bluuebunny/crossref_metadata_2025_split huggingface dataset:
Moscatilin Reverses EMT Progression and its Resulting Enhanced Invasion and
Migration by Affecting the TGF-β Signaling Pathway in Bladder Cancer
Authors: Li Zhihao , Yang Jin , Chen Lin , Chen Pei , Liu Chenhuan , Long Xiaoming , Chen Bo , Long Jun 
Published: May 2024

Background:
Bladder cancer metastasis is an essential process in the progression of muscle-invasive
bladder cancer. EMT plays a crucial role in facilitating the spread of cancer cells. Identifying compounds that can
inhibit these abilities of cancer cells is a significant international endeavor.

Objective:
To explore the migration and invasion effect of Moscatilin on the bladder and clarify the mechanism
of action

Methods:
The anti-bladder cancer effect of Moscatilin was observed by a cell proliferation experiment. The migration
and invasion of bladder cancer cells inhibited by Moscatilin were detected by Transwell and Wound healing.
The effects of Moscatilin on EMT-related proteins E-cadherin, N-cadherin, Snail1, Vimentin, and TGF-β
signaling pathways were detected by Western blot, and nucleic acid levels were verified by qPCR.

Results:
Our study revealed that Moscatilin reduced the viability of bladder cancer cells in vitro and impeded
their migration and invasion in experimental settings. Furthermore, we observed that Moscatilin decreased the
activation levels of active proteins, specifically Smad3, Samd2, and MMP2. Additionally, we found that moscatilin
significantly reduced the expression level of TGF-β and was also capable of reversing the overexpression
effect of TGF-β. Treatment with Moscatilin also led to significant inhibition of interstitial cell markers Ncadherin
and Snail1, which are associated with EMT.

Conclusion:
These findings indicate that Moscatilin impedes the migration and invasion of bladder cancer cells
by influencing cell survival, modulating TGF-β/Smad signaling, and inhibiting EMT.
Current Status and Development Trends of Morphing Wing of Aircraft
Authors: Yan Farui , Han Lu , Yang Yongqi , Xie Xuedong , Xie Baocheng 
Published: May 2024

Abstract::
Aircraft morphing wings, also known as adaptive wings or shape-variable wings, represent
a revolutionary development in the field of aerospace engineering. Inspired by the adaptability
observed in birds and insects during flight, researchers have been exploring potential applications of
morphing wing technology to enhance the performance and efficiency of aircraft. This innovative
technology holds the promise of improving aerodynamic efficiency, reducing fuel consumption, and
enhancing overall flight maneuverability. This manuscript aims to explore and analyze the potential
applications and effects of morphing wing technology for aircraft. Furthermore, this paper aims to
gain an in-depth understanding of the principles and implications of morphing wing technology for
aircraft and to assess its potential advantages in terms of flight performance, handling characteristics,
and energy efficiency. Based on different driving mechanisms, patents related to aircraft morphing
wings were systematically categorized and summarized, highlighting the most typical intra-wing and
extra-wing deformations. Through an examination of patents related to aircraft morphing wings,
various morphing wing technologies' unique characteristics were summarized. A comparative analysis
of different deformation methods revealed their respective strengths and limitations. The paper
concludes with a summary of current technical challenges facing morphing wing technology and a
forward-looking exploration of its future trends and directions. Categorizing aircraft morphing wings
into intra-wing and extra-wing deformations based on the method of deformation, this paper elaborates
on the operational principles, advantages, and limitations of these two categories. Compared to
traditional fixed wings, morphing wings exhibit superior flight performance, and it is anticipated that
more patents will be developed in the future.
Full-Mouth Rehabilitation Using Combined Multiunit Abutment and Screw-Retained T-Base Abutment System: A Case Report with 24-Month Follow-up
Authors: Albadani Mohammed Mansoor , Alahmari Manea Musa M. , Alahmari Maram A. , Al Makramani Bandar M.A. , Aldhorae Khalid , Al Moaleem Mohammed M. 
Published: May 2024

Introduction
The application of a multiunit abutment system in combination with a screw-retained T-base abutment for the all-in-six restoration of dental arches is considered a successful treatment for the maxillary and mandibular arches with implant-supported fixed prostheses.

Case Report
This case report presents the successful use of a multiunit abutment system combined with a screw-retained T-base abutment to support all-in-six implant-supported fixed prostheses in maxillary arches. Meticulous treatment planning and execution resulted in predictable and favourable outcomes after implant-supported fixed prostheses were applied to a patient exhibiting a partially maxillary arch with mobile grade III bilateral canines.

Conclusion
The treatment protocol, prosthetic components, and clinical and radiographic outcomes after the final restoration were excellent after 24 months.
A Study on the Correlation between the Expression of a Cysteine Protease, Cathepsin L, and its Inhibitor, Cystatin A, in Oral Lichen Planus
Authors: Talungchit Sineepat , Pongpanich Nantreda , Jirawechwongsakul Pimporn , Hirunwidchayarat Worawalun , Taebunpakul Patrayu 
Published: May 2024

Background
Cathepsin L (Cat-L), a cysteine protease, and cystatin A (Cys-A), a cysteine protease inhibitor, are known to be involved in Oral Lichen Planus (OLP). The imbalance in expression between these two proteins may favor OLP pathogenesis.

Objective
This study aimed to evaluate the correlation between the expression of Cat-L and Cys-A in OLP.

Methods
Thirty specimens of OLP and 30 specimens of normal tissue were used for immunohistochemistry. The pattern of cell staining, number of positive cells, and cell staining intensity were recorded. An Immunoreactive Score (IRS) was also assigned.

Results
Cat-L and Cys-A were found in all OLP specimens. In the control group, Cat-L and Cys-A were demonstrated in 83.33% and 96.67% of cases, respectively. Cat-L was primarily seen in the stratum basale in the OLP and control groups. In contrast, Cys-A expression was seen in the whole epithelium in both groups, and the intensity was lowest in the stratum basale. The percentage of positive cells, score of positive cells, staining intensity, and IRS of Cat-L and Cys-A were significantly higher in OLP than in control specimens (p < 0.05). Interestingly, a positive correlation between Cat-L and Cys-A was found in the control group but not in the OLP group.

Conclusion
The expressions of Cat-L and Cys-A were significantly higher in OLP tissues compared to normal tissues. The alterations in expression of the Cat-L cysteine protease and its Cys-A inhibitor in OLP may indicate that these two proteins play a role in the pathogenesis of OLP.
Mineral Composition of Blackcurrant (Ribes Nigrum L.) Fruits and Leaves
Authors: Struk Oksana , Starchenko Galyna , Koshovyi Oleh , Stremoukhov Oleksandr , Klymenko Yurii , Raal Ain 
Published: May 2024

Background
Plants as living systems are characterized by the appropriate degree of accumulation of macro- and microelements, which, acting as factors of the external environment, are basic modulators for synthesizing biologically active substances. Blackcurrant (Ribes nigrum L., Grossulariaceae) is widespread worldwide. Berries, leaves, and buds are medicinal raw materials in folk medicine. The regularity of inorganic elements accumulation in this plant and their impact on the quality of raw materials are topical and need to be studied.

Aims
This work aimed to study the mineral composition of R. nigrum raw materials collected in Western Ukraine (Ivano-Frankivsk and Ternopil regions) and find the regularity of their accumulation in the plant parts and from the soils.

Methods
The elemental compositions of R. nigrum fruits and leaves, as well as the soils of the growth places, were studied using the method of atomic emission spectrometry with inductively coupled plasma iCAP 7000 Duo.

Results
The content of 19 inorganic elements in R. nigrum raw materials was established. Their quantities don’t differ significantly depending on the growth places. All the fruits had high K, Na, Mg, P, and Ca contents, which were slightly lower in leaves. Thus, the fruits contain 590-675 mg/kg of Mg, while in leaves, there are just 98-106 mg/kg. Most of Fe was accumulated in the fruits (73-85 mg/kg). The content of Mn was observed in the leaves (57-64 mg/kg), slightly higher than in the fruits (47-51 mg/kg). The content of heavy metals in the objects was within the permitted limits of European Pharmacopeia. The results testify to the inverse relationship between the content of most elements in the soils and the coefficient of their accumulation in the plant.

Conclusion
The content of macro- and microelements in R. nigrum fruits and leaves had similar profiles but differed in their quantitates. The regularity of element accumulation in R. nigrum raw materials corresponds to the following profile in accordance with their quantitative content in the raw materials: K> Na> P> Mg> Ca> Si> Fe> Mn> Al> Se> Zn> Cu> Co> I> Pb> Ni> Mo> Sr> Cd. The regularity of their accumulation in the plant parts from the soils was established.
Neurological symptomatology features in patients with spine and spinal cord trauma at the thoracolumbar junction level
Authors: Nekhlopochyn O.S. , Verbov V.V. , Cheshuk Ie.V. , Vorodi M.V. 
Published: May 2024

Background. Traumatic injuries to the thoracolumbar junction account for over 60 % of all injuries to the thoracolumbar spine. The neurological symptomatology accompanying injuries at this level is characterized by diverse patterns of both motor and sensory dysfunction, which are determined by the topographic-anatomical features of this area. Neurological deficit may be caused by conductive, segmental, and radicular disturbances. The aim of the study is to determine the nature and frequency of neurological disorders in patients with spine and spinal cord trauma at the level of the thoracolumbar junction, depending on the likely substrate of the traumatic impact. Materials and methods. An analysis of the neurological status assessment was conducted in 101 patients who suffered spine and spinal cord trauma at the level of the thoracolumbar junction. The average age of the patients was 41 years (95% confidence interval 36–44). Most patients were male (75.25 %). The number of motor segments with signs of upper and lower motor neuron lesion, and dermatomes with sensory impairment of radicular, segmental, or conductive types were determined. Results. It was found that 83.5 % of motor segments with dysfunction had clinical signs of lower motor neuron lesion, 41.3 % of dermatomes with sensory impairment had traumatic root damage, 57.9 % of dermatomes showed impairments of a segmental type, and 28.9 % were of a conductive type. Conclusions. The data obtained indicate a significant role of segmental disturbances in forming the symptoms in patients with spine and spinal cord trauma at the level of the thoracolumbar junction.
Agenesia y displasia renal simultáneas en una hembra pitbull
Authors: Torres García Iván Augusto , García Ortuño Luis Enrique , Rivera Colín Diana , Salas Garrido Carlos Gerardo , Germán Tavares Ian Eduardo 
Published: May 2024

Descripción del caso. Perro hembra de raza pitbull terrier americano, de nueve meses de edad que presentaba vómito esporádico, diarrea crónica, hiporexia y pér­dida de peso.
Hallazgos clínicos. En el examen físico general, las alteraciones más significativas fueron una condición corporal 2 de 5, deshidratación del 6 %, turgencia de la piel ligeramente retardada y temperatura de 40.2 °C. Pruebas de laboratorio. Las alteraciones de laboratorio más relevantes fueron anemia por disminución de producción secundaria a insuficiencia renal crónica, hiperazotemia renal, así como proteinuria renal. Tratamiento y evolución. La evolución clínica del paciente no fue favorable, por lo que se decidió realizar eutanasia. La necropsia evidenció agenesia renal izquierda, cambios asociados a displasia renal derecha, contenido proteico en los túbulos renales, así como intususcepción ecocólica.Relevancia clínica. Las afecciones renales en perros jóvenes son raras, sin embargo, el adecuado abordaje en conjunto con pruebas clínicas y de laboratorio permiten la caracterización clínico-patológica de alteraciones del desarrollo y tienen alto valor en el pronóstico en el manejo médico. Hasta el momento, no se ha reportado la presencia de dos nefropatías concomitantes en perros juveniles, por lo que la revisión de este caso clínico permitirá un avance en el conocimiento clínicopatológico de estas afecciones.
Interplay Between Minerals in Bottled Water and Fluoride Toothpaste and Caries Lesion Remineralization
Authors: Qaw M , Al Dehailan L , Hara AT , Eckert GJ , Lippert F 
Published: May 2024

SUMMARY

Objectives:
he aim of this in vitro study was to evaluate the effects of some bottled waters on fluoride toothpaste efficacy in enhancing caries lesion remineralization.

Methods:
Early caries lesions were created in bovine enamel specimens and stratified into treatment groups based on Vickers surface microhardness (VHN). The present study followed a two (fluoride and fluoride-free toothpaste) by five (four bottled waters and tap water) factorial design. The treatment groups were bottled water with the following attributes: (a) 309.9 ppm Ca/1.20 ppm F; (b) 118.4 ppm Ca/0.16 ppm F; (c) 1.00 ppm Ca/1.01 ppm F; and (d) 0.1 ppm Ca/0.04 ppm F and tap water (48.7 ppm Ca/0.7 ppm F). The five water groups were paired either with 1100 ppm fluoride or fluoride-free toothpaste, yielding 10 groups. Specimens were pH-cycled for 10 days with the daily regimen comprised of twice daily toothpaste slurry, with four exposures to water in between. VHN was measured again and the difference was calculated (ΔVHN). Data were analyzed using two-way ANOVA at a 5% significance level.

Results:
The two-way interaction between water and toothpaste was significant (p&lt;0.001). All groups except fluoride-free toothpaste/bottled water with 0.1 ppm Ca/0.04 ppm F (p=0.411) had significant increases in VHN after pH cycling (p≤0.023). Fluoridated toothpaste resulted in a higher rate of remineralization compared to fluoride-free toothpaste (all p&lt;0.001). Bottled water with 1.20 ppm F/309.9 ppm Ca exhibited the greatest extent of remineralization within fluoride toothpaste groups (p&lt;0.001) and higher remineralization than lower fluoride water in fluoride-free toothpaste groups (p≤0.006). Within the fluoridated toothpaste group, tap water exhibited significantly less remineralization than all bottled waters (all p&lt;0.001).

Conclusion:
Within the limitation of this study, bottled water with higher fluoride and calcium concentrations might improve fluoridated toothpaste efficacy by enhancing remineralization of early enamel caries-like lesions.
IMPLEMENTASI METODE FISHERFACE DALAM PENGENALAN WAJAH MENGGUNAKAN ALGORITMA KNN
Authors: Fiardin Tsintani Tisaga , Rohman Arif Nur , Hartanto Anggit Dwi 
Published: May 2024

Sistem pengenalan wajah sekarang ini begitu dibutuhkan dan mempunyai peran sangat penting, seperti untuk keamanan, identifikasi wajah, dan lain-lain. Sistem bekerja dengan membandingkan citra wajah yang berada didatabase yang nantinya dipilih mana yang paling cocok dengan citra wajah yang diuji, dan keluaran dari dikenali atau tidaknya wajah tersebut yaitu jika citra wajahnya berada dalam database (dataset) dan nantinya ditampilkan berupa gambar wajahnya dan nama atau identitas dirinya. Adanya suatu aplikasi pengenalan wajah ini sangatlah membantu untuk pekerjaan. Dalam penelitian kali ini mencoba untuk mebuat aplikasi tersebut, dan juga belajar atau memahami alur kerja dari aplikasi ini. Proses ini menggunakan metode fisherface dengan menggunakan metode KNN, yang mana semua gambar dari dataset dikumpulkan dan didekomposisi menjadi grayscale kemudian dataset tersebut dilatih dan diklasifikasikan menggunakan KNN. Pada pengujian ini menggunakan 60 citra wajah berbeda sebagai data latih dan 40 citra wajah berbeda-beda sebagai data uji. Hasil dari ini mendapat prosentasi keberhasilan 92,5%.
The essence and features of enterprise solvency management in modern conditions
Authors: Smagina M. N. , Moskalenko N. V. , Kazantseva N. N. 
Published: May 2024

Cash is an integral part of the functioning of any enterprise, and the movement of money makes it possible to analyze the two most important indicators of any enterprise — liquidity and solvency. The potential negative consequences associated with the possibility of the next phase of the global financial crisis unfolding are reinforced by the presence of systemic contradictions in the national economy. The consequence of this is a decrease in the level of solvency of Russian enterprises, which undermines investor confidence in them.The subject of the research in the article is the theoretical and methodological foundations and practical aspects of enterprise solvency management.
The Ideal Concept of The Selection of The Republic of Indonesia in The Regulation of The Republic of Indonesia
Authors: Burlian Paisol , Heri Jhon , Putri Conie Pania 
Published: May 2024

Objective: This study aims to analyze the position of the Prosecutor in Indonesia in the current state administration.

Method: With the formal legal method, data on the Prosecutor's Office is comprehensively reviewed. Law Number 16 of 2004 which emphasizes the position of prosecutors as functional officials who are authorized by law to act as public prosecutors and executors of court decisions that have obtained permanent legal force and other powers based on the law.

Results and Discussion: The result of this research find that the Prosecutors' Office is one of the pillars of the legal bureaucracy that is inseparable from the demands of the litigating community to carry out their duties more professionally and in favor of the truth. As far as it is remembered, the attorney general's office in history has never felt so degenerated as it is today.

Originality/Value: Highlight and sharp criticism from the public, directed at him especially to the attorney general's office, in the near future does not seem to be receding, even though some improvements have been made.
Distance Learning in a Cyber Islamic University: Best Experience from Indonesia
Authors: Yusuf Ayus Ahmad , Toheri  , Nahwandi M. Syaoqi , Maryam Asmiyati Khusnul 
Published: May 2024

Backgroung: The quality of online learning is a demand for the State Islamic Institute of Syekh Nurjati Cirebon as a pilot project for a cyber-based Islamic university which since 2021 has had a distance learning program of Islamic Education Study Program. The Asian Association of Open Universities (AAOU) and Academic Partnership and The Asia-Pacific Economic Cooperation (APEC) organizations provide some criteria for the quality of online learning. Mixed research with sequential methods was carried out on the study program academic community using closed and open questionnaires online and through some focus group discussions. The results show that from 8 quality dimensions (leadership management, student and learner profile, student information and support, assessment and integrity, infrastructure, learning media and resources, learning design and development, curriculum design, and learning outcomes) the average score is in the range of 84-86. This shows that the implementation of the distance learning program is good, with the curriculum design dimension having the highest score while learning outcomes having the lowest score. This is supported by the results of open statements and some focus group discussion agendas that the curriculum is very in line with the development and profile of the study program. However, until now the study program has not had any graduates. Optimizing and updating the Learning Management System, standardizing assessments, and accuracy of feedback are the aspects that need to be improved by the distance learning program.

Objective: The aim of this research is to determine the level of service quality and student expectations regarding distance education carried out by the Syekh Nurjati State Islamic Institute, Cirebon, Indonesia.

Method: This research adopts mix methods approach with sequential explanatory design. The data obtained through online closed and open questionnaires as well as Focus Group Discussion (FGD) with managers.

Results and Discussion: The results show that from 8 quality dimensions (leadership management, student and learner profile, student information and support, assessment and integrity, infrastructure, learning media and resources, learning design and development, curriculum design, and learning outcomes) the average score is in the range of 84-86. The results obtained revealed that implementation of the distance learning program is good, with the curriculum design dimension having the highest score while learning outcomes having the lowest score. This is supported by the results of open statements and some focus group discussion agendas that the curriculum is very in line with the development and profile of the study program.

Research Implications: The implication of this research are as follows: Optimizing and updating the Learning Management System, standardizing assessments, and accuracy of feedback are the aspects that need to be improved by the distance learning program.
Water as A Transversal Axis of Learning in School Textbooks For Chilean Primary Education Students
Authors: Sepúlveda-Obreque Alejandro , Opazo-Salvatierra Margarita , Villalobos-Clavería Alejandro , Delgado-Delgado Hernán , Ulloa-Jaramillo Carlos 
Published: May 2024

Objective: The objective of this study is to investigate the presence of water as a transversal learning axis in the activities of Natural Science textbooks in Chilean Basic Education.

Theoretical Framework: The theoretical framework is associated with the 2030 Agenda and the Sustainable Development Goals, the Chilean science curricular bases, as well as the didactic management associated with school textbooks.

Method: The mixed method is followed, through content analysis, the elaboration of a priori categories, supported by quantitative elements to describe and interpret the data obtained from the analysis of school textbooks.

Results and Discussion: The results obtained revealed the presence of activities, still insufficient, that deal with the topic of water in the texts. The highest frequencies of educational activities are found in the fifth and sixth grades. The skills promoted are intellectual capacities (operations to acquire, recover, solve problems and retain different types of knowledge); on the other hand, the skills that demand a process of practice (mastery of the technique or skill), attitudes and habits, such as ways of acting and behaving, are the least promoted.

Research Implications: The implications of the study are referred to the methodology of science teaching in Basic Education and the respective teacher training.

Originality/value: The results of the study contribute to filling a gap in the literature related to the teaching of water proposed in school textbooks. With this, guidelines are provided to improve the activities suggested in the textbooks, promoting awareness of water, its reuse and conservation.