bluuebunny/crossref_metadata_2025_split huggingface dataset:
NSAIDs for early management of acute respiratory infections
Authors: Bassetti Matteo , Andreoni Massimo , Santus Pierachille , Scaglione Francesco 
Published: May 2024

Purpose of review
To review the rationale for and the potential clinical benefits of an early approach to viral acute respiratory infections with NSAIDs to switch off the inflammatory cascade before the inflammatory process becomes complicated.

Recent findings
It has been shown that in COVID-19 as in other viral respiratory infections proinflammatory cytokines are produced, which are responsible of respiratory and systemic symptoms. There have been concerns that NSAIDs could increase susceptibility to SARS-CoV-2 infection or aggravate COVID-19. However, recent articles reviewing experimental research, observational clinical studies, randomized clinical trials, and meta-analyses conclude that there is no basis to limit the use of NSAIDs, which may instead represent effective self-care measures to control symptoms.

Summary
The inflammatory response plays a pivotal role in the early phase of acute respiratory tract infections (ARTIs); a correct diagnosis of the cause and a prompt therapeutic approach with NSAIDs may have the potential to control the pathophysiological mechanisms that can complicate the condition, while reducing symptoms to the benefit of the patient. A timely treatment with NSAIDs may limit the inappropriate use of other categories of drugs, such as antibiotics, which are useless when viral cause is confirmed and whose inappropriate use is responsible for the development of resistance.
Papillary Thyroid Cancer, Small Cell Lung Cancer, and Parathyroid Adenoma Synchronously Visualized on 99mTc-MIBI SPECT/CT in a Patient With Hyperparathyroidism
Authors: Chun In Kook , Lee Seungkoo 
Published: May 2024

Abstract

99mTc-MIBI scintigraphy is a nuclear medicine imaging modality commonly used for the preoperative localization of parathyroid adenomas in patients with hyperparathyroidism. In addition, 99mTc-MIBI can also be used for imaging various tumors due to its unique mechanism of intracellular accumulation. Here, we introduced a case of a single 99mTc-MIBI SPECT/CT simultaneously visualized two different malignant tumors, such as papillary thyroid cancer and small cell lung cancer, along with a parathyroid adenoma in a patient with hyperparathyroidism. The clinical usefulness of 99mTc-MIBI SPECT/CT was also explored by comparing it with 18F-FDG PET/CT among the three tumors.
Adult Neuroblastoma of the Neck Is Better Imaged With 18F-FDG PET/CT Than With 18F-DOPA PET/CT
Authors: Alabed Yazan Z. 
Published: May 2024

Abstract
A 41-year-old woman presented with 2 months history of right submandibular swelling. Biopsy revealed neuroblastoma (NB). Patient was referred for staging PET/CT scan. We compared the findings of 18F-DOPA PET/CT and 18F-FDG PET/CT scans. Both imaging modalities were positive in the patient; however, tumor delineation was superior with 18F-FDG PET/CT. Tumor uptake of FDG was significantly higher than tumor uptake of DOPA. Follow-up FDG PET/CT scan postsurgery showed local recurrent NB and their metastases avidly concentrate FDG. We present a very rare case of adult NB of the neck better imaged with FDG instead of DOPA PET/CT.
Does Time to Asystole in Donors After Circulatory Death Impact Recipient Outcome in Liver Transplantation?
Authors: Malik Abdullah K. , Tingle Samuel J. , Varghese Chris , Owen Ruth , Mahendran Balaji , Figueiredo Rodrigo , Amer Aimen O. , Currie Ian S. , White Steven A. , Manas Derek M. , Wilson Colin H. 
Published: May 2024

Background.
The agonal phase can vary following treatment withdrawal in donor after circulatory death (DCD). There is little evidence to support when procurement teams should stand down in relation to donor time to death (TTD). We assessed what impact TTD had on outcomes following DCD liver transplantation.

Methods.
Data were extracted from the UK Transplant Registry on DCD liver transplant recipients from 2006 to 2021. TTD was the time from withdrawal of life-sustaining treatment to asystole, and functional warm ischemia time was the time from donor systolic blood pressure and/or oxygen saturation falling below 50 mm Hg and 70%, respectively, to aortic perfusion. The primary endpoint was 1-y graft survival. Potential predictors were fitted into Cox proportional hazards models. Adjusted restricted cubic spline models were generated to further delineate the relationship between TTD and outcome.

Results.
One thousand five hundred fifty-eight recipients of a DCD liver graft were included. Median TTD in the entire cohort was 13 min (interquartile range, 9–17 min). Restricted cubic splines revealed that the risk of graft loss was significantly greater when TTD ≤14 min. After 14 min, there was no impact on graft loss. Prolonged hepatectomy time was significantly associated with graft loss (hazard ratio, 1.87; 95% confidence interval, 1.23-2.83; P = 0.003); however, functional warm ischemia time had no impact (hazard ratio, 1.00; 95% confidence interval, 0.44-2.27; P > 0.9).

Conclusions.
A very short TTD was associated with increased risk of graft loss, possibly because of such donors being more unstable and/or experiencing brain stem death as well as circulatory death. Expanding the stand down times may increase the utilization of donor livers without significantly impairing graft outcome.
Molecular mechanisms promoting long-term cytopenia after BCMA CAR-T therapy in Multiple Myeloma
Authors: Palacios-Berraquero Maria Luisa , Rodriguez-Marquez Paula , Calleja-Cervantes Maria Erendira , Berastegi Nerea , Zabaleta Aintzane , Burgos Leire , Alignani Diego , San Martin-Uriz Patxi , Vilas-Zornoza Amaia , Rodriguez-Diaz Saray , Inoges Susana , Lopez-Diaz de Cerio Ascensión , Huerga Sofia , Tamariz Esteban , Rifón Jose , Alfonso-Pierola Ana , Lasarte Juan Jose , Paiva Bruno , Hernaez Mikel , Rodriguez-Otero Paula , San Miguel Jesus , Ezponda Teresa , Rodriguez-Madoz Juan Roberto , Prosper Felipe 
Published: May 2024

ABSTRACTHematological toxicity is a common side effect of CAR-T therapies, being particularly severe in relapsed/refractory multiple myeloma (MM) patients. In this study, we analyzed a cohort of 48 patients treated with BCMA CAR-T cells to characterize the kinetics of cytopenia, identify predictive factors and determine potential mechanism underlying these toxicities. The overall incidence of cytopenia was 95.74%, and grade>3 thrombocytopenia and neutropenia one month after infusion was observed in 57% and 53% of the patients and was still present after 1 year in 4 and 3 patients respectively. Presence of cytopenia at baseline and high peak inflammatory markers highly correlated with cytopenia persisting up to three months. To determine potential mechanisms underpinning cytopenias, we evaluated the paracrine effect of BCMA CAR-T cells on the differentiation of HSPCs using anex-vivomyeloid differentiation model. Phenotypic analysis showed that supernatants from activated CAR-T cells (spCAR) halted HSPCs differentiation promoting more immature phenotypes, with reduced expression of granulocytic, monocytic and erythroid markers. Single-cell RNAseq demonstrated an upregulation of transcription factors associated with early stages of hematopoietic differentiation in the presence of spCAR (GATA2, RUNX1andCEBPA)and decreased activity of key regulons involved in neutrophil and monocytic maturation (ID2andMAFB). Our results suggest that CAR-T cell activation negatively influences hematopoietic differentiation through paracrine effects inducing arrest of HSPCs maturation and contributes to the understanding of severe cytopenia observed after CAR-T cell treatment in MM patients. These results may identify regulatory mechanisms involved in alter hematopoiesis and could lead to alternative therapeutic strategies.KEY POINTSLong-lasting cytopenia after BCMA CAR-T therapy correlates with baseline cytopenia and peak inflammatory markers.Supernatants from activated BCMA CAR-T cells induced an inhibition of ex-vivo myeloid differentiation and rewiring of transcriptional programs associated with hematopoietic differentiation.
An anti-SARS-CoV-2 formula consisting volatile oil from TCM through inhibiting multiple targets in cultured cells
Authors: Zhang Huan , Guo Wuyan , Shen Jing , Song Xiaorui , Zhang Bo 
Published: May 2024

AbstractAt present, coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variant virus are prevalent all over the world, taking a major toll on human lives worldwide. Oral mucosa and saliva are the high-risk routes of transmission. Inactivation of the virus in the mouth is one of the important strategies to reduce the source infectivity of the virus. However, the current preparations for inactivating oral virus are mainly aimed at ACE2 protein, and its effect needs to be improved. In this study, through literature mining, multi-target screening and other methods, we screened and optimized the volatile oil formula (Artemisiae argyi folium, Chrysanthemum morifolium, Trollii chinensis flos, Lonicerae japonicae flos) from the volatile oil of traditional Chinese medicine to inhibit the invasion and replication of SARS-CoV-2. A test using pseudotype virus with S glycoprotein confirmed that this formula could effectively bind to the S glycoprotein to prevent SARS-CoV-2 host cell entry. Molecular docking experiments showed that the m ultiple molecules in the formula might weakly bind to these targets including ACE2, cathepsin L, furin, mpro/3cl. In all, the volatile oil formula designed in this paper offers a general affordable strategy to protect patients from SARS-CoV-2 infections through debulking or minimizing transmission to others.
Development of fluoro-7-aminocarboxycoumarin-based mitochondrial pyruvate carrier inhibitors as anticancer agents
Authors: Schumacher Tanner J. , Gardner Zachary S. , Rumbley Jon , Ronayne Conor T. , Mereddy Venkatram R. 
Published: May 2024

ABSTRACTReprogrammed metabolism of cancer cells offers a unique target for pharmacological intervention. In the current study, a series of novel and potentially metabolically stable fluoro-substituted aminocarboxycoumarin derivatives are evaluated for their mitochondrial pyruvate carrier (MPC) inhibition properties. Our studies indicate that the aminocarboxycoumarin template elicits potent MPC inhibitory characteristics, and specifically, structure activity relationship studies show that theN-methyl-N-benzyl structural template provides the optimal inhibitory capacity. Further respiratory experiments demonstrate that candidate compounds specifically inhibit pyruvate driven respiration without substantially affecting other metabolic fuels consistent with MPC inhibition. Further, computational homology and inhibitor docking studies illustrate that aminocarboxycoumarin binding characteristics are indicative of reversible covalent bonding with amino acids in the pyruvate binding domain. Epifluorescent microscopy experiments illustrated that FACC2 accumulates in the mitochondria to a similar extent as parent 7ACC2. Additionally, lead candidate aminocarboxycoumarin derivative D7 elicits cancer cell proliferation inhibition specifically in monocarboxylate transporter 1 (MCT1) expressing 4T1, consistent with its ability to accumulate intracellular lactate.In vivotumor growth studies illustrate that D7 significantly reduces the tumor burden in two isogeneic murine cell lines 4T1 and 67nr. These studies provide novel MPC inhibitors with potential for anticancer applications.
Predicting Future Kinetic States of Physicochemical Systems Using Generative Pre-trained Transformer
Authors: Bera Palash , Mondal Jagannath 
Published: May 2024

AbstractCapturing the time evolution and predicting future kinetic states of physicochemical systems present significant challenges due to the precision and computational effort required. In this study, we demonstrate that the transformer, a machine learning model renowned for machine translation and natural language processing, can be effectively adapted to predict the dynamical state-to-state transition kinetics of biologically relevant physicochemical systems. Specifically, by using sequences of time-discretized states from Molecular Dynamics (MD) simulation trajectories as input, we show that a transformer can learn the complex syntactic and semantic relationships within the trajectory. This enables this generative pre-trained transformer (GPT) to predict kinetically accurate sequences of future states for a diverse set of models and biomolecules of varying complexity. Remarkably, the GPT can predict future states much faster than traditional MD simulations. We show that it is particularly adept at forecasting the time evolution of an out-of-equilibrium active system that do not maintain detailed balance. An analysis of self-attention mechanism inherent in transformers is found to hold crucial role for capturing the long-range correlations necessary for accurate state-to-state transition predictions. Together, our results highlight the ability of transformer based machine learning model in generating future states of physicochemical systems with statistical precision.
The effect of CSR and corporate ethical behavior on implicit cost of equity: the mediating role of integrated reporting quality
Authors: Chouaibi Yamina , Khlifi Sawssen , Chouaibi Jamel , Zouari-Hadiji Rim 
Published: May 2024

Purpose
The purpose of this study is to analyze the effect of corporate social responsibility (CSR) practices and corporate ethical behavior on implicit cost of equity (COE) using integrated reporting quality (IRQ) as a mediating variable in European companies belonging to the environmental, social and governance (ESG) index.

Design/methodology/approach
The authors use a panel data set of 540 European firms from the ESG index from 2013 to 2022. The data were collected from I/B/E/S and Thomson Reuters ASSET4 database and analyzed using the structural equation model to test hypotheses.

Findings
In the instance of ESG European firms, the findings indicate that CSR practices and corporate ethical behavior are negatively related to the COE. From the result of the Sobel test, this study indicated that IRQ has only indirect mediation on the relationship between CSR, ethical behavior of the company and implicit COE.

Practical implications
The findings have some policy and practical implications that may help regulators and managers in improving the COE and helping companies envision their future growth opportunities in a context where responsibility, ethics and disclosure are central to corporate valuation. Using the implicit COE is a better estimate of shareholder requirements in the context of ESG companies.

Originality/value
This research concentrates on ESG companies since they are more likely to contribute to environmental protection, which attracts responsible investors. Furthermore, the findings may be useful to worldwide managers and investors who use responsible practices as a criterion in their decision-making.
Modelling enablers of business continuity for casual dining restaurants in post-COVID-19 era: an ISM and MICMAC perspective
Authors: Mandal Santanu , Dubey Ritesh Kumar , Basu Bhaskar , Raman Raghu 
Published: May 2024

PurposeWhile the COVID-19 pandemic has given many firms the importance of business continuity, restaurants have yet to realize the essential enablers. In this regard, the study explored the potential enablers that can help firms attain business continuity in the post-COVID-19 era for casual dining restaurants.Design/methodology/approachThis study used an extensive literature review and further supported 28 restaurant managers with an average experience of 8.5 years to identify the potential enablers for ensuring business continuity for casual dining restaurants. Subsequently, this study used the interpretive structural modelling coupled with Matrice d'Impacts Croisés Multiplication Appliquée à un Classement (MICMAC) analysis to understand the context-specific inter-relationships as a hierarchical structural model.FindingsFindings suggest that financial capability forms the key driver for other enablers in the hierarchy of business continuity for casual dining restaurants. Furthermore, manpower (local and outstation) are the second-level drivers of restaurant process control, digital presence, online reviews and feedback management, scalability, food quality, food delivery management, employee safety and hygiene. The third-level factors further help restaurants to achieve the dynamic capability required to provide customer value and ensure business continuity.Originality/valueThe study is the foremost to explore a business continuity framework in the new normal for casual dining restaurants in the country. Furthermore, several contextual inter-relationships exhibiting the hierarchy are also established for the business continuity of restaurants in the new normal.
Effect of multiple laser peening on the wear resistance of 304 stainless steel
Authors: Li Min , Liu Hangxuan , Zhang Xingquan , Yang Hengji , Zuo Lisheng , Wang Ziyu , Duan Shiwei , Shu Song 
Published: May 2024

Purpose
The purpose of this paper is to investigate the effect of laser peening (LP) on mechanical and wear properties of 304 stainless steel sheet.

Design/methodology/approach
Three-dimensional morphology, micro-hardness and micro-structure of shocked samples were tested. The wear amount, wear track morphology and wear mechanism were also characterized under dry sliding wear using Al2O3 ceramics ball.

Findings
The LP treatment generates deformation twins that contribute to the grain refinement and hardness increase. The wear test displays that the wear mechanism of samples is mainly abrasive wear and oxidation wear at 10 N load. While at 30 N, the delamination and adhesion areas of treated sample are reduced visibly compared to untreated ones.

Originality/value
This study specifically investigates the mechanical and wear properties of 304 stainless steel after the direct action of LP on its surface, which shows an effective improvement on the wear resistance. For example, the wear loss of processed sample is reduced by 19% at 30 N, the friction coefficient decreases from 0.4714 to 0.4308 and the groove depth is reduced from 78.1 to 74.4 µm under same condition.

Peer review
The peer review history for this article is available at: https://publons.com/publon/10.1108/ILT-01-2024-0007/
Exploring the internationalization pathways of luxury SMEs: is there an asset of foreignness?
Authors: Milanesi Matilde , Runfola Andrea , Guercini Simone 
Published: May 2024

PurposeThe paper delves into the international expansion of luxury SMEs to investigate their internationalization pathways, namely how the internationalization process unfolds in terms of timing of entry into foreign markets, the geographic scope of operations and the scale. The paper examines also the determinants of the internationalization pathways as a set of factors that contribute to developing an asset of foreignness.Design/methodology/approachThe paper adopts a multiple case study approach and reports findings from four cases of Italian SMEs operating in the luxury fashion industry.FindingsSMEs’ specific characteristics at the firm and entrepreneurial levels (i.e. craftsmanship, quality, product creativity, entrepreneurial mindset), country of origin attributes (e.g. Italy’s positive image) and the inherently global nature of the luxury industry, can turn foreignness into an asset of foreignness that allows luxury fashion SMEs to pursue internationalization pathways of born globals.Originality/valueThe paper highlights that the global luxury market is not the exclusive domain of MNEs and sheds light on luxury SMEs, overlooked by extant literature. The paper also contributes to understanding early internationalization by highlighting a potential link between internationalization pathways and foreignness and discussed the asset of foreignness by extending it to SMEs.
Exploring the key risk factors impeding the performance of highway construction projects: an evidence from Nigeria
Authors: Akoh Sani Reuben , Sun Ming , Ogunlana Stephen , Mahmud Abba Tahir 
Published: May 2024

Purpose
Construction projects, and particularly highway infrastructures, are known to be major contributors to the socio-economic growth of developing countries. However, these types of projects are infamous for being highly risky due to the interplay of numerous risk factors. This study aims to explore the key risk factors impacting on the performance of highway infrastructure projects in Nigeria from the contextual viewpoint of key industry stakeholders.

Design/methodology/approach
Qualitative data was collected using semi-structured interviews. Specifically, 17 in-depth expert interviews were conducted with experienced stakeholders in the highway sector of the Nigerian construction industry. The collected data was transcribed and analysed using an established coding framework (grounded on case study approach, principles of thematic analysis and saliency analysis).

Findings
Overall, 17 key risks were identified from the data analysis process, and 6 risks were recognised as the most significant, based on the combination of prevalence of occurrence and significance of the coded information. The six top risks were: change in government, corruption, cost of construction materials, inflation, project funding issues and construction project delay. However, the first two of these risks (change in government and corruption) are politically related, which is specific and unique to the setting of Nigeria and thus might be seen as discouraging indicators that could have an impact on attracting foreign investors/contractors to Nigeria.

Originality/value
The study addressed the gap related with identifying context-specific risk factors impeding the performance of highway projects in Nigeria from the viewpoints of industry experts. It is expected that the findings will provide a better insight into the various risk factors and thus aid relevant policymakers to provide context-specific mitigating strategies.
The workplace of the future: the COVID-19 pandemic and working from home in Swiss small businesses
Authors: Peter Marc K. , Wuersch Lucia , Neher Alain , Lindeque Johan Paul , Mändli Lerch Karin 
Published: May 2024

PurposeMicro and small enterprises (MSE) play a critical role in the Swiss economy but had no meaningfully adopted working from home (WFH) policy before the COVID-19 crisis. The timing of the study’s data collection allowed a unique assessment of Swiss MSEs’ adoption of WFH enabled by the adoption of digital technologies due to the first government-mandated COVID-19 lockdown. The study also set out to assess the permanence of any changes in the adoption of WFH by MSEs after initial government COVID-19 restrictions ended.Design/methodology/approachThe study uses a threefold theoretical framework combining social, technical and spatial dimensions. Data were collected via telephone interviews. The utilised sampling frame included 153,000 small businesses with 4–49 employees, and the realised sample for the study was 503 interviews with MSE owners and managing directors (MDs).FindingsThe Swiss government’s COVID-19 crisis lockdown policies accelerated the digital transformation of work by employees in Swiss MSEs by increasing the number of employees WFH. However, the number of MSEs with WFH employees decreased after the first lockdown ended. Small business leadership is an important influence on the persistence of any increases in WFH.Originality/valueThe data collection uniquely captures the effects of externally driven digital transformation of work in small businesses by the adoption of WFH. The findings show that small businesses can rapidly learn new ways of working and support the claim that Swiss MSE MDs play a critical role in the adoption of WFH. They also confirm the importance of digital leadership and culture for realising the potential of WFH in small businesses.