bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral anticoagulants versus vitamin K antagonists in the treatment of non-valvular atrial fibrillation in patients with stage 4-5 chronic kidney disease
Authors: Skorodumova E. G. , Rubanenko O. A. , Rubanenko A. O. , Enginoev S. T. , Kercheva M. A. , Zaslavskaya E. L. , Efremova E. V. , Gubareva E. Yu. , Lyapina I. N. , Velieva R. M. , Skorodumova E. A. , Siverina A. V. 
Published: April 2024

Aim. To compare the effectiveness and safety of direct oral anticoagulants (DOACs) with a vitamin K antagonist (VKA) in patients with atrial fibrillation (AF) and stage 4 and 5 chronic kidney disease (CKD).Material and methods. We searched in the PubMed, Google Scholar, and Web of Science databases from 1990 to 2022 for studies that compared DOACs with VKAs in patients with AF and stage 4 and 5 CKD. The patient, intervention, comparison, outcome (PICO) search strategy was used. Data were extracted by independent researchers and meta-analyzed.Results. A total of 6 studies were included in this meta-analysis. In terms of effectiveness, DOACs were comparable to VKAs. In terms of safety, DOACs and VKAs also had no statistical differences in hemorrhagic stroke, minor/gastrointestinal bleeding, overall mortality, but there was statistical significance in major bleeding. Conclusion. In terms of efficacy and safety, in general, DOACs were comparable to VKAs, but there were a number of following differences: the administration of DOACs to patients with stage 4 and 5 CKD, as well as those on hemodialysis, was accompanied by a significant reduction in the number of major bleedings, compared with warfarin therapy.
Availability of basic first aid training for cardiac arrest for people with disabilities
Authors: Birkun A. A. , Kosova Ye. A. , Redkokosh K. I. , Gapon A. S. 
Published: April 2024

Aim. Basic first aid digital training for cardiac arrest opens up opportunities for mass dissemination of knowledge, popularization and motivation of the population to provide assistance, and can also replace the theoretical part of classroom training, reducing the cost of training. However, due to poor design, such training may not be available to people with disabilities (PWD), who constitute a large population of more than one billion potential participants in first aid. The aim was to study the digital accessibility (web accessibility) of massive open online courses in cardiopulmonary resuscitation (CPR) for PWD.Material and methods. A search was carried out for free English-language online courses teaching the principles and rules of providing first aid in cardiac arrest. In addition, the digital content of online courses was assessed for compliance with the international Web Content Accessibility Guidelines (WCAG) 2.1.Results. All basic CPR online courses analyzed (n=28) were characterized by poor web accessibility. For each course, between 26,9% and 51,3% of the WCAG 2.1 guideline success criteria were not met. All courses have web accessibility errors related to text contrast and visual issues, lack of alternative text descriptions for non-text content, missing abbreviations, and web page layout issues that prevent the use of assistive technologies (such as text-to-speech software). Overall, none of the courses meet all of the criteria for the minimum acceptable level of compliance with WCAG 2.1 guidelines. The discovered problems of web accessibility can serve as serious, sometimes insurmountable barriers to the mastery of courses by students (including older people) with visual impairments, hearing loss, motor, cognitive and neurological disorders.Conclusion. All free mass online courses on basic CPR have deficiencies in the availability of digital content, which significantly complicate the learning of educational materials by PWD. The development of uniform guidelines for accessible educational content, along with the intensification of research and the implementation of organizational and methodological measures to ensure the availability of educational resources on first aid for various categories of the population, should help create equal opportunities for quality training. In addition, this should significantly expand the population coverage with training, and increase the frequency and effectiveness of first aid.
Medication adherence of cardiovascular patients after COVID-19: 6-month follow-up
Authors: Tyapaeva A. R. , Naumova E. A. , Semenova O. N. , Bulaeva Yu. V. , Tyapkina D. A. , Boroday A. A. 
Published: April 2024

Aim. To evaluate the relationship of various factors with adherence to therapy in cardiovascular patients after a coronavirus disease 2019 (COVID-19).Material and methods. The study included 284 patients (inpatients — 176, outpatients — 108) with cardiovascular diseases (hypertension, heart failure (HF), coronary artery disease, atrial fibrillation) after COVID-19. We collected data on cardiovascular history, made a questionnaire survey about COVID-19 course (symptoms, their severity, self-assessment of the disease severity). Paraclinical diagnostic investigations were carried out. In addition, 1, 3, 6 months after recovery, all respondents were invited for examination, laboratory tests, and survey using the Hospital Anxiety and Depression Scale (HADS). Cardiovascular therapy adherence was assessed at 1, 3 and 6 months after recovery and adherence to COVID-19 treatment 1 month after inclusion in the study by comparing the compliance of the drugs prescribed at discharge with its actual use.Results. In total, 212 respondents continued study participation after 1 month, while 64,2% were adherent to cardiovascular therapy and 56,6% — to COVID-19 therapy. Compliance at 3 and 6 months was 60,4% (n=212) and 52,8% (n=188), respectively. A moderate correlation was found between adherence to treatment and the persistence of apprehension 1 month after recovery (r=0,33, p<0,05), moderate or severe weakness during disease (r=0,31, p<0,05), COVID-19 severity (r=0,39, p<0,05). Inhospital respondents with lung tissue involvement >25% (n=64, 36,4%) were more adherent to standard cardiovascular therapy, prescribed in accordance with clinical guidelines (r=0,336, p<0,05). Adverse events in the form of a hypertensive crisis, arrhythmias, decompensated HF 1, 3, 6 months after recovery significantly increased the compliance with medical recommendations (p<0,05). Medication adherence regarding COVID-19 was associated with the disease severity, HF history, apprehension and anxiety, weakness, and decreased exercise tolerance (p<0,05).Conclusion. After 1 month, adherence to cardiovascular and COVID-19 therapy did not differ significantly (p>0,05). Compliance after 1, 3, 6 months was positively influenced by COVID-19 severity, the subjective feeling of weakness, apprehension and anxiety during disease and the persistence of a subjective feeling of anxiety after recovery. Adverse events (hypertensive crisis, arrhythmia, decompensated HF) during 1, 3 and 6 months after COVID-19 significantly (p<0,05) increased adherence to treatment.
Aortic valve hemodynamic characteristics after the Ozaki procedure according to echocardiography: a multicenter retrospective study
Authors: Rashidova T. K. , Enginoev S. T. , Chernov I. I. , Kolesnikov V. N. , Komarov R. N. , Belov V. A. , Gamzaev A. B. , Arutyunyan V. B. , Kadyraliev B. K. , Semagin A. P. , Kuznetsov D. V. , Zybin A. A. , Tlisov B. M. , Kalinina M. L. , Konovalov N. S. , Bolurova A. M. , Dzhambieva M. N. , Skorodumova E. G. 
Published: April 2024

Aim. To evaluate the aortic valve (AV) hemodynamic characteristics after the Ozaki procedure according to echocardiography.Material and methods. The retrospective multicenter study included 277 patients with AV defects who were operated on from January 2017 to June 2022 in five centers in Russia. After the Ozaki procedure, the following endpoints were assessed: immediate echocardiographic results (peak AV gradient, mean AV gradient, AV effective orifice area, aortic regurgitation grade), mid-term clinical (three-year survival rate, three-year freedom from reoperation, three-year freedom from grade ≤2 aortic regurgitation) and echocardiographic results (peak and mean AV gradient, AV effective orifice area, aortic regurgitation grade, AV calcification severity). The median follow-up period was 23 (13-32) months. The mean echocardiography follow-up period was 21±10 months.Results. During the treatment, a decrease in the peak AV gradient was observed from 74±30 mm Hg before surgery up to 12 (8-16) mm Hg one week after surgery, which remained in the mid-term period — 12 (9-15) mm Hg. There was also a decrease in the mean gradient from 40 (27-53) mm Hg before surgery up to 6 (4-8) mm Hg one week after surgery. By the mid-term period, the mean gradient was 6 (4-8) mm Hg. The AV effective orifice area increased from 1 (1-1) cm2 to 2 (2-2) cm2 in the mid-term follow-up period. Three-year survival rate was 90,2%, freedom from reoperation was 95%, freedom from grade ³2 aortic regurgitation was 88%, and no patient had AV calcification.Conclusion. The Ozaki procedure in patients with AV defects has good immediate and mid-term hemodynamic parameters according to echocardiography. However, there remains a need for large randomized controlled trials comparing Ozaki procedure with biological AV replacement.
Analysis of factors influencing doctors' awareness of clinical guidelines for heart failure treatment
Authors: Perepech N. B. , Tregubov A. V. , Mikhailova I. E. 
Published: April 2024

Aim. To find out the relationship between the awareness level of clinical guidelines on heart failure (HF) with reduced ejection fraction and a number of professional characteristics (specialty, work experience, self-assessment of awareness level, attitude towards the use of guidelines, the main way of document study). To improve the efficiency and development of the postgraduate education system, the factors that influence doctors' awareness of guidelines should be determined.Material and methods. The study included the results of an anonymous survey of 207 doctors (155 cardiologists, 44 therapists, 8 doctors of other specialties). To assess the significance of differences, Student's t-test, c2-test and Fisher's exact test were used.Results. The mean number of correct answers to the questionnaire among cardiologists was significantly higher than among general practitioners (p<0,001). In the group of physicians with less than 5 years of work experience, there was a large variability in the mean number of correct answers — 6,2±4,0. Physicians with 6-10 years and 11-20 years of experience in their specialty were more likely to choose the correct answers than doctors with more than 20 years of experience. Professionals who considered themselves "fully informed" on clinical guidelines gave fewer correct answers than doctors who had less high self-rating (p<0,001). The proportion of correct answers in the subgroup of doctors who consider guidelines to be mandatory was greater than in the subgroups of doctors who hold a different opinion (p<0,05). The best results were shown by physicians who indicated direct text-oriented way as preferred for studying guidelines (p<0,001).Conclusion. The awareness level of clinical guidelines on the treatment of HF by cardiologists should be considered insufficient, and by therapists — extremely low. Doctors are not sufficiently informed about the need to comply with clinical guidelines. When planning training, the specialty and work experience of the doctor should be taken into account. Unjustifiably high self-rating of knowledge interferes with professional development. The best way of self-education should be considered direct study of the text of clinical guidelines.
O OMENTO MAIOR PODE SER DOADOR DE CÉLULAS-TRONCO AO MIOCÁRDIO ISQUÊMICO?
Authors: Kubrusly Fernando Bermudez , Ribas Filho Jurandir Marcondes , Nassif Paulo Afonso Nunes , Gewehr Douglas Mesadri , Piovesan João Lucchese , Santos Oscar Capistrano dos , Nascimento-Filho Geraldo Odilon do , Kubrusly Luiz Fernando 
Published: April 2024

Introdução: Recentes progressos feitos na bioengenharia de enxertos cardíacos oferecem nova modalidade terapêutica para a regeneração do tecido cardíaco pós-infarto do miocárdio. O CD34 é marcador que expressa todas as células precursoras hematopoiéticas e endoteliais, e funciona como fator de adesão celular. O anticorpo que correspondente a este marcador é utilizado na imunoistoquímica para avaliar a formação de novos vasos e a presença de células-tronco.
Objetivo: Avaliar a eficácia da omentopexia na neovascularização e células-tronco.
Métodos: Revisão colhendo informações publicadas em plataformas virtuais selecionadas (SciELO – Scientific Electronic Library Online, Google Scholar, Pubmed e Scopus). A busca iniciou-se por descritores relacionados ao tema, identificados por meio do DeCS/MESH nos seguintes descritores: “isquemia miocárdica; revascularização miocárdica; omentopexia; imunoistoquímica; CD34; células-tronco” e seus equivalentes em inglês: “stem cell; myocardial ischemia; myocardial revascularization; omentopexy; immunohistochemistry; CD34”. Foram lidos pelo título e resumo, com busca AND ou OR seguindo-se da leitura na íntegra daqueles com maior relação ao tema. Foram incluídos o total de 23 artigos.
Resultados: O omento maior tem propriedade clínica marcante em conter sítios de danos teciduais. Ele aumenta seu volume tecidual em resposta às partículas estranhas e inflamatórias envolvendo diversas células imunomoduladoras com células progenitoras, em um processo chamado “ativação do omento”.
Conclusão: A cárdio-omentopexia associada à abrasão mecânica e perfurações miocárdicas, mostra ser eficiente na indução de neovascularização. O omento maior promove células-tronco - confirmadas pelo CD34 -, demonstrando grande potencial como futura terapêutica para restaurar áreas de miocárdio isquêmico.
Psychological Research in the Multidisciplinary Discourse of Agency: Problems and Prospects
Authors: Mironenko Irina A. 
Published: April 2024

It is shown that the cause of the systemic difficulties experienced by the international mainstream of psychology in developing the problem of agency as a human ability to initiate a change in the environment is that the latter is a phenomenon that has not previously been the focus of attention for international psychology, and thus, for the analysis of which the old methodological optics of the Western-centric mainstream, which took shape in the second half of the 20th century and which is based on the theoretical model of the “universal” human, endowed with “universal” human qualities, is not applicable.
In the light of the theory of de-structuration (neo-structuration), focusing on qualitative and radical changes in the social world over the past decades, more promising approaches to understanding contemporary human personality are those grounding on considering personality as a culturally dependent and changeable entity, primarily the subjekt-activity approach which is developing in the Russian discourse and in the international science is not enough known. We consider the subjekt-activity approach not as one of those constituting the global mainstream, but as an alternative to the mainstream for theoretical and methodological grounds.
The prospects of developing the problem of agency from the standpoint of the subjekt-activity approach, both in terms of the theory and methodology of psychology, and in terms of practical applications, are substantiated. The relevance of practical applications of the subjekt-activity approach in the field of education is determined by the logic of social macro-processes. As a constructive approach to the development of the problem of agency in psychology, we propose to abandon the two dispositions that dominate in the mainstream: a) the search for the “center of agency” as a separate component and substructure of the psyche, which implements certain functions, skills, etc., - shifting to considering agency as a systemic and integral attribute of the individual, individually specific and developing during the lifetime (a “higher” psychic function); b) the search for the foundations of agency in the sphere of cognition and reflection - changing the focus of research to motivational and volitional sphere.
The long-term results of proximal interphalangeal joint arthroplasty of the hand
Authors: Fedotov P. V. , Kovalev D. V. , Rybakov S. N. 
Published: April 2024

Introduction Small joints replacement is a valid treatment for deforming osteoarthritis and traumatic injuries to the phalangeal joints of the hand to restore motor hand functions. Various types of implants differing in shape, biomechanics and material composition have been developed.The purpose of the study was to evaluate long-term results of the proximal interphalangeal joint arthroplasty of the hand using various implants and identify their advantages.Material and methods We retrospectively reviewed 78 cases of proximal interphalangeal joint replacement in 64 patients. Outcomes were assessed at 6 months and at follow-up stages with preoperative and postoperative measurements of the range of motion in the joint evaluating pain, radiographs and outcomes measures using the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire.Results The range of motion in the prosthetic joint increased significantly at different follow-up periods with all types of implants. The pain syndrome decreased. Radiographs revealed 10 cases of aseptic instability in the group of constrained prostheses. The DASH assessment showed high subjective satisfaction with the treatment.Discussion We could not find papers reporting PIP joint arthroplasty using SBI D.G.T. implant system. A retrospective study of RM Finger arthroplasty of the PIP joint indicated restored joint stability with AROM improvement and with low pain, although it had a high rate of complications. We recorded no complications with this implant model. Some authors would not recommend the RM Finger implant (Mathys) for PIP joint replacement. Arthroplasty of small joints of the hand with MOJE kermik-implantate showed satisfactory outcomes for 82 % of patients at a long term.Conclusion Arthroplasty of the PIP joint of the hand using various implant designs resulted in greater mobility of the upper limbs, a lower pain due to subjective improvement in the functionality at a long term. Although the procedures were effective with all implant designs the reliability of changes in the parameters was more evident with nonconstrained implants.
Validation and evaluation of the Russian version of the SEFAS questionnaire for assessing foot and ankle in surgically treated patients with forefoot disorders
Authors: Akulaev A. A. , Ivanov A. A. , Ionova T. I. , Nikitina T. P. , Tishchenkov K. A. , Povaliy A. A. 
Published: April 2024

Introduction The Self-reported Foot and Ankle Score (SEFAS) is one of the foot health assessment tools in Sweden. Validation procedures, reliability, validity, sensitivity, approval are essential for the Russian version of the questionnaire with a new language environment.The objective was to validate the Russian version of the SEFAS questionnaire and approve the tool in the Russian surgical patients with foot disorders.Material and methods The questionnaires the patients completed preoperatively included SEFAS, SF‑36, a general health survey questionnaire, and the Lower Extremity Functional Scale (LEFS). Patients were requested to complete the SEFAS questionnaire at 2 months of surgery to assess the sensitivity of the instrument. Based on the case histories clinical researcher recorded general and physical parameters of the patients to include gender, age, socio-demographic data, nature of the foot disorder, a dorsiflexion angle of the first metatarsophalangeal joint. To assess the reproducibility of the Russian version of the questionnaire, some patients were requested to complete the SEFAS questionnaire twice preoperatively with an interval of one day.Results The questionnaire was characterized by good internal consistency and reproducibility indicating acceptable reliability of the Russian version of SEFAS. Statistically significant correlations of varying strength were seen between the SF-36 scores and nearly all the selected questions of the SEFAS Russian version. Statistically significant correlations (moderate to weak) were observed between the LEFS total score and the selected SEFAS questions. Minimal clinically significant changes in MCID scored 3 in the assessment of clinical interpretability of the Russian version of SEFAS.Discussion The study demonstrated the reliability, validity and sensitivity of the Russian version of the SEFAS questionnaire. The questionnaire appeared to be an informative and clinically interpretable instrument for assessing foot in surgical adult patients with foot disorders.Conclusion The SEFAS questionnaire can be recommended for Russian trauma and orthopaedic practice to learn the patient's opinion of the condition.
Current state of the treatment problem in the patients with elbow joint contractures due to ossification
Authors: Petlenko I. S. , Shubnyakov I. I. , Fedyunina S. Yu. , Aliyev A. G. , Bilyk S. S. , Ryabinin M. V. 
Published: April 2024

Introduction Surgical treatment of stiff elbow caused by ossification often result in poor outcomes due to anatomical and physiological characteristics, significant functional load and higher patient requirements for the elbow functionality.The purpose was to determine ways of improved surgical treatment for patients with elbow contractures caused by ossification, based on an analysis of literature reporting surgical strategy and outcomes.Material and methods An internet search of PubMed, Medline, Elibrary.ru, CyberLeninka, Google Scholar, International Clinical Trials Registry of the US National Institutes of Health, ISRCTN Registry of International Standard Randomized Clinical Trial Numbers, German Clinical Trials Registry DRKS, WHO Registry was performed. Search words and phrases included elbow contracture, ossification, surgical treatment, stiff, elbow, surgical treatment, ossification. The search depth was 10 years.Results and discussion Some important parameters (recurrence of stiffness, pain, decreased quality of life, etc.) are reported as “very unassertive” in patients with stiff elbow due to ossification at mid and long terms (12–24 months or greater). Poor outcomes are reported in approximately 50 % of the cases due to the range of motion decreased to the preoperative level or less. Many patients (more than 90 % according to some authors) need a repeated surgery and are at risk for the stiff joint.Conclusion A critical analysis of the literature indicates lack of preoperative instrumentation examination of patients with use of new visualization methods (3D modeling). Preoperative examination and surgical planning based on additive technologies are essential for surgically treated patients with stiff elbow caused by ossification.