bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating multi‐omics approaches in deciphering atopic dermatitis pathogenesis and future therapeutic directions
Authors: Nakajima Saeko , Nakamizo Satoshi , Nomura Takashi , Ishida Yoshihiro , Sawada Yu , Kabashima Kenji 
Published: June 2024

AbstractAtopic dermatitis (AD), a complex and heterogeneous chronic inflammatory skin disorder, manifests in a spectrum of clinical subtypes. The application of genomics has elucidated the role of genetic variations in predisposing individuals to AD. Transcriptomics, analyzing gene expression alterations, sheds light on the molecular underpinnings of AD. Proteomics explores the involvement of proteins in AD pathophysiology, while epigenomics examines the impact of environmental factors on gene expression. Lipidomics, which investigates lipid profiles, enhances our understanding of skin barrier functionalities and their perturbations in AD. This review synthesizes insights from these omics approaches, highlighting their collective importance in unraveling the intricate pathogenesis of AD. The review culminates by projecting future trajectories in AD research, particularly the promise of multi‐omics in forging personalized medicine and novel therapeutic interventions. Such an integrated multi‐omics strategy is poised to transform AD comprehension and management, steering towards more precise and efficacious treatment modalities.
Same therapy, same calcium mobilization? Exploring calcium exchange across body compartments using a patient‐specific predictive model
Authors: Balsamello Carlo , Mas Mar Martinez , Rombolà Giuseppe , Floreani Riccardo , Costantino Maria Laura , Casagrande Giustina 
Published: June 2024

AbstractBackgroundComprehensive, patient‐specific models are essential to study calcium deposition and mobilization during dialysis. We aim to develop tools to support clinical prescriptions with a more accurate approach for the prediction of calcium mobilization while also considering major electrolytes and catabolites.MethodsWe modified a multi‐solute model predicting patient‐specific dialysis response by incorporating a calcium buffer to represent bone exchanges. Data from four centers, involving 127 patients with six sessions each, were utilized. For each patient, three sessions were allocated for model training (ID123), while the remaining sessions were for validation (PRED456). The normalized root mean square error (nRMSE%) was used to evaluate both descriptive and predictive accuracy. Correlations between initial data and calcium exchanges were also assessed.ResultsThe overall nRMSE% for ID123 was 3.92%. For PRED456, it was 3.46% (ranging from a minimum of 1.17% for [Na+] to a maximum of 6.62% for [urea]). The median nRMSE% for plasma calcium varied between 1.13 and 8.32 for SHD sessions, depending on whether Ca_dialysis fluid (Cad) was ≥ or <1.50 mmol/L, respectively. For HDF sessions, the range was between 2.90 and 5.89. A significant and moderate correlation was found between overall calcium removal and the buffer balance. The most robust correlation observed was between the amount of calcium administered via post‐dilution fluid and the overall calcium removal in the dialysis filter.ConclusionsIdentical therapy settings do not uniformly affect calcium mobilization, and our approach offers insight into calcium distribution across body compartments. This understanding will enhance clinical prescription practices.
A new technique for the treatment of ureteric stricture after kidney transplantation
Authors: Gao Xiaoshuai , Wang Wei , Li Fei , Peng Liao , Di Xingpeng , Chen Jixiang , Wei Xin 
Published: June 2024

ObjectiveTo evaluate the safety and effectiveness of endoscopic treatments with Allium® metal ureteric stent (AMUS) for ureteric strictures after kidney transplantation (KT).Patients and MethodsIn a prospective manner, we gathered clinical data from 68 patients who underwent endoscopic treatments with AMUS for ureteric strictures after KT between January 2019 and March 2022. The definition of surgical success was the unobstructed drainage of the AMUS, or in cases where there was AMUS migration, occlusion or encrustation and subsequently removed, there is no worsening of renal hydronephrosis in the patient during the follow‐up period.ResultsBased on the specific circumstances of the ureteric strictures, three distinct types of surgery were selected for treatment. The overall success rate of endoscopic treatments for ureteric strictures following KT was 90% (61/68) during a follow‐up period of 1 year. Surgical complications included haematuria (18%), pain (10%), urinary tract infections (7.4%), and lower urinary tract symptoms (7.4%). The incidences of stent migration, occlusion, and encrustation were 10%, 2.9%, and 1.5%, respectively. Postoperatively, significant improvements were observed in various parameters. At 1 month after surgery, there was a notable decrease in blood creatinine levels (105.5 vs 90.4 mol/L), urea nitrogen levels (6.6 vs 5.4 mmol/L), and hydronephrosis volume (64.4 vs 43.9 mL). Additionally, the serum estimated glomerular filtration rate increased from 49.5 to 64.4 mL/min/1.73 m2. The follow‐up results of patients at 1 year after surgery were similar to those observed at 1 month after surgery.ConclusionsSystemic endoscopic treatments with AMUS were found to be safe and effective for ureteric strictures after KT with short‐term follow‐ups. This technique offers a novel option for the treatment of post‐KT strictures.
Mechanical performance of patient‐specific prefabricated temporary shell versus laboratory‐fabricated CAD/CAM provisional implant‐supported single‐tooth restorations: A laboratory study
Authors: Donker Vincent J. J. , Janss Paulien E. A. , Pol Christiaan W. P. , Raghoebar Gerry M. , Vissink Arjan , Meijer Henny J. A. 
Published: June 2024

AbstractObjectiveTo evaluate the mechanical performance of patient‐specific prefabricated temporary shell versus laboratory‐fabricated CAD/CAM provisional restorations on titanium temporary abutments, with and without thermo‐mechanical ageing.Materials and MethodsImplants with a conical connection were divided into four groups (n = 24) and restored with temporary shell or laboratory‐fabricated central or lateral incisor PMMA restorations that were relined or bonded on titanium temporary abutments. The diameter of the central and lateral incisor groups' implants was regular (ϕ 4.3 mm) or narrow (ϕ 3.5 mm), respectively. Half of each group's specimens were subjected to ageing, simultaneous thermocycling (5–55°C) and chewing simulation (120,000 cycles, 50 N, 1.7 Hz) resulting in eight groups in total (n = 12). The aged specimens were evaluated with optical microscopy, and survival and complication rates were determined according to modified USPHS criteria. The non‐aged specimens and those that had survived ageing were loaded until failure, whereupon bending moments were calculated.ResultsSurvival rates after ageing were 100% for all groups. Apart from wear facets (ϕ 2–3 mm) on the palatal restoration surface, no complications were observed. The mean fracture load and bending moments ranged between 597.6–847.1 N and 433.3–550.6 Ncm, respectively, with no significant differences between the eight groups (p = .25; p = .20).ConclusionsAs patient‐specific temporary shell central and lateral incisor provisional implant‐supported restorations are mechanically stable enough to withstand clinical bite forces, even after thermo‐mechanical ageing, they may serve as an alternative to laboratory‐fabricated provisional restorations.
Enhancing guided bone regeneration with cross‐linked collagen‐conjugated xenogeneic bone blocks and membrane fixation: A preclinical in vivo study
Authors: An Yin‐Zhe , Song Young Woo , Thoma Daniel S. , Strauss Franz J. , Lee Jung‐Seok 
Published: June 2024

AbstractObjectiveTo determine whether combining cross‐linked (CL) collagen‐integrated xenogeneic bone blocks stabilized with the fixation of resorbable collagen membranes (CM) can enhance guided bone regeneration (GBR) in the overaugmented calvarial defect model.Materials and MethodsFour circular defects with a diameter of 8 mm were prepared in the calvarium of 13 rabbits. Defects were randomly assigned to receive one of the following treatments: (i) non‐cross‐linked (NCL) porcine‐derived collagen‐embedded bone block covered by a CM without fixation (NCL + unfix group); (ii) NCL bone block covered by CM with fixation using bone‐tack (NCL + fix group); (iii) cross‐linked (CL) porcine‐derived collagen‐embedded bone block covered by CM without fixation (CL + unfix group); and (iv) CL bone block covered by CM with fixation using bone‐tack fixation (CL + fix group). The efficacy of GBR was assessed through histological and molecular analyses after 2 and 8 weeks.ResultsAt 2 weeks, there were no significant differences in histologically measured areas of newly formed bone among the groups. At 8 weeks, however, the CL + fix group exhibited a larger area of new bone (5.08 ± 1.09 mm2, mean ± standard deviation) compared to the NCL + unfix (1.62 ± 0.42 mm2; p < .0083), NCL + fix (3.97 ± 1.39 mm2) and CL + unfix (2.55 ± 1.04 mm2) groups. Additionally, the expression levels of tumour necrosis factor‐alpha, fibroblast growth factor‐2, vascular endothelial growth factor, osteocalcin and calcitonin receptor were significantly higher in the CL + fix group compared to the other three groups (p < .0083).ConclusionCross‐linked bone blocks stabilized with collagen membrane fixation can significantly enhance GBR.
Solar photovoltaic energy development and biodiversity conservation: Current knowledge and research gaps
Authors: Gómez‐Catasús Julia , Morales Manuel B. , Giralt David , del Portillo David González , Manzano‐Rubio Robert , Solé‐Bujalance Laura , Sardà‐Palomera Francesc , Traba Juan , Bota Gerard 
Published: June 2024

AbstractSolar photovoltaic (PV) has become the second renewable energy source, giving rise to potential conflicts with biodiversity conservation. However, the information available about the impacts and mitigation measures of solar PV energy is scarce and scattered, and a rigorous and comprehensive review on the topic is lacking. Here, we review the state of knowledge on its impacts and mitigation measures and identify main knowledge gaps. For that, we reviewed more than 2000 articles, out of which only 180 assessed the impacts of solar PV (N = 138) and/or propose mitigation measures (65). Even though Asia and Europe head the list of regions with the highest PV installed capacity (59% and 22%, respectively), a large portion of the existing knowledge is drawn from North American environmental contexts (48% of the studies), specifically from deserts (41%). Impacts were addressed on plants (26%), arthropods (14%), birds (10%), microorganisms (10%), reptiles (7%), mammals (4%), and bats (1%), but also on abiotic factors (e.g., humidity and temperature; 20%) and ecosystem services (3%). Most studies addressed the impact of PV on habitat alteration at landscape (33%) and microhabitat scale (20%), and on microclimate at microhabitat scale (17%), but other topics have been scarcely addressed (e.g., impact on microclimate at landscape scale or the potential of agrivoltaic systems). Lastly, 53% of the studies employed a single PV facility, and preconstruction situations were rarely reported (8%). There is a strong environmental context bias in the current understanding of PV impacts, which might not be extrapolable to other environmental situations like farmlands, where most of the solar PV capacity is being installed. Moreover, standardized and robust sampling designs are lacking to address cumulative, long‐term, and long‐scale impacts and produce comparable findings across contexts. Given the lack of empirical evidence and the irrepressible development of PV energy, it is advisable to apply an iterative monitoring and adaptive process to guarantee a safe energy transition. This review may provide useful guidance on prioritizing research efforts for a smooth shift to renewable energy.
Extrafacial lentigo maligna: A progression model and enhanced diagnostic techniques using dermatoscopy and reflectance confocal microscopy
Authors: Griffiths Acha Joseph , Gamo Villegas Reyes , Floristán Murúzabal Uxua , Pampín Franco Ana , Sarró Fuente Claudia , Pinedo Moraleda Fernando , López Estebaranz Jose Luis 
Published: June 2024

AbstractLentigo maligna (LM) is a subtype of lentiginous melanoma confined to the epidermis, which is associated with chronic sun exposure. Its clinical, dermatoscopic, and histopathological diagnosis can be challenging, particularly in the early and advanced stages, requiring appropriate clinicopathological correlation. This article reviews the clinical presentation, diagnosis through noninvasive methods (dermoscopy and confocal microscopy), and provides insights for diagnosis of extrafacial LM through the presentation of four representative clinical cases from different phases of a theoretical–practical progression model. Recognizing these lesions is crucial, as once they invade the dermis, they can behave like any other type of melanoma.
Delayed diagnosis of Loeys‐Dietz syndrome revealed through atrial septal defect with pulmonary artery dilation
Authors: Zamora Karina Del Valle , Fernandez‐Sandoval Maria Fernanda , Quiroz‐Martinez‐Martinez Victor Alejandro , Vera‐Chavez Jacobo Sebastian , Martinez‐Dominguez Pavel , Espinola‐Zavaleta Nilda 
Published: June 2024

AbstractLoeys‐Dietz syndrome (LDS) is an autosomal‐dominant connective tissue disorder associated with mutations in the transforming growth factor β receptor. It is characterized by distinctive craniofacial changes, skeletal features, and cardiovascular complications. We present a case of a 24‐year‐old male with development delay and a one‐year history of progressively worsening dyspnea on moderate exertion and orthopnea. Echocardiography revealed right atrial and right ventricle dilation, right ventricle hypertrophy, atrial septal defect, and aneurysmal dilation of the pulmonary artery trunk. This case underscores the importance of early detection and comprehensive imaging in patients suspected of having LDS, particularly considering the potential for atypical vascular manifestations.
Left atrial function in middle‐aged men and women with and without paroxysmal atrial fibrillation: Data from the Akershus Cardiac Examination (ACE) 1950 study
Authors: Solberg Magnar G. , Enger Steve , Berge Trygve , Rønningen Peter S. , Aagaard Erika N. , Pervez Mohammad Osman , Orstad Eivind B. , Kvisvik Brede , Lyngbakken Magnus N. , Røsjø Helge , Steine Kjetil , Tveit Arnljot 
Published: June 2024

AbstractPurposeTo assess left atrial (LA) function in individuals with known paroxysmal atrial fibrillation (AF) compared with healthy and nonhealthy individuals without atrial fibrillation.MethodsThe Akershus Cardiac Examination 1950 Study included 3,706 individuals all born in 1950. LA strain assessment of reservoir (LASr), conduit (LAScd) and contractile (LASct) functions were performed in all participants by investigators blinded to clinical data. Participants with cardiovascular disease, obesity, diabetes, pulmonary or renal disease were defined as nonhealthy, and those without as healthy. Patients with paroxysmal AF were identified through medical history and ECG documentation.ResultsLA strain assessment was feasible in 3,229 (87%) of the participants (50% women). The healthy group (n = 758) had significantly higher LASr and LAScd than the nonhealthy (n = 2,376), but LASct was similar between the groups. Participants with paroxysmal AF had significantly lower values of all strain parameters than the other groups. Multivariable logistic regression showed a significantly reduced probability of having AF per standard deviation increase in LASr and LASct. A nonlinear restricted cubic spline model fitted better with the association of LASr with paroxysmal AF than the linear model, and LA strain values below the population mean associated with an increased probability of having AF, but for values above the population mean no such association was present.ConclusionCompared to participants without AF, those with known paroxysmal AF had significantly lower values of all LA strain parameters during sinus rhythm. Lower values of LA strain were associated with a significantly increased probability of having AF.
Suicidal ideation in adolescents with adiponectin receptor 2 rs12342 polymorphism affected by Wenchuan earthquake
Authors: Cai Jia Jing , Zheng Ping , Su Mi , Shen Yi Lin , Li Xue Cheng , Guo Qi Wei , Chen Xu , Su Guo Ming , Lin Jia , Gong Ren Rong , Fang Ding Zhi 
Published: June 2024

AbstractPurposeThe present study was to investigate prevalence of suicidal ideation and its associations with biological and environmental factors in adolescents with different genotypes of rs12342 at adiponectin receptor 2 gene (ADIPOR2).MethodsSuicidal ideation, biological and environmental factors were evaluated by questionnaires in 669 high school students after Wenchuan earthquake in China. ADIPOR2 rs12342 was genotyped by polymerase chain reaction‐restriction fragment length polymorphism and verified by DNA sequencing.ResultsFemale adolescents had higher prevalence of suicidal ideation than male students in AG heterozygote and GG homozygote, but not AA homozygote. Prevalence of suicidal ideation was different in male, but not female, subjects with different genotypes. Genotype and allele frequencies were significantly different between male students with and without suicidal ideation, but not the female counterparts. Family history of mental disorders, extent of damage to property, carbohydrate intake and protein intake were associated with suicidal ideation in female subjects, while ADIPOR2 rs12342, father's educational level and previous trauma experience were associated with suicidal ideation in male subjects.Conclusion
ADIPOR2 rs12342 is associated with and has potential to interact with environmental factors on suicidal ideation in a gender‐dependent manner in youth. These findings pave a novel way and perspective for precision inferences of suicidal ideation in subjects with different genetic backgrounds. ADIPOR2 rs12342 needs to be considered when intervening suicidal ideation, especially in adolescents.
Listen to the parents: Homeschooling and positive psychology
Authors: Guterman Oz , Rodriguez Lindsey M. 
Published: June 2024

AbstractThe scope of homeschooling has increased significantly in recent years in several western countries. Studies of the subject have shed light on the perspective of parents who choose to homeschool–reasons for the choice, educational goals and actual results– from their point of view. The research literature also teaches us about the perspectives of kids and adolescents who were raised in homeschooling regarding the same questions. Understanding these points of view indicates certain aspects that those who are educated at home perceive as most central. Some of the subjects included in these aspects are also central to the research on positive psychology, a field that has developed over the same period. The present article presents the findings regarding these aspects in the study of homeschooling and suggests possible links between them and the development of research on positive psychology. The article indicates several similarities and examines the possible theoretical and methodological contributions of a broader perspective of the two fields, as well as the potential benefit to the study of homeschooling in identifying the reasons for homeschooling, examining the results of homeschooling, and understanding the practice of families that homeschool.
Comparative effectiveness and tolerability of calcitonin gene‐related peptide (CGRP) monoclonal antibodies and onabotulinumtoxinA in chronic migraine: A multicenter, real‐world study in Taiwan
Authors: Wang Yen‐Feng , Yang Fu‐Chi , Chen Lu‐An , Chang Ting‐Yu , Su Hui‐Chen , Yang Chun‐Pai , Tu Yi‐Hsien , Tzeng Yi‐Shiang , Chen Shih‐Pin , Fuh Jong‐Ling , Lai Kuan‐Lin , Ling Yu‐Hsiang , Chen Wei‐Ta , Wang Shuu‐Jiun 
Published: June 2024

AbstractObjectiveTo compare the real‐world effectiveness and tolerability of calcitonin gene‐related peptide (CGRP) monoclonal antibodies (mAbs) and onabotulinumtoxinA in chronic migraine (CM) patients.MethodsThis multicenter study involved retrospective analysis of prospectively collected data of CM patients treated with CGRP mAbs or onabotulinumtoxinA, including difficult‐to‐treat (DTT) patients (i.e., ≥3 preventive failures). Treatment outcomes were determined at 6 months based on prospective headache diaries and Migraine Disability Assessment (MIDAS).ResultsThe study included 316 (55 M/261F, mean age 44.4 ± 13.5 years) and 333 (61 M/272F, mean age 47.9 ± 13.4 years) CM patients treated with CGRP mAbs or onabotulinbumtoxinA, respectively. At 6 months, CGRP mAb treatment was associated with a greater decrease in monthly migraine days (MMDs) (−13.0 vs. −8.7 days/month, p < 0.001) and a higher ≥50% responder rate (RR) (74.7% vs. 50.7%, p < 0.001) compared with onabotulinumtoxinA injections. The findings were consistent in DTT patients (−13.0 vs. −9.1 MMDs, p < 0.001; ≥50% RR: 73.9% vs. 50.3%, p < 0.001) or those with medication‐overuse headache (MOH) (−13.3 vs. −9.0 MMDs, p < 0.001; ≥50% RR: 79.0% vs. 51.6%, p < 0.001). Besides, patients receiving CGRP mAbs had greater improvement (−42.2 vs. −11.8, p < 0.001) and a higher ≥50% RR (62.0% vs. 40.0%, p = 0.001) in MIDAS scores and a lower rate of adverse events (AEs) (6.0% vs. 21.0%, p < 0.001). However, none of the patients discontinued treatment due to AEs.ConclusionsIn this multicenter, real‐world study, CGRP mAbs were more effective than onabotulinumtoxinA in CM patients, even in DTT or MOH patients. All of these injectables were well tolerated. Further prospective studies are needed to verify these findings.
Is everyone traumatized? Perspectives from an Indonesian convent
Authors: Donnelly Meghan Rose 
Published: June 2024

AbstractWhat if we took trauma to be a fundamental aspect of human existence? Prominent in some strands of popular psychology, this is also the stance taken by an eastern Indonesian order of Catholic nuns who “dig up” their hearts as part of a continual process of self‐formation. Set against a backdrop of Christian theologies of discernment, state concerns for human development, and local resonances of ritual sacrifice, nuns learn to interpret their childhoods as harmed by emotional trauma sustained in the company of kin. Once excavated, this trauma must be addressed in the convent through conscious efforts of mutual care, making trauma a moral category that creates new forms of subjectivity. Through acts of acknowledgment and support, the idiom of trauma makes the company surrounding a nun directly responsible for her self‐formation. This article is about the ways Indonesian Catholic nuns conceptualize trauma as something that all humans sustain, how it grounds self‐becoming, and how its causes—and cures—are rooted in the company of other people. I suggest that their experiences highlight the sociality of trauma more broadly and argue that trauma is one articulation of how people become themselves in the company of others.