bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of Iron Deficiency Using 3 Definitions Among Women in the US and Canada
Authors: Barton James C. , Wiener Howard W. , Barton Jackson C. , Acton Ronald T. 
Published: June 2024

ImportanceThe prevalence of iron deficiency varies widely according to how it is defined.ObjectiveTo compare the prevalence of iron deficiency among women using 3 different definitions.Design, Setting, and ParticipantsThe cross-sectional Hemochromatosis and Iron Overload Screening Study (HEIRS; 2000-2006) evaluated the prevalence, determinants, and outcomes of hemochromatosis and other iron-related disorders. Multiethnic, primary care–based screening (2001-2003) was performed at 5 field centers (4 in the US and 1 in Canada). Volunteer women aged 25 years and older were recruited at primary care venues associated with the field centers. Data were analyzed from June to December 2023.Main Outcomes and MeasuresMeasures included transferrin saturation, serum ferritin level, and self-reported age, pregnancy, and race and ethnicity. Three iron deficiency definitions were studied: (1) combined transferrin saturation less than 10% and serum ferritin less than 15 ng/mL (HEIRS), (2) serum ferritin less than 15 ng/mL (World Health Organization [WHO]), and (3) serum ferritin less than 25 ng/mL (a threshold for iron-deficient erythropoiesis [IDE]).ResultsAmong 62 685 women (mean [SD] age, 49.58 [14.27] years), 1957 women (3.12%) had iron deficiency according to the HEIRS definition, 4659 women (7.43%) had iron deficiency according to the WHO definition, and 9611 women (15.33%) had iron deficiency according to the IDE definition. Among 40 381 women aged 25 to 54 years, 1801 women (4.46%) had iron deficiency according to HEIRS, 4267 women (10.57%) had iron deficiency according to WHO, and 8573 women (21.23%) had iron deficiency according to IDE. Prevalence rates of iron deficiency among 2039 women aged 25 to 44 years who reported pregnancy were 5.44% (111 women) according to HEIRS, 18.05% (368 women) according to WHO, and 36.10% (736 women) according to IDE. Iron deficiency prevalence by the 3 respective definitions increased significantly in each racial and ethnic group and was significantly higher among Black and Hispanic participants than Asian and White participants. The relative iron deficiency prevalence among the 62 685 women increased 2.4-fold (95% CI, 2.3-2.5; P &amp;lt; .001) using the WHO definition and increased 4.9-fold (95% CI, 4.7-5.2; P &amp;lt; .001) using the IDE definition.Conclusions and RelevanceThree definitions of iron deficiency were associated with significantly different prevalence of iron deficiency in women, regardless of self-reported age, pregnancy, or race and ethnicity. Using higher serum ferritin thresholds to define iron deficiency could lead to diagnosis and treatment of more women with iron deficiency and greater reduction of related morbidity.
Voltage‐Driven Fluorine Motion for Novel Organic Spintronic Memristor
Authors: Nachawaty Abir , Chen Tongxin , Ibrahim Fatima , Wang Yuchen , Hao Yafei , Dalla Francesca Kevin , Tyagi Priyanka , Da Costa Antonio , Ferri Anthony , Liu Chuanchuan , Li Xiaoguang , Chshiev Mairbek , Migot Sylvie , Badie Laurent , Jahjah Walaa , Desfeux Rachel , Le Breton Jean‐Christophe , Schieffer Philippe , Le Pottier Arnaud , Gries Thomas , Devaux Xavier , Lu Yuan 
Published: June 2024

AbstractIntegrating tunneling magnetoresistance (TMR) effect in memristors is a long‐term aspiration because it allows to realize multifunctional devices, such as multi‐state memory and tunable plasticity for synaptic function. However, the reported TMR in different multiferroic tunnel junctions is limited to 100%. This work demonstrates a giant TMR of −266% in La0.6Sr0.4MnO3(LSMO)/poly(vinylidene fluoride)(PVDF)/Co memristor with thin organic barrier. Different from the ferroelectricity‐based memristors, this work discovers that the voltage‐driven florine (F) motion in the junction generates a huge reversible resistivity change up to 106% with nanosecond (ns) timescale. Removing F from PVDF layer suppresses the dipole field in the tunneling barrier, thereby significantly enhances the TMR. Furthermore, the TMR can be tuned by different polarizing voltage due to the strong modification of spin‐polarization at the LSMO/PVDF interface upon F doping. Combining of high TMR in the organic memristor paves the way to develop high‐performance multifunctional devices for storage and neuromorphic applications.
Organocatalytic Enantioselective Synthesis of Inherently Chiral Calix[4]arenes
Authors: Jiang Yu‐Kun , Tian Yong‐Le , Feng Jia , Zhang Huan , Wang Lei , Yang Wei‐Ao , Xu Xing‐Dong , Liu Ren‐Rong 
Published: June 2024

AbstractInherently chiral calix[4]arenes are an excellent structural scaffold for enantioselective synthesis, chiral recognition, sensing, and circularly polarized luminescence. However, their catalytic enantioselective synthesis remains challenging. Herein, we report an efficient synthesis of inherently chiral calix[4]arene derivatives via cascade enantioselective cyclization and oxidation reactions. The three‐component reaction features a broad substrate scope (33 examples), high efficiency (up to 90 % yield), and excellent enantioselectivity (>95 % ee on average). The potential applications of calix[4]arene derivatives are highlighted by their synthetic transformation and a detailed investigation of their photophysical and chiroptical properties.
Halogen‐Bonded Organic Frameworks (XOFs) Based on N⋅⋅⋅Br+⋅⋅⋅N Bonds: Robust Organic Networks Constructed by Fragile Bonds
Authors: Bai Xuguan , Tian Zhennan , Dong Hongqiang , Xia Ning , Zhao Jiahao , Sun Penghao , Gong Guanfei , Wang Jike , Wang Lu , Li Haohu , Chen Shigui 
Published: June 2024

AbstractOrganic frameworks face a trade‐off between the framework stability and the bond dynamics, which necessitates the development of innovative linkages that can generate stable frameworks without hindering efficient synthesis. Although iodine(I)‐based halogen‐bonded organic frameworks (XOFs) have been developed, constructing XOFs based on bromine(I) is desirable yet challenging due to the high sensitivity of bromine(I) species. In this work, we present the inaugural construction of stable bromine(I)‐bridged two‐dimensional (2D) halogen‐bonded organic frameworks, XOF(Br)−TPy−BF4/OTf, based on sensitive [N⋅⋅⋅Br⋅⋅⋅N]+ halogen bonds. The formation of XOF(Br)−TPy−BF4/OTf was monitored by 1H NMR, XPS, IR, SEM, TEM, HR‐TEM, SEAD. Their framework structures were established by the results from PXRD, theoretical simulations and SAXS. More importantly, XOF(Br) displayed excellent chemical and thermal stabilities. They exhibited stable two‐dimensional framework structures in various organic solvents and aqueous media, even over a wide pH range (pH 3–12), while the corresponding model compounds BrPy2BF4/OTf decomposed quickly even in the presence of minimal water. Furthermore, the influence of the counterions were investigated by replacing BF4 with OTf, which improved the stability of XOF(Br). This characteristic enabled XOF(Br) to serve as an efficient oxidizing reagent in aqueous environments, in contrast with the sensitivity of BrPy2BF4/OTf, which performed well only in organic media. This study not only deepens our fundamental understanding of organic frameworks but also opens new avenues for the development and application of multifunctional XOFs.
Sex differences in correlates of suicide attempts in Chinese Han first‐episode and drug‐naïve major depressive disorder with comorbid subclinical hypothyroidism: A cross‐sectional study
Authors: Tian Xue , Liu Xiao‐En , Bai Fengfeng , Li Meijuan , Qiu Yuying , Jiao Qingyan , Li Jie , Zhang Xiang‐Yang 
Published: June 2024

AbstractBackgroundThis study aimed to investigate sex differences in risk factors for suicide attempts in first‐episode and drug naive (FEDN) major depressive disorder (MDD) with comorbid subclinical hypothyroidism (SCH).MethodsA total of 1034 FEDN MDD patients with comorbid SCH were enrolled. The Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and Positive and Negative Syndrome Scale (PANSS) positive subscale were used to assess patients’ symptoms. Thyroid hormone levels and metabolic parameters were measured.ResultsMDD patients with SCH had a significantly higher risk of suicide attempts than those without SCH (25.4% vs. 12.2%). Logistic regression showed that HAMA score, thyroid stimulating hormone (TSH) levels, and thyroid peroxidase antibody (TPOAb) levels were significantly associated with an increased risk for suicide attempts in both male and female MDD patients comorbid SCH, while low‐density lipoprotein cholesterol (LDL‐C) was significantly associated with an increased risk for suicide attempts only in male patients, HAMD score and systolic blood pressure were significantly associated with an increased risk for suicide attempts only in female patients.ConclusionSCH comorbidities may increase suicide attempts in MDD patients. Our results showed significant sex differences in clinical and metabolic factors associated with suicide attempts among FEDN MDD patients with comorbid SCH, highlighting appropriate sex‐based preventive interventions are needed.
Anatomical evaluation of the superficial medial collateral ligament distal tibial attachment of the knee
Authors: Kikuchi Keishiro , Tabuchi Kosuke , Inoue Seiichi , Yamashita Akihiro , Kinouchi Shotaro , Hashida Ryuki , Iwanaga Joe , Watanabe Koichi , Tubbs R. Shane , Okawa Takahiro , Hiraoka Koji 
Published: June 2024

AbstractThis study aimed to evaluate the superficial medial collateral ligament distal tibial attachment (sMCL‐dTA) morphologically and morphometrically. Seventeen unpaired formalin‐fixed cadaveric knees were used. The sMCL was divided into anterior and posterior sections in the paracoronal plane along the midline of the sMCL. The distance from the medial edge of the tibial plateau and the joint line to the proximal margin, center, and distal margin of the sMCL‐dTA and the length of the sMCL‐dTA were measured in the anterior section, respectively. The sMCL‐dTA was histologically observed in the posterior section with hematoxylin and eosin and Masson's trichrome staining. The distance from the medial edge of the tibial plateauto the proximal margin, center, and distal margin of the sMCL‐dTA were 38.1 ± 4.2, 49.7 ± 4.4, and 61.5 ± 5.1 mm, respectively. The perpendicular distance from the joint line to the proximal margin, center, and distal margin of the sMCL‐dTA were 36.1 ± 4.0, 47.4 ± 4.2, and 59.1 ± 4.8 mm, respectively. The length of the sMCL‐dTA was 23.6 ± 3.2 mm. Histologically, the sMCL‐dTA was formed by two layers of collagen fibers: the unidirectional fibrous layer and the multidirectional fibrous layer. The respective thicknesses of the two layers both decreased distally. The anatomical location, the length, and the attachment morphology of sMCL‐dTA have been clarified using human cadaveric knees. Anatomical data in the present study contribute to the quality of surgery associated with sMCL‐dTA.
Iminosugar‐Dihydroazulenes as Mutant L444P Glucocerebrosidase Enhancers
Authors: Davighi Maria Giulia , Clemente Francesca , Andreasen Emilie Sperling , Nielsen Mogens Brøndsted , Matassini Camilla , Goti Andrea , Morrone Amelia , Paoli Paolo , Cardona Francesca , Cacciarini Martina 
Published: June 2024

AbstractA remarkable enhancer of human glucocerebrosidase enzyme (GCase) was identified among a set of dihydroazulene‐tagged iminosugars. An unprecedented 3.9‐fold increase in GCase activity was detected on fibroblasts bearing the homozygous L444P mutation, which is frequently associated with neuronopathic Gaucher forms, and which commonly results refractory to chaperone‐induced refolding.
Selective Photocatalytic Oxidation of Thioethers to Sulfoxides Mediated by a Carbon Nanotube‐Porphyrin Nanohybrid
Authors: Tchuiteng Kouatchou Joël Armel , Farah Joseph , Malloggi Florent , Gravel Edmond , Doris Eric 
Published: June 2024

AbstractA heterogeneous photocatalyst was assembled through electrostatic immobilization of a cationic porphyrin at the surface of functionalized carbon nanotubes. The supra‐molecular nanohybrid catalyst was valorized in the aerobic photo‐oxidation of sulfides to the corresponding sulfoxides. The process operated selectively under visible light, with low catalytic loading, in water as the solvent, and the catalyst was readily recycled and reused.
Electrospun carbon nanofiber‐supported V2O3 with enriched oxygen vacancies as a free‐standing high‐rate anode for an all‐vanadium‐based full battery
Authors: Lai Qi , Yin Bincen , Dou Yu , Zhang Qing , Zhu Yunhai , Yang Yingkui 
Published: June 2024

AbstractSynergistic regulation of hierarchical nanostructures and defect engineering is effective in accelerating electron and ion transport for metal oxide electrodes. Herein, carbon nanofiber‐supported V2O3 with enriched oxygen vacancies (OV‐V2O3@CNF) was fabricated using the facile electrospinning method, followed by thermal reduction. Differing from the traditional particles embedded within carbon nanofibers or irregularly distributed between carbon nanofibers, the free‐standing OV‐V2O3@CNF allows for V2O3 nanosheets to grow vertically on one‐dimensional (1D) carbon nanofibers, enabling abundant active sites, shortened ion diffusion pathway, continuous electron transport, and robust structural stability. Meanwhile, density functional theory calculations confirmed that the oxygen vacancies can promote intrinsic electron conductivity and reduce ion diffusion energy barrier. Consequently, the OV‐V2O3@CNF anode delivers a large reversible capacity of 812 mAh g−1 at 0.1 A g−1, superior rate capability (405 mAh g−1 at 5 A g−1), and long cycle life (378 mAh g−1 at 5 A g−1 after 1000 cycles). Moreover, an all‐vanadium full battery (V2O5//OV‐V2O3@CNF) was assembled using an OV‐V2O3@CNF anode and a V2O5 cathode, which outputs a working voltage of 2.5 V with high energy density and power density, suggesting promising practical application. This work offers fresh perspectives on constructing hierarchical 1D nanofiber electrodes by combining defect engineering and electrospinning technology.
Carbon–carbon triple bond‐containing materials for photo(electro)catalytic solar hydrogen production
Authors: Li Wenyan , Lu Yang , Tang Yawen , Sun Hanjun 
Published: June 2024

AbstractThe use of solar energy to produce hydrogen has been one of the research hotspots in recent years. With the continuous exploitation of solar hydrogen evolution, the performance of photo(electro)catalysts has been greatly optimized. However, the solar‐driven hydrogen production for most semiconductors, especially for organic semiconductors, is limited due to the lack of active centers and serious electron–hole recombination. Recently, it has been reported that carbon‐carbon triple bonds (C≡C) can function as active sites for hydrogen evolution, and diacetylenic moiety in organic semiconductors is able to increase carrier migration as well. Therefore, organic semiconductors containing C≡C have attracted considerable attention in the past few years. In this review, organic materials or organic–inorganic hybrids containing C≡C for photo(electro)catalytic solar hydrogen production are classified first, including graphdiyne, conjugated acetylene polymers, some covalent organic frameworks, and metal–organic frameworks. After that, the structure, properties, and advantages and disadvantages of C≡C‐containing materials are introduced and summarized. Apart from these, this review also presents advances in materials containing C≡C in the field of solar hydrogen generation. Finally, perspectives on the future development of C≡C‐containing materials in the field of solar hydrogen generation are also briefly anticipated. This review provides pertinent insights into the main challenges and potential advances in the organic semiconductors for solar‐driven hydrogen production, which will also greatly contribute to other photo(electro)catalytic reactions.
A qualitative study of Black breast cancer previvors' and survivors' experiences after positive genetic testing
Authors: Sud Malika , Stallings Erika , Wang Catharine , Sosa Lillian T. 
Published: June 2024

AbstractBlack women have a disproportionately high mortality rate from breast cancer, which is likely influenced by an intersection of environmental, cultural, economic, and social factors. Few published studies capture the experiences of Black women after a genetic diagnosis associated with increased risk for breast cancer. This study aims to explore the perspectives and experiences of Black women who carry a pathogenic variant associated with increased breast cancer risk and identify barriers to care for this population. We conducted semi‐structured interviews with 16 participants with and without histories of breast cancer. The sample included representation across a range of demographic groups (e.g., income level, employment status, insurance status, and education level). Reflexive thematic analysis was the methodology used to analyze data. Five major themes emerged from participants' descriptions of their experiences during and after genetic testing: (1) searching for representation; (2) information enabling agency; (3) healthcare providers as facilitators or barriers to care; (4) self‐identity impacting disclosure; and (5) evolving mental health and coping strategies. Participants identified barriers to care including challenging or misinformed healthcare providers, medical racism, and a lack of Black representation in the cancer community. This work deepens our understanding of the nuanced experiences of Black women across the continuum of cancer care, illustrates unmet needs, and provides a foundation for future research that includes the perspectives of Black women.
Development and verification of the Korean version of the genetic counseling self‐efficacy scale
Authors: Tak Sunhee , Lee Beom Hee , Choi In Hee 
Published: June 2024

AbstractA self‐reported Genetic Counseling Self‐Efficacy Scale (GCSES) was developed in English to measure genetic counselors' self‐efficacy, a factor known to affect their job performance. This study verified the reliability and validity of the GCSES for use in Korea. The scale was translated and back‐translated into Korean for cultural fit verification. Expert analysis was performed to ensure content validity. For construct validity, a confirmatory factor analysis of the six‐factor structures of the GCSES and an exploratory factor analysis (EFA) of the K‐GCSES were conducted. To confirm the convergent validity and discriminant validity of the items, a multitrait/multi‐item matrix analysis of the relationship between items and subscales was conducted. The reliability was evaluated by examining internal consistency and test–retest reliability. A total of 62 participants were recruited from certified genetic counselors associated with the Korean Society of Medical Genetics and Genomics and from four graduate schools offering genetic counseling programs. Confirmatory factor analysis showed an inadequate fit to the original GCSES structure. Through EFA, three‐factor structures were identified: “counseling competence and psychosocial skills,” “genetic testing,” and “information gathering.” Of the original 38 GCSES items, five were removed due to low factor loadings and small inter‐item correlations. The item convergent validity and discriminant validity of the Korean version of the GCSES were established, and the correlation between the subfactors showed statistical significance (0.711–0.983). Cronbach's alpha was 0.985, and the intraclass correlation coefficient ranged from 0.882 to 0.897, securing reliability. The K‐GCSES has a three‐factor structure with acceptable reliability and sufficient validity. Differences in the factor structure between the K‐GCSES and GCSES may be due to cultural factors. K‐GCSES can be used as a tool to evaluate the competence of genetic counselors and genetic counseling students in Korea and to improve the quality of professionalism and education.
Thermodynamically consistent derivation of excess Raman spectra
Authors: Willger Miriam , Braeuer Andreas Siegfried 
Published: June 2024

AbstractAttempting to compute the excess Raman spectra, the authors found that the method of spectral normalization greatly influences not only the intensity but also the shape of the excess spectra. We here present a method for the computation of normalized excess Raman spectra that is regarded as thermodynamically consistent. In the presented method, the normalized excess Raman spectra are computed from molar Raman spectra, which cannot be measured directly. It is therefore described how they can be obtained from intensity‐normalized Raman spectra and a regression of mixture Raman spectra.
Fabrication and characterization of bovine serum albumin–phycocyanobilin conjugate: effect on antioxidant and ligand‐binding properties
Authors: Radomirovic Mirjana , Gligorijevic Nikola , Stanic‐Vucinic Dragana , Nikolic Milan , Cirkovic Velickovic Tanja 
Published: June 2024

AbstractBACKGROUNDPhycocyanobilin (PCB) is an open‐chain blue tetrapyrrole chromophore of C‐phycocyanin (C‐PC), a major chromoprotein derived from the cyanobacterium Arthrospira platensis having numerous health‐promoting effects. Relying on the ability of PCB to attach to the sulfhydryl group of proteins, we propose a new method for covalent attachment of PCB to bovine serum albumin (BSA) as a means of its functionalization.RESULTSTraut's reagent (TR, 2‐iminothiolane), modifying lysine residues, was used to optimize the introduction of sulfhydryl groups in BSA. A higher degree of BSA thiolation by TR induces more profound alterations of its structure, resulting in minor oligomerization and aggregation. A 50‐fold molar excess of TR was found to be the optimal, balancing thiolation level and adverse effect on protein structure. PCB was covalently attached to newly introduced sulfhydryl groups at pH 9 at 20‐fold PCB/BSA ratio. An increase in the TR/BSA molar ratio leads to increased efficiency of PCB conjugation with thiolated BSA. Compared to native BSA, BSA–PCB conjugate binds quercetin with similar affinity but has higher antioxidant activity and increased oxidative stability.CONCLUSIONSPCB‐modified BSA could serve as a stable, food‐compatible carrier of bioactive PCB, but also bind other ligands that would be protected from oxidative damage due to the high antioxidant potential of covalently bound PCB. Thiolation by TR is, at the same time, a simple method for the covalent functionalization of virtually any protein by bioactive PCB or for obtaining PCB‐based fluorescent probes. © 2024 Society of Chemical Industry.