bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis Of Mechanical and Microstructural Properties Of Geopolymer Concrete Using Nano TiO2
Authors: Theja A. Ravi , Gopala K. V.S. , Murthy N R Dakshina , Potluri Sankar Babu , Sashidhar C. 
Published: April 2024

Abstract

Geopolymer concrete (GPC), an eco-friendly building material, is instinct by alkaline liquids to act as a binder in concrete. GPC evinces many outstanding properties such as rapid strength, less shrinkage, less creep, superior withstand against sulfate, and chloride attack. The present study is to explore the response of nano titanium dioxide (nano-TiO2) on Ground Granulated Blast Furnace Slag (GGBS) based GPC at ambient curing. As an initial study, GPC with 10 M was carried out for different ratios of Na2SiO3 to NaOH solutions between 1.5 to 3.5. Out of all mixes, the alkaline activator ratio harmonized to the highest compressive strength was ascertained to be at 2.5. This ratio was kept constant for further study in GPC by increasing the addition of nano TiO2 from 1–5% by weight of GGBS. The effect of nano TiO2 on strength properties, durability studies, and micro structural properties on GPC are studied and discussed at length in this paper.
Autonomous clonal seed production in the dicotyledonous Arabidopsis
Authors: Wang Kejian , Chen Wen-Qiang , Xu Liping , Liu Chaolei , Hong Zhengyuan , Lu Hongwei , Rao Yuchun , Liu Chun-Ming , Li Hong-Ju 
Published: April 2024

Abstract

Apomixis enables plants to produce seeds genetically identical to the parent, promising transformative prospects in plant breeding. Although autonomous synthetic apomixis has been successfully implemented in monocotyledonous rice, it has yet to be realized in other species, especially dicots. In this study, we achieved autonomous clonal seed production in Arabidopsis via genome editing, establishing the feasibility of autonomous synthetic apomixis in dicots and providing a novel and promising approach for utilizing heterosis in dicotyledonous crops.
Hábitos de vida, incapacidade física e a relação com a dor lombar crônica não específica
Authors: Araújo Mikael Gleidison de Melo , Fittipaldi Etiene Oliveira da Silva , De Ceballos Albanita Gomes da Costa , Dos Santos Washington José 
Published: April 2024

Objetivo: observar a relação existente entre hábitos de vida e incapacidade física e a relação desses dois fatores com a DLC não específica. Métodos: Tratou-se de um estudo transversal, exploratório e analítico, com uma amostra por conveniência de 50 indivíduos de ambos os sexos, com idade ≥ 18 anos. Os participantes foram avaliados quanto às questões socioeconômicas, demográficas e hábitos de vida; nível de incapacidade física através do questionário Roland-Morris (RM) e Intensidade da dor pela escala visual analógica (EVA). Resultados: A idade média de idade dos participantes foram de 56,9 (DP=8,87) anos, variando entre 34 e 72 anos. Destes, 90% (n=45) dos indivíduos eram do sexo feminino. A percepção de dor se dividiu entre moderada 30% (n=15) e intensa 70% (n=35). Observou-se associação estatisticamente significante entre o nível de dor e incapacidade física (RP 9,86, IC=1,46-66,47). Os indivíduos que não costumavam realizar atividades de lazer apresentaram também maior sensação subjetiva de dor lombar (DL) (RP 0,60, IC=0,37-0,95) e incapacidade física (RP 0,39, IC=0,18-0,88). Também foi observada associação estatisticamente significante entre os ser fumante e DL (RP 1,60, IC=1,25-1,99) e entre a incapacidade física e a DL (RP 1,88, IC=1,13-3,11). Não foi observada associação significativa entre a prática de exercício físico, consumo de bebida alcoólica e alimentação com os níveis de dor e incapacidade física. Conclusão: No presente estudo foi possível observar forte relação entre a dor e a incapacidade física, bem como o hábito de fumar e interferência na realização de atividades de lazer.
Distribution and transfer of organics in the coagulation–anaerobic hydrolysis–aerobic treatment process of cutting fluid wastewaters
Authors: Zhang Ru Yue , Yu Jing Jie , Han Zhuo Ran , Wang Zhi Rui , Wang Shao Po 
Published: April 2024

ABSTRACT

Two kinds of real cutting fluid wastewater samples (i.e., sample A and sample B) and two kinds of coagulants (i.e., polymerized aluminum chloride (PAC) and polymeric iron sulfate (PFS)) were studied during coagulation experiment, and the coagulation effluent of sample B with PAC was utilized for subsequent anaerobic hydrolysis–aerobic treatment, and the molecular weight (MW) distribution and ultraviolet (UV) absorption spectroscopy were used to explore the distribution and transfer of organics of each treatment unit. The results showed that sample A and sample B both mainly contained macromolecular organics with MW &gt; 100 kDa and small molecule organics with MW &lt; 3 kDa, and PAC had significant coagulation performance for organics with MW &gt; 100 kDa in both samples, while neither PAC nor PFS achieved good coagulation performance for the small molecule organics with MW &lt; 3 kDa in both samples. It could be inferred by UV spectra that the coagulation effluent of sample A and B might both contain organics with conjugated double bonds, monocyclic aromatic hydrocarbons, and the coagulation effluent of sample B might also contain polycyclic aromatic hydrocarbons and heterocyclic compounds with low MW. MW distribution analysis and the UV spectra results showed that biological treatment could further remove organics with conjugated double bonds and aromatic compounds with MW &lt; 3 kDa.
Forecasting water scarcity with an optimized Soil and Water Assessment Tool (SWAT) model under representative concentration pathway (RCP) scenarios
Authors: Li Cen , Guo Xin , Chen Liping , Khayatnezhad Majid , Gholinia Fatemeh 
Published: April 2024

Abstract
Water Supply issues a formal withdrawal in relation to the above article by Cen Li, Xin Guo, Liping Chen, Majid Khayatnezhad and Fatemeh Gholinia. This decision has been made due to concerns that were raised regarding potential citation manipulation due to inappropriate references, and significant authorship changes during peer review. The journal did not receive a satisfactory response to these concerns and as such the Editors-in-Chief no longer have confidence in the integrity of the article.
The IFT80/Hedgehog Pathway Regulates the Osteogenic-adipogenic Differentiation of Bone Marrow Mesenchymal Stem Cells
Authors: Jiang Mingyang , Zhang Ke , Hu Yang , Lu Shenyi , Wei Guiqing , Liu Kaicheng , Chen Chuanliang , Zou Xiaochong , Dai Yongheng , Gui Ying , Wu Jing , Bo Huan , Bo Zhandong 
Published: April 2024

Background:
Steroid-induced avascular necrosis of the femoral head
(SANFH) is a typical refractory disease that often progresses irreversibly and has a high
disability rate. Numerous studies have confirmed that abnormal osteogenic-adipogenic
differentiation of bone marrow mesenchymal stem cells (BM-MSCs) is one of the major
factors of SANFH. However, the mechanism remains to be elucidated.

Objectives:
This study aimed to investigate the function of the IFT80/Hedgehog pathway
in the osteogenic-adipogenic differentiation of BM-MSCs.

Methods:
Femoral head specimens of SANFH patients and femoral neck fractures (FNFs)
patients were collected to detect the expression of IFT80, Shh and osteogenic-adipogenic
differentiation-related genes by immunohistochemistry (IHC), western blot (WB)
and Reverse Transcription Quantitative Polymerase Chain Reaction (RT-qPCR). Based
on the rabbit SANFH model, the mRNA expression and protein level of IFT80 and Shh
were detected by RT-qPCR and WB. After the osteogenic-adipogenic differentiation
based on rabbit BM-MSCs, the IFT80, Gli, PPAR-γ, and Runx2 expression were detected.
Differences in alkaline phosphodiesterase activity, calcium nodule, quantification/distribution
of lipid droplets, expression of IFT80/Hedgehog axis, and the level of osteogenic-
adipogenic associated factors were determined after IFT80 overexpression.

Results:
RT-qPCR, WB and IHC revealed that IFT80 was highly expressed in the osteoblasts
and intra-trabecular osteocytes at the edge of trabeculae and in the intercellular
matrix of the bone marrow lumen; Shh was highly expressed in the osteoblasts and intra-
trabecular osteocytes at the edge of trabeculae. The Runx2 expression was low,
while the PPAR-γ expression was high in both human specimens and animal models of
SANFH, suggesting that the balance of osteogenic-adipogenic differentiation was dysregulated.
Rabbit BM-MSCs with stable overexpression of IFT80 showed increased alkaline
phosphatase activity after induction of osteogenic differentiation, increased calcium
nodule production, and decreased adipogenesis after induction of adipogenic differentiation.

Conclusion:
There is a dysregulation of the balance of osteogenic-adipogenic differentiation
in SANFH. IFT80 may inhibit adipogenic differentiation while promoting osteogenic
differentiation in rabbit BM-MSCs by activating the Hedgehog pathway.
Nanotechnology in Orthodontics: Unveiling Pain Mechanisms, Innovations,
and Future Prospects of Nanomaterials in Drug Delivery
Authors: Sharma Divya , Kumar Shiv , Garg Yogesh , Chopra Shruti , Bhatia Amit 
Published: April 2024

Abstract:
Orthodontic pain is characterized by sensations of tingling, tooth discomfort, and intolerance. According
to the oral health report, over forty percent of children and adolescents have undergone orthodontic
treatment. The efficacy of orthodontic treatment involving braces can be compromised by the diverse levels of
discomfort and suffering experienced by patients, leading to suboptimal treatment outcomes and reduced patient
adherence. Nanotechnology has entered all areas of science and technology. This review provides an
overview of nanoscience, its application in orthodontics, the underlying processes of orthodontic pain, effective
treatment options, and a summary of recent research in Nano-dentistry. The uses of this technology in
healthcare span a wide range, including enhanced diagnostics, biosensors, and targeted drug delivery. The reason
for this is that nanomaterials possess distinct qualities that depend on their size, which can greatly enhance
human well-being and contribute to better health when effectively utilized. The field of dentistry has also experienced
significant advancements, particularly in the past decade, especially in the utilization of nanomaterials
and technology. Over time, there has been an increase in the availability of dental nanomaterials, and a diverse
array of these materials have been extensively studied for both commercial and therapeutic purposes.
Novel Piperazine Derivatives as Potent Antihistamine, Anti-Inflammatory, and
Anticancer Agents, their Synthesis and Characterization
Authors: Rasheed Ameer Mohammed , Shetty Kannika Krishnappa , Roy Lairikyengbam Deepti , Kumar Jyotsna 
Published: April 2024

Introduction:
In this study, a series of novel piperazine derivatives were synthesised with high-to-good
yields, and their structural analogies were confirmed using FTIR, 1H-NMR, and LC-MS techniques.

Methods:
The synthesised compounds were evaluated for antioxidant and antimicrobial activities. Among the four
synthesised piperazine derivatives, compound PD-2 exhibited relatively good antioxidant activity, with an IC50
value of 2.396 μg/mL, while the other three derivatives showed moderate to low antioxidant activity. Furthermore,
compound PD-2 displayed antimicrobial activity against Pseudomonas aeruginosa, a gram-negative bacterium,
and Candida albicans, a fungus. However, all four compounds showed strong resistance against grampositive
bacteria, Staphylococcus aureus.

Results:
Additionally, compound PD-1 exhibited significant antihistamine activity, eliciting an 18.22% reduction
in histamine levels. Both PD-1 and PD-2 demonstrated noteworthy anti-inflammatory activity in a dosedependent
manner (5-10 μM), leading to the inhibition of nitrite production up to 39.42% and 33.7% at higher
concentrations (10 μM) and inhibition of tumour necrosis factor-alpha (TNF-α) generation up to 56.97% and
44.73% at 10 μM, respectively. Additionally, both novel molecules PD-1 and PD-2 effectively restrained the
growth of HepG2 cells in a manner that is dependent on the dosage up to 55.44% and 90.45% at the highest concentrations
(100 μg/mL), respectively.

Conclusion:
These findings substantiate the rationale for further investigation into the novel series of persuasive
piperazine analogues as potential agents with anti-inflammatory, antihistamine and anticancer properties.
Multimodality Imaging Evaluation of Nasal Rhabdomyosarcoma in Adults: A Case Report and Literature Review
Authors: Chen Lujiao , Chen Bo , Yu Shanlu , Zhao Zhenhua , Shen Liyijing 
Published: April 2024

Background:
Alveolar rhabdomyosarcoma (ARMS) predominantly affects adolescents
aged 10-15 years and is distinguished by its high aggressiveness and adverse prognosis
compared with other sarcomas. It exhibits a pronounced tendency for lymphatic and hematogenous
metastases at early stages. ARMS commonly manifests in the limbs and genitourinary
system, with occurrences in the head and neck region being relatively uncommon. The role of
CT, MRI, and 18F-FDG positron emission tomography combined with computed tomography
(PET/CT) in the diagnostic process of ARMS is yet to be fully established.

Case Report:
We report the case of a 49-year-old woman who presented with hematological
nasal discharge for one month. CT imaging revealed a soft tissue mass in the left nasal cavity.
MRI demonstrated a marginally hypo- to isointense signal on T1-weighted images, a hyperintense
signal on T2-weighted images, and heterogeneous enhancement post-contrast. 18F-FDG
PET/CT identified a hypermetabolic lesion located within the left nasal cavity. Surgical intervention
entailed the excision of the left intranasal mass and the skull base lesion. Postoperative
pathological analysis indicated ARMS.

Conclusion:
Sinus ARMS is notably malignant and associated with a dismal prognosis. Accurate
diagnosis depends on histopathological and immunohistochemical evaluation, complemented
by genetic analysis for specific chromosomal translocations and fusion genes. Imaging techniques,
including CT, MRI, and PET/CT, are crucial for assessing lesion extent and metastasis,
supporting disease diagnosis, informing treatment choices, facilitating surgical planning, and
monitoring response to therapy.
Prospects of Targeted Gene/Drug Delivery Vectors and their Potential Use in
Cancer Therapy
Authors: Muripiti Venkanna , Ravula Venkatesh , Patri Srilakshmi V. 
Published: April 2024

Abstract::
Targeted gene and drug delivery vector developments have completely changed the therapeutic intervention by providing previously unheard-of
levels of accuracy and efficacy in treating various illnesses. Cancer is one such fatal disease plaguing people across the globe. This review article
highlights the potential uses of targeted delivery systems in the field of cancer treatment while providing a thorough examination of the state of the
art. Chemotherapy and radiation therapy are being used to cure cancer, yet they can be frequently ineffective and have serious adverse effects.
Novel techniques for therapy have to be designed. Existing chemotherapy is being superseded by particular gene therapy used for genetic diseases.
Therefore, to deliver the therapeutic agent to the targeted place, a carrier or vector is needed. The current review is focused on targeted gene/drug
delivery vectors concerning i) cationic lipids that target single receptors ii) ligand-peptide conjugated cationic lipids iii) modalities for targeting
dual ligands for cancer therapy iv) passive versus active targeting v) properties of nano-formulations for gene and drug delivery. The most recent
developments in lipid customization for certain receptors overexpressed in cancer cells are covered to reduce side effects and improve treatment
results. By delving into the above areas, this review presents a broad overview of the changing field of cationic lipids in cancer therapy, giving
scientists and medical professionals insightful knowledge about the many strategies for ensuring precise and efficient drug delivery in the battle
against cancer.
Multifunctional Deep Eutectic Solvent-Catalyzed Synthesis of Dihydropyrimidinethiones: A Sustainable Approach for Green and Efficient Reactions
Authors: Khandebharad Amol U. , Arde Satyanaryan M. , Pardeshi Shrutika C. , Dhotre Bharat K. , Sarda Swapnil R. 
Published: April 2024

Background:
This study investigates the synthesis of dihydropyrimidinethiones using
a multifunctional deep eutectic solvent (DES) composed of Choline chloride (ChCl) and ammonium
thiocyanate. This DES serves as a catalyst, solvent, and reagent, providing a simple, highyielding,
and environmentally friendly method for dihydropyrimidinethione synthesis. The use
of DES in this capacity offers several advantages, including reduced environmental impact, high
efficiency, and ease of use, highlighting its potential as a sustainable alternative in organic synthesis.

Objective:
The objective of this study is to investigate the application of a deep eutectic solvent
(DES) composed of ChCl and ammonium thiocyanate as a catalytic solvent and reagent system
for synthesizing dihydropyrimidinethiones. The aim is to simplify the reaction setup, improve
yields, and enhance the green metrics of the process.

Methods:
ChCl and ammonium thiocyanate were combined to form a DES catalyst-solvent system.
Dihydropyrimidinethiones were synthesized in one-pot reactions at ambient temperature.
Green metrics and DES recovery were evaluated. Comparative analysis with traditional methods
was conducted.

Results:
The DES efficiently catalyzed dihydropyrimidinethione synthesis with high yields. Simplified
reaction setup, safe solvent properties, and favorable green metrics. DES was recoverable
and reusable, outperforming traditional methods in efficiency and eco-friendliness.

Conclusion:
The ChCl and ammonium thiocyanate DES demonstrated remarkable efficiency and
eco-friendliness in dihydropyrimidinethione synthesis. The toxicity-free, multifunctional roles of
the DES, serving as a catalyst, solvent, and reagent, highlight its novelty and potential as a sustainable
alternative in organic chemistry. This study simplifies the synthesis process and improves
yields and green metrics, showcasing the DES as a promising candidate for future research
and industrial applications.
Effectiveness of Mobile-Based Progressive and Fixed Physical Activity on Depression, Stress, Anxiety, and Quality of Life Outcomes Among Adults in South Korea: Randomized Controlled Trial
Authors: Lee Ye Hoon , Kim Hyungsook , Hwang Juhee , Noh Sihyeon 
Published: April 2024

Background
Depression acts as a significant obstacle to the overall well-being of individuals. Given the significant consequences, timely recognition and proactive steps to manage symptoms of depression become essential. Such actions not only reduce personal distress but also play a crucial role in reducing its far-reaching impact on society as a whole.

Objective
In response to this concern, the objective of this study was to explore the use of mobile-based interventions as a possible remedy. More specifically, this study aimed to investigate the effectiveness of 2 types of physical activity (PA), progressive and fixed, within a mobile-based app on depression, perceived stress, anxiety, physical health, and psychological health, aiming to contribute to the optimization of mental health benefits.

Methods
Participants (N=60; mean age 25.29, SD 6.10 years) were recruited using a combination of web-based and offline methods, and the study lasted for 8 weeks. The baseline and posttest questionnaires were administered to all participants. The participants were randomly assigned to 1 of the 3 groups: progressive group (n=20; performing mobile-based progressive PA), fixed group (n=20; performing mobile-based fixed intensity PA), and control group C (n=20). Data analysis involved comparing scores between the experimental and control groups using a one-way ANOVA, paired sample t tests (2-tailed), and repeated measures ANOVA with a 3 (group)×2 (time) design.

Results
The findings revealed significant improvements in mental health indicators among participants engaged in both fixed and progressive PA groups compared with the control group. However, the fixed PA group demonstrated more significant reductions in symptoms. Specifically, the progressive PA group showed significant reductions in depression (F1,36=6.941; P=.01; ηp2=0.16) and perceived stress (F1,36=5.47; P=.03; ηp2=0.13), while the fixed PA group exhibited significant reductions in depression (F1,37=5.36; P=.03; ηp2=0.12), perceived stress (F1,37=7.81; P=.008; ηp2=0.17), and general anxiety disorder (F1,37=5.45; P=.03; ηp2=0.13) compared with the control group.

Conclusions
This study underscores the potential of mobile-based PA in improving mental health outcomes. The findings offer significant insights for mental health professionals and researchers aiming to optimize mental well-being through innovative mobile therapies.

Trial Registration
Clinical Research Information Service KCT0009100; https://tinyurl.com/mr33fmur
Correlation between oral cavity volume and upper airway changes in skeletal Class III patients undergoing bimaxillary orthognathic surgery: a pilot cone-beam computed tomography study
Authors: Li Gen , Chen Zhenwei , Li Yingyi , Cai Guanhui , Ruan Xiaolei , Wang Ting , Guan Zhaolan , Sun Lian , Wang Wei , Sun Wen , Wang Hua 
Published: April 2024

ABSTRACT

Objectives
To evaluate changes of the upper airway and oral cavity volumes in patients with skeletal Class III malocclusion undergoing bimaxillary orthognathic surgery, and to analyze the correlation between postoperative upper airway decrease and the amount of jaw movement and oral cavity volume reduction.

Materials and Methods
Thirty patients (16 males and 14 females) undergoing bimaxillary surgery were included. Three-dimensional reconstruction of the upper airway and oral cavity were performed using preoperative (T0) and postoperative (T1) (6 months) cone-beam computed tomography scans.

Results
The volume, sagittal area and minimum cross-sectional area of the upper airway were diminished (P &lt; .001). The decrease in volume and minimum cross-sectional area in the oropharyngeal region of the upper airway were weakly correlated with B-point posterior movement (P &lt; .05). Total oral cavity volume was decreased, with maxillary oral volume increasing and mandibular oral volume decreasing (P &lt; .001). Upper airway decrease was highly correlated with total oral volume reduction and mandibular oral volume reduction, with the most significant correlation being with total oral volume reduction (P &lt; .001).

Conclusions
Class III bimaxillary surgery reduced the volume, sagittal area, and minimum cross-sectional area of the upper airway as well as oral cavity volume. Upper airway changes were weakly correlated with anterior-posterior mandibular movement but significantly correlated with oral cavity volume changes. Thus, oral cavity volume reduction is a crucial factor of upper airway decrease in patients with skeletal Class III malocclusion undergoing bimaxillary orthognathic surgery.