bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacist-led medication management services: a qualitative exploration of transition-of-care cardiovascular disease patient experiences
Authors: Bennetts Joshua , White Jennifer , Croft Hayley , Cooper Joyce , McIvor Dawn , Eadie Nicholas , Appay Marcelle , Sverdlov Aaron L , Ngo Doan 
Published: May 2024

ObjectiveHospitalisation due to medication-related problems is a major health concern, particularly for those with pre-existing, or those at high risk of developing cardiovascular disease (CVD). Postdischarge medication reviews (PDMRs) may form a core component of reducing hospital readmissions due to medication-related problems. This study aimed to explore postdischarge CVD patients’ perspectives of, and experiences with, pharmacist-led medication management services. A secondary aim explored attitudes towards the availability of PDMRs.DesignAn interpretative qualitative study involving 16 semistructured interviews. Data were analysed using an inductive thematic approach.SettingPatients with CVD discharged to a community setting from the John Hunter Hospital, an 820-bed tertiary referral hospital based in New South Wales, Australia.ParticipantsPatients with pre-existing or newly diagnosed CVD who were recently discharged from the hospital.ResultsA total of 16 interviews were conducted to reach thematic saturation. Nine participants (56%) were male. The mean age of participants was 57.5 (±13.2) years. Three emergent themes were identified: (1) poor medication understanding impacts transition from the hospital to home; (2) factors influencing medication concordance following discharge and (3) perceived benefits of routine PDMRs.ConclusionsThere is a clear need to further improve the quality use of medicines and health literacy of transition-of-care patients with CVD. Our findings indicate that the engagement of transition-of-care patients with CVD with pharmacist-led medication management services is minimal. Pharmacists are suitable to provide essential and tailored medication review services to patients with CVD as part of a multidisciplinary healthcare team. The implementation of routine, pharmacist-led PDMRs may be a feasible means of providing patients with access to health education following their transition from hospital back to community, improving their health literacy and reducing rehospitalisations due to medication-related issues.
Efficacy and safety of transcutaneous auricular vagus nerve stimulation (ta-VNS) in the treatment of tinnitus: protocol for an updated systematic review and meta-analysis
Authors: Lin Xiaoqi , Fang Yiyan , Hu Hantong , Ye Ziyu 
Published: May 2024

IntroductionWith an increasing incidence and significant effects on patients, tinnitus has become a major disease burden. There is a dearth of therapies with established efficacy for tinnitus. Transcutaneous auricular vagus nerve stimulation (ta-VNS) is being investigated as a potential therapy for tinnitus, but the current body of evidence remains inconclusive due to conflicting results across different studies. As a result, this protocol aims to synthesise and update the evidence to clarify whether ta-VNS is effective and safe for alleviating tinnitus.Methods and analysisTo identify relevant randomised controlled trials (RCTs), seven representative bibliographical databases will be searched from their inception to December 2023: PubMed, Embase (via OVID), Cochrane Library, Chinese National Knowledge Infrastructure, Wangfang Database, Chinese BioMedical Literature Database, and Chongqing VIP Chinese Science and Technology Periodical Database. Publications in English or Chinese will be considered for inclusion. RCTs comparing ta-VNS with active treatments, no intervention, waitlist control or sham ta-VNS in adult patients with subjective tinnitus will be included. Studies on objective tinnitus will be excluded. Primary outcome is tinnitus symptom severity measured by validated scales. With all eligible trials included, when applicable, quantitative analysis via meta-analyses will be performed using RevMan V.5.4.1 software. Otherwise, a qualitative analysis will be conducted. The methodological quality of the included RCTs will be assessed using the Risk of Bias 2.0 tool. Sensitivity analyses, subgroup analysis and publication bias evaluation will also be performed. The Grading of Recommendations, Assessment, Development, and Evaluation approach will be used to grade the certainty of the evidence.Ethics and disseminationEthical approval is not required for this systematic review, as no primary data will be collected. The results will be reported and disseminated through publication in a peer-reviewed journal.PROSPERO registration numberCRD42022351917.
Outcomes of patients with COPD switching from multiple-inhaler to once-daily single-inhaler triple therapy in a real-world primary care setting in England: a retrospective pre-post cohort study
Authors: Rothnie Kieran J , Wood Robert P , Czira Alexandrosz , Banks Victoria L , Camidge Lucinda J , Massey Olivia K I , Seif Monica , Compton Chris , Sharma Raj , Halpin David M G , Ismaila Afisi S , Vogelmeier Claus F 
Published: May 2024

BackgroundCompared with multiple-inhaler triple therapy (MITT), single-inhaler triple therapy (SITT) with fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) demonstrated improved lung function and meaningful improvements in chronic obstructive pulmonary disease (COPD) Assessment Test score. This real-world study compared the effectiveness of switching patients with COPD in England from MITT to once-daily SITT with FF/UMEC/VI by evaluating rates of COPD exacerbation, healthcare resource use (HCRU) and associated direct medical costs.MethodsRetrospective cohort pre-post study using linked primary care electronic health record and secondary care administrative datasets. Patients diagnosed with COPD at age ≥35 years, with smoking history, linkage to secondary care data and continuous GP registration for 12 months pre-switch and 6 months post-switch to FF/UMEC/VI were included. Index date was the first initiation of an FF/UMEC/VI prescription immediately following MITT use from 15 November 2017 to 30 September 2019. Baseline was 12 months prior to index, with outcomes assessed 6/12 months pre-switch and post-switch, and stratified by prior COPD exacerbation status.ResultsWe included 2533 patients (mean [SD] age: 71.1 [9.9] years; 52.1% male). In the 6 months post-switch, there were significant decreases in the proportion of patients experiencing ≥1 moderate-to-severe (36.2%–28.9%), moderate only (24.4%–19.8%) and severe only (15.4%–11.8%) COPD exacerbation (each, p<0.0001) compared with the 6 months pre-switch. As demonstrated by rate ratios, there were significant reductions in exacerbation rates of each severity overall (p<0.01) and among patients with prior exacerbations (p<0.0001). In the same period, there were significant decreases in the rate of each COPD-related HCRU and total COPD-related costs (−24.9%; p<0.0001).ConclusionPatients with COPD switching from MITT to once-daily SITT with FF/UMEC/VI in a primary care setting had significantly fewer moderate and severe exacerbations, and lower COPD-related HCRU and costs, in the 6 months post-switch compared with the 6 months pre-switch.
Digitising the Deep Past: Machine Learning for Rock Art Motif Classification in an Educational Citizen Science Application
Authors: Turner-Jones Richard N. , Tuxworth Gervase , Haubt Robert A. , Wallis Lynley 
Published: May 2024

Digitising the Deep Past (DDP) is an interdisciplinary project based at Griffith University, Australia, that innovates in three areas: Indigenous cultural heritage, Indigenous education, and Machine Learning (ML) and Artificial Intelligence (AI). The project investigates the use of a purpose-built citizen science application that engages Indigenous youth in educational exercises grounded in local cultural heritage, specifically rock art, making learning more engaging and exposing them to digital technologies. Furthermore, ML models trained with the data gathered through these educational activities can then assist with classifying new rock art images and assisting rangers and archaeologists with site archiving and conservation efforts. This article discusses the project’s significance in enhancing Indigenous science and technology education and outlines its results in using ML for rock art classification. Adopting deep learning in rock art classification offers a compelling avenue for the automated analysis and interpretation of heritage objects and places. However, training deep neural networks from scratch often requires enormous datasets and computational resources, posing challenges for domain-specific applications with smaller datasets. With a dataset comprising approximately 3,100 labeled rock art images, we evaluated various tools within the transfer learning toolbox using three prominent pre-trained architectures: VGG19, ResNet50 and EfficientNet V2 S. Through the collaborative efforts of Indigenous students and ML, we demonstrate that even with limited training resources, using transfer learning to re-purpose an existing model can achieve motif classification Top 1 accuracy of 79.76% and Top 5 of 94.56%. The project ran from 2021 to 2023, including 3 week-long sessions with students of Laura State School to trial the citizen science app and the evaluation, development and refinement of the ML models.
The DDP project not only serves as a beacon for community-centric research but also forges a new frontier in integrating Indigenous cultural heritage with modern technology. The impact reaches beyond academia, directly enriching the educational experience for Indigenous students in Laura and equipping local rangers and archaeologists with advanced tools for rock art conservation.
USP44 Overexpression Drives a MYC-Like Gene Expression Program in Neuroblastoma through Epigenetic Reprogramming
Authors: Ekstrom Thomas L. , Hussain Sajjad , Bedekovics Tibor , Ali Asma , Paolini Lucia , Mahmood Hina , Rosok Raya M. , Koster Jan , Johnsen Steven A. , Galardy Paul J. 
Published: May 2024

Abstract
Neuroblastoma is an embryonic cancer that contributes disproportionately to death in young children. Sequencing data have uncovered few recurrently mutated genes in this cancer, although epigenetic pathways have been implicated in disease pathogenesis. We used an expression-based computational screen that examined the impact of deubiquitinating enzymes on patient survival to identify potential new targets. We identified the histone H2B deubiquitinating enzyme USP44 as the enzyme with the greatest impact on survival in patients with neuroblastoma. High levels of USP44 significantly correlate with metastatic disease, unfavorable histology, advanced patient age, and MYCN amplification. The subset of patients with tumors expressing high levels of USP44 had significantly worse survival, including those with tumors lacking MYCN amplification. We showed experimentally that USP44 regulates neuroblastoma cell proliferation, migration, invasion, and neuronal development. Depletion of the histone H2B ubiquitin ligase subunit RNF20 resulted in similar findings, strongly implicating this histone mark as the target of USP44 activity in this disease. Integration of transcriptome and epigenome in analyses demonstrates a distinct set of genes that are regulated by USP44, including those in Hallmark MYC target genes in both murine embryonic fibroblasts and the SH-SY5Y neuroblastoma cell line. We conclude that USP44 is a novel epigenetic regulator that promotes aggressive features and may be a novel target in neuroblastoma.
Implications: This study identifies a new genetic marker of aggressive neuroblastoma and identifies the mechanisms by which its overactivity contributes to the pathophysiology of this disease.
Relation Extraction in Underexplored Biomedical Domains: A Diversity-optimized Sampling and Synthetic Data Generation Approach
Authors: Delmas Maxime , Wysocka Magdalena , Freitas André 
Published: May 2024

Abstract
The sparsity of labeled data is an obstacle to the development of Relation Extraction (RE) models and the completion of databases in various biomedical areas. While being of high interest in drug-discovery, the literature on natural products, reporting the identification of potential bioactive compounds from organisms, is a concrete example of such an overlooked topic. To mark the start of this new task, we created the first curated evaluation dataset and extracted literature items from the LOTUS database to build training sets. To this end, we developed a new sampler, inspired by diversity metrics in ecology, named Greedy Maximum Entropy sampler (https://github.com/idiap/gme-sampler). The strategic optimization of both balance and diversity of the selected items in the evaluation set is important given the resource-intensive nature of manual curation. After quantifying the noise in the training set, in the form of discrepancies between the text of input abstracts and the expected output labels, we explored different strategies accordingly. Framing the task as an end-to-end Relation Extraction, we evaluated the performance of standard fine-tuning (BioGPT, GPT-2, and Seq2rel) and few-shot learning with open Large Language Models (LLMs) (LLaMA 7B-65B). In addition to their evaluation in few-shot settings, we explore the potential of open LLMs as synthetic data generators and propose a new workflow for this purpose. All evaluated models exhibited substantial improvements when fine-tuned on synthetic abstracts rather than the original noisy data. We provide our best performing (F1-score = 59.0) BioGPT-Large model for end-to-end RE of natural products relationships along with all the training and evaluation datasets. See more details at https://github.com/idiap/abroad-re.
The (Im)Possibility of Persistence? – Najm al-Dīn al-Ṭūfī’s (d. 716/1316) Atomistic Argumentation for the Probative Value of istiṣḥāb al-ḥāl
Authors: Kurnaz Serdar 
Published: May 2024

Abstract
Istiṣḥāb al-ḥāl, the presumption of the persistence of a state or ruling, is a disputed source within Islamic jurisprudence. For some scholars, it is one of the main sources of Islamic law. Many juristic principles are based on istiṣḥāb. The Hanbali scholar al-Ṭūfī (d. 716/1316) follows this idea in Sharḥ Mukhtaṣar al-Rawḍa and holds that istiṣḥāb is the fourth source of law after the Quran, Sunna, and Consensus. Al-Ṭūfī argues for the validity of istiṣḥāb with regard to a physical theory in kalām known as atomism. He discusses the possibility of continuation in existence. In his view istiṣḥāb is based on the principle that persistence/continuation (baqāʾ) is an accident (ʿaraḍ) that is not re-created in each moment in contrast to kalām atomism, which postulates that accidents are re-created constantly. This article presents al-Ṭūfī’s original approach to the validity of istiṣḥāb that guarantees the continuous existence of a state and ruling.
The impact of ciliate nutrition on aquatic ecosystems
Authors: Mandal Fatik Baran 
Published: May 2024

Abstract
Ciliate interactions including mode of nutrition contribute significantly to freshwater and marine ecosystems. Ciliates associations with their bacterial communities, and symbionts have crucial contributions to biomass productivity, transfer of nutrients to higher trophic levels and thus to sustain the ecosystems. The mixotrophic and heterotrophic ciliates are crucial in nutrient cycling by increasing nitrogen, phosphorus, and sulphur. Bacterial predator ciliates regulate the bacterial population and function as bioindicators. Endosymbionts in ciliates illustrate the incorporation of photosynthesis, nitrogen fixation and recycling, and methanogenesis, into ciliate hosts by endosymbionts. Endosymbiosis represents an evolutionary strategy of protists to acquire novel biochemical functions. Herein, I briefly give an account for the impact of ciliate nutrition on aquatic systems.
Making a Case for Trade: Shi Shipiao’s Map of the Eastern and Southern Oceans
Authors: Papelitzky Elke 
Published: May 2024

Abstract
In the early eighteenth century, the Kangxi emperor was presented with two maps in Chinese, one each from the officials Gioro Mamboo and Shi Shipiao. The maps showed southern China and Southeast Asia and were based on Dutch charts. The officials presented the maps at a time when the emperor had recently issued a law restricting Chinese trade in Southeast Asia. The map presented by Shi Shipiao adds information about sailing routes and export goods that were subject to the trade restrictions imposed by the emperor. This article argues that rather than being intended to provide a representation of seafaring knowledge, Shi aimed to use the map he presented to convince the emperor to lift the restrictions he had imposed on trade. This therefore provides an example of how maps could be used for political ends. In contrast to many other Chinese maps influenced by European sciences, these two maps show no Jesuit involvement but resemble the Selden Map as well as Japanese and Buginese charts, representing a maritime perspective in the history of knowledge exchange.
Workplace Reintegration Programs, Policies, and Procedures for Nurses Experiencing Operational Stress Injury: A Scoping Literature Review
Authors: Jones Chelsea , Vincent Michelle , O’Greysik Elly , Bright Katherine , Spencer Shaylee , Beck Amy , Gross Douglas P. , Brémault-Phillips Suzette 
Published: May 2024

Background Nurses experience elevated rates of operational stress injuries (OSIs). This can necessitate taking leave from work and subsequently engaging in a workplace reintegration process. An unsuccessful process can have long term impacts on a nurse's career, affecting the individual, their family, and broader community, while contributing to nursing shortages. A knowledge gap regarding the workplace reintegration of nurses experiencing mental health challenges, impedes the development and implementation of initiatives that might increase the success of nurses reintegrating into the workplace. This scoping review explored the existing literature concerning workplace reintegration for nurses experiencing OSIs. Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) reporting guidelines were utilized. Three key search terms across six databases were employed followed by a qualitative content analysis of the resulting literature. Results Eight documents were included. The literature exhibited high heterogeneity in objectives, content, and article types. The content analysis revealed five themes: (1) recognizing stigma, (2) elements of successful workplace reintegration, (3) considerations for military nurses, (4) considerations for nurses with substance use disorders, and (5) gaps in the existing literature. Conclusion A paucity of programs, policies, procedures, and research exists regarding workplace reintegration for nurses facing mental health challenges. It is imperative to recognize that nurses may experience OSIs, necessitating mental health support, time off work, and operationally/culturally-specific assistance in returning to work. Innovative and evidence-based approaches to workplace reintegration are needed to enhance the retention of a skilled, experienced, compassionate, and healthy nursing workforce.
Comparative Evaluation of Efficacy of Ultrasound-guided Ilioinguinal and Iliohypogasrtic Block with Conventional Technique Using PNS in Inguinal Hernia Repair
Authors: Rao Yarramsetti V. , Nadimpalli Hari Kiran , Kotturu Dathrika Vagdevi , Kasapogu Joel Ratnakar , Nimmaka Veda Sri 
Published: May 2024

Introduction: The traditional method of blocking the ilioinguinal and iliohypogastric nerves may result in drug toxicity, block failure, and a significant amount of medication. Accurate needle placement made possible by the ultrasound-guided nerve block may lower the risk of medication toxicity, overdosage, and block failure. Aim: In this study, we examined the time to rescue analgesia, drug volume needed, and onset and duration of the motor and sensory nerve block between USG and conventional methods. Settings and Design: In this prospective study, 60 male patients with inguinal hernias between the ages of 18 and 60 who were the American Society of Anesthesiology I-II members and scheduled for repair were included in the study. They were randomly divided into two groups of 30 patients each using a computerized approach. Materials and Methods: Group A patients received hernia block by the conventional method using 0.75% ropivacaine 15 ml, and Group B patients were given the block guided by ultrasound using 0.75% ropivacaine, till the nerves were surrounded on all sides by the drug. Statistical Analysis: The data were analyzed using two independent sample t-tests for demographic and hemodynamic parameters. A nonparametric test (Mann–Whitney U-test) was used to find the significance between the Visual Analog Scale. Results: There was a significantly early onset of sensory block in Group B 14.03 ± 2.82 min as compared to Group A 15.57 ± 1.52 min ( P = 0.047). The onset of motor block was also earlier in Group B 19.40 ± 2.85 min as compared to Group A 20.67 ± 1.90 min. The time to rescue analgesia was more in Group B 7.22 ± 0.97 h as compared to Group A 6.80 ± 0.70 h ( P = 0.062). The volume of drug required was less with ultrasound-guided block. Conclusions: Ultrasound-guided hernia block thus has the advantage of early onset, less dose requirement, and increase in time to rescue analgesia.
Methylene blue dose-dependently induces cutaneous inflammation and heat hyperalgesia in a novel rat model
Authors: Banik Ratan K , Sia Twan , Johns Malcolm E , Tran Phu V , Cheng Andrew Y , Setty Sudarshan , Simone Donald A 
Published: May 2024

Methylene blue (MB) has been shown to reduce mortality and morbidity in vasoplegic patients after cardiac surgery. Though MB is considered to be safe, extravasation of MB leading to cutaneous toxicity has been reported. In this study, we sought to characterize MB-induced cutaneous toxicity and investigate the underlying mechanisms. To induce MB-induced cutaneous toxicity, we injected 64 adult male Sprague-Dawley rates with 200 µL saline (vehicle) or 1%, 0.1%, or 0.01% MB in the plantar hind paws. Paw swelling, skin histologic changes, and heat and mechanical hyperalgesia were measured. Injection of 1%, but not 0.1% or 0.01% MB, produced significant paw swelling compared to saline. Injection of 1% MB produced heat hyperalgesia but not mechanical hyperalgesia. Pain behaviors were unchanged following injections of 0.1% or 0.01% MB. Global transcriptomic analysis by RNAseq identified 117 differentially expressed genes (111 upregulated, 6 downregulated). Ingenuity Pathway Analysis showed an increased quantity of leukocytes, increased lipids, and decreased apoptosis of myeloid cells and phagocytes with activation of IL-1β and Fos as the two major regulatory hubs. qPCR showed a 16-fold increase in IL-6 mRNA. Thus, using a novel rat model of MB-induced cutaneous toxicity, we show that infiltration of 1% MB into cutaneous tissue causes a dose-dependent pro-inflammatory response, highlighting potential roles of IL-6, IL-1β, and Fos. Thus, anesthesiologists should administer dilute MB intravenously through peripheral venous catheters. Higher concentrations of MB (1%) should be administered through a central venous catheter to minimize the risk of cutaneous toxicity.