bluuebunny/crossref_metadata_2025_split huggingface dataset:
IL-33 Priming Regulates Multiple Steps of the Neutrophil-Mediated Anti-Candida albicans Response by Modulating TLR and Dectin-1 Signals
Authors: Le Hongnga T. , Tran Vuvi G. , Kim Wonyoung , Kim Juyang , Cho Hong R. , Kwon Byungsuk 
Published: June 2012

Abstract
IL-33 is known to play an important role in Th2 immunity. In this study, we investigated the effect of IL-33 pretreatment on anti-fungal response using an acute Candida albicans peritoneal infection model. IL-33 pretreatment induced a rapid fungal clearance and markedly reduced the C. albicans infection-associated mortality. The priming effect of IL-33 occurred during multiple steps of the neutrophil-mediated anti-fungal response. First, the anti-fungal effect occurred due to the rapid and massive recruitment of neutrophils to the site of infection as a result of the release of CXCR2 chemokines by peritoneal macrophages and by reversal of the TLR-induced reduction of CXCR2 expression in neutrophils during IL-33 priming. Second, conditioning of neutrophils by IL-33 activated the TLR and dectin-1 signaling pathways, leading to the upregulation of complement receptor 3 expression induced by C. albicans. Upregulated CR3 in turn increased the phagocytosis of opsonized C. albicans and resulted in the production of high levels of reactive oxygen species and the subsequent enhanced killing activity of neutrophils. Taken together, our results suggest that IL-33 can regulate the anti-fungal activity of neutrophils by collaborative modulation of the signaling pathways of different classes of innate immune receptors.
Ce qu’accompagner veut dire
Authors: Gagnon Éric , Moulin Pierre , Eysermann Béatrice 
Published: June 2012

Le mot « accompagnement » s’est largement diffusé et popularisé au cours dernières années pour qualifier des pratiques d’intervention auprès de publics variés, dans des secteurs les plus divers — malades, sans-abri, élèves en difficultés, immigrants, etc.. À partir d’entrevues réalisées en France auprès d’intervenants oeuvrant dans quatre secteurs — soins palliatifs, soins aux personnes âgées, éducation, insertion au travail —, nous avons cherché à savoir ce que le mot accompagnement désigne et à dégager ce que ces pratiques ont en commun et ce qui les distingue. Nous avons ainsi mis en évidence le socle idéologique commun à des pratiques d’accompagnement par ailleurs très différentes. Cela nous a également permis de clarifier quelques-uns des enjeux posés par les transformations actuelles de l’intervention psychosociale.
A novel EPID‐based MLC QA method with log files achieving submillimeter accuracy
Authors: Liu Chenlu , Wang Binbing , Bai Xue , Cheng Xiaolong , Wang Xiaotong , Yang Xiaohua , Shan Guoping 
Published: June 2024

AbstractThe purpose of this study is to develop an electronic portal imaging device‐based multi‐leaf collimator calibration procedure using log files.Picket fence fields with 2–14 mm nominal strip widths were performed and normalized by open field. Normalized pixel intensity profiles along the direction of leaf motion for each leaf pair were taken. Three independent algorithms and an integration method derived from them were developed according to the valley value, valley area, full‐width half‐maximum (FWHM) of the profile, and the abutment width of the leaf pairs obtained from the log files. Three data processing schemes (Scheme A, Scheme B, and Scheme C) were performed based on different data processing methods. To test the usefulness and robustness of the algorithm, the known leaf position errors along the direction of perpendicular leaf motion via the treatment planning system were introduced in the picket fence field with nominal 5, 8, and 11 mm. Algorithm tests were performed every 2 weeks over 4 months.According to the log files, about 17.628% and 1.060% of the leaves had position errors beyond ± 0.1 and ± 0.2 mm, respectively. The absolute position errors of the algorithm tests for different data schemes were 0.062 ± 0.067 (Scheme A), 0.041 ± 0.045 (Scheme B), and 0.037 ± 0.043 (Scheme C). The absolute position errors of the algorithms developed by Scheme C were 0.054 ± 0.063 (valley depth method), 0.040 ± 0.038 (valley area method), 0.031 ± 0.031 (FWHM method), and 0.021 ± 0.024 (integrated method). For the efficiency and robustness test of the algorithm, the absolute position errors of the integration method of Scheme C were 0.020 ± 0.024 (5 mm), 0.024 ± 0.026 (8 mm), and 0.018 ± 0.024 (11 mm).Different data processing schemes could affect the accuracy of the developed algorithms. The integration method could integrate the benefits of each algorithm, which improved the level of robustness and accuracy of the algorithm. The integration method can perform multi‐leaf collimator (MLC) quality assurance with an accuracy of 0.1 mm. This method is simple, effective, robust, quantitative, and can detect a wide range of MLC leaf position errors.
High‐Efficiency and Stable Perovskite Solar Cells via Buried Interface Modification with Multi‐Functional Phosphorylcholine Chloride
Authors: Yuan Yin , Cao Yang , Yang Zhou , (Frank) Liu Shengzhong , Feng Jiangshan 
Published: June 2024

AbstractThe electron transport layer (ETL), perovskite layer, hole transport layer, and electrode layer collectively constitute the perovskite solar cells (PSCs). Each of these layers plays a critical role in the performance of devices. However, there are mismatches in crystal structure and energy levels between ETL materials and the perovskite layer, resulting in numerous defects at their interface. In this study, multifunctional organic molecule called phosphorylcholine chloride is designed to modify the interface between SnO2 and perovskite layer. This modification serves to both reduce oxygen vacancy defects in the SnO2 and passivate defects in the perovskite layer. Consequently, the conductivity and electron mobility of SnO2 are improved, and the higher‐quality of perovskite film is obtained. Ultimately, the optimized PSC device achieves an impressive champion power conversion efficiency (PCE) of 24.34% with minimal hysteresis index. Even after 1200 h of ambient exposure at 25 °C and 25% relative humidity without encapsulation, the device maintains an impressive 91.44% of its initial efficiency. Additionally, a PCE of 22.38% is attained in flexible PSCs. This research will pave the way for the development of low interface defects, high stability as well as high PCE perovskite solar cells.
Transcranial NIR Neuromodulation via Multifunctional Nano‐Optical Electrodes for Relieving Depressive Symptoms
Authors: Nie Jianfang , Zhang Ya , Wang Bingfang , Wu Haofan , Chang Zhiqiang , Ren Qinjuan , Zheng Jialin Charles , Zhao Dongyuan , Fang Yin 
Published: June 2024

AbstractNeuromodulation stands as a cornerstone in the therapeutic landscape for neurological disorders, yet the quest for selective stimulation of specific brain regions with minimal invasiveness and high spatiotemporal precision remains a formidable challenge. In this study, a multifunctional nano‐optical electrode (NOE) to mitigate depressive symptoms in animal models of depression is introduced. The NOEs' core–shell architecture integrates mesoporous carbon shells for optimal absorption of near‐infrared (NIR) light, alongside superparamagnetic ferric oxide nanocluster cores for magnetic resonance imaging (MRI) visibility. This configuration enables the precise excitation of untransfected neurons using NIR irradiation. The MRI‐guided NIR neuromodulation via NOEs can significantly alleviate depressive symptoms in mice. This is evidenced by the observed enhancement in pleasure‐seeking behaviors, improved motor functions, and a decrease in behaviors indicative of despair. The alleviation of depressive symptoms is ascribed to the NOEs' role as an efficient NIR light transducer, which boosts neuronal activity in the medial prefrontal cortex (mPFC). The MRI compatibility of the NOEs augments the spatial resolution, further refining the precision of neuromodulation. The multimodal, precise, transcranial, and non‐genetic approach of the NOEs‐based neuromodulation strategy heralds a new era in the optical‐theranostics of neurological disorders.
Strain‐Insensitive Pre‐Stretch‐Stabilized Polymer/Gold Hybrid Electrodes for Electrochemiluminescent Devices
Authors: Chen Ziyu , Zhou Runhui , Huang Jiaoya , Xu Huichen , Li Zemin , Wang Yushu , Bao Rongrong , He Jiang , Pan Caofeng 
Published: June 2024

AbstractThe quest for stretchable properties is at the forefront of research dedicated to on‐skin light–emitting devices. Inspired by the natural wonders of bioluminescence, electrochemiluminescent devices (ECLDs) are distinguished by straightforward design and reduced operating voltage, marking a departure from traditional current‐driven electroluminescent devices (ACELDs). The primary challenge of fully‐stretchable ECLDs lies in crafting electrodes that simultaneously satisfy the demands for conductivity, transparency, stretchability, oxidation resistance, and interface stability. This research introduces a groundbreaking wrinkled polymer‐gold composite electrode. It extends to 50% stretchability, offers outstanding conductivity at 10 Ω sq−1, achieves transparency above 60%, and withstands over 10 000 stretching cycles. Employing this material, alongside stretchable electrospinning fiber luminescent layers, enabled the creation of fully‐stretchable ECLDs. These devices not only shine brightly at 30 Cd m−2 but also retain more than 90% of luminosity when stretched up to 50%. Furthermore, this work has engineered stretchable devices featuring singular patterns and multi‐dot arrays. They exhibit consistent luminescent output under bending, twisting, and stretching when applied to skin. These findings not only highlight the potential of polymer‐gold composite electrodes in overcoming challenges faced by stretchable electronic devices but also provide new ideas for wearable technology that seamlessly integrates with human body.
An Ice‐Dissolving‐Crosslinking Method for Efficient and Large‐Scale Preparation of Polyelectrolyte Monoliths with Ultra‐Stability in Aqueous Environments
Authors: Ni Yunxia , Hu Rongjun , Cheng Ziyao , Meng Fandong , Sun Fuqian 
Published: June 2024

AbstractIce‐templating is a versatile method for constructing macro‐porous hydrophilic polymer materials. However, the ice‐templating method is generally limited by high energy cost and low efficiency for large‐scale fabrication. Further, due to its hydrophilic nature, the constructed materials are vulnerable to water swelling and have poor structural stability. Here, an Ice‐Dissolving‐Crosslinking (IDCr) method is developed for efficient and large‐scale preparation of polyelectrolyte monoliths with ultra‐stability in aqueous environment. Specifically, Ice‐Dissolving in water‐miscible organic solvent is responsible for pore creation, while subsequent Crosslinking ensures pore structures stabilization. The macro‐porous architecture of materials, taking sodium carboxymethyl cellulose (CMC) as a polyelectrolyte example and trimesoyl chloride (TMC) as the crosslinker, CMC‐TMCIDCr is made much stabler as compared with the case of conventional Lyophilization‐Crosslinking technique (CMC‐TMCLC). The IDCr method is applicable to various hydrophilic polyelectrolytes and hybrids for long‐time use in water and brines, as exemplified by CMC‐TMC‐carbon nanotubes monolith, which exhibits high performance in solar thermal desalination process. This novel approach opens up new opportunities for the construction of porous monoliths with efficient preparation and excellent water stability.
Continuous‐Flow Solution Plasma for the Atom‐Economic Synthesis of Single/Dual‐Atom Catalysts
Authors: Xing Yanmei , Wu Qi , Wang Changhua , Li Yuanyuan , Li Dashuai , Liang Shuang , Wang Rui , Ma He , Liu Yichun , Zhang Xintong 
Published: June 2024

AbstractSingle‐atom catalysts (SACs) manifest unique advantages in various aspects of catalysis but face challenges in atom‐economic synthesis. Solution reduction holds the promise of fast, continuous, and low‐cost synthesis of SACs, however, almost no chemical, electrochemical, or photochemical reduction can avoid the aggregation of metal atoms in solution. The issue becomes even tougher to composite dual‐atom metals together. Herein, a continuous‐flow solution plasma (CSP) method is developed, which utilizes high‐flux hydrated electrons, hydrogen radicals, and enhanced metal–support interaction, to achieve over 97% capture efficiency of metal precursors to fabricate CeO2‐based single‐atom Au, Rh, Pd, Ru, and Pt in only 0.03‐s residence time. Further, a programmed CSP synthesis of Au1Rh1/CeO2 and Au1Pd1/CeO2 dual‐atom catalysts is demonstrated. Under Xe lamp irradiation, Au1Rh1/CeO2 breaks room temperature constraints in CO conversion for the water–gas shift reaction with a T50 (the temperature at which 50% CO conversion occurs) of 298 K. The innovative CSP technology provides an atom‐economic approach to the continuous production of SACs using clean electricity without any additional reducing agent, paving the way for the programmed and green synthesis of SACs for industrial catalysis, energy conversion, and environment remedy applications.
Ionic Liquid‐Assisted One‐Step Large‐Scale Synthesis of Cs2ZrCl6:CDs Composites with Tunable Multicolor Afterglow Emission
Authors: Cao Mengyan , Zhao Xiujian , Gong Xiao 
Published: June 2024

AbstractThe strategy of utilizing all‐inorganic lead‐free perovskites as the matrix to form synergies with complementary functional nanomaterials has attracted great interest. In this study, a simplified one‐pot method that is employed to combine carbon dots with the all‐inorganic perovskites Cs2ZrCl6 to form a novel nano/microstructured composite is reported. The abundant functional groups on the surface of the carbon dots can effectively form coordination bonds with the Zr4+ ions in Cs2ZrCl6, realizing the effective dispersion of the carbon dots in the matrix. The composite not only introduces a synergistic interaction between carbon dots and Cs2ZrCl6, but also exhibits novel afterglow emission. This afterglow emission arises from the synergistic immobilization of triple excitons in a 3D spatially confined and rigid environment, thereby suppressing non‐radiative excitation processes. Tunable afterglow emission over the entire spectral range is achieved through control of the carbon source reactants, highlighting the outstanding versatility of this composite approach. This composite exhibits dual‐mode fluorescence and afterglow emission, holding tremendous potential for applications in information encryption and anti‐counterfeiting.
Formation and Detriments of Residual Alkaline Compounds on High‐Nickel Layered Oxide Cathodes
Authors: Cui Zehao , Zuo Peng , Guo Zezhou , Wang Chongmin , Manthiram Arumugam 
Published: June 2024

AbstractHigh‐nickel layered oxides LiNixM1‐xO2 (x ≥ 0.9) have emerged as promising cathode materials for automotive batteries due to their high energy density and lower cost. However, the formation and accumulation of surface alkaline compounds during storage hinder their mass production and commercialization. Here, a validated chemical method is employed to deconvolute and quantify the evolution of each residual lithium compound in four representative cathodes during ambient‐air storage, viz., LiNiO2 (LNO), LiNi0.95Co0.05O2 (NC), LiNi0.95Mn0.05O2 (NM), and LiNi0.95Al0.05O2 (NA). Furthermore, the activation energy of the reaction between water and the cathode is determined by measuring the leached LiOH concentration at various temperatures. While residual lithium and time‐of‐flight secondary‐ion mass spectrometry measurements collectively reveal that the air stability overall follows the trend of NM > NA ≈ NC > LNO, the aged NM exhibits the highest charge‐transfer resistance and the worst electrochemical performance among the cathodes. In situ, X‐ray diffraction and scanning transmission electron microscopy unveil that the aged NM is plagued by a large area of resistive spinel‐like M3–xLixO4 phases, leading to aggravated particle reaction heterogeneity. Finally, a one‐step recalcination method is demonstrated effective in fully restoring the degraded cathodes. This work provides insights into overcoming air sensitivity issues of high‐Ni cathodes.
Multicompartment Polyion Complex Micelles Based on Triblock Polypept(o)ides Mediate Efficient siRNA Delivery to Cancer‐Associated Fibroblasts for Antistromal Therapy of Hepatocellular Carcinoma
Authors: Schneider Paul , Zhang Heyang , Simic Leon , Dai Zhuqing , Schrörs Barbara , Akilli‐Öztürk Özlem , Lin Jian , Durak Feyza , Schunke Jenny , Bolduan Vanessa , Bogaert Bram , Schwiertz David , Schäfer Gabriela , Bros Matthias , Grabbe Stephan , Schattenberg Jörn Markus , Raemdonck Koen , Koynov Kaloian , Diken Mustafa , Kaps Leonard , Barz Matthias 
Published: June 2024

AbstractHepatocellular carcinoma (HCC) is the most frequent type of primary liver cancer and the third leading cause for cancer‐related death worldwide. The tumor is difficult‐to‐treat due to its inherent resistance to chemotherapy. Antistromal therapy is a novel therapeutic approach, targeting cancer‐associated fibroblasts (CAF) in the tumor microenvironment. CAF‐derived microfibrillar‐associated protein 5 (MFAP‐5) is identified as a novel target for antistromal therapy of HCC with high translational relevance. Biocompatible polypept(o)ide‐based polyion complex micelles (PICMs) constructed with a triblock copolymer composed of a cationic poly(l‐lysine) complexing anti‐MFAP‐5 siRNA (siMFAP‐5) via electrostatic interaction, a poly(γ‐benzyl‐l‐glutamate) block loading cationic amphiphilic drug desloratatine (DES) via π–π interaction as endosomal escape enhancer and polysarcosine poly(N‐methylglycine) for introducing stealth properties, are generated for siRNA delivery. Intravenous injection of siMFAP‐5/DES PICMs significantly reduces the hepatic tumor burden in a syngeneic implantation model of HCC, with a superior MFAP‐5 knockdown effect over siMFAP‐5 PICMs or lipid nanoparticles. Transcriptome and histological analysis reveal that MFAP‐5 knockdown inhibited CAF‐related tumor vascularization, suggesting the anti‐angiogenic effect of RNA interference therapy. In conclusion, multicompartment PICMs combining siMFAP‐5 and DES in a single polypept(o)ide micelle induce a specific knockdown of MFAP‐5 and demonstrate a potent antitumor efficacy (80% reduced tumor burden vs untreated control) in a clinically relevant HCC model.
The Enormous Potential of Sodium/Potassium‐Ion Batteries as the Mainstream Energy Storage Technology for Large‐Scale Commercial Applications
Authors: Gao Yanjun , Yu Qiyao , Yang Huize , Zhang Jianguo , Wang Wei 
Published: June 2024

AbstractCost‐effectiveness plays a decisive role in sustainable operating of rechargeable batteries. As such, the low cost‐consumption of sodium‐ion batteries (SIBs) and potassium‐ion batteries (PIBs) provides a promising direction for “how do SIBs/PIBs replace Li‐ion batteries (LIBs) counterparts” based on their resource abundance and advanced electrochemical performance. To rationalize the SIBs/PIBs technologies as alternatives to LIBs from the unit energy cost perspective, this review gives the specific criteria for their energy density at possible electrode‐price grades and various battery‐longevity levels. The cost ($ kWh−1 cycle−1) advantage of SIBs/PIBs is ascertained by the cheap raw‐material compensation for the cycle performance deficiency and the energy density gap with LIBs. Furthermore, the cost comparison between SIBs and PIBs, especially on cost per kWh and per cycle, is also involved. This review explicitly manifests the practicability and cost‐effectiveness toward SIBs are superior to PIBs whose commercialization has so far been hindered by low energy density. Even so, the huge potential on sustainability of PIBs, to outperform SIBs, as the mainstream energy storage technology is revealed as long as PIBs achieve long cycle life or enhanced energy density, the related outlook of which is proceeded as the next development directions for commercial applications.
Blue‐Emitting Boron‐ and Nitrogen‐Doped Carbon Dots for White Light‐Emitting Electrochemical Cells
Authors: Cavinato Luca M. , Kost Veronika , Campos‐Jara Sergi , Ferrara Sara , Chowdhury Sanchari , Groot Irene M.N. , Da Ros Tatiana , Costa Rubén D. 
Published: June 2024

AbstractThis work describes the first use of blue‐emitting boron‐ and nitrogen‐doped carbon dots (BN‐CDs), rationalizing their photoluminescence behavior in solution and ion‐based thin‐films to prepare white light‐emitting electrochemical cells (LECs). In detail, a cost‐effective and scalable water‐based microwave‐assisted synthesis procedure is set for BN‐CDs featuring an amorphous carbon‐core doped with N and B. While they show a bright (photoluminescence quantum yield of 42%) and excitation‐independent blue‐emission (440 nm) in solution related to emitting n−π* surface states, they are not emissive in thin‐films due to aggregation‐induced quenching. Upon fine‐tuning the film composition (ion‐based host), an excitation dependent emission covering the whole visible range is noted caused by interaction of the ion electrolyte with the peripheral functionalization of the BN‐CDs. Moreover, the efficient energy transfer from the host to the BN‐CDs emitting species enabled good performing LECs with white emission (x/y CIE coordinates of 0.30/0.35, correlated color temperature of 6795 K, color rendering index of 87) and maximum luminance of 40 cd m−2, and stabilities of a few hours. This represents a significant improvement compared to the prior‐art monochromatic CD‐based LECs with similar brightness levels, but stabilities of <1 min.
The Rise of 2D Materials‐Based Photoelectrochemical Photodetectors: Progress and Prospect
Authors: Zhou Junxin , Zhang Nana , Liu Jiaming , Gao Qiyue , Zhang Yuan , Gao Feng , Hu PingAn , Feng Wei 
Published: June 2024

Abstract2D materials have garnered significant research attention due to their unique electrical and optical properties. Various photodetectors (PDs) based on 2D materials have been demonstrated to possess a high photoresponse, achieve specific light detection, and construct flexible devices. Among these, photoelectrochemical‐type (PEC) PDs are attracting increasing attention due to their facile fabrication processes, self‐powered capability, and high sensitivity. Compared with transitional solid‐state PDs based on 2D materials, research on 2D material‐based PEC PDs is still in its initial stages but exhibits promising potential for various applications. This paper comprehensively reviews recent advancements in 2D material‐based PEC PDs. The 2D materials for PEC PDs are first classified, and then the synthesis methods employed for their fabrication are briefly summarized. Later, the performance and performance optimization strategies of various 2D material‐based PEC PDs are discussed. Finally, the challenges and opportunities for developing high‐performance 2D material‐based PEC PDs are highlighted.