bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep postnatal phenotyping of a new mouse model of nonketotic hyperglycinemia
Authors: Swanson Michael A. , Jiang Hua , Busquet Nicolas , Carlsen Jessica , Brindley Connie , Benke Tim A. , Van Hove Roxanne A. , Friederich Marisa W. , MacLean Kenneth N. , Mesches Michael H. , Van Hove Johan L. K. 
Published: June 2024

AbstractNonketotic hyperglycinemia due to deficient glycine cleavage enzyme activity causes a severe neonatal epileptic encephalopathy. Current therapies based on mitigating glycine excess have only limited impact. An animal model with postnatal phenotyping is needed to explore new therapeutic approaches. We developed a Gldc p.Ala394Val mutant model and bred it to congenic status in two colonies on C57Bl/6J (B6) and J129X1/SvJ (J129) backgrounds. Mutant mice had reduced P‐protein and enzyme activity indicating a hypomorphic mutant. Glycine levels were increased in blood and brain regions, exacerbated by dietary glycine, with higher levels in female than male J129 mice. Birth defects were more prevalent in mutant B6 than J129 mice, and hydrocephalus was more frequent in B6 (40%) compared to J129 (none). The hydrocephalus rate was increased by postnatal glycine challenge in B6 mice, more so when delivered from the first neonatal week than from the fourth. Mutant mice had reduced weight gain following weaning until the eighth postnatal week, which was exacerbated by glycine loading. The electrographic spike rate was increased in mutant mice following glycine loading, but no seizures were observed. The alpha/delta band intensity ratio was decreased in the left cortex in female J129 mice, which were less active in an open field test and explored less in a Y‐maze, suggesting an encephalopathic effect. Mutant mice showed no evidence of memory dysfunction. This partial recapitulation of human symptoms and biochemistry will facilitate the evaluation of new therapeutic approaches with an early postnatal time window likely most effective.
Development and trend of dairy cleaning agents
Authors: Su Hong , Chai Jing , Li Xiang , Kong Yangzhi , Zhang Yanling , Kang Jing , Dong Alideertu 
Published: June 2024

AbstractThe quality and safety of dairy products are highly valued by consumers and dairy manufacturers, which is mainly ensured by thorough cleaning of dairy production equipment. Milk fouling can cause pipes to clog and reduce transmission. Incomplete cleaning can cause microbial breeding, which will affect the quality and safety of dairy products. To achieve efficient and rapid cleaning of dairy processing equipment, cleaning agents have always been a necessary choice for dairy and food enterprises. This paper describes the production mechanism of milk fouling, the cleaning mechanism by cleaning agents, and the cleaning process. Development of cleaning agents are introduced in detail, include compound alkaline/acid/neutral cleaning agents, enzyme cleaning agents and cleaning additives. The factors affecting cleaning efficiency are also viewed, which include type and dosage of cleaning agents, cleaning process (cleaning time, cleaning liquid temperature, cleaning fluid flow rate), and other influencing factors (cleaning fluid pressure, Reynolds number and shear stress, surface types). Four aspects are reviewed in this manuscript, include cleaning objects (milk fouling), cleaning substances (cleaning agents), how to clean (cleaning mechanism) and how to clean efficiently (cleaning influencing factors), which provides a valuable reference for the improvement of the dairy cleaning process.
Nonanatomic femoral tunnel placement increases the risk of subsequent meniscal surgery after ACLR: Part II—Patients without recurrent ACL injury
Authors: Inoue Jumpei , Giusto Joseph D. , Dadoo Sahil , Nukuto Koji , Lesniak Bryson P. , Musahl Volker , Hughes Jonathan D. 
Published: June 2024

AbstractPurposeThe purpose of this study was to identify risk factors for subsequent meniscal surgery following anterior cruciate ligament (ACL) reconstruction (ACLR) in patients without recurrent ACL injury.MethodsPatients aged ≥14 years who underwent primary ACLR with minimum 1‐year follow‐up and without recurrent ACL injury were retrospectively reviewed. Patient demographics and surgical data at the time of ACLR were collected. Postoperative radiographs were used to measure femoral and tibial tunnel position, and posterior tibial slope. Univariate and multivariate analyses were performed to identify risk factors for subsequent meniscal surgery.ResultsOf 629 ACLRs that fulfilled the inclusion criteria, subsequent meniscal surgery was performed in 65 [10.3%] patients. Multivariate analysis revealed that medial meniscal repair at the time of ACLR, younger age, anterior femoral tunnel position and distal femoral tunnel position were significantly associated with subsequent meniscal surgery (p < 0.001, p = 0.016, p = 0.015, p = 0.035, respectively). The frequency of femoral tunnel placement >10% outside of the literature‐established anatomic position was significantly higher in those who underwent subsequent meniscal surgery compared to those who did not (38.3% vs. 20.3%, p = 0.006). Posterior tibial slope and ACL graft type were not significantly associated with subsequent meniscal surgery.ConclusionMedial meniscal repair at the time of ACLR, younger age and nonanatomic femoral tunnel placement were risk factors for subsequent meniscal surgery in patients without recurrent ACL injury. Femoral tunnel placement <10% outside of the native anatomic position is important to reduce the risk of subsequent meniscal surgery.Level of EvidenceLevel IV.
Clinical Effect Analysis of Fire‐needle Acupuncture at Neiyingxiang Treating Persistent Allergic Rhinitis
Authors: Ai Jianwei , Guo Suying , Wang Yaqin , Kang Yuezhi , Wang Man , Zhao Jingyi , Huang Shaoting , Wang Junge 
Published: June 2024

ObjectivesWe conducted the first trial to evaluate the effect that fire‐needle acupuncture at Neiyingxiang (ExHN 9) in patients with moderate to severe persistent AR.MethodsThis was a randomized, single‐center, sham, and placebo‐controlled rial. Patients were kept blinded to their group assignment. All participants were equally assigned to the fire‐needle acupuncture (FA) treatment group, sham fire‐needle acupuncture (SFA) group, or loratadine group. The trial was designed with an acupuncture intervention once a week for 4 weeks and follow‐up 4 weeks. The Total Nasal Symptom Scores (TNSS), Total Non‐Nasal Symptom Scores (TNNSS), Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ), Allergic Rhinitis Control Test (ARCT), and total nasal resistance of 150 Pa were evaluated as outcome measures.ResultsA total of 180 participants were enrolled, and 175 participants completed the trials. At 2 and 4 weeks, the TNSS, TNNSS, and RQLQ scores of the FA and loratadine groups were significantly lower than those of the SFA group. At 8 weeks, the scores of loratadine group increased compared with the FA group (Cohen's d >0.80, p < 0.01). The ACRT score of the FA treatment group rose gradually. After treatment, the total nasal resistance of the FA group was significantly decreased and was lower than that of the other two groups (Cohen's d >0.80, p < 0.01).ConclusionFire‐needle acupuncture at Neiyingxiang (ExHN 9) is effective for improving nasal allergy symptoms and quality of life in patients with moderate and severe persistent AR, and the duration of its effects is long.Level of Evidence2 Laryngoscope, 134:4471–4479, 2024
Preparation of Autoclavable and Injectable Silk Fibroin Cryogels for Tissue Engineering Applications
Authors: Han Hongjuan , Li Haiyan , Wang Lu , Zhu Yong , Guan Haoqing , Yao Jingzhi , Xiao Wenqian , Li Bo , Liao Xiaoling 
Published: June 2024

AbstractA cryogel is a supermacroporous gel network that is generated at subzero temperatures by polymerizing monomers or gelating polymeric precursors. Since cryogels possess inherent characteristics such as interconnected macroporous structures, excellent mechanical properties, and high resistance to autoclave sterilization, they are highly desirable for tissue engineering and regenerative medicine. Silk fibroin, a natural protein obtained from Bombyx mori silkworms, is an excellent raw material for cryogel preparation. The aim of this study is to establish a controlled method for preparing silk fibroin cryogels with suitable properties for application as tissue engineering scaffolds. Using a dual crosslinking strategy consisting of low‐temperature radical polymerization coupled with methanol‐induced conformational transformation, porous cryogels are prepared. The cryogels display many unique characteristics, such as an interconnected macroporous structure, a high water absorption capacity, water‐triggered shape memory, syringe injectability, and strong resilience to autoclave sterilization. Furthermore, the cryogels demonstrate excellent biocompatibility and cell affinity, facilitating cell adhesion, migration, and proliferation. The interconnected supermacroporous architecture resembling the native extracellular matrix, together with their unique physical properties and autoclaving stability, suggests that cryogels are promising candidate scaffolds for tissue engineering and cell therapy.
Fabrication of Triblock Elastomer Foams and Gelation Studies for Oil Spill Remediation
Authors: Lee Hyejin , Trinh Binh M. , Mekonnen Tizazu H. 
Published: June 2024

AbstractPolymeric foamed materials are among the most widely utilized technologies for oil spill accidents and releases of oil‐contaminated wastewater oil due to their porosity to absorb and separate oil/water effectively. However, a major limitation of traditional polymeric foams is their reliance on an ad/absorption mechanism as the sole method of oil capture, leading to potential oil leakage once their saturation point is exceeded. Tri‐block polymer styrene‐ethylene‐butylene‐styrene (SEBS) is a fascinating absorbent material that can bypass this limitation by both capturing oil and providing a sealing mechanism via gelation to prevent oil leakage due to its unique chemical structure. SEBS foams are produced via simultaneous crosslinking and foaming that results in an impressive expansion ratio of up to 15.2 with over 93% porosity. Most importantly, the SEBS foams show great potential as oil absorbents in spill remediation, demonstrating rapid and efficient oil absorption coupled with superhydrophobic properties. Moreover, the unique interaction between the oil and SEBS enables the formation of a physical gel, acting as an effective barrier against oil leakage. These findings indicate the potential for commercializing SEBS foam as a viable option for geotextiles to mitigate oil spill concerns from infrastructures.
PROteolysis‐Targeting Chimeras (PROTACs) in leukemia: overview and future perspectives
Authors: Vicente André T. S. , Salvador Jorge A. R. 
Published: June 2024

AbstractLeukemia is a heterogeneous group of life‐threatening malignant disorders of the hematopoietic system. Immunotherapy, radiotherapy, stem cell transplantation, targeted therapy, and chemotherapy are among the approved leukemia treatments. Unfortunately, therapeutic resistance, side effects, relapses, and long‐term sequelae occur in a significant proportion of patients and severely compromise the treatment efficacy. The development of novel approaches to improve outcomes is therefore an unmet need. Recently, novel leukemia drug discovery strategies, including targeted protein degradation, have shown potential to advance the field of personalized medicine for leukemia patients. Specifically, PROteolysis‐TArgeting Chimeras (PROTACs) are revolutionary compounds that allow the selective degradation of a protein by the ubiquitin–proteasome system. Developed against a wide range of cancer targets, they show promising potential in overcoming many of the drawbacks associated with conventional therapies. Following the exponential growth of antileukemic PROTACs, this article reviews PROTAC‐mediated degradation of leukemia‐associated targets. Chemical structures, in vitro and in vivo activities, pharmacokinetics, pharmacodynamics, and clinical trials of PROTACs are critically discussed. Furthermore, advantages, challenges, and future perspectives of PROTACs in leukemia are covered, in order to understand the potential that these novel compounds may have as future drugs for leukemia treatment.
Torque fault compensation in electric vehicle switched reluctance motor drives: A jellyfish search optimization method
Authors: Anita S. , Sukhi Y. , Jeyashree Y. , Manoj Kumar N. 
Published: June 2024

AbstractIn this paper, an enhanced indirect instantaneous‐torque‐control is proposed based on the torque sharing function approach of switched reluctance motor drives for electric vehicles by employing the jelly fish search. The major goal is to attain vehicle desires that include minimal torque ripple, maximum torque per ampere (MTPA), and huge performance and extend speed limit. First, a simplest analytic design is developed a determine more proficient turn‐on angle for the torque product. Second, an altered torque sharing function (TSF) is used for compensating the faults of torque tracking. The proposed technique is calculated to represent an accurate switched reluctance motor and its magnetized features. They have worked to create the machine model and execute the necessary transmits. The torque fault is evaluated and compensated inside the torque sharing function. The adapting TSF is compensates for the torque fault with receiving the phase because it is the minimal flux rate connecting variation. Finally, the jellyfish search technique is accepted to determine the optimal control parameters. The proposed strategies are done in MATLAB and its performance is contrasted with different existing strategies. According to the simulation result, the proposed strategy‐based accuracy is 94.2% at 50 iteration and 80% at 100th iteration which is higher than the existing methods. From this analyses, it proved that the proposed technique gives superior performance to existing one.
Factors Associated with Head and Neck Cancer Postoperative Radiotherapy Delays: A Systematic Review and Meta‐analysis
Authors: Duckett Kelsey A. , Kassir Mohamed Faisal , Nguyen Shaun A. , Brennan Emily A. , Chera Bhisham S. , Sterba Katherine R. , Halbert Chanita Hughes , Hill Elizabeth G. , McCay Jessica , Puram Sidharth V. , Jackson Ryan S. , Sandulache Vlad C. , Kahmke Russel , Osazuwa‐Peters Nosayaba , Ramadan Salma , Nussenbaum Brian , Alberg Anthony J. , Graboyes Evan M. 
Published: June 2024

AbstractObjectiveInitiating postoperative radiotherapy (PORT) within 6 weeks of surgery for head and neck squamous cell carcinoma (HNSCC) is included in the National Comprehensive Cancer Network Clincal Practice Guidelines and is a Commission on Cancer quality metric. Factors associated with delays in starting PORT have not been systematically described nor synthesized.Data SourcesPubMed, Scopus, and CINAHL.Review MethodsWe included studies describing demographic characteristics, clinical factors, or social determinants of health associated with PORT delay (>6 weeks) in patients with HNSCC treated in the United States after 2003. Meta‐analysis of odds ratios (ORs) was performed on nonoverlapping datasets.ResultsOf 716 unique abstracts reviewed, 21 studies were included in the systematic review and 15 in the meta‐analysis. Study sample size ranged from 19 to 60,776 patients. In the meta‐analysis, factors associated with PORT delay included black race (OR, 1.46, 95% confidence interval [CI]: 1.28‐1.67), Hispanic ethnicity (OR, 1.37, 95% CI, 1.17‐1.60), Medicaid or no health insurance (OR, 2.01, 95% CI, 1.90‐2.13), lower income (OR, 1.38, 95% CI, 1.20‐1.59), postoperative admission >7 days (OR, 2.92, 95% CI, 2.31‐3.67), and 30‐day hospital readmission (OR, 1.37, 95% CI, 1.29‐1.47).ConclusionPatients at greatest risk for a delay in initiating guideline‐adherent PORT include those who are from minoritized communities, of lower socioeconomic status, and experience postoperative challenges. These findings provide the foundational evidence needed to deliver targeted interventions to enhance equity and quality in HNSCC care delivery.
Simultaneous versus Sequential Cochlear Implantation in Adults: Quantitative and Qualitative Outcomes
Authors: Schauwecker Natalie , Patro Ankita , Holder Jourdan , Moberly Aaron C. , Perkins Elizabeth 
Published: June 2024

AbstractObjectiveTo compare speech recognition and quality of life outcomes between bilateral sequentially and simultaneously implanted adult cochlear implant (CI) recipients who initially qualify for a CI in both ears.Study DesignRetrospective chart review.SettingTertiary referral center.MethodsRetrospective chart review identified adults who underwent bilateral CI, either simultaneously or sequentially, at a high‐volume center between 2012 and 2022. Sequentially implanted patients were only included if the second ear qualified for CI in quiet (defined as best‐aided AzBio quiet testing <60%), at time of initial CI evaluation.ResultsOf 112 bilateral CI patients who qualified in both ears at initial evaluation, 95 underwent sequential implantation and 17 simultaneous. Age, duration, and etiology of hearing loss, and CI usage were similar between groups. Preoperatively, the sequential group had lower pure‐tone average (PTA) in the 1st ear than the simultaneously implanted group (P = <.001) but, no difference in 2nd ear PTA (P = .657). Preoperative speech recognition scores were significantly higher for the sequential group; however, this was not true for postoperative scores. There was no difference in the proportion of patients showing significant CI‐only or bilateral performance improvement between the groups. Both groups demonstrated similar benefit in quality of life measures.ConclusionOur findings indicate both simultaneous and sequential cochlear implantation are effective in improving hearing performance and quality of life. Thus, bilateral versus simultaneous implantation should be discussed and tailored for each individual patient.
Hearing Loss: Self‐Reported Onset and Etiology Among Older Adults in the United States
Authors: Gallagher Tyler J. , Russel Ziphron , Choi Janet S. 
Published: June 2024

AbstractThis study investigated self‐reported age of onset and etiology of hearing loss among older adults in the United States. Study cohort included older adult (≥70 years) survey respondents from the 2017 to 2020 National Health and Nutrition Examination Survey (n = 797). Overall, 51.1% [95% confidence interval [CI]: 46.1‐56.1] of older adults self‐reported hearing loss. Among older adults who reported hearing loss, the most reported age of onset was age 70 or older (41.7% [95% CI: 38.1%‐45.3%]), followed by sequentially younger age brackets including ages 60 to 69 years (27.3% [95% CI: 23.6%‐31.3%]) and ages 40 to 59 years (15.7% [95% CI: 12.9%‐19.0%]). The most common etiology of hearing loss was aging (66.3% [95% CI: 60.8%‐71.4%]) followed by loud long‐term noise (30.3% [95% CI: 26.2%‐34.9%]) and loud brief noise (13.8% [95% CI: 10.3%‐18.4%]). Our study describes the most common age of onset and etiologies of hearing loss among a representative sample of United States older adults.
Patient Questions Surrounding Posterior Nasal Nerve Ablation for Chronic Rhinitis
Authors: Gorelik Daniel , Razmi Samuel E. , Sims Robert Kenneth , Dhanda Aatin K. , Takashima Masayoshi , Brissett Ella S. , Rowan Nicholas R. , Yim Michael T. , Khan Najm , Fox Meha G. , Ahmed Omar G. 
Published: June 2024

AbstractObjectiveIn‐office ablation of the posterior nasal nerve (PNN) has emerged as an effective treatment option for chronic rhinitis patients. This study explored questions patients commonly search online regarding this therapy and the quality of content available.Study DesignA retrospective analysis of online search criteria and sources was performed with subsequent analysis of results.SettingSearch and data acquisition was in September of 2023.MethodsMost common search terms related to cryotherapy and radiofrequency neurolysis of the PNN were identified with associated People Also Ask (PAA) questions. Questions were categorized and organized into subtopics and sources evaluated using readability and quality metrics.ResultsA total of 255 unique PAA questions and 175 unique websites were identified. The most common subtopics were related to facts about chronic rhinitis (26.7%) and rhinitis treatment options (25.1%). Nearly a quarter (24.3%) of websites were from commercial sources. Quality metrics indicate difficult‐to‐read and low‐quality materials.ConclusionExisting online resources need improvement to provide patients material that is easier to read. Physicians counseling patients should be aware of these areas for adequate shared decision making.
Eculizumab for management of hyperhemolysis syndrome in pediatric patients with sickle cell disease: A single‐center case series
Authors: Lapite Ajibike , Bhar Saleh , Fasipe Titilope 
Published: June 2024

AbstractChronic hemolytic anemia and vascular occlusion are hallmarks of sickle cell disease (SCD). Blood transfusions are critical for supportive and preventive management of SCD complications. Patients with SCD are at risk for hyperhemolysis syndrome (HHS), a subtype of delayed hemolytic transfusion reactions. HHS management includes intravenous immunoglobulin, corticosteroids, and avoidance of further transfusions. Not all patients respond to first‐line agents. Eculizumab, which blocks terminal complement activation, has been proposed as second‐line management of HHS. We describe two patients who received eculizumab for refractory HHS. In our experience, eculizumab is a safe and effective option for refractory pediatric HHS.
“A very difficult conversation”: Challenges and opportunities for improvement in pediatric oncology clinician communication about late effects
Authors: Carpenter Kendall , Revette Anna C. , Scavotto Madison , Mack Jennifer W. , Greenzang Katie A. 
Published: June 2024

AbstractObjectivesCurrent approaches to communicating the potential late effects of pediatric oncology treatments leave many patients and families feeling unaware of risks and unprepared for the future. We aimed to identify provider perspectives on early communication about late effects.MethodsSemi‐structured interviews were conducted with pediatric oncology providers at Dana‐Farber/Boston Children's Cancer and Blood Disorders Center from December 2021 to March 2022. Purposeful sampling ensured a diversity of clinical roles. Thematic analysis was conducted using deductive and inductive codes.ResultsWe interviewed nine pediatric oncology providers; all expressed discomfort discussing potential late effects in early treatment conversations. Barriers to late effects communication included (i) social‐emotional factors, including lack of perceived importance to families, worry about emotional burden on families, and provider feelings of helplessness/wanting to provide hope; and (ii) suboptimal set‐up/resources, including limitations of consent forms, time constraints, and lack of available data. All providers supported the creation of a communication tool to assist early discussions of late effects.ConclusionsCommunicating about late effect risks poses unique challenges to providers because of the perceived impact on families and the limitations of current practices and available resources. These findings support the need for a late effects communication tool to assist in early communication about late effects risks.