bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experience of using immunomodulatory therapy in the complex treatment of mild community-acquired pneumonia and its long-term results
Authors: Kostinov M. P. , Gainitdinova V. V. , Kazharova S. V. , Vlasenko A. E. , Polishchuk V. B. , Allaberdina D. U. 
Published: April 2024

A decrease of nonspecific body resistance, an imbalance of local and systemic immunity and a free-radical oxidation abnormality substantially contribute to the pathogenesis of community-acquired pneumonia (CAP).Purpose: To study the efficiency of including immunomodulators into the comprehensive treatment of nonsevere community-acquired pneumonia and assess the long-term effects of the treatment conducted.Patients (n = 55) with non-severe CAP (41 (31-48) years old, with CRB-65 score of 0.15 (0-1)) are included in the study. Group 1 (control) received only standard CAP therapy; the other two groups received immunomodulators concurrently with the standard therapy: bacterial lysate (BL) for group 2 and azoximer bromide (AzB) for group 3. TNFα and IL-6 concentration was determined on the day of visit, on day 13 and day 60 of follow-up. During 2 years, the incidence of low respiratory tract infections (LRTI) was studied in the same patients with CAP in past (n = 55). All patients (n = 55) had clinical signs of non-severe community-acquired pneumonia. The overall duration of all symptoms was lower in immunomodulators groups as compared to the control group: 12 (11-13) days in BL group (p < 0.001) and 12 (11-12) days in AzB group (p < 0.001) with no statistically significant difference between intervention groups (p = 0.36). During treatment, TNFα and IL-6 concentration decreased on day 13 and day 60 in all patients; in patients who received immunomodulators, TNFα and IL-6 were reliably lower as compared to the control. Changes of TNFα and IL-6 concentration in the groups on day 60 of the study as compared to the baseline showed a decrease in BL group by 85 (-89 – -82) % and 86 (-90 – -85) % (p < 0.001; p = 0.001 and control); in AzB group by 82 (-86 – -80) % and 86 (-88 – -84) % (p = 0.002; p = 0.007 and control). Intensity of IL-6 concentration decrease on day 60 in BL and AzB groups did not differ (p = 0.72). Gender- and age-adjusted odds ratio for the development of low respiratory tract diseases (during 2 years after CAP) in AzB group was 0.15 (0.02-0.93) (p = 0.04) suggesting its protective effect. Inclusion of immunomodulators in basic treatment of non-severe community-acquired pneumonia reduces duration of symptoms and is associated with improvement of the proinflammatory cytokine profile. In 2 years of follow-up, long-term effects of the immunomodulatory therapy showed statistically significant lower incidence of low respiratory tract infections in AzB group only.
The role of <i>Pseudomonas aeruginosa</i> pneumonia in the development of cardiovascular events in patients with heart failure
Authors: Podzolkov V. I. , Tarzimanova A. I. , Ponomareva L. A. , Ivannikov A. A. , Chinova A. A. , Popova E. N. , Ponomarev A. B. , Morozova O. A. , Gladun L. G. , Isaeva A. Yu. 
Published: April 2024

Aim. To assess the contribution of Pseudomonas aeruginosa pneumonia to the development of cardiovascular events in patients with heart failure (HF).Material and methods. The study included 219 patients who were divided into a group of patients with pneumonia caused by P. aeruginosa (Group I) and a group of patients with pneumonia caused by S. aureus, S. pneumoniae (Group II). All patients underwent chest computed tomography (CT), blood tests, echocardiography, electrocardiography (ECG), 24-hour Holter ECG monitoring, pulse oximetry (SpO2), and Doppler ultrasound of the lower limb veins.Results. According to the study, cardiovascular events were more often observed in the group of patients with P. aeruginosa pneumonia as follows: death from cardiovascular events was registered in 11,4% of patients in group I and 0% of patients in group II (p=0,001); acute coronary syndrome — in 8,7 vs 0% (p=0,002), lower limb thrombosis — in 14 vs 1,9% (p=0,001). The occurrence of P. aeruginosa pneumonia in patients with HF increased the cardiovascular death risk by 8,8 times (95% confidence interval (CI): 1,2-65,7; p=0,005), acute coronary syndrome — in 8,0 times (95% CI: 1,1-60,2; p=0,014), lower limb thrombosis — in 9,6 times (95% CI: 1,3-71,2; p=0,004).Conclusion. Patients with HF and P. aeruginosa pneumonia are at greater risk of cardiovascular events than patients with pneumonia caused by S. pneumonia and S. aureus.
Verification of the presence of superabsorbent polymers (SAP) in fresh concrete: results of an interlaboratory study of RILEM TC 260-RSC
Authors: Wyrzykowski Mateusz , Schroefl Christof , Toropovs Nikolajs , Lura Pietro , Snoeck Didier , Bettencourt Ribeiro António , Kara De Maeijer Patricia , Moon Juhyuk , Assmann Alexander , Igarashi Shin-Ichi , Klemm Agnieszka , Almeida Fernando C. R. , Boshoff Billy , Erk Kendra A. , Falikman Vyatcheslav , Agostinho Livia Borba , Mechtcherine Viktor 
Published: April 2024

AbstractNew methods are proposed for the verification of the presence of superabsorbent polymers (SAP) in freshly mixed concrete and estimation of SAP quantity. The methods are in general based on flushing concrete with excess water. They allow separating the light, water-sorbed hydrogel particles from the mineral components in the fresh concrete and making these particles available for further tests. Two types of tests are proposed: Test 1 serves for a visual verification of the presence of SAP (qualitative test), while Test 2 enables quantifying the mass of the collected SAP as a proxy of their concentration in concrete (quantitative test). Different procedures are proposed for these two test methods and their performance is evaluated. The testing procedures were scrutinized in an interlaboratory study carried out by 14 participants from 12 countries. All participating groups detected the presence of SAP in the mix using the qualitative procedures (Test 1). Based on this outcome, we suggest that this method should be applied in the field. In contrast, while most participants obtained reasonably reliable results with the quantification procedure of Test 2, some participants reported large errors. Therefore, the quantification method needs to be further refined, starting from the experience gained in this interlaboratory study.
Problems of hyperacusis and misophonia occurring in patients with tinnitus
Authors: Raj-Koziak Danuta , Gos Elżbieta , Kutyba Justyna , Skarżyński Piotr H. , Skarżyński Henryk 
Published: April 2024

WprowadzenieNadwrażliwość słuchowa i mizofonia to rodzaje obniżonej tolerancji na dźwięk. Obie te dysfunkcje mają pewne cechy wspólne, jednak każda z nich ma swoją specyfikę. Szczególnie często występują w przebiegu szumów usznych, stanowiąc dodatkową dolegliwość dla pacjentów. Celem pracy jest określenie rodzaju i nasilenia problemów związanych z obniżoną tolerancją na dźwięki, tj. nadwrażliwością słuchową i mizofonią, zgłaszanych przez pacjentów z szumami usznymi.Materiał i metodyW badaniu wzięło udział 101 pacjentów (54 kobiety i 47 mężczyzn) z szumami usznymi, w wieku od 19 do 72 lat. Wszyscy zgłaszali dodatkowe problemy związane z obniżoną tolerancją na dźwięki. Badanie audiologiczne obejmowało: wywiad, wideootoskopię, audiometrię tonalną i impedancyjną oraz ocenę poziomu nieprzyjemnego słyszenia. Pacjenci wypełniali: <i>Kwestionariusz uciążliwości szumów usznych</i> (THI), <i>Wizualną skalę analogową</i> (VAS) oraz autorski <i>Kwestionariusz nadwrażliwości słuchowej</i> (KNS).WynikiProgi słyszenia wynosiły przeciętnie około 16–18 dB HL dla przewodnictwa powietrznego i około 10 dB HL dla przewodnictwa kostnego. Prawidłowe wynik tympanometrii stwierdzono
u 97% pacjentów. Przeciętny próg dyskomfortu wynosił około 72–76 dB HL. Stwierdzono korelację między uciążliwością szumów usznych a nadwrażliwością słuchową (<i>rho</i> = 0,31), natomiast brak było związku między uciążliwością szumów usznych a mizofonią (<i>rho</i> = 0,04).WnioskiNadwrażliwość słuchowa oraz mizofonia, będące rodzajem obniżonej tolerancji na dźwięki, często współwystępują z szumami usznymi. W praktyce klinicznej powinny być różnicowane
i wskazane jest, by ich diagnostyka i terapia były prowadzone przez wielodyscyplinarny zespół specjalistów.
Review of mobile apps for self-testing of hearing in Polish language
Authors: Pastucha Małgorzata , Kochanek Krzysztof , Piłka Edyta , Jędrzejczak Wiesław W. 
Published: April 2024

WstępDynamiczny rozwój technologii informacyjno-komunikacyjnych stanowi ogromny potencjał dla obszaru opieki zdrowotnej. Pozwala on na wdrażanie nowoczesnych rozwiązań, które mogą być pomocne w usprawnianiu usług związanych ze zdrowiem. Należą do nich m.in. aplikacje mobilne, których liczba wzrasta z każdym rokiem. Efektem tego jest szybki rozwój rynku aplikacji, a ich powszechna dostępność sprawia, że już teraz są wykorzystywane m.in. do wstępnej samooceny słuchu, a w przyszłości mogą wspomóc klasyczne badania przesiewowe wykonywane z użyciem specjalnych urządzeń. Celem pracy było zidentyfikowanie dostępnych aplikacji mobilnych w języku polskim umożliwiających wyznaczenie progu słyszenia.Materiał i metodyPrzeglądu dokonano z wykorzystaniem platformy Google Play Store. Do dalszej analizy włączono darmowe aplikacje w języku polskim służące do wyznaczania progu słyszenia.WynikiW wyniku wyszukiwania zidentyfikowano 5 aplikacji spełniających kryteria włączenia, czyli umożliwiających m.in. wykonanie audiometrii tonalnej (AT) w standardowym zakresie częstotliwości (do 8000 Hz). Dodatkowo aplikacja „Badanie słuchu e-audiologia.pl”
pozwala na wyznaczenie progu słyszenia także dla wyższych częstotliwości (10 000–18 000 Hz) oraz na sprawdzenie zrozumiałości mowy w szumie. Żadna ze znalezionych aplikacji nie zawiera funkcjonalności, która umożliwiałaby wykonanie tzw. audiometrii zabawowej, wykorzystywanej do badania słuchu małych dzieci.WnioskiNa rynku istnieje kilka aplikacji mobilnych, które mogą służyć do samooceny słuchu. Dużą lukę, zwłaszcza na rynku polskim, stanowi zupełny brak aplikacji mobilnych, dzięki którym możliwe byłoby wyznaczenie progu słyszenia u dzieci za pomocą tzw. audiometrii zabawowej.
Recensión Fuentes del Derecho Romano online
Authors: Murillo Villar Henar 
Published: April 2024

Recensión a la obra Fuentes del Derecho Romano online, Madrid, BOE, 2022. Selección y recopilación a cargo de Mª del Carmen López-Rendo Rodríguez y Mª José Azaustre Fernández.
El Volumen I está realizado por Mª del Carmen López-Rendo Rodríguez; el Volumen II por Mª José Azaustre Fernández y el Volumen III ha sido elaborado en coautoría por ambas.

Se trata de una recopilación de vínculos a diversos repositorios que albergan multitud de obras literarias y jurídicas de Derecho romano en todas sus etapas, digitalizadas online, así como del derecho bizantino; del derecho visigodo; del derecho histórico español, sin preterir las fuentes de la etapa codificadora y la legislación vigente, incluyéndose además obras de los más relevantes comentaristas a las diferentes fuentes.
Aplikasi serbuk daun mangrove (Rhizopora sp.) sebagai pengawet alami tali rami pada alat tangkap jaring ikan
Authors: Krisnafi Yaser , Sumartini Sumartini , Mardiah Ratu Sari 
Published: April 2024

Tali rami adalah bahan yang digunakan untuk membuat jaring pada alat tangkap. Sifat tali rami yang mudah busuk dan masa pakai yang singkat membuat tali ini kurang diminati oleh nelayan. Bahan pengawet digunakan untuk menambah usia pakai tali rami, salah satunya adalah daun mangrove. Penelitian ini bertujuan untuk menentukan pengaruh aplikasi serbuk daun mangrove Rhizophora sp. sebagai pengawet tali rami berdasarkan parameter kemuluran benang dan kuat putus. Daun mangrove Rhizophora sp. yang digunakan jenis daun muda dengan warna hijau tidak pekat. Serbuk daun mangrove Rhizophora sp. dianalisis proksimat dan fitokimia. Pengawetan tali rami terdiri atas perlakuan tanpa perendaman serbuk daun Rhizophora sp. (kontrol) dan perendaman 0,3; 0,5; 0,7; dan 0,9 kg/L. Hasil penelitian menunjukkan bahwa serbuk daun mangrove Rhizophora sp. memiliki kadar air 6,31±0,06%; lemak 0,66±0,05%; abu 8,28±0,10%; protein 8,74±0,04%; serat kasar 15,25±0,05%; dan karbohidrat 65,76±0,05%. Serbuk daun mangrove Rhizophora sp. terdeteksi mengandung senyawa fenol, alkaloid, flavonoid, tanin, dan saponin. Perbedaan konsentrasi perendaman serbuk daun mengrove dapat memengaruhi (p<0,05) kuat putus basah , namun pada parameter lainnya (kadar air, kemuluran benang basah-kering), kuat putus kering dengan pemberian serbuk daun mangrove pada rentang konsentrasi 0,3-0,9 kg/L tidak berpengaruh signifikan.
Clinical profile of patients with acute ischaemic stroke undergoing thrombolysis in a tertiary hospital- A retrospective observational study
Authors: Balagopal Krishnan , Mathew Smita  Raechel , Koshy Riya Ann 
Published: April 2024

Acute ischaemic stroke is one of the most important causes of morbidity and mortality in the Indian subcontinent. Intravenous thrombolysis has revolutionized the treatment of acute stroke and has shown good evidence of its efficacy in most patients. The primary objectives of the study were to study the clinical and demographic profile of stroke patients undergoing intravenous thrombolysis and to determine their functional outcome after three months. The study was done by retrospective chart analysis of all patients with acute stroke in Neurology department undergoing intravenous thrombolysis over a one year period. Primary outcome was measured by assessing the Modified Rankin Scale after three months.A total of 56 patients underwent intravenous thrombolysis in the study period of which 68 percent were males. The average age of the study population was 62.4 years. The most common co- morbidities noted were hypertension followed by dyslipidemia, type 2 diabetes mellitus, coronary artery disease and chronic kidney disease among others. The average duration of the window period and door to needle time were 148.4 minutes and 66.3 minutes respectively. Intracranial haemorrhage was noted in seven patients (12.5%) of which six expired. Favourable outcome defined by MRS score of 0-2 was achieved in almost 68% of all patients undergoing thrombolysis.Intravenous thrombolysis is an effective mode of treatment for acute stroke with favourable outcomes obtained in the majority of patients undergoing the same.
Investigation of Anticancer Properties of Cinnamon Phytochemicals on Protein expression in Glioblastoma Multiforme Cell Lines (U87-MG)
Authors: M Prabha , George Tina Mary , Patil Mukta S , Sakshi Soumya , Shifa  
Published: April 2024

Natural products are appealing as anticancer agents because of their low toxicity profiles. Cinnamon is a naturally occurring component with a variety of pharmacological properties, including anti-oxidant, anti-microbial, and anti-cancer properties for cancer cell apoptosis. Therefore, the current studies were performed to investigate Anticancer Properties of Cinnamon Phytochemicals on Protein expression in Glioblastoma Multiforme Cell Lines (U87-MG) since the proteins are directly involved in cell survival and function.Hot and cold extraction for Cinnamon performed from Cinnamon verum followed by phytochemicals tests. The Glioblastoma Multiforme Cell Lines U87 was subjected to cell viability by MTT Assay with Addition of cinnamon extract. The protein content was determined by spectrometric assay and its expression was investigated by SDS PAGE.The aqueous Cinnamon extract found to be positive for Alkaloids, Tannins, Saponins, Flavonoids, Terpenoids (only for Hot extract), Phenols and Reducing sugars (only for Cold extract). The cell viability at cinnamon extract concentration of 0.051 mg/100μl is shown to be highest and cell death at maximum cinnamon extract concentration of 1.65 mg/100μl is highest. Further these phytochemicals together showed less protein content on cultured U-87 cells and displayed lower protein expression in gel band pattern when compared to their control. The Cinnamon extract phytochemicals showed significant anticancer properties for reduced U87 cell viability with IC50 0.729. Thus positive phytochemicals result has shown to play an important role in inhibiting cancer properties.by showing less protein content and its expression for cinnamon phytochemicals treated U87 cell lines.
Reaffirming the Queer Traumatized Self through Home: An Analysis of the Potential of Traumascapes in John Elizabeth Stintzi’s <em>Vanishing Monuments</em> (2021).
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Authors: Corpus Navalón-Guzmán  
Published: April 2024

This article examines John Elizabeth Stintzi’s novel Vanishing Monuments (2021) applying the views of trauma, queer theory, and the potential discussions around the notion of place. The main issue in Vanishing Monuments is how returning home implies grappling with a non-linear account of haunted memories related to identity and trauma. Drawing on Maria Tumarkin’s concept of traumascapes and connecting it to Cvetkovich’s notion of “queer trauma,” this article aims at disclosing the potentialities that physical spaces can have for the traumatized queer subject. Firstly, this paper’s analysis will draw a connection between trauma and place to examine the function that the protagonist’s house has in the enactment of their trauma. Secondly, I will explore how the main character’s trauma is embodied in the narrative through a link between the concept of traumascapes and Ann Cvetkovich’s notion of queer trauma. This article concludes by evaluating the role that traumascapes might have for the queer subject to productively respond to trauma outside pathological boundaries.
Anti-tax evasion rules and the Autonomous Taxation of companies in Portugal
Authors: Rodrigues Carlos , Campina Ana 
Published: April 2024

States, in their tax systems, create anti-tax evasion rules to try to eliminate the possibility of taxpayers engaging in behavior that harms the state in collecting the taxes that each citizen or company owes. Anti-tax evasion rules also aim to ensure that everyone contributes to public spending according to their real ability to pay, thus respecting the principle of equal contribution based on real and effective economic and financial capacity. Aware that there are companies that carry out harmful acts and thus reduce their economic and financial capacity to try to reduce their tax burden in terms of corporate income tax, the Portuguese legislator introduced autonomous taxation in corporate income tax, in the corporate income tax code, to try to eliminate belligerent behavior on the part of companies. Using the statistical data from the Autoridade Tributária e Aduaneira, and based on statistics from the tax and customs authority, the study demonstrates the financial burden on companies that bear this type of taxation and compare it with the "Corporate Income Tax" charged annually by the State.
Keywords: Anti-abuse rules; anti-avoidance rules; autonomous taxation; corporate tax; corporate taxation
Utilizing Baidu index data to understand the spatio-temporal characteristics of public interest towards gender discrimination
Authors: Tan Qinyi , Wang Meijie , He Fang , Chen Xiaolu , Teng Luyan , Liu Haiou 
Published: April 2024

Gender equality has always been a hot topic of global concern. This study aims to understand the temporal and spatial characteristics of public interest towards gender discrimination in China, providing information support for eliminating gender discrimination and promoting social equity in China, to achieve the United Nations Sustainable Development Goal 5. It uses the Baidu Index as the research tool, selecting gender discrimination as the keyword, taking July 1, 2013, to October 13, 2022, as the research interval to analyze the trend research, demand map, and population portrait of gender discrimination. It is found that the search trend of gender discrimination is slowly rising year by year, from the overall trend of personal computers (PC) and mobile. The peak appears periodically during the Spring Festival and summer vacation each year; "Gender discrimination" has a significant peak in early March 2017 and mid-June 2022. Additionally, the public also shows great concern for discrimination and racial discrimination. Most netizens who pay attention to gender discrimination come from East China.
Keywords: Baidu index; gender discrimination; public interest; search engine; social concern
Achieving SVR in patients with hepatitis C-related HCC is associated with an improvement in overall survival: real word data
Authors: Guerra Veloz María Fernanda , Shah Sital , Lok James , Mohamed Almuthana , Cannon Mary , Ross Paul J , Carey Ivana , Agarwal Kosh 
Published: April 2024

Aims: The optimal timing for DAA therapy initiation in patients with chronic hepatitis C (CHC) and HCC is still debated. The aim of our study was to provide real-world data on virological response and overall survival in patients with hepatitis C-related HCC.
Methods: Retrospectively, we included patients with HCV-related HCC between 2015 and 2020. The primary outcome was to compare the SVR rate in the patients with active or historical HCC who were treated with DAA therapy. The secondary outcome was to measure the overall survival of those patients.
Results: 98 patients were included, and the majority were cirrhotic with compensated liver disease. 71.4% received DAA therapy at the time of initial HCC diagnosis and 11.2% received HCV treatment at the time of HCC recurrence (Active HCC cohort). 17.3% had previously received HCC treatment, but there was no evidence of recurrence at the time of DAA (Historical HCC Cohort). The SVR rate was 81.6%, but decreased to 75.7% in patients with active HCC. The presence of active HCC and the number of HCC nodules were the only factors associated with not achieving SVR in the multivariate analysis. The median survival was higher in those who achieved SVR. Active HCC and failure to achieve SVR were the main factors associated with mortality.
Conclusions: Treating hepatitis C in patients with HCC is feasible with significant rates of SVR, even if SVR rates decrease in patients with active HCC and these patients require more than one DAA therapy. Failure to achieve SVR is one of the main factors associated with mortality.
UJI EFEKTIVITAS ANTIBAKTERI EKSTRAK DAUN RAMANIA (Bouea Macrophylla Griff) TERHADAP PERTUMBUHAN BAKTERI Streptococcus mitis
Authors: Aini Lisa Shofa’ Nur , Erlita Isyana , Aspriyanto Didit 
Published: April 2024

Background: The presence of cavities causes bacterial invasion and spread of infection to the pulp tissue. If left untreated, infection will lead to pulpal necrosis. Root canal treatment can prevent caries from developing into necrosis. The success of treatment is influenced by the preparation and irrigation stages. One of the bacteria that survived after the treatment was Streptococcus mitis. The irrigation solution used in treatment is a 2% chlorhexidine gluconate. Ethanol extract from Ramania leaves is known to contain flavonoids, phenols, alkaloids, steroids and terpenoids which proven to have antibacterial activity. Objective: To analyze the antibacterial effectiveness of Ramania leaf extract concentrations of 10%, 15%, 20%, 25% and 30% against the growth of Streptococcus mitis . Methods: The research conducted was a true experimental study with 6 treatment groups and 4 repetitions. This study used broth and agar dilution methods to determine the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) of ramania leaf extract against Streptococcus mitis. Results: The MIC was shown by 10% concentration with a decrease in absorbance value of 1.726. The MBC in this study were not found because there was still bacterial growth in the concentrations of 10%, 15%, 20%, 25% and 30%. Conclusion: Ramania leaf extract concentrations of 10%, 15%, 20%, 25% and 30% can inhibit the growth of Streptococcus mitis with MIC value at a concentration of 10%. The MBC value was not found because the extract had not been able to kill the growth of Streptococcus mitis. Keywords : MBC, MIC, Ramania Leaf Extract, Streptococcus mitis