bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insensitive Investors
Authors: CHARLES CONSTANTIN , FRYDMAN CARY , KILIC METE 
Published: June 2024

ABSTRACTWe experimentally study the transmission of subjective expectations into actions. Subjects in our experiment report valuations that are far too insensitive to their expectations, relative to the prediction from a frictionless model. We propose that the insensitivity is driven by a noisy cognitive process that prevents subjects from precisely computing asset valuations. The empirical link between subjective expectations and actions becomes stronger as subjective expectations approach rational expectations. Our results highlight the importance of incorporating weak transmission into belief‐based asset pricing models. Finally, we discuss how cognitive noise can provide a microfoundation for inelastic demand in the stock market.
Balancing Variety and Quality: Examining the Impact of Benefit‐Linked Cross‐Subsidization on Multisided Platforms
Authors: Tavalaei M. Mahdi , Santaló Juan , Gawer Annabelle 
Published: June 2024

AbstractMultisided platforms face a fundamental trade‐off: should they ease entry for a larger number of providers of complementary products or services (complementors) to join the platform and benefit from cross‐side network externalities, or should they limit entry to maintain complementors’ incentives to provide high‐quality offerings? We contend that a specific cross‐subsidizing pricing strategy – where the amount of subsidy to complementors is explicitly linked to the overall revenue they generate on the other side of the platform – may mitigate this trade‐off. Using data from the airport industry, we demonstrate that following a reduction of airlines’ entry barriers, airports that subsidize airlines, based on the aforementioned scheme, can boost their financial performance and maintain traffic composition in favour of legacy airlines, which bring passengers who spend more in airport shops. Our findings shed light on how cross‐subsidization may balance the variety and quality of complementors and their offerings on multisided platforms.
Bending stories, disrupting boundaries: spatial reclamation as literacy practices beyond the rows and rules
Authors: Walker Amy , Pennington Casey M. 
Published: June 2024

AbstractIn this article, we explore the dynamic interplay of youth agency, spatial justice, and literacy practices across community spaces through micro‐analysis of photographs and interviews of children and youth. Through a lens of spatial reclamation, the study investigates how children and youth disrupt adult‐designed spaces to restory and reclaim narratives, ultimately reshaping the socio‐spatial landscape. Combining the concepts of restorying and spatial justice, we explore the awareness and agency children exhibit when challenging dominant expectations, particularly examining instances of rulebreaking and safety negotiation. Examining two distinct settings—a school playground and a community protest—the study reveals how youth engage in embodied performances that rupture anticipated discourses in place. The findings underscore the multilayered nature of youth rulebreaking as a form of resistance and as a form of leadership, emphasising the potential for transformative socio‐spatial impact as youth reclaim narratives through new co‐constructions of space. Across age groups and geographies, Black and Brown youth and children emerge as leaders in reshaping spaces through their acts of resistance, redefining boundaries, and leading peaceful protests. The article calls for a nuanced understanding of how spatial justice intersects with restorying, urging educators and researchers to reconsider acts of reclamation as literacies across adult‐dictated spaces.
Psychological Distress, Multicare Needs and Social Resource Utilisation of Family Caregivers of People With Dementia: A Descriptive‐Correlational Study
Authors: Shen Wan‐Ching , Chang Ling‐Hui , Huang Ying‐Che , Wang Jing‐Jy 
Published: June 2024

ABSTRACTBackgroundThe population of people with dementia increases yearly, imposing a growing burden on family caregivers. Psychological distress impacts the mental health of family caregivers of people with dementia. Caregiver psychological distress can result in increased social resource utilisation and unmet multicare needs.PurposeThe study explored the psychological distress of family caregivers of people with dementia and examined the impact on social resource utilisation and multicare needs.MethodsA descriptive‐correlational study collected data in Taiwan from a cross‐sectional sample of family caregivers of people with dementia using a self‐report questionnaire. Data were analysed using linear and logistic regression.ResultsA total of 301 caregivers provided data for analysis. Nearly two‐thirds of caregivers were female with a mean age of 57 years old (SD = 12). Over half of the family caregivers of people with dementia experienced mild‐to‐moderate psychological distress. The greater the psychological distress, the greater the probability of using social resources (1.09 times per 1‐point increase, p = 0.002). Psychological distress was positively associated with the number of caregivers' care needs (β = 0.371, p < 0.001).ConclusionsFindings of this study can assist healthcare professionals in better understanding the psychological distress and care needs of caregivers. Services designed to meet the needs of family caregivers will improve psychological distress.
Urban functional zone mapping by coupling domain knowledge graphs and high‐resolution satellite images
Authors: Chen Yixiang , Dang Xu , Zhu Daoyou , Huang Yi , Qin Kun 
Published: June 2024

AbstractTimely and accurate mapping of urban functional zones (UFZs) is crucial to urban planning and management. Although existing methods for identifying urban functions have made remarkable progress, they still suffer from limitations, such as high sample dependency, insufficient semantic relationship representation, and poor interpretability due to being data‐driven models. To bridge this gap between these methods and the way humans identify functional areas, a new framework that couples domain knowledge and remote sensing images was proposed for the mapping of UFZs. First, to model the concepts, attributes, and spatial and semantic relationships of urban functional objects, a UFZ knowledge graph (UFZ‐KG) was constructed to assist in the mapping of UFZs. Then, the contrastive language‐image pretraining model was adopted to encode jointly the semantic features of UFZ‐KG and the visual features of UFZ images. In this model, a nonlinear embedding module was designed to achieve semantic alignment of these two different modal features in shared space. The effectiveness of the proposed method was verified in three test areas in Shenzhen, China. Results demonstrate that the proposed method of coupling UFZ‐KG with satellite images significantly enhances the UFZ classification accuracy compared to the method that solely relies on image features. Furthermore, it exhibits good generalization performance.
What are the experiences of teleophthalmology in optometric referral pathways? A qualitative interview study with patients and clinicians
Authors: Patel Dilisha , Abdi Sarah , Carmichael Josie , Balaskas Konstantinos , Blandford Ann 
Published: June 2024

Objective
Implementing teleophthalmology into the optometric referral pathway may ease the current pressures on hospital eye services caused by over-referrals from some optometrists. This study aimed to understand the practical implications of implementing teleophthalmology by analysing lived experiences and perceptions of teleophthalmology in the optometric referral pathway for suspected retinal conditions.

Design
Qualitative in-depth interview study

Setting
Fourteen primary care optometry practices and four secondary care hospital eye services from four NHS Foundation Trusts across the UK.

Participants
We interviewed 41 participants: patients (17), optometrists (18), and ophthalmologists (6) who were involved in the HERMES study. Through thematic analysis, we collated and present their experiences of implementing teleophthalmology.

Results
All participants interviewed were positive towards teleophthalmology as it could enable efficiencies in the referral pathway and improve feedback and communication between patients and healthcare professionals. Concerns included setup costs for optometrists and anxieties from patients about not seeing an ophthalmologist face to face. However, reducing unnecessary visits and increasing the availability of resources and capacity were seen as significant benefits.

Conclusions
Overall, we report positive experiences of implementing teleophthalmology into the optometric referral pathway for suspected retinal conditions. Successful implementation will require appropriate investment to set up and integrate new technology and remunerate services, and continued evaluation to ensure timely feedback to patients and between healthcare professionals is received.

Trial registration number

nct18106677.
Understanding experiences, unmet needs and priorities related to post-stroke aphasia care: stage one of an experience-based co-design project
Authors: Anemaat Lisa N , Palmer Victoria J , Copland David A , Binge Geoffrey , Druery Kent , Druery Julia , Mainstone Kathryn , Aisthorpe Bruce , Mainstone Penelope , Burton Bridget , Wallace Sarah J 
Published: June 2024

Objective
People with post-stroke aphasia (language/communication impairment) and their supporters report mixed satisfaction with stroke and aphasia care. To date, however, their journey of care and the key service interactions that shape their experience have not been comprehensively explored. We aimed to investigate the lived experience of post-stroke aphasia care, across the continuum of care and by geographical location, to establish priorities for service design.

Design
This is the first stage of an experience-based co-design study. We purposively sampled people with aphasia (PWA) and significant others (SOs) across 21 hospital and health service sites, community groups and by self-referral. Participants shared experiences of care in online interviews and focus groups. Touchpoints (key moments that shape experience) and unmet needs were identified using qualitative thematic analysis. Priorities for service design were established using an adapted nominal group technique.

Setting
Sites spanned remote, regional and metropolitan areas in Queensland, Australia.

Participants
PWA (n=32; mild=56%; moderate=31%; severe=13%) and SOs (n=30) shared 124 experiences of acute, rehabilitation and community-based care in 23 focus groups and 13 interviews.

Results
Both positive and negative healthcare experiences occurred most frequently in hospital settings. Negative experiences regularly related to communication with health professionals, while positive experiences related to the interpersonal qualities of healthcare providers (eg, providing hope) for PWA, or witnessing good rapport between a PWA and their health professional for SOs. To improve services, PWA prioritised communicatively accessible education and information and SOs prioritised access to psychological and peer support.

Conclusions
We identified key aspects of post-stroke aphasia care that shape experience. The needs of PWA and SOs may be better met through health professional training in supported communication, increased service availability in regional and remote areas, communication-accessible hospital environments, increased access to psychological and peer support, and meaningful involvement of SOs in rehabilitation.
Propofol enhancement of slow wave sleep to target the nexus of geriatric depression and cognitive dysfunction: protocol for a phase I open label trial
Authors: Rios Rachel Lynn , Green Michael , Smith S Kendall , Kafashan MohammadMehdi , Ching ShiNung , Farber Nuri B , Lin Nan , Lucey Brendan P , Reynolds Charles F , Lenze Eric J , Palanca Ben Julian Agustin 
Published: June 2024

Introduction
Late-life treatment-resistant depression (LL-TRD) is common and increases risk for accelerated ageing and cognitive decline. Impaired sleep is common in LL-TRD and is a risk factor for cognitive decline. Slow wave sleep (SWS) has been implicated in key processes including synaptic plasticity and memory. A deficiency in SWS may be a core component of depression pathophysiology. The anaesthetic propofol can induce electroencephalographic (EEG) slow waves that resemble SWS. Propofol may enhance SWS and oral antidepressant therapy, but relationships are unclear. We hypothesise that propofol infusions will enhance SWS and improve depression in older adults with LL-TRD. This hypothesis has been supported by a recent small case series.

Methods and analysis
SWIPED (Slow Wave Induction by Propofol to Eliminate Depression) phase I is an ongoing open-label, single-arm trial that assesses the safety and feasibility of using propofol to enhance SWS in older adults with LL-TRD. The study is enrolling 15 English-speaking adults over age 60 with LL-TRD. Participants will receive two propofol infusions 2–6 days apart. Propofol infusions are individually titrated to maximise the expression of EEG slow waves. Preinfusion and postinfusion sleep architecture are evaluated through at-home overnight EEG recordings acquired using a wireless headband equipped with dry electrodes. Sleep EEG recordings are scored manually. Key EEG measures include sleep slow wave activity, SWS duration and delta sleep ratio. Longitudinal changes in depression, suicidality and anhedonia are assessed. Assessments are performed prior to the first infusion and up to 10 weeks after the second infusion. Cognitive ability is assessed at enrolment and approximately 3 weeks after the second infusion.

Ethics and dissemination
The study was approved by the Washington University Human Research Protection Office. Recruitment began in November 2022. Dissemination plans include presentations at scientific conferences, peer-reviewed publications and mass media. Positive results will lead to a larger phase II randomised placebo-controlled trial.

Trial registration number

NCT04680910.
Abstract PO-020: ZBTB24 is a novel tumor suppressor and cooperates with CDKN2A to suppress B-cell lymphomagenesis
Authors: Li Rongrong , Sheshadri Namratha , Shen Jianliang , Yan Junrong , Jung Jaeyong , Tariq Muhammad Usama , Wang Y Lynn , Xie Ping , Zong Wei-Xing 
Published: June 2024

Abstract
B-cell lymphoma is the most common hematological malignancy that accounts for the sixth highest mortality among all cancers. Despite recent improvements on combined chemotherapy and immunotherapy, treatments remain challenging due to complex genetic heterogeneity and molecular pathogenesis. To explore novel mechanisms in B-cell lymphomagenesis, we performed a genome-wide CRISPR knockout screen in the murine interleukin-3 (IL-3)-dependent Ba/F3 pro-B cell line and identified Zbtb24 as a putative target whose silencing leads to elevated proliferative signaling and reduced apoptosis, conferring IL-3-independent growth in Ba/F3 cells. Silencing of ZBTB24 also accelerated growth in multiple human B-cell lymphoma cell lines. ZBTB24 is a member of the zinc-finger and BTB domain containing transcription factor that is highly expressed in spleen and bone marrow. While it has been shown that ZBTB24 may play an important role in B-cell development and activation, its involvement in B-cell lymphoma has not been described. Analysis of publicly available datasets found that ZBTB24 copy number deletion occurs in various B-cell lymphomas, which frequently co-occurs with deletion of the tumor suppressor CDKN2A. Hence, we generated B-cell specific Zbtb24 single knockout and Zbtb24/Cdkn2a double knockout mice to explore the role of Zbtb24 in vivo. While Zbtb24 and Cdkn2a single knockout mice remained tumor-free or showed low penetrance of tumorigenesis, the double knockout mice developed lymphadenopathy and splenomegaly accompanied with accelerated mortality. Flow cytometry analysis of bone marrow, spleen, and lymph nodes revealed malignant B-cells. Subsequent transplantation of the splenic cells induced identical malignant B-cell lymphomagenesis and immunophenotype in athymic nude mice, further confirming its malignant identity. These results indicate that ZBTB24 is a novel tumor suppressor in B-cell malignancy. Ongoing studies are being conducted to understand the mechanistic basis for ZBTB24 tumor suppressive function that may involve transcriptional regulation of its target gene expression. This project is supported by the NIH R01CA232246, R01CA129536, and the John Colaizzi Endowment Fund.
Citation Format: Rongrong Li, Namratha Sheshadri, Jianliang Shen, Junrong Yan, Jaeyong Jung, Muhammad Usama Tariq, Y Lynn Wang, Ping Xie, Wei-Xing Zong. ZBTB24 is a novel tumor suppressor and cooperates with CDKN2A to suppress B-cell lymphomagenesis [abstract]. In: Proceedings of the Fourth AACR International Meeting on Advances in Malignant Lymphoma: Maximizing the Basic-Translational Interface for Clinical Application; 2024 Jun 19-22; Philadelphia, PA. Philadelphia (PA): AACR; Blood Cancer Discov 2024;5(3_Suppl):Abstract nr PO-020.
Abstract PR07: SETD1B mutations confer apoptosis resistance and BCL2 independence in B-cell lymphoma
Authors: Portelinha Ana , Wang Shenqiu , Parsa Sara , Jiang Man , Mohanty Sagarajit , Sharma Soumya , Arya Neeraj , Tavana Omid , Wen Jiayu , Fitzgibbon Jude , Dogan Ahmet , Younes Ana , Melnick Ari M. , Wendel Hans-Guido 
Published: June 2024

Abstract
The translocation t(14;18) activates BCL2 and is considered the initiating genetic lesion in over ninety percent of follicular lymphomas (FL). Surprisingly, FL patients respond poorly to clinically approved inhibitor, venetoclax. The mechanisms underlying BCL2 independence in FL are poorly understood, and it has been speculated that epigenetic rewiring of cell death programs may play a role. We performed separate genome-wide CRISPR/Cas9 screens to explore the mechanisms of resistance to Venetoclax and an experimental MCL-1 inhibitor (S63845) and unveiled the histone lysine methyltransferase SETD1B (KMT2G) as an unexpected mechanism of resistance to both inhibitors in lymphoma. We show that mutations and deletions affecting SETD1B occur in 7% of FLs and 16% of diffuse large B cell lymphomas (DLBCL). In vivo, SETD1B acts as a tumor suppressor gene and cooperates with the related histone-lysine N-methyltransferase 2D (KMT2D) gene leading to a more aggressive disease presentation. This oncogenic cooperation is reflected in the genomes of human lymphoma, where SETD1B mutations typically co-occur with KMT2D mutations. Mechanistically, SETD1B is required to express pro-apoptotic BCL2 family proteins like BIM and BIK. Inhibitors of the KDM5 histone H3K4 de-methylase restore the expression of BIM and BIK, venetoclax sensitivity and lead to synergistic drug effects in SETD1B deficient lymphoma xenografts. Our results highlight a role for SETD1B in the epigenetic regulation of cell death proteins in B cell lymphomas, connecting the loss of SETD1B to lymphoma development and reduced sensitivity to venetoclax.
Citation Format: Ana Portelinha, Shenqiu Wang, Sara Parsa, Man Jiang, Sagarajit Mohanty, Soumya Sharma, Neeraj Arya, Omid Tavana, Jiayu Wen, Jude Fitzgibbon, Ahmet Dogan, Ana Younes, Ari M. Melnick, Hans-Guido Wendel. SETD1B mutations confer apoptosis resistance and BCL2 independence in B-cell lymphoma [abstract]. In: Proceedings of the Fourth AACR International Meeting on Advances in Malignant Lymphoma: Maximizing the Basic-Translational Interface for Clinical Application; 2024 Jun 19-22; Philadelphia, PA. Philadelphia (PA): AACR; Blood Cancer Discov 2024;5(3_Suppl):Abstract nr PR07.
A survey on UK researchers’ views regarding their experiences with the de-identification, anonymisation, release methods and re-identification risk estimation for clinical trial datasets
Authors: Rodriguez Aryelly , Lewis Steff C , Eldridge Sandra , Jackson Tracy , Weir Christopher J 
Published: June 2024

Background: There are increasing pressures for anonymised datasets from clinical trials to be shared across the scientific community. However, there is no standardised set of recommendations on how to anonymise and prepare clinical trial datasets for sharing, while an ever-increasing number of anonymised datasets are becoming available for secondary research. Our aim was to explore the current views and experiences of researchers in the United Kingdom about de-identification, anonymisation, release methods and re-identification risk estimation for clinical trial datasets. Methods: We used an online exploratory cross-sectional descriptive survey that consisted of both open-ended and closed questions. Results: We had 38 responses to invitation from June 2022 to October 2022. However, 35 participants (92%) used internal documentation and published guidance to de-identify/anonymise clinical trial datasets. De-identification, followed by anonymisation and then fulfilling data holders’ requirements before access was granted (controlled access), was the most common process for releasing the datasets as reported by 18 (47%) participants. However, 11 participants (29%) had previous knowledge of re-identification risk estimation, but they did not use any of the methodologies. Experiences in the process of de-identifying/anonymising the datasets and maintaining such datasets were mostly negative, and the main reported issues were lack of resources, guidance, and training. Conclusion: The majority of responders reported using documented processes for de-identification and anonymisation. However, our survey results clearly indicate that there are still gaps in the areas of guidance, resources and training to fulfil sharing requests of de-identified/anonymised datasets, and that re-identification risk estimation is an underdeveloped area.