bluuebunny/crossref_metadata_2025_split huggingface dataset:
F.M. Dostoevsky’s Nationalism: History, Historiography, and Politics. An Old Controversy in a Post-2022 Context
Authors: Berest Julia 
Published: May 2024

Abstract
Dostoevsky’s nationalism has long been a sensitive and controversial topic in Western scholarship. At the core of the controversy is the problem of explaining the stark contrast between Dostoevsky’s philosophical message of universal love and the explicitly xenophobic, chauvinistic and war-glorifying statements found in many of his journalistic articles. Russia’s full-scale war in Ukraine has reignited the old controversy in ways that have brought to light the profound political implications involved in interpreting Russian history in a post-2022 context. Many Ukrainian intellectuals and public figures have come to question not only the appropriateness of Dostoevsky’s title as a “great humanist” but also the conventions of Dostoevsky’s reception in Western scholarship, which serve to maintain this image of the writer in the public mind, despite many of his unpalatable ideas. These sentiments are echoed by (as yet) a small group of Russianists in the West who argue for the need to reconsider Dostoevsky from a more critical, decolonizing perspective. This essay offers a historiographic review of the theme of Dostoevsky’s nationalism in Western and Russian scholarship over the past two decades. It also highlights the way in which Dostoevsky’s nationalist ideas have been used by Russian propagandists in popular media since Russia’s first invasion of Ukraine in 2014.
The 19th Century Origins of Russia’s Fixation on Ukraine: Strengthening Global Influence and Securing Domestic Stability
Authors: Perekhoda Hanna 
Published: May 2024

Abstract
The present article aims to propose a theoretical framework capable of elucidating the intriguing resilience of the ideas shaping the attitudes of Russian ruling circles and intellectuals toward Ukraine. Offering a perspective that incorporates the latest findings on Russia’s “empire-nation dilemma” into the explanatory model, it delves into the historical context in which the Russian political and intellectual elite’s worldview and self-narratives were shaped – the period spanning from the 1830s to 1917. It reveals the intricate link between their sense of ontological (in-)security in relation to the West and the belief that assimilating Ukraine was pivotal for bolstering external power and ensuring internal stability within the Russian state.
Muscovite Claims to Rus Lands (1377–1700)
Authors: Velychenko Stephen 
Published: May 2024

Abstract
Muscovite princes like other medieval princes used the past to legitimize their policies. Their chroniclers traced Muscovy’s origins to the once metropole Kyiv according to the medieval logic of translatio imperii. After 1800, unlike their European counterparts, Russian historians did not dispense with medieval stories finally formulated by the mid 1500s, about their country. They still linked Moscow to Kyiv repeating an inherited tale about a supposed origins of “Russian history” to a non-Russian territory incorporated into their empire only in the late eighteenth century. They failed to separate the national from the imperial in their grand narrative of Russian history. This article reviews the evolution of Muscovites’ understanding of relations between Muscovy and Rus lands it did not control that historians of imperial Russia then adopted, rather than abandoned.
Pengaruh Manajemen Keluarga, Struktur Kepemilikan Keluarga, Struktur Modal dan Invesment Opportunity Set (IOS) Terhadap Kinerja Perusahaan (Studi pada Perusahaan Manufaktur yang Terdaftar di Bursa Efek Indonesia Periode 2017-2022)
Authors: Jabar Muhammad Abdul , Kufepaksi Mahatma , Dalimunthe Nindytia Puspitasari 
Published: May 2024

A family company or family business is a business in which two or more family members are directly involved to have ownership and become the main control of the business. The study examined the effect of family management, family ownership structure, capital structure and investment opportunity set on company performance. The population of this study is manufacturing companies listed on the Indonesia Stock Exchange from 2017 to 2022 and a sample of 22 companies using purposive sampling techniques. By using multiple linear regression for panel data and using data processing software in the form of Eviews, this study found that family management and family ownership structure did not affect company performance, capital structure had a negative and significant effect on company performance and investment opportunity set had a positive and significant effect on company performance.
THE POTENTIALS AND CHALLENGES OF MOBILE-ASSISTED LANGUAGE LEARNING (MALL) FOR EFL/ESL LEARNERS
Authors: Sanjaya Eko 
Published: May 2024

Mobile-assisted Language Learning (MALL) studies have indicated promising potentials for English language learning enhancement. However, since the implementation of MALL can be viewed as the process of transition from physical learning to e-learning, the implementation has also faced challenges in real practices. Thus, this study aims to review the opportunities and challenges that have been experienced by EFL/ESL learners in the implementation of MALL. Using descriptive qualitative method, the study was done by employing library research to collect the data. The study reviewed 30 publications in the MALL implementation area. The data were analyzed based on the reported potentials and challenges in the MALL implementation. They were then categorized into the subthemes describe the potentials and challenges. The findings showed a variety of benefits and issues in MALL implementation.
Identification of Cinnamein, a Component of Balsam of Tolu/Peru, as a New Ligand of PPARα for Plaque Reduction and Memory Protection in a Mouse Model of Alzheimer’s Disease
Authors: McKay Mary , Gorai Sukhamoy , Paidi Ramesh K. , Mondal Susanta , Pahan Kalipada 
Published: May 2024

Background: Despite intense investigations, no effective treatment is yet available to reduce plaques and protect memory and learning in patients with Alzheimer’s disease (AD), the most common neurodegenerative disorder. Therefore, it is important to identify a non-toxic, but effective, treatment option for AD. Objective: Cinnamein, a nontoxic compound, is naturally available in Balsam of Peru and Tolu Balsam. We examined whether cinnamein treatment could decrease plaques and improve cognitive functions in 5XFAD mouse model of AD. Methods: We employed in silico analysis, time-resolved fluorescence energy transfer assay, thermal shift assay, primary neuron isolation, western blot, immunostaining, immunohistochemistry, Barnes maze, T maze, and open field behavior. Results: Oral administration of cinnamein led to significant reduction in amyloid-β plaque deposits in the brain and protection of spatial learning and memory in 5XFAD mice. Peroxisome proliferator-activated receptor alpha (PPARα), a nuclear hormone receptor, is involved in plaque lowering and increase in hippocampal plasticity. While investigating underlying mechanisms, we found that cinnamein served as a ligand of PPARα. Accordingly, oral cinnamein upregulated the level of PPARα, but not PPARβ, in the hippocampus, and remained unable to decrease plaques from the hippocampus and improve memory and learning in 5XFAD mice lacking PPARα. While A disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) is one of the drivers of nonamyloidogenic pathway, transcription factor EB (TFEB) is considered as the master regulator of autophagy. Cinnamein treatment was found to upregulate both ADAM10 and TFEB in the brain of 5XFAD mice via PPARα. Conclusions: Our results suggest that this balsam component may have therapeutic importance in AD.
A Scoping Review of Alzheimers Disease Hypotheses: An Array of Uni- and Multi-Factorial Theories
Authors: Duchesne Simon , Rousseau Louis-Simon , Belzile-Marsolais Florence , Welch Laurie-Ann , Cournoyer Béatrice , Arseneau Marianne , Lapierre Véronick , Poulin Sara-Maude , Potvin Olivier , Hudon Carol 
Published: May 2024

Background: There is a common agreement that Alzheimers disease (AD) is inherently complex; otherwise, a general disagreement remains on its etiological underpinning, with numerous alternative hypotheses having been proposed. Objective: To perform a scoping review of original manuscripts describing hypotheses and theories of AD published in the past decades. Results: We reviewed 131 original manuscripts that fulfilled our inclusion criteria out of more than 13,807 references extracted from open databases. Each entry was characterized as having a single or multifactorial focus and assigned to one of 15 theoretical groupings. Impact was tracked using open citation tools. Results: Three stages can be discerned in terms of hypotheses generation, with three quarter of studies proposing a hypothesis characterized as being single-focus. The most important theoretical groupings were the Amyloid group, followed by Metabolism and Mitochondrial dysfunction, then Infections and Cerebrovascular. Lately, evidence towards Genetics and especially Gut/Brain interactions came to the fore. Conclusions: When viewed together, these multi-faceted reports reinforce the notion that AD affects multiple sub-cellular, cellular, anatomical, and physiological systems at the same time but at varying degree between individuals. The challenge of providing a comprehensive view of all systems and their interactions remains, alongside ways to manage this inherent complexity.
Prevalence of Mild Cognitive Impairment and Alzheimer’s Disease Identified in Veterans in the United States
Authors: Aguilar Byron J. , Jasuja Guneet K. , Li Xuyang , Shishova Ekaterina , Palacios Natalia , Berlowitz Dan , Morin Peter , O’Connor Maureen K. , Nguyen Andrew , Reisman Joel , Leng Yue , Zhang Raymond , Monfared Amir Abbas Tahami , Zhang Quanwu , Xia Weiming 
Published: May 2024

Background: Diagnostic codes can be instrumental for case identification in Alzheimer’s disease (AD) research; however, this method has known limitations and cannot distinguish between disease stages. Clinical notes may offer more detailed information including AD severity and can complement diagnostic codes for case identification. Objective: To estimate prevalence of mild cognitive impairment (MCI) and AD using diagnostics codes and clinical notes available in the electronic healthcare record (EHR). Methods: This was a retrospective study in the Veterans Affairs Healthcare System (VAHS). Health records from Veterans aged 65 years or older were reviewed during Fiscal Years (FY) 2010–2019. Overall, 274,736 and 469,569 Veterans were identified based on a rule-based algorithm as having at least one clinical note for MCI and AD, respectively; 201,211 and 149,779 Veterans had a diagnostic code for MCI and AD, respectively. During FY 2011–2018, likely MCI or AD diagnosis was defined by≥2 qualifiers (i.e., notes and/or codes)≥30 days apart. Veterans with only 1 qualifier were considered as suspected MCI/AD. Results: Over the 8-year study, 147,106 and 207,225 Veterans had likely MCI and AD, respectively. From 2011 to 2018, yearly MCI prevalence increased from 0.9% to 2.2%; yearly AD prevalence slightly decreased from 2.4% to 2.1%; mild AD changed from 22.9% to 26.8%, moderate AD changed from 26.5% to 29.1%, and severe AD changed from 24.6% to 30.7% Conclusions: The relative distribution of AD severities was stable over time. Accurate prevalence estimation is critical for healthcare resource allocation and facilitating patients receiving innovative medicines.
Maternal and neonatal outcomes associated with illness severity of maternal COVID-19
Authors: Sisman J. , Adhikari E.H. , Black L.F. , Weiss A. , Brown L.S. , Brion L.P. 
Published: May 2024

BACKGROUND: Several reports demonstrated that perinatal SARS-CoV-2 has significant impact on maternal and neonatal health outcomes. However, the relationship between severity of maternal illness with outcomes remains less clear. METHODS: This is a single-center retrospective cohort study of mother/infant dyads with positive maternal test for SARS-CoV-2 between 14 days prior and 3 days after delivery from 3/30/2020 to 12/28/2021. RESULTS: Among 538 mothers, those with moderate/severe/critical illness were more likely to undergo induction, receive oxygen, mechanical ventilation or ECMO. Mortality was significantly higher among the mothers with severe illness than asymptomatic and those with mild illness (6% vs 0% and 0%, respectively, P < 0.05). Neonates born to mothers with moderate/severe/critical illness were more likely to be preterm with lower birth weight, and to be admitted to the NICU ( P < 0.05) but not to be small for gestational age. Mild maternal illness was only associated with NICU admission for isolation precaution and decreased rate of breastfeeding. CONCLUSIONS: Maternal illness severity was significantly associated with prematurity and several adverse maternal and neonatal outcomes.
Outdated latin names of medicinal plants in the monographs of the State Pharmacopoeia of the Russian Federation, XIV edition (review)
Authors: Povydysh M. N. , Goncharov M. Yu. 
Published: May 2024

Introduction. The State Pharmacopoeia of the Russian Federation, XIV-th edition (SP XIV), includes 107 monographs devoted to medicinal plant materials. The purpose of the study was to identify incorrect Latin names of medicinal plants in the monographs of the XIV edition, study the officially accepted Latin names and taxonomic position of medicinal plants in accordance with the contemporary system of flowering plants, and justify the need to make changes in subsequent editions of the pharmacopoeia.Text. 44 cases of incorrect Latin names were found. This is explained by the fact that when developing new pharmacopoeia monographs, either Latin names historically established in Russian pharmacognosy were used, or names that were legal at the time of the last edition of the Pharmacopoeia. The bulk of nomenclatural changes are associated with the adoption of the new APG system of flowering plants, based on molecular genetic data. The paper contains lists of plants for which the State Pharmacopoeia XIV contains an incorrect name of the genus, species, family or author, indicating the correct name, as well as comments on the rules of modern botanical nomenclature.Conclusion. In connection with the prospects for processing monographs on medicinal plant raw materials for the State Pharmacopoeia XV-th edition, as well as the EAEU Pharmacopoeia, the harmonization of the nomenclature of pharmacopoeial plants with modern international requirements becomes especially relevant.
Algorithm for the development of a multicomponent pharmaceutical substance of plant origin with antimicrobial action: from science search to dosage form
Authors: Filatov V. A. , Kulyak O. Yu. , Kalenikova E. I. 
Published: May 2024

Introduction. Despite the proven clinical efficacy of antifungal and anti-inflammatory drugs for the prevention and treatment of seborrheic dermatitis, the search for new targets and the development of new substances with a beneficial effect on the scalp microflora, with a low risk of antimicrobial resistance and adverse effects, are relevant.Aim. Development of the antimicrobial multicomponent pharmaceutical substance of plant origin in stages: from a literature search for promising substances, analysis of their composition by GC-MS, in silico evaluation of the affinity of individual components to pathogenetic targets, selection of the optimal composition of a multicomponent substance based on the results of in vitro research of antimicrobial action and the making of a medical dosage form based on it – a medicinal shampoo for the treatment of seborrheic dermatitis.Materials and methods. Objects of research: tea tree essential oil, 1,8-cineole, α-(-)-bisabolol and the multicomponent substance based on them. Methods: molecular docking (AutoDock version 4.2), prediction of pharmacological activity (Phyto4Health), TLC, GC-MS, study of antimicrobial activity in vitro.Results and discussion. Based on the results of a literature search, 3 promising substances were selected for the development of a multicomponent plant-based substance: tea tree essential oil, 1,8-cineole and α-(-)-bisabolol. Molecular docking predicted the targeted activity of the phytochemicals of tea tree essential oil, 1,8-cineole and α-(-)-bisabolol on the domains of ABC-transporters of microorganisms involved in the pathogenesis of seborrheic dermatitis and justified the possibility of use for therapy. The multicomponent substance has been developed based on tea tree essential oil, 1,8-cineole and α-(-)-bisabolol in a mass ratio of 1 : 1 : 1. The qualitative composition of the substance was assessed by TLC and GC-MS methods, and 15 terpenes were quantitatively identified in its composition with a predominance of terpinen-4-ol (16.98 %), 1,8-cineole (25.63 %) and α-(-)-bisabolol (27.67 %). The synergistic antimicrobial activity of the substance has been established against S. epidermidis, S. aureus, C. albicans and M. furfur in comparison with benzalkonium chloride, ketoconazole and climbazole. The composition of a new medical shampoo based on the investigated substance has been developed, which has a pronounced antifungal effect (more than 99.0 %) against M. furfur without visible suppression of normal microflora. For the novel substance of plant origin and medical shampoo, quality parameters were assessed in accordance with the Russian Pharmacopoeia of XIV edition.Conclusion. A substance of plant origin with synergistic and targeted antimicrobial activity has been developed. It has an interest for further study as a drug and API for new products for the treatment of seborrheic dermatitis.
Challenging of ECMO application in pediatric restrictive cardiomyopathy: case report of a novel TNNI3 variant
Authors: Jin Yuxi , Xu Juan , Hua Yimin , Zhang Haiyang , Li Yifei 
Published: May 2024

BackgroundRestrictive cardiomyopathy (RCM) represents a rare cardiovascular disorder stemming from filament-associated genes. Nonetheless, treating RCM presents considerable challenges, particularly concerning device implantation and mechanical support. Furthermore, elucidating the molecular function of specific variants holds promise in benefiting patients and enhancing prognosis, given the significant heterogeneity among RCM variants.Case presentationThe proband, an eight-year-old female, was admitted to our hospital post cardiopulmonary resuscitation due to sudden cardiac arrest. Echocardiography revealed bilateral atrial enlargement. Whole-exome sequencing uncovered a novel heterozygous mutation (c.509G&gt;A, p.R170Q) in TNNI3. Evaluation using the MutationTaster application deemed c.509G&gt;A pathogenic (probability = 0.99). Following clinical manifestations, imaging assessments, and genetic screening, the proband received an RCM diagnosis. ECMO was recommended along with continuous renal replacement therapy. However, persistent atrial flutter ensued post-ECMO withdrawal. Attempts to restore cardiac rhythm with cardioversion, metoprolol, and amiodarone proved futile. Subsequent heart failure led to the patient's demise due to cardiac shock. Based on crystal protein structural analysis, we observed that cTnI-R170Q and R170W exerted similar impacts on protein structural stability and formation. However, both differed significantly from cTnI-R170G, primarily influencing amino acid regions 32–79 and 129–149, involved in TnC and actin binding. Therefore, cTnI-R170Q was revealed to induce RCM via the same molecular mechanism as cTnI-R170W.ConclusionManaging RCM remains a critical challenge. This study underscores the discouragement of device implantations for cardiac pump functional support in RCM, particularly for non-short-term scheduled HTx. Additionally, considering catheter ablation for atrial fibrosis-induced AFs is recommended. Mechanistically, cTnI-R170Q primarily diminishes troponin-actin interactions and destabilizes thin filaments.
Adaptation of the internet business self-efficacy scale for Peruvian students with a commercial profile
Authors: Torres-Miranda Julio Samuel , Ccama Celinda Aroni , Niño Valiente Juana Rosa , Turpo-Chaparro Josué Edison , Castillo-Blanco Ronald , Mamani-Benito Oscar 
Published: May 2024

IntroductionGiven the lack of instruments to evaluate the sense of efficacy regarding entrepreneurial capacity in Peruvian university students, this study aims to translate into Spanish, adapt, and validate the Internet Entrepreneurial Self-efficacy Scale in Peruvian university students with a commercial profile.MethodAn instrumental study was conducted where 743 students between 18 and 42 years old participated in careers with a commercial profile (Administration, Accounting, Economics, and other related careers) from the three regions of Peru (Coast, Mountains, Jungle). For analyzing content-based validity, Aiken’s V coefficient was used, Cronbach’s Alpha coefficient was used for reliability, and internal structure was used through confirmatory factor analysis.ResultsA reverse translation was achieved in the appropriate time and context. All items proved to be valid (V &gt;0.70), and the reliability of the instrument was very good (α = 0.96). Concerning the results of the confirmatory factor analysis, the three-dimensional structure of the instrument was evaluated, finding an adequate fit [χ2(87) = 279.6, p &lt; 0.001, CFI = 0.972, RMSEA = 0.049, SRMR = 0.025], based on this, the original internal structure was corroborated. In complementary analyses, it was found that the instrument is invariant according to sex and university. Finally, it demonstrates significant correlations with scales that measure similar constructs.ConclusionThe Entrepreneurial Self-efficacy Scale on the Internet shows adequate psychometric properties; therefore, it can be used as a management tool to analyze the entrepreneurial capacity of university students with a commercial profile. These findings allow universities to evaluate the entrepreneurial capabilities of students who can promote sustainable businesses, which in turn improves the relationship between the University, state, and company.
Response of soft rock and sand compound soil structure to freeze-thaw cycles in Mu Us Sandy Land, China
Authors: Zhang Haiou , Cao Tingting , Guo Zhen , Wang Yingguo , Hou Xiandong 
Published: May 2024

In order to accurately understand the relationship between soil structure and climate feedback in the frozen soil area of Mu Us Sandy Land, China, and to explore the key control factors for the structural stability of soft rock and sand compound soil under freeze-thaw environment, the indoor freeze-thaw simulation experiment was applied. The results show that the freeze-thaw period, clay content, organic matter and their interactions have significant effects on the stability of composite soil aggregates. After 10 freeze-thaw cycles, the aggregate content in the 1:0, 1:1, 1:2, and 1:5 composite soil with a diameter greater than 1 mm decreased by 55%, 34%, 44%, and 57%, while the aggregate content with a diameter less than 1 mm increased by 91%, 70%, 66%, and 87%, and the aggregate composition of each particle size is mainly concentrated in the range of 0.25–0.5 mm. Under freeze-thaw conditions, the changes of clay and aggregate content in different proportions of composite soil is the same, all showing 1:1&gt;1:2:&gt;1:5, and 1:1 composite soil with &gt;0.25 mm aggregate content is the highest. Under freeze-thaw alternations, 1:1, 1:2 and 1:5 composite soil aggregates (&lt;0.5 mm) showed a significant positive correlation with soil organic matter, while there is no significant correlation between large aggregates (&gt;1 mm) and soil organic matter. In conclusion, the freeze-thaw cycle reduces the structural stability of composite soil aggregates, and clay are the key controlling factors for the formation and structural stability of composite soil aggregates.