bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enabling Regioselective Synthesis of α‐Methyl BODIPYs via H2O2/DMSO‐Promoted Direct Methylation
Authors: Lv Fan , Zhu Shuangshuang , Li Zhong‐Yuan , Wang Wangfei , Wang Hua , Jiao Lijuan , Hao Erhong 
Published: May 2024

AbstractAchieving α‐methylation of BODIPYs remains challenging due to the electron‐deficient property of α‐position of BODIPYs. Herein, a H2O2/DMSO‐promoted radical process was employed, providing an approach for the construction of a series of α‐methyl and α,α‐dimethyl BODIPYs in 57–68% yields. In addition, representative transformations and half‐gram experiments as well as their photophysical properties were studied to examine the potential applications.
Leuco Ethyl Violet as Self‐Activating Prodrug Photocatalyst for In Vivo Amyloid‐Selective Oxygenation
Authors: Furuta Masahiro , Arii Suguru , Umeda Hiroki , Matsukawa Ryota , Shizu Katsuyuki , Kaji Hironori , Kawashima Shigehiro A. , Hori Yukiko , Tomita Taisuke , Sohma Youhei , Mitsunuma Harunobu , Kanai Motomu 
Published: May 2024

AbstractAberrant aggregates of amyloid‐β (Aβ) and tau protein (tau), called amyloid, are related to the etiology of Alzheimer disease (AD). Reducing amyloid levels in AD patients is a potentially effective approach to the treatment of AD. The selective degradation of amyloids via small molecule‐catalyzed photooxygenation in vivo is a leading approach; however, moderate catalyst activity and the side effects of scalp injury are problematic in prior studies using AD model mice. Here, leuco ethyl violet (LEV) is identified as a highly active, amyloid‐selective, and blood‐brain barrier (BBB)‐permeable photooxygenation catalyst that circumvents all of these problems. LEV is a redox‐sensitive, self‐activating prodrug catalyst; self‐oxidation of LEV through a hydrogen atom transfer process under photoirradiation produces catalytically active ethyl violet (EV) in the presence of amyloid. LEV effectively oxygenates human Aβ and tau, suggesting the feasibility for applications in humans. Furthermore, a concept of using a hydrogen atom as a caging group of a reactive catalyst functional in vivo is postulated. The minimal size of the hydrogen caging group is especially useful for catalyst delivery to the brain through BBB.
Endovascular coils extrusion after internal carotid artery occlusion: From management to follow‐up
Authors: Vinciguerra Alessandro , Turri‐Zanoni Mario , Ferrari Marco , Mattavelli Davide , Giorgianni Andrea , Fazio Enrico , Pierro Francesco Di , Rampinelli Vittorio , Gazzini Luca , Verillaud Benjamin , Schreiber Alberto , Calabrese Luca , Bignami Maurizio , Battaglia Paolo , Nicolai Piero , Castelnuovo Paolo , Herman Philippe 
Published: May 2024

Key points
ICA coil extrusion (ICA‐CE) occurs most frequently in the nasopharyngeal/sinonasal site.
Evaluating the ICA coils stability, through an angiography, is of primary importance.
ICA‐CE management needs to be decided based on the patient's symptoms and general status.
Are minimally verbal autistic children's modality and form of communication associated with parent responsivity?
Authors: La Valle Chelsea , Shen Lue , Butler Lindsay K. , Tager‐Flusberg Helen 
Published: May 2024

AbstractPrior work examined how minimally verbal (MV) children with autism used their gestural communication during social interactions. However, interactions are exchanges between social partners. Examining parent–child social interactions is critically important given the influence of parent responsivity on children's communicative development. Specifically, parent responses that are semantically contingent to the child's communication plays an important role in further shaping children's language learning. This study examines whether MV autistic children's (N = 47; 48–95 months; 10 females) modality and form of communication are associated with parent responsivity during an in‐home parent–child interaction (PCI). The PCI was collected using natural language sampling methods and coded for child modality and form of communication and parent responses. Findings from Kruskal‐Wallis H tests revealed that there was no significant difference in parent semantically contingent responses based on child communication modality (spoken language, gesture, gesture‐speech combinations, and AAC) and form of communication (precise vs. imprecise). Findings highlight the importance of examining multiple modalities and forms of communication in MV children with autism to obtain a more comprehensive understanding of their communication abilities; and underscore the inclusion of interactionist models of communication to examine children's input on parent responses in further shaping language learning experiences.
The effectiveness of an executive function program for individuals diagnosed with autism spectrum disorder
Authors: Creem Ashley N. , Leaf Justin B. , Cihon Joseph H. , Gerhardt Peter F. , Lee Matthew , Moon Emma 
Published: May 2024

AbstractAutistics/individuals with autism spectrum disorder (ASD) commonly display deficits in executive functioning. These deficits negatively impact social success and the autistic's/individual with ASD's ability to form meaningful friendships. Yet, there is limited research provided for the effective teaching of executive functioning skills to autistics/individuals with ASD. The current study provides an evidence‐based behavior analytic approach for developing executive functioning skills for autistics/individuals diagnosed with ASD. The study also provides the preliminary steps to creating a curriculum that is easy to implement and uses minimal resources. Finally, the study extends current literature on the Teaching Interaction Procedure (TIP) and evaluates the effectiveness of the TIP for developing executive functioning skills for older children diagnosed with ASD. The executive function program resulted in acquisition of all six targeted executive functioning skills for all the participants. While generalization and maintenance data were slightly variable across participants, all three participants displayed improvement in executive functioning skills following the implementation of the executive function program and a social validity assessment indicated that the participants were satisfied with the skills taught, the treatment, and the outcomes.
Circadian changes of autonomic function in patients with zoster‐associated pain: A heart rate variability analysis
Authors: Mao Peng , Hu Hui‐Min , Li Ran , Zhang Yuan‐Jing , Zhang Yi , Li Yi‐Fan , Fan Bi‐Fa 
Published: May 2024

AbstractObjectiveTo investigate the circadian changes of the autonomic function in patients with zoster‐associated pain (ZAP).MethodsA total of 37 patients with ZAP from April 2022 to October 2022 were enrolled as the observation group, and 37 normal volunteers at the same time were selected as the control group. All participants were required to wear a 24‐h Holter, which was used to compare the heart rate variability (HRV) between the two groups. HRV analysis involved time‐ and frequency‐domain parameters.ResultsThere was no statistically significant difference in general information between two groups. Patients with ZAP had an increased mean heart rate and decreased the standard deviation of normal‐to‐normal (SDNN) R–R interval, the root mean square of the differences (RMSSD) in successive RR interval, low frequency (LF), and high frequency (HF) compared with control groups in all periods (p < .05). The ratio of LF/HF between two groups had no significant difference (p = .245). SDNN had no significant difference between day and night in the control group (p > .05), whereas SDNN of ZAP patients in night period was reduced than that in day period (p < .001). The level of RMSSD during the day was lower than those at night in the control group (p < .05), whereas no significant difference of RMSSD between two periods was observed in patients with ZAP (p > .05).ConclusionThe results of this study indicated that ZAP contributes to the decline of autonomic nervous system (ANS) function, especially parasympathetic components. The patients with ZAP lost parasympathetic advantage and had a worse ANS during the night.
Hemostats in the clinic
Authors: Joshi Maithili , Zhao Zongmin , Mitragotri Samir 
Published: May 2024

AbstractGiven the prevalence of hematological conditions, surgeries, and trauma incidents, hemostats—therapeutics designed to control and arrest bleeding—are an important tool in patient care. The prophylactic and therapeutic use of hemostats markedly enhances survival rates and improves the overall quality of life of patients suffering from these conditions. Since their inception in the 1960s, hemostats have witnessed remarkable progress in terms of the active ingredients utilized, therapeutic outcomes, demonstrated efficacy, and the storage stability. In this review, we provide a comprehensive analysis of commercially available hemostats approved by the FDA, along with newer investigative hemostats currently in active clinical trials. We delve into the modality of active ingredients, route of administration, formulation type, and disease indications of these approved and investigative hemostats. Further, we analyze the trends observed in the hemostat actives for Hemophilia A and B, concluding with insights into the emerging patterns and noteworthy developments to watch for in this dynamic field.
Competing CO and HCOOH Pathways in CO2 Electroreduction
Authors: Huang Aiming , Zhou Tian , Zhang Junjun , Zhang Yifan , Wu Yang , Wang Yong , Luo Wen 
Published: May 2024

AbstractHuman activities have significantly contributed to the increase in global carbon emissions, leading to adverse environmental effects such as global warming. Electrochemical reduction of carbon dioxide (CO2RR) presents a promising approach to mitigate carbon emissions. This process not only stores the low energy density renewable energies into high energy density chemical bonds, but also produces a variety of valuable products, including one‐carbon products like HCOOH and CO, as well as multi‐carbon products like CH3CH2OH and C2H4. Among them, HCOOH and CO can be produced with over 90 % selectivity on various catalysts, indicating their potential for large‐scale applications. However, the precise reaction pathways toward CO and HCOOH remain unclear, and the competition between these pathways often leads to low product selectivity. This review offers a comprehensive examination of the latest research on the selective reduction of CO2 to CO and/or HCOOH, focusing on the development of the reaction mechanisms based on theoretical simulations and experimental investigations, and the application of catalysts designed to fine‐tune CO/HCOOH selectivity. Additionally, this review highlights the challenges and prospects for the further development and understanding of selective catalysts for CO and HCOOH production, aiming to provide valuable insights for future studies in this intriguing and significant research field.
Control over Anion Coordination on Pd(II), Cu(I), and Ag(I) with Regioisomeric Phosphine‐Carboxylate Ligands
Authors: González‐Fernández Elisa , Marinus Nittert , Dhankhar Jyoti , Linden Anthony , Čorić Ilija 
Published: May 2024

AbstractThe coordination of anionic donors is involved at various stages of catalytic cycles in transition‐metal catalysis, but control over the spatial positioning of anions around a metal center is a challenge in coordination chemistry. Here we show that regioisomeric phosphine‐carboxylate ligands provide spatial anion control on palladium(II) centers by favoring either κ2, cis‐κ1, or trans‐κ1 coordination of the carboxylate donor. Additionally, the palladium(II) carboxylates, which contain a methyl donor, upon protonation, deliver metal‐alkyl complexes that feature a coordinated carboxylic acid. Such complexes can be considered as models for the minima that follow the concerted metalation‐deprotonation transition state for C−H activation. The predictability of the coordination modes is further demonstrated on silver(I) and copper(I) centers, for which less common structures of mononuclear and dinuclear complexes can be obtained by using spatial anion control. Our results demonstrate the potential for spatial control over carboxylate anions in coordination chemistry.
How can we further explore the link between self‐criticism and self‐compassion, and disordered eating? Commentary on Paranjothy and Wade's (2024)
Authors: Türk Fidan 
Published: May 2024

AbstractParanjothy and Wade's (2024, A meta‐analysis of disordered eating and its association with self‐criticism and self‐compassion. International Journal of Eating Disorders. https://doi.org/10.1002/eat.24166) systematic review and meta‐analysis of disordered eating and its association with self‐criticism and self‐compassion provides a valuable synthesis of 135 studies. They found that greater levels of self‐criticism and increased disordered eating were associated with lower levels of self‐compassion. These findings highlight the importance of further investigating the complex relationship between these variables to inform effective interventions. This commentary explores what the findings of Paranjothy and Wade (2024) tell us and how we can use their findings to address unresolved problems. I will focus on two primary areas in this commentary: (1) the specificity of self‐criticism and (2) how we could use existing data to enhance the understanding of the etiology and maintenance of disordered eating in relation to self‐criticism and self‐compassion to conduct further research. This commentary argues that there is a need for refinement of the self‐criticism construct (e.g., through qualitative research) to understand how self‐criticism varies across different individuals and cultures, particularly for under‐researched populations. I recommend further research using meta‐analytic structural equation modeling to test different theoretical models to pin down how self‐criticism and self‐compassion function as mechanisms of change in disordered eating.
Shooting area of infrared camera traps affects recorded taxonomic richness and abundance of ground‐dwelling invertebrates
Authors: Gao Meixiang , Sun Jiahuan , Jiang Yige , Zheng Ye , Lu Tingyu , Liu Jinwen 
Published: May 2024

AbstractGround‐dwelling invertebrates are vital for soil biodiversity and function maintenance. Contemporary biodiversity assessment necessitates novel and automatic monitoring methods because of the threat of sharp reductions in soil biodiversity in farmlands worldwide. Using infrared camera traps (ICTs) is an effective method for assessing richness and abundance of ground‐dwelling invertebrates. However, the influence that the shooting area of ICTs has on the diversity of ground‐dwelling invertebrates has not been strongly considered during survey design. In this study, data from six ICTs with two shooting areas (A1, 38.48 cm2; A2, 400 cm2) were used to investigate ground‐dwelling invertebrates in a farm in a city on the Eastern Coast of China from 20: 00 on July 31 to 00:00 on September 29, 2022. Over the course of 59 days and 1420 h, invertebrates within 9 taxa, 2447 individuals, and 112,909 ind./m2 were observed from 222,912 images. Our results show that ICTs with relatively large shooting areas recorded relatively high taxonomic richness and abundance of total ground‐dwelling invertebrates, relatively high abundance of the dominant taxon, and relatively high daily and hourly abundance of most taxa. The shooting areas of ICTs significantly affected the recorded taxonomic richness and abundance of ground‐dwelling invertebrates throughout the experimental period and at fine temporal resolutions. Overall, these results suggest that the shooting areas of ICTs should be considered when designing experiments, and ICTs with relatively large shooting areas are more favorable for monitoring the diversity of ground‐dwelling invertebrates. This study further provides an automatic tool and high‐quality data for biodiversity monitoring and protection in farmlands.
The Environmental Pollutant NO3⋅ Rapidly Damages Alkene Moieties in Lipids Through Electron Transfer
Authors: Chiu Yu‐Chen , Wille Uta , Nathanael Joses G. 
Published: May 2024

AbstractThe presence of alkene moieties in fatty acids of (phospho)lipids and cholesterol derivatives makes them highly susceptible to damage by nitrate radicals (NO3⋅), potentially formed through simultaneous exposure to the environmental air pollutants nitrogen dioxide (NO2⋅) and ozone (O3). Absolute rate coefficients derived from reactions with simplified model systems range from 4 to 8×109 M−1 s−1 in acetonitrile, ranking among the highest determined for NO3⋅ reactions with biomolecules in solution to date. Alkenes featuring an electron‐withdrawing carbonyl substituent also display notable reactivity with k values of (2.5±1.0)×108 M−1 s−1. Calculations suggest that these reactions are initiated by oxidative electron transfer (ET) involving the C=C bond, followed by recombination of the resulting alkene radical cation with nitrate anion (NO3−) to form the nitrate adduct radical as the kinetically controlled product. Conversely, saturated fatty acid derivatives and cholestanol react with NO3⋅ through hydrogen atom transfer (HAT) with rate coefficients of 106–107 M−1 s−1, indicating that biomolecules with a considerable number of non‐ or moderately activated sp3 C−H bonds are also highly susceptible to NO3⋅ attack. These findings underscore the potential health hazards associated with exposure to combined NO2⋅ and O3 gases.
Computational thinking for young indigenous learners in New Zealand
Authors: Fox‐Turnbull Wendy , Wu Shaoqun , Mayo Tiana , Stafford Matthew , Gulati Swati 
Published: May 2024

AbstractComputational thinking, a key component for digital technologies, is defined as an approach to problem‐solving, designing computer systems, and understanding related human behaviours, while drawing on fundamental ideas of computing. It is critical that all young students acquire computational thinking skills during their school age. Technology practice is most successful when embedded within authentic contexts, thus this paper presents a study that facilitated the learning of two concepts of computational thinking: sequencing and orientation within culturally embedded technology practice. The study examines what pedagogies most effectively facilitate computational thinking learning for young Māori learners. In particular, what is the role of using authentic contexts in young Māori learners learning computational thinking? and what teaching strategies engage students effectively? The 4‐week study was undertaken at a local Primary School with a high Māori roll in a low socioeconomic area. The findings suggested that the learning is more effective when the concepts of computation thinking were embedded in the students' cultural and local environment (language, places, stories) through the learning context and the pedagogical strategies.
Comprehensive profiling of endocrine metabolism identifies a novel signature with robust predictive value in ovarian cancer
Authors: Yu Dan , Luo Yan , Guo Rong , Ma Fang , Chang Yunyun , Dang Jianhong 
Published: May 2024

AbstractBackgroundThe cell endocrine pathway is a critical physiological process composed of the endoplasmic reticulum, Golgi apparatus and associated vesicles. Loss of enzymes or proteins can cause dysfunction of endoplasmic reticulum and Golgi apparatus and affect secretion pathways leading to a variety of human diseases, including cancer.MethodsThe single‐cell RNA sequencing and single nucleotide variant principal component analysis data of ovarian cancer were retrieved from The Cancer Genome Atlas and Gene Expression Omnibus (GEO) datasets. Eighty‐four genes from SECRETORY_PATHWAYs were obtained from the gene set enrichment analysis (GSEA) website. Univariate cox regression analyses and ConsensusClusterPlus were used to identify prognostic genes and molecular subtypes, which were validated using the tumor immune dysfunction and exclusion (i.e. TIDE) analysis and gene mutation analysis. A prognosis model was established by randomForestSRC. Abundant infiltrated immune cells and pathway enrichment analyses were carried out, respectively, through ssGSEA, ESTIMATE, MCP‐counter and GSEA. The drug sensitive analysis was performed using pRRophetic package. Immunotherapy datasets and pan‐carcinoma analysis were used to examine the performance of prognostic model.ResultsEighteen prognostic genes from SECRETORY_PATHWAYs were found in both TCGA and GEO datasets. Next, two clusters (C1 and C2) were determined, for which C1 with a poor prognosis had higher immune infiltration. Tumor‐related pathways, such as PATHWAYS_IN_CANCER and B_CELL_RECEPTOR_SIGNALING_PATHWAY, were enriched in C1. Moreover, C2 was suitable for immunotherapy. A four‐gene (DNAJA1, NDRG3, LUZP1 and ZCCHC24) signature was developed and successfully validated. RiskScore of higher levels were significantly associated with worse prognoses. An enhanced immune infiltration, increased pathways score and inappropriate immunotherapy were observed in the high RiskScore group. The high‐ and low‐RiskScore groups had different drug sensitivities. Immunotherapy datasets and pan‐carcinoma analysis indicated that the low RiskScore group may benefit from immunotherapy.ConclusionsBased on the perspective of the secretory signaling pathway, a robust prognostic signature with great performances was determined, which may provide clues for clinical precision treatment of ovarian cancer.
Red blood cell distribution width is a useful biomarker to predict bleeding and thrombosis risks in patients with immune thrombocytopenic purpura
Authors: Nakamura Naokazu , Tsunemine Hiroko , Ikunari Ryo , Tanaka Yasuhiro , Arima Nobuyoshi 
Published: May 2024

AbstractBleeding and thrombosis are common complications during immune thrombocytopenic purpura (ITP) treatment. There is a strong need to predict bleeding and thrombosis risks before ITP treatment to optimize therapy and appropriately manage these complications. We performed a retrospective cohort study of 120 patients with primary ITP to identify a biomarker to predict bleeding and thrombosis. We compared blood test results at diagnosis between patients with and without bleeding or thrombosis episodes. The standard deviation of red blood cell distribution width (RDW‐SD) differed significantly between those with and without bleeding and between those with and without thrombosis, leading us to identify it as a variable representative of risk. RDW‐SD was significantly associated with patient age and with histories of several vascular diseases. Multivariate regression analyses showed that RDW integrated several variables associated with vascular risks. RDW‐SD was significantly associated with difficulty with corticosteroid discontinuation (hazard ratio [HR], 2.22, p = 0.01), incidence of bleeding (HR, 2.75, p< 0.01), incidence of thrombosis (HR, 2.67, p< 0.01) and incidence of infection (HR, 1.78, p = 0.04). The RDW‐SD value at the time of ITP diagnosis is a useful biomarker to predict the risks of bleeding, thrombosis, and other complications.
先天性プロテインC欠損症に伴う上腸間膜静脈血栓症に対し保存的治療をした1例(Superior mesenteric venous thrombosis due to protein C deficiency treated by conservative therapy: A case report)
Authors: 知孝 室谷 , 雅郁 福島 , 靖弘 東出 , 章 是永 , 大輔 是枝 , 真佑 久保 , 大輔 中 
Published: May 2024

要旨今回我々は，プロテインC欠損症に伴う上腸間膜静脈血栓症という希少な1例を経験したので報告する。症例は58歳の男性で，既往症に下肢深部静脈血栓症および肺血栓塞栓症があったためリバロキサバンを服用していた。ところが白内障の手術時に休薬し，その後も5か月間にわたり中止されたままであった。当院受診の2日前より上腹部痛および背部痛を自覚し，その後増悪したため前医を受診した。その結果，腹部造影CT検査にて門脈血栓症を認めたため当院救急搬送となった。腹部は左側を中心に全体的な自発痛と圧痛，また一部には筋性防御も認めた。腹部造影CT検査では，小腸の広範に渡る浮腫性壁肥厚と，上腸間膜静脈に血栓を示唆するcentral lucent signを認めた。緊急手術も考慮したが，術後の短腸症候群が懸念された。またCTにて門脈の完全閉塞はなく，側副血行路も形成されていた。浮腫腸管についても造影効果はあると判断した。これらの理由から，まずはヘパリンによる保存的治療を選択したが，結果的に治療完遂できた。その後の遺伝子解析にて先天性プロテインC欠損症と診断した。我々はこの希少な1例に対し，手術は行わず保存的治療のみで治療できた。先天性の血栓傾向が背景にあり，また腹膜刺激兆候を伴っており腸管壊死の可能性の示唆されるような上腸間膜静脈血栓症であっても，抗凝固薬による保存的加療のみで改善する場合もあることが示唆された。