bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physicochemical Characterization, Antioxidant and Tyrosinase Inhibitory Activities of Coffea Robusta Monofloral Honey from Dak Lak Province, Vietnam
Authors: Nguyen Quang‐Vinh , Nguyen Minh‐Trung , Thi Bich Huyen Bui , Mai Quoc‐Quan , Doan Manh‐Dung , Nguyen Thi‐Huyen , Nguyen Phuoc‐Vinh , Pham Tri‐Nhut , Le Tam Minh 
Published: May 2024

AbstractRobusta coffee blossom honey stands as a key regional product in Dak Lak province, Vietnam. Despite its significance, there exists a dearth of scientific data for assessing its quality. This study aims to fill this gap by characterizing the physicochemical properties and biological activities of coffee blossom honeys from three distinct sub‐regions within Dak Lak province, Vietnam. These activities include ferric reducing power (FRP), DPPH and ABTS radical scavenging, as well as tyrosinase inhibitory activities. Moreover, the study compares these honey samples with other popular varieties in Vietnam, such as Lychee and Longan honeys. The physicochemical parameters of the honey samples meet the standards set by Codex Alimentarius 2001. Through UPLC analysis, eleven compounds were identified, with caffeine serving as a marker for coffee honey. Furthermore, by employing multiple factor analysis (MFA), it was observed that certain physicochemical properties correlate positively with tyrosinase inhibitory, DPPH, ABTS free radicals scavenging activities, and FRP. Notably, tyrosinase inhibitory activity exhibited a positive correlation with antioxidant activity. These findings underscore the high quality of Coffea robusta honey, showcasing its potent antioxidant and tyrosinase inhibitory activities.
Oliveria decumbens, a Long‐Neglected Plant with Promising Phytochemical and Biological Properties
Authors: Boveiri Dehsheikh Anahita , Mahmoodi Sourestani Mohammad , Enayatizamir Naeimeh , Safdarian Mehdi , Mottaghipisheh Javad 
Published: May 2024

AbstractOliveria decumbens is a folkloric medicinal plant belonging to the Apiaceae family, traditionally utilized to treat various diseases like gastrointestinal disorders, fever, and wounds. This review aims to provide a comprehensive overview of the plant‘s phytochemical composition and biological properties, with potential implications for various industries and avenues of further research. The data presented here has been compiled through searches utilizing the keyword “Oliveria” across scientific databases such as PubMed, Web of Science, Scopus, ScienceDirect, and SciFinder. Carvacrol and thymol have been identified as the primary volatile constituents, though the complete profile of the plant extract remains to be fully elucidated. Notably, Oliveria decumbens essential oil exhibits significant antibacterial, antifungal, antioxidant, and anticancer properties. Additionally, the plant extract demonstrates promising antiprotozoal, antiviral, hepatoprotective, and immunostimulant effects, although these findings are primarily derived from preliminary studies. While in vitro and in vivo investigations have validated some traditional uses of O. decumbens, further pre‐clinical testing is warranted to ascertain both efficacy and safety profiles. Moreover, the identification of specific components within the plant extract is crucial for a more comprehensive understanding of the mechanisms of action underlying its therapeutic properties within the realm of phytomedicine.
Chemical and Enzyme‐Mediated Chemical Reactions for Studying Nucleic Acids and Their Modifications
Authors: Li Tengwei , Cheng Chongguang , Liu Jianzhao 
Published: May 2024

AbstractNucleic acids are genetic information‐carrying molecules inside cells. Apart from basic nucleotide building blocks, there exist various naturally occurring chemical modifications on nucleobase and ribose moieties, which greatly increase the encoding complexity of nuclei acids, contribute to the alteration of nucleic acid structures, and play versatile regulation roles in gene expression. To study the functions of certain nucleic acids in various biological contexts, robust tools to specifically label and identify these macromolecules and their modifications, and to illuminate their structures are highly necessary. In this review, we summarize recent technique advances of using chemical and enzyme‐mediated chemical reactions to study nucleic acids and their modifications and structures. By highlighting the chemical principles of these techniques, we aim to present a perspective on the advancement of the field as well as to offer insights into developing specific chemical reactions and precise enzyme catalysis utilized for nucleic acids and their modifications.
DNA Aptamer Integrated Hydrogel Nanocomposites on Screen Printed Gold Electrodes for Point‐of‐Care Detection of Testosterone in Human Serum
Authors: Velayutham Jayasudha , Hansda Shekhar , Sethy Niroj K , Vashist Arti , Manickam Pandiaraj 
Published: May 2024

AbstractThis work describes the development and evaluation of a novel electrochemical aptasensor for testosterone detection. The sensor utilizes a specifically designed DNA immobilized on a screen‐printed gold electrode (SPGE) modified with a conductive hydrogel and gold nanoparticles (HG/NP) composite. The aptasensor exhibited a dose‐dependent response to testosterone (0.05 to 50 ng/mL) with a detection limit of 0.14 ng/mL and a good sensitivity of 0.23 μA ng−1 mL cm−2. The sensor displayed excellent selectivity towards testosterone compared to structurally similar steroid hormones. Importantly, the incorporation of HG/NP not only improved the sensor‘s conductivity but also acted as an antifouling layer, minimizing signal interference from non‐specific biomolecule interactions in complex biological samples like human serum. The results obtained from the aptasensor showed good correlation with a standard ELISA method, demonstrating its effectiveness in real‐world scenarios.
Enantioselective Construction of Polycyclic Chromanes through Organocatalytic Sequential Quintuple Reaction via One‐Pot Step‐Wise Procedure
Authors: Wang Jie , Qin Hang , Song Ya‐Li , Cao Fei , You Zhi‐Hao 
Published: May 2024

Comprehensive SummaryAn efficient and highly stereoselective synthetic method to access polycyclic chromanes has been achieved through organocatalyzed one‐pot step‐wise reactions involving 2‐hydroxycinnamaldehydes, 2‐aminochalcones, and malononitrile as substrates. The reactions underwent a quintuple process by aza‐Michael/Michael/Knoevenagel/oxa‐Michael/aldol‐type reaction in sequence to give products bearing 3 new generated rings and 5 chiral centers in moderate to quantitative yields with excellent stereoselectivities. A novel retro‐reaction mechanism was discovered in the synthetic transformations of products.
Low‐Molecular Weight Branched Polyethylenimine Reduces Cytokine Secretion from Human Immune System Monocytes Stimulated with Bacterial and Fungal PAMPs
Authors: Heydarian Neda , Ferrell Maya , Nair Ayesha S. , Roedl Chase , Peng Zongkai , Nguyen Tra D. , Best William , Wozniak Karen L. , Rice Charles V. 
Published: May 2024

AbstractThe innate immune system is an evolutionarily conserved pathogen recognition mechanism that serves as the first line of defense against tissue damage or pathogen invasion. Unlike the adaptive immunity that recruits T‐cells and specific antibodies against antigens, innate immune cells express pathogen recognition receptors (PRRs) that can detect various pathogen‐associated molecular patterns (PAMPs) released by invading pathogens. Microbial molecular patterns, such as lipopolysaccharide (LPS) from Gram‐negative bacteria, trigger signaling cascades in the host that result in the production of pro‐inflammatory cytokines. LPS stimulation produces a strong immune response and excessive LPS signaling leads to dysregulation of the immune response. However, dysregulated inflammatory response during wound healing often results in chronic non‐healing wounds that are difficult to control. In this work, we present data demonstrating partial neutralization of anionic LPS molecules using cationic branched polyethylenimine (BPEI). The anionic sites on the LPS molecules from Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) are the lipid A moiety and BPEI binding create steric factors that hinder the binding of PRR signaling co‐factors. This reduces the production of pro‐inflammatory TNF‐α cytokines. However, the anionic sites of Pseudomonas aeruginosa (P. aeruginosa) LPS are in the O‐antigen region and subsequent BPEI binding slightly reduces TNF‐α cytokine production. Fortunately, BPEI can reduce TNF‐α cytokine expression in response to stimulation by intact P. aeruginosa bacterial cells and fungal zymosan PAMPs. Thus low‐molecular weight (600 Da) BPEI may be able to counter dysregulated inflammation in chronic wounds and promote successful repair following tissue injury.
Effect of Carbamazepine on the Pharmacokinetics of Erdafitinib in Healthy Participants
Authors: Jaiprasart Pharavee , Hellemans Peter , Jiao Juhui James , Dosne Anne‐Gaëlle , De Meulder Marc , De Zwart Loeckie , Brees Laurane , Zhu Wei 
Published: May 2024

AbstractErdafitinib, a selective and potent oral pan‐FGFR inhibitor, is metabolized mainly through CYP2C9 and CYP3A4 enzymes. This phase 1, open‐label, single‐sequence, drug‐drug interaction study evaluated the pharmacokinetics, safety, and tolerability of a single oral dose of erdafitinib alone and when co‐administered with steady state oral carbamazepine, a dual inducer of CYP3A4 and CYP2C9, in 13 healthy adult participants (NCT04330248). Compared with erdafitinib administration alone, carbamazepine co‐administration decreased total and free maximum plasma concentrations of erdafitinib (Cmax) by 35% (95% CI 30%‐39%) and 22% (95% CI 17%‐27%), respectively. The areas under the concentration‐time curve over the time interval from 0 to 168 hours, to the last quantifiable data point, and to time infinity (AUC168h, AUClast, AUCinf), were markedly decreased for both total erdafitinib (56%‐62%) and free erdafitinib (48%‐55%). The safety profile of erdafitinib was consistent with previous clinical studies in healthy participants, with no new safety concerns when administered with or without carbamazepine. Co‐administration with carbamazepine may reduce the activity of erdafitinib due to reduced exposure. Concomitant use of strong CYP3A4 inducers with erdafitinib should be avoided.
Tuning Electronic and Structural Properties of Lead‐Free Metal Halide Perovskites: A Comparative Study of 2D Ruddlesden‐Popper and 3D Compositions
Authors: Dalmedico J. F. , Silveira D. N. , O. de Araujo L. , Wenzel W. , Rêgo C. R. C. , Dias A. C. , Guedes‐Sobrinho D. , Piotrowski Maurício J. 
Published: May 2024

AbstractIn recent decades, two‐dimensional (2D) perovskites have emerged as promising semiconductors for next‐generation photovoltaics, showing notable advancements in solar energy conversion. Herein, we explore the impact of alternative inorganic lattice BX‐based compositions (B=Ge or Sn, X=Br or I) on the energy gap and stability. Our investigation encompasses BA2Man‐1BnX3n+1 2D Ruddlesden‐Popper perovskites (for n=1–5 layers) and 3D bulk (MA)BX3 systems, employing first‐principles calculations with spin‐orbit coupling (SOC), DFT‐1/2 quasiparticle, and D3 dispersion corrections. The study unveils how atoms with smaller ionic radii induce anisotropic internal and external distortions within the inorganic and organic lattices. Introducing the spacers in the low‐layer regime reduces local distortions but widens band gaps. Our calculation protocol provides deeper insights into the physics and chemistry underlying 2D perovskite materials, paving the way for optimizing environmentally friendly alternatives that can efficiently replace with sustainable materials.
Changing overwork culture: Stakeholder management for employee wellbeing and social sustainability in large Japanese companies
Authors: Kobayashi Kazunori , Eweje Gabriel , Tappin David 
Published: May 2024

AbstractEffectively addressing overwork culture in business remains a challenge, despite growing concerns about its negative impacts on employee wellbeing and productivity. This paper investigates corporate social responsibility (CSR) initiatives and stakeholder management promoted by large Japanese companies to address overwork culture. Based on interviews with managers and stakeholders from 31 companies, the study reveals that despite being part of CSR, overwork reduction initiatives often come into conflict with entrenched institutional pressures. These pressures are embedded in a cultural‐cognitive and institutional context that prioritises quality and cooperation over individual productivity. We argue that improving stakeholder relationships is vital for developing a healthy and productive workstyle and for reactivating institutional dynamics that are fundamental to employee wellbeing, productivity and broader social sustainability. By clarifying the role and processes of stakeholder management, this paper contributes to the discourse on overwork and CSR, offering new insights into how to effectively address overwork culture.
Biomass Source Influence on Hydrogen Production through Pyrolysis and in Line Oxidative Steam Reforming
Authors: Garcia Irati , Lopez Gartzen , Santamaria Laura , Fernandez Enara , Bilbao Javier , Olazar Martin , Artetxe Maite , Amutio Maider 
Published: May 2024

AbstractThis study evaluates the potential of several biomasses differing in nature and composition for their valorization by pyrolysis and in line oxidative steam reforming. The first task involved the fast pyrolysis of the biomasses in a conical spouted bed reactor (CSBR) at 500 °C, in which product yields were analyzed in detail. Then, the oxidative steam reforming (OSR) of pyrolysis volatiles (gases and bio‐oil) was approached in a fluidized bed reactor (FBR). The reforming experiments were performed at 600 °C, with a steam/biomass (S/B) ratio of 3 and catalyst (Ni/Al2O3) space times of 7.5 and 20 gcat min gvol−1. Concerning equivalence ratio (ER), a value of 0.12 was selected to ensure autothermal operation. Remarkable differences were observed in H2 production depending on the type of biomass. Thus, pine wood led to a H2 production of 9.3 wt %. The lower productions obtained with rice husk (7.7 wt %) and orange peel (5.5 wt %) are associated with their higher ash and fixed carbon content, respectively, which limit the efficiency of biomass conversion to bio‐oil. However, in the case of the microalgae, the poor performance observed is because of the lower conversion in the reforming step toward gases due to the composition of its pyrolysis volatile stream.
An efficient routing protocol to reduce traffic and congestion control in cloud edge networks of wireless sensor networks
Authors: Alwarsamy Vijayaraj , Rethnaraj Jebakumar , Gurumuni Nathan Uma Devi , Pandiarajan Gururama Senthilvel 
Published: May 2024

SummaryRecently, wireless sensor networks (WSNs) have been used for monitoring, sensing, processing, and communication purposes in real‐time applications. It is employed with a routing protocol that performs an effective data transmission process. However, while transmitting large data, there occurs an over fitting issue, which leads to determining a huge data leakage. Also, the delay is increased with heavy congestion in the network. Hence, a novel method is proposed to diminish the network congestion regarding distributed networks as well as cloud edge computing. Moreover, it diminished the data loss from an overloaded condition. However, the proposed technique controls congestion that resists the traffic in the network through lightweight, ultra‐dense label‐less federation and incorporates adaptive multi‐agent Markov reinforcement learning. Furthermore, a distributed energy‐efficient delay‐aware routing protocol is employed to analyze and regulate congestion control in the network. Also, it varies the network dynamically by adjusting the routing protocol that optimizes the congestion and implements the traffic mechanism. Moreover, the congestion in WSNs overwhelms the nodes and channels distributed in the packets. The evaluation of the proposed method is determined by various metrics such as queuing delay, network lifetime, energy efficiency, throughput, and packet delivery ratio. The experimental results revealed that the proposed method attained an enhanced performance by maximizing energy efficiency and packet delivery ratio by 94% as well as 89% and reducing the delay by 55%, respectively.
Recent advancements in image‐enhanced endoscopy in the pancreatobiliary field
Authors: Toyonaga Haruka , Hayashi Tsuyoshi , Hama Kazuki , Ando Ryo , Ishii Tatsuya , Yoshida Kenta , Kin Toshifumi , Motoya Masayo , Takahashi Kuniyuki , Katanuma Akio 
Published: May 2024

AbstractImage‐enhanced endoscopy (IEE) has advanced gastrointestinal disease diagnosis and treatment. Traditional white‐light imaging has limitations in detecting all gastrointestinal diseases, prompting the development of IEE. In this review, we explore the utility of IEE, including texture and color enhancement imaging and red dichromatic imaging, in pancreatobiliary (PB) diseases. IEE includes methods such as chromoendoscopy, optical‐digital, and digital methods. Chromoendoscopy, using dyes such as indigo carmine, aids in delineating lesions and structures, including pancreato‐/cholangio‐jejunal anastomoses. Optical‐digital methods such as narrow‐band imaging enhance mucosal details and vessel patterns, aiding in ampullary tumor evaluation and peroral cholangioscopy. Moreover, red dichromatic imaging with its specific color allocation, improves the visibility of thick blood vessels in deeper tissues and enhances bleeding points with different colors and see‐through effects, proving beneficial in managing bleeding complications post‐endoscopic sphincterotomy. Color enhancement imaging, a novel digital method, enhances tissue texture, brightness, and color, improving visualization of PB structures, such as PB orifices, anastomotic sites, ampullary tumors, and intraductal PB lesions. Advancements in IEE hold substantial potential in improving the accuracy of PB disease diagnosis and treatment. These innovative techniques offer advantages paving the way for enhanced clinical management of PB diseases. Further research is warranted to establish their standard clinical utility and explore new frontiers in PB disease management.
Skimming genomes for systematics and DNA barcodes of corals
Authors: Quattrini Andrea M. , McCartin Luke J. , Easton Erin E. , Horowitz Jeremy , Wirshing Herman H. , Bowers Hailey , Mitchell Kenneth , González‐García María del P. , Sei Makiri , McFadden Catherine S. , Herrera Santiago 
Published: May 2024

AbstractNumerous genomic methods developed over the past two decades have enabled the discovery and extraction of orthologous loci to help resolve phylogenetic relationships across various taxa and scales. Genome skimming (or low‐coverage genome sequencing) is a promising method to not only extract high‐copy loci but also 100s to 1000s of phylogenetically informative nuclear loci (e.g., ultraconserved elements [UCEs] and exons) from contemporary and museum samples. The subphylum Anthozoa, including important ecosystem engineers (e.g., stony corals, black corals, anemones, and octocorals) in the marine environment, is in critical need of phylogenetic resolution and thus might benefit from a genome‐skimming approach. We conducted genome skimming on 242 anthozoan corals collected from 1886 to 2022. Using existing target‐capture baitsets, we bioinformatically obtained UCEs and exons from the genome‐skimming data and incorporated them with data from previously published target‐capture studies. The mean number of UCE and exon loci extracted from the genome skimming data was 1837 ± 662 SD for octocorals and 1379 ± 476 SD loci for hexacorals. Phylogenetic relationships were well resolved within each class. A mean of 1422 ± 720 loci was obtained from the historical specimens, with 1253 loci recovered from the oldest specimen collected in 1886. We also obtained partial to whole mitogenomes and nuclear rRNA genes from >95% of samples. Bioinformatically pulling UCEs, exons, mitochondrial genomes, and nuclear rRNA genes from genome skimming data is a viable and low‐cost option for phylogenetic studies. This approach can be used to review and support taxonomic revisions and reconstruct evolutionary histories, including historical museum and type specimens.
Influences of elevational gradient on flower size and number of Gentiana lawrencei var. farreri
Authors: Wang Mengyan , Wang Zuoyi , Yang Yuan , Zhao Xinquan , Zhou Huakun , Zhou Shurong , Yin Xin , Ren Yanmei , Dong Huanhuan , Zhang Longxin , Ma Zhen , Zhang Chunhui 
Published: May 2024

AbstractPlants can adapt to environmental changes by adjusting their functional traits and biomass allocation. The size and number of flowers are functional traits related to plant reproduction. Life history theory predicts that there is a trade‐off between flower size and number, and the trade‐off can potentially explain the adaptability of plants. Elevation gradients in mountains provide a unique opportunity to test how plants will respond to climate change. In this study, we tried to better explain the adaptability of the alpine plant Gentiana lawrencei var. farreri in response to climate change. We measured the flower size and number, individual size, and reproductive allocation of G. lawrencei var. farreri during the flowering period along an elevation gradient from 3200 to 4000 m, and explored their relationships using linear mixed‐effect models and the structural equation model. We found that with elevation increasing, individual size and flower number decreased and flower size increased, while reproductive allocation remained unchanged. Individual size positively affected flower number, but was not related to flower size; reproductive allocation positively affected flower size, but was not related to flower number; there is a clear trade‐off between flower size and number. We also found that elevation decreased flower number indirectly via directly reducing individual size. In sum, this study suggests that G. lawrencei var. farreri can adapt to alpine environments by the synergies or trade‐offs among individual size, reproductive allocation, flower size, and flower number. This study increases our understanding of the adaptation mechanisms of alpine plants to climate change in alpine environments.
Applying natural language processing to identify emergency department and observation encounters for worsening heart failure
Authors: Hamilton Steven A. , Ambrosy Andrew P. , Parikh Rishi V. , Tan Thida C. , Fitzpatrick Jesse K. , Avula Harshith R. , Sandhu Alexander T. , Ku Ivy A. , Go Alan S. , Sax Dana , Bhatt Ankeet S. 
Published: May 2024

AbstractAimsWorsening heart failure (WHF) events occurring in non‐inpatient settings are becoming increasingly recognized, with implications for prognostication. We evaluate the performance of a natural language processing (NLP)‐based approach compared with traditional diagnostic coding for non‐inpatient clinical encounters and left ventricular ejection fraction (LVEF).Methods and resultsWe compared characteristics for encounters that did vs. did not meet WHF criteria, stratified by care setting [i.e. emergency department (ED) and observation stay]. Overall, 8407 (22%) encounters met NLP‐based criteria for WHF (3909 ED visits and 4498 observation stays). The use of an NLP‐derived definition adjudicated 3983 (12%) of non‐primary HF diagnoses as meeting consensus definitions for WHF. The most common diagnosis indicated in these encounters was dyspnoea. Results were primarily driven by observation stays, in which 2205 (23%) encounters with a secondary HF diagnosis met the WHF definition by NLP.ConclusionsThe use of standard claims‐based adjudication for primary diagnosis in the non‐inpatient setting may lead to misclassification of WHF events in the ED and overestimate observation stays. Primary diagnoses alone may underestimate the burden of WHF in non‐hospitalized settings.