bluuebunny/crossref_metadata_2025_split huggingface dataset:
Massive pediatric neurosurgical injuries and lessons learned following a tornado disaster in Alabama
Authors: Chern Joshua J. , Miller Joseph H. , Tubbs R. Shane , Whisenhunt Thomas R. , Johnston James M. , Wellons John C. , Rozzelle Curtis J. , Blount Jeffrey P. , Oakes W. Jerry 
Published: December 2011

Object
A large volume of patients presented to a Level I pediatric trauma center during and after a recent tornado disaster. Injuries of the central and peripheral nervous systems and the medical responses of a pediatric neurosurgical team are reviewed.

Methods
The clinical courses of patients who suffered cranial, spinal, and peripheral nerve injuries due to the tornado storm are reported. The clinical actions taken by the neurosurgical team during and after the event are reviewed and the lessons learned are discussed.

Results
The tornado storm system moved through the Tuscaloosa and Birmingham metropolitan areas on the early evening hours of April 27, 2011. Twenty-four patients received care from the neurosurgical team. A total of 11 cranial (including placement of an external ventricular drain), 2 spine, and 2 peripheral procedures were performed for the victims. Nine procedures were performed within the first 12 hours of the event, and an additional 6 surgeries were performed in the following 24 hours. Injuries of the peripheral nervous system often presented in a delayed fashion. Several key components were identified that enabled adequate neurosurgical care for a large influx of acute patients.

Conclusions
Massive casualties due to tornados are rare. A well-organized physician team working with the hospital administration may decrease the mortality and morbidity of such events.
Correlation among magnetic resonance imaging findings, prognostic factors for survival, and histological diagnosis of intrinsic brainstem lesions in children
Authors: Dellaretti Marcos , Touzet Gustavo , Reyns Nicolas , Dubois François , Gusmão Sebastião , Pereira Júlio Leonardo Barbosa , Blond Serge 
Published: December 2011

Object
The aim of this study was to compare MR imaging characteristics with histopathological findings of intrinsic brainstem lesions and also to show the prognostic factors in patients with diffuse brainstem glioma.

Methods
Between February 1988 and August 2007, 44 brainstem biopsies were performed at the Roger Salengro Hospital in Lille, France, in children with intrinsic brainstem lesions not amenable to excision. Twenty-six were female and 18 male, and the mean age was 6 years.

Results
Histological evaluation revealed diffuse brainstem glioma in all patients with diffuse nonenhancing brainstem lesions. Diffuse brainstem glioma was found in 18 patients (90%) with diffuse enhancing brainstem lesions. Pathological entities different from diffuse glioma were verified in 2 patients (10%)—1 with ependymoma and 1 with ganglioglioma.
In 4 of 5 patients with a focal nonenhancing brainstem lesion, the histopathological diagnosis was diffuse low-grade glioma. In 6 of 10 patients with focal enhancing brainstem lesion, the diagnosis was diffuse brainstem glioma, and pathological entities different from diffuse brainstem glioma were verified in 2 (20%), both with pilocytic astrocytoma.
The mean 1-year actuarial survival rates for patients classified with low-grade and high-grade glioma were 80.4% ± 0.08% and 48.6% ± 0.14%, respectively.

Conclusions
The impact of stereotactic biopsy on intrinsic brainstem lesions was greater in patients with MR imaging–documented enhancing lesions in whom the diagnosis of diffuse glioma was less frequent. Patients with low-grade glioma seem to have longer survival than those with high-grade glioma.
L'implantation néolithique en Bretagne centrale
Authors: Le Roux Charles Tanguy 
Published: December 2011

Since the discovery, in 1964, of the stone-axe factory working the «dolérite du type A» at Plussulien, in the south-west of Department des Côtes du Nord, excavations and surveys concerned not only megalithic graves at Laniscat and Plenauff, but also dwelling places at St-Nicolas-du-Pélem and Trémargat.
A consistent vision begins to émerge from this, concerning the neolithisation of that part of central Brittany (chronology, links with the «classical» coastal areas, cultural affinities, territorial organisation, demography). Some of these data can even give a basis for trial extrapolation, to western France in general.
La sépulture à entrée latérale de Beaumont en Saint-Laurent-sur-Oust
Authors: Tinévez Jean-Yves 
Published: December 2011

Threatened by replantation after a forest fire and in the past used as a quarry, the megalithic monument of Beaumont at Saint-Laurent-sur-Oust (Morbihan) is interesting from an architectural and artifactural point of view. Despite the absence of the capstones and some of the uprights, the monument belongs to the "sépulture à entrée latérale" group comprising a rectilineal burial chamber oriented east west with an entry situated at the eastern end of the south side. At the western end a small independant chamber is situated. An oval stone cairn covers the monument, two to three courses of the outer dry stone walling surviving.
The artefacts comprise several vessels of the Quessoy style (round bottomed bowls and flat bottomed carenated bowls), a shird with vertical decoration of the Kerugou style, a lithic assemblage comprised essentially of flint blades, polished axes, sandstone flakes and several elements of dress ornament. The artifacts enable us to date the monument to the final neolithic.
The soil fill of the tomb contained fragments of calcinated human bone. The interest of the monument is further increased by its position on a natural promontory dominating the Oust valley and by the presence of a possible habitation site.
Les mégalithes de Saint-Just (Ille-et-Vilaine) et la fouille des alignements du Moulin de Cojou
Authors: Le Roux Charles Tanguy , Lecerf Yannick , Gautier Maurice 
Published: December 2011

A rescue dig, on a part of the Cojou megalithic alignments at Saint-Just (Ille-et-Vilaine, Brittany, France), showed a long and complex fréquentation of the site. It began by a series of large hearths dated between 4940 and 4100 B.C. The standing stones were erected at least in two phases separated by the building of a stone «causeway», itself partly covered by a mound which yelded remains of beakers of spécial interest and a large Early Bronze Age urn, dated 2780-2180 B.C.
This excavation provided also the opportunity of a general survey of the megaliths of this parish, which revealed severely damaged by comparison with the old descriptions.
Une fosse néolithique au lieu-dit Le Boisanne à Plouer-sur-Rance (Côtes d'Armor)
Authors: Tinévez Jean-Yves , Cornec Thierry , Pihuit Patrick 
Published: December 2011

During road construction at Le Boisanne, near Plouer-sur-Rance, the discovery of a pottery was followed by the excavation of a neolithic pit.
Narrowand deep, this isolated pit was larger on its east side, A level of charcoal in the top of filling has produced a carbon 14 date. The pottery has some affinities with the Cerny Group. The hypothesis of a grave can be suggested.
Poses - Le Vivier - Le Clos-Saint-Quentin (Eure). L'occupation de la plaine inondable au Néolithique et au début de l'Age du Bronze
Authors: Billard Cyrille , Aubry Bruno , Blancquaert Geertrui , Bourhis Jean-Roger , Habasque Gilles , Marinval Philippe , Pinel Carole , Ropars Anne , Lebret Patrick , Lefèbvre Dominique , Marguerie Dominique , Paulet-Locard Marie-Armelle 
Published: December 2011

From 1989 to 1991, a rescue-dig took place at Poses, «Le Vivier- Le Clos-Saint-Quentin». The area studied
is situated on the flood-plain, which explains in this place important alluvial deposits, and consequently exceptionnal conservation of neolithic and chalcolithic seulement levels.
On four hectares, the excavation has induced the study of seven settlements and also secondary areas (particularly combustion structures of polynesian type and accumulation of blocks of sandstone). The two oldest settlements belong to the «post-rubané» cultures (Villeneuve-Saint-Germain, Cerny) and the five others to the chalcolithic cultures.
The most important resuit concerns, on one hand, the first neolithisation of the country and, on the other hand, the development of a chrono-cultural framework for the Late Neolithic - Early Bronze Age transition. The excavations have shown the existence of original late neolithic features (assemblages 3 and 4), have confirmed the large impact of Bell Beakers espansion in a late time in the Lower Valley of the Seine River and their evolution (assemblages 5 and 6), and finally have allowed to discover an unknown chalcolithic feature (assemblage 7).
This operation enables us also to approach the theme of the development of marginal lands in areas liable to flooding.
Le paléoenvironnement de la région de Carnac. Sondage dans le marais de Kerdual, La Trinité-sur-Mer (Morbihan)
Authors: Visset Lionel , Sellier Dominique , L'Helgouach Jean 
Published: December 2011

Large stone monuments testify to the presence of a large human population in the Carnac region during
the 5th and 4th millenia. Core samples were obtained from sediments of a former filled-in bay enclosed between interfluves on which several funeral constructions exist. These dimentology and palynology revealed by these samples were the basis for a first attempt at reconstituing the landscape and paleoenvironment before, during and after the neolithic occupation.
The results show that the deposits at this site do not go back any earlier than the early Bronze Age. Resumption of the marine transgression between 3400 and 3000 BP seems to have contributed to the formation of a sait meadowat the beginning of the armorican subatlantic period.
Cereals were present during the Bronze Age and were developed more extensively during Gallo-Roman times.
Chestnut and walnut pollens were apparent starting at the base of the diagram, which poses a problem concerning
the date and processes by which these plants were introduced into the Massif Armoricain.
Où sont passés les Mésolithiques côtiers bretons? Bilan 1985-1995 des prospections de surface dans le Finistère
Authors: Gouletquer Pierre , Kayser Olivier , Le Goffic Michel , Léopold Pierre , Marchand Grégor , Moullec Jean-Michel 
Published: December 2011

Since 10 years, the development of field-walking prospecting in the department àf Finistère gives more and more sites of the middle and late Mesolithic periods and the idea of « costal Mesolithic » is contested. The main sites, which are recognized through density and nature of artefacts seem to settle on a line situated at about 20 km from the present coast. The neighbourhood of materials concurrencing flint seems to be determinant in this localization. Those materials are excellent tracers of populations movements, either to the interior, or to the sea- side, and permit to draw migratory saisonal deplacements.
During the late Mesolithic, using the ultramylonite of Mikaël, and the calcedoines of Le Clos, the ensemble of Mikaël-Le Clos is a good example of such a territory. It is precisely bounded and one can trace the echelonnement of flaking operations during the deplacements.
Social Influences, Social Norms, Social Support, and Smoking Behavior among Adolescent Workers
Authors: Fagan Pebbles , Eisenberg Marla , Stoddard Anne M. , Frazier Lindsay , Sorensen Glorian 
Published: December 2011

Purpose. To examine the relationships between worksite interpersonal influences and smoking and quitting behavior among adolescent workers. Design. The cross-sectional survey assessed factors influencing tobacco use behavior. Setting. During the fall of 1998, data were collected from 10 grocery stores in Massachusetts that were owned and managed by the same company. Subjects. Eligible participants included 474 working adolescents ages 15 to 18. Eighty-three percent of workers (n = 379) completed the survey. Measures. The self-report questionnaire assessed social influences, social norms, social support, friendship networks, stage of smoking and quitting behavior, employment patterns, and demographic factors. Results. Thirty-five percent of respondents were never smokers, 21% experimental, 5% occasional, 18% regular, and 23% former smokers. Using analysis of variance (ANOVA), results indicate that regular smokers were 30% more likely than experimental or occasional smokers to report coworker encouragement to quit (p = .0002). Compared with regular smokers, never smokers were 15% more likely to report greater nonacceptability of smoking (p = .01). χ2 tests of association revealed no differences in friendship networks by stage of smoking. Conclusions. These data provide evidence for the need to further explore social factors inside and outside the work environment that influence smoking and quitting behavior among working teens. Interpretations of the data are limited because of cross-sectional and self-report data collection methods used in one segment of the retail sector.
Usefulness of Serum Anti-p53 Antibody Assay for Lung Cancer Diagnosis
Authors: Park Yongjung , Kim Yoonjung , Lee Jong-Han , Lee Eun Young , Kim Hyon-Suk 
Published: December 2011

Context.—Some tumor markers, including carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (CYFRA 21-1), are used for the detection of lung cancer; however, their use is limited because of low sensitivities and high false-positive rates.
Objectives.—To investigate the usefulness of an anti-p53 assay in detecting lung cancer and to compare the anti-p53 to CEA and CYFRA 21-1 tumor markers.
Design.—Serum samples were collected from 82 patients with lung cancer. Sera were also collected from 79 patients with or without benign pulmonary disease for the control group. All 161 specimens were assayed for CEA, CYFRA 21-1, and anti-p53. The diagnostic performances of these markers were compared using receiver operating characteristic analysis.
Results.—The receiver operating characteristic area under the curve values of CYFRA 21-1, CEA, and anti-p53 for discriminating lung cancers from benign or healthy conditions were 0.79, 0.81, and 0.79, respectively. Area under the curve for the 3 markers in combination was 0.90. The sensitivities of those markers for lung cancer detection were respectively 39.0%, 53.7%, and 34.1% at 94.9% specificity, and the cutoff levels at those sensitivities and specificities were 4.5 ng/mL for CYFRA 21-1, 5.4 ng/mL for CEA, and 2.7 U/mL for anti-p53. We found 79.3% positive results for patients with lung cancer by any of the 3 markers, and 12.2% were positive only for anti-p53. All patients without cancer had negative results for 2 or all 3 markers.
Conclusions.—Anti-p53 combined with other conventional markers is helpful in increasing the sensitivity and specificity for detecting lung cancer.
Live‐Cell Immunofluorescence Staining of Human Pluripotent Stem Cells
Authors: Manos Philip D. , Ratanasirintrawoot Sutheera , Loewer Sabine , Daley George Q. , Schlaeger Thorsten M. 
Published: December 2011

AbstractAntibodies are instrumental tools in stem cell identification, purification, and analysis. Most commonly, cell samples are either dissociated to obtain a single‐cell suspension suitable for FACS analysis or cell sorting, or fixed in situ for immunostaining and fluorescence microscopy imaging. This unit describes an alternative method in which live adherent cells are stained and imaged in situ without the need for cell dissociation, fixation, or fluorescent reporter genes. This minimally invasive method is particularly useful for identification and distinction of fully and partially reprogrammed induced pluripotent stem cells (iPSCs). The unit also describes the use of mCD49e and hCD29 antibodies in live‐cell (vital) imaging. mCD49e strongly stains mouse embryonic fibroblast (MEF) feeder cells in human pluripotent stem cell cultures, whereas hCD29 recognizes an antigen expressed on undifferentiated and many differentiated cells. A distinguishing feature of hCD29 in live‐cell staining is that its antigen is precluded from detection wherever cells have formed tight epithelial junctions (e.g., in the center but not the periphery of pluripotent stem cell colonies) due to basolateral location. A non‐fluorescent fixed‐cell staining protocol is also provided for medium‐ to high‐throughput quantification of stem cell experiments without an automated microscope. The discussion addresses technical limitations, pitfalls, troubleshooting, and potential applications, such as identification of emerging bona fide human iPSC colonies in reprogramming experiments. Curr. Protoc. Stem Cell Biol. 19:1C.12.1‐1C.12.14. © 2011 by John Wiley & Sons, Inc.
Organotypic Explant Culture of Glioblastoma Multiforme and Subsequent Single‐Cell Suspension
Authors: Shimizu Fumiko , Hovinga Koos E. , Metzner Michael , Soulet Denis , Tabar Viviane 
Published: December 2011

AbstractGlioblastoma multiforme (GBM) is one of the most aggressive brain tumors. GBM cell lines used in laboratory studies are frequently passaged in various culture media at high proliferation rates, resulting in significant genetic and molecular alterations. Thus, data obtained in cell lines are often inapplicable to patient tumors. Furthermore, recent studies suggest that there is a stem cell–like hierarchy among GBM cell populations and a crucial role for tumor vasculature in stem cells, as well as tumor growth, which cannot be reproduced in cell line cultures. Our laboratory has developed a novel three‐dimensional (3D) organotypic “explant” system of surgical GBM specimens that preserves tumor cells in their original milieu, as well as the cytoarchitecture of the tumor stroma. Our previous study on the role of Notch inhibition has demonstrated a definitive effect on the tumor endothelium that could only be highlighted by this system. In this unit, we describe a detailed protocol for preparing GBM explants, and discuss strengths, as well as limitations of the explant system as an in vitro 3D model of GBM. Curr. Protoc. Stem Cell Biol. 19:3.5.1‐3.5.9. © 2011 by John Wiley & Sons, Inc.
Safeguarding the Needs of Children and Young People Seeking Asylum in the UK: Addressing Past Failings and Meeting Future Challenges
Authors: Hek Rachel , Hughes Nathan , Ozman Roberto 
Published: December 2011

Numerous reviews of UK policy and practice have criticised the provision of support to children and young people seeking asylum. Recent research and policy analysis present a dual failure in the current response: that of the immigration system in recognising and responding to specific needs; and that of statutory services in applying key legislation relating to rights, entitlements and subsequent provision. In combination, this illustrates a system that is at all times in tension between ideas of control and protection of these vulnerable young people, and ultimately therefore fails to safeguard.‘A system that is at all times in tension between ideas of control and protection’Recent changes to government policy, the legislative framework and practice guidance governing such provision suggest that such failings may have been recognised but much work remains to be done to implement these changes effectively. Furthermore, these changes are occurring in a period of significant instability in public service provision, resulting from the severe cuts to public funding outlined in the UK Government's 2010 Comprehensive Spending Review (HM Treasury, 2010). It is therefore timely to review current policy and practice related to children and young people seeking asylum in the UK so as to address past failings and fully realise the stated commitment to ensure a young person's ‘best interests’ are fully considered in any immigration decision. Copyright © 2012 John Wiley & Sons, Ltd.Key Practitioner Messages

Refugee and asylum seeking children's welfare should be the primary focus of practice rather than immigration policy.
Provision of safe, suitable accommodation, appropriate education, emotional support and leisure activities are key to children's wellbeing.
Refugee and asylum seeking children in families tend to receive even less services than unaccompanied children.
Practitioners should ensure that where possible they work with the whole family and the wider community to provide appropriate services.‘Refugee and asylum seeking children's welfare should be the primary focus of practice rather than immigration policy’
Amplatzer septal occluder to treat iatrogenic cardiac perforations
Authors: Stolt Valérie , Cook Stéphane , Räber Lorenz , Wani Sunil , Garachamani Ali , Vogel Rolf , Seiler Christian , Windecker Stephan , Meier Bernhard 
Published: December 2011

AbstractBackground: Iatrogenic free wall cardiac perforation is a rare but serious complication encountered during percutaneous cardiac procedures, which usually leads to tamponade and death. Septal occluder devices have been developed for sealing intracardiac shunts but may be also used in this emergency setting. Methods and Results: We report a small series of five consecutive cases of iatrogenic heart perforations that were treated with implantation of Amplatzer Septal Occluders (ASO). In the first case, iatrogenic left ventricle (LV) perforation occurred during LV biopsy and could be closed up with a 4 mm ASO. In the second case, a 4 mm ASO was used for sealing of a right atrial perforation allocated to Port‐a‐Cath dislodgment. The third case happened during transseptal puncture for implantation of a TandemHeart bVAD device in a patient suffering cardiogenic shock and was treated by implantation of a 5 mm ASO. The fourth patient was transferred to our facilities for percutaneous closure of an acute post‐infarct VSD after anteroseptal myocardial infarction. This procedure was complicated by perforation of the posterolateral free wall and led to the deployment of 12 mm ASO. The last patient suffered from free LV wall perforation during investigation of a severe aortic stenosis and was treated by implantation of 4 mm ASO. All patients were alive after 24 hrs but the last patient died during the in‐hospital stay of a right ventricular infarction complicated by multiple organ failure. Conclusions: Percutaneous device occlusion of iatrogenic heart perforation seems to be a safe and efficient method to treat iatrogenic heart perforation. In order to perform this elegant method, it is however imperative not to prematurely withdraw the perforating catheter to maintain access to the hole for closure. © 2011 Wiley Periodicals, Inc.
ChemInform Abstract: The Crystal Structure of Yb2(SO4)3·3H2O and Its Decomposition Product, β‐Yb2(SO4)3.
Authors: Mills Stuart J. , Petricek Vaclav , Kampf Anthony R. , Herbst‐Imer Regine , Raudsepp Mati 
Published: December 2011

AbstractYb2(SO4)3·3H2O (I) is hydrothermally synthesized from an aqueous mixture of Yb2O3 and H2SO4 (autoclave, 220 °C, 400 h).
ChemInform Abstract: Morphology‐Controlled Synthesis and Efficient Photocatalytic Performances of a New Promising Photocatalyst Sr0.25H1.5Ta2O6 ·H2O.
Authors: Liang Shijing , Shen Lijuan , Zhu Jia , Zhang Yongfan , Wang Xuxu , Li Zhaohui , Wu Ling , Fu Xianzhi 
Published: December 2011

AbstractThe title photocatalyst with high surface area is hydrothermally prepared from mixtures of Ta2O5·nH2O Sr(NO3)2, NaOH, and H2O (autoclave, 200 °C).
ChemInform Abstract: Nickel‐Catalyzed Amination of Aryl Carbamates and Sequential Site‐Selective Cross‐Couplings.
Authors: Mesganaw Tehetena , Silberstein Amanda L. , Ramgren Stephen D. , Nathel Noah F. Fine , Hong Xin , Liu Peng , Garg Neil K. 
Published: December 2011

AbstractThe method is broad in scope with respect to both coupling partners.
ChemInform Abstract: Diazo‐Transfer Reactions to 1,3‐Dicarbonyl Compounds with Tosyl Azide.
Authors: Presset Marc , Mailhol Damien , Coquerel Yoann , Rodriguez Jean 
Published: December 2011

AbstractMultigram‐scale synthesis of 2‐diazo‐1,3‐dicarbonyl compounds can be efficiently performed.