bluuebunny/crossref_metadata_2025_split huggingface dataset:
MANAGEMENT OF FAILED TOTAL ANKLE ARTHROPLASTY AND MASSIVE BONE CYSTS USING IMPACTION BONE GRAFTING AND THE INVISION TOTAL ANKLE REVISION SYSTEM
Authors: Gordon C. , Raglan M. , Dhar S. , Lee K. 
Published: June 2024

ObjectiveThe purpose of this study was to determine the outcomes of revision ankle replacements, using the Invision implant and impaction allograft for massive talar dome defects following primary ankle replacement failure. Outcomes were assessed in terms of bone graft incorporation; improvement in patient reported outcome measures (PROMs); and survivorship of the revision ankle arthroplasty.MethodsA retrospective review of prospectively collected data identified eleven patients who had massive bone cysts and underwent revision of a failed primary total ankle replacement to the Invision revision system, combined with impaction grafting using morselized femoral head allograft. These revisions occurred at a single high volume ankle arthroplasty centre. Computed tomography (CT) scans were used to assess bone graft incorporation and the Manchester-Oxford Foot Questionnaire (MOXFQ) and EQ-5D scores were used pre and post operatively to assess PROMs.ResultsThe mean follow up was 18 months (12–48months). In all eleven patients, improvement was reported in the post-operative MOXFQ and EQ-5D scores. CT scans showed bone graft incorporation in all cases. None of the patients have required further surgery and are continue to do well clinically at latest follow up.ConclusionsIn the short term, this study confirms revision ankle replacements with the Invision prosthesis and impaction with morselized femoral head allograft is a suitable revision option for primary ankle replacement failure with massive talar bone loss. Long term follow up continues of these complex patients.
Reproductive and child health transition among selected empowered action groups states of India: A district-level analysis
Authors: Pandey Bindhy Wasini , Yadav Ganesh , Tripathi Niharika , Pathak Praveen Kumar 
Published: June 2024

Background
Health is an inseparable part of life and central to all life supporting systems. The reproductive and child health shares a major portion of public health cases that is crucial for socio-economic development. Studies on reproductive and child health have traditionally been focused on demographic aspects using socio-economic parameters. Given the emphasis of Sustainable Development Goal (SDG)-3 on health and well-being, it is imperative to understand the geo-spatial dimension with the visible transition of key health indicators of fertility, maternal and infant/child health in the high burdened districts within these high focus Empowered Action Group (EAG) states of Rajasthan, Madhya Pradesh, Uttar Pradesh and Bihar that make up nearly 40% of India’s population with relatively laggard health status.

Methodology
This paper aims to understand the status and trend of key reproductive and child health indicators and vital statistics based on the recent representative demographic surveys. We intend to undertake a district level spatio-temporal analysis by developing District Composite Health Profile (DCHP) using Composite Index Method on selected 13 equally weighted key reproductive and child health indicators. The study has been carried out using data from National Family Health Survey-4 (2015–16) and National Family Health Survey-5 (2019–21) survey rounds. We employed geo-spatial techniques i.e. Moran’s–I, and univariate LISA to comprehend the geographical clustering of high and low health burden districts and their heterogeneities at the district level.

Results/Conclusions
The study highlights emerging inter-districts, and inter-state disparities over survey periods. With consistent improvement in the selected EAG states over time, the overall reproductive and child health status through DCHP along with each indicator was relatively better in the states of Rajasthan and worse in Bihar. Districts along the Terai belt in Uttar Pradesh and Bihar consistently performed sluggish during survey rounds. The geo-spatial clustering follows the political boundary of states, albeit with intra-state variations. Monitoring of key health indicators using composite index method provides a useful leverage for identifying priority districts/regions for universal health access that should also consider geographical space as an important policy dimension.
The causal relationship between autoimmune diseases and age-related macular degeneration: A two-sample mendelian randomization study
Authors: Li Linrui , Zhang Mingyue , Gu Moxiu , Li Jun , Li Zhiyuan , Zhang Rong , Du Chuanwang , Lv Yun 
Published: June 2024

Objective
The aim of this study is to investigate the potential causal relationship between autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, and Type 1 diabetes, and age-related macular degeneration (AMD). By utilizing the two-sample Mendelian Randomization (MR) approach, we endeavor to address this complex medical issue.

Methods
Genome-wide association study (GWAS) data for autoimmune diseases and AMD were obtained from the IEU Open GWAS database and the FinnGen consortium. A series of stringent SNP filtering steps was applied to ensure the reliability of the genetic instruments. MR analyses were conducted using the TwoSampleMR and MR-PRESSO packages in R. The inverse-variance weighted (IVW) method served as the primary analysis, complemented by multiple supplementary analyses and sensitivity tests.

Results
Within the discovery sample, only a statistically significant inverse causal relationship between multiple sclerosis (MS) and AMD was observed (OR = 0.92, 95% CI: 0.88–0.97, P = 0.003). This finding was confirmed in the replication sample (OR = 0.85, 95% CI: 0.80–0.89, P = 3.32×10−12). No statistically significant associations were detected between systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, and Type 1 diabetes and AMD.

Conclusion
Strong evidence is provided by this study to support the existence of an inverse causal relationship between multiple sclerosis and age-related macular degeneration. However, no causal evidence was found linking other autoimmune diseases with AMD. These findings not only offer novel insights into the potential etiological mechanisms underlying AMD but also suggest possible directions for future clinical interventions.
Cost-effectiveness analysis of granulocyte colony-stimulating factors for the prophylaxis of chemotherapy-induced febrile neutropenia in patients with breast cancer in Taiwan
Authors: Tseng Tzu-Hsuan , Chiang Shao-Chin , Hsu Jason C. , Ko Yu 
Published: June 2024

Objectives
To examine the cost-effectiveness of using granulocyte colony-stimulating factor (G-CSF) for primary or secondary prophylaxis in patients with breast cancer from the perspective of Taiwan’s National Health Insurance Administration.

Methods
A Markov model was constructed to simulate the events that may occur during and after a high-risk chemotherapy treatment. Various G-CSF prophylaxis strategies and medications were compared in the model. Effectiveness data were derived from the literature and an analysis of the National Health Insurance Research Database (NHIRD). Cost data were obtained from a published NHIRD study, and health utility values were also obtained from the literature. Sensitivity analyses were performed to assess the uncertainty of the cost-effectiveness results.

Results
In the base-case analysis, primary prophylaxis with pegfilgrastim had an incremental cost-effectiveness ratio (ICER) of NT$269,683 per quality-adjusted life year (QALY) gained compared to primary prophylaxis with lenograstim. The ICER for primary prophylaxis with lenograstim versus no G-CSF prophylaxis was NT$61,995 per QALY gained. The results were most sensitive to variations in relative risk of febrile neutropenia (FN) for pegfilgrastim versus no G-CSF prophylaxis. Furthermore, in the probabilistic sensitivity analysis, at a willingness-to-pay threshold of one times Taiwan’s gross domestic product per capita, the probability of being cost-effective was 88.1% for primary prophylaxis with pegfilgrastim.

Conclusions
Our study suggests that primary prophylaxis with either short- or long-acting G-CSF could be considered cost-effective for FN prevention in breast cancer patients receiving high-risk regimens.
Validation of the Arabic language version of the Audio Processor Satisfaction Questionnaire (APSQ) for hearing implant users
Authors: Alasmi Abdulaziz , Saleh Shaza , Anderson Ilona , Abdelsamad Yassin , Hagr Abdulrahman 
Published: June 2024

Objective
Audio processors (AP) are the external components of hearing implants. User satisfaction with the performance and comfort of their AP is a critical factor in ensuring daily use, which leads to improved hearing outcomes. The aim of this study was to construct and validate an Arabic language translation of the APSQ for use among Arabic-speaking clinicians and patients.

Design
The original APSQ was translated into the Arabic language using cross-cultural adaptation measures. The final questionnaire was administered to CI users in electronic form.

Study sample
117 CI users (64 female) participated. A total of 179 ears were assessed.

Results
High levels of satisfaction with audio processors were observed among CI users. Item and scale analyses indicate that this version of the APSQ measure a homogeneous and valid construct.

Conclusion
The Arabic version of the APSQ captures user satisfaction with hearing implant audio processors.
Naringin from Ganshuang granule inhibits inflammatory to relieve liver fibrosis through TGF-β-Smad signaling pathway
Authors: Wang Fuchun , Gan Jian , Li Rui , Yang Rui , Mao Xiaorong , Liu Shuang , Chen Yu , Duan Zhongping , Li Junfeng 
Published: June 2024

Objective
The present study aims to investigate the specific protective effects and underlying mechanisms of Ganshuang granule (GSG) on dimethylnitrosamine (DMN)-induced hepatic fibrosis in rat models.

Methods
Hepatic fibrosis was experimentally evoked in rats by DMN administration, and varying dosages of GSG were employed as an intervention. Hepatocellular damage was assessed by measuring serum levels of aminotransferase and bilirubin, accompanied by histopathological examinations of hepatic tissue. The hepatic concentrations of platelet-derived growth factor (PDGF) and transforming growth factor-β1 (TGF-β1) were quantitated via enzyme-linked immunosorbent assay (ELISA). The expression of α-smooth muscle actin (α-SMA) within hepatic tissue was evaluated using immunohistochemical techniques. The levels of hepatic interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), and a spectrum of interleukins (IL-2, IL-4, IL-6, IL-10) were quantified by quantitative real-time PCR (qRT-PCR). Additionally, hepatic stellate cells (HSCs) were cultured in vitro and exposed to TNF-α in the presence of naringin, a principal component of GSG. The gene expression levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) and matrix metallopeptidase-1 (MMP-1) in these cells were also quantified by qRT-PCR. Proliferative activity of HSCs was evaluated by the Cell Counting Kit-8 assay. Finally, alterations in Smad protein expression were analyzed through Western blotting.

Results
Administration of GSG in rats with fibrosis resulted in reduced levels of serum aminotransferases and bilirubin, along with alleviation of histopathological liver injury. Furthermore, the fibrosis rats treated with GSG exhibited significant downregulation of hepatic TGF-β1, PDGF, and TNF-α levels. Additionally, GSG treatment led to increased mRNA levels of IFN-γ, IL-2, and IL-4, as well as decreased expression of α-SMA in the liver. Furthermore, treatment with naringin, a pivotal extract of GSG, resulted in elevated expression of MMP-1 and decreased levels of TIMP-1 in TNF-α-stimulated HSCs when compared to the control group. Additionally, naringin administration led to a reduction in Smad expression within the HSCs.

Conclusion
GSG has the potential to mitigate fibrosis induced by DMN in rat models through the regulation of inflammatory and fibrosis factors. Notably, naringin, the primary extract of GSG, may exert a pivotal role in modulating the TGF-β-Smad signaling pathway.
A qualitative examination of the experiences and perspectives of interprofessional primary health care teams in the distribution of the COVID-19 vaccination in Ontario, Canada
Authors: Ashcroft Rachelle , Donnelly Catherine , Sheffield Peter , Lam Simon , Kemp Connor , Adamson Keith , Brown Judith Belle 
Published: June 2024

Background
Primary health care (PHC) teams contributed to all phases of the COVID-19 vaccination distribution. However, there has been criticism for not fully utilizing the expertise and infrastructure of PHC teams for vaccination distribution. Our study sought to understand the role PHC teams had in the distribution of the COVID-19 vaccine in Ontario, Canada. The key objective informing this study was to explore the experiences and perspectives of interprofessional PHC teams in the distribution of COVID-19 vaccination across Ontario.

Methods
A qualitative approach was used for this study, which involved 39 participants from the six health regions of the province. Eight focus groups were conducted with a range of interprofessional healthcare providers, administrators, and staff working in PHC teams across Ontario. The sample reflected a diverse range of clinical, administrative, and leadership roles in PHC. Focus groups were audio-recorded and transcribed, while transcriptions were then analyzed using thematic analysis.

Results
We identified the following four themes in the data: i) PHC teams know their patients; ii) mobilizing team capacity for vaccination, iii) intersectoral collaborations, and iv) operational challenges.

Conclusions
PHC teams were an instrumental component in supporting COVID-19 vaccinations in Ontario. The involvement of PHC in future vaccination efforts is key but requires additional resourcing and inclusion of PHC in decision-making. This will ensure provider well-being and maintain collaborations established during COVID-19 vaccination.
Prevalence of depression and associated factors among obstetric care providers at public health facilities in the West Arsi Zone, Ethiopia: Cross-sectional study
Authors: Alemu Solomon Seyife , Jarso Mohammedamin Hajure , Adem Zakir Abdu , Tesfaye Gebremeskel Mulatu , Workneh Yadeta Alemayehu , Gezimu Wubishet , Hussen Mustefa Adem , Gemeda Aman Dule , Teferi Sheleme Mengistu , Wedajo Lema Fikadu 
Published: June 2024

Background
Depression is a severe and treatable mental illness that significantly affects individuals’ daily activities. Obstetric care providers are the most vulnerable group for depression because they work in an emergency to save two lives at a time, share the stress of women during labor, and are at great risk for contamination.

Objectives
To assess depression and associated factors among obstetric care providers working in public health facilities.

Method and materials
A cross-sectional study was conducted among 423 obstetric care providers working in public health facilities found in the West Arsi Zone, Ethiopia, from June 1 to 30, 2023. Study participants were selected through a simple random sampling technique. A pretested, face-to-face interviewer-administered structured questionnaire was used to collect data. Bi-variable and multivariable logistic regression analyses were employed to identify factors associated with depression. The level of statistical significance was declared at P < 0.05 with a 95% CI.

Conclusions and results
Overall, the prevalence of depression among obstetric care providers was 31.1% (95% CI: 26.6%, 35.5%). Marital status not in union (AOR = 2.86, 95%CI: 1.66, 4.94), working more than 40 hours per week (AOR = 2.21, 95%CI: 1.23, 3.75), current substance use (AOR = 2.73, 95%CI: 1.64, 4.56), not being satisfied with their job (AOR = 3.52, 95%CI: 2.05, 6.07) and having burnout symptoms (AOR = 5.11, 95%CI: 2.95, 8.83) were factors significantly associated with depression.

Recommendations
We recommend that health professionals take care of themselves and avoid substance use. We also recommended that stakeholders enhance job satisfaction and avoid burnout by implementing various programs, like raising wages for workers, increasing staff members, offering various benefits, and regularly monitoring issues that arise.
SOCIOLOGICAL ASPECTS OF CONTENT AND CORRECTION OF JUNIOR CONVICTED IN THE IDEAL HERITAGE OF N. M. YADRINTSEV
Authors: Golovinov Alexandеr V. , Golovinova Yulia V. 
Published: June 2024

The purpose of this work involves a systematic reconstruction of the sociological views of the leader of the movement of Siberian regionalists - N. M. Yadrintsev on the problem of the regime of detention and mechanisms for the correction of juvenile delinquents. The relevance of the study is dictated by scientific, academic and practical tasks. Firstly, this fragment of the enlightenment’s ideological heritage has not yet received adequate coverage in literature. Therefore, the results of our work can contribute to the development of the subject area of the history of sociological thought in Russia. Secondly, the study can be useful in developing the doctrinal foundations of modern state penitentiary policy.
The work is based on the methodology of the “new social history” and the provisions of the “new intellectual history”, which allows us to consider social phenomena through the prism of the individual, and not the state. Textual analysis of N. M. Yadrintsev’s works on the stated topic was also widely used. In the course of the study, it was established that the Siberian thinker advocated the separation of juvenile prisoners from adult inmates and the establishment of a special regime of detention for this category of forced prisoners. The article notes that when considering the problem of keeping juvenile criminals in isolation from society, the Siberian regionalist recorded the consistent humanization of the criminal punishment itself for children. The authors also show that in the matter of re-education of juvenile convicts, the publicist proposed the speedy introduction of educational supervision for the purpose of moral influence on child criminals. In general, it is concluded that N. M. Yadrintsev developed a rational method of correction, which should be based on examples from social life that give concepts about the mutual connection of people.
The Impact of Firm Digital Transformation on Environmental, Social, and Governance Performance: Evidence from China
Authors: Luo Zixu 
Published: June 2024

Abstract
Growing consciousness about sustainability and the onset of the digital era have affected the corporate environmental, social, and governance (ESG) outcomes to the forefront of new debates. This article attempts to use statistical analysis software such as Stata to explore relevant issues. A-share listed firms in Shanghai and Shenzhen between 2006 and 2022 are examined in this research for the sake of exploring how digitalization in businesses affects ESG ratings. Findings suggest a positive correlation between digital initiatives and ESG metrics improvements. These findings are consistent even after multiple robustness checks. Additionally, this article delves into the mechanisms driving this primary relationship, discovering that digital advances in firms enhance ESG scores by easing financial limitations, diminishing information disparities, and bolstering technological innovation. This article further reveals variable impacts based on firm size and geographical location.
CD1d affects the proliferation, migration, and apoptosis of human papillary thyroid carcinoma TPC-1 cells via regulating MAPK/NF-κB signaling pathway
Authors: Liu Qingyuan , Zhai Tong , Ma Lei , Liu Qilun 
Published: June 2024

Abstract
The study aimed to investigate the effect of CD1d down-regulation on the proliferation, migration, and apoptosis of papillary thyroid carcinoma cells and explore the underlying mechanism. CD1d expression was silenced in TPC-1 cells by transfection of CD1d siRNA lentivirus. The proliferation, apoptosis rate, and migration ability of TPC-1 cells were detected by CCK-8 assay, flow cytometry, and scratch assay, respectively. Western blot and qPCR analyses were performed to detect the expression of related proteins. CD1d was highly expressed in TPC-1 cells. Down-regulation of CD1d significantly decreased ALMS1, CDKN3, CDK6, Ki-67, Bcl2 expression, increased Bax and Caspase 3 expression (all P < 0.05), and decreased the migration ability of TPC-1 cells. Gene ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed to identify the relevant signaling pathways. KEGG pathway enrichment analysis showed that the differentially expressed genes were mainly enriched in MAPK and NF-κB signaling pathways. Our findings suggest that CD1d down-regulation inhibited the proliferation and migration abilities of TPC-1 cells, increased cell apoptosis possibly via the MAPK/NF-κB signaling pathway.
Advances in synthetic lethality modalities for glioblastoma multiforme
Authors: Richard Seidu A. 
Published: June 2024

Abstract
Glioblastoma multiforme (GBM) is characterized by a high mortality rate, high resistance to cytotoxic chemotherapy, and radiotherapy due to its highly aggressive nature. The pathophysiology of GBM is characterized by multifarious genetic abrasions that deactivate tumor suppressor genes, induce transforming genes, and over-secretion of pro-survival genes, resulting in oncogene sustainability. Synthetic lethality is a destructive process in which the episode of a single genetic consequence is tolerable for cell survival, while co-episodes of multiple genetic consequences lead to cell death. This targeted drug approach, centered on the genetic concept of synthetic lethality, is often selective for DNA repair-deficient GBM cells with restricted toxicity to normal tissues. DNA repair pathways are key modalities in the generation, treatment, and drug resistance of cancers, as DNA damage plays a dual role as a creator of oncogenic mutations and a facilitator of cytotoxic genomic instability. Although several research advances have been made in synthetic lethality modalities for GBM therapy, no review article has summarized these therapeutic modalities. Thus, this review focuses on the innovative advances in synthetic lethality modalities for GBM therapy.
Natural convection and flow patterns of Cu–water nanofluids in hexagonal cavity: A novel thermal case study
Authors: Akram Mohammad , Benhanifia Kada , Brahim Mebarki , Rahmani Lakhdar , Ansari Abu Zaid , Eid Mohamed R. , Hussain Syed M. , Redouane Fares , Jamshed Wasim , Alraddadi Ibrahim 
Published: June 2024

Abstract
The purpose of the current research is to inspect the free convection of the nanofluid (Cu–water) within a hexagonal cavity containing a square obstacle with isothermal vertical walls at

T

h

{T}_{{\rm{h}}}

and

T

c

{T}_{{\rm{c}}}

, and insulated horizontal walls. The aim of this study is to analyze the interaction between the Rayleigh number (

10

3

<
Ra
<

10

5

{10}^{3}\lt {\rm{Ra}}\lt {10}^{5}

), obstacle’s position (top, bottom, and center), and volume fraction of the nanoparticles (

0
<
Ø
<
0.2

0\lt \O \lt 0.2

) on the thermal behavior within the enclosure. Simulations were performed using COMSOL Multiphysics software based on the finite element method. The obtained results were demonstrated using streamlines, isotherms, and average Nusselt numbers. It is concluded that the increase in the Rayleigh quantity

Ra

{\rm{Ra}}

and nanoparticle concentration

Ø

\O

increases the average Nusselt

N

u

av

{\rm{N}}{{\rm{u}}}_{{\rm{av}}}

, which expresses the rate of heat flow in the studied enclosure. Furthermore, the position of the inner obstacle in the middle of the cavity has a more significant thermal efficiency than the other cases.