bluuebunny/crossref_metadata_2025_split huggingface dataset:
Customer‐facing supply chain practices—The impact of demand and distribution management on supply chain success
Authors: Rexhausen Daniel , Pibernik Richard , Kaiser Gernot 
Published: February 2012

AbstractTraditionally, distribution has been viewed as the key (physical) link between a company's internal supply chain activities and its customers. More recently, demand management has emerged as a new dimension at the customer interface. Although it has become increasing popular in industry, it has not yet been analyzed in depth with respect to its impact on supply chain performance. Both distribution management and demand management entail customer‐facing processes and practices and that are interrelated and (may) jointly determine supply chain performance. In this paper we seek to extend the stream of research in supply chain management by systematically investigating the impact of customer‐facing supply chain practices on supply chain performance. Specifically, the paper examines the relative impact of relevant practices associated with demand and distribution management. To this end, we collected data from 116 multi‐national companies based in Europe and analyzed it using structural equation modeling techniques. Our results suggest that (i) high demand management performance has a substantial positive impact on the overall supply chain performance, (ii) this effect is stronger than that of distribution management performance, and (iii) there is no evidence that demand management might be an enabler for effective distribution management. Among the individual practices that constitute demand and distribution management, adherence to the demand and distribution management processes and demand segmentation emerged as the strongest performance levers. Based upon additional in‐depth interviews conducted with selected companies from our sample, we shed light on some of the most important findings that emerged from our survey analysis.
Explaining the organizational and contractual context of subway construction disasters in China: The case of Hangzhou
Authors: Ma Yongchi , de Jong Martin , Koppenjan Joop , Xi Bao , Mu Rui 
Published: February 2012

AbstractChina has seen a number of serious infrastructure construction accidents in recent years. The focus of this paper will be on urban rail. Much has been written about the technical and circumstantial causes for these accidents, but relatively little about the organizational framework and contractual arrangements which constitute the context within which safety measures fail to be monitored and enforced effectively during such construction projects. This article aims to show how existing contractual incentives provide incentives for various involved parties which lead them to make decisions where safety is sacrificed to the benefit of other values. By regarding the contractual arrangements as the outcome of a power game between principal, agents and sub-agents, the social mechanisms that evoke strategic behavior among key players are proposed to explain the context in which operational choices are made. The case of the Hangzhou subway construction disaster, which has been the most dramatic instance in China to date, is used to illustrate the mechanisms we propose in our theoretical framework.
Childhood consumption of fruit and vegetables across England: a study of 2306 6–7-year-olds in 2007
Authors: Hughes Rebecca J. , Edwards Kimberley L. , Clarke Graham P. , Evans Charlotte E. L. , Cade Janet E. , Ransley Joan K. 
Published: February 2012

The School Fruit and Vegetable Scheme (SFVS) provides children in government-run schools in England with a free piece of fruit or a vegetable each school day for the first 3 years of school. The present study examines the impact of the SFVS, in terms of its contribution towards the total daily intake of fruit and vegetables by children across England. Quantitative dietary data were collected from 2306 children in their third year of school, from 128 schools, using a 24 h food diary. The data were examined at different spatial scales, and variations in the impact of the scheme across areas with different socio-economic characteristics were analysed using a deprivation index and a geodemographic classification. The uptake of the SFVS and the total intake of fruit and vegetables by children varied across different parts of England. Participation in the SFVS was positively associated with fruit and vegetable consumption. That is, in any one area, those children who participated in the SFVS consumed more fruit and vegetables. However, children living in deprived areas still consumed less fruit and vegetables than children living in more advantaged areas: the mean daily frequency of fruit and vegetables consumed, and rates of consumption of fruit or vegetables five times or more per d, decreased as deprivation increased (r − 0·860; P = 0·001; r − 0·842; P = 0·002). So the SFVS does not eliminate the socio-economic gradient in fruit and vegetable consumption, but it does help to increase fruit and vegetable consumption in deprived (and affluent) areas.
A score that verifies adherence to a gluten-free diet: a cross-sectional, multicentre validation in real clinical life
Authors: Biagi Federico , Bianchi Paola Ilaria , Marchese Alessandra , Trotta Lucia , Vattiato Claudia , Balduzzi Davide , Brusco Giovanna , Andrealli Alida , Cisarò Fabio , Astegiano Marco , Pellegrino Salvatore , Magazzù Giuseppe , Klersy Catherine , Corazza Gino Roberto 
Published: February 2012

A dietary interview performed by expert personnel is the best method to check whether patients with coeliac disease follow a strict gluten-free diet (GFD). We previously developed a score based on four fast and simple questions that can be administered even by non-expert personnel. The aim of the present study is to verify the reliability of our questionnaire in a new cohort of patients. The questionnaire has a five-level score. From March 2008 to January 2011, the questionnaire was administered to 141 coeliac patients on a GFD, who were undergoing re-evaluation. The score obtained was compared with persistence of both villous atrophy and endomysial antibodies (EMA). The rate of lower scores was higher among the patients with persistence of either villous atrophy (Fisher's exact, P < 0·001; test for trend, P < 0·001) or positive EMA (Fisher's exact, P = 0·001; test for trend, P = 0·018). Given that the coeliac patients have been well instructed on what a GFD means and on how to follow it, our questionnaire is a reliable and simple method to verify compliance to a GFD.
SECULARIZATION AND RELIGIOUS EXPERIENCE: ARGUMENTS IN THE HISTORIOGRAPHY OF MODERN BRITISH RELIGION
Authors: MORRIS JEREMY 
Published: February 2012

ABSTRACTThe historiography of religion in modern Britain has been dominated in recent years by controversy over the sociological theory of secularization. This review of the literature on secularization in modern Britain traces its apparent persuasiveness in part to assumptions about religious decline and renewal which are central to Christian soteriology. Recognition of the nature of secularization theory discloses a monolithic notion of religion itself. Closer attention to the complexity of religious experience may yield an account of religion more attuned to the contours of social change in modern Britain.
HOW OLD! HOW NEW!: SOME NOTES ON SCHOENBERG'S PETRARCH SETTING FOR THE ‘SERENADE’, OP. 24
Authors: Green Edward 
Published: February 2012

AbstractAs the first systematic 12-tone composition, the Petrarch movement from Schoenberg's Serenade has been associated with ‘newness’. Yet it has conservative features. Medieval notions of isomelody and isorhythm, as well as Renaissance concepts of paralleling a poem's prosody and emotional content, are here. Moreover, 12-tone composition itself is an evolution of ‘Chromatic Completion’ – a technique already flourishing in Haydn and Mozart. Ultimately, what matters most is Schoenberg's understanding of the aesthetics of love. To appreciate this, the essay makes use of the philosophy of Aesthetic Realism, founded by the great American poet and scholar Eli Siegel. Beauty, he taught, is ‘a making one of opposites, and the making one of opposites is what we are going after in ourselves’. And love, he explained, has an aesthetic basis: it is ‘proud need’. This essay indicates technical ways in which Schoenberg illustrates the truth of these concepts.
Flank instability structure of Mt. Etna inferred by a magnetotelluric survey
Authors: Siniscalchi Agata , Tripaldi Simona , Neri Marco , Balasco Marianna , Romano Gerardo , Ruch Joel , Schiavone Domenico 
Published: February 2012

This paper presents a magnetotelluric (MT) survey of the unstable eastern flank of Mt. Etna. We take thirty soundings along two profiles oriented in the N‐S and NW‐SE directions, and from these data recover two 2D resistivity models of the subsurface. Both models reveal three major layers in a resistive‐conductive‐resistive sequence, the deepest extending to 14 km bsl. The shallow layer corresponds to the volcanic cover, and the intermediate conductive layer corresponds to underlying sediments segmented by faults. These two electrical units are cut by ∼ E‐W‐striking faults. The third layer (basement) is interpreted as mainly pertinent to the Apennine‐Maghrebian Chain associated with ∼ SW‐NE‐striking regional faults. The detailed shapes of the resistivity profiles clearly show that the NE Rift is shallow‐rooted (∼0–1 km bsl), thus presumably fed by lateral dikes from the central volcano conduit. The NW‐SE profile suggests by a series of listric faults reaching up to 3 km bsl, then becoming almost horizontal. Toward the SE, the resistive basement dramatically dips (from ∼3 km to ∼10 km bsl), in correspondence with the Timpe Fault System. Several high‐conductivity zones close to the main faults suggest the presence of hydrothermal activity and fluid circulation that could enhance flank instability. Our results provide new findings about the geometry of the unstable Etna flank and its relation to faults and subsurface structures.
Russian Agriculture during Transition: Performance, Global Impact, and Outlook
Authors: Liefert William M. , Liefert Olga 
Published: February 2012

AbstractIn the 2000s, Russia emerged as a major player in world agricultural markets, on both the supply (mainly grain) and demand side. This article examines Russia's agricultural transition experience, which has resulted in a complex system of diverse producers and institutions, as well as uneven performance. Using a model of transition agriculture, the article explores how key reform policies drove systemic change and commodity restructuring, and how the ensuing changes in the production, consumption, and trade of goods have affected world markets. The article also assesses the performance of Russian agriculture during transition, and provides an outlook for the future.
A novel significance score for gene selection and ranking
Authors: Xiao Yufei , Hsiao Tzu-Hung , Suresh Uthra , Chen Hung-I Harry , Wu Xiaowu , Wolf Steven E. , Chen Yidong 
Published: February 2012

AbstractMotivation: When identifying differentially expressed (DE) genes from high-throughput gene expression measurements, we would like to take both statistical significance (such as P-value) and biological relevance (such as fold change) into consideration. In gene set enrichment analysis (GSEA), a score that can combine fold change and P-value together is needed for better gene ranking.Results: We defined a gene significance score π-value by combining expression fold change and statistical significance (P-value), and explored its statistical properties. When compared to various existing methods, π-value based approach is more robust in selecting DE genes, with the largest area under curve in its receiver operating characteristic curve. We applied π-value to GSEA and found it comparable to P-value and t-statistic based methods, with added protection against false discovery in certain situations. Finally, in a gene functional study of breast cancer profiles, we showed that using π-value helps elucidating otherwise overlooked important biological functions.Availability: http://gccri.uthscsa.edu/Pi_Value_Supplementary.aspContact: xy@ieee.org, cheny8@uthscsa.eduSupplementary information: Supplementary data are available at Bioinformatics online.
The Effects of Ketorolac on Microvascular Thrombosis in Lower Extremity Reconstruction
Authors: Lee Kyeong Tae , Jeon Byung-Joon , Lim So-Young , Pyon Jai-Kyung , Bang Sa-Ik , Oh Kap-Sung , Mun Goo-Hyun 
Published: February 2012

Background:
Ketorolac is commonly prescribed for relieving postoperative pain and is known to have an anticoagulation effect, though this has not been studied in a clinical series. The aim of this study was to evaluate the effects of ketorolac on microvascular thrombosis in lower extremity reconstruction.

Methods:
A retrospective chart review was performed for patients who underwent lower limb reconstruction with a free flap between January of 2005 and September of 2011. Patients were categorized into two groups based on the administration of ketorolac for postoperative pain relief. Complications were assessed, and the two groups were compared for vascular insufficiency, total or partial flap loss, and hematoma formation.

Results:
A total of 128 patients underwent microsurgical flap transfer, including 111 thoracodorsal artery perforator flaps, four latissimus dorsi myocutaneous flaps, seven deep inferior epigastric artery perforator flaps, and six anterolateral thigh flaps. Eighty patients were administrated ketorolac, and 48 patients were not. The nonketorolac group had significantly higher rates of vascular-related complications, and the difference remained significant after adjusting for confounding factors on multivariate logistic regression analysis. There was a correlation between the duration of ketorolac administration and complication rates, for which longer periods of ketorolac administration yielded lower complication rates.

Conclusion:
Ketorolac administration has a protective effect against the development of microvascular thrombosis and can be a preferred analgesic in free tissue transfer.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, III.
UK recommendations for dietary fat: should they be reassessed in light of the recent joint FAO/WHO recommendations?
Authors: Schenker S. 
Published: February 2012

SummaryIn 2008, the Food and Agricultural Organization (FAO)/World Health Organization (WHO) reviewed its recommendations on dietary fat and fatty acids in light of the growing evidence base on dietary fatty acids and health outcomes. These new FAO/WHO recommendations are considerably broader than the current UK recommendations, in that the FAO/WHO report makes separate recommendations for adults and children and sets ranges of intake for n‐3 and n‐6 polyunsaturated fatty acids (PUFAs) based, not only on prevention of deficiency, but also on their role in contributing to optimum and long‐term health. The key recommendation of this report is that saturated fatty acids (SFAs) should be limited to 10% of dietary energy intake and, compared with the UK recommendations, there is a stronger emphasis on replacing excess dietary SFAs with PUFAs (both n‐3 and n‐6) because of convincing evidence that this dietary exchange reduces low density lipoprotein cholesterol and the risk of coronary heart disease. It may therefore be timely to consider the need for a modification of the UK dietary guidelines on dietary fat and fatty acid intake to take account of the growing evidence base for the potential benefit of replacing SFAs with PUFAs.
ARE EMOTIONS PERCEPTUAL EXPERIENCES OF VALUE?
Authors: Whiting Demian 
Published: February 2012

AbstractA number of emotion theorists hold that emotions are perceptions of value. In this paper I say why they are wrong. I claim that in the case of emotion there is nothing that can provide the perceptual modality that is needed if the perceptual theory is to succeed (where by ‘perceptual modality’ I mean the particular manner in which something is perceived). I argue that the five sensory modalities are not possible candidates for providing us with ‘emotional perception’. But I also say why the usual candidate offered – namely feeling or affectivity – does not give us the sought‐after perceptual modality. I conclude that as there seems to be nothing else that can provide the needed perceptual modality, we should reject the perceptual theory of emotion.1
A systematic review of the literature on the treatment of pityriasis rubra pilaris type 1 with TNF‐antagonists
Authors: Petrof G. , Almaani N. , Archer C.B. , Griffiths W.A.D. , Smith C.H. 
Published: February 2012

AbstractBackground  Adult pityriasis rubra pilaris (PRP) type 1 is a rare chronic papulosquamous disorder with clinical and histological parallels with psoriasis. Treatment is challenging and recent case reports suggest a potential role for tumour necrosis factor (TNF) antagonists.Objectives  Our objective was to systematically review the literature for evidence of efficacy of TNF antagonists in the treatment of adult PRP.Methods  We performed a systematic search of the Cochrane library, EMBASE, Pubmed and MEDLINE databases. We defined diagnosis of PRP, classified clinical response and whether this was clearly attributed to TNF‐antagonists. We also reviewed disease, treatment duration and follow up.Results  Sixteen articles were selected for detailed review. From these, 12 articles (13 cases) met our predefined criteria and were included in the systematic review. The authors identified two more cases from their personal archive. A total of 15 evaluable cases were included for analysis. Twelve showed complete response (CR) (80%) to TNF‐antagonists with a mean time to maximal response of 5 months. In 10 of the CR cases (83%) this was clearly attributable to TNF antagonist therapy.Conclusion  These data indicate that TNF‐antagonists may be of value in treating adult type 1 PRP refractory to other systemic agents but selective reporting bias, together with the lack of standard diagnostic criteria and established spontaneous resolution in PRP, prevent any firm recommendations on their place in management.
Dysregulated biomarkers induce distinct pathways in preterm birth
Authors: Brou L , Almli LM , Pearce BD , Bhat G , Drobek CO , Fortunato S , Menon R 
Published: February 2012

Please cite this paper as: Brou L, Almli L, Pearce B, Bhat G, Drobek C, Fortunato S, Menon R. Dysregulated biomarkers induce distinct pathways in preterm birth. BJOG 2012;119:458–473.Objective  To document racial disparity in biomarker concentrations in maternal/fetal plasma and amniotic fluid between African Americans and European Americans with spontaneous preterm birth (PTB; cases) and normal term birth (controls), and their contribution to distinct pathophysiological pathways of PTB.Design  Nested case–control study.Setting  The Perinatal Research Center, Nashville, Tennessee, USA.Sample  Maternal and fetal plasma and amniotic fluid samples were collected from 105 cases (59 African American and 46 European American) and 86 controls (40 African American and 46 European American).Methods  Thirty‐six biomarkers were analysed using the protein microarray approach.Main outcome measures  Differences in biomarker concentrations between cases and controls of different races in maternal, fetal and intra‐amniotic compartments, and the risk of PTB. Dysregulated biomarker‐induced PTB pathways associated with PTB in each race were determined using ingenuity pathway analysis (IPA).Results  Racial disparity was observed in biomarker concentrations in each compartment between cases and controls: amniotic fluid, IL8 and MIP1α differed between case and controls in European Americans, whereas ANGPT2, Eotaxin, ICAM‐1, IL‐1β, IL1RA, RANTES and TNFα differed between case and controls in African Americans. In both races the FAS ligand, MCP‐3 and TNFR‐I differed between cases and controls. For fetal plasma, ANGPT2, Eotaxin, FGF basic, ICAM‐1, IGF‐I, IL10, IL‐1β, IL2, IP10 KGF, MCP‐3, MIP1α, PDGF‐BB, TGFα, TGFβ1, TIMP1, TNFα, TNFR‐I, TNFR‐II and VEGF differed between cases and controls in European Americans, whereas only MMP7 differed between cases and controls in African Americans. IL‐8 differed between cases and controls in both races. For maternal plasma, IL1RA, MMP7 and VEGF differed between cases and controls in European Americans, whereas ANGPT2, FGF basic, IL‐1β, IL5, IL6R, KGF, MCP‐3, MIP1α, TIMP1 and TNFα differed between cases and controls in African Americans. ANG, IL8 and TNFR‐I differed between cases and controls in both races.Conclusions  We conclude that: (1) biomarker concentrations in maternal, fetal and intra‐amniotic compartments differ between cases and controls; (2) there is racial disparity in the biomarker profile in each of the compartments; (3) substantial numbers of dysregulated fetal plasma biomarkers contribute to PTB in European Americans, whereas maternal plasma biomarkers contribute to PTB in African Americans; and (4) both inflammation and haematological functions are associated with PTB in European Americans, but maternal proinflammatory changes dominate PTB in African Americans. Biomarker analyses document racial disparity and the distinct pathophysiological contributions from different compartments that can determine pregnancy outcome.
Clozapine, but not haloperidol, enhances glial d‐serine and L‐glutamate release in rat frontal cortex and primary cultured astrocytes
Authors: Tanahashi Shunske , Yamamura Satoshi , Nakagawa Masanori , Motomura Eishi , Okada Motohiro 
Published: February 2012

BACKGROUND AND PURPOSE Deficient transmission at the glutamate NMDA receptor is considered a key component of the pathophysiology of schizophrenia. However, the effects of antipsychotic drugs on the release of the endogenous NMDA receptor partial agonist, d‐serine, remain to be clarified.EXPERIMENTAL APPROACH We determined the interaction between antipsychotic drugs (clozapine and haloperidol) and transmission‐modulating toxins (tetanus toxin, fluorocitrate, tetrodotoxin) on the release of L‐glutamate and d‐serine in the medial prefrontal cortex (mPFC) of freely moving rats, using microdialysis, and primary cultures of astrocytes using extreme high‐pressure liquid chromatography.KEY RESULTS Release of L‐glutamate and d‐serine in the mPFC and in cultured astrocytes was inhibited by tetanus toxin (a synaptobrevin inhibitor) and fluorocitrate (a glial toxin), whereas tetrodotoxin (a voltage‐sensitive Na+ blocker) inhibited depolarization‐induced L‐glutamate release in the mPFC without affecting that of d‐serine. Clozapine (1 and 5 mg·kg−1), but not haloperidol (0.5 and 1 mg·kg−1), dose‐dependently increased L‐glutamate and d‐serine release from both astrocytes and mPFC. Clozapine‐induced release of L‐glutamate and d‐serine was also reduced by tetanus toxin and fluorocitrate. Tetrodotoxin reduced clozapine‐induced mPFC L‐glutamate release but not that of d‐serine. Clozapine‐induced L‐glutamate release preceded clozapine‐induced d‐serine release. MK‐801 (a NMDA receptor antagonist) inhibited the delayed clozapine‐induced L‐glutamate release without affecting that of d‐serine.CONCLUSIONS AND IMPLICATIONS Clozapine predominantly activated glial exocytosis of d‐serine, and this clozapine‐induced d‐serine release subsequently enhances neuronal L‐glutamate release via NMDA receptor activation. The enhanced d‐serine associated glial transmission seems a novel mechanism of action of clozapine but not haloperidol.