bluuebunny/crossref_metadata_2025_split huggingface dataset:
МІСЯЦЬ, СПІРАЛІ (ЗМІЇ) І БОГИНЯ У ТРИПІЛЬСЬКИХ ОРНАМЕНТАХ
Authors: Причепій Євген 
Published: June 2024

Дослідження трипільських орнаментів з місячною та зміїною тематикою важливе для проникнення в міфологію трипільців. Мета статті полягає в тому, щоб розкрити семантику символіки місяця та зміїв. В процесі дослідження застосовано структурний метод. Виділено восьми- та семичленні структури в орнаментах місяця. Досліджено семичленну структуру символів на кераміці з поселення Майданецьке. Показано, що за ними приховується сім (вісім) фаз місяця, які втілювали три (чотири) богині і чотири боги. Проаналізовано орнамент «біжуча спіраль». Ідентифіковано його як семичленну структуру, що передає фази місяця. Досліджено співвідношення жінки-Богині, місяця і спіралі (зміїв). Зроблено висновки, що: а) трипільці ототожнювали жінку-Богиню і місяць; б) символ спіралі (зміїв) на Богині позначав місяць. Поширення місячної та зміїної тематики в орнаментах свідчить про панування в культурі трипільців Богині Місяця. Проникнення в семантику місячно-зміїної тематики відкриває перспективу для розкриття змісту інших трипільських орнаментів та орнаментів споріднених з ними культур. Воно також може слугувати ключем для розкриття семантики деяких народних (в тому числі українських) орнаментів.
Management of Fish Pond Water Waste with Aquaponics Technology at Paguyuban Budiarta 7, Bululawang District, Malang Regency
Authors: Sri Rahayu Yekti , Muslimatul Mufida  , Sunyoto  
Published: June 2024

This service aims to provide solutions in the form of applying aquaponic technology to handle fish pond water waste. Aquaponic technology has the advantage of filtering wastewater to be channeled into vegetable growing media. The implementation method applied is training and assistance in aquaponic installation in the fish ponds of members of Paguyuban Budiarta 7. Aquaponic installation is in the form of installing pipes and water pumps from the fish pond to the vegetable growing media through filter and nutrient reservoirs. The results achieved are the installation of aquaponic systems in fish ponds can reduce the inundation of fish pond water waste, because the pond water is not directly discharged in the fish farming area, but channeled to the vegetable planting media, after being filtered in a water tank filled with charcoal. The results of observations of partner members show that around 90% of association members stated that this community service program provides benefits to increase knowledge and skills in diversifying fish and vegetable products through the aquaponics system. The sustainability of the program is highly expected to train members' expertise in producing energy sources through the use of solar cells, so that the use of electricity to support aquaponic installations can be more efficient and economical.
Efeitos agudos de diferentes volumes de alongamento estático inter-séries sobre o volume total de repetições em músculos agonistas: estudo experimental
Authors: Oliveira Fabio da Silva , Moreira Marcondes , Gonçalves Michel Moraes , Miranda Humberto Lameira 
Published: June 2024

Introdução: O alongamento tem sido comumente utilizado para incrementar a amplitude de movimento articular e a força muscular. Algumas evidências mostram que o alongamento pode promover efeitos deletérios no desempenho da força muscular. Entretanto, alguns estudos elucidam que o alongamento, quando aplicado nos músculos antagonistas, pode incrementar o desempenho da força dos agonistas.
Objetivo: Investigar os efeitos agudos de diferentes volumes (duração de aplicação) de alongamento estático (AE) de músculos antagonistas, inter-séries, no volume total de repetições no exercício remada aberta sentada, em homens treinados.
Métodos: Participaram 10 voluntários e selecionados por conveniência. Foram realizadas seis visitas com intervalos de 48 horas entre elas. A entrada nos protocolos experimentais, antes da execução da remada aberta sentada, foi aleatória e realizada em quatro dias; 1) Grupo método tradicional (GTRAD) – sem alongamento prévio; 2) AE com duração de 20s (G20); 3) AE com duração de 40s (G40) e 4) AE com duração de 60s (G60).
Resultados: Não foram observadas diferenças significativas entre os métodos de AE aplicados sobre o volume total de repetições (p=0,257; =1,476).
Conclusão: A utilização dos exercícios de alongamento estático de músculos antagonistas, entre as séries, independentemente do volume, parece não promover efeitos deletérios no desempenho de força de músculos agonistas. Portanto, baseado em tais achados, especula-se que essa pode ser uma boa estratégia a ser utilizada quando o objetivo for treinar força e flexibilidade na mesma sessão de treino, sem efeitos deletérios no desempenho da força muscular e gasto adicional de tempo da sessão.
The Graded Incomplete Letters Test (GILT): a rapid test to detect cortical visual loss, with UK Biobank implementation
Authors: Yong KXX , Petzold A , Foster P , Young A , Bell S , Bai Y , Leff AP , Crutch S , Greenwood JA 
Published: June 2024

AbstractImpairments of object recognition are core features of neurodegenerative syndromes, in particular posterior cortical atrophy (PCA; the ‘visual-variant Alzheimer’s disease’). These impairments arise from damage to higher-level cortical visual regions and are often missed or misattributed to common ophthalmological conditions. Consequently, diagnosis can be delayed for years with considerable implications for patients. We report a new test for the rapid measurement of cortical visual loss – the Graded Incomplete Letters Test (GILT). The GILT is an optimised psychophysical variation of a test used to diagnose cortical visual impairment, which measures thresholds for recognising letters under levels of increasing visual degradation (decreasing "completeness") in a similar fashion to ophthalmic tests. The GILT was administered to UK Biobank participants (total n=2,359) and participants with neurodegenerative conditions characterised by initial cortical visual (PCA, n=18) or memory loss (typical Alzheimer’s disease, n=9). UK Biobank participants, including both typical adults and those with ophthalmological conditions, were able to recognise letters under low levels of completeness. In contrast, participants with PCA consistently made errors with only modest decreases in completeness. GILT sensitivity to PCA was 83.3% for participants reaching the 80% accuracy cut-off, increasing to 88.9% using alternative cut-offs (60% or 100% accuracy). Specificity values were consistently over 94% when compared to UK Biobank participants without or with documented visual conditions, regardless of accuracy cut-off. These first-release UK Biobank and clinical verification data suggest the GILT has utility in both rapidly detecting visual perceptual losses following posterior cortical damage and differentiating perceptual losses from common eye-related conditions.
IL-10 Neutralization Attenuates Mast Cell Responses in a Murine Model of Experimental Food Allergy
Authors: Krajewski Dylan , Ranjitkar Saurav , Tedeschi Caitlin , Perez Nicole Maldonado , Jordan Nathan , Mire Mohamed , Schneider Sallie S , Mathias Clinton B 
Published: June 2024

Abstract
IgE-mediated mast cell (MC) activation is a critical component of allergic responses to oral Ags. Several T cell–derived cytokines have been shown to promote MC reactivity, and we recently demonstrated a critical role for the cytokine IL-10 in mediating MC responses during food allergy. In this study, we further validate the role of IL-10 using Ab-mediated IL-10 depletion. IL-10 neutralization significantly attenuated MC responses, leading to decreased MC accumulation and activation, as well as inhibition of MC-mediated symptoms such as allergic diarrhea. This was accompanied by decreased Th2 cytokine gene expression, attenuated systemic T cell responses, and fewer CD4 T cells, B cells, and MCs in the spleen. Our data further confirm the role of IL-10 in driving MC responses and suggest that IL-10–responsive MCs may constitute an important player in allergic responses.
Impact of Blue Light Intervention on Physiological Parameters and Circadian Rhythms: Insights from a Wistar Rat Model Study
Authors: Fatima Nazmin , Sonkar Gyanendra Kumar , Singh Sangeeta , Sonkar Satyendra Kumar , Mahdi Abbas Ali 
Published: June 2024

Abstract

Background:
This study investigates the impact of blue light-emitting diode (LED) lighting on the physiological responses of Wistar rats. The circadian system plays a vital role in regulating physiological functions, allowing organisms to anticipate and adapt to environmental rhythms. The synchronization of endogenous circadian clocks with external cues, such as light-dark cycles, is essential for optimal performance. However, emerging technologies, like blue LED lighting, present new challenges to circadian rhythms, highlighting the need for continued research in this area.

Methods:
The study, approved by the Animal Ethics Committee, involved a total of 12 male Wistar rats, which were divided into two groups: a Control group and a blue light (BL) treated group, each consisting of six rats. The BL model was established by subjecting the rats to 12 h of BL exposure daily for a period of 3 months. Half of the rats were sacrificed at the end of this period, while the remaining rats were transitioned to normal light (NL) conditions for another 3 months before being euthanized. Blood and tissue samples were collected for analysis, including measurements of body weight, blood glucose, insulin, melatonin, lipid profile, as well as messenger RNA expression by reverse transcription-polymerase chain reaction and global DNA methylation by enzyme-linked immunosorbent assay.

Results:
The study found that BL exposure led to a higher monthly increase in body weight, elevated blood glucose levels, and decreased insulin and melatonin levels compared to controls. BL also caused a decrease in total cholesterol, triglycerides, high-density lipoprotein, and low-density lipoprotein. Gene expression analysis revealed downregulation of Period1, Cryptochrome1, and brain and muscle arnt-like protein 1 (Bmal1) in blood and hypothalamus, with significant upregulation upon returning to NL conditions. BL exposure induced hypermethylation in DNA sequences, which partially reverted after returning to NL conditions.

Conclusion:
Our study reveals the broad impact of BL/artificial light contributing to a higher incidence of obesity and metabolic disorders. With the rise of blue-rich LED lighting, more research is needed to understand its long-term effects on health. This study contributes to a deeper understanding of the intricate relationship between BL exposure and metabolic health, emphasizing the importance of informed decisions regarding lighting technologies to mitigate potential health risks.
Serum miR-124a and miR-34a as Potential Biomarkers for Rheumatoid Arthritis
Authors: Zamzam Yosra Abdelmonem , Mansour Thanaa F. , Salem Rehab Mahmoud , Aziz Rania Salah Abdel , Elsendiony Sara Adel 
Published: June 2024

Abstract

Background:
MicroRNAs (miRs) are defined as noncoding small RNAs that are involved in the regulation of various immune functions, indicating they could be possible biomarkers for immune-mediated disorders. We aimed to evaluate miR-124a and miR-34a levels in serum as diagnostic biomarkers for rheumatoid arthritis (RA) and to investigate their correlation with the disease activity in RA patients.

Methods:
Our study consisted of 40 patients with RA and 40 controls. The disease activity for the RA patients was evaluated using the Disease Activity Score in 28 joints (DAS28). Relative quantification of miR-124a and miR-34a expressions in serum was conducted by reverse transcriptase quantitative real-time polymerase chain reaction.

Results:
Expression levels of miR-124a and miR-34a in serum were significantly lower in RA patients (median: 0.64 and 0.30, respectively) compared to controls (median: 3.12 and 1.88, respectively), P < 0.001. Their serum levels were negatively associated with disease activity and inversely correlated with DAS28, C-reactive protein, and erythrocyte sedimentation rate (P < 0.001).

Conclusion:
Serum miR-124a and miR-34a could serve as potential noninvasive biomarkers for RA diagnosis and reflect the disease activity in RA patients.
Clarification of Systemic Corticosteroid Therapy in Community-acquired Pneumonia
Authors: Hassanzad Maryam , Asi Maedeh , Valinejadi Ali , Ghaffaripour Hosseinali , Sadati Elham , Derakhshan Korosh Fakhimi , Velayati Ali Akbar 
Published: June 2024

Abstract
We received a complaint of fever and tachypnea from a 6-year-old girl who came to our hospital. She was treated for 20 days with antibiotics and corticosteroids. She was admitted for 10 days with a diagnosis of pneumonia and was discharged after the fever subsided. Two days after her discharge, the respiratory symptoms returned, and she came to us because of the severity of her symptoms. We diagnosed her with community-acquired pneumonia (CAP), performed the necessary radiographic and laboratory procedures, and the following outcomes were obtained: the computed tomography scan revealed consolidation between the right lung’s upper and middle lobes as well as an air bronchogram, but the chest ultrasound revealed no signs of pleural effusion. D-dimer, white blood cell, erythrocyte sedimentation rate, and C-reactive protein were also high in the laboratory test results, indicating pulmonary inflammation. She was finally diagnosed with CAP, and although the cause of the illness is unknown, she underwent a 14-day course of common antibiotics. Two days after the medication began, the fever subsided, and the tachypnea decreased. We believe that the corticosteroid treatment during the initial hospital stay is what caused the disease agent to persist and cause the fever to recur.
Comparative Analysis of Pooling Methods for SARS-CoV-2 Real-time Polymerase Chain Reaction Testing
Authors: Paikrao Vishwajit M. , Hassani Umesh S. , Nagdeo Neena V. 
Published: June 2024

Abstract

Background:
Wide spread coronavirus 2019 (COVID-19) infections in 2020 and 2021 and fewer real-time polymerase chain reaction (PCR) laboratories placed extraordinary demand on molecular diagnostics. To accommodate demand for increased testing volumes, the Indian Council of Medical Research had initially allowed pooling of five samples. This study aimed to conduct a comparative analysis of three sample pooling methods for SARS-CoV-2 testing to assess their effectiveness, sensitivity, and specificity.

Methods:
In this cross-sectional study, samples intended for SARS-CoV-2 testing were initially tested individually and then combined in a 1:4 positive-to-negative ratio. A total of 90 pools, comprising 450 samples, were analyzed using three distinct pooling methods: swab pooling, viral transport medium (VTM) pooling, and RNA pooling, all targeting the detection of the RdRp gene. PCR testing was conducted for all 90 pools comprising 450 samples in a uniform manner.

Results:
Swab pooling and RNA pooling methods correctly identified RdRp gene in all samples. VTM pooling method failed to identify RdRp gene in 4 samples. Analysis of cycle threshold (CT) value showed, loss of mean CT value of 2.80 ± 0.86 in swab pooling method with Z score of 6.03, VTM pooling method showed loss of mean CT value of 1.96 ± 0.76 with Z score of 3.22 and RNA pooling method showed loss of mean CT value of 1.73 ± 0.58 with Z score of 4.29 in. P value was statistically significant (<0.001) in all three methods.

Conclusion:
This study concludes that the RNA pooling method is superior, with minimal sensitivity loss in CT values. Swab pooling is cost-effective for negative pools but impractical for positive ones, while the VTM pooling method offers greater cost-effectiveness compared to RNA pooling.
Implication of Negative GeneXpert Mycobacterium tuberculosis/Rifampicin Results in Suspected Tuberculosis Patients: A Research Study
Authors: Kusumaningrum Deby , Mertaniasih Ni Made , Soedarsono Soedarsono , Setiawati Rosy , Pradipta Canti Permata 
Published: June 2024

Objective:
GeneXpert Mycobacterium tuberculosis/rifampicin (MTB/RIF) is a conceptually helpful tool for establishing tuberculosis (TB) disease. Negative results from the GeneXpert test do not exclude the possibility of diagnosing non-tuberculous mycobacteria lung disease (NTMLD) as a chronic pulmonary disease. When a patient is diagnosed on a clinical basis, and there is no bacteriological evidence of TB, it is necessary to consider NTM as one of the causes of disease with TB-like symptoms. The prevalence of non-tuberculous mycobacteria (NTM) disease is rising globally, but its diagnosis is still delayed and often misdiagnosed as multidrug-resistant TB (MDR-TB). This study highlights the implication of negative GeneXpert MTB/RIF results in suspected TB patients who conducted mycobacteria culture and detected the incidence of NTMLD.

Methods:
In this experimental study, the performance of GeneXpert MTB/RIF-negative results with those of mycobacteria cultures and lung abnormalities among suspected TB patients in a referral hospital in Indonesia were evaluated. From January to August 2022, 100 sputum samples from suspected chronic pulmonary TB patients with GeneXpert MTB/RIF assay-negative results were cultured in Lowenstein–Jensen medium, and the implication among negative GeneXpert result MTB/RIF assay.

Results:
7% were confirmed to have MTB and 1% had NTM by culture assay. Moreover, 34% were diagnosed with clinical TB and treated with anti-TB drugs.

Conclusion:
For patients with negative assay results of GeneXpert MTB/RIF regarding clinically suspected chronic TB infection, further diagnostic tests to determine the causative agents of the lung abnormalities should be carried out.
Does the prevalence of depression in patients with malignancies vary with the diagnostic approach: A study comparing the four diagnostic approaches
Authors: Mishra Eepsita , Nanjaiya Subodh Bhagyalaxmi , Ghoshal Sushmita , Grover Sandeeep 
Published: June 2024

Background:
Very few studies have compared different diagnostic approaches to diagnose depression in patients with cancers.

Aim:
To compare the different diagnostic approaches used for diagnosing depression in patients with cancers.

Methodology:
This cross-sectional study included 200 patients (diagnosed with cancer at least 3 months prior to recruitment) attending the outpatient services who were assessed on diagnostic and statistical manual, fifth edition (DSM-5) criteria for depression. Additionally, these patients were also assessed using the inclusive, exclusive, and substitutive criteria for depression using a semistructured interview. Patients completed Patient Health Questionnaire-9 (PHQ-9).

Results:
The mean age of the patients was 50.28 years (S.D. M14.11). Females outnumbered males. The mean age of onset of malignancy was 47 years (S.D 14.03), and the mean time since diagnosis of cancer was 35.45 years (S.D 36.87). The prevalence of depression was the highest (38.5%) when estimated using the PHQ-9 and was the lowest (21.5%) when assessed using exclusive criteria for depression. All approaches had high degree of concordance with the DSM–5 criteria for depression.

Conclusion:
A significant proportion of patients with cancer suffer from depression, and the prevalence is influenced by the diagnostic method.
Effectiveness and tolerability of adjunctive transcranial direct current stimulation (tDCS) in management of treatment-resistant depression: A retrospective chart review
Authors: Verma Rohit , Ganesh Ragul , Narnoli Shubham , Nandakumar Dhandapani , Sharma Panna , Sharma Kuldeep , Dhyani Ishita , Karna Stuti 
Published: June 2024

Background:
There is a limited number of studies from India investigating the role of transcranial direct current stimulation (tDCS) in treatment-resistant depression (TRD). This clinic-based study reports on the effectiveness of tDCS as an add-on treatment in individuals suffering from TRD.

Materials and Methods:
Twenty-six right-handed individuals suffering from major depressive disorder who failed to respond to adequate trials of at least two antidepressant drugs in the current episode received tDCS as an augmenting treatment. Twice daily sessions of conventional tDCS were given providing anodal stimulation at the left dorsolateral prefrontal cortex (DLPFC) and cathodal placement at the right DLPFC. A total of 20 sessions were given over 2 weeks. The outcome was assessed based on changes in scores of the Hamilton Rating Scale for Depression (HAMD) and Montgomery-Asberg Depression Rating Scale (MADRS).

Results:
There was a significant reduction in outcome assessment after tDCS intervention as compared to baseline, with more than 50% of the participants showing response in both scales, which increased further to approximately 77% by the end of 1 month of the follow-up period.

Conclusion:
Twice daily tDCS sessions with anodal stimulation of left DLPFC and cathodal stimulation of right DLPFC is an effective add-on treatment strategy in individuals with TRD.
Comparative Evaluation of the Microleakage of Self-etch Adhesives on the Pulp Chamber Dentin after Proanthocyanidin Application: An In vitro Study
Authors: Shenoy Vanitha Umesh , Chaudhari Yashaswi Rajendra , Patil Anuradha , Margasahayam Sumanthini Venkatsubramanyam , Naik Divya , Verma Jayeeta 
Published: June 2024

ABSTRACT

Background:
The long-term success of adhesive restorations is contingent on minimizing microleakage, which can lead to postoperative sensitivity and secondary caries. Sodium hypochlorite (NaOCl) and ethylenediaminetetraacetic acid (EDTA) irrigation are commonly employed during adhesive restorative procedures, but their impact on microleakage remains a concern. Proanthocyanidin (PA), a naturally derived agent, has shown potential in enhancing bond strength.

Aim:
This study aimed to compare and evaluate the effect of treatment with or without 30% PA of the pulp chamber dentin after 1% NaOCl and 17% EDTA irrigation on the microleakage of adhesive restorations.

Materials and Methods:
Forty caries-free, freshly extracted permanent human molars were used. The pulp chamber roof was removed, and the roots were resected. Canal orifices were enlarged and sealed. Specimens were divided into four groups based on adhesives (OptiBond All-In-One and Adper Easy One) and irrigation regimens. After irrigation, pulp chambers were restored with Filtek Bulk-Fill composite resin. Microleakage was assessed using methylene blue dye penetration.

Results:
Microleakage was observed in all groups, irrespective of irrigation protocol and adhesives. PA application showed reduced dye penetration compared to without PA, although not statistically significant. Statistical analysis was performed using Kruskal–Wallis and Mann–Whitney tests at P < 0.05.

Conclusion:
Irrigation protocols and the use of PA had no significant effect on the microleakage of self-etch adhesives to pulp chamber dentin. A 1-min application of 30% PA solution after NaOCl and EDTA irrigation did not improve the bonding of self-etch adhesives to pulp chamber dentin.