bluuebunny/crossref_metadata_2025_split huggingface dataset:
Origin of the Activity of Electrochemical Ozone Production Over Rutile PbO2 Surfaces
Authors: Jiang Jin‐Tao , Guo Zhongyuan , Deng Shao‐Kang , Jia Xue , Liu Heng , Xu Jiang , Li Hao , Cheng Li‐Hua 
Published: May 2024

AbstractOzonation water treatment technology has attracted increasing attention due to its environmental benign and high efficiency. Rutile PbO2 is a promising anode material for electrochemical ozone production (EOP). However, the reaction mechanism underlying ozone production catalyzed by PbO2 was rarely studied and not well‐understood, which was in part due to the overlook of the electrochemistry‐driven formation of oxygen vacancy (OV) of PbO2. Herein, we unrevealed the origin of the EOP activity of PbO2 starting from the electrochemical surface state analysis using density functional theory (DFT) calculations, activity analysis, and catalytic volcano modeling. Interestingly, we found that under experimental EOP potential (i. e., a potential around 2.2 V vs. reversible hydrogen electrode), OV can still be generated easily on PbO2 surfaces. Our subsequent kinetic and thermodynamic analyses show that these OV sites on PbO2 surfaces are highly active for the EOP reaction through an interesting atomic oxygen (O*)‐O2 coupled mechanism. In particular, rutile PbO2(101) with the “in‐situ” generated OV exhibited superior EOP activities, outperforming the (111) and (110) surfaces. Finally, by catalytic volcano modeling, we found that PbO2 is close to the theoretical optimum of the reaction, suggesting a superior EOP performance of rutile PbO2. All these analyses are in good agreement with previous experimental observations in terms of EOP overpotentials. This study provides the first volcano model to explain why rutile PbO2 is among the best metal oxide materials for EOP and provides new design guidelines for this rarely studied but industrially promising reaction.
A family of single‐phase boost AC‐AC converters based on impedance network cells with symmetric bipolar operation
Authors: Fathipour Babak , Mousavi Seyyed Mohammad Javad , Babaei Ebrahim 
Published: May 2024

SummaryIn this paper, a family of single‐phase boost AC‐AC converters based on impedance network cells with symmetric bipolar operation is proposed. The proposed converters exhibit a range of voltage gains as a result of non‐inverting and inverting boost operations, which are influenced by the input voltage and various impedance source cells. The converters leverage inherent commutation to address the commutation problem without requiring snubber circuits and safe commutation strategy. Additionally, high‐speed switching is achieved by preventing power MOSFETs' body diode conduction and related poor reverse recovery issues. The design incorporates a simple and flexible switching strategy to produce step‐change frequency at the output, using only four switches to achieve both step‐changed frequency operation and output voltage regulation. Furthermore, by reducing the total stored energy of passive components, the proposed converters effectively decrease volume, weight, and cost. The operational modes of the converters are elucidated, and their key relationships are summarized in tabular format. Finally, experimental validation through a laboratory prototype confirms the performance accuracy of the proposed converters at frequencies 25, 50, and 100 Hz.
Assessing EPO stability in urine and comparing recombinant EPO detectability in matched urine, venous serum, and capillary serum following a controlled epoetin alfa administration
Authors: Miller Geoffrey D. , Goodrum Jenna M. , Crouch Andre K. , Eichner Daniel 
Published: May 2024

AbstractThe instability of erythropoietin receptor agonists (ERAs, i.e., EPO) in urine presents a challenge to their detectability in doping control samples; however, this issue is not often seen in blood (serum) samples. With the anti‐doping field beginning to transition into alternative blood collection technologies, it is important to understand recombinant EPO (rEPO) detectability in serum samples collected from one such capillary collection device, the Tasso+ SST. Twelve individuals were administered a single, 40 IU/kg dose of rEPO (epoetin alfa, EPOGEN®). Following administration, matched urine, venous serum, and capillary serum samples were concurrently collected. Urine aliquots were subject to various storage times and temperatures mimicking shipping conditions of doping control urine samples to assess EPO stability, while other urine aliquots, venous serum, and capillary serum aliquots were frozen until analysis to understand rEPO detectability across all three matrices. EPO and rEPO instability was identified in urine collected from 8 of 12 participants, especially in aliquots stored at room temperature and 37°C. In some of these unstable samples, rEPO was still detectable, while in others, no recombinant nor endogenous EPO was detectable and would have resulted in negative sample reports. Analyzing the concurrently collected urine, venous, and capillary serum samples, rEPO detectability was identical across the three matrices. In most cases, rEPO was detectable for at least 168 h post‐administration. Noting greater stability in blood compared with urine, it is recommended that anti‐doping authorities utilize this novel capillary serum collection technology to improve overall ERA detectability in doping control samples.
Field validation of an eDNA assay for nutria illuminates a role in invasive species management
Authors: Coster Stephanie S. 
Published: May 2024

AbstractNutria, or coypu (Myocastor coypus), are invasive semi‐aquatic rodents present across the United States, Europe, and Asia. Despite successful eradication efforts in certain areas, nutria have resurged in the mid‐Atlantic USA, underscoring the need for advanced monitoring tools. Environmental DNA (eDNA) has emerged as a promising technique for species detection and monitoring. Here, an eDNA assay for nutria using qPCR was field‐validated in Virginia, USA, showcasing its potential as a tool for post‐eradication monitoring. The findings reveal an association between water levels and detection of nutria eDNA, highlighting the importance of water levels in nutria behavior. A painted turtle assay was introduced to confirm nutria absence and demonstrate the potential of passive sampling. The study showcases the sensitivity and efficiency of eDNA assays, emphasizing their value for monitoring and verifying invasive species eradication.
Pulmonary artery denervation versus conventional therapies for PAH: a systematic review and updated network meta‐analysis
Authors: Wu Xiaoyu , Wang Xiang , Zhang Longyao , Pan Zoucheng , Chen Feng , Chen Shao‐liang , Kan Jing , Wei Yongyue 
Published: May 2024

AbstractAimsA recent guideline presented by the ESC Congress in 2022 had indicated a novel therapy targeted at pulmonary artery hypertension, known as pulmonary artery denervation (PADN), which get inspired from a laboratorial trial that could lowering the pulmonary artery pressure through the intervention on the animals. Our aim is to conduct a network meta‐analysis to compare the efficacy and safety of PADN from six aspects with the current conventional therapies.Methods and resultsAccording to the PRISMA guidance, databases including Ovid, ClinicalTrials.gov, Medline, Embase, and PubMed were searched from inception to 22 August 2023, along with a full assessment of the previous five meta‐analyses. Data were extracted and curated for Bayesian network meta‐analysis. The primary outcome was the change in the 6‐min walking distance (6MWD) from baseline with a secondary outcome called change in mean pulmonary artery pressure (mPAP) from baseline. The four safety outcomes included risk of clinical worsening, hospitalization, mortality and severe adverse events (SAEs). The comparison is structured on a contrast model based on 65 randomized controlled trials (RCTs) on PADN and the other conventional mainstream drugs. PADN had a better effect in improving 6MWD than Placebo (−77.76 m, 95% CI: −102.04 to −54.34 m), Macitentan (−65.32 m, 95% CI: −95.34 to −36.1 m), Bosentan (−64.5 m, 95% CI: −94.7 to −35.07 m), Iloprost (−62.66 m, 95% CI: −99.48 to −27.13 m), Oxygen (−62.42 m, 95% CI: −100.01 to −25.78 m), Treprostinil (−62.01 m, 95% CI: −89.04 to −35.61 m), Riociguat (−60.59 m, 95% CI: −86.11 to −35.98 m), Selexipag (−47.2 m, 95% CI: −85.61 to −10.19 m), Sildenafil (−44.92 m, 95% CI: −74.43 to −16.15 m), or Sitaxsentan (−39.53 m, 95% CI: −78.99 to −0.76 m). PADN had a better antihypertensive effect than placebo and showed statistical significant lower risks to induce clinical worsening and re‐hospitalization than treprostinil, riociguat, and placebo groups. No statistically significant difference in risk of mortality and severe adverse events was observed between PADN versus the other interventions.ConclusionsCompared with 16 types of conventional therapies and Placebo, PADN has advantage over nine single therapies and Placebo in improving 6MWD and appears to be better than two types of dual‐drug combined therapies while with no statistical significance. PADN shows a favourable antihypertensive effect on mPAP and has a lower risk to trigger clinical worsening or hospitalization, while its risk on mortality and severe adverse events is still inconclusive.
Methanol gel electrophoresis: Separation of human fast and slow myosin light chain 1 and other myofibrillar protein isoforms on a single gel format
Authors: Reiser Peter J. , Belevych Natalya , Shope Logan , Hanaoka Beatriz 
Published: May 2024

AbstractThis report describes a novel sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS–PAGE) resolving gel format that consistently yields the electrophoretic separation of the fast and slow isoforms of human sarcomeric myosin light chain 1 (MLC1). The inclusion of methanol as a constituent of the resolving gel impacted the electrophoretic mobility of proteins across a broad range of molecular masses. There was greater separation of the fast and slow isoforms of human MLC1, as well as separation and high resolution of fast and slow isoforms of the three myosin heavy chain isoforms that are expressed in human skeletal muscle on the same gel format. Furthermore, the same resolving gel format substantially altered the electrophoretic mobility of at least one isoform of tropomyosin in human striated muscle. It is possible that the inclusion of methanol in SDS–PAGE resolving gels could improve the separation of other proteins that are expressed in muscle and in other tissues and cell types.
An immuno‐northern technique to measure the size of dsRNA byproducts in in vitro transcribed RNA
Authors: Clark Nathaniel E. , Schraut Matthew R. , Winters Roger A. , Kearns Kelley , Scanlon Thomas C. 
Published: May 2024

AbstractDouble‐stranded RNA is an immunogenic byproduct present in RNA synthesized with in vitro transcription. dsRNA byproducts engage virus‐sensing innate immunity receptors and cause inflammation. Removing dsRNA from in vitro transcribed messenger RNA (mRNA) reduces immunogenicity and improves protein translation. Levels of dsRNA are typically 0.1%–0.5% of total transcribed RNA. Because they form such a minor fraction of the total RNA in transcription reactions, it is difficult to confidently identify discrete bands on agarose gels that correspond to the dsRNA byproducts. Thus, the sizes of dsRNA byproducts are largely unknown. Total levels of dsRNA are typically assayed with dsRNA‐specific antibodies in ELISA and immuno dot‐blot assays. Here we report a dsRNA‐specific immuno‐northern blot technique that provides a clear picture of the dsRNA size distributions in transcribed RNA. This technique could complement existing dsRNA analytical methods in studies of dsRNA byproduct synthesis, dsRNA removal, and characterization of therapeutic RNA drug substances.
An investigation of neuropsychiatric symptoms, contextual factors, and antidepressant treatment as risk factors for dementia development in people with mild cognitive impairment
Authors: Willmott Ruth , Martin West Isobel , Yung Paul , Giri Shankar Vidya , Perera Gayan , Tsamakis Konstantinos , Stewart Robert , Mueller Christoph 
Published: May 2024

AbstractBackgroundWhile some people with mild cognitive impairment (MCI) progress to dementia, many others show no progression. The aim of this study was to identify factors associated with risk of dementia development in this population.MethodA large naturalistic retrospective cohort study was assembled from mental healthcare records in a south London catchment. Patients were selected at first recorded diagnosis of MCI and subsequent dementia diagnosis was ascertained from case notes or death certificate, excluding those with dementia diagnoses and deaths within 6 months of MCI diagnosis. A range of demographic and clinical characteristics were ascertained around MCI diagnosis and Cox proportional hazards models were used to investigate independent predictors of dementia, focussing on neuropsychiatric symptoms, contextual factors, and antidepressant treatment.ResultsOf 2250 patients with MCI, 236 (10.5%) developed dementia at least 6 months after MCI diagnosis. Aside from older age, lower cognitive function, and activities of daily living impairment, impaired social relationships and recorded loneliness were associated with a higher risk of developing dementia. Patients of Black (compared to White) ethnicity were at a lower risk. For depression and antidepressant receipt, only tricyclic use compared to no antidepressant use was associated with an increased dementia risk.ConclusionsNo evidence was found for co‐morbid affective disorders or different antidepressant classes as risk factors for dementia development following MCI diagnosis, but loneliness and social impairment were independent predictors and would be worth evaluating as targets for interventions to delay progression.
Multiple primary lung cancer: Updates and perspectives
Authors: Wang Ziqi , Zhang Quncheng , Wang Chaoyang , Herth Felix J. F. , Guo Zhiping , Zhang Xiaoju 
Published: May 2024

AbstractManagement of multiple primary lung cancer (MPLC) remains challenging, partly due to its increasing incidence, especially with the significant rise in cases of multiple lung nodules caused by low‐dose computed tomography screening. Moreover, the indefinite pathogenesis, diagnostic criteria, and treatment selection add to the complexity. In recent years, there have been continuous efforts to dissect the molecular characteristics of MPLC and explore new diagnostic approaches as well as treatment modalities, which will be reviewed here, with a focus on newly emerging evidence and future perspectives, hope to provide new insights into the management of MPLC and serve as inspiration for future research related to MPLC.
Resorbable engineered barrier membranes for oral surgery applications
Authors: Balducci Cristian , Zamuner Annj , Todesco Martina , Bagno Andrea , Pasquato Antonella , Iucci Giovanna , Bertelà Federica , Battocchio Chiara , Tortora Luca , Sacchetto Luca , Brun Paola , Bressan Eriberto , Dettin Monica 
Published: May 2024

AbstractPopulation aging, reduced economic capacity, and neglecting the treatments for oral pathologies, are the main causal factors for about 3 billion individuals who are suffering from partial/total edentulism or alveolar bone resorption: thus, the demand for dental implants is increasingly growing. To achieve a good prognosis for implant‐supported restorations, adequate peri‐implant bone volume is mandatory. The Guided Bone Regeneration (GBR) technique is one of the most applied methods for alveolar bone reconstruction and treatment of peri‐implant bone deficiencies. This technique involves the use of different types of membranes in association with some bone substitutes (autologous, homologous, or heterologous). However, time for bone regeneration is often too long and the bone quality is not simply predictable. This study aims at engineering and evaluating the efficacy of modified barrier membranes, enhancing their bioactivity for improved alveolar bone tissue regeneration. We investigated membranes functionalized with chitosan (CS) and chitosan combined with the peptide GBMP1α (CS + GBMP1α), to improve bone growth. OsseoGuard® membranes, derived from bovine Achilles tendon type I collagen crosslinked with formaldehyde, were modified using CS and CS + GBMP1α. The functionalization, carried out with 1‐ethyl‐3‐(3 dimethylaminopropyl)carbodiimide and sulfo‐N‐Hydroxysuccinimide (EDC/sulfo‐NHS), was assessed through FT‐IR and XPS analyses. Biological assays were performed by directly seeding human osteoblasts onto the materials to assess cell proliferation, mineralization, gene expression of Secreted Phosphoprotein 1 (SPP1) and Runt‐Related Transcription Factor 2 (Runx2), and antibacterial properties. Both CS and CS + GBMP1α functionalizations significantly enhanced human osteoblast proliferation, mineralization, gene expression, and antibacterial activity compared to commercial membranes. The CS + GBMP1α functionalization exhibited superior outcomes in all biological assays. Mechanical tests showed no significant alterations of membrane biomechanical properties post‐functionalization. The engineered membranes, especially those functionalized with CS + GBMP1α, are suitable for GBR applications thanks to their ability to enhance osteoblast activity and promote bone tissue regeneration. These findings suggest a potential advancement in the treatment of oral cavity problems requiring bone regeneration.
Enhanced water electrolysis by construction and control of nickel (cobalt) phosphide/metal interface
Authors: Xia Shuang , Fu Xiao , Wang Bin , Wang Yi , Liu Zhongqing 
Published: May 2024

AbstractUsing cobalt sulfate and nickel sulfate as main electrolytes, ammonium sulfate as an auxiliary electrolyte and buffer agent, and cheap iron pieces (FP) as the substrates, nickel and/or cobalt phosphide/metal heterogeneous catalytic electrode (M2P/M/FP) was grown on the substrate in situ by electrodeposition followed by low temperature phosphating. M2P/M/FP functioned as a good bifunctional electrode for HER and OER in 1 mol/L KOH, where Co2P/Co/FP needed an overpotential of 52 and 288 mV, and (NC)2P/(NC)/FP required that of 75 mV and 293 mV to afford 10 mA/cm2. Previous similar studies often ignored the role of metal and only considered the water electrolysis catalysis of metal phosphide. In this research, it was clarified that for water electrolysis, the essence of high catalysis activity of the M2P/M/FP electrode was the electronic interaction between metal and metal phosphide.
Hydrogen peroxide electrosynthesis using commercial carbon blacks as catalysts: the influence of surface properties and adsorption performance
Authors: Han Xinyu , Yuan Shiyu , Zhu Zhaolian , Mei Jiawen , Huang Qiyuan , Ji Liya , Wang Hailing 
Published: May 2024

AbstractBACKGROUNDSurface properties and adsorption performance of carbon materials play a crucial role in the electrochemical two‐electron oxygen reduction to produce H2O2. However, there is still a lack of in‐depth research on commercial carbon blacks in this area. Herein, four typical commercial carbon blacks (Acetylene black (AB), Ketjen black EC 600JD, Vulcan XC 72 and Black Pearls 2000) were used as cathode catalysts to generate H2O2. Surface chemistry and pore structure of electrodes of the four carbon blacks were systematically characterized, and their effects on H2O2 adsorption, electrochemical generation and degradation were investigated.RESULTSAmong the four carbon blacks, AB has the highest content of C–O–C/COOH and CO, which are active groups catalyzing the two‐electron oxygen reduction reaction to generate H2O2. AB has the lowest level of defects and highest degree of graphitization, and AB‐modified graphite felt electrode (AB‐Ele) has the largest average pore diameter, smallest specific surface area and smaller charge transfer resistance. H2O2 production using AB‐Ele is the largest and reaches 567.7 mg L−1 at 180 min under a current density of 5 mA cm−2, and only decreases by 17.6% after 10 repeated uses.CONCLUSIONOverall, rich oxygen‐containing functional groups such as C–O–C, COOH and CO, high degree of graphitization, suitable surface area and porosity as well as weak H2O2 adsorption performance are beneficial for the two‐electron oxygen reduction reaction to generate H2O2. AB‐modified graphite felt electrode exhibits good catalytic activity and reusability in H2O2 electrosynthesis, demonstrating promising application prospects. © 2024 Society of Chemical Industry (SCI).
Peripheral T‐cell lymphoma invasion of the liver: The underappreciated hypoechoic periportal cuffing on ultrasound—A case report and literature review
Authors: He Fen , Wang Rui , Li Lu , Yi Heng , Chen Zhong 
Published: May 2024

AbstractLiver involvement in lymphoma often manifests as nonoccupying diffuse infiltration, posing challenges in distinguishing it from primary liver disorder. Herein, we present the case of a 21‐year‐old female who underwent two separate diagnoses within a nine‐month interval before being ultimately diagnosed with peripheral T‐cell lymphoma, not otherwise specified. Our review of this case identified an ultrasound imaging feature, the hypoechoic periportal cuffing. When combined with associated increased lymphocyte count and liver enlargement, it can serve as a noninvasive suggestion for malignant disorders, in particular hemic and lymphatic diseases.
Factors associated with predoctoral and graduate dental students’ intention to care for elderly patients: A cross‐sectional study
Authors: Sharka Rayan 
Published: May 2024

AbstractObjectivesAgeism among pre‐doctoral and graduate dental students may reduce their propensity to provide dental treatment to elderly patients leading to substandard healthcare for this population. This study evaluated the impact of perceived ageism constructs and geriatric dentistry education on the intention of pre‐doctoral and graduate students to provide dental care for elderly patients.MethodsA questionnaire was applied to collect the data for this cross‐sectional study from pre‐doctoral students in their clinical years and graduate students in their internship year (N = 201). A total of 183 completed responses were received, and the response rate was 91%. Hierarchical regression analysis was performed to determine the incremental effects of perceived ageism constructs and geriatric dentistry education on the intention to provide dental care for elderly patients.ResultsGeriatric dental education (B = 0.328, t = 3.826, p < 0.001) and patients’ low compliance (B = 0.503, t = 4.658, p < 0.001) were significantly positive predictors of pre‐doctoral and graduate students’ intentions to care for elderly patients. Also, negative attitudes toward the lives of elderly people have a substantial adverse effect on the intention of care for this population (B = −0.225, t = −2.206, p = 0.029). Cronbach's alpha for the scale constructs ranged from 0.738 to 0.886.ConclusionsAdvanced geriatric training may cultivate pre‐doctoral and graduate students’ deeper understanding and recognition of the intellectual and practical benefits that might arise from offering dental care to elderly people.