bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gestational diabetes mellitus care re‐imagined: women's experiences of a major model of care change at a large metropolitan hospital
Authors: Butten Kaley , Laurie Josephine G , Varnfield Marlien , Wilkinson Shelley A 
Published: May 2024

Abstract
Background: A gestational diabetes mellitus (GDM) pregnancy has significant psychological, time and resource impacts. In 2020–21, a digitally‐supported radical GDM service redesign was undertaken at a Brisbane tertiary centre, producing substantial cost savings without compromising clinical outcomes.Aims: To describe women's experiences within this new model of care (MOC), specifically the app user experience (MOC) (post), compared with a traditional MOC (pre).Methods: The new MOC was evaluated using a pre–post study design. This MOC included a smartphone app‐to‐clinician blood glucose communication platform. A convenience sample of women were surveyed about care experiences and app use pre‐ and post‐implementation. An additional survey queried user app experience at four weeks’ postpartum.Results: Within the service, 34% (n=24) and 22% (n=48) of women were surveyed pre and post MOC introduction, respectively. Pre‐implementation, 50% (n=12) of women missed work to attend appointments and 75% spent 30–120 minutes at the hospital. Questions regarding understanding GDM, initial dietary changes and glucometer use received similar or slightly lower ratings, pre‐ to post‐implementation. Nearly a quarter of women in the app‐experiences survey (24.2%; n=177) showed high levels of satisfaction with care received (91.5%) and with the app for managing GDM (87.1%). Two experience themes that emerged were Enhanced GDM management and Usability issues.Conclusions: The new MOC reduced time impositions associated with attending appointments. Despite the removal of face‐to‐face visits in the new MOC, women still established a connection with their treating team and maintained their understanding of their GDM management. Copyright © 2024 John Wiley & Sons.
Novel primary care research is showcased in Brighton at the latest Society for Academic Primary Care annual scientific meeting
Authors: Titmarsh Steve 
Published: May 2024

Is face‐to‐face better than a virtual consultation? How do people feel about artificial intelligence helping with diabetic eye screening? And, are there ethnic variations in infection risk in type 2 diabetes?These were just a small sample of questions that research presented at the 51st Annual Scientific Meeting of the Society for Academic Primary Care, held over two days in Brighton in July 2023, tried to address. Steve Titmarsh reports.
Bioequivalence and the food effect of macitentan/tadalafil 10/20 fixed‐dose combination tablets versus the use of single‐component tablets in healthy subjects
Authors: Ford Jennifer Lynn , Sabet Ahad , Natarajan Jaya , Stieltjes Hans , Chao Daniel L. , Goyal Navin , Csonka Denes 
Published: May 2024

AbstractThe primary aim was to demonstrate bioequivalence between the 10/20 mg fixed‐dose combination (FDC) of macitentan/tadalafil in a single tablet and the free combination of both drugs, and to evaluate the food effect on the 10/20 mg FDC in healthy participants. In this single‐center, randomized, open‐label, 3‐way crossover, single‐dose Phase 1 study in healthy adult participants, macitentan/tadalafil was administered as a 10/20 mg FDC formulation and compared with the free combination of macitentan and tadalafil. The food effect on the FDC was also evaluated. Pharmacokinetic sampling (216 h) was conducted. The 90% confidence intervals (CIs) for the geometric mean ratios of maximum observed plasma analyte concentration (Cmax) and area under the plasma analyte concentration–time curves (AUCs) for Treatment A (FDC, fasted) versus C (free combination, fasted) were within bioequivalence limits demonstrating that the FDC formulation can be considered bioequivalent to the free combination. The 90% CIs for the geometric mean ratios of Cmax and AUC for Treatment B (FDC, fed) versus A (FDC, fasted) were contained within bioequivalence limits demonstrating that there was no food effect. The administration of the 10/20 mg FDC was generally safe and well tolerated in healthy participants. This study demonstrated bioequivalence between the FDC of macitentan/tadalafil (10/20 mg) in a single tablet and the free combination of both drugs in healthy participants, and that the FDC can be taken without regard to food, similarly to the individual components. The FDC was generally safe and well tolerated.
Covariate adjustment and estimation of difference in proportions in randomized clinical trials
Authors: Liu Jialuo , Xi Dong 
Published: May 2024

AbstractDifference in proportions is frequently used to measure treatment effect for binary outcomes in randomized clinical trials. The estimation of difference in proportions can be assisted by adjusting for prognostic baseline covariates to enhance precision and bolster statistical power. Standardization or g‐computation is a widely used method for covariate adjustment in estimating unconditional difference in proportions, because of its robustness to model misspecification. Various inference methods have been proposed to quantify the uncertainty and confidence intervals based on large‐sample theories. However, their performances under small sample sizes and model misspecification have not been comprehensively evaluated. We propose an alternative approach to estimate the unconditional variance of the standardization estimator based on the robust sandwich estimator to further enhance the finite sample performance. Extensive simulations are provided to demonstrate the performances of the proposed method, spanning a wide range of sample sizes, randomization ratios, and model specification. We apply the proposed method in a real data example to illustrate the practical utility.
Nonparametric mean and variance adaptive classification rule for high‐dimensional data with heteroscedastic variances
Authors: Oh Seungyeon , Park Hoyoung 
Published: May 2024

AbstractIn this study, we introduce an innovative methodology aimed at enhancing Fisher's Linear Discriminant Analysis (LDA) in the context of high‐dimensional data classification scenarios, specifically addressing situations where each feature exhibits distinct variances. Our approach leverages Nonparametric Maximum Likelihood Estimation (NPMLE) techniques to estimate both the mean and variance parameters. By accommodating varying variances among features, our proposed method leads to notable improvements in classification performance. In particular, unlike numerous prior studies that assume the distribution of heterogeneous variances follows a right‐skewed inverse gamma distribution, our proposed method demonstrates excellent performance even when the distribution of heterogeneous variances takes on left‐skewed, symmetric, or right‐skewed forms. We conducted a series of rigorous experiments to empirically validate the effectiveness of our approach. The results of these experiments demonstrate that our proposed methodology excels in accurately classifying high‐dimensional data characterized by heterogeneous variances.
Women die here too: maternal mortality as gender‐based violence in Texas
Authors: Oyarvide Tuthill Zelma 
Published: May 2024

AbstractMortality rates among Latin American women reflect the disproportionate exposure to gender‐based violence in the global south. The United States has been critical of national governments in Latin America for their response to prevent and address feminicidios, or gender‐based violence. Yet, data show that women in the United States also die at alarming rates. The United States is facing a maternal mortality problem. Evidence suggests that the maternal mortality rate in the United States is higher relative to other high‐income countries and in Texas the rate is higher than the national average. This paper has three aims. First, I contextualize my discussion of maternal mortality as structural violence within the broader discussions of feminicidios. Second, I outline how state policies in Texas that regulate access to Medicaid and target reproductive rights are a form of structural violence against women because they negatively impact maternal mortality. Finally, I conclude by noting how data visualization that more directly connects the relationship between policies and maternal mortality can expand our understanding of the different ways in which women are systematically harmed.
Encapsulation of Cadmium‐Free InP‐based Quantum Dots in Cross‐Linked Core‐Shell Microparticles via Coaxial Electrospraying
Authors: Babkin Iurii Alekseevich , Bammens Simon , Schiettecatte Pieter , Van Avermaet Hannes , Hens Zeger , Mooter Guy Van den , Clasen Christian 
Published: May 2024

AbstractQuantum dots (QDs) are inorganic semiconductor nanocrystals capable of emitting light. The current major challenge lies in the use of heavy metals, which are known to be highly toxic to humans and pose significant environmental risks. Researchers have turned to indium (In) as a promising option for more environmentally benign QDs, specifically indium phosphide (InP). A significant obstacle remains in sustaining the long‐term photostability of InP‐based QDs when exposed to the environment. To tackle this, electrospraying is used in this work to protect indium phosphide/zinc selenide/zinc sulfide (InP/ZnSe/ZnS) QDs by embedding them within polymer core‐shell microparticles of poly[(lauryl methacrylate)‐co‐(ethylene glycol dimethacrylate)]/poly(methyl methacrylate) (poly(LMA‐co‐EGDMA)/PMMA). During the flight of droplets, the liquid monomer core of LMA and EGDMA with QDs is encapsulated by the solid shell of PMMA formed due to solvent evaporation, resulting in a liquid‐core/solid‐shell particle structure. After that, the captured core of monomers is polymerized into a cross‐linked polymer with the embedded QDs via a thermal initiation. They demonstrate how a successful core‐shell particle formation is achieved to produce structures for initially liquid monomer systems via coaxial electrospraying that are used for cross‐linked polymers, which are of major interest for the encapsulation of InP‐based QDs for generally improved photostability over pristine QDs.
Damage‐Tolerant and Self‐Repairing Web‐Like Borate Type Binder Enable Stable Operation of Efficient Si‐Based Anodes
Authors: Wu Zhuoying , Ma Yongqun , Li Siying , Que Liming , Chen Hongbo , Hao Fei , Tao Xiaole , Xing Hao , Ye Jialin , Qian Dan , Ling Min , Zhu Weiwei , Liang Chengdu 
Published: May 2024

AbstractNovel binder designs are shown to be fruitful in improving the electrochemical performance of silicon (Si)‐based anodes. However, issues with mechanical damage from dramatic volume change and poor lithium‐ion (Li+) diffusion kinetics in Si‐based materials still need to be addressed. Herein, an aqueous self‐repairing borate‐type binder (SBG) with a web‐like architecture and high ionic conductivity is designed for Si and SiO electrodes. The 3D web‐like architecture of the SBG binder enables uniform stress distribution, while its self‐repairing ability promotes effective stress dissipation and mechanical damage repair, thereby enhancing the damage tolerance of the electrode. The tetracoordinate boron ions () in the SBG binder boosts the Li transportation kinetics of Si‐based electrodes. Based on dynamic covalent and ionic conductive boronic ester bonds, the diverse requirements of the binder, including uniform stress distribution, self‐repairing ability, and high ionic conductivity, can be met by simple components. Consequently, the proposed straightforward multifunction design strategy for binders based on dynamic boron chemistry provides valuable insights into fabricating high‐performance Si‐based anodes.
Large‐Substrate‐Terrace Confined Growth of Arrayed Ultrathin PtSe2 Ribbons on Step‐Bunched Vicinal Au(001) Facets Toward Electrocatalytic Applications
Authors: Fu Jiatian , Li Chenyu , Wu Qilong , Hu Jingyi , Lu Yue , Quan Wenzhi , Peng You , Wang Xiangzhuo , Yang Pengfei , Huan Yahuan , Ji Qingqing , Zhang Yanfeng 
Published: May 2024

AbstractUltrathin PtSe2 ribbons can host spin‐polarized edge states and distinct edge electrocatalytic activity, emerging as a promising candidate for versatile applications in various fields. However, the direct synthesis is still challenging and the growth mechanism is still unclear. Herein, the arrayed growth of ultrathin PtSe2 ribbons on bunched vicinal Au(001) facets, via a facile chemical vapor deposition (CVD) route is reported. The ultrathin PtSe2 flakes can transform from traditional irregular shapes to desired ribbon shapes by increasing the height of bunched and unidirectionally oriented Au steps (with step height hstep) is found. This crossover, occurring at hstep ≈ 3.0 nm, defines the tailored growth from step‐flow to single‐terrace‐confined modes, as validated by density functional theory calculations of the different system energies. On the millimeter‐scale single‐crystal Au(001) films with aligned steps, the arrayed ultrathin PtSe2 ribbons with tunable width of ≈20–1000 nm, which are then served as prototype electrocatalysts for hydrogen evolution reaction (HER) is achieved. This work should represent a huge leap in the direct synthesis and the mechanism exploration of arrayed ultrathin transition‐metal dichalcogenides (TMDCs) ribbons, which should stimulate further explorations of the edge‐related physical properties and practical applications.
Folate Receptor Targeting Mn(II) Complex Encapsulated Porous Silica Nanoparticle as an MRI Contrast Agent for Early‐State Detection of Cancer
Authors: Mallik Riya , Saha Muktashree , Ghosh Basab , Chauhan Nisha , Mohan Hari , Kumaran S. Senthil , Mukherjee Chandan 
Published: May 2024

AbstractCancer is recognized as one of the major causes of mortality, however, early‐stage detection can increase the survival chance greatly. It is recognized that folate receptors are gradually overexpressed in the cellular membrane with the progress of cancer from stage 1 to stage 4. Utilizing the fact, herein, developed a porous silica nanoparticle system C1@SiO2–FA–NP; A) impregnated with thermodynamically stable Mn(II) complex (1) molecules within the core of the nanoparticle, and B) surface functionalized with folate units. It exhibited a high longitudinal relaxivity value r1 = 21.45 mM−1s−1 that substantially increased to r1 = 40.97 mM−1s−1 in the presence of 0.67 mM concentration of BSA under the physiological condition. The in vitro fluorescent images after surface conjugation of C1@SiO2–FA–NP with FITC (fluorescein isothiocyanate) buttressed the inclusion of the nanoparticle exclusively within the cancerous HeLa cells than that of healthy HEK293 cells. The importance of the surface‐bound folate unit in the nanoparticle is further established by comparing the fluorescent images of HeLa cells in the absence of the group. Finally, the applicability of C1@SiO2–FA–NP as the T1‐weighted MRI contrast agent for early‐stage cancer diagnosis is established within C57BL/6 mice after infecting the mice with HeLa cells.
Anode‐Free Aqueous Aluminum Ion Batteries
Authors: Lu Cheng , Zhao Fangfang , Tao Bowen , Wang Zhilong , Wang Ying , Sheng Jiaping , Tang Gen , Wang Yue , Guo Xiang , Li Jinjin , Wei Liangming 
Published: May 2024

AbstractAqueous aluminum ion batteries (AAIBs) possess the advantages of high safety, cost‐effectiveness, eco‐friendliness and high theoretical capacity. However, the Al2O3 film on the Al anode surface, a natural physical barrier to the plating of hydrated aluminum ions, is a key factor in the decomposition of the aqueous electrolyte and the severe hydrogen precipitation reaction. To circumvent the obnoxious Al anode, a proof‐of‐concept of an anode‐free AAIB is first proposed, in which Al2TiO5, as a cathode pre‐aluminum additive (Al source), can replenish Al loss by over cycling. The Al‐Cu alloy layer, formed by plating Al on the Cu foil surface during the charge process, possesses a reversible electrochemical property and is paired with a polyaniline (cathode) to stimulate the battery to exhibit high initial discharge capacity (175 mAh g−1), high power density (≈410 Wh L−1) and ultra‐long cycle life (4000 cycles) with the capacity retention of ≈60% after 1000 cycles. This work will act as a primer to ignite the enormous prospective researches on the anode‐free aqueous Al ion batteries.
Construction of Cs2AgBiCl6/COF Heterojunction for Boosted Photocatalytic Thioester Oxidation
Authors: Qin Qi , Xia Zhi‐Hua , Liu Wei‐Qi , Chen Hong‐Yan , Kuang Dai‐Bin 
Published: May 2024

AbstractLead‐free halide perovskites as a new kind of potential candidate for photocatalytic organic synthesis have attracted much attention recently. The rational heterojunction construction is regarded as an efficient strategy to delicately regulate their catalytic performances. Herein, a semi‐conductive covalent organic framework (COF) nanosheet, C4N, is employed as the functional component to construct Cs2AgBiCl6/C4N (CABC/C4N) heterojunction. It is found that the C4N nanosheets with rich surface functional groups can serve as heterogeneous nucleation sites to manipulate the growth of CABC nanocrystals and afford close contact between each other, therefore facilitate the transfer and spatial separation of photogenerated charge carriers, as verified by in situ X‐ray photoelectronic spectroscopy and Kelvin probe force microscopy. Moreover, the oxygen affinity of C4N endows the heterojunctions with outstanding aerobic reactivity, thus improving the photocatalytic performance largely. The optimal CABC/C4N heterojunction delivers a thioanisole conversion efficiency of 100% after 6 h, which is 2.2 and 7.7‐fold of that of CABC and C4N. This work provides a new ideal for the design and application of lead‐free perovskite heterojunction photocatalysts for organic reactions.
Propositional logic, paradox, and Indian dialectics – towards a deeper ontological approach in paradox theory
Authors: Fritzsche Albrecht 
Published: May 2024

AbstractThe article responds to the call of organizational paradox theorists to explore the added value of eastern principles of thought as a basis for a better understanding of the treatment of contradictory opposites in organisations. Drawing on prior work in systems theory, it presents a logical analysis of paradox based on the Catuṣkoṭi or Tetralemma discussed in Madhyamika Buddhism. Unlike its predecessors, the article reads the Tetralemma as an expression of a gradual process of detachment from the subject matter in question, resulting from a change of perspective. On this basis, the article is able to distinguish two different accounts of paradox in organisations, one resulting from excess determinacy and the other resulting from a lack of determinacy. For organisational practice, this means that the perception of and attitude towards values, routines, strategy or identity needs more attention in the study of paradox, which Indian dialectics might facilitate.
Seismic control of tall buildings using vertically distributed multiple tuned mass dampers
Authors: Akhlagh Pasand Ali , Zahrai Seyed Mehdi 
Published: May 2024

SummaryTuned mass damper (TMD) is a seismic vibration control device used to reduce wind and seismic vibrations of structures. Although TMD is attractive to many researchers due to its simplicity, optimizing its parameters and positions is very challenging. The sensitivity of TMD to structure's frequency changes is among its weaknesses and if parameters of this system are not optimally tuned, the efficiency of this system decreases. To solve this problem, multiple tuned mass dampers (MTMDs) have been proposed. In this research, in order to study and compare single tuned mass damper (STMD) with MTMDs vertically distributed according to modal analysis, a 20‐story building is used. The structure is analyzed in OpenSees under seven ground motions with a peak ground acceleration (PGA) of 1.0 g. To optimize TMD parameters, particle swarm optimization (PSO) algorithm is used and the results are compared to those obtained from Den Hartog's approach. To be able to use PSO algorithm and optimize TMD design parameters, Matlab and OpenSees are linked together. In this paper, more than one vibration mode is used to tune and distribute dampers to overcome higher mode effects in high‐rise buildings. The results showed that depending on their different layouts and different optimization methods used, MTMDs reduce the average maximum responses of the structure by up to 12.1%. This is while STMD is able to reduce maximum responses of the structure by 4.3%.
Implementing multi‐trait genomic selection to improve grain milling quality in oats (Avena sativa L.)
Authors: Dhakal Anup , Poland Jesse , Adhikari Laxman , Faryna Ethan , Fiedler Jason , Rutkoski Jessica E. , Arbelaez Juan David 
Published: May 2024

AbstractOats (Avena sativa L.) provide unique nutritional benefits and contribute to sustainable agricultural systems. Breeding high‐value oat varieties that meet milling industry standards is crucial for satisfying the demand for oat‐based food products. Test weight, thins, and groat percentage are primary traits that define oat milling quality and the final price of food‐grade oats. Conventional selection for milling quality is costly and burdensome. Multi‐trait genomic selection (MTGS) combines information from genome‐wide markers and secondary traits genetically correlated with primary traits to predict breeding values of primary traits on candidate breeding lines. MTGS can improve prediction accuracy and significantly accelerate the rate of genetic gain. In this study, we evaluated different MTGS models that used morphometric grain traits to improve prediction accuracy for primary grain quality traits within the constraints of a breeding program. We evaluated 558 breeding lines from the University of Illinois Oat Breeding Program across 2 years for primary milling traits, test weight, thins, and groat percentage, and secondary grain morphometric traits derived from kernel and groat images. Kernel morphometric traits were genetically correlated with test weight and thins percentage but were uncorrelated with groat percentage. For test weight and thins percentage, the MTGS model that included the kernel morphometric traits in both training and candidate sets outperformed single‐trait models by 52% and 59%, respectively. In contrast, MTGS models for groat percentage were not significantly better than the single‐trait model. We found that incorporating kernel morphometric traits can improve the genomic selection for test weight and thins percentage.
Multiple urogenital abnormalities and urine incontinence in a sexually ambiguous goat (Capra aegagrus hircus)
Authors: Le Kayla , Wai Seng (Darrel) , Righter Brenda , Weber Katherine , Ruppert Stephani 
Published: May 2024

AbstractA 6‐month‐old, phenotypic, male Nigerian dwarf goat presented after bilateral abdominal gonadectomy for persistent urinary incontinence. Physical examination revealed a caudally positioned cliteropenis with an abnormally enlarged urethral opening. Abdominal ultrasound and computed tomography revealed a fluid‐filled structure dorsal to the urinary bladder. The structure was removed by caudal midline laparotomy. Communication between the structure and proximal urethra was confirmed in surgery. Unexpected separation of the structure from the urethra in surgery necessitated normograde catheterisation through a cystotomy to pull a catheter retrograde into the bladder. Histopathology confirmed the structure as a hypoplastic uterus. The goat regained normal urine continence following surgery.