bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Recent Advances in Structure—Reactivity Studies of Solvent Extractants in Metal Extraction
Authors: Yuan C. Y. , Li S. S. , Yuan S. G. , Ma H. L. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Poröse Materialien im Überblick
Authors: Schüth F. 
Published: May 2010

AbstractPoröse Materialien können nach verschiedenen Kriterien klassifiziert werden. Zweckmäßig ist eine Einteilung nach Porengrößen sowie in geordnete und ungeordnete Materialien. Innerhalb dieser Klassen werden typische Beispiele vorgestellt und in ihren wesentlichen Eigenschaften skizziert.
Longitudinal functional principal component modelling via Stochastic Approximation Monte Carlo
Authors: Martinez Josue G. , Liang Faming , Zhou Lan , Carroll Raymond J. 
Published: May 2010

AbstractThe authors consider the analysis of hierarchical longitudinal functional data based upon a functional principal components approach. In contrast to standard frequentist approaches to selecting the number of principal components, the authors do model averaging using a Bayesian formulation. A relatively straightforward reversible jump Markov Chain Monte Carlo formulation has poor mixing properties and in simulated data often becomes trapped at the wrong number of principal components. In order to overcome this, the authors show how to apply Stochastic Approximation Monte Carlo (SAMC) to this problem, a method that has the potential to explore the entire space and does not become trapped in local extrema. The combination of reversible jump methods and SAMC in hierarchical longitudinal functional data is simplified by a polar coordinate representation of the principal components. The approach is easy to implement and does well in simulated data in determining the distribution of the number of principal components, and in terms of its frequentist estimation properties. Empirical applications are also presented. The Canadian Journal of Statistics 38: 256–270; 2010 © 2010 Statistical Society of Canada
Cancer of the esophagus and esophagogastric junction
Authors: Rice Thomas W. , Rusch Valerie W. , Ishwaran Hemant , Blackstone Eugene H. ,   for the Worldwide Esophageal Cancer Collaboration
Published: May 2010

AbstractBACKGROUND:Previous American Joint Committee on Cancer/International Union Against Cancer (AJCC/UICC) stage groupings for esophageal cancer have not been data driven or harmonized with stomach cancer. At the request of the AJCC, worldwide data from 3 continents were assembled to develop data‐driven, harmonized esophageal staging for the seventh edition of the AJCC/UICC cancer staging manuals.METHODS:All‐cause mortality among 4627 patients with esophageal and esophagogastric junction cancer who underwent surgery alone (no preoperative or postoperative adjuvant therapy) was analyzed by using novel random forest methodology to produce stage groups for which survival was monotonically decreasing, distinctive, and homogeneous.RESULTS:For lymph node‐negative pN0M0 cancers, risk‐adjusted 5‐year survival was dominated by pathologic tumor classification (pT) but was modulated by histopathologic cell type, histologic grade, and location. For lymph node‐positive, pN+M0 cancers, the number of cancer‐positive lymph nodes (a new pN classification) dominated survival. Resulting stage groupings departed from a simple, logical arrangement of TNM. Stage groupings for stage I and II adenocarcinoma were based on pT, pN, and histologic grade; and groupings for squamous cell carcinoma were based on pT, pN, histologic grade, and location. Stage III was similar for histopathologic cell types and was based only on pT and pN. Stage 0 and stage IV, by definition, were categorized as tumor in situ (Tis) (high‐grade dysplasia) and pM1, respectively.CONCLUSIONS:The prognosis for patients with esophageal and esophagogastric junction cancer depends on the complex interplay of TNM classifications as well as nonanatomic factors, including histopathologic cell type, histologic grade, and cancer location. These features were incorporated into a data‐driven staging of these cancers for the seventh edition of the AJCC/UICC cancer staging manuals. Cancer 2010. © 2010 American Cancer Society.
Special Issue: Concurrency and Computation: Practice and Experience from the Microsoft eScience Workshop
Authors: Tolle Kristin M. , Hey Anthony J. G. 
Published: May 2010

AbstractFacilitating time to discovery by scientists through computing is an idea that has been around for a significant amount of time. Often, however, domain scientists and computer scientists work in parallel rather than in collaboration with one another. It has been a goal of this workshop (the fifth of its kind) to showcase the examples of such collaborations or tools that enable these collaborations to flourish. This editorial provides an overview of papers requested from a sampling of applied scientific collaborations that were presented at the 2008 Microsoft eScience Workshop. Copyright © 2010 John Wiley & Sons, Ltd.
An optimal multimedia object allocation solution in multi‐powermode storage systems
Authors: Jin Yingwei , Li Keqiu 
Published: May 2010

AbstractGiven a set of multimedia objectsR={o1,o2, …,ok} each of which has a set of multiple versionsoi.v={Ai.0,Ai.1, …,Ai.m},i=1, 2, …,k, there is a problem of distributing these objects in a server system so that user requests for accessing specified multimedia objects can be fulfilled with the minimum energy consumption and without significant degrading of the system performance. This paper considers the allocation problem of multimedia objects in multi‐powermode storage systems, where the objects are distributed among multi‐powermode storages based on the access pattern to the objects. We design an underlying infrastructure of storage system and propose a dynamic multimedia object allocation policy based on the designed infrastructure, which integrate and prove the optimality of the proposed policy. Copyright © 2010 John Wiley & Sons, Ltd.
Two‐dimensional difference fluorescence gel electrophoresis to verify the scale‐up of a non‐affinity‐based downstream process for isolation of a therapeutic recombinant antibody
Authors: Grzeskowiak Julita K. , Tscheliessnig Anne , Wu Ming Wei , Toh Poh Choo , Chusainow Janet , Lee Yih Yean , Wong Niki , Jungbauer Alois 
Published: May 2010

AbstractFor therapeutic antibody production Protein A chromatography is often replaced by non‐affinity‐based purification sequences, which are considered as more economical. 2‐D DIGE was applied for evaluation of scale‐up of non‐affinity based process of a humanized monoclonal antibody, anti‐Rh(D) IgG1, in comparison with other conventional analytical methods, like SDS‐PAGE, Western blot, or SEC. Due to a high sensitivity of this technique (125 pg protein/spot) and high dynamic range of five orders of magnitude, low molecular weight impurities were detected in purified samples. Cation exchange chromatography was efficient capture step for IgG1 purification in laboratory and pilot scale. The differences between samples after first purification step in laboratory and pilot scale were compensated with second purification step where almost the same protein pattern was observed. 2‐D DIGE is a helpful tool for monitoring of purification effects and for scale‐up verification of downstream processes.
Successive multiple ionic polymer layer coated capillaries in the separation of proteins – Recombinant allergen variants as a case study
Authors: Weinbauer Martin , Stutz Hanno 
Published: May 2010

AbstractA successive multiple ionic polymer layer (SMIL) coating consisting of two pairs of poly(diallyldimethylammonium chloride) and dextran sulfate (DS) layers was applied for the separation of recombinant products of the major birch pollen allergen Betula verrucosa (Bet v 1a). The combination with volatile ammonium bicarbonate buffer at pH 6.70 offers the possibility for future MS hyphenation. The negative net charge of allergens required DS as terminal SMIL layer. The EOF was accelerated from 3.17×10−8 m2 V−1 s−1 in uncoated to 4.52×10−8 m2 V−1 s−1 in SMIL capillaries. Fresh prepared SMIL capillaries showed slight EOF acceleration due to gradual re‐organization of SMIL structure until stabilization was achieved. Dry storage of SMIL capillaries prevented fluctuations in EOF and migration times and improved coating durability. However, the gradual reconstitution of entangled SMIL layers affected efficiency, but was cured by a 10 mmol/L NaOH rinsing step. Durability of SMIL capillaries in MS‐applicable dimension was confirmed for > 70 runs and in total 42 h of voltage application with average intra‐day precision of 0.22 and 0.79% and inter‐day‐precision of 0.91 and 1.17% for migration times of EOF and Bet v 1a, respectively. Final SMIL coating allowed for the separation of Bet v 1a, a hypoallergenic isoform and carbamylated variants with 150 000–685 000 plates.
Characterizing acceleration spikes due to stiffness changes in nonlinear systems
Authors: Wiebe Lydell , Christopoulos Constantin 
Published: May 2010

AbstractRecent studies have reported very large accelerations after stiffness changes in nonlinear systems, particularly self‐centering systems. Some have attributed these accelerations to numerical modelling choices and have assumed that they could be eliminated if the modelling were refined. Others have concluded that self‐centering systems generally have much larger peak accelerations than more traditional systems. This paper demonstrates that accelerations at changes in stiffness are caused by physical phenomena but may be amplified by modelling decisions. This is done by examining the response of a two‐degree‐of‐freedom system after a change in stiffness and by developing a closed‐form mathematical model to characterize this response. The equation shows that acceleration spikes should be expected near small masses and near nonlinear springs that are initially nearly rigid, particularly when those springs change from low stiffness to high stiffness while moving at a high velocity. These acceleration spikes depend on system properties that are often not known precisely, so without physical testing, analytical estimates of the accelerations that occur in nonlinear systems after stiffness changes should be treated with skepticism. Copyright © 2010 John Wiley & Sons, Ltd.
ON‐FARM EVALUATION OF FERTILIZER BRIQUETTES AND LOW‐COST DRIP IRRIGATION FOR SMALLHOLDER VEGETABLE PRODUCTION IN CAMBODIA
Authors: Bhattarai S. P. , Palada M. C. , Midmore D. J. , Wu D. , Salas R. 
Published: May 2010

ABSTRACTThe performance of low cost drip irrigation (LCDI) compared to hand watering (HW), as well as NPK fertilizer briquette deep placement (FBDP) compared to conventional compound fertilizer (CCF), for vegetable production was evaluated. Yield and water use efficiency (WUE) increased significantly with LCDI compared to HW on cucumber (13 and 41%), sponge gourd (85 and 129%), eggplant (38 and 113%), bitter gourd (121 and 35%) and long bean (5 and 27%) respectively. Yield and WUE of cucumber (22 and 25%) and long bean (9% and 12%) increased with FBDP compared to CCF. Net income due to FBDP was greater by 24 and 14% for cucumber and long bean, respectively, compared to CCF. The number of man‐days employed for irrigation increased six times in HW compared to LCDI. Net return with LCDI was greater by 52% compared to HW and varied from 4 to 121% between the crops. Combined over two trials, yield and WUE increased by 37% (5.589 vs 4.065 Mg ha−1) and 123% (4.28 vs 1.916 Mg ML−1) respectively, with less applied water in LCDI compared to HW (1.687 vs 2.78 ML ha−1). LCDI and FBDP can significantly improve yield, WUE and profitability of the small‐scale vegetable growers in Cambodia. Copyright © 2010 John Wiley & Sons, Ltd.
Late stimulation of the sphenopalatine‐ganglion in ischemic rats: Improvement in N‐acetyl‐aspartate levels and diffusion weighted imaging characteristics as seen by MR
Authors: Bar‐Shir Amnon , Shemesh Noam , Nossin‐Manor Revital , Cohen Yoram 
Published: May 2010

AbstractPurpose:To assess, by MR spectroscopy (MRS) and diffusion weighted imaging (DWI), the ability of electrical stimulation of the sphenopalatine ganglion (SPG) to augment stroke recovery in transient middle cerebral artery occluded (t‐MCAO) rats, when treatment is started 18 ± 2 h post‐occlusion.Materials and Methods:1H‐MRS imaging (1H‐MRSI) and DWI were used to evaluate ischemic brain tissue after SPG stimulation in rats subjected to 2 h of t‐MCAO. Rats were examined by 1H‐MRSI, DWI, and behavioral tests at 16 ± 2 h, 8 days, and 28 days post‐MCAO.Results:N‐Acetyl‐aspartate (NAA) levels of the stimulated and control rats were the same 16 ± 2 h post‐MCAO (0.52 ± 0.03, 0.54 ± 0.03). At 28 days post‐occlusion, NAA levels were significantly higher in the treated group (0.60 ± 0.04) compared with those of the untreated animals (0.50 ± 0.04; P < 0.05). This effect was more pronounced for regions with low NAA values (0.16 ± 0.03) that changed to 0.32 ± 0.03 (P = 0.04) for the treated group and to 0.10 ± 0.03 (P = 0.20) for the controls. DWI data showed better ischemic tissue condition for the treated rats, but the measured parameters showed only a trend of improvement. The MR results were corroborated by behavioral examinations.Conclusion:Our findings suggest that SPG stimulation may ameliorate MR tissue characteristics following t‐MCAO even if treatment is started 18 h post‐occlusion. J. Magn. Reson. Imaging 2010;31:1355–1363. © 2010 Wiley‐Liss, Inc.
Prostate cancer vs. post‐biopsy hemorrhage: Diagnosis with T2‐ and diffusion‐weighted imaging
Authors: Rosenkrantz Andrew B. , Kopec Martin , Kong Xiangtian , Melamed Jonathan , Dakwar George , Babb James S. , Taouli Bachir 
Published: May 2010

AbstractPurpose:To assess the value of quantitative T2 signal intensity (SI) and apparent diffusion coefficient (ADC) to differentiate prostate cancer from post‐biopsy hemorrhage, using prostatectomy as the reference.Materials and Methods:Forty‐five men with prostate cancer underwent prostate magnetic resonance imaging (MRI), including axial T1‐weighted imaging (T1WI), T2WI, and single‐shot echo‐planar image (SS EPI) diffusion‐weighted imaging. Two observers measured, in consensus, normalized T2 signal intensity (SI) (nT2, relative to muscle T2 SI), ADC, and normalized ADC (nADC, relative to urine ADC) on peripheral zone (PZ) tumors, benign PZ hemorrhage, and non‐hemorrhagic benign PZ. Tumor maps from prostatectomy were used as the reference. Mixed model analysis of variance was performed to compare parameters among the three tissue classes, and Pearson's correlation coefficient was utilized to assess correlation between parameters and tumor size and Gleason score. Receiver‐operating characteristic (ROC)‐curve analysis was used to determine the performance of nT2, ADC, and nADC for diagnosis of prostate cancer.Results:nT2, ADC, and nADC were significantly lower in tumor compared with hemorrhagic and non‐hemorrhagic benign PZ (P < 0.0001). There was a weak but significant correlation between ADC and Gleason score (r = −0.30, P = 0.0119), and between ADC and tumor size (r = −0.40, P = 0.0027), whereas there was no correlation between nT2 and Gleason score and tumor size. The areas under the curve to distinguish tumor from benign hemorrhagic and non‐hemorrhagic PZ were 0.97, 0.96, and 0.933 for nT2, ADC, and nADC, respectively.Conclusion:Quantitative T2 SI and ADC/nADC values may be used to reliably distinguish prostate cancer from post‐biopsy hemorrhage. J. Magn. Reson. Imaging 2010;31:1387–1394. © 2010 Wiley‐Liss, Inc.
Embryonal sarcoma of the liver in an adult mimicking complicated hepatic cyst: MRI findings
Authors: Tsukada Akira , Ishizaki Yoichi , Nobukawa Bunsei , Kawasaki Seiji 
Published: May 2010

AbstractRadiologically, embryonal sarcoma reveals a characteristic spectrum of both solid and cystic features. However, MRI is sometimes unable to reveal the solid components. Here, we describe a case in which intracystic hemorrhage revealed a solid mural nodule obscured with the cystic lesion. Knowledge of this feature is helpful when making a prospective diagnosis of this important, albeit rare, hepatic malignancy. J. Magn. Reson. Imaging 2010;31:1477–1480. © 2010 Wiley‐Liss, Inc.
Human antibody responses to bovine (Newbury‐2) norovirus (GIII.2) and association to histo‐blood group antigens
Authors: Vildevall Malin , Grahn Ammi , Oliver Stefan. L. , Bridger Janice C. , Charpilienne Annie , Poncet Didier , Larson Göran , Svensson Lennart 
Published: May 2010

AbstractSerum antibodies to bovine norovirus have been found recently in about 22% of humans. Whether this prevalence reflects limited virulence properties of the virus or that inherited host factors provide protection against bovine norovirus infection in humans remains to be established. To investigate whether histo‐blood group antigens correlate with the presence of bovine norovirus (GIII.2) antibody, plasma (n = 105) from Swedish blood donors, genotyped and phenotyped for secretor, Lewis and ABO, were tested and compared for the frequency of IgG antibody and antibody titer to Bo/Newbury2/76/UK. In total, 26.7% (28/105) of Swedish blood donors were antibody‐positive. Two non‐secretors (2/21, 9.5%) were antibody‐positive compared with 26/84 (31%) secretors (P = 0.047). While no statistically significant correlation was found between the frequency of antibodies to bovine norovirus and different ABO blood groups, individuals with blood type B presented the highest frequency of antibodies (37.5%) compared with 0–30% among other blood groups. Individuals with Le(a−b+) had not only higher frequency of antibodies (31.3%) compared with Le(a+b−) (11%) (P = 0.068) but also higher antibody titer (P = 0.085) although this was not significant statistically. No detectable cross‐reaction between bovine GIII.2 and human GII.3 NoV VLP was found with human and animal sera. The results of this study suggest that bovine norovirus infections occur in Sweden and that secretor status but not ABO blood groups is a possible risk factor for infection. J. Med. Virol. 82: 1241–1246, 2010. © 2010 Wiley‐Liss, Inc.
Prediction of the response to peg‐interferon‐alfa in patients with HBeAg positive chronic hepatitis B using decline of HBV DNA during treatment
Authors: Hansen Bettina E. , Buster Erik H.C.J. , Steyerberg Ewout W. , Lesaffre Emmanuel , Janssen Harry L.A. 
Published: May 2010

AbstractPeginterferon (PEG‐IFN) results in HBeAg loss combined with virologic response in only a minority of patients with HBeAg positive chronic hepatitis B. Baseline predictors of response to PEG‐IFN include HBV‐genotype, pre‐treatment HBV DNA levels, and ALT. The aims of this study were to develop a model, which improves the baseline prediction of response to PEG‐IFN for individual patients by including early HBV DNA measurements during treatment and to establish an early indication for cessation of treatment. One hundred thirty‐six patients treated with PEG‐IFN were included in the study. Response was defined as loss of HBeAg and HBV DNA <10,000 copies/ml at 26 weeks post‐treatment. Logistic regression analysis techniques were used to develop a dynamic prediction model with HBV DNA during the first 32 weeks of therapy. An early clinically useful rule for dis(continuation) of treatment was identified with a grid of cut‐off values of HBV DNA decline during treatment. Adding HBV DNA decline to baseline prediction increased c‐statistics from 0.846 to 0.857, 0.855 to 0.866 at weeks 4, 12, and 24. A HBV DNA decline of at least 2 log10 within 24 weeks was strongly associated with response when added to the baseline prediction model: OR 5.7 (95% CI: 1.70–20.0; P = 0.004). A dynamic model including HBV DNA decline during treatment provides more accurate predictions of response to PEG‐IFN. The model strongly supports individual decision making on treatment (dis)continuation in patients with HBeAg positive chronic hepatitis B. It is recommended that PEG‐IFN treatment is stopped by 24 weeks if HBV DNA declined <2 log10. J. Med. Virol. 82: 1135–1142, 2010. © 2010 Wiley‐Liss, Inc.
Detection of sapoviruses and noroviruses in an outbreak of gastroenteritis linked genetically to shellfish
Authors: Iizuka Setsuko , Oka Tomoichiro , Tabara Kenji , Omura Tamaki , Katayama Kazuhiko , Takeda Naokazu , Noda Mamoru 
Published: May 2010

AbstractNorovirus (NoV) and sapovirus (SaV) are important pathogens of human gastroenteritis. Compared to NoV, the transmission route of SaV is unclear. An outbreak of gastroenteritis occurred at a restaurant in June 2008, and SaV and NoV were detected in fecal specimens from 17 people who ate at the restaurant and one asymptomatic food handler and also in stripped shellfish and liquids remaining in the shellfish packages by reverse transcription‐polymerase chain reaction (RT‐PCR) and/or real‐time RT‐PCR. Nucleotide sequencing analysis of the RT‐PCR products corresponding to the partial capsid region revealed 99.3–100% identities for SaV and 98.6–99.3% identities for NoV among the digestive diverticulum of the frozen stripped shellfish (Ruditapes philippinarum), “Asari,” the package liquid, and feces from symptomatic or asymptomatic guests. These results suggested a link between the consumption of contaminated shellfish and clinical features in the patients. While the transmission of NoV by shellfish has been reported, this report shows that SaV can also be transmitted by shellfish. J. Med. Virol. 82: 1247–1254, 2010. © 2010 Wiley‐Liss, Inc.
Kinetics of cytomegalovirus (CMV) pp65 and IE‐1‐specific IFNγ CD8+ and CD4+ T cells during episodes of viral DNAemia in allogeneic stem cell transplant recipients: Potential implications for the management of active CMV infection
Authors: Tormo Nuria , Solano Carlos , Benet Isabel , Nieto José , de la Cámara Rafael , Garcia‐Noblejas Ana , Clari María Ángeles , Chilet Marifina , López Javier , Hernández‐Boluda Juan Carlos , Remigia María José , Navarro David 
Published: May 2010

AbstractThe dynamics of CMV pp65 and IE‐1‐specific IFNγ‐producing CD8+ (IFNγ CD8+) and CD4+ (IFNγ CD4+) T cells and CMV DNAemia were assessed in 19 pre‐emptively treated episodes of active CMV infection. Peripheral counts of IFNγ CD8+ and IFNγ CD4+ T cells inversely correlated with CMV DNAemia levels (P = <0.001 and P = 0.003, respectively). A threshold value of 1.3 cells/µl predicting CMV DNAemia clearance was established for IFNγ CD8+ T cells (PPV, 100%; NPV, 93%) and for IFNγ CD4+ T cells (PPV, 100%; NPV, 75%). Undetectable T‐cell responses were usually observed at the time of initiation of pre‐emptive therapy. Either a rapid (within 7 days) or a delayed (median 31 days) expansion of both T‐cell populations concomitant with CMV DNAemia clearance was observed in 5 and 8 episodes, respectively. An inconsistent or a lack of expansion of both T‐cell subsets was related to a persistent CMV DNAemia. Robust and maintained CMV‐specific T‐cell responses after CMV DNAemia clearance and cessation of antiviral therapy were associated with a null incidence of relapsing infections at least during the following month. Data obtained in the present study may be helpful in the design of therapeutic strategies for the management of active CMV infections in the allo‐SCT recipient. J. Med. Virol. 82: 1208–1215, 2010. © 2010 Wiley‐Liss, Inc.
The role of surgery in the treatment of gastric cancer
Authors: Shi Yingqiang , Zhou Ye 
Published: May 2010

AbstractDuring the past decades, despite considerable improvements in the management of gastric cancer, surgery reamains the main curative treatment. However, there is still debate about the extent of gastrectomy and lymphadenectomy, multivisceral resection, the requirement for reoperation for specimens with positive margins, the selection of neoadjuvant treatment and the management strategy of early gastric cancer. This review is to evaluate the above issues based on the reported prospective and retrospective studies. J. Surg. Oncol. 2010; 101:687‐692. © 2010 Wiley‐Liss, Inc.