bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Regional Modeling Study of Climate Change Impacts on Warm-Season Precipitation in the Central United States*
Authors: Bukovsky Melissa S. , Karoly David J. 
Published: November 2010

Abstract
In this study, the Weather Research and Forecasting (WRF) model is employed as a nested regional climate model to dynamically downscale output from the National Center for Atmospheric Research’s (NCAR’s) Community Climate System Model (CCSM) version 3 and the National Centers for Environmental Prediction (NCEP)–NCAR global reanalysis (NNRP). The latter is used for verification of late-twentieth-century climate simulations from the WRF.
This analysis finds that the WRF is able to produce precipitation that is more realistic than that from its driving systems (the CCSM and NNRP). It also diagnoses potential issues with and differences between all of the simulations completed. Specifically, the magnitude of heavy 6-h average precipitation events, the frequency distribution, and the diurnal cycle of precipitation over the central United States are greatly improved. Projections from the WRF for late-twenty-first-century precipitation show decreases in average May–August (MJJA) precipitation, but increases in the intensity of both heavy precipitation events and rain in general when it does fall. A decrease in the number of 6-h periods with rainfall accounts for the overall decrease in average precipitation. The WRF also shows an increase in the frequency of very heavy to extreme 6-h average events, but a decrease in the frequency of all events lighter than those over the central United States. Overall, projections from this study suggest an increase in the frequency of both floods and droughts during the warm season in the central United States.
The Role of the Wind–Evaporation–Sea Surface Temperature (WES) Feedback as a Thermodynamic Pathway for the Equatorward Propagation of High-Latitude Sea Ice–Induced Cold Anomalies
Authors: Mahajan Salil , Saravanan R. , Chang Ping 
Published: November 2010

Abstract
The role of the wind–evaporation–sea surface temperature (WES) feedback in the propagation of the high-latitude cooling signal to the tropical oceans using the NCAR atmospheric Community Climate Model (CCM3) coupled thermodynamically to a slab-ocean model (SOM) is studied. Abruptly imposed additional Northern Hemispheric sea ice cover equivalent to the Last Glacial Maximum (LGM; 18 kyr BP) in the model causes a Northern Hemisphere–wide cooling, as well as the generation and amplification of an anomalous cross-equatorial meridional SST dipole associated with a southward migration of the intertropical convergence zone (ITCZ) stabilizing within a period of 5 yr. In experiments where the WES feedback is switched off explicitly by modifying the sensible and latent heat flux bulk aerodynamic formulations over the oceans in CCM3, imposed Northern Hemispheric sea ice also results in widespread northern cooling at the same rate as the unmodified run, suggesting that the WES feedback is not essential in the propagation of the high-latitude cooling signal to the deep tropics. However, the WES-off experiment generates a weaker cross-equatorial SST dipole with a modest southward movement of the ITCZ, suggesting that the WES feedback is responsible for amplifying SST and atmospheric anomalies in the deep tropics during their transition to the new equilibrium state. The propagation of high-latitude cooling to the deep tropics is proposed to be caused by the decrease of near-surface specific humidity in the northern tropics.
A New Global Set of Downscaled Temperature Scenarios
Authors: Benestad Rasmus E. 
Published: November 2010

Abstract
A new set of empirical–statistical downscaled seasonal mean temperature scenarios is presented for locations spread across all continents. These results are based on the Coupled Model Intercomparison Project phase 3 (CMIP3) simulations, the Special Report on Emissions Scenarios (SRES) A1B story line, and arguably represent the largest downscaled multimodel ensemble to date in terms of worldwide distribution, length of time interval, and the number of global climate model simulations. The ensemble size of ∼50 members enables a crude uncertainty analysis for simulated future local temperature, and maps have been constructed for Europe, Africa, and the northwestern part of Russia and Scandinavia of the ensemble mean and 95th percentile for seasonal mean temperatures projected for 2100, as well as simulated probabilities for low or high temperatures. The results are stored as matrices of coefficients describing best-fit fifth-order polynomials, used to approximate the long-term trends in the temperature. These results suggest that the 95th percentile of the summer temperature is expected to increase 3°–5°C by 2100 over most of Europe, and that there will be reduced probabilities of winter temperature lower than 0°C for all European locations, with the greatest reduction of ∼60% in areas where the winter temperature presently is around freezing point. A similar analysis for Africa suggests that the June–August mean temperatures may exceed 35°C in isolated regions by 2100. For the northwestern part of Russia and Scandinavia, the analysis yields a 4.5°–7.5°C increase for the ensemble mean December–February temperature, with the most pronounced warming in the northeast, north, and over Finnmark County in Norway.
Are Anthropogenic Aerosols Responsible for the Northwest Australia Summer Rainfall Increase? A CMIP3 Perspective and Implications
Authors: Cai Wenju , Cowan Tim , Sullivan Arnold , Ribbe Joachim , Shi Ge 
Published: November 2010

Abstract
Severe rainfall deficiencies have plagued southern and eastern Australian regions over the past decades, where the long-term rainfall is projected to decrease. By contrast, there has been an increase over northwest Australia (NWA) in austral summer, which, if it continues, could be an important future water resource. If increasing anthropogenic aerosols contribute to the observed increase in summer rainfall, then, as anthropogenic aerosols are projected to decrease, what will the likely impact over NWA be? This study uses output from 24 climate models submitted to phase 3 of the Coupled Model Intercomparison Project (CMIP3) with a total of 75 experiments to provide a multimodel perspective. The authors find that none of the ensemble averages, either with both the direct and indirect anthropogenic aerosol effect (10 models, 32 experiments) or with the direct effect only (14 models, 43 experiments), simulate the observed NWA rainfall increase. Given this, it follows that a projected rainfall reduction is not due to a projected decline in future aerosol concentrations. The authors show that the projected NWA rainfall reduction is associated with an unrealistic and overly strong NWA rainfall teleconnection with the El Niño–Southern Oscillation (ENSO). The unrealistic teleconnection is primarily caused by a model equatorial Pacific cold tongue that extends too far into the western Pacific, with the ascending branch of the Walker circulation situated too far west, exerting an influence on rainfall over NWA rather than over northeast Australia. Models with a greater present-day ENSO amplitude produce a greater reduction in the Walker circulation and hence a greater reduction in NWA rainfall in a warming climate. Hence, the cold bias and its impact represent a source of uncertainty for climate projections.
Intermittent Intense Turbulent Mixing under Ice in the Laptev Sea Continental Shelf
Authors: Lenn Yueng-Djern , Rippeth Tom P. , Old Chris P. , Bacon Sheldon , Polyakov Igor , Ivanov Vladimir , Hölemann Jens 
Published: November 2010

Abstract
Vertical mixing in the bottom boundary layer and pycnocline of the Laptev Sea is evaluated from a rapidly sampled 12-h time series of microstructure temperature, conductivity, and shear observations collected under 100% sea ice during October 2008. The bottom boundary turbulent kinetic energy dissipation was observed to be enhanced (ε ∼ 10−4 W m−3) beyond background levels (ε ∼ 10−6 W m−3), extending up to 10 m above the seabed when simulated tidal currents were directed on slope. Upward heat fluxes into the halocline-class waters along the Laptev Sea seabed peaked at ∼4–8 W m−2, averaging out to ∼2 W m−2 over the 12-h sampling period. In the Laptev Sea pycnocline, an isolated 2-h episode of intense dissipation (ε ∼ 10−3 W m−3) and vertical diffusivities was observed that was not due to a localized wind event. Observations from an acoustic Doppler current meter moored in the central Laptev Sea near the M2 critical latitude are consistent with a previous model in which mixing episodes are driven by an enhancement of the pycnocline shear resulting from the alignment of the rotating pycnocline shear vector with the under-ice stress vector. Upward cross-pycnocline heat fluxes from the Arctic halocline peaked at ∼54 W m−2, resulting in a 12-h average of ∼12 W m−2. These results highlight the intermittent nature of Arctic shelf sea mixing processes and how these processes can impact the transformation of Arctic Ocean water masses. The observations also clearly demonstrate that absence or presence of sea ice profoundly affects the availability of near-inertial kinetic energy to drive vertical mixing on the Arctic shelves.
An Estimate of Increases in Storm Surge Risk to Property from Sea Level Rise in the First Half of the Twenty-First Century
Authors: Hoffman Ross N. , Dailey Peter , Hopsch Susanna , Ponte Rui M. , Quinn Katherine , Hill Emma M. , Zachry Brian 
Published: November 2010

Abstract
Sea level is rising as the World Ocean warms and ice caps and glaciers melt. Published estimates based on data from satellite altimeters, beginning in late 1992, suggest that the global mean sea level has been rising on the order of 3 mm yr−1. Local processes, including ocean currents and land motions due to a variety of causes, modulate the global signal spatially and temporally. These local signals can be much larger than the global signal, and especially so on annual or shorter time scales.
Even increases on the order of 10 cm in sea level can amplify the already devastating losses that occur when a hurricane-driven storm surge coincides with an astronomical high tide. To quantify the sensitivity of property risk to increasing sea level, changes in expected annual losses to property along the U.S. Gulf and East Coasts are calculated as follows. First, observed trends in sea level rise from tide gauges are extrapolated to the year 2030, and these changes are interpolated to all coastal locations. Then a 10 000-yr catalog of simulated hurricanes is used to define critical wind parameters for each event. These wind parameters then drive a parametric time-evolving storm surge model that accounts for bathymetry, coastal geometry, surface roughness, and the phase of the astronomical tide. The impact of the maximum storm surge height on a comprehensive inventory of commercial and residential property is then calculated, using engineering models that take into account the characteristics of the full range of construction types.
Average annual losses projected to the year 2030 are presented for regions and key states and are normalized by aggregate property value on a zip code by zip code basis. Comparisons to the results of a control run reflecting the risk today quantify the change in risk per dollar of property on a percentage basis. Increases in expected losses due to the effect of sea level rise alone vary by region, with increases of 20% or more being common. Further sensitivity tests quantify the impact on the risk of sea level rise plus additional factors, such as changes in hurricane frequency and intensity as a result of rising sea surface temperatures.
Effect of Shoulder Stabilization on Career Length in National Football League Athletes
Authors: Brophy Robert H. , Gill Corey S. , Lyman Stephen , Barnes Ronnie P. , Rodeo Scott A. , Warren Russell F. 
Published: November 2010

Background: Shoulder instability and surgical stabilization are common in college football athletes. The effect of shoulder stabilization during college on the length of an athlete’s career in the National Football League (NFL) has not been well examined. Hypothesis: Athletes with a history of shoulder stabilization before the NFL combine have a shorter career than do matched controls. Study Design: Cohort study; Level of evidence, 3. Methods: A database containing the injury history and career NFL statistics of athletes from 1987 to 2000 was used to match athletes with a history of shoulder stabilization and no other surgery or significant injury to controls without a history of any previous surgery or significant injury. Athletes were matched by position, year drafted, round drafted, and additional minor injury history. Results: Forty-two athletes with a history of shoulder stabilization were identified and matched with controls. A history of shoulder stabilization significantly reduced the length of career in terms of years (5.2 ± 3.9 vs 6.9 ± 3.6 years; P = .01) and games played (56 ± 53 vs 77 ± 50, P = .03) as compared with controls. By position, linemen and linebackers (20 athletes) with a history of shoulder stabilization had a significantly shorter career in years (4.7 ± 3.8 vs 6.7 ± 3.4 years; P = .049) and games played (51 ± 58 vs 81 ± 48; P = .046) than did controls. Among the other positions (22 athletes), the difference was not statistically significant in this small cohort. Conclusion: A history of shoulder stabilization shortens the expected career of a professional football player, particularly for linemen and linebackers. Further research is warranted to better understand how these injuries and surgeries affect an athlete’s career and what can be done to improve the long-term outcome after treatment.
Osteoclast-gene expression profiling reveals osteoclast-derived CCR2 chemokines promoting myeloma cell migration
Authors: Moreaux Jerome , Hose Dirk , Kassambara Alboukadel , Reme Thierry , Moine Philippe , Requirand Guilhem , Goldschmidt Hartmut , Klein Bernard 
Published: November 2010

Abstract
Multiple myeloma is characterized by the clonal expansion of malignant plasma cells (multiple myeloma cells [MMCs]), in the bone marrow. Osteolytic bone lesions are detected in 80% of patients because of increased osteoclastic bone resorption and reduced osteoblastic bone formation. MMCs are found closely associated with sites of increased bone resorption. Osteoclasts strongly support MMC survival in vitro. To further elucidate the mechanisms involved in osteoclast/MMC interaction, we have identified 552 genes overexpressed in osteoclasts compared with other bone marrow cell subpopulations. Osteoclasts express specifically genes coding for 4 CCR2-targeting chemokines and genes coding for MMC growth factors. An anti-CCR2 monoclonal antibody blocked osteoclast chemoattractant activity for MMC, and CCR2 chemokines are also MMC growth factors, promoting mitogen-activated protein kinase activation in MMC. An anti-insulin growth factor-1 receptor monoclonal antibody completely blocked the osteoclast-induced survival of MMC suppressing both osteoclast and MMC survival. Specific a proliferation-inducing ligand or IL-6 inhibitors partially blocked osteoclast-induced MMC survival. These data may explain why newly diagnosed patients whose MMC express high levels of CCR2 present numerous bone lesions. This study displays additional mechanisms involved in osteoclast/MMC interaction and suggests using CCR2 and/or insulin growth factor-1 targeting strategies to block this interaction and prevent drug resistance.
Sbds is required for Rac2-mediated monocyte migration and signaling downstream of RANK during osteoclastogenesis
Authors: Leung Roland , Cuddy Karl , Wang Yongqiang , Rommens Johanna , Glogauer Michael 
Published: November 2010

AbstractShwachman-Diamond syndrome (SDS) results from mutations in the SBDS gene, characterized by exocrine pancreatic insufficiency and hematologic and skeletal abnormalities. Neutropenia and neutrophil dysfunction are hallmark features of SDS; however, causes for the bone defects are unknown. Dysfunction of bone-resorbing osteoclasts, formed by the fusion of monocytic progenitors derived from the same granulocytic precursors as neutrophils, could be responsible. We report that Sbds is required for in vitro and in vivo osteoclastogenesis (OCG). Sbds-null murine monocytes formed osteoclasts of reduced number and size because of impaired migration and fusion required for OCG. Phenotypically, Sbds-null mice exhibited low-turnover osteoporosis consistent with findings in SDS patients. Western blotting of Rho GTPases that control actin dynamics and migration showed a 5-fold decrease in Rac2, whereas Rac1, Cdc42, and RhoA were unchanged or only mildly reduced. Although migration was rescued on Rac2 supplementation, OCG was not. This was attributed to impaired signaling downstream of receptor activator of nuclear factor-κB (RANK) and reduced expression of the RANK-ligand-dependent fusion receptor DC-STAMP. We conclude that Sbds is required for OCG by regulating monocyte migration via Rac2 and osteoclast differentiation signaling downstream of RANK. Impaired osteoclast formation could disrupt bone homeostasis, resulting in skeletal abnormalities seen in SDS patients.
Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17–secreting T cells
Authors: Dusseaux Mathilde , Martin Emmanuel , Serriari Nacer , Péguillet Isabelle , Premel Virginie , Louis Delphine , Milder Maud , Le Bourhis Lionel , Soudais Claire , Treiner Emmanuel , Lantz Olivier 
Published: November 2010

AbstractMucosal-associated invariant T (MAIT) cells are very abundant in humans and have antimicrobial specificity, but their functions remain unclear. MAIT cells are CD161hiIL-18Rα+ and either CD4−CD8− (DN) or CD8αβint T cells. We now show that they display an effector-memory phenotype (CD45RA−CD45RO+CD95hiCD62Llo), and their chemokine receptor expression pattern (CCR9intCCR7−CCR5hiCXCR6hiCCR6hi) indicates preferential homing to tissues and particularly the intestine and the liver. MAIT cells can represent up to 45% of the liver lymphocytes. They produce interferon-γ and Granzyme-B as well as high levels of interleukin-17 after phorbol myristate acetate + ionomycin stimulation. Most MAIT cells are noncycling cells (< 1% are Ki-67+) and express the multidrug resistance transporter (ABCB1). As expected from this phenotype, MAIT cells are more resistant to chemotherapy than other T-cell populations. These features might also allow MAIT cells to resist the xenobiotics potentially secreted by the gut bacteria. We also show that this population does not appear to have antiviral specificity and that CD8 MAIT cells include almost all the ABCB1+CD161hi CD8 T cells. Together with their already known abundance and antimicrobial specificity, the gut-liver homing characteristics, high expression of ABCB1, and ability to secrete interleukin-17 probably participate in the antibacterial properties of MAIT cells.
mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish
Authors: Ellett Felix , Pase Luke , Hayman John W. , Andrianopoulos Alex , Lieschke Graham J. 
Published: November 2010

AbstractMacrophages and neutrophils play important roles during the innate immune response, phagocytosing invading microbes and delivering antimicrobial compounds to the site of injury. Functional analyses of the cellular innate immune response in zebrafish infection/inflammation models have been aided by transgenic lines with fluorophore-marked neutrophils. However, it has not been possible to study macrophage behaviors and neutrophil/macrophage interactions in vivo directly because there has been no macrophage-only reporter line. To remove this roadblock, a macrophage-specific marker was identified (mpeg1) and its promoter used in mpeg1-driven transgenes. mpeg1-driven transgenes are expressed in macrophage-lineage cells that do not express neutrophil-marking transgenes. Using these lines, the different dynamic behaviors of neutrophils and macrophages after wounding were compared side-by-side in compound transgenics. Macrophage/neutrophil interactions, such as phagocytosis of senescent neutrophils, were readily observed in real time. These zebrafish transgenes provide a new resource that will contribute to the fields of inflammation, infection, and leukocyte biology.
Predicting genome-wide redundancy using machine learning
Authors: Chen Huang-Wen , Bandyopadhyay Sunayan , Shasha Dennis E , Birnbaum Kenneth D 
Published: November 2010

Abstract

Background
Gene duplication can lead to genetic redundancy, which masks the function of mutated genes in genetic analyses. Methods to increase sensitivity in identifying genetic redundancy can improve the efficiency of reverse genetics and lend insights into the evolutionary outcomes of gene duplication. Machine learning techniques are well suited to classifying gene family members into redundant and non-redundant gene pairs in model species where sufficient genetic and genomic data is available, such as Arabidopsis thaliana, the test case used here.

Results
Machine learning techniques that combine multiple attributes led to a dramatic improvement in predicting genetic redundancy over single trait classifiers alone, such as BLAST E-values or expression correlation. In withholding analysis, one of the methods used here, Support Vector Machines, was two-fold more precise than single attribute classifiers, reaching a level where the majority of redundant calls were correctly labeled. Using this higher confidence in identifying redundancy, machine learning predicts that about half of all genes in Arabidopsis showed the signature of predicted redundancy with at least one but typically less than three other family members. Interestingly, a large proportion of predicted redundant gene pairs were relatively old duplications (e.g., Ks > 1), suggesting that redundancy is stable over long evolutionary periods.

Conclusions
Machine learning predicts that most genes will have a functionally redundant paralog but will exhibit redundancy with relatively few genes within a family. The predictions and gene pair attributes for Arabidopsis provide a new resource for research in genetics and genome evolution. These techniques can now be applied to other organisms.