bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does in vitro hemolysis affect measurements of plasma apixaban concentration by UPLC‐MS and anti‐Xa assay?
Authors: Røed‐Undlien Henriette , Schultz Nina Haagenrud , Amundsen Erik Koldberg , Wollmann Birgit M. , Molden Espen , Akerkar Rupali R. , Bjørnstad Johannes Lagethon 
Published: May 2024

AbstractIntroductionHemolytic interference may impact various laboratory tests, including coagulation analyses. Apixaban is the most commonly used direct oral anticoagulant in Norway, and there is lacking knowledge on how apixaban concentration measurements might be influenced by hemolysis. Moreover, hemolysis‐induced alterations in apixaban levels could potentially impact the risk of bleeding in specific clinical scenarios. We wanted to study whether hemolysis would increase apixaban concentration and investigate the impact of hemolytic interference on apixaban concentration measurements.MethodsBlood samples from 20 apixaban‐treated patients and 8 healthy controls were hemolyzed in vitro by a freeze method. The degree of hemolysis was measured with plasma free hemoglobin (PfHb) at baseline and two levels of hemolysis. Apixaban concentration was measured in plasma using both the chromogenic anti‐Xa method and the ultraperformance liquid chromatography mass spectrometry (UPLC‐MS). Thrombin generation assay was performed to assess coagulability.ResultsUPLC‐MS measurements showed a mean concentration change of −1.66% (±3.2%, p = 0.005) and anti‐Xa assay showed a mean concentration change of 3.37% (±6.5%, p = 0.09) with increasing hemolysis. Thrombin generation lagtime decreased, and endogenous thrombin potential and peak thrombin increased with increasing hemolysis in both the control group and the apixaban group.ConclusionApixaban concentration measurements by anti‐Xa assay and UPLC‐MS were not affected by hemolysis to a clinically relevant extent. Furthermore, hemolysis did not lead to hypocoagulability when assessed by thrombin generation.
TH1L involvement in colorectal cancer pathogenesis by regulation of CCL20 through the NF‐κB signalling pathway
Authors: Wang Shaochang , Sun Yujing , Li Chunya , Chong Yueyang , Ai Meihong , Wang Yanxia , Shi Haiyun , Shang Yu 
Published: May 2024

AbstractTH1L (also known as NELF‐C/D) is a member of the Negative Elongation Factor (NELF) complex, which is a metazoan‐specific factor that regulates RNA Polymerase II (RNAPII) pausing and transcription elongation. However, the function and molecular mechanisms of TH1L in cancer progression are still largely unknown. In this study, we found that TH1L was highly expressed in colorectal cancer (CRC) tissues and the faeces of CRC patients. Overexpression of TH1L significantly enhanced the proliferation and migration of CRC cells, while its knockdown markedly suppressed these processes. In mechanism, RNA sequencing revealed that CCL20 was upregulated in TH1L‐overexpressed CRC cells, leading to activation of the NF‐κB signalling pathway. Rescue assays showed that knockdown of CCL20 could impair the tumour‐promoting effects of THIL in CRC cells. Taken together, these results suggest that TH1L may play a vital role via the CCL20/NF‐κB signalling pathway in CRC proliferation and migration and may serve as a potential target for diagnosis and therapy of CRC.
Larger yellow‐phase Japanese eels show short‐range homing in a freshwater river
Authors: Mitamura Hiromichi , Takagi Junichi , Itaya Yoshimi , Watanabe Shun , Kume Manabu 
Published: May 2024

AbstractThe homing behavior and site fidelity to habitats in various fishes, including anguillid eels (genus Anguilla), are fascinating. However, little is known about how yellow‐phase eels exhibit homing behavior and the sensory mechanisms involved. Using acoustic telemetry, we investigated the homing behavior of 18 Japanese eels, A. japonica, with total lengths ranging from 204 to 570 mm, in a narrow freshwater river in inland central Japan, where salinity gradient, tidal current, and magnetic sense cannot be used for their homing, but where olfaction could play a role. The tagged eels captured upstream and downstream were released downstream and upstream, respectively. The results showed that large eels, over approximately 400 mm in total length, exhibited homing behavior to their original sampling locations (likely to shelters and foraging sites, where they probably spent a longer time than in other locations and grew successfully) from outside their home ranges, predominantly during the dark period. Homing success was not affected by the two capture locations, indicating that eels did not use olfactory cues for short‐range homing in freshwater rivers.
Self‐care rhetoric and institutional culpability: Theorizing the academy and intellectual labor
Authors: Cabaniss Emily R. , Davis Shannon N. , Parrotta Kylie L. 
Published: May 2024

AbstractSelf‐care, a ubiquitous concept commonly touted as the solution to an array of modern‐day problems, implies unapologetic selfishness aimed at preserving mental, emotional, and physical health. The overtly individualistic framing in its most common usage—the centering of oneself for the sake of oneself—obscures power relations and structural/institutional inequalities that create the need for self‐care. To deal with difficult work or family lives, taking up a hobby or some kind of diversion offers an escape that feels good; self‐care serves as a kind of coping mechanism, but not a solution to a social problem. It also lets society, or more specifically, managers and administrators in organizations, off the hook because it places the onus on individuals to deal with challenges on their own rather than situating them as social problems. We critique shortcomings in self‐care rhetoric employed by organizations—and specifically university administrators—to their members, by extending Hochschild's economy of gratitude framework.
Dental service utilization in the general adult population in Bangladesh
Authors: Pengpid Supa , Peltzer Karl 
Published: May 2024

AbstractObjectivesWith the help of a national community‐based survey, the analysis aimed to estimate the number of adults in Bangladesh who used dental services (DSU).MethodsThe 8185 participants (18–69 years old) in the Bangladesh cross‐sectional STEPS survey in 2018 provided national data for analysis. Predisposing, enabling, and need factors for DSU were included in the interview data, physical examinations, and biochemical analyses. To estimate the DSU (last 12 months) predictors, Poisson regression was employed.ResultsSeven out of 10 participants (71.0%) had never DSU, 13.2% within the past 12 months, and 15.9% more than 12 months ago. In terms of predisposing factors, the final model showed a negative relationship between past 12‐month DSU and living in the northern region (adjusted prevalence ratio‐APR: 0.75, 95% CI: 0.59, 0.96). The enabling factors of living in an urban area (APR: 1.19, 95% CI: 1.01, 1.41) and seeing a doctor or other healthcare provider within the previous year (APR: 1.37, 95% CI: 1.08, 1.74) were positively correlated with DSU. In terms of need factors, dental pain (APR: 15.37, 95% CI: 9.68, 24.40), multimorbidity (APR: 1.26, 95% CI: 1.02, 1.55), oral health impact (OHI) speech problem (APR: 1.35, 95% CI: 1.13, 1.63), and OHI felt tense (APR: 1.34, 95% CI: 1.10, 1.64) were positively associated with DSU.ConclusionsA low proportion of participants had DSU in the past 12 months and several associated factors were identified.
The IPTA Nashville consensus conference on post‐transplant lymphoproliferative disorders after solid organ transplantation in children: IV‐consensus guidelines for the management of post‐transplant lymphoproliferative disorders in children and adolescents
Authors: Allen Upton D. , L'Huillier Arnaud G. , Bollard Catherine M. , Gross Thomas G. , Hayashi Robert J. , Höcker Britta , Maecker‐Kolhoff Britta , Marks Stephen D. , Mazariegos George Vincent , Smets Francoise , Trappe Ralf U. , Visner Gary , Chinnock Richard E. , Comoli Patrizia , Danziger‐Isakov Lara , Dulek Daniel E. , Dipchand Anne I. , Ferry Judith A. , Martinez Olivia M. , Metes Diana M. , Michaels Marian G. , Preiksaitis Jutta , Squires James E. , Swerdlow Steven H. , Wilkinson James D. , Dharnidharka Vikas R. , Green Michael , Webber Steven A. , Esquivel Carlos O. 
Published: May 2024

AbstractThe International Pediatric Transplant Association convened an expert consensus conference to assess current evidence and develop recommendations for various aspects of care relating to post‐transplant lymphoproliferative disorders (PTLD) after pediatric solid organ transplantation. This report addresses the outcomes of deliberations by the PTLD Management Working Group. A strong recommendation was made for reduction in immunosuppression as the first step in management. Similarly, strong recommendations were made for the use of the anti‐CD20 monoclonal antibody (rituximab) as was the case for chemotherapy in selected scenarios. In some scenarios, there is uncoupling of the strength of the recommendations from the available evidence in situations where such evidence is lacking but collective clinical experiences drive decision‐making. Of note, there are no large, randomized phase III trials of any treatment for PTLD in the pediatric age group. Current gaps and future research priorities are highlighted.
Treatment outcome at the pediatric stem cell transplantation center in Syria: A single‐center experience
Authors: khudari Rawan Al , Doba Dalal , Esmandar Amjad , Kheder Maged 
Published: May 2024

AbstractBackgroundHematopoietic stem cell transplantation (HSCT) is a therapeutic approach known for its high success rates in treating various hematologic malignancies, hemoglobinopathies, immune deficiencies, and other disorders. Notably, pediatric HSCT commenced in Syria in 2021 amidst the prevailing crisis. This study aims to assess the demographic and clinical profiles of pediatric patients who underwent stem cell transplantation and to analyze treatment outcomes at Syria's inaugural pediatric HSCT center.MethodsThis study is a single‐center retrospective analysis of 25 pediatric patients who underwent HSCT underage of 14 years in the National Stem Cell Center (HAYAT) in Damascus within the period 2021–2023. The databases were created based on data that were collected from patient medical records.ResultsIn autologous patients, transplant‐related mortality (TRM) was 0%, with 4 (57%) experiencing disease relapse, resulting in the death of one patient. Additionally, 3 (42.8%) of patients remain alive under second‐line management. The overall survival rate was 6 (85.7%), and the disease‐free survival rate was 16 (88%). In allogeneic patients, TRM was 5.5% (1/18). One allogeneic patient experienced disease relapse and subsequently died. The overall survival rate and disease‐free survival rate were 16 (88%).ConclusionsThe objective of this study was to assess the outcomes of pediatric HSCT patients who have undergone transplantation thus far. Given the recent initiation of pediatric stem cell transplantation in Syria, our dataset provides a basis for comparison with international hematopoietic stem cell transplantation centers regarding treatment complications and outcomes, notwithstanding the challenges and crises faced within our country.
BK polyomavirus DNAemia, allograft rejection, and de novo donor‐specific antibodies after lowering target tacrolimus levels in pediatric kidney transplant recipients
Authors: Huang Hou‐Xuan , Xiang Yijin , George Roshan , Winterberg Pamela , Serluco Anastacia , Liverman Rochelle , Yildirim Inci , Garro Rouba 
Published: May 2024

AbstractBackgroundBK polyomavirus (BKV) DNAemia is a challenging infectious complication after kidney transplant (KT). Reduction of immunosuppression is the mainstay of management, and tacrolimus is often the first immunosuppressive medication adjusted upon the diagnosis of BKV DNAemia. This study aimed to evaluate the impact of a new institutional protocol with lower target tacrolimus levels on BKV DNAemia, allograft rejection, and de novo donor‐specific antibodies (dnDSA) among pediatric KT recipients.MethodsWe conducted a retrospective chart review of all KT episodes between January 2013 and December 2018. The new protocol with lower target tacrolimus levels was implemented in March 2015. One hundred twenty‐seven patients were included in primary analysis. All patients received induction with basiliximab and methylprednisolone and were maintained on a steroid‐based immunosuppressive regimen.ResultsIn the post‐intervention cohort, cumulative incidence of BKV DNAemia at 100 days (13.4% vs. 17.8%, p = .605) and 18 months post‐KT (34.1% vs. 26.7%, p = .504) was not significantly different from the pre‐intervention cohort. Biopsy‐proven rejection rate did not change. However, we observed a trend toward earlier development of dnDSA in the post‐intervention cohort using the Kaplan–Meier survival analysis (log‐rank p = .06). Younger recipient age at the time of transplant was found to slightly increase the risk of BKV DNAemia (OR: 1.09, 95% CI [1.01, 1.16], p = .024). There was an association between BKV DNAemia and biopsy‐proven rejection of any type (adjustedOR: 2.77, 95% CI [1.26, 6.23], p = .012), especially acute T‐cell‐mediated rejection grade 1A and above (adjustedOR: 2.95, 95% CI [1.06, 8.30], p = .037), after adjusted for recipient age at the time of transplant.ConclusionsTargeting lower tacrolimus levels did not decrease the incidence of BKV DNAemia within 100 days or 18 months post‐KT, nor did it increase the risk of biopsy‐proven rejection among pediatric KT recipients in our center. However, there was a trend toward earlier development of dnDSA, which may portend worse long‐term graft outcome post‐KT. Our findings highlight the need for individualized immunosuppressive regimens based on immunologic and infectious risk factors and the importance of implementing innovative biomarkers to guide therapy and improve outcomes.
Shamelessly Blue: Pitch Complexes and the Social Otherwise
Authors: Warmack Andrea Dionne 
Published: May 2024

AbstractEarly american Black Blueswomen—such as Ma Rainey, Alberta Hunter, Bessie Smith, Billie Holiday, and Nina Simone—perform Blues as a praxis that both critiques and transforms the ways in which american Black people were—and continue to be—excluded from the construct of the human subject. Merleau‐Ponty's account of inter‐subjectivity is predicated on his account of the human subject who is always‐already in a social milieu in which they are never taken for an object. Subjectivity is affirmed through the subject's ability to differentiate itself from objects via sight. In this way the human subject is sensorially, affectively, epistemically, and axiologically organized as eye‐forward. The human subject's ability to exceed objectification runs counter to the lived experiences of a number of precaritized peoples, specifically, american Black people. If being seen without being objectified is the lived experience of the subject, then subjectivity is an exclusive way‐of‐ being in the world. Rather than inhabit this exclusion from human subjectivity as a lack, american Black people—as is evidenced by Blues—create a social otherwise with distinct ways of living—not just surviving or enduring—created within, but not wholly determined by, the pornotrope or the wake. This paper begins to sound out a way that this social otherwise breathes life into its own socio‐ethical experience via a turn to the aural. This paper takes up Blues to explore what expressive and affective ways‐of‐ being in the world are possible with an ear‐forward sensorial organization.
Causal Models and Metaphysics – Part 1: Using Causal Models
Authors: McDonald Jennifer 
Published: May 2024

AbstractThis paper provides a general introduction to the use of causal models in the metaphysics of causation, specifically structural equation models and directed acyclic graphs. It reviews the formal framework, lays out a method of interpretation capable of representing different underlying metaphysical relations, and describes the use of these models in analyzing causation.
Retrospective evaluation of a right heart parameter score in the assessment of precapillary pulmonary hypertension in dogs (2017–2021): 135 cases
Authors: Gelé Rebecca R. , Burnotte Priscilla , Valcke Annelies , Walker Thomas G. , Kennedy Christopher R. , Merveille Anne‐Christine , Gommeren Kris 
Published: May 2024

AbstractObjectiveTo determine if emergency and critical care residents can identify moderate to severe precapillary pulmonary hypertension on cardiologist‐obtained cineloops using a pulmonary hypertension score (PHS) and report the interobserver variability of the PHS.DesignMulticenter, retrospective, case–control study from 2017 to 2021.SettingPrivate referral center and veterinary teaching hospital.AnimalsOne hundred and thirty‐five client‐owned dogs that underwent diagnostic echocardiography.InterventionsNone.Measurements and Main ResultsMedical records of dogs with stage B1 myxomatous mitral valve disease (MMVD) and dogs diagnosed with precapillary pulmonary hypertension (PCPH) via echocardiograms were reviewed. Dogs were categorized by a cardiologist into 5 groups (normal, B1 MMVD, mild, moderate, and severe PCPH) based on Doppler pulmonary pressure gradients and right heart morphology. Cineloops from each case were subjectively evaluated by emergency and critical care residents for the presence of right atrial and ventricular enlargement, right ventricular hypertrophy, interventricular septal flattening, and pulmonary artery and trunk enlargement to form a composite pulmonary hypertension score out of 8 (PHS8). When available, signs of peritoneal effusion and distention of the caudal vena cava were subjectively assessed to generate a pulmonary hypertension score out of 10 (PHS10). There was excellent discrimination of moderate to severe PCPH versus grouped absent to mild PCPH using PHS8 (area under the receiver operator curve [AUC] [95% confidence interval, CI] = 0.90 [0.84–0.95], P < 0.0001) and PHS10 (AUC [95% CI] = 0.89 [0.81–0.97], P < 0.0001). PHS8 ≥3 was 64% sensitive and 98% specific for moderate to severe PCPH (positive likelihood ratio [LR+] 32, negative likelihood ration [LR−] 0.37). PHS10 ≥ 3.3 was 64% sensitive and 92% specific for moderate to severe PCPH (LR+ 8, LR− 0.39). Interobserver agreement was good to excellent (intraclass correlation coefficient [ICC] = 0.74 [95% CI: 0.66–0.80], n = 135).ConclusionsResidents identified moderate to severe PCPH in dogs using PHS on cineloops previously obtained by a cardiologist. The interrater agreement was good to excellent with limited training. Prospective studies to determine if residents can obtain diagnostic images for PHS are warranted.
Epidemiologic and tick exposure characteristics among people with reported Lyme disease – Minnesota, 2011–2019
Authors: Earley Austin R. , Schiffman Elizabeth K. , Wong Karen K. , Hinckley Alison F. , Kugeler Kiersten J. 
Published: May 2024

AbstractAims and MethodsIn the United States, blacklegged Ixodes spp. ticks are the primary vector of Lyme disease. Minnesota is among the states with the highest reported incidence of Lyme disease, having an average of 1857 cases reported annually during 2011–2019. In contrast to the Northeast and mid‐Atlantic United States where exposure to ticks predominately occurs around the home, the circumstances regarding risk for exposure to blacklegged ticks in Minnesota are not well understood, and risk is thought to be highest in rural areas where people often participate in recreational activities (e.g. hiking, visiting cabins). We analysed enhanced surveillance data collected by the Minnesota Department of Health during 2011–2019 to describe epidemiologic and tick exposure characteristics among people with reported Lyme disease.ResultsWe found that younger age, male gender, residence in a county with lower Lyme disease risk, residence in the Minneapolis‐St. Paul metropolitan area, and an illness onset date later in the year were independently associated with higher odds of reporting tick exposures away from the home. We also describe the range of activities associated with tick exposure away from the home, including both recreational and occupational activities.ConclusionsThese findings refine our understanding of Lyme disease risk in Minnesota and highlight the need for heterogeneous public health prevention messaging, including an increased focus on peridomestic prevention measures among older individuals living in high‐risk rural areas and recreational and occupational prevention measures among younger individuals living in the Minneapolis‐St. Paul metropolitan area.
The Growth Effect of Foreign Direct Investment: Evidence from Time-Frequency Analysis
Authors: Touray Alfusainey 
Published: May 2024

The impact of FDI inflow on the economy of the host country had not been clearly defined, especially in the empirical literature. Most of the empirical results from past studies are distorted by model misspecification and endogeneity problems. To find a cure for these deficiencies, this study uses an unconventional methodology called wavelet coherence to examine the nexus between FDI inflows and per capita income growth in three African countries (The Gambia, Ghana, and Senegal. Wavelet coherence is a localized correlation in time-frequency space that examines the dynamic nexus between two time series. Most traditional econometric methods that were used to study the nexus between FDI inflows and income assumed that the series are stationary, however, most economic time series are not stationary, hence, this makes most traditional methods ineffective in finding the nexus between FDI and income. The use of wavelet coherence can overcome this challenge because it does not require the assumption of stationarity of the data.The empirical results of the study showed that the impact of FDI inflows depends on the degree to which the FDI is a complement or a substitute for domestic investment. Senegal where FDI complements domestic investment in enhancing growth derived more benefit from FDI inflows than The Gambia where FDI inflows substitute domestic investment and Ghana where FDI inflows had no impact on domestic investment. The causality between per capita income growth and per stock of FDI inflows runs from per stock of FDI inflows or the two series move together.