bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiological and Functional Outcomes of Bone Transport in Lower-extremity Long-bone Segmental Bone Loss Using Rail Fixator
Authors: Dhawan Manish , Arvind Navneet , Nandan Brajesh , Thakur Kamparsh , Prasad Manish 
Published: June 2024

Background:
Segmental bone loss in the femur and tibia is most often due to traumatic bone loss, resection of septic and aseptic nonunion, and resection of bone tumors. Reconstruction of these segmental defects incurs significant economic and social costs. The segmental bone defect has been treated with Masquelet’s induced membrane technique and bone transport using the Ilizarov circular external fixator and six-axis correction systems. Similarly, rail fixators for bone transport are an excellent and viable alternative for such cases.

Materials and Methods:
This ambispective observational study was done in 50 patients with segmental bone loss of the femur or tibia with a mean age of 34 years (range: 17–56 years) and operated with rail fixator application and underwent bone transport between January 2015 and October 2020. The functional and radiological outcomes were assessed. The outcomes were assessed using the Association for the Study and Application of the Methods of Ilizarov functional and bone criteria. The radiological outcomes were the bone healing index, distraction duration, and consolidation duration, which were assessed using regular postoperative radiographs.

Results:
The mean bone defect was 7.01 cm (range: 5–9.5 cm). The mean healing index was 35.92 days/cm. The mean distraction duration was 11.86 weeks (range: 7–24 weeks), and the mean consolidation duration was 22.94 weeks (range: 15–49 weeks). The mean time in the frame was 35.8 weeks (23–74 weeks). The most common complication was pin tract infection (12/50), followed by knee stiffness, ankle stiffness, and pin loosening. The functional results were excellent, good, and fair in 26, 22, and two patients, respectively. The bone results were excellent, good, and fair in 29, 17, and four patients, respectively.

Conclusion:
Segmental bone defects in the lower limb are difficult clinical scenarios to manage, which need a meticulous and deliberate approach while planning and execution of surgery. The surgical procedure of rail fixator application is simple; the learning curve is not steep, and patient acceptance is good with good to excellent functional and bone results.
Educational and Training Opportunities on Limb Deformities for Surgeons and Trainees in Low- and Middle-income Countries: Hardly Any Peer-reviewed Studies
Authors: Flores Michael J. , Brown Kelsey E. , Simister Samuel K. , Sabharwal Sanjeev 
Published: June 2024

Context:
Orthopedic education and training can increase surgical capacity and improve clinical outcomes in low- and-middle income countries (LMICs).

Aims:
We aimed to identify the published reported outcomes of education and training programs pertaining to limb deformities in LMICs.

Settings and Design:
A state-of-the-art review was conducted using seven databases (Africa-Wide Information, Aim, CINAHL, Embase, Global Health, Medline, and Web of Science).

Subjects and Methods:
The search included articles with keywords related to limb deformities AND education AND LMICs published between 2017 and 2021. The search yielded 4511 articles for the title and abstract screening. Screening yielded eight articles for full-text review and three articles for extraction. Data on the mechanics, topics, and outcomes of each educational opportunity were extracted using REDCap.

Statistical Analysis Used:
This was a state-of-the-art review.

Results:
Three studies met inclusion criteria. The studies were published from 2018 to 2020 and based on the African continent, with partners from the US and UK. Study designs included retrospective comparative, systems approach, and mixed methods all with level IV level of evidence. One study was conducted virtually, with 259,986 viewers of video-based content created by medical students related to various orthopedic topics, including limb deformities. The other two studies were related to an in-person clubfoot training program with 113–185 participants. These two studies included pre- and posttraining evaluation, with outcomes related to participation, knowledge gained, and efficacy. All the studies reported an overall positive effect of the intervention.

Conclusions:
There is limited available information regarding limb deformity educational interventions in LMICs. The current review suggests a positive impact of such educational interventions and emphasizes a need for more research on the topic.
Polyethylene glycol fusion repair of severed rat sciatic nerves reestablishes axonal continuity and reorganizes sensory terminal fields in the spinal cord
Authors: Hibbard Emily A. , Zhou Liwen , Yang Cathy Z. , Venkudusamy Karthik , Montoya Yessenia , Olivarez Alexa , Bittner George D. , Sengelaub Dale R. 
Published: June 2024

JOURNAL/nrgr/04.03/01300535-202507000-00030/figure1/v/2024-09-09T124005Z/r/image-tiffPeripheral nerve injuries result in the rapid degeneration of distal nerve segments and immediate loss of motor and sensory functions; behavioral recovery is typically poor. We used a plasmalemmal fusogen, polyethylene glycol (PEG), to immediately fuse closely apposed open ends of severed proximal and distal axons in rat sciatic nerves. We have previously reported that sciatic nerve axons repaired by PEG-fusion do not undergo Wallerian degeneration, and PEG-fused animals exhibit rapid (within 2–6 weeks) and extensive locomotor recovery. Furthermore, our previous report showed that PEG-fusion of severed sciatic motor axons was non-specific, i.e., spinal motoneurons in PEG-fused animals were found to project to appropriate as well as inappropriate target muscles. In this study, we examined the consequences of PEG-fusion for sensory axons of the sciatic nerve. Young adult male and female rats (Sprague–Dawley) received either a unilateral single cut or ablation injury to the sciatic nerve and subsequent repair with or without (Negative Control) the application of PEG. Compound action potentials recorded immediately after PEG-fusion repair confirmed conduction across the injury site. The success of PEG-fusion was confirmed through Sciatic Functional Index testing with PEG-fused animals showing improvement in locomotor function beginning at 35 days postoperatively. At 2–42 days postoperatively, we anterogradely labeled sensory afferents from the dorsal aspect of the hindpaw following bilateral intradermal injection of wheat germ agglutinin conjugated horseradish peroxidase. PEG-fusion repair reestablished axonal continuity. Compared to unoperated animals, labeled sensory afferents ipsilateral to the injury in PEG-fused animals were found in the appropriate area of the dorsal horn, as well as inappropriate mediolateral and rostrocaudal areas. Unexpectedly, despite having intact peripheral nerves, similar reorganizations of labeled sensory afferents were also observed contralateral to the injury and repair. This central reorganization may contribute to the improved behavioral recovery seen after PEG-fusion repair, supporting the use of this novel repair methodology over currently available treatments.
Profile of multi-system inflammatory syndrome in children related to COVID-19
Authors: Bhattad Sagar , Ramya Sadashiva , Unni Jeeson C. , Kumar Suresh , Pillai Rajappan , Cyril Gladys , Paul George , Kumar Sathish , Arigela Karthik , Naushad Syed M. , Anand Manjula , Anirudhan Vinitha 
Published: June 2024

Background:
Multi-system inflammatory syndrome in children (MIS-C) is a severe complication of SARS-COV-2 infection associated with significant morbidity and can be fatal if left unrecognized.

Objectives:
The aim of this article is to evaluate the clinical profile of children admitted with MIS-C associated with SARS-CoV-2 infection.

Materials and methods:
A retrospective multi-centric study was carried out at three tertiary care centers in South India. Cases of MIS-C diagnosed during October 2020–April 2021 were included. Diagnosis of MIS-C was based on WHO criteria. All children underwent echocardiography at admission, discharge, and 4–6 weeks of follow-up. We also compared younger children (<7 years of age) with older ones to determine whether age at presentation could predict severity in children with MIS-C.

Results:
A total of 41 children were diagnosed to have MIS-C during the study period. The mean age of presentation was 6 years. About 31.7% of the children had shock at admission and 43% of them had myocardial dysfunction. The average duration of PICU stay was 7 days. Anti-SARS-CoV-2 antibodies were found to be positive in 75% percentage of patients. Children with high N-terminal pro-brain natriuretic peptide had more severe presentation. All children responded promptly to intravenous immunoglobulins and steroids. No difference was noted in terms of outcome between younger (< 7 years) and older children.

Conclusion:
A significant proportion of children with MIS-C present with shock and myocardial dysfunction. Anti-SARS-CoV-2 antibodies were positive in 75% of children whose primary infection went unnoticed.
Efficient reduction of peak‐to‐average power ratio in multiple‐input multiple‐output orthogonal frequency‐division multiplexing system by shuffling cluster sequences
Authors: Mi Si Sar , Mata Tanairat , Boonsrimuang Pornpawit , Boonsrimuang Pisit 
Published: June 2024

AbstractWe propose a shuffling cluster sequence technique without separate side information (SI) for multiple‐input multiple‐output (MIMO) orthogonal frequency‐division multiplexing (OFDM) systems. In the proposed technique, the active subcarriers over two consecutive OFDM symbols are divided into
clusters, and each cluster (packet frame) includes a header for ID#cluster and payload for
. The
clusters are shuffled to reduce the peak‐to‐average power ratio (PAPR) of the time‐domain OFDM signal, which includes the information data and SI signals, with a low computational complexity. At the receiver, the information data can be correctly reconstructed by ID#cluster in the header of each cluster, achieving a smaller bit error rate than the conventional MIMO‐OFDM system without PAPR reduction. Moreover, our technique is comparable with the conventional partial transmit sequence technique without the impact of a separate SI signal even when increasing the number of transmitter antennas in a nonlinear multipath fading channel.
O estudo da cidade
Authors: Callai Helena Copetti , Kohn Neuza Beatriz Prestes 
Published: June 2024

Este ensaio aborda o estudo da cidade realizado pela pesquisa bibliográfica, considerando como a modernidade líquida impacta a vida na cidade e nos seus cidadãos, tendo como base os conceitos de espaço, paisagem, tempo, lugar, pertencimento e identidade. Possibilita pensar em como abordar estes conceitos na Educação Básica, em aulas de Geografia, tendo a cidade como um tema interdisciplinar, inter-relacionando a paisagem urbana e as casas dos alunos. A intenção passa por apontar possíveis alternativas para melhorar a vida nas cidades e dar maior significação para a história das periferias, tendo como foco as escolas e as praças dos respectivos bairros onde os alunos residem.

The study of the city: places to create a critical view on the world today
Abstract
This essay delves into the exploration of urban environments through comprehensive bibliographic research, examining the profound impact of liquid modernity on city life and its inhabitants. It is anchored in fundamental concepts such as space, landscape, time, place, belonging, and identity. The study aims to propose innovative approaches for integrating these concepts into basic education Geography classes, treating the city as a compelling interdisciplinary subject that intertwines urban landscapes with the homes of students. The overarching goal is to present viable alternatives for enhancing urban life and providing deeper significance to the histories of peripheral areas, with a specific emphasis on schools and public spaces within the respective neighborhoods where students reside.
Keywords
City; Geographic education; Geography; Urban landscape

El estudo de la ciudad: lugares para mirar crítico acerca del mondo actual
Resumen
El ensaio trata del estúdio de la Ciudad por la investigacón bibliográfica, considerando como la modernidad liquida impacta la vida en la Ciudad e con sus ciudadanos, con base en los conceptos de espacio, paisaje, tiempo, lugar, pertinência y identidad. Lleva a pensar la abordaje de los conceptos en la Educación Básica, en las aulas de Geografia, teniendo la ciudad como un tema interdisciplinar, ligando la paisaje urbana e las vivendas de los alumnos . La intención es señalar posibles alternativas para mejorar la vida en las ciudades con atención a la periferia centrándose en las escuelas y plazas de los respectivos barrios donde viven los estudiantes.
Palabras clave
Ciudad; Educación geográfica; Geografía; Paisaje urbana.
Perlindungan Hukum Terhadap Tertanggung Dalam Bentuk Penolakan Klaim Polis Asuransi Yang Telah Diberikan Ke Otoritas Jasa Keuangan
Authors: Febriyanti Emilia , Sri Widiarty Wiwik , Tehupeiory Aartje 
Published: June 2024

Perusahaan asuransi menanggung pertanggungan selama pengangkutan dari pelabuhan hingga ke tempat tujuan. Penelitian ini bertujuan untuk memahami dan menganalisis upaya dan hambatan Otoritas Jasa Keuangan terhadap penyelesaian sengketa tentang penolakan klaim polis asuransi, mengkaji dan menganalisa tentang kewenangan Otoritas Jasa Keuangan dalam perlindungan hukum terhadap tertanggung dalam penolakan klaim polis asuransi. Teori yang digunakan ialah Teori keadilan, teori perlindungan hukum dan teori pertanggungjawaban hukum. Metode yang diterapkan dalah kajian metode penelitian yuridis normatif. Pendekatan penelitian yang digunakan dalam penelitian ini Pendekatan Undang-Undang (Statue Approach) dan Pendekatan analitis (Analytical Approach). Hasil Penelitian upaya pemberian perlindungan hukum terhadap tertanggung khususnya dalam penolak klaim polis asuransi yang diajukan ke Otoritas Jasa keuangan. Otoritas Jasa Keuangan dalam melakukan prinsip – prinsip pelaksanaannya, antara lain: Prinsip Transparansi, Prinsip Perlakuan yang adil, Prinsip Keadilan, Prinsip Kerahasiaan dan Keamanan Data, Prinsip Penanganan Pengaduan dan Hambatan yang dihadapi adalah Kendala Internal, meliputi Pengaduan yang disampaikan nasabah kurang jelas dan Bukti pengaduan berupa dokumen pendukung yang disampaikan kurang lengkap, kendala Eksternal, yaitu: Kurangnya Informasi yang didapat dan Kurangnya pemahaman Tertanggung terhadap produk-produk asuransi yang ingin dilakukan. Serta, Otoritas Jasa Keuangan berfungsi menyelenggarakan sistem pengaturan dan pengawasan terintegrasi terhadap keseluruhan kegiatan dalam sektor jasa keuangan di Indonesia. Kesimpulan: kewenangan Otoritas Jasa Keuangan dalam memberikan perlindungan hukum terhadap Tertanggung dalam penolakan klaim asuransi asuransi, yaitu dengan memberikan perlindungan hukum preventif dan represif.
The Importance of Camel Milk and Its Health Benefits
Authors: Hasen Iman Jaber 
Published: June 2024

Camel milk's distinctive nutritional qualities and possible health advantages are making it famous around the globe. All around the semi-arid and dry world, people have been considering it as a potential medicinal and nutritional food source. Cow and camel milk are chemically similar; both contain a lot of fat, mostly medium-chain fatty acids, very little lactose, and plenty of iron and vitamin C. It is widely believed that camel milk and its derivatives have antidiabetic, anti-cancer, and antihypertensive effects, among numerous other beneficial health effects. Some of the potential scientific explanations for camel milk's health benefits have been uncovered by various in vitro and in vivo investigations. These include the presence of bioactive proteins (such as lactoferrin, immunoglobulins, and lactoperoxidases) and the production of bioactive peptides during digestion. Scientists and health nuts alike have taken an interest in camel milk for its unusual nutritional qualities and possible medicinal uses. Scientific investigations into camel milk's many medicinal, nutritional, and economic uses have yielded promising results. The purpose of this research is to analyse camel milk and investigate its significance while also discussing its many components, benefits, and advantages in terms of health.
CANDIDEMIA, UMA BREVE REVISÃO BIBLIOGRÁFICA
Authors: Da Silva Jefferson Vinicius , Ribeiro Dias Fátima , Correa Amaral Andre 
Published: June 2024

Candidemia é considerada uma das complicações das infecções causadas por fungos do gênero Candida em pacientes hospitalizados, resultando em altas taxas de mortalidade e morbidade. Trata-se de um processo infeccioso sistêmico originado por espécies do gênero Candida, sendo reconhecido como a quarta causa mais prevalente de infecções sanguíneas. O objetivo deste estudo consiste em realizar uma revisão concisa da literatura abordando temas como candidemia, resistência, fatores de virulência, diagnóstico e tratamento. Para isso, foi realizada revisão de literatura com análise de dados secundários sobre candidemia em pacientes hospitalizados. Foram utilizados diversos repositórios, como BVS Brasil, Scielo, Pubmed, LILACS, Elsevier e Medline, com descritores específicos. Foram incluídos 29 estudos em português, inglês e espanhol no período de 2018 a 2023, abrangendo artigos de estudo de caso, estudo clínico e revisão sistemática, enquanto trabalhos fora desse período e critérios foram excluídos. A revisão de literatura destaca a crescente preocupação com a candidemia devido à sua alta morbidade e mortalidade, especialmente em pacientes hospitalizados. Diante da diversidade de espécies de Candida e seus fatores de virulência, como a Candida auris, abordagens multidisciplinares com avaliação clínica, culturas laboratoriais e técnicas moleculares são cruciais para diagnóstico e tratamento eficazes, requerendo monitoramento epidemiológico para orientar estratégias de controle e prevenção.
Efficacy of statin therapy in reducing epicardial adipose tissue: a systematic review and meta-analysis
Authors: Jamialahmadi Tannaz , Simental-Mendia Luis E. , Eid Ali H. , Almahmeed Wael , Salehabadi Sepideh , Al-Rasadi Khalid , Banach Maciej , Sahebkar Amirhossein 
Published: June 2024

IntroductionUnderstanding the effect of statins on epicardial adipose tissue (EAT) is important as it may help reduce the negative impact of EAT-derived molecules on the cardiovascular system and consequently on coronary artery disease. Thus, we aimed to perform a systematic review and meta-analysis to assess the impact of statin therapy on EAT.MethodsThe study utilized Scopus, PubMed, Embase, and Web of Science to gather relevant studies on the impacts of statins on EAT until September 5th, 2023. The data collected underwent meta-analysis using Comprehensive Meta-Analysis (CMA) V4 software.ResultsIn the meta-analysis, three studies involving 512 subjects were ultimately incorporated. The findings indicated a significant decrease in EAT after treatment with statins (standardized mean difference (SMD = –0.507, 95% CI: –2.536, 1.521, p = 0.021).ConclusionsStatins appear to exert an additional cardiovascular therapeutic effect by reducing EAT.
Analisis Level Berpikir Geometris Siswa SMP dalam Menyelesaikan Soal Lingkaran Berdasarkan Teori Van Hiele
Authors: Umami Insan Nuri , Asdarina Orin 
Published: June 2024

Setiap siswa memiliki kemampuan berpikir geometris yang berbeda-beda, namun masih sedikit temuan penelitian yang mengkaitkannya dengan teori Van Hiele. Oleh karena itu, penelitian ini bertujuan untuk mengukur sejauhmana tingkat berpikir geometris dalam menyelesaikan soal lingkaran berdasarkan teori Van Hiele. Kami menggunakan metode kualitatif dengan melibatkan 21 siswa kelas VIII SMP Muhammadiyah Kampung Pisang. Data dikumpulkan berdasarkan hasil penyelesaian dan transkip wawancara. Data yang terkumpul di analisis dengan menggunakan pedoman rubrik penilaian, serta mengklasifikasi kemampuan geometris siswa kategori tinggi, kategori sedang, kategori rendah, dan kemudian diambil kesimpulan. Hasil penelitian ini menunjukkan bahwa siswa berkemampuan geometris tinggi, sedang dan rendah memberikan gambaran yang berbeda-beda dalam menyelesaikan masalah geometri berdasarkan teori Van Hiele. Hasil penelitian ini memberikan implikasi pada pengembangan wawasan terkait pentingnya berfikir geometris
CARA EFEKTIF MENYUSUN KARYA TULIS YANG SISTEMATIS BAGI MAHASISWA KESEHATAN
Authors: Masyfufah Lilis , Sutha Diah Wijayanti 
Published: June 2024

Penulisan tugas akhir berupa karya tulis ilmiah masih menjadi kewajiban mahasiswa perguruan tinggi untuk lulus dari pendidikan yang ditempuh, termasuk bagi mahasiswa Kesehatan. Pada jurusan Kesehatan, karya tulis yang disusun bersifat problem solving. Salah satu mata kuliah yang wajib ditempuh untuk medukung tugas akhir ini adalah Metodologi Kesehatan, namun masih dirasa belum cukup untuk membuat paham mahasiswa untuk menghasilkan karya akhir yang sistematis. Oleh karena itu, dilakukanlah pelatihan Cara Efektif Menyusun Karya Tulis yang Sistematis bagi Mahasiswa Kesehatan. Metode kegiatan dilakukan dengan cara pelatihan secara online, dengan maksud bisa mencakup peserta yang lebih banyak dan dapat diakses dari mana saja. Hasil dari kegiatan ini adalah peserta diberikan paparan terkait dengan cara pengecekan karya tulis sehingga sistematis sesuai dengan kaidah penulisan karya tulis ilmiah. Karya tulis untuk tugas akhir jurusan Kesehatan harus berawal dari adanya masalah yang kemudian dikaji dengan teori dan metode tertentu, sehingga bisa menghasilkan suatu kesimpulan dan memberikan solusi yang relevan untuk masalah tersebut. Kegiatan ini berlangsung dengan aktif partisipatif dari peserta karena dinilai penting untuk diberikan utamanya kepada mahasiswa Kesehatan tingkat akhir.
Kata Kunci: metode penelitian, pelatihan karya tulis ilmiah, pelatihan penulisan