bluuebunny/crossref_metadata_2025_split huggingface dataset:
MD-DATA: the legacy of the ABC Consortium
Authors: Hospital Adam , Orozco Modesto 
Published: May 2024

AbstractThe ABC Consortium has been generating nucleic-acids MD trajectories for more than 20 years. This brief comment highlights the importance of this data for the field, which triggered a number of critical studies, including force-field parameterization and development of new coarse-grained and mesoscopic models. With the world entering into a new data-driven era led by artificial intelligence, where data is becoming more essential than ever, the ABC initiative is leading the way for nucleic acid flexibility.
Crosstalk between cancer cells and macrophages promotes OSCC cell migration and invasion through a CXCL1/EGF positive feedback loop
Authors: Huang Wei , Jiang Mingjing , Lin Ying , Qi Ying , Li Bo 
Published: May 2024

Abstract
Background
C-X-C motif chemokine ligand 1 (CXCL1) and epithelial growth factor (EGF) are highly secreted by oral squamous cell carcinoma (OSCC) cells and tumor-associated macrophages, respectively. Recent studies have shown that there is intricate "cross-talk" between OSCC cells and macrophages. However, the underlying mechanisms are still poorly elucidated.

Methods
The expression of CXCL1 was detected by immunohistochemistry in OSCC clinical samples. CXCL1 levels were evaluated by RT‒PCR and ELISA in an OSCC cell line and a normal epithelial cell line. The expression of EGF was determined by RT‒PCR and ELISA. The effect of EGF on the proliferation of OSCC cells was evaluated by CCK-8 and colony formation assays. The effect of EGF on the migration and invasion ability and epithelial-mesenchymal transition (EMT) of OSCC cells was determined by wound healing, Transwell, RT‒PCR, Western blot and immunofluorescence assays. The polarization of macrophages was evaluated by RT‒PCR and flow cytometry. Western blotting was used to study the molecular mechanism in OSCC.

Results
The expression of C-X-C motif chemokine ligand 1 (CXCL1) was higher in the OSCC cell line (Cal27) than in immortalized human keratinocytes (Hacat cells). CXCL1 derived from Cal27 cells upregulates the expression of epithelial growth factor (EGF) in macrophages. Paracrine stimulation mediated by EGF further facilitates the epithelial-mesenchymal transition (EMT) of Cal27 cells and initiates the upregulation of CXCL1 in a positive feedback-manner. Mechanistically, EGF signaling-induced OSCC cell invasion and migration can be ascribed to the activation of NF-κB signaling mediated by the epithelial growth factor receptor (EGFR), as determined by western blotting.

Conclusions
OSCC cell-derived CXCL1 can stimulate the M2 polarization of macrophages and the secretion of EGF. Moreover, EGF significantly activates NF-κB signaling and promotes the migration and invasion of OSCC cells in a paracrine manner. A positive feedback loop between OSCC cells and macrophages was formed, contributing to the promotion of OSCC progression.
Characterization of HIV variants from paired Cerebrospinal fluid and Plasma samples in primary microglia and CD4+ T-cells
Authors: Gumbs Stephanie B. H. , Stam Arjen J. , Mudrikova Tania , Schipper Pauline J. , Hoepelman Andy I. M. , van Ham Petra M. , Borst Anne L. , Hofstra LMarije , Gharu Lavina , van Wyk Stephanie , Wilkinson Eduan , de Witte Lot D. , Wensing Annemarie M. J. , Nijhuis Monique 
Published: May 2024

AbstractDespite antiretroviral therapy (ART), HIV persistence in the central nervous system (CNS) continues to cause a range of cognitive impairments in people living with HIV (PLWH). Upon disease progression, transmigrating CCR5-using T-cell tropic viruses are hypothesized to evolve into macrophage-tropic viruses in the CNS that can efficiently infect low CD4-expressing cells, such as microglia. We examined HIV-1 RNA concentration, co-receptor usage, and CSF compartmentalization in paired CSF and blood samples from 19 adults not on treatment. Full-length envelope CSF- and plasma-derived reporter viruses were generated from 3 subjects and phenotypically characterized in human primary CD4+ T-cells and primary microglia. Median HIV RNA levels were higher in plasma than in CSF (5.01 vs. 4.12 log10 cp/mL; p = 0.004), and coreceptor usage was mostly concordant for CCR5 across the paired samples (n = 17). Genetically compartmentalized CSF viral populations were detected in 2 subjects, one with and one without neurological symptoms. All viral clones could replicate in T-cells (R5 T cell-tropic). In addition, 3 CSF and 1 plasma patient-derived viral clones also had the capacity to replicate in microglia/macrophages and, therefore have an intermediate macrophage tropic phenotype. Overall, with this study, we demonstrate that in a subset of PLWH, plasma-derived viruses undergo genetic and phenotypic evolution within the CNS, indicating viral infection and replication in CNS cells. It remains to be studied whether the intermediate macrophage-tropic phenotype observed in primary microglia represents a midpoint in the evolution towards a macrophage-tropic phenotype that can efficiently replicate in microglial cells and propagate viral infection in the CNS.
The Association between Circadian Syndrome and Frailty in US adults: a cross-sectional study of NHANES Data from 2007 to 2018
Authors: Sun Lirong , Huo XingWei , Jia Shanshan , Chen Xiaoping 
Published: May 2024

Abstract
Purpose
Frailty and Circadian Syndrome (CircS) are prevalent among the elderly, yet the link between them remains underexplored. This study aims to examine the association between CircS and frailty, particularly focusing on the impact of various CircS components on frailty.

Materials and methods
We conducted a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) spanning 2007 to 2018. The 49-item Frailty Index (FI) was employed to assess frailty. To understand the prevalence of CircS in relation to frailty, we applied three multivariate logistic regression models. Additionally, subgroup and interaction analyses were performed to investigate potential modifying factors.

Results
The study included 8,569 participants. In fully adjusted models, individuals with CircS showed a significantly higher risk of frailty compared to those without CircS (Odds Ratio [OR] = 2.18, 95% Confidence Interval [CI]: 1.91–2.49, p < 0.001). A trend of increasing frailty risk with greater CircS component was observed (trend test p < 0.001). Age (p = 0.01) and race (p = 0.02) interactions notably influenced this association, although the direction of effect was consistent across subgroups. Sensitivity analysis further confirmed the strength of this relationship.

Conclusion
This study identifies a strong positive correlation between CircS and frailty in the elderly. The risk of frailty escalates with an increasing number of CircS components. These findings highlight the intricate interplay between circadian syndrome and frailty in older adults, offering valuable insights for developing targeted prevention and intervention strategies.
Effect of social participation on the trajectories of activities of daily living disability among community-dwelling older adults: a 7-year community-based cohort
Authors: Wen Cai , Sun Shuangyuan , Huang Limei , Guo Yanfei , Shi Yan , Qi Shige , Ding Guomei , Wen Zhiqin , Wang Jiaqi , Ruan Ye , Zhao Qi 
Published: May 2024

Abstract
Introduction
Studies examining the effects of social participation on activities of daily living (ADL) disability are still scarce.

Aim
To assess the reciprocal relationship between ADL disability trajectories and social participation among older Chinese people aged ≥ 60 years.

Methods
This study included 2976 participants aged ≥ 60 years in six waves of a community-based survey from 2015 to 2022. Basic activities of daily living (BADL) and instrumental activities of daily living (IADL) were used to assess the ADL disability in each survey. Social participation was assessed by involvement in four social activities and an extensive social participation score. Group-based trajectory modeling was used to identify potential heterogeneity in longitudinal changes over 7 years and explore associations between baseline predictors of group membership and these trajectories.

Results
Two BADL disability trajectories were identified: stable (94.8%) and increase (5.2%). Additionally, three IADL disability trajectories were distinguished: stable (73.2%), moderate (20.2%), and increase (6.6%). After controlling for the potential covariates, each point increase in the extensive social participation score correlated with a 17% decrease in the odds of older individuals belonging to the increase BADL trajectory group (OR = 0.83, 95% CI = 0.68–1.00). For IADL, it decreased the odds of being assigned to the moderate trajectory group by 16% (OR = 0.84, 95% CI = 0.75–0.95) and to the increase trajectory group by 23% (OR = 0.77, 95% CI = 0.64–0.93).

Conclusions
Higher levels of social participation among older individuals were more likely to be classified as stable trajectories in both BADL and IADL. Increased participation in social activities by community-dwelling elderly adults may promote healthy aging.
Generative AI and Usage in Marketing Classroom
Authors: Ding Min , Dong Songting , Grewal Rajdeep 
Published: May 2024

Abstract
This article examines the role of Generative Artificial Intelligence (GenAI) in the context of marketing education, highlighting its substantial impact on the field. The study is based on an analysis of how GenAI, particularly through the use of Large Language Models (LLMs), functions. We detail the operational mechanisms of LLMs, their training methods, performance across various metrics, and the techniques for engaging with them via prompt engineering. Building on this foundation, we explore popular GenAI platforms and models that are relevant to marketing, focusing on their key features and capabilities. We then assess the practical applications of GenAI in marketing tasks and educational settings, considering its utility in tasks such as providing information, extracting data, generating content, conducting simulations, and performing data analysis. By examining these areas, this paper demonstrates the integral role of GenAI in reshaping both marketing strategies and teaching methodologies and argues for its adoption as a critical resource for forward-thinking marketers and educators.
Implementierung von Maßnahmen zur Optimierung psychischer Belastungen im Kontext Hochschule
Authors: Diebig Mathias , Heming Meike , Angerer Peter 
Published: May 2024

Zusammenfassung
Hintergrund
Aufgrund der aktuell sehr großen Anforderungen an wissenschaftliche Beschäftigte in deutschen Hochschulen steigt der Bedarf an Maßnahmen, die helfen, Arbeitsbedingungen in diesem Kontext zu analysieren, zu verändern und zu optimieren. Tatsächlich ist die Umsetzungsquote solcher Maßnahmen im Hochschulkontext aktuell sehr gering, und die Gründe für diese unzureichende Umsetzung sind nur teilweise aufgedeckt.

Ziel der Arbeit
Mittels Ergebnissen aus Interviews und Fallstudien soll ein Einblick in die Praxis geben werden. Es soll aufgezeigt werden, welche psychischen Belastungen im wissenschaftlichen Umfeld als kritisch bewertet werden und welche konkreten Vorgehensweisen zu deren Optimierung sich im Kontext Hochschule eignen.

Material und Methoden
In sieben qualitativen Interviews soll der Stellenwert von Gesundheit, typischen Stressoren bei der Arbeit, Herangehensweisen zur Förderung der Gesundheit der Beschäftigten sowie Wünschen und Erwartungen an Leitungsgremien von Hochschulen erörtert werden. In sechs Fallstudien wird der Fokus auf einzelne wissenschaftliche Einheiten gerichtet und beispielhaft die Durchführung von Vorgehensweisen zur Verbesserung der Arbeitsbedingungen erprobt. Interviews und Fallstudien wurden dokumentiert und qualitativ ausgewertet.

Ergebnisse
Die Ergebnisse zeigen, welche Herangehensweisen zur Gestaltung von Arbeitsbedingungen im Kontext Hochschule eingesetzt werden und mit welchen Herausforderungen und Problemen diese Ansätze verbunden sind. Es zeigt sich auch, dass trotz der hohen Bedeutung von gesundheitlichen Themen in den Einheiten der Bedarf an geeigneten Maßnahmen zur Verbesserung von Arbeitsbedingungen eher gering ist.

Diskussion
Der Beitrag gibt einen Einblick in die organisatorische Praxis. Es soll weitere Forschung angestoßen werden, die dazu beiträgt, dass Maßnahmen zur Optimierung psychischer Belastungen im Kontext Hochschule weiter etabliert werden.
Coupled connectivity in the global complex network: the case of United Kingdom (1880–1925)
Authors: Polo-Martín Bárbara , Ducruet César 
Published: May 2024

AbstractThe main objective of this research is to analyse the connectivity of cities in a coupled network composed of planar (railways) and non-planar (maritime) topologies. It examines the state of the network during the 1880–1925 period, namely in the context of the first globalization wave (1880–1914), when trade and urban development were closely tied to progress in communications systems and steam propulsion especially. Edges represent intercity physical infrastructure on land, and inter-port ship voyages at sea. We tested several hypotheses in terms of inter-network specialisation and urban hierarchies with an application in the United Kingdom. The main results reveal that the networks are highly interdependent, whereas combined centrality is closely associated with city size and urban growth. We discuss the key results in light of network science, spatial science, maritime history, and transport research.
Locating Australian school students in sites of curriculum making: a literature review
Authors: Cairns Rebecca 
Published: May 2024

AbstractYoung people and children are central to conceptualisations of curriculum as a social process, especially in school-based settings. However, students have tended to be on the periphery of education policy development more broadly and curriculum reform more specifically. As a more inclusive approach to engaging students in curriculum consultation processes is beginning to be taken in Australia, it is timely to gauge the extent to which students are being actively engaged as curriculum actors and research participants across the Australian curricular landscape. This article draws on Priestley et al.’s (2021) sites of curriculum making model to frame a systematised literature review of a decade of Australian academic and grey literature for the purpose of identifying the sites and activities in which students are active and/or the focus of research. The review suggests there is a small body of research on curriculum negotiation within school-based nano and micro sites of curriculum making. However, an absence of academic research related to meso and macro curriculum making means we have a limited understanding of the dynamics of the activities, interactions, contestations and power relations that constitute curriculum making in these spaces in relation to students. This article considers some of the reasons for and implications of these trends, including how existing curriculum and student voice scholarship might inform future research. It argues that a better understanding of the possibilities and challenges of student-centred curriculum making activities could assist in moving beyond superficial “consultation” methods, especially during periods of significant curriculum renewal.
Dibble’s Reduction Thesis: Implications for Global Lithic Analysis
Authors: Shott Michael J. 
Published: May 2024

Abstract
Harold Dibble demonstrated the systematic effects of reduction by retouch upon the size and shape of Middle Paleolithic tools. The result was the reduction thesis, with its far-reaching implications for the understanding of Middle Paleolithic assemblage variation that even now are incompletely assimilated. But Dibble’s influence extended beyond the European Paleolithic. Others identified additional reduction methods and measures that complement Dibble’s reduction thesis, and applied analytical concepts and methods consistent with it to industries and assemblages around the world. These developments facilitated comprehensive reduction analysis of archaeological tools and assemblages and their comparison in the abstract despite the great diversity of their time–space contexts. Dibble argued that many assemblages are time-averaged accumulations. In cases from New Zealand to North America, methods he pioneered and that others extended reveal the complex processes by which behavior, tool use, curation, and time interacted to yield those accumulations. We are coming to understand that the record is no mere collection of ethnographic vignettes, instead a body of data that requires macroarchaeological approaches. Archaeology’s pending conceptual revolution in part is a legacy of Dibble’s thought.
Training for Recovery: Impact of Sprint Interval Training on Recovery Dynamics and Aerobic Performance in Kickboxing Athletes
Authors: Hall Andy , Williams Ashley K. , Babraj John 
Published: May 2024

Abstract
Purpose
Recovery within and between rounds is crucial to combat sports performance. We sought to determine whether sprint interval training (SIT) improves recovery dynamics and aerobic performance.

Methods
Eleven male kickboxing athletes (26 ± 5 years; body mass index 25 ± 3 kg/m2) were recruited. Participants were tested three times for VO2peak/time to exhaustion and critical power; baseline, 3 weeks control, 3 weeks of SIT (8 × 10 s lower body sprints followed by a maximum of 10 min recovery before completing 8 × 10 s upper body sprints). During SIT session 1 and 9 continuous gas analysis was performed.

Results
There was a significant reduction in recovery time between lower and upper body sprints with training (session 1: 441 ± 150 s; session 9: 268 ± 10 s; P < 0.01; d = 2.77) and change in oxygen off-kinetics amplitude (session1: 3.0 ± 0.7 L/min, session 9: 3.6 ± 1.0 L/min; P < 0.05; d = − 1.77), VO2 end (session 1: 0.59 ± 0.19 L/min, session 9: 0.81 ± 0.21 L/min; P < 0.05, d = − 0.90), time constant (session 1: 81 ± 21 s; session 9: 60 ± 11 s; P < 0.05; d = 1.03). Following training there was a significant improvement in critical power (P < 0.05; η2p = 0.72) time to exhaustion (P < 0.05; η2p = 0.30) but not VO2peak (P > 0.05).

Conclusion
SIT improves recovery time associated and aerobic performance associated with improved oxygen off-kinetics. Therefore, training needs to focus on improving oxygen off-kinetics to enhance combat performance.
Does corporate governance moderate the impact of earnings management on capital structure of the listed corporations on Palestine and Amman Bourses
Authors: Abualhassan Shms Alduha , Nour Abdulnaser I. , Atout Sameh , Daraghma Zahran , Jebreen Kamel , Alzebdieh Rami Moh’d 
Published: May 2024

AbstractThe purpose of this research is to investigate the moderating role of corporate governance on the relationship between earnings management and debt level in capital structure. The paper used a hypothesis-testing research approach to gather data from the annual reports of 13 industrial companies listed on Palestine Exchange and 25 Jordanian companies listed on Amman Stock Exchange from 2013 to 2020. Descriptive and inferential statistics were employed, along with correlation analysis to evaluate linear relationships between variables. The fixed and random effect regressions were utilized to develop the research model. In the case of Palestinian manufacturing firms, the results revealed that Earnings Management (EM) had a significant negative impact on debt level. According to the moderating role of Corporate Governance (CG), larger boards and the existence of female members on the board of directors causes an increase in the high-leverage impact of EM, whereas CEO duality mitigates the high-leverage impact. However, in the case of Jordanian manufacturing firms, EM showed an insignificant impact on debt level. Regarding the moderating role of CG, it was proved that the presence of female members on the board of directors increased the firm’s reliance on debt financing as a result of EM practices, while institutional investors mitigate the effect of EM on debt financing, leading to a decrease in reliance on debt. The findings of this research are suitable for the regulators while formulating policies on the Corporate Governance and the Impact of Earnings Management on Capital Structure. These findings have guided the policymakers that they should enhance their focus on Palestine and Jordan companies to test Corporate Governance Moderates the Impact of Earnings Management on Capital Structure. This study is also helpful for the new researcher while investigating this area in the future.
Near-infrared two-photon absorption and excited state dynamics of a fluorescent diarylethene derivative
Authors: Sotome Hikaru , Nagasaka Tatsuhiro , Konishi Tatsuki , Kamada Kenji , Morimoto Masakazu , Irie Masahiro , Miyasaka Hiroshi 
Published: May 2024

Abstract
Near-infrared two-photon absorption and excited state dynamics of a fluorescent diarylethene (fDAE) derivative were investigated by time-resolved absorption and fluorescence spectroscopies. Prescreening with quantum chemical calculation predicted that a derivative with methylthienyl groups (mt-fDAE) in the closed-ring isomer has a two-photon absorption cross-section larger than 1000 GM, which was experimentally verified by Z-scan measurements and excitation power dependence in transient absorption. Comparison of transient absorption spectra under one-photon and simultaneous two-photon excitation conditions revealed that the closed-ring isomer of mt-fDAE populated into higher excited states deactivates following three pathways on a timescale of ca. 200 fs: (i) the cycloreversion reaction more efficient than that by the one-photon process, (ii) internal conversion into the S1 state, and (iii) relaxation into a lower state (S1’ state) different from the S1 state. Time-resolved fluorescence measurements demonstrated that this S1’ state is relaxed to the S1 state with the large emission probability. These findings obtained in the present work contribute to extension of the ON–OFF switching capability of fDAE to the biological window and application to super-resolution fluorescence imaging in a two-photon manner.

Graphical Abstract
A boundary element analysis of quasi-potential inviscid incompressible flow in multiply connected airfoil wing
Authors: Fahmy Mohamed Abdelsabour , Alzubaidi Mohammed Hassan M. 
Published: May 2024

AbstractThe quasi-potential flow in a doubly linked airfoil wing with a sharp trailing edge can be solved using a high-order boundary-element method (BEM). A bicubic Hermite spline interpolation is used to express the unknown, with node derivatives given by finite difference method. The revolutionary traits apply to bleeding-edge settings; specifically, challenges relating to the three-dimensional problem of multiply connected domains are investigated. Numerical validation examples were utilized to assess the implemented BEM approach.