bluuebunny/crossref_metadata_2025_split huggingface dataset:
No effect of CYP450 and P‐glycoprotein on hydroxyurea in vitro metabolism
Authors: Sassi Hind , Bachir Dora , Habibi Anoosha , Astier Alain , Galactéros Frédéric , Hulin Anne 
Published: October 2009

AbstractOur objectives were (1) to study the HU metabolism via human cytochromes and (2) to test if HU is a substrate of P‐gp. HU metabolism was investigated by determining the appearance of urea and HU decreasing upon incubation with human liver microsomes. Quantification was determined using HPLC coupled with UV‐detection at 449 nm. Our method was linear between 5 and 1000 μm, precise (coefficients of variation ranging from 1.7 to 9.9%), accurate (97.7–103.9%). The limit of quantification was 7 μm. The ATPase activity of human P‐gp membranes was determined by measuring inorganic phosphate liberation. HU and urea measurements in microsomes were not different between 0 and 60 min whatever HU concentration used from 30 to 300 μm. The presence of NADPH in the medium has no effect on HU and urea measurements. In the absence of verapamil, the ATPase activity was unaffected by HU at concentrations of 10, 30, 100 and 300 μm. HU is unlikely to cause clinically relevant drug interactions with the substrates of these enzymes/transporters. However, it will be necessary to validate these in vitro data in patients with sickle cell anemia to evaluate the impact of genetic polymorphisms of these enzymes in a black population.
The ultrastructural and biochemical evidences of the beneficial effects of chronic caffeic acid phenethyl ester and melatonin administration on brain and cerebellum of aged rats
Authors: Eşrefoğlu Mukaddes , Gül Mehmet , Ateş Burhan , Yılmaz İsmet 
Published: October 2009

AbstractNervous system is highly vulnerable to the deleterious effects of age‐related oxidative stress. A large body of researches has consistently confirmed the implication of free radicals both in normal cerebral ageing and ageing‐related pathologies. In the present study, in addition to the light and electron microscopic pictures of brain and cerebellum of young, old and antioxidant administered old Sprague–Dawley rats, pro‐oxidant status was evaluated in terms of measurements of total glutathione, lipid peroxidation (malondialdehyde) and activities of superoxide dismutase, catalase and glutathione peroxidase. Taking the results together, we suggest that supplemental administration of caffeic acid phenethyl ester and melatonin is beneficial in delaying age‐related cellular damage in nervous system.
The Cost‐Effectiveness of Postal and Telephone Methodologies in Increasing Routine Outcome Measurement Response Rates in CAMHS
Authors: Horn Rachel , Jones Steve , Warren Kate 
Published: October 2009

Background:  This small evaluation compared the cost effectiveness of different methods of questionnaire administration (General system improvements, postal reminders and telephone reminders) sent as part of the CORC protocol employed by three community CAMHS teams.Method:  Return rates and costs of these different methods were recorded and compared with a 3‐month baseline (during which questionnaires were distributed using existing systems) and following 3‐month intervention period.Results:  Comparison of return rates between baseline and intervention periods indicated that administrative improvements and a centralised mailing process increased the return rate of questionnaires by 11%. A further limited increase of 16% was achieved when a postal reminder was added, whilst an additional telephone reminder significantly increased the return rate by 34%. Telephone administration and telephone follow‐up to initial postal administration is more expensive overall than postal methods alone; however, the cost per return is substantially less. An initial postal mailing plus telephone reminder is predicted to provide services with more representative data on service effectiveness and acceptability than postal methods alone.Conclusions:  The findings of this small scale project are useful in informing the Routine Outcome Measurement (ROM) administration protocol and highlight the importance of resourcing ROM and increasing the quality of the data collected.
Molecular cloning and expression of pheromone‐binding protein1 from the diamondback moth, Plutella xylostella
Authors: Zhang Zhi‐Chun , Wang Man‐Qun , Zhang Guoan 
Published: October 2009

AbstractWe report on the identification and characterization of a new cDNA encoding the pheromone‐binding protein1 (PxylPBP1) from male antennae of the diamondback moth, Plutella xylostella (L.) (Lepidoptera: Plutellidae). The deduced amino acid sequences of PxylPBP1 revealed a mature protein of 164 amino acids, with six cysteine residues in conserved positions relative to other known PBP. The alignment of the mature PxylPBP1 with other Lepidoptera PBP showed high sequence similarity (70–80%) with other full‐length sequences from GenBank. Reverse transcription polymerase chain reaction (PCR) analysis revealed that the PxylPBP1 gene is only expressed in antennae. Real‐time PCR further indicated that the expression of PxylPBP1 gene is higher in male moths, and higher in mated moths regardless of gender. The transcription levels of PxylPBP1 gene of unmated male moths reduced with age, and peaked in 4‐h‐old female moths.
Crocidolomia pavonana larval foraging: behavior and feeding site preferences on cabbage, Brassica oleracea
Authors: Takeuchi Hiroaki , Zalucki Myron P. , Furlong Michael J. 
Published: October 2009

AbstractExperiments were conducted to determine feeding site preferences of Crocidolomia pavonana (Fabricius) (Lepidoptera: Crambidae) larvae within cabbage plants, Brassica oleracea L. var. capitata cv. Warrior (Brassicaceae), and to determine whether induced plant responses to herbivory affect the behavior of larvae. In the first experiment, intra‐plant damage and larval distribution were recorded to account for the spreading pattern of damage and larval feeding behavior on a plant; larvae initially fed on the base of leaves and moved progressively to the bud, leaf tips were avoided. In the second experiment, larval performance (the duration of the first instar, survival to the second instar, and weight of second instars) was assessed when larvae fed on the bud, the base, and the tip of the youngest fully expanded leaf on a plant. Crocidolomia pavonana larvae performed best when they fed on bud leaf tissue and most poorly when they fed on leaf tissue at the base of leaves. In the third experiment, expression of induced resistance was tested on each of the three plant parts using a first‐instar bioassay. Negative impacts on larval growth and development were not detected when larvae fed on the bud or base tissue when plants were damaged prior to the assay. However, negative effects were detected in larvae feeding on tip leaf tissue when the base of the leaf was damaged prior to the assay or if the bud tissue was damaged simultaneously with the assay. The findings indicate that resource heterogeneity for C. pavonana within‐cabbage plants is determined by both the initial quality of food at a location and by subsequent induced changes as a result of larval feeding; both contribute to the feeding pattern observed in these gregarious larvae.
Attraction of Trialeurodes vaporariorum and Bemisia argentifolii to eggplant, and its potential as a trap crop for whitefly management on greenhouse poinsettia
Authors: Lee Doo‐Hyung , Nyrop Jan P. , Sanderson John P. 
Published: October 2009

AbstractTrap cropping, though promising, has had little evaluation in greenhouses. This study evaluated eggplant, Solanum melongena L. (Solanaceae), as a trap crop for two whitefly species, Trialeurodes vaporariorum (Westwood) and Bemisia argentifolii Bellows & Perring (both Hemiptera: Aleyrodidae), on greenhouse poinsettia, Euphorbia pulcherrima Willd. ex Koltz (Euphorbiaceae). Because the two whitefly species co‐occur in greenhouses, a common trap crop for both whiteflies is desirable. When adults were provided a choice between eggplant and poinsettia in a cage, 60% of B. argentifolii and 98% of T. vaporariorum were observed on eggplant after 3 days. However, when adults were given eggplant after first settling on poinsettia, only 38% of B. argentifolii were later found on eggplant, whereas 95% of T. vaporariorum moved to eggplant. In a greenhouse experiment, eggplant did not affect either the spatial distribution or density of adult B. argentifolii on poinsettias. In contrast, eggplant changed the spatial distribution of T. vaporariorum within 3 days by attracting and retaining the adults. However, the attractiveness of eggplant did not result in a reduced number of T. vaporariorum on poinsettias compared with poinsettias in monoculture. Adult T. vaporariorum mortality was high on poinsettias and this likely caused adult density on poinsettias in monoculture to decrease as fast as that under trap cropping. A simulation model was developed to examine how adult whitefly mortality on poinsettia influences trap cropping effectiveness. When whitefly mortality was high, simulated densities were similar to the experimental data. This reveals an unexpected factor, pest mortality on the main crop, that can influence the relative effectiveness of trap cropping. Our results indicate that eggplant will not work unilaterally as a trap crop for B. argentifolii. For T. vaporariorum, attraction to eggplant might be useful as a trap crop system when whitefly mortality on the main crop is not high.
CD30 positive anaplastic large‐cell lymphoma mimicking Langerhans cell histiocytosis
Authors: Ezra Navid , Van Dyke Gregory S. , Binder Scott W. 
Published: October 2009

The presence of CD 1a+ dendritic cells (DC) has been well described in T‐cell lymphoproliferative disorders, and the presence of large numbers of DCs has rarely been reported as a mimicker of Langerhans cell histiocytsis (LCH). We present the case of a 56‐year‐old female with a solitary nodule on the chin whose case was referred to our institution for confirmation of the diagnosis of LCH. Skin biopsy showed an ulcerated nodule containing a wedge‐shaped infiltrate comprised of large atypical cells and cells with prominent grooved nuclei. The constellation of histologic and immunologic features favored a CD30 lymphoproliferative disorder of T‐cell lineage even though there were accompanying numerous dendritic histiocytes and CD1a positive Langerhans cells. The sheets of CD30 positive atypical lymphoid cells which express T‐cell markers were consistent with CD30 positive lymphoproliferative disease and favor CD30 positive anaplastic large‐cell lymphoma (ALCL) over Langerhans histiocytosis. The absence of Anaplastic Lymphoma Kinase (ALK) staining favored a primary cutaneous origin. This case signifies a CD 30+ ALCL of the skin which histopathologically mimics a LCH.Ezra N, Van Dyke GS, Binder SW. CD30 positive anaplastic large‐cell lymphoma (ALCL) mimicking Langerhans cell histiocytosis (LCH).
Proliferative nodules in a giant congenital melanocytic nevus–case report and review of the literature
Authors: Van Houten Annemarie H. , Van Dijk Marcory C. R. F. , Schuttelaar Marie‐Louise A. 
Published: October 2009

Malignant transformation of giant congenital nevi (GCN) is very rare, but may already occur in childhood. Benign proliferative nodules in GCN may clinically and histologically mimic a malignant melanoma. We report a newborn infant with large proliferative nodules and multiple satellite nevi in a GCN of the bathing suit type. The diagnosis in our patient was based on the smooth transition of the pre‐existing lesion and the nodule, the absence of strong atypical nuclei, the atypical mitotic figures, the ascension of melanocytes in the epidermis and the absence of necrosis. A review of the literature showed that the clinical and the histological features of benign (proliferative) nodules are variable. The awareness and the identification of this entity by clinicians and pathologist are imperative to prevent diagnostic errors.van Houten AH, van Dijk MCRF, Schuttelaar MLA. Proliferative nodules in a giant congenital melanocytic nevus–case report and review of the literature.
Three years after the publication of the German (S3) evidence based Psoriasis Guidelines – Was it worth the effort?
Authors: Nast Alexander , Rzany Berthold 
Published: October 2009

SummaryThe S3 (evidence‐based) psoriasis guidelines were an important milestone in German dermatology. Three years after their publication, a review and evaluation of their success is important. Since the publication of the guidelines, the quality of care of psoriasis patients has improved. The proportion of patients with a PASI above 20 in the general patient population has decreased, there are less days of work lost due to psoriasis, uncertainties in administering systemic therapies have been decreased and the proportion of patients with severe psoriasis receiving a systemic treatment has increased. The guidelines’ website as well as the original publication in the JDDG has been accessed more than 50,000 times. The guidelines’ discussion was continued even after its publication and in further publications from within the group a therapeutic algorithm, treatment goals and indicators for the quality of care have been developed.
The Travels of Naturalism and the Challenges of a World Literary History
Authors: Hill Christopher L. 
Published: October 2009

AbstractThe history of the naturalist novel reveals shortcomings of recent proposals for the study of world literature, such as those of Franco Moretti and Pascale Casanova. After a naturalist esthetic coalesced in France in the 1860s naturalist schools appeared around the world. Contrary to what models of diffusion predict, naturalism flourished in distant parts of the world at the same time as its triumph in Europe, while writers nearer France rejected it. The examples of naturalism in Argentina, Brazil, Japan, China, and Korea, reveal multiple, overlapping histories that make up the heterogeneous planetary history of the form. Naturalism’s movement was aided by its association with non‐fictional genres such as criminology, and flourished where other forms of realistic fiction were not well established. Even when naturalism bore the standard for realism, however, it formed unexpected alliances with other esthetics and shifted its associations with non‐fictional genres. Rather than focusing on the origination and reception of forms such as the naturalist novel, studies of world literature should focus on the conditions of travel through which such unexpected transformations occur.
Implementation of the School Nurse Practitioner Role: Barriers and Facilitators
Authors: McKaig Charlene , Hindi‐Alexander Michele , Myers Theresa R. , Castiglia Patricia 
Published: October 2009

ABSTRACTThe purpose of this descriptive pilot study was to begin an exploration of the role determinants that facilitate or cause barriers to the implementation of the school nurse practitioner (SNP) role. Utilizing a two‐step design, 16 SNPs from different school districts were surveyed to determine if their assignment included doing school physical exams. Thirteen indicated that they were functioning as SNPs. The three “no” districts were matched with three of the “yes” districts. An SNP, a school health administrator and a school physician from each district were interviewed individually using a structured questionnaire. The focus of the questions was on organizational structure of the school health services, indicators of administrative support for SNPs and the assigned function of the SNP. Responses were matched for the “yes” and “no” districts and for the three types of professionals. The major facilitator of SNP role implementation was if the idea had originated with the administrator or physician decision maker. Role change and boundary encroachment were the main barriers identified.
Children's Literature in the School Health Education Program
Authors: Manna Anthony L. 
Published: October 2009

ABSTRACTChildren's literature covers a wide range of topics, themes and issues that can help children in the elementary school health education program develop an awareness of personal and public health. A model for selecting and evaluating fictional stories and informational books that deal with topics included in the health education curriculum, giving particular attention to book selections that treat nutrition and environmental issues, is presented in this paper.
Maximizing School Health Services in a time of Fiscal Restraint
Authors: Gottlieb Nell H. , Kotch Jamie B. 
Published: October 2009

ABSTRACTThis case study reports a communitywide effort to reduce the fragmentation and duplication of child health services in Boston. Consensus was first reached on what basic health services should be offered and where — school or community — they would be most efficiently and effectively delivered. The planning group then developed strategies to coordinate a network for the delivery of these services. Implementation has begun. The Boston experience offers a mechanism to maximize school health services as available funding for them declines.
Theoretical Perspectives of Holistic Health
Authors: Cmich Dianne E. 
Published: October 2009

ABSTRACTThe purpose of this investigation was to identify the fundamental theories of holism and holistic health. Two objectives of this study were: 1) to review selected Western 20th Century writings during the time period of 1925–1979 which reflected the concepts of holistic thought; and 2) to synthesize the basic principles of holistic thought from the literature.Four principles of holism and 12 components of holistic health were identified from a variety of fields of study. These 16 concepts represent the key ideas of holistic thought.An overview of holism and holistic health was presented followed by a discussion of each concept of holistic thought. The relationship of these concepts to health education was also briefly explored.
Catheterization — A Health Procedure Schools Must Be Prepared to Provide
Authors: Stauffer Donald T. 
Published: October 2009

ABSTRACTClean, intermittent catheterization is a simple procedure to allow people with spina bifida, paraplegia and quadriplegia to empty their bladder. The courts have ruled that it must be provided to students who require it as a related service under Public Law 94–142.
STD Content in School Health Textbooks: An Evaluation Using the Worth Assessment Procedure
Authors: Kroger Fred , Yarber William L. 
Published: October 2009

ABSTRACTClassroom education is a key strategy to controlling sexually transmitted diseases in young persons. Textbooks are the major or sole source of STD information for many students. Thirteen secondary level health science textbooks and five sex education textbooks were reviewed to assess their potential contribution to STD control objectives. Worth assessment, a decision analysis tool for helping decision makers choose among complex or maltiattributed alternatives, was used to evaluate the STD content. The review indicated that sex education textbooks are more likely to contribute to STD control objectives than are health science textbooks. Health science textbooks failed to incorporate information on preventive health behaviors. Both types of textbooks present biomedical information primarily, which is generally free of significant errors. The worth assessment method proved to be a useful tool for evaluating the quality of textbook treatment in a specific content area.
Comprehensive Health Screening in Elementary Schools: An Outcome Evaluation
Authors: Brink Susan G. , Nader Philip R. 
Published: October 2009

ABSTRACTA health screening program, piloted in 14 school districts in Texas from 1977 to 1979, was evaluated to determine the outcome of the screenings. Outcome measures used were the number of completed referrals, the number of conditions judged by health care providers not to exist and the number of problems of potential educational significance identified. While several problems were detected, the high rate of false positives and low referral completion reported from community health care providers leads to questions concerning the effectiveness of comprehensive health screening in the schools. However, the emphasis placed on identification during the screening of children with educationally significant problems may enable the schools to better serve these children. Referral follow‐up in the community and schools to address identified problems would assure that the expenditure of funds for screening would not be futile.
Resolving Nonmedical Obstacles to Successful School Reentry for Children with Cancer
Authors: Ross Judith W. 
Published: October 2009

ABSTRACTAn annual seminar for school personnel of elementary school‐aged pediatric center patients is described. Facilitating understanding of the educational and social needs of such patients, providing updated information about childhood malignancy and addressing the concerns of teachers, nurses and others is warranted because of the many patients who will be cured and who must be prepared to enter adulthood.
Defining Health: A Multidimensional Model*
Authors: Eberst Richard M. 
Published: October 2009

ABSTRACTThe purpose of this article is to describe a new conceptual model of holistic health. The model employs an extremely popular toy that makes it very accessible to both young children and adults. Factors that affect health status and the role of personal behavior are also discussed. Specific recommendations for members of the school health team are presented.
The Views of School Principals and Teachers on the Role of the School Nurse with Handicapped Students
Authors: Goodwin Laura D. , Keefe Maureen R. 
Published: October 2009

ABSTRACTAs part of recent program evaluation activities for the University of Colorado School Nurse Achievement Program, a questionnaire was distributed to a sample of school principals and teachers to obtain their views on the role of the school nurse with handicapped students. Generally, the respondents perceived this aspect of the school nurse's role as encompassing a variety of valuable activities; they tended to feel that certain activities (eg, writing the health component of the IEPs) should be carried out by school nurses more than they actually are; and they reported a myriad of unsolved problems and needs of handicapped students, many that could be dealt with by school nursing services if resources were available. Although the data were obtained from only a small and select group of principals and teachers, they help reveal how other school personnel view this increasingly important component of the school nurse's role and may provide some direction for future continuing education programs for school nurses as well as information‐dissemination efforts for other school personnel.
Students' Knowledge of Child Health and Development: Effects on Approaches to Discipline
Authors: Showers Jacy , Johnson Charles Felzen 
Published: October 2009

ABSTRACTUnrealistic developmental and behavioral expectations of children, which are associated with child abuse, are related to a lack of knowledge about child development and child rearing. The Iowa Child Development Test (ICDT) was administered to college students to determine their knowledge of child health and development and effects on disciplinary approaches. The results indicated that college students had inadequate knowledge and those who most frequently chose harsh disciplinary methods in simulated child management situations were least knowledgeable. This finding is similar to that reported in an earlier study of high school seniors. College men knew less than college women about child development and health, and more frequently selected harsh punishment. Although noneducation and education majors did not differ with regard to level of knowledge on the ICDT, noneducation majors more frequently chose punish and abuse responses. The findings suggest a need to provide broad‐based programs in child rearing education prior to parenthood to reduce the potentiating effects of inadequate knowledge of child health and development on the incidence of child abuse.