bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acinic Cell Carcinoma of The Breast: A Population-Based Clinicopathologic Study
Authors: Skenderi Faruk , Babu Giridhara Rathnaiah , Glamoclija Una , Veledar Emir , Gatalica Zoran , Lamovec Janez , Vranic Semir 
Published: May 2024

Abstract

Purpose
Acinic cell carcinoma (ACC) of the breast is a very rare, primary salivary gland-type breast malignancy with ~ 100 reported cases in the literature. Limited information about the clinical features and outcomes of the patients with ACC is available.
Methods
We utilized the Surveillance, Epidemiology, and End Results (SEER) database to identify ACC cases diagnosed between 2000 and 2018. For comparison, we also examined a cohort of invasive breast carcinomas of no special type (NST).
Results
Thirty ACC cases were identified among over 248,000 invasive breast carcinoma NST cases in the SEER database. Most ACC cases affected the White population (87%) and individuals over 50 years old (70%). ACCs were predominantly grade 3 carcinomas (44%), diagnosed at an early stage (AJCC TNM stages I and II, 67%). Hormone receptor (HR) and HER2 status were available for 13 cases, revealing molecular heterogeneity: HR-/HER2- (four cases, 31%), HR-/HER2+ (two cases, 15%), HR+/HER2- (four cases, 31%), and HR+/HER2+ (three cases, 23%). Surgery was the primary treatment modality for 26 out of 30 (86.7%) ACC patients, with chemotherapy and radiotherapy used in 46.7% and 33% of cases, respectively. The median survival time for ACC patients was 19 months compared to 48 months for invasive breast carcinoma NST patients (p < 0.001). Year-wise survival rates for ACC patients showed a dramatic decrease in the number of at-risk patients over time, starting at 30 months and decreasing rapidly, compared to a slower decline in the invasive breast carcinoma NST group (p < 0.01). The log odds of death for ACC patients were significantly higher (by 4.5 times) than for invasive breast carcinoma NST patients (p < 0.01), indicating a substantially worse prognosis.
Conclusions
Acinic cell carcinoma of the breast is a very rare (0.01%) primary breast malignancy. Despite its early clinical presentation, ACC of the breast appears to have a more aggressive clinical course and poorer clinical outcomes compared with conventional breast cancer.
Comparative evaluation of four actual evapotranspiration models over different ecosystems and climate zones in China
Authors: Yuan Mengjia , Gan Guojing , Bu Jingyi , Su Yanxin , Ma Hongyu , Liu Xianghe , Gao Yanchun 
Published: May 2024

ABSTRACT

To better understand the discrepancies in evapotranspiration (ET) simulations between ET models, we intercompared four models in China: Priestley–Taylor Jet Propulsion Laboratory (PT-JPL), Penman–Montieth–Leuning Version 2 (PML-V2), Sigmoid Generalized Complementary Function (SGCF), Mapping Evapotranspiration at High Resolution with Internalized Calibration (METRIC). Data from 18 flux sites were used to evaluate the model performance at daytime (when incident shortwave radiation is greater than 20 W/m2) scales. To compare more fairly, we took the intersection of the outputs from four models for the analyses in the main text. All models yielded acceptable results, with PML-V2 or SGCF performing best at most sites. The average coefficient of determination and root mean square error among all sites of LE (latent heat of ET) were 0.72 and 51.71 W/m2 for PT-JPL, 0.80 and 46.65 W/m2 for PML-V2, 0.79 and 41.13 W/m2 for SGCF, 0.70 and 51.09 W/m2 for METRIC. PT-JPL and PML-V2 underestimated ET at most sites, whereas SGCF overestimated, potentially due to uncertainties in the vegetation indices and ET constraint parameters. Compared to measurements, PT-JPL underestimated the proportion of transpiration to evapotranspiration (0.81 versus 0.59), while PML-V2 overestimated (0.81 versus 0.90). Furthermore, all models performed best in the semi-arid zone dominated by grassland sites.
Today’s Mechanisms of Financing the 4th Energy-Transition
Authors: Altukhova E. V. 
Published: May 2024

Today global community focuses on stepping-up efforts aimed at cutting emissions of green-house gases to the atmosphere. It is connected with active realization of the 4th energy-transition strategy based on replacement of one power sources by others that are more efficient and ecologically clean. Current trends of sustainable development define priorities and new approaches to sources and forms of financing. Serious impact on selection of finance mechanisms is made by sectoral specific features demonstrating key lines of development. The article studies accessible efficient finance tools, which can provide a new format of interaction with regard to principles of power system functioning. As auxiliary resources fostering finance priority identification the author put forward ESG-accounting and ESG-ratings. European experience of using mechanisms of financing energy-effective projects can be interesting. The author formulated principles of the 4th energy-transition, showed key lines in the 4th energy-transition financing with regard to coordination of economic interests of process participants and highlighted the most important sources of financing. It is recommended to prioritize the development of technological competences oriented to home market.
The Role of Vitamins, Magnesium, and Trace Elements in COVID-19 Treatment and Post-COVID-19 Rehabilitation: An Updated Overview
Authors: Bjørklund Geir , Drapak Iryna , Zimenkovsky Borys , Shanaida Mariia , Kobylinska Lesya , Denefil Olha , Lysiuk Roman , Pokryshko Olena , Logoyda Liliya , Oliinyk Petro , Shanaida Volodymyr , Semenova Yuliya 
Published: May 2024

Abstract:
This review summarizes the scientific knowledge concerning the impact of vitamins,
magnesium, and trace elements on various mechanisms contributing to the possible
treatment and prevention of COVID-19, including its delayed consequences. A
search was conducted in various databases, including PubMed, Scopus, ClinicalTrials.-
gov, and Web of Science. Among the main mechanisms involved in the effects of the
studied micronutrients, immune-boosting, antioxidant and anti-inflammatory effects
were also highlighted. The analyzed clinical trials confirmed that supplementation with
higher daily doses of some micronutrients can reduce SARS-CoV-2 viral load and hospitalization
time. The potential role of most known vitamins in preventing, treating
COVID-19, and rehabilitating patients was considered. The most promising agents for
combating COVID-19 and its consequences might be the following vitamins: vitamin D,
ascorbic acid, polyunsaturated fatty acids (PUFAs), and some B complex vitamins. Inorganic
elements deserving attention include magnesium and trace elements, such as zinc,
selenium, copper, and iron. Some associations were found between micronutrient deficiencies
and COVID-19 severity in children, adults, and older people. Patients can obtain
the aforementioned micronutrients from natural food sources or as supplements/-
drugs in various dosage forms. The reviewed micronutrients might be considered adjunctive
treatment strategies for COVID-19 patients.
Cuproptosis-related Gene Signatures and Immunological Characterization in Sepsis-associated Acute Lung Injury
Authors: Zhu Mingyu , Tang Xiaokai , Xu Jingjing , Gong Yuanqi 
Published: May 2024

Background:
Sepsis is a frequent cause of acute lung injury (ALI), characterized by
immune dysregulation and a high mortality rate. The role of cuproptosis, a recently discovered
cell death mechanism, in sepsis-associated ALI is still unclear. The study aimed to investigate
the regulatory mechanisms and immune characteristics associated with cuproptosis in sepsisassociated
ALI, with implications for novel diagnostic and therapeutic approaches.

Methods:
Data from the GEO database was utilized to conduct a comprehensive analysis of the
cuproptosis-related genes (CRGs) in sepsis-associated ALI. Gene enrichment analysis, WGCNA,
CIBERSORT algorithm, and consensus clustering were employed to investigate the associations
between CRGs and immune cells. A predictive model for sepsis-associated ALI was developed
based on key CRGs, and its diagnostic accuracy was assessed. Finally, qPCR was employed
to validate alterations in the expression of CRGs in the sepsis-associated ALI cellular
model.

Results:
A total of 14 CRGs were identified in sepsis-associated ALI. Strong correlations between
the CRGs and immune cells were observed, and two different CRG subtypes were identified.
The expression of immune-related factors in both the CRG and gene clusters exhibited similarities,
suggesting a connection between the subgroups and immune cells. The prediction model
effectively forecasted the incidence of sepsis-associated ALI based on the expression of
CRGs. Finally, qPCR analysis confirmed that the expressions of CRGs in the sepsis-associated
ALI cell model closely matched those identified through bioinformatic analyses.

Conclusion:
The study comprehensively evaluated the complex relationship between cuproptosis
and sepsis-associated ALI. CRGs were found to be significantly associated with the occurrence,
immune characteristics, and biological processes of sepsis-associated ALI. These findings
provide valuable new insights into the mechanisms underlying sepsis-associated ALI.

result:
In total, 14 CRGs were identified in sepsis-associated ALI with healthy controls. Strong correlations between the CRGs and immune cells were observed and two different CRG subtypes were identified. The expression of immune-related factors in the CRG and gene clusters were similar, indicating an association between the subgroups and immune cell. The prediction model was effective in predicting the incidence of sepsis-associated ALI through the expression of CRGs. Real-time PCR analysis showed that the expression of CRGs in the sepsis-associated ALI cell model were similar to those from bioinformatic analyses.
Shuangdong Capsule Activates Insulin Signal Pathway to Improve Urinary Tract Infection in Diabetic Rats
Authors: Zhao Cong , Wang Bin , Mu Qi-xiang , Wu Jun , Cheng Zhen-han , Liu Qing , Li Hai-song , Wang Jisheng 
Published: May 2024

Background and Aim:
Diabetes and Urinary Tract Infections (UTIs) are both common
and serious health problems. Shuangdong capsule, a Chinese patent medicine, has been
used to treat these conditions. This study assesses its efficacy and mechanism in treating diabetes
combined with UTIs.

Methods:
We induced diabetes in rats using streptozotocin and UTIs with Escherichia coli, dividing
the rats into five groups: control, model, levofloxacin, Shuangdong capsule, and
levofloxacin + Shuangdong capsule. After two weeks, we measured blood glucose, insulin, infection
indicators, and bladder histology. We also detected the expression of insulin receptor
substrate 1 (IRS1)-phosphoinositide 3-kinase (PI3K)-protein kinase B (Akt)-C-X-C motif
chemokine ligand 2 (CXCL2) signaling pathway by Western Blot and the myeloperoxidase
(MPO) levels by Enzyme-Linked Immunosorbent Assay (ELISA). Additionally, we conducted
a Mendelian randomization study using genetic variants of the insulin receptor to assess its
causal effect on UTI risk.

Results:
Shuangdong capsule improved bladder pathology and infection indicators, similar to
levofloxacin. It did not affect blood glucose or insulin levels. Moreover, it reversed the suppression
of the IRS1-PI3K-Akt-CXCL2 pathway and MPO levels caused by UTI in diabetic rats.
The Mendelian randomization study showed that increased insulin receptor expression reduced
UTI risk, which was consistent with the results of the animal experiments.

Conclusion:
The Shuangdong capsule was effective in treating diabetes with UTIs. It may function
by activating the IRS1-PI3K-Akt signaling pathway, thereby increasing CXCL2 and MPO
levels, enhancing innate immunity, and promoting bacterial clearance. The Mendelian randomization
study provided further evidence supporting the causal role of the insulin receptor in UTI
prevention.

other:
No.
Lignans: Advances in Biosynthesis, Bioavailability, and Pharmacological Activity
Authors: Singh Sonia , Sharma Shiwangi 
Published: May 2024

Abstract:
Lignans, a group of naturally occurring compounds abundant in various plant-based
foods, are becoming increasingly popular due to their potential health benefits. The literature
suggests that these bioactive substances can reduce the risk of certain types of cancer, such as
postmenopausal colon and breast cancer. Moreover, the significance of lignans for improving
cardiovascular health has been recognized, as studies have revealed a potential correlation between
the intake of lignans and a decreased risk of cardiovascular disease. These complex molecules
possess diverse bioactive capabilities, rendering them potential alternatives for preventing
chronic diseases. Further research is needed to examine the mechanisms responsible for
their beneficial outcomes. Recent research has emphasized the pharmacological properties of
lignans as effective substances for human health. Incorporating foods rich in lignans into the
diet may be a practical approach to enhancing protection against life-threatening ailments, such
as cardiovascular diseases and malignancies.
From Synthesis to Solutions: Hydrogels' Impact on the Biomedical
Landscape
Authors: Mittal Ravi K. , Krishna Gaurav , Mishra Raghav , Uddin Rehan , Sharma Vikram 
Published: May 2024

Abstract:
This review aims to examine the hydrogel structure concisely, approaches to hydrogel
synthesis, and the most recent progressions in hydrogel technology along with its multifaceted
applications within the domain of biomedicine, emphasizing its capacity to transform the delivery
of drugs, tissue engineering, and diagnostics.
This review employs an organized search of the literature to gather and evaluate state-of-the-art
examines on hydrogel uses for biomedicine, synthesizing significant developments and breakthroughs
to provide a holistic comprehension of their developing role and possible impact.
The review's findings emphasize the revolutionary potential of recent advances in hydrogel uses
within biomedicine, which includes improved drug delivery, cutting-edge tissue engineering, and
recognized diagnostics.
In summary, this scholarly article explores the intricacies of hydrogel structure, methodologies
for hydrogel synthesis, and notable breakthroughs in the biomedical utilization of hydrogels.
Given the extraordinary potential of hydrogels to transform diagnostic and therapeutic methodologies,
this article emphasizes the growing significance of hydrogels in biomedicine and the
critical need for further investigation into this subject matter. Consequently, hydrogels can pave
the way for enhanced healthcare standards.
LncRNA TUG1 and its Molecular Mechanisms in Human Cancer
Authors: Wu Shijie , Wu Kun , Yang Yuqing , Ou Zhiwen , Lei Xiaoyong , Yang Xiaoyan 
Published: May 2024

Abstract:
As lncRNAs have increasingly been investigated, they are no longer simply
defined as RNAs with no transcription capability. Studies have identified significant
associations between the abnormal expression of lncRNAs and human diseases,
particularly the mechanisms by which lncRNAs play a part in cancers, which are of
considerable attention to researchers. As a result of the complex spatial structure, the
mechanisms of interaction of lncRNAs in cancer cells are also complicated and
diversified. Among a series of lncRNAs, TUG1, which is now considered to be a very
high-value lncRNA, has recently been identified to express abnormally in some
malignancies, leading to different alterations in cancer cells proliferation, migration,
invasion, apoptosis, and drug resistance, and hence promoting or inhibiting cancer
progression. Current studies have implicitly indicated that TUG1 can be used as a
therapeutic target for human cancers. However, the biological functions of TUG1 have
been studied for a short period of time, and the complete molecular mechanism still
needs to be clarified. Accordingly, this review focuses on the principal molecular
mechanisms of TUG1 in human cancers and the specific mechanisms of action in
different cancer development processes based on existing studies.
Factors Impacting ART Adherence among HIV-Positive Older Adolescents and Younger Adults in Namibia: A Qualitative Analysis
Authors: Kamangu Jacques Wa Nsenda , Mboweni Sheillah Hlamalani 
Published: May 2024

Background
Namibia, like many sub-Saharan African countries, faces the challenges of Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS) affecting diverse age groups. However, the demographic group of older adolescents and younger adults, specifically those aged 15-24, faces distinct challenges in terms of psychological, sociocultural, and healthcare-related factors that impact their adherence to Antiretroviral Treatment (ART). It is important to conduct further research to investigate these specific challenges and address them effectively.

Aim
This paper aimed to investigate factors impacting adherence to ART medication among Older Adolescents (OA) and Younger Adults Living with HIV (YALHIV) in the seven high-burden regions in Namibia.

Objective
The objective of this study was to explore and describe the factors that influence adherence to ART medication among older adolescents and younger adults living with HIV to provide valuable insights to inform the development of evidence-based HIV programs that can effectively address the adherence challenges in this particular population.

Methods
A qualitative descriptive phenomenology research design was followed, utilising an in-depth interview to capture the experiences of older adolescents and younger adults living with HIV. Participants were recruited from healthcare facilities across Namibia, ensuring a diverse sample in terms of gender, socio-economic status, and urban-rural representation. A purposive sampling technique was employed to select 29 participants who were willing to take part in the study and data saturation was achieved with this sample size. The interviews were telephonically recorded with the permission of the participants. The researcher used Colaizzi's six steps for phenomenological study to analyze the data.

Results

The study reveals four main themes that contribute to adherence issues in OALHIV and YALHIV and include patients-related factors, family-related factors, facility and healthcare providers-related factors, and community and socio-cultural characteristics-related factors.

Conclusion
The study sheds light on factors affecting adherence to ART among OALHIV and YALHIV. It emphasizes the necessity of comprehensive interventions addressing personal, sociocultural, economic, and healthcare challenges for their well-being. Future research and policies should focus on tailored interventions based on these diverse findings.
Recent Advances and Clinical Approach to Cancer Treatment with Nanotechnology
Derived Biomolecule
Authors: Singh Atul Pratap , Akhtar Wasim , Alam Saif , Naziya  
Published: May 2024

Abstract::
Cancer nanomedicine has the potential to take advantage of the multifunctionality and diverse
biological activity of nanostructures based on biomolecules. Novel drug delivery vehicles can
be designed by programming the supramolecular features of biomolecules to achieve multiple therapeutic
goals at once, including efficient in vivo transport and targeted drug administration. Proteins,
peptides, nucleic acids, and polysaccharides can all be engineered into multipurpose nanomedicines.
Even while numerous cancer medications reduce mortality, they are still insufficient. Early cancer
cell detection and high-specificity therapeutic administration optimise treatment and prevent toxicity.
Nanotechnology is improving cancer diagnosis and treatment due to increased systemic toxicity
and refractoriness with current methods. Nanotechnology-based immunotherapeutic drugs have reduced
cancer cell invasiveness while protecting healthy cells in several cancer types. Carbon nanotubes,
polymeric micelles, and liposomes improve cancer medication pharmacokinetics and pharmacodynamics.
Nanomedicines' use in patient care and promising nanotechnology-based cancer interventions
have been covered in this article. Nanomaterials used in treating cancer have been discussed.
Additionally, nanomaterial obstacles that hinder their applicability and clinical translation in
certain cancer types are addressed.
Patent Analysis of Soft Pneumatic Actuators: A Systematic Literature
Review
Authors: Mastrisiswadi Hasan , Sari Wangi Pandan , Tontowi Alva Edy , Herianto  
Published: May 2024

Background::
The soft pneumatic actuator is a technology in the robotics field driven by
pneumatic power. Further, the problems in complicated fabrication processes can now be overcome
with new technologies, such as additive manufacturing. Thus, the number of patent documents will
also continue to increase. For this reason, a patent analysis is needed to help researchers map the direction
of the research to be carried out.

Objective::
By analyzing existing patents, unnecessary investment in technology can be avoided as
early as possible. Thus, this article aimed to find updates and gaps in existing patents.

Method::
The patent analysis in this study used the systematic literature review method, which started
with identifying, screening, and determining the patents being reviewed.

Result::
In the early stages, 114 patents were obtained, and after screening, 18 patents related to the
soft pneumatic actuator were obtained, divided into six families. Patents related to the existing soft
pneumatic actuator are more directed to robotics and wearable devices. Hence, the current patent
gap is still very wide open regarding fabrication, geometric shapes, and its application in other
fields.

Conclusión::
Research gaps were obtained related to fabrication technology, geometric shapes, and
applications in fields other than robotics and wearable devices that are still very wide open for development
and patent registration to advanced technology.
A Calculation Method for Static Hysteresis Loop and its Applications
Authors: Fu Yu , Miao Yu , Li Xinhao , Zhao Xiaojun , Qian Ziyi , Wang Haoming 
Published: May 2024

Background:
Due to experimental equipment limitations, it is usually difficult to
measure the quasi-static hysteresis loop at extremely low frequencies, which inevitably introduces
errors in the static hysteresis model.

Objective:
This study aims to propose a method for calculating the static hysteresis loops of grainoriented silicon steel sheets so as to improve the accuracy of the static and dynamic hysteresis
model.

Methods:
The parameters n0 and V0 in the magnetic field strength expression of the excess loss are
determined by the measured losses within the range of 0-100Hz. Subsequently, the dynamic components in the quasi-static hysteresis loops are eliminated. Furthermore, a dynamic hysteresis
model is established based on the loss and field separation theory, which incorporates the inverse
Preisach model.

Results:
The dynamic hysteresis loops of the grain-oriented silicon steel sheets are measured in
the range of 8-250Hz and compared with the results of both the improved model and the original
model.

Conclusion:
Experimental results demonstrate the effectiveness and accuracy of the improved
model. The proposed method for calculating static hysteresis loops has universal applicability and
is meaningful for accurate simulation and prediction of magnetic properties in soft magnetic materials.