bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Characterization of Mesoporous Bismuth Nanopowders as a Stabilizer of 2‐Aminophenol under Ultraviolet Light
Authors: Kellou H. , Boudinar S. , Souici A. , Benbrahim N. , Hamadou L. , Belkhalfa H. 
Published: June 2024

AbstractIn this paper, a mesoporous bismuth nanopowders (Bi‐NPWs) were synthesized by chemical method and used as photosbilizer agent. The formation and stability of Bi in the solution was monitored by UV‐Vis analysis, the results shows a strong plasmonic band near 270 nm, which confirms the reduction of bismuth ions to Bi0 in the aqueous phase.Also, after the precipitating process, the optical properties of Bi‐NPWs were measured with UV‐Vis spectroscopy, which showed an absorption peak around 290 and 470 nm, characteristic of the plasmonic response of Bi nanoparticles (Bi‐NPs). X‐ray diffraction (XRD) analysis have revealed a rhombohedral polycrystalline structure with a preferential orientation along the (012) plane for the Bi‐NPs. The surface states of the Bi‐NPs were evidenced by X‐ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR).The plasmonic properties the Bi‐NPWs was evaluated and exploited to photo‐stabilization of 2‐Aminophenol (2AP) in aqueous solutions under UV irradiation (365 nm). It was found that the Bi‐NPWs exhibited a remarkablephoto‐stabilization performance depending on the active surface.In the absence of Bi‐NPWs, a significant variation which increases to about (0.42 %) after 9 h of UV irradiation was noticed, with the presence of 6
and 45
Bi‐NPs the relative variation decreases to about (0.12 %) and to about 0.2 % respectively.
Small Organic Molecules with Anchoring Adsorption Enhance Corrosion Inhibition of Zinc Electrodes in ZnSO4 Medium
Authors: Liu Huining , Guan Yin , Wu Yutong , Wang Dexi , Xu Ge 
Published: June 2024

AbstractIn this study, trimercapto‐S‐triazine trisodium salt (TMT) with threefold rotational symmetry as a corrosion inhibitor was introduced into 2 mol ⋅ L−1 ZnSO4 medium. By electrochemical measurements, the corrosion inhibition efficiency of the zinc electrodes was 92.52 % when the concentration of TMT corrosion inhibitor was 2 mmol ⋅ L−1. Based on the microstructural characterization and theoretical analysis of Zn electrodes, it was confirmed that S and N atoms of TMT corrosion inhibitor serve as alternately zinc‐philic adsorption sites with sixfold rotational symmetry for the formation of intermolecular complexes. Adsorption energies of TMT on Zn surfaces were calculated and indicated that the bonds of Zn−N and Zn−S promoted anchoring adsorption on sixfold symmetric (002) plane of zinc. Meanwhile, TMT corrosion inhibitor can adsorb Zn2+ from the electrolyte and directionally deposit them on the surface of Zn (002), effectively avoiding the occurrence of dendrites. This study changes the common knowledge that organic corrosion inhibitors must form hydrophobic films to have corrosion inhibition performance, and provides a new approach for using small organic molecules with anchoring adsorption as metal corrosion inhibitors.
Iron‐Catalyzed Site‐Selective α‐C−H Functionalization in N‐Benzyl Tetrahydroisoquinolines: Enabling Tertiary Amine Transformations
Authors: Nath Priyanka , Rahman Iftakur , Deb Mohit L. , Baruah Pranjal K. 
Published: June 2024

AbstractThis article presents a catalytic approach for site‐selective α‐C−H functionalization of N‐benzyl tetrahydroisoquinolines, which are important tertiary amine derivatives. Using iron salt as a catalyst, we have selectively functionalized carbon‐hydrogen bonds of tertiary amine molecules with diverse moieties, such as imidazopyridine, indoles, and phenylacetylenes. The method offers a broad substrate scope and excellent functional group tolerance, making it a valuable tool for the synthesis of complex molecules. A mechanism is also proposed based on control experiments, which explains the probable reason for selectivity. This iron‐catalyzed C−H functionalization represents a significant advancement in the field of organic synthesis, showcasing the potential of iron catalysis for the construction of valuable chemical motifs.
Functionalized Zr‐MOFs for Enhancing Flame Retardancy and Smoke Suppression Performance on TPU
Authors: Yao Qi , Li Shaoquan , Ban Jianfeng , Yang Bo , Xu Tiwen , Ren Hegang , Huang Yuxin 
Published: June 2024

AbstractMetal‐Organic Framework (MOF) materials can be used as flame‐retardants and smoke suppressants for polymers. As a MOF material, UIO‐66(Zr) possesses higher thermal stability and controllable pore size. In this paper, UIO‐66(Zr), NH2‐UIO‐66(Zr), and SiO2, MWCNT, and GO functionalized NH2‐UIO‐66(Zr) was fabricated to improve the flame retardant and smoke suppression performance of thermoplastic polyurethanes (TPU). The experimental results show that compared with neat TPU (LOI value 19.1 %), 2 % usage of UIO‐66(Zr) and NH2‐UIO‐66(Zr) can endow TPU with 26 % LOI value and vertical combustion rating of V‐1. Moreover, SiO2, MWCNT, and GO functionalized NH2‐UIO‐66(Zr) provide TPU with above 27.8 % LOI value and vertical combustion rating of V‐0. Meanwhile, the CCT results showed that the peak heat release rate and total heat release of TPU‐U5 (added 2 % GO‐modified NH2‐UIO‐66(Zr)) are 299.52 Kw ⋅ m−2 and 68.21 MJ m−2, much lower than that of neat TPU, which are 1180.05 Kw ⋅ m−2and 104.87 MJ m−2, respectively. The TGA, char residue EDS and XRD analysis show that SiO2, MWCNT, and GO functionalized NH2‐UIO‐66(Zr) could generate zirconium metal oxide during the combustion process, which acts as a physical barrier to prevent the TPU matrix by promoting the generation of carbonization layer. The zirconium metal oxide and carbonization layer also can confine flammable gases, which can delay the ignition time and hinder the overflow of gas. In addition, NH2‐UIO‐66(Zr) could generate non‐flammable N2 diluting the concentration of flammable gases. The mechanical properties of TPU composites can maintain more than 87 % of the neat TPU after the addition of 2 % SiO2, MWCNT, and GO functionalized NH2‐UIO‐66(Zr). These results indicate that functionalized Zr‐MOFs composites could act as excellent flame‐retardants in TPU.
Phosphatase Alkaline Inhibition and Antithyroid Activity of Acetylacetone Sulfonamide Derived Schiff Base. In Vitro and In Silico Studies
Authors: Gaddi Gisela M. , Caro‐Ramírez Janetsi Y. , Antonena Yamila B. , Franca Carlos A. , Heredia Leandro Martínez , Lavecchia Martín , Williams Patricia A. M. , Ferrer Evelina G. 
Published: June 2024

AbstractThe sulfonamide‐derived compounds have demonstrated various pharmaceutical properties. However, the exploration of certain properties, such as phosphatase inhibition and anti‐thyroid activities, has been limited in the existing literature. The present study aimed to investigate these specific activities for the Schiff base (Z)‐4‐(4‐oxopent‐2‐en‐2‐ylamino)benzenesulfonamide. The compound underwent thorough physicochemical characterization, including FTIR, Raman, and UV‐Vis spectroscopy, along with theoretical DFT calculations. It exhibited inhibitory activity against intestinal alkaline phosphatase, showing an IC50 value of 37.0±1.0 μM, with kinetic studies indicating a mixed mode of inhibition. Additional insights into the inhibition process were gained through fluorescence spectroscopy and molecular docking studies. The potential anti‐thyroid activity was explored through charge‐transfer studies with iodine, revealing a strong interaction (Kc=2.16±0.05×104 M−1), suggesting a role in reducing the iodination process of triiodothyronine (T3) and thyroxine (T4). Moreover, the compound showed strong, spontaneous, and reversible binding to albumin, indicating potential pharmaceutical relevance. ADME properties were also calculated, confirming favorable drug‐likeness. This study provides valuable insights into the multifaceted pharmaceutical properties of the investigated sulfonamide‐derived compound, encouraging further exploration of its therapeutic potential.
Organo Mediated Sustainable Synthesis and In‐Silico Studies of Novel Benzisoxazole‐Chromene Acyl Hydrazones as AChE Inhibitors
Authors: Govada Grace Victoria , Bhatt Harshil , Panjacharam Paranimuthu , Pal Sanjivani , Kumar Sanjit , Lin Chun‐Cheng , Rajasekhara Reddy Sabbasani 
Published: June 2024

AbstractA new class of benzisoxazole‐Chromene (BC) analogues containing acyl hydrazones BCA (5a‐5m) were obtained by the condensation of different benzo hydrazides with BCs in good yield. All the synthesized BCA analogues were evaluated for their in‐silico activity against Acetylcholine Esterase (AChE). According to docking experiments, the co‐crystallized ligand was outperformed by derivatives 5e (4‐benzisoxazole‐chromene‐3‐(4hydroxyphenyl) acrylohydrazide), 5m (7‐chloro,4‐hydroxy) and 5l (8‐methyl, m‐nitro) showed superior binding modes and binding free energies whereas compound 5j (8‐methyl, 4‐hydroxy) showed appropriate binding energy. These moieties containing acyl hydrazone has shown 4‐fold increase in the binding interactions and orientation. According to ADMET and toxicity studies, derivatives 5e, 5m, 5j, and 5l had the potential to be drugs and have proven to be safe when evaluated using seven toxicity models. Further on checking selectivity with the other cholinesterase enzyme, 5l came out to be selective towards AChE whereas 5e & 5j were acting on another target as well. Finally, DFT analysis validated the binding of the derivatives towards AChE and moreover Molecular Dynamic investigation revealed that 5l is the most capable candidate to interact with the target receptor by comparing its molecular orbital energies, molecular electrostatic potential maps, and ligand movement against the co‐crystallized Ligand.
Development of Gold Nanoparticle based Colorimetric Monkeypox Biosensors Suitable for Point of Care (POC) Analysis
Authors: Perk Benay , Can Goksu , Tepeli Büyüksünetçi Yudum , Ekrem Çitil Burak , Anık Ülkü 
Published: June 2024

AbstractPractical colorimetric biosensors were developed for the detections of A29 and A27L proteins which were defined as Monkeypox virus (MPXV) and smallpox target proteins. For this purpose, gold nanoparticles (AuNPs) were synthesized and used to detect specific interaction between heparan sulphate (HS) receptor and A29 or A27L target proteins. This study is the first colorimetric biosensor that was based on the interaction of HS and A29 or A27L protein. In this work first, HS was labeled with AuNPs. When AuNPs labeled HS was incubated with A29 or A27L protein structure, these proteins specifically bounded to HS. Next, obtained AuNP/HS‐A29 or AuNP/HS‐A27L structures began to aggregate, and then difference in absorbance value of AuNP at 530 nm occurred. Absorbance differences at 530 nm were monitored spectroscopically. After experimental parameters were optimized, analytical characteristics of developed biosensors were investigated. As a result, the limit of detection was calculated as 7.93 ng.mL−1 and 6.09 ng.mL−1for A29 protein and A27L, respectively. The relative standard deviation were calculated as 1.97 % and 5.72 % for 25 ng.mL−1 A29 and 12.5 ng.mL−1 A27, respectively. Sample application studies were also performed with the standard addition of A29 and A27L proteins to real serum samples taken from healthy individuals. As a result, very promising results were obtained.
Microwave‐Assisted Synthesis of Fluorinated 5‐Membered Nitrogen Heterocycles
Authors: Prakash Chandra , Singh Ram 
Published: June 2024

AbstractThe fluorinated 5‐membered N‐containing heterocyclic compounds have wide utility in varied fields. The importance of these compounds has encouraged researchers to explore environment‐friendly synthetic techniques for their synthesis. In this context, microwave‐assisted synthesis has proved beneficial for the synthesis of fluorinated 5‐membered N‐heterocycles in an environmentally benign and energy‐efficient manner. Compared to conventional heating, it offers several advantages, including quick heating, short reaction times, higher yields, and fewer side reactions. This article highlights the microwave‐assisted fluorination of 5‐membered N‐heterocyclic compounds along with the synthesis of fluorinated 5‐membered N‐heterocyclic compounds using fluorinated starting materials.
Application of Twin‐Strep Tagging and TurboID Proximity Labeling in Discovery of Microprotein‐protein Interactions
Authors: Chen Jiaqi , Yuan Xuechun , Yang Bingxin , Yao Xueyu , Cheng Jiongjia , Chu Qian 
Published: June 2024

AbstractMicroproteins are a novel class of bioactive polypeptides that are encoded by small open reading frames (smORFs). Emerging evidence has demonstrated that these microproteins possess significant roles and undertake essential regulatory functions in living organisms. Meanwhile, several microproteins exhibit variable expression and distinct regulation in disease and healthy cells, revealing potential therapeutic interventions. A promising strategy to characterize microproteins and investigate their pathological association is through identification of microprotein‐protein interactions (MPIs), emphasizing the value of chemical biology tools for mapping MPIs. In this study, we applied twin‐strep tagging and TurboID proximity labeling strategies to unveil complicated cellular networks for microproteins. Encouraged by the success of both approaches in identifying the well‐studied CYREN‐Ku70/Ku80 complex, we investigated an uncharacterized FAM229B microprotein and found that it interacts with the thyroid receptor‐interacting protein 6 (TRIP6) and may regulate its nuclear translocation. Our study demonstrated that twin‐strep tagging and TurboID labeling strategies exhibited encouraging performance in identifying bona fide microprotein interacting partners.
Silver(I)‐Catalyzed Highly para‐Selective Phosphonation of 2‐Arylbenzo[d]thiazoles
Authors: Cui Peng‐Cheng , Wang Guan‐Wu 
Published: June 2024

AbstractA method for the silver(I)‐catalyzed phosphonation of electron‐deficient 2‐arylbenzo[d]thiazoles has been developed. This strategy is highly regioselective for obtaining para‐selective phosphonation products by cross‐dehydrogenation coupling with good functional group tolerance and requires no prefunctionalization. This facile approach provides a practical route for synthesizing arylphosphine oxides. Mechanistic studies show that the para‐phosphonation occurs via a radical process.
Unraveling the puzzling risk–return relationship: Distinctive roles of government involvement in venture capital investment
Authors: Zhang Jiamin , Gu Qian Cecilia 
Published: June 2024

AbstractResearch SummaryGovernment involvement plays a significant role in fostering entrepreneurship. We examine how government involvement in venture capital (VC) investments shapes the decoupling between risk‐taking and investment returns. We distinguish government involvement through state ownership (GVC) and personal political connections (connected VC). We theorize that government involvement through GVC is associated with the downside risk–return paradox, that is, concurrent higher risk‐taking and lower‐than‐expected returns. In contrast, government involvement through connected VCs is linked to the upside risk–return paradox, that is, concurrent lower risk‐taking and higher‐than‐expected returns. Our theoretical predictions receive general support from analyses using longitudinal data from VC firms in China. Our study sheds light on the heterogeneity in the decoupling between risk and return and the underlying mechanisms through which governments influence entrepreneurship.Managerial SummaryGovernments often seek to promote entrepreneurship; yet, their involvement in start‐ups tends to deviate from the conventional wisdom of a positive risk–return association. Government‐owned venture capital (VC) firms tend to take greater risks and invest in earlier‐stage start‐ups, but yield lower returns from their investments. Conversely, VC firms that have personal ties to government officials tend to take lower risks and prefer later‐stage start‐ups, yet achieve higher returns. These intriguing findings reveal the complexities of government participation in entrepreneurial activities and offer valuable insights for policy formulation. In addition, our findings highlight the importance for entrepreneurs to recognize diverse goals and resources in government involvement. Considering this when seeking external financing is helpful in positioning start‐ups for growth and success.
Platelet Membrane‐Coated Curcumin‐PLGA Nanoparticles Promote Astrocyte‐Neuron Transdifferentiation for Intracerebral Hemorrhage Treatment
Authors: Xu Ximing , Zhang Xinyu , Li Ran , Yang Xiufen , Fu Peng , Feng Ruijie , Sun Xuan , Wang Zhe , Yu Jiangnan , Cao Xia , Yu Qingtong , Wang Qilong , Liu Sitong , Yang Xiaoxia , Zhu Yuan , Shi Wentao , Deng Wenwen 
Published: June 2024

AbstractIntracerebral hemorrhage (ICH) is a hemorrhagic disease with high mortality and disability rates. Curcumin is a promising drug for ICH treatment due to its multiple biological activities, but its application is limited by its poor watersolubility and instability. Herein, platelet membrane‐coated curcumin polylactic‐co‐glycolic acid (PLGA) nanoparticles (PCNPs) are prepared to achieve significantly improved solubility, stability, and sustained release of curcumin. Fourier transform infrared spectra and X‐ray diffraction assays indicate good encapsulation of curcumin within nanoparticles. Moreover, it is revealed for the first time that curcumin‐loaded nanoparticles can not only suppress hemin‐induced astrocyte proliferation but also induce astrocytes into neuron‐like cells in vitro. PCNPs are used to treat rat ICH by tail vein injection, using in situ administration as control. The results show that PCNPs are more effective than curcumin‐PLGA nanoparticles in concentrating on hemorrhagic lesions, inhibiting inflammation, suppressing astrogliosis, promoting neurogenesis, and improving motor functions. The treatment efficacy of intravenously administered PCNPs is comparable to that of in situ administration, indicating a good targeting effect of PCNPs on the hemorrhage site. This study provides a potent treatment for hemorrhagic injuries and a promising solution for efficient delivery of water‐insoluble drugs using composite materials of macromolecules and cell membranes.
In Situ Polymerization Bi‐Functional Gel Polymer Electrolyte for High Performance Quasi‐Solid‐State Lithium−Sulfur Batteries
Authors: Hu Liuyi , Yang Tianqi , Zhou Luoting , Yan Xiang , Liu Yaning , Xia Yang , Zhang Wenkui , Zhang Jun , Gan Yongping , He Xinping , Xia Xinhui , Fang Ruyi , Tao Xinyong , Huang Hui 
Published: June 2024

AbstractLithium–sulfur (Li–S) batteries are expected to be the next‐generation energy storage system due to the ultrahigh theoretical energy density and low cost. However, the notorious shuttle effect of higher‐order polysulfides and the uncontrollable lithium dendrite growth are the two biggest challenges for commercially viable Li–S batteries. Herein, these two main challenges are solved by in situ polymerization of bi‐functional gel polymer electrolyte (GPE). The initiator (SiCl4) not only drives the polymerization of 1,3‐dioxolane (DOL) but also induces the construction of a hybrid solid electrolyte interphase (SEI) with inorganic‐rich compositions on the Li anode. In addition, diatomaceous earth (DE) is added and anchored in the GPE to obtain PDOL‐SiCl4‐DE electrolyte through in situ polymerization. Combined with density functional theory (DFT) calculations, the hybrid SEI provides abundant adsorption sites for the deposition of Li+, inhibiting the growth of lithium dendrites. Meanwhile, the shuttle effect is greatly alleviated due to the strong adsorption capacity of DE toward lithium polysulfides. Therefore, the Li/Li symmetric cell and Li–S full cell assembled with PDOL‐SiCl4‐DE exhibit excellent cycling stability. This study offers a valuable reference for the development of high performance and safe Li–S batteries.
Factors affecting architectural decision‐making process and challenges in software projects: An industrial survey
Authors: Demir Merve Özdeş , Chouseinoglou Oumout , Tarhan Ayça Kolukısa 
Published: June 2024

AbstractSoftware architecture plays a fundamental role in overcoming the challenges of the development process of large‐scale and complex software systems. The software architecture of a system is the result of an extensive process in which several stakeholders negotiate issues and solutions, and as a result of this negotiation, a series of architectural decisions are made. This survey study aims to determine the experiences of the software industry experts with respect to architectural decision‐making, the factors that are effective in decision‐making, and the technical and social problems they encounter. An online questionnaire‐based survey was conducted with 101 practitioners. The responses were analyzed qualitatively and quantitatively. Analysis of responses revealed that the majority of the participants prefer to document some or all of the architectural decisions taken and to store these documents in web‐based collaboration software. Decisions are usually made by teams of two or three, and discussion‐based approaches (brainstorming and consensus) are adopted. In the software architecture decision‐making process, “major business impact” is the most challenging situation. Information sharing and keeping track of decisions and decision rationale are areas in need of improvement as identified by most participants. From the participants' feedback and their answers to open‐ended questions, we concluded that the software architecture decision‐making process has an important role in the industry. Our key findings are that decisions made in the architectural decision‐making process are taken by teams and generally all decisions are documented. In projects where decisions are made by a single person, peer pressure is found to be significantly different from pressure in projects where decisions are made by the group. This is an indication that as the number of people in the decision‐making process increases, the disagreements also increase.
Bridging‐Solvent Strategy for Quasi‐Single‐Crystal Perovskite Films and Stable Solar Cells
Authors: Zhang Yao , Sun Xiangyu , Guan Zhen , Li Dongni , Wang Qingya , Yue Yansong , Liu Fangze , Wei Jing , Li Hongbo 
Published: June 2024

AbstractControllable fabrication of formamidinium (FA)‐based perovskite solar cells (PSCs) with both high efficiency and long‐term stability is the key to their further commercialization. However, the diversity of PbI2 complexes and perovskite compositions usually leads to light sensitive PbI2 residues and phase impurities in the film, which can accelerate the device degradation. Here, the crystallization kinetics of FA‐based perovskite films are studied and a bridging‐solvent strategy is proposed to modulate the reaction kinetics between PbI2 and ammonium salts by prohibiting the formation of undesired intermediates. N‐methylpyrrolidone (NMP) solvent is introduced into the PbI2 precursor solution to obtain stable and homogeneous PbI2‐NMP complex films. The strong interaction between NMP and formamidinium iodide (FAI) molecules promotes the conversion from PbI2‐NMP into (001)‐oriented quasi‐single‐crystal perovskite films with negligible impurities, long carrier lifetime of 1.5 µs and a large grain size of 3 µm. The optimized PSCs exhibit a high power conversion efficiency of 24.1%, as well as superior shelf stability which maintains 95% initial efficiency after storage in air for 1200 h (T95 = 1200 h), and operating stability with T96 = 300 h under continuous working at the maximum power point. This work offers a simple and reproducible method for fabricating phase‐pure and uniaxially oriented perovskite films.