bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of psychological functioning in the use of complementary and alternative methods among disease‐free colorectal cancer survivors
Authors: Stein Kevin D. , Kaw Chiewkwei , Crammer Corinne , Gansler Ted 
Published: July 2010

AbstractBACKGROUND:The medical and demographic correlates of complementary and alternative medicine (CAM) use among cancer survivors have been well documented. However, the role of psychological functioning in cancer survivors' CAM use and the degree to which such factors apply to survivors of colorectal cancer require additional study. In addition, sex differences in CAM use and its correlates among colorectal cancer survivors are not well understood.METHODS:By using data from a large‐scale national population‐based study of quality of life and health behaviors among cancer survivors, the authors examined the prevalence and psychological correlates of CAM use among 252 male and 277 female colorectal cancer survivors.RESULTS:Use of CAM was more common among women, those with more education, and recipients of chemotherapy and radiation therapy. Several psychological factors predicted increased use of CAM among female colorectal cancer survivors, including anxiety, fear of cancer recurrence, fatigue, vigor, anger, mental confusion, and overall emotional distress. Depression was associated with decreased CAM use among female survivors, both for overall CAM use and across several standard CAM domains. In contrast, psychological functioning had little impact on male colorectal cancer survivors' CAM use. The only nonmedical/demographic variable associated with men's use of CAM was fatigue, which predicted use only of biologically based practices, such as diet and nutritional supplements.CONCLUSIONS:Psychological functioning has a significant impact on CAM use among female colorectal cancer survivors. Decreased use of CAM among women with depressive symptoms was unexpected and warrants additional investigation. Cancer 2009;115(18 suppl):4397–408. © 2009 American Cancer Society.
A mobile spectrophotometer for art conservation
Authors: Wright W. D. 
Published: July 2010

AbstractThis article describes a nonrecording spectrophotometer designed for use as a tool in the restoration and conservation of paintings. A small patch of monochromatic light of any desired wavelength is projected onto the precise area of the painting to be measured and the light reflected from the painting is compared with that reflected from a calibrated working standard. The measuring head of the instrument and a specially designed easel are both provided with alignment controls to bring the monochromatic patch onto the required point of the painting. The instrument itself is mounted on a trolley so that it can be wheeled into position facing the easel. The uses to which the instrument will be put include the measurement of colour changes due to the cleaning, revarmshing, and relining of a painting, and environmental conditions; the identification of the pigments used by the artist; spectral reflectance measurements to assist the conservator with in‐painting a damaged or “lost” area; and tests on new artists' materials including the effect of drying and aging.
The aim and method of the color image scale
Authors: Kobayashi Shigenobu 
Published: July 2010

AbstractA Color Image Scale was devised by the use of an original color‐projection technique, analysis of variance, cluster analysis, factor analysis, and the semantic differential method. On this scale every color has three attributes: warm or cool, soft or hard, and clear or grayish, which correlate with the notation hue, value, and chroma. The Color Image Scale is useful for describing the similar and contrasting images of colors. The scale also allows the classification and correlation of various objects (shapes, patterns, clothing, foods, etc.) and the study of personal preferences in these and other areas.
Divorce mediation outcome research: A meta‐analysis
Authors: Shaw Lori Anne 
Published: July 2010

AbstractResults vary across divorce mediation and litigation outcome studies. Because a quantitative review has never been performed on this body of research, the present study conducts a meta‐analysis on this literature. From five studies that met the established inclusion criteria, it was found that mediation produced a grand effect size of 0.36. This small‐to‐moderate effect size reveals that across the included studies mediation is a beneficial alternative to litigation for divorcing couples. Dependent variables measuring process satisfaction, outcome satisfaction, emotional satisfaction, spousal relationship, and understanding children's needs were aggregated across the studies, rendering moderate positive effect size.
An Acetate‐Functionalized Tetranuclear Zirconium Sandwiching Polyoxometalate Complex
Authors: Zhang Wei , Liu Shu‐Xia , Zhang Chun‐Dan , Tan Rui‐Kang , Ma Feng‐Ji , Li Shu‐Jun , Zhang Yuan‐Yuan 
Published: July 2010

AbstractThe dimeric, zirconium‐sandwiching compound K4H6[Zr4(OH)6(CH3COO)2(α‐PW10O37)2]·23H2O (1) was obtained by the reaction of lacunary [PW11O39]7– and ZrCl4 in a 1 M potassium acetate buffer. It was characterized by elemental and thermogravimetric analysis, X‐ray crystallography, solution 183W NMR, FTIR, and UV spectroscopy, and cyclic voltammetry (CV). All the studies indicate that compound 1 is stable both in the solid state and in solution. The cyclic voltammograms indicate good electrocatalytic activity in the reduction of nitrite.
Comparison of serum versus plasma collection in gas chromatography – Mass spectrometry‐based metabolomics
Authors: Dettmer Katja , Almstetter Martin F. , Appel Inka J. , Nürnberger Nadine , Schlamberger Gregor , Gronwald Wolfram , Meyer Heinrich H. D. , Oefner Peter J. 
Published: July 2010

AbstractBovine serum, EDTA‐plasma and EDTA‐plasma fortified with acetylsalicylic acid (ASA) as antioxidant were compared with regard to their suitability for metabolomic studies. Metabolic fingerprints were generated from GC‐TOF‐MS data using the Leco ChromaTOF® software in combination with the in‐house retention time correction and data alignment tool INCA. A total of 6, 9 and 21 significant features with a false discovery rate of <0.05 were identified by INCA upon comparing EDTA‐ versus EDTA‐ASA‐plasma, EDTA‐plasma versus serum and EDTA‐ASA‐plasma versus serum, respectively. To confirm that the observed signal intensities in the GC‐TOF‐MS fingerprints reflected true metabolite abundances, 19 amino acids, glucose and 6 organic acids were quantified by means of GC‐MS using stable‐isotope‐labeled internal standards. As observed with the fingerprints, only the concentrations of lactate and citrate were found to be significantly lower in EDTA‐plasma and serum, respectively, whereas the concentrations of the other metabolites were similar among the three sample types investigated.
Multi‐exon genotyping of SMN gene in spinal muscular atrophy by universal fluorescent PCR and capillary electrophoresis
Authors: Wang Chun‐Chi , Chang Jan‐Gowth , Chen Yen‐Ling , Jong Yuh‐Jyh , Wu Shou‐Mei 
Published: July 2010

AbstractIn this study, we established the first method for simultaneous evaluation of nine exons in the survival motor neuron (SMN) genes for full‐scale genotyping. This method was used not only to quantify the copy numbers of highly homogenous telomeric SMN (SMN1)/centromeric SMN genes in exons 7 and 8 but also to determine intragenic mutations in all nine exons for complete diagnosis of spinal muscular atrophy (SMA). Additionally, we utilized the “universal fluorescent PCR” for simultaneously fluorescent labeling of eleven gene fragments (nine exons in SMN and two internal standards). Such technique is very beneficial for multi‐exon analysis due to only requirement of one universal fluorescent primer which could fluorescently amplify all gene fragments. Of all 262 detected individuals, three subjects possessing different ratios of SMN1/centromeric SMN in the two exons were determined as gene conversion, and we also detected three interesting intragenic mutations (c.1 ‐39A>G, c.22_23insA in exon 1, c.84C>T in exon 2a) which were associated with the SMA patients owning one copy of SMN1 including two mutations never reported previously. This high‐resolved method provided better potential technique for genotyping and identifying SMA, carrier and normal controls in large population.
Modification of heavy metal uptake efficiency by modified chitosan/anionic surfactant systems
Authors: Negm Nabel A. , Ali Hanan Elsharkawy 
Published: July 2010

AbstractThe presence of toxic heavy metals in natural environments entails a potential health hazard for humans. Metal contaminants in these environments are usually tightly bound to colloidal particles and organic matter. On the other hand, the potential of these metals towards chelation by different chelating agents presents a good characteristic for their removal from the environment. On this basis, two chitosan/anionic surfactant complexes were prepared and evaluated for their ability to remove heavy metals from aqueous solutions. The experimental results of the uptake of metal ions including Cu2+, Sn2+, Co2+ and Ni2+ are reported in this study. The results show that modified chitosan with short‐spacer group cross‐linkers has a higher potential for heavy metal uptake than long‐chain cross‐linker‐modified chitosan. Also, increasing the electronegativity of the heavy metals increases their uptake from the medium. Increasing the time of exposure of the heavy metals to the modified polymer increases the efficiency of the metal uptake process.
Influence of temperature on growth of Scenedesmus obliquus in diluted olive mill wastewater as culture medium
Authors: Hodaifa Gassan , Martínez Ma Eugenia , Sánchez Sebastián 
Published: July 2010

AbstractScenedesmus obliquus can help to reduce the environmental impact of industrial olive mill wastewater from olive oil extraction in the three‐phase system. This work examines the effect of temperature changes (288–308 K) on algal growth, culture medium, and biochemical composition of S. obliquus. The maximum specific growth rate of 0.024 h−1 occurred at an optimal temperature of 302.7 K. The apparent activation energies of cell growth and cell death were determined as 61.8 and 142.8 kJ/mol, respectively. At the end of culture the percentages of pigments, proteins, and carbohydrates were greater at the two ends of the temperature range studied, as it was also observed for the maximum elimination of biochemical oxygen demand (BOD5). The mono‐ and polyunsaturated fatty acid content of the biomass was greater at the lowest temperature used (288 K).
Incidence of salivary gland cancer in the United States relative to ultraviolet radiation exposure
Authors: Spitz Margaret R. , Sider Joanne G. , Newell Guy R. , Batsakis John G. 
Published: July 2010

AbstractThere is biologic and histogenetic plausibility for an association between salivary gland cancer and nonmelanoma skin cancer. To add further credence to this association, a descriptive epidemiologic study of salivary gland cancer incidence data from the Surveillance Epidemiology and End Results (SEER) program from 1973 to 1981 was undertaken. The objective was to determine whether the incidence of this cancer exhibited the inverse association with geographic latitude that is characteristic of skin cancer incidence. The SEER areas were grouped into three regions (north, central, and south), based on indices of ultraviolet radiation. The southern area had significantly higher rates for white males and females compared with the northern area for all histologic subtypes combined (standardized incidence ratios were 1.6 for males and 1.4 for females), as well as for specific histologic subtypes (adenocarcinoma, squamous cell carcinoma, and males only with mucoepidermoid carcinoma). However, there were no significant differences in incidence between the central and northern areas. These data provide further evidence of an association between skin and salivary neoplasms, both exhibiting a pattern of incidence suggestive of susceptibility to ultraviolet radiation exposure.
Mixed odontogenic tumors: An analysis of 23 new cases
Authors: Hansen Louis S. , Ficarra Giuseppe 
Published: July 2010

AbstractThe ameloblastic fibroma, ameloblastic fibrodentinoma, and ameloblastic fibro‐odontoma are mixed odontogenic tumors that are considered to arise from both epithelial and mesenchymal elements of the tooth germ. This article presents the clinical and histopathologic characteristics of 23 new cases. The patients' ages ranged from 3 to 19 years (median 9). Most tumors were asymptomatic and were associated with an unerupted tooth or teeth. All patients were treated with simple enucleation of the tumor. We found that histologically these lesions comprise a spectrum. Some were probably benign odontogenic tumors (neoplasms) and others were odontomas undergoing maturation (hamartomas); however, in any given case we were, on histologic grounds, unable to differentiate the two. The majority, if not all, of our cases were nonaggressive with little or no tendency to recur, whereas some reported cases have exhibited local aggressiveness and recurrence, suggestive of neoplasia. In our opinion, it is clinically important to distinguish the mixed odontogenic tumors from ameloblastoma since the mixed tumors, found mostly in children, are relatively benign when compared to ameloblastoma, which is found in all age groups (usually adults). The usually innocuous behavior of these lesions does not justify aggressive treatment initially, and simple enucleation should be appropriate in most cases.
Hurthle cell adenoma of the thyroglossal duct
Authors: Tovi Ferit , Fliss Dan M. , Inbar‐Yanai Nana 
Published: July 2010

AbstractNeoplasia in thyroglossal duct cysts or ectopic thyroid tissue deposits is rare but well recognized. The first known case of Hurthle cell adenoma in thyroglossal duct anomaly is described. The pathologic course and treatment of Hurthle cell tumors in general is reviewed. Treatment was based on the view that neoplasms in thyroglossal duct remnants represent changes in the ectopic thyroid tissue.
Loss of Repression of HuR Translation by miR‐16 May Be Responsible for the Elevation of HuR in Human Breast Carcinoma
Authors: Xu Fang , Zhang Xiaotian , Lei Yutao , Liu Xinwen , Liu Zhenyun , Tong Tanjun , Wang Wengong 
Published: July 2010

AbstractElevated levels of RNA binding protein HuR were found in various human cancers. However, the mechanisms underlying HuR over‐expression in cancers have not been fully elucidated. Here, we show that miR‐16 acts as a novel post‐transcriptional regulator for HuR. Knockdown of miR‐16 increased HuR protein levels in MDA‐MB‐231 cells, while over‐expression of pre‐miR16 reduced HuR expression. Neither knockdown nor over‐expression of miR‐16 could alter the mRNA levels of HuR. Instead, knockdown of miR‐16 increased the level of de novo synthesized HuR protein. Importantly, mechanistic studies showed that miR‐16 associated with the 3′UTR of HuR, and knockdown of miR‐16 markedly increased the luciferase activity of a HuR 3′UTR‐containing reporter. We further demonstrate that the level of miR‐16 was inversely correlated with HuR protein level in human breast carcinoma. Together, our results suggest an important role of miR‐16 in regulating HuR translation and link this regulatory pathway to human breast cancer. J. Cell. Biochem. 111: 727–734, 2010. © 2010 Wiley‐Liss, Inc.
Reactive oxygen species are involved in the IFN‐γ‐stimulated production of Th2 chemokines in HaCaT keratinocytes
Authors: Qi Xu‐Feng , Teng Yung‐Chien , Yoon Yang‐Suk , Kim Dong‐Heui , Cai Dong‐Qing , Lee Kyu‐Jae 
Published: July 2010

AbstractThe increased generation of reactive oxygen species (ROS) induces inflammation in different cell types. However, it is unclear whether ROS play an essential role in the production of thymus and activation‐regulated chemokine (TARC/CCL17) and macrophage‐derived chemokine (MDC/CCL22) in keratinocytes. Here, we investigated the function of ROS in the production of these two Th2 chemokines in interferon‐gamma (IFN‐γ)‐treated HaCaT keratinocytes. We found that IFN‐γ‐induced production of both chemokines in parallel with the increased generation of intracellular ROS. A ROS scavenger, N‐acetyl cysteine (NAC), significantly inhibited the IFN‐γ‐induced production of chemokines as well as the activation of I kappa‐B (IκB)–nuclear factor‐kappa B (NF‐κB). Inhibitors of Janus family kinases (JAKs), p38 mitogen‐activated kinase (MAPK), and NF‐κB suppressed IFN‐γ‐induced production of TARC and MDC. NF‐κB activation was inhibited by both inhibitors of JAKs and p38 MAPK. Importantly, IFN‐γ‐stimulated phosphorylation of p38 MAPK was significantly suppressed by JAKs inhibitors, but not significantly affected by NAC or L‐buthionine sulfoximine (L‐BSO). However, IFN‐γ‐stimulated activation of IκB and NF‐κB was suppressed by NAC but enhanced by BSO. Furthermore, inhibition of p38 MAPK and JAKs did not affect ROS generation in IFN‐γ‐stimulated HaCaT cells. These results indicate that intracellular ROS and JAKs/p38 MAPK both contribute independently to IFN‐γ‐stimulated production of TARC and MDC in HaCaT keratinocytes, by increasing NF‐κB activation. J. Cell. Physiol. 226: 58–65, 2010. © 2010 Wiley‐Liss, Inc.
Chromatin accessibility and transcription factor binding at the PPARγ2 promoter during adipogenesis is protein kinase A‐dependent
Authors: Xiao Hengyi , LeBlanc Scott E. , Wu Qiong , Konda Silvana , Salma Nunciada , Marfella Concetta G.A. , Ohkawa Yasuyuki , Imbalzano Anthony N. 
Published: July 2010

AbstractThe nuclear hormone receptor peroxisome proliferator‐activated receptor gamma (PPARγ) is a ligand‐activated transcription factor that specifies formation of the adipocyte lineage. PPARγ also serves as a primary target for the treatment of type 2 diabetes, illustrating both its medical relevance as well as the need to understand fundamental aspects of PPARγ expression and function. Here, we characterize molecular changes that occur at the PPARγ2 promoter within the first several hours of adipocyte differentiation in culture. Our results demonstrate that changes in chromatin accessibility at the PPARγ2 promoter and occupancy of the promoter by the c‐Fos transcription factor occur within an hour of the onset of differentiation, followed closely by the binding of the CCAAT/enhancer binding protein beta (C/EBPβ) transcription factor. All three events show a remarkable dependency on protein kinase A (PKA) activity. These results reflect novel requirements for the PKA signaling pathway and reinforce the importance of PKA function during the onset of adipocyte differentiation. J. Cell. Physiol. 226: 86–93, 2010. © 2010 Wiley‐Liss, Inc.
Peritoneal dialysate effluent during peritonitis induces human cardiomyocyte apoptosis by regulating the expression of GATA‐4 and Bcl‐2 families
Authors: Wang Hsin‐Hui , Li Ping‐Chun , Huang Hsiao‐Ju , Lee Tzong‐Yann , Lin Ching‐Yuang 
Published: July 2010

AbstractCardiovascular event and infection are leading causes of death from peritoneal dialysis (PD). This study examined in vitro cellular mechanism for cardiotoxicity induced by PD‐related peritonitis. Cultured human cardiomyocytes were treated with PD effluent (PDE) during peritonitis (PPDE), and effects of PPDE on cultured cardiomyocytes in terms of apoptosis, with expression its related genes assessed. Results showed PPDE treatment of cardiomyocyte leading to onset of apoptosis, as confirmed by phosphatidylserine exposure plus DNA fragmentation and damage. This apoptosis is mediated by reduced Bcl‐2/Bax and Bcl‐xL/Bax ratios, as well as reduced expression of GATA‐4, an important cardiomyocyte survival factor, at the level of transcription. These changes activated pro‐apoptotic pathways. PPDE treatment also inhibited ERK signals, contributing to cardiotoxicity. Our findings revealed that PPDE contains potent pro‐apoptotic factors that regulate expression of GATA‐4 and Bcl‐2 families, inducing cultured cardiomyocyte apoptosis. This pinpoints a key role of apoptosis in PD‐associated cardiovascular events, along with a potential therapeutic target. J. Cell. Physiol. 226: 94–102, 2010. © 2010 Wiley‐Liss, Inc.
TRPM4 enhances cell proliferation through up‐regulation of the β‐catenin signaling pathway
Authors: Armisén Ricardo , Marcelain Katherine , Simon Felipe , Tapia Julio C. , Toro Jessica , Quest Andrew F.G. , Stutzin Andrés 
Published: July 2010

AbstractAltered expression of some members of the TRP ion channel superfamily has been associated with the development of pathologies like cancer. In particular, TRPM4 levels are reportedly elevated in diffuse large B‐cell non‐Hodgkin lymphoma, prostate, and cervical cancer. However, whether such changes in TRPM4 expression may be relevant to genesis or progression of cancer remains unknown. Here we show that reducing TRPM4 expression decreases proliferation of HeLa cells, a cervical cancer‐derived cell line. In this cell line, constitutive TRPM4 silencing promoted GSK‐3β‐dependent degradation of β‐catenin and reduced β‐catenin/Tcf/Lef‐dependent transcription. Conversely, overexpression of TRPM4 in T‐REx 293 cells (a HEK293‐derived cell line) increased cell proliferation and β‐catenin levels. Our results identify TRPM4 as an important, unanticipated regulator of the β‐catenin pathway, where aberrant signaling is frequently associated with cancer. J. Cell. Physiol. 226: 103–109, 2010. © 2010 Wiley‐Liss, Inc.
Adipose tissue‐derived progenitors for engineering osteogenic and vasculogenic grafts
Authors: Scherberich Arnaud , Müller Andreas M. , Schäfer Dirk J. , Banfi Andrea , Martin Ivan 
Published: July 2010

AbstractThe current need for bone grafts in orthopedic and reconstructive surgery cannot be satisfied by autologous tissue transplant due to its limited availability and significant associated morbidity. Tissue engineering approaches could supply sufficient amounts of bone substitutes by exploiting the ability to harvest autologous osteogenic progenitors associated with suitable porous materials. However, the generation of clinically relevant‐sized constructs is critically hampered by limited vascularization, with consequent engraftment and survival only of a thin outer shell, upon in vivo implantation. To overcome this limitation, different non‐mutually exclusive approaches have recently been developed to promote or accelerate graft vascularization, from angiogenic growth factor gene delivery to surgical pre‐vascularization of the construct before implantation. A simple, promising strategy involves the co‐culture of vasculogenic cells to form an intrinsic vascular network inside the graft in vitro, which can rapidly anastomose with the host blood vessels in vivo. Recent data have shown that adipose tissue‐derived stromal vascular fraction (SVF) may provide an efficient, convenient, and autologous source for both osteogenic and endothelial cells. When SVF progenitors were cultured in appropriate bioreactor systems and ectopically implanted, a functional vascular network connected to the host was formed concomitantly to bone formation. Future studies should aim at demonstrating that this approach effectively supports survival of scaled up cell‐based bone grafts at an orthotopic site. The procedure should also be adapted to become compatible with an intra‐operative timeline and complemented with the definition of suitable potency markers, to facilitate its development into a simplified, reproducible, and cost‐effective clinical treatment. J. Cell. Physiol. 225: 348–353, 2010. © 2010 Wiley‐Liss, Inc.