bluuebunny/crossref_metadata_2025_split huggingface dataset:
The comparative anti-oxidant and anti-inflammatory efficacy of postbiotics and probiotics through Nrf-2 and NF-kB pathways in DSS-induced colitis model
Authors: Rezaie Niloofar , Aghamohammad Shadi , Haj Agha Gholizadeh Khiavi Elham , Khatami Shohreh , Sohrabi Aria , Rohani Mahdi 
Published: May 2024

AbstractIBD is a disorder which could be caused by oxidative stress. This investigation aims to determine if probiotics and postbiotics can control oxidative stress and inflammation and compare the effectiveness of these two probiotic and postbiotic mixtures of substances. 88 strains of Lactobacillus and Bifidobacterium were tested for antioxidant activity. Male wild-type C57BL/6 mice were divided into four experimental groups, namely high fat diet (HFD) + PBS, HFD + DSS, HFD + DSS + 109 cfu/ml of probiotics, and HFD + DSS + 109 cfu/ml of postbiotics. The phenotypical indices and pathological scores were assessed. The expression of genes related to NF-kB and Nrf2 signaling pathways and enzymes associated with oxidant/anti-oxidant activities, and proinflammatory/inflammatory cytokines were assessed. In contrast to the groups exposed to DSS, mice treated with probiotics mixture and postbiotics mixture alongside DSS displayed alleviation of DSS-induced adverse effects on phenotypical characteristics, as well as molecular indices such as the Nrf2 and NF-kB related genes, with a greater emphasis on the postbiotics component. In accordance with the findings of the present investigation, it can be inferred that even in using a high-fat dietary regimen as an inducer of oxidative stress, the emergence of inflammation can be effectively addressed through the utilization of probiotics and, more specifically, postbiotics.
Magnetic resonance imaging of tumor response to stroma-modifying pegvorhyaluronidase alpha (PEGPH20) therapy in early-phase clinical trials
Authors: Arias-Lorza Andrés M. , Costello James R. , Hingorani Sunil R. , Von Hoff Daniel D. , Korn Ronald L. , Raghunand Natarajan 
Published: May 2024

AbstractPre-clinical and clinical studies have shown that PEGPH20 depletes intratumoral hyaluronic acid (HA), which is linked to high interstitial fluid pressures and poor distribution of chemotherapies. 29 patients with metastatic advanced solid tumors received quantitative magnetic resonance imaging (qMRI) in 3 prospective clinical trials of PEGPH20: HALO-109-101 (NCT00834704), HALO-109-102 (NCT01170897), and HALO-109-201 (NCT01453153). Apparent Diffusion Coefficient of water (ADC), T1, ktrans, vp, ve, and iAUC maps were computed from qMRI acquired at baseline and ≥ 1 time point post-PEGPH20. Tumor ADC and T1 decreased, while iAUC, ktrans, vp, and ve increased, on day 1 post-PEGPH20 relative to baseline values. This is consistent with HA depletion leading to a decrease in tumor extracellular water content and an increase in perfusion, permeability, extracellular matrix space, and vascularity. Baseline parameter values predictive of pharmacodynamic responses were: ADC > 1.46 × 10−3 mm2/s (Balanced Accuracy (BA) = 72%, p < 0.01), T1 > 0.54 s (BA = 82%, p < 0.01), iAUC < 9.2 mM-s (BA = 76%, p < 0.05), ktrans < 0.07 min−1 (BA = 72%, p = 0.2), ve < 0.17 (BA = 68%, p < 0.01), and vp < 0.02 (BA = 60%, p < 0.01). A low ve at baseline was moderately predictive of response in any parameter (BA = 65.6%, p < 0.01 averaged across patients). These qMRI biomarkers are potentially useful for guiding patient pre-selection and post-treatment follow-up in future clinical studies of PEGPH20 and other tumor stroma-modifying anti-cancer therapies.
Assessment of the coupling coordination relationship between the green financial system and the sustainable development system across China
Authors: Li Chenggang , Bao Youhui , Li Yingjie , Yue Mu , Wu Liang , Mao Yufeng , Yang Tingzhang 
Published: May 2024

AbstractGreen finance (GF) is recognized as a key driver of sustainable development. While existing studies have extensively discussed the relationship between GF and the Sustainable Development Goals (SDGs), few have explored the coupling coordination relationship between GF and SDGs. In this paper, we use data from thirty Chinese provinces (municipalities and autonomous regions) from 2008–2021 to examine the degree of coupling coordination development (CCD) between GF and the SDGs systems using the CCD model. We find that most SDGs and their sub-goals exhibit a significant upward trend, except for SDG8, 14–16. GF presents a fluctuating upward trend, with a significant decline in 2010 and 2019. The CCDs between GF and SDGs and their sub-goals generally show an M-shaped upward trend in most regions, with most of them experiencing a synchronous decline in 2011–2012 and 2019. In the analysis of regional heterogeneity, the eastern region performs better in SDG8–9, the central region performs better in SDG3, 14–15, while the western region performs better in SDG7. This paper provides empirical evidence for a further in-depth understanding of the relationship between GF and SDGs, which can contribute to advancing GF development and the SDG process.
Adsorption properties of Pb(II) and Cd(II) in acid mine drainage by oyster shell loaded lignite composite in different morphologies
Authors: An Wenbo , Liu Yifan , Chen He , Sun Xueying , Wang Qiqi , Hu Xuechun , Di Junzhen 
Published: May 2024

AbstractA new idea to alleviate environmental pollution is the development of low-cost adsorbents using natural minerals and fishery wastes to treat high concentrations of heavy metal pollutants in acid mine drainage (AMD). Adsorbent morphology, adsorptive and regenerative capacity, and application potential are limiting factors for their large-scale use. Oyster shells capable of releasing alkalinity were loaded on the surface of lignite to develop two composite adsorbents with different morphologies (powdery and globular) for the treatment of AMD containing Pb(II) and Cd(II). The results show that the ability of the adsorbent to treat AMD is closely related to its morphologies. The pseudo-second-order kinetic model and the Langmuir model are suitable to describe the adsorption process of OS-M(P), and the maximum adsorption saturation capacities of Pb(II) and Cd(II) are 332.6219 mg/g and 318.9854 mg/g, respectively. The pseudo-second-order kinetic model and the Freundlich model are suitable to describe the adsorption process of OS-M(G). A synergistic result of electrostatic adsorption, neutralization precipitation, ion exchange and complex reaction is achieved in the removal of Pb(II) and Cd(II) by two morphologies of adsorbents. The regeneration times (5 times) and recovery rate (75.75%) of OS-M(G) are higher than those of OS-M(P) (3 times) and recovery rate (20%). The ability of OS-M(G) to treat actual AMD wastewater is still better than that of OS-M(P). OS-M(G) can be used as a promising environmentally friendly adsorbent for the long-term remediation of AMD. This study provides a comprehensive picture of resource management and reuse opportunities for natural mineral and fishery wastes.
DNA as a perfect quantum computer based on the quantum physics principles
Authors: Riera Aroche R. , Ortiz García Y. M. , Martínez Arellano M. A. , Riera Leal A. 
Published: May 2024

AbstractDNA is a complex multi-resolution molecule whose theoretical study is a challenge. Its intrinsic multiscale nature requires chemistry and quantum physics to understand the structure and quantum informatics to explain its operation as a perfect quantum computer. Here, we present theoretical results of DNA that allow a better description of its structure and the operation process in the transmission, coding, and decoding of genetic information. Aromaticity is explained by the oscillatory resonant quantum state of correlated electron and hole pairs due to the quantized molecular vibrational energy acting as an attractive force. The correlated pairs form a supercurrent in the nitrogenous bases in a single band $$\pi$$
π
-molecular orbital ($$\pi$$
π
-MO). The MO wave function $$(\Phi )$$

(
Φ
)

is assumed to be the linear combination of the n constituent atomic orbitals. The central Hydrogen bond between Adenine (A) and Thymine (T) or Guanine (G) and Cytosine (C) functions like an ideal Josephson Junction. The approach of a Josephson Effect between two superconductors is correctly described, as well as the condensation of the nitrogenous bases to obtain the two entangled quantum states that form the qubit. Combining the quantum state of the composite system with the classical information, RNA polymerase teleports one of the four Bell states. DNA is a perfect quantum computer.
Prediction of TKI response in EGFR-mutant lung cancer patients-derived organoids using malignant pleural effusion
Authors: Lee Sang-Hyun , Kim Kyuhwan , Lee Eunyoung , Lee Kyungmin , Ahn Kyeong Hwan , Park Hansom , Kim Yelim , Shin Soeun , Jeon Sang Youl , Hwang Yongki , Ahn Dong Hyuck , Kwon Yong-Jun , Moon Seok Whan , Moon Mi Hyoung , Kim Kyung Soo , Hyun Kwanyong , Kim Tae-Jung , Sung Yeoun Eun , Choi Joon Young , Park Chan Kwon , Kim Sung Won , Yeo Chang Dong , Sohn Hyun-Jung , Hyun You-Seok , Kim Tai-Gyu , Ku Bosung , Lim Jeong Uk , Kim Seung Joon 
Published: May 2024

AbstractPatient-derived organoids (PDOs) are valuable in predicting response to cancer therapy. PDOs are ideal models for precision oncologists. However, their practical application in guiding timely clinical decisions remains challenging. This study focused on patients with advanced EGFR-mutated non-small cell lung cancer and employed a cancer organoid-based diagnosis reactivity prediction (CODRP)-based precision oncology platform to assess the efficacy of EGFR inhibitor treatments. CODRP was employed to evaluate EGFR-tyrosine kinase inhibitors (TKI) drug sensitivity. The results were compared to those obtained using area under the curve index. This study validated this index by testing lung cancer-derived organoids in 14 patients with lung cancer. The CODRP index-based drug sensitivity test reliably classified patient responses to EGFR-TKI treatment within a clinically suitable 10-day timeline, which aligned with clinical drug treatment responses. This approach is promising for predicting and analyzing the efficacy of anticancer, ultimately contributing to the development of a precision medicine platform.
The S-component fold: a link between bacterial transporters and receptors
Authors: Partipilo Michele , Slotboom Dirk Jan 
Published: May 2024

AbstractThe processes of nutrient uptake and signal sensing are crucial for microbial survival and adaptation. Membrane-embedded proteins involved in these functions (transporters and receptors) are commonly regarded as unrelated in terms of sequence, structure, mechanism of action and evolutionary history. Here, we analyze the protein structural universe using recently developed artificial intelligence-based structure prediction tools, and find an unexpected link between prominent groups of microbial transporters and receptors. The so-called S-components of Energy-Coupling Factor (ECF) transporters, and the membrane domains of sensor histidine kinases of the 5TMR cluster share a structural fold. The discovery of their relatedness manifests a widespread case of prokaryotic “transceptors” (related proteins with transport or receptor function), showcases how artificial intelligence-based structure predictions reveal unchartered evolutionary connections between proteins, and provides new avenues for engineering transport and signaling functions in bacteria.
Nonlinear dynamics of femtosecond laser interaction with the central nervous system in zebrafish
Authors: Jun Soyeon , Herbst Andreas , Scheffter Kilian , John Nora , Kolb Julia , Wehner Daniel , Fattahi Hanieh 
Published: May 2024

AbstractUnderstanding the photodamage mechanism underlying the highly nonlinear dynamic of femtosecond laser pulses at the second transparent window of tissue is crucial for label-free microscopy. Here, we report the identification of two cavitation regimes from 1030 nm pulses when interacting with the central nervous system in zebrafish. We show that at low repetition rates, the damage is confined due to plasma-based ablation and sudden local temperature rise. At high repetition rates, the damage becomes collateral due to plasma-mediated photochemistry. Furthermore, we investigate the role of fluorescence labels with linear and nonlinear absorption pathways in optical breakdown. To verify our findings, we examined cell death and cellular responses to tissue damage, including the recruitment of fibroblasts and immune cells after irradiation. These findings contribute to advancing the emerging nonlinear optical microscopy techniques and provide a strategy for inducing precise, and localized injuries using near-infrared femtosecond laser pulses.
Confirming the theoretical foundation of steady-state microbunching
Authors: Kruschinski Arnold , Deng Xiujie , Feikes Jörg , Hoehl Arne , Klein Roman , Li Ji , Ries Markus , Chao Alexander 
Published: May 2024

AbstractSteady-State Microbunching (SSMB) has been proposed as a concept to generate coherent synchrotron radiation at an electron storage ring. SSMB promises to supply kilowatt level average power radiation in the extreme ultraviolet regime, meeting the power level demands for lithography applications that presently cannot be fulfilled by established accelerator technologies. SSMB is under theoretical and experimental study, building on a proof-of-principle (PoP) experiment at the Metrology Light Source which previously showed the viability of the idea. Here we report experimental findings from systematic studies in the ongoing SSMB PoP experiment, where microbunching is generated from an energy modulation imposed by a laser of wavelength 1064 nm. The results confirm the expected dependence of the microbunching process on modulation amplitude and show that the influence of transverse-longitudinal coupling dynamics is as predicted. This confirmation of key parts of the SSMB theory establishes a solid footing for continuing the proof-of-principle efforts towards the goal of constructing a prototype SSMB light source facility.
Phase 1 dose expansion and biomarker study assessing first-in-class tumor microenvironment modulator VT1021 in patients with advanced solid tumors
Authors: Chen Jian Jenny , Vincent Melanie Y. , Shepard Dale , Peereboom David , Mahalingam Devalingam , Battiste James , Patel Manish R. , Juric Dejan , Wen Patrick Y. , Bullock Andrea , Selfridge Jennifer Eva , Pant Shubham , Liu Joyce , Li Wendy , Fyfe Susanne , Wang Suming , Zota Victor , Mahoney James , Watnick Randolph S. , Cieslewicz Michael , Watnick Jing 
Published: May 2024

Abstract
Background
Preclinical studies have demonstrated that VT1021, a first-in-class therapeutic agent, inhibits tumor growth via stimulation of thrombospondin-1 (TSP-1) and reprograms the tumor microenvironment. We recently reported data from the dose escalation part of a phase I study of VT1021 in solid tumors. Here, we report findings from the dose expansion phase of the same study.

Methods
We analyzed the safety and tolerability, clinical response, and biomarker profile of VT1021 in the expansion portion of the phase I study (NCT03364400). Safety/tolerability is determined by adverse events related to the treatment. Clinical response is determined by RECIST v1.1 and iRECIST. Biomarkers are measured by multiplexed ion beam imaging and enzyme-linked immunoassay (ELISA).

Results
First, we report the safety and tolerability data as the primary outcome of this study. Adverse events (AE) suspected to be related to the study treatment (RTEAEs) are mostly grade 1–2. There are no grade 4 or 5 adverse events. VT1021 is safe and well tolerated in patients with solid tumors in this study. We report clinical responses as a secondary efficacy outcome. VT1021 demonstrates promising single-agent clinical activity in recurrent GBM (rGBM) in this study. Among 22 patients with rGBM, the overall disease control rate (DCR) is 45% (95% confidence interval, 0.24-0.67). Finally, we report the exploratory outcomes of this study. We show the clinical confirmation of TSP-1 induction and TME remodeling by VT1021. Our biomarker analysis identifies several plasmatic cytokines as potential biomarkers for future clinical studies.

Conclusions
VT1021 is safe and well-tolerated in patients with solid tumors in a phase I expansion study. VT1021 has advanced to a phase II/III clinical study in glioblastoma (NCT03970447).
Transition agroécologique du système alimentaire : un enjeu de santé globale
Authors: Duru Michel 
Published: May 2024

L’agriculture et l’alimentation sont au cœur de défis interdépendants : épuisement des ressources naturelles, pollutions, érosion de la biodiversité, dérèglement climatique, augmentation des maladies chroniques et infectieuses. De nouvelles approches intégratrices basées sur la santé sont nécessaires pour dépasser les approches « en silo » qui ne considèrent pas les multiples interdépendances entre la santé des humains, des animaux et l’environnement. Nous proposons le concept d’« Une seule santé » basé sur les interdépendances entre les santés humaine, animale, environnementale en distinguant pour cette dernière la santé des agroécosystèmes (échelle locale) et celle du « système Terre » (écosystèmes non cultivés, eau, atmosphère). De cette façon, il est possible de traiter explicitement des relations entre le système alimentaire, du champ à l’assiette, et les quatre domaines de santé, et ainsi de penser les changements à opérer pour relever les défis contemporains locaux et planétaires.
L’intégration culture-élevage, une opportunité pour l’élevage et la transition agroécologique des systèmes agricoles
Authors: Stark Fabien , Ryschawy Julie , Grillot Myriam , Jouven Magali , Martin Guillaume , Moulin Charles-Henri , Puech Thomas , Moraine Marc 
Published: May 2024

L’élevage, dans ses formes dites « industrielles », est aujourd’hui largement critiqué pour ses impacts environnementaux. Pour autant, d’autres formes d’élevage plus vertueuses existent, et l’élevage peut s’avérer indispensable pour répondre aux enjeux de production alimentaire, de fourniture de services écosystémiques et de dynamiques socioterritoriales, pour autant qu’il s’intègre dans un paysage agricole diversifié. L’agroécologie nous invite à mieux valoriser la diversité cultivée et élevée dans les exploitations et dans les territoires. L’intégration culture-élevage correspond aux pratiques agricoles à même d’exploiter les synergies entre composantes animales et végétales de cette diversité, à travers le bouclage des cycles de nutriments (fertilisation, alimentation) et les complémentarités fonctionnelles (lutte biologique, désherbage). Ces pratiques déployées au sein d’exploitations diversifiées et/ou entre exploitations spécialisées d’un territoire permettent ainsi de réduire la dépendance aux intrants (aliments achetés, fertilisants chimiques, phytosanitaires, carburants pour la mécanisation) et d’améliorer l’efficience d’utilisation des ressources. Elle peut également accroître la résilience en diluant les risques liés aux aléas (climatiques, économique), et améliorer la productivité du milieu par la diversité des produits. Pour autant, ces pratiques ne font pas (encore) partie du modèle agricole dominant et leur développement nécessitera de lever certains freins techniques, territoriaux et socioéconomiques qui, à défaut d’être rédhibitoires, en limitent aujourd’hui le déploiement.
Is Stimulated Thyroglobulin Before Radioiodine Therapy a Useful Tool
in Predicting Response to Initial Therapy in Patients with Differentiated
Thyroid Carcinoma?
Authors: Jaeger Fabiana , Eidt Laura Berton , Guidolin Kamille , Landenberger Giullia Menuci Chianca , Bündchen Cristiane , Golbert Lenara , Mattevi Vanessa Suñé , Meyer Erika Laurini de Souza 
Published: May 2024

AbstractThyroglobulin (Tg) is an important tool to evaluate the persistence and
recurrence risk in differentiated thyroid cancer (DTC). We aimed to evaluate the
correlation between pre-radioiodine therapy stimulated Tg (pre-RAI Tg) levels
and the first response to treatment evaluation, and to establish a cut-off
pre-RAI Tg threshold for predicting an initial excellent response. Retrospective
cohort study of DTC patients who underwent total thyroidectomy and radioiodine
therapy. Response to therapy was evaluated 6 to 24 months after initial therapy,
and patients were classified as: excellent response (ER); indeterminate response
(IndR) and incomplete response (IncR). Total patients: 166 among which 85.5%
female with mean age of 47.6 ± 13 years. The ER had a significantly lower
pre-RAI Tg in comparison to IndR (p<0.001) and IncR (p<0.001), and pre-RAI
Tg were different between the IndR and IncR (p=0.02). A cut-off pre-RAI Tg value
at 7.55ng/ml was obtained by receiver operating characteristics curve for
differentiating ER from IndR and IncR. The area under curve was 0.832 (95% CI
0.76–0.91). In multivariate analysis, ATA low-risk (RR 1.61, 95% CI 1.06–2.43,
p=0.025) and Tg below 7.55ng/ml (RR 2.17, 95% CI 1.52–3.10, p<0.001) were
associated with ER. After a median of 7.4-year follow-up, 124 (74.7%) patients
were allocated into ER, 22 (13.2%) into IndR, and 20 (12%) into IncR. In
conclusion, pre-RAI Tg predicts first evaluation of treatment response. Pre-RAI
Tg cut-off was a key predictor of initial excellent response to therapy and may
be an important tool in the follow-up of DTC patients.
A new through-the-scope clip with anchor prongs is safe and successful for a variety of endoscopic uses
Authors: Guardiola John J. , Rex Douglas K. , Thompson Christopher C. , Mosko Jeffrey , Ryou Marvin , Peetermans Joyce , Rousseau Matthew J , von Renteln Daniel 
Published: May 2024

Abstract
Background and study aims Endoscopic through-the-scope clips (TTSC) are used for hemostasis and closure. We documented the performance of a new TTSC with anchor prongs.
Patients and methods We conducted a prospective case series of the new TTSC in 50 patients with an indication for endoscopic clipping at three hospitals in the United States and Canada. Patients were followed for 30 days after the index procedure. Outcomes included defect closure and rate of serious adverse events (SAEs) related to the device or procedure.
Results Fifty patients had 56 clipping procedures. Thirty-four procedures were clipping after endoscopic mucosal resection (EMR) in the colon (33) or stomach (1), 16 after polypectomy, two for hemostasis of active bleeding, and one each for fistula closure, per-oral endoscopic myotomy mucosal closure, or anchoring a feeding tube. Complete defect closure was achieved in 32 of 33 colon EMR defects and 21 of 22 other defects. All clips were placed per labeled directions for use. In 41 patients (82.0%), prophylaxis of delayed bleeding was reported as an indication for endoscopic clipping. There were three instances of delayed bleeding. There were no device-related SAEs. The only technical difficulty was one instance of premature clip deployment.
Conclusions A novel TTSC with anchor prongs showed success in a
range of defect closures, an acceptable safety profile, and low incidence of technical
difficulties.