bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Literasi dan Promosi terhadap Penggunaan Shopee Paylater (Studi Mahasiswa Pascasarjana IAIN Parepare)
Authors: Fawzy Ramadhan Andi Muhammad , Nurhayati St. , Damirah Damirah , Semaun Syahriyah , Bahri S Andi 
Published: May 2024

Shopee Paylater's current usage has increased drastically as a result of the post-pandemic transition of its majority millennial user transactions especially among college students whose majority is literacy and promotion as a factor of influence. The purpose of this research is to find out the influence of literacy and promotion on the use of Shopeepay paylater on postgraduate students of IAIN Parepare. Result Research is a field research (Field Research) which is quantitative with an associative approach to knowing the influence of literacy and promotion on the use of Shopeepay paylater in postgraduate students of IAIN Parepare. The data analysis techniques used are quantitative descriptive with an associative approach. Which aims to find out the relationship between two variables or more.Research results show that: (1) Literacy (X1) has a significant influence on the use of Shopeepay paylater, proven with a significance value of 0,000 > 0.05 and a regression coefficient of 0.724.(2) Promotion (X2) has a significant influence on the use of Shopeepay paylater, demonstrated with a significance value of 0,801 < 0,05 and a regression coefficient of 0,037. (3) Then literacy (X1) and promotion (X2) have simultaneously or jointly influenced the use of Shopeepay paylater, proving a F-count value of 25,736 > F-table is 3.11 with a sig. p= 0,000 < 0.05.
Surgeries and Outcomes in Subluxated and Dislocated Lens in Eastern Nepal
Authors: Shrestha Pranav , Sharma Sadhana , Suwal Rinkal , Joshi Purushottam , Subedi Prava 
Published: May 2024

Introduction: Many ocular or systemic conditions can cause weakening of the zonules, leading to subluxation or complete dislocation of lens into the anterior chamber or vitreous cavity.
Objectives: To evaluate the outcome of surgery in cases with subluxated and dislocated lens.
Materials and methods: Retrospective chart review of all cases with subluxated and dislocated lens who underwent surgery in a one-year period from 2019 January to 2019 December was conducted. Demographic profile, systemic comorbidities, initial and final best corrected visual acuity (BCVA), surgical procedure were recorded along with all the intraoperative and post-operative complications.
Results: A total of 62 eyes of 60 patients with mean age of 50.18 ± 15.18 years (18 to 87 years) were included with the modal duration of presentation of one week. Among these, trauma was found to be the most common etiology. Subluxation was present in 55 eyes and seven eyes had dislocation. Intracapsular Cataract Extraction (ICCE) was performed in 41 while 21 underwent Extracapsular Cataract Extraction (ECCE); and surgical intervention elicited a statistically significant (p < 0.05) improvement in the visual acuity. The BCVA was statistically better among the pseudophakic patient. Most common complication encountered intraoperatively was vitreous loss and post operatively was significant corneal edema.
Conclusion: Cataract extraction in cases with subluxated and dislocated lens due to different etiology results in the improvement in the visual acuity of the patient. In cases where ECCE cannot be performed, ICCE also results in comparable visual improvement.
Forecasting the 20-Year Incidence of Dementia by Socioeconomic Status, Race/Ethnicity, and Region Based on Mid-Life Risk Factors in a U.S. Nationally Representative Sample
Authors: Churchill Nicola , Barnes Deborah E. , Habib Mina , Nianogo Roch A. 
Published: May 2024

Background: Alzheimer’s disease and related dementias (ADRD) incidence varies based on demographics, but mid-life risk factor contribution to this variability requires more research. Objective: The purpose of this study is to forecast the 20-year incidence of dementia in the U.S. overall and stratified by race/ethnicity, socioeconomic status (SES), and U.S. geographic region given prior mid-life risk factor prevalence and to examine the extent to which risk factor differences 20 years ago may explain current SES, race/ethnicity, or regional disparities in dementia incidence. Methods: We applied the Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) prediction model to the 2006 wave of the Health and Retirement Study (HRS) in participants aged 45 to 64 to estimate the 20-year risk of incident ADRD. Results: The 20-year risk of dementia among middle-aged Americans was 3.3% (95% CI: 3.2%, 3.4%). Dementia incidence was forecast to be 1.51 (95% CI: 1.32, 1.71) and 1.27 (95% CI: 1.14, 1.44) times that in Hispanic and Non-Hispanic Black individuals respectively compared statistically to Non-Hispanic White individuals given mid-life risk factors. There was a progressive increase in dementia risk from the lowest versus highest SES quintile. For geographic region, dementia incidence was forecast to be 1.17 (95% CI: 1.06, 1.30) and 1.27 (95% CI: 1.14, 1.43) times that in Midwestern and Southern individuals respectively compared statistically to Western individuals. Conclusions: Some disparities in dementia incidence could be explained by differences in mid-life risk factors and may point toward policy interventions designed to lessen the ADRD disease burden through early prevention.
Relationship Between Hand Strength and Function in Duchenne Muscular Dystrophy and Spinal Muscular Atrophy: Implications for Clinical Trials
Authors: Decostre Valérie , De Antonio Marie , Servais Laurent , Hogrel Jean-Yves 
Published: May 2024

Background: Measurement of muscle strength and motor function is recommended in clinical trials of neuromuscular diseases, but the loss of hand strength at which motor function is impacted is not documented. Objectives: To establish the relationship between hand strength and function, and to determine the strength threshold that differentiates normal and abnormal hand function in individuals with Duchenne Muscular Dystrophy (DMD) or Spinal Muscular Atrophy (SMA). Methods: Maximal handgrip and key pinch strength were measured with the MyoGrip and MyoPinch dynamometers, respectively. Hand function was assessed using the MoviPlate, the Motor Function Measure items for distal upper limb (MFM-D3-UL) and the Cochin Hand Function Scale (CHFS). Results: Data from 168 participants (91 DMD and 77 SMA, age 6–31 years) were analyzed. Relationships between strength and function were significant ( P < 0.001). Hand function was generally preserved when strength was above the strength threshold determined by Receiver-Operating Characteristic (ROC) analysis: For MFM-D3-UL, the calculated handgrip strength thresholds were 41 and 13% of the predicted strength for a healthy subject (% pred) and the key pinch strength thresholds were 42 and 26% pred for DMD and SMA, respectively. For the MoviPlate, handgrip strength thresholds were 11 and 8% pred and key pinch strength thresholds were 21 and 11% pred for DMD and SMA, respectively. For participants with sub-threshold strength, hand function scores decreased with decreasing strength. At equal % pred strength, individuals with SMA had better functional scores than those with DMD. Conclusions: Hand function is strength-dependent for most motor tasks. It declines only when strength falls below a disease-specific threshold. Therefore, therapies capable of maintaining strength above this threshold should preserve hand function.
ExoBand, A Passive Wearable Device as a Walking Aid in Neuromuscular Patients: First Quantitative Assessment
Authors: Semplicini Claudio , Agostini Michela , Andrigo Cinzia , Masiero Stefano , Piccione Francesco , Sorarù Gianni 
Published: May 2024

Objective: Exoband (by Moveo, Padova, Italy) functions as a walking brace, comprising a belt and two leg loops connected by a mechanism that stores energy during the initial phase of the gait cycle and releases it in the subsequent phase. This enhances hip flexor thrust, leading to functional improvement in walking for individuals with conditions characterized by proximal weakness. It has been approved as a passive wearable device for individuals with impaired walking abilities. Objective of this study was to establish a protocol to assess the use of Exoband in patients with various neuromuscular disorders. Methods: This exploratory retrospective study includes consecutive patients diagnosed with neuromuscular disorders (CIDP, motor polyneuropathy, MND), exhibiting a proximal involvement and gait abnormalities. The evaluation protocol incorporated specific walking-related outcome measures, the 10-meter walk test (10mWT), Time-up-and-go test (TUG), and 2-minute walking test (2MWT). The assessments were conducted both with and without the Exoband under standard conditions. Results: Eight patients (6 males, aged 60–78 years) were tested. An increase in velocity was observed in the 10mWT (median 13.4 sec, IQR 12.0–15.7 vs. 12.2 sec, IQR 11.3–14.2 seconds, p < 0.05) and the TUG (14.0 sec, IQR 13–16.2 vs 13.35 sec, IQR 11–13.8; p < 0.05, by non-parametric Wilcoxon test), and a trend of increase in 2MWT (median 88.2 vs 92.6 m, n.s.). Six out of 8 patients reported subjective benefits from the very first use, including improved walking stability, speed, confidence, and reduced fatigue. Conclusions: Our protocol provides a quantitative assessment of Exoband usefulness for patients affected by neuropathies with gait abnormalities. Further investigations are warranted to assess the long-term effects of its regular Exoband use, its efficacy in specific neuromuscular diseases, and its potential role as a rehabilitation device.
FAOSTAT Food Value Chain Domain implementation: Input Output modelling and analytical applications
Authors: Cerilli Silvia , Vollaro Michele , Boero Veronica , d’Ortigue Olivier Lavagne , Yi Jing 
Published: May 2024

The recent increasing attention to the economic and policy analysis of the food systems from international fora, public institutions and academia calls for the availability of information and data capable of informing about the interrelations across economic sectors and within value chains. The international policy agenda is pushing for a more effective application of measures at country and regional level in line with the recommendations of the 2030 Agenda and its Sustainable Development Goals, for which more systematic and integrated data about economic, social and environmental impacts of policies are requested. The Food Value Chain Domain recently published in FAOSTAT responds to this call. Its data and information shed light on the distribution of final domestic food expenditures across industries (Agriculture, Food Processing, Wholesale, Retail, Accommodations and Food Services) and primary factors (e.g.: Labour, Gross Operating Surplus) on the relative food value chain. The FAOSTAT Domain offers therefore robust and granular information on both the farm and the post-farm gate component of the Food Value Chain. The applied Global Food Dollar methodology, that FAO is contributing to upscale at global level, is based on Leontief decomposition approach on the Input-Output tables. Moreover, whenever the Input-Output table are not available, it is now possible to impute them from Supply-Use tables by applying a conversion methodology, developed by FAO in compliance with European (EUROSTAT), United Nations (UNSD) and international statistical standards as the System of National Accounts. This allows to extend the analysis to several African, Asian, and Latin American countries that produce on regular basis only Supply and Use Tables, and not Industry by industry Input Output Tables. The potential time and data coverage of the methodology is therefore significantly expanded. The aim of this paper is to describe the conceptual framework of the conversion methodology of Supply-Use Tables into Input-Output Tables of the Global Food Dollar methodology, and the potential implementation scope of these methodologies. Preliminary analytical findings of the applied methodologies are presented as well. The new methods and data presented in this paper, being based on data compliant with the International Statistical Standards, as the System of National Accounts, and therefore comparable across countries, associated to larger data availability, have the potential to effectively support food policies at international, regional and national level, as well as contribute to a decision making in line with the 2030 Agenda.
Dizziness-related disability in persons with post-COVID condition: A cross sectional study
Authors: Östlind Elin , Ekstrand Elisabeth , Axén Iben , Brogårdh Christina , Fänge Agneta Malmgren , Stigmar Kjerstin , Ekvall Hansson Eva 
Published: May 2024

BACKGROUND: Dizziness is a common symptom in post-COVID condition (PCC) which may have a large impact on several life domains. However, knowledge on dizziness-severity and disability in PCC is sparse. OBJECTIVE: The aim was to describe the severity of dizziness-related disability in individuals with PCC, and how it is manifested in daily life. METHODS: A questionnaire regarding symptoms of PCC, health, and dizziness-related handicap was administered online, and 524 persons with PCC and dizziness were included. RESULTS: Mean score of the Dizziness Handicap Inventory was 35.2 (24.0) and 51.8%, were classified as having moderate/severe dizziness-related disability. The percentage of maximum value for the subscales were: Physical manifestation, 48%, Emotional Impact, 36% and Catastrophic Impact, 17%. The greatest influence on physical movements was when bending forward, head shaking or doing strenuous physical activities or household chores. CONCLUSIONS: Half had moderate or severe dizziness-related disability and the physical manifestations occurred mostly during specific or strenuous body movements. This indicate a vestibular impairment that may be effectively managed with vestibular rehabilitation. Assessment and treatment of dizziness might be an essential part in PCC rehabilitation and future research should continue to explore the potential causal pathways of dizziness in PCC.
The Environmental Drivers of Canadian Beach Water Quality
Authors: Young Ian , Tustin Jordan , Sanchez Johanna , Desta Binyam Negussie 
Published: May 2024

<p> Understanding and predicting the environmental drivers of recreational water quality, measured by E. coli concentration, can support public health decision making. We present the results of analyses conducted at beaches in the following four regions in Canada: Toronto, Niagara Regon, Manitoba, and Vancouver</p>
Contamination, morphological and chemical characterization, and hazard risk analyses of microplastics in drinking water sourced from groundwater in a developing nation
Authors: Paray Bilal Ahamad , Yu Jimmy , Sultana Salma , Banik Partho , Nur As-Ad Ujjaman , Haque Md. Rashedul , Rahman Md. Mostafizur , Arai Takaomi , Yan Li , Hossain M. Belal 
Published: May 2024

Groundwater (GW) plays a crucial role as the primary source of potable water in numerous developing nations. However, the increasing presence of microplastics (MPs) represents a concealed danger, threatening activities that guarantee safe drinking water in these countries. Despite this, there is limited awareness about the widespread existence of MPs in these regions of the world. In this study, we investigated the contamination levels, distribution, morphological characteristics, chemical composition, and associated public health risk of MPs in groundwater samples from six coastal districts of Bangladesh using stereomicroscopy and Fourier transform infrared spectroscopy (FTIR). MPs were prevalent at all sampling stations, with average concentrations of 24.63 ± 16.13 items/L and a range of 4–75 items/L. The majority of MPs (97.6%) were fibers, indicating a likely origin from fabric disintegration during drying, washing, discarded fishing nets, personal care items, and municipal waste. Smaller-sized MPs (&lt;0.5 mm), transparent and violet-colored, were predominantly observed. Additionally, FTIR confirmed the presence of plastic polymers, including low-density polyethylene (LDPE), high-density polyethylene (HDPE), ethylene vinyl acetate (EVA), and polyethylene terephthalate (PETE). Despite the high visibility observed or focus given for PETE, PE was found to be abundant. These are thought to have come from runoff from agricultural fields, seeping from landfills where plastic trash is disposed of, synthetic fabrics, and inappropriate plastic product disposal. Estimated dietary intake was recorded as 1.85 particles/person/day (i.e., 675 particles/year), suggesting the possible health risk to consumers. Hazard analyses based on the polymeric risk score revealed diverse risks associated with polymer levels, with PETE indicating a medium risk and other polymers, e.g., HDPE, LDPE, and EVA at 39%, 31%, and 17%, respectively, showing a minor risk to human health from drinking water from the studied sources. This is the first study from the regions, and the findings will be valuable for identifying sources, implementing control measures, shaping policies, and safeguarding public health against plastic pollution.
Whole-genome resequencing reveals genomic variation and dynamics in Ethiopian indigenous goats
Authors: Sheriff Oumer , Ahbara Abulgasim M. , Haile Aynalem , Alemayehu Kefyalew , Han Jian-Lin , Mwacharo Joram M. 
Published: May 2024

Ethiopia has about 52 million indigenous goats with marked phenotypic variability, which is the outcome of natural and artificial selection. Here, we obtained whole-genome sequence data of three Ethiopian indigenous goat populations (Arab, Fellata, and Oromo) from northwestern Ethiopia and analyzed their genome-wide genetic diversity, population structure, and signatures of selection. We included genotype data from four other Ethiopian goat populations (Abergelle, Keffa, Gumuz, and Woyto-Guji) and goats from Asia; Europe; and eastern, southern, western, and northern Africa to investigate the genetic predisposition of the three Ethiopian populations and performed comparative genomic analysis. Genetic diversity analysis showed that Fellata goats exhibited the lowest heterozygosity values (Ho = 0.288 ± 0.005 and He = 0.334 ± 0.0001). The highest values were observed in Arab goats (Ho = 0.310 ± 0.010 and He = 0.347 ± 4.35e−05). A higher inbreeding coefficient (FROH = 0.137 ± 0.016) was recorded for Fellata goats than the 0.105 ± 0.030 recorded for Arab and the 0.112 ± 0.034 recorded for Oromo goats. This indicates that the Fellata goat population should be prioritized in future conservation activities. The three goat populations showed the majority (∼63%) of runs of homozygosity in the shorter (100–150 Kb) length category, illustrating ancient inbreeding and/or small founder effects. Population relationship and structure analysis separated the Ethiopian indigenous goats into two distinct genetic clusters lacking phylogeographic structure. Arab, Fellata, Oromo, Abergelle, and Keffa represented one genetic cluster. Gumuz and Woyto-Guji formed a separate cluster and shared a common genetic background with the Kenyan Boran goat. Genome-wide selection signature analysis identified nine strongest regions spanning 163 genes influencing adaptation to arid and semi-arid environments (HOXC12, HOXC13, HOXC4, HOXC6, and HOXC9, MAPK8IP2), immune response (IL18, TYK2, ICAM3, ADGRG1, and ADGRG3), and production and reproduction (RARG and DNMT1). Our results provide insights into a thorough understanding of genetic architecture underlying selection signatures in Ethiopian indigenous goats in a semi-arid tropical environment and deliver valuable information for goat genetic improvement, conservation strategy, genome-wide association study, and marker-assisted breeding.
A novel locus in CSMD1 gene is associated with increased susceptibility to severe malaria in Malian children
Authors: Damena Delesa , Barry Amadou , Morrison Robert , Gaoussou Santara , Mahamar Almahamoudou , Attaher Oumar , Issiaka Djibrilla , Dicko Yahia , Dicko Alassane , Duffy Patrick , Fried Michal 
Published: May 2024

BackgroundPlasmodium falciparum malaria is still a leading cause of child mortality in sub-Saharan Africa. The clinical manifestations of malaria range from asymptomatic infection to severe disease. The variation in clinical presentation is partly attributed to host genetic factors with estimated narrow-sense heritability of 23%. Here, we investigate the associations between candidate gene polymorphisms and the likelihood of severe malaria (SM) in a cohort of Malian children.MethodsBased on our previous genome-wide association studies (GWAS) analysis, candidate genes were selected for in-depth analysis using several criteria including gene-level GWAS scores, functional overlap with malaria pathogenesis, and evidence of association with protection or susceptibility to other infectious or inflammatory diseases. Single Nucleotide Polymorphisms (SNPs) residing within these genes were selected mainly based on p-values from previous severe malaria susceptibility GWAS studies and minor allele frequency (MAF) in West African populations.ResultsOf 182 candidate genes reported in our previous study, 11 genes and 22 SNPs residing in these genes were selected. The selected SNPs were genotyped using KASP technology in 477 DNA samples (87 SM and 390 controls). Logistic regression analysis revealed that a common intron variant, rs13340578 in CUB and Sushi Multi Domain (CSMD1) gene, is associated with increased odds of SM in recessive mode of inheritance (MAF = 0.42, OR = 1.8, 95% CI = [1.78, 1.84], p = 0.029). The SNP is in linkage disequilibrium (LD) with multiple variants with regulatory features.ConclusionTaken together, the current study showed that an intron variant rs13340578, residing in CSMD1 gene, is associated with increased susceptibility to malaria. This finding suggests that modified regulation of complement may contribute to malaria disease severity. Further studies are needed to identify the causal variants and the underlying molecular mechanisms.