bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors affecting 12-month unplanned readmissions for chronic obstructive pulmonary disease patients: the effect of mental disorders in an Australian cohort
Authors: Wijekulasuriya Shalini , Sa Zhisheng , Badgery-Parker Tim , Long Janet C , Braithwaite Jeffrey , Chapman David G , Levesque Jean-Frédéric , Watson Diane E , Westbrook Johanna I , Mitchell Rebecca 
Published: June 2024

Abstract

Background
Many individuals with chronic obstructive pulmonary disease (COPD) experience frequent hospitalization and readmissions, which is burdensome on the health system. This study aims to investigate factors associated with unplanned readmissions and mortality following a COPD-related hospitalization over a 12-month period in Australia, focusing on mental disorders and accounting for the acute phase of the COVID-19 pandemic.

Methods
A retrospective cohort study using linked hospitalization and mortality records identified individuals aged ≥40 years who had at least one hospital admission with a principal diagnosis of COPD between 2014 and 2020 in New South Wales, Australia. A semi-competing risk analysis was conducted to examine factors associated with unplanned readmission and mortality.

Results
Adults with a mental disorder diagnosis, specifically anxiety, had a higher risk of 12-month unplanned readmission. Individuals with anxiety and dementia also had a higher risk of mortality pre- and post-unplanned readmission. Individuals who were admitted during the acute phase of the COVID-19 pandemic period had lower risk of unplanned readmission, but higher risk of mortality without unplanned readmission.

Conclusion
Interventions aimed at reducing admissions should consider adults living with mental disorders such as anxiety or dementia to improve healthcare delivery and health outcomes for individuals living with COPD.
Ovomemolins: Egg‐derived peptides that improved cognitive decline after oral administration in mice
Authors: Nakajima Takanobu , Shobako Maiko , Kaneko Kentaro , Kurabayashi Atsushi , Sato Masaru , Ohinata Kousaku 
Published: June 2024

AbstractEggs not only contain all the molecules necessary to nurture new life but are also rich in nutrients such as high‐quality protein. For example, epidemiologic studies have shown that egg intake is positively correlated with cognitive function. Thus, we specifically examined the effect of ovalbumin, a major protein present in egg whites, on cognitive function. First, we found that an orally administered enzymatic digest of ovalbumin improves cognitive function in mice fed a high‐fat diet. Then, we narrowed down candidate peptides based on the prediction of peptide production according to enzyme‐substrate specificity and comprehensive peptide analysis of the digest. We found that three peptides, namely ILPEY, LYRGGLEP, and ILELP, improve cognitive function after oral administration. We also showed that ILPEY, LYRGGLEP, and ILELP were present in the digest and named them ovomemolins A (OMA), B, and C, respectively. Notably, ovomemolins are the first peptides derived from egg whites that have been shown to improve cognitive function. The cognitive improvement induced by OMA, the most abundant of the peptides in the digest, was inhibited by methyllycaconitine, an antagonist of α7nAChR, which is known to be related to memory. These results suggest that OMA improves cognitive function through the acetylcholine system. After OMA administration, brain‐derived neurotrophic factor (BDNF) mRNA expression and the number of 5‐bromo‐2′‐deoxyuridine‐positive cells suggested that OMA increases hippocampal BDNF expression and neurogenesis.
Dynamic Magnetic Resonance Imaging Protocol: An Effective and Useful Tool to Assess Discoid Lateral Meniscus Instability in Children
Authors: Cance Nicolas , Rouchaud Aymeric , Chousta Aygulph , Josse Antoine , James Dan Michael , Chotel Franck 
Published: June 2024

Objectives:
One of the most common symptoms in cases of discoid lateral meniscus (DLM) in children is a “snapping” knee. The clock in extension, followed by a pop in flexion, perceived by the clinician, reflects the meniscal displacement caused by the peripheral meniscocapsular detachment. Standard magnetic resonance imaging (MRI) results in a 40% false-negative rate for detecting this instability. The hypothesis was that a dynamic MRI protocol could reduce the false negative rate and improve the efficiency of the MRI in detecting the direction of instability.

Methods:
Eight DLM knees (8 patients) with snapping knees (grade 2 of Lyon’s classification) were included in this monocentric prospective preliminary study in a referral center of pediatric orthopaedic surgery. Every patient underwent a dynamic MRI protocol with both T2-Fat-Sat sagittal and coronal slices, performed “after the clock” and again “after the pop” in a knee with standard 20 degrees of flexion during acquisition. All the MRI data were correlated with an arthroscopic description of the peripheral tear of the DLM according to Ahn’s classification to assess for diagnostic accuracy.

Results:
The standard MRI protocol resulted in a false-negative rate of 50% for detecting the direction of instability. The dynamic MRI protocol allowed the identification of, and classification of the meniscal instability, meniscal shift, and meniscocapsular tear in 8 of 8 patients (0% false-negative rate), perfectly correlated with arthroscopic findings.

Conclusion:
This preliminary series, although short, allowed us to understand all the types of movements and lesions associated with the child’s discoid meniscus. The detailed case analysis showed a strong benefit of such a protocol for planning the surgical suture procedure. The functionality and reliability of the dynamic MRI protocol is a good and method relatively simple method which does not require specific equipment, minimizing any additional cost compared with standard MRI.

Level of Evidence:
Level IV.
Development and Validation of Eyes Care Bundle for Mechanically Ventilated Patients
Authors: Ali Sahar Ahmed , Mohammed Tark Ahmed , Mohammed Mona Aly , Mahgoub Asmaa Aly 
Published: June 2024

Lack of proper eye care (EC) for mechanically ventilated patients can lead to serious ocular complications. Objective of this study is to develop and validate eyes care bundle for mechanically ventilated patients. A Delphi design study was conducted between March and May 2021. The Content Validity Index (CVI) was used to calculate the degree of agreement among the experts to analyze the bundle. Content validity was determined by 5 experts using a 4-point Likert scale. They evaluated the items in terms of the following: 1 = “irrelevant,” 2 = “somewhat relevant if the phrasing is profoundly adjusted,” 3 = “relevant with some adjustment,” and 4 = “very relevant.” The CVI was applied, and the accepted value was ≥0.50. The validation of EC bundle was conducted through 3 rounds after developed it based on the evaluated research evidence. The items were reviewed for content and face validity. The bundle was validated with 5 items with a total CVI of 0.96, a face validity of 1, and a Scale-Level Content Validity Index/Universal Agreement calculation method value of 0.8. This bundle can help critical care nurses, doctors, academics, and students assess and provide standard EC for mechanically ventilated patients.
Individual and additive-effect relationships of menopausal symptoms and subjective cognitive decline among nurses during menopausal transition: a cross-sectional study
Authors: He Xudong , Hou Fangyan , Shen Xiaona , Zhao Di , Zhao Xiangyu , Qi Meiling , Li Ping 
Published: June 2024

Abstract

Objective
This study aimed to examine the individual and additive-effect relationships between menopausal symptoms and subjective cognitive decline among nurses during menopausal transition.

Methods
Between February and September 2019, a convenience sampling strategy was used, involving 1,335 Chinese nurses undergoing menopausal transition. A general information survey that included the Subjective Cognitive Decline Scale and the Menopause Rating Scale was completed. Based on a cut-off point of the subjective cognitive decline score of 7.5, the overall sample was divided into mild and severe groups. Propensity score matching was performed to balance covariates of mild and severe subjective cognitive decline. The individual and cumulative effects of menopausal symptoms and subjective cognitive decline were analyzed using binary logistic regression and the Cochran-Armitage trend test, respectively.

Results
After propensity score matching, none of the parameters showed significant differences between the groups. Logistic regression analysis revealed that four menopausal symptoms were closely associated with severe subjective cognitive decline. The Cochran-Armitage trend test indicated odds ratios linking the presence of these symptoms with increased severe subjective cognitive impairment. In addition, nurses simultaneously experiencing two or more core menopausal symptoms were over six times more likely to have severe subjective cognitive decline than nurses experiencing none or one core menopausal symptom during menopausal transition.

Conclusions
Individual and additive numbers of menopausal symptoms significantly influenced subjective cognitive decline in nurses during their menopausal transition. These findings suggest that interventions aimed at enhancing the cognitive performance of nurses experiencing menopause should consider menopausal symptoms.
The Dual-plane Technique for Correcting Sunken Upper Eyelid Deformity with Hyaluronic Acid Filler Injections
Authors: Bagci Bulent 
Published: June 2024

Summary:The dual-plane technique is an effective and safe method that aims to correct sunken upper eyelid deformity by increasing the volume of retro-orbicularis oculi fat, and especially supraorbital fat, through hyaluronic acid filler injection. Filling in the superficial plane allows for a more precise correction of sunken upper eyelid deformity with a smaller amount of filler. Contrary to common knowledge in the literature, this technique—filling the superficial plane with a filler, such as subcutaneous fat—does not lead to irregular filler accumulation and surface irregularity on the skin. Additionally, the risk of complications is much lower compared with techniques that recommend filling the deep plane using a sharp needle.
Mixed Reality in the Operating Room: An Initial Use in Frontal Sinus Setback in Gender-affirming Facial Surgery
Authors: Kass Nicolás M. , Cheng Lucille G. , Irgebay Zhazira , Moroni Elizabeth , Dvoracek Lucas , Canton Stephen P. , Sharma Nikhil , Steuer Fritz , Andrews Edward G. , Goldstein Jesse A. 
Published: June 2024

Summary:
Demand for gender-affirming facial surgery is growing rapidly. Frontal sinus setback, one of the key procedures used in gender-affirming facial surgery, has a particularly high impact on gender perception. Mixed reality (MR) allows a user to view and virtually overlay three-dimensional imaging on the patient and interact with it in real time. We used the Medivis’s SurgicalAR system in conjunction with the Microsoft HoloLens Lucille2 (Microsoft). Computed tomography imaging was uploaded to SurgicalAR, and a three-dimensional (3D) hologram was projected onto the display of the HoloLens. The hologram was registered and matched to the patient, allowing the surgeon to view bony anatomy and underlying structures in real time on the patient. The surgeon was able to outline the patient’s frontal sinuses using the hologram as guidance. A 3D printed cutting guide was used for comparison. Negligible difference between the mixed reality-based outline and 3D-printed outline was seen. The process of loading the hologram and marking the frontal sinus outline lasted less than 10 minutes. The workflow and usage described here demonstrate significant promise for the use of mixed reality as imaging and surgical guidance technology in gender-affirming facial surgery.
Isolated Medial Platysmaplasty and Harmonization of the Lower Third of Face with Local Fat Autograft: A Case Report
Authors: Borisenko Anastasiya S. , Sharobaro Valentin I. , Burkhonova Nigora S. , Avdeev Alexey E. , Ermolaev Alexander A. , Ahmed Alsheikh Yousif M. 
Published: June 2024

Summary:
One of the most common complaints of patients seeking plastic surgery is the presence of age-related changes in the lower third of the face. These often include vertical platysmal bands, a double chin, Venus rings, the absence of the cervico-mental angle, hypertonicity of the muscles in the mental area, and insufficient projection of the chin. The development and implementation of less-traumatic methods of correction of the lower third of the face and harmonization of the projection of the cervico-mental region remain relevant. This article discusses a comprehensive and individualized approach with minimally invasive techniques for correcting age-related changes in the lower third of the face and harmonizing the definition of the jawline. Isolated platysmaplasty with autologous local fat grafting to the chin is effective, safe, minimally invasive, and has a short rehabilitation period, with stable long-term aesthetic outcomes.
Prediction of footplate position after implantable collamer lens implantation based on iris and ciliary body morphologies
Authors: Wu Hao , Wang Yi-ou , Chen Jiong-pu , Luo Dong-qiang , Chen Jiao , Zhong Ding-juan , Wang Hua 
Published: June 2024

Purpose:
To investigate the factors affecting footplate position and its influence on vault characteristics after implantable collamer lens (ICL) implantation.

Setting:
Hunan Provincial People's Hospital, Changsha, China.

Design:
Retrospective case series.

Methods:
This study included 124 patients (124 eyes). Ultrasound biomicroscopy (UBM) was performed to assess the iris and ciliary body morphologies and observe the footplate position. Using multiple linear regression, the relationship between various ocular and ICL parameters and the vault as well as the factors affecting the footplate distance (FD) were analyzed. Based on the FD, 3 groups were formed: group 1 (<500 μm), group 2 (500 to 1000 μm), and group 3 (>1000 μm). The distribution of the vault range postoperatively was observed for the 3 groups.

Results:
Ciliary sulcus angle and FD significantly affected the vault (adjusted R
2 = 0.190, F = 6.763, P < .001), with FD being the most important factor influencing the vault (β = −0.383, P < .001). Postoperative UBM revealed that the footplate was located at different positions in the posterior chamber, with the majority (52%) being located on the ciliary body. The mean size of the 4 footplate orientations was 0.88 ± 0.24 mm. Multiple linear regression analysis revealed that ciliary body thickness (CBT), iris curvature (IC), and ICL iris contact length (IRCL) significantly influenced the FD (adjusted R
2 = 0.373, F = 11.432, P < .001). The vault range differed significantly among the 3 groups (X2 = 32.33, P < .001).

Conclusions:
Different postoperative ICL footplate positions significantly affect the vault. CBT, IC, and IRCL can alter the position of the footplate from the expected position. This study provides reference for ICL size selection and vault prediction.
Trends in Sexually Transmitted Infections Associated With the Doxycycline Postexposure Prophylaxis Guidelines in San Francisco
Authors: Liu Andy , Hao Jiayuan , Pickering Trevor A. , Klausner Jeffrey D. 
Published: June 2024

Abstract
The San Francisco Department of Public Health was the first to issue guidance on the use of doxycycline for postexposure prophylaxis against sexually transmitted infections in at-risk populations. We investigated the association between the issuance of these guidelines and rates of male rectal chlamydia, male rectal gonorrhea, and adult male syphilis.
Efficacy of Empirical 131I Radioiodine Therapy in Well-Differentiated Thyroid Carcinoma Patients With Thyroglobulin-Elevated Negative Iodine Scintigraphy Syndrome
Authors: Kim Keunyoung , Hong Chae Moon , Ha Mihyang , Choi Miyoung , Bang Ji-In , Park Sohyun , Seo Youngduk , Chong Ari , Oh So Won , Lee Sang-Woo 
Published: June 2024

Objectives
This study aimed to perform a systematic review and meta-analysis on the efficacy of empirical high-dose radioiodine therapy in treating differentiated thyroid cancer patients with thyroglobulin (Tg)-elevated negative iodine scintigraphy (TENIS) syndrome.

Methods
We searched PubMed, EMBASE, and the Cochrane Library to identify relevant studies published until April 2022. This systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist and registered in an international prospective register of systematic reviews (PROSPERO). Meta-analyses of proportions and odds ratios were performed to assess the beneficial effect of empirical high-dose radioiodine therapy in patients with TENIS syndrome. Subgroup analysis was also performed according to the presence of micrometastasis or macrometastasis.

Results
We identified 14 studies including 690 patients who received empirical high-dose radioiodine therapy for TENIS syndrome. Those who had micrometastasis exhibited additional lesions not previously observed on diagnostic whole-body scan (prop = 0.64, 95% confidence interval [CI], 0.51–0.77) and had reduced serum Tg levels (prop = 0.69; 95% CI, 0.52–0.84) after empirical radioiodine treatment. No such findings were observed among patients with macrometastasis. Moreover, we found that the empirical radioiodine treatment group had lower serum Tg levels than did controls (odds ratio = 0.27; 95% CI, 0.09–0.87), which suggests a lower risk of disease progression.

Conclusions
Our findings indicate that empirical high-dose radioiodine therapy promoted beneficial effects and could be recommended for patients with TENIS syndrome, especially those with micrometastasis.
Post-RFA Pulmonary Vein Stenosis Mimicking Lymphangitic Carcinomatosis in a Patient With History of Liposarcoma
Authors: Kwon Soo Jin , Yoo Ie Ryung , Jung Jung Im 
Published: June 2024

Abstract
A 58-year-old man with resected liposarcoma exhibited persistent irregular interlobular septal thickening of lung on CT concerning lymphangitic metastasis. FDG PET/CT was positive in these foci. There was a narrowing of the pulmonary veins, which had not been seen on the imaging conducted prior to radiofrequency ablation therapy for atrial fibrillation. Lung perfusion scanning demonstrated more extensive hypoperfusion. This case highlights the diagnostic pitfalls of interstitial thickening of the lung in cancer patients. Meticulous history review and nuclear imaging helped distinguish the postablation pulmonary venous stenosis from metastatic spread to the lung interstitium.
18F-FDG Uptake in Pancreatic AL Amyloidosis Associated With Multiple Myeloma
Authors: Kaida Hayato , Chikugo Takaaki , Tanaka Hirokazu , Ishii Kazunari 
Published: June 2024

Abstract
A 60-year-old woman underwent whole-body contrast-enhanced CT because multiple myeloma was suspected. The contrast-enhanced CT showed pancreatic enlargement without main pancreatic duct dilatation and increased peripancreatic fat tissue. 18F-FDG PET/CT demonstrated diffuse uptake in the enlargement of the pancreas, left and right ventricles, and vertebral column. Biopsy and bone marrow aspiration cytology revealed amyloid light-chain amyloidosis associated with multiple myeloma. Chemotherapy was performed; 18F-FDG uptake in the pancreas then disappeared, and the pancreatic enlargement decreased. When diffuse 18F-FDG uptake in pancreatic enlargement is observed in multiple myeloma patients, amyloid light-chain amyloidosis should be considered.
False-Positive Bone Pitfall Lesion and Collateral Circulation
Authors: Moreau Aurélie , Pretet Valentin , Kryza David 
Published: June 2024

Abstract
We report the case of a patient followed up for squamous cell carcinoma of the buccal floor with lymph node involvement. The initial staging PET/CT revealed bone foci that were not definitively pathological in the context of a regional collateral circulation secondary to a defibrillator. A new monitoring examination, conducted due to the rapid local progression, revealed a dissociated evolution of the bone uptake adjacent to the collateral circulation, some confirming false-positives, but one indicating a real metastasis. This case illustrates that bone uptakes without morphological lesions adjacent to a collateral circulation are not easily interpretable.
A Rare Case of Renal Malakoplakia Incidentally Detected on 18F-FDG PET/CT in a Patient With Concomitant Breast Cancer and Lymphoma
Authors: Wakankar Ritwik , Bal Jaspriya , Sharma Kanchan , Dougall Pankaj 
Published: June 2024

Abstract
Malakoplakia is a rare inflammatory disease that most frequently affects the urinary tract. We present the case of a patient who had been receiving treatment for breast cancer, who later on went on to develop diffuse large B-cell lymphoma for which she was started on RCHOP therapy. It was during her treatment that she underwent a whole-body 18F-FDG PET/CT for response evaluation and was incidentally diagnosed to have bilateral renal malakoplakia, which resolved after a prolonged course of antibiotic therapy.
Early nimodipine treatment in reversible cerebral vasoconstriction syndrome: a serial transcranial Doppler study
Authors: Cho Soohyun , Lee Mi Ji 
Published: June 2024

AbstractBackgroundAlthough nimodipine is commonly used to treat reversible cerebral vasoconstriction syndrome (RCVS), its disease-modifying effects are not yet understood. We aimed to investigate the effect of nimodipine and treatment initiation timing on the prevention of worsened vasoconstriction.MethodsWe prospectively recruited patients with recent-onset (within 3 weeks of the first thunderclap headache), angiogram-proven RCVS. All participants underwent transcranial Doppler (TCD) examination to evaluate the mean flow velocities (MFVs) of the bilateral middle cerebral arteries at baseline and were serially followed-up after 10, 20, 30, and 90 days. Oral nimodipine treatment was initiated after the baseline TCD study, and patients were split into early and late treatment groups based on the time from onset to initial nimodipine administration. To estimate the worsening of vasoconstriction, we calculated the area of total time spent with MFVs above the baseline value (“MFV area”). We tested the correlation between the number of days from onset to treatment initiation and MFV area and performed linear regression analysis to examine the independent association between earlier treatment and MFV area.ResultsA total of 32 patients with RCVS (mean age: 51.5 ± 10.3 years; 91% female) completed this study. Baseline TCD assessment was performed at a mean of 7.1 ± 4.2 days after thunderclap headache onset. We observed that earlier treatment with nimodipine correlated with reduced MFV area (r = 0.37,p= 0.038). Furthermore, this association remained significant after adjusting for other clinical variables (regression coefficient 0.673, adjustedp= 0.023) in the multivariable linear regression.ConclusionsEarly oral nimodipine treatment prevents worsening of vasoconstriction, suggesting that nimodipine may have a disease-modifying effect in RCVS treatment.