bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health Care Transition in Patients With Type 1 Diabetes
Authors: Garvey Katharine C. , Wolpert Howard A. , Rhodes Erinn T. , Laffel Lori M. , Kleinman Ken , Beste Margaret G. , Wolfsdorf Joseph I. , Finkelstein Jonathan A. 
Published: June 2012

OBJECTIVE
To examine characteristics of the transition from pediatric to adult care in emerging adults with type 1 diabetes and evaluate associations between transition characteristics and glycemic control.

RESEARCH DESIGN AND METHODS
We developed and mailed a survey to evaluate the transition process in emerging adults with type 1 diabetes, aged 22 to 30 years, receiving adult diabetes care at a single center. Current A1C data were obtained from the medical record.

RESULTS
The response rate was 53% (258 of 484 eligible). The mean transition age was 19.5 ± 2.9 years, and 34% reported a gap &gt;6 months in establishing adult care. Common reasons for transition included feeling too old (44%), pediatric provider suggestion (41%), and college (33%). Less than half received an adult provider recommendation and &lt;15% reported having a transition preparation visit or receiving written transition materials. The most recent A1C was 8.1 ± 1.3%. Respondents who felt mostly/completely prepared for transition had lower likelihood of a gap &gt;6 months between pediatric and adult care (adjusted odds ratio 0.47 [95% CI 0.25–0.88]). In multivariate analysis, pretransition A1C (β = 0.49, P &lt; 0.0001), current age (β = −0.07, P = 0.03), and education (β = −0.55, P = 0.01) significantly influenced current posttransition A1C. There was no independent association of transition preparation with posttransition A1C (β = −0.17, P = 0.28).

CONCLUSIONS
Contemporary transition practices may help prevent gaps between pediatric and adult care but do not appear to promote improvements in A1C. More robust preparation strategies and handoffs between pediatric and adult care should be evaluated.
Performance of HbA1c as an Early Diagnostic Indicator of Type 1 Diabetes in Children and Youth
Authors: Vehik Kendra , Cuthbertson David , Boulware David , Beam Craig A. , Rodriguez Henry , Legault Laurent , Hyytinen Mila , Rewers Marian J. , Schatz Desmond A. , Krischer Jeffrey P. ,   the TEDDY, TRIGR, Diabetes Prevention Trial–Type 1, and Type 1 Diabetes TrialNet Natural History Study Groups
Published: June 2012

OBJECTIVE
The aim of this study was to evaluate HbA1c as an alternative criterion for impaired glucose tolerance (IGT) or type 1 diabetes (T1D) in high-risk subjects &lt;21 years of age.

RESEARCH DESIGN AND METHODS
Subjects &lt;21 years of age who participated in the prospective DPT-1, TEDDY, TRIGR, and Type 1 Diabetes TrialNet Natural History (TrialNet) studies and had an HbA1c within 90 days of an OGTT with a 2-h plasma glucose (2-hPG) measure were included. An OGTT of 140–199 mg/dL defined IGT, and an OGTT with 2-hPG ≥200 mg/dL or fasting plasma glucose ≥126 mg/dL defined diabetes. HbA1c ≥5.7% defined IGT, and HbA1c ≥ 6.5% defined diabetes. Receiver-operating characteristic curve analysis was used to assess diagnostic accuracy of HbA1c compared with OGTT.

RESULTS
There were 587 subjects from DPT-1, 884 from TrialNet, 91 from TEDDY, and 420 from TRIGR. As an indicator for IGT, HbA1c sensitivity was very low across the studies (8–42%), and specificity was variable (64–95%). With HbA1c ≥6.5% threshold used for T1D diagnosis, the sensitivity was very low and specificity was high (sensitivity and specificity: DPT-1 24 and 98%, TrialNet 28 and 99%, TEDDY 34 and 98%, and TRIGR 33 and 99%, respectively). The positive predictive value of HbA1c ≥6.5% for the development of T1D was variable (50–94%) across the four studies.

CONCLUSIONS
HbA1c ≥6.5% is a specific but not sensitive early indicator for T1D in high-risk subjects &lt;21 years of age diagnosed by OGTT or asymptomatic hyperglycemia. Redefining the HbA1c threshold is recommended if used as an alternative criterion in diagnosing T1D.
Formulation and evaluation of Norfloxacin gastro retentive drug delivery systems using natural polymers
Authors: Thahera P D , Ashok Mr , Latha K , Shailaja T , Nyamathulla S , Uhumwangho M U 
Published: June 2012

Gastric retentive floating drug delivery system (GFDDS) is enabled the prolonged continuous input of the drug to the upper parts of the gastrointestinal (GI) tract and improves the bioavailability of medications with narrow absorption window. The design of the delivery system is based on the controlled release formulation with floating and swelling features in order to prolong the gastric retention time of the drug delivery systems. In the present study norfloxacin as candidate, guar gum, sodium CMC, HPMC15 KM is studied along with other excipients like PVP K30 (binder), sodium bicarbonate microcrystalline cellulose were used in different concentrations to get the desired controlled release profile over a period of 12 hrs. All the formulations were evaluated for buoyancy lag time, duration of buoyancy, dimensional stability, drug content and in vitro drug release profile. Based on the in vitro studies carried out for the optimized formulation by dissolution the performance of the developed formulation promises to be efficient in controlling the drug release rate with the guar gum, a natural polymer.DOI: http://dx.doi.org/10.3329/icpj.v1i7.10809International Current Pharmaceutical Journal 2012, 1(7): 155-164
Implementation of cervical cancer screening using visual inspection with acetic acid in rural Mozambique: successes and challenges using HIV care and treatment programme investments in Zambézia Province
Authors: Moon Troy D , Silva‐Matos Carla , Cordoso Aventina , Baptista Alberto J , Sidat Mohsin , Vermund Sten H 
Published: June 2012

BackgroundIn order to maximize the benefits of HIV care and treatment investments in sub‐Saharan Africa, programs can broaden to target other diseases amenable to screening and efficient management. We nested cervical cancer screening into family planning clinics at select sites also receiving PEPFAR support for antiretroviral therapy (ART) rollout. This was done using visual inspection with acetic acid (VIA) by maternal child health nurses. We report on achievements and obstacles in the first year of the program in rural Mozambique.MethodsVIA was taught to clinic nurses and hospital physicians, with a regular clinical feedback loop for quality evaluation and retraining. Cryotherapy using carbon dioxide as the refrigerant was provided at clinics; loop electrosurgical excision procedure (LEEP) and surgery were provided at the provincial hospital for serious cases. No pathology services were available.ResultsNurses screened 4651 women using VIA in Zambézia Province in year one of the program, more than double the Ministry of Health service target. VIA was judged positive for squamous intraepithelial lesions in 8% (n=380) of the women (9% if age ≥30 years (n=3154) and 7% if age <30 years (n=1497); p=0.02). Of the 380 VIA‐positive women, 4% (n=16) had lesions (0.3% of 4651 total screened) requiring referral to Quelimane Provincial Hospital. Fourteen (88%) of these 16 women were seen at the hospital, but records were inadequate to judge outcomes. Of women screened, 2714 (58%) either had knowledge of their HIV status prior to VIA or were subsequently sent for HIV testing, of which 583 (21%) were HIV positive.ConclusionsScreening and clinical services were successfully provided on a large scale for the first time ever in these rural clinics. However, health manpower shortages, equipment problems, poor paper record systems and a limited ability to follow‐up patients inhibited the quality of the cervical cancer screening services. Using prior HIV investments, chronic disease screening and management for cervical cancer is feasible even in severely resource‐constrained rural Africa.
Two‐Dimensional Assembly of Symmetric Colloidal Dimers under Electric Fields
Authors: Ma Fuduo , Wang Sijia , Smith Lois , Wu Ning 
Published: June 2012

AbstractLike atoms and molecules with directional interactions, anisotropic particles could potentially assemble into a much wider range of crystalline arrays and meso‐structures than spherical particles with isotropic interactions. In this paper, the electric‐field directed assembly of geometrically anisotropic particles–colloidal dimers is studied. Rich phase behavior and different assembly regimes are found, primarily arising from the broken radial symmetry in particles. The orientations of individual dimers depend on the frequency of the electric field, the ramping direction of frequency, and the salt concentration. The competition and balance between the hydrodynamic, electric, and Brownian torques determine the orientation of individual particles, while the competition between the electrohydrodynamic force and dipolar interaction determines the aggregation of aligned particles at a given experimental condition. The field distribution near the electrode is critical to understand the orientation and assembly behavior of colloidal dimers on a conducting substrate. This study also demonstrates the effectiveness, the reversibility, and potential opportunity of applying electric field to control the orientation and direct the assembly of non‐spherical particles. In particular, two dimensional close‐packed crystals of perpendicularly aligned dimers are obtained, which shows promise in fabricating 3D photonic crystals based on dimer‐like colloids and field‐directed display.
Palladium‐Catalyzed CH Oxidation of Isoquinoline N‐Oxides: Selective Alkylation with Dialkyl Sulfoxides and Halogenation with Dihalo sulfoxides
Authors: Yao Bo , Song Ren‐Jie , Liu Yan , Xie Ye‐Xiang , Li Jin‐Heng , Wang Meng‐Ke , Tang Ri‐Yuan , Zhang Xing‐Guo , Deng Chen‐Liang 
Published: June 2012

AbstractA novel palladium‐catalyzed CH oxidation of isoquinoline N‐oxides has been developed for regioselectively synthesizing substituted isoquinolines. The method represents the first example of using dialkyl sulfoxides as the alkyl sources for the construction of 1‐alkylated isoquinolines. Moreover, the regioselective halogenation of isoquinoline N‐oxides is also successful using dihalo sulfoxides as the halide sources.
The clinical spectrum of Castleman's disease
Authors: Dispenzieri Angela , Armitage James O. , Loe Matt J. , Geyer Susan M. , Allred Jake , Camoriano John K. , Menke David M. , Weisenburger Dennis D. , Ristow Kay , Dogan Ahmet , Habermann Thomas M. 
Published: June 2012

AbstractCastleman's disease (CD) is a rare, poorly understood lymphoproliferative disease. The spectrum of symptoms and course of disease are broad, but there is no large study describing the natural history of this disease. Basic clinic and laboratory data from the records of 113 patients with CD evaluated at the Mayo Clinic and University of Nebraska were abstracted. The impact of these variables on overall survival (OS) from time of diagnosis was evaluated. Sixty patients had multicentric disease. Of the patients with multicentric CD, 32% had criteria sufficient for a diagnosis of POEMS syndrome. For all patients, 2, 5, and 10‐year OS was 92%, 76%, 59%, respectively. Most of the factors identified as risk factors for death on univariate analysis cosegregated with diagnostic criteria for POEMS syndrome, which supported the concept of four categories of CD, which are (along with their 5‐year OS): (1) unicentric CD (91%); (2) multicentric CD associated with the osteosclerotic variant of POEMS syndrome (90%); (3); multicentric CD without POEMS syndrome (65%); and (4) multicentric CD with POEMS syndrome without osteosclerotic lesions (27%). We have demonstrated that CD represents a spectrum of disease that can be differentiated by simple prognostic factors that provide a framework for further study. Am. J. Hematol. 2012. © 2012 Wiley Periodicals, Inc.
The impact of regulatory enforcement and consultation visits on workers' compensation claims incidence rates and costs, 1999–2008
Authors: Foley Michael , Fan Z. Joyce , Rauser Eddy , Silverstein Barbara 
Published: June 2012

AbstractBackgroundStudies of regulatory effectiveness have shown mixed evidence of impact of inspections on injury rates. We examine changes in workers compensation claims rates and costs for Washington employers having either an inspection, with or without citation, or a voluntary consultation activity.MethodWe merge 10 years of enforcement and consultation activity with workers compensation records at the individual workplace level for stable firms with a single business location and at least 10 full‐time employees. The change in claims incidence rates (CIRs) was estimated, controlling for workplace claims rate history, size, and industry. Separate analyses were performed for non‐musculoskeletal and musculoskeletal (MSD) CIRs, claims costs and for enforcement activities with citation and without citation.ResultsEnforcement activities are associated with a significant reduction in CIRs and costs. Similar results may also be attributable to consultations. Inspections were associated with a 4% decline in time‐loss claims rates relative to uninspected workplaces. The effect strengthens when MSD claims are excluded. Citations for non‐compliance are associated with a 20% decline in non‐MSD CIRs relative to uninspected workplaces. There is also some evidence for a reduction in MSD claims rates beginning in the second year following inspection. Enforcement and consultation activity is associated with substantial decreases in claims costs.ConclusionsEnforcement activities make a significant contribution to reducing CIRs and costs. Similar results following consultations may also exist. Inspections with citations are more effective than those without. Claims rates for non‐MSD injuries, related to hazards covered by specific standards, are more affected in the year following the visit, while those for MSDs take longer to begin falling. Am. J. Ind. Med. 55:976–990, 2012. © 2012 Wiley Periodicals, Inc.
The Upper Midwest Health Study: Industry and occupation of glioma cases and controls
Authors: Ruder Avima M. , Waters Martha A. , Carreón Tania , Butler Mary A. , Calvert Geoffrey M. , Davis‐King Karen E. , Waters Kathleen M. , Schulte Paul A. , Mandel Jack S. , Morton Roscoe F. , Reding Douglas J. , Rosenman Kenneth D. ,   and the Brain Cancer Collaborative Study Group
Published: June 2012

AbstractBackgroundUnderstanding glioma etiology requires determining which environmental factors are associated with glioma. Upper Midwest Health Study case–control participant work histories collected 1995–1998 were evaluated for occupational associations with glioma. “Exposures of interest” from our study protocol comprise our a priori hypotheses.Materials and MethodsYear‐long or longer jobs for 1,973 participants were assigned Standard Occupational Classifications (SOC) and Standard Industrial Classifications (SIC). The analysis file includes 8,078 SIC‐ and SOC‐coded jobs. For each individual, SAS 9.2 programs collated employment with identical SIC‐SOC coding. Distributions of longest “total employment duration” (total years worked in jobs with identical industry and occupation codes, including multiple jobs, and non‐consecutive jobs) were compared between cases and controls, using an industrial hygiene algorithm to group occupations.ResultsLongest employment duration was calculated for 780 cases and 1,156 controls. More case than control longest total employment duration was in the “engineer, architect” occupational group [16 cases, 10 controls, odds ratio (OR) 2.50, adjusted for age group, sex, age and education, 95% confidence interval (CI) 1.12–5.60]. Employment as a food processing worker [mostly butchers and meat cutters] was of borderline significance (27 cases, 21 controls, adjusted OR: 1.78, CI: 0.99–3.18).ConclusionsAmong our exposures of interest work as engineers or as butchers and meat cutters was associated with increased glioma risk. Significant associations could be due to chance, because of multiple comparisons, but similar findings have been reported for other glioma studies. Our results suggest some possible associations but by themselves could not provide conclusive evidence. Am. J. Ind. Med. 55:747–755, 2012. © 2012 Wiley Periodicals, Inc.
Chronological and Morphological Study of Heart Development in the Rat
Authors: Marcela Salazar García , Cristina Revilla Monsalve María , Angel Palomino Garibay Miguel , Manuel Arteaga Martínez , Sofía Díaz‐Cintra , Patricia De La Rosa‐Santander , Bladimir Roque‐Ramírez , Concepción Sánchez Gómez 
Published: June 2012

AbstractAdult and embryonic laboratory rats have been used as a mammalian model organism in biomedical research, descriptive and experimental cardiac embryology, and experimental teratology. There have been, however, considerable variations and discrepancies concerning the developmental staging of the rat embryo in the reported literature, which have resulted in several controversies and inconsistencies. Therefore, we carried out a careful anatomical and histological study of rat cardiac morphogenesis from the premorphogenetic period to the mature heart in a newborn pup. A correlation between the chronology and morphological features of the heart and embryo or newborn was made. We provide a simple and comprehensive guide relating the developmental timing and fate of the embryonic components of the heart and their morphological changes in the rat based on in vivo labeling studies in the chick. We also compare the timing of heart development in rats, humans, and mice. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc.
A chelate complex‐enhanced luminol system for selective determination of Co(II), Fe(II) and Cr(III)
Authors: Kim Kyung Min , Kim Young Ho , Oh Sang‐Hyub , Lee Sang Hak 
Published: June 2012

ABSTRACTA determination method for Co(II), Fe(II) and Cr(III) ions by luminol‐H2O2 system using chelating reagents is presented. A metal ion‐chelating ligand complex with a Co(II) ion and a chelating reagent like ethylenediaminetetraacetic acid (EDTA) produced highly enhanced chemiluminescence (CL) intensity as well as longer lifetime in the luminol‐H2O2 system compared to metals that exist as free ions. Whereas free Cu(II) and Pb(II) ions had a strong catalytic effect on the luminol‐H2O2 system, significantly, the complexes of Cu(II) and Pb(II) with chelating reagents lost their catalytic activity due to the chelating reagents acting as masking agents. Based on the observed phenomenon, it was possible to determine Co(II), Fe(II) and Cr(III) ions with enhanced sensitivity and selectivity using the chelating reagents of the luminol‐H2O2 system. The effects of ligand, H2O2 concentration, pH, buffer solution and concentrations of chelating reagents on CL intensity of the luminol‐H2O2 system were investigated and optimized for the determination of Co(II), Fe(II) and Cr(III) ions. Under optimized conditions, the calibration curve of metal ions was linear over the range of 2.0 × 10‐8 to 2.0 × 10‐5 M for Co(II), 1.0 × 10‐7 to 2.0 × 10‐5 M for Fe (II) and 2.0 × 10‐7 to 1.0 × 10‐4 M for Cr(III). Limits of detection (3σ/s) were 1.2 × 10‐8, 4.0 × 10‐8 and 1.2 × 10‐7 M for Co(II), Fe(II) and Cr(III), respectively. Copyright © 2012 John Wiley & Sons, Ltd.
Development and validation of an enantioselective LC‐MS/MS method to quantify enantiomers of (±)‐TAK‐700 in rat plasma: lack of in vivo inversion of (+)‐TAK‐700 (Orteronel) to its antipode
Authors: Gurav Sandip , Police Anitha , Zainuddin Mohd , Punde Ravindra Ramachandra , Dewang Purushottam , V Chandregowda , Kethiri Raghava Reddy , Rajagopal Sriram , Mullangi Ramesh 
Published: June 2012

ABSTRACTA highly sensitive, specific and enantioselective assay has been developed and validated for the estimation of TAK‐700 enantiomers [(+)‐TAK‐700 and (−)‐TAK‐700] in rat plasma on LC‐MS/MS‐ESI in the positive‐ion mode. Liquid–liquid extraction was used to extract (±)‐TAK‐700 enantiomers and IS (phenacetin) from rat plasma. TAK‐700 enantiomers were separated using methanol and 5 mm ammonium acetate (80:20, v/v) at a flow rate of 0.7 mL/min on a Chiralcel OJ‐RH column. The total run time was 7.0 min and the elution of (+)‐TAK‐700, (−)‐TAK‐700 and IS occurred at 3.71, 4.45 and 4.33 min, respectively. The MS/MS ion transitions monitored were m/z 308.2 → 95.0 for TAK‐700 and m/z 180.2 → 110.1 for IS. The standard curves for TAK‐700 enantiomers were linear (r2 > 0.998) in the concentration range 2.01–2015 ng/mL for each enantiomer. The inter‐ and intra‐day precisions were in the ranges 3.74–7.61 and 2.06–8.71% and 3.59–9.00 and 2.32–11.0% for (+)‐TAK‐700 and (−)‐TAK‐700, respectively. Both the enantiomers were found to be stable in a battery of stability studies. This novel method was applied to the study of stereoselective oral pharmacokinetics of (+)‐TAK‐700 and it was unequivocally demonstrated that (+)‐TAK‐700 does not undergo chiral inversion to its antipode in vivo. Copyright © 2012 John Wiley & Sons, Ltd.
The London Pathways Project: Evaluating the effectiveness of a consultation model for personality disordered offenders
Authors: Minoudis Philip , Shaw Jake , Craissati Jackie 
Published: June 2012

ABSTRACTBackgroundA recent government strategy has been developed to meet the challenges posed by personality disordered offenders. A ‘pathways project’ was piloted in four London boroughs to assess the implementation of some elements of the strategy.AimsThis paper focuses on the scope and the effectiveness of 2 years of the project.MethodProbation caseloads were screened for personality disorder. Risk information and pathways were monitored and recorded over 2 years. Psychologists provided consultation, training and direct co‐working as interventions.ResultsThe findings include a description of the samples identified, the range of project activity, pathway outcomes and factors associated with or predictive of successes and failures.ConclusionsThe findings supported the implementation of the pathways model to fulfil aspects of the offender personality disorder strategy, such as facilitating entry into treatment and interventions and to a lesser extent planning safer return to the community. The consultation model, including low‐intensity direct contact with project psychologists, improved outcomes for personality disordered offenders.ImplicationsObservations from experiences of the 2‐year pilot and ideas to assist with a wider implementation of the strategy are provided. Copyright © 2012 John Wiley & Sons, Ltd.
A joint offender personality disorder pathway strategy: An outline summary
Authors: Joseph Nick , Benefield Nick 
Published: June 2012

ABSTRACTBackground and purposeIn 1999, the Home Office published a public consultation on the need for better management of offenders with severe personality disorders. The Dangerous and Severe Personality Disorder (DSPD) Programme was launched in 2001. Following a stocktake of the DSPD Programme in 2008, the Department of Health and the National Offender Management Service (NOMS) started the next phase of strategic development for the management of offenders with personality disorder. This paper presents the key features of the Coalition Government's strategy for offenders with personality disorders.ConclusionThis strategy offers a co‐ordinated joint approach by both the National Health Service and the NOMS to the co‐commissioning and development of pathway services. Copyright © 2012 John Wiley & Sons, Ltd.