bluuebunny/crossref_metadata_2025_split huggingface dataset:
Senescence rates in patients with end‐stage renal disease: a critical appraisal of the Gompertz model
Authors: Koopman J. J. E. , Rozing M. P. , Kramer A. , de Jager D. J. , Ansell D. , De Meester J. M. J. , Prütz K. G. , Finne P. , Heaf J. G. , Palsson R. , Kramar R. , Jager K. J. , Dekker F. W. , Westendorp R. G. J. 
Published: November 2010

SummaryThe most frequently used model to describe the exponential increase in mortality rate over age is the Gompertz equation. Logarithmically transformed, the equation conforms to a straight line, of which the slope has been interpreted as the rate of senescence. Earlier, we proposed the derivative function of the Gompertz equation as a superior descriptor of senescence rate. Here, we tested both measures of the rate of senescence in a population of patients with end‐stage renal disease. It is clinical dogma that patients on dialysis experience accelerated senescence, whereas those with a functional kidney transplant have mortality rates comparable to the general population. Therefore, we calculated the age‐specific mortality rates for European patients on dialysis (n = 274 221; follow‐up = 594 767 person‐years), for European patients with a functioning kidney transplant (n = 61 286; follow‐up = 345 024 person‐years), and for the general European population. We found higher mortality rates, but a smaller slope of logarithmic mortality curve for patients on dialysis compared with both patients with a functioning kidney transplant and the general population (P < 0.001). A classical interpretation of the Gompertz model would imply that the rate of senescence in patients on dialysis is lower than in patients with a functioning transplant and lower than in the general population. In contrast, the derivative function of the Gompertz equation yielded the highest senescence rates for patients on dialysis, whereas the rate was similar in patients with a functioning transplant and the general population. We conclude that the rate of senescence is better described by the derivative function of the Gompertz equation.
Age‐related trends in female stress urinary incontinence surgery in Australia – Medicare data for 1994–2009
Authors: LEE Joseph , DWYER Peter L. 
Published: November 2010

Background:  Urinary incontinence has a high burden of suffering in Australia. There has been a significant shift towards less invasive surgery for stress urinary incontinence (SUI) over the last 15 years. Elderly women are underrepresented in surgical treatment of SUI.Aims:  To identify patterns in the surgical treatment of women with SUI in Australia from January 1994 to December 2009.Methods:  Gender‐ and age‐specific data from Medicare Australia between January 1994 and December 2009 were extracted. Surgical procedures were identified using Medicare Benefit Schedules codes. Pattern of SUI surgery was analysed during the 15‐year period.Results:  Using data from Medicare Australia, we reported trends in female SUI surgery across Australia from 1994 to 2009. The overall number of female SUI operations has increased, almost doubling over a 3‐year period following the introduction of the midurethral sling (MUS). The per capita rate increase in all SUI surgery is most prominent in women over the age of 55 years increasing 87%, compared with only 1% in younger women over the 15‐year period. MUS have overtaken Burch Colposuspension as the most popular operation for female SUI across all age groups, accounting for 85.5% of all procedures performed in 2009 with 14 MUS for every one colposuspension.Conclusions:  Stress incontinence procedures performed in Australia have almost doubled with the introduction of the MUS with the greatest increase in women aged over 55 years. MUS has overtaken the Burch Colposuspension as the most popular operation for stress urinary incontinence for women in Australia.
Ross syndrome: Unilateral hyperhidrosis, Adie's tonic pupils and diffuse areflexia
Authors: Yaşar Şirin , Aslan Canan , Serdar Zehra Aşiran , Demirci Gülşen Tükenmez , Tutkavul Kemal , Babalik Dilek 
Published: November 2010

SummaryRoss syndrome is a rare disorder first described in 1958 with partial autonomic dysfunction. It has three basic components including unilateral or bilateral segmental anhidrosis, Adie's tonic pupils and areflexia or hyporeflexia of deep tendon reflexes. The most disturbing symptom in the patients is segmental compensatory hyperhidrosis and often the hypohidrosis or anhidrosis is not even noticed. While the pathogenesis of Ross syndrome is unclear, degenerative changes or damage to the peripheral autonomic nerve system or dorsal root ganglia have been suggested as possible causes. About 50 cases have been reported, usually by neurologists and ophthalmologists, and less often by dermatologists. We present a 26‐year‐old patient who displayed the classic triad of this syndrome, emphasizing that the presenting complaint may be hyperhidrosis and that multidisciplinary evaluation in neurology and ophthalmology is essential.
La Fédération de Russie face aux défis du vieillissement et de la sécurité sociale dans un contexte de crise démographique
Authors: Eberstadt Nicholas , Groth Hans 
Published: November 2010

RésuméLe présent article porte sur la crise démographique que traverse la Fédération de Russie et analyse ses conséquences sur la capacité des autorités russes (ou du peuple russe, à travers ses propres efforts) à créer suffisamment de ressources financières pour garantir une sécuritééconomique satisfaisante aux personnes âgées. Dans l’ensemble, la structure démographique de la Russie est similaire à celle d’autres sociétés de régions plus développées. Or, les obstacles auxquels le pays est et sera confronté dans les décennies à venir sont beaucoup plus difficiles à surmonter que ceux auxquels se heurtent la plupart des membres de l’OCDE pour pourvoir aux besoins d’une population qui vieillit. Le problème est notamment compliqué par le fait que les Russes en âge de travailler ont une santé beaucoup plus précaire et une mortalité nettement plus élevée que leurs homologues vivant dans des pays qui ont un niveau de revenu similaire — voire plus faible. Bien que l’analyse présentée ici porte sur les pensions, les raisons pour lesquelles il va être difficile de garantir des pensions adéquates vont entraîner des difficultés tout aussi importantes dans d’autres domaines de la protection sociale. Par conséquent, la réussite de la politique conduite par la Russie en matière de sécurité sociale ne dépend pas exclusivement de la mise en œuvre de programmes sociaux. Elle suppose aussi de réduire les taux de mortalité au sein de la population en âge de travailler, de redynamiser l’enseignement supérieur et de réformer en profondeur les institutions et les politiques économiques du pays.
Bronchoalveolar lavage fluid and progression of scleroderma interstitial lung disease
Authors: De Santis Maria , Bosello Silvia Laura , Peluso Giusy , Pinnelli Michela , Alivernini Stefano , Zizzo Gaetano , Bocci Mario , Capacci Annunziata , La Torre Giuseppe , Mannocci Alice , Pagliari Gabriella , Varone Francesco , Pistelli Roberto , Danza Francesco Maria , Ferraccioli Gianfranco 
Published: November 2010

AbstractIntroduction:  So far no clinical or experimental evidences clearly explain how and which systemic sclerosis (SSc) patients will experience a functional and radiological progression of interstitial lung disease (ILD).Objectives:  The aim of the study was to investigate whether any bronchoalveolar lavage fluid (BALF) characteristic, compared with clinical, functional and radiological parameters, is associated with the risk of progression of ILD and worse survival in SSc patients.Methods:  Lung involvement was evaluated in 110 consecutively examined SSc patients with pulmonary function tests (PFTs) and high‐resolution computed tomography (HRCT); 73 patients with evidence of ILD on HRCT underwent BAL. The progression of ILD was evaluated with PFTs and HRCT after 1‐year follow‐up. A 36‐month survival analysis was assessed.Results:  ILD patients with alveolitis had a higher risk to have restrictive lung disease and honeycombing, to experience a worsening in honeycombing score or to develop honeycombing. ILD progression was associated with the evidence of honeycombing on HRCT, with the presence of eosinophils, with an inverted CD4/CD8 ratio and with a higher CD19 percentage count in the BALF or with a positive BALF microbiological culture. The patients with ILD had a worse overall survival. The diffuse disease was the only independent risk factor of overall mortality, and the extent of honeycombing on HRCT was the only independent risk factor of lung disease‐related mortality.Conclusion:  Our study suggests the importance of evaluating ILD with HRCT and BAL in order to characterize the risk factors of SSc lung involvement progression.Please cite this paper as: De Santis M, Bosello SL, Peluso G, Pinnelli M, Alivernini S, Zizzo G, Bocci M, Capacci A, La Torre G, Mannocci A, Pagliari G, Varone F, Pistelli R, Danza FM and Ferraccioli G. Bronchoalveolar lavage fluid and progression of scleroderma interstitial lung disease. Clin Respir J 2012; 6; 9–17.
Transcriptome sequencing and high‐resolution melt analysis advance single nucleotide polymorphism discovery in duplicated salmonids
Authors: SEEB J. E. , PASCAL C. E. , GRAU E. D. , SEEB L. W. , TEMPLIN W. D. , HARKINS T. , ROBERTS S. B. 
Published: November 2010

AbstractUntil recently, single nucleotide polymorphism (SNP) discovery in nonmodel organisms faced many challenges, often depending upon a targeted‐gene approach and Sanger sequencing of many individuals. The advent of next‐generation sequencing technologies has dramatically improved discovery, but validating and testing SNPs for use in population studies remain labour intensive. Here, we detail a SNP discovery and validation pipeline that incorporates 454 pyrosequencing, high‐resolution melt analysis (HRMA) and 5′ nuclease genotyping. We generated 4.59 × 108 bp of redundant sequence from transcriptomes of two individual chum salmon, a highly valued species across the Pacific Rim. Nearly 26 000 putative SNPs were identified—some as heterozygotes and some as homozygous for different nucleotides in the two individuals. For validation, we selected 202 templates containing single putative SNPs and conducted HRMA on 10 individuals from each of 19 populations from across the species range. Finally, 5′ nuclease genotyping validated 37 SNPs that conformed to Hardy–Weinberg equilibrium expectations. Putative SNPs expressed as heterozygotes in an ascertainment individual had more than twice the validation rate of those homozygous for different alleles in the two fish, suggesting that many of the latter may have been paralogous sequence variants. Overall, this validation rate of 37/202 suggests that we have found more than 4500 templates containing SNPs for use in this population set. We anticipate using this pipeline to significantly expand the number of SNPs available for the studies of population structure and mixture analyses as well as for the studies of adaptive genetic variation in nonmodel organisms.
Making the transition from PK to DSEK: experiences during the learning curve
Authors: Ólafsdóttir Eydís 
Published: November 2010

Abstract.Purpose:  To report our experiences during the transition from penetrating keratoplasty to Descemet’s stripping with endothelial keratoplasty (DSEK).Methods:  All patients undergoing DSEK during the period of April 2008 to April 2009 were included in this study.Results:  All grafts were attached and clear at both the 6‐ and 12 ‐month follow‐up examinations. Mean best‐corrected visual acuity was 0.6 at 6 months and 0.7 at 12 months for patients without other ocular comorbidity.Conclusion:  With adequate attention to detail, DSEK seems to be a safe and successful treatment for corneal endothelial disease, also during the surgeon’s learning curve.
New York's One Judge‐One Family Response to Family Violence
Authors: Aldrich Liberty , Harris Kluger Judge Judy 
Published: November 2010

ABSTRACTThis article reviews the history and implications of New York's one judge‐one family domestic violence courts. These courts were designed to reduce the burden on victims caused by overlapping and occasionally conflicting civil and criminal jurisdictions in domestic violence cases. The article details the obstacles and objections to this unified approach and spells out how those concerns have been addressed in New York. It describes a typical case example in order to show how the ideas work in practice. Finally, the piece argues that, based on what we know so far, a one judge‐one family approach can improve the justice system's ability to provide contextualized and individualized responses to address the complicated reality of many domestic violence cases.
Using fine‐scale GIS data to assess the relationship between intra‐annual environmental niche variability and population density in a local stream fish assemblage
Authors: Knouft Jason H. , Caruso Nicholas M. , Dupre Patrick J. , Anderson Karl R. , Trumbo Daryl R. , Puccinelli Jean 
Published: November 2010

Summary 1. Geographic information systems (GIS) have recently proved useful for estimating the environmental niche of species across broad geographic regions. However, the application of these niche‐based GIS techniques has yet to be extensively applied to local systems. The assumptions of the methods are transferable across scales: species exist across a range of habitats, and these habitats represent a gradient of suitability that can be characterized using multivariate environmental data in association with known species occurrences. 2. Habitat availability and species’ niche characteristics are often considered to be important predictors of population density. However, seasonal habitat variability and stochastic events have been hypothesized to limit interactions among species and confound the relationship between available habitat, species niche characteristics and community structure. This research examines the relationship between environmental niche breadth and niche position and population density among species of stream fishes in a seasonally variable environment using a novel application of fine‐scale GIS data. 3. Niche breadth and niche position were estimated for 11 species in a local assemblage using five fine‐scale (0·5 m) GIS‐based environmental data sets collected during four different times of the year (July, October, January, April). We compared niche measures to variation in population density among species to determine whether environmental niche characteristics, in the context of available habitat, explain variation in numbers of individuals among species. 4. Variation in population density among species in the October sample was predicted by niche breadth measures (R2 = 0·752), while variation in population density among species in the January sample was predicted by a model incorporating measures of both niche breadth and niche position (R2 = 0·953). Measures of niche breadth and niche position were not correlated with variation in population density in the July and April samples. 5. Species presence and local abundance are often assumed to be predictable based on the availability of suitable habitat. However, little effort has been directed at understanding the influence of both niche breadth and niche position on local abundance. Our results suggest that the amount and distribution of available habitat can be a strong predictor of interspecific variation in population density, even in seasonally variable environments.
A randomised trial of medical qigong for cancer patients
Authors: Gundling K 
Published: November 2010

Oh B, Butow P, Mullan B, Clarke S, Beale P, Pavlakis N, Kothe E, Lam L, Rosenthal D. Impact of medical Qigong on quality of life, fatigue, mood and inflammation in cancer patients: a randomized controlled trial. Ann Oncol 2010; 21: 608–14.
Mediastinal Tuberculosis in an Adult Patient with Cystic Fibrosis
Authors: Morand Philippe C. , Burgel Pierre-Régis , Carlotti Agnès , Desmazes-Dufeu Nadine , Farhi David , Martin Clémence , Kanaan Reem , Mangialavori Luigi , Palangié Estelle , Dusser Daniel , Poyart Claire , Hubert Dominique 
Published: November 2010

ABSTRACT
Tuberculosis (TB) is rarely observed in cystic fibrosis (CF) patients. We report the first case of mediastinal TB, associated with leg pain and skin rash, in an adult patient with CF, and discuss factors suggestive of TB in the course of CF.
The I222V Neuraminidase Mutation Has a Compensatory Role in Replication of an Oseltamivir-Resistant Influenza Virus A/H3N2 E119V Mutant
Authors: Simon Philippe , Holder Benjamin P. , Bouhy Xavier , Abed Yacine , Beauchemin Catherine A. A. , Boivin Guy 
Published: November 2010

ABSTRACT
Oseltamivir-resistant A/H3N2 influenza isolates with or without the E119V and I222V neuraminidase (NA) mutations were recovered from an immunocompromised patient. Based on plaque size, yield assays, and NA activity, the impaired viral fitness of the E119V mutant was partially restored by the I222V NA mutation.
The Hypervariable HIV-1 Capsid Protein Residues Comprise HLA-Driven CD8
+
T-Cell Escape Mutations and Covarying HLA-Independent Polymorphisms
Authors: Crawford Hayley , Matthews Philippa C. , Schaefer Malinda , Carlson Jonathan M. , Leslie Alasdair , Kilembe William , Allen Susan , Ndung'u Thumbi , Heckerman David , Hunter Eric , Goulder Philip J. R. 
Published: November 2010

ABSTRACT

One proposed HIV vaccine strategy is to induce Gag-specific CD8
+
T-cell responses that can corner the virus, through fitness cost of viral escape and unavailability of compensatory mutations. We show here that the most variable capsid residues principally comprise escape mutants driven by protective alleles HLA-B*57, -5801, and -8101 and covarying HLA-independent polymorphisms that arise in conjunction with these escape mutations. These covarying polymorphisms are potentially compensatory and are concentrated around three tropism-determining loops of p24, suggesting structural interdependencies. Our results demonstrate complex patterns of adaptation of HIV under immune selection pressure, the understanding of which should aid vaccine design.
Rabbinic Philosophy of Language: Not in Heaven
Authors: Levy Gabriel 
Published: November 2010

AbstractI argue that “sampling” is at the heart of rabbinical hermeneutics. I argue further that anomalous monism—and specifically its arguments about token identity, of which sampling is one species—provides some insight into understanding the nature of rabbinical hermeneutics and religion, where truth is contingent on social judgment but is nevertheless objective. These points are illustrated through a close reading of the story of the oven of Aknai in the Bavli’s Baba Metzia. I claim that rabbinic Judaism represents an early attempt to integrate written texts into communicative processes, and thus frame the essay by comparing it to more recent computational technologies.
Women’s Human, Ecclesial and Missionary Identity: What Insights Does the Pauline Correspondence Offer the Contemporary Woman?
Authors: Smith Susan 
Published: November 2010

AbstractA careful exegesis of the seven letters that the majority of contemporary NT scholars hold that Paul wrote suggests that women had significant public ecclesial and missionary roles in the primitive Christian communities. However, the Deutero-Pauline letters point to a shift in the status of women who appear to have lost the public roles that they formerly held. Over the succeeding centuries, women were increasingly denied public ecclesial and missionary roles. In the Catholic tradition, the ecclesial and missionary vocation came to be understood as flowing from ordination rather than baptism, a development which relegated women to an ancillary role in the Church’s exercise of mission. Vatican II reaffirmed that it is through baptism all the faithful are called to mission. In other words, missionary identity flowed from baptism, not ordination with its gender specific character. This paper proposes to demonstrate the centrality of the Pauline letters for better understanding women’s ecclesial and missionary identities.
Mission and Theological Education ‐ Berlin, Athens, and Tranquebar: A North American Perspective
Authors: Nessan Craig L. 
Published: November 2010

AbstractAn intense discussion of the nature and purpose of theological education has insufficiently regarded the vital importance of the missionary perspective. This article reviews the contemporary debate about theological education with special reference to the contributions of Edward Farley and David Kelsey. The prevailing paradigms of “Berlin” and “Athens” need to be complemented through the perspective of “Tranquebar.” Through a critical appreciation of the work of Bartholomaeus Ziegenbalg (1682‐1719), the retrieval of a fresh and urgently needed missionary paradigm can be facilitated for the contemporary work of theological education. Ziegenbalg demonstrated attentiveness to local culture, collected and cataloged perspectives on South Indian deities, respected the dignity of the Tamil people, and embodied a vibrant theology of mission. The implications of his contribution are translated into an agenda for theological education today and are illustrated through the example of one particular theological school.
Inquiring into Empire: Princeton Seminary’s Society of Inquiry on Missions, the British Empire, and the Opium Trade, Ca. 1830‐1850
Authors: Bruner Jason 
Published: November 2010

AbstractPrinceton Seminary was intimately involved in the North American foreign missions movement in the nineteenth century. One remarkable dimension of this involvement came through the student-led Society of Inquiry on Missions, which sought to gather information about the global state of the Christian mission enterprise. This paper examines the Society’s correspondence with Protestant missionaries in China regarding their attitudes to the British Empire in the years 1830‐1850. It argues that the theological notion of providence informed Princetonians’ perceptions of the world, which consequently dissociated the Christian missionary task with any particular nation or empire. An examination of the Society of Inquiry’s correspondence during the mid-nineteenth century reveals much about Protestant missionaries and their interactions with the opium trade and the results of the First Opium War (1839‐1842). Princetonians’ responses to the opium trade and the First Opium War led ultimately to a significant critique of western commercial influence in East Asia. In conclusion, this paper questions the extent to which commerce, empire, and Christian missions were inherently associated in nineteenth century American Protestant missionary activity.
Baptism in the Zionist Churches of Africa:Traditional African Elements and Christian Sources in a Dialectic Complementarity?
Authors: Austnaberg Hans 
Published: November 2010

AbstractAfrican Initiatives in Christianity (AICs) are the fastest-growing expression of Christianity on the African continent today. In this article, A. F. Walls’ famous “indigenising” and “pilgrim” principles are applied to the practice of baptism in Zionist churches. Its research question asks if the indigenising principle has taken over completely to the loss of the pilgrim principle, or if the two stand in a complementary and dialectical relationship. After presenting G. Oosthuizen’s descriptions of these churches’ rituals of baptism, the author then investigates to what extent baptisms in these churches both take into account the members’ African cultural conditioning and, on the other hand, also work to critique and transform elements in their cultures. How should one evaluate the attempt of the Zionists to contextualise their Christianity with regards to baptism? The article concludes by saying that many elements of their baptisms stand in a complementary and dialectic relationship, embodying both the indigenizing and pilgrim principles.