bluuebunny/crossref_metadata_2025_split huggingface dataset:
Commentary on ‘Interventions for treating scabies’
Authors: Le Cleach Laurence , Chosidow Olivier 
Published: November 2011

AbstractThis is a commentary of a Cochrane review, published in this issue of EBCH, first published as: Strong M, Johnstone P. Interventions for treating scabies. Cochrane Database of Systematic Reviews 2007, Issue 3. Art. No.: CD000320. DOI: 10.1002/14651858.CD000320.pub2.Further information for this Cochrane review is available in this issue of EBCH in the accompanying Summary article. Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. The Cochrane Collaboration
Commentary on ‘Probiotics for treating persistent diarrhoea in children’
Authors: Kligler Benjamin 
Published: November 2011

AbstractThis is a commentary of a Cochrane review, published in this issue of EBCH, first published as: Bernaola Aponte G, BadaMancilla CA, Carreazo Pariasca NY, Rojas Galarza RA. Probiotics for treating persistent diarrhoea in children. Cochrane Database of Systematic Reviews 2010, Issue 11. Art. No.: CD007401. DOI: 10.1002/14651858.CD007401.pub2.Further information for this Cochrane review is available in this issue of EBCH in the accompanying Summary article. Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. The Cochrane Collaboration
Commentary on ‘Probiotics for treating acute infectious diarrhoea’
Authors: Guandalini Stefano 
Published: November 2011

AbstractThis is a commentary of a Cochrane review, published in this issue of EBCH, first published as: Allen SJ, Martinez EG, Gregorio GV, Dans LF. Probiotics for treating acute infectious diarrhoea. Cochrane Database of Systematic Reviews Commentary2010, Issue 11. Art. No.: CD003048. DOI: 10.1002/14651858.CD003048.pub3.Further information for this Cochrane review is available in this issue of EBCH in the accompanying Summary article. Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. The Cochrane Collaboration
Commentary on ‘Anti‐pseudomonal beta‐lactams for the initial, empirical, treatment of febrile neutropenia: comparison of beta‐lactams’ with a response from the review authors
Authors: Sung Lillian , Paul Mical , Yahav Dafna , Leibovici Leonard 
Published: November 2011

AbstractThese are commentaries of a Cochrane review, published in this issue of EBCH, first published as: Paul M, Yahav D, Bivas A, Fraser A, Leibovici L. Anti‐pseudomonal beta‐lactams for the initial, empirical, treatment of febrile neutropenia: comparison of beta‐lactams. Cochrane Database of Systematic Reviews Commentaries2010, Issue 11. Art. No.: CD005197. DOI: 10.1002/14651858.CD005197.pub3.Further information for this Cochrane review is available in this issue of EBCH in the accompanying Summary article. Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. The Cochrane Collaboration
Summary of ‘Interactive computer‐based interventions for sexual health promotion’
Authors: Editorial Office Evidence‐Based Child Health 
Published: November 2011

AbstractThis is a summary of Cochrane review, published in this issue of EBCH, first published as: Bailey JV, Murray E, Rait G, Mercer CH, Morris RW, Peacock R, Cassell J, Nazareth I. Interactive computer‐based interventions for sexual health promotion. Cochrane Database of Systematic Reviews 2010, Issue 9. Art. No.: CD006483. DOI: 10.1002/14651858.CD006483.pub2. Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. The Cochrane Collaboration
Enzymatic and Organocatalyzed Asymmetric Aldolization Reactions for the Synthesis of Thiosugar Scaffolds
Authors: Fanton Johan , Camps Flora , Castillo José A. , Guérard‐Hélaine Christine , Lemaire Marielle , Charmantray Franck , Hecquet Laurence 
Published: November 2011

AbstractWe studied the synthesis of original thiosugar scaffolds by enantioselective aldolization. L‐Proline‐catalyzed C–C bond formation was the key step in the synthesis of L‐erythro‐thioketoses (3S,4R), whereas fructose‐6‐phosphate aldolase‐catalyzed reactions yielded the D‐threo‐thioketose series (3S,4S). By the organocatalytic approach, 5‐thio‐L‐ribulofuranose (1) and 5‐deoxy‐6‐thio‐L‐psicopyranose (2) were obtained in satisfactory overall yields from 2‐haloacetaldehydes, whereas 5‐thio‐D‐xylulofuranose (3) was synthesized in 50 % overall yield by an enzymatic aldolization reaction in only two steps from the same starting material.
High levels of hsCRP are associated with carbohydrate metabolism disorder
Authors: Leiva Elba , Mujica Verónica , Brito Katherine , Palomo Ivan , Orrego Roxana , Moore‐Carrasco Rodrigo , Vásquez Marcela , Guzmán Luis , Nuñez Sergio , Díaz Nora , Icaza Gloria , Arredondo Miguel 
Published: November 2011

AbstractAim: To determine risk parameters associated with high values of high sensitive C‐reactive protein (hsCRP) in subjects with different glucose fasting levels. Methods: Anthropometric parameters, arterial pressure, glycemia, lipid profile, uric acid, and hsCRP were studied in a population of 513 individuals between 40 and 65 years. Results: In total, 349 (68.0%) were normoglycemic (NG); 113 (22.0%) had impaired fasting glucose (IFG); and 51 (9.9%) were diabetic subjects. A multivariate linear regression analysis showed that the natural logarithm of hsCRP was associated significantly with glycemia levels (P = 0.009), uric acid (P = 0.001), diastolic blood pressure (P = 0.011), smoking habit (P = 0.021), BMI (P<0.001), and sex (P<0.001). One‐third of the NG subjects had high hsCRP levels. A multiple logistic regression analysis showed that sex and BMI were variables related to high levels of hsCRP in subjects with IFG and NG. In NG subjects, uric acid levels were associated with risk of presenting high hsCRP levels and were higher in women than men. In NG women, ROC curves analysis identified a uric acid level of 3.9 mg/dl as a cut‐off point to predict a high value of hsCRP. Those individuals with uric acid values higher than 3.9 mg/dl and normal glycemia had 3.5‐fold more risk of having hsCRP levels over 3.0 mg/l. Conclusions: We sustain that high levels of hsCRP are associated with disturbance in carbohydrate metabolism. In addition, we believe that in low cardiovascular risk population, such as NG women, uric acid levels above 3.9 mg/dl might represent a signal of possible pro‐inflammatory state and cardiovascular risk. J. Clin. Lab. Anal. 25:375–381, 2011. © 2011 Wiley Periodicals, Inc.
Latent tuberculosis infection screening for laboratory personnel using interferon‐γ release assay and tuberculin skin test in Korea: an intermediate incidence setting
Authors: Moon Hee‐Won , Kim Hanah , Hur Mina , Yun Yeo‐Min , Lee Anna 
Published: November 2011

AbstractBackground: Though recent reports have indicated a higher prevalence of latent tuberculosis infection (LTBI) in laboratory personnel than in other healthcare workers, these studies included only a limited number of laboratory personnel. Methods: We have thus focused on the laboratory personnel, who had a high level of exposure to specimens from patients with TB. We recruited 173 laboratory personnel and performed QuantiFERON‐TB Gold In‐Tube test (QFT‐G) and tuberculin skin test (TST). Results: QFT‐G was positive in 21.4% of the enrolled laboratory personnel, and TST was positive in 33.3%. The agreement between the two tests was fair (κ = 0.234). In multivariate analyses, household contactwith TBpatients (P = 0.013), the laboratory sections of microbiology (P = 0.045) and chemistry/immunology (P = 0.014) were shown to be significantly associated with positive QFT‐G results. Conclusion: Our data show a high prevalence of TST and QFT‐G positivity in laboratory personnel and emphasize the importance of LTBI screening for laboratory personnel. In BCG‐vaccinated populations with an intermediate incidence setting, QFT‐G seems to be superior to TST as a screening tool for the detection of LTBI. Further study, including results of follow‐up tests will be helpful for confirmation of our findings. J. Clin. Lab. Anal. 25:382–388, 2011. © 2011 Wiley Periodicals, Inc.
The serum profile of adipokines in naïve patients with diabetes mellitus type 2 and obesity
Authors: de Luis D.A. , Aller R. , Izaola O. , Ovalle H.F. 
Published: November 2011

AbstractBackground: The aim of this study was to explore the relationship of serum profile of adipokines with cardiovascular risk factors and anthropometric parameters in patients with diabetes mellitus type 2. Subjects: A population of 108 obese patients with DM2 was analyzed. A complete biochemical anthropometric and nutritional evaluation was performed. Results: In the analysis with leptin as a dependent variable, the IL‐6 and glucose levels remained in the model (F = 6.2; P<0.05), with an increase of 5.8 (CI 95%:2.7–7.6) ng/ml with each 1 pg/ml of IL‐6 and of 5.2 (CI95%:2.5–5.8) ng/ml with each 1 mg/dl of glucose. In a second model with adiponectin as a dependent variable, the BMI remained in the model (F = 3.77;P<0.05), with an decrease of −3.77 (CI 95%:0.53–7.1) ng/ml with each 1 point of BMI. In the third multivariate analysis with IL‐6 as a dependent variable, the glucose level remained in the model (F = 10.1; P<0.01), with an increase of 0.09 (CI95%:0.06–0.12) pg/ml with each 1 mg/dl of glucose. In the fourth multivariate analysis with resistin as a dependent variable, the CRP remained in the model (F = 2.51; P<0.05), with an increase of 0.28 (CI 95%:0.08–0.48) pg/ml with each 1 mg/dl of CRP. Conclusion: Serum profile of adipokines is associated with different risk factors in diabetic obese patients. J. Clin. Lab. Anal. 25:409–413, 2011. © 2011 Wiley Periodicals, Inc.
Glutathione S‐transferase gene polymorphisms are not major risks for susceptibility to posttransplantation diabetes mellitus in Taiwan renal transplant recipients
Authors: Tsai Jen‐Pi , Yang Shun‐Fa , Wu Sheng‐Wen , Hung Tung‐Wei , Tsai Hui‐Ching , Lian Jong‐Da , Chang Horng‐Rong 
Published: November 2011

AbstractGlutathione S‐transferase (GST) M1 null genotype has been reported playing a significant role in the diabetes mellitus (DM) susceptibility in Turkish population. We investigated whether the GSTM1, GSTA1, and GSTP1 gene polymorphisms are associated with posttransplantation diabetes mellitus (PTDM) in Taiwan. There were 283 renal transplant recipients (RTRs) enrolled. Polymerase chain reaction–restriction fragment length polymorphism was used for the measurement of GSTA1, M1, and P1 genetic polymorphisms. PTDM was diagnosed according to the American Diabetes Association guidelines. Eight‐five patients (30%) were diagnosed with PTDM. The averaged posttransplant follow‐up period was 77.9 ± 27.2 months. Duration from transplantat to diagnosis of PTDM ranged from 0.2 to 103.1 months (19.2 ± 26.3 months). There were significantly differences between non‐DM and PTDM groups in age (50.6 ± 11.0 vs. 54.6 ± 9.36 years, P = 0.005), BMI (22.4 ± 3.6 vs. 24.3 ± 3.8, P<0.001). The distributions of GSTA1, GSTP1, and GSTM1 genotypes alleles were not significantly different between PTDM and non‐DM group. Patients carrying the different GSTA1, GSTP1, and GSTM1 genetic and allelic polymorphisms had no differences for the development of PTDM. These overall results suggested a lack of strong association with GSTA1, GSTP1, and GSTM1 genetic polymorphisms to the susceptibility of PTDM in Taiwanese RTRs. J. Clin. Lab. Anal. 25:432–435, 2011. © 2011 Wiley Periodicals, Inc.
Post‐discharge intervention in vulnerable, chronically ill patients
Authors: Kansagara Devan , Ramsay Rebecca S. , Labby David , Saha Somnath 
Published: November 2011

AbstractBACKGROUND:Studies suggest that the inpatient to outpatient transition of care is a vulnerable period for patients, and socioeconomically disadvantaged populations may be particularly susceptible.OBJECTIVE:In this prospective cohort study, clustered by hospital, we sought to determine the feasibility and utility of a simple, post‐discharge intervention in reducing hospital readmissions.METHODS:Chronically ill Medicaid managed care members were consecutively identified from the discharge records of 10 area hospitals. For patients from the 7 intervention hospitals, trained medical assistants performed a brief telephone needs assessment, within 1 week of discharge, in which issues requiring near‐term resolution were identified and addressed. Patients with more complicated care needs were identified according to a 4‐domain care needs framework and enrolled in more intensive care management. Patients discharged from the 3 control hospitals received usual care. We used a generalized estimating equation model, which adjusts for clustering by hospital, to evaluate the primary outcome of hospital readmission within 60 days.RESULTS:There were 97 intervention and 130 control patients. Intervention patients were slightly younger and had higher adjusted clinical group (ACG) scores. In unadjusted analysis, the intervention group had lower, but statistically similar, 60‐day rehospitalization rates (23.7% vs 29.2%, P = 0.35). This difference became significant after controlling for ACG score, prior inpatient utilization, and age: adjusted odds ratio (OR) [95% confidence interval (CI)] 0.49 [0.24‐1.00].CONCLUSIONS:A simple post‐discharge intervention and needs assessment may be associated with reduced recurrent hospitalization rates in a cohort of chronically ill Medicaid managed care patients with diverse care needs. Journal of Hospital Medicine 2012;. © 2011 Society of Hospital Medicine
Incidence of hypoglycemia following insulin‐based acute stabilization of hyperkalemia treatment
Authors: Schafers Stephen , Naunheim Rosanne , Vijayan Anitha , Tobin Garry 
Published: November 2011

AbstractPURPOSE:The aim of this study was to assess the incidence of hypoglycemia in hospitalized patients following acute treatment of hyperkalemia with insulin. A characterization of the affected patients and the administered insulin/dextrose regimens was also performed.METHODS:A retrospective search of the electronic records of a large university‐based tertiary care hospital was conducted, from June 1, 2009 to December 1, 2009, to identify patients who developed hypoglycemia following acute stabilization of hyperkalemia treatment with regular insulin.RESULTS:Of 219 hyperkalemic patients who met the criteria of the study, 19 patients (8.7%) were identified as hypoglycemic (blood glucose <70 mg/dl), and 5 of these patients (2.3% of study patients) were classified as severely hypoglycemic (blood glucose <40 mg/dl). Fifteen (79%) of the hypoglycemic patients had acute kidney injury or were end‐stage renal disease patients on hemodialysis at the time of treatment. Fifty‐eight percent of the hypoglycemic events occurred following the commonly employed 10 units of regular insulin and 25 gm of dextrose 50% treatment regimen.CONCLUSION:Iatrogenic hypoglycemia, as a result of treatment for hyperkalemia, is a common occurrence. Hyperkalemia occurs disproportionately in patients with acute kidney injury or end‐stage renal disease, and these patients are predisposed to an increased risk of hypoglycemia. The risk of severe hypoglycemia escalates in patients with lower body weight and creatinine clearance. Hypoglycemia risk can be minimized by providing sufficient dextrose in the treatment regimen, however, patient variability in treatment response dictates careful blood glucose monitoring before and after treatment. Journal of Hospital Medicine 2011;. © 2011 Society of Hospital Medicine.
Low Versus High Sensation‐seeking Tourists: a Study of Backpackers' Experience Risk Perception
Authors: Fuchs Galia 
Published: November 2011

ABSTRACTThis study investigates the relationships between the personality trait of sensation seeking and backpackers' risk perceptions by relying on a survey of 579 Israeli students who experienced backpacking. Some of the findings suggest that sensation seeking and travel risk perceptions are negatively correlated. For example, backpackers who were characterized as high social stimulus seekers were less concerned with socially oriented threats, such as crowded and commercialized places. However, other findings indicate that the relationships between the two concepts are more complex and might not be negatively correlated. For instance, the findings also indicate that the respondents were concerned about risks they were most likely to confront, given their anticipated behavior and nature of experiences that might be determined by their personality trait of sensation seeking. Copyright © 2011 John Wiley & Sons, Ltd.
Endoscopic anatomy of the palatovaginal canal (palatosphenoidal canal)
Authors: Pinheiro‐Neto Carlos D. , Fernandez‐Miranda Juan C. , Rivera‐Serrano Carlos M. , Paluzzi Alessandro , Snyderman Carl H. , Gardner Paul A. , Sennes Luiz U. 
Published: November 2011

AbstractObjectives/Hypothesis:Demonstrate the endoscopic anatomy of the palatovaginal (PV) canal and artery for identification and dissection of the vidian nerve during endoscopic transpterygoid approaches. Evaluate the length of the PV canal and its relation with the vidian nerve. Show that the traditionally known PV canal is a misnomer and should be renamed.Study Design:Experimental study: anatomical and radiological.Methods:Dissection of eight cadaveric heads was performed to demonstrate the endoscopic anatomy of the PV canal. Computed tomography scan analysis of 20 patients was used to evaluate the length of the PV canal, the angle formed between this canal and the vidian nerve, and the distance between the vidian canal and the PV canal. Study of 10 dry skull bases was performed to verify the structures involved in the formation of the PV canal.Results:Anatomic steps and foundations for dissection of the vidian nerve using the PV canal as a landmark were described. The mean length of the PV canal was 7.15 mm. The mean proximal distance between the vidian and the PV canal was 1.95 mm, and the mean distal distance was 4.14 mm. The mean angle between those canals was 48 degrees. The osteology study showed the vaginal process of the sphenoid bone did not contribute to the formation of the PV canal.Conclusions:Our anatomic investigations, radiologic studies, and surgical experience demonstrate the important anatomic relationship of the PV canal with the vidian canal and the relevance of the PV canal as a surgical landmark in endoscopic endonasal transpterygoid approaches. Anatomically, PV canal is a misnomer and should be replaced with palatosphenoidal canal.
Production of lysophospholipids rich in DHA
Authors: Pencreac'h Gaëlle , Ergan Françoise , Poisson Laurent 
Published: November 2011

AbstractLysophospholipids (LPLs) play crucial biological roles, mainly as signaling molecules and are widely used as emulsifiers in the food and pharmaceutical industries. Docosahexaenoic acid (DHA) is an important polyunsaturated fatty acid of the omega 3 family with involvement in health now clearly proved. In cells and in blood DHA is mainly esterified on phospholipids and LPLs. The production of DHA‐rich LPLs may therefore be of great relevance to lipid biochemistry as well as industrial applications. Starting from phospholipids obtained from convenient sources, DHA‐rich LPLs can be obtained by lipase‐catalyzed deacylation of the sn‐1 position. Attention must be paid to the possible intramolecular migration of the remaining acyl moiety occurring during enzymatic reaction, purification or storage.
Co2 laser turbinectomies for chronic, obstructive rhinitis
Authors: Mittelman Harry 
Published: November 2011

AbstractA CO2 laser approach to partial inferior nasal turbinectomies for patients with severe, obstructive, chronic, perennial rhinitis that is refractory to nonsurgical therapeutic regimens is presented. CO2 laser vaporization of the anterior one fourth to one half of the inferior turbinate was done under topical and local anesthesia, as an office outpatient procedure. It does not require nasal packing. It allows the patient to return to his daily routine upon completion of the procedure. Along with these advantages, bleeding risks are decreased compared to conventional nasal turbinectomy techniques.
The establishment of precise physical parameters for the treatment of the port wine stain with the argon laser
Authors: Carruth J.A.S. 
Published: November 2011

AbstractThe use of the argon laser in the treatment of the port wine stain is discussed and its mode of action and the features of a port wine stain, which may be used to predict a good response to therapy, are described.Reference is made to the wide variation in techniques used in treatment in different centers and the need to establish precise physical parameters for therapy is stressed.An attachment to the standard handpiece is described that will enable accurate power densities to be recorded.
The clinical use of CO2 laser beam in the surgery of kidney parenchyma
Authors: Barzilay Benjamin , Lijovetzky Graciela , Shapiro Amos , Caine Marco 
Published: November 2011

AbstractEncouraged by the experimental work done on 40 kidneys in 20 dogs using the CO2 laser beam for partial nephrectomies, we decided to use the laser in four patients. Three of them underwent lower partial nephrectomy, and the fourth underwent bivalving of kidney through the anatrophic line. The use of this new instrument was very helpful in reducing blood loss, shortening the time of hemostasis, and minimizing parenchymal damage. Case No. 1 is the first published case of xanthogranulomatous pyelonephritis that underwent partial nephrectomy with success.
Assessment of the transforming potential of novel anaplastic lymphoma kinase point mutants
Authors: McDuff Fiona K.E , Lim Su‐Vern , Dalbay Melis , Turner Suzanne D. 
Published: November 2011

AbstractAnaplastic lymphoma kinase (ALK) has emerged as an important oncogene in a number of human malignancies ranging from non‐Hodgkin lymphoma to neuroblastoma. In the former case, ALK is activated as a consequence of a chromosomal translocation and in the latter due to point mutations. In both cases the transforming potential of these oncogenic forms of ALK have been shown in vitro employing traditional cellular transformation assays including 3T3 foci formation. We reasoned that other ALK mutants which have been identified by the Cancer Genome Project may likewise possess transformation potential. We have selected seven ALK mutants identified in cell lines representative of a variety of human cancers based on position within the ALK protein, zygosity and frequency of detection including R1192Q, K1525E, C1021Y, R412C, A1252V, D1311A, K1518N and have compared their transformation capability in comparison to the published neuroblastoma‐associated F1174L ALK mutant when expressed in immortalized p53−/− murine embryonic fibroblasts. Whilst the F1174L mutant reproducibly drives foci formation in vitro, the other ALK mutants fail in this task. Furthermore, apart from the F1174L ALK mutant, the ALK protein is not phosphorylated on tyrosine residue 1604 suggesting that they are kinase‐inactive in this cellular context. We conclude that not all ALK mutants have transformation potential and may represent “passenger” mutations in the evolution of cancer. © 2011 Wiley Periodicals, Inc.