bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract PO3-01-08: Interaction of Prior Chemotherapy and Addition of Ovarian Function Suppression on Menopausal Symptoms in Tamoxifen-Treated Breast Cancer Patient: A prospective, Observational study
Authors: Lee Youngwon , Lee Jong Won , Lee Sae Byul , Son Byung Ho , Kim Hee Jeong , Ko Beom Seok , Kim Jisun , Chung Il-Yong , Yoo Tae-Kyung 
Published: May 2024

Abstract
Background: Adjuvant endocrine therapy (AET) is commonly used for hormone receptor-positive breast cancer patients. Combining ovarian function suppression (OFS) with tamoxifen improves survival outcomes, but is associated with menopausal symptom-related issues and treatment discontinuation. This study aimed to compare menopausal symptoms between tamoxifen alone and tamoxifen plus OFS over 12 months and identify related factors. Methods: This prospective study included 209 premenopausal breast cancer patients on tamoxifen. Menopausal symptoms were assessed using the Menopausal Rating Scale (MRS) at baseline, 3, 6, and 12 months. Statistical analysis involved linear regression and generalized estimating equations. Results: Of the participants, 27.8% received tamoxifen plus OFS and were younger and more likely to be unmarried. The tamoxifen plus OFS group had lower baseline MRS scores, but higher scores at 6 and 12 months compared to tamoxifen alone. MRS scores increased significantly in both groups, plateauing at 6 months with tamoxifen alone and at 12 months with tamoxifen plus OFS. Factors associated with higher MRS scores at 6 months were baseline MRS scores and addition of OFS. Impact of OFS on MRS scores varied with prior chemotherapy status, being significant in patients without prior chemotherapy. Conclusion: Adding OFS to tamoxifen in premenopausal breast cancer patients was associated with a higher burden of menopausal symptoms compared to tamoxifen alone, particularly in patients who have not undergone prior chemotherapy. Therefore, careful consideration and decision-making regarding this issue are crucial in terms of both treatment outcomes and quality of life.
Table 1. Baseline characteristics, Overall and According to adjuvant endocrine therapy, tamoxifen alone versus tamoxifen plus ovarian function suppression (OFS)
Table 2. Multivariable linear regression about MRS scores from the baseline to 6 months, and with interaction between addition of OFS and prior chemotherapy effect
Table 3. Interaction effect of additional OFS depending on prior chemotherapy; (a) without prior chemotherapy, (b) with prior chemotherapy
Citation Format: Youngwon Lee, Jong Won Lee, Sae Byul Lee, Byung Ho Son, Hee Jeong Kim, Beom Seok Ko, Jisun Kim, Il-Yong Chung, Tae-Kyung Yoo. Interaction of Prior Chemotherapy and Addition of Ovarian Function Suppression on Menopausal Symptoms in Tamoxifen-Treated Breast Cancer Patient: A prospective, Observational study [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO3-01-08.
Abstract PO3-07-12: Effect of neoadjuvant chemotherapy on peritumoral edema in early stage breast cancer and its prognostic value
Authors: Shigematsu Hideo , Fujimoto Mutsumi , Kobayashi Yoshie , Yoshiyama Tomoyuki , Matsuura Noriaki , Komoto Daisuke , Kuraoka Kazuya 
Published: May 2024

Abstract
Objectives: We aimed to evaluate the effect of neoadjuvant chemotherapy (NAC) on peritumoral edema (PE) and its prognostic value in operable breast cancer.
Materials & Methods: This retrospective study included 128 cT1-4N0-3M0 breast cancer patients who underwent contrast-enhanced magnetic resonance imaging (MRI) of the breast before and after anthracycline- and/or taxane-based NAC, followed by curative surgery at our hospital, between 2006 and 2016. T2-weighted MRI revealed PE, and PE before NAC (pre-PE) and PE after NAC (residual PE) were evaluated. The correlation between the presence or absence of PE and relapse-free survival was evaluated using a log-rank test and multivariable Cox regression analysis. The risk of recurrence was stratified according to the residual cancer burden (RCB).
Results: Pre-PE was observed in 64 out of 128 patients (50%). Among 64 patients with pre-PE-positive breast cancer, residual PE was observed in 21 (32.8%). In the log-rank test, breast cancer with residual PE had a poorer prognosis than breast cancer with PE that had disappeared (p &lt; 0.0001). In the multivariable Cox regression analysis, residual PE was a significant factor of poor prognosis (RR, 20.5; 95% confidence interval, 5.3–108.2; p &lt; 0.0001). Regarding RCB stratification, compared to patients with breast cancer with disappeared PE, those with breast cancer with residual PE exhibited significantly poor prognosis in class II and class III (p = 0.006, 0.02).
Conclusion: In breast cancer with PE, residual PE after NAC is a significant factor related to poor prognosis.
Effect of neoadjuvant chemotherapy on peritumoral edema in patients with breast cancer and its clinical significance
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Citation Format: Hideo Shigematsu, Mutsumi Fujimoto, Yoshie Kobayashi, Tomoyuki Yoshiyama, Noriaki Matsuura, Daisuke Komoto, Kazuya Kuraoka. Effect of neoadjuvant chemotherapy on peritumoral edema in early stage breast cancer and its prognostic value [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO3-07-12.
Abstract PO3-10-06: Parenting While Living with Cancer - Providing Better Outcomes for Families During the Cancer Journey
Authors: Kabir Alicia 
Published: May 2024

Abstract
For over 20 years, Kesem has been dedicated to supporting children impacted by a parent’s cancer. To better understand the stresses on a family navigating cancer, Kesem completed a several month research program rooted in Diversity, Equity, and Inclusion (DEI) and consisting of ethnographic research, quantitative surveys, focus groups, benchmarking, and data analytics. We are using this research to develop a deeper understanding of the personal stories of families impacted by a cancer diagnosis and of the current data from experts in the field. Kesem is sharing our research findings in order for the general oncology space to better serve parents living with cancer.
The research included three weeks of ethnographic research completed in rural Mississippi, the Pacific Northwest, and southern Nevada. The research team completed 124 interviews in 18 cities, gathering deep insights about being a parent while living with cancer. The team also reviewed over 30 databases and conducted a survey of approximately 150 parents with cancer.
Little has been published about parental cancer in the past decade. Using literature reviews and data such as the 2020 decennial census, we have been able to generate a more accurate assessment of need than ever, confirming earlier estimates that there are approximately five million children in the United States who have a parent with cancer. This means that the average percentage of children under 18 who have experience with parental cancer is between 3.6%–5.5%.
The following key takeaways from this research are helpful for all who support patients, including oncologists, nurse navigators, and patient advocates:
Based on this research and our ongoing internal survey results, we know that patients generally have less anxiety when they know their children will receive a lifetime of support. Children who are supported are more likely to create a community of support for themselves, do better academically, and have increased mental health. This leads to better outcomes for the entire family.
Citation Format: Alicia Kabir. Parenting While Living with Cancer - Providing Better Outcomes for Families During the Cancer Journey [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO3-10-06.
Abstract PO3-12-04: Pulmonary Complication related to Trastuzumab Deruxtecan. A pharmacovigilance study from 2022-2023 FAERS Database
Authors: Neupane Niraj , Kharel Himal , Thapa Sangharsha 
Published: May 2024

Abstract
Background: The horizon of Trastuzumab Deruxtecan (T-DXd), an antibody-drug conjugate, has been expanding. After its promising results in HER2-positive/HER2-low Breast cancer, it has been on trial for other cancers, such as HER2-negative breast cancers, Gastrointestinal, lung, colorectal, urothelial, etc., and it has shown promising results in clinical trials. However, there have been reports of pulmonary adverse events associated with T-DXd, including interstitial lung disease (ILD) and pneumonitis. Understanding the occurrence and characteristics of these pulmonary complications is essential for optimizing patient care and ensuring the safe use of T-DXd. Using the FAERS (FDA Adverse Event Reporting System) database for 2022-2023 aims to see T-DXd-related pulmonary complications and guide healthcare professionals in monitoring and managing these adverse events effectively. Methods: We conducted a retrospective analysis of all reported cases of respiratory complications in patients using TDXD, utilizing data reported to the FDA Adverse Event Reporting System (FAERS) database for January 2022 to March 2023. We included patients of more than 18; these cases were identified and classified using the Medical Dictionary for Regulatory Activities (MedDRA) terminology. Results: In this study, a total of 296 cases of adverse events were reported in patients using TDXD. Among these cases, 74 (27%) were respiratory adverse events. The most frequently observed respiratory complications were interstitial lung disease (ILD) and pneumonitis, with 21 cases each, accounting for 56% of the total respiratory complications. Out of the 14 reported deaths in this cohort, pneumonitis was the most commonly seen respiratory complication, occurring in 8 patients, followed by pulmonary embolism and ILD, each reported in 4 patients. Conclusion: Respiratory complications were the most frequent among the reported adverse events, accounting for 27% of all cases. ILD and pneumonitis were the most common complications, with 14 deaths reported in this group. These findings underline the importance of closely monitoring and managing pulmonary adverse events in patients treated with T-DXd. Healthcare professionals can use this information to optimize patient care and ensure the safe use of T-DXd. However, it is important to note that this study was based on a database and has limitations such as underreporting bias and lack of a control group, which hinders establishing a causal relationship. Additional research is needed to identify risk factors and improve patient outcomes.
Citation Format: Niraj Neupane, Himal Kharel, Sangharsha Thapa. Pulmonary Complication related to Trastuzumab Deruxtecan. A pharmacovigilance study from 2022-2023 FAERS Database [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO3-12-04.
Abstract PO3-16-09: Real-World Experience with Trastuzumab Deruxtecan at a Diverse NCI Comprehensive Cancer Center
Authors: Meisel Jane , Ratcliffe Maisey 
Published: May 2024

Abstract
Background: Trastuzumab Deruxtecan (T-DXd) is an antibody-drug conjugate originally approved for use in patients with HER2–positive metastatic breast cancer (MBC). In June 2022, data from the DESTINY-Breast04 trial revealed a near-doubling of progression-free survival (PFS) and significantly improved overall survival (OS) for patients with HER2-low MBC (immunohistochemistry [IHC] grade 1+ or IHC2+ in situ hybridization [ISH]-negative) treated with T-DXd versus standard-of-care chemotherapy. The data from this clinical trial led to the approval of T-DXd for use in patients with HER2-low MBC. However, the DESTINY-Breast studies completed to date have included &lt; 5% black patients. This retrospective study of patients at a racially diverse NCI Comprehensive Cancer Center was designed to study whether T-DXd in a real-world population are comparable to published data. Methods: A retrospective chart review was conducted and identified 72 patients with HER2-low and HER2-positive MBC who received T-DXd between December 2019 and March 2023 at the Winship Cancer Institute at Emory University. Data collected for all patients included demographics, prior breast cancer history, T-DXd -specific and post-T-DXd treatment, and clinical outcomes where applicable. Results: Of the 103 patients who were dosed with T-DXd, 55 (53.4%) had HER2-positive disease, and 48 (46.7%) patients had HER2-low disease. 71 (68.9%) patients had hormone-receptor positive disease and 32 (31.1%) patients had hormone-receptor negative disease. The overall study population was 46% Caucasian; 38% African American; 13% Asian; 4% Unreported. The average number of cycles received was 11 (on treatment an average of 8 months). Pneumonitis occurred in 5 patients (4.9%). HER2-positive patients were typically on T-Dxd for a greater number of cycles than HER2-low patients (Table 1). Additionally, patients with brain metastases were, on average, treated with T-Dxd longer than patients without brain metastases, 14.5 versus 9 cycles. The number of cycles of T-Dxd received, the need for dose reduction, and incidence pneumonitis did not differ significantly between black and white patients. The data for this study is preliminary 48% of the patient population are still actively undergoing T-Dxd treatment. Conclusion: This study reviewed and analyzed T-Dxd treatment in a diverse population of both HER2-positive and HER2-low MBC patients, and in this study, outcomes of treatment did not differ by race. More attention to this topic is needed in future studies of larger populations, along with increased efforts to enroll diverse patient populations in clinical trials.
Table 1.
Citation Format: Jane Meisel, Maisey Ratcliffe. Real-World Experience with Trastuzumab Deruxtecan at a Diverse NCI Comprehensive Cancer Center [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO3-16-09.
Abstract PO3-18-07: Therapeutic Potential of Combining Eltanexor with Tamoxifen to Treat Primary and Metastatic Estrogen Receptor Positive (ER+) Breast Cancers
Authors: Jain Vedant , Kamdar Myra , McGee Hannah , Zuo Qianying , Yoo Jin Young , Landesman Yosef , Walker Christopher , Madak-Erdogan Zeynep 
Published: May 2024

Abstract
Estrogen receptors are key pathway initiators in the aggressive development of more than two-thirds of all breast cancers. Tamoxifen (TAM) is a selective estrogen receptor modulator that disables the ER pathway and inhibits the progression of ER+ breast cancer. Unfortunately, 10-40% of patients with ER+ breast cancer who were treated with TAM experience recurrence and metastasis within 10 years. We have previously identified exportin 1 (XPO1) to be more highly expressed in breast cancers with acquired TAM resistance compared to TAM-sensitive counterparts and showed that a combination treatment of TAM with an XPO1 inhibitor, selinexor, is an effective method of tumor suppression in preclinical models. In this study we investigated the activity of eltanexor, an investigational second generation XPO1 inhibitor with minimal penetration of the blood-brain barrier, to inhibit cancer growth without leading to weight loss. Our results show that mice harboring MCF7-ESR1Y537Sxenograft tumors had significantly less (P &lt; .05) flank tumor growth when administered a treatment regimen of TAM and eltanexor compared to control mice. In metastatic tumor models, we observed decreased metastatic burden in mice harboring MCF7-ESR1 D538G and MCF7-ESR1Y537S tumors when co-administered TAM and eltanexor. We did not observe weight changes in either model. Our findings suggest that eltanexor may be a relevant treatment for further exploration in the context of a TAM combination therapy for treatment of ER+ breast cancer.
Citation Format: Vedant Jain, Myra Kamdar, Hannah McGee, Qianying Zuo, Jin Young Yoo, Yosef Landesman, Christopher Walker, Zeynep Madak-Erdogan. Therapeutic Potential of Combining Eltanexor with Tamoxifen to Treat Primary and Metastatic Estrogen Receptor Positive (ER+) Breast Cancers [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO3-18-07.
Abstract PO3-22-12: Clinical feasibility of nipple sparing mastectomy (NSM) followed by immediate reconstruction based on direct-to-implant technique
Authors: Toh Uhi , Takao Yuko , Katagiri Yuriko , Sugihara Rie , Watanabe Hidetaka 
Published: May 2024

Abstract
[Background] The development of NSM approach combined with immediate implant-based breast reconstruction (IBBR) for patients with earlystage breast cancer (BC) preserve the natural skin envelope including nipple-areolar complex (NAC) to able to immediately reconstruct the breast with a permanent implant and simultaneously omit the skin expansion with a tissue expander. We retrospectively analyzed the clinical results of NSM+IBBR and compared the complication rate, outcome of patients who underwent immediate (one-stage) or delayed (two-stage) IBBR followed by standard TM or NSM.
[Patients and Results] A total of 108 patients who underwent a TM that included SSM or NSM followed by one- or two-stage IBBR between January 2013 and April 2022. 53 patients underwent a total mastectomy (TM) and 32 patients underwent an NSM followed by two-stage IBBR, and 24 patients underwent an NSM followed by one-stage IBBR. The operation times were 236, 247.2, and 321 min, and the mean surgical bleeding was 60.4, 88.8, and 138 ml, respectively. The complications in the three groups included infection (2.7%, 11.1%, and 6.3%), seroma/hematoma (0%, 5.6%, and 6.3%), flap necrosis (2.7%, 11.1%, and 12.5%), and loss of tissue expander or implant (2.7%, 5.6%, and 6.3%), respectively. At the median 62-month follow-up after the NSM + IBBR, one patient was diagnosed with distant lymph node metastases at the 24-month follow-up and one patient had new primary breast cancer within the reconstructed breast at the 38-month follow-up. But no loco-regional recurrence at the NAC or other distant recurrence were detected in the patients undergone regardless TM or NSM + one-stage or two-stage IBBR.
[Summary] Our results suggested that the use of one-stage IBRR tended to increase the operating time and the amount of bleeding compared to two-stage IBRR and the complication rate might be higher in cases in which an NSM is followed by IBBR. Oncological outcome was consistent with the studies showing that loco-regional recurrence is less likely at the NAC regardless of whether the patients underwent one-stage or two-stage IBBR following an NSM.
Citation Format: Uhi Toh, Yuko Takao, Yuriko Katagiri, Rie Sugihara, Hidetaka Watanabe. Clinical feasibility of nipple sparing mastectomy (NSM) followed by immediate reconstruction based on direct-to-implant technique [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO3-22-12.
Abstract PO3-28-03: Mitigating Financial Toxicity Through Individualized Education
Authors: Doran Joanna , Bryant Monica 
Published: May 2024

Abstract
Background Triage Cancer® offers a free Legal & Financial Navigation Program (LFN) that supports individuals coping with cancer, their caregivers, and health care providers as they navigate the legal and practical matters that arise after a diagnosis. Without access to the proper resources, individuals impacted by cancer may suffer the financial burden of a diagnosis – or financial toxicity, as coined by researchers at Duke. Financial toxicity has proven to have a negative impact on quality of life and mental and physical health of individuals coping with cancer. The LFN provides individuals impacted by a diagnosis with the accurate information and resources needed to help mitigate financial toxicity. The LFN addresses the gap in education around cancer-related legal issues to improve the overall health of individuals coping with cancer. This tailored education is particularly important for providers, as there is a significant lack of training around cancer-related legal issues. Consequently, health care providers are often not equipped to answer their patient’s complex questions about cancer-related legal issues, including health insurance, disability insurance, and employment. The LFN provides personalized education on relevant laws and actionable steps to navigate the situation, which improves the provider’s ability to support their patients and the patients’ ability to self-advocate. Methods To start the process, individuals complete a brief intake form online and schedule a call with the staff. During the call, the staff provides education around relevant laws and practical options to manage the situation. The efficacy of the program is measured through voluntary survey response. Callers receive a follow-up email with a one question survey within a day of the initial call. After three weeks, the caller also receives a detailed survey. Results In 2022, Triage Cancer® provided direct consultation to 1,289 callers; 384 with breast cancer. For those callers, the most common topics included: employment, disability insurance, and health insurance. Survey data indicates that after speaking with staff, 93% felt better prepared with regard to their options and 94% agreed that they had actionable next steps. Conclusion The LFN provides tailored education around cancer-related legal issues in order to improve the quality of life of individuals coping with cancer. The LFN provides accurate information on relevant laws and actionable steps to help individuals make informed decisions to mitigate financial toxicity.
Citation Format: Joanna Doran, Monica Bryant. Mitigating Financial Toxicity Through Individualized Education [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO3-28-03.