bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Hydraulic Evolution of Groundwater‐Fed Pit Lakes After Mine Closure
Authors: Moser Birte , Cook Peter G. , Miller Anthony D. , Dogramaci Shawan , Wallis Ilka 
Published: June 2024

AbstractOpen pit mining frequently requires regional water tables to be lowered to access ore deposits. When mines close, dewatering ceases allowing the water table to recover. In arid and semi‐arid mining regions, the developing pit lakes are predominantly fed by groundwater during this recovery phase and pit lakes develop first into “terminal sinks” for the surrounding groundwater system. With time, the re‐establishment of regional hydraulic gradients can cause pit lakes to develop into throughflow systems, in which pit lake water outflows into adjacent aquifers. In this study, we use numerical groundwater modeling to aid process understanding of how regional hydraulic gradients, aquifer properties, net evaporation rates, and pit geometry determine the hydraulic evolution of groundwater‐fed pit lakes. We find that before the recovery of the regional water table to its new equilibrium, pit lakes frequently transition to throughflow systems. Throughflow from pit lakes to downstream aquifers can develop within two decades following cessation of dewatering even under low hydraulic gradients (e.g., 5 × 10−4) or high net evaporation rates (e.g., 2.5 m/year). Pit lakes remain terminal sinks only under suitable combinations of high evaporation rates, low hydraulic gradients, and low hydraulic conductivities. In addition, we develop an approximate analytical solution for a rapid assessment of the hydraulic status of pit lakes under steady‐state conditions. Understanding whether pit lakes remain terminal sinks or transition into throughflow systems largely determines the long‐term water quality of pit lakes and downstream aquifers. This knowledge is fundamental for mine closure and planning post‐mining land use.
Oral surgery in people with inherited bleeding disorder: A retrospective study
Authors: Fribourg Emma , Castet Sabine , Fénelon Mathilde , Huguenin Yoann , Fricain Jean‐Christophe , Chuy Virginie , Catros Sylvain 
Published: June 2024

AbstractIntroductionThe objectives were to describe the peri‐operative management of people with inherited bleeding disorders in oral surgery and to investigate the association between type of surgery and risk of developing bleeding complications.Materials and MethodsThis retrospective observational study included patients with haemophilia A or B, von Willebrand disease, Glanzmann thrombasthenia or isolated coagulation factor deficiency such as afibrinogenemia who underwent osseous (third molar extraction, ortho‐surgical traction, dental implant placement) or nonosseous oral surgery between 2014 and 2021 at Bordeaux University Hospital (France). Patients and oral surgery characteristics were retrieved from medical records. Odds ratio (OR) and 95% confidence interval (CI) were estimated using logistic regression.ResultsOf the 83 patients included, general anaesthesia was performed in 16%. Twelve had a bleeding complication (14.5%) including six after osseous surgery. The most serious complication was the appearance of anti‐FVIII inhibitor in a patient with moderate haemophilia A. All bleeding complications were managed by a local treatment and factor injections where indicated. No association was observed between type of surgery (osseous vs. nonosseous) and risk of bleeding complications after controlling for sex, age, disease type and severity, multiple extractions, type of anaesthesia and use of fibrin glue (OR: 3.21, 95% CI: .69–14.88).ConclusionIn this study, we have observed that bleeding complications after oral surgery in people with inherited bleeding disorders were moderately frequent and easily managed. However, in this study, we observed a serious complication highlighting the necessity of a thorough benefit‐risk balance evaluation during the preoperative planning of the surgical and medical protocol.
The 2023 protocol for update to acute treatment of adults with migraine in the emergency department: The American Headache Society evidence assessment of parenteral pharmacotherapies
Authors: Robblee Jennifer , Zhao Xurong (Rachel) , Minen Mia T. , Friedman Benjamin W. , Cortel‐LeBlanc Miguel A. , Cortel‐LeBlanc Achelle , Orr Serena L. 
Published: June 2024

AbstractObjectivesThe primary objective of this proposed guideline is to update the prior 2016 guideline on parenteral pharmacotherapies for the management of adults with a migraine attack in the emergency department (ED).MethodsWe will conduct an updated systematic review and meta‐analysis using the 2016 guideline methodology to provide clinical recommendations. The same search strategy will be used for studies up to 2023, with a new search strategy added to capture studies of nerve blocks and sphenopalatine blocks. Medline, Embase, Cochrane, clinicaltrials.gov, and the World Health Organization International Clinical Trial Registry Platform will be searched. Our inclusion criteria consist of studies involving adults with a diagnosis of migraine, utilizing medications administered intravenously, intramuscularly, or subcutaneously in a randomized controlled trial design. Two authors will perform the selection of studies based on title and abstract, followed by a full‐text review. A third author will intervene in cases of disagreements. Data will be recorded in a standardized worksheet and subjected to verification. The risk of bias will be assessed using the American Academy of Neurology tool. When applicable, a meta‐analysis will be conducted. The efficacy of medications will be evaluated, categorizing them as “highly likely,” “likely”, or “possibly effective” or “ineffective.” Subsequently, clinical recommendations will be developed, considering the risk associated with the medications, following the American Academy of Neurology recommendation development process.ResultsThe goal of this updated guideline will be to provide guidance on which injectable medications, including interventional approaches (i.e., nerve blocks, sphenopalatine ganglion), should be considered effective acute treatment for adults with migraine who present to an ED.ConclusionsThe methods outlined in this protocol will be used in the design of a future systematic review and meta‐analysis‐informed guideline, which will then be assessed by and submitted for endorsement by the American Headache Society.
Deformation mechanism of glass microlenses and microlens arrays in contactless hot embossing
Authors: Yang Kang , Li Jianzhi , Gong Feng , Yang Gao 
Published: June 2024

AbstractContactless hot embossing has been demonstrated to possess the potential for cost‐effective production and precise mounting concepts in fabricating glass microlenses and microlens arrays due to the reduced difficulty of mold fabrication and the possibility of obtaining self‐aligned assemblies. This study aims to provide experimental evidence for understanding the forming mechanism of glass microlenses and microlens arrays in the contactless hot embossing process. The effects of process parameters, diameter and position of the micro‐holes, hole diameter, and pitch of the micro‐hole array mold on the filling deformation of glass in contactless hot embossing were comprehensively investigated. It is found that placing the micro‐hole farther away from the mold center renders decrease in both filling height and tip curvature but increase in the eccentricity of the embossed glass microlens. As a result, the formed glass microlens array shows a nonuniform distribution of filling height and tip curvature. Furthermore, reducing the pitch of micro‐hole array mold can significantly improve the uniformity of formed microlens array. Based on these experimental results, the forming mechanism of microlenses and microlens arrays in contactless hot embossing process is summarized. Finally, a glass microlens array with decent uniformity in the center area was hot embossed by using a SiC micro‐hole array mold.
Effects of ferroptosis‐related gene HSPB1 on acute myeloid leukemia
Authors: Yan Xue‐Shen , Sun Yu‐Jiao , Du Juan , Niu Wen‐Yan , Qiao Han , Yin Xiang‐Cong 
Published: June 2024

AbstractIntroductionThe purpose of this study was to investigate the effects and potential mechanisms of ferroptosis‐related gene heat shock protein beta‐1 (HSPB1) on acute myeloid leukemia (AML).MethodsThe RNA‐seq and clinical data of AML samples were obtained from the Genomic Data Commons database, and the FerrDb database was used to screen the marker, drive and suppressor of ferroptosis. Besides, DESeq2 was applied for differential expression analysis on AML samples and screening for differentially expressed genes (DEGs). The screened DEGs were subjected to the intersection analysis with ferroptosis‐related genes to identify the ferroptosis‐related DEGs. Next, the functional pathways of ferroptosis‐related DEGs were further be discussed by Gene Ontology as well as Kyoto Encyclopedia of Genes and Genomes enrichment analysis of DEGs. Additionally, lasso regression analysis was employed to determine the differential genes related to prognosis in patients with AML and the survival analysis was performed. Subsequently, quantitative real‐time polymerase chain reaction and western blot assay were applied to detect the mRNA and protein expression levels of HSPB1 in normal/AML bone marrow tissues and human normal (HS‐5)/AML (HL‐60) bone marrow cells, respectively. Furthermore, HSPB1 was knocked down to assess the expression changes of glutathione peroxidase 4 and acyl‐CoA synthetase long‐chain family member 4. Ultimately, the viability and oxidative stress levels of HL‐60 were analyzed by Cell Counting Kit‐8 and biochemical detection.ResultsA total of 4986 DEGs were identified in AML samples, with 3324 up‐regulated and 1662 down‐regulated. The enrichment analysis illustrated that ferroptosis‐related DEGs were significantly enriched in response to metal irons, oxidative stress, and other pathways. After lasso regression analysis, 17 feature genes related to the prognosis of patients with AML were obtained, with HSPB1 exhibiting a significant correlation. The reliability of our models was verified by Cox regression analysis and survival analysis of the hazard model. Furthermore, the outcomes of quantitative real‐time polymerase chain reaction and western blot showed that mRNA and protein expression levels of HSPB1 were significantly increased in the AML Group and HL‐60 cells. The knockdown of HSPB1 in HL‐60 cells reduced the protein level of glutathione peroxidase 4, increased the protein level of acyl‐CoA synthetase long‐chain family member 4, decreased the cell viability, and aggravated oxidative stress.ConclusionFerroptosis‐related gene HSPB1 is highly expressed in patients with AML. In addition, HSPB1 may be involved in the occurrence and development of AML by regulating oxidative stress and ferroptosis‐related pathways. This study provides new clues for further understanding of AML molecular mechanisms. Also, HSPB1 is expected to be a potential therapeutic target for AML in the future.
Homeland–diaspora nexus during crisis: Towards a transformed engagement model
Authors: Kalantzi Foteini 
Published: June 2024

AbstractHistorically, Greece perceived and approached its diaspora as a source of philanthropic funding, economic remittances and lobbying on matters of domestic and foreign policy interests. The 2009 economic crisis, the subsequent emigration wave, have added new meanings and dimensions to the Greek diaspora–homeland nexus. Drawing on qualitative analysis and process‐tracing, this article argues that the crisis has transformed the dynamics of the homeland–diaspora relation especially when it comes to political engagement from abroad. While investigating the reasons behind this transfiguration, the article examines the changing features of the Greek diaspora's political engagement, by examining the influence wielded by homeland political parties and by conducting an in‐depth analysis of the diasporic vote. The article also delves into the influence of technology to the emergence of transnational political engagement and the establishment of novel diaspora networks.
Mask‐related pressure injury prevention associated with non‐invasive ventilation: A systematic review
Authors: Emami Zeydi Amir , Zare‐Kaseb Akbar , Nazari Amir Mohamad , Ghazanfari Mohammad Javad , Sarmadi Sogand 
Published: June 2024

AbstractNoninvasive ventilation interfaces are one of the main factors contributing to pressure injuries caused by medical devices. Prevention is still the best course of action when discussing noninvasive ventilation‐induced pressure injuries. A systematic review was designed to summarize and analyse all published literature on strategies to prevent pressure injuries caused by masks in patients undergoing noninvasive ventilation. The protocol of the systematic review followed the PRISMA guideline. An extensive search from the beginning to May 16, 2023, using current articles in databases such as Web of Science (WOS), Scopus, PubMed, and Cochrane Library was conducted. Medical Subject Headings (MESH) were used as follows: “Pressure Injury,” “Noninvasive Ventilation,” “Prevention,” and “Pressure Sore.” Any language‐published studies that met the inclusion criteria were included in this review. A risk of bias assessment was conducted using the Joanna Briggs Institute tool, including evaluation methodologies for all studies. Database searches yielded 2546 articles, which were reduced to 23 that met our criteria after reviewing full texts. A narrative synthesis was conducted. As a result, type of interface (14 studies), dressings (4 studies), adjustment of mask leakage (1 study), humidity (1 study), positioning (1 study), and design of personalized masks (2 studies) seem to be a practical approach to prevent pressure injuries caused by masks in patients undergoing noninvasive ventilation. The results of our study show the effectiveness of preventive methods in reducing the incidence of pressure injuries caused by masks. Given the significant occurrence of pressure injury related to noninvasive ventilation and the crucial role of prevention and treatment, it is imperative to conduct more rigorous studies to ascertain the efficacy of each strategy.
Pharmacologic blockade of nicotinic receptors in the suprachiasmatic nucleus increases ovarian atresia and inhibits follicular growth
Authors: Vieyra Elizabeth , Calderón Roberto , Linares Rosa , Rosas Gabriela , Ramírez Deyra A. , Espinoza Julieta A. , Chaparro Andrea , Silva Carlos‐Camilo , Domínguez Roberto , Morales‐Ledesma Leticia 
Published: June 2024

AbstractReproduction in all mammalian species depends on the growth and maturation of ovarian follicles, that is, folliculogenesis. Follicular development can culminate with the rupture of mature follicles and the consequent expulsion of their oocytes (ovulation) or in atresia, characterized by the arrest of development and eventual degeneration. These processes are regulated by different neuroendocrine signals arising at different hypothalamic nuclei, including the suprachiasmatic nucleus (SCN). In the later, the activation of muscarinic receptors (mAChRs) and nicotinic receptors (nAChRs) by acetylcholine is essential for the regulation of the pre‐ovulatory signals that stimulate the rupture of mature follicles. To evaluate the participation of the nAChRs in the SCN throughout the oestrous cycle in the regulation of the hypothalamic–pituitary–ovarian axis. For this purpose, 90‐day‐old adult female rats in metoestrus, dioestrus, proestrus or oestrus were microinjected into the left‐ or right‐SCN with 0.3 μL of saline solution as vehicle or with 0.225 μg of mecamylamine (Mec), a non‐selective antagonist of the nicotinic receptors, diluted in 0.3 μL of vehicle. The animals were sacrificed when they presented vaginal cornification, indicative of oestrus stage, and the effects of the unilateral pharmacological blockade of the nAChRs in the SCN on follicular development, ovulation and secretion of oestradiol and follicle‐stimulating hormone (FSH) were evaluated. The microinjection of Mec decreased the serum levels of FSH, which resulted in a lower number of growing and healthy follicles and an increase in atresia. The higher percentage of atresia in pre‐ovulatory follicles was related to a decrease in the number of ova shed and abnormalities in oestradiol secretion. We also detected asymmetric responses between the left and right treatments that depended on the stage of the oestrous cycle. The present results allow us to suggest that during all the stages of the oestrous cycle, cholinergic signals that act on the nAChRs in the SCN are pivotal to modulate the secretion of gonadotropins and hence the physiology of the ovaries. Further research is needed to determine if such signals are generated by the cholinergic neurons in the SCN or by cholinergic afferents to the SCN.
Main and interactive effects of discrimination, parent racial/ethnic socialization, and internalizing symptomology on BIPOC teens' ethnic‐racial identity
Authors: Takamasa Emily J. , Fraser Ashley M. , Rogers Adam A. 
Published: June 2024

AbstractResearch suggests that BIPOC (Black, Indigenous, People of Color) adolescents have the best developmental outcomes when strong, positive ethnic‐racial identity (ERI) is acknowledged and embraced. This study investigated whether discrimination, internalizing symptomology, parent socialization, and/or interactions of these variables were associated with adolescent ERI, specifically in exploration, resolution, and affirmation, to illuminate nuanced ways BIPOC youth can achieve positive ERI. Recruited from third‐party research panels, surveyed participants were adolescents (Mage = 15.28; 51.6% male) of diverse ethnic/racial groups and socioeconomic backgrounds from all regions of the United States. Overall, results showed that there were four significant main effects on ERI: a negative relation between internalizing symptomology and exploration, a positive relation between parent socialization and exploration, a positive relation between parent socialization and resolution, and a negative relation between internalizing symptomology and affirmation. There were also two significant interactive effects such that (1) discrimination had a stronger negative relation with affirmation under condition of high internalizing, and (2) parent socialization had a stronger positive relation with affirmation under condition of high internalizing. Results show development of ERI in adolescence is subject to multiple, interactive influences. Main and interactive effects highlight the contextual role that mental health implicates for youth of color. Implications for parents and practitioners are discussed.
Cementum and enamel surface mimicry influences soft tissue cell behavior
Authors: Bellon Benjamin , Pippenger Benjamin , Stähli Alexandra , Degen Martin , Parisi Ludovica 
Published: June 2024

AbstractAimsTo test whether titanium surface roughness disparity might be used to specifically guide the behavior of gingiva fibroblasts and keratinocytes, thereby improving the quality of soft tissue (ST) integration around abutments.MethodsTitanium discs resembling the roughness of enamel (M) or cementum (MA) were created with normal or increased hydrophilicity and used as substrates for human fibroblasts and keratinocytes. Adhesion and proliferation assays were performed to assess cell‐type specific responses upon encountering the different surfaces. Additionally, immunofluorescence and qPCR analyses were performed to study more in depth the behavior of fibroblasts and keratinocytes on MA and M surfaces, respectively.ResultsWhile enamel‐like M surfaces supported adhesion, growth and a normal differentiation potential of keratinocytes, cementum‐emulating MA surfaces specifically impaired the growth of keratinocytes. Vice versa, MA surfaces sustained regular adhesion and proliferation of fibroblasts. Yet, a more intimate adhesion between fibroblasts and titanium was achieved by an increased hydrophilicity of MA surfaces, which was associated with an increased expression of elastin.ConclusionThe optimal titanium implant abutment might be achieved by a bimodal roughness design, mimicking the roughness of enamel (M) and cementum with increased hydrophilicity (hMA), respectively. These surfaces can selectively elicit cell responses favoring proper ST barrier by impairing epithelial downgrowth and promoting firm adhesion of fibroblasts.
Seasonal dietary changes relate to gut microbiota composition depending on the host species but do not correlate with gut microbiota diversity in arthropod‐eating lizards
Authors: Hernández Mauricio , Ancona Sergio , Hereira‐Pacheco Stephanie , Díaz de la Vega‐Pérez Aníbal H. , Alberdi Antton , Navarro‐Noya Yendi E. 
Published: June 2024

AbstractThe animal gut microbiota is strongly influenced by environmental factors that shape their temporal dynamics. Although diet is recognized as a major driver of gut microbiota variation, dietary patterns have seldom been linked to gut microbiota dynamics in wild animals. Here, we analysed the gut microbiota variation between dry and rainy seasons across four Sceloporus species (S. aeneus, S. bicanthalis, S. grammicus and S. spinosus) from central Mexico in light of temporal changes in diet composition. The lizard microbiota was dominated by Firmicutes (now Bacillota) and Bacteroidota, and the closely related species S. aeneus and S. bicanthalis shared a great number of core bacterial taxa. We report species‐specific seasonal changes in gut microbiota diversity and composition: greater alpha diversity during the dry compared to the rainy season in S. bicanthalis, the opposite pattern in S. aeneus, and no seasonal differences in S. grammicus and S. spinosus. Our findings indicated a positive association between gut bacterial composition and dietary composition for S. bicanthalis and S. grammicus, but bacterial diversity did not increase linearly with dietary richness in any lizard species. In addition, seasonality affected bacterial composition, and microbial community similarity increased between S. aeneus and S. bicanthalis, as well as between S. grammicus and S. spinosus. Together, our results illustrate that seasonal variation and dietary composition play a role in shaping gut microbiota in lizard populations, but this is not a rule and other ecological factors influence microbiota variation.
Snow‐ or ice‐covered road detection in winter road surface conditions using deep neural networks
Authors: Moroto Yuya , Maeda Keisuke , Ogawa Takahiro , Haseyama Miki 
Published: June 2024

AbstractTraffic accidents occur frequently in cold and snow‐ or ice‐covered regions due to weather changes that occur during the winter season. To detect the snow‐ or ice‐covered roads in road surface conditions, road surface images captured using fixed‐point cameras installed along the route are sufficient. This paper proposes a snow‐ or ice‐covered road detection method that uses the deep convolutional autoencoding Gaussian mixture model (DCAGMM) with structural similarity (SSIM). The DCAGMM method, which is an unsupervised anomaly detection method, is unaffected by imbalance in the training data. In addition, the end‐to‐end convolutional neural network implemented in the DCAGMM enables the capture of the unique characteristics of the road surface images. Finally, by reconstructing the input images as normal images, the comparison of the input and reconstructed images enables identification of snow‐ or ice‐covered road areas without requiring pixel‐level annotations. Furthermore, the road surface images include complex characteristics for reconstruction, and the SSIM‐based reconstruction error allows us to preserve the image quality of the reconstructed image. Experimental results obtained on real‐world road surface images demonstrate the effectiveness of the proposed method.