bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effectiveness of Preventative Interventions to Reduce Mental Health Problems in at-risk Children and Young People: A Systematic Review of Reviews
Authors: McGovern R. , Balogun-Katung A. , Artis B. , Bareham B. , Spencer L. , Alderson H. , Brown E. , Brown J. , Lingam R. , McArdle P. , Newham J. J. , Wojciechowska A. , Rankin J. , Redgate S. , Thomason P. , Kaner E. 
Published: June 2024

AbstractMental health problems are the leading cause of childhood disability worldwide, resulting in poor outcomes for children and young people that persist into adulthood. It is essential that those young people most at risk of developing mental health problems receive effective preventative interventions. Whilst there have been a number of systematic reviews which have examined the effectiveness of secondary prevention interventions for specific groups of children and young people, or to address identified mental health concerns, no review has engaged with the breadth of this literature. We conducted a systematic review of systematic reviews to map this complex field of secondary preventative interventions and identify effective interventions to prevent mental health problems in children and adolescents aged 3–17 years. The review protocol was registered on PROSPERO. We searched five electronic databases from inception to February 2023. The certainty of the evidence was appraised using the AMSTAR 2. We included 49 unique systematic reviews each including between 2 and 249 (mean 34) unique studies; the majority of which were reviews which included only or mostly randomised controlled trials (70%). The reviews examined selective interventions (defined as interventions which are delivered to sub-group populations of young people at increased risk of mental health problems) (n = 22), indicated interventions (defined as interventions which target young people who are found to have pre-clinical symptoms) (n = 15) or a synthesis of both (n = 12). The certainty of the evidence in the reviews was rated as high, (n = 12) moderate (n = 5), low (n = 9) and critically low (n = 23). We found evidence to support both selective and indicated interventions in a range of populations and settings, with most of this evidence available for children and young people in their mid-years (6–10 years) and early adolescence (11–13 years). There was a large body of evidence suggesting that resilience enhancing, cognitive behaviour therapy-based and psychoeducational interventions for children who experience adversity, or those with subclinical externalising problems may offer promise. Early selective interventions for a subpopulation of children and young people who have experienced adversity which combines risk reduction and resilience enhancing approaches directed at children and their families may be effective at reducing mental health problems.
Release of elements and phenolic and flavonoid compounds from herbs and spices into acacia honey during infusion
Authors: Czipa Nikolett , Phillips Clive J. C. , Topa Emőke , Kovács Béla 
Published: June 2024

Abstract
Acacia honey was infused with basil, oregano, marjoram, dill, garlic or cinnamon at infusion rates of 0–5% by mass for a 6 months period. After removal of the infusates, macro and micro element concentrations were measured by Inductively Coupled Plasma Optical Emission Spectrometry. Total phenolic and flavonoid contents were determined spectroscopically. The greatest release of elements, phenols and flavonoids, (% release/1% infusion rate) were for phenols (1.22–3.74, respectively), flavonoids (0.12–2.18), K (0.39–0.78), P (0.14–0.87), and S (0.07–0.85). The least release was for Ba (0.04–0.17), Fe (0.03–0.41) and B (− 0.006 to 2.33). Dill showed the most important effect on the Na concentration of honey enriched (at 5.00%) with > 90 times higher content (328 ± 4 mg/kg) compared to control honey (3.46 ± 0.07 mg/kg). Sr content was more than 50 times higher in honey enriched with marjoram (1383 ± 10 µg/kg), and honey enriched with dill showed more than 30 times higher Fe content (4112 ± 14 µg/kg). Enrichment with dill had the greatest effect on Ca, Cu, K, Mg, Na and Fe content of control honey, and garlic had the most important effect on the B, P, S, Zn, TP and TF content. Enrichment with these herbs and spices resulted in increases in element, total phenolic and flavonoid content of acacia honey.
Forecasting emotions: exploring the relationship between self-control, affective forecasting, and self-regulatory behavior
Authors: Strömbäck Camilla 
Published: June 2024

AbstractEmpirical evidence has shown that people with better self-control to a greater extent have the self-regulatory ability to act in line with their long-term goals. In this pre-registered study, the relationship between self-control and self-regulatory behavior was investigated both directly and indirectly, i.e., through affective forecasting ability. This is of great interest as it is necessary to be able to forecast one's emotional response to future events in order to make choices that maximize one's happiness. However, in a laboratory experiment with undergraduate students, I found no evidence of self-control being associated with affective forecasting ability, or that people with better self-control more often acted in a way that maximized their expected happiness.
Zufallsbefunde: submuköser Tumor bei der Gastroskopie
Authors: Tribl Barbara 
Published: June 2024

ZusammenfassungSubmuköse Tumoren sind meist asymptomatisch und sind in der Regel ein Zufallsbefund bei der Gastroskopie. Submuköse Tumoren können aber auch symptomatisch werden im Rahmen einer gastrointestinalen Blutung bzw. durch eine Eisenmangelanämie oder aber durch Schmerzen infolge einer Obstruktion – bevorzugt an anatomischen Engstellen wie an der Cardia ventriculi oder dem Pylorus. Nur ein Teil der submukösen Tumoren benötigt eine Resektion bzw. eine Surveillance. Die Endosonographie mit der Option der Gewebegewinnung ist ein wesentlicher Bestandteil der Diagnostik und soll häufiger zur Diagnosesicherung eingesetzt werden. Es besteht die Empfehlung, nur Läsionen zu resezieren, die ein malignes Risiko haben oder Symptome verursachen.
Research advances on standards and processing methods of texture-modified foods for dysphagia: a review
Authors: Liu Tong , Liu Caiyun , Wang Xin 
Published: June 2024

AbstractAs a remarkably common clinical symptom of many diseases, dysphagia has become a major public health issue. Texture-modified foods is a widespread therapeutic strategy for dysphagia, but the design of texture-modified foods is a challenging task. Considering that the implementation of standardized terms and definitions are helpful for the texture modification of food, literature reviews has been conducted in this paper and relevant classification standards in different countries were summarized. And the techniques and means for food texture modification, such as traditional dietary softening approaches, use of biopolymers, as well as emerging structural technologies were also discussed. In addition, potential research directions have been suggested for the design of texture-modified foods.
Thermal performance of a novel Trombe wall enhanced by a solar energy focusing approach
Authors: Dong Xianzhang , Xiao Huigang , Ma Minglei 
Published: June 2024

AbstractThe Trombe wall is a passive solar building exterior wall system proposed by Professor Felix Trombe in France, which can collect solar energy to heat buildings without additional energy consumption, making it a focal point of research in building energy conservation. However, its effectiveness is constrained by the low density of solar radiation in winter and the potential for overheating in summer. This study introduces a novel Trombe wall designed to address these issues through a focused strategy, enabling automatic transition between heating during winter and shading during summer. The thermal performance parameters of the novel Trombe walls in both winter and summer seasons are examined, and their energy consumption is assessed using experimental research methodologies. Findings indicate that the novel Trombe wall facilitates greater energy savings in both winter and summer. When compared with traditional Trombe walls, the novel Trombe wall achieves a significant reduction in energy consumption, with up to 55 W/m2 in heating load during winter and 47 W/m2 in cooling load during summer. The introduction of this new system holds substantial potential for the realization of zero-energy buildings.
Deep reinforcement learning for inverting earthquake focal mechanism and its potential application to marine earthquakes
Authors: Kuang Wenhuan , Zou Zhihui , Xing Junhui , Wei Wei 
Published: June 2024

AbstractEarthquake data are one of the key means by which to explore our planet. At a large scale, the layered structure of the Earth is revealed by the seismic waves of natural earthquakes that go deep into its inner core. At a local scale, seismology for exploration has successfully been employed to discover massive fossil energies. As the volume of recorded seismic data becomes greater, intelligent methods for processing such a volume of data are eagerly anticipated. In particular, earthquake focal mechanisms are important for assessing the severity of tsunamis, characterizing seismogenic faults, and investigating the stress perturbations that follow a major earthquake. Here, we report a novel deep reinforcement learning method for inverting the earthquake focal mechanism. Unlike more typical deep learning applications, which require a large training dataset, a deep reinforcement learning system learns by itself. We demonstrate the validity and efficacy of the proposed deep reinforcement learning method by applying it to the Mw 7.1 mainshock of the Ridgecrest earthquakes in southern California. In the foreseeable future, deep learning technologies may greatly contribute to our understanding of the oceanographic process. The proposed method may help us understand the mechanism of marine earthquakes.
Mitigating Toxic Metal Exposure Through Leafy Greens: A Comprehensive Review Contrasting Cadmium and Lead in Spinach
Authors: Seyfferth Angelia L. , Limmer Matt A. , Runkle Benjamin R. K. , Chaney Rufus L. 
Published: June 2024

AbstractMetals and metalloids (hereafter, metal(loid)s) in plant‐based foods are a source of exposure to humans, but not all metal(loid)‐food interactions are the same. Differences exist between metal(loid)s in terms of their behavior in soils and in how they are taken up by plants and stored in the edible plant tissue/food. Thus, there cannot be one consistent solution to reducing toxic metal(loid)s exposure to humans from foods. In addition, how metal(loid)s are absorbed, distributed, metabolized, and excreted by the human body differs based on both the metal(loid), other elements and nutrients in the food, and the nutritional status of the human. Initiatives like the United States Food and Drug Administration's Closer to Zero initiative to reduce the exposure of young children to the toxic elements cadmium, lead, arsenic, and mercury from foods warrant careful consideration of each metal(loid) and plant interaction. This review explores such plant‐metal(loid) interactions using the example of spinach and the metals cadmium and lead. This review highlights differences in the magnitude of exposure, bioavailability, and the practicality of mitigation strategies while outlining research gaps and future needs. A focus on feasibility and producer needs, informed via stakeholder interviews, emphasizes the need for better analytical testing facilities and grower and consumer education. More research should focus on minimization of chloride inputs for leafy greens to lessen plant‐availability of Cd and the role of oxalate in reducing Cd bioavailability from spinach. These findings are applicable to other leafy greens (e.g., kale, lettuce), but not for other plants or metal(loid)s.
Whistler Waves in the Quasi‐Parallel and Quasi‐Perpendicular Magnetosheath
Authors: Svenningsson I. , Yordanova E. , Khotyaintsev Yu. V. , André M. , Cozzani G. , Steinvall K. 
Published: June 2024

AbstractIn the Earth's magnetosheath (MSH), several processes contribute to energy dissipation and plasma heating, one of which is wave‐particle interactions between whistler waves and electrons. However, the overall impact of whistlers on electron dynamics in the MSH remains to be quantified. We analyze 18 hr of burst‐mode measurements from the Magnetospheric Multiscale (MMS) mission, including data from the unbiased magnetosheath campaign during February‐March 2023. We present a statistical study of 34,409 whistler waves found using automatic detection. We compare wave occurrence in the different MSH geometries and find three times higher occurrence in the quasi‐perpendicular MSH compared to the quasi‐parallel case. We also study the wave properties and find that the waves propagate quasi‐parallel to the background magnetic field, have a median frequency of 0.2 times the electron cyclotron frequency, median amplitude of 0.03–0.06 nT (30–60 pT), and median duration of a few tens of wave periods. The whistler waves are preferentially observed in local magnetic dips and density peaks and are not associated with an increased temperature anisotropy. Also, almost no whistlers are observed in regions with parallel electron plasma beta lower than 0.1. Importantly, when estimating pitch‐angle diffusion times we find that the whistler waves cause significant pitch‐angle scattering of electrons in the MSH.
C-terminally phosphorylated p27 activates self-renewal driver genes to program cancer stem cell expansion, mammary hyperplasia and cancer
Authors: Razavipour Seyedeh Fatemeh , Yoon Hyunho , Jang Kibeom , Kim Minsoon , Nawara Hend M. , Bagheri Amir , Huang Wei-Chi , Shin Miyoung , Zhao Dekuang , Zhou Zhiqun , Van Boven Derek , Briegel Karoline , Morey Lluis , Ince Tan A. , Johnson Michael , Slingerland Joyce M. 
Published: June 2024

AbstractIn many cancers, a stem-like cell subpopulation mediates tumor initiation, dissemination and drug resistance. Here, we report that cancer stem cell (CSC) abundance is transcriptionally regulated by C-terminally phosphorylated p27 (p27pT157pT198). Mechanistically, this arises through p27 co-recruitment with STAT3/CBP to gene regulators of CSC self-renewal including MYC, the Notch ligand JAG1, and ANGPTL4. p27pTpT/STAT3 also recruits a SIN3A/HDAC1 complex to co-repress the Pyk2 inhibitor, PTPN12. Pyk2, in turn, activates STAT3, creating a feed-forward loop increasing stem-like properties in vitro and tumor-initiating stem cells in vivo. The p27-activated gene profile is over-represented in STAT3 activated human breast cancers. Furthermore, mammary transgenic expression of phosphomimetic, cyclin-CDK-binding defective p27 (p27CK-DD) increases mammary duct branching morphogenesis, yielding hyperplasia and microinvasive cancers that can metastasize to liver, further supporting a role for p27pTpT in CSC expansion. Thus, p27pTpT interacts with STAT3, driving transcriptional programs governing stem cell expansion or maintenance in normal and cancer tissues.
An electrochemically responsive B–O dynamic bond to switch photoluminescence of boron-nitrogen-doped polyaromatics
Authors: Yang Baige , Zhang Yu-Mo , Wang Chunyu , Gu Chang , Li Chenglong , Yin Hang , Yan Yan , Yang Guojian , Zhang Sean Xiao-An 
Published: June 2024

AbstractBoron-doped polycyclic aromatic hydrocarbons exhibit excellent optical properties, and regulating their photophysical processes is a powerful strategy to understand the luminescence mechanism and develop new materials and applications. Herein, an electrochemically responsive B–O dynamic coordination bond is proposed, and used to regulate the photophysical processes of boron-nitrogen-doped polyaromatic hydrocarbons. The formation of the B–O coordination bond under a suitable voltage is confirmed by experiments and theoretical calculations, and B–O coordination bond can be broken back to the initial state under opposite voltage. The whole process is accompanied by reversible changes in photophysical properties. Further, electrofluorochromic devices are successfully prepared based on the above electrochemically responsive coordination bond. The success and harvest of this exploration are beneficial to understand the luminescence mechanism of boron-nitrogen-doped polyaromatic hydrocarbons, and provide ideas for design of dynamic covalent bonds and broaden material types and applications.
Hyperbaric oxygen enhances tumor penetration and accumulation of engineered bacteria for synergistic photothermal immunotherapy
Authors: Xu Ke-Fei , Wu Shun-Yu , Wang Zihao , Guo Yuxin , Zhu Ya-Xuan , Li Chengcheng , Shan Bai-Hui , Zhang Xinping , Liu Xiaoyang , Wu Fu-Gen 
Published: June 2024

AbstractBacteria-mediated cancer therapeutic strategies have attracted increasing interest due to their intrinsic tumor tropism. However, bacteria-based drugs face several challenges including the large size of bacteria and dense extracellular matrix, limiting their intratumoral delivery efficiency. In this study, we find that hyperbaric oxygen (HBO), a noninvasive therapeutic method, can effectively deplete the dense extracellular matrix and thus enhance the bacterial accumulation within tumors. Inspired by this finding, we modify Escherichia coli Nissle 1917 (EcN) with cypate molecules to yield EcN-cypate for photothermal therapy, which can subsequently induce immunogenic cell death (ICD). Importantly, HBO treatment significantly increases the intratumoral accumulation of EcN-cypate and facilitates the intratumoral infiltration of immune cells to realize desirable tumor eradication through photothermal therapy and ICD-induced immunotherapy. Our work provides a facile and noninvasive strategy to enhance the intratumoral delivery efficiency of natural/engineered bacteria, and may promote the clinical translation of bacteria-mediated synergistic cancer therapy.
Accelerometer-derived physical activity and mortality in individuals with type 2 diabetes
Authors: Cao Zhi , Min Jiahao , Chen Han , Hou Yabing , Yang Hongxi , Si Keyi , Xu Chenjie 
Published: June 2024

AbstractPhysical activity (PA) has been shown to reduce diabetes mortality, but largely based on imprecise self-reported data, which may hinder the development of related recommendations. Here, we perform a prospective cohort study of 4003 individuals with type 2 diabetes (T2D) from the UK Biobank with a median follow-up of 6.9 years. Duration and intensity of PA are measured by wrist-worn accelerometers over a 7-day period. We observe L-shaped associations of longer duration of PA, regardless of PA intensity, with risks of all-cause and cancer mortality, as well as a negatively linear association with cardiovascular disease mortality. 18.8%, 28.0%, and 31.1% of deaths are attributable to the lowest level of light-intensity PA, moderate-intensity PA, and vigorous-intensity PA, respectively. Collectively, our findings provide insights for clinical guidelines that should highlight the potential value of adherence to greater intensity and duration of PA for patients with T2D.
Low potassium activation of proximal mTOR/AKT signaling is mediated by Kir4.2
Authors: Zhang Yahua , Bock Fabian , Ferdaus Mohammed , Arroyo Juan Pablo , L Rose Kristie , Patel Purvi , Denton Jerod S. , Delpire Eric , Weinstein Alan M. , Zhang Ming-Zhi , Harris Raymond C. , Terker Andrew S. 
Published: June 2024

AbstractThe renal epithelium is sensitive to changes in blood potassium (K+). We identify the basolateral K+ channel, Kir4.2, as a mediator of the proximal tubule response to K+ deficiency. Mice lacking Kir4.2 have a compensated baseline phenotype whereby they increase their distal transport burden to maintain homeostasis. Upon dietary K+ depletion, knockout animals decompensate as evidenced by increased urinary K+ excretion and development of a proximal renal tubular acidosis. Potassium wasting is not proximal in origin but is caused by higher ENaC activity and depends upon increased distal sodium delivery. Three-dimensional imaging reveals Kir4.2 knockouts fail to undergo proximal tubule expansion, while the distal convoluted tubule response is exaggerated. AKT signaling mediates the dietary K+ response, which is blunted in Kir4.2 knockouts. Lastly, we demonstrate in isolated tubules that AKT phosphorylation in response to low K+ depends upon mTORC2 activation by secondary changes in Cl- transport. Data support a proximal role for cell Cl- which, as it does along the distal nephron, responds to K+ changes to activate kinase signaling.
Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates
Authors: Balzano Tiziano , del Rey Natalia López-González , Esteban-García Noelia , Reinares-Sebastián Alejandro , Pineda-Pardo José A. , Trigo-Damas Inés , Obeso José A. , Blesa Javier 
Published: June 2024

AbstractDopaminergic neurons in the ventral tier of the substantia nigra pars compacta (SNc) degenerate prominently in Parkinson’s disease (PD), while those in the dorsal tier and ventral tegmental area are relatively spared. The factors determining why these neurons are more vulnerable than others are still unrevealed. Neuroinflammation and immune cell infiltration have been demonstrated to be a key feature of neurodegeneration in PD. However, the link between selective dopaminergic neuron vulnerability, glial and immune cell response, and vascularization and their interactions has not been deciphered. We aimed to investigate the contribution of glial cell activation and immune cell infiltration in the selective vulnerability of ventral dopaminergic neurons within the midbrain in a non-human primate model of PD. Structural characteristics of the vasculature within specific regions of the midbrain were also evaluated. Parkinsonian monkeys exhibited significant microglial and astroglial activation in the whole midbrain, but no major sub-regional differences were observed. Remarkably, the ventral substantia nigra was found to be typically more vascularized compared to other regions. This feature might play some role in making this region more susceptible to immune cell infiltration under pathological conditions, as greater infiltration of both T- and B- lymphocytes was observed in parkinsonian monkeys. Higher vascular density within the ventral region of the SNc may be a relevant factor for differential vulnerability of dopaminergic neurons in the midbrain. The increased infiltration of T- and B- cells in this region, alongside other molecules or toxins, may also contribute to the susceptibility of dopaminergic neurons in PD.
Chromosomal-scale genome assembly of the Mediterranean mussel Mytilus galloprovincialis
Authors: Han Guo-dong , Ma Dan-dan , Du Li-na , Zhao Zhen-jun 
Published: June 2024

AbstractThe Mediterranean mussel, Mytilus galloprovincialis, is a significant marine bivalve species that has ecological and economic importance. This species is robustly resilient and highly invasive. Despite the scientific and commercial interest in studying its biology and aquaculture, there remains a need for a high-quality, chromosome-scale reference genome. In this study, we have assembled a high-quality chromosome-scale reference genome for M. galloprovincialis. The total length of our reference genome is 1.41 Gb, with a scaffold N50 sequence length of 96.9 Mb. BUSCO analysis revealed a 97.5% completeness based on complete BUSCOs. Compared to the four other available M. galloprovincialis assemblies, the assembly described here is dramatically improved in both contiguity and completeness. This new reference genome will greatly contribute to a deeper understanding of the resilience and invasiveness of M. galloprovincialis.