bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum Pepsinogens and Helicobacter pylori in Relation to the Risk of Esophageal Squamous Cell Carcinoma in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study
Authors: Cook Michael B. , Dawsey Sanford M. , Diaw Lena , Blaser Martin J. , Perez-Perez Guillermo I. , Abnet Christian C. , Taylor Philip R. , Albanes Demetrius , Virtamo Jarmo , Kamangar Farin 
Published: August 2010

Abstract
Background: Helicobacter pylori can induce gastric atrophy in humans, which in turn increases gastric cancer risk. Whether H. pylori and gastric atrophy also affect the risk of esophageal squamous cell carcinoma (ESCC), however, remains unresolved.
Methods: We performed a nested case-control study within the prospective Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study to assess these relationships. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study is composed of 29,133 Finnish male smokers, ages 50 to 69 years, who were recruited during 1985-1988. Using baseline sera, we assessed H. pylori status (via immunoglobulin G antibodies against whole-cell and CagA antigens) and gastric atrophy status [via the biomarkers pepsinogen I (PGI) and pepsinogen II (PGII)] in 79 ESCC cases and 94 controls. Logistic regression with adjustment for age, date of blood draw, education, cigarette smoking, alcohol, body mass index, and fruit and vegetable intake was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI).
Results: Gastric atrophy (PGI/PGII &lt;4) was associated with ESCC (OR, 4.58; 95% CI, 2.00-10.48). There was no evidence for an association between H. pylori and ESCC (OR, 0.94; 95% CI, 0.40-2.24).
Conclusions: These results could be explained by misclassification of H. pylori status due to serologic amnesia, ESCC risk being dependent on the functional consequences or interactions of H. pylori rather than the infection per se, gastric atrophy having a different histogenesis in ESCC without being primarily dependent on H. pylori acquisition, or a lack of statistical power to detect an effect.
Impact: Validation of these results may warrant mechanistic studies to determine the route of association between gastric atrophy and ESCC. Cancer Epidemiol Biomarkers Prev; 19(8); 1966–75. ©2010 AACR.
Serum Free Circulating DNA Is a Useful Biomarker to Distinguish Benign versus Malignant Prostate Disease
Authors: Gordian Edna , Ramachandran Kavitha , Reis Isildinha M. , Manoharan Murugesan , Soloway Mark S. , Singal Rakesh 
Published: August 2010

Abstract
Background: Free circulating DNA (fcDNA) has been shown to be elevated in serum of prostate cancer patients compared with benign controls. However, studies evaluating the role of fcDNA as a biomarker in a “representative” patient group who have undergone prostate cancer screening are lacking. Our study examined the use of serum fcDNA levels as a biomarker of prostate cancer in such a setting.
Methods: The study included 252 men, with prostate-specific antigen (PSA) levels &gt;4 ng/mL and/or abnormal digital rectal exam. fcDNA levels in serum before prostate biopsy were quantitated by real-time PCR amplification of the glutathione S-transferase, pi, gene.
Results: Patients with PSA ≤ 10 ng/mL with fcDNA &gt; 180 ng/mL were at increased risk for prostate cancer compared with those with fcDNA ≤180 ng/mL (odds ratio, 4.27; 95% confidence interval, 2.05-8.88; P &lt; 0.001; area under the curve, 0.742). The multivariate model including age, race, PSA, fcDNA, and interaction between fcDNA and PSA yielded a high negative predictive value of 93.1% and increased specificity of 33.1% compared with negative predictive value of 73.3% and specificity of 6.7% in the model excluding fcDNA.
Conclusions: Our results indicate that fcDNA may improve the specificity of prostate cancer screening.
Impact: Our study shows that adding fcDNA to prostate cancer screening can reduce the number of unnecessary prostate biopsies. Cancer Epidemiol Biomarkers Prev; 19(8); 1984–91. ©2010 AACR.
A Clinical Laboratory Model for Evaluating the Acute Effects of Electronic “Cigarettes”: Nicotine Delivery Profile and Cardiovascular and Subjective Effects
Authors: Vansickel Andrea R. , Cobb Caroline O. , Weaver Michael F. , Eissenberg Thomas E. 
Published: August 2010

Abstract
Background: Electronic “cigarettes” are marketed to tobacco users as potential reduced exposure products (PREP), albeit with little information regarding electronic cigarette user toxicant exposure and effects. This information may be obtained by adapting clinical laboratory methods used to evaluate other PREPs for smokers.
Methods: Thirty-two smokers participated in four independent Latin-square ordered conditions that differed by product: own brand cigarette, “NPRO” electronic cigarettes (NPRO EC; 18 mg cartridge), “Hydro” electronic cigarettes (Hydro EC; 16 mg cartridge), or sham (unlit cigarette). Participants took 10 puffs at two separate times during each session. Plasma nicotine and carbon monoxide (CO) concentration, heart rate, and subjective effects were assessed.
Results: Own brand significantly increased plasma nicotine and CO concentration and heart rate within the first five minutes of administration whereas NPRO EC, Hydro EC, and sham smoking did not. Own brand, NPRO EC, and Hydro EC (but not sham) significantly decreased tobacco abstinence symptom ratings and increased product acceptability ratings. The magnitude of symptom suppression and increased acceptability was greater for own brand than for NPRO EC and Hydro EC.
Conclusions: Under these acute testing conditions, neither of the electronic cigarettes exposed users to measurable levels of nicotine or CO, although both suppressed nicotine/tobacco abstinence symptom ratings.
Impact: This study illustrates how clinical laboratory methods can be used to understand the acute effects of these and other PREPs for tobacco users. The results and methods reported here will likely be relevant to the evaluation and empirically based regulation of electronic cigarettes and similar products. Cancer Epidemiol Biomarkers Prev; 19(8); 1945–53. ©2010 AACR.
Oxidatively Damaged DNA/Oxidative Stress in Children with Celiac Disease
Authors: Szaflarska-Popławska Anna , Siomek Agnieszka , Czerwionka-Szaflarska Mieczysława , Gackowski Daniel , Różalski Rafał , Guz Jolanta , Szpila Anna , Zarakowska Ewelina , Oliński Ryszard 
Published: August 2010

Abstract
Background: Because patients with celiac disease face increased risk of cancer and there is considerable circumstantial evidence that oxidatively damaged DNA may be used as a marker predictive of cancer development, we decided, for the first time, to characterize oxidative stress/oxidative DNA damage in celiac disease patients.
Methods: Two kinds of oxidatively damaged DNA biomarkers, namely, urinary excretion of 8-oxodG and 8-oxoGua, and the level of oxidatively damaged DNA in the leukocytes, as well as the level of antioxidant vitamins were analyzed using high-performance liquid chromatography (HPLC) and HPLC/gas chromatography with isotope dilution mass detection methods. These parameters were determined in three groups: (a) children with untreated celiac disease, (b) patients with celiac disease on a strict gluten-free diet, and (c) healthy children.
Results: The mean level of 8-oxodG in DNA isolated from the leukocytes and in the urine samples of the two groups of celiacs was significantly higher than in controls, irrespective of diet. There was no statistically significant difference in these parameters between treated and untreated celiacs. The mean plasma retinol and α-tocopherol concentration in the samples of untreated celiacs was significantly lower than in treated celiacs.
Conclusion: Our results suggest that although diet can be partially responsible for oxidative stress/oxidatively damaged DNA in celiac patients, there is a factor independent of diet.
Impact: It is possible that celiac disease patients may be helped by dietary supplementation rich in vitamin A (and E) to minimize the risk of cancer development. Cancer Epidemiol Biomarkers Prev; 19(8); 1960–5. ©2010 AACR.
Study on a Novel Two-dimensional HPLC and Wide-bore Electrophoresis System
Authors: Li Youxin , Fang Xin , Zhao Shibin , Zhai Tingting , Sun Xiaochun , Bao James Jianmin 
Published: August 2010

Abstract
By precisely fixing an inner cooling capillary to the axial center of a quartz tube, a new and better wide-bore electrophoresis (WBE) system was built and has shown great potential in load capacity and separation efficiency. Further, a novel two-dimensional hybrid of HPLC and WBE system (HPLC–WBE) was developed with an injection valve as the interface. High-resolution and rapid analysis speed were observed in both the WBE system and the 2D HPLC–WBE system. Further work is currently underway.
Seven-coordinate Rhenium(III) Complexes with a Labile Coordination Site Assembled on Indium-doped Tin Oxide (ITO) Electrodes: Catalytic Reduction of Dioxygen to Hydrogen Peroxide
Authors: Sugimoto Hideki , Tano Hiroyuki , Miyake Hiroyuki , Itoh Shinobu 
Published: August 2010

Abstract
The complexes containing seven-coordinate bis(terpyridine)rhenium(III)(OH) moiety with phosphonic acid groups on the ligand have been synthesized and attached on indium-doped tin oxide electrodes. The modified electrodes show pH dependent cyclic voltammograms due to proton-coupled electron transfer and catalyze electrochemical reduction of dioxygen to hydrogen peroxide.
Synthesis and Properties of 1,3-Dithiole[5]dendralenes with Two Thiophene Spacers
Authors: Horiuchi Hiroaki , Misaki Yohji 
Published: August 2010

Abstract
Novel 1,3-dithiole[5]dendralene derivatives with two thiophene spacers 3a and 3b were synthesized. Cyclic voltammetry and spectroelectrochemistry revealed that the positive charges of 3 in the dication and tetracation states mainly distribute on the outer two extended TTF moieties.
<i>In Vitro</i> Dissolution of Aceclofenac Loaded Hydrophilic Polymer Based Matrix Tablets and its Release Mechanism
Authors: Talukder M Mesbah Uddin , Ahmed Nadia , Haque Tasnuva , Chowdhury Sadia Afreen 
Published: August 2010

Hydrophilic polymers are widely used to prepare sustained release matrix tablets. These polymers showed their sustained action by forming a barrier of thick gel layer around the matrix. Here swelling of the polymer and erosion of matrix plays a major role to control the release of the drug. In this present study the swelling and erosion properties of some hydrophilic polymers were correlated to their sustaining and rate controlling behavior. Matrix tablets containing hydroxypropyl methylcellulose (HPMC K100cps), carboxymethyl cellulose (CMC 50,000 cps) and methocel K15M CR polymers were prepared. The powder mixture was evaluated for their flow properties and the prepared tablets for their physical parameters. Swelling and erosion index of the tablets were carried out in pH 6.8 phosphate buffer and dissolution in 0.1N HCl (2 hours) followed by pH 6.8 phosphate buffer (8 hours) using USP apparatus II (paddle method) at 50 r.p.m. HPMC K100 cps was found to be not as rate retarding as the other two. From the all results it was observed that F-6 (containing 43.243% methocel K15M CR) showed highest swelling and erosion index (740.589% and 12.017% respectively), slowest release rate (24.491% at 8 hours) and highest MDT value (55.401 hours). Finally it can be concluded that increasing the polymer concentration or polymer's viscosity grade, swelling and erosion index increases, release rate decreases and MDT value increases. Key words: Aceclofenac; Matrix tablets; HPMC; CMC; Physical parameters; Release kinetics. DOI: 10.3329/bjsir.v45i2.5712Bangladesh J. Sci. Ind. Res. 45(2), 141-150, 2010
Chamilo 2.0: A Second Generation Open Source E-learning and Collaboration Platform
Authors: Maes Jean-Marie 
Published: August 2010

Dokeos used to be one of the leading open source learning platforms. It is well known for the wide range of functions it offers and especially for its ease of use. In many ways it is however a typical first generation learning management system (LMS) consisting of a set of loosely integrated tools. The original design of this LMS has a number of serious drawbacks and limitations. Because of this it was decided to opt for a completely new system that would use state of the art development techniques. The new version is built on a repository of reusable simple and complex content objects, not only documents. The web LCMS is only one of the possible applications that run on that repository. One of the other applications that can make use of the same set of objects is the portfolio. Functions that used to be modules within a course can also simply be used as applications, e.g. forum, assessment, wiki.
All functions such as creating, changing, editing and deleting an object are basically the same platform wide. As a result all modules and applications interact in a far more consistent and less bug prone way. This also greatly simplifies the user interface. This interface that is common to all objects in all tools and modules, makes a number of publication features available that were not available in all tools before, such as categorization, selection of target groups or users, visibility and period of publication. This is certainly adding to Chamiloâ??s ambition to be a user friendly, flexible, fast and consistent platform.
The adaptability of the new system with integrated portal functions and a framework for web services makes it a suitable instrument not only for universities and schools, but also for the business world. In this way Chamilo offers a platform that is ready for future developments in a globalized world where life long learning and collaboration will be central.
Quantifying Tectonic and Geomorphic Interpretations of Thermochronometer Data with Inverse Problem Theory
Authors: Bao G. , Dou Y. , Ehlers T. A. , Li P. , Wang Y. , Xu Z. 
Published: August 2010

AbstractThermochronometer data offer a powerful tool for quantifying a wide range of geologic processes, such as the deformation and erosion of mountain ranges, topographic evolution, and hydrocarbon maturation. With increasing interest to quantify a wider range of complicated geologic processes, more sophisticated techniques are needed. This paper is concerned with an inverse problem method for interpreting the thermochronometer data quantitatively. Two novel models are proposed to simulate the crustal thermal fields and paleo mountain topography as a function of tectonic and surface processes. One is a heat transport model that describes the change of temperature of rocks; while the other is surface process model which explains the change of mountain topography. New computational algorithms are presented for solving the inverse problem of the coupled system of these two models. The model successfully provides a new tool for reconstructing the kinematic and the topographic history of mountains.
Kinetic Monte Carlo Simulation of Metallic Nanoislands Grown by Physical Vapor Deposition
Authors: Bhuiyan Abuhanif K. , Dew S. K. , Stepanova M. 
Published: August 2010

AbstractWe report kinetic Monte-Karlo (KMC) simulation of self-assembled synthesis of nanocrystals by physical vapor deposition (PVD), which is one of most flexible, efficient, and clean techniques to fabricate nanopatterns. In particular, self-assembled arrays of nanocrystals can be synthesized by PVD. However size, shape and density of self-assembled nanocrystals are highly sensitive to the process conditions such as duration of deposition, temperature, substrate material, etc. To efficiently synthesize nanocrystalline arrays by PVD, the process control factors should be understood in detail. KMC simulations of film deposition are an important tool for understanding the mechanisms of film deposition. In this paper, we report a KMC modeling that explicitly represents PVD synthesis of self-assembled nanocrystals. We study how varying critical process parameters such as deposition rate, duration, temperature, and substrate type affect the lateral 2D morphologies of self-assembled metallic islands on substrates, and compare our results with experimentally observed surface morphologies generated by PVD. Our simulations align well with experimental results reported in the literature.
ChemInform Abstract: Is Nickel Dibromide Bent in a Nitrogen Matrix? A Combined Simultaneous Fourier‐Transform Infrared and X‐Ray Absorption Fine Structure Matrix Isolation Study.
Authors: YOUNG N. A. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Acid Terbium(III) Cerium(IV) Sulfate Hydrate, H9Tb7Ce6(SO4)27× 72.2 H2O.
Authors: BARNES J. C. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nanoscale Encapsulation of Molybdenum Carbide in Carbon Clusters.
Authors: HARE J. P. , HSU W. K. , KROTO H. W. , LAPPAS A. , PRASSIDES K. , TERRONES M. , WALTON D. R. M. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electron Impact Mass Spectrometry of Some cis‐ and trans‐4,6‐Diaryl‐2‐ piperidones.
Authors: RAO H. S. P. , BHARATHI B. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Combined Microbial Oxidation and Reduction: A New Approach to the High‐ Yield Synthesis of Homochiral Unsaturated Secondary Alcohols from Racemates.
Authors: FANTIN G. , FOGAGNOLO M. , GIOVANNINI P. P. , MEDICI A. , PEDRINI P. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 2,5‐Disubstituted‐1,3,4‐oxadiazole, 1,5‐Disubstituted‐2‐ mercapto‐1,3,4‐triazole and 2,5‐Disubstituted‐1,3,4‐thiadiazole Derivatives as Potential Antimicrobial Agents.
Authors: VASHI B. S. , MEHTA D. S. , SHAH V. H. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Heteroatom Directed Lithiation Reaction in Organic Synthesis: Synthesis of Styrylphthalans and Functionalized Naphthalenes.
Authors: MALI R. S. , JAGTAP P. G. , BORSE A. U. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Facile Oxidative Decarboxylation of Arylacetic Acids and Oxidation of . alpha.‐Bromoalkyl Ketone by Sodium Metaperiodate in the Presence of Dibenzo‐(18)‐crown‐6 and PTC.
Authors: KORE A. R. , SALUNKHE M. M. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Convenient Preparative Method for the Synthesis of Methyl (Z)‐3‐Aryl‐2‐ (carbobenzoxyamino)acrylates by Wittig‐Horner Reaction with the Use of NEt3 as a Base
Authors: TARAROV V. I. , SAVEL'EVA T. F. , BELOKON' YU. N. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Rearrangement of Methyl α‐(4‐Hydroxy‐3,5‐dimethylphenyl)‐α‐ phenoxy‐β,β,β‐trifluoropropionate
Authors: DYACHENKO V. I. , KOLOMIETS A. F. , FOKIN A. V. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: High Pressure Mediated Asymmetric Diels‐Alder Reaction of Chiral Sulfinylacrylate Derivatives with Furan and 2‐Methoxyfuran.
Authors: YAMAKOSHI Y. N. , GE W.‐Y. , SUGITA J. , OKAYAMA K. , TAKAHASHI T. , KOIZUMI T. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Characterization of Dimers, Trimers, and Tetramers of 3, 6‐Dimethylthieno(3,2‐b)thiophene and 3,6‐Dimethylselenolo(3,2‐b) selenophene.
Authors: NAKAYAMA J. , DONG H. , SAWADA K. , ISHII A. , KUMAKURA S. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Oxidation of Pyrrole α‐Methyl to Methoxymethyl with Ceric Triflate.
Authors: THYRANN T. , LIGHTNER D. A. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Short Step Synthesis of 4‐Substituted Indoles Using Palladium‐ Catalyzed C‐C Bond Forming Reaction.
Authors: DOI K. , MORI M. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.