bluuebunny/crossref_metadata_2025_split huggingface dataset:
Colorless Near‐Infrared Absorbing Dyes Based on B‐N Fused Donor‐Acceptor‐Donor π‐Conjugated Molecules for Organic Phototransistors
Authors: Yokoyama Soichi , Utsunomiya Sakura , Seo Takuji , Saeki Akinori , Ie Yutaka 
Published: June 2024

AbstractThe introduction of a colorless function to organic electronic devices allows responses to light in the near‐infrared (NIR) region and is expected to broaden the applications of these devices. However, the development of a colorless NIR dye remains a challenge due to the lack of a rational molecular design for controlling electronic transitions. In this study, to suppress the π‐π* transitions in the visible region, polycyclic donor‐acceptor‐donor π‐conjugated molecules with boron bridges (Py‐FNTz‐B and IP‐FNTz‐B) are designed and synthesized, which contain pyrrole or indenopyrrole as donor units with fluorinated naphthobisthiadiazole (FNTz) as an acceptor unit. The pyrrole end‐capped Py‐FNTz‐B shows an absorption band in the NIR region without distinct visible‐light absorption, which has led to the establishment of colorless characteristics. The indenopyrrole end‐capped IP‐FNTz‐B shows a narrow optical energy gap of 0.87 eV in films. Time‐resolved microwave conductance and field‐effect transistors demonstrate the semiconducting characteristics of these molecules, and Py‐FNTz‐B‐based devices function as NIR phototransistors. Theoretical analyses indicate that the combination of a polyene‐like electronic structure with orbital symmetry is important to obtain NIR wavelength‐selective absorption. This study suggests that a molecular design based on electronic structures can be effective in the development of colorless NIR‐absorbing dyes for organic electronics.
Body composition characteristics and influencing factors of different parts of sarcopenia in elderly people: A community‐based cross‐sectional survey
Authors: Dong Xinying , Bi Bingqing , Hu Yifei , Wang Li , Liu Xinying , Li Wentao , Li Mingyue , Xiang Tong , Li Shugang , Wu Hao 
Published: June 2024

AbstractObjectivesThis study aims to describe the differences in body composition among different body parts of the elderly in the community and its relationship with sarcopenia.MethodsElderly people aged ≥65 underwent bioelectric impedance analysis testing and were categorized into a sarcopenia group, possible sarcopenia group, and control group. The characteristics of body composition indicators in different parts and their relationship with different stages of sarcopenia were analyzed.ResultsThe sarcopenia group illustrated the lowest values of FFM, FFM%, BFM, BFM%, ICW, and limb PhA, along with higher ECW/TBW in the trunk and left leg compared to the control group. The possible sarcopenia group showed lower FFM% in limbs and trunk, and higher BFM% compared to the control group. Gender differences in elderly body composition were observed, with an increase in BFM% in various body parts posing a risk factor for possible sarcopenia in elderly males, whereas an increase in BFM% except in the left arm was a protective factor for sarcopenia in elderly females.ConclusionThe body composition of the elderly in the community varied significantly in different stages of sarcopenia and genders, which correlated with sarcopenia.
Clinical biomarker‐based biological aging and risk of benign prostatic hyperplasia: A large prospective cohort study
Authors: Huang Qiao , Li Bing‐Hui , Wang Yong‐Bo , Zi Hao , Zhang Yuan‐Yuan , Li Fei , Fang Cheng , Tang Shi‐Di , Jin Ying‐Hui , Huang Jiao , Zeng Xian‐Tao 
Published: June 2024

AbstractObjectiveChronological age (CAge), biological age (BAge), and accelerated age (AAge) are all important for aging‐related diseases. CAge is a known risk factor for benign prostatic hyperplasia (BPH); However, the evidence of association of BAge and AAge with BPH is limited. This study aimed to evaluate the association of CAge, Bage, and AAge with BPH in a large prospective cohort.MethodA total of 135,933 males without BPH at enrolment were extracted from the UK biobank. We calculated three BAge measures (Klemera–Doubal method, KDM; PhenoAge; homeostatic dysregulation, HD) based on 16 biomarkers. Additionally, we calculated KDM‐BAge and PhenoAge‐BAge measures based on the Levine method. The KDM‐AAge and PhenoAge‐AAge were assessed by the difference between CAge and BAge and were standardized (mean = 0 and standard deviation [SD] = 1). Cox proportional hazard models were applied to assess the associations of CAge, Bage, and AAge with incident BPH risk.ResultsDuring a median follow‐up of 13.150 years, 11,811 (8.690%) incident BPH were identified. Advanced CAge and BAge measures were associated with an increased risk of BPH, showing threshold effects at a later age (all P for nonlinearity <0.001). Nonlinear relationships between AAge measures and risk of BPH were also found for KDM‐AAge (P = 0.041) and PhenoAge‐AAge (P = 0.020). Compared to the balance comparison group (−1 SD < AAge < 1 SD), the accelerated aging group (AAge > 2 SD) had a significantly elevated BPH risk with hazard ratio (HR) of 1.115 (95% CI, 1.000–1.223) for KDM‐AAge and 1.180 (95% CI, 1.068–1.303) for PhenoAge‐AAge, respectively. For PhenoAge‐AAge, subgroup analysis of the accelerated aging group showed an increased HR of 1.904 (95% CI, 1.374–2.639) in males with CAge <50 years and 1.233 (95% CI, 1.088–1.397) in those having testosterone levels <12 nmol/L. Moreover, AAge‐associated risk of BPH was independent of and additive to genetic risk.ConclusionsBiological aging is an independent and modifiable risk factor for BPH. We suggest performing active health interventions to slow biological aging, which will help mitigate the progression of prostate aging and further reduce the burden of BPH.
Effect of L‐oxiracetam and oxiracetam on memory and cognitive impairment in mild‐to‐moderate traumatic brain injury patients: Study protocol for a randomized controlled trial
Authors: Liu Tao , Liu Mingqi , Nie Meng , Zhao Zhihao , Liu Xuanhui , Qian Yu , Yu Yunhu , Sha Zhuang , Wu Chenrui , Yuan Jiangyuan , Jiang Weiwei , Lv Chuanxiang , Mi Liang , Tian Yu , Zhang Jianning , Jiang Rongcai 
Published: June 2024

AbstractObjectivesPatients with traumatic brain injury (TBI) often suffer memory and cognitive impairments, and oxiracetam‐like drugs are considered to have a positive impact on these symptoms potentially. However, the efficacy and safety of L‐oxiracetam and oxiracetam in TBI patients have not been sufficiently investigated.MethodsThe study adopts a multicenter, randomized, double‐blind, parallel‐group, phase 3 clinical trial design in 74 centers across 51 hospitals in China. A total of 590 TBI patients meeting criteria will be randomly allocated into three groups in a 2:2:1 ratio: L‐oxiracetam group, oxiracetam group, and placebo group. The treatment period is 14 days, with a follow‐up period of 90 days. The primary outcome measure is the change in the Loewenstein Occupational Therapy Cognitive Assessment score at 90 days after treatment. Secondary outcomes include changes in other cognitive assessments, neurological function, activities of daily living, and safety assessments.DiscussionThere is no robust evidence to suggest that L‐oxiracetam and oxiracetam can enhance memory and cognitive function in patients with mild to moderate TBI. This study has the potential to answer this crucial clinical question.Trial registrationchinadrugtrials.org.cn, identifier CTR20192539; ClinicalTrials.gov, identifier NCT04205565.
Dynamic interdependence between ethanol and biofuel‐related agricultural commodities—cDCC‐FIAPARCH approach
Authors: Živkov Dejan , Kuzman Boris , Nataša Papić‐Blagojević 
Published: June 2024

AbstractBiofuel production is one of the key topics in today's world, which inevitably raises the question of the relationship between ethanol and agricultural commodities. The nexus between corn and ethanol is well known in the literature, but the link involving other biofuel feedstocks is relatively poorly explored. Therefore, this paper research the dynamic nexus between ethanol and five agricultural commodities using the cDCC‐FIAPARCH model, while two additional analyses complement the main results. Dynamic conditional correlation between ethanol and corn is the highest and reaches an average of 50%, while wheat and soybean follow with 31%. A rolling regression analysis reveals the relationship between conditional volatilities and conditional correlations, where the assets with lower conditional volatility have a more significant impact on conditional correlation. The findings may have several practical implications for agents working with ethanol and agricultural commodities, such as food security assessment, efficiency of supply chains and portfolio construction. [EconLit Citations: C61, O13, Q16].
Droplet 3D cryobioprinting for fabrication of free‐standing and volumetric structures
Authors: Weygant Joshua , Entezari Ali , Koch Fritz , Galaviz Ricardo André , Garciamendez Carlos Ezio , Hernández Pável , Ortiz Vanessa , Ruiz David Sebastián Rendon , Aguilar Francisco , Andolfi Andrea , Cai Ling , Maharjan Sushila , Osorio Anayancy , Zhang Yu Shrike 
Published: June 2024

AbstractDroplet‐based bioprinting has shown remarkable potential in tissue engineering and regenerative medicine. However, it requires bioinks with low viscosities, which makes it challenging to create complex 3D structures and spatially pattern them with different materials. This study introduces a novel approach to bioprinting sophisticated volumetric objects by merging droplet‐based bioprinting and cryobioprinting techniques. By leveraging the benefits of cryopreservation, we fabricated, for the first time, intricate, self‐supporting cell‐free or cell‐laden structures with single or multiple materials in a simple droplet‐based bioprinting process that is facilitated by depositing the droplets onto a cryoplate followed by crosslinking during revival. The feasibility of this approach is demonstrated by bioprinting several cell types, with cell viability increasing to 80%–90% after up to 2 or 3 weeks of culture. Furthermore, the applicational capabilities of this approach are showcased by bioprinting an endothelialized breast cancer model. The results indicate that merging droplet and cryogenic bioprinting complements current droplet‐based bioprinting techniques and opens new avenues for the fabrication of volumetric objects with enhanced complexity and functionality, presenting exciting potential for biomedical applications.
Einblicke in die Mechanochemische Glasbildung von Zeolithischen Imidazolat‐Gerüstverbindungen
Authors: Xue Wen‐Long , Das Chinmoy , Weiß Jan‐Benedikt , Henke Sebastian 
Published: June 2024

AbstractGläser von metallorganischen Gerüstverbindungen (MOF‐Gläser), die für ihr Potenzial bei der Gastrennung, in der Optik und als Festkörperelektrolyte bekannt sind, profitieren von der Verarbeitbarkeit ihres (unterkühlten) flüssigen Zustands. Traditionell werden MOF‐Gläser durch Erhitzen von MOF‐Kristallen über ihren Schmelzpunkt und anschließendes Abkühlen des flüssigen MOF auf Raumtemperatur unter einer inerten Atmosphäre hergestellt. Diese Technik des Schmelzquenchens ist zwar effektiv, erfordert aber aufgrund der hohen Temperaturen einen hohen Energieaufwand. Außerdem schränkt es den Spielraum für die Entwicklung neuer Materialien ein, da nur die thermisch hochstabilen Kombinationen von Metallionen und Linkern in Frage kommen. Eine Alternative, das mechanische Mahlen bei Raumtemperatur, hat sich als geeignet erwiesen, MOF‐Kristalle in amorphe Phasen umzuwandeln. Die spezifischen Bedingungen, unter denen diese amorphen Phasen ein glasähnliches Verhalten zeigen, sind jedoch noch nicht bekannt. In dieser Studie untersuchen wir die mechanochemische Amorphisierung und Verglasung einer Vielzahl von zeolithischen Imidazolat‐Gerüstverbindungen (ZIFs) mit verschiedenen Linkern und unterschiedlichen Metallionen (Zn2+, Co2+ und Cu2+) bei Raumtemperatur. Unsere Ergebnisse zeigen, dass ZIFs, die schmelzbar sind, durch Kugelmahlen erfolgreich in Gläser umgewandelt werden können. Bemerkenswerterweise können auch einige nicht schmelzbare ZIFs mit Hilfe der Kugelmahltechnik verglast werden, wie die Herstellung des ersten ZIF‐Glases mit Cu2+‐Ionen zeigt.
A Redox‐Active Phenothiazine‐based Pd2L4‐Type Coordination Cage and Its Isolable Crystalline Polyradical Cations
Authors: Huang Bin , Zhou Manfei , Hong Qiong‐Yan , Wu Meng‐Xiang , Zhao Xiao‐Li , Xu Lin , Gao En‐Qing , Yang Hai‐Bo , Shi Xueliang 
Published: June 2024

AbstractPolyradical cages are of great interest because they show very fascinating physical and chemical properties, but many challenges remain, especially for their synthesis and characterization. Herein, we present the synthesis of a polyradical cation cage 14.+ through post‐synthetic oxidation of a redox‐active phenothiazine‐based Pd2L4‐type coordination cage 1. It′s worth noting that 1 exhibits excellent reversible electrochemical and chemical redox activity due to the introduction of a bulky 3,5‐di‐tert‐butyl‐4‐methoxyphenyl substituent. The generation of 14.+ through reversible electrochemical oxidation is investigated by in situ UV/Vis‐NIR and EPR spectroelectrochemistry. Meanwhile, chemical oxidation of 1 can also produce 14.+ which can be reversibly reduced back to the original cage 1, and the process is monitored by EPR and NMR spectroscopies. Eventually, we succeed in the isolation and single crystal X‐ray diffraction analysis of 14.+, whose electronic structure and conformation are distinct to original 1. The magnetic susceptibility measurements indicate the predominantly antiferromagnetic interactions between the four phenothiazine radical cations in 14.+. We believe that our study including the facile synthesis methodology and in situ spectroelectrochemistry will shed some light on the synthesis and characterization of novel polyradical systems, opening more perspectives for developing functional supramolecular cages.
Structural Optimization of Azacryptands for Targeting Three‐Way DNA Junctions
Authors: Pipier Angélique , Chetot Titouan , Kalamatianou Apollonia , Martin Nicolas , Caroff Maëlle , Britton Sébastien , Chéron Nicolas , Trantírek Lukáš , Granzhan Anton , Monchaud David 
Published: June 2024

AbstractTransient melting of the duplex‐DNA (B‐DNA) during DNA transactions allows repeated sequences to fold into non‐B‐DNA structures, including DNA junctions and G‐quadruplexes. These noncanonical structures can act as impediments to DNA polymerase progression along the duplex, thereby triggering DNA damage and ultimately jeopardizing genomic stability. Their stabilization by ad hoc ligands is currently being explored as a putative anticancer strategy since it might represent an efficient way to inflict toxic DNA damage specifically to rapidly dividing cancer cells. The relevance of this strategy is only emerging for three‐way DNA junctions (TWJs) and, to date, no molecule has been recognized as a reference TWJ ligand, featuring both high affinity and selectivity. Herein, we characterize such reference ligands through a combination of in vitro techniques comprising affinity and selectivity assays (competitive FRET‐melting and TWJ Screen assays), functional tests (qPCR and Taq stop assays) and structural analyses (molecular dynamics and NMR investigations). We identify novel azacryptands TrisNP‐amphi and TrisNP‐ana as the most promising ligands, interacting with TWJs with high affinity and selectivity. These ligands represent new molecular tools to investigate the cellular roles of TWJs and explore how they can be exploited in innovative anticancer therapies.
Insights Into the Mechanochemical Glass Formation of Zeolitic Imidazolate Frameworks
Authors: Xue Wen‐Long , Das Chinmoy , Weiß Jan‐Benedikt , Henke Sebastian 
Published: June 2024

AbstractMetal–organic framework (MOF) glasses, known for their potential in gas separation, optics, and solid‐state electrolytes, benefit from the processability of their (supercooled) liquid state. Traditionally, MOF glasses are produced by heating MOF crystals to their melting point and then cooling the liquid MOF to room temperature under an inert atmosphere. While effective, this melt‐quenching technique requires high energy due to the high temperatures involved. It also limits the scope of new material development by restricting the compositional range to only those combinations of metal ions and linkers that are highly thermally stable. An alternative, mechanical milling at room temperature, has demonstrated its capability to transform MOF crystals into amorphous phases. However, the specific conditions under which these amorphous phases exhibit glass‐like behavior remain uncharted. In this study, we explore the mechanochemical amorphization and vitrification of a variety of zeolitic imidazolate frameworks (ZIFs) with diverse linkers and different metal ions (Zn2+, Co2+ and Cu2+) at room temperature. Our findings demonstrate that ZIFs capable of melting can be successfully converted into glasses through ball‐milling. Remarkably, some non‐meltable ZIFs can also be vitrified using the ball‐milling technique, as highlighted by the preparation of the first Cu2+‐based ZIF glass.
Targeted and untargeted metabolomics and lipidomics in dried blood microsampling: Recent applications and perspectives
Authors: Couacault Pauline , Avella Dennisse , Londoño‐Osorio Sara , Lorenzo Ana S. , Gradillas Ana , Kärkkäinen Olli , Want Elizabeth , Witting Michael 
Published: June 2024

AbstractBlood microsampling (BµS) offers an alternative to conventional methods that use plasma or serum for profiling human health, being minimally invasive and cost effective, especially beneficial for vulnerable populations. We present a non‐systematic review that offers a synopsis of the analytical methods, applications and perspectives related to dry blood microsampling in targeted and untargeted metabolomics and lipidomics research in the years 2022 and 2023. BµS shows potential in neonatal and paediatric studies, therapeutic drug monitoring, metabolite screening, biomarker research, sports supervision, clinical disorders studies and forensic toxicology. Notably, dried blood spots and volumetric absorptive microsampling options have been more extensively studied than other volumetric technologies. Therefore, we suggest that a further investigation and application of the volumetric technologies will contribute to the use of BµS as an alternative to conventional methods. Conversely, we support the idea that harmonisation of the analytical methods when using BµS would have a positive impact on its implementation.
Developing Supramolecular Metallogel Derived from Pd2L4 Cage Molecule for Delivering an Anti‐Cancer Drug to Melanoma Cell B16−F10
Authors: Bera Sourabh , Dutta Abhishek , Dastidar Parthasarathi 
Published: June 2024

AbstractSupramolecular gels are an important class of materials that are promising for its wide range of applications including drug delivery. While supramolecular gels are intrinsically porous because of the 3D nano‐matrix (gel matrix) that is being formed due to supramolecular self‐assembly process involving the gelator molecules during gelation, additional nanopores can be introduced to the overall gel if the gelator molecule itself holds molecular cavity such as metal‐organic‐cage (MOC) molecules. A MOC having the molecular formula [(Pd2L24).4NO3].3H2O.2DMF.MeOH (Pd‐cage) (L2=5‐Azido‐N,N′‐di‐pyridin‐3‐yl‐isophthalamide) was successfully synthesized and characterized by FT‐IR, 1H NMR, ESI‐MS and single crystal X‐ray diffraction. Stimuli‐reversible supramolecular metallogel PdG could easily be formed from Pd‐cage in DMSO/water mixture. The molecular cage of Pd‐cage was demonstrated to be available for loading an anti‐cancer drug namely doxorubicin (DOX). Subsequently, DOX was also loaded within PdG and delivered to melanoma cell line B16−F10 displaying significant anti‐cancer activity as revealed by both MTT and scratch assay. Rheoreversibility of PdG and its ability to load and deliver DOX to cancer cells clearly raised hope for developing this metallogel further as topical anticancer gel.
Synthesis of Chlorophylls‐Doped Guanine Crystals with High Reflection and Depolarization for Green Camouflage Coating
Authors: Zhang Ying , Ren Yujing , Hao Jingyan , Gao Juan , Ma Yurong 
Published: June 2024

AbstractHyperspectral imaging technology can record the spatial and spectral information of the targets and significantly enhance the levels of military reconnaissance and target detection. It has scientific importance to mimic “homochromatic and homospectral” camouflage materials that have hyperspectral similarity with the green vegetation, one of the most common natural backgrounds. It is a big challenge to exquisitely simulate the spectral of green vegetation in visible and near‐infrared windows because of the slight differences between the artificial green dyes and vegetation, the instability of chlorophylls, and the easy loss of hydroxide bands due to the loss of water from the camouflage materials. Herein, a novel kind of biomimetic material of green vegetation was designed through the incorporation of chlorophylls into the crystal lattices of single‐crystalline anhydrous guanine microplates for the first time. The synthesized chlorophylls‐doped anhydrous guanine crystals exhibit high reflectance intensity and depolarization effect, thus can be applied as biomimetic camouflage materials that mimic green vegetation with high reflectivity and low polarization in the visible and near‐infrared regions. The factors influencing the formation of dye‐doped organic crystals under mild conditions were thoroughly investigated and the characterizations using electron microscopies and fluorescence confocal laser scanning microscopy clearly confirm the occlusion of chlorophylls into the crystal lattices of guanine crystals. The thermal stability experiments clearly indicate that the chlorophylls‐doped guanine crystals possess long‐term stability at high temperature. This study provides a new strategy for the synthesis of multifunctional materials comprised of organic crystals.
Defining Regional Water Distribution System Models
Authors: Tomić Saša , Najafi Nima , Ripley Heather , Huang Matthew , Skeens Brian 
Published: June 2024

Key TakeawaysWhat defines a regional water distribution system? An AWWA committee sorted through the characteristics of systems and their respective models to come up with a clear classification.Regional water distribution models are broken into two categories: regional transmission and regional emergency supply, with many models landing somewhere along the spectrum.A close examination of four regional water systems revealed the unique attributes and numerous considerations that make developing and maintaining hydraulic models complex.
Evaluating the Smart Technology Level of Water Purification Plants
Authors: Shin Dong Gi , Lee Jong Yun 
Published: June 2024

Key TakeawaysThe features of a smart water purification plant (SWPP) can include autonomous operation of treatment processes, energy management optimization, and facility preservation, using approaches that include artificial intelligence technology.Evaluation indicators were developed to measure the level of technology in K‐water's SWPPs.Practical demonstration at three K‐water SWPPs was used to validate the effectiveness of these indicators.