bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary epithelioid angiosarcoma of the mandibular gingiva: diagnostic pitfalls, about an unusual entity
Authors: El ouazzani Hafsa , Hamidi Olaya , Habimana Alain , Dani Bouchra , Boulaadas M , Zouaidia Fouad , Cherradi Nadia 
Published: May 2024

Abstract
Primary angiosarcoma of the oral cavity is a rare malignant vascular neoplasm variably recapitulating endothelial cells and is generally associated with a worse prognosis. The epithelioid subtype is even uncommon in this localization. To our knowledge, only seven cases of primary oral epithelioid angiosarcoma have been reported until 2021. This histopathological variant is characterized by solid and sheet-like growth patterns that may be misinterpreted as other lesions with epithelioid cells. Herein, we present a new case of primary epithelioid angiosarcoma of the mandibular gingiva to discuss histopathological differential diagnoses and potential diagnostic pitfalls.
Odoribacter splanchnicus bacteremia secondary to acute appendicitis: a case report with review of literature
Authors: Sasi Sreethish , Nair Arun Prabhakaran , Doiphode Sanjay , Gutti Tejeswi Shashidhar , Kolleri Jouhar , Al-Maslamani Muna 
Published: May 2024

Abstract
This report describes a rare instance of Odoribacter splanchnicus bacteremia secondary to acute appendicitis in a young man. Initially presenting with symptoms typical of appendicitis, he was diagnosed through clinical examination, laboratory tests, and computed tomography imaging, which confirmed an inflamed appendix with sealed perforation and abscess. O. splanchnicus, a Gram-negative anaerobe commonly found in the human gut, was identified as the causative agent through blood culture. The patient underwent successful laparoscopic appendectomy and was treated with intravenous amoxicillin–clavulanate, leading to a full recovery. This case highlights the potential of O. splanchnicus to act as an opportunistic pathogen in the context of intra-abdominal inflammation. It underscores the diagnostic challenges posed by O. splanchnicus, and the efficacy of advanced diagnostic tools like matrix-assisted laser desorption/ionization-time of flight mass spectrometry in identifying such rare infections.
Surgical removal of an ectopic haemodialysis catheter in the brachiocephalic artery: a case report
Authors: Adnan Isqandar , Zailani Nurul Hafizah , Varma Vimal , Mansor Mardhiah Sarah Harnani , Mokhtar Raja Amin Raja , Amir Muhammad 'Abid 
Published: May 2024

Abstract
Percutaneous central vein catheterization is commonly performed to access venous circulation for various clinical indications. However, unintentional arterial puncture may occur which can result in catastrophic complications. We report a case of an inadvertent right brachiocephalic artery cannulation in a 77-year-old lady planned for haemodialysis via a percutaneous internal jugular vein vascular access performed under ultrasound guidance. As an intravascular stent is not favourable in view of the close proximity of the right common carotid artery to the site of puncture as well as the risk of massive bleeding upon simple removal of the catheter, an open surgical removal via a median sternotomy was performed. Acquiring the competency in procedural skills, an understanding of the surgical anatomy and anticipating impending complications are of paramount importance in preventing as well as in mitigating the above complication.
An evolutionary view of the function of CC-type glutaredoxins in plant development and adaptation to the environment
Authors: El Baidouri Moaïne , Reichheld Jean-Philippe , Belin Christophe 
Published: May 2024

Abstract
Land plants have to face an oxidizing, heterogeneous, and fast changing environment. Redox-dependent post-translational modifications emerge as a critical component of plant responses to stresses. Among the thiol oxidoreductase superfamily, class III CC-type glutaredoxins (called ROXYs) are land plant specific, and their evolutionary history is highly dynamic. Angiosperms encode many isoforms, classified into five subgroups (Aα, Aβ, Bα, Bβ, Bγ) that probably evolved from five common ancestral ROXYs, with higher evolutionary dynamics in the Bγ subgroup compared with the other subgroups. ROXYs can modulate the transcriptional activity of TGA transcription factor target genes, although their biochemical function is still debated. ROXYs participate in the control of proper plant development and reproduction, and are mainly negative regulators of plant responses to biotic and abiotic stresses. This suggests that most ROXYs could play essential and conserved functions in resetting redox-dependent changes in transcriptional activity upon stress signaling to ensure the responsiveness of the system and/or avoid exaggerated responses that could lead to major defects in plant growth and reproduction. In Arabidopsis Bγ members acquired important functions in responses to nitrogen availability and endogenous status, but the rapid and independent evolution of this subclass might suggest that this function results from neofunctionalization, specifically observed in core eudicots.
Current Research on Matching Trauma-Focused Therapies to Veterans: A Scoping Review
Authors: Higgins Kristen S , Nolan Dougal , Shaheen Andrea , Rudnick Abraham 
Published: May 2024

ABSTRACT

Introduction
Trauma-focused (psycho)therapies (TFTs) are often used to treat post-traumatic stress disorder (PTSD) of (military) veterans, including prolonged exposure (PE), cognitive processing therapy (CPT), and eye movement desensitization and reprocessing. However, research thus far has not conclusively determined predictors of TFTs’ success in this population. This scoping review’s objectives are 1) to explore whether it is possible, based on currently available evidence, to match TFTs to veterans to maximize their outcomes, (2) to identify possible contraindications and adaptations of TFTs for this population, and (3) to identify gaps in the literature to guide future research.

Materials and Methods
Standard scoping review methodology was used. “White” and “gray” literature searches resulted in 4963 unique items identified. Following title and abstract screening and full-text analysis, 187 sources were included in the review. After data extraction, a narrative summary was used to identify common themes, discrepancies between sources, and knowledge gaps.

Results
Included publications most often studied CPT and PE rather than eye movement desensitization and reprocessing. These TFTs were at least partly effective with mostly moderate effect sizes. Attrition rates were slightly higher for PE versus CPT. There was variance in the methodological quality of the included studies.

Conclusion
The current literature on TFTs to treat PTSD in veterans contains several knowledge gaps, including regarding treatment matching. Future research should examine effectiveness of these treatments using multiple sources of outcomes, longer time periods, combination with other treatment, outcomes outside of PTSD symptoms (such as functioning), and resilience.
Searching for OB-type pre-supernova binary companions inside supernova remnants
Authors: Dinçel B , Uzuner M , Neuhäuser R , Pannicke A , Yerli S K , Ankay A , Mugrauer M , Torres G 
Published: May 2024

ABSTRACT
We searched for OB-runaway stars inside supernova remnants (SNRs) as a pre-supernova binary companion. As the majority of massive stars are found in close binary systems, a runaway star ejected by the orbital energy after the supernova (SN) is expected to be found. Considering a binary mass fraction, q = 0.25−1.0, the runaway star is likely to have an OB spectral type. We selected 12 SNRs at Galactic longitudes 109°−189°. Using Gaia astrometry, we selected stars having consistent distances with those of the SNRs and showing a peculiar proper motion directed away from the central region of the SNRs. We also determined the radial distribution of the extinction towards the SNRs and estimated the spectral types of the OB-runaway candidates through Gaia and Two Micron All Sky Survey photometry. We found two candidates among 12 SNRs. By spectroscopic observations, Gaia DR3 195632152560621440 inside SNR G166.0 + 4.3 was found to be an evolved A3 type star that cannot be the pre-SN binary companion to the progenitor. Gaia DR3 513927750767375872 inside SNR HB 3 is the only OB-runaway candidate (2D space velocity of 33.3 ± 3.3 km s−1). Based on photometric study, the star can be an early B-type main-sequence star with a slightly higher extinction relative to the SNR; however, it might instead be an evolved A-type star at the same distance. The other 11 SNRs do not host an OB-runaway star within their central regions. Although the runaway search was performed in a large interval of distance and extinction, we also estimated distances to the SNRs.
INSPIRE: INvestigating Stellar Population In RElics – VI. The low-mass end slope of the stellar initial mass function and chemical composition
Authors: Maksymowicz-Maciata Michalina , Spiniello Chiara , Martín-Navarro Ignacio , Ferré-Mateu Anna , Bevacqua Davide , Cappellari Michele , D’Ago Giuseppe , Tortora Crescenzo , Arnaboldi Magda , Hartke Johanna , Napolitano Nicola R , Saracco Paolo , Scognamiglio Diana 
Published: May 2024

ABSTRACT
The INSPIRE project has built the largest sample of ultra-compact massive galaxies (UCMGs) at 0.1 &lt; z &lt; 0.4 and obtained their star formation histories (SFHs). Due to their preserved very old stellar populations, relics are the perfect systems to constrain the earliest epochs of mass assembly in the Universe and the formation of massive early-type galaxies. The goal of this work is to investigate whether a correlation exists between the degree of relicness (DoR), quantifying the fraction of stellar mass formed at z &gt; 2, and the other stellar population parameters. We use the Full-Index-Fitting method to fit the INSPIRE spectra to single stellar population (SSP) models. This allows us to measure, for the first time, the slope of the IMF, as well as stellar metallicity [M/H], [Mg/Fe], [Ti/Fe], and [Na/Fe] ratios, and study correlations between them and the DoR. Similarly to normal-sized galaxies, UCMGs with larger stellar masses have overall higher metallicities. We found a correlation between the IMF slope and the DoR, that, however, breaks down for systems with a more extended SFH. An even stronger dependency is found between the IMF and the fraction of mass formed at high-z. At equal velocity dispersion and metallicity, galaxies with a higher DoR have a larger dwarf-to-giant ratio, i.e. a bottom heavy IMF, than that of low-DoR counterparts. This might indicate that the cosmic epoch and therefore different formation scenarios influence the fragmentation of the star formation cloud and hence might be the explanation for IMF variations detected in massive ETGs.
From stellar nurseries to old stellar populations: a multiwavelength case of NGC 1055
Authors: Topal Selçuk 
Published: May 2024

ABSTRACT
Given the complex nature of galaxies’ interstellar medium (ISM), multiwavelength data are required to probe the interplay among gas, dust, and stellar populations. Spiral galaxies are ideal laboratories for such a goal as they are rich in gas and dust. Using carbon monoxide (CO) along with GALEX far-ultraviolet (FUV) and Spitzer near-infrared (NIR) data we probe the correlations amongst the properties of stellar populations, gas, and dust over the disc of the spiral galaxy NGC 1055 at multiple angular resolutions, that is, 2, 4, and 17 arcsec corresponding to a linear size of 144, 288, and 1.2 kpc, respectively. Our results indicate an asymmetry in the physical conditions along the galaxy’s disc, that is, the gas is slightly more extended and brighter, and molecular gas mass is higher on the disc’s eastern side than the western side. All physical properties (i.e. molecular gas mass, CO line ratios, stellar mass, and NIR emission) decrease from the centre going outwards in the disc with some exceptions (i.e. the extinction, FUV radiation, and the [3.6]−[4.5] colour). Our analysis indicates that the colour gets bluer (metallicity increases) halfway through the disc, then redder (metallicity decreases) going outwards further in the disc.
Testing quantized inertia on Proxima Centauri
Authors: McCulloch M E 
Published: May 2024

ABSTRACT
The Alpha Centauri system has two close stars Alpha and Beta (A & B) and one much further away: Proxima Centauri. All three stars are co-moving with similar chemistry, which implies they are bound, but the fast orbit of Proxima implies it is gravitationally unbound given the visible mass of A and B. This problem cannot be fixed with the addition of dark matter, which must be uniform on such scales, or adding mass to A and B (their mass is well constrained) or by Modified Newtonian Dynamics. A new model for inertia called Quantized Inertia (QI) has been proposed that solves the galaxy rotation problem by reducing the inertia of low-acceleration stars at the galaxies’ edge in a new way, thus keeping them bound without the need for dark matter. It is shown here that if QI is applied to Proxima Centauri in the same way, it predicts the observed orbital velocity, within the bounds of observational uncertainty, and binds Proxima, without the need for extra mass.
Alternative translation initiation by ribosomal leaky scanning produces multiple isoforms of the Pif1 helicase
Authors: Lama-Diaz Tomas , Blanco Miguel G 
Published: May 2024

Abstract
In budding yeast, the integrity of both the nuclear and mitochondrial genomes relies on dual-targeted isoforms of the conserved Pif1 helicase, generated by alternative translation initiation (ATI) of PIF1 mRNA from two consecutive AUG codons flanking a mitochondrial targeting signal. Here, we demonstrate that ribosomal leaky scanning is the specific ATI mechanism that produces not only these, but also novel, previously uncharacterized Pif1 isoforms. Both in-frame, downstream AUGs as well as near-cognate start codons contribute to the generation of these alternative isoforms. This has crucial implications for the rational design of genuine separation-of-function alleles and provides an explanation for the suboptimal behaviour of the widely employed mitochondrial- (pif1-m1) and nuclear-deficient (pif1-m2) alleles, with mutations in the first or second AUG codon, respectively. We have taken advantage of this refined model to develop improved versions of these alleles, which will serve as valuable tools to elucidate novel functions of this helicase and to disambiguate previously described genetic interactions of PIF1 in the context of nuclear and mitochondrial genome stability.
Species-specific design of artificial promoters by transfer-learning based generative deep-learning model
Authors: Xia Yan , Du Xiaowen , Liu Bin , Guo Shuyuan , Huo Yi-Xin 
Published: May 2024

Abstract
Native prokaryotic promoters share common sequence patterns, but are species dependent. For understudied species with limited data, it is challenging to predict the strength of existing promoters and generate novel promoters. Here, we developed PromoGen, a collection of nucleotide language models to generate species-specific functional promoters, across dozens of species in a data and parameter efficient way. Twenty-seven species-specific models in this collection were finetuned from the pretrained model which was trained on multi-species promoters. When systematically compared with native promoters, the Escherichia coli- and Bacillus subtilis-specific artificial PromoGen-generated promoters (PGPs) were demonstrated to hold all distribution patterns of native promoters. A regression model was developed to score generated either by PromoGen or by another competitive neural network, and the overall score of PGPs is higher. Encouraged by in silico analysis, we further experimentally characterized twenty-two B. subtilis PGPs, results showed that four of tested PGPs reached the strong promoter level while all were active. Furthermore, we developed a user-friendly website to generate species-specific promoters for 27 different species by PromoGen. This work presented an efficient deep-learning strategy for de novo species-specific promoter generation even with limited datasets, providing valuable promoter toolboxes especially for the metabolic engineering of understudied microorganisms.
Health-related quality of life in surgically treated asymptomatic meningioma patients: A population-based matched cohort study
Authors: Näslund Olivia , Jakobsson Stina , Thurin Erik , Skoglund Thomas , Pettersson-Segerlind Jenny , Brynedal Boel , Jakola Asgeir S , Bartek Jiri 
Published: May 2024

Abstract

Background
Asymptomatic patients with meningiomas are increasingly detected, where management can be challenging in terms of surgery versus watchful waiting. Health-related quality of life (HRQoL) is an important factor in clinical decision-making, albeit not greatly studied in this patient group. The aim of this paper is to map the HRQoL among patients with surgically removed asymptomatic meningioma as compared to the general population.

Methods
Patients with first-time surgically treated asymptomatic meningioma between 2007 and 2013 were identified. Patients were invited in 2017 to answer a survey regarding different aspects of quality of life, using EuroQoL (EQ)-5D-3L, perceived health, lifestyle, and occupancy. Data from electronic patient records was obtained. The patients were matched based on age and gender with data from the Stockholm Region Public Health Cohort database.

Results
There was no difference in EQ-5D-3L or visual analog scale between the patients and their matched controls. Patients and controls experienced ill health to the same extent, but patients felt to a greater extent that this impacted their way of life. In 36% of patients, preoperative occupation was not resumed, mostly due to cognitive symptoms. Additionally, the study suggested social detachment in this cohort, as significantly more patients were living alone and had less emotional support compared to controls.

Conclusions
Although surgically treated patients with asymptomatic intracranial meningioma have similar overall HRQoL compared to the general population, surgery has an impact on return to work and cognitive function.
Assessing sleep in primary brain tumor patients using smart wearables and patient-reported data: Feasibility and interim analysis of an observational study
Authors: Pascoe Maeve M , Wollet Alex R , De La Cruz Minyety Julianie , Vera Elizabeth , Miller Hope , Celiku Orieta , Leeper Heather , Fernandez Kelly , Reyes Jennifer , Young Demarrius , Acquaye-Mallory Alvina , Adegbesan Kendra , Boris Lisa , Burton Eric , Chambers Claudia P , Choi Anna , Grajkowska Ewa , Kunst Tricia , Levine Jason , Panzer Marissa , Penas-Prado Marta , Pillai Valentina , Polskin Lily , Wu Jing , Gilbert Mark R , Mendoza Tito , King Amanda L , Shuboni-Mulligan Dorela , Armstrong Terri S 
Published: May 2024

Abstract

Background
Sleep–wake disturbances are common and disabling in primary brain tumor (PBT) patients but studies exploring longitudinal data are limited. This study investigates the feasibility and relationship between longitudinal patient-reported outcomes (PROs) and physiologic data collected via smart wearables.

Methods
Fifty-four PBT patients ≥ 18 years wore Fitbit smart-wearable devices for 4 weeks, which captured physiologic sleep measures (eg, total sleep time, wake after sleep onset [WASO]). They completed PROs (sleep hygiene index, PROMIS sleep-related impairment [SRI] and Sleep Disturbance [SD], Morningness-Eveningness Questionnaire [MEQ]) at baseline and 4 weeks. Smart wearable use feasibility (enrollment/attrition, data missingness), clinical characteristics, test consistency, PROs severity, and relationships between PROs and physiologic sleep measures were assessed.

Results
The majority (72%) wore their Fitbit for the entire study duration with 89% missing &lt; 3 days, no participant withdrawals, and 100% PRO completion. PROMIS SRI/SD and MEQ were all consistent/reliable (Cronbach’s alpha 0.74–0.92). Chronotype breakdown showed 39% morning, 56% intermediate, and only 6% evening types. Moderate-severe SD and SRI were reported in 13% and 17% at baseline, and with significant improvement in SD at 4 weeks (P = .014). Fitbit-recorded measures showed a correlation at week 4 between WASO and SD (r = 0.35, P = .009) but not with SRI (r = 0.24, P = .08).

Conclusions
Collecting sleep data with Fitbits is feasible, PROs are consistent/reliable, &gt; 10% of participants had SD and SRI that improved with smart wearable use, and SD was associated with WASO. The skewed chronotype distribution, risk and impact of sleep fragmentation mechanisms warrant further investigation.

Trial Registration
NCT04 669 574
Lysophosphatidylcholine binds α-synuclein and prevents its pathological aggregation
Authors: Zhao Chunyu , Tu Jia , Wang Chuchu , Liu Wenbin , Gu Jinge , Yin Yandong , Zhang Shengnan , Li Dan , Diao Jiajie , Zhu Zheng-Jiang , Liu Cong 
Published: May 2024

ABSTRACT
Accumulation of aggregated α-synuclein (α-syn) in Lewy bodies is the pathological hallmark of Parkinson's disease (PD). Genetic mutations in lipid metabolism are causative for a subset of patients with Parkinsonism. The role of α-syn's lipid interactions in its function and aggregation is recognized, yet the specific lipids involved and how lipid metabolism issues trigger α-syn aggregation and neurodegeneration remain unclear. Here, we found that α-syn shows a preference for binding to lysophospholipids (LPLs), particularly targeting lysophosphatidylcholine (LPC) without relying on electrostatic interactions. LPC is capable of maintaining α-syn in a compact conformation, significantly reducing its propensity to aggregate both in vitro and within cellular environments. Conversely, a reduction in the production of cellular LPLs is associated with an increase in α-syn accumulation. Our work underscores the critical role of LPLs in preserving the natural conformation of α-syn to inhibit improper aggregation, and establishes a potential connection between lipid metabolic dysfunction and α-syn aggregation in PD.