bluuebunny/crossref_metadata_2025_split huggingface dataset:
Merely possible explanation
Authors: GUIGON GHISLAIN 
Published: June 2010

AbstractGraham Oppy has argued that possible explanation entails explanation in order to object to Richard Gale and Alexander Pruss's new cosmological argument that it does not improve upon familiar cosmological arguments. Gale and Pruss, as well as Pruss individually, have granted Oppy's inference from possible explanation to explanation and argue that this inference provides a reason to believe that the strong principle of sufficient reason is true. In this article, I shall undermine Oppy's objection to the new cosmological argument by arguing that it is logically possible that some truths are merely possibly explained.
Continuous creation and secondary causation: the threat of occasionalism
Authors: MILLER TIMOTHY D. 
Published: June 2010

AbstractOne standard criticism of the doctrine of continuous creation is that it entails the occasionalist position that God alone is a true cause and that the events we commonly identify as causes are merely the occasions upon which God brings about effects. I begin by clearly stating Malebranche's argument from continuous creation to occasionalism. Next, I examine two strategies for resisting Malebranche's argument – strong and weak concurrentism – and argue that weak concurrentism is the more promising strategy. Finally, I argue that weak concurrentism requires a necessitarian approach to secondary causation.
Sceptical theism and divine lies
Authors: WIELENBERG ERIK J. 
Published: June 2010

AbstractIn this paper I develop a novel challenge for sceptical theists. I present a line of reasoning that appeals to sceptical theism to support scepticism about divine assertions. I claim that this reasoning is at least as plausible as one popular sceptical theistic strategy for responding to evidential arguments from evil. Thus, I seek to impale sceptical theists on the horns of a dilemma: concede that either (a) sceptical theism implies scepticism about divine assertions, or (b) the sceptical theistic strategy for responding to evidential arguments from evil fails. An implication of (a) is that sceptical theism is at odds with any religious tradition according to which there are certain claims that we can know to be true solely in virtue of the fact that God has told us that they are true. This result will render conceding (a) unattractive to many sceptical theists.
Characteristics of dissociable human learning systems
Authors: Shanks David R. , St. John Mark F. 
Published: June 2010

AbstractA number of ways of taxonomizing human learning have been proposed. We examine the evidence for one such proposal, namely, that there exist independent explicit and implicit learning systems. This combines two further distinctions, (1) between learning that takes place with versus without concurrent awareness, and (2) between learning that involves the encoding of instances (or fragments) versus the induction of abstract rules or hypotheses. Implicit learning is assumed to involve unconscious rule learning. We examine the evidence for implicit learning derived from subliminal learning, conditioning, artificial grammar learning, instrumental learning, and reaction times in sequence learning. We conclude that unconscious learning has not been satisfactorily established in any of these areas. The assumption that learning in some of these tasks (e.g., artificial grammar learning) is predominantly based on rule abstraction is questionable. When subjects cannot report the “implicitly learned” rules that govern stimulus selection, this is often because their knowledge consists of instances or fragments of the training stimuli rather than rules. In contrast to the distinction between conscious and unconscious learning, the distinction between instance and rule learning is a sound and meaningful way of taxonomizing human learning. We discuss various computational models of these two forms of learning.
Screening for Chagas' disease in HIV-positive immigrants from endemic areas
Authors: RODRÍGUEZ-GUARDADO A. , ALVAREZ V. ASENSI , RODRÍGUEZ PEREZ M. , ALVAREZ P. MEJUTO , FLORES-CHAVEZ M. , GONZÁLEZ P. ALONSO , SÁNCHEZ J. A. CARTÓN 
Published: June 2010

SUMMARYChagas' disease is an opportunistic infection in the setting of HIV/AIDS. The arrival of HIV-positive immigrants from endemic areas to non-endemic countries makes possible the detection of Chagas' disease in this group of patients. We describe the results of a screening programme conducted in the HIV-positive immigrant population arriving from endemic areas who attended the Tropical Medicine Unit of Hospital Universitario Central of Asturias during 2008. We determined anti-T. cruzi antibodies in all HIV patients arriving from endemic areas who were followed up. The ID-Chagas antibody test was used as a screening assay. The positive cases were confirmed with ELISA, IFAT and PCR. We analysed 19 HIV-positive immigrants, of which two (10·5%) had a positive antibody test for Chagas' disease confirmed. PCR was positive in both cases. There was no difference between the co-infected and the non-co-infected patients with respect to race, place of birth and residence, CD4+ cell count, and HIV viral load count. Direct microscopic examination of blood was negative in both positive cases. The positive patients were a man from Bolivia and woman from Paraguay. The overlap of HIV and T. cruzi infection occurs not only in endemic areas but also in non-endemic areas of North America and Europe where the diagnosis may be even more difficult due to low diagnostic suspicion. The implementation of screening programmes in this population group is needed for the early diagnostic of Chagas' disease.
Model predictions and evaluation of possible control strategies for the 2009 A/H1N1v influenza pandemic in Italy
Authors: AJELLI M. , MERLER S. , PUGLIESE A. , RIZZO C. 
Published: June 2010

SUMMARYWe describe the real-time modelling analysis conducted in Italy during the early phases of the 2009 A/H1N1v influenza pandemic in order to estimate the impact of the pandemic and of the related mitigation measures implemented. Results are presented along with a comparison with epidemiological surveillance data which subsequently became available. Simulated epidemics were fitted to the estimated number of influenza-like syndromes collected within the Italian sentinel surveillance systems and showed good agreement with the timing of the observed epidemic. On the basis of the model predictions, we estimated the underreporting factor of the influenza surveillance system to be in the range 3·3–3·7 depending on the scenario considered. Model prediction suggested that the epidemic would peak in early November. These predictions have proved to be a valuable support for public health policy-makers in planning interventions for mitigating the spread of the pandemic.
Molecular epidemiology of hepatitis E virus in humans, pigs and wild boars in Sweden
Authors: WIDÉN F. , SUNDQVIST L. , MATYI-TOTH A. , METREVELI G. , BELÁK S. , HALLGREN G. , NORDER H. 
Published: June 2010

SUMMARYHepatitis E infections in humans are usually acquired in endemic countries in Asia or Africa. In Sweden 17 cases infected in Europe, between 1993 and 2009, were identified. All had clinical hepatitis E with unknown source of infection. Hepatitis E virus (HEV) was identified in faecal samples from 63 piglets in 12 pig farms in Sweden. HEV was also identified in blood from 13 out of 159 investigated Swedish wild boars from nine counties. Partial HEV genomes from humans, pigs and wild boars were sequenced and compared by phylogeny. The results showed close relatedness between HEV strains from piglets from the same farm and from wild boars from the same county. HEV strains from humans showed relatedness with strains from pigs and wild boars from the same county. This study showed that HEV strains form geographical clusters in the phylogenetic tree. The methods used in this study may thus be used for tracing the origin of an infecting strain. Furthermore, this study indicated that there are endemic sources of human HEV infections in Sweden.
The Cognitive Atlas: Employing Interaction Design Processes to Facilitate Collaborative Ontology Creation
Authors: Miller Eric , Seppa Christian , Kittur Aniket , Sabb Fred , Poldrack Russell 
Published: June 2010

AbstractThe Cognitive Atlas is a collaborative knowledge-building project that aims to develop an ontology that characterizes the current conceptual framework among researchers in cognitive science and neuroscience. The project objectives from the beginning focused on usability, simplicity, and utility for end users. Support for Semantic Web technologies was also a priority in order to support interoperability with other neuroscience projects and knowledge bases. Current off-the-shelf semantic web or semantic wiki technologies, however, do not often lend themselves to simple user interaction designs for non-technical researchers and practitioners; the abstract nature and complexity of these systems acts as point of friction for user interaction, inhibiting usability and utility. Instead, we take an alternate interaction design approach driven by user centered design processes rather than a base set of semantic technologies. This paper reviews the initial two rounds of design and development of the Cognitive Atlas system, including interactive design decisions and their implementation as guided by current industry practices for the development of complex interactive systems.
Simulation modelling as a tool for examining the consequences of spatial structure and connectivity on local and regional population dynamics
Authors: Kerr Lisa A. , Cadrin Steven X. , Secor Dave H. 
Published: June 2010

Abstract
Kerr, L. A., Cadrin, S. X., and Secor, D. H. 2010. Simulation modelling as a tool for examining the consequences of spatial structure and connectivity on local and regional population dynamics. – ICES Journal of Marine Science, 67: 1631–1639. An understanding of the mechanisms underlying population persistence makes fisheries management more effective. A model framework is described, which can test hypotheses about spatial structure and connectivity within and between populations and their influence on the productivity (spawning-stock biomass, SSB), stability (variation in SSB), resilience (time to rebuild SSB after environmental disturbance), and sustainability (maximum sustainable fishing mortality and yield) of systems. The general model consists of linked age-structured submodels that incorporate the unique demographics and dynamics of population components, along with the degree and type of connectivity between them. The flexibility of this framework is illustrated with three case studies examining (i) spatial structure within a population of white perch, (ii) different types and degrees of connectivity between populations of Atlantic herring, and (iii) spatial heterogeneity and connectivity within a stock of Atlantic cod. System variance is reduced by abundant, stable population components, and the asynchronous responses of those components. Components with high productivity contributed disproportionately to the resilience of systems. Increased synchrony of component responses to environmental forcing decreased the stability of the overall system. Simulation modelling is a useful approach to evaluate the consequences of spatial structure and connectivity, and can be used to understand better the productivity and dynamics of local and regional populations.
Gene expression profiling and network analysis of peripheral blood monocytes in a chronic model of allergic asthma
Authors: Dorsam Glenn P. , Hoselton Scott A. , Sandy Ashley R. , Samarasinghe Amali E. , Vomhof‐DeKrey Emilie E. , Dorsam Sheri T. , Schuh Jane M. 
Published: June 2010

ABSTRACTThe Aspergillus fumigatus mouse model of asthma mimics the characteristics of human fungal asthma, including local and systemic inflammation. Monocyte/macrophage lineage cells direct innate immune responses and guide adaptive responses. To identify gene expression changes in peripheral blood monocytes in the context of fungal allergy, mice were exposed to systemic and intranasal inoculations of fungal antigen (sensitized), and naïve and sensitized animals were challenged intratracheally with live A. fumigatus conidia. Microarray analysis of blood monocytes from allergic versus non‐allergic mice showed ≥ twofold modulation of 45 genes. Ingenuity pathway analysis revealed a network of these genes involved in antigen presentation, inflammation, and immune cell trafficking. These data show that allergen sensitization and challenge affects gene expression in peripheral monocytes.
Interleukin‐8 induction due to diffusely adherent Escherichia coli possessing Afa/Dr genes depends on flagella and epithelial Toll‐like receptor 5
Authors: Arikawa Kentaro , Nishikawa Yoshikazu 
Published: June 2010

ABSTRACTDAEC is considered potentially diarrheagenic. For diffuse adhesion, the role of the Afa, which was originally identified as a uropathogenic factor, is now understood. However, the role of DAEC in diarrheal disease remains controversial because DAEC is often isolated not only from patients but also from healthy individuals. Previously, we suggested that Afa/Dr DAEC, which can induce high levels of IL‐8 secretion in cultures of human carcinoma epithelial cells (HEp‐2, Caco‐2), is enterovirulent. In the present study, we examined whether IL‐8 secretion induced by certain Afa/Dr DAEC strains was primarily due to flagella via TLR5. All IL‐8 high‐inducing strains were highly motile in swarming tests. Partially purified flagella induced IL‐8 in a dose‐dependent manner. However, IL‐8 induction was inhibited by small‐interfering RNA against TLR5 or by treating flagella with disialoganglioside‐GD1a, a TLR5 blocker. TLR5 is reportedly located on the basolateral side of intestinal epithelia; flagella should not have reached TLR5 from the apical side beyond tight junctions. Reduction in the number of intracellular organisms by wortmannin, a PI3K inhibitor, did not reduce IL‐8 secretion. Afa/Dr DAEC seemed to loosen the tight junctions because it quickly reduced transepithelial electrical resistance after infection. Decreased resistance led to increased IL‐8 production. In conclusion, diffuse adhesion itself is insufficient to induce high levels of IL‐8, and simultaneous stimulation by flagella via TLR5 is likely required for additional induction. Clinically, high motility may be a candidate criterion for predicting the ability of Afa/Dr DAEC strains to induce higher levels of IL‐8 secretion.
Resource discovery in ant communities: do food type and quantity matter?
Authors: PEARCE‐DUVET JESSICA M. C. , FEENER DONALD H. 
Published: June 2010

1. Omnivorous woodland ant species trade off between the ability to find and behaviourally control food resources. Dominant species can limit the ability of subordinates to harvest certain food items. However, subordinate species, by being faster discoverers, could gain access to such food items by arriving at them first.2. In this study, we tested the hypothesis that resource‐directed discovery occurs in ant communities and that good discoverers preferentially discover high value resources. We did this by measuring time to discovery and the number of discoveries of high and low levels of two resource types, crickets and honey, for species occurring in Texas and Arizona woodland ant communities.3. Ants discovered resources roughly 10 times faster in Texas than in Arizona. They discovered crickets more rapidly than honey in both communities, but there was no difference in the discovery of different resource levels. We also found that species were not biased in their discovery of different resource types or levels.4. These results provide indirect evidence that discovery is directed by resource stimuli but that such directedness does not impact interspecific exploitative competition.
Do changes in gastro‐intestinal blood flow explain high‐altitude anorexia?
Authors: Kalson Nicholas S. , Hext Faye , Davies Andrew J. , Chan Colin W. M. , Wright Alex D. , Imray Christopher H. E. ,   the Birmingham Medical Research Expeditionary Society
Published: June 2010

Eur J Clin Invest 2010; 40 (8): 735–741AbstractBackground  Gastrointestinal symptoms are common on acute exposure to high‐altitude (HA). Underlying mechanisms are not understood, but vascular shunting away from the gut could be responsible. Therefore, blood flow in the superior mesenteric artery (SMA) and hepatic portal vein (HPV) was examined at sea level (SL) and after ascent to 4392 m (HA).Materials and methods  Twelve subjects [eight male, mean age 40 (22–72) years] were studied following an overnight fast and a standard meal. Cross‐sectional vessel area and blood velocity were measured by ultrasound, systolic and diastolic flow calculated for the SMA (HR × vessel area × velocity, cm3 min−1) and mean flow for the HPV.Results  All subjects experienced reduced appetite at HA. Blood flow in the SMA and HPV increased following food at SL (mean SMA systolic flow 1024 vs. 3316 cm3 min−1, P < 0·001; HPV 505 vs. 1789, P < 0·001) and at HA (2020 vs. 3767, P < 0·001; HPV 708 vs. 1727, P < 0·001). Pre‐prandial flow in the SMA and HPV was significantly increased at HA compared with SL. The changes were due to increased vessel diameter and increased flow velocity. There was no difference in post‐prandial flow between SL and HA in the HPV, although the increase in post‐prandial flow was greater at SL than HA (254% increase vs. 144%).Conclusions  These results show that resting blood flow in the gastrointestinal tract is increased during exposure to high‐altitude hypoxia, and that the vascular response of increased blood flow following food ingestion is maintained. Therefore, reduced flow is unlikely to cause gastrointestinal symptoms and reduced appetite at HA.
Recruitment variation in a stream galaxiid fish: multiple influences on fry dynamics in a heterogeneous environment
Authors: JELLYMAN PHILLIP G. , MCINTOSH ANGUS R. 
Published: June 2010

Summary1. The relative importance of density‐dependent and density‐independent processes in explaining fluctuations in natural populations has been widely debated. In particular, the importance of larval supply and whether it may control the type of regulatory processes a population experiences has proved contentious.2. Using surveys and field experiments conducted in streams in Canterbury, New Zealand, we investigated how variation in the survival of non‐migratoryGalaxias vulgarisfry was affected by density‐dependent and density‐independent processes and how this variation influenced recruitment dynamics.3. Fry populations with high settlement densities experienced a 70–80% reduction in population size from density‐related mortality during the first fourteen days after peak settlement but thereafter the influence of density‐dependent processes on fry was weak. The impact of environmental conditions on fry populations was dependent on fry size and the magnitude of the perturbation, such that flooding effects on fry survival were most severe when fry were small.4. In streams not affected by flooding, the size and density of introduced trout (Salmo truttaandOncorhynchus mykiss) were the most significant factors determining the abundance of eventual recruits. A field experiment manipulating brown trout access to fry populations revealed that trout as small as 110 mm may be capable of greatly reducing and possibly preventing galaxiid recruitment.5. Overall, the results indicated density‐dependent population regulation was only possible at sites with high native fish densities because trout were likely to be suppressing the number of potential recruits at sites with low native fish numbers. Whilst density‐dependent processes had a strong effect on fry survival following the period of peak fry abundance, density‐independent processes associated with flow and predatory trout influences on fry survival largely determined recruitment variability among galaxiid populations. Focusing conservation efforts on improving habitat to increase fry retention and reducing the impacts of trout on galaxiids would ensure more native fish populations reached their potential abundance.
Processing the first birth: journeying into ‘motherland’
Authors: Dahlen Hannah G , Barclay Lesley M , Homer Caroline SE 
Published: June 2010

Aims and objectives.  To explore first‐time mothers’ experiences of birth at home and in hospital in Australia.Background.  The first birth has unique physical and psychological impacts on women. With the first birth, women become mothers.Design.  A grounded theory methodology was used. Data were generated from in‐depth interviews with women in their own homes.Methods.  Nineteen women were interviewed in Sydney, Australia. The experiences of seven women who gave birth for the first time in a public hospital and seven women who gave birth for the first time at home were contrasted with two mothers who gave birth for the first time in birth centres, one mother who gave birth for the first time in a private hospital and two women who had given birth more than once.Results.  Following the birth, women ‘processed the birth’ by ‘remembering’, ‘talking (storytelling)’ and ‘feeling’. This activity appeared to help most women resolve their feelings about the birth and understand what it actually means to be a new mother. ‘Personal and social integration’ occurred for most women as they entered ‘motherland’.Conclusion.  First‐time mothers appear to ‘process the birth’ to a greater extent than multiparous women because they are experiencing this for the first time. These women also have limited social networks in ‘motherland’, and these are facilitated through sharing the experiences of their labour or ‘processing the birth’.Relevance to clinical practice.  Identifying the novice status of first‐time mothers and understanding the way they process the birth can help health providers to be sensitive to the specific needs of primiparous women. In particular, their need to tell their birth stories following birth; understanding that these stories help women to process the birth and connect to other women.