bluuebunny/crossref_metadata_2025_split huggingface dataset:
УДОСКОНАЛЕННЯ ОРГАНІЗАЦІЇ ОБЛІКУ ТА УПРАВЛІННЯ ЕКСПЛУАТАЦІЙНИМИ ВИТРАТАМИ НА ПІДПРИЄМСТВАХ ЗАЛІЗНИЧНОГО ТРАНСПОРТУ
Authors: Кірдіна О. Г. , Орлова В. М. , Гапусенко Ю. І. 
Published: May 2024

Облік експлуатаційних витрат залізничного транспорту повинен забезпечувати вирішення низки економічних проблем, що виникають у практичній діяльності підприємств залізничного транспорту, а саме: надавати високоякісні послуги з перевезення пасажів, вантажів, пошти та багажу за науково обґрунтованого рівня витрат з постійним збільшенням перевізних можливостей залізниць. У зв’язку з тим що облікова інформація в сучасних умовах стає головним орієнтиром ухвалення необхідних управлінських рішень, перед керівництвом Укрзалізниці виникла гостра необхідність трансформації традиційних підходів до обліку витрат, зокрема експлуатаційних. Раціональна організація управлінського обліку має безпосередній вплив на ефективність аналізу витрат в процесі управління підприємством, яка забезпечується глибоким розумінням суті витрат експлуатаційної діяльності і їх економічно обґрунтованою класифікацією.
INTERCONNECTION OF DIVERSIFICATION AND VALUE BASED MANAGEMENT IN SMALL WHOLESALE BUSINESS
Authors: Назаренко І. Л. , Лавринович І. С. , Скрипнік В. М. 
Published: May 2024

In the paper, we found out types of diversification suitable for small wholesale business in Ukraine in wartime. The most suitable types of diversification are: service, product, financial and geographic diversification. Also, horizontal, vertical, conglomerate and concentric types of diversification can be applied, taking into account their benefits and potential pitfalls defined in this paper.We also considered diversification as a value-creating strategy, outlined its main benefits and pitfalls. It offers several benefits, such as risk reduction by spreading investments across industries, thus reducing dependence on one market. It allows for synergies in related diversification through shared resources and expertise, enhancing efficiency and profitability. Additionally, diversification enables portfolio optimization, balancing performance across various sectors. However, it entails challenges like integration difficulties, potential overextension, and the risk of not realizing expected synergies. Effective diversification requires a clear strategic rationale, meticulous execution, and continuous monitoring, with willingness to divest from underperforming areas to sustain value creation.We suggested using Value Chain Analysis for choosing the most effective strategy of diversification for small wholesale business and developed Value Chain of a Small Wholesale Business (particularly, with heating equipment wholesale as a main type of activity).By understanding how each activity affects customer value, businesses can tailor their strategies to enhance customer satisfaction and loyalty. This might involve improving product quality, customer service, or any other activity directly impacting the customer experience.Value Chain Analysis is a strategic lens through which a business can view its activities and make informed decisions about where to focus its resources to maximize value creation.The next step of choosing the most effective value-creating strategy is building a Value Drivers Tree for each strategy considered and choosing the one creating the highest value of business.
ANALISIS PERTIMBANGAN MAHKAMAH AGUNG MENGABULKAN PERMOHONAN KASASI TERDAKWA DALAM PERKARA NARKOTIKA
Authors: Pratiwi Esti Alibi , Santoso Bambang 
Published: May 2024

<p>Artikel ini menganalisis hukum acara pidana mengenai pengajuan kasasi oleh terdakwa yang dikabulkan oleh MA dalam kasus narkotika. Hakim MA mengabulkannya karena hakim Pengadilan Tinggi yang menangani perkara ini dianggap telah salah dalam menerapkan hukum. Tujuan artikel ini adalah untuk membuktikan apakah pertimbangan Mahkamah Agung dalam mengabulkan permohonan terdakwa telah sesuai dengan Pasal 253 Ayat (1) KUHAP. Metode penelitian yang digunakan adalah penelitian hukum doktrinal atau normatif sehingga sifat penelitian ini adalah perskriptif dan terapan. Pengumpulan bahan hukum dengan cara studi kepustakaan kemudian bahan hukum yang digunakan yakni bahan hukum primer dan sekunder. Berdasarkan hasil penelitian dan pembahasan dari permasalahan tersebut dapat disimpulkan bahwa pertimbangan Mahkamah Agung mengabulkan permohonan kasasi terdakwa telah sesuai dengan ketentuan Pasal 253 Ayat (1) KUHAP karena fakta menunjukan telah terjadi kesalahan penerapan hukum dalam memutus perkara ini oleh hakim pengadilan sebelumnya</p><p> </p>
Proximity to Hospital-Based Obstetric Care in a Maternity Desert in the Deep South
Authors: James Jenna , Schultze Steven R. , Lee Alyssa , Perkins Allen , Daniel Casey L. 
Published: May 2024

Objectives. To examine the accessibility of hospital facilities with maternity care services in 1 rural county in Alabama in preparation for the initiation of prenatal care services at a federally qualified health center. Methods. We analyzed driving distance (in miles) from maternal city of residence in Conecuh County, Alabama to hospital of delivery, using 2019–2021 vital statistics data and geographic information system (GIS) software. Results. A total of 370 births to mothers who have home addresses in Conecuh County were reported, and 368 of those were in hospital facilities. The majority of deliveries were less than 30 miles (median = 23 miles) from the maternal city of residence. Some women traveled more than 70 miles for obstetrical care. Conclusions. Pregnant patients in Conecuh County experience significant geographic barriers related to perinatal care access. Using GIS for this analysis is a promising approach to better understand the unique challenges of pregnant individuals in this rural population. Public health policy efforts need to be geographically tailored to address these disparities. ( Am J Public Health. 2024;114(S4):S330–S333. https://doi.org/10.2105/AJPH.2024.307692 )
Phase composition and Durability Assessment of 50-year-old Reinforced Concrete subjected to Natural and Accelerated Carbonation
Authors: Dudi Lupesh , Bishnoi Shashank 
Published: May 2024

Abstract

This paper presents an investigation conducted on a 50-year-old structure in a composite climactic zone of India. The study comprises of two parts, one covering the comparison of long-term natural carbonation and short-term accelerated carbonation, while another reveals insight into the structure’s durability and potential concerns. Mineralogy, pore solution, and transport properties comparison of natural and accelerated carbonated concrete samples highlight similar modifications, demonstrating the representative nature of accelerated carbonation at 3% carbon dioxide concentration. Accelerated carbonation did, however, lead to preferred precipitation of calcite and higher degree of C-S-H carbonation. Additional investigations including core strength, carbonation depth measurements, half-cell potential analysis, resistivity, and corrosion rate measurements were also carried out. Findings from structural investigation indicate that carbonation coefficient shows a high variation within the structure and moisture is found to be main factor influencing the corrosion rate. Based on the results, recommendations on additional measurements are made, to better understand variations in carbonation rate. Visual inspections are seen to become crucial in the propagation phase, especially when half-cell potential and surface resistivity lie in the inconclusive range.
Mechanistic insight into Photocatalytic mineralization of dyes using metal oxide- Parametric and kinetic study
Authors: Singh Seema , Pratap Surya , Singh Santosh kumar , PATIDAR RITESH 
Published: May 2024

Abstract

In the present study, the photocatalytic degradation of Rhodamine-B dye was carried out. bismuth oxide (α − Bi2O3) and copper oxide (CuO) photo catalyst was prepared for the degradation analysis. During the photocatalysis of Rhodamine-B degradation, the order of removal with different semiconductors was followed in the following order: α − Bi2O3 > CuO. The effect of operating parameters, including solution pH (3–8), catalysts dose (0.2–1.5 g/L), temperature change (5–20 oC), and initial Rhodamine B dye concentration (10–25 mg/L), were systematically examined using α − Bi2O3 photocatalyst under UV-light irradiation. The Rhodamine-B dyes showed the best removal efficiency of 97% at operating conditions of natural pH = 7.0, catalyst dose = 1.5 g/L, temperature = 20 ◦C, and Rh-B concentration = 10 mg/L under control conditions. As − prepared semiconductor materials such as α − Bi2O3 and CuO were characterized by using many techniques like scanning electron microscope, energy dispersive X-ray, Fourier Transmission Infrared spectroscopy, and X − ray diffraction technique. A degradation pathway was also suggested by the identification of reaction intermediates. The reusability test analysis of bismuth oxide confirmed that photocatalysts can be separated after degradation and reused many times, and there were no other changes in structure and morphologies. This study confirmed the simple synthesis approach of semiconductor materials and their uses for the treatment of Rhodamine-B dye.
Undetected Cribriform and Intraductal Prostate Cancer at biopsy is associated with adverse outcomes
Authors: Bernardino Rui , Bernardino Rui , Bernardino Rui , Yin Leyi , Yin Leyi , Yin Leyi , Lajkosz Katherine , Lajkosz Katherine , Lajkosz Katherine , Cockburn Jessica , Cockburn Jessica , Cockburn Jessica , Wettstein Marian , Wettstein Marian , Wettstein Marian , Sayyid Rashid , Sayyid Rashid , Sayyid Rashid , Henrique Rui , Henrique Rui , Henrique Rui , Pinheiro Luís Campos , Pinheiro Luís Campos , Pinheiro Luís Campos , Kwast Theo van der , Kwast Theo van der , Kwast Theo van der , Fleshner Neil , Fleshner Neil , Fleshner Neil 
Published: May 2024

Abstract

Background
Intraductal carcinoma (IDC) and cribriform pattern (Crib) of prostate cancer are increasingly recognised as independent prognosticators of poor outcome, both in prostate biopsies and radical prostatectomy (RP) specimens.
Objective
The aim of our project is to assess the impact of false negative biopsies for these two characteristics on oncological outcomes.
Material and Methods
Patients who underwent RP between January 2015 and December 2022 were included in the study. Predictors of Biochemical Failure were examined using a multivariate Cox proportional hazards model.
Results and Limitation
Among the 836 patients who underwent RP, 233 (27.9%) had Crib, and 125 (15.0%) had IDC on prostate biopsy, with 71 (8.5%) patients having both IDC and Crib. Concerning, IDC/Crib status at biopsy, 217 (26%) patients had a false-negative biopsy, 332 (39.7%) had a true-negative biopsy, 256 (30.6%) showed a true-positive biopsy, and 24 (3.7%) exhibited a false-positive biopsy, with respect to either pattern. When comparing false-negative, false-positive, true-negative and true-positive biopsies for IDC/Crib, we found that patients with a false-negative biopsy for IDC/Crib versus those with a true-negative biopsy for IDC/Crib disclosed a rate of advanced pathological stage (≥ pT3) which was twice that of patients with a true-negative biopsy for IDC/Crib: 56.8% versus 28.1%, respectively (p < 0.001). On multivariate Cox analysis, log PSA before RP (hazard ratio [HR] 2.07, 95% CI 1.53–2.82; p < 0.001), a higher percentage of positive cores at biopsy (≥ 33%) (HR 1.68, 95% CI 1.07–2.63; p = 0.024), and false negative biopsy for IDC/Crib (HR 2.14, 95% CI 1.41–3.25; p < 0.001), were each significantly associated with an increased risk of BCR.
Conclusions
A false-negative biopsy for IDC/Crib is independently associated with higher risk of BCR and advanced pathological stage compared to a true negative biopsy.
A machine-learning pipeline for real-time detection of gravitational waves from compact binary coalescences
Authors: Marx Ethan , Benoit William , Gunny Alec , Omer Rafia , Chatterjee Deep , Venterea Ricco , Wills Lauren , Saleem Muhammed , Moreno Eric , Raikman Ryan , Govorkova Ekaterina , Rankin Dylan , Coughlin Michael , Harris Philip , Katsavounidis Erik 
Published: May 2024

Abstract

The promise of multi-messenger astronomy relies on the rapid detection of gravitational waves at very low latencies (O(1s)) in order to maximize the amount of time available for follow-up observations. In recent years, neural-networks have demonstrated robust non-linear modeling capabilities and millisecond-scale inference at a comparatively small computational footprint, making them an attractive family of algorithms in this context.
However, integration of these algorithms into the gravitational-wave astrophysics research ecosystem has proven non-trivial.
Here, we present the first fully machine learning-based pipeline for the detection of gravitational waves from compact binary coalescences (CBCs) running in low-latency. We demonstrate this pipeline to have a fraction of the latency of traditional matched filtering search pipelines while achieving state-of-the-art sensitivity to higher-mass stellar binary black holes.
Cathepsin S from spinal cord microglia accelerates the degradation of perineuronal nets in neuropathic pain
Authors: Pang Jiahui , Hu Ziwei , Zhao Yubai , Liu Xinli , Fang Qian , Xu Yin , Hu Yingxuan , Zeng Hui , Wu Wen 
Published: May 2024

Abstract

Neuropathic pain (NP) caused by nerve damage or diseases affects the quality of life of patients. Analyzing differentially expressed genes (DEGs) can help researchers focus on the key molecular in the diseases. This study aims to explore the relationship between Cathepsin S (CTSS) and perineuronal nets (PNNs). Dataset GSE18803 was used for bioinformatics analysis firstly. Next, the changes in CTSS and PNNs in the spinal cord of spared nerve injury (SNI) rats were detected. Then, LPS was used to activate HAPI cells, and detected the CTSS level of the cellular supernatant. Furthermore, the vitro PNNs degradation experimental by active CTSS was executed. Finally, CTSS inhibitors were injected intrathecally into SNI rats and observed the changes of mechanical pain and PNNs. In dataset GSE18803, 15 hub genes related were identified of the NP. Meanwhile, the mRNA and protein levels of CTSS were significantly upregulated, and the PNNs degradation in the ipsilateral spinal cord lamina V of SNI rats. In vitro, CTSS levels were upregulated in the LPS-activated HAPI cellular supernatant. Moreover, CTSS promoted the degradation of PNNs by the vitro experimental. Furthermore, intrathecal injection of CTSS inhibitor significantly improved the mechanical threshold of SNI rats and inhibited PNN degradation in the spinal cord lamina V of SNI rats. Bioinformatics analysis indicates that the lysosomal pathway is crucial for NP progression. The lysosomal protein CTSS is upregulated in the spinal cord of SNI rats. Microglia in the lamina V aggravates NP development by releasing CTSS to degrade PNNs in SNI rats.
Minimally Invasive Surfactant Therapy (MIST) vs intubate-surfactant-extubate (InSurE) technique, in a Peruvian Neonatal Intensive Care Unit (NICU)
Authors: Herbozo Cecilia , Montenegro Andrea , Zumba Karin 
Published: May 2024

Abstract

Objective To compare the outcomes of premature infants with respiratory distress syndrome treated by minimally invasive surfactant therapy (MIST) vs intubate-surfactant-extubate (InSurE) in a Level-3 NICU in Peru. Study Design: We analyzed a historical cohort with InSurE technique vs a prospective cohort with MIST. Surfactant was administered through a feeding tube in MIST cohort.Results 91 patients included, 48 treated by InSurE and 43 by MIST. Groups were similar in gestational age and birth weight, had poor prenatal care. There were no differences in demographic characteristics, nor in main outcomes: need for mechanical ventilation, bronchopulmonary dysplasia or mortality. The duration of mechanical ventilation, time of oxygen therapy and hospital stay were similar.Conclusions Our study shows that reduction of intubation for surfactant administration in preterm neonates with RDS can be achieved by MIST. No difference in outcomes between MIST and InSurE in preterm infants with RDS.
Application of GA3 and NAA improves yield and quality of Okra (Abelmoschus esculentus L.)
Authors: Abdullah Md , Anik Sultan Mahmud , Nishi Nusrat Jahan , Jahan Ishrat , khatun Mst Ananya , Rahman Md. Hassanur 
Published: May 2024

Abstract

In Bangladesh, okra is an important popular summer vegetable. However, traditional farming practices often lead to suboptimal yields. Thus, the study was designed to determine the ideal GA3 and NAA doses for accelerating okra growth, yield, and quality characteristics. A three-replication, randomized complete block design was adopted. Foliar sprays with three concentrations of GA3 (0 ppm, 150 ppm, and 250 ppm) and NAA (0 ppm, 150 ppm, and 250 ppm) were applied in 2022 and 2023. In comparison to the control, the combined application of GA3 @ 150 ppm and NAA @ 150 ppm improved plant height, leaf number, leaf area, branch number, internode length, bud number, pod number, pod length, pod diameter, and 1000 seed weight average over the two years. Furthermore, GA3 @ 150 ppm with NAA 150 ppm increased yield by 35.08% and 27.01% in 2022 and 2023 respectively, above the control. Combining NAA @ 150 ppm with GA3 resulted in higher levels of vitamin C, TSS, magnesium, and zinc by 19.31%, 81.2%, 22.73% and 21.43% in 2022 and 22.83%, 50.57%, 18.07%, 33.33% in 2023 respectively, compared to the control. In contrast, GA3 and NAA decreased potassium and calcium in both year when compared to the control. Overall, the results of this experiment indicated that using GA3 @ 150 ppm with NAA @ 150 ppm could enhance okra growth, yield, and quality. These findings provide insightful information for improving okra cultivation techniques and improving Bangladesh's productivity in agriculture and food security.
Development and internal validation of prediction model for rebleeding within one year after endoscopic treatment of cirrhotic varices: consideration from organ-based CT radiomics signature
Authors: Xu Lulu , Zhang Jing , Liu Siyun , He Guoyun , Shu Jian 
Published: May 2024

Abstract

Background
To develop CT radiomics model based on different organs to predict rebleeding within 1 year after endoscopic treatment of esophageal and gastric varices (EGVs). The aim is to guide clinicians to provide effective secondary prophylaxis to cirrhotic patients in a timely manner to prevent rebleeding.
Methods
123 patients were enrolled and divided into rebleeding (n = 44) and non-bleeding group (n = 79). The liver, spleen, and the lower part of the esophagus were segmented and the extracted radiomics features were selected to construct liver/spleen/esophagus radiomics signatures based on logistic regression. Clinic-radiomics combined models and multi-organ combined radiomics models were constructed based on independent model scores using logistic regression. The model performance was evaluated by ROC analysis, calibration and decision curves. The continuous net reclassification improvement (NRI) and integrated discrimination improvement (IDI) indices were analyzed .
Results
The clinical-liver combined model had the highest AUC of 0.931 (95% CI: 0.887–0.974), which was followed by the liver-based model with AUC of 0.891 (95% CI: 0.835–0.74). The decision curves also showed that the clinical-liver combined model afforded a greater net benefit compared to other models within the threshold probability of 0.45 to 0.80. Significant improvements in discrimination (IDI, P < 0.05) and reclassification (NRI, P < 0.05) were obtained for clinical-liver combined model compared with the independent ones.
Conclusion
The independent and combined liver-based CT radiomics models performed well in predicting rebleeding within 1 year after endoscopic treatment of EGVs.
Assessment of Acute and Multigenerational Toxicity of 1,3-Diphenylguanidine (DPG) on Freshwater Water Fleas: Oxidative Stress, Developmental, and Reproductive Effects
Authors: Suman Thodhal Yoganandham , Kim Soo-Yeon , Jang Younghoon , Jeon Junho 
Published: May 2024

Abstract

1,3-Diphenylguanidine (DPG) is intensively used in the tire manufacturing industry as an accelerator, improving durability of rubber product. Despite its widespread use, concerns persist regarding the potential environmental risks associated with toxicological properties and mechanisms of DPG, remaining inadequately understood. This study aims to comprehensively assess the acute and multigenerational toxicity of DPG on freshwater water fleas (Moina macrocopa). We verified the acute toxicity of DPG by subjecting water fleas to varying concentrations and establishing the no-observed effect concentration (NOEC) for subsequent chronic exposure experiments.. Across four generations (P0, F1, F2, and F3), water fleas were continuously exposed to a concentration lower than the NOEC to investigate reproductive and developmental toxicity alongside oxidative stress indicators, including reactive oxygen species (ROS), superoxide dismutase (SOD), catalase (CAT), glutathione disulfide (GSSG), and glutathione (GSH) activities. Multigeneration studies unveiled diminished reproduction rates, moulting, and body size across all exposed generations. Concurrently, heightened ROS levels coupled with decreased SOD, CAT, GSSG, and GSH activities signify the induction of antioxidant responses to DPG exposure. While reproductive effects were less pronounced in later generations, persistent oxidative stress across all generations underscores the necessity of multigenerational investigations in comprehending DPG's impact on water flea life cycles. This study underscores the necessity for additional research on DPG, promoting real-world exposure assessments and pragmatic experimental designs to precisely evaluate associated risks and implement sufficient environmental safeguards.
Investigating Load-Settlement Characteristics of Square Model Footings on Sand Beds Enhanced with Textured Vertical Pultruded Fiberglass Reinforced Helical Piles
Authors: Zargar Abdul Hanan Bashir , Shah Mohammad Yousuf 
Published: May 2024

Abstract

This article introduces a novel ground enhancement method utilizing textured vertically oriented fiberglass pultruded pipes. These pipes feature a widened bottom toe in a helical shape. The research primarily explores textured prefabricated helical piles, varying in length and cross-sectional area, designed to act as reinforcing bearing elements in sandy soil. The ongoing study includes performing experimental investigations on a laboratory model square footing positioned on sand, with textured PFRH piles installed beneath it. A parametric investigation was carried out to examine the influence of textured PFRH pile slenderness ratio, different states of sand beds, and varying helical plate diameters through laboratory model plate load tests. The findings indicated that placing textured PFRH piles beneath the footing substantially enhanced the settlement characteristics and load-carrying capacity of the structure. There was a noticeable increase in load-carrying capacity with an increase in the slenderness ratio of textured PFRH piles, although the improvement became insignificant beyond a slenderness ratio of 20. In the absence of reinforcement, denser sand exhibited superior bearing capacity for footings. However, in the case of reinforced footings, textured PFRH piles demonstrated the most substantial improvement in medium-density sand. Furthermore, augmenting the helical plate diameter led to an enhanced load-carrying capacity. The study employed multivariate linear regression to establish a robust correlation between experimental and predicted bearing capacity ratios, affirming the reliability of the findings. In summary, this research underscores the significant potential of utilizing textured prefabricated helical piles in fortifying soil foundations, offering valuable insights for optimizing the design and performance of such systems across diverse soil conditions.