bluuebunny/crossref_metadata_2025_split huggingface dataset:
Personality changes related to presence and treatment of substance use (disorders): a systematic review
Authors: Juchem Christina M. , Bendau Antonia , Bandurski Leonie C. , Reich Nico J. , Baumgardt Saskia , Asselmann Eva 
Published: April 2024

AbstractHeavy substance use (SU) and substance use disorders (SUD) have complex etiologies and often severe consequences. Certain personality traits have been associated with an increased risk for SU(D), but far less is known about personality changes related to SU(D). This review aims to synthesize the existing literature on this research question. A systematic literature search was conducted from November 2022 to February 2023 in PubMed, EbscoHost, and Web of Science. Peer-reviewed original papers on SU(D)-related personality changes were included. Of 55 included studies, 38 were observational population-based studies and 17 were intervention studies. Overall, personality and SU measures, samples, study designs, and statistical approaches were highly heterogenous. In observational studies, higher SU was most consistently related to increases in impulsivity-related traits and (less so) neuroticism, while interventions in the context of SU(D) were mostly associated with increases in conscientiousness and self-efficacy and lasting decreases in neuroticism. Findings for traits related to extraversion, openness, conscientiousness, and agreeableness were mixed and depended on SU measure and age. Studies on bidirectional associations suggest that personality and SU(D) both influence each other over time. Due to their strong association with SU(D), impulsivity-related traits may be important target points for interventions. Future work may investigate the mechanisms underlying personality changes related to SU(D), distinguishing substance-specific effects from general SU(D)-related processes like withdrawal, craving, and loss of control. Furthermore, more research is needed to examine whether SU(D)-related personality changes vary by developmental stage and clinical features (e.g. initial use, onset, remission, and relapse).
The Committee on the Rights of the Child and Article 12: Applying the Lundy model to treaty body recommendations
Authors: Molloy Sean 
Published: April 2024

AbstractArticle 12 of the United Nations (UN) Convention on the Rights of the Child (CRC) requires that states afford children the opportunity, subject to certain qualifications, to express their views on all matters that affect them. Alongside the substantive, procedural and normative significance of this right, Article 12 both reflects and contributes to progressive understandings of childhood more generally; it recognizes children as agentic beings ‘with integrity and personality and the ability to participate freely in society and articulate a view’. Nevertheless, the fulfilment of this legal right is often not realized, requiring ongoing efforts to help translate it into practice. This article examines how the UN Committee on the Rights of the Child (CommCRC), through recommendations to state parties issued as part of its monitoring function, can assist, or hinder the realization of Article 12. The primary argument advanced is that when issuing recommendations, the CommCRC ought to draw on the Lundy Model of Child Participation as an organizing concept- one utilized to weave together the substance of their recommendations in ways more instructive, useful, and impactful than the current approach.
‘Chile – Ballad of the Cameraman’: New Song and ‘Revolutionary’ South America in Wolf Biermann's Anthems of East German Critical Solidarity
Authors: CARLSON JULIUS REDER 
Published: April 2024

AbstractUsing GDR dissident singer-songwriter Wolf Biermann's ‘Chile – Ballade vom Kameramann’ as a point of departure, this article explores the role that ‘revolutionary’ South America and its musical corollary, the Nueva Canción, played in expressions of inner-communist critique in 1970s East Germany. Biermann's critique was Janus-faced. Lyrically, the ‘Chilean’ allegory of his ballad, in which a cameraman is murdered by a soldier, expressed support for the Allende administration while simultaneously destabilizing Soviet Bloc rhetoric. Musically, references to Nueva Canción music such as that of singer-songwriter Daniel Viglietti represented the anti-imperialist Other while simultaneously rejecting GDR-style socialist realism. On the one hand, Biermann's inspiration in South America can be heard as a colonizing gesture; on the other, it can be understood to reflect a provincialized East German society looking to the Third World for alternative sociopolitical – and musical – models.
A Model for Thaw and Erosion of Permafrost Riverbanks
Authors: Douglas Madison M. , Lamb Michael P. 
Published: April 2024

AbstractHow will bank erosion rates in Arctic rivers respond to a warming climate? Existing physical models predict that bank erosion rates should increase with water temperature as permafrost thaws more rapidly. However, the same theory predicts much faster erosion than is typically observed. We propose that these models are missing a key component: a layer of thawed sediment on the bank that buffers heat transfer and slows erosion. We developed a 1D model for this thawed layer, which reveals three regimes for permafrost riverbank erosion. Thaw‐limited erosion occurs in the absence of a thawed layer, such that rapid pore‐ice melting sets the pace of erosion, consistent with existing models. Entrainment‐limited erosion occurs when pore‐ice melting outpaces bank erosion, resulting in a thawed layer, and the relatively slow entrainment of sediment sets the pace of erosion similar to non‐permafrost rivers. Third, the intermediate regime occurs when the thawed layer goes through cycles of thickening and failure, leading to a transient thermal buffer that slows thaw rates. Distinguishing between these regimes is important because thaw‐limited erosion is highly sensitive to water temperature, whereas entrainment‐limited erosion is not. Interestingly, the buffered regime produces a thawed layer and relatively slow erosion rates like the entrainment‐limited regime, but erosion rates are temperature sensitive like the thaw‐limited regime. The results suggest the potential for accelerating erosion in a warming Arctic where bank erosion is presently thaw‐limited or buffered. Moreover, rivers can experience all regimes annually and transition between regimes with warming, altering their sensitivity to climate change.
Cell death as an architect of adult skin stem cell niches
Authors: Lecomte Kim , Toniolo Annagiada , Hoste Esther 
Published: April 2024

AbstractOur skin provides a physical and immunological barrier against dehydration and environmental insults ranging from microbial attacks, toxins and UV irradiation to wounding. Proper functioning of the skin barrier largely depends on the interplay between keratinocytes- the epithelial cells of the skin- and immune cells. Two spatially distinct populations of keratinocyte stem cells (SCs) maintain the epidermal barrier function and the hair follicle. These SCs are inherently long-lived, but cell death can occur within their niches and impacts their functionality. The default cell death programme in skin is apoptosis, an orderly and non-inflammatory suicide programme. However, recent findings are shedding light on the significance of various modes of regulated necrotic cell death, which are lytic and can provoke inflammation within the local skin environment. While the presence of dying cells was generally regarded as a mere consequence of inflammation, findings in various human dermatological conditions and experimental mouse models of aberrant cell death control demonstrated that cell death programmes in keratinocytes (KCs) can drive skin inflammation and even tumour initiation. When cells die, they need to be removed by phagocytosis and KCs can function as non-professional phagocytes of apoptotic cells with important implications for their SC capacities. It is becoming apparent that in conditions of heightened SC activity, distinct cell death modalities differentially impact the different skin SC populations in their local niches. Here, we describe how regulated cell death modalities functionally affect epidermal SC niches along with their relevance to injury repair, inflammatory skin disorders and cancer.
A dataset of storm surge reconstructions in the Western North Pacific using CNN
Authors: Dang Wen , Feng Jianlong , Li Delei , Fan Mengzhen , Zhao Liang 
Published: April 2024

AbstractThe relatively short duration of available tide gauge records poses challenges for conducting comprehensive statistical analyses of storm surges in the Western North Pacific. To address this issue, we employ a convolutional neural network model to reconstruct the maximum daily storm surge at 160 tide gauges from 1900 to 2010 in the Western North Pacific. The reconstructed dataset serves multiple purposes. Firstly, it facilitates the identification of regions where notable changes in the storm surges have occurred in the past. Additionally, the dataset enables long-term analyses of the storm surge climate, offering insights into historical patterns and variations. Furthermore, it provides a solid foundation for conducting robust extreme value analyses. To ensure accessibility, the data are publicly available through a repository, allowing for easy access and utilization by the broader scientific community and the general public. Overall, our research contributes to the field of oceanography by providing a dataset that aids in understanding the historical storm surge dynamics in the Western North Pacific region.
Efficiency assessment of a novel automatic mosquito pupae sex separation system in support of area-wide male-based release strategies
Authors: Mamai W. , Bueno-Masso O. , Wallner T. , Nikièma S. A. , Meletiou S. , Deng L. , Balestrino F. , Yamada H. , Bouyer J. 
Published: April 2024

AbstractThis study provides a comparative analysis of two state-of-the-art automatic mosquito pupae sex sorters currently available: the ORINNO and the WOLBAKI Biotech pupae sex separation systems, which both exploit the sexual size dimorphism of pupae. In Aedes aegypti, the WOLBAKI sex sorter and the ORINNO with a sieve mesh size of 1.050 mm achieved sex separation with female contamination rates below 1%, low pupae mortality rates and high male flight capacity. However, in Ae. albopictus, there was more variability, with female contamination rates above the 1% threshold and pupae mortality reaching 27% when using the ORINNO sorter. On the other hand, the WOLBAKI sorter achieved a male pupae recovery of 47.99 ± 8.81% and 50.91 ± 11.77% in Ae. aegypti and Ae. albopictus, respectively, while the ORINNO sorter with a smaller sieve size achieved male pupae recoveries of 38.08 ± 9.69% and 40.16 ± 2.73% in Ae. aegypti and Ae. albopictus, respectively. This study provides valuable information for researchers and practitioners in the field, assisting in the selection of the most suitable system for mosquito control, management and research programs depending on their specific requirements.
The Arabic EAT-10 and FEES in dysphagia screening among cancer patients: a comparative prospective study
Authors: Abdel-Hay Da’ad , Abdelhay Osama , Ghatasheh Hamza A. , Al-Jarrah Sameer , Eid Suhaib , Al Tamimi Mutaz A. , Al-Mayata Ibrahim 
Published: April 2024

AbstractHead and neck cancer treatments, such as radiotherapy, chemotherapy, and surgery, have diverse effects on patients, leading to dysphagia as a significant post-treatment issue. This study aims to evaluate the effectiveness of the Arabic version of the EAT-10 screening instrument (A-EAT-10) using Fiber-Optic Endoscopic Evaluation of Swallowing (FEES) as an imperfect gold standard. Additionally, we seek to establish a correlation between A-EAT-10 and PEG tube insertion in head and neck cancer (HNC) patients. Our sample comprised 130 head and neck cancer patients with varying cancer types at King Hussein Cancer Center (KHCC). We followed these patients throughout their distinct treatment plans up to one month after their final treatment session. During follow-up visits, we administered the A-Eat-10 instrument to monitor dysphagia. FEES were conducted at the initial and concluding visits to compare results with A-EAT-10 scores. The results in our tests, assuming independence or dependence, demonstrated excellent agreement. A-EAT-10 exhibited outstanding predictive capabilities with an AUC ranging from 93 to 97%. A-EAT-10 tended to slightly overestimate dysphagia at later treatment stages by approximately 20% compared to FEES, with an RR of 1.2 (95% CI 0.91, 1.56, p-value = 0.21), indicating statistical insignificance. In conclusion, A-EAT-10 is an excellent option for dysphagia evaluation, offering non-invasive, straightforward, and cost-effective advantages compared to FEES. Its utility extends to predicting the need for PEG tube insertion at initial patient visits, making it a valuable tool for informed treatment decisions. Notably, A-EAT-10 demonstrates a diminishing correlation with FEES over time.
Optimization of wear parameters for ECAP-processed ZK30 alloy using response surface and machine learning approaches: a comparative study
Authors: Shaban Mahmoud , Alsunaydih Fahad Nasser , Kouta Hanan , El-Sanabary Samar , Alrumayh Abdulrahman , Alateyah Abdulrahman I. , Alawad Majed O. , El-Garaihy Waleed H. , El-Taybany Yasmine 
Published: April 2024

AbstractThe present research applies different statistical analysis and machine learning (ML) approaches to predict and optimize the processing parameters on the wear behavior of ZK30 alloy processed through equal channel angular pressing (ECAP) technique. Firstly, The ECAPed ZK30 billets have been examined at as-annealed (AA), 1-pass, and 4-passes of route Bc (4Bc). Then, the wear output responses in terms of volume loss (VL) and coefficient of friction (COF) have been experimentally investigated by varying load pressure (P) and speed (V) using design of experiments (DOE). In the second step, statistical analysis of variance (ANOVA), 3D response surface plots, and ML have been employed to predict the output responses. Subsequently, genetic algorithm (GA), hybrid DOE–GA, and multi-objective genetic algorithm techniques have been used to optimize the input variables. The experimental results of ECAP process reveal a significant reduction in the average grain size by 92.7% as it processed through 4Bc compared to AA counterpart. Furthermore, 4Bc exhibited a significant improvement in the VL by 99.8% compared to AA counterpart. Both regression and ML prediction models establish a significant correlation between the projected and the actual data, indicating that the experimental and predicted values agreed exceptionally well. The minimal VL at different ECAP passes was obtained at the highest condition of the wear test. Also, the minimal COF for all ECAP passes was obtained at maximum wear load. However, the optimal speed in the wear process decreased with the number of billets passes for minimum COF. The validation of predicted ML models and VL regression under different wear conditions have an accuracy range of 70–99.7%, respectively.
Acute interval running induces greater excess post-exercise oxygen consumption and lipid oxidation than isocaloric continuous running in men with obesity
Authors: Jiang Lang , Zhang Yihong , Wang Zhengzhen , Wang Yan 
Published: April 2024

AbstractStudies seem to show that high-intensity interval training (HIIT) is a more time-efficient protocol for weight loss, compared with moderate-intensity continuous training (MICT). Our aim was to compare the acute effects of energy expenditure (EE) matched HIIT vs. MICT on excess post-exercise oxygen consumption (EPOC) and substrate metabolism in male college students with obesity. Twenty-one untrained male college students (age, 22 ± 3 years; body fat, 28.4 ± 4.5%) completed two acute interventions (~ 300 kcal) on a treadmill in a randomized order: (1) HIIT: 3 min bouts at 90% of maximal oxygen uptake (VO2max) with 2 min of recovery at 25% of VO2max; (2) MICT: 60% of VO2max continuous training. EPOC and substrate metabolism were measured by indirect calorimetry during and 30 min after exercise. Results showed that EPOC was higher after HIIT (66.20 ± 14.36 kcal) compared to MICT (53.91 ± 12.63 kcal, p = 0.045), especially in the first 10 min after exercise (HIIT: 45.91 ± 9.64 kcal and MICT: 34.39 ± 7.22 kcal, p = 0.041). Lipid oxidation rate was higher after HIIT (1.01 ± 0.43 mg/kg/min) compared to MICT (0.76 ± 0.46 mg/kg/min, p = 0.003). Moreover, the percentage of energy from lipid was higher after HIIT (37.94 ± 14.21%) compared to MICT (30.09 ± 13.54%, p = 0.020). We conclude that HIIT results in greater total EE and EPOC, as well as higher percentage of energy from lipid during EPOC than EE matched MICT in male college students with obesity.
HBCVTr: an end-to-end transformer with a deep neural network hybrid model for anti-HBV and HCV activity predictor from SMILES
Authors: Meewan Ittipat , Panmanee Jiraporn , Petchyam Nopphon , Lertvilai Pichaya 
Published: April 2024

AbstractHepatitis B and C viruses (HBV and HCV) are significant causes of chronic liver diseases, with approximately 350 million infections globally. To accelerate the finding of effective treatment options, we introduce HBCVTr, a novel ligand-based drug design (LBDD) method for predicting the inhibitory activity of small molecules against HBV and HCV. HBCVTr employs a hybrid model consisting of double encoders of transformers and a deep neural network to learn the relationship between small molecules’ simplified molecular-input line-entry system (SMILES) and their antiviral activity against HBV or HCV. The prediction accuracy of HBCVTr has surpassed baseline machine learning models and existing methods, with R-squared values of 0.641 and 0.721 for the HBV and HCV test sets, respectively. The trained models were successfully applied to virtual screening against 10 million compounds within 240 h, leading to the discovery of the top novel inhibitor candidates, including IJN04 for HBV and IJN12 and IJN19 for HCV. Molecular docking and dynamics simulations identified IJN04, IJN12, and IJN19 target proteins as the HBV core antigen, HCV NS5B RNA-dependent RNA polymerase, and HCV NS3/4A serine protease, respectively. Overall, HBCVTr offers a new and rapid drug discovery and development screening method targeting HBV and HCV.
Neoadjuvant radiochemotherapy is safe and feasible for breast conserving surgery or immediate reconstruction
Authors: Yuan Jingjing , Zhang Meilin , Wang Maoli , Zhang Mingdi , Wu Kejin , Chen Hongliang 
Published: April 2024

AbstractThis study aimed to evaluate the survival outcomes of neoadjuvant radiochemotherapy (NARCT) for early breast cancer. Female patients ≤ 80 years old with unilateral T1-T4 invasive ductal breast cancer treated with neoadjuvant chemotherapy (NAC) and radiation therapy (RT) between 2006 and 2015 were enrolled from SEER database. Baseline differences in clinical and pathological characteristics were evaluated using chi-square test. The survival outcomes were estimated by Kaplan–Meier analysis and compared using Cox hazards models. The effects of baseline differences on survival outcome in patients treated with neoadjuvant radiation therapy (NART) and post-operation radiation therapy (PORT) were circumvented by propensity score matching (PSM). Altogether 14,151 patients receiving NAC and RT were enrolled, among whom 386 underwent NART. Based on a 1:4 PSM cohort, NART was an independent unfavorable prognostic factor for breast cancer-specific survival (BCSS) and overall survival (OS) for the whole cohort. However, among patients receiving breast conserving surgery (BCS) (HR 1.029, P = 0.915 for BCSS; HR 1.003, P = 0.990 for OS) or implant-based immediate breast reconstruction (IBR) (HR 1.039, P = 0.921 for BCSS; HR 1.153, P = 0.697 for OS), those treated with NART had similar survival outcomes compared with patients treated with PORT. In conclusion, NARCT was a safe and feasible approach for patients undergoing BCS and IBR.
A new method for unmanned aerial vehicle path planning in complex environments
Authors: He Yong , Hou Ticheng , Wang Mingran 
Published: April 2024

AbstractTo solve the problems of UAV path planning, such as low search efficiency, uneven path, and inability to adapt to unknown environments, this paper proposes A double-layer optimization A* and dynamic window method for UAV path planning. Firstly, the neighboring node clip-off rule is defined to optimize the node expansion mode of the A* algorithm, and the obstacle coverage model is designed to dynamically adjust the heurizing function of the A* algorithm to improve the path search efficiency. Then, the Bresenham algorithm is adopted for collision detection and critical path nodes are extracted to significantly reduce the number of path turning points. Secondly, a new tracking index is proposed to optimize the evaluation function of the dynamic window method to make the local path fit the global path further. By detecting the dangerous distance, the dynamic adaptive method of evaluation function weight is designed to improve the fixed weight of the dynamic window method. Finally, the key turning point of optimizing the A* algorithm is taken as the temporary target point to improve the DWA algorithm, and the local part follows the global part, and the fusion of the two algorithms is realized. Simulation results show that the proposed method can significantly improve the efficiency and smoothness of mobile robot path planning, enhance the real-time obstacle avoidance and adaptive ability of unknown environments, and better meet the requirements of complex planning tasks.
Salience network connectivity is altered in 6-week-old infants at heightened likelihood for developing autism
Authors: Tsang Tawny , Green Shulamite A. , Liu Janelle , Lawrence Katherine , Jeste Shafali , Bookheimer Susan Y. , Dapretto Mirella 
Published: April 2024

AbstractConverging evidence implicates disrupted brain connectivity in autism spectrum disorder (ASD); however, the mechanisms linking altered connectivity early in development to the emergence of ASD symptomatology remain poorly understood. Here we examined whether atypicalities in the Salience Network – an early-emerging neural network involved in orienting attention to the most salient aspects of one’s internal and external environment – may predict the development of ASD symptoms such as reduced social attention and atypical sensory processing. Six-week-old infants at high likelihood of developing ASD based on family history exhibited stronger Salience Network connectivity with sensorimotor regions; infants at typical likelihood of developing ASD demonstrated stronger Salience Network connectivity with prefrontal regions involved in social attention. Infants with higher connectivity with sensorimotor regions had lower connectivity with prefrontal regions, suggesting a direct tradeoff between attention to basic sensory versus socially-relevant information. Early alterations in Salience Network connectivity predicted subsequent ASD symptomatology, providing a plausible mechanistic account for the unfolding of atypical developmental trajectories associated with vulnerability to ASD.