bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beating Bipolar: exploratory trial of a novel internet‐based psychoeducational treatment for bipolar disorder
Authors: Smith Daniel J , Griffiths Emily , Poole Ria , di Florio Arianna , Barnes Emma , Kelly Mark J , Craddock Nick , Hood Kerenza , Simpson Sharon 
Published: October 2011

Smith DJ, Griffiths E, Poole R, di Florio A, Barnes E, Kelly MJ, Craddock N, Hood K, Simpson S. Beating Bipolar: exploratory trial of a novel internet‐based psychoeducational treatment for bipolar disorder. Bipolar Disord 2011: 13: 571–577. © 2011 The Authors. Journal compilation © 2011 John Wiley & Sons A/S.Objectives:  Psychoeducational approaches are promising interventions for the long‐term management of bipolar disorder. In consultation with professionals, patients, and their families we have developed a novel web‐based psychoeducational intervention for bipolar disorder called Beating Bipolar. We undertook a preliminary exploratory randomized trial to examine efficacy, feasibility and acceptability.Methods:  This was an exploratory randomized controlled trial of Beating Bipolar (current controlled trials registration number: ISRCTN81375447). The control arm was treatment‐as‐usual and the a priori primary outcome measure was quality of life [measured by the brief World Health Organization Quality of Life (WHOQOL–BREF) scale]. Secondary outcomes included psychosocial functioning, insight, depressive and manic symptoms and relapse, and use of healthcare resources. Fifty participants were randomized to either the Beating Bipolar intervention plus treatment‐as‐usual or just treatment‐as‐usual. The intervention was delivered over a four‐month period and outcomes were assessed six months later.Results:  There was no significant difference between the intervention and control groups on the primary outcome measure (total WHOQOL–BREF score) but there was a modest improvement within the psychological subsection of the WHOQOL–BREF for the intervention group relative to the control group. There were no significant differences between the groups on any of the secondary outcome measures.Conclusions:  Beating Bipolar is potentially a safe and engaging intervention which can be delivered remotely to large numbers of patients with bipolar disorder at relatively low cost. It may have a modest effect on psychological quality of life. Further work is required to establish the impact of this intervention on insight, knowledge, treatment adherence, self‐efficacy and self‐management skills.
Evaluating the efficacy of neem (Azadirachta indica A. Juss) seed oil treatment for Bambusa vulgaris Schrad. against Pycnoporus sanguineus (L. ex Fr.) Murr. using static bending strength properties
Authors: Erakhrumen A. A. 
Published: October 2011

SummaryIn this study, split‐bamboo (Bambusa vulgaris Schrad. ex J.C. Wendl.) were converted to specimens for static bending strength tests (SBST) in conformity with modified ASTM D‐143–94 and treated by soaking two sets differently in mechanically extracted neem (Azadirachta indica A. Juss) seed oil at an ambient room temperature of 25 ± 2°C for 24 h (A) and 60°C for 4 h (B) with samples not treated with the oil as control. The oil‐treated (soaked and heat treated) and those that were not oil‐treated (control samples) were all inoculated with cultured Pycnoporus sanguineus (L. ex Fr.) Murr., incubated for 12 weeks and then subjected to SBST. Results obtained showed that Modulus of Rupture was lower for control (7941 ± 46 N cm−2) but higher for A (8954 ± 55 N cm−2) and B (8129 ± 70 N cm−2). Modulus of Elasticity was also lower for control (677 116 ± 3070 N cm−2) and higher for A (725 016 ± 3468 N cm−2) and B (724 391 ± 3204 N cm−2). Energy at maximum load, load at yield and extension at yield also followed similar trend. Data obtained were statistically analysed using basic descriptive tools and anova, while Fishers’ least significant difference was applied as a follow‐up test to compare means (p < 0.05).
Methyl eugenol and pre‐release diet improve mating performance of young Bactrocera dorsalis and Bactrocera correcta males
Authors: Orankanok W. , Chinvinijkul S. , Sawatwangkhoung A. , Pinkaew S. , Orankanok S. 
Published: October 2011

AbstractThe objective of this extensive series of experiments, involving more than 2800 field cage tests with potted mango trees, was to assess pre‐release supplements to enhance the mating success of sterile male Bactrocera dorsalis and Bactrocera correcta. We examined the effects of different pre‐release diets and methyl eugenol (ME), both independently and in combination. Tests were carried out more than 15 and 18 days for B. dorsalis and B. correcta, respectively, each day increasing the age of sterile flies. To evaluate the effect of different pre‐release diets on males, no‐choice mating tests were conducted with sterile males of increasing age and mature sterile females. Sterile males fed up to 2 days of age on sugar–yeast hydrolysate combinations achieved significantly more matings than males fed only water in B. dorsalis and more matings than males fed only sugar, only yeast hydrolysate or only water in B. correcta. To examine the effect of ME on mating performance, 2‐, 3‐, 4‐ or 5‐day‐old sterile males were given or not given access to ME for 1 h, followed by the sugar–protein diet until the day of the mating test. Mating performance tests were carried out with ME‐exposed and non‐exposed sterile males competing with mature wild males for wild females. Results showed a significant mating advantage of ME‐exposed over non‐exposed sterile males, although at younger ages they were still less competitive than wild males. The interaction of sugar–yeast hydrolysate diet and ME as pre‐release treatments for 2‐ and 3‐day‐old sterile males was assessed in terms of male sexual competitiveness. Overall, the combination showed an additive effect on increased mating success in B. dorsalis sterile males when competing a wild males for wild females, while in B. correcta males the drastic improvement in mating success was mainly linked to the ME exposure.
Inheritance of resistance to Gibberella ear rot and deoxynivalenol contamination in five flint maize crosses
Authors: Martin Matthias , Dhillon Baldev S. , Miedaner Thomas , Melchinger Albrecht E. 
Published: October 2011

With 1 figure and 2 tablesAbstractGibberella ear rot (GER) of maize caused by Fusarium graminearum leads to contamination of grains with mycotoxins such as deoxynivalenol (DON), thus reducing the quality of food and feed. A generation means analysis was conducted to estimate gene effects influencing the resistance to GER and DON contamination in flint maize germplasm adapted to Central Europe. Five crosses of two resistant and two susceptible flint inbred lines were developed, and each cross comprised both parent lines (P1, P2) as well as the F1 and F2 generation and the first backcross to both parents (BC1‐P1, BC1‐P2). All entries were grown in four environments and artificially inoculated with F. graminearum. There was a prevalence of additive gene action, while significant dominance effects were found in only one cross for resistance to GER, but in four crosses for resistance to DON contamination. Owing to the prevalence of additive gene action, the prospects are good to improve the resistance of the flint germplasm and to accumulate more favourable gene combinations in future breeding lines.
Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer
Authors: Lim Jonathan Chee Woei , Chan Tze Khee , Ng David SW , Sagineedu Sreenivasa R , Stanslas Johnson , Wong WS Fred 
Published: October 2011

Summary1. Andrographis paniculata (Burm. f) Nees, commonly known as ‘king of bitters’, is a herbaceous plant belonging to the Family Acanthaceae. It has been widely used for centuries in Asian countries like China, India, Thailand and Malaysia for the treatment of sore throat, flu and upper respiratory tract infections.2. Andrographolide, 14‐deoxy‐11,12‐didehydroandrographolide and neoandrographolide are examples of the major labdane diterpenoids isolated from A. paniculata. These bioactive molecules have exhibited varying degrees of anti‐inflammatory and anticancer activities in both in vitro and in vivo experimental models of inflammation and cancer.3. Extensive libraries of andrographolide analogues have been synthesised mainly by modifying the α,β‐unsaturated γ‐butyrolactone moiety, the two double bonds Δ8,(17) and Δ12,(13) and the three hydroxyls at C‐3 (secondary), C‐14 (allylic) and C‐19 (primary). Many of these synthetic analogues exhibit superior anticancer activity over the naturally occurring andrographolides.4. Andrographolide and its derivatives have been shown to have anti‐inflammatory effects in experimental models of asthma, stroke and arthritis, as well as in patients with upper respiratory tract infections. Andrographolide reduces the production of cytokines, chemokines, adhesion molecules, nitric oxide and lipid mediators, probably via inhibition of the nuclear factor (NF)‐κB signalling pathway.5. The anticancer mechanisms for andrographolide include inhibition of Janus tyrosine kinases–signal transducers and activators of transcription, phosphatidylinositol 3‐kinase and NF‐κB signalling pathways, suppression of heat shock protein 90, cyclins and cyclin‐dependent kinases, metalloproteinases and growth factors, and the induction of tumour suppressor proteins p53 and p21, leading to inhibition of cancer cell proliferation, survival, metastasis and angiogenesis.6. Andrographolide drug discovery is a promising strategy for the development of a novel class of anti‐inflammatory and anticancer drugs.
Age at orchidopexy as an indicator of the quality of regional child health services
Authors: Bruijnen Christine JP , Vogels Helen DE , Beasley Spencer W 
Published: October 2011

AbstractEarly treatment for primary undescended testis (UDT) is necessary to prevent testicular degeneration and improve fertility. The general recommended age for orchidopexy is before 2 years of age. Comparing the age distribution of orchidopexy between different services may give an indirect indication of the quality of the child health services, since timely diagnosis and referral will lead to boys undergoing orchidopexy at the optimal age. This paper reviews the age distribution of boys having orchidopexies for UDT between 1997 and 2006 in the South Island of New Zealand and the state of Victoria, Australia: 64.2% of boys on the South Island and 48.0% of boys in Victoria had orchidopexies before the age of 5. There was a considerable difference in the proportions of children from 0 to 4 years and from 10 to 14 years between the two regions. No distinct trend in age was seen in either population during the period reviewed. These results show that many boys do not receive treatment for UDT at the optimal age. Age at orchidopexy may be an indicator of the quality (in terms of diagnosis, access and timeliness) of a region's paediatric surgical service and may identify where attention should be paid if earlier diagnosis and referral is to be achieved.
Investigating sentence processing and language segmentation in explaining children's performance on a sentence‐span task
Authors: Mainela‐Arnold Elina , Misra Maya , Miller Carol , Poll Gerard H. , Park Ji Sook 
Published: October 2011

AbstractBackground: Children with poor language abilities tend to perform poorly on verbal working memory tasks. This result has been interpreted as evidence that limitations in working memory capacity may interfere with the development of a mature linguistic system. However, it is possible that language abilities, such as the efficiency of sentence processing and the ability to segment language, directly influence performance on common working memory tasks.Aims: This study investigated the possible roles of sentence‐processing efficiency and the ability to segment language in children's performance on a verbal working memory task.Methods & Procedures: Participants were 37 children (aged 6;2–13;7) with varying oral language and reading abilities. Children completed a sentence‐span task to assess working memory: the Competing Language Processing Task (CLPT). In the CLPT, children determine the truth value of sentences while maintaining sentence final words in memory. Sentence‐processing efficiency was evaluated by measuring response latencies to CLPT sentence veracity judgments outside the context of the CLPT. The Elision and Blending Words subtests of the Comprehensive Test of Phonological Processing were used to measure the ability to segment and combine units of language.Outcomes & Results: Children's ability to segment words into smaller units (Elision) was a significant predictor of word recall on the CLPT, which is commonly assumed to reflect working memory capacity. Sentence processing latency did not reach significance as a unique predictor.Conclusions & Implications: Individual differences on the sentence‐span task are partly explained by the ability to segment language into smaller units. Future studies should further consider the metalinguistic and metacognitive demands of tasks used to measure working memory. If metalinguistic abilities directly impact performance on working memory tasks, the utility of working memory theories in explaining individual differences in language abilities is reduced. Inferences that link ‘working memory capacity’ to language ability become circular. One clinical implication of such a result would be that appropriate intervention strategies may not involve focusing on working memory capacity, but rather on building language skills, including metalinguistic knowledge, which in turn should directly improve children's processing capacities.
Exchange students crossing language boundaries in clinical nursing practice
Authors: Myhre K. 
Published: October 2011

MYHRE K. (2011) Exchange students crossing language boundaries in clinical nursing practice. International Nursing Review58, 428–433Aim:  This article examines challenges and learning outcomes for nursing students from a Central European university of applied sciences who completed 3 months of clinical practice in Norway. The clinical practice was supervised in English by Norwegian nurses and nursing teachers. English is not the primary language in any of the countries.Background:  Increases in global migration have contributed to the need for an international dimension in nursing education. Personal mobility is a crucial part of the European Union's goal of becoming a knowledge society. Clinically based experiences pose challenges that are additional to and often more complex than traditional course‐based experiences. Students who come from a non‐English‐speaking country for clinical practice in Norway face challenges regarding language. Accepting incoming students is a way of achieving higher quality and more relevant education in nursing.Findings:  The study shows that clinical practice in a foreign country gives added value compared with clinical practice at home. Greater self‐confidence and understanding of core concepts in nursing is described by the participants. Language differences are not regarded as a problem but as a way of developing personal and professional competence. The ability to compare healthcare systems in the two counties is important in developing competencies in nursing.
Many paths lead to nursing: factors influencing students' perceptions of nursing
Authors: Cowin L.S. , Johnson M. 
Published: October 2011

COWIN L.S. & JOHNSON M. (2011) Many paths lead to nursing: factors influencing students' perceptions of nursing. International Nursing Review58, 413–419Background:  A diverse group of students is being recruited to nursing programmes worldwide, although little research has identified the effect of this diversity. Contemporary knowledge of the qualities of nurses and how they vary with demographic and other factors may assist in the retention of nursing students.Aim:  The aim of this study is to explore student nurses' perceptions of the qualities of nurses and how these differ with age, country of birth, gender, healthcare experience and mode of entry to the nursing programme.Methods:  Using a descriptive comparative design, 676 nursing students in their first week of a Bachelor of Nursing programme participated (77% response). Participants completed a survey noting demographic data such as age, gender, healthcare experience, country of birth, nursing programme entry method and attributes of nurses from the valid and reliable Qualities of Nursing Scale (QoN).Results:  Overall, the students confirmed their agreement with the 12 items of the QoN and rated good listening skills as the most important quality for a nurse rather than Caring or Helping. Male participants and participants born overseas demonstrated the lowest mean scores on most qualities, suggesting less agreement with the qualities.Discussion:  The recruitment of students to university needs to continue to support disparate entry pathways. Students with more life experience (older students) or health experience may be more likely to complete nursing courses and to be retained within health services. Qualities of nurses may be changing to reflect modern perceptions of nurses with a shift away from the focus on caring.
Investigating the roles of perceived playfulness, resistance to change and self‐management of learning in mobile English learning outcome
Authors: Huang Rui‐Ting , Jang Syh‐Jong , Machtmes Krisanna , Deggs David 
Published: October 2011

AbstractAlthough there is a growing interest in mobile learning, there are limited studies that focus on student knowledge acquisition. As applications and usages of mobile technology have become more and more accepted, it is important and meaningful that researchers and practitioners of mobile learning understand the potential factors that could influence learning outcomes. Accordingly, the primary purpose of this study was to investigate the roles of mobile technology playfulness, users' resistance to change and self‐management of learning in mobile English learning outcomes (MELOs). A case study approach was utilized in this study mainly because the questions of interests were closely related to the usage of electronic dictionaries and their effects on mobile learning outcomes. The participants of this study were all undergraduate students from 10 undergraduate programs of the center for general education at one university in Southern Taiwan. A total of n = 167 undergraduate students with experience using an electronic dictionary to learn English participated in this study. The study results indicated that perceived playfulness and self‐management of learning had positive influences on MELO and that users' resistance to change was negatively associated with MELO.Practitioner NotesWhat is already known about this topic
Key roles of mobile devices in learning activities.
Limitations of mobile devices.
The importance of mobile learning evaluation and outcome.
What this paper adds
Investigating the role of perceived playfulness in mobile learning outcome.
Investigating the influence of resistance to change on mobile learning outcome.
Investigating the effect of self‐management of learning on mobile learning outcome.
Evaluation of mobile learning.
Implications for practice and/or policy
The integration of technology into learning environments could play a key role in enhancing learning effectiveness and efficiency.
Timely support could be a useful way to help learners minimize resistance to using mobile devices and maximize adoption of mobile technology.
It should be noted that teachers should suggest that learners with better self‐management of learning capabilities adopt mobile learning so that the learners can realize more positive learning outcomes.
NEIGHBOURHOOD COMPOSITION AND ECONOMIC PROSPECTS: A LONGITUDINAL STUDY IN THE NETHERLANDS
Authors: MUSTERD SAKO , DE VOS SJOERD , DAS MARJOLIJN , LATTEN JAN 
Published: October 2011

ABSTRACT‘How does the “social” and “cultural” neighbourhood composition impact on the economic prospects of its inhabitants?’ We addressed this question, while using a new longitudinal dataset. We analysed the individual income changes between 1999 and 2005 of all Dutch 18–49 year‐olds (subdivided in four strata) who stayed in the same neighbourhood throughout the period while focusing on the role of neighbourhood after controlling for a range of individual variables. The impact of neighbourhood contexts is statistically significant, yet limited compared to the impact of individual characteristics. Social context – neighbourhood median income and income mix – turned out to be most relevant in terms of neighbourhood impact. Higher median incomes and more income mix in the neighbourhood have significant positive effects on individual income development.
How does temporal preparation speed up response implementation in choice tasks? Evidence for an early cortical activation
Authors: Tandonnet Christophe , Davranche Karen , Meynier Chloé , Burle Borís , Vidal Franck , Hasbroucq Thierry 
Published: October 2011

AbstractWe investigated the influence of temporal preparation on information processing. Single‐pulse transcranial magnetic stimulation (TMS) of the primary motor cortex was delivered during a between‐hand choice task. The time interval between the warning and the imperative stimulus varied across blocks of trials was either optimal (500 ms) or nonoptimal (2500 ms) for participants' performance. Silent period duration was shorter prior to the first evidence of response selection for the optimal condition. Amplitude of the motor evoked potential specific to the responding hand increased earlier for the optimal condition. These results revealed an early release of cortical inhibition and a faster integration of the response selection‐related inputs to the corticospinal pathway when temporal preparation is better. Temporal preparation may induce cortical activation prior to response selection that speeds up the implementation of the selected response.
Cells, biomarkers, and post‐traumatic stress disorder: evidence for peripheral involvement in a central disease
Authors: Andrews James A. , Neises Kameran D. 
Published: October 2011

J. Neurochem. (2012) 120, 26–36.AbstractPost‐traumatic stress disorder (PTSD) is a complicated CNS syndrome. Looking beyond the CNS, recent studies suggest that peripheral blood mononuclear cells could cause and/or exacerbate PTSD. This review summarizes the literature, describes associations between circulating peripheral blood cells and PTSD, proposes a novel mechanism, and analyzes several biomarkers that appear to associate with PTSD symptoms. Several experimental animal models have shown that peripheral blood mononuclear cell activity can cause hippocampal volume loss and PTSD‐like symptoms. Data from these models suggest that a traumatic event and/or traumatic events can trigger peripheral cells to migrate, mediate inflammation, and decrease neurogenesis, potentially leading to CNS volume loss. Biomarkers that associate with PTSD symptoms have the potential to differentiate PTSD from traumatic brain injury, but more work needs to be done. Research examining the mechanism of how traumatic events are linked to peripheral blood mononuclear cell functions and biomarkers may offer improved diagnoses and treatments for PTSD patients.