bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential pheromone profile as a contributor to premating isolation between two sympatric sibling fruit fly species
Authors: Castro-Vargas Cynthia , Oakeshott John Graham , Yeap Heng Lin , Lacey Michael J , Lee Siu Fai , Park Soo Jean , Taylor Phillip Warren , Pandey Gunjan 
Published: June 2024

Abstract
Bactrocera tryoni (Froggatt) and Bactrocera neohumeralis (Hardy) are sibling fruit fly species that are sympatric over much of their ranges. Premating isolation of these close relatives is thought to be maintained in part by allochrony—mating activity in B. tryoni peaks at dusk, whereas in B. neohumeralis, it peaks earlier in the day. To ascertain whether differences in pheromone composition may also contribute to premating isolation between them, this study used solid-phase microextraction and gas chromatography-mass spectrometry to characterize the rectal gland volatiles of a recently collected and a more domesticated strain of each species. These glands are typical production sites and reservoirs of pheromones in bactrocerans. A total of 120 peaks were detected and 50 were identified. Differences were found in the composition of the rectal gland emissions between the sexes, species, and recently collected versus domesticated strains of each species. The compositional variation included several presence/absence and many quantitative differences. Species and strain differences in males included several relatively small alcohols, esters, and aliphatic amides. Species and strain differences in females also included some of the amides but additionally involved many fatty acid esters and 3 spiroacetals. While the strain differences indicate there is also heritable variation in rectal gland emissions within each species, the species differences imply that compositional differences in pheromones emitted from rectal glands could contribute to the premating isolation between B. tryoni and B. neohumeralis. The changes during domestication could also have significant implications for the efficacy of Sterile Insect Technique control programs.
Recent advances in the multifaceted functions of Cys2/His2-type zinc finger proteins in plant growth, development, and stress responses
Authors: Lu Yuchun , Wang Kaili , Ngea Guillaume Legrand Ngolong , Godana Esa Abiso , Ackah Michael , Dhanasekaran Solairaj , Zhang Yu , Su Yingying , Yang Qiya , Zhang Hongyin 
Published: June 2024

Abstract
Recent research has highlighted the importance of Cys2/His2-type zinc finger proteins (C2H2-ZFPs) in plant growth and in responses to various stressors, and the complex structures of C2H2-ZFP networks and the molecular mechanisms underlying their responses to stress have received considerable attention. Here, we review the structural characteristics and classification of C2H2-ZFPs, and consider recent research advances in their functions. We systematically introduce the roles of these proteins across diverse aspects of plant biology, encompassing growth and development, and responses to biotic and abiotic stresses, and in doing so hope to lay the foundations for further functional studies of C2H2-ZFPs in the future.
How Video Game Music Plays Us
Authors: Ayers William R. 
Published: June 2024

Abstract
In an analysis of 3D action-adventure video games, William R. Ayers highlights the modular nature of their music. These musical modules require player input to be activated, and this is a part of the interactivity that games afford. But, as Ayers demonstrates, such musical interactivity and modularity is not unique to this genre of video games; these games continue a tradition of musical practice that can be traced back to the early years of silent film, where accompanists in the theater were provided not with complete scores but with cue categories or topics aligned with the film’s scenes. These plot or mood topics formed the basis for the accompanist’s selection of musical pieces; a practice of creating narrative pathways through films, and a practice that, as Ayers shows, is still extant in the use of interactive musical modules to support gameplay in 3D action-adventure games.
Ambiguity and Vagueness in Video Game Sound
Authors: Grimshaw-Aagaard Mark 
Published: June 2024

Abstract
Mark Grimshaw-Aagaard makes the case that focus should be placed on the study of ambiguity and vagueness in relation to video game sound design and analysis. In this, he proffers the opinion that ambiguity and vagueness should be utilized as video game sound design tools not least as an antidote to the dead-end of deathly realism. Grimshaw-Aagaard begins his chapter with a brief survey of ambiguity in language and vagueness in the natural sciences, before he demonstrates how an understanding of our perception’s ability to easily resolve and deal with these everyday facts of life can enhance video game sound design.
Playground Disco
Authors: Fritsch Melanie 
Published: June 2024

Abstract
Melanie Fritsch explains in her chapter that, despite media attention during the COVID-19 pandemic helping to highlight the release of video games depicting dance club culture—games often used by those unable to physically partake in clubbing—such depictions and the virtual experiences they bring with them are nothing new. Equally, discos and clubs have been used to market new games—a practice that can be traced back to at least the 1970s. Fritsch explores this overlooked relationship, showing the manifold ways in which game developers have explored and exploited club culture and social practices and suggesting that this naturally occurs because both forms provide experiential opportunities for staging “ludic possibility spaces.”
Of Guitar Heroes and Rocksmiths
Authors: Duby Marc 
Published: June 2024

Abstract
Marc Duby uses J. J. Gibson’s theories of ecological psychology and his concept of affordances to explore the links between electric guitar-playing and music video games such as Guitar Hero and Rocksmith. The chapter uses this framework to probe aspects of guitar heroism, networks of technology used to create signature sounds, and questions of authenticity and play in the chosen music video games. Throughout, Duby questions the valorization of the music played on actual instruments over the music produced by players of guitar games, suggesting instead that, while such games have in some cases inspired players to turn to real electric guitars, guitar games hold the promise of an “as yet unexplored musicality.”
Introduction
Authors: Gibbons William , Grimshaw-Aagaard Mark 
Published: June 2024

Abstract
Using the metaphor of video game “hub worlds,” in the Introduction the editors outline the overall purpose, structure, and contents of the handbook. Just as hubs provide a convenient central location for players to gather, exchange ideas, or level up, this volume presents a starting point for the journey into video game music and sound. The chapters, organized by topic into nine major sections, reflect a wide range of disciplines and approaches to the study of game audio drawn from musicology, music theory, sound studies, music cognition, and related fields. Following an overview of each section of the book, brief summaries of each chapter are provided.
Towards Reliable Detection of Introgression in the Presence of Among-Species Rate Variation
Authors: Koppetsch Thore , Malinsky Milan , Matschiner Michael 
Published: June 2024

Abstract
The role of interspecific hybridization has recently seen increasing attention, especially in the context of diversification dynamics. Genomic research has now made it abundantly clear that both hybridization and introgression—the exchange of genetic material through hybridization and backcrossing—are far more common than previously thought. Besides cases of ongoing or recent genetic exchange between taxa, an increasing number of studies report “ancient introgression”— referring to results of hybridization that took place in the distant past. However, it is not clear whether commonly used methods for the detection of introgression are applicable to such old systems, given that most of these methods were originally developed for analyses at the level of populations and recently diverged species, affected by recent or ongoing genetic exchange. In particular, the assumption of constant evolutionary rates, which is implicit in many commonly used approaches, is more likely to be violated as evolutionary divergence increases. To test the limitations of introgression detection methods when being applied to old systems, we simulated thousands of genomic datasets under a wide range of settings, with varying degrees of among-species rate variation and introgression. Using these simulated datasets, we showed that some commonly applied statistical methods, including the D-statistic and certain tests based on sets of local phylogenetic trees, can produce false-positive signals of introgression between divergent taxa that have different rates of evolution. These misleading signals are caused by the presence of homoplasies occurring at different rates in different lineages. To distinguish between the patterns caused by rate variation and genuine introgression, we developed a new test that is based on the expected clustering of introgressed sites along the genome and implemented this test in the program Dsuite.
Operative Versus Nonoperative Treatment of Displaced Proximal Humerus Fractures in Adolescents: Results of a Prospective Multicenter Study
Authors: Hosseinzadeh Pooya , Torres-Izquierdo Beltran , Tippabhatla Abhishek , Denning Jaime , Vidyadhar Upasani , Sanders Julia , Goldstein Rachel , Baldwin Keith 
Published: June 2024

Background:
Proximal humerus fractures (PHFx) constitute around 2% of all pediatric fractures. Although younger children with displaced fractures often undergo nonoperative treatments, optimal treatment for adolescents is not well defined. The study aimed to assess the outcomes of operative versus nonoperative treatment of displaced proximal humerus fractures in adolescents via a prospective multicenter study.

Methods:
This prospective study assessed adolescents aged 10 to 16 years with displaced PHFx from 2018 to 2022 at 6 level 1 trauma centers. Displacement criteria for inclusion were >50% shaft diameter or angulation >30 degrees on AP/lateral shoulder X-rays. Operative versus nonoperative treatment was decided by the treating physician. Radiographic and clinical data were collected at 6 weeks, 3, and 6 months. Patient-reported outcomes (PROs) included: Patient Reported Outcome Measures (PROMIS), Shoulder Pain and Disability Index (SPADI), and QuickDASH questionnaires. Patients were further grouped into a severe displacement cohort, defined as angulation >40° or displacement >75%. Clinical and radiographic data were compared between the 2 treatment cohorts.

Results:
Out of 78 enrolled patients, 36 (46%) underwent operative treatment. Patients treated operatively were significantly older (13.5 vs. 12.2 y, P<0.001) and exhibited greater mean angulation on AP shoulder view at presentation (31.1° vs. 23.5°, P<0.05). All PROs improved over time. At 6 weeks, operative patients demonstrated superior PROMIS upper extremity scores based on the minimally clinically important difference (MCID) (46.4 vs. 34.3, P=0.027); however, this distinction disappeared by 3 months. In a subanalysis of 35 patients with severe displacement, 21 (60.1%) underwent surgical intervention. No metrics showed significant differences between treatment modalities, with all PROs achieving population norm values by 3 months. Range of motion showed no difference between operative and nonoperative treatments, irrespective of fracture displacement.

Conclusion:
We found no differences in PROs and ROM between operative and nonoperative treatments of PHFx. If not contraindicated, nonoperative treatment may reduce healthcare costs and risks associated with surgery and should be considered for displaced adolescent proximal humerus fractures, irrespective of fracture displacement.

Level of Evidence:
II
Behavioral Assessment With the Coma Recovery Scale—Revised Is Safe and Feasible in Critically Ill Patients With Disorders of Consciousness
Authors: Woodward Matthew R. , Wells Chris L. , Arnold Shannon , Dorman Farra , Ahmed Zaka , Morris Nicholas A. , Ciryam Prajwal , Podell Jamie E. , Chang Wan-Tsu W. , Zimmerman W. Denney , Motta Melissa , Butt Bilal , Pergakis Melissa B. , Labib Mohamed , Wang Ting I. , Edlow Brian L. , Badjatia Neeraj , Braun Robynne , Parikh Gunjan Y. 
Published: June 2024

OBJECTIVES:
Accurate classification of disorders of consciousness (DoC) is key in developing rehabilitation plans after brain injury. The Coma Recovery Scale—Revised (CRS-R) is a sensitive measure of consciousness validated in the rehabilitation phase of care. We tested the feasibility, safety, and impact of CRS-R-guided rehabilitation in the ICU for patients with DoC after acute hemorrhagic stroke.

DESIGN:
Retrospective cohort study.

SETTING:
This single-center study was conducted in the neurocritical care unit at the University of Maryland Medical Center.

PATIENTS:
We analyzed records from consecutive patients with subarachnoid hemorrhage (SAH) or intracerebral hemorrhage (ICH), who underwent serial CRS-R assessments during ICU admission from April 1, 2018, to December 31, 2021, where CRS-R less than 8 is vegetative state/unresponsive wakefulness syndrome (VS/UWS); CRS-R greater than or equal to 8 is a minimally conscious state (MCS).

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
Outcomes included adverse events during CRS-R evaluations and associations between CRS-R and discharge disposition, therapy-based function, and mobility. We examined the utility of CRS-R compared with other therapist clinical assessment tools in predicting discharge disposition. Seventy-six patients (22 SAH, 54 ICH, median age = 59, 50% female) underwent 276 CRS-R sessions without adverse events. Discharge to acute rehabilitation occurred in 4.4% versus 41.9% of patients with a final CRS-R less than 8 and CRS-R greater than or equal to 8, respectively (odds ratio [OR] 13.4; 95% CI, 2.7–66.1; p < 0.001). Patients with MCS on final CRS-R completed more therapy sessions during hospitalization and had improved mobility and functional performance. Compared with other therapy assessment tools, the CRS-R had the best performance in predicting discharge disposition (area under the curve: 0.83; 95% CI, 0.72–0.94; p < 0.0001).

CONCLUSIONS:
Early neurorehabilitation guided by CRS-R appears to be feasible and safe in the ICU following hemorrhagic stroke complicated by DoC and may enhance access to inpatient rehabilitation, with the potential for lasting benefit on recovery. Further research is needed to assess generalizability and understand the impact on long-term outcomes.
Development of a Human Trafficking Flowsheet for Clinical Forensic Examiners
Authors: Sonsiadek Jennifer S. , DeVore Heather K. , Toliver Christine , Yingling Cara 
Published: June 2024

ABSTRACT
When trafficked patients are identified in the healthcare setting, clinical forensic examiners, including sexual assault nurse examiners (SANEs), may be consulted to provide medical care and to collect forensic evidence. However, using a standard sexual assault protocol and documentation form may not completely identify or address the unique needs of these patients. Our SANE program sought to improve the healthcare approach to trafficked patients by developing a trafficking-specific documentation flowsheet. The goal of this quality improvement project was to guide a clinical forensic examiner through a comprehensive examination while addressing specific patient needs and optimizing trauma-informed service delivery. We gathered several local multidisciplinary human trafficking specialists together to provide expert recommendations and feedback during the creation process. Both paper and electronic forms of the flowsheet were designed. SANEs completed the flowsheet on 22 patient encounters and filled out a utilization review survey describing their experience. Feedback data collected through the utilization review process guided further modifications to the flowsheet, which were then implemented into clinical practice guidelines. We found that engaging multidisciplinary specialists and community partners both enhanced the effectiveness of the flowsheet and supported the learning needs of our SANEs. We recommend that clinical forensic programs that wish to develop a similar flowsheet collaborate with local professional agencies to meet the unique needs of the populations within their catchment area and use examiner feedback to maximize the usefulness of the flowsheet.
Comparison of efficacy and safety between robotic-assisted versus laparoscopic surgery for locally advanced mid-low rectal cancer following neoadjuvant chemoradiotherapy: a systematic review and meta-analysis
Authors: Zhu Xin-Mao , Bai Xiao , Wang Hai-Qi , Dai Dong-Qiu 
Published: June 2024

Background:
To some extent, the robotic technique does offer certain benefits in rectal cancer surgery than laparoscopic one, while remains a topic of ongoing debate for rectal cancer patients who have undergone neoadjuvant chemoradiotherapy (NCRT).

Methods:
Potential studies published until January 2024 were obtained from Web of Science, Cochrane Library, Embase, and PubMed. Dichotomous and continuous variables were expressed as odds ratios (ORs) or weighted mean differences (WMDs) with 95% CIs, respectively. A random effects model was used if the I
2 statistic >50%; otherwise, a fixed effects model was used.

Results:
Eleven studies involving 1079 patients were analysed. The robotic-assisted group had an 0.4 cm shorter distance from the anal verge (95% CI: −0.680 to −0.114, P=0.006) and 1.94 times higher complete total mesorectal excision (TME) rate (OR=1.936, 95% CI: 1.061–3.532, P=0.031). However, the operation time in the robotic-assisted group was 54 min longer (95% CI: 20.489–87.037, P=0.002) than the laparoscopic group. In addition, the robotic-assisted group had a lower open conversion rate (OR=0.324, 95% CI: 0.129–0.816, P=0.017) and a shorter length of hospital stay (WMD=−1.127, 95% CI: −2.071 to −0.184, P=0.019).

Conclusion:
Robot-assisted surgery offered several advantages over laparoscopic surgery for locally advanced mid-low rectal cancer following NCRT in terms of resection of lower tumours with improved TME completeness, lower open conversion rate, and shorter hospital stay, despite the longer operative time.
Genetic background of pulmonary (vascular) diseases – how much is written in the codes?
Authors: Eichstaedt Christina A. , Haas Simon O. , Shaukat Memoona , Grünig Ekkehard 
Published: June 2024

Purpose of review
To provide a comprehensive overview of the underlying genetic defects of pulmonary (vascular) diseases and novel treatment avenues.

Recent findings
Pulmonary arterial hypertension (PAH) is the prime example of a pulmonary vascular disease, which can be caused by genetic mutations in some patients. Germline mutations in the BMPR2 gene and further genes lead to vessel remodelling, increase of pulmonary vascular resistance and onset of heritable PAH. The PAH genes with the highest evidence and strategies for genetic testing and counselling have been assessed and evaluated in 2023 by international expert consortia. Moreover, first treatment options have just arisen targeting the molecular basis of PAH.

Summary
Apart from PAH, this review touches on the underlying genetic causes of further lung diseases including alpha 1 antitrypsin deficiency, cystic fibrosis, familial pulmonary fibrosis and lymphangioleiomyomatosis. We point out the main disease genes, the underlying pathomechanisms and novel therapies trying not only to relieve symptoms but to treat the molecular causes of the diseases.
Interictal Electroencephalography and Functional Magnetic Resonance Imaging Reveals Involvement of Mesial Anterior Frontal Structures in Patients With Hyperkinetic Semiology Type I
Authors: Kokkinos Vasileios 
Published: June 2024

Purpose:
This work investigates the presence of common anatomic regions associated with interictal activity in patients with hyperkinetic seizures type I by means of concurrent electroencephalography and functional magnetic resonance imaging.

Methods:
Six patients with hyperkinetic seizures type I were evaluated with video-EEG and electroencephalography and functional magnetic resonance imaging in the context of their presurgical evaluation. Statistical Parametric Mapping was used to perform a correlation study between the occurrence of interictal spikes on EEG and suprathreshold blood oxygen level–dependent changes in the whole-brain volume.

Results:
In all patients, Statistical Parametric Mapping revealed suprathreshold blood oxygen level–dependent clusters in the mesial anterior frontal areas, including the rostral mesial superior frontal gyrus and the anterior cingulate, associated with the patients' typical interictal activity.

Conclusions:
The electroencephalography and functional magnetic resonance imaging findings contribute to our understanding of hyperkinetic seizures type I semiology generation and can inform stereo-EEG targeting for surgical planning in refractory cases.
Goal-oriented temperature management in severely traumatized children in the emergency department: an evidence-based practice project
Authors: Wang Wenchao , Zhang Yanhong , Ling Fang , Hu Shenjie , Gu Ying 
Published: June 2024

ABSTRACTIntroduction and objectives:Hypothermia commonly occurs in trauma patients. Evidence-based practices for hypothermia prevention are not strictly followed by all medical staff in the emergency department. This study aimed to assess compliance with evidence-based practices regarding goal-oriented temperature management for severely traumatized children in a Chinese hospital.Methods:This project used the JBI Evidence Implementation Framework to translate evidence into practice. The Integrated-Promoting Action on Research Implementation in Health Services (i-PARIHS) framework was used to identify barriers to compliance with best practices. A goal-oriented temperature management strategy for trauma patients was developed based on the identified barriers, along with a simulation training module, and the supply of warming materials. Field observation, review of medical records, and interviews with medical staff and patients were used to assess baseline and follow-up audit compliance with best practices.Results:Twelve criteria were audited in the baseline and follow-up audits, with 11 and 37 trauma patients, respectively. In the follow-up audit, compliance with all criteria increased, with a reduction in shivering and cold discomfort scores. Except for two patients who died, hypothermia did not occur in any of the patients.Conclusions:The JBI Evidence Implementation Framework was used to successfully improve compliance with best practices. Future audits should be conducted to sustain the evidence-based behavior of all medical staff.Spanish abstract:http://links.lww.com/IJEBH/A234
Experimental neutrino physics in a nuclear landscape
Authors: Parno D. S. , Poon A. W. P. , Singh V. 
Published: June 2024

There are profound connections between neutrino physics and nuclear experiments. Exceptionally precise measurements of single and double beta-decay spectra illuminate the scale and nature of neutrino mass and may finally answer the question of whether neutrinos are their own anti-matter counterparts. Neutrino–nucleus scattering underpins oscillation experiments and probes nuclear structure, neutrinos offer a rare vantage point into collapsing stars and nuclear fission reactors and techniques pioneered in neutrino nuclear physics experiments are advancing quantum sensing technologies. In this article, we review current and planned efforts at the intersection of neutrino and nuclear experiments.
This article is part of the theme issue ‘The liminal position of Nuclear Physics: from hadrons to neutron stars’.