bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: A General Methodology for the Enantioselective Synthesis of 1‐Substituted Tetrahydroisoquinoline Alkaloids.
Authors: Amat Mercedes , Elias Viviane , Llor Nuria , Subrizi Fabiana , Molins Elies , Bosch Joan 
Published: November 2010

AbstractStarting from the known tricyclic lactam (I), a three‐step synthetic route to 1‐substituted tetrahydroisoquinoline alkaloids is presented.
ChemInform Abstract: Room Temperature, Copper‐Catalyzed Amination of Bromonaphthyridines with Aqueous Ammonia.
Authors: Anderson Cyrus A. , Taylor Phillip G. , Zeller Mary A. , Zimmerman Steven C. 
Published: November 2010

AbstractThe resulting aminonaphthyridines can smoothly be converted into synthetically useful nonsymmetric 2,7‐diamidonaphthyridines.
ChemInform Abstract: Stereoselective Synthesis of Pyrano[3,2‐c]‐ and Furano[3,2‐c]quinolines: Gadolinium Chloride Catalyzed One‐Pot Aza‐Diels—Alder Reactions.
Authors: Yu Yong , Zhou Jun , Yao Zhigang , Xu Fan , Shen Qi 
Published: November 2010

AbstractThe three‐component aza‐Diels—Alder reaction between dihydrofuran or dihydropyran (I), aromatic amines (II), and aromatic aldehydes (III) proceeds stereoselectively providing the cis products (IV) with 86% selectivity on average.
ChemInform Abstract: Reduction of Dipyrido Ureas via 6‐Alkyloxydipyrido[1,2‐c;2′,1′‐e]imidazolium Salts.
Authors: Kunz Doris , Deissler Christine , Gierz Verena , Rominger Frank , Oeser Thomas 
Published: November 2010

AbstractReduction of dipyrido uronium salts (VI), which are readily synthesized by alkylation of dipyrido ureas (IV) with Meerwein′s reagent, offers a new and mild synthetic route to dipyridoimidazolium salts (VII).
ChemInform Abstract: Silver Triflate‐Catalyzed Three‐Component Reaction of 2‐Alkynylbenzaldehyde, Sulfonohydrazide, and α,β‐Unsaturated Carbonyl Compound.
Authors: Ye Shengqing , Yang Xiaodi , Wu Jie 
Published: November 2010

AbstractA variety of pyrazolo[5,1‐a]isoquinolines (III) is readily prepared by a silver‐catalyzed three‐component reaction (26 examples).
ChemInform Abstract: Synthesis of Pyridazinedione Derivatives Starting from Anhydrides of 2,3‐Pyridine‐ and 2,3‐Quinolinedicarboxylic Acids.
Authors: Sakhautdinov I. M. , Tukhvatullin O. R. , Fatykohov A. A. , Galin F. Z. 
Published: November 2010

AbstractA similar reaction sequence with comparable yields is carried out starting from 2,3‐quinolinedicarboxylic acid anhydride.
ChemInform Abstract: Alkoxy‐5‐nitrosopyrimidines: Useful Building Block for the Generation of Biologically Active Compounds.
Authors: Marchal Antonio , Nogueras Manuel , Sanchez Adolfo , Low John N. , Naesens Lieve , De Clercq Erik , Mulguizo Manuel 
Published: November 2010

AbstractThe substitution of methoxy groups of nitrosobis(methoxy)pyrimidine (I) by various aliphatic and aromatic amines is studied.
ChemInform Abstract: Mild and Efficient Synthesis of Aryliodonium Ylides of 2,6‐Dimethylpyrimidin‐4‐ol.
Authors: Kumar Ravi , Nair Reshmi R. , Prakash Om 
Published: November 2010

AbstractThe reaction of dimethylpyrimidinol (I) with dichloroiodoarenes (II) in aqueous medium provides an easy access to aryliodonium ylides (III).
ChemInform Abstract: The Specific Character of the Reaction of Derivatives of 2‐Thioxo‐2,3‐dihydropyrimidin‐4(1H)‐one with Iodomethane and Alkyl Chloromethyl Sulfides.
Authors: Novakov I. A. , Orlinson B. S. , Nawrozkij M. B. , Mai A. , Artico M. , Rotili D. , Eremiychuk A. S. , Gordeeva E. A. , Brunilina L. L. , Este J. A. 
Published: November 2010

AbstractThe 2‐{[(allylsulfanyl)methyl]sulfanyl}pyrimidin‐4(3H)‐one derivatives (IIIb)‐(IIId) show high anti‐HIV‐1 activities.
ChemInform Abstract: A Novel and Efficient Methodology for the Construction of Quinazolines Based on Supported Copper Oxide Nanoparticles.
Authors: Zhang Jintang , Yu Chenmin Yu , Wang Sujing , Wan Changfeng , Wang Zhiyong 
Published: November 2010

AbstractThe reaction of aminobenzophenones (I) with benzylic amines (II) in the presence of a new heterogeneous catalyst based on CuO nanoparticles and tert‐butyl hydroperoxide as oxidant leads to the desired quinazolines (III) (28 examples) in moderate to high yields.
ChemInform Abstract: Direct B‐Alkyl Suzuki—Miyaura Cross‐Coupling of 2‐Halopurines. Practical Synthesis of ST1535 (VII), a Potent Adenosine A2A Receptor Antagonist.
Authors: Bartoccini Francesca , Cabri Walter , Celona Diana , Minetti Patrizia , Piersanti Giovanni , Tarzia Giorgio 
Published: November 2010

AbstractPd‐catalyzed treatment of the halopurines (I) with BBu3 and BEt3 allows mild, efficient, and regioselective access to 2‐alkylated purines.
ChemInform Abstract: A Convenient Preparation of Diastereomerically Pure, Diversely Substituted Piperazine‐2,5‐diones from N‐Protected α‐Amino Acids.
Authors: Nikulnikov Mikhail , Shumsky Alexei , Krasavin Mikhail 
Published: November 2010

AbstractA convenient protocol for the synthesis of diastereomerically pure trans‐products is demonstrated.
ChemInform Abstract: A Facile Synthesis of Annulated Thiatriazine Dioxides.
Authors: Khodachenko Alexander N. , Shivanyuk Alexander N. , Shishkina Svetlana V. , Shishkin Oleg V. , Nazarenko Konstantin G. , Tolmachev Andrey A. 
Published: November 2010

AbstractSulfamoylamidines react with carbonyl compounds (generally aromatic aldehydes) to give the title compounds (III)(34 examples) which can be further functionalized at the free NH position.
ChemInform Abstract: Furan Ring Opening—Pyrrole Ring Closure: A New Synthetic Route to Aryl(heteroaryl)‐Annulated Pyrrolo[1,2‐a][1,4]diazepines.
Authors: Butin Alexander V. , Nevolina Tatyana A. , Shcherbinin Vitaly A. , Trushkov Igor V. , Cheshkov Dmitry A. , Krapivin Gennady D. 
Published: November 2010

AbstractAcid‐mediated recyclization of N‐(furfuryl)anthranilamides, e.g. (I), affords title (het)aryl‐annulated pyrrolo[1,2‐a]diazepines in moderate yields.
ChemInform Abstract: Conjugate Additions, Aza‐Cope, and Dissociative Rearrangements and Unexpected Electrocyclic Ring Closures in the Reactions of 2‐(2‐Pyrrolidinyl)‐Substituted Heteroaromatic Systems with Acetylenic Sulfones.
Authors: Weston Mitchell H. , Parvez Masood , Back Thomas G. 
Published: November 2010

AbstractThe pyrrolidines (I) and the imidazolidine (IV) react with acetylenic sulfones to afford the 7‐membered heterocycles (III) and (VI) via conjugative addition, dissociation of the C—N bond, and subsequent cyclization.
ChemInform Abstract: Intramolecular 1,3‐Dipolar Cycloaddition as a Route to Triazolobenzodiazepines and Pyrrolobenzodiazepines.
Authors: Chambers Christopher S. , Patel Nilesh , Hemming Karl 
Published: November 2010

AbstractTreatment of aldehydes (I) and (IV) with Bestmann—Ohira reagent (II) results in formation of alkynes which undergo intramolecular 1,3‐dipolar cycloaddition with the azide moiety to furnish the target skeletons.
ChemInform Abstract: Facile Access to Boryltetralins and Borylnaphthalenes via a Cycloaddition Using o‐Quinodimethanes.
Authors: Yoshida Hiroto , Mukae Masashi , Ohshita Joji 
Published: November 2010

AbstractThe reaction of borylalkenes (I) with in situ generated o‐quinodimethanes gives rise to anti‐boryltetralins (III), which are readily converted into borylnaphthalenes (IV) by oxidative aromatization.
ChemInform Abstract: Synthesis of Terminal Acetylenes Using POCl3 in Pyridine as Applied to Natural Triterpenoids.
Authors: Kazakova Oxana B. , Medvedeva Natalya I. , Tolstikov Genrikh A. , Kukovinets Olga S. , Yamansarov Emil Y. , Spirikhin Leonid V. , Gubaidullin Aidar T. 
Published: November 2010

AbstractFour new triterpenoids with alkyne moieties are efficiently synthesized.
ChemInform Abstract: Synthesis Enables a Structural Revision of the Mycobacterium tuberculosis‐Produced Diterpene, Edaxadiene (I).
Authors: Spangler Jillian E. , Carson Cheryl A. , Sorensen Erik J. 
Published: November 2010

AbstractRevision of the spectral data of edaxadiene leads to proposal of a new structure, namely (I).
ChemInform Abstract: Australin E Isolated from the Soft Coral Cladiella sp. Collected in Pohnpei Activates the Inositol 5‐Phosphatase SHIP1.
Authors: Williams David E. , Amlani Ashraf , Dewi Ariyanti S. , Patrick Brian O. , van Ofwegen Leen , Mui Alice L.‐F. , Andersen Raymond J. 
Published: November 2010

AbstractAmong the australins E (I) ‐H (IV), only (I) is found to be active.
ChemInform Abstract: Highly Stereoselective Synthesis of Substituted Prolyl Peptides Using a Combination of Biocatalytic Desymmetrization and Multicomponent Reactions.
Authors: Znabet Anass , Ruijter Eelco , de Kanter Frans J. J. , Koehler Valentin , Helliwell Madeleine , Turner Nicholas J. , Orru Romano V. A. 
Published: November 2010

Abstract3,4‐Disubstituted 1‐pyrrolines (I) and (V) generated from the corresponding meso‐pyrrolidines by biocatalytic desymmetrization with monoamine oxidase N, react with carboxylic acids (II) and isocyanides (III) in a highly diastereoselective Ugi‐type multicomponent reaction to give substituted prolyl peptides (IV) and (VI) with high enantioselectivities.
ChemInform Abstract: Isolation of Two New Terpeptin Analogues — JBIR‐81 and JBIR‐82 — from a Seaweed‐Derived Fungus, Aspergillus sp. SpD081030G1f1.
Authors: Izumikawa Miho , Hashimoto Junko , Takagi Motoki , Shin‐ya Kazuo 
Published: November 2010

AbstractThe two new terpeptin analogues JBIR‐81 (Ia) and JBIR‐82 (Ib) show stronger radical‐scavenging activities than the representative antioxidant α‐tocopherol.
ChemInform Abstract: Synthesis of N‐, S‐, and C‐Glycoside Castanospermine Analogues with Selective Neutral α‐Glucosidase Inhibitory Activity as Antitumor Agents.
Authors: Sanchez‐Fernandez Elena M. , Risquez‐Cuadro Rocio , Chasseraud Maud , Ahidouch Ahmed , Ortiz Mellet Carmen , Ouadid‐Ahidouch Halima , Garcia Fernandez Jose M. 
Published: November 2010

AbstractThree novel castanospermine analogues (III), (VIII), and (XIII) are synthesized and found to display selective inhibitory activity against neutral α‐glucosidase as well as promising anticancer activity against human breast carcinoma cell lines.
ChemInform Abstract: Aspernidine A and B, Prenylated Isoindolinone Alkaloids from the Model Fungus Aspergillus nidulans.
Authors: Scherlach Kirstin , Schuemann Julia , Dahse Hans‐Martin , Hertweck Christian 
Published: November 2010

AbstractThe prenylated isoindolinone alkaloids aspernidine A (Ia) and B (Ib) are isolated from the model fungus Aspergillus nidulans.
ChemInform Abstract: Synthesis and anti‐HIV Activity of 2′‐Deoxy‐2′‐fluoro‐4′‐C‐ethynyl Nucleoside Analogues.
Authors: Wang Qiang , Li Yanfeng , Song Chuanjun , Qian Keduo , Chen Chin‐Ho , Lee Kuo‐Hsiung , Chang Junbiao 
Published: November 2010

AbstractBased on the favorable antiviral profiles of 4′‐substituted nucleosides, novel cytosine (Ia), uracil (Ib), and thymine (Ic) analogues are synthesized.
ChemInform Abstract: New Tensidols, JBIR‐86 and JBIR‐87, Isolated from Aspergillus sp. fJ80.
Authors: Takagi Motoki , Motohashi Keiichiro , Hwang Ji‐Hwan , Nagai Aya , Shin‐ya Kazuo 
Published: November 2010

AbstractThe new tensidols JBIR‐86 (Ia) and JBIR‐87 (Ib) are isolated from Aspergillus sp.
ChemInform Abstract: Enantiodivergent Formal Total Synthesis of Aspercyclide C from L‐(+)‐Tartaric Acid
Authors: Prasad Kavirayani R. , Gandi Vasudeva Rao , Nidhiry John Eugene , Bhat Kavya S. 
Published: November 2010

Abstractpreparation of both enantiomers
ChemInform Abstract: A Highly Rearranged Pentaprenylxanthonoid from the Resin of Garcinia hanburyi.
Authors: Tao Si‐Jia , Guan Shu‐Hong , Li Xing‐Nuo , Guo De‐An 
Published: November 2010

AbstractCompounds (I), (II) and (III) exhibit modest activity against HeLa tumor cell line.
ChemInform Abstract: Three New Phenylpropanoids from Inula nervosa Wall.
Authors: Yan Lan , Huang Ying , Fu Jian‐Jun , Qin Jiang‐Jiang , Zeng Qi , Zhu Yan , Yan Shi Kai , Zhang Wei‐Dong , Jin Hui‐Zi 
Published: November 2010

AbstractThe new compounds (I) exhibit mild inhibitory effects against NO production in LPS‐stimulated RAW264.7 cells.
ChemInform Abstract: Symmetry Switch of Cobalt Ferrocyanide Framework by Alkaline Cation Exchange.
Authors: Matsuda Tomoyuki , Kim Jungeun , Moritomo Yutaka 
Published: November 2010

AbstractK1.88Co [Fe(CN)6]0.97·3.8H2O (I) is obtained from aqueous solutions of KCl, CoCl2, and K4[Fe(CN)6].
ChemInform Abstract: Synthesis of Atomically Thin WO3 Sheets from Hydrated Tungsten Trioxide.
Authors: Kalantar‐zadeh Kourosh , Vijayaraghavan Aravind , Ham Moon‐Ho , Zheng Haidong , Breedon Michael , Strano Michael S. 
Published: November 2010

AbstractNanosheets of atomically thin WO3 layers are prepared by mechanical exfoliation of WO3·2H2O (obtained from pieces of tungsten foil in HNO3 at 80 °C for 6 h) using a piece of an adhesive tape, followed by annealing at 300 °C.
ChemInform Abstract: Synthesis of ortho‐Functionalized 4‐Aminomethylpyridazines as Substrate‐Like Semicarbazide‐Sensitive Amine Oxidase Inhibitors.
Authors: Haider Norbert , Hochholdinger Iris , Matyus Peter , Wobus Andrea 
Published: November 2010

AbstractA series of pyridazines and pyridazin‐3(2H)‐ones bearing alkylamino side chains in ortho‐position relative to the ‐CH2‐NH2 unit (‐Aet) is synthesized.
The interference of heparin on IEF‐PAGE of erythropoietins
Authors: Reichel Christian , Benetka Edmund , Geisendorfer Thomas , Scheiblhofer Veronika , Abzieher Friedrich 
Published: November 2010

AbstractBecause of the risk of suffering a stroke or heart attack, some athletes and their medical supervisors admitted having used anticoagulants (e.g. acetylsalicylic acid) in combination with doping with recombinant erythropoietins (rhEPO). Heparin is one of the oldest and cheapest anticoagulants. The anticoagulative effect of heparin is a result of the binding of heparin to the plasma protein antithrombin III and the subsequent inactivation of blood clotting factors (e.g. factor IIa, IXa, Xa, XIa, XIIa). Heparin—a polyanion—is known to interact with carrier ampholytes used in IEF‐PAGE. Two different types of heparin pharmaceuticals are used for medical purposes: unfractionated heparins (UFH) and low molecular weight heparins (LMWH). Their influence on IEF‐ and SDS‐PAGE was investigated. Only UFH had a profound impact on IEF‐PAGE, leading to excessive smearing or complete abolishment of the EPO IEF‐profile and shifting of acidic EPO‐isoforms in the endogenous region of the gel. No such effect was observable for SDS‐PAGE. Remedies include immunoaffinity purification of EPO before IEF‐PAGE or the treatment of the urinary retentate with solid urea. A combined usage of IEF‐ and SDS‐PAGE is recommended for confirming the presence of rhEPO in urine and for further analysis of smearing (and therefore suspicious) samples. This two‐method approach is already in accordance with the technical document on EPO‐analysis (TD2009EPO) of the World Anti‐Doping Agency (WADA). Copyright © 2010 John Wiley & Sons, Ltd.
Chromanone Derivatives from the Pericarps of Calophyllum polyanthum
Authors: Wang Huan , Sun Qian‐Yun , Yang Fu‐Mei , Long Chun‐Lin , Wang Yue‐Hu , Tang Gui‐Hua , Zhao Fu‐Wei , Niu Hong‐Mei , Huang Qiao‐Qin , Xu Jin‐Jin , Wataya Yusuke , Ma Li‐Juan 
Published: November 2010

AbstractThree new chromanone derivatives, calopolyanic acid (1), isocalopolyanic acid (2), and isorecedensic acid (3), were isolated from the pericarps of Calophyllum polyanthum Wall. ex Choisy, along with seven known compounds, apetalic acid, blancoic acid, chapelieric acid, methyl isoapetalate, isoapetalic acid, isocalolongic acid, and recedensic acid. All of these compounds were reported from C. polyanthum for the first time. The structures of 1–3 were elucidated by spectroscopic methods.
New Glycosidic Constituents of Abutilon pakistanicum
Authors: Ali Bakhat , Fatima Itrat , Malik Abdul , Ahmed Zaheer 
Published: November 2010

AbstractPakisides A and B (1 and 2, resp.), new catalpol‐type iridoid glycosides, and a new glycoside, 3, of scutellarein have been isolated from the AcOEt‐soluble fraction of the whole plant of Abutilon pakistanicum, along with buddlejoside and lapachol. The structures of new compounds were elucidated by spectroscopic techniques including 1H‐and 13C‐NMR (DEPT), and 2D‐NMR experiments.
Three‐Component Reaction of Isocyanides and 2‐Formylbenzoic Acid with Dibenzylamine Catalyzed by Silica Nanoparticles under Solvent‐Free Conditions
Authors: Ramazani Ali , Mahyari Amir 
Published: November 2010

AbstractReaction of an isocyanide with an iminium ion intermediate, formed by reaction between 2‐formylbenzoic acid and dibenzylamine in the presence of silica nanoparticles (silica NP, ca. 42 nm) proceeds smoothly at room temperature to afford isocoumarin (=1H‐2‐benzopyran‐1‐one) derivatives in high yields (Scheme 1 and Table 1).
Unusual Reactions of (+)‐Car‐2‐ene and (+)‐Car‐3‐ene with Aldehydes on K10 Clay
Authors: Il'ina Irina V. , Volcho Konstantin P. , Korchagina Dina V. , Salnikov Georgi E. , Genaev Alexander M. , Karpova Elena V. , Salakhutdinov Nariman F. 
Published: November 2010

AbstractThe reactions of (+)‐car‐2‐ene (1) and (+)‐car‐3‐ene (2) with aldehydes in the presence of montmorillonite clay were studied for the first time (Schemes 3 and 5). The major products of these reactions are optically active, substituted hexahydroisobenzofurans, probably formed as a result of an attack of the protonated aldehyde at the cyclopropane ring. Quite unexpectedly, the products are cis‐configured at the ring‐fusion site; the fact was established by means of quantum‐chemical calculations and NMR data. It appeared that the behavior of the 2 : 3 mixture 1/2 in reactions with aldehydes in the presence of K10 clay differed substantially from the reactivities of the corresponding individual monoterpenes.
Purines. Part XVI
Authors: Mosselhi Mosselhi A. , Pfleiderer Wolfgang 
Published: November 2010

AbstractA series of N‐substituted 8‐aminoxanthines (=8‐amino‐3,7(or 3,9)‐dihydro‐1H‐purine‐2,6‐diones) 8–16 and 34–37 were synthesized from the corresponding 8‐nitroxanthines 1–7, 30–33, and 8‐(phenylazo)xanthines 17 and 18 by catalytic reduction. Another approach was derived from 6‐amino‐5‐(cyanoamino)uracils (=N‐(6‐amino‐1,2,3,4‐tetrahydro‐2,4‐dioxopyrimidin‐5‐yl)cyanamides) 23, 24, and 27 by base‐catalyzed cyclization yielding 25–28. All 8‐aminoxanthines 8–29 and 34–37 were acetylated to the corresponding 8‐(acetylamino)xanthines 40–57, and prolonged heating led to 8‐(diacetylamino)xanthines 58 and 59. Several 8‐aminoxanthines 8–13 were diazotized forming 8‐diazoxanthines 60–64. Coupling reactions of isolated 62 and 64 and intermediary formed 8‐diazoxanthines with 1,3‐dimethylbarbituric acid (=1,3‐dimethylpyrimidine‐2,4,6(1H,3H,5H)‐trione; 66) resulted in 5‐[(xanthin‐8‐yl)diazenyl]‐1,3‐dimethylbarbituric acids=3,7(or 3,9)‐dihydro‐8‐[2‐(1,2,3,4‐tetrahydro‐1,3‐dimethyl‐2,4‐dioxopyrimidin‐5‐yl)diazenyl]‐1H‐purine‐2,6‐diones) 67–80. The newly synthesized xanthine derivatives were characterized by the determination of their pKa values, the UV‐ and NMR spectra, as well as elemental analyses.
Skew deviation after intratympanic gentamicin therapy
Authors: Ng Diana , Fouladvand Mohammad , Lalwani Anil K. 
Published: November 2010

AbstractIntratympanic gentamicin therapy for the treatment of episodic vertigo associated with Ménière's disease is generally well tolerated. Although auditory and vestibular symptoms following intratympanic gentamicin are well known, visual disturbance has not been previously described. In this report, we describe two patients with Ménière's disease who developed sudden onset of binocular vertical diplopia due to skew deviation after intratympanic gentamicin therapy. The skew deviation and diplopia resolved spontaneously and completely within 6 to 8 weeks without therapy. Development of diplopia due to skew deviation should be discussed as a potential complication in patients undergoing intratympanic gentamicin therapy. Laryngoscope, 2011
Changes in U.S. hospitalization and mortality rates following smoking bans
Authors: Shetty Kanaka D. , DeLeire Thomas , White Chapin , Bhattacharya Jayanta 
Published: November 2010

AbstractU.S. state and local governments have increasingly adopted restrictions on smoking in public places. This paper analyzes nationally representative databases, including the Nationwide Inpatient Sample, to compare short‐term changes in mortality and hospitalization rates in smoking‐restricted regions with control regions. In contrast with smaller regional studies, we find that smoking bans are not associated with statistically significant short‐term declines in mortality or hospital admissions for myocardial infarction or other diseases. An analysis simulating smaller studies using subsamples reveals that large short‐term increases in myocardial infarction incidence following a smoking ban are as common as the large decreases reported in the published literature. © 2010 by the Association for Public Policy Analysis and Management.
Hemophagocytic lymphohistiocytosis in children with chronic granulomatous disease
Authors: Parekh Chintan , Hofstra Thomas , Church Joseph A. , Coates Thomas D. 
Published: November 2010

AbstractHemophagocytic lymphohistiocytosis (HLH) is characterized by fever, cytopenias, splenomegaly, and hemophagocytosis by macrophages activated by high cytokine levels. Chronic granulomatous disease (CGD) is characterized by recurrent infections, hyperinflammation, and excessive cytokine release. This may predispose patients with CGD to developing HLH during an infection. We conducted a retrospective review of patients with CGD, treated at our institution between 1999 and 2008. Three out of 17 patients developed HLH. Patients with CGD may be at increased risk for developing HLH. Remission of HLH was achieved after treatment with antimicrobials, steroids, and intravenous immunoglobulin This approach to treatment appears to be effective. Pediatr Blood Cancer 2011;56:460–462. © 2010 Wiley‐Liss, Inc.
Successful treatment of a child with T/myeloid acute bilineal leukemia associated with TLX3/BCL11B fusion and 9q deletion
Authors: Oliveira Jennifer L. , Kumar Riten , Khan Shakila P. , Law Mark E. , Erickson‐Johnson Michele , Oliveira Andre M. , Ketterling Rhett P. , Dogan Ahmet 
Published: November 2010

AbstractAcute bilineal leukemias are rare and are commonly associated with t(9;22) and MLL abnormalities. Herein, we report a pediatric case of bilineal T/myeloid acute leukemia associated with del (9q)(q13q22) and TLX3/BCL11B fusion due to the cryptic t(5;14)(q35;32). FISH studies confirmed the TLX3/BCL11B fusion in both the myeloid and lymphoid blasts, while the 9q deletion was restricted to the lymphoid component. Optimal therapy for such patients remains controversial and it is not clear if they should be treated with ALL or AML‐based chemotherapeutic regimens. Our patient has been in extended remission following ALL‐based chemotherapy and a matched unrelated cord blood transplant. Pediatr Blood Cancer 2011;56:467–469. © 2010 Wiley‐Liss, Inc.