bluuebunny/crossref_metadata_2025_split huggingface dataset:
End-of-Life as a New Beginning: Pre-demolition Audits, Digital Platforms and Skilled Labour as Enablers of Circular Economy
Authors: Pedroso Pedro Frazão , Silvestre José Dinis , Costa António Aguiar 
Published: May 2024

AbstractOne of the main issues with applying Circular Economy (CE) principles to the construction sector sits at the End-of-Life (EoL) of buildings. How to recover the materials and then how to reintroduce them into the economy are fundamental problems that lack immediate solutions. The status quo in the EoL of buildings has always been demolition followed by deposition at a landfill (linear economy), thus, to change this approach, there is the need to replace demolition with deconstruction. This causes new problems, as buildings vary greatly, there is a need for pre-demolition audits, that can report on the recoverable materials, potential generated waste and plan the deconstruction intervention. Here, new problems arise, such as the lack of methodologies to intervene or skilled labour that makes deconstruction possible. However, at that point, even when materials are recovered there is the problem of how to reintroduce those materials back into the market. Here, digital platforms can bridge that gap, making it possible for the recovered materials to be posted in a marketplace where the designers of new buildings (or building renovations) can access the circular materials available to introduce into their designs. Thus, this paper aims to present a possible solution to the problem of introducing CE into the built environment, proposing pre-demolition audits, digital platforms, and labour upskilling as enablers for a greener future.
The Sonic Imagery of the Covid-19 Pandemic
Authors: Varoutsos Georgios , D’Arcy John 
Published: May 2024

AbstractThe Covid-19 pandemic catalysed disruptions and disturbances in ways of living across the globe. Many of these changes in daily life were felt through stark changes to our soundscapes, particularly those in urban centres. Might we better understand the effects of the Covid-19 lockdowns through sonic analysis? This chapter explores how sound analysis methods, including concepts of the sound-motion object and sonic image, might aid in understanding the environmental soundscapes of the pandemic lockdowns. The discussion focuses on the Sounding Covid-19 project—an initiative involving a series of field recordings carried out during Covid-19 pandemic-related events in the urban environments of Belfast, Northern Ireland (2020–2022) and Montreal, Canada (2020–2021). The project presents the sound archive through various listening experiences, including soundscape compositions, sound mapping and narrative-based radiophonic work. We consider how the pandemic may have invited us to pause and reconsider how we document and archive the present to look back and better understand the future. Sound may be vital in understanding our environment and the socio-cultural shifts over time. This chapter argues that documenting, preserving, and analysing the soundscapes of the pandemic lockdowns may help us reflect on our shared histories in several ways.
Empirical Analysis of Gestural Sonic Objects Combining Qualitative and Quantitative Methods
Authors: Visi Federico , Schramm Rodrigo , Frödin Kerstin , Unander-Scharin Åsa , Östersjö Stefan 
Published: May 2024

AbstractIn this chapter, we describe a series of studies related to our research on using gestural sonic objects in music analysis. These include developing a method for annotating the qualities of gestural sonic objects on multimodal recordings; ranking which features in a multimodal dataset are good predictors of basic qualities of gestural sonic objects using the Random Forests algorithm; and a supervised learning method for automated spotting designed to assist human annotators. The subject of our analyses is a performance of Fragmente2, a choreomusical composition based on the Japanese composer Makoto Shinohara’s solo piece for tenor recorder Fragmente (1968). To obtain the dataset, we carried out a multimodal recording of a full performance of the piece and obtained synchronised audio, video, motion, and electromyogram (EMG) data describing the body movements of the performers. We then added annotations on gestural sonic objects through dedicated qualitative analysis sessions. The task of annotating gestural sonic objects on the recordings of this performance has led to a meticulous examination of related theoretical concepts to establish a method applicable beyond this case study. This process of gestural sonic object annotation—like other qualitative approaches involving manual labelling of data—has proven to be very time-consuming. This motivated the exploration of data-driven, automated approaches to assist expert annotators.
Embodied Sonic Design: Sound and the Sensory Apprehension of Movement
Authors: Crowe Gemma L. 
Published: May 2024

AbstractSound acts as an extension of the body, created by movement and received as vibration. I am focused on the removal of a visual representation of the body as a template; to instead facilitate an embodied experience. As an embodied practitioner, I create immersive sound and media installations derived from recordings of my own moving body. The movement of sound depicts the presence of a body in motion through sensory illusion. Through embodied sonic design, my sound recordings decontextualize, abstract, and reframe the auditory experience. I physically manipulate the recording of sound to perceptually rematerialize the moving physical form during playback with two techniques: sound shadows and embodied binaural spatialization. These techniques encourage the listener to perceive sound and space with the same awareness that situates their body, such as sensation and proprioception. The perceived physical interaction within the reception of this sound is akin to a kinesthetic projection and is an engagement in spatial thinking, activating mirror neurons and kinesthetic empathy. Creating awareness through physical attunement can regulate systems out of balance by offering the embodiment of alternative states: shifting how one thinks and feels in a particular setting. My research seeks to recognize the listener’s unique perspective through their individual body.
Digitale Kulturen der Lehre entwickeln
Authors: Mrohs Lorenz , Herrmann Dominik , Franz Julia , Lindner Konstantin , Staake Thorsten 
Published: May 2024

ZusammenfassungDer Beitrag führt vor dem Hintergrund der Theorie der Kultur der Digitalität (Felix Stalder) in den vorliegenden Sammelband ein und wendet diesen theoretischen Rahmen auf Hochschulen und die Entwicklung der Hochschullehre an. Es werden die zentralen Strukturbedingungen umrissen und davon ausgehend Erfordernisse für die Entwicklung einer Kultur der Digitalität an der Universität Bamberg skizziert, die im Rahmen des Projekts „Digitale Kulturen der Lehre entwickeln (DiKuLe)“ beforscht und entwickelt werden. Abschließend gibt der Beitrag einen Ausblick auf die Beiträge des Sammelbandes, die neue Konzepte, Gestaltungsmöglichkeiten und Evaluationsergebnisse digitaler Lehr-Lernarrangements vorstellen.
Storytelling bei der Vermittlung von Data Literacy in der Hochschullehre – ein Praxisbeispiel
Authors: Erhardt Yvonne , Gausling Pia , Böhm-Kasper Oliver 
Published: May 2024

ZusammenfassungIn diesem Beitrag wird der interaktive Online-Kurs Mit Emma durch den Datendschungel vorgestellt, welcher an der Fakultät für Erziehungswissenschaft der Universität Bielefeld im Rahmen der Förderlinie Curriculum 4.0.nrw entwickelt und erprobt wird. Ziel ist es, Data Literacy an Studierende der Erziehungswissenschaft und der Bildungswissenschaften zu vermitteln. Inhaltlich orientiert sich der Kurs an dem Datenlebenszyklus. Didaktisch liegt dem Kurs die Methode des Storytellings zugrunde.
Embedded Micro Degree an der RWU – Umsetzung eines MATLAB-Grundlagenkurses als Best-Practice-Beispiel
Authors: Frey Ilona , Kaufmann Saara 
Published: May 2024

ZusammenfassungMit dem Lehr-Lernformat Micro Degrees passt sich das Bildungssystem dem schnelllebigen, digitalen Wandel in der Gesellschaft und Arbeitswelt an. In diesem Beitrag wird der Aufbau eines Embedded Micro Degrees (MDs) anhand eines ersten Best-Practice-Beispiels zum Thema MATLAB-Grundlagen an der Hochschule Ravensburg-Weingarten (RWU) beschrieben. Besonders wird dabei auf die Umsetzung des MDs eingegangen und die dafür angewendeten Tools beschrieben. Eine wichtige Rolle spielen dabei Open Badges, die nach erfolgreichem Bestehen eines MDs vergeben werden.
Bedingungsfaktoren eines erfolgreichen Blended Learnings
Authors: Kastl Pia , Stöckl Andreas , Struck Olaf 
Published: May 2024

ZusammenfassungIm Zuge der Digitalisierung der Hochschullehre hat auch Blended Learning als Kombination aus Präsenz- und Onlinelehre zunehmende Verbreitung gefunden. Ziel des Beitrags ist es, die aktuellen Bedingungen der Anwendung zu analysieren und zu untersuchen, welche Faktoren für eine erfolgreiche Blended-Learning-Veranstaltung gegeben sein müssen. Hierfür wurden eine Fragebogenuntersuchung und qualitative Interviews mit Studierenden an zwei deutschen Universitäten durchgeführt. Die Ergebnisse zeigen, dass formale Faktoren wie Strukturierung und Unterstützung im Blended Learning bereits sehr gut gewährleistet werden. Verbesserungspotenziale bestehen in der Möglichkeit zur Kooperation der Studierenden untereinander. Aus Perspektive der Studierenden ist diese aktiv von den Dozierenden zu initiieren.
Aufgabenbearbeitungen von Schüler:innen multimedial erfassen
Authors: Kunz Saskia Jessica 
Published: May 2024

ZusammenfassungGrundschullehramtsstudierende der Martin-Luther-Universität Halle-Wittenberg erhalten im Rahmen eines wahlobligatorischen Lehr-Lernlabor-Seminars die Möglichkeit, theoriebasiert Lernaufgaben für den Rechtschreibunterricht zu entwickeln und diese mit Grundschüler:innen zu erproben. Um detaillierte Einblicke in die Bearbeitungs- und Kommunikationsprozesse der Schüler:innen zu erhalten, werden via Screencast (Bildschirmaufnahme) die Gespräche der Schüler:innen simultan mit ihren Bearbeitungen am Tablet-PC aufgezeichnet. Die Videovignetten dienen den Studierenden als Reflexionsgrundlage zur Identifikation von Problemstellen und Hürden in ihrer eigens entwickelten Aufgabe. Sie geben Anhaltspunkte zur gezielten Überarbeitung des Aufgabendesigns
Lehre qualitativer Forschungsmethoden im digitalen Raum und ihre didaktische Ausgestaltung
Authors: Epp André 
Published: May 2024

ZusammenfassungIn dem Beitrag werden zum einen Einblicke in eine mit dem didaktischen Konzept des flipped classrooms im digitalen Raum ausgebrachten Vorlesung zu qualitativen Forschungsmethoden gegeben. Es wird veranschaulicht, wie asynchrone und synchrone Phasen mit digitalen Elementen ausgestaltet und aufeinander bezogen werden. Zum anderen wird die Lehrveranstaltung empirisch in den Blick genommen und perspektiviert, wie Studierende mit den unterschiedlichen Elementen der im digitalen Raum ausgebrachten Vorlesung umgegangen sind und diese erfahren haben. Es wird aufgezeigt, dass Studierende zwischen Freiheiten, die mit dem didaktischen Konzept des flipped classrooms einhergehen, und dem Schaffen eigener Verbindlichkeiten changieren und die digitalen Elemente an ihren eigenen Lernbedarf ausrichten.
Die Corona-Pandemie: Zeitenwende oder nur ein kurzes Intermezzo in der Prüfungskultur?
Authors: Baume Matthias , Muris-Wendt Nina 
Published: May 2024

ZusammenfassungVor Beginn der Corona-Pandemie fanden an den meisten Universitäten und Hochschulen in Deutschland die Prüfungen fast ausschließlich analog und in Präsenz statt. Doch durch das Infektionsgeschehen mussten nahezu alle dieser Einrichtungen kurzfristig auf verschiedene Online-Prüfungsformate ausweichen. Da an der TU München im Rahmen eines Projekts zu diesem Zeitpunkt eine grundlegende Infrastruktur für automatisiert beaufsichtigte Prüfungen vorhanden war, wurde während der Corona-Semester eine große Anzahl von Prüfungen in diesem Format durchgeführt. Die Prüfungsevaluationen aus vier Semestern geben nun einen Einblick in die Veränderung der Wahrnehmung dieser Prüfungsform durch die Studierenden über die Zeit und tragen somit zur Beschreibung der aktuellen Prüfungskultur bei.
Rollenbeschreibungen von Hochschullehrenden im Kontext der Digitalisierung
Authors: Vogel Anne , Riedel Jana , Henschler Julia 
Published: May 2024

ZusammenfassungHochschullehrende sehen sich, auch infolge der durch die COVID-19-Pandemie forcierten Digitalisierung der Hochschullehre, mit neuen Aufgaben und veränderten Erwartungen konfrontiert. Der Beitrag untersucht im Rahmen eines Scholarship-of-Academic-Development-Ansatzes Veränderungen in der Wahrnehmung von Lehrrollen durch die digital gestützte Lehre. In diesem Zusammenhang setzt er sich eingehend mit den Aufgaben und Kompetenzen von Lehrenden, den an sie gestellten Erwartungen und Herausforderungen sowie der arbeitsteiligen Zusammenarbeit zwischen Lehrenden und anderen Hochschulmitarbeitenden auseinander. Die Erhebung fand im Rahmen einer Veranstaltung zur Rollenvielfalt in der digital gestützten Hochschullehre des Projekts „Digitalisierung der Hochschulbildung“ in Sachsen statt.
Innovativ sein: Verständnis von innovativer Lehre in der Lehrer:innenbildung und Implikationen für die Förderung innovativer Lehrkonzepte im Sinne einer modernen Hochschullehre
Authors: Kofahl Paula 
Published: May 2024

ZusammenfassungInnovationen in der Hochschullehre sichern deren Qualität und ermöglichen die Reaktion auf gesellschaftliche Entwicklungen. Angehende Lehrer:innen auf die Bedingungen der Digitalität vorzubereiten, bedingt die Weiterentwicklung von Lehrkonzepten in der Lehrer:innenbildung. Der Beitrag bietet Einblick in das Unterstützungsangebot „Vordenker:innen – Lehre neu gedacht“ an der MLU Halle-Wittenberg. Ziel des Programms ist es, Lehrende der Lehrer:innenbildung zum innovativen Handeln zu befähigen und Herausforderungen im Einsatz mit digitalen Medien zu bewältigen. In der Begleitforschung wurden das Verständnis zu innovativer Lehre sowie die Bedeutung struktureller und kultureller Bedingungen für innovative Lehrentwicklung aus Lehrendenperspektive ermittelt und Maßnahmen zur Förderung abgeleitet.
Building data for stacky covers
Authors: Ahlqvist Eric 
Published: May 2024

AbstractWe define stacky building data for stacky covers in the spirit of Pardini and give an equivalence of (2,1)-categories between the category of stacky covers and the category of stacky building data. We show that every stacky cover is a flat root stack in the sense of Olsson and Borne–Vistoli and give an intrinsic description of it as a root stack using stacky building data. When the base scheme S is defined over a field, we give a criterion for when a birational building datum comes from a tamely ramified cover for a finite abelian group scheme, generalizing a result of Biswas–Borne.
Mitigating the effect of source structure in geodetic VLBI by re-weighting observations using closure delays and baseline-to-jet orientation
Authors: Kareinen Niko , Zubko Nataliya , Savolainen Tuomas , Xu Ming Hui , Poutanen Markku 
Published: May 2024

AbstractAn ideal target for geodetic very long baseline interferometry (VLBI) is a strong and point-like radio source. In reality, most celestial sources used in geodetic VLBI have spatial structure. This is as a major source of error in VLBI Global Observing System (VGOS) and also affects legacy S/X observations. Source structure causes a systematic delay, which can affect the geodetic estimates if not modelled or otherwise accounted for. In this work, we aim to mitigate its impact by extending the stochastic model used in the least-squares fitting of the VLBI group delays. We have developed a weighting scheme to re-weight the observations by parameterizing the source structure component in terms of closure delays and jet orientation relative to the observing baseline. It was implemented in the Vienna VLBI Software. To assess the performance of the extended stochastic model, we analysed the CONT17 legacy sessions and generated suitable reference solutions for comparison. The effects of re-weighting were evaluated with respect to the session fit statistics, source-wise residuals, and geodetic parameters. We find that this relatively simple noise model consistently improves the session fit by about 5% with moderate variation from session to session. The geodetic estimates are not affected to a significant level by this new weighting method. Source-wise we see improved post-fit residuals for 63 out of a total of 91 sources observed.
Nicotine exacerbates liver damage in a mice model of Ehrlich ascites carcinoma through shifting SOD/NF-κB/caspase-3 pathways: ameliorating role of Chlorella vulgaris
Authors: Abu-Zeid Ehsan H. , El-Hady Eman W. , Ahmed Gehan A. , Abd-Elhakim Yasmina M. , Ibrahim Doaa , Abd-Allah Noura A. , Arisha Ahmed H. , Sobh Mohammed S. , Abo-Elmaaty Azza M. A. 
Published: May 2024

AbstractNicotine, a pervasive global environmental pollutant, is released throughout every phase of the tobacco’s life cycle. This study examined the probable ameliorative role of Chlorella vulgaris (ChV) extract against nicotine (NIC)-induced hepatic injury in Ehrlich ascites carcinoma (EAC) bearing female Swiss mice. Sixty female Swiss mice were assigned to four equal groups orally gavaged 2% saccharin 0.2 mL/mouse (control group), orally intubated 100 mg ChV /kg (ChV group), orally intubated 100 µg/mL NIC in 2% saccharin (NIC group), and orally intubated NIC + ChV as in group 3 and 2 (NIC+ChV group). The dosing was daily for 4 weeks. Mice from all experimental groups were then inoculated intraperitoneally with viable tumor cells 2.5 × 106 (0.2 mL/mouse) in the fourth week, and the treatments were extended for another 2 weeks. The results have shown that NIC exposure significantly altered the serum levels of liver function indices, lipid profile, LDH, and ALP in the NIC-exposed group. NIC administration significantly increased hepatic inflammation, lipid peroxidation, and DNA damage-related biomarkers but reduced antioxidant enzyme activities. NIC exposure downregulated SOD1, SOD2, CAT, GPX1, and GPX2 but upregulated NF-κB hepatic gene expression. Notably, the presence of the EAC cells outside the liver was common in all mice groups. Liver tissue of the NIC-exposed group showed multifocal expansion of hepatic sinusoids by neoplastic cells. However, with no evidence of considerable infiltration of EAC cells inside the sinusoids or in periportal areas in the NIC + ChV groups. NIC significantly altered caspase-3, Bax, and BcL2 hepatic immune expression. Interestingly, ChV administration significantly mitigates NIC-induced alterations in hepatic function indices, lipid profile, and the mRNA expression of antioxidant and NF-κB genes and regulates the caspase-3, Bax, and BcL2 immunostaining. Finally, the in vivo protective outcomes of ChV against NIC-induced hepatic injury combined with EAC in female Swiss mice could suggest their helpful role for cancer patients who are directly or indirectly exposed to NIC daily.
Imaging CAR-NK cells targeted to HER2 ovarian cancer with human sodium-iodide symporter-based positron emission tomography
Authors: Shalaby Nourhan , Xia Ying , Kelly John J , Sanchez-Pupo Rafael , Martinez Francisco , Fox Matthew S , Thiessen Jonathan D , Hicks Justin W , Scholl Timothy J , Ronald John A. 
Published: May 2024

AbstractChimeric antigen receptor (CAR) cell therapies utilize CARs to redirect immune cells towards cancer cells expressing specific antigens like human epidermal growth factor receptor 2 (HER2). Despite their potential, CAR T cell therapies exhibit variable response rates and adverse effects in some patients. Non-invasive molecular imaging can aid in predicting patient outcomes by tracking infused cells post-administration. CAR-T cells are typically autologous, increasing manufacturing complexity and costs. An alternative approach involves developing CAR natural killer (CAR-NK) cells as an off-the-shelf allogeneic product. In this study, we engineered HER2-targeted CAR-NK cells co-expressing the positron emission tomography (PET) reporter gene human sodium-iodide symporter (NIS) and assessed their therapeutic efficacy and PET imaging capability in a HER2 ovarian cancer mouse model.NK-92 cells were genetically modified to express a HER2-targeted CAR, the bioluminescence imaging reporter Antares, and NIS. HER2-expressing ovarian cancer cells were engineered to express the bioluminescence reporter Firefly luciferase (Fluc). Co-culture experiments demonstrated significantly enhanced cytotoxicity of CAR-NK cells compared to naive NK cells. In vivo studies involving mice with Fluc-expressing tumors revealed that those treated with CAR-NK cells exhibited reduced tumor burden and prolonged survival compared to controls. Longitudinal bioluminescence imaging demonstrated stable signals from CAR-NK cells over time. PET imaging using the NIS-targeted tracer 18F-tetrafluoroborate ([18F]TFB) showed significantly higher PET signals in mice treated with NIS-expressing CAR-NK cells.Overall, our study showcases the therapeutic potential of HER2-targeted CAR-NK cells in an aggressive ovarian cancer model and underscores the feasibility of using human-derived PET reporter gene imaging to monitor these cells non-invasively in patients.
Ultra-low-dose vs. standard-of-care-dose CT of the chest in patients with post-COVID-19 conditions—a prospective intra-patient multi-reader study
Authors: Wassipaul Christian , Kifjak Daria , Milos Ruxandra-Iulia , Prayer Florian , Roehrich Sebastian , Winter Melanie , Beer Lucian , Watzenboeck Martin L. , Pochepnia Svitlana , Weber Michael , Tamandl Dietmar , Homolka Peter , Birkfellner Wolfgang , Ringl Helmut , Prosch Helmut , Heidinger Benedikt H. 
Published: May 2024

Abstract
Objectives
To conduct an intrapatient comparison of ultra-low-dose computed tomography (ULDCT) and standard-of-care-dose CT (SDCT) of the chest in terms of the diagnostic accuracy of ULDCT and intrareader agreement in patients with post-COVID conditions.

Methods
We prospectively included 153 consecutive patients with post-COVID-19 conditions. All participants received an SDCT and an additional ULDCT scan of the chest. SDCTs were performed with standard imaging parameters and ULDCTs at a fixed tube voltage of 100 kVp (with tin filtration), 50 ref. mAs (dose modulation active), and iterative reconstruction algorithm level 5 of 5. All CT scans were separately evaluated by four radiologists for the presence of lung changes and their consistency with post-COVID lung abnormalities. Radiation dose parameters and the sensitivity, specificity, and accuracy of ULDCT were calculated.

Results
Of the 153 included patients (mean age 47.4 ± 15.3 years; 48.4% women), 45 (29.4%) showed post-COVID lung abnormalities. In those 45 patients, the most frequently detected CT patterns were ground-glass opacities (100.0%), reticulations (43.5%), and parenchymal bands (37.0%). The accuracy, sensitivity, and specificity of ULDCT compared to SDCT for the detection of post-COVID lung abnormalities were 92.6, 87.2, and 94.9%, respectively. The median total dose length product (DLP) of ULDCTs was less than one-tenth of the radiation dose of our SDCTs (12.6 mGy*cm [9.9; 15.5] vs. 132.1 mGy*cm [103.9; 160.2]; p < 0.001).

Conclusion
ULDCT of the chest offers high accuracy in the detection of post-COVID lung abnormalities compared to an SDCT scan at less than one-tenth the radiation dose, corresponding to only twice the dose of a standard chest radiograph in two views.

Clinical relevance statement
Ultra-low-dose CT of the chest may provide a favorable, radiation-saving alternative to standard-dose CT in the long-term follow-up of the large patient cohort of post-COVID-19 patients.