bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ranolazine-Tacrolimus Interaction
Authors: Pierce Dwayne A , Reeves-Daniel Amber M 
Published: September 2010

Objective: To report the case of a kidney allograft recipient on a stable regimen of tacrolimus who exhibited increased tacrolimus concentrations within 24 hours of initiating ranolazine. Case Summary: A 64-year-old kidney allograft recipient on a stable dose of tacrolimus (10 mg twice daily) was admitted for recent worsening of her chronic anginal pain. The patient was initiated on ranolazine 500 mg twice daily on hospital day 2. Tacrolimus concentrations rose from 7.0-10.1 ng/mL preadmission to 17.8 ng/mL within 24 hours of ranolazine initiation. Ranolazine therapy was continued due to the patient's beneficial response; therefore, the tacrolimus dose was eventually decreased by 70% to 3 mg twice daily to maintain steady-state trough concentrations between 6.6 and 7.9 ng/mL with ranolazine therapy. Ranolazine dechallenge on a subsequent admission produced subtherapeutic tacrolimus concentrations requiring dosage increases. Discussion: Ranolazine, an antianginal agent, is both a substrate and a weak inhibitor of CYP3A as well as a substrate and moderate inhibitor of the P-glycoprotein (P-GP) efflux transport system. Tacrolimus, an immunosuppressant, is also a substrate of CYP3A and P-GP. Through possible inhibition of both P-GP– and CYP3A-mediated first-pass metabolism and CYP3A systemic metabolism, ranolazine may have significantly increased serum concentrations of tacrolimus necessitating an eventual 70% decrease in the tacrolimus dose. Based on the Horn Drug Interaction Probability Scale, this interaction is possible. Conclusions: We suggest that the eventual 70% decrease in tacrolimus dose after ranolazine initiation may indicate that ranolazine decreases the metabolism and clearance of tacrolimus, causing an elevation in tacrolimus concentrations and the potential for tacrolimus toxicity. Clinicians should be aware of this possible interaction when initiating ranolazine in patients on tacrolimus.
Cold‐blooded lie catchers? An investigation of psychopathy, emotional processing, and deception detection
Authors: Peace Kristine A. , Sinclair Sarah M. 
Published: September 2010

Purpose. The process of catching liars is challenging, though evidence suggests that deception detection abilities are influenced by the characteristics of the judge. This study examined individual differences in emotional processing and levels of psychopathic traits on the ability to judge the veracity of written narratives varying in emotional valence.Methods. Undergraduate participants (N= 251) judged the veracity of 12 written narratives (truthful/deceptive) across three emotional categories: positive, negative, and neutral events. Levels of psychopathy were assessed to investigate its relation to accuracy and cue use.Results. Overall accuracy was close to chance, although participants were more accurate in determining the veracity of truthful relative to deceptive narratives. Accuracy was impaired for emotional (positive and negative) relative to neutral narratives. Psychopathy was not associated with levels of overall accuracy, but related to discriminative ability, and differential use of cues in decision making. Reported cue use also differed across emotional narrative conditions.Conclusions. We speculated that an emotive truth bias may have detracted judges from attending to valid cues that are indicative of the deceptive nature of stimuli because they were distracted by the emotional content of the report. Implications for deception detection in forensic settings are discussed.
Sol-gel synthesized NaLu1-xYbx(WO4)2 heteroepitaxial films for laser applications
Authors: Han Xiumei , Zaldo Carlos 
Published: September 2010

AbstractNaLu1-xYbx(WO4)2 films have been prepared by spin coating of sol-gel precursor solutions and thermal annealing between 400 and 800 °C. Films obtained on sapphire have a dense and transparent ceramic microstructure and photoluminescence properties similar to those of single crystals with same composition. The application of these films as laser media is envisaged.
Detecting Insect Infestation: A Novel Application of Carbon/Polyethylene-co-vinyl Acetate Sensors
Authors: Weerakoon Kanchana Anuruddika , Chin Bryan A 
Published: September 2010

AbstractPlants, when attacked by herbivores emit plant volatile compounds as a defensive mechanism to protect themselves from herbivores and parasites. Secreting these volatiles is not only toxic towards these insects but also aids enemies of the herbivores to recognize infested plants to locate their prey. A low mass fraction carbon black/polyethylene-co-vinylacetate composite sensor was designed and fabricated to detect insect infestation. This sensor was cost efficient, easy to fabricate and was highly stable in air. When an organic vapor is present, the carbon/polymer active layer swells creating a discontinuity in the conducting pathway between adjacent carbon particles, increasing the resistance of the film. When the analyte is no longer present, the polymer will return to its original state, showing a decrease in resistance. A variety of Carbon/black polymer sensors with varying chemical characteristics could be created by using different polymer matrices. Polyethylene-co-vinyl acetate was chosen as the best polymer for this particular application based on its swelling ability in the presence of plant volatiles compared to other polymers. When the carbon concentration of the active layer was low enough to be near the percolation threshold, the sensor can be used as a “chemical switch”. The resistance of the sensor increased significantly mimicking a “switch off” response when exposed to the analyte vapor. When the analyte vapor was no longer present the sensor returned back to its original condition, showing a “switch on” response. The percolation point was obtained when the carbon concentration of the carbon/polymer composite was kept between 0.5-1 wt%. The sensor was tested and found to be sensitive to a variety of volatile organic compounds emitted during insect infestation including γ-terpinene, α-pinene, p-cymene, farnesene, and limonene and cis-hexenyl acetate.
Bio-composite Materials for the Detection of Estrogen in Water Using Piezoresistive Microcantilever Sensors
Authors: Porter Timothy L. , Vail Tim , Propper Catherine , Islam Nazmul 
Published: September 2010

AbstractEmbedded piezoresistive microcantilever (EPM) sensors were used to detect the presence of the compound estrogen in water samples. The sensor was fabricated with a host material hydrogel (Hypol) functionalized with estrogen antibody. This sensor was able to detect 1 ppm of estrogen in water, responding almost immediately to the estrogen addition, with a full sensor response (saturation) occurring after two minutes of exposure.
A Biosensor System for the Detection of Salmonella Typhimurium Using Multiple Phage-based Magnetoelastic Biosensors
Authors: Shen Wen , Li Yugui , Chen Huiqin , Horikawa Shin , Chin B. A. 
Published: September 2010

AbstractMagnetoelastic (ME) sensors provide a fast, sensitive method to detect bacteria with smaller sensors have higher mass sensitivity for detecting lower concentrations of bacteria. However, signals from smaller sensors are weaker and have more noise due to manufacturing defects. In this paper, we present a biosensor system for the detection of Salmonella typhimurium using multiple magnetoelastic sensors, each with the size of 2000 × 400 × 30 μm. The sensors are immobilized with E2 phage, which specifically binds with S. typhimurium. Unlike traditional methods, our system uses a step pulse to “shock” the sensor, causing it to vibrate at its natural resonance frequency and produce a signal in the pickup coil due to reverse magnetostriction. A Fast Fourier Transform (FFT) was used to determine the resonance frequency. As the biosensor captures S. typhimurium cells, its mass increases with a corresponding decrease of its resonance frequency.The detection system was composed of one coil with a reference sensor to monitor stability, and another coil with three measurement sensors separated in three tubes for simultaneous detection of bacteria. With multi-sensors the effect of a manufacturing defect is decreased and we get the benefit of averaging for more accurate and reliable results. Stability tests show that the variance of frequency detection is less than 122 ppm of its resonance frequency. SEM pictures of the sensor surface show a uniform binding of S. typhimurium cells. Cells were counted and the mass change calculated. The measured frequency change corresponds well to the theoretical change. The results show that the multiple phage based ME biosensors are able to simultaneously detect S. typhimurium and offer good sensitivity and reliability of detection.
Local Electromechanical Properties of CaCu3Ti4O12 Ceramics
Authors: Tararam Ronald , Bdikin Igor , Varela Jose , Bueno Paulo R , Kholkin Andrei L. 
Published: September 2010

AbstractScanning probe microscopy (SPM) was used to probe piezoelectric vibrations and local conductivity in CaCu3Ti4O12(CCTO) ceramics at room temperature. Piezoelectric contrast was observed on the polished surfaces of CCTO in both vertical (out-of-plane) and lateral (in-plane) modes and depended on the grain orientation varying in sign and amplitude. The piezoelectric contrast is shown to be controlled by the electrical bias (local poling) and displayed a ferroelectric-like reversible hysteresis accompanied with a change of the phase of piezoelectric signal. Flexoelectric effect (strain-gradient-induced polarization) due to surface relaxation was invoked to explain the observed contrast inside the grains.
Structure/Property Relations in Bulk Versus Solution Derived Proton Conducting Ceramics of the Form SrCe0.95Yb0.05O3 With Applications in Membrane Separations
Authors: Brinkman Kyle , Fox Elise B , Korinko Paul , Lascola Robert , Liu Qiang , Chen Fanglin 
Published: September 2010

AbstractMembrane separations are a key enabling technology for future energy conversion devices. Ionic transport membranes must have both proton and electronic conductivity to function as hydrogen separation membranes without an external power supply. A technical obstacle to material modification by compositional changes is that the hydrogen flux through a dense membrane is a function of both the proton ionic conductivity and the electronic conductivity. An alternative way to modify the materials conductivity without changing the ratio of the chemical constituents is by altering the microstructure. In this study, SrCe0.95Yb0.05O3 was produced by conventional mixed oxide bulk ceramic techniques and chemical solution routes self-rising approaches using urea as the leavening agent. In conventional ceramic processing routes, the perovskite phase was observed to form at temperatures near 1300oC, while solution techniques resulted in perovskite phase formation starting near 1000oC with complete phase transformations occurring at 1100oC. Thermogravimetric analysis (TGA) was conducted in various gas atmospheres resulting in bulk oxide route powders exhibiting a 0.6% weight loss at 800oC under a nitrogen environment as compared to chemically derived powders which displayed weight losses on the order of 3.4%.The increased weight loss observed in chemically derived SrCe0.95Yb0.05O3 is correlated with an increase in the number of electron charge carriers and results in elevated electronic conduction. This study will report on the development of structure property relations in the model proton conducting ceramic system SrCe0.95Yb0.05O3.
Fabrication of Electrode With 3 Dimensionally Ordered Structure for All-Solid-State Battery
Authors: Kotobuki Masashi , Kanamura Kiyoshi 
Published: September 2010

AbstractFabrication of all-solid-state Li battery has been strongly required to overcome safety issue of present Li battery. One of promising structures for ceramics electrolyte in all-solid-state battery is 2-layered structure composed of 3 dimensionally ordered macroporous layer (3DOM) and dense layer. In this study, we prepared LLT ceramics electrolyte with the 2-layered structure by suspension filtration method. Thicknesses of the dense and the porous layers were about 17 and 111 μm, respectively. The porous layer involved uniform pores of 1.8 μm in diameter. An electrochemical property of LiMn2O4/2-layered LLT composite, prepared by impregnation of precursor sol for LiMn2O4 into the pores followed by calcination, was tested. A rechargeable behavior of the composite electrode was clearly observed. From this result, it can be said that the composite can work as rechargeable battery. The discharge capacity of the composite was 27 mA h g-1.
Enhancement of On-chip Bioassay Efficiency With Electrothermal Effect
Authors: Huang K. R. , Chang J. S. , Chao Sheng Der , Wu K. C. 
Published: September 2010

AbstractWe have performed the finite element simulations to study the binding reaction kinetics of the analyte-ligand protein pairs, C-reactive protein (CRP) and anti-CRP, in a reaction chamber of a biosensor. For diffusion limited reactions, diffusion boundary layers often develop on the reaction surface, thus hindering the reaction. To enhance the efficiency of a biosensor, a non-uniform AC electric field is applied to induce the electrothermal force which stirs the flow field. Biosensors with different arrangements of the electrode pairs and the reaction surface are designed to study the effects of geometric configurations on the binding efficiency. The maximum initial slope of the binding curve can be 6.94 times of the field-free value in the association phase, under an AC field of 15 rms and an operating frequency of 100 kHz. With the electrothermal effect, it is possible to use a slower flow and save much sample consumption without sacrificing the performance of a biosensor. Several design factors not studied in our previous works such as the thermal boundary conditions are discussed.
Experimental Characterization of the Whipping Instability of Charged Microjets in Liquid Baths
Authors: Riboux Guillaume , Gómez-Marín Álvaro , Barrero Antonio , Fernández-Nieves Alberto , Loscertales Ignacio G. 
Published: September 2010

AbstractCapillary liquid flows have shown their ability to generate micro and nano-structures which can be used to synthesize material in the micro or nanometric size range. For instance, electrified capillary liquid jets issued from a Taylor are broadly used to spin micro and nanofibers when the liquid consists of a polymer solution or melt, a process termed electrospinning. In this process, the electrified capillary jet may develop a nonaxisymmetric instability, usually referred to as whipping instability, which very efficiently transforms electric energy into stretching energy, thus leading to the formation of extremely thin polymer fibers. Even though non axysimmetric instabilities of electrified jets were first investigated some decades ago, the existing theoretical models provide a qualitative understanding of the phenomenon but none of them is accurate enough when compared with experimental results. This whipping instability usually manifests itself as fast and violent lateral motion of the charged jet, which makes it difficult its characterization in the laboratory. However, this instability also develops when electrospinning is performed within a liquid bath instead of air. Although it is essentially the same phenomenon, the frequency of the whipping oscillations is much slower in the former case than in the latter, thus allowing detailed experimental characterization of the whipping instability. Furthermore, since the outer fluid is a liquid, its density and viscosity may now be used to influence the dynamics of the electrified capillary jet. In this work we present and rationalize the experimental data collecting the influence of the main parameters on the whipping characteristics of the electrified jet (frequency, amplitude, etc.).
Toward a Merged Microfluidic/Microelectrode Array Device for Culture of Unidirectional Neural Network
Authors: Mo Alexander , Heilshorn Sarah 
Published: September 2010

AbstractTraditional neural cultures are formed from disassociating primary neurons that are sourced from animals. However by disassociating them, any larger organizational structure between the neurons is lost. In an effort to regain some of the lost organization a device that is capable of recreating and monitoring a unidirectional connection between two populations is proposed. Initial validation toward a fully functional device is presented. Using soft lithography techniques, a microfluidic chip has been designed and produced with a design conducive for facilitating such a neuron culture. Using a specialized adhesive method, this chip can be attached and removed from a commercially available microelectrode array. Finally, cell viability is demonstrated using the PC12 neuron-like cell line after exploring several device configurations. Further efforts will be focused on primary neuron culture and establishment of a unidirectional network.
Control of the Surface Properties of Microfludic Devices by Using Polyelectrolyte Multilayer Coatings
Authors: Park Hyun , An Yoo-Jin , Yang Sung Yun 
Published: September 2010

AbstractRecently, more studies have been conducted in chemical and biological applications using microfluidic or nanofluidic devices.1 Polymer-based materials have been newly developed in this field due to the great needs of easy processing, cost-effectiveness and clarity for the material. However, it is still challenging to control of the surface properties of these devices on demand. Especially, for biological analysis or detection, micro-fluidics should handle aqueous samples but, most of the current materials in use for micro-fluidic devices are relatively hydrophobic (such as PDMS, PMMA and cyclo-olefin-co polymer, etc). Therefore, they usually need an extra assistance rather than a capillary force to flow the aqueous samples. In this paper, we utilized layer-by-layer deposition of polymer to modify the surface of the micro-channel of the device in order to control surface properties of the micro-channel. We have been studied polyelectrolyte multilayer(PEM) coatings to control surface wettability of the open structures and found various hydrophilic films. Here we demonstrate polyelectrolyte multilayer film as an effective coating for inner surface of micro-fluidic devices to lowering the water contact angle, so that the aqueous fluid will travel smoothly with the channels. Compared to the other surface treatment method such as base cleaning or plasma irradiation, the PEM coating exhibit highly sustained water wettability. Polyelectrolytes used for this study are weak polyelectrolytes including biodegradable polymer such as poly(hyaluronic acid) (HA) for future biological applications.
Fabrication and Applications of Three Dimensional Porous Microwells
Authors: Randall Christina L , Kalinin Yevgeniy V , Azam Anum , Gracias David 
Published: September 2010

AbstractIn many biological applications, such as cell therapy and drug delivery, there is a need to enhance diffusion by enabling chemical transport in all three dimensions. We highlight this need by comparing diffusion in a conventional two-dimensional (2D) microwell with diffusion in a three-dimensional (3D) cubic microwell using numerical simulations. We also describe the fabrication of hollow polymeric (and biocompatible) cubic microwells and microwell arrays. We emphasize that since the assembly process is compatible with 2D lithographic patterning, porosity can be precisely patterned in all three dimensions. Hence, this platform provides considerable versatility for a variety of applications.
I Scratched Yours: The Prevalence of Reciprocation in Feedback Provision on eBay
Authors: Jian Lian , MacKie-Mason Jeffrey K , Resnick Paul 
Published: September 2010

Abstract
Many online systems for bilateral transactions elicit performance feedback from both transacting partners. Such bilateral feedback giving introduces strategic considerations. We focus on reciprocity in the giving of feedback: how prevalent a strategy of giving feedback is only if feedback is first received from one's trading partner. The overall level of feedback activity clearly depends on the prevalence of the reciprocation strategy: in a market with many reciprocators and few unconditional feedback providers, the equilibrium quantity of feedback can be quite low. We estimate the prevalence of such reciprocation in one market, eBay. Reciprocation cannot be directly distinguished from late feedback that was not conditioned on the partner having provided feedback. We develop a model that distinguishes the two by exploiting information about the timing of feedback provision when the partner does not provide feedback. We find that buyers and sellers on eBay used the reciprocate only strategy about 20-23% of the time. We also measure the extent to which the prevalence of these strategies changes with the experience levels of the two parties and with the item price.
Differential Adaptation of Human Gut Microbiota to Bariatric Surgery–Induced Weight Loss
Authors: Furet Jean-Pierre , Kong Ling-Chun , Tap Julien , Poitou Christine , Basdevant Arnaud , Bouillot Jean-Luc , Mariat Denis , Corthier Gérard , Doré Joël , Henegar Corneliu , Rizkalla Salwa , Clément Karine 
Published: September 2010

OBJECTIVE
Obesity alters gut microbiota ecology and associates with low-grade inflammation in humans. Roux-en-Y gastric bypass (RYGB) surgery is one of the most efficient procedures for the treatment of morbid obesity resulting in drastic weight loss and improvement of metabolic and inflammatory status. We analyzed the impact of RYGB on the modifications of gut microbiota and examined links with adaptations associated with this procedure.

RESEARCH DESIGN AND METHODS
Gut microbiota was profiled from fecal samples by real-time quantitative PCR in 13 lean control subjects and in 30 obese individuals (with seven type 2 diabetics) explored before (M0), 3 months (M3), and 6 months (M6) after RYGB.

RESULTS
Four major findings are highlighted: 1) Bacteroides/Prevotella group was lower in obese subjects than in control subjects at M0 and increased at M3. It was negatively correlated with corpulence, but the correlation depended highly on caloric intake; 2) Escherichia coli species increased at M3 and inversely correlated with fat mass and leptin levels independently of changes in food intake; 3) lactic acid bacteria including Lactobacillus/Leuconostoc/Pediococcus group and Bifidobacterium genus decreased at M3; and 4) Faecalibacterium prausnitzii species was lower in subjects with diabetes and associated negatively with inflammatory markers at M0 and throughout the follow-up after surgery independently of changes in food intake.

CONCLUSIONS
These results suggest that components of the dominant gut microbiota rapidly adapt in a starvation-like situation induced by RYGB while the F. prausnitzii species is directly linked to the reduction in low-grade inflammation state in obesity and diabetes independently of calorie intake.