bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ranibizumab for Eyes Previously Treated With Pegaptanib or Bevacizumab Without Clinical Response
Authors: Kaiser Richard S. , Gupta Omesh P. , Regillo Carl D. , Ho Allen C. , Fineman Mitchell S. , Vander James F. , McNamara J. Arch , Brown Gary C. 
Published: October 2011

BACKGROUND AND OBJECTIVE:
To assess the safety and efficacy of ranibizumab in patients who had inadequate response to pegaptanib or bevacizumab.

PATIENTS AND METHODS:
In this single-center study, 19 patients with subfoveal choroidal neovascularization secondary to age-related macular degeneration (AMD) previously treated with pegaptanib (n = 1), bevacizumab (n = 13), or both (n = 5) received 12 monthly ranibizumab injections (0.5 mg). Outcomes were measured from start of previous therapy (baseline) to start of ranibizumab treatment (day 0) through 12 months.

RESULTS:
No drug- or injection-related adverse events and no serious adverse events were reported. At 6 and 12 months, 4 and 5 patients gained 3 or more lines of VA, respectively; 3 patients lost less than 3 lines of VA at 6 months, and 6 patients lost less than 3 lines at 12 months. At 6 and 12 months, VA increased by a mean (± standard error of the mean) of 2.06 ± 1.23 and 1.17 ± 0.62 lines, respectively. Central retinal thickness decreased by a mean of 62.65 ± 22.46 and 62.16 ± 29.20 μm at months 6 and 12, respectively. When stratified by pigment epithelial detachment (PED) status, patients without PED had better visual and anatomical outcomes than patients with PED.

CONCLUSION:
Ranibizumab has favorable safety and efficacy profiles for patients with AMD without previous response to pegaptanib or bevacizumab.
Sociotechnical Challenges of Developing an Interoperable Personal Health Record
Authors: Longhurst C.A. , Slayton R. , Das A.K. , Gaskin G.L. 
Published: October 2011

SummaryObjectives: To analyze sociotechnical issues involved in the process of developing an interoperable commercial Personal Health Record (PHR) in a hospital setting, and to create guidelines for future PHR implementations.Methods: This qualitative study utilized observational research and semi-structured interviews with 8 members of the hospital team, as gathered over a 28 week period of developing and adapting a vendor-based PHR at Lucile Packard Children’s Hospital at Stanford University. A grounded theory approach was utilized to code and analyze over 100 pages of typewritten field notes and interview transcripts. This grounded analysis allowed themes to surface during the data collection process which were subsequently explored in greater detail in the observations and interviews.Results: Four major themes emerged: (1) Multidisciplinary teamwork helped team members identify crucial features of the PHR; (2) Divergent goals for the PHR existed even within the hospital team; (3) Differing organizational conceptions of the end-user between the hospital and software company differentially shaped expectations for the final product; (4) Difficulties with coordination and accountability between the hospital and software company caused major delays and expenses and strained the relationship between hospital and software vendor.Conclusions: Though commercial interoperable PHRs have great potential to improve healthcare, the process of designing and developing such systems is an inherently sociotechnical process with many complex issues and barriers. This paper offers recommendations based on the lessons learned to guide future development of such PHRs.
Ice‐Mediated Reactions and Assemblies in Diverse Domains
Authors: Wang Dan , Wu Jiahui , Wu Shaojun , Chen Xiaoting , Li Wei , Chen Xiaofei , Gao Chong , He Zhiyuan 
Published: June 2024

AbstractIn chemistry, biology, and materials science, ice‐mediated reactions and ice‐template assembly techniques are garnering increasing attention due to their unique advantages. Such approaches not only offer deep insights into the fundamental roles of ice in nature but also pave new avenues for various applications. This review comprehensively explores the mechanisms and applications of ice‐mediated reactions and assembly. It begins by examining the principles of ice‐mediated reactions, particularly how certain chemical reactions are accelerated in the micro‐environment of ice through freeze‐concentration and freeze‐potential effects, and the relationship between the surface structure and properties of ice and chemical reactions. This work then studies significant chemical reactions within the realms of environmental, biological, and materials science engineering, shedding light on the role of ice in these reactions. Furthermore, this work explores the fundamentals of ice templating in material assembly, describe the main ice‐templating methods, and highlight the ice‐templated materials along with their diverse applications. This work concludes by summarizing the prospective challenges and untapped potentials in the field of ice‐mediated reactions and assembly. This review not only accentuates the transformative impact of ice‐mediated techniques in scientific domains but also serves as an useful guide for future research initiatives and practical applications in this burgeoning field.
A 2D Porous Cu3N Catalyst for Efficient CO Electroreduction to Multicarbon Products at an Ampere Level Current Density
Authors: Cheng Liming , He Dayin , Ma Xianhui , Deng Hongfan , Ruan Yaner , Sun Rongbo , Tian Lin , Zhou Huang , Chen Jian , Wang Xinqiang , Pan Hongge , Guo Wenxin , Wu Yuen 
Published: June 2024

AbstractThe maturation of CO2 electrolysis to CO technology has rendered a cascade catalysis scheme, utilizing CO reduction as a media step, a promising strategy to produce high‐value C2+ fuel. However, the current catalysts employed in CO electroreduction (ECORR) face severe hydrogen evolution reactions at high current densities. Herein, a 2D porous Cu3N (2D‐P‐Cu3N) catalyst is reported with outstanding ECORR performance prepared by a two‐step pyrolysis strategy. This strategy mainly relies on the sequential annealing of the Cu2(OH)2CO3 precursors in an oxidation and reduction atmosphere, which can not only convert it into high‐purity Cu3N, but also endow it with an abundant hierarchical pores structure. The pores can significantly improve the in‐plane conductivity and mass transfer capacity of Cu3N, enabling a C2+ faradaic efficiency exceeding 90% at a current density of 0.6 A cm−2. Even at an ampere grade current density of 1 A cm−2, it maintains an impressive 87% selectivity, surpassing most of the reported Cu‐based catalysts. In‐situ Raman spectroscopy confirms that 2D‐P‐Cu3N exhibits high coverage and adsorption of CO intermediates, thus enhancing C‐C coupling and promoting the generation of C2+ products. This discovery opens further exploration of catalysts for selective CORR to C2+ products.
Achieving 19.78%‐Efficiency Organic Solar Cells by 2D/1A Ternary Blend Strategy with Reduced Non‐Radiative Energy Loss
Authors: Jiang Xiaolin , Wang Xiaodong , Wang Yifan , Ran Guangliu , Liu Wenlong , Lu Hao , Li Hongxiang , Wei Nan , Wei Zhengdong , Lin Yi , Ma Zaifei , Liu Yahui , Zhang Wenkai , Xu Xinjun , Bo Zhishan 
Published: June 2024

AbstractReducing non‐radiative energy loss (∆Enr) is critical for enhancing the photovoltaic performance of organic solar cells (OSCs). To achieve this, a small molecular donor, LJ1, is introduced as the third component in the host system D: A system (D18: BTP‐eC9‐4F). The cascade‐like energy level alignment of D18, LJ1, and BTP‐eC9‐4F facilitates efficient charge transfer. LJ1's good solubility in the processing solvent and high miscibility with BTP‐eC9‐4F delay the precipitation of BTP‐eC9‐4F, leading to improved phase morphology in blend films. Additionally, LJ1 increases spacing between the polymer donor (PD) and the small molecule acceptor (SMA), optimizing blend film morphology and reducing non‐radiative energy loss in OSCs. Ternary OSCs based on D18:LJ1:BTP‐eC9‐4F achieve a power conversion efficiency (PCE) of 19.43% with reduced ∆Enr. Notably, the ternary device using D18:LJ1:L8‐BO attains an outstanding PCE of 19.78%, which is one of the highest device efficiency for ternary OSC. The work highlights the effectiveness of the ternary blend strategy in enhancing OSC performance while minimizing ∆Enr.
Dynamic Covalent Hydrogel as a Single‐Dose Vaccine Adjuvant for Sustained Antigen Release and Significantly Elevated Humoral Immunity
Authors: Shi Zhiyuan , Gao Zihan , Zhuang Xinyu , Si Xinghui , Huang Zichao , Di Yaxin , Ma Sheng , Guo Zhaopei , Li Chang , Jin Ningyi , Huang Leaf , Tian Mingyao , Song Wantong , Chen Xuesi 
Published: June 2024

AbstractVaccine is the most important way for fighting against infection diseases. However, multiple injections and unsatisfied immune responses are the main obstacles for current vaccine application. Herein, a dynamic covalent hydrogel (DCH) is used as a single‐dose vaccine adjuvant for eliciting robust and sustained humoral immunity. By adjusting the mass ratio of the DCH gel, 10–30 d constant release of the loaded recombinant protein antigens is successfully realized, and it is proved that sustained release of antigens can significantly improve the vaccine efficacy. When loading SARS‐CoV‐2 RBD (Wuhan and Omicron BA.1 strains) antigens into this DCH gel, an over 32 000 times and 8000 times improvement is observed in antigen‐specific antibody titers compared to conventional Aluminum adjuvanted vaccines. The universality of this DCH gel adjuvant is confirmed in a Nipah G antigen test as well as a H1N1 influenza virus antigen test, with much improved protection of C57BL/6 mice against H1N1 virus infection than conventional Aluminum adjuvanted vaccines. This sustainably released, single‐dose DCH gel adjuvant provides a new promising option for designing next‐generation infection vaccines.
Multifaceted Hydrogel Scaffolds: Bridging the Gap between Biomedical Needs and Environmental Sustainability
Authors: Mamidi Narsimha , De Silva Fátima Franco , Vacas Alejandro Bedón , Gutiérrez Gómez Javier Adonay , Montes Goo Naomi Yael , Mendoza Daniela Ruiz , Reis Rui L. , Kundu Subhas C. 
Published: June 2024

AbstractHydrogels are dynamically evolving 3D networks composed of hydrophilic polymer scaffolds with significant applications in the healthcare and environmental sectors. Notably, protein‐based hydrogels mimic the extracellular matrix, promoting cell adhesion. Further enhancing cell proliferation within these scaffolds are matrix‐metalloproteinase‐triggered amino acid motifs. Integration of cell‐friendly modules like peptides and proteins expands hydrogel functionality. These exceptional properties position hydrogels for diverse applications, including biomedicine, biosensors, environmental remediation, and the food industry. Despite significant progress, there is ongoing research to optimize hydrogels for biomedical and environmental applications further. Engineering novel hydrogels with favorable characteristics is crucial for regulating tissue architecture and facilitating ecological remediation. This review explores the synthesis, physicochemical properties, and biological implications of various hydrogel types and their extensive applications in biomedicine and environmental sectors. It elaborates on their potential applications, bridging the gap between advancements in the healthcare sector and solutions for environmental issues.
Graphene‐Perovskite Fibre Photodetectors
Authors: Akhavan S. , Najafabadi A. Taheri , Mignuzzi S. , Jalebi M. Abdi , Ruocco A. , Paradisanos I. , Balci O. , Andaji‐Garmaroudi Z. , Goykhman I. , Occhipinti L. G. , Lidorikis E. , Stranks S. D. , Ferrari A. C. 
Published: June 2024

AbstractThe integration of optoelectronic devices, such as transistors and photodetectors (PDs), into wearables and textiles is of great interest for applications such as healthcare and physiological monitoring. These require flexible/wearable systems adaptable to body motions, thus materials conformable to non‐planar surfaces, and able to maintain performance under mechanical distortions. Here, fibre PDs are prepared by combining rolled graphene layers and photoactive perovskites. Conductive fibres (~500 Ωcm‐1) are made by rolling single‐layer graphene (SLG) around silica fibres, followed by deposition of a dielectric layer (Al2O3 and parylene C), another rolled SLG as a channel, and perovskite as photoactive component. The resulting gate‐tunable PD has a response time~9ms, with an external responsivity~22kAW‐1 at 488nm for a 1V bias. The external responsivity is two orders of magnitude higher, and the response time one order of magnitude faster, than state‐of‐the‐art wearable fibre‐based PDs. Under bending at 4mm radius, up to~80% photocurrent is maintained. Washability tests show~72% of initial photocurrent after 30 cycles, promising for wearable applications.
Protruding‐Shaped Co Polarization Field on Ultrathin Covalent Triazine Framework Nanosheets for Efficient CO2 Photoreduction
Authors: Ma Zhixue , Yin Huang , Lyu Pengbo , Xu Yuxi 
Published: June 2024

AbstractSingle‐atom photocatalysts (SAPs) engineered on various supports offer a promising pathway to efficiently convert CO2 into high‐valued products. However, most SAPs with near‐planar metal atom coordination structure suffer from low conversion efficiency, mainly due to the weak local polarized electric field which retards the reaction kinetics. Herein, this study reports for the first time a photocatalyst which simultaneously integrates protruding‐shaped Co single atom and strong polarization field in ultrathin crystalline covalent‐triazine‐framework nanosheets (donate as Co1/CTF‐NSs). Both experimental results and theoretical simulations demonstrated that giant local polarization field is successfully triggered on the Co1/CTF‐NSs, which induced directional charge migration and greatly promoted the separation of photogenerated carriers. The protruding‐Co centers enhanced the overlap between CO2 2p and Co 3d orbitals, thereby facilitating a strong affinity for CO2 adsorption. Furthermore, the local polarization fields between the protruding‐Co and CO2 drove the injection of a substantial number of electrons from Co 3d into CO2 π antibonding orbitals, leading to the effective activation and reduction of the CO2 molecules. Consequently, the as‐synthesized Co1/CTF‐NSs exhibited a remarkable CO production rate of 5391 µmol g−1 h−1 and a high selectivity (97.3%) under visible light irradiation, which represents one of the best molecular framework photocatalysts to date.
Multi‐strategy Grey Wolf Optimizer for Engineering Problems and Sewage Treatment Prediction
Authors: Tang Chenhua , Huang Changcheng , Chen Yi , Heidari Ali Asghar , Wang Shuihua , Chen Huiling , Zhang Yudong 
Published: June 2024

Grey wolf optimizer (GWO) is a highly valued heuristic algorithm in many fields. However, for some complex problems, especially high‐dimensional and multimodal problems, the basic algorithm has limited computational power and cannot get a satisfactory answer. In order to find a better solution, an improved algorithm based on GWO is proposed herein. Gaussian barebone, random selection and chaotic game mechanisms are introduced into the GWO algorithm to enhance the global search ability. The GWO enhanced by three mechanisms is called CBRGWO. To verify the performance of CBRGWO, using IEEE CEC 2017 as a test function, CBRGWO is compared to five GWO variants, five basic algorithms, six advanced algorithms, and four champion algorithms. CBRGWO is evaluated using the Friedman test and Wilcoxon signed‐rank test. Then, the stability of CBRGWO is analyzed. To verify that CBRGWO is still effective in practical application, CBRGWO is applied to five engineering problems and a water quality prediction problem. The experimental findings indicate that CBRGWO maintains excellent optimization ability in practical engineering problems.
A Bioinspired Robotic Finger for Multimodal Tactile Sensing Powered by Fiber Optic Sensors
Authors: Mao Baijin , Zhou Kunyu , Xiang Yuyaocen , Zhang Yuzhu , Yuan Qiangjing , Hao Hongwei , Chen Yaozhen , Liu Houde , Wang Xueqian , Wang Xiaohao , Qu Juntian 
Published: June 2024

The rapid advancement of soft robotic technology emphasizes the growing importance of tactile perception. Soft grippers, equipped with tactile sensing, can gather interactive information crucial for safe human–robot interaction, wearable devices, and dexterous manipulation. However, most soft grippers with tactile sensing abilities have limited modes of tactile perception, restricting their dexterity and safety. In addition, existing tactile systems are often complicated, leading to unstable perception signals. Inspired by various organisms, a novel multimodal tactile‐sensing soft robotic finger is proposed. This finger, based on a modified fin ray structure, integrates a distributed fiber optic sensing system as part of its tactile sensory neural system. It replicates human finger capabilities, discerning contact forces as low as 0.01 N with exceptional sensitivity (106.96 mN nm−1). Through training neural networks models, the finger achieves an accuracy exceeding 96% in recognizing roughness, material stiffness, and finger pad position. Assembled into two‐finger parallel gripper, it demonstrates precise manipulation capabilities for fragile items like strawberries and potato chips. Moreover, through synergistic interplay of multimodal tactile sensing, this finger can successfully grasp an underwater transparent sphere, mitigating limitations of visual perception. The developed soft finger holds promise in various scenarios including hazardous environment detection and specialized grasping tasks.
Crosstalk between bone and brain in Alzheimer's disease: Mechanisms, applications, and perspectives
Authors: Liu Zhuo‐Ting , Liu Ming‐Han , Xiong Yan , Wang Yan‐Jiang , Bu Xian‐Le 
Published: June 2024

AbstractAlzheimer's disease (AD) is a neurodegenerative disease that involves multiple systems in the body. Numerous recent studies have revealed bidirectional crosstalk between the brain and bone, but the interaction between bone and brain in AD remains unclear. In this review, we summarize human studies of the association between bone and brain and provide an overview of their interactions and the underlying mechanisms in AD. We review the effects of AD on bone from the aspects of AD pathogenic proteins, AD risk genes, neurohormones, neuropeptides, neurotransmitters, brain‐derived extracellular vesicles (EVs), and the autonomic nervous system. Correspondingly, we elucidate the underlying mechanisms of the involvement of bone in the pathogenesis of AD, including bone‐derived hormones, bone marrow‐derived cells, bone‐derived EVs, and inflammation. On the basis of the crosstalk between bone and the brain, we propose potential strategies for the management of AD with the hope of offering novel perspectives on its prevention and treatment.Highlights
The pathogenesis of AD, along with its consequent changes in the brain, may involve disturbing bone homeostasis.
Degenerative bone disorders may influence the progression of AD through a series of pathophysiological mechanisms.
Therefore, relevant bone intervention strategies may be beneficial for the comprehensive management of AD.
Molecular detection and association of 12.1 kb deletion within the high mobility AT‐hook 2 gene in the Netherlands dwarf rabbit (Oryctolagus Cuniculus)
Authors: Nguyen Tai Duc , Van Dang Lam , Tran Phuong Nhu Nguyen , Van Nguyen Dai , Bui Anh Phu Nam 
Published: June 2024

AbstractRabbits are mainly bred for human consumption and medical research. However, it has been recently showed that several rabbit breeds are also kept as pets for human leisure. The Netherlands dwarf rabbit is currently in the immense interest of many Vietnamese customers due to its personality and miniature stature. However, 12.1 kb deletion from position 44,709,089 to 44,721,236 bp in the high mobility AT‐hook 2 (HMGA2) gene on chromosome 4 was identified as the structural variant causing dwarfism and altered craniofacial development in this breed. It has been documented that HMGA2 plays an important role in regulating growth and individuals with genotype HMGA2 del/del are fatal several days after birth. Despite the economically high value of the Netherlands dwarf rabbit, there has been no study on the genetic survey of lethal alleles in this breed in Vietnam. The aim of this study is to develop a fast and reliable method to screen the frequency of lethal alleles of HMGA2 in the South of Vietnam. Rabbit saliva was collected, and DNA extraction was followed. Multiplex polymerase chain reaction (PCR) with three primers was optimized and performed to detect the presence of 12.1 kb deletion within the HMGA2 sequence. Our data showed that the 12.1 kb deletion in the Netherlands dwarf rabbit population was detected by our optimized multiplex PCR. In 100 rabbit animals, 34 and 16 individuals were homozygous wild type (+/+) and homozygous mutant (del/del), respectively, while 50 rabbits were heterozygous. The frequency of HMGA2 lethal allele carrier was 66% (66/100 individuals). Our results indicated that we successfully developed a fast, accurate multiplex PCR to detect carrier individuals. Verification of the genotypes was followed by sequencing. We recommend implementing our multiplex PCR procedure in genetic selection for carrier and homozygous wild‐type animals in the mating scheme to prevent the lethality of the rabbit offspring. Additionally, awareness should be raised among rabbit breeders to monitor the genetic makeup of the Netherlands dwarf rabbit populations. However, due to the limitation of the sample size, more samples should be taken in future studies to obtain the genetic frequency of the HMGA2 lethal allele more accurately.
Online psychological support in the COVID‐19 era: Social representations, trust and perceived effectiveness from the perspectives of clients and professionals
Authors: Colì Elisa , Gavrila Loredana , Cozzo Dacia , Falcone Rino 
Published: June 2024

AbstractBackgroundThis study examined the topic of online psychological counselling, focusing on the perspectives of both clients and professionals. In light of the widespread adoption of computer‐mediated psychological support during the COVID‐19 pandemic, the research analysed how it has taken shape in the collective consciousness, the role of trust, and perceived effectiveness.MethodThe sample consisted of 133 professionals (M = 46) and 716 patients (M = 33), recruited through non‐probabilistic snowball sampling. Data, collected through two ad hoc questionnaires, were analysed using the EVOC 2005 software (for social representations) and SPSS (for quantitative data).ResultsOverall, regarding the social representation of online psychological support, in the central core of the therapists' representation there seems to be a structured idea of the emotional distance that online therapy inevitably brings with it. In the core of the patients' representation, the idea of online support has been structured as a form of assistance that has shown its full usefulness during the pandemic.Quantitative data reveal a perceived efficacy of online psychological support comparable to in‐person therapy. Efficacy is enhanced by an already‐established trust relationship. The adoption of the online mode seems to have favoured the deployment of new resources by therapists and patients, attesting to an adaptation to this new way of conducting therapy. The online mode, in particular, will continue to be chosen by both, along with face‐to‐face meetings, as a mode of psychological support post‐pandemic.ConclusionBased on these findings, this study holds strong potential for practical application in the field of remote therapy.