bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intermolecular and Intracomplex Photoinduced Electron Transfer from Planar and Nonplanar Metalloporphyrins to p‐Quinones
Authors: Kanematsu Masanori , Naumov Panče , Kojima Takahiko , Fukuzumi Shunichi 
Published: September 2011

AbstractThe rate constants of intermolecular photoinduced electron transfer from triplet excited states of metalloporphyrins to a series of p‐benzoquinone derivatives in benzonitrile were determined to examine the effects of the driving force, the metal, and the conformational distortion of the porphyrin ring on the reorganization energies (λ) of electron transfer by laser flash photolysis. The λ values were evaluated from the determined rate constants on the basis of the Marcus theory of electron transfer. The λ values of planar metalloporphyrins, [Al(TPP)(PhCOO)] and [Zn(TPP)] (TPP2−=tetraphenylporphyrin dianion), are approximately the same, but they are 0.27 eV smaller than those of the corresponding nonplanar (saddle‐distorted) metalloporphyrins [Al(DPP)(PhCOO)] and [Zn(DPP)] (DPP2−=dodecaphenylporphyrin dianion) when they are compared for the same driving force of photoinduced electron transfer. The axial ligand PhCOO− of [Al(TPP)]+ and [Al(DPP)]+ was replaced by anthraquinone‐2‐carboxylate (AqCOO−) to afford the electron donor–acceptor complexes [Al(TPP)(AqCOO)] and [Al(DPP)(AqCOO)], respectively. The X‐ray crystal structure of [Al(TPP)(AqCOO)] revealed strong coordination of AqCOO− to the Al3+ ion of [Al(TPP)]+ and the existence of π–π interactions between AqCOO− and the porphyrin ring. In the case of the saddle‐distorted [Al(DPP)(AqCOO)], however, the AqCOO− moiety is nearly perpendicular to the porphyrin ring. The photodynamics of intracomplex photoinduced electron transfer from the singlet excited state of [Al(TPP)]+ and [Al(DPP)]+ to the AqCOO− moiety were also examined in comparison with the intermolecular photoinduced electron‐transfer reactions, and the determined rate constants were evaluated in light of the Marcus theory of electron transfer to reveal that the electron transfer is adiabatic in each case.
Synthesis, Structure, and Glutathione Peroxidase‐Like Activity of Amino Acid Containing Ebselen Analogues and Diaryl Diselenides
Authors: Selvakumar Karuthapandi , Shah Poonam , Singh Harkesh B. , Butcher Ray J. 
Published: September 2011

AbstractThe synthesis of some ebselen analogues and diaryl diselenides, which have amino acid functions as an intramolecularly coordinating group (Se⋅⋅⋅O) has been achieved by the DCC coupling procedure. The reaction of 2,2′‐diselanediylbis(5‐tert‐butylisophthalic acid) or the activated ester tetrakis(2,5‐dioxopyrrolidin‐1‐yl) 2,2′‐diselanediylbis(5‐tert‐ butylisophthalate) with different C‐protected amino acids (Gly, L‐Phe, L‐Ala, and L‐Trp) afforded the corresponding ebselen analogues. The used precursor diselenides have been found to undergo facile intramolecular cyclization during the amide bond formation reaction. In contrast, the DCC coupling of 2,2′‐diselanediyldibenzoic acid with C‐protected amino acids (Gly, L/D‐Ala and L‐Phe) affords the corresponding amide derivatives and not the ebselen analogues. Some of the representative compounds have been structurally characterized by single‐crystal X‐ray crystallography. The glutathione peroxidase (GPx)‐like activities of the ebselen analogues and the diaryl diselenides have been evaluated by using the coupled reductase assay method. Intramolecularly stabilized ebselen analogues show slightly higher maximal velocity (Vmax) than ebselen. However, they do not show any GPx‐like activity at low GSH concentrations at which ebselen and related diselenides are active. This could be attributed to the peroxide‐mediated intramolecular cyclization of the corresponding selenenyl sulfide and diaryl diselenide intermediates generated during the catalytic cycle. Interestingly, the diaryl diselenides with alanine (l,l or d,d) amide moieties showed excellent catalytic efficiency (kcat/KM) with low KM values in comparison to the other compounds.
Highly Porous, Water‐Soluble, Superparamagnetic, and Biocompatible Magnetite Nanocrystal Clusters for Targeted Drug Delivery
Authors: Dong Fuping , Guo Wanping , Bae Jae‐Ho , Kim Sun‐Hee , Ha Chang‐Sik 
Published: September 2011

AbstractMagnetic particles have become very promising materials for drug delivery. However, preparation of magnetite particles with high surface area, biocompatibility, strong magnetic response, and suitable particle size still remains a major challenge. In this report, magnetite nanocrystal clusters with high surface areas were fabricated through a solvothermal process by introducing ammonium acetate as a porogen and trisodium citrate as a surface modification agent. The porosity, which was controlled by the reactant concentration, has been investigated in detail. The surface area of the nanocrystal clusters was as high as 141 m2g−1. Ibuprofen, as a model drug, was entrapped into the magnetite carriers. The interfacial interaction between the carboxylic groups on the drug molecules and the carboxylate groups on the carriers enhanced the loading efficiency. Low cytotoxicity in MCF‐7 cell and in vitro constant drug release behavior combined with the high drug loading efficiency and high saturation magnetization values demonstrated the potential of the as‐synthesized magnetite materials in targeted drug release systems.
A Microenvironment‐Sensitive Fluorescent Pyrimidine Ribonucleoside Analogue: Synthesis, Enzymatic Incorporation, and Fluorescence Detection of a DNA Abasic Site
Authors: Tanpure Arun A. , Srivatsan Seergazhi G. 
Published: September 2011

AbstractBase‐modified fluorescent ribonucleoside‐analogue probes are valuable tools in monitoring RNA structure and function because they closely resemble the structure of natural nucleobases. Especially, 2‐aminopurine, a highly environment‐sensitive adenosine analogue, is the most extensively utilized fluorescent nucleoside analogue. However, only a few isosteric pyrimidine ribonucleoside analogues that are suitable for probing the structure and recognition properties of RNA molecules are available. Herein, we describe the synthesis and photophysical characterization of a small series of base‐modified pyrimidine ribonucleoside analogues derived from tagging indole, N‐methylindole, and benzofuran onto the 5‐position of uracil. One of the analogues, based on a 5‐(benzofuran‐2‐yl)pyrimidine core, shows emission in the visible region with a reasonable quantum yield and, importantly, displays excellent solvatochromism. The corresponding triphosphate substrate is effectively incorporated into oligoribonucleotides by T7 RNA polymerase to produce fluorescent oligoribonucleotide constructs. Steady‐state and time‐resolved spectroscopic studies with fluorescent oligoribonucleotide constructs demonstrate that the fluorescent ribonucleoside photophysically responds to subtle changes in its environment brought about by the interaction of the chromophore with neighboring bases. In particular, the emissive ribonucleoside, if incorporated into an oligoribonucleotide, positively reports the presence of a DNA abasic site with an appreciable enhancement in fluorescence intensity. The straightforward synthesis, amicability to enzymatic incorporation, and sensitivity to changes in the microenvironment highlight the potential of the benzofuran‐conjugated pyrimidine ribonucleoside as an efficient fluorescent probe to investigate nucleic acid structure, dynamics, and recognition events.
External‐Energy‐Independent Polymer Capsule Motors and Their Cooperative Behaviors
Authors: Zhao Guanjia , Seah Tzu Hui , Pumera Martin 
Published: September 2011

AbstractThe design and development of mobile nano‐, micro‐, and millimeter‐scale autonomous systems have been perused over several decades. Here, we introduce a millimeter‐sized polymer capsule motor with specific features and functionalities. It runs without any external energy sources or the consumption of external fuels such as H2O2 or glucose. The occurrence of motion is due to the asymmetric release of organic solvent from the capsule and the asymmetric change in the surface tension of the surrounding liquid. The capsule moves from a place of lower surface tension to a place of higher surface tension (Marangoni effect) in an attempt by the system to attain the desirable lowest‐free‐energy state. The operation of the motor is versatile in terms of the environment, as it moves on a wide variety of liquid/air interfaces, including water, sea water, organic solvent/water mixtures, and acids. A high‐motion velocity was observed, with a travelling distance of over 20 meters. The manipulation of its motion was achieved upon functionalization with nickel powder and application of an external magnetic field. Long‐range interaction behaviors and surface‐cleaning effects due to the chemotaxis effect were also demonstrated when the capsule was functionalized with sodium dodecyl sulfate (SDS). We believe that a plethora of applications can be envisioned with this motor, such as cargo delivery, manipulation of matter, sensing and detection, biorecognition, and environmental remediation.
Methanesulfonates of High‐Valent Metals: Syntheses and Structural Features of MoO2(CH3SO3)2, UO2(CH3SO3)2, ReO3(CH3SO3), VO(CH3SO3)2, and V2O3(CH3SO3)4 and Their Thermal Decomposition under N2 and O2 Atmosphere
Authors: Betke Ulf , Neuschulz Kai , Wickleder Mathias S. 
Published: September 2011

AbstractOxide methanesulfonates of Mo, U, Re, and V have been prepared by reaction of MoO3, UO2(CH3COO)2⋅2 H2O, Re2O7(H2O)2, and V2O5 with CH3SO3H or mixtures thereof with its anhydride. These compounds are the first examples of solvent‐free oxide methanesulfonates of these elements. MoO2(CH3SO3)2 (Pbca, a=1487.05(4), b=752.55(2), c=1549.61(5) pm, V=1.73414(9) nm3, Z=8) contains [MoO2] moieties connected by [CH3SO3] ions to form layers parallel to (100). UO2(CH3SO3)2 (P21/c, a=1320.4(1), b=1014.41(6), c=1533.7(1) pm, β=112.80(1)°, V=1.8937(3) nm3, Z=8) consists of linear UO22+ ions coordinated by five [CH3SO3] ions, forming a layer structure. VO(CH3SO3)2 (P21/c, a=1136.5(1), b=869.87(7), c=915.5(1) pm, β=113.66(1)°, V=0.8290(2) nm3, Z=4) contains [VO] units connected by methanesulfonate anions to form corrugated layers parallel to (100). In ReO3(CH3SO3) (${P\bar 1}$, a=574.0(1), b=1279.6(3), c=1641.9(3) pm, α=102.08(2), β=96.11(2), γ=99.04(2)°, V=1.1523(4) nm3, Z=8) a chain structure exhibiting infinite O[ReO2]O[ReO2]O chains is formed. Each [ReO2]O[ReO2] unit is coordinated by two bidentate [CH3SO3] ions. V2O3(CH3SO3)4 (I2/a, a=1645.2(3), b=583.1(1), c=1670.2(3) pm, β=102.58(3), V=1.5637(5) pm3, Z=4) adopts a chain structure, too, but contains discrete [VO]O[VO] moieties, each coordinated by two bidentate [CH3SO3] ligands. Additional methanesulfonate ions connect the [V2O3] groups along [001]. Thermal decomposition of the compounds was monitored under N2 and O2 atmosphere by thermogravimetric/differential thermal analysis and XRD measurements. Under N2 the decomposition proceeds with reduction of the metal leading to the oxides MoO2, U3O7, V4O7, and VO2; for MoO2(CH3SO3)2, a small amount of MoS2 is formed. If the thermal decomposition is carried out in a atmosphere of O2 the oxides MoO3 and V2O5 are formed.
ChemInform Abstract: Dielectric Properties of Iron Doped Calcium Copper Titanate, CaCu2.9Fe0.1Ti4O12.
Authors: Rai Alok Kumar , Singh Nitish Kumar , Lee Sang‐Kwon , Mandal K. D. , Kumar D. , Parkash Om 
Published: September 2011

AbstractThe title compound is prepared by evaporation of a stoichiometric solution of Ca(NO3)2, Cu(NO3)2, Fe(NO3)3, TiO2, and citric acid at 70—80 °C, followed by calcination of the obtained gel in air (800 and 900 °C, 6 h each).
ChemInform Abstract: Prediction of Formation of Cubic Boron Nitride by Construction of Temperature—Pressure Phase Diagram at the Nanoscale.
Authors: Hu Shengliang , Yang Jinlong , Liu Wei , Dong Yingge , Cao Shirui , Liu Jun 
Published: September 2011

AbstractThe size‐dependent temperature—pressure phase diagram of BN is constructed on the basis of nanothermodynamic theory.
ChemInform Abstract: Preculiarities of Component Interaction in {Gd, Er}—V—Sn Ternary Systems at 870 K and Crystal Structure of RV6Sn6 Stannides.
Authors: Romaka L. , Stadnyk Yu. , Romaka V. V. , Demchenko P. , Stadnyshyn M. , Konyk M. 
Published: September 2011

AbstractPhase equilibria in the title systems are studied at 870 K by powder XRD and SEM.
ChemInform Abstract: Photocatalytic Properties of KBiO3 and LiBiO3 with Tunnel Structures.
Authors: Ramachandran Rajalakshmi , Sathiya M. , Ramesha K. , Prakash A. S. , Madras Giridhar , Shukla A. K. 
Published: September 2011

AbstractKBiO3 is synthesized by oxidation of Bi2O3 with Br2 in 50% aq.
ChemInform Abstract: New Members of Ternary Rare‐Earth Metal Boride Carbides Containing Finite Boron—Carbon Chains: Ln25B14C26 (Ln: Pr, Nd) and Nd25B12C28.
Authors: Babizhetskyy Volodymyr , Mattausch Hansjuergen , Simon Arndt , Gautier Regis , Halet Jean‐Francois 
Published: September 2011

AbstractThe title compounds are prepared by co‐melting the elements followed by heating under Ar for 24 h at 1350, 1670, and 1550 K for Pr25B14C26, Nd25B14C26, and Nd25B12C28, respectively, and annealing at 1200 K for one month.
ChemInform Abstract: NdHO, a Novel Oxyhydride.
Authors: Wideroee Marius , Fjellvaag Helmer , Norby Truls , Poulsen Finn Willy , Berg Rolf Willestofte 
Published: September 2011

AbstractNdHO is synthesized by solid state reaction of CaH2 or NdH3 and Nd2O3 (Ar/7% H2, 650 °C, 20 h) and characterized by neutron powder diffraction and Raman spectroscopy.
ChemInform Abstract: The Crystal Chemistry of Four Thorium Sulfates.
Authors: Albrecht Amanda J. , Sigmon Ginger E. , Moore‐Shay Laura , Wei Rebecca , Dawes Colleen , Szymanowski Jennifer , Burns Peter C. 
Published: September 2011

AbstractSingle crystal XRD shows that (II) crystallizes in the space group P21/m with Z = 2, (IV) in the space group Pna21 with Z = 4, (V) in the space group C2/c with Z = 4, and (VI) in the space group Pnma with Z = 4.
ChemInform Abstract: Preparation of a New Pyrochlore‐Type Compound Na0.32Bi1.68Ti2O6.46 (OH)0.44 by Hydrothermal Reaction.
Authors: Dong Qiang , Jiang Hong , Kumada Nobuhiro , Yonesaki Yoshinori , Takei Takahiro , Kinomura Nobukazu 
Published: September 2011

AbstractThe title compound is hydrothermally synthesized from a mixture of TiO2 (anatase), Bi2O3, and NaOH in the molar ratio of Na:Bi:Ti = 2:0.5:1 (H2O, 240 °C, autoclave, 48 h).
ChemInform Abstract: The —NH—(C=)—Br Functionality of Heteroaromatic Compounds as a Synthon for Fused Dihydrooxazoles.
Authors: Cegla Marek T. , Baran Marzena , Czarny Agnieszka , Zylewski Marek , Potaczek Joanna , Klenc Jeff , Strekowski Lucjan 
Published: September 2011

AbstractThe compounds (III) and (V) are stable dihydrooxazoles, whereas the reaction of the compound (VI) leads to an unstable dihydrooxazole, which undergoes rearrangement to the compound (VII).
ChemInform Abstract: Asymmetric Transfer Hydrogenation of Aromatic Ketones Using Rhodium Complexes of Chiral N‐Heterocyclic Carbenes Derived from (S)‐Pyroglutamic Acid.
Authors: Aupoix Audrey , Bournaud Chloee , Vo‐Thanh Giang 
Published: September 2011

AbstractModerate to good enantioselectivities (up to 80% e.e.) are achieved in the transfer hydrogenation of aromatic ketones (I) in iPrOH in the presence of an in situ generated chiral pyrrolidinylmethylimidazolylidene—Rh(I) catalyst.
ChemInform Abstract: Diastereoselectively Switchable Enantioselective Trapping of Carbamate Ammonium Ylides with Imines.
Authors: Jiang Jun , Xu Hua‐Dong , Xi Jian‐Bei , Ren Bai‐Yan , Lv Feng‐Ping , Guo Xin , Jiang Li‐Qin , Zhang Zhi‐Yong , Hu Wen‐Hao 
Published: September 2011

AbstractThree‐component Mannich‐type reaction of diazoacetates (I) and (VI) with carbamate (III) and imines (II) and (VII) in the presence of a chiral phosphoric acid—Rh catalyst provides access towards enantioenriched α‐substituted α,β‐diamino acid derivatives.
ChemInform Abstract: Asymmetric Hydrocyanation of α,β‐Unsaturated Ketones into β‐Cyano Ketones with the [Ru(phgly)2(binap)]/C6H5OLi Catalyst System.
Authors: Kurono Nobuhito , Nii Noriyuki , Sakaguchi Yusuke , Uemura Masato , Ohkuma Takeshi 
Published: September 2011

AbstractAn efficient asymmetric conjugate addition of in situ generated HCN towards α,β‐unsaturated ketones is presented.
ChemInform Abstract: An Efficient Multicomponent Stereoselective Synthesis of 1,2,4‐Trisubstituted 1,3‐Thiazetidines.
Authors: Rai Ankita , Yadav Lal Dhar S. 
Published: September 2011

AbstractThe process affords the pharmaceutically important ring system with excellent cis‐selectivity (<90% d.e.
ChemInform Abstract: Solvent Controlled Mechanistic Dichotomy in a Au(III)‐Catalyzed, Heterocyclization Triggered, Nazarov Reaction.
Authors: Krafft Marie E. , Vidhani Dinesh V. , Cran John W. , Manoharan Mariappan 
Published: September 2011

AbstractA variety of cyclopentafurans (VII) is readily prepared by gold‐catalyzed heterocyclization/Nazarov cyclization.
ChemInform Abstract: Palladium‐Catalyzed Stereoselective Synthesis of 3‐(Aminomethylene)‐oxindoles.
Authors: Bararjanian Morteza , Hosseinzadeh Saeedeh , Balalaie Saeed , Bijanzadeh Hamid Reza , Wolf Eckardt 
Published: September 2011

AbstractUgi four‐component reaction and direct carbopalladative cyclization—Buchwald reaction sequence permits a convenient synthesis of the title compounds.
ChemInform Abstract: Direct Annulation and Alkylation of Indoles with 2‐Aminobenzyl Alcohols Catalyzed by TFA.
Authors: Robertson Forest J. , Kenimer Bradshaw D. , Wu Jimmy 
Published: September 2011

AbstractA simple procedure is developed for the direct preparation of 5,6‐fused indoline aminals (III) and (V) from 3‐substituted indoles as subunits of alkaloids.
ChemInform Abstract: Ammonium Metavanadate as an Efficient Catalyst for the Synthesis of 2,4,5‐Triaryl‐1H‐imidazoles.
Authors: Niralwad Kirti S. , Shingate Bapurao B. , Shingare Murlidhar S. 
Published: September 2011

AbstractThe title compounds (III) and (V) are synthesized in an one‐pot three component condensation by using an inexpensive, mild, recoverable, and reusable catalyst.
ChemInform Abstract: Diastereoselective Synthesis of Functionalized 2‐Methyltetrahydropyran‐4‐ones.
Authors: Clarke Paul A. , Sellars Philip B. , Mistry Nimesh 
Published: September 2011

AbstractA modified Maitland—Japp reaction using acetamide derivative (II) instead of an aldehyde produces dihydropyranones, which can be diastereoselectively reduced to the corresponding 2,6‐cis‐isomers.
ChemInform Abstract: 1,3,5‐Trichloro‐2,4,6‐triazinetrion: A Versatile Heterocycle for the One‐Pot Synthesis of 14‐Aryl‐ or Alkyl‐14H‐dibenzo[a,j]xanthene, 1,8‐Dioxooctahydroxanthene and 12‐Aryl‐8,9,10,12‐tetrahydrobenzo[a]xanthene‐11‐one Derivatives under Solvent‐Free Conditions.
Authors: Maleki Behrooz , Gholizadeh Mostafa , Sepehr Zeinalabedin 
Published: September 2011

AbstractA facile, clean, green, efficient, and environmentally friendly protocol for the synthesis of the title compounds (III), (V), (VI), and (VIII) is presented.
ChemInform Abstract: Synthesis of New Vinylpyridium Salts.
Authors: Posada Paloma , Brana Miguel F. , Villarino Antonio L. , Dominguez Vicente , Ortuno Ismael , Martinez Carmen 
Published: September 2011

AbstractBase‐catalyzed reaction of pyridinium salts (I) with aryl aldehydes results in the formation of both condensation (III) and dimerization products (IV), in general.
ChemInform Abstract: (.+‐.)‐2‐Aryl‐2,3‐dihydro‐4(1H)‐quinolinones by a Tandem Reduction—Michael Addition Reaction.
Authors: Bunce Richard A. , Nammalwar Baskar 
Published: September 2011

Abstract2,3‐Dihydro‐4(1H)‐quinolinone derivatives of type (V) and (IX) are prepared via reductive cyclization of o‐nitrophenylpropenone (IV) or related 2‐nitrochalcone derivatives (VIII) using Fe‐powder in conc.
ChemInform Abstract: Synthesis of β‐ and γ‐Carbolines via Ruthenium and Rhodium Catalyzed [2 + 2 + 2] Cycloadditions of Yne‐Ynamides with Methylcyanoformate.
Authors: Nissen Felix , Richard Vincent , Alayrac Carole , Witulski Bernhard 
Published: September 2011

AbstractThe direction of the [2 + 2 + 2] cycloaddition of yne‐ynamides with methyl cyanoformate leading to β‐ and/or γ‐carbolines depends on the structure of the yne‐ynamide and the type of catalyst used.
ChemInform Abstract: (Z)‐(2‐Bromovinyl)‐MIDA Boronate: A Readily Accessible and Highly Versatile Building Block for Small Molecule Synthesis.
Authors: Woerly Eric M. , Struble Justin R. , Palyam Nagarjuna , O'Hara Sean P. , Burke Martin D. 
Published: September 2011

AbstractThe synthesis of the bifunctional (Z)‐olefin building block (II) is developed and the utility the product in a variety of Pd‐catalyzed cross‐coupling reactions is demonstrated.
ChemInform Abstract: Chalcogen‐Containing Heterocycles. Part 34. Tandem Addition—Cyclization of o‐Ethynylphenyllithiums and Isoselenocyanates: A Covenient Preparation of Functionalized Benzo[c]selenophenes.
Authors: Kaname Mamoru , Sashida Haruki 
Published: September 2011

AbstractThe process is extended to the iodo derivative (VII), which is amenable to Pd‐catalyzed cross‐coupling reactions.
ChemInform Abstract: First Total Synthesis of Tenuifolin via PIFA‐Mediated Oxidative Biaryl Coupling.
Authors: Tang Changhua , Li Ziyuan , Wang Yiyun , Xu Jinyi , Kong Lingyi , Yao Hequan , Wu Xiaoming 
Published: September 2011

AbstractDifferent strategies to synthesize the olefin precursor mixture (II) are investigated.
ChemInform Abstract: Halichonadins G—J; New Sesquiterpenoids from a Sponge Halichondria sp.
Authors: Suto Shohei , Tanaka Naonobu , Fromont Jane , Kobayashi Jun'ichi 
Published: September 2011

AbstractHalichonadin G (Ia) and I (II) are found to exhibit cytotoxicity, whereas H (Ib) and J (III) are inactive.
ChemInform Abstract: Steroids from the South China Sea Gorgonian Coral Muricella flexuosa
Authors: Wang Ping , Qi Shu‐Hua , Liu Kai‐Sheng , Huang Li‐Si , He Fei , Wang Yi‐Fei 
Published: September 2011

Abstractisolation, structure determination and cytotoxicity of four new steroidal glycosides, muricellasteroids A—D (I), and related muricellasteroid E (II)
ChemInform Abstract: Inhibition of Invasion and Capillary‐Like Tube Formation by Retrohydroxamate‐Based MMP Inhibitors.
Authors: Lee Seung‐Taek , et al. et al. 
Published: September 2011

AbstractCompounds (Ic) and (Id) inhibit effectively chemo‐invasion of HT‐1080 cells and tube formation of HUVECs.
ChemInform Abstract: Synthesis and Importance of Bulky Aromatic Cap of Novel SAHA Analogues for HDAC Inhibition and Anticancer Activity.
Authors: Chun Pusoon , Kim Won Hee , Kim Jungsu , Kang Jin‐Ah , Lee Hye Jin , Park Ji Young , Ahn Mee Young , Kim Hyung Sik , Moon Hyung Ryong 
Published: September 2011

AbstractCompounds (Ib)—(Id) exhibit a higher inhibitory activity on total HDACs, HDAC1, HDAC2, and HDAC7 and higher anticancer activity against MCF‐7, MDA‐MB‐231, MCF‐7/Dox, MCF‐7/Tam, SK‐OV‐3, LNCaP, and PC3 human cancer cell lines than SAHA.
Application of Metrics in Early Stages of Process Development – Two Case Studies
Authors: Eissen Marco , Brinkmann Tobias , Klein Mieke , Schwartze Britta , Weiß Markus 
Published: September 2011

AbstractZur Entwicklung nachhaltiger Prozesse ist es schon in frühen Phasen der Entwicklung sinnvoll, Methoden aus dem Bereich des betrieblichen Umwelt‐, Gesundheits‐ und Sicherheits‐Management (EHS‐Management) als auch aus dem Ökobilanzsektor zu nutzen. Vor dem Hintergrund einer geringen Datenverfügbarkeit und Datenqualität werden Möglichkeiten der Anwendung von Kennzahlen in den frühen Phasen der Prozessentwicklung an zwei Fallbeispielen vorgestellt. Zum einen wird eine vergleichende Stoffstromanalyse von zwei alternativen Syntheserouten zur Herstellung einer enantiomerenreinen β‐Aminosäure zur Bewertung von Gesundheits‐ und Kostenaspekten diskutiert. Zum anderen wird am Beispiel der Glutaraldehyd‐Produktion die Berechnung des kumulierten Energieaufwands mithilfe von Software‐Tools gezeigt.