bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship of left piriform cortex network centrality with temporal lobe epilepsy duration and drug resistance
Authors: Zahnert Felix , Reichert Paul , Linka Louise , Timmermann Lars , Kemmling André , Grote Alexander , Nimsky Christopher , Menzler Katja , Belke Marcus , Knake Susanne 
Published: February 2025

AbstractBackgroundWe investigated the relationship of piriform cortex (PC) structural network centrality with drug resistance and epilepsy duration as markers of sustained epileptic activity.MethodsPCs were manually delineated on retrospectively collected 3D‐T1‐MRI images of patients with temporal lobe epilepsy (TLE). Connectomes were computed from diffusion MRI scans, including the PC as network nodes. Betweenness centrality (BC) and node degree were computed and compared across drug‐resistant versus drug‐sensitive patients. Correlations of centrality metrics with the duration of epilepsy were calculated.ResultsSixty‐two patients (36 females, 43/62 drug‐resistant) were included in the main analysis. Greater centrality of the left PC was associated with drug resistance (degree: p = 0.00696, d = 0.85; BC: p = 0.00859, d = 0.59; alpha = 0.0125). Furthermore, left PC centrality was correlated with epilepsy duration (degree: rho = 0.39, p = 0.00181; BC: rho = 0.35, p = 0.0047; alpha = 0.0125). Results were robust to analysis of different parcellation schemes. Exploratory whole‐network analysis yielded the largest effects in the left PC. Finer parcellations showed stronger effects for both analyses in the left olfactory cortex rostral to PC. In 28 subjects who had received epilepsy surgery, a trend of smaller centrality in patients with ILAE I outcome was observed in this area.ConclusionsWe demonstrated an increased centrality of the left PC in patients with drug‐resistant TLE, which was also associated with the epilepsy duration. Recurring seizures over long periods may lead to changes of network properties of the PC. Large effects immediately rostral to our delineated PC region suggest a role of olfactory cortex anterior to the limen insulae in epileptogenic networks.
Effect on mechanical and microbiological properties of adding calcium glycerophosphate and xylitol to glass ionomer cement
Authors: de Azevedo Santana Juliana , de Lima Navarro Maria Fidela , Gomes Leonardo Fernandes , Brighenti Fernanda Lourenção , de Oliveira Analú Barros , Fernandes Gabriela Leal Peres , Nunes Gabriel Pereira , Danelon Marcelle 
Published: February 2025

AbstractThis study aimed to evaluate the effect on the mechanical and microbiological properties of incorporating calcium glycerophosphate (CaGP) and/or xylitol into resin modified glass ionomer cement (RMGIC). Six experimental cements were tested: i) RMGIC without additions; and RMGIC with ii) 5% xylitol; iii) 10% xylitol; iv) 3% CaGP; v) 3% CaGP and 5% xylitol, or vi) 3% CaGP and 10% xylitol. The compressive strength, diametral tensile strength and surface hardness were determined (24 h and 7 days). Antimicrobial/antibiofilm activity was evaluated. Compressive strength values after 24 h for +3% CaGP & 5% xylitol were higher and similar to RMGIC. After 7 days, +3% CaGP & 5% xylitol presented the highest compressive strength values. The +3% CaGP & 10% xylitol showed the lowest values of diametral tensile strength values (24 h). The RMGIC with +3% CaGP & 5% xylitol showed the highest diametral tensile strength (7 days). The surface hardness (24 h) were highest for the RMGIC and +10% xylitol. After 7 days, +3% CaGP & 5% xylitol showed the highest value. The +3% CaGP & 5% xylitol or +3% CaGP & 10% xylitol showed the lowest levels of microbial/biofilm formation. The addition of CaGP/xylitol promoted improved the mechanical and antibacterial properties of RMGIC.
Bond mutual fund performance: Evidence from the skill ratio and false discovery rate
Authors: Huang Lifa , Lee Wayne Y. , Rennie Craig G. 
Published: February 2025

AbstractThis paper applies a Skill Ratio under a False Discovery Rate (FDR) framework to bond mutual funds showing many bonds mutual fund managers are skilled primarily to the benefit of fund sponsors. Our Skill Ratio is the t‐statistic of realized gross value added based on investible Morningstar benchmark‐adjusted monthly returns times the natural logarithm of assets under management (AUM). We apply a new simulation process for FDR that mitigates small sample bias and mis‐discovery on tails. For 571 actively managed domestic bond mutual fund managers between 1999 and 2016, 28.7% are skilled, including 36.3% of 226 corporate funds and 17.3% of 345 government funds.
Varying Thermal Dependence of Life History Traits Predicts Responses to Environmental Change in Aquatic Amphibian Larvae
Authors: Tahalová Kamila , Šugerková Monika , Gvoždík Lumír 
Published: February 2025

ABSTRACT

Many organisms respond to environmental changes through plastic modifications of their phenotypes. While phenotypic plasticity has been extensively studied in response to single factors in laboratory settings, organisms in nature face the combined effects of diverse biotic and abiotic stressors. These multistressor effects complicate predictions about the impact of environmental changes on population dynamics. One approach to improving predictive accuracy is to identify common mechanistic links to variations in life‐history traits. In this study, we examined how biotic and abiotic stressors influence life‐history variation, using predictions based on the differing thermal sensitivities of differentiation and growth rates in aquatic amphibian larvae and their subsequent impact on the behaviour of terrestrial juveniles.

Using a mesocosm experiment, we exposed larvae of two sympatric newt species, Ichthyosaura alpestris and Lissotriton vulgaris, to combinations of a biotic factor (the presence of heterospecifics) and an abiotic factor (simulated drying).

Our results revealed that simulated drying increased the availability of high water temperatures, thereby shortening the larval period as predicted by the high thermal sensitivity of differentiation rates. The presence of heterospecifics, not drying regime, increased the size at emergence in the larger species, I. alpestris, consistent with the relatively low thermal sensitivity of growth rates. The impact of drying carried over to the terrestrial juveniles, affecting their covered distance in both taxa, while the presence of heterospecifics influenced maximum voluntary speed during exploratory behaviour in I. alpestris juveniles.

This suggests that the additive effects of biotic and abiotic factors on subsets of life‐history and behavioural traits combine at the individual level, depending on species identity.

Future research should focus on the interplay between ecologically‐realistic thermal conditions and species interactions within pond larval assemblages to understand the impact of environmental changes on amphibian population dynamics.
Greenhouse Gas Emissions and Lateral Carbon Dynamics at an Eroding Yedoma Permafrost Site in Siberia (Duvanny Yar)
Authors: Keskitalo Kirsi H. , Bröder Lisa , Jong Dirk J. , Mann Paul J. , Tesi Tommaso , Davydova Anna , Zimov Nikita , Haghipour Negar , Eglinton Timothy I. , Vonk Jorien E. 
Published: February 2025

ABSTRACTRapid Arctic warming is accelerating permafrost thaw and mobilizing previously frozen organic carbon (OC) into waterways. Upon thaw, permafrost‐derived OC can become susceptible to microbial degradation that may lead to greenhouse gas emissions (GHG), thus accelerating climate change. Abrupt permafrost thaw (e.g., riverbank erosion, retrogressive thaw slumps) occurs in areas rich in OC. Given the high OC content and the increase in frequency of abrupt thaw events, these environments may increasingly contribute to permafrost GHG emissions in the future. To better assess these emissions from abrupt permafrost thaw, we incubated thaw stream waters from an abrupt permafrost thaw site (Duvanny Yar, Siberia) and additionally, waters from their outflow to the Kolyma River. Our results show that CO2 release by volume from thaw streams was substantially higher than CO2 emissions from the river outflow waters, while the opposite was true for CO2 release normalized to the suspended sediment weight (gram dry weight). The CH4 emissions from both thaw streams and outflow waters were at a similar range, but an order of magnitude lower than those of CO2. Additionally, we show that nearshore riverbank waters differ in their biogeochemistry from thaw streams and Kolyma River mainstem: particles resemble thaw streams while dissolved fraction is more alike to the Kolyma River thalweg. In these waters dissolved OC losses are faster than in the river thalweg. Our incubations offer a first insight into the GHG release from permafrost thaw streams that connect exposed and degrading permafrost outcrops to larger river systems.
Understanding the Catch‐Up Innovation in China: A Perspective of Local Government Competition
Authors: Guo Jin , Wei Zhi , Xu Yingzhi 
Published: February 2025

ABSTRACTThis paper delves into the phenomenon of catch‐up innovation in China, examining it through the institutional framework of local government innovation competition. Our theoretical modeling indicates that in order to perform well in performance appraisals and obtain a greater probability of promotion, local governments tend to implement excessive policy incentives, ultimately sparking an intense competition for innovation among regions in China. Empirical analyses corroborate the effectiveness of supportive policies in fostering local innovation. Nonetheless, excessive policy intervention has exhibited a propensity to stifle local innovation performance. In the spatial dimension, regional innovation competition demonstrates notable positive spatial effects, while the potential negative spatial effects of excessive competition have yet to emerge. By scrutinizing the influence of regional innovation competition on patent knowledge width and patent types, we conclude that regional innovation competition is unlikely to alleviate the issue of low‐quality innovation in China. Consequently, this paper advocates for the urgent enhancement of the official evaluation system by incorporating indicators pertaining to innovation quality, thereby amplifying the positive impact of regional innovation competition on patent quality. Simultaneously, the official evaluation system should remain vigilant against the detrimental effects of excessive competition and facilitate the transition from regional innovation competition to regional innovation cooperation through the optimization of local government behavior.
Factor VIII Activity and Factor VIII Inhibitors Can Be Measured Accurately in Plasma Containing Mim8 by Using Specific Chromogenic Assays
Authors: Pickering William , Robinson Mary , Cogswell Caroline , Clausen Wan Hui Ong , Weldingh Karin Nana , Ezban Mirella 
Published: February 2025

ABSTRACTIntroductionPatients with Haemophilia A treated with Mim8 may require concomitant Factor VIII (FVIII) replacement; hence, accurate assessment of FVIII activity (FVIII:C) and FVIII inhibitors in the presence of Mim8 is important.AimAssess which chromogenic substrate assays (CSAs) accurately monitor FVIII:C and FVIII inhibitor levels in the presence of Mim8.MethodsFVIII and Mim8 were spiked into congenital FVIII‐deficient plasma to obtain mixtures containing various FVIII:C levels (0–100 IU/dL) and Mim8 concentrations (0, 3, 6 and 12 µg/mL). Five CSAs using different activated Factor IX and X sources (bovine, bovine–human or human) were used to measure FVIII:C. Bovine and bovine–human CSAs were then used to measure FVIII:C of standard half‐life (SHL) and extended half‐life (EHL) FVIII products. FVIII inhibitor levels were assessed using two different bovine CSAs in congenital FVIII‐deficient plasma spiked with various Mim8 concentrations (5, 10, 20 and 40 µg/mL) and FVIII inhibitor levels (0.2, 1.0 and 4.8 BU).ResultsHigh levels of interference were observed using human CSAs. Bovine CSAs accurately measured FVIII:C of SHL and EHL FVIII products in the presence of Mim8 without interference. In bovine–human CSAs, interference was observed at 5 IU/dL FVIII, increasing up to four‐fold with increasing Mim8 levels. FVIII inhibitor levels were accurately measured using bovine CSAs without Mim8 interference.ConclusionFVIII:C of SHL and EHL products and FVIII inhibitor levels can be accurately monitored in the presence of Mim8 using bovine CSAs at all FVIII levels, and bovine–human CSAs at FVIII concentrations >20 IU/dL.
Registry‐Based Surveillance of Severe Acute Respiratory Infections in Norway During 2021–2024
Authors: Seppälä Elina , Bøås Håkon , Dahl Jesper , Stålcrantz Jeanette , Stecher Melanie , Tønnessen Ragnhild , Rø Gunnar Øyvind Isaksson , Kløvstad Hilde , Paulsen Trine Hessevik 
Published: February 2025

ABSTRACTBackgroundIn 2021, the Norwegian Institute of Public Health established temporary registry‐based surveillance of severe acute respiratory infections (SARI). We aimed to describe the surveillance system and evaluate selected attributes to inform the establishment of a permanent SARI surveillance system.MethodsSARI cases were defined using ICD‐10 discharge codes from national health and administrative registries, including codes for acute upper or lower respiratory infection (URI and LRI), COVID‐19, acute respiratory distress syndrome, pertussis or otitis media. Data from polymerase chain reaction (PCR) analyses were available for 10 respiratory pathogens including SARS‐CoV‐2, influenza virus and respiratory syncytial virus (RSV). We included data from 28 September 2020 to 31 March 2024 and calculated the following parameters: the proportion of cases tested for SARS‐CoV‐2, influenza virus and/or RSV; time between admission and registration of a SARI‐related ICD‐10 code; and proportion of cases with URI, LRI and COVID‐19.ResultsWe identified 214,730 SARI cases, of whom 82%, 73% and 53% were tested for SARS‐CoV‐2, influenza virus and RSV. Case peaks were predominantly driven by one or a combination of these pathogens. Median time between admission and a registered SARI diagnostic code was 5 (lower–upper quartile 3–10) days. Nowcasting and alternative case definitions for SARI with COVID‐19, influenza and RSV improved the timeliness. The ICD‐10 codes for LRIs and COVID‐19 captured only ~55% of the cases in the age group of 0–29 years compared to the routine case definition, where URIs were included.ConclusionsRegistry‐based SARI surveillance provides timely data for handling epidemics of respiratory infections in Norway. We recommend establishing a permanent SARI surveillance system.
Streamflow Intervals Prediction Using Coupled Autoregressive Conditionally Heteroscedastic With Bootstrap Model
Authors: Bickici Bugrayhan , Beyaztas Beste Hamiye , Yaseen Zaher Mundher , Beyaztas Ufuk , Kahya Ercan 
Published: February 2025

ABSTRACTStreamflow (Qflow) process is one of the complex stochastic processes in the hydrology cycle owing to its associated non‐linearity and non‐stationarity characteristics. It is an essential hydrological process to address the complex time series nonlinear phenomena. In this research, a novel approach was proposed by integrating an autoregressive conditionally heteroscedastic (ARCH) method with bootstrap model to predict future Qflow intervals. For this purpose, two Qflow series located at the Eastern Black Sea basin (Turkey) were subjected to the application of the proposed methodology. Among other regression and machine learning (ML) models, which are suitable for Qflow modeling, the autoregressive integrated moving average (ARIMA), seasonal autoregressive integrated moving average (SARIMA), and artificial neural network (ANN) were selected for modeling validation in this study. A group of three numerical metrics and graphical presentations were used for the modeling evaluation and assessment. The proposed ARCH approach performed a superior mathematical model to address the Qflow interval prediction. Remarkable prediction accuracy was shown against the benchmark models. Overall, the approach of coupling the bootstrap procedure with the ARCH model exhibited a robust modeling strategy for predicting Qflow intervals suggested as a new analysis tool.
Is Our Attachment Hurting Us? Unraveling the Associations Between Partners' Attachment Pairings, Negative Emotions During Conflict, and Intimate Partner Violence
Authors: Pudelko Apollonia Helena , Ramos Brenda , Emond Marianne , Péloquin Katherine , Daspe Marie‐Ève 
Published: February 2025

ABSTRACTAttachment insecurities and heightened negative emotions during conflict are significant risk factors for intimate partner violence (IPV). Previous research mainly examined each partner's attachment separately and overlooked negative emotions as a mechanism in the attachment–IPV link. This dyadic observational study conducted among 178 young adult couples examined (1) the interplay between both partners' attachment (i.e., pairings) in association with their IPV perpetration and (2) the contribution of negative emotions during a conflict discussion in these associations. Results revealed that one's avoidance was positively linked with their IPV only when their partner showed low levels of avoidance. One's avoidance was also indirectly associated with their own IPV through their own negative emotions, and to their partner's IPV via their partner's negative emotions. Finally, one's anxiety was indirectly linked with their own IPV through their own negative emotions. Findings support prevention and intervention strategies for IPV that target attachment and negative emotions.
Care Work, Labour Control and the Gendered Social Reproduction of a Semi‐Landless Class in 19th Century Sweden
Authors: Uppenberg Carolina 
Published: February 2025

ABSTRACTThis article shows how the reproductive work in the households of the semi‐proletarianized Swedish group termed crofters (Sw: torpare) ensured subsistence for the crofters and increased capital accumulation for large landowners. Crofters lived under partly proletarianized, partly feudal conditions and their labour organization illuminates the proletarianization during the 19th century. Through two concepts from the field of Marxist‐feminist social reproduction theory, Alessandra Mezzadri's ‘value theory of inclusion’ and Nancy Fraser's ‘contradictions of care’, it is shown how the landowner externalized the costs of reproductive care work to be absorbed by the crofter households. This increased labour control, and the reproductive labour of the crofter household increased the value of the land for the landowner, allowing for capital accumulation. The analysis shows a process in which the crofter institution underwent a formal subsumption of labour, keeping the forms intact but increasingly contributing to capital accumulation through the organization of reproduction.
Retrospective Review of 2851 Female Patients With Telogen Effluvium: A Single‐Center Experience
Authors: Karakoyun Ömer , Ayhan Erhan , Yıldız İsmail 
Published: February 2025

ABSTRACTObjectiveTelogen effluvium, the most common cause of diffuse and non‐scarring alopecia in women, is frequently diagnosed in dermatology outpatient clinics and can be caused by various etiological factors such as medications, trauma, emotional, and physiological stress. In patients presenting with complaints of telogen effluvium, we aimed to investigate abnormal levels of serum ferritin, vitamin B12, folic acid, thyroid function tests, and hemoglobin and determine which of these abnormal values might be significantly associated with telogen effluvium.Material and MethodsIn this study, 2851 female patients diagnosed with telogen effluvium who applied to the Dicle University Dermatology outpatient clinic between January 1, 2010 and June 30, 2024 were retrospectively evaluated. The relationship between these laboratory abnormalities and telogen effluvium, as well as their significance in different age groups, was analyzed using the SPSS‐27.0 program. Associations were analyzed using Kolmogorov–Smirnov test, dependent t‐test, Wilcoxon test, Pearson chi‐square (χ2) test, Yates chi‐square (χ2) test, Fisher chi‐square (χ2) test analysis, Mc‐Nemar test, Pearson/spearman correlation analysis, and logistic regression analysis. A p value of < 0.05 was considered statistically significant.ResultsThe mean age of 2851 female patients included in our study was 26.33 years, 12.8% (n = 366) were under 18 years of age, 83.5% (n = 2380) were between 18 and 45 years of age, and 3.7% (n = 105) were over 45 years of age. Hemoglobin values were determined in 2496 of 2851 patients and values below the reference range were found in 317 patients (11.1%). Ferritin was found to be low in 1123 (46.5%) of 2413 patients. Vitamin 12 deficiency was detected in 150 (5.8%), folic acid deficiency in 8 (0.6%), and iron deficiency in 685 (29.5%) patients. As can be seen in our study, deficiency of laboratory parameters, especially ferritin and serum iron, is a common finding in female patients presenting with TE.ConclusionThis study showed that biochemical tests, complete blood counts, and hormonal tests are important tools in investigating the etiology and guiding the treatment in patients diagnosed with telogen effluvium, as various etiological factors may be present. Furthermore, it was determined that parameters such as vitamin B12, ferritin, TSH, and T3 hold varying levels of importance during significant phases of women's physiological development, such as adolescence and post‐menopausal periods.
Clinician Perspectives on Using Plastic Cannula for Vascular Access in Haemodialysis: Outcomes of a National Web‐Based Survey
Authors: Smith Vicki , Schoch Monica 
Published: February 2025

ABSTRACTBackgroundPlastic cannulae were introduced into Australia over a decade ago as a safer alternative to metal dialysis needles for arteriovenous fistula cannulation, decreasing the risk of infiltration resulting in haematoma formation, bruising, and pain for patients.ObjectivesTo explore the uptake and current practices for using plastic cannulae for vascular access in Australian dialysis units.DesignA 31‐item exploratory descriptive web‐based cross‐sectional survey.ParticipantsRenal clinicians who cannulate arteriovenous fistulae or arteriovenous grafts for haemodialysis in Australian haemodialysis units.ResultsA total of 185 clinicians responded to the questionnaire, with the majority of respondents from the Australian east coast Australia, specifically Queensland (36%, n = 66), New South Wales (27%, n = 50) and Victoria (26%, n = 48). Sixty‐five percent of respondents were either registered nurses (47%, n = 88) or clinical nurse specialists (18%, n = 34). Of 140 participants who reported plastic cannula availability, only 62 (44%) used them personally. Plastic cannulae were mainly used with new (n = 55/65, 85%) and established (n = 56/60, 90%) vascular access, but rarely in home haemodialysis (n = 7/60, 11%). Plastic cannula was commonly used for the first 2 weeks with new fistula, then switched to metal needles due to high cost, however 41% (n = 22/54) reported that decisions on long‐term cannula use was based on patient clinical needs. Training and gauge of cannula varied by state, with 16‐guage the most common.ConclusionPlastic cannula use is increasing across Australia, but cost and training barriers still exist. Nevertheless, plastic cannulae remain a viable alternative to metal needles.