bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parallel Chords: an audio-visual analytics design for parallel coordinates
Authors: Elmquist Elias , Enge Kajetan , Rind Alexander , Navarra Carlo , Höldrich Robert , Iber Michael , Bock Alexander , Ynnerman Anders , Aigner Wolfgang , Rönnberg Niklas 
Published: May 2024

AbstractOne of the commonly used visualization techniques for multivariate data is the parallel coordinates plot. It provides users with a visual overview of multivariate data and the possibility to interactively explore it. While pattern recognition is a strength of the human visual system, it is also a strength of the auditory system. Inspired by the integration of the visual and auditory perception in everyday life, we introduce an audio-visual analytics design named Parallel Chords combining both visual and auditory displays. Parallel Chords lets users explore multivariate data using both visualization and sonification through the interaction with the axes of a parallel coordinates plot. To illustrate the potential of the design, we present (1) prototypical data patterns where the sonification helps with the identification of correlations, clusters, and outliers, (2) a usage scenario showing the sonification of data from non-adjacent axes, and (3) a controlled experiment on the sensitivity thresholds of participants when distinguishing the strength of correlations. During this controlled experiment, 35 participants used three different display types, the visualization, the sonification, and the combination of these, to identify the strongest out of three correlations. The results show that all three display types enabled the participants to identify the strongest correlation — with visualization resulting in the best sensitivity. The sonification resulted in sensitivities that were independent from the type of displayed correlation, and the combination resulted in increased enjoyability during usage.
In-vitro effects of novel periodontal scalers with a planar ultrasonic piezoelectric transducer on periodontal biofilm removal, dentine surface roughness, and periodontal ligament fibroblasts adhesion
Authors: Berto Luciana Aranha , Ettmayer Johanna Blanda , Stutzer Diego , Nietzsche Sandor , Niederhauser Thomas , Burger Juergen , Sculean Anton , Eick Sigrun , Hofmann Martin 
Published: May 2024

Abstract
Objectives
To compare ultrasonic scaler prototypes based on a planar piezoelectric transducer with different working frequencies featuring a titanium (Ti-20, Ti-28, and Ti-40) or stainless steel (SS-28) instrument, with a commercially available scaler (com-29) in terms of biofilm removal and reformation, dentine surface roughness and adhesion of periodontal fibroblasts.

Materials and methods
A periodontal multi-species biofilm was formed on specimens with dentine slices. Thereafter specimens were instrumented with scalers in a periodontal pocket model or left untreated (control). The remaining biofilms were quantified and allowed to reform on instrumented dentine slices. In addition, fibroblasts were seeded for attachment evaluation after 72 h of incubation. Dentine surface roughness was analyzed before and after instrumentation.

Results
All tested instruments reduced the colony-forming unit (cfu) counts by about 3 to 4 log10 and the biofilm quantity (each p < 0.01 vs. control), but with no statistically significant difference between the instrumented groups. After 24-hour biofilm reformation, no differences in cfu counts were observed between any groups, but the biofilm quantity was about 50% in all instrumented groups compared to the control. The attachment of fibroblasts on instrumented dentine was significantly higher than on untreated dentine (p < 0.05), with the exception of Ti-20. The dentine surface roughness was not affected by any instrumentation.

Conclusions
The planar piezoelectric scaler prototypes are able to efficiently remove biofilm without dentine surface alterations, regardless of the operating frequency or instrument material.

Clinical relevance
Ultrasonic scalers based on a planar piezoelectric transducer might be an alternative to currently available ultrasonic scalers.
Pulsed electromagnetic fields (PEMF) as a valid tool in orthognathic surgery to reduce post-operative pain and swelling: a prospective study
Authors: Friscia Marco , Abbate Vincenzo , De Fazio Gianluca Renato , Sani Lorenzo , Spinelli Raffaele , Troise Stefania , Bonavolontà Paola , Committeri Umberto , Califano Luigi , Orabona Giovanni Dell’Aversana 
Published: May 2024

Abstract
Purpose
PEMF (pulsed electromagnetic fields) founds application in several medical fields to accelerate bone wounds healing and to reduce inflammation. The aim of our study was to evaluate the effectiveness of PEMF in reducing postoperative swelling and pain in patients undergoing orthognathic surgery.

Methods
A prospective observational monocentric study was conducted on a sample of 30 patients undergone to orthognathic surgery in Maxillofacial Surgery Unit of University of Naples Federico II. The patients who followed these inclusion criteria were enrolled in the study: age ≥ 18 years, Class III malocclusion, Surgical procedure of Le Fort I osteotomy + Bilateral Sagittal Split Osteotomy (BSSO), Written informed consent. Patients were divided into two groups: Group SD) postoperative standard treatment with medical therapy and cryotherapy, Group SD + PEMF) postoperative standard therapy + PEMF. Each patient underwent a 3D facial scan, at one (1d) and four (4d) days after surgery to compare the swelling reduction. The pain score was assessed through VAS score and analgesics administration amount.

Results
In SD + PEMF group, the facial volume reduction between 1d and 4d scan was on average 56.2 ml (6.23%), while in SD group, it was 23.6 ml (2.63%). The difference between the two groups was 3.6% (p = 0.0168). VAS pain values were significantly higher in SD group compared to SD + PEMF group in the second day after surgery (P = 0.021) and in the total 4 days (P = 0.008).

Conclusions
Our data suggest that PEMF is valid tool to promote faster postoperative swelling and pain reduction in patients undergoing orthognathic surgery.
Deleterious effects of the endosymbiont Rickettsiella viridis in Myzus persicae are environmentally dependent
Authors: Ross Perran A. , Tyrilos Michail C. , Durugkar Neha , Gill Alex , de Jonge Nadieh , Yang Qiong , Gu Xinyue , Hoffmann Ary A. , Kristensen Torsten N. 
Published: May 2024

AbstractEndosymbionts living within insect cells can modify host fitness and could provide new tools for pest control. The endosymbiont Rickettsiella viridis has been transferred experimentally into the green peach aphid, Myzus persicae, a globally important agricultural pest. This Rickettsiella spreads via vertical and horizontal transmission and induces host fitness costs which could potentially suppress pest populations. Endosymbiont prevalence can fluctuate in natural populations, and it is important to identify factors that contribute to their spread or loss. Here, we explore the effects of Rickettsiella infection when aphids are reared on eight different host plants or exposed to thermal, starvation and desiccation stresses. Rickettsiella infection reduced M. persicae fecundity and longevity across all host plants, but the magnitude of costs varied among host plants and generations. Rickettsiella was horizontally transmitted and spread in caged populations at initial ratios of 1:2 Rickettsiella (+): Rickettsiella (−) on all host plants, but with limited long-term persistence under cycling 20–30 °C. We also identified temperature-dependent costs of Rickettsiella infection on heat knockdown time, chill coma recovery, and starvation tolerance. Finally, we present evidence that Rickettsiella infection reduces host activity levels under heat stress. Our results suggest that Rickettsiella infections induce a variety of deleterious effects but with complex environment-dependent interactions. This work helps understand ecological conditions that enhance or limit the spread of these endosymbionts in aphid populations.
Impact of Tissue Damage and Hemodynamics on Restenosis Following Percutaneous Transluminal Angioplasty: A Patient-Specific Multiscale Model
Authors: Corti Anna , Marradi Matilde , Çelikbudak Orhon Cemre , Boccafoschi Francesca , Büchler Philippe , Rodriguez Matas Jose F. , Chiastra Claudio 
Published: May 2024

AbstractMultiscale agent-based modeling frameworks have recently emerged as promising mechanobiological models to capture the interplay between biomechanical forces, cellular behavior, and molecular pathways underlying restenosis following percutaneous transluminal angioplasty (PTA). However, their applications are mainly limited to idealized scenarios. Herein, a multiscale agent-based modeling framework for investigating restenosis following PTA in a patient-specific superficial femoral artery (SFA) is proposed. The framework replicates the 2-month arterial wall remodeling in response to the PTA-induced injury and altered hemodynamics, by combining three modules: (i) the PTA module, consisting in a finite element structural mechanics simulation of PTA, featuring anisotropic hyperelastic material models coupled with a damage formulation for fibrous soft tissue and the element deletion strategy, providing the arterial wall damage and post-intervention configuration, (ii) the hemodynamics module, quantifying the post-intervention hemodynamics through computational fluid dynamics simulations, and (iii) the tissue remodeling module, based on an agent-based model of cellular dynamics. Two scenarios were explored, considering balloon expansion diameters of 5.2 and 6.2 mm. The framework captured PTA-induced arterial tissue lacerations and the post-PTA arterial wall remodeling. This remodeling process involved rapid cellular migration to the PTA-damaged regions, exacerbated cell proliferation and extracellular matrix production, resulting in lumen area reduction up to 1-month follow-up. After this initial reduction, the growth stabilized, due to the resolution of the inflammatory state and changes in hemodynamics. The similarity of the obtained results to clinical observations in treated SFAs suggests the potential of the framework for capturing patient-specific mechanobiological events occurring after PTA intervention.
Use of ultrasound and MRI to stage the axilla for breast cancer before and after neoadjuvant chemotherapy prior to targeted sentinel lymphadenectomy
Authors: Brabender Danielle , Ballard April , Kim Sean , Hovanessian-Larsen Linda , Sener Stephen F. 
Published: May 2024

Abstract
Purpose
Prior data from this Center demonstrated that for patients who had biopsy-proven axillary metastases, were ycN0 after neoadjuvant chemotherapy (NAC), and had a wire-directed (targeted) sentinel lymphadenectomy (WD-SLND), 60% were node negative. The hypothesis of this study was that results of axillary imaging either before or after NAC would be predictive of final pathologic status after WD-SLND.

Methods
For patients treated with NAC between 2015 and 2023, ultrasound and MRI images of the axilla were retrospectively reviewed by radiologists specializing in breast imaging, who were blinded to the surgical and pathology results.

Results
Of 113 patients who fit the clinical criteria, 66 (58%) were ypN0 at WD-SLND and 34 (30%) had a pathologic complete response to NAC. There was no correlation between the number of abnormal lymph nodes on pre-NAC ultrasound or MRI imaging and the final pathologic status of the lymph nodes. The positive predictive value (PPV) of abnormal post-NAC axillary imaging was 48% for ultrasound and 53% for MRI. The negative predictive value (NPV) for normal post-NAC axillary imaging was 67% for ultrasound and 68% for MRI.

Conclusion
The results of axillary imaging were not adequate to identify lymph nodes after NAC that were persistently pathologically node positive or those which had become pathologically node negative.
Exosomal YB-1 facilitates ovarian restoration by MALAT1/miR-211-5p/FOXO3 axis
Authors: Zhang Mengxue , Xing Jie , Zhao Shijie , Lu Minjun , Liu Yueqin , Lin Li , Gao Wujiang , Chen Lu , Li Wenxin , Shang Junyu , Zhou Jiamin , Yin Xinming , Zhu Xiaolan 
Published: May 2024

AbstractPremature ovarian failure (POF) affects many adult women less than 40 years of age and leads to infertility. Mesenchymal stem cells-derived small extracellular vesicles (MSCs-sEVs) are attractive candidates for ovarian function restoration and folliculogenesis for POF due to their safety and efficacy, however, the key mediator in MSCs-sEVs that modulates this response and underlying mechanisms remains elusive. Herein, we reported that YB-1 protein was markedly downregulated in vitro and in vivo models of POF induced with H2O2 and CTX respectively, accompanied by granulosa cells (GCs) senescence phenotype. Notably, BMSCs-sEVs transplantation upregulated YB-1, attenuated oxidative damage-induced cellular senescence in GCs, and significantly improved the ovarian function of POF rats, but that was reversed by YB-1 depletion. Moreover, YB-1 showed an obvious decline in serum and GCs in POF patients. Mechanistically, YB-1 as an RNA-binding protein (RBP) physically interacted with a long non-coding RNA, MALAT1, and increased its stability, further, MALAT1 acted as a competing endogenous RNA (ceRNA) to elevate FOXO3 levels by sequestering miR-211-5p to prevent its degradation, leading to repair of ovarian function. In summary, we demonstrated that BMSCs-sEVs improve ovarian function by releasing YB-1, which mediates MALAT1/miR-211-5p/FOXO3 axis regulation, providing a possible therapeutic target for patients with POF.
Full-Scale Fire Experiments on Cross-Laminated Timber Residential Enclosures Featuring Different Lining Protection Configurations
Authors: Hopkin Danny , Węgrzyński Wojciech , Gorska Carmen , Spearpoint Michael , Bielawski Jakub , Krenn Harald , Sleik Tim , Blondeau Renaud , Stapf Gordian 
Published: May 2024

AbstractThe adoption of timber, specifically cross-laminated timber (CLT), as a primary construction material is gaining traction due to its carbon sequestration capabilities, environmental advantages, and potential for precision manufacturing. However, the combustibility of wood raises legitimate concerns about fire safety in timber-based residential buildings. This paper investigates the fire performance of timber in a residential context, attempting to fill knowledge gaps and outline strategies for improving fire robustness in timber-built dwellings. Through comprehensive experimental studies on residential-type enclosures constructed with CLT panels, this research explores different configurations and the effects of varying degrees of non-combustible protective lining. The findings underscore the significance of considering timber surface exposure and adopting effective encapsulation strategies in CLT buildings. It has been estimated that the exposure of timber walls leads to a proportional increase in heat release rate, corresponding to the area of exposed timber surfaces and their charring rates. Consequently, the external flame has a larger projection, resulting in a much greater heat flux to the façade. Furthermore, threshold conditions for initial flaming self-extinguishment of timber defined in literature of 44.5 ± 1.2 kW/m2 have been found to be applicable to the experiments conducted in this research. Finally, it has been observed that partial encapsulation, where the protective lining will likely fall off during a fire, may hinder rather than increase the likelihood of self-extinguishment. This work contributes towards a nuanced understanding of fire dynamics in timber structures, offering insights for safer and more effective design strategies for CLT-based construction.
Temperedness of locally symmetric spaces: the product case
Authors: Weich Tobias , Wolf Lasse L. 
Published: May 2024

AbstractLet $$X=X_1\times X_2$$

X
=

X
1

×

X
2

be a product of two rank one symmetric spaces of non-compact type and $$\Gamma $$
Γ
a torsion-free discrete subgroup in $$G_1\times G_2$$

G
1

×

G
2

. We show that the spectrum of $$\Gamma \backslash (X_1\times X_2)$$

Γ
\
(

X
1

×

X
2

)

is related to the asymptotic growth of $$\Gamma $$
Γ
in the two directions defined by the two factors. We obtain that $$L^2(\Gamma \backslash (G_1 \times G_2))$$

L
2

(
Γ
\

(

G
1

×

G
2

)

)

is tempered for a large class of $$\Gamma $$
Γ
.
Targeted Demethylation of FOXP3-TSDR Enhances the Suppressive Capacity of STAT6-deficient Inducible T Regulatory Cells
Authors: Arroyo-Olarte Rubén D. , Flores-Castelán Juan C. , Armas-López Leonel , Escobedo Galileo , Terrazas Luis I. , Ávila-Moreno Federico , Leon-Cabrera Sonia 
Published: May 2024

AbstractIn vitro induced T regulatory cells (iTregs) are promising for addressing inflammation-driven diseases. However, current protocols for the generation and expansion of iTregs fail to induce extensive demethylation of the Treg-specific demethylated region (TSDR) within the FOXP3 gene, recognized as the master regulator for regulatory T cells (Tregs). This deficiency results in the rapid loss of Foxp3 expression and an unstable regulatory phenotype. Nevertheless, inhibition of STAT6 signaling effectively stabilizes Foxp3 expression in iTregs. Thus, this study aimed to develop a protocol combining epigenetic editing with STAT6 deficiency to improve iTregs’ ability to maintain stable suppressive function and a functional phenotype. Our findings demonstrate that the combination of STAT6 deficiency (STAT6-/-) with targeted demethylation of the TSDR using a CRISPR-TET1 tool leads to extensive demethylation of FOXP3-TSDR. Demethylation in STAT6-/- iTregs was associated with enhanced expression of Foxp3 and suppressive markers such as CTLA-4, PD-1, IL-10, and TGF-β. Furthermore, the edited STAT6-/- iTregs exhibited an increased capacity to suppress CD8+ and CD4+ lymphocytes and could more efficiently impair Th1-signature gene expression compared to conventional iTregs. In conclusion, the deactivation of STAT6 and TSDR-targeted demethylation via CRISPR-TET1 is sufficient to induce iTregs with heightened stability and increased suppressive capacity, offering potential applications against inflammatory and autoimmune diseases.
Formative Evaluation of an Interactive Personalised Learning Technology to Inform Equitable Access and Inclusive Education for Children with Special Educational Needs and Disabilities
Authors: Layachi Aida , Pitchford Nicola J. 
Published: May 2024

AbstractIn accordance with the 2030 Sustainable Development Goal for Education, to promote equitable access and inclusive education for all, it is critical to explore if educational technologies can be used effectively by children with Special Educational Needs and Disabilities (SEND). It has been argued that educational technologies need to be tailored to the individual needs of children with SEND, otherwise they can create new layers of exclusion at school. The aim of this study was to examine the suitability of an interactive, personalised, educational technology, designed to support the learning of foundational skills, that is being introduced in several countries worldwide, for use by children with SEND. A participatory formative evaluation was conducted with ten academic experts in SEND. Each expert interacted with the technology individually, then gave written feedback through a semi-structured review form, before engaging with the other experts in an online group discussion. Qualitative data were analysed by reflexive thematic analysis. Six themes emerged pertaining to the strengths of the educational technology and areas of weakness where improvements are needed to support children with vision impairment, hearing, and functional difficulties through recommended hardware, and software updates, and by considering how the technology could be used to boost children’s motivation, and the role of the teacher in supporting children with SEND to use the technology effectively. Implications for instructional design decisions, based on research evidence, are considered for promoting equitable access and inclusive education for children with SEND through technology-supported personalised learning platforms.
Definition of Design Space for Preparation and Stability of Tramadol Hydrochloride Loaded Nanoparticles Using OFAT Experiments for Infusion in Pain Management
Authors: Yildirim Nuray , Savaser Ayhan , Esim Ozgur , Topal Gizem Ruya , Kose Ozkan Cansel , Ozkan Yalcin 
Published: May 2024

AbstractThis paper presents an experimental study on preparation of tramadol hydrochloride (TrH) loaded nanoparticles, and stability determination in various infusion solutions. In this study, various nanoparticle preparation parameters based on w/o/w emulsification solvent evaporation method, including stabilizer type, stabilizer concentration, polymer concentration, homogenization speed and initial drug amount were systematically tested to verify their versatility for preparing nanoparticles. Initially both particle size and encapsulation efficiency of nanoparticles were changed significantly with the change in surfactant and polymer ratio (p<0.05). However, homogenization speed only changed particle size (average size 339.3±1.8 nm for 15000 rpm, 318.9±6.4 nm for 20000 rpm and 237.2±7.8 nm for 25000 rpm) (p<0.05) and initial drug concentration is only affected the encapsulation efficiency (34.2±0.7% for 4 mg/mL and 33.2±0.9 for 1.6 mg/mL) (p<0.05). Storage at room temperature for 3 months resulted in an increase in particle size and polydispersity index. Prepared nanoparticles showed the best stability after storage at – 20 °C for in 3 months. Finally, storage of nanoparticles in various infusion solutions resulted an undesirable changes for 6% Hydroxyethyl starch in 0.9% sodium chloride injection, 10% Dextran 40 and 4% Succinyl gelatin solutions. It was shown that an appropriate delivery of TrH loaded PLGA nanoparticles as infusion can be prepared only in water for injection, 20% Mannitol, 0.9% Sodium chloride and 5% Dextrose solutions.
Secure renting by living collectively? A relational exploration of home and homemaking in rental housing cooperatives
Authors: Guity-Zapata Nestor Agustin , Stone Wendy M. , Nygaard Christian A. 
Published: May 2024

AbstractIn many countries, rental housing is associated with insecure occupant rights and limited control for residents and homeownership is linked with ontological security. In the literature on homemaking, ontological security comprises a set of attributes, i.e., secure occupancy, autonomy and control, but these are often bundled, or treated jointly. In this paper we draw on the lived experiences of residents in Rental Housing Cooperatives (RHC) in Honduras and Australia, and ask how the experience of ontological security in RHC is shaped by its distinct characteristics? We argue that, if the experience of ontological security can be ‘unbundled’, wellbeing in rental housing, particularly for population groups increasingly locked out of homeownerships, can be advanced through housing policy innovation that enhances these, or specific, attributes of ontological security. Methodologically the paper draws on relational thinking, interview data (n = 15) and qualitative analysis of homemaking practices within RHC in Honduras and Australia. The paper utilises a four-quadrant qualitative assessment framework for evaluating occupants’ sense of security and autonomy/control, relative to their sense of home and simply being housed. Our results suggest that secure occupancy more fundamentally underpins a sense of home, than autonomy/control. Implications for rental policy and research are considered.