bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of lipid profile and obesity in patients with polycystic ovary syndrome
Authors: Parveen Sadaf , Khan Saba , Khan Mohammad Mustufa , Gupta Bhavana , Ahmad Ausaf , Alam Roshan 
Published: April 2024

Abstract

Objective. Abnormal lipid profile and obesity increase the risk of polycystic ovary syndrome (PCOS). PCOS patients may have a greater risk of infertility, metabolic syndrome (MetS) and cardiovascular disease (CVD) due to abnormal lipid profile and obesity. The aim of the study was to find the association between abnormal lipid profile and obesity in patients with PCOS.

Methods. In this case-control study, a total of 102 female subjects (51 diagnosed PCOS and 51 age-matched healthy controls) were enrolled, aged between 20–40 years. Biochemical parameters such as total cholesterol (TC), triglycerides (TG), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), very low-density lipoprotein-cholesterol (VLDL-C), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were estimated. Anthropometric parameters such as body mass index (BMI), waist circumference (WC), hip circumference (HC), and waist-to-hip ratio (WHR) were recorded. A p<0.05 was considered statistically significant.

Results. Mean of BMI, WC, WHR, LH, FSH, TC, TG, LDL-C, and VLDL-C was found significantly elevated in patients with PCOS as compared to controls (p<0.01). However, the mean of HDL-C was found significantly reduced in patients with PCOS as compared to controls (p<0.01). BMI has shown a significant positive correlation with WC (r=0.562, p<0.01) and WHR (r=0.580, p<0.01) among PCOS patients. LH has shown a significant positive correlation with FSH (r=0.572, p<0.01) among PCOS patients. TC has shown a significant positive correlation with TG (r=0.687, p<0.01), LDL-C (r=0.917, p<0.01), and VLDL-C (r=0.726, p<0.01) among PCOS patients.

Conclusion. The results showed that abnormal lipid profile and obesity have a significant association with PCOS patients. Regular monitoring and treatment of PCOS patients are required to reduce the risk of infertility, MetS, and CVD.
Inhibition of signaling protein ERN1 increases the sensitivity of serine synthesis gene expressions to glucose and glutamine deprivations in U87MG glioblastoma cells
Authors: Minchenko Oleksandr H. , Sliusar Myroslava Y. , Khita Olena O. , Minchenko Dmytro O. , Viletska Yuliia M. , Halkin Oleh V. , Levadna Liudmyla O. , Cherednychenko Anastasiia A. , Khikhlo Yevgen P. 
Published: April 2024

Abstract

Objective. Glucose and glutamine supply as well as serine synthesis and endoplasmic reticulum (ER) stress are important factors of glioblastoma growth. Previous studies showed that the knockdown of ERN1 (ER to nucleus signaling 1) suppressed glioblastoma cell proliferation and modified the sensitivity of numerous gene expressions to nutrient deprivations. The present study is aimed to investigate the impact of glucose and glutamine deprivations on the expression of serine synthesis genes in U87MG glioblastoma cells in relation to ERN1 knockdown with the intent to reveal the role of ERN1 signaling pathway on the ER stress-dependent regulation of these gene expressions. Clarification of the regulatory mechanisms of serine synthesis is a great significance for glioblastoma therapy.

Methods. The control U87MG glioblastoma cells (transfected by empty vector) and ERN1 knockdown cells (transfected by dominant-negative ERN1) were exposed under glucose and glutamine deprivation conditions for 16 h. RNA was extracted from cells and reverse transcribed. The expression level of PHGDH (phosphoglycerate dehydrogenase), PSAT1 (phosphoserine amino-transferase 1), PSPH (phosphoserine phosphatase), ATF4 (activating transcription factor 4), and SHMT1 (serine hydroxymethyltransferase 1) genes was studied by real-time qPCR and normalized to ACTB.

Results. It was found that the expression level of genes responsible for serine synthesis such as PHGDH, PSAT1, PSPH, and transcription factor ATF4 was up-regulated in U87MG glioblastoma cells under glucose and glutamine deprivations. Furthermore, inhibition of ERN1 significantly enhances the impact of glucose and especially glutamine deprivations on these gene expressions. At the same time, the expression of the SHMT1 gene, which is responsible for serine conversion to glycine, was down-regulated in both nutrient deprivation conditions with more significant changes in ERN1 knockdown glioblastoma cells.

Conclusion. Taken together, the results of present study indicate that the expression of genes responsible for serine synthesis is sensitive to glucose and glutamine deprivations in gene-specific manner and that suppression of ERN1 signaling significantly modifies the impact of both glucose and glutamine deprivations on PHGDH, PSAT1, PSPH, ATF4, and SHMT1 gene expressions and reflects the ERN1-mediated genome reprograming introduced by nutrient deprivation condition.
PEMANFAATAN POTENSI PEMBANGKITAN DAYA THERMOELEKTRIK PADA KENDARAAN BERMOTOR DENGAN METODE SEEBECK EFFECT
Authors: Olanda Beto , Sari Churnia 
Published: April 2024

<p>Kegiatan manusia erat dengan pemanfaatan inovasi, kendaraan bermotor memudahkan mobilitas manusia. Efisiensi panas kendaraan bermotor sekitar 35-40%, sisanya dibuang begitu saja. Rumusan masalah penelitian ini adalah bagaimana pemanfaatan energi terbuang pada limbah panas kendaraan. Tujuan dari pembuatan perangkat TEG untuk menghasilkan energi listrik ketika perbedaan temperature antara dua material semi konduktor, thermoelektrik akan mengalirkan arus sehingga menghasilkan tegangan dikenal dengan <em>seebeck effect</em>. Metode pengumpulan data berupa observasi secara langsung. Penelitian ini menggunakan kendaraan Honda Tiger 200cc, mendapatkan temperatur sisi panas 105,8°C, selisih temperatur 94,6°C, beda temperatur 11,2°C, tegangan 3,1V, tahanan modul 45,4 Ohm. Hasil perhitungan koefisien seebeck (a) 0,27 V, arus (I) 0,066A, Panas terserap (Qh) 13.05 Watt, Daya (P) dihasilkan 0,204 Watt, dan efisiensi (𝜂) 1,56%. Penelitian ini mengukur perbedaan jarak, waktu, temperatur, dan daya tersimpan dibaterai diperoleh hasil: jarak kurang dari 2 km daya belum bisa, jarak 5 km sampai 15 km waktu tempuh 8 sampai 25 menit, temperatur 69,1 sampai 105,8°C daya tersimpan 120 sampai 480 mAh dan ketika lebih dari 15 km daya tersimpan semakin banyak temperatur maksimal 108°C. Alat berhasil dibuat dengan memanfaatkan limbah panas buang kendaraan menjadi energi listrik yang digunakan sebagai pengecasan atau kebutuhan lainnya.</p>
PERENCANAAN PEMBANGKIT LISTRIK TENAGA SURYA DI GEDUNG LAB TERPADU UNIVERSITAS PGRI MADIUN
Authors: Prasetya Hangga , Sunaryantiningsih Ina , Yuniahastuti Irna Tri 
Published: April 2024

<p>Energi merupakan kebutuhan dasar semua manusia. Sebagian besar kebutuhan energi saat ini dipenuhi oleh energi dari bahan bakar fosil seperti batu bara, minyak, dan gas alam. Namun, pasokan energi saat ini menurun. Jika tidak segera ditangani, tidak menutup kemungkinan akan terjadinya krisis energi. maka tujuan dari penulisan artikel ilmiah ini adalah untuk merancang sebuah Pembangkit Listrik Tenaga Surya (PLTS) di gedung Lab Terpadu Universitas PGRI Madiun sebagai langkah pemanfaatan sumber EBT. Metode pengumpulan data berupa observasi di Lab Terpadu Universitas PGRI Madiun. Perencanaan Pembangkit Listrik Tenaga Surya (PLTS) ini meliputi pemilihan panel surya, inverter, dan kerangka kaki-kaki panel surya. Kemudian dilakukan perhitungan daya <em>output</em> PLTS dan juga penghematan biaya perbulan. Hasil perhitungan dalam perencanaan PLTS ini menunjukkan bahwa daya yang terpasang di Lab Terpadu Universitas PGRI sebesar 197 kVA, sedangkan pemakaian daya di gedung Lab Terpadu Universitas PGRI Madiun dalam sebulan sebesar 15.236 kWh/bulan. PLTS ini mampu membangkitkan daya sebesar 378,8 kWh/hari,yang berarti dimana PLTS mampu membangkitkan daya sebesar 11.364 kWh/bulan. Apabila di asumsikan harga listrik dari PLN saat ini adalah ,berarti PLTS ini telah menghemat sebesar dari biaya tanggungan listrik di gedung Lap Terpadu UNIPMA untuk setiap bulannya.</p>
Modernizing Non-Profit Law in Canada
Authors: Singer Samuel 
Published: April 2024

Non-profit corporations benefit from significant tax subsidies, but they are largely regulated by corporate statutes rather than tax law. Recent legislative reforms in Canada have sought to modernize non-profit statutes to reflect the changing non-profit sector, with a focus on increasing accountability and fairness. Yet, despite the increasingly national reach of non-profits, governance and financial transparency requirements can differ considerably between jurisdictions. This article compares non-profit rules about directors and financial review in Alberta, British Columbia, Ontario, and federally. It demonstrates how modern non-profit law reforms make regulatory choices about governance and financial transparency requirements based on local policy priorities. The article then uses tax expenditure analysis to argue for a national perspective that considers the different regulatory burdens facing non-profits receiving the same federal tax subsidies. It finds that inconsistent rules between jurisdictions raise significant accountability and fairness concerns. For smaller non-profits, uninformed incorporation choices may result in a higher compliance burden. For non-profits seeking a lighter regulatory load, the uneven regulatory landscape may lead to jurisdiction shopping. The article argues that the increased harmonization of non-profit law across Canada is key to continuing the work of modernizing non-profit law. It concludes by identifying potential law reforms and their limitations.
PERSPECTIVA DOS GESTORES DE ENSINO SOBRE A IMPLEMENTAÇÃO DA BNCC NO MUNICÍPIO DE XINGUARA ESTADO DO PARÁ
Authors: Bueno Luciano Teles , Groenwald Claudia Lisete Oliveira 
Published: April 2024

Apresenta-se neste artigo um estudo realizado com os Gestores das Unidades Escolares que possuem os anos finais do Ensino Fundamental e com a Diretora de Ensino dos anos finais do Ensino Fundamental da Secretaria Municipal de Educação e Cultura que estão atuando na implantação da Base Nacional Comum Curricular (BNCC), nas escolas municipais de Xinguara, Pará. A pesquisa é um recorte da tese de doutorado no Programa de Ensino de Ciências e Matemática (PPGECIM), da Universidade Luterana do Brasil (ULBRA), com o objetivo de identificar como vem sendo implantada, pelos professores de Matemática, a BNCC nas escolas públicas de Xinguara, Pará, sob um olhar da Gestão escolar. Foi aplicado um questionário, aos 9 Gestores, das escolas públicas de Xinguara, e uma entrevista com a Diretora de Ensino responsável pelos anos finais do Ensino Fundamental da Secretaria Municipal de Educação. Os resultados apontam que os Gestores participantes da pesquisa apontam as dificuldades enfrentadas pelos professores e gestores na implantação dos objetos de aprendizagem prescritos na BNCC e a dificuldade de construir um Currículo para o desenvolvimento de competências de acordo com o indicado na BNCC.
ESTRATÉGIA DOCENTE PARA REDUÇÃO DO ANALFABETISMO BOTÂNICO EM CURSOS DE FORMAÇÃO DE PROFESSORES DE BIOLOGIA
Authors: Almeida Bruna Mainel , Dorneles Mariane Paludette 
Published: April 2024

Oportunidades de participar em atividades extracurriculares para aprimorar-se durante o processo de formação de professores impulsionam o desenvolvimento da práxis docente, que tornam-se essenciais para a construção de competências e habilidades necessárias para a profissão. Entre essas atividades, destaca-se a monitoria acadêmica, que fortalece o processo de ensino-aprendizagem e favorece a interação entre o professor e os estudantes. A problemática motivadora para este trabalho é: a monitoria em botânica pode contribuir para reduzir o analfabetismo e a invisibilidade botânica? O ponto de partida do presente estudo é a premissa de que a chave para essa questão é o trabalho conjunto do professor formador e do monitor, através de um estudo de caso de monitoria acadêmica na disciplina de Estrutura e Função Vegetal. As atividades foram desenvolvidas uma vez por semana por meio de aulas teórico-práticas durante dois semestres com duas turmas diferentes. Entre as funções realizadas pelo monitor, ressalta-se o auxílio e a organização das práticas, e o suporte aos estudantes durante seu processo de aprendizagem. A monitoria mostrou-se efetiva na diminuição da invisibilidade botânica, a qual auxiliou no processo de ensino-aprendizagem dos estudantes e forneceu um maior apoio ao atendimento individualizado. Oportunizou momentos de reflexão docente entre o professor formador e o estudante monitor, que culminaram em adaptações metodológicas. Também contribuiu significativamente para o crescimento pessoal e intelectual do estudante monitor como futuro professor.
Biochemical indices of blood protein metabolism as criteria of broiler nutrition adequacy
Authors: Kuzmina I. V. , Ovchinnikova N. V. 
Published: April 2024

The experiments were conducted on the broiler chickens of the cross "Smena-9" in the vivarium of the Selective Genetic Centre "Zagorskoe Experimental Breeding Farm" in Sergiev Posad. The results of the blood plasma biochemical tests showed wavelike changes in the trypsin activity at all ages stu- died. The increased concentration of total protein at 7 days of age in all groups could have been induced by switching from endogenous feed when receiving exogenous feed containing more protein than the yolk sac. The age dynamics of the alkaline phosphatase activity had sharp fluctuations throughout the whole rearing period. At 1–7 days of age, there was an increase in the phosphatase activity with a subsequent decrease until 35 days of age relative to the control in all groups. The peak of high activity of this enzyme occurs on the 7th day – 31030 units/l in the control group and on the 14th day in the experimental group 2. Thereafter, there is a gradual decrease in the activity of this enzyme. A sharp increase in the level of alkaline phosphatase in the blood of broiler chickens at 7–21 days of age indicates intensive growth and formation of the organism, but a sharp surge in activity at 7 days of age could also be caused by the transition to a new diet, which in itself is a stress factor. A decrease in the activity of this enzyme at 28–35 days of age indicates a slowdown in the growth process. Consequently, the purpose of this study was to investigate the biochemical composition of blood in different periods of post-embryogenesis of broiler chickens of the cross "Smena-9" at changing the level of protein in the diet, which in this case remains a relevant and informative source of information on the effect of changes in the ingredient composition of feed on the bird organism as a whole.
What does agricultural science need today?
Authors: Akhmetova A. K. , Kiyas A. A. 
Published: April 2024

The article presents some key points of agricultural science existence in the world during the post-pandemic period, the intensive development of digitalization, and the deployment of artificial intelligence. The industry's development is coupled with interdisciplinary sciences, enabling the creation of future scenarios for successful implementation into practice. With tremendous advancement, agricultural science still faces challenges and problems such as outdated agricultural machinery and poor infrastructure in many developing countries. On a global scale, the science addresses sustainable development, soil fertility improvement, and biodiversity conservation in the face of climate change.Many of the solutions to the man-made problems that have been created lead to strong education and reskilling of people on the principle of "life-long learning". Through such approaches, the economic component of agriculture will grow. From the point of view of the research environment, it is necessary to expand research topics in order to close the weak links in the “human-nature” chain. The achievements of agrarian science should find practical application at the local level, involving "farmer-official-scientist" collaboration. There are now many communities, workshops, and platforms promoting educational and practical goals for better agricultural science, combating hunger, nutritious food, and climate change, where one can express personal perspectives and hear from professionals. These events are supported by international organizations such as the United Nations and UNDP, which give a special role to women working in agrarian spheres in order to develop the necessary qualities for practicing agrarian science. Present opportunities have the potential to advance agrarian sciences, drawing from the experiences of advanced countries and adapting them to local conditions, opportunities, and mentalities, with the aim of ensuring high-quality and stable grain production for human food demands.
Analisis Perubahan Hidrograf Aliran Akibat Konversi Tutupan Lahan DAS Keureuto
Authors: Rishaq Alief Muhammad , Nanda Syarifah Asria , Fadhliani Fadhliani , Ersa Nanda Savira , Usrina Nura , Azra Dio Syahlung , Budi Rama 
Published: April 2024

<p align="center"><strong>Abstrak</strong></p><p align="center"> </p><p>Perubahan tata guna lahan akibat peningkatan jumlah penduduk mengakibatkan bertambahnya area pemukiman. Meningkatnya kebutuhan manusia terhadap tempat tinggal dan aktivitas lainnya menyebakan terjadinya beberapa permasalahan lingkungan semakin kompleks. Apabila keadaan ini berlangsung secara terus menerus maka menyebabkan menurunnya kemampuan tanah dalam menyerap dan menampung air hujan terutama di kawasan DAS Krueng Keureuto. Tujuan Penelitian ini adalah mengetahui seberapa besar perubahan tata guna lahan terhadap perubahan hydrograph aliran pada Sub DAS Krueng Keureuto. Data yang digunakan adalah data DEMNAS dan data citra satelit landsat 8 tahun 2015 dan 2021. Berdasarkan peta tata guna lahan tahun 2015 dan 2021, terjadi penambahan luas area ladang sebesar 4,75%, pemukiman 6,34%, perkebunan 11,83%, semak belukar 5,75%, dan sungai 0,21%. Adapun area yang mengalami penurunan luas yaitu hutan sebesar 27,67% dan sawah 1,21%. Hal ini berdampak pada laju limpasan permukaan dan besarnya debit aliran sungai yang terpantau pada outlet DAS Krueng Keureuto.</p><p> </p><p>Kata kunci: <em>tata guna lahan, daerah aliran sungai, keureuto</em></p><p> </p><p align="center"><strong> </strong></p><p align="center"><strong> </strong></p><p align="center"><strong>Abstract</strong></p><p> </p><p>Increasing human needs for housing and other activities have resulted in several complex environmental problems, such as a decrease in the soil capacity to absorb and hold rainwater, especially in the Krueng Keureuto watershed area. The aim of this research is to determine how much land use changes have affected changes in the flow hydrograph in the Krueng Keureuto Sub-watershed. The data used is DEMNAS data and Landsat 8 satellite image data for 2015 and 2021. Based on the 2015 and 2021 land use maps, there has been an increase in the area of fields (4.75%), residential (6.34%), plantations (11.83%), bushes (5.75%), and rivers (0.21%). Meanwhile, the area that experienced a decrease was forest (27.67%) and rice fields (1.21%). This has an impact on the rate of surface runoff and the magnitude of river flow discharge monitored at the outlet of the Krueng Keureuto watershed.</p><p> </p><p>Keywords: <em>land use change, watershed, keureuto</em></p>
Health problems among radiographers: A comparative study in Tirunelveli city
Authors: Rajan Durairaj 
Published: April 2024

This survey based descriptive research work has been undertaken in Tirunelveli city, Tamil Nadu with the objective of examining various health problems of radiographers working in private multi-speciality hospitals and diagnostic centres. In order to know the health-related problems, the present study has examined nine variables related to both physical and mental health. The study has sampled 120 radiographers (60 respondents from private multi-speciality hospitals and 60 from diagnostic centres) using both convenience and judgement sampling techniques. Primary data for the study were collected using questionnaire method. Secondary data were collected from books, journals and websites. Percentage, Mean and Standard Deviation have been administered to understand perception of radiographers towards various health related problems. The result of the study has discovered that tiredness and low energy; body pain; difficulties in sleeping; depression, anger and emotional disturbances; and digestive disorders have been highly perceived by radiographers working in private multi-speciality hospitals than diagnostic centres. Skin and eye problems; urinary tract infection; diabetes mellitus and hypertension; and irregular menstrual, weight loss and hair loss have been equally perceived by radiographers working both in private multi-speciality hospitals and diagnostic centres. The perception of the respondents of both kinds of organizations towards the discussed variables is moderate.
Development in Digital Capitalism: Challenges and Prospects of Nepal
Authors: Pokharel Suman 
Published: April 2024

This study delves into the challenges and possibilities surrounding the establishment of digital capitalism in Nepal. Utilizing a secondary data analysis methodology, it examines the current state of digital capitalism in the country and identifies the key obstacles and opportunities. The theoretical framework employed incorporates concepts like transnational informational capitalism, digital governance, and actor-network theory to comprehend the dynamic relationship between labor, technology, and capitalism in the digital era. The findings indicate that while Nepal has witnessed growth in internet penetration and mobile phone usage, there are still significant disparities in digital access and infrastructure between urban and rural areas. The challenges faced include inadequate digital infrastructure, limited consumer trust and awareness, and the need for more robust regulatory frameworks. Nevertheless, Nepal also holds promising prospects for digital capitalism. The increasing availability of smart-phones a techno-literate youth population, and government initiatives aimed at promoting digital literacy and entrepreneurship contribute to the country's potential in this area. The study underscores the significance of digital capitalism for Nepal's economic development and provides recommendations to policymakers, entrepreneurs, and researchers on how to foster an environment that facilitates the growth of digital capitalism. By addressing the challenges of digital infrastructure, building consumer trust, and strengthening regulatory frameworks, Nepal can harness the benefits of digital capitalism, leveraging it as a catalyst for economic progress in the country.
Korelasi Aplikasi Quizizz Pada Minat Belajar Siswa Di Smk Kristen Bisnis Dan Manajemen Salatiga
Authors: Rolina Deslitia , Efendi Rissal 
Published: April 2024

Tujuan penelitian ini adalah untuk mengetahui Korelasi Aplikasi Quizizz Pada Minat Belajar Siswa di SMK Kristen Bisnis Dan Manajemen Salatiga. Penelitian ini menggunakan variabel bebas yaitu Aplikasi Quizizz dan variabel terikat adalah Minat Belajar Siswa. Pengumpulan data menggunakan skala Aplikasi Quizizz dan skala Minat Belajar Siswa. Subjek penelitian ini adalah Siswa di SMK Kristen Bisnis Dan Manajemen Salatiga. Teknik analisis datanya menggunakan teknik statistik yaitu menggunakan korelasi product moment untuk mencari hubungan antara kedua variabel, serta menghitung koefisien determinasi dan melakukan pengujian hipotesis dengan menggunakan total sampling dengan 45 siswa partisipan. Hasil penelitian diuji korelasi, dengan hasil analisis koefisien korelasi antara Aplikasi Quizizz pada Minat Belajar Siswa di SMK Kristen Bisnis Dan Manajemen Salatiga adalah 0,949 (p < 0,05). Menunjukkan adanya korelasi (r) positif yang signifikan antara Aplikasi Quizizz Pada Minat Belajar Siswa. Aplikasi Quizizz memberikan sumbangan efektif Pada Minat Belajar Siswa sebesar 89,8%.