bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Orthogonal α‐meso‐Linked bisBODIPY Photosensitizers Demonstrate Effective Two‐Photon Fluorescence Imaging and Photodynamic Therapy
Authors: Guo Luying , Guo Xing , Zuo Huiquan , Li Heng , Lv Fan , Wu Qinghua , Jiao Lijuan , Hao Erhong 
Published: April 2024

AbstractHypoxic tumor microenvironments pose significant challenges to the clinical translation of cancer photodynamic therapy (PDT). While heavy atom‐free Type‐I boron dipyrromethenes (BODIPYs) photosensitizers can alleviate this challenge by reducing oxygen dependency, but they remain scarce. Herein, heavy‐atom‐free α,meso‐linked bisBODIPYs were designed and synthesized. These bisBODIPYs exhibit remarkable red‐shifted emission (λemmax ~670 nm), large Stokes shifts (~4480 cm−1) and they are capable of producing both superoxide anion (O2⋅−) and singlet oxygen (1O2) in solution and cells. Additionally, they offer a wide PDT treatment window, ranging from 0.26 to 83.5 μM. Furthermore, these bisBODIPYs also demonstrate superior two‐photon fluorescence, promising for surgical navigation and integrating diagnosis with treatment.
A Zero‐Gap Gas Phase Photoelectrolyzer for CO2 Reduction with Porous Carbon Supported Photocathodes
Authors: Zhao Yujie , Merino‐Garcia Ivan , Albo Jonathan , Kaiser Andreas 
Published: April 2024

AbstractA modified Metal‐Organic Framework UiO‐66‐NH2‐based photocathode in a zero‐gap gas phase photoelectrolyzer was applied for CO2 reduction. Four types of porous carbon fiber layers with different wettability were employed to tailor the local environment of the cathodic surface reactions, optimizing activity and selectivity towards formate, methanol, and ethanol. Results are explained by mass transport through the different type and arrangement of carbon fiber support layers in the photocathodes and the resulting local environment at the UiO‐66‐NH2 catalyst. The highest energy‐to‐fuel conversion efficiency of 1.06 % towards hydrocarbons was achieved with the most hydrophobic carbon fiber (H23C2). The results are a step further in understanding how the design and composition of the photoelectrodes in photoelectrochemical electrolyzers can impact the CO2 reduction efficiency and selectivity.
Impact of the COVID‐19 pandemic on the treatment of acute cholangitis caused by choledocholithiasis: A single‐center retrospective study in Japan
Authors: Hanatani Jun‐ichi , Kitagawa Koh , Tomooka Fumimasa , Asada Shohei , Mitoro Akira , Fujinaga Yukihisa , Nishimura Norihisa , Sato Shinya , Shibamoto Akihiko , Fujimoto Yuki , Kubo Takahiro , Iwai Satoshi , Tsuji Yuki , Namisaki Tadashi , Akahane Takemi , Kaji Kosuke , Tanaka Misako , Koizumi Aritoshi , Yorioka Nobuyuki , Matsuda Takuya , Masuda Hiroyuki , Takami Masayoshi , Kikuchi Mayuko , Kawanishi Mariya , Ohoka Kazutaka , Watanabe Daisuke , Kawasaki Akane , Yoshiji Hitoshi 
Published: April 2024

AbstractObjectivesThis study aimed to determine the impact of the coronavirus disease 2019 (COVID‐19) pandemic on the treatment of acute cholangitis caused by choledocholithiasis.MethodsThe Japanese government declared a state of emergency in April 2020 due to the COVID‐19 pandemic. We retrospectively reviewed the medical records of 309 patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) for acute cholangitis caused by choledocholithiasis between April 2017 and December 2022.ResultsPatients were categorized into a pregroup (n = 134) and a postgroup (n = 175), depending on whether they were diagnosed before or after the state of emergency declaration. The total number of ERCP cases and the number of ERCP cases with endoscopic stone removals increased after the state of emergency declaration. Compared with the pregroup, the numbers of patients with performance status of 0–1 and surgically altered anatomy increased, whereas the numbers of patients taking oral antiplatelets or anticoagulants and those with cerebrovascular disease decreased in the postgroup. The number of single‐stage endoscopic stone removals increased and hospital stays were significantly shorter in the postgroup. No differences in adverse event rates were detected between the two groups.ConclusionsAlthough our hospital provides tertiary care, the number of patients with cholangitis in good general condition and no underlying disease increased after the state of emergency declaration. The COVID‐19 pandemic resulted in an increase in the number of single‐stage endoscopic treatments and shortened hospital stays for patients with acute cholangitis caused by choledocholithiasis. No safety issues with ERCP were detected, even during the pandemic.
Endoscopic ultrasound‐guided tissue acquisition for focal liver lesions in patients with a history of multiple primary malignant neoplasms
Authors: Takano Yuichi , Tamai Naoki , Yamawaki Masataka , Noda Jun , Azami Tetsushi , Niiya Fumitaka , Nishimoto Fumiya , Maruoka Naotaka , Yamagami Tatsuya , Nagahama Masatsugu 
Published: April 2024

AbstractObjectiveThis study aimed to investigate the usefulness of endoscopic ultrasound‐guided tissue acquisition (EUS‐TA) for diagnosing focal liver lesions in patients with a history of multiple primary malignant neoplasms.MethodsAmong patients who underwent EUS‐TA for focal liver lesions between 2016 and 2022, those with a history of multiple malignant neoplasms were included. A histologically confirmed malignant tumor within the past 5 years before EUS‐TA was defined as a history of malignant neoplasm. The primary outcomes were diagnostic ability and adverse events of EUS‐TA.ResultsThis study included 16 patients (median age, 73 [33–90] years), the median tumor size was 32 (6–51) mm, 14 had a history of double malignant neoplasms, whereas two had triple malignant neoplasms. Malignant neoplasms were detected histologically or cytologically in all cases. Immunohistochemistry was performed in 75% (12/16), and the final diagnosis of EUS‐TA was metastatic liver tumor in 12 patients, and primary malignant liver tumor in four patients. The primary site could be identified in 11 of 12 metastatic tumor cases. The diagnostic yield of EUS‐TA was 100% (16/16) for differentiating benign and malignant tumors and 94% (15/16) for confirming the histological type including the primary site of metastatic lesions. No adverse events were associated with the procedure.ConclusionEUS‐TA is a useful diagnostic modality for focal liver lesions in patients with a history of multiple malignant neoplasms, allowing for the differential diagnosis of primary and metastatic tumors and identification of the primary site of metastatic lesions.
Evaluating haemodynamic changes: vericiguat in patients with heart failure with reduced ejection fraction
Authors: Suzuki Hideaki , Inoue Takumi , Terui Yousuke , Takeuchi Kouki , Susukita Kai , Arai Marina , Sato Haruka , Satoh Taijyu , Yamamoto Saori , Yaoita Nobuhiro , Tatebe Shunsuke , Hayashi Hideka , Nochioka Kotaro , Takahama Hiroyuki , Yasuda Satoshi 
Published: April 2024

AbstractAimsVericiguat has been used to treat patients with heart failure with reduced ejection fraction (HFrEF) who demonstrated worsening heart failure despite treatment with other guideline‐directed medical therapies. The haemodynamic effects of vericiguat remain unclear.Methods and resultsThis study enrolled 12 patients (median age, 63 [quartiles 53.5, 70] years; 16.7%(N=2) women) with symptomatic HFrEF (New York Heart Association functional class II–IV) who demonstrated worsening heart failure despite treatment with the four foundational guideline‐recommended therapies between March and December 2022, with follow‐ups completed in June 2023. A balloon‐tipped pulmonary artery thermodilution catheter was placed in the right internal jugular vein to perform right heart catheterisation (RHC) on day 1. Haemodynamic data were acquired before and after vericiguat intake (2.5 mg) on days 2 and 3. The data on days 2 and 3 were averaged. RHC was repeated on day 105 (37, 168). Oral intake of vericiguat 2.5 mg decreased mean pulmonary artery pressure (19.3 [14.3, 26.8] mmHg) and pulmonary artery wedge pressure (PAWP) (11 [7.5, 15] mmHg) before the intake to mean pulmonary artery pressure (17.5 [12.5, 24] mmHg) and PAWP (9.3 [6.8, 14] mmHg) at 30 min after (both P < 0.05). Reduction in PAWP was also found from 14.5 [9.5, 19.5] mmHg on day 1 to 9.5 [6.5, 12.5] mmHg on day 105 (37, 168) (P < 0.05), when vericiguat was titrated to 2.5 mg 25% (N = 3), 5 mg 50% (N = 6), and 10 mg 25% (N = 3).ConclusionsThe consistent reduction in PAWP underscores the well‐tolerated nature of vericiguat and its potential to enhance cardiac performance in patients with HFrEF.
A novel intelligent risk prediction model for the effectiveness of CO2/N2–ECGD technology
Authors: Wang Xiaoyong , Wang Zhie , Xu Jingde , Ma Jun , Zhang Jun , Cai Zhuowen 
Published: April 2024

AbstractTo solve the problems of high sampling requirements and low predictive accuracy resulting from the complexity, uniqueness, and randomness of predicting the risk of the CO2 and N2 injection to enhance coal seam gas drainage (CO2/N2–ECGD) technology. The principal component analysis (PCA) method to reduce the dimensionality of the factor data that contribute to the effect risk of the technology was adopted. And the particle swarm optimization (PSO) method was implemented to search for optimal hyperparameters in support vector machine (SVM) by particle search, as a solution to the traditional SVM hyperparameters optimization problem. A novel risk prediction model using machine learning algorithms for gas injection displacement technology was constructed. The prediction results were tested and compared with those of backpropagation (BP), Random Forest (RF), and Decision Tree (DT) models using data from 29 gas injection displacement field projects in China. The results demonstrated that the SVM model had greater accuracy in prediction than the other three models. Additionally, after PSO optimization and dimensionality reduction, the PCA–PSO–SVM model reached 100% prediction accuracy, while requiring less modeling and operation time. The study provided a reliable and reasonable model for predicting technical effects, along with a theoretical basis for risk management and prevention. First, the technology's influencing indicators were analyzed by examining its mechanisms. Second, we utilized the PCA method to reduce the dimensionality of the factor data that contribute to the risk of the technology's effects. Third, we implemented the PSO method to search for optimal hyperparameters in the SVM through particle search, as a solution to the traditional SVM hyperparameters optimization problem. Finally, the prediction results were tested and compared with those of BP, RF, and DT models using data from 29 gas injection displacement field projects in China. The SVM model was found to have greater accuracy in prediction than the other three models. After PSO optimization and dimensionality reduction, the PCA–PSO–SVM model achieved 100% prediction accuracy while requiring less modeling and operation time. The study presents a valid and reasonable model for predicting technical effects and a theoretical basis for risk management and prevention.
Strategic optimization operations in the integrated energy system through multitime scale comprehensive demand response
Authors: Zheng Boyuan , Hou Xiaowang , Xu Shouhan , Jin Tai , Liu Wenjie , Li Na , Guo Dongxu , Pan Chongchao 
Published: April 2024

AbstractIn the context of the dual carbon goal strategy, the proportion of new energy generation has increased annually, large‐scale renewable energy integration has been achieved, and the intermittent and uncertain operating characteristics pose an enormous challenge to the complete and stable operation of an integrated energy system (IES), promoting the complexity of IES optimization models. To increase the stability and accuracy of the system and improve the operation efficiency of the system, a Gaussian mixture model is used to fit the probability distribution of wind power and the prediction errors of the photovoltaic output. In addition, the expected maximization method is used to solve a model with hidden variables, the results show that the expectation maximization algorithm can improve the fitting accuracy, reduce the error caused by the subjective setting of the initial value, and make the fitting accuracy of the wind‐solar power prediction error greater. Then, to solve the problem in which the low resolution of the day‐ahead scheduling time leads to large errors, day‐ahead, day‐to‐day multitime scale operation optimization model takes into account the comprehensive demand response according to the differences in wind and solar output and load forecasting accuracy. Finally, simulation validation is conducted in multiple scenarios, and a comparative analysis is performed for single and multitime scale comprehensive demand response scenarios. The simulation results show that compared with the optimization results of no demand response day, the optimization results of this model reduce the total cost by 23.21%, carbon emissions by 13.98%, purchased electricity by 13.87%, and purchased gas by 19.31%, effectively improving the use of gas turbines in the system. The multitime scale scheduling strategy increases the overall operating cost of the IES, modifies the scheduling results, and agrees with real operating scenarios.
Geomorphic signatures of neotectonic activity along the Western Andean Front in the Chilean Andes (35°S to 37°S)
Authors: Oviedo‐Reyes Jorge Adrián , Cortés‐Aranda Joaquín , Fernandez Alfonso , Perez‐Peña José Vicente , Flores Laura 
Published: April 2024

AbstractCharacterizing neotectonic activity along mountain fronts in active orogens is the key to better understanding trajectories of landscape evolution, climatic‐tectonic couplings and natural hazards. One such prominent mountain front is the Western Andean Front (WAF), which defines the boundary between two main physiographic units along the Chilean Andes (15°S to 39°S): the Central Depression and Principal Cordillera. This study analyses the geomorphic imprints of neotectonic fault activity in the WAF between 35°S and 37°S. We used several topographic metrics, including the mountain‐front sinuosity index (Smf), the valley floor width‐to‐height ratio (Vf) and the stream length‐gradient (SL) index to gain information about the regional distribution of deformation patterns and its relative tectonic activity for distinctive segments. In addition, a raster map combining rock strength (RS) and mean annual precipitation (MAP) allowed discriminating lithology‐climate vs. tectonics influence on SL anomalies from catchments spanning from the main deformation zone to the regional drainage divide. We use the local relief and swath profiles to quantify the incision and transient state of mountain fronts to evaluate the geomorphic response to tectonic and/or climatic input. Our analysis highlights significant variations from north to south, delineating two distinct segments with different topographic, geomorphic and geometric fault characteristics. These segments are indented at approximately 36°S. From north to south, there is a segment with an inactive thrust front with a primarily climate‐driven fluvial response over long timescales and a second segment with a transient state adjusting to relatively high uplift rates. Morphometric data analysis, DEM‐based morpho‐structural maps, geological maps and previous research support the interpretation of two sets of neotectonic faults: (1) NNE‐striking reverse faults with a dextral slip component and (2) NW‐striking sinistral slip faults, likely a response to deformation partitioning caused by oblique subduction on a continental margin.
Fish Tissue Mercury in Lakes and the Moderating Effects of Selenium
Authors: Hughes Robert M. , Peterson (Retired) Spencer A. , Van Sickle (Retired) John , Herlihy Alan T. , Essig (Retired) Don A. 
Published: April 2024

Abstract
Fish mercury concentrations result in fish consumption advisories. However, selenium : mercury molar ratios &gt;1 are protective to wildlife and humans. Therefore, we sampled total selenium (TSe) and total mercury (THg) concentrations and molar ratios in sport fish from 50 Idaho (ID) lakes &gt;20 ha and 67 northeastern USA (NE) lakes &gt;1 ha. Sample lakes were selected at random, to obtain unbiased estimates of mean fish tissue levels, with known confidence limits, for target populations of 95 ID lakes &gt;20 ha in surface area and 12,557 NE lakes &gt;1 ha. Bass and salmonids presented the greatest potential mercury toxicity risk to consumers based on their higher mercury content, desirability as game fish, and widespread distributions. Fish tissue THg exceeded safe consumption criteria in an estimated 20–80% of the lakes in the two regions and TSe exceeded safe consumption thresholds in an estimated 0–20% of the lakes in the two regions. However, the Se : Hg molar ratio was &gt;1 in an estimated 90–97% of fish tested from NE and ID lakes. Therefore, we concluded that Se levels in these systems are usually sufficient to limit disruption of selenoprotein activities by Hg, and that fish consumption advisories based on Hg alone are unnecessarily restrictive.
Burnout levels and correlates among healthcare providers in Syria following the 2023 Turkish–Syrian earthquakes: A cross‐sectional study
Authors: Almohsen Caroline , Soqia Jameel , Mohsen Samer 
Published: April 2024

AbstractBackground and AimsThis article examines the prevalence of burnout among healthcare providers in the aftermath of the recent earthquakes in Syria and Turkey and explores the associated risk factors.MethodsThis cross‐sectional study included 270 healthcare providers in three Syrian cities damaged by earthquakes. Participants were asked to fill out a validated questionnaire on the fifth day of emergency response using the Geldard Occupational Burnout questionnaire.ResultsThe mean score for the Geldard Occupational Burnout Questionnaire was 129.79, with 81.4% indicating moderate burnout risk and only 3% indicating high risk. Gender was not significantly associated with burnout, but there was a significant difference in burnout scores between city groups, with Latakia scoring significantly lower than Aleppo.ConclusionThis study highlights the prevalence of burnout among healthcare providers in the aftermath of an earthquake in Syria, with the majority having a moderate risk of burnout. Gender was not significantly associated with burnout risk. Further research is needed to develop effective interventions and address study limitations. The study emphasizes the importance of prioritizing healthcare providers' mental health to ensure high‐quality care after natural disasters.
Second primary cancer risks according to race and ethnicity among U.S. breast cancer survivors
Authors: Brandt Carolyn , Vo Jacqueline B. , Gierach Gretchen L. , Cheng Iona , Torres Vanessa N. , Lawrence Wayne R. , McCullough Lauren E. , Veiga Lene H. S. , Berrington de González Amy , Ramin Cody 
Published: April 2024

AbstractBreast cancer survivors have an increased risk of developing second primary cancers, yet risks by race and ethnicity have not been comprehensively described. We evaluated second primary cancer risks among 717,335 women diagnosed with first primary breast cancer (aged 20–84 years and survived ≥1‐year) in the SEER registries using standardized incidence ratios (SIRs; observed/expected). SIRs were estimated by race and ethnicity compared with the racial‐ and ethnic‐matched general population, and further stratified by clinical characteristics of the index breast cancer. Poisson regression was used to test for heterogeneity by race and ethnicity. SIRs for second primary cancer differed by race and ethnicity with the highest risks observed among non‐Hispanic/Latina Asian American, Native Hawaiian, or other Pacific Islander (AANHPI), non‐Hispanic/Latina Black (Black), and Hispanic/Latina (Latina) survivors and attenuated risk among non‐Hispanic/Latina White (White) survivors (SIRAANHPI = 1.49, 95% CI = 1.44–1.54; SIRBlack = 1.41, 95% CI = 1.37–1.45; SIRLatina = 1.45, 95% CI = 1.41–1.49; SIRWhite = 1.09, 95% CI = 1.08–1.10; p‐heterogeneity<.001). SIRs were particularly elevated among AANHPI, Black, and Latina survivors diagnosed with an index breast cancer before age 50 (SIRs range = 1.88–2.19) or with estrogen receptor‐negative tumors (SIRs range = 1.60–1.94). Heterogeneity by race and ethnicity was observed for 16/27 site‐specific second cancers (all p‐heterogeneity's < .05) with markedly elevated risks among AANHPI, Black, and Latina survivors for acute myeloid and acute non‐lymphocytic leukemia (SIRs range = 2.68–3.15) and cancers of the contralateral breast (SIRs range = 2.60–3.01) and salivary gland (SIRs range = 2.03–3.96). We observed striking racial and ethnic differences in second cancer risk among breast cancer survivors. Additional research is needed to inform targeted approaches for early detection strategies and treatment to reduce these racial and ethnic disparities.
Changes in therapists’ client dropout rates over time: Findings from a practice‐research group
Authors: Bugatti Matteo , Owen Jesse , Richardson Zachary , Rasmussen Wendy , Newton Douglas A. 
Published: April 2024

AbstractResearch has failed to consistently show that therapists facilitate better client outcomes as they gain more experience. The present study was designed to examine changes in early client retention over the course of extended periods of time among 2591 therapists in private practice. Naturalistic data collected between 2018 and 2022 was extracted from a technology‐enabled practice‐research group (PRG). Therapists displayed an increase in client dropout rates as they gained more experience on the PRG. Additionally, larger caseloads on the PRG were associated with lower increases in client dropout over time. Finally, therapists working with clients paying higher out‐of‐pocket fees (e.g., co‐pays) had higher increases in client dropout over time. These findings provide additional evidence supporting the distinction between clinical experience and expertise.
Pharmacokinetic, Pharmacodynamic, and Safety Profiles of Proline Henagliflozin in Chinese Subjects with Varying Degrees of Liver Dysfunction
Authors: Ding Likun , Yang Lin , Ren Danjun , Gao Xiaohua , Zhang Juanli , Liu Meiyou , Sun Li , Diao Qingbo , Feng Sheng , Wen Aidong , Wang Jingwen 
Published: April 2024

AbstractProline henagliflozin, a novel selective inhibitor of sodium glucose cotransporter 2, is a treatment for type 2 diabetes mellitus. We designed a parallel‐group, open‐label, and multicenter study to evaluate the pharmacokinetic (PK), pharmacodynamic (PD), and safety profiles of henagliflozin in Chinese subjects with varying degrees of liver dysfunction. Thirty‐two subjects were enrolled and divided into four groups based on liver function (normal liver function, mild, moderate, or severe liver dysfunction). The area under the plasma concentration from time zero to infinity of henagliflozin in subjects with mild liver dysfunction, moderate liver dysfunction, and severe liver dysfunction compared with normal liver function was increased by 137%, 197%, and 204%, respectively. The maximum plasma concentration was also increased by 123%, 129%, and 139%, respectively. PK parameters of three metabolites varied to different degrees in the liver dysfunction groups than in the normal liver function group. The mean accumulative excretion amounts and fraction of dose excreted in urine expressed as a percentage were all increased with the decrease of liver function. The PD parameters were significantly higher in liver dysfunction groups than those in the normal liver function group. However, the urine creatinine (UCr) was not significantly different among the groups. No notable adverse events or adverse drug reactions were observed. Due to the higher exposures in subjects with liver dysfunction, the benefit: risk ratio should be individually assessed because the long‐term safety profile and efficacy have not been specifically studied in this population.