bluuebunny/crossref_metadata_2025_split huggingface dataset:
Astrocytes adopt a progenitor-like migratory strategy for regeneration in adult brain
Authors: Herwerth Marina , Wyss Matthias T. , Schmid Nicola B. , Condrau Jacqueline , Ravotto Luca , Mateos Melero José María , Kaech Andres , Bredell Gustav , Thomas Carolina , Stadelmann Christine , Misgeld Thomas , Bennett Jeffrey L. , Saab Aiman S. , Jessberger Sebastian , Weber Bruno 
Published: May 2024

AbstractMature astrocytes become activated upon non-specific tissue damage and contribute to glial scar formation. Proliferation and migration of adult reactive astrocytes after injury is considered very limited. However, the regenerative behavior of individual astrocytes following selective astroglial loss, as seen in astrocytopathies, such as neuromyelitis optica spectrum disorder, remains unexplored. Here, we performed longitudinalin vivoimaging of cortical astrocytes after focal astrocyte ablation in mice. We discovered that perilesional astrocytes develop a remarkable plasticity for efficient lesion repopulation. A subset of mature astrocytes transforms into reactive progenitor-like (REPL) astrocytes that not only undergo multiple asymmetric divisions but also remain in a multinucleated interstage. This regenerative response facilitates efficient migration of newly formed daughter cell nuclei towards unoccupied astrocyte territories. Our findings define the cellular principles of astrocyte plasticity upon focal lesion, unravelling the REPL phenotype as a fundamental regenerative strategy of mature astrocytes to restore astrocytic networks in the adult mammalian brain. Promoting this regenerative phenotype bears therapeutic potential for neurological conditions involving glial dysfunction.
A multi-year longitudinal harmonization of quality controls in mass spectrometry proteomics core facilities
Authors: Chiva Cristina , Olivella Roger , Staes An , Maia Teresa Mendes , Panse Christian , Stejskal Karel , Douché Thibaut , Lombard Bérangère , Schuhmann Andrea , Loew Damarys , Mechtler Karl , Matondo Mariette , Rettel Mandy , Helm Dominic , Impens Francis , Devos Simon , Shevchenko Anna , Nanni Paolo , Sabidó Eduard 
Published: May 2024

AbstractQuality control procedures play a pivotal role in ensuring the reliability and consistency of data generated in mass spectrometry-based proteomics laboratories. However, the lack of standardized quality control practices across laboratories poses challenges for data comparability and reproducibility. In response, we conducted a harmonization study within proteomics laboratories of the Core for Life alliance with the aim to establish a common quality control framework, which facilitates comprehensive quality assessment and identification of potential sources of performance drift. Through collaborative efforts, we developed a consensus quality control standard for longitudinal assessment and we adopted a common processing software. We generated a 4-year longitudinal dataset from multiple instruments and laboratories, which enabled us to assess intra- and inter-laboratory variability, to identify causes of performance drift, and to establish community reference values for several quality control parameters. Our study enhances data comparability and reliability and fosters a culture of collaboration and continuous improvement within the proteomics community to ensure the integrity of proteomics data.
Streptococcusabundance and oral site tropism in humans and non-human primates reflects host and lifestyle differences
Authors: Velsko Irina M. , Warinner Christina 
Published: May 2024

AbstractThe genusStreptococcusis highly diverse and a core member of the primate oral microbiome.Streptococcusspecies are grouped into at least eight phylogenetically-supported clades, five of which are found almost exclusively in the oral cavity. We explored the dominantStreptococcusphylogenetic clades in samples from multiple oral sites and from ancient and modern-day humans and non-human primates and found that clade dominance is conserved across human oral sites, with most species falling in the Sanguinis or Mitis clades. However, minor differences in the presence and abundance of individual species within each clade differentiated human lifestyles, with loss ofS. sinensisappearing to correlate with toothbrushing. Of the non-human primates, only baboons show clade abundance patterns similar to humans, suggesting that a habitat and diet similar to that of early humans may favor the growth of Sanguinis and Mitis clade species.
Sustainable water resource management by business organisations: empirical investigation applying stimulus-organism-response theoretical perspective
Authors: Ellsworth Chad , Arghode Vishal , Bhattacharyya Som Sekhar , Barker David , Schuhmann Richard 
Published: May 2024

PurposeThe purpose of this research was to study sustainable water resource management using a stimulus-organism-response (SOR) perspective.Design/methodology/approachThis research study was an exploratory qualitative study. Thematic content analysis was used based on semi-structured interviews with 30 experts operating in the USA, representing 26 water-intensive organisations across different industries. The study was anchored in the theoretical foundations of SOR perspectives.FindingsThe results of this study revealed several fundamental factors, processes and forces that were considered by organisations for sustainable water resource management. Managers evaluated risks relative to water resources and developed strategic initiatives regarding water management. The authors found that often organisations considered water resources management aspects while deciding business operations. This was especially true for substantive water resource-consuming organisations with wide geographical operations.Research limitations/implicationsThrough this study, the authors explained how the interrelationship between organisations and water resources presented risks and challenges. The authors applied SOR theoretical perspective in this research study. This was while factoring in an organisation’s present considerations and future plans regarding sustainable water resource management. Thus, the study findings were expected to further interdisciplinary research at the intersection of organisational and environmental studies.Practical implicationsThe finding that water sustainability challenges and efforts could act as strong motivating forces for innovation and technology was significant. Water sustainability challenges could also be a catalyst for synergistic collaborations amongst organisations and diverse groups of institutions. The study insights were relevant to organisational scholars, the water management industry regulators and managers involved with organisational sustainability programmes.Originality/valueOrganisational challenges regarding sustainable water resource management have been influenced by growing populations and climate change. Furthermore, the increasing context of scarcity was compounded by increased pressures from numerous stakeholders. Although critical water management issues were recognised by organisations, relatively little was known about how organisational managers were planning for and responding to these issues. This research study contributed towards addressing the mentioned research gap.
Radical pluralism, high inflation, and trust in historical context: the continued relevance of Fox in understanding UK public sector strikes
Authors: Simms Melanie 
Published: May 2024

PurposeThe paper uses key themes from Fox’s writing to reflect on the wave of public sector industrial action that developed in the UK since the early 2020s: specifically the relevance of (1) radical pluralism, (2) historical context, (3) understanding the effects of high inflation and (4) (a breakdown of) trust relations.Design/methodology/approachThe paper draws primarily on evidence from broad public debate but is informed by discussions held with senior union leaders both for a research project and in delivering development training.FindingsRadical pluralism is used as a lens through which to understand declining trust in institutions of pluralist collective industrial relations in the UK public sector, arguing that current developments need to be understood in historical context. An analysis of the industrial action in the early 2020s highlights the ways that a period of high inflation can stress institutions of collective employment regulation, rendering visible the limits of conventional, pluralist industrial relations.Research limitations/implicationsThe paper could be extended by more detailed empirical data collection, both in the UK and other national institutional contexts.Practical implicationsUnions need to more consistently focus on issues of power. A stronger focus on power might identify the limitations of pluralist institutions of collective regulation and embed a commitment to building union influence to challenge those existing structures in favour of mechanisms to build workers' power more broadly.Social implicationsUnderstanding these disputes as, at least in part, being about the limits to and undermining of trust in collective institutions that regulate work and employment allows us to better understand the forces at play and potential outcomes of these disputes.Originality/valueThe paper makes three key contributions: first, applying Fox’s work in a practical way to contemporary UK industrial relations; second, extending his analyses to public sector industrial relations and third, arguing that power needs to be more centrally located within union objectives in order to reshape industrial relations to radical pluralist ends.
The motivation of employees and their intention to work in the Greek tourism sector
Authors: Kafetzopoulos Dimitrios 
Published: May 2024

PurposeThe purpose of this study is to investigate the motives that drive individuals' intentions to work within firms operating in the Greek tourism sector and to examine the impact of these motives on the intention to work.Design/methodology/approachTo achieve this objective, we conducted an empirical survey among 2,104 individuals with professional experience in the tourism business. Descriptive statistics and hierarchical regression analysis were employed, with motives as independent variables and the intention to work as the dependent construct, to answer the research question.FindingsThis study presents job motivation as a hierarchical set of criteria that need to be fulfilled or satisfied. It also identifies the significant motives impacting employees' intention to work in both the accommodation sector and food and beverage services.Research limitations/implicationsThe data were collected at a single point in time from Greece, which may limit the generalizability of our results. Future research could consider the psychological and physiological characteristics of employees.Practical implicationsManagers who provide social security, create a positive work environment, and promote collaboration among their employees can enhance the quality of work-life and positively influence their intention to work.Originality/valueThe proposed model offers valuable guidelines that advance research on employee motivation in the tourism industry.
Optimal new product design using reverse quality function deployment with nonlinear regression modeling
Authors: Wang Jian , Tan Yi , Zhang Jingzhi , Han Yajuan 
Published: May 2024

PurposeQuality function deployment (QFD) has been widely applied in new product development, but existing research on QFD has some limitations. Primarily, QFD lacks the capability to provide feedback on the satisfaction degree of customer requirements (CRs) according to the actual values of engineering characteristics (ECs). In addition, QFD does not quantitatively consider the interrelationships among ECs. Reverse QFD (R-QFD) was introduced to implement the feedback process. On this basis, this paper quantitatively considers the interrelationships among ECs in the R-QFD model and extends these relationships to encompass combinations of multiple ECs, aiming to improve the inference accuracy of the model.Design/methodology/approachA nonlinear regression model was established between CRs and ECs, aiming to infer the satisfaction degree of CRs based on the implementation status of ECs. This model considers the interdependencies among ECs and extends the consideration of pairwise EC correlations from every two to every fifteen. Lingo Software is utilized to seek solutions for this program. To facilitate the implementation of the program, a directive to simplify the solution has been proposed.FindingsThe experimental results indicate that the interrelationships among ECs significantly affect the inference accuracy of the R-QFD model, thereby verifying the necessity of considering higher-order interrelationships among ECs within the R-QFD framework. Based on the results from data experiments, this paper also proposes research recommendations pertaining to ECs hierarchy for varying quantities of ECs.Originality/valueThe outcomes of this study have further refined the R-QFD model, addressing its limitations of ignoring the interrelationships among ECs. This transformation elevates the R-QFD model from a relatively simple linear model to a nonlinear model formed through modeling, thereby enhancing its accuracy and applicability. In practical terms, this study provides case support for the application of the R-QFD model in manufacturing industry.
Nudge theory on intrapreneurship: a conceptual view
Authors: Öztürk Alperen , Arun Korhan 
Published: May 2024

Purpose
This study aims to discuss appropriate individual, organizational and macroleveled conditions when it is desired to foster intrapreneurship with nudge techniques.

Design/methodology/approach
Conceptual paper.

Findings
This paper aims to provide theoretical framework on the relationship between nudges approach and intrapreneurship and offer measurable propositions at different level of analysis for future research.

Originality/value
At the individual level it is theorized that nudges techniques on intrapreneurship will work when: “agents are aware of being nudged”, “choice architect is a well-recognized leader”, “perception of meaningful work is high” and “agents had former experience about being nudged”. At the organizational level it is claimed that the “number”, “type” and “frequency” of nudges plays the prominent role. Lastly, at the macrolevel it is postulated that “cultural adjustments”, “providing education” and “forming networks” sets the ground for pushing masses to intrapreneurial activities via nudges.
The perceived effect of digital transformation and resultant empowerment on job performance of employees in the fitness family business
Authors: Yildiz Kadir , Akoğlu Halil Erdem , Emir Esra , Angosto Salvador , García-Fernández Jerónimo 
Published: May 2024

PurposeThe impact of technological transformations in all sectors is undeniably significant, especially in fitness family business. The aim is to examine the digital transformation perceptions of fitness centre employees and the effects of perceived empowerment on their job performance in family business in Turkey.Design/methodology/approachThe sample was 334 fitness centre employees. Four variables were evaluated (digital transformation, meaning competence, self-determination and job performance), and PLS-SEM was used.FindingsThe digital transformation process in the fitness sector can be considered as an important factor in terms of creating new business ventures. Our results showed that digital transformation perceived by family business employees had a significantly influence on the meaning competence of the employees. Also, the meaning competence of employees was a mediator between the digital transformation and job performance.Practical implicationsManagers of family businesses must take into account that an appropriate digital transformation of their products and/or services has an impact on the meaning competence of their employees. Thus, through increased competence in employee performance, the digitization of family business fitness will lead to higher employee performance and productivity.Originality/valueThis study innovates by linking digital transformation as a factor influencing the coach's own motivation and self-perceived competence in the use of technology to their job performance.
UNRAVELLING THE ROLES OF ACTIVE RESIDENTS IN A POLITICALLY CHALLENGING CONTEXT: An Exploration in Cairo
Authors: Elwageeh Aya , Van Ham Maarten , Kleinhans Reinout 
Published: May 2024

AbstractCapital cities struggle with population growth that challenges existing infrastructure and affects the quality of urban life. The failure of local governments to manage urban deterioration motivates active resident groups to improve their neighborhoods, but they struggle to play a role in neighborhood governance in contexts where citizens’ engagement in public affairs is restricted. In this article we aim to understand active residents’ roles in the neighborhood governance process and how these roles unfold in a context that challenges citizen engagement in public life. We adopted a case study methodology and interviewed active residents and local officials from selected districts in Cairo, which revealed that active residents’ influence is limited mostly to neighborhood management and implementation activities. In this limited space, the role of active residents is confined to either that of the ‘fixer’ who restores existing services, or that of the struggling and intermittent ‘self‐provider’, neither of whom can influence policy formulation. This study provides a structured and zoomed‐out view of local activism in Cairo, offering a starting point for scholars and decision makers seeking to enhance active residents’ roles in Cairo.
Stakeholder engagement in managing systemic risk management
Authors: Iandolo Francesca , La Sala Antonio , Turriziani Lorenzo , Caputo Francesco 
Published: May 2024

AbstractThis paper employs the interpretative lens provided by stakeholder theory to garner novel insights for research and managerial practices within the framework of high‐reliable organizations (HROs). It proposes an interpretative matrix for analyzing and explaining how stakeholders’ behaviors and interactions can transition from a “strategic” to a “responsibility” approach in the context of risk management. The paper adopts a qualitative methodology based on a case study of the Italian Civil Protection—an HRO—during the COVID‐19 pandemic. Through the analysis of institutional sources and reports, we apply two theoretical frameworks to examine how the organization's engagement strategy changed in response to an unexpected event. This case serves to illuminate the main implications and practical applications of shared conceptual reflections. The principal implications are traced in terms of theory, practice, and policy, focusing on the joint examination of organizational reliability and stakeholder engagement theory, the potential utility of the proposed case study, and the feasible policy actions. The main limitations of this study lie in the purely qualitative methodology employed, the nature of the organization analyzed, and the territorial scope of the study. Future works will address an empirical investigation of the theoretical relations uncovered herein, as well as the expansion of the spectrum of analysis (e.g., private organizations) and a cross‐country widening of the level of analysis.
When facts become feelings
Authors: Abernathy Alice M. 
Published: May 2024

AbstractI have long maintained that equipoise between empathy and the rational, decisive nature of obstetric care is central to good doctoring. I had exacting standards for how to communicate facts with feeling while shielding my own. Then, after experiencing my own obstetric emergency and preterm birth, this changed. In this reflection, I explore how recognizing the intersections between facts and feelings has made me a better physician.
Children's attitudes about transgender identity disclosure and concealment
Authors: Alonso Daniel J. , Jordan Ashley E. , Gülgöz Selin 
Published: May 2024

AbstractSupportive peers are crucial for transgender children's well‐being. Transgender children who live in their affirmed gender face decisions surrounding concealment and disclosure of their transgender identity. We sought to understand how cisgender (N = 115) and gender‐diverse children (N = 127), and siblings of gender‐diverse children (N = 63) think about transition disclosure and concealment. All groups viewed transition disclosure and concealment positively. However, gender‐diverse children showed greater acceptance of transition concealment and had stronger liking of transition concealers (relative to non‐transition concealers). Additionally, children generally expected transgender peers to be selective about who they disclose to, valuing trustworthiness and diverse friend groups in such decisions. Our findings suggest that regardless of gender identity, children are sensitive to the potential costs of disclosure and may support trans children however they choose to navigate these decisions.
Child‐led goal setting and evaluation tools for children with a disability: A scoping review
Authors: Ryan Aisling K. , Miller Laura , Rose Tanya A. , Johnston Leanne M. 
Published: May 2024

AbstractAimTo examine child‐led goal setting and evaluation tools and approaches for children with a disability or developmental delay.MethodSix databases were searched for studies that included population (children aged less than 18 years with disability or developmental delay); construct (child‐led goal setting tool or approach); and context (developmental therapy or rehabilitation). The utility of tools and approaches across the goal setting and evaluation process was investigated using abductive content analysis.ResultsFifty articles met the inclusion criteria. Three approaches and four tools for child‐led goal setting and evaluation were identified. No studies reported the clinimetric properties of tools specifically for child self‐respondents. Qualitative analysis revealed six distinct goal phases in which tools and approaches were used, which were synthesized into a new framework for child‐led goal setting and evaluation titled DECIDE: Direct children to goal setting; Elicit goal topics and priorities; Construct a goal statement; Indicate baseline goal performance; Develop an action plan to address the goal; and Evaluate goal progress after the intervention.InterpretationChildren actively participated in goal setting and evaluation across six DECIDE goal phases. Further clinimetric information is required to support use of goal setting and evaluation tools with child self‐respondents. Future research should emphasize the development of multi‐phase goal setting tools and approaches for diverse populations of children.