bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract B21: Depression and quality of life in breast cancer survivors: 6–13 years postchemotherapy
Authors: ReyesGibby Cielito C. , Anderson Karen , Morrow P.K. , Buzdar Aman , Shete Sanjay , Hassan Sohela 
Published: May 2012

Abstract
Background: Advances in breast cancer treatment have markedly prolonged survival time. This study examines the prevalence of and risk factors for depression and its impact on quality of life in breast cancer patients 6–13 years post-treatment.
Method: The Patient Health Questionnaire (PHQ-8) and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 were mailed to assess depression and quality of life, respectively, in breast cancer patients who participated in clinical trials for paclitaxel chemotherapy treatment between 1994 and 2001.
Results: Two hundred forty patients participated (56% response rate). The years since treatment were between 6–13 years (mean= 7.9 and median=8). The mean score on the PHQ-8 scale was 4 points (SD=4.8; median=2.0) which decreased by years since treatment (Kruskal-Wallis, p&lt; 0.001). Prevalence of depression (PHQ score ≥10) was 16%. Reports of depression decreased every year from treatment by as much as 30%. Depression had a negative impact on quality of life measures (function, symptoms, financial and global health), irrespective of years from treatment. Logistic regression showed that younger age (OR age in years= 0.92; 95% Confidence Interval [C.I.] = 0.86, 0.99; p&lt;0.02), rheumatoid arthritis (OR=8.4; 95%C.I.=1.3–57.4; p&lt;0.03) and years from treatment (OR=0.70; 95% C.I.=0.46–0.99; p&lt;0.05) were significant predictors of depression.
Conclusion: While reports of depression decreased over the survival period, it remains a significant health concern for breast cancer survivors. The results suggest the need to monitor patients and provide resources for monitoring and treatment of depression within the clinical oncology setting.
Citation Information: Cancer Prev Res 2010;3(1 Suppl):B21.
Abstract B23: Evaluating an intervention to improve perceptions of cancer clinical trials among minority communities in South Carolina
Authors: Ford Marvella E. , Wahlquist Amy E. , Blake Rashell , Streets June , Johnson Erica , Sweat Melanie A. , Johnson Shannon , Garrett-Mayer Elizabeth 
Published: May 2012

Abstract
Objective: Cancer mortality rates for African Americans in South Carolina are among the highest in the nation. However, African Americans are less likely than other groups to participate in cancer clinical trials. Results of previous investigations have shown that their low participation rates are related to negative perceptions of trials. We conducted a community based cancer clinical trials education intervention to improve perceptions of cancer clinical trials in this population.
Methods: The study was conducted at eight different sites in six counties in South Carolina. The intervention consisted of a 30-minute cancer clinical trials educational presentation developed by the National Institutes of Health/National Cancer Institute. The intervention was part of a larger 3.5-hour education program aimed at increasing general cancer knowledge, prostate cancer knowledge, and perceived self efficacy in patient-physician interaction among minority populations in South Carolina. Study participants were recruited by community partners in each locale where the training sessions were conducted. A pre- and post-intervention survey was administered immediately before and after the intervention was delivered at each site. The survey instrument included seven items. Sample items include the following: Do you think that patients should be asked to take part in medical research? Would you be prepared to take part in a study comparing different treatments? Would you be prepared to take part in a study where treatment was chosen at random?
Results: The study sample consisted of 164 predominantly African American participants. One-hundred and twenty-five (78.6%) of the 159 participants who provided data on race were African American, 19 (12.0%) were Caucasian and 15 (9.4%) were Native American. The majority of the 160 participants who provided data on age were ages 50+ years (62.5%). The majority of the 154 participants who reported their income had an annual household income &gt; = $40,000 (53.8%). For each of the seven survey items assessing perceptions of cancer clinical trials, 74%, 69%, 56%, 49%, 61%, 50% and 58% of the participants, respectively, changed to more favorable responses on the post-test vs. pre-test. All results were statistically significant at the p&lt;0.001 level.
Conclusions: Providing cancer clinical trials information to African American community members positively influenced their trial perceptions. Future research could incorporate a longer follow-up assessment period.
Citation Information: Cancer Prev Res 2010;3(1 Suppl):B23.
Abstract B24: Evaluating an intervention to increase cancer knowledge in minority communities in South Carolina
Authors: Ford Marvella E. , Wahlquist Amy E. , Ridgeway Celina , Streets June , Mitchum Katherine A. , Harper Remus , Hamilton Ian , Etheredge Jim , Sweat Melanie A. , Garrett-Mayer Elizabeth 
Published: May 2012

Abstract
Objective: Cancer mortality rates for African Americans in South Carolina are among the highest in the nation. Lack of knowledge likely contributes to cancer disparities. To address this issue, we conducted a community based cancer education intervention to improve cancer knowledge among African American and other minority communities in South Carolina.
Methods: The study was conducted at eight different sites in six counties in South Carolina. The intervention consisted of a 3.5-hour evidence-based cancer education program in which a 3-hour component focused on general cancer knowledge and a 30-minute component focused on prostate cancer knowledge. Pre- and post-intervention surveys were administered immediately before and after the intervention was delivered at each site. The maximum score for the 31-item cancer knowledge instrument was 31. Prostate cancer knowledge was assessed using a 10-item instrument, with a maximum score of 10. Perceived self-efficacy in patient-physician communication about cancer was measured by a 5-item scale with a maximum score of 5. We hypothesized that the intervention would result in increases in general cancer knowledge, prostate cancer knowledge, and perceived self-efficacy in patient-physician interaction.
Results: The study sample consisted of 164 predominantly African American participants. One-hundred and twenty-five (78.6%) of the 159 participants who provided data on race were African American, 19 (12.0%) were Caucasian and 15 (9.4%) were Native American. The majority of the 160 participants who provided data on age were ages 50+ years (62.5%). The majority of the 154 participants who reported their income had an annual household income &gt; = $40,000 (53.8%). The general cancer knowledge pre-test score had a mean of 26.2 with a standard deviation (SD) of 3.7 and a mean post-intervention increase of 2.04 points (p&lt;0.01). The mean pre-test prostate cancer knowledge score was 7.3 (SD 2.0). The mean increase in prostate cancer knowledge was 0.48 points (p&lt;0.01). Due to a ceiling effect, most sites showed little increase in perceived self-efficacy in patient-physician interaction (PEPPI). The exception was the Native American site, which had a larger increase in each PEPPI question from pre-test to post-test than the other sites.
Conclusions: General cancer knowledge scores and prostate cancer knowledge scores increased following the intervention. Future interventions could incorporate more intensive (i.e., repeated sessions) cancer education programs as well as an assessment of the impact of the interventions on the communication dynamics between patients and their health care providers.
Citation Information: Cancer Prev Res 2010;3(1 Suppl):B24.
Abstract B25: Feelings associated with research participation influence willingness to take part in epidemiological studies
Authors: Kiviniemi Marc T. , Erwin Deborah O. , Moysich Kirsten , Walker Charles , Davis Warren , Ciupak Greg , Clark-Hargrave Nikia , Congi Kim , Cohen Emily , Primus Alexandra , Posey Patrick , Hallman Elizabeth 
Published: May 2012

Abstract
Purpose: Cancer epidemiology research often involves members of the public as “healthy controls.” Encouraging broad participation in cancer research is a key concern, particularly for research involving members of the general public who may have lower motivation to take part. Most work of individuals' decisions about study participation has focused on expected utility constructs, examining the benefits participants see to participating and the barriers that make participation less likely. Little attention has been paid to emotional decision-making processes in this context. Such emotional processes (e.g., fear about procedures, anger about historical research misconduct) may guide decisions about participation. The purpose of this study was to examine the relation of cognitive and affective decision-making factors to individuals' participation in a epidemiologic study involving both questionnaire completion and blood collection.
Method: Participants (N=46) were community adults in Niagara Falls, NY who were taking part in an educational program about cancer-related research participation. Both prior to and following the educational program, we assessed participants' beliefs about the expected utility of participating in studies that involve questionnaire completion and studies that involve blood collection, the positive and negative feelings they associated with taking part in each type of study, and their willingness to take part in each type of study. Following the post-program questionnaire, participants were offered the opportunity to take part in an epidemiological study in which they could complete a questionnaire, provide a blood sample, or do both.
Results: Both willingness to participate in studies and actual participation was primarily predicted by the feelings individuals associated with research, for both blood draw studies and questionnaire studies, those with more negative feelings about participation were less like to report willingness to take part in the study; questionnaire willingness B=−1.21, p&lt;.05; blood willingness B=−0.97, p&lt;.05. For blood draw studies, affective associations also predicted actual participation; B=−1.15, p&lt;.05.
Discussion: The feelings individuals have about research participation played a central role in determining participation. Both research to better understand determinants of research participation and interventions to increase participation should consider affective factors.
Citation Information: Cancer Prev Res 2010;3(1 Suppl):B25.
Abstract B27: Social representations of human papillomavirus (HPV) in Bogotá, Colombia: A qualitative study
Authors: Wiesner Carolina , Acosta Jesús , Díaz del Castillo Adriana , Tovar-Murillo Sandra L. , Salcedo-Fidalgo Hernando 
Published: May 2012

Abstract
Introduction: Identifying DNA of Human papillomavirus (HPV) among asymptomatic women has been proposed as a new screening method for cervical cancer control. Screening programs must be preceded by health education. Traditionally, health education is based on scientific information without considering any community cognitive processes. This paper studies HPV social representations constructed upon social interaction between men and women over 25 years of age, living in Bogotá, Colombia. The outcomes will be used as groundwork for an education strategy to promote HPV testing within a primary screening program.
Methods: It is a qualitative study based upon symbolic interaccionism. Inter individual communication is precisely the ground where a framework of references is constructed and social representations emerge. Focus group selection was planned using a theoretical population sample. Twelve focus groups were held with 124 men and women from diverse educational status. Information source analysis and graphic analysis of significants were performed.
Results: Social representation of HPV involves a series of figurative nuclei that arose from associated meanings linked to scientific information. While women focused on symbols associated to contagion; men focused on its venereal character. Negative feelings were expressed particularly among women with a history of one sexual partner. Figurative nuclei also included long-term uncertainty, need or urgent treatment and feelings of imminent death that are associated to cancer and chronic sexually transmitted infections. The social representation burden of HPV impeded many participants from clearly understanding written information about HPV transmission, clearance and cancer risk.
Conclusion: HPV social representations are built into a whole framework of values, which must be deconstructed to allow women full participation in HPV screening programs and to prevent psychosocial adverse effects. Delivering scientific information may not be enough for achieving this purpose. Shared decision making is a communication strategy that must be promoted for anticipatory discussion on HPV-DNA testing to be able to deconstruct different values and meanings particularly its association with promiscuity and venereal diseases.
Citation Information: Cancer Prev Res 2010;3(1 Suppl):B27.
Abstract B3: Effect of consuming pistachios on the intake and serum levels of γ-tocopherol
Authors: Hernandez Ladia M. , Forman Michele R. , Radcliffe John D. 
Published: May 2012

Abstract
Pistachios are one of the best dietary sources of gamma-tocopherol (γ-T), a form of vitamin E that may help to protect against certain forms of cancer, such as lung among high risk groups like smokers. We investigated the effect of the incorporation of pistachios (at a level of 68 g per day) on the intakes and serum cholesterol-adjusted γ-T (micromole/millimole) using a six-week randomized, controlled, clinical trial design, having a two-week preintervention period and a four-week intervention period. Participants (n = 36) were healthy males and females, randomized to either the control group or the intervention group. Intakes were calculated using the Nutrition Data System for Research Version 2007. Diet diaries and weights of returned pistachios were reviewed to assess consumption. Weekly compliance for pistachio consumption ranged between 88-93%. No statistically significant treatment differences were observed for BMI, total energy or percent energy from protein. On the pistachio diet (PD), statistically significant increases were seen for percent energy from fat at weeks 3 and 4 and weeks 5 and 6 compared to weeks 1 and 2. Additionally, on the PD, a statistically significant increase for percent energy from fat was seen at weeks 5 and 6 compared to the control diet (CD). On the PD, statistically significant decreases were seen for percent energy from carbohydrate at weeks 3 and 4, and weeks 5 and 6 compared to weeks 1 and 2. Additionally, on the PD, a statistically significant decrease for percent energy from carbohydrate was seen at weeks 5 and 6 compared to the CD. On the PD, statistically significant increases were seen in energy-adjusted dietary γ-T at weeks 3 and 4 compared to weeks 1 and 2 (mean difference of 26%; p &lt; 0.001), weeks 5 and 6 compared to weeks 1 and 2 (mean difference of 27%; p &lt; 0.001). Additionally, statistically significant increases in energy-adjusted dietary γ-T were seen at weeks 3 and 4 on the PD compared to the CD (mean difference of 21%; p &lt; 0.001) and at weeks 5 and 6 on the PD compared to the CD (mean difference of 24%; p &lt; 0.001). On the PD, a statistically significant increase was observed for post intervention cholesterol-adjusted serum γ-T (mean difference of 26%; p &lt; 0.001) compared to pre-intervention value. For the intervention group, a Pearson correlation was calculated for the change in energy-adjusted γ-T intake between weeks 1 and 2 and weeks 5 and 6 and the change in cholesterol-adjusted serum γ-T pre- and post intervention (r =.373; p =.025). Thus, consumption of pistachios can lead to an increase in serum levels of γ-T. Pistachios could be incorporated into dietary strategies designed to reduce the risk of lung cancer.
Citation Information: Cancer Prev Res 2010;3(1 Suppl):B3.
Abstract B33: Reducing the ethnic/minority cancer burden in communities in S.E. Michigan utilizing a community-based participatory process
Authors: Dykes Vicky A. , Akhtar Adil , Berry Stanley , Jaiyesimi Ishamael , Douglas-Nikitin Vonda , Rivers Aeisha , Shetty Sugandh , Vicini Frank A. , Fakhouri Monty 
Published: May 2012

Abstract
Purpose: We reviewed the impact of a community based participatory process (CBPP) addressing cancer education, prevention, and screening in five major ethnic/minority populations in Southeastern Michigan to determine their impact on personal health related decisions.
Materials and Methods: From 2003 to 2009, 2,988 community members participated in CBPP conducted by Beaumont Cancer Institute in collaboration with the Arab American and Chaldean Council, Michigan Association of Physicians from India, North American Indian Association, American Indian Health and Family Services, Mexican Consulate, Multicultural La Famila, National Cancer Institute, and American Cancer Society. The study population consisted of 1,253 (42%) individuals completing a post-cancer forum survey and/or obtaining some type of cancer screenings: 747 (59.6%) from African American, 425 (33.9%) from Arab American/Chaldean, 14 (1.1%) from Native American, 35 (2.8%) from South East Asian and 32 (2.6%) from Hispanic/Latino communities. Data were collected on behavioral intent and knowledge including: (1) forum content, (2) participants' cancer screening history, (3) symposium logistics (4) educational materials and (5) participation in subsequent cancer screening tests.
Results: After attending at least one cancer forum, 426 (34%) of 1,253 respondents (14.3 % of all attendees) underwent some type of cancer screening: 146 women (11.7%) underwent a screening mammogram, 94 (7.5%) a pap smear and 97 (7.7%) men underwent a screening PSA. A total of 89 (7.1%) had other forms of cancer screenings.
Conclusions: Results from this study suggest that CBPP's around a perceived and/or serious disease negatively affecting a target population can positively impact their personal health related decisions.
Citation Information: Cancer Prev Res 2010;3(1 Suppl):B33.
Abstract B39: Prostaglandin E2 induces human enhancer of filamentation 1 to promote the cell motility of colorectal carcinoma cells
Authors: Xia Dianren , Wang Dingzhi , Menter David G. , DuBois Raymond N. 
Published: May 2012

Abstract
PGE2 promotes cell motility during colorectal carcinogenesis. The mechanism by which PGE2 signaling regulates cell motility is not completely understood. Here, we demonstrated that PGE2 treatment induces HEF1 expression that links with cell motility in colorectal cancer cells. PGE2 rapidly stimulated HEF1 expression in colorectal cancer cells. Both PGE2 treatment and HEF1 overexpression activated Rac 1 and resulted in similar effects on cell spreading. Moreover, knockdown of HEF1 using shRNA suppressed PGE2-driven cell spreading. PKA activator forskolin induced HEF1 expression and cell spreading in a similar manner as PGE2. Inhibition of PKA activity by H-89 attenuated HEF1 expression induced by PGE2. Furthermore, PKA knockdown by siRNA blocked the HEF1 expression and cell spreading induced by PGE2. These data suggest that PGE2 induces HEF1 expression to promote cell motility through a PKA-involved pathway.
Citation Information: Cancer Prev Res 2010;3(1 Suppl):B39.
Abstract B42: Modulation of integrin-mediated cell adhesion by ADAM15 disintegrin-like domain
Authors: Lee Hee Doo , Park Michael Y. , Jeon Ok-Hee , Kim Doo-Sik 
Published: May 2012

Abstract
Integrin-mediated cell adhesion on extracellular matrix works essentially on numerous physiological processes such as cell adhesion, migration and angiogenesis. As integrin ανβ3 and integrin α5β1 are the representative receptors for cell adhesion and due to their important function in cancer biology, the antagonists targeting the integrins has been sought for long. Lately, the interactions between ADAM (A Disintegrin And Metalloprotenase) 15, the only member in ADAM family with Arg-Gly-Asp (RGD) motif, and the ανβ3 and α5β1 intergins was observed. For that, we experimented on the cellular function of recombinant ADAM15-derived disintegrin-like domain containing Asp-Typ-Lys-Arg-Gly-Asp (rNWKRGD) in integrin-mediated cell adhesion. The binding affinity of HUVEC, COS-1, MCF-7 and MDAH 2274 cells to various extracellular matrix proteins were increased by the disintegrin-like domain in a dose-dependent manner, and the presence of inhibitory integrin α5β1 antibody thoroughly abrogated the rNWKRGD-stimulated binding. By mutagenic analysis, it was founded that RGD motif is essential for the binding. In comparison, saxatilin, RGD disintegrin from snake venom, inhibited binding of cells to ECM proteins. Through flow cytometric analysis, we confirmed that β1 integrin on the cell surface was activated by rNWKGRD. All these results indicated that the activation of integrin α5β1 mediates the rNWKRGD-stimulated cell adhesion. Therefore rNWKRGD could function as the potential activator of cell migration and proliferation. Although disintegrin is known as inhibitor of cell migration and proliferation, it is possible that ADAM15 disintegrin domain could have a regulatory role in integrin function such as angiogenesis and invasion of cancer cells. (This work was supported by the Korea Science and Engineering Foundation (KOSEF) grant funded by the Korea government (No. 2009-0081759), KIST grant, and the Brain Korea 21 (BK21).)
Citation Information: Cancer Prev Res 2010;3(1 Suppl):B42.
Abstract B45: Identification of chromosome aberration of oral squamous cell carcinoma patients in southern India
Authors: Manikantan Pappuswamy , Balachandar Vellingiri , Sasikala Keshavarao , Mohanadevi S. , Lakshmankumar Balasubramanium , Velmurugan Palanivel , Prabudhas K. 
Published: May 2012

Abstract
Oral squamous cell carcinoma (OSCC) is the most frequent cancer and constitutes a major health problem in India, representing the leading cause of death. The aim of the present investigation was to study the major chromosomal aberrations (CA) like deletion, translocation, inversion and mosaic in OSCC patients of South India. Genetic factors play an important role in the etiology of OSCC. Totally 300 oral sumucosa fibrosis symptoms patients were chosen from various hospitals from southern india by advent screening like Toluidine blue staining and brush biopsy. Finally 103 severely affected OSCC patients were selected. 5ml of peripheral blood samples were taken from affected patients. Equal numbers of normal healthy control subjects were chosen after signing a consent form. Cytogenetic studies were performed by using Giemsa-banding technique and finally the results were ensured by spectral karyotyping (SKY) technique. In the present investigation, major CA like deletion, translocation, inversion and mosaic were identified in experimental subjects. Results showed frequent CA in chromosomes 3p, 3q, 8p, 7p, 9p, 11q, 17p, 19q and X. In comparison with experimental subjects, the control subjects exhibited very low levels of major CA (P&lt;0.05). In the present study, the high frequency of centromeric rearrangements indicates a potential role for mitotic irregularities associated with the centromere in OSCC tumorigenesis, interesting chromosomal regions which may harbor susceptibility genes. Identification of chromosome alterations may be helpful in understanding the molecular basis of the disease in a better manner.
Citation Information: Cancer Prev Res 2010;3(1 Suppl):B45.