bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organizational Commitment of Korean American Nurses: A Cross-Sectional Study
Authors: Jun Myunghee , Kim Hye-Kyung , Kim Sungsu , Wreen Michael , Kim Yeon Hee , Vandenhouten Christine , Shin Soo Il 
Published: February 2025

Background: Studies on reducing the turnover of foreign-educated nurses (FENs) can help address the nursing shortage in the United States. Organizational commitment and associated factors have been explored in relation to lower turnover. Nursing researchers have identified job satisfaction, psychological contract breach, person-organization fit, and person-work setting fit as major factors in enhancing nurses’ organizational commitment. Research on the organizational commitment of Korean American (KA) nurses would provide insights into reducing turnover among FENs. Objectives: This study identifies some of the key factors that significantly enhance the organizational commitment of KA nurses. Methods: A cross-sectional study conducted with a survey was employed. One hundred fifty-one KA nurses working in US healthcare organizations participated in the study. Analysis of variance, Pearson correlation, and multiple linear regression analyses were used to identify the key factors associated with nurses’ organizational commitment. Results: Nurses with higher job satisfaction, lower perception of psychological contract breach, and higher perception of person-organization fit display a stronger organizational commitment. Other factors associated with organizational commitment are age and geographical work location. The adjusted R2 of the 5 factors included in the research model is 0.62 ( F[11,139] = 22.78, P = .001). Conclusions: Strategies are needed to enhance job satisfaction and perceived person-organization fit and to reduce psychological contract breach for KA and other FENs. The strategies should include comprehensive training and job-enculturation programs, systematic efforts for clear communication, and attention to respect and fairness for KA and other FENs.
Enhanced mechanical property and thermal insulation of modified rigid polyurethane foams by few surface-functional silica aerogel
Authors: Zhou Xinyu , Li Xiaoyu , Lei Xue , Lian Zhaolong , Ge Chao , Sun Jiuchao , Liu Ningning , Zhao Min , Huang Yudong , Wang Caifeng 
Published: February 2025

Silica aerogel (SA) was functionalized by γ-amino propyl triethoxy silane (APTES) with long chain amino groups, and this surface-functional SA was filled into rigid polyurethane (PU) foams to enhanced mechanical property and thermal insulation. It was proved that the active functional groups and different content of SA (0.3, 0.5, 0.7 and 0.9 wt%) played important roles in controlling cellular structure of PU foams. The results of the scanning electron microscopy (SEM) and water absorption showed that the surface-functionalized SA made the cell uniformly and reduced the number of damage cells. The surface-functionalized SA had a positive effect on the hardness and density of the foams. Moreover, the thermal conductivity of PU foams was reduced by 17.60% and the compressive strength was increased by 43.27% at 0.5 wt% filler of surface-functional SA. The active functional groups (amino groups) of surface-functional SA could take place PU foaming reaction and enhance the interactions and compatibility between SA and matrix. Thus, these foams with small amounts of filler would find vast applications in the thermal insulation sectors.
Evaluation of the analgesic effect of a combination of oral acetaminophen and oxycodone after extracorporeal shock wave lithotripsy (SWL)
Authors: Zareian Baghdadabad Leila , Mohammadi Abdolreza , Menbari Oskouie Iman , Alaeddini Farshid , Farajidavar Hirad , Oliveira Reis Leonardo , Aghamir Seyed Mohammad Kazem 
Published: February 2025

Objective: The present study aimed to compare the effects of suppository diclofenac (an example of NSAIDs) and oral administration of the combination of oxycodone (an example of an opioid) and acetaminophen in managing pain in patients with renal colic after SWL treatment. Method: The current study is a double-blind clinical trial involving individuals scheduled to receive elective SWL therapy for kidney and ureteral stones. Participants were randomly assigned to one of two groups using the block randomization technique: suppository Diclofenac (100 mg) or a combination of 325 mg Acetaminophen + 5 mg oxycodone administered orally for pain relief following SWL. Pain intensity was measured immediately after the SWL procedure, and analgesics were then given to the patients. After 30 min, pain severity was reassessed. The severity of pain in patients was documented before and after drug administration at 24, 48, and 72 h after the SWL intervention. Results: 154 renal stone patients (63 females) underwent SWL with a mean age of 41.52 ± 10.52 years. The two groups were similar in terms of age ( p = 0.572), sex ( p = 0.212), location of the stone ( p = 0.868), size of the stone ( p = 0.762), and occurrence of complication ( p = 0.302). There was no significant difference in the reduction of pain severity between the two groups after 30 min ( p = 0.224), 2 days ( p = 0.501), and 3 days ( p = 0.229) following SWL intervention. However, after a 24-h follow-up, pain severity decreased more in the diclofenac group compared to the other group ( p = 0.002). Conclusion: The combination of oxycodone and acetaminophen, including a multimodal analgesic approach, can be considered a preferred option in the clinical setting for pain management of patients undergoing SWL. It provides relief for patients as effectively as NSAIDs, with the same safety profile, leading to high patient satisfaction.
Baicalin loaded monodispersed polycaprolactone (PCL) microspheres preparation by polyvinylidene fluoride (PVDF) membrane emulsification for wound healing in dermal fibroblasts
Authors: Zhong Wenwei , Cao Xiang , Zeng Haoran , Tang Manqun , Li Guizhen , Xiong Jia , Wang Yunong , Guo Liwei , Ji Jing 
Published: February 2025

The development of injectable bio-stimulating polycaprolactone (PCL) microspheres for wound healing has strict requirement on size and morphology control, particularly favoring microspheres within the range between 20-50 µm. PCL microspheres with smaller sizes are phagocyted at rapid rate while larger microspheres could cause inflammation. Homogenization can be regarded as an irreversible process to generate microspheres of particular size range while it still remains as the most common approach for microspheres production. Membrane emulsification technology shows great potential in fine tailoring of microspheres while still holds promising ability for scale-up production. Membranes with uniform large pores and dual hydrophilicity might be capable of the production of large microspheres via emulsification with tailorable size distribution. The aim of this study is to verify the feasibility of PVDF membranes with large pores on the generation of PCL microspheres via the combined crystallization diffusion (CCD) approach. The effect of dope solution concentration and PVDF molecular weights on membrane morphologies and the corresponding microspheres characteristics were investigated. Results showed that concentration of 20 wt% produced microspheres at desirable size of 24.14 µm and the optimal span of 0.53. Microspheres with narrow distribution showed the highest drug loading efficiency of baicalin at 8.42 %. The baicalin loaded PCL microspheres presented gradual release of drug release over 33-day of in vitro testing and significantly improved cell growth rate of 111.67 % as compared to the ones prepared by homogenization approach. The wound healing ability was enhanced after the treatment of baicalin-loaded PCL microspheres as compared to empty loaded PCL microspheres.
Whole-Brain Radiotherapy Simultaneous Integrated Boost Intensity-Modulated Radiotherapy Combined With Anlotinib in the Treatment of Brain Metastases
Authors: Tao Wei , Jiang Chunyu , Xie Jiaqi , Liu Wei , Wang Shuan , Zhang Jianyu , Qiao Xue , Yu Jingyi , Jia Ting , Cao Yuandong 
Published: February 2025

Introduction Whole-brain radiotherapy simultaneous integrated boost intensity-modulated radiotherapy (WBRT + SIB-IMRT) is a potential treatment approach for brain metastasis (BM) that may result in improved overall survival (OS). However, the safety and efficacy of WBRT + SIB-IMRT combined with anlotinib for BM treatment remain uncertain. Methods We retrospectively compared the safety and efficacy of anlotinib + WBRT + SIB-IMRT with those of WBRT + SIB-IMRT in patients with BM from 2019 to 2022. The adverse reaction type and grade, intracranial objective response rate (iORR), intracranial disease control rate (iDCR), OS, and intracranial progression-free survival (iPFS) of anlotinib + WBRT + SIB-IMRT were compared with those of WBRT + SIB-IMRT alone. Results In total, 63 patients received either anlotinib + WBRT + SIB-IMRT or WBRT + SIB-IMRT alone (n = 31 and 32, respectively). No significant clinical differences were found between the two groups. The iORR and iDCR were higher in the anlotinib + WBRT + SIB-IMRT group than in the WBRT + SIB-IMRT group. The median iPFS and median OS of the 31 patients who received anlotinib + WBRT + SIB-IMRT were 14.5 and 18.9 months, respectively, whereas the median iPFS and median OS for the 32 patients who received WBRT + SIB-IMRT alone were 11.4 and 14.9 months, respectively. Thus, anlotinib combined with WBRT + SIB-IMRT increased the duration of iPFS, but not OS. iPFS was influenced by the Karnofsky Performance Status (KPS) score, age, extracranial distant metastasis, and addition of anlotinib to treatment, whereas OS correlated with age, extracranial distant metastasis, and KPS score. No treatment-related adverse events of grade 3 or higher occurred in either group. Conclusions Anlotinib combined with WBRT + SIB-IMRT is effective for BM and is well tolerated by patients.
Incidence and Outcomes of Tree Stand Injuries in Rural Pennsylvania
Authors: Lachance Andrew , Oravic Michael , Steika Roman , Crymes Colt , Aynaszyan Stephan , Gagliardi Alexia , Choi Joseph 
Published: February 2025

Introduction In the United States, more than 11.5 million people participate in hunting. Deer hunters commonly use tree stands as tall as 8 m. Falls from tree stands can cause injury and even death. Previous studies have investigated the types of injuries sustained from tree stand falls, but few have investigated patient outcomes. This study investigated patient outcomes related to tree stand falls and analyzed injury types resulting from tree stand falls, and this paper discusses factors that may lead to tree stand falls. Methods This study used a retrospective chart review of patients at the same institution between January 1, 2012, and August 31, 2022. Patient information, injury type, fall height, and interventions were collected. Results A total of 38 patients were included in the study, 36 males (94.70%) and 2 females (5.30%). The average fall height from a tree stand was 4.22±1.62 m (13.86±5.30 ft). Of the 38 patients, 19 had sustained orthopedic injuries to their upper extremity, lower extremity, spine/pelvis, or multiple areas; the average fall height of this subgroup was 4.51±1.76 m (14.79±5.76 ft). Nonoperative management was the highest used intervention because 12 patients did not require surgery. Orthopedic surgery was used to treat 6 patients, and 1 patient had nonorthopedic surgery. Conclusions Although tree stand falls are rare, the injuries they cause can be fatal. Injury severity and outcome are determined by a multitude of factors. This study highlights the significance of these injuries and the importance of practicing safe guidelines while hunting.
I Wish I Had Known That! Impactful Guidance and Perspectives for a Fulfilling Career in Toxicology
Authors: Graham Jessica C. , Bercu Joel , Fortin Marie C. , Kiorpes Andy , Sethi Sunjay , Roy Robert 
Published: February 2025

Have you ever reflected on your career or other experiences and thought, if I knew 10 or 20 years ago, what I know now, it would have enabled me to do this or that better—or I would have had a different attitude or perhaps even taken a different path? This article presents the proceedings from the symposium entitled “I Wish I Had Known That! Impactful Guidance and Perspectives for a Fulfilling Career in Toxicology” held at the 2023 annual meeting of the American College of Toxicology. In this session, toxicology professionals reflected on the highlights of their careers, the most impactful advice/mentoring they received or wish they had received, and the characteristics that have been key components of their success. This session consisted of didactic talks from a diverse panel representing various career stages and backgrounds, followed by a panel discussion and the opportunity for the audience to ask questions. Using a structured approach, speakers actively engaged the audience, providing insights gained through their professional journeys. This article offers experiential-based insights to help guide individuals in achieving successful and fulfilling careers in toxicology, considering both professional aspirations and the integration of personal values with life goals.
Long-term impact of physical activity and sports participation on implant integrity in resurfacing hip arthroplasty versus total hip arthroplasty: a systematic review
Authors: Levett Jordan J , Alnasser Abdulrhman , Teoli Anthony , Martel Simon , Robbins Shawn , Huk Olga L , Zukor David J , Antoniou John 
Published: February 2025

Objectives: Total hip arthroplasty (THA) and resurfacing hip arthroplasty (RHA) offer promising therapeutic solutions to physically active patients with hip osteoarthritis (OA). The impact of physical activity on long-term implant integrity in this population remains unknown. This systematic review compares the impact of physical activity and sports participation on implant integrity in THA versus RHA. Methods: A comprehensive search of Medline, Embase (both via Ovid), Scopus, and CINAHL was conducted from inception to May 2023 following the Cochrane Handbook for Systematic Reviews of Interventions. Data were reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The quality of included studies was assessed using the Newcastle-Ottawa Scale. Implant integrity was measured either radiographically, via serum metal ion levels or revision rates. Results: A total of 16 studies with 4676 patients (THA: 3146; RHA: 1530) met the inclusion criteria. The median age at surgery was 60 years (range 49 to 86) in THA and 54 (range 49–61) years in RHA. At a median follow-up of 7.1 (range 4.8–13.1) years in THA and 10 (range 2.8–11.7) years in RHA, 3 studies out of 12, including 65.7% of the patients who underwent THA, and 2 studies out of 5, including 30.1% of the patients who underwent RHA, demonstrated that increased physical activity was associated with poor implant survivorship. Conclusions: Patients undergoing THA or RHA should be counselled to participate in moderate physical activity and may benefit from avoiding sports that exert an excessive load on their implants. On average, the quality of the studies was moderate. The outcome measures used to quantify physical activity and implant integrity are heterogenous.
Encapsulated papillary carcinoma of breast: Comparative study of multimodal ultrasound manifestations and pathological features
Authors: Wu Zehong , Li Huajuan , Chen Zihao , Zhou Honglian , Liang Xin , Huang Xing , Wang Jiexin , Chen Ting , Xu Xiaohong , Yang Yuping 
Published: February 2025

Objective To investigate the conventional ultrasound (US), contrast-enhanced ultrasound (CEUS) manifestations and the corresponding histopathological characteristics of patients diagnosed with breast encapsulated papillary carcinoma (EPC) and to explore the value of CEUS in diagnosis of EPC. Methods The clinical, pathological, US, and CEUS features of 16 patients (17 lesions) with EPC confirmed by postoperative histopathology were retrospectively analyzed. Results EPC was prevalent in the postmenopausal women. The majority of conventional US images of EPC showed complex cystic and solid masses with circumscribed margins (70.6%), enhanced posterior echo (94.1%), no sonographic calcification (88.2%), rich blood flow in the solid components within lesions (70.6%) on Color Doppler flow imaging, and high resistance index of blood flow (94.1%). Moreover, CEUS showed mainly centripetal hyperenhancement of the solid components within the lesions with irregular outline, and the enhancement area of the whole masses was essentially the same as the B-mode US area. Conclusions EPC typically presents as a complex cystic and solid mass. CEUS is helpful to clarify the extent of the solid component and facilitate preoperative core-needle biopsy. A comprehensive evaluation by CEUS is valuable for diagnosing EPC and combining it with clinical features are helpful to further improve the diagnosis of this rare kind of breast cancer.
The modulation of endothelial glycocalyx by sulodexide on the porcine model of enzymatic endothelial glycocalyx damage – a pilot study
Authors: Astapenko David , Gorskaja Diana , Zrzavecky Marek , Kawashima Hanako , Ssali Edward , Navratil Pavel , Hana Ludek , Motesicky Jan , Radochova Vera , Hyspler Radomir , Ticha Alena , Lehmann Christian , Malbrain Manu LNG , Zadak Zdenek , Cerny Vladimir 
Published: February 2025

Background: Sulodexide is a glycosaminoglycan-based drug prescribed to patients with angiopathy. We performed a pilot study to investigate whether sulodexide positively modulates the endothelial glycocalyx (EG) layer and the microcirculation in a porcine model of EG enzymatic damage. The EG is a sugar-based endothelial lining that is involved in the physiology of the capillary wall and the pathogenesis of many diseases. Methods: EG damage was induced in eight piglets by hyaluronidase III and heparanase I given intravenously. Four animals received sulodexide 600 IU intravenously before the enzymes and four animals after the enzymes were administered. Four animals constituted a control group. Sublingual microcirculation by side-stream dark field imaging and plasmatic concentration of syndecan-1 by ELISA were measured at baseline, 20 min after intervention, and at the 40th, and 60th minute onwards. The statistics were performed with a one-way ANOVA test with Turkey's correction for multiple comparisons testing. Timepoint comparison was performed by Student t-test or Mann-Whitney test. Results: At baseline, there were no statistically significant differences between the animal groups. After the intervention, the levels of syndecan-1 were significantly lower in the control group. While there were no differences between the two intervention groups. The sublingual microcirculation analysis showed that the DeBacker score was significantly higher in the control group. At 60 min, there was also a statistically significant difference in DeBacker score between the groups (8.1 ± 1.6 mm−1 in the group with enzymes given first and 11 ± 0.92 mm−1 in the group with sulodexide given first, p = 0.03). The analysis of the proportion of perused vessels did not show any statistically significant differences. Conclusion: The results of the study demonstrated a working model of EG damage but no specific action of sulodexide on EG modulation. In the sublingual microcirculation analysis, the sulodexide reduced the fall in absolute tissue perfusion in 60 min.
Prevention of ischemia-reperfusion injury on the porcine model of supra-renal aortic clamp by sulodexide
Authors: Hana Ludek , Tlapakova Katerina , Cizkova Dana , Ticha Alena , Lehmann Christian , Cerny Vladimir , Hahn Robert G , Koci Jaromir , Astapenko David 
Published: February 2025

Background The ischemia-reperfusion injury (IRI) is unavoidable in vascular surgery. Damage to the microcirculation and endothelial glycocalyx might set up a shock with loss of circulatory coherence and organ failure. Sulodexide may help to protect endothelial glycocalyx and alleviate the ischemia-reperfusion injury. Methods Twenty female piglets underwent surgery with a 30-min-long suprarenal aortic clamp, followed by two hours of reperfusion. Ten piglets received sulodexide before the clamp, and 10 received normal saline. Blood and urine samples were taken at baseline and in 20-min intervals until the 120th minute to analyze the serum syndecan-1, E-selectin, and thrombomodulin. Albumin and glycosaminoglycans were examined in the urine. The kidney biopsies before and after the protocol were examined by light microscopy with hematoxylin-eosin staining. The sublingual microcirculation was recorded by side-stream dark field imaging at the time as blood and urine. Results Based on the 2-way ANOVA testing, there was no statistically significant difference in the parameters of sublingual microcirculation. Serum markers of endothelial cell activation and damage (E-selectin and thrombomodulin) did not show any statistically significant difference either. Syndecan-1, a marker of glycocalyx damage, showed statistically significantly higher values based on the 2-way ANOVA testing (p < 0.0001) with the highest difference in the 80th minute: 7.8 (3.9–44) ng/mL in the control group and 1.8 (0.67–2.8) ng/mL in the sulodexide group. In the urine, the albuminuria was higher in the control group, although not statistically significant. Glycosaminoglycans were statistically significantly higher in the sulodexide group based on the mixed-effect analysis due to the intervention itself. Histological analysis of the renal biopsies showed necrosis in both groups after reperfusion. Conclusion Administering sulodexide significantly reduced the level of endothelial markers of IRI. The study results support further research into using preemptive administration of sulodexide to modulate IRI in clinical medicine.