bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hepatic hemangioma in a simple liver cyst mimicking biliary cystic neoplasm
Authors: Karashima Ryuichi , Yamamura Kensuke , Oda Eri , Ozaki Nobuyuki , Ishiko Takatoshi , Nagayama Yasunori , Yamada Rin , Komohara Yoshihiko , Koba Ikuro , Beppu Toru 
Published: May 2024

Abstract
Background
Follow-up is recommended for an asymptomatic unilocular hepatic cystic lesion without wall-thickness and nodular components. A few liver cystic lesions represent biliary cystic neoplasms, which are difficult to differentiate from simple cysts with benign mural nodules on imaging alone.

Case presentation
An 84-year-old woman with a history of simple liver cyst diagnosed one year prior was admitted for evaluation of a developed mural nodule in the cystic lesion. She had no specific symptoms and no abnormalities in blood tests except for carcinoembryonic antigen (5.0 ng/mL) and carbohydrate antigen (43.5 U/mL) levels. Contrast-enhanced computed tomography revealed a well-defined, low-attenuation lesion without a septum that had enlarged from 41 to 47 mm. No dilation of the bile duct was observed. A gradually enhancing mural nodule, 14 mm in diameter, was confirmed. MRI revealed a uniform water-intense cystic lesion with a mural nodule. This was followed by T2-enhanced imaging showing peripheral hypointensity and central hyperintensity. Enhanced ultrasonography revealed an enhanced nodule with a distinct artery within it. A needle biopsy of the wall nodule or aspiration of intracystic fluid was not performed to avoid tumor cell spillage. The possibility of a neoplastic cystic tumor could not be ruled out, so a partial hepatectomy was performed with adequate margins. Pathologically, the cystic lesion contained a black 5 mm nodule consisting of a thin, whitish fibrous wall and dilated vessels lined by CD31 and CD34 positive endothelial cells. The final diagnosis was a rare cavernous hemangioma within a simple liver cyst.

Conclusions
Cavernous hemangiomas mimicking well-enhanced mural nodules can arise from simple liver cysts. In less malignant cases, laparoscopic biopsy or percutaneous targeted biopsy of the mural nodules, together with needle ablation, may be recommended to avoid unnecessary surgery.
The effect of probiotic-fortified kefir on cardiovascular risk factors in elderly population: a double-blind, randomized, placebo-controlled clinical trial
Authors: Noori Mehran , Shateri Zainab , Babajafari Siavash , Eskandari Mohammad Hadi , Parastouei Karim , Ghasemi Mohammad , Afshari Hoseein , Samadi Mohammad 
Published: May 2024

Abstract
Introduction
The outbreak of cardiovascular disease (CVD) augments with age. Gut dysbiosis can worsen or initiate systemic disorders such as metabolic diseases and CVDs. Therefore, this research aimed to assess the effect of kefir fortified with Lactobacillus helveticus R0052 and Bifidobacterium longum R017 on CVD risk factors in the elderly population. The subjects of this study were selected from the Motahari Clinic in Shiraz, Iran.

Method
This study was a double-blind, randomized, and controlled clinical trial that was conducted on 67 elderly people who were randomly divided into two groups: the fortified kefir group (n = 32), which received one bottle of fortified kefir (240 cc), and the placebo group (n = 35), which received one bottle of regular kefir for eight weeks. To analyze the data, SPSS software was applied.

Results
After eight weeks, significant differences were seen in atherogenic and Castell’s risk index I between the fortified and regular groups (p = 0.048 and p = 0.048, respectively). No significant differences were found in Castelli’s risk index II, high-density lipoprotein cholesterol (HDL-C), total cholesterol, triglycerides (TG), non-HDL-C, TG-cholesterol index, and fasting blood sugar by comparing the two groups.

Conclusion
Our investigation demonstrated that fortified kefir with probiotics did not significantly affect lipid profiles. Still, it could significantly affect some indices, including Castelli’s risk index I and atherogenic index. More studies are required to confirm the findings and mechanisms of probiotics’ effect on CVD risk factors.

Trial number
The present registered at the Iranian Registry of Clinical Trials (IRCT20130227012628N3) at 2023-02-21.
Effect of nano-curcumin supplementation on angina status, and traditional and novel cardiovascular risk factors in overweight or obese patients with coronary slow flow phenomenon: a randomized double-blind placebo-controlled clinical trial
Authors: Rezaei Mahsa , Soltani Mitra , Alipoor Elham , Rezayat Seyed Mahdi , Vasheghani-Farahani Ali , Yaseri Mehdi , Firouzi Ata , Hosseinzadeh-Attar Mohammad Javad 
Published: May 2024

Abstract
Background
Cardiovascular events and poor quality of life are frequently observed in patients with coronary slow flow phenomenon (CSFP). This trial evaluated the effect of nano-curcumin supplement containing curcuminoids, as multifunctional nutraceuticals, on angina status, and some traditional and novel cardiovascular risk factors in overweight or obese patients with CSFP.

Methods
In this double-blind, randomized, placebo-controlled clinical trial, 42 overweight or obese patients with CSFP received either 80 mg/day of nano-curcumin or placebo for 12 weeks. Seattle angina questionnaire (SAQ) as a clinical measure of angina status, circulating endocan, adropin, homocysteine, lipid profile, and the novel scores of visceral adiposity index (VAI) and waist-triglyceride index (WTI) were assessed before and after the intervention. The independent samples t-test, Mann-Whitney test, analysis of covariance, Chi-square, and Fisher’s exact tests were used where appropriate.

Results
All domains of SAQ including physical limitation, angina stability, angina frequency-severity, treatment satisfaction, and disease perception and quality of life improved significantly in the nano-curcumin compared with the placebo group. No significant changes were observed in serum endocan, adropin, and homocysteine following the intervention. Triglycerides, triglyceride/high-density lipoprotein cholesterol ratio, WTI and VAI values improved significantly only within the nano-curcumin group.

Conclusions
Supplementation with 80 mg/day nano-curcumin (containing curcuminoids) for 12 weeks significantly improved clinically important disease-specific aspects of health in patients with CSFP. Some traditional and novel cardiovascular risk factors improved significantly only compared with the baseline values, which need further investigation.

Trial registration
This study was approved by the Ethics Committee of Tehran University of Medical Sciences (IR.TUMS.VCR.REC.1398.794). The study protocol was registered at Iranian Registry of Clinical Trials by IRCT20131125015536N8 registration ID at 19.06.2019.
Determinants of low birth weight and its effect on childhood health and nutritional outcomes in Bangladesh
Authors: Islam Md. Zahidul , Chowdhury Mohammad Rocky Khan , Kader Manzur , Billah Baki , Islam Md. Shariful , Rashid Mamunur 
Published: May 2024

Abstract
Background
The high incidence of low birth weight (LBW) is associated with an increased risk of infant mortality, adverse pregnancy outcomes for mothers, and a decline in overall health and well-being. The current study aimed to identify the various determinants of LBW and its effect on adverse health and nutritional outcomes of children aged 0–23 months in Bangladesh.

Methods
Bangladesh Demography and Health Survey (BDHS) 2017-18 data was used. A chi-square test and multivariable logistic regression analysis were used to find out the associations between independent variables and outcomes (e.g., LBW, child illness and undernutrition).

Results
The overall prevalence of LBW among was 16.3%. Mother with no formal education (AOR = 2.64, 95% CI = 0.55–3.30, p = 0.01), female child (AOR = 1.31, 95% CI = 1.04–1.65, p = 0.023); and poorest economic status (AOR = 1.69, 95% CI = 1.13–2.51, p = 0.010), were identified significant determinants of LBW. Of home environment and hygiene factors, unimproved toilet facilities (AOR = 1.38, 95% CI = 1.03–1.84, p = 0.030) had a significant effect on LBW. In addition, children born with LBW were more likely to suffer fever (AOR = 1.26, 95% CI = 1.05–1.60, p = 0.050), stunting (AOR = 2.42, 95% CI = 1.86–3.15, p = < 0.001), wasting (AOR = 1.47, 95% CI = 1.02–2.25 p = 0.049), and underweight (AOR = 3.19, 95% CI = 2.40–4.23, p = < 0.001).

Conclusion
One out of five children was LBW in Bangladesh. Maternal education, sex of child, wealth index, and toilet facilities had significant effects on LBW. In addition, LWB contributed to children’s poor health and nutritional outcomes. Enhancing maternal pregnancy, and child health outcomes necessitates policies addressing poverty, gender inequality, and social disparities. Key strategies include promoting regular prenatal care, early medical intervention, reproductive health education, and safe hygiene practices. To combat the negative impacts of LBW, a comprehensive strategy is vital, encompassing exclusive breastfeeding, nutritional support, growth monitoring, accessible healthcare, and caregiver education.
Private landowner interest in prescribed fire in California: findings from workshops in the Sierra Nevada
Authors: Wilkin Kate M. , Stasiewicz Amanda M. , Kocher Susan D. 
Published: May 2024

Abstract
Background
Globally, prescribed fire political interest and practice has been rekindled following recent devastating wildfire seasons. This phenomenon was especially acute in areas with dual wildfire and forest health crises, like California. Previous research has investigated prescribed fire on public lands or on private lands in other regions, but little is known about prescribed fire practice or interest on private lands in California. Therefore, we sought to understand private land managers’ perceptions of prescribed fire compared to other land management techniques, treatment pathways, motivations, and barriers to complete these treatments in California.

Results
Before workshops on prescribed fire for private lands, we surveyed participants in six prescribed fires on private lands workshops in the Central Sierra Nevada from 2018 to 2019 (N = 172). We found that participants “want to use” pile burns and broadcast prescribed fires more than other land management treatments. There was also a strong interest in mechanical treatments in contrast to low interest in grazing. Some participants had “heard about” and “want to use” some pathways to apply prescribed fire on their lands, including government programs, contractors, friends and family, and Prescribed Burn Associations (PBAs). People had multiple objectives for their prescribed fire goals, and the majority wanted to promote ecosystem health, e.g., reduce fire hazards, foster natural land health, and reduce invasive plants. Perceived barriers were greatest for safety, cost, and resources while fewer participants perceived permits as a barrier.

Conclusion
Participants were in the early stages of considering using broadcast prescribed fire and would like to burn small areas, potentially to build confidence and skills. At the time of our research, there was strong interest in using prescribed fire on private lands, and some perceived best pathways and barriers to be unique from prescribed fire practice on public lands. At the same time, private lands managers who responded said they want to promote ecosystem health and reduce wildfire risk and impacts, which is a shared a common motivation with public lands managers. Studies and reports on prescribed burning need to clearly distinguish between broadcast prescribed burning and pile burning to ensure consistency in results and conclusions about prescribed fire use.
Intraperitoneal versus intranasal administration of lipopolysaccharide in causing sepsis severity in a murine model: a preliminary comparison
Authors: Jiao Yaqing , Tong Cindy S. W. , Zhao Lingyun , Zhang Yilin , Nicholls John M. , Rainer Timothy H. 
Published: May 2024

AbstractCommunity-acquired respiratory infection is the commonest cause of sepsis presenting to emergency departments. Yet current experimental animal models simulate peritoneal sepsis with intraperitoneal (I.P.) injection of lipopolysaccharide (LPS) as the predominant route. We aimed to compare the progression of organ injury between I.P. LPS and intranasal (I.N.) LPS in order to establish a better endotoxemia murine model of respiratory sepsis. Eight weeks old male BALB/c mice received LPS-Escherichia coli doses at 0.15, 1, 10, 20, 40 and 100 mg per kg body weight (e.g. LPS-10 is a dose of 10 mg/kg body weight). Disease severity was monitored by a modified Mouse Clinical Assessment Score for Sepsis (M-CASS; range 0–21). A M-CASS score ≥ 10 or a weight reduction of ≥ 20%, was used as a criterion for euthanasia. The primary outcome was the survival rate (either no death or no need for euthanasia). The progression of disease was specified as M-CASS, body weight, blood glucose, histopathological changes to lung, liver, spleen, kidney, brain and heart tissues. Survival rate in I.P. LPS-20 mice was 0% (2/3 died; 1/3 euthanized with M-CASS > 10) at 24 h. Survival rate in all doses of I.N. LPS was 100% (20/20; 3–4 per group) at 96 h. 24 h mean M-CASS post-I.P. LPS-10 was 6.4/21 significantly higher than I.N. LPS-10 of 1.7/21 (Unpaired t test, P < 0.05). Organ injury was present at 96 h in the I.P. LPS-10 group: lung (3/3; 100%), spleen (3/3; 100%) and liver (1/3; 33%). At 24 h in the I.P. LPS-20 group, kidney injury was observed in the euthanized mouse. At 96 h in the post-I.N. LPS-20 group, only lung injury was observed in 2/3 (67%) mice (Kruskal-Wallis test with Dunn’s, P < 0.01). At 24 h in the post-I.N. LPS-100 group all (4/4) mice had evidence of lung injury. Variable doses of I.N. LPS in mice produced lung injury but did not produce sepsis. Higher doses of I.P. LPS induced multi-organ injury but not respiratory sepsis. Lethal models of respiratory virus, e.g., influenza A, might provide alternative avenues that can be explored in future research.
Role of pre-operative endovascular embolization of a giant sacrococcygeal teratoma in neonate: a case report
Authors: Zainal Isa Azzaki , Fuad Nik Farhan Nik , Yang Leong Yuh , Ismail Nik Azuan Nik , Yaacob Nur Yazmin , Zakaria Rozman 
Published: May 2024

Abstract
Background
Giant sacrococcygeal teratomas (SCTs) are at risk of perinatal morbidity and mortality due to their high vascularity. Pre-operative embolization of the feeding arteries, prior to complete surgical resection, may assist in minimizing the intraoperative blood loss by occluding these feeding arteries.

Case presentation
We present a case of a highly vascular giant SCT in a neonate, which was successfully embolized through an endovascular approach prior to surgery. The femoral artery approach was chosen, with access established using a Micropuncture introducer as a sheath. Embolization was performed using a combination of microcoils, Gelfoam slurry, and polyvinyl alcohol particles. The patient developed femoral artery spasm post-procedure, which resolved with the application of a glyceryl trinitrate patch.

Conclusions
Performing pre-operative endovascular embolization on a giant sacrococcygeal teratoma presents particular challenges, primarily due to the difficulty in assessing small vessels and the potential complications associated with this procedure. Nevertheless, this technique proves exceptionally valuable in helping the surgeon minimize blood loss during surgery, thereby reducing the risks of morbidity and mortality. Comprehensive planning for the embolization procedure is essential, encompassing the identification of potential vascular access points and alternatives, along with careful selection of the appropriate catheter.
Antibacterial activity of medicinal plants and their role in wound healing
Authors: Breijyeh Zeinab , Karaman Rafik 
Published: May 2024

AbstractBackgroundThe study of plant-based medications, or phytomedicine, involves a wide spectrum of biological activities. Due to the existence of secondary metabolites, herbal medicine has been used and practiced throughout history for the treatment of both acute and chronic conditions. Over the past century or so, numerous novel compounds with medicinal potential have been derived from plants. In the age of growing super infections and the emergence of resistant strains, natural medicines are inspiring optimism.Main body of the abstractThe review discusses the role of herbal medicine as antibacterial agents and their use in wound care and management of wounds and the critical role of secondary metabolites of herbal plants in fighting bacterial infections. Some medicinal plants such as St. John’s wort (SJW) (Hypericum perforatum), Rosemary (Rosmarinus officinalis), Ginger (Zingiber officinale), and nopal cactus (Opuntia ficusindica(L.)) also possess wide range of biological activities and can give a synergistic effect if combined with antibiotics. In addition, natural biopolymers play an important role in the management of wounds as well as the physiological processes of the skin (hemostasis, inflammation, proliferation, and remodelling).MethodA narrative review of papers relevant to the use of phytomedicine in treating infections was conducted by using electronic databases PubMed, CrossREF, and Google Scholar.Short conclusionPhytomedicine is one of the top options for the treatment of chronic illnesses for millions of people around the world. To learn about the bioactive components of medicinal plants, their medical benefits, and their synergistic or additive effects to enhance the action of medications, substantial new studies are still needed.Graphical abstract
Home exercise is considered essential, but patient compliance remains a mystery
Authors: Tombak Yasemin , Karaahmet Ozgur Zeliha , Umay Ebru , Akyuz Ece Unlu , Gurcay Eda 
Published: May 2024

Abstract
Background
Regular exercise is essential in the treatment of Ankylosing Spondylitis (AS), as the main goals of the treatment are to reduce pain, restore function, avoid disability and structural deterioration, and improve quality of life (QoL). The purpose of this study is to ascertain whether patients adhere to exercise recommendations and to evaluate the effects of consistent exercise on patients' pain, function, disease activity, mood, and quality of life. Many studies emphasize the need for exercise in treatment of AS, but none reveal whether patients follow prescribed practices and the results of doing so.

Results
Exercising group had significantly decreased pain, erythrocyte sedimentation rate and Bath ankylosing spondylitis functional index and Bath ankylosing spondylitis disease activity index (BASDAI) scores (p < 0.05). There was no significant difference between the two groups in morning stiffness, mood, spinal mobility, and QoL parameters (p > 0.05). Regular exercise was positively correlated with physiotherapy history. Regression analysis revealed that with an increase of 1 unit in visual analog scale and BASDAI, regular exercise decreased by 0.087 and 0.116 units, respectively.

Conclusion
Our study revealed how much the patients considers and follows the recommended exercises and concluded that regular exercise habits should be developed since they offer promising effects in treatment of AS, hence, patients should be educated in this area, and particular exercise routines should be developed to encourage them to exercise.
AVALIAÇÃO DO REGISTRO DE ENFERMAGEM SOBRE PARADA CARDIORRESPIRATÓRIA E REANIMAÇÃO CARDIOPULMONAR COMPARADO AO MODELO UTSTEIN
Authors: Oliveira Santos Andressa , Matos Amaral Jocelio , Da Silva Teixeira Loren Scarlatt , Neves Ribeiro Regina , Steffens Ana Paula 
Published: May 2024

Introdução: Os casos de Parada Cardiorrespiratória devem ser registrados de forma completa e detalhada, desde a sua causa até as intervenções realizadas a fim de obter o retorno da circulação espontânea. Objetivo: Avaliar a qualidade dos registros de enfermagem sobre parada cardiorrespiratória e reanimação cardiopulmonar com base no modelo Utstein. Materiais e métodos: Estudo transversal, exploratório - descritivo, quantitativo, realizado em duas Unidades de Terapia Intensiva, com avaliação em prontuário de registros de parada cardiorrespiratória e reanimação cardiopulmonar com retorno da circulação espontânea ou óbito, pelo período de dois meses. Resultados: Foram avaliados 41 registros, de pacientes com idade entre 22 e 79 anos, sendo 14 (51,9%) homens. Em 13 (31,7%) registros não havia descrição de quaisquer manobras de reanimação e, quando descritos, na maioria deles não havia especificação das intervenções realizadas. A descrição da causa da parada cardiorrespiratória estava ausente em 38 (92,7%) e do ritmo em 37 (90,3%) registros. Em mais da metade não havia registros dos tempos dos eventos e nem um mencionava quais os profissionais envolvidos na reanimação cardiopulmonar. Conclusão: Todas as anotações estavam incompletas frente ao modelo Utstein, isso dificulta a obtenção de dados para realização de pesquisas sobre a temática e expõe a precariedade do registro realizado sem método sistemático.
Exploring the role of evidence-based educational resources and brokering in the wake of political trauma
Authors: Kornbluh Mariah , Davis Amanda , Dunn Alyssa Hadley , Brezicha Kristina 
Published: May 2024

Background
The research-practice gap has not been explored within civics education, and in particular the role of evidence-based civics curriculum in times of political trauma. Such research is critical in equipping educators with evidence-based resources to help mitigate political trauma experienced by students. Here, we explore the types of resources teachers access as well as the role of Brokers, Intermediaries and Boundary Spanners (BIBS) in connecting teachers to such sources after the historic 6 January 2021 US Capitol insurrection.

Aims and objectives
This study poses the following research questions: (1) what resources did teachers utilise to support their students following the 6 January 2021 Capitol insurrection; and (2) who were key BIBS in connecting teachers to such information and what role did research evidence have in the generation of such materials?

Methods
Using cross-sectional survey data, we analyse the open-ended text-based responses from educators reflecting on the days after 6 January 2021.

Findings
The study illuminates’ trends in: (1) the type of resources teachers utilise to address students’ needs (educational curricula, social media, news outlets); and (2) the role of BIBS in connecting them to such information (media platforms, mass media, educational non-profit organisations).

Discussion and conclusion
In the face of political trauma, educators present civics crises as ‘open issues’ and struggle to access frameworks to support research-based pedagogy. Findings illuminate the potential of a BIBS framework that works to further support educators in facilitating conversations and evidence-based pedagogies with their students that rebuke such injustices.