bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gastric cancer actionable genomic alterations across diverse populations worldwide and pharmacogenomics strategies based on precision oncology
Authors: Echeverría-Garcés Gabriela , Ramos-Medina María José , Vargas Rodrigo , Cabrera-Andrade Alejandro , Altamirano-Colina Adriana , Freire María Paula , Montalvo-Guerrero Juliana , Rivera-Orellana Sebastián , Echeverría-Espinoza Paulina , Quiñones Luis A. , López-Cortés Andrés 
Published: May 2024

Introduction: Gastric cancer is one of the most prevalent types of cancer worldwide. The World Health Organization (WHO), the International Agency for Research on Cancer (IARC), and the Global Cancer Statistics (GLOBOCAN) reported an age standardized global incidence rate of 9.2 per 100,000 individuals for gastric cancer in 2022, with a mortality rate of 6.1. Despite considerable progress in precision oncology through the efforts of international consortia, understanding the genomic features and their influence on the effectiveness of anti-cancer treatments across diverse ethnic groups remains essential.Methods: Our study aimed to address this need by conducting integrated in silico analyses to identify actionable genomic alterations in gastric cancer driver genes, assess their impact using deleteriousness scores, and determine allele frequencies across nine global populations: European Finnish, European non-Finnish, Latino, East Asian, South Asian, African, Middle Eastern, Ashkenazi Jewish, and Amish. Furthermore, our goal was to prioritize targeted therapeutic strategies based on pharmacogenomics clinical guidelines, in silico drug prescriptions, and clinical trial data.Results: Our comprehensive analysis examined 275,634 variants within 60 gastric cancer driver genes from 730,947 exome sequences and 76,215 whole-genome sequences from unrelated individuals, identifying 13,542 annotated and predicted oncogenic variants. We prioritized the most prevalent and deleterious oncogenic variants for subsequent pharmacogenomics testing. Additionally, we discovered actionable genomic alterations in the ARID1A, ATM, BCOR, ERBB2, ERBB3, CDKN2A, KIT, PIK3CA, PTEN, NTRK3, TP53, and CDKN2A genes that could enhance the efficacy of anti-cancer therapies, as suggested by in silico drug prescription analyses, reviews of current pharmacogenomics clinical guidelines, and evaluations of phase III and IV clinical trials targeting gastric cancer driver proteins.Discussion: These findings underline the urgency of consolidating efforts to devise effective prevention measures, invest in genomic profiling for underrepresented populations, and ensure the inclusion of ethnic minorities in future clinical trials and cancer research in developed countries.
Insights into discrepancies in professional identities and role models in undergraduate medical education in the context of affective burden
Authors: Erschens Rebecca , Skrypski Isabelle , Festl-Wietek Teresa , Herrmann-Werner Anne , Adam Sophia Helen , Schröpel Carla , Nikendei Christoph , Zipfel Stephan , Junne Florian 
Published: May 2024

IntroductionInternational evidence strongly suggests that medical students are at high risk of mental health problems. This distress, which can be mediated by a variety of individual, interpersonal and contextual factors within the curriculum, can be mitigated by effective coping strategies and interventions. Central to this discourse is the recognition that the challenges of professional identity formation can contribute significantly to medical students' distress. The focus of our study is therefore to examine discrepancies in professional identities and role models in undergraduate medical education in relation to affective burden.MethodsMedical students at different stages of university education and high school graduates intending to study medicine were surveyed in a cross-sectional study. The study employed Osgood and Hofstätter's polarity profile to evaluate the self-image of participants, the image of an ideal and real physician, and their correlation with depression (PHQ-9) and anxiety (GAD-7).ResultsOut of the 1535 students recruited, 1169 (76.2%) participated in the study. Students rated their self-image as somewhere between a more critical real image of physicians and a more positive ideal image. Medical students at all training levels consistently rated the ideal image as remaining constant. Significant correlations were found between the professional role models of medical students and affective symptoms, particularly for the discrepancy between the ideal image of a physician and their self-image. Furthermore, 17% and nearly 15% reported significant symptoms of depression and anxiety, respectively.DiscussionOur study adds to the growing body of knowledge on professional identity formation in medicine and socialisation in the medical environment. The study highlights the importance of discrepancies between self-image and ideal image in the experience of depressive and anxiety symptoms. Primary prevention-oriented approaches should incorporate these findings to promote reflective competence in relation to professional role models and strengthen the resilience of upcoming physicians in medical training.
An enhancement of the Genium™ microprocessor-controlled knee improves safety and different aspects of the perceived prosthetic experience for unilateral and bilateral users
Authors: Klenow Tyler D. , Lundstrom Russell L. , Morris Arri , Patterson Stan , Simpson Chad , Trejo Ernesto G. , Kannenberg Andreas 
Published: May 2024

IntroductionBilateral microprocessor-controlled prosthetic knee (MPK) users have unique needs in traversing environmental barriers compared to unilateral users. An enhancement to the Genium™/Genium X3™ MPK which included an updated ruleset, hydraulics, and new bilateral parameter presets was made to improve safety while stumbling and the smoothness of gait for all users while also improving the experience of bilateral users. The purpose of the study was to evaluate the effectiveness of the enhancements in a sample with unilateral and bilateral amputation.MethodsA convenience sample of MPK users was recruited from two sites in the USA in two phases. Assessments included the L-Test of Functional Mobility, Activity-specific Balance Confidence Scale, Prosthetic Limb User Survey of Mobility, a study-specific questionnaire, and the Comparative Activities of Daily Living (ADL) Questionnaire. Statistical significance of extracted data was tested with the Wilcoxon Rank-Sum Test for independent data and Wilcoxon Signed-Rank for paired data with an a priori significance level of p &lt; 0.05. Unilateral subjects were age-matched to the group of bilateral subjects for between-groups and within-groups analyses.ResultsTwenty-six subjects (n = 26) were enrolled. Stumble frequency reduced 85% from 16.0 ± 39.7 to 2.4 ± 2.3 (p = 0.008) between baseline and final assessment overall. The bilateral group reported 50% (p = 0.009) and 57% (p = 0.009) greater relative improvement in patient-reported ease and safety, respectively, of completing ADLs compared to the unilateral group. The unilateral group reported residual limb pain and low back pain reduced from 2.3 to 1.4 (p = 0.020) and 3.8 to 1.8 (p = 0.027), respectively, whereas the bilateral group did not.DiscussionSubstantial reductions in stumbles, residual limb pain, and back pain were shown overall. These reductions were driven by the unilateral group who also showed improvements in comfort, exertion, and concentration while walking. The enhancements to the knee likely reduced some gait asymmetry for unilateral users. Improvements in patient-reported ease and safety of completing ADLs were shown overall and were driven by the bilateral group. This study shows further improvement in patient experience is achievable through innovation in MPK technology even for patients who appear to be functioning well.
Reproducibility of freehand vs. foam cast as well as the intrarater reliability of foam cast ultrasound scans assessing the muscle architecture and tissue organization of the gastrocnemius medialis and vastus lateralis muscles
Authors: Lesinski Melanie , Bashford Gregory , Markov Adrian , Risch Lucie , Cassel Michael 
Published: May 2024

BackgroundThis study compares the reproducibility of freehand (FH) vs. foam cast (FC) scans and investigates the intrarater reliability of the ultrasound FC muscle architecture and tissue organization measurements of the gastrocnemius medialis (GM) and vastus lateralis (VL) muscles with fixed and repositioning FC scans.MethodsThirteen young adults (22 ± 3 years) underwent repeated sagittal B-mode ultrasound measurements of GM and VL. FH, FC, and repositioned FC scans were conducted. Muscle architecture measurements included muscle thickness (MT), pennation angle (PA), and fascicle length (FL). Spatial frequency analysis assessed muscle tissue organization.ResultsMT decreased from 2.1 to 1.8 cm in GM and from 2.4 to 2.2 cm in VL with the FC compared with the FH. Reproducibility between the FH and the FC showed poor to good intraclass correlation coefficients (ICCs) for MT (0.46–0.77) and PA (0.09–0.86) as well as poor to moderate ICCs for FL (0.41), with very low to moderate test–retest variability (TRV) (4%–18%). Tissue organization indicated low to good ICCs (0.21–0.80) with low to moderate TRV (4%–19.5%). The re-scanning results of fixed FC indicated excellent ICCs for MT (0.95–0.996), good for PA (0.77–0.90), and moderate for FL (0.73–0.76), with low TRV (5%–10%) for both muscles. Tissue organization displayed moderate to good ICCs (0.61–0.87) with very low to low TRV (4%–9%). For repositioned FC scans in GM and VL, MT showed good to excellent ICCs (0.86–0.98) with very low to low TRV (2%–8%). PA and FL demonstrated moderate to good ICCs (0.57–0.75), with very low to moderate TRV (2%–13%). Tissue organization revealed ICCs ranging from poor to good (0.13–0.87) for both muscles, with low to moderate TRV (5%–18%).ConclusionThe FC systematically reduced MT by 2–3 mm. Furthermore, reproducibility revealed low ICCs and high data variability for several muscle architecture and tissue organization parameters. Thus, switching methods within a single study is not recommended. Nevertheless, FC ultrasound scans demonstrated excellent intrarater reliability for assessing MT. In the case of fixed FC scans particularly, moderate to excellent ICCs were observed for all muscle architecture and tissue organization parameters, accompanied by very low to low variability. Therefore, FC scans are recommended for investigating acute effects on muscle architecture and tissue organization when the FC remains on the leg throughout the period of measurements.
Sensory profiles of Robusta coffee (Coffea canephora) genetic resources from the Democratic Republic of the Congo
Authors: Bollen Robrecht , Verleysen Lauren , Katshela Benjamin Ntumba , Kambale Jean-Léon , Ebele Tshimi , Ruttink Tom , Vandelook Filip , Honnay Olivier , Stoffelen Piet 
Published: May 2024

IntroductionThe genetic diversity of Robusta coffee (Coffea canephora), a cornerstone in the global coffee industry, remains not fully explored, leading to a significant gap in our understanding of its sensory intricacies. Our study evaluated the sensory quality potential of the Robusta cultivars from the INERA Coffee Collection in Yangambi (the Democratic Republic of the Congo), the local wild diversity, and their hybrids.MethodsWe evaluated the sensory attributes of 70 genotypes representing the genetic structure of the coffee collection. Of those 70, 22 genotypes were evaluated for two consecutive years to assess the consistency of the sensory quality. Standard coffee cupping with the Fine Robusta Standards and Protocols was enhanced through sensory descriptors from the Coffee Taster’s Flavor Wheel. Each genotype’s sensory profile was constructed based on the Total cupping score and the frequency of reported sensory descriptors. The Total cupping score ranged from 75.75 to 84.75, with a substantial variation in sensory profiles, even within a genetic cluster.Results and discussionNutty/Cocoa was the most frequently reported descriptor class. The sensory profile ideotype exhibits a high frequency of Fruity, Sweet, and Sour/Fermented descriptors and a low frequency of Green/Vegetative, Other, and Roasted descriptors. Evidence suggests that the sensory profile of a genotype is consistent over two harvest years. Genotypes with promising and unique sensory profiles were discovered within the cultivars and the wild – cultivar hybrids. The genetic diversity of wild and cultivated Robusta in the Democratic Republic of the Congo could play an essential role in understanding and improving its sensory quality.
Spatio-temporal dynamics and drivers of highly pathogenic avian influenza H5N1 in Chile
Authors: Azat Claudio , Alvarado-Rybak Mario , Aguilera José F. , Benavides Julio A. 
Published: May 2024

IntroductionHighly pathogenic avian influenza A H5N1 clade 2.3.4.4b (hereafter H5N1) is causing vast impacts on biodiversity and poultry around the globe. In Chile, lethal H5N1 cases have been reported in a wide range of wild bird species, marine mammals, backyard and industrial poultry, and humans. This study describes the spatio-temporal patterns of the current epizootic of H5N1 in Chile and test drivers that could be associated with outbreak occurrence.MethodsWe used H5N1 cases reported by the Chilean National Animal Health Authority from 5 December 2022 to 5 April 2023. These included wild bird cases confirmed through an avian influenza-specific real-time reverse transcription PCR assay (RT-qPCR), obtained from passive and active surveillance. Data were analyzed to detect the presence of H5N1 clusters under space–time permutation probability modeling, the association of H5N1 with distance and days since the first outbreak through linear regression, and the correlation of H5N1 presence with a number of ecological and anthropogenic variables using general linear modeling.ResultsFrom 445 H5N1 identified outbreaks involving 613 individual cases in wild birds, a consistent wave-like spread of H5N1 from north to south was identified, which may help predict hotspots of outbreak risk. For instance, seven statistically significant clusters were identified in central and northern Chile, where poultry production and wildlife mortality are concentrated. The presence of outbreaks was correlated with landscape-scale variables, notably temperature range, bird richness, and human footprint.DiscussionIn less than a year, H5N1 has been associated with the unusual mortality of &gt;100,000 individuals of wild animals in Chile, mainly coastal birds and marine mammals. It is urgent that scientists, the poultry sector, local communities, and national health authorities co-design and implement science-based measures from a One Health perspective to avoid further H5N1 spillover from wildlife to domestic animals and humans, including rapid removal and proper disposal of wild dead animals and the closure of public areas (e.g., beaches) reporting high wildlife mortalities.
FACTORS AFFECTING ECONOMIC GROWTH OF THE SOUTHWEST KEY ECONOMIC REGION
Authors: Trung Nguyễn Hoàng , Hải Nguyễn Chí 
Published: May 2024

Nghiên cứu này hướng đến việc tìm hiểu các yếu tố tác động đến tăng trưởng kinh tế của vùng kinh tế trọng điểm Tây Nam Bộ. Nhóm tác giả nghiên cứu dựa trên bộ dữ liệu của 04 tỉnh, thành phố thuộc vùng trong giai đoạn 2005 - 2022, thông qua các phương pháp ước lượng dữ liệu bảng như hồi quy gộp OLS, tác động cố định (FEM), tác động ngẫu nhiên (REM). Sau khi tiến hành kiểm định và so sánh các mô hình này, REM được đánh giá là tối ưu nhất. Kết quả nghiên cứu cho thấy trong 6 yếu tố đưa vào phân tích bao gồm Lao động, Vốn đầu tư, Chi tiêu công, Giáo dục, Đầu tư trực tiếp nước ngoài và Tỷ lệ thất nghiệp, chỉ có chi tiêu công và đầu tư trực tiếp nước ngoài có tác động đến tăng trưởng kinh tế của vùng. Phát hiện này là cơ sở cho các tỉnh, thành thuộc vùng kinh tế trọng điểm tập trung cải thiện các chính sách liên quan đến sử dụng vốn đầu tư, thương mại quốc tế và thu hút đầu tư trực tiếp nước ngoài; nâng cao chất lượng lao động.
PHƯƠNG TRÌNH m-HESSIAN PHỨC CÓ TRỌNG
Authors: Phú Nguyễn Văn 
Published: May 2024

Giải phương trình m-Hessian là bài toán quan trọng trong lý thuyết về các hàm m-điều hòa dưới. Gần đây, nhiều tác giả quan tâm giải phương trình m-Hessian có trọng khi là một hàm đơn điệu không giảm theo biến thứ nhất và là độ đo triệt tiêu trên các tập m-cực. Trong bài báo này, chúng tôi nghiên cứu bài toán giải phương trình m-Hessian có trọng ở trên mà không cần giả thiết đơn điệu của hàm theo biến thứ nhất. Để đạt được kết quả trên, chúng tôi áp dụng Định lý điểm bất động Schauder bằng cách tạo ra một tập lồi, compact thích hợp và xây dựng một ánh xạ liên tục từ tập lồi compact được đề cập ở trên vào chính nó. Kỹ thuật để giải phương trình m-Hessian có trọng trong trường hợp không cần giả thiết hàm đơn điệu theo biến thứ nhất là rất khác biệt với các kĩ thuật được dùng trong trường hợp có giả thiết hàm đơn điệu theo biến thứ nhất. Chúng tôi cũng giải phương trình m-Hessian có trọng ở trên trong trường hợp độ đo bị chặn bởi một hàm thích hợp của m-dung lượng và đưa ra một ví dụ về độ đo thỏa mãn giả thiết đó.
SỰ TỒN TẠI VÀ DUY NHẤT NGHIỆM YẾU CỦA HỆ NAVIER-STOKES NGẪU NHIÊN CẢI BIÊN TOÀN CỤC BA CHIỀU TRONG MIỀN KHÔNG BỊ CHẶN
Authors: Hằng Hồ Thị , Nguyễn Phạm Trí 
Published: May 2024

Năm 2006, Caraballo, Real và Kloeden đã đề xuất một alpha-mô hình ba chiều của hệ Navier-Stokes trong đó số hạng phi tuyến bao gồm một nhân tử chặt cụt dựa trên chuẩn của gradient của nghiệm trong toàn miền. Các tác giả gọi hệ này là hệ phương trình Navier-Stokes cải biên toàn cục ba chiều. Các phương trình đạo hàm riêng ngẫu nhiên là một công cụ đắc lực để hiểu và nghiên cứu về mặt toán học của lý thuyết thủy động lực học và sự chuyển động hỗn loạn của chất lỏng. Để mô hình hóa chất lỏng hỗn loạn, các nhà toán học thường sử dụng các phương trình ngẫu nhiên thu được từ việc thêm một số hạng nhiễu vào phương trình động lực học của chất lỏng. Trong bài báo này, chúng tôi nghiên cứu hệ Navier-Stokes ngẫu nhiên cải biên toàn cục ba chiều với nhiễu cộng tính trong miền không bị chặn thỏa mãn bất đẳng thức Poincaré. Bởi quá trình Ornstein-Uhlenbeck, chúng tôi chuyển hệ ngẫu nhiên thành hệ tất định với các tham số ngẫu nhiên. Sau đó, chúng tôi chứng minh sự tồn tại và duy nhất nghiệm yếu của hệ theo phương pháp Galerkin.
ZALO MINI APP - ĐOÀN HỘI TRƯỜNG ĐẠI HỌC QUỐC TẾ: KẾT NỐI THÔNG TIN HIỆU QUẢ DÀNH CHO ĐOÀN VIÊN VÀ THANH NIÊN
Authors: Nguyên Lê Nguyễn Bình , Anh Đặng Nguyễn Nam , Khang Nguyễn Phúc , Tân Lê Duy , Anh Đào Kim , Mai Lê Thị Quỳnh , Quang Nguyễn Đăng 
Published: May 2024

Trong thời đại hiện nay, việc truyền đạt thông tin từ nhà trường tới sinh viên vẫn là một thách thức đối với nhiều cơ sở giáo dục. Nhận thấy điều này, mục tiêu của hệ thống đề xuất là cung cấp cho sinh viên một phương tiện tiếp cận thông tin từ nhà trường một cách nhanh chóng và tiện lợi, nhằm giải quyết vấn đề hạn chế này. Bằng cách áp dụng công nghệ Zalo Mini App, hệ thống được phát triển nhằm tối ưu hóa thời gian và tài nguyên của cả nhà trường và sinh viên. Chính vì sự tiện lợi của nền tảng này, Đoàn Thanh niên Trường Đại học Quốc tế - Đại học Quốc gia Hồ Chí Minh nhận thấy các tiềm năng của nền tảng này và đề xuất một ứng dụng kết nối thông tin hiệu quả với tên gọi IU Youth Mini App. Ứng dụng sử dụng công nghệ React để tự động cập nhật thông tin từ trang web trường và cung cấp trực tiếp các thông báo và sự kiện cho người dùng trên Zalo. Kết quả là các thông tin được cập nhật đầy đủ và chính xác từ phía nhà trường, đồng thời hỗ trợ sinh viên truy cập các thông tin quan trọng khác như bảng điểm. Qua đó, hệ thống đã đạt được mục tiêu ban đầu của mình và mang lại lợi ích đáng kể cho cả cộng đồng sinh viên và nhà trường.
The deposition and the optical characteristics of Cu-based metal halide Cs3Cu2I5 thin film via mist deposition
Authors: Watanabe Keisuke , Nishinaka Hiroyuki , Nishioka Yuuya , Imai Kousuke , Kanegae Kazutaka , Yoshimoto Masahiro 
Published: May 2024

Abstract
Cu-based metal halides, such as Cs3Cu2I5, are promising materials for LEDs, photodetectors, and scintillators because of their excellent optical properties, nontoxicity, and high air stability. In this study, we demonstrated the deposition of high-coverage Cs3Cu2I5 thin films using solution-based mist deposition. By adjusting the substrate temperature appropriately, continuous Cs3Cu2I5 thin films were formed. The Cs3Cu2I5 thin films exhibited blue emission under ultraviolet irradiation, with a large Stokes shift of 1.40 eV. Furthermore, they exhibited a high photoluminescence quantum yield of over 80%.
Do cognitive abilities reduce eyewitness susceptibility to the misinformation effect? A systematic review
Authors: Brassil Maryanne , O’Mahony Cian , Greene Ciara M. 
Published: May 2024

AbstractThe fact that memories can be distorted by post-event misinformation has cast considerable doubt over the dependability of eyewitness evidence in legal contexts. However, despite its adverse practical implications, the misinformation effect is likely an unavoidable distortion stemming from the reconstructive nature of episodic memory. Certain cognitive abilities have been reported to offer protection against misinformation, suggesting that mechanisms aside from episodic memory may also be underpinning this type of memory distortion. The purpose of this review was to collate findings of associations between eyewitness misinformation susceptibility and individual differences in cognitive ability in adults aged 18 and over. Nine studies met the eligibility criteria for this review, including 23 distinct associations. Using a narrative synthesis, three categories of cognitive ability were identified as influencing susceptibility to misinformation: general intelligence and reasoning, perceptual abilities, and memory abilities. Across almost all categories, higher levels of ability were associated with reduced susceptibility to misinformation. While there is no indication that any one trait provides total immunity to the misinformation effect, there is a reasonable amount of evidence to suggest that several cognitive abilities create variance in individual levels of susceptibility. Future research should investigate not only if but how these cognitive abilities protect against misinformation distortions, for example, by contributing to more detailed encoding of the memory, enhancing discrepancy detection in the face of post-event misinformation, or improving source-monitoring during an eyewitness memory test.