bluuebunny/crossref_metadata_2025_split huggingface dataset:
Honokiol as an α-glucosidase inhibitor
Authors: Zhu Hua , Zhong Xin 
Published: June 2024

Honokiol, a naturally occurring compound from Magnolia obovata Thunb., has many biological activities, but its anti-α-glucosidase activity is still unclear. Therefore, we determined its inhibitory effects against α-glucosidase. Activity assays showed that honokiol was a reversible mixed-type inhibitor of α-glucosidase, and its IC50 value was 317.11 ± 12.86 μM. Fluorescence results indicated that the binding of honokiol to α-glucosidase caused a reduction in α-glucosidase activity. 3D fluorescence and CD spectra results indicated that the binding of honokiol to α-glucosidase caused conformational change in α-glucosidase. Docking simulated the detailed interactions between honokiol and α-glucosidase, including hydrogen and hydrophobic bonds. All findings showed that honokiol could be used as a natural inhibitor to develop α-glucosidase agents.
Pre-exercise cryotherapy reduces myoglobin and creatine kinase levels after eccentric muscle stress in young women
Authors: Kusmierczyk Justyna , Wiecek Magdalena , Bawelski Marek , Szygula Zbigniew , Rafa-Zablocka Katarzyna , Kantorowicz Malgorzata , Szymura Jadwiga 
Published: June 2024

Introduction: The aim of this study was to investigate the effect of pre-exercise whole-body cryotherapy (WBC) on muscle damage indicators following eccentric treadmill exercise in young women.Methods: Twenty-seven participants underwent two 1-h downhill treadmill runs, replicating 60% of their maximal oxygen uptake, with a 4-week intermission for recovery and treatment application. In this intermission, one group underwent 20 sessions of WBC, delivered five times a week at −120°C for 3 min each, while the comparison group received no such treatment. Markers of muscle injury—serum myoglobin concentration, creatine kinase and lactate dehydrogenase activity and also uric acid, and cell-free DNA concentration—were measured before and after downhill runs.Results: The study observed a notable reduction in post-exercise myoglobin and CK levels in the WBC group after the second running session.Discussion: The results suggest that WBC can have a protective effects against muscle damage resulting from eccentric exercise.
The effect of a collective competence intervention on collective efficacy, psychological wellbeing, and social wellbeing: a quasi-experimental study of a sample of healthcare workers during the COVID-19 crisis
Authors: Campos María Lourdes , Bolgeri Pedro , Bascur Axel 
Published: June 2024

BackgroundThe health crisis associated with COVID-19 led to a period of increased demand on the operational and social organization of healthcare centers, which often had a negative impact on the psychological and social wellbeing of healthcare workers. In order to tackle this issue, an intervention plan was designed to develop collective competences through various participatory strategies. This study sought to determine the effect of this intervention on the variables collective efficacy, psychological wellbeing, and social wellbeing in healthcare workers by performing a pretest and posttest comparison with a control group.MethodThe variables were evaluated using a non-probability, purposive sample of 80 healthcare workers from three Family Healthcare Centers (CESFAM) located in the Coquimbo Region, Chile, within health crisis context. The intervention group was composed of voluntary participants, while the control group only completed the evaluations. The intervention consisted in 6 training workshops focused on improving collective management, group synergy, collaborative problem-solving, communicative strategies, and overall team care.ResultsThe analysis shows that the collective competence intervention had a positive effect on the collective efficacy, psychological wellbeing, and social wellbeing of the participating healthcare workers during the COVID-19 crisis. Only specific factors of these variables did not undergo a significant impact.ConclusionThe results of this study suggest that interventions aimed at improving collective organizational competences, apart from increasing collective efficacy, can have a positive impact on healthcare workers' psychological and social wellbeing in a context of occupational adversity.
Cultivating insight and engagement: exploring the role of Trait Emotional Intelligence in Chinese art education
Authors: Wang Cong 
Published: June 2024

BackgroundThe present study focuses on the unique role of insight and Trait Emotional Intelligence in the realm of art education in China. Insight, traditionally associated with clinical outcomes such as mastering symptoms, developing adaptive behaviors, and enhancing quality of life, is newly contextualized in this study within the framework of art education. The expansion of insight research into areas like Social Psychology reflects its relevance beyond clinical settings, particularly in educational environments where creativity and emotional intelligence are pivotal.AimIn Chinese art education, insight is crucial not just for personal growth but also for professional development, integrating the understanding of emotions, culture, and artistic expression. This study explores how Trait Emotional Intelligence fosters insight and engagement in art students, underscoring its transformative impact on their educational and professional journey in the art world.MethodsUsing a sample of Chinese art education students at University level (N = 881), that answered a quantitative self-report questionnaire, statistical procedures are applied to test the relationships between Trait Emotional Intelligence, Insight orientation, and students’ academic engagement.ResultsIn the structural model, the path from Trait Emotional Intelligence to Insight Orientation was significant, indicating a positive relationship. Students’ Engagement was significantly predicted by Insight Orientation and Trait Emotional Intelligence.ImplicationsThis finding corroborates theoretical assertions that individuals with higher emotional intelligence are more inclined to have enhanced insight. The findings of the present study extend beyond the field of Art education, allowing us to provide a broad spectrum of social implications for Higher Education institutions.
The darkness of reacculturation: examining factors influencing depression among Chinese international student returnees in the post-COVID-19 era
Authors: Jin Ruining , Wei Jie , Wang Xuanyi , Le Tam-Tri 
Published: June 2024

IntroductionIn the aftermath of the COVID-19 pandemic, the reintegration of Chinese international student returnees intersects with China’s critical effort to combat a significant brain drain of highly skilled talents, highlighting an unprecedented psychological battleground. This convergence underscores the urgent need for nuanced research to navigate the uncharted territory of their mental health.MethodsEmploying Bayesian analysis supported by Markov Chain Monte Carlo (MCMC) algorithms, this study examined depression prevalence and associated factors among 1,014 Chinese returnees. The sample comprised 44.87% male participants (455), 51.58% female participants (523), and 3.55% identifying as “Others” (36), with an age distribution of 61.74% aged 18-30 (626), 28.80% aged 31-40 (292), and 9.47% aged 41-50 (96). The mean age of participants was 29.6 years, ranging from 18 to 50 years. PHQ-9 diagnoses revealed alarming levels of depression, with 47.9% exhibiting a moderately severe degree of depressive disorder.ResultsOur findings highlight the intricate interplay between identity clusters— “homestayers” (those leaning towards a Chinese cultural identity), “navigators” (those with a bicultural identity), and “wayfarers” (those leaning towards a foreign cultural identity)—and the likelihood of depression. Specifically, homestayers showed a clear and strong negative association, navigators demonstrated a positive association, and wayfarers had a positive yet unclear correlation with depression levels. Furthermore, acculturation, age, and gender showed no significant effects, whereas education mildly mitigated depression.DiscussionBased on these findings, we suggest the implementation of better-tailored mental health support and policies to facilitate smoother reintegration.
The inductive effect of musical mode types on emotions and physiological responses: Chinese pentatonic scales versus Western major/minor modes
Authors: Jiang Yihe , Zheng Maoping 
Published: June 2024

BackgroundThe value of music lies in its ability to evoke emotions. People can gain emotional experiences in music and can also regulate their own emotions through music. Music has its own structural rules, and exploring the relationship between musical structure and emotions is an important approach to understanding the mechanism of music-induced emotions. Musical mode refers to the arrangement of intervals around the tonic, presenting different musical modes based on the central tone and the arrangement of intervals, including Chinese pentatonic modes and Western major and minor modes. Musical morphology indicates significant differences in the construction intensity of traditional Chinese pentatonic modes and major and minor modes, affecting their mode forms and thus determining their adaptability to external influences.AimsExploring the modalities of music and the effects of individual music training experiences on emotion induction; validating whether musical modes exhibit cross-cultural universality in the process of emotion induction.MethodThis study recruited 65 university students as participants (34 with music training experience, 31 without music training experience). Through a passive listening paradigm using the GEMS and combined with a biofeedback equipment, it explored the differences in behavioral and physiological indicators (skin conductance, temperature, heart rate) of emotional experiences (basic and aesthetic emotions) influenced by the modal forms of Chinese traditional pentatonic modes and Western major and minor modes.ResultsFirstly, the arousal level of music emotion is a primary factor influencing individuals’ aesthetic emotional experiences in music, which is related to the intensity of modal construction in music; Secondly, the emotional pleasure and skin temperature change induced by pentatonic music are greater than those induced by major and minor modes; Thirdly, the arousal level, electrodermal change, and heart rate variability of major and minor modes are greater than those of pentatonic music; Finally, music training experience enhances college students’ familiarity and preference for pentatonic music, thereby strengthening the electrodermal physiological indicators of emotional experiences.ConclusionThe different modal forms of music express different levels of emotional arousal, leading to differences in individuals’ emotional dimensions and physiological indicators in music. Additionally, individuals’ music training experiences and cultural backgrounds also influence their experience of music emotions.
Experience of CBT in adults with ADHD: a mixed methods study
Authors: William Sandy , Horrocks Matthew , Richmond Jemma , Hall Charlotte L. , French Blandine 
Published: June 2024

IntroductionThe National Institute for Health and Care Excellence (NICE) recommends Cognitive-Behavioural therapy (CBT) as the psychotherapeutic treatment of choice for adults with Attention Deficit Hyperactivity Disorder (ADHD) in the UK. However, the literature often refers to adapted CBT programs tailored for ADHD and provides limited insight into how adults with ADHD experience and perceive this form of treatment in routine clinical practice.MethodsThis mixed-methods study aims to explore ADHD individuals’ experience and perception of CBT delivered in routine clinical practice, to gain a better understanding of this treatment’s helpfulness and perceived effectiveness.ResultsA survey (n=46) and semi-structured in-depth interviews (n=10) were conducted to explore the experience of CBT and its perceived effectiveness in managing ADHD. The interviews were analysed using thematic analysis and the survey was synthesised using descriptive narratives. The thematic analysis highlighted three key themes: difficulties with the CBT framework, difficulties with CBT therapists, and consequences of CBT. The survey highlighted similar findings. Participants described the CBT framework as, generic, rigid, and too short, and described the CBT therapist as unspecialised, unempathetic, and not sufficiently adapting CBT to ADHD-related difficulties.DiscussionsOverall, participants found non-adapted, generic CBT in the UK to be unhelpful, overwhelming, and at times harmful to their mental well-being. Therefore, it is necessary for clinical bodies in the UK, while following the indicated NICE guidelines, to be mindful of adapting CBT delivery of CBT, to be most effective for people with ADHD and to mitigate potential harm.
Anxiety among children a year after the onset of the COVID-19 pandemic: a Brazilian cross-sectional online survey
Authors: Garcia de Avila Marla Andréia , de Jesus Amorin Tainara , Hamamoto Filho Pedro Tadao , de Almeida Graziela Maria Ferraz , Olaya-Contreras Patricia , Berghammer Malin , Jenholt Nolbris Margaretha , Nilsson Stefan 
Published: June 2024

AimThis study seeks to build upon a prior investigation into the impact of the COVID-19 pandemic and to evaluate the prevalence of anxiety among Brazilian children, along with its associated factors, one year after the commencement of the pandemic.DesignA cross-sectional study.MethodsA survey was conducted from April–May 2021 in Brazil. Children aged 6–12 and their guardians from five Brazilian regions were included. The Children’s Anxiety Questionnaire (CAQ; scores 4–12) and Numerical Rating Scale (NRS; scores 0–10) were used to measure anxiety.ResultsOf the 906 children, 53.3% were girls (average age = 8.79 ± 2.05 years). Mothers responded for 87.1% of the children, and 70.9% were from the Southeast region. Based on a CAQ score of ≥9 and an NRS score of ≥8, the anxiety prevalence was 24.9 and 34.9%, respectively. Using logistic regression, a CAQ ≥9 score was associated with older children and children with chronic disease or disability. An NRS score of ≥8 was associated with reduced family income during the pandemic, the person caring for the children, and with children with chronic disease or disability.ConclusionThese findings suggest the need to implement public health actions aimed at children with chronic diseases and disabilities and their parents to guide them regarding the warning signs and negative emotions. This study contributes to characterizing the evolution of the pandemic in Brazil and provides a basis for comparison with the literature from other countries.
Health beliefs of unmarried adult Saudi individuals toward safe marriage and the role of premarital screening in avoiding consanguinity: a nationwide cross-sectional study
Authors: Alwhaibi Reem M. , Almuwais Afrah K. , Alotaibi Madawi , AlTaleb Hanan M. , Alsamiri Shatha M. , Khan Ruqaiyah 
Published: June 2024

IntroductionPremarital screening (PMS) is an essential global measure that seeks to reduce the occurrence of specific genetic disorders and sexually transmitted diseases common in consanguineous marriages. Due to the lack of a nationwide study, this research was designed to comprehend how unmarried individuals perceive the risks and benefits of PMS.MethodA cross-sectional study was conducted using an online questionnaire distributed through different social media platforms, responses from the native adult population (18–49 years) Saudi Arabia was only included in the study. The questionnaire was based on the Health Belief Model (HBM) to assessing seven different constructs including susceptibility, seriousness, benefits-, barriers-, &amp; cues- to action, self-efficacy, and social acceptance. Data frequency was represented by mean and standard deviation; chi-square and t-tests were conducted for the comparison of independent and dependent variables. A multinomial logistic regression was used to predict factors influencing decisions related to PMS.Results1,522 participants completed the survey, mostly 18–25 years old and most of them were women. The majority were single with 85 men and 1,370 women. Most participants (59.6%) believed their parents were related, while 40.5% did not. 122 respondents reported they had to marry within their tribe. Findings revealed significant correlations among all HBM themes, with varying strengths. Notably, a moderate positive relationship was found between the perception of benefits and cues to action, suggesting that enhancing the perceived benefits of PMS could facilitate safe marriage practices. Multinomial regression analysis revealed that demographic factors and health beliefs significantly influence individuals’ intentions and behaviors toward PMS and safe marriage.ConclusionThe study concludes that by identifying and addressing barriers, and promoting positive social acceptance, PMS can significantly contribute to preventing genetic diseases and promoting safe marriage practices, although the cross-sectional design limits the establishment of causal relationships and further research is needed.
Perspectives of people with spinal cord injury on a pain education resource
Authors: Fernandez Gabriel E. , Anderson Kim D. , Vastano Roberta , Frank Scott I. , Robayo Linda E. , Cherup Nicholas P. , Kochen William , Widerström-Noga Eva 
Published: June 2024

IntroductionSpinal cord injury (SCI) often leads to neuropathic pain that negatively affects quality of life. Several qualitative research studies in individuals with SCI who experience neuropathic pain indicate the lack of adequate information about pain. We previously developed an educational resource, the SeePain, based on scientific literature and a series of qualitative interviews of people with SCI, their significant others/family members, and SCI healthcare providers.MethodsHowever, to quantitatively evaluate the utility of this educational resource in a larger sample, we examined the agreement and usefulness ratings of statements regarding clarity/comprehensibility, content, and format of the SeePain, derived from the thematic analysis of our previous qualitative interviews. Participants completed a survey that provided a digital version of the SeePain and then rated their agreement/usefulness with the statements using numerical rating scales.ResultsThere were overall high perceived agreement and usefulness ratings regarding the SeePain’s clarity, content, and format. A factor analysis reduced the agreement and usefulness ratings into 4 components (content, clarity, format, and delivery medium). Group comparisons showed that individuals with higher education were more likely to endorse electronic and website formats, and the usefulness of a shorter version of the SeePain; females and younger individuals showed greater endorsement for clarity. Finally, higher pain intensity ratings were associated with greater agreement and usefulness of the content of the SeePain.DiscussionOverall, these results support the utility of the SeePain as a source of information regarding pain that may facilitate communication about pain and its management following SCI.
Association of results of the glutaraldehyde coagulation test with plasma acute phase protein concentrations and hematologic findings in hospitalized cows
Authors: Trefz Florian M. , Balmer Martina , Peters Laureen M. , Bruckmaier Rupert M. , Meylan Mireille 
Published: June 2024

IntroductionThe glutaraldehyde test (GAT) allows for animal-side semi-quantitative estimation of fibrinogen and gamma-globulin concentrations in blood samples of adult cattle and therefore detection of inflammatory disease conditions. However, the test has potential limitations, especially due to the latency period until sufficiently high fibrinogen and/or gamma-globulin concentrations are reached. The aim of the present study was therefore to assess the association between results of GAT with other inflammatory markers including hematologic variables, fibrinogen, plasma haptoglobin and serum amyloid A (SAA) concentrations.MethodsFor the purpose of this prospective observational study, a convenience sample of 202 cows with a broad range of inflammatory and non-inflammatory clinical conditions was included. The GAT was run on EDTA blood, fibrinogen was measured using the Clauss and the heat precipitation method, and commercially available ELISA tests were used for determination of plasma haptoglobin and SAA concentrations.ResultsShortened GAT coagulation times were more closely correlated to serum globulin (rs = −0.72) than to plasma fibrinogen concentrations measured with the heat precipitation (rs = −0.64) and the Clauss method (rs = −0.70). Cows with a markedly (≤3 min) or moderately (4–6 min) shortened coagulation time had higher (p &lt; 0.001) plasma haptoglobin and SAA concentrations than cows with a negative test result. Total leukocyte, monocyte and neutrophil concentrations did not differ significantly between groups. An identified cut-off for the GAT coagulation time of ≤14 min had a sensitivity and specificity of 54.4 and 100%, respectively, for the prediction of an inflammatory state based on clinical findings and/or increased plasma haptoglobin or SAA concentrations.DiscussionIn conclusion, this study demonstrates considerable diagnostic agreement between positive GAT results and increased plasma concentrations of haptoglobin and SAA. Despite high specificity, the test lacks sensitivity in case of acute inflammatory conditions indicating that plasma acute phase protein concentrations and hematologic findings can provide additional diagnostic information if the GAT is negative.
ظاهرة التَّعْجيبُ الأرسطيّ عند حازِم القرطاجنيّ في كتابه "منهاج البلغاء"
Authors: الياسين محمد 
Published: June 2024

تتناول هذه الورقة مفهومَ التعجيب في كتب النقد الأدبيّ والفلسفيّ منذ الإشارة إليه في مؤلَّف "فنّ الشعر" لأرسطوطاليس إلى أن وصلَ إلى حازم القرطاجنيّ، مروراً بالفلاسفة والمترجمين العرب كابن سينا وابن رشد؛ مع التركيز على جهود القرطاجنيّ في هذا المجال في كتابه "منهاج البلغاء" الذي يُستشَفّ منه المعنى الحقيقي للتعجيب كما فهمه القرطاجنيّ، وارتباطه بالقضايا الشعرية التي كانت تشغل النقد القديم مثل المحاكاة والتخييل، والصدق والكذب، والوزن والإيقاع...
ويهدف البحث إلى إبراز دور القرطاجني في تطوير مفهوم التعجيب بالاعتماد على ما توافر له من مصادر وآراء فلسفيةٍ تعالج مسألتي الفنّ والشعر، مستعيناً بملكته النقدية الفذّة لتطبيقها على الشعر العربي.
وانطلق الباحث من عدة تساؤلاتٍ حاول أن يجيب عنها بطريقةٍ علميةٍ ممنهجة، من مثل: ما هو التعجيب؟ وكيف تناوله النقد الأرسطيّ؟ وكيف ساهم سوءُ الترجمة في ابتعاد التصوّر الفلسفيّ العربيّ عن نظيره اليونانيّ؟ وما تأثير تناقلِ الفلاسفة العرب لذلك التصوّر في حدوث الأخطاء التي وقعوا فيها عند تطبيقه على الشعر العربي؟ وفيما إذا كان القرطاجني قد استثمر مفهومَ التعجيب بطريقةٍ مختلفةٍ بناءً على تلك التصوّرات في كتابه "منهاج البلغاء"؟
واتخذ الباحث من المنهج الوصفيّ التحليليّ وسيلةً لبيان تأثر القرطاجنيّ بمن سبقه من الفلاسفة والنقاد فيما يخصّ مسألة التعجيب، أو القدرة على إحداث الدهشة لدى المتلقي، وذلك باللجوء إلى مراجعة النصوص النقدية الخاصة بالتعجيب بدءاً من كتاب "فنّ الشعر" لأرسطو، مروراً بالترجمات العربية القديمة والحديثة، والاطلاع على آراء الفلاسفة والنقاد العرب فيها؛ وصولاً إلى كتاب "منهاج البلغاء" لحازم القرطاجني، الذي شكّل نواة هذا البحث ومرجعه الأساسيّ.
وقد خلص البحث إلى أنّ مفهوم التعجيب ذي الأصلٍ الأرسطيٍّ مرَّ بتغيّراتٍ معنويةٍ مختلفةٍ تبعاً للترجمات العربية لكتاب "فنّ الشعر" ووفقاً لفَهْم كلّ ناقدٍ لمسألة التعجيب المذكورة، وأنّ مفهوم التعجيب لدى القرطاجنيّ اندمجَ بمكونات القصيدة وعناصرها الفنية والشكلية، كما اقترنَ بحالتي التأويل والتلقي وتقاطعَ مع كثيرٍ من المصطلحات الشعرية الحديثة في ذلك المجال.