bluuebunny/crossref_metadata_2025_split huggingface dataset:
Depression: a modifiable factor in fearful older fallers transitioning to frailty?
Authors: Ní Mhaoláin Aine M. , Fan Chie Wei , Romero‐Ortuno Roman , Cogan Lisa , Cunningham Clodagh , Lawlor Brian , Kenny Rose‐Anne 
Published: December 2011

ObjectiveFear of falling is one of the most common fears among community‐dwelling older people and is as serious a health problem as falls themselves. Understanding fear of falling in fallers transitioning to frailty may help us identify effective strategies to reduce it in this already vulnerable group of older people. Our aim was to evaluate the psychological factors associated with fear of falling in a group of fallers transitioning to frailty when compared with robust or non‐frail fallers.MethodsCross‐sectional design where 301 fallers underwent assessment at the Technology Research for Independent Living Clinic in Dublin (http://www.trilcentre.org/) is seen. Fear of falling was measured using the Modified Falls Efficacy Scale, and frailty was measured using the Biological Syndrome Model. Psychological measures included assessment of anxiety, depression, loneliness, personality factors and cognition.ResultsFrailer fallers had increased fear of falling when compared with robust fallers (p < 0.001). Age, female gender and lower cognitive scores were associated with greater fear of falling in the robust group. For frailer fallers, higher depression score was the only factor associated with fear of falling on multivariate analysis. The odds ratio of having case level depressive disorder (CESD‐8 ≥ 4) if you were a frailer faller was significantly higher than if you were robust (OR = 2.6, CI 1.3–5.2, p = 0.006).ConclusionFallers at a transitional level of frailty may represent a particularly vulnerable group psychologically who would benefit most from interventional stratagies with specific intervention components addressing depressive symptoms. Copyright © 2011 John Wiley & Sons, Ltd.
Post‐traumatic stress disorder symptoms in emotionally distressed individuals referred for a depression prevention intervention: relationship to problem‐solving skills
Authors: Kasckow J. , Brown C. , Morse J. , Begley A. , Bensasi S. , Reynolds C. F. 
Published: December 2011

ObjectivesThis study examined the rates of syndromal and subthreshold post‐traumatic stress disorder (PTSD) and PTSD symptom scores in participants with symptoms of emotional distress, subsyndromal depression, and a history of traumatic exposure. Participants had been referred to a study of an indicated depression prevention intervention using problem‐solving therapy in primary care. We hypothesized that higher severity of PTSD symptom scores would predict poorer problem‐solving skills. In addition, some reports have suggested that there are higher rates of PTSD in minority populations relative to Caucasians; thus we hypothesized that race would also predict problem‐solving skills in these individuals.MethodsWe examined the rates of traumatic exposure, syndromal, and subthreshold PTSD. In those exposed to trauma, we performed a multiple linear regression to examine the effects of PTSD symptoms, depression symptoms, race, age, and gender on social problem‐solving skills.ResultsOf the 244 participants, 64 (26.2%) reported a traumatic event; 6/234 (2.6%) had syndromal PTSD, and 14/234 (6.0%) had subthreshold PTSD. By way of regression analysis, higher PTSD symptom scores predicted poorer problem‐solving skills. In addition, racial status (Caucasian vs. African American) predicted problem‐solving skills; Caucasians exhibited lower levels of problem‐solving skills.ConclusionsIndividuals presenting with subsyndromal depressive symptoms may also have a history of traumatic exposure, subthreshold and syndromal PTSD. Thus, screening these individuals for PTSD symptoms is important and may inform clinical management decisions because problem‐solving skills are lower in those with more severe PTSD symptoms (even after adjusting for race, age, gender, and depressive symptoms). Copyright © 2011 John Wiley & Sons, Ltd.
Real‐time PCR‐based analysis of BRAF V600E mutation in low and intermediate grade lymphomas confirms frequent occurrence in hairy cell leukaemia
Authors: Ewalt Mark , Nandula Subhadra , Phillips Adrienne , Alobeid Bachir , Murty Vundavalli V. , Mansukhani Mahesh M. , Bhagat Govind 
Published: December 2011

AbstractHairy cell leukaemia (HCL) is a rare type of B‐cell non‐Hodgkin lymphoma (B‐NHL), which is not known to be associated with any characteristic recurrent karyotypic abnormality. A recent study that used massively parallel whole exome sequencing identified an activating V600E mutation in BRAF, which appeared specific for HCL. Here, we confirm the specificity of BRAF V600E for HCL among low and intermediate grade B‐NHL and describe a real‐time polymerase chain reaction method for detecting this mutation in cases with low tumour burden. The V600E mutation does not appear to be associated with microsatellite instability, unlike the case in colorectal cancer. Thus, in conjunction with prior data, our results suggest incorporation of BRAF V600E mutation analysis in the diagnostic workup of HCL cases. Additionally, targeting the Ras‐Raf‐Mek‐Erk‐Map kinase pathway should be investigated as a potential therapeutic strategy for patients with this disease. Copyright © 2011 John Wiley & Sons, Ltd.
Differential patterns of opioid use: Defining persistent opioid use in a prescription database
Authors: Svendsen K. , Skurtveit S. , Romundstad P. , Borchgrevink P.C. , Fredheim O.M.S. 
Published: December 2011

AbstractAimThe aim of this study was to develop definitions to identify persons with clinically different patterns of persistent opioid use based on data from prescription databases.MethodsThe study is based on data from the Norwegian Prescription Database using all dispensed opioid prescriptions during 2005–2008. Three definitions of persistent opioid use were developed using the following patient criteria: different levels of dispensed opioid amounts, number of prescriptions and the number of quarters out of the year in which prescriptions were dispensed. The three definitions each have some typical patient characteristics attached to them. The strict definition describes a typical patient using opioids to achieve a continuous serum concentration in the therapeutic range, the intermediate definition represents a typical patient using opioids daily but not around the clock and the wide definition describes a typical patient who uses opioids most of the days. To study whether the definitions accurately represent long‐term use, the patient population was followed for 3 years, and the retention rate within each definition was measured.ResultsThe point prevalence of persistent opioid use in Norway (4,681,134 inhabitants) as defined by the strict, intermediate and wide definitions was 0.16% (n = 7663), 0.50% (n = 23,498) and 1.08% (n = 50,791), respectively, as of 31 December 2007. At the end of the 3‐year study period, the retention within any of the definitions was 83%, 84% and 68% for patients who met the criteria of the strict, intermediate and wide definitions, respectively.ConclusionIn the patient populations identified by the three definitions, a high rate of retention was observed, indicating that the proposed definitions can identify patients with long‐term persistent use of opioids.
TOWARD LIMITING AURAL SCRUPULOSITY WHILE LISTENING
Authors: Zemon Richard 
Published: December 2011

Historically, emphasis has been placed on developing verbal skills toward the goal of improving communication. Success, however, has been limited because this emphasis has been misplaced.The burden of effective communication rests upon the listener and is dependent upon his ability to perceive and interpret not only the verbal but principally the non‐verbal forms of expression. It is virtually impossible to understand and help a person without the ability to understand the total communication pattern. The communicant must also be aware that what has a certain significance to one person has an entirely different meaning to another.
Creativity of university students: What is the impact of field and year of study?
Authors: CHEUNG CHAU‐KIU , RUDOWICZ ELISABETH , YUE XIAODONG , KWAN ANNA S. F. 
Published: December 2011

ABSTRACTThere is a long‐lasting dispute about development of students' creativity in the course of their university education. Both the duration and major field of study may represent the educational effects. To address the issue, the present study collected data (N = 859) from a series of surveys of students in Hong Kong to clarify educational effects by controlling a number of background characteristics and prior scores on creativity. Apart from measuring self‐reported creative traits and creative products, it measured divergent thinking with five tasks to elicit students' creative ideas, which led to scores of fluency, flexibility, novelty, innovativeness, and originality. Results indicate the trend of monotonic decline in creativity with years of study at university and the general superiority of verbal creativity among students of humanities and social sciences, whereas business students had the highest scores on self‐assessed creative traits and products.
Developing and Testing a Turkish Version of Torrance's Tests of Creative Thinking: A Study of Adults
Authors: ASLAN A. ESRA , PUCCIO GERARD J. 
Published: December 2011

AbstractThe present study had two purposes. The first was to translate one of the most popular creativity measures in the West, the Torrance Tests of Creative Thinking, into Turkish and to check the equivalency of the Turkish version against the original English measure. The second, after developing an equivalent form of the TTCT in Turkish, was to compare the creative abilities of an adult Turkish sample, as measured by the Turkish TTCT, against data collected in the United States. All four formats of Torrance's tests were translated into Turkish and evaluated for reliability and equivalency. Students in an English Language Teachers program completed both the original version of the TTCT and the newly translated Turkish version. Analysis of their scores showed a high degree of correspondence between the two language versions. Afterwards, the Turkish TTCT was used to collect data from more than 800 research participants. A cross‐cultural comparison was made to data previously collected in the United States. A number of significant differences emerged between the Turkish and United States samples, such as Verbal Fluency, Verbal Originality, and Abstractness of Titles. These and other results are discussed, such as a comparison between males and females in the Turkish sample.
On Vocational Guidance
Authors: BYRN DELMONT K. 
Published: December 2011

Financial Aid for College Students: Undergraduate, Bulletin No. 18, by Theresa Birch WilkinsIdentifying and Educating Our Gifted Children, Pupil Services Series, No. 1, College of Education, Ohio University, by George E. Hill, Rita J. Lauff, and John E. YoungGroup Procedures in Guidance, by Roy DeVerl Willey and W. Melvin StrongPrinciples and Practices in Guidance, by Emory Stoops and Gunnar L. WahlquistHow to be Accepted by the College of Your Choice, by Benjamin FineAdministration of Guidance Services, by Raymond N. Hatch and Buford Stefflre
Briefing the JOURNALS
Authors: FAILOR CLARENCE W. , WESLEY EMORY JONES 
Published: December 2011

Eli E. Cohen and Lila Rosenblum, “Are Jobs the Answer to Delinquency?” School and SocietyDaniel M. Goodacre III, “Pitfalls in the Use of Psychological Tests,” PersonnelAnn Reid, “Are Special Classes for Slow Learners Worth While?” The Clearing HouseFrank E. Wellman, “Guidance and the Curriculum,” School LifeGarnet Owen, “Does Counseling Mean Coddling?,” The Educational ForumGuy Wagner and Marshall Sanborn, “What Schools Are Doing in Developing Guidance Programs,” EducationArthur S. Adams, “How Shall One Find His Way?” The Educational RecordDelbert C. Miller, “Industry and Community Power, Structure,” American Sociological ReviewWalter Nardelli, “Guidance in the Two‐Year College: A Neglected Area,” Junior College JournalWilbert E. Scheer, “Are We Helping Our Students Face Reality?”, Business Education WorldViona E. Long, “Guidance and the Classroom Teacher,” The Clearing HouseJoe Przychodzin, “Discipline,” The Clearing HouseMarion K. Saunders, “Country Doctors Catch Up,” Harpers MagazineBarron B. Scarborough and John C. Wright, “The Assessment of an Educational Guidance Clinic,” Journal of Counseling PsychologyArthur C. Clarke, “Standing Room Only,” Harpers Magazine
On Vocational Guidance
Authors: BYRN DELMONT K. 
Published: December 2011

Vocational Training Directory of the United States, Nathan M. Cohen.Guidance Aids for a Stronger America, by Harry D. Lovelass.Personality Assessment Procedures, by Robert M. Allen.Boom and Inflation Ahead and What You Can Do About It, by W. M. Kiplinger and staff.Studying the Individual Pupil, by Verna White.The College Entrance Examination Board Report of the President, 1957, by Frank H. Bowles.You: Today and Tomorrow, by Martin R. Katz.Counseling and Learning through Small‐Group Discussion, by Helen I. Driver and ContributorsCommon sense about Giftel Children, by Willard Abraham.Rehabilitation of Deaf‐Blind Persons: A Manual for Professional Workers, a joint project of the Office of Vocational Rehabilitation, U. S. Department of Health, Education, and Welfare and the Industrial Home for the Blind.Modern Hotel Management, by Gerald W. Lattin.Counseling for Personal Adjustment in Schools and Colleges, by Fred McKinney.
On Vocational Guidance
Authors: BYRN DELMONT K. 
Published: December 2011

Therapeutic Psychology: Fundamentals of Counseling and Psychotherapy, by Lawrence M. Brammer and Everett L. ShostromHelping Your Gifted Child, By Ruth StrangGroup Guidance: Principles and Practices, by Jane WartersGraduate Education in the United States, by Bernard BerelsonIt's Your Personality, by William McMahon, Brother Philip Harris, and James CribbinAdmission Requirements of American Medical Colleges Including Canada, 1960–61, compiled by Helen Hofer Gee and E. Shepley NourseGeneral Education for Personal Maturity, by Horace T. Morse and Paul L. Dressel (Editors)Fellowships in the Arts and Sciences 1961–62 (Fourth Edition), by Michael Edmund SchiltzAmerican Universities and Colleges, 1960, edited by Mary IrwinAmerican Junior Colleges, 1960, edited by Edmund J. Gleazer, Jr.A Handbook for College‐Bound Students and Their Counselors, by the Association of College Admissions Counselors. L. H. FritzemeirOperation I.Q.: How to Get Into College and Stay There, by E. E. RobertsThey Come For the Best of Reasons—College Students Today, by W. Max WiseStudent Financial Aid Manual for Colleges and Universities, by Homer D. Babbidge, Jr.The National Defense Counseling and Guidance Training Institutes Program: A Report of the First 50 Institutes, by Leona E. TylerJob Guide for Young Workers, 1960–61 Edition, by the Bureau of Employment Security and the U. S. Employment ServiceWhich College for You, by Edward Hodnett
New Books on Vocational Guidance
Authors: GYSBERS NORMAN C. 
Published: December 2011

The School Counselor, by Richard H. Byrne.The Education of American Teachers, by James B. Conant.Growth and Development of the Young Child (seventh edition), by Marian E. Breckenridge and Margaret N. Murphy.Performance Appraisals, by Alvin F. Zander (ed.).
New Books
Authors: GYSBERS NORMAN C. 
Published: December 2011

Educators Guide to Free Guidance Materials, compiled and edited by Mary H. Saterstrom and Joe A. Steph.1968 College Entrance Guide, by Bernice W. Erinstein. New York: Grosset and DunlapIndividualized Study, by Gerald A. Gladstein.Research for Teachers and Counselors, by E. L. Tolbert.Basic Educational Tests and Measurements, by Quentin Stodola and Kolmer Stordahl.Your Career in Public Relations, by Jody Donohue.On the Job Training and Where to Get It, by Robert A. Liston.Chemical Engineering, by David H. Killeffer.Stroke Rehabilitation: Basic Concepts and Research Trends, edited by William S. Fields and William A. Spencer.Improving Skills in Speech Therapy, by Doris D. Wallace.
Calcineurin serves in the circadian output pathway to regulate the daily rhythm of L‐type voltage‐gated calcium channels in the retina
Authors: Huang Cathy Chia‐Yu , Ko Michael L. , Vernikovskaya Darya I. , Ko Gladys Y.‐P. 
Published: December 2011

AbstractThe L‐type voltage‐gated calcium channels (L‐VGCCs) in avian retinal cone photoreceptors are under circadian control, in which the protein expression of the α1 subunits and the current density are greater at night than during the day. Both Ras‐mitogen‐activated protein kinase (MAPK) and Ras‐phosphatidylionositol 3 kinase‐protein kinase B (PI3K‐AKT) signaling pathways are part of the circadian output that regulate the L‐VGCC rhythm, while cAMP‐dependent signaling is further upstream of Ras to regulate the circadian outputs in photoreceptors. However, there are missing links between cAMP‐dependent signaling and Ras in the circadian output regulation of L‐VGCCs. In this study, we report that calcineurin, a Ca2+/calmodulin‐dependent serine (ser)/threonine (thr) phosphatase, participates in the circadian output pathway to regulate L‐VGCCs through modulating both Ras‐MAPK and Ras‐PI3K‐AKT signaling. The activity of calcineurin, but not its protein expression, was under circadian regulation. Application of a calcineurin inhibitor, FK‐506 or cyclosporine A, reduced the L‐VGCC current density at night with a corresponding decrease in L‐VGCCα1D protein expression, but the circadian rhythm of L‐VGCCα1D mRNA levels were not affected. Inhibition of calcineurin further reduced the phosphorylation of ERK and AKT (at thr 308) and inhibited the activation of Ras, but inhibitors of MAPK or PI3K signaling did not affect the circadian rhythm of calcineurin activity. However, inhibition of adenylate cyclase significantly dampened the circadian rhythm of calcineurin activity. These results suggest that calcineurin is upstream of MAPK and PI3K‐AKT but downstream of cAMP in the circadian regulation of L‐VGCCs. J. Cell. Biochem. 113: 911–922, 2012. © 2011 Wiley Periodicals, Inc.
Identification and functional analysis of novel micro‐rnas in rat dorsal root ganglia after sciatic nerve resection
Authors: Li Shiying , Yu Bin , Wang Shanshan , Gu Yun , Yao Dengbing , Wang Yongjun , Qian Tianmei , Ding Fei , Gu Xiaosong 
Published: December 2011

AbstractPeripheral nerve injures are quite common in clinical practice, and many studies have tried to explore the underlying molecular mechanisms. This study focuses on the identification and functional analysis of novel miRNAs in rat dorsal root ganglia (DRGs) following sciatic nerve resection, which is a classic model for studying peripheral nerve injury and regeneration. By using Solexa sequencing, computational analysis, Q‐PCR verification, and Dicer knockdown assay, 114 novel miRNAs in rats were identified, of which 51 novel miRNAs were first reported in rat DRGs, and 63 novel miRNAs were produced at days 1, 4, 7, and 14 following sciatic nerve resection. We further predicted target genes of these miRNAs and analyzed the biological processes in which they were involved. The identified biological processes were consistent with the time frame of peripheral nerve injury and regeneration, revealing that these miRNAs were genuine miRNAs related to nerve regeneration. Our data provide an important resource for the future study of function and regulation of these miRNAs and contribute to elucidation of tyhe molecular mechanisms responsible for peripheral nerve injury and regeneration. © 2011 Wiley Periodicals, Inc.
The Na+/H+ exchanger‐1 inhibitor cariporide prevents glutamate‐induced necrotic neuronal death by inhibiting mitochondrial Ca2+ overload
Authors: Lee Bo Kyung , Jung Yi‐Sook 
Published: December 2011

AbstractIn the brain, Na+/H+ exchanger‐1 (NHE‐1) activation has a significant impact on ischemic injury, and, in recent studies, NHE‐1 inhibition has been found to protect neurons from ischemic injury. This protective effect has been ascribed to the prevention of apoptosis, but neuronal cell death following ischemia is a consequence of both necrotic and apoptotic cell death. Here, we evaluated the ability of the potent NHE‐1 inhibitor cariporide to prevent necrotic cell death in an in vitro model of excitotoxic neuronal death. Cariporide (100 nM) was found to reduce both glutamate‐induced necrotic and apoptotic neuronal cell death. Ca2+ concentrations were observed to peak twice in cytosol and mitochondria in cultured neuronal cells after glutamate exposure, and cariporide was found to reduce the second Ca2+ concentration increase, but not the first. Furthermore, glutamate‐mediated mitochondrial death pathways involving loss of mitochondrial membrane potential and reactive oxygen species (ROS) accumulation were found to be attenuated by cariporide. In addition, cariporide effectively prevented necrosis following exposure to glutamate and ameliorated the mitochondrial Ca2+ and ROS production increases implicated in necrotic cell death. These results suggest that NHE‐1 participates in the necrotic cell death process and that its inhibition offers a means of preventing both necrosis and apoptosis. © 2011 Wiley Periodicals, Inc.
Expression of inflammatory cytokines following acute spinal cord injury in a rodent model
Authors: Stammers A.T. , Liu J. , Kwon B.K. 
Published: December 2011

AbstractMany therapies that have been developed for acute spinal cord injury (SCI) either influence or are influenced by posttraumatic inflammation. Many such therapies have reportedly produced promising neurologic benefits in animal models of SCI, but demonstrating convincing efficacy in human clinical trials has remained elusive. This discrepancy may be related in part to differences in the inflammatory response to SCI between human patients and the widely studied rodent models. Our objectives were, therefore, to establish the time course of inflammatory cytokine release in the spinal cord of rats after a thoracic contusion, to determine whether the cytokine release was injury dependent, and to correlate these findings with those that we have recently reported for the cerebrospinal fluid (CSF) of human SCI patients. After rodent SCI, GRO (the rat equivalent of IL‐8), IL‐6, IL‐1α, IL‐1β, IL‐13, MCP‐1, MIP1α, RANTES, and TNFα were elevated within the spinal cord, whereas IL‐12p70 was decreased. In human SCI, IL‐6, IL‐8, and MCP‐1 were also elevated within the cerebrospinal fluid but at later times than those observed in the rodent spinal cord. IL‐6, IL‐8, and MCP‐1 were released in an injury‐dependent manner in both the rodent model of SCI and the human condition. In this regard, similar patterns of expression were observed for a number of inflammatory cytokines after SCI in rodent spinal cords and in human CSF. Such proteins may therefore have potential utility as biomarkers and surrogate outcome measures for evaluating biological response to therapeutic interventions. © 2011 Wiley Periodicals, Inc.