bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intramedullary neurenteric cyst in the spinal cord of a dog
Authors: Santifort Koen M. , Garosi Laurent , Carrera Ines , Grinwis Guy , Bergknut Niklas 
Published: February 2025

AbstractA 7‐year‐old, female, entire American Staffordshire terrier was presented for chronic progressive ambulatory monoparesis of the right pelvic limb. Magnetic resonance imaging of the thoracolumbar spinal cord revealed a well‐demarcated, rounded, slightly right‐sided intramedullary space‐occupying lesion at the level of T11–12. It was homogeneous, markedly T2‐hyperintense when compared to the spinal cord, T1‐hypointense and without contrast enhancement. Despite treatment with prednisolone (0.6 mg/kg every 24 hours), the dog deteriorated within 2 weeks to being paraplegic on the day of surgery. A hemilaminectomy was performed over T11–12 on the right, and the intramedullary localisation of the lesion was confirmed. A grey‐blueish, gelatinous, walled structure was encountered and, after myelotomy, removed piecemeal from the spinal cord with the assistance of suction and lavage. Histopathology revealed a well‐demarcated epithelial cyst consistent with a neurenteric cyst. Follow‐up 20 months after surgery revealed mild paraparesis and ataxia, with bunny hopping when running.
Review of conceptual and empirical approaches to characterize infiltration
Authors: Basset Christelle , Abou Najm Majdi , Angulo‐Jaramillo Rafael , Bagarello Vincenzo , Ghanbarian Behzad , Prima Simone Di , Iovino Massimo , Lassabatère Laurent , Stewart Ryan 
Published: February 2025

AbstractInfiltration regulates the movement and storage of water at the soil–atmosphere interface and is, therefore, a key component of many related physical and biogeochemical processes. Numerous studies have examined infiltration over the past two centuries. These efforts have resulted in the development of numerous models that capture the effects of specific soil properties and initial and boundary conditions. This proliferation of models has advanced our collective ability to understand infiltration processes but has also made it challenging for researchers to select appropriate approaches for analyzing experimental infiltration data or for conducting basic research on soil parameters like saturated hydraulic conductivity or sorptivity. Here, we aimed to reduce this uncertainty by developing a comprehensive literature review of published infiltration models, including their underlying philosophies and evolution over the years. Through this effort, we compiled and examined 138 unique infiltration models. We grouped models into two major categories, empirical and conceptual, noting that boundaries between those two categories are at times debatable. After classifying and providing a full historical retrospective of these models, we examined specific model parameters and how their usage has changed with time. We also reviewed different methods applied to estimate infiltration parameters, as well as the challenges that arise when using such methods. Finally, we proposed a framework for identifying suitable models depending on field conditions, experimental plan, and data availability.
An observational study of a circular gust front over the Yangtze Delta, China
Authors: Zhou Wenjie , Hu Wendong , Dai Jianhua , Du Puyuan , Lu Lu , Zhang Yongkai , Hao Yanqiong 
Published: February 2025

AbstractConcentric gust fronts are formed when a thunderstorm’s downdraft reaches the ground and the outflow from the cold pool spreads uniformly outwards into the surrounding warm and humid air mass. Observational evidence presented here show the case of narrow‐band echoes forming a ring around a thunderstorm. Unlike conventional gust fronts, concentric or circular gust fronts are more likely to form in subtropical high‐pressure environments, where the horizontal wind speed in the middle to lower troposphere is relatively weak, the underlying surface is uniform and the temperature gradient around the cold pool that produces the circular gust front remains largely consistent.
Treatment of landfill leachate wastewater by chemical coagulation‐flocculation, electro‐membrane bioreactor, and anaerobic hybrid system
Authors: Bilici Zeynep , Hasnaoui Abir , Chikhi Mustapha , Sillanpää Mika , Al‐Farraj Saleh , Dizge Nadir 
Published: February 2025

AbstractIn this study, the treatment of landfill leachate wastewater by chemical coagulation, an electro‐membrane bioreactor (e‐MBR), and an anaerobic hybrid system was studied. First, chemical coagulation process was applied to landfill leachate wastewater, which is referred to their high organic pollutants. Aluminum sulfate (alum), poly aluminum chloride (PAC), ferric chloride (FeCl3), and ferrous sulfate (FeSO4) were used as coagulants. After determining the coagulant type, pH optimization (6–10) and the amount of coagulant (0.5–2.5 g/l) was optimized. In the chemical coagulation‐flocculation experiments, optimum conditions were determined as 1.0 g/l alum at pH 9. At these conditions, chemical oxygen demand (COD), total phenolic contents (TPC), and color analyses were examined and 31.16%, 35.32%, and 24.42% removal efficiencies were obtained, respectively. After coagulation‐flocculation pretreatment, the e‐MBR system was applied to the wastewater to obtain further treatment. Iron (Fe) electrode and ultrafiltration membrane (UP150) were used in the e‐MBR system. 5, 10, and 20 V electric current was applied to the system and time‐dependent flux measurements were carried out. COD, TPC, and color analyses were performed in both mixed liquor and membrane permeate. The results indicated that over ˃90% removal efficiency for COD, TPC, and color was achieved when the electric current increased from 5 to 20 V. In addition, it was also observed that the membrane fouling decreased and the flux increased. Since it still did not meet the discharge criteria, the wastewater obtained from e‐MBR treatment was subjected to the anaerobic system. After 10 days of incubation, COD, TPC, and color removal were found to be 99.25%, 100%, and 99.57%, respectively.Practioner Points
The treatment of leachate wastewater by chemical coagulation, electro‐membrane bioreactor, and anaerobic hybrid system was studied.
Optimum conditions were determined as 1 g/l alum at pH 9 for chemical coagulation.
It was observed that the membrane fouling decreased and the flux increased.
COD, color, and TPC removal efficiency were found to be 99.5%, 100%, and 99.6%, respectively.
Bioaccumulation of selected metals in Lamproglena clariae Fryer, 1956 infecting Clarias gariepinus (Burchell, 1822) collected from six sampling sites along the Vaal River, South Africa
Authors: Pretorius Marilie , Gradwohl Andreas , Windisch Jakob , Jirsa Franz , Avenant‐Oldewage Annemariè 
Published: February 2025

AbstractLamproglena clariae, a gill parasite of Clarias gariepinus has previously been identified as a valuable indicator of effect for organic and metal pollution. The current study evaluates it as a bioindicator of metal accumulation by recording the concentration (mg/kg) of Mn, Fe, Zn, Se, and Sr in adult females and eggs collected at six sites along the Vaal River, South Africa. The data are compared to the metal concentrations recorded in water and sediment, and with infection variables calculated for L. clariae collected from C. gariepinus in March 2017 and October 2018. Metal concentrations in parasite samples were measured utilizing total reflection X‐ray fluorescence spectroscopy. This was the first time this method was used to measure metal concentration in L. clariae. Manganese, Fe, Cu, Se, and Sr concentrations differed between adult females and egg specimens and between the six sampling sites, following the difference in the metal concentrations in the water and sediment samples. More polluted sites had low prevalence and low abundance of L. clariae. In adult females, Mn, Fe, Cu, Zn, Se, and Sr had higher concentrations than the water at the more polluted sites. Metal concentration (Mn, Zn, Cu, and Se) was higher in adult females compared to eggs. However, the Fe concentrations were higher in eggs than in adult females. Metal concentrations in L. clariae females were generally higher than levels recorded in water and sediment samples, indicating biomagnification, and supporting the viability of L. clariae as an accumulation indicator. High concentrations of Fe in eggs suggest that Fe elimination may occur via vitellin maternal transfer to larvae.Practitioner Points
Fish ectoparasites have not received sufficient evaluation as indicators of pollution.
Lamproglena clariae bioaccumulates metals in polluted environments.
Lamproglena clariae eggs accumulate Fe to higher concentrations than the females that produce them.
High‐resolution remote sensing for quantifying vegetation structure as avian habitat
Authors: Harju Seth , Harju Tarita , Berg Jodi , Alward Richard , Cambrin Scott 
Published: February 2025

AbstractMonitoring trends in the structure and composition of vegetation structure is a critical part of land and wildlife management. Advanced tools and technologies can help reduce the cost and improve the implementation of such monitoring. Most applications of remote‐sensing technologies, however, focus on either vegetation structure reflecting habitat requirements of a single avian species or on general measures of ecosystem productivity or biodiversity. While important, these applications ignore the needs of many applied land and wildlife managers who are often legally or administratively tasked with managing landscapes for multiple avian species with divergent habitat requirements. We used current state‐of‐the‐art technologies to assess vegetation structure in a dryland riparian ecosystem and compared this structure to avian nesting habitat metrics. We demonstrated how 3‐dimensional canopy structure, including multi‐layer canopy cover, voxelized leaf area density, and habitat‐based patch‐level leaf area density, can be quantified and tied to each species' a priori known nesting habitat. We evaluated these results in light of monitoring vegetation potentially serving as nesting habitat for 3 species of management concern. We also provided directions on future monitoring to ensure that managed parcels provide suitable vegetation structure for at least some, and possibly all, of the species given their divergent habitat requirements.
The effect of C-terminal deamidation on bacterial susceptibility and resistance to modelin-5
Authors: Dennison Sarah R. , Morton Leslie H. G. , Badiani Kamal , Harris Frederick , Phoenix David A. 
Published: February 2025

Abstract
The C-terminal amide carried by antimicrobial peptides (AMPs) can play a variable role in their antibacterial action and here, this role is investigated here for the synthetic peptide modelin-5 (M5-NH2). The peptide showed potent activity against Pseudomonas aeruginosa (MLC = 5.9 µM), with strong binding to the cytoplasmic membrane (CM) (Kd = 21.5 μM) and the adoption of high levels of amphiphilic α-helical structure (80.1%) which promoted strong CM penetration (9.6 mN m−1) and CM lysis (89.0%). In contrast, Staphylococcus aureus was resistant to M5-NH2 (MLC = 139.6 µM), probably due electrostatic repulsion effects mediated by Lys-PG in the organism’s CM. These effects promoted weak CM binding (Kd = 120.6 μM) and the formation of low levels of amphiphilic α-helical structure (30.1%), with low levels of CM penetration (4.8 mN m−1) and lysis (36.4%). C-terminal deamidation had a variable influence on the antibacterial activity of M5-NH2, and in the case of S. aureus, loss of this structural moiety had no apparent effect on activity. The resistance of S. aureus to M5-NH2 isoforms appeared to be facilitated by the high level of charge carried by these peptides, as well as the density and distribution of this charge. In the case of P. aeruginosa, the activity of M5-NH2 was greatly reduced by C-terminal deamidation (MLC = 138.6 µM), primarily through decreased CM binding (Kd = 118.4 μM) and amphiphilic α-helix formation (39.6%) that led to lower levels of CM penetration (5.1 mN m−1) and lysis (39.0%).
Is synovectomy still of benefit today in total knee arthroplasty with rheumatoid arthritis?
Authors: Hernigou Philippe 
Published: February 2025

Abstract

Purpose
There is a lack of long-term data evaluating the impact of synovectomy versus no synovectomy during total knee arthroplasty (TKA) in patients with rheumatoid arthritis (RA). This study aimed to assess and compare bilateral TKA outcomes with and without synovectomy in the same patients over a similar follow-up period.

Methods
A retrospective review was conducted on 65 bilateral staged posterior-stabilized (PS) fixed-bearing TKAs (28 men, 37 women) performed by a single surgeon on RA-affected knees, with an average follow-up of 17 years (range: 15–24 years). In the first knee, synovectomy was performed during TKA, while no synovectomy for the contralateral TKA. Outcomes assessed included Knee Society scores for knee and function, radiographic findings, complications, and patellar position using the Insall-Salvati ratio.

Results
The synovectomy group had a higher rate of blood transfusion (23.3% vs. 16.6%; P < 0.01) and longer hospital stays (mean 9.60 days [95% CI: 6.56–13.63] vs. 6.51 days [95% CI: 5.50–9.52]; P < 0.001). The group without synovectomy demonstrated significantly better Knee Society Scores (89.1 vs. 80.2 points; P = 0.02) and greater range of motion (ROM) for flexion (130° vs. 102°; P = 0.01). Both groups had similar knee alignment, stability, and femoral and tibial component alignment. Patella baja was observed in six patients in the synovectomy group. Severe haematoma (n = 6) and deep infections (n = 4) were noted exclusively in the synovectomy group. Kaplan-Meier survivorship at 15 years was 81% (95% CI: 78–95) for TKA with synovectomy and 95% (95% CI: 90–100) for TKA without synovectomy.

Conclusion
Knees undergoing synovectomy during primary TKA exhibited reduced knee flexion, inferior Knee Society pain scores, and higher complication rates compared to contralateral knees without synovectomy. Omitting synovectomy in RA patients did not increase the risk of implant loosening.
New approach to busulfan dosing in infants and children based on a population pharmacokinetic analysis
Authors: Balis Frank M. , Rieger Elizabeth , Bunin Nancy J. , Gardiner JoAnn , Shaw Leslie M. , Olson Timothy S. , Milone Michael C. 
Published: February 2025

Abstract

Purpose
Apply population pharmacokinetic modeling to a single institution busulfan therapeutic drug monitoring (TDM) data set from infants and children to refine dosing methods.

Methods
One-compartment pharmacokinetic model was fit to busulfan TDM data from 328 infants and children with malignant and non-malignant diseases treated with busulfan-containing transplant conditioning regimens. Age-dependence of busulfan clearance scaled to body weight and body surface area (BSA) was compared, and busulfan AUC was simulated for a BSA-scaled dose of 100 mg/m2 combined with a BSA-banded dosing table for infants and children with a BSA < 0.5 m2.

Results
Busulfan clearance scaled to body weight is age-dependent. Clearance in children ≤ 3 years (0.234 L/[h•kg]) is higher than the typical value for the population, (0.205 L/[h•kg]), and 48% of children < 5 years have subtherapeutic busulfan AUCs after the first dose. Busulfan clearance scaled to BSA (typical value, 5.47 L/[h•m2]) is more uniform across the pediatric age span, except for infants (≤ 1 year, 4.27 L/[h•m2]). Simulated busulfan AUCs with a dose of 100 mg/m2 for patients with a BSA ≥ 0.5 m2 combined with a BSA-banded dosing table for patients with a BSA < 0.5 m2 achieved a therapeutic AUC after the first dose in 49% more patients than body weight scaled doses.

Conclusion
Our model predicts a greater proportion of children would achieve a therapeutic busulfan AUC after the first dose with a dose of 100 mg/m2/d combined with the infant dosing table for patients with a BSA < 0.5 m2 compared to body weight-scaled dosing.
The use of external fixation for the correction of recurrent clubfoot: a systematic review and meta-analysis
Authors: Vaccalluzzo Marco Simone , Testa Gianluca , Sodano Andrea , Sapienza Marco , Canavese Federico , Aloj Domenico Costantino , Caldaci Alessia , Pavone Vito 
Published: February 2025

Abstract

Background
Recurrent clubfoot (CF) remains a challenging orthopedic condition, often requiring surgical intervention due to deformity rigidity and scarring from previous treatments. External fixation, particularly the Ilizarov technique, has emerged as a promising approach to correct recurrent and complex CF deformities. However, there is considerable variability in reported results regarding success and recurrence rates.

Objective
This systematic review and meta-analysis aimed to evaluate the efficacy and safety of external fixation with a focus on success rates, recurrence rates, and complication profiles in patients treated for recurrent CF.

Methods
A systematic search of five databases (PubMed, Embase, Web of Science, ScienceDirect, Cochrane Library) was performed according to PRISMA guidelines. Studies evaluating external fixation for recurrent clubfoot and reporting quantitative data on success and recurrence rates were included. A total of 438 records were screened and 21 studies met the inclusion criteria. Data extraction was performed on demographic characteristics, treatment details, and outcomes. Meta-analysis was performed using a random effects model to pool success and recurrence rates.

Results
The review analyzed 21 studies involving 489 treated feet in 406 patients. The pooled overall success rate was 81.4% (95% CI: 74.5-88.4%), while the pooled recurrence rate was 17.7% (95% CI: 11.3-24.1%). The studies showed minimal heterogeneity (I² = 0%) in both success and recurrence rates. Complications were common, with pin tract infection being the most common (29.3%), followed by toe contractures and digital ischemia.

Conclusions
External fixation is an effective approach for recurrent CF, with satisfactory success rates. However, the risk of complications underscores the need for vigilant postoperative care. The results support the use of external fixation for complex CF recurrences, but further studies are needed.
Postpartum hemorrhage: risk factors for severe blood loss, surgical intervention and peripartum hysterectomy
Authors: Barth Emma , Klapdor Rüdiger , Brodowski Lars , Hillemanns Peter , von Kaisenberg Constantin , Dütemeyer Vivien 
Published: February 2025

Abstract

Purpose
To evaluate risk factors in patients presenting with postpartum hemorrhage (PPH) associated with severe blood loss (BL), surgical intervention or peripartum hysterectomy.

Methods
This retrospective cohort study included all patients who gave birth at the Hannover Medical School between January 2013 and August 2022 with PPH, defined as BL ≥ 500 ml after vaginal delivery and ≥ 1000 ml after cesarean section. The threshold for severe PPH was set at BL ≥ 1500 ml. Operative management included manual placental removal and/or aspiration/curettage, need for intrauterine balloon tamponade, uterine packing with a chitosan covered gauze or compression sutures. Hysterectomy as ultima ratio was observed separately.

Results
In total 20.9% of 1038 patients with PPH developed severe BL. Several risk factors were identified such as nicotine abuse (aOR 3.45, 95% CI 1.57–7.59, p = 0.002), multiparity (aOR 2.12, 95% CI 1.10–4.10, p = 0.03), uterine malformation (aOR 5.09, 95% CI 1.22–21.16, p = 0.03), c-section (aOR 3.92, 95% CI 2.59–5.92, p < 0.001), placenta praevia (aOR 2.82, 95% CI 1.2–6.63, p = 0.02), abnormal placentation (aOR 9.76, 95% CI 4.22–22.56, p < 0.001) and inversion of the uterus (aOR 16.89, 95% CI 1.62–176.12, p = 0.02). More than one third of the women had a surgical intervention. Independent risk factors for an operative management of PPH were uterus malformation (aOR 5.04, 95% CI 1.22–20.91, p = 0.03), placenta praevia (aOR 2.84, 95% CI 1.23–6.53, p = 0.01), abnormal placentation (aOR 9.78, 95% CI 4.30–22.27, p < 0.001) and c-section (aOR 4.65, 95% CI 3.14–6.89, p < 0.001). Peripartum hysterectomy occurred in 1.9% of the cases and was in addition independently associated wih preeclampsia (aOR 7.50, 95% CI 1.29–43.81, p = 0.03) and amniotic infection syndrome (aOR 12.22, 95% CI 1.92–77.90, p = 0.01).

Conclusion
PPH is a common complication in modern obstetrics and one in five patients with pathological bleeding after birth develops severe BL. There are specific risk factors associated with a BL ≥ 1500 ml, surgical intervention and peripartum hysterectomy in PPH that should be assessed by health professionals and taken into account in the management of this postpartum complication.
Vestibular paroxysmia: a systematic review
Authors: Dieterich Marianne , Brandt Thomas 
Published: February 2025

Abstract
The key symptoms of vestibular paroxysmia (VP) due to neurovascular cross-compression (classical VP) or compression of the eighth nerve by space-occupying cerebellar-pontine angle processes (secondary VP) are frequent short attacks of vertigo and dizziness with unsteadiness which last seconds to minutes. They can be accompanied by unilateral auditory symptoms such as tinnitus or hyperacusis. Head movements and hyperventilation can induce nystagmus and VP attacks that most often occur spontaneously. VP is diagnosed in 3% of patients in a tertiary vertigo care center and very rarely affects children. The mean age of first appearance is 47 to 51 years with equal sex distribution. A combination of high-resolution MRI sequences (with constructive interference in steady-state/fast imaging employing steady-state, 3D-CISS/ FIESTA) of the cerebello-pontine may support the diagnosis although the beneficial treatment with sodium channel blockers is the most reliable clinical sign for classical VP, secondary VP and idiopathic VP (without verification of a causative pathology). Because of the frequency, shortness, and audiovestibular symptomatology of the attacks, the differential diagnosis to other conditions such as paroxysmal brainstem attacks, vestibular epilepsy, rotational vertebral artery compression syndrome or “near”-narrowed internal auditory canal syndrome is only relevant in exceptional cases. However, imaging of the posterior fossa including the inner ear is mandatory to distinguish between classical, secondary and idiopathic VP forms. Randomized controlled trials for medical treatment are still needed. Practical therapy of choice is medical treatment with sodium channel blockers (carbamazepine, oxcarbazepine, lacosamide). A microsurgical decompression is effective in secondary VP but is the ultimate therapy in cases with classical or idiopathic VP when medication is not tolerated.