bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple chemical tracers finally unveil the intricate NGC 1333 IRAS 4A outflow system. FAUST XVI
Authors: Chahine Layal , Ceccarelli Cecilia , De Simone Marta , Chandler Claire J , Codella Claudio , Podio Linda , López-Sepulcre Ana , Sakai Nami , Loinard Laurent , Bouvier Mathilde , Caselli Paola , Vastel Charlotte , Bianchi Eleonora , Cuello Nicolás , Fontani Francesco , Johnstone Doug , Sabatini Giovanni , Hanawa Tomoyuki , Zhang Ziwei E , Aikawa Yuri , Busquet Gemma , Caux Emmanuel , Durán Aurore , Herbst Eric , Ménard François , Segura-Cox Dominique , Svoboda Brian , Balucani Nadia , Charnley Steven , Dulieu François , Evans Lucy , Fedele Davide , Feng Siyi , Hama Tetsuya , Hirota Tomoya , Isella Andrea , Jímenez-Serra Izaskun , Lefloch Bertrand , Maud Luke T , Maureira María José , Miotello Anna , Moellenbrock George , Nomura Hideko , Oba Yasuhiro , Ohashi Satoshi , Okoda Yuki , Oya Yoko , Pineda Jaime , Rimola Albert , Sakai Takeshi , Shirley Yancy , Testi Leonardo , Viti Serena , Watanabe Naoki , Watanabe Yoshimasa , Zhang Yichen , Yamamoto Satoshi 
Published: May 2024

ABSTRACT
The exploration of outflows in protobinary systems presents a challenging yet crucial endeavour, offering valuable insights into the dynamic interplay between protostars and their evolution. In this study, we examine the morphology and dynamics of jets and outflows within the IRAS 4A protobinary system. This analysis is based on ALMA observations of SiO(5–4), H2CO(30, 3–20, 3), and HDCO(41, 4–31, 3) with a spatial resolution of ∼150 au. Leveraging an astrochemical approach involving the use of diverse tracers beyond traditional ones has enabled the identification of novel features and a comprehensive understanding of the broader outflow dynamics. Our analysis reveals the presence of two jets in the redshifted emission, emanating from IRAS 4A1 and IRAS 4A2, respectively. Furthermore, we identify four distinct outflows in the region for the first time, with each protostar, 4A1 and 4A2, contributing to two of them. We characterize the morphology and orientation of each outflow, challenging previous suggestions of bends in their trajectories. The outflow cavities of IRAS 4A1 exhibit extensions of 10 and 13 arcsec with position angles (PA) of 0° and -12°, respectively, while those of IRAS 4A2 are more extended, spanning 18 and 25 arcsec with PAs of 29° and 26°. We propose that the misalignment of the cavities is due to a jet precession in each protostar, a notion supported by the observation that the more extended cavities of the same source exhibit lower velocities, indicating they may stem from older ejection events.
guppy i: a code for reducing the storage requirements of cosmological simulations
Authors: Mansfield Philip , Abel Tom 
Published: May 2024

ABSTRACT
As cosmological simulations have grown in size, the permanent storage requirements of their particle data have also grown. Even modest simulations present a major logistical challenge for the groups which run these boxes and researchers without access to high performance computing facilities often need to restrict their analysis to lower quality data. In this paper, we present guppy, a compression algorithm and code base tailored to reduce the sizes of dark matter-only cosmological simulations by approximately an order of magnitude. guppy is a ‘lossy’ algorithm, meaning that it injects a small amount of controlled and uncorrelated noise into particle properties. We perform extensive tests on the impact that this noise has on the internal structure of dark matter haloes, and identify conservative accuracy limits which ensure that compression has no practical impact on single-snapshot halo properties, profiles, and abundances. We also release functional prototype libraries in C, Python, and Go for reading and creating guppy data.
rAAV capsid mutants eliminate leaky expression from DNA donor template for homologous recombination
Authors: Ling Chen , Yu Chenghui , Wang Cong , Yang Ming , Yang Hengbin , Yang Keying , He Yun , Shen Yajie , Tang Shiyi , Yu Xiaomin , Zhou Zhengjun , Zhou Shaolai , Zhou Jian , Zhu Liqing , Li Jixi 
Published: May 2024

Abstract
Precise genomic editing through the combination of CRISPR/Cas systems and recombinant adeno-associated virus (rAAV)-delivered homology directed repair (HDR) donor templates represents a powerful approach. However, the challenge of effectively suppressing leaky transcription from the rAAV vector, a phenomenon associated to cytotoxicity, persists. In this study, we demonstrated substantial promoter activities of various homology arms and inverted terminal repeats (ITR). To address this issue, we identified a novel rAAV variant, Y704T, which not only yields high-vector quantities but also effectively suppresses in cis mRNA transcription driven by a robust promoter. The Y704T variant maintains normal functionality in receptor interaction, intracellular trafficking, nuclear entry, uncoating, and second-strand synthesis, while specifically exhibiting defects in transcription. Importantly, this inhibitory effect is found to be independent of ITR, promoter types, and RNA polymerases. Mechanistic studies unveiled the involvement of Valosin Containing Protein (VCP/p97) in capsid-mediated transcription repression. Remarkably, the Y704T variant delivers HDR donor templates without compromising DNA replication ability and homologous recombination efficiency. In summary, our findings enhance the understanding of capsid-regulated transcription and introduce novel avenues for the application of the rAAV-CRISPR/Cas9 system in human gene therapy.
GCMS-ID: a webserver for identifying compounds from gas chromatography mass spectrometry experiments
Authors: Wakoli Julia , Anjum Afia , Sajed Tanvir , Oler Eponine , Wang Fei , Gautam Vasuk , LeVatte Marcia , Wishart David S 
Published: May 2024

Abstract
GCMS-ID (Gas Chromatography Mass Spectrometry compound IDentifier) is a webserver designed to enable the identification of compounds from GC–MS experiments. GC–MS instruments produce both electron impact mass spectra (EI-MS) and retention index (RI) data for as few as one, to as many as hundreds of different compounds. Matching the measured EI-MS, RI or EI-MS + RI data to experimentally collected EI-MS and/or RI reference libraries allows facile compound identification. However, the number of available experimental RI and EI-MS reference spectra, especially for metabolomics or exposomics-related studies, is disappointingly small. Using machine learning to accurately predict the EI-MS spectra and/or RIs for millions of metabolomics and/or exposomics-relevant compounds could (partially) solve this spectral matching problem. This computational approach to compound identification is called in silico metabolomics. GCMS-ID brings this concept of in silico metabolomics closer to reality by intelligently integrating two of our previously published webservers: CFM-EI and RIpred. CFM-EI is an EI-MS spectral prediction webserver, and RIpred is a Kovats RI prediction webserver. We have found that GCMS-ID can accurately identify compounds from experimental RI, EI-MS or RI + EI-MS data through matching to its own large library of &gt;1 million predicted RI/EI-MS values generated for metabolomics/exposomics-relevant compounds. GCMS-ID can also predict the RI or EI-MS spectrum from a user-submitted structure or annotate a user-submitted EI-MS spectrum. GCMS-ID is freely available at https://gcms-id.ca/.
Volenrelaxin (LY3540378) increases renal plasma flow: a randomized Phase 1 trial
Authors: Tham Lai San , Heerspink Hiddo J L , Wang Xiaojun , Verdino Petra , Saifan Chadi G , Benson Eric A , Goldsmith Paul , Wang Zhenzhong , Testani Jeffrey M , Haupt Axel , Sam Flora , Cherney David Z I 
Published: May 2024

ABSTRACT

Background
Volenrelaxin is a half-life-extended recombinant human relaxin protein developed for improving kidney perfusion and cardiorenal function. This study assessed the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of volenrelaxin following single- and multiple-ascending doses (SAD and MAD) administration.

Methods
In this Phase 1, four-part, randomized, double-blinded, placebo-controlled SAD and MAD study in healthy participants, SAD participants (n = 56) received an intravenous or subcutaneous dose of volenrelaxin or placebo in a dose-ascending manner. MAD participants (n = 77) received volenrelaxin or placebo subcutaneously once weekly for 5 weeks. Effective renal plasma flow (ERPF) and measured glomerular filtration rate (mGFR) were determined by para-aminohippurate and iohexol clearance, respectively.

Results
Volenrelaxin demonstrated an extended half-life and increased acute and chronic placebo-adjusted ERPF change from baseline by 50% and 44%, respectively (P &lt; .0001). mGFR was unchanged, while filtration fraction and afferent/efferent renal arteriolar resistances were reduced. Systolic and diastolic blood pressures decreased, and pulse rate increased with increasing volenrelaxin exposures, demonstrating maximal model-derived placebo-adjusted changes (90% confidence interval) of –6.16 (–8.04, –4.28) mmHg, –6.10 (–7.61, –4.58) mmHg and +4.39 (+3.38, +5.39) bpm, respectively. Adverse events were mild, with no difference in orthostatic hypotension between volenrelaxin and placebo.

Conclusion
Volenrelaxin was well-tolerated, safe and suitable for weekly subcutaneous dosing. Volenrelaxin showed a sustained improvement in kidney perfusion upon repeated dosing, supporting further clinical development in chronic kidney disease and chronic heart failure.

Clinical trial registration
NCT04768855.
Impact of New York City Cigarette Floor Price Policy on Reducing Smoking Disparities
Authors: Ma Haijing , Golden Shelley D 
Published: May 2024

Abstract

Introduction
In 2017, New York City (NYC) passed a minimum floor price law (MFPL) to raise the minimum price of a pack of cigarettes to $13.00. Evaluation of the MFPL in NYC is limited and has yet to examine its potential as a proequity policy.

Aims and Methods
Data (n = 20 241; prepolicy n = 15 037, postpolicy n = 5204) were obtained from the New York State Adult Tobacco Survey, a quarterly repeated cross-sectional survey. Using the Difference-in-Differences approach, we compared changes in reported cigarette prices, cigarette consumption, and smoking status among NYC residents before and after policy implementation to changes in the same outcomes among residents in the rest of the state (ROS) over the same period.

Results
For some smokers, cigarette price increased in NYC for the postpolicy period; moreover, prices increased more in NYC than in ROS. NYC smokers who reported higher income, more education, or White or “Other” race, reported a bigger price increase than their ROS counterparts. Cigarette consumption decreased more in the postpolicy period for people in the ROS, in general and among certain groups. Everyday smoking status decreased similarly in both NYC and ROS, whereas someday smoking status decreased primarily in the ROS during the analysis period.

Conclusions
Cigarette prices in NYC increased after the 2017 MFPL; these increases were greater than those occurring elsewhere in the state, suggesting the policy might be a factor in the change. However, the increases were concentrated among relatively higher-priced purchases, and groups with lower smoking prevalence. Changes in smoking status and cigarette consumption did not correspond to study hypotheses.

Implications
This study provides an empirical analysis of a real-world policy in tobacco control. It examines the potential of the MFPL in NYC as a proequity policy. Findings extend the current MFPL literature and suggest that they may be able to raise cigarette prices for some purchases, but also may have a limited impact on smoking behaviors.
Inflation-overshooting commitment: an analysis using a macroeconomic model
Authors: Kawamoto Takuji , Nakajima Jouchi , Mikami Tomoaki 
Published: May 2024

Abstract
This article examines the effectiveness of the makeup strategy for Japan’s economy, where inflation expectations formation is known to be largely adaptive. We build a small-scale macroeconomic model and conduct simulation analysis to study the implications of adopting the makeup strategy for early achievement of the inflation target and the incurring costs. Simulation results show that when the inflation rate has been below the target, it is effective to stabilize average inflation by offsetting the past inflation misses over some makeup windows and that when the natural rate of interest is lower, the optimal makeup window becomes longer.
Unleashing patient voices: empowering adverse event assessment with complete patient-reported outcomes
Authors: Phung Thi Hanh , Bradford Natalie , Pitt Erin , Alexander Kimberly 
Published: May 2024

Abstract
The 124-item patient reported-outcome common terminology criteria for adverse events (PRO-CTCAE) questionnaire, assessing 78 symptoms, is widely used in cancer clinical trials to identify side effects. However, its regular use in routine cancer care is rarely reported. We aimed to investigate the feasibility of weekly PRO-CTCAE completion over 9 weeks in a prospective study with 30 patients with cancer undergoing chemotherapy. Participants were asked to complete electronic surveys with reminders, but no feedback or incentives. Only 136 (50%) of the planned 270 time points at which a PRO-CTCAE self-report was expected were completed, with an additional 21 (8%) partially completed, and represents a failure to achieve the expected level of completion. Patients reported experiencing up to 51 and a median of 30 symptoms across all time points, highlighting the complexity of symptom assessment in acute cancer care. While weekly implementation of the PRO-CTCAE may not be feasible outside of clinical trial settings, this study highlights the breadth of symptoms experienced.
Frequency of HLA-A*02:01 in the Brazilian population and its impact on uveal melanoma systemic treatment
Authors: de Melo Andreia Cristina , Lucena Evandro , de Oliveira Danielli Cristina Muniz , Viola João P B 
Published: May 2024

Abstract
Uveal melanoma is a rare malignancy originating from extracutaneous melanocytes on the uveal layer of the eyes. The incidence varies depending on the ethnic and racial global distribution, as uveal melanoma is more frequently diagnosed in non-Hispanic White subjects when compared with Hispanic, Asian, or Black individuals. Despite all the local effective management of uveal melanoma, roughly 50% of the cases will develop distant metastases. For these cases, the historical median overall survival is around 12 months. Recently, tebentafusp became the first therapy to receive Food and Drug Administration approval following a phase 3 trial demonstrating a continued long-term benefit for overall survival among adult HLA-A*02:01-positive patients with previously untreated metastatic uveal melanoma. Since 2021, high-resolution sequence-based HLA typing has been considered the gold standard for determining HLA alleles and haplotypes for the Brazilian Bone Marrow Donor Registry (REDOME) donors. To depict the HLA-A*02:01-positivity in Brazilian individuals, the REDOME database was queried out for the donors included from 2021 to 2023 and tested for HLA in high-resolution platforms. A total of 203, 44 donors were included and the frequency of the HLA-A*02:01 was 21.01%, much lower compared to the frequency in North Americans and Europeans (around 45%). Despite tebentafusp has demonstrated promising results in the treatment of uveal melanoma, the number of patients to benefit from this new approach can strongly vary by ethnic and racial issues. New strategies for the systemic treatment of advanced uveal melanoma have to be developed and tested as this disease still represents an unmet medical need.
Verbal disputes about the content of experience
Authors: Speaks Jeff 
Published: May 2024

Abstract
A verbal dispute is one in which the disputants agree on all of the facts about the intended subject matter of the dispute and disagree only about how to use certain terms. This paper explores the possibility that the dispute between particularists and generalists about the contents of perceptual experience is a verbal dispute. The aim is less to provide a knockdown argument for the conclusion that this dispute is merely verbal than to show how difficult it is to uncover a substantive dispute between the two sides. A concluding section asks whether the argument generalizes beyond the particularism/generalism dispute to other prominent disputes in contemporary philosophy of mind.
Information Spillovers and Sovereign Debt: Theory Meets the Eurozone Crisis
Authors: Cole Harold L , Neuhann Daniel , Ordoñez Guillermo 
Published: May 2024

Abstract
We develop a theory of information spillovers in sovereign bond markets in which investors can learn about default risk before trading in primary and secondary markets. If primary markets are structured as multi-unit discriminatory-price auctions, an endogenous winner’s curse leads to strategic complementarities in information acquisition. Shocks to default risk in one country may trigger crisis episodes with widespread information acquisition, sharp increases in the level and volatility of yields in risky countries, low and stable yields in safe countries, market segmentation, and arbitrage profits between primary and secondary markets. These predictions are consistent with the dynamics of auction informativeness during the Eurozone Sovereign Debt Crisis, which we measure using the reaction of secondary market yields to primary market yields.
Does Pricing Carbon Mitigate Climate Change? Firm-Level Evidence from the European Union Emissions Trading System
Authors: Colmer Jonathan , Martin Ralf , Muûls Mirabelle , Wagner Ulrich J 
Published: May 2024

Abstract
In theory, market-based regulatory instruments correct market failures at least cost. However, evidence on their efficacy remains scarce. Using administrative data, we estimate that, on average, the European Union Emissions Trading System (EU ETS)—the world’s first and largest market-based climate policy—induced regulated manufacturing firms to reduce carbon dioxide emissions by 14–16% with no detectable contractions in economic activity. We find no evidence of outsourcing to unregulated firms or markets; instead, firms made targeted investments, reducing the emissions intensity of production. These results indicate that the EU ETS induced global emissions reductions, a necessary and sufficient condition for mitigating climate change. We show that the absence of any negative economic effects can be rationalized in a model where pricing the externality induces firms to make fixed-cost investments in energy-saving capital that reduce marginal variable costs.
The Dynamics of Loan Sales and Lender Incentives
Authors: Gryglewicz Sebastian , Mayer Simon , Morellec Erwan 
Published: May 2024

Abstract
How much of a loan should a lender retain, and how do loan sales affect loan performance? We address these questions in a model in which a lender originates loans that it can sell to investors. The lender reduces default risk through screening at origination and monitoring after origination, but is subject to moral hazard. The optimal lender-investor contract can be implemented by requiring the lender to initially retain a share of the loan that it gradually sells to investors, rationalizing loan sales after origination. The model generates novel predictions linking loan and lender characteristics to initial retention, sales dynamics, and loan performance.
Ramosetron as an add-on therapy for refractory fibromyalgia: a randomized, double-blind, placebo-controlled trial
Authors: Park Dong-Jin , Jeong Hyemin , Choi Sung-Eun , Kang Ji-Hyoun , Lee Jung-Kil , Lee Shin-Seok 
Published: May 2024

Abstract

Objective
This study aimed to assess the efficacy and safety of intravenous ramosetron for pain relief in patients with fibromyalgia (FM) unresponsive to conventional treatments.

Methods
In this prospective, double-blind, placebo-controlled trial, 80 FM patients were randomly allocated to receive either placebo (n = 40) or ramosetron (n = 40) at a dosage of 0.3 mg/day intravenously for five consecutive days. The primary outcome was the reduction in pain intensity at the end of the treatment period, evaluated using a visual analogue scale (VAS). Secondary outcome measures included the FM Impact Questionnaire, Beck Depression Inventory (BDI), Multi-Dimensional Health Assessment Questionnaire (MDHAQ), EQ-5D and State-Trait Anxiety Inventory on days 5 (end of treatment), 7, 10 and 28. Safety was continuously monitored throughout the study.

Results
At the end of the treatment phase, the ramosetron group demonstrated a significantly greater reduction in VAS pain scores compared with the placebo group (1.18 ± 1.60 vs 0.54 ± 1.59, P &lt; 0.05). Additionally, the ramosetron group exhibited significant improvements in BDI (4.42 ± 5.18 vs 1.33 ± 4.87, P &lt; 0.05) and MDHAQ pain scale (0.37 ± 0.74 vs 0.04 ± 0.52, P &lt; 0.05) scores. However, these improvements in pain VAS and BDI scores were not sustained through day 28. The safety profile of ramosetron was favorable, with gastrointestinal symptoms, particularly constipation, being the most commonly reported adverse events.

Conclusions
Intravenous administration of ramosetron provided safe and effective short-term relief of pain intensity in FM patients with inadequate response to standard treatments.
The Role of Social Deprivation and Cannabis Use in Explaining Variation in the Incidence of Psychotic Disorders: Findings From the EU-GEI Study
Authors: Brink Vera , Andleeb Humma , Gayer-Anderson Charlotte , Arango Celso , Arrojo Manuel , Berardi Domenico , Bernardo Miquel , Bobes Julio , Del-Ben Cristina Marta , Ferraro Laura , de Haan Lieuwe , La Barbera Daniele , La Cascia Caterina , Lasalvia Antonio , Llorca Pierre-Michel , Menezes Paolo Rossi , Pignon Baptiste , Sanjuán Julio , Santos José Luis , Selten Jean-Paul , Tarricone Ilaria , Tortelli Andrea , Tripoli Giada , Velthorst Eva , Rutten Bart P F , van Os Jim , Quattrone Diego , Murray Robin M , Jones Peter B , Morgan Craig , Di Forti Marta , Jongsma Hannah E , Kirkbride James B 
Published: May 2024

Abstract

Background and Hypothesis
Recent findings suggest the incidence of first-episode psychotic disorders (FEP) varies according to setting-level deprivation and cannabis use, but these factors have not been investigated together. We hypothesized deprivation would be more strongly associated with variation in FEP incidence than the prevalence of daily or high-potency cannabis use between settings.

Study Design
We used incidence data in people aged 18–64 years from 14 settings of the EU-GEI study. We estimated the prevalence of daily and high-potency cannabis use in controls as a proxy for usage in the population at-risk; multiple imputations by chained equations and poststratification weighting handled missing data and control representativeness, respectively. We modeled FEP incidence in random intercepts negative binomial regression models to investigate associations with the prevalence of cannabis use in controls, unemployment, and owner-occupancy in each setting, controlling for population density, age, sex, and migrant/ethnic group.

Study Results
Lower owner-occupancy was independently associated with increased FEP (adjusted incidence rate ratio [aIRR]: 0.76, 95% CI: 0.61–0.95) and non-affective psychosis incidence (aIRR: 0.68, 95% CI: 0.55–0.83), after multivariable adjustment. Prevalence of daily cannabis use in controls was associated with the incidence of affective psychoses (aIRR: 1.53, 95% CI: 1.02–2.31). We found no association between FEP incidence and unemployment or high-potency cannabis use prevalence. Sensitivity analyses supported these findings.

Conclusions
Lower setting-level owner-occupancy and increased prevalence of daily cannabis use in controls independently contributed to setting-level variance in the incidence of different psychotic disorders. Public health interventions that reduce exposure to these harmful environmental factors could lower the population-level burden of psychotic disorders.