bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gastrointestinal Surgical Outcomes Study (GISOS): a 30-day monocentric prospective cohort study in Ethiopia
Authors: Awedew Atalel Fentahun , Asefa Zelalem 
Published: May 2024

ObjectiveThe impact of perioperative mortality and morbidity extends globally, playing substantial roles in mortality rates, levels of disability and economic consequences. This study was primarily designed to provide insights into the surgical outcomes of gastrointestinal surgeries carried out in a high-volume centre in Ethiopia in the year 2023.DesignA 30-day prospective cohort observational study employed.SettingHigh volume surgical specialised hospital in Ethiopia.ParticipantsAll adult patients who had abdominal surgery.Outcome measures30th-day postoperative mortality and complications.ResultsDuring this prospective observational study, data from 259 patients were collected. This prospective observational study found that 30-day complication rate was 30.5%. Surgical site infection is the leading complications (15.8%) followed by postop acute kidney injury (9.3%). Malignant pathology (adjusted OR (AOR)=1.43 (1.01 to 3.06); p=0.035, ASA III (AOR=4.00 (1.01 to 16.5); p=0.049), ECOG III (AOR=2.8 (1.55 to 7.30); p=0.025) and comorbidity (AOR=2.02 (1.02 to 3.18); p=0.008) had statistically significant association with 30-day complication rates. We also found that a 30-day mortality rate was 14.3%. Emergency surgery (AOR=5.53 (1.4 to 21.6); p=0.014), Eastern Cooperative Oncology Group III (AOR=8.6 (1.01 to 74.1); p=0.0499), American Society of Anesthesiology III (AOR=12.7 (1.9 to 85.5); p=0.009) and comorbidity (AOR=7.5 (1.4 to 39.1); p=0.017) had statistical significance association with a 30-day mortality rate after gastrointestinal surgery.ConclusionThe findings of this study indicated that postoperative mortality and complications were alarmingly high, which highlights the need for innovative solutions to lower postoperative mortality and complications.
Perceived social support and professional quality of life of health professionals during COVID-19 pandemic in Nepal: a cross-sectional study
Authors: Singh Bikram Kumar , Pandey Samip , Humagain Urja , Bista Pariwesh Raj , Pahari Durga Prasad 
Published: May 2024

ObjectiveTo assess the perceived social support and professional quality of life (ProQOL) among healthcare professionals during COVID-19 pandemic in Nepal, encompassing both positive (compassion satisfaction) and negative (compassion fatigue) dimensions as well as the factors associated with them.DesignA cross-sectional web-based study.SettingNepalParticipantsWe carried out a convenience sampling technique to enrol 313 health professionals aged 18–60 years old.Outcome measuresWe employed the ProQOL V.5 questionnaire (comparing 30 self-report items) and the Multidimensional Scale of Perceived Social Support with 12 items to assess the ProQOL and social support, respectively. A χ2test was performed to determine associated factors of different dimensions of ProQOL.ResultsThe study included a total of 313 participants, mostly consisting of frontline health workers. More than one-third of the participants worked in places where precautionary measures were insufficient. However, the majority of them (73.8%) had high social support. Concerning the ProQOL, the percentage of health professionals that had moderate compassion satisfaction (CS), moderate Burnout (BO) and moderate secondary traumatic stress (STS) were 57.5%, 58.2% and 75.4%, respectively. Factors like sex, marital status, profession, work-shift, type of health institution and status of precautionary measures at the workplace were associated with the different dimensions of ProQOL at the significance level of 0.05.ConclusionThis study findings revealed a considerable proportion of BO and STS among health professionals during COVID-19 pandemic in Nepal. Implementation of appropriate interventions and support systems are needed to enhance CS, alleviate BO and mitigate STS among health professionals to combat future health emergencies.
Prevalence and viral suppression of hepatitis B virus infection among people living with HIV on antiretroviral therapy in Sierra Leone
Authors: Song Jin-Wen , Lakoh Sulaiman , Chen Si-Yuan , Jalloh Mohamed Boie , Sevalie Stephen , Baldeh Mamadu , Nyambe Mohamed K , Nicholas Victoria Donicia , Yendewa George , Wang Fu-Sheng , Yang Guang 
Published: May 2024

ObjectiveSub-Saharan Africa is one of the regions with the highest burdens of HIV and hepatitis B virus (HBV), but data on the impact of antiretroviral therapy (ART) on HBV DNA suppression is limited. In this study, we aimed to determine the prevalence and associated factors of a positive hepatitis B surface antigen (HBsAg) among people living with HIV, and assess the suppression of ART on HBV replication in people living with HIV in Sierra Leone.MethodsA cross-sectional study was designed to recruit people living with HIV aged 18 years or older in ten public hospitals in Sierra Leone between August 2022 and January 2023. Statistical analyses were performed using R software. Logistic regression analysis was used to assess factors independently associated with positive HBsAg and HBV DNA suppression.ResultsOf the 3106 people living with HIV recruited in this study, 2311 (74.4%) were women. The median age was 36 years, 166 (5.3%) had serological evidence of HBV vaccination. The overall prevalence of HBsAg positivity was 12.0% (95% CI: 10.9% to 13.2%). Male sex (adjusted OR (aOR) 2.11, 95% CI: 1.67 to 2.68; p<0.001) and being separated (aOR 1.83, 95% CI: 1.06 to 3.16, p=0.031; reference group: being married) were independent predictors of HBsAg seropositivity. Among 331 people living with HIV and HBV receiving ART, 242 (73.1%) achieved HBV DNA suppression (below 20 IU/mL). HBV suppression rate was higher in HIV-virally suppressed patients than those with unsuppressed HIV viral load (p<0.001). In addition, the male sex was more likely to have unsuppressed HBV DNA (aOR 1.17, 95% CI: 1.17 to 3.21; p=0.010).ConclusionsWe reported a high prevalence of HBsAg seropositivity and low HBV immunisation coverage in people living with HIV in Sierra Leone. In addition, we observed that ART can efficiently result in a viral suppression rate of HBV infection. Therefore, achieving the global target of eliminating HBV infection by 2030 requires accelerated access to care for people living with HIV and HBV, including HBV testing, antiviral treatment and hepatitis B vaccination.
STRIKE-HBV: establishing an HBV screening programme in Kilifi, Kenya—challenges, successes and lessons learnt
Authors: Downs Louise O , Chirro Oscar , Zaharani Mwanakombo , Safari Benson , Okanda Dorcas , Githinji George , Andersson Monique I , Newton Rob , Etyang Anthony , Aliyan Nadia , Matthews Philippa Clare 
Published: May 2024

ObjectivesChronic hepatitis B infection affects 65 million people in the WHO African Region, but only 4.2% of these are diagnosed and 0.2% on treatment. Here, we present a short report describing establishment of a hepatitis B virus (HBV) programme in Kenya. We share experiences, successes and challenges to support development of future programmes.MethodsFrom March 2023, we began the ‘STRIKE-HBV’ Study to identify people living with HBV (PLWHB) in Kilifi, Kenya. We employed local staff and provided education and training. Individuals were identified through three routes: (1) we offered free-of-charge HBV testing for all non-pregnant adults attending Kilifi Country Hospital (KCH) outpatient department; (2) we invited PLWHB to reattend for review; and (3) we invited close contacts of PLWHB for screening and vaccination if HBV was negative. All those seropositive for HBV were offered a comprehensive liver health assessment.ResultsWe have established a framework for HBV screening, assessment and linkage to care in Kilifi. Between March 2023 and March 2024, we collected data for 80 PLWHB, comprising (1) screening of 1862 people of whom 30 were seropositive, (2) enrolment of 38 people known to be living with HBV and (3) testing of 97 close contacts of PLWHB, of whom 12 were positive. Among a limited subset with elastography data, we identified 9 of 59 as having significant fibrosis, and a further 6 people had laboratory aspartate transaminase (AST) to platelet ratio index (APRI) scores in keeping with fibrosis. We encountered challenges including procurement delays for hepatitis B surface antigen testing kits and HBV vaccinations, and issues accessing liver elastography.ConclusionsHBV screening was well received by the Kilifi population, has identified people at risk of liver disease progression and is improving linkage to care and vaccination at KCH. Future HBV programmes in WHO Africa can build on this experience as we work to develop accessible, affordable and acceptable care pathways.
Ash fertilization increases long-term timber production in drained nitrogen-poor Scots pine peatlands
Authors: Hökkä Hannu , Ahtikoski Anssi , Sarkkola Sakari , Väänänen Päivi 
Published: May 2024

Wood ash fertilization remarkably increases tree growth and hence, carbon sequestration in drained boreal peatland forests, particularly in nitrogen (N)-rich Scots pine sites with limited phosphorus (P) and potassium (K). Because ash lacks N, N-deficient ombrotrophic and poor oligotrophic sites are generally considered unsuitable for ash fertilization. In this study, timber production was investigated in six field experiments in N-poor, drained Scots pine dominated peatlands in central Finland, where ash fertilization was applied 15–85 years earlier. Ash significantly increased tree growth in all the study sites. Unfertilized plots showed long-term average mean annual increment (MAI) of 2.01 m3·ha−1·a−1, whereas in fertilized plots MAI was 4.46 m3·ha−1·a−1. An analysis with nonlinear mixed effects model revealed a faster volume yield development and higher asymptote of the mean curve in fertilized plots. Higher amount of K in the ash significantly increased the response. Fertilizations were financially lucrative: on average, the break-even cost surpassed the ash fertilization cost (390 € ha−1) more than two-fold at 5% interest rate. The current nutrient status of fertilized trees was rather balanced. The results proved that the long-term growth response to ash fertilization in poor drained peatland sites is comparable to N-rich sites, but the response time is distinctively longer.
Theoretical MRCI + Q study on electronic structure and spectroscopic properties of the HX+(X = F, Cl, Br, I) cations
Authors: Zhang Xiaomei , Zhang Xueyao , Chen Fanfan , Zhou Xiaohui , Liu Yufang 
Published: May 2024

In this work, we have systematacially investigated the electronic structure and spectroscopic properties of the HX+ (X = F, Cl, Br, I) cations by using the highly correlated MRCI + Q approach. This is the first comprehensive ab initio study on the electronic states of the HX+ cations. The spin–orbit coupling (SOC) effect is introduced with the state interaction approach. There are total 10 Λ-S and 18 Ω states obtained in the calculation. The results show that the potential energy curves’ (PECs) shapes and structure of the electronic states of different HX+ cations exhibit the significant distinction due to the X-dependent energy-level order of the unique dissociation channel H+(1Sg) + X(2Pu). From PECs, the spectroscopic constants of the bound electronic states are determined, which are in good agreement with available observed values. Regarding HBr+ and HI+, the good agreement has been achieved only when the SOC effect is considered. The predissociation for the first excited A2Σ+ state of HCl+, HBr+, and HI+ is analyzed based on computed spin–orbit matrix elements. Around the equilibrium position, the energy splittings of X2Π are calculated to be 288, 661, 2691, and 5137 cm−1 for HF+, HCl+, HBr+, and HI+, respectively. It has been demonstrated that SOC is substantial for HX+, leading to significant changes in PECs’ shapes as well as in electronic structure. Finally, the transition properties are predicted, including transition dipole moments, Franck–Condon factors, and radiative lifetimes. Both the Ω transitions A2Σ+ 1/2-X2Π3/2 and A2Σ+ 1/2-X2Π1/2 of the HX+ cations are determined to possess the radiative lifetimes at the microsecond (µs) level.
Testing space-time non-commutativity with TianQin
Authors: Huang Zeyu , Shi Changfu , Lyu Xiangyu , Mei Jianwei 
Published: May 2024

AbstractThe direct detection of gravitational waves offers a powerful tool to explore the nature of gravity and the structure of space-time. This paper focuses on the capabilities of space-based gravitational wave detectors in testing space-time non-commutativity. Our findings indicate that TianQin has the potential to impose constraints on the non-commutative scale at a sub-Planckian level using massive black hole binaries. Additionally, we have developed a pipeline tailored to this specific topic.
Nmssm with correct relic density and an additional 95 GeV Higgs boson
Authors: Ellwanger Ulrich , Hugonie Cyril 
Published: May 2024

AbstractWe investigate whether it is possible within the NMSSM to describe simultaneously a correct dark matter relic density complying with the latest null results from the LZ experiment, an extra Higgs boson with a mass of $$\sim 95$$

∼
95

GeV visible in the bb channel at LEP and the diphoton channel at the LHC, and the deviation of the anomalous magnetic moment of the muon from its value within the Standard Model. We find that this is still possible for a variety of dark matter annihilation mechanisms, for singlino-like but also bino-like lightest supersymmetric particles. We show the signal rates of the extra Higgs boson and the dark matter detection rates as function of the dark matter mass and annihilation mechanism. The dark matter direct detection cross section may well fall below the neutrino floor. The masses of the lightest electroweakly interacting supersymmetric particles are typically not far above 100 GeV, but not excluded due to unconventional decays.
Hepatitis B Virus X Protein Represses Expression of Tumor Suppressor PTPN18 in Hepatocellular Carcinoma
Authors: Zhou Zhenyu , Yu Wei , Li Huoming , Shi Juanyi , Meng Shiyu , Yan Yongcong , Chen Ruibin , Liu Haohan , Wang Jie , Sun Jian , Xiao Zhiyu , Zhang Jianlong 
Published: May 2024

Abstract
HBV-associated hepatocellular carcinoma (HCC) represents the prevalent form of HCC, with HBx protein being a crucial oncoprotein. Numerous members of the protein tyrosine phosphatase nonreceptor (PTPN) family have been confirmed to be significantly associated with the occurrence and progression of malignant tumors. Our group previously identified the involvement of PTPN13 in HCC. However, the roles of other PTPNs in HCC require further investigation. In this study, we found that PTPN18 expression was significantly downregulated within HCC tissues compared with adjacent nontumor and reference liver tissues. Functionally, PTPN18 exerted inhibitory effects on the proliferation, migration, invasion, and sphere-forming capability of HCC cells while concurrently promoting apoptotic processes. Through phospho-protein microarray screening followed by subsequent validation experiments, we identified that PTPN18 could activate the p53 signaling pathway and suppress the AKT/FOXO1 signaling cascade in HCC cells. Moreover, the HBx protein mediated the repression of PTPN18 expression by upregulating miR-128-3p. Collectively, our study unveiled the role of PTPN18 as a tumor suppressor in HBV-related HCC.
Implications: Our findings revealed that PTPN18 might be a potential diagnostic and therapeutic target for HBV-related HCC.
Lung Microbiome in Lung Cancer: A New Horizon in Cancer Study
Authors: Kashyap Pragya , Dutt Naveen , Ahirwar Dinesh K. , Yadav Pankaj 
Published: May 2024

Abstract
Lung cancer is the second most prevalent cancer worldwide and a leading cause of cancer-related deaths. Recent technological advancements have revealed that the lung microbiome, previously thought to be sterile, is host to various microorganisms. The association between the lung microbiome and lung cancer initiation, progression, and metastasis is complex and contradictory. However, disruption in the homeostasis of microbiome compositions correlated with the increased risk of lung cancer. This review summarizes current knowledge about the most recent developments and trends in lung cancer–related microbiota or microbial components. This article aims to provide information on this rapidly evolving field while giving context to the general role of the lung microbiome in lung cancer. In addition, this review briefly discussed the causative association of lung microbiome with lung cancer. We will review the mechanisms by which lung microbiota influence carcinogenesis, focusing on microbiota dysbiosis. Moreover, we will also discuss the host–microbiome interaction as it plays a crucial role in stimulating and regulating the immune response. Finally, we will provide information on the diagnostic role of the microbiome in lung cancer. This article aims to offer an overview of the lung microbiome as a predictive and diagnostic biomarker in lung cancer.
Three-Year Outcomes With Fractional Flow Reserve–Guided or Angiography-Guided Multivessel Percutaneous Coronary Intervention for Myocardial Infarction
Authors: Puymirat Etienne , Cayla Guillaume , Simon Tabassome , Steg Philippe Gabriel , Montalescot Gilles , Durand-Zaleski Isabelle , Ngaleu Siaha Fabiola , Gallet Romain , Khalife Khalife , Morelle Jean-François , Motreff Pascal , Lemesle Gilles , Dillinger Jean-Guillaume , Lhermusier Thibault , Silvain Johanne , Roule Vincent , Labèque Jean-Noel , Rangé Grégoire , Ducrocq Grégory , Cottin Yves , Blanchard Didier , Charles Nelson Anaïs , Djadi-Prat Juliette , Chatellier Gilles , Danchin Nicolas ,   for the FLOWER-MI Study Investigators
Published: May 2024

BACKGROUND:
In patients with multivessel disease with successful primary percutaneous coronary intervention for ST-segment–elevation myocardial infarction, the FLOWER-MI trial (Flow Evaluation to Guide Revascularization in Multivessel ST-Elevation Myocardial Infarction) showed that a fractional flow reserve (FFR)–guided strategy was not superior to an angiography-guided strategy for treatment of noninfarct-related artery lesions regarding the 1-year risk of death from any cause, myocardial infarction, or unplanned hospitalization leading to urgent revascularization. The extension phase of the trial was planned using the same primary outcome to determine whether a difference in outcomes would be observed with a longer follow-up.

METHODS:
In this multicenter trial, we randomly assigned patients with ST-segment–elevation myocardial infarction and multivessel disease with successful percutaneous coronary intervention of the infarct-related artery to receive complete revascularization guided by either FFR (n=586) or angiography (n=577).

RESULTS:

After 3 years, a primary outcome event occurred in 52 of 498 patients (9.40%) in the FFR-guided group and in 44 of 502 patients (8.17%) in the angiography-guided group (hazard ratio, 1.19 [95% CI, 0.79–1.77];
P
=0.4). Death occurred in 22 patients (4.00%) in the FFR-guided group and in 23 (4.32%) in the angiography-guided group (hazard ratio, 0.96 [95% CI, 0.53–1.71]); nonfatal myocardial infarction in 23 (4.13%) and 14 (2.56%), respectively (hazard ratio, 1.63 [95% CI, 0.84–3.16]); and unplanned hospitalization leading to urgent revascularization in 21 (3.83%) and 18 (3.36%; hazard ratio, 1.15 [95% CI, 0.61–2.16]), respectively.

CONCLUSIONS:
Although event rates in the trial were lower than expected, in patients with ST-segment–elevation myocardial infarction undergoing complete revascularization, an FFR-guided strategy did not have a significant benefit over an angiography-guided strategy with respect to the risk of death, myocardial infarction, or urgent revascularization up to 3 years.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02943954.
Mapping the Ecological Terrain of Stroke Prehospital Delay: A Nationwide Registry Study
Authors: Dhand Amar , Reeves Mathew J. , Mu Yi , Rosner Bernard A. , Rothfeld-Wehrwein Zachary R. , Nieves Amber , Dhongade Vrushali A. , Jarman Molly , Bergmark Regan W. , Semco Robert S. , Ader Jeremy , Marshall Brandon D.L. , Goedel William C. , Fonarow Gregg C. , Smith Eric E. , Saver Jeffrey L. , Schwamm Lee H. , Sheth Kevin N. 
Published: May 2024

BACKGROUND:
Delays in hospital presentation limit access to acute stroke treatments. While prior research has focused on patient-level factors, broader ecological and social determinants have not been well studied. We aimed to create a geospatial map of prehospital delay and examine the role of community-level social vulnerability.

METHODS:
We studied patients with ischemic stroke who arrived by emergency medical services in 2015 to 2017 from the American Heart Association Get With The Guidelines-Stroke registry. The primary outcome was time to hospital arrival after stroke (in minutes), beginning at last known well in most cases. Using Geographic Information System mapping, we displayed the geography of delay. We then used Cox proportional hazard models to study the relationship between community-level factors and arrival time (adjusted hazard ratios [aHR] <1.0 indicate delay). The primary exposure was the social vulnerability index (SVI), a metric of social vulnerability for every ZIP Code Tabulation Area ranging from 0.0 to 1.0.

RESULTS:
Of 750 336 patients, 149 145 met inclusion criteria. The mean age was 73 years, and 51% were female. The median time to hospital arrival was 140 minutes (Q1: 60 minutes, Q3: 458 minutes). The geospatial map revealed that many zones of delay overlapped with socially vulnerable areas (https://harvard-cga.maps.arcgis.com/apps/webappviewer/index.html?id=08f6e885c71b457f83cefc71013bcaa7). Cox models (aHR, 95% CI) confirmed that higher SVI, including quartiles 3 (aHR, 0.96 [95% CI, 0.93–0.98]) and 4 (aHR, 0.93 [95% CI, 0.91–0.95]), was associated with delay. Patients from SVI quartile 4 neighborhoods arrived 15.6 minutes [15–16.2] slower than patients from SVI quartile 1. Specific SVI themes associated with delay were a community’s socioeconomic status (aHR, 0.80 [95% CI, 0.74–0.85]) and housing type and transportation (aHR, 0.89 [95% CI, 0.84–0.94]).

CONCLUSIONS:
This map of acute stroke presentation times shows areas with a high incidence of delay. Increased social vulnerability characterizes these areas. Such places should be systematically targeted to improve population-level stroke presentation times.
Learning Islam through the Senses
Authors: Flaskerud Ingvild 
Published: May 2024

Abstract
This article discusses how the visual and embodied storytelling methods of the theater may be used in the formation of Islamic knowledge. Examining productions staged by young women in Oslo in the tradition of the Twelver Shia theater, taʿziyeh/shabih, during commemorative rituals, I ask: How did producers and actors perceive theater to generate knowledge? How were visual and embodied storytelling methods used in conveying religious knowledge? What kind of knowledge was generated? Inspired by theater theory and post-structuralist semiotics, the analysis shows that the theater had transformative qualities that could contribute to cultural transmission, education, and moral and spiritual development. Knowledge was produced through sensorial communication, thinking, and understanding, and was held to emerge from the spectators’ and actors’ aesthetic and affective experiences, in addition to their abilities to create emotional relations with holy protagonists and the divine. The learning outcome was therefore presented as open-ended and invited young spectators and actors to take responsibility and reflect on how to act and respond in our time.