bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Levels of Inflammatory Markers in the Treatment of Stroke Study (Limits): Inflammatory Biomarkers as Risk Predictors after Lacunar Stroke
Authors: Elkind M. S. V. , Luna J. M. , Coffey C. S. , McClure L. A. , Liu K. M. , Spitalnik S. , Paik M. C. , Roldan A. , White C. , Hart R. , Benavente O. 
Published: March 2010

Background Inflammation is increasingly recognised as playing a central role in atherosclerosis, and peripheral blood markers of inflammation have been associated with incident and recurrent cardiac events. The relationship of these potentially modifiable risk markers to prognosis after ischaemic stroke is less clear. The Levels of Inflammatory Markers in the Treatment of Stroke (LIMITS) study will address hypotheses related to the role of inflammatory markers in secondary stroke prevention in an efficient manner using the well-established framework of the Secondary Prevention of Small Subcortical Strokes (SPS3) trial (NCT00059306). Methods SPS3 is an ongoing Phase III multicentre secondary prevention trial focused on preventing recurrent stroke in patients with small vessel ischaemic stroke, or lacunes. In SPS3, patients are assigned in a factorial design to aspirin vs. aspirin plus clopidogrel, and to usual vs. aggressive blood pressure targets. The purpose of LIMITS is to determine whether serum levels of inflammatory markers – including high-sensitivity C-reactive protein, serum amyloid A, CD40 ligand, and monocyte chemoattractant protein-1 – predict recurrent stroke and other vascular events among lacunar stroke patients. The project will also determine whether these markers predict which people will respond best to dual antiplatelet therapy with clopidogrel and aspirin, as well the relationship to cognitive function. Analysis plan Multivariate Cox proportional hazard regression modeling will be used to estimate hazard ratios for the effect of marker levels on risk of recurrent stroke and other outcomes after adjusting for additional potential risk factors, including age, gender, ethnicity, treatment arm, and traditional stroke risk factors. Interactions between marker levels and treatment assignment for both arms of the SPS3 study will be assessed. Observations will be censored at the time of last follow-up visit. Conclusions LIMITS represents an efficient approach to the identification of novel inflammatory biomarkers for use in risk prediction and treatment selection in patients with small vessel disease.
Can the application of a multi‐objective evolutionary algorithm improve conveyance estimation?
Authors: Sharifi Soroosh , Sterling Mark , Knight Donald W. 
Published: March 2010

AbstractThe following work explores the possibility of applying an evolutionary algorithm (NSGA‐II) to automate the calibration procedure of a quasi 2‐D numerical model. Seven rivers are examined, with discharges and flow depths ranging from 6 to 450 m3/s and 0.49 to 3.69 m, respectively. The calibration procedure is based on matching lateral distributions of depth‐mean velocity, for which data exist. The results are compared with simulations undertaken by an expert user using traditional calibration techniques. The new approach compares favourably with the expert user and is able to provide an insight into the optimum calibration parameters, from which further scientific knowledge could be developed.
Blindness following soft tissue trauma in a child with haemophilia A
Authors: Chrcanovic B.R. , Souza L.N. 
Published: March 2010

AbstractTraumatic retrobulbar haemorrhage, if not promptly recognised and treated, may result in acute vision loss because of compression of the optic nerve and its vascular supply. Bleeding disorders or anticoagulant therapy may contribute to the rapid onset of this phenomenon, thus making urgent diagnosis and treatment even more critical. This article reports a case of retrobulbar haemorrhage in an 8‐year‐old boy with factor VIII deficiency (haemophilia A or classic haemophilia) who delayed in seeking professional help and consequently developed permanent blindness. Minor injuries in patients with bleeding disorders or anticoagulant therapy were proven to result in severe complications, especially when these affect the eye.
Microsurgical repair of labial gingival tissues following excision of an epulis: a case report with 18‐month follow‐up
Authors: McCrea S.J.J. 
Published: March 2010

AbstractThe purpose of this study was to describe an alternative surgical approach to simply removing an epulis: The methodology was to both preserve and improve the mucogingival complex. After supportive periodontal therapy that included oral hygiene instruction, scaling and root planning, the patient underwent surgical treatment to remove the tumour. A subepithelial connective tissue graft together with a lateral mucogingival pedicle flap was used to repair the extensive defect.
A technique for exposure of the torus palatinus during reduction surgery
Authors: Christou J. , Gillan G. , Qureshi A. , Hardee P. 
Published: March 2010

AbstractExposure of the torus palatinus during reduction surgery often presents with some difficulties, namely, achieving adequate exposure while minimising trauma to the palatal mucosa. In this article, we describe a simple technique that provides generous access, and further reduces trauma, to the palatal mucosa.
A comparison of natural bone regeneration with that produced by the xenograft Bio‐Oss in the management of an unusual case of adjacent dentigerous cysts
Authors: McCrea S.J.J. , Makdissi J. 
Published: March 2010

AbstractMultiple dentigerous cysts are typically in association with a developmental syndrome. We report the management of a rare case of adjacent cysts in association with a mandibular third molar and a supernumerary molar lying in the ramus, comparing natural bone regeneration with that produced by the xenograft Bio‐Oss (Geistlich Corp., Wolhusen, Switzerland).
Osteonecrosis of the mandible associated with bisphosphonate therapy: report of a case with surgical intervention
Authors: Mochizuki Y. , Omura K. , Kaneoya A. , Kayamori K. , Yamaguchi A. 
Published: March 2010

AbstractNitrogen‐containing bisphosphonates have been widely administered to patients with metastases because of their high efficacy in skeletal complications. Although the exact mechanism of bisphosphonate‐mediated osteoclast inhibition has not been completely elucidated, it was reported recently that nitrogen‐containing bisphosphonates could cause complications of osteomyelitis or osteonecrosis of the jaw. This article reports the long‐term results with an advanced breast cancer patient who suffered osteonecrosis of the mandible when receiving nitrogen‐containing intravenous bisphosphonates therapy. There were serious concerns about the possibility of pathological fracture resulting from the developing osteonecrosis, the patients' quality of life and ultimately their survival prognosis. After consultation with her oncologists about her physical condition and the general surgical risks, we provided positive surgical interventions. At present, the patient has no radiographic or clinical evidence of recurrence 34 months after the surgeries. This report provides information on the benefits of minimal surgical intervention on the quality of life, compared to a wide bone resection performed after pathological fracture has already occurred.
Growth and progression of melanoma and non‐melanoma skin cancers regulated by ubiquitination
Authors: Nakayama Koh 
Published: March 2010

SummaryBasal cell carcinomas (BCC), squamous cell carcinoma (SCC), and melanomas are the major types of skin tumors. Despite being skin cancers, the characteristics of each cancer are widely varied. BCCs often do not proliferate rapidly, and rarely metastasize. Squamous cell carcinomas are more malignant and a certain subtype of SCC is highly metastatic. Melanomas are highly proliferative and invasive, and are most frequently metastatic. Ubiquitin and ubiquitin‐related proteins post‐translationally modify proteins and thereby alter the functions of their target proteins. The ubiquitination process is involved in various physiological responses, including cell growth, cell death, and DNA damage repair. Accumulating evidence suggests that ubiquitin pathways are involved in different types of cancers, including skin cancers. This review describes the major ubiquitin pathways in BCC, SCC, and melanoma. The ubiquitin pathways that are activated among the skin cancers are highly diverse, which might reflect the various characteristics of these three cancer types. Meanwhile, there are also common pathways between BCC, SCC, and melanoma. Therefore, examining the ubiquitin pathways will reveal the mechanisms of these three major skin cancer types and will suggest treatment options.
Exposure keratopathy following silicone frontalis suspension in adult neuro‐ and myogenic ptosis
Authors: van Sorge Arlette J. , Devogelaere Thibaut , Sotodeh Mohammed , Wubbels Rene , Paridaens Dion 
Published: March 2010

Abstract.Purpose:  To evaluate the incidence of exposure keratopathy following silicone frontalis suspension in adult neuro‐ and myogenic blepharoptosis.Method:  Retrospective noncomparative analysis of the charts of 69 cases (101 eyelids) of silicone frontalis suspension.Results:  Sixty‐one patients (93 eyelids) had myogenic ptosis, and eight patients (eight eyelids) had neurogenic ptosis. Preoperative diagnoses included chronic progressive external ophthalmoplegia, myotonic dystrophy, oculopharyngeal dystrophy, third cranial nerve palsy because of trauma or other causes. Average age at the time of operation was 54. Mean interval between the intervention and the first and second postoperative control was 8 and 28 months, respectively. Thirty‐one patients (31 eyelids) needed a second follow‐up visit. Postoperative punctate epithelial erosions (PEE) were encountered most frequently in patients with Steinert’s disease (42% of eyes) and congenital ptosis (33% of eyes). Patients with oculopharyngeal dystrophy did not develop PEE. Corneal ulceration developed in three eyes (two patients): one eye was successfully treated with local antibiotic ointments and lubricants, a bilateral corneal ulceration in the second patient was successfully treated with partial conjunctival grafts.Conclusion:  This study cohort demonstrated a 26% risk of exposure keratopathy following silicone frontalis suspension. The risk of major corneal complications, such as ulceration, was low (3%).
L’ICCROM et l’Afrique : le patrimoine immatériel et le changement du paysage culturel des musées
Authors: Abungu George 
Published: March 2010

RésuméL’Afrique est un continent qui jouit d’un patrimoine naturel et culturel d’une grande richesse et d’une immense diversité. Des cinq grands mammifères sauvages aux hominidés fossiles et à la Grande Vallée du Rift, le continent est bel et bien le berceau de la vie. Son patrimoine immobilier inclut des biens façonnés tant par les hommes que par la nature et occupe des paysages répartis sur tout le continent. Comme dans d’autres parties du monde, les nations africaines – par le biais de l’influence coloniale – ont embrassé la notion et la pratique de la collection, de la conservation et de l’exposition en l’exprimant sous la forme de musées.
Great Expectations: Hindu Revival Movements in Java
Authors: Reuter Thomas 
Published: March 2010

Based on preliminary ethnographic research in five Javanese communities with major Hindu temples, I explore the political history and social dynamics of Hindu revivalism. I reject formalist approaches to the study of religion, including the notion of ‘syncretism’ and instead, treat the Hindu revival movements as an illustration of how social agents employ religious or secular concepts and values in their strategic responses to the particular challenges and crises they may face in a specific cultural, social, political and historical setting.Expectations of a great crisis at the dawn of a new golden age among followers of the Javanese Hindu revival movement are an expression of utopian prophesies and political hopes more widely shared among contemporary Indonesians. These expectations are set to shape the prospects of Indonesia's fledgling democracy. The paper reflects on the historical conditions under which these and similar utopian expectations and associated social movements may either incite violent conflict or serve a positive role in the creation or maintenance of a fair society.
Regulation of Virulence of Entamoeba histolytica by the URE3-BP Transcription Factor
Authors: Gilchrist Carol A. , Moore Ellyn S. , Zhang Yan , Bousquet Christina B. , Lannigan Joanne A. , Mann Barbara J. , Petri William A. 
Published: March 2010

ABSTRACTIt is not understood why only some infections withEntamoeba histolyticaresult in disease. The calcium-regulated transcription factor upstream regulatory element 3-binding protein (URE3-BP) was initially identified by virtue of its role in regulating the expression of two amebic virulence genes, the Gal/GalNac lectin and ferredoxin. Here we tested whether this transcription factor has a broader role in regulating virulence. A comparison ofin vivotoin vitroparasite gene expression demonstrated that 39% ofin vivoregulated transcripts contained the URE3 motif recognized by URE3-BP, compared to 23% of all promoters (P< 0.0001). Amebae induced to express a dominant positive mutant form of URE3-BP had an increase in an elongated morphology (30% ± 6% versus 14% ± 5%;P= 0.001), a 2-fold competitive advantage at invading the intestinal epithelium (P= 0.017), and a 3-fold increase in liver abscess size (0.1 ± 0.1 g versus 0.036 ± 0.1 g;P= 0.03). These results support a role for URE3-BP in virulence regulation.IMPORTANCEAmebic dysentery and liver abscess are caused byEntamoeba histolytica. Amebae colonize the colon and cause disease by invading the intestinal epithelium. However, only one in fiveE. histolyticainfections leads to disease. The factors that govern the transition from colonization to invasion are not understood. The transcription factor upstream regulatory element 3-binding protein (URE3-BP) is a calcium-responding regulator of theE. histolyticaGal/GalNAc lectin and ferredoxin genes, both implicated in virulence. Here we discovered that inducible expression of URE3-BP changed trophozoite morphology and promoted parasite invasion in the colon and liver. These results indicate that one determinant of virulence is transcriptional regulation by URE3-BP.
Seasonal pattern of matric suctions in highway subgrades
Authors: Nguyen Quan , Fredlund Delwyn G. , Samarasekera Lal , Marjerison Brent L. 
Published: March 2010

The performance of “thin membrane surface” (TMS) highways is largely controlled by the strength of the subgrade soil, which in turn is a function of matric suction. Thermal conductivity matric suction sensors were used to indirectly measure in situ matric suctions. In September 2000, 32 thermal conductivity sensors were installed under TMS highways at two locations; namely, Bethune and Torquay, Saskatchewan, Canada, to monitor matric suction and temperature changes with time. This paper presents and interprets the variations in matric suctions measured between the years 2000 and 2005 at the Torquay site. The readings in the field showed a clearly seasonal pattern of matric suction changes that bore a relationship to rainfall near the test sites. Relatively constant equilibrium matric suctions that ranged from 20 to 60 kPa throughout the years were measured under the driving lanes. Conversely, matric suctions under the side slopes were found to vary widely with time and depth, ranging from 100 to 1500 kPa over the years. The greatest variation in matric suction from one location to another location occurred during the month of April. The matric suctions showed low variability during June, whereas larger variations were observed from July to October.
Assessment of deep compaction of the Péribonka dam foundation using “modal analysis of surface waves” (MASW)
Authors: Karray Mourad , Lefebvre Guy , Ethier Yannic , Bigras Annick 
Published: March 2010

The construction of the Péribonka dam has involved deep compaction of its foundation using vibroflotation and dynamic compaction. Due to the presence of gravel and cobble-size particles, surface wave testing was used in addition to classical tests (cone penetration tests (CPTs) and standard penetration tests) for the assessment of compaction. More than 900 shear wave velocity (Vs) profiles down to bedrock or to a maximum depth of 50 m were determined using “modal analysis of surface waves” (MASW). The large number of Vsprofiles, before and after compaction, has allowed a good evaluation of the compaction performance and offered, at the same time, a unique opportunity to demonstrate the potential of surface waves in geotechnical investigations.
Zur Differenzierung bakterieller und mykotischer Granulome
Authors: Schiefer B. 
Published: March 2010

The causative agents of mycotic granulomas can almost always be diagnosed histologically with adequate certainty by the application of special stains for fungi; this is in contrast to the bacterial granulomas, whose histologic appearance permits no certain conclusions and which therefore require cultures as an adjunct to diagnosis. In addition, the histologic picture also shows whether there has actually been an interaction between the body and the fungus. To be sure, cultures are necessary to distinguish the species of certain genera: e.g., Candida, Aspergillus, Penicillium and Mucor; however, of the two, cultures can more readily be dispensed with. It is necessary to distinguish more strictly than heretofore between the infections that have been lumped under actinomycosis; these are true actinomycosis, actinobacillosis, nocardiosis, streptothricosis and bacterial granulomas with sulfur granule formation, e.g., staphylococcal granulomas. The means for distinguishing between these are discussed. The more or less pronounced granulomatous character of the numerous bacterial or fungal inflammations is a peculiar attribute of these processes; it is better to use the more general term “infectious granulomas” rather than “specific inflammations”. The histologic appearance of the lesion and the causative organism is illustrated for several of the infectious granulomas of animals.
Über das Lungenkarzinom bei Tieren mit besonderer Berücksichtigung des Rindes
Authors: Swoboda R. 
Published: March 2010

Five bovine lung carcinomas are described, four of which are metastases of probable uterine carcinoma. Lung carcinomas do not seem to be rare in cattle; in most cases they represent metastases from primary sites in the uterus. A fifth case, was a primary non-keratinizing squamous cell carcinoma of the lung. For differential diagnosis lung carcinomas in cattle must be distinguished from tuberculosis, mycosis and actinomycosis. Three cases of primary lung carcinomas are also described in dogs, two alveolar carcinomas and one non-keratinizing squamous-cell carcinoma; and a primary lung carcinoma each in a cat (non-keratinizing squamous cell carcinoma) and in a guinea pig. In the guinea pig the tumor was associated with a chronic purulent bronchopneumonia and a chronic interstitial pneumonia.
Congenital Cardiac Anomalies in Horses
Authors: Rooney James R. , Franks W. Craig 
Published: March 2010

The available literature on congenital cardiac anomalies in the horse has been reviewed. Five additional cases have been described: two of right atrio-ventricular (tricuspid) atresia with subaortic septal defect and patent foramen ovale, one of congenital absence of the aortic origin of the left coronary artery, one of persistent truncus arteriosus, and one of persistent ductus arteriosus. Four of these cases (exception: persistent truncus arteriosus) have not been previously described in the horse, and represent the only four cardiac anomalies observed in an autopsy series of approximately 2,500 horses, foals and equine fetuses.
The Pathology of Hypervitaminosis D in Cattle
Authors: Capen Charles C. , Cole Clarence R. , Hibbs John W. 
Published: March 2010

Experimental hypervitaminosis D was produced in cows by the daily feeding of 30 million U.S.P. units of vitamin D for varying periods of time. Cardiovascular mineralization was not present after 7 days, but was observed after 10 days and became extensive and widespread after 21 and 30 days. Pregnant cows developed more severe lesions than non-pregnant ones. In the heart, the lesions were more severe on the left side, and consisted of subendocardial mineralization and hemorrhage. In the elastic arteries, the degree of mineralization was maximal proximally, and diminished in severity distally. In the muscular arteries, the mineral deposits when confined to the media were accompanied by a proliferative intimal reaction. The veins were less severely affected than the arteries. Histochemically the mineral deposits contained abundant calcium and phosphorus. X-ray diffraction studies indicated the principal inorganic product of the vitamin D-induced mineralization was a carbonate hydroxyapatite, comparable in crystallochemical characteristics to that of bone.
A Meningo-Leucoencephalomyelitis Resembling Visna in Dutch Zwoeger Sheep
Authors: Ressang A. A. , Stam F. C. , De Boer G. F. 
Published: March 2010

Zwoegerziekte is a disease in Dutch sheep which morphologically closely resembles an Icelandic sheep disease, Maedi2. Chronic lung affection and emaciation are the principal symptoms of both diseases. Visna is another chronic condition in Icelandic sheep affecting mainly the C.N.S. A virus has been isolated from sheep affected with Maedi or Visna and a close relationship in properties has been found between both viruses. In two Dutch sheep autopsied in the final stage of Zwoegerziekte, lesions were present in the C.N.S., which histologically resembled those in Visna. Another sheep slaughtered at the municipal abattoir, with lung lesions characteristic for the terminal stage of Zwoegerziekte, exhibited early cerebral lesions resembling Visna. The lesions in the C.N.S. of these three sheep were meningitis and severe encephalomyelitis of the glial type affecting the white matter. Secondary demyelination was striking. Though Zwoegerziekte has been known for several decades in the Netherlands, the accompanying C.N.S. lesions are described for the first time.
Übertragungsversuche mit aviären Myelozytomen (tumorförmige Chloroleukose, s. Chlorome)
Authors: Löliger H. Ch. , Schubert H. J. 
Published: March 2010

In serienmässig durchgeführten übertragungsversuchen mit einem aus einer spontanen Myelozytomatose isolierten Leukosestamm gelang es in fast allen Passagen bei einem Teil der Versuchstiere Myelozytome u. Myelozytomatosen zu erzeugen. Die übertragung war sowohl bei Verwendung von Gewebshomogenisatsuspensionen als auch bei Verwendung von zellfreiem Blutplasma erfolgreich. Bei 10,5% von 1335 Versuchstieren entwickelten sich typische Myelozytome und generalisierte Myelozytomatosen, die z. T. aber noch mit anderen Verlaufsformen der myelogenen Leukose vergesellschaftet waren. Die bei 27,1% der Tiere ent-standenen Veränderungen betrafen ausschliesslich andere Leukoseformen, wie Erythroblastose und akute Myelosen, Myeloblastosen und Stammzellenleukose. Die aviären Myelozytome zeigten grosse Ähnlichkeit mit den Chloromen und Chloroleukosen der Menschen und der Säugetiere. Das Myelozytom gehört als besondere Verlaufsform in den ätiologischen Komplex der myelogenen Leukosen.