bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategi Komunikasi Pencegahan COVID-19 Pada Institusi Pendidikan Berbasis Pesantren
Authors: Marantika Nurhana , Gunawan Rivaldo Dimas , Asy'ari Nur Aini Shofiya 
Published: May 2024

Penelitian ini bertujuan untuk menganalisis strategi komunikasi Satgas PMDG dalam mencegah penyebaran COVID-19 di PMDG kampus 2. Teori yang digunakan adalah strategi komunikasi menurut Anwar Arifin. Penelitian ini menggunakan metode kualitatif deskriptif. Pengumpulan data dilakukan dengan teknik observasi, wawancara semistruktur dan studi dokumentasi. Pada tahap wawancara, peneliti mewawancarai Ketua Satgas COVID-19, Ketua Tim Protokol Kesehatan, dan Ketua Bagian Kesehatan. Teknik analisis data menggunakan cara data reduction, data display, dan conclusion drawing/ verification. Hasil penelitian menunjukkan bahwa Satgas COVID-19 PMDG melakukan langkah komunikatif yaitu, (1) Mengenal Khalayak: Respon santri negatif terhadap informasi COVID-19, mengenal karakteristik santri yang sopan, taat dan beradab sebagai komunikan dan memilih waktu malam hari dalam berkomunikasi. (2) Menyusun pesan: menentukan isi pesan yang bermakna positif, memilih Bahasa Indonesia sebagai medium penyampaian pesan, membuat simbol tagar sebagai dan simbol protokol, memuat pengarahan dalam pesan untuk memenuhi kebutuhan kesehatan kesehatan. (3) Menetapkan metode: merepetisi himbauan protokol kesehatan, memanfaatkan senioritas santri dalam penyampaian pesan, memperbaharui informasi COVID-19 secara berkala, mempersuasi santri agar menyampaikan gejala penyakit yang dialami dan membuat sistem reward dan punishment. (4) Penggunaan media: menghimbau protokol kesehatan melalui siaran Bagian Penerangan, penempelan poster COVID-19 di mading santri dan terakhir melalui media audiovisual yaitu video senam sehat dan protokol kesehatan.
Kohesivitas Kelompok Suporter Bola (Studi Kasus Muharrik Mania dalam Mendukung Gontor FC)
Authors: Rukmini Diah , Althof Mohammad Abiyyu , Ashari Maulana 
Published: May 2024

Penelitian ini dilatar belakangi tentang sepak bola yang merupakan olahraga dengan peminat terbanyak di dunia. Penelitian ini membahas tentang dinamika kelompok suporter dikalangan pesantren terkhusus Pondok Modern Darussalam Gontor 1 yaitu Muharrik mania. Dengan perbedaan latarbelakang karakter, sosial dan budaya, Muharrik mania mampu menjaga kohesivitas dalam kelompok. Untuk itu peneliti tertarik melakukan penelitian guna melihat pembentukan kohesivitas tersebut dari sudut pandang ilmu komunikasi. Penelitian ini dilandasi oleh teori Berfikir Kelompok (Groupthink) karya Irvin L. Janis dengan tiga asumsinya yaitu tingkat kohesivitas, proses pemecahan masalah dan sifat dasar mayoritas kelompok. Fokus penelitian ini, pada tingkat kohesivitas kelompok Muharrik mania untuk mengungkap tingkat kohesivitas yang terjadi pada kelompok suporter dalam mendukung Gontor Fc melalui empat pendekatan yaitu Social Cohesion, Task Cohesion, Perceived Cohecion, dan Emotion Cohecion. Metode yang digunakan dalam penelitian ini adalah kualitatif deskriptif yang diperoleh dari hasil wawancara, observasi dan dokummentasi. Hasil penelitian ini menunjukkan bahwa dari Social Cohesion, kelompok Muhrrik mania selalu berinteraksi baik dengan sesama anggota, dan menjujung nama baik kelompok, hal tersebut merupakan salah satu cara untuk membangun kohesivitas kelompok. Dari segi Task Cohesion, peran anggota dan keaktifan dalam kegiatan juga berpengaruh pada tingkat kohesivitas kelompok. Perceived Cohecion, perasaan yang muncul karenasetiap anggota memiliki tujuan sama, dan menganggap diri mereka sebagai bagian dari kelompok. Dan Emotion Cohecion, dengan berupaya meningkatkan empati anggota kelompok dengan tujuan meningkatkan emosional positif dalam kelompok. Hasil inilah yang meningkatkan kohesivitas kelompok Muharrik mania, sehingga menjadikan kelompok yang solid.
Granulites of the Larba Block of the Dzhugdzhur–Stanovoi Superterrane: Reconstruction of the Formation Conditions
Authors: Baltybaev Sh.K. , Dolivo-Dobrovolsky D.V. , Yurchenko A.V. , Volkova Yu.R. , Malchushkin E.S. 
Published: May 2024

Abstract
—We discuss the rocks of the Larba granulite block in the Ilikan zone of the Dzhugdzhur–Stanovoi superterrane. The Larba block is dominated by basic schists and garnet–biotite–orthopyroxene and garnet–biotite–cordierite–sillimanite gneisses (metabasites and metapelites). Calculation of temperatures and pressures of mineral formation was carried out by multi-equilibrium geothermobarometry, which makes it possible to evaluate the degree of equilibrium of mineral compositions along with P–T parameters. The P–T estimates have shown metamorphism of aluminous gneisses under moderate-pressure granulite facies conditions (7–8 kbar, 800–850 °C). Orthopyroxene granulites formed under granulite-amphibolite transition facies conditions. The mineral compositions and parageneses in highly ferrous metabasites permitted estimation of the conditions of metamorphism, P = 4–5 kbar and T = 630–700 °C, and show no influence of earlier granulite facies metamorphism. The bimodal P–T distribution for most samples of aluminous gneisses most probably reflects progressive and near-peak conditions of granulite metamorphism. The time of enderbite magmatism is determined from the upper intercept of discordia with concordia at 2546 ± 52 Ma and should be verified. The age of metamorphic rims over enderbite zircon is 1882 ± 11 Ma. The model Nd age of enderbites, TNd(DM) = 2.57–2.58 Ga, is close to the age of the core of enderbite zircon and differs significantly from the model Nd age of the host metamorphic rocks (2.8–3.0 Ga). The Paleoproterozoic metamorphism of the Larba block rocks regionally coincides with the third stage of collisional granitoid magmatism of the southeastern Siberian craton and records the formation of this structure.
Joint modeling of genomic and exposomic data reveals a substantial GxE component in type 2 diabetes etiology
Authors: Akhtari Farida S. , Tong Xiaoran , House John S. , Burkholder Adam , Fargo David C. , Schmitt Charles P. , Hall Janet E. , Motsinger-Reif Alison A. 
Published: May 2024

Abstract

Understanding the relative contribution of genetic and environmental factors and their interactions is important in mapping complex diseases. We integrated genomic data with unprecedented questionnaire-based exposure data from the Personalized Environment and Genes Study (PEGS) to dissect the etiology of type 2 diabetes and two exemplar traits, namely height and BMI. We estimated the phenotypic variance for type 2 diabetes contributed by the genome, exposome, and their interactions (50.96%, 2.80%, and 18.36%, respectively). The results demonstrate the utility of incorporating exposomic data and considering gene-environment interactions when seeking insights into the causes of common, complex diseases.
Expanding the Pragmatic Lens in Implementation Science: Why Stakeholder Perspectives Matter
Authors: Boulton Richard , Semkina Antonina , Jones Fiona , Sevdalis Nick 
Published: May 2024

Abstract

Background
Pragmatism is important in implementation science to ensure that implementation methods reflect the practical concerns of the stakeholders and services involved in change. To evaluate the usability of these methods, pragmatic measures have been developed using psychometrics. However, existing approaches have predominantly inherited a definition of pragmatism from the evidence-based healthcare movement. These metrics may not reflect concerns with pragmatism that public stakeholders (defined as those with expertise by experience of healthcare systems) may have with implementation science.
Aims
Consequently, our aim was to carry out participatory research to explore stakeholder views of pragmatic measures in implementation science theory.
Methods
We convened a working group of eight stakeholders. To facilitate discussion, we created educational materials, including a video and flyer. The working group conducted three meetings, engaging in abductive analysis to investigate the presented issues.
Results
Stakeholders expressed concerns about the restricted definition of pragmatism, the potential for biases in measurement, and the necessity for a holistic, pluralistic approach that incorporates diverse perspectives when developing and evaluating implementation theory and metrics. These findings underscore the risk of distorting the development of implementation science methods without the input and scrutiny of stakeholders. Neglecting the wider application of pragmatic philosophy in implementation science could limit stakeholder involvement in the design of implementation methods and service transformation.
Conclusions
This study, guided by experts with lived experience in healthcare services, opens doors for considering pragmatic philosophy in the evolution of pragmatic implementation measures and metrics, offering numerous promising directions for further exploration.
Cohort study of prediction of venous thromboembolism in emergency department patients with extremity symptoms.
Authors: Gottsäter Anders , Ekelund Ulf , Melander Olle , Björkelund Anders , Ohlsson Bodil 
Published: May 2024

Abstract

Despite diagnostic algorithms, the best pathway to identify venous thromboembolism (VTE) in emergency departments (ED) needs to be defined. We evaluated symptoms, background, and laboratory data in 27,647 ED patients presenting with pain, swelling, or other symptoms from the extremities, and identified predictors of VTE diagnosis within one year. Predictors of a clinical decision to perform phlebography, ultrasound, or computer tomography (CT) angiography of pelvic, lower, or upper extremity veins, CT of pulmonary arteries, or pulmonary scintigraphy at the ED or within 30 days, and the results of such investigations were also evaluated.
A total of 3,195 patients (11.6%) were diagnosed with VTE within one year. In adjusted analysis of patients in whom all laboratory data were available, a d-dimer value ≥0.5 mg/l (odds ratio [OR]: 2.602; 95% confidence interval [CI]: 1.894-3.575; p<0.001) at the ED and a previous diagnosis of VTE (OR: 6.037; CI: 4.465-8.162; p<0.001) independently predicted VTE. Of diagnosed patients, 2,355 (73.7%) had undergone imaging within 30 days after the ED visit and 1,730 (54.1%) were diagnosed at this examination. Lower age (OR: 0.984; CI: 0.972-0.997; p=0.014), higher blood hemoglobin (OR: 1.023; CI: 1.010-1.037; p<0.001), C-reactive protein (OR: 2.229; CI: 1.433-3.468; p<0.001), d-dimer (OR: 8.729; CI: 5.614-13.574; p<0.001), and previous VTE (OR: 7.796; CI: 5.193-11.705; p<0.001) predicted VTE on imaging.
In conclusion, analysis of 27,647 ED patients with extremity symptoms confirmed the importance of well-established risk factors for VTE. Many patients developing VTE within one year had initial negative imaging, highlighting the importance of continued symptom vigilance.
Updating the assessment of climate change impact on temperature at decadal scale and consolidating with CMIP6 future projections
Authors: Molina M.O. , Soares PMM , Lima MM , Gaspar T.H. , Lima DCA , Ramos A.M. , Russo A. , Trigo R. 
Published: May 2024

Abstract

The time evolution of climate change at the continental scale is provided in this study for present and future periods.
Climate spatio-temporal variability for each continent is studied by evaluating the decadal frequency distributions of monthly 2-m temperature anomalies for the 1951-2020 historical and 2015-2100 future periods. To achieve this, monthly averaged daily temperature data from ERA5 and an ensemble of CMIP6 GCMs, following a range of future climate scenarios (SSP1-2.6, SSP2-4.5, SSP3-7.0, and SSP5-8.5), are used.
The results of ERA5 show a decadal shift in the mean temperature anomalies towards warmer values at a continental scale, much more pronounced in the last decade (2011-2020), and larger in summer than in winter. It is seen that the CMIP6 GCM ensemble can reproduce this historical warming, at a climatological timescale, with a large degree of agreement for all continents. Furthermore, climate projections strongly indicate that this warming will continue under any climate change scenario and will be larger by the end of the century.
The two most likely scenarios (SSP2-4.5 and SSP3-7.0) show significant evidence that extremely hot temperatures (anomalies of more than three standard deviations (3$\sigma$) warmer than the climatology of the 1951–1980 base period) will become the normal climate in Africa and South America regions for the 2071-2100 period. In this work, it is seen that the regional mean temperature anomalies will increase in weak, moderate and strong forcing scenarios, reaching climatic extremes with expected major implications on the water cycle, agriculture, ecosystems, society and human health
FATS inhibits the Wnt pathway and induces apoptosis through degradation of MYH9 and enhances sensitivity to paclitaxel in breast cancer
Authors: Zhang Jun , song jinxuan , Wang Yue , Hua Zhipeng , Hu Linfei , Huang Yue , Tian Mengran , Qiu Li , Liu Hong 
Published: May 2024

Abstract

Breast cancer is one of the most prevalent and diverse malignancies, and, with global cases increasing, the need for biomarkers to inform individual sensitivity to chemotherapeutics has never been greater. Our retrospective clinical analysis predicted that the expression of the fragile site-associated tumor suppressor (FATS) gene was associated with the sensitivity of breast cancer to neoadjuvant chemotherapy with paclitaxel. In vitro experiments subsequently demonstrated that FATS significantly increased the inhibitory effects of paclitaxel on breast cancer cells’ migration, growth, and survival. An interaction screen revealed that FATS interacted with MYH9 and promoted its degradation via the ubiquitin-proteasome pathway, thereby downregulating Wnt signaling. By overexpression of FATS and MYH9, we demonstrated that FATS enhanced paclitaxel-induced apoptosis in breast cancer cells by degrading MYH9 to downregulate the Wnt pathway. We also demonstrated in a mouse xenograft model that FATS significantly increased the chemosensitivity of breast cancer cells to paclitaxel in vivo. This study presents a new mechanism by which FATS interacts with MYH9 to suppress the Wnt/β-catenin signaling pathway and induce apoptosis, thus enhancing the sensitivity of breast cancer cells to paclitaxel chemotherapy. The results also propose novel biomarkers for predicting breast cancer sensitivity to neoadjuvant chemotherapy with paclitaxel. Finally, we provide in vivo evidence that the combination of paclitaxel with IWR-1, a novel Wnt pathway inhibitor, synergistically suppresses breast cancer growth, laying the foundation for future trials with this drug combination. These results therefore provide a number of potential solutions for more precise treatment of patients with breast cancer in the future.
An Experimental Study on the Failure Mechanism of Load Distributive Compression Anchors in Residual Soil
Authors: Jo Bum-Hee , Chung Choong-Ki , Shin Gyu-Beom 
Published: May 2024

Abstract

The use of Load Distribution Compression Anchors (LDCAs), known for their high bearing capacity and removable strands after construction, has grown recently. Unlike conventional anchors, LDCAs have multiple anchor bodies along their length, presenting unique pull-out behaviors that remain insufficiently understood. This study aimed to investigate the failure mechanisms of LDCAs through physical model tests conducted in residual soil with a 90% relative density, adjusting variables such as anchor length, the number of anchor bodies, and the spacing between these bodies. To assess the effect of the surrounding soil on these mechanisms, the results of the experiment were compared with those from experiments conducted at a 70% relative density. Findings revealed that anchor body-grout tensile failure occurred during the initial loading stage. The tensile failure was determined by the grout strength itself rather than the effect of the surrounding soil. After anchor body-grout tensile failure, each anchor body behaves independently. However, when the spacing between the anchor bodies was small, local grout-ground interface failure occurred at both 70% and 90% relative density conditions, resulting in the overlapping of grout axial loads. Lastly, it was confirmed that the ultimate bearing capacity of LDCAs (multiple anchor bodies) can be less than that of compression-type anchors (single anchor body). The shear field developed by each anchor body in LDCAs overlapped and reduced the grout-ground shear strength. The reduction in ultimate bearing capacity was more pronounced in the dense soil condition and narrow anchor body spacing condition.
Photosynthesis drives methane production in a coccolithophorid, creating a negative feedback for carbon sequestration.
Authors: Gao Kunshan , Rao Yuming , Gao Guang , Berman-Frank Ilana , Bižić Mina 
Published: May 2024

Abstract

Phytoplankton produces methane (CH4), a potent greenhouse gas. Little is known about the relationship between their CH4 production and photosynthesis, the predominant biological pathway of CO2 sequestration in the ocean. We show that CH4 released by the widespread, bloom-forming marine microalga Emiliania huxleyi grown under different light levels correlated positively with photosynthetic electron transfer and carbon fixation. We ruled out the possibility of classical methanogenesis in the cultures and showed that under saturating light E. huxleyi produces CH4 at a maximal rate of about 6.6 ×10− 11 µg CH4 cell− 1 d− 1 or 3.9 µg CH4 g− 1 particulate organic carbon d− 1, and cannot generate CH4 in darkness. Accounting for the CH4 released vs CO2 fixed, the stronger global warming potential of CH4, and estimates of CO2 that reaches the ocean interior, we conclude that E. huxleyi’s contribution to the marine biological carbon pump may be attenuated by up to 13% due to its CH4 release.
Towards the Assessment of Subjective Financial Distress due to a Tumor Disease. A Conceptual Model of the Financial Effects of Cancer on Patients in Germany
Authors: Pauge Sophie , Züger Andrea , Richter Luise , Mathies Viktoria , Surmann Bastian , Ernst Thomas , Menold Natalja , Greiner Wolfgang , Winkler Eva C , Mehlis Katja 
Published: May 2024

Abstract

Purpose A conceputalisation of subjective financial distress as a consequence of a cancer diagnosis and treatment is still missing due to a lack of a comprehensive model accounting for all relevant dimensions of financial effects of cancer experienced by patients. Our goal was to derive a model for the German healthcare system to shed light on the complex process of financial effects of cancer.
Methods The model was developed through systematic literature review and qualitative studies, including inter-views with 18 cancer patients and a focus group with 4 social services representatives. The iterative process of model development was accompanied by an ongoing exchange in the interdisciplinary research team.
Results The developed model of financial effects of cancer experienced by patients consists of three dimensions: 1) actual and anticipated financial disadvantages, 2) behavioural and cognitive coping strategies, and 3) subjective financial distress conceptualised as negative effects in different aspects of daily living: employment, living situation, family, social participation, health promoting lifestyle, additional personally preferred treatments, navigating the health system and a further area so-called unspecific.
Conclusion Subjective financial distress is driven by different financial effects of cancer experienced by patients and is perceived as negative in various aspects of daily living. While the identified categories of daily living can be observed in countries with universal healthcare coverage, the content and degree of each subcategory depends on country-specific characteristics. The introduced model can be used to inform the development of a new PROM.
Trial registration number NCT05319925 (regristration date: 2022-06-01)
Realization of a three-dimensional photonic higher-order topological insulator
Authors: Gao Zhen , Wang Ziyao , Meng Yan , Yan Bei , Zhao Dong , Yang Linyun , Chen Jingming , Cheng Minqi , Xiao Tao , Shum Perry Ping , Liu Gui-Geng , Yang Yihao , Chen Hongsheng , Xi Xiang , Zhu Zhenxiao , Xie Biye 
Published: May 2024

Abstract

The discovery of photonic higher-order topological insulators (HOTIs) has significantly expanded our understanding of band topology and provided unprecedented lower-dimensional topological boundary states for robust photonic devices. However, due to the vectorial and leaky nature of electromagnetic waves, it is challenging to discover three-dimensional (3D) topological photonic systems and the realization of photonic HOTIs has so far still been limited to two dimensions (2D). Here, we report on the first experimental realization of a 3D Wannier-type photonic HOTI in a tight-binding-like metal-cage photonic crystal, whose band structure matches well with that of a 3D tight-binding model due to the confined Mie resonances. By microwave near-field measurements, we directly observe coexisting topological surface, hinge, and corner states in a single 3D photonic HOTI, as predicted by the tight-binding model and simulation results. Moreover, we demonstrate that all-order topological boundary states of the 3D photonic HOTIs are self-guided even in the light cone continuum and can be exposed to air without ancillary cladding, making them well-suited for practical applications. Our work opens new avenues to the multi-dimensional robust manipulation of electromagnetic waves at the outer surfaces of 3D cladding-free photonic bandgap materials and may find novel applications in 3D topological integrated photonics devices.
The Impact of Mining Activities on the Sleep Quality of Adjacent Residential Areas (Case Study: Gold Mine)
Authors: Farnia Kiana Afshar , Dehghani Hesam , Khajevandi Ali Asghar , Ashtari Pedram 
Published: May 2024

Abstract

Sleep, as a complex neural state, is crucial for restoring the body's energy levels and encouraging rest. Few studies have investigated the effects of mining on mental health, especially on the quality of sleep in residential areas near mines. This study seeks to identify these effects and consequences as thoroughly as possible. External physical factors can influence sleep patterns, leading to disturbances that manifest as sleep disorders. Sleep disorders are prevalent clinical issues, adversely affecting overall health, safety, and quality of life by disrupting natural sleep patterns. Inadequate or non-restorative sleep can disrupt normal physical, mental, social, and emotional functioning. The primary approach to addressing sleep disorders involves identifying their root causes and dealing with the associated conditions. This study explores sleep disorders arising from mining activities, focusing on the impact of explosions on residents near gold mines in Iran. Conducted over one month, the research aimed to assess sleep quality using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. After collecting data through this standardized questionnaire, analysis was conducted using SPSS26 and Mplus softwares. Results from the questionnaire analysis revealed that 72.5% of individuals residing in the mining area reported experiencing sleep disorders. Significant differences in PSQI indices between men and women were identified, suggesting that women in the studied rural area perceived mining activities as significantly impacting their sleep quality and daily functioning. Furthermore, no significant differences were observed in sleep quality indices between singles and married participants, except for the use of sleep-inducing medications among employed and unemployed groups in the study community. Noteworthy, many workers, particularly those from the rural male population employed in mining, face various harmful factors such as explosions and noise, potentially contributing to the impact of mining on residents in the area. The study results can inform the development of effective strategies to mitigate the negative consequences of mining.