bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: New Three‐Component Glyoxylation—Decarbonylative Stille Coupling Sequence to Acyl Heterocycles under Mild Conditions.
Authors: Tasch Boris O. A. , Merkul Eugen , Frank Walter , Mueller Thomas J. J. 
Published: October 2010

AbstractA convenient one‐pot procedure is developed for the title process of indoles or pyrroles.
ChemInform Abstract: First Example of a Synthesis of the Tetracyclic 2,4‐Di(tert‐butyl)‐6,7‐dihydrofuro[2′,3′:3,4]cyclohepta[1,2‐b]indole System.
Authors: Butin A. V. , Kostyukova N. O. , Tsiunchik F. A. , Lysenko S. A. , Trushkov I. V. 
Published: October 2010

AbstractTitle compounds (II) are obtained by the action of POCl3 and a drop of water on bisfurylmethanes (I).
ChemInform Abstract: Novel Antiinflammatory Agents Based on Pyrazole Based Dimeric Compounds; Design, Synthesis, Docking and in vivo Activity.
Authors: Tewari Ashish Kumar , Srivastava Priyanka , Singh Ved Prakash , Singh Amit , Goel Raj Kumar , Mohan Chethampadi Gopi 
Published: October 2010

AbstractThe biological in vivo evaluation of the synthesized mutual ester prodrugs such as (V) and (VI) shows the presence of antiinflammatory activity.
ChemInform Abstract: Synthesis of 3,5‐Diaryl‐4‐(1H‐imidazol‐2‐yl)‐1H‐pyrazoles from 2‐Phenacyl‐1H‐imidazole.
Authors: Dzvinchuk I. B. , Nesterenko A. M. , Lozinskii M. O. 
Published: October 2010

AbstractThe previously unknown title compounds (IV) are synthesized through thermal intramolecular cyclocondensation of hydrazones (III).
ChemInform Abstract: Synthesis of Benzimidazoles and Benzoxazoles Using Palladium Bis(2,2,6,6‐Tetramethyl‐3,5‐heptanedionate) as a Novel Catalyst.
Authors: Bhor Malhari D. , Bhanage Bhalchandra M. 
Published: October 2010

AbstractThe title catalyst (PTMHD) is efficiently used for the preparation of benzimidazoles, e.g. (III) and (VI), and benzoxazoles such as (VIII).
ChemInform Abstract: Synthesis, Characterization and in vivo Anthelmintic Activity of Some Novel N‐Mannich Bases of Benzimidazoles.
Authors: Murti Yogesh , Arora Rashmi , Pathak Devender 
Published: October 2010

AbstractMost of the title compounds (I)‐(III) exhibit significant anthelmintic activities against Eudrilus species.
ChemInform Abstract: Efficient Suzuki and Stille Reactions for Regioselective Strategies of Incorporation of the 1,3‐Oxazole Heterocycle: Mild Desulfonylation for the Synthesis of C‐4 and C‐5 Monosubstituted Oxazoles.
Authors: Williams David R. , Fu Liangfeng 
Published: October 2010

AbstractVarious oxazole substrates can be used for successful title reactions.
ChemInform Abstract: Direct Access to Variously Substituted 2‐Imino‐4‐thiazolines.
Authors: Attanasi Orazio A. , Favi Gianfranco , Filippone Paolino , Perrulli Francesca R. , Santeusanio Stefania 
Published: October 2010

AbstractThiocyanic acid, generated in situ from KSCN and acetic acid, reacts with 1,2‐diaza‐1,3‐butadienes to afford intermediate α‐thiocyanato hydrazones.
ChemInform Abstract: Preparation and N‐Alkylation of 4‐Aryl‐1,2,4‐triazoles.
Authors: Holm Stefanie C. , Siegle Alexander F. , Loos Christian , Rominger Frank , Straub Bernd F. 
Published: October 2010

AbstractA simple solvent‐free protocol allows the preparation of biologically interesting title compounds from dihydrochloride (I) and anilines via direct transamination.
ChemInform Abstract: γ‐Lactonizations of 2H‐Chromenes via Cyclopropanation.
Authors: Stokes Sean , Spears Ben , Laseter Cameron , Barker Bobby , Mead Keith T. 
Published: October 2010

AbstractThe two‐step sequence involves cyclopropanation of 2H‐chromenes with diazo esters and Lewis acid promoted ring expansion of the resulting cyclopropanes.
ChemInform Abstract: Enantioselective Synthesis of 3,4‐Chromanediones via Asymmetric Rearrangement of 3‐Allyloxyflavones.
Authors: Marie Jean‐Charles , Xiong Yuan , Min Geanna K. , Yeager Adam R. , Taniguchi Tohru , Berova Nina , Schaus Scott E. , Porco John A. Jr. 
Published: October 2010

AbstractThe 3,4‐chromanediones are trapped with phenylenediamine and ethylenediamine to afford chiral pyrazine derivatives.
ChemInform Abstract: Amberlite IRA‐400 (OH‐) as a Catalyst in the Preparation of 4H‐Benzo[b]pyrans in Aqueous Media.
Authors: Khodaei Mohammad Mehdi , Bahrami Kiumars , Farrokhi Azita 
Published: October 2010

AbstractAmberlite IRA‐400 (OH‐) is an effective and reusable catalyst for the synthesis of the title benzopyrans (IV) (12 examples) via one‐pot, three component condensation of dimedone, aldehydes and malononitrile.
ChemInform Abstract: Highly Enantioselective Formal aza‐Diels—Alder Reactions with Acylhydrazones and Danishefsky′s Diene Promoted by a Silicon Lewis Acid.
Authors: Lee Sharon K. , Tambar Uttam K. , Perl Nicholas R. , Leighton James L. 
Published: October 2010

AbstractLewis acidic oxazasilolane (I) is successfully applied as promoter in the formal aza‐Diels—Alder reaction of acylhydrazones (II) towards Danishefsky diene (III).
ChemInform Abstract: A Facile Synthesis and Discovery of Highly Functionalized Tetrahydropyridines and Pyridines as Antimycobacterial Agents.
Authors: Raju Suresh Kumar , Stephen Michael Rajesh , Subbu Perumal , Debjani Banerjee , Perumal Yogeeswari , Dharmarajan Sriram 
Published: October 2010

AbstractA variety of novel highly functionalized tetrahydropyridine derivatives is synthesized via multicomponent reactions of arylsulfonylbutanoates (I) with aromatic aldehydes and ammonium acetate and transformed into corresponding aromatics upon dehydrogenation with DDQ.
ChemInform Abstract: A Route to Alkenyl‐Substituted 4‐Hydroxypyridine and Pyrimidine Derivatives via Three‐Component Access to β‐Alkoxy‐β‐ketoenamides.
Authors: Bera Mrinal K. , Reissig Hans‐Ulrich 
Published: October 2010

AbstractThe title reaction affords β‐keto enamides (IV).
ChemInform Abstract: Polycyclic N‐Heterocyclic Compounds. Part 64. Synthesis of 5‐Amino‐1,2,6,7‐tetrahydrobenzo[f]furo[2,3‐c]isoquinolines and Related Compounds. Evaluation of Their Bronchodilator Activity and Effects on Lipoprotein Lipase mRNA Expression.
Authors: Okuda Kensuke , Deguchi Hiroshi , Kashino Setsuo , Hirota Takashi , Sasaki Kenji 
Published: October 2010

AbstractA method for the synthesis of benzo‐fused 5‐aminocycloalkeno[1,2‐d]furo[2,3‐b]pyridines (IV) via Truce—Smiles rearrangement is developed.
ChemInform Abstract: New Pyrrolo[1,2‐b]pyridazine Derivatives.
Authors: Dumitrascu Florea , Draghici Constantin , Caproiu Miron T. , Dumitrescu Dan G. , Popa Marcel Mirel 
Published: October 2010

AbstractThe title compounds (IV) (7 examples) are regioselectively obtained in a three‐component one‐pot reaction between pyridazine (I), phenacyl bromides (II), and 1‐butyn‐3‐one (III) in the presence of 1,2‐epoxybutane as reaction medium and acid scavenger.
ChemInform Abstract: Synthesis of Fused Pyrimidone Derivatives of 4‐Pyrones from the Acetates of Baylis—Hillman Adducts (V).
Authors: Shahrisa A. , Ghasemi Z. 
Published: October 2010

AbstractTitle compounds (VII) and (IX) are synthesized starting by Baylis—Hillman reaction of formylpyrones (I) under convenient conditions.
ChemInform Abstract: Microwave‐Assisted One‐Pot Synthesis of Octahydroquinazolinone Derivatives Using Ammonium Metavanadate under Solvent‐Free Condition.
Authors: Niralwad Kirti S. , Shingate Bapurao B. , Shingare Murlidhar S. 
Published: October 2010

AbstractThe readily available inexpensive catalyst renders possible a rapid and efficient access to the biologically interesting skeleton.
ChemInform Abstract: Highly Efficient Synthesis of 2,3‐Dihydroquinazolin‐4(1H)‐ones Catalyzed by Heteropoly Acids in Water.
Authors: Zong YingXiao , Zhao Yan , Luo WenCai , Yu Xing Hai , Wang Jun Ke , Pan Yi 
Published: October 2010

AbstractH3PW12O40 is described as highly for efficient the condensation of anthranilamides with aromatic aldehydes.
ChemInform Abstract: A Convenient Synthesis of Quinazoline Derivatives via Cascade Imino‐Diels—Alder and Oxidation Reaction.
Authors: Chen Xue Ming , Wei Hui , Yin Lu , Li Xing Shu 
Published: October 2010

AbstractThe reaction occurs between 2 α‐iminoesters, which can be generated in situ from anilines and ester (II) or introduced directly.
ChemInform Abstract: Heteroannulated Quinazoline and Quinazolinone Derivatives from (Z)‐2‐[1‐Benzamido‐2‐(3,4,5‐trimethoxyphenyl)] vinyl‐3,1‐benzoxazin‐4(3H)‐one.
Authors: Mahmoud Mahmoud R. , Derbala Hamed A. Y. 
Published: October 2010

AbstractBenzoxazinone (I) reacts with different nitrogen nucleophiles leading to various quinazoline and quinazolinone derivatives.
ChemInform Abstract: Concise Two‐Step Solution Phase Syntheses of Four Novel Dihydroquinazoline Scaffolds.
Authors: Dietrich Justin , Kaiser Christine , Meurice Nathalie , Hulme Christopher 
Published: October 2010

AbstractUgi four‐component reaction of mono N‐Boc protected o‐aminobenzylamines such as (I) and following acid catalyzed dehydrative cyclization offers a simple route to different types of pharmaceutically important title scaffolds.
ChemInform Abstract: Diversity‐Oriented Synthesis of Dibenzoazocines and Dibenzoazepines via a Microwave‐Assisted Intramolecular A3‐Coupling Reaction.
Authors: Bariwal Jitender B. , Ermolat'ev Denis S. , Glasnov Toma N. , Van Hecke Kristof , Mehta Vaibhav P. , Van Meervelt Luc , Kappe C. Oliver , Van der Eycken Erik V. 
Published: October 2010

AbstractThe method allows the introduction of five different points of diversity in the products.
ChemInform Abstract: Ethynyl MIDA Boronate: A Readily Accessible and Highly Versatile Building Block for Small Molecule Synthesis.
Authors: Struble Justin R. , Lee Suk Joong , Burke Martin D. 
Published: October 2010

AbstractEthynyl N‐methyliminodiacetic acid boronate (I) is successfully applied in the regioselective iterative synthesis of arylethyne (III) and tolan derivatives, e.g. (IV).
ChemInform Abstract: Diversity‐Oriented Synthesis of Disubstituted Alkenes Using Masked Silanols.
Authors: Sore Hannah F. , Blackwell David T. , MacDonald Simon J. F. , Spring David R. 
Published: October 2010

AbstractThe preparation methods for the (E)‐ and α‐disubstituted alkenes are developed using the reaction of pentafluorodimethylsilane (I) and alkynes (II) with the proper choice of a catalyst, yielding the corresponding pentafluorodimethylvinylsilanes, and the following cross‐coupling reaction with the aryl iodides [cf.
ChemInform Abstract: Synthesis of β‐Aminovinylphosphonates by Organocatalytic Nucleophilic Displacement of Acetate with Amines.
Authors: Garzon Cecile , Attolini Mireille , Mafei Michel 
Published: October 2010

AbstractA broad spectrum of structurally diverse amines reacts with vinyl phosphonate (I) to give important building blocks.
ChemInform Abstract: Catalytic Enantioselective Total Syntheses of Bakkenolides I, J, and S: Application of a Carbene‐Catalyzed Desymmetrization.
Authors: Phillips Eric M. , Roberts John M. , Scheidt Karl A. 
Published: October 2010

AbstractThe key step of the synthesis of bakkenolides S (III), I (IVa) and J (IVb) is a tandem homoenolate protonation, intramolecular aldol addition and acylation of (I), catalyzed by an N‐heterocyclic carbene (MTC).
ChemInform Abstract: α‐Glucosidase Inhibition Properties of Cucurbitane‐Type Triterpene Glycosides from the Fruits of Momordica charantia
Authors: Kim Young Ho , et al. et al. 
Published: October 2010

Abstractisolation, structure elucidation and biological activities of fourteen cucurbitane‐type triterpene glycosides, including three new compounds named charantosides A—C (I)—(III)
ChemInform Abstract: Five New Triterpene Bisglycosides with Acyclic Side Chains from the Rhizomes of Cimicifuga foetida L.
Authors: Lu Lu , Chen Jian‐Chao , Song He‐Jiao , Li Yan , Nian Yin , Qiu Ming‐Hua 
Published: October 2010

Abstractisolation, structure and cytotoxicity of one lanostane bisglycoside, foetidinoside A (I), one seco‐cycloartane type bisglycoside, foetidinoside B (II), and three new cycloartane‐type bisglycosides, foetidinoside C (III), D and E
ChemInform Abstract: Transformation of 5,8‐Dimethyl‐1‐tetralone: Synthesis of Ar‐occidol.
Authors: Banerjee Ajoy K. , Vera Willam J. , Cabrera Elvia V. , Sanchez Jennifer L. 
Published: October 2010

AbstractA new approach for the synthesis of ar‐occidol (VI), the aromatic analogue of naturally occurring sesquiterpene occidol is developed.
ChemInform Abstract: Trigochinins D—I: Six New Daphnane‐Type Diterpenoids from Trigonostemon chinensis.
Authors: Chen Hua‐Dong , Yang Sheng‐Ping , He Xiu‐Feng , Liu Hong‐Bing , Ding Jian , Yue Jian‐Min 
Published: October 2010

AbstractTrigochinins E (Ib) and F (Ic) exhibit a strong inhibiting activity against the HL‐60 tumor cell line.
ChemInform Abstract: Cytotoxic Cardenolides from the Leaves of Calotropis gigantea.
Authors: Seeka Chonticha , Sutthivaiyakit Somyote 
Published: October 2010

Abstract15‐β‐Hydroxycardenolides (Ia), (Ib) and 16‐α‐hydroxycalactinic acid methyl ester (Ic) are isolated from the leaves of Calotropis gigantea along with eleven known compounds.
ChemInform Abstract: Glycine Amides as PPARα Agonists.
Authors: Urbahns Klaus , Woltering Michael , Nikolic Susanne , Pernerstorfer Josef , Bischoff Hilmar , Dittrich‐Wengenroth Elke , Lustig Klemens 
Published: October 2010

AbstractAmong a variety of glycine amides, prepared as shown in the scheme, the derivative (VI) is a potent and specific glycine amide with oral bioavailability in rodents.
ChemInform Abstract: A General Approach to the Synthesis of β2‐Amino Acid Derivatives via Highly Efficient Catalytic Asymmetric Hydrogenation of α‐Aminomethylacrylates.
Authors: Guo Yujuan , Shao Guang , Li Lanning , Wu Wenhao , Li Ruihong , Li Jingjing , Song Jian , Qiu Liqin , Prashad Mahavir , Kwong Fuk Yee 
Published: October 2010

AbstractThe asymmetric hydrogenations of α‐(aminomethyl)acrylates using rhodium(Et‐DuPHOS) catalysts give the corresponding β2‐amino acids with up to <99.5% e.e.
ChemInform Abstract: Phenylethanoid and Iridoid Glycosides in the New Zealand Snow Hebes (Veronica, Plantaginaceae)
Authors: Taskova Rilka M. , Kokubun Tetsuo , Ryan Ken G. , Garnock‐Jones Phil John , Jensen Soren Rosendal 
Published: October 2010

Abstractisolation and structure determination of 33 compounds including 14 previously unknown esters of phenylethanoid glycosides named chionosides, e.g. (I), and isochionosides, e.g. (II)
ChemInform Abstract: Glycosylation from Non‐Reducing End Using a Combination of Thioglycoside and Glycosyl Sulfoxide as the Glycosyl Donor and the Acceptor.
Authors: Kajimoto Tetsuya , Arimitsu Kenji , Ozeki Minoru , Node Manabu 
Published: October 2010

AbstractA novel strategy for the synthesis of oligosaccharides is presented.
ChemInform Abstract: Synthesis of (‐)‐Paroxetine via Enantioselective Phase‐Transfer Catalytic Monoalkylation of Malonamide Ester.
Authors: Kim Mi‐hyun , Park Yohan , Jeong Byeong‐Seon , Park Hyeung‐geun , Jew Sang‐sup 
Published: October 2010

AbstractThe synthesis is achieved with the enantioselective phase‐transfer catalytic alkylation to yield (III) and the diastereoselective Michael addition affording (VI) with 96% d.e.
ChemInform Abstract: Epoxide Opening‐Induced Tandem 8‐Azabicyclo[3.2.1]octane to 6‐Azabicyclo[3.2.1]octane Rearrangement—Iminium Allylation: Synthesis of (.+‐.)‐Peduncularine.
Authors: Hodgson David M. , Shelton Ruth E. , Moss Thomas A. , Dekhane Mouloud 
Published: October 2010

AbstractThe rearrangement of (I) is promoted by TmsOTf and affords (III) in high yield.
ChemInform Abstract: Cyclic Spermidine Alkaloids and Flavone Glycosides from Meehania fargesii.
Authors: Murata Toshihiro , Miyase Toshio , Yoshizaki Fumihiko 
Published: October 2010

AbstractTwo new spermidine alkaloids, meefarnines A and B and four new flavone glycosides, fargenins A‐D (II) are isolated from the whole plant of Meehania fargesii along with ten known compounds.
ChemInform Abstract: Novoamauromine (I) and ent‐Cycloechinulin (II): Two New Diketopiperazine Derivatives from Aspergillus novofumigatus
Authors: Ishikawa Kazuki , Hosoe Tomoo , Itabashi Takeshi , Wakana Daigo , Takizawa Kayoko , Yaguchi Takashi , Kawai Ken‐ichi 
Published: October 2010

Abstractisolation, structure, antifungal and cytotoxic activities
ChemInform Abstract: One‐Pot Synthesis of the Naturally Occurring Dimeric Carbazole Alkaloid Murranimbine and Its Analogue.
Authors: Chakraborty Mumu , Mukhopadhyay Sibabrata 
Published: October 2010

AbstractBF3·OEt2‐catalyzed dimerization of girinimbine (Ia) provides title compound murranimbine (IIa) in one step.
ChemInform Abstract: New Phenylpropanoid Glycosides from Juniperus communis var. depressa.
Authors: Iida Naoki , Inatomi Yuka , Murata Hiroko , Murata Jin , Lang Frank A. , Tanaka Toshiyuki , Nakanishi Tsutomu , Inada Akira 
Published: October 2010

AbstractTwo new phenylpropanoid glycosides (I) and (II) are isolated along with several known substances from leaves and stems of the North American title plant.
ChemInform Abstract: Enantioselective Synthesis of (+)‐Patulolide C (VIIb) via Proline‐Catalyzed Sequential α‐Aminooxylation and Horner—Wadsworth—Emmons Olefination.
Authors: Sabitha Gowravaram , Chandrashekhar G. , Yadagiri K. , Yadav J. S. 
Published: October 2010

AbstractThe sequence starts with Jacobsen′s kinetic resolution.
ChemInform Abstract: Chemoenzymatic Synthesis and Cannabinoid Activity of a New Diazabicyclic Amide of Phenylacetylricinoleic Acid.
Authors: Lopez‐Ortiz Manuel , Herrera‐Solis Andrea , Luviano‐Jardon Axel , Reyes‐Prieto Nidia , Castillo Ivan , Monsalvo Ivan , Demare Patricia , Mendez‐Diaz Monica , Regla Ignacio , Prospero‐Garcia Oscar 
Published: October 2010

AbstractA chemoenzymatic synthesis of a new diazabicyclic amide (IV) of phenylacetylricinoleic acid is presented.
ChemInform Abstract: Papuabalanols A and B, New Tannins from Balanophora papuana.
Authors: Hosoya Takahiro , Nakata Asami , Zaima Kazumasa , Latip Jalifah , Din Laily Bin , Muslim Noramly , Morita Hiroshi 
Published: October 2010

AbstractPapuabalanol A (Ib) shows moderate vasodilator effect on rat aorta while papuabalanol B (Ia) shows potent inhibition of mushroom tyrosinase and anti‐melanogenesis in B16 mouse melanoma cells.
ChemInform Abstract: Discovery of 4‐{1‐[({1‐ [4‐(Trifluoromethyl)benzyl]‐1H‐indol‐7‐yl}carbonyl)amino] cyclopropyl}benzoic Acid (MF‐766), a Highly Potent and Selective EP4 Antagonist for Treating Inflammatory Pain.
Authors: Han Yongxin , et al. et al. 
Published: October 2010

AbstractThe synthesis of the second generation EP4 antagonist MF‐766 (I) is accomplished in four steps from an easily accessible methyl indolecarboxylate.
ChemInform Abstract: Azaphthalocyanines Containing Pyrazine Rings with Focus on the Alkylheteroatom, Aryl and Heteroaryl Substitution and Properties Important in Photodynamic Therapy
Authors: Zimcik Petr , Novakova Veronika , Miletin Miroslav , Kopecky Kamil 
Published: October 2010

AbstractReview: 69 refs.
Neutrophil phagocytosis by tumor cells—A cytological study
Authors: Singhal Niti , Handa Uma , Bansal Cherry , Mohan Harsh 
Published: October 2010

AbstractCell cannibalism is defined as the ability of a cell to phagocytose another cell. Malignant tumor cells may develop phagocytic property and demonstrate phagocytosis of own cells or cells of other series like neutrophils and lymphocytes. We report 11 cases in which the tumor cells showed evidence of neutrophil phagocytosis/emperipolesis on FNAC smears.Cases of malignancies diagnosed on FNA over a period of 1 year were retrieved, and smears were examined for neutrophil phagocytosis by tumor cells. These cases were classified according to type and differentiation of malignancy. The cytomorphological features and background inflammation were also studied at both primary and metastatic site.Of 362 malignant cases diagnosed on FNA smears, in 11 cases (3.09%), tumor cells showed neutrophil phagocytosis. The background showed increase in polymorphs in all cases. All the cases were associated with metastasis at presentation and were high‐grade tumors cytologically. There were three cases of anaplastic carcinoma, two cases of adenocarcinoma, two cases of carcinoma breast, two cases of anaplastic non‐Hodgkins lymphoma, one case each of squamous cell carcinoma and small cell carcinoma from larynx and lung, respectively.Phagocytic activity by tumor cells is uncommon and usually seen in high‐grade/poorly differentiated malignancies. It is frequently associated with metastatic disease. On cytology smears, true phagocytosis of neutrophils by tumor cells has to be distinguished from superimposed inflammatory cells from the background. The tumor cells also need to be distinguished from histiocytes displaying phagocytosis. Diagn. Cytopathol. 2011. © 2010 Wiley‐Liss, Inc.
Fascin stain as a potential marker of invasiveness in carcinomas of the urinary bladder: A retrospective study with biopsy and cytology correlation
Authors: McKnight Ryan , Cohen Cynthia , Siddiqui Momin T. 
Published: October 2010

AbstractThe evaluation of invasion in urothelial carcinomas of the urinary bladder cannot be determined on cytology and can be particularly challenging in biopsy cases with limited sampling. Recent studies of bladder resection specimens suggest that fascin overexpression may be a marker of aggressive urothelial carcinomas and can help facilitate the assessment of invasion. In this study, we evaluated urine cytology and corresponding biopsy specimens with proven invasive urothelial carcinoma for fascin expression by immunohistochemistry. Thirty‐five patients diagnosed with positive urine cytology and biopsy‐proven invasive urothelial carcinoma between January 2003 and February 2009 were identified. We found increased fascin expression in 100% (35/35) of SurePathTM&!trade; urine cytology preparations as well as 100% (35/35) of corresponding biopsy cases with invasive urothelial carcinoma. On urine cytology, cytoplasmic fascin staining was moderate to intense in malignant tumor cell clusters and single cells and not observed in benign urothelial cells. Staining in biopsy cases was generally intense and cytoplasmic and present in both the invasive (100%) and noninvasive (31%) components of the lesion. These findings uphold the association of increased fascin expression in invasive urothelial carcinomas of the urinary bladder. We furthermore demonstrate that fascin staining can be performed successfully on SurePathTM&!trade; urine cytology preparations in which increased fascin expression correlates with invasion on biopsy. While not a definitive marker of invasion, as it is observed in in situ carcinoma, we conclude that the utilization of fascin immunohistochemistry on urine cytology might serve as a useful adjunct in predicting invasiveness in subsequent biopsies. Diagn. Cytopathol. 2010. © 2010 Wiley‐Liss, Inc.
Core needle biopsy versus fine needle aspiration biopsy in breast—A historical perspective and opportunities in the modern era
Authors: Nassar Aziza 
Published: October 2010

AbstractBreast fine‐needle aspiration biopsy (FNAB) by palpation is on the decline, due to its limitations in diagnostic accuracy, decreased sensitivity, and its replacement with core needle biopsy (CNB). Despite its decreasing utility, superficial fine‐needle aspiration (FNA) in breast is still the main modality for evaluating metastatic lesions, recurrence, and axillary lymph node metastasis. New modalities including proteomic pattern expression and methylation profiling of breast lesions are other promising techniques that can be used as ancillary tests for refining the diagnosis of breast lesions using FNAB. Image‐guided breast FNA proves to be a successful alternative with high sensitivity and specificity. In this review, the advantages, disadvantages, and inherent limitations of breast FNA and CNB, and new advanced techniques are discussed. Diagn. Cytopathol. 2011. © 2010 Wiley‐Liss, Inc.