bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive Review of Mesoporous Silica Nanoparticles: Drug Loading, Release, and Applications as Hemostatic Agents
Authors: Albayati Talib M. , Alardhi Saja M. , Khalbas Ali H. , Humdi Zainab J. , Ali Nisreen S. , Salih Issam K. , Saady Noori M. Cata , Zendehboudi Sohrab , Abdulrahman Mahir A. 
Published: June 2024

AbstractRecently, mesoporous silica nanoparticles (MSNs) have emerged as promising candidates in the field of hemorrhage control owing to their extended pore size, high surface area, and excellent biocompatibility. These characteristics directly influence the toxicity of cells, the loading of therapeutic agents, and the release of active ions during the hemostasis process. Therefore, understanding the fundamentals of tuning these characteristics is important to design these types of carriers. While several literature reviews have explored the role of MSNs in hemorrhage control, comprehensive studies focusing on their general characteristics and specific applications remain scarce. This review concentrates on the principles of synthesizing mesoporous silica, the general types of MSNs, techniques for loading drugs methods onto the site of injury, release kinetics models, biocompatibility, toxicity, and the unique properties of MSNs. Furthermore, the article examines the mechanism of action of MSNs as nanomaterial hemostatic agents.
Kinetics of Plasticized Poly(vinyl chloride) Thermal Degradation, Induction, Autocatalysis, Glass Transition, Diffusion
Authors: Krongauz Vadim V. 
Published: June 2024

AbstractKinetics of non‐oxidative thermal degradation of poly(vinyl chloride) (PVC) plasticized with di(2‐ethylhexyl)phthalate and epoxidized linseed oil (ELO) were studied using differential scanning calorimetry. PVC thermal degradation autocatalyzed by forming HCl is delayed in the presence of acid scavenging ELO. Direct HCl elimination rates during steady state degradation (induction period) were almost independent on ELO concentration, with rate constants ranging from ≈3.2×10−6 s−1 at 463 K to ≈7.0×10−5 s−1 at 503 K. Activation energy of HCl elimination increased with glass transition temperature (Tg) increase from 136.0 kJ mol−1 at Tg=260.3 K to 141.9 kJ mol−1at Tg=274.2 K. Diffusion coefficients of HCl diffusion in plasticized PVC deduced using Williams‐Landel‐Ferry equation were of the order of 10−4 cm2 sec−1. Calculated activation energy of HCl diffusion in plasticized PVC was ≈30 kJ mol−1. The rate constants of PVC autocatalytic degradation were derived from the experimental data (for the 1st time) using Šesták‐Berggren approach and ranged from 3.2×10−2 sec−1 at 503 K to 4.4×10−3 sec−1 at 463 K. Autocatalysis activation energies ranged from 70.4 kJ mol−1 to 85.1 kJ mol−1 and increased with increase of glass transition temperature. It was established that PVC degradation kinetics was not controlled by HCl diffusion. Compensation effect was observed for initial and catalyzed PVC degradation.
Targeted Modulation of Redox and Immune Homeostasis in Acute Lung Injury Using a Thioether‐Functionalized Dendrimer
Authors: Jiang Xu‐Qin , Wang Wu‐Xuan , Dong Wang , Xie Qiu‐Meng , Liu Qian , Guo Zixuan , Chen Ning , Song Si‐Ming , Jiang Wei , Wu Hui‐Mei 
Published: June 2024

AbstractAcute lung injury (ALI) is the pathophysiological precursor of acute respiratory distress syndrome. It is characterized by increased oxidative stress and exaggerated inflammatory response that disrupts redox reactions and immune homeostasis in the lungs, thereby posing significant clinical challenges. In this study, an internally functionalized thioether‐enriched dendrimer Sr‐G4‐PEG is developed, to scavenge both proinflammatory cytokines and reactive oxygen species (ROS) and restore homeostasis during ALI treatment. The dendrimers are synthesized using an efficient and orthogonal thiol‐ene “click” chemistry approach that involves incorporating thioether moieties within the dendritic architectures to neutralize the ROS. The ROS scavenging of Sr‐G4‐PEG manifests in its capacity to sequester proinflammatory cytokines. The synergistic effects of scavenging ROS and sequestering inflammatory cytokines by Sr‐G4‐PEG contribute to redox remodeling and immune homeostasis, along with the modulation of the NLRP3‐pyroptosis pathway. Treatment with Sr‐G4‐PEG enhances the therapeutic efficacy of ALIs by alleviating alveolar bleeding, reducing inflammatory cell infiltration, and suppressing the release of inflammatory cytokines. These results suggest that Sr‐G4‐PEG is a potent nanotechnological candidate for remodeling redox and immune homeostasis in the treatment of ALIs, demonstrating the great potential of dendrimer‐based nanomedicine for the treatment of respiratory pathologies.
2D Tungsten Borides Induced Interfacial Modulation Engineering Toward High‐Rate Performance Zinc‐Iodine Battery
Authors: Zhao Yuwei , Zhang Linghai , Zheng Yunshan , Xu Huifang , Jiang Qingbin , Chen Tianyu , Hui Kwan San , Hui Kwun Nam , Wang Lin , Zha Chenyang 
Published: June 2024

AbstractAqueous zinc‐iodine batteries are promising candidates for large‐scale energy storage due to their high energy density and low cost. However, their development is hindered by several drawbacks, including zinc dendrites, anode corrosion, and the shuttle of polyiodides. Here, the design of 2D‐shaped tungsten boride nanosheets with abundant borophene subunits‐based active sites is reported to guide the (002) plane‐dominated deposition of zinc while suppressing side reactions, which facilitates interfacial nucleation and uniform growth of zinc. Meanwhile, the interfacial d‐band orbits of tungsten sites can further enhance the anchoring of polyiodides on the surface, to promote the electrocatalytic redox conversion of iodine. The resulting tungsten boride‐based I2 cathodes in zinc‐iodine cells exhibit impressive cyclic stability after 5000 cycles at 50 C, which accelerates the practical applications of zinc‐iodine batteries.
Supplemental light quality affects optimal seeding density of microgreens
Authors: de Freitas Isabela Scavacini , da Costa Mello Simone , Nemali Krishna 
Published: June 2024

AbstractHigher seeding densities can negatively affect the yield of microgreens. We quantified the effects of supplemental light quality and seeding density on the yield of microgreens. Seeds of red beet (Beta vulgaris L. ssp. esculenta) were grown in a greenhouse and provided with a narrow‐spectrum (or “purple”) and broad‐spectrum (or “white”) supplemental lighting at nighttime. Purple spectrum contained 90% red, 0% green, 10% blue, and 0% far‐red (R90: G0: B10: FR0) light, and white spectrum had 35% red, 42% green, 23% blue, and 0% far‐red light (R35: G42: B23: FR0). Each light quality treatment contained seeding densities of 50, 150, 300, and 450 g m−2. We measured fresh weight (FW) and dry weight (DW) on days 8, 10, 12, and 14 after sowing, relative growth rate (RGR), canopy area (CA), and chlorophyll (chl)a, chlb, betacyanin, and betaxanthin pigments. The optimal seeding density in the white treatment was 300 g m−2, whereas FW increased even at the seeding density of 450 g·m−2 in the purple treatment. The RGR of seedlings decreased with increasing seeding density but was higher by 27.8% in the purple than white treatment. The slope of the relationship between DW and CA (related to photosynthetic efficiency) was higher for the purple than white treatment (0.012 vs. 0.008 g cm−2). The ratio of chla to chlb (related to photosynthetic reaction center activity) increased by 15% in the purple than white treatment. Therefore, higher optimal density in the purple than white light quality treatment is likely due to increased photosynthetic efficiency of seedlings.
Missed opportunities for AI governance: lessons from ELS programs in genomics, nanotechnology, and RRI
Authors: Braun Maximilian , Müller Ruth 
Published: June 2024

AbstractSince the beginning of the current hype around Artificial Intelligence (AI), governments, research institutions, and the industry invited ethical, legal, and social sciences (ELS) scholars to research AI’s societal challenges from various disciplinary viewpoints and perspectives. This approach builds upon the tradition of supporting research on the societal aspects of emerging sciences and technologies, which started with the Ethical, Legal, and Social Implications (ELSI) Program in the Human Genome Project (HGP) in the early 1990s. However, although a diverse ELS research community has formed since then, AI’s societal challenges came to be mostly understood under the narrow framing of ethics and disconnected from the insights and experiences of past ELS research. In this article, we make up for this gap and connect insights from past ELS researchers with current approaches to research the societal challenges of AI. We analyse and summarize the history of “ELS programs” (programs that emerged since the HGP to support ELS research in a given domain) as three distinct eras: a genomics era, a nano era, and an RRI era. Each of these eras comprises several achievements and challenges relevant to ELS programs in AI research, such as the setup of independent funding bodies, the engagement of the wider public in research practice, and the increasing importance of private actors. Based on these insights, we argue that AI research currently falls back on self-regulatory, less participatory, and industry-led approaches that trouble ELS programs’ past achievements and hinder opportunities to overcome the still-existing challenges.
Photon-counting CT: technical features and clinical impact on abdominal imaging
Authors: Onishi Hiromitsu , Tsuboyama Takahiro , Nakamoto Atsushi , Ota Takashi , Fukui Hideyuki , Tatsumi Mitsuaki , Honda Toru , Kiso Kengo , Matsumoto Shohei , Kaketaka Koki , Enchi Yukihiro , Kawabata Shuichi , Nakasone Shinya , Tomiyama Noriyuki 
Published: June 2024

AbstractPhoton-counting CT has a completely different detector mechanism than conventional energy-integrating CT. In the photon-counting detector, X-rays are directly converted into electrons and received as electrical signals. Photon-counting CT provides virtual monochromatic images with a high contrast-to-noise ratio for abdominal CT imaging and may improve the ability to visualize small or low-contrast lesions. In addition, photon-counting CT may offer the possibility of reducing radiation dose. This review provides an overview of the actual clinical operation of photon-counting CT and its diagnostic utility in abdominal imaging. We also describe the clinical implications of photon-counting CT including imaging of hepatocellular carcinoma, liver metastases, hepatic steatosis, pancreatic cancer, intraductal mucinous neoplasm of the pancreas, and thrombus.
Graphical Abstract
Concept of a sensor-integrating jaw coupling for measuring operating data
Authors: Ewert Arthur , Menning Johannes D. M. , Prokopchuk Artem , Rosenlöcher Thomas , Henke E.-F. Markus , Wallmersperger Thomas , Schlecht Berthold 
Published: June 2024

AbstractIn recent years, industry and research (i) have driven the development and application of data-driven machines and systems and (ii) have increasingly introduced predictive maintenance. One of the main challenges is the acquisition of representative data for these applications. In the scope of mechanical systems, machine elements are the key parts for measuring process relevant data. Thereby, elastic couplings offer a considerable potential for a wide range of applications. The present work describes a novel space neutral sensor-integrating gear rim of a jaw coupling for the measurement of torque, rotational speed and temperature. The mechanical modifications on the coupling and the applied dielectric elastomer sensor are outlined. Additionally, the electrical conceptualization and the measurement chains are described. A manufactured prototype of the sensor-integrating jaw coupling and a proof of concept are presented.
Exploring the impact of acute viral exposure on clinical characteristics and antibody profiles in antiphospholipid syndrome: a study in CAPSTONE
Authors: Wang Chuhan , Jiang Hui , Chen Siyun , Zhao Yuan , Li Jun , Huang Can , Zhou Yangzhong , Wang Qian , Tian Xinping , Li Mengtao , Zeng Xiaofeng , Zhao Yan , Wu Chuancong , Zhao Jiuliang 
Published: June 2024

AbstractThe relationship between antiphospholipid syndrome (APS) and acute viral infection, such as SARS-CoV-2, is unclear. This study aims to assess symptoms, antiphospholipid antibody (aPL) fluctuations, and complication risks in APS patients infected with SARS-CoV-2. APS patients from Peking Union Medical College Hospital during the COVID-19 outbreak (October–December 2022) were included. Age- and gender-matched APS patients without infection served as controls. Data on demographics, symptoms, treatments, and serum aPL levels were analyzed. Of 234 APS patients, 107 (45.7%) were infected with SARS-CoV-2. Typical symptoms included high fever (81.3%), cough/expectoration (70.1%), and pharyngalgia (52.3%). Age- and gender-based matching selected 97 patients in either infected or uninfected group. After infection, anti-β-2-glycoprotein I-IgG (aβ2GP1-IgG) increased from 4.14 to 4.18 AU/ml, aβ2GP1-IgM decreased from 9.85 to 7.38 AU/ml, and anticardiolipin-IgA (aCL-IgA) significantly increased with a median remaining at 2.50 APLU/ml. Lupus anticoagulants and other aPLs remained stable. Arterial thrombosis incidence increased from 18 (18.6%) to 21 (21.6%), while venous thrombosis incidence did not change. Additionally, 7 (6.5%) patients presented either new-onset or worsening thrombocytopenia, characterized by a significant decline in platelet count (no less than 10 × 109/L) within two weeks of SARS-CoV-2 infection, all of which recovered within 2 weeks. Acute SARS-CoV-2 infection may induce or worsen thrombocytopenia but does not substantially increase thrombotic events in APS. The process of SARS-CoV-2 infection was related to mild titer fluctuation of aβ2GP1-IgG, aβ2GP1-IgM and aCL-IgA in APS patients, necessitating careful monitoring and management.
A note on the 2-colored rectilinear crossing number of random point sets in the unit square
Authors: Cabello S. , Czabarka É , Fabila-Monroy R. , Higashikawa Y. , Seidel R. , Székely L. , Tkadlec J. , Wesolek A. 
Published: June 2024

AbstractLet $$S$$
S
be a set of four points chosen independently, uniformly at random from a square. Join every pair of points of $$S$$
S
with a straight line segment. Color these edges red if they have positive slope and blue, otherwise. We show that the probability that $$S$$
S
defines a pair of crossing edges of the same color is equal to $$1/4$$

1
/
4

. This is connected to a recent result of Aichholzer et al. [1] who showed that by 2-colouring the edges of a geometric graph and counting monochromatic crossings instead of crossings, the number of crossings can be more than halved.
Our result shows that for the described random drawings, there is a coloring of the edges such that the number of monochromatic crossings is in expectation $$\frac{1}{2}-\frac{7}{50}$$

1
2

-

7
50

of the total number of crossings.
GFPT2 expression is induced by gemcitabine administration and enhances invasion by activating the hexosamine biosynthetic pathway in pancreatic cancer
Authors: Miyazaki Kent , Ariake Kyohei , Sato Satoko , Miura Takayuki , Xun Jingyu , Douchi Daisuke , Ishida Masaharu , Ohtsuka Hideo , Mizuma Masamichi , Nakagawa Kei , Kamei Takashi , Unno Michiaki 
Published: June 2024

AbstractOur previous studies revealed a novel link between gemcitabine (GEM) chemotherapy and elevated glutamine-fructose-6-phosphate transaminase 2 (GFPT2) expression in pancreatic cancer (PaCa) cells. GFPT2 is a rate-limiting enzyme in the hexosamine biosynthesis pathway (HBP). HBP can enhance metastatic potential by regulating epithelial-mesenchymal transition (EMT). The aim of this study was to further evaluate the effect of chemotherapy-induced GFPT2 expression on metastatic potential. GFPT2 expression was evaluated in a mouse xenograft model following GEM exposure and in clinical specimens of patients after chemotherapy using immunohistochemical analysis. The roles of GFPT2 in HBP activation, downstream pathways, and cellular functions in PaCa cells with regulated GFPT2 expression were investigated. GEM exposure increased GFPT2 expression in tumors resected from a mouse xenograft model and in patients treated with neoadjuvant chemotherapy (NAC). GFPT2 expression was correlated with post-operative liver metastasis after NAC. Its expression activated the HBP, promoting migration and invasion. Treatment with HBP inhibitors reversed these effects. Additionally, GFPT2 upregulated ZEB1 and vimentin expression and downregulated E-cadherin expression. GEM induction upregulated GFPT2 expression. Elevated GFPT2 levels promoted invasion by activating the HBP, suggesting the potential role of this mechanism in promoting chemotherapy-induced metastasis.
Preference for sons: still a trend? Evidence from individual-level data from Finland, 1960–2015
Authors: Riukula Krista 
Published: June 2024

AbstractPreference for sons has been shown in various ways, but is it still up to date? I investigate how sex preference has evolved during the past 50 years using population-wide data from Finland. I find that having a first-born girl increases fertility and decreases the probability of being together with the child’s father in the 1960s to 1980s but not after the 1990s. Families with a first-born girl had 0.03 more children in the years 1960–1980. The effect decreases to an imprecise zero in the 1990s and to 0.007 fewer children in the 2000s. This shift occurs at the same time as the female and male employment rates approach each other. As the costs of raising a girl are not greater than those of raising a boy in Finland, the results suggest that the shift might be due to increased female bargaining power. Past literature has shown that females prefer girls over boys or are more neutral than males, who prefer having sons over daughters more often.
Smart mandibular advancement devices for obstructive sleep apnea: a systematic literature review
Authors: Yang Joshua , Rosenmöller Boudewijn R.A.M. , van Riet Tom C.T. , Tan Misha L. , Jamaludin Faridi S. , Ho Jean-Pierre T.F. , de Lange Jan 
Published: June 2024

Abstract
Purpose
The goal of this review is to provide sleep physicians, dentists, and researchers with an evidence-based overview of the literature on smart mandibular advancement devices (MADs) for the treatment of obstructive sleep apnea.

Methods
A systematic literature search was conducted by two blinded reviewers and an information specialist. A smart MAD was defined as any MAD with additional functionality besides mandibular protrusion. The bibliographic databases Medline, Embase, and Scopus were used to identify relevant publications. Studies were included if they described any stage of development of smart MADs. A total of 3162 titles and abstracts were screened for their relevance. In total, 58 articles were selected for full-text screening, 26 of which were included in this review.

Results
The overall quality of the available literature was low. Most of the studies were observational, clinical or applied-research articles. The authors classified MADs into two main groups: passive and active. Passive MADs measured patient data, most commonly patient compliance. Active MADs adjusted protrusion of the mandible in response to patient data and were found in various phases of technological readiness (in development, demonstration, or deployment).

Conclusion
Innovations in smart mandibular advancement devices most frequently track patient compliance. Devices measuring other health parameters and active, feedback-controlled, devices are increasingly reported on. However, studies demonstrating their added benefit over traditional methods remain sparse. With further study, smart mandibular advancement devices have the potential to improve the efficiency of obstructive sleep apnea treatment and provide new treatment possibilities.
How One Cannot Participatively Imagine What One Could Cognitively Imagine
Authors: Voltolini Alberto , Barbero Carola 
Published: June 2024

AbstractIn this paper, we want to maintain that the puzzle of imaginative resistance is basically a pragmatic issue due to the failure of participative imagination, as involving a pre-semantic level relating to a wide context (the overall situation of discourse). Since the linguistic meanings of the relevant fiction-involving sentences violate some of our basic norms, what such sentences (fictionally) say cannot be participatively imagined. That failure leads one to refrain from ascribing such sentences the fictional truth-conditions they would have in narrow fictional contexts (sets of fixed parameters) as determined by those meanings in those contexts. Yet one could still make that ascription, for one can cognitively imagine what such sentences would say in those contexts. As is proved by the fact that if one either adopts an alternative view on such norms or, for some reason, brackets them, one can again perform that ascription.
Correlation of CT-based radiomics analysis with pathological cellular infiltration in fibrosing interstitial lung diseases
Authors: Haga Akira , Iwasawa Tae , Misumi Toshihiro , Okudela Koji , Oda Tsuneyuki , Kitamura Hideya , Saka Tomoki , Matsushita Shoichiro , Baba Tomohisa , Natsume-Kitatani Yayoi , Utsunomiya Daisuke , Ogura Takashi 
Published: June 2024

Abstract
Purpose
We aimed to identify computed tomography (CT) radiomics features that are associated with cellular infiltration and construct CT radiomics models predictive of cellular infiltration in patients with fibrotic ILD.

Materials and methods
CT images of patients with ILD who underwent surgical lung biopsy (SLB) were analyzed. Radiomics features were extracted using artificial intelligence-based software and PyRadiomics. We constructed a model predicting cell counts in histological specimens, and another model predicting two classifications of higher or lower cellularity. We tested these models using external validation.

Results
Overall, 100 patients (mean age: 62 ± 8.9 [standard deviation] years; 61 men) were included. The CT radiomics model used to predict cell count in 140 histological specimens predicted the actual cell count in 59 external validation specimens (root-mean-square error: 0.797). The two-classification model’s accuracy was 70% and the F1 score was 0.73 in the external validation dataset including 30 patients.

Conclusion
The CT radiomics-based model developed in this study provided useful information regarding the cellular infiltration in the ILD with good correlation with SLB specimens.