bluuebunny/crossref_metadata_2025_split huggingface dataset:
Equal‐length coupled‐serial‐shunted lines band‐pass filters with suppression of the second harmonic
Authors: Tsai Lin‐Chuan , Fang Han‐Sheng 
Published: June 2011

AbstractIn this letter, a new configuration consisting of parallel coupled lines and nonuniform transmission lines is used to study band‐pass filters. Using a combination of the wavy‐edge coupled‐lines and ring resonators of the harmonic pass‐band of the parallel‐coupled line filter is rejected more effectively. A synthesis method is presented for Chebyshev Type II band‐pass filters in the microwave frequency range. To validate the proposed methodology, measured, and simulation, Chebyshev Type II band‐pass filters were implemented to validate this new configuration correct by measuring. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26218
Optical leaky integrator with inverted and noninverted accumulation
Authors: Costanzo‐Caso Pablo A. , Siahmakoun Azad , Granieri Sergio 
Published: June 2011

AbstractThis paper describes a novel optical leaky integrator for an all‐optical Σ−Δ modulator. The device is designed and built in a non‐interferometric structure, which consists of a nonlinear fiber loop and a wavelength converter. The system is characterized for square input signals in MHz range. The integration time‐constant of the integrator can be easily adjusted over the full interval of the input period by modifying the semiconductor optical amplifier driving current. Experimental results are in excellent agreement with numerical simulations and are used to obtain Σ−Δ modulator design parameters. The operating frequency can be increased without difficulty up to GHz range simply by reducing the loop length. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26222
An XFEM method for modeling geometrically elaborate crack propagation in brittle materials
Authors: Richardson Casey L. , Hegemann Jan , Sifakis Eftychios , Hellrung Jeffrey , Teran Joseph M. 
Published: June 2011

AbstractWe present a method for simulating quasistatic crack propagation in 2‐D which combines the extended finite element method (XFEM) with a general algorithm for cutting triangulated domains, and introduce a simple yet general and flexible quadrature rule based on the same geometric algorithm. The combination of these methods gives several advantages. First, the cutting algorithm provides a flexible and systematic way of determining material connectivity, which is required by the XFEM enrichment functions. Also, our integration scheme is straightforward to implement and accurate, without requiring a triangulation that incorporates the new crack edges or the addition of new degrees of freedom to the system. The use of this cutting algorithm and integration rule allows for geometrically complicated domains and complex crack patterns. Copyright © 2011 John Wiley & Sons, Ltd.
Computational homogenization of coupled consolidation problems in micro‐heterogeneous porous media
Authors: Su Fang , Larsson Fredrik , Runesson Kenneth 
Published: June 2011

AbstractComputational homogenization is exploited for the analysis of transient hydro‐mechanically coupled problems subjected to quasistatic loading (consolidation) in micro‐heterogeneous porous solids. The classical approach of first‐order homogenization is adopted in the spatial domain on representative volume elements (RVE), which are introduced in quadrature points in standard fashion. Along with the classical averages, a higher order conservation quantity is obtained. An iterative FE 2‐algorithm is devised for the case of nonlinear permeability and storage coefficients, and it is applied to pore pressure changes in asphalt‐concrete (particle composite). Various parametric studies are carried out, in particular with respect to the influence of the characteristics (size, particle arrangement) of the RVE's. Copyright © 2011 John Wiley & Sons, Ltd.
Soluble interleukin‐2 receptor α activation in a Children's Oncology Group randomized trial of interleukin‐2 Therapy for Pediatric Acute Myeloid Leukemia
Authors: Lange Beverly J. , Yang Richard K. , Gan Jacek , Hank Jaquelyn A. , Sievers Eric L. , Alonzo Todd A. , Gerbing Robert B. , Sondel Paul M. 
Published: June 2011

AbstractPurposeTo assess associations of soluble IL‐2 receptor alpha (sIL‐2rα) concentration with outcomes in pediatric acute myeloid leukemia (AML) in a phase 3 trial of IL‐2 therapy.ProceduresWe randomized 289 children with AML in first remission after intensive chemotherapy to receive IL‐2 infused on days 0–3 and 8–17 (IL‐2 group) or no further therapy (AML control group). We measured sequential serum sIL‐2rα concentrations in both groups before, during and after therapy in both groups and in reference controls without AML.ResultsBefore treatment, mean sIL‐2rα concentrations were similar in the IL‐2 group and AML controls, but significantly higher than in reference controls. Both AML groups experienced reduction in sIL‐2rα concentration after chemotherapy. Thereafter in the IL‐2 group, mean sIL‐2rα concentration increased from 2,669 pg/ml before IL‐2 to 15,534 pg/ml on day 4 (P < 0.001) and 10,585 pg/ml on day 18 (P < 0.001). In the control group sIL‐2rα concentration did not change after 28 days of follow‐up. Five‐year disease‐free survival (DFS) was 51% in the IL‐2 group and 58% in the controls (P = 0.489) and overall survival was 70% and 73%, respectively (P = 0.727).ConclusionSIL‐2rα concentration was elevated in AML at diagnosis and tended to normalize after chemotherapy. IL‐2 infusion significantly increased sIL‐2rα concentration, but did not improve DFS or survival in pediatric AML. Furthermore, sIL‐2rα concentration was not predictive of outcome before, during or after treatment for AML. Pediatr Blood Cancer 2011; 57: 398–405. © 2011 Wiley‐Liss, Inc.
Reduced‐intensity allogeneic stem cell transplantation for children with neuroblastoma who failed tandem autologous stem cell transplantation
Authors: Sung Ki Woong , Park Jun Eun , Chueh Hee Won , Lee Soo Hyun , Yoo Keon Hee , Koo Hong Hoe , Kim Ju Youn , Cho Eun Joo 
Published: June 2011

AbstractBackgroundTo date, no effective curative option is available for children with neuroblastoma (NB) who failed tandem high‐dose chemotherapy and autologous stem cell transplantation (HDCT/autoSCT). The present study evaluated the feasibility and efficacy of reduced‐intensity allogeneic stem cell transplantation (RI alloSCT) in six children with NB who failed tandem HDCT/autoSCT.ProcedureA cyclophosphamide/fludarabine regimen was used as a conditioning for HLA‐matched SCT, and ATG was added for haploidentical SCT. Peripheral blood stem cells from four HLA‐matched donors and two haploidentical donors were transplanted. Immune suppression was rapidly tapered if graft‐versus‐host disease (GVHD) was absent.ResultsRegimen‐related short‐term toxicity was manageable, and complete donor chimerism was achieved in the early period after transplant. Grade I/II acute GVHD developed or was induced in all patients. Tumor response, attributed to a graft‐versus‐tumor (GVT) effect, was observed in two of six patients after induction of acute GVHD. The other four patients with significant tumor burden prior to transplant had tumor progression despite presence of GVHD. However, it was difficult to effectively reduce the tumor burden prior to transplant through the use of conventional treatment modalities.ConclusionAlthough regimen‐related short‐term toxicity was manageable in intensively pretreated patients with NB, GVT effect was not sufficiently strong to control tumor progression in patients who had a significant tumor burden at transplant. Therefore, new treatment modalities to effectively reduce tumor burden prior to transplant in concert with post‐transplant adjuvant treatment to enhance the GVT effect are needed to improve the outcome after RI alloSCT. Pediatr Blood Cancer 2011; 57: 660–665. © 2011 Wiley‐Liss, Inc.
Successful pulmonary artery embolectomy in a patient with a saddle Wilms tumor embolus
Authors: Cooper Lindsey , Moore Colin , Branchford Brian , Greffe Brian , Capocelli Kelley , Kuder Austine , Mehta Inder , Mourani Peter M 
Published: June 2011

AbstractDenys–Drash syndrome is a genetic disorder characterized by ambiguous genitalia, cryptorchidism, nephrotic syndrome, and a high predilection for Wilms tumor with intravascular invasion. We report a 5‐year‐old male with Denys–Drash syndrome who rapidly developed Wilms tumor with vascular invasion, subsequent saddle tumor embolus, and required emergent embolectomy. This case illustrates the rapid emergence of Wilms tumor in a patient with Denys–Drash syndrome and the importance of considering embolectomy over thrombolytic therapy for PE in this population, given a high likelihood of tumor embolus. Pediatr Blood Cancer 2012; 58: 806–809. © 2011 Wiley Periodicals, Inc.
Constitutional tandem duplication of 9q34 that truncates EHMT1 in a child with ganglioglioma
Authors: Cheung Hannah C. , Yatsenko Svetlana A. , Kadapakkam Meena , Legay Hélène , Su Jack , Lupski James R. , Plon Sharon E. 
Published: June 2011

AbstractPoint mutations of EHMT1 or deletions and duplications of chromosome 9q34.3 are found in patients with variable neurologic and developmental disorders. Here, we present a child with congenital cataract, developmental and speech delay who developed a metastatic ganglioglioma with progression to anaplastic astrocytoma. Molecular analysis identified a novel constitutional tandem duplication in 9q34.3 with breakpoints in intron 1 of TRAF2 and intron 16 of EHMT1 generating a fusion transcript predicted to encode a truncated form of EHMT1. The ganglioglioma showed complex chromosomal aberrations with further duplication of the dup9q34. Thus, this unique tandem 9q34.3 duplication may impact brain tumor formation. Pediatr Blood Cancer 2012; 58: 801–805. © 2011 Wiley Periodicals, Inc.
Current methodologies for proteomics of bacterial surface‐exposed and cell envelope proteins
Authors: Solis Nestor , Cordwell Stuart J. 
Published: June 2011

AbstractThe study of surface‐exposed proteins has received increasing attention following the advent of genomic sequencing, which in turn has enabled predictive tools and facilitated the technologies for their analysis by proteomics. The exterior topology of a bacterial pathogen is the interface between the cell and environment and thus is the initial mediator for infection, providing an important reservoir for components that may be used for novel vaccine development as well as the characterization of new drug targets. The study of such biological molecules has however, been under‐represented in proteomics studies due to the difficulty involved in their analysis. Cell‐envelope proteins in bacteria are typically difficult to characterize due to their low abundance, poor solubility, and the problematic isolation of pure surface fractions with only minimal contamination. Here, we describe different cell envelope preparations for proteomic characterization, focused principally on gel‐free technologies. Fractionation techniques popularly used in proteomics are also explained with emphasis on surface and membrane‐derived proteins/peptides. Conditional confirmation of localization is also explored with emphasis on different prediction algorithms as well as on analyses of surface peptide fractions by the use of different search programs and their implications for the unambiguous identification of surface‐exposed and membrane‐embedded proteins. Finally, different quantification techniques are discussed that are important for the validation of identifications and for highlighting novel proteins that may warrant further study by independent techniques.
Managing challenging behaviour in older adults with dementia
Authors: Krishnamoorthy Ashok , Anderson Dave 
Published: June 2011

AbstractChallenging behaviour is a very common problem in older people with dementia. It can increase caregiver stress, reduce quality of life and increase the risk of institutionalisation and admission to hospital. Here, Dr Krishnamoorthy and Dr Anderson discuss the aetiology and treatment of challenging behaviour, emphasising that understanding the reasons behind the behaviour is the key to effective management. Copyright © 2011 Wiley Interface Ltd
Concordance between tuberculin skin test and interferon‐γ assay and interferon‐γ response to mitogen in pediatric tuberculosis contacts
Authors: Thomas B. , Pugalenthi A. , Patel H. , Woltmann G. , Bankart J. , Hoskyns W. 
Published: June 2011

AbstractThere is paucity of data on the usefulness of Interferon (IFN)‐γ release assays in the diagnosis of latent tuberculosis infection (LTBI) in children. The aim of this study was to evaluate the concordance between tuberculin skin test (TST) and QuantiFERON®‐TB Gold in‐tube (QFT‐GIT) test, when used in contact screening to diagnose LTBI in asymptomatic children. We also aimed to determine if there is any correlation between age and the IFN‐γ response to the mitogen. Children assessed at Leicester Royal Infirmary and Glenfield hospital (Leicester, United Kingdom) as part of tuberculosis contact screening were studied. Two hundred and eighty three children (mean [SD] age 5.3 [4.1] years, 148 males) underwent clinical examination, chest radiograph, TST, and QFT‐GIT test. In this group, there was good agreement (κ = 0.70 [95%CI = 0.57–0.83], P < 0.0001) between TST and QFT‐GIT. Of the 18 children in this group with an indeterminate QFT‐GIT test result, all except one were <5‐years‐old. To study the correlation between age and the IFN‐γ response to the mitogen, results of 282 children who had QFT‐GIT test as part of tuberculosis contact screening during the study period were analyzed. A significant correlation was observed between age and the IFN‐γ response to the mitogen (r = 0.47, P < 0.001). Whilst our study re‐emphasizes the good overall concordance between TST and QFT‐GIT, the high rate of indeterminate results and the low IFN‐γ response to the mitogen seen in young children raise some concerns about the performance of IGRAs in this group. Pediatr Pulmonol. 2011; 46: 1225–1232. © 2011 Wiley Periodicals, Inc.
Improved signal processing and normalization for biomarker protein detection in broad‐mass‐range TOF mass spectra from clinical samples
Authors: Tracy Maureen B. , Cooke William E. , Gatlin Christine L. , Cazares Lisa H. , Weaver Dennis M. , Semmes O. John , Tracy Eugene R. , Manos Dennis M. , Malyarenko Dariya I. 
Published: June 2011

AbstractPurpose: To demonstrate robust detection of biomarkers in broad‐mass‐range TOF‐MS data.Experimental Design: Spectra were obtained for two serum protein profiling studies: (i) 2–200 kDa for 132 patients, 67 healthy and 65 diagnosed as having adult T‐cell leukemia and (ii) 2–100 kDa for 140 patients, 70 pairs, each with matched prostate‐specific antigen (PSA) levels and biopsy‐confirmed diagnoses of one benign and one prostate cancer. Signal processing was performed on raw spectra and peak data were normalized using four methods. Feature selection was performed using Bayesian Network Analysis and a classifier was tested on withheld data. Identification of candidate biomarkers was pursued.Results: Integrated peak intensities were resolved over full spectra. Normalization using local noise values was superior to global methods in reducing peak correlations, reducing replicate variability and improving feature selection stability. For the leukemia data set, potential disease biomarkers were detected and were found to be predictive for withheld data. Preliminary assignments of protein IDs were consistent with published results and LC‐MS/MS identification. No prostate‐specific‐antigen‐independent biomarkers were detected in the prostate cancer data set.Conclusions and clinical relevance: Signal processing, local signal‐to‐noise (SNR) normalization and Bayesian Network Analysis feature selection facilitate robust detection and identification of biomarker proteins in broad‐mass‐range clinical TOF‐MS data.
Aberrant expression of katanin p60 in prostate cancer bone metastasis
Authors: Ye Xiangcang , Lee Yu‐Chen , Choueiri Michel , Chu Khoi , Huang Chih‐Fen , Tsai Wen‐Wei , Kobayashi Ryuji , Logothetis Christopher J. , Yu‐Lee Li‐Yuan , Lin Sue‐Hwa 
Published: June 2011

AbstractBACKGROUNDKatanin p60 is a microtubule‐severing protein and is involved in microtubule cytoskeleton organization in both mitotic and non‐mitotic processes. Its role in cancer metastasis is unknown.METHODSDifferential protein profiles of bone marrow aspirates were analyzed by chromatography, electrophoresis, and mass spectrometry. Expression of katanin p60 in primary and metastatic prostate cancer was examined by immunohistochemistry. Cellular function of katanin p60 was further examined in prostate cell lines.RESULTSIn a proteomic profiling of bone marrow aspirates from men with prostate cancer, we found that katanin p60 was one of the proteins differentially expressed in bone metastasis samples. Immunohistochemical staining showed that katanin p60 was expressed in the basal cells in normal human prostate glands. In prostatic adenocarcinomas, in which the basal cells were absent, katanin p60 was expressed in the prostate cancer cells. In the specimens from bone metastasis, katanin p60 was detectable in the metastatic cancer cells. Strikingly, some of the metastatic cancer cells also co‐expressed basal cell biomarkers including the tumor suppressor p53‐homologous protein p63 and the high molecular weight cytokeratins, suggesting that the metastatic prostate cancer cells may have a basal cell‐like phenotype. Moreover, overexpression of katanin p60 inhibited prostate cancer cell proliferation but enhanced cell migration activity.CONCLUSIONSKatanin p60 was aberrantly expressed during prostate cancer progression. Its expression in the metastatic cells in bone was associated with the re‐emergence of a basal cell‐like phenotype. The elevated katanin p60 expression may contribute to cancer cell metastasis via a stimulatory effect on cell motility. Prostate 72:291–300, 2012. © 2011 Wiley Periodicals, Inc.
Surface‐based protein binding pocket similarity
Authors: Spitzer Russell , Cleves Ann E. , Jain Ajay N. 
Published: June 2011

AbstractProtein similarity comparisons may be made on a local or global basis and may consider sequence information or differing levels of structural information. We present a local three‐dimensional method that compares protein binding site surfaces in full atomic detail. The approach is based on the morphological similarity method which has been widely applied for global comparison of small molecules. We apply the method to all‐by‐all comparisons two sets of human protein kinases, a very diverse set of ATP‐bound proteins from multiple species, and three heterogeneous benchmark protein binding site data sets. Cases of disagreement between sequence‐based similarity and binding site similarity yield informative examples. Where sequence similarity is very low, high pocket similarity can reliably identify important binding motifs. Where sequence similarity is very high, significant differences in pocket similarity are related to ligand binding specificity and similarity. Local protein binding pocket similarity provides qualitatively complementary information to other approaches, and it can yield quantitative information in support of functional annotation. Proteins 2011; © 2011 Wiley‐Liss, Inc.
Field leaching of pesticides at five test sites in Hawaii: modeling flow and transport
Authors: Dusek Jaromir , Dohnal Michal , Vogel Tomas , Ray Chittaranjan 
Published: June 2011

AbstractBACKGROUND: Physically based tier‐II models may serve as possible alternatives to expensive field and laboratory leaching experiments required for pesticide approval and registration. The objective of this study was to predict pesticide fate and transport at five different sites in Hawaii using data from an earlier field leaching experiment and a one‐dimensional tier‐II model. As the predicted concentration profiles of pesticides did not provide close agreement with data, inverse modeling was used to obtain adequate reactive transport parameters. The estimated transport parameters of pesticides were also utilized in a tier‐I model, which is currently used by the state authorities to evaluate the relative leaching potential.RESULTS: Water flow in soil profiles was simulated by the tier‐II model with acceptable accuracy at all experimental sites. The observed concentration profiles and center of mass depths predicted by the tier‐II simulations based on optimized transport parameters provided better agreements than did the non‐optimized parameters. With optimized parameters, the tier‐I model also delivered results consistent with observed pesticide center of mass depths.CONCLUSION: Tier‐II numerical modeling helped to identify relevant transport processes in field leaching of pesticides. The process‐based modeling of water flow and pesticide transport, coupled with the inverse procedure, can contribute significantly to the evaluation of chemical leaching in Hawaii soils. Copyright © 2011 Society of Chemical Industry
Nucleation and transformation of circular magnetic‐domain structure in amorphous microwires
Authors: Chizhik Alexander , Zhukov Arcady , Gonzalez Julian , Blanco Juan Mari 
Published: June 2011

AbstractWe report investigations on surface magnetic‐domain structure in amorphous glass‐covered microwires using polar and longitudinal Kerr microscopy. For the first time the main stages of the surface magnetization reversal has been discovered: domain‐wall motion related to the formation of stable circular monodomain and the following multiplication of the number of domains that finishes in the formation of the reversed circularly magnetized state.
Domain structure, magnetic properties, and giant magnetoimpedance of FeNi/Ti‐based multilayers
Authors: Fernández E. , García‐Arribas A. , Barandiarán J. M. , Svalov A. V. , Kurlyandskaya G. V. 
Published: June 2011

AbstractMagnetic multilayers consisting of magnetic FeNi and non‐magnetic Ti layers were prepared by rf‐sputtering. Magnetic measurements and magnetic domain structure observations were used for characterization of the samples. The magnetoimpedance performance of FeNi/Ti‐based multilayers is evaluated in terms of the magnitude of the effect and its sensitivity with respect to applied magnetic field. The results show that the trilayer with Ti layer of 6 nm (sample A), deposited to avoid the possibility of appearance of a trascritical state, performs better than the sample with a 10 nm Ti layer (sample B). The best results are obtained with [FeNi/Ti]5/FeNi multilayered structure (sample C) reaching a value of about 60% of variation of the impedance at 180 MHz and a sensitivity of about 22%/Oe at 180 MHz.
Physical properties of CaCu3Ti4O12 obtained from different EDTA‐gel derived powders
Authors: Amaral Filipe , Valente Manuel , Costa Luís Cadillon 
Published: June 2011

AbstractWe report the synthesis and characterization of CaCu3Ti4O12 (CCTO) powders prepared by two different wet‐chemical methods: ethylenediaminetetraacetic acid‐gel method (EDTA) and modified Pechini (MP) process. In both cases, almost single‐phase CCTO fine powders were obtained from the calcination of the gel precursors at lower temperatures and shorter times than those reported for the conventional solid‐state reaction process. The structure of the calcinated powders and sintered pellets were characterized by X‐ray diffraction and scanning electron microscopy. Impedance spectroscopy measurements were performed on the sintered pellets obtained from the different powders, in the frequency range from 40 Hz to 110 MHz, at room temperature. The results are discussed and compared. High frequency relaxation data was fitted with Cole–Cole model and the calculated relaxation parameters were correlated with morphological and structural properties.