bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dedicated Automatic Recall Hepatocellular Cancer Surveillance Programme Demonstrates High Retention: A Population‐Based Cohort Study
Authors: Brahmania Mayur , Congly Stephen , Sachar Yashasavi , Burak Kelly W. , Lethebe Brendan , Szostakiwskyj Jessie Hart , Lautner David , Medellin Alexandra , Bhayana Deepak , Wong Jason , Nguyen Henry , Sadler Matthew D. , Borman Meredith , Aspinall Alexander I. , Coffin Carla S. , Swain Mark , Shaheen Abdel‐Aziz 
Published: February 2025

ABSTRACTIntroductionPatient, clinician, and system‐related barriers may affect adherence to hepatocellular carcinoma (HCC) surveillance programmes. The impact of a dedicated automated recall HCC surveillance programme on retention rates in patients eligible for screening is unknown. We aimed to describe and evaluate a large HCC surveillance programme in a publicly funded healthcare system.MethodsData were collected from January 1, 2013, to December 31, 2022, from a retrospective cohort of subjects enrolled in a publicly funded automated recall semi‐annual surveillance programme as per the American Association for the Study of Liver Disease HCC guidance in the Calgary Health Zone (~1.6 million), Canada. Patients were excluded if there was incomplete data or did not meet indications for surveillance. Cox regression was used to identify predictors of non‐retention to surveillance.ResultsA total of 7269 patients were included. The median was age 55.5 years (IQR: 45.5–63.8), 60% were male, 46% were of Asian descent, 51% had HBV infection, and 36% had cirrhosis (35% alcohol‐related). Median follow‐up was 4.9 years (IQR: 1.5–7.2). Overall, 52% (n = 3768) of patients were retained in the surveillance programme, while 8.3% (n = 603) left for potential medical reasons, and 40% (n = 2898) were lost in follow‐up. The median time in the programme for those lost in follow‐up was 0.81 years (IQR: 0.0–2.8) compared to 6.75 years if retained (IQR: 5.6–8.6; p < 0.001). In multivariable Cox regression analysis, HCV aetiology (HR 1.41; CI 1.23–1.62, p < 0.01), African ethnicity (HR 1.20, CI 1.02–1.42, p = 0.03), and cirrhosis (HR 1.16, CI 1.05–1.28, p < 0.01) increased risk of dropout. On interaction analysis, Hepatitis B amongst cirrhotic patients also increased risk of dropout (HR 1.48, CI 1.05–2.07, p = 0.02).ConclusionA dedicated automated recall HCC surveillance programme has a high retention rate in a large multi‐ethnic cohort of patients while identifying certain marginalised patient populations, such as those with viral liver disease, cirrhosis, or African ethnicity, as particularly vulnerable to loss to follow‐up.
Nonverbal Clause Constructions
Authors: Haspelmath Martin 
Published: February 2025

ABSTRACTThere are about a dozen well‐recognised types of nonverbal clause constructions, but the terminology by which these subtypes are known varies widely. This paper gives an overview of the major types and defines each term carefully, from the perspective of general syntax. For a number of well‐established concepts that have no corresponding well‐established term, I propose novel terms. There are four major predicational types (classificational, attributional, predlocative and appertentive), and four major nonpredicational types (equational, existential, predpossessive and hyparctic).
Predictors of Anaemia Among Young Children Receiving Daily Micronutrient Powders (MNPs) for 24 Weeks in Bangladesh: A Secondary Analysis of the Zinc in Powders Trial
Authors: Thompson Lauren , Arnold Charles , Peerson Janet , Long Julie M. , Westcott Jamie L. E. , Islam M. Munirul , Black Robert E. , Krebs Nancy F. , McDonald Christine M. 
Published: February 2025

ABSTRACTIn Bangladesh, anaemia is estimated to affect 52% of children 6–59 months, with the youngest children (6–23 months) experiencing the highest levels of anaemia (71%). Micronutrient powders (MNPs) are designed to increase micronutrient intake in young children; however, in some settings, the prevalence of anaemia may remain elevated despite the high coverage of MNPs. In a secondary analysis of the Zinc in Powders trial (ZiPT), we identified risk factors that were associated with anaemia among Bangladeshi children 9–11 months of age who received standard 15‐component MNPs, including 10 mg of iron, daily for 24 weeks. At enrolment, socio‐demographic characteristics were collected. Morbidity symptoms were assessed on a semi‐weekly basis. Haemoglobin (measured via single‐drop capillary blood using Hemocue 301+) and child anthropometry were assessed at enrolment and endline (24 weeks). Risk factors for anaemia at endline (24 weeks) were identified using minimally adjusted (age and sex) logistic regression models. Multivariate models were subsequently constructed, controlling for age, sex and significant risk factors. Of the 481 children randomized to the MNP arm, 442 completed the trial and had haemoglobin data available at endline. Anaemia (haemoglobin < 10.5 g/dL) prevalence declined from 54.1% at baseline to 32.6% at endline. In minimally adjusted models, season of enrolment, underweight at enrolment, asset score, hygiene score and frequent morbidity symptoms were associated with the odds of anaemia at endline. However, some factors lost statistical significance in multivariate models. MNPs are an important tool for anaemia prevention; however, they should be part of an integrated approach for anaemia control.
Systematic Review and Meta‐Analysis: Examining the Psychometric Evaluations of Disordered Eating Scales in Adults Living With Gastrointestinal Conditions
Authors: Soliman Olivia Marie , Mikocka‐Walus Antonina , Warner Molly M. , Skvarc David , Olive Lisa , Knowles Simon R. 
Published: February 2025

ABSTRACTBackgroundThe scales used to assess disordered eating are often not validated in adults living with gastrointestinal conditions (i.e., gastrointestinal populations). This systematic review and meta‐analysis aimed to examine the psychometric evaluations (i.e., assessments of reliability and validity) of disordered eating scales in adult gastrointestinal populations and quantify the prevalence of disordered eating in both gastrointestinal and non‐gastrointestinal populations.MethodsWe conducted a search of observational studies up to May 2024 that measured disordered eating using a scale in adults with a gastrointestinal condition. Psychometric evaluations of the scales were narratively reviewed. Prevalence rates of disordered eating were pooled using a random‐effects meta‐analysis, and risk of bias was assessed using an adapted Newcastle Ottawa Scale.Key ResultsAmong 29 studies (overall medium risk of bias), 23 reported prevalences of disordered eating in gastrointestinal populations, and eight of these studies also reported prevalences in non‐gastrointestinal populations. Only one out of 10 scales was developed and psychometrically evaluated in gastrointestinal populations, and 11 studies reported internal consistency (range α = 0.63 to α = 0.95). The prevalence of disordered eating was 33.2% (p < 0.001; 95% confidence interval: 0.25–0.41; I2 = 97.34%) in gastrointestinal populations and 21.0% (p < 0.001; 95% confidence interval: 0.09–0.32; I2 = 97.41%) in non‐gastrointestinal populations. Subgroup analyses showed consistently high heterogeneity.Conclusions and InferencesThe utilisation of current disordered eating scales for adults living with gastrointestinal conditions should be undertaken with caution, and there is a need for disordered eating scales to be developed and validated in this population.
Nutrient resorption of leaves and roots coordinates with root nutrient‐acquisition strategies in a temperate forest
Authors: Wang Dongnan , Freschet Grégoire T. , McCormack M. Luke , Lambers Hans , Gu Jiacun 
Published: February 2025

Summary
Nutrient acquisition, conservation and recycling are three mechanisms for plants to meet their nutritional requirements. However, how nutrient recycling relates to other mechanisms remains unknown. Here, we hypothesize that nutrient resorption processes are coordinated with plant nutrient‐acquisition strategies.
We measured leaf and root nutrient resorption efficiencies and proficiencies and root economic traits for 34 coexisting ectomycorrhizal (ECM) and arbuscular mycorrhizal (AM) temperate woody species.
Our results revealed that species with lower foraging efficiency relying on mycorrhizal fungi for nutrient absorption (e.g. larger root diameter) have higher root phosphorus resorption efficiency and greater phosphorus concentrations of senesced roots, while species with conservative nutrient‐acquisition strategies (e.g. higher root tissue density) have lower nitrogen and phosphorus concentrations of senesced leaves and roots.
Overall, our results demonstrate that plant nutrient acquisition and protection strategies are partly coordinated with plants' ability to resorb nutrients. First, they suggest that outsourcing phosphorus acquisition to mycorrhiza may limit the value for plants to reduce phosphorus loss. Second, those species better able to protect their living leaves and roots from adversity are not necessarily the most efficient to recycle nutrients, but are nonetheless the most capable of minimizing nutrient loss during organ senescence.
Caregiver‐Reported Motivation and Access to Mental Health Services for Pediatric Atopic Dermatitis Patients: A Cross‐Sectional Study
Authors: Chau Courtney A. , Loiselle Allison R. , Johnson Jessica K. , Begolka Wendy Smith 
Published: February 2025

ABSTRACTAtopic dermatitis (AD) is associated with several comorbidities, including mental health (MH) conditions among children. We conducted a survey study of caregivers of pediatric AD patients (aged 8–17) (n = 163) and collected information about their child's MH symptoms and their experience seeking MH services for their child. Nearly half of caregivers reported their child had 6 or more days of poor MH symptoms in the past month and reported that barriers to accessing MH services were MH provider inaccessibility (27.0%), distance and transportation (23.3%), and insurance obstacles (19.0%). Given the substantial burden of AD on pediatric patients and the accessibility barriers elucidated in this survey study, engagement of both eczema and MH providers is essential to recognize MH burden among patients and overcome access barriers.
Racial Differences in Disease Characteristics of Pediatric Hidradenitis Suppurativa
Authors: Onamusi Toluwalashe , Murphy Jennifer , Shah Sonal D. 
Published: February 2025

ABSTRACTUnderstanding the potential racial differences in presentation, severity, and outcomes of pediatric hidradenitis suppurativa (HS) can help deliver equitable and individualized care, especially as this condition is increasingly being acknowledged in this population. We conducted a single‐center retrospective analysis of 70 pediatric patients diagnosed with HS who were seen at our institution. There was no statistically significant difference in biologic treatments between non‐Hispanic Black (NHB) patients when compared to non‐Hispanic White (NHW) patients, although NHW patients overall received biologic therapy more frequently (17.4%) than NHB patients (12.8%). The observed racial differences in pediatric HS highlight the need for further investigation of possible underlying factors contributing to disease heterogeneity and treatment response to optimize the care provided and patient outcomes.
Evaluating Activated Regulatory T Cells as a Biomarker of Chronic Allograft Inflammation in Pediatric Kidney Transplant Recipients
Authors: Leung Macyn L. , Barrett‐Chan Ella , Levings Megan K. , Vercauteren Suzanne , Blydt‐Hansen Tom D. 
Published: February 2025

ABSTRACTBackgroundThere is a need for noninvasive immunological biomarkers that can identify stable kidney allograft immune quiescence to inform individualized immunosuppression.MethodsWe conducted a cross‐sectional, pilot cohort study evaluating the relative abundance of regulatory T cells (Tregs) to effector T‐cell (Teff) populations as a surrogate marker of long‐term graft tolerance. We obtained fresh peripheral blood mononuclear cell samples from stable pediatric kidney transplant recipients, most with recent surveillance biopsies to identify the presence or absence of chronic inflammation. Tregs were sub‐phenotyped as naïve, memory, and activated Tregs (aTreg). Treg/Teff ratios were modeled for association with chronic inflammation and in the context of potential clinical features.ResultsTwenty‐seven patient samples were included on standard immunosuppression (tacrolimus, mycophenolate, and prednisone) with a mean age of 9.2 ± 5.0 years, at 30.2 ± 21.7 months posttransplant. The ratio of aTreg (FOXP3++CD45RA−) to Th17 cells (CD4+IL‐17+) was significantly greater in patients without inflammation than in patients with graft inflammation (p < 0.01). Similarly, there was a trend toward greater aTreg/CD4+ T cells and aTreg/CD8+ Teff in patients without inflammation (p = 0.05 and 0.09, respectively). There was no significant association for inflammation with naïve or memory Treg/Teff ratios. Multiple logistic regression with all three aTreg/Teff ratios modeled allograft inflammation with high sensitivity and specificity (AUC = 0.83, 95% CI 0.67–0.98).ConclusionsThe proportion of peripheral blood aTregs/Teff cells in this pilot cohort of stable pediatric kidney transplant recipients was associated with immune quiescence. These data support further investigation into aTreg/Teff monitoring to inform precision immunosuppressive treatment.
Impact of Pharmacogenomic Testing in Pediatric Heart and Kidney Transplant
Authors: Jackson Rachel L. , Heyrend Caroline , Bucher Bridget , Brewer Ashlie , Peterson Caitlin , May Lindsay J. , Bonkowsky Joshua L. 
Published: February 2025

ABSTRACTBackgroundPediatric solid organ transplantation is a complex process including a tightly orchestrated medication regimen, essential for prevention of infection, rejection, graft failure, and mortality. Pharmacogenomic (PGx) testing tailors medication therapy to the individual patient, focusing on safety, efficacy, and avoidance of adverse effects. Implementation of PGx panel results into clinical practice for pediatric transplant patients has not been evaluated.MethodsPediatric patients evaluated for heart, kidney, or combined heart‐kidney transplant at a tertiary children's hospital from October 2021 to October 2023 received PGx panel testing. Primary outcome measure: Report the prevalence of actionable PGx variants for key genes impacting pharmacotherapy in pre‐ and post–heart and kidney transplant populations.ResultsA total of 73 patients were included, predominately white (84.9%) and male (64.4%), with a mean age of 8.8 ± 6.4 years. Indications for PGx testing included evaluation for heart transplant (38.4%), kidney transplant (38.4%), combined heart–kidney transplant (4.1%), or to inform posttransplant care (19.2%). All patients had at least one actionable phenotype identified. 37 of 73 patients (50.7%) had at least one actionable phenotype for the transplant‐specific genes captured including CYP3A5, SLCO1B1, G6PD, TPMT, prothrombin (Factor 2), and Factor V Leiden. 16 of 73 patients (21.9%) had actionable CYP3A5 phenotypes. 15 of 73 (20.5%) had actionable SLCO1B1 phenotypes. 9 of 73 patients (12.3%) had actionable TPMT phenotypes. 5 of 73 (6.8%) had Prothrombin or Factor V Leiden variants.ConclusionsRoutine pretransplant PGx testing provided information that was actionable and could be utilized to optimize posttransplant medications for all patients.
Omic characterisation of multi‐component defences against the necrotrophic pathogen Pyrenophora tritici‐repentis in wheat
Authors: Ferreira L. C. , Santana F. M. , Scagliusi S. M. M. , Beckmann M. , Mur L. A. J. 
Published: February 2025

Abstract
Tan Spot disease is caused by the necrotrophic pathogen Pyrenophora tritici‐repentis (Ptr) and poses a significant threat to global wheat production. Therefore, novel sources of resistance need to be identified, coupled with a fuller mechanistic understanding of host responses to Ptr.
Herein, we characterise the interaction between a ToxA‐positive Ptr strain and parental wheat lines from a multiparent advanced generation intercross (MAGIC) population.
Genotypes displaying moderate resistance (‘Robigus’) or susceptibility (‘Hereward’) to Ptr challenge were identified and characterised through histological, metabolomic, and transcriptomic approaches. Histological investigations indicated the prominence of papilla‐based defences in Robigus. Transcriptomic analyses could link this to the expression of barrier‐related genes i.e. actin polymerisation, callose deposition, vesicle trafficking, and cellulose synthesis. Inhibiting actin polymerisation with cytochalasin E increased lesion numbers but did not augment lesion growth, suggesting the deployment of other defence mechanisms. These may be influenced by auxin, as its exogenous application exacerbated symptom development. Transcriptomic and metabolomic analyses in Hereward following challenge with Ptr suggested shifts in primary metabolism, affecting glycolysis, the TCA cycle, and the γ‐aminobutyric acid (GABA) shunt. Activation of salicylic acid (SA)‐associated genes, including NPR1 and WRKY33, was specific to Hereward, and exogenous SA increased susceptibility to Ptr in both genotypes.
This study suggests barrier defences could be effective against Ptr as well as a lack of susceptibility factors like SA or the appropriate processing of IAA. These findings offer potential avenues for enhancing wheat resistance to Ptr.
Narrative Transportation and the Persuasive Power of the Film Don't Look Up
Authors: Merry Melissa K. , Payne Rodger A. 
Published: February 2025

ABSTRACTThis study examines the impact of fiction and film on climate change beliefs. Using data from a nationally representative survey of 2045 individuals conducted in April–May 2022, we examine whether individuals who watched the satirical film Don't Look Up, which debuted on Netflix in December 2021, demonstrated greater climate change concern, motivation to act, and policy support than those who did not see the film. We also examine the impact of narrative transportation on persuasion, assessing whether being deeply immersed in the film predicted climate change attitudes. Our results indicate that viewers who were deeply engaged with the film held stronger proenvironmental attitudes. These associations occurred among both Democratic and Republican viewers, suggesting that transportation induced by entertainment media can shape public opinion on policy issues. Our results have implications for the micro and macro levels of the Narrative Policy Framework and for climate change communication, more generally.Related ArticlesChalaya, T., C. Schlaufer, and A. Uldanov. 2024. “You Are a Hero! The Influence of Audience‐as‐hero Narratives on Policy Support.” Politics & Policy 52, no. 3: 479–499. https://doi.org/10.1111/polp.12609.Merry, M. K. 2022. “Trump's Tweets as Policy Narratives: Constructing the Immigration Issue via Social Media.” Politics & Policy 50, no. 4: 752–772. https://doi.org/10.1111/polp.12487.Shanahan, E. A., M. K. McBeth, and P. L. Hathaway. 2011. “Narrative Policy Framework: The Influence of Media Policy Narrative on Public Opinion.” Politics & Policy 39, no. 3: 373–400. https://doi.org/10.1111/j.1747‐1346.2011.00295.x.
Quick and Effective Evaluation Methods for Biocontrol Agents and Biostimulants Against Phytopathogenic Fungi Relevant for Various Cropping Systems
Authors: Pérez‐Pizá María Cecilia , Sautua Francisco José , Kocira Sławomir , Bohatá Andrea , Bedrníček Jan , Sozoniuk Magdalena , Carmona Marcelo Aníbal 
Published: February 2025

ABSTRACTFungal diseases pose a significant threat to global agriculture, leading to major crop losses and harmful mycotoxin contamination. Effective management of these diseases is crucial for safeguarding crop production and ensuring food safety. With a growing emphasis on sustainability, there is increased interest in using biological control agents (BCAs) and biostimulants with protective effects (BPEs). This paper provides a comprehensive set of methods or protocols for rapidly screening the protective potential of BCAs and BPEs, covering assessments from pathogen‐only evaluations to those involving both the pathogen and the host at early stages. By promoting standardised and reproducible methods, this review offers a concise guide for initial evaluations, helping to identify promising microorganisms and substances for further research. These methods allow for comparisons between BCAs/BPEs and conventional chemical treatments, the assessment of potential synergies, the ability to control fungicide‐resistant strains and the evaluation of phytotoxicity. The goal is to improve the understanding and integration of BCAs and BPEs into agricultural practices, reducing reliance on agrochemicals and promoting sustainable management of fungal diseases. Future research should expand the range of biostimulants under investigation and refine evaluation methods to maximise their effectiveness in real‐world applications.
Fusarium oxysporum f. sp. elaeidis and Its Biosecurity Threat to Oil Palm‐Producing Countries
Authors: Adusei‐Fosu Kwasi , Flood Julie , Rusli Mohd Hefni , Agyepong Victoria , Osei‐Wusu Mavis , Corbett Dale , Bhatia Nitin 
Published: February 2025

ABSTRACTThe most damaging disease of oil palm is Fusarium wilt caused by a soilborne fungal pathogen, Fusarium oxysporum f. sp. elaeidis (Foe). The disease is endemic to Africa and affects oil palm production there. Limited Fusarium wilt outbreaks have occurred in South America, but the disease has not yet been reported in South‐East Asia. An earlier review of Foe in 2006 provided updates on symptoms, spread and the difficulty in managing the disease. This paper updates our knowledge of oil palm, socio‐economic and environmental impacts of cultivation, Fusarium wilt disease epidemiology, Foe detection techniques, disease management strategies and biosecurity perspectives. Breeding for tolerant plant materials has significantly advanced in Africa, but financial constraints in several countries have limited the production of tolerant oil palm seed materials. Other emerging technologies for Foe control are also presented here, acknowledging the specific challenges to help inform the oil palm industry. We highlight the need to strengthen biosecurity plans in disease‐free regions. In these countries/regions that are currently free from the pathogen but cultivating susceptible plant materials, biosecurity protocols are essential to reduce threat of disease introduction and spread. Climatic change is another challenge for oil palm‐producing countries, both those currently free from the disease and those where Foe is endemic, and should be taken into consideration when planning and implementing biosecurity measures.