bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of 30-Day Mortality for ICU Patients with Sepsis-3
Authors: Yu Z , Ashrafi N , Li H , Alaei K , Pishgar M 
Published: May 2024

ABSTRACTBackgroundThere is a growing demand for advanced methods to improve the understanding and prediction of illnesses. This study focuses on Sepsis, a critical response to infection, aiming to enhance early detection and mortality prediction for Sepsis-3 patients to improve hospital resource allocation.MethodsIn this study, we developed a Machine Learning (ML) framework to predict the 30-day mortality rate of ICU patients with Sepsis-3 using the MIMIC-III database. Advanced big data extraction tools like Snowflake were used to identify eligible patients. Decision tree models and Entropy Analyses helped refine feature selection, resulting in 30 relevant features curated with clinical experts. We employed the Light Gradient Boosting Machine (LightGBM) model for its efficiency and predictive power.ResultsThe study comprised a cohort of 9118 Sepsis-3 patients. Our preprocessing techniques significantly improved both the AUC and accuracy metrics. The LightGBM model achieved an impressive AUC of 0.983 (95% CI: [0.980-0.990]), an accuracy of 0.966, and an F1-score of 0.910. Notably, LightGBM showed a substantial 6% improvement over our best baseline model and a 14% enhancement over the best existing literature. These advancements are attributed to (I) the inclusion of the novel and pivotal feature Hospital Length of Stay (HOSP_LOS), absent in previous studies, and (II) LightGBM’s gradient boosting architecture, enabling robust predictions with high-dimensional data while maintaining computational efficiency, as demonstrated by its learning curve.ConclusionsOur preprocessing methodology reduced the number of relevant features and identified a crucial feature overlooked in previous studies. The proposed model demonstrated high predictive power and generalization capability, highlighting the potential of ML in ICU settings. This model can streamline ICU resource allocation and provide tailored interventions for Sepsis-3 patients.
Chlamydia-driven ISG15 expression dampens the immune response of epithelial cells independently of ISGylation
Authors: Wu Yongzheng , Liu Chang , Tang Chongfa , Niragire Béatrice , Levy-Zauberman Yaël , Adapen Cindy , Vernay Thomas , Hugueny Juliette , Baud Véronique , Subtil Agathe 
Published: May 2024

ABSTRACTExcessive inflammation uponC. trachomatisinfection can cause severe damages in the female genital tract. This obligate intracellular bacterium develops mainly in epithelial cells, whose innate response contributes to the overall inflammatory response to infection. The ubiquitin-like protein interferon-stimulated gene 15 (ISG15) stimulates interferon γ (IFNγ) production and is required for bacterial clearance in several infectious contexts. Here, we describe and investigate the consequences of the increase in ISG15 expression by epithelial cells infected withC. trachomatis. Infection of HeLa cells and primary ecto-cervical epithelial cells resulted in a transcriptional up-regulation ofISG15expression. This did not involve the canonical IFN-I signaling pathway and depended instead on the activation of the STING/TBK1/IRF3 pathway. Absence or reduction of ISG15 synthesis led to increased production of several cytokines and chemokines including interleukin (IL) 6 and IL8, implicating that ISG15 normally dampens the immune response induced byC. trachomatisinfection in epithelial cells. ISG15 exerted its control from an intracellular location, but without involving ISGylation. Finally, higher levels of inflammation and delayed bacterial clearance were observed in the genital tracts of ISG15-KO mice infected byC. trachomatiscompared to wild type animals, however IFNγ production was unchanged. Altogether, our data show that ISG15 expression acts as a brake on the immune response toC. trachomatisinfection in epithelial cells and limits bacterial burden and inflammation in mice.
The effects of daylight saving time clock changes on accelerometer-measured sleep duration in the UK Biobank
Authors: de Lange Melanie A , Richmond Rebecca C , Birnie Kate , Shapland Chin Yang , Tilling Kate , Davies Neil M 
Published: May 2024

AbstractWe explored the effects of daylight saving time (DST) clock changes on sleep duration in a large accelerometer dataset. Our sample included UK Biobank participants (n= 11,780; aged 43-78) with accelerometer data for one or more days during the two weeks surrounding the Spring and Autumn DST transitions from October 2013 and November 2015. Between-individual t-tests compared sleep duration on the Sunday (midnight to midnight) of the clock changes to the Sunday before and the Sunday after. We also compared sleep duration on all other days (Monday-Saturday) before and after the clock changes. In Spring, mean sleep duration was 65 minutes lower on the Sunday of the clock changes than the Sunday before (95%CI -72 to -58 minutes) and 61 minutes lower than the Sunday after (95%CI -69 to -53). In Autumn, the mean sleep duration on the Sunday of the clock changes was 33 minutes higher than the Sunday before (95% CI 27 to 39 minutes) and 38 minutes higher than the Sunday after (95% CI 32 to 43 minutes). There was some evidence of catch-up sleep after both transitions, with sleep duration a little higher on the Monday - Friday than before, although this was less pronounced in Autumn. Future research should use large datasets with longer periods of accelerometer wear to capture sleep duration before and after the transition in the same individuals, and examine other aspects of sleep such as circadian misalignment, sleep fragmentation or daytime napping.
Protecting against Respiratory Syncytial Virus: An online questionnaire study exploring UK parents’ acceptability of vaccination in pregnancy or monoclonal antibody administration for infants
Authors: Paulson Simone , Munro Alasdair PS , Cathie Katrina , Bedford Helen , Jones Christine E 
Published: May 2024

AbstractIntroductionMaternal vaccination and infant monoclonal antibodies are promising avenues to protect young infants from respiratory syncytial virus (RSV) infection. Successful inclusion into the UK immunisation schedule depends on parental acceptability, among other factors.MethodsAn online cross-sectional survey from August to September 2023 exploring the likelihood of accepting, and preference for, either method of RSV prophylaxis, and reasons given for these. A questionnaire was distributed via social media networks to UK participants with a child under the age of 2 years and/or pregnant.ResultsA total of 1620 participants completed the survey. Participants’ median age was 33 years (IQR 31 −36), 92% were of White ethnicity. Acceptability was high, but higher for a maternal vaccine than an infant monoclonal antibody (p<0.0001). Concerns about safety, need for more information, and number of vaccines given to infants already were common reasons for hesitancy. Lacking knowledge about RSV was associated with a lower likelihood of accepting either option (maternal vaccine: OR 0.32, 95% CI 0.16-0.68, p=0.002; infant monoclonal antibody: OR 0.35, 95% CI 0.19-0.68, p= 0.002), as was identifying as Black, Black British, African or Caribbean ethnic group, or having declined the routinely recommended antenatal vaccines.ConclusionsWhilst most parents would accept a maternal vaccine or infant monoclonal antibody to protect their infant against RSV, understanding preferences, influencing factors and concerns is essential to optimise immunisation programmes. This study highlights the information parents require to make an informed choice about RSV protection.
Time-resolved RNA-seq data reveal dynamic expressional behaviour of TALE target genes
Authors: Grau Jan , Grove René , Erkes Annett , Unger Neele , Göricke Marcel , Boch Jens 
Published: May 2024

AbstractXanthomonas oryzaebacteria infect rice (Oryza sativa) plants causing substantial harvest loss. During the infection, the bacteria translocate a collection of effector proteins into the host plant cells. This includes transcription activator-like effectors (TALEs) that act as transcriptional activators of plant genes. To understand the dynamics of TALE action during the infection, we collected RNA-seq data at different time points after the infection of rice plants with two representative pathogens of the two rice-pathogenicXanthomonas oryzaessp., namelyXan-thomonas oryzaepv.oryzaePXO83 andXanthomonas oryzaepv.oryzicolaBAI35. We observed that the induction of direct TALE target transcripts already starts 24h after the infection and is widely established after 36h, while 72h after the infection, secondary targets and downstream effects start to dominate the set of differentially expressed transcripts relative to control. Based on computational predictions of TALE targets combined with expression data, we established criteria that may help to identify direct TALE targets, which are related to expression dynamics but also shifted transcription start sites, and compiled a list of high-confidence TALE targets. Using genome-wide target predictions, we further discovered several non-coding and anti-sense transcripts that are likely induced by TALEs. Finally, we investigated different strategies to link putative secondary targets to transcription factors that are induced by TALEs during the infection.
Fostering hotel ambidexterity through knowledge-sharing culture and knowledge-sharing behavior: a study of the hospitality sector in Pakistan
Authors: Hadi Noor Ul , Sheikh Sadia Aftab 
Published: May 2024

PurposeTo paint a more comprehensive picture of organizational ambidexterity in the hotel industry, the purpose of this study is to investigate how and when to develop a dual operating system following a theoretical rationale supported by the three-stage model of creativity and organization support theory.Design/methodology/approachSurvey-based research strategy and questionnaire-based data collection techniques have been used in the current study. data was randomly collected from human resource managers of 16 four-star and five-star hotels. The 200 questionnaires were distributed, out of which 182 usable questionnaires were analyzed using “PROCESS macro”.FindingsThe findings show that the integrative moderated-mediation model fits the data well. Hence, the three-stage model of creativity and organization support theory is useful, and the numerical evidence verified its applicability in the hospitality industry. To conclude, the results of this study, when applied to the hotel industry, can do marvels by being more innovative with their services.Originality/valueMore recently, it has been found that long-term success is only achievable and can be sustained if exploitative and explorative innovations are balanced. So far, however, little is known about how to achieve organizational ambidexterity in the hospitality industry.
Continuous service-based process monitoring using Pareto analysis and start-end case diagram
Authors: Noroozian Ali 
Published: May 2024

PurposeThe purpose of this study is to offer a straightforward, cost-effective, and feasible resolution for managers to assess their processes in a live manner using the process mining technique and to identify anomalies in cases that deviate from the standard. Consequently, the findings of this research can be utilized by organizational managers, while process mining vendors can also leverage it as a feature for their solutions.Design/methodology/approachOur two-step method is designed to initially evaluate the level of standardization within the process, followed by identifying its underlying cause. These two steps are aimed at helping managers effectively evaluate their business processes. The steps are: (1). Start-End Case Diagram: This diagram allows for the evaluation of the lead time trend and identification of cases that deviate from the standard trend line in a service-based process. (2). Happy Path Analysis: Pareto law is suggested to identify the most frequent process variants.FindingsThis approach enables organizations to easily identify problematic cases and investigate bottlenecks when deviations from the standards occur.Originality/valueThe novelty of the paper lies in the introduction and utilization of the start-end case diagram, as well as the combination of this diagram with the Pareto law for the identification of happy path and root cause analysis.
Sustainable human resource management: a mixed-method analysis of the research field focusing on the visegrad countries
Authors: Piwowar-Sulej Katarzyna 
Published: May 2024

PurposeI aimed to analyze and synthesize the literature on sustainable HRM and its sub-concepts, such as green HRM and socially responsible HRM, with the focus on research conducted in the Visegrad Group (V4) countries. I posed the following research questions: (1) What are the main characteristics of sustainable HRM research in the worldwide literature? (2) What are the main characteristics of research conducted in the V4 countries? (3) Which future research directions are promising gaps to be filled by research conducted in V4 countries?Design/methodology/approachFor the purpose of this study, I applied bibliometric analysis, scientific network analysis and in-depth content analysis.FindingsThe results of the analyses of articles indexed in the Scopus database revealed that there is a growing trend in research on sustainable HRM. However, scarce research comes from the V4; scholars have conducted such studies only in Slovakia and Poland. There are five thematic clusters in the main sample, though the concept of green HRM has been explored the most. Although the keyword network analysis showed that the V4 articles focus mostly on sustainable HRM, the in-depth content analysis provided evidence that the V4 sample represented all concepts.Originality/valueThis is the first study to analyze the achievements of scientists from the V4 in this research field. It applies methodological rigor and a mixed-method approach. Moreover, it presents directions of research that go beyond the recommendations presented in the analyzed articles.
Forecasting hospital outpatient volume using an optimized medical two-stage hybrid grey model
Authors: Ren Youyang , Wang Yuhong , Xia Lin , Liu Wei , Tao Ran 
Published: May 2024

PurposeForecasting outpatient volume during a significant security crisis can provide reasonable decision-making references for hospital managers to prevent sudden outbreaks and dispatch medical resources on time. Based on the background of standard hospital operation and Coronavirus disease (COVID-19) periods, this paper constructs a hybrid grey model to forecast the outpatient volume to provide foresight decision support for hospital decision-makers.Design/methodology/approachThis paper proposes an improved hybrid grey model for two stages. In the non-COVID-19 stage, the Aquila Optimizer (AO) is selected to optimize the modeling parameters. Fourier correction is applied to revise the stochastic disturbance. In the COVID-19 stage, this model adds the COVID-19 impact factor to improve the grey model forecasting results based on the dummy variables. The cycle of the dummy variables modifies the COVID-19 factor.FindingsThis paper tests the hybrid grey model on a large Chinese hospital in Jiangsu. The fitting MAPE is 2.48%, and the RMSE is 16463.69 in the training group. The test MAPE is 1.91%, and the RMSE is 9354.93 in the test group. The results of both groups are better than those of the comparative models.Originality/valueThe two-stage hybrid grey model can solve traditional hospitals' seasonal outpatient volume forecasting and provide future policy formulation references for sudden large-scale epidemics.
Dynamic interconnections between career engagement and perceived employability among recent graduates: a latent change score modeling approach
Authors: Grosemans Ilke , Forrier Anneleen , De Cuyper Nele 
Published: May 2024

PurposeThe purpose of this paper is to examine career engagement and perceived employability during the school-to-work transition. We studied within-person changes in career engagement and perceived employability in the transition from higher education to the labor market. We investigated their dynamic reciprocal relationship to unravel whether career engagement or perceived employability is the leading indicator in the relationship in view of providing adequate support for students during the school-to-work transition.Design/methodology/approachWe conducted latent change score (LCS) analyses on a three-wave sample of 701 graduates in Flanders (Belgium). We collected data in July (right before graduation), November and May. LCS is a novel method allowing to simultaneously test change and reciprocal relationships.FindingsOur findings demonstrated how both career engagement and perceived employability changed (within-person) non-linearly during the school-to-work transition. As for their relationship, we found that perceived employability is the driving force in the relationship. Perceived employability fueled subsequent positive changes in career engagement, whereas career engagement did not lead to subsequent changes in perceived employability.Originality/valueOur study connects the career development and the graduate employability literature, and examines the school-to-work transition from preparation for the labor market to ten months after graduation. We also make an important methodological contribution, demonstrating the added value of LCS for studying employability in higher education. Our findings provide insights in how higher education institutions may support students in the school-to-work transition.
The impact of functional and service quality on perceived security in manufacturing and telecommunication services
Authors: Song Ho Jun , Shin Nina , Koo Hyun Mo , Shin Wan Seon 
Published: May 2024

PurposeThis research deals with the critical factors of quality and their significance to perceived security as an effort to build a formidable loyalty of customers in a technology driven service environment. The primary purpose of this study is to investigate the key contributing elements of functional and service quality on perceived security and to further analyze its impact on customer satisfaction and loyalty.Design/methodology/approachA hypothesized structure model is proposed and justified using the data collected in the manufacturing and telecommunication service sectors in South Korea through survey with total 647 respondents. To clarify the reliability of model and validity of the proposed hypothesis, AMOS 24.0 software was utilized. Furthermore, two moderating variables were adopted for the depth understanding.FindingsThis study reveals that service quality dominantly influences the level of perceived security due to its characteristics that are mostly formed on the stage of customer-contact activity. This study further provides a strategic methodology for manufacturing and telecommunication firms to foster sustainable growth by focusing on perceived security during the service delivery process.Originality/valueThis finding is particularly important as Ontact technology becomes increasingly critical during the COVID-19 pandemic. It is worthwhile noting that the research outcome of this study may, in turn, trigger the trust issue that need to be combined with quality in the era of Industry 4.0.
Understanding beginning teachers’ socio-ecological challenges: self-directed learning in the r/Teachers subreddit
Authors: Na Hunhui , Staudt Willet K. Bret 
Published: May 2024

Purpose
The purpose of this study is to explore beginning teachers’ diverse challenges and how these are related to self-directed professional learning through social media.

Design/methodology/approach
The authors conducted a content analysis of 2,445 “New Teacher” tagged posts shared in the r/Teachers subreddit. With 1,246 posts relevant to beginning teachers’ challenges, the authors used a socio-ecological model to analyze and categorize the challenges.

Findings
Results showed that posts reflected diverse and complex challenges. Such challenges were found to be interrelated and associated with employment status, highlighting teacher marginalization issues. Results also show that most posts sought resources or advice rather than merely complaining about their situations, meaning that beginning teachers leveraged the anonymity and shared affinity offered by r/Teachers to overcome their challenges as self-directed professional learners.

Originality/value
The current study not only highlights diverse and complex challenges faced by beginning teachers but also sheds light on how they navigate their challenges in social media spaces. This research provides unique insights into how social media, particularly an anonymous affinity space – r/Teachers, can benefit teachers’ professional growth in today’s digital era.
The commercialisation of microfinance: deploying management control to address institutional complexity
Authors: Siti Nazariah A.Z. , Siti-Nabiha A.K. , Azhar Zubir 
Published: May 2024

PurposeThe study aimed to examine the transformation of a non-profit microfinance institution (MFI) into a hybrid social enterprise, and the role of formal and informal controls in reconciling the discordance between the two conflicting (social and commercial) objectives that emerged due to the transformation.Design/methodology/approachA case study of a non-governmental MFI located in Southeast Asian country was conducted. This case study drew on the institutional logics perspective as an analytical tool to understand the complexity of change and the mobilisation of management control practices to align two conflicting goals at the core of the MFI’s organisational strategies. This study adopted the interpretive approach and relied on multiple data sources, including semi-structured interviews and documentary evidence.FindingsThe application of commercial principles in the operations of the MFI occurred in several phases. First, the MFI changed from a non-profit business model to a hybrid social enterprise, which pursued a double bottom-line strategy. The informal control practices inherent in the organisation’s culture created a high level of social awareness embedded within a social logic. In contrast, the formal control practices were directly linked to the new commercial logic. The synergy between the two logics was optimised by reinforcing formal and informal control practices.Originality/valueThis study offers insights into the role of control systems in reconciling the discordance between competing social and financial objectives within a non-governmental MFI that enjoys substantial financial and nonfinancial support from the government.