bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cohort Study of Somatostatin-Based Radiopeptide Therapy With [90Y-DOTA]-TOC Versus [90Y-DOTA]-TOC Plus [177Lu-DOTA]-TOC in Neuroendocrine Cancers
Authors: Villard Linda , Romer Anna , Marincek Nicolas , Brunner Philippe , Koller Michael T. , Schindler Christian , Ng Quinn K.T. , Mäcke Helmut R. , Müller-Brand Jan , Rochlitz Christoph , Briel Matthias , Walter Martin A. 
Published: March 2012

Purpose Radiopeptide therapy is commonly performed with a single radioisotope. We aimed to compare the effectiveness of somatostatin-based radiopeptide therapy with a single versus a combination of radioisotopes. Patients and Methods In a cohort study, patients with metastasized neuroendocrine cancer were treated with repeated cycles of 90yttrium-labeled tetraazacyclododecane-tetraacetic acid modified Tyr-octreotide ([90Y-DOTA]-TOC) or with cycles alternating between [90Y-DOTA]-TOC and 177lutetium-labeled DOTA-TOC ([177Lu-DOTA]-TOC) until tumor progression or permanent toxicity. Multivariable Cox regression and competing risk regression were used to study predictors of survival and renal toxicity in patients completing three or more treatment cycles. Results A total of 486 patients completed three or more treatment cycles; 237 patients received [90Y-DOTA]-TOC and 249 patients received [90Y-DOTA]-TOC + [177Lu-DOTA]-TOC. Patients receiving [90Y-DOTA]-TOC + [177Lu-DOTA]-TOC had a significantly longer survival than patients receiving [90Y-DOTA]-TOC alone (5.51 v 3.96 years; hazard ratio, 0.64; 95% CI, 0.47 to 0.88; P = .006). The rates of severe hematologic toxicities (6.3% v 4.4%; P = .25) and severe renal toxicity (8.9% v 11.2%; P = .47) were comparable in both groups. Conclusion [90Y-DOTA]-TOC + [177Lu-DOTA]-TOC was associated with improved overall survival compared with [90Y-DOTA]-TOC alone in patients completing three or more cycles of treatment. Contrary to the current practice in radiopeptide therapy, our results suggest an advantage of using a combination of radioisotopes.
The Novel Histologic International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Classification System of Lung Adenocarcinoma Is a Stage-Independent Predictor of Survival
Authors: Warth Arne , Muley Thomas , Meister Michael , Stenzinger Albrecht , Thomas Michael , Schirmacher Peter , Schnabel Philipp A. , Budczies Jan , Hoffmann Hans , Weichert Wilko 
Published: March 2012

Purpose Our aim was to analyze and validate the prognostic impact of the novel International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS) proposal for an architectural classification of invasive pulmonary adenocarcinomas (ADCs) across all tumor stages. Patients and Methods The architectural pattern of a large cohort of 500 patients with resected ADCs (stages I to IV) was retrospectively analyzed in 5% increments and classified according to their predominant architecture (lepidic, acinar, solid, papillary, or micropapillary), as proposed by the IASLC/ATS/ERS. Subsequently, histomorphologic data were correlated with clinical data, adjuvant therapy, and patient outcome. Results Overall survival differed significantly between lepidic (78.5 months), acinar (67.3 months), solid (58.1 months), papillary (48.9 months), and micropapillary (44.9 months) predominant ADCs (P = .007). When patterns were lumped into groups, this resulted in even more pronounced differences in survival (pattern group 1, 78.5 months; group 2, 67.3 months; group 3, 57.2 months; P = .001). Comparable differences were observed for overall, disease-specific, and disease-free survival. Pattern and pattern groups were stage- and therapy-independent prognosticators for all three survival parameters. Survival differences according to patterns were influenced by adjuvant chemoradiotherapy; in particular, solid-predominant tumors had an improved prognosis with adjuvant radiotherapy. The predominant pattern was tightly linked to the risk of developing nodal metastases (P < .001). Conclusion Besides all recent molecular progress, architectural grading of pulmonary ADCs according to the novel IASLC/ATS/ERS scheme is a rapid, straightforward, and efficient discriminator for patient prognosis and may support patient stratification for adjuvant chemoradiotherapy. It should be part of an integrated clinical, morphologic, and molecular subtyping to further improve ADC treatment.
Pertuzumab Monotherapy After Trastuzumab-Based Treatment and Subsequent Reintroduction of Trastuzumab: Activity and Tolerability in Patients With Advanced Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer
Authors: Cortés Javier , Fumoleau Pierre , Bianchi Giulia Valeria , Petrella Teresa M. , Gelmon Karen , Pivot Xavier , Verma Shailendra , Albanell Joan , Conte Pierfranco , Lluch Ana , Salvagni Stefania , Servent Veronique , Gianni Luca , Scaltriti Maurizio , Ross Graham A. , Dixon Joanna , Szado Tania , Baselga José 
Published: March 2012

Purpose The combination of pertuzumab and trastuzumab resulted in a clinical benefit rate (CBR) of 50% in patients with human epidermal growth factor receptor 2 (HER2) –positive breast cancer whose disease progressed during prior trastuzumab-based therapy. To define whether this previously observed encouraging activity was a result of the combination of pertuzumab and trastuzumab or of pertuzumab alone, we recruited a third cohort of patients who received pertuzumab without trastuzumab. We then investigated the impact of reintroducing trastuzumab to patients whose disease progressed on pertuzumab monotherapy. Patients and Methods Twenty-nine patients with HER2-positive breast cancer whose disease progressed during prior trastuzumab-based therapy received pertuzumab (840 mg loading dose, then 420 mg every 3 weeks) until progressive disease or unacceptable toxicity. Seventeen patients with disease progression continued to receive pertuzumab (at the same dose), with the addition of trastuzumab (4 mg/kg loading dose and then 2 mg/kg weekly or 8 mg/kg loading dose and then 6 mg/kg every 3 weeks). Results All 29 patients enrolled for pertuzumab monotherapy experienced disease progression. The objective response rate (ORR) and CBR were 3.4% and 10.3%, respectively, during pertuzumab monotherapy. With the addition of trastuzumab, the ORR and CBR were 17.6% and 41.2%, respectively. Progression-free survival was longer with combination therapy than pertuzumab monotherapy (17.4 v 7.1 weeks, respectively). Treatment was well tolerated with minimal cardiac dysfunction. Conclusion Although pertuzumab has some activity in patients with HER2-positive breast cancer that progressed during therapy with trastuzumab, the combination of pertuzumab and trastuzumab seems to be more active than monotherapy.
Identification of a Poor-PrognosisBRAF-Mutant–Like Population of Patients With Colon Cancer
Authors: Popovici Vlad , Budinska Eva , Tejpar Sabine , Weinrich Scott , Estrella Heather , Hodgson Graeme , Van Cutsem Eric , Xie Tao , Bosman Fred T. , Roth Arnaud D. , Delorenzi Mauro 
Published: March 2012

PurposeOur purpose was development and assessment of a BRAF-mutant gene expression signature for colon cancer (CC) and the study of its prognostic implications.Materials and MethodsA set of 668 stage II and III CC samples from the PETACC-3 (Pan-European Trails in Alimentary Tract Cancers) clinical trial were used to assess differential gene expression between c.1799T>A (p.V600E) BRAF mutant and non-BRAF, non-KRAS mutant cancers (double wild type) and to construct a gene expression–based classifier for detecting BRAF mutant samples with high sensitivity. The classifier was validated in independent data sets, and survival rates were compared between classifier positive and negative tumors.ResultsA 64 gene-based classifier was developed with 96% sensitivity and 86% specificity for detecting BRAF mutant tumors in PETACC-3 and independent samples. A subpopulation of BRAF wild-type patients (30% of KRAS mutants, 13% of double wild type) showed a gene expression pattern and had poor overall survival and survival after relapse, similar to those observed in BRAF-mutant patients. Thus they form a distinct prognostic subgroup within their mutation class.ConclusionA characteristic pattern of gene expression is associated with and accurately predicts BRAF mutation status and, in addition, identifies a population of BRAF mutated-like KRAS mutants and double wild-type patients with similarly poor prognosis. This suggests a common biology between these tumors and provides a novel classification tool for cancers, adding prognostic and biologic information that is not captured by the mutation status alone. These results may guide therapeutic strategies for this patient segment and may help in population stratification for clinical trials.
Postmenopausal vaginal bleeding in women using hormone replacement therapy
Authors: Burbos Nikolaos , Musonda Patrick , Duncan Timothy J , Crocker Simon G , Nieto Joaquin J , Morris Edward P 
Published: March 2012

Objective To estimate the risk of endometrial cancer in postmenopausal women presenting with vaginal bleeding using estrogen–progestogen hormone replacement therapy (HRT) regimens and to assess if the duration of HRT use has an effect on the risk of diagnosing endometrial cancer. Study design Cross-sectional study of consecutive women presenting with postmenopausal vaginal bleeding at a gynaecological oncology centre in the UK. Main outcome measures Endometrial cancer diagnosis. Results Over a 62-month period, 4847 women were investigated for postmenopausal vaginal bleeding. The majority of women (4097, 84.5%) did not use any HRT preparation at the time of initial referral and 750 (15.5%) women were using combined HRT preparations. A total of 298 (6.1%) women were diagnosed with endometrial carcinoma. Women using HRT preparations were significantly less likely to be diagnosed with endometrial cancer compared with women not using HRT (adjusted odds ratio = 0.229, 95% CI 0.116–0.452; P < 0.0001). The longer duration of HRT use did increase the risk of diagnosing endometrial cancer in women presenting with postmenopausal vaginal bleeding, but this was not statistically significant. Conclusions Postmenopausal women presenting with vaginal bleeding and using combined HRT preparations have significantly lower risk of being diagnosed with endometrial cancer when compared with women not using HRT.
Percutaneous cholecystostomy as an alternative to cholecystectomy in high risk patients with biliary sepsis: a district general hospital experience
Authors: Al–Jundi W , Cannon T , Antakia R , Anoop U , Balamurugan R , Everitt N , Ravi K 
Published: March 2012

INTRODUCTION Cholecystectomy is the standard treatment for patients with acute cholecystitis. However, percutaneous cholecystostomy (PC) is an alternative for patients at high risk for surgery. We present our five-year clinical experience with the aim of evaluating the efficacy of PC in high risk patients. METHODS A retrospective review was performed on 30 consecutive patients who underwent PC at our institution. The indications for cholecystostomy, route of insertion, technical success, clinical improvement, length of hospitalisation, in-hospital or 30-day mortality, complications, subsequent admissions and performance of interval cholecystectomy were recorded. The median follow-up period was 25 months (range: 1–52 months). RESULTS Thirty-two PCs were performed in thirty patients (mean age: 76.1 years; range: 52–90 years). The indications for PC were acute calculous cholecystitis (29/32), acalculous cholecystitis (1/32) and emphysematous cholecystitis (2/32). The route of insertion was transperitoneal for 22/32 PCs (68.8%) and transhepatic for 10/32 (31.2%). The procedure was technically successful in all patients although 2/22 transperitoneal drains (9.1%) were dislodged subsequently. Twenty-seven PCs (84.4%) resulted in clinical improvement within five days. The in-hospital or 30–day mortality rate was 16.7% (5/30). Eleven patients (36.7%) had a subsequent cholecystectomy: 6 were laparoscopic and 5 converted to open procedures at a median interval of 58 days (range: 1–124 days). CONCLUSIONS PCs are straightforward with few complications. Most patients improve clinically and the procedure can therefore be used as a definitive treatment in unfit patients or as a bridge to surgery in those who might subsequently prove fit for a definitive operation.
BOOK REVIEWS
Authors: Houghton Nicholas , Linnap Peeter , Bobick Bryna 
Published: March 2012

ON CRAFTSMANSHIP: TOWARDS A NEW BAUHAUS, CHRISTOPHER FRAYLING (2011) London: Oberon Books, 144 pp., ISBN 978-1-84943-072-2, h/bk, £9.99
PHOTOGRAPHY AFTER CONCEPTUAL ART, DIARMUID COSTELLO AND MARGARET IVERSEN (EDS) (2010) Oxford: Wiley-Blackwell, 200 pp., ISBN: 978-1-4443-3360-2,
p/bk, £19.99, €24.00
UNDERSTANDING STUDENTS WITH AUTISM THROUGH ART, BEVERLY LEVETT GERBER AND JULIA KELLMAN (EDS) (2010) Reston, VA: National Art Education Association, 174 pp., ISBN: 978-1-890160-48-7, p/bk, US$39.00
Book Reviews
Authors: Akcan Esra , Stanton Michael , Alić Dijana , Damluji Mona , King Anthony D. , Elias Chad 
Published: March 2012

STREETS OF MEMORY: LANDSCAPE, TOLERANCE, AND NATIONAL IDENTITY IN ISTANBUL, AMY MILLS, (2010) Athens, GA: University of Georgia Press, xii + 288 pp., ISBN 9780820335735, $64.95 (cloth)/ISBN 9780820335742, $24.95 (paper)
ORIENTING ÍSTANBUL: CULTURA CAPITAL OF
EUROPE?, DENÍZ GÖKTÜRK, LEVENT SOYSAL AND ÍPEK TÜRELÍ (EDS), (2010) London and New York: Routledge, xv + 336 pp., ISBN 9780415580106, $160 (cloth)/ISBN 9780415580113, $62.95 (paper)
LESSONS IN POST-WAR RECONSTRUCTION: CASE STUDIES FROM
LEBANON IN THE AFTERMATH OF THE 2006 WAR, HOWAYDA AL-HARITHY (ED.), (2010) London and New York: Routledge, 218 pp., ISBN 9780415571050, $110 (cloth)
VIOLENCE TAKING PLACE: THE ARCHITECTURE OF THE KOSOVO CONFLICT, ANDREW HERSCHER, (2010) Stanford: Stanford University Press, 198 pp.,
39 b/w illus., ISBN 9780804769358, $21.95 (paper)
BAGHDAD ARTS DECO: ARCHITECTURAL BRICKWORK, 1920–1950, CAECILIA PIERI, (2010) Cairo and New York: American University of Cairo Press, 166 pp., 219 illus., ISBN 9789774163562, $39.95 (cloth)
THE COURTYARD HOUSE: FROM
CULTURAL REFERENCE TO UNIVERSAL RELEVANCE, NASSER O. RABBAT (ED.), (2010) Farnham, Surrey and Burlington, VT: Ashgate Publishing Limited, 260 pp., 120 b/w illus., ISBN 9780754638438, $109 (cloth). Published in association with the Aga Khan Program for Islamic Architecture
MEMORIALS
AND MARTYRS IN MODERN LEBANON, LUCIA VOLK, (2010) Bloomington, IN: Indiana University Press, 272 pp., 23 b/w illus., 1 map, ISBN 9780253355232, $24.95 (paper)
Statistical direct methods revisited. Solving the constraints
Authors: Brosius Jan 
Published: March 2012

Abstract
This paper focuses on statistical methods and formulas that solve the constraints Ȓ

q

2 (x
1, …, x
N) = R

q

2 for all q. To this end we invented several non trivial techniques. We introduce a functional measure that uses the Patterson function and show that this functional measure is equivalent to using a non uniform prior distribution of the x
i given by a product of delta functions δ(Ȓ

q

2(x
1, …, x

N
) – R

q

2. We then use a representation of the delta function for calculating probabilities. In this paper we don‘t aim to give a “final” formula (this we hope to do in a future paper) but we emphasize instead on the method. We also show in this paper that SAD gives almost the same conditional j.p.d. of the phases given the magnitudes of the structure factors. Finally we show that by using plausible prior densities of the x
i the principal part of the probabilities of phases given some neighborhood does not depend anymore on the number of atoms which is a completely new and unexpected result. The Bessel functions will play a dominant role in all our formulas.
Electrocardiogram Screening for Disorders That Cause Sudden Cardiac Death in Asymptomatic Children: A Meta-analysis
Authors: Rodday Angie Mae , Triedman John K. , Alexander Mark E. , Cohen Joshua T. , Ip Stanley , Newburger Jane W. , Parsons Susan K. , Trikalinos Thomas A. , Wong John B. , Leslie Laurel K. 
Published: March 2012

BACKGROUND AND OBJECTIVES:
Pediatric sudden cardiac death (SCD) occurs in an estimated 0.8 to 6.2 per 100 000 children annually. Screening for cardiac disorders causing SCD in asymptomatic children has public appeal because of its apparent potential to avert tragedy; however, performance of the electrocardiogram (ECG) as a screening tool is unknown. We estimated (1) phenotypic (ECG- or echocardiogram [ECHO]-based) prevalence of selected pediatric disorders associated with SCD, and (2) sensitivity, specificity, and predictive value of ECG, alone or with ECHO.

METHODS:
We systematically reviewed literature on hypertrophic cardiomyopathy (HCM), long QT syndrome (LQTS), and Wolff-Parkinson-White syndrome, the 3 most common disorders associated with SCD and detectable by ECG.

RESULTS:
We identified and screened 6954 abstracts, yielding 396 articles, and extracted data from 30. Summary phenotypic prevalences per 100 000 asymptomatic children were 45 (95% confidence interval [CI]: 10–79) for HCM, 7 (95% CI: 0–14) for LQTS, and 136 (95% CI: 55–218) for Wolff-Parkinson-White. The areas under the receiver operating characteristic curves for ECG were 0.91 for detecting HCM and 0.92 for LQTS. The negative predictive value of detecting either HCM or LQTS by using ECG was high; however, the positive predictive value varied by different sensitivity and specificity cut-points and the true prevalence of the conditions.

CONCLUSIONS:
Results provide an evidence base for evaluating pediatric screening for these disorders. ECG, alone or with ECHO, was a sensitive test for mass screening and negative predictive value was high, but positive predictive value and false-positive rates varied.
Investigations of Zipping Mechanism in Relativistic Heavy Ion Interactions With Carbon Onions
Authors: Al-Duhaileb RA , Xie K , Ayres VM , Ronningen RM , Zeller AF , Baumann T , Hirata A 
Published: March 2012

ABSTRACTThe interactions of fully stripped Argon-40 heavy ion beams with 140 MeV/nucleon with a series of increasingly polygonal carbon onions are investigated by high-resolution transmission electron microscopy and thermogravimetric analysis. The experimentally observed graphene layer linking is compared with expected results from the displacement and dislocation migration models. The results suggest that dislocation-driven mechanisms may play a significant role in graphene layer linking induced by heavy ion interactions with carbon onions.
Fabrication and Characterisation of the First Graphene Ring Micro Electrodes (GRIMEs)
Authors: Dickinson J.W. , Andrieux F.P.L. , Boxall C. 
Published: March 2012

ABSTRACTWe report the fabrication and characterisation of the first graphene ring micro electrodes, formed by dip coating fibre optics with subsequently reduced graphite oxide. The behaviour of the so-formed Graphene RIng Micro Electrodes (GRIMEs) is studied using the ferricyanide probe redox system while electrode thicknesses is assessed using established electrochemical methods. A ring electrode of ∼73 nm thickness is produced on 220 μm diameter fibre optics, corresponding to an inner to outer radius ratio of >0.999, so allowing for use of extant analytical descriptions of very thin ring micro electrodes in data analysis. GRIMEs are highly reliable (current response invariant over >3000 scans) with the microring design allowing for efficient use of electrochemically active graphene edge sites. Further, the associated nA scale currents neatly obviate issues relating to the high resistivity of undoped graphene. Thus, the use of graphene in ring micro electrodes improves the reliability of existing micro electrode designs and expands the range of use of graphene-based electrochemical devices.
Technical visit: Banbury flood alleviation scheme
Authors: McMonagle Shane 
Published: March 2012

The British Dam Society was invited to undertake a site visit to the Banbury flood alleviation scheme, organised by committee member and project site supervisor, John Hopkins of Black & Veatch, the scheme’s designers. The visit to the site, located just upstream of the town of Banbury on the River Cherwell, took place on 7 September 2011 with 17 visiting members hosted by the project site team.
Accuracy of Linear Measurements and Visibility of the Mandibular Canal of Cone‐Beam Computed Tomography Images With Different Voxel Sizes: An In Vitro Study
Authors: Waltrick Karen Borges , de Abreu Junior Murillo José Nunes , Corrêa Márcio , Zastrow Michella Dinah , D'Avila Dutra Vinícius 
Published: March 2012

Background: The major use of cone‐beam computed tomography (CBCT) is in implant planning. Although CBCT has been shown to be a reliable tool for measurements, we were unable to find studies comparing the differences between images acquired using different voxel sizes for implant planning. The aims of the present in vitro study are to verify the accuracy of linear measurements and to analyze the visibility of the mandibular canal on CBCT images obtained using different voxel sizes.Methods: Twelve dry human hemimandibles were scanned using voxel sizes of 0.2, 0.3, and 0.4 mm, and 108 transversal CBCT images were generated, on which two examiners performed 648 linear measurements and evaluated the visibility of the mandibular canal.Results: The global mean ± SD error between measurements on images and direct measurements was 0.23 ± 0.20 mm. CBCT measurements underestimated direct measurements in 390 cases (60.2%). All measurement errors found were <1 mm. There was a statistically significant difference (P = 0.0001 and P = 0.0028) between the two examiners only when measuring the width in two posterior sites. There was a statistically significant difference (P = 0.0242) between voxel sizes only for one of the examiners, for a measurement of height. It was possible to visualize the mandibular canal in all of the 108 images evaluated.Conclusions: Transversal CBCT images are adequate for linear measurements in the posterior region of the mandible and provide adequate visualization of the mandibular canal using voxel sizes of 0.2, 0.3, or 0.4 mm. A voxel of 0.3 mm is a good compromise between image quality and low radiation dose.