bluuebunny/crossref_metadata_2025_split huggingface dataset:
International experiential diversity and performance at project organizations
Authors: Ruigrok Winfried , Greve Peder , Engeler Martin 
Published: October 2011

PurposeThe purpose of this paper is to shed new light on the link between diversity in project teams and team performance by examining the effects of players’ international career diversity on the performance of national football teams.Design/methodology/approachThe paper draws upon the literature on project organizations and experiential diversity in teams. Using data on players’ international career backgrounds and team performance from the FIFA World Cup 2006, the authors test two hypotheses linking experiential diversity in teams and a measure of relative team performance. The dataset includes detailed individual background profiles of the 736 participating players and performance data from the 64 games played at the tournament.FindingsThe findings suggest that different types of experiential diversity have contrasting effects on team performance in a time‐limited project team setting.Research limitations/implicationsThese findings encourage team diversity researchers to further examine the impact of experiential diversity in teams on team process and performance outcomes in future research.Practical implicationsThe findings particularly highlight the need to carefully manage experiential diversity in project team settings in order to benefit from access to diverse tacit resources, while at the same time avoiding that the integrative capacities of teams becoming overstretched.Originality/valueThe paper is a step towards a better understanding of how diversity of individual career backgrounds affects team performance outcomes in project teams.
Multidetector row helical computed tomography for invasive ductal carcinoma of the breast: Correlation between radiological findings and the corresponding biological characteristics of patients
Authors: Tamaki Kentaro , Ishida Takanori , Miyashita Minoru , Amari Masakazu , Mori Naoko , Ohuchi Noriaki , Tamaki Nobumitsu , Sasano Hironobu 
Published: October 2011

The aim of this study is to evaluate the correlation between multidetector row helical computed tomography (MDCT) findings and the histopathological characteristics of patients with invasive ductal carcinoma. We retrospectively reviewed MDCT findings and the corresponding histopathological features of 442 women with invasive ductal carcinoma. We received informed consent from the patients and the protocol was approved by the Ethics Committee at Tohoku University. The median age was 53 years (26–89 years). We examined the MDCT findings based on mass shape classified into well, moderate, poorly and scattered demarcated shapes, the enhancement pattern classified into homogenous, heterogeneous, rim and poor, and mass density classified into high, intermediate or low. We subsequently compared these radiological findings with the histological characteristics and clinical outcome. Poorly demarcated types were higher in ER+/HER2− (P = 0.008), while the well‐demarcated type was higher in ER−/HER2− and ER−/HER2+ (P < 0.001 and P = 0.010). Rim pattern was higher in ER−/HER2− (P < 0.001). Intermediate or low density was higher in ER−/HER2− (P < 0.001, respectively). Further analysis based on histological grade, mitotic counts and lymphovascular invasion demonstrated that the well‐demarcated shape was higher in grade 2 and 3 (P = 0.006 and P < 0.001, respectively), and rim pattern was observed in grade 3 (P < 0.001). Regarding mitotic counts, poorly and scattered demarcated shapes were observed in score 1 (P = 0.008 and P = 0.014), while well‐demarcated shape and rim enhancement were observed in score 3 (P < 0.001, respectively). Lymphovascular invasion correlated with a moderate demarcated shape (P = 0.029). Regarding recurrence rates, there were statistically significant differences between well and moderate, poorly or scattered demarcated shapes (P = 0.007, 0.028 and 0.035, respectively). These proposed MDCT diagnostic criteria based on biological characteristics contribute to more accurately predicting the biological behavior of breast cancer patients. (Cancer Sci 2012; 103: 67–72)
Platelet doubling after the first azacitidine cycle is a promising predictor for response in myelodysplastic syndromes (MDS), chronic myelomonocytic leukaemia (CMML) and acute myeloid leukaemia (AML) patients in the Dutch azacitidine compassionate named patient programme
Authors: van der Helm Lieke H. , Alhan Canan , Wijermans Pierre W. , van Marwijk Kooy Marinus , Schaafsma Ron , Biemond Bart J. , Beeker Aart , Hoogendoorn Mels , van Rees Bastiaan P. , de Weerdt Okke , Wegman Jurgen , Libourel Ward J. , Luykx‐de Bakker Sylvia A. , Minnema Monique C. , Brouwer Rolf E. , Croon‐de Boer Fransien , Eefting Matthijs , Jie Kon‐Siong G. , van de Loosdrecht Arjan A. , Koedam Jan , Veeger Nic J. G. M , Vellenga Edo , Huls Gerwin 
Published: October 2011

SummaryThe efficacy of azacitidine in the treatment of high‐risk myelodysplastic syndromes (MDS), chronic myelomonocytic leukaemia (CMML) and acute myeloid leukaemia (AML) (20–30% blasts) has been demonstrated. To investigate the efficacy of azacitidine in daily clinical practice and to identify predictors for response, we analysed a cohort of 90 MDS, CMML and AML patients who have been treated in a Dutch compassionate named patient programme. Patients received azacitidine for a median of five cycles (range 1–19). The overall response rate (complete/partial/haematological improvement) was 57% in low risk MDS, 53% in high risk MDS, 50% in CMML, and 39% in AML patients. Median overall survival (OS) was 13·0 (9·8–16·2) months. Multivariate analysis confirmed circulating blasts [Hazard Ratio (HR) 0·48, 95% confidence interval (CI) 0·24–0·99; P = 0·05] and poor risk cytogenetics (HR 0·45, 95% CI 0·22–0·91; P = 0·03) as independent predictors for OS. Interestingly, this analysis also identified platelet doubling after the first cycle of azacitidine as a simple and independent positive predictor for OS (HR 5·4, 95% CI 0·73–39·9; P = 0·10). In conclusion, routine administration of azacitidine to patients with variable risk groups of MDS, CMML and AML is feasible, and subgroups with distinct efficacy of azacitidine treatment can be identified.
The potential role of Aurora kinase inhibitors in haematological malignancies
Authors: Farag Sherif S. 
Published: October 2011

SummaryAurora kinases play an important role in the control of the cell cycle and have been implicated in tumourigenesis in a number of cancers. Among the haematological malignancies, overexpression of Aurora kinases has been reported in acute myeloid leukaemia, chronic myeloid leukaemia, acute lymphoblastic leukaemia, multiple myeloma, aggressive non‐Hodgkin lymphoma and Hodgkin lymphoma. A large number of Aurora kinase inhibitors are currently in different stages of clinical development. In addition to varying in their selectivity for the different Aurora kinases, some also have activity directed at other cellular kinases involved in important molecular pathways in cancer cells. This review summarizes the biology of Aurora kinases and discusses why they may be good therapeutic targets in different haematological cancers. We describe preclinical data that has served as the rationale for investigating Aurora kinase inhibitors in different haematological malignancies, and summarize published results from early phase clinical trials. While the anti‐tumour effects of Aurora kinase inhibitors appear promising, we highlight important issues for future clinical research and suggest that the optimal use of these inhibitors is likely to be in combination with cytotoxic agents already in use for the treatment of various haematological cancers.
Cumulative flying time and risk of venous thromboembolism
Authors: MacCallum Peter K. , Ashby Deborah , Hennessy Enid M. , Letley Louise , Martin Jeannett , Mt‐Isa Shahrul , Vickers Madge R. , Whyte Ken 
Published: October 2011

SummaryThe risk of venous thromboembolism (VTE) associated with cumulative flying time remains uncertain. In a case–control study in general practices throughout the UK, participants comprised 550 VTE cases identified from practice records and 1971 age‐ and gender‐matched controls. Participants returned identical questionnaires asking for information including air travel details. Compared to not flying, cumulative flying time >12 h within the previous 4 weeks was associated with a threefold increase in the risk of VTE [odds ratio (OR) 2·75, 95% confidence interval (CI), 1·44–5·28]. Those who had flown >4 h in a single leg in the previous 4 weeks had twice the risk of VTE (OR 2·20, 95% CI, 1·29–3·73). These risks were no longer evident by 12 weeks and were similar to those of day‐case or minor surgery (OR 5·35, 95% CI, 2·15–13·33). Equivalent risks for moderate and high‐risk surgery were over 30‐fold (OR 36·57, 95% CI, 13·05–102·52) and 140‐fold (OR 141·71, 95% CI, 19·38–1036·01) respectively. The temporary nature of the association of cumulative and long‐haul air travel with VTE suggests a causal relationship. The risks of VTE in those with a higher baseline risk due to surgery, previous VTE or obesity are further increased by air travel.
Time will tell: a retrospective study investigating the relationship between insomnia and objectively defined punctuality
Authors: SPIEGELHALDER KAI , REGEN WOLFRAM , KYLE SIMON D. , ENDRES DOMINIQUE , NISSEN CHRISTOPH , FEIGE BERND , RIEMANN DIETER 
Published: October 2011

SummaryPrimary insomnia is a prevalent sleep disorder affecting approximately 3% of the general population. Studies suggest that personality traits such as perfectionism and neuroticism might be implicated in the aetiology of the disorder. However, to date, no study has investigated behavioural indicators of these factors in a hypothesis‐driven manner. In the present study, we assessed punctuality as a behavioural indicator of perfectionism and neuroticism in 635 consecutive clinical patients of the sleep laboratory of the Department of Psychiatry and Psychotherapy, University of Freiburg Medical Center. The primary aim was to compare primary insomnia patients (n = 148) with another group of patients with other sleep‐related diagnoses (n = 487). Primary insomnia patients arrived on average 4 min earlier when compared to other patients (P = 0.041). However, this effect failed to reach statistical significance when correcting for the influence of potential confounding variables. Of note, we found a strong relationship between polysomnographic sleep parameters and punctuality. That is, short sleep duration was associated significantly with early arrival times at the sleep laboratory (P = 0.023). These findings support the proposal that personality traits, which we predict underlie obsessive punctuality, may be involved in the aetiology of objectively defined sleep disturbances. Clinical implications of the current results for cognitive behavioural treatments of insomnia are discussed.
Short‐term outcome after gluteus maximus myocutaneous flap reconstruction of the pelvic floor following extra‐levator abdominoperineal excision of the rectum
Authors: Anderin C. , Martling A. , Lagergren J. , Ljung A. , Holm T. 
Published: October 2011

AbstractAim  Extra‐levator abdominoperineal excision (APE) of the rectum has been introduced with the aim of improving the oncological outcome of low rectal cancer. The procedure includes resection of the levator muscles en bloc with the mesorectum, leaving a larger perineal defect than after conventional APE. This study reports short‐term outcome of gluteus maximus myocutaneous flap reconstruction on perineal wound healing.Method  Sixty‐five patients were studied after extra‐levator APE and a one‐sided myocutaneous flap for a low or locally recurrent rectal cancer at the Karolinska University Hospital from January 2002 to December 2008. Fifty‐nine had received neoadjuvant radio‐ or radiochemotherapy. All perineal complications occurring within 30 days after surgery were registered. In addition, the status of the perineal reconstruction at 6 months and 1 year after surgery was assessed based on medical records from outpatient visits.Results  Twenty‐seven (41.5%) patients had one or more perineal wound complications. A minor wound infection occurred in 15, while 12 had either a more severe infection with dehiscence or a pelvic abscess. The reconstruction was completely healed in 91% of the patients at 1 year.Conclusion  Although the vast majority of the perineal reconstructions were healed at 1 year, the short‐term perineal wound complication rate of gluteus maximus flap reconstruction was high.
Metabolic Modulation of Cytokine‐Induced Brain Endothelial Adhesion Molecule Expression
Authors: CHAITANYA GANTA VIJAY , CROMER WALTER , WELLS SHANNON , JENNINGS MERILYN , MATHIS JAMES M , MINAGAR ALIREZA , ALEXANDER JONATHAN STEVEN 
Published: October 2011

Please cite this paper as: Chaitanya GV, Cromer W, Wells S, Jennings M, Mathis JM, Minagar A and Alexander JS. Metabolic Modulation of Cytokine‐Induced Brain Endothelial Adhesion Molecule Expression. Microcirculation 19: 155–165, 2012.AbstractObjective:  Cytokines contribute to cerebro‐vascular inflammatory and immune responses by inducing ECAMs’ expression. Ischemic insults can be separated into aglycemic and hypoxic components. However, whether aglycemia, hypoxia or OGD plays a major role in dysregulating BBB or promotes immune cell infiltration via ECAMs’ expression is not clear. We investigated how expression of ICAM‐1, VCAM‐1, MAdCAM‐1, PECAM‐1, E‐ and P‐selectin in response to TNF‐α, IL‐1β and IFN‐γ was altered by aglycemia (A), hypoxia (H) or combined oxygen glucose deprivation (OGD).Methods:  A cell surface enzyme linked immunoabsorbent assay (cell surface ELISA) was used to analyze ECAM expression.Results:  We observed that ICAM‐1 and PECAM‐1 expressions were insensitive to hypoxia, aglycemia or OGD. Conversely, VCAM‐1 and E‐selectin were increased by hypoxia, but not by aglycemia. MAdCAM‐1 and P‐selectin were induced by hypoxia, and decreased by aglycemia. Patterns of cytokine‐regulated ECAMs’ expression were also modified by metabolic conditions.Conclusions:  Our results indicate that patterns of inflammation‐associated ECAMs represent cumulative influences from metabolic stressors, as well as cytokine activation. The expression of ECAMs following tissue injury reflects mechanistic interactions between metabolic disturbances, and alterations in tissue cytokines. Normalization of tissue metabolism, as well as cytokine profiles, may provide important targets for therapeutic treatment of inflammation.
Evidence of Differences between the Communities of Arbuscular Mycorrhizal Fungi Colonizing Galls and Roots of Prunus persica Infected by the Root-Knot Nematode Meloidogyne incognita
Authors: Alguacil Maria del Mar , Torrecillas Emma , Lozano Zenaida , Roldán Antonio 
Published: October 2011

ABSTRACT

Arbuscular mycorrhizal fungi (AMF) play important roles as plant protection agents, reducing or suppressing nematode colonization. However, it has never been investigated whether the galls produced in roots by nematode infection are colonized by AMF. This study tested whether galls produced by
Meloidogyne incognita
infection in
Prunus persica
roots are colonized by AMF. We also determined the changes in AMF composition and biodiversity mediated by infection with this root-knot nematode. DNA from galls and roots of plants infected by
M. incognita
and from roots of noninfected plants was extracted, amplified, cloned, and sequenced using AMF-specific primers. Phylogenetic analysis using the small-subunit (SSU) ribosomal DNA (rDNA) data set revealed 22 different AMF sequence types (17
Glomus
sequence types, 3
Paraglomus
sequence types, 1
Scutellospora
sequence type, and 1
Acaulospora
sequence type). The highest AMF diversity was found in uninfected roots, followed by infected roots and galls. This study indicates that the galls produced in
P. persica
roots due to infection with
M. incognita
were colonized extensively by a community of AMF, belonging to the families Paraglomeraceae and Glomeraceae, that was different from the community detected in roots. Although the function of the AMF in the galls is still unknown, we hypothesize that they act as protection agents against opportunistic pathogens.
Stimulation of Methanotrophic Growth in Cocultures by Cobalamin Excreted by Rhizobia
Authors: Iguchi Hiroyuki , Yurimoto Hiroya , Sakai Yasuyoshi 
Published: October 2011

ABSTRACTMethanotrophs play a key role in the global carbon cycle, in which they affect methane emissions and help to sustain diverse microbial communities through the conversion of methane to organic compounds. To investigate the microbial interactions that cause positive effects on methanotrophs, cocultures were constructed usingMethylovulum miyakonenseHT12 and each of nine nonmethanotrophic bacteria, which were isolated from a methane-utilizing microbial consortium culture established from forest soil. Three rhizobial strains were found to strongly stimulate the growth and methane oxidation ofM. miyakonenseHT12 in cocultures. We purified the stimulating factor produced byRhizobiumsp. Rb122 and identified it as cobalamin. Growth stimulation by cobalamin was also observed for three other gammaproteobacterial methanotrophs. These results suggest that microbial interactions through cobalamin play an important role in methane oxidation in various ecosystems.
Tricholoma matsutake Dominates Diverse Microbial Communities in Different Forest Soils
Authors: Vaario Lu-Min , Fritze Hannu , Spetz Peter , Heinonsalo Jussi , Hanajík Peter , Pennanen Taina 
Published: October 2011

ABSTRACT

Fungal and actinobacterial communities were analyzed together with soil chemistry and enzyme activities in order to profile the microbial diversity associated with the economically important mushroom
Tricholoma matsutake
. Samples of mycelium-soil aggregation (shiro) were collected from three experimental sites where sporocarps naturally formed. PCR was used to confirm the presence and absence of matsutake in soil samples. PCR-denaturing gradient gel electrophoresis (DGGE) fingerprinting and direct sequencing were used to identify fungi and actinobacteria in the mineral and organic soil layers separately. Soil enzyme activities and hemicellulotic carbohydrates were analyzed in a productive experimental site. Soil chemistry was investigated in both organic and mineral soil layers at all three experimental sites. Matsutake dominated in the shiro but also coexisted with a high diversity of fungi and actinobacteria.
Tomentollopsis
sp. in the organic layer above the shiro and
Piloderma
sp. in the shiro correlated positively with the presence of
T. matsutake
in all experimental sites. A
Thermomonosporaceae
bacterium and
Nocardia
sp. correlated positively with the presence of
T. matsutake
, and
Streptomyces
sp. was a common cohabitant in the shiro, although these operational taxonomic units (OTUs) did not occur at all sites. Significantly higher enzyme activity levels were detected in shiro soil. These enzymes are involved in the mobilization of carbon from organic matter decomposition. Matsutake was not associated with a particular soil chemistry compared to that of nearby sites where the fungus does not occur. The presence of a significant hemicellulose pool and the enzymes to degrade it indicates the potential for obtaining carbon from the soil rather than tree roots.
Imaging and Analysis of Pseudomonas aeruginosa Swarming and Rhamnolipid Production
Authors: Morris Joshua D. , Hewitt Jessica L. , Wolfe Lawrence G. , Kamatkar Nachiket G. , Chapman Sarah M. , Diener Justin M. , Courtney Andrew J. , Leevy W. Matthew , Shrout Joshua D. 
Published: October 2011

ABSTRACT

Many bacteria spread over surfaces by “swarming” in groups. A problem for scientists who study swarming is the acquisition of statistically significant data that distinguish two observations or detail the temporal patterns and two-dimensional heterogeneities that occur. It is currently difficult to quantify differences between observed swarm phenotypes. Here, we present a method for acquisition of temporal surface motility data using time-lapse fluorescence and bioluminescence imaging. We specifically demonstrate three applications of our technique with the bacterium
Pseudomonas aeruginosa
. First, we quantify the temporal distribution of
P. aeruginosa
cells tagged with green fluorescent protein (GFP) and the surfactant rhamnolipid stained with the lipid dye Nile red. Second, we distinguish swarming of
P. aeruginosa
and
Salmonella enterica
serovar Typhimurium in a coswarming experiment. Lastly, we quantify differences in swarming and rhamnolipid production of several
P. aeruginosa
strains. While the best swarming strains produced the most rhamnolipid on surfaces, planktonic culture rhamnolipid production did not correlate with surface growth rhamnolipid production.
Inhibition of Staphylococcus aureus by Lysostaphin-Expressing Lactobacillus plantarum WCFS1 in a Modified Genital Tract Secretion Medium
Authors: Liu Huanli , Gao Yuan , Yu Li-Rong , Jones Richard C. , Elkins Christopher A. , Hart Mark E. 
Published: October 2011

ABSTRACTLactobacillusspecies are a predominant member of the vaginal microflora and are critical in maintaining an acidic vaginal environment thought to contribute to the prevention of a number of urogenital diseases. However, during menstruation the pH of the vaginal environment increases to neutrality, a pH conducive forStaphylococcus aureusproliferation and the production of toxic shock syndrome toxin 1 (TSST-1) in susceptible women. In order to generateLactobacillusspecies capable of expressing lysostaphin (an endopeptidase that cleaves the cell wall ofS. aureus) in a modified genital tract secretion medium (mGTS) under neutral-pH conditions, six prominent proteins fromLactobacillus plantarumWCFS1 spent medium were identified by mass spectrometry. Sequences for promoters, signal peptides, and mature lysostaphin were used to construct plasmids that were subsequently transformed intoL. plantarumWCFS1. The promoter and signal sequences of Lp_3014 (putatively identified as a transglycosylase) or the promoter sequence of Lp_0789 (putatively identified as glyceraldehyde 3-phosphate dehydrogenase) with the signal sequence of Lp_3014 exhibited lysostaphin activity on buffered medium containing heat-killedS. aureus. The cassettes were integrated into the chromosome ofL. plantarumWCFS1, but only the cassette containing the promoter and signal sequence from Lp_3014 had integrated into the appropriate site. Coculture assays using buffered mGTS showed that lysostaphin expressed fromL. plantarumWCFS1 reduced the growth of TSST-1-producing strains ofS. aureusunder neutral-pH conditions. This study provides the basis for determining whether lysostaphin-producingLactobacillusstrains could potentially be used as a means to inhibit the growth ofS. aureusduring menstruation.