bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of tritiated JNJ‐GluN2B‐5 (3‐[3H] 1‐(azetidin‐1‐yl)‐2‐(6‐(4‐fluoro‐3‐methyl‐phenyl)pyrrolo[3,2‐b]pyridin‐1‐yl)ethanone), a high affinity GluN2B radioligand with selectivity over sigma receptors
Authors: Schoellerman Jeffrey , Lord Brian , Bhattacharya Anindya , Stenne Brice , Wall Jessica L. , Rech Jason , Letavic Michael , Bonaventure Pascal , Balana Bartosz 
Published: May 2024

AbstractHere, we describe the characterization of a radioligand selective for GluN2B‐containing NMDA receptors, 3‐[3H] 1‐(azetidin‐1‐yl)‐2‐(6‐(4‐fluoro‐3‐methyl‐phenyl)pyrrolo[3,2‐b]pyridin‐1‐yl)ethanone ([3H]‐JNJ‐ GluN2B‐5). In rat cortical membranes, the compound bound to a single site, and the following kinetic parameters were measured; association rate constant Kon = 0.0066 ± 0.0006 min−1 nM−1, dissociation rate constant Koff = 0.0210 ± 0.0001 min−1 indicating calculated KD = Koff/Kon = 3.3 ± 0.4 nM, (mean ± SEM, n = 3). The equilibrium dissociation constant determined from saturation binding experiments in rat cortex was KD of 2.6 ± 0.3 nM (mean ± SEM, n = 3). In contrast to the widely used GluN2B radioligand [3H]‐Ro 25‐6981, whose affinity Ki for sigma 1 and sigma 2 receptors are 2 and 189 nM, respectively, [3H]‐JNJ‐GluN2B‐5 exhibits no measurable affinity for sigma 1 and sigma 2 receptors (Ki > 10 μM for both) providing distinct selectivity advantages. Anatomical distribution of [3H]‐JNJ‐GluN2B‐5 binding sites in rat, mouse, dog, monkey, and human brain tissue was studied using in vitro autoradiography, which showed high specific binding in the hippocampus and cortex and negligible binding in the cerebellum. Enhanced selectivity for GluN2B‐containing receptors translated to a good signal‐to‐noise ratio in both in vitro radioligand binding and in vitro autoradiography assays. In conclusion, [3H]‐JNJ‐GluN2B‐5 is a high‐affinity GluN2B radioligand with excellent signal‐to‐noise ratio and unprecedented selectivity.image
Mechanisms of synapse‐to‐nucleus calcium signalling in striatal neurons and impairments in Huntington's disease
Authors: Nassrallah Wissam B. , Cheng Judy , Mackay James P. , Hogg Peter W. , Raymond Lynn A. 
Published: May 2024

AbstractHuntington's disease (HD) is a monogenic disorder with autosomal dominant inheritance. In HD patients, neurons in the striatum and cortex degenerate, leading to motor, psychiatric and cognitive disorders. Dysregulated synaptic function and calcium handling are common in many neurodegenerative diseases, including HD. N‐methyl‐D‐aspartate (NMDA) receptor function is enhanced in HD at extrasynaptic sites, altering the balance of calcium‐dependent neuronal survival versus death signalling pathways. Endoplasmic reticulum (ER) calcium handling is also abnormal in HD. The ER, which is continuous with the nuclear envelope, is purportedly involved in nuclear calcium signalling; based on this, we hypothesised that nuclear calcium signalling is altered in HD. We explored this hypothesis with calcium imaging techniques, including simultaneous epifluorescent imaging of cytosolic and nuclear calcium using jRCaMP1b and GCaMP3 sensors, respectively, in striatal spiny projection neurons in cortical–striatal co‐cultures from the YAC128 mouse model of HD. Our data show contributions from a variety of calcium channels to nuclear calcium signalling. NMDA receptors (NMDARs) play an essential role in initiating action potential‐dependent calcium signalling to the nucleus, and ryanodine receptors (RyR) contribute to both cytosolic and nuclear calcium signals. Unlike previous reports in glutamatergic hippocampal and cortical neurons, we found that in GABAergic striatal neurons, L‐type voltage‐gated calcium channels (CaV) contribute to cytosolic, but not nuclear calcium signalling. Calcium imaging also suggests impairments in nuclear calcium signalling in HD striatal neurons, where spontaneous action potential‐dependent calcium transients in the nucleus were smaller in YAC128 striatal neurons compared to those of wild‐type (WT). Our results elucidate mechanisms involved in action potential‐dependent nuclear calcium signalling in GABAergic striatal neurons, and have revealed a clear deficit in this signalling in HD.image
Simultaneous versus sequential fractional CO2 laser and subcision combination for management of post‐acne atrophic scars: A split‐face comparative study
Authors: Tran Bao Quoc , Tran Tu Nguyen Anh , Doan Em Van Loi , Nguyen Thuy Thi Phan , Nguyen Hao Trong 
Published: May 2024

AbstractBackgroundA combination of fractional CO2 laser and subcision is usually employed for the treatment of post‐acne atrophic scars. However, the efficacy and safety of both simultaneous and sequential combination therapies should be explored.AimsTo compare the efficacy and safety of simultaneous and sequential fractional CO2 laser and subcision combination therapies for post‐acne atrophic scars.Patients and MethodsThis single‐blind, split‐face clinical trial included 34 patients with post‐acne atrophic scars at our institution. Each patient underwent three sessions of subcision combined with fractional CO2 laser, with a 1‐month interval between each session. The left side of the face was treated with simultaneous combination therapy, whereas the right side was treated with sequential combination therapy. Treatment efficacy was assessed at 4, 8, and 12 weeks; and 3 and 6 months after the last session.ResultsSimultaneous and sequential treatments demonstrated comparable efficacy. Regarding the adverse events, the side of the face undergoing simultaneous treatment experienced longer swelling duration, higher pain levels during laser treatment, and shorter downtime.ConclusionsDespite the longer swelling time and higher pain levels during laser treatment in the simultaneous treatment side, the effectiveness and satisfaction level of the CO2 fractional laser and subcision for treatment of the acne scars were comparable between the two combinations, with a shorter downtime for the simultaneous than for the sequential combination therapy.
Nurses' intention and attitude to participate in advance care planning: An extended theory of planned behaviour using structural equation modelling–A cross‐sectional study
Authors:   Apiradee , Lin Chung‐Yin , Wirojratana Virapun , Lin Peng‐Chan , Shu Bih‐Ching 
Published: May 2024

AbstractAimsThis study aimed to investigate the factors influencing nurses' intentions to participate in advance care planning (ACP) by examining the mediating roles of attitude, subjective norm, and perceived behavioural control in the relationship between knowledge and intention, using an extended theory of planned behaviour and structural equation modelling.MethodsA descriptive cross‐sectional survey was conducted between January and April 2023, involving 515 registered nurses, selected through two‐stage sampling. Data were collected using a self‐administered online survey distributed via the internal communication system of hospital. Structural equation Modelling was employed to analyse the relationships among knowledge, attitude, subjective norm, perceived behavioural control and intention to participate in ACP.ResultsThe results supported two hypotheses regarding the relationships between knowledge, attitude, subjective norm, perceived behavioural control, and intention (p < 0.05). While the direct effect of knowledge on intention was not significant (β = 0.087, p = 0.292), the total indirect effect through attitude, subjective norm and perceived behavioural control was significant (β = 0.449, p < 0.001), accounting for approximately 83.77% of the total effect on intention. This underscores the critical role of these mediators in influencing nurses' intention to participate in ACP.ConclusionsThis study highlights the significant indirect influence of knowledge on nurses' intentions to participate in ACP through attitude, subjective norms and perceived behavioural control. These findings suggest that targeted educational is needed to enhance ACP participation among nurses.Implications for the Profession and/or Patient CareUnderstanding the role of attitude, subjective norm and perceived behavioural control can enhance nursing practice. Creating supportive environments and promoting interdisciplinary collaboration are crucial. Professional development through training, mentorship and role modelling can empower nurses in ACP. Comprehensive programs that increase knowledge and foster positive attitudes are essential for advancing ACP practice among nurses.ImpactEducational programs aimed at nurses should include components designed to strengthen knowledge and the identified mediators, equipping nurses with the necessary ACP skills. Organizational support through appropriate policy frameworks can facilitate these educational endeavours and ensure a sustainable impact on practice.Reporting MethodThe Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist for cross‐sectional studies.
Mind the gap in kidney care: Translating what we know into what we do
Authors: Luyckx Valerie A. , Tuttle Katherine R. , Abdellatif Dina , Correa‐Rotter Ricardo , Fung Winston W. S. , Haris Agnès , Hsiao Li‐Li , Khalife Makram , Kumaraswami Latha A. , Loud Fiona , Raghavan Vasundhara , Roumeliotis Stefanos , Sierra Marianella , Ulasi Ifeoma , Wang Bill , Lui Siu‐Fai , Liakopoulos Vassilios , Balducci Alessandro ,   for the World Kidney Day Joint Steering Committee
Published: May 2024

AbstractHistorically, it takes an average of 17 years to move new treatments from clinical evidence to daily practice. Given the highly effective treatments now available to prevent or delay kidney disease onset and progression, this is far too long. The time is now to narrow the gap between what we know and what we do. Clear guidelines exist for the prevention and management of common risk factors for kidney disease, such as hypertension and diabetes, but only a fraction of people with these conditions worldwide are diagnosed, and even fewer are treated to target. Similarly, the vast majority of people living with kidney disease are unaware of their condition, because in the early stages it is often silent. Even among patients who have been diagnosed, many do not receive appropriate treatment for kidney disease. Considering the serious consequences of kidney disease progression, kidney failure, or death, it is imperative that treatments are initiated early and appropriately. Opportunities to diagnose and treat kidney disease early must be maximized beginning at the primary care level. Many systematic barriers exist, ranging from patient to clinician to health systems to societal factors. To preserve and improve kidney health for everyone everywhere, each of these barriers must be acknowledged so that sustainable solutions are developed and implemented without further delay.
Sleep quality during pregnancy and fetal growth: A prospective cohort study
Authors: Wu Fan , Sun Li , Chen Jinhuang , Du Yijuan , Fan Zhanhong , Cao Zhiqiu , Liu Huahua , Lei Xiaoling , Zhang Feng 
Published: May 2024

SummaryThe aim of this study is to investigate the association between sleep quality during pregnancy and fetal growth. Pregnant women and their fetuses at 16–20 gestational weeks in Nantong Maternal and Child Health Hospital were recruited. Women were classified as having “good sleep quality” (Pittsburgh Sleep Quality Index score ≤ 5) and “poor sleep quality” (Pittsburgh Sleep Quality Index score > 5) according to the Pittsburgh Sleep Quality Index scores. The fetal growth was evaluated by three ultrasonographic examinations, birth weight and birth length. We used general linear model and multiple linear regression models to estimate the associations. A total of 386 pairs of mother and infant were included in the data analysis. After adjusting for gestational weight gain, anxiety and depression, fetuses in the good sleep quality group had greater abdominal circumference (p = 0.039 for 28–31+6 weeks gestation, p = 0.012 for 37–40+6 weeks gestation) and femur length (p = 0.014 for 28–31+6 weeks gestation, p = 0.041for 37–40+6 weeks gestation) at 28–31+6 weeks gestation and 37–40+6 weeks gestation, and increased femur length (p = 0.007) at 28–31+6 weeks gestation. Birth weights (p = 0.018) were positively associated with sleep quality. Poor sleep quality was associated with poor intrauterine physical development, decreased abdominal circumference and femur length, and lower birth weight after adjusting for confounding factors. Attention to the fetal growth of pregnant women with poor sleep quality has the potential to decrease the risk of adverse fetal outcomes.
Reaching out beyond the national border? How far‐right actors in Germany and Norway evaluate transnationalism
Authors: Fangen Katrine , Weisskircher Manès 
Published: May 2024

AbstractResearch has emphasised the importance of far‐right transnationalism, in terms of both ideology and practice. Yet, the literature lacks a comprehensive analysis of how far‐right actors themselves reflect their transnational practices (or lack thereof), such as party‐level exchange, joint protest events, or online communication. Drawing on original interview data from Germany and Norway, our research unveils that while far‐right ‘nationalists’ generally endorse transnational activities, only a minority actively participates. The interviewees perceive transnational practices as opportunities for strategic learning, showcasing of collective strength, and networking. Simultaneously, they express concerns about being associated with extremists and getting entangled in conflict‐ridden areas. Theoretically, we discuss the role of ideology and everyday life as well as the importance of only limited strategic incentives for understanding far‐right transnationalism. In doing so, we draw parallels to experiences made by left‐wing actors. Moreover, we underline the potential of Granovetter's ‘strength of weak ties’ for far‐right diffusion.
Determining adaptability of farmer bred spring wheat (Triticum aestivum L.) genotypes to Canadian organic production using stability analysis
Authors: Carkner M. K. , Entz M. H. 
Published: May 2024

AbstractParticipatory plant breeding (PPB) is a collaborative process between farmers, plant breeders and researchers to create germplasm specifically bred for target environments. We sought to examine the yield performance and adaptability of genotypes from an organic PPB wheat programme under organic management across the Canadian prairies. We evaluated 25 farmer genotypes and 6 commercial cultivars in locations in Alberta, Saskatchewan and Manitoba, totalling 12 organic environments. The top performers most responsive to higher yield environments were three farmer genotypes (BL34‐SW, BL43C‐TM and BJ13‐GW) and one check cultivar (Vesper). Genotype plus genotype by environment (GGE) biplot analysis indicated that one farmer genotype (BL23‐AS) and one check cultivar (Vesper) demonstrated high yield and greater organic adaptation than other genotypes tested. Two registered cultivars (AAC Brandon and Jake) had low yield and poor adaptation, as did one farmer genotype (PWA10B‐LD). Yield was positively and strongly correlated with height, anthesis and mature biomass and kernel number per unit area. The results provide evidence that early generation farmer selection is an effective breeding strategy for discovering wheat genotypes with high yield and excellent adaptability to organic production systems in Canada.
The identity of what? Pluralism, practical interests, and individuation
Authors: Dranseika Vilius , Nichols Shaun , Shoemaker David 
Published: May 2024

AbstractIn this paper, we present a set of preregistered studies inspired by both Lockean pluralism about individuation and discussions of conjoined twinning in the contemporary personal identity debate. In combination, these studies provide evidence of folk pluralism about individuation of “individuals like us” and also ways in which individuation judgments are integral to practical interests. First, our studies show that individuation judgments depend on a sortal supplied. Study participants tend to see two people or persons but only one organism in case of dicephalic twins, and they do not find these two verdicts inconsistent. Second, study participants tend to be pluralist in a sense that they find it acceptable to consider dicephalic twins to be—at the same time—two persons sharing one body and one two‐headed person. Third, while both perspectives are available, when reasons for counting are made salient, study participants tend to resolve pluralism in line with practical interests relevant in the context.
Relationship between nutrition indicators and pneumonia risk among stable schizophrenia patients: a retrospective study
Authors: Cai Duanfang , Wang Yilin , Chen Xiaoyan 
Published: May 2024

AbstractBackgroundIt is reported that reduced physical activity and malnutrition may trigger pneumonia, and the utilisation of the geriatric nutritional risk index (GNRI) upon admission to long‐term nursing care can enable the implementation of accurate and timely rehabilitation and nutritional support, which may, in turn, minimise pneumonia incidence. However, to date, there is no reported association between GNRI and pneumonia among stable schizophrenic patients.MethodsThis is a retrospective investigation. We enrolled 434 hospitalised subjects aged ≥50 years, who were diagnosed with stable schizophrenia between January 2017 and June 2022. Baseline nutritional status information during the stable stage of schizophrenia was evaluated using body mass index, serum albumin, and GNRI. In addition, pneumonia‐based information, including diagnosis and treatment, was retrospectively obtained within 1 year. To examine the potential association between nutrition indicators and pneumonia risk among stable schizophrenia patients, we employed a logistic regression analysis.ResultsThe pneumonia incidence among all stable schizophrenia patients was 10.14%, and there were no statistically significant difference between sexes (male vs. female, 10.63% vs. 9.44%, P = 0.687). Based on the univariate analysis of nutrition indicators and pneumonia, female patients exhibited a strong correlation between serum albumin and pneumonia (P = 0.022). Furthermore, we adjusted for potential influencing factors of pneumonia infection, and confirmed that only serum albumin was linked to pneumonia risk in female stable schizophrenia patients (odds ratio = 0.854, 95% CI: 0.749–0.975, P = 0.02).ConclusionsBased on our analysis, serum albumin was strongly correlated with pneumonia risk in female stable schizophrenia patients.
Interactions between fractional solitons in bimodal fiber cavities
Authors: Zangmo Tandin , Mayteevarunyoo Thawatchai , Malomed Boris A. 
Published: May 2024

AbstractWe introduce a system of fractional nonlinear Schrödinger equations (FNLSEs) which model the copropagation of optical waves carried by different wavelengths or mutually orthogonal circular polarizations in fiber‐laser cavities with the effective fractional group‐velocity dispersion (FGVD), which were recently made available to the experiment. In the FNLSE system, the FGVD terms are represented by the Riesz derivative, with the respective Lévy index (LI). The FNLSEs, which include the self‐phase‐modulation (SPM) nonlinearity, are coupled by the cross‐phase‐modulation (XPM) terms, and separated by a group‐velocity (GV) mismatch (rapidity). By means of systematic simulations, we analyze collisions and bound states of solitons in the XPM‐coupled system, varying the LI and GV mismatch. Outcomes of collisions between the solitons include rebound, conversion of the colliding single‐component solitons into a pair of two‐component ones, merger of the solitons into a breather, their mutual passage leading to excitation of intrinsic vibrations, and the elastic interaction. Families of stable two‐component soliton bound states are constructed too, featuring a rapidity which is intermediate between those of the two components.
Accurate calculation method of terrain viewshed for wireless signal as line of sight
Authors: Wang Yiwen , Dou Wanfeng 
Published: May 2024

AbstractViewshed analysis is an important research content of digital terrain analysis. The terrain viewshed refers to the range that can be seen at the current position, which varies with the nature of the observer. When the observer is a wireless signal tower, it is the communication viewshed, which refers to the area consisted of grid cells where the receiving antennas can receive the signals from a transmitting antenna set up on a grid cell of terrain. The core of base station location problem includes two aspects: combinatorial optimization and the calculation of the coverage rate of signal. The calculation of communication viewshed is an important research content for determining signal coverage range. In this article, we propose an accurate communication viewshed computation algorithm for wireless signal (CVCWS) using the projection curve of 3D Fresnel zone analysis based on DEM. The CVCWS method can calculate the signal reception quality at different locations more precisely. Besides, a signal attenuation model is proposed to compute the theoretical attenuation value according to the signal receiving quality index. The proposed algorithm is compared with the existing DEM‐based communication viewshed algorithms, and the theoretical attenuation values are compared with the measured values. The experimental results show that the theoretical values gained by the CVCWS algorithm are close to the measured values, indicating high accuracy of the CVCWS algorithm. The proposed method can provide theoretical support for communication tower location planning and other related applications.
Toward Controllable Generative Design: A Conceptual Design Generation Approach Leveraging the Function–Behavior–Structure Ontology and Large Language Models
Authors: Chen Liuqing , Zuo Haoyu , Cai Zebin , Yin Yuan , Zhang Yuan , Sun Lingyun , Childs Peter , Wang Boheng 
Published: May 2024

Abstract
Recent research in the field of design engineering is primarily focusing on using AI technologies such as Large Language Models (LLMs) to assist early-stage design. The engineer or designer can use LLMs to explore, validate, and compare thousands of generated conceptual stimuli and make final choices. This was seen as a significant stride in advancing the status of the generative approach in computer-aided design. However, it is often difficult to instruct LLMs to obtain novel conceptual solutions and requirement-compliant in real design tasks, due to the lack of transparency and insufficient controllability of LLMs. This study presents an approach to leverage LLMs to infer Function–Behavior–Structure (FBS) ontology for high-quality design concepts. Prompting design based on the FBS model decomposes the design task into three sub-tasks including functional, behavioral, and structural reasoning. In each sub-task, prompting templates and specification signifiers are specified to guide the LLMs to generate concepts. User can determine the selected concepts by judging and evaluating the generated function–structure pairs. A comparative experiment has been conducted to evaluate the concept generation approach. According to the concept evaluation results, our approach achieves the highest scores in concept evaluation, and the generated concepts are more novel, useful, functional, and low cost compared to the baseline.