bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tooth Tissue Loss in Locating Mesiobuccal Canal during Selective Retreatment using Dynamic Navigation System: An In vitro Study
Authors: Sajjan Girija S. , Suni Marampudi Suvarna , Mantena Satyanarayana Raju , Kinariwala Niraj , Koppera Niveditha , Satish R. Kalyan 
Published: June 2024

Selective root canal retreatment has demonstrated positive success, but the process is challenging because imprecision compromises the tooth's structural durability. As there is a lack of literature on selective retreatment using DNS, this in-vitro study was designed for comparative evaluation of tooth tissue loss and time taken in locating mesiobuccal (MB)canal using the dynamic navigation system (DNS; Navident, ClaroNav, Toronto, ON, Canada ) to the freehand (FH) method. The null hypothesis was that both methods would have similar tooth tissue loss and time required for the procedure. Twenty root canal-treated human mandibular molar teeth were mounted on Navident manikin. Using the Navident programme, the drilling path and depth were virtually designed using cone-beam computed tomographic (CBCT) scans. A minimal access cavity for locating the MB root was prepared with dynamic navigation in the DNS group and with freehand in the FH group. Volumetric tooth tissue loss was evaluated with the help of postoperative CBCT and On-demand software. Statistical analysis was done with an independent-sample T Test (p<0.05). The time taken for the procedure was recorded with a stopwatch. The tooth tissue loss was significantly less with the DNS group (35.83 mm3) compared to the FH group (52.84 mm3) with a P value of 0.001. The time taken for the DNS group was less with the DNS group (29.00 seconds) compared to the FH group (53.60 seconds) with statistical significance with a P value of 0.001. The DNS resulted in minimal tooth tissue loss with a shorter time compared to the FH group. This technique can be practised for predictable selective retreatment in endodontics.
Impact of female sex and type 2 diabetes mellitus on in-hospital mortality among patients with acute coronary syndrome: a retrospective cohort study between 2015-2022
Authors: Guzmán Quiroga Alejandra , Bustamante Cabrejo Alexander , Caballero-Alvarado José , Zavaleta-Corvera Carlos , Burgos Chávez Othoniel 
Published: June 2024

Aim. This study aimed to assess the influence of female sex and type 2 diabetes mellitus (T2DM) on in-hospital mortality among patients diagnosed with acute coronary syndrome (ACS) in the emergency department during the period 20152022, while also exploring the association of relevant laboratory factors.Material and methods. An observational, analytical, retrospective cohort study was conducted, focusing on patients diagnosed with acute coronary syndrome who had high-density lipoprotein (HDL) values measured. The study included a total of 196 patients, divided into diabetes and non-diabetes groups, totaling 98 patients in each.Results. Among the 196 patients with acute coronary syndrome, 181 survived, and 15 succumbed until hospital discharge. Statistically significant associations were identified between female sex (relative risk (RR): 3.52, 95% confidential interval (CI): 1.25-9.92, p=0.017) and T2DM (RR: 4.05, 95% CI: 1.51-10.85, p=0.005) withan increased risk of mortality in acute coronary syndrome patients. Notably, high HDL values did not exhibit a statistically significant association (RR: 0.88, 95% CI: 0.33-2.33, p=0.789). Subsequent multivariate analysis reaffirmed the significant association, indicating a 20% increased risk of death in patients with T2DM and acute coronary syndrome (RR: 1.2, 95% CI: 0.15-2.25, p=0.025).Conclusion. The study concludes that while elevated HDL levels are not associated with increased in-hospital mortality in acute coronary syndrome patients, T2DM emerges as a noteworthy factor influencing this outcome.
Levels of cardiac biomarkers and three-year survival rate in hospitalized patients with heart failure and community-acquired pneumonia
Authors: Podzolkov V. I. , Dragomiretskaya N. A. , Medvedev I. D. , Tolmacheva A. V. , Kosareva A. V. , Shvedov I. I. 
Published: June 2024

Aim. To evaluate the impact of community-acquired pneumonia (CAP) on the levels of cardiac biomarkers and long-term survival rate in patients with heart failure (HF).Material and methods. The prospective observational single-center study included 132 patients (73 men, 59 women); mean age — 72,3±12,1 years, consecutively hospitalized at Clinical Hospital № 4 of the I. M. Sechenov First Moscow State Medical University with decompensated heart failure in the period from March 2018 to December 2019. The main (n=40) and comparison group (n=92) included patients with and without clinical and CT signs of CAP, respectively.Results. Patients with HF and CAP and HF without CAP were comparable in sex, age, and severity of HF. CAP in most patients met the criteria for non-severe pneumonia (average CURB-65 score — 1,55±0,73). The levels of N-terminal probrain natriuretic peptide (NT-proBNP) in patients with HF with CAP (1188,9 [439; 2493] pg/ml) were insignificantly higher than in patients with HF without CAP (839,6 [413; 1900]) pg/ml (p>0,05). A similar pattern was noted for the soluble growth stimulation expressed gene 2 (sST2) (30,85 [12,8; 59,6] ng/ml vs 22,8 [15,2; 44,7] ng/ml, p>0,05). The haptoglobin level in patients with CAP was significantly lower (732 [315; 1312] ng/l), compared to the group without CAP (1270 [902; 2022] ng/l, p=0,0022). No differences in the concentrations of galectin-3, copeptin and hepcidin were detected. The one-year mortality rate of patients who underwent CAP was 27,3%, and without CAP — 7,2% (p<0,001), while the three-year mortality rate was 44,9% and 21,4%, respectively (p=0,0004). Elevated levels of NT-proBNP and sST2, along with age over 75 years and left ventricular ejection fraction <40%, are additional factors of poor prognosis in patients with HF and CAP.Conclusion. CAP in patients with HF does not have a significant effect on most cardiac biomarkers, but significantly worsens the prognosis. Independent factors of unfavorable prognosis in patients with HF and CAP are age over 75 years, left ventricular ejection fraction <40%, increased NT-proBNP and sST2 levels.
Relationship between left ventricular mechanical dyssynchrony and accelerated 99mTc-MIBI clearance in patients with heart failure
Authors: Mishkina A. I. , Atabekov T. A. , Sazonova S. I. , Agafonkin S. V. , Batalov R. E. , Zavadovsky K. V. 
Published: June 2024

Aim. To evaluate 99mTc-methoxy-isobutyl-isonitrile (99mTc-MIBI) washout rate and its relationship with contractility and left ventricular (LV) mechanical dyssynchrony in patients with heart failure (HF) of non-ischemic origin.Material and methods. The study included 20 patients with HF of non-ischemic origin with indications for cardiac resynchronization therapy (CRT). Ten patients without HF were included in the comparison group. All patients underwent 99mTc-MIBI myocardial perfusion scintigraphy (MPS). We assessed the 99mTc-MIBI washout rate, as well as LV perfusion, contractility, and mechanical dyssynchrony using phase analysis data (phase standard deviation, histogram bandwidth (HBW), asymmetry, and gradient). Six months after CRT, all patients with HF underwent MPS to assess the changes of studied parameters.Results. According to MPS, patients with HF had a higher 99mTc-MIBI washout rate from the LV myocardium compared with the comparison group (10,9 (8,49-13,8) vs 3,98 (0,9-9,8)%, p=0,0001), as well as severe LV mechanical dyssynchrony (standard deviation: 66 (55,11-73,24) vs 13,1 (10,1-19,6), p<0,0001; HBW: 207 (165-246) vs 40 (33-66), p<0,0001). The 99mTc-MIBI washout rate was positively correlated with LV end-diastolic (r=0,46, p<0,001) and LV end-systolic volumes (r=0,44, p<0,001) and negatively correlated with LV ejection fraction (r=0,41, p<0,001). A moderate correlation was found between the 99mTc-MIBI washout rate and following LV mechanical dyssynchrony and contractility parameters: HBW (r=0,412, p<0,001), asymmetry (r=-0,41, p<0,001), gradient (r=-0,44, p<0,001), wall motion (r=-0,45, p=0,001), wall thickening (r=-0,54, p<0,001). Six months after CRT, all patients showed a significant decrease in the 99mTc-MIBI washout rate from 12,4 (10,3-14,9) to 8,14 (3,37-8,88)%, p=0,0006.Conclusion. In patients with HF of non-ischemic origin, an increase in the 99mTc-MIBI washout rate from the LV myocardium is associated with the severity of impaired cardiac contractility and mechanical dyssynchrony.
Associations of cartilage intermediate layer protein 1 and hypoxia-inducible factor-1-alpha with transthoracic echocardiography results in patients with heart failure with preserved ejection fraction
Authors: Timofeev Yu. S. , Fokina Ju. A. , Metelskaya V. A. , Afaunova A. R. , Chernyshenko E. G. , Ivanova A. A. , Dzhioeva O. N. , Drapkina O. M. 
Published: June 2024

Aim. To evaluate the relationship of serum concentrations of myocardial remodeling and cellular hypoxia biomarkers cartilage intermediate layer protein 1 (CILP-1) and hypoxia-inducible factor-1-alpha (HIF-1α) with paraclinical parameters in patients with heart failure with preserved ejection fraction (HFpEF) and in the control group.Material and methods. The study included 47 patients diagnosed with HFpEF, aged from 47 to 79 years, who were treated from May 2018 to December 2019 in the hospital of the National Medical Research Center for Therapy and Preventive Medicine. The control group consisted of 32 people without a diagnosis of HFpEF, matched by sex and age. All participants underwent transthoracic echocardiography with assessment of diastolic function. Serum concentrations of CILP-1 and HIF-1α were determined by enzyme immunoassay using standardized test systems (RayBio and Clone-Cloud, USA).Results. In patients with HFpEF, the median serum concentrations of CILP-1 (3,24 ng/ml) and HIF-1α (14,3 pg/ml) were not significantly different from the values obtained in the control group (3,6 ng/ml and 7,5 pg/ml, respectively). Significant correlations of CILP-1 with echocardiographic indicators of the left ventricular interstitial fibrosis severity were revealed, while echocardiographic markers of HFpEF positively correlated with the HIF-1α level.Conclusion. Although the serum concentrations of CILP-1 and HIF-1α do not differ depending on HFpEF presence, it demonstrates an association with a number of echocardiographic parameters both in subgroups of patients with HFpEF and in subgroups of controls with different body mass index.
Total, ageand sex-specific mortality after discharge of patients with heart failure: the first large-scale cohort real-world study on Russian population
Authors: Soloveva A. E. , Medvedev A. E. , Lubkovsky A. V. , Shmakov A. I. , Solovev A. E. , Endubaeva G. V. , Gorbacheva T. V. , Vaulina O. Yu. , Alekseev P. S. , Kurilyuk Yu. E. , Villevalde S. V. , Zvartau N. E. , Shlyakhto E. V. 
Published: June 2024

Aim. To assess total, ageand sex-specific survival rate after discharge of patients with heart failure (HF) using real-world electronic health data.Material and methods. This retrospective analysis of data from the St. Petersburg Chronic Heart Failure Registry was performed. Hospitalizations of patients aged 18 years with a diagnosis code I50.x (International Classification of Diseases, 10th revision) were included in the period from January 1, 2019 to December 31, 2023. Cases with acute myocardial infarction, cerebrovascular accident, coronavirus disease 2019, hospitalization duration of >30 days, and death during the current hospitalization were not included.Results. The study included 73450 patients aged 18 to 99 years (mean age, 73±12 years; women, 59,1%). During a median follow-up of 388 days, 16212 (22,1%) patients died. The cumulative death probability within one and five years after discharge was 16,3% and 48,9%. At each time period, the rate was higher in men when stratified by age and as age increased.The mortality rate was 15,3 (95% confidence interval 15,1 to 15,6) per 100 patientyears. For all subgroups, the highest value was recorded in the first month after discharge (50,1 per 100 patient-years), reaching a maximum in the subgroup of elderly and senile patients (60,7 per 100 patient-years).Conclusion. Within 1 year and 5 years after hospital discharge, 16,3% and 48,9% of patients with HF die, respectively. The highest death risk is typical in the first month after discharge, especially for elderly and senile patients.
Long-term effects of enhanced external counterpulsation in the management of patients with coronary artery disease complicated by heart failure: data from the EXCEL study
Authors: Lishuta A. S. , Slepova O. A. , Nikolaeva N. S. , Privalova E. V. , Belenkov Yu. N. 
Published: June 2024

Aim. To study the long-term effect of complex therapy with enhanced external counterpulsation (EECP) on exercise tolerance, quality of life, and systolic cardiac function in patients with stable coronary artery disease (CAD) complicated by heart failure (HF).Material and methods. Open randomized study EXCEL (NCT05913778) included 118 patients with verified stable CAD complicated by NYHA class II-III HF with reduced or mildly reduced ejection fraction (EF). The patients were randomized into group 1 (n=59) who received optimal therapy and EECP (35 hours, 2 courses per year) or group 2 (n=59), who recived optimal drug therapy and EECP (35 hours, 1 course per year). All patients underwent a 6-minute walk test (6MWT) at baseline, 12, 24 and 36 months, the assessment of clinical status, Minnesota Living with Heart Failure Questionnaire (MLHFQ), N-terminal pro-brain natriuretic peptide (NTproBNP) levels, LVEF and clinical outcomes.Results. In both groups, we revealed an improvement of HF class (average HF class after 36 months decreased in the 1st group from 2,40 to 1,86 (p<0,001), and in the 2nd group from 2,37 to 2,17 (p<0,001)) and clinical status of patients. A significant increase in 6MWT distance after 24 months was revealed in both groups — in group 1 by 59,4% (95% confidence interval (CI) 36,9-76,8), and in group 2 — by 34,3% (95% CI 26,7-40,1). The proportions of patients with an increase in 6MWD distance >20% in groups 1 and 2 after 36 months were 100% (n=59) and 79,7% (n=47) (p<0,001), respectively. There was a significant decrease in the MLHFQ score after 36 months in the 1st group by 43,8% (95% CI 40,5-47,1), and in the 2nd group by 30,0% (95% CI 26,4-33,6), NT-proBNP decrease, as well as an increase in LVEF. There were no deaths in group 1, while in group 2, mortality was 3,4%.Conclusion. A 36-month follow-up of patients with CAD complicated by HF receiving EECP revealed stable improvements in exercise tolerance, quality of life, systolic cardiac function, more pronounced in the group with 2 courses of EECP per year, as well as a decrease in the incidence of adverse outcomes.
Принципы права: проблемы применения
Authors: Velichinskaya Yuliya 
Published: June 2024

Федеральный закон от 31 июля 2020 г . № 247-ФЗ «Об обязательных требованиях в Российской Федерации» (далее — Федеральный закон № 247-ФЗ) определяет правила «лучшего регулирования» экономических отношений . В законе проводится идея замкнутого регуляторного цикла с включением общественности в процессы разработки и оценки действия нормативных правовых актов, а также определены принципы, которые должны применяться в рамках этих процессов (принципы установления и оценки применения обязательных требований) . Принципы права в статье рассматриваются на примере принципов, предусмотренных Федеральным законом № 247-ФЗ . Содержание указанных принципов дает основание полагать, что они имеют конституционно-правовую природу, которая раскрывается в решениях Конституционного Суда Российской Федерации . Автор предполагает, что содержание принципов установления и оценки применения обязательных требований шире, чем буквально сформулировано в Федеральном законе № 247-ФЗ, и на практике может быть дополнено позициями Суда . В связи с этим цель данной статьи — продемонстрировать конституционно-правовой характер принципов Федерального закона № 247-ФЗ, более полно раскрыть их содержание и возможное применение . Автор показывает, что принципы законности, обоснованности обязательных требований, исполнимости обязательных требований развивают конституционные принципы соразмерности и пропорциональности ограничений прав и свобод, баланса частных и публичных интересов, формируя тест на пропорциональность и соразмерность ограничений, порождаемых обязательными требованиями . Принципы правовой определенности и системности, открытости и предсказуемости основываются на принципе поддержания доверия к действиям государства, вытекающем из конституционных принципов юридического равенства и справедливости в правовом демократическом государстве . При рассмотрении принципов сделан акцент на их регуляторном потенциале и проблемах реализации, в том числе затронут ряд вопросов проведения оценки регулирующего воздействия и оценки применения обязательных требований . Также в статье исследуется правовое содержание основных понятий Федерального закона № 247-ФЗ: обязательные требования, охраняемые законом ценности, риск причинения вреда (ущерба) охраняемым законом ценностям .Для цитирования: Величинская Ю.Н. Принципы права: проблемы применения// Право. Журнал Высшей школы экономики. 2022. T.15. N 1. С. 180–207. DOI: 10.17323/2072- 8166.2022.1.180.207.
A High-Precision Earthquake Catalog for Nevada
Authors: Trugman Daniel T. 
Published: June 2024

Abstract
The state of Nevada is home to one of the most seismically active regions in the world, with crustal deformation associated with the Walker Lane transitioning into Basin and Range tectonics as one traverses from west to east across the state. Despite hosting numerous prominent earthquake sequences over the past century and beyond, at present, there exists no unified research-quality earthquake catalog for the state and its surrounding region. Here, we present a newly compiled, high-precision catalog of more than 180,000 earthquakes occurring around Nevada from 2008 to 2023. The data processing workflow to create this catalog includes an absolute location step that accounts for topography and 3D variations in subsurface wavespeed, and a relative relocation step that refines event positions using differential times measured from waveform cross-correlation. We also provide an update to the local magnitude scale that better accounts for the observed distance attenuation of waveform amplitudes as well as local site effects. We describe some fundamental insights that can be derived from the new catalog, including regional variations in event depth distributions and sequence clustering statistics, and publish the catalog to the wider community to facilitate future research efforts.
Russian versions of FADI and FAAM for preoperative and postoperative assessment of the foot function
Authors: Akulaev A. A. , Ivanov A. A. , Ionova T. I. , Nikitina T. P. , Tishchenkov K. A. , Povaliy A. A. 
Published: June 2024

Introduction Self-administered questionnaire recommended by international orthopaedic community is a practical instrument for use in pathological conditions related to the foot and ankle.The objective was to validate the Russian-language versions of the FADI and FAAM questionnaires to be filled out by orthopaedic patients with forefoot disorders before and after surgical treatment.Material and methods The study included 100 adult patients with forefoot disorders to be surgically treated. The average age of the patients was 52 ± 12.1 years with 97 % being females and 26 % being athletes. The patients completed the FADI and FAAM questionnaires preoperatively and at 2 months after surgery and they were requested to fill out the SF-36 questionnaire and the LEFS scale preoperatively.Results The Cronbach's α value was 0.91 for activities of daily living and 0.94 for sports measured with both questionnaires. The reproducibility of the questionnaires was demonstrated by high ICC values (≥ 0.992) and no changes (ES < 0.01) in stable patients. Satisfactory construct validity was confirmed by significant correlations in activities of daily living and sports activities; criterion validity was confirmed by the dorsiflexion angle in the MCP1 and the daily (p < 0.001) and sports activities (p < 0.05). Convergent validity of the FADI and FAAM was identified with correlations measured with SF-36 and LEFS. Patients with moderate/severe impairment in range of motion had worse functional status scored with the FADI and FAAM as compared with those who had no/mild impairment. A significant improvement was seen postoperatively in non-athletes (p < 0.001). Sports activity significantly improved postoperatively in athletes (p < 0.05).Discussion A limitation of the study includes the sample consisting mostly of patients with one type of orthopaedic pathology (valgus foot). Another limitation is that the majority of patients were females, and the patients were treated in the same health care facility. We can conclude that in the future it would be advisable to test the Russian versions of the FADI and FAAM questionnaires in patients with other foot pathologies and to conduct multicenter studies using these questionnaires.Conclusion The FADI and FAAM scores measured in the Russian population showed greater sensitivity to changes in the foot/ankle joint in individuals who had indications for surgical treatment for a foot condition.
Ankle joint replacement for necrosis of the talus, crusarthrosis, equinovarus and adducted foot
Authors: Kuznetsov V. V. , Protsko V. G. , Tamoev S. K. , Osnach S. A. , Mazalov A. V. , Platonov V. V. 
Published: June 2024

Introduction Surgical treatment of patients with avascular osteonecrosis of the talus and post-traumatic hindfoot deformity is associated with high morbidity, difficulty of early disease detection, the discrepancy between patient expectations and orthopaedic requirements for surgical outcomes due to traditional methods. The use of customized ankle joint replacement may be a potential solution to this problem.The objective was to evaluate the results of treatment of a patient with avascular osteonecrosis of the talus, crusarthrosis and hindfoot deformity using an original replacement method for the ankle joint and the talus.Material and methods A 30-year-old patient with post-traumatic avascular osteonecrosis of the talus, crusarthrosis, equinovarus and adducted foot underwent replacement of the ankle joint and talus using the method developed by the authors. Radiographic and tomographic methods were used for diagnosis. The VAS scale, AOFAS, FFI, EFAS questionnaires and pedobarography were used to assess clinical and functional results.Results The results of treatment evaluated at 12 months showed maintained foot deformity correction, stability of a tailored construct with no signs of loosening and osteolysis. The clinical and functional result showed a 81/2 VAS decrease in pain, functional status improved by 4.3 times with functional foot index (FFI) improved by 2.2 times according to the AOFAS scale at 12 months.Discussion Orthopaedic surgeons are conducting research aimed at preserving ankle motion in the treatment of avascular osteonecrosis of the talus. A serious problem is associated with concomitant deformities of the hindfoot and available implants fail to solve this problem.Conclusion The surgical method offered for the patient provided good clinical and functional results with the hindfoot deformity corrected within one stage reducing the treatment time.