bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytogenetic and molecular responses in chronic phase chronic myeloid leukaemia patients receiving low dose of imatinib for intolerance to standard dose
Authors: Breccia Massimo , Cannella Laura , Stefanizzi Caterina , Latagliata Roberto , Nanni Mauro , Diverio Daniela , Santopietro Michelina , Federico Vincenzo , Alimena Giuliana 
Published: September 2009

AbstractImatinib mesylate is the gold standard treatment of chronic myeloid leukaemia (CML) and 400 mg/day is considered the standard dose. Although it is generally well tolerated, some patients require temporary drug discontinuation and permanent dose reduction because of haematological or non‐haematological toxicities. Whether or not reduced doses are effective as the standard dose in inducing and/or maintaining complete cytogenetic and molecular response is not clear. We report the outcome of 45 CML patients in early (17) and late (28) chronic phase (CP) in whom, within a series of 250 patients treated with imatinib, reduced the dose of the drug after experiencing adverse events. Median time interval between the start of therapy and dose reduction was 58 days, whereas median administered dose was 300 mg/day. At 6 months from reduction, major cytogenetic responses (MCRs) were observed in 67% of patients, with 58% being complete cytogenetic remission (CCR), and complete molecular response (CMR) were obtained in 18% of patients. At 12 months, all patients who had obtained MCR reached CCR: this was significantly higher in low risk patients (87%) versus non‐low risk patients (66 and 46%), and in early phase (82%) versus late phase (53.5%). CMR and major molecular response (MMR) were detected in 20 and 22% of patients, respectively. Low dose imatinib appears effective in patients with intolerance to standard dose, even though long‐term effects remain to be established. Copyright © 2009 John Wiley & Sons, Ltd.
CT‐guided percutaneous lung biopsies in patients with haematologic malignancies and undiagnosed pulmonary lesions
Authors: Gupta Sanjay , Sultenfuss Mark , Romaguera Jorge E. , Ensor Joe , Krishnamurthy Savitri , Wallace Michael J. , Ahrar Kamran , Madoff David C. , Murthy Ravi , Hicks Marshall E. 
Published: September 2009

AbstractWe searched the electronic patient database at The University of Texas M. D. Anderson Cancer Center for patients who underwent computed tomography (CT)‐guided needle biopsy between January 2001 and December 2005. Inclusion criteria were a known history of haematologic malignancy and a newly detected, undiagnosed pulmonary lesion on chest CT that required tissue sampling for diagnosis; 213 met these criteria. We analysed the biopsy results for diagnostic yield, factors affecting diagnostic yield and effect on treatment. Of 213 procedures, 191 (89.7%) yielded sufficient material for pathologic analysis; 130 (60%) yielded specific diagnoses, while 61 (28.6%) yielded nonspecific benign diagnoses. Lesions larger than 1 cm, cavitary lesions and lung masses were more likely to yield a specific diagnosis than were lesions smaller than 1 cm, lung nodules and consolidations. The most common specific diagnoses were malignancy (62.8%) and infection (34.3%). The latter was more common in patients with leukaemia, cavitary lung lesions or consolidations, active underlying malignancy, neutropenia, respiratory signs and symptoms and/or fever, bone marrow transplant recipients, and in patients receiving chemotherapy. Lung lesions discovered upon follow‐up imaging in patients who did not have any respiratory signs/symptoms or fever were mostly malignant. Therapeutic changes were more likely after a specific diagnosis than after a nonspecific diagnosis or a nondiagnostic biopsy (88.4% vs. 18.1%; p < 0.0001). CT‐guided lung biopsy has a high diagnostic yield in patients with haematologic malignancies that present with unexplained pulmonary lesions and provides a specific diagnosis in a majority of these patients, leading to therapeutic changes. Copyright © 2009 John Wiley & Sons, Ltd.
How newcomers learn the social norms of an organization: A case study of the socialization of newly hired engineers
Authors: Korte Russell F. 
Published: September 2009

AbstractCurrent scholarship views organizational socialization as a learning process that is primarily the responsibility of the newcomer. Yet recent learning research recognizes the importance of the social interactions in the learning process. This study investigated how newly hired engineers at a large manufacturing company learned job‐related tasks and the social norms of the organization. From the perspective of social exchange theory, two major findings emerged from the data: (1) relationship building was the primary driver of socialization, and (2) the work group was the primary context for socialization. These findings challenge the current views of organizational socialization by accentuating the relational processes that mediate learning during socialization.
Preferences for training options: A conjoint analysis
Authors: Gan Chui Goh , Lee Julie Anne , Soutar Geoffrey N. 
Published: September 2009

AbstractSingapore is a growing educational hub for the Asia Pacific region. However, no prior research has examined how Singaporean managers trade off attributes of training programs when making executive training decisions. The current study used conjoint analysis to identify the most important attributes of training programs as word of mouth, trainers' practical experience, and institutional reputation. Three clearly distinct segments were found: pragmatic executives, who preferred experienced trainers and were somewhat pricesensitive; willing‐to‐pay executives, who were willing to pay higher fees; and quality‐conscious executives, who preferred attribute levels that relate to high quality, including trainers with a higher level of practical experience and an above‐average institutional reputation.
Antecedents and outcomes of workplace incivility: Implications for human resource development research and practice
Authors: Reio Thomas G. , Ghosh Rajashi 
Published: September 2009

AbstractThis cross‐sectional, correlational study (N = 402) examined the relationships among select demographics, workplace adaptation, employee affect, and incivility and physical health and job satisfaction. The paper‐and‐pencil survey battery consisted of nine scales. The hypotheses were tested through correlational, factor analytic, and hierarchical regression analytic procedures. Younger males engaged more frequently in uncivil behavior. After statistically controlling for the demographic variables, high negative affect and low degree of establishing relationships with coworkers and supervisors (adaptation) predicted more incivility. For the physical health model, establishing relationships with coworkers and positive affect positively contributed to perceived physical health, while organizational incivility negatively contributed to the dependent variable. As for the job satisfaction model, establishing relationships with coworkers and supervisors and positive affect positively predicted satisfaction, whereas negative affect and incivility made negative contributions to the regression equation. In all cases, the magnitude of effect ranged from medium to large, supporting the theoretical, empirical, and practical relevance of understanding the detrimental effects of uncivil behaviors on organizational outcomes. HRD researchers and professionals are highlighted as possible means for reducing uncivil workplace behaviors and improving organizational performance.
How does satisfaction translate into performance? An examination of commitment and cultural values
Authors: Zhang Jin , Zheng Wei 
Published: September 2009

AbstractThe purpose of this study is to add new insights into the mechanism through which job satisfaction relates to job performance. Affective commitment was tested as a potential mediator between job satisfaction and job performance, and traditionality was used as a potential moderator between job satisfaction and affective commitment. A survey study was conducted on 292 employees from seven companies in China. The study findings suggest that affective commitment serves as one of the mechanisms through which job satisfaction influences job performance. Job satisfaction can strengthen people's identification with, involvement in, and emotional attachment to their organization which in turn can foster better performance. The second major finding of this study is that cultural values influence how well people translate job satisfaction into affective commitment. People who are culturally more traditional tend to transfer their satisfaction with their job into stronger commitment than people lower in cultural traditionality. HRD implications are drawn.
Gentamicin‐impregnated chitosan/nanohydroxyapatite/ethyl cellulose microspheres granules for chronic osteomyelitis therapy
Authors: Shi Pujiang , Zuo Yi , Li Xiaowei , Zou Qin , Liu Haohuai , Zhang Li , Li Yubao , Morsi Yos S 
Published: September 2009

AbstractIn this article gentamicin (GM) impregnated microspheres were used to extend the drug release time for the treatment of chronic osteomyelitis. The granules were prepared in solution and consisted of nanohydroxyapatite (nHA), chitosan (CS) and GM loaded ethyl cellulose (EC) microspheres. A rabbit model with chronic osteomyelitis was made by using staphylococcus aureus and morrhuate sodium and special inspection methods were used to test the curative effects of the granules, such as microbiological investigations, tissue, and X‐ray observations. The granules were provided with excellent drug release properties, 49 days in vitro and 45 days in vivo, moreover, they showed almost no cytotoxic for fibroblast and osteoblast. The findings indicated that the GM‐impregnated CS/nHA/EC microspheres granules showed outstanding curative effect. Generally, it can be concluded that the granules containing GM impregnated microspheres may be used effectively in the treatment of the chronic osteomyelitis. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010
Biochemical investigation of the effects of human platelet releasates on human articular chondrocytes
Authors: Spreafico Adriano , Chellini Federico , Frediani Bruno , Bernardini Giulia , Niccolini Silvia , Serchi Tommaso , Collodel Giulia , Paffetti Alessandro , Fossombroni Vittorio , Galeazzi Mauro , Marcolongo Roberto , Santucci Annalisa 
Published: September 2009

AbstractThe aim of the present study was to demonstrate the mitogenic and differentiating properties of platelet‐rich plasma releasates (PRPr) on human chondrocytes in mono‐ and three‐dimensional cultures. In order to assess if PRPr supplementation could maintain the chondrocyte phenotype or at least inhibit the cell de‐differentiation even after several days in culture, we performed a proteomic study on several cell cultures independently grown, for different periods of time, in culture medium with FCS, human serum (HS), and releasates obtained from PRP and platelet‐poor plasma (PPP). We found that PRP treatment actually induced in chondrocytes the expression of proteins (some of which novel) involved in differentiation. J. Cell. Biochem. 108: 1153–1165, 2009. © 2009 Wiley‐Liss, Inc.
Did Paul Kammerer discover epigenetic inheritance? A modern look at the controversial midwife toad experiments
Authors: Vargas Alexander O. 
Published: September 2009

AbstractThe controversy surrounding the alleged Lamarckian fraud of Paul Kammerer's midwife toad experiments has intrigued generations of biologists. A re‐examination of his descriptions of hybrid crosses of treated and nontreated toads reveals parent‐of‐origin effects like those documented in epigenetic inheritance. Modification of the extracellular matrix of the egg as described by Kammerer provides a plausible cause for altered gene methylation patterns. Traits such as altered egg and adult body size in Kammerer's “treated” toads are inherited epigenetically in other tetrapods. A preliminary model involving the environmental silencing of a maternally inherited allele can be attempted to explain the midwife toad experiments. Given available molecular tools and our current understanding of epigenetics, new experimentation with the midwife toad is strongly encouraged. J. Exp. Zool. (Mol. Dev. Evol.) 312B:667–678, 2009. © 2009 Wiley‐Liss, Inc.
About the reaction of β‐dimethylamino‐α,β‐enones with active methylene nitriles
Authors: Abdelrazek Fathy M. , Elsayed Akram N. 
Published: September 2009

Abstract
magnified imageThe reaction of 3‐dimethylamino‐1‐arylpropenone derivatives with active methylene nitriles was reinvestigated and a plausible mechanism to account for the results is suggested. X‐ray crystallographic study supported the suggested mechanism. Based on these findings, the reaction of 3‐acetylamino‐4‐dimethylaminobut‐3‐en‐2‐one with malononitrile was also reinvestigated and the correct structures verified. J. Heterocyclic Chem., (2009).
A basic ionic liquid catalyzed reaction of benzothiazole, aldehydes, and 5,5‐dimethyl‐1,3‐cyclohexanedione: Efficient synthesis of tetrahydrobenzo[b]pyrans
Authors: Wen Li‐Rong , Xie Huai‐Yuan , Li Ming 
Published: September 2009

Abstract
magnified imageA fast, mild, and quantitative procedure for the preparation of tetrahydrobenzo[b]pyran derivatives in the presence of an easily accessible basic ionic liquid—[bmIm]OH(3‐butyl‐1‐methylimidazoliumhydroxide) as the catalyst has been developed. The ionic liquid was stable during the reaction process and could also be reused at least nine times with consistent activity. This procedure may be a practical alternative to the existing procedures to meet the need of academe as well as industries. J. Heterocyclic Chem., (2009).
Palladium‐catalyzed cross‐coupling reaction of 2‐ and/or 5‐substituted 4,6‐dichloropyrimidines with arylboronic acids
Authors: Tumkevicius S. , Dodonova J. , Baskirova I. , Voitechovicius A. 
Published: September 2009

Abstract
magnified imageThe Suzuki‐Miyaura reaction of some 4,6‐dichloropyrimidines bearing methylthio‐, methyl‐, amino‐, cyano‐, formyl‐, and nitro groups in positions 2 and/or 5 of the pyrimidine ring with arylboronic acids has been investigated. Influence of palladium catalyst, ligand, base, and solvent on the reaction outcome was studied. The reaction was found to give the corresponding 4,6‐diarylpyrimidines in reasonable yields using Pd(OAc)2/PPh3/K3PO4 or Pd(PPh3)2Cl2/K3PO4 as catalyst systems. J. Heterocyclic Chem., (2009).
A facile and efficient synthesis of N‐substituted furo[3,4‐b]indeno[2,1‐e]pyridine analogues of azapodophyllotoxin via microwave‐assisted multicomponent reactions
Authors: Shi Feng , Zhang Ge , Zhang Yan , Ma Ning , Jiang Bo , Tu Shu‐Jiang 
Published: September 2009

Abstract
magnified imageThe efficient and facile synthesis of N‐substituted furo[3,4‐b]indeno[2,1‐e]pyridine analogues of azapodophyllotoxin was achieved via microwave‐assisted multicomponent reactions of aldehyde, 2H‐indene‐1,3‐dione and 4‐(arylamino)furan‐2(5H)‐one in glycol without catalyst. This method has the obvious advantages over traditional heating ones on short reaction time, high yield, operational simplicity as well as being environmental friendly. J. Heterocyclic Chem., (2009).
One‐pot synthesis of imidazo[1,2‐c]quinazoline derivatives from nitro‐componds reduced by zinc
Authors: Shi Da‐Qing , Rong Shao‐Feng , Dou Guo‐Lan , Wang Man‐Man 
Published: September 2009

Abstract
magnified imageAn efficient, convenient, one‐pot synthesis of imidazo[1,2‐c]quinazolines was accomplished in good yields via the novel reductive cyclization of 2‐(2‐nitrophenyl)‐1H‐imidazole with isothiocyanates mediated by zinc dust. J. Heterocyclic Chem., (2009).
1963: The break point of the Northern Hemisphere temperature trend during the twentieth century
Authors: Ivanov Martin A. , Evtimov Stilian N. 
Published: September 2009

AbstractBesides gradually, climate can also change abruptly. The global surface temperature series is a major indicator of such changes. Using rigorous statistical tools, we show that during the twentieth century the time series of annual Northern Hemisphere surface temperature is well described by a trend‐stationary process, but the trend line breaks in 1963. After six transitory years, in 1970, the temperature course locks up into a new regime with a triple linear warming rate. For the emergence and abruptness of the break we reveal the key roles of the Mount Agung eruption and the interannual to interdecadal changes of the major modes and patterns of climate variability. We offer an abrupt climate shift scenario based on the adaptivity of climatic regimes against instant external forcings. Copyright © 2009 Royal Meteorological Society
Biological significance of the maximum standardized uptake values on positron emission tomography in non‐small cell lung cancer
Authors: Takenaka Tomoyoshi , Yano Tokujiro , Ito Kensaku , Morodomi Yousuke , Miura Naoko , Kawano Daigo , Shoji Fumihiro , Abe Koichiro , Honda Hiroshi , Maehara Yoshihiko 
Published: September 2009

AbstractBackgroundThe 2‐[18F]‐fluoro‐2‐deoxy‐d‐glucose positron emission tomography (FDG‐PET) has recently become an important non‐invasive tool for the diagnosis and staging in several cancers. The standardized uptake value (SUV) of primary tumor has been reported to relate to cancer progression and prognosis, however, biological mechanism is still unclear.MethodSeventy‐nine patients with non‐small cell lung cancer (NSCLC) who had undergone preoperative FDG‐PET and a surgical resection were enrolled in this study. NSCLC tissue samples prepared from the surgical specimens were subjected to an immunohistochemical analysis for the expression of Ki‐67 and vascular endothelial growth factor (VEGF) proteins. The relationships between the expression status of these proteins and SUVmax of primary tumors were evaluated.ResultConcerning the relationship with various clinicopathological findings, SUVmax of primary tumors was associated with histology, tumor proliferation, pleural or vascular invasion, and pathological stage. A significant correlation was observed between the SUVmax and either the Ki‐67 or VEGF expression (P < 0.001, P = 0.006), respectively. Cases with both Ki‐67‐negative and VEGF‐negative findings exhibited a significantly lower SUVmax than those with single positive or double positive cases (P = 0.006, P < 0.001).ConclusionThe SUVmax was associated with the expression of Ki‐67 and VEGF in NSCLC. These findings indicated that the SUVmax of primary tumors might therefore reflect the biological malignant potential in NSCLC. J. Surg. Oncol. 2009;100:688–692. © 2009 Wiley‐Liss, Inc.
Long‐term outcomes after laparoscopy‐assisted gastrectomy for advanced gastric cancer: Analysis of consecutive 106 experiences
Authors: Lee Junhyun , Kim Wook 
Published: September 2009

AbstractBackground and ObjectivesThe purpose of this retrospective study is to suggest the possibility of laparoscopy‐assisted gastrectomy (LAG) for advanced gastric cancer (AGC) through long‐term outcomes.MethodsOf 283 patients with gastric cancer who underwent LAG with extraperigastric (D2) lymphadenectomy between January 2004 and February 2009, 106 were pathologically confirmed with AGC and analyzed.ResultsThere were 75 men and 31 women, with a mean age of 61.4 ± 11.7 years. There were 32 total gastrectomies and 74 distal gastrectomies with D2 lymphadenectomy. The mean tumor size was 4.8 ± 2.6 cm. The mean numbers of retrieved and metastatic lymph nodes were 34.3 ± 15.3 and 5.4 ± 8.7, respectively. There was no lymph node metastasis in 44 patients (41.5%), and there were 35 grade T2a, 51 T2b, and 20 T3 lesions. There were 10 operation‐related morbidities (9.4%) and one postoperative death (0.9%) from hepatic failure. The overall and disease‐free survival rates were 81.4% and 72.4%, respectively. Tumors recurred in 17 patients (16.0%) during the follow‐up periods (median 21.5 months; range 2–60).ConclusionsLAG for AGC might be considered as a minimally invasive treatment in selected cases, but further study comparing it with open gastrectomy will be needed. J. Surg. Oncol. 2009;100:693–698. © 2009 Wiley‐Liss, Inc.
The effects of ultra low fluence rate single and repetitive photodynamic therapy on glioma spheroids
Authors: Mathews Marlon S. , Angell‐Petersen Even , Sanchez Rogelio , Sun Chung‐Ho , Vo Van , Hirschberg Henry , Madsen Steen J. 
Published: September 2009

AbstractBackground and ObjectiveAchieving local control of gliomas with photodynamic therapy (PDT) requires the delivery of adequate light fluences to depths of 1–2 cm in the resection margin where the majority of local recurrences originate. This is clinically impractical with current single‐shot, intraoperative PDT treatments due to the length of time required to deliver adequate fluences. Multiple or extended treatment protocols would therefore seem to be required. The response of human glioma spheroids to 5‐aminolevulinic acid (ALA)‐mediated PDT using single or, repetitive light delivery protocols was investigated at both low and ultra low fluence rates.Study Design/Materials and MethodsHuman glioma spheroids (400 µm diameter) were subjected to sub‐threshold light fluence (1.5, 3, or 6 J cm−2) ALA–PDT consisting of four light delivery schemes: single treatment given over either 1 or 24 hours, repetitive treatment given either as four 1 hour light treatments separated by a 4 day interval, or 24 hours light delivery, consisting of four 24 hours treatments separated by a 3 day interval. Treatment efficacy was evaluated using a growth assay. In some cases, confocal microscopy was used to image cell viability.ResultsThe repetitive and single light treatment protocols were most effective when delivered at ultra low (µW cm−2) fluence rates. In all cases, growth inhibition was light dose‐dependent. The repetitive ultra low fluence rate treatment (1.5 J cm−2; irradiance = 17 µW cm−2) light delivery protocol was the most effective resulting in total growth inhibition during the 2‐week observation period.ConclusionUltra low light fluence rate ALA–PDT results in significant spheroid growth inhibition. Repeated administration of ALA was required during repetitive and/or protracted single PDT treatment protocols. The existence of a lower fluence rate limit, below which the efficacy of threshold light fluences diminish was not found in these studies. Lasers Surg. Med. 41:578–584, 2009. © 2009 Wiley‐Liss, Inc.
Neoglycopolymers Based on 4‐Vinyl‐1,2,3‐Triazole Monomers Prepared by Click Chemistry
Authors: Hetzer Martin , Chen Gaojian , Barner‐Kowollik Christopher , Stenzel Martina H. 
Published: September 2009

AbstractThe synthesis of a new glycomonomer based on mannose, prepared via CuAAC, is reported. The resulting 1,2,3‐triazole linkage between mannose and the polymer backbone ensures the formation of highly stable glycopolymers, which will not undergo hydrolysis. The monomer 2′‐(4‐vinyl‐[1,2,3]‐triazol‐1‐yl)ethyl‐O‐α‐D‐mannopyranoside was polymerized in the presence of a RAFT agent – 3‐benzylsulfanylthiocarbonylsulfanyl propionic acid – to yield well‐defined polymers with molecular weights up to 51 500 g mol−1 and a PDI of 1.16. The resulting polymer was employed as a macroRAFT agent in the polymerization of NIPAAm in order to generate thermo‐responsive block copolymers, which undergo reversible micelle formation at elevated temperatures. The rapid interaction between the polymers prepared and ConA confirms the high affinity of these structures to proteins. While the linear glycopolymers already undergo a fast complexation with ConA, the reported rates have found to be exceeded by the micellar glycopolymer structure presented in the current contribution.magnified image