bluuebunny/crossref_metadata_2025_split huggingface dataset:
Saponification products in the process of cleaning waste water
Authors: Dordević Dani , Vítězová Monika , Vítěz Tomáš , Dordevic Simona , Hamšíková Monika , Kushkevych Ivan 
Published: May 2024

Abstract

The research work deals with the dynamics of saponification products and their interaction with microbial communities that thrive in both aerobic and anaerobic sewage sludge from wastewater treatment plants. A particular focus of this research is the potential of reutilising used cooking oils, which are normally waste, into a new product – soap. The study evaluates the efficacy of soap degradation within wastewater sludge, employing the respiration activity of microorganisms as a metric, with a specific focus on monitoring biological oxygen demand levels. Under anaerobic conditions, the degradation of soaps occurs, facilitating the generation of biofuels, notably methane, as a consequential by product of this biochemical process. The results of the study emphasise that the saponification products have no recognisable toxic effects on the microorganisms in the sewage sludge. Furthermore, the study emphasises the successful degradation of these products throughout the wastewater treatment process, confirming the biodegradation processes associated with such treatment methods. Consequently, the study emphasises the possibility of using saponification products as a valuable and economically viable resource to improve microbial respiration dynamics in wastewater treatment systems. Furthermore, their potential to increase the production of biofuels, especially methane, underlines their importance in promoting sustainable approaches to waste management and resource utilisation in the context of wastewater treatment.
Impact of the World Health Organization's Thinking Healthy Program (THP) on Maternal Depression, Lifestyle, and Delivery Method: An interventional Study in Iran
Authors: Botyar Maliheh , Moghaddam-Banaem Lida , Sadatmahalleh Shahideh Jahanian , Esmaeilinasab Maryam , Ahmadi Fazlollah 
Published: May 2024

Abstract

Background:Maternal depression during pregnancy and the postnatal period can have significant implications for both the mother and child. The Thinking Healthy Program (THP) has shown promise in addressing perinatal depression, but its impact on maternal well-being, delivery mode, and lifestyle in the Iranian context remains understudied.
Methods: This interventional study included 80 pregnant women in Tehran, Iran, divided into intervention and control groups. Depression levels were assessed using the Edinburgh and Beck questionnaires, with the intervention group receiving THP from health liaisons and the control group receiving routine care. The THP intervention comprised four modules conducted from the second trimester of pregnancy to six months post-delivery. Depression scores were evaluated at various time points, and delivery mode and health-promoting lifestyle were documented.
Results: At the end of pregnancy (first module), Edinburgh scores were 12.3±2.2 vs.15.81±2, and the Beck scores were 19±4 vs. 20±4 in the intervention and control groups respectively. At the end of the study, 6 months after birth, Beck scores were 9±4.3 vs. 10.6±3.3 in the intervention and control groups, respectively (all P-values<0.001). At all end points, depression scores were more improved in the intervention group. The lifestyle score at the end of the study was significantly higher in the intervention group (151±17 vs. 107±12) (P<0.001). Also, elective caesarean section was significantly lower in the intervention group (10% vs. 57.5%) (P-value: 0.001).
Discution: The implementation of THP in this study led to improved maternal well-being, as evidenced by reduced depression symptoms, positive impacts on lifestyle, and a lower rate of elective caesarean sections.
Conclusion:
These findings suggest the feasibility and benefits of integrating THP into the Iranian healthcare system to support pregnant women with depression and enhance maternal and child health outcomes.
Enhancing autologous Equine Therapy: Innovative 3D Culture Method for Muscle-derived Progenitor Cells (mdP-Cells)
Authors: Graide H. , Duysens J. , Franck T. , Mouithys-Mickalad A. , Niesten A. , Sandersen Charlotte , Ceusters J. , Serteyn D. 
Published: May 2024

Abstract

Musculoskeletal pathologies pose significant challenges in athletic horses, often leading to loss of function. The limited healing capacity of bone, joint, and tendon/ligament injuries, combined with the inefficacy of conventional treatments, underscores the need for innovative therapeutic strategies such as Mesenchymal Stem/Stroma Cells (MSCs). Conventional cell culture methods typically employ two-dimensional (2D) culture systems with adherent cells using fetal bovine serum. However, three-dimensional (3D) cell culture offers a more physiologically relevant milieu, closely resembling native tissue architecture and in vivo cell-cell interactions. This study introduces a novel approach for isolating muscle-derived progenitor cells in a 3D environment, utilizing an autologous plasma-based gel and an innovative cell retrieval solution. The muscle-derived progenitor cells cultured using this method exhibited immunomodulatory properties on lymphocyte T and trilineage differentiation and immunophenotyping akin to traditional MSCs. This simplified 3D culture technique holds promise for generating minimally manipulated autologous cell products tailored for musculoskeletal applications.
Isolation and characterization of renal protective compound from the leaves of the traditionally used medicinal plant Orthosiphon stamineus Benth
Authors: Natarajan venkatesan 
Published: May 2024

Abstract

Background: Around the world medicinal plants are a natural source of medications. They are essential to both conventional therapy and traditional medicine. In India, southern China, Malaysia, and Thailand, Orthosiphon stamineus Benth. is a traditional medication used to treat diabetes and chronic renal failure. This investigation aims to evaluate the nephroprotective properties of a compound that originates from an effective ethanolic extract of Orthosiphon stamineus. Methods: The renal protective effect of the extracts and the isolated compound was assessed using the HFD and STZ induced diabetes method and subjected to TLC, column, 1H-NMR, 13C-NMR, IR, and MS to characterize the isolated compound.
Results: An ethanol extract was found to lower the BUN and creatinine levels significantly (P < 0.05) in diabetic rats. Isolated compound (OS-1) caused a significant (P< 0.05) reduction in blood BUN nitrogen and creatinine levels, and additionally, it caused a reduction in blood glucose and cholesterol levels in nephritic rats.
Conclusion: The present study results reveal that tested plant extracts have potent renal protective effects due to the occurrence of phenols, flavonoids, and anthraquinones in the extract. Reduction in BUN, creatinine, blood glucose and cholesterol by an isolated compound (OS-1) indicates that OS-1 has renal protective activity, along with hypoglycemic and hypolipidemic potential, and provides a scientific rationale for its use as a renal protective agent.
The phenomenon of drought in Ethiopia: Historical evolution and climatic forcing
Authors: Mulualem Getachew Mehabie , Raju U. Jaya Parakash , Stojanovic Milica , Sorí Rogert 
Published: May 2024

ABSTRACT

This study examines drought patterns in Ethiopia's 12 major river basins from 1981 to 2018 using the Standardized Precipitation Index (SPI) and the Standardized Precipitation Evapotranspiration Index (SPEI). Both indices reveal historical drought episodes with slight variations, with significant differences in 1984, 2009, and 2015. Except for the Wabi-Shebelle catchment in southern Ethiopia, all river basins show an increasing trend in SPI12 and SPEI12 indices. The eastern and central regions experience more drought according to SPEI3. Seasonal correlations show that during the March–May rainy season, precipitation is negatively correlated with the Indian Ocean Dipole (IOD) index, while in the June–September season, it negatively correlates with Nino 3.4 and positively with IOD. The study also found that El Niño leads to less rainfall in the Ethiopian highlands, while La Niña results in more rainfall in the central and northern highlands but less in the south.
Technology for designing structural-mental schemes for calculation tasks
Authors: Pak N. I. , Asaulenko E. V. 
Published: May 2024

The purpose of the study. Modern teaching tools and methods, as a rule, implicitly rely on the “black box” model. In contrast, the “white box” model has clear didactic advantages. Unfortunately, they are difficult to implement in the educational process due to the lack of available ways to construct this model. The purpose of the study is to develop a technology for constructing a “white box” model in the form of a structural and mental scheme of calculation tasks in the field of elementary physics. This technology involves the use of calculation primitives to design task schemes by superposition.Materials and methods. Development of technology for constructing the “white box” model in the form of a structural and mental scheme of calculation tasks in the field of elementary physics. The use of calculation primitives to construct task schemes by superposition. Determining the complexity of a specific task through the number of primitives involved in the “route” of the solution. Organization of students’ training according to the “white box” model with visualization of the process of forming skills to solve calculation tasks.Results. Schemes have the ability to ensure the strength and completeness of the formation of the ability to solve problems of the student. At the same time, the variety of routes and the set of weights of the paths make up the information model of learning. As an example, structural and mental schemes on the topic “thermal phenomena” are presented. They show the need to use several types of primitives, in particular, function primitives, sum primitives. Structural and mental schemes allow students to organize training according to the “white box” model, visualize the process of formation and development of students’ skills to solve calculation tasks, thereby ensuring control and self-control of educational activities.Conclusion. Based on the provisions of the mental approach, a technology for constructing structural and mental schemes representing a cognitive way of thinking in solving computational problems is proposed. The basic technology is computational primitives, with the help of which problem schemes are constructed by superposition. The complexity of a particular task is determined by the number of primitives involved in the “route” of the solution. The proposed technology is applicable to the construction of structural and mental schemes of computational problems in various subject areas.
New Carbothioamide and Carboxamide Derivatives of 3-Phenoxybenzoic Acid as Potent VEGFR-2 Inhibitors: Synthesis, Molecular Docking, and Cytotoxicity Assessment
Authors: Heriz Mohammad Hamza , Razzak Mahmood Ammar A. , Tahtamouni Lubna H. , Al-Sakhen Mai F. , Kanaan Sana I. , Saleh Khaled M. , Yasin Salem R. 
Published: May 2024

Introduction/Background:
Because of the well-established link between angiogenesis
and tumor development, the use of antiangiogenic therapeutics, such as those targeting VEGFR-2,
presents a promising approach to cancer treatment. In the current study, a set of five hydrazine-1-
carbothioamide (compounds 3a-e) and three hydrazine-1-carboxamide derivatives (compounds
4a-c) were successfully synthesized from 3-phenoxybenzoic acid. These compounds were specially
created as antiproliferative agents with the goal of targeting cancer cells by inhibiting VEGFR-
2 tyrosine kinase.

Materials and Methods:
The new derivatives were synthesized by conventional organic methods,
and their structure was versified by IR, 1HNMR, 13CNMR, and mass spectroscopy. In silico investigation
was carried out to identify the compounds’ target, molecular similarity, ADMET, and toxicity
profile. The cytotoxic activity of the prepared compounds was evaluated in vitro against three
human cancer cell lines (DLD1 colorectal adenocarcinoma, HeLa cervical cancer, and HepG2 hepatocellular
carcinoma). The effects of the leading compound on cell cycle progression and apoptosis
induction were investigated by flow cytometry, and the specific apoptotic pathway triggered
by the treatment was evaluated by RT-PCR and immunoblotting. Finally, the inhibitory activities
of the new compounds against VEGFR-2 was measured.

Results:
The designed derivatives exhibited comparable binding positions and interactions to the
VEGFR-2 binding site to that of sorafenib (a standard VEGFR-2 tyrosine kinase inhibitor), as determined
by molecular docking analysis. Compound 4b was the most cytotoxic compound, achieving
the lowest IC50 against HeLa cells. Compound 4b, a strong representative of the synthesized series,
induced cell cycle arrest at the G2/M phase, increased the proportion of necrotic and apoptotic
HeLa cells, and activated caspase 3. The EC50 value of compound 4b against VEGFR-2 kinase
activity was comparable to sorafenib’s.

Conclusion:
Overall, the findings suggest that compound 4b has a promising future as a starting
point for the development of new anticancer drugs.
Challenges in Distinguishing Rectal Leiomyosarcoma from Ovarian Malignancy: A Diagnostic Conundrum
Authors: Kumar Naina , Srirambhatla Annapurna , Shetty Aparna , Mangla Mishu , Roy Subhrajyoti 
Published: May 2024

Introduction:
Rectal leiomyosarcoma is a rare malignant mesenchymal tumor accounting
for <0.1% of all malignant colorectal neoplasms and carries a grave prognosis.

Case Presentation:
A 50-year-old postmenopausal, P3L3 woman presented with complaints of abdominal
pain for two months, dark-colored loose stools, 10-15 episodes per day for 2-3 months, and
gradual weight loss for 4-5 months. On ultrasonography and MRI of the pelvis, a large irregular lobulated
ill-defined solid lesion was seen arising from the right side of the pelvis measuring 14x8x14cm.
The right ovary was not observed to be separate from the mass. There was omental thickening and
peritoneal deposits with ascites. The final impression suggested a right-sided malignant ovarian mass
with peritoneal dissemination (ORADS-5) with a differential leiomyosarcoma. Her tumor markers (CA-
125; CA19-9, and CEA) were raised. Given the strong dilemma between ovarian malignancy and leiomyosarcoma
and the advanced stage of the disease, the patient was planned for an ultrasound-guided
biopsy of the lesion. The histopathological report revealed atypical spindle cell proliferation with myoid
features with the presence of multiple mitotic figures. The diagnosis of rectal leiomyosarcoma was further
confirmed with immunohistochemical tests, which were positive for actin and desmin and negative
for CD 117 and S100. The patient was referred to oncosurgeon for further management and was
planned for surgical resection followed by chemotherapy with intravenous doxorubicin.

Conclusion:
Rectal leiomyosarcoma is commonly misdiagnosed as ovarian malignancy because of
its exophytic growth and similar clinical features at the time of the presentation. Hence, clinicians
must be aware of these differentials for the successful management of cases.
Деятельность пятого настоятеля Агинского дацана Галсан-Жимбы Тугулдурова (1817–1872/3)
Authors:   Institute for Mongolian, Buddhist and Tibetan Studies of the Siberian Branch of the RAS (6, Sakhyanova St., 670047 Ulan-Ude, Russian Federation), Bukhogolova Sayana B. , Batomunkueva Soelma R. , Garmaeva Snezhana P. 
Published: May 2024

Introduction. The article examines the biography and works of the 5th abbot of Aginsky datsan (Dechen Lhundublin) Galsan Zhimba Tuguldurov. The relevance of the study is determined by importance of the personality of G.-Zh. Tuguldurov. He was one of the most significant Buryat Buddhist leaders of the 19th century. Tuguldurov was one of the bright representatives of the Buryat priesthood, expert in Buddhist philosophy, astrology, medicine and lexicology (he compiled the first Buryat Tibetan-Mongolian dictionary Despite the weight of his multifaceted personality and the presence of works reflecting his activities, the information about the details of G. Tuguldurov's biography and writings continues to remain little known. The purpose of the article is to provide historiographic overview of researches on his biography and creative heritage, introduce some new information into scientific circulation. This information was obtained from archive documents written in Old Mongolic script from the preliminary translation of not studied before biography (namthar) of G.-Zh. Tuguldurov in Tibetan language. The title of the namthar is “The biography of Galsan-Zhimba Balzangpo — the abbot of the datsan Dechen Lhundubling (bde chen lhun grub gling gi khri pa chos rje skal bzang spyin pa dpal bzang po’i rnam thar gyi sa bon bzhugs)”. Materials and methods. The research is based on the works of Russian and Mongolian authors written in different times, archival data from funds of the State Archive of the Republic of Buryatia, Center of Oriental Manuscripts and Xylographs of the Institute for Mongolian, Buddhist and Tibetan studies of the SB RAS and namthar of G.-Zh. Tuguldurov in Tibetan language (archive of Aginsky datsan). The following methods were used: collection, analysis and processing of data, historical-systematic and retrospective analysis. The results of the research helped to restore the chronology of activities of G.-Zh. Tuguldurov. For the first time the biography of G.-Zh. Tuguldurov with additional and clarifying information has been put into scientific circulation. Therefore, the restored biography of G.-Zh. Tuguldurov can make a significant contribution into academic researches, especially into reconstruction of the spread of Buddhism in the region.
Manajemen Penyelenggaraan Bimbingan Manasik Haji Lansia di Kementerian Agama Kabupaten Klaten Tahun 2023
Authors: Ikhsan Muhammad Taufik Nur , Amin Juhdi 
Published: May 2024

Penelitian ini mengkaji tentang bimbingan manasik haji lansia di Kementerian Agama Kabupaten Klaten tahun 2023. Penelitian ini bertujuan untuk mengetahui penyelenggaraan bimbingan manasik haji lansia di Kementerian Agama Kabupaten Klaten pada tahun 2023 dan faktor pendukung serta penghambatnya. Jenis penelitian ini adalah penelitian lapangan (field research) dan metode yang digunakan dalam penelitian ini adalah kualitatif deskriptif. Hasil penelitian ini menunjukkan manajemen penyelengaraan bimbingan manasik haji di Kementerian Agama Kabupaten Klaten pada tahun 2023 sudah baik dengan menjalankan tugas berdasarkan fungsi manajemen yang meliputi perencanan, pengorganisasian, penggerakkan, pengawasan. Faktor pendukung penyelengagaraan bimbingan manasik haji meliputi sumber daya manusia yang baik dan kerjasama dengan beberapa pihak. Sedangkan untuk faktor penghambatnya yaitu pendataan jamaah karena waktu pelunasan yang diundur dan latar belakang jamaah haji yang berbeda.
Understanding the Dynamics of Unemployment and Poverty in the Tomini Bay Area
Authors: Dai Sri Indriyani S. , Hasan Sherina , Setiawan Widy 
Published: May 2024

This study aims to analyze the effect of education level, gini ratio and labor force participation rate on unemployment, as well as the effect of unemployment on poverty in the Tomini Bay region. The data used in the study is secondary data in the form of 10 regencies/cities in the Tomini Bay area, for the 2018-2022 period, sourced from the Indonesian Central Bureau of Statistics. The novelty of this study is trying to trace the relationship between educational and economic aspects to the phenomenon of poverty in the Tomini Bay Region, as a regional economic power. The future impact of this study is the mapping of the actual condition of poverty and the availability of more evidence-based policy recommendations in reducing unemployment and poverty in the Tomini Bay Area. This study used descriptive quantitative methods. With an approach (Simultaneous equation regression model) using the Indirect Least Square (ILS) regression technique with Fixed Effect Model (FEM). The results of this study show that the level of education and the labor force participation rate have a negative and significant effect on unemployment. In contrast to the Gini ratio which actually has a positive and significant effect on unemployment. On the other hand, unemployment shows a positive and significant influence on poverty. The implication of the research is the need for a truly massive policy to strengthen the education dimension, to accelerate the increase in human capital and the importance of a sustainable program to increase employment opportunities from the government so as to reduce unemployment and poverty.
RANCANGAN TAMPILAN HOLOGRAFIK MUSEUM MENGGUNAKAN TEKNOLOGI 3D HOLOGRAM : STUDI KASUS PEMBANGUNAN IKN TAHAP I
Authors: Yendra Sasferi , Ngabito Olivia Febrianty , M Fulkha Tajri 
Published: May 2024

Hasil dari penelitian ini salah satu bentuk Teknik interaksi yang menjadi alat penting dalam desain pameran untuk meningkatkan partisipasi pengunjung melalui visual yang menarik. Target khusus ialah hadirnya display system menggunakan alat 3D holografik LED dengan sudut pandang 360 derajat,. untuk virtual artefak 3D dikemas dengan menggunakan metode kipas LED hologram yang dapat menvisualisasikan sebuah produk atau material melalui rotasi cahaya lampu LED, yang dihasilkan dari kumpulan kisi cahaya dan melalui proses di sebuah software (Perangkat Lunak) yang dapat di akses PC maupun iOS, serta terkoneksi langsung pada kipas LED dengan teknologi wifi. Melelui software ini, pengguna dapat menampilkan konten yang akan ditampilkan pada alat hologram. Setiap LED pada setiap sisi kipas akan segera membuat kisi cahaya sesuai dengan konten yang di unggah. Kemudian, setiap titik- titik dari kisi tersebut berubah menjadi video/ gambar yang terlihat melalui rotasi LED, sehingga terlihat efek holografik di udara. Setiap materi atau konten kreatif yang akan diputar, disimpan di ruang penyimpanan alat melalui jalur dan metode tranmisi yang berbeda-beda. Museum selayaknya menjadi ruang yang interaktif dan muncul dalam berbagai aliran dengan menggabungkan karya seni collaborasi dengan digital adalah masalah yang patut dipertimbangkan saat ini.
VIDEO ANIMASI PEMBUATAN KAIN PERCA UNTUK TUNA WICARA DENGAN TEKNIK SINGLE SHOT MEDIUM CLOSE UP
Authors: Kabelen Nicholaus Wayong 
Published: May 2024

Bahasa isyarat merupakan alat terpenting bagi penyandang disabilitas pendengaran dan bicara untuk berkomunikasi dengan orang di sekitarnya. Namun keberadaan bahasa isyarat kurang dipahami oleh masyarakat umum sehingga seringkali membatasi kebebasan bergerak para penyandang tunarungu dan tuna wicara. Anda memerlukan pendamping yang mampu menerjemahkan informasi di sekitar Anda, seperti ahli bahasa isyarat. Diperlukan inovasi-inovasi baru, khususnya di bidang teknologi, untuk membantu penyandang disabilitas pendengaran dan bicara berkomunikasi lebih nyaman dengan lingkungan sekitarnya. Secara khusus, penelitian ini memperkenalkan konsep pembuatan video animasi dalam bahasa isyarat, yang mengubah gerakan tubuh para ahli menjadi animasi 3D. Dalam ilmu videografi berbagai macam angle serta sudut pengembilan angle sangat diperlukan, namun seorang animator harus bisa menganalisa serta menentukan shot apa saja yang paling efektif dalam penerapann Bahasa isyarat agar menciptakan pergerakan animasi yang bisa diterima runa wicara.