bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Supported Copper Hydroxide on Titanium Oxide as an Efficient Reusable Heterogeneous Catalyst for 1,3‐Dipolar Cycloaddition of Organic Azides to Terminal Alkynes
Authors: Yamaguchi Kazuya , Oishi Takamichi , Katayama Tatsuyori , Mizuno Noritaka 
Published: August 2009

AbstractAn easily prepared supported copper hydroxide on titanium oxide (Cu(OH)x/TiO2) showed high catalytic performance for the 1,3‐dipolar cycloaddition of organic azides to terminal alkynes in non‐polar solvents under anaerobic conditions. The reactions of various combinations of organic azides (four examples, including aromatic and aliphatic ones) and terminal alkynes (eleven examples, including aromatic, aliphatic, and double bond‐containing ones) exclusively proceeded to give the corresponding 1,4‐disubstituted‐1,2,3‐triazole derivatives in a completely regioselective manner. For the transformation of benzyl azide and ethynylbenzene with 0.12 mol % of Cu(OH)x/TiO2, the turnover frequency was 505 h−1 and the turnover number reached up to 800. These values were the highest among those with previously reported heterogeneous catalysts including Cu(OH)x/Al2O3. The observed catalysis was truly heterogeneous and the retrieved catalyst after the reaction could be reused at least three times with retention of its high catalytic performance. It was confirmed by the UV/Vis spectrum of Cu(OH)x/TiO2 and the amount of diyne formed that the CuII species in Cu(OH)x/TiO2 were reduced to CuI species by the alkyne–alkyne homocoupling at the initial stage of the reaction (during the pretreatment of Cu(OH)x/TiO2 with an alkyne). The catalytic reaction rate for the 1,3‐dipolar cycloaddition linearly increased with an increase in the amount of in situ generated CuI species. Therefore, the in situ generated CuI species would be the catalytically active species for the present 1,3‐dipolar cycloaddition.
Infinite energy solutions to the homogeneous Boltzmann equation
Authors: Cannone Marco , Karch Grzegorz 
Published: August 2009

AbstractThe goal of this work is to present an approach to the homogeneous Boltzmann equation for Maxwellian molecules with a physical collision kernel that allows us to construct unique solutions to the initial value problem in a space of probability measures defined via the Fourier transform. In that space, the second moment of a measure is not assumed to be finite, so infinite energy solutions are not a priori excluded from our considerations. Moreover, we study the large‐time asymptotics of solutions and, in a particular case, we give an elementary proof of the asymptotic stability of self‐similar solutions obtained by A. V. Bobylev and C. Cercignani [J. Stat. Phys. 106 (2002), 1039–1071]. © 2009 Wiley Periodicals, Inc.
Planar Source Line‐of‐Sight Model with Automatically Adjusting Time Increment and Local Sticking Factors
Authors: Jilesen Jonathan , Lien Fue‐Sang 
Published: August 2009

AbstractA simple feature‐scale model is developed to simulate the low pressure (LP)CVD process. The direct deposition for this model is modeled as arriving from a source plane. A line‐of‐sight model and cylindrical co‐ordinates are used to form an analytical equation to describe the direct flux of particles arriving from the source plane. The use of a source plane allows for easier linking in multiscale simulations through the use of effective reactivity maps. A method of automatically adjusting the time increment to decrease the number of time steps required to accurately simulate the deposition process is also introduced.
Cyclosporine Therapeutic Monitoring With CMAX in Kidney Transplant Recipients: Impact of Schistosomal Infection
Authors: El‐Agroudy Amgad E. , Ismail Amani M. , Nassar Mohamed , Ghoneim Mohamed A. 
Published: August 2009

AbstractBACKGROUNDThe aim of the study was to assess whether the C2 level is a good parameter to predict a drug's maximal concentration (CMAX) values in Egyptian kidney transplant recipients (KTR).METHODSA total of 50 stable KTRs with a previously confirmed diagnosis of schistosomal infection compared to KTRs (n = 50) without schistosomal infection regarding cyclosporine (CsA) concentrations at time 0 (trough), 1.5, 2, 2.5, 3, and 3.5 hours post‐CsA. The statistical significance of linear regression between different CsA time concentrations and drug dosages was calculated.RESULTSPatients in the schistosomal group had significantly lower C2 levels (511 ± 118 ng/mL) compared with the control group (669 ± 213 ng/mL; p < 0.05), whereas the C2.5 level was significantly higher (730 ± 215 and 527 ± 129 ng/mL, respectively; p < 0.05). Only C2.5 in the schistosomal group had a significant linear regression relationship with both morning CsA dose and CsA dose expressed as mg/kg/d (p = 0.0123, r = 0.573018).CONCLUSIONSEgyptian patients have special characteristics in drug absorption and metabolism, mostly due to schistosomal infection, and they may need the use of C2.5 for monitoring of CsA. If confirmed by subsequently larger studies, these findings may have a significant impact on our management of CsA immunosuppression in clinical renal transplantation in certain ethnicities.
Successful Treatment of Recurrent Wegener's Granulomatosis in a Transplanted Kidney with Rituximab, Plasmapheresis, and Steroids
Authors: Dalal Pranav , Shah Gaurav , Tripathi Shreyank , Patel Nilang 
Published: August 2009

AbstractWegener's granulomatosis can recur in a transplanted kidney. We present a case of treatment wtih rituximab of recurrent Wegener's granulomatosis in a transplanted kidney.
The Effect of Low Calcium Dialysate on Calcium‐Phosphate Metabolism and Its Correlation With Other Coefficient Factors in CAPD
Authors: Sun Jing , Wang Rong , Yu Kezhou , Wang Qun , Wang Xining 
Published: August 2009

AbstractOBJECTIVEIt has been suggested that low calcium concentration dialysate could be used in the treatment of continuous ambulatory peritoneal dialysis (CAPD) patients with renal osteodystrophy. This study aims to investigate the effect and safety of low calcium concentration dialysate (1.25 mmol/L) compared with high calcium concentration dialysate (1.75 mmol/L) in treating CAPD‐caused renal osteodystrophy, and the correlation between clinical parameters and the serum calcium level in CAPD patients.METHODSThe study was performed on 57 clinically stable CAPD patients with hypercalcemia. All patients were randomized to switch to 1.25 mmol/L calcium dialysate (group A) or continue on 1.75 mmol/L calcium dialysate (group B) for a period of 48 weeks. Biochemical data was evaluated at 0, 4, 8, 12, 16, 32, and 48 weeks. The clinical manifestations were recorded.RESULTSA total of 53 patients completed the study. After 48 weeks of observation there was no difference in the level of blood albumin, volume of dialysate, and ultrafiltration (p > .05). After 8 weeks, the level of serum calcium, as well as phosphate and magnesium, showed a significant decrease in the patients of group A (p < .05). Comparison between the 2 groups showed an increase in serum parathyroid hormone (PTH) level in group A (p < .05). But the biochemical data was no different in group B. The intake of calcium carbonate increased significantly in group A after 8 weeks (p < .05). The decrease percentage index of calcium showed a negative correlation with age and a positive correlation with volume of dialysis.CONCLUSIONSThe administration of 1.25 mmol/L calcium dialysate may benefit abnormal calcium‐phosphate metabolism and decrease suppression of parathyroid hormone in CAPD patients with adynamic bone diseases. Individualization should be noticed with low calcium dialysate.
Visualizing canonical Wnt signaling during mouse craniofacial development
Authors: Mani Preethi , Jarrell Andrew , Myers John , Atit Radhika 
Published: August 2009

AbstractWnt signaling is critical for proper development of the head and face in the mouse embryo, playing important roles in various aspects of craniofacial development ranging from axis formation to survival of cranial neural crest cells to patterning of the brain. The signaling requirements for the development of different cell lineages in the head and face are active areas of investigation. In this study, we use a recently developed TCF/Lef‐LacZ transgenic reporter mouse to characterize the expression of canonical Wnt signaling activity during craniofacial development. We present an atlas of representative sections to show embryonic craniofacial development. Our results demonstrate a pattern of sustained Wnt signaling reporter activity in most tissues which suggests sequential roles in craniofacial development. Developmental Dynamics 239:354–363, 2010. © 2009 Wiley‐Liss, Inc.
The measure of a man: Associations between digit ratio and disordered eating in males
Authors: Smith April R. , Hawkeswood Sean E. , Joiner Thomas E. 
Published: August 2009

AbstractObjectiveThe current study sought to determine whether there is a relationship between prenatal testosterone exposure, as indicated by the digit ratios of the second to fourth fingers (2D:4D ratio), and disordered eating and drive for muscularity in men.MethodDigit ratios were calculated by measuring photocopies of participants' finger lengths. Self‐reported body image and eating attitudes and behaviors were assessed.ResultsThere were significant correlations between 2D:4D ratio and disordered eating and drive for leanness, indicating that greater prenatal testosterone exposure was associated with less disordered eating and increased drive for muscularity.DiscussionThis suggests that greater prenatal testosterone exposure may be protective factor against the development of eating disorders in men. Potential mechanisms are discussed. © 2009 by Wiley Periodicals, Inc. Int J Eat Disord 2010; 43:543–548
Narcissistic characteristics and eating‐disordered behaviors
Authors: Campbell Mari , Waller Glenn 
Published: August 2009

AbstractObjectiveThere is evidence that core narcissism and the narcissistic defenses have a role in the emotions and cognitions associated with the eating disorders. However, there is little understanding of its relationship with behaviors seen in this population. This study aimed to examine the relationship between narcissism and eating‐disordered behaviors (e.g., bingeing and purging).MethodThe participants, 110 women presenting with an eating disorder, completed measures of narcissism and eating disorder psychopathology.ResultsAssociations were found between patients who engaged in excessive exercise and levels of narcissism. There were also dimensional associations between eating‐disordered behaviors and specific aspects of narcissism.DiscussionClinical implications and limitations of the study are discussed, and future directions for research suggested. © 2009 by Wiley Periodicals, Inc. Int J Eat Disord 2010; 43:560–564
Mobile therapy: Use of text‐messaging in the treatment of bulimia nervosa
Authors: Shapiro Jennifer R. , Bauer Stephanie , Andrews Ellen , Pisetsky Emily , Bulik‐Sullivan Brendan , Hamer Robert M. , Bulik Cynthia M. 
Published: August 2009

AbstractObjectiveTo examine a text‐messaging program for self‐monitoring symptoms of bulimia nervosa (BN) within the context of cognitive‐behavioral therapy (CBT).MethodThirty‐one women participated in 12 weekly group CBT sessions and a 12 week follow‐up. Participants submitted a text message nightly indicating the number of binge eating and purging episodes and rating their urges to binge and purge. Automatic feedback messages were tailored to their self‐reported symptoms.ResultsFully 87% of participants adhered to self‐monitoring and reported good acceptability. The number of binge eating and purging episodes as well as symptoms of depression (BDI), eating disorder (EDI), and night eating (NES) decreased significantly from baseline to both post‐treatment and follow‐up.DiscussionGiven the frequent use of mobile phones and text‐messaging globally, this proof‐of‐principle study suggests their use may enhance self‐monitoring and treatment for BN leading to improved attendance, adherence, engagement in treatment, and remission from the disorder. © 2009 by Wiley Periodicals, Inc. Int J Eat Disord 2010; 43:513–519
A prospective study of cognitive tests to predict performance on a standardised road test in people with dementia
Authors: Lincoln Nadina B. , Taylor Jenny L. , Vella Kristina , Bouman Walter P. , Radford Kathryn A. 
Published: August 2009

AbstractObjectivePrevious work by Lincoln and colleagues produced a cognitive test battery for predicting safety to drive in people with dementia. The aim was to check the accuracy of this battery and assess whether it could be improved by shortening it, including additional cognitive tests, and a measure of previous driving.MethodsParticipants with dementia, who were driving, were recruited. They were assessed on cognitive tests including measures of concentration, executive function, visuospatial perception, verbal recognition memory, and speed of information processing. Patients were then assessed on the Nottingham Neurological Driving Assessment (NNDA) by an approved driving instructor (ADI), blind to cognitive test results.ResultsSeventy‐five patients were recruited and completed the cognitive tests. Of these, 65 were assessed on the road. These participants were aged 59–88 (mean = 75.2, SD = 6.8) and 49 were men. Time driving varied from 19 to 73 years (mean = 52.5, SD = 10.0). Thirteen participants were unsafe and 52 safe to drive. Using a cut‐off of > 0 to indicate safety to drive, the original predictive equations correctly classified 48 (76.2%) of 63 participants with complete data. Logistic regression including additional tests reduced misclassifications.ConclusionsA lower proportion of participants were found to be unsafe on the road than in previous studies. Nevertheless, the previously identified equation predicted safety to drive in most patients. Including additional tests reduced the misclassification rate but requires independent validation. We suggest that the cognitive test battery might be used in clinical practice to identify patients with dementia who would benefit from on‐road assessment. Copyright © 2009 John Wiley & Sons, Ltd.
Imaging of tumor vasculature using Twente photoacoustic systems
Authors: Jose Jithin , Manohar Srirang , Kolkman Roy G. M. , Steenbergen W. , van Leeuwen Ton G. 
Published: August 2009

AbstractPhotoacoustic imaging is a hybrid imaging modality based on the detection of acoustic waves generated by the absorption of short laser pulses in biological tissue. It combines the advantages of excellent contrast achieved in optical techniques with the high resolution of ultrasound imaging. In this article we present a review of the work done at the University of Twente to image tumor angiogenesis in vivo using this technique. We start with a description and the technical details of the different photoacoustic systems developed in our laboratory, with their validation on phantoms. We then discuss small‐animal studies with results of serial imaging of angiogenesis over a 10‐day period at the site of tumor induction in a rat. Further, we present clinical results using a photoacoustic mammoscope of breast cancer imaging based on angiogenesis‐driven optical absorption contrast. (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Tissue viability (TiVi) imaging: temporal effects of local occlusion studies in the volar forearm
Authors: McNamara Paul M. , O'Doherty Jim , O'Connell Marie‐Louise , Fitzgerald Barry W. , Anderson Chris D. , Nilsson Gert E. , Toll Rani , Leahy Martin J. 
Published: August 2009

AbstractTissue Viability (TiVi) imaging is a promising new technology for the assessment of microcirculation in the upper human dermis. Although the technique is easily implemented and develops large amounts of observational data, its role in the clinical workplace awaits the development of standardised protocols required for routine clinical practice. The present study investigates the use of TiVi technology in a human, in vivo, localized, skin blood flow occlusion protocol. In this feasibility study, the response of the cutaneous microcirculation after provocation on the volar surface of the forearm was evaluated using a high temporal‐low spatial resolution TiVi camera. 19 healthy subjects – 10 female and 9 male – were studied after a localized pressure was applied for 5 different time periods ranging from 5 to 25 seconds. Areas corresponding to 100 × 100 pixels (2.89 cm2) were monitored for 60 seconds prior to, during and after each occlusion period. Our results demonstrated the removal of blood from the local area and a hyperaemic response supporting the suitability of TiVi imaging for the generation of detailed provocation response data of relevance for the physiological function of the skin microcirculation in health and disease. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins
Authors: Kleino Iivari , Ortiz Rebekka M. , Yritys Miljamartta , Huovila Ari‐Pekka J. , Saksela Kalle 
Published: August 2009

AbstractA Disintegrin And Metalloprotease (ADAM15) is a member of the adamalysin protein family and has been associated with cancer, possibly via its role in ectodomain shedding of cadherins. Alternative mRNA splicing generates several ADAM15 isoforms containing different combinations of putative Src homology‐3 (SH3) domain binding sites in their cytosolic tails. Here we present a comprehensive characterization of SH3 binding potential of different ADAM15 isoforms. Alternative use of ADAM15 exons was found to profoundly influence selection of SH3‐containing cellular partner proteins, including the avid interactions with nephrocystin and sorting nexin‐33 (SNX33 a.k.a. SNX30). Specifically, strong co‐precipitation of nephrocystin from cell lysates was specific to ADAM15 isoforms i4, i5, and i6. These isoforms contain one or both of the two almost identical proline‐rich regions encoded by exons 20 and 21, wherein the residues RxLPxxP were found to be indispensable for nephrocystin SH3 binding. Similarly, robust cellular association with SNX33 was observed only for ADAM15 isoforms containing the most carboxyterminal proline cluster lacking in isoforms i1 and i3. Thus, alternative mRNA splicing provides a versatile mechanism for regulation of intracellular protein interactions and thereby likely the cellular functions of ADAM15, which could explain the association with cancer of some but not all ADAM15 isoforms. J. Cell. Biochem. 108: 877–885, 2009. © 2009 Wiley‐Liss, Inc.
Expression of caveolin‐1 in hepatic cells increases oxidized LDL uptake and preserves the expression of lipoprotein receptors
Authors: Truong To Quyen , Brodeur Mathieu R. , Falstrault Louise , Rhainds David , Brissette Louise 
Published: August 2009

AbstractOxidized LDL (OxLDL) that are positively associated with the risk of developing cardiovascular diseases are ligands of scavenger receptor‐class B type I (SR‐BI) and cluster of differentiation‐36 (CD36) which can be found in caveolae. The contribution of these receptors in human hepatic cell is however unknown. The HepG2 cell, a human hepatic parenchymal cell model, expresses these receptors and is characterized by a very low level of caveolin‐1. Our aim was to define the contribution of human CD36, SR‐BI, and caveolin‐1 in the metabolism of OxLDL in HepG2 cells and conversely the effects of OxLDL on the levels/localization of these receptors. By comparing mildly (M)‐ and heavily (H)‐OxLDL metabolism between control HepG2 cells and HepG2 cells overexpressing CD36, SR‐BI, or caveolin‐1, we found that (1) CD36 increases M‐ and H‐OxLDL‐protein uptake; (2) SR‐BI drives M‐OxLDL through a degradation pathway at the expense of the cholesterol ester (CE) selective uptake pathway; (3) caveolin‐1 increases M‐ and H‐OxLDL‐protein uptake and decreases CE selective uptake from M‐OxLDL. Also, incubation with M‐ or H‐OxLDL decreases the levels of SR‐BI and LDL‐receptor in control HepG2 cells which can be overcome by caveolin‐1 expression. In addition, OxLDL move CD36 from low to high buoyant density membrane fractions, as well as caveolin‐1 in cells overexpressing this protein. Thus, hepatic caveolin‐1 expression has significant effects on OxLDL metabolism and on lipoprotein receptor levels. J. Cell. Biochem. 108: 906–915, 2009. © 2009 Wiley‐Liss, Inc.
Efficient identification of tubby‐binding proteins by an improved system of T7 phage display
Authors: Caberoy Nora B. , Zhou Yixiong , Jiang Xiaoyu , Alvarado Gabriela , Li Wei 
Published: August 2009

AbstractMutation in the tubby gene causes adult‐onset obesity, progressive retinal, and cochlear degeneration with unknown mechanism. In contrast, mutations in tubby‐like protein 1 (Tulp1), whose C‐terminus is highly homologous to tubby, only lead to retinal degeneration. We speculate that their diverse N‐terminus may define their distinct disease profile. To elucidate the binding partners of tubby, we used tubby N‐terminus (tubby‐N) as bait to identify unknown binding proteins with open‐reading‐frame (ORF) phage display. T7 phage display was engineered with three improvements: high‐quality ORF phage display cDNA library, specific phage elution by protease cleavage, and dual phage display for sensitive high throughput screening. The new system is capable of identifying unknown bait‐binding proteins in as fast as ∼4–7 days. While phage display with conventional cDNA libraries identifies high percentage of out‐of‐frame unnatural short peptides, all 28 tubby‐N‐binding clones identified by ORF phage display were ORFs. They encode 16 proteins, including 8 nuclear proteins. Fourteen proteins were analyzed by yeast two‐hybrid assay and protein pull‐down assay with ten of them independently verified. Comparative binding analyses revealed several proteins binding to both tubby and Tulp1 as well as one tubby‐specific binding protein. These data suggest that tubby‐N is capable of interacting with multiple nuclear and cytoplasmic protein binding partners. These results demonstrated that the newly‐engineered ORF phage display is a powerful technology to identify unknown protein–protein interactions. Copyright © 2009 John Wiley & Sons, Ltd.
Cupric ion enhanced molecular imprinting of bovine serum albumin in hydrogel
Authors: Li Sheng‐Hua , Wang Jun , Zhao Mei‐Ping 
Published: August 2009

AbstractA novel molecularly imprinted hydrogel for bovine serum albumin (BSA) was prepared using cupric ion as the bridge between the template BSA and the functional monomer 4‐vinylpyridine. N‐Isopropylacrylamide (NIPA) was used as an assistant monomer to provide the stimuli‐responsibility of the polymer. The adsorption conditions of BSA on the BSA‐Cu(II)‐imprinted hydrogel were optimized considering the influences of pH, temperature, and salt concentration. The proteins bound on the imprinted hydrogel can be easily recovered under mild conditions by using 10 mmol/L ethylene diamine tetraacetic acid (EDTA) (pH 7.0) containing 150 mmol/L NaCl as the eluting solution. The imprinting effect and adsorption capacity of the polymer were found to be significantly improved compared to the hydrogel prepared in the absence of cupric ion. The results demonstrated the advantages of using a template‐metal ion‐monomer coordination system to strengthen the interaction between the protein and monomer. The effects of different metals ions including Zn(II), Ni(II), Co(II), Cd(II), and Al(III) on the recognition ability of the BSA‐Cu(II)‐imprinted hydrogel were also investigated. The polymer showed high selectivity toward both the template protein and the cupric ion.