bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evans syndrome: Disease awareness and clinical management in a nation‐wide ITP‐NET survey
Authors: Fattizzo Bruno , Carrai Valentina , Crugnola Monica , Baldacci Erminia , Bellini Marta , Bosi Costanza , Buzzatti Elisa , Caramazza Domenica , Carli Giuseppe , Carpenedo Monica , Clissa Cristina , Danesin Cristina , De Paolis Maria Rosaria , Giannotta Juri Alessandro , Innao Vanessa , Marchetti Monia , Markovic Uros , Morotti Alessandro , Napolitano Mariasanta , Patriarca Andrea , Pettine Loredana , Poloni Antonella , Rivolti Elena , Rossi Elena , Santeremo Teresa Maria , Santoro Cristina , Zannier Maria Elena , Zaja Francesco , Cantoni Silvia , Palandri Francesca , De Stefano Valerio 
Published: June 2024

AbstractEvans syndrome (ES) is rare and mostly treated on a “case‐by‐case” basis and no guidelines are available. With the aim of assessing disease awareness and current management of adult ES, a structured survey was administered to 64 clinicians from 50 Italian participating centers. Clinicians had to be involved in the management of autoimmune cytopenias and were enrolled into the ITP‐NET initiative. The survey included domains on epidemiology, diagnosis, and therapy of ES and was designed to capture current practice and suggested work‐up and management. Thirty clinicians who had followed a median of 5 patients (1–45)/15 years responded. The combination of AIHA plus ITP was more common than the ITP/AIHA with neutropenia (p < .001) and 25% of patients had an associated condition, including lymphoproliferative syndromes, autoimmune diseases, or primary immunodeficiencies. The agreement of clinicians for each diagnostic test is depicted (i.e., 100% for blood count and DAT; only 40% for anti‐platelets and anti‐neutrophils; 77% for bone marrow evaluation). Most clinicians reported that ES requires a specific approach compared to isolated autoimmune cytopenias, due to either a more complex pathogenesis and a higher risk of relapse and thrombotic and infectious complications. The heterogeneity of treatment choices among different physicians suggests the need for broader harmonization.
HCV‐HIV co‐infection in people who inject drugs: Barriers to treatment and cure of HCV infection in the era of DAAs, a prospective study in Athens, Greece
Authors: Basoulis Dimitris , Mastrogianni Elpida , Eliadi Irene , Papadopoulou Martha , Psichogiou Mina 
Published: June 2024

AbstractObjectivesHIV/hepatitis C virus (HCV) co‐infection among people who inject drugs (PWID) remains a global health problem. The goal of our study was to evaluate, in a real‐world setting, success rates of sustained virological response (SVR) using direct‐acting antivirals (DAAs) to treat a population of PWID living with HCV/HIV.MethodsThis was a prospective single‐center observational study. We collected demographic, socioeconomic, and clinical data pertaining to HIV and HCV infection in PWID with several barriers to care. We identified risk factors for SVR failure.ResultsAmong 130 individuals retained to HIV care, we planned HCV treatment in 119/130 (91.5%); 106/119 (89.1%) started treatment with DAAs and 100/106 (94.3%) completed treatment. People not starting treatment were more often in active opioid drug use (odds ratio [OR] 0.25; 95% confidence interval [CI] 0.07–0.97, p = 0.045) and benzodiazepine abuse (OR 0.25; 95% CI 0.07–0.95, p = 0.042). Only 86/100 (86%) were tested for SVR at 12 weeks (SVR12) and 72/86 (83.7%) achieved SVR. PWID in opioid substitution programmes tended to return for SVR12 testing more often (54.7% vs. 30%, p = 0.081). Individuals in active opioid drug use (OR 0.226; 95% CI 0.064–0.793, p = 0.02) or with poor adherence (OR 0.187; 95% CI 0.043–0.814, p = 0.025) were less likely to achieve SVR. At the end of our study period, 113/119 (95%) treatment‐eligible patients remained alive. HCV infection was cured in 68/113 (61.1%) people.ConclusionsOur findings underscore the importance of prioritizing combatting substance use to achieve HCV elimination goals. A systematic approach with effort to overcome barriers to receiving and completing treatment and encourage to enrol in opioid substitution programmes if not possible to completely abstain from use, can help increase chances of HCV cure.
Adverse Effects Related to Paediatric Influenza Vaccination and Its Influence on Vaccination Acceptability. The FLUTETRA Study: A Survey Conducted in the Region of Murcia, Spain
Authors: Zornoza Moreno Matilde , Pérez Martín Jaime Jesús , Gómez Moreno María Cruz , Valcárcel Gómez María del Carmen , Pérez Martínez Marta , Tornel Miñarro Francisca Isabel 
Published: June 2024

ABSTRACTBackgroundDuring the 2022–23 season, three autonomous communities recommended influenza vaccination for all children between 6 and 59 months. The objective is to evaluate the adverse effects associated with the administered influenza vaccines in the Region of Murcia, as well as their influence on the recommendation of the same to acquaintances or repetition in future seasons.Material and MethodsCross‐sectional descriptive study with an online questionnaire sent to the parents of vaccinated minors of 6–23 months of age receiving inactivated intramuscular vaccine (IIV) or 24–59 months of age receiving live‐attenuated intranasal vaccine (LAIV).ResultsAmong 4971 surveys received, the most common adverse effect for LAIV and IIV was runny nose (40.90%) and local pain (31.94%), respectively. Sixty percent of adverse effects lasted ≤ 1 day, and around 10% lasted ≥ 3 days. The interference of adverse effects with the minor's daily life was very infrequent (3.32%), as was the need for visiting the medical office (2.68%). Overall, 96.44% of parents would recommend influenza vaccination to friends and relatives after the experience. Only 3.56% would not recommend it, while 1.68% would not vaccinate their child against influenza again. The most frequently cited reason being adverse effects.ConclusionsOur study shows the safety of influenza vaccines. Despite the low impact of adverse effects, they influence some parents in their intention to continue vaccinating or recommending it to acquaintances, which remarks the need to reinforce the information given to parents so that this fact does not influence decision‐making.
Reducing low‐value imaging—A qualitative evaluation of a pilot intervention in Norway
Authors: Andersen Eivind Richter , Hofmann Bjørn Morten , Brandsæter Ingrid Øfsti , Kjelle Elin 
Published: June 2024

AbstractRationalLow‐value radiological imaging threatens patient safety and efficient use of limited health resources. It is important to evaluate measures for reducing low‐value utilisation, to learn and to improve. Accordingly, the objective of this study was to qualitatively evaluate a pilot intervention for reducing low‐value imaging in Norway.MethodsSemi‐structured interviews were conducted aimed at describing stakeholders' experience with a multicomponent pilot intervention consisting of a standardised procedure for referral assessment, a standardised return letter, and information about the value and possible risks of magnetic resonance imaging‐examinations to the public. Data were analysed in line with qualitative content analysis with a deductive approach.ResultsSeven healthcare providers were interviewed, including two radiologists, two radiographers, one manual therapist, one practice consultant and one general practitioner. Data analysis yielded four categories: (1) information and reception, (2) referral‐ and assessment processes, (3) suggestions for improvement and facilitation and (4) outcomes of the pilot intervention.ConclusionsThe pilot intervention was deemed acceptable, feasible, engaging and relevant. Specific training in the use of the new procedure was suggested to improve the intervention. The simple design, as well as the positive acceptance demonstrated and the few resources needed, make the pilot intervention and methodology highly relevant for other settings or when aiming to reduce the number of other low‐value radiology examinations.
Best practices for collecting and preserving marine mammal biological samples in the ‘omics era
Authors: Van Cise Amy M. , Switzer Alexandra D. , Apprill Amy , Champagne Cory D. , Chittaro Paul M. , Dudek Natasha K. , Gavery Mackenzie R. , Hancock‐Hanser Brittany L. , Harmon Alaina C. , Jaffe Alexander L. , Kellar Nicholas M. , Miller Carolyn A. , Morin Phillip A. , Nelms Sarah E. , Robertson Kelly M. , Schultz Irvin R. , Timmins‐Schiffman Emma , Unal Ebru , Parsons Kim M. 
Published: June 2024

AbstractThe recent rise of ‘omics and other molecular research technologies alongside improved techniques for tissue preservation have broadened the scope of marine mammal research. Collecting biological samples from wild marine mammals is both logistically challenging and expensive. To enhance the power of marine mammal research, great effort has been made in both the field and the laboratory to ensure the scientific integrity of samples from collection through processing, supporting the long‐term use of precious samples across a broad range of studies. However, identifying the best methods of sample preservation can be challenging, especially as this technological toolkit continues to evolve and expand. Standardizing best practices could maximize the scientific value of biological samples, foster multi‐institutional collaborative efforts across fields, and improve the quality of individual studies by removing potential sources of error from the collection, handling, and preservation processes. With these aims in mind, we summarize relevant literature, share current expert knowledge, and suggest best practices for sample collection and preservation. This manuscript is intended as a reference resource for scientists interested in exploring collaborative studies and preserving samples in a suitable manner for a broad spectrum of analyses, emphasizing support for ‘omics technologies.
Establishing a community‐academic nursing partnership to lead a healthcare response during a human trafficking extraction operation
Authors: Barnett Katherine , Saye Jamie , Beidler Susan M. 
Published: June 2024

AbstractA community‐academic nursing partnership formed to care for the urgent healthcare needs of individuals extracted from human trafficking during a multidisciplinary team operation. During past human trafficking extraction operations, law enforcement and the state sexual assault nurse examiner coordinator recognized the need to meet the patients' immediate physical and emotional needs while providing essential comfort to the newly extracted individuals. To meet the immediate holistic healthcare needs during the recovery operation, the nursing faculty partnered with a local nonprofit community clinic to provide onsite trauma‐informed, patient‐centered healthcare and comfort items. The healthcare team consisted of advanced practice nurses, mental health nurses who triaged the patient's immediate psychological needs, sexual assault nurses who collected forensic specimens, and nurses with expertise in substance use disorder who evaluated the patient's treatment needs. The patient's physical comfort was met by providing hygiene kits, blankets, socks, food, and drinks. Trauma‐informed language was utilized to help the patient feel safe and to convey respect for the patient's autonomy in making decisions during the extraction process. The innovative community‐academic nursing partnership laid the groundwork for providing healthcare to future human trafficking extraction operations with plans to incorporate nursing students and graduate nursing students to increase the number of patients served while providing a rich learning experience to the students.
Analytical and numerical solutions for the boundary layer flow and heat transfer over a moving wedge in Casson fluid
Authors: Joshi Shrivatsa R. , Kirsur Shreenivas R. , Nargund Achala L. 
Published: June 2024

AbstractThis paper presents exact, analytical, and numerical solutions to the two‐dimensional Casson fluid boundary layer flow over a moving wedge with varying wall temperature. The boundary layer flow of the Casson fluid with varying wall temperature is governed by a system of partial differential equations called Prandtl boundary layer equations modified by Casson fluid. By applying similarity transformations the governing system of partial differential equations is reduced to a system of nonlinear ordinary differential equations called as the Falkner–Skan equation modified by Casson fluid flow with heat transfer (C‐FSEHT). In the beginning, an exact solution of the C‐FSEHT is obtained for the particular values of physical parameters (i.e., , , , see nomenclature) in terms of two standard functions, namely error function and exponential function. Thus, obtained exact solution is then modified to obtain the analytical solution of C‐FSEHT for general values of physical parameters, in terms of power series. The analysis of the asymptotic behavior of the problem, when the wedge velocity is very large (), is performed using the Dirichlet series. A comparative analysis is performed using the Chebyshev collocation technique (CCT) to validate the obtained results in all the scenarios. The effect of governing parameters, which are the Casson parameter , Hartree pressure gradient parameter , moving wedge parameter , Prandtl number , and wedge temperature parameter on the skin friction coefficient, temperature coefficient, velocity profiles, and temperature profiles is discussed in detail. Multiple solutions are found analytically for fixed values of governing parameters. The fact that an increase in the value of the Casson parameter () reduces the thickness of both velocity and temperature boundary layers, is also validated during the study.
Temporal trends and distributional changes in cardiorespiratory fitness among Chinese children and adolescents from 1985 to 2019
Authors: Li Chengyue , Zhang Juanxin , Maisiwute Maierdan , Zhou Zhidong , Zang Liuhong 
Published: June 2024

AbstractObjectivesThe aim of this study was to analyze the temporal trends in cardiorespiratory fitness (CRF) and body mass index (BMI) among children and adolescents from 1985 to 2019.MethodsA total of 1 840 212 children and adolescents aged 7–18 years (921 223 boys) were tested for CRF from 1985 to 2019. CRF was tested by 50‐m × 8 shuttle run for boys and girls aged 7–12 years, 1000‐m run for boys aged 13–18 years, and 800‐m run for girls aged 13–18 years. Trends in BMI from 2000 to 2019 were also investigated.ResultsCardiorespiratory fitness decreased during the entire 34 years among children and adolescents in all sex and age categories, and the most rapid decline occurred from 1995 to 2005. Some positive trends in CRF were observed among adolescents aged 13–15 years from 2005 to 2019 and among girls aged 16–18 years from 2014 to 2019. The variation in the CRF distribution was not uniform, with Z‐scores for participants with high CRF levels changing little or increasing (CRF stabilized or improved) and Z‐scores for participants with low CRF levels continuing to decrease (CRF decreased). BMI increased over time for boys and girls in all age categories, with an acceleration of the increase for adolescents in recent years.ConclusionsThis study revealed that the overall CRF levels of Chinese children and adolescents decreased over three decades but stabilized or improved in recent years. BMI continued to increase. Our findings are important for the focus on future domestic physical fitness and public health.
Computed tomography‐derived structural analysis for the likelihood of pathologic fracture in canine antebrachial osteosarcoma
Authors: Steffey Michele A. , Garcia Tanya C. , Gorney Angela , Stover Susan M. , Zwingenberger Allison L. 
Published: June 2024

AbstractDetermining the risk of pathologic fracture in dogs with a primary bone tumor would aid in case selection for in‐situ treatment options. Prior research found strong relationships between in vitro strength of canine antebrachii with primary bone tumors and CT‐derived metrics. This study assesses the prognosis for pathologic fracture in dogs with distal radial bone tumors using CT‐derived structural analysis metrics. CT images of the antebrachium in dogs with aggressive osseous lesions of the radius were used to calculate structural rigidity and failure forces, including axial rigidity (AR), craniocaudal bending rigidity (BR), torsional rigidity (TR), and failure forces for a slightly‐curved/asymmetric beam (Fs) or a curved beam (Fc). Metrics were compared with the clinical outcome of radial fracture. Eight of 19 dogs with CT‐derived metrics developed a radial fracture. The prognostic potential of the metrics to discriminate fractured and nonfractured bones was analyzed using receiver operating characteristic curves (area under the curve), stepwise logistic regression, and classification regression (CART) analyses. Fc was the most sensitive and specific metric for prognosing fracture occurrence (AUC = 0.864). When dog body weight (BW) was included, all five metrics had AUC > 0.705. Fc was the best predictor of fracture using stepwise logistic regression and CART analysis, followed by BR. An indication of fracture probability can be determined by normalizing Fc or BR with dog BW or by using the logistic regression equation of either metric with dog BW. Results warrant further analysis of a larger cohort to evaluate fracture likelihood in dogs with antebrachial bone neoplasia.
Defining the value of medical microbiology consultation
Authors: Rodino Kyle G. , Luethy Paul M. , Abbott April N. , Bender Jeffrey M. , Eberly Allison R. , Gitman Melissa , Leber Amy , Dien Bard Jennifer ,   on behalf of the Personnel Standards and Workforce Subcommittee, American Society for Microbiology
Published: June 2024

ABSTRACT

Medical microbiologists, defined as doctoral-level laboratory directors with subspecialty training in medical microbiology, lead the clinical laboratory operations through activities such as clinical consultations, oversight of diagnostic testing menu, institutional leadership, education, and scholastic activities. However, unlike their clinical colleagues, medical microbiologists are largely unable to bill for clinical consultations performed within the hospital and, therefore, unable to generate relative value units or a similar quantifiable metric. As hospital budgets tighten and justification of staffing becomes a necessity, this may present a challenge to the medical microbiologist attempting to prove their value to the organization. To aid in providing tangible data, the Personnel Standards and Workforce subcommittee of the American Society for Microbiology conducted a multi-center study across seven medical centers to document clinical consultations and their impact. Consults were generated equally from internal (laboratory-based) and external (hospital-based) parties, with the majority directly impacting patient management. Near universal acceptance of the medical microbiologist’s recommendation highlights the worth derived from their expertise. External consults required more time commitment from the medical microbiologist than internal consults, although both presented ample opportunity for secondary value, including impact through stewardship, education, clinical guidance, and cost reduction. This study is a description of the content and impact of consultations that underscore the importance of the medical microbiologist as a key member of the healthcare team.

IMPORTANCE
Medical microbiologists are invaluable to the clinical microbiology laboratory and the healthcare system as a whole. However, as medical microbiologists do not regularly generate relative value units, capturing and quantifying the value provided is challenging. As hospital budgets tighten, justification of staffing becomes a necessity. To aid in providing tangible data, the Personnel Standards and Workforce subcommittee of the American Society for Microbiology conducted a multi-center study across seven medical centers to document clinical consultations and their impact. To our knowledge, this is the first study to provide detailed evaluation of the consultative value provided by medical microbiologists.
Granitic mush compaction by impingement of a large felsic enclave: Evidence from the Aztec Wash pluton (Nevada, USA)
Authors: Teeter Elizabeth C. , Gualda Guilherme A.R. , Miller Calvin F. 
Published: June 2024

Abstract
Compaction and melt extraction are key processes in the generation of melt-dominated magma bodies. We analyze magmatic fabrics in the Aztec Wash pluton (15.7 Ma; Nevada, USA) to understand magma dynamics during emplacement of a large (2 m diameter) felsic enclave (LFE) in a silicic magma body. We hypothesize that the LFE moved through crystal-poor magma, settling into crystal-rich magma. We analyze four granite samples collected near the enclave: two 0.25 m below the enclave (E-5 and E-2); one 0.5 m below (E-6); and one 2.5 m to the side (E-3, far field). We use the scanning electron microscope (SEM) to gather data using backscattered electron (BSE) microscopy, energy dispersive spectroscopy (EDS), and electron backscatter diffraction (EBSD) imaging. BSE maps show large (up to 10 mm) euhedral alkali feldspar grains in E-5 and E-2, while E-6 and E-3 have large (up to 6 mm) alkali feldspar with distinct irregular and wavy rims. Dark BSE alkali feldspar rims correlate with Ba depletion in EDS maps. Broken feldspars in E-5 and E-2 have mismatched zones in BSE and orientation differences in EBSD. Grain orientation spread (GOS) maps show that alkali feldspar has the highest degree of intragrain deformation, followed by plagioclase, then quartz. Histograms of the angle between the vertical plane and the pole to the (010) plane demonstrate clustering in E-5, suggesting an enhanced fabric. Differences in rim texture suggest melt extraction beneath the enclave and melt retained in the far field. EBSD data reveal an enhanced foliation beneath the LFE. We conclude that mush under the LFE was deformed during emplacement of the LFE, expelling melt and reorienting grains.
Barriers to initiating and implementing palliative and end-of-life care for children with life-limiting conditions: a mixed-methods study in a UK children’s hospital
Authors: Umezurike Indira , Dittborn Mariana , Whitelaw James , Bedford Helen , Brierley Joe 
Published: June 2024

BackgroundTo ensure that children with life-limiting conditions (LLC) and their families have access to a palliative care pathway from diagnosis to death and bereavement, a better understanding of the challenges experienced by paediatric healthcare professionals caring for children with LLC is needed.AimTo explore the barriers paediatricians face in initiating and implementing palliative and end-of-life care for children with LLC.MethodsDue to the challenges of COVID-19, the study was performed as a service evaluation using semi-structured interviews and an online questionnaire with consultant paediatricians in general paediatrics, community paediatrics and multiple subspecialties at a UK children’s hospital between December 2020 and August 2021. Twelve interviews and 18 online questionnaires were completed. Interviews were analysed using reflexive thematic analysis, and descriptive statistics were used for questionnaire responses.ResultsRecurring themes from both data sets were further analysed and five themes were developed: (1) Problems with the leadership of palliative and end-of-life care; (2) Problems with preparing advanced care plans; (3) Lack of training in paediatric palliative care and advanced communication; (4) Problems communicating with families; and (5) Lack of recognition of children with LLC and high-profile cases.ConclusionsWe found that the barriers to effective palliative and end-of-life planning are multifaceted and pervasive, so healthcare professionals must establish clearer pathways to overcome them. Approaches suggested included (1) discussing palliative care for children with LLC at professional encounters, for example, departmental meetings, peer-review meetings and morbidity and mortality meetings and (2) advanced communication training in palliative and end-of-life care.