bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lumbar Disc Surgery: Results of the Prospective Lumbar Discectomy Study of the Joint Section on Disorders of the Spine and Peripheral Nerves of the American Association of Neurological Surgeons and the Congress of Neurological Surgeons
Authors: Abramovitz Joel N. , Neff Samuel R. 
Published: April 2011

Abstract
The Prospective Lumbar Discectomy Study enrolled 740 patients in a multiphysician, multicenter, consecutive patient protocol to evaluate the indications and efficacy of lumbar discectomy. Five hundred and thirteen patients could be evaluated at 3 months after surgery. Stepwise logistic regression showed that the factors of fraction of pain referred to the back, work-related injury, absence of back pain on straight leg-raise examination, correspondence of leg pain to typical radicular patterns, leg pain on straight leg-raise examination, and reflex asymmetry were independently predictive of good outcome from surgery. Univariate analysis of the cases with different numbers of predictive factors present showed that use of the operating microscope, sensory deficit, central disc bulge, and free disc fragment were correlated with outcome only in subgroups. An analysis of unsatisfactory outcomes showed two patterns: one of failure as a result of mechanical back pain and one of failure as a result of radiculopathy. Factors predictive of outcome did not influence the type of failure, In a stepwise logistic regression analysis, facetectomy and preoperative sensory deficit were associated with increased likelihood of mechanical back pain failure, while preoperative motor deficit was associated with an increased likelihood of radicular failure. The results support several intuitively derived and commonly believed principles of lumbar disc surgery.
Surgical Access to the Base of Skull and Upper Cervical Spine by Extended Maxillotomy
Authors: James David , Crockard Alan H. 
Published: April 2011

Abstract
An extended maxillotomy has been developed to permit wider surgical access to the base of the skull. It has proven particularly useful in the management of the previously untreatable neuraxial compression caused by basilar invagination in cases of osteogenesis imperfecta. In addition, patients with extensive extradural space-occupying lesions have been treated. The surgical technique is described and the results of its use in nine patients are presented.
Adaptation of Rigid Fixation to Cranial Flap Replacement
Authors: Smith Stewart C. , Pelofsky Stan 
Published: April 2011

Abstract
The use of titanium craniofacial plates and the principles of rigid fixation have been adapted to cranial flap replacement. The technique has been in use for more than 18 months with no complications related to the technique or implant. The advantages of using titanium screws and plates to achieve superior healing and cosmesis, as well as the reduction of postoperative artifacts on magnetic resonance imaging and computed tomographic scans, are of benefit to neurosurgical patients.
Infection of a Shunt by Mycobacterium fortuitum: Case Report
Authors: Chan Kwan-Hon , Mann Kirpal S. , Seto W. H. 
Published: April 2011

Abstract
Mycobacterium fortuitum is a rare cause of central nervous system infection: however, shunt infection caused by this organism has not been reported. We report a case of shunt infection subsequent to insertion of a ventriculoatrial shunt for obstructive hydrocephalus caused by a cerebellar hematoma. The shunt infection was controlled by removal of the shunt and a combination of systemic and intraventricular administration of amikacin, and oral administration of ofloxacin. The case is discussed and the pertinent literature reviewed.
Multiple Cerebral Angiomas and Rendu-Osler-Weber Disease: Case Report
Authors: Aesch B. , Lioret E. , de Toffol B. , Jan M. 
Published: April 2011

Abstract
A 25-year-old man was hospitalized after suffering a subarachnoid hemorrhage. Arteriograms disclosed two arteriovenous malformations, one of which was asymptomatic. Rendu-Osler-Weber disease was suspected because of the concomitant existence of cutaneous telangiectases, Review of the literature shows that in 12 previously published cases involving multiple arteriovenous malformations, this diagnosis was established five times. The indications for surgical treatment are discussed.
Low-Grade Astrocytoma of the Tectal Region as an Unusual Cause of Knee Pain: Case Report
Authors: Rutka James T. , George Richard E. , Davidson George , Hoffman Harold J. 
Published: April 2011

Abstract
A 12-year-old boy was investigated for knee pain and contractures, and was found to have an intraspinal tumor of a lumbar nerve root and a tumor in the tectal region, both low-grade astrocytomas, We postulated that the tectal region astrocytoma metastasized to the lumbar intraspinal region. After surgery, the child underwent focal irradiation to the posterior fossa supplemented by craniospinal irradiation and a boost dose to the region of the lumbar spinal tumor. A low-grade astrocytoma rarely presents as spinal metastasis. This case may represent the first of a primary tectal low-grade astrocytoma manifesting as a symptomatic spinal mass.
Desmoplastic Medulloblastoma Metastatic to the Pancreas: Case Report
Authors: Krouwer Hendrikus G.J. , Vollmerhausen John , White Joel , Prados Michael D. 
Published: April 2011

Abstract
A case is reported in which a desmoplastic medulloblastoma metastasized to the pancreas and to the surrounding soft tissues but did not recur locally or disseminate within the central nervous system. Multidrug chemotherapy and local radiation therapy resulted in a complete remission. In all four previously reported cases of medulloblastoma metastasizing to the pancreas, the diagnosis was not made until the postmortem examination, and all of these patients also had extensive metastases in other organ systems. Modification of the Weiss criteria defining extraneural metastases from tumors of the central nervous system is suggested.
Stereotactic Radiosurgery with the Cobalt-60 Gamma Unit in the Treatment of Growth Hormone-Producing Pituitary Tumors
Authors: Thorén Marja , Rähn Tiit , Wan-Yuo Guo , Sigbritt Werner 
Published: April 2011

Abstract
Stereotactic radiosurgery on the pituitary given with the cobalt-60 gamma unit was used in the treatment of 21 patients with growth hormone (GH)-producing pituitary adenomas and acromegaly. All but one patient had locally invasive macroadenomas, and in the majority of cases, there was parasellar growth. Radiosurgery was the initial treatment for seven patients. Fourteen patients were previously treated by pituitary surgery, eight of whom had undergone conventional external pituitary irradiation as well. All patients had clinical signs of active acromegaly before radiosurgery. The radiation doses given to the previously untreated patients or those who only underwent surgery were 40 to 70 Gy in each of one to three irradiations. The patients with previous external irradiation received a lower dose of 30 to 50 Gy in each of one or two irradiations. The patients were observed during a period of 1 to 21 years from the first radiosurgical session. Two young patients had a clinical remission with a substantial decline of GH levels to near normal serum profiles. Another eight patients obtained reduction of GH levels and clinical activity. More than half of the patients (11 of 21) had minor or no effects from the treatment. There were no complications from the radiosurgery except the development of pituitary insufficiency in 2 of 13 patients who did not undergo previous conventional external irradiation. The remission rates were lower than the results previously reported by us for radiosurgery for Cushing's disease. This may be a result of the predominance in the present study of invasive macroadenomas and single treatments and to the lower radiation doses used in the patients who underwent conventional irradiation previously. In the future, the effect of higher radiation doses will be evaluated. The presently available stereotactic magnetic resonance imaging with contrast enhancement, which improves the visualization of the target volume, may aid in improving future radiosurgical results in the treatment of GH-producing pituitary tumors.
Isolated Lesion of the Axillary Nerve: Surgical Treatment and Outcome in 12 Cases
Authors: Nucci Francesco , Ramundo Epimenio Orlando , D'Andrea Vito , Salvati Maurizio , Artico Marco 
Published: April 2011

Abstract
We report a series of 12 cases of isolated lesions of the axillary nerve treated surgically. We discuss the pathogenesis, clinical pattern, and surgical treatment of this lesion together with the results obtained.
Radiolucent Osteoma of the Skull: Case Report
Authors: Shibata Yasushi , Yoshii Yoshihiko , Tsukada Atsuro , Nose Tadao 
Published: April 2011

Abstract
A rare case of a radiolucent osteoma of the skull is reported. The radiological and pathological findings of this lesion, including magnetic resonance imaging findings, are presented, and the efficacy of magnetic resonance imaging for the diagnosis of this skull tumor is evaluated. The differential diagnosis of radiolucent bone tumors is discussed.
Neurological Features of Cranial Vault Lymphomas: Report of Two Cases
Authors: Herkes Geoffrey K. , Partington Michael D. , O'Neill Brian P. 
Published: April 2011

Abstract
Two patients who had focal neurological deficits as the initial manifestation of a malignant non-Hodgkin's lymphoma involving the skull are described. Soft-tissue masses and variable bone destruction were the predominant computed tomographic findings, and magnetic resonance imaging studies revealed meningeal involvement in one case and sinus thrombosis in the other. Malignant non-Hodgkin's lymphomas initially appearing in the skull are rare, but these lesions should be considered in patients with a palpable scalp mass who have focal neurological signs.
Cerebral Metastasis from an Epithelioid Malignant Schwannoma: Case Report
Authors: D'Angelo Vincenzo , Casadei Gianpiero , Bizzozero Luigi 
Published: April 2011

Abstract
The authors present a case of brain metastasis from an epithelioid malignant schwannoma. The patient previously had undergone a surgical resection of the primary tumor in the right forearm. The neoplasm was composed of nests of cells with an entirely epithelioid appearance without spindle cell areas. Immunohistochemically, the tumor cells stained positive for S100 protein and negative for cytokeratin, neuron-specific enolase, and anti-melanoma antiserum. To our knowledge, this is the first reported case of cerebral metastasis from an epithelioid malignant tumor of the peripheral nerve sheath.
Marked Growth of a Cerebral Arteriovenous Malformation: Case Report and Review of the Literature
Authors: Wakabayashi Shin-ichi , Ohno Kikuo , Shishido Tsuneo , Tamaki Masashi , Matsushima Yoshiharu , Hirakawa Kimiyoshi 
Published: April 2011

Abstract
A case demonstrating the marked growth of an angiographically occult arteriovenous malformation is presented. A review of 58 cases in which an increase in the size of an arteriovenous malformation occurred suggested that the patient's initial age may have had an important role in such growth and that both the age and the duration of follow-up were related to the extent of growth. Follow-up neuroradiological examinations are thought to be necessary for patients who have had an episode of intracranial hemorrhage of unknown cause during childhood, even if the initial angiograms revealed no vascular lesion.
Technical note
Authors: Huhn Stephen L. , Wolf Aizik L. , Ecklund James 
Published: April 2011

Abstract
Cervical instability secondary to fracture/dislocation or traumatic subluxation involving the posterior elements may be treated by a variety of fusion techniques. The rigidity of the stainless steel wires used in posterior cervical fusions often leads to difficulty with insertion, adequate tension, and conformation of the graft construct. This report describes a technique of posterior cervical fusion employing a wire system using flexible stainless steel cables. The wire consists of a flexible, 49-strand, stainless steel cable connected on one end to a short, malleable, blunt leader with the opposite end connected to a small islet. The cable may be used in occipitocervical, atlantoaxial, facet-to-spinous process, and interspinous fusion techniques. The cable loop is secured by using a tension/crimper device that sets the desired tension in the cable. In addition to superior biomechanical strength, the flexibility of the cable allows greater ease of insertion and tension adjustment. In terms of direct operative instrumentation in posterior cervical arthrodesis, involving both the upper and lower cervical spine, the cable system appears to be a safe and efficient alternative to monofilament wires.
The Metabotropic Glutamate Receptor Activates the Lipid Kinase PI3K in Drosophila Motor Neurons Through the Calcium/Calmodulin-Dependent Protein Kinase II and the Nonreceptor Tyrosine Protein Kinase DFak
Authors: Chun-Jen Lin Curtis , Summerville James B , Howlett Eric , Stern Michael 
Published: April 2011

Abstract
Ligand activation of the metabotropic glutamate receptor (mGluR) activates the lipid kinase PI3K in both the mammalian central nervous system and Drosophila motor nerve terminal. In several subregions of the mammalian brain, mGluR-mediated PI3K activation is essential for a form of synaptic plasticity termed long-term depression (LTD), which is implicated in neurological diseases such as fragile X and autism. In Drosophila larval motor neurons, ligand activation of DmGluRA, the sole Drosophila mGluR, similarly mediates a PI3K-dependent downregulation of neuronal activity. The mechanism by which mGluR activates PI3K remains incompletely understood in either mammals or Drosophila. Here we identify CaMKII and the nonreceptor tyrosine kinase DFak as critical intermediates in the DmGluRA-dependent activation of PI3K at Drosophila motor nerve terminals. We find that transgene-induced CaMKII inhibition or the DFakCG1 null mutation each block the ability of glutamate application to activate PI3K in larval motor nerve terminals, whereas transgene-induced CaMKII activation increases PI3K activity in motor nerve terminals in a DFak-dependent manner, even in the absence of glutamate application. We also find that CaMKII activation induces other PI3K-dependent effects, such as increased motor axon diameter and increased synapse number at the larval neuromuscular junction. CaMKII, but not PI3K, requires DFak activity for these increases. We conclude that the activation of PI3K by DmGluRA is mediated by CaMKII and DFak.
Incidence of Diabetes Following Ramipril or Rosiglitazone Withdrawal
Authors:   The DREAM Trial Investigators
Published: April 2011

OBJECTIVE
To examine the impact of withdrawing rosiglitazone and ramipril medication on diabetes incidence after closeout of the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) trial.

RESEARCH DESIGN AND METHODS
The 3,366 DREAM subjects at trial end who had not developed diabetes while taking double-blind study medication were transferred to single-blind placebo for 2 to 3 months before undergoing an oral glucose tolerance test. Glycemic status was analyzed for the trial plus washout period and for the washout period alone.

RESULTS
Following median (interquartile range) 71 (63–86) days drug withdrawal, overall glycemic status remained modestly improved in those allocated ramipril during the trial with an 11% increase in regression to normoglycemia, compared with placebo. In those previously allocated rosiglitazone, glycemic status remained substantially improved with a 49% reduction of new-onset diabetes or death and a 22% increase in regression to normoglycemia, compared with placebo. However, during the washout phase alone the incidence of diabetes or death was identical for those allocated previously to ramipril or placebo, or to rosiglitazone or placebo.

CONCLUSIONS
In people allocated to ramipril compared with those not allocated ramipril during the trial, the postwashout normoglycemia incidence was higher. In people allocated to rosiglitazone compared with those not allocated rosiglitazone during the trial, the postwashout incidence of diabetes was significantly lower and the incidence of normoglycemia was higher. During the washout period, diabetes incidence was the same for ramipril versus placebo and for rosiglitazone versus placebo. Rosiglitazone delays disease progression during treatment but the process resumes at the placebo rate when the drug is stopped.
3.5 SUPPRESSION OF SPRUCE BUDWORM POPULATIONS BY TRICHOGRAMMA MINUTUM RILEY, 1982–1986
Authors: Smith S.M. , Wallace D.R. , Howse G. , Meating J. 
Published: April 2011

AbstractThe ability of the egg parasitoid, Trichogramma minutum Riley, to suppress outbreak populations of the spruce budworm, Choristoneura fumiferana (Clemens), was studied annually near Hearst, Ont., from 1982 through 1986. Timing of broadcast parasitoid-releases was linked to spruce budworm moth emergence and oviposition. These phenological relationships were predicted from a regression based on larval development at least 2 weeks before expected emergence; this allowed sufficient time to regulate (program) parasitoid emergence during mass-rearing. Emergence of caged spruce budworm adults was used to monitor moth eclosion in the field. Pheromone traps provided daily information on the activity of male moths and helped to synchronize the parasitoid releases with spruce budworm oviposition. Information on parasitoid activity was obtained from sentinel (laboratory-reared) and naturally occurring spruce budworm egg masses. A curvilinear relationship between the rate of parasitoid release and parasitism of sentinel egg masses was developed. Two parasitoid releases, 1 week apart, early in the oviposition period of spruce budworm, significantly increased parasitism of host eggs by 14–83% and reduced larval populations correspondingly from 42 to 82%. Single releases were less effective and increased parasitism by 0.3–52% (single ground release, 1986). Two parasitoid releases, combined with a spring application of Bacillus thuringiensis Berliner to larval populations, was the most effective strategy and resulted in 83% egg parasitism and 93% larval reduction. Release rates greater than 12–16 × 106 ♀ ♀ T. minutum per hectare were not warranted based on impact and costs. The effects of release timing, weather, host density, and parasitoid quality on the future successful use of T. minutum are discussed.
A REVISION OF THE GENERA MYCETOPORUS MANNERHEIM AND ISCHNOSOMA STEPHENS (COLEOPTERA: STAPHYLINIDAE: TACHYPORINAE) OF NORTH AND CENTRAL AMERICA
Authors: Campbell J.M. 
Published: April 2011

AbstractThe North and Central American species formerly placed in the genus Mycetoporus are revised. Two genera are recognized, Mycetoporus Mannerheim and Ischnosoma Stephens, each with 18 species. The morphological and historical basis for this division is discussed. Ten species of Mycetoporus are described as new: bipunctatu, floridensis, impunctatus, neomexicanus, nidicola, pacificus, rufohumeralis, segregatus, smetanai, and triangulatus. Ten species of Ischnosoma are described as new: arizonense, ashei, costale, durangoense, fimbriatum, hermani, lecontei, mexicanum, pecki, and suteri. Mycetoporus boreelus J. Sahlberg, a species restricted to the Palearctic region, is removed from synonymy with M. nigrans Mäklin and Mycetoporus insignis Mäklin is found to be a junior synonym of M. americanus Erichson. Mycetoporus discalis, M. punctatissimus, and M. punctulatus, all species described by Hatch (1957), are transferred to the genus Bryoporus subgenus Bryophacis and the name Tachinus humidus Say is treated as a nomen dubium in the genus Mycetoporus.The usage of the generic names Mycetoporus Mannerheim and Ischnosoma Stephens is discussed. The North American species of the genus Mycetoporus are placed in six species groups and those of the genus Ischnosoma are placed in four species groups.A neotype is designated for Mycetoporus nigrans Mäklin and lectotypes are designated for M. americanus Erichson, M. insignis Mäklin, M. tenuis Horn, M. lucidulus LeConte, M. consors LeConte, Ischnosoma pictum (Horn) and I. flavicolle (LeConte). The following species were transferred from Mycetoporus to Ischnosoma and are new combinations: pictum Horn, splendidum Gravenhorst, flavicolle LeConte, virginiense Bernhauer, coxale Sharp, hospitale Fall, californicum Bernhauer and Schubert, and curtipenne Bernhauer.All genera, species groups, and species are described and the species are illustrated with line drawings and scanning electron photomicrographs. Keys are provided to distinguish the genera Mycetoporus and Ischnosoma and for all the species in each genus. The New World distribution of each species is mapped. The biology of each species, if known, is discussed.
Gp130-Dependent Astrocytic Survival Is Critical for the Control of Autoimmune Central Nervous System Inflammation
Authors: Haroon Fahad , Drögemüller Katrin , Händel Ulrike , Brunn Anna , Reinhold Dirk , Nishanth Gopala , Mueller Werner , Trautwein Christian , Ernst Matthias , Deckert Martina , Schlüter Dirk 
Published: April 2011

Abstract
Astrocytes are activated in experimental autoimmune encephalomyelitis (EAE) and have been suggested to either aggravate or ameliorate EAE. However, the mechanisms leading to an adverse or protective effect of astrocytes on the course of EAE are incompletely understood. To gain insight into the astrocyte-specific function of gp130 in EAE, we immunized mice lacking cell surface expression of gp130, the signal-transducing receptor for cytokines of the IL-6 family, with myelin oligodendrocyte glycoprotein35–55 peptide. These glial fibrillary acid protein (GFAP)-Cre gp130fl/fl mice developed clinically a significantly more severe EAE than control mice and succumbed to chronic EAE. Loss of astrocytic gp130 expression resulted in apoptosis of astrocytes in inflammatory lesions of GFAP-Cre gp130fl/fl mice, whereas gp130fl/fl control mice developed astrogliosis. Astrocyte loss of GFAP-Cre gp130fl/fl mice was paralleled by significantly larger areas of demyelination and significantly increased numbers of CD4 T cells in the CNS. Additionally, loss of astrocytes in GFAP-Cre gp130fl/fl mice resulted in a reduction of CNS regulatory Foxp3+ CD4 T cells and an increase of IL-17–, IFN-γ–, and TNF-producing CD4 as well as IFN-γ– and TNF-producing CD8 T cells, illustrating that astrocytes regulate the phenotypic composition of T cells. An analysis of mice deficient in either astrocytic gp130– Src homology region 2 domain-containing phosphatase 2/Ras/ERK or gp130–STAT1/3 signaling revealed that prevention of astrocyte apoptosis, restriction of demyelination, and T cell infiltration were dependent on the astrocytic gp130–Src homology region 2 domain-containing phosphatase 2/Ras/ERK, but not on the gp130–STAT1/3 pathway, further demonstrating that gp130-dependent astrocyte activation is crucial to ameliorate EAE.