bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sociodemographic Correlates of Behavioral Problems Among Rural Chinese Schoolchildren
Authors: Feng Hui , Liu Jianghong , Wang Ying , He Guoping 
Published: January 2011

ABSTRACT
Objective: To investigate the problem behaviors of children from grades 4–6 and associated factors in the rural Hunan province of China.Design and Sample: Randomized cluster sampling in 3 rural areas of the Hunan province was used. 435 subjects were randomly selected from grades 4–6.Measures: A researcher‐designed questionnaire was used to find influential demographic, parental, and socioeconomic factors. The prediction test of problem children (PPCT) was used to assess problem behaviors.Results: The prevalence of the early child problem behaviors in our sample was 17.44%. Associated factors include gender, willingness to attend school, parents' expectations of the children's educational degree, parents working outside the home (left‐behind children), and children's feeling of their parents' understanding of them.Conclusions: The prevalence of children with problem behaviors was higher in rural areas in Hunan than in China as a whole. This may be partly explained by the fact that parents must often work in the cities and leave their children behind at home, increasing the chances that those children develop behavioral problems. This phenomenon also applies in other developing countries, making it a public health concern. Therefore, there is a need to prevent problem behaviors through collaboration among families, schools, and society.
Cervicomedullary Junction Spinal Cord Stimulation for Head and Facial Pain
Authors: Tomycz Nestor D. , Deibert Christopher P. , Moossy John J. 
Published: January 2011

Objective.— To review our experience with cervicomedullary junction spinal cord stimulation (SCS), to alleviate head and facial pain.Background.— There is a dearth of literature regarding the use of spinal cord stimulation for treating head and facial pain.Design.— We performed a Boolean search of the electronic medical record (1990‐2009) and identified 35 patients (9 men, 26 women) for whom the senior author (J.J.M) trialed paddle lead cervicomedullary junction stimulation (CMJ‐S) for intractable head or facial pain. Twenty‐five patients (71.4%) had a successful trial with subsequent implantation of SCS hardware and 10 patients (28.6%) experienced a failed trial. Pain syndromes were categorized into diagnostic groups: trigeminal deafferentation pain (TDP), trigeminal neuropathic pain (TNP), occipital pain/neuralgia, post‐herpetic neuralgia (PHN), and post‐stroke facial pain. Follow‐up via structured telephone interview was obtained in 25 patients (71.4%).Results.— Among the 25 patients available for follow‐up, 16 patients (64%) underwent implantation and 9 patients (36%) had a failed trial of CMJ‐S. The mean patient age and length of follow‐up was 47.3 years old (20‐78 years old) and 53.4 months (2‐120 months), respectively. On a 0‐10 pain intensity scale (0 being no pain and 10 being the worst degree of pain), a mean pretrial pain level of 9.6 (range 7‐10) had been reduced to a mean of 4.8 (0‐10) at follow‐up. Successful trial and subsequent implantation occurred in 7 patients with TDP (70%), 4 patients with TNP (80%), both patients with PHN (100%), and in the single patient with post‐stroke facial pain (100%) but in only 2 patients (28.6%) with occipital neuralgia/pain. At the time of telephone interview, 4 of the implanted patents (25%) had their hardware removed because of loss of effectiveness (3) and infection (1). The other 12 implanted patients (75%) continue to use CMJ‐S on a daily basis and insist that it has improved their quality of life. Six current users (50%) of CMJ‐S have been able to decrease their use of oral pain medications. Complications in the implanted group included infection (1), uncomfortable paresthesias from breakdown of connecting wire insulation (1), and gradual loss of effectiveness (3).Conclusions.— Our preliminary experience suggests that patients suffering from TDP, TNP, and PHN may respond favorably to CMJ‐S whereas patients with occipital neuralgia/pain are rarely palliated by this neuromodulatory approach.
Body Mass Index and Adult Weight Gain Among Reproductive Age Women With Migraine
Authors: Vo Michelle , Ainalem Abinnet , Qiu Chunfang , Peterlin B. Lee , Aurora Sheena K. , Williams Michelle A. 
Published: January 2011

(Headache 2011;51:559‐569)Objective.— To evaluate the cross‐sectional relationship between migraine and pregravid obesity; and to assess the risk of adult weight gain among women with history of a pediatric diagnosis of migraine.Background.— Obesity, comorbid with pain disorders including migraine, shares common pathophysiological characteristics including systemic inflammation, and derangements in adipose‐tissue derived cytokines. Despite biochemical and epidemiological commonalities, obesity–migraine associations have been inconsistently observed.Methods.— A cohort of 3733 women was interviewed during early pregnancy. We ascertained participants' self‐reported history of physician‐diagnosed migraine and collected self‐reported information about pregravid weight, adult height, and net weight change from age 18 to the 3‐months period before pregnancy. Using pregravid body mass index, we categorized participants as follows: lean (<18.5 kg/m2), normal (18.5‐24.9 kg/m2), overweight (25‐29.9 kg/m2), obese (30‐34.9 kg/m2), severely obese (35‐39.9 kg/m2), and morbidly obese (≥40 kg/m2). Logistic regression procedures were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).Results.— After adjusting for confounders, relative to normal weight women, obese women had a 1.48‐fold increased odds of migraine (OR = 1.48; 95% CI 1.12‐1.96). Severely obese (OR = 2.07; 95% CI 1.27‐3.39) and morbidly obese (OR = 2.75; 95% CI 1.60‐4.70) had the highest odds of migraines. Women with a history of diagnosed pediatric migraine had a 1.67‐fold higher odds of gaining ≥10.0 kg above their weight at age 18, as compared with non‐migraineurs (OR = 1.67; 95% CI 1.13‐2.47).Conclusion.— These data support earlier observations of migraine–obesity association among women, and extend the literature to include evidence of adult weight gain among women with a history of pediatric migraine.
Absence seizures in the first 3 years of life: An electroclinical study of 46 cases
Authors: Horacio Caraballo Roberto , Darra Francesca , Fontana Elena , Garcia Roberto , Monese Eduardo , Dalla Bernardina Bernardo 
Published: January 2011

SummaryPurpose: Early onset absence seizures have been considered a rare heterogeneous group with a poor prognosis. Only few patients may be categorized into well‐known syndromes. We have evaluated electroclinical features, evolution, and the nosologic boundaries of early onset absence seizures.Methods: Forty‐six neurologically normal patients with absence seizures associated with bilateral, synchronic, or asynchronic, and symmetric or asymmetric spike‐and‐wave paroxysms with onset in the first 3 years of life were included. Patients with abnormal neurologic examination and brain imaging were excluded from the study.Key Findings: In our study, 39 patients met the clinical and electroencephalography (EEG) criteria of well‐defined epileptic syndromes. Childhood absence epilepsy was found in 11 patients, benign myoclonic epilepsy in infancy in 18 patients, eyelid myoclonic epilepsy in 4, and epilepsy with myoclonic absences in 6. We did not find clinical and EEG criteria of well‐recognized epileptic syndromes in seven children. Nine of 11 patients with simple absence seizures became seizure free. All these patients had normal neurologic and neuropsychological evaluations. Of the 35 patients who had absence seizures associated with myoclonic seizures, 20 became seizure free. Fifteen of 35 children continue having seizures. At the last visit, 20 of these 35 patients had normal neurologic and neuropsychological evaluations, 11 presented with mild mental retardation, and 4 with severe mental retardation.Significance: Epilepsies with absence seizures of early onset are relatively uncommon. Most of the patients had well‐defined epileptic syndromes with a variable evolution. The evolution depended on the epileptic syndromes.
Population pharmacokinetics of pregabalin in healthy subjects and patients with chronic pain or partial seizures
Authors: Bockbrader Howard N. , Burger Paula , Knapp Lloyd , Corrigan Brian W. 
Published: January 2011

SummaryPurpose:  Pregabalin, a high‐affinity ligand for α2δ subunits of voltage‐gated calcium channels, is a novel pharmacotherapy for chronic pain, partial seizures, and other disorders. The present study investigated the population pharmacokinetics of pregabalin following single and multiple doses in healthy volunteers and patient populations.Methods:  Using nonlinear mixed‐effect modeling, 5,583 plasma pregabalin concentration–time samples from 1,723 subjects were analyzed: 2,868 samples from healthy volunteers or subjects with renal impairment (n = 123), 1,513 from patients with partial seizures (n = 626), and 1,202 from patients with chronic pain (n = 974). A one‐compartment model with first‐order elimination and absorption processes and absorption lag time was used.Key Findings:  This pharmacostatistical model showed that: (1) pregabalin oral clearance (CL/F) was directly proportional to creatinine clearance (CLcr), but was independent of gender, race, age, female hormonal status, daily dose, and dosing regimen; (2) apparent volume of distribution was dependent on body weight and gender; (3) absorption rate was decreased when given with food; and (4) coadministration with marketed antiepileptic drugs (AEDs) had no significant effect on pregabalin CL/F.Significance:  Pregabalin CL/F is related to CLcr, and this relationship is similar among healthy volunteers and patients with either partial seizures or chronic pain disorders. The only factor having a clinically significant influence on steady‐state plasma pregabalin concentrations is renal function.
The nature and extent of cerebellar atrophy in chronic temporal lobe epilepsy
Authors: Oyegbile Temitayo O. , Bayless Katherine , Dabbs Kevin , Jones Jana , Rutecki Paul , Pierson Ronald , Seidenberg Michael , Hermann Bruce 
Published: January 2011

SummaryPurpose:  Research indicates that patients with chronic temporal lobe epilepsy (TLE) exhibit cerebellar atrophy compared to healthy controls, but the degree to which specific regions of the cerebellum are affected remains unclear. The purpose of this study was to characterize the extent and lateralization of atrophy in individual cerebellar lobes and subregions in unilateral TLE using advanced quantitative magnetic resonance imaging (MRI) techniques.Methods:  Study participants were 46 persons with TLE and 31 age‐ and gender‐ matched healthy controls. All participants underwent high‐resolution MRI with manual tracing of the cerebellum yielding gray and white matter volumes of the right and left anterior lobes, superior posterior lobes, inferior posterior lobes, and corpus medullare. The degree to which asymmetric versus generalized abnormalities was evident in unilateral chronic TLE was determined and related to selected clinical seizure features (age of onset, duration of disorder).Key Findings:  There were no lateralized abnormalities in cerebellar gray matter or white matter in patients with right or left TLE (all p’s > 0.2). Compared with controls, unilateral TLE was associated with significant bilateral reductions in the superior (p = 0.032) and inferior (p = 0.023) posterior lobes, whereas volume was significantly increased in the anterior lobes (p = 0.002), especially in patients with early onset TLE, and not significantly different in the corpus medullare (p = 0.71). Total superior cerebellar tissue volumes were reduced in association with increasing duration of epilepsy.Significance:  Patients with unilateral TLE exhibit a pattern of bilateral cerebellar pathology characterized by atrophy of the superior and inferior posterior lobes, hypertrophy of the anterior lobe, and no effect on the corpus medullare. Cross‐sectional analyses show that specific aspects of cerebellar pathology are associated with neurodevelopmental (anterior lobe) or chronicity‐related (superior posterior lobe) features of the disorder.
Hyponatremia and risk of seizures: A retrospective cross‐sectional study
Authors: Halawa Imad , Andersson Tomas , Tomson Torbjörn 
Published: January 2011

SummaryThis retrospective cross‐sectional study was carried out to study the association between different levels of hyponatremia and the occurrence of epileptic seizures in patients without a prior epilepsy diagnosis. We identified from the hospital database, 363 inpatients of a Swedish County hospital who between March 2003 and August 2006 were found to have serum sodium levels <125 mm. Medical records were reviewed and we identified 11 patients with seizures in conjunction with their hyponatremia. Seizures were the only neurologic manifestation of hyponatremia in patients with serum sodium levels >115 mm. Of 150 patients reviewed with serum sodium levels of 120–124 mm, one had a seizure. Using 120–124 mm as reference, odds ratios (95% confidence interval) for having seizures at serum sodium levels of 115–119 mm was 3.85 (0.40–37.53), 8.43 (0.859–82.85) at 110–114 mm, and 18.06 (1.96–166.86) at <110 mm.
Efficacy and tolerability of the Modified Atkins Diet in adults with pharmacoresistant epilepsy: A prospective observational study
Authors: Smith Mara , Politzer Nina , MacGarvie Debra , McAndrews Mary‐Pat , del Campo Martin 
Published: January 2011

SummaryPurpose:  Evidence from the pediatric population exists for the efficacy of ketogenic diets in reducing seizure frequency in patients with intractable epilepsy. Recent evidence suggests that a Modified Atkins Diet may be a beneficial form of cotherapy for adult patients with pharmacoresistant epilepsy.Methods:  A prospective, open‐label study was performed of adults >18 years of age with pharmacoresistant epilepsy. Carbohydrates were restricted to 20 g/day. Fluids and calories from protein and fat were allowed ad libitum.Key Findings:  Eighteen patients, ages 18–55 years, were initially enrolled. Using an intent‐to‐treat analysis, 12% had a >50% seizure reduction after 3 months; 28% after 6 months, and 21% after 12 months. Response at 3 months predicted response at 12 months in 79% of patients. The mean decrease in weight was 10.9 kg and the mean decrease in body mass index (BMI) was 3.8, p = 0.01. Fourteen of 18 patients (78%) completed 12 months of this diet. Patients experienced a decrease in triglycerides from (mean) 1.22 to 0.9 mm (p = 0.02).Significance:  The Modified Atkins Diet demonstrates modest efficacy as cotherapy for some adults with pharmacoresistant epilepsy and may be also helpful for weight loss. Financial and logistical barriers were significant factors for those who declined enrollment and for those who discontinued the study.
The Arabidopsis protein kinase Pto‐interacting 1‐4 is a common target of the oxidative signal‐inducible 1 and mitogen‐activated protein kinases
Authors: Forzani Celine , Carreri Alessandro , de la Fuente van Bentem Sergio , Lecourieux David , Lecourieux Fatma , Hirt Heribert 
Published: January 2011

In Arabidopsis thaliana, the serine/threonine protein kinase oxidative signal‐inducible 1 (OXI1), mediates oxidative stress signalling. Its activity is required for full activation of the mitogen‐activated protein kinases (MAPKs), MPK3 and MPK6, in response to oxidative stress. In addition, the serine/threonine protein kinase Pto‐interacting 1‐2 (PTI1‐2) has been positioned downstream from OXI1, but whether PTI1‐2 signals through MAPK cascades is unclear. Using a yeast two‐hybrid screen we show that OXI1 also interacts with PTI1‐4. OXI1 and PTI1‐4 are stress‐responsive genes and are expressed in the same tissues. Therefore, studies were undertaken to determine whether PTI1‐4 is positioned in the OXI1/MAPK signalling pathway. The interaction between OXI1 and PTI1‐4 was confirmed by using in vivo co‐immunoprecipitation experiments. OXI1 and PTI1‐4 were substrates of MPK3 and MPK6 in vitro. Although no direct interaction was detected between OXI1 and MPK3 or MPK6, in vitro binding studies showed interactions between MPK3 or MPK6 with PTI1‐4. In addition, PTI1‐4 and MPK6 were found in vivo in the same protein complex. These results demonstrate that PTI1‐4 signals via OXI1 and MPK6 signalling cascades.Structured digital abstract
PTI1‐4 and OXI1 phosphorylate by protein kinase assay (View interaction)
OXI1 physically interacts with PTI1‐4 by two hybrid (View interaction)
MPK6 physically interacts with PTI1‐4 by anti tag coimmunoprecipitation (View interaction)
MPK3 and OXI1 phosphorylate by protein kinase assay (View interaction)
MPK6 binds to PTI1‐4 by pull down (View interaction)
PTI1‐4 and MPK3 phosphorylate by protein kinase assay (View interaction)
OXI1 phosphorylates OXI1 by protein kinase assay (View interaction)
OXI1 physically interacts with PTI1‐4 by anti tag coimmunoprecipitation (View interaction)
PTI1‐4 and MPK6 phosphorylate by protein kinase assay (View interaction)
PTI1‐4 physically interacts with AGC2‐3 by two hybrid (View interaction)
OXI1 binds to PTI1‐4 by pulldown (Viewinteraction)
MPK6 and OXI1 phosphorylates by protein kinase assay (View interaction)
MPK3 binds to PTI1‐4 by pull down (View interaction)
PTI1‐4 physically interacts with AGC2‐2 by two hybrid (View interaction)
OXI1 physically interacts with PTI1‐1 by two hybrid (View interaction)
PTI1‐4 binds to OXI1 by pull down (View interaction)
What Is the Definition of a Satisfactory Erectile Function After Bilateral Nerve Sparing Radical Prostatectomy?
Authors: Briganti Alberto , Gallina Andrea , Suardi Nazareno , Capitanio Umberto , Tutolo Manuela , Bianchi Marco , Salonia Andrea , Colombo Renzo , Di Girolamo Valerio , Martinez-Salamanca Juan Ignazio , Guazzoni Giorgio , Rigatti Patrizio , Montorsi Francesco 
Published: January 2011

ABSTRACT

Introduction
Different cut-offs of the erectile function (EF) domain of the International Index of Erectile Function (IIEF) have been used as definition of postoperative EF recovery.

Aim
To test the correlation between patient satisfaction and IIEF-EF domain score cut-offs.

Main Outcome Measure
The IIEF was used to evaluate EF and satisfaction before and after bilateral nerve sparing radical prostatectomy (BNSRP).

Methods
The study included 165 consecutive patients treated with retropubic BNSRP at a single institution. All patients had normal preoperative EF (IIEF-EF ≥ 26) and reached an IIEF-EF ≥ 17 following surgery. Complete data included EF, intercourse (IS), and overall satisfaction (OS) assessed by the corresponding domains of the IIEF administered prior and after surgery. Patients were divided into three groups according to the highest IIEF-EF score reached postoperatively, namely 17–21 (group 1), 22–25 (group 2), and ≥26 (group 3). One-way analysis of variance was used to compare IIEF-OS and IIEF-IS domain scores at the time the EF end point was reached. The same analyses were repeated separately in those patients with a complete EF recovery after surgery (group 3).

Results
Mean preoperative IIEF-OS and IIEF-IS domain score was 8.4, 8.8, 8.7 and 11.6, 11.8, 11.9 in group 1, 2, 3, respectively (all P ≥ 0.3). After a mean follow-up of 26.7 months, mean postoperative IIEF-OS and IIEF-IS domain scores assessed at the time of EF recovery were comparable for patients reaching an IIEF-EF of 22–25 and for patients scoring postoperatively ≥26 (8.1, 8.1, and 10.6, 11.4; all P ≥ 0.3). However, mean IIEF-OS and IIEF-IS domain scores of these patients were significantly higher as compared to patients reaching an IIEF-EF domain score &lt; 22 (6.3 and 8.4, respectively; all P ≤ 0.006). Similar results were achieved considering only those patients (group 3) who had complete EF recovery after surgery.

Conclusions
We demonstrated that in preoperatively fully potent patients treated with BNSRP a lower satisfaction is expected when an IIEF-EF cut-off of 17 is used. Conversely, no difference was found using a cut-off of 22 or 26. Therefore, our results support that a cut-off of IIEF-EF ≥ 22 might represent a reliable score for defining EF recovery after BNSRP.
Silencing MaxiK Activity in Corporal Smooth Muscle Cells Initiates Compensatory Mechanisms to Maintain Calcium Homeostasis
Authors: Calenda Giulia , Suadicani Sylvia Ottilie , Iglesias Rodolfo , Spray David Conover , Melman Arnold , Davies Kelvin Paul 
Published: January 2011

ABSTRACTIntroductionThe MaxiK potassium channel is regulated by voltage and intracellular calcium, and plays a critical role in regulating intracellular calcium concentration ([Ca2+]i), which is the ultimate determinant of smooth muscle tone. Tight control of corpus cavernosum smooth muscle (CCSM) tone is critically important and misregulation can result in erectile dysfunction.AimBecause of the tight functional linkage of MaxiK and calcium channel activity, the aim of this study was to determine the effects of silencing and pharmacological inhibition of MaxiK on calcium homeostasis and intercellular calcium signaling in CCSM cells.MethodsWe compared changes in the basal intracellular [Ca2+]i and parameters defining intercellular calcium wave (ICW) spread in 48 hours MaxiK silenced CCSM cells vs. acute blockade of the channel with iberiotoxin. To analyze changes occurring in gene expression we performed micro-array analysis following MaxiK silencing for 48 hours.Main Outcome MeasuresChanges in Fura-2 fluorescence intensities were measured to evaluate basal [Ca2+]i levels and ICW parameters. Microarray analysis of global gene expression was performed.ResultsForty-eight hours after MaxiK silencing the basal [Ca2+]i, the ICW amplitude and spread among CCSM cells were not markedly different in silenced compared to mock transfected controls, whereas short-term blockade significantly increased basal [Ca2+]i level and amplified Ca2+ signaling among CCSM cells. Micro-array analysis showed that several genes within Ca2+ homeostasis and smooth muscle tone regulation pathways had significantly altered expression.ConclusionsOur results indicate that while short-term blockade of the MaxiK channel is associated with an increase in basal [Ca2+]i, Ca2+ homeostasis is restored during the 48 hours period following silencing. We hypothesize that the different pathways regulating [Ca2+]i and CCSM tone are linked through molecular crosstalk and that their coordinated regulation is part of a compensatory mechanism aimed to maintain Ca2+ homeostasis and CCSM tone.