bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microscopic polyangiitis With Pauci‐Immune Glomerulonephritis Associated With Gastrointestinal Tuberculosis
Authors: Monroy-Portillo Alexis , Vargas-San José Nancy , De León-Perez Werner , Moreno-Alvarado Rodolfo 
Published: February 2025

Introduction: Tuberculosis (TB) is a prevalent disease in Guatemala, present in 20–25 cases per 100 thousand inhabitants. Extrapulmonary TB (EPTB) accounts for only 10%–17% of TB cases. The diagnosis of EPTB is challenging, especially in low‐resource settings, because TB can present with clinical characteristics of rheumatological, oncological, or other infectious diseases. Occasionally, mycobacterial infection stimulates the immune system, inducing the generation of antibodies that may lead to autoimmune diseases secondary to primary TB infection, such as vasculitis. To the best of our knowledge, no data have been reported on the prevalence of vasculitis, although some studies worldwide have determined that small‐vessel vasculitis is the most common. Here, we present a case report of a male patient with EPTB diagnosed with Microscopic polyangiitis (MPA).Methods: A 17‐year‐old boy with no past medical history visited the emergency room with a three‐day history of gastrointestinal bleeding. During hospitalization, acute kidney injury (AKI), disseminated lymphadenopathy, imaging studies, renal biopsy, and immunological tests were performed to confirm the diagnosis.Results: Endoscopy revealed a duodenal lesion containing Mycobacterium TB DNA. Further investigation of AKI led to autoimmune serological tests and kidney biopsy, confirming the diagnosis of antineutrophil cytoplasmic antibodies (ANCA)–positive pauci‐immune GN. The patient was treated with antituberculous agents, steroids, and plasmapheresis. However, he developed alveolar hemorrhage and respiratory failure leading to death.Conclusion: TB is a common disease in low‐income countries, with the pulmonary form being the most common presentation; however, the bacteria can spread to any organ, known as EPTB. It is important to consider that the inflammatory reaction associated with any form of TB can generate other types of noninfectious inflammatory diseases, such as ANCA–positive pauci‐immune GN.
Association of Dietary Intake With the Risk of Atopic Diseases: A Mendelian Randomization Study
Authors: Dai Xixia , Lei Li , Jiang Ling , Hu Yibo , Wu Songjiang , Chen Menglu , Liang Yixuan , Chen Jing , Fu Chuhan , Zeng Qinghai 
Published: February 2025

Introduction: Previous observational studies have shown an association between specific dietary intake and atopic diseases. However, few studies have analyzed the causal effects of dietary factors on risk of atopic diseases. Therefore, we conducted a Mendelian randomization (MR) study to explore these relationships.Methods: In this study, we obtained summary statistics on dietary intake and atopic diseases including atopic dermatitis, allergic asthma, allergic conjunctivitis, and allergic rhinitis from large genome‐wide association studies (GWASs) in European populations. MR analysis was performed using the inverse variance weighted (IVW) method, supplemented with MR Egger, weighted median, maximum likelihood, and weighted model analysis methods.Results: Our study included 34 diet‐related exposure factors. The results indicated that increased intake of filtered coffee could reduce the risk of developing atopic dermatitis. Conversely, higher average monthly intake of other alcoholic drinks was associated with an increased risk of atopic dermatitis. For allergic asthma, higher intake of filtered coffee was identified as a protective factor, while increased average weekly intake of spirits and cherry were considered risk factors. Furthermore, an increase in average weekly intake of beer plus cider was found to potentially lower the risk of allergic conjunctivitis. However, we did not discover any causal association between the risk of allergic rhinitis and the dietary intake factors.Conclusion: This MR study validates the potential causal effects of specific dietary intake on different atopic diseases and provides strong support for the development of individualized prevention strategies and health interventions at the family level.
Accuracy of the Identification and Prognosis Prediction of SOFA‐Based Sepsis‐3 for Septic Patients in the Emergency Department Compared With Sepsis‐2
Authors: Zhang Yi-Jie , Fang Wei , Wang Zhen 
Published: February 2025

Aim: To evaluate the value of the Sequential Organ Failure Assessment (SOFA) score, a Sepsis‐3 criterion, for identification and prognosis prediction among adult patients with sepsis in the emergency department (ED) compared with the Sepsis‐2.Methods: Adult patients with suspected sepsis presenting to the ED were retrospectively identified via Sepsis‐2/Sepsis‐3 criteria. The vital signs, laboratory test results, etc., were collected, and the SOFA/quick SOFA (qSOFA) scores and National Early Warning Score (NEWS) were calculated accordingly. ROC curves were generated to evaluate mortality prediction accuracy.Results: Among the 481 patients included, 288/339 met the Sepsis‐2/Sepsis‐3 criteria, respectively, with moderate between‐protocol consistency (Kappa = 0.507, p < 0.001; concordance = 77.3%); 115 patients (23.9%) died in hospital or within 28 days. SOFA/qSOFA scores and NEWS were significantly greater in the sepsis and death groups (p < 0.001), but there was no between‐group difference for Sepsis‐2/Sepsis‐3. The temperature (T) and respiratory rate (RR) increased in the death group, whereas the systolic blood pressure (SBP) decreased. The usefulness of the SOFA score (AUC = 0.644) for predicting mortality was lower than that of qSOFA score (AUC = 0.716) and NEWS (AUC = 0.718), which could be improved (AUC = 0.701–0.721) by combining with two/three of variables (T, RR, and SBP).Conclusion: Compared with Sepsis‐2, Sepsis‐3 identified more patients with sepsis and was suitable for ED use. The SOFA score had lower mortality prediction accuracy than the qSOFA score and NEWS, which could be significantly improved by combining with two/three variables (T, RR, and SBP).
Why New Nurses of Gen Z in China Are Leaving the Hospitals Within the First Year: A Qualitative Descriptive Study
Authors: Wu Waner , Zhao Xinyu , Liang Xing , Zhai Huimin 
Published: February 2025

Background: Understanding why new nurses quit is vital for hospitals to retain talent. New nurses of Gen Z in China, who have grown up in an era of rapid development, may face unique challenges that lead to their departure, differing from their predecessors. However, research on the turnover causes of new nurses of Gen Z in the context of China’s new era is limited.Aim: The aim of this study was to explore the reasons why new nurses of Gen Z in China leave from hospitals.Design: A descriptive phenomenological study.Methods: From October 2023 to October 2024, semistructured interviews were conducted with 16 new nurses of Gen Z in China. All participants voluntarily resigned from their hospitals in less than a year of employment. The data were analyzed using the Nvivo 11.0 software, employing the Colaizzi method to extract themes.Results: Four themes were identified: unalleviated physical and mental stress (conflict between high expectations and slow adaptation, heavy workload, lack of team support, sense of disparity and role transition, and blow from negative events/nursing errors), development planning and personal pursuit (temporary choice for hospital employment, low professional identity, and “for myself”), the power of social support (influence of parents and the role of peer), and new opportunities.Conclusion: The turnover of China’s new nurses of Gen Z is the result of a combination of multiple factors, which collectively prompts them to leave their hospitals and even the nursing profession. Among these factors, the fundamental reason for their resignation is the lack of fulfillment of their needs.Implications for Nursing Management: It is crucial to create a positive work environment conducive to the growth of new nurses, while paying attention to their needs and formulating retention strategies tailored to the characteristics of Gen Z.
A Cross‐Sectional Analysis of the Incidence of Hydatidiform Mole in Colombia
Authors: González Mariño Mario Arturo 
Published: February 2025

Objective: To describe the incidence of hydatidiform mole in Colombia.Design: Cross‐sectional descriptive study.Setting: Colombia.Population or Sample: The total population at risk of hydatidiform mole (15–49 years old) from 2015 to 2023 was 117.890.729 women.Methods: A search of the national database of the Ministry of Health and Social Protection of Colombia using ICD‐10 for hydatidiform mole and ectopic pregnancy was conducted from 2015 to 2023. Incidences were calculated using data from the National Department of Statistics of Colombia.Main Outcome Measures: The incidence of hydatidiform mole was calculated by ratios compared with the live births, the proportion of pregnancies, and the incidence rate in the at‐risk population.Results: In the reviewed period, 2247 cases of hydatidiform mole were reported. The proportion of unspecified hydatidiform moles during the evaluation period was 78.59% of the reports, the incidence ratio was one hydatidiform mole for every 2486 live births, the proportion was 37.7 × 105 pregnancies and the cumulative incidence was 1.90 × 105 women of 15–49 years. The age range with the highest number of cases was 20–29 years with 1039 cases.Conclusions: The high proportion of unspecified hydatidiform mole far exceeds the diagnoses of complete and partial hydatidiform mole. The descriptive design of the study does not allow us to determine the causes of these results. Future studies with more complex methodological designs are required to explain these findings.
A Comparative Analytical Study of Functional and Esthetic Outcomes of Infraorbital and Subciliary Incisions to Assess the Redundancy of the Infraorbital Approach
Authors: Prince Jefferson , Shetty Premalatha , Ramanathan Arvind , N. Srikant 
Published: February 2025

Objectives: Multiple surgical approaches exist to access the infraorbital region to treat fractures. As with facial approaches, the onus is on good esthetics at the end of the procedure. Access is either through transcutaneous or transconjunctival approaches. In this study, we compared two transcutaneous approaches, the infraorbital and subciliary approaches, to assess functional and esthetic outcomes.Materials and Methods: This was a comparative analytical study of 22 patients over 18 months with zygomaticomaxillary complex (ZMC) fractures, indicated for open reduction and fixation of infraorbital margin. Patients were randomized into subciliary and infraorbital groups, assessed for intraoperative parameters of time, accessibility, and technique sensitivity and evaluated for postoperative esthetic outcomes of edema, scarring, and any complications such as denting ectropion or scleral show at the end of 1 week, 1 month, 3 months, and 6 months.Results: The intraoperative time was three times greater in the subciliary incision group. The accessibility to the fracture site is excellent in the infraorbital approach, although it was also adequate in the subciliary approach. Regarding the esthetic outcomes, denting, scleral show, and ectropion parameters were observed more in the initial postoperative period in the subciliary group and more scar visibility for the same period in the infraorbital group. However, no significant esthetic differences were present between the two approaches at the end of 6 months.Conclusions: The infraorbital approach has low esthetic and functional complications of scleral show and ectropion with relatively good esthetics and ease of performing for infraorbital and orbital floor fractures.
Evaluating the Radiation Sensitivity Index and 12-chemokine gene expression signature for clinical use in a CLIA laboratory
Authors: Berglund Anders E. , Puskas John , Yoder Sean J. , Smith Andrew T. , Marchion Douglas C. , Qin Dahui , Mulé James J. , Torres-Roca Javier F. , Eschrich Steven A. 
Published: February 2025

Abstract
The radiation sensitivity index (RSI) and 12-chemokine gene expression signature (12CK GES) are two gene expression signatures (GES) that were previously developed to predict tumor radiation sensitivity or identify the presence of tertiary lymphoid structures in tumors, respectively. To advance the use of these GES into clinical trial evaluation, their assays must be assessed within the context of the Clinical Laboratory Improvement Amendments (CLIA) process. Using HG-U133Plus 2.0 arrays, we first established CLIA laboratory proficiency. Then the accuracy (limit of detection and macrodissection impact), precision (variability by time and operator), sample type (surgery vs. biopsy), and concordance with reference laboratory were evaluated. RSI and 12CK GES were reproducible (RSI: 0.01 mean difference, 12CK GES 0.17 mean difference) and precise with respect to time and operator. Taken together, the reproducibility analysis of the scores indicated a median RSI difference of 0.06 (6.47% of range) across samples and a median 12CK GES difference of 0.92 (12.29% of range). Experiments indicated that the lower limit of input RNA is 5 ng. Reproducibility with a second CLIA laboratory demonstrated reliability with the median RSI score difference of 0.065 (6% of full range) and 12CK GES difference of 0.93 (12 % of observed range). Overall, under CLIA, RSI and 12CK GES were demonstrated by the Moffitt Cancer Center Advanced Diagnostic Laboratory to be reproducible GES for clinical usage.
Transformative Constitutionalism and the Right to Health in Latin America
Authors: Gutiérrez Silva Rodolfo 
Published: February 2025

The most important objective of transformative constitutionalism is to transform society by fostering democracy, protecting human rights, and seeking to eliminate poverty and reduce inequality. From this perspective, courts always guarantee this transformation through judicial activism. In order to achieve this objective, courts in the Latin American region are expanding their involvement in the health sector in particular. The objective of this article was to analyse the consequences of transformative constitutionalism in the health sector in Brazil, Argentina, Mexico and Colombia. The methodology applied was descriptive. Comparative, qualitative and literature review and 37 semi-structured interviews with judges, academics and public servants were carried out. Despite the progress made, the transformation achieved by the intervention of courts in the protection of the right to health has been only moderate. Transformative constitutionalism is generating internal and external transformations in the health sector of Latin America including direct material, symbolic and indirect transformations; however, there are still concerns about the negative consequences of transformative constitutionalism. Therefore, the promises of transformative constitutionalism remain very far to reach. In conclusion, courts should consider more the structural causes that are affecting health systems and strive more towards equilibrium.
Importance of N2BA Titin in Maintaining Cardiac Homeostasis and Its Role in Dilated Cardiomyopathy
Authors: van der Pijl Robbert , Nusayr Eyad , Strom Joshua , Slater Rebecca , Gohlke Jochen , Hourani Zaynab , Saripalli Chandra , Kolb Justin , Hermanson Kyra , Brynnel Odhin , Smith III John E. , Labeit Siegfried , Methawasin Mei , Granzier Henk 
Published: February 2025

BACKGROUND:
TTN (titin) is the third myofilament type of the cardiac sarcomere and performs important functions that include generating passive tension. Changes in TTN expression are associated with cardiac dysfunction, and TTN is one of the main genes linked to dilated cardiomyopathy (DCM). DCM is frequently associated with changes in the expression of N2BA (compliant cardiac TTN isoform), 1 of the 2 major TTN isoforms found in the heart (the other isoform being the N2B [stiff cardiac TTN isoform]). Whether altered expression of N2BA TTN causes DCM or is a secondary change remains unclear.

METHODS:

Here, we present a mouse model, the Ttn
Δ112-158
model, which specifically shortens the proline, glutamate, valine, lysine region of the N2BA isoform.

RESULTS:

Echocardiography and pressure-volume analysis revealed a DCM phenotype characterized by systolic dysfunction and dilation. RNA sequencing studies showed the absence of proline, glutamate, valine, lysine exons, as expected, but also reduced expressions of exons specific to the N2BA isoform of TTN. Protein studies revealed a reduction in the overall expression level of the N2BA isoform with a concomitant increase in N2B TTN, with preserved TT (total TTN) levels. Passive tension was modestly increased in the Ttn
Δ112-158
model. Western blotting revealed that the N2BA TTN-associated protein MARP1 (muscle ankyrin repeat protein 1) is downregulated during both the pre-DCM and DCM phase. Downregulation of MARP1 coincided with the downregulation of the transcription factor Gata-4 (GATA binding protein 4), an MARP1-regulating and interacting protein, which is associated with DCM development.

CONCLUSIONS:
Thus, N2BA TTN is essential for maintaining cardiac health, and perturbed N2BA-MARP1 signaling contributes to DCM development.
Diagnostic accuracy of high-resolution melting curve analysis for discrimination of oncology-associated EGFR mutations: a systematic review and meta-analysis
Authors: Yu Shu , Cheng Yan , Tang Chen-Cheng , Liu Yue-Ping 
Published: February 2025

Objective To investigate the diagnostic value of high-resolution melting (HRM) analysis for oncology-associated epidermal growth factor receptor ( EGFR) gene mutations. Methods We systematically searched Embase, PubMed, and Web of Science for HRM and EGFR mutation detection studies published through September 2024. True and false positives and negatives were extracted to evaluate the diagnostic accuracy of HRM to detect EGFR mutations. The study was registered at INPLASY (INPLASY202490062). Results Twenty-six articles were obtained from 416 references. The overall diagnostic sensitivity and specificity were high at 0.95 [95% confidence interval (CI), 0.94–0.96] and 0.99 (95% CI, 0.99–0.99), respectively. Other indicators, including the positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio, were 144.91 (95% CI: 69.07–304.04), 0.08 (95% CI: 0.04–0.13), and 2405.21 (95% CI: 1231.87–4696.13), respectively. The Q value of the summary receiver operating characteristic curve was 0.979, and the area under the curve was 0.997. Conclusion As a pre-screening method, the high specificity, sensitivity, low cost, rapid turnaround, and simplicity of HRM make it a good alternative for clinical practice, but positive results must still be obtained for diagnostic confirmation. This study provides a transparent overview of relevant studies in design and conduct.
Embracing the Future by Unlocking the Door to Smart Living: A Systematic Review of Consumers Adoption and Acceptance of Smart Home Devices
Authors: Aggarwal Neha , Singh Seema 
Published: February 2025

Purpose: Smart home devices are a promising technology in the modern era, offering numerous advantages and ease to individuals’ daily lives. Due to its immense potential, the adoption of smart home devices is gaining more popularity. This study provides an in-depth review and evaluation of the present state of consumers’ adoption and acceptance of smart home devices to understand more deeply and identify which factors significantly influence consumers’ decisions. Design/methodology/approach: This study conducts an extensive descriptive analysis of 43 research articles retrieved from the Scopus database using a specified search string. It aims to describe the current level of understanding and synthesize previous research on the adoption of smart home devices employing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol and the Theory, Context, Characteristics, and Methods (TCCM) framework. Findings: The results of the previous literature indicate that publications in this field have significantly increased since 2019, suggesting that academics are becoming more interested in this area of research. The technology acceptance model was the most used theory in previous research. Most of the studies in this domain have used quantitative methods. Survey-based research became the primary approach for collecting data, and partial least squares–structure equation modeling was the most used analytical tool. Originality/value: To the best of the authors’ knowledge, this is the first systematic literature review focusing on the adoption of smart home devices using the TCCM framework and the PRISMA protocol.
The facilitating effect of occupational change on job crafting and innovation performance
Authors: Wu Di , Lin Haitianyu 
Published: February 2025

Background Although occupational change is becoming commonplace for contemporary employees, it remains understudied from the theoretical perspective. With employees bringing along previous job experiences into their new roles, occupational changes potentially create favorable conditions for employees’ job crafting and innovation performance. Objective Based on Career Construction Theory, this study aims to gain a better understanding of the increasingly prevalent phenomenon of occupational change. Specifically, this study explores the potential facilitating effect of occupational change on job crafting and subsequently on employee innovation performance. Method A questionnaire survey administered to 413 employees was conducted to examine the proposed hypotheses. Analysis of Covariance (ANCOVA) and a mediation analysis using bootstrapped sampling were employed in the data analyses. Results The results confirmed the hypothesis that occupational change experience is positively associated with employee job crafting. Moreover, job crafting was found to play a full mediating role in the relationship between occupational change experience and employee innovation performance. Conclusion This study serves as an exploratory attempt to better understand the new and under-researched topic of occupational change. By focusing on the new experience and capabilities that occupational changers can bring to their new jobs, this study proposes that occupational changes could potentially facilitate job crafting which further enhances innovation performance. In this vein, this study provides new theoretical insights and meaningful managerial suggestions on the topic of occupational change.