bluuebunny/crossref_metadata_2025_split huggingface dataset:
The recognition and description of knapped lithic artifacts in thin section
Authors: Angelucci Diego E. 
Published: February 2010

AbstractStone tools occur quite frequently in sediment and soil thin sections, yet their micromorphological characteristics have not been explicitly defined in the literature. The aim of this paper is to define the criteria for the identification and description of knapped lithic artifacts composed of flint and quartzite by examining and comparing thin sections from prehistoric sites and petrographic thin sections obtained from lithic artifacts. The main characteristics that allow the micromorphologist to identify a knapped lithic artifact, besides its composition, grain size, and alteration degree, are: the tabular or platy shape; the angularity; the smooth surface; the prominent and regular boundary. Some examples taken from prehistoric sites in southern Europe show the reliability of these criteria for the recognition of stone tools in thin sections. © 2010 Wiley Periodicals, Inc.
Characterization and provenance of the slabs of the Puigseslloses Megalith, Barcelona, Spain
Authors: Vicens Enric , Arribas M. Eugenia , Clop Xavier , Estrada M. Rita , Maestro Eudald , Oms Oriol , Serrat David , Molist Miquel 
Published: February 2010

AbstractThe Puigseslloses megalith tomb (Barcelona, Spain) is located on the summit of a hill in the Vic Plain where the sedimentary rocks that were used in its construction do not crop out. A sedimentological and petrological characterization of the monument's slabs and a multidisciplinary analysis of the outcropping materials in nearby areas has allowed the identification of three possible source areas associated with the Paleogene Banyoles Marls Formation and the Folgueroles Sandstone Formation and allows us to propose possible routes by which the slabs were transported from the catchment site to the place where the monument was built. In addition, the lithology and position of different slabs within the megalith denote the intention to separate the chamber from the corridor by using different types of slab. The position of the monument also reveals that tomb location was more of a priority than proximity to the slab sources. © 2010 Wiley Periodicals, Inc.
The geoarchaeological and paleoenvironmental context of Paleoindian sites in western Middle Park, Colorado, USA
Authors: Mayer James H. , Reider Richard G. , Kornfeld Marcel 
Published: February 2010

AbstractGeoarchaeological investigations in western Middle Park provide important information for understanding the soil‐stratigraphic context of Paleoindian components, as well as the latest Quaternary environmental change and landscape evolution in a Southern Rocky Mountain intermontane basin. Paleoindian components are associated with the oldest two of four latest Quaternary stratigraphic units (1–4) recognized in co‐alluvial mantles (combined slopewash and colluvium) in uplands and in alluvial valley fills. Limited data suggest accumulation of unit 1 as early as ∼12,500 14C yr B.P. in alluvial valleys and by at least ∼11,000 14C yr B.P. in uplands was followed by brief stability and soil formation. A relatively widespread disconformity marks earliest Holocene erosion and substantial removal of latest Pleistocene deposits in upland and alluvial settings followed by unit 2 deposition ∼10,000–9000 14C yr B.P., perhaps signaling the abrupt onset of an intensified summer monsoon. In situ Paleoindian components in uplands are found in a moderately developed buried soil (the Kremmling soil) formed in units 1 and 2 in thin (≤1m) hillslope co‐alluvial mantles. The Kremmling soil reflects geomorphic stability in upland and alluvial settings ∼9000–4500 14C yr BP, and represents a buried landscape with the potential to contain additional Paleoindian components, although elsewhere in western Middle Park Early Archaic components are documented in morphologically similar soils. Kremmling soil morphology, the relative abundance of charcoal in unit 2 relative to younger units, and charcoal morphology indicate the expansion of forest cover, including Pinus, and grass cover during the early and middle Holocene, suggesting conditions moister than present. © 2010 Wiley Periodicals, Inc.
Morphological and geochemical analysis of the Laguna Blanca/Zapaleri obsidian source in the Atacama Puna
Authors: Seelenfreund Andrea , Pino Mario , Glascock Michael D. , Sinclaire Carole , Miranda Pedro , Pasten Denisse , Cancino Simón , Dinator María Inés , Morales José Roberto 
Published: February 2010

AbstractThis paper describes a large obsidian deposit located along the southern banks of Laguna Blanca, on the eastern slope of the Jarellón volcanic caldera near the Chilean–Bolivian border. The obsidian at this site occurs in flows or sheets of deflated black or reddish to brown pebbles, redeposited on the shores of a lake. Blocks of obsidian are only found around the caldera rim. Here we analyze the shape of the obsidian pebbles and their geochemistry, comparing them with previously published data. The results indicate that the geochemical composition of the samples strongly matches previous analyses of obsidian from cultural contexts. This obsidian source was one of the most important sites of obsidian procurement since at least the Formative Period in the Atacama Puna region. © 2010 Wiley Periodicals, Inc.
New Diarylheptanoids and Kavalactone from Alpinia katsumadaiHayata
Authors: Li Yuan‐Yuan , Chou Gui‐Xin , Wang Zheng‐Tao 
Published: February 2010

AbstractTwo new diarylheptanoids, katsumains A (1) and B (2), and one new kavalactone, katsumadain (3), together with the three known compounds (4E,6E)‐1,7‐diphenylhepta‐4,6‐dien‐3‐one (4), (5R,6E)‐1,7‐diphenyl‐5‐hydroxyhept‐6‐en‐3‐one (5), and cardamonin (6), were isolated from the seeds of Alpinia katsumadai Hayata. Their structures were elucidated mainly by spectroscopic methods (1D‐ and 2D‐NMR) and by mass spectrometry (HR‐ESI‐MS). Besides, the erroneous nomenclatures for (+)‐linderatin and (+)‐neolinderatin as given in [10] [11] were corrected to be 2′,4′,6′‐trihydroxy‐3′‐[(3R,4R)‐4‐isopropyl‐1‐methylcyclohex‐1‐en‐3‐yl]dihydrochalcone for (+)‐linderatin and 2′,4′,6′‐trihydroxy‐3′,5′‐bis[(3R,4R)‐4‐isopropyl‐1‐methylcyclohex‐1‐en‐3‐yl]dihydrochalcone for (+)‐neolinderatin, respectively.
New C27 Steroidal Bisdesmosides from the Fresh Stems of Dracaena cambodiana
Authors: Xu Min , Yang Chong‐Ren , Zhang Ying‐Jun 
Published: February 2010

AbstractTwo new steroidal bisdesmosides, cambodracanosides A and B (1 and 2, resp.), were isolated from the fresh stems of Dracaena cambodiana, together with seven known glycosides. The structures of the new saponins were elucidated on the basis of detailed spectroscopic analyses, including 1D‐ and 2D‐NMR techniques, and acidic hydrolysis.
Spirostanol Saponins from the Fibrous Roots of Ophiopogon japonicus (Thunb.) Ker‐Gawl
Authors: Duan Chang‐Ling , Li Yu‐Juan , Li Peng , Jiang Yong , Liu Jian‐Xun , Tu Peng‐Fei 
Published: February 2010

AbstractThree new steroidal saponins, (25R)‐ruscogenin‐3‐yl α‐L‐rhamnopyranosyl‐(1→2)‐[β‐D‐xylopyranosyl‐(1→4)]‐β‐D‐glucopyranoside (1), diosgenin‐3‐yl 2‐O‐acetyl‐α‐L‐rhamnopyranosyl‐(1→2)‐[β‐D‐xylopyranosyl‐(1→4)]‐β‐D‐glucopyranoside (2), and pennogenin‐3‐yl 2‐O‐acetyl‐α‐L‐rhamnopyranosyl‐(1→2)‐[β‐D‐xylopyranosyl‐(1→4)]‐β‐D‐glucopyranoside (3) were isolated from the fibrous roots of Ophiopogon japonicus (Thunb.) Ker‐Gawl. Their structures were determined by spectroscopic methods including IR, HR‐ESI‐MS, and 1D‐ and 2D‐NMR. All of these three steroidal saponins exhibited weak cytotoxicities against Hela and Hep2 cell lines.
Four New 1,4‐Benzoquinone Derivatives and One New Coumarin Isolated from Ardisia gigantifolia
Authors: Liu Hongwei , Zhao Yisong , Yang Ruiyun , Zheng Meiqing , Wang Manyuan , Zhang Xue , Qiu Feng , Wang Hengshan , Zhao Feng 
Published: February 2010

AbstractFour new 1,4‐benzoquinone derivatives, belamcandaquinones J (1), K (2), L (3), and M (4), and one new coumarin, 5, were isolated from the rhizome of Ardisia gigantifolia. Their structures were established by means of spectroscopic methods, and their cytotoxicity was tested in vitro against the cell lines PC‐3, EMT6, A549, Hela, RM‐1, and SGC7901. In comparison with cisplatin, compound 5 showed strong cytotoxicity with an IC50 value of <30 μM against the cell lines PC‐3 and A549. Compounds 1–4 showed no cytotoxicity against all cell lines.
Peroxide/Potassium Iodide Redox Systems for in situ Oxyiodination of Organic Compounds under Liquid‐Phase and Solvent‐Free Conditions
Authors: Venkateshwarlu Gattu , Premalatha Akarapu , Chakradhar Anuganti , Rajanna Kamatala Chinna , Prakash Pondichery Kuppuswamy Sai 
Published: February 2010

AbstractIodination of certain aromatic amines and phenols are triggered by the oxidation of KI by peroxy compounds such as tert‐butyl hydroperoxide (tBuOOH) under liquid‐phase and solvent‐free conditions by grinding the reactants in a mortar with a pestle. The reactions afforded corresponding iodo derivatives in good yield with high regioselectivity (Table 1).
New Triterpenoid Saponins from the Roots of Gypsophila paniculata L.
Authors: Yao Shun , Ma Li , Luo Jian‐Guang , Wang Jun‐Song , Kong Ling‐Yi 
Published: February 2010

AbstractThe seven new triterpenoid saponins 1–7 were isolated from the roots of Gypsophila paniculata L. Their structures were established by 1D‐ and 2D‐NMR techniques, HR‐MS, and acid hydrolysis. The isolated compounds include 3,28‐O‐bidesmosides with or without a 4‐methoxycinnamoyl group (see 1 vs. 2 and 3), and 3‐O‐monoglucosides 4–7. All isolated saponins 1–7 and their aglycones were evaluated for their α‐glucosidase inhibition activity. Compound 1 showed inhibitory activity against yeast α‐glucosidase with an IC50 value of 100.9±3.3 μM, whereas compounds 2–7 were inactive.
Two New 7‐Dehydrobrefeldin A Acids from Cylindrocarpon obtusisporum, an Endophytic Fungus of Trewia nudiflora
Authors: Yu Bu‐Zhu , Zhu Na , Du Zhi‐Zhi 
Published: February 2010

AbstractTwo new 7‐dehydrobrefeldin A acids, (2E,4R*)‐4‐hydroxy‐4‐{(1R*,2S*)‐4‐oxo‐2‐[(1E)‐6‐oxohept‐1‐en‐1‐yl]cyclopentyl}but‐2‐enoic acid (3) and (2E,4R*)‐4‐hydroxy‐4‐{(1R*,2S*)‐2‐[(1E,6S*)‐6‐hydroxyhept‐1‐en‐1‐yl]‐4‐oxocyclopentyl}but‐2‐enoic acid (4), were isolated from the endophytic fungal strain Cylindrocarpon obtusisporum (Cooke & Harkness) Wollenw. of Trewia nudiflora, together with two known compounds, 7‐dehydrobrefeldin A (2) and brefeldin A (1). Their structures were determined on the basis of extensive 1D‐ and 2D‐NMR‐spectral analysis.
Tanacetamide D: A New Ceramide from Tanacetum artemisioides
Authors: Hussain Javid , Munir Meamoona , Hassan Zahid , Bano Naseem , Arshad Saima , Ahmad Viqar Uddin 
Published: February 2010

AbstractOne new ceramide (=long‐chain base linked to a fatty acid via an amide bond), tanacetamide D (1), was isolated from Tanacetum artemisioides. Besides this, the two known constituents 5‐demethylnobiletin (2) and 5‐hydroxy‐3,6,7,8,3′,4′‐hexamethoxyflavone (3) were isolated for the first time from this species. The structure elucidation of the isolated compounds were based primarily on 2D‐NMR techniques including correlation spectroscopy (COSY), heteronuclear multiple‐quantum coherence (HMQC), heteronuclear multiple‐bond correlation (HMBC), and nuclear Overhauser effect spectroscopy (NOESY) experiments.
Microwave‐Induced Stereocontrol of β‐Lactam Formation with an N‐Benzylidene‐9,10‐dihydrophenanthren‐3‐amine via Staudinger Cycloaddition
Authors: Bandyopadhyay Debasish , Banik Bimal K. 
Published: February 2010

AbstractThe synthesis of 3‐substituted 4‐phenyl‐1‐(9,10‐dihydrophenanthren‐3‐yl)azetidin‐2‐ones was achieved following Staudinger cycloaddition under microwave‐induced conditions. The stereoselectivity of β‐lactam formation depended on the power level of the microwave irradiation used in the experiments.
Controlled Ethylene Polymerization Catalyzed by Cp$\rm{{_{2}^{\ast}}}$ZrBu2/[Ph3C] [B(C6F5)4]/iBu4Al2O above Room Temperature
Authors: Mathis Déborah , Rouholahnejad Fereshteh , Chen Peter 
Published: February 2010

AbstractThe ternary system composed of Cp$\rm{{_{2}^{\ast}}}$ZrBu2 (Cp*=Me5Cp), [CPh3][B(C6F5)4], and tetraisobutyldialuminoxane (TIBAO) catalyzed the polymerization of ethylene in a controlled fashion at temperatures up to 60 °C. The consumption of ethylene remained constant during the polymerization process, the molecular weight of the polyethylene increased linearly with time, and polydispersity indexes down to 1.3 were obtained. Characterization of the polyethylene by 13C‐NMR and FT‐IR spectroscopy did not indicate any branching or CC linkages, even for polymer produced at 40 °C or above. The linear and saturated polymer structure is due to the absence of β‐hydride transfer, β‐hydride elimination and chain walking during the polymerization. The absence of termination reactions is consistent with the system's demonstrated controlled polymerization.
Drug–Membrane Interaction on Immobilized Liposome Chromatography Compared to Immobilized Artificial Membrane (IAM), Liposome/Water, and Octan‐1‐ol/Water Systems
Authors: Liu Xiangli , Fan Ping , Chen Ming , Hefesha Hossam , Scriba Gerhard K. E. , Gabel Detlef , Fahr Alfred 
Published: February 2010

AbstractThe objective of this study was to investigate drug–membrane interaction by immobilized liposome chromatography (ILC; expressed as lipophilicity index log Ks) and the comparison with lipophilicity indices obtained by liposome/H2O, octan‐1‐ol/H2O, and immobilized artificial membrane (IAM) systems. A set of structurally diverse monofunctional compounds and drugs (nonsteroidal anti‐inflammatory drugs and β‐blockers) were selected in this study. This set of solutes consists of basic or acidic functionalities which are positively or negatively charged at physiological pH 7.4. No correlation was found between log Ks from ILC and lipophilicity indices from any of the other membrane model systems for the whole set of compounds. For structurally related compounds, significant correlations could be established between log Ks from ILC and lipophilicity indices from IAM chromatography and octan‐1‐ol/H2O. However, ILC and liposome/H2O systems only yield parallel partitioning information for structurally related large molecules. For hydrophilic compounds, the balance between electrostatic and hydrophobic interactions dominating drug partitioning is different in these two systems.
Synthesis and Characterization of a Novel Diels–Alder Adduct of Codeine
Authors: Cunningham Christopher W. , Hom Kellie , Acharya Chayan , Wilks Angela , MacKerell Alexander D. , Coop Andrew 
Published: February 2010

AbstractThe Diels–Alder reaction was applied to 4,5‐epoxymorphinan opioids to generate a novel aromatic cycloadduct at C(7)C(8): Thermolytic cleavage of sultine 8 produced the reactive diene o‐quinodimethane 7 which condensed favorably with codeine (11), but not with codeinone (9) or 14‐hydroxycodeinone (10), producing the desired tetrahydronaphtho adduct 12 with (7R,8R) geometry (Scheme). The configuration of the cycloadduct was determined by 1D‐ and 2D‐NMR experiments. The unanticipated reactivity of these codeine derivatives was investigated by quantum‐mechanical calculations, and it was determined that steric effects of the 6‐keto and 14‐hydroxy group likely precluded condensation by raising the molecular energy of their respective transition states.
Synthesis of Carbocyclic Pyrimidine Nucleosides Using the Mitsunobu Reaction: O2‐ vs. N1‐Alkylation
Authors: Quezada Elías , Viña Dolores , Delogu Giovanna , Borges Fernanda , Santana Lourdes , Uriarte Eugenio 
Published: February 2010

AbstractThe Mitsunobu reaction is an important tool in carbocyclic nucleoside chemistry for the direct coupling of alcohols with heterocyclic bases under mild conditions. Chemical evidences for an unusual competitive O2‐ vs. N1‐alkylation of 3‐substituted pyrimidines is presented.
Nitrogen‐Rich Compounds of the Lanthanoids: Highlights and Summary
Authors: Steinhauser Georg , Giester Gerald , Leopold Nicolae , Wagner Christoph , Villa Mario , Musilek Andreas 
Published: February 2010

AbstractIn this third part of our research on the 5,5′‐azobis[1H‐tetrazol‐1‐ides] (ZT) of the lanthanoids, we present two compounds with La2(ZT)3 moieties with very different coordination modes between the cations and the anions. One La2(ZT)3‐containing compound is interesting, because it contains trimeric La3(ZT)3III cations, which are arranged in a windmill‐like structure. Moreover, the first double salt of a ZT compound, namely the carbonate compound La2(ZT)2(CO3)⋅12 H2O, is presented and discussed. Another highlight of nitrogen chemistry is the first molecular structure of a 5‐azido‐2H‐tetrazole (CHN7) molecule, in the form of the spectacular compound Dy2(ZT)3⋅4 CHN7⋅24 H2O. This is the first known complete molecular structure of an azidotetrazole molecule (the organic molecule with the highest nitrogen‐content: 88.3% N). All compounds have been characterized completely including elemental analyses, vibrational (IR and Raman) spectroscopy, and X‐ray crystal‐structure determination. We summarize our ‘nitrogen‐rich compounds of the lanthanoids’ project and extensively discuss selected literature on this topic and compare previously published results with ours.
Endovenous laser therapy – application studies and latest investigations
Authors: Sroka Ronald , Weick Kathrin , Sadeghi‐Azandaryani Mojtaba , Steckmeier Bernd , Schmedt Claus‐Georg 
Published: February 2010

AbstractEndovenous laser therapy (ELT) was introduced in clinical practice as a therapy for incompetent veins about ten years ago. One characteristic of ELT is the broad spectrum of different treatment protocols by means of a variety of laser systems as well as manifold application forms and dosimetry concepts are under investigations. Clinical results with effective, relatively pain‐free occlusion of incompetent varicosis veins have been observed, as well as undesired side effects such as ecchymosis, phlebitis and recanalization. In recent years systematic experimental investigations and the analysis of clinical results have increased the understanding of the interrelation between the clinical and physical aspects, followed to a continuous optimization of ELT. The use of IR wavelengths and radial irradiation concepts, together with continuous moving of the optical fiber seem to reduce possible side effects. This way ELT treatment becomes a more standardized effective method for the treatment of varicose veins. In future controlled randomized studies are required to compare optimized ELT treatment with other endoluminal modalities as well as conventional surgery. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Brillouin gain spectrum tailoring technique by using fiber concatenation and strain for fiber devices
Authors: Galindez C. A. , Ullan A. , Madruga F. J. , López‐Higuera J. M. 
Published: February 2010

AbstractA technique to develop all‐fiber devices based on the customization of Brillouin gain spectrum is proposed in this article. It is based on the proper concatenation and elongation of optical fibers. To check experimentally the proposed technique, an optical device with a “like W” stimulated Brillouin scattering shape was implemented. Our experiment shows a 3‐dB bandwidth of 219 MHz with two reject bands placed at 10.7855 and 10.876 GHz, respectively, from the pump wavelength. Optical devices such as Brillouin amplifiers or Brillouin filters can be developed using the proposed technique. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52:787–790, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25033
Dark soliton generation using dual Brillouin fiber laser in a fiber optic ring resonator
Authors: Hanim S. F. , Ali J. , Yupapin P. P. 
Published: February 2010

AbstractStable dark soliton pulses have been successfully generated in an erbium doped dispersion compensated fiber (DCF) using an enhanced dual Brillouin fiber laser (DBFL) scheme.Multidark soliton pulses generation in an S‐band erbium doped depressed cladding fiber (DC‐EDF) using a multiwavelength Brillouin fiber laser (MW‐BFL). Configuration has also been successfully demonstrated. The hybrid amplification from the 300 mW power of Raman pump (RP), 7.7 km long DCF, and 30 m DC‐EDF that is being pumped bidirectionally results in a stable multiwavelength Brillouin peaks in the S‐band region. Results obtained shows that the insertion of linear gain medium with bidirectional pumping of the DC‐EDF into the cavity gives significant amplification and promotes the formation of stokes peaks in the S‐band region. The number of Brillouin peaks generated is closely dependent on the DBFL and MW‐BFL configuration, the Brillouin pump (BP) signal wavelength, the BP coupling ratio, and the RP power. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52:881–883, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25036
A noncoherent IR‐UWB CMOS receiver for 3–5 GHz application
Authors: Ha Mincheol , Park Youngjin , Lee Jae‐Seung , Eo Yunseong 
Published: February 2010

AbstractA fully integrated noncoherent IR‐UWB CMOS receiver is implemented using 0.18 μm CMOS technology.To remove the bulky and lossy external balun, the receiver contains single to differential circuit embedded in low‐noise amplifier (LNA) stages. The LNA stage also includes a tunable LC load for band selection. The measured results show that the sensitivity is −78.9 dBm at 1 Mbps in condition of BER of 10–3. The chip size is 2.3 mm × 1.3 mm including pads. The consumed current is 20 mA at 1.8 V supply. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52:914–917, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25039
Fast and accurate calculation of transmission coefficients for an EBG microstrip structure
Authors: Ying Huang Shao , Hui Lee Yee 
Published: February 2010

AbstractIn this article, an approach is proposed to provide an accurate and fast calculation on the transmission coefficients of an electromagnetic band‐gap (EBG) structures where patches are periodically inserted into the microstrip line (capacitive loaded EBG microstrip structure). The stopband performance, such as the center frequency, bandwidth, and attenuation, of these EBG structures can be predicted at a high degree of accuracy through the calculation of the transmission coefficient. The dispersion relation of electromagnetic waves in the structure is derived, plotted, and analyzed. The grating nature of the structure is demonstrated. This approach can be applied to periodic microstrip structures of a similar nature to simplify the analysis and design procedures. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52:793–797, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25046
UWB portable printed monopole array design for MIMO communications
Authors: Valderas Daniel , Crespo Pedro , Ling Cong 
Published: February 2010

AbstractAntenna arrays that incorporate MIMO technology for indoor–outdoor network interconnection on the same terminal, i.e., for DCS 1800, PCS 1900, WCDMA, 3G, 802.11a/b/g, Bluetooth®, ZigBee®, WiMAX™, and UWB standards, are proposed. Staircase profile printed circuit antennas, monopoles (PCM), and slots (PCS) with VSWR < 2 bandwidth mainly from 1.12 to 10.1 GHz are previously designed, simulated, constructed, and measured as antenna elements for those arrays. For comparison, prototypes for two‐element PCM and PCS MIMO arrays have been constructed and measured. The choice should be made according to the directivity required by the final application and portable device size. For the worst signal interference case, the operational bandwidth ranges from 1.5 to 9.9 GHz and from 1.7 to 11.4 GHz for the PCM and the PCS MIMO arrays, respectively. VSWR is basically below two, average capacity loss 0.32 bps/Hz with respect to the ideal uncorrelated (2,2) case and envelope correlation lower than 20 dB. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52:889–895, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25047