bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variabilité inter- et intra‑individuelle des stratégies de réalisation d'une tâche d'assemblage assistée par un document multimédia
Authors: Houard Olivier , Bellet L. , Vom Hofe Alain 
Published: May 2012

Résumé Cette recherche empirique vise à montrer l’intérêt que peut présenter, pour l’analyse d’une tâche procédurale assistée par une notice multimédia, l’étude des stratégies mises en œuvre par les utilisateurs. Abordées à l’échelle de la variabilité intra‑individuelle dans le cours de la tâche, et selon les influences de facteurs internes (niveau d’aptitude spatiale des participants) et de facteurs externes (formats de présentation multimédia « pop‑up » vs classique), les stratégies apparaissent à la fois pertinentes au regard de l’activité et suffisamment prédictibles pour qu’elles soient exploitées comme descripteurs aussi bien dans les taxonomies de tâches que dans la spécification de solutions ergonomiques centrées‑utilisateurs.
Les comportements pro- et antisociaux au travail : une recherche exploratoire testant deux échelles de mesure et leurs liens avec des inducteurs organisationnels et individuels
Authors: Desrumaux Pascale , Léoni Véronique , Bernaud Jean-Luc , Defrancq C. 
Published: May 2012

Résumé Les recherches sur les comportements antisociaux au travail ( caat ) sont nombreuses et permettent de distinguer les comportements anti‑organisationnels et anti‑individuels (Bennett & Robinson, 2000 ; Berry et al. , 2007 ; Courcy, et al. , 2004 ; Gruys & Sackett, 2003 ; Hershcovis et al., 2007). La même distinction pourrait être opérée pour les comportements prosociaux (Bierhoff, 2002 ; Podsakoff et al. , 2000) qui ont été moins étudiés. Dans le but de comprendre les inducteurs de ces deux catégories de comportements, notre recherche a deux objectifs. Le premier est exploratoire et vise à développer une démarche nomologique afin de valider une première version de deux échelles, l’une de comportements prosociaux et l’autre de comportements antisociaux. Le second objectif, dans la lignée du modèle de Leblanc et al. (2004), consiste à étudier les liens entre des variables de l’organisation (justice, engagement au travail) et personnologiques (personnalité, satisfaction) non seulement avec les comportements antisociaux au travail ( caat ) mais aussi avec les comportements prosociaux au travail ( cpst ). Un questionnaire de 205 questions a été soumis à 256 salariés du Nord-Pas-de-Calais. Deux analyses des données sur les comportements pro- puis antisociaux ont validé deux échelles comprenant chacune une structure factorielle en 4 dimensions. La première analyse relative aux comportements prosociaux met en évidence quatre facteurs : F1 : Mobilisation‑Dynamisation‑Autonomisation, F2 : Prosocialité de propriété, F3 : Prosocialité de Production/Politique, F4 : Aide. Une opposition entre F1 (comportements pro‑individuels) et F2 (comportements pro‑organisationnels) a été trouvée. La prosocialité de propriété occupe une place centrale dans le facteur 2 et les prosocialités de production et de propriété saturent F3. L’analyse relative aux comportements antisociaux au travail produit quatre facteurs : F1 : Agression, F2 : Déviances de Production et de Propriété, F3 : Déviance de propriété, F4 : Déviance politique. L’opposition F1/F2 (organisation/individus) pertinente pour les comportements antisociaux est retrouvée et justifie l’idée d’une classification distincte en fonction des cibles (organisation/individu) dans les champs de l’anti et de la prosocialité. Ensuite, les analyses de régression ont mis en évidence les liens entre d’une part, les comportements prosociaux et d’autre part, les différentes formes d’engagement et la justice procédurale. De leur côté, les caat sont expliqués par les différentes formes de justice organisationnelle et l’extraversion.
Accessibilité pour et dans l'usage : concevoir des situations d'activité adaptées à tous et à chacun
Authors: Folcher Viviane , Lompré Nicole 
Published: May 2012

Résumé L’accessibilité consiste à offrir les mêmes droits et chances et permettre la pleine participation de tous à la société. Question sociale de portée générale, l’accessibilité fait l’objet d’un cadre réglementaire qui couvre l’ensemble des activités humaines : emploi, conditions de travail, accès et circulation dans les cadres bâtis, transports, usage de ressources en ligne, éducation et formation. Les multiples textes de loi et directives, les règlementations et normes techniques spécifient de façon disjointe les caractéristiques souhaitables des environnements (cadre bâti, transports, espaces publics, nouvelles technologies...). En conséquence, alors que l’accessibilité est porteuse d’une démarche universelle d’inclusion de tous à la société, elle se concrétise dans une juxtaposition d’actions de façon fragmentaire. Transversale aux différents domaines d’activité humaine et adressée à la diversité et la dynamique évolutive des personnes, l’accessibilité peut être appréhendée en ergonomie dans une démarche systémique accordant le primat à l’intrinsèque et visant la contribution à la conception d’environnement accessible à tous et à chacun. Nous débutons par une définition de l’accessibilité et exposons les raisons pour lesquelles ce problème de société intéresse l’ergonomie. Nous présentons ensuite les évolutions politiques législatives qui ont eu cours dans les champs du handicap et de l’accessibilité ces dernières décennies. Enfin, nous positionnons notre contribution au problème de l’accessibilité dans les termes de la conception de situations d’activité adaptées à tous et à chacun qui se réalise dans la rencontre entre l’accessibilité‑pour‑l’usage et l’accessibilité‑dans‑l’usage. Prenant appui sur les nombreuses contributions en ergonomie et en psychologie, nous articulons notre proposition aux apports historiques dans lesquels elle puise.
Haute et basse police selon Jean-Paul Brodeur
Authors: Manning Peter K. 
Published: May 2012

Cet article se divise en trois parties. La première partie procède à une lecture détaillée de « High policing and low policing… », l’article en anglais le plus influent de Jean-Paul Brodeur qui formula en 1983 les concepts de haute et de basse police. Cette discussion tient compte de la version plus détaillée de ce cadre théorique qui est contenue dans The Policing Web, son dernier livre. La deuxième partie examine la prescience de l’article sur la haute et la basse police, qui anticipa les développements actuels dont le rythme s’est accéléré depuis les attentats du 11 septembre. La troisième partie se penche sur l’importance d’inclure la haute police dans une théorie émergente du policing.
Jean-Paul Brodeur on High and Low Policing
Authors: Manning Peter K. 
Published: May 2012

Cet article se divise en trois parties. La première partie procède à une lecture détaillée de « High policing and low policing… », l’article en anglais le plus influent de Jean-Paul Brodeur qui formula en 1983 les concepts de haute et de basse police. Cette discussion tient compte de la version plus détaillée de ce cadre théorique qui est contenue dans The Policing Web, son dernier livre. La deuxième partie examine la prescience de l’article sur la haute et la basse police, qui anticipa les développements actuels dont le rythme s’est accéléré depuis les attentats du 11 septembre. La troisième partie se penche sur l’importance d’inclure la haute police dans une théorie émergente du policing.
Kv1.3 Deletion Biases T Cells toward an Immunoregulatory Phenotype and Renders Mice Resistant to Autoimmune Encephalomyelitis
Authors: Gocke Anne R. , Lebson Lori A. , Grishkan Inna V. , Hu Lina , Nguyen Hai M. , Whartenby Katharine A. , Chandy K. George , Calabresi Peter A. 
Published: May 2012

Abstract
Increasing evidence suggests ion channels have critical functions in the differentiation and plasticity of T cells. Kv1.3, a voltage-gated K+ channel, is a functional marker and a pharmacological target for activated effector memory T cells. Selective Kv1.3 blockers have been shown to inhibit proliferation and cytokine production by human and rat effector memory T cells. We used Kv1.3 knockout (KO) mice to investigate the mechanism by which Kv1.3 blockade affects CD4+ T cell differentiation during an inflammatory immune-mediated disease. Kv1.3 KO animals displayed significantly lower incidence and severity of myelin oligodendrocyte glycoprotein (MOG) peptide-induced experimental autoimmune encephalomyelitis. Kv1.3 was the only KV channel expressed in MOG 35–55-specific CD4+ T cell blasts, and no KV current was present in MOG-specific CD4+ T cell-blasts from Kv1.3 KO mice. Fewer CD4+ T cells migrated to the CNS in Kv1.3 KO mice following disease induction, and Ag-specific proliferation of CD4+ T cells from these mice was impaired with a corresponding cell-cycle delay. Kv1.3 was required for optimal expression of IFN-γ and IL-17, whereas its absence led to increased IL-10 production. Dendritic cells from Kv1.3 KO mice fully activated wild-type CD4+ T cells, indicating a T cell-intrinsic defect in Kv1.3 KO mice. The loss of Kv1.3 led to a suppressive phenotype, which may contribute to the mechanism by which deletion of Kv1.3 produces an immunotherapeutic effect. Skewing of CD4+ T cell differentiation toward Ag-specific regulatory T cells by pharmacological blockade or genetic suppression of Kv1.3 might be beneficial for therapy of immune-mediated diseases such as multiple sclerosis.
Negative Feedback Regulation of Antigen Receptors through Calmodulin Inhibition of E2A
Authors: Verma-Gaur Jiyoti , Hauser Jannek , Grundström Thomas 
Published: May 2012

Abstract
Signaling from the BCR is used to judge Ag-binding strengths of the Abs of B cells. BCR signaling enables the selection for successive improvements in the Ag affinity over an extremely broad range of affinities during somatic hypermutation. We show that the mouse BCR is subject to general negative feedback regulation of the receptor proteins, as well as many coreceptors and proteins in signal pathways from the receptor. Thus, the BCR can downregulate itself, which can enable sensitive detection of successive improvements in the Ag affinity over a very large span of affinities. Furthermore, the feedback inhibition of the BCR signalosome and most of its proteins, as well as most other regulations of genes by BCR stimulation, is to a large extent through inhibition of the transcription factor E2A by Ca2+/calmodulin.
L-Plastin Regulates Polarization and Migration in Chemokine-Stimulated Human T Lymphocytes
Authors: Freeley Michael , O’Dowd Francis , Paul Toby , Kashanin Dmitry , Davies Anthony , Kelleher Dermot , Long Aideen 
Published: May 2012

Abstract
Chemokines such as SDF-1α play a crucial role in orchestrating T lymphocyte polarity and migration via polymerization and reorganization of the F-actin cytoskeleton, but the role of actin-associated proteins in this process is not well characterized. In this study, we have investigated a role for L-plastin, a leukocyte-specific F-actin–bundling protein, in SDF-1α–stimulated human T lymphocyte polarization and migration. We found that L-plastin colocalized with F-actin at the leading edge of SDF-1α–stimulated T lymphocytes and was also phosphorylated at Ser5, a site that when phosphorylated regulates the ability of L-plastin to bundle F-actin. L-plastin phosphorylation was sensitive to pharmacological inhibitors of protein kinase C (PKC), and several PKC isoforms colocalized with L-plastin at the leading edge of SDF-1α–stimulated lymphocytes. However, PKC ζ, an established regulator of cell polarity, was the only isoform that regulated L-plastin phosphorylation. Knockdown of L-plastin expression with small interfering RNAs demonstrated that this protein regulated the localization of F-actin at the leading edge of chemokine-stimulated cells and was also required for polarization, lamellipodia formation, and chemotaxis. Knockdown of L-plastin expression also impaired the Rac1 activation cycle and Akt phosphorylation in response to SDF-1α stimulation. Furthermore, L-plastin also regulated SDF-1α–mediated lymphocyte migration on the integrin ligand ICAM-1 by influencing velocity and persistence, but in a manner that was independent of LFA-1 integrin activation or adhesion. This study, therefore, demonstrates an important role for L-plastin and the signaling pathways that regulate its phosphorylation in response to chemokines and adds L-plastin to a growing list of proteins implicated in T lymphocyte polarity and migration.
EVI1 Acts as an Inducible Negative-Feedback Regulator of NF-κB by Inhibiting p65 Acetylation
Authors: Xu Xiangbin , Woo Chang-Hoon , Steere Rachel R. , Lee Byung Cheol , Huang Yuxian , Wu Jing , Pang Jinjiang , Lim Jae Hyang , Xu Haidong , Zhang Wenhong , Konduru Anuhya S. , Yan Chen , Cheeseman Michael T. , Brown Steve D. M. , Li Jian-Dong 
Published: May 2012

Abstract
Inflammation is a hallmark of many important human diseases. Appropriate inflammation is critical for host defense; however, an overactive response is detrimental to the host. Thus, inflammation must be tightly regulated. The molecular mechanisms underlying the tight regulation of inflammation remain largely unknown. Ecotropic viral integration site 1 (EVI1), a proto-oncogene and zinc finger transcription factor, plays important roles in normal development and leukemogenesis. However, its role in regulating NF-κB–dependent inflammation remains unknown. In this article, we show that EVI1 negatively regulates nontypeable Haemophilus influenzae- and TNF-α–induced NF-κB–dependent inflammation in vitro and in vivo. EVI1 directly binds to the NF-κB p65 subunit and inhibits its acetylation at lysine 310, thereby inhibiting its DNA-binding activity. Moreover, expression of EVI1 itself is induced by nontypeable Haemophilus influenzae and TNF-α in an NF-κB–dependent manner, thereby unveiling a novel inducible negative feedback loop to tightly control NF-κB–dependent inflammation. Thus, our study provides important insights into the novel role for EVI1 in negatively regulating NF-κB–dependent inflammation, and it may also shed light on the future development of novel anti-inflammatory strategies.
Leukemia Inhibitory Factor Signaling Is Required for Lung Protection during Pneumonia
Authors: Quinton Lee J. , Mizgerd Joseph P. , Hilliard Kristie L. , Jones Matthew R. , Kwon Candice Y. , Allen Eri 
Published: May 2012

AbstractLung infections represent a tremendous disease burden and a leading cause of acute lung injury. STAT3 signaling is essential for controlling lung injury during pneumonia. We previously identified LIF as a prominent STAT3-activating cytokine expressed in the airspaces of pneumonic lungs, but its physiological significance in this setting has never been explored. To do so, Escherichia coli was intratracheally instilled into C57BL/6 mice in the presence of neutralizing anti-LIF IgG or control IgG. Anti-LIF completely eliminated lung LIF detection and markedly exacerbated lung injury compared with control mice as evidenced by airspace albumin content, lung liquid accumulation, and histological analysis. Although lung bacteriology was equivalent between groups, bacteremia was more prevalent with anti-LIF treatment, suggestive of compromised barrier function rather than impaired antibacterial defense as the cause of dissemination. Inflammatory cytokine expression was also exaggerated in anti-LIF–treated lungs, albeit after injury had ensued. Interestingly, alveolar neutrophil recruitment was modestly but significantly reduced compared with control mice despite elevated cytokine levels, indicating that inflammatory injury was not a consequence of excessive neutrophilic alveolitis. Lastly, the lung transcriptome was dramatically remodeled during pneumonia, but far more so following LIF neutralization, with gene changes implicating cell death and epithelial homeostasis among other processes relevant to tissue injury. From these findings, we conclude that endogenous LIF facilitates tissue protection during pneumonia. The LIF–STAT3 axis is identified in this study as a critical determinant of lung injury with clinical implications for pneumonia patients.
HIV-1 Capture and Antigen Presentation by Dendritic Cells: Enhanced Viral Capture Does Not Correlate with Better T Cell Activation
Authors: Rodriguez-Plata Maria T. , Urrutia Alejandra , Cardinaud Sylvain , Buzón Maria J. , Izquierdo-Useros Nuria , Prado Julia G. , Puertas Maria C. , Erkizia Itziar , Coulon Pierre-Grégoire , Cedeño Samandhy , Clotet Bonaventura , Moris Arnaud , Martinez-Picado Javier 
Published: May 2012

Abstract
During HIV-1 infection, dendritic cells (DC) facilitate dissemination of HIV-1 while trying to trigger adaptive antiviral immune responses. We examined whether increased HIV-1 capture in DC matured with LPS results in more efficient Ag presentation to HIV-1–specific CD4+ and CD8+ T cells. To block the DC-mediated trans-infection of HIV-1 and maximize Ag loading, we also evaluated a noninfectious integrase-deficient HIV-1 isolate, HIVNL4-3ΔIN. We showed that higher viral capture of DC did not guarantee better Ag presentation or T cell activation. Greater HIVNL4-3 uptake by fully LPS-matured DC resulted in higher viral transmission to target cells but poorer stimulation of HIV-1–specific CD4+ and CD8+ T cells. Conversely, maturation of DC with LPS during, but not before, viral loading enhanced both HLA-I and HLA-II HIV-1–derived Ag presentation. In contrast, DC maturation with the clinical-grade mixture consisting of IL-1β, TNF-α, IL-6, and PGE2 during viral uptake only stimulated HIV-1–specific CD8+ T cells. Hence, DC maturation state, activation stimulus, and time lag between DC maturation and Ag loading impact HIV-1 capture and virus Ag presentation. Our results demonstrate a dissociation between the capacity to capture HIV-1 and to present viral Ags. Integrase-deficient HIVNL4-3ΔIN was also efficiently captured and presented by DC through the HLA-I and HLA-II pathways but in the absence of viral dissemination. HIVNL4-3ΔIN seems to be an attractive candidate to be explored. These results provide new insights into DC biology and have implications in the optimization of DC-based immunotherapy against HIV-1 infection.
Copper‐Catalyzed Coupling of (E)‐Bromostilbene with Phenols/Azole: ESI‐MS Detection of Intermediates by Using an Ionically‐Tagged Ligand
Authors: Limberger Jones , Leal Bárbara C. , Back Davi F. , Dupont Jairton , Monteiro Adriano L. 
Published: May 2012

AbstractA system based on copper/1,10‐phenanthroline efficiently promotes the coupling between phenols or pyrazole with (E)‐bromostilbene. (E)‐1‐Aryloxy‐1,2‐diphenylethenes were obtained from the coupling with phenols in good to excellent yields (69–90%). The exception was the reaction involving a phenol containing an electron‐withdrawing cyano group that required a longer reaction time and gave only 49% yield. Kinetic studies indicated the participation of the vinyl halide in the rate‐determining step. Under the conditions employed, the activation of the vinyl halide via a radical pathway was discarded using a radical scavenger test. By using an ionically‐tagged 1,10‐phenanthroline derivative as the ligand, various copper‐based ions were detected through ESI(+)‐MS. These ions suggested that formation of the active species [phenCuOAr(HOAr)2] precedes the vinyl halide activation.
Regioselective Enzymatic Acylation of Aureolic Acids to Obtain Novel Analogues with Improved Antitumor Activity
Authors: González‐Sabín Javier , Núñez Luz Elena , Braña Alfredo F. , Méndez Carmen , Salas José A. , Gotor Vicente , Morís Francisco 
Published: May 2012

AbstractA variety of aureolic acids was efficiently obtained by lipase‐catalyzed regioselective acylation reactions of mithramycin and its analogues mithramycin SK and mithramycin SDK. The acylation took place in the aglycone moiety or in the B sugar unit, depending on the substrate, lipase and acyl donor considered. Most of the novel acylated derivatives showed antitumor activity at double digit nanomolar concentrations, in some cases significantly improving the activity of the parent drugs.
Supersymmetric solution of Schrödinger equation by using the asymptotic iteration method
Authors: Kocak G. , Bayrak O. , Boztosun I. 
Published: May 2012

AbstractIn this work, the exact analytical solutions of the radial Schrödinger equation are presented for the harmonic oscillator, Hulthén and Pöschl‐Teller potentials within the framework of the asymptotic iteration method by using supersymmetry. The energy eigenvalues and the corresponding eigenfunctions are obtained analytically.
Co‐poly(vinyl chloride‐vinyl acetate‐vinyl alcohol)‐silica nanocomposites from sol–gel process: Morphological, mechanical, and thermal investigations
Authors: Nadeem Uzma , Ahmad Zahoor , Zulfiqar Sonia , Sarwar Muhammad Ilyas 
Published: May 2012

AbstractOrganic–inorganic nanocomposites consisting of co‐poly(vinyl chloride‐vinyl acetate‐vinyl alcohol) and silica were prepared via sol–gel process. Two types of hybrids were prepared, one in which interactions between hydroxyl group present in the copolymer chain and silanol groups of silica network were developed. In the second set, extensive chemical bonding between the phases was achieved through the reaction of hydroxyl groups on the copolymer chains with 3‐isocyanatopropyltriethoxysilane (ICTS). Hydrolysis and condensation of tetraethoxysilane and pendant ethoxy groups on the chain yielded inorganic network structure. Mechanical and thermal behaviors of the hybrid films were studied. Increase in Young's modulus, tensile strength, and toughness was observed up to 2.5 wt % silica content relative to the neat copolymer. The system in which ICTS was employed as binding agent, the tensile strength and toughness of hybrid films increased significantly as compared to the pure copolymer. Thermogravimetric analysis showed that these nanocomposite materials were stable up to 250°C. The glass transition temperature increases up to 2.5 wt % addition of silica in both the systems. Field emission scanning electron microscope results revealed uniform distribution of silica in the copolymer matrix. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Rheological and mechanical behavior of LDPE/calcium carbonate nanocomposites and microcomposites
Authors: Mantia Francesco Paolo La , Morreale Marco , Scaffaro Roberto , Tulone Simona 
Published: May 2012

AbstractThe increase of the interest in polymer nanocomposites has been leading to continuous growing search toward nanofillers alternative to the widely known clay‐based ones. One of these possible alternatives is represented by calcium carbonate nanoparticles, which have not been widely investigated in such context. In this article, a study on the rheological and morphological behavior of different low density polyethylene‐calcium carbonate nanocomposites, compared with a reference calcium carbonate microcomposite, is presented. Several different nanosized calcium carbonates at different amounts were used. The results from the rheological and mechanical tests outlined that only minor changes occur when the amount is up to 2 wt %. The use of higher filler concentrations or the increase in the processing time can significantly affect this behavior. SEM analysis allowed deeper understanding of these phenomena. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Synthesis of 3,4‐Dihalogenated Furan‐2‐(5 H)‐ones by Electrophilic Cyclization of 4‐Hydroxy‐2‐alkynoates
Authors: Zhu Hai‐Tao , Wang Li‐Jing , Ji Ke‐Gong , Liu Xue‐Yuan , Liang Yong‐Min 
Published: May 2012

AbstractFunctionalized 3,4‐dihalogenated furan‐2(5 H)‐ones can be readily prepared in moderate to good yields by treating 4‐hydroxy‐4‐arylbut‐2‐ynoate derivatives with ICl, IBr, and I2. Both halogen atoms of the electrophile are incorporated in the product. The resulting halides can further afford polycyclic aromatic compounds using known palladium‐catalyzed coupling reactions.