bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficient Hydrogen Evolution from Dimethylamine Borane, Ammonia Borane and Sodium Borohydride Catalyzed by Ruthenium and Platinum Nanoparticles Stabilized by an Amine Modified Polymer Immobilized Ionic Liquid: a Comparative Study
Authors: Alharbi Adhwa A. , Wills Corinne , Dixon Casey , Arca Elisabetta , Chamberlain Thomas W. , Griffiths Anthony , Collins Sean M. , Wu Kejun , Yan Han , Bourne Richard A. , Knight Julian G. , Doherty Simon 
Published: June 2024

AbstractPlatinum and ruthenium nanoparticles stabilised by an amine modified polymer immobilised ionic liquid (MNP@NH2-PEGPIILS, M = Pt, Ru) catalyse the hydrolytic liberation of hydrogen from dimethylamine borane (DMAB), ammonia borane (AB) and NaBH4 under mild conditions. While RuNP@NH2-PEGPIILS and PtNP@NH2-PEGPIILS catalyse the hydrolytic evolution of hydrogen from NaBH4 with comparable initial TOFs of 6,250 molesH2.molcat−1.h−1 and 5,900 molesH2.molcat−1.h−1, respectively, based on the total metal content, RuNP@NH2-PEGPIILS is a markedly more efficient catalyst for the dehydrogenation of DMAB and AB than its platinum counterpart, as RuNP@NH2-PEGPIILS gave initial TOFs of 8,300 molesH2.molcat−1.h−1 and 21,200 molesH2.molcat−1.h−1, respectively, compared with 3,050 molesH2.molcat−1.h−1 and 8,500 molesH2.molcat−1.h−1, respectively, for PtNP@NH2-PEGPIILS. Gratifyingly, for each substrate tested RuNP@NH2-PEGPIILS and PtNP@NH2-PEGPIILS were markedly more active than commercial 5wt % Ru/C and 5wt% Pt/C, respectively. The apparent activation energies of 55.7 kJ mol−1 and 27.9 kJ mol−1 for the catalytic hydrolysis of DMAB and AB, respectively, with RuNP@NH2-PEGPIILS are significantly lower than the respective activation energies of 74.6 kJ mol−1 and 35.7 kJ mol−1 for its platinum counterpart, commensurate with the markedly higher initial rates obtained with the RuNPs. In comparison, the apparent activation energies of 44.1 kJ mol−1 and 46.5 kJ mol−1, for the hydrolysis NaBH4 reflect the similar initial TOFs obtained for both catalysts. The difference in apparent activation energies for the hydrolysis of DMAB compared with AB also reflect the higher rates of hydrolysis for the latter. Stability and reuse studies revealed that RuNP@NH2-PEGPIILS recycled efficiently as high conversions for the hydrolysis of DMAB were maintained across five runs with the catalyst retaining 97% of its activity.
Graphical Abstract
Deoxynivalenol induces m6A-mediated upregulation of p21 and growth arrest of mouse hippocampal neuron cells in vitro
Authors: Xu Peirong , Zhao Yulan , Feng Yue , Zhao Mindie , Zhao Ruqian 
Published: June 2024

AbstractHippocampal neurons maintain the ability of proliferation throughout life to support neurogenesis. Deoxynivalenol (DON) is a mycotoxin that exhibits brain toxicity, yet whether and how DON affects hippocampal neurogenesis remains unknown. Here, we use mouse hippocampal neuron cells (HT-22) as a model to illustrate the effects of DON on neuron proliferation and to explore underlying mechanisms. DON exposure significantly inhibits the proliferation of HT-22 cells, which is associated with an up-regulation of cell cycle inhibitor p21 at both mRNA and protein levels. Global and site-specific m6A methylation levels on the 3’UTR of p21 mRNA are significantly increased in response to DON treatment, whereas inhibition of m6A hypermethylation significantly alleviates DON-induced cell cycle arrest. Further mechanistic studies indicate that the m6A readers YTHDF1 and IGF2BP1 are responsible for m6A-mediated increase in p21 mRNA stability. Meanwhile, 3’UTR of E3 ubiquitin ligase TRIM21 mRNA is also m6A hypermethylated, and another m6A reader YTHDF2 binds to the m6A sites, leading to decreased TRIM21 mRNA stability. Consequently, TRIM21 suppression impairs ubiquitin-mediated p21 protein degradation. Taken together, m6A-mediated upregulation of p21, at both post-transcriptional and post-translational levels, contributes to DON-induced inhibition of hippocampal neuron proliferation. These results may provide new insights for epigenetic therapy of neurodegenerative diseases.
Graphical abstract
DON inhibits the proliferation of HT-22 cells.
RNA m6A hypermethylation on the transcript of p21 enhances the mRNA stability in a YTHDF1- and IGF2BP1-dependent manner, which leads to the upregulation of p21.
RNA m6A hypermethylation on the transcript of TRIM21 decreases the mRNA stability in a YTHDF2-dependent manner, which contributes to prevent p21 ubiquitin-mediated degradation.
High expression of p21 contributes to inhibit cell proliferation.
Evaluating the Experience of Teen-to-Teen Crisis Line Volunteers: A Pilot Study
Authors: Glenn Catherine R. , Kalgren Taylor , Dutta Sandipan , Kandlur Raksha , Allison Kelsie K. , Duan Annie , Eskin Cheryl Karp , Leets Morgan , Gould Madelyn S. 
Published: June 2024

AbstractTeen-to-teen (t2t) crisis lines are a special type of crisis service where youth volunteers help their peers. Although prior research has examined the experience of adult crisis line responders, no research has examined the experience of adolescents who do this work. In collaboration with two of the largest t2t lines in the U.S., this pilot study is the first examination of t2t crisis line work. Volunteers (ages 14–20) reported: their primary motivation for joining the crisis lines was to help others and give back to the community; responding to a range of peers’ problems on the t2t crisis line, including high-risk suicide contacts; and a range of ways the crisis line work impacted their lives. Findings provide preliminary information about the experience of adolescents engaging in t2t crisis line work. Additional research is needed in larger and more diverse samples to understand the impact of crisis line work for youth.
Revitalising learning in three university contexts: Unleashing the power of the Quizizz app to increase self-efficacy, intrinsic motivation, satisfaction and performance
Authors: Hernanz Virginia , Latorre-Cosculluela Cecilia , Suárez Cristina , Lanchares-Sancho Elena 
Published: June 2024

AbstractConsidering the innovative learning approach of incorporating gamification educational dynamics, this study focused on analyzing differences in the effects of using Quizizz depending on the degree of practical focus that different university degrees have. By applying game elements in non-game contexts, gamification has been recognized as a strategy that can increase student motivation and engagement. After applying the four-month innovation experience in three degree programs (Engineering, Business Administration, and Education), the perceptions of the 179 participating students were evaluated regarding intrinsic motivation, self-efficacy in learning, satisfaction with the use of applications to gamify learning and academic performance. Furthermore, possible differences in these dimensions were explored depending on the degree of practical orientation that each university degree has. The results suggest that students in the educational area express more favorable perceptions about the improvement of their learning with this gamification experience, while Business Administration students are those who express the worst perceptions. The implications of these results are discussed considering the influence that variables such as the active and participatory role of students, the usefulness of the content in the professional future, or the conceptual and theoretical nature of each university degree can exert.
Applying the 6E learning by design model to support student teachers to integrate artificial intelligence applications in their classroom
Authors: Saimon Musa , Mtenzi Fredrick , Lavicza Zsolt , Fenyvesi Kristóf , Arnold Maik , Diego-Mantecón José Manuel 
Published: June 2024

AbstractThe 6E Learning by Design (LbD) model can enhance student teachers’ development of competence for integrating technologies in the classrooms including Artificial Intelligence (AI). However, teacher educators rarely use the 6E LbD model in supporting and encouraging student teachers to integrate AI applications in their classrooms effectively. To attract teacher educators to use the 6E LbD model, in the present study, we modeled learning activities for each phase. We also examined the impact of the 6E LbD model in supporting student teachers to integrate AI in the classroom. We adopted a Participatory Action Research approach implemented in two cycles. We collected data from 35 student teachers who were selected purposively. We collected data through observation, reflective journals and document analysis. We observed student teachers during the classroom activities and analysed their lesson plans and reflective journals, and interpreted data based on a thematic analysis. Findings show that there are various activities facilitating learning in different phases of the 6E LbD model. Also, findings show that the 6E LbD enables student teachers to develop skills and competence for integrating AI in their classrooms. The findings show that an evidence-based approach will motivate teacher educators to use the 6E LbD model.
Temperature and Cognitive Performance: Evidence from Mental Arithmetic Training
Authors: Krebs Benjamin 
Published: June 2024

AbstractWith rising average temperatures and extreme heat events becoming more frequent, understanding the ramifications for cognitive performance is essential. I estimate the effect of outside air temperature on performance in mental arithmetic training games. Using data from 31,000 individuals and 1.15 million games played, I analyze frequent engagement in a cognitively challenging task in a non-stressful and familiar environment. I find that, above a threshold of 16.5 $$^{\circ }$$

∘

C, a 1 $$^{\circ }$$

∘

C increase in outside air temperature leads to a performance reduction of 0.13%. The effect is mostly driven by individuals living in relatively cold areas, who are less adapted to hot temperatures.
Predictive Pattern of Undrained Shear Strength in Stabilized Sulfur Rich Silty Soil Based on Binder and Initial Mixing Water Content
Authors: Zigharib Alaleh , Jia Qi , Macsik Josef , Laue Jan , Maurice Christian 
Published: June 2024

AbstractA laboratory investigation was conducted to identify principal variables-initial mixing water content, porosity, and binder content- impacting undrained shear strength (qu) of stabilized sulfur-rich silty soil. An equation for predicting qu of stabilized soil was established based on the experimental data. Initially, samples were prepared with soils sample with different initial water and binder contents. Multicem, a binder consisting of a mix of cement and cement kiln dust, was added to the samples. Three different percentages of Multicem were mixed at five different soil water contents to measure qu of stabilized mixtures to understand how water content and porosity levels in the samples affect the performance of the binder and their combined impact on the strength of the samples. The soil-binder mixtures were compacted and subsequently cured in laboratory-controlled environment. The prepared samples were tested in uniaxial compression test apparatus. The results evidenced that binder content and corresponding porosity affect the strength of specimens at an equal water content. The results showed that at equal initial mixing water content, the qu of a sample increased by increasing binder content. Furthermore, it was observed that increase of binder content has a reverse effect on porosity. It was appeared lowering the soil water content, initially increased the strength until an optimum water content. Further lowering water content increased the porosity and consequently decreased qu of samples. Moreover, a ratio of porosity/volumetric binder content was chosen to evaluate the impact of these two variables on strength of samples. This study showed that qu is an exponential function of porosity/binder volumetric content ratio which depends on initial mixing water content of mixtures. It was shown at water content lower than the optimum, results of stabilization are more effective than in soil at higher water contents. Therefore, reducing the water content and thereby porosity has more significant effect on improving qu than increasing the binder content.
Spatial inequality in the accessibility of healthcare services in the Philippines
Authors: Leyso Novee Lor , Umezaki Masahiro 
Published: June 2024

AbstractEnsuring equitable access to healthcare is important for universal health coverage (UHC). Using the enhanced two-step floating catchment area (E2SFCA) method, we found disparities in the spatial accessibility of outpatient and inpatient healthcare facilities in the Philippines, particularly in the central and southern regions of the country. Municipalities with a higher proportion of older people had better spatial accessibility to outpatient care, while municipalities with a higher density of older people had better accessibility to inpatient care. Municipalities with high poverty rates had better accessibility to outpatient care but poorer accessibility to inpatient care. Addressing these disparities is essential for achieving UHC in the Philippines.
Reflecting on the Science of Climate Tipping Points to Inform and Assist Policy Making and Address the Risks they Pose to Society
Authors: Stocker T. F. , Jones R. G. , Hegglin M. I. , Lenton T. M. , Hegerl G. C. , Seneviratne S. I. , van der Wel N. , Wood R. A. 
Published: June 2024

AbstractThere is a diverging perception of climate tipping points, abrupt changes and surprises in the scientific community and the public. While such dynamics have been observed in the past, e.g., frequent reductions of the Atlantic meridional overturning circulation during the last ice age, or ice sheet collapses, tipping points might also be a possibility in an anthropogenically perturbed climate. In this context, high impact—low likelihood events, both in the physical realm as well as in ecosystems, will be potentially dangerous. Here we argue that a formalized assessment of the state of science is needed in order to establish a consensus on this issue and to reconcile diverging views. This has been the approach taken by the Intergovernmental Panel on Climate Change (IPCC). Since 1990, the IPCC has consistently generated robust consensus on several complex issues, ranging from the detection and attribution of climate change, the global carbon budget and climate sensitivity, to the projection of extreme events and their impact. Here, we suggest that a scientific assessment on tipping points, conducted collaboratively by the IPCC and the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services, would represent an ambitious yet necessary goal to be accomplished within the next decade.
Evaluation of Storage Placement in Computing Continuum for a Robotic Application
Authors: Bakhshi Zeinab , Rodriguez-Navas Guillermo , Hansson Hans , Prodan Radu 
Published: June 2024

AbstractThis paper analyzes the timing performance of a persistent storage designed for distributed container-based architectures in industrial control applications. The timing performance analysis is conducted using an in-house simulator, which mirrors our testbed specifications. The storage ensures data availability and consistency even in presence of faults. The analysis considers four aspects: 1. placement strategy, 2. design options, 3. data size, and 4. evaluation under faulty conditions. Experimental results considering the timing constraints in industrial applications indicate that the storage solution can meet critical deadlines, particularly under specific failure patterns. Comparison results also reveal that, while the method may underperform current centralized solutions in fault-free conditions, it outperforms the centralized solutions in failure scenario. Moreover, the used evaluation method is applicable for assessing other container-based critical applications with timing constraints that require persistent storage.
Making tacit knowledge explicit: the case for online peer feedback in the studio critique
Authors: Fleischmann Katja 
Published: June 2024

AbstractDesign education traditionally centers around the critique as a pivotal assessment process, fostering the development of both explicit and tacit knowledge within the physical studio environment. Ideally, the critique encourages students to develop their creativity, sharpen their thought processes and refine their technique. This study contributes to the ongoing discourse on technology-enhanced teaching in practice-based design studios by examining the effectiveness of online peer critique as a strategy to capture tacit knowledge and make it explicit in the design learning environment. Drawing on the experiences of 90 undergraduate visual communication design students, findings show the critique process was a collaborative experience which afforded the fluid exchange of both tacit and explicit knowledge. Technology played a key role in this knowledge exchange, giving students a confidence in their creative abilities as observers and participants. The online process facilitated anonymity, enabling open and honest communication, while digital records supported post-critique reflection. Despite challenges, this systematic approach to online peer critique proves beneficial in fully online courses and warrants exploration in physical design studios given that more programs transitioning to blended learning. This research contributes to the discourse on leveraging technology for tacit knowledge construction and learning in design education.
The finding of anisotropic compatibility of grain boundaries in a directionally solidified superalloy
Authors: Tan Yuanguo , Zhang Weiwei , Gao Nong , Reed Philippa 
Published: June 2024

AbstractThe anisotropic compatibility of grain boundaries (GBs) is found in a directionally solidified superalloy, when loading is aligned with (L sample) or transverse (T sample) to the grain growth direction. The greater compatibility of GBs is shown in the L sample by calculating the parameter m′ of the GBs using two developed models. The first model considers the theoretical scenario that grains grow along the perfect [001] orientation, and the compatibility between the neighbouring grains with all kinds of orientation difference is calculated. The second model, termed as Schmid-factor-tolerance model, considers the effects of asymmetrical slip systems caused by the deviation of grain growth direction from the [001] orientation in a real microstructure. Validation of the model is achieved through fatigue tests, demonstrating its capability to interpret and predict the crack initiation behaviours at grain boundaries. Combined with the fatigue tests to illustrate the anisotropic fracture behaviours of the L and T specimens, it shows that the intergranular cracks are more likely to occur in the T specimen with poor compatibility, which proves the capability of predicting the intergranular cracks for the Schmid-factor-tolerance model.
Investigation of miltefosine-model membranes interactions at the molecular level for two different PS levels modeling cancer cells
Authors: Çetinel Züleyha Özçelik , Bilge Duygu 
Published: June 2024

AbstractMiltefosine (MLT) is a broad-spectrum drug included in the alkylphospholipids (APL) used against leishmania and various types of cancer. The most crucial feature of APLs is that they are thought to only kill cancerous cells without harming normal cells. However, the molecular mechanism of action of APLs is not completely understood. The increase in the phosphatidylserine (PS) ratio is a marker showing the stage of cancer and even metastasis. The goal of this research was to investigate the molecular effects of miltefosine at the molecular level in different PS ratios. The effects of MLT on membrane phase transition, membrane orders, and dynamics were studied using DPPC/DPPS (3:1) and DPPC/DPPS (1:1) multilayer (MLV) vesicles mimicking DPPS ratio variation, Differential Scanning Calorimetry (DSC), and Fourier Transform Infrared spectroscopy (FTIR). Our findings indicate that miltefosine is evidence at the molecular level that it is directed towards the tumor cell and that the drug’s effect increases with the increase of anionic lipids in the membrane depending on the stage of cancer.
An Unmet goal? A Scale Development and Model test of the role of Inclusive Leadership
Authors: Merlini Katrina P. , Moon Nicholas A. , McKenzie-James Allyson A. , Caylor Jesse R. , Redmond Alexandria , Nguyen Dan , Richardson Phylicia 
Published: June 2024

Abstract
There is a lack of evidence on whether inclusive leadership (IL) truly fosters inclusion for those in historically marginalized groups. Further, a conceptually up-to-date and practically useful measure of IL is lacking. Thus, in two separate phases, we first present a newly developed measure of IL and then test an empirical model. In Phase 1, results from five demographically diverse samples demonstrate reliability and validity evidence of a 10-item IL scale. In Phase 2, use this scale to examine how IL may support members of historically marginalized groups by fostering (a) interpersonal behaviors that uphold inclusive work environments (allyship, antiracism) and (b) individual experiences of inclusion (workgroup inclusion, authenticity). Path analysis results from a multi-wave study support the influence of IL on these outcomes and also demonstrate support for IL’s indirect effects on outcomes that may be disproportionately high (emotional exhaustion) and low (empowerment) for members of marginalized groups. Moderation analyses reveal many of the hypothesized relationships are similar across groups representing marginalized identities on the bases of race, sex, and the intersection of race and sex. These results add evidence to the importance of IL for fostering inclusive workplaces, especially for those who face the greatest barriers to inclusion.
Andreev reflection, Andreev states, and long ballistic SNS junction
Authors: Sonin Edouard 
Published: June 2024

AbstractThe analysis in the present paper is based on the most known concept introduced by the brilliant physicist Alexander Andreev: Andreev bound states in a normal metal sandwiched between two superconductors. The paper presents results of direct calculations of ab initio expressions for the currents in a long ballistic SNS junction. The expressions are expanded in 1/L (L is the thickness of the normal layer). The main contribution $$\propto 1/L$$

∝
1
/
L

to the current agrees with the results obtained in the past, but the analysis suggests a new physical picture of the charge transport through the junction free from the problem with the charge conservation law. The saw-tooth current-phase relation at $$T=0$$

T
=
0

directly follows from the Galilean invariance of the Bogolyubov–de Gennes equations proved in the paper. The proof is valid for any variation of the energy gap in space if the Andreev reflection is the only scattering process. The respective roles of the contributions of bound and continuum states to the current are clarified. They depend on the junction dimensionality.