictors are not known. We determined the clinical presentation, the in‐hospital complications and their predictors in 130 patients diagnosed with faecal impaction.Method  This was a retrospective study of the medical records of 130 patients who presented with faecal impaction to a tertiary care center in Beirut, Lebanon, between 1992 and 2009. The clinical outcome and complications were reviewed. The association between in‐hospital complications and other variables was determined.Results  The mean age of the patients was 67.1 years. Ninety‐eight (75.3%) patients had at least one of the following: heart disease (36.3%), neurological disease (28.8%) or diabetes (22.6%), and 26.7% were bedridden. The site of impaction was the rectum in 66.4%. The patients were treated by manual disimpaction (34.5%), enema (89.1%) or oral laxatives (84.0%). A delay in treatment of more than 6 h occurred in 70 (53.8%) patients. In‐hospital complications occurred in 34 (24.6%) patients, the most common of which were infectious (16 cases), systemic inflammatory response syndrome (16 cases), cardiopulmonary (14 cases) and death (one patient). Time to the start of treatment was longer in patients who developed complications compared with those who did not (10.1 h vs 7.1 h; P = 0.02). Patients > 80 years of age, or patients with heart or neurological disease were at a higher risk of developing complications (P = 0.03, P = 0.03 and P = 0.02, respectively).Conclusion  Treatment delay, increasing age and the presence of heart or neurological disease seem to be predictors of in‐hospital complications in patients with faecal impaction.
Instrumental and clinical studies of the facial skin tone and pigmentation of Shanghaiese women. Changes induced by age and a cosmetic whitening product
Authors: Huixia Q. , Xiaohui L. , Chengda Y. , Yanlu Z. , Senee J. , Laurent A. , Bazin R. , Flament F. , Adam A. , Piot B. 
Published: August 2011

SynopsisThe pigmentation patterns of facial skin of 354 healthy Chinese women aged 18–80 years were investigated clinically and instrumentally. Chromasphere® was used to acquire pictures from the cheeks of subjects. Facial skin tone was described by L* parameter from the L,a,b system as well as Individual Typology Angle (ITA). Results show that skin tone becomes significantly darker along the life span. Both size of hyper‐pigmented spots and their contrast with surrounding skin were found increased with age. As additional study, 40 women from these 354 subjects were asked to apply daily a whitening cosmetic product for a 2‐month period. Such application led to a significantly lighter skin tone, although this study was not vehicle controlled and we cannot exclude that the increase in L* observed was in some part because of cumulative effects of previously used whitening products, there was an association with lighter skin tone as assessed through both instrumental measurements and self‐perception by most subjects.
‘Blame it on marketing’: consumers' views on unsustainable consumption
Authors: Pereira Heath M. Teresa , Chatzidakis Andreas 
Published: August 2011

AbstractThis paper addresses consumers' attitudes towards consumption, the extent to which excessive consumption is perceived as an environmental problem and what consumers perceive as their personal responsibility vs. that of marketing for this consumption. Findings from a focus group and a survey administered to lecturers of a university in Portugal are reported. A critical reflection upon the findings reveals that participants view consumption as excessive and mostly due to marketing, but do not associate high levels of consumption with environmental damage. The consumers surveyed did not accept personal responsibility for excessive consumption, and many of them do not perceive their actions to have a significant impact on the environment. The high educational level of our sample makes these findings of particular concern. This paper feeds the debate on sustainable marketing and expresses the need to address consumers', as well as marketing's, place in sustainability. Implications of this study are drawn and directions for future research are suggested.
N‐terminal deletion does not affect α‐synuclein membrane binding, self‐association and toxicity in human neuroblastoma cells, unlike yeast
Authors: Vamvaca Katherina , Lansbury Jr. Peter T. , Stefanis Leonidas 
Published: August 2011

J. Neurochem. (2011) 119, 389–397.Abstractα‐Synuclein causes Parkinson’s disease if mutated or aberrantly produced in neurons. α‐Synuclein–lipid interactions are important for the normal function of the protein, but can also contribute to pathogenesis. We previously reported that deletion of the first 10 N‐terminal amino acids dramatically reduced lipid binding in vitro, as well as membrane binding and toxicity in yeast. Here we extend this study to human neuroblastoma SHSY‐5Y cells, and find that in these cells the first 10 N‐terminal residues do not affect α‐synuclein membrane binding, self‐association and cell viability, contrary to yeast. Differences in lipid composition, membrane fluidity and cytosolic factors between yeast and neuronal cells may account for the distinct binding behavior of the truncated variant in these two systems. Retinoic acid promotes differentiation and α‐synuclein oligomer formation in neuroblastoma cells, while addition of a proteasomal inhibitor induces neurite outgrowth and toxicity to certain wild‐type and truncated α‐synuclein clones. Yeast recapitulate several features of α‐synuclein (patho)biology, but its simplicity sets limitations; verification of yeast results in more relevant model systems is, therefore, essential.
Hyperforin promotes mitochondrial function and development of oligodendrocytes
Authors: Wang Yanlin , Zhang Yanbo , He Jue , Zhang Handi , Xiao Lan , Nazarali Adil , Zhang Zhijun , Zhang Dai , Tan Qingrong , Kong Jiming , Li Xin‐Min 
Published: August 2011

J. Neurochem. (2011) 119, 555–568.AbstractSt. John’s wort has been found to be an effective and safe herbal treatment for depression in several clinical trials. However, the underlying mechanism of its therapeutic effects is unclear. Recent studies show that the loss and malfunction of oligodendrocytes are closely related to the neuropathological changes in depression, which can be reversed by antidepressant treatment. In this study, we evaluated the effects of hyperforin, a major active component of St. John’s wort, on the proliferation, development and mitochondrial function of oligodendrocytes. The study results revealed that hyperforin promotes maturation of oligodendrocytes and increases mitochondrial function without affecting proliferation of an oligodendrocyte progenitor cell line and neural stem/progenitor cells. Hyperforin also prevented mitochondrial toxin‐induced cytotoxicity in an oligodendrocyte progenitor cell line. These findings suggest that hyperforin may stimulate the development and function of oligodendrocytes, which could be a mechanism of its effect in depression. Future in vitro and in vivo studies are required to further characterize the mechanisms of hyperforin.
Development and Hydrodynamic Evaluation of a Novel Inflow Cannula in a Mechanical Circulatory Support System for Bridge to Decision
Authors: Sumikura Hirohito , Toda Koichi , Takewa Yoshiaki , Tsukiya Tomonori , Ohnuma Kentaro , Sasagawa Mitsuo , Watanabe Fumikazu , Ugawa Junichi , Taenaka Yoshiyuki , Tatsumi Eisuke 
Published: August 2011

AbstractRecent progress in the development of implantable rotary blood pumps realized long‐term mechanical circulatory support (MCS) for bridge to transplant, bridge to recovery, or a destination therapy. Meanwhile, a short‐term MCS system is becoming necessary for bridge to decision. We developed a novel inflow cannula for the short‐term MCS system, which gives sufficient bypass flow with minimal invasion at insertion, and evaluated its hydrodynamic characteristics. The novel inflow cannula, named the Lantern cannula, is made of elastic silicone reinforced with metal wires. The cannula tip has six slits on the side. This cannula tip can be extended to the axial direction by using an introducer and can be reduced in diameter, and the Lantern cannula enables easy insertion into the left ventricle apex with minimal invasion. The sufficient bypass flow rate can be obtained due to low pressure loss. Moreover, this Lantern shape also resists suction complication around the cannula tip. The pressure loss through the Lantern cannula was measured using a mock circulation and compared with two commercially available venous cannulae (Sarns4882, Terumo, Tokyo, Japan and Stockert V122‐28, Sorin Group, Tokyo, Japan), which have almost same diameter as the Lantern cannula. Moreover, the flow patterns around the cannula tip were numerically analyzed by computational fluid dynamics (CFD). Acute animal experiment was also performed to confirm the practical effectiveness of the Lantern cannula. The pressure loss of the Lantern cannula was the lowest compared with those of the commercially available venous cannulae in in vitro experiment. CFD analysis results demonstrated that the Lantern cannula has low pressure loss because of wide inflow orifice area and a bell mouth, which were formed via Lantern shape. The highest bypass flow was obtained in the Lantern cannula because of the low pressure loss under pulsatile condition in in vivo experiments. The Lantern cannula demonstrated superior hydrodynamic characteristics as the inflow cannula in terms of pressure loss due to its specially designed Lantern shape.
Identification of Unusual Reentry Circuit Sites of Nonischemic Ventricular Outflow Tract Tachycardia
Authors: NAKANO EMI , HARADA TOMOO , AONUMA KAZUTAKA , SOEJIMA KYOKO , WAKIMOTO HIROFUMI , MATSUMOTO NAOKI , MIYAKE FUMIHIKO 
Published: August 2011

Identification of Ventricular Outflow Tract Tachycardia. Background: Reentrant ventricular outflow tract (OT) tachycardia is rare in patients with nonischemic heart disease. The mechanism of ventricular tachycardia (VT) arising from the region of the aortic sinus of Valsalva (ASOV) is usually focal, rather than reentrant. Consequently, less is known about reentrant circuits in the OT and the aortic sinuses. The purpose of this study was to evaluate existence of reentry circuits in these areas using entrainment mapping techniques.
Methods:
We performed electrophysiological study in 51 consecutive patients with idiopathic or nonischemic symptomatic VT arising from the OT. Six of these patients were found to have VT of reentrant mechanism with 8 VT morphologies. Entrainment mapping, electroanatomical mapping (in 2 patients), and radiofrequency catheter ablation were performed.
Results:
Pacing entrained the VT at 93 sites, 52 of which were determined to be in the reentry circuit based on matching of the postpacing interval and VT cycle length. Of the reentry circuit sites, 6 were in the aortic sinus, 43 were below the aortic valve, and 3 were in the right OT below the pulmonary valve. Classification of reentry circuit sites identified 7 as exit, 1 as central‐proximal, 19 as inner loop, and 25 as outer loop sites. Catheter ablation terminated VT at 4 of the 6 aortic sinus sites and 4 of the 46 OT sites (P = 0.0006).
Conclusions:
We definitively demonstrated involvement of the ASOV in OT reentrant tachycardia using entrainment mapping. It may be useful for successful VT ablation to identify reentry circuit localization. (J Cardiovasc Electrophysiol, Vol. 23, pp. 179‐187, February 2012)
Response to Immunotherapy in CLIPPERS: Clinical, MRI, and MRS Follow‐Up
Authors: Sempere Angel P. , Mola Santiago , Martin‐Medina Patricia , Bernabeu Angela , Khabbaz Elias , Lopez‐Celada Susana 
Published: August 2011

ABSTRACTChronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a recently defined inflammatory central nervous system disorder responsive to steroids with characteristic magnetic resonance imaging (MRI) features. We report a 69‐year‐old man presenting with gait ataxia with the characteristic MRI features of CLIPPERS and describe the clinical, MRI, and magnetic resonance spectroscopy (MRS) follow‐up after treatment with glucocorticosteroids. Brain and spine MRI showed punctate enhancement peppering the brainstem, cerebellar peduncles, and upper cervical cord. In MRS, the ratio of N‐acetyl aspartate to creatine (NAA/Cr) was significantly decreased in the pons and both thalami. An extensive evaluation found no alternative diagnoses. Treatment with steroids led to rapid clinical improvement. Repeat MRI and MRS showed complete resolution of gadolinium‐enhancing lesions and recovery of NAA/Cr levels in the pons and thalami. After 1 month of tapering oral steroids, weekly oral methotrexate was started and the patient has remained stable for the past 6 months.