bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mortality Associated with Caregiving, General Stress, and Caregiving‐Related Stress in Elderly Women: Results of Caregiver‐Study of Osteoporotic Fractures
Authors: Fredman Lisa , Cauley Jane A. , Hochberg Marc , Ensrud Kristine E. , Doros Gheorghe ,   for the Study of Osteoporotic Fractures
Published: March 2010

OBJECTIVES: To investigate the separate and combined effects of caregiver status and high stress on mortality risk over 8 years in elderly women.DESIGN: Prospective cohort study conducted in four U.S. communities followed from 1999/01 (baseline) to December 31, 2007.SETTING: Home‐based interviews.PARTICIPANTS: Three hundred seventy‐five caregiver and 694 noncaregiver participants from the Caregiver‐Study of Osteoporotic Fractures (Caregiver‐SOF) who participated in the baseline Caregiver‐SOF interview.MEASUREMENTS: Caregiver status was based on SOF respondents' self‐report of performing one or more instrumental or basic activities of daily living for a relative or friend with impairments. Two measures of stress were used: Perceived Stress Scale and stress related to caregiving tasks. All‐cause mortality was the outcome.RESULTS: Caregivers were more stressed than noncaregivers; 19.7% of caregivers and 27.4% of noncaregivers died. Mortality was lower in caregivers than noncaregivers (adjusted hazard ratio, (AHR)=0.74, 95% confidence interval (CI)=0.56–0.89). High‐stress respondents had greater mortality risk than low‐stress respondents over the first 3 years of follow‐up (AHR=1.81, 95% CI=1.16–2.82) but not in later years. Likewise, high‐stress caregivers and noncaregivers had higher mortality risk than low‐stress noncaregivers, although low‐stress caregivers had significantly lower mortality than did noncaregivers, whether perceived stress or caregiving‐related stress was measured (AHR=0.67 and 0.57). Similar results were observed in analyses comparing spouse caregivers with married noncaregivers.CONCLUSION: Short‐term effects of stress, not caregiving per se, may increase the risk of health decline in older caregivers.
Diffuse Leukoencephalopathy and Brain Edema: Unusual Presentations of CNS Relapse of Acute Myeloid Leukemia
Authors: Schumann Michael , Kiewe Philipp , Hartlieb Sissel , Neumann Martin , Schilling Andreas , Koch Hans‐Christian , Thiel Eckhard , Korfel Agnieszka 
Published: March 2010

ABSTRACT An isolated CNS relapse is rarely seen in acute myeloid leukemia. However, it has a potentially fatal clinical outcome. We herein present the case of a 39‐year‐old man, who presented to our emergency room with horizontal diplopic images, vertigo, bilateral deafness, and progressing somnolence. Cerebral imaging revealed cerebral and cerebellar edema and a diffuse leukoencephalopathy. With the one‐year‐old history of an initially successfully treated FAB‐M0 acute myeloid leukemia (AML) in mind, a lumbar puncture was carried out that showed a vast number of myeloid blasts in the morphologic analysis of the cerebrospinal fluid. In conjunction with normal findings in the peripheral blood‐count with differential and the bone marrow examination a diagnosis of an isolated CNS relapse of the AML was made. Cytarabine chemotherapy was initiated and the symptoms resolved rapidly. To our surprise, cerebral imaging in the course of the treatment not only showed a resolution of the brain edema but also of the leukoencephalopathy, pointing to a direct infiltration of brain parenchyma by leukemic blasts. The case highlights the relevance of the CNS as a pharmacologic “sanctuary” for tumor cells in patients that on prior treatments have not received intrathecal chemotherapy or chemotherapeutics that cross the blood‐brain barrier.
Multiple Cranial Nerve Enhancement: Uncommon Imaging Finding in Early Infantile Krabbe's Disease
Authors: Ganesan Karthik , Desai Shrinivas , Hegde Anaita 
Published: March 2010

ABSTRACT Multiple cranial nerve enhancement in early infantile Krabbe's disease is an uncommon imaging finding. We present an 8‐month‐old infant with early infantile Krabbe's disease with enhancement of multiple cranial nerves and optic nerve hypertrophy.
Neuroradiologic Evidence of Pre‐Synaptic and Post‐Synaptic Nigrostriatal Dopaminergic Dysfunction in Idiopathic Basal Ganglia Calcification: A Case Report
Authors: Saito Takahiro , Nakamura Mitsuru , Shimizu Teruhiko , Oda Keiichi , Ishiwata Kiichi , Ishii Kenji , Isse Kunihiro 
Published: March 2010

ABSTRACTIdiopathic basal ganglia calcification (IBGC) is a neuropathological condition known to manifest as motor disturbance, cognitive impairment, and psychiatric symptoms. The pathophysiology of the psychiatric symptoms of IBGC, however, remains controversial. A previous biochemical study suggested that dopaminergic impairment is involved in IBGC. We thus hypothesized that dopaminergic dysfunction might be related with the psychiatric manifestations of IBGC. We used positron emission tomography to measure glucose metabolism and dopaminergic function in the basal ganglia of an IBGC patient with psychiatric symptoms. The results showed that widespread hypometabolism was evident in the frontal, temporal, and parietal cortices while the decline in dopaminergic function was severe in the bilateral striatum. The functional decline of the dopamine system in the calcified area of the bilateral striatum and the disruption of cortico‐subcortical circuits may contribute to clinical manifestations of IBGC in our patient.
Thromboembolic Events Associated with Neuroform Stent™ in Endovascular Treatment of Intracranial Aneurysms
Authors: Yahia Abutaher M. , Latorre Julius , Gordon Vickie , Whapham John , Malek Ali , Fessler Richard D. 
Published: March 2010

ABSTRACTBACKGROUND The incidence of thromboembolic events associated with Neuroform stent™ (Boston Scientific Target, Fremont, CA) is known from previous studies but there are uncertainties of scale. PURPOSE To report our rate of ischemic events associated with Neuroform stent™. METHODS Consecutive patients treated with Neuroform stent™ for intracranial aneurysms were prospectively enrolled from January 2003 to August 2006. Thromboembolic events as well as clinical outcomes were measured. Mean follow‐up was 12 months. RESULTS Successful stent deployment was achieved in (65/67) 97% of patients without any ischemic event. However, postoperative thromboembolic events were observed in 3 patients despite being on clopidogrel and aspirin. These 3 patients demonstrated poor platelet inhibitions in platelet aggregation (aggregometry) studies, and were successfully treated with intravenous eptifibatide with good outcome. The majority of the patients had good outcomes [Glasgow Outcome Score (GOS) 5 or National Institute of Health Stroke Scale (NIHSS) 0 in (63/67) 94%, GOS 4 or NIHSS 2 in 1 patient, and GOS 3 or NIHSS 4 was observed in 3 cases]. CONCLUSION Our study reveals that the thromboembolic events associated with Neuroform stent™ may present in a delayed fashion. These events can be successfully treated with good outcome. Therefore, postoperative close follow‐up is strongly recommended for all Neuroform stent™‐treated patients.
Distribution of Foxp3‐, CD4‐ and CD8‐positive lymphocytic cells in benign and malignant prostate tissue
Authors: VALDMAN ALEXANDER , JARAJ SARA JONMARKER , COMPÉRAT EVA , CHARLOTTE FRÉDERIC , ROUPRET MORGAN , PISA PAVEL , EGEVAD LARS 
Published: March 2010

Valdman A, Jaraj SJ, Compérat E, Charlotte F, Roupret M, Pisa P, Egevad L. Distribution of Foxp3‐, CD4‐ and CD8‐positive lymphocytic cells in benign and malignant prostate tissue. APMIS 2010; 118: 360–5.Foxp3 is a transcription factor that inhibits antitumor immune response and is expressed in regulatory T cells (Tregs). High levels of Tregs have been reported in several human cancers. This study investigates the distribution of cells positive for Foxp3, CD4 and CD8 in benign prostatic tissues and prostatic carcinoma. Tissue microarrays were constructed from radical prostatectomy specimens of 36 patients. From each patient, six cores were taken: two cores from cancer, one from benign tissue of each of the peripheral (PZ), transition (TZ) and central zones (CZ) and one from atrophy. Foxp3‐, CD4‐ and CD8‐positive cells were more common in cancer than in non‐atrophic benign tissue (p < 0.01) and more common in atrophy than in non‐atrophic PZ, but did not differ significantly between cancer and atrophy. Cells positive for Foxp3 and CD4 were less prevalent in CZ than in PZ and TZ. Tregs infiltrate more in prostate cancer (PC) than in benign tissue. Their presence in atrophy may have relevance for the hypothesis on atrophy as a potential precursor lesion of PC. CZ has the lowest Treg levels, and a possible role for the low rate of cancer in this zone remains to be investigated.
Pulmonary myoepithelial carcinoma resembling matrix‐producing carcinoma of the breast: case report and review of the literature
Authors: TANAHASHI JIN , KASHIMA KENJI , DAA TSUTOMU , YADA NAOMI , TANAKA KO‐ICHI , KAWANO YOZOH , YOKOYAMA SHIGEO 
Published: March 2010

Tanahashi J, Kashima K, Daa T, Yada N, Tanaka K‐I, Kawano Y, Yokoyama S. Pulmonary myoepithelial carcinoma resembling matrix‐producing carcinoma of the breast: case report and review of the literature. APMIS 2010; 118: 401–6.We report a case of pulmonary myoepithelial carcinoma with extensive myxohyaline stroma, resembling matrix‐producing carcinoma of the breast. A 76‐year‐old Japanese man presented with a nodular lesion in the left lung (S8), and underwent partial resection of the left lower lobe. Microscopically, the resected tumor was relatively well circumscribed with central hypocellular myxohyaline and peripheral hypercellular area. In the central area, eosinophilic and clear polygonal cells proliferated in a cord‐like or reticulated pattern with extensive myxohyaline stroma, while the peripheral area was composed of solid lobules of different shapes and sizes with occasional comedonecrosis. The tumor cells were markedly atypical with frequent mitotic figures. Vascular and lymphatic invasion was evident with regional lymph node metastasis. No squamous or glandular differentiation was evident in the tumor. Immunohistochemical staining implied myoepithelial differentiation. The patient developed multiple brain metastases, and died of the disease 11 months after the surgery. In this report, we discuss the histopathologic uniqueness of the present case together with a review of the literature.
Undifferentiated carcinoma of the renal pelvis with osteoclast‐like giant cells: a report of two cases
Authors: MCCASH SAMUEL I. , UNGER PAMELA , DILLON ROBERT , XIAO GUANG‐QIAN 
Published: March 2010

McCash SI, Unger P, Dillon R, Xiao G‐Q. Undifferentiated carcinoma of the renal pelvis with osteoclast‐like giant cells: a report of two cases. APMIS 2010; 118: 407–12.Undifferentiated carcinoma with osteoclast‐like giant cells arising in the urothelium of the bladder or upper urinary tract is an extremely rare entity. The majority of cases found in the renal pelvis and bladder are associated with either an in situ urothelial malignancy or a conventional high‐grade urothelial carcinoma. These malignancies tend to behave poorly with a grim prognosis and course. We report two additional cases of undifferentiated carcinoma with osteoclast‐like giant cells of the renal pelvis in two patients disease free 42 and 18 months after surgical treatment, respectively.
Accuracy of three‐dimensional imaging in assessing maxillary molar furcation involvement
Authors: Walter Clemens , Weiger Roland , Zitzmann Nicola U. 
Published: March 2010

Walter C, Weiger R, Zitzmann NU. Accuracy of three‐dimensional imaging in assessing maxillary molar furcation involvement. J Clin Periodontol 2010; 37: 436–441. doi: 10.1111/j.1600‐051X.2010.01556.x.AbstractAim: To assess the accuracy of cone beam computed tomography (CBCT) in detecting furcation involvement (FI) in maxillary molars.Material and Methods: Fourteen patients with generalized advanced chronic periodontitis were consecutively recruited and treated non‐surgically. In maxillary molars considered for furcation surgery due to increased FI and/or increased probing pocket depths during re‐evaluation, CBCT was performed and the degree of FI was evaluated from the CBCT images. Furcation surgery was performed in 25 maxillary molars. Intra‐surgical FI assessments were compared with data derived from CBCT images.Results: Overall, 84% of the CBCT data were confirmed by the intra‐surgical findings (weighted κ=0.926, 95% confidence interval: 0.681–1.0). While 14.7% (11 sites) were underestimated (CBCT less than intra‐surgical value), in only 1.3% (one site) did the CBCT data lead to an overestimation compared with the intra‐surgical analysis. The agreement between both assessments was the highest in distopalatal furcation entrances, followed by buccal and mesiopalatal.Conclusions: CBCT images demonstrate a high accuracy in assessing the loss of periodontal tissue and classifying the degree of FI in maxillary molars.
Granulomas in acquired immunodeficiency syndrome‐associated cutaneous Kaposi sarcoma: evidence for a role for Mycobacterium tuberculosis
Authors: Ramdial Pratistadevi K. , Sing Yetish , Subrayan Sumeshini , Calonje Eduardo , Aboobaker Jamila , Sydney Clive , Sookdeo Dinesh , Ramburan Amsha , Madiba Thandinkosi E. 
Published: March 2010

Background: Co‐lesional acquired immunodeficiency syndrome‐associated cutaneous Kaposi sarcoma (AIDS‐KS) and Mycobacterium tuberculosis‐associated granulomatous inflammation are undocumented. Method: Retrospective appraisal of skin biopsies with co‐lesional AIDS‐KS and microscopic tuberculosis (TB). Results: Sixteen biopsies from nine males and seven females form the study cohort. Histological assessment confirmed nodular and plaque KS in 12 and 4 cases each, respectively. Necrotizing, non‐necrotizing and a combination of necrotizing and non‐necrotizing granulomatous inflammation were present in nine, two and five biopsies each, respectively. The identification of acid fast bacilli on Ziehl‐Neelsen staining and M. tuberculosis on polymerase chain reaction confirmed co‐lesional TB in 15/16 biopsies. Co‐lesional AIDS‐KS and lichen scrofulosorum, hitherto undocumented, were confirmed in one biopsy. The histopathological findings served as a marker of human immunodeficiency virus (HIV) infection, visceral TB, therapeutic noncompliance and multidrug resistant pulmonary TB in nine, eight, five and one patient, respectively. M. tuberculosis was cultured from sputum or nodal tissue of all patients. Conclusion: Granulomatous inflammation in KS requires optimal histopathological and molecular investigation to confirm an M. tuberculosis origin. The cutaneous co‐lesional occurrence of AIDS‐KS and microscopic TB may serve as the sentinel clue to HIV infection, systemic TB, therapeutic noncompliance or multidrug resistant TB.Ramdial PK, Sing Y, Subrayan S, Calonje E, Aboobaker J, Sydney C, Sookdeo D, Ramburan A, Madiba TE. Granulomas in acquired immunodeficiency syndrome‐associated cutaneous Kaposi sarcoma: evidence for a role for Mycobacterium tuberculosis.
Frequency of congenital dyserythropoietic anemias in Europe
Authors: Heimpel Hermann , Matuschek Andreas , Ahmed Momin , Bader‐Meunier Brigitte , Colita Adriana , Delaunay Jean , Garcon Loic , Gilsanz Florinda , Goede Jeroen , Högel Josef , Kohne Elisabeth , Leichtle Rosi , Munoz Juan , Perrotta Silverio , Piscopo Carlo , Renella Raffaele , Schwarz Klaus , Smolenska‐Sym Gabriela , Wickramasinghe Sunitha , Zanella Alberto , Iolascon Achille 
Published: March 2010

AbstractCongenital dyserythropoietic anemias (CDAs) are rare hereditary disorders characterized by ineffective erythropoiesis and striking abnormalities of erythroblast morphology. The mutated genes are known for the most frequent types, CDA I and II, but data about their frequency do not exist. The objective of this retrospective study was to estimate the frequency of CDA I and II, based on all cases reported in the last 42 yr in publications and identified registries or surveys. Reports were collected of 124 and 377 confirmed cases of CDA I and CDA II cases, respectively. The cumulated incidence of both types combined varied widely between European regions, with minimal values of 0.08 cases/million in Scandinavia and 2.60 cases/million in Italy. CDA II is more frequent than CDA I, with an overall ratio of approximately 3.2, but the ratio also varied between different regions. The most likely explanations for the differences are both differences in the availability of advanced diagnostic procedures and different levels of the awareness for the diagnosis of the CDAs. The estimations reported here are most probably below the true incidence rates, because of failure to make the correct diagnosis and to underreporting. Limited data do not suggest differing levels of risk in identified ethnic groups.
Human melanocytes can be isolated, propagated and expanded from plucked anagen hair follicles
Authors: Dieckmann Christina , Milkova Linda , Hunziker Thomas , Emmendörffer Andreas , Simon Jan C. 
Published: March 2010

Please cite this paper as: Human melanocytes can be isolated, propagated and expanded from plucked anagen hair follicles. Experimental Dermatology 2010; 19: 543–545.Abstract:  Herein, we report a technically simple method for isolation and culture of human follicular melanocytes based on explant cultures of epilated hair follicles. This technique does not require any surgical intervention and allows the isolation and cultivation of follicular melanocytes from a comparatively small amount of raw material. Generally, 30–60 human anagen hair follicles have been plucked from the scalp of healthy donors and cultivated under low oxygen pressure (5%). After a short period of time cells of various types were growing out from the outer root sheath (ORS) of the hair follicles. Under the selected culture conditions, most of the cells other than melanocytes have been eliminated and a nearly 100% pure population of melanocytes has been achieved, as confirmed by immunohistochemical analyses for melanocyte‐specific markers, for example, Tyrosinase‐1, S‐100 and premelanosomal antigens. These melanocytes derived from the ORS were proliferating for up to 2 months.
Assessing Women’s Sexual Arousal in the Context of Sexual Assault History and Acute Alcohol Intoxication
Authors: Gilmore Amanda K. , Schacht Rebecca L. , George William H. , Otto Jacqueline M. , Davis Kelly Cue , Heiman Julia R. , Norris Jeanette , Kajumulo Kelly F. 
Published: March 2010

ABSTRACTIntroductionFew studies have examined differences in women’s sexual arousal based on sexual assault history (SAH) or in-the-moment alcohol intoxication. Only one has examined combined effects. Findings regarding the relationship between SAH and arousal are contradictory.AimWe aimed to determine the relationship between SAH, alcohol intoxication, and sexual arousal.MethodsWomen were randomly assigned to an alcohol (target blood alcohol level=0.10%) or control condition and categorized as having an SAH or not. After beverage administration, all women watched erotic films while genital arousal (vaginal pulse amplitude; VPA) was measured. Afterward, self-reported sexual arousal was measured.Main Outcome MeasuresGenital response was measured by VPA using vaginal photoplethysmography while watching erotic films. Self-reported sexual arousal was assessed after watching erotic films.ResultsWomen with an SAH had smaller increases in genital arousal in response to the films than women without an SAH. Intoxicated women had smaller increases in genital arousal than sober women. However, no differences for SAH or intoxication were found in self-reported arousal.ConclusionSAH and alcohol intoxication are associated with smaller increases in genital arousal compared to women without an SAH and sober women, suggesting that these co-occurring factors impact sexual arousal.
Repressive Coping Style and Its Relation to Psychosocial Distress in Males With Erectile Dysfunction
Authors: Wiltink Jörg , Subic-Wrana Claudia , Tuin Inka , Weidner Wolfgang , Beutel Manfred E. 
Published: March 2010

ABSTRACT

Introduction
There is evidence that repressive coping adversely affects medical conditions such as coronary heart disease, hypertension, and bronchial asthma. Erectile dysfunction (ED) is known to have a severe and lasting negative impact on health, quality of life, and partnership. Although ED may be eminently threatening for the self-image of affected men, a repressive coping style and its consequences for their mental health and partnership has not yet been investigated.

Aim
Based on the presumption that the male self-image is threatened by ED, we expected men with repressive coping strategies—although reporting the same degree of impairments regarding their sexual function—to describe themselves as more satisfied with: (i) their sexual relationship, to report (ii) a better quality of their partnership; and (iii) less distress (depression and physical complaints) as compared with those who do not use such strategies.

Methods
Fifty-nine patients with ED from the outpatient unit of the Clinic of Urology, Pediatric Urology and Andrology of the University of Giessen were examined using standardized German versions of international questionnaires. Coping style was determined using a combination of the State Trait Anxiety Inventory (STAI) and the Marlowe Crown Social Desirability Scale (SDS-CM) measuring defensiveness.

Main Outcome Measures
Questionnaires measuring anxiety (STAI), depression (Center for Epidemiological Studies Depression Scale), social desirability (SDS-CM), quality of partnership (Partnership Questionnaire), and physical complaints (Complaint List) were administered.

Results
Repressors did not differ from nonrepressors with regard to their self-reported sexual function (International Index of Erectile Function). However, they described themselves as less distressed (depression, physical complaints) and rated the quality of their partnership as higher.

Conclusion
Repressors tend to report their complaints in a manner that protects their self-worth. Clinicians therefore might have difficulties deciding whether and which treatment is necessary. Additional clinical information (e.g., interview together with the female partner) or questionnaires might prove useful sources of information on patients’ coping style.
Successful Removal of a 3.6-cm Long Metal Band Used as a Penile Constriction Ring
Authors: Horstmann Marcus , Mattsson Björn , Padevit Christian , Gloyer Marcel , Hotz Thomas , John Hubert 
Published: March 2010

ABSTRACT

Introduction
Penile constriction rings are either used for autoerotic stimulus or to increase sexual performance. Potentially, they can become irremovable and cause urologic emergencies.

Aim
We describe the successful removal of a 3.6-cm long piece of heavy metal tubing used as a penile constriction ring.

Methods
An angel grinder was used to open the metal tubing on both lateral sides. During the cutting procedure, the soft tissue parts were protected by two metal spatulas. Wet towels and cool running water prevented thermal injury.

Results
After removal of the band, no iatrogenic injury was visible and the further recovery of the patient remained uneventful. Postoperatively, one of the surgeons suffered from conjunctivitis of the left eye possibly due to metal sparks.

Conclusion
Depending on the constricting object, heavy-duty technical equipment might become necessary for their removal. In such cases, special care should be taken to avoid injury to the patient and the medical crew.