bluuebunny/crossref_metadata_2025_split huggingface dataset:
Znane i nieznane. Źródła ikonograficzne związane z uroczystościami ku czci Napoleona organizowanymi przez Polaków w dobie Księstwa Warszawskiego
Authors: Polaczek Janusz 
Published: June 2024

Epoka napoleońska, choć owiana legendą, nie pozostawiła po sobie nazbyt bogatej współczesnej dokumentacji ikonograficznej. Z rzadka tylko mamy do czynienia z nowymi, dotąd niepublikowanymi, źródłami. Do takich niewątpliwie należy obraz przedstawiający „Uroczystość NAPOLEONA WIELKIEGO Wskrześcy Polaków Dnia 13 (sic!) Sierpnia 1812 R[ok]u pod przewodnictwem JW Stanisława Wodzickiego Prefekta”. Reprodukcja tego dzieła niedawno opublikowana została na stronie internetowej PAUart. Wedle wszelkiego prawdopodobieństwa chodzi tu o pracę Michała Stachowicza. Można przypuszczać, że powstała ona na zamówienie publiczne. Miała zapewne upamiętniać deklarację, jaką w sprawie odbudowy Królestwa Polskiego złożył Napoleon w Wilnie 11 lipca 1812 r. Trudno dziś rozstrzygnąć, czy obraz ten miał stanowić wzór do niezrealizowanej ryciny, czy też jako dzieło malarskie upamiętniać, w którymś z obiektów publicznych wiekopomny moment. W tym ostatnim przypadku należałoby ją traktować jako krakowski odpowiednik (choć skromniejszy w formie) warszawskiego projektu ulokowania w Sali Senatu Zamku Królewskiego tablicy-pomnika Napoleona. Na nim też miała zostać umieszczona inskrypcja zawierająca wyjątek ze wspomnianej deklaracji złożonej przez cesarza w Wilnie. Krach kampanii 1812 r. spowodował, że Polacy o podobnych upamiętnieniach zaczęli myśleć od nowa, tyle że w odniesieniu do cara Aleksandra I. Historia kołem się toczy.
Patients with Fontan circulation: long-term complications and follow-up strategy
Authors: Kharakterova E. V. , Ivanilova A. A. , Fetisova S. G. , Kulpina A. Ya. , Kofeynikova O. A. , Vershinina T. L. , Pervunina T. M. , Vasichkina E. S. 
Published: June 2024

The Fontan operation is a palliative surgical correction, which is performed on children with congenital heart defects (CHD) in cases when surgical creation of two equally working ventricles is impossible. Today there are about 70,000 patients with Fontan circulation all over the world. Due to improvement of methods in early detection and treatment of CHD, as well as monitoring algorithms, an increasing number of patients with a single ventricle (SV) stay alive until adulthood.However, this group’s mortality is still quite high, despite the constant development of the surgery approach using modern technical equipment and high-tech examination methods. Chronic increase in systemic venous pressure, non-physiological passive pulmonary blood flow and progressive heart failure (HF) with a decreasing cardiac output (CO) gradually lead to complications from other organs and systems. That is why a multidisciplinary approach and development of optimal management tactics are required to follow-up patients with Fontan hemodynamics.Thus, the purpose of our work was to analyze and summarize current data of the management strategy and timely diagnosis complications in patients with Fontan circulation.
Blinatumomab in pediatric acute lymphoblastic leukemia: one center experience
Authors: Muliarova N. V. , Smirnova A. Yu. , Lapaeva S. I. , Toshina Yu. K. , Dinikina Yu. V. 
Published: June 2024

Background. Despite the successes achieved in the treatment of B-cell acute lymphoblastic leukemia (B-ALL), overcoming the toxicity of standard chemotherapy regimens and the treatment of relapsed/refractory (r/r) forms of the disease remains relevant. The most promising option is to use immunotherapy (IT), including a monoclonal antibody blinatumomab (BM). The purpose of the study. To analyze indications of using, as well as efficacy and tolerability of BM in children with V-ALL. Materials and methods. From April 2016 to January 2024 a retrospective assessment of using of BM in children with B-ALL in the chemotherapy department of oncohematological diseases and TCM for children in Almazov National Medical Research Centre was performed. Results. The study included 53 patients, including 28 (53 %) girls and 25 (47 %) boys with median age of 7,7 (2,08–19,8) years. Indications for using of BM were as follows: (1) consolidation of remission (CR) with primary ALL (n = 17, 32 %); (2) persistence of minimal residual disease (MRD) (n = 23, 43 %) after completion of chemotherapy (CT) induction or before the stage of allogeneic haematopoietic stem cell transplantation (alloHSCT); (3) replacement of the standard CR due to the previous toxicity of СT or other contraindications to its implementation (n = 12, 23 %); (4) salvage therapy for r/r ALL (n = 1, 1,9 %). The status of MRD-negative remission after the 1st course of IT was achieved in 89 % of cases. Therapy using BM in a patient with the r/r ALL and total blast infiltration of the bone marrow was effective and facilitated reducing the tumor population to 7,2% by day 15 of therapy, however, there was a fatal outcome due to development and progression of preexisted severe infection. The most common variants of grade III–IV toxicity were leuko-/neutropenia (28 %) and neurotoxicity (3,7 %). BM dose reduction for the purpose of relieving toxicity was required in 19 % of patients, while the median days of therapy with dose reduction was 4. Corticosteroids were used for this purpose in 11 % of cases, antibacterial therapy — in 13 %. At the time of results evalution, there were no relapses of the disease in the study group. The article analyzes the international experience of using BM in patients with B-ALL.Conclusion. Our experience and the presented literature data demonstrate a reasonable expansion of indications for using of BM in children with B-ALL with high efficacy and satisfactory toxicity profile.
Cybersecurity strategy: future proof cybersecurity for small to medium enterprises in South Africa
Authors: Mugwagwa Audecious , Bhero Ernest , Chibaya Colin 
Published: June 2024

Technological development has witnessed tremendous and an increase in business interactions as they execute their daily business. Information technology and broadband are significant drivers of productivity and efficiency growth for small firms as they expand their market. This development has raised growing concerns as it relates to data and information security, infrastructure, and related resources due to an increase in cybersecurity hazards faced by Small to Medium Enterprises globally. In South Africa, although, during the first four months of 2022, cyber-attacks decreased by 13% to account for 419506 internet attacks, this statistic remains high enough for concern. To counter escalating cybersecurity risks, organizations must have a cybersecurity strategy to safeguard their operations, clients, data, and infrastructure. The threat landscape is changing over time, and despite ongoing attempts to strengthen security, they don't appear to be enough to prevent evolving cyberattacks. The study aims to identify cybersecurity threats facing Small to Medium Enterprises in South Africa by reviewing the literature and identifying key Cybersecurity challenges. It also examines the strategies, resources, and techniques used in South Africa to reduce cybersecurity threats. Lastly, the paper recommends adopting a comprehensive Cybersecurity strategy to build future-proof cybersecurity for Small to Medium Enterprises in South Africa.
Neural Network Sales Revolution Outperforms Exponential Smoothing
Authors: Sari Safia Meilia , Sari Wulandari Indah Apriliana 
Published: June 2024

This research addresses the challenges faced by food manufacturing companies, focusing on UD. XYZ as a case study. With fluctuating sales levels causing raw material buildup and shortages, the study proposes an improved sales forecasting method to enhance raw material control. By comparing Artificial Neural Network (ANN) and Double Exponential Smoothing Holts, the research aims to optimize inventory management and production processes. Results indicate ANN's superiority over Holts, with an accuracy rate of 0.118 compared to 11.639. The ANN model accurately forecasts sales for the upcoming twelve-month period, highlighting a decline from July 2023 to May 2024. Implementing advanced forecasting methods can mitigate raw material-related risks and enhance operational efficiency for companies like UD. XYZ.
Highlight:

Enhanced sales prediction methods crucial for inventory planning.
Artificial Neural Network outperforms traditional forecasting techniques.
Improved forecasting mitigates raw material shortages and excesses.

Keywoard: Sales forecasting, Artificial Neural Network, Raw material control, Inventory management, Production optimization.
Smart Stick Revolutionizes Mobility for the Visually Impaired
Authors: Alfian Moh. , Ayuni Shazana Dhiya 
Published: June 2024

Visual impairment significantly hinders daily activities, necessitating innovative solutions. This study develops and tests a smart walking stick using NodeMCU ESP-8266, HCSR-04 ultrasonic sensor, DFPlayer, and GPS, monitored via the Blynk app. Employing a research and development approach, the device demonstrated 100% accuracy in obstacle detection and location tracking, providing real-time feedback through audio notifications and smartphone monitoring. This smart walking stick enhances mobility and safety for visually impaired users, representing a significant advancement in assistive technology.
Highlights:

Accurate Obstacle Detection: 100% accuracy with HCSR-04 ultrasonic sensor.
Real-time Monitoring: GPS tracking via Blynk app.
Enhanced Mobility: Increases safety and independence for visually impaired users.

Keywords: Visual impairment, Smart walking stick, Ultrasonic sensor, GPS tracking, IoT
Revitalizing Customer Satisfaction in Indonesia's Rice Industry
Authors: Pratama Muchammad Ikbal , Sulistiyowati Wiwik , Cahyana Atikha Sidhi , Putra Boy Isma 
Published: June 2024

CV. Central Karya Jaya, a rice distribution company, faced a 40% profit decline. This study aims to enhance company performance and customer satisfaction using the Balanced Scorecard and Importance Performance Analysis (IPA). Data from 70 respondents showed a financial ROE above 12%, but customer satisfaction had a 72.25% conformity, revealing unmet needs. Key improvements are needed in managerial friendliness, employee responsiveness, and personalized service. Recommendations include fostering better employee relations and understanding customer needs, with future research suggesting the use of Quality Function Deployment (QFD) for further service enhancement.
Highlights:

Financial Performance: ROE above 12% indicates solid financial health.
Customer Satisfaction: 72.25% conformity shows areas needing improvement.
Key Improvements: Enhance managerial friendliness and employee responsiveness

Keywords: Performance Measurement, Balanced Scorecard, Customer Satisfaction, Rice Distribution, Importance Performance Analysis
ʿAlāʾ al-Dīn al-Bājī's (d. 714/1314) critique of the Pentateuch and the plurality of Christian Bible recensions
Authors: Adang Camilla , Hjälm Miiram 
Published: June 2024

The present article discusses the Muslim legal scholar and theologian al-Bājī (b. 631/1233) and his polemic against the Pentateuch, which he read in at least two Christian Arabic translations, which were in use among the Melkites. It aims to identify the recensions of the Pentateuch that al-Bājī had access to, and to understand how the differences between these recensions contributed to his view that the shared Jewish and Christian scripture had undergone changes. The article suggests that al-Bājī used a combination of arguments to undermine especially the Christian conception of divine revelation, pointing out apparent inconsistencies and illogicalities in the biblical stories themselves as well as text-critical cruxes caused by discrepancies between different versions that circulated side by side within the Eastern Christian communities. Finally, some of the “irrationalities” he describes seem to be particular of the copies of the texts he had in front of him.
Manufacture of configurable equipment of thin-film deposit by SILAR with magnetic stirring.
Authors: Guerrero-Osuna Héctor Alonso , Martell-Puente Herbert , Sigala-Valdez Jesús Octavio , Solis-Sánchez Luis Octavio , Rojas-Briseño José Guadalupe , Santiago Antonio Del Rio-De 
Published: June 2024

Abstract

For the deposition of thin films by SILAR method, a robotic device was developed, with a low-cost microcontroller Arduino nano, a rotary encoder, and a LCD20X4 screen for the user interface in which a series of menus deploys allowing the selection of the process in order to synthesize a semiconductor, parameters of SnO2, CdS, ZnS and MnS are previously loaded obtaining reproducibility and minimizing errors, especially in series of many samples. The system is independent of a computer, giving more possibilities for transportation; if the process requires heating and stirring, it is included in the device and its control. A glass slide was used as substrate in six repositories for recipients of 35 ml, thus producing samples without excessive waste of precursors; initially six recipients are included in the system, the number of recipients can be increased taking in consideration the length of the rail, which opens the possibility to deposit multilayer films in a single process, with the condition to occupy the same anionic precursor. This aims for better grain boundaries, less contamination between layers of a device, self-doping, and reduced secondary phases. We report the making of our own SILAR equipment and characterization of SnO2 films deposited on glass slices by Uv-Vis spectrophotometer determined a characteristic absorption edge at 350 nm, four-point "Kelvin" method for electrical properties obtaining average electrical resistance of 16×103(Ω), and Scanning Electron Microscope images for superficial morphology, clarifying the use of this material as a transparent conductive oxide.
Do agricultural practices on meadows reduce or increase flight initiation distance in the White Stork Ciconia ciconia?
Authors: Kasprzykowski Zbigniew , Golawski Artur 
Published: June 2024

Abstract

Human activities often negatively affect the time birds spend on activities such as parental care, foraging and resting. Forms of antipredator behaviour among birds such as vigilance can be an adaptation to human disturbances which can enhance their fitness in human‐managed habitats. We studied the flight initiation distance (FID) of White Storks Ciconia ciconia foraging on hay meadows during their breeding season. Our study showed that farm work, the type of meadows and starting distance (the distance between the bird’s position and the observer at the start of his walk) all had an influence on FID. Conversely, the numbers of storks in a particular foraging flock had no effect on an individual bird’s FID. The lower FID could have been due to the presence of machinery operating in the meadows, because storks then have opportunities to catch energy-rich prey that has been scared off by the machines. Unlike meadows cleared of hay, mown meadows with cut grass are more attractive to storks, and the FID there is shorter. The starting distance positively affected stork responses. These findings suggest that the FID of White Storks, treated as a measure of the risk of predation, depends largely on the degree of attractiveness of the feeding grounds.
Association of pulmonary artery systolic pressure with inflammatory factors among pediatric congenital heart disease with pulmonary arterial hypertension after cardiopulmonary bypass
Authors: Li Wen-juan , Shang Wen-yuan , Huang Ji-hong 
Published: June 2024

Abstract

Background
This study aimed to evaluate the perioperative circulating levels of inflammatory cytokines in pediatric patients with pulmonary arterial hypertension (PAH) secondary to congenital heart disease (CHD) patients, and also sought to investigate the correlation between preoperative echocardiographic pulmonary artery systolic pressure (PASP) and inflammatory factor levels after cardiopulmonary bypass (CPB) in these patients.
Methods
A retrospective observational study was conducted involving 59 children under 2 years old. Echocardiography was used to measure tricuspid annular peak systolic velocity (TRV). The levels of perioperative inflammatory cytokines in the plasma, including IL-6, IL-8, IL-10, IL-1β, and TNF-α, were measured. Additionally, postoperative ventilation time, length of intensive care unit (ICU) stay, and ward stay were recorded.
Results
PAH-CHD patients showed longer postoperative ventilation time, ICU stay, and ward stay. There was a more significant increase in postoperative inflammatory cytokines, including IL-6, IL-8, and IL-10 after CPB in PAH-CHD patients compared to no PAH-CHD patients (p < 0.05). Preoperative echocardiographic PASP was identified as being associated with the levels of IL-6 and IL-10 after surgery in PAH-CHD patients, and PASP ≥ 52mmHg could predict ventilation time exceeding 21 hours after surgery.
Conclusion
Higher levels of inflammatory cytokines were observed in pediatric patients with PAH-CHD after CPB. Additionally, preoperative high echocardiographic PASP was associated with elevated postoperative inflammatory factors in these patients, indicating a potential correlation with unfavorable early postoperative clinical outcomes.
Trastuzumab Deruxtecan in brain metastases from breast cancer: outcome analysis of real life population
Authors: Rossi Alessandro , Fabi Alessandra , Caputo Roberta , Pisegna Simona , Scagnoli Simone , Pantano Francesco , D'Auria Giuliana , Fedele Palma , Fabbri Agnese , Vernieri Claudio , Palleschi Michela , Carbognin Luisa , Ferretti Gianliugi , Monte Elena Di , Paris Ida , Pavese Francesco , Garrone Ornella , Franco Antonio , De Laurentiis Michelino , Franceschini Gianluca , Scambia Giovanni , Giannarelli Diana , Masetti Riccardo , Botticelli Andrea 
Published: June 2024

Abstract

Introduction. Tumor dissemination to the central nervous system (CNS) is almost a rule in the treatment journey of advanced HER2+ breast cancer (BC). Recent results from the DEBBRAH and TUXEDO trials demonstrated high intracranial efficacy with Trastuzumab Deruxtecan (T-Dxd), confirmed by a pooled analysis of DESTINY-BREAST 01, 02, and 03 trials. However, a real world evidence is lacking in literature.
Methods. We conducted a multicenter, observational, and retrospective real-world analysis on cases collected at 12 Italian Oncological Units. Patients with brain metastases (BMs) from HER2+ BC treated with T-Dxd in various treatment lines were enrolled. Data were extrapolated from the original DE-REAL study database. Primary endpoint was the intracranial overall response rate (iORR). The main secondary endpoints were intra- and global progression free survival (iPFS - gPFS); Other secondary objectives were the intracranial disease control rate (iDCR), intracranial duration of response (iDoR), the intracranial clinical benefit rate at 6 and 12 months (iCBr), the overall survival, and the safety.
Results. 39 patients were included in the final analysis. iORR was 59% (23), iPFS was 15.6 months (95% CI: 10.5-20.8), gPFS was 11.8 months (95% CI: 8.5-15.0). i DCR 94.9% (87.9-100.0), iDoR was 11.9 months (10.1-13.7), and iCBr at 6 and 12 months were 69.2% and 59%, respectively. OS was not reached, with an overall rate of 77.9% of patients alive at 12 months. No new safety concerns were reported.
Conclusions. This study confirmed the high intracranial efficacy and manageable safety profile of T-Dxd in this first-ever real world analysis.
Synaptotagmin-1 attenuated myocardial programmed necrosis and ischemia/reperfusion injury through the mitochondrial pathway
Authors: Cao Jimin , Sun Teng , Li Jialei , Wang Shuang , Han Yu , Tao Xiangyu , Yuan Min , Jing Zhijie , Liu Ting , Qi Yuehong , Liu Siqi , Feng Yanlin , Chang Jiasong , Zhou Lan , Gao Lijuan , Shi Jianyun 
Published: June 2024

Abstract

Programmed necrosis/necroptosis greatly contributes to the pathogenesis of cardiac disorders including myocardial infarction, ischemia/reperfusion (I/R) injury and heart failure. However, the fundamental mechanism underlying myocardial necroptosis, especially the mitochondria-dependent death pathway, is poorly understood. Synaptotagmin-1 (Syt1), a Ca2+ sensor, is originally identified in nervous system and mediates synchronous neurotransmitter release. The later findings of Syt1 expressions in many non-neuronal tissues including muscles suggest that Syt1 may exert important functions beyond regulation of neurotransmitter release. Syt1 is highly expressed in cardiomyocytes and has been used as an extracellular molecular probe for SPECT imaging of cardiac cell death in acute myocardial infarction. However, whether Syt1 functions in the pathogenesis of cardiac disorders and what is the molecular etiology have not yet been clarified. We showed here that Syt1 expression was significantly down-regulated in mice I/R injured heart tissues and H2O2-challenged cardiomyocytes. Enforced expression of Syt1 significantly inhibited myocardial necrotic cell death and interstitial fibrosis, and improved cardiac function in mice subjected to I/R operation. In exploring the underlying mechanisms, we found that Syt1 interacted with Parkin and promoted Parkin-catalyzed CypD ubiquitination, thus inhibited mitochondrial membrane permeability transition pore (mPTP) opening and ultimately suppressed cardiomyocyte necrosis. We further found that Syt1 expression was negatively regulated by miR-193b-3p. MiR-193b-3p regulated cardiomyocyte necrosis and mPTP opening by targeting Syt1. Our present work revealed a novel regulatory model of myocardial necrosis composed of miR-193b-3p, Syt1, Parkin, and CypD, which may provide potential therapeutic targets and strategies for heart protection.
Psmb8 inhibits mitochondrial fission and alleviates myocardial ischaemia/reperfusion injury by targeting Drp1 degradation
Authors: Li Hui-Hua , Su Hui-Xiang , Xu Luo-Luo , Li Pang-Bo , Bi Hailian , Jiang Wen-Xi 
Published: June 2024

Abstract

The mitochondrial dynamic imbalance is an important cause of myocardial ischaemia/reperfusion (I/R) injury and dysfunction. Psmb8, as one of the immunoproteasome catalytic subunits, is a key regulator of protein homeostasis, inflammation and some cardiac diseases. Here, we found that the expression level and activity of Psmb8 were significantly reduced in I/R mice and in subjects with myocardial infarction. Cardiomyocyte-specific Psmb8 overexpression in mice markedly ameliorated I/R-mediated cardiac injury and dysfunction, which was accompanied by reduced mitochondrial division via the downregulation of dynamin-related protein-1 (Drp1). However, Psmb8 knockout (KO) mice exhibited the opposite changes. The effects of Psmb8 on mitochondrial fission and apoptosis was confirmed in primary cardiomyocytes with overexpression or knockdown of Psmb8 in vitro. Mechanistically, Psmb8 was directly associated with Drp1 and enhanced its degradation, which subsequently suppressed I/R-mediated mitochondrial fission and cardiac injury. Conversely, knockdown of Drp1 in Psmb8-KO mice restored I/R-induced cardiac dysfunction and mitochondrial dynamic imbalance. Our study identified a new cardioprotective role of Psmb8 in cardiac I/R damage through targeting Drp1, and highlight that increasing Psmb8 activity may constitute a promising therapy for ischaemic heart disease.