bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishment, Maintenance, and In Vitro and In Vivo Applications of Primary Human Glioblastoma Multiforme (GBM) Xenograft Models for Translational Biology Studies and Drug Discovery
Authors: Carlson Brett L. , Pokorny Jenny L. , Schroeder Mark A. , Sarkaria Jann N. 
Published: March 2011

AbstractDevelopment of clinically relevant tumor model systems for glioblastoma multiforme (GBM) is important for advancement of basic and translational biology. One model that has gained wide acceptance in the neuro‐oncology community is the primary xenograft model. This model entails the engraftment of patient tumor specimens into the flank of nude mice and subsequent serial passage of these tumors in the flank of mice. These tumors are then used to establish short‐term explant cultures or intracranial xenografts. This unit describes detailed procedures for establishment, maintenance, and utilization of a primary GBM xenograft panel for the purpose of using them as tumor models for basic or translational studies. Curr. Protoc. Pharmacol. 52:14.16.1‐14.16.23. © 2011 by John Wiley & Sons, Inc.
Hybrid time slots sequencing model for a class of scheduling problems
Authors: Castro Pedro M. , Zeballos Luis J. , Méndez Carlos A. 
Published: March 2011

AbstractThis article presents a new model for the short‐term scheduling of multistage batch plants with a single unit per stage, mixed storage policies, and multiple shared resources for moving orders between stages. Automated wet‐etching stations for wafer fabrication in semiconductor plants provide the industrial context. The uncommon feature of the continuous‐time model is that it relies on time grids, as well as on global precedence sequencing variables, to find the optimal solution to the problem. Through the solution of a few test cases taken from the literature, we show that new model performs significantly better than a pure sequencing formulation and better than a closely related hybrid model with slightly different sequencing variables. We also propose a new efficient heuristic procedure for extending the range of problems that can effectively be solved, which essentially solves relaxed and constrained versions of the full‐space model. © 2011 American Institute of Chemical Engineers AIChE J, 2012
The maximal acceleration, extended relativistic dynamics and Doppler type shift for an accelerated source
Authors: Friedman Y. 
Published: March 2011

AbstractBased on the generalized principle of relativity and the ensuing symmetry, it has been shown that if the Clock Hypothesis is not true, there is a universal maximal acceleration am. We present here an extension of relativistic dynamics for which all admissible solutions will have have a speed bounded by the speed of light c and the acceleration bounded by am. An additional Doppler type shift for an accelerated source is predicted. The formulas for such shift are the same as for the usual Doppler shift with v/c replaced by a/am. The W. Kündig experiment of measurement of the transverse Doppler shift in an accelerated system was also exposed to a longtitudal shift due to the acceleration. This experiment, as reanalyzed by Kholmetskii et al., shows that the Clock Hypothesis is not valid. Based on the results of this experiment, we predict that the value of the maximal acceleration am is of the order 1019m/s2. Moreover, our analysis provides a way to measure experimentally the maximal acceleration with existing technology.
Paper 5: Surveillance of multiple congenital anomalies: Implementation of a computer algorithm in European registers for classification of cases
Authors: Garne Ester , Dolk Helen , Loane Maria , Wellesley Diana , Barisic Ingeborg , Calzolari Elisa , Densem James ,   a EUROCAT Working Group
Published: March 2011

AbstractBACKGROUNDSurveillance of multiple congenital anomalies is considered to be more sensitive for the detection of new teratogens than surveillance of all or isolated congenital anomalies. Current literature proposes the manual review of all cases for classification into isolated or multiple congenital anomalies.METHODSMultiple anomalies were defined as two or more major congenital anomalies, excluding sequences and syndromes. A computer algorithm for classification of major congenital anomaly cases in the EUROCAT database according to International Classification of Diseases (ICD)v10 codes was programmed, further developed, and implemented for 1 year's data (2004) from 25 registries. The group of cases classified with potential multiple congenital anomalies were manually reviewed by three geneticists to reach a final agreement of classification as “multiple congenital anomaly” cases.RESULTSA total of 17,733 cases with major congenital anomalies were reported giving an overall prevalence of major congenital anomalies at 2.17%. The computer algorithm classified 10.5% of all cases as “potentially multiple congenital anomalies”. After manual review of these cases, 7% were agreed to have true multiple congenital anomalies. Furthermore, the algorithm classified 15% of all cases as having chromosomal anomalies, 2% as monogenic syndromes, and 76% as isolated congenital anomalies. The proportion of multiple anomalies varies by congenital anomaly subgroup with up to 35% of cases with bilateral renal agenesis.CONCLUSIONSThe implementation of the EUROCAT computer algorithm is a feasible, efficient, and transparent way to improve classification of congenital anomalies for surveillance and research. Birth Defects Research (Part A), 2011. © 2011 Wiley‐Liss, Inc.
Purification of chondroitin precursor from Escherichia coli K4 fermentation broth using membrane processing
Authors: Schiraldi Chiara , Carcarino Immacolata Loredana , Alfano Alberto , Restaino Odile Francesca , Panariello Andrea , De Rosa Mario 
Published: March 2011

AbstractRecently the possibility of producing the capsular polysaccharide K4, a fructosylated chondroitin, in fed‐batch experiments was assessed. In the present study, a novel downstream process to obtain chondroitin from Escherichia coli K4 fermentation broth was developed. The process is simple, scalable and economical. In particular, downstream procedures were optimized with a particular aim of purifying a product suitable for further chemical modifications, in an attempt to develop a biotechnological platform for chondroitin sulfate production. During process development, membrane devices (ultrafiltration/diafiltration) were exploited, selecting the right cassette cut‐offs for different phases of purification. The operational conditions (cross‐flow rate and transmembrane pressure) used for the process were determined on an ÄKTA cross‐flow instrument (GE Healthcare, USA), a lab‐scale automatic tangential flow filtration system. In addition, parameters such as selectivity and throughput were calculated based on the analytical quantification of K4 and defructosylated K4, as well as the major contaminants. The complete downstream procedure yielded about 75% chondroitin with a purity higher than 90%.
Sol and gel states in peptide hydrogels visualized by Gd(III)‐enhanced magnetic resonance imaging
Authors: Weerasekare Mahika , Taraban Marc B. , Shi Xianfeng , Jeong Eun‐Kee , Trewhella Jill , Yu Yihua Bruce 
Published: March 2011

AbstractThe hydrogels assembled from a pair of self‐repulsive but mutually attractive decapeptides are visualized by magnetic resonance imaging (MRI). It is found that in the absence of Gd(III)‐chelate, gelation has little effect on MRI signal intensity. In the presence of Gd(III)‐chelate, gelation leads to significant changes in water relaxation and MR signal intensity. The sol to gel transition is best visualized by T2‐weighted imaging using large echo time with the sol producing a bright spot and the gel producing a dark spot. MRI studies point to high local Gd(III)‐chelate concentration. Small‐angle X‐ray scattering study indicates that this local enrichment of Gd(III)‐chelate has two contributing processes: first, the aggregation of peptides into fibers; second, within peptide fibers, Gd(III)‐chelate further aggregate into clusters. This work demonstrates that the status of peptide‐based hydrogels can be visualized by MRI with the aid of covalently linked Gd(III)‐chelates. This result has implications for monitoring peptide scaffolds in vivo. © 2011 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 96: 734–743, 2011.
Chlorobis(pentafluoroethyl)phosphane: Improved Synthesis and Molecular Structure in the Gas Phase
Authors: Hayes Stuart A. , Berger Raphael J. F. , Mitzel Norbert W. , Bader Julia , Hoge Berthold 
Published: March 2011

Abstract(C2F5)2PCl is now accessible through a significantly improved synthesis protocol starting from the technical product (C2F5)3PF2. (C2F5)3PF2 was reduced in the first step with NaBH4 in a solvent‐free reaction at 120 °C. The product, P(C2F5)3, was treated with an excess of an aqueous sodium hydroxide solution to afford the corresponding phosphinite salt Na+(C2F5)2PO− selectively under liberation of pentafluoroethane. Subsequent chlorination with PhPCl4 resulted in the selective formation of (C2F5)2PCl, which was isolated by fractional condensation in an overall yield of 66 %. The gas electron diffraction (GED) pattern for (C2F5)2PCl was recorded and found to be described by a two‐conformer model. A quantum chemical investigation of the potential‐energy surface revealed the possible existence of many low‐energy conformers, each with a number of low‐frequency vibrational modes and therefore large‐amplitude motions. The conformer calculated to be most stable was also found to be most abundant by GED and comprised 61(5) % of the total. The molecular structure parameters determined by GED were in good agreement with those calculated at the MP2/TZVPP level of theory; the only significant difference was a discrepancy of about 3° in the C‐P‐C angle, which, for the lowest‐energy conformer, was refined to 98.2(4)° and was calculated to be 94.9°.
(4+3) Cycloaddition Reactions of Nitrogen‐Stabilized Oxyallyl Cations
Authors: Lohse Andrew G. , Hsung Richard P. 
Published: March 2011

AbstractThe use of heteroatom‐substituted oxyallyl cations in (4+3) cycloadditions has had a tremendous impact on the development of cycloaddition chemistry. Extensive efforts have been exerted toward investigating the effect of oxygen, sulfur, and halogen substituents on the reactivity of oxyallyl cations. Most recently, the use of nitrogen‐stabilized oxyallyl cations has gained prominence in the area of (4+3) cycloadditions. The following article will provide an overview of this concept utilizing nitrogen‐stabilized oxyallyl cations.
ChemInform Abstract: Structure, Properties, and Theoretical Electronic Structure of UCuOP and NpCuOP.
Authors: Wells Daniel M. , Ringe Emilie , Kaczorowski D. , Gnida D. , Andre G. , Haire Richard G. , Ellis Donald E. , Ibers James A. 
Published: March 2011

AbstractThe title compounds are prepared by solid state reaction of U or Np, Cu and/or CuO, and P at 1073—1273 K (evacuated silica tube, 96 h).
ChemInform Abstract: Synthesis of LiNi0.5Mn1.5O4 by Solid‐State Reaction with Improved Electrochemical Performance.
Authors: Feng X. Y. , Shen C. , Fang X. , Chen C. H. 
Published: March 2011

AbstractThe title compound is synthesized from a mixture of Ni(OAc)2 and Mn(OAc)2 (alumina crucible, 500 °C, 5 h) followed by addition of LiOAc (calcination at 500 °C for 5 h, sintering at 900 °C for 10 h, and annealing at 700 °C for 10 h) and in a one‐step reaction directly from a mixture of Ni(OAc)2, Mn(OAc)2, and LiOAc (900 °C).
ChemInform Abstract: A Gallium‐Catalyzed Cycloisomerization/Friedel—Crafts Tandem.
Authors: Li Hui‐Jing , Guillot Regis , Gandon Vincent 
Published: March 2011

AbstractIt is found that GaCl3 efficiently promotes double, triple, and even quadruple hydroarylation of diverse arenynes which allows formation of various valuable polycyclic compounds.
ChemInform Abstract: Regioselectivity in Intermolecular Pauson—Khand Reactions of Dissymmetric Fluorinated Alkynes.
Authors: Kizirian Jean‐Claude , Aiguabella Nuria , Pesquer Albert , Fustero Santos , Bello Paula , Verdaguer Xavier , Riera Antoni 
Published: March 2011

AbstractThe reaction proceeds strictly regioselectively: the fluorinated substituent is always found at the α‐position to the enone.
ChemInform Abstract: Toward a Novel Approach to Bis‐β‐Lactam Synthesis Using Vilsmeier Reagent as an Efficient Entity via Staudinger Cycloaddition Reaction.
Authors: Meshram Jyotsna , Ali Parvez , Tiwari Vandana 
Published: March 2011

AbstractVilsmeier reagent is shown to act as acid activator reagent for the direct [2 + 2] ketene—imine cycloaddition of acetic acid (II) and bisimines (I).
ChemInform Abstract: An Efficient Synthesis of α‐Methylene‐γ‐butyrolactones from Baylis—Hillman Adducts via an In‐Mediated Barbier Reaction and Stereoselective Lactonization under MeSO2Cl/Et3N Conditions.
Authors: Park Bo Ram , Kim Ko Hoon , Kim Jae Nyoung 
Published: March 2011

Abstractsyn‐Homoallylic alcohols (I), derived from Baylis—Hillman adducts, are converted into trans‐butyrolactones via an intramolecular mesylate displacement.
ChemInform Abstract: Three‐Component Assembly and Divergent Ring‐Expansion Cascades of Functionalized 2‐Iminooxetanes.
Authors: Yao Weijun , Pan Lianjie , Zhang Yiping , Wang Gang , Wang Xiaoqin , Ma Cheng 
Published: March 2011

AbstractReactions of α‐keto esters with N‐sulfonylketimines, prepared in situ from terminal alkynes and azide (III), proceeds via 2‐iminooxetane intermediates such as (VII) which are transformed into maleimide derivatives or 5‐iminopyrrolidinones.
ChemInform Abstract: A Mild, Efficient and Eco‐Friendly Synthesis of 1,3‐Bis(4‐arylthiazol‐2‐yl)benzenes in PEG‐400.
Authors: Noie Jalil , Khosropour Reza 
Published: March 2011

AbstractA selective and green synthesis which proceeds in the recycable and reusable reaction medium PEG is presented.
ChemInform Abstract: Application of Biphasic Reaction Procedure Using Ferric Chloride Dissolved in an Imidazolium Salt and Benzotrifluoride (FeIm‐BTF Procedure) to Aza‐Prins Cyclization Reaction.
Authors: Hasegawa Eietsu , Hiroi Nohara , Osawa Chika , Tayama Eiji , Iwamoto Hajime 
Published: March 2011

AbstractA combination of FeCl3 and [bmim]FeCl4 (or [bmim]PF6) promotes the cyclization of homoallylic N‐tosylamine (I) with aldehydes using benzotrifluoride as the solvent.
ChemInform Abstract: Rhodium(III)‐Catalyzed Synthesis of Isoquinolines from Aryl Ketone O‐Acyloxime Derivatives and Internal Alkynes.
Authors: Too Pei Chun , Wang Yi‐Feng , Chiba Shunsuke 
Published: March 2011

AbstractThe method allows the preparation of a broad spectrum of highly functionalized isoquinolines.
ChemInform Abstract: 1,3‐Dichloro‐5,5‐dimethylhydantoin as a Novel and Efficient Homogeneous Catalyst in Biginelli Reaction.
Authors: Hojati Seyedeh Fatemeh , Gholizadeh Mostafa , Haghdoust Mahnaz , Shafiezadeh Fatemeh 
Published: March 2011

AbstractThe use of a stable, easily available and efficient catalyst in the title reaction is established.
ChemInform Abstract: Reactions of 1‐Amino‐5‐morpholino‐6,7,8,9‐tetrahydrothieno [2,3‐c]isoquinoline‐2‐carbonitrile.
Authors: El‐Dean Adel M. Kamal , Radwan Shaban M. , Zaki Remon M. 
Published: March 2011

AbstractA variety of fused heterocyclic compounds including triazolopyrimidothienotetrahydroisoquinolines is synthesized starting from the title carbonitrile (I).
ChemInform Abstract: Design, Synthesis and Biotest of a Bicyclo[3.3.1]nonane Analogue (V) of 2‐Amino‐5,6‐dihydro‐4H‐1,3‐thiazine.
Authors: Zefirova Olga N. , Nurieva Evgeniya V. , Chupakhin Vladimir I. , Semenova Irina S. , Peregud Danil I. , Onufriev Mikhail V. , Gulyaeva Natalia V. 
Published: March 2011

AbstractWith the aim to enhance the lipophilicity of the title thiazine NO‐synthase inhibitor, its bridgehead analogue (V) is synthesized.
ChemInform Abstract: Generation and Reactions of an Unsubstituted N‐Heterocyclic Carbene Boryl Anion.
Authors: Monot Julien , Solovyev Andrey , Bonin‐Dubarle Helene , Derat Etienne , Curran Dennis P. , Robert Marc , Fensterbank Louis , Malacria Max , Lacote Emmanuel 
Published: March 2011

AbstractReduction of boryl iodide (I) with LDBB and subsequent trapping of the resulting N‐heterocyclic carbene boryl anion with various electrophiles yields derivatives that would be difficult to access with existing methods.
ChemInform Abstract: A Borylative Cyclization Towards Indole Boronic Esters.
Authors: Huang Jianhui , Macdonald Simon J. F. , Harrity Joseph P. A. 
Published: March 2011

AbstractA convenient procedure for the synthesis of indole boronic esters is developed using palladium‐catalyzed borylative cyclization of 2‐alkynylanilines with bis(pinacolato)diboron.
ChemInform Abstract: Palladium‐Catalyzed Asymmetric Synthesis of Axially Chiral Allenylsilanes and Their Application to SE2′ Chirality Transfer Reactions.
Authors: Ogasawara Masamichi , Okada Atsushi , Subbarayan Velusamy , Soergel Sebastian , Takahashi Tamotsu 
Published: March 2011

AbstractThe desilylative SE2′ reactions of the axially chiral allenylsilanes proceed with complete transfer of the chirality to the newly formed tertiary and quaternary stereocenters of the resulting propargylic derivatives.
ChemInform Abstract: Rongalite®‐Promoted Odorless and Highly Regioselective Synthesis of β‐Hydroxyselenides under Solvent‐Free Conditions.
Authors: Lv Guangshu , Li Ting , Hu Ruijia , Chen Jiuxi , Ding Jinchang , Wu Huayue 
Published: March 2011

AbstractAn efficient and simple procedure reenders possible the highly regioselective synthesis of β‐hydroxyselenides by ring‐opening of epoxides with 1,2‐diphenylselenide under solvent‐free conditions.
ChemInform Abstract: Glycerol as a Promoting Medium for Cross‐Coupling Reactions of Diaryl Diselenides with Vinyl Bromides.
Authors: Goncalves Loren C. , Fiss Gabriela F. , Perin Gelson , Alves Diego , Jacob Raquel G. , Lenardao Eder J. 
Published: March 2011

AbstractA glycerol/CuI/Zn mixture efficiently catalyzes the title reaction and can be completely reused at least four times.
ChemInform Abstract: Synthesis and Structure of m‐Terphenyl Thio‐, Seleno‐, and Telluroethers.
Authors: Zakai Uzma I. , Bloch‐Mechkour Anna , Jacobsen Neil E. , Abrell Leif , Lin Guangxin , Nichol Gary S. , Bally Thomas , Glass Richard S. 
Published: March 2011

AbstractThe structures of the title compounds are determined by spectroscopic means and X‐ray analysis.
ChemInform Abstract: Synthesis of Some Novel Glucosyl Triazoles from 2,3,4,6‐Tetra‐O‐pivaloyl‐D‐glucopyranosyl Azide.
Authors: Shen Chao , Zheng Hui , Zhang Pengfei , Chen Xinzhi 
Published: March 2011

AbstractA series of novel glycosyl triazoles (IV) is synthesized using “click chemistry”.
ChemInform Abstract: Convertible Formation of Different Glycoside Using Molecular Iodine.
Authors: Saeeng Rungnapha , Sirion Uthaiwan , Sirichan Yada , Trakulsujaritchok Thanida , Sahakitpichan Poolsak 
Published: March 2011

AbstractA convertible formation between 2,3‐unsaturated glycosides and 2‐deoxy‐2‐iodoglycosides is observed if the glycosylation is performed using iodine as a versatile reagent under different conditions.
ChemInform Abstract: Microwave‐Accelerated Click Chemistry: Expeditious Synthesis of Novel Triazole‐Linked Salicylic β‐D‐O‐Glycosides with PTP1B Inhibitory Activity.
Authors: Yang Jin‐Wei , Li Cui , He Xiao‐Peng , Zhao Hong , Gao Li‐Xin , Zhang Wei , Shi Xiao‐Xin , Tang Yun , Li Jia , Chen Guo‐Rong 
Published: March 2011

AbstractGlycosides (IIIb) and (IVa) demonstrate potent inhibitory activity against protein tyrosine phosphatase 1B.
ChemInform Abstract: Formal Total Synthesis of Enantiopure Tricyclic (S)‐Myrmicarin Alkaloids 217, 215A and 215B.
Authors: Santarem Marco , Vanucci‐Bacque Corinne , Lhommet Gerard 
Published: March 2011

AbstractThe formal synthesis of (S)‐myrmicarin alkaloids is achieved by the preparation of pyrroloindolizidine (IV) in 12 steps and 7% overall yield starting from pyrrolidine (I).
ChemInform Abstract: Synthesis of Acinetobactin.
Authors: Takeuchi Yasuo , Ozaki Satoru , Satoh Masahiro , Mimura Ken‐ichiro , Hara Sei‐ichi , Abe Hitoshi , Nishioka Hiromi , Harayama Takashi 
Published: March 2011

AbstractAcinetobactin (II) is synthesized and its absolute configuration is clarified.
ChemInform Abstract: Synthesis and in vitro Inotropic Evaluation of 2‐(4‐Substitutedbenzyl‐1,4‐diazepan‐1‐yl)‐N‐(4,5‐dihydro‐1‐phenyl [1,2,4]triazolo[4,3‐a]quinolin‐7‐yl)acetamides.
Authors: Jiang Sheng‐Ming , Ye Bai‐Jun , Liu Xue‐Kun , Zhang Tian‐Yi , Cui Xun , Piao Hu‐Ri 
Published: March 2011

Abstract16 Compounds of type (I) are prepared and evaluated for their positive inotropic activities.
Activation of dendritic cells via TLR7 reduces Foxp3 expression and suppressive function in induced Tregs
Authors: Hackl Daniela , Loschko Jakob , Sparwasser Tim , Reindl Wolfgang , Krug Anne B. 
Published: March 2011

AbstractExogenous and endogenous RNA ligands of Toll‐like receptor (TLR) 7 which are present during viral infection or autoimmune diseases such as systemic lupus erythematosus (SLE) directly activate DCs and B cells and thus support the generation of effector T and B lymphocytes. However, the generation of effective antiviral or autoreactive adaptive immune responses requires blocking of immunosuppression by Tregs. In this study, we show that TLR7 ligands reduce the number of Tregs generated de novo from naïve murine T cells in vitro and in vivo. In the presence of TLR7‐activated splenic DCs, Foxp3 was transiently induced in naïve T cells by TGF‐β but was downregulated at later time points. Neutralization experiments revealed that loss of Foxp3 after initial induction was mostly dependent on IL‐6 produced in the DC–T‐cell cocultures containing TLR7 ligands. Thus, under the influence of TLR7 ligands fewer Tregs were generated and these expressed lower levels of Foxp3 correlating with a reduced capacity to suppress responder T‐cell proliferation. Thus, we provide evidence that TLR7 ligands affect Treg‐dependent immune regulation and may thereby contribute to the development of autoimmune diseases such as systemic lupus erythematosus.
ApoB (XbaI) polymorphism and lipid variation in Teharnian population
Authors: Daneshpour Maryam S , Faam Bita , Hedayati Mehdi , Eshraghi Parisa , Azizi Fereidoun 
Published: March 2011

AbstractThis study examines the association of XbaI apolipoprotein B polymorphism with lipid related variables in Tehran lipid and glucose study. 809 subjects from the TLGS population were selected, anthropometrical and biochemical factors were measured. A segment of the apo B gene in exon 26 was amplified by PCR and the polymorphism was revealed by RFLP using XbaI restriction enzyme. Allele frequencies obtained for X+ and X− were 27.6 and 72.4%, respectively. Presence of the X+ allele was significantly associated with increased levels of total cholesterol (p 0.048), apolipoprotein B (p 0.018), and low‐density lipoprotein (p 0.022). The associations were significant even after adjustment for age, BMI, smoking, and history of diabetes. There are some relationships between the presence of different alleles of XbaI polymorphism with serum cholesterol, apoB, and LDL‐C concentration. These findings highlight the importance of variation in this gene on some lipid related factors levels.