bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Nexus of Identity, Emotions, and Agency in Virtual Exchanges Between Pre‐Service Teachers From Türkiye and the United States
Authors: Uştuk Özgehan , Yazan Bedrettin , Uzum Baburhan , Akayoglu Sedat , Keleş Ufuk 
Published: February 2025

ABSTRACTThis study draws on data gleaned from multimodal identity tasks in an eight‐week telecollaboration project involving 120 pre‐service teachers from two teacher education programs in Türkiye and the United States. The authors explore what emotions teachers expressed during their participation in telecollaboration and how their emotions intersected with their teacher agency and identity construction. The intersectionality of language teachers’ identities and teachers’ emotions as agency informed the study's conceptual framework. Utilizing multimodal critical discourse analysis, the authors found that pre‐service teachers asserted projective agency by expressing emotions through multimodal and narrative identity tasks. The findings showed that the pre‐service teachers’ identity work was influenced by ecologically contextualized psycho‐emotional circumstances throughout the project. Underscoring that teacher identity work cannot be conceptualized without attending to teachers’ emotions and agency, the authors argue that when intentionally integrated into teacher education courses, identity tasks open experiential dimensions for pre‐service teachers to engage in agentive and emotionally laden identity work. The study contributes to language teacher education research, highlighting the supranational, multicultural, and multilingual nature of the pre‐service teachers' interactions while engaging in online synchronous and asynchronous activities.
Assessing the Health Implications of UV/LED Nail Lamp Radiation Exposure During Manicure and Pedicure Procedures: A Scoping Review
Authors: Beylin Dmitry , Kornhaber Rachel , Le Lagadec Danielle , Cleary Michelle 
Published: February 2025

ABSTRACTSkin malignancies associated with radiation exposure, notably malignant melanoma and keratinocyte carcinoma, are emerging as a significant global health challenge. While indoor tanning beds are associated with skin cancer risk, limited research exists on ultraviolet (UV)/light‐emitting diode (LED) nail lamps used widely in manicures/pedicures. This scoping review aimed to synthesize evidence on the health effects of UV/LED nail lamp exposure during manicures/pedicures. A systematic search of PubMed, Scopus, and CINAHL identified 17 articles, including 12 studies and 5 case reports meeting eligibility criteria published in English from inception to January 2024. Several studies characterized emitted spectra and measured irradiances from commercial lamps, finding predominantly UVA emissions that complied with safety guidelines when correctly used. However, higher exposures exceeding safety limits were also observed. In vitro evidence demonstrated that UV nail lamps potentially induce DNA damage consistent with carcinogenesis. Case reports described squamous cell carcinoma and actinic keratosis restricted to the hands of patients with histories of extensive UV nail lamp exposure. While studies suggested that the cancer risks from typical use are acceptably low, there is room for improvement. Measurements have shown that the doses of UV emission vary across different lamps yet remain low. Surveys have revealed a need for more consumer awareness regarding these risks. Current evidence is insufficient to support the mandatory implementation of protective measures such as gloves or sunscreen during UV nail lamp exposure. More importantly, a direct causal link between UV nail lamps and carcinoma development has not been conclusively established.
Teaching contributions of senior clinicians in a Basic Physician Trainee training programme
Authors: Holdsworth Rhiannon L. , Petropoulos Harry , Spies Michael C. 
Published: February 2025

AbstractEducation of Basic Physician Trainees (BPTs) in preparation for their Royal Australasian College of Physician Divisional Examinations requires time contribution by senior medical staff towards formal teaching activities. This study, conducted at a major metropolitan teaching hospital, sought to quantify the time commitment of senior medical staff towards teaching of BPTs in one clinical year, as well as the perceptions of those staff regarding time commitments through anonymous questionnaire. Senior medical staff involved in formal teaching activities provided a mean of 10 h; questionnaire respondents indicated a mean contribution of 20 h. This study highlights the significant time contribution of senior medical staff to formal teaching activities for BPTs, as well as identifies possible unmeasured teaching contributions.
Waterlogging Does Not Have a Lasting Impact on Yield Performance and Micronutrient Status of Oat (Avena sativa)
Authors: Pitann Britta , Hoppenheit Timo , Mühling Karl H. 
Published: February 2025

ABSTRACTWaterlogging increasingly threatens global crop production, particularly affecting major crops like wheat, barley, and maize at all growth stages. Although research on oat tolerance to waterlogging is limited, there is evidence that oat may be a suitable alternative crop due to its resilience and ability to maintain yields despite nutrient imbalances caused by waterlogging. However, it remains uncertain how oat responds to changes in soil micronutrient availability during periods of waterlogging. Therefore, this study aims to investigate whether (1) micronutrient toxicities or deficiencies are induced during waterlogging, (2) the timing of the flooding event is relevant for the expression of a possible nutrient imbalance, and (3) micronutrient toxicities/deficiencies affect yield performance. In order not to exclude possible varietal differences, three oat varieties were grown in large‐scale containers and exposed to 14 days of waterlogging at either BBCH 31 or BBCH 51. Although early but not late waterlogging was effective in reducing dry weights, especially in white oat, yield performance, as reflected by the harvest index, was not affected at all. While early waterlogging increased Mn and Fe concentrations in all oat varieties, they were well below toxic level. In contrast, Cu concentrations in white oat dropped below the deficiency threshold levels. Zinc status, however, remained completely unaffected in all oat varieties. After late waterlogging, only Mn accumulated to concentration in the toxicity range, but only in white and yellow oat; all other micronutrients remained in a sufficient range From these results we conclude, that although micronutrient imbalances occurred under waterlogging regardless from its timing, which may explain the transient reduction in dry weight of white oat, the yield of all tested oat varieties was ultimately unaffected. It can therefore be assumed that at least the oat varieties tested have a high regeneration potential and also show a high tolerance to transient micronutrient imbalances.
Increased Life Expectancy of People With Profound Intellectual and Multiple Disabilities: What Does It Change for Parents?
Authors: Baumstarck Karine , Del Duca Sibylle , El Ouazzani Houria , Hamouda Ilyes , Beltran Anzola Any , Aim Marie‐Anastasie , Rousseau Marie‐Christine 
Published: February 2025

ABSTRACTBackgroundAdvancements in medicine have increased the life expectancy of the people with profound intellectual and multiple disabilities. The hypothesis is that as parents get older, they worry about no longer being there for their child. This paper explores the extent to which the experiences of older parents may differ from that of younger parents.MethodThe participants were parents of people included in the French EVAL‐PLH cohort. Psychological status, quality of life and coping were compared between (i) parents of the youngest persons (< 20 years) versus parents of the oldest persons (≥ 35 years); (ii) youngest (< 45 years) versus oldest parents (≥ 55 years).ResultsCompared with the youngest parents, the oldest parents did not differ in anxiety–mood disorders, quality of life or coping strategies used.ConclusionWe did not confirm that ageing generates psychological changes for parents. Future qualitative studies should deeply examine this underexplored issue.Trial Registration: Clinical trial number: NCT02400528
Pelagic distribution and night foraging of early juvenile European catfish (Silurus glanisL.)
Authors: Sajdlová Zuzana , Jůza Tomáš , Blabolil Petr , Draštík Vladislav , Čech Martin 
Published: February 2025

AbstractThis study provides evidence of pelagic occurrence and night feeding in early juvenile European catfish that contributed 0.2% to the early juvenile pelagic community at night in Klíčava, 0.3% in Římov, and 3.3% in Žlutice Reservoirs in the Czech Republic. The catfish occurred mostly at a depth of 2–4 m. Their abundance was 5.5 inds.1000 m−3 in Klíčava Reservoir (2018), 0.3 inds.1000 m−3 in Římov Reservoir (2018), and 88.8 inds.1000 m−3 in Žlutice Reservoir (2019). Catfish fed on phantom midges (Chaoborus sp.).
Socio‐Demographic Determinants of Mediterranean Diet Adherence: Results of the EU‐National Health Interview Survey (EHIS‐3)
Authors: Kontele Ioanna , Panagiotakos Demosthenes , Yannakoulia Mary , Vassilakou Tonia 
Published: February 2025

ABSTRACTBackgroundDespite the well‐known benefits of the Mediterranean diet (MD), low adherence is observed globally, highlighting the need to investigate the underlying causes of this trend. Large‐scale, periodically repeated surveys, such as the European Health Interview Survey (EHIS), could be useful for the investigation of the factors that influence adherence to healthy dietary patterns. National EHIS‐3 in Greece was designed to collect data on the consumption of all food groups, making it possible to determine adherence to MD.MethodologyThis study aimed to investigate the socioeconomic factors that influence MD adherence by conducting a secondary data analysis from 7706 participants aged 15–85 years who participated in the 2019 national EHIS. MD adherence was evaluated by MedDietScore. Bivariate comparisons between the score tertiles and socioeconomic groups were performed. Logistic regression analyses were used to estimate the association between MedDietScore tertiles and demographic and socioeconomic factors, using high adherence as the reference category. Finally, cluster analysis was applied to identify the most significant factors in relation to the classification of the participants in MD adherence groups.ResultsEducational level, followed by income status, emerged as the most significant factor associated with adherence to MD. Individuals who have attained only primary education had a 3.80 times higher likelihood of presenting low MD adherence instead of high MD adherence compared to persons with tertiary education. Individuals in the lower income group had 2.53 times higher odds of being in the low MD adherence instead of high MD adherence than individuals in the higher income group. These relationships remained statistically significant after adjusting for confounding factors. The group that most frequently adhered to high MD (53.4%) comprised individuals who had tertiary education, higher income, and were couples without children. Conversely, those with primary or secondary education who are single parents or live in one‐person households and fall into the lower and medium income groups are most likely to have low MD adherence (44.8%).ConclusionsPublic policies to promote MD adherence should consider socioeconomic factors. Integrating questions to evaluate adherence to dietary patterns into EHIS would allow for future intercountry and longitudinal comparisons.
DBB2 regulates plant height and shade avoidance responses in maize
Authors: Wang Xiaofei , Jiao Zihao , Zhang Yonghui , Shi Qingbiao , Wang Qibin , Zhou Fengli , Xu Di , Wang Guodong , Kong Fanying , Zhang Haisen , Li Pinghua , Wang Haiyang , Li Gang 
Published: February 2025

ABSTRACTIncreasing plant density has been recognized as an effective strategy for boosting maize yields over the past few decades. However, dense planting significantly reduces the internal light intensity and the red to far‐red (R:FR) light ratio in the canopy, which subsequently triggers shade avoidance responses (SAR) that limit further yield enhancements, particularly under high‐density conditions. In this study, we identified double B‐box containing protein DBB2, a member of the ZmBBX family that is rapidly induced by shade, as a crucial regulator of plant height and SAR. Disruption of DBB2 resulted in shorter internodes, reduced plant height, decreased cell elongation, and diminished sensitivity to shade in maize, effects that can be largely alleviated by external treatment with gibberellins (GA). Furthermore, we discovered that DBB2 physically interacted with the transcription factor HY5, inhibiting its transcriptional activation of ZmGA2ox4, a gene encoding a GA2 oxidase that can deactivate GA. This interaction positively influences maize plant height through the GA pathway. Additionally, we found that the induction of ZmDBB2 by shade is mediated by the transcription factor PIF4. Interestingly, DBB2 then interacted with PIF4 to enhance the transcriptional activation of cell elongation‐related genes, such as ZmEXPA1, thereby establishing a positive feedback loop promoting cell elongation under canopy shade conditions. Our findings highlight the critical role of BBX proteins in modulating plant height and SAR, presenting them as key genetic targets for developing maize varieties suited to high‐density planting conditions. This study also provides new insights into the molecular mechanisms underlying SAR and offers potential strategies for the genetic improvement of maize plant architecture and grain yield.
SMALL AND ROUND GRAIN is involved in the brassinosteroid signaling pathway which regulates grain size in rice
Authors: Miao Rong , Lin Qibing , Cao Penghui , Zhou Chunlei , Feng Miao , Lan Jie , Luo Sheng , Zhang Fulin , Wu Hongmin , Hao Qixian , Zheng Hai , Ma Tengfei , Huang Yunshuai , Mou Changling , Nguyen Thanhliem , Cheng Zhijun , Guo Xiuping , Liu Shijia , Jiang Ling , Wan Jianmin 
Published: February 2025

ABSTRACTGrain size is a key determinant of 1,000‐grain weight, one of three factors determining grain yield. However, the complete regulatory network controlling grain size has not been fully clarified. Here, we identified a rice mutant, named small and round grain (srg) that exhibits semi‐dwarf stature and small grain size. Cytological analysis showed that cell length and number of spikelet epidermal cells of the srg mutant are reduced, indicating that SRG controls grain size by promoting cell elongation and increasing cell number. SRG encodes a kinesin belonging to the kinesin‐1 subfamily and is extensively expressed in different plant tissues with relatively high expression in young panicles. SRG protein is mainly located in the nucleus and cell membrane. Expression of the SRG gene was induced by brassinolide through the brassinosteroid (BR) responsive factor OsWRKY53 and SRG protein was phosphorylated by BR‐activated kinase OsBSK3 to prevent its degradation. In addition, microtubule (MT) morphology was abnormal and disordered in the srg and cr‐1 mutants. These findings suggest that BR likely stabilizes orderly assembly and arrangement of MTs by stabilizing SRG proteins, thus promoting grain size. SRG overexpression lines produced more tillers and significantly larger and heavier grains to increase 1,000‐grain weight, suggesting that SRG has potential to increase grain yield. Our study indicated that SRG is a new BR responsive factor and BR might regulate grain size by influencing the expression of SRG.
Hunger Games: A Modern Battle Between Stress and Appetite
Authors: Smith Whitnei , Azevedo Estefania P. 
Published: February 2025

ABSTRACTStress, an evolutionarily adaptive mechanism, has become a pervasive challenge in modern life, significantly impacting feeding‐relevant circuits that play a role in the development and pathogenesis of eating disorders (EDs). Stress activates the hypothalamic–pituitary–adrenal (HPA) axis, disrupts specific neural circuits, and dysregulates key brain regions, including the hypothalamus, hippocampus, and lateral septum. These particular structures are interconnected and key in integrating stress and feeding signals, modulating hunger, satiety, cognition, and emotional coping behaviors. Here we discuss the interplay between genetic predispositions and environmental factors that may exacerbate ED vulnerability. We also highlight the most commonly used animal models to study the mechanisms driving EDs and recent rodent studies that emphasize the discovery of novel cellular and molecular mechanisms integrating stress and feeding signals within the hippocampus–lateral septum–hypothalamus axis. In this review, we discuss the role of gut microbiome, an emerging area of research in the field of EDs and unanswered questions that persist and hinder the scientific progress, such as why some individuals remain resilient to stress while others become at high risk for the development of EDs. We finally discuss the need for future research delineating the impact of specific stressors on neural circuits, clarifying the relevance and functionality of hippocampal–septal–hypothalamic connectivity, and investigating the role of key neuropeptides such as CRH, oxytocin, and GLP‐1 in human ED pathogenesis. Emerging tools like single‐cell sequencing and advanced human imaging could uncover cellular and circuit‐level changes in brain areas relevant for feeding in ED patients. Ultimately, by integrating basic and clinical research, science offers promising avenues for developing personalized, mechanism‐based treatments targeting maladaptive eating behavior for patients suffering from EDs.image
Oxidative Stress Suppresses Trk Signaling While Stimulating JNK‐Mediated Endocytosis and Cleavage of p75NTR: A Targetable Pathway for Neuroprotection in a Parkinson's Disease Model
Authors: Pokharel Poshan V. , Newchurch Aaron M. , Overby Sunny C. , Spease Cassidy A. , Perkins Isaac T. , Darzi Lorelei G. , Ghimire Nabin , Lawan Ahmed , Kraemer Bradley R. 
Published: February 2025

ABSTRACTThe p75 Neurotrophin Receptor (p75NTR) is a multifunctional transmembrane protein that mediates neuronal responses to pathological conditions in specific regions of the nervous system. In many biological contexts, p75NTR signaling is initiated through sequential cleavage of the receptor by α‐ and γ‐secretases, which releases receptor fragments for downstream signaling. Our previous research demonstrated that proteolytic processing of p75NTR in this manner is stimulated by oxidative stress in Lund Human Mesencephalic (LUHMES) cells, a dopaminergic neuronal cell line derived from human mesencephalic tissue. Considering the vulnerability of dopaminergic neurons in the ventral mesencephalon to oxidative stress and neurodegeneration associated with Parkinson's disease (PD), we investigated the role of this signaling cascade in neurodegeneration and explored cellular processes that govern oxidative stress‐induced p75NTR signaling. In the present study, we provide evidence that oxidative stress induces cleavage of p75NTR by promoting c‐Jun N‐terminal Kinase (JNK)‐dependent internalization of p75NTR from the cell surface. This activation of p75NTR signaling is counteracted by tropomyosin‐related kinase (Trk) receptor signaling; however, oxidative stress leads to Trk receptor downregulation, thereby enhancing p75NTR processing. Importantly, we demonstrate that this pathway can be inhibited by LM11a‐31, a small molecule modulator of p75NTR, thereby conferring protection against neurodegeneration. Treatment with LM11a‐31 significantly reduced p75NTR cleavage and neuronal death associated with oxidative stress. These findings reveal novel mechanisms underlying activation of p75NTR in response to oxidative stress, underscore a key role for p75NTR in dopaminergic neurodegeneration, and highlight p75NTR as a potential therapeutic target for reducing neurodegeneration in PD.image
Nasal Reshaping Using Barbed Threads Combined With Hyaluronic Acid Filler and Botulinum Toxin A
Authors: Ziade G. , Saade R. , Daou D. , Karam D. , Bendito A. , Tsintsadze M. 
Published: February 2025

ABSTRACTBackgroundRhinoplasty is a prominent procedure in facial aesthetics, but extended surgical downtime remains its significant limitation. Nonsurgical rhinoplasty has gained popularity as an alternative, offering significant aesthetic improvements with minimal downtime. This study evaluates the clinical efficacy and safety of three nonsurgical rhinoplasty techniques combined, including hyaluronic acid (HA) filler, botulinum toxin type A (BTX), and barbed lifting threads.MethodsA total of 85 patients were included into three groups: 63 subjects received HA filler and BTX injections, 9 subjects received barbed threads followed by BTX injections, and 13 received threads followed by HA filler and BTX injections. Patients assessed their satisfaction 1 month and a year posttreatment as well as adverse effects 48 h and 1 week after treatment using FACE‐Q questionnaire for nose.ResultsBoth 1 month and a year after treatment, the triple combination of barbed threads with HA filler and BTX demonstrated superior nose FACE‐Q scores compared to the two other groups, showing highest patient satisfaction and minimal efficacy decay over time. No significant difference in FACE‐Q scores was observed between the two groups receiving HA filler + BTX and barbed threads + BTX at either 1 month or a year posttreatment. Adverse effects were reported by subjects in all three groups 48 h posttreatment and completely resolved by 1 week after treatment.ConclusionCombining nonsurgical rhinoplasty techniques—such as lifting threads, HA fillers, and botulinum toxin—can deliver effective aesthetic improvements with minimal downtime. Among these, the triple combination of HA filler, BTX, and lifting threads results in the highest and most sustained patient satisfaction, lasting no less than 1 year.
Longitudinal Identification of Pre‐Lesional Tissue in Multiple Sclerosis With Advanced Diffusion MRI
Authors: Caranova Maria , Soares Júlia F. , Pereira Daniela Jardim , Lima Ana Cláudia , Sousa Lívia , Batista Sónia , Castelo‐Branco Miguel , Duarte João V. 
Published: February 2025

ABSTRACTBackground and PurposeStructural MRI (sMRI) is used in monitoring multiple sclerosis (MS) but lacks sensitivity in detecting clinically relevant damage to normal‐appearing white matter (NAWM), that is, pre‐lesional tissue, and specificity for identifying the underlying substrate of injury. In this longitudinal study, we identified pre‐lesional tissue in MS patients and investigated its microstructure by modeling diffusion‐weighted imaging (DWI) data using diffusion tensor imaging and neurite orientation dispersion and density imaging (NODDI).MethodsWe enrolled 18 patients with relapsing‐remitting MS (10 females, 31.92 ± 8.09 years, disease duration 0.91 ± 1.81 years) and 18 healthy controls (10 females, 31.89 ± 8.15 years). Participants underwent two sMRI and DWI sessions (baseline and follow‐up) with the same protocols. Average apparent diffusion coefficient (ADC), fractional anisotropy (FA), orientation dispersion index (ODI), and neurite density index (NDI) were estimated in data‐driven regions of interest: nonpersistent lesional tissue (lesional tissue at baseline, resolved at follow‐up), lesions that only existed at follow‐up (pre‐lesional tissue at baseline, lesions at follow‐up), persistent lesional tissue (lesions at baseline and follow‐up), and NAWM.ResultsCompared to NAWM, pre‐lesional tissue showed lower ODI, and resolved lesional tissue showed higher FA and ADC and lower ODI and NDI. Over time, persistent lesional tissue showed a decrease in FA and ODI and an increase in NDI. Compared to nonpersistent lesional tissue, persistent lesional tissue showed higher ADC and lower NDI.ConclusionsDWI and, more particularly, NODDI, can reveal the unique microstructure of persistent, resolved, and pre‐lesional tissue in MS.