bluuebunny/crossref_metadata_2025_split huggingface dataset:
Live Birth following Treatment of Metastatic Cerebral Choriocarcinoma
Authors: Gupta Vineeta , Nanda Anuja , Sharma Arti , Choudhary Priyanka , Kudesia Sandip 
Published: September 2011

ABSTRACT
Choriocarcinoma is a malignant tumor of trophoblastic tissue and constitutes about 30 to 40% of the trophoblastic neoplasia cases. Early hematogenous spread is characterstic of choriocarcinoma. We report a case of metastatic cerebral choriocarcinoma in a 23-year-old female with appearance of acute neurological signs following spontaneous intracerebral hemorrhage as the initial presentation. She underwent successful treatment of choriocarcinoma with chemotherapy (EMA-CO regime) and was able to have normal baby with good apgar score. The case emphasizes the importance of suspecting an underlying choriocarciroma in women of child bearing age group presenting with spontaneous cerebral hemorrhage and an uncomplicated term delivery can be expected after complete chemotherapy for GTN.
A Hospital based Randomized Controlled Trial to Evaluate the Effectiveness of Kegel's Exercise on Postpartum Perineal Laxity
Authors: Raddi Sudha A , Sheeba TT , Ballad MB 
Published: September 2011

ABSTRACT

Objectives
The objectives of the study are to: (i) Assess the perineal muscle strength of postnatal mothers after vaginal delivery in the experimental and control groups before and after the intervention. (ii) Evaluate the effectiveness of Kegel's exercise on perineal laxity in the experimental group compared to control group.

Methods
This single blinded randomized controlled trial at a 1000 bedded tertiary care teaching hospital in India, enrolled 290 postnatal mothers between 20 and 40 years who had vaginal delivery with < 2 on modified Oxford grading scale as measured by per vaginal digital examination. The subjects were randomized into experimental and control groups. The experimental group received instructions to perform Kegel's exercises along with routine postnatal care while the control group received advice on routine postnatal care. Two follow-up assessments were done at 6 and 10 weeks. The primary outcome measure was increase in Oxford grading score.

Results
Major findings of the study were: The mean perineal muscle strength assessment scores noted before the intervention and during first and second postintervention assessments were 1.5 ± 0.52, 3.58 ± 0.51 and 4.28 ± 0.57 respectively for the experimental group and 1.56 ± 0.55, 2.41 ± 0.52 and 3 ± 0.51 respectively for the control group. Comparison of these scores between the groups by unpaired t-test yielded p-value of < 0.0001 suggesting high significant difference in favor of the experimental group. However, no additional benefit was observed after Kegel's exercise in the mothers who had episiotomy during vaginal delivery.

Conclusion
The Kegel's exercise is effective to reduce perineal laxity and hence should be included as a part of routine postnatal care.
Intensive short‐term chemotherapy regimen induces high remission rate (over 90%) and event‐free survival both in children and adult patients with advanced sporadic Burkitt lymphoma/leukemia
Authors: Todeschini Giuseppe , Bonifacio Massimiliano , Tecchio Cristina , Balter Rita , Carli Giuseppe , Stefani Piero Maria , Adami Fausto , Zamò Alberto , Tos Angelo Paolo Dei , Marino Filippo , Gherlinzoni Filippo , Marradi Pierluigi , Semenzato Giampietro , Pizzolo Giovanni 
Published: September 2011

AbstractThe optimal treatment of advanced sporadic Burkitt lymphoma in adults is still a matter of debate. The salutary results of pediatric therapies did open the road for improving the adult outcome. Between May 1988 and March 2009, 71 consecutive patients—46 adults, 25 children—affected by Burkitt lymphoma/leukemia were treated with the same intensive pediatric protocol alternating vincristine, adriamycine and fractionated ciclophosphamide (phase A) with high dose methotrexate and high dose cytarabine (phase B) in four Italian institutions. Eighty‐nine per cent of patients were in Stage III–IV or had L3 leukemia. Complete remissions were 67/71 (94.4%), 24/25 (96%) in children, and 43/46 (93.5%) in adults. Toxic deaths were 3/71 (4.2%), all in adults. There were nine relapses (one in children, eight in adults), all but one observed early. After a median observation of 94 months (range 23–275), the Event–Free Survival rate is 92% in children and 71.7% in adults (P = 0.067). The 23 more recent adults received also rituximab, without differences in outcome as compared to patients who did not. Our experience confirms that such an intensive pediatric‐derived chemotherapy is feasible and improves the long‐term outcome of adults with advanced Burkitt lymphoma. Am. J. Hematol., 2012. © 2011 Wiley Periodicals, Inc.
Transcriptome‐wide gene expression in a rat model of attention deficit hyperactivity disorder symptoms: Rats developmentally exposed to polychlorinated biphenyls
Authors: Sazonova Nadezhda A. , DasBanerjee Tania , Middleton Frank A. , Gowtham Sriharsha , Schuckers Stephanie , Faraone Stephen V. 
Published: September 2011

AbstractPolychlorinated biphenyls (PCB) exposure in rodents provides a useful model for the symptoms of Attention deficit hyperactivity disorder (ADHD). The goal of this study is to identify genes whose expression levels are altered in response to PCB exposure. The brains from 48 rats separated into two age groups of 24 animals each (4 males and 4 females for each PCB exposure level (control, PCB utero, and PCB lactational)) were harvested at postnatal days 23 and 35, respectively. The RNA was isolated from three brain regions of interest and was analyzed for differences in expression of a set of 27,342 transcripts. Two hundred seventy‐nine transcripts showed significant differential expression due to PCB exposure mostly due to the difference between PCB lactational and control groups. The cluster analysis applied to these transcripts revealed that significant changes in gene expression levels in PFC area due to PCB lactational exposure. Our pathway analyses implicated 27 significant canonical pathways and 38 significant functional pathways. Our transcriptome‐wide analysis of the effects of PCB exposure shows that the expression of many genes is dysregulated by lactational PCB exposure, but not gestational exposure and has highlighted biological pathways that might mediate the effects of PCB exposure on ADHD‐like behaviors seen in exposed animals. Our work should further motivate studies of fatty acids in ADHD, and further suggests that another potentially druggable pathway, oxidative stress, may play a role in PCB induced ADHD behaviors. © 2011 Wiley Periodicals, Inc.
The Influence of Exocyclic Stereochemistry on the Tethered Aminohydroxylation Reaction
Authors: Donohoe Timothy J. , Lacy Adam R. , Rathi Akshat H. , Walter Daryl S. 
Published: September 2011

AbstractA new strategy that employs an exocyclic stereocenter to effect diastereocontrol in the tethered aminohydroxylation (TA) reaction is applied to the stereoselective synthesis of a range of amino alcohols in good to excellent yields, and with anti selectivities of up to 20:1. The influence of the reaction conditions and substrate parameters on the level of diastereocontrol is described. Furthermore, an “inside alkoxy” model is employed to rationalize the sense and degree of stereoselectivity observed in these systems.
Selective signaling of fluoride anion based on imidazole moieties
Authors: Zheng Yuhui , Wang Qianming , Tan Chaoliang 
Published: September 2011

ABSTRACTThe imidazole ring unit in both 2‐(2′‐hydroxyphenyl)‐benzimidazole (ligand a) and a europium(III) complex exhibited specific luminescent responses in the presence of fluoride anions. UV‐visible and 1H‐nuclear magnetic resonance spectra showed that the NH bond of the imidazole ring can form a hydrogen bond with added fluoride anions. The detection limits are 5 × 10−6 m for organic ligand and 1.0 × 10−6 m for the europium complex respectively. The response times are less than 3 s. The europium complex exhibits a linear response in a concentration range lower than 1.0 × 10−6 m (Y = −666.86X + 730.1). Copyright © 2011 John Wiley & Sons, Ltd.
Dehydroabietic acid activates peroxisome proliferator‐activated receptor‐γ and stimulates insulin‐dependent glucose uptake into 3T3‐L1 adipocytes
Authors: Takahashi Nobuyuki , Yao Ran , Kang Min‐Sook , Senda Mari , Ando Chieko , Nishimura Kanako , Goto Tsuyoshi , Hirai Shizuka , Ezaki Yoichiro , Kawada Teruo 
Published: September 2011

AbstractDehydroabietic acid (DAA) is a food‐derived terpenoid with various bioactivities. Our previous study has revealed that DAA activates peroxisome proliferator‐activated receptor‐γ (PPARγ) in luciferase assay and suppresses chronic inflammation in obese adipose tissues. In this study, we examined the effects of DAA on adipocyte differentiation. DAA treatment stimulated the adipocyte differentiation of 3T3‐L1 preadipocytes. The DAA treatment increased the mRNA expression levels of adipocyte differentiation marker genes such as aP2, lipoprotein lipase (LPL), and PPARγ. In particular, the expression level of adiponectin, which is an adipocytokine with stimulatory effects on insulin sensitivity, was increased at both the mRNA and protein levels by the DAA treatment. Moreover, the DAA treatment stimulated insulin‐dependent glucose uptake into differentiated 3T3‐L1 adipocytes. These findings indicate that DAA stimulates adipocyte differentiation and insulin sensitivity in 3T3‐L1 cells, suggesting that DAA is a valuable food‐derived compound for the management of metabolic syndrome.
The effect of HMGB1 A box on lung injury in mice with acute pancreatitis
Authors: Kong Xiangqian , Zhang Caiqing , Jin Xing , Wu Xuejun , Zhang Shiyi , Zhong Zhenyue , Feng Qian , Liu Ting , Yuan Hai 
Published: September 2011

AbstractThe objective of this study is to observe the effect of high‐mobility group protein B1 A Box (HMGB1 A) box on lung injury in mice with acute pancreatitis and its effect on the level of high‐mobility group protein B1 (HMGB1) in lung, to explore the mechanism. A total of 60 male Institute of Cancer Research mice were randomly divided into control group (n = 30) and treatment group (n = 30). Severe acute pancreatitis mice model was induced by 20% L‐Arg intraperitoneal injection. The recombination HMGB1 A box was used in treatment after modeling. All the mice were killed under anesthesia at 24 and 48 h after the modeling injection. The level of HMGB1 and activity of myeloperoxidase (MPO) in lung were measured. The pathological changes of lung were observed. The level of HMGB1 in lung of A box treatment group decreased more significantly 24 h and 48 h after modeling compared with control group. The activity of MPO in lung of A box treatment group decreased more significantly 24 h after modeling compared with control group. The lung tissue pathologic score of A box treatment group decreased more significantly 48 h after modeling compared with control group. HMGB1 expression levels in the lungs were positively related to histological score of injured lung in acute pancreatitis. It indicates that HMGB1 A box is remarkably protective to lung injury induced by acute pancreatitis.
Simultaneous determination of simvastatin, lovastatin and niacin in human plasma by LC‐MS/MS and its application to a human pharmacokinetic study
Authors: Rao Pilli Nageswara , Mullangi Ramesh , Kuamr Inamadugu Jaswanth , Kumari Nallapati Indira , N Seshagiri Rao J. V. L. 
Published: September 2011

ABSTRACTA simple, sensitive and specific LC–MS/MS method for simultaneous determination of simvastatin (SV), lovastatin (LV) and niacin (NIA) in human plasma was developed and validated on API‐4000 in positive ion mode. Nevirapine was used as internal standard (IS). The assay procedure involved a simple one‐step liquid–liquid extraction of SV, LV, NIA and the IS from plasma into ethyl acetate. Separation of SV, LV, NIA and the IS was achieved on an Alltima C18 column with a mobile phase consisting of 5 mm ammonium acetate (pH 4.5) and acetonitrile (20:80, v/v) pumped at a flow rate of 1 mL/min. Nominal retention times obtained for SV, LV, NIA and IS were 2.12, 1.67, 0.50 and 0.65 min, respectively. The lower limits of quantification (LLOQ) for SV, LV and NIA were 0.10, 0.10 and 25.2 ng/mL, respectively. The response function was established for the range of concentrations 0.10–101 ng/mL for SV and LV, and 25.2–5020 ng/mL for NIA, with a coefficient of correlation of >0.99 for all the compounds. Method validation was performed as per FDA guidelines and the results met the acceptance criteria. The proposed method was found to be applicable to clinical studies. Copyright © 2011 John Wiley & Sons, Ltd.
Private Benefits of Managerial Control, Government Ownership, and Acquirer Returns: Evidence from the Chinese State‐Controlled Listed Companies
Authors: Li Shuangyan , Feng Genfu , Cao Guangjun 
Published: September 2011

AbstractThis article examines how government ownership affects the relationship between private benefits of managerial control, measured as excessive overhead expenses, and profitability of acquirers. A total of 246 merger and acquisition (M&A) events from Chinese state‐controlled listed companies (CSCLCs) between 2001 and 2006 constitutes the analytical sample. Under a low level of government shareholding, private benefits of managerial control positively correlated with acquirer announcement returns. However, there was no relationship between private benefits of managerial control and acquirer announcement returns under a high level of government shareholding. The implications of these findings for scholarship and practice are discussed. Copyright © 2011 ASAC. Published by John Wiley & Sons, Ltd.
Influence of bubbles characteristics on the skin friction and velocity gradient on solid sphere
Authors: Essadki A. H. , Nikov I. , Delmas H. 
Published: September 2011

AbstractA detailed study of the effects of individual bubbles at high gas flow‐rate has shown, that the dominant influence on skin friction over a solid sphere is the bubble volume in compared to bubble frequency. Nevertheless the bubble frequency is very important in case of low gas flow‐rate. Referring to bubbles produced by a gas distributor, statistical and spectral analyses were performed to study the influence of bubbling on exposure time and magnitude of fluctuations. Referring to a calibrated bubble train, the existence of critical frequency is demonstrated. A bubble with larger volume and a mobile, oscillatory surface generates larger velocity gradient. In the case of gas distribution, histograms of the velocity gradient for a 2 mm glass sphere creating bubble coalescence reveal the maximum exceeds 48 000 s−1 in the front zone and 2000 s−1 in the rear zone (θ = 180°). For 5 mm plastic spheres creating bubble break‐up, the maximum of the velocity gradient is only 8100 s−1 for the front part of the sphere and 2000 s−1 in the rear zone.
Innovative cancer therapies
Authors: Khayat David 
Published: September 2011

AbstractThe costs of cancer care are rising, and spending on expensive innovative anticancer agents is likely to come under scrutiny as health care payers are confronted by the challenge of resource limits in the face of infinite demand. Indirect costs account for the major part of total attributable costs of cancer and are dominated by the cost of mortality in individuals of working age (who therefore do not contribute to economic productivity). Although cancer is a leading cause of morbidity and premature mortality, in 2007, it was estimated that cancer accounted for only around 6% of the total health care costs in Europe. It is estimated that cancer drug costs constitute around 12% of total direct cancer costs and 5% of the costs of all drugs. Countries vary in their uptake of novel anticancer agents. However, even in France—a leading nation for the use of these agents—the costs of innovative anticancer drugs accounted for <0.6% of total health care expenditure in 2006. Population‐level data suggest that novel therapies have contributed (together with advances in screening and other aspects of care) to improvements in survival from cancer. If this is the case, then the potential reduction in the associated indirect costs could exceed the direct costs associated with the uptake of innovative drug therapies. Further research is required to establish the costs and benefits of novel agents in routine practice. Cancer 2012. © 2011 American Cancer Society.
A prospective protocol for nasopharyngeal carcinoma in children and adolescents
Authors: Casanova Michela , Bisogno Gianni , Gandola Lorenza , Cecchetto Giovanni , Di Cataldo Andrea , Basso Eleonora , Indolfi Paolo , D'Angelo Paolo , Favini Francesca , Collini Paola , Potepan Paolo , Ferrari Andrea ,   on behalf of the Rare Tumors in Pediatric Age Group
Published: September 2011

AbstractBACKGROUND:Nasopharyngeal carcinoma (NPC) is very rare in childhood. It differs from its adult counterpart in the prevalence of the nonkeratinizing, undifferentiated subtype and by an advanced clinical stage at onset and better chances of survival. The risk of long‐term treatment‐related toxicity also may be a more important issue in younger individuals.METHODS:A prospective chemoradiotherapy protocol for pediatric NPC was started in Italy in 2000 within the framework of the Rare Tumors in Pediatric Age (TREP) project. Three courses of cisplatin/5‐fluorouracil induction chemotherapy were followed by radiotherapy (doses up to 65 grays) with concomitant cisplatin.RESULTS:Forty‐six patients (ages 9‐17 years) were considered eligible for the study over a 10‐year period. The ratio of observed to expected cases based on epidemiological data was approximately 1 for both children and adolescents. All but 1 patient had lymph node involvement, and 5 patients had distant metastases. The rate of response to primary chemotherapy was 90%. The 5‐year overall and progression‐free survival rates were 80.9% and 79.3%, respectively (median follow‐up, 62 months). The only statistically significant prognostic variable was the presence or absence of distant metastases. A 65% incidence of late sequelae was reported.CONCLUSIONS:This study demonstrates the feasibility and efficacy of a prospective protocol even for such rare tumors as pediatric NPC. The use of lower radiotherapy doses than those used in adults did not affect locoregional failure rates. Long‐term follow‐up will be needed to obtain more information on both survival and treatment sequelae. The next objective will be to establish broader, international prospective cooperation schemes. Cancer 2011. © 2011 American Cancer Society.
The impact of biomarkers in multivariate algorithms for bladder cancer diagnosis in patients with hematuria
Authors: Abogunrin Funso , O'Kane Hugh F. , Ruddock Mark W. , Stevenson Michael , Reid Cherith N. , O'Sullivan Joe M. , Anderson Neil H. , O'Rourke Declan , Duggan Brian , Lamont John V. , Boyd Ruth E. , Hamilton Peter , Nambirajan Thiagarajan , Williamson Kate E. 
Published: September 2011

AbstractBACKGROUND:We appraised 23 biomarkers previously associated with urothelial cancer in a case‐control study. Our aim was to determine whether single biomarkers and/or multivariate algorithms significantly improved on the predictive power of an algorithm based on demographics for prediction of urothelial cancer in patients presenting with hematuria.METHODS:Twenty‐two biomarkers in urine and carcinoembryonic antigen (CEA) in serum were evaluated using enzyme‐linked immunosorbent assays (ELISAs) and biochip array technology in 2 patient cohorts: 80 patients with urothelial cancer, and 77 controls with confounding pathologies. We used Forward Wald binary logistic regression analyses to create algorithms based on demographic variables designated prior predicted probability (PPP) and multivariate algorithms, which included PPP as a single variable. Areas under the curve (AUC) were determined after receiver‐operator characteristic (ROC) analysis for single biomarkers and algorithms.RESULTS:After univariate analysis, 9 biomarkers were differentially expressed (t test; P < .05). CEA AUC 0.74; bladder tumor antigen (BTA) AUC 0.74; and nuclear matrix protein (NMP22) 0.79. PPP included age and smoking years; AUC 0.76. An algorithm including PPP, NMP22, and epidermal growth factor (EGF) significantly improved AUC to 0.90 when compared with PPP. The algorithm including PPP, BTA, CEA, and thrombomodulin (TM) increased AUC to 0.86. Sensitivities = 91%, 91%; and specificities = 80%, 71%, respectively, for the algorithms.CONCLUSIONS:Addition of biomarkers representing diverse carcinogenic pathways can significantly impact on the ROC statistic based on demographics. Benign prostate hyperplasia was a significant confounding pathology and identification of nonmuscle invasive urothelial cancer remains a challenge. Cancer 2011. © 2011 American Cancer Society.
A Surveillance, Epidemiology and End Results (SEER) program comparison of adult and pediatric Wilms' tumor
Authors: Ali Arif N. , Diaz Roberto , Shu Hui‐Kuo , Paulino Arnold C. , Esiashvili Natia 
Published: September 2011

AbstractPURPOSE:To compare the characteristics and outcome of adults and children diagnosed with Wilms' tumor.METHODS:The Surveillance, Epidemiology and End Results (SEER) database was analyzed for patients diagnosed with Wilms' tumor between 1973 and 2007. Patients were stratified into pediatric (<16 years) or adult (≥16 years) groups. Overall survival was the primary endpoint.RESULTS:A total of 2342 patients (2190 pediatric and 152 adult) with Wilms' tumor were identified. Adult patients were statistically more likely to be staged as localized than pediatric patients (62.5% vs 44.7%), to not receive any lymph node sampling (57.9% vs 16.2%), and to not receive any radiation treatment (74.3% vs 53.9%). Adults had a statistically worse overall survival (OS) than pediatric patients (5‐year OS, 69% vs 88%, P<.001) despite the earlier tumor stage. When stratified by treatment era, the OS of all patients treated after 1981 was statistically higher than those treated before (5‐year OS, 75% vs 89%, P<.001). Significant predictors of OS on univariate analysis for adults included treatment era, SEER stage, surgery, and radiation treatment. Significant predictors of OS on multivariate analysis of all patients included adult status (hazard ratio, 4.14; P<.001), treatment era, SEER stage, and surgery.CONCLUSION:Adults in the SEER database had statistically worse OS than pediatric patients despite previous studies showing comparable outcome when treated on protocol. The worse outcome of SEER adults likely stems from incorrect diagnosis, inadequate staging and undertreatment. We recommend lymph node samplings for all adult Wilms' tumor patients and collaboration with pediatric oncologists. Cancer 2012. © 2011 American Cancer Society.