bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Substance Abuse on Domestic Violence
Authors: Alhussein Zahraa Ali Abed , Alwan Eman Hussien 
Published: June 2024

find out the relationship between drug abuse and domestic violence . descriptive study design. A sample of (50) couples were introduced. A two questionnaire self-report w used to gather data from drug users and abused women .data were gathered in 2024 between January and March The results indicate that the average age of the male is 27±4, then 24 ±4 female, are married, and (38%) were graduated from secondary school while 36% of their wives are graduated from intermediate schools. 82% of clients with substance use are working with free works while 78% of their wives are housewives. 42% of participants are within monthly income of 601000 – 900000 Iraqi dinars. 60% of wives betrayed by their clients with substance use problems. there is positive significant relationship between substance use among clients and domestic violence among their wives at p-value= .037.Among substance abuse and domestic violence are positive correlated, as shown by significant reverse correlation with p-valy67uue=. 037. Domestic abuse is prevalent and unacceptable in both lifetime and present times. Regardless of age, economic standing, or educational attainment, women will at some point in their lives become victims of abuse. Abuse of drugs increases the chance of violence. Spreading the culture of the danger of drugs and treatment from them by opening rehabilitation centers in various cities and villages Focus on protecting women and developing work to protect them from the risk of violence in coordination with community police.
Strontium Isotopic Variations of Authigenic Calcite in Clastic Strata Record Its Sediment Provenance and Fluid−Rock Interactions
Authors: Kang Xun , Tan Jingqiang , Lu Feng , Hu Ruipu , Hu Wenxuan 
Published: June 2024

Abstract
Strontium isotopes of authigenic carbonate potentially record sediment provenance, fluid sources, and fluid–rock interactions, little was studied on this topic in clastic strata. This study investigated clastic rocks containing authigenic calcite in the Lower Triassic Baikouquan Formation in the Junggar Basin, northwestern China. Mineral compositional and fluid inclusion analyses were conducted to constrain the precipitation processes of authigenic calcite, and the Sr contents and isotope ratios of the calcite were also measured. The authigenic calcite was precipitated at 80–140°C as the final product of thermochemical oxidation of hydrocarbons and thus has high Mn contents and highly negative δ13CVPDB values (as low as −70‰). The calcite also exhibits anomalously low 87Sr/86Sr values (0.704827, 0.706612), which are lower than contemporaneous seawater and published 87Sr/86Sr values of carbonate cements in clastic sediments, and also much lower than 87Sr/86Sr values (0.722027, 0.736750) of alkali feldspar in the strata. These low 87Sr/86Sr values record the low 87Sr/86Sr of the dominant rocks in the provenance area, such as volcanic rocks. During diagenesis, especially mesodiagenesis, the charging of hydrocarbon-bearing fluids promoted abundant dissolution of orthoclase in the alkali feldspar detritus, releasing radiogenic 87Sr into the pore waters, and eventually increasing the 87Sr/86Sr values in the late-stage calcite that precipitated after this reaction. This inference is consistent with the positive correlation between the calcite 87Sr/86Sr ratios and the dissolution intensity of orthoclase. In regions that do not undergo hydrocarbon-charging and where orthoclase remains stable, the lower 87Sr/86Sr ratios of the calcite generally record the provenance. For authigenic calcite associated with intense fluid–rock interactions, the higher 87Sr/86Sr ratios reflect the enhanced dissolution intensity of 87Sr-rich minerals such as orthoclase. Therefore, combined with a petrological study, Sr isotopes of authigenic carbonate in clastic sediments can trace sediment provenance and intensity of fluid–rock interactions.
Performance Assessment of Bismuth Ferrite Nanoparticles in Enhancing Oilwell Cement Properties: Implications for Sustainable Construction
Authors: Khan Fahad , Bardhan Anirudh , Kumar Praveen , Yadawa Yogendra , Sharma Shivanjali , Saxena Amit , Ranjan Amit 
Published: June 2024

Summary
Oilwell cement ensures wellbore stability and isolates zones while bearing casing load and formation pressure. Its properties, crucial in extreme downhole conditions, include compressive strength, fluid loss resistance, and durability. In the present work, bismuth ferrite nanoparticles (BFO NPs) were synthesized using the sol-gel method and used as an additive in oilwell cement. The synthesized BFO NPs were characterized using Fourier transform infrared (FTIR), X-ray diffraction (XRD), field-emission scanning electron microscope (FESEM), and dynamic light scattering (DLS) techniques to analyze the functional groups, crystalline structure, morphological features, and hydrodynamic size distribution. Tests at 70°C and 2,000 psi revealed that 1% by weight of cement (BWOC) BFO NPs increased compressive strength by ~136% and reduced fluid loss to ~64% compared with base cement. It can be conjectured that the exposed facets of BFO NPs containing oxygen act as nucleating sites that promote the ordering of the silicate tetrahedra, thereby increasing the strength and crystallinity and reducing the water loss. The experimental results confirm that the BFO NPs can improve the properties of oilwell cement slurry at high-pressure, high-temperature (HPHT) conditions. This research underscores the potential of BFO NPs as sustainable additives for optimizing oilwell cement performance under challenging HPHT conditions, paving the way for advancements in sustainable construction practices.
Role of Fracture Roughness in Fracture Surface Evolution During Acidized Corefloods of Calcareous Shales
Authors: Khan Hasan Javed , Al-Abdrabalnabi Ridha , Murtaza Mobeen , Aljawad Murtada Saleh 
Published: June 2024

Summary
During the hydraulic fracturing process, an acidic hydraulic fracturing fluid (HFF) is injected at high flow rates to break the rock and enhance its flow potential. This rock-fluid interaction induces both physical and chemical alterations on the fracture surface, resulting in the formation of a “reaction-altered zone.” Recent research has revealed that the depth of reaction penetration is minimal, and most changes occur on the fracture surface. To gain a deeper understanding of how fracture roughness affects fracture aperture change, in this work we adopt an experimental approach. Two similar samples of carbonate-rich Wolfcamp shale with calcite-filled fractures are selected. One sample is cut through the center creating a smooth fracture (SF), while the other is fractured by parting along the calcite-filled fracture, generating a rough fracture (RF). The fracture surface topography, mineral distribution, fracture aperture, and rock hardness are characterized before a reactive coreflood using an equilibrated acidic brine is conducted. The pressure drop across the core is measured, and the effluent is periodically collected and analyzed using mass spectrometry. The temporal changes in the fracture surface are observed by conducting physicochemical surface characterization after the coreflood. The results indicate that calcite dissolution is the primary chemical reaction occurring on the fracture surface, weakening it. Furthermore, this dissolution decreases the fracture roughness, which results in fracture closure and ultimately a decrease in the fracture conductivity. The most significant change in the fracture aperture is observed near the inlet. These results highlight the potential impact of fracture roughness on the mechanism of fracture evolution during acidized corefloods. Higher fracture roughness is associated with increased fines migration and a more significant overall change in fracture aperture during injection. This research provides valuable insights into the intricate processes at play during hydraulic fracturing and aids in understanding the dynamics of fracture growth in such conditions.
Horticultural in the Post-Land Grant Era: Presidential Address1
Authors: Lineberger R. Daniel 
Published: June 2024

Abstract
Horticulture as the science and industry grew in parallel with the land grant system. From its beginnings as the science of fruit and vegetable production, the discipline branched into studies of floral and nursery crop production, landscape construction and maintenance, public gardening, floral design, and the study of human—plant interactions. Always retaining a close relationship with the fundamental plant sciences, horticulturalists of the twentieth century made major contributions to the study of plant anatomy, genetics, physiology, growth and development, metabolism and plant—environment interactions.
Corpus Interpretation of English Ecological Discourse: Linguistic Regularities and Functional Features
Authors: Barkovich Aleksandr 
Published: June 2024

English-language environmental speech has its own linguistic features. Ecological discourse is a relevant, self-sufficient, and highly identical communication continuum. This article introduces a corpus analysis of the English-language environmental discourse with its linguistic patterns and functional interpretation. The texts were considered not as static linguistic objects, but as a system of functional features in speech. The English-language research material was authentic and featured various environmental issues. Corpus analysis is a popular and reliable tool for big linguistic data while the corpus-discursive methodology proved to be an effective interdisciplinary tool. It was applied to the EuroNews Green Corpus, aggregated from 506 English-language texts on environmental issues. This innovative type of corpus can be qualified as instrumentally independent. The research proved the effectiveness of universal case managers or case shells of open architecture, e.g., Sketch Engine. Not only did it manage to collect the data, but also performed quite a complex structure analysis, interpreting, and discourse modeling. Corpus linguistics is looking for qualitatively new opportunities to identify complex linguistic relations. The case study provided a comprehensive description of environmental discourse as an object of linguistic research. Based on statistic details, the authors analyzed the categories of tokens, keywords, and terms to structure them as lemmas, collocations, and n-grams, which were presented as metadata. The metadata modeling provided concordances, thesauruses, and frequency glossaries. Environmental discourse had a pronounced lexical and semantic uniqueness resulting from specific ecological terminology. However, the multidimensional corpus analysis revealed an extremely low frequency of the key concept of ecology. Thus, this corpus study of the English-language ecological discourse demonstrated a good potential for further linguistic research.
Mesothelin-Mediated Paclitaxel Phase-Shifted Nanodelivery System for Molecular Ultrasound Imaging and Targeted Therapy Potential in
Ovarian Cancer
Authors: Wan Yujie , Luo Li , Xu Xinzhi , Fu Qihuan , Li Ying , Huang Kaifeng , Zhou Hang , Li Fang 
Published: June 2024

Background:
Ovarian cancer presents a substantial risk to women's health and lives,
with early detection and treatment proving challenging. Targeted nanodelivery systems are
viewed as a promising approach to enhance the effectiveness of ovarian cancer treatment and ultrasonic
imaging outcomes.

Objective:
A phase-shifted nanodelivery system (NPs) loaded with paclitaxel (PTX) and further
conjugated with avidin (Ab) was studied, with the goal of investigating the effects of targeted nanodelivery
strategies on the in vitro therapeutic efficacy and ultrasonic imaging of ovarian cancer.
This study provides a foundation for future in vivo treatments utilizing this approach.

Methods:
PTX-NPs were prepared using the single water-in-oil (O/W) emulsion solvent evaporation
method, with avidin coupling achieved through biotin-avidin affinity. The encapsulation efficiency
and release profile of PTX were analyzed using UV spectrophotometry. The phase-shift
properties of the Ab-PTX-NPs delivery system were evaluated, and the targeting efficiency, cytotoxicity
against SKOV3 cells, and in vivo biosafety of various nanodelivery systems were assessed.

Results:
The prepared nanodelivery system showed a stable and uniform structure with a good particle
size distribution and exhibited favorable release characteristics under ultrasound exposure. In
vitro experiments revealed that the nanodelivery system displayed excellent targeting and cytotoxic
effects against SKOV3 cells, indicating the potential of the Ab-PTX-NPs delivery system for
targeted ovarian cancer therapy. In vivo safety studies demonstrated the high biosafety of the prepared
nanodelivery system.

Conclusion:
A novel nanodelivery system was developed, and the experimental results obtained
provide a solid experimental basis for further research on in vivo ultrasound molecular imaging
technology, offering new insights into targeted ultrasound molecular imaging and the treatment of
ovarian cancer.
Low Expression of GRIM-19 Correlates with Poor Prognosis in Patients with Upper Urinary Tract Urothelial Carcinoma
Authors: Tian Feng , Lv Long , Liu Zonglin , Guan Sheng , Jiang Fengze , Wang Qi , Kalvakolanu Dhan V , Jiang Sixiong , Sun Weibing 
Published: June 2024

Purpose:
This study aimed to clarify the expression of a gene associated with Retinoid-
Interferon-Induced Mortality-19 (GRIM-19) in Upper Urinary Tract Urothelial Carcinoma
(UUTUC) and its prognostic significance for UUTUC patients.

Materials and Methods:
Immunohistochemical (IHC) staining was used to determine the
GRIM-19 expression in 70 paired samples. Progression-Free Survival (PFS) and Cancer-Specific
Survival (CSS) were assessed using the Kaplan-Meier method. The independent prognostic factors
for PFS and CSS were analyzed by multivariable Cox regression models.

Results:
IHC staining showed that GRIM-19 expression was significantly decreased in UUTUC,
and its cellular location changed from being both cytoplasmic and nuclear to only cytoplasmic. Kaplan-
Meier analysis revealed that the patients with tumors expressing low GRIM-19 had a significantly
higher risk for tumor progression (P = 0.002) and cancer-specific mortality (P < 0.001)
compared to those with high GRIM-19 levels. The Cox regression showed that both GRIM-19 expression
(P = 0.025) and lymph node metastasis (LN) (P = 0.007) were independent predictors of
progression in the muscle-invasive (MIC) subgroup. GRIM-19 expressions (entire cohort: P =
0.011; MIC subgroup: P = 0.025), LN (entire cohort: P = 0.019; MIC subgroup: P = 0.007), and
progression (entire cohort: P < 0.001; MIC subgroup: P < 0.001) were independent predictors of
cancer-specific survival.

Conclusion:
Low expression of GRIM-19 in patients with UUTUC had significantly shorter PFS
or CSS compared to those with high GRIM-19-expressing tumors. High GRIM-19 expression was
also strongly associated with longer PFS in MIC patients. It indicates that GRIM-19 might serve
as a promising prognostic biomarker for UUTUC patients.
YADA - Reference Free Deconvolution of RNA Sequencing Data
Authors: Livne Dani , Snir Tom , Efroni Sol 
Published: June 2024

Introduction:
We present YADA, a cellular content deconvolution algorithm for estimating
cell type proportions in heterogeneous cell mixtures based on gene expression data. YADA utilizes
curated gene signatures of cell type-specific marker genes, either obtained intrinsically from
pure cell type expression matrices or provided by the user.

Methods:
YADA implements an accessible and extensible deconvolution framework uniquely capable
of handling marker genes alone as inputs. Adoption barriers are lowered significantly by relying
solely on literature-supported cell type-specific signatures rather than full transcriptomic profiles
from purified isolates. However, flexible inputs do not necessitate sacrificing rigor - predictions
match metrics of current methodologies through an integrated optimization scheme balancing multiple
inference algorithms. Efficiency optimizations via compiled runtimes enable rapid execution.
Packaging as an importable Python toolkit promotes community enhancement while retaining codebase
extensibility.

Results:
Validation studies demonstrate that YADA matches or exceeds the performance of current
deconvolution methods on benchmark datasets. To demonstrate the utility and enable immediate usage,
we provide an online Jupyter Notebook implementation coupled with tutorials.

Conclusion:
YADA provides an accurate, efficient, and extensible Python-based toolkit for cellular
deconvolution analysis of heterogeneous gene expression data.
Drug Delivery and Monitoring through Wearable Devices with
Microneedles in the Field of the Health Care System
Authors: Kumarswamy K.C. , Madhu B.K. , Naveen N. Raghavendra , Goudanavar Prakash S. , Purushotham K.N. 
Published: June 2024

:
Microneedles represent a revolutionary advancement in drug delivery and diagnostics,
offering a minimally invasive approach to accessing the intricate biological environment of the
human body. These micron-sized needles, typically ranging from 25 to 1000 micrometers in
length, penetrate the outermost layer of the skin, creating microchannels that facilitate the transdermal
administration of therapeutics or the extraction of interstitial fluid for analysis. This innovative
technology holds great promise for enhancing patient compliance, reducing side effects, and
improving the overall efficiency of drug delivery. Integrating microneedles with wearable devices
further amplifies their potential impact. Wearable devices provide a seamless interface for monitoring
and controlling microneedle-based systems, fostering real-time data collection and personalized
healthcare. Such devices can be designed to administer precise drug doses at predetermined
intervals, adapting treatment regimens to individual patient needs.

:
Additionally, the combination of microneedles and wearable devices enables continuous monitoring
of biomarkers through the extraction of interstitial fluid, offering a non-invasive method for
disease diagnosis and management. The review also provides a detailed overview of the mechanisms,
types, fabrication techniques, applications, and patents for integrating microneedles with
wearable devices. This symbiotic relationship between microneedles and wearables opens new
paths for patient-centric healthcare, with the potential to transform chronic disease management
and streamline therapeutic interventions. As these technologies continue to evolve, their integration
may pave the way for personalized, on-demand healthcare solutions, accompanying a new era
of patient well-being and treatment efficacy.
Elucidation of the Possible Molecular Mechanism for the Anti-Apoptotic Effect of Terpene-Rich Extract of Amomum subulatum and Coriandrum sativum against Rodent Model of Cardiotoxicity
Authors: Singh Mhaveer , Y.T. Kamal , Khan Mohammad A. , Verma Navneet , Mishra Arun K. , Ahmad Sayeed 
Published: June 2024

Background:
Spices, including Amomum subulatum and Coriander sativum, are not only popular for improving food flavour but are also accepted worldwide for their health benefits in various disorders.

Objective:
This study aimed to elucidate the possible mechanism for the anti-apoptotic effect of terpene-rich extract of Amomum subulatum and Coriandrum sativum against the rodent model of cardiotoxicity.

Methods:
Effects of standardized terpenoids-rich aqueous methanolic extract of two commonly used spices, viz. Amomum subulatum Roxb. and Coriandrum sativum Linn., were investigated on doxorubicin-induced apoptotic changes and cardiotoxicity in Wistar rats with the aim of in-vestigating the mechanism. Prior to the in vivo experiment, the extracts were subjected to quan-titative estimation of possible bioactive markers of the terpenes by employing a newly devel-oped, optimized, and validated GC-MS method along with TLC profiling.

Results:
Cardiotoxicity was evident from elevated creatinine kinase (CK-MB), lactate dehydro-genase (LDH), and malondialdehyde (MDA) levels in the toxic control group after treatment with doxorubicin (2.5mg/kg i.p. given twice a week for three weeks). Caspase-3, Tumor necrosis factor-α (TNF-α), and Interleukin-6 (IL-6) were also induced in animals treated with doxorubi-cin. Treatment with Amomum subulatum and Coriandrum sativum at the doses of 100 and 200mg/kg exhibited significant (P<0.001) reversal of CK-MB, LDH, MDA, Caspase-3, TNF-α, and IL-6 levels. This protective effect was further supported by the results of DNA gel electro-phoresis and histopathological observations.

Conclusion:
This study supports the cardioprotective role of selected spices against doxorubicin-induced cardiotoxicity through the anti-apoptotic mechanism.
The importance of clinical trial protocols
Authors: De Moraes Silva Melissa Andreia 
Published: June 2024

The International Committee of Medical Journal Editors (ICMJE) and the World Health Organization (WHO) define a clinical trial as any research that prospectively assigns participants or groups of human subjects to one or more interventions (medicines, procedures, devices, behavioral treatments, dietary supplements and diets, for example). These trials aim to evaluate the effects of interventions on human health. Prospective clinical research is essential for discovering new knowledge, improving the scientific base, solving challenges, and improving clinical practices. The basic principles for a successful researcher include interest, availability, persistence, and honesty. However, it is essential that, first of all, one has complete and detailed knowledge of scientific writing and preparation of the research protocol.
COVID-19 Health Impact: A Use Case for Syndromic Surveillance System Monitoring Based on Primary Care Patient Registries in the Netherlands
Authors: Rahmon Imme , Bosmans Mark , Baliatsas Christos , Hooiveld Mariette , Marra Elske , Dückers Michel 
Published: June 2024

Abstract

Background
The COVID-19 pandemic challenged societies worldwide. The implementation of mitigation measures to limit the number of SARS-CoV-2 infections resulted in unintended health effects.

Objective
The objective of this study is to demonstrate the use of an existing syndromic surveillance system in primary care during a first series of quarterly cross-sectional monitoring cycles, targeting health problems presented in primary care among Dutch youth since August 2021.

Methods
Aggregated data from the surveillance system of Nivel Primary Care Database were analyzed quarterly to monitor 20 health problems often reported in the aftermath of disasters and environmental incidents. Results were stratified by age (ie, 0‐4, 5‐14, and 15‐24 years), sex, and region (province). Weekly prevalence rates were calculated as the number of persons consulting their general practitioner in a particular week, using the number of enlisted persons as the denominator. Findings were compared to quarterly survey panel data, collected in the context of the Integrated Health Monitor COVID-19, and the Dutch stringency index values, indicative of the intensity of COVID-19 mitigation measures.

Results
Over time, weekly rates pointed to an increased number of consultations for depressive feelings and suicide (attempts) among youth, during and after periods with intensified domestic restrictions.

Conclusions
The results illustrate how, from a disaster health research perspective based on the COVID-19 pandemic, health consequences of pandemics could be successfully followed over time using an existing infrastructure for syndromic surveillance and monitoring. Particular areas of health concern can be defined beforehand, and may be modified or expanded during the monitoring activities to track relevant developments. Although an association between patterns and changes in the strictness of mitigation measures might seem probable, claims about causality should be made with caution.