bluuebunny/crossref_metadata_2025_split huggingface dataset:
Super-specialty Medical Teleconsultations to Remote Areas of Ladakh, India via E-Sanjeevani under Hub-and-Spoke Model: A Pilot Study
Authors: Jain Siddharth , Arora Shreya , Chauhan Anil , Agarwal Amit , Saikia Biman , Singh Meenu 
Published: May 2024

Objectives: To assess the feasibility, spectrum, outcomes and challenges of delivering super-specialty consultations to remote areas of the Union Territory (UT) of Ladakh through telemedicine.
Design: Prospective, observational (descriptive), pilot study
Methodology: Super-specialty medical teleconsultations were provided to healthcare providers in UT Ladakh by specialists in the Department of Telemedicine, Postgraduate Institute of Medical Education and Research, Chandigarh from October 2021 to May 2022, employing the hub-and-spoke model of the Ayushman Bharat Digital Mission. Doctor-to-doctor teleconsultations were initiated by treating doctors at healthcare facilities in UT Ladakh on the eSanjeevani™ platform. Audio-video model was used for teleconsultation and digitally signed prescriptions were shared.
Setting: India – Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh (hub) and healthcare providers in UT Ladakh (spokes)
Participants: Healthcare providers in UT Ladakh and specialists in the Department of Telemedicine, PGIMER, Chandigarh
Interventions: Super-specialty medical consultations using telemedicine (eSanjeevani™ platform)
Main Outcome Measures: Demand and spectrum of superspecialty teleconsultations, outcome of consults (whether managed successfully at teleconsultation level, or required referral for in-person visits), and technical challenges faced.
Results: A total of 26 super-specialty teleconsultations were provided; 14 (54%) were for women. Patient distribution was uniform across all age groups. The super-specialty-wise distribution of consultations was - 9 from endocrinology, 9 from neurology, 3 from hepatology, 2 from cardiology, and 3 from neonatology. Reasons for seeking consultation were assistance in diagnosis (3, 12%), optimization of therapy (10, 38%), or both diagnostic evaluation and treatment optimization (13, 50%). Five cases (19%) were referred for physical visits to a higher center for advanced diagnostic testing like liver biopsy, brain biopsy, upper GI endoscopy, etc.; other cases were managed remotely. Problems with audio-visual connectivity were encountered in three patients.
Conclusion: This pilot study demonstrates that complex, super-specialty medical consultations can be effectively delivered to remote areas through telemedicine. Future research should focus on assessing long-term outcomes, patient satisfaction, and cost-effectiveness to better evaluate the impact of this model.
The Impact of Covid-19 on Urban Planning of Port Harcourt City, Nigeria
Authors: Odigwe Moses , Mchi Akaawase Alexander 
Published: May 2024

Background: Coronavirus disease is a communicable and contagious respiratory disease that has not only affected human social lives, interactions and relationships but equally changed other significant patterns of people’s normal lives, and there is need for a robust urban planning to meet the emerging changes. This study sought to investigate how the COVID-19 pandemic has affected the inhabitants of Port Harcourt City and its implications on urban planning in Port Harcourt City, Nigeria. This study examined how the COVID-19 pandemic affected human interactions and business activities, and its implication on urban planning in Port Harcourt city.
Methods: The study adopted descriptive survey design with questionnaire used for data collection. Port Harcourt inhabitants aged 18 years and above were studied using four major clusters in Port Harcourt city. Purposive sampling technique was used to select participants from five most affected COVID-19 business areas in each cluster in the year 2020. A total of 400 participants assessed on people’s economic activities and welfare attributes using Likert-scale. Data were analysed using simple percentages, mean and standard deviation.
Results: Major findings revealed that COVID-19 negatively affected the lives of people, closure of markets and other economic centres, lack of face-to-face communication and interaction, change in people’s social welfare and lifestyle, to halt in education and academic activities, restriction in movement and transportation, and household welfare challenges. It is suggested that policymakers should intensify efforts to ensure coronavirus is eradicated by providing COVID-19 drugs to all Nigerians.
Conclusion: The study underscores the urgent need for comprehensive measures to mitigate the multifaceted impacts of COVID-19 in Nigeria, emphasizing equitable access to essential medications as a crucial strategy for combating the pandemic's adverse effects on society.
Novelty: This research offers novel insights into the broad-ranging impacts of COVID-19 on various aspects of life in Nigeria, highlighting the imperative of equitable access to medications as a pivotal solution.
Education Policies and Practices for Ensuring Quality Education in Nepal
Authors: Acharya Bisna 
Published: May 2024

Background: Nepal's education policies and practices focus on enhancing the quality of education by implementing guidelines, regulations, and initiatives established by the government and educational institutions. The policies and practices are carefully crafted to address various aspects of the education system, ensuring that all students can access equitable, thorough, and effective educational opportunities.
Objectives: This study examines the education policies and practices implemented in Nepal to ensure high-quality education.
Method: An analytical and descriptive research design has been applied to analyze the data. Data were collected through a comprehensive field survey. Questionnaires were distributed to students, teachers, and guardians, while head teachers were interviewed. Additionally, policy experts and local leaders participated in a focused group discussion.
Results: The study found a strong correlation between various dimensions of quality education and the overall quality of education. Specifically, motivation, teaching-learning pedagogy, school environment, and training and development were found to be statistically significant in improving the quality of education. However, no significant relationship was found between resources and the quality of education. The regression results also showed similar findings.
Conclusion: Based on the hypothesis, it can be inferred that there was a positive impact of motivation, teaching-learning pedagogy, school environment, and training and development on the quality of education, even in primary and basic education settings. The study suggests that resources do not have a significant impact on the quality of education in primary and basic education.
Novelty: The researcher has expected that by implementing education acts, policies, and programs, Nepal's school education will be improved ensuring education quality.
Gender, clinical and instrumental parallels of Lp(a) levels in patients with very high cardiovascular risk
Authors: Mitchenko O. I. , Bila Y. O. , Bilyi D. O. 
Published: May 2024

In recent years it has been established that elevated levels of Lp(a) are an independent genetic risk factor for the development of atherosclerotic cardiovascular diseases and aortic stenosis, however, issues of gender and age characteristics remain controversial.The aim of study was to analyze the gender characteristics of the relationship between Lp(a) levels and atherogenic changes in the lipid spectrum of the blood, clinical and instrumental characteristics, taking into account damage to the aortic valve and the results of coronary angiography in patients with stable coronary heart disease. Materials and methods. The 106 patients with chronic coronary heart disease (CAD) were examined. The average age of the subjects was 55.00±1.0 years (95% CI 51.11-58.89), among them: 78 men and 28 women.The entire cohort of patients was divided depending on the Lp(a) levels: 1group (n=58) with a Lp(a) level less than 50 mg/dl; 2 group (n=20) with Lp(a) level 50-100 mg/dl; 3 group (n=8) with Lp(a) level 101-150 mg/dl and 4 group (n=20) with Lp(a) level more than 150 mg/dl.Research methods included: 1. General clinical examination; 2. Laboratory characteristics of lipid (with determination of Lp(a)) and carbohydrate metabolism, as well as standard biochemical parameters; 3. Instrumental examination (electrocardiography, echocardiography, ultrasound peripheral vessels examination, coronary angiography); 4. Mathematical and statistical processing of the results obtained.Results and conclusions. In patients with CAD verified by clinical-instrumental and coronary angiographic criteria, it is noted that Lp(a) levels in women are on average significantly higher (P< 0.05) than in men and increase with the onset of menopause.Close correlations have not been recorded between Lp(a) in mg/dL and total cholesterol, LDL cholesterol and non-HDL cholesterol, as well as the concentrations of glucose, glycosylated hemoglobin, serum creatinine, and the concentration of thyroid-stimulating hormone (TSH).Determined that in patients with documented atherosclerotic lesions of the coronary arteries against the Lp(a) levels above 100 mg/dl, there is a greater need for coronary revascularization. A close relationship is observed between the increase in Lp(a) levels and the percentage of detection of aortic stenosis, which confirms the pathogenetic role of this lipoprotein in the formation of this acquired aortic valve disease.
Perbedaan Kemampuan Komunikasi Matematik Siswa Antara Yang Mendapatkan Model Pembelajaran Jigsaw Dan Cooperative Script
Authors: Sulastri Susi , Haq Cici Nurul 
Published: May 2024

This research is done because a lot of students who have difficulty in understanding the concepts of mathematics. Based formulation of the problem in this study, i.e. whether there is a difference between the students' mathematical communication skills are getting instructional model jigsaw premises cooperative script? . the study aims to determine differences in mathematical ability of communication between the students who get the Jigsaw cooperative learning model script. This research was conducted using a quasi-experimental. The instrument used to measure the communication skills of mathematics that is shaped in the form of a written test descriptions. Tests administered before researcher provide treatment (pretest) and after treatment (posttest), about the same as the pretest posttest questions. Based on data from the pretest and posttest results, both normal distribution and homogeneous so that data processing followed by t-test, thus Ho is accepted. The results of this study indicate that there is no difference between the students' mathematical communication skills that get the Jigsaw cooperative learning model script.
Penelitian ini dilakukan karena banyak siswa mengalami kesulitan dalam memahami konsep-konsep matematika.Berdasarkan rumusan masalah dalam penelitian ini, yaitu “apakah terdapat perbedaan kemampuan komunikasi matematik siswa antara yang mendapatkan model pembelajaran Jigsaw dan Cooperative Script?”, maka penelitian ini bertujuan untuk mengetahui perbedaan kemampuan komunikasi matematik siswa antara yang mendapatkan model pembelajaran Jigsaw dengan Cooperative Script. Penelitian ini dilakukan dengan menggunakan metode quasi eksperimen.Berdasarkan data hasil pretest dan postest, keduanya berdistribusi normal dan homogen sehingga pengolahan data dilanjutkan dengan Uji t,dengan demikian Ho diterima. Hasil dari penelitian ini menunjukkan bahwa tidak terdapat perbedaan kemampuan komunikasi matematik siswa antara yang mendapatkan model pembelajaran Jigsaw dengan Cooperative Script.
Perbandingan Kemampuan Pemecahan Masalah Matematika Antara Siswa Yang Mendapatkan Strategi Giving Reward Dengan Konvensional
Authors: Nurulhaq Hilma , Margana Akhmad 
Published: May 2024

Research using experimental methods with the group design is randomized control group pre-test-posttest design, with this method, the file that will be examined are group into two classes namely the control class and the experimental class. Instrument used to measure the ratio of the mathematical problem-solving skills is objective test or description test be given before researcher provide treatment and after treatment. File analyses performed using Chi Squared test and Mann-Whitney test. This study aimed to knowing the ratio of the mathematical problem-solving skills between students who get giving reward strategies with students who get conventional learning. The results of research showing that the mathematical problem-solving skills between students who get giving reward strategies better than students who get conventional learning.
Penelitian dengan menggunakan metode eksperimen dengan desain kelompok randomized control group pre-test-postest design, dengan metode tersebut data yang akan diteliti dikelompokan menjadi dua yaitu kelas kontrol dan kelas eksperimen. Instrumen yang digunakan untuk mengukur perbandingan kemampuan pemecahan masalah matematika yaitu berupa tes objektif / uraian yang diberikan sebelum peneliti memberikan perlakuan dan sesudah perlakuan. Analisis data dilakukan dengan menggunakan Uji Chi Kuardat dan Uji Mann-Whitney. Penelitian ini bertujuan untuk mengetahui perbandingan kemampuan pemecahan masalah matematika antara siswa yang mendapatkan strategi giving reward dengan siswa yang mendapatkan pembelajaran konvensional. Hasil penelitian ini menunjukkan bahwa kemampuan pemecahan masalah matematika antara siswa yang mendapatkan strategi giving reward lebih baik dibandingkan dengan siswa yang mendapatkan pembelajaran konvensional.
Pendekatan Contextual Teaching And Learning Untuk Meningkatkan Prestasi Belajar Pada Bidang Matematika
Authors: Sadiyono Bambang , Sri  
Published: May 2024

Untuk meningkatkan prestasi belajar siswa khususnya pada mata pelajaran matematika, salah satu caranya adalah dengan menggunakan pendekatan CTL, karena dalam pendekatan CTL disamping pembelajarannya dihubungkan dengan kehidupan sehari-hari, anak juga dituntut aktif dalam memecahkan masalah. Dalam penelitian ini desain penelitiannya yang digunakan adalah deskriftif korelasional dari hasil penelitian diperoleh hubungan yang signifikan antara pendekatan CTL dengan prestasi belajar siswa dibidang matematika sebesar 0,612. Ini menunjukan tingkat korelasinya sangat kuat dimana fhitung(7,198) > ftabel (4,75) sehingga hipotesis alternatif (Ha) diterima, artinya terdapat hubungan yang signifikan antara pendekatan CTL dengan prestasi belajar siswa dibidang matematika.
Perbandingan Prestasi Belajar Siswa Antara Yang Mendapatkan Model Pembelajaran Snowball Throwing Dan Pembelajaran Konvensional
Authors: Delisda Dede , Sofyan Deddy 
Published: May 2024

Tujuan penelitian ini adalah membandingkan dua model pembelajaran yaitu model pembelajaran Snowball Throwing dan Pembelajaran konvensional untuk melihat sejauh mana kedua model pembelajaran tersebut berperan dalam meningkatkan prestasi belajar siswa. Peneliti ingin melihat apakah prestasi belajar siswa yang mendapatkan model Snowball Throwing lebih baik dibandingkan dengan yang mendapatkan model konvensional. Metode yang peneliti gunakan adalah metode eksperimen, yaitu dengan cara memberikan perlakuan pada dua kelas sampel yang berbeda. Populasi pada penelitian ini adalah seluruh siswa kelas X SMAN 15 Garut dengan sampel kelas dipilih secara acak yaitu X-6 dan X-8.Instrumen yang digunakan untuk mengukur prestasi belajar siswa yaitu berupa tes objektif, diberikan sebelum peneliti memberikan perlakuan (pre-test) dan sesudah perlakuan (post-test).Berdasarkan hasil penelitian tes awal terdapat data yang tidak berdistribusi normal pada keduanya sehingga pengolahan data dilanjutkan dengan Uji Mann Whitney Selain itu penelitiani ini juga mengulas mengenai kategori peningkatan prestasi belajar siswa kelas eksperimen antara kelompok tinggi, sedang, dan rendah dengan hasil peningkatan pada masing-masing kelompok tergolong sedang.
Perbedaan Kemampuan Pemecahan Masalah Matematika Antara Kelompok Siswa Yang Mendapatkan Pembelajaran Kooperatif Tipe Teams Games Tournament (TGT) Dengan Student Teams Achievements Divisions (STAD)
Authors: Yasa  , Madio Sukanto Sukandar 
Published: May 2024

This research uses two type cooperative learning, they are Teams Games Tournament and Student Teams Achievement Division. The study in this approach guided student’s attention to learn to understand the problem, how to, and what needed to solve mathematics problem. The purpose in this research is to know the difference of increase problem solving of mathematics student ability who use Teams Games Tournament and Student Teams Achievement Divisions, with the significant is 5 %. Increase problem solving student of mathematic ability student who gets cooperatives learning type Teams Games Tournament different with students who gets Student Teams Achievement Division learning.
Penelitian ini menggunakan 2 jenis pembelajaran kooperatif, yaitu Teams Games Tournament dan Student Teams Achievement Division. Pembelajaran kooperatif ini mengarahkan perhatian siswa untuk mempelajari, memahami masalah, bagaimana, dan apa yang dibutuhkan untuk menyelesaikan suatu masalah matematika. Tujuan penelitian ini adalah untuk mengetahui perbedaan peningakatan kemampuan pemecahan masalah matematik siswa yang menggunakan metode Teams Games Tournament dan Student Teams Achievement Division. Dengan taraf signifikan 5 %. peningkatan kemampuan pemecahan masalah matematik antara siswa yang mendapatkan pembelajaran kooperatif tipe Teams Games Tournament berbeda dengan siswa yang mendapatkan pembelajaran Student Teams Achievement Division.
Prevalence of Urinary Schistosomiasis among Primary School Pupils in Riverine Community of Garko Local Government Area, Kano State, Nigeria
Authors: Ahmad Abdullahi Garba , Bagwai M. A. 
Published: May 2024

Schistosomiasis is a neglected tropical disease that has become endemic in the riverine communities, primarily among school-age children, leading to school absenteeism. The study determines the prevalence of urinary Schistosomiasis and predisposition factors. A total of One hundred and fifty urine samples were examined for the presence of Schistosoma haematobium ova and detection of haematuria. The result obtained was tested using the Chi-Square test, and the overall prevalence was 53.3%. The infection rate was higher among males (58%) than the females (42%). The infection rate was higher among the ≥15 years age group (69.2%), while the 5-9 years age group had the least infection rate (47.2%). The study observed that the highest prevalence (62.0%) was recorded in Kafinchiri Primary School; this might be due to the influence of the water body in the community. The predisposition factors include gender, as males recorded the higher prevalence, which might be related to the economic activities such as irrigation, fishing, and laundry occurring in the riverine area. Age groups among the pupils had an impact on the prevalence of school absenteeism, and running away before closing hours is partially attributed to recreational activities, including swimming. Maintaining a safe distance between schools and water bodies and limiting frequent visits to the riverine area is crucial. The use of personal protective clothing and prompt treatment of infected persons should be encouraged to curtail the infection.
Identifying the RNA Binding Sites on the MeCP2 Protein by Regional Deletion
Authors: Mohan Ishita 
Published: May 2024

Long non-coding RNAs (LncRNAs) have been found to bind to the Methyl-CpG binding protein (MeCP2), which has been speculated to play a role in altering chromatin structure and regulating gene expression. Whether MeCP2 has other important functions related to RNA processing, the nature of the LncRNA-MeCP2 interaction and function, and how this may affect brain development is unknown. The goal of my project is to provide insight into important regions or domains of the MeCP2 protein involved in RNA binding. With this new information, a foundation for further in-depth research will be established, on the involvement of the MeCP2 protein in the pathogenesis of Rett Syndrome, through RNA binding and RNA regulation.
For the full text, please visit https://scholar.colorado.edu/concern/undergraduate_honors_theses/mw22v689v.
Sex-biased gene expression during neural differentiation of human embryonic stem cells
Authors: Pottmeier Philipp , Nikolantonaki Danai , Lanner Fredrik , Peuckert Christiane , Jazin Elena 
Published: May 2024

Sex differences in the developing human brain are primarily attributed to hormonal influence. Recently however, genetic differences and their impact on the developing nervous system have attracted increased attention. To understand genetically driven sexual dimorphisms in neurodevelopment, we investigated genome-wide gene expression in an in vitro differentiation model of male and female human embryonic stem cell lines (hESC), independent of the effects of human sex hormones. Four male and four female-derived hESC lines were differentiated into a population of mixed neurons over 37 days. Differential gene expression and gene set enrichment analyses were conducted on bulk RNA sequencing data. While similar differentiation tendencies in all cell lines demonstrated the robustness and reproducibility of our differentiation protocol, we found sex-biased gene expression already in undifferentiated ESCs at day 0, but most profoundly after 37 days of differentiation. Male and female cell lines exhibited sex-biased expression of genes involved in neurodevelopment, suggesting that sex influences the differentiation trajectory. Interestingly, the highest contribution to sex differences was found to arise from the male transcriptome, involving both Y chromosome and autosomal genes. We propose 13 sex-biased candidate genes (10 upregulated in male cell lines and 3 in female lines) that are likely to affect neuronal development. Additionally, we confirmed gene dosage compensation of X/Y homologs escaping X chromosome inactivation through their Y homologs and identified a significant overexpression of the Y-linked demethylase UTY and KDM5D in male hESC during neuron development, confirming previous results in neural stem cells. Our results suggest that genetic sex differences affect neuronal differentiation trajectories, which could ultimately contribute to sex biases during human brain development.