bluuebunny/crossref_metadata_2025_split huggingface dataset:
High incidence of progressive postnatal cerebellar enlargement in Costello syndrome: Brain overgrowth associated with HRAS mutations as the likely cause of structural brain and spinal cord abnormalities
Authors: Gripp Karen W. , Hopkins Elizabeth , Doyle Daniel , Dobyns William B. 
Published: April 2010

AbstractCostello syndrome is a rasopathy caused by germline mutations in the proto‐oncogene HRAS. Its presentation includes failure‐to‐thrive with macrocephaly, characteristic facial features, hypertrophic cardiomyopathy, papillomata, malignant tumors, and cognitive impairment. In a systematic review we found absolute or relative macrocephaly (100%), ventriculomegaly (50%), and other abnormalities on brain and spinal cord imaging studies in 27/28 individuals. Posterior fossa crowding with cerebellar tonsillar herniation (CBTH) was noted in 27/28 (96%), and in 10/17 (59%) with serial studies posterior fossa crowding progressed. Sequelae of posterior fossa crowding and CBTH included hydrocephalus requiring shunt or ventriculostomy (25%), Chiari 1 malformation (32%), and syrinx formation (25%). Our data reveal macrocephaly with progressive frontal bossing and CBTH, documenting an ongoing process rather than a static congenital anomaly. Comparison of images obtained in young infants to subsequent studies demonstrated postnatal development of posterior fossa crowding. This process of evolving megalencephaly and cerebellar enlargement is in keeping with mouse model data, delineating abnormal genesis of neurons and glia, resulting in an increased number of astrocytes and enlarged brain volume. In Costello syndrome and macrocephaly‐capillary malformation syndrome disproportionate brain growth is the main factor resulting in postnatal CBTH and Chiari 1 malformation. © 2010 Wiley‐Liss, Inc.
Genetic counseling of adults with Williams syndrome: A first study
Authors: Farwig Katrina , Harmon Amanda G. , Fontana Kristina M. , Mervis Carolyn B. , Morris Colleen A. 
Published: April 2010

AbstractWe report on a study of genetic counseling to 43 adults with Williams syndrome (WS). Participants were initially asked what they knew about how WS occurs. Genetic counseling was provided with a focus on the basic genetics of WS, recurrence risk, and on participants' attitudes toward socio‐cultural topics. Forty‐nine percent indicated that they would be okay or happy if their baby had WS, 44% said they would be sad or upset, and 5% were unsure. The sad/upset group was significantly older than the okay/happy group and a significantly higher proportion of the former group indicated that they did not plan to have children. During the post‐counseling session participants were questioned to determine if they recalled the facts previously presented. Eighty‐one percent correctly gave the odds that their child would have WS. Fifty‐three percent considered the 50–50 odds to be a high chance. After genetic counseling, 61% were able to state something that had been taught and 88% indicated that they would want to test their baby for WS before birth. Ninety‐eight percent would recommend genetic counseling to others. Findings indicate that based on the type of genetic counseling provided in this study, the majority of individuals with WS—a genetic disorder associated with intellectual disability but with relative strengths in (concrete) language and in verbal rote memory—are able to learn simple facts about the genetics of WS and are eager to respond to socio‐cultural questions regarding topics typically included in genetic counseling sessions. © 2010 Wiley‐Liss, Inc.
pH‐Dependent conjugate addition of arylboronic acids to α,β‐unsaturated enones catalyzed by a reusable palladium(II)/cationic 2,2′‐bipyridyl system in water under air
Authors: Huang Shao‐Hsien , Wu Tzu‐Min , Tsai Fu‐Yu 
Published: April 2010

AbstractA reusable Pd(NH3)2Cl2/cationic 2,2′‐bipyridyl system for the catalysis of the conjugate addition of arylboronic acids to α,β‐unsaturated enones in water under air was developed. Addition of arylboronic acids to both cyclic and acyclic enones progressed smoothly, providing the products in good to high yields, the best result being obtained when HBF4 was used to adjust the pH value to 1.0. After the reaction, the residual aqueous solution could be reused several times, making the reaction greener and reducing wastage of precious metals. Copyright © 2010 John Wiley & Sons, Ltd.
Uterine and Placental Angiogenesis in the Australian Skinks, Ctenotus taeniolatus, and Saiphos equalis
Authors: Parker Scott L. , Manconi Frank , Murphy Christopher R. , Thompson Michael B. 
Published: April 2010

AbstractThe evolution of viviparity requires modifications to multiple integrated physiological features to support embryonic development during pregnancy. Embryonic growth during pregnancy is dependent upon the capacity of the uterine vascular system to satisfy increasing embryonic oxygen demand throughout gestation. We tested the hypothesis that total surface area of uterine blood vessels increases in concert with embryonic growth, and hence its oxygen demand, during gestation. We used immunofluorescence and laser‐scanning confocal microscopy to quantify uterine microvascular density and morphology during gestation in the oviparous skink Ctenotus taeniolatus and in Saiphos equalis, a skink species with prolonged egg retention. For C. taeniolatus, vessel density (Nv) and vessel length‐density (Lv) in the embryonic hemisphere of the uterus is 23% and 17% less, respectively, than that of S. equalis and vascular surface‐area does not differ as a function of embryo stage. For S. equalis, overall Nv, Lv, and vessel diameter (Dv), does not change during the first half of gestation but increases by 36% (Nv), 44% (Lv), and 60% (Dv) by near‐term embryo stages late in gestation. The chorioallantoic membrane of S. equalis increases in absolute size but vascular density does not differ as a function of embryo stage. The marked increase in uterine vascular density during late gestation coincides with the phase of rapid growth in embryo mass and concomitant increase in metabolic rate. Expansion of the uterine vascular bed in concert with embryo size and metabolism is likely to be an important transitional step in the evolution of viviparity. Anat Rec, 293:829–838, 2010. © 2010 Wiley‐Liss, Inc.
Atypical Fetal Prostate Development is Associated with Ipsilateral Hypoplasia of the Wolffian Ducts in the ACI Rat
Authors: Hofkamp Luke E. , Bradley Sarahann , Geliebter Jan , Timms Barry G. 
Published: April 2010

AbstractSerial section reconstruction images of the male ACI rat urogenital sinus shown from a dorso‐cranial view. The image in the lower right illustrates the normal late gestation appearance of the accessory gland development, compared to the Wolffian duct ipsilateral abnormality observed in 25% of the male offspring (upper left). See Potok et al., Anatomical Record 239:747–753.
Die Elektrochemische Reduktion von M‐Nitroacetophenon und M‐Nitrobenzophenon
Authors: Elbs K. , Wogrins A. 
Published: April 2010

Abstract
m‐Nitroacetophenon lasst sich nach bekannten Verfahren leicht zum m‐Azoacetophenon und zum m‐Aminoacetophenon elektrochemisch reduzieren. die Versuche zur Darstellung von m‐Azoxyacetophenon lieferten stets Gemische von Azoxy‐ und Azoverbindung; die Reduktion zur Hydrazoverbindung und deren Umlagerung in das entsprechende Benzidin gelingen nur mangelhaft.
m‐Nitrobenzophenon liefert bei der elektrochemischen Reduktion in sehr guter Ausbeute m‐Azoxybenzophenon, m‐Azobenzophenon und m‐Aminobenzophenon. Die Hydrazoverbindung ist sehr leicht oxydierbar und das daraus durch Umlagerung erhaltene Benzidin hat für die Reinigung ungünstige Eigenschaften.
Bei keinem der verschiedenen, zur Reduktion der Nitrogruppe benutzten elektrochemischen Verfahren liess sich eine Beteiligung der Carbonylgruppe an der Reduktion nachweisen.
Giessen, im April 1903.Physikalisch‐Chemisches Universitätslaboratorium.
Bücherschau
Authors: Lottermoser Lottermoser  
Published: April 2010

AbstractKolloides Silber und die Photohaloide. Von Carey Lea. In deutscher Uebersetzung mit Anmerkungen neu herausgegeben von Dr. Lüppo‐Cramer. Verlag von Theodor Steinkopff, Dresden. Preis 4 Mk., geb. 4,80 Mk.Kolloidchemie und Photographie. Von Dr. Lüppo‐Cramer. Verlag von Theodor Steinkopff, Dresden. Preis 5 Mk., geb. 5,80 Mk.B. G. Teubners Handbücher: Für Handel und Gewerbe. Herausgegeben von Präsident Dr. van der Borght‐Berlin, Prof. Dr. Schuhmacher‐Bonn und Regierungsrat Dr. Stegemann ‐ Braunschweig. Ein‐führung in die Elektrotechnik. Physikalische Grundlagen und technische Ausführungen. Von R. Rickel (Professor an der Handels‐Hochschule Köln). 445 Abbildungen im Text. 463 Seiten. Leipzig 1908. Verlag von Teubner. Preis geh. 11,20 Mk., geb. 12 Mk.
Speciation through cytonuclear incompatibility: Insights from yeast and implications for higher eukaryotes
Authors: Chou Jui‐Yu , Leu Jun‐Yi 
Published: April 2010

AbstractSeveral features of the yeast mitochondrial genome, including high mutation rate, dynamic genomic structure, small effective population size, and dispensability for cellular viability, make it a promising candidate for generating hybrid incompatibility and driving speciation. Cytonuclear incompatibility, a specific type of Dobzhansky‐Muller genetic incompatibility caused by improper interactions between mitochondrial and nuclear genomes, has previously been observed in a variety of organisms, yet its role in speciation remains obscure. Recent studies in Saccharomyces yeast species provide a new insight, with experimental evidence that cytonuclear incompatibility and DNA sequence divergence are both causes of the reproductive isolation of different yeast species. Interestingly, these two mechanisms seem to be perfectly complementary to each other in terms of their effects and evolutionary trajectories. Direct molecular analyses of the incompatible genes in yeasts have started to shed light on the evolutionary forces driving speciation. Editor's suggested further reading in BioEssaysThe cytoplasmic structure hypothesis for ribosome assembly, vertical inheritance, and phylogeny AbstractMitochondrial bioenergetics as a major motive force of speciation Abstract
Cell damage evaluation of thermal inkjet printed Chinese hamster ovary cells
Authors: Cui Xiaofeng , Dean Delphine , Ruggeri Zaverio M. , Boland Thomas 
Published: April 2010

AbstractThermal inkjet printing technology has been applied successfully to cell printing. However, there are concerns that printing process may cause cell damages or death. We conducted a comprehensive study of thermal inkjet printed Chinese hamster ovary (CHO) cells by evaluating cell viability and apoptosis, and possible cell membrane damages. Additionally, we studied the cell concentration of bio‐ink and found optimum printing of concentrations around 8 million cells per mL. Printed cell viability was 89% and only 3.5% apoptotic cells were observed after printing. Transient pores were developed in the cell membrane of printed cells. Cells were able to repair these pores within 2 h after printing. Green fluorescent protein (GFP) DNA plasmids were delivered to CHO‐S cells by co‐printing. The transfection efficiency is above 30%. We conclude that thermal inkjet printing technology can be used for precise cell seeding with minor effects and damages to the printed mammalian cells. The printing process causes transient pores in cell membranes, a process which has promising applications for gene and macroparticles delivery to induce the biocompatibility or growth of engineered tissues. Biotechnol. Bioeng. 2010;106: 963–969. © 2010 Wiley Periodicals, Inc.
Quantitative HPLC method and pharmacokinetic studies of ergosta‐4,6,8(14),22‐tetraen‐3‐one, a natural product with diuretic activity from Polyporus umbellatus
Authors: Zhao Ying‐Yong , Qin Xiang‐Yang , Zhang Yongmin , Lin Rui‐Chao , Sun Wen‐Ji , Li Xiao‐Ye 
Published: April 2010

AbstractA simple and specific HPLC method with dual wavelength UV detection for the determination of ergosta‐4,6,8(14),22‐tetraen‐3‐one (ergone) in rat plasma was developed and proved to be efficient. The method used ergosterol as internal standard (IS). Following a single‐step protein precipitation, the analyte and IS were separated on an Inertsil ODS‐3 column with a mobile phase containing methanol–water (99:1, v/v) at a flow rate of 1 mL/min. The analytes were detected by using UV detection at wavelength of 350 (ergone) and 283 (IS) nm, respectively. The calibration curve was linear over the range of 0.1–2.0 µg/mL and the lower limit of quantification was 0.1 µg/mL. The intra‐day and inter‐day precision studies showed good reproducibility with RSD less than 8.5%. The intra‐day and inter‐day accuracy ranged from 95.6 to 104%. Mean extraction recovery was above 95% at the low, medium and high concentrations. The present HPLC‐UV method was simple and reliable. The method described herein had been successfully applied for the pharmacokinetic studies in male SD rats after administration of 20 mg/kg dose of solution of ergone. Copyright © 2010 John Wiley & Sons, Ltd.
Ionic Liquids for Chloromethane/Isobutane Distillative Separation: Express Screening
Authors: Mokrushin V. , Mokrushina L. , Arlt W. , Assenbaum D. , Wasserscheid P. , Petri M. , Wewers W. 
Published: April 2010

AbstractThe present study centres on room‐temperature ionic liquids (ILs) as entrainers in extractive distillation of chloromethane/isobutane mixtures. The binary system, chloromethane/isobutene, is an azeotropic system. In this study, IL entrainers are shown to be able to break the azeotrope and, thus, assure the separation in the whole range of chloromethane/isobutane ratios. ILs formed from different cations and anions are considered and their influence on chloromethane/isobutane separation is explored. Among the ILs studied, those containing the trifluoromethanesulfonate ([CF3SO3]–) or tricyanomethanide ([C(CN)3]–) anion are demonstrated to exhibit an enhanced potential for chloromethane/isobutane separation compared to the corresponding ILs based on the bis(trifluoromethylsulfonyl)imide ([Tf2N]–) anion. Moreover, the ILs enclosing these anions are cheaper than those with the [Tf2N]– anion. Thus, the separation ability, solubility of chloromethane/isobutane mixtures, and costs of IL entrainers can be adjusted by the right choice of cations and anions.
Ligand Association/Dissociation Paths and Ill‐Defined Coordination Numbers
Authors: Ruiz‐Martínez Antonio , Casanova David , Alvarez Santiago 
Published: April 2010

AbstractThe continuous shape measures approach provides a means for handling the common situation in which a metal atom presents an ill‐defined coordination number. Those cases are characterized by the presence of secondary interactions to Lewis bases at distances significantly longer than those expected for a chemical bond. Systematic ways of analyzing ligand association/dissociation pathways that describe such structures and their application to a variety of specific cases are presented. The concepts and methodology presented here apply to molecules and extended solids as well and provide, when needed, a more flexible and precise stereochemical description of the metal coordination sphere than that of an integer coordination number and the associated polyhedral shape.
ChemInform Abstract: La1‐xCexCrO3 (0.0 ≤ x ≤ 1.0): A New Series of Solid Solutions with Tunable Magnetic and Optical Properties.
Authors: Shukla Rakesh , Manjanna Jayappa , Bera Anup K. , Yusuf Seikh M. , Tyagi Avesh K. 
Published: April 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Quaternary Neptunium Compounds: Syntheses and Characterization of KCuNpS3, RbCuNpS3, CsCuNpS3, KAgNpS3, and CsAgNpS3.
Authors: Wells Daniel M. , Jin Geng Bang , Skanthakumar S. , Haire Richard G. , Soderholm L. , Ibers James A. 
Published: April 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Fe5O5 [B6O10(OH)3]·nH2O: Wave‐Layered Iron Borate and Frustrated Antiferromagnetism.
Authors: Yang Tao , Sun Junliang , Li Guobao , Wang Yingxia , Christensen Jeppe , He Zhanbing , Christensen Kirsten E. , Zou Xiaodong , Liao Fuhui , Lin Jianhua 
Published: April 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Organocatalyzed Michael—Michael Cascade Reaction Generates Highly Substituted Fused Carbocycles.
Authors: McGarraugh Patrick G. , Brenner Stacey E. 
Published: April 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Microwave Assisted One‐Pot Synthesis of 2‐Amino‐4H‐chromenes and Spiropyrano[2,3‐d]pyrimidine.
Authors: Mahmoud Alaa F. , Abd El‐Latif Fathy F. , Ahmed Amira M. 
Published: April 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Propargyl Amine Synthesis Catalyzed by Gold and Copper Thin Films by Using Microwave‐Assisted Continuous‐Flow Organic Synthesis (MACOS).
Authors: Shore Gjergji , Yoo Woo‐Jin , Li Chao‐Jun , Organ Michael G. 
Published: April 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Enantioselective Ketone‐Ene Reactions of Trifluoropyruvate: Significant Counterion Effect of the In(III)—PyBox Complex.
Authors: Zhao Jun‐Feng , Tjan Teguh‐Budiono W. , Tan Boon‐Hong , Loh Teck‐Peng 
Published: April 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cyclopentadienyl‐Free Rare‐Earth Metal Amides [{(CH2SiMe2){ (2,6‐iPr2C6H3)N}2}Ln{N (SiMe3)2}(THF)] as Highly Efficient Versatile Catalysts for C—C and C—N Bond Formation.
Authors: Wu Yunjun , Wang Shaowu , Zhang Lijun , Yang Gaosheng , Zhu Xiancui , Zhou Zhihong , Zhu Hong , Wu Shihong 
Published: April 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: One‐Pot Synthesis of 2‐(2‐Alkoxy‐5‐amino‐4‐cyano‐2‐methylfuran‐3(2H)‐ylidene)malononitriles.
Authors: Bardasov I. N. , Kayukova O. V. , Kayukov Ya. S. , Ershov O. V. , Belikov M. Yu. , Nasakin O. E. 
Published: April 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 3,4‐Fused Bicyclic β‐Lactams and Their Transformation into Methyl cis‐3‐Aminotetrahydrofuran‐2‐carboxylates.
Authors: Leemans Erika , D'hooghe Matthias , Dejaegher Yves , Toernroos Karl W. , De Kimpe Norbert 
Published: April 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel Three‐Component Domino Reactions of Ketones, Isatin and Amino Acids: Synthesis and Discovery of Antimycobacterial Activity of Highly Functionalized Novel Dispiropyrrolidines.
Authors: Kumar Raju Suresh , Rajesh Stephen Michael , Perumal Subbu , Banerjee Debjani , Yogeeswari Perumal , Sriram Dharmarajan 
Published: April 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient Synthesis of N‐Arylsulfonylindoles from Indoles and Arylsulfonyl Chlorides in the Presence of Triethylbenzylammonium Chloride (TEBA) and NaOH.
Authors: Xu Hui , Wang Yangyang 
Published: April 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Facile Synthesis of 3,3‐Diallyl Isoindolones via an Indium‐Mediated Double Allylation of ortho‐Cyanobenzoates.
Authors: Kim Sung Hwan , Kim Se Hee , Kim Ko Hoon , Kim Jae Nyoung 
Published: April 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Convenient Synthesis of 1,5‐Diarylpyrazoles from Baylis—Hillman Adducts Using HY‐Zeolite.
Authors: Nikpassand Mohammad , Mamaghani Manouchehr , Zanjanchi Mohammad Ali , Mahmoodi Nosrat Olah , Mirzaeinejad Massomeh 
Published: April 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Synthesis of 5,6‐Dihydrothiazolo[3,2‐b][1,2,4]triazoles.
Authors: Klen E. E. , Khaliullin F. A. 
Published: April 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.