bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tumour budding in invasive ductal breast carcinomas: correlation with clinicopathological prognostic parameters and hormone receptor status
Authors: Francis Sachin Sebastian , Sharma Swati 
Published: February 2025

IntroductionBreast cancer is a leading cause of morbidity and mortality among women. Advances in molecular biology have improved detection and treatment, but conventional histopathological factors remain crucial for prognosis. Tumour budding, defined as clusters of less than 5 tumour cells detached from the main tumour, has been linked to poor prognosis in several cancers. This study explores the association between intra-tumoral budding (ITB) and peripheral tumour budding (PTB) with known prognostic factors in Invasive Breast Carcinoma of no special type (IBC NST).Materials and methodsThis retrospective study analysed 70 cases of IBC NST diagnosed at Kasturba Medical College, Manipal, between January 2020 and December 2021. Tumour budding was classified as high-grade or low-grade based on density, which denotes the number of buds per x20 field. Clinicopathological data, including hormone receptor status, Ki-67 index, lymphovascular invasion (LVI), perineural invasion (PNI), and axillary lymph node involvement, were obtained. Statistical analyses were performed to identify a significant association between tumour budding and these factors. Univariate and multivariate logistic regression analyses were also done to demonstrate the significance of association.ResultsHigh-grade PTB showed significant associations with LVI (p = 0.046), PNI (p = 0.017), and axillary lymph node involvement (p = 0.021). In contrast, high-grade ITB was only significantly correlated with axillary lymph node involvement (p = 0.044). LVI (p-value = 0.240) and axillary lymph node involvement (p-value = 0.142) did not show any association with PTB on multivariate analysis and PNI (p-value = 0.074) near significant association with PTB). A significant inverse association was observed between PTB and Ki-67 (p = 0.012), which remained significant in univariate and multivariate analysis (p-value = 0.017). No significant associations were found between tumour budding and hormone receptor status or menopausal status.ConclusionPeripheral tumour budding (PTB) is significantly associated with several poor prognostic factors in IBC NST, while intra-tumoral budding (ITB) correlates primarily with axillary lymph node involvement. Tumor budding, particularly PTB, could serve as an important prognostic marker in breast cancer. Further research is needed to standardize tumour budding assessment in clinical practice.
Поэзия и правда: автобиографический элемент в рассказе Георгия Рыбинцева Поцелуй через вуаль (1922)
Authors: Burlachenko Ekaterina , Molodiakov Vassili 
Published: February 2025

Слабый интерес читателей и литературоведов к авторам второстепенным или провинциальным может восприниматься — ошибочно или справедливо — как их непричастность к наиболее активным или «передовым» тенденциям своего времени. Жизни и творчеству Георгия Рыбинцева (1885-1944) посвящено крайне мало публикаций, все они недавние. Ранее этот поэт привлекал внимание исследователей преимущественно в контексте изучения литературной жизни Москвы и Петербурга перед первой мировой войной. Рыбинцев писал и прозу; единственный найденный пока беллетристический опыт — рассказ Поцелуй через вуаль. Oпубликованный в 1922 году в константинопольском еженедельнике Наши дни, рассказ ценен содержащимся в нем несомненным автобиографическим элементом и ярким описанием Константинополя в самом начале двадцатых. Достоверно известные факты биографии Рыбинцева могут послужить ключом к будущим комментариям рассказа Поцелуй через вуаль и другим произведениям этого малоизвестного автора. Факсимиле оригинального издания рассказа Поцелуй через вуаль прилагается к статье.
Komunikasi Dan Media Sosial: Analisis Framing Toleransi Agama Dan Budaya Dalam Menanggapi Kedatangan Paus Fransiskus Ke Indonesia
Authors: Ramadoni Muhamad Afdoli , Kholifah Nur , Azhima Nur , Saputri Jingga , Hidayatullah Hidayatullah 
Published: February 2025

Media sosial telah menjadi tempat menyebarnya beberapa isu sosial, pola pikir penggunanya yang telah dipengaruhi oleh apa yang telah dilihatnya di media sosial menyebabkan timbulnya sikap tersebut. Maraknya paham fundamentalis agama di media sosial dan sedikitnya konten mengenai moderasi beragama di media sosial menyebabkan sikap ini terus-menerus menjamur di sekitar masyarakat yang kemudian nantinya akan memberikan dampak buruk bagi toleransi beragama. Hal ini tidak dapat dibiarkan begitu saja karena Indonesia memiliki berbagai keanekaragaman budaya dan agama yang seharusnya saling menjaga satu sama lain. Sikap toleransi dapat dihilangkan dengan secara terbuka menerima perbedaan satu sama lainnya karena antar umat beragama dan makhluk sosial pastinya masyarakat akan saling terhubung. Menumbuhkan sikap toleransi sudah seharusnya menjadi kewajiban bagi masyarakat. Dengan adanya toleransi maka perbedaan yang ada Indonesia dan isu-isu di dalamnya akan terselesaikan.
The James Webb Interferometer: Space-based Interferometric Detections of PDS 70 b and c at 4.8 μm
Authors: Blakely Dori , Johnstone Doug , Cugno Gabriele , Sivaramakrishnan Anand , Tuthill Peter , Dong Ruobing , Pope Benjamin J. S. , Albert Loïc , Charles Max , Cooper Rachel A. , Furio Matthew De , Desdoigts Louis , Doyon René , Francis Logan , Greenbaum Alexandra Z. , Lafreniére David , Lloyd James P. , Meyer Michael R. , Pueyo Laurent , Ray Shrishmoy , Sánchez-Bermúdez Joel , Soulain Anthony , Thatte Deepashri , Thompson William , Vandal Thomas 
Published: February 2025

Abstract
We observed the planet-hosting system PDS 70 with the James Webb Interferometer, JWST's aperture masking interferometric mode within NIRISS. Observing with the F480M filter centered at 4.8 μm, we simultaneously fit geometrical models to the outer disk and the two known planetary companions. We redetect the protoplanets PDS 70 b and c at a signal-to-noise ratio (SNR) of 14.7 and 7.0, respectively. Our photometry of both PDS 70 b and c provides tentative evidence of mid-IR circumplanetary disk emission through fitting spectral energy distribution models to these new measurements and those found in the literature. We also newly detect emission within the disk gap at an SNR of ~4, a position angle of

22

0

−
15

+
10

@, and an unconstrained separation within ~200 mas. Follow-up observations will be needed to determine the nature of this emission. We place a 5σ upper limit of 208 ± 10 μJy on the flux of the candidate PDS 70 d at 4.8 μm, which indicates that if the previously observed emission at shorter wavelengths is due to a planet, this putative planet has a different atmospheric composition than PDS 70 b or c. Finally, we place upper limits on emission from any additional planets in the disk gap. We find an azimuthally averaged 5σ contrast upper limit >7 mag at separations greater than 110 mas. These are the deepest limits to date within ~250 mas at 4.8 μm and the first space-based interferometric observations of this system.
Comprehensive Parameter Determination of Exoplanets through Asteroseismic Host Star Constraints
Authors: Lin Wen-Xu , Qian Sheng-Bang , Zhu Li-Ying , Liao Wen-Ping , Li Fu-Xing , Shi Xiang-Dong , Li Lin-Jia , Zhao Er-Gang 
Published: February 2025

Abstract
This study develops a robust framework for exoplanet characterization by leveraging asteroseismic constraints on host stars. Using precise photometric data from missions such as Kepler and TESS, we derive stellar parameters, including mass, radius, and age, with high accuracy through asteroseismic analysis. These stellar parameters are incorporated as priors in a Bayesian framework to refine planetary properties such as the mass, radius, and orbital parameters. By applying Markov Chain Monte Carlo methods, we extract posterior distributions of planetary parameters, achieving significant improvements in precision and reliability. This approach is particularly effective for systems with evolved host stars, where precise stellar properties are essential for resolving uncertainties in planetary characterization. The results demonstrate the importance of asteroseismology in bridging stellar astrophysics and exoplanet science, enabling detailed studies of planetary system architectures and their dependence on host star properties. Our methodology underscores the synergy between stellar and planetary studies, paving the way for future research on exoplanet populations. This work provides a foundation for utilizing data from upcoming missions like PLATO, ensuring continued advancements in the precision and scope of exoplanet characterization.
Hubble Space Telescope Observations within the Sphere of Influence of the Powerful Supermassive Black Hole in PKS 0745-191
Authors: Hlavacek-Larrondo Julie , Choi 최현 Hyunseop 섭 , Guo 明 Minghao 浩 , Richard-Laferrière Annabelle , Rhea Carter , Prunier Marine , Russell Helen , Fabian Andy , Walsh Jonelle L. , Gingras Marie-Joëlle , McNamara Brian , Allen Steve , Chené André-Nicolas , Edge Alastair , Gendron-Marsolais Marie-Lou , McDonald Michael , Natarajan Priyamvada , Sanders Jeremy , Steiner James F. , Vigneron Benjamin , von der Linden Anja 
Published: February 2025

Abstract
We present Space Telescope Imaging Spectrograph observations from the Hubble Space Telescope of the supermassive black hole (SMBH) at the center of PKS 0745-191, a brightest cluster galaxy (BCG) undergoing powerful radio-mode active galactic nucleus (AGN) feedback (P
cav ~ 5 × 1045 erg s−1). These high-resolution data offer the first spatially resolved map of gas dynamics within an SMBH's sphere of influence under such powerful feedback. Our results reveal the presence of highly chaotic, nondrotational ionized gas flows on subkiloparsec scales, in contrast to the more coherent flows observed on larger scales. While radio-mode feedback effectively thermalizes hot gas in galaxy clusters on kiloparsec scales, within the core, the hot gas flow may decouple, leading to a reduction in angular momentum and supplying ionized gas through cooling, which could enhance accretion onto the SMBH. This process could, in turn, lead to a self-regulating feedback loop. Compared to other BCGs with weaker radio-mode feedback, where rotation is more stable, intense feedback may lead to more chaotic flows, indicating a stronger coupling between jet activity and gas dynamics. Additionally, we observe a sharp increase in velocity dispersion near the nucleus, consistent with a very massive M
BH ~ 1.5 × 1010
M
⊙ SMBH. The density profile of the ionized gas is also notably flat, paralleling the profiles observed in X-ray gas around galaxies where the Bondi radius is resolved. These results provide valuable insights into the complex mechanisms driving galaxy evolution, highlighting the intricate relationship between SMBH fueling and AGN feedback within the host galaxy.
Detection of a Peculiar Noise Type in the TESS “Fast” Light Curves
Authors: Kálmán Szilárd , Csizmadia Szilárd , Pál András , Szabó Gyula M. 
Published: February 2025

Abstract
We present the detection of a peculiar high-frequency noise component in the 20 s cadence Simple Aperture Photometry light curve of Transiting Exoplanets Survey Satellite. This effect (labeled as blue noise) may be attributed to the pointing instability (also known as satellite jitter) of the satellite. We present a common technique used in the mitigation of the jitter, by decorrelating against the subpixel position of the photo-center of the point-spread function of the star. We also show that a simple linear or polynomial technique may not yield satisfactory corrections, as the behavior or attitude of the noise properties may change considerably throughout the light curve.
En quête de mémoire. Mémoires d’enquêtes
Authors: Soulagnat Jean 
Published: February 2025

« Acte hautement symbolique, la réception au sein du personnel actif ne pouvait que s’entourer d’un cérémonial véritablement initiatique. C’est pourquoi il convenait, avant toute intervention, de prêter solennellement serment en justice. [En raison de la chaleur] je me présentai en chemisette et surtout sans cravate. Le scandale fut immédiat… »Jean Soulagnat, lauréat du concours autobiographique « Pour la mémoire de la DGCCRF », entame son récit au lendemain de Mai 68. On y découvrira un aspect peu présent dans les témoignages des lauréats des concours précédents : le militantisme syndical. Jean Soulagnat y a consacré une partie importante de sa vie et en raconte les divers épisodes avec lucidité. À propos de son métier, il offre au lecteur des anecdotes illustratives des contrôles qu’il a eu à effectuer sur le terrain. Il raconte également l’avènement de l’informatique et l’accomplissement parfois douloureux de la fusion entre la direction générale de la Concurrence et de la Consommation et la direction de la Consommation et de la Répression des Fraudes.À travers le récit de sa carrière, il contribue à répondre aux questions que suscite dans le grand public le rôle d’une administration mal connue. Il l’avoue lui-même : « [Lorsqu’il m’arrivait] d’être interrogé sur la profession que j’exerçais, [je remarquais] combien il était difficile de m’expliquer sur ce sujet, de façon à la fois simple et précise, devant des gens qui ignoraient l’existence même de mon administration. » Gageons qu’avec En quête de mémoire, mémoires d’enquêtes c’est chose faite.
The linguistic foundations of the mediatization of communities in digital culture
Authors: Szécsi Gábor 
Published: February 2025

This article argues that the information age reveals a new, hitherto unknown dimension of the community-building role of linguistic communication. This new linguistic structure, based on the convergence of different ways of using language, creates conditions for the synthesis of different forms of communities. We are increasingly witnessing a specific semantic change accompanying semiotic globalization that affects the structure, grammar, and vocabulary of increasingly stratified and group languages. As this study tries to highlight, this process involves a convergence of language use patterns between different communities in the sense of the convergence of imagery as a feature of electronic communication. This imagery acts as a global requirement for written and spoken expressions in national languages, thus pushing the language-use patterns of each community towards a single imagery of meaning. The study aims to point out that the specific linguistic world of electronic communications is the basis for the synthesis of the social forms associated with these uses of language through the semantic, grammatical, and stylistic convergence of oral and written language. The frequent alternation or combined use of technologies that presuppose literacy and orality can lead to the emergence of physical-virtual hybrid communities–the network society–in the spirit of this global linguistic culture that is becoming visual. The emergence of these new physical-virtual hybrid communities presupposes the emergence of a language based on the interaction of new communication technologies, which will leave its mark on the development of all national languages and is no longer confined to the world of e-mail and SMS.
Prevalence of Malaria among Apparently Healthy Blood Donors at Tertiary Health-care Center in Northeastern Tribal Region of India
Authors: Kumari Sushma , Kumar Divakar , Kumar Abhay , Saroj Usha , Shrivastava Priyanka , Verma Saket , Kujur Manisha , Sahu Upendra P , Prasad Anupa 
Published: February 2025

Abstract

Background:
Transfusion Transmitted Malaria is a major concern among blood donors in endemic countries. The Drugs and Cosmetic Act 1940 in India mandated testing of all blood donations for Malaria. Regular screening of malaria prevents severe transfusion-transmitted malaria, and shows its prevalence and enables its control among the population.

Material and Methods:
This is a 09-year retrospective observational study from 1st August 2014 to 31st July 2023 among apparently healthy blood donors in Blood Centre of Rajendra Institute of Medical Sciences, Jharkhand, a tertiary health care centre in tribal population-dominant region of India. Every donor’s sample is subjected to a malaria antigen test both for Plasmodium falciparum and Plasmodium vivax by One step, rapid, immunochromatographic test. Positive result by rapid diagnostic Antigen card tests were also analysed by microscopy (peripheral blood smear).

Results:
In the present study, the total number of blood units collected was 246,147. On screening of the total blood donors, 62,225 (25.27%) were voluntary donors and 183,942 (74.72%) were replacement donors. There were 2,27,731 (92.51%) male donors and 18,416 (7.48%) female donors. Among all the donors, only 61 (0.024%) malaria-positive donors were seen, all male.

Conclusion:
Malaria transmission is strictly monitored and controlled by governments in endemic regions. In addition to the direct spread by mosquito bites, malaria can also be transmitted by transfusion as blood is transfused mainly as whole blood in developing countries. The transmission by transfusion of blood remains a challenge to blood centres because of carriers of malaria in the population in endemic regions like Jharkhand, India. This is first long retrospective observational study of prevalence of malaria among apparently healthy blood donors in a tertiary care centre in Northeastern tribal region of India. It gives a rough idea of the effectiveness of various malaria control programs in remote, malaria-endemic regions.
Our experience with modified mini laryngoscore and its correlation with laryngeal exposure during microlaryngoscopy
Authors: Gandhi Sachin , Vaishnav Darshil 
Published: February 2025

ABSTRACT

Background:
Microlaryngoscopy is a commonly used transoral approach for the diagnosis and surgery of many laryngeal disorders. Adequate exposure is very important for proper instrumentation. Many patient-related factors affect exposure. Many studies have been done in the past to objectively evaluate these factors and provide a score to predict difficult laryngeal exposure (DLE). This study is an attempt to simplify the scoring system along with making it more reliable and easy to use.

Objectives:
The objectives are as follows: to preoperatively evaluate the patient for DLE, to correlate a relatively easier and effective modified mini-laryngoscore (MML) with DLE, and to confirm the contribution of high-risk factors to DLE.

Materials and Methods:
The materials and methods are as follows: Subjects: the patients who met the inclusion criteria to undergo transoral microlaryngoscopy were included in the study. A detailed history of change in voice and clinical examination and flexible videolaryngoscopy was done to identify the pathology. Study design: this is a retrospective study. Study setting: In the preoperative room, an assessment for prediction of laryngeal exposure by measuring all the parameters of MML was done, and the score was calculated. Intraoperatively, laryngeal exposure classification was done. Then, we correlated MML findings and their parameters with the laryngeal exposure status to check the validity of MML.

Results:
In our study, out of a total of 125 patients, the final score was found to be associated with a sensitivity of 90.24% to predict a DLE with 73.80% specificity. The findings for the three new parameters that were added, such as body mass index (BMI), history of neck surgery, and history of radiotherapy, were found to be statistically significant. These three parameters constitute high-risk factors and patients having any of these, namely BMI > 30 kg/m2, history of neck surgery, and history of radiotherapy have a 95%–100% chance of having DLE. When the set of 19 patients belonging to the high-risk group was separated, the sensitivity of the MML score was 83.33%, and the specificity was 100%.

Conclusion:
MML is a quick, easy, and sensitive score to preoperatively predict laryngeal exposure intraoperatively and holds significance in making operative plans. The new parameters like BMI, history of radiotherapy to head and neck region, and history of open neck surgery affect the region from mentum to thyroid. These parameters had a significant role to play in predicting the intraoperative exposure of the larynx.
Lycium barbarum glycopeptide reduces brain damage following ischemic stroke by inhibiting ferroptosis and oxidation
Authors: Zhang Wei , Tang Moushen , Wang Yujie , Huang Yongxia , Yu Zhexiong , Zhu Lihui , Wang Jian , So Kwok-Fai , Ruan Yiwen 
Published: February 2025

Abstract
Recent studies have indicated that stroke can lead to neuronal iron overload and lipid peroxidation. Lycium barbarum glycopeptide, which has a low molecular weight and potent antioxidant properties, may mitigate ferroptosis in stroke. We hypothesized that Lycium barbarum glycopeptide can effectively mitigate iron overload within ischemic neurons due to its robust antioxidant properties. The aims of this study were to investigate the effects of Lycium barbarum glycopeptide on ferroptotic damage following brain ischemia and explore the underlying mechanisms. A rat model of middle cerebral artery occlusion was established using the intraluminal filament method, and the rats were treated with Lycium barbarum glycopeptide for 7 consecutive days, beginning 24 hours after ischemia. Liproxstatin-1, a ferroptosis inhibitor, and Erastin, a ferroptosis activator, were used as controls. We found that treatment with Lycium barbarum glycopeptide resulted in significant reductions in infarct volume (as detected by triphenyltetrazolium chloride staining staining and magnetic resonance imaging) and neuronal death (as measured by Nissl staining), as well as improvements in sensory and motor functions in rats subjected to middle cerebral artery occlusion. Furthermore, treatment with Lycium barbarum glycopeptide alleviated anxiety and depression-like behaviors and improved memory. Additionally, Lycium barbarum glycopeptide effectively reduced the iron ion content in the ischemic penumbra of the cortex. Moreover, treatment with Lycium barbarum glycopeptide downregulated the expression of ferroptotic and oxidant proteins such as transferrin receptor 1, divalent metal transporter 1, and Acyl-CoA synthetase long-chain family member 4 and upregulated the expression of anti-ferroptotic and antioxidant proteins such as ferroportin 1, solute carrier family 7 member 11, glutathione, and glutathione peroxidase 4. However, these beneficial effects were reversed when ferroptosis was induced with the activator Erastin. Therefore, the positive effects of Lycium barbarum glycopeptide in ischemic stroke are likely mediated through activation of the anti-ferroptotic pathway and the antioxidative System Xc-glutathione-glutathione peroxidase 4 pathway. Overall, our findings highlight the potential use of Lycium barbarum glycopeptide as a neuroprotective agent targeting both ferroptosis and oxidation to decrease ischemic brain damage.
Eco-social new-materialist reflections for the Anthropocene
Authors: Bennett Jane , Connolly William E , Kwek Dorothy , Grear Anna 
Published: February 2025

Towards the end of 2019 Jane Bennett and William E Connolly visited Cardiff University as keynote speakers for the speaker series, ‘Imagining the Eco-Social: New Materialist Reflections for the Anthropocene’. Organized by Anna Grear, the series sought to push the boundaries of the social into more complex material engagements and brought law and justice-based questions haunting the so-called Anthropocene into conversation with new materialist and posthuman thinking. The speaker series was hosted by the Centre of Law and Society and by what was then known as the Environmental Justice Research Unit (later renamed the Centre for Environmental Law and Policy).
The keynote events were co-organized by Anna Grear and Dot Kwek. Before these two full and intense days, Bennett and Connolly joined Grear and Kwek for an interview. (The interview was filled with laughter and has been lightly edited for clarity.)