bluuebunny/crossref_metadata_2025_split huggingface dataset:
Negative Regulation of IRF7 Activation by Activating Transcription Factor 4 Suggests a Cross-Regulation between the IFN Responses and the Cellular Integrated Stress Responses
Authors: Liang Qiming , Deng Hongying , Sun Chiao-Wang , Townes Tim M. , Zhu Fanxiu 
Published: December 2010

Abstract
Cells react to viral infection by exhibiting IFN-based innate immune responses and integrated stress responses, but little is known about the interrelationships between the two. In this study, we report a linkage between these two host-protective cellular mechanisms. We found that IFN regulatory factor (IRF)7, the master regulator of type I IFN gene expression, interacts with activating transcription factor (ATF)4, a key component of the integrated stress responses whose translation is induced by viral infection and various stresses. We have demonstrated that IRF7 upregulates ATF4 activity and expression, whereas ATF4 in return inhibits IRF7 activation, suggesting a cross-regulation between the IFN response and the cellular integrated stress response that controls host innate immune defense against viral infection.
IgM Production by Bone Marrow Plasmablasts Contributes to Long-Term Protection against Intracellular Bacterial Infection
Authors: Racine Rachael , McLaughlin Maura , Jones Derek D. , Wittmer Susan T. , MacNamara Katherine C. , Woodland David L. , Winslow Gary M. 
Published: December 2010

Abstract
IgM responses are well known to occur early postinfection and tend to be short-lived, which has suggested that this Ig does not significantly contribute to long-term immunity. In this study, we demonstrate that chronic infection with the intracellular bacterium Ehrlichia muris elicits a protective, long-term IgM response. Moreover, we identified a population of CD138highIgMhigh B cells responsible for Ag-specific IgM production in the bone marrow. The IgM-secreting cells, which exhibited characteristics of both plasmablasts and plasma cells, contributed to protection against fatal ehrlichial challenge. Mice deficient in activation-induced cytidine deaminase, which produce only IgM, were protected against fatal ehrlichial challenge infection. The IgM-secreting cells that we have identified were maintained in the bone marrow in the absence of chronic infection, as antibiotic-treated mice remained protected against challenge infection. Our studies identify a cell population that is responsible for the IgM production in the bone marrow, and they highlight a novel role for IgM in the maintenance of long-term immunity during intracellular bacterial infection.
A Post Traumatic Stress Disorder Ethical Update
Authors: Striefel Sebastian “Seb” 
Published: December 2010

Abstract
Post traumatic stress disorder (PTSD) is a complex condition with a variety of potential causes and symptoms, and it requires multifaceted treatment. Practitioners are cautioned to take great care in the informed consent process to ensure that clients know their treatment options, the level of support, and pros and cons of each option before giving consent. Practitioners need to be familiar with both the clinical and research data when developing a rationale and treatment approach that is individualized for the specific client. Moreover, practitioners should be competent in diagnosing a wide variety of conditions that are comorbid with PTSD and should ensure that they can legally make such a diagnosis and provide treatment for the specific conditions from which the client suffers. In addition, it is strongly recommended, if not legally required, that practitioners have an appropriate background in a mental health discipline so they are competent to help a client work through the traumas, symptoms, and side effects experienced by the client before undertaking the treatment of those suffering from PTSD.
Whole-Body Breathing III: Clinical Application/Implementation
Authors: van Dixhoorn Jan 
Published: December 2010

Abstract
This article is the third in a three-part series on whole-body breathing. The author proposes a process model, in which breath training, muscle relaxation, and lifestyle changes are customized as the therapist explores the patient's response to initial interventions. This process model is useful for many cases in medical practice, where clear and specific causes cannot be identified for symptoms and no clear treatment is known. The article provides a case history of a 38-year-old man who sustained whiplash injuries in a motor vehicle accident and subsequently developed cardiovascular problems (congestive cardiomyopathy). Subsequent cardiac rehabilitation proceeded poorly, but he responded positively when the whole-body breathing approach was added, with improved ejection fraction and improved tolerance for activity. This case study illustrates the process of adjusting interventions to the individual's condition.
Biofeedback Certification Institute of America: Educators Who Have Made a Difference (Part 2)
Authors: Shaffer Fred , Crawford Judy 
Published: December 2010

Abstract
The Biofeedback Certification Institute of America values its partnership with the dedicated educators who teach biofeedback and neurofeedback to our certificants. This article is the second in a series that introduces the dedicated educators who have helped us succeed in our mission to protect the welfare of biofeedback consumers, to provide credibility to biofeedback practitioners, and to advance the field of biofeedback. This article also reports on the international growth of biofeedback and neurofeedback training programs.
Psykinetics and Biofeedback: Abhinav Bindra Wins India's First-Ever Individual Gold Medal in Beijing Olympics
Authors: Harkness Timothy 
Published: December 2010

Abstract
The author describes sports psychophysiology interventions with the Indian Olympic gold medal winner, Abhinav Bindra, who performed in the air rifle event at the 2008 Beijing Olympics. The article proposes an evolutionary psykinetics approach, accenting “psykinetic states”—postural patterns linked to dominant personality characteristics. The interventions included biofeedback training using respiration, thermal biofeedback, electro-dermal biofeedback, neurofeedback, and heart rate variability. Training objectives included assisting the athlete to remain extremely calm (to avoid any trembling during sighting) while also remaining mentally alert and reactive. The neurofeedback training was customized to this athlete, and the breathing interventions included training tolerance for extended breath holds, because athletes shoot during a suspension of respiration for stability in sighting. Chiropractic manipulation and muscle activation completed the training regimen.
Resilience Training for Army ROTC Cadets: Both Pre- and Postdeployment Soldiers
Authors: Haney Maureen 
Published: December 2010

Abstract
This article describes a performance enhancement/resilience training program developed and implemented for both pre- and postdeployment ROTC cadets at California State University, Fullerton. The program integrates a psychophysiological stress profile, multimodal biofeedback training, and a skills-based group educational program to modulate stress reactivity and promote autonomic nervous system flexibility. Heart rate variability biofeedback training receives special emphasis. The impetus for the program and practical guidelines for using biofeedback with military personnel are presented.
Serendipity and the Subdural Hematoma
Authors: Gunkelman Jay 
Published: December 2010

Abstract
Mild traumatic brain injury is often missed in the course of treating other injuries. This failure to identify the brain injury can be critically important, even life threatening. This report shows one such case in which the brain injury was overlooked, possibly because of the differential effect of age on the severity of the damage incurred from what appeared to be a mild trauma. Distant to the time of the injury, deficits in speech fluency and word finding led the individual to seek further evaluation, and imaging studies revealed a large subdural hematoma. CT scan images are included.
Return to Baseline: Psychophysiological Treatment of Postconcussive Symptoms in Combat-Injured Soldiers With Mild Traumatic Brain Injury and Comorbid Post Traumatic Stress Disorder
Authors: Wilson Joan L. 
Published: December 2010

Abstract
The experience of providing self-regulating therapy to combat-injured infantry soldiers at Madigan Army Medical Center is rich in lessons and potential benefits. “Wounded Warriors” from Operation Iraqi Freedom/Operation Enduring Freedom (OIF/OEF) deployments with prolonged somatic symptoms of chronic traumatic headache, disordered sleep, cognitive and affective deficits, and autonomic hyperarousal are assessed in the Neurology Service. The Psychophysiology Clinic is an embedded biobehavioral treatment program within the Neurology Service and provides biofeedback-assisted therapies.
The Cancer Journey
Authors: Inman Alice W. 
Published: December 2010

Abstract
Cancer is the second leading cause of death in America. Because the majority of cancer patients today survive at least 5 years, cancer can be reconceptualized as a chronic illness. A diagnosis of cancer and subsequent treatment brings physical, emotional, and cognitive changes and challenges. Psycho-oncology is a relatively recent discipline that assists patients in coping with these changes. This article examines the experience of the human being facing cancer, and the potential role for behavioral professionals and biofeedback practitioners in assisting the cancer patient. There are certain periods during the cancer journey that appear to be more challenging. Biofeedback can assist patients in coping with these challenges.
Effects of Heart Rate Variability Coherence Biofeedback Training and Emotional Management Techniques to Decrease Music Performance Anxiety
Authors: Thurber Myron R. , Bodenhamer-Davis Eugenia , Johnson Mark , Chesky Kris , Chandler Cynthia K. 
Published: December 2010

AbstractDue to the prevalence of music performance anxiety and the emergence of new biofeedback technologies used to decrease anxiety, student musicians were recruited to participate in an experimental repeated-measures study to identify effects of heart rate variability coherence biofeedback training and emotional self-regulation techniques on music performance anxiety and music performance. Fourteen students were assigned randomly to a treatment or control group following a 5-minute unaccompanied baseline performance. Treatment group participants received 4–5 heart rate variability training sessions of 30–50 minutes each. Training included bibliotherapy, computerized heart rate variability biofeedback training, emotional regulation exercises, and use of a portable heart rate variability training device. Measures included the State-Trait Anxiety Inventory, Performance Anxiety Inventory, Flow State Scale, average heart rate, and heart rate variability. Quade's rank-transformed analysis of covariance was used to evaluate treatment and no-treatment group comparisons. Combined music performance anxiety scores showed statistically significant improvement at a p  =  .05 level with a large effect size of ηp2  =  .320. State anxiety measurement showed a large effect size of ηp2  =  .291. The Performance Anxiety Inventory showed a large effect size of ηp2  =  .149. Heart rate showed a large effect size of ηp2  =  .143. Heart rate variability showed statistical significance at p  =  .001 level and a large effect size of ηp2  = .698. The treatment group average subjective decrease in music performance anxiety was 71%, and the treatment group average subjective improvement in performance was 62%. This study demonstrated statistical and practical/clinical significance of a relatively quick and inexpensive biofeedback training that had a large effect on decreasing mental, emotional, and physiological aspects of music performance anxiety and subjective improvement of performance for university students.
Arousal and Identity: Thoughts on Neurofeedback in Treatment of Developmental Trauma
Authors: Fisher Sebern F. 
Published: December 2010

Abstract
This article addresses the issue of arousal in developmental trauma. The article suggests that emotional disturbance can be seen as a disruption in rhythmic regulation. The author presents a treatment approach that emphasizes training the regulation of emotional arousal and discusses the impact of this approach on identity in this population. The major affect of concern is fear, and the primary goal of neurofeedback is seen as the reduction of fear and reactivity. The article attempts to elucidate the clinical challenges confronted when this is accomplished.
Neal E. Miller and His Research1
Authors: Coons Edgar E. , Leibowitz Sarah F. 
Published: December 2010

Abstract
Neal Miller's research contributions mainly concerned reward and learning mechanisms: (a) underlying thought processes and behaviors relevant to problem solving in psychotherapy and everyday life, (b) as mediated by the nervous system, and (c) involved in learning control over voluntary (conscious) skeletal muscle and autonomic (normally unconscious) internal-organ response systems for minimizing stress, treating disease, and promoting health. His career shows psychology's evolution from a theory-driven but data-impoverished discipline in the 1930s to one integrating vast bodies of clinical, social, and physiological knowledge.
What Psychology as a Science Owes Neal Miller: The Example of His Biofeedback Research
Authors: Taub Edward 
Published: December 2010

Abstract
Neal Miller did more to make psychology a science than any other investigator. His importance does not lie with any specific discoveries that he made, but rather with his way of doing scientific research, which involved pursuing a line of logic systematically through sequences of experiments, and paying attention to several alternate hypotheses that could answer each of the experimental questions addressed. His approach was a model of what has been called “Strong Inference” and that is characteristically used in the hard sciences. His biofeedback research is used as a case history of his method of approach.
Testimonial for and Reminiscences about Neal Miller
Authors: Bower Gordon H. 
Published: December 2010

Abstract
The author served as a research assistant with Neal Miller at Yale from 1955 to 1959. He narrates Miller's research activities on social learning and imitation, on personality and psychotherapy, and on brain structures mediating biological drives and rewards. He describes Miller's classroom teaching and relationships with graduate students. He pays tribute to Miller's encouragement for Bower's own research, and the life lessons and scientific lessons he provided for many of his students and young researchers.
Neal Miller and the Integration of Psychoanalysis and Behavior Therapy
Authors: Wachtel Paul L. 
Published: December 2010

Abstract
Neal Miller's pioneering insights into the possibilities of synthesis between psychoanalytic and learning theory formulations of phenomena of anxiety, defense, psychopathology, and personality dynamics provided a key foundation for later efforts to integrate psychodynamic and cognitive-behavioral approaches to therapy. This paper highlights Miller's influence and the continuing legacy of his integrative mindset in the contemporary psychotherapy integration movement.
Coagulation and inflammation
Authors: Lipinski S. , Bremer L. , Lammers T. , Thieme F. , Schreiber S. , Rosenstiel P. 
Published: December 2010

SummaryOverwhelming evidence has linked inflammatory disorders to a hypercoagulable state. In fact, thromboembolic complications are among the leading causes of disability and death in many acute and chronic inflammatory diseases. Despite this clinical knowledge, coagulation and immunity were long regarded as separate entities. Recent studies have unveiled molecular underpinnings of the intimate interconnection between both systems. The studies have clearly shown that distinct pro-inflammatory stimuli also activate the clotting cascade and that coagulation in turn modulates inflammatory signaling pathways.In this review, we use evidence from sepsis and inflammatory bowel diseases as a paradigm for acute and chronic inflammatory states in general and rise hypotheses how a systematic molecular understanding of the “inflammation-coagulation” crosstalk may result in novel diagnostic and therapeutic strategies that target the inflammation-induced hypercoagulable state.
Synthesis of Peptidomimetic Conjugates of Cyclic Nucleoside Phosphonates
Authors: Serpi Michaela , Krylov Ivan S. , Zakharova Valeria M. , McKenna Charles E. 
Published: December 2010

AbstractCyclic nucleoside phosphonates connected through a P‐O‐C linkage to a promoiety represent a class of prodrugs designed to overcome the low oral bioavailability of parent antiviral acyclic nucleoside phosphonates. In our prodrug approach, a nontoxic promoiety, such as an amino acid or dipeptide, is conjugated to the cyclic form of the parent drug by esterification of the phosphonic acid moiety with an alcoholic amino acid side chain (Ser, Tyr, and Thr) or a glycol linker. For the biological evaluation and investigation of the pharmacokinetic profiles of these modified nucleoside phosphonates, a reliable synthetic procedure that allows preparation of sufficient amount of potential prodrugs is needed. This unit provides a procedure for synthesizing peptidomimetic conjugates of two broad‐spectrum antiviral acyclic nucleoside phosphonates: (S)‐HPMPC and (S)‐HPMPA. Two alternate strategies allowing synthesizing selected amino acid, dipeptide, or ethylene glycol‐linked amino acid prodrugs of (S)‐HPMPC and (S)‐HPMPA in solution and using a solid‐phase approach are presented. Curr. Protoc. Nucleic Acid Chem. 43:15.4.1‐15.4.13. © 2010 by John Wiley & Sons, Inc.
Purification of Ribosomes from Human Cell Lines
Authors: Belin Stéphane , Hacot Sabine , Daudignon Lionel , Therizols Gabriel , Pourpe Stéphane , Mertani Hichem C. , Rosa‐Calatrava Manuel , Diaz Jean‐Jacques 
Published: December 2010

AbstractHighly conserved during evolution, the ribosome is the central effector of protein synthesis. In mammalian cells, the ribosome is a macromolecular complex composed of four different ribosomal RNAs (rRNA) and about 80 ribosomal proteins. Requiring more than 200 factors, ribosome biogenesis is a highly complex process that takes place mainly within the nucleoli of eukaryotic cells. Crystallographic data suggest that the ribosome is a ribozyme, in which the rRNA catalyses the peptide bond formation and ensures quality control of the translation. Ribosomal proteins are involved in this molecular mechanism; nonetheless, their role is still not fully characterized. Recent studies suggest that ribosomes themselves and/or the mechanisms underlying their synthesis, processing, and assembly play a key role in the establishment and progression of several human pathologies. The protocol described here is simple, efficient, and robust, and allows one to purify high‐quality ribosomes from human cultured cell lines. Ribosomes purified with this protocol are adequate for most of the subsequent analyses of their RNA and protein content. Curr. Protoc. Cell Biol. 49:3.40.1‐3.40.11. © 2010 by John Wiley & Sons, Inc.
Gene Down‐Regulation with Short Hairpin RNAs and Validation of Specificity by Inducible Rescue in Mammalian Cells
Authors: Ma Hoi Tang , Poon Randy Y.C. 
Published: December 2010

AbstractThe principal problem with RNA interference (RNAi) experiments is off‐target effects. The most vigorous demonstration of the specificity is the rescue of the RNAi effects with an RNAi‐resistant target gene. By combining the expression of short hairpin RNA (shRNA) and rescue cDNA in the same vector, both the validation of shRNA specificity and the generation of shRNA‐expressing cell lines can easily be accomplished. If the compensatory cDNA is under the control of an inducible promoter, stable shRNA‐expressing cells can be generated before the knockdown phenotypes are studied, by conditionally turning off the rescue protein. The use of model systems is detailed in these protocols. Curr. Protoc. Cell Biol. 49:27.2.1‐27.2.12. © 2010 by John Wiley & Sons, Inc.
Mechanically Durable Superhydrophobic Surfaces
Authors: Verho Tuukka , Bower Chris , Andrew Piers , Franssila Sami , Ikkala Olli , Ras Robin H. A. 
Published: December 2010

AbstractDevelopment of durable non‐wetting surfaces is hindered by the fragility of the microscopic roughness features that are necessary for superhydrophobicity. Mechanical wear on superhydrophobic surfaces usually shows as increased sticking of water, leading to loss of non‐wettability. Increased wear resistance has been demonstrated by exploiting hierarchical roughness where nanoscale roughness is protected to some degree by large scale features, and avoiding the use of hydrophilic bulk materials is shown to help prevent the formation of hydrophilic defects as a result of wear. Additionally, self‐healing hydrophobic layers and roughness patterns have been suggested and demonstrated. Nevertheless, mechanical contact not only causes damage to roughness patterns but also surface contamination, which shortens the lifetime of superhydrophobic surfaces in spite of the self‐cleaning effect. The use of photocatalytic effect and reduced electric resistance have been suggested to prevent the accumulation of surface contaminants. Resistance to organic contaminants is more challenging, however, oleophobic surface patterns which are non‐wetting to organic liquids have been demonstrated. While the fragility of superhydrophobic surfaces currently limits their applicability, development of mechanically durable surfaces will enable a wide range of new applications in the future.
The phenotype caused by PYCR1 mutations corresponds to geroderma osteodysplasticum rather than autosomal recessive cutis laxa type 2
Authors: Yıldırım Yeşerin , Tolun Aslıhan , Tüysüz Beyhan 
Published: December 2010

AbstractGeroderma osteodysplasticum is a rare autosomal recessive disorder characterized by wrinkled skin on the dorsum of the hands and feet, osteopenia, prognathism, and an elongated and lax face. The mutated gene was identified as GORAB (SCYL1BP1). As well, the PYCR1 gene also was shown to be mutated in a similar disease, designated cutis laxa, autosomal recessive, type IIB (ARCL2B) or cutis laxa with progeroid features. We describe here the clinical findings in four affected individuals in a family with geroderma osteodysplasticum with mental retardation and a homozygous mutation in PYCR1. Although the disease resulting from recessive mutations in that gene has been recently designated ARCL2B, some clinical features, such as prognathism, elongated and lax face, osteopenia and limitation of skin wrinkling to the dorsum of hands and feet, in the patients reported here as well as in others reported with PYCR1 mutations, are generally more common in geroderma osteodysplasticum resulting from recessive GORAB mutations. While the patients with GORAB mutations have severe osteopenia, the patients with PYCR1 mutations have severe mental retardation. In conclusion, the phenotype caused by PYCR1 mutations corresponds to geroderma osteodysplasticum rather than ARCL2B. © 2010 Wiley‐Liss, Inc.