bluuebunny/crossref_metadata_2025_split huggingface dataset:
An overview of fresh and mechanical properties of rubberized concrete
Authors: Saeed Najmadeen M. , Hassan Hogr Z. 
Published: May 2024

AbstractThe automotive industry's globalization and the widespread adoption of cars as primary transportation modes have spurred significant advancements in tire manufacturing. Consequently, a surplus of used tires has accumulated in recent years. Concurrently, there has been a shift towards evaluating tire life cycles and developing robust recycling and recovery programs. The potential for repurposing used tires as a valuable resource has become a critical consideration. In response to environmental concerns stemming from tire disposal, researchers have conducted numerous experiments exploring the effects of incorporating crushed rubber tires into concrete mixtures. These endeavors aim to enhance concrete properties while promoting sustainability through recycling. This burgeoning interest in "green concrete" production underscores the importance of investigating waste rubber's applications across various concrete types. This review provides a comprehensive analysis of waste rubber utilization in diverse concrete formulations. Drawing insights from 60 previous studies, the multifaceted impacts of rubber waste on concrete properties were elucidated. This investigation encompasses assessments of compressive strength, tensile strength, flexural strength, density, elastic modulus, and workability parameters through slump, V-funnel, and L-box tests. Through this synthesis, we contribute to a deeper understanding of the potential and limitations of incorporating waste rubber in concrete production, highlighting avenues for future research and practical implementation.
Spend it, save it, or transfer it?
Authors: Zhang Yanan , Guariglia Alessandra 
Published: May 2024

Abstract
We are the first to study how the resources freed up when a child, child-in-law, or grandchild moves out of a household are reallocated, taking into account the age of the leaver. Using the 2011 and 2013 waves of the China Health and Retirement Longitudinal Study, we document that, on average, the remaining household members save part of the resources freed up by the leaver and consume another part. Differentiating the leavers by age, we find that after the departure of a member of the younger generation aged 0–24, the remaining household members save the resources freed up by the leaver. However, if the leaver is above 24, they spend the freed-up resources. Our results are robust to the use of different specifications, estimation methods, and consumption aggregates. Finally, we observe that remittances directed toward non-resident offspring do not increase after the departure of a member of the younger generation.
‘Down pythons’ throats we thrust live goats’: snakes, zoos and animal welfare in nineteenth-century Britain
Authors: Cowie Helen 
Published: May 2024

Abstract
In nineteenth-century Britain, captive snakes in menageries and zoological gardens were routinely fed with live prey – primarily rabbits, pigeons and guinea pigs. From the late 1860s, this practice began to generate opposition on animal welfare grounds, leading to a protracted debate over its necessity, visibility and morality. Focusing on the c.1870–1914 period, when the snake-feeding controversy reached its zenith, this article charts changing attitudes towards the treatment of reptiles in captivity and asks why an apparently niche practice generated so much interest. By looking at the biological arguments put forward for and against live feeding, the article traces the changing nature of humanitarian activism in the late nineteenth century and shows how the shifting character of the live-feeding debate paralleled wider trends in the animal welfare movement. It also highlights the different types of knowledge and expertise involved in the debate, as naturalists, veterinary surgeons, legal professionals, zookeepers and humanitarians offered conflicting perspectives on questions of reptilian dietary requirements and animal sentience.
On the dual nature of creativity: Same same but different?
Authors: Benedek Mathias 
Published: May 2024

Abstract
The creativity literature is replete with dualistic constructs, suggesting shared mechanisms but also tempting overinterpretation of their interrelations. An explicit list of relevant concept associations indicates substantial commonality, yet also exposes certain inconsistencies. Dual-process accounts (A and B is relevant) hold promise in resolving discrepancies to the extent that we understand the relative contributions and conditions of A and B.
Novelty seeking is neither necessary nor sufficient for curiosity or creativity, instead both curiosity and creativity may reflect an epistemic drive
Authors: Holm Linus , Schrater Paul 
Published: May 2024

Abstract
Novelty is neither necessary nor sufficient to link curiosity and creativity as stated in the target article. We point out the article's logical shortcomings, outline preconditions that may link curiosity and creativity, and suggest that curiosity and creativity may be expressions of a common epistemic drive.
Toward a causal model of curiosity and creativity
Authors: Grüning David J. , Krueger Joachim I. 
Published: May 2024

Abstract
We extend Ivancovsky et al.'s finding on the association between curiosity and creativity by proposing a sequential causal model assuming that (a) curiosity determines the motivation to seek information and that (b) creativity constitutes a capacity to act on that motivation. This framework assumes that both high levels of curiosity and creativity are necessary for information-seeking behavior.
Mood regulation as a shared basis for creativity and curiosity
Authors: Zeitlen Daniel C. , Gasper Karen , Beaty Roger E. 
Published: May 2024

Abstract
We extend the work of Ivancovsky et al. by proposing that in addition to novelty seeking, mood regulation goals – including enhancing positive mood and repairing negative mood – motivate both creativity and curiosity. Additionally, we discuss how the effects of mood on state of mind are context-dependent (not fixed), and how such flexibility may impact creativity and curiosity.
The creativity of architects
Authors: Arbib Michael A. 
Published: May 2024

Abstract
TA builds on the state of mind (SoM) framework to offer the novelty-seeking model (NSM). The model relates curiosity to creativity but this commentary focuses on creativity: (i) It assesses the SoM + NSM model of creativity-in-the-lab, showing that the focus on semantic networks is inadequate. (ii) It discusses architectural design to sketch ideas for a theory of “big C” creativity.
Entscheiden unter Zeitdruck
Authors: Hahn Birgit , Gather Jakov , Sauter Dorothea 
Published: May 2024

Was ist zum Thema bereits bekannt? In Akutsituationen unter Zeitdruck ethische Entscheidungen zu treffen, ist herausfordernd. Wie wird eine neue Perspektive eingebracht? Es stehen verschiedene Ansätze zur Verfügung, die für die ethische Entscheidungsfindung in Akutsituationen hilfreich sein können. Was sind die Auswirkungen auf die Praxis? Psychiatrische Teams sollten sich strukturiert und vorausschauend mit der ethischen Entscheidungsfindung in Akutsituationen befassen und dabei auch das Vorher und das Nachher von Akutsituationen in den Blick nehmen. Dies kann sich sowohl für Nutzende als auch für Mitarbeitende psychiatrischer Institutionen entlastend auswirken und zu einer stärkeren Zufriedenheit führen.
Association of gastrointestinal microbiome and obesity with gestational diabetes mellitus-an updated globally based review of the high-quality literatures
Authors: Li Jiahui , Wang Min , Ma Shuai , Jin Zhong , Yin Haonan , Yang Shuli 
Published: May 2024

Abstract
Objectives
The purpose of this review is to investigate the relationship between gastrointestinal microbiome, obesity, and gestational diabetes mellitus (GDM) in an objective manner.

Methods
We conducted a thorough and comprehensive search of the English language literatures published in PubMed, Web of Science, and the Cochrane Library from the establishment of the library until 12 December 2023. Our search strategy included both keywords and free words searches, and we strictly applied inclusion and exclusion criteria. Meta-analyses and systematic reviews were prepared.

Results
Six high-quality literature sources were identified for meta-analysis. However, after detailed study and analysis, a certain degree of heterogeneity was found, and the credibility of the combined analysis results was limited. Therefore, descriptive analyses were conducted. The dysbiosis of intestinal microbiome, specifically the ratio of Firmicutes/Bacteroides, is a significant factor in the development of metabolic diseases such as obesity and gestational diabetes. Patients with intestinal dysbiosis and obesity are at a higher risk of developing GDM.

Conclusions
During pregnancy, gastrointestinal microbiome disorders and obesity may contribute to the development of GDM, with all three factors influencing each other. This finding could aid in the diagnosis and management of patients with GDM through further research on their gastrointestinal microbiome.
Foxo3 regulates cortical and medullary thymic epithelial cell homeostasis with implications in T cell development
Authors: Ribeiro Camila , Ferreirinha Pedro , Landry Jonathan J. M. , Macedo Fátima , Sousa Laura G. , Pinto Rute , Benes Vladimir , Alves Nuno L. 
Published: May 2024

AbstractWithin the thymus, thymic epithelial cells (TECs) create dedicated microenvironments for T cell development and selection. Considering that TECs are sensitive to distinct pathophysiological conditions, uncovering the molecular elements that coordinate their thymopoietic role has important fundamental and clinical implications. Particularly, medullary thymic epithelial cells (mTECs) play a crucial role in central tolerance. Our previous studies, along with others, suggest that mTECs depend on molecular factors linked to genome-protecting pathways, but the precise mechanisms underlying their function remain unknown. These observations led us to examine the role of Foxo3, as it is expressed in TECs and involved in DNA damage response. Our findings show that mice with TEC-specific deletion of Foxo3 (Foxo3cKO) displayed a disrupted mTEC compartment, with a more profound impact on the numbers of CCL21+ and thymic tuft mTEClo subsets. At the molecular level, Foxo3 controls distinct functional modules in the transcriptome of cTECs and mTECs under normal conditions, which includes the regulation of ribosomal biogenesis and DNA damage response, respectively. These changes in the TEC compartment resulted in a reduced total thymocyte cellularity and specific changes in regulatory T cell and iNKT cell development in the Foxo3cKO thymus. Lastly, the thymic defects observed in adulthood correlated with mild signs of altered peripheral immunotolerance in aged Foxo3cKO mice. Moreover, the deficiency in Foxo3 moderately aggravated the autoimmune predisposition observed in Aire-deficient mice. Our findings highlight the importance of Foxo3 in preserving the homeostasis of TECs and in supporting their role in T cell development and tolerance.
The new seriniquinone glycoside by biological transformation using the deep sea-derived bacterium Bacillus licheniformis KDM612
Authors: Okamura Ryota , Kikuchi Katsuki , Taniguchi Akito , Nagai Kenichiro , Seki Reiko , Ohte Satoshi , Ohshiro Taichi , Ando Masashi , Tanaka Teruyoshi , Fukuda Takashi 
Published: May 2024

AbstractSeriniquinone was isolated as a melanoma-selective anti-cancer agent from a culture broth of the marine-derived bacterium Serinicoccus marinus CNJ927 in 2014. It targets the unique small protein, dermcidin, which affects the drug resistance of cancer cells. Due to its significant activity against cancer cells, particularly melanoma, and its unique target, seriniquinone has been developed as a new pharmacophore. However, it has the disadvantage of poor solubility in drug discovery research, which needs to be resolved. A new seriniquinone glycoside (1) was synthesized by the biological transformation of seriniquinone using the deep sea-derived bacterium Bacillus licheniformis KDM612. Compound 1 exhibited selective anti-cancer activity against melanoma, similar to seriniquinone, and was 50-fold more soluble in DMSO than seriniquinone.
Self-organization of modular activity in immature cortical networks
Authors: Mulholland Haleigh N. , Kaschube Matthias , Smith Gordon B. 
Published: May 2024

AbstractDuring development, cortical activity is organized into distributed modular patterns that are a precursor of the mature columnar functional architecture. Theoretically, such structured neural activity can emerge dynamically from local synaptic interactions through a recurrent network with effective local excitation with lateral inhibition (LE/LI) connectivity. Utilizing simultaneous widefield calcium imaging and optogenetics in juvenile ferret cortex prior to eye opening, we directly test several critical predictions of an LE/LI mechanism. We show that cortical networks transform uniform stimulations into diverse modular patterns exhibiting a characteristic spatial wavelength. Moreover, patterned optogenetic stimulation matching this wavelength selectively biases evoked activity patterns, while stimulation with varying wavelengths transforms activity towards this characteristic wavelength, revealing a dynamic compromise between input drive and the network’s intrinsic tendency to organize activity. Furthermore, the structure of early spontaneous cortical activity – which is reflected in the developing representations of visual orientation – strongly overlaps that of uniform opto-evoked activity, suggesting a common underlying mechanism as a basis for the formation of orderly columnar maps underlying sensory representations in the brain.
Graded decisions in the human brain
Authors: Xie Tao , Adamek Markus , Cho Hohyun , Adamo Matthew A. , Ritaccio Anthony L. , Willie Jon T. , Brunner Peter , Kubanek Jan 
Published: May 2024

AbstractDecision-makers objectively commit to a definitive choice, yet at the subjective level, human decisions appear to be associated with a degree of uncertainty. Whether decisions are definitive (i.e., concluding in all-or-none choices), or whether the underlying representations are graded, remains unclear. To answer this question, we recorded intracranial neural signals directly from the brain while human subjects made perceptual decisions. The recordings revealed that broadband gamma activity reflecting each individual’s decision-making process, ramped up gradually while being graded by the accumulated decision evidence. Crucially, this grading effect persisted throughout the decision process without ever reaching a definite bound at the time of choice. This effect was most prominent in the parietal cortex, a brain region traditionally implicated in decision-making. These results provide neural evidence for a graded decision process in humans and an analog framework for flexible choice behavior.
Highly reversible zinc metal anode enabled by strong Brønsted acid and hydrophobic interfacial chemistry
Authors: Nian Qingshun , Luo Xuan , Ruan Digen , Li Yecheng , Xiong Bing-Qing , Cui Zhuangzhuang , Wang Zihong , Dong Qi , Fan Jiajia , Jiang Jinyu , Ma Jun , Ma Zhihao , Wang Dazhuang , Ren Xiaodi 
Published: May 2024

AbstractUncontrollable zinc (Zn) plating and hydrogen evolution greatly undermine Zn anode reversibility. Previous electrolyte designs focus on suppressing H2O reactivity, however, the accumulation of alkaline byproducts during battery calendar aging and cycling still deteriorates the battery performance. Here, we present a direct strategy to tackle such problems using a strong Brønsted acid, bis(trifluoromethanesulfonyl)imide (HTFSI), as the electrolyte additive. This approach reformulates battery interfacial chemistry on both electrodes, suppresses continuous corrosion reactions and promotes uniform Zn deposition. The enrichment of hydrophobic TFSI– anions at the Zn|electrolyte interface creates an H2O-deficient micro-environment, thus inhibiting Zn corrosion reactions and inducing a ZnS-rich interphase. This highly acidic electrolyte demonstrates high Zn plating/stripping Coulombic efficiency up to 99.7% at 1 mA cm–2 ( > 99.8% under higher current density and areal capacity). Additionally, Zn | |ZnV6O9 full cells exhibit a high capacity retention of 76.8% after 2000 cycles.
In vivo neutralization of coral snake venoms with an oligoclonal nanobody mixture in a murine challenge model
Authors: Benard-Valle Melisa , Wouters Yessica , Ljungars Anne , Nguyen Giang Thi Tuyet , Ahmadi Shirin , Ebersole Tasja Wainani , Dahl Camilla Holst , Guadarrama-Martínez Alid , Jeppesen Frederikke , Eriksen Helena , Rodríguez-Barrera Gibran , Boddum Kim , Jenkins Timothy Patrick , Bjørn Sara Petersen , Schoffelen Sanne , Voldborg Bjørn Gunnar , Alagón Alejandro , Laustsen Andreas Hougaard 
Published: May 2024

AbstractOligoclonal mixtures of broadly-neutralizing antibodies can neutralize complex compositions of similar and dissimilar antigens, making them versatile tools for the treatment of e.g., infectious diseases and animal envenomations. However, these biotherapeutics are complicated to develop due to their complex nature. In this work, we describe the application of various strategies for the discovery of cross-neutralizing nanobodies against key toxins in coral snake venoms using phage display technology. We prepare two oligoclonal mixtures of nanobodies and demonstrate their ability to neutralize the lethality induced by two North American coral snake venoms in mice, while individual nanobodies fail to do so. We thus show that an oligoclonal mixture of nanobodies can neutralize the lethality of venoms where the clinical syndrome is caused by more than one toxin family in a murine challenge model. The approaches described may find utility for the development of advanced biotherapeutics against snakebite envenomation and other pathologies where multi-epitope targeting is beneficial.
Observation of unusual outer-sphere mechanism using simple alkenes as nucleophiles in allylation chemistry
Authors: Zeng Yaxin , Gao Han , Jiang Zhong-Tao , Zhu Yulei , Chen Jinqi , Zhang Han , Lu Gang , Xia Ying 
Published: May 2024

AbstractTransition-metal catalyzed allylic substitution reactions of alkenes are among the most efficient methods for synthesizing diene compounds, driven by the inherent preference for an inner-sphere mechanism. Here, we present a demonstration of an outer-sphere mechanism in Rh-catalyzed allylic substitution reaction of simple alkenes usinggem-difluorinated cyclopropanes as allyl surrogates. This unconventional mechanism offers an opportunity for the fluorine recycling ofgem-difluorinated cyclopropanes via C − F bond cleavage/reformation, ultimately delivering allylic carbofluorination products. The developed method tolerates a wide range of simple alkenes, providing access to secondary, tertiary fluorides andgem-difluorides with 100% atom economy. DFT calculations reveal that the C − C bond formation goes through an unusual outer-sphere nucleophilic substitution of the alkenes to the allyl-Rh species instead of migration insertion, and the generated carbon cation then forms the C − F bond with tetrafluoroborate as a fluoride shuttle.
Integrative multi-region molecular profiling of primary prostate cancer in men with synchronous lymph node metastasis
Authors: Singhal Udit , Nallandhighal Srinivas , Tosoian Jeffrey J. , Hu Kevin , Pham Trinh M. , Stangl-Kremser Judith , Liu Chia-Jen , Karim Razeen , Plouffe Komal R. , Morgan Todd M. , Cieslik Marcin , Lucianò Roberta , Shariat Shahrokh F. , Finocchio Nadia , Dambrosio Lucia , Doglioni Claudio , Chinnaiyan Arul M. , Tomlins Scott A. , Briganti Alberto , Palapattu Ganesh S. , Udager Aaron M. , Salami Simpa S. 
Published: May 2024

AbstractLocalized prostate cancer is frequently composed of multiple spatially distinct tumors with significant inter- and intra-tumoral molecular heterogeneity. This genomic diversity gives rise to many competing clones that may drive the biological trajectory of the disease. Previous large-scale sequencing efforts have focused on the evolutionary process in metastatic prostate cancer, revealing a potential clonal progression to castration resistance. However, the clonal origin of synchronous lymph node (LN) metastases in primary disease is still unknown. Here, we perform multi-region, targeted next generation sequencing and construct phylogenetic trees in men with prostate cancer with synchronous LN metastasis to better define the pathologic and molecular features of primary disease most likely to spread to the LNs. Collectively, we demonstrate that a combination of histopathologic and molecular factors, including tumor grade, presence of extra-prostatic extension, cellular morphology, and oncogenic genomic alterations are associated with synchronous LN metastasis.
Heliorhodopsin-mediated light-modulation of ABC transporter
Authors: Cho Shin-Gyu , Kim Ji-Hyun , Lee Ji-eun , Choi In-Jung , Song Myungchul , Chuon Kimleng , Shim Jin-gon , Kang Kun-Wook , Jung Kwang-Hwan 
Published: May 2024

AbstractHeliorhodopsins (HeRs) have been hypothesized to have widespread functions. Recently, the functions for few HeRs have been revealed; however, the hypothetical functions remain largely unknown. Herein, we investigate light-modulation of heterodimeric multidrug resistance ATP-binding cassette transporters (OmrDE) mediated by Omithinimicrobium cerasi HeR. In this study, we classifiy genes flanking the HeR-encoding genes and identify highly conservative residues for protein–protein interactions. Our results reveal that the interaction between OcHeR and OmrDE shows positive cooperatively sequential binding through thermodynamic parameters. Moreover, light-induced OcHeR upregulates OmrDE drug transportation. Hence, the binding may be crucial to drug resistance in O. cerasi as it survives in a drug-containing habitat. Overall, we unveil a function of HeR as regulatory rhodopsin for multidrug resistance. Our findings suggest potential applications in optogenetic technology.
Prodrug-conjugated tumor-seeking commensals for targeted cancer therapy
Authors: Shen Haosheng , Zhang Changyu , Li Shengjie , Liang Yuanmei , Lee Li Ting , Aggarwal Nikhil , Wun Kwok Soon , Liu Jing , Nadarajan Saravanan Prabhu , Weng Cheng , Ling Hua , Tay Joshua K. , Wang De Yun , Yao Shao Q. , Hwang In Young , Lee Yung Seng , Chang Matthew Wook 
Published: May 2024

AbstractProdrugs have been explored as an alternative to conventional chemotherapy; however, their target specificity remains limited. The tumor microenvironment harbors a range of microorganisms that potentially serve as tumor-targeting vectors for delivering prodrugs. In this study, we harness bacteria-cancer interactions native to the tumor microbiome to achieve high target specificity for prodrug delivery. We identify an oral commensal strain of Lactobacillus plantarum with an intrinsic cancer-binding mechanism and engineer the strain to enable the surface loading of anticancer prodrugs, with nasopharyngeal carcinoma (NPC) as a model cancer. The engineered commensals show specific binding to NPC via OppA-mediated recognition of surface heparan sulfate, and the loaded prodrugs are activated by tumor-associated biosignals to release SN-38, a chemotherapy compound, near NPC. In vitro experiments demonstrate that the prodrug-loaded microbes significantly increase the potency of SN-38 against NPC cell lines, up to 10-fold. In a mouse xenograft model, intravenous injection of the engineered L. plantarum leads to bacterial colonization in NPC tumors and a 67% inhibition in tumor growth, enhancing the efficacy of SN-38 by 54%.