bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dental injuries among children and adolescents aged 1–15 years attending to public hospital in Temuco, Chile
Authors: Díaz Jaime A. , Bustos Luís , Brandt Andrea C. , Fernández Belén E. 
Published: May 2010

Abstract – A cross‐sectional study was carried out in children and adolescents of both sexes, aged 1–15 years that sought dental emergency attention to the Regional Hospital between 2004 and 2007 in Temuco, Chile. The purpose of this study was to identify the aetiology, types of traumatic dental injuries in primary and permanent dentitions, sex and age distributions, accident location; and time elapsed before emergency treatment in children and adolescents. The sample consisted of 359 patients with 145 primary teeth and 525 permanent teeth affected by dental trauma. The results showed a 2:1 male:female ratio distribution (242/117) with a mean age of 8.4 years. The 7‐ to 12‐year‐old group had the highest frequency of dental injuries (66.6%). Unspecific accidental falls were the main cause of injury to primary and permanent dentition (51.8%), followed by striking teeth against objects (15.6%) and bike accidents (13.9%). In primary dentition the most common diagnosis were subluxation (38.6%) and avulsion (16.6%), whereas in permanent dentition was uncomplicated crown fracture (32.9%). A high proportion of the patients received their first emergency attention 24 h after the accident (32.6%). This study revealed a high frequency (37.9%) in 1–15 aged population that sought emergency attention by dental trauma in the period of time study. A large proportion of children with dental trauma received delayed first emergency care, even 24 h after the accident. Considering the high frequency of traumatic dental injuries in 1–15 aged population and the high percentage of delayed emergency attention is necessary to develop effective educational campaigns in regard to causes, prevention and emergency management of traumatic dental injuries, especially in deprived areas. In conclusion, traumatic dental injury may be considered as a serious dental public health problem especially in children of deprived areas.
A Prospective 1‐Year Clinical and Radiographic Study of Implants Placed after Maxillary Sinus Floor Augmentation with Synthetic Biphasic Calcium Phosphate or Deproteinized Bovine Bone
Authors: Lindgren Christer , Mordenfeld Arne , Hallman Mats 
Published: May 2010

ABSTRACTBackground: The technique of using bone grafts or different biomaterials for augmentation of the maxillary sinus prior to implant placement is well accepted by clinicians. However, clinical documentation of some bone substitutes is still lacking.Purpose: This prospective study was designed to evaluate the success rate of implants placed after maxillary sinus augmentation with a novel synthetic biphasic calcium phosphate (BCP) or deproteinized bovine bone (DBB), the latter acting as control.Material and Methods: Nine edentulous patients and two partially edentulous patients with a mean age of 67 years with a bilateral need for sinus augmentation, <5 mm residual bone in the floor of the sinus and a crestal width ≥4 mm, were included in the study. After bilateral elevation of the Schneiderian membrane, all patients were randomized for augmentation with synthetic BCP in one side and DBB in the contralateral side. After 8 months of graft healing, 62 implants with an SLActive surface were placed. Implant survival, graft resorption, plaque index, bleeding on probing, sulcus bleeding index, probing pocket depth, and implant success rate were evaluated after 1 year of functional loading.Results: After a mean of 118 days, all patients received their fixed prosthetic constructions. One implant was lost in each biomaterial, giving an overall survival rate of 96.8%. Success rates for implants placed in BCP and DBB were 91.7 and 95.7%, respectively. No significant difference in marginal bone loss was found around implants placed in BCP, DBB, or residual bone, respectively. The mean graft resorption was 0.43 mm (BCP) and 0.29 mm (DBB).Conclusion: In this limited study, implant success rate was not dependent on the biomaterial used for maxillary sinus augmentation. Similar results were found after 1 year of functional loading for implants placed after sinus augmentation using BCP or DBB.
Maxillary Sinus Augmentation Using Prehydrated Corticocancellous Porcine Bone: Hystomorphometric Evaluation after 6 Months
Authors: Barone Antonio , Ricci Massimiliano , Covani Ugo , Nannmark Ulf , Azarmehr Iman , Calvo‐Guirado Josè Luis 
Published: May 2010

ABSTRACTBackground: Insufficient alveolar bone height often prevents the placement of standard dental implants in the posterior part of edentulous maxilla. In order to increase adequately the vertical dimension of the reabsorbed alveolar process, a sinus lift procedure is often necessary. The aim of this study was to evaluate histologic results of a prehydrated corticocancellous porcine bone used in maxillary sinus augmentation.Methods: Patients (age 18–70 years) with a residual bone height requiring a maxillary sinus augmentation procedure to place dental implants were eligible for this study. All patients were treated with the same surgical technique consisting of sinus floor augmentation via a lateral approach. The space obtained by elevation of the mucosa wall was grafted with prehydrated and collagenated corticocancellous porcine bone. Biopsies were harvested 6 months after the augmentation procedures.Results: Twenty‐four patients were enrolled. The mean percentage of new formed bone was 43.9 ± 18.6% (range 7.5–100%), whereas the mean percentage of residual graft material was 14.2 ± 13.6% (range 0–41.9%). The new bone/residual graft material ratio in the maxillary sinuses was 3.1. The mean soft tissues percentage was 41.8 ± 22.7% (range 0–92.5%).Conclusion: The present study suggested that porcine bone showed excellent osteoconductive properties and could be used successfully for sinus augmentation. Moreover, the porcine bone showed a high percentage of reabsorption after 6 months; this might be because of the presence of collagen and the porosity of the graft material.
Histomorphometrical Analysis following Augmentation of Infected Extraction Sites Exhibiting Severe Bone Loss and Primarily Closed by Intrasocket Reactive Soft Tissue
Authors: Mardinger Ofer , Vered Marilena , Chaushu Gavriel , Nissan Joseph 
Published: May 2010

ABSTRACTBackground: Intrasocket reactive soft tissue can be used for primary closure during augmentation of infected extraction sites exhibiting severe bone loss prior to implant placement. The present study evaluated the histological characteristics of the initially used intrasocket reactive soft tissue, the overlying soft tissue, and the histomorphometry of the newly formed bone during implant placement.Materials and Methods: Thirty‐six consecutive patients (43 sites) were included in the study. Extraction sites demonstrating extensive bone loss on preoperative periapical and panoramic radiographs served as inclusion criteria. Forty‐three implants were inserted after a healing period of 6 months. Porous bovine xenograft bone mineral was used as a single bone substitute. The intrasocket reactive soft tissue was sutured over the grafting material to seal the coronal portion of the socket. Biopsies of the intrasocket reactive soft tissue at augmentation, healed mucosa, and bone cores at implant placement were retrieved and evaluated.Results: The intrasocket reactive soft tissue demonstrated features compatible with granulation tissue and long junctional epithelium. The mucosal samples at implant placement demonstrated histopathological characteristics of keratinized mucosa with no residual elements of granulation tissue. Histomorphometrically, the mean composition of the bone cores was – vital bone 40 ± 19% (13.7–74.8%); bone substitute 25.7 ± 13% (0.6–51%); connective tissue 34.3 ± 15% (13.8–71.9%).Conclusions: Intrasocket reactive soft tissue used for primary closure following ridge augmentation is composed of granulation tissue and long junctional epithelium. At implant placement, clinical and histological results demonstrate its replacement by keratinized gingiva. The histomorphometrical results reveal considerable bone formation. Fresh extraction sites of hopeless teeth demonstrating chronic infection and severe bone loss may be grafted simultaneously with their removal.
Factors Associated with Failure of Surface‐Modified Implants up to Four Years of Function
Authors: Cosyn Jan , Vandenbulcke Edward , Browaeys Hilde , Van Maele Georges , De Bruyn Hugo 
Published: May 2010

ABSTRACTObjectives: The relative impact of innovative treatment concepts on the failure of surface‐modified implants is not well understood. This retrospective study aimed to explore this using data obtained in a university postgraduate training center.Material and Methods: Patients treated with implants for a variety of indications over a 3‐year period were included. All implants had been at least 1 year in function. Clinical records were evaluated for implant failure and in reference to implant length/diameter/location, time from tooth loss to implant placement, bone condition (native/grafted), surgical protocol (two‐/one‐stage), loading protocol (delayed/early/immediate), type of prosthesis (removable/fixed), surgeon's experience level (resident/trainee) and specialty (periodontist/oral surgeon). The impact of each covariate on failure was tested using the Fisher's exact test. Kaplan‐Meier survival functions were constructed and Mantel‐Cox log–rank tests were used to compare survival functions. To correct for possible interaction, Cox proportional Hazards regression was adopted.Results: Forty‐one of 1,180 (3.5%) implants were lost in 34/461 (7.4%) patients (245 ♀, 216 ♂; mean age 51, range 18–90). Factors showing significant impact on failure on the basis of univariate analyses were implant location (p = .015), surgical protocol (p = .002), loading protocol (p = .002), surgeon's experience level (p = .035) and specialty (p = .001). When controlling for other covariates, only the loading protocol had a significant influence (p = .049) with early loading more prone to failure (p = .014) when compared with delayed loading. Immediate loading and delayed loading showed comparable implant survival (p = .311).Conclusions: Implant therapy may be highly successful in a training center where inexperienced clinicians are strictly monitored and personally guided. Implant specific variables do not affect implant survival but early loading is a risk indicator for implant failure, whereas immediate loading is not.
Single Implant Treatment in Healing versus Healed Sites of the Anterior Maxilla: A Clinical and Radiographic Evaluation
Authors: Eghbali Aryan , De Bruyn Hugo , De Rouck Tim , Cleymaet Roberto , Wyn Iris , Cosyn Jan 
Published: May 2010

ABSTRACTPurpose: The aim was to document the Nobelreplace tapered TiUnite® (Nobel Biocare, Göteborg, Sweden) implant system used by experienced clinicians in daily practice for replacing single maxillary anterior teeth and to compare the clinical and radiographic outcome between implants installed in healing sites (early implant placement) and fully healed sites (conventional implant placement) after on average two and a half years of function.Material and Methods: A cross‐sectional study in patients who had been treated by two periodontists and two prosthodontists in 2006 and 2007 was conducted. Surgical treatment involved standard flap elevation without releasing incisions and restorative procedures included cemented crowns in all patients. Only straightforward single implant treatments in healing sites (6–8 weeks following tooth extraction) and fully‐healed sites (≥6 months following tooth extraction) were considered with both neighboring teeth present and without the need for hard and/or soft tissue grafting. Clinical and radiographic analyses of all implants were performed by a blinded clinician who had not been involved in the treatment.Results: Forty‐nine of the 53 eligible single implants (22 early and 27 conventionally placed implants) in 44/48 patients were available for scrutiny. There was no significant difference in implant survival between early (95%) and conventionally (93%) installed implants (p = 1.000). Mean bone level to the implant‐abutment interface was 1.25 and 1.02 mm for early and conventional implant placement, respectively (p = .220). In spite of fairly low plaque levels (26%), overall peri‐implant bleeding was quite prevalent (36%). Mean peri‐implant probing depth was 3.3 mm. Five restorations had experienced technical complications.Conclusions: Single Nobelreplace tapered TiUnite® implants installed in healing as well as in healed sites of the anterior maxilla are predictable. Both strategies seem equally successful in terms of implant survival, bone remodeling, clinical response, and risk for complications.
An autoinhibitory effect of the homothorax domain of Meis2
Authors: Hyman‐Walsh Cathy , Bjerke Glen A. , Wotton David 
Published: May 2010

Myeloid ecotropic insertion site (Meis)2 is a homeodomain protein containing a conserved homothorax (Hth) domain that is present in all Meis and Prep family proteins and in the Drosophila Hth protein. The Hth domain mediates interaction with Pbx homeodomain proteins, allowing for efficient DNA binding. Here we show that, like Meis1, Meis2 has a strong C‐terminal transcriptional activation domain, which is required for full activation of transcription by homeodomain protein complexes composed of Meis2 and Pbx1. We also show that the activity of the activation domain is inhibited by the Hth domain, and that this autoinhibition can be partially relieved by the interaction of Pbx1 with the Hth domain of Meis2. Targeting of the Hth domain to DNA suggests that it is not a portable trans‐acting repression domain. However, the Hth domain can inhibit a linked activation domain, and this inhibition is not limited to the Meis2 activation domain. Database searching reveals that the Meis3.2 splice variant, which is found in several vertebrate species, disrupts the Hth domain by removing 17 codons from the 5′‐end of exon 6. We show that the equivalent deletion in Meis2 derepresses the C‐terminal activation domain and weakens interaction with Pbx1. This work suggests that the transcriptional activity of all members of the Meis/Prep Hth protein family is subject to autoinhibition by their Hth domains, and that the Meis3.2 splice variant encodes a protein that bypasses this autoinhibitory effect.Structured digital abstract
MINT‐7718353, MINT‐7718083, MINT‐7718172, MINT‐7718256, MINT‐7718300, MINT‐7718330: Meis2d (uniprotkb:O14770‐4) physically interacts (MI:0915) with PBX1 (uniprotkb:P40424) by anti tag coimmunoprecipitation (MI:0007)
MINT‐7718110: Meis2e (uniprotkb:O14770‐5) physically interacts (MI:0915) with PBX1 (uniprotkb:P40424) by anti tag coimmunoprecipitation (MI:0007)
Corpus Cavernosal Smooth Muscle Relaxation Effect of a Novel AMPK Activator, Beta-Lapachone
Authors: Bae Jae Hyun , Kim Jin Wook , Kweon Gi Ryang , Park Myoung Gyu , Jeong Kyeong-Hoon , Kim Je Jong , Moon Du Geon 
Published: May 2010

ABSTRACT

Introduction
Adenosine monophosphate-activated protein kinase (AMPK) activation is suggested to relax smooth muscle by endothelial nitric oxide synthase (eNOS) phosphorylation.

Aim
To assess the mechanism and effect of a novel AMPK activator, beta-lapachone, upon cavernosal smooth muscle relaxation and the therapeutic potential for erectile dysfunction.

Methods
Human umbilical vein endothelial cells (HUVECs) were treated with beta-lapachone. The lysates were blotted with specific antibodies for phosphorylated AMPK (p-AMPK) or phosphorylated eNOS (p-eNOS). The membranes were re-blotted for total AMPK total eNOS, or beta-actin. The eNOS activity was measured by the conversion of L-14C-arginine to L-14C-citrulline in HUVECs lysates. In a separated experiment, cavernosal strips from New Zealand white rabbits were harvested for organ bath study and the relaxation effect of beta-lapachone on phenylephrine-induced contracted strips was evaluated and compared with sodium nitroprusside, zaprinast, metformin, and aminoimidazole carboxamide ribonucleotide (AICAR). Methylene blue and L-NAME were used to assess the inhibition of cyclic guanosine monophosphate/nitric oxide pathway. Zinc-protoporphyrin-IX (ZnPP) was also used to investigate the contribution of mevalonate pathway.

Main Outcome Measures
The expression of p-AMPK, p-eNOS, AMPK and eNOS induced by beta-lapachone in HUVECs study and the percent relaxation of cavernosal tissue in organ bath study.

Results
Beta-lapachone clearly induced AMPK phosphorylation and, as a consequence, eNOS phosphorylation in HUVECs. Beta-lapachone-induced upregulation of eNOS activity was also observed in HUVECs and steadily increased up to 1 hour. In organ bath study, beta-lapachone significantly relaxed the phenylephrine pretreated strips in a dose-dependent manner. This relaxation effect was not totally blocked by methylene blue or L-NAME. After removing endothelium, the relaxation was totally blocked by ZnPP.

Conclusions
A novel AMPK activator, beta-lapachone has a strong relaxation effect on precontracted cavernosal smooth muscle strips in the rabbit. And phosphorylation of AMPK and eNOS strongly related to the action of beta-lapachone. Mevalonate pathway also might be considered as a suggestive mechanism.
Survivorship care after breast cancer: Follow‐up practices of Australian health professionals and attitudes to a survivorship care plan
Authors: BRENNAN Meagan E , BUTOW Phyllis , SPILLANE Andrew J , BOYLE Frances M 
Published: May 2010

AbstractObjective:  The increasing number of breast cancer survivors and the complexity of follow‐up care make the provision of high‐quality survivorship care a challenge. This study explored the follow‐up practices of health professionals and their attitudes to alternative models such as shared care and the use of a survivorship care plan.Methods:  Specialist oncologists (surgeons, medical and radiation oncologists) breast physicians and breast‐care nurses completed an online survey.Results:  A total of 217 practitioners completed the survey, which was estimated to include 42.8% of oncologists treating breast cancer in Australia. One‐third of responding specialists reported spending more than 25% of their clinical time providing follow‐up care. They reported many positive aspects to follow‐up consultations and viewed follow‐up care as an important part of their clinical role but expressed concern about the sustainability of follow‐up care in their practices. The follow‐up intervals and recommendations were in line with national guidelines. The specialists were supportive of sharing follow‐up care with primary‐care physicians, breast physicians and breast‐care nurses. Most professionals felt that a survivorship care plan would improve care and said they would use a proforma.Conclusion:  The oncologists felt that follow‐up care was an important part of their role and they were supportive of the concepts of shared care programs and a survivorship care plan. Input from consumers is required to evaluate the acceptability of these alternative models and to assess ways of implementing these changes to work towards a more comprehensive and sustainable method of delivering survivorship care.
Habitat Use by Sympatric Jaguars and Pumas Across a Gradient of Human Disturbance in Belize
Authors: Foster Rebecca J. , Harmsen Bart J. , Doncaster C. Patrick 
Published: May 2010

ABSTRACTJaguars (Panthera onca) and pumas (Puma concolor) are sympatric across the entire jaguar range, where they coexist in increasingly fragmented landscapes under threat of persecution mainly in response to livestock predation. Pumas are known to inhabit a greater variety of natural habitats than jaguars, but little is known about the influence of anthropogenic factors on the coexistence of these two similar‐sized cats. This study compares habitat use of jaguars and pumas in Belize, Central America, using 1380 jaguar and puma photo captures from 3 yr of camera trapping, comprising 64–74 individual jaguars and an unknown number of pumas. Jaguars and pumas did not differ in their use of a large block of relatively homogenous secondary rain forest. However, pumas were scarce outside this forest block, whereas jaguars were detected throughout the human‐influenced landscape. Reasons for this discrepancy may include differential tolerance to human disturbance, and resource limitation for pumas outside the forest block. Intra‐specific variation in jaguar activity in the form of sex‐dependent habitat use was detected across the landscape. Male jaguars were detected at more locations than female jaguars and more frequently at each location, with a declining difference from a 50‐fold greater detection in the protected forest, through forest buffer, savannah, pastures, to negligible difference in the disturbed forest.
PREFERENCE FOR ONE OF TWO IDENTICAL STIMULI: EXPECTATIONS, EXPLICIT INSTRUCTIONS AND PERSONAL TRAITS
Authors: CHAPMAN KATHRYN W. , LOVELACE EUGENE , CARDELLO ARMAND , LAWLESS HARRY T. 
Published: May 2010

ABSTRACT Most consumers, given two identical food samples, express a preference for one, rather than choosing a no‐preference option. The stability and potential causes of this seemingly irrational preference were examined across three trials under different conditions, specifically, when the first test pair was identical or different, and when participants were explicitly told that the pairs would often be identical. Choice of no preference typically increased from the first to second trial, especially for groups who saw a pair of different samples on the first trial. The explicit instruction that samples might be the same failed to reduce expressing a preference on the initial trial although it had some effect on later trials. Analysis, by individuals, of sequences of preference or no‐preference responses across trials support independence of sequential responses and argue against stable personal traits as a predictor of preference choice. PRACTICAL APPLICATIONSMore research needs to be done to understand the origins and operation of biases in preference tests. When tested under conditions in which the samples differ only slightly, participants tend to avoid the no‐preference option. This is potentially important when interpreting the results of preference tests and assigning practical significance to their outcomes. Also, single trial testing may produce somewhat different results from multi‐trial testing, the latter allowing for examination of effects of variation in recent experience.
Relationships between landforms, soils and vegetation in the River Plate coastal plain, Argentina
Authors: Giménez Jorge E. , Hurtado Martín A. , Kalesnik Fabio , Martínez Omar R. 
Published: May 2010

AbstractThe River Plate coastal plain is a 160‐km‐long, 3–10‐km‐wide strip, located to <5 m a.s.l. on the right bank of the estuary. It is formed by sediments and landforms generated by the littoral transport and marine ingressions and regressions during the Holocene. The coastal plain faces heavy pressures from Buenos Aires Metropolitan Area, with about 13 million inhabitants, industrial, mining and rural activities. Here, we analyse the relations existing between landforms, soils and vegetation. Despite the anthropogenic influence, the natural landscape is more or less preserved in some areas, such as patches of the southernmost gallery forest in the world in natural levees, the xerophytic forests located in well‐drained soils of beach ridges and other units such as Inland and Coastal Mudflats with wetland soils and vegetation, Tidal Flats with contrasting soils and plant communities among others.