bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bridging the Gap between Class and Space: U.S. Worker Solidarity with Guatemala
Authors: Johns Rebecca A. 
Published: August 2010

Abstract: In recent decades organized labor in the United States has responded to restructuring of the global economy by increasing its commitment to international solidarity, providing moral and material support for the organizing efforts of workers abroad. The international labor solidarity strategy appears to be designed to lessen the competition among places over investment, plant location, and jobs by uniting workers in different countries on the basis of their shared class interests. Yet international solidarity programs may serve to benefit one geographically distinct group of workers over another without challenging capitalism's allocative mechanisms. I develop criteria for differentiating between the latter kind of solidarity campaigns, which I call accommodationist, and transformatory solidarity, which attempts to prevent capital from using space to weaken workers' organizations, thereby altering the labor‐capital relationship in fundamental ways. I then examine the work of an organization of union members and workers in the United States committed to forming relationships of solidarity with workers in Guatemala. I look at the history, philosophy, and activities of the U.S./Guatemala Labor Education Project (US/GLEP), which provides an informative case study of the opportunities and dangers of international solidarity. The limitations of international solidarity campaigns are identified, and I suggest ways to overcome these barriers.spatial relations,
Principles and Practices of Knowledge Creation: On the Organization of “Buzz” and “Pipelines” in Life Science Communities
Authors: Moodysson Jerker 
Published: August 2010

abstractThis article links up with the debate in economic geography on “local buzz” and “global pipelines” as two distinct forms of interactive knowledge creation among firms and related actors and argues for a rethinking of the way social scientists should approach interactive knowledge creation. It highlights the importance of combining the insights from studies of clusters and innovation systems with an activity‐oriented approach in which more attention is paid to the specific characteristics of the innovation processes and the conditions underpinning their organization. To illustrate the applicability and added value of such an alternative approach, the notion of embeddedness is linked with some basic ideas adopted from the literature on knowledge communities. The framework is then applied to a study of innovation activities conducted by firms and academic research groups working with biotechnology‐related applications in the Swedish part of the Medicon Valley life science region. The findings reveal that local buzz is largely absent in these types of activities. Most interactive knowledge creation, which appears to be spontaneous and unregulated, is, on closer examination, found safely embedded in globally configured professional knowledge communities and attainable only by those who qualify.
Participation in Export Markets and Productivity of Plants in Los Angeles, 1987–1997
Authors: Breau Sébastien , Rigby David 
Published: August 2010

AbstractThis article investigates the relationship between the productivity of plants and participation in export markets in the greater Los Angeles area using unpublished plant‐level data from the U.S. Census Bureau's Longitudinal Research Database. Two key questions are examined: (1) do plants that export learn in foreign markets and become more efficient, or (2) do more efficient plants self‐select into export markets? The results support previous claims that more productive plants tend to self‐select into export markets. Little support is found for the learning‐by‐exporting argument. The policy implications of these findings are discussed.
Economic Geographies of Financialization
Authors: Pike Andy , Pollard Jane 
Published: August 2010

abstractThis article argues that financialization—shorthand for the growing influence of capital markets, their intermediaries, and processes in contemporary economic and political life—generates an analytical opportunity and political economic imperative to move finance into the heart of economic geographic analysis. Drawing upon long‐standing concerns about the relatively marginal location of finance in economic geography, we emphasize the integral role of finance in connecting the entangled geographies of the economic to the social, the cultural, and the political. In the wake of various “turns” in the discipline, we develop this integrationist approach to finance in ways that retain political economies of states, markets, and social power in our interpretations of geographically uneven development. In this article, we discuss the plural nature of emergent work on financialization and develop three analytical themes to shape our discussion of financialization. Next, we elaborate our analytical approach by warning against functional, political, and spatial disconnections traced in the literature on the geographies of money. We then explore how financialization is broadening and deepening the array of agents, relations, and sites that require consideration in economic geography and is generating tensions between territorial and relational spatialities of geographic differentiation. Finally, we address the relative dearth of empirical work by examining the financialization of brands that have shaped the evolution of the brewing business and the development of new derivative instruments to hedge against weather risks. We conclude by arguing that our analysis of financialization demonstrates how finance occupies an integral position within economic geographies and reveals some of the sociospatial relations, constructions, and reach of existing and new actors, relations, and sites in shaping the uneven development of financialized contemporary capitalism.
A review of the characteristics and treatment of methicillin‐resistantStaphylococcus aureus(MRSA) in the horse and a case series of MRSA infection in four horses
Authors: Maddox T. W. , Scantlebury C. E. , Clegg P. D. , Dawson S. , Pinchbeck G. L. , Williams N. J. 
Published: August 2010

SummaryMethicillin‐resistantStaphylococcus aureus(MRSA) is an emerging cause of serious bacterial infection in the horse, with an increasing number of cases reported over the last decade. MRSA, along with other commensal staphylococcal species, can reside on the mucosa of several sites in the horse, particularly the nose. Nasal carriage of MRSA appears rare amongst horses in the community, although a higher prevalence has been found in hospitalised horses. MRSA infections can involve a variety of body sites, but most commonly encountered are soft tissue infections of either traumatic or surgical wounds. MRSA strain types isolated from horses are typically multidrug‐resistant and usually differ from those recovered from humans and other small animal species. Treatment of infection can be prolonged and is dependent on timely, accurate diagnosis and on appropriate therapy; often guided by antimicrobial susceptibility testing. The purpose of this review is to provide clinically relevant information for the equine practitioner and, for illustration, the diagnosis, treatment and outcome of 4 clinical cases of MRSA infection in horses is discussed.
Ultrasonographic examination of the caudal structures of the distal antebrachium in the horse
Authors: Jorgensen J. S. , Stewart A. A. , Stewart M. C. , Genovese R. L. 
Published: August 2010

SummaryEvaluation of the caudal distal antebrachium using ultrasound is a very useful diagnostic procedure for identification of soft tissue abnormalities in flexor structures of the equine limb. In this article we describe how ultrasonographic imaging may be used to complement radiography of the carpus in evaluating horses that present with peri‐carpal swelling and/or lameness localised to the carpal region.Ultrasonographic examination assists with the identification or exclusion of significant injuries to muscular, tendonous and ligamentous structures within the distal antebrachium and enables practitioners to proceed with appropriate therapeutic and rehabilitation plans for the immediate benefit for their patients while also recognising pathology that could progress to cause long‐term, chronic lameness issues without aggressive and effective intervention.
Minimally invasive desmotomy of the accessory ligament of the deep digital flexor tendon in horses
Authors: Tnibar A. , Christophersen M. T. , Lindegaard C. 
Published: August 2010

SummaryThis retrospective study describes ultrasound guided desmotomy of the accessory ligament of the deep digital flexor tendon in 35 cases, and a modification of this procedure using an adapted surgical instrument. The procedure was successful in 97% of cases. Wound healing was excellent in all except 4 cases. Corrective shoeing prior to surgery contributes to success. The procedure can be performed on the standing horse and offers the advantages of minimally invasive surgery which include: reduced incision length, reduced morbidity and improved cosmetic outcome. The adapted surgical instrument can be an alternative to isolate the ligament under ultrasound guidance.
Coexistence of Different Genotypes in the Same Bat and Serological Characterization of
Rousettus
Bat Coronavirus HKU9 Belonging to a Novel
Betacoronavirus
Subgroup
Authors: Lau Susanna K. P. , Poon Rosana W. S. , Wong Beatrice H. L. , Wang Ming , Huang Yi , Xu Huifang , Guo Rongtong , Li Kenneth S. M. , Gao Kai , Chan Kwok-Hung , Zheng Bo-Jian , Woo Patrick C. Y. , Yuen Kwok-Yung 
Published: August 2010

ABSTRACT

Rousettus
bat coronavirus HKU9 (Ro-BatCoV HKU9), a recently identified coronavirus of novel
Betacoronavirus
subgroup D, from Leschenault's rousette, was previously found to display marked sequence polymorphism among genomes of four strains. Among 10 bats with complete RNA-dependent RNA polymerase (RdRp), spike (S), and nucleocapsid (N) genes sequenced, three and two sequence clades for all three genes were codetected in two and five bats, respectively, suggesting the coexistence of two or three distinct genotypes of Ro-BatCoV HKU9 in the same bat. Complete genome sequencing of the distinct genotypes from two bats, using degenerate/genome-specific primers with overlapping sequences confirmed by specific PCR, supported the coexistence of at least two distinct genomes in each bat. Recombination analysis using eight Ro-BatCoV HKU9 genomes showed possible recombination events between strains from different bat individuals, which may have allowed for the generation of different genotypes. Western blot assays using recombinant N proteins of Ro-BatCoV HKU9,
Betacoronavirus
subgroup A (HCoV-HKU1), subgroup B (SARSr-Rh-BatCoV), and subgroup C (Ty-BatCoV HKU4 and Pi-BatCoV HKU5) coronaviruses were subgroup specific, supporting their classification as separate subgroups under
Betacoronavirus
. Antibodies were detected in 75 (43%) of 175 and 224 (64%) of 350 tested serum samples from Leschenault's rousette bats by Ro-BatCoV HKU9 N-protein-based Western blot and enzyme immunoassays, respectively. This is the first report describing coinfection of different coronavirus genotypes in bats and coronavirus genotypes of diverse nucleotide variation in the same host. Such unique phenomena, and the unusual instability of ORF7a, are likely due to recombination which may have been facilitated by the dense roosting behavior and long foraging range of Leschenault's rousette.
Age-dependent prognostic effects of EGFR/p53 alterations in glioblastoma: study on a prospective cohort of 140 uniformly treated adult patients
Authors: Srividya M R , Thota Balaram , Arivazhagan A , Thennarasu K , Balasubramaniam A , Chandramouli B A , Hegde A S , Santosh V 
Published: August 2010

AimsTo assess the prognostic influence of EGFR amplification/overexpression, p53 immunoreactivity and their age-dependent prognostic effects in a large prospective cohort of uniformly treated adult patients with newly diagnosed glioblastoma.MethodsTumours from a uniformly treated prospective cohort of adult patients with newly diagnosed glioblastoma (n=140) were examined for EGFR amplification by fluorescence in situ hybridisation and EGFR/p53 expression by immunohistochemistry. Statistical methods were employed to assess the degree of association between EGFR amplification/overexpression and p53 immunopositivity. Survival analyses were performed by employing Cox proportional hazard models to assess the independent prognostic value of EGFR/p53 alterations and test the propensity for risk with age by assessing their interaction with patient age.ResultsA strong positive correlation between EGFR amplification and EGFR overexpression (ρ=0.5157; p<0.0001; CI 0.3783 to 0.6309) and a negative association of EGFR amplification (ρ=−0.3417; p<0.0001; CI −0.4842 to −0.1816) and EGFR overexpression (ρ=−0.3095; p<0.001; CI −0.4561 to −0.1465) with p53 immunopositivity was observed. Only patient age (HR: 1.029; p=0.004; CI 1.009 to 1.049) was associated with shorter survival by univariate Cox regression analysis. Multivariable Cox proportional hazards models revealed a statistically significant interaction between EGFR overexpression and age to be associated with shorter survival (HR: 1.001; p<0.0001; CI 1.000 to 1.002), thus predicting a higher hazard with increasing age. No age interaction of EGFR amplification status (HR: 1.001; p=0.642; CI 0.995 to 1.008) and p53 immunopositivity (HR: 1.000; p=0.841; CI 0.999 to 1.001) was noted in this cohort.ConclusionsThe prognostic value of EGFR overexpression is age-dependent, and there is a propensity for a higher hazard with increasing patient age. Identifying such groups of patients with more aggressive disease becomes mandatory, since they would benefit from intense therapeutic protocols targeting EGFR.
Finite differencing of logical formulas for static analysis
Authors: Reps Thomas , Sagiv Mooly , Loginov Alexey 
Published: August 2010

This article concerns mechanisms for maintaining the value of an instrumentation relation (also known as a
derived relation
or
view
), defined via a logical formula over core relations, in response to changes in the values of the core relations. It presents an algorithm for transforming the instrumentation relation's defining formula into a
relation-maintenance formula
that captures what the instrumentation relation's new value should be. The algorithm runs in time linear in the size of the defining formula.

The technique applies to program analysis problems in which the semantics of statements is expressed using logical formulas that describe changes to core relation values. It provides a way to obtain values of the instrumentation relations that reflect the changes in core relation values produced by executing a given statement.
We present experimental evidence that our technique is an effective one: for a variety of benchmarks, the relation-maintenance formulas produced automatically using our approach yield the same precision as the best available hand-crafted ones.
Convergence of Three-Step Iterations Scheme for Nonself Asymptotically Nonexpansive Mappings
Authors: Temir Seyit 
Published: August 2010

AbstractWeak and strong convergence theorems of three-step iterations are established for nonself asymptotically nonexpansive mappings in uniformly convex Banach space. The results obtained in this paper extend and improve the recent ones announced by Suantai (2005), Khan and Hussain (2008), Nilsrakoo and Saejung (2006), and many others.
Suppression of Casein Kinase 1α in Melanoma Cells Induces a Switch in β-Catenin Signaling to Promote Metastasis
Authors: Sinnberg Tobias , Menzel Moritz , Kaesler Susanne , Biedermann Tilo , Sauer Birgit , Nahnsen Sven , Schwarz Michael , Garbe Claus , Schittek Birgit 
Published: August 2010

Abstract
Casein kinase 1 α (CK1α) is a multifunctional Ser/Thr kinase that phosphorylates several substrates. Among those is β-catenin, an important player in cell adhesion and Wnt signaling. Phosphorylation of β-catenin by CK1α at Ser45 is the priming reaction for the proteasomal degradation of β-catenin. Interestingly, aside from this role in β-catenin degradation, very little is known about the expression and functional role of CK1α in tumor cells. Here, we show that CK1α expression in different tumor types is either strongly suppressed or completely lost during tumor progression and that CK1α is a key factor determining β-catenin stability and transcriptional activity in tumor cells. CK1α reexpression in metastatic melanoma cells reduces growth in vitro and metastasis formation in vivo, and induces cell cycle arrest and apoptosis, whereas suppression of CK1α in primary melanoma cells induces invasive tumor growth. Inactivation of CK1α promotes tumor progression by regulating a switch in β-catenin–mediated signaling. These results show that melanoma cells developed an efficient new mechanism to activate the β-catenin signaling pathway and define CK1α as a novel tumor suppressor. Cancer Res; 70(17); 6999–7009. ©2010 AACR.
Reciprocal Activation of Prostate Cancer Cells and Cancer-Associated Fibroblasts Stimulates Epithelial-Mesenchymal Transition and Cancer Stemness
Authors: Giannoni Elisa , Bianchini Francesca , Masieri Lorenzo , Serni Sergio , Torre Eugenio , Calorini Lido , Chiarugi Paola 
Published: August 2010

Abstract
Although cancer-associated fibroblasts (CAF) are key determinants in the malignant progression of cancer, their functional contribution to this process is still unclear. Analysis of the mutual interplay between prostate carcinoma cells and CAFs revealed a mandatory role of carcinoma-derived interleukin-6 in fibroblast activation. In turn, activated fibroblasts through secretion of metalloproteinases elicit in cancer cells a clear epithelial-mesenchymal transition (EMT), as well as enhancement of tumor growth and development of spontaneous metastases. CAF-induced EMT leads prostate carcinoma cells to enhance expression of stem cell markers, as well as the ability to form prostaspheres and to self-renew. Hence, the paracrine interplay between CAFs and cancer cells leads to an EMT-driven gain of cancer stem cell properties associated with aggressiveness and metastatic spread. Cancer Res; 70(17); 6945–56. ©2010 AACR.
Matrix Metalloproteinase-9 Is Upregulated in Nucleophosmin-Anaplastic Lymphoma Kinase–Positive Anaplastic Lymphomas and Activated at the Cell Surface by the Chaperone Heat Shock Protein 90 to Promote Cell Invasion
Authors: Lagarrigue Frédéric , Dupuis-Coronas Sophie , Ramel Damien , Delsol Georges , Tronchère Hélène , Payrastre Bernard , Gaits-Iacovoni Frédérique 
Published: August 2010

Abstract
Many anaplastic large cell lymphomas (ALCL) express the chimeric oncogene NPM-ALK, which drives malignant transformation and invasion. In this study, we show that NPM-ALK expression increases matrix metalloproteinase-9 (MMP-9) expression. Accordingly, we found that 100% of a large panel of ALK(+) ALCL biopsies examined were also MMP-9(+), in contrast to only 36.3% of ALK(−) tumors. Mechanistic studies revealed that Rac1 drove MMP-9 secretion. The MMP inhibitor GM6001 and MMP-9 blocking antibodies abolished the invasiveness of NPM-ALK(+) cells. Interestingly, the hyaluronan receptor CD44 acted as a docking surface for MMP-9 and the chaperone heat shock protein 90 on the cell surface, where MMP-9 was cleaved and activated. Membrane-associated MMP-9 was localized to invadopodia, which display a strong gelatinase activity. Taken together, our observations strengthen the concept that chaperones have a major extracellular role in the regulation of protein activation status, and reveal new factors that are crucial for spreading and invasion of ALK(+) ALCL. They also point out new factors crucial for ALK(+) ALCL. Cancer Res; 70(17); 6978–87. ©2010 AACR.
Synthetic Progestins Differentially Promote or Prevent 7,12-Dimethylbenz(a)anthracene–Induced Mammary Tumors in Sprague-Dawley Rats
Authors: Benakanakere Indira , Besch-Williford Cynthia , Carroll Candace E. , Hyder Salman M. 
Published: August 2010

Abstract
Recent clinical trials show that combined oral dosing with estrogen and progestin increases the incidence of breast cancer in postmenopausal women. Similarly, in a rat model system of mammary carcinogenesis, the synthetic progestin medroxyprogesterone acetate (MPA) decreases latency and increases incidence of 7,12-dimethylbenz(a)anthracene (DMBA)–induced mammary tumors. The goal of this study was to compare the effects of four clinically relevant progestins, MPA, norgestrel (N-EL), norethindrone (N-ONE), and megestrol acetate (MGA), on DMBA-induced mammary carcinogenesis in the rat. The experimental protocol involved implantation of 60-day release progestin pellets four weeks after rats were treated with DMBA. In contrast to the effect of MPA, N-ONE, and N-EL, but not MGA, blocked DMBA-dependent carcinogenesis and a dose-dependent effect on tumor growth was shown for N-EL; MGA did not alter tumor growth. Histopathologic studies showed extensive hyperplastic lesions in mammary tissue of progestin-treated animals. Furthermore, following treatment with N-EL or N-ONE, immunohistochemical staining for vascular endothelial growth factor in hyperplastic mammary tissue was lower than in animals treated with DMBA plus MPA or DMBA alone. Expression of vascular endothelial growth factor receptor-1, estrogen receptor α, and progesterone receptor was also lower in hyperplastic mammary tissue in N-EL–, N-ONE–, and MGA-treated animals. Interestingly, N-EL stimulated progression of existing mammary tumors in DMBA/MPA-treated rats, suggesting stage-specific effects of N-EL in this model. Because N-EL and N-ONE prevent tumor growth in the early stages of DMBA-induced mammary carcinogenesis in rats, these progestins may have potential as chemopreventive agents in women with no history of breast disease or family history of breast cancer. Cancer Prev Res; 3(9); 1157–67. ©2010 AACR.