bluuebunny/crossref_metadata_2025_split huggingface dataset:
A DFTB study on the electronic response of encapsulated DNA nucleobases onto chiral CNTs as a sequencer
Authors: Monavari Seyyed Mostafa , Memarian Nafiseh 
Published: May 2024

AbstractSequencing the DNA nucleobases is essential in the diagnosis and treatment of many diseases related to human genes. In this article, the encapsulation of DNA nucleobases with some of the important synthesized chiral (7, 6), (8, 6), and (10, 8) carbon nanotubes were investigated. The structures were modeled by applying density functional theory based on tight binding method (DFTB) by considering semi-empirical basis sets. Encapsulating DNA nucleobases on the inside of CNTs caused changes in the electronic properties of the selected chiral CNTs. The results confirmed that van der Waals (vdW) interactions, π-orbitals interactions, non-bonded electron pairs, and the presence of high electronegative atoms are the key factors for these changes. The result of electronic parameters showed that among the CNTs, CNT (8, 6) is a suitable choice in sequencing guanine (G) and cytosine (C) DNA nucleobases. However, they are not able to sequence adenine (A) and thymine (T). According to the band gap energy engineering approach and absorption energy, the presence of G and C DNA nucleobases decreased the band gap energy of CNTs. Hence selected CNTs suggested as biosensor substrates for sequencing G and C DNA nucleobases.
Effect of nano-graphene lubricating oil on particulate matter of a diesel engine
Authors: Kuang Xin , Yang Xiping , Fu Hao , Li Shengyong , Bian Hua 
Published: May 2024

AbstractNano-graphene lubricating oil with appropriate concentration shows excellent performance in reducing friction and wear under different working conditions of diesel engines, and has been widely concerned. Lubricating oil has a significant impact on particulate matter (PM) emissions. At present, there are few studies on the impact of nano-graphene lubricating oil on the physicochemical properties of PM. In order to comprehensively evaluate the impact of nano-graphene lubricating oil on diesel engines, this paper mainly focused on the effects of lubricating oil nano-graphene additives on the particle size distribution and physicochemical properties of PM. The results show that, compared with pure lubricating oil, the total number of nuclear PM and accumulated PM of nano-graphene lubricating oil is significantly increased. The fractal dimension of PM of nano-graphene lubricating oil increases and its structure becomes more compact. The average fringe separation distance of basic carbon particles decreases, the average fringe length increases. The degree of ordering and graphitization of basic carbon particles are higher. The fringe tortuosity of basic carbon particles decreases, and the fluctuation of carbon layer structure of basic carbon particles decreases. Aliphatic substances in PM are basically unchanged, aromatic components and oxygen functional groups increase. The initial PM oxidation temperature and burnout temperature increase, the maximum oxidation rate temperature and combustion characteristic index decrease, and the activation energy increases, making it more difficult to oxidize. This was mainly caused by the higher graphitization degree of PM of nano-graphene lubricating oil and the increased content of aromatic substances.
Association of hepatic steatosis and liver fibrosis with chronic obstructive pulmonary disease among adults
Authors: Zheng Dayang , Liu Xiang , Zeng Wei , Zhou Wangyan , Zhou Chunxiang 
Published: May 2024

AbstractWith high prevalence and substantial mortality, metabolic dysfunction-associated steatotic liver disease and chronic obstructive pulmonary disease (COPD) are significant public health concerns. Utilizing a large, population-based dataset from the National Health and Nutrition Examination Survey, our study probes the relationship between COPD prevalence and hepatic steatosis and fibrosis, as measured by Vibration-Controlled Transient Elastography. We analyzed data from 693 individuals with COPD and 7229 without. Through weighted multivariate logistic regression analysis, a restricted cubic spline curve, and threshold effect analysis, we investigated the correlation between the severity of hepatic steatosis and fibrosis and the presence of COPD. Our findings revealed a positive correlation between the controlled attenuation parameter (CAP) and COPD prevalence [OR = 1.03 (95% CI 1.01, 1.05)], even after multivariate adjustment. Furthermore, we observed a U-shaped association between CAP and COPD, where the inflection point, CAP value of 264.85 dB/m, corresponded to the lowest COPD prevalence. Our study emphasizes a substantial and complex link between hepatic steatosis and COPD. These findings urge healthcare professionals to factor liver health into COPD management and prompt further exploration into the underlying mechanisms. This could pave the way for the development of improved prevention and treatment strategies.
Conservation units alone are insufficient to protect Brazilian Amazonian chelonians
Authors: Sousa Loyriane Moura , Correia Letícia Lima , Alexandre Rafaela Jemely Rodrigues , Pena Simone Almeida , Vieira Thiago Bernardi 
Published: May 2024

AbstractThe creation of protected areas (PAs) is not always based on science; consequently, some aquatic species may not receive the same level of protection as terrestrial ones. The objective of this study was to identify priority areas for the conservation of chelonians in the Brazilian Amazon basin and assess the contribution of PAs, distinguishing between Full Protection Areas, Sustainable Use Areas, and Indigenous Lands for group protection. The entire species modeling procedure was carried out using Species Distribution Models. Location records were obtained from platforms such as SpeciesLink, GBIF, the Hydroatlas database, and WorldClim for bioclimatic variables adjusted with algorithms like Maximum Entropy, Random Forest, Support Vector Machine, and Gaussian-Bayesian. Indigenous lands cover more than 50% of the distribution areas of chelonian species in the Brazilian Amazon. Protected areas with higher conservation importance (Full Protection Areas and Sustainable Use Areas) hold less than 15% of the combined species distribution. Researchers face significant challenges when making decisions with models, especially in conservation efforts involving diverse taxa that differ significantly from one another within a group of individuals.
Coinfection frequency in water flea populations is a mere reflection of parasite diversity
Authors: Halle Snir , Hirshberg Ofir , Manzi Florent , Wolinska Justyna , Ben-Ami Frida 
Published: May 2024

AbstractIn nature, parasite species often coinfect the same host. Yet, it is not clear what drives the natural dynamics of coinfection prevalence. The prevalence of coinfections might be affected by interactions among coinfecting species, or simply derive from parasite diversity. Identifying the relative impact of these parameters is crucial for understanding patterns of coinfections. We studied the occurrence and likelihood of coinfections in natural populations of water fleas (Daphnia magna). Coinfection prevalence was within the bounds expected by chance and parasite diversity had a strong positive effect on the likelihood of coinfections. Additionally, coinfection prevalence increased over the season and became as common as a single infection. Our results demonstrate how patterns of coinfection, and particularly their temporal variation, are affected by overlapping epidemics of different parasites. We suggest that monitoring parasite diversity can help predict where and when coinfection prevalence will be high, potentially leading to increased health risks to their hosts.
MSC-derived exosomal miR-140-3p improves cognitive dysfunction in sepsis-associated encephalopathy by HMGB1 and S-lactoylglutathione metabolism
Authors: Ma Ying , She Xingguo , Liu Yang , Qin Xian 
Published: May 2024

AbstractMiRNAs in mesenchymal stem cells (MSCs)-derived exosome (MSCs-exo) play an important role in the treatment of sepsis. We explored the mechanism through which MSCs-exo influences cognitive impairment in sepsis-associated encephalopathy (SAE). Here, we show that miR-140-3p targeted Hmgb1. MSCs-exo plus miR-140-3p mimic (Exo) and antibiotic imipenem/cilastatin (ABX) improve survival, weight, and cognitive impairment in cecal ligation and puncture (CLP) mice. Exo and ABX inhibit high mobility group box 1 (HMGB1), IBA-1, interleukin (IL)-1β, IL-6, iNOS, TNF-α, p65/p-p65, NLRP3, Caspase 1, and GSDMD-N levels. In addition, Exo upregulates S-lactoylglutathione levels in the hippocampus of CLP mice. Our data further demonstrates that Exo and S-lactoylglutathione increase GSH levels in LPS-induced HMC3 cells and decrease LD and GLO2 levels, inhibiting inflammatory responses and pyroptosis. These findings suggest that MSCs-exo-mediated delivery of miR-140-3p ameliorates cognitive impairment in mice with SAE by HMGB1 and S-lactoylglutathione metabolism, providing potential therapeutic targets for the clinical treatment of SAE.
Structural basis for the regulation of plant transcription factor WRKY33 by the VQ protein SIB1
Authors: Dong Xu , Yu Lulu , Zhang Qiang , Yang Ju , Gong Zhou , Niu Xiaogang , Li Hongwei , Zhang Xu , Liu Maili , Jin Changwen , Hu Yunfei 
Published: May 2024

AbstractThe WRKY transcription factors play essential roles in a variety of plant signaling pathways associated with biotic and abiotic stress response. The transcriptional activity of many WRKY members are regulated by a class of intrinsically disordered VQ proteins. While it is known that VQ proteins interact with the WRKY DNA-binding domains (DBDs), also termed as the WRKY domains, structural information regarding VQ-WRKY interaction is lacking and the regulation mechanism remains unknown. Herein we report a solution NMR study of the interaction between Arabidopsis WRKY33 and its regulatory VQ protein partner SIB1. We uncover a SIB1 minimal sequence neccessary for forming a stable complex with WRKY33 DBD, which comprises not only the consensus “FxxhVQxhTG” VQ motif but also its preceding region. We demonstrate that the βN-strand and the extended βN-β1 loop of WRKY33 DBD form the SIB1 docking site, and build a structural model of the complex based on the NMR paramagnetic relaxation enhancement and mutagenesis data. Based on this model, we further identify a cluster of positively-charged residues in the N-terminal region of SIB1 to be essential for the formation of a SIB1-WRKY33-DNA ternary complex. These results provide a framework for the mechanism of SIB1-enhanced WRKY33 transcriptional activity.
Growth phase-dependent reorganization of cryptophyte photosystem I antennae
Authors: Zhang Shumeng , Si Long , Su Xiaodong , Zhao Xuelin , An Xiaomin , Li Mei 
Published: May 2024

AbstractPhotosynthetic cryptophytes are eukaryotic algae that utilize membrane-embedded chlorophyll a/c binding proteins (CACs) and lumen-localized phycobiliproteins (PBPs) as their light-harvesting antennae. Cryptophytes go through logarithmic and stationary growth phases, and may adjust their light-harvesting capability according to their particular growth state. How cryptophytes change the type/arrangement of the photosynthetic antenna proteins to regulate their light-harvesting remains unknown. Here we solve four structures of cryptophyte photosystem I (PSI) bound with CACs that show the rearrangement of CACs at different growth phases. We identify a cryptophyte-unique protein, PsaQ, which harbors two chlorophyll molecules. PsaQ specifically binds to the lumenal region of PSI during logarithmic growth phase and may assist the association of PBPs with photosystems and energy transfer from PBPs to photosystems.
Self-reverting vortices in chiral active matter
Authors: Caprini L. , Liebchen B. , Löwen H. 
Published: May 2024

AbstractThere is currently a strong interest in the collective behavior of chiral active particles that can propel and rotate themselves. In the presence of alignment interactions for many chiral particles, chiral self-propulsion can induce vortex patterns in the velocity fields. However, these emerging patterns are non-permanent, and do not induce global vorticity. Here we combine theoretical arguments and computer simulations to predict a so-far unknown class of collective behavior. We show that, for chiral active particles, vortices with significant dynamical coherence emerge spontaneously. They originate from the interplay between attraction interactions and chirality in the absence of alignment interactions. Depending on parameters, the vortices can either feature a constant vorticity or a vorticity that oscillates periodically in time, resulting in self-reverting vortices. Our results may guide future experiments to realize customized collective phenomena such as spontaneously rotating gears and patterns with a self-reverting order.
Teleconnection of the Quasi-biennial oscillation with boreal winter surface climate in Eurasia and North America
Authors: Kumar Vinay , Hitchman Matthew H. , Du Wenyuan , Dhaka S. K. , Yoden Shigeo 
Published: May 2024

AbstractAn improved understanding of dynamical coupling from regional to global scales via tropospheric or stratospheric region can be helpful in improving seasonal forecasts for a given region of interest. Here we investigate dynamical coupling between the equatorial stratospheric Quasi-biennial oscillation and the boreal winter surface climate of the Northern Hemisphere mid and high latitudes using 42 years of data (1979–2020). For neutral El Niño Southern Oscillation periods, the Quasi-biennial oscillation westerly phase at 70 hPa favors high sea level pressure in the polar region, colder conditions and deeper snow over Eurasia and North America, and the opposite effects for the easterly phase. When Quasi-biennial oscillation anomalies arrive near the tropopause, it is observed that planetary wave activity is enhanced towards to extratropical region during westerly phase and reduced during easterly phase. This teleconnection pathway via the upper troposphere and lower stratosphere to the high latitude surface is independent of the “stratospheric pathway” (Holton-Tan mechanism). Diagnosis of this pathway can help to improve understanding of sub-seasonal to seasonal variations, and long-range forecasting over Eurasia and North America.
Interactive learning of natural sign language with radar
Authors: Kurtoğlu Emre , DeHaan Kenneth , Pezzarossi Caroline Kobek , Griffin Darrin J. , Crawford Chris , Gurbuz Sevgi Z. 
Published: May 2024

AbstractOver the past decade, there have been great advancements in radio frequency sensor technology for human–computer interaction applications, such as gesture recognition, and human activity recognition more broadly. While there is a significant amount of study on these topics, in most cases, experimental data are acquired in controlled settings by directing participants what motion to articulate. However, especially for communicative motions, such as sign language, such directed data sets do not accurately capture natural, in situ articulations. This results in a difference in the distribution of directed American Sign Language (ASL) versus natural ASL, which severely degrades natural sign language recognition in real‐world scenarios. To overcome these challenges and acquire more representative data for training deep models, the authors develop an interactive gaming environment, ChessSIGN, which records video and radar data of participants as they play the game without any external direction. The authors investigate various ways of generating synthetic samples from directed ASL data, but show that ultimately such data does not offer much improvement over just initialising using imagery from ImageNet. In contrast, an interactive learning paradigm is proposed by the authors in which model training is shown to improve as more and more natural ASL samples are acquired and augmented via synthetic samples generated from a physics‐aware generative adversarial network. The authors show that the proposed approach enables the recognition of natural ASL in a real‐world setting, achieving an accuracy of 69% for 29 ASL signs—a 60% improvement over conventional training with directed ASL data.
Exploration of morphological coherence in open clusters with a “core-shell” structure
Authors: Hu Qingshun , Zhang Yu , Qin Songmei , Zhong Jing , Chen Li , Luo Yangping 
Published: May 2024

Context. The morphology of open clusters plays a major role in the study of their dynamic evolution. The study of their morphological coherence, namely, the three-dimensional (3D) difference between the inner and outer morphologies of open clusters, allows us to obtain a better understanding of the morphological evolution of open clusters.
Aims. We aim to investigate the morphological coherence of 132 open clusters with up to 1 kpc from the Sun in the three-dimensional (3D) space within the heliocentric cartesian coordinate frame. The 132 open clusters have a 3D core-shell structure and conform to the ellipsoidal model, with all of them coming from a catalog of publicly available clusters in the literature.
Methods. We employed the ellipsoid fitting method to delineate the 3D spatial structure of the sample clusters, while using the morphological dislocation (MD) defined in our previous work and the ellipticity ratio (ER) of the clusters’ inner and outer structures to characterize the morphological coherence of the sample clusters.
Results. The results show an inverse correlation between the ER of the sample clusters and the number of their members, indicating that sample clusters with a much more elliptical external morphology than internal shape generally tend to host a large number of members. Meanwhile, a slight shrinking of the MD of the sample clusters with their members’ number may shed light on the significant role of the gravitational binding of the sample clusters in maintaining their morphological stability. Moreover, there are no correlations between the MD and ER of the sample clusters and their age. They are also not significantly correlated with the X-axis, the Y-axis, their orbital eccentricities, and the radial and vertical forces on them. However, the ER of the sample clusters displays some fluctuations in the distributions between it and the above covariates, implying that the morphologies of the sample clusters are sensitive to the external environment if sample effects are not taken into account. Finally, the analysis of the 3D spatial shapes of sample clusters with a small ER or a large ER demonstrates that the number of members lays an important foundation for forming a dense internal system for sample clusters. At the same time, the MD of the sample clusters can serve well as an indicator of their morphological stability, which is built upon a certain amount of member stars.
Conclusions. We present a new insight into the morphological coherence of open clusters, attributed to the combination of their gravitational binding capacity and external environmental perturbations.
Time-dependent, long-term hydrodynamic simulations of the inner protoplanetary disk
Authors: Cecil M. , Gehrig L. , Steiner D. 
Published: May 2024

Context. The final stages of a protoplanetary disk are essential for our understanding of the formation and evolution of planets. Photoevaporation is an important mechanism that contributes to the dispersal of an accretion disk and has significant consequences for the disk’s lifetime. However, the combined effects of photoevaporation and star-disk interaction have not been investigated in previous studies.
Aims. A photoevaporative disk evolution model including a detailed formulation of the inner star-disk interaction region will improve the understanding of the final stages of disk evolution.
Methods. We combined an implicit disk evolution model with a photoevaporative mass-loss profile. By including the innermost disk regions down to 0.01 AU, we could calculate the star-disk interaction, the stellar spin evolution, and the transition from an accreting disk to the propeller regime self-consistently. Starting from an early Class II star-disk system (with an age of 1 Myr), we calculated the long-term evolution of the system until the disk becomes almost completely dissolved.
Results. Photoevaporation has a significant effect on disk structure and evolution. The radial extent of the dead zone decreases, and the number of episodic accretion events (outbursts) is reduced by high stellar X-ray luminosities. Reasonable accretion rates (>10−8 M⊙yr) in combination with photoevaporative gaps are possible for a dead zone that is still massive enough to develop episodic accretion events. Furthermore, the stellar spin evolution during the Class II evolution is less affected by the star-disk interaction in the case of high X-ray luminosities.
Conclusions. Our results suggest that the formation of planets, especially habitable planets, in the dead zone is strongly impaired in the case of strong X-ray luminosities. Additionally, the importance of the star-disk interaction during the Class II phase with respect to the stellar spin evolution is reduced.
Synergistic anxiolytic efficacy exploring the combined effects of
diazepam and zinc chloride in wistar albino rats
Authors: Naik Vishwani V. , Desai Vedita Hegde , Noronha Sam 
Published: May 2024

AbstractCombinations of medications are frequently employed when their effects are
similar. Beyond aiding in the reduction of medication dosages, this approach may
yield additional positive outcomes. Studies have shown that zinc can mitigate
anxiety-related behavior in laboratory animals. This study aimed to investigate
the potential stabilizing effects of zinc chloride and diazepam in Wistar albino
rats.Five groups, each comprising six animals. Test groups included two combinations
of zinc chloride and diazepam, each with two different doses of diazepam (1 and
2 mg/kg) and 10 mg/kg of zinc chloride. Four established anxiety models—the
Elevated Plus Maze (EPM), the hole board, the light and dark box, and the mirror
chamber—were employed to assess the anxiolytic effects. The combination of zinc
chloride and diazepam proved to be more effective than the individual doses of
zinc chloride and diazepam, indicating enhanced anxiolytic effects.
Remote-Carbonyl-Directed Consecutive Arylation of Terminal Alkenes for the Synthesis of Tetrasubstituted Olefins
Authors: Du Yu , Su Weiping , Li Kun , Luan Runze 
Published: May 2024

AbstractThe highly efficient synthesis of all-carbon tetrasubstituted olefins has been a challenge for decades, especially of multi-aryl-substituted olefins which are widely used in functional organic materials and pharmaceuticals. This work presents a carbonyl-directed palladium-catalyzed consecutive arylation of terminal alkenes with aryl iodides under mild conditions, in which a series of triarylated tetrasubstituted olefins were obtained in moderate yields. Because a weak chelation effect is generally difficult to support such a thorough trifold Heck arylation, and β-trans-selective alkenyl C–H activation cannot be achieved via a twisted endo-metallocyclic intermediate, the key to success is the compatibility between several mechanisms, including Heck reaction, C–H activation and E/Z-isomerization. Here, the judicious selection of a flexible-alkyl-chain-tethered carbonyl group seems to be critical, as it provides a proper chelation effect that not only assists distal alkenyl functionalization or isomerization, but also avoids byproducts caused by other possible β-H elimination or migration. The strategy developed herein greatly streamlines the preparation of the target molecules, and the protocol covers a range of readily available terminal alkenes bearing a native directing group (i.e., aldehyde, ketone and ester) and aryl iodides.