bluuebunny/crossref_metadata_2025_split huggingface dataset:
Imaginative appropriations of music in the new communicative scenarios
Authors: de-Aguilera-Moyano Miguel , Adell-Pitarch Joan-Elies , Borges-Rey Eddy 
Published: March 2010

Sharing music is a traditional mechanism of cultural sociability, the observation of wich is useful in order to understand the negotiation procedures of sense and identity. In the new digital scene, the act of sharing and offering music shows –along with the obvious purpose of establishing relationships with others as well as making them participate in something pleasant– a desire to spread one’s own personal taste and a will to communicate our one’s identity. Thus, now and then, communicating by means of music and sharing it –as well as giving an opinion on it– are ways of both self-representation and expression of one’s identity, offering others some sort of «musical personality»: another way of being in the world, typical of our era and related to a way of using the products of cultural industry with a personal purpose. This use, however, is not restricted to just expressing identity aspects: we use mass culture products in several ways with different purposes in our everyday life. According to some of these other uses, we will expand the field of the main subject of this article: other ways of sharing music that represent both permitted and non-permitted appropriations of music. We will accomplish this by considering some of the reasons that help getting a better understanding of the cultural task carried out by music (and other cultural products).Compartir música es un mecanismo tradicional de la sociabilidad cultural, cuya observación resulta útil para entender los mecanismos de negociación del sentido y de la identidad. En el nuevo escenario digital, el acto de compartir u ofrecer música muestra, además del evidente propósito de hacer partícipes a los otros de algo placentero y de entrar en relación, también el deseo de difundir el gusto personal y una voluntad de comunicación de la propia identidad. Así, hoy como ayer, comunicar mediante la música y compartirla –y opinar sobre la música que se comparte– son formas de auto-representación y expresión de la propia identidad, ofreciendo a los otros una especie de personalidad musical»; que es otra manera de estar en el mundo, propia de nuestra época y relacionada con un modo de usar con fines personales los productos de las industrias culturales. Aunque ese uso no se limite a la expresión de aspectos identitarios: pues nos servimos de los productos de la cultura de masas de varias maneras y con diversos fines en nuestras vidas cotidianas. En este trabajo se analizan otras formas de compartir la música, que representan modos consentidos y no consentidos de apropiación de la música. Que se completa tomando en consideración algunas de las razones que ayudan a entender cierta labor cultural que desarrollamos mediante la música y con otros elementos culturales.
The utility of musico-visual formats in teaching
Authors: Gértrudix-Barrio Manuel , Gértrudix-Barrio Felipe 
Published: March 2010

The paper discusses the educational potential of popular culture through the use didactic formats musicovisual interaction in the classroom. It is believed that popular culture, specifically music, is a particularly useful tool for learning. Considered by learning skills, and its current deployment in International educational systems. Especially, its implementation in the education Systems in Europe and Spanish. We live in a technological society, and therefore it is necessary to extend the concept of literacy to digital literacy. Elements of popular culture that are common for young people, such as video clips, should be incorporated. We analyze the competency learning proposals made by the OECD through the DESECO Project or the European framework defined by the recommendation of the European Parliament and Council. These proposals provide a starting point to establish an initial strategy, from the discursive dimension of interaction musicovisual formats, allowing for effective work in the classroom. For this reason, the article evaluates formats musico-visual interaction as teaching aids to serve a critical digital literacy. It also explores some specific contributions to the development of competencies in compulsory Secondary Education. General proposals are made to enable teachers to understand how to use these formats musico-visual interaction in their classroom to work general competencies.
Desde los presupuestos del aprendizaje por competencias, y su actual implantación en la mayor parte de los sistemas educativos internacionales, el artículo analiza la potencialidad educativa de la cultura popular a través de la utilización didáctica de los formatos de interacción músico-visual en el aula. Se defiende la necesidad de permear el concepto de alfabetización, integrando en el mismo los elementos que conforman el actual escenario de una sociedad digital altamente tecnológica, al tiempo que se recupera e inserta en el discurso de la escuela y en los procesos de aprendizaje que ésta motiva, los productos culturales que forman parte de la vivencia cotidiana de los adolescentes. El análisis de las propuestas de aprendizaje por competencias realizadas, entre otros, por la OCDE a través del Proyecto DESECO o el marco de referencia europeo definido a través de la recomendación del Parlamento y el Consejo Europeo, sirven de punto de partida para establecer una estrategia inicial que, desde la dimensión discursiva de los formatos de interacción músico-visual, permita un trabajo eficaz en el aula. Así, se evalúa la oportunidad que estos formatos de interacción músico-visual, y concretamente los videoclips, ofrecen como medios didácticos al servicio de una alfabetización digital que fomente un espíritu crítico, y se exploran algunas contribuciones concretas que se vislumbran en el desarrollo de competencias generales en Educación Secundaria Obligatoria.
The symbols and written language of users of messenger
Authors: Valencia-Cerino Yaditzy , García-Martínez Verónica 
Published: March 2010

This work presents the results of a postgraduate thesis on communication, particularly the use of language. Messenger is one of the most popular ways for communicating by signs and symbols. This study was carried out on junior high school students in state education. This research explores the possible impact on junior high school students’ written work due to their use of Messenger. To address this question, the referential communication model with the qualitative approach was used in order to carry out a comparative study. Data were gathered from 16 junior high school students between 15 and 17 years of age who were paired into two groups for each part of the investigation. The research showed that it was possible to categorize the students into three groups: those who constantly use Internet, those who do not constantly use Internet and the rest who do not use it. The end results reveal that there is little relationship between the use of signs and symbols on Messenger and the quality of written work presented by junior high school students.
El presente estudio es el resultado de un trabajo de tesis de comunicación en el que se aborda el tema de la utilización del lenguaje en el Messenger y sus posibles repercusiones en los manuscritos de los estudiantes de nivel medio superior. Es un estudio desarrollado entre adolescentes usuarios del Messenger, que utilizan la gama de símbolos y signos que les proporciona esta herramienta, para sustituir la escritura que comúnmente se usa en los manuscritos. La metodología es del enfoque cualitativo y se trata de un estudio comparativo basado en el modelo de comunicación referencial. El trabajo empírico se realizó entre un total de 16 jóvenes de dos escuelas diferentes de nivel medio superior, cuya edad está entre los 15 y 17 años, los cuales a su vez se integraron en dos grupos de ocho sujetos para el estudio en una primera etapa y otros ocho en una segunda. Básicamente se diferenciaron los que utilizan con mucha frecuencia el Messenger y los que lo utilizan muy poco, o no lo utilizan. Las técnicas de recolección de datos fueron: observación durante sesiones de chat, escritos a máquina (ordenador) y manuscritos. La técnica para la interpretación de los datos fue de análisis de contenido. Los resultados sugieren que existe escasa relación entre la utilización de signos y símbolos en el Messenger y la calidad en la redacción de los textos, particularmente en los manuscritos.
Digital tribes in the university classrooms
Authors: Gutiérrez-Martín Alfonso , Palacios-Picos Andrés , Torrego-Egido Luis 
Published: March 2010

The discourse stating that the profound changes in ICT of the last decade have also radically altered the way our students learn, and that they can all now be considered digital natives, is increasingly prevalent. However, this paper argues that these changes are not as immediate, automatic or beneficial as the dominant political and technological discourse on the benefits of ICT would have us believe, and that they give rise to many different situations that characterize university teaching and learning practice. Using the ratings of three Likert questionnaires on information processing and communication in three different environments (Moodle, Tuenti and the classroom itself), and applying multivariate techniques (factor analysis and cluster analysis), we have found four clusters: pro-ICT students, anti-ICT students, listless student and neutral student. The presence of such segments of students allows us to conclude that, although computers are nowadays taken for granted in Higher Education classrooms, we are perhaps overestimating both the real impact of ICT on teaching and students’ digital competencies, and that this false perception of reality benefits technology vendors but not methodological and pedagogic innovation, which can only be achieved through the necessary reflection on education matters from educational principles.
Se ha extendido el discurso que afirma que los profundos cambios en las TIC experimentados en la última década han modificado también radicalmente el aprendizaje de nuestros estudiantes universitarios, considerados todos ellos nativos digitales. En este artículo se sostiene, sin embargo, que dichos cambios no son tan inmediatos, automáticos o beneficiosos como el discurso dominante sobre la bondad de las TIC pretende hacernos creer, y que dan lugar a múltiples y variadas situaciones intermedias que caracterizan la actual enseñanza universitaria. Utilizando las valoraciones de tres cuestionarios tipo Likert sobre los procesos de información y comunicación en tres entornos diferenciados (una plataforma virtual de enseñanza aprendizaje, Moodle, Tuenti, como ejemplo de red social, y las aulas presenciales) y mediante técnicas multivariantes (análisis factorial y de conglomerados) se encuentran cuatro segmentos de estudiantes: alumnado optimista o pro-TIC, alumnado pesimista o anti-TIC, alumnado apático y alumnado neutral. La presencia de dichos segmentos de estudiantes nos permite concluir que, aunque la presencia del ordenador en las aulas universitarias forma ya parte del imaginario colectivo, tal vez se esté sobrevalorando tanto el impacto de las TIC en la educación superior como las competencias digitales de los alumnos, y que esta falsa percepción de la realidad puede beneficiar a los vendedores de tecnología, pero no a la innovación metodológica, que sólo se podrá conseguir mediante la necesaria reflexión desde postulados educativos.
I want to be a journalist: looking for motivation in journalism
Authors: Pastor-Alonso María-de-los-Ángeles 
Published: March 2010

This paper has an approach to the different characteristics which make up the public’s image of journalists, analysing the motivations behind the decision of those who became and those who want to become journalists. In the case of professional journalists, there is a theoretical framework from which to analyze the essential influences on the decision to become a journalist: we can underline the development of personal talents, and the social influence of journalism and its existential possibilities. These reasons help explain some professional behaviour and attitudes, and point to why journalism is a questionable profession in Spain nowadays. The ideal profile of a journalist inevitably influences the value placed on the work of journalists, and also affects the decision of those who contemplate a career in journalism. Moreover, these youngsters who want to become journalists – whose motivations are contrasted in an investigation into students in the final year of High School and the first year of university - accept the usual stereotypes of journalists, even those which present a kind of mythical image, but these youngsters are also conscious of the need for personal criticism. They call for the return to the most important values and qualities of journalism to develop professional competence.
Se realiza en este artículo un acercamiento a las características que configuran la imagen del periodista ante el gran público, examinando los motivos que intervienen en la decisión de quienes se han dedicado a este oficio y de quienes desean hacerlo en el futuro. En el caso de los profesionales en ejercicio, se dispone ya de un marco teórico suficiente para analizar las influencias que en su momento fueron determinantes en la vocación de los informadores: destacan el desarrollo de ciertos talentos personales, el papel social atribuido al periodismo y sus posibilidades vitales. Estas razones explican ciertos comportamientos y actitudes profesionales y señalan las causas de que en la actualidad el periodismo sea una profesión socialmente cuestionada en España. El «perfil ideal» del periodista actúa de rasero inevitable para valorar el trabajo de los comunicadores, e influye, a su vez, en la elección de quienes se inclinan por el periodismo como profesión. Por su parte, estos jóvenes que quieren ser periodistas –cuyas motivaciones son contrastadas a través de un sondeo realizado a estudiantes del último curso de Bachillerato y primero de la licenciatura– aceptan los estereotipos que circulan sobre los informadores, incluso los que proyectan una estampa más mitificada, pero también son conscientes de la necesidad de una seria autocrítica. Ellos mismos reivindican, en suma, la vuelta a los valores más apreciados del oficio y las cualidades que desarrollen la competencia profesional.
Cleavage of Transaldolase by Granzyme B Causes the Loss of Enzymatic Activity with Retention of Antigenicity for Multiple Sclerosis Patients
Authors: Niland Brian , Miklossy Gabriella , Banki Katalin , Biddison William E. , Casciola-Rosen Livia , Rosen Antony , Martinvalet Denis , Lieberman Judy , Perl Andras 
Published: March 2010

AbstractMultiple sclerosis (MS) is an autoimmune demyelinating disease of the CNS resulting from a progressive loss of oligodendrocytes. Transaldolase (TAL) is expressed at selectively high levels in oligodendrocytes of the brain, and postmortem sections show concurrent loss of myelin basic protein and TAL from sites of demyelination. Infiltrating CD8+ CTLs are thought to play a key role in oligodendrocyte cell death. Cleavage by granzyme B (GrB) is predictive for autoantigenicity of self-proteins, thereby further implicating CTL-induced death in the initiation and propagation of autoimmunity. The precursor frequency and CTL activity of HLA-A2–restricted TAL 168–176–specific CD8+ T cells is increased in MS patients. In this paper, we show that TAL, but not myelin basic protein, is specifically cleaved by human GrB. The recognition site of GrB that resulted in the cleavage of a dominant TAL fragment was mapped to a VVAD motif at aa residue 27 by N-terminal sequencing and confirmed by site-directed mutagenesis. The major C-terminal GrB cleavage product, residues 28–337, had no enzymatic activity but retained the antigenicity of full-length TAL, effectively stimulating the proliferation and CTL activity of PBMCs and of CD8+ T cell lines from patients with MS. Sera of MS patients exhibited similar binding affinity to wild-type and GrB-cleaved TAL. Because GrB mediates the killing of target cells and cleavage by GrB is predictive of autoantigen status of self proteins, GrB-cleaved TAL-specific T cell-mediated cytotoxicity may contribute to the progressive destruction of oligodendrocytes in patients with MS.
Proinflammatory Cytokine IL-1β Stimulates IL-8 Synthesis in Mast Cells via a Leukotriene B4 Receptor 2-Linked Pathway, Contributing to Angiogenesis
Authors: Kim Geun-Young , Lee Jin-Wook , Ryu Ho-Cheol , Wei Jun-Dong , Seong Chu-Myong , Kim Jae-Hong 
Published: March 2010

Abstract
Recent studies have suggested that mast cells have critical roles in angiogenesis. However, the detailed mechanism by which mast cells contribute to angiogenesis is not yet clearly understood, especially in response to proinflammatory cytokines. In this study, we showed that the proinflammatory cytokine IL-1β induces the synthesis of IL-8, a potent angiogenic factor, in human mast cells via the leukotriene B4 receptor (BLT)2. We also characterized the BLT2 downstream signaling pathway and determined that BLT2-mediated IL-8 synthesis involves the upregulation of Nox1, a member of the NADPH oxidase family, Nox1-dependent reactive oxygen species generation and the subsequent activation of the redox-sensitive transcription factor NF-κB. For instance, knockdown of BLT2 and Nox1 with specific small interfering RNA, treatment with a specific BLT2 antagonist, LY255283, or treatment with a potential Nox inhibitor, diphenylene iodonium, suppressed IL-1β–induced IL-8 synthesis. We found that the conditioned media collected from IL-1β–treated human mast cell line HMC-1 had significantly enhanced angiogenic activity that could be dramatically attenuated by either small interfering RNA knockdown of BLT2 or treatment with neutralizing Ab to IL-8. Finally, the experiments were repeated using human primary cord blood-derived mast cells, and the results were clearly reproduced. Taken together, our results suggest that BLT2-Nox1-reactive oxygen species–dependent pathway plays a role in promoting the secretion of IL-8 from human mast cells in response to the proinflammatory cytokine IL-1β, thus contributing to angiogenesis.
Hypoxia-Mediated Expression of 5-Lipoxygenase–Activating Protein Involves HIF-1α and NF-κB and MicroRNAs 135a and 199a-5p
Authors: Gonsalves Caryn S. , Kalra Vijay K. 
Published: March 2010

Abstract
Hypoxia occurs in a number of pathological states, such as pulmonary, hematological, and cardiovascular disorders. In this study, we examined the molecular mechanism by which hypoxia contributes to increased leukotriene formation. Our studies showed hypoxia augmented the expression of 5-lipoxygenase activating protein (FLAP), a key enzyme in leukotriene formation, in both human pulmonary microvascular endothelial cells and a transformed human brain endothelial cell line. Hypoxia-induced FLAP mRNA expression involved activation of NADPH-oxidase, PI-3 kinase, mitogen-activated protein kinase, NF-κB, and hypoxia-inducible factor (HIF)-1α. Hypoxia-induced FLAP promoter activity was attenuated on mutation of hypoxia-response elements (HREs) and NF-κB binding motif in the FLAP promoter. Hypoxia also augmented binding of HIF-1α to HREs in FLAP promoter as demonstrated by EMSA with nuclear extracts. Furthermore, chromain immunoprecipitation analysis showed HIF-1α bound to HREs in native chromatin obtained from hypoxia-treated cells. Next, we examined the role of HIF-1α regulated microRNAs on FLAP expression. Our studies showed decreased expression of miR-135a and miR-199a-5p in response to hypoxia. However, overexpression of anti–miR-135a and anti–miR-199a-5p oligonucleotides led to a several fold increased FLAP mRNA and protein expression. These studies demonstrate for the first time that hypoxia-mediated FLAP expression is regulated by HREs and NF-κB site in its promoter, and negatively regulated by miR-135a and miR-199a-5p, which target the 3′-UTR of FLAP mRNA. An understanding of these regulatory pathways provides new avenues to ameliorate leukotriene formation and hence reactive airway disease, and inflammation in individuals who have sickle cell disease.
B Cells Are Required for Optimal CD4+ and CD8+ T Cell Tumor Immunity: Therapeutic B Cell Depletion Enhances B16 Melanoma Growth in Mice
Authors: DiLillo David J. , Yanaba Koichi , Tedder Thomas F. 
Published: March 2010

Abstract
B lymphocytes can both positively and negatively regulate cellular immune responses. Previous studies have demonstrated augmented T cell-mediated tumor immunity in genetically B cell-deficient mice, suggesting that therapeutic B cell depletion would enhance tumor immunity. To test this hypothesis and quantify B cell contributions to T cell-mediated anti-tumor immune responses, mature B cells were depleted from wild-type adult mice using CD20 mAb prior to syngeneic B16 melanoma tumor transfers. Remarkably, s.c. tumor volume and lung metastasis were increased 2-fold in B cell-depleted mice. Effector-memory and IFN-γ–or TNF-α–secreting CD4+ and CD8+ T cell induction was significantly impaired in B cell-depleted mice with tumors. Tumor Ag-specific CD8+ T cell proliferation was also impaired in tumor-bearing mice that lacked B cells. Thus, B cells were required for optimal T cell activation and cellular immunity in this in vivo nonlymphoid tumor model. Although B cells may not have direct effector roles in tumor immunity, impaired T cell activation, and enhanced tumor growth in the absence of B cells argue against previous proposals to augment tumor immunity through B cell depletion. Rather, targeting tumor Ags to B cells in addition to dendritic cells is likely to optimize tumor-directed vaccines and immunotherapies.
Neutrophil Transmigration Mediated by the Neutrophil-Specific Antigen CD177 Is Influenced by the Endothelial S536N Dimorphism of Platelet Endothelial Cell Adhesion Molecule-1
Authors: Bayat Behnaz , Werth Silke , Sachs Ulrich J. H. , Newman Debra K. , Newman Peter J. , Santoso Sentot 
Published: March 2010

Abstract
The human neutrophil-specific adhesion molecule CD177 (also known as the NB1 alloantigen) becomes upregulated on the cell surface in a number of inflammatory settings. We recently showed that CD177 functions as a novel heterophilic counterreceptor for the endothelial junctional protein PECAM-1 (CD31), an interaction that is mediated by membrane-proximal PECAM-1 IgD 6, which is known to harbor an S536N single nucleotide polymorphism of two major isoforms V98N536G643 and L98S536R643 and a yet-to-be-determined region on CD177. In vitro transendothelial migration experiments revealed that CD177+ neutrophils migrated significantly faster through HUVECs expressing the LSR, compared with the VNG, allelic variant of PECAM-1 and that this correlated with the decreased ability of anti-PECAM-1 Ab of ITIM tyrosine phosphorylation in HUVECs expressing the LSR allelic variant relative to the VNG allelic variant. Moreover, engagement of PECAM-1 with rCD177-Fc (to mimic heterophilic CD177 binding) suppressed Ab-induced tyrosine phosphorylation to a greater extent in cells expressing the LSR isoform compared with the VNG isoform, with a corresponding increased higher level of β-catenin phosphorylation. These data suggest that heterophilic PECAM-1/CD177 interactions affect the phosphorylation state of PECAM-1 and endothelial cell junctional integrity in such a way as to facilitate neutrophil transmigration in a previously unrecognized allele-specific manner.