bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Inspiratory Muscle Training on Exercise Capacity, Dyspnea and Cardiac Autonomic Function in Individuals with Chronic Obstructive Pulmonary Disease: A Study Protocol
Authors: Sharma Shikha , Mitra Shambhovi , Sethi Prabhpreet 
Published: May 2024

Abstract

Background: Literature is heterogeneous regarding the benefits of inspiratory muscle training as a part of pulmonary rehabilitation (PR) as a treatment strategy for individuals with chronic obstructive pulmonary disease (COPD). Thus, the study aims to find the combined effect of inspiratory muscle training and PR on dyspnea, exercise capacity, and cardiac autonomic function. The proposed 8-week rehabilitation program shall contribute to the changes in the exercise capacity, dyspnea, and cardiac autonomic function shall also be studied.
Objectives: The primary objective of the study is to assess the changes in exercise capacity after eight weeks of pulmonary rehabilitation (PR). Secondary objectives include changes in dyspnea and cardiac autonomic function in individuals with COPD.
Methods: This study will recruit 36 participants based on the pre-defined inclusion criteria. The participants will be randomly allocated to one of the two groups: the experimental (group A), and the control (group B). The intervention protocol will be delivered for 30–45 minutes per session, three sessions a week for eight weeks.
Results: The outcomes will be measured after 8 weeks of intervention. The exercise capacity, dyspnea, and cardiac autonomic function will be measured using a six-minute walk distance (6MWD), the baseline and transition dyspnea index scale (BDI & TDI), and heart rate variability (HRV) respectively.
Conclusion: This study aims to investigate the efficacy of inspiratory muscle training (IMT) along with peripheral muscle training in improving exercise capacity, dyspnea, and cardiac autonomic function in individuals with COPD. It study will provide evidence of changes in physiological markers that should be addressed for an early prognosis and management of individuals with COPD. Additionally, it can serve as a basis for future studies and reviews to provide knowledge of the study findings.
Trial registration: Clinical Trial Registration- India (CTRI/2023/08/056978).
Views and experiences of people practicing open defecation: Evidence from riverside inhabitants of an Indonesian village
Authors: Utami Ima Hidayati , Dida Susanne , Hadisiwi Purwanti , Prasetyo Bambang Dwi 
Published: May 2024

ABSTRACT
A study conducted in 20 districts of East Java Province revealed that open defecation in communities near water bodies was difficult to intervene in due to a lack of motivation to change. Using a constructivist perspective, this study investigated the views and experiences of individuals with open defecation habits in a riverside village to uncover the underlying reasons for their habits. To gather data, 15 riverside inhabitants who have been defecating in the river since childhood were interviewed, and field observations were conducted. The data were analysed using the Miles & Huberman model for the thematic analysis. The findings revealed that open defecation behaviour among riverside inhabitants was difficult to intervene in because it was associated with (1) social communication experiences; (2) socio-cultural factors; (3) individual attitudes; (4) economic constraints and household size; and (5) the physical environment. This study recommends tailoring sanitation promotion to community conditions and needs, involving community and religious leaders, and encouraging policymakers to protect rivers from industrial activity to improve behaviour change.
Innovative polygon trend analysis for the monthly rainfall in the Mae Klong River Basin, Thailand
Authors: Khalil Alamgir 
Published: May 2024

ABSTRACT
Historical fluctuations in hydroclimatic variables can reveal important information about water resource changes in any basin. The innovative polygon trend analysis (IPTA) method was used to analyze 45-year rainfall data from eight monitoring stations in the Mae Klong River Basin, Thailand. The IPTA graphics were developed for the mean monthly rainfall and the standard deviation of the monthly rainfall for each station. In addition, the IPTA results were compared with the Mann–Kendall (MK) test and the Sen's slope method. The IPTA graphics showed no regular polygon for any rainfall station, which indicated variability of rainfall over the years. The IPTA method showed increasing trends for the month of April while decreasing trends in the month of October for the majority of the stations (7 of 8). A good agreement for detection of trends was found between the IPTA method and the MK test. Both the methods found trends (increasing/decreasing) for 69 months (72%) and showed no trend for 27 months (28%) out of a total of 96 months. The findings of this study could benefit water supply and management, drought monitoring, and agricultural production activities in the Mae Klong River Basin in the future.
A Survey of the Relationship Between Dietary Quality and Metabolic Syndrome
Authors: Mohtashami Alireza 
Published: May 2024

Background:
Dietary intake is increasingly recognized as a pivotal factor in the etiology
of metabolic syndrome. A substantial body of evidence suggests a discernible correlation between
dietary quality indices and the occurrence of metabolic syndrome.

Objective:
This survey seeks to rigorously evaluate the impact of diet quality indices and demographic
variables on the manifestation of metabolic syndrome.

Materials and Methods:
This case-control study encompassed 175 individuals diagnosed with
metabolic syndrome and an equal number of age-matched healthy counterparts (Comprising both
genderS) aged between 20 and 65 years. Participants were sourced from diverse laboratories and
the general population in Chalous, northern Iran. Dietary intake data were meticulously acquired
using a comprehensive Food Frequency Questionnaire (FFQ). Furthermore, dietary quality indices,
specifically the Healthy Eating Index (HEI), Dietary Diversity Score (DDS), Nutrient Adequacy
Ratio (NAR), and Mean Adequacy Ratio (MAR), were meticulously evaluated employing
standardized methodologies.

Results:
There was no significant diversity in the likelihood of developing metabolic syndrome
concerning the Healthy Eating Index (HEI), Nutrient Adequacy Ratio (NAR), and Mean Adequacy
Ratio (MAR) when comparing quartile 4 (Maximum scorE) to quartile 1 (Minimum scorE).
However, this likelihood diminished following adjustments for confounding variables, including
age, sex, dietary energy, education, job, and marital status. In the case of the Dietary Diversity
Score (DDS), there was an observed difference in morbidity likelihood between quartile 4 and
quartile 1. Nevertheless, after meticulous adjustment for confounding variables, this difference
failed to reach statistical significance. No substantial variations (P ≥ 0.05) were detected in the
odds ratio across quartiles and models (P trenD) for all dietary quality indices.

Conclusion:
No significant associations were identified between dietary quality indices and the occurrence
of metabolic syndrome.
Prediction of Age-Related MicroRNA Signature in Mesenchymal Stem
Cells by using Computational Methods
Authors: Salehi Mohammad , Darroudi Majid , Musavi Maryam , Momtazi-Borojeni Amir Abbas 
Published: May 2024

Background:
Aging is a phenomenon which occurs over time and leads to the decay of
living organisms. During the progression of aging, some age-associated diseases including cardiovascular
disease, cancers, and neurological, mental, and physical disorders could develop. Genetic
and epigenetic factors like microRNAs, as one of the post-transcriptional regulators of genes, play
important roles in senescence. The self-renewal and differentiation capacity of mesenchymal stem
cells makes them good candidates for regenerative medicine.

Objective:
The objective of this study is to evaluate senescence-related miRNAs in human MSCs
using bioinformatics analysis.

Methods:
In this study, the Gene Expression Omnibus (GEO) database was used to investigate
the senescence-related genome profile. Then, down-regulated genes were selected for further
bioinformatics analysis with the assumption that their decreased expression is associated with an
increased aging process. Considering that miRNAs can interfere in gene expression, miRNAs
complementary to these genes were identified using bioinformatics software.

Results:
Through bioinformatics analysis, we predicted hsa-miR-590-3p, hsa-miR-10b-3p, hsamiR-
548 family, hsa-miR-144-3p, and hsa-miR-30b-5p which involve in cellular senescence and
the aging of human MSCs.

Conclusion:
miRNA mimics or anti-miRNA agents have the potential to be used as anti-aging
tools for MSCs.
Obesity and Depression: Common Link and Possible Targets
Authors: Jitte Srikanth , Keluth Saritha , Bisht Priya , Wal Pranay , Singh Sanjiv , Murti Krishna , Kumar Nitesh 
Published: May 2024

:
Depression is among the main causes of disability, and its protracted manifestations
could make it even harder to treat metabolic diseases. Obesity is linked to episodes of depression,
which is closely correlated to abdominal adiposity and impaired food quality. The present review is
aimed at studying possible links between obesity and depression along with targets to disrupt it. Research
output in Pubmed and Scopus were referred for writing this manuscript. Obesity and depression
are related, with the greater propensity of depressed people to gain weight, resulting in poor dietary
decisions and a sedentary lifestyle. Adipokines, which include adiponectin, resistin, and leptin
are secretory products of the adipose tissue. These adipokines are now being studied to learn more
about the connection underlying obesity and depression. Ghrelin, a gut hormone, controls both obesity
and depression. Additionally, elevated ghrelin levels result in anxiolytic and antidepressant-like
effects. The gut microbiota influences the metabolic functionalities of a person, like caloric processing
from indigestible nutritional compounds and storage in fatty tissue, that exposes an individual
to obesity, and gut microorganisms might connect to the CNS through interconnecting pathways,
including neurological, endocrine, and immunological signalling systems. The alteration of brain
activity caused by gut bacteria has been related to depressive episodes. Monoamines, including dopamine,
serotonin, and norepinephrine, have been widely believed to have a function in emotions
and appetite control. Emotional signals stimulate arcuate neurons in the hypothalamus that are directly
implicated in mood regulation and eating. The peptide hormone GLP-1(glucagon-like peptide-
1) seems to have a beneficial role as a medical regulator of defective neuroinflammation, neurogenesis,
synaptic dysfunction, and neurotransmitter secretion discrepancy in the depressive brain.
The gut microbiota might have its action in mood and cognition regulation, in addition to its traditional
involvement in GI function regulation. This review addressed the concept that obesity-related
low-grade mild inflammation in the brain contributes to chronic depression and cognitive impairments.
Pandemic Fatigue and Preferences for COVID-19 Public Health and Social Measures in China: Nationwide Discrete Choice Experiment
Authors: Yang Meng , He Zonglin , Zhang Yin , Liu Taoran , Ming Wai-kit 
Published: May 2024

Background
Information on the public’s preferences for current public health and social measures (PHSMs) and people’s mental health under PHSMs is insufficient.

Objective
This study aimed to quantify the public’s preferences for varied PHSMs and measure the level of pandemic fatigue in the COVID-19 normalization stage in China.

Methods
A nationwide cross-sectional study with a discrete choice experiment and psychometric scales was conducted to assess public preferences for and attitudes toward PHSMs, using the quota sampling method. The COVID-19 Pandemic Fatigue Scale (CPFS) was used to screen fatigue levels among respondents. The multinomial logit model, latent class model, and Mann-Whitney test were used for statistical analysis. We also conducted subgroup analysis based on sex, age, monthly income, mental health status, and pandemic fatigue status.

Results
A total of 689 respondents across China completed the survey. The discrete choice experiment revealed that respondents attached the greatest importance to the risk of COVID-19 infection within 3 months (45.53%), followed by loss of income within 3 months (30.69%). Vulnerable populations (low-income populations and elderly people) were more sensitive to the risk of infection, while younger respondents were more sensitive to income loss and preferred nonsuspension of social places and transportation. Migrants and those with pandemic fatigue had less acceptance of the mandatory booster vaccination and suspension of transportation. Additionally, a higher pandemic fatigue level was observed in female respondents, younger respondents, migrants, and relatively lower-income respondents (CPFS correlation with age: r=–0.274, P<.001; correlation with monthly income: r=–0.25, P<.001). Mandatory booster COVID-19 vaccination was also not preferred by respondents with a higher level of pandemic fatigue, while universal COVID-19 booster vaccination was preferred by respondents with a lower level of pandemic fatigue.

Conclusions
Pandemic fatigue is widely prevalent in respondents across China, and respondents desired the resumption of normal social life while being confronted with the fear of COVID-19 infection in the normalization stage of COVID-19 in China. During future pandemics, the mental burden and adherence of residents should be considered for the proper implementation of PHSMs.
Efficacy and Safety of Remimazolam Versus Etomidate for Induction of General Anesthesia: Protocol for a Systematic Review and Meta-Analysis
Authors: Zhao Li , Guo Yiping , Zhou Xuelei , Mao Wei , Chen Linlin , Xie Ying , Li Linji 
Published: May 2024

Background
Postinduction hypotension (PIHO) is a hemodynamic abnormality commonly observed during the induction of general anesthesia. Etomidate is considered a safer drug for the induction of anesthesia because it has only minor adverse effects on the cardiovascular and pulmonary systems. Recent evidence indicates that the novel benzodiazepine remimazolam has minimal inhibitory effects on the circulation and respiration. However, the efficacy and safety of remimazolam versus etomidate in the induction of anesthesia are unclear.

Objective
To further understand the potential of remimazolam in anesthesia induction, it is necessary to design a meta-analysis to compare its effects versus the classic safe anesthetic etomidate. The aim of this study is to determine which drug has more stable hemodynamics and a lower incidence of PIHO. Our study will also yield data on sedation efficiency, time to loss of consciousness, time to awakening, incidence of injection pain, and postoperative nausea and vomiting with the two drugs.

Methods
We plan to search the Web of Science, Cochrane Library, Embase, PubMed, China National Knowledge Infrastructure, and Wanfang databases from the date of their creation until March 31, 2025. The language is limited to English and Chinese. The search terms are “randomized controlled trials,” “etomidate,” and “remimazolam.” The incidence of PIHO is the primary outcome measure. Secondary outcomes include depth of anesthesia after induction, sedation success rate, time to loss of consciousness, hemodynamic profiles, recovery time, incidence of injection pain, and postoperative nausea and vomiting. Reviews, meta-analyses, case studies, abstracts from conferences, and commentaries will not be included. The heterogeneity of the results will be evaluated by sensitivity and subgroup analyses. RevMan software and Stata software will be used for data analysis. We will evaluate the quality of included studies using version 2 of the Cochrane risk-of-bias tool. The confidence of the evidence will be assessed through the Grading of Recommendations, Assessments, Developments, and Evaluations system.

Results
The protocol was registered in the international PROSPERO (Prospective Register of Systematic Reviews) registry in November 2023. As of June 2024, we have performed a preliminary article search and retrieval for further review. The review and analyses are expected to be completed in March 2025. We expect to submit manuscripts for peer review by the end of June 2025.

Conclusions
By synthesizing the available evidence and comparing remimazolam and etomidate, we hope to provide valuable insights into the selection of anesthesia-inducing drugs to reduce the incidence of PIHO and improve patient prognosis.

Trial Registration
PROSPERO CRD42023463120; https://tinyurl.com/333jb8bm

International Registered Report Identifier (IRRID)
PRR1-10.2196/55948
SYNCHRONOUS OBSERVATIONS OF THE MIKHNEVO GEOPHYSICAL OBESRVATORY COORDINATES DISPLACEMENT ACCORDING TO GPS STATION DATA AND VARIATIONS IN THE KINEMATIC AND DYNAMIC PARAMETERS OF SEISMIC WAVES
Authors: Гаврилов Б. Г. , Санина И. А. , Константиновская Н. Л. , Овчинникова О. В. 
Published: May 2024

В работе представлены результаты временных изменений координат измерительного пункта по данным GPS станции и вариаций кинематических и динамических параметров сейсмических волн, полученных на уникальной научной установке Среднеширотный комплекс геофизических наблюдений «Михнево» ИДГ РАН. Показано, что наблюдается подобие в поведении этих параметров в период 2016-2022 гг. Установлена четко выраженная годичная периодичность изменения координат станции и динамических параметров - вариаций логарифма отношения максимальных амплитуд поперечных и продольных волн Lg(ASmax/APmax).
The paper presents the results of temporary changes in the coordinates of the measuring point according to GPS station data and variations in the kinematic and dynamic parameters of seismic waves obtained at the unique scientific installation Mid-latitude complex of geophysical observations «Mikhnevo». It is shown that there is a similarity in the behavior of these parameters in the period 2016-2022. A clearly defined annual periodicity of changes in station coordinates and dynamic parameters has been established variations in the logarithm of the ratio of the maximum amplitudes of transverse and longitudinal waves Lg(ASmax/APmax).
MONITORING THERMODYNAMIC REGIME OF ATMOSPHERIC TURBULENCE
Authors: Рыбнов С. Ю. , Крашенинников А. В. , Соловьев С. П. , Рыбнов Ю. С. 
Published: May 2024

С целью определения влияния крупных городских агломераций на среду обитания при ИДГ РАН с 2014 г. функционирует Центр геофизического мониторинга г. Москвы, в котором систематически выполняются инструментальные наблюдения за геофизическими полями и метеорологическими характеристиками приземной атмосферы. С учетом возникновения новых задач, а также необходимости расширения технических возможностей Центра в 2022 г. проведена его модернизация: расширен перечень регистрирующих средств и обновлены методики наблюдений и анализа данных. Получаемые в Центре данные позволяют оценить взаимосвязь энергетических параметров приземного слоя атмосферы с возмущениями геофизических полей природного итехногенного происхождений и уровнем загрязнения атмосферы мелкодисперсными частицами.
In order to determine the impact of large urban agglomerations on the habitat, the Moscow Geophysical Monitoring Center has been operating at the IDG RAS since 2014, where instrumental observations of geophysical fields and meteorological characteristics of the surface atmosphere are systematically carried out. Taking into account the emergence of new tasks, as well as the need to expand the technical capabilities of the Center in 2022, its modernization was carried out: the list of recording tools was expanded and the methods of observation and data analysis were updated. The data obtained at the Center allow us to assess the relationship between the energy parameters of the surface layer of the atmosphere with disturbances of geophysical fields of natural and man-made origin and the level of atmospheric pollution by fine particles.
MONITORING OF THE INFRASOUND BACKGROUND LEVEL IN GUBKIN, BELGOROD REGION
Authors: Рыбнов Ю. С. , Соловьев С. П. , Крашенинников А. В. , Рыбнов С. Ю. 
Published: May 2024

Описаны инструментальные наблюдения за уровнем инфразвукового фона в полосе частот 1-20 Гц от работающей техники при вывозе руды из карьеров Лебединского и Стойленского ГОКов. Ежедневно в карьерах работают более 130 единиц основной горной техники, которые являются источником интенсивных инфразвуковых колебаний. Измерения проводились в период с июня по октябрь 2022 и 2023 гг. Проведенные исследования показали, что увеличение количества массовых взрывов в 2023 г. и, как следствие, интенсификация вывоза руды, привело к возрастанию инфразвукового фона на 4-9 дБ по сравнению с 2022 г. Однако его значение не превышает предельно допустимые уровни для территории жилой застройки 75÷90 дБ.
Instrumental observations of the level of the infrasound background in the frequency band of 1-20 Hz from working equipment during the export of ore from the Lebedinsky and Stoilensky quarries are described. More than 130 units of basic mining equipment operate in the quarries every day, which are a source of intense infrasound vibrations. The measurements were carried out between June and October 2022 and 2023. The conducted studies have shown that an increase in the number of mass explosions in 2023 and, as a result, the intensification of ore export, led to an increase in the infrasound background by 4-9 dB compared to 2022. However, its value does not exceed the maximum permissible levels for residential areas of 75-90 dB.
И. С. Бах — А. Г. Шнитке: цитата как форма диалога в музыке анимационного кино
Authors: Х. Мэгуми 
Published: May 2024

Статья посвящена одному из важнейших аспектов творческой деятельноти Альфреда Гарриевича Шнитке — его рецепции музыки Иоганна Себастьяна Баха. Проблема исследуется на основе наименее изученной области в наследии Шнитке — его сочинений к анимационным фильмам Андрея Хржановского (р. 1939). Аргументируется точка зрения, что в данной сфере складывались основные формы цитирования и подходы, характерные для претворения композитором определяющих компонентов стиля лейпцигского мастера. В публикации рассмотрены примеры точной, переработанной и виртуальной цитат в киномузыке Шнитке. Подчеркивается, что художественный диалог с творчеством Баха и эпохой барокко сложился у него во многом под влиянием кинематографических идей Хржановского. Исследование основано на изучении автографов партитур, хранящихся в нотной библиотеке Российского государственного симфонического оркестра кинематографии, архивных материалов, воспоминаний композитора и режиссера о создании кинолент, а также интервью, данного Хржановским в личных встречах с автором статьи в январе 2023 г.
The article is devoted to one of the most important aspects of Alfred Schnittke’s creative activity — his reception of music by Johann Sebastian Bach. The author explores this problem on the basis of the least studied field in Schnittke’s legacy — his works for animated films by Andrey Khrzhanovsky (b. 1939). It is argued that main ideas of quoting Bach’s works and principal methods of using his stylistic devices have been formed in this sphere. The publication discusses examples of exact, revised and virtual quotations in the film music by Schnittke. It is emphasized that Schnittke’s artistic dialogue with the oeuvre and epoch of the great German composer was formed under the significant influence of Khrzhanovsky’s cinematographic ideas. The research is based on the study of the composer’s handwritten scores kept in the music library of the Russian State Symphony Cinema Orchestra, archival materials, composer’s and director’s memoires about the films production, as well as interviews given by Khrzhanovsky in personal meetings with the author of the article in January 2023.