bluuebunny/crossref_metadata_2025_split huggingface dataset:
In‐syringe homogeneous liquid‐phase microextraction followed by filtration‐based phase separation for on‐site extraction of chloroanilines from water samples
Authors: Yıldız Elif , Çabuk Hasan 
Published: May 2024

This study introduces a new in‐syringe homogeneous liquid‐phase microextraction method for the rapid on‐site extraction of chloroanilines from water samples. Extraction was performed using a plastic syringe, eliminating the use of any electrical power source. Di‐(2‐ethylhexyl) phosphoric acid (DEHPA) served as the extractant. The process initially involved dissolving DEHPA in an alkaline solution to obtain a homogeneous solution. Subsequently, the sodium salt of DEHPA was precipitated by salting‐out, and the resulting heterogeneous mixture was filtered using a syringe filter. The precipitate containing the analytes was then dissolved in methanol for analysis by high‐performance liquid chromatography. Under optimal conditions, extraction recovery for chloroanilines ranged from 26% to 71%. Method linearity was evaluated within a concentration range of 1.0–100 µg/L, resulting in coefficients of determination exceeding 0.9987 for all analytes. Method detection limits ranged from 0.28 to 0.41 µg/L. Intra and inter‐day precision values were below 9.5% and 10.8%, respectively. The developed method was applied to determine chloroanilines in real waters, yielding acceptable recoveries ranging from 80% to 109% for spiked tap, rain, and stream waters. Additionally, the method was successfully employed for on‐site extraction of target contaminants, demonstrating no statistically significant differences compared to laboratory results.
Gifts that give twice are not twice as nice: Consumers avoid socially responsible gifts for picky recipients
Authors: Chin Shih‐Chun (Daniel) , Wang TzuShuo Ryan , Ho Cony Ming‐Shen 
Published: May 2024

AbstractGift decisions are challenging. Consumers need to gauge their recipients' preferences—a task that could be especially tough when the recipients are picky. In addition, gift decisions involve consideration of many gift attributes, such as whether the gifts also support worthy causes (i.e., socially responsible gifts). In this research, we examine how givers' decision to give socially responsible gifts is impacted by how picky the recipients are. Five studies provide convergent evidence that gift‐givers are less likely to choose socially responsible gifts for picky recipients because they are perceived as lower in interpersonal warmth. Supporting our theory, the effect attenuates for gift‐givers attend less to interpersonal warmth (i.e., high in social dominance orientation) and when cues indicating recipient warmth are salient. We conclude by discussing the contributions to the gift‐giving and consumer pickiness literature and the practical implications for marketers promoting socially responsible gifts.
Diagnosis of Arboleda‐Tham syndrome by whole‐exome sequencing in an Asian girl with severe developmental delay
Authors: Wang Qingran , Zhang Yujiao , Li Li , Yang Ning 
Published: May 2024

AbstractObjectiveThis study aims to report a severe phenotype of Arboleda‐Tham syndrome in a 20‐month‐old girl, characterized by global developmental delay, distinct facial features, intellectual disability. Arboleda‐Tham syndrome is known for its wide phenotypic spectrum and is associated with truncating variants in the KAT6A gene.MethodsTo diagnose this case, a combination of clinical phenotype assessment and whole‐exome sequencing technology was employed. The genetic analysis involved whole‐exome sequencing, followed by confirmation of the identified variant through Sanger sequencing.ResultsThe whole‐exome sequencing revealed a novel de novo frameshift mutation c.3048del (p.Leu1017Serfs*17) in the KAT6A gene, which is classified as likely pathogenic. This mutation was not found in the ClinVar and HGMD databases and was not present in her parents. The mutation leads to protein truncation or activation of nonsense‐mediated mRNA degradation. The mutation is located within exon 16, potentially leading to protein truncation or activation of nonsense‐mediated mRNA degradation. Protein modeling suggested that the de novo KAT6A mutation might alter hydrogen bonding and reduce protein stability, potentially damaging the protein structure and function.ConclusionThis study expands the understanding of the genetic basis of Arboleda‐Tham syndrome, highlighting the importance of whole‐exome sequencing in diagnosing cases with varied clinical presentations. The discovery of the novel KAT6A mutation adds to the spectrum of known pathogenic variants and underscores the significance of this gene in the syndrome's pathology.
Quantitative evaluation of factors influencing the 3 Hz repetitive nerve stimulation test in patients with amyotrophic lateral sclerosis
Authors: Zhang Jinghong , Yang Fei , Li Mao , Zhu Yahui , Huang Xusheng 
Published: May 2024

AbstractIntroduction/AimsPrevious studies have suggested that treatments targeting the neuromuscular junction (NMJ) may play a role in the treatment of amyotrophic lateral sclerosis (ALS). However, factors impacting repetitive nerve stimulation (RNS), a technique to evaluate NMJ function, have yet to be fully elucidated. We aimed to identify independent factors contributing to the decremental response of the accessory nerve and evaluated its value in ALS clinical practice.MethodsA total of 626 patients who were diagnosed with ALS and underwent 3 Hz RNS tests on the accessory nerve were enrolled. Data on their clinical and electrophysiological indicators were divided into a training set (collected from June 2016 to December 2022) and a test set (collected from January to August 2023). Stepwise regression was used in independent variable selection and model building.ResultsForty‐two percent of patients had a decrement larger than 10% and 24% had a decrement larger than 15%. Onset age, sex, onset site, forced vital capacity (FVC) and motor unit potential (MUP) duration were independent factors contributing to the results of the RNS test. MUP duration had the greatest impact on decremental response, followed by FVC and onset age. The decremental response in females was larger than in males. Upper limb onset was found to contribute more to the decrement than lower limb or bulbar onset.DiscussionIn patients with ALS, NMJ safety factor is reduced during re‐innervation. Decremental response is affected by multiple factors, which needs to be considered in clinical trials targeting the NMJ in these patients.
Strategies for optimizing interfacial thermal resistance of thermally conductive hexagonal boron nitride/polymer composites: A review
Authors: Jia Pingping , An Lulu , Yu Lang , Pan Yaokun , Fan Huiqing , Qin Luchang 
Published: May 2024

AbstractWith the continuous development of high‐end electronic information technologies such as 5G communications, thermal management is an urgent issue in the electronic and circuit industries due to the miniaturization, functionalization and integration. Recently, polymer‐based composites with the fillers of hexagonal boron nitride (h‐BN) have been regarded as promising candidates resulting from their excellent thermal conductivity (TC), good insulation and remarkable comprehensive properties. However, the high surface inertness of h‐BN itself, incompatibility with matrix and other fillers and mismatch of phonon‐spectrum will bring about the matrix/filler and filler/filler interfacial thermal resistance (ITR), which will greatly decline the TC of the composites, and limit their thermal management ability. Therefore, how to design, regulate and improve the interfacial states in composites and eventually enhance the TC is a current challenge. Researchers have made great effort to reduce the ITR of the composites to improve their TC. However, a comprehensive summary and analysis of researches on the improvement methods of the interface states in composites in the past 3 years is still lacking. In this work, the commonly used mechanism models, and simulation methods for calculating and predicting TC was summarized. From perspectives of Synthesis of h‐BNNs, modification, orientation, bridging and three‐dimensional structures construction, we reviewed strategies for improving the interface states in composites, and focused on the ITR regulation and TC improvement. The improvement effects of various methods on TC were compared. The development trend of high TC composite materials was prospected.Highlights
Crystallinity, defect, size, flatness, thickness of hexagonal boron nitride nanosheets (BNNSs) affect interfacial thermal resistance (ITR).
Nature of interaction between adjacent layers of BNNS need exploited.
Interface and defect are root cause of extra phonon scattering.
Shape, density, surface area, distribution and compatibility reduce ITR.
Theory, model, simulation methods need developed on different levels.
Design, preparation, and mechanical properties of glass fiber reinforced thermoplastic self‐anchor plate cable exposed in alkaline solution environment
Authors: Zhang Zhonghui , Ji Qikang , Guo Zhengyue , Li Chenggao , Guo Rui , Tian Jingwei , Zhang Zhuo , He Taipeng , Xian Guijun 
Published: May 2024

AbstractThe reliable anchorage and long‐term durability of high‐performance fiber reinforced polymer composites were the decisive factors for engineering applications owing to the anisotropy of materials and the complexity of service environment. In this paper, an innovative glass fiber reinforced polypropylene (GFRPP) self‐anchor plate cable was developed to utilize the high toughness/durability of thermoplastic resin and self‐anchor load‐bearing system. The effects of different reinforcement methods and cable arc angles (10°, 20°, and 30°) on mechanical properties of plate cable were investigated. Water absorption behavior and mechanical properties immersed in alkali solution were tested to evaluate its long‐term service behavior. The thermogravimetric and surface morphology analysis were conducted to reveal the performance evolution mechanism. The results showed through the combination of secondary melting, carbon fiber winding confinement and epoxy reinforcements, the splitting failure of transition zone and interlaminar cracking failure of straight zone for plate cable were effectively avoided. The tensile strength retention of plate cable for arc angles of 10°, 20° and 30° were 45.6%, 41.3%, and 34.0% of GFRPP plate, respectively. Larger arc angle increased the curvature of arc‐straight transition zone and stress concentration near the straight section, leading to interlaminar splitting failure of plate cable at weak transition zone. The tensile strength of plate cable with the immersion time deteriorated obviously until the lowest retention of 29.7%. The degradation mechanism was mainly due to the etching of glass fibers in alkali solution and the formation of pores and internal defects, including fiber/resin interface debonding and resin swelling. The research results were of significance for solving the anchoring problems and promoting the long‐term service reliability in bridge applications.Highlights
The mold can realize reliable molding of glass fiber reinforced polypropylene cables after the reinforcements.
The tensile strength retention of plate cable was up to 34.0%–45.6% of plate.
Larger arc angle increased the stress concentration near the straight section.
Non‐polar polypropylene plate was proved to have better hydrophobic performance.
The degradation mechanism of plate cable in alkali solution was revealed.
The effectiveness of automated adjustment of inspired oxygen in preterm infants receiving respiratory support compared with manual: A systematic review and meta‐analysis
Authors: Zhang Yihan , Du Yuxuan , Shi Yuan 
Published: May 2024

AbstractPreterm infants may need supplemental oxygen due to immature lungs. Regardless of the type of oxygen therapy used, bedside clinicians frequently adjust the FiO2 level. Automatic oxygen management is progressively developing as a viable alternative to these corrections. The purpose of this study is to compare the efficacy and safety of automated versus manual oxygen control in preterm infants receiving respiratory support. All the studies were searched from PubMed, Web of Science, Cochrane Library, Embase, CNKI, Wan Fang, VIP, and CBM on 7 May 2022. PICOS criteria were as follows: (P) participants were preterm infants receiving respiratory support; (I) intervention was automatic oxygen control; (C) comparator mode was manual oxygen control; (O) the primary outcome was the percentage of time within the target pulse oxygen saturation range; (S) randomized clinical trials. Sixteen studies were included in this meta‐analysis. The results showed that automated oxygen control can increase the percentage of time spent within the target SpO2 range while reducing the percentage of time spent above the target SpO2 range, the percentage time of hypoxemia, and manual FiO2 adjustments/hour. No significant difference was observed in the percentage of time spent below the target SpO2 range, incidence of bradycardia, and the mean SpO2 or mean FiO2 level. Automatic oxygen control can improve preterm infants' oxygen saturation, reduce periods of hypoxemia and the percentage of time spent above the target SpO2 range, and ease the workload of medical staff without affecting the mean FiO2 and mean SpO2 levels.
Exploiting new strategies in combating head and neck carcinoma: A comprehensive review on phytochemical approaches passing through PI3K/Akt/mTOR signaling pathway
Authors: Iranpanah Amin , Majnooni Mohammad Bagher , Biganeh Hossein , Amirian Roshanak , Rastegari‐Pouyani Mohsen , Filosa Rosanna , Cheang Wai San , Fakhri Sajad , Khan Haroon 
Published: May 2024

AbstractRecently, malignant neoplasms have growingly caused human morbidity and mortality. Head and neck cancer (HNC) constitutes a substantial group of malignancies occurring in various anatomical regions of the head and neck, including lips, mouth, throat, larynx, nose, sinuses, oropharynx, hypopharynx, nasopharynx, and salivary glands. The present study addresses the phosphoinositide 3‐kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway as a possible therapeutic target in cancer therapy. Finding new multitargeting agents capable of modulating PI3K/Akt/mTOR and cross‐linked mediators could be viewed as an effective strategy in combating HNC. Recent studies have introduced phytochemicals as multitargeting agents and rich sources for finding and developing new therapeutic agents. Phytochemicals have exhibited immense anticancer effects, including targeting different stages of HNC through the modulation of several signaling pathways. Moreover, phenolic/polyphenolic compounds, alkaloids, terpenes/terpenoids, and other secondary metabolites have demonstrated promising anticancer activities because of their diverse pharmacological and biological properties like antiproliferative, antineoplastic, antioxidant, and anti‐inflammatory activities. The current review is mainly focused on new therapeutic strategies for HNC passing through the PI3K/Akt/mTOR pathway as new strategies in combating HNC.
Novel quantized iterative learning control based on spherical polar coordinates
Authors: Huo Niu , Shen Dong , Wang JinRong 
Published: May 2024

AbstractThis study investigates the iterative learning control method for discrete‐time systems with data quantization, and it employs a quantizer based on spherical polar coordinates. The quantizer uses spherical polar coordinates to transform an unquantized signal into one with a predetermined quantization level. The quantization capability is dependent on the size of the support sphere, which is dynamically adjustable. In the scenarios of system output quantization, general quantization, and tracking error quantization, the learning control schemes are developed with consideration of the smallest sphere quantization features. The radii of the support spheres are designed independently based on the characteristics of the quantized signals (system output, control input, tracking error). The findings suggest that the system can achieve a bounded error convergence in the scenarios of system output and general quantization. In the context of quantization in tracking error, it is achievable to attain tracking performance with zero error. The example of a permanent magnet synchronous motor is provided to illustrate the findings of the study.
A complete homogenization of water temperatures during widespread flooding
Authors: Myrvold Knut Marius 
Published: May 2024

AbstractThermal regimes can vary substantially across small geographic distances in rivers, and the factors responsible for creating a diverse thermal landscape can operate on multiple spatial and temporal extents. This short communication reports on the temperature dynamics in seasonal, off‐channel habitats in the lower reach of the Gudbrandsdalslågen River in South‐Eastern Norway (61 oN). The river is ordinarily characterized by a snowmelt‐driven hydrograph but was subjected to widespread, rain‐driven flooding in August 2023. At the onset of spring runoff in mid‐May, the differences between cooler and warmer sites exceeded 5°C (range 3–10°C) and continued to diverge until early July (range 6–21°C). Differences persisted through the regular rain‐driven spates in summer but were entirely diminished during the flood which started on August 7. By August 10, the water temperatures at all 14 sites had converged at 12.3°C. The homogenization was likely the result of the sheer volume of runoff through Gudbrandsdalslågen, overriding any locally modulating factors such as groundwater inputs and isolation from the main channel. This suggests a relatively strong influence of locally modulating factors in the study area under normal hydrological conditions in summer, and a complete dominance of runoff temperature during the flooding event. Disruptive events such as flooding can hence periodically revert the thermal heterogeneity by changing the relative importance of the factors that create patchy thermal regimes, with potential ramifications for aquatic organisms that occupy relatively warmer habitat patches in summer.
Towards a cleaner and sustainable Europe and Central Asia: An investigation of the logistics‐environment nexus
Authors: Shamout Mohamed Dawood 
Published: May 2024

AbstractThe logistics industry is the backbone of global trade and is crucial for the attainment of economic progress across the world. However, the industry involves activities that increase the consumption of energy resources including fossil fuels, which harms the environment. Thus, with a special focus on Europe and Central Asia, this study explores the logistics‐environment by evaluating the impact of logistics performance (LP) on environmental performance (EP) while controlling for key macroeconomic indicators such as income, trade openness, foreign direct investment, and industrialization. The motivation for this study is derived from the United Nations Sustainable Development Goals (SDGs‐11 and 13) which highlight sustainability and climate change mitigation. Using Poisson pseudo maximum likelihood with high‐dimensional fixed effects (PPMLHDFE) for 47 European and Central Asian countries over the period 2007–2018, the findings revealed that the overall logistic performance, and some of its components—customs, trade, and transport infrastructure, and tracing and tracking have a significant positive impact on the overall EP, environmental health, and ecosystem vitality. Additionally, the study confirms the detrimental effects of economic growth, trade, and industrialization on environmental quality and health from logistics and supply chain management (SCM) perspectives. Further policy caveats and suggestions are elucidated in the concluding section.
Pressureless Welding of Temperature‐Invariant Multifunctionality Body Based on Hydroxyl‐Functionalized Boron Nitride Nanosheets and Bifunctional Monoethanolamine Cross‐linker
Authors: Cao Chaochao , Yang Jingwen , Yang Shaobo , Yan Song , Liu Chaoze , Wang Dong , Xue Yanming , Qu Xiongwei , Tang Chengchun 
Published: May 2024

AbstractBulk hexagonal boron nitride (h‐BN) ceramics with structural integrity, high‐temperature resistance and low expansion rate are expected for multifunctional applications in extreme conditions. However, due to its sluggish self‐diffusion and intrinsic inertness, it remains a great challenge to overcome high‐energy barrier for h‐BN powder sintering. Herein, a cross‐linking and pressureless‐welding strategy is reported to produce bulk boron nitride nanosheets (BNNSs) ceramics with well‐crystalized and dense B–N covalent‐welding frameworks. The essence of this synthesis strategy lies in the construction of >B─O─H2C─H2C─H2N:→B< bond bridge connection structure among hydroxyl functionalized BNNSs (BNNSs‐OH) using bifunctional monoethanolamine (MEA) as cross‐linker through esterification and intermolecular‐coordination reactions. The prepared BNNSs‐interlaced ceramics have densities not less than 1.2 g cm−3, and exhibit exceptional mechanical robustness and resiliency, excellent thermomechanical stability, ultra‐low linear thermal expansion coefficient of 0.06 ppm °C−1, and high thermal diffusion coefficient of 4.76 mm2 s−1 at 25 °C and 3.72 mm2 s−1 at 450 °C. This research not only reduces the free energy barrier from h‐BN particles to bulk ceramics through facile multi‐step physicochemical reaction, but also stimulates further exploration of multifunctional applications for bulk h‐BN ceramics over a wide temperature range.
Robust Amide‐Linked Fluorinated Covalent Organic Framework for Long‐Term Oxygen Reduction Reaction Electrocatalysis
Authors: Jiménez‐Duro Miguel , Martínez‐Periñán Emiliano , Martínez‐Fernández Marcos , Martínez José I. , Lorenzo Encarnación , Segura José L. 
Published: May 2024

AbstractThe high energy demand of the evolving world opens the door to develop more sustainable and environmentally friendly energy sources. Oxygen reduction reaction (ORR) is a promising candidate, being the 2e− pathway of great interest for the green production of hydrogen peroxide. Metal‐free covalent organic frameworks (COFs) electrocatalysts present a suitable alternative to substitute the noble‐metals more commonly employed in this application. However, the lability of the linkages building up the framework raises an issue for their long‐term use and application in aggressive media. Herein, a stable amide‐linked COF is reported through post‐synthetic modification of a previously reported imine‐linked COF proven to be effective as an electrocatalyst, enhancing its chemical stability and electrochemical response. It is found that after the linkage transformation, the new electrocatalyst displays a higher selectivity toward the H2O2 production (98.5%) and an enhanced turnover frequency of 0.155 s−1, which is among the bests reported to date for metal‐free and COF based electrocatalysts. The results represent a promising step forward for metal‐free non pyrolyzed electrocatalysts, improving their properties through post‐synthetic linkage modification for long‐term operation.