bluuebunny/crossref_metadata_2025_split huggingface dataset:
UJI EFEKTIVITAS EKSTRAK BUNGA TELANG (CLITORIA TERNATEA L.) SEBAGAI ANALGESIK PADA MENCIT (MUS MUSCULUS)
Authors: Mundriyastutik Yayuk , Lestari Diana Tri , Setyowati Endang , Nugraheni Diah Putri , Rusidah Yunita 
Published: May 2024

Nyeri adalah kondisi tidak nyaman, karena terdapat kerusakan jaringan. Pengobatan nyeri diberikan golongan analgesik. Ekstrak etanol (Clitoria ternatea L.) memiliki senyawa flavonoid, saponin, terpenoid, yang berpotensi sebagai analgesik, pada mencit yang diinduksi asam asetat. Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak etanol dari tanaman clitoria ternatea L. terhadap penurunan geliat mencit, yang diinduksi asam asetat 1%, dengan metode pengamatan writing test setelah diberikan dosis ekstrak 200;300; dan 400 mg, dan induksi asam asetat secara intraperitoneal dengan menghitung rata-rata geliat mencit, selanjutnya analisis data menggunakan SPSS versi 26. Perbandingan dosis I (200 mg/KgBB) mendapatkan rata-rata geliat 2,5; dosis II (300 mg/KgBB) mendapatkan rata-rata geliat 3,02; dosis III (400 mg/KgBB mendapatkan rata-rata geliat 2,30; dan uji kontrol positif ibuprofen (26 mg/KgBB) mendapatkan rata-rata geliat 3,22. Penelitian ini dapat disimpulkan bahwa masing-masing dosis tanaman (Clitoria ternatea L.) memiliki daya analgesik, akan tetapi dosis yang memiliki efektivitas signifikan adalah dosis II (300 mg/KgBB).
PENGALAMAN PASIEN HEMODIALISA YANG TERPASANG ARTERIOVENOUS FISTULA (AVF) BERDASARKAN PERSPEKTIF KUBLER ROSS DI RS ‘AISYIYAH KUDUS
Authors: Yulisetyaningrum Yulisetyaningrum , Dedi Blacius , Yunani Yunani 
Published: May 2024

Gagal ginjal kronis telah diakui sebagai salah satu masalah kesehatan dengan prevalensi terbanyak di seluruh dunia dengan 13,4% dari total populasi. Kondisi medis saat ini penatalaksanaan masih dengan hemodiafiltrasi jangka Panjang. Pasien dengan pengalaman pertama kali hemodialisa muncul rasa cemas karena ketakutan terhadap managemen terapi bahkan sampai adanya penolakan. Pemasangan dan pemeliharaan arteriovenus fistula merupakan salah satu masalah yang sering pada pasien. Pasien mengalami berbagai tahap kesedihan yang berbeda selama proses berduka, dan tidak semua orang dapat mencapai keadaan pikiran yang positif. Saat ini belum ada penelitian yang mengeksplorasi pengalaman pasien hemodialisa yang terpasang arteriovenous fistula (AVF). Tujuan penelitian untuk menggali pengalaman pasien hemodialisa yang terpasang arteriovenus fistula berdasarkan perspektif Kubler Ross di RS ‘Aisyiyah Kudus. Penelitian ini adalah penelitian kualitatif dengan pendekatan studi fenomenologi. Pengambilan data menggunakan in-depth interview, partisipan 11 orang yang terdiri partisipan pasien dan keluarga. Partisipan pasien merupakan pasien hemodialisa yang terpasang AVF satu tahun terakhir. Dari hasil penelitian didapatkan 4 tema yaitu (1) partisipan berespon menyangkal dan menerima sebagai pasien hemodialisa yang terpasang Avf Shunt, (2) Membatasi makan, minum dan perawatan Avf shunt di rumah, (3) Membutuhkan dukungan keluarga dan (4) Hambatan yang dialami keluarga pasien dalam psikologis, sosial dan ekonomi kemudian ditindaklanjuti dengan pembuatan buku panduan perawatan arteriovenus fistula dalam tahap penolakan.Kata Kunci : Arteriovenous fistula, hemodialisa, Kubler Ross, Pengalaman
Standard setting OSCE: A comparison of arbitrary and Hofstee methods in a low stake OSCE
Authors: Khan Uzma 
Published: May 2024

Objectives: To compare the cut scores and pass/fail rates achieved by arbitrary 60% method and Hofstee method in an undergraduate year 4 end semester objective structured clinical examination (OSCE) and check the possibility of using Hofstee method of standard setting in future exams.
Method: 102 medical students of year 4 underwent a 10 station OSCE exam conducted in a state of art simulation lab in 3 cycles. The cut scores were calculated using arbitrary method aiming at 60% of task achievement and by Hofstee method. The student’s obtained scores were compared for cut scores and pass rates for individual stations and the entire exam.
Results: The arbitrary and Hofstee methods of standard setting leads to different cut scores. For the individual stations it was 60% vs 65-70% and for the overall score it was 60% vs 70%. The percentage of students failing the exam is 13.7% based on arbitrary scores and is 29.4% when Hofstee cut score is applied.
Conclusions: The two methods lead to different cut scores and students’ failure rates. Overall, Hofstee method is more appropriate for assessing competencies in an OSCE exam in medical schools as it leads to calculation of cut scores based on the difficulty level of the station/exam and the examiners expected level of performance by the students.

Keywords:	Objective Structured Clinical Examination, Standard Setting, Hofstee Method, Arbitrary Method
Pengembangan Model Pembelajaran Berbasis Proyek Berbantu Game Edukasi di Taman Kanak-kanak
Authors: Sari Ayu Mustika , Rakimahwati Rakimahwati , Suryana Dadan , Jamna Jamaris , Jasrial Jasrial 
Published: May 2024

Pentingnya pengembangan model Project Based Lerning (PjBL) berbasis game edukasi, yang sangat diajurkan pada Pendidikan saat ini terutama pada penerapan kurikulum merdeka. Model PjBL memungkinkan anak terlibat aktif, meningkatkan konsep bermain bekerja sama, anak akan mengexplorasi, kolaborasi dan menerapkan konsep nyata yang sederhana di TK. Agar lebih mudah melakasanakan PjBL maka dibutuhkan game edukasi yang dapat memberikan gambaran tentang project apa yang akan dikerjakan. Penelitian ini menggunakan penelitian pengembangan (R&D) dengan desain pengembangan Plomp yang terdiri dari tahapan. Tahapan preliminary resaech dengan analisis model pembelajaran di TK yang menekankan pada keterlibatan anak dalam melakukan kegiatan secaranya. Analisis kebutuhan kurikulum merdeka lebih menekankan pembalajaran berbasis project based lerning. Analisis anak di TK usia 5-6 tahun, Analisis materi yaitu aku sayang bumi. Uji validitas menyatakan bahwa model project based lening berbasis game edukasi valid digunakan dengan persentase sangat valid yaitu 90,3%. Uji praktikalitas model project based lerning berbasis game edukasi sangat praktis dengan kriteria sangat praktis yaitu 87%.
«We Are Selfish; We Will Fight Only for Ourselves...» V.P. Potemkin’s Mission to Ankara (04.29–05.06.1939) and Turkish Policy of Forming a Security Belt Near National Borders in the Mid-1930s
Authors: Vasilyev Alexander D. 
Published: May 2024

In the context of growing military tension in Europe in the second half of the 1930s and the eventual Italian threat, the Turkish leadership was looking for ways to ensure national interests and push the threat of war away from Turkish borders. The system of international military-political alliances and bilateral pacts was considered by Turkish diplomats as a sufficient guarantee of sovereignty and preventing the advance of war to Turkish territory. One of the trends was a change in Turkey’s foreign policy orientation from relying only on the Soviet Union to connections with England. The fact that Germany remained the main trade and economic partner of the Turkish Republic also had a significant impact. In the context of growing political tension in Europe and the division of Czechoslovakia, the Soviet government proposed holding mutual consultations on security issues and possible opposition to the aggressor. On April 29, 1939, Deputy People’s Commissar for Foreign Affairs V.P. Potemkin was sent to Ankara. The main topic of discussion in Ankara was the conclusion of a multilateral pact of mutual assistance and security against the backdrop of growing German-Italian expansion. Despite the assistance provided by V.P. Potemkin, the negotiations in Ankara left the Soviet leadership with a taste of understatement and a feeling of veiled bargaining, giving a clear understanding that in the coming world war, Turkey, despite the system of international defensive pacts built by its leadership along the perimeter of the country, would be guided by the principles of national selfishness.
Babylonian Scholars Working for Ashurbanipal’s Library? Some Colophons with Cryptography and Learned Writings
Authors: May Natalie Naomi 
Published: May 2024

The article explores evidence for Babylonian scholars working for Ashurbanipal’s library. The colophons of Ashurbanipal’s library tablets are usually highly standardized and, as opposed to the colophons of private or temple libraries, do not contain any information about copyists. The colophons on Babylonian tablets found at Nineveh normally are very short and provide only theinformation about the original tablet. The colophons of the two scions of the prominent family of lamentation priests, descendants of Šumu-libši, the lamentation priest of Mardukat Esagil, contain their names written cryptographically. The article suggests the decipherment of this cryptography. Analysing this cryptography and juxtaposing it with the other Šumu-libši-related colophons on the tablets found in Assyria sheds light on the input of Babylonian scholars in creating the library of Ashurbanipal.
Consideraciones sostenibles para el diseño de urbanizaciones cerradas en la ciudad de Cuenca
Authors: Cajamarca Dacto Karina Elizabeth , Briones Rodríguez Jonnathan Javier , Morales González Janeth Alexandra , Nieto Páez Erick Fabricio 
Published: May 2024

Introducción: El estudio se enfoca en las urbanizaciones cerradas en Cuenca, Ecuador, que surgen como respuesta al crecimiento de las ciudades latinoamericanas y la búsqueda de seguridad y exclusividad. Se exploran las implicaciones de este modelo, como la fragmentación urbana y la segregación social. Objetivo: Evaluar las urbanizaciones cerradas en Cuenca para proponer estrategias de diseño urbano-arquitectónicas que contribuyan a un desarrollo más sostenible y equitativo, sustituyendo el modelo tradicional. Metodología: El estudio utiliza un enfoque cualitativo e interdisciplinario, basado en una revisión bibliográfica exhaustiva y análisis descriptivo y correlacional. Se emplea una matriz sintético-deductiva que integra lineamientos urbanísticos de la ONU para evaluar la habitabilidad y sostenibilidad de estas urbanizaciones. Resultados: Se identificaron diferencias marcadas en la percepción social entre los residentes dentro de la urbanización ("Los de adentro") y aquellos fuera de ella ("Los de afuera"). Los residentes internos valoran la seguridad y exclusividad, mientras que los externos sienten una desconexión y aumento de la delincuencia debido a la segregación espacial Conclusión: Las urbanizaciones cerradas en Cuenca reflejan desafíos similares observados en otras regiones, como la segregación social y espacial. Se necesitan políticas sostenibles que integren mejor estas comunidades con el tejido urbano de la ciudad, garantizando una calidad de vida más alta y un desarrollo urbano cohesivo y sostenible. Área de estudio general: Arquitectura Área de estudio específica: Urbanismo.
Bimbingan Teknis Inventaris Arsip Dokumen dan Bantuan Pengadaan Ruang Penyimpanan di Masjid Darul Mujahidin
Authors: Diana Irmawati Pradani  , Jayaputra Harsalim A. , Pratama Gindang Rain , Novianto Dandung 
Published: May 2024

Abstrak
Kegiatan pengabdian kepada masyarakat kali ini berlokasi di Takmir Masjid Darul Mujahidin yang merupakan salah satu organisasi masyarakat yang bergerak dalam bidang agama yang berada di Kecamatan Kedungkandang yang berlokasi di Jl. Rawa Pening No. 12 Kelurahan Madyopuro Kota Malang. Saat ini banyak sarana dan prasarana penunjang yang dimiliki oleh kepengurusan Takmir Masjid Darul Mujahidin. Salah satu yang menjadi permasalahan ialah mengenai inventarisir barang yang menjadi tanggung jawab pengurus organisasi belum dilakukan dengan baik. Selain itu penyimpanan dokumen penting juga belum tertata rapi. Demi menyempurnakan pengurusan dan pengawasan yang efektif terhadap sarana dan prasaran yang dimiliki organisasi terpilihlah pengadaan almari sebagai prioritas dalam pelaksanaan inventarisir pada Takmir Masjid Darul Mujahidin pada kegiatan pengabdian masyarakat ini. Setelah dilakukan penyerahan almari pada pihak Takmir Masjid Darul Mujahidin, selanjutnya dilakukan penyampian informasi terkait inventarisir dokumen / barang berupa Focus Group Discussion (FGD) kepada para pengurus mengenai langkah-langkah yang perlu dilakukan dalam inventarisir. Diharapkan dengan adanya bimbingan teknis tersebut, organisasi pada Takmir Masjid Darul Mujahidin dapat berjalan lebih optimal terkait tentang pentingnya inventarisir dokumen / barang, sehingga nantinya akan menimbulkan rasa memiliki menjaga keberadaan barang invetarisir tersebut.
Inflammation and endothelial function relevant genetic polymorphisms, carotid atherosclerosis, and vascular events in high-risk stroke population
Authors: Chen Hong , Qing Ting , Luo Hua , Yu Ming , Wang Yanfen , Wei Wei , Xie Yong , Yi Xingyang 
Published: May 2024

AimTo identify the associations of 19 single nucleotide polymorphisms (SNPs) in genes involved in inflammation and endothelial function and carotid atherosclerosis with subsequent ischemic stroke and other vascular events in the high-risk stroke population.MethodsThis was a multicenter community-based sectional survey and prospective cohort study in Sichuan, southwestern China. Eight communities were randomly selected, and the residents in each community were surveyed using a structured face-to-face questionnaire. Carotid ultrasonography and DNA information were obtained from 2,377 out of 2,893 individuals belonging to a high-risk stroke population. Genotypes of the 19 SNPs in genes involved in inflammation and endothelial function were measured. All the 2,377 subjects were followed up for 4.7 years after the face-to-face survey. The primary outcome was ischemic stroke, and the secondary outcome was a composite of vascular events.ResultsAmong the 2,377 subjects, 2,205 (92.8%) completed a 4.7-year follow-up, 947 (42.9%) had carotid atherosclerosis [372 (16.9%) carotid vulnerable plaque, 405 (18.4%) mean IMT &gt; 0.9 mm, 285 (12.0%) carotid stenosis ≥15%]. Outcomes occurred in 158 (7.2%) subjects [92 (4.2%) ischemic stroke, 17 (0.8%) hemorrhagic stroke, 48 (2.2%) myocardial infarction, and 26 (1.2%) death] during follow-up. There was a significant gene–gene interaction among ITGA2 rs1991013, IL1A rs1609682, and HABP2 rs7923349 in the 19 SNPs. The multivariate logistic regression model revealed that carotid atherosclerosis and the high-risk interactive genotypes among the three SNPs were independent with a higher risk for ischemic stroke (OR = 2.67, 95% CI: 1.52–6.78, p = 0.004; and OR = 3.11, 95% CI: 2.12–9.27, p &lt; 0.001, respectively) and composite vascular events (OR = 3.04, 95% CI: 1.46–6.35, p &lt; 0.001; and OR = 3.23, 95% CI: 1.97–8.52, p &lt; 0.001, respectively).ConclusionThe prevalence of carotid atherosclerosis was shown to be very high in the high-risk stroke population. Specific SNPs, interactions among them, and carotid atherosclerosis were independently associated with a higher risk of ischemic stroke and other vascular events.
Dollar store policy opportunities in Baltimore City: community member and policy maker perspectives
Authors: Sundermeir Samantha M. , Santos Sydney R. , Lewis Emma C. , John Sara , Gardner Karen , Friedman Emily , Poirier Lisa , Hua Shuxian , Peoples-Brown Sevetra , Benjamin-Neelon Sara E. , Gittelsohn Joel 
Published: May 2024

IntroductionThere are currently over 50 dollar stores in Baltimore City, Maryland. Community perceptions of over-saturation and resulting neighborhood impacts have garnered recent attention. A Maryland State Senate Bill required further study of dollar stores in Baltimore City to inform future policy. Therefore, the over-arching goal of this study was to generate community-informed policy recommendations for the Baltimore City Council.MethodsThree methods of data collection were used: (1) in-depth interviews with community members, retail staff/owners, dollar store staff, and policy makers; (2) an online survey of Baltimore City residents; and (3) workshop with community members and one with policy makers. Triangulation across data sources, discussion amongst the research team, and member checking were used to generate the top four policy options: a conditional use ordinance, a community benefits agreements, a dispersal ordinance, and a staple foods ordinance.ResultsThere was strong support for policies that encourage dollar stores to better align with community priorities (e.g., improving store cleanliness and appearance, increasing availability of healthy foods), as opposed to closing or banning dollar stores entirely. There was also strong support for policies that would empower communities to participate in determining the role of dollar stores in their neighborhoods, for example through a conditional use ordinance or community benefits agreement. Key concerns included policy enforcement, given the additional funding required, and current limited capacity at the city government level. Strategies to address such challenges were generated including implementing business licenses at the city level, linking new ordinances to dollar store leases and permits, and encouraging dollar store participation in federal and local programs to more feasibly stock healthier food items (e.g., fresh produce). Dissatisfaction was expressed regarding a lack of policy options to address the existing dollar stores, not just new dollar stores entering the City.DiscussionThis study is the first of its kind to assess community support for dollar store policies at the local level, and serves to inform policies that improve dollar stores. A report of these findings was provided to Baltimore City Council to inform new, community-supported dollar store policies.
Neratinib, a pan ERBB/HER inhibitor, restores sensitivity of PTEN-null, BRAFV600E melanoma to BRAF/MEK inhibition
Authors: DuBose Evan , Bevill Samantha M. , Mitchell Dana K. , Sciaky Noah , Golitz Brian T. , Dixon Shelley A. H. , Rhodes Steven D. , Bear James E. , Johnson Gary L. , Angus Steven P. 
Published: May 2024

IntroductionApproximately 50% of melanomas harbor an activating BRAFV600E mutation. Standard of care involves a combination of inhibitors targeting mutant BRAF and MEK1/2, the substrate for BRAF in the MAPK pathway. PTEN loss-of-function mutations occur in ~40% of BRAFV600E melanomas, resulting in increased PI3K/AKT activity that enhances resistance to BRAF/MEK combination inhibitor therapy.MethodsTo compare the response of PTEN null to PTEN wild-type cells in an isogenic background, CRISPR/Cas9 was used to knock out PTEN in a melanoma cell line that harbors a BRAFV600E mutation. RNA sequencing, functional kinome analysis, and drug synergy screening were employed in the context of BRAF/MEK inhibition.ResultsRNA sequencing and functional kinome analysis revealed that the loss of PTEN led to an induction of FOXD3 and an increase in expression of the FOXD3 target gene, ERBB3/HER3. Inhibition of BRAF and MEK1/2 in PTEN null, BRAFV600E cells dramatically induced the expression of ERBB3/HER3 relative to wild-type cells. A synergy screen of epigenetic modifiers and kinase inhibitors in combination with BRAFi/MEKi revealed that the pan ERBB/HER inhibitor, neratinib, could reverse the resistance observed in PTEN null, BRAFV600E cells.ConclusionsThe findings indicate that PTEN null BRAFV600E melanoma exhibits increased reliance on ERBB/HER signaling when treated with clinically approved BRAFi/MEKi combinations. Future studies are warranted to test neratinib reversal of BRAFi/MEKi resistance in patient melanomas expressing ERBB3/HER3 in combination with its dimerization partner ERBB2/HER2.
Global research trends in immunotherapy for non-small cell lung cancer patients with KRAS mutations: a bibliometric analysis
Authors: Shen Hanyu , Li Chunxiao 
Published: May 2024

BackgroundImmunotherapy, frequently combined with conventional chemotherapy, is crucial for treating NSCLC. Kirsten rat sarcoma virus (KRAS) is a poor prognostic factor in patients with NSCLC, particularly lung adenocarcinoma, where binding of conventional inhibitors to mutated KRAS proteins is challenging. Field profiles, research hotspots, and prospects for immunotherapy for patients with NSCLC-carrying KRAS mutations were uncovered in this study.MethodsMicrosoft Excel 2019, Bibliometrix, VOSviewer software, and Citespace were utilized to conduct a comprehensive scientometric analysis and understand a specific research field's knowledge base and frontiers aided by bibliometrics.ResultsBetween 2014 and 2023, 398 eligible documents in the English language were acquired using the WoSCC database, of which 113 and 285 were reviews and articles, respectively. The growth rate per year was 34.25 %. The most cited articles were from the United States, and China published the highest number of articles. Cancers was the journal, with increased publications in recent years. The keywords with the strongest citation bursts were analyzed using Citespace. "Immune checkpoint inhibitors," "co-occurring genomic alterations," and "KRAS" are among the research hotspots in this field.ConclusionUsing bibliometric and visual analyses, we examined immunotherapy for patients with KRAS-mutant NSCLC over the previous decade. The whole analysis showed a steady, quick increase in yearly publications in this area. Our findings will provide a roadmap for future research on the mechanisms of immunotherapy and immune checkpoint inhibitor action in treating KRAS-mutant NSCLC.
Exploring the therapeutic potential of “Xiaochaihu Decoction”: a systematic review and meta-analysis on the clinical effectiveness and safety in managing cancer-related fever
Authors: Bu Zhijun , Xu Yaoyu , Zhou Xian , Wang Xuefeng , Liu Shuyuan , Wang Linyan , Yang Bei , Zhou Xiaodie , Lu Guanhang , Liu Jianping , Liu Zhaolan 
Published: May 2024

Objective: This study aimed to conduct the first meta-analysis to comprehensively evaluate the clinical effectiveness and safety of Xiaochaihu Decoction in treating Cancer-related Fever (CRF).Methods: Eight databases were systematically searched in September 2023. The risk of bias (ROB) 2.0 tool recommended by Cochrane Handbook was applied to evaluate the ROB of the included randomized controlled trials (RCTs). Additionally, the quality of evidence was assessed using the Grading of recommendations assessment, development and evaluation (GRADE) tool.Results: We included 18 RCTs involving 1,424 patients. Compared to Western medicine or Xinhuang Tablets, Xiaochaihu Decoction significantly improved clinical effectiveness in CRF patients (risk ratio [RR] = 1.24, 95% confidence interval [CI]: 1.17, 1.32) and expedited the normalization of body temperature (mean difference [MD] = −5.29, 95%CI: −5.59, −4.99). It also demonstrated a reduction in tumor necrosis factor-α (TNF-α) levels (MD = −0.63, 95%CI: −0.84, −0.41) and an increase in IL-2 levels (MD = 1.42, 95%CI: −1.09, 1.74). Analysis of Karnofsky Performance Status (KPS) scores showed that the use of Xiaochaihu Decoction improved the quality of life in CRF patients (RR = 1.57, 95%CI: 1.11, 2.22) and reduced the incidence of adverse events. However, it is important to note that the majority of included studies showed “some concerns” in risk of bias based on ROB 2.0, and the evidence quality assessed by GRADE method was rated as “low”.Conclusion: While this study suggests the clinical effectiveness and safety of Xiaochaihu Decoction in treating patients with CRF, confirming these findings will necessitate additional high-quality, large-scale RCTs in future research.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/, identifier CRD42023484068.