bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Pyrazolyl‐Indolizine Derivatives as Antimicrobial Agents: Synthesis, In vitro, In silico ADMET and Molecular Docking Studies
Authors: Mukhtar Shorouk S. , Sroor Farid M. , Hafez Taghrid S. , Abdelraof Mohamed , El‐Sayed Ahmed F. , Laboud Yara N. , Hassaneen Hamdi M. , Saleh Fatma M. 
Published: May 2024

AbstractHerein, we report analogues of s‐indacene by the synthesis of novel indolizine derivatives. Using chloroform as an appropriate solvent, sixteen derivatives of pyrazolyl‐indolizine (4‐‐19) were prepared by the reaction of 3‐(dimethylamino)‐1‐(1H‐pyrrol‐2‐yl)prop‐2‐en‐1‐one (1) with hydrazonoyl chloride derivatives (2) in the presence of triethylamine in good to excellent yields. We used NMR spectra, IR, mass spectrometry, as well as elemental analyses to prove the chemical structures and the purity of the synthesized compounds 4–19. Among all tested compounds 5, 9, 13 and 19 had a potent antimicrobial efficiency against Bacillus subtilis, Staphylococcus aureus, Pseudomonas aerginousea, Sallmonella typhemerium, and Candida albicans. Furthermore, a significant increase in lipid peroxidation (LPO) toward the Gram‐negative bacteria, Pseudomonas aeruginosa when treated with compound 9 was observed, while compound 13 remarkably increased the cell membrane oxidation of Salmonella typhimurium. Additionally, we utilized docking studies and in silico methods to evaluate the drug‐likeness, physicochemical properties, and ADMET profiles of the compounds. The results of the molecular docking simulation revealed that the synthesized compounds displayed decreased binding energy when interacting with the active sites of important enzymes, including Sterol 14‐demethylase of C. albicans, Dihydropteroate synthase of S. aureus, LasR of P. aeruginosa, Glucosamine‐6‐phosphate synthase of S. typhimurium, and Gyrase B of B. subtilis.
Long COVID‐19 leading to Good's syndrome diagnosis: A clinical case‐report and literature review
Authors: Tabarsi Payam , Hemmatian Marjan , Moradi Maryam 
Published: May 2024

Key Clinical MessageGood's syndrome (GS) in conjunction with a severe COVID‐19 infection, shedding light on the complexities of managing this rare condition that combines thymoma and immunodeficiency.AbstractThis study delves into the clinical presentation and management of a 63‐year‐old male diagnosed with Good's syndrome (GS) amid a severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. GS, an uncommon association between thymoma and immunodeficiency, remains a clinical mystery, necessitating increased awareness and understanding. Our patient's intricate clinical course, marked by recurrent COVID‐19 symptoms and multiple hospitalizations, exemplifies the challenges posed by GS. Through a systematic review of GS cases globally, we highlight its worldwide distribution, with a substantial proportion reported in Europe. Notably, the diagnosis of thymoma often precedes immunodeficiency, emphasizing the importance of vigilance in clinical assessments.
A 7‐year‐old with extravaginal torsion of an undescended testicle in the left inguinal region: The first case report from Syria
Authors: Alsaffaf Yousef , Arab Hazem , Jaafar Jaafar , Shehadeh Mohammad 
Published: May 2024

Key Clinical MessageThe incidence of undescended testicles torsion in a 7‐year‐old is rare, making it a clinically unusual occurrence. Emphasizing the importance of thorough urogenital assessments in children, particularly in underserved communities, is critical to prevent serious complications like testicular gangrene.
Iron deficiency in new onset heart failure: association with clinical factors and quality of life
Authors: Cabrera Carin Corovic , Ekström Mattias , Tornvall Per , Löfström Ulrika , Frisk Christoffer , Linde Cecilia , Hage Camilla , Persson Hans , Eriksson Maria J. , Wallén Håkan , Persson Bengt , Lyngå Patrik 
Published: May 2024

AbstractAimsThe prevalence of iron deficiency (ID) in newly diagnosed heart failure (HF) and the progression of ID in patients after initiation of HF therapy are unknown. We aimed to describe the natural trajectory of ID in patients with new onset HF during the first year after HF diagnosis, assessing associations between ID, clinical factors, and quality of life (QoL).Methods and resultsA prospective cohort of patients with new onset HF in hospitals or outpatient clinics at five major hospitals in Stockholm, Sweden, during 2015–2018 were analysed with clinical assessment, electrocardiogram, blood samples including iron levels, Minnesota living with heart failure questionnaire (MLHFQ), and echocardiogram at baseline and after 12 months. Of 547 patients with new‐onset HF, 482 (88%) had complete iron data at baseline. Median age was 70 years (interquartile range 61–77) and 311 (65%) were men; 55% of patients had ejection fraction (EF) ≤ 40%, 19% had EF 41–49%, and 26% had HF with preserved EF (HFpEF) [Correction added on 26 June 2024, after first online publication: The ‘Mean age was 70 years’ has been corrected to ‘Median age was 70 years’ in this version.]. At baseline, 163 patients (34%) had ID defined as ferritin <100 μg/L or ferritin 100–299 μg/L and transferrin saturation <20%. After 12 months of follow‐up, 119 (32%) had ID of the 368 patients who had complete iron data both at baseline and after 12 months and did not receive intravenous (i.v.) iron during follow‐up. During the first year after HF diagnosis, 19% had persistent ID, 13% developed ID, 11% resolved ID, and 57% never had ID, consequently 24% changed their classification. Anaemia at baseline was the strongest independent predictor of ID 1 year after diagnosis [odds ratio (OR) 3.91, 95% confidence interval (CI) 1.88–8.13, P < 0.001], followed by HF hospitalization (OR 2.21, 95% CI 1.24–3.95, P < 0.01), female sex (OR 2.04, 95% CI 1.25–3.32, P < 0.01), HFpEF (OR 1.96, 95% CI 1.13–3.39, P < 0.05), and diabetes mellitus (OR 1.92, 95% CI 1.06–3.48, P < 0.05). ID was associated with low QoL at baseline (MLHFQ score mean difference 7.4 points, 95% CI 3.1–11.7, P < 0.001), but not at follow‐up.ConclusionsAbout one third of patients with new onset HF had ID both at the time of HF diagnosis and after 1 year, though a quarter of the patients changed their ID status. Patients with anaemia, HF hospitalization, female gender, HFpEF, or diabetes mellitus at baseline were more likely to have ID after 1 year implying that these should be carefully screened for ID to find those in need of i.v. iron treatment.
Ni2MnAl Heusler Alloy Nanoparticles for Chemoselective Hydrogenation of Nitro Compounds
Authors: Gupta Poorvi , Yadav Priyanka , Rana Bharti , Ghosh Biplab , Dhaka Rajendra S. , Manna Kuntal 
Published: May 2024

AbstractDespite immense interest for years in Heusler alloys as magnetoelastic materials, their application in heterogeneous catalysis has only recently been explored. We report the development of highly active, robust and magnetically separable Ni2MnAl Heusler alloy nanoparticles as a heterogeneous catalyst for hydrogenation of aliphatic and aromatic nitro compounds to the corresponding amines. The easily synthesizable Ni2MnAl nanoparticles are thermally and chemically robust and exhibited excellent chemoselectivity in the hydrogenation of a range of aliphatic and aromatic nitroarenes, including those bearing functional groups sensitive to reduction, such as alkene, bromo, iodo, carbonyl and cyano, yielding the respective functionalized amines in good yields. Moreover, this solid catalyst is magnetically separable from the reaction mixture and could be recycled and reused at least 10 times without any loss in catalytic activity. The mechanism of the Ni2MnAl Heusler alloy nanoparticles catalyzed nitro reduction was studied by various spectroscopy, control experiments and kinetics. Our work opens a new avenue of developing heterogeneous earth‐abundant metal catalysis for economic and environment‐friendly synthesis of fine chemicals owing to straightforward synthesis and tunable composition of Heusler alloy nanoparticles from base‐metal precursors and their diverse structure and properties in conjunction with their thermal and chemical stability, excellent chemoselectivity, magnetic separability and recyclability.
Effect of storage on the physicochemical, rheological, antioxidant activity, and sensory properties of soy whey‐fortified pineapple juice beverages
Authors: Rather Jahangir A. , Punoo Hilal Ahmad , Akhter Najmeenah , Muzzaffar Sabeera , Khanday Firdous Ahmad , Goksen Gulden 
Published: May 2024

AbstractIncorporating soy whey into pineapple juice can enhance nutritional and nutraceutical potential. The present study was conducted to develop soy whey‐fortified pineapple juice beverage and impact of ambient storage conditions on physicochemical, antioxidant, rheological, and sensory properties of functional beverage. Increasing the storage period decreased pH from 4.1 to 3.7 for control and 4.0 to 3.8 for soy whey‐treated samples. TSS increased from 8.3 to 10.6 on 0th day for control and soy whey‐treated beverage samples while on the 30th day, the TSS ranged from 8.9 to 11.1°B. Up to 30% soy whey incorporation, the DPPH, reducing power, and ABTS of beverages increased from 5.58%–57.01%, 56.35%–56.90%, and 4.84%–47.01%, respectively. The flow index (n) of the beverage formulations ranged between 0.4758 and 0.6521, and the yield stress between 0.018 and 0.025 Pa, hence showing Herschel–Bulkley character. With the increase in concentration and storage period, both G′ and G″ values decreased considerably (p < .05). The standard plate and yeast and mold count decreased considerably with an increase in soy whey and increased with an increase in storage. The sensory score of the beverages up to 30% soy whey exhibited best sensory score results compared to control and samples with 30% above soy whey content.
Recent progress in heterostructured materials for room‐temperature sodium‐sulfur batteries
Authors: Song Haobin , Li Yifan , Li Xue L. , Li Yixiang , Li Dong‐sheng , Wang Deli , Huang Shaozhuan , Yang Hui Ying 
Published: May 2024

AbstractRoom‐temperature sodium‐sulfur (RT Na‐S) batteries are a promising next‐generation energy storage device due to their low cost, high energy density (1274 Wh kg−1), and environmental friendliness. However, RT Na‐S batteries face a series of vital challenges from sulfur cathode and sodium anode: (i) sluggish reaction kinetics of S and Na2S/Na2S2; (ii) severe shuttle effect from the dissolved intermediate sodium polysulfides (NaPSs); (iii) huge volume expansion induced by the change from S to Na2S; (iv) continuous growth of sodium metal dendrites, leading to short‐circuiting of the battery; (v) huge volume expansion/contraction of sodium anode upon sodium plating/stripping, causing uncontrollable solid‐state electrolyte interphase growth and “dead sodium” formation. Various strategies have been proposed to address these issues, including physical/chemical adsorption of NaPSs, catalysts to facilitate the rapid conversion of NaPSs, high‐conductive materials to promote ion/electron transfer, good sodiophilic Na anode hetero‐interface homogenized Na ions flux and three‐dimensional porous anode host to buffer the volume expansion of sodium. Heterostructure materials can combine these merits into one material to realize multifunctionality. Herein, the recent development of heterostructure as the host for sulfur cathode and Na anode has been reviewed. First of all, the electrochemical mechanisms of sulfur cathode/sodium anode and principles of heterostructures reinforced Na‐S batteries are described. Then, the application of heterostructures in Na‐S batteries is comprehensively examined. Finally, the current primary avenues of employing heterostructures in Na‐S batteries are summarized. Opinions and prospects are put forward regarding the existing problems in current research, aiming to inspire the design of advanced and improved next‐generation Na‐S batteries.
The role of market discipline and macroprudential policies in achieving bank stability
Authors: Matos Tiago F. A. , Teixeira João C. A. , Dutra Tiago M. 
Published: May 2024

AbstractThis study examines whether forcing banks to hold subordinated debt and enforcing market discipline could enhance the effectiveness of capital macroprudential policies in reducing banks' risk and contribute to bank stability. Using the system generalised method of moments and based on a sample of 322 banks across 18 countries during the period 2006–2020, we find that a higher level of subordinated debt leads banks to avoid moral‐hazard behaviours and engage in risk shifting when adapting to a tighter macroprudential framework, which in turn leads to a greater effectiveness of these policies. Furthermore, as robustness tests, we show that this effect is stronger in advanced economies and in the United States of America. These results also stand using a different proxy for banks' risk.
Enhanced luminescence using the core‐shell‐shell structure of 3‐mercaptopropionic acid‐capped ZnSe/ZnS: Mn/ZnS quantum dot
Authors: Bui Thi‐Diem , Nguyen Quang‐Liem , Luong Thi‐Bich , Van Cuong Nguyen , Dang Phuc Huu 
Published: May 2024

AbstractIn this study, we used the surface stabilizer 3‐mercaptopropionic acid (MPA) to synthesize ZnSe quantum dots in nontoxic aqueous solvents. Because of the –COOH group, MPA is an SH‐R‐COOH molecule that is added to improve the dispersion and quantum dot (QD) compatibility with antibodies. The different structures ZnSe, Mn‐doped ZnSe, Mn‐doped ZnSe/ZnS, and ZnSe/Mn‐doped ZnS/ZnS were investigated to find the optimum photoluminescence (PL). The structure and distribution element of ZnSe/Mn‐doped ZnS/ZnS QD were analyzed by the high‐resolution TEM image and scanning transmission electron microscopy. This finding of the ZnS buffer layer helps to reduce the defect lattice of QDs, which increases PL significantly. The highest PL intensity of ZnSe/ZnS:Mn/ZnS is significantly more than that of ZnSe and ZnSe/ZnS 6.2 and 3.3 times, respectively. In addition, the fluorescence efficiency of ZnSe/ZnS:5%Mn/ZnS‐MPA was 74.37% higher than that of ZnSe:5%Mn/ZnS‐MPA (55.04%) in ZnS buffer.
Sigmoid Sinus Wall Anomalies Can Progress and May Not Be Congenital
Authors: Hsieh Yue‐Lin , Wang Wuqing 
Published: May 2024

ObjectiveSigmoid sinus wall anomalies (SSWA) are closely linked to venous pulsatile tinnitus (PT). This study aims to demonstrate that SSWA develops progressively rather than being congenital.MethodsWe retrospectively analyzed 42 PT patients with SSWA who had at least two non‐operative CT scans at our clinic. CT images were longitudinally assessed to track SSWA progression, while MRI and Doppler ultrasound evaluated transverse sinus stenosis and venous hemodynamics. Changes in PT perception were tracked using the tinnitus handicap inventory (THI) questionnaire.ResultsAmong the 42 SSWA patients, 12 (28.6%) exhibited progression. Anastomosis between diploic vein and diverticulum was significantly higher compared to the dehiscence cohort (p < 0.01). Within the diverticulum group, seven individuals (30.4%) experienced enlargement, with a mean diverticular wall expansion of 5.9% ± 11.4%. Progressive erosion was observed in two cases (12.5%) in the dehiscence cohort, with a mean sigmoid plate erosion of 3.8% ± 10.1%. In cases progressing from dehiscence to diverticulum, three subjects transitioned, with a mean sigmoid sinus wall length expansion of 43.8% ± 31.9%. SSWA progression showed a significant negative correlation with QBILATERAL (r = −0.857, p = 0.014), and there was a significant difference between initial and revisit THI scores (p < 0.01).ConclusionSSWA can undergo morphological progression, indicating it is a progressive clinical condition rather than congenital.Level of Evidence4 Laryngoscope, 134:4707–4715, 2024
Jet‐injection assisted photodynamic therapy for superficial and nodular basal cell carcinoma: A pilot study
Authors: Lavin Leore , Erlendsson Andrés M. , Aleissa Saud , Aleisa Abdullah , Menzer Christian , Dusza Stephen , Cordova Miguel , Alshaikh Hesham , Shah Rohan , Pan Alexander , Ketosugbo Kwami , Hosein Sharif , Lee Erica , Nehal Kishwer , Togsverd‐Bo Katrine , Haedersdal Merete , Rossi Anthony 
Published: May 2024

AbstractBackgroundPhotodynamic therapy (PDT) with topical δ‐Aminolevulinic acid (ALA) has efficacy in treating basal cell carcinoma (BCC) but is limited by incomplete penetration of ALA into the deeper dermis. This prospective open‐label pilot trial investigated the safety and efficacy of photosensitizer jet injection for PDT (JI‐PDT) for BCC treatment. It was performed with 15 patients (n = 15) with histologically confirmed, untreated, low‐risk nodular BCCs at a single institution.MethodsFor the intervention, JI‐PDT patients (n = 11) received two sessions of jet‐injected ALA with PDT separated by four to 6 weeks. To further understand treatment technique, another group of patients (n = 4) received jet‐injected ALA followed by tumor excision and fluorescence microscopy (JI‐E). Treatment tolerability was assessed by local skin responses (LSR) score at five distinct time intervals. Fluorescence microscopy assessed protoporphyrin IX penetration depth and biodistribution within the tumor. At the primary endpoint, tumor clearance was evaluated via visual inspection, dermoscopy and reflectance confocal microscopy. Postinjection and postillumination pain levels, and patient satisfaction, were scored on a 0−10 scale.ResultsFifteen participants with mean age of 58.3, who were 15/15 White, non‐Hispanic enrolled. The median composite LSR score immediately after JI‐PDT was 5 (interquartile range [IQR] = 3) which decreased to 0.5 (IQR = 1) at primary endpoint (p < 0.01). Immunofluorescence of excised BCC tumors with jet‐injected ALA showed photosensitizer penetration into papillary and reticular dermis. Of the 13 JI‐PDT tumors, 11 had tumor clearance confirmed, 1 recurred, and 1 was lost to follow‐up. 1/11 patients experienced a serious adverse event of cellulitis. 70% of patients had local scarring at 3 months. Patients reported an average pain level of 5.6 (standard deviation [SD] = 2.3) during jet injection and 3.7 (SD = 1.8) during light illumination.ConclusionsJet injection of ALA for PDT treatment of nodular low‐risk BCC is tolerable and feasible and may represent a novel modality to improve PDT.
Aqueous Supramolecular Transformations of Motor Bola‐Amphiphiles at Multiple Length‐Scale
Authors: Meng Jiahui , Cheung Leong‐Hung , Ren Yikun , Stuart Marc C. A. , Wang Qian , Chen Shaoyu , Chen Jiawen , Leung Franco King‐Chi 
Published: May 2024

AbstractMolecular motor amphiphiles have already been widely attempted for dynamic nanosystems across multiple length‐scale for developments of small functional materials, including controlling macroscopic foam properties, amplifying motion as artificial molecular muscles, and serving as extracellular matrix mimicking cell scaffolds. However, limiting examples of bola‐type molecular motor amphiphiles are considered for constructing macroscopic biomaterials. Herein, this work presents the designed two second generation molecular motor amphiphiles, motor bola‐amphiphiles (MBAs). Aside from the photoinduced motor rotation of MBAs achieved in both organic and aqueous media, the rate of recovering thermal helix inversion step can be controlled by the rotor part with different steric hindrances. Dynamic assembled structures of MBAs are observed under (cryo)‐transmission electron microscopy (TEM). This dynamicity assists MBAs in further assembling as macroscopic soft scaffolds by applying a shear‐flow method. Upon photoirradiation, the phototropic bending function of MBA scaffolds is observed, demonstrating the amplification of molecular motion into macroscopic phototropic bending functions at the macroscopic length‐scale. Since MBAs are confirmed with low cytotoxicity, human bone marrow‐derived mesenchymal stem cells (hBM‐MSCs) can grow on the surface of MBA scaffolds. These results clearly demonstrate the concept of designing MBAs for developing photoresponsive dynamic functional materials to create new‐generation soft robotic systems and cell‐material interfaces.
Liquid biopsy for human cancer: cancer screening, monitoring, and treatment
Authors: Wang Hao , Zhang Yi , Zhang Hao , Cao Hui , Mao Jinning , Chen Xinxin , Wang Liangchi , Zhang Nan , Luo Peng , Xue Ji , Qi Xiaoya , Dong Xiancheng , Liu Guodong , Cheng Quan 
Published: May 2024

AbstractCurrently, tumor treatment modalities such as immunotherapy and targeted therapy have more stringent requirements for obtaining tumor growth information and require more accurate and easy‐to‐operate tumor information detection methods. Compared with traditional tissue biopsy, liquid biopsy is a novel, minimally invasive, real‐time detection tool for detecting information directly or indirectly released by tumors in human body fluids, which is more suitable for the requirements of new tumor treatment modalities. Liquid biopsy has not been widely used in clinical practice, and there are fewer reviews of related clinical applications. This review summarizes the clinical applications of liquid biopsy components (e.g., circulating tumor cells, circulating tumor DNA, extracellular vesicles, etc.) in tumorigenesis and progression. This includes the development process and detection techniques of liquid biopsies, early screening of tumors, tumor growth detection, and guiding therapeutic strategies (liquid biopsy‐based personalized medicine and prediction of treatment response). Finally, the current challenges and future directions for clinical applications of liquid biopsy are proposed. In sum, this review will inspire more researchers to use liquid biopsy technology to promote the realization of individualized therapy, improve the efficacy of tumor therapy, and provide better therapeutic options for tumor patients.
Effect of polymer crosslinking to the failure behavior of thermoplastic composite remelting interface: Molecular dynamics simulation and experimental verification
Authors: Dai Guangming , Zhan Lihua , Zhu Jingguo , Huang Minghui , Zhang Dechao 
Published: May 2024

AbstractThe forming interface is the weak link of thermoplastic composite complex structures. To explore the effect of polymer crosslinking on the failure behavior of thermoplastic composite remelting interface using “Preforming + Remelting bonding” process, the all‐atom models of different types of interfaces were established, and a molecular dynamics (MD) simulation was conducted on the uniaxial tensile failure process of the remelting interface. The failure behavior of the remelting interface with different preforming processes was tested to verify the correctness of MD simulation, and the influencing mechanism of polymer crosslinking reactions in the preforming stage to the remelting interface properties was clarified. The results showed that the yield stress of the uncrosslinked interface reaches 283.2 MPa and 16.0% and 50.6% higher than that of the unilateral and bilateral crosslinked interfaces respectively. The polymer crosslinking reaction during the preforming stage will reduce the interlaminar bonding performance. The interlaminar shear strength (ILSS) of the uncrosslinked interface is 87.46 MPa and 7.21% and 27.36% higher than that of the unilateral and bilateral crosslinked interface respectively, and only 3.95% lower than that of the non‐remelting sample formed by standard process. This research provides a new approach for predicting and analyzing the effect of polymer crosslinking on remelting interface properties of thermoplastic composite using “Preforming + Remelting bonding” process.Highlights
The failure behavior of different thermoplastic composite remelting interfaces was studied.
MD simulation was conducted on the uniaxial tensile failure process of the remelting interface.
The influencing mechanism of polymer crosslinking reactions in the preforming stage to the remelting interface properties was clarified.
It is effective to explore the failure mechanism of thermoplastic remelting interface by MD simulation.