bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carrots or sticks? Analyzing the application of US economic statecraft towards Latin American engagement with China
Authors: Zelicovich Julieta , Yamin Patricio 
Published: April 2024

AbstractGeopolitical competition between the United States and China has led to an increased reliance on economic statecraft. In this context, understanding the conditions that trigger trade, aid, or investment weaponization becomes crucial. This article examines how the United States has employed economic statecraft in response to Latin American countries’ engagement with China. The study revisits the theoretical debate on positive and negative economic statecraft and proposes a mechanism that identifies the conditions under which “carrots” or “sticks” are more likely to be employed. We argue that the US response towards Latin American countries’ engagement with China tends to prioritize economic engagement over economic coercion, particularly when dealing with countries that are politically and economically aligned with Washington policies. To test our argument, we adopt a mixed-methods approach. First, we conduct a case study analysis on the United States-Panama relationship. Second, we perform a statistical analysis to assess the impact of economic engagement with China on the allocation of American foreign assistance in the region.
Our experience of a speech and language therapist-led swallow disorder clinic
Authors: Smith Joseph , Smith Anita , McInally Karen , Kirkland Paul 
Published: April 2024

AbstractIntroductionDysphagia can lead to morbidity including weight loss and aspiration pneumonia. Effective triage of patients and streamlining of pathways to expedite diagnosis and treatment is therefore imperative.ObjectivesThe goals of this research were to measure the referral to treatment time for dysphagia patients in a newly established pathway and compare with existing UK national and local referral to treatment times, and to evaluate patient feedback.MethodsSpeech and language therapy advanced clinical practitioners were trained in nasendoscopy and assessment of swallow. Referral to treatment times were measured and patient satisfaction questionnaires completed.ResultsA decrease in triage to treatment time (from 24 to 6 weeks). Patients reported high understanding of the condition and minimal discomfort during assessments. Radiation exposure was reduced (2 per cent of patients undergoing soluble contrast swallows, previously 100 per cent).ConclusionThe new pathway expedites treatment and achieves high patient satisfaction. It empowers speech and language therapy in efficiently managing low-complexity cases and supports multidisciplinary care for dysphagia patients.
Falsity and untruth
Authors: van Inwagen Peter 
Published: April 2024

AbstractJc Beall's Divine Contradiction is a fascinating defence of the idea that contradictions are true of the tri-personal God. This project requires a logic that avoids the consequence that every proposition follows from a contradiction. Beall presents such a logic. This ‘gap/glut’ logic is the topic of this article. A gap/glut logic presupposes that falsity is not simply the absence of truth – for a proposition that is true may also be false. This article is essentially an examination of the idea that falsity is not simply untruth. The author rejects this position but does not claim to have an argument against it. In lieu of an argument, he presents three ‘considerations’. First, it is possible to give an intuitive semantics for the language of sentential logic that yields ‘classical’ sentential logic (including ‘p, ¬ p ⊢ q’) and which makes no mention of truth-values. Second, it is possible to imagine a race who manage their affairs very well without having the concept ‘falsity’. Third, it is possible to construct a semantics that yields a logic identical with the dialetheist logic and which makes no mention of truth-values – and which, far from being plausible, seems pointless.
Unravelling the nutritional transition in Spain: From meat shortages to excess (1958–1990)
Authors: Perea Pablo Delgado 
Published: April 2024

AbstractThe nutritional transition, together with the demographic and epidemiological transitions, stands as one of the most crucial phenomena shaping societies in the 20th century. A prominent characteristic of the nutritional transition is the increased consumption of animal-origin protein, particularly meat. Within this context, the present article utilises Spain as a case study to provide a close examination of the nutritional transition during the latter half of the 20th century. Spain’s significance lies in its late but rapid development of this transition. In the 1960s, meat consumption was relatively low compared to other European countries; however, within just two decades, it surpassed that of many developed nations. On one hand, the article offers a detailed insight into how budget constraints were eased to foster meat consumption among various consumer groups. On the other hand, the study aims to quantify the influence of income, prices, and preferences in driving this process
A parental communication assessment initiative in the paediatric cardiovascular ICU
Authors: Hansen Katherine , Jenkins Erin , Zhu Aihua , Collins Shawna , Williams Kimberly , Garcia Ariadna , Weng Yingjie , Kaufman Beth , Sacks Loren D. , Cohen Harvey , Shin Andrew Y. , Patel Meghna D. 
Published: April 2024

AbstractObjective:Challenges to communication between families and care providers of paediatric patients in intensive care units (ICU) include variability of communication preferences, mismatched goals of care, and difficulties carrying forward family preferences from provider to provider. Our objectives were to develop and test an assessment tool that queries parents of children requiring cardiac intensive care about their communication preferences and to determine if this tool facilitates patient-centred care and improves families’ ICU experience.Design:In this quality improvement initiative, a novel tool was developed, the Parental Communication Assessment (PCA), which asked parents with children hospitalised in the cardiac ICU about their communication preferences. Participants were prospectively randomised to the intervention group, which received the PCA, or to standard care. All participants completed a follow-up survey evaluating satisfaction with communication.Main Results:One hundred thirteen participants enrolled and 56 were randomised to the intervention group. Participants who received the PCA preferred detail-oriented communication over big picture. Most parents understood the daily discussions on rounds (64%) and felt comfortable expressing concerns (68%). Eighty-six percent reported the PCA was worthwhile. Parents were generally satisfied with communication. However, an important proportion felt unprepared for difficult decisions or setbacks, inadequately included or supported in decision-making, and that they lacked control over their child’s care. There were no significant differences between the intervention and control groups in their communication satisfaction results.Conclusions:Parents with children hospitalised in the paediatric ICU demonstrated diverse communication preferences. Most participants felt overall satisfied with communication, but individualising communication with patients’ families according to their preferences may improve their experience.
Introduction to the 20th Anniversary Special Issue of the Journal of Pension Economics and Finance
Authors: Rauh Joshua 
Published: April 2024

AbstractThe papers in this 20th Anniversary Special Issue reflect to a large extent how the fields of pension economics and pension finance have developed in the past two decades, although there remain very clear connections to the research published in the Journal's first issue. While there has been great progress in research on pensions and retirement economics over the last 20 years, there remain important outstanding questions for future study.
The British (and International?) Music Society: Australian Identity and Musical Internationalism in Interwar Sydney
Authors: KIRBY SARAH 
Published: April 2024

AbstractIn the aftermath of the First World War, Henri Verbrugghen founded the first Australian branch of the British Music Society. The BMS – a product of post-First World War cultural renewal – was established in London to ‘champion the cause of British composers at home and abroad’. In Sydney, these aspirations extended to promoting music from Australia, and through affiliation with the International Society for Contemporary Music, music of the rest of the world. This article explores the activities of the Sydney BMS, situating these within contemporary discourses of nationalism and internationalism in the construction of interwar Australian cultural identity. It argues that the sometimes conflicting aims of the society reflect a wider political and social ambivalence about Australia's place in the international landscape. While its primary goal was to champion local composers, this was held in uneasy balance with a desire to promote British music ‘proper’.
Supercells and Tornado‐Like Vortices in an Idealized Global Atmosphere Model
Authors: Cheng Kai‐Yuan , Lin Shian‐Jiann , Harris Lucas , Zhou Linjiong 
Published: April 2024

AbstractWe investigate the representation of individual supercells and intriguing tornado‐like vortices in a simplified, locally refined global atmosphere model. The model, featuring grid stretching, can locally enhance the model resolution and reach cloud‐resolving scales with modest computational resources. Given a conditionally unstable sheared environment, the model can simulate supercells realistically, with a near‐ground vortex and funnel cloud at the center of a rotating updraft reminiscent of a tornado. An analysis of the Eulerian vertical vorticity budget suggests that the updraft core of the supercell tilts horizontal vorticity into the tornado‐like vortex, which is then amplified through vertical stretching by the updraft. Results suggest that the simulated vortex is dynamically similar to observed tornadoes, as well as those simulated in modeling studies at much higher horizontal resolution. Lastly, we discuss the prospects for the study of cross‐scale interactions involving supercells.
Evaluation of Wildfire Plume Injection Heights Estimated from Operational Weather Radar Observations Using Airborne Lidar Retrievals
Authors: Krishna M. , Saide P. E. , Ye X. , Turney F. A. , Hair J. W. , Fenn M. , Shingler T. 
Published: April 2024

AbstractThe vertical distribution of wildfire smoke aerosols is important in determining its environmental impacts but existing observations of smoke heights generally do not possess the temporal resolution required to fully resolve the diurnal behavior of wildfire smoke injection. We use Weather Surveillance Radar‐1988 Doppler (WSR‐88D) dual polarization data to estimate injection heights of Biomass Burning Debris (BBD) generated by fires. We detect BBD as a surrogate for smoke aerosols, which are often collocated with BBD near the fire but are not within the size range detectable by these radars. Injection heights of BBD are derived for 2–10 August 2019, using WSR‐88D reflectivity (Z ≥ 10 dBZ) and dual polarization correlation coefficients (0.2 < C.C < 0.9) to study the Williams Flats fire. Results show the expected diurnal cycles with maximum injection heights present during the late afternoon period when the fire's intensity and convective mixing are maximized. WSR‐88D and airborne lidar injection height comparisons reveal that this method is sensitive to outliers and generally overpredicts maximum heights by 40%, though mean and median heights are better captured (<20% mean error). WSR‐88D heights between the 75th and 90th percentile seem to accurately represent the maximum heights, with the exception of heights estimated during the occurrence of a pyro‐cumulonimbus. Location specific mapping of WSR‐88D and lidar injection heights reveal that they diverge further away from the fire as expected due to BBD settling. Most importantly, WSR‐88D‐derived injection height estimates provide near continuous smoke height information, allowing for the study of diurnal variability of smoke injections.
An Approach for Assessing Human Respiration CO2 Emissions Using Radiocarbon Measurements and Bottom‐Up Data Sets
Authors: Wang Peng , Zhou Weijian , Niu Zhenchuan , Huo Da , Zhou Jie , Li Haogen , Cheng Peng , Wu Shugang , Xiong Xiaohu , Chen Ning 
Published: April 2024

AbstractCarbon dioxide (CO2) is a major greenhouse gas in the atmosphere and has large impacts on climate change. Its fossil fuel (CO2ff) and biogenic (CO2bio) sources are well investigated, while CO2 emissions from human respiration (CO2hr), a subset of CO2bio, have received less attention. Especially as a source of carbon emissions in densely populated megacities, the role of CO2hr emissions in the carbon cycles was largely neglected. Here we fully characterize the respiratory CO2 emission rates (CERs) of Chinese people for the first time. Using the example of the megacity Beijing in China, we estimate the CO2hr emissions and present a method for quantifying its fraction in the atmospheric CO2 based on radiocarbon (14C) measurements and inventory data sets. The results show that males and females have similar age trends in CERs, but the gender difference is significant, especially between the ages of 20 and 60, the average CERs was 33% higher for males than for females (P < 0.05). The CO2hr emissions were about 22.2 ± 0.6 kt CO2 per day, which was equivalent to 7.5% of daily CO2ff emissions in winter. The proportion is likely to be twice in summer due to the seasonal fluctuations of fossil fuel emissions. More importantly, the respiratory emissions could increase atmospheric CO2 concentration by about 2 ppm, accounting for 14% ± 6% of average CO2bio concentration in winter. This study highlights the importance of human respiration in carbon emissions in megacities and has implications for a better understanding of the regional carbon budget.
Clonal hematopoiesis–derived therapy-related myeloid neoplasms after autologous hematopoietic stem cell transplant for lymphoid and non-lymphoid disorders
Authors: Awada Hussein , Gurnari Carmelo , Visconte Valeria , Durmaz Arda , Kuzmanovic Teodora , Awada Hassan , Tu Zheng Jin , Cook James R. , Bolwell Brian J. , Sobecks Ronald , Kalaycio Matt , Bosler David , Maciejewski Jaroslaw P. 
Published: April 2024

AbstractTherapy-related myeloid neoplasms (tMN) are complications of cytotoxic therapies. Risk of tMN is high in recipients of autologous hematopoietic stem cell transplantation (aHSCT). Acquisition of genomic mutations represents a key pathogenic driver but the origins, timing and dynamics, particularly in the context of preexisting or emergent clonal hematopoiesis (CH), have not been sufficiently clarified. We studied a cohort of 1507 patients undergoing aHSCT and a cohort of 263 patients who developed tMN without aHSCT to determine clinico-molecular features unique to post-aHSCT tMN. We show that tMN occurs in up to 2.3% of patients at median of 2.6 years post-AHSCT. Age ≥ 60 years, male sex, radiotherapy, high treatment burden ( ≥ 3 lines of chemotherapy), and graft cellularity increased the risk of tMN. Time to evolution and overall survival were shorter in post-aHSCT tMN vs. other tMN, and the earlier group’s mutational pattern was enriched in PPM1D and TP53 lesions. Preexisting CH increased the risk of adverse outcomes including post-aHSCT tMN. Particularly, antecedent lesions affecting PPM1D and TP53 predicted tMN evolution post-transplant. Notably, CH-derived tMN had worse outcomes than non CH-derived tMN. As such, screening for CH before aHSCT may inform individual patients’ prognostic outcomes and influence their prospective treatment plans. Presented in part as an oral abstract at the 2022 American Society of Hematology Annual Meeting, New Orleans, LA, 2022.
Lithium rescues cultured rat metatarsals from dexamethasone-induced growth failure
Authors: Soucek Ondrej , Cinek Ondrej , Velentza Lilly , Semjonov Valerij , Bezdicka Martin , Zaman Farasat , Sävendahl Lars 
Published: April 2024

Abstract
Background
Glucocorticoids are commonly used in children with different chronic diseases. Growth failure represents a so far untreatable undesired side-effect. As lithium chloride (LiCl) is known to induce cell renewal in various tissues, we hypothesized that LiCl may prevent glucocorticoid-induced growth failure.

Methods
We monitored growth of fetal rat metatarsals cultured ex-vivo with dexamethasone and/or LiCl, while molecular mechanisms were explored through RNA sequencing by implementing the differential gene expression and gene set analysis. Quantification of β-catenin in human growth plate cartilage cultured with dexamethasone and/or LiCl was added for verification.

Results
After 14 days of culture, the length of dexamethasone-treated fetal rat metatarsals increased by 1.4 ± 0.2 mm compared to 2.4 ± 0.3 mm in control bones (p < 0.001). The combination of LiCl and dexamethasone led to bone length increase of 1.9 ± 0.3 mm (p < 0.001 vs. dexamethasone alone). By adding lithium, genes for cell cycle and Wnt/β-catenin, Hedgehog and Notch signaling, were upregulated compared to dexamethasone alone group.

Conclusions
LiCl has the potential to partially rescue from dexamethasone-induced bone growth impairment in an ex vivo model. Transcriptomics identified cell renewal and proliferation as candidates for the underlying mechanisms. Our observations may open up the development of a new treatment strategy for bone growth disorders.

Impact

LiCl is capable to prevent glucocorticoid-induced growth failure in rat metatarsals in vitro.

The accompanying drug-induced transcriptomic changes suggested cell renewal and proliferation as candidate underlying mechanisms.

Wnt/beta-catenin pathway could be one of those novel mechanisms.
Vitamin D opposes multilineage cell differentiation induced by Notch inhibition and BMP4 pathway activation in human colon organoids
Authors: Bustamante-Madrid Pilar , Barbáchano Antonio , Albandea-Rodríguez David , Rodríguez-Cobos Javier , Rodríguez-Salas Nuria , Prieto Isabel , Burgos Aurora , Martínez de Villarreal Jaime , Real Francisco X. , González-Sancho José Manuel , Larriba María Jesús , Lafarga Miguel , Muñoz Alberto , Fernández-Barral Asunción 
Published: April 2024

AbstractUnderstanding the mechanisms involved in colonic epithelial differentiation is key to unraveling the alterations causing inflammatory conditions and cancer. Organoid cultures provide an unique tool to address these questions but studies are scarce. We report a differentiation system toward enterocytes and goblet cells, the two major colonic epithelial cell lineages, using colon organoids generated from healthy tissue of colorectal cancer patients. Culture of these organoids in medium lacking stemness agents resulted in a modest ultrastructural differentiation phenotype with low-level expression of enterocyte (KLF4, KRT20, CA1, FABP2) and goblet cell (TFF2, TFF3, AGR2) lineage markers. BMP pathway activation through depletion of Noggin and addition of BMP4 resulted in enterocyte-biased differentiation. Contrarily, blockade of the Notch pathway using the γ-secretase inhibitor dibenzazepine (DBZ) favored goblet cell differentiation. Combination treatment with BMP4 and DBZ caused a balanced strong induction of both lineages. In contrast, colon tumor organoids responded poorly to BMP4 showing only weak signals of cell differentiation, and were unresponsive to DBZ. We also investigated the effects of 1α,25-dihydroxyvitamin D3 (calcitriol) on differentiation. Calcitriol attenuated the effects of BMP4 and DBZ on colon normal organoids, with reduced expression of differentiation genes and phenotype. Consistently, in normal organoids, calcitriol inhibited early signaling by BMP4 as assessed by reduction of the level of phospho-SMAD1/5/8. Our results show that BMP and Notch signaling play key roles in human colon stem cell differentiation to the enterocytic and goblet cell lineages and that calcitriol modulates these processes favoring stemness features.
METTL3-mediated deficiency of lncRNA HAR1A drives non-small cell lung cancer growth and metastasis by promoting ANXA2 stabilization
Authors: Ling Xiaodong , Qi Cuicui , Cao Kui , Lu Mengdi , Yang Yingnan , Zhang Jinfeng , Zhang Luquan , Zhu Jinhong , Ma Jianqun 
Published: April 2024

AbstractWe previously reported lncRNA HAR1A as a tumor suppressor in non-small cell lung cancer (NSCLC). However, the delicate working mechanisms of this lncRNA remain obscure. Herein, we demonstrated that the ectopic expression of HAR1A inhibited the proliferation, epithelial-mesenchymal transition (EMT), migration, and invasion of NSCLC cells and enhanced paclitaxel (PTX) sensitivity in vitro and in vivo. We identified the oncogenic protein annexin 2 (ANXA2) as a potential interacting patterner of HAR1A. HAR1A overexpression enhanced ANXA2 ubiquitination and accelerated its degradation via the ubiquitin–proteasome pathway. We further uncovered that HAR1A promoted the interaction between E3 ubiquitin ligase TRIM65 and ANXA2. Moreover, the ANXA2 plasmid transfection could reverse HAR1A overexpression-induced decreases in proliferation, migration, and invasion of NSCLC cells and the activity of the NF-κB signaling pathway. Finally, we found that HAR1A loss in NSCLC might be attributed to the upregulated METTL3. The m6A modification levels of HAR1A were increased in cancer cells, while YTHDF2 was responsible for recognizing m6A modification in the HAR1A, leading to the disintegration of this lncRNA. In conclusion, we found that METTL3-mediated m6A modification decreased HAR1A in NSCLC. HAR1A deficiency, in turn, stimulated tumor growth and metastasis by activating the ANXA2/p65 axis.
Identifying therapeutic targets for cancer among 2074 circulating proteins and risk of nine cancers
Authors: Smith-Byrne Karl , Hedman Åsa , Dimitriou Marios , Desai Trishna , Sokolov Alexandr V. , Schioth Helgi B. , Koprulu Mine , Pietzner Maik , Langenberg Claudia , Atkins Joshua , Penha Ricardo Cortez , McKay James , Brennan Paul , Zhou Sirui , Richards Brent J. , Yarmolinsky James , Martin Richard M. , Borlido Joana , Mu Xinmeng J. , Butterworth Adam , Shen Xia , Wilson Jim , Assimes Themistocles L. , Hung Rayjean J. , Amos Christopher , Purdue Mark , Rothman Nathaniel , Chanock Stephen , Travis Ruth C. , Johansson Mattias , Mälarstig Anders 
Published: April 2024

AbstractCirculating proteins can reveal key pathways to cancer and identify therapeutic targets for cancer prevention. We investigate 2,074 circulating proteins and risk of nine common cancers (bladder, breast, endometrium, head and neck, lung, ovary, pancreas, kidney, and malignant non-melanoma) using cis protein Mendelian randomisation and colocalization. We conduct additional analyses to identify adverse side-effects of altering risk proteins and map cancer risk proteins to drug targets. Here we find 40 proteins associated with common cancers, such as PLAUR and risk of breast cancer [odds ratio per standard deviation increment: 2.27, 1.88-2.74], and with high-mortality cancers, such as CTRB1 and pancreatic cancer [0.79, 0.73-0.85]. We also identify potential adverse effects of protein-altering interventions to reduce cancer risk, such as hypertension. Additionally, we report 18 proteins associated with cancer risk that map to existing drugs and 15 that are not currently under clinical investigation. In sum, we identify protein-cancer links that improve our understanding of cancer aetiology. We also demonstrate that the wider consequence of any protein-altering intervention on well-being and morbidity is required to interpret any utility of proteins as potential future targets for therapeutic prevention.