bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the Role of Locus Coeruleus Degeneration in Essential Tremor and Parkinson’s Disease with Sleep Disorders
Authors: Liu Sicheng , Zhou Cheng , Fang Yuelin , Zhu Bingting , Wu Haoting , Wu Chenqing , Guo Tao , Wu Jingjing , Wen Jiaqi , Qin Jianmei , Chen Jingwen , Duanmu Xiaojie , Tan Sijia , Guan Xiaojun , Xu Xiaojun , Zhang Minming , Zhang Baorong , Zhao Guohua , Yan Yaping 
Published: May 2024

Background: Previous studies have demonstrated the importance of the locus coeruleus (LC) in sleep-wake regulation. Both essential tremor (ET) and Parkinson’s disease (PD) share common sleep disorders, such as poor quality of sleep (QoS). LC pathology is a feature of both diseases. A question arises regarding the contribution of LC degeneration to the occurrence of poor QoS. Objective: To evaluate the association between LC impairment and sleep disorders in ET and PD patients. Methods: A total of 83 patients with ET, 124 with PD, and 83 healthy individuals were recruited and divided into ET/PD with/without poor QoS (Sle/NorET and Sle/NorPD) subgroups according to individual Pittsburgh Sleep Quality Index (PSQI) score. Neuromelanin-sensitive magnetic resonance imaging (NM-MRI) and free-water imaging derived from diffusion MRI were performed. Subsequently, we evaluated the association between contrast-to-noise ratio of LC (CNRLC) and free-water value of LC (FWLC) with PSQI scores in ET and PD groups. Results: CNRLC was significantly lower in ET ( p = 0.047) and PD ( p = 0.018) than in healthy individuals, whereas no significant difference was found in FWLC among the groups. No significant differences were observed in CNR/FWLC between patients with/without sleep disorders after multiple comparison correction. No correlation was identified between CNR/FWLC and PSQI in ET and PD patients. Conclusions: LC degeneration was observed in both ET and PD patients, implicating its involvement in the pathophysiology of both diseases. Additionally, no significant association was observed between LC integrity and PSQI, suggesting that LC impairment might not directly relate to overall QoS.
Effects of Continuous Dopaminergic Stimulation on Parkinson’s Disease Gait: A Longitudinal Prospective Study with Levodopa Intestinal Gel Infusion
Authors: Imbalzano Gabriele , Artusi Carlo Alberto , Ledda Claudia , Montanaro Elisa , Romagnolo Alberto , Rizzone Mario Giorgio , Bozzali Marco , Lopiano Leonardo , Zibetti Maurizio 
Published: May 2024

Background: Gait issues, including reduced speed, stride length and freezing of gait (FoG), are disabling in advanced phases of Parkinson’s disease (PD), and their treatment is challenging. Levodopa/carbidopa intestinal gel (LCIG) can improve these symptoms in PD patients with suboptimal control of motor fluctuations, but it is unclear if continuous dopaminergic stimulation can further improve gait issues, independently from reducing Off-time. Objective: To analyze before (T0) and after 3 (T1) and 6 (T2) months of LCIG initiation: a) the objective improvement of gait and balance; b) the improvement of FoG severity; c) the improvement of motor complications and their correlation with changes in gait parameters and FoG severity. Methods: This prospective, longitudinal 6-months study analyzed quantitative gait parameters using wearable inertial sensors, FoG with the New Freezing of Gait Questionnaire (NFoG-Q), and motor complications, as per the MDS-UPDRS part IV scores. Results: Gait speed and stride length increased and duration of Timed up and Go and of sit-to-stand transition was significantly reduced comparing T0 with T2, but not between T0-T1. NFoG-Q score decreased significantly from 19.3±4.6 (T0) to 11.8±7.9 (T1) and 8.4±7.6 (T2) (T1-T0 p = 0.018; T2-T0 p < 0.001). Improvement of MDS-UPDRS-IV (T0-T2, p = 0.002, T0-T1 p = 0.024) was not correlated with improvement of gait parameters and NFoG-Q from T0 to T2. LEDD did not change significantly after LCIG initiation. Conclusion: Continuous dopaminergic stimulation provided by LCIG infusion progressively ameliorates gait and alleviates FoG in PD patients over time, independently from improvement of motor fluctuations and without increase of daily dosage of dopaminergic therapy.
Exploring the Experiences and Perceptions of Young People’s Recreational Nitrous Oxide Use
Authors: Walter Hannah , Cameron Jacqui , Simpson Helen , Kor Kenny , MacLean Sarah , Allan Julaine 
Published: May 2024

_INTRODUCTION. _This exploratory study investigated the experiences and perceptions of young people who use N2O recreationally. This is the first qualitative research conducted in Australia with young people investigating this topic in detail. The aim of this study was to explore young people's perceptions, motives, and experiences of N2O use by exploring the positive and negative effects of N2O, motives for use, practices and methods, and suggested advice, to help defines targeted harm reduction messages.

_METHODS. _Participants were recruited via hard copy posters, social media advertisements, and snowball sampling. Seven in-depth semi-structured interviews were conducted with young people aged between 18-25 years who had used N2O on at least ten occasions. The interview transcripts were analysed thematically. The study was completed in accordance with COREQ criteria for qualitative research.

_RESULTS. _The findings identified four overarching themes about N2O use, _1) The nature of N2O use; 2) The appeal of N2O; 3) Influences on N2O use; and 4) Perception of risk and harms of N2O use._

_DISCUSSION. _The findings indicated that perception of N2O harm was low amongst the young people in this study. The discussion identified three core factors that underpin N2O consumption: _1) Social influences; 2) Other substances and 3) Accessibility._

_CONCLUSION. _Young people in the study described their experiences as being largely pleasurable. However, several identified negative impacts although harms were primarily disregarded. Exploration of N2O effects alongside other substance use highlighted how N2O is a unique substance and should be considered as such when developing harm reduction strategies.
COLONIALIDAD DEL PODER Y CONSTRUCCIÓN DE LA SUBJETIVIDAD ÉTNICO-RACISTA: FUNDAMENTO OCULTO DE LA VIOLENCIA
Authors: Lora Cam Jorge 
Published: May 2024

La larga tradición colonial de la negación del otro -indio, asiático, africano, mestizo, pagano, marginal, excluido, mujer, homosexual- quien es clasificado, diferenciado, desvalorizado, ubicado y manipulado por los explotadores, bajo el dominio de las ideas de razón, civilización y progreso, con el neoliberalismo se intensifica a nivel global provocando un movimiento dialéctico entre la desidentidad y la resistencia. La intersubjetividad colonial es aprovechada por las clases dominantes y, al mismo tiempo, los aún débiles sujetos de la resistencia insertan en sus agendas de lucha y utopías anticoloniales el combate por la dignidad étnico-clasista.
PODER Y REPRESENTACIÓN: ESE ESTADO QUE LLEVAMOS DENTRO
Authors: Zibechi Raúl 
Published: May 2024

En el artículo se plantea el problema del poder a partir de la lucha social, resaltando un lado poco explorado de la misma: la dominación simbólica que la ha constituido. La internalización de formas culturales de dominación por parte de los sujetos sociales de orientación radical ha sido un factor que puede ayudar a explicar el fracaso de los movimientos que se propusieron transformar la realidad de la modernidad capitalista. Se señala cómo ciertos movimientos sociales actuales de gran importancia en América Latina han comenzado a exhibir formas de organización que cuestionan la cultura vertical y represiva de una izquierda de vocación estatal, lo cual es parte de un complejo proceso de elaboración de una subjetividad antagónica diferente y un nuevo sujeto.
¿CAMBIAR EL MUNDO SIN TOMAR EL PODER?
Authors: Fernández Buey Francisco 
Published: May 2024

Cambiar el mundo sin tomar el poder no es un libro sobre cómo cambiar el mundo en que vivimos. Y menos aún un libro sobre cómo hacerlo sin tomar el poder. Tampoco es un libro que esté específicamente dedicado a analizar lo que figura en él como subtítulo: el significado de la revolución hoy. Esta inadecuación plantea un primer problema, pues el título y el subtítulo suscitan en el lector expectativas que luego no se ven correspondidas por lo que John Holloway trata en sus trescientas páginas. De ahí que el libro haya provocado muchas reacciones negativas, y hasta destempladas, entre marxistas de las diferentes familias.
MARIA TERESA VENTURA RODRÍGUEZ, UNA MIRADA AL SINDICALISMO DE AYER A TRAVÉS DE LA CONSTANCIA MEXICANA, PUEBLA, BENEMÉRITA UNIVERSIDAD AUTÓNOMA DE PUEBLA, INSTITUTO DE CIENCIAS SOCIALES Y HUMANIDADES "ALFONSO VÉLEZ PLIEGO", 2011, 388 PP.
Authors: Rosas Salas Sergio Francisco 
Published: May 2024

El objetivo del libro Una mirada al sindicalismo de ayer... es ofrecer un panorama general del movimiento obrero textil poblano a través del estudio de caso del sindicato de la primera fábrica del ramo establecida en Puebla, pues, como sabemos, fue fundada en 1835 por Estevan de Antuñano. La tesis central de la doctora Ventura es que en La Constancia Mexicana se fraguó una lenta conciencia de clase en la clase obrera poblana, que tomó prácticamente un siglo en madurar y alcanzó su mayor expresión con la fundación del sindicato Mártires de Chicago, al amparo de la protección legal de la Constitución de 1917, cuya historia reconstruye entre 1917 y 1972.
PIKETTY, THOMAS (2014). EL CAPITAL EN EL SIGLO XXI. MÉXICO: FCE. ¿THOMAS PIKETTY, UN ECONOMISTA MAINSTREAM?
Authors: Cortés Gómez José Luis 
Published: May 2024

Es común que en los pasillos de las facultades de economía se cuente el siguiente chiste: la vida académica de un economista está dividida en dos partes, la primera parte trata de explicar cómo su teoría podría solucionar los problemas actuales; la segunda parte explicará el por qué no funcionó su teoría. Tal vez se considere un mal chiste, sin embargo, refleja perfectamente la vida de la mayoría de los economistas. ¿Pero qué tipo de economistas entran en esta reflexión? J. M. Keynes los llamaba economistas mainstream (término para la ortodoxia económica), pero Lord Keynes también condujo su vida académica de este modo.
BASCHET, JERÔME. (2015). ADIÓS AL CAPITALISMO. AUTONOMÍA, SOCIEDAD DEL BUEN VIVIR Y MULTIPLICIDAD DE MUNDOS. ESPAÑA: NED EDICIONES.
Authors: Fini Danielle 
Published: May 2024

Una afirmación ardua es la que aparece en el título de este libro. Así como ardua es la tarea que se propone su autor: pensar la posibilidad de liberarnos del capitalismo. El punto de partida para esta tarea es alejarse de aquellas posturas –definidas “capitulismo” (13)– que se limitan a denunciar los crímenes de este sistema, para terminar inclinándose frente a su aparente invencibilidad o que proponen soluciones dentro del mismo en nombre del realismo.
Assessment Management in Higher Education
Authors: Al-Ali Maytha 
Published: May 2024

This paper presents key findings from a study conducted with several universities in the GCC region regarding their approach and use of e-Assessment within their learning environments. The study identifies key factors that could impact the use and quality of e-Assessment, and describe how those factors could influence forming a consistent and effective approach to employ a long-term e-Assessment approach. Data was collected from several higher education institutions in the GCC region, using an online survey, in-depth interviews with academic administrators, and direct observation. The study identifies six critical factors that may have a direct or indirect impact on forming a consistent and effective approach to employ a long-term e-Assessment approach. Moreover, the study reveals a strong correlation between e-Assessment quality, and the centralization of e-Assessment strategy, e-Assessment administration, and e-Assessment Technology.
Asymmetric aza-Henry reaction toward trifluoromethyl β-nitroamines and biological investigation of their adamantane-type derivatives
Authors: Ren Yi , Du Mengyuan , Peng Ziyu , Zheng Changwu , Zhao Gang 
Published: May 2024

Amino acid-derived quaternary ammonium salts were successfully applied in the asymmetric aza-Henry reaction of nitromethane to N-Boc trifluoromethyl ketimines. α-Trifluoromethyl β-nitroamines were synthesized in good to excellent yields with moderate to good enantioselectivities. This reaction is distinguished by its mild conditions, low catalyst loading (1 mol%), and catalytic base. It also proceeded on a gram scale without loss of enantioselectivity. The products were transformed to a series of adamantane-type compounds containing chiral trifluoromethylamine fragments. The potent anticancer activities of these compounds against liver cancer HepG2 and melanoma B16F10 were evaluated. Six promising compounds with notable efficacy have potential for further development.
Unlocking the antiviral potential of rosmarinic acid against chikungunya virus via IL-17 signaling pathway
Authors: Liao Xinfei , Xin Jialiang , Yu Ziping , Yan Weiming , Li Chenghui , Cao Liang , Zhang He , Wang Wei 
Published: May 2024

BackgroundThe Chikungunya virus is an Alphavirus that belongs to the Togaviridae family and is primarily transmitted by mosquitoes. It causes acute infection characterized by fever, headache, and arthralgia. Some patients also experience persistent chronic osteoarthritis-like symptoms. Dedicated antiviral treatments are currently unavailable for CHIKV. This study aims to explore the potential anti-CHIKV effect of rosmarinic acid using network pharmacology.MethodsThis study employed network pharmacology to predict and verify the molecular targets and pathways associated with ROSA in the context of CHIKV. The analysis outcomes were further validated using molecular docking and in vitro experiments.ResultsThe analysis of CHIKV targets using the Kyoto Encyclopedia of Genes and Genomes and MCODE identified IL-17 as an important pathogenic pathway in CHIKV infection. Among the 30 targets of ROSA against CHIKV, nearly half were found to be involved in the IL-17 signaling pathway. This suggests that ROSA may help the host in resisting CHIKV invasion by modulating this pathway. Molecular docking validation results showed that ROSA can stably bind to 10 core targets out of the 30 identified targets. In an in vitro CHIKV infection model developed using 293T cells, treatment with 60 μM ROSA significantly improved the survival rate of infected cells, inhibited 50% CHIKV proliferation after CHIKV infection, and reduced the expression of TNF-α in the IL-17 signaling pathway.ConclusionThis study provides the first confirmation of the efficacy of ROSA in suppressing CHIKV infection through the IL-17 signaling pathway. The findings warrant further investigation to facilitate the development of ROSA as a potential treatment for CHIKV infection.
Yoga improves self-reported cognitive function among cancer survivors: results from the STAYFit trial
Authors: Gothe Neha P. , Erlenbach Emily , Salerno Elizabeth A. 
Published: May 2024

IntroductionVarious physical activity-based interventions have been tested to determine their efficacy in improving cancer related cognitive decline (CRCD), however the role of mind-body practices such as yoga remains to be explored. In this manuscript we present preliminary effects of yoga vs. aerobic and stretching-toning modalities of exercise on CRCD among adult cancer survivors.MethodsParticipants (N = 78) were randomized to one of the three exercise groups for a duration of 12-weeks and engaged in ≥150 min per week of supervised group exercises. At baseline and following the 12-week interventions, participants completed the Functional Assessment of Cancer Therapy–Cognitive Function.ResultsResults demonstrated a significant group*time interaction for FACT-Cog perceived cognitive abilities subscale, with participants in the yoga group demonstrating a significant increase as compared to the aerobic and stretching-toning groups. The FACT-Cog total score showed a significant time effect with all groups demonstrating a significant increase at follow-up. Other subscales did not show any significant improvements.DiscussionThese findings provide promising evidence for the effects of yoga on self-reported cognitive function in cancer survivors. Notably, 12-weeks of yoga showed an increase in the perceived cognitive abilities and demonstrated a clinically meaningful increase in total cognitive function as measured by the FACT-Cog, suggesting that this exercise modality has the potential to impact this important health outcome during cancer survivorship.Trial registrationClinicalTrials.gov, identifier: NCT03650322.
Impact of COVID-19 on the primary level teaching-learning process in rural India
Authors: Vivek S. , Rangasami P. 
Published: May 2024

PurposeCOVID-19 outbreak impacts people globally. It is not simply a global health matter; it has a terrible influence on the social life of humans, counting the worldwide education structure and other phases of present social configurations. Therefore, the present study's objective is to identify the impact of COVID-19 on the online education approach in teachers' perceptions.MethodologyThe study performs a mixed research approach for evaluating the teachers' perspectives in the online education system. The quantitative data are collected with the support of a questionnaire from 175 respondents (Public School teachers), and in-depth telephonic interviews are conducted among 25 schoolteachers using a semi-structured questionnaire for qualitative data. The quantitative analysis is performed using Statistical Package for Social Sciences (SPSS), and the qualitative analysis is coded and analyzed thematically.FindingsThe quantitative results show that the COVID-19 pandemic negatively impacted the online teaching method; teachers' adaptation here seems low. In contrast, communication with school leaders is provided a clear view of online teaching methods. The key findings from the qualitative analysis show that the adaptation online education system is complex owing to various struggles. Some institutions facilitate training sessions to teach in a range of adopting the online education system. Finally, the teachers need help making students actively participate in online classes.DiscussionThe study conducts original survey through both interview and questionnaire. The results are determined through thematic and data analysis.
Unveiling the molecular complexity of proliferative diabetic retinopathy through scRNA-seq, AlphaFold 2, and machine learning
Authors: Wang Jun , Sun Hongyan , Mou Lisha , Lu Ying , Wu Zijing , Pu Zuhui , Yang Ming-ming 
Published: May 2024

BackgroundProliferative diabetic retinopathy (PDR), a major cause of blindness, is characterized by complex pathogenesis. This study integrates single-cell RNA sequencing (scRNA-seq), Non-negative Matrix Factorization (NMF), machine learning, and AlphaFold 2 methods to explore the molecular level of PDR.MethodsWe analyzed scRNA-seq data from PDR patients and healthy controls to identify distinct cellular subtypes and gene expression patterns. NMF was used to define specific transcriptional programs in PDR. The oxidative stress-related genes (ORGs) identified within Meta-Program 1 were utilized to construct a predictive model using twelve machine learning algorithms. Furthermore, we employed AlphaFold 2 for the prediction of protein structures, complementing this with molecular docking to validate the structural foundation of potential therapeutic targets. We also analyzed protein−protein interaction (PPI) networks and the interplay among key ORGs.ResultsOur scRNA-seq analysis revealed five major cell types and 14 subcell types in PDR patients, with significant differences in gene expression compared to those in controls. We identified three key meta-programs underscoring the role of microglia in the pathogenesis of PDR. Three critical ORGs (ALKBH1, PSIP1, and ATP13A2) were identified, with the best-performing predictive model demonstrating high accuracy (AUC of 0.989 in the training cohort and 0.833 in the validation cohort). Moreover, AlphaFold 2 predictions combined with molecular docking revealed that resveratrol has a strong affinity for ALKBH1, indicating its potential as a targeted therapeutic agent. PPI network analysis, revealed a complex network of interactions among the hub ORGs and other genes, suggesting a collective role in PDR pathogenesis.ConclusionThis study provides insights into the cellular and molecular aspects of PDR, identifying potential biomarkers and therapeutic targets using advanced technological approaches.
Deciphering genetic factors contributing to enhanced resistance against Cercospora leaf blight in soybean (Glycine max L.) using GWAS analysis
Authors: Patel Jinesh , Allen Tom W. , Buckley Blair , Chen Pengyin , Clubb Michael , Mozzoni Leandro A. , Orazaly Moldir , Florez Liliana , Moseley David , Rupe John C. , Shrestha Bishnu K. , Price Paul P. , Ward Brian M. , Koebernick Jenny 
Published: May 2024

Cercospora leaf blight (CLB), caused by Cercospora cf. flagellaris, C. kikuchii, and C. cf. sigesbeckiae, is a significant soybean [Glycine max (L.) Merr.] disease in regions with hot and humid conditions causing yield loss in the United States and Canada. There is limited information regarding resistant soybean cultivars, and there have been marginal efforts to identify the genomic regions underlying resistance to CLB. A Genome-Wide Association Study was conducted using a diverse panel of 460 soybean accessions from maturity groups III to VII to identify the genomic regions associated to the CLB disease. These accessions were evaluated for CLB in different regions of the southeastern United States over 3 years. In total, the study identified 99 Single Nucleotide Polymorphism (SNPs) associated with the disease severity and 85 SNPs associated with disease incidence. Across multiple environments, 47 disease severity SNPs and 23 incidence SNPs were common. Candidate genes within 10 kb of these SNPs were involved in biotic and abiotic stress pathways. This information will contribute to the development of resistant soybean germplasm. Further research is warranted to study the effect of pyramiding desirable genomic regions and investigate the role of identified genes in soybean CLB resistance.