bluuebunny/crossref_metadata_2025_split huggingface dataset:
Augmenting effect of sizofiran on the bmmunofunction of regional lymph nodes in cervical cancer
Authors: Shimizu Yoshio , Hasumi Katsuhiko , Masubuchi Kazumasa 
Published: August 2010

AbstractThe immunomodulating effect of sizofiran on regional lymph nodes (RLN) was studied in cervical cancer and benign gynecologic tumors comparatively between treated patients (sizofiran intramuscularly (1) 1 day (20 mg) before and (2) 8 days (20 mg) and 1 day (20 mg) before surgery; n = 34) and untreated patients (n = 21). The RLN (internal iliac lymph nodes) were dissected surgically, and freshly obtained mononuclear (MN) cells were studied to observe interleukin‐2 (IL‐2) production and lymphokine‐activated killer cell and natural‐killer cell activities. The infiltration of surface phenotype of MN cells into RLN was determined semiquantitatively by immunohistochemistry. Sizofiran augmented IL‐2 production of RLN, which was accompanied by a marked increase in the number of cells stained with anti‐Leu‐3a and IL‐2 receptor. This effect was found more often in Stage Ib disease than in Stage 0, and it was not observed in benign tumors. These results suggest that stimulation with some antigens (e.g., cancer antigen in the current study) is necessary to induce immunoaugmentation by sizofiran which has no antigenicity. The augmenting effect was seen even in lymph nodes involved by advanced cervical cancer. Therefore, sizofiran was found to be a potent biologic response modifier in patients with cervical cancer.
Abrogation of the invasion of human bladder tumor cells by using protease inhibitor(s)
Authors: Redwood S. Mark , Liu Brian C.‐S. , Weiss Robert E. , Hodge Derrick E. , Droller Michael J. 
Published: August 2010

AbstractIt was shown previously that invasive human transitional cell carcinoma cell line EJ, but not the noninvasive RT4 cells, can degrade basement membrane laminin and that the degradation of basement membrane laminin was a result of a redistribution of activated cysteine proteinase cathepsin B to the plasma membrane of the invasive EJ cells. Using a modified Boyden chamber and an artificial basement membrane, it was found first that cysteine proteinase inhibitor E‐64 can abolish the ability of the EJ cells to invade through the artificial basement membrane to the underside of the filter. Second, E‐64 can prevent the degradation of purified human basement membrane laminin by the plasma membrane fraction of invasive EJ cells. Third, E‐64 does not affect the ability of the EJ cells to attach to the extracellular matrix nor is the inhibitory dose toxic to the cells when assayed with trypan‐blue dye exclusion. However, E‐64 does affect the ability of the EJ cells to respond to autocrine motility factor‐induced motility. Finally, in an in vivo model, E‐64 was not toxic to the animals tested and may have limited the blood‐borne metastatic ability of invasive EJ cells in the treated animals. It was concluded that proteinase cathepsin B may be involved in human bladder tumor invasion, in both extracellular matrix degradation and factor‐induced cellular motility, and the authors suggested that the use of inhibitor(s) to cysteine proteinases may limit the invasive potential of human bladder cancer cells.
A phase II randomized study comparing sequential and combined intraarterial cisplatin and radiation therapy in primary brain tumors: A southwest oncology group study
Authors: Mortimer Joanne E. , Crowley John , Eyre Harmon , Weiden Paul , Eltringham James , Stuckey W. J. 
Published: August 2010

AbstractThe Southwest Oncology Group conducted a trial of intraarterial cisplatin (150 mg intravenously every 21 days for 2 doses) administered concomitant with or before radiation therapy. Because of technical difficulties cannulating the artery, 27 of 33 eligible patients were able to receive the cisplatin by arterial injection. Five patients died before completion of the study, and 11 patients in each treatment arm were evaluable for response. Three patients (27%) had an objective tumor regression in each treatment arm. Thromboembolic problems complicated 8 of 57 (14%) chemotherapeutic courses. The median survival for the 33 eligible patients was comparable for both groups: 10.8 months in the concomitant treatment arm and 9.6 months with sequential therapy. Problems related to drug administration and toxicity made it impossible to determine the role of intraarterial cisplatin in the initial management of primary high‐grade gliomas.
Prognostic factors for survival and tumor control in cervical lymph node metastases from head and neck cancer: A multivariate study of 492 cases
Authors: Cerezo Laura , Millan Isabel , Torre Alejandro , Aragon Gregorio , Otero Jose 
Published: August 2010

AbstractA multivariate analysis was carried out in 492 patients with metastatic neck disease from squamous cell carcinoma to determine the influence of clinical and therapeutic factors on survival, local and regional control, and distant metastases. After radiation treatment with radical intent, recurrence at the primary site was the most frequent site of treatment failure (20% of cases), followed by distant metastases (14% of the cases), whereas isolated neck recurrences occurred in only 7% of the patients. The most significant factors influencing survival were primary tumor site, node fixation, N‐stage, T‐stage, and number of lymphatic chains, The most significant factors influencing local control were primary site, T‐stage, and node fixation. Significant factors influencing regional control were radiation therapy volume, primary tumor site, node fixation, and node location (upper and lower neck). Significant factors influencing distant control were N‐stage, number of nodes, and number of involved lymphatic chains.
Hodgkin's disease and non‐hodgkin's lymphoma containing reed‐sternberg‐like giant cells in Taiwan: A clinicopathologic analysis of 50 cases
Authors: Hong Ruey‐Long , Su Ih‐Jen , Chen Yao‐Chang , Hsieh Hong‐Chong , Wang Chiu‐Hwa , Liu Chien‐Hui , Shen Ming‐Ching 
Published: August 2010

AbstractHodgkin's disease (HD) is uncommon in Taiwan. In reviewing the clinicopathologic features of 50 cases, the authors found that the diagnosis of HD was complicated with non‐Hodgkin's lymphoma (NHL). Fourteen cases were reclassified as NHL containing Reed‐Sternberg (RS) giant cells, mostly peripheral T‐cell lymphoma (PTL), and 34 cases as classic HD, which included 8 cases of lymphocyte predominance, 10 of nodular sclerosis, 12 of mixed cellularity, and 4 of lymphocyte depletion. For cases of HD, there was a bimodal age‐incidence distribution with peaks at the third and fifth decades; 61.8% manifested Stage B symptoms and 80.6% had Stage III/IV disease. The group of patients with NHL, compared with those with classic HD, was found to be older (mean age, 41.4 yearsversus33.1 years;P <0.05), to have more extranodal disease (35.7%versus8.8%,P <0.05), less complete remission rate (25%versus67.9%,P <0.05), and shorter median survival (29 monthsversus90 months). Most of the NHL patients originally were diagnosed as having atypical or unclassified HD. Thus, the authors conclude that the previous observation of a predominance of mixed cellularity HD in Asian regions may be attributable to the inclusion of PTL, which may mimic HD in histology. Because there is a marked difference in clinical behavior and prognosis, it is important to distinguish between HD and NHL containing RS giant cells in an area with a high incidence of PTL.
Paraneoplastic encephalomyelitis: Dramatic response to chemotherapy alone
Authors: Batson Oliver A. , Fantle David M. , Stewart James A. 
Published: August 2010

AbstractNeurologic paraneoplastic syndromes are usually a debilitating and untreatable manifestation of malignancy. The case is presented of a woman with severe paraneoplastic encephalomyelitis that was characterized predominantly by cerebellar degeneration associated with small cell lung cancer, both of which responded rapidly to cytotoxic chemotherapy alone. She is alive with some neurologic residua but no signs of recurrent cancer more than 2 years after diagnosis. Recommendations for aggressive management of this rare but disabling syndrome are outlined.
Familial occurrence of infantile myofibromatosis
Authors: Bračko Matej , Cindro Lada , Golouh Rastko 
Published: August 2010

AbstractTwo brothers with multicentric infantile myofibromatosis (IM) are reported. In both, tumors were present at birth; the tumors regressed spontaneously, but new lesions developed throughout the follow‐up periods of 15 and 8 years. Immunohistochemically, the nodules were found to be positive for vimentin and actin, but negative for desmin and S‐100 protein; these findings support the myofibroblastic nature of IM. A literature review revealed nine additional families with IM in more than one family member. Although the occurrence of IM in eight sets of siblings, with consanguinity in two of them, favors an autosomal recessive mode of inheritance, the disorder also has been well documented in half‐sisters and in successive generations, which makes autosomal dominant inheritance a more plausible explanation.
DNA content and other prognostic features in childhood medullohlastoma: Proposal of a scoring system
Authors: Schofield Deborah E. , Yunis Eduardo J. , Geyer J. Russell , A. Leland Albright  , Berger Mitchel S. , Taylor Suzanne R. 
Published: August 2010

AbstractThe authors reviewed clinical features, surgical extent of resection, histologic parameters, and DNA content in 55 children with medulloblastomas and found that complete or near total resection, absence of tumor dissemination, tumor DNA aneuploidy, and low proliferative index correlated with a favorable clinical outcome. A scoring system was developed based upon these features to identify patients who, in the future, may beneit from more aggressive or novel therapeutic regimens. Patient age and sex and adjuvant chemotherapy did not significantly correlate with long‐term survival. The data also suggest that tumors that have been designated as cerebellar neuroblastomas may be a distinct group of posterior fossa tumors, which may have a better prognosis.
Building decentralized resource space on a structured P2P network
Authors: Chen Xue , Zhang Junfeng 
Published: August 2010

AbstractResource Space Model (RSM) is a normalized classification model that usesm‐dimensional semantic spaces to share and manage various resources in a centralized manner. The Resource Space is a semantic coordinate system that can support SQL‐like multi‐dimensional range queries, but lack automatic construction mechanism and the efficient search algorithm for query routing in the dynamic and decentralized environment. This paper first partitions a centralized Resource Space into a number of decentralized sub‐spaces based on the classification semantics and dimension locality of RSM, and then deploys these sub‐spaces onto a ring‐structured P2P topology HRing that is able to totally preserve the classification semantics and dimension locality of RSM. After that, we build the routing tables, define the dynamic resource operations and propose an efficient routing algorithm for multi‐dimensional range queries on the decentralized P2P Resource Space. Theoretical analysis and simulations show that the construction and maintenance cost, as well as the search performance can reach logarithmic scale. Thus, the decentralized P2P Resource Space can be applied on dynamic and large‐scale resource‐sharing systems. Copyright © 2010 John Wiley & Sons, Ltd.
Characterization of midgut stem cell‐ and enteroblast‐specific Gal4 lines in drosophila
Authors: Zeng Xiankun , Chauhan Chhavi , Hou Steven X. 
Published: August 2010

AbstractThe homeostasis of Drosophila midgut is maintained by multipotent intestinal stem cells (ISCs), each of which gives rise to a new ISC and an immature daughter cell, enteroblast (EB), after one asymmetric cell division. In Drosophila, the Gal4‐UAS system is widely used to manipulate gene expression in a tissue‐ or cell‐specific manner, but in Drosophila midgut, there are no ISC‐ or EB‐specific Gal4 lines available. Here we report the generation and characterization of Dl‐Gal4 and Su(H)GBE‐Gal4 lines, which are expressed specifically in the ISCs and EBs separately. Additionally, we demonstrate that Dl‐Gal4 and Su(H)GBE‐Gal4 are expressed in adult midgut progenitors (AMPs) and niche peripheral cells (PCs) separately in larval midgut. These two Gal4 lines will serve as invaluable tools for navigating ISC behaviors. genesis 48:607–611, 2010. Published 2010 Wiley‐Liss, Inc.
Neue Leitstrukturen aus dem Computer
Authors: Barnickel Gerhard , Gasteiger Johann , Klebe Gerhard , Levy Paul , Zell Andreas 
Published: August 2010

AbstractChemiker, Pharmazeuten, Mathematiker und Informatiker aus Hochschule und Industrie arbeiten in einem vom BMBF geförderten Projekt zusammen, um Computermethoden zum Auffinden neuer Leitstrukturen und Wirkstoffe zu entwickeln. Schwerpunktmäßig kommen dabei neuronal Netze und genetische Algorithmen zum Einsatz.
Chemische Technik, Biotechnologie, Umweltschutz
Authors: Hirche Christina 
Published: August 2010

AbstractDas größte Fachtreffen innerhalb des breitgefächerten Programms hatten wieder die Biotechnologen mit ihrer 14. Jahrestagung, bei der sich auch der Hochschullehrernachwuchs vorstellte. Beschlossen wurde, eine Vereinigung deutscher Biotechnologie‐Unternehmen zu gründen. Neu: die Fachsektion Reaktionstechnik und ein Informationstag Sonochemie.
Standort D — bei Erfindungen in Europa vorn
Authors: Wirth Wolf‐Dieter 
Published: August 2010

AbstractDas Europäische Patentamt schafft in einem einzigen Patentanmeldungs‐ und Erteilungsverfahren die Schutzvoraussetzungen für nunmehr 18 europäische Staaten. Dieser rationelle Weg zum Europäischen Patent wird besonders von der Industrie intensiv genutzt.
Chemische Information für das nächste Jahrhundert
Authors: Ihlenfeldt Wolf‐Dietrich 
Published: August 2010

AbstractDie zur Zeit anlaufende digitale Vernetzung wird für Chemiker weit mehr bringen als e‐mail und Dokumentenaustausch via Internet. Die Arbeitsweisen eines Forschers, vor allem Literaturrecherche und Publizieren, werden sich in Zukunft drastisch verändern.
Chemiestandort Neue Bundesländer
Authors: Hauthal H. G. 
Published: August 2010

AbstractDie ostdeutsche Chemieproduktion wuchs 1995 zwar um 20,7 Prozent auf 8,9 Milliarden DM, doch entspricht dies erst fünf Prozent des deutschen Chemieumsatzes. Die Produktivität hat 64 Prozent des westdeutschen Niveaus erreicht. Die Privatisierung ist im Prinzip abgeschlossen.
Automatisierung im Labor: Liquid handling
Authors: Bauer Hermann , Kinkel Joachim , Stark Walter , Volgnandt Peter 
Published: August 2010

AbstractDie Automatisierung im analytischen Labor umfaßt alle Tätigkeitsbereiche von der Probennahme bis zur Dokumentation. Ein essentielles Teilgebiet stellt das Liquid Handling dar. Das kommerzielle Angebot reicht dabei vom einfachen Einzelbaustein bis zum vollautomatisierten Gesamtsystem.
Feasibility of a self‐help treatment for insomnia comorbid with cancer
Authors: Savard Josée , Villa Julie , Simard Sébastien , Ivers Hans , Morin Charles M. 
Published: August 2010

AbstractObjective: Professionally administered cognitive‐behavioral therapy (CBT) is efficacious for treating insomnia in breast cancer survivors. However, given the limited accessibility to CBT for insomnia in cancer clinics, there is a need to develop other delivery formats for this intervention. This feasibility study examined patients' satisfaction with a self‐help CBT for insomnia comorbid with cancer and gathered some preliminary data on its effect on sleep and associated features.Methods: Eleven breast cancer patients reporting insomnia symptoms received a 6‐week intervention composed of a 60‐min video using an animated cartoon format and 6 short booklets developed in French. Patients completed a semi‐structured interview at post‐treatment, a battery of self‐report scales and a daily sleep diary (14 days) at pre‐ and post‐treatment and at a 3‐month follow‐up.Results: At post‐treatment interview, comments about the treatment material were uniformly positive. On a questionnaire, patients also reported to be satisfied with the treatment overall, with the video and the booklets' content, as well as with their sleep improvement at post‐treatment (scores from 2.7 to 3.1; scale from 0 to 4). From pre‐ to post‐treatment, moderate‐to‐large effect sizes and statistically and clinically significant differences were found on most sleep variables, as well as overall quality of life. These therapeutic gains were well sustained at a 3‐month follow‐up.Conclusions: Patients were satisfied with the treatment received. Although it is too early to draw any firm conclusion, treatment outcomes suggest a potential for integration into routine cancer care as a first‐line sleep management intervention. Copyright © 2010 John Wiley & Sons, Ltd.
Preparation, Crystal Structure, Thermal Decomposition, and Explosive Properties of [Cd(en)(N3)2]n
Authors: Yang Li , Wu Bidong , Zhang Tonglai , Liu Zhenhua , Zhang Jianguo 
Published: August 2010

AbstractA new multi‐ligand coordination polymer of cadmium(II) ethylenediamine azide, [Cd(en)(N3)2]n (en=ethylenediamine), was synthesized and characterized by using elemental analysis and FT‐IR spectrum. Its crystal structure was determined by means of X‐ray single crystal diffraction. The obtained results show that this crystal belongs to monoclinic, P21/n space group, a=0.6548(1) nm, b=1.0170(2) nm, c=1.2246(2) nm, β=90.23(1)°, V=0.8156(2) nm3, Dc=2.090 g⋅cm−3, Z=4, R1=0.024, wR2 (I>2σ(I))=0.0416 and S=0.998. The Cd(II) ion is six‐coordinated with four azido ligands by μ‐1, 1 azido bridges, and two ethylenediamine molecules which serve as bidentate ligands through the nitrogen atoms. The thermal decomposition mechanism of the title complex was studied by using differential scanning calorimetry (DSC) and thermogravimetry‐differential thermogravimetry (TG–DTG) techniques. Under nitrogen atmosphere with a heating rate of 10 K⋅min−1, the thermal decomposition of the complex contains two main successive exothermic processes between 519 and 701 K in the DSC curve, and the final decomposed residue at 725 K is Cd. The non‐isothermal kinetics parameters were calculated by using the Kissinger's method, Ozawa–Doyle's method, pervasive integration method, and differential method, respectively. The sensitivity properties of [Cd(en)(N3)2]n were also determined with standard methods.
Characterization of de novo transcriptome for waterhemp (Amaranthus tuberculatus) using GS‐FLX 454 pyrosequencing and its application for studies of herbicide target‐site genes
Authors: Riggins Chance W , Peng Yanhui , Stewart C Neal , Tranel Patrick J 
Published: August 2010

AbstractBACKGROUND: Waterhemp is a model for weed genomics research in part because it possesses many interesting biological characteristics, rapidly evolves resistance to herbicides and has a solid foundation of previous genetics work. To develop further the genomics resources for waterhemp, the transcriptome was sequenced using Roche GS‐FLX 454 pyrosequencing technology.RESULTS: Pyrosequencing produced 483 225 raw reads, which, after quality control and assembly, yielded 44 469 unigenes (contigs + singletons). A total of 49% of these unigenes displayed highly significant similarities to Arabidopsis proteins and were subsequently grouped into gene ontology categories. Blast searches against public and custom databases helped in identifying and obtaining preliminary sequence data for all of the major target‐site genes for which waterhemp has documented resistance. Moreover, sequence data for two other herbicide targets [4‐hydroxyphenylpyruvate dioxygenase (HPPD) and glutamine synthetase], where resistance has not yet been reported in any plant, were also investigated in waterhemp and six related weedy Amaranthus species.CONCLUSION: These results demonstrate the enormous value of 454 sequencing for gene discovery and polymorphism detection in a major weed species and its relatives. Furthermore, the merging of the 454 transcriptome data with results from a previous whole genome 454 sequencing experiment has made it possible to establish a valuable genomic resource for weed science research. Copyright © 2010 Society of Chemical Industry
White matter is altered with parental family history of Alzheimer's disease
Authors: Bendlin Barbara B. , Ries Michele L. , Canu Elisa , Sodhi Aparna , Lazar Mariana , Alexander Andrew L. , Carlsson Cynthia M. , Sager Mark A. , Asthana Sanjay , Johnson Sterling C. 
Published: August 2010

BackgroundBrain alterations in structure and function have been identified in people with risk factors for sporadic type Alzheimer's disease (AD), suggesting that alterations can be detected decades before AD diagnosis. Although the effect of apolipoprotein E (APOE) ɛ4 on the brain is well‐studied, less is known about the effect of family history of AD. We examined the main effects of family history and APOE ɛ4 on brain integrity, in addition to assessing possible additive effects of these two risk factors.MethodsDiffusion tensor imaging was performed in 136 middle‐aged asymptomatic participants stratified on family history and APOE ɛ4. Mean diffusivity and fractional anisotropy (FA) were entered in factorial analyses to test the effect of AD risk on microstructural brain integrity. We performed a post hoc analysis of the three principal diffusivities (λ1, λ2, λ3) to provide potential additional insight on underlying tissue differences.ResultsParental family history of AD was associated with lower FA in regions of the brain known to be affected by AD, including cingulum, corpus callosum, tapetum, uncinate fasciculus, hippocampus, and adjacent white matter. Contrary to previous reports, there was no main effect of APOE ɛ4; however, there was an additive effect of family history and APOE ɛ4 in which family history–positive participants who were also APOE ɛ4 carriers had the lowest FA compared with the other groups.ConclusionsThe data indicate that unknown risk factors contained in family history are associated with changes in microstructural brain integrity in areas of the brain known to be affected by AD. Importantly, the results provide further evidence that AD pathology might be detected before cognitive changes, perhaps decades before disease onset.
Neolithic agriculture, freshwater resources and rapid environmental changes on the lower Yangtze, China
Authors: Qin Jungan , Taylor David , Atahan Pia , Zhang Xinrong , Wu Guoxuan , Dodson John , Zheng Hongbo , Itzstein-Davey Freea 
Published: August 2010

AbstractAnalyses of sedimentary evidence in the form of spores, pollen, freshwater algae, dinoflagellate cysts, phytoliths and charcoal from AMS 14C-dated, Holocene-aged sequences provide an excellent opportunity to examine the responses of Neolithic agriculturalists in the lower Yangtze to changing environments. Evidence from two sites close to the southern margin of the Yangtze delta and separated by what is now Hangzhou Bay attests the critical importance to early attempts at food production of access to freshwater resources. More readily, if episodically, available freshwater resources during the early to mid-Holocene on the Hangjiahu plain may have encouraged an early reliance on rice-based agriculture, which in turn facilitated the accumulation of agricultural surpluses and cultural diversification. Cultural change was relatively attenuated and human population pressures possibly lower on the Ningshao plain, seemingly because of much more profound environmental impacts of variations in local hydrological conditions, and because predominantly saline conditions, associated with rising relative sea level, hampered the early development of irrigated agriculture. The evidence, although largely dating to the early and middle parts of the Holocene, provides a timely warning of the complexity of vulnerability to climate change-induced processes of agriculture, and indeed human activities more generally, on megadeltas in Asia.