bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conflicting Expectations of Interpreters’ Roles in the Interaction between Guardians and Unaccompanied Minors
Authors: Remue Lotte , Verhaeghe Floor , Derluyn Ilse , Maryns Katrijn 
Published: April 2024

Abstract
Public service interpreters assume a key role in rendering accessible social services to newcomer clients. They could even be considered inherent to social work settings that are multilingual in nature, such as the interactional context of unaccompanied minors and their legal guardians. However, despite the intrinsic linguistic diversity and the unique position of interpreters in this setting, guardian–minor encounters remain unexplored in research. The current study therefore aims to provide insight into the multilingual needs and challenges in these encounters, focussing particularly on the roles interpreters play in this setting and how they are perceived to affect the interaction. To this end, the study draws on twelve semi-structured interviews with guardians of unaccompanied minors, collected as part of a research project examining the impact of multilingual strategies on the communication and relationship between guardians and minors in Belgium. Through thematic analysis, the study explores guardians’ insecurities, revealing confusion about the professional status of interpreters, concerns about interpretation quality and conflicting expectations of what interpreters should (not) do. The study provides recommendations with a view to improving both the confidence of guardians and the efficiency of guardian–minor interactions, and highlights the relevance of the findings for various other social work settings.
Atrocity’s Glass Booth
Authors: Jain Neha 
Published: April 2024

Abstract
This paper foregrounds the defendant as a central actor in trials for mass atrocity. It excavates the practices and scripts of these trials to argue that they are driven by an impulse to construct flat perpetrator portraits. Perpetrators who enter into atrocity’s glass booth are transformed into defendants who are hostis humani generis. Perpetrators who escape this mythification are still viewed as perpetual perpetrators, the moment of their participation in atrocity radiating outwards to demarcate the juridical bookends of their lives. These lives, moreover, are seen as consisting of active choices representing uncompromised agency. The paper suggests that these portraits are tied to international criminal law’s attempt to justify itself as a normative project that claims to act in the name of humanity. It concludes that international criminal law’s aims would be better realized by viewing defendants as equal and engaged members of the community of humanity.
Synergistic effects of plant genotype and soil microbiome on growth in Lotus japonicus
Authors: Bamba Masaru , Akyol Turgut Yigit , Azuma Yusuke , Quilbe Johan , Andersen Stig Uggerhøj , Sato Shusei 
Published: April 2024

Abstract
The biological interactions between plants and their root microbiomes are essential for plant growth, and even though plant genotype (G), soil microbiome (M), and growth conditions (environment; E) are the core factors shaping root microbiome, their relationships remain unclear. In this study, we investigated the effects of G, M, and E and their interactions on the Lotus root microbiome and plant growth using an in vitro cross-inoculation approach, which reconstructed the interactions between nine Lotus accessions and four soil microbiomes under two different environmental conditions. Results suggested that a large proportion of the root microbiome composition is determined by M and E, while G-related (G, G × M, and G × E) effects were significant but small. In contrast, the interaction between G and M had a more pronounced effect on plant shoot growth than M alone. Our findings also indicated that most microbiome variations controlled by M have little effect on plant phenotypes, whereas G × M interactions have more significant effects. Plant genotype-dependent interactions with soil microbes warrant more attention to optimize crop yield and resilience.
Strategic Ambiguity, Strategic Clarity, and Dual Clarity
Authors: Wang Austin Horng-En , Wu Charles K S , Yeh Yao-Yuan , Chen Fang-Yu 
Published: April 2024

Abstract
The United States has successfully prevented the military conflict between China and Taiwan since the 1980s through the Strategic Ambiguity (SA) strategy, which discourages both sides from deviating from the status quo by not committing to defend or not to defend Taiwan. The recent US–China tensions and the rising nationalism in China and Taiwan drew critics to SA and suggested it be replaced with the strategic clarity strategy. We argue that the choice of Dual Clarity (DC)—the United States promises to defend only if Taiwan does not unilaterally declare de jure independence—is widely ignored. We examine the psychological mechanisms behind the three strategies through a pre-registered, within-subject survey experiment in Taiwan (n = 910). The result shows that DC can keep the status quo similar to SA—respondents lowered their support of independence in both DC and SA conditions. The results hold through robustness checks and formalized by a game-theoretical model.
Multicenter validation study of a treatment selection MAP for pancreatic neuroendocrine tumors
Authors: Ikeda Masafumi , Hijioka Susumu , Ito Tetsuhide , Matsumoto Shigemi , Honma Yoshitaka , Ueno Makoto , Okano Naohiro , Aoki Taku , Furuse Junji 
Published: April 2024

Abstract

Background
Somatostatin analogs, molecular-targeted agents and cytotoxic anticancer agents are available as therapeutic agents for the systemic treatment of pancreatic neuroendocrine tumors, and we have developed a first-line treatment selection MAP to enable selection of the optimal treatment strategy for pancreatic neuroendocrine tumors. The purpose of this study was to validate the usefulness of the treatment selection MAP.

Methods
Patients who had received systemic therapy for a pancreatic neuroendocrine tumor between January 2017 and December 2020 were compared according to whether they had been treated as recommended by the MAP (matched patients) or not (unmatched patients) to determine whether better outcomes were achieved by the matched patients. The primary endpoint was progression-free survival of the matched group and unmatched groups in the somatostatin analog, molecular-targeted agent and cytotoxic anticancer agents areas of the MAP.

Results
There were 41 (55%) MAP-matched patients in all areas among the 74 patients registered at seven hospitals. The MAP-matched rates were 100, 77 and 38% in the somatostatin analog area, molecular-targeted agent area and cytotoxic anticancer agents area, respectively. All of the unmatched patients had been selected for less intensive treatment. The median progression-free survival in the matched group and unmatched group in the molecular-targeted agent area of the MAP were 46.6 and 15.4 months, respectively, and a multivariate analysis identified MAP-matched (hazard ratio 0.18 [95% confidence interval: 0.04–0.87], P = 0.032) as the only significant independent favorable predictive factor.

Conclusion
The usefulness of the MAP for treatment selection was validated in the molecular-targeted agent area of the MAP.
Dynamic engraving characteristics of nylon belt under different charge conditions
Authors: Yang Ming , Yu Yong-gang 
Published: April 2024

Abstract
In the present study, a 105 mm short tube gun system was designed to conduct the firing experiments under low charge conditions, which could precisely obtain the projectile displacement data and projectile base pressure data during the engraving process. Besides, a 3-dimensional dynamic engraving FEM-SPH model was established by coupling the internal ballistic process to much authentic investigate the engraving characteristics of the projectile, which were verified and compared through the experiment. On this premise, the influence mechanism and engraving features of the nylon belt were numerically calculated under higher charge conditions. The comparison between the experimental recovery belt and the numerical calculation results shows that the damage to the front of the nylon belt is axial compression wear, while the damage to the back of the nylon belt is circumferential shear wear. The direction of force exerted by the slope chamber and the projectile body on the belt was inconsistent, causing a bulge in the middle of the nylon belt. The more rapid the average boosting rate, the stronger the instantaneous impact on the nylon belt, the larger the stress and the strain damage on the nylon belt, the higher the pressure at the end of the engraving process and the greater the maximum engraving resistance. When the average boosting rate increased from 2.7 MPa⋅ms−1 to 33.0 MPa⋅ms−1, the engraving time was shortened by 73.9%, while the maximum engraving resistance increased by 78.2%.
pAGN: the one-stop solution for AGN disc modelling
Authors: Gangardt Daria , Trani Alessandro Alberto , Bonnerot Clément , Gerosa Davide 
Published: April 2024

ABSTRACT
Models of accretion discs surrounding active galactic nuclei (AGNs) find vast applications in high-energy astrophysics. The broad strategy is to parametrize some of the key disc properties such as gas density and temperature as a function of the radial coordinate from a given set of assumptions on the underlying physics. Two of the most popular approaches in this context were presented by Sirko & Goodman and Thompson et al. We present a critical reanalysis of these widely used models, detailing their assumptions and clarifying some steps in their derivation that were previously left unsaid. Our findings are implemented in the pAGN module for the Python programming language, which is the first public implementation of these accretion-disc models. We further apply pAGN to the evolution of stellar-mass black holes embedded in AGN discs, addressing the potential occurrence of migration traps.
Scalable inference with autoregressive neural ratio estimation
Authors: Anau Montel Noemi , Alvey James , Weniger Christoph 
Published: April 2024

ABSTRACT
In recent years, there has been a remarkable development of simulation-based inference (SBI) algorithms, and they have now been applied across a wide range of astrophysical and cosmological analyses. There are a number of key advantages to these methods, centred around the ability to perform scalable statistical inference without an explicit likelihood. In this work, we propose two technical building blocks to a specific sequential SBI algorithm, truncated marginal neural ratio estimation (TMNRE). In particular, first, we develop autoregressive ratio estimation with the aim to robustly estimate correlated high-dimensional posteriors. Secondly, we propose a slice-based nested sampling algorithm to efficiently draw both posterior samples and constrained prior samples from ratio estimators, the latter being instrumental for sequential inference. To validate our implementation, we carry out inference tasks on three concrete examples: a toy model of a multidimensional Gaussian, the analysis of a stellar stream mock observation, and finally, a proof-of-concept application to substructure searches in strong gravitational lensing. In addition, we publicly release the code for both the autoregressive ratio estimator and the slice sampler.
Model-independent test of the running Hubble constant from the Type Ia supernovae and the Hubble parameter data
Authors: Xu Bing , Xu Jiancheng , Zhang Kaituo , Fu Xiangyun , Huang Qihong 
Published: April 2024

ABSTRACT
In this study, we model-independently investigate the behaviour of running Hubble constant, characterized by the fit function $H_{\rm 0}(z)=\tilde{H_{\rm {0}}}/(1+z)^{\alpha }$, where α represents the evolutionary parameter and ${\tilde{H_{\rm {0}}}}$ corresponds to the current value of Hubble constant. Our analysis utilizes the expansion rate E(z) data points measured from the Pantheon + Multi-Cycle Treasury compilation of Type Ia supernova data, the measurements of H0 obtained by Riess et al., and the Hubble parameter H(z) data obtained from the differential ages of passive galaxies [known as cosmic chronometer (CC) method] and from the baryon acoustic oscillation (BAO) in the radial direction of galaxy clustering. To resolve the redshift mismatch problem between the E(z) and H(z) data sets, we adopt the Hubble parameter data obtained via CC or BAO along with the measurements of H0 obtained by Riess et al. to reconstruct the H(z) function using the Gaussian process. Our constraint yields α values of 0.125 ± 0.063 or 0.095 ± 0.052 when combining six pairs of the E(z) data and the reconstructed H(z) points via CC or BAO. These findings reveal that the Hubble constant may evolve with redshift, exhibiting a slowly decreasing trend, with α coefficients consistent with zero only at 2.0σ or 1.8σ. Therefore, the running Hubble constant might offer a promising resolution to the Hubble tension, and its reliability should be further tested through high-precision measurement at higher redshifts, such as the upcoming gamma-ray bursts and quasars.
The youngest of hot jupiters in action: episodic accretion outbursts in Gaia20eae
Authors: Nayakshin Sergei , Cruz Sáenz de Miera Fernando , Kóspál Ágnes 
Published: April 2024

ABSTRACT
Recent imaging observations with ALMA and other telescopes found widespread signatures of planet presence in protoplanetary discs at tens of au separations from their host stars. Here we point out that the presence of very massive planets at 0.1 au sized orbits can be deduced for protostars accreting gas at very high rates, when their discs display powerful Thermal Instability (TI) bursts. Earlier work showed that a massive planet modifies the nature of this instability, with outbursts triggered at the outer edge of the deep gap opened by the planet. We present simulations of this effect, finding two types of TI outbursts: downstream and upstream of the planet, which may or may not be causally connected. We apply our model to the outburst in Gaia20eae. We find that the agreement between the data and our disc TI model is improved if there is a planet of six Jupiter masses orbiting the star at 0.062 au separation. Gaia20eae thus becomes the second episodically erupting star, after FU Ori, where the presence of a massive planet is strongly suspected. Future observations of similar systems will constrain the mode and the frequency of planet formation in such an early epoch.
Short 2′-O-methyl/LNA oligomers as highly-selective inhibitors of miRNA production in vitro and in vivo
Authors: Koralewska Natalia , Corradi Eloina , Milewski Marek C , Masante Linda , Szczepanska Agnieszka , Kierzek Ryszard , Figlerowicz Marek , Baudet Marie-Laure , Kurzynska-Kokorniak Anna 
Published: April 2024

Abstract
MicroRNAs (miRNAs) that share identical or near-identical sequences constitute miRNA families and are predicted to act redundantly. Yet recent evidence suggests that members of the same miRNA family with high sequence similarity might have different roles and that this functional divergence might be rooted in their precursors' sequence. Current knock-down strategies such as antisense oligonucleotides (ASOs) or miRNA sponges cannot distinguish between identical or near identical miRNAs originating from different precursors to allow exploring unique functions of these miRNAs. We here develop a novel strategy based on short 2′-OMe/LNA-modified oligonucleotides to selectively target specific precursor molecules and ablate the production of individual members of miRNA families in vitro and in vivo. Leveraging the highly conserved Xenopus miR-181a family as proof-of-concept, we demonstrate that 2′-OMe/LNA-ASOs targeting the apical region of pre-miRNAs achieve precursor-selective inhibition of mature miRNA-5p production. Furthermore, we extend the applicability of our approach to the human miR-16 family, illustrating its universality in targeting precursors generating identical miRNAs. Overall, our strategy enables efficient manipulation of miRNA expression, offering a powerful tool to dissect the functions of identical or highly similar miRNAs derived from different precursors within miRNA families.
CARM1 hypermethylates the NuRD chromatin remodeling complex to promote cell cycle gene expression and breast cancer development
Authors: Chen Xue , Huang Ming-feng , Fan Da-meng , He Yao-hui , Zhang Wen-juan , Ding Jian-cheng , Peng Bing-ling , Pan Xu , Liu Ya , Du Jun , Li Ying , Liu Zhi-ying , Xie Bing-lan , Kuang Zhi-jian , Yi Jia , Liu Wen 
Published: April 2024

Abstract
Protein arginine methyltransferase CARM1 has been shown to methylate a large number of non-histone proteins, and play important roles in gene transcriptional activation, cell cycle progress, and tumorigenesis. However, the critical substrates through which CARM1 exerts its functions remain to be fully characterized. Here, we reported that CARM1 directly interacts with the GATAD2A/2B subunit in the nucleosome remodeling and deacetylase (NuRD) complex, expanding the activities of NuRD to include protein arginine methylation. CARM1 and NuRD bind and activate a large cohort of genes with implications in cell cycle control to facilitate the G1 to S phase transition. This gene activation process requires CARM1 to hypermethylate GATAD2A/2B at a cluster of arginines, which is critical for the recruitment of the NuRD complex. The clinical significance of this gene activation mechanism is underscored by the high expression of CARM1 and NuRD in breast cancers, and the fact that knockdown CARM1 and NuRD inhibits cancer cell growth in vitro and tumorigenesis in vivo. Targeting CARM1-mediated GATAD2A/2B methylation with CARM1 specific inhibitors potently inhibit breast cancer cell growth in vitro and tumorigenesis in vivo. These findings reveal a gene activation program that requires arginine methylation established by CARM1 on a key chromatin remodeler, and targeting such methylation might represent a promising therapeutic avenue in the clinic.
Disease burden and healthcare utilization in pediatric low-grade glioma: A United States retrospective study of linked claims and electronic health records
Authors: Zelt Susan , Cooney Tabitha , Yu Sandie , Daral Shailaja , Krebs Blake , Markan Riddhi , Manley Peter , Kieran Mark , Govinda Raju Sandya 
Published: April 2024

Abstract

Background
Despite high long-term survival rates, pediatric low-grade gliomas (pLGGs) are linked with significant tumor- and treatment-associated morbidities that may persist throughout life. The aims of this descriptive cross-sectional pilot study were to characterize health conditions among a cohort of patients with pLGG and explore the feasibility of quantifying disease burden and healthcare resource utilization (HRU).

Methods
Optum® Market Clarity Data were used to identify patients aged ≤18 years with an ICD-10 code for brain neoplasm, ≥1 physician notes, and with evidence of pLGG recorded between January 1, 2017 and June 30, 2018. Outcomes including health characteristics, HRU, medications, and procedures were assessed at 6-month intervals over 36 months.

Results
One hundred and fifty-four patients were identified with pLGG and over half experienced headache/migraine, respiratory infection, pain, or behavioral issues during the 36-month study period. The most common comorbidities were ocular/visual (including blindness), mental health disorders, seizures, and behavioral/cognition disorders. Most symptoms and comorbidities persisted or increased during the study period, indicating long-term health deficits. HRU, including speciality care visits, filled prescriptions, and administered medications, was common; 74% of patients had prescriptions for anti-infectives, 56% antiemetics, and 52% required pain or fever relief. Sixty-five percent of patients underwent treatment to control their pLGG, the most common being brain surgery. Little decline was observed in medication use during the study period.

Conclusions
Patients with pLGG have complex healthcare needs requiring high HRU, often over a long time. Patients need to be optimally managed to minimize disease- and treatment-related burden and HRU.
Walking a middle path: the liberal international order, global economic governance, and India’s G20 presidency
Authors: Bery Suman 
Published: April 2024

Abstract
The article assesses India’s views on the evolving liberal international economic order through an analysis of India’s 2023 G20 presidency. Despite the G20’s commitment to strong, sustainable, balanced, and inclusive growth (SSBIG), economic and social performance and prospects for the least developed economies have steadily deteriorated over the past decade, further compounded by the Covid-19 pandemic, geopolitical polarization and the return of war in Europe. India used the G20 as a platform to craft a distinctive, heterodox view on contemporary growth and development challenges to support its own economic rise and to provide political and intellectual leadership of the Global South. It also brokered the induction of the African Union as a full member of the G20. Through effective economic diplomacy, India’s presidency delivered a consensus Leaders’ document that articulates a heterodox growth and development model for itself and other emerging and developing countries.
Zooplankton seasonal vertical migration in an optimality-based plankton ecosystem model
Authors: Grossowicz Michal , Pahlow Markus 
Published: April 2024

Abstract
Several species from various zooplankton taxa perform seasonal vertical migrations (SVM) of typically several hundred meters between the surface layer and overwintering depths, particularly in high-latitude regions. We use OPtimality-based PLAnkton (OPPLA) ecosystem model) to simulate SVM behavior in zooplankton in the Labrador Sea. Zooplankton in OPPLA is a generic functional group without life cycle, which facilitates analyzing SVM evolutionary stability and interactions between SVM and the plankton ecosystem. A sensitivity analysis of SVM-related parameters reveals that SVM can amplify the seasonal variations of phytoplankton and zooplankton and enhance the reduction of summer surface nutrient concentrations. SVM is often explained as a strategy to reduce exposure to visual predators during winter. We find that species doing SVM can persist and even dominate the summer-time zooplankton community, even in the presence of Stayers, which have the same traits as the migrators, but do not perform SVM. The advantage of SVM depends strongly on the timing of the seasonal migrations, particularly the day of ascent. The presence of higher (visual) predators tends to suppress the Stayers in our simulations, whereas the SVM strategy can persist in the presence of non-migrating species even without higher predators.
Key topics for making decisions on decorporation terapies
Authors: Reis Arlene , Sampaio Camilla , Sousa Wanderson , Aguiar Laís , Bertelli Luiz 
Published: April 2024

Abstract
Decorporation therapies increase the excretion of the incorporated material and therefore may reduce the probability of the occurrence of stochastic effects and may avoid deterministic effects in persons internally contaminated with radionuclides. The decision to initiate decorporation therapy should consider the effects of treatment in relation to the benefit provided. The literature presents threshold values above which treatment is recommended. The objective of this work is to collect and summarize recommendations on decorporation therapy. Ten key topics are presented for consideration by a multidisciplinary team when assessing the risk–benefit balance for performing decorporation therapy.