bluuebunny/crossref_metadata_2025_split huggingface dataset:
Upregulation of miR‐650 is correlated with down‐regulation of ING4 and progression of hepatocellular carcinoma
Authors: Zeng Zhao‐lin , Li Fu‐jun , Gao Feng , Sun Dong‐sheng , Yao Lei 
Published: July 2012

AbstractBackgroundIn the last decade, studies in hepatocellular carcinoma (HCC) demonstrate dysregulation of miRNAs expression. For instance, miR‐650 has been implicated in gastric and colorectal cancer tumorigenicity; however, the role of miR‐650 remains unknown in HCC.MethodsIn this study, we performed a comprehensive analysis to examine the miR‐650 expression level in 248 HCC and 120 paracarcinomatous liver (PCL) tissues. The correlations between miR‐650 expression level and the clinicopathological characteristics (HCC tumorigenicity) were evaluated. The role of miR‐650 played in HCC was investigated by Q‐PCR, western blot, and MTT.ResultsWe found that miR‐650 expression was significantly increased in HCC patients and significantly associated with the patients' age (P = 0.0019), differentiation capability (P = 0.0108), and also tumor stage (P = 0.0069). Moreover, we compared the expression level of both ING4 and miR‐650 in 122 HCC patients by western blot and real‐time PCR. Statistical result showed a significant negative correlation between them (rs = −0.2011, P = 0.0264). Transfection and MTT test suggested that miR‐650 decreased the expression of ING4 and stimulate liver cells proliferation significantly.ConclusionThese data suggested that miR‐650 is correlated with the pathogenesis of HCC and is involved in the HCC tumorigenesis process by inhibiting the expression of ING4. J. Surg. Oncol. 2013;107:105–110. © 2012 Wiley Periodicals, Inc.
Diagnostic adequacy of surgeon‐performed ultrasound‐guided fine needle aspiration biopsy of thyroid nodules
Authors: Karadeniz Cakmak Guldeniz , Emre Ali U. , Tascilar Oge , Gultekin Fatma A. , Ozdamar Sukru O. , Comert Mustafa 
Published: July 2012

AbstractBackgroundSurgeon‐performed ultrasonography (US) of thyroid nodules might serve as a potential therapeutic guide to designate accurate surgical or clinical intervention.ObjectiveTo evaluate the diagnostic adequacy of surgeon‐performed ultrasonography guided fine needle aspiration biopsy (FNAB) of thyroid nodules, the factors responsible for diagnostic adequacy and the impact of surgeon‐performed US on treatment approach.MethodsRetrospective review of a single surgeon performed 621 US‐guided FNABs without on‐site cytological specimen assessment. Outside US findings were compared to the surgeon‐performed US. Measured variables and outcomes for the study included diagnostic adequacy rates and the effects of detected differences between US reports on treatment variability.ResultsDiagnostic adequacy rate of surgeon‐performed US‐guided FNAB was determined to be 94.52% without on‐site specimen evaluation by cytologist. Non‐diagnostic specimens occurred in 34 of 621 (5.48%) nodules. The differences detected between the outside US and surgeon‐performed US altered invasive treatment algorithm in 30 (5.47%) patients. FNAB was avoided for 15 (2.7%) patients. Total thyroidectomy became the preferred surgical option in 15 (2.7%) patients after the discovery of additional nodules in the contralateral lobe.ConclusionSurgeon‐performed US offers clear clinical benefits in terms of diagnostic yield of FNAB with providing valuable additional data that might alter surgical treatment approach. J. Surg. Oncol. 2013;107:206–210. © 2012 Wiley Periodicals, Inc.
Flows in networks with delay in the vertices
Authors: Bayazit F. , Dorn B. , Rhandi A. 
Published: July 2012

AbstractOur goal is to show asynchronous exponential growth (AEG) for a flow in a network with delay in the vertices. For this purpose we show first that its wellposedness can be characterized via an appropriate operator being the generator of a strongly continuous semigroup. We investigate the long term behavior of the system via the spectrum of this generator using techniques from operator matrices, Hille‐Yosida operators and positive semigroups. Finally, we apply our results to deduce that our problem has (AEG).
Equilibrium problem for the eigenvalues of banded block Toeplitz matrices
Authors: Delvaux Steven 
Published: July 2012

AbstractWe consider banded block Toeplitz matrices Tn with n block rows and columns. We show that under certain technical assumptions, the normalized eigenvalue counting measure of Tn for n → ∞ weakly converges to one component of the unique vector of measures that minimizes a certain energy functional. In this way we generalize a recent result of Duits and Kuijlaars for the scalar case. Along the way we also obtain an equilibrium problem associated to an arbitrary algebraic curve, not necessarily related to a block Toeplitz matrix.For banded block Toeplitz matrices, there are several new phenomena that do not occur in the scalar case: (i) The total masses of the equilibrium measures do not necessarily form a simple arithmetic series but in general are obtained through a combinatorial rule; (ii) The limiting eigenvalue distribution may contain point masses, and there may be attracting point sources in the equilibrium problem; (iii) More seriously, there are examples where the connection between the limiting eigenvalue distribution of Tn and the solution to the equilibrium problem breaks down. We provide sufficient conditions guaranteeing that no such breakdown occurs; in particular we show this if Tn is a Hessenberg matrix.
The Effect of Scarcity on the Purchase Intentions of Prevention and Promotion Motivated Consumers
Authors: Ku Hsuan‐Hsuan , Kuo Chien‐Chih , Kuo Tzu‐Wei 
Published: July 2012

AbstractThis study investigates the influence of consumers’ motivational orientations (“prevention” vs. “promotion”) on their susceptibility to demand‐based versus supply‐based scarcity, measured by purchase intention scores. Prevention‐focused participants were more inclined to adopt a product when it was perceived to be demand‐scarce rather than supply‐scarce, while those who were identified as promotion‐focused responded positively to scarcity attributed to supply shortfall. In addition, products that could be associated with a prevention motive enhanced purchase intentions when presented as demand‐scarce but not if perceived to be supply‐scarce; conversely, products associated with the promotion motive scored better if the scarcity was seen to be supply‐generated rather than demand‐generated. Lastly, messages focused on prevention were more effective than those focused on promotion in the case of perceived demand scarcity, whereas the converse holds true for supply scarcity. These findings highlight the importance of understanding the motivational differences underlying the effectiveness of scarcity appeals. They furthermore suggest the strategic implication that improved intention to purchase occurs when the regulatory focus evoked by a scarcity‐related message is compatible with the appeal it communicates.
How Attachment Affects the Strength of Peer Influence on Adolescent Consumer Behavior
Authors: Huang Yunhui , Wang Lei , Shi Junqi 
Published: July 2012

ABSTRACTThis research examined how attachment affected the peer influence on adolescent consumer behavior. Results showed that attachment toward family and toward peers emerged together. Adolescent attachment anxiety strengthened the peer influence in consumption while attachment avoidance weakened the peer influence. Anxiety was positively related to adolescents’ perception of friends’ greater knowledge, spending when shopping with friends, and motivation to comply with friends’ suggestions on purchases directly and indirectly through consumer susceptibility to informational and normative influence. In contrast, attachment avoidance decreased the tendency to shop often with friends and the motivation to comply in a purchase. This study revealed that the influence of individual attachment orientations on interpersonal relationships can be extended to the field of consumption.
A Personality‐Competence Model of Opinion Leadership
Authors: Gnambs Timo , Batinic Bernad 
Published: July 2012

ABSTRACTOpinion leaders constitute a central consumer segment for targeted marketing strategies. By separating opinion leadership into a generalized and domain‐specific component, this study examines the psychological profile of N = 417 consumers from Germany and incorporates opinion leadership into a hierarchical framework of human personality. Results emphasize two major sources of domain‐specific opinion leadership (DSOL): personality in the form of a general, domain‐independent influencer trait and competencies in terms of product‐specific knowledge. Moreover, the study highlights a number of traits including the Big Five of personality, typical intellectual engagement, and general self‐efficacy that form a distinct personality profile of DSOL. The effects of these personality traits on DSOL are partially mediated by generalized opinion leadership and objective knowledge.
Decomposition‐Assembly of Tetraphenylethylene Nanoparticles With Uniform Size and Aggregation‐Induced Emission property
Authors: Wang Tianxiang , Cai Yunbo , Wang Zhipeng , Guan Erjia , Yu Dahai , Qin Anjun , Sun Jingzhi , Tang Ben Zhong , Gao Changyou 
Published: July 2012

AbstractTetraphenylethylene (TPE)‐substituted poly(allylamine hydrochloride) (PAH‐g‐TPE) is synthesized by a Schiff base reaction between PAH and TPE‐CHO. The PAH‐g‐TPE forms micelles in water at pH 6, which are further transformed into pure TPE‐CHO nanoparticles (NPs) with a diameter of ≈300 nm after incubation in a solution of low pH value. In contrast, only amorphous precipitates are obtained when TPE‐CHO methanol solution is incubated in water. The aggregation‐induced emission feature of the TPE molecule is completely retained in the TPE NPs, which can be internalized into cells and show blue fluorescence. Formation mechanism of the TPE NPs is proposed by taking into account the guidance effect of linear and charged PAH molecules, and the propeller‐stacking manner between the TPE‐CHO molecules.
Application of GQSAR for Scaffold Hopping and Lead Optimization in Multitarget Inhibitors
Authors: Ajmani Subhash , Kulkarni Sudhir A. 
Published: July 2012

AbstractMany literature reports suggest that drugs against multiple targets may overcome many limitations of single targets and achieve a more effective and safer control of the disease. However, design of multitarget drugs presents a great challenge. The present study demonstrates application of a novel Group based QSAR (GQSAR) method to assist in lead optimization of multikinase (PDGFR‐beta, FGFR‐1 and SRC) and scaffold hopping of multiserotonin target (serotonin receptor 1A and serotonin transporter) inhibitors. For GQSAR analysis, a wide variety of structurally diverse multikinase inhibitors (225 molecules) and multiserotonin target inhibitors (162 molecules) were collected from various literature reports. Each molecule in the data set was divided into four fragments (kinase inhibitors) and three fragments (serotonin target inhibitors) and their corresponding two‐dimensional fragment descriptors were calculated. The multiresponse regression GQSAR models were developed for both the datasets. The developed GQSAR models were found to be useful for scaffold hopping and lead optimization of multitarget inhibitors. In addition, the developed GQSAR models provide important fragment based features that can form the building blocks to guide combinatorial library design in the search for optimally potent multitarget inhibitors.
A Systematic Review of Imaging Modalities in the Diagnosis of Greater Trochanteric Pain Syndrome
Authors: McMahon Samuel E. , Smith Toby O. , Hing Caroline B. 
Published: July 2012

AbstractObjectivesTo identify the most effective imaging modality in the investigation of greater trochanteric pain syndrome (GTPS).MethodsA narrative review of the available literature was conducted. A total of 326 studies were identified by a literature search, ten of which were included for review. Seven studies investigated magnetic resonance imaging (MRI), one ultrasound scan (USS), one plain radiography and one bone scintigraphy.ResultsOn analysis, MRI was found consistently to have the highest correlation with clinical and intraoperative findings. USS and plain radiography provided encouraging results. However, conclusions drawn from this were limited by the paucity of data.ConclusionsThe study provided encouraging results, although conclusions drawn from them were limited by the paucity of data. We believe that MRI should be the current investigation of choice for GTPS. However, further study is required in the form of multicentre, randomized controlled trials to confirm the validity of the conclusions presented here. Copyright © 2012 John Wiley & Sons, Ltd.
On a new edge‐based gradient recovery technique
Authors: Pouliot B. , Fortin M. , Fortin A. , Chamberland É. 
Published: July 2012

SUMMARYA posteriori error estimation methods for mesh adaptation often require an accurate computation of the gradient of a Lagrange finite element solution. The precision of the error estimation is directly related to the accuracy of the recovered gradient. We therefore present in this communication a simple method for the evaluation of the gradient of a linear Lagrange finite element solution, and we show that it has significant advantages over existing methods of the same order. The proposed method requires the solution of a global linear system that can be solved by a preconditioned conjugate gradient method. An interesting feature is that it does not require any special treatment for boundary nodes contrarily to classical local patch recovery methods. Copyright © 2012 John Wiley & Sons, Ltd.
Finite‐volume stress analysis in multi‐material linear elastic body
Authors: Tuković Ž. , Ivanković A. , Karač A. 
Published: July 2012

SUMMARYCorrect calculation of stresses at the interface of bonded or otherwise joined materials plays a significant role in many applications. It is therefore important that traction at the material interface is calculated as accurately as possible. This paper describes procedures that can be employed to achieve this goal by using centre‐based finite‐volume method. Total traction at the interface is calculated by decomposing it into normal and tangential components, both being calculated at each side of the interface, and applying the continuity assumption. The way in which the traction approximation is achieved depends on calculation of tangential gradient of displacement at the interface. To this end, three different methods are proposed and validated against problems with known solutions. It was shown that all methods can be successfully used to simulate problems with multi‐material domains, with the procedure based on finite area method being most accurate. Copyright © 2012 John Wiley & Sons, Ltd.
An embedded formulation with conforming finite elements to capture strong discontinuities
Authors: Dias‐da‐Costa D. , Alfaiate J. , Sluys L.J. , Areias P. , Júlio E. 
Published: July 2012

SUMMARYThe embedding of discontinuities into finite elements has become a powerful technique for the simulation of fracture in a wide variety of mechanical problems. However, existing formulations still use non‐conforming finite elements. In this manuscript, a new conforming formulation is proposed. The main properties of this formulation are as follows: (i) variational consistency; (ii) no limitations on the choice of the parent finite element; (iii) comprehensive kinematics of the discontinuity, including both rigid body motion and stretching; (iv) fully compatible enhanced kinematic field; (v) additional global DOFs located at the discontinuity; (vi) continuity of both jumps and tractions across element boundaries; and (vii) stress locking free. The performance of the proposed formulation is tested by means of academic and structural examples. The numerical results are compared with available experimental results and other numerical approaches, namely the generalized strong discontinuity approach and the generalized FEM/Extended FEM. Copyright © 2012 John Wiley & Sons, Ltd.
Mechanical and thermal studies on epoxy toluene oligomer‐modified epoxy resin/marble waste composites
Authors: Ahmetli Gulnare , Kocak Nuriye , Dag Mustafa , Kurbanli Refika 
Published: July 2012

AbstractIn this research, marble dust waste was recycled as raw material for the preparation of composite materials. Epoxy toluene oligomer (ETO) was synthesized from toluene and epichlorohydrin, which was used as a comatrix in 50 wt% with commercial epoxy resin (ER). Its chemical structure was characterized with Fourier transform infrared spectroscopy and chemical analyses. The rigid filler used in epoxy polymer matrix was the marble processing waste obtained from wastewater using different coagulants, such as sepiolite, zeolite, or pumice. The thermal and mechanical properties of the composites were evaluated with thermogravimetric and mechanical analyses. The results showed that the marble wastes with all coagulants can significantly improve the thermal stability of an ER–ETO matrix at temperatures above 350°C. Composites exhibited a higher thermal degradation temperature with a much higher char yield. Surface hardness and tensile strength of the composites were higher than those of pure epoxy polymer matrix, as well. Scanning electron microscopy was used for the characterization of surface and cross‐sections of the composites to verify the results. POLYM. COMPOS., 2012. © 2012 Society of Plastics Engineers
Flow behavior of hydroxypropyl methyl cellulose/polyacrylic acid interpolymer complexes in aqueous media
Authors: Şakar‐Deliormanli Aylin 
Published: July 2012

AbstractThe intermolecular complexation of non‐ionic polymers with weak acids having chemically complementary structures is an important approach to modify the viscosity of polymer solutions. In this study intermolecular complexation of hydroxypropyl methyl cellulose (HPMC) with polyacrylic acid (PAA) in an aqueous medium was studied. The study focuses on the factors affecting the complexation and rheological behavior of the HPMC/PAA system including the stoichiometric ratio of the two polymers, the molecular weight of the PAA, and the pH and ionic strength of the medium. Results showed that interpolymer complexation occurred between HPMC and PAA at low pH. It was attributed to hydrogen bonding between the COOH group of the PAA and the OH group of the HPMC. Under basic conditions (above the critical pH) the viscosity of the interpolymer complex increased accompanied by a transition from a compact interpolymer complexation structure to an extended conformation of interpolymer associates. Introduction of monovalent and multivalent salts (at > pHcritical) decreased the viscosity of the HPMC/PAA interpolymer associates and favored the formation of interpolymer complexes between the two polymers. Copyright © 2012 Society of Chemical Industry
Comparing lifetime and photoluminescence imaging pattern recognition methodologies for predicting solar cell results based on as‐cut wafer properties
Authors: Sinton Ronald A. , Haunschild Jonas , Demant Matthias , Rein Stefan 
Published: July 2012

ABSTRACTWafer quality is extremely important in determining yield and efficiency of solar cells. Ideally, this wafer quality should be determined for incoming wafers before solar cell fabrication based on the electronic quality of the wafers. Recent papers have discussed methodologies for doing this by using lifetime measurement and pattern recognition of photoluminescence (PL) images. This paper compares results from quasi‐steady‐state photoconductance (QSSPC) lifetime measurements with PL imaging pattern recognition of dislocations. By using a more complete analysis of the lifetime and the PL data than performed in some recent publications, a more detailed physical picture is presented here, which reconciles contradictions between previous results. In particular, the differences between PL and QSSPC lifetime measurements on as‐cut wafers are discussed. The trends in voltage prediction based on measured lifetime, doping, and PL‐determined dislocation densities are shown. Copyright © 2012 John Wiley & Sons, Ltd.
Novel antimicrobial polyethylene composites prepared by metallocenic in situ polymerization with TiO2‐based nanoparticles
Authors: Zapata Paula A. , Palza Humberto , Delgado Katherine , Rabagliati Franco M. 
Published: July 2012

AbstractPolyethylene (PE) composites with titanium oxide (TiO2) nanoparticles were produced via in situ polymerization representing a novel route to obtain antimicrobial polymeric materials. The TiO2 nanoparticles synthesized by the sol–gel method were used either as‐synthesized or modified organically with hexadecyltrimethoxysilane (Mod‐TiO2). These particles were added, together with the catalytic system (formed by a metallocenic catalyst and methylaluminoxane as cocatalyst), directly to the reactor, yielding in situ PE composites with 2 and 8 wt % content of nanofiller. The catalytic polymerization activity presented a slight decrease with the incorporation of the TiO2 and Mod‐TiO2 nanoparticles compared to polymerization without filler. Regarding the properties of the composites, crystallinity increased slightly when the different nanofillers were added, and the elastic modulus increased around 15% compared to neat PE. PE/TiO2 nanocomposites containing 8 wt % of TiO2 exposed to UVA irradiations presented antimicrobial activity against Escherichia coli. The PE/Mod‐TiO2 nanocomposite with 8 wt % filler killed 99.99% of E. coli, regardless of light and time irradiation. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012
Revisit to the photocrosslinking behavior of PVA‐SbQ as a water‐soluble photopolymer with anomalously low contents of quaterized stilbazol side chains
Authors: Ichimura Kunihiro , Iwata Shuji , Mochizuki Shin'ya , Ohmi Mamoru , Adachi Daisaku 
Published: July 2012

AbstractThe photocrosslinking behavior of poly(vinyl alcohol) (PVA) substituted with 0.1, 0.3, 1.3, and 4.0 mol % of styrylpyridinium (SbQ) (PVA‐SbQs) side chains was reinvestigated. Even‐order derivative spectra of films of PVAs loaded with 0.1 and 0.3 mol % of SbQ revealed the presence of subpeaks owing to vibrational transitions, whereas PVA bearing 1.3 and 4.0 mol % of SbQ displayed a new blue‐shifted band (H‐band) at 328 nm due to H‐aggregation. Changes in derivative spectra disclosed the rapid disappearance of the H‐band of PVA‐SbQs under UV irradiation within exposure doses of 10 mJ cm−2. On the other hand, the films of the PVA‐SbQs were insolubilized upon UV irradiation at exposure doses of 2 and 3 mJ cm−2, respectively, leading to the conclusion that the high photosensitivity comes from the photodimerization of H‐aggregate as a ground‐state dimer. Fluorescence measurements implied the presence of J‐aggregate at 386 nm, but the involvement of the J‐aggregation in photocrosslinking was excluded because of its negligible fraction. A photosensitive emulsion of poly(vinyl acetate) emulsified with PVA‐SbQ exhibited similar changes in higher‐order derivative spectra in film and applied to fabricate a stencil for screen printing with aid of an LED‐emitting 375 nm light. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012