bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is the forest conversion to pasture affecting the hydrological response of Amazonian catchments? Signals in the Ji‐Paraná Basin
Authors: Rodriguez Daniel Andres , Tomasella Javier , Linhares Claudia 
Published: January 2010

AbstractIt is well known that land use and land‐cover changes (LUCC), particularly deforestation, have the potential to modify the hydrological response. Although those signals are relatively well documented in worldwide microcatchment studies, conflicting results reported in literature indicate that those signals can be sometimes difficult to detect and isolate in basins at larger scales.In order to detect signals in the hydrological response potentially, related to LUCC, streamflow records from Ji‐Paraná Basin located in SW Amazonia are analysed in conjunction with deforestation maps derived from remote sensors. The basin has a drainage area greater than 30 000 km2 and has been through severe LUCC in the last decades.Statistical descriptors of daily streamflow series were correlated with landscape indices using non‐parametric methodologies. To take into account scale effects, statistical analyses were repeated in different sub‐basins.Results showed that the impact of LUCC on the hydrological response is time lagged at larger scales. The flow paths are clearly affected, depending on basin characteristics such as topography. In general, LUCC impacts lead to higher peak streamflows, the reduction of minimal values and the increment of stormflow. In agreement with previous studies, the detection of signals associated with LUCC was clearly detected at the smallest basin, but proved to be difficult at larger scales, suggesting the existence of non‐linear effects, which aggregate across scale compensating small scale effects. Such behaviour indicates a challenge for mathematical models, which are usually developed to represent immediate hydrological response to basin wide LUCC. Copyright © 2010 John Wiley & Sons, Ltd.
Scale and model resolution effects on the distributions of advective solute travel times in catchments
Authors: Darracq Amélie , Destouni Georgia , Persson Klas , Prieto Carmen , Jarsjö Jerker 
Published: January 2010

AbstractAdvective solute travel times and their distributions in hydrological catchments are useful descriptors of the dynamics and variation of the physical mass transport among and along the different source‐to‐recipient pathways of solute transport through the catchments. This article investigates the scale dependence and the effects of model and data resolution on the quantification of advective travel times and their distributions in the Swedish catchment areas of Norrström and Forsmark. In the surface water networks of the investigated (sub)catchments, the mean advective travel time increases with (sub)catchment scale, whereas the relative travel time variability around the mean value (coefficient of variation, CV) is scale‐invariant and insensitive to model resolution. In the groundwater and for the whole (sub)catchments, both the mean value and the CV of travel times are scale‐invariant, but sensitive to model resolution and accuracy. Such quantifications and results of advective travel times constitute important steps in the development of improved understanding and modelling of nutrient, pollutant and tracer transport through catchments. Copyright © 2010 John Wiley & Sons, Ltd.
Insulin‐like growth factor‐1 receptor as a novel prognostic marker and its implication as a cotarget in the treatment of human adenocarcinoma of the esophagus
Authors: Kalinina Tatyana , Bockhorn Maximilian , Kaifi Jussuf T. , Thieltges Sabrina , Güngör Cenap , Effenberger Katharina E. , Strelow Andrea , Reichelt Uta , Sauter Guido , Pantel Klaus , Izbicki Jakob R. , Yekebas Emre F. 
Published: January 2010

AbstractInsulin‐like growth factor‐1 receptor (IGF‐1R) and human epidermal growth factor receptor‐2 (HER2) receptor expression has been found to be a key regulator of tumorigenesis. The purpose of our study was to establish the prognostic significance of IGF‐1R in esophageal cancer and to determine the effect of IGF‐1R and HER2 targeting with α‐IR3 and Herceptin™ antibodies on the proliferation of esophageal cancer cells in vitro. IGF‐1R expression and clinicopathological correlations were analyzed with a tissue microarray containing 234 esophageal cancer specimens (133 adenocarcinomas and 101 squamous cell carcinomas). Proliferation changes associated with Herceptin™ and α‐IR3 blockage were evaluated with the unique human esophageal cancer cell lines Pt1590 and LN1590. IGF‐1R and HER2 expression levels, activation and phosphorylation status of downstream signaling proteins involved in the activation pathways were analyzed by Western blotting. IGF‐1R overexpression was detected in 121 (52%) of the 234 esophageal tumors examined. In the subgroup of 87 HER2‐positive tumors, 93.1% showed concordant overexpression for IGF‐1R. IGF‐1R was identified as a variable associated with reduced overall survival for adenocarcinoma (p = 0.05), but not for squamous cell carcinoma. The combination of Herceptin™ and α‐IR3 was more effective in inhibiting in vitro proliferation than treatment with either agent alone (p < 0.01). This was associated with a decrease in HER2 and IGF‐1R protein levels and suppression of Akt‐ and MAP kinase phosphorylation. IGF‐1R expression can be used as a novel prognostic marker for adenocarcinomas of the esophagus. Cotreatment with IGF‐1R and HER2 antibodies might become a valuable and effective treatment option in esophageal adenocarcinoma.
Comparison of natural histories of human papillomavirus detected by clinician‐ and self‐sampling
Authors: Moscicki Anna‐Barbara , Widdice Lea , Ma Yifei , Farhat Sepideh , Miller‐Benningfield Susanna , Jonte Janet , Jay Julie , Godwin de Medina Cheryl , Hanson Evelyn , Clayton Lisa , Shiboski Stephen 
Published: January 2010

AbstractNew strategies for cervical cancer screening include human papillomavirus (HPV) DNA testing. Using self‐testing methods would increase access to testing in both developed and developing countries. The purpose of this study was to compare time‐to‐clearance of specific HPV types between clinician‐collected‐lavage (CC‐L) and self‐collected (SC) sampling in a single cohort. CC‐L and SC samples were obtained every 4 months at alternate 2‐month windows from 537 women. Eighteen high‐risk (HR) HPV and 4 low‐risk (LR) HPV were examined. Proportional hazards model was used to compare time‐to‐clearance between methods for combined HR and for 13 specific HPV types. Prentice‐Wilcoxon test was used for within‐subject paired comparison. In the independent analysis for combined HR and LR types, no differences were found. For specific types, time‐to‐clearance for all HPV types examined between CC‐L and SC samples was similar except for HPV 66 which showed a trend to clear slower by SC (p = 0.09). When comparing methods in the same woman, time‐to‐clearance was similar for all types except for HPV 16 which showed a trend to clear slower by CC‐L means (p = 0.08). When we examined pattern of clearance among the CC‐L samples, the fastest types to clear were HPV 6, 18, 66, 84 and 39 and the slowest were HPV 62, 68, 59 and 16. These patterns of fast and slow were similar for SC samples. Our findings suggest using SC vaginal swabs would observe similar natural histories of HPV compared to studies using CC‐L specimens making self‐testing feasible for repeated HPV DNA detection.
Silencing of the UCHL1 gene in giant cell tumors of bone
Authors: Fellenberg Jörg , Lehner Burkhard , Witte Daniela 
Published: January 2010

AbstractGiant cell tumors are heterogeneous tumors consisting of multinucleated giant cells, fibroblast‐like stromal cells and mononuclear histiocytes. The stromal cells have been identified as the neoplastic cell population, which promotes the recruitment of histiocytes and the formation of giant cells. Strong evidence exists that these cells develop from mesenchymal stem cells (MSCs) but little is known about the molecular mechanisms involved in GCT tumorigenesis. The aim of our study was the identification of cancer‐related genes differentially expressed in GCTs compared to MSCs in order to identify possible targets for aberrant promoter methylation, which may contribute to MSC transformation and GCT development. Gene expression of 440 cancer‐related genes was analyzed by DNA microarrays in GCT stromal cells and bone marrow‐derived MSCs (BMSCs) isolated from the same patient (n = 3) to avoid interindividual variations. Differential expression was identified for 14 genes, which could be confirmed by quantitative PCR in further 21 GCT and 10 BMSC samples. The most pronounced difference in gene expression was detected for UCHL1, an important regulator of the ubiquitin proteasome pathway. Methylation‐specific PCR and bisulfite sequencing revealed a strong methylation of the CpG island covering the UCHL1 promoter in GCT stromal cells, whereas methylation was completely absent in BMSCs. UCHL1 expression in stromal cells could be restored by the methylation inhibitor 5‐aza‐dC. These data demonstrate that the UCHL1 gene is inactivated in GCTs but not in MSCs, suggesting a possible role of UCHL1 in MSC transformation and GCT development.
Diagnosis of rheumatoid arthritis using light: correction of motion artefacts and color visualization of multispectral images
Authors: Minet Olaf , Scheibe Patrick , Zabarylo Urszula J. 
Published: January 2010

AbstractState‐of‐the‐art image‐processing methods offer new possibilities for diagnosing diseases using scattered light. The optical diagnosis of rheumatism is taken as an example to show that the diagnostic sensitivity can be improved using overlapped pseudocolored images of different wavelengths, provided that multispectral images are recorded to compensate for any motion‐related artefacts that occur during examination. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Predictors of serious injury among hospitalized patients evaluated for falls
Authors: Bradley Sara M. , Karani Reena , McGinn Thomas , Wisnivesky Juan 
Published: January 2010

AbstractBACKGROUND:Inpatient falls are common and result in significant patient morbidity.OBJECTIVE:To identify predictors of serious injury being found on imaging studies of inpatients evaluated after a fall.DESIGN:Retrospective study.SETTING:An 1171‐bed urban academic medical center.PATIENTS:All inpatients who fell on thirteen medical and surgical units from January 1 to December 31, 2006.MEASUREMENTS:Patient characteristics, circumstances surrounding falls, fall‐related injuries, and length of stay were collected through review of incident reports and computerized medical records. Primary outcome of fall‐related injury was determined by evidence of injury on imaging studies within two weeks of the fall. Univariate and multivariate logistic regression were used to calculate adjusted odds ratios (ORs) for injury after an inpatient fall.RESULTS:A total of 513 patients had 636 falls during the study time period. Fall incidence rate was 1.97 falls per 1,000 patient days. 95 patients (19%) fell multiple times (range, 2‐6 events); 74% of the falls occurred in patients who were previously assessed as being “at risk” by the nursing staff. Multivariate analysis, adjusting for age and sex, found evidence of trauma after a fall (OR = 24.6, P < 0.001) and ambulatory status (OR = 7.3, P < 0.01) to be independent predictors of injury being found on imaging studies.CONCLUSIONS:Inpatient falls are common despite high‐risk patients being identified. After adjusting for age and sex, evidence of trauma and ambulatory status were independent predictors of an injury being found on imaging studies after an inpatient fall. Journal of Hospital Medicine 2010;5:63–68. © 2010 Society of Hospital Medicine.
Impact and recognition of cognitive impairment among hospitalized elders
Authors: Boustani Malaz , Baker Mary Shearer , Campbell Noll , Munger Stephanie , Hui Siu L. , Castelluccio Pete , Farber Mark , Guzman Oscar , Ademuyiwa Adetayo , Miller David , Callahan Chris 
Published: January 2010

AbstractBACKGROUND:Older adults are predisposed to developing cognitive deficits. This increases their vulnerability for adverse health outcomes when hospitalized.OBJECTIVE:To determine the prevalence and impact of cognitive impairment (CI) among hospitalized elders based on recognition by lCD‐coding versus screening done on admission.DESIGN:Observational cohort study.SETTING:Urban public hospital in Indianapolis.PATIENTS:997 patients age 65 and older admitted to medical services between July 2006 and March 2008.MEASUREMENTS:Impact of CI in terms of length of stay, survival, quality of care and prescribing practices. Cognition was assessed by the Short Portable Mental Status Questionnaire (SPMSQ).RESULTS:424 patients (43%) were cognitively impaired. Of those 424 patients with CI, 61% had not been recognized by ICD‐9 coding. Those unrecognized were younger (mean age 76.1 vs. 79.1, P <0.001); had more comorbidity (mean Charlson index of 2.3 vs.1.9, P = 0.03), had less cognitive deficit (mean SPMSQ 6.3 vs. 3.4, P < 0.001). Among elders with CI, 163 (38%) had at least one day of delirium during their hospital course. Patients with delirium stayed longer in the hospital (9.2 days vs. 5.9, P < 0.001); were more likely to be discharged into institutional settings (75% vs. 31%, P < 0.001) and more likely to receive tethers during their care (89% vs. 69%, P < 0.001), and had higher mortality (9% vs. 4%, P = 0.09).CONCLUSION:Cognitive impairment, while common in hospitalized elders, is under‐recognized, impacts care, and increases risk for adverse health outcomes. Journal of Hospital Medicine 2010;5:69–75. © 2010 Society of Hospital Medicine.
Management of perioperative hypertensive urgencies with parenteral medications
Authors: Ahuja Kartikya , Charap Mitchell H. 
Published: January 2010

AbstractBACKGROUND:Hypertension is the major risk factor for cardiovascular (CV) disease such as myocardial infarction (MI) and stroke. This risk is well known to extend into the perioperative period. Although most perioperative hypertension can be managed with the patient's outpatient regimen, there are situations in which oral medications cannot be administered and parenteral medications become necessary. They include postoperative nil per os status, severe pancreatitis, and mechanical ventilation. This article reviews the management of perioperative hypertensive urgency with parenteral medications.METHODS:A PubMed search was conducted by cross‐referencing the terms “perioperative hypertension,” “hypertensive urgency,” “hypertensive emergency,” “parenteral anti‐hypertensive,” and “medication.” The search was limited to English‐language articles published between 1970 and 2008. Subsequent PubMed searches were performed to clarify data from the initial search.RESULTS:As patients with hypertensive urgency are not at great risk for target‐organ damage (TOD), continuous infusions that require intensive care unit (ICU) monitoring and intraarterial catheters seem to be unnecessary and a possible misuse of resources.CONCLUSIONS:When oral therapy cannot be administered, patients with hypertensive urgency can have their blood pressure (BP) reduced with hydralazine, enalaprilat, metoprolol, or labetalol. Due to the scarcity of comparative trials looking at clinically significant outcomes, the medication should be chosen based on comorbidity, efficacy, toxicity, and cost. Journal of Hospital Medicine 2010;5:E11–E16. © 2010 Society of Hospital Medicine.
Atlantic and Pacific sea surface temperatures and corn yields in the southeastern USA: lagged relationships and forecast model development
Authors: Martinez Christopher J. , Jones James W. 
Published: January 2010

AbstractSea surface temperatures (SSTs) can provide valuable predictive information for regional climate and agricultural yields in many parts of the world. This study was conducted to identify relationships between Atlantic and Pacific SSTs and corn yields in Alabama, Florida, and Georgia and to use these relationships to develop forecasts that can be used at lead times prior to spring planting. The relationships between seasonal SSTs and detrended county corn yields were analysed using singular value decomposition (SVD) analysis and confirmed using principal component analysis (PCA). Using a Monte Carlo approach, field‐significant results were found with SSTs in the July–September (JAS−1) and October–December (OND−1) seasons in the previous year and with the January–March (JFM) season of the current. A significant portion of the variability of SSTs with corn yield residuals was connected with anomalous heating and cooling associated with the El Niño Southern Oscillation (ENSO). Based on the results found by SVD analysis and confirmed by PCA, indices of spatially averaged SSTs in regions of the North Pacific and Atlantic Oceans were derived. Using these indices along with the Niño3.4 index to represent tropical Pacific SSTs, cross‐validated multiple linear regression models were developed to predict corn yield residuals using index values in the JAS−1 and OND−1 seasons. Using the cross‐validated models 91.5 and 98.4% of forecasted county corn yield residuals showed predictive skill (based on tercile hit scores) with seasonal index values in the JAS−1 and OND−1 seasons, respectively. The results of the models indicate that the indices of SSTs show significant predictability with corn yield residuals at lead times up to 4–7 months prior to spring planting and are a significant improvement over the use of an index of ENSO alone. Copyright © 2010 Royal Meteorological Society
Molecular structure, vibrational spectroscopic studies and NBO analysis of the 3,5‐dichlorophenylboronic acid molecule by the density functional method
Authors: Ayyappan S. , Sundaraganesan N. , Kurt M. , Sertbakan T. R. , Özduran M. 
Published: January 2010

AbstractIn this study, the Fourier‐transform infrared (FT‐IR) and FT‐Raman spectra of 3,5‐dichlorophenylboronicacid (3,5‐dcpba) were recorded in the solid phase. The structural and spectroscopic analysis of the 3,5‐dichlorophenylboronic was made by using density functional harmonic calculations. There are three conformers for this molecule. The computational results diagnose the most stable conformer of 3,5‐dcpba as the ct form. The geometrical parameters and energies have been obtained for all three conformers from DFT (B3LYP) with 6‐311+ + G(d,p) basis set calculations. The vibrations of stable and unstable conformers of 3,5‐dcpba are researched by using quantum chemical calculations. The complete assignments were performed on the basis of the total energy distribution (TED) of the vibrational modes calculated with the scaled quantum mechanics (SQM) method. The stability of the molecule arising from hyperconjugative interactions and charge delocalization has been analyzed using the natural bond orbital (NBO) analysis. The results show that the charge in electron density (ED) in the π* and σ* antibonding orbitals and E2 energies confirms the occurrence of ıntermolecular charge transfer (ICT) within the molecule. Finally, the calculation results were applied to simulated infrared and Raman spectra of the title compound, which show agreement with the observed spectra. Copyright © 2010 John Wiley & Sons, Ltd.
Bacterial mixture identification using Raman and surface‐enhanced Raman chemical imaging
Authors: Guicheteau Jason , Christesen Steven , Emge Darren , Tripathi Ashish 
Published: January 2010

AbstractThe ability of normal Raman and surface‐enhanced Raman scattering (SERS) to identify and detect bacteria has shown great success in recent studies. The addition of silver nanoparticles to bacterial samples not only results in an enhanced Raman signal, but it also suppresses the native fluorescence associated with biological material. In this report, Raman chemical imaging (RCI) was used to analyze individual bacteria and complex mixtures of spores and vegetative cells. RCI uses every pixel or a binned pixel group (BPG) of the Raman camera as an independent Raman spectrograph, allowing collection of spatially resolved Raman spectra. The advantage of this technique resides primarily in the analysis of samples in complex backgrounds without the need for physically isolating or purifying the sample. Using a chemical imaging Raman microscope, we compare normal RCI to SERS‐assisted chemical imaging of mixtures of bacteria. In both cases, we are able to differentiate single bacterium in the Raman microscope's field of view, with a 60‐fold reduction in image acquisition time and a factor of 10 increase in the signal‐to‐noise ratio for SERS chemical imaging over normal RCI. Copyright © 2010 John Wiley & Sons, Ltd.
Effects of conformation and hydrogen bonding on the CC and NCN stretching Raman bands of N‐deuterated histidinium
Authors: Hiramatsu Hirotsugu , Miki Noriko , Takeuchi Hideo 
Published: January 2010

AbstractHistidine is an important and versatile amino acid residue that plays a variety of structural and functional roles in proteins. Although the Raman bands of histidine are generally weak, histidine in the N‐deuterated cationic form with imidazole NπD and NτD bonds (N‐deuterated histidinium) gives two strong Raman bands assignable to the C4C5 stretch (νCC) and the NπC2Nτ symmetric stretch (νNCN) of the imidazole ring. We examined the Raman spectra of N‐deuterated histidinium in 12 crystals with known structures. The observed νCC and νNCN wavenumbers were analyzed to find empirical correlations with the conformation and hydrogen bonding. The effect of conformation on the vibrational wavenumber was expressed as a threefold cosine function of the CαCβC4C5 torsional angle. The effect of hydrogen bonding at Nπ or Nτ was assumed to be proportional to the inverse sixth power of the distance between the hydrogen and acceptor atoms. Multiple linear regression analysis clearly shows that the conformational effect on the vibrational wavenumber is comparable for νCC and νNCN. The hydrogen bond at Nπ weakly lowers the νCC wavenumber and substantially raises the νNCN wavenumber. On the other hand, the hydrogen bond at Nτ strongly raises the νCC wavenumber but does not affect the νNCN wavenumber. These empirical correlations may be useful in Raman spectral analysis of the conformation and hydrogen bonding states of histidine residues in proteins. Copyright © 2010 John Wiley & Sons, Ltd.
The impact of reported direct and indirect killing on mental health symptoms in Iraq war veterans
Authors: Maguen Shira , Lucenko Barbara A. , Reger Mark A. , Gahm Gregory A. , Litz Brett T. , Seal Karen H. , Knight Sara J. , Marmar Charles R. 
Published: January 2010

AbstractThis study examined the mental health impact of reported direct and indirect killing among 2,797 U.S. soldiers returning from Operation Iraqi Freedom. Data were collected as part of a postdeployment screening program at a large Army medical facility. Overall, 40% of soldiers reported killing or being responsible for killing during their deployment. Even after controlling for combat exposure, killing was a significant predictor of posttraumatic disorder (PTSD) symptoms, alcohol abuse, anger, and relationship problems. Military personnel returning from modern deployments are at risk of adverse mental health conditions and related psychosocial functioning related to killing in war. Mental health assessment and treatment should address reactions to killing to optimize readjustment following deployment.