bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple craniotomies in the management of multifocal and multicentric glioblastoma
Authors: Hassaneen Wael , Levine Nicholas B. , Suki Dima , Salaskar Abhijit L. , de Moura Lima Alessandra , McCutcheon Ian E. , Prabhu Sujit S. , Lang Frederick F. , DeMonte Franco , Rao Ganesh , Weinberg Jeffrey S. , Wildrick David M. , Aldape Kenneth D. , Sawaya Raymond 
Published: August 2010

Object
Multiple craniotomies have been performed for resection of multiple brain metastases in the same surgical session with satisfactory outcomes, but the role of this procedure in the management of multifocal and multicentric glioblastomas is undetermined, although it is not the standard approach at most centers.

Methods
The authors performed a retrospective analysis of data prospectively collected between 1993 and 2008 in 20 patients with multifocal or multicentric glioblastomas (Group A) who underwent resection of all lesions via multiple craniotomies during a single surgical session. Twenty patients who underwent resection of solitary glioblastoma (Group B) were selected to match Group A with respect to the preoperative Karnofsky Performance Scale (KPS) score, tumor functional grade, extent of resection, age at time of surgery, and year of surgery. Clinical and neurosurgical outcomes were evaluated.

Results
In Group A, the median age was 52 years (range 32–78 years); 70% of patients were male; the median preoperative KPS score was 80 (range 50–100); and 9 patients had multicentric glioblastomas and 11 had multifocal glioblastomas. Aggressive resection of all lesions in Group A was achieved via multiple craniotomies in the same session, with a median extent of resection of 100%. Groups A and B were comparable with respect to all the matching variables as well as the amount of tumor necrosis, number of cysts, and the use of intraoperative navigation. The overall median survival duration was 9.7 months in Group A and 10.5 months in Group B (p = 0.34). Group A and Group B (single craniotomy) had complication rates of 30% and 35% and 30-day mortality rates of 5% (1 patient) and 0%, respectively.

Conclusions
Aggressive resection of all lesions in selected patients with multifocal or multicentric glioblastomas resulted in a survival duration comparable with that of patients undergoing surgery for a single lesion, without an associated increase in postoperative morbidity. This finding may indicate that conventional wisdom of a minimal role for surgical treatment in glioblastoma should at least be questioned.
Destructive procedures for control of cancer pain: the case for cordotomy
Authors: Raslan Ahmed M. , Cetas Justin S. , McCartney Shirley , Burchiel Kim J. 
Published: August 2010

Object
Historically, destructive procedures for cancer pain were the main line of treatment therapy. However, the use of high-dose opioids has essentially replaced such procedures. Recognition of the limits of medical therapy to treat cancer pain effectively is growing, while conversely, in regions with limited access to pain medications, the importance of destructive surgical techniques is increasing. A critical evaluation of the evidence for destructive techniques is warranted, and the authors review current evidence underlying these procedures.

Methods
A US National Library of Medicine PubMed search for “ablation,” “DREZ,” “dorsal root entry zone,” “cingulotomy,” “cordotomy,” “ganglionectomy,” “mesencephalotomy,” “myelotomy,” “neurotomy,” “neurectomy,” “rhizotomy,” “sympathectomy,” “thalamotomy,” “tractotomy,” and “pain” was undertaken. The search was then limited to human studies, English-language literature, cancer pain, and reports with more than 1 patient.

Results
One hundred twenty papers were identified and reviewed based on the selection criteria described. According to the Canadian and US task forces, classification of clinical research literature only “sympathectomy” was supported by Class I or II studies, with 2 Class I papers and 1 Class II paper identified for cancer pain. All other procedures were supported by Class III studies of variable quality. Cordotomy in particular was the most extensively studied and reviewed procedure. Given the large number of patients studied, consistent results, multiplicity of reports and, even though evidence quality for individual studies was relatively low, cumulative evidence suggests that cordotomy may play an important role in the treatment of cancer pain.

Conclusions
Destructive procedures for cancer pain may play more than a historic role in the management of cancer pain. Cumulative evidence from even the poorest quality studies suggests that some procedures, such as cordotomy, should be included in the armamentarium available to the neurosurgeon today. To renew appropriate interest in these procedures, evidence and studies that meets today's evidence-based research criteria are warranted.
Phenylboronic-Acid-Based Carbohydrate Binders as Antiviral Therapeutics: Monophenylboronic Acids
Authors: Trippier Paul C , McGuigan Christopher , Balzarini Jan 
Published: August 2010

Background: The development of carbohydrate-binding agents as novel therapeutics for the inhibition of highly glycosylated enveloped viruses has generated much attention in recent literature. Possessing a potential dual mode of action by inhibiting virus entry and exposing the virion to neutralization by the host immune system upon the deletion of envelope glycans under drug pressure, these substances might provide a new direction in antiviral treatment. Phenylboronic acids are widely known to bind the cis-diol functionality of carbohydrate structures, thereby identifying themselves as potential lead structures. To date, few details have been disclosed of the structure–activity relationship of these substances in correlation to their antiviral activity. Methods: In this study, a compound library of a diverse range of ortho-, meta- and para- ring-substituted monophenylboronic acids and glutamine phenylboronic acid analogues was prepared, characterized and evaluated to probe antiviral activity versus a broad range of (enveloped) viruses. Results: The compounds described herein lack antiviral activity. They also did not show measurable binding to HIV type-1 (HIV-1) gp120, using surface plasmon resonance technology. However, of note is the general lack of toxicity, which suggests that further investigation of the compounds as potential therapeutics is needed. Conclusions: The monophenylboronic acids tested exhibited no antiviral activity as potential carbohydrate binders versus a broad range of enveloped and non-enveloped viruses. The compounds tested did not bind HIV-1 gp120, possibly because of their small size and lack of multivalency.
New ideas for an old enzyme: A short, question‐based laboratory project for the purification and identification of an unknown LDH isozyme
Authors: Coleman Aaron B. 
Published: August 2010

AbstractEnzyme purification projects are an excellent way to introduce many aspects of protein biochemistry, but can be difficult to carry out under the constraints of a typical undergraduate laboratory course. We have designed a short laboratory project for the purification and identification of an “unknown” lactate dehydrogenase (LDH) isozyme that can fit into a multiproject course without consuming too many laboratory days. The streamlined purification utilizes ammonium sulfate precipitation, affinity chromatography, and size exclusion chromatography to give good recovery of LDH with minimal equipment requirements, and can be completed in three laboratory periods of 3–4 hours. As part of this, we have designed a novel, qualitative format for an LDH activity assay that allows students to rapidly screen their column chromatography fractions without the need of a spectrophotometer or plate reader. The analysis phase of the project is question‐driven, and can be completed in two laboratory periods. The students must determine which purification technique was most effective by quantifying LDH activity and total protein content at each step of the purification, and then identify their unknown isozyme through agarose gel electrophoresis. This module provides an engaging format for teaching protein biochemistry, with the flexibility to allow an instructor to modify it for their particular curriculum.
Genomics education in practice: Evaluation of a mobile lab design
Authors: Van Mil Marc H.W. , Boerwinkel Dirk Jan , Buizer‐Voskamp Jacobine E. , Speksnijder Annelies , Waarlo Arend Jan 
Published: August 2010

AbstractDutch genomics research centers have developed the ‘DNA labs on the road’ to bridge the gap between modern genomics research practice and secondary‐school curriculum in the Netherlands. These mobile DNA labs offer upper‐secondary students the opportunity to experience genomics research through experiments with laboratory equipment that is not available in schools and place genomics research in a relevant societal context. The design of the DNA lab ‘read the language of the tumor’ is evaluated, by clarifying the goals and choices in the design, and the effects of the DNA lab are presented. Based on the analysis of the design of the DNA lab and supported by the results of the evaluating studies, we consider this module to be a good example of relevant and up‐to‐date genomics education.
ChemInform Abstract: Synthesis and Crystal Structure of (TeCl3)2MoCl6 and β‐(TeCl3) 2ReCl6.
Authors: BECK J. , BIEDENKOPF P. , MUELLER‐BUSCHBAUM K. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: High‐Pressure Synthesis and Single‐Crystal Structure Refinement of Calcium Aurate(III), CaAu2O4.
Authors: LOUZIKOVA A. , RANGE K.‐J. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Rietveld Refinement of the Crystal Structures of the Yttrium Silicon Oxynitrides Y2Si3N4O3 (N‐Melilite) and Y4Si2O7N2 (J‐Phase).
Authors: MACKENZIE K. J. D. , GAINSFORD G. J. , RYAN M. J. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electrochemical Deoxidation of Yttrium‐Oxygen Solid Solutions.
Authors: OKABE T. H. , DEURA T. N. , OISHI T. , ONO K. , SADOWAY D. R. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Substituted M‐ and W‐Type Barium Ferrite Nanostructured Powders by Stearic Acid Gel Method.
Authors: WANG XIAOHUI , LI D. , LU L. , WANG XIN 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: BAC‐MP4 Predictions of Thermochemical Data for C1 and C2 Stable and Radical Hydrofluorocarbons and Oxidized Hydrofluorocarbons.
Authors: ZACHARIAH M. R. , WESTMORELAND P. R. , BURGESS D. R. JUN. , TSANG W. , MELIUS C. F. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electrochemical Formation and Dimerization of α‐Substituted Benzyl Radicals. Steric Effects on Dimerization.
Authors: FRY A. J. , PORTER J. M. , FRY P. F. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel Asymmetric Catalytic Synthesis of Sulfimides.
Authors: TAKADA H. , NISHIBAYASHI Y. , OHE K. , UEMURA S. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Simple Designs for the Construction of Complex Trans‐Fused Polyether Toxin Frameworks. A Convergent Strategy Based on Hydroxy Ketone Cyclization of C‐Linked Oxacycles.
Authors: ALVAREZ E. , PEREZ R. , RICO M. , RODRIGUEZ R. M. , MARTIN J. D. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Reduction. A Convenient Method for the Reduction of Alkynyl Ketones.
Authors: PARKER K. A. , LEDEBOER M. W. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereochemistry of the Enzymic Lactonization of cis,cis‐Muconic and 3‐ Methyl‐cis,cis‐muconic Acid.
Authors: CHEN B. , KIRBY G. W. , RAO G. V. , CAIN R. B. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Convenient One‐Pot Synthesis of β‐Alkylthio Acid Derivatives from Thioacetates and the Corresponding α,β‐Unsaturated Compounds.
Authors: LEE D. W. , CHOI J. , YOON N. M. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Polyhalogenated Heterocyclic Compounds. Part 41. Cycloaddition Reactions Involving Hexafluorobut‐2‐yne and 1,1,1,2,4,4,4‐ Heptafluorobut‐2‐ene.
Authors: CHAMBERS R. D. , ROCHE A. J. , ROCK M. H. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reactions of Diphenylketene and Methylphenylketene with Some cis‐ Cyclohexa‐3,5‐diene‐1,2‐diol Derivatives.
Authors: ROBERTS S. M. , SUTTON P. W. , WRIGHT L. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthetic Application of Et3GeNa/LnCl3: Stereoselective Aldol Condensation of Ketones and Amides.
Authors: YOKOYAMA Y. , MOCHIDA K. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Introduction of Benzo(h)quinoline and 1,10‐Phenanthroline Subunits by Friedlaender Methodology.
Authors: RIESGO E. C. , JIN X. , THUMMEL R. P. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Tetrazole Formation During Bamford‐Stevens Reaction of Diphenaldehyde Bis‐tosylhydrazone.
Authors: BANCIU M. D. , BANCIU A. , DRAGHICI C. , PETRIDE A. , CHIRALEU F. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 3‐Oxa‐ and 3‐Azabicyclo(3.1.0)hexan‐2‐ones via Tandem Radical Cyclization‐Intramolecular SN2 Reactions.
Authors: BALDOVINI N. , BERTRAND M.‐P. , CARRIERE A. , NOUGUIER R. , PLANCHER J.‐M. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reaction of Phosgeniminium Salts with Enolates Derived from Lewis Acid Complexes of 2′‐Hydroxypropiophenones and Related β‐Diketones.
Authors: MORRIS J. , LUKE G. P. , WISHKA D. G. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cycloreversion of 1‐(1‐Naphthyl)‐5‐phenylbicyclo(3.2.0)hept‐6‐ene to 1‐ (1‐Naphthyl)‐4‐phenyl‐1,3‐cycloheptadiene by Triplet Sensitization and Direct Irradiation.
Authors: NAKABAYASHI K. , ARIMURA J. , YASUDA M. , SHIMA K. , TAKAMUKU S. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Practical Molybdenum‐Catalyzed Oxidation of Alcohols by Sodium Percarbonate.
Authors: MAIGNIEN S. , AIT‐MOHAND S. , MUZART J. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Method for Derivatization of Squaric Acid to Highly Substituted Cyclobutenones: Lewis Acid‐Catalyzed Reaction of Cyclobutene‐1,2‐dione Monoacetal and Its Vinylog with Unsaturated Organosilanes, and Subsequent Ring Transformation of the Adducts.
Authors: YAMAMOTO Y. , OHNO M. , EGUCHI S. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Diastereoselectivity in the Lewis Acid Mediated Aldol Reaction of Chiral α,β‐Epoxyaldehydes with a Ketene Silyl Acetal.
Authors: FONTAINE E. , BALTAS M. , ESCUDIER J.‐M. , GORRICHON L. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient Procedure for Palladium‐Catalyzed Hydroformylation of Aryl/Enol Triflates.
Authors: KOTSUKI H. , DATTA P. K. , SUENAGA H. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Hydrocarbonylation of Enol Esters Catalyzed by a Palladium(II) Complex.
Authors: KUDO K. , OIDA Y. , MITSUHASHI K. , MORI S. , KOMATSU K. , SUGITA N. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Superbase‐Promoted Acylation of Hindered Alcohols.
Authors: D'SA B. A. , VERKADE J. G. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Palladium(0) Catalyzed Cross Coupling Reactions of Hindered, Double Activated Aryl Halides with Organozinc Reagents ‐ The Effect of Copper( I) Cocatalysis.
Authors: WEICHERT A. , BAUER M. , WIRSIG P. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: α‐Trifluoromethyl‐Substituted β‐Ethoxyvinyl Zinc Reagent: Preparation and Palladium‐Catalyzed Cross‐Coupling as a Novel Route to Functionalized CF3‐Containing Compounds.
Authors: SHI G. , HUANG X.‐H. , HONG F. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.