bluuebunny/crossref_metadata_2025_split huggingface dataset:
The reliability and quality of YouTube videos about isotretinoin treatment and suicide
Authors: Ünlü Açıkel Sezin , Özdemir Ahmet Kağan , Emre Selma 
Published: May 2024

Abstract

Background
Seeking health information online has drastically increased. Isotretinoin is one of the agents used to treat acne.

Objectives
In this study, we aimed to investigate the reliability and quality of YouTube videos related to acne treatment. There is a misconception that use of isotretinoin increases risk of suicide.

Methods
We used the terms ‘isotretinoin suicide’ and ‘acne treatment suicide’ to search YouTube videos. Videos that were not in English, were irrelevant, or were devoid of audio were not included. The information in the videos was primarily categorized as ‘reliable’ or ‘unreliable’ based on its scientific validation. DISCERN and the Global Quality Score were used to evaluate the videos’ overall quality.

Results
In total, 200 videos were examined and 112 videos were included in the study. Of these, 39 videos (34.8%) were found to be reliable, and 73 videos (65.2%) were found to be unreliable. The DISCERN values of videos uploaded by physicians or professional organizations, and health information websites were found to be significantly higher. There were statistically significant negative correlations between DISCERN score and both video length and the length of time the video was on YouTube, while a positive correlation was observed between DISCERN score and the number of subscribers.

Conclusions
Although videos created by dermatologists have become widespread in recent years, they are still insufficient. Patient experience videos mostly contain information that does not reflect reality, and they emphasize that isotretinoin increases the risk of suicide without evidence. As the number of dermatologists posting videos on YouTube increases, the chances of people accessing correct information will increase.
Auditory change detection and visual selective attention: association between MMN and N2pc
Authors: Kong Yuanjun , Zhao Chenguang , Li Dongwei , Li Bingkun , Hu Yiqing , Liu Hongyu , Woolgar Alexandra , Guo Jialiang , Song Yan 
Published: May 2024

Abstract
While the auditory and visual systems each provide distinct information to our brain, they also work together to process and prioritize input to address ever-changing conditions. Previous studies highlighted the trade-off between auditory change detection and visual selective attention; however, the relationship between them is still unclear. Here, we recorded electroencephalography signals from 106 healthy adults in three experiments. Our findings revealed a positive correlation at the population level between the amplitudes of event-related potential indices associated with auditory change detection (mismatch negativity) and visual selective attention (posterior contralateral N2) when elicited in separate tasks. This correlation persisted even when participants performed a visual task while disregarding simultaneous auditory stimuli. Interestingly, as visual attention demand increased, participants whose posterior contralateral N2 amplitude increased the most exhibited the largest reduction in mismatch negativity, suggesting a within-subject trade-off between the two processes. Taken together, our results suggest an intimate relationship and potential shared mechanism between auditory change detection and visual selective attention. We liken this to a total capacity limit that varies between individuals, which could drive correlated individual differences in auditory change detection and visual selective attention, and also within-subject competition between the two, with task-based modulation of visual attention causing within-participant decrease in auditory change detection sensitivity.
Urbanization does not increase “object curiosity” in vervet monkeys, but semi-urban individuals selectively explore food-related anthropogenic items
Authors: Ellington Lindsey , Mercier Stephanie , Motes-Rodrigo Alba , van de Waal Erica , Forss Sofia 
Published: May 2024

Abstract
Urban environments expose animals to abundant anthropogenic materials and foods that facilitate foraging innovations in species with opportunistic diets and high behavioral flexibility. Neophilia and exploration tendency are believed to be important behavioral traits for animals thriving in urban environments. Vervet monkeys (Chlorocebus pygerythrus) are one of few primate species that have successfully adapted to urban environments, thus making them an ideal species to study these traits. Using a within-species cross-habitat approach, we compared neophilia and exploration of novel objects (jointly referred to as “object curiosity”) between semi-urban, wild, and captive monkeys to shed light on the cognitive traits facilitating urban living. To measure “object curiosity,” we exposed monkeys to various types of novel stimuli and compared their approaches and explorative behavior. Our results revealed differences in the number of approaches and explorative behavior toward novel stimuli between the habitat types considered. Captive vervet monkeys were significantly more explorative than both semi- urban and wild troops, suggesting that positive experiences with humans and lack of predation, rather than exposure to human materials per se, influence object curiosity. Across habitats, juvenile males were the most explorative age-sex class. This is likely due to males being the dispersing sex and juveniles being more motivated to learn about their environment. Additionally, we found that items potentially associated with human food, elicited stronger explorative responses in semi-urban monkeys than non-food related objects, suggesting that their motivation to explore might be driven by “anthrophilia”, that is, their experience of rewarding foraging on similar anthropogenic food sources. We conclude that varying levels of exposure to humans, predation and pre-exposure to human food packaging explain variation in “object curiosity” in our sample of vervet monkeys.
Fibrosis-related Transcriptome Unveils a Distinctive Remodelling Matrix Pattern in Penetrating Ileal Crohn’s Disease
Authors: Tavares de Sousa Helena , Ferreira Marta , Gullo Irene , Rocha Ana Mafalda , Pedro Ana , Leitão Dina , Oliveira Carla , Carneiro Fátima , Magro Fernando 
Published: May 2024

Abstract

Background and Aims
Stricturing [B2] and penetrating [B3] ileal Crohn’s disease have been reported to present similar levels of histopathological transmural fibrosis. This study aimed to compare the fibrosis-related transcriptomic profiles of penetrating and stricturing ileal Crohn’s disease.

Methods
Using Nanostring technology and comparative bioinformatics, we analysed the expression of 787 fibrosis-related genes in 36 ileal surgical specimens, 12 B2 and 24 B3, the latter including 12 cases with associated stricture[s] [B3s] and 12 without [B3o]. Quality control of extracted RNA was performed according to Nanostring parameters and principal component analysis for the distribution analysis. For the selection of the differentially expressed genes, a p-adjusted &lt;0.05 and fold change ≤-1.5 or ≥1.5 were adopted. Quantitative polymerase chain reaction (qPCR) and immunohistochemistry analyses were used to validate selected differentially expressed genes.

Results
We included 34 patients with B2 and B3 phenotypes, balanced for age at diagnosis, age at surgery, gender, Crohn’s disease localisation, perianal disease, and therapy. Inflammation and fibrosis histopathological scoring were similar in all cases. B2 and B3 groups showed a very good clustering regarding 30 significantly differentially expressed genes, all being remarkably upregulated in B3. More than half of these genes were involved in Crohn’s disease fibrogenesis, and eight differentially expressed genes were so in other organs. The most significantly active biological processes and pathways in penetrating disease were response to TGFβ and matrix organisation and degradation, as validated by immunohistochemistry.

Conclusions
Despite the histopathological similarities in fibrosis between stricturing and penetrating ileal Crohn’s disease, their fibrosis-related transcriptomic profiles are distinct. Penetrating disease exhibits a distinctive transcriptomic landscape related to enhanced matrix remodelling.
The Effect of Non-pooled Multidonor Faecal Microbiota Transplantation for Inducing Clinical Remission in Patients with Chronic Pouchitis: Results from a Multicentre, Randomised, Double-blinded, Placebo-controlled Trial [MicroPouch]
Authors: Kousgaard Sabrina Just , Cold Frederik , Halkjær Sofie Ingdam , Petersen Andreas Munk , Kjeldsen Jens , Hansen Jane Møller , Dall Sebastian Mølvang , Albertsen Mads , Nielsen Hans Linde , Kirk Karina Frahm , Duch Kirsten , Sønderkær Mads , Thorlacius-Ussing Ole 
Published: May 2024

Abstract

Background and Aims
To investigate if treatment with non-pooled, multidonor faecal microbiota transplantation [FMT] for 4 weeks was superior to placebo to induce clinical remission in patients with chronic pouchitis.

Methods
The study was a randomised, double-blinded, placebo-controlled study with a 4-week intervention period and 12-month follow-up. Eligible patients with chronic pouchitis were recruited from five Danish hospitals. Participants were randomised to non-pooled, multidonor FMT derived from four faecal donors, or placebo. Treatment was delivered daily by enema for 2 weeks, followed by every second day for 2 weeks. Disease severity was accessed at inclusion and 30-day follow-up, using the Pouchitis Disease Activity Index [PDAI]; PDAI &lt;7 was considered equivalent to clinical remission. Faecal samples from participants and donors were analysed by shotgun metagenomic sequencing.

Results
Inclusion was stopped after inclusion of 30 participants who were randomised 1:1 for treatment with FMT or placebo. There was no difference in participants achieving clinical remission between the two groups at 30-day follow-up, relative risk 1.0 (95% CI [0.55; 1.81]). Treatment with FMT resulted in a clinically relevant increase in adverse events compared with placebo, incidence rate ratio 1.67 (95% CI [1.10; 2.52]); no serious adverse events within either group. Faecal microbiota transplantation statistically significantly increased the similarity of participant faecal microbiome to the faecal donor microbiome at 30-day follow-up [p = 0.01], which was not seen after placebo.

Conclusions
Non-pooled, multidonor FMT was comparable to placebo in inducing clinical remission in patients with chronic pouchitis, but showed a clinically relevant increase in adverse events compared with placebo. ClincialTrials.gov number, NCT04100291.
Accuracy and reliability of magnetic resonance imaging in orthodontic diagnosis and treatment planning—a systematic review and meta-analysis
Authors: Srivastav Sukeshana , Spin-Neto Rubens , Aiyar Akila , Stoustrup Peter Bangsgaard 
Published: May 2024

Summary

Background
Magnetic resonance imaging (MRI) is a non-ionizing imaging technique. Using MRI in dentistry may potentially lower the general radiation dose of the examined population, provided MRI can replace various radiation-based images. Furthermore, novel MRI imaging modalities for three-dimensional and two-dimensional cephalometrics have recently been developed for orthodontic diagnosis.

Objectives
This systematic review aimed to determine the diagnostic accuracy and reliability of MRI in orthodontic diagnosis and treatment planning.

Search methods
An electronic search was conducted on 20 November 2022 in the following databases: PubMed, LILACS, Web of Science, EMBASE, Scopus, and Cochrane. The search was updated on 30 August 2023. Furthermore, a grey literature search was performed in Google Scholar and Open-Grey.

Selection criteria
This review included descriptive, observational, cohort studies, cross-sectional, case-control studies, and randomized/non-randomized trials related to the research question. The study excluded studies related to patients with syndromes, chronic diseases, craniofacial anomalies, or bone diseases.

Data collection and analysis
The included studies were quality assessed using the “Joanna Brigg’s Critical Appraisal Tool for diagnostic test accuracy”. The GRADE approach for non-randomized studies was used for strength-of-evidence analysis.

Results
Eight of the 10 included studies compared MRI with either cone beam computed tomography or lateral cephalogram and found a high intra- and inter-rater agreement for landmark identification. The risk of bias was high in four studies, moderate in three, and low in three studies. Homogeneity was lacking among the included studies in terms of MRI imaging parameters and sample characteristics. This should be taken into consideration by future studies where uniformity with respect to these parameters may be considered.

Conclusions
Despite dissimilarity and heterogeneity in the sample population and other methodological aspects, all the included studies concluded that MRI enjoyed considerable intra- and inter-examiner reliability and was comparable to current diagnostic standards in orthodontics. Furthermore, the studies agreed on the innovative potential of MRI in radiation-free diagnosis and treatment planning in orthodontics in the future.

Registration
CRD number: CRD420223XXXXX
Septal venous channel perforation during left bundle branch area pacing: a prospective study
Authors: Ghosh Anindya , Sekar Anbarasan , Sriram Chenni S , Sivakumar Kothandam , Upadhyay Gaurav A , Pandurangi Ulhas M 
Published: May 2024

Abstract

Aims
To characterize the diagnosis, frequency, and procedural implications of septal venous channel perforation during left bundle branch area pacing (LBBAP).

Methods and results
All consecutive patients undergoing LBBAP over an 8-month period were prospectively studied. During lead placement, obligatory septal contrast injection was performed twice, at initiation (implant entry zone) and at completion (fixation zone). An intuitive fluoroscopic schema using orthogonal views (left anterior oblique/right anterior oblique) and familiar landmarks is described. Using this, we resolved zonal distribution (I–VI) of lead position on the ventricular septum and its angulation (post-fixation angle θ). Subjects with and without septal venous channel perforation were compared. Sixty-one patients {male 57.3%, median age [interquartile range (IQR)] 69.5 [62.5–74.5] years} were enrolled. Septal venous channel perforation was observed in eight (13.1%) patients [male 28.5%, median age (IQR) 64 (50–75) years]. They had higher frequency of (i) right-sided implant (25% vs. 1.9%, P = 0.04), (ii) fixation in zone III at the mid-superior septum (75% vs. 28.3%, P = 0.04), (iii) steeper angle of fixation—median θ (IQR) [19 (10–30)° vs. 5 (4–19)°, P = 0.01], and (iv) longer median penetrated-lead length (IQR) [13 (10–14.8) vs. 10 (8.5–12.5) mm, P = 0.03]. Coronary sinus drainage of contrast was noted in five (62.5%) patients. Abnormal impedance drops during implantation (12.5% vs. 5.7%, P = NS) were not significantly different.

Conclusion
When evaluated systematically, septal venous channel perforation may be encountered commonly after LBBAP. The fiducial reference framework described using fluoroscopic imaging identified salient associated findings. This may be addressed with lead repositioning to a more inferior location and is not associated with adverse consequence acutely or in early follow-up.
Accounting for subwavelength heterogeneities in full waveform inversion based on wavefield gradient measurements
Authors: Mukumoto Kota , Capdeville Yann , Singh Sneha , Tsuji Takeshi 
Published: May 2024

SUMMARY
Seismic gradient measurements from distributed acoustic sensors and rotational sensors are becoming increasingly available for field surveys. These measurements provide a wealth of information and are currently being considered for many applications such as earthquake detection and subsurface characterizations. In this work, using a simple 2-D numerical approach, we tackle the implications of such wavefield gradient measurements on full waveform inversion (FWI) techniques using a simple 2-D numerical test. In particular, we study the impact of the wavefield gradient measurement sensitivity to heterogeneities that are much smaller than the minimum wavelength. Indeed, as shown through the homogenization theory, small-scale heterogeneities induce an unexpected coupling of the strain components to the wavefield gradient measurement. We further show that this coupling introduces a potential limitation to the FWI results if it is not taken into account. We demonstrate that a gradient measurement-based FWI can only reach the accuracy of a classical displacement field-based FWI if the coupling coefficients are also inverted. Furthermore, there appears to be no specific gain in using gradient measurements instead of conventional displacement (or velocity, acceleration) measurements to image structures. Nevertheless, the inverted correctors contain fine-scale heterogeneities information that could be exploited to reach an unprecedented resolution, particularly if an array of receivers is used.
Use of artificial intelligence and the future of peer review
Authors: Bauchner Howard , Rivara Frederick P 
Published: May 2024

Abstract
Conducting high-quality peer review of scientific manuscripts has become increasingly challenging. The substantial increase in the number of manuscripts, lack of a sufficient number of peer-reviewers, and questions related to effectiveness, fairness, and efficiency, require a different approach. Large-language models, 1 form of artificial intelligence (AI), have emerged as a new approach to help resolve many of the issues facing contemporary medicine and science. We believe AI should be used to assist in the triaging of manuscripts submitted for peer-review publication.
Pediatric to Adult Transition in Inflammatory Bowel Disease: Consensus Guidelines for Australia and New Zealand
Authors: Vernon-Roberts Angharad , Chan Patrick , Christensen Britt , Havrlant Rachael , Giles Edward , Williams Astrid-Jane 
Published: May 2024

Abstract

Background
The incidence of pediatric inflammatory bowel disease (IBD) is rising, and there is an increasing need to support adolescents when they transition to adult care. Evidence supports the use of a structured transition process but there is great variation across Australasia. The study aim was to develop evidence and expert opinion–based consensus statements to guide transitional care services in IBD.

Methods
A modified UCLA-RAND methodology was employed to develop consensus statements. An IBD expert steering committee was formed and a systematic literature review was conducted to guide the drafting of consensus statements. A multidisciplinary group was formed comprising 16 participants (clinicians, nurses, surgeons, psychologists), who anonymously voted on the appropriateness and necessity of the consensus statements using Likert scales (1 = lowest, 9 = highest) with a median ≥7 required for inclusion. Patient support groups, including direct input from young people with IBD, informed the final recommendations.

Results
Fourteen consensus statements were devised with key recommendations including use of a structured transition program and transition coordinator, mental health and transition readiness assessment, key adolescent discussion topics, allied health involvement, age for transition, and recommendations for clinical communication and handover, with individualized patient considerations. Each statement reached median ≥8 for appropriateness, and ≥7 for necessity, in the first voting round, and the results were discussed in an online meeting to refine statements.

Conclusions
A multidisciplinary group devised consensus statements to optimize pediatric to adult transitional care for adolescents with IBD. These guidelines should support improved and standardized delivery of IBD transitional care within Australasia.
Investigating the Relationships Among HMP, Credibility, and TPP of News Media and Their Links to News Media Policy Support
Authors: Hyun Ki Deuk , Seo Mihye , Kim Yonghwan 
Published: May 2024

Abstract
Prior research has suggested that perceptions of bias, credibility, and influence of news media may relate to one another but there have been relatively few efforts to integrate these concepts under a coherent theoretical framework. Based on social identity theory, we examined whether political identity relates to hostile media perception (HMP), credibility, and third-person perception (TPP) and if such perceptions in tandem predict attitudes toward news media policies—restriction of news media and media literacy education, which may neutralize the influences of seemingly hostile and untrustworthy news media. Findings from two national online surveys showed that strong partisans tend to perceive stronger HMP and less credibility in news media. Additionally, progressives had greater HMP. HMP and TPP were positively associated with media restriction policy support and media literacy education support. Credibility showed negative associations with restrictive media policy support, whereas the opposite pattern was found in the relationship with media education support. Furthermore, the positive associations between HMP and media policy support were mediated by TPP. The negative associations between credibility and restrictive media policy support were also mediated by TPP.
Simultaneous automated ascertainment of prevalent vertebral fracture and abdominal aortic calcification in clinical practice: role in fracture risk assessment
Authors: Schousboe John T , Lewis Joshua R , Monchka Barret A , Reid Siobhan B , Davidson Michael J , Kimelman Douglas , Jozani Mohammad Jafari , Smith Cassandra , Sim Marc , Gilani Syed Zulqarnain , Suter David , Leslie William D 
Published: May 2024

Abstract
Whether simultaneous automated ascertainments of prevalent vertebral fracture (auto-PVFx) and abdominal aortic calcification (auto-AAC) on vertebral fracture assessment (VFA) lateral spine bone density (BMD) images jointly predict incident fractures in routine clinical practice is unclear. We estimated the independent associations of auto-PVFx and auto-AAC primarily with incident major osteoporotic and secondarily with incident hip and any clinical fractures in 11 013 individuals (mean [SD] age 75.8 [6.8] years, 93.3% female) who had a BMD test combined with VFA between March 2010 and December 2017. Auto-PVFx and auto-AAC were ascertained using convolutional neural networks (CNNs). Proportional hazards models were used to estimate the associations of auto-PVFx and auto-AAC with incident fractures over a mean (SD) follow-up of 3.7 (2.2) years, adjusted for each other and other risk factors.
At baseline, 17% (n = 1881) had auto-PVFx and 27% (n = 2974) had a high level of auto-AAC (≥ 6 on scale of 0 to 24). Multivariable-adjusted hazard ratios (HR) for incident major osteoporotic fracture (95% CI) were 1.85 (1.59, 2.15) for those with compared with those without auto-PVFx, and 1.36 (1.14, 1.62) for those with high compared with low auto-AAC. The multivariable-adjusted HRs for incident hip fracture were 1.62 (95% CI, 1.26 to 2.07) for those with compared to those without auto-PVFx, and 1.55 (95% CI, 1.15 to 2.09) for those high auto-AAC compared with low auto-AAC. The 5-year cumulative incidence of major osteoporotic fracture was 7.1% in those with no auto-PVFx and low auto-AAC, 10.1% in those with no auto-PVFx and high auto-AAC, 13.4% in those with auto-PVFx and low auto-AAC, and 18.0% in those with auto-PVFx and high auto-AAC. While physician manual review of images in clinical practice will still be needed to confirm image quality and provide clinical context for interpretation, simultaneous automated ascertainment of auto-PVFx and auto-AAC can aid fracture risk assessment.