bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Progress in China’s Anti-Monopoly Investigation into the Pharmaceutical Industry – Comment on the Injectable Polymyxin B Sulfate Case
Authors: Wei De 
Published: June 2024

Abstract
China’s competition authorities imposed a record penalty in the pharmaceutical sector against four pharmaceutical companies for jointly abusing their market dominance and engaging in excessive pricing behavior. This incident caused widespread concern and controversy, and has raised questions about the fairness and transparency of the pharmaceutical industry. From the perspective of antitrust enforcement, the administrative penalty decision has significant value for discussion in several aspects, including the identification of the subjects engaged in joint abuse of market dominance, the delineation of the relevant market, the determination of excessive prices, the imposition of penalties, and subsequent corrective measures. Furthermore, the coordination and cooperation between the competition authorities and the health security authorities in this case also merit discussion. This opinion provides an overview of the grounds of the decision and a detailed analysis in the context of China’s anti-monopoly regulations and guidelines for the pharmaceutical sector.
Negotiating situational abstinence and moderation: a study of regular and heavy-drinking young Nigerians
Authors: Dumbili Emeka W , Uwa-Robinson Kelechi 
Published: June 2024

Abstract
Studies that have examined young people’s drinking behaviour, particularly how they abstain from alcohol or drink lightly and their motivations, have focused on Western contexts. Currently, studies on how and why young Africans abstain from alcohol or drink moderately are lacking. Therefore, there is a need to examine young people’s drinking behaviours/practices on the continent to facilitate health promotion interventions. This study, which uses qualitative data elicited from 53 participants, explores how young Nigerian men and women who consume alcohol and drink heavily enact and negotiate abstinence and moderate drinking and the factors that motivate their choices. Some participants constructed situational abstinence, while others participated in temporary light drinking in their friendship networks, but these attracted some consequences. Peers pressured them, but some deployed the ability to offer ‘valid’ explanations and express self-determination and agency to ward off such pressures and negotiate situational abstinence or moderate drinking. Additionally, the fear of public embarrassment, negative publicity on social media due to intoxication and parental influences motivated some participants’ occasional sobriety. Others relied on previous personal or friends’ negative experiences of drunkenness or the consequences of heavy drinking represented in movies and books to construct occasional light drinking. The findings demonstrated how enacting and rejecting particular forms of masculinity and embodied gendered drinking practices, more generally, in some friendship groups, facilitated situational abstinence and moderation. Policymakers should partner with young people to design interventions that encourage abstinence or moderation and mitigate the current drinking practices in Nigeria, which will enhance health promotion.
Deletion of Trps1 regulatory elements recapitulates postnatal hip joint abnormalities and growth retardation of Trichorhinophalangeal syndrome in mice
Authors: Saeki Naoya , Inui-Yamamoto Chizuko , Ikeda Yuki , Kanai Rinna , Hata Kenji , Itoh Shousaku , Inubushi Toshihiro , Akiyama Shigehisa , Ohba Shinsuke , Abe Makoto 
Published: June 2024

Abstract
Trichorhinophalangeal syndrome (TRPS) is a genetic disorder caused by point mutations or deletions in the gene-encoding transcription factor TRPS1. TRPS patients display a range of skeletal dysplasias, including reduced jaw size, short stature, and a cone-shaped digit epiphysis. Certain TRPS patients experience early onset coxarthrosis that leads to a devastating drop in their daily activities. The etiologies of congenital skeletal abnormalities of TRPS were revealed through the analysis of Trps1 mutant mouse strains. However, early postnatal lethality in Trps1 knockout mice has hampered the study of postnatal TRPS pathology. Here, through epigenomic analysis we identified two previously uncharacterized candidate gene regulatory regions in the first intron of Trps1. We deleted these regions, either individually or simultaneously, and examined their effects on skeletal morphogenesis. Animals that were deleted individually for either region displayed only modest phenotypes. In contrast, the Trps1Δint/Δint mouse strain with simultaneous deletion of both genomic regions exhibit postnatal growth retardation. This strain displayed delayed secondary ossification center formation in the long bones and misshaped hip joint development that resulted in acetabular dysplasia. Reducing one allele of the Trps1 gene in Trps1Δint mice resulted in medial patellar dislocation that has been observed in some patients with TRPS. Our novel Trps1 hypomorphic strain recapitulates many postnatal pathologies observed in human TRPS patients, thus positioning this strain as a useful animal model to study postnatal TRPS pathogenesis. Our observations also suggest that Trps1 gene expression is regulated through several regulatory elements, thus guaranteeing robust expression maintenance in skeletal cells.
An Improved Eigenvalue Estimate for Embedded Minimal Hypersurfaces in the Sphere
Authors: Duncan Jonah A J , Sire Yannick , Spruck Joel 
Published: June 2024

Abstract
Suppose that $\Sigma ^{n}\subset \mathbb{S}^{n+1}$ is a closed embedded minimal hypersurface. We prove that the first non-zero eigenvalue $\lambda _{1}$ of the induced Laplace–Beltrami operator on $\Sigma $ satisfies $\lambda _{1} \geq \frac{n}{2}+ a_{n}(\Lambda ^{6} + b_{n})^{-1}$, where $a_{n}$ and $b_{n}$ are explicit dimensional constants and $\Lambda $ is an upper bound for the length of the second fundamental form of $\Sigma $. This provides the first explicitly computable improvement on Choi and Wang’s lower bound $\lambda _{1} \geq \frac{n}{2}$ without any further assumptions on $\Sigma $.
Increasing aggregate size reduces single-cell organic carbon incorporation by hydrogel-embedded wetland microbes
Authors: Johnston Juliet T , Quoc Bao Nguyen , Abrahamson Britt , Candry Pieter , Ramon Christina , Cash Kevin J , Saccomano Sam C , Samo Ty J , Ye Congwang , Weber Peter K , Winkler Mari-Karoliina Henriikka , Mayali Xavier 
Published: June 2024

Abstract
Microbial degradation of organic carbon in sediments is impacted by the availability of oxygen and substrates for growth. To better understand how particle size and redox zonation impact microbial organic carbon incorporation, techniques that maintain spatial information are necessary to quantify elemental cycling at the microscale. In this study, we produced hydrogel microspheres of various diameters (100, 250, and 500 μm) and inoculated them with an aerobic heterotrophic bacterium isolated from a freshwater wetland (Flavobacterium sp.), and in a second experiment with a microbial community from an urban lacustrine wetland. The hydrogel-embedded microbial populations were incubated with 13C-labeled substrates to quantify organic carbon incorporation into biomass via nanoSIMS. Additionally, luminescent nanosensors enabled spatially explicit measurements of oxygen concentrations inside the microspheres. The experimental data were then incorporated into a reactive-transport model to project long-term steady-state conditions. Smaller (100 μm) particles exhibited the highest microbial cell-specific growth per volume, but also showed higher absolute activity near the surface compared to the larger particles (250 and 500 μm). The experimental results and computational models demonstrate that organic carbon availability was not high enough to allow steep oxygen gradients and as a result, all particle sizes remained well-oxygenated. Our study provides a foundational framework for future studies investigating spatially dependent microbial activity in aggregates using isotopically labeled substrates to quantify growth.
Standardizing imaging findings representation: harnessing Common Data Elements semantics and Fast Healthcare Interoperability Resources structures
Authors: Tejani Ali S , Bialecki Brian , O’Donnell Kevin , Sippel Schmidt Teri , Kohli Marc D , Alkasab Tarik 
Published: June 2024

Abstract

Objectives
Designing a framework representing radiology results in a standards-based data structure using joint Radiological Society of North America/American College of Radiology Common Data Elements (CDEs) as the semantic labels on standard structures. This allows radiologist-created report data to integrate with artificial intelligence-generated results for use throughout downstream systems.

Materials and Methods
We developed a framework modeling radiology findings as Health Level 7 (HL7) Fast Healthcare Interoperability Resources (FHIR) observations using CDE set/element identifiers as standardized semantic labels. This framework deploys CDE identifiers to specify radiology findings and attributes, providing consistent labels for radiology report concepts—diagnoses, recommendations, tabular/quantitative data—with built-in integration with RadLex, SNOMED CT, LOINC, and other ontologies. Observation structures fit within larger HL7 FHIR DiagnosticReport resources, providing output including both nuanced text and structured data.

Results
Labeling radiology findings as discrete data for interchange between systems requires two components: structure and semantics. CDE definitions provide semantic identifiers for findings and their component values. The FHIR observation resource specifies a structure for associating identifiers with radiology findings in the context of reports, with CDE-encoded observations referring to definitions for CDE identifiers in a central repository. The discussion includes an example of encoding pulmonary nodules on a chest CT as CDE-labeled observations, demonstrating the application of this framework to exchange findings throughout the imaging workflow, making imaging data available to downstream clinical systems.

Discussion
CDE-labeled observations establish a lingua franca for encoding, exchanging, and consuming radiology data at the level of individual findings, facilitating use throughout healthcare systems.

Importance
CDE-labeled FHIR observation objects can increase the value of radiology results by facilitating their use throughout patient care.
A first report of the genome size for the freshwater-crab family Trichodactylidae (Decapoda: Brachyura)
Authors: Barioto João G , Moraes Isabela R R , Castilho Antonio L 
Published: June 2024

Abstract
The evaluation of genome size has emerged as a resource for populational, biogeographic, and evolutionary interpretations. Still, little has been recorded on the size of the genomes of decapod crustaceans, mainly freshwater species. Using flow cytometry, we aimed to provide new data on the genome size of the freshwater crabs Trichodactylus fluviatilisLatreille, 1828 and T. petropolitanus (Göldi, 1886) in São Paulo state, southern Brazil. We analyzed 12 individuals with a c-value of 8.0–9.6 picograms. We observed a tendency for freshwater crabs with direct development to have a higher genome-size value than those decapods with indirect development, which links the possible relationship of genome size with the developmental pattern.
Prohibition, Censorship, Denial: Polish Episcopate’s Narrative on (Homo)sexual Acts Between 1945 and 1989
Authors: Laddach Agnieszka 
Published: June 2024

Abstract
One of the most important issues for the Polish Episcopate under communism was moral evaluation of sexual activities. Bishops suggested that, along with other immoral activities, homosexuality resulted from the popularization of Marxism and atheization of customs. This article presents a thematic analysis of the episcopal writings from 1945 to 1989, and their evaluation in light of Michel Foucault’s theory, in order to discuss Polish episcopal power in the context of its narrative on homosexuality. I present the doctrinal and historical context of the analyzed writings in a trichotomy: the Episcopate of Poland, the Apostolic See, and the authorities of the Polish People’s Republic. Moreover, I recognize that components of episcopal discourse suggest a multiplicity of power relations. In the selected period, these forces were the subjects of a game in which the church created strategies and chains of influence, and, as an agent of power, consolidated its position by demanding obedience. This image of the institutional church in Poland was established through a great central mechanism of denial that excluded any possibility of a positive moral evaluation of homosexual and other extramarital acts.
Very low levels of ABCA7 in the cerebrum and Alzheimer’s disease onset between the ages of 60 and 80 independently of APOE
Authors: Garliyev Viktor , Lyssenko Catherine A , Wiener Joel P , Praticò Domenico , Lyssenko Nicholas N 
Published: June 2024

Abstract
This cross-sectional study addressed the ABCA7-Alzheimer’s disease (AD) association. ABCA7 protein levels were quantified in 3 cerebral regions of brain donors with Braak neurofibrillary tangle (NFT) stages 0-V. Ordinal regression models were implemented to estimate the effect of ABCA7 on stopping in an earlier Braak NFT stage versus progressing to the later stages in 2 prespecified age segments. In the final model, high ABCA7 levels in the parietal cortex increased the odds of remaining cognitively healthy (ie, in stages 0/I) versus experiencing AD onset (ie, progressing to stages II-V) in the 61-80 age segment (OR = 2.87, adj 95% CI = 1.41-7.86, adj P = .007, n = 109), after controlling for APOE and other covariates. No ABCA7-AD association was found in the 81-98 age segment (n = 113). Parietal ABCA7 levels in 61-80-year-old with stages II-V were very low, even significantly lower than in 81-98-year-old with stages II-V. ABCA7 levels in the prefrontal cortex and hippocampus predicted AD onset in the 61-80 age segment after adjustment for APOE. ABCA7 levels were also the lowest in 61-80-year-old with frequent neuritic plaques. Thus, very low ABCA7 levels in the cerebrum are associated with AD onset in the 7th-8th decade of life.
The Uchuu-glam BOSS and eBOSS LRG lightcones: exploring clustering and covariance errors
Authors: Ereza Julia , Prada Francisco , Klypin Anatoly , Ishiyama Tomoaki , Smith Alex , Baugh Carlton M , Li Baojiu , Hernández-Aguayo César , Ruedas José 
Published: June 2024

ABSTRACT
This study investigates the clustering and bias of Luminous Red Galaxies (LRG) in the BOSS-LOWZ, -CMASS, -COMB, and eBOSS samples, using two types of simulated lightcones: (i) high-fidelity lightcones from UchuuN-body simulation, employing SHAM technique to assign LRG to (sub)haloes, and (ii) 16 000 covariance lightcones from GLAM-UchuuN-body simulations, including LRG using HOD data from Uchuu. Our results indicate that Uchuu and glam lightcones closely replicate BOSS/eBOSS data, reproducing correlation function and power spectrum across scales from redshifts 0.2 to 1.0, from 2 to $150 \,h^{-1}\,\mathrm{Mpc}$ in configuration space, from 0.005 to $0.7\, h\,\mathrm{Mpc}^{-1}$ in Fourier space, and across different LRG stellar masses. Furthermore, comparing with existing MD-Patchy and EZmock BOSS/eBOSS lightcones based on approximate methods, our GLAM-Uchuu lightcones provide more precise clustering estimates. We identify significant deviations from observations within $20 \,h^{-1}\,\mathrm{Mpc}$ scales in MD-Patchy and EZmock, with our covariance matrices indicating that these methods underestimate errors by between 10 per cent and 60 per cent. Lastly, we explore the impact of cosmology on galaxy clustering. Our findings suggest that, given the current level of uncertainties in BOSS/eBOSS data, distinguishing models with and without massive neutrino effects on large-scale structure (LSS) is challenging. This paper highlights the Uchuu and GLAM-Uchuu simulations’ robustness in verifying the accuracy of Planck cosmological parameters, providing a strong foundation for enhancing lightcone construction in future LSS surveys. We also demonstrate that generating thousands of galaxy lightcones is feasible using N-body simulations with adequate mass and force resolution.
Low-mass planets falling into gaps with cyclonic vortices
Authors: Chametla Raúl O , Sánchez-Salcedo F J , Reyes-Ruiz Mauricio , Carrasco-González Carlos , Chrenko Ondřej 
Published: June 2024

ABSTRACT
We investigate the planetary migration of low-mass planets ($M_p\in [1,15]\, \mathrm{ M}_{\oplus }$, here $\mathrm{ M}_{\oplus }$ is the Earth mass) in a gaseous disc containing a previously formed gap. We perform high-resolution 3D simulations with the fargo3d code. To create the gap in the surface density of the disc, we use a radial viscosity profile with a bump, which is maintained during the entire simulation time. We find that when the gap is sufficiently deep, the spiral waves excited by the planet trigger the Rossby wave instability, forming cyclonic (underdense) vortices at the edges of the gap. When the planet approaches the gap, it interacts with the vortices, which produce a complex flow structure around the planet. Remarkably, we find a widening of the horseshoe region of the planet produced by the vortex at the outer edge of the gap, which depending on the mass of the planet differs by at least a factor of two with respect to the standard horseshoe width. This inevitably leads to an increase in the co-rotation torque on the planet and produces an efficient trap to halt its inward migration. In some cases, the planet becomes locked in co-rotation with the outer vortex. Under this scenario, our results could explain why low-mass planets do not fall towards the central star within the lifetime of the protoplanetary disc. Lastly, the development of these vortices produces an asymmetric temporal evolution of the gap, which could explain the structures observed in some protoplanetary discs.
Cerebrospinal fluid diversion prior to posterior fossa tumor resection in adults: A systematic review
Authors: Vastani Amisha , Baig Mirza Asfand , Ali Fizza , Iqbal Allayna , Sharma Chaitanya , Khizar Khoja Abbas , Vaqas Babar , Lavrador José Pedro , Pollock Jonathan 
Published: June 2024

Abstract

Background
Posterior fossa tumors (PFTs) comprise 15%–20% of adult brain tumors, with the reported frequency of hydrocephalus (HCP) ranging between 3.7% and 58%. Most HCP resolves after resection of PFTs, but studies report persistent or new-onset HCP occurring in between 2% and 7% of cases. Preoperative cerebrospinal fluid (CSF) diversion with a ventriculoperitoneal shunt (VPS), external ventricular drain (EVD), or endoscopic third ventriculostomy (ETV) has been shown to improve outcomes. Evidence regarding the efficacy of these techniques is limited.

Methods
A systematic literature search was performed in line with Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Data points were extracted from individual patient cohort data. A failure rate was determined by the number of patients requiring further postoperative CSF diversion.

Results
In total, 8863 records were identified. Thirteen studies consisting of 17 patient cohorts met our inclusion criteria. Across all individual cohort studies, 2976 patients underwent surgical resection of a PFT in whom the frequency of hydrocephalus at presentation was 22.98% (1.92%–100%), and persistent hydrocephalus following preoperative CSF diversion was 13.63% (0%–18%). Of the 684 hydrocephalic patients, 83.63% underwent CSF diversion in the form of ETV, EVD, or VPS. Between years 1992 and 2020, 1986 and 2021, and 1981and 2013, the pre-resection ETV, EVD, and VPS failure rates were 14.66% (17/116), 16.26% (60/369), and 0% (0/87), respectively.

Conclusions
This systematic review highlights that VPS has a better failure rate profile in minimizing postoperative hydrocephalus in adult patients with PFTs.
Prospective assessment of end-of-life symptoms and quality of life in patients with high-grade glioma
Authors: Walbert Tobias , Schultz Lonni , Mikkelsen Tom , Snyder James Matthew , Phillips Joel , Fortunato John T 
Published: June 2024

Abstract

Background
Glioblastoma and high-grade glioma (HGG) remain non-curable diseases. Symptoms and Quality-of-life (QoL) in the end-of-life (EoL) phase have not been prospectively studied with validated instruments. Therefore, we prospectively assessed symptom progression, symptom management, and hospice utilization in patients with treatment-refractory progressive HGG.

Methods
Patients failing bevacizumab and presenting with a Karnofsky performance score of ≤60, and their caregivers, were eligible. Symptoms, medication, and clinical management were tracked with serial telephone calls every 2 weeks until death utilizing clinical evaluations and the MD Anderson Symptom Inventory Brain Tumor Module (MDASI-BT). The MDASI-BT rates symptoms on a scale from 0 (no symptoms) to 10 (worst).

Results
Fifty-four patient-caregiver dyads were enrolled in the study. Amongst 50 evaluable patients, the most severe symptoms during the last 2 weeks prior to death were drowsiness (9.09 ± 1.44), difficulty with concentration (8.87 ± 2.29), fatigue (8.63 ± 2.03), difficulty speaking (8.44 ± 2.42), weakness (8.27 ± 3.44), and difficulty with understanding (7.71 ± 2.94). All symptoms, except weakness and memory impairment, which were high at baseline, showed statistically significant progression. Seizures were rare and did not progressively worsen near the end of life (1.38 ± 3.02). The decision-making composite score almost doubled during the EoL phase (8.58 ± 1.53).

Conclusions
This is the first prospective study describing symptoms and QoL issues in patients with HGG. Patients suffer from high morbidity in the EoL phase and should be offered early palliative and hospice care to assure proper symptom management and advance care planning.