bluuebunny/crossref_metadata_2025_split huggingface dataset:
ASSOCIATION OF RS6817105 POLYMORPHISM OF THE PITX2 GENE WITH ATRIAL FIBRILLATION IN PATIENTS WITH ARTERIAL HYPERTENSION IN THE UZBEK POPULATION
Authors: Radjabova Guliruh , Abdullaeva Guzal , Zakirova Dasha , Pulatova Muazzam , Sherbadalova Nigora , Mashkurova Zarina , Abdullayev Alisher 
Published: May 2024

Objective:
Determine the influence of the rs6817105 polymorphism of the PITX2 gene on the risk of developing atrial fibrillation (AF) in patients with arterial hypertension (AH) in the Uzbek population.

Design and method:
Included 142 patients who were initially diagnosed with paroxysmal (n=15), persistent (n=43) and permanent (n=84) forms of AF. Control group (n=88) hypertensive patients without AF. Echocardiography evaluate the indexed left atrial volume (LAVI). Genotyping of samples for carriage of allelic variants rs6817105 by polymorphism of the PITX2 gene was carried out using the RFLP-PCR method. Relative risk (OR) was calculated using genetic models.

Results:
Patients with hypertension and AF,the following distribution of genotypes of rs6817105 polymorphism of the PITX2 gene was revealed: CC genotype -72(50.7%) patients, CT genotype-in 60 (42.3%), TT genotype-10(7.0%), χ2=68.535,p=0.000. The allelic distribution showed a predominance of carriage of the C allele:C allele–71.8%, T allele–28.2%, χ2=106.542, p=0.000. Patients with AH without AF,the C allele also prevailed:59.7% and 40.3%, respectively, χ2=12.375,p=0.000. Ratio of CC:ST:TT genotypes:38.6%:42.1%:19.3%, χ2=12.375, p=0.000. Multiplicative model of inheritance,a significant accumulation of the C allele was demonstrated among 142 patients AH with AF in 71.8% (χ2=7.30;p= 0.007;OR=1.72,95%CI 1.16-2.56),while the T allele was less common in 28.2% cases.General model demonstrated the association of the CC genotype with the risk of developing AF in patients with hypertension,CC genotype was more common in 50.7% (χ2=8.69;P=0.01;OR=1.63,95%CI 0.95-2.81), while CT genotype was found in 42.3% of cases and TT genotype in 7.0%.Group of patients without AF there was a different distribution of CC:CT:TT genotypes:38.6%:42.0%:19.3%,respectively.It is important to note that in hypertensive patients with AF-carriers of the CC genotype rs6817105 polymorphism of the PITX2 gene,the LAVI indicator was significantly higher in comparison with carriers of the CT and TT genotypes:46.8±14.9 ml/m2 versus 40.4±13.0 ml /m2 and 36.5±11.6 ml/m2, respectively(p=0.020).

Conclusions:
CC genotype and the C allele of the rs6817105 polymorphism of the PITX2 gene with the risk of developing AF in patients with hypertension in the Uzbek population. It was noted that in carriers of the CC genotype rs6817105 polymorphism of the PITX2 gene, the LAVI indicator was significantly higher in comparison with carriers of the CT and TT genotypes.
PREVALENCE AND ASSOCIATED PROGNOSIS OF ELECTROCARDIOGRAPHIC FINDINGS IN HYPERTENSIVE PATIENTS. AN ANALYSIS OF A 5-YEAR FOLLOW-UP STUDY
Authors: Stathoulopoulou Maria , Kasiakogias Alexandros , Tsoumpou Ioanna , Siafi Eirini , Tatakis Fotis , Konstantinidis Dimitrios , Leontsinis Ioannis , Fragoulis Christos , Fillipou Christina , Kakouri Niki , Karaminas Nikos , Drogkaris Sotiris , Polyzos Dimitrios , Iliakis Panagiotis , Liatakis Ioannis , Tsioufis Konstantinos 
Published: May 2024

Objective:
Various electrocardiographic abnormalities may be identified in hypertensive patients, but their prognostic significance has not been sufficiently studied. We investigated the presence of diverse ECG findings in a hypertensive population and their predictive ability for cardiovascular disease.

Design and method:
We studied 1851 white Caucasian hypertensive patients (age 58±12years, 51% females) free of cardiovascular disease for a mean period of 5.3±3.4 years. At baseline, all patients underwent standard 12-lead electrocardiography. Left ventricular hypertrophy (LVH) criteria were assessed using both the Sokolow and the Cornel-Voltage formulas. An interventricular conduction delay (IVCD) was defined as a QRS >110msec in the absence of a bundle branch block (BBB). QRS fragmentation was identified as notches in the QRS complex not related to BBB. The QTc interval was considered prolonged if > 440ms in men and >460ms in women. ST depression was defined as >1 mm in depth. The outcome studied was the incidence of cardiovascular morbidity set as the composite of non-fatal coronary artery disease and stroke.

Results:
LVH criteria were fulfilled in 7% with the Sokolow formula and in 5.3% with Cornell Voltage criteria. A prolonged PR was evident in 6.3%. An IVCD, a left BBB and a right BBB were observed in 9%, 4.1% and 1% of the population respectively. QRS fragmentation was identified in 18% of the study population. An early transition zone was found in 30% of the population and a late transition zone in 19%. QTc was prolonged in 9.8% of cases. Prevalence of TWI was 3.8%, of which 39% was anterior TWI, 73% was lateral TWI and 11% was inferior TWI. Incidence of the composite endpoint during follow-up was 4%. Cox regression analysis revealed that only prolonged QTc (HR: 1.86, 95% CI: 0.97-3.54, p=0.06) and presence of TWI (HR: 2.6, 95% CI: 1.1-5.9, p=0.025) were associated with the composite endpoint. In multivariate models controlling for standard confounders the association with TWI was overall sustained.

Conclusions:
Among hypertensive patients without cardiovascular disease, ECG abnormalities are frequent. A prolonged QTc and T wave inversion seem to exhibit prognostic significance for cardiovascular events.
CHANGES IN THE THICKNESS OF THE WALLS OF THE LEFT AND RIGHT VENTRICLES DEPENDING ON THE CAUSE OF DEATH IN PATIENTS WITH ARTERIAL HYPERTENSION ACCORDING TO AUTOPSY STUDY
Authors: Kerimkulova Aiman , Veber Viktor , Markabayeva Akbayan , Nurpeissova Riza , Ospanova Ainur , Adiyeva Madina 
Published: May 2024

Objective:
To explore the relationship between changes in the thickness of the walls of the left and right ventricles according to causes of death among people with arterial hypertension according to autopsy data.

Design and method:
A retrospective study was conducted based on autopsy reports over a period of 16 years. 643 data from autopsy reports were selected for analysis of patients who suffered from arterial hypertension during their lifetime and died suddenly. They did not have any other concomitant diseases leading to cardiac remodeling. The normal wall thickness of the left ventricle was taken as 0.7-1.2 cm, the right ventricle 0.2-0.3 cm.

Results:
The mean age (Me, IQR; 25th to 75th centiles) was 56 (49-63) years, for men - 54 (48-61, n=372); in women - 59 (50-69, n=255, p<0.001) for 643 autopsy reports submitted from patients with hypertension. The main causes of death among patients with arterial hypertension were acute heart failure, myocardial infarction, acute cerebrovascular accident, which was 98.9% (n=636), and they were taken into account in subsequent calculations when comparing groups. Thus, the groups were divided by cause of death: cardiac and cerebral. In the group, there were 62.5% (n=402) cases of cardiac death and 37.5% (n=241) of cerebral death, age was 58 (50-67) and 52 (46-61), respectively, p<0.001. The thickness of the ventricular wall was determined was determined for cardiac and cerebral causes of death, respectively, for the left ventricle 2.5 (2.0-2.5) and for 1.8 (1.6-2.0) cm and for the right ventricle 0.9 (0.6-1.2) and 0.4 (0.3-0.6) cm. The cardiac death case prevailed over the cerebral one with a more pronounced degree of left ventricular hypertrophy (Chi-square 125.2, df=1, p <0.001), and in the presence of right ventricular hypertrophy 25.6 times higher (95% CI 11.6-52.4), the differences in the group were statistically significant (Chi-square 124.2, df=1, p <0.001).

Conclusions:
The main cause of death in people with hypertension was the development of heart failure and myocardial infarction. Cardiac causes of death predominated among individuals with more pronounced changes in the left ventricle and in the presence of hypertrophy of the right ventricle.
REGIONAL CARDIAC PROTEOME ALTERATIONS IN A HYPERTENSION-INDUCED RAT MODEL FOR CHRONIC HEART FAILURE
Authors: Kedziora Sarah Michelle , Popp Oliver , Fahjen Pauline , Kräker Kristin , Mertins Philipp , Müller Dominik Nicolas , Haase Nadine 
Published: May 2024

Objective:
Development of chronic heart failure is promoted by hypertension-induced ventricular stiffening and remodelling. Cardiovascular morbidity and mortality result from a constant rising prevalence in heart failure worldwide. A valuable measure to diagnose heart failure with preserved ejection fraction is speckle-tracking echocardiography to assess cardiac strain. Functional differences in specific cardiac regions can be investigated here. The role of the proteome in these regions remains elusive. Here we hypothesize a distinct proteome signature in intracardiac regions that could explain cardiac functional alterations in different regions of the failing heart.

Design and method:
Double-transgenic rats, expressing the human renin and angiotensinogen (dTGRs) were included in the study at the age of four weeks. Sprague Dawley wild-type (WT) rats served as controls. Echocardiography and speckle tracking echocardiography were used to evaluate cardiac function. In a label-free mass spectrometry approach, the proteome was analysed from six left-ventricular, intracardiac regions: posterior and anterior/septal base, mid and apex.

Results:
Vehicle-treated dTGR presented hypertrophy with an increased echocardiographically measured wall thickness of left-ventricular posterior wall in systole and diastole. Speckle tracking echocardiography indicated a diminished global longitudinal strain in vehicle-treated dTGR compared to WT rats. This indicates a reduction of myocardial movement along the longitudinal dimension. Strain analysis in distinct cardiac regions revealed that the myocardial performance of the posterior apex was most affected, followed by posterior base and mid, as well as anterior/septal apex and base. The anterior/septal mid was not significantly different between the groups. Label-free proteomics approach identified 661 and 789 proteins to be significantly different between posterior apex compared to anterior mid or anterior base, respectively. These differences were diminished in the dTGR heart. All six intracardiac regions displayed an altered protein profile in hearts from dTGR compared to WT, with alterations in proteins such as atrial natriuretic peptide, Serpin B3, Xin-Actin-Binding-Repeat-Containing 1 and pyruvate-dehydrogenase-kinase 4.

Conclusions:
Investigating the shift in cardiac proteome profile can improve our understanding of chronic heart failure and identify potential target proteins. Within this study, we highlight the relevance of intracardiac regions in proteome analysis with respect to chronic heart failure.
CHARACTERISTICS OF A SAMPLE OF ELDERLY HYPERTENSIVE INDIVIDUALS WITH INCREASED RELATIVE WALL THICKNESS (RWT) ON ECHOCARDIOGRAPHY
Authors: Camafort Miguel , Suárez Ana , Benítez Cristina , Fernández Carolina , Aldea Anna , Coloma Emmanuel , Torres Manuel , Mayor Miriam , Viñas Esther , Guio Ana , Sepulveda Constanza , Coca Antonio 
Published: May 2024

Objective:
Arterial hypertension (HTN) is a prevalent disease with relevant morbidity and mortality due to the hypertension mediated organ damages (HMOD). Myocardial HMOD is very frequent. We describe the characteristics of a sample of patients with hypertension who underwent echocardiograms, showing a relative parietal thickness >0.42.

Design and method:
Retrospective review of older patients from the Hypertension clinic of a tertiary hospital during 2019 who underwent an echocardiogram. Anthropometric and analytical variables, vital signs and complementary tests performed on patients with a relative parietal thickness (GPR) value greater than 0.42 were collected.

Results:
From 50 patients included 36 patients had an increased RWT (17 men and 19 women). Mean age was 67 years (± 11.83) with a mean abdominal circumference of 104 cm (± 12.94).
Office Blood pressure (BP) was a mean systolic BP of 140mmHg (± 21.89), a mean diastolic BP of 73.08mmHg (± 13.79). Ambulatory blood pressure monitoring (ABPM) showed 24-hour systolic BP of 136mmHg (±13.57), 24-hour diastolic BP of 73.03mmHg (12.53), daytime systolic BP (±15.39), daytime diastolic BP 76.1mmHg (±14.4), nocturnal systolic BP 127mmHg (±13.31) and nocturnal diastolic BP 66.79 (±10.24).
Regarding personal history, 11% had active smoking and up to 22% had moderate alcoholism; 30% said they were active in physical exercise.
As with other antecedents, half of the patients were also diagnosed with dyslipidemia (PLD), 20% with diabetes mellitus (DM) and 16% with obstructive sleep apnoea (OSA). Up to 36% of the total had had previous cardiovascular events, and 77% were already undergoing antihypertensive treatment at the time of the echocardiogram.
Mean values of glucose 104.39 g/dL (± 24.11), triglycerides 146.24mg/dL (± 75.19), total cholesterol 188.58mg/dL (± 41.67), LDL cholesterol 117.23mg/dL (± 32.49), HDL cholesterol 50.57mg/dL (± 13.1) were observed.
2 patients presented cardiovascular event at one year in the form of coronary artery disease and arrhythmia, respectively). Mortality at 12 months was 0%.

Conclusions:
RWT is very frequent in older hypertensives in our sample. Our patients presented BP levels above guidelines recommended goal. A comprehensive approach to search for HMOD is recommended
CARDIAC AND HEPATIC DYSFUNCTION IN HYPERTENSIVE PATIENTS BY ASSOCIATION OF LIVER FIBROSIS INDICES 4 AND 5
Authors: Tatar Maria Cristina , German-sallo Marta , Runcan Dan Petrisor 
Published: May 2024

Objective:
To study heart failure in close relation with left ventricular ejection fraction, NT-proBNP, as well as hepatic impairment by calculating liver fibrosis index (FIB-4 and FIB-5) in hypertensive patients admitted to our internal medicine clinic.

Design and method:
We studied 500 patients diagnosed with heart failure (HF), admitted to our internal medicine clinic between 2022-2023 with a mean age of 72.12 years. We selected 460 patients previously diagnosed with hypertension out of 500 (92% with hypertension) of which 46.09% were female and 53.91% male. Left ventricular ejection fraction (LVEF) was analysed by echocardiographic determination in different types of HF. Liver function was assessed based on the formulas of FIB-4 [Age (year) × AST (IU/l)]/[platelet count (× 109/l) × ALT (IU/l)1/2] and FIB-5 [albumin (g/l) × 0. 3 + platelet count (109/l) × 0.05 - alkaline phosphatase (IU/l) × 0.014 + AST/ALT ratio × 6 + 14], and data were taken from inpatient analyses. Correlations between FIB-4, FIB-5 and LVEF, respectively NT-proBNP were analysed using Spearman's nonparametric test. A p-value less than 0.05 was considered statistically significant.

Results:
The mean value of FIB-4 parameter was 1.80 ±0.42 while the mean of FIB-5 parameter was -11.6 ± 5.61. EF had a mean value in the whole studied group patients of 42.9 ± 2 towards 10.2. A significant correlation was demonstrated between LVEF in patients included in the entire group and the parameters FIB-4 (p=0.0008, 95% CI) and FIB-5 (p=0.0098, 95% CI). The same results were observed in patients previously diagnosed with hypertension regarding LVEF and FIB-4 (p=0.0016) as well as FIB-5 (p=0.0276). No significant correlation (p>0.05) was found between the mean value of NT-proBNP (5890.94 pg/mL) and FIB-4/FIB-5 indices in patients with HF regardless the presence of hypertension.

Conclusions:
In HF patients previously diagnosed with hypertension, decreasing EF will result in a significant increase in liver fibrosis risk, but we didn’t observed the same trend regarding the biomarkers for HF. Further research is needed in order to analyse the link between LVEF, NT-proBNP and liver fibrosis indices
INAPPROPRIATE PULSE WAVE VELOCITY TO BLOOD PRESSURE LEVEL: DEFINITION AND CLINICAL DETERMINANTS
Authors: Setjiadi Dellaneira , Delles Christian , Boutouyrie Pierre , Bruno Rosa -MARIA 
Published: May 2024

Objective:
This study aims to quantify the proportion of population with inappropriate arterial stiffness measured by pulse wave velocity (PWV) and BP level including its associated characteristics.

Design and method:
This observational monocentric cohort study utilised data from Hôpital européen Georges-Pompidou (HEGP), Assistance Publique-Hôpitaux de Paris (APHP) that includes 5,186 (57.2% male, mean age 53 years) participants. 1,203 participants had a second PWV measurement. Residuals from log-transformed piecewise regression model for PWV prediction based on mean BP values were employed to define participants with inappropriate PWV. A multinomial regression analysis was conducted to find the associated clinical characteristics.

Results:
There are 522 participants with inappropriately high PWV and 517 participants with inappropriately low PWV, defined as 10th and 90th percentile of residuals. In the multinomial analysis, younger age, higher body mass index (BMI), and presence of diabetes mellitus (DM) are associated with inappropriately high PWV group. In participants with follow-up visit (n = 1,203), we found that classification into groups of inappropriate PWV was consistent, with 78% concordance.

Conclusions:
This study generates a classification method to define inappropriate HMOD compared to BP levels. Screening especially of younger patients for HMOD irrespective of their BP level may lead to early detection of organ damage and identifications of patients for targeted preventive strategies.
ARTERIAL HYPERTENSION IN CHRONIC HEMODIALYSIS
Authors: Riguen Mouna , Fendri Beya , Kmicha Erij Ben , Abid Hanen , Dammak Najla , Agrebi Ikram , Chaker Hanen , Yaich Soumaya , Kammoun Khawla , Toumi Salma , Hmida Mohamed Ben 
Published: May 2024

Objective:
High blood pressure is widespread among individuals undergoing hemodialysis and is considered a significant contributor to the elevated cardiovascular mortality observed in this population. The aim of our study was to assess the prevalence of HTN and investigate its contributing factors.

Design and method:
This is a retrospective descriptive and analytic study conducted within our hemodialysis unit, including 70 patients. For each participant, the following clinical data were collected: age, gender, personal medical history, initial nephropathy, dialysis vintage, and evolution

Results:
Our study revealed a hypertension (HTN) prevalence of 51,4%. Among them, 63,9% were male, resulting in a sex ratio of 1,76. The mean age was 49.1 years (range: 21-86 years). undetermined nephropathy was the predominant initial nephropathy (39%). The average blood pressure of hypertensive patients was 159 mmHg for systolic (142-189 mmHg). Diabetic patients were more hypertensive with no statistically significant difference. Hypertensive patients exhibited a larger waist circumference, lower hemoglobin levels, and a lower left ventricular ejection fraction (LVEF) with no statistically significant difference. hypertensive patients were more prone to cardio vascular events such Cerebrovascular Accidents (2% of patients), transient ischemic attacks (2% of patients), and coronary artery disease (11% of patients).

Conclusions:
In summary, our study emphasizes the importance of investigating hypertension and its related factors, aiming to contribute insights for better cardiovascular health management.
VASCULAR FUNCTION CHANGES IN NONALCOHOLIC FATTY LIVER DISEASE (NAFLD)/ NONALCOHOLIC STEATOHEPATITIS
Authors: Jafari Kaveh , Paquet Véronique , Addour Saliha , Fortie Catherine , Trépan Gabrielle , Ferlan Stéphanie , Agharazii Mohsen , Carre Anne -MARIE 
Published: May 2024

Objective:
The main cause of death among patients with NAFLD is cardiovascular disease. It is firmly established that NAFLD is major risk factors for cardiovascular diseases and Aortic stiffness is an independent predictor of cardiovascular events. Understanding this relationship aids in identifying potential risks and developing targeted interventions, ultimately improving preventive care strategies for individuals with NAFLD. Through the global approach, we investigate to examine the link between the severity of metabolic steatosis and the various indices of vascular function.

Design and method:
Patients followed consecutively at the University Hospital of Quebec were recruited to participate. We assessed aortic stiffness, brachial stiffness, Global stiffness, Intima-Media Thickness and the flow-dependent vasodilation (FMD). The participants were divided according to the stage of hepatic steatosis, either early or advanced.

Results:
In this study, we had 50 patients. Thirteen of them were in the early NASH group, with an average age of 65.1 ± 11.0, and 37 patients were in the advanced NASH group, with an average age of 54.0 ± 12.4. According to the classification into early and advanced NASH, there was a significant difference in brachial diastolic pressure between the two groups (69.2 ± 8.7 vs. 75.3 ± 8.0; P = 0.02). Regarding carotid artery remodeling parameters, static circumferential wall stress was higher in the advanced NASH group (69.2 ± 15.1 vs. 86.4 ± 20.5; P < 0.01), while the Wall-to-Lumen Ratio was lower among the advanced NASH patients (0.095 ± 0.02 vs. 0.078 ± 0.01; P < 0.01). Patients in the advanced stage had smaller intima-media thickness, and the artery diameter became wider (0.652 ± 0.169 vs. 0.555 ± 0.097; P < 0.05).

Conclusions:
In this preliminary analysis, there were no associations between the severity of NASH and markers of arteriosclerosis, atherosclerosis and endothelial dysfunction. However, advanced NASH was associated with a hypotrophic remodeling of the common carotid artery (large elastic vessel), even after adjustment for age, diastolic BP, and sex. In a similar manner, the diameter of the brachial artery (medium-sized muscular vessel) seemed to be higher with advanced NASH.
THE INFLUENCE OF EXTREME DIPPING PRESSURE ON LEFT VENTRICULAR HYPERTROPHY IN GENERAL POPULATION
Authors: Zou Hang , Diao Jiayu , Yan Ju , Gou Qiling 
Published: May 2024

Objective:
Extreme dipping pressure, characterized by a nighttime decrease of over 20% compared to daytime levels, lacks consensus regarding its influence on cardiac structure and function. Particularly in the general population, there's limited research on this common blood pressure pattern. This study aims to investigate the relationship between extreme dipping pressure and cardiac structure and function in a general population.

Design and method:
We conducted 24-hour ambulatory blood pressure monitoring in 673 individuals without hypertension to assess blood pressure patterns. We analyzed the association between extreme dipping pressure and left cardiac structure, left ventricular hypertrophy (LVH), and left ventricular diastolic function.

Results:
Using a criterion of a nighttime decrease of over 20% in systolic and/or diastolic blood pressure, extreme dipping pressure was observed in 15.8% (107/673) of the general population. LVH prevalence in this study was 18.9% (127/673), with extreme dipping, non-dipping, and dipping patterns observed in 12.6%, 39.4%, and 48.0%, respectively, in the LVH group. In the non-LVH group, these patterns were observed in 16.5%, 47.8%, and 35.7%, respectively. A significant difference in distribution between different blood pressure patterns existed between the LVH and non-LVH groups (p=0.19). Univariate analysis indicated that, compared to the non-dipping pattern, extreme dipping was a protective factor for LVH occurrence (p=0.045, OR 0.173, 95%CI 0.031-0.959). Even after adjusting for factors such as gender, age, BMI, left ventricular size, interventricular septum thickness, left ventricular posterior wall thickness, and overall blood pressure, extreme dipping remained a protective factor for LVH occurrence (p=0.019, OR 0.187, 95%CI 0.046-0.756).

Conclusions:
Our study indicates that extreme dipping pressure is relatively common in the general population and is closely associated with LVH occurrence. In the general population, extreme dipping independently reduces the occurrence of LVH.