bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quinazolines and 1,4‐benzodiazepines LXVIII. 5‐Heterocyclic‐substituted benzodiazepinones
Authors: Kalish Robert , Broger E. , Field George F. , Anion T. , Steppe Thomas V. , Sternbach Leo H. 
Published: April 2009

AbstractThe synthesis of a number of new 1,4‐benzodiazepin‐2‐ones containg the 2‐thiazolyl, 5‐isothiazolyl, 1‐rnethyl‐2‐imidazolyl. 1‐methyl‐5‐pyrazolyl, and 3,5‐dimethyl‐4‐isoxazolyl groups in the 5‐position of the benzodiazepine ring are described.
Electron‐impact induced fragmentation of 3‐hydroxy quinazoline‐2,4(1H,3H) dione, pyridopyrimidine‐2,4(1H,3H)diones, lumazine and alloxazine
Authors: Tserng Kou‐Yi , Bell Charles L. , Bauer Ludwig 
Published: April 2009

AbstractElectron‐bombardment of the N‐3‐hydroxy derivatives of the above‐mentioned condensed uracils revealed that the major fragmentations involved the heterocyclic ring. The most intense ion proved to be the M‐32 ion which was created by the loss of the NHOH radical from the molecular ion. Mechanisms for this transition are presented. Other fragmentations common to these systems are discussed and compared with those reported for the corresponding N‐3 deoxy analogs of the title compounds. The mass spectral fragmentations of the O‐methyl‐, N‐methyl‐ and O,N‐dimethyl derivatives of 3‐hydroxyquinazoline‐2,4(1H,3H)dione were analyzed and were consistent with those expected from these structures. Electron bombardment of the 3‐benzenesulfonyloxy derivatives of the title compounds resulted primarily in the scission of the sulfonate group in preference to that of the heterocyclic dione ring. These sulfonates also showed ions which indicated that a Lossen rearrangement had taken place in the mass spectrometer.
Equilibre prototropique de 4‐acylisoxazolin‐ et pyrazolin‐5‐ones
Authors: Maquestiau A. , Van Haverbeke Y. , Muller R. N. 
Published: April 2009

AbstractDan les milieux non associants, les 4‐acylisoxazoline‐ et pyrazolin‐5‐ones existent sous une forme énolique non chélatée. La structure résultant de l'énolisation du groupe 4‐acyl semble convenir à la description des dérivés examinés.
Reactivity of 3‐amino‐, 3‐halogeno‐, and 3‐nitro‐2‐pyrones and thiopyrones
Authors: El‐Kholy Ibrahim El‐Sayed , Mishrikey Marcos Michael , Fuid‐Alla Hassan Mostafa 
Published: April 2009

AbstractSubstituted pyrrole and furan‐2‐carboxylic acids were obtained from 3‐amino‐ and 3‐halogeno‐2‐pyrones. The reactions of several substituted 2‐pyrones and thiopyrones with different amines and carbonyl reagents were studied.
Reactions of 1‐alkylbenzimidazolium 3‐imines with acetylenic compounds and benzaldehyde
Authors: Tamura Yasumitsu , Hayashi Hironori , Nishimura Yoshiro , Ikeda Masazumi 
Published: April 2009

Abstract1‐Alkyl‐3‐aminobenzimidazolium salts react with dimethyl acetylenedicarboxylate or dibenzoylacelylene in the presence of base to produce unusual 1:1 adducts, 1‐(2′‐alkylaminophenyl)‐pyrazole derivatives. Treatment of the 3‐amino salts with benzaldehyde in the presence of alkali gives benzaldehyde 2‐(N,N‐acylalkylamino)phenylhydrazones. The same hydrazones are obtained by alkaline treatment of 1 ‐alkyl‐3‐benzaliminobenzimidazolium salts, which are prepared from the 3‐amino salts and benzaldehyde.
Spectral and structural correlations of 1,4‐ and 3,4‐dihydroquinazolines
Authors: Smith James G. , Sheepy John M. 
Published: April 2009

AbstractAlkylation of the nucleophilic addition product of 2,4‐diphenylquinazoline and organometallic derivatives produced a mixture of 1,4‐ and 3,4‐dihydroquinazoline dreivatives. The structures were established through pmr correlations of chemical shifts of the N‐CH3 groups produced when the alkylating agent was methyl iodide.Spectra (uv, pmr) of known open‐chain amidines were used to confirm the structures of the isomeric dimethyl 2,4‐diphenyldihydroquinazolines. The uv spectra of 2‐phenyl‐3,4‐dihydroquinazolines possessed an absorption maximum at 320 nm while the 1,4‐dihydroanalogues had a maximum at 290 nm. Characteristic absorptions in the 1550–1650 cm−1 region of the infrared spectra also differentiated these two groups of compounds. Removal of the 2‐phenyl substituent renders these correlations less reliable.
7,8‐Dioxochlorpromazine, synthesis and properties
Authors: Zirnis A. , Suzuki J. K. , Daly J. W. , Manian A. A. 
Published: April 2009

Abstract7,8‐Dihydroxychlorpromazine and 2‐chloro‐7,8‐dihydroxyphenothiazine were converted to the corresponding 7,8‐dioxo compounds by oxidation with tetrachloro‐o‐quinone. Spectral properties indicate that the 7,8‐dioxo compounds exist in zwitterionic forms reminiscent of aminochromes. The 7,8‐dioxochlorpromazine is proposed as a possible metabolite of chlorpromazine.
Studies on the synthese of heterocyclic compounds. Part DXCV. The stereochemistry of methyl O‐(4‐hydroxy‐3‐methoxycinnamoyl)reserpate
Authors: Kametani Tetsuji , Higa Terumi , Ihara Masataka , Fukumoto Keiichiro , Kajiwara Masahiro , Fujimoto Yasuo , Tanaka Yoshihiro 
Published: April 2009

AbstractThe stereochemistry of the title compound (1), which has an antihypertensive activity, was confirmed by chemical and spectroscopical evidences.
Synthesis of 5,6,7,8‐tetrahydro‐5‐oxopyrido[2,3‐d]pyrimidine‐6‐carbonitriles and ‐6‐carboxylic acid esters
Authors: Santilli Arthur A. , Wanser Stephen V. , Kim Dong H. , Scotese Anthony C. 
Published: April 2009

AbstractDieckmann ring closure reactions of 4‐[(2‐cyanoethyl)substituted amino]‐2‐phenyl‐5‐pyrimidinecarboxylates (Ha‐f) afforded several 5,6,7,8‐tetrahydro‐5‐oxo‐2‐phenylpyrido[2,3‐d]pyrimidine‐6‐ carbonitriles (IIIa‐f). The open‐chain intermediates (IIa‐f) were prepared by dechloroamination of 5‐carbethoxy‐4‐chloro‐2‐phenylpyrimidine (1a) with several 3‐substituted amino‐ propionitriles. Alkylation of the sodium salt of 5,6,7,8‐tetrahydro‐8‐methyl‐5‐oxo‐2‐phenyl‐pyrido[2,3‐d]pyrimidine‐6‐ carbonitrile (IIIa) with methyl iodide in DMF resulted in methylation at C‐6 to afford IV. Tosylation of IIIa in pyridine gave the corresponding tosyl ester (V) of the enolic form. Oxidative dehydrogenation at the 6,7‐position resulted when IIIa reacted with thionyl chloride, affording 5,8‐dihydro‐8‐methyl‐5‐oxo‐2‐phenylpyrido[2,3‐d]pyrimidine‐6‐ carbonitrile (VII). Dechloroamination of la or 5‐carbethoxy‐4‐chloro‐2‐methylthiopyrimidine (Ib) with ethyl 3‐ethylaminopropionate followed by Dieckmann cyclization of the resulting open‐chain intermediates gave the corresponding ethyl 5,6,7,8‐tetrahydro‐5‐oxopyrido[2,3‐d]pyrimidine‐6‐carboxylates IX'a and IX'b, respectively. These exist predominately in the enol form and undergo alkylation and oxidation reactions similar to IIIa.
A novel dehydrogenation occurring during the synthesis of the new heterocyclic system 1H‐pyrazolo[3,4‐b][2,7]naphthyridin‐8‐one
Authors: Winn Martin 
Published: April 2009

Abstract1,3‐Disubstituted‐5‐aminopyrazoles and N‐alkyl‐3‐carbethoxy‐4‐piperidones condense in refluxing acetic acid to give 1,3,6‐trisubstituted 4,5‐dihydro‐1H‐pyrazolo[3,4‐b][2,7]naphthyridin‐8(6H)ones (a new heterocyclic system) with loss of one molecule of hydrogen.
New polyazaheterocycles. 9‐Methyl‐di‐s‐triazolo[4,3‐a:4,3‐c]pyrimidine and 9‐methyl‐s‐triazolo[4,3‐c]tetrazolo[1,5‐a]pyrimidine
Authors: La Noce T. , Giuliani A. M. 
Published: April 2009

Abstract9‐Methyl‐di‐s‐triazolo[4,3‐a:4,3‐c]pyrimidine and 9‐methyl‐s‐triazolo[4,3‐c]tetrazolo[1,5‐a]pyrimidine have been synthetized from 4‐hydrazino‐7‐methyl‐s‐triazolo[4,3‐c]pyrimidine. Structural assignments based on nmr, ir and chemical manipulations are discussed.
Etude par spectrométrie de masse du diaza‐2,5 dioxa‐1,6 thia‐6a λ IV pentalègne et de ses analogues séléniés et tellurés
Authors: Perrier Michel , Pinel Raoul , Vialle Jean 
Published: April 2009

AbstractLes spectres de masse du diaza‐2,5 dioxa‐1,6 thia‐6a λ IV pentalène et de ses analogues séléniés et tellurés sont étudiés. Ces spectres montrent la trés bonne stabilité de ces produits sous l'impact électronique et une bonne reproductibilité des fragmentations indépendamment de la nature de l'hétéroatome (S, Se ou Te).
Entzündungshemmende wirkstoffe. III. Synthese und entzündungshemmende wirksamkeit aromatisch substituierter benztriazole
Authors: Kreutzberger Alfred , Van Der Goot Henderikus 
Published: April 2009

AbstractDie I‐Acyl‐benztriazole3a‐3jwurden durch Umsetzung der korrespondierenden Carbonsäure‐chloride2a‐2jmit Benztriazol (1) erhalten. I‐(3,4,5‐Trimethoxy‐benzoyl)‐ (3c) und I‐Phenoxy‐carbonyl‐benztriazol (3d) vermögen in dieser Gruppe die markantesten entzündungshemmenden Effekte auszulösen.
2‐Azacycl[3.2.2] azine. Polyhalogenation and nucleophilic displacement reactions
Authors: Fuenles Omar , Paudler William W. 
Published: April 2009

Abstract1,4‐Dibromo‐2‐azacycl[3.2.2] azine (2) when treated with methanolic sodium methoxide affords the I‐methoxy‐4‐bromo derivative (3).Perchloro‐2‐azacycl[3.2.2]azine (7) was prepared and treated with methanolic sodium methoxide to yield the 5‐methoxy (8) and 5,7‐dimethoxy (9) derivatives as major products, depending upon reaction conditions. Catalytic removal of the chlorine substituents of compounds 8 and 9 afforded the 5‐methoxy (10) and 5,7‐dimethoxy (11) derivatives. Treatment of compound 2 with butyllithium affords the I‐butyl derivative (5) of 2‐azacycl[3.2.2]azine, while treatment with zinc in acetic acid yields 4‐bromo‐2‐azacycl[3.2.2]azine (6). 4‐Formyl‐2‐azacycl[3.2.2]azine (12) when treated with phosphorus pentachloride affords the 1,3‐dichloro‐4‐formyl derivative 13. Possible rationals for the nucleophilic displacement are given.
The photochemical synthesis of novel heterocyclic compounds from s‐triazolo[4,3‐b]pyridazine
Authors: Bradshaw Jerald S. , Carlock John T. , Maas Garren E. 
Published: April 2009

Abstracts‐Triazolo[4,3‐b]pyridazine (I) photochemically reacted with cyclooctene, cyclododecene, bicyclo[2.2.2]oct‐2‐ene, bicyclo[2.2.1]hept‐2‐ene and indene to form tri and tetracyclic triazoles (II‐X). Generally, two or more products were formed. For example the reaction with cyclooctene gave 4a,5,7,8,9,10,10a,11‐octahydro‐11‐methylene‐6H‐cycloocta[4,5]‐pyrrole[1,2‐b]‐s‐triazole (II) and the corresponding 11‐cyanomethyl product (III). When I was reacted with open chain alkenes, various isomers of the substituted pyrrolo[1,2‐b]triazoles (XI‐XV) were formed. Since the reaction was not stereospecific, cycloaddition must be a two step process.
Synthesis of 1,3,4,9‐tetrahydro‐1‐alkylthiopyrano[3,4‐b]indole‐1‐acetic acids. The sulfur isoster of prodolic acid
Authors: Jirkovsky I. , Humber L. G. , Noureldin R. 
Published: April 2009

AbstractThe condensation of thiotryptophol with β‐ketoesters and successive hydrolysis of the intermediates afforded the title compounds which represent a novel ring system. The reaction of thiotryptophol with ethyl propiolate in the presence of sodium methoxide gave the unstable 1,3,4,9‐tetrahydrothiopyrano[3,4‐b]indole‐1‐acetic acid. One of the described products is the sulfur isoster of the potent antiinflammatory agent, prodolic acid. The sulfur compounds of the present study displayed lower antiinflammatory activities than the corresponding oxygen analogs. A simple preparation of thiotryptophol is described.
Pyridine nucleosides related to 5‐fluorocytosine
Authors: Nesnow Stephen , Heidelberger Charles 
Published: April 2009

Abstract4‐Amino‐5‐fluoro‐2‐pyridone (4) [5‐fluoro‐3‐deazacytosine] was isolated as the hydrochloride salt from the dealkylation of 4‐amino‐5‐fluoro‐2‐methoxypyridine (2), which was obtained from the reduction of 5‐fluoro‐2‐methoxy‐4‐nitropyridine‐N‐oxide (1). Acetylation of 2 gave 4‐acetamido‐5‐fluoro‐2‐methoxypyridine (3), which was condensed with 2,3,5‐tri‐O‐benzoyl‐D‐ribofuranosyl bromide to give the blocked nucleoside (8). Removal of the protecting groups gave 5‐fluoro‐3‐deazacytidine. Fusion of the trimethylsilyl derivative of 4 (10), with 2‐deoxy‐3,5‐di‐O‐p‐toluoyl‐D‐erythro pentofuranosyl chloride gave a mixture of the β and α‐anomers 12 and 13, which were separated and deblocked to yield 5‐fluoro‐2′‐deoxy‐3‐deazacytidine (14) and its α‐anomer (15). Several alkylated and acetylated derivatives of 2 were prepared as model compounds for use in the proof of structure.
Azaindoles. V. Pyrido(4,3‐b]indoles (γ‐carbolines) fonctionnalisés sur leur sommet 4: Synthèse en une seule étape
Authors: Ducrocq Claire , Civier Alain , André‐Louisfert Jeannine , Bisagni Emile 
Published: April 2009

AbstractDans le diphényléther bouillant, la phénylhydrazine réagit avec les dihydro‐1,2 oxo‐2 hydroxy‐4 pyridines pour donner les dihydro‐3,4 oxo‐4 (9H) pyrido[4,3‐b]indoles (γ‐carbolines) en une scule étape. L'halogène de leurs dérivés chlorés est déplacé par les agents nucléophiles, en particulier les amines secondaires, pour former des γ‐carbolines diversement substituées en 3,4.
Recherches en série triazépine‐1,2,4: II — Etude de la réaction de l'acétylacétate d'éthyle avec les diamino‐3,4 oxo‐5 dihydro‐4,5 triazines‐1,2,4
Authors: Lavergne J. P. , Viallefont Ph. , Daunis J. 
Published: April 2009

AbstractL'acétylacétate d'éthyle et les diamino‐3,4 oxo‐5 dihydro‐4,5 triazines‐1,2,4 portant en position 6 un atome d'hydrogène, un méthyle ou un phényle, se condensent a reflux du xylène pour donner par cyclisation compétitive, à coté des dioxo‐4,7 méthyl‐9 tétrahydro‐1,4,6,7 as‐triazino[4,3‐b]triazépines‐1,2,4 obtenues en trés faible proportion, deux produits bicycliques prépondérants: les dioxo‐4,9 méthyl‐7 tétrahydro‐1,4,8,9 as‐triazino[4,3‐b]triazépines‐1,2,4 et les méthyl‐2 oxo‐7 dihydro‐3,7 s‐triazolo[3,2‐c]triazines‐1,2,4. Lors de la condensation de l'acétylacétate d'éthyle et des méthylamino‐3 amino‐4 oxo‐5 dihydro‐4,5 triazines‐1,2,4,seules les dioxo‐4,9 diméthyl‐7,10 tétrahydro‐4,8,9,10 as‐triazino[4,3‐b]triazépines‐1,2,4 sont obtenues avec de bons rendements.
Reductive acetylation of nitro compounds. III. Chemical transformations in three thiophene systems
Authors: Klemm L. H. , Hsin Wilson 
Published: April 2009

AbstractNitro groups on thiophene ring systems are transformed directly into acetylamino functions in yields of 61–82% by means of a mixture of iron, acetic acid, and acetic anhydride at 50–105°. When a bromo suhstituent is also present on the ring partial hydrodebromination occurs during the reaction.
Chemical properties of N‐Benzoylimines of quinazoline, quinoxaline, and phthalazine
Authors: Tamura Yasumitsu , Miki Yasuyoshi , Nakamura Keiko , Ikeda Masazumi 
Published: April 2009

AbstractReactions of 1‐benzoylimino‐4‐phenylquinazolinium (I), 1‐benzoylimino‐3‐phenylquinox‐alinium (II), and 3‐benzoylimino‐1‐phenylphthalazinium betaines (III) with nucleophiles (hydroxide and cyanide ions) and 1,3‐dipolarophiles (acetylenic esters and maleimides) were investigated. Heating I in aqueous alkali gave 3‐phenylindazole, while similar treatment of II and III resulted in the formation of 1‐benzoylamino‐2‐oxo‐3‐phenylquinoxaline and 2‐benzoylamino‐1‐oxo‐4‐phenylphthalazine, respectively. Reaction of II and III with cyanide ion afforded 2‐cyano‐3‐phenylquinoxaline and 1‐cyano‐4‐phenylphthalazine in high yields, respectively. 1,3‐Dipolar cycloaddition reactions of I and III with dimethyl acetylenedicarboxylate and ethyl propiolate afforded primary 1:1 cycloadducts, while the reaction of II with dimethyl acetylenedicarboxylate gave a product which is formed by ring opening of a primary adduct. The reaction of I‐III with N‐methyl and N‐phenylmaleimides afforded the corresponding primary 1:1 cycloadducts in high yields, whose stereochemical assignment was made on the basis of nmr spectroscopy.
The synthesis of indazoles via 2,3‐dihydroindazoles
Authors: Zenchoff Gladys S. , Walser Armin , Fryer R. Ian 
Published: April 2009

AbstractThe preparation and oxidation of 2,3‐dihydroindazoles to 1H, 2H or 3H‐indazoles is described. A method for the synthesis of indazole 2‐oxides has been found. Oxidation of 2‐acetyl‐2,3‐dihydro‐3,3‐disubstituted indazoles 5a and 5c gave quinoid compounds 20a, 20b, 24a and 24b, which could be isomerized to 3H‐indazoles upon removal of the acetyl group. A quinoid compound 21 was also obtained on treatment of 5a with tetracyanoethylene.
Furannes et pyrroles disubstitues en 2,3. XVII. Structure des composés formés par eyanuration des halogénométhyl‐2 méthoxycarbonyl‐3 et −5 furannes
Authors: Rivalle C. , Bisagni K. , Lhoste J‐M. 
Published: April 2009

AbstractLa eyanuration du bromométhyl‐2 méthoxycarbonyl‐3 furanne fournit l'acétonitrile furannique correspondent provenant de la substitution normale à cǒté du méthyl‐2 méthoxycarbonyl‐3 cyano‐5 furanne et de deux autres sous‐produits inhabituels issus de la substitution du méthylène “active” du furylacétonitrile formé in‐situ. Les sous‐produits obtenus par cyanuration du chlorométhyl‐2 méthoxycarbonyl‐5 furanne sont du měme type et la structure de ces composés inusuels décrite dans la littérature est done erronée. II est montré par ailleurs que l'acide cyanométhyl‐2 furanne carboxylique‐3 permet d'aceéder à des furo[3,2‐c]pyridines disubstituées en 4,6.
The effect of electron donating groups on the stability of thiabenzenes
Authors: Pirelahi Hooshang , Abdoh Yahya , Hadjmirsadeghi Faezeh , Sagherichi Hasan 
Published: April 2009

Abstract1‐(p‐Methoxyphenyl)‐2,4,6‐triphenylthiabenzene (X) has been synthesized and shown to be more stable than the 1‐phenyl analog. 1‐Phenyl‐2,4,6‐tri(p‐methoxyphenyl)thiabenzene (XVI) was not stable enough to be isolated in pure form and rearranged readily to the isomeric 2‐and 4‐thiopyrans. Only the pure 4‐phenyl‐2,4,6‐tri(p‐methoxyphenyl)thiopyran (XVIII) could be isolated.
Dibenz[b,f]oxepin and thiepin radical anions. Conjugative properties of sulfur in its different oxidation states
Authors: Leardini R. , Placucci G. 
Published: April 2009

AbstractThe radical anion of dibenz[b,f]oxepin has been investigated by esr spectroscopy and the relative coupling constants compared with dibenzo[b,f]thiepin. In both cases assignments were obtained using a theoretical method (INDO). In addition radicals from dibenzo[b,f]thiepin sulfoxide and sulfone could be detected and, unusually, the free electron density on carbon atoms of the radical anion containing a sulfonyl group is larger than that on carbons of radical anions containing a sulfide or a sulfoxide group.
New synthetic approaches to 3‐carhoxamides of 4‐hydroxy‐2H‐1,2‐benzothiazine 1,1‐dioxide
Authors: Lombardino Joseph G. , Watson Harry A. 
Published: April 2009

AbstractTwo new synthetic approaches to the title compounds are reported. In the first of these, starting with N‐carbobenzyloxysarcosine, four synthetic steps are employed to finally assemble the C3C4 bond of the 1,2‐benzothiazine ring. In the second approach, an enol ether is employed as a protecting group to allow formation of the 3‐carboxamide function, which is followed by cleavage of the ether function to yield the desired 4‐hydroxy‐1,2‐benzothiazine‐3‐carboxamide 1,1‐dioxide.
A new ring transformation of 3‐halo‐2‐azidopyridine 1‐oxides. A novel synthesis of 1,2‐oxazin‐6‐ones
Authors: Abramovitch Rudolph A. , Shinkai Ichiro , Cue Berkeley W. , Ragan Francis A. , Atwood Jerry L. 
Published: April 2009

AbstractThe course of the thermal ring‐opening and recyclization of 2‐azidopyridine 1‐oxides is radically altered by the presence of a 3‐halo substituent. Provided the 6‐position is blocked, recyclization leads to a 6‐cyano‐6‐halo‐1,2‐oxazine which hydrolyzes very readily to the 6H‐1,2‐oxazin‐6‐one. The structure of 4‐bromo‐3‐methyl‐6H‐1,2‐oxazin‐6‐one so obtained was confirmed by single crystal X‐ray analysis. If the 6‐position is not blocked, the product undergoes a further ring opening to give (Z)‐β‐cyanoacrylates.
2,3,5,6‐Tetramethylmorpholine. I
Authors: Hernestam Sven , Stenvall Gillis 
Published: April 2009

AbstractThe separation and characterization of the six possible isomers of 2,3,5,6‐tetramethylmorpholine are described. Synthetic routes for the preparation of any isomer in fair yield from easily accessible intermediates are reported.
Synthesis ofS(+) andR(‐)‐3‐(2‐aminopropyl)indole from ethyl‐D‐ andL‐tryptophanate
Authors: Repke David B. , Ferguson Wilfred J. 
Published: April 2009

AbstractA stereospecific requirement for hallucinogenesis applies to certain molecules containing an asymmetric center. Thus, only theR‐isomers of substituted phenylisopropylamines and lysergic acid diethylamide are psychotomimetic. The enantiomers of a minor hallucinogen,S(+)‐ andR(‐)‐3‐(2‐aminopropyl)indole (α‐methyltryptamine) (6aand6b) were synthesizedviaa 5‐step manipulation fromD‐ andL‐tryptophan ethyl ester hydrochloride, respectively. Optical purity of these two isomers was determined by pmr spectroscopy of their complexes with a europium chiral shift reagent using the indole C2H signal.
Cyclol derivatives related to ergocornine
Authors: Portlock David E. , Ghosh Anil C. , Schwarzel William E. , Kurtz Richard R. , Boger Eliahu , Dalzell Haldean C. , Razdan Raj K. 
Published: April 2009

AbstractNovel cyclol derivatives (Table 1, 15, 16) similar in structure to the peptide portion of ergocornine were synthesized. Detailed experimental procedures are given for the preparation of the cis‐13a and the unknown trans‐14a cyclol esters.
Reaction of hydroxylamine with 5‐aminooxazoles. A new route to isoxazoles
Authors: Clerin Daniel , Fleury Jean‐Pierre , Fritz Hans 
Published: April 2009

AbstractThe nucleophilic attack of hydroxylamine at the 5 position of 2‐aryl‐4‐trifluoroacetyl‐5‐amino‐oxazoles leads to a mixture of stereoisomeric isoxazolines. Dehydration of these isomeric isoxazolines in the presence of trifluoroacetic anhydride gives 3‐amino‐4‐acylamino‐5‐trifluoromethylisoxazoles. The structures and spectroscopic data of these compounds are discussed.
Azo‐1,3,5‐triazines
Authors: Loew P. , Weis C. D. 
Published: April 2009

AbstractThe synthesis of variously substituted bis‐triazinylhydrazines and their subsequent oxidation preferably with chlorine in a two‐phase system to azo‐1,3,5‐triazines starting from cyanuric chloride is reported. Reaction of ethoxycarbonylhydrazine with cyanuric chloride followed by oxidation gave access to mono‐ and bis‐ethoxycarbonyl‐1,3,5‐triazines, respectively. Azo‐1,3,5‐triazines proved to be very reactive dienophiles.
Tetrahydropyridines and furans from the reaction of 4‐t‐butylpyridine 1‐oxide with t‐butyl and 1‐adamantyl mercaptan
Authors: Kokosa John M. , Chu Ih , Bauer Ludwig , Egan Richard S. 
Published: April 2009

AbstractThe reaction of 4‐t‐butylpyridine 1‐oxide (1) with t‐butyl or 1‐adamantyl mercaptan in acetic anhydride yielded the expected 2‐ and 3‐alkylthio‐4‐t‐butylpyridines and 1‐acetyl‐2,6‐bis‐(alkylthio)‐3‐acetoxy‐4‐t‐butyl‐ and the unexpected 1‐acetyl‐2‐acetoxy‐3,6‐bis(alkylthio‐4‐t‐butyl‐1,2,3,6‐tetrahydropyridines. The addition of t‐butyl mercaptan to a solution of 1 in acetic anhydride containing triethylamine produced the expected 1‐acetyl‐2‐t‐dmtylthio‐3‐acetoxy‐4‐t‐butyl‐6‐hydroxy‐1,2,3,4‐tetrahydropyridine (6a) and the unexpected 1‐acetyl‐2,6‐bis(hydroxy)‐3‐t‐butylthio‐4‐t‐butyl‐1,2,3,6‐tetrahydropyridine. Mild alkaline hydrolysis of 6a yielded predominantly 2‐[(acetamido) (t‐butylthio)methyl]‐3‐t‐butyl‐5‐hydroxy‐2,5‐dihydrofuran. The latter was converted by very mild acidic reagents to the corresponding furan and with 2,4‐dinitrophenylhydrazine and sulfuric acid furnished 3‐t‐butylfurfural 2,4‐dinitrophenyl‐hydrazone.
Recherches en série azabenzodiazepine V. Synthése de bis s‐triazolo[4,3‐b:4,3‐d] triaze'pines‐1,2,4
Authors: Essassi E. M. , Lavergne J‐P. , Viallefont Ph. 
Published: April 2009

AbstractPar action de l'acide acétique et de l'acide formique sur des hydrazino‐8 s‐triazolo[4,3‐b]‐triazépines‐1,2,4 ou par cyclisation d'acylhydrazino‐8 s‐triazolo[4,3‐b]triazépines‐1,2,4 les bis s‐triazolo[4,3‐b:4,3‐d]triazépines‐1,2,4 ont été synthétisées pour la première fois.
Pyridyl phosphates from the reaction of sodium pyridinates, dialkyl phosphite and carbon tetrachloride
Authors: Wang C. S. , Mintz M. J. 
Published: April 2009

AbstractA convenient method for preparing pesticidal pyridyl phosphates from the reaction of sodium halopyridinales, dialkyl phosphite and carbon tetrachloride is described. The dialkyl phosphonato anion as an intermediate in this reaction is proposed.