bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Influence of Substituents in Diphosphine Ligands on the Hydrogenation Activity and Selectivity of the Corresponding Rhodium Complexes as Exemplified by ButiPhane
Authors: Fischer Christian , Schulz Stefan , Drexler Hans‐Joachim , Selle Carmen , Lotz Matthias , Sawall Mathias , Neymeyr Klaus , Heller Detlef 
Published: November 2011

AbstractThe influence of substituents in ButiPhane ligands (with R=Me, Et, iPr) on the hydrogenation activity and selectivity of the corresponding rhodium complexes has been quantitatively assessed. Increasingly demanding substituents negatively affect the reduction rate of 1,5‐cyclooctadiene in catalyst precursors en route to catalytically active MeOH–solvent complexes. The same trend as to activity is observed in the hydrogenation of prochiral olefins [methyl‐(Z)‐α‐acetamidocinnamate, methyl (Z)‐3‐N‐acetylamino‐3‐methylacrylate, and methyl (Z)‐3‐N‐acetylamino‐3‐phenylacrylate], which however is counterbalanced by an increase in the stereorecognition ability of the bulkier catalysts.
Chemical Synthesis of Helicobacter pylori Lipopolysaccharide Partial Structures and their Selective Proinflammatory Responses
Authors: Shimoyama Atsushi , Saeki Akinori , Tanimura Natsuko , Tsutsui Hiroko , Miyake Kensuke , Suda Yasuo , Fujimoto Yukari , Fukase Koichi 
Published: November 2011

AbstractHelicobacter pylori is a common cause of gastroduodenal inflammatory diseases such as chronic gastritis and peptic ulcers and also an important factor in gastric carcinogenesis. Recent reports have demonstrated that bacterial inflammatory processes, such as stimulation with H. pylori lipopolysaccharide (LPS), initiate atherosclerosis. To establish the structures responsible for the inflammatory response of H. pylori LPS, we synthesized various kinds of lipid A structures (i.e., triacylated lipid A and Kdo‐lipid A compounds), with or without the ethanolamine group at the 1‐phosphate moiety, by a new divergent synthetic route. Stereoselective α‐glycosylation of Kdo N‐phenyltrifluoroacetimidate was achieved by use of microfluidic methods. None of the lipid A and Kdo‐lipid A compounds were a strong inducer of IL‐1β, IL‐6, or IL‐8, suggesting that H. pylori LPS is unable to induce acute inflammation. In fact, the lipid A and Kdo‐lipid A compounds showed antagonistic activity against cytokine induction by E. coli LPS, except for the lipid A compound with the ethanolamine group, which showed very weak agonistic activity. On the other hand, these H. pylori LPS partial structures showed potent IL‐18‐ and IL‐12‐inducing activities. IL‐18 has been shown to correlate with chronic inflammation, so H. pylori LPS might be implicated in the chronic inflammatory responses induced by H. pylori. These results also indicated that H. pylori LPS can modulate the immune response: NF‐κB activation through hTLR4/MD‐2 was suppressed, whereas production of IL‐18 and IL‐12 was promoted.
Anthraquinone as a Redox Label for DNA: Synthesis, Enzymatic Incorporation, and Electrochemistry of Anthraquinone‐Modified Nucleosides, Nucleotides, and DNA
Authors: Balintová Jana , Pohl Radek , Horáková Petra , Vidláková Pavlína , Havran Luděk , Fojta Miroslav , Hocek Michal 
Published: November 2011

AbstractModified 2′‐deoxynucleosides and deoxynucleoside triphosphates (dNTPs) bearing anthraquinone (AQ) attached through an acetylene or propargylcarbamoyl linker at the 5‐position of pyrimidine (C) or at the 7‐position of 7‐deazaadenine were prepared by Sonogashira cross‐coupling of halogenated dNTPs with 2‐ethynylanthraquinone or 2‐(2‐propynylcarbamoyl)anthraquinone. Polymerase incorporations of the AQ‐labeled dNTPs into DNA by primer extension with KOD XL polymerase have been successfully developed. The electrochemical properties of the AQ‐labeled nucleosides, nucleotides, and DNA were studied by cyclic and square‐wave voltammetry, which show a distinct reversible couple of peaks around −0.4 V that make the AQ a suitable redox label for DNA.
A Highly α‐Stereoselective Synthesis of Oligosaccharide Fragments of the Vi Antigen from Salmonella typhi and Their Antigenic Activities
Authors: Yang Lin , Zhu Jingjing , Zheng Xiu‐Jing , Tai Guihua , Ye Xin‐Shan 
Published: November 2011

AbstractIn this paper, a convenient approach to the synthesis of the repeating α‐(1→4)‐linked N‐acetyl galactosaminuronic acid units from the capsular polysaccharide of Salmonella typhi is reported. The exclusively α‐stereoselective glycosylation reactions were achieved by using oxazolidinone‐protected glycosides as building blocks based on a pre‐activation protocol. Di‐, tri‐, and tetrasaccharides were prepared by this short and efficient approach in high yields. The enzyme‐linked immunosorbent assay experiments show that our synthetic tri‐ and tetrasaccharide had much higher antigenic activities than previously reported ones in the inhibition of antibody binding by the native polysaccharide. The results demonstrate that the antigenic activities of saccharides can be strengthened greatly by increasing the number of acetyl groups present.
ChemInform Abstract: Structure Solution of the High‐Pressure Phase of CuWO4 and Evolution of the Jahn—Teller Distortion.
Authors: Ruiz‐Fuertes J. , Friedrich A. , Pellicer‐Porres J. , Errandonea D. , Segura A. , Morgenroth W. , Haussuehl E. , Tu C.‐Y. , Polian A. 
Published: November 2011

AbstractThe structural behavior of the title compound up to 33.9 GPa is characterized by single crystal XRD and EXAFS.
ChemInform Abstract: Tl2Hg3Q4 (Q: S, Se, and Te): High‐Density, Wide‐Band‐Gap Semiconductors.
Authors: Johnsen Simon , Peter Sebastian C. , Nguyen Sandy L. , Song Jung‐Hwan , Jin Hosub , Freeman Arthur J. , Kanatzidis Mercouri G. 
Published: November 2011

AbstractThe title compounds are prepared in 2—5 g batches by reactions of Tl2Q (Q: S, Se, and Te) and HgQ in a 1:3 stoichiometry (sealed carbon‐coated tubes, 823 K, 2 d; annealing at 623 K, 3 weeks).
ChemInform Abstract: The First Examples of Selenidogermanate Salts with Lanthanide Complex Counter Cations: Solvothermal Syntheses and Characterizations of [{Ln(en)3}2(μ‐OH)2] Ge2Se6 (Ln: Eu, Ho) and [{Ho(dien)2}2(μ‐OH)2] Ge2Se6.
Authors: Tang Weiwei , Liang Jingjing , Jiang Wenqing , Wu Bing , Zhang Yong , Jia Dingxian 
Published: November 2011

AbstractThe first selenidogermanate salts with lanthanide complex counter cations (IVa, b) and (V) crystallize in the monoclinic space group P21/n with Z = 2.
ChemInform Abstract: Palladium NCN and CNC Pincer Complexes as Exceptionally Active Catalysts for Aerobic Oxidation in Sustainable Media.
Authors: Urgoitia Garazi , SanMartin Raul , Herrero Maria Teresa , Dominguez Esther 
Published: November 2011

AbstractThe oxidation of secondary alcohols and benzylic methylene compounds under aerobic conditions is achieved employing exceptionally low loadings of palladacycle catalysts.
ChemInform Abstract: Ru—η6‐benzene—Phosphine Complex‐Catalyzed Transfer Hydrogenation of Ketones.
Authors: Wang Lei , Yang Qin , Fu Hai‐Yan , Chen Hua , Yuan Mao‐Lin , Li Rui‐Xiang 
Published: November 2011

AbstractA new ruthenium complex is an efficient catalyst for the reactions of various substituted aryl, alkyl, and alicyclic ketones.
ChemInform Abstract: Synthesis of o‐(Dimethylamino)aryl Ketones and Acridones by the Reaction of 1,1‐Dialkylhydrazones and Arynes.
Authors: Dubrovskiy Anton V. , Larock Richard C. 
Published: November 2011

AbstractA variety of ortho‐dimethylamino‐ or ortho‐morpholino‐aryl ketones is prepared from aromatic, heteroaromatic and alkenyl‐derived hydrazones and arynes, generated from ortho‐trimethylsilylaryl triflates.
ChemInform Abstract: Reaction of 1‐(Oxiran‐2‐ylmethyl)‐1H‐indole‐3‐carboxaldehyde with Amines.
Authors: Suzdalev Konstantin F. , Den'kina Sophia , Starikova Alena A. , Dvurechensky Vladimir V. , Kletsky Mikhail E. , Burov Oleg N. 
Published: November 2011

AbstractReaction of title compound (I) with anilines (II) results in an oxirane ring opening furnishing amino alcohols (III).
ChemInform Abstract: Regioselective Synthesis of Sulfonylpyrazoles via Base‐Mediated Reaction of Diazosulfones with Nitroalkenes and a Facile Entry into Withasomnine.
Authors: Kumar Rahul , Namboothiri Irishi N. N. 
Published: November 2011

AbstractThe process can be applied to various substrates and affords only one type of regioisomer with concomitant introduction of many functionalities.
ChemInform Abstract: Some New Information on the Formation of Substituted 4‐Amino‐1‐substituted Phenyl‐1H‐pyrazoles from β‐Enaminones and Diazonium Tetrafluoroborates.
Authors: Simunek Petr , Machacek Vladimir , Svobodova Marketa , Ruzicka Ales 
Published: November 2011

AbstractThe formation of the products depends on the steric effect of the substituent at the ortho‐position in the aryl group of the diazonium salt, cf.
ChemInform Abstract: Synthesis of 3‐Substituted 5‐(2‐Thienyl)isoxazoles.
Authors: Potkin V. I. , Petkevich S. K. , Kurman P. V. 
Published: November 2011

AbstractThienyl trichloroallyl ketone (I), a synthetic equivalent of β‐chlorovinyl ketones, reacts with hydroxylamine to an intermediate dichloromethyl‐substituted isoxazole which upon reaction with a second hydroxylamine molecule affords the hydoxyiminomethyl‐substituted isoxazole (II).
ChemInform Abstract: Enantioselective N‐Heterocyclic Carbene‐Catalyzed Michael Addition to α,β‐Unsaturated Aldehydes by Redox Oxidation.
Authors: Rong Zi‐Qiang , Jia Min‐Qiang , You Shu‐Li 
Published: November 2011

AbstractThe reaction of various aromatic α,β‐unsaturated aldehydes with dicarbonyl compounds under conditions A) provides enantioenriched substituted 3,4‐dihydro‐α‐pyrones.
ChemInform Abstract: Ni(II) Salts and 2‐Propanol Effect Catalytic Reductive Coupling of Epoxides and Alkynes.
Authors: Beaver Matthew G. , Jamison Timothy F. 
Published: November 2011

AbstractIsopropanol serves not only as a solvent but also as a reducing agent to provide the desired homoallylic alcohol product and regenerate the active Ni(0) catalyst.
ChemInform Abstract: Regioselective Synthesis of Isochromenones by Iron(III)/PhSeSePh‐Mediated Cyclization of 2‐Alkynylaryl Esters.
Authors: Speranca Adriane , Godoi Benhur , Pinton Simone , Back Davi F. , Menezes Paulo H. , Zeni Gilson 
Published: November 2011

AbstractIn the absence of the dichalcogenides, isochromenones are also available.
ChemInform Abstract: An Efficient Non‐Ionic Surfactant Catalyzed Multicomponent Synthesis of Novel Benzylamino Coumarin Derivative via Mannich‐Type Reaction in Aqueous Media.
Authors: Kumar Atul , Gupta Maneesh Kumar , Kumar Mukesh 
Published: November 2011

AbstractAn interesting synthesis of benzylamino coumarin derivatives and analogues of type (XI) utilizes a micelle‐promoted three‐component reaction.
ChemInform Abstract: Synthesis of 2,5‐Dihydropyridine Derivatives by Gold‐Catalyzed Reactions of β‐Ketoesters and Propargylamines.
Authors: Fananas Francisco J. , Arto Tamara , Mendoza Abraham , Rodriguez Felix 
Published: November 2011

AbstractIsomeric forms of 2,5‐dihydropyridine derivatives are not observed.
ChemInform Abstract: Facile, Four‐Component, Domino Reactions for the Regioselective Synthesis of Tetrahydrobenzo[g]quinolines.
Authors: Bala Balasubramanian Devi , Balamurugan Kamaraj , Perumal Subbu 
Published: November 2011

AbstractVarious title compounds, which represent scaffolds of natural products, are available following either conventional conditions or microwave chemistry.
ChemInform Abstract: Synthesis of Some Triazolophthalazine Derivatives for Their Antiinflammatory and Antimicrobial Activities.
Authors: Habib Nargues S. , Farghaly Ahmed M. , Ashour Fawzia A. , Bekhit Adnan A. , Abd El Razik Heba A. , Abd El Azeim Tarek 
Published: November 2011

AbstractA variety of novel triazolophthalazine derivatives is synthesized using 3‐oxopropenyltriazolophthalazinones (III) as key intermediates.
ChemInform Abstract: Synthesis of Functionalized Pyridazin‐3(2H)‐ones via Selective Bromine—Magnesium Exchange and Lactam Directed ortho C—H Magnesiation.
Authors: Verhelst Tom , Maes Jens , Liu Zuming , Sergeyev Sergey , Maes Bert U. W. 
Published: November 2011

AbstractIn the presence of Mst‐MgBr the pyridazinone (I) can undergo selective substitution at C‐5 to afford products like (III), (V), and (VI).
ChemInform Abstract: Reactions of N‐Arylmaleimides with 3‐Amino‐1,2,4‐triazole and 2‐Aminobenzimidazole.
Authors: Rudenko Roman V. , Komykhov Sergey A. , Musatov Vladimir I. , Konovalova Irina S. , Shishkin Oleg V. , Desenko Sergey M. 
Published: November 2011

AbstractThe selective formation of the products (III) and (IV) depends on the solvents and the reaction time.
ChemInform Abstract: Synthesis of Tetrazolo[1,5‐a]quinoxaline Based Azetidinones (X) and Thiazolidinones (XII) as Potent Antibacterial and Antifungal Agents.
Authors: Kumar Shiv , Khan S. A. , Alam Ozair , Azim Rizwan , Khurana Atul , Shaquiquzzaman M. , Siddiqui Nadeem , Ahsan Waquar 
Published: November 2011

AbstractSome of the new title compounds exhibit promising antibacterial and for antifungal activities.
ChemInform Abstract: Palladium‐Catalyzed Highly Chemo‐, Regio‐ and Stereoselective Synthesis of Eight‐ to Ten‐Membered Lactones from Allenyl 3‐Oxoalkanoates and Organic Halides.
Authors: Wan Baoqiang , Jia Guochen , Ma Shengming 
Published: November 2011

AbstractThe reaction tolerates a wide range of organic halides and functionalized allenes 2‐Substituted allenes require higher temperature and longer reaction time with the growing chain length of the substituents [cf.
ChemInform Abstract: Limonoids from Seeds of Thai Xylocarpus moluccensis
Authors: Ravangpai Warin , Sommit Damrong , Teerawatananond Thapong , Sinpranee Nuntawan , Palaga Tanapat , Pengpreecha Somchai , Muangsin Nongnuj , Pudhom Khanitha 
Published: November 2011

Abstractisolation, characterization and antiinflammatory activity of the new andirobin, thaimoluccensin A (I), the new phragmalin‐type limonoids, thaimoluccensins B (II) and C (III) and eight known compounds
ChemInform Abstract: The First Synthesis and Molecular Docking Studies of Diastereomerically Pure Substituted 4‐Amino‐7‐hydroxyheptanoic Acids.
Authors: Sukhorukov Alexey Yu. , Andryushkevich Svetlana O. , Chilov Ghermes G. , Zeifman Alexey A. , Svitanko Igor V. , Ioffe Sema L. 
Published: November 2011

AbstractTitle compounds (III) are synthesized diastereoselectivity.
ChemInform Abstract: A Novel and Highly Stereoselective Synthesis of 2‐Substituted Perhydrofuro[2,3‐b]pyran Derivatives.
Authors: Ma Xiaofeng , Tian Qiang , Tang Qin , Zhao Jinzhong , Shao Huawu 
Published: November 2011

AbstractTreatment of thioglycoside (I) with various acceptors under conditions A) allows the stereoselective preparation of the required subunits in good to excellent yields.
ChemInform Abstract: General and Modular Synthesis of Isomeric 5‐Substituted Pyridin‐2‐yl and 6‐Substituted Pyridin‐3‐yl C‐Ribonucleosides Bearing Diverse Alkyl, Aryl, Hetaryl, Amino, Carbamoyl, and Hydroxy Groups.
Authors: Stefko Martin , Slavetinska Lenka , Klepetarova Blanka , Hocek Michal 
Published: November 2011

AbstractNew and general methods to prepare biologically important title nucleosides are reported.
ChemInform Abstract: Sodium Borohydride/Methoxydiethylborane Mediated syn‐1,3‐Stereoselective Total Synthesis of Herbarumin‐III.
Authors: Yadav J. S. , Narasimhulu G. , Reddy Y. Vikram , Reddy B. V. Subba , Ghamdi Ahmad Al Khazim Al 
Published: November 2011

AbstractA total synthesis of the 10‐membered macrolide herbarumin‐III is described.
ChemInform Abstract: Heteropoly Acid‐Based Materials for Reversible H2 Storage as Protons and Electrons under Mild Conditions.
Authors: Itagaki Shintaro , Yamaguchi Kazuya , Mizuno Noritaka 
Published: November 2011

AbstractA composite of Pt and H4SiW12O40 reversibly stores hydrogen at 40 kPa H2 and 308 K.
ChemInform Abstract: 3‐(3‐Phenoxybenzyl)amino‐β‐carboline: A Novel Antitumor Drug Targeting α‐Tubulin.
Authors: Konakahara Takeo , et al. et al. 
Published: November 2011

AbstractA series of β‐carboline derivatives, substituted at the 1‐ or 3‐position with benzylamino groups, is prepared and their cytotoxic effects on a human cancer cell line are determined.
ChemInform Abstract: Design and Synthesis of Pyridine‐Substituted Itraconazole Analogues with Improved Antifungal Activities, Water Solubility and Bioavailability.
Authors: Liu Yu , Liu Zining , Cao Xufeng , Liu Xin , He Huili , Yang Yushe 
Published: November 2011

AbstractReplacement of the phenyl ring in the itraconazole side chain with pyridine as a bioisostere yields a new class of antifungal agents.
An Efficient Palladium Catalyst System for the Oxidative Carbonylation of Glycerol to Glycerol Carbonate
Authors: Hu Jianglin , Gu Yanlong , Guan Zhenhong , Li Jinjin , Mo Wanling , Li Tao , Li Guangxing 
Published: November 2011

AbstractGlycerol carbonate can be readily synthesized from the oxidative carbonylation of glycerol catalyzed by PdCl2(phen) (phen=1,10‐phenanthroline) with the aid of CuI. High conversion (95 %) and selectivity (98 %) are achieved and the turnover frequency (TOF) reaches 455 h−1. Furthermore, a new zeolite‐Y‐confined Pd catalyst, PdCl2(phen)@Y, has been successfully prepared by a ‘‘flexible ligand’’ method. The structure and composition of the heterogeneous catalyst have been characterized by atomic absorption spectroscopy, elemental analysis, N2 sorption, XRD, FTIR, solid‐state NMR, and X‐ray photoelectron spectroscopy. This catalyst exhibits a comparable activity to its homogeneous counterpart and could be reused five times without significant decrease in activity. This is the most efficient heterogeneous system for synthesizing glycerol carbonate by the oxidative carbonylation of glycerol to date.
Fuzzy constrained optimization of eco‐friendly reservoir operation using self‐adaptive genetic algorithm: a case study of a cascade reservoir system in the Yalong River, China
Authors: Han Jing‐Cheng , Huang Guo‐He , Zhang Hua , Zhuge Yi‐Si , He Li 
Published: November 2011

ABSTRACTWith the increasing demands for hydropower development in China, it is particularly important to implement eco‐friendly reservoir operation in consideration of the vulnerability of downstream aquatic environment. In this paper, a fuzzy constrained nonlinear programming model is presented. Fuzzy programming is used to deal with the inherent imprecision and vagueness in constraints, and a self‐adaptive genetic algorithm with simulated binary crossover is proposed for searching for the optimal reservoir operating rules. First, the fuzzy reservoir operation model is transformed into two deterministic sub‐models. Self‐adaptive genetic algorithm is then used to generate optimal solutions by applying penalty functions to integrate constraints into the objective function to form the fitness function. To achieve a final compromise between the fuzzy objective and the constraints, a ‘max‐min’ decision principle is incorporated into the optimization process to obtain satisfactory operating schemes. The methodology is demonstrated through a cascade system of reservoirs in the Yalong River, southwest China. A monthly reservoir operation model, which considered downstream ecological flow requirements as fuzzy constraints, is developed to optimize eco‐friendly reservoir operation with the objective of maximizing total hydropower generation. Monthly operating rules are generated for two cascade reservoirs, and the optimal hydropower generation is also obtained. Results indicate that the proposed approach can effectively improve the operation of the cascade reservoir system and fulfill the flow requirements of the downstream ecosystem that are expressed as fuzzy sets. It is a useful tool for generating optimal strategy to achieve an eco‐friendly reservoir operation under uncertainty. Copyright © 2011 John Wiley & Sons, Ltd.
Stable isotopes reveal linkages among ecohydrological processes in a seasonally dry tropical montane cloud forest
Authors: Goldsmith Gregory R. , Muñoz‐Villers Lyssette E. , Holwerda Friso , McDonnell Jeffrey J. , Asbjornsen Heidi , Dawson Todd E. 
Published: November 2011

ABSTRACTDespite their critical role as freshwater resources and their vulnerability to anthropogenic pressures, our knowledge of the ecohydrology of tropical montane cloud forests remains limited. Here, we use a dual stable isotope approach (δ2H and δ18O) to trace water inputs, fluxes, and pools through a seasonally dry tropical montane cloud forest in central Veracruz, Mexico. We found strong seasonal variation in the isotope composition of precipitation inputs (δ2H ~130‰ and δ18O ~18‰), with significantly more depleted wet‐season values as compared with dry‐season values. These seasonal differences are subject to inter‐annual variation, as reflected by shifts in the local meteoric water line. Even at the peak of the dry season, stable isotope values of plant xylem water from six different deciduous and evergreen species occurring in the understory and canopy of mature and secondary forests were all consistent with the use of shallow soil water (20–60 cm). Alternative limiting factors, such as nutrient distribution along the soil profile, may be strongly contributing to plant rooting patterns. Stable isotope values of soil water were evaporatively enriched compared with precipitation inputs, whereas stream values plotted with precipitation on the local meteoric water line. In contrast to current hydrologic models, this indicates the presence of two distinct soil water pools, one highly mobile pool of precipitation that contributes to streams and a second less mobile pool of soil water that contributes to plant fluxes. This comprehensive perspective can provide the basis for generating process‐based models of ecohydrology in the future. Copyright © 2011 John Wiley & Sons, Ltd.
Concentration‐Dependent Dehydrogenation of Ammonia–Borane/Triglyme Mixtures
Authors: Kostka Johannes F. , Schellenberg René , Baitalow Felix , Smolinka Tom , Mertens Florian 
Published: November 2011

AbstractThe dehydrogenation reaction of the hydrogen‐storage compound ammonia–borane (AB) dissolved in triglyme (TG) reveals an unexpected but favourable concentration dependence of its dehydrogenation behaviour. Formal reaction‐order considerations and 11B NMR spectroscopic analytics point towards a complex AB decomposition and hydrogen‐release scheme that in highly concentrated solutions partly begins to resemble that of the solid‐state case. The analysis of the gas‐release characteristics identified two hydrogen desorption events that display an increasing peak overlap with increasing initial AB concentration. 11B NMR spectroscopic studies indicate that the concentration‐dependent stability of the intermediate diammoniate of diborane, the presence of which appears to influence the rates of several dehydrogenation steps by interacting with various other intermediates, is one of the key factors for the overall hydrogen release.