bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Gold(I)‐Catalyzed Tandem Oxidative Ring‐Opening/C—C Bond Cleavage Reactions of Vinylidenecyclopropanes with Secondary Amines under an Oxygen Atmosphere.
Authors: Lu Bei‐Li , Shi Min 
Published: December 2011

AbstractThe title reaction offers an alternative approach for the construction of acryl amides, that in the case of fully substituted acrylamides are difficult prepare according to previous methods.
ChemInform Abstract: Suzuki Cross‐Coupling Reactions of Aryl Chlorides Using [Cl2Pd(COD)]/piperazine Derivative under Microwave Conditions.
Authors: Zhou Zhong‐Gao , Shi Ji‐Cheng , Hu Qiao‐Sheng , Xie Yong‐Rong , Du Zi‐Yi , Zhang Shi‐Yong 
Published: December 2011

AbstractAryl halides react with phenylboronic acid affording biphenyl compounds (III) in excellent yields.
ChemInform Abstract: A Class of Benzene Backbone‐Based Olefin—Sulfoxide Ligands for Rh‐Catalyzed Enantioselective Addition of Arylboronic Acids to Enones.
Authors: Xue Feng , Li Xincheng , Wan Boshun 
Published: December 2011

AbstractThe chiral sulfoxide (SSO) efficiently promotes the addition of aryl boronic acids as well as trifluoroborates to cyclic enones and enoates.
ChemInform Abstract: Iodonium Salts Are Key Intermediates in Pd‐Catalyzed Acetoxylation of Pyrroles.
Authors: Lubriks Dmitrijs , Sokolovs Igors , Suna Edgars 
Published: December 2011

AbstractThe reaction of pyrroles and indoles with Ph‐I(O‐Ac)2 proceeds via initial regioselective formation of iodonium acetate intermediates which are converted into acetoxy derivatives.
ChemInform Abstract: Gold‐Catalyzed Transformation of 2‐Alkynyl Arylazides: Efficient Access to the Valuable Pseudoindoxyl and Indolyl Frameworks.
Authors: Wetzel Alexander , Gagosz Fabien 
Published: December 2011

AbstractThe reaction affords 2,2‐disubstituted indolin‐3‐ones or 3‐substituted indoles.
ChemInform Abstract: Novel Approach Towards 2‐Substituted Aminobenzimidazoles on Imidazolium Ion Tag under Focused Microwave Irradiation.
Authors: Chanda Kaushik , Maiti Barnali , Chung Wen‐Sheng , Sun Chung‐Ming 
Published: December 2011

AbstractA general approach towards aminobenzimidazoles (V) is presented, using an ionic liquid support for more operational simplicity.
ChemInform Abstract: Novel Synthetic Methodologies. Part 209. The First Multicomponent Synthesis of Propargyl‐1,2,3‐triazoles.
Authors: Das Biswanath , Bhunia Nisith , Lingaiah Maram , Reddy Parigi Raghavendar 
Published: December 2011

AbstractThe process is successful if aromatic aldehydes are used.
ChemInform Abstract: Efficient Synthesis of (3E)‐3‐[Amino(aryl)methylidene]chromane‐2,4‐diones (= (3E)‐3[Amino(aryl)methylene]‐2H‐1‐benzopyran‐2,4(3H)‐diones) via a Three‐Component Reaction.
Authors: Ghabraie Elmira , Bararjanian Morteza , Balalaie Saeed , Rominger Frank , Bijanzadeh Hamid Reza 
Published: December 2011

AbstractMichael‐type addition of hydroxycoumarins (I) towards β‐nitrostyrenes (II) in the presence of ammonium acetate provides access to title amino(aryl)methylenechromanediones (III) in high yields.
ChemInform Abstract: One‐Pot Synthesis of Benzo[f]quinolin‐3‐ones and Benzo[a]phenanthridein‐5‐ones by the Photoannulation of 6‐Chloropyridin‐2‐ones and 3‐Chloroisoquinolin‐1‐ones to Phenylacetylene.
Authors: Wang Ren , Lu Shen‐Ci , Zhang Yi‐Ming , Shi Zong‐jun , Zhang Wei 
Published: December 2011

AbstractThe overall reaction proceeds actually through two photo reaction steps containing an chlorine atom transfer addition.
ChemInform Abstract: Synthesis of Fused Multicyclic Compounds Containing Macrocycles by Dienyne Ring‐Closing Metathesis and Diels—Alder Reactions.
Authors: Park Hyeon , Choi Tae‐Lim 
Published: December 2011

AbstractRCM and Diels—Alder reactions are combined in an one‐pot approach to give complex heterocyclic compounds, e.g. (XI).
ChemInform Abstract: DDQ‐Promoted Dehydrogenation from Natural Rigid Polycyclic Acids or Flexible Alkyl Acids to Generate Lactones by a Radical Ion Mechanism.
Authors: Ding Ye , Huang Zhangjian , Yin Jian , Lai Yisheng , Zhang Shibo , Zhang Zhiguo , Fang Lei , Peng Sixun , Zhang Yihua 
Published: December 2011

AbstractThe novel and facile presented title reaction proceeds only in the presence of a carbonyl group at C—12 and a H‐atom at C—13, and it needs a free carboxyl group at C—28 in the natural rigid reactant.
ChemInform Abstract: Synthesis of Novel 2‐Cyano‐7‐deaza‐8‐azapurine‐ and 2‐Cyano‐8‐azapurine Derived Nucleosides.
Authors: Wainwright Philip , et al. et al. 
Published: December 2011

AbstractA novel approach to the synthesis of a variety of target compounds involves the reaction of intermediates (I) or (VII) with protected carbohydrates such as (II).
ChemInform Abstract: Hydrogen‐Bonded Oligoamide Duplexes as Programmable Molecular Recognition Units: A Systematic Approach Towards Directed Self‐Assembly and Controlled Non‐Covalent Synthesis
Authors: Yuan Lihua , Zhang Penghui , Feng Wen , Gong Bing 
Published: December 2011

AbstractReview: 131 refs.
Michail Vasil'evič Lomonosov
Authors: Boeck Gisela 
Published: December 2011

AbstractMichail Vasil'evič Lomonosov, der erste russische Wissenschaftler, der international Bedeutung erlangte, war in Moskau, St. Petersburg, Marburg und Freiberg ausgebildet worden. Er wirkte an der Akademie in Petersburg auf chemischem, physikalischem, geologischem, mineralogischem, astronomischem, historischem und philologischem Gebiet. Er war künstlerisch tätig und versuchte sich an einer Glasfabrik. Er war ein humanistischer und volkstümlicher Denker und kannte die Probleme der Volksaufklärung. Am 6. September 1751 hatte Lomonosov in der öffentlichen Akademieversammlung eine Rede über den Nutzen der Chemie gehalten, die sich weniger theoretischen Darlegungen widmet. Lomonosov hatte herausgestellt, dass das Studium der Chemie zwei Ziele verfolge, nämlich die Naturwissenschaften zu vervollkommnen und die Güter des Lebens zu mehren, eine Formulierung, der wir auch heute, im Internationalen Jahr der Chemie, zustimmen können.
Luft‐ und Raumfahrt zum Mitmachen
Authors: Schumacher Elke 
Published: December 2011

AbstractDas Thema Luft‐ und Raumfahrt übt auf Schülerinnen und Schülern eine große Faszination aus. Schade ist nur, dass es als komplex, geheimnisvoll und vor allem unnahbar empfunden wird. Dies zu ändern, hat sich das Deutsche Zentrum für Luft‐ und Raumfahrt (DLR) zum Ziel gesetzt und im Jahr 2000 in Göttingen sein erstes Schülerlabor zum Mitmachen eingerichtet. Die dort gewonnenen überaus positiven Erfahrungen haben dazu geführt, dass inzwischen zehn entsprechende Schülerlabore bundesweit von Hamburg über Berlin und Köln bis Oberpfaffenhofen an den Standorten des DLR oder befreundeter Hochschulen eingerichtet worden sind.
Cobalt + Nickel
Authors: Schwedt Georg 
Published: December 2011

AbstractDas seit fast 200 Jahren bestehende Mineralogische Museum der Universität Bonn, das 1874 eine bedeutende Sammlung vom Gründer des heutigen Rheinischen Mineralien‐Kontors A. Krantz erhielt, zeigt unter anderem systematisch geordnet Minerale zu ausgewählten chemischen Elementen. Sie werden in dieser Serie zum Internationalen Jahr der Chemie 2011 näher vorgestellt.
Variations in SME Characteristics and the Use of Service Intermediaries for R&D
Authors: Castrogiovanni Gary J. , Domenech Josep , Mas‐Verdú Francisco 
Published: December 2011

AbstractLarge companies increasingly look externally for opportunities to enhance innovation, which has resulted in closer study of innovation systems. We examined the role of service intermediaries (universities, technology centers, and consultants) within these systems using a sample of predominately small‐ and medium‐sized enterprises located in Valencia, Spain. As with studies of large companies, absorptive capacity (e.g., research and development expenditures) was positively related to the likelihood that a firm would engage in service collaborations. However, the rate of collaboration was higher relative to studies dominated by larger companies. Also, there were differences in the pattern of firm characteristics associated with the use of specific services. For example, the level of SME export activity related positively to the use of technology centers, but negatively to university collaborations. Copyright © 2011 ASAC. Published by John Wiley & Sons, Ltd.
Fachkommission Bautechnik – ein Gremium der Bauministerkonferenz
Authors: Schmidt‐Staudinger Renate 
Published: December 2011

AbstractSeit 1. Oktober 2011 ist Herr Ministerialrat Dr.‐Ing. Gerhard Scheuermann (Baden‐Württemberg) neuer Vorsitzender der Fachkommission Bautechnik. Er trat die Nachfolge von Herrn Ministerialrat Dr.‐Ing. Wolfgang Schubert (Bayern) an, der sieben Jahre erfolgreich an der Spitze des Gremiums stand und altersbedingt ausgeschieden ist. Aus diesem Anlass soll im Folgenden die Fachkommission Bautechnik kurz vorgestellt und über den jüngsten Wechsel im Vorsitz berichtet werden.
Alkyne Addition to a Metal‐Stabilized Thiyl Radical: Carbon–Sulfur Bond Formation between 1‐Octyne and [Ru(SP)3]+
Authors: Ouch Kagna , Mashuta Mark S. , Grapperhaus Craig A. 
Published: December 2011

AbstractThe metal‐stabilized thiyl radical complex [Ru(SP)3]+, [Ru‐1]+, {SP = 2‐(diphenylphosphanyl)benzenethiolate} adds 1‐octyne across the cis‐sulfur sites to yield the S‐alkylated dithiolene product [Ru‐1·octyne]+. The product complex exists as a pair of inseparable geometric isomers, which were characterized by X‐ray crystallography, 31P NMR spectroscopy, and cyclic voltammetry. By using electrochemical methods, the rate constant for 1‐octyne addition was determined as 8.7 × 103 M–1 s–1.
Short Synthesis of Chiral 4‐Substituted (S)‐Imidazolinium Salts Bearing Sulfonates and Their Use in γ‐Selective Reactions of Allylic Halides with Grignard Reagents
Authors: Latham Christopher M. , Blake Alexander J. , Lewis William , Lawrence Matthew , Woodward Simon 
Published: December 2011

AbstractA one‐pot reaction of Boc‐protected amino alcohols and 2‐sulfobenzoic anhydride followed by the addition of a wide variety of primary amines has allowed rapid access to diverse libraries of amidosulfonates 1,2‐C6H4(SO3–)(COCHR1CH2NH2+R2) (R1 = Bn, iPr, Ph; R2 = aryl, CHMePh, 1‐adamantyl), of which two examples have been characterised by X‐ray crystallography. These reactions proceed by SN2 opening of unisolated oxazoline intermediates. The amidosulfonates have been converted to imidazolinium sulfonate zwitterions (N‐heterocyclic carbene precursors) in a two‐step process, which involved reduction with BH3·SMe2 and cyclisation with HC(OEt)3. Two examples (R1 = Bn, R2 = 2,6‐iPrC6H3 and R1 = iPr, R2 = 3,5‐Me2C6H3) have been crystallographically characterised, the latter as a PF6 salt. The imidazolinium sulfonate zwitterions (1 mol‐%) catalysed additions of RMgBr (R = alkyl) to (E)‐ArC(R)=CHCH2Br (R = H, Me). Additions to cinnamyl bromides showed high γ (SN2′) selectivity (up to 18.4:1) and provided significantly enantiomerically enriched products (up to 82 % ee).
Application of Flow Chemistry to the Selective Reduction of Esters to Aldehydes
Authors: de M. Muñoz Juan , Alcázar Jesús , de la Hoz Antonio , Díaz‐Ortiz Angel 
Published: December 2011

AbstractThe reduction of esters to aldehydes is an important transformation in organic chemistry and several reducing agents have been described. However, the use of this reaction in medicinal and natural product chemistry is limited due to the instability of the intermediates and the high reactivity of the reaction products. In the current article, the general and selective reduction of esters with diisobutyl‐tert‐butoxyaluminum hydride in flow is reported. This reagent allows esters to be reduced in the presence of different functional groups, including those considered to be of similar or higher reactivity.
Connexin 32 is involved in mitosis
Authors: Mones Saleh , Bordignon Benoit , Fontes Michel 
Published: December 2011

AbstractThe X‐linked form of Charcot‐Marie‐Tooth disorder (CMTX) is the second most frequent type (15% of CMT forms). It involves the GJB1 gene coding for connexin 32, a protein involved in gap junction formation and function. There is no curative treatment for CMTX. We present data on transgenic lines that was accomplished by inserting a human BAC carrying the GJB1 gene, in which two different mutations in connexin 32 (Cx32) observed in patients were introduced. Investigation of these models implicated Cx32 in the control of mitotic stability. The model in which Gjb1 has been invalidated had the same phenotype. This new function for Cx32 was recently confirmed by results from the Mitocheck program. Locomotor impediment was seen in the behavior of these animals, the severity of which correlated with transgene copy number and RNA expression. © Wiley Periodicals, Inc.
Localization of pain‐related brain activation: A meta‐analysis of neuroimaging data
Authors: Duerden Emma G. , Albanese Marie‐Claire 
Published: December 2011

AbstractA meta‐analysis of 140 neuroimaging studies was performed using the activation‐likelihood‐estimate (ALE) method to explore the location and extent of activation in the brain in response to noxious stimuli in healthy volunteers. The first analysis involved the creation of a likelihood map illustrating brain activation common across studies using noxious stimuli. The left thalamus, right anterior cingulate cortex (ACC), bilateral anterior insulae, and left dorsal posterior insula had the highest likelihood of being activated. The second analysis contrasted noxious cold with noxious heat stimulation and revealed higher likelihood of activation to noxious cold in the subgenual ACC and the amygdala. The third analysis assessed the implications of using either a warm stimulus or a resting baseline as the control condition to reveal activation attributed to noxious heat. Comparing noxious heat to warm stimulation led to peak ALE values that were restricted to cortical regions with known nociceptive input. The fourth analysis tested for a hemispheric dominance in pain processing and showed the importance of the right hemisphere, with the strongest ALE peaks and clusters found in the right insula and ACC. The fifth analysis compared noxious muscle with cutaneous stimuli and the former type was more likely to evoke activation in the posterior and anterior cingulate cortices, precuneus, dorsolateral prefrontal cortex, and cerebellum. In general, results indicate that some brain regions such as the thalamus, insula and ACC have a significant likelihood of activation regardless of the type of noxious stimuli, while other brain regions show a stimulus‐specific likelihood of being activated. Hum Brain Mapp, 2013. © 2011 Wiley Periodicals, Inc.
Hepatic endoplasmic reticulum stress in obesity: Deeper insights into processes, but are they relevant to nonalcoholic steatohepatitis?
Authors: Leclercq Isabelle A. , Van Rooyen Derrick M. , Farrell Geoffrey C. , Kowdley Kris , McCaughan Geoffrey , Trautwein Christian 
Published: December 2011

Abstract

The endoplasmic reticulum (ER) is the main site of protein and lipid synthesis, membrane biogenesis, xenobiotic detoxification and cellular calcium storage, and perturbation of ER homeostasis leads to stress and the activation of the unfolded protein response. Chronic activation of ER stress has been shown to have an important role in the development of insulin resistance and diabetes in obesity. However, the mechanisms that lead to chronic ER stress in a metabolic context in general, and in obesity in particular, are not understood. Here we comparatively examined the proteomic and lipidomic landscape of hepatic ER purified from lean and obese mice to explore the mechanisms of chronic ER stress in obesity. We found suppression of protein but stimulation of lipid synthesis in the obese ER without significant alterations in chaperone content. Alterations in ER fatty acid and lipid composition result in the inhibition of sarco/endoplasmic reticulum calcium ATPase (SERCA) activity and ER stress. Correcting the obesity-induced alteration of ER phospholipid composition or hepatic

Serca

over-expression

in vivo

both reduced chronic ER stress and improved glucose homeostasis. Hence, we established that abnormal lipid and calcium metabolism are important contributors to hepatic ER stress in obesity. (Hepatology 2011
Phosphatidylcholines as regulators of glucose and lipid homeostasis: Promises and potential risks
Authors: Hohenester Simon , Beuers Ulrich , Kowdley Kris , McCaughan Geoffrey , Trautwein Christian 
Published: December 2011

Abstract

Nuclear hormone receptors regulate diverse metabolic pathways and the orphan nuclear receptor LRH-1 (also known as NR5A2) regulates bile acid biosynthesis. Structural studies have identified phospholipids as potential LRH-1 ligands, but their functional relevance is unclear. Here we show that an unusual phosphatidyl-choline species with two saturated 12 carbon fatty acid acyl side chains (dilauroyl phosphatidylcholine (DLPC)) is an LRH-1 agonist ligand in vitro. DLPC treatment induces bile acid biosynthetic enzymes in mouse liver, increases bile acid levels, and lowers hepatic triglycerides and serum glucose. DLPC treatment also decreases hepatic steatosis and improves glucose homeostasis in two mouse models of insulin resistance. Both the antidiabetic and lipotropic effects are lost in liver-specific Lrh-1 knockouts. These findings identify an LRH-1 dependent phosphatidylcholine signalling pathway that regulates bile acid metabolism and glucose homeostasis.
Treatment for chemotherapy‐induced alopecia in mice using parathyroid hormone agonists and antagonists linked to a collagen binding domain
Authors: Katikaneni Ranjitha , Ponnapakkam Tulasi , Suda Hirofumi , Miyata Shigeru , Sakon Joshua , Matsushita Osamu , Gensure Robert C. 
Published: December 2011

AbstractParathyroid hormone (PTH) agonists and antagonists have been shown to improve hair growth after chemotherapy; however, rapid clearance and systemic side‐effects complicate their usage. To facilitate delivery and retention to skin, we fused PTH agonists and antagonists to the collagen binding domain (CBD) of Clostridium histolyticum collagenase. in‐vitro studies showed that the agonist fusion protein, PTH‐CBD, bound collagen and activated the PTH/parathyroid hormone‐related peptide receptor in SaOS‐2 cells. The antagonist fusion proteins, PTH(7–33)‐CBD and PTH([‐1]‐33)‐CBD, also bound collagen and antagonized PTH(1–34) effect in SaOS‐2 cells; however, PTH(7–33)‐CBD had lower intrinsic activity. Distribution studies confirmed uptake of PTH‐CBD to the skin at 1 and 12 hr after subcutaneous injection. We assessed in vivo efficacy of PTH‐CBD and PTH(7–33)‐CBD in C57BL/6J mice. Animals were depilated to synchronize the hair follicles; treated on Day 7 with agonist, antagonist, or vehicle; treated on Day 9 with cyclophosphamide (150 mg/kg i.p.) or vehicle; and sacrificed on Day 39. Normal mice (no chemo and no treatment) showed rapid regrowth of hair and normal histology. Chemo + Vehicle mice showed reduced hair regrowth and decreased pigmentation; histology revealed reduced number and dystrophic anagen/catagen follicles. Chemo + Antagonist mice were grossly and histologically indistinguishable from Chemo + Vehicle mice. Chemo + Agonist mice showed more rapid regrowth and repigmentation of hair; histologically, there was a normal number of hair follicles, most of which were in the anagen phase. Overall, the agonist PTH‐CBD had prominent effects in reducing chemotherapy‐induced damage of hair follicles and may show promise as a therapy for chemotherapy‐induced alopecia.
Preclinical evaluation of Mab CC188 for ovarian cancer imaging
Authors: Xu M. , Rettig M.P. , Sudlow G. , Wang B. , Akers W.J. , Cao D. , Mutch D.G. , DiPersio J.F. , Achilefu S. 
Published: December 2011

AbstractCancer stem cells (CSCs) have been successfully isolated from solid tumors and are believed to be initiating cells of primary, metastatic and recurrent tumors. Imaging and therapeutic reagents targeted to CSCs have potential to detect subclinical tumors and completely eradicate the disease. Previously, we have demonstrated that Mab CC188 binds to colon cancer CD133‐ and CD133+ (CSCs) cells. In this study, we examined the reactivity of Mab CC188 to ovarian cancer cells including CD133+ cells and primary tumor tissues using immunofluorescence staining methods and tissue microarray technique. We also explored the feasibility of using NIR dye‐labeled Mab CC188 probe to image ovarian tumors in vivo. Mab CC188 stains both CD133‐ and CD133+ cells of ovarian cancer. Tissue microarray analysis reveals that 75% (92/123) of ovarian cancer cases are positively stained with Mab CC188. Weak positive (±), positive (+), strong positive (++) and very strong positive (+++) stains are 14.8, 3.7, 11 and 24.4%, respectively. In contrast, Mab CC188 staining is low in normal cells and tissues. In vivo study show that significant amounts of the probe accumulates in the excretion organs in the early period postinjection. At 24 hr, the imaging probes have largely accumulates in the tumor, while the intensity of the imaging probe decreases in the liver. The tumor uptake was still evident at 120‐hr postinjection. Our work suggests that Mab CC188‐based imaging and therapeutic reagents are capable of detecting early stage ovarian tumors and effectively treating the tumor.
Body mass index change in adulthood and lung and upper aerodigestive tract cancers
Authors: Tarleton Heather P. , Park Sungshim Lani , Zhu Wei‐Ming , Lee Yuan‐Chin Amy , Hashibe Mia , Morgenstern Hal , Tashkin Donald P. , Mao Jenny T. , Cozen Wendy , Mack Thomas M. , Zhang Zuo‐Feng 
Published: December 2011

AbstractBody mass index (BMI) has been inversely associated with lung and upper aerodigestive tract (UADT) cancers. However, only a few studies have assessed BMI change in adulthood in relation to cancer. To understand the relationship between BMI change and these cancers in both men and women, we analyzed data from a population‐based case–control study conducted in Los Angeles County. Adulthood BMI change was measured as the proportional change in BMI between age 21 and 1 year before interview or diagnosis. Five categories of BMI change were included, and individuals with no more than a 5% loss or gain were defined as having a stable BMI (reference group). Adjusted odds ratios (ORs) and their 95% confidence intervals (CIs) were estimated using logistic regression models. Potential confounders included age, gender, ethnicity, education, tobacco smoking and energy intake. For UADT cancers, we also adjusted for alcohol drinking status and frequency. A BMI gain of 25% or higher in adulthood was inversely associated with lung cancer (OR 0.53, 95% CI 0.33–0.84) and UADT cancers (OR 0.44, 95% CI 0.27–0.71). In subgroup analyses, a BMI gain of ≥25% was inversely associated with lung and UADT cancers among current and former smokers, as well as among current and former alcohol drinkers. The inverse association persisted among moderate and heavy smokers (≥20 pack‐years). The observed inverse associations between adulthood BMI gain and lung and UADT cancers indicate a potential role for body weight‐related biological pathways in the development of lung and UADT cancers.