bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined contraceptive ring versus combined oral contraceptive (30‐μg ethinylestradiol and 3‐mg drospirenone)
Authors: Mohamed Ahmed M.M. , El‐Sherbiny Wael S.M. , Mostafa Walaa A.I. 
Published: June 2011

AbstractObjectivesTo compare the adverse effects, cycle control, and metabolic effects of NuvaRing and a combined oral contraceptive (COC).MethodsWomen seeking contraception received NuvaRing (n = 300) or a COC (n = 300) for 12 cycles in a randomized, open‐label trial.ResultsThe total number of women with adverse effects did not differ significantly between the 2 groups. Leucorrhea, vaginitis, decreased libido, and ring‐related problems were more common with NuvaRing, whereas weight increase, acne, and emotional lability were more common with the COC. Breakthrough bleeding occurred in 11.3% of women receiving NuvaRing and in 14.7% of women receiving the COC; 2.1% and 2.9% of women, respectively, had no withdrawal bleeding. Differences in blood pressure, blood sugar levels, lipid profile, liver enzyme activity, and anticoagulant activity were not statistically significant, with the exception of low‐density lipoprotein levels measured at 6 and 12 months, which were significantly lower in the NuvaRing group than in the COC group.ConclusionsNuvaRing is a good alternative to a COC. It is associated with a slightly reduced incidence of breakthrough bleeding and there were no clinically relevant adverse effects or changes in blood pressure, blood sugar levels, lipid profile, or anticoagulant activity when compared with the COC.
Stem Cells for Central Nervous System Repair and Rehabilitation
Authors: Ritfeld Gaby J. , Roos Raymund A.C. , Oudega Martin 
Published: June 2011

AbstractThe central nervous system (CNS) has limited capacity for self‐repair. Current treatments are often incapable of reversing the debilitating effects of CNS diseases that result in permanent and/or progressive physical and cognitive impairments. One promising repair strategy is transplantation of stem cells, which can potentially replace lost neurons and/or glia or promote repair through secretion of trophic factors. Various types of stem cells exist, each with their own advantages and disadvantages. Although no consensus exists regarding the optimal cell type to use, moderate functional improvements have been shown in animal models of CNS diseases using different types of stem cells. However, the precise mechanism of action behind their beneficial effects remains unknown. In addition, many barriers to clinical use still need to be resolved before transplantation of stem cells can be used as effective biologics. These barriers include—depending on the stem cell type—possible tumor formation, difficulty with harvest, limited in vivo differentiation and integration, and ethical issues regarding use.
Progesterone and Vitamin D Hormone as a Biologic Treatment of Traumatic Brain Injury in the Aged
Authors: Stein Donald G. , Cekic Milos M. 
Published: June 2011

AbstractThere is growing recognition that traumatic brain injury is a highly variable and complex systemic disorder that is refractory to therapies that target individual mechanisms. It is even more complex in elderly persons, in whom frailty, previous comorbidities, altered metabolism, and a long history of medication use are likely to complicate the secondary effects of brain trauma. Progesterone, one of the few neuroprotective agents that has shown promise for the treatment of acute brain injury, is now in national and international phase 3 multicenter trials. New findings show that vitamin D hormone (VDH) and VDH deficiency in the aging process (and across the developmental spectrum) may interact with progesterone and treatment for traumatic brain injury. In this article we review the use of progesterone and VDH as biologics‐based therapies along with recent studies demonstrating that the combination of progesterone and VDH may promote better functional outcomes than either treatment independently.
Post-collisional polycyclic plutonism from the Zagros hinterland: the Shaivar Dagh plutonic complex, Alborz belt, Iran
Authors: AGHAZADEH MEHRAJ , CASTRO ANTONIO , BADRZADEH ZAHRA , VOGT KATHARINA 
Published: June 2011

AbstractThe petrological and geochronological study of the Cenozoic Shaivar Dagh composite intrusion in the Alborz Mountain belt (NW Iran) reveals important clues to decipher complex relations between magmatic and tectonic processes in the central sectors of the Tethyan (Alpine–Himalayan) orogenic belt. This pluton is formed by intrusion at different times of two main magmatic cycles. The older (Cycle 1) is formed by calc-alkaline silicic rocks, which range in composition from diorites to granodiorites and biotite granites, with abundant mafic microgranular enclaves. The younger cycle (Cycle 2) is formed by K-rich monzodiorite and monzonite of marked shoshonitic affinity. The latter form the larger volumes of the exposed plutonic rocks in the studied complex. Zircon geochronology (laser ablation ICP-MS analyses) gives a concordia age of 30.8 ± 2.1 Ma for the calc-alkaline rocks (Cycle 1) and a range from 23.3 ± 0.5 to 25.1 ± 0.9 Ma for the shoshonitic association (Cycle 2). Major and trace element relations strongly support distinct origins for each magmatic cycle. Rocks of Cycle 1 have all the characteristic features of active continental margins. Shoshonitic rocks (Cycle 2) define two continuous fractionation trends: one departing from a K-rich basaltic composition and the other from an intermediate, K-rich composition. A metasomatized-mantle origin for the two shoshonitic series of Cycle 2 is proposed on the basis of comparisons with experimental data. The origin of the calc-alkaline series is more controversial but it can be attributed to processes in the suprasubduction mantle wedge related to the incorporation of subducted mélanges in the form of silicic cold plumes. A time sequence can be established for the processes responsible of the generation of the two magmatic cycles: first a calc-alkaline cycle typical of active continental margins, and second a K-rich cycle formed by monzonites and monzodiorites. This sequence precludes the younger potassic magmas as precursors of the older calc-alkaline series. By contrast, the older calc-alkaline magmas may represent the metasomatic agents that modified the mantle wedge during the last stages of subduction and cooked a fertile mantle region for late potassic magmatism after continental collision.
Abortion and Moral Risk
Authors: Moller D. 
Published: June 2011

AbstractIt is natural for those with permissive attitudes toward abortion to suppose that, if they have examined all of the arguments they know against abortion and have concluded that they fail, their moral deliberations are at an end. Surprisingly, this is not the case, as I argue. This is because the mere risk that one of those arguments succeeds can generate a moral reason that counts against the act. If this is so, then liberals may be mistaken about the morality of abortion. However, conservatives who claim that considerations of risk rule out abortion in general are mistaken as well. Instead, risk-based considerations generate an important but not necessarily decisive reason to avoid abortion. The more general issue that emerges is how to accommodate fallibilism about practical judgment in our decision-making.
Indonesia's Postcolonial Regional Imaginary: From a ‘Neutralist’ to an ‘All-Directions’ Foreign Policy
Authors: CLARK MARSHALL 
Published: June 2011

AbstractThis paper will examine the various ways in which the regional imaginary has been conceptualized and developed in maritime Southeast Asia, primarily focussing on Indonesia. Utilizing the recent debate on the notion of a ‘Postcolonial International Relations,’ this paper examines the role of imperialism and the colonial experience on the development of Indonesian ‘ideas’ of region and regionalism. This paper is structured into four sections. First of all, it explores the link between postcolonial theory and regionalism studies. Second, it takes into account early ideas of regionalism in the post-independence era. This includes President Sukarno's ‘neutralist’ foreign policy culminating in Indonesia's hosting of the Bandung Conference as well as President Suharto's endorsement of ASEAN. The third and final section examines Indonesia's foreign policy orientation and practices in the post-authoritarian period, particularly under President Susilo Bambang Yudhoyono. With its embrace of democracy in the post-New Order era, the concluding discussion suggests that Indonesia appears to be increasingly prepared to expand its regional engagement concentrically beyond the immediate Southeast Asian region. The question of the ‘imperial’ role of the US – which has its own foreign policy ambitions in the region – is instrumental in this regard, and can be usefully understood from a postcolonial framework.
Hypoxic exercise training promotes antitumour cytotoxicity of natural killer cells in young men
Authors: Wang Jong-Shyan , Weng Tzu-Pin 
Published: June 2011

The cytotoxic functions of NKs (natural killer cells) are critical in enabling the immune system to cope efficiently with malignancy. In the present study, we compared how various exercise regimens without/with hypoxia influence phenotypic characteristics of NK subsets and cytotoxicity of NKs to NPCs (nasopharyngeal carcinoma cells). A total of 60 sedentary males were randomly divided into five groups. Each group (n=12) underwent one of five regimens: normoxic (21% O2) control (N-C), hypoxic (15% O2) control (H-C), normoxic exercise (50% maximal work rate under 21% O2; N-E), hypoxic relative exercise (50% maximal heart rate reserve under 15% O2; H-RE) or hypoxic absolute exercise (50% maximal work rate under 15% O2; H-AE) for 30 min/day, 5 days/week for 4 weeks. The results showed that hypoxic exercise regimens increased pulmonary ventilation and tissue oxygen utilization. Moreover, the H-RE regimen resulted in enhanced aerobic fitness at a less intensive training workload in the H-AE regimen. Before each regimen, strenuous exercise elevated NK perforin/granzyme B content and promoted cytotoxicity of NKs to NPCs. However, the percentage of NKs expressing homing (CD11a)/terminally differentiated (CD57)/inhibitory [KLRG1 (killer cell lectin-like receptor G1)] molecules that entered the bloodstream from peripheral tissues increased following this exercise. After 4 weeks, both the H-AE and H-RE regimens produced an up-regulated expression of memory (CD45RO)/activating (NKG2D) molecules and was accompanied by a decrease in CD57/KLRG1 levels on NKs at rest and after strenuous exercise. Furthermore, the two regimens increased resting and exercise NK perforin/granzyme B content and NK-induced phosphatidylserine exposure of NPCs. In contrast, no significant change in the phenotypic characteristics of blood NK subsets or NK-induced NPC apoptosis was observed in the N-C, H-C and N-E regimens. Therefore we conclude that 15% O2 exercise training reduces terminally differentiated NK subsets and up-regulates the expression of activating molecules and cytotoxic granule proteins in NKs, thereby enhancing the capacity of anti-NPC cytotoxicity by NKs. These findings could help to determine effective hypoxic exercise regimens for improving individual aerobic capacity and simultaneously promoting the natural cytotoxicity of NKs.
Direct visualization of myosin-binding protein C bridging myosin and actin filaments in intact muscle
Authors: Luther Pradeep K. , Winkler Hanspeter , Taylor Kenneth , Zoghbi Maria E. , Craig Roger , Padrón Raúl , Squire John M. , Liu Jun 
Published: June 2011

Myosin-binding protein C (MyBP-C) is a thick filament protein playing an essential role in muscle contraction, and MyBP-C mutations cause heart and skeletal muscle disease in millions worldwide. Despite its discovery 40 y ago, the mechanism of MyBP-C function remains unknown. In vitro studies suggest that MyBP-C could regulate contraction in a unique way—by bridging thick and thin filaments—but there has been no evidence for this in vivo. Here we use electron tomography of exceptionally well preserved muscle to demonstrate that MyBP-C does indeed bind to actin in intact muscle. This binding implies a physical mechanism for communicating the relative sliding between thick and thin filaments that does not involve myosin and which could modulate the contractile process.
Assessing the Diagnostic Accuracy of Pulse Pressure Variations for the Prediction of Fluid Responsiveness
Authors: Cannesson Maxime , Le Manach Yannick , Hofer Christoph K. , Goarin Jean Pierre , Lehot Jean-Jacques , Vallet Benoît , Tavernier Benoît 
Published: June 2011

Background
Respiratory arterial pulse pressure variations (PPV) are the best predictors of fluid responsiveness in mechanically ventilated patients during general anesthesia. However, previous studies were performed in a small number of patients and determined a single cutoff point to make clinical discrimination. The authors sought to test the predictive value of PPV in a large, multicenter study and to express it using a gray zone approach.

Methods
The authors studied 413 patients during general anesthesia and mechanical ventilation in four centers. PPV, central venous pressure, and cardiac output were recorded before and after volume expansion (VE). Response to VE was defined as more than 15% increase in cardiac output after VE. The following approaches were used to determine the gray zones: resampled and two-graph receiver operator characteristic curves. The impact of changes in the benefit-risk balance of VE on the gray zone was also evaluated.

Results
The authors observed 209 responders (51%) and 204 nonresponders (49%) to VE. The area under receiver operating characteristic curve was 0.89 (95% CI: 0.86-0.92) for PPV, compared with 0.57 (95% CI: 0.54-0.59) for central venous pressure (P < 10). The gray zone approach identified a range of PPV values (between 9% and 13%) for which fluid responsiveness could not be predicted reliably. These PPV values were seen in 98 (24%) patients. Changes in the cost ratio of VE moderately affected the gray zone limits.

Conclusion
Despite a strong predictive value, PPV may be inconclusive (between 9% and 13%) in approximately 25% of patients during general anesthesia.
Inflammatory biomarkers and prediction for intensive care unit admission in severe community-acquired pneumonia*
Authors: Ramírez Paula , Ferrer Miquel , Martí Verónica , Reyes Soledad , Martínez Raquel , Menéndez Rosario , Ewig Santiago , Torres Antoni 
Published: June 2011

Objective:
Increased inflammatory response is related to severity and outcome in community-acquired pneumonia, but the role of inflammatory biomarkers in deciding intensive care unit admission is unknown. We assessed the relationship between inflammatory response, prediction for intensive care unit admission, delayed intensive care unit admission, and outcome in patients with community-acquired pneumonia.

Design:
Prospective clinical study.

Setting:
Intensive care units of two university hospitals.

Patients:
We included 627 ward and 58 intensive care unit patients with community-acquired pneumonia, 36 with direct and 22 with delayed intensive care unit admission.

Interventions:
Serum levels of C-reactive protein, procalcitonin, tumor necrosis factor-α, interleukin-1, interleukin-6, interleukin-8, and interleukin-10 at admission.

Measurements and Main Results:
We assessed the prediction for intensive care unit admission of biomarkers and the Infectious Diseases Society of America/American Thoracic Society guidelines minor criteria for severe community-acquired pneumonia. Procalcitonin (p = .001), C-reactive protein (p = .005), tumor necrosis factor-α (p = .042), and interleukin-6 (p = .003) levels were higher in intensive care unit-admitted patients; however, the Infectious Diseases Society of America/American Thoracic Society guidelines minor severity criteria predicted better intensive care unit admission (odds ratio, 12.03; 95% confidence interval, 5.13–28.20; p < .001). No patient with severe community-acquired pneumonia by three or more minor severity criteria and procalcitonin levels below the optimal cutoff (0.35 ng/mL) needed intensive care unit admission compared with 14 (23%) with levels above the cutoff (p = .032). In patients initially admitted to wards, procalcitonin (p = .012) and C-reactive protein (p = .039) were higher in those 22 patients subsequently transferred to the intensive care unit after adjusting for age, comorbidities, and Pneumonia Severity Index risk class. Despite initially admitted to wards, 14 (64%) patients with delayed intensive care unit admission had already criteria for severe community-acquired pneumonia at admission compared with 73 (12%) ward patients (p < .001).

Conclusion:
Inflammatory biomarkers identified patients needing intensive care unit admission, including those with delayed intensive care unit admission. Patients with severe community-acquired pneumonia by minor criteria and low levels of procalcitonin may be safely admitted to wards. Correctly applying the Infectious Diseases Society of America/American Thoracic Society guidelines would reduce substantially delayed intensive care unit admission.
TheCOP1OrthologPPSRegulates the Juvenile–Adult and Vegetative–Reproductive Phase Changes in Rice
Authors: Tanaka Nobuhiro , Itoh Hironori , Sentoku Naoki , Kojima Mikiko , Sakakibara Hitoshi , Izawa Takeshi , Itoh Jun-Ichi , Nagato Yasuo 
Published: June 2011

AbstractBecause plant reproductive development occurs only in adult plants, the juvenile-to-adult phase change is an indispensable part of the plant life cycle. We identified two allelic mutants, peter pan syndrome-1 (pps-1) and pps-2, that prolong the juvenile phase in rice (Oryza sativa) and showed that rice PPS is an ortholog of Arabidopsis thaliana CONSTITUTIVE PHOTOMORPHOGENIC1. The pps-1 mutant exhibits delayed expression of miR156 and miR172 and the suppression of GA biosynthetic genes, reducing the GA3 content in this mutant. In spite of its prolonged juvenile phase, the pps-1 mutant flowers early, and this is associated with derepression of RAP1B expression in pps-1 plants independently of the Hd1-Hd3a/RFT1 photoperiodic pathway. PPS is strongly expressed in the fourth and fifth leaves, suggesting that it regulates the onset of the adult phase downstream of MORI1 and upstream of miR156 and miR172. Its ability to regulate the vegetative phase change and the time of flowering suggests that rice PPS acquired novel functions during the evolution of rice/monocots.
Defective Pollen WallIs Required for Anther and Microspore Development in Rice and Encodes a Fatty Acyl Carrier Protein Reductase
Authors: Shi Jing , Tan Hexin , Yu Xiao-Hong , Liu Yuanyun , Liang Wanqi , Ranathunge Kosala , Franke Rochus Benni , Schreiber Lukas , Wang Yujiong , Kai Guoying , Shanklin John , Ma Hong , Zhang Dabing 
Published: June 2011

AbstractAliphatic alcohols naturally exist in many organisms as important cellular components; however, their roles in extracellular polymer biosynthesis are poorly defined. We report here the isolation and characterization of a rice (Oryza sativa) male-sterile mutant, defective pollen wall (dpw), which displays defective anther development and degenerated pollen grains with an irregular exine. Chemical analysis revealed that dpw anthers had a dramatic reduction in cutin monomers and an altered composition of cuticular wax, as well as soluble fatty acids and alcohols. Using map-based cloning, we identified the DPW gene, which is expressed in both tapetal cells and microspores during anther development. Biochemical analysis of the recombinant DPW enzyme shows that it is a novel fatty acid reductase that produces 1-hexadecanol and exhibits &gt;270-fold higher specificity for palmiltoyl-acyl carrier protein than for C16:0 CoA substrates. DPW was predominantly targeted to plastids mediated by its N-terminal transit peptide. Moreover, we demonstrate that the monocot DPW from rice complements the dicot Arabidopsis thaliana male sterile2 (ms2) mutant and is the probable ortholog of MS2. These data suggest that DPWs participate in a conserved step in primary fatty alcohol synthesis for anther cuticle and pollen sporopollenin biosynthesis in monocots and dicots.
Host translational control of a polydnavirus, Cotesia plutellae bracovirus, by sequestering host eIF4A to prevent formation of a translation initiation complex
Authors: Surakasi V. P. , Nalini M. , Kim Y. 
Published: June 2011

AbstractHost translational control is a viral strategy to exploit host cellular resources. Parasitization by some endoparasitoids containing polydnaviruses inhibits the synthesis of specific host proteins at post‐transcriptional level. Two host translation inhibitory factors (HTIFs) have been proposed in Cotesia plutellae bracovirus (CpBV). Parasitization by C. plutellae inhibited storage protein 1 (SP1) synthesis of Plutella xylostella at post‐transcriptional level. One HTIF, CpBV15β, inhibited the translation of SP1 mRNA in an in vitro translation assay using rabbit reticulocyte lysate, but did not inhibit its own mRNA. To further analyse the discrimination of target and nontarget mRNAs of the inhibitory effect of HTIF, 5′ untranslated regions (UTRs) of SP1 and CpBV15β mRNA were reciprocally exchanged. In the presence of HTIFs, the chimeric CpBV15β mRNA that contained SP1 5′ UTR was not translated, whereas the chimeric SP1 mRNA that contained CpBV15β 5′ UTR was translated. There was a difference in the 5′ UTR secondary structures between target (SP1) and nontarget (CpBV15α and CpBV15β) mRNAs in terms of thermal stability. Different mutant 5′ UTRs of SP1 mRNA were prepared by point mutations to modify their secondary structures. The constructs containing 5′ UTRs of high thermal stability in their secondary structures were inhibited by HTIF, but those of low thermal stability were not. Immunoprecipitation with CpBV15β antibody coprecipitated eIF4A, which would be required for unwinding the secondary structure of the 5′ UTR. These results indicate that the viral HTIF discriminates between host mRNAs according to their dependency on eIF4A to form a functional initiation complex for translation.
DNA methylation in insects: on the brink of the epigenomic era
Authors: Glastad K. M. , Hunt B. G. , Yi S. V. , Goodisman M. A. D. 
Published: June 2011

AbstractDNA methylation plays an important role in gene regulation in animals. However, the evolution and function of DNA methylation has only recently emerged as the subject of widespread study in insects. In this review we profile the known distribution of DNA methylation systems across insect taxa and synthesize functional inferences from studies of DNA methylation in insects and vertebrates. Unlike vertebrate genomes, which tend to be globally methylated, DNA methylation is primarily targeted to genes in insects. Nevertheless, mounting evidence suggests that a specialized role exists for genic methylation in the regulation of transcription, and possibly mRNA splicing, in both insects and mammals. Investigations in several insect taxa further reveal that DNA methylation is preferentially targeted to ubiquitously expressed genes and may play a key role in the regulation of phenotypic plasticity. We suggest that insects are particularly amenable to advancing our understanding of the biological functions of DNA methylation, because insects are evolutionarily diverse, display several lineage‐specific losses of DNA methylation and possess tractable patterns of DNA methylation in moderately sized genomes.