bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pathogenesis of reduced or increased bladder sensation
Authors: Tsunoyama Kuniko , Sakakibara Ryuji , Yamaguchi Chiharu , Uchiyama Tomoyuki , Yamamoto Tatsuya , Yamanishi Tomonori , Takahashi Osamu , Sugiyama Megumi , Kishi Masahiko , Ogawa Emina 
Published: February 2011

AbstractObjectivePathogenesis of reduced or increased bladder sensation is not well known. Hence, we systematically investigated the frequency of reduced or increased bladder sensation in neurologic/mental diseases.MethodsWe analyzed 911 patients who were referred from within our hospital. Data registries included a diagnosis, a lower urinary tract symptom questionnaire, a urodynamic study, and neurological examinations. Reduced bladder sensation is defined as bladder volume at the first sensation >300 ml. Increased bladder sensation is defined as bladder volume at the first sensation <100 ml. These patients were stratified into those with and without DO.ResultsNeuropathies are the most common cause of reduced bladder sensation (33.3–43.8% in diabetic neuropathy, etc.). Myelopathies are the second most common cause (17.4–25.0% in multiple sclerosis, etc.). Less common is brain diseases (9.6% in multiple system atrophy, etc.). In contrast, myelopathies are the most common cause of increased bladder sensation without DO (25.0–40.0% in spinal forms of systemic lupus erythematosus, Sjogren's syndrome, etc.). Neuropathies are the second most common (17.3–22.2% in post‐pelvic organ surgery, diabetic neuropathy, etc.). Less common is brain/mental diseases (20.0% in psychogenic bladder dysfunction, 8.1% in Parkinson's disease, etc.).ConclusionThe present study revealed that neuropathies are the most common cause of reduced bladder sensation in neurologic/mental diseases. Increased bladder sensation without DO occurs mainly in peripheral and central sensory pathway lesions, as well as in basal ganglia lesions and psychogenic bladder dysfunction. Reduced and increased bladder sensation should be a major treatment target for maximizing patients' quality of life. Neurourol. Urodynam. 30:339–343, 2011. © 2011 Wiley‐Liss, Inc.
Italian version of qualiveen‐30: Cultural adaptation of a neurogenic urinary disorder‐specific instrument
Authors: Bonniaud Véronique , Bryant Dianne , Pilati Claudio , Menarini Mauro , Lamartina Marcello , Guyatt Gordon , Del Popolo Giulio 
Published: February 2011

AbstractPurposeQualiveen‐30 is a neurological urinary disorder (UD)‐specific health‐related quality of life (HRQL) instrument, recommended in the European Association of Urology guideline 2008. The objective is to complete the cultural adaptation of Qualiveen‐30 into Italian.Materials and MethodsOne hundred and twenty eight Italian‐speaking spinal cord injury (SCI) patients completed Qualiveen‐30 and the SF‐12 physical and mental component (PC and MC) at enrolment and 4 weeks later. At follow‐up, patients also made global ratings of change (GRC) in urinary HRQL (GRC).ResultsQualiveen‐30 proved reliable (intraclass correlation coefficients of four domains: 0.77–0.90). Correlations with SF‐12 and GRC were generally consistent with our a priori predictions. Qualiveen‐30 domains showed weak‐to‐moderate cross‐sectional correlations with SF‐12 scores (0.31–0.45 PC and 0.28–0.45 MC). Correlations between changes in Qualiveen‐30 scores and in SF‐12‐PC scores were weak or absent. Correlations between changes in Qualiveen‐30 scores and in SF‐12‐MC scores were weak to moderate (0.25–0.38). Relationships between change in Qualiveen‐30 and GRC were moderate to strong (0.48–0.56). The responsiveness was excellent, similar to the original form (SMR: 1.76–2.31). Minimally important difference values in the four domains varied from 0.34 to 0.47.ConclusionsItalian Qualiveen‐30 is a reliable, valid, and responsive measure of UD‐related HRQL in SPI patients. Investigators can be confident of the Qualiveen‐30 questionnaire's ability in distinguishing between patients in a cross‐sectional survey, as well as in measuring within‐subject changes over time in clinical trials in French, English, and Italian. Neurourol. Urodynam. 30:354–359, 2011. © 2011 Wiley‐Liss, Inc.
Reducing nocturia in the elderly: A randomized placebo‐controlled trial of staggered furosemide and desmopressin
Authors: Fu Fei‐Guo , Lavery Hugh J. , Wu Deng‐Long 
Published: February 2011

AbstractAimsThe purpose of this study was to investigate efficacy, safety, and impact on quality of sleep of staggered furosemide and desmopressin in the treatment of nocturia in the elderly.MethodsPatients aged >60 years with nocturia at least two voids per night were screened for enrollment into the study. A 3‐week dose‐titration phase established the optimum desmopressin dose (0.1, 0.2, or 0.4 mg). After a 1‐week “washout” period, patients who showed sufficient response during the dose‐titration period were randomized to receive staggered furosemide and the optimal dose of desmopressin or placebo in a double‐blind design for 3 weeks. Voiding diaries were assessed before and after the treatment.ResultsIn all, 82 patients were randomized to either staggered furosemide and desmopressin (n = 41) or placebo (n = 41). In the study group, most patients reported a good response with both reduced nocturnal voids (3.5 vs. 2.0, P < 0.01) and urine volume (919.6 ml vs. 584.2 ml, P < 0.01). The mean duration of the first sleep period was improved by 70 min (133.6 vs. 203.2, P < 0.01). Compared to placebo, staggered furosemide and desmopressin resulted in a significant reduction in the mean number of nocturnal voids (43% vs. 9%; P < 0.01), nocturnal urine volume (37% vs. 5%; P < 0.01), and increase in the mean duration of the first sleep period (52% vs. 19%, P < 0.01). Adverse events were mild.ConclusionsStaggered furosemide and desmopressin provide an effective and well‐tolerated treatment for nocturia in the elderly. Neurourol. Urodynam. 30:312–316, 2011. © 2011 Wiley‐Liss, Inc.
Ultrasound estimated bladder weight in men attending the uroflowmetry clinic
Authors: Bright Elizabeth , Pearcy Richard , Abrams Paul 
Published: February 2011

AbstractAimsTo determine if measurements of ultrasound estimated bladder weight (UEBW) provide an additional diagnostic tool when assessing men with lower urinary tract symptoms (LUTS) in the uroflowmetry clinic.MethodsOne hundred men with LUTS attending the uroflowmetry clinic underwent transabdominal ultrasound measurement of bladder weight, using the BVM 9500 bladder scanner (Verathon Medical, Bothell, WA). These data were explored for any correlation between measurements of maximum flow rate (Qmax) with UEBW, age, height, weight, body mass index (BMI), ICIQ M‐LUTS score, M‐LUTS voiding score, M‐LUTS incontinence score, IPSS, IPSS quality of life score, voided volume, and post‐void residual urine. Based on previously reported probabilities of bladder outlet obstruction (BOO), patients were grouped for analysis (Group 1 = Qmax <10, Group 2 = Qmax 10–15, Group 3 = Qmax >15). A one‐way ANOVA was undertaken to assess any difference in mean UEBW between the three groups.ResultsStatistically significant negative correlations between Qmax and age (r = −0.308, P = 0.002), M‐LUTS voiding score (r = −0.298, P = 0.003), IPSS (r = −0.295, P = 0.003), and post‐void residual (r = −0.213, P = 0.033) were observed. A statistically significant positive correlation between Qmax and voided volume (r = 0.503, P < 0.01) was observed. No association between Qmax and UEBW was observed (r = 0.12, P = 0.243). Mean UEBW for the three groups was remarkably similar. One‐way ANOVA identified there was no statistically significant effect of UEBW on Qmax F(2, 97) = 0.175, P = 0.840.ConclusionMean UEBW did not differ significantly between the three Qmax groups. Further work is required to investigate the relationship of Qmax and UEBW in men with urodynamic confirmation of either BOO or detrusor underactivity. Neurourol. Urodynam. 30:583–586, 2011. © 2011 Wiley‐Liss, Inc.
The effect of biological and synthetic meshes on vaginal smooth muscle cell proliferation
Authors: Gualtieri Marc , Zhang Yanping , Candiotti Keith , Yavagal Sujata , Medina Carlos A. , Takacs Peter 
Published: February 2011

AbstractAimsTo compare the effects of polypropylene mesh or porcine dermal acellular collagen matrix mesh with and without estradiol supplementation on vaginal smooth muscle cells (VaSMC) proliferation.ResultsUnder in vitro culture conditions, VaSMC proliferation was significantly higher in the porcine dermal acellular collagen matrix mesh exposed cells compared to the type I polypropylene mesh exposed cells (relative cell number, mean ± SD, 0.27 ± 0.03 vs. 0.21 ± 0.01, P = 0.03). Under estradiol supplementation cell proliferation in the porcine mesh exposed cells remained significantly higher compared to the polypropylene mesh exposed cells (relative cell number, mean ± SD, 0.27 ± 0.04 vs. 0.15 ± 0.03, P < 0.01).ConclusionThe decreased rate of erosion found with the utilization of biological absorbable mesh in vaginal reconstructive surgery may partially be explained by the significantly increased VaSMC proliferation with porcine dermal acellular collagen mesh compared to polypropylene mesh. Neurourol. Urodynam. 30:435–437, 2011. © 2011 Wiley‐Liss, Inc.
Dimensioning internet protocol television video on demand services
Authors: Pandey Suman , Won Young J. , Hong James W. , Strassner John 
Published: February 2011

SUMMARYThe Internet Protocol Television (IPTV) subscription rate has increased steadily since the introduction of IPTV Video on Demand (VoD) services. We have developed a model to determine the optimum deployment strategy for delivering IPTV VoD network services from the IPTV service providers' perspective. The analysis technique in this paper helps us determine how to support a particular IPTV VoD deployment having a given number of customers that each must receive a contracted Quality of Experience (QoE). The main QoE measures considered are server waiting time, one‐way minimum delay and access network bandwidth consumption. All these models are made considering heterogeneous network conditions. The QoE models will help service providers make network deployment decisions including the number of servers, distance of servers from a community and desirable access network bandwidth capacity. Copyright © 2011 John Wiley & Sons, Ltd.
Preparation of microencapsulated ammonium polyphosphate with montmorillonite‐melamine formaldehyde resin and its flame retardancy in EVM
Authors: Zhang Yingjun , Lu Yanbing , Guo Fei , Peng Chang , Li Mingming , Xu Weijian 
Published: February 2011

AbstractMicroencapsulated ammonium polyphosphate (MMT‐MF‐APP) with a montmorillonite‐melamine formaldehyde resin coating layer was successfully prepared by in situ polymerization. The product was characterized by Fourier‐transform infrared, X‐ray photoelectron spectroscopy, and scanning electron microscopy. Water absorption analysis showed that the microencapsulation of APP with the MMT‐MF resin leads to a decrease in the particle's water solubility. The microcapsules also exhibited better mechanical properties and higher flame retardancy in the ethylene–vinyl acetate copolymer with high vinyl acetate content (EVM) rubber compared with the common ammonium polyphosphate. Moreover, thermogravimetric analysis results showed that the EVM composites with MMT‐MF‐APP and dipentaerythritol (DPER) as flame retardants possess higher thermal stability than those with common APP and DPER as flame retardants. Copyright © 2011 John Wiley & Sons, Ltd.
Electromagnetic interference and electrical conductivity behavior of carbon/polycyanate composite with nickel nanostrands™ under fatigue
Authors: Mall S. , Rodriguez J. , Alexander M.D. 
Published: February 2011

AbstractA conductive nanocomposite containing nickel nanostrands™ in carbon fiber‐reinforced polymeric composite (M55 carbon fibers in toughened polycyanate resin matrix, RS‐3) was investigated for electromagnetic interference (EMI) and electrostatic discharge (ESD) shielding effectiveness when subjected to the tension–tension fatigue load. These were measured in terms of dB attenuation and sheet resistance, respectively. Four configurations, one without nickel nanostrands and other three with different locations of nickel nanostrands layers, were investigated. The locations were outside surfaces, dispersed throughout the laminate thickness or the midplane. Fatigue strength was not affected by the addition of nickel nanostrands at any location. The addition of nickel nanostrands enhanced, in general, the EMI and ESD shielding effectiveness of the baseline polymeric composite with carbon fibers. However, the exterior location provided the maximum enhancement of EMI and ESD effectiveness. Furthermore, both EMI and ESD shielding effectiveness were practically constant under tension–tension fatigue loading condition up to 2 million cycles. This was because the nickel nanostrands were intact under fatigue loading condition. POLYM. COMPOS., 2011. Published 2011 Society of Plastics Engineers
Application of chitosan emulsion as a coating on Kraft paper
Authors: Reis Arlete B , Yoshida Cristiana MP , Reis Ana Paula C , Franco Telma T 
Published: February 2011

AbstractKraft paper was coated with chitosan emulsion film. The novelty of this paper is the formation of a packaging bilayer system in only one drying step, which combines a biodegradable polymer emulsion (chitosan and palmitic acid) with Kraft paper. This system is described in detail and characterized for barrier properties (water vapor permeability rate (WVPR), air permeability and water absorption capacity (Cobb test)), mechanical properties (tensile properties, Taber stiffness and tear strength) and structural properties. The application of chitosan coating (3.5 g m−2, wet basis) on Kraft paper sheets provides a significantly lower WVPR (by ca 43%) and water absorption capacity (by ca 35%) as compared to uncoated Kraft paper. The incorporation of palmitic acid into the chitosan film solutions at 1.8 g m−2 improves the properties of Kraft paper even more by further reducing the WVPR and water absorption capacity by 51 and 41%, respectively. The air resistance of the coated Kraft systems is lower by 8‐ and 11‐fold compared to uncoated Kraft paper, which could be associated with the chitosan film acting as a gas barrier and as a coating agent that fills the pores between cellulose fibers. Copyright © 2011 Society of Chemical Industry
Structure and function of chitinases from glycoside hydrolase family 19
Authors: Ubhayasekera Wimal 
Published: February 2011

AbstractGlycoside hydrolase family 19 chitinases are found in plants, bacteria and viruses, playing various roles. Plant chitinases are important for defence and development, whereas bacterial examples are useful for nutrition. The available structural studies show that family 19 enzymes are highly α‐helical bi‐lobed structures with a wide cleft lined by conserved residues important for catalysis and substrate binding. Class I and II plant chitinases possess loops which are absent in class IV and/or bacterial chitinases. One of the loops seems to retain a significant function. These inverting endochitinases demonstrate a possible opening–closing mechanism of the catalytic cleft during chitin hydrolysis due to loop movements. However, complex structures with inhibitors and/or substrate/product analogues are required for a deeper understanding of these enzymes. Copyright © 2011 Society of Chemical Industry
Supramolecular columnar nanostructures from self‐organization of coil–rod–coil molecules incorporating an anthracene unit
Authors: Zhong Ke‐li , Man Zhijin , Huang Zhegang , Chen Tie , Yin Bingzhu , Yi Jin Long 
Published: February 2011

AbstractWe report the synthesis and self‐assembly behavior of coil–rod–coil molecules. These molecules each consist of two biphenyl groups and an anthracene unit connected with ethynyl bonds at the 1,8‐position of anthracene as a rod segment, with methoxy or octyl groups at the 10‐position of anthracene, and poly(ethylene oxide) with degrees of polymerization of 12 and 17 linked to the biphenyls as coil segments. Structural investigation of these molecules by means of differential scanning calorimetry, polarized optical microscopy and X‐ray diffraction in the bulk state reveals that these molecules self‐assemble into lamellar structures in the solid state, while, in the liquid‐crystalline phase, they self‐organize into various columnar assemblies depending on the volume fraction of coil segments. Copyright © 2011 Society of Chemical Industry
Solid‐Phase Cross‐Linking (SPCL): A new tool for protein structure studies
Authors: Paramelle David , Enjalbal Christine , Amblard Muriel , Forest Eric , Heymann Michaël , Cantel Sonia , Geourjon Christophe , Martinez Jean , Subra Gilles 
Published: February 2011

AbstractA wide range of chemical reagents are available to study the protein–protein interactions or protein structures. After reaction with such chemicals, covalently modified proteins are digested, resulting in shorter peptides that are analyzed by mass spectrometry (MS). Used especially when NMR of X‐ray data are lacking, this methodology requires the identification of modified species carrying relevant information, among the unmodified peptides. To overcome the drawbacks of existing methods, we propose a more direct strategy relying on the synthesis of solid‐supported cleavable monofunctional reagents and cross‐linkers that react with proteins and that selectively release, after protein digestion and washings, the modified peptide fragments ready for MS analysis. Using this Solid‐Phase Cross‐Linking (SPCL) strategy, only modified sequences are analyzed and consistent data can be easily obtained since the signals of interest are not masked or suppressed by over‐represented unmodified materials.
Proteomic identification of radiation response markers in mouse intestine and brain
Authors: Lim Young‐Bin , Pyun Bo‐Jeong , Lee Hae‐June , Jeon Sang‐Rok , Jin Yeung Bae , Lee Yun‐Sil 
Published: February 2011

AbstractIncreasing efforts are being made to develop more sensitive and faster molecular methodologies at the genomic and proteomic levels for the identification of protein markers after exposure to ionizing radiation (IR). However, few specific protein markers, especially organ‐specific markers, have been identified. In this study, we analyzed altered protein expressions in various tissues, namely, brain, lung, spleen, and intestine, from 1 Gy‐irradiated mice by employing 2‐DE analysis. MALDI‐TOF MS and peptide mapping identified 25 proteins that showed greater than twofold expressional changes. In order to confirm significant differences between control and IR‐treated samples, ten identified proteins with available commercial antibodies were selected for immunoblotting. Of these, only five showed protein expression patterns that were similar to 2‐DE data. These were heat shock protein 5 (HSP 5), HSP 90 kDa β, HSP 1, transaldolase 1 (TA1), and phosphoglycerate kinase 1 (PGK1). In particular, PGK1 was specifically upregulated in mouse intestine, and TA1 was specifically downregulated in brain by irradiation. TA1 expression was unaltered in other tissues. Based on these data, we suggest that TA1 and PGK1 can be considered as candidate tissue‐specific protein markers of IR exposure.
Redox‐regulatory mechanisms induced by oxidative stress in Brassica juncea roots monitored by 2‐DE proteomics
Authors: Alvarez Sophie , Galant Ashley , Jez Joseph M. , Hicks Leslie M. 
Published: February 2011

AbstractROS, including hydrogen peroxide (H2O2), can serve as cellular signaling molecules following oxidative stress. Analysis of the redox state of proteins in Brassica juncea roots by 2‐DE proteomics following treatment with either exogenous H2O2 or buthionine sulfoximine, which depletes glutathione to cause accumulation of endogenous H2O2, led to the identification of different sets of proteins. These data suggest that exogenous and endogenous oxidative stresses trigger specialized responses.
Compartmentalized linkage of genes encoding interacting protein pairs
Authors: Nirantar Saurabh R. , Ghadessy Farid J. 
Published: February 2011

AbstractEmulsion technology has been successfully applied to the fields of next‐generation high‐throughput sequencing, protein engineering and clinical diagnostics. Here, we extend its scope to proteomics research by developing and characterizing a method, termed iCLIP (in vitro compartmentalized linkage of interacting partners), which enables genes encoding interacting protein pairs to be linked in a single segment of DNA. This will facilitate archiving of the interactomes from library versus library two‐hybrid screens as libraries of linked DNAs. We further demonstrate the ability to interrogate a model yeast two‐hybrid iCLIP library for interactants by “PCR‐pulldown,” using a primer specific to a gene of interest along with a universal primer. iCLIP libraries may also be subjected to high‐throughput sequencing to generate interactome information. The applicability of the technique is also demonstrated in the related context of the bacterial two‐hybrid system.
Handbook of Epilepsy Treatment
Authors: Shorvon Simon 
Published: February 2011

AbstractBeing invited to write an editorial about a book1 I myself authored, is a rather strange experience. I wondered how best to approach the task, and decided, in the 500 or so allotted words, to address what is perhaps the most intriguing question for any author now as we enter the second decade of the age of the internet, namely: ‘Are medical books still required?’. Copyright © 2011 Wiley Interface Ltd
GP consortia and community mental health services – a new model
Authors: Hashmi Sammad , Mortimer Ann 
Published: February 2011

AbstractThe 2010 Department of Health White Paper Equity and Excellence: Liberating the NHS1 outlines plans to place commissioning in the hands of new GP consortia, thus breaking down the primary/secondary care divide. In this article, Dr Hashmi and Professor Mortimer discuss what they think the changes will mean for community mental health services. Copyright © 2011 Wiley Interface Ltd
Electroconvulsive therapy and its place in the management of depression
Authors: Singhal Ankush 
Published: February 2011

AbstractElectroconvulsive therapy (ECT) is a psychiatric treatment with a controversial history. Advances in technology have led to a safer therapy, making it once again an option in very specific circumstances. Here, Dr Singhal discusses its current role in the management of depression. Copyright © 2011 Wiley Interface Ltd
Appropriateness of GP referrals of patients with anxiety and depression
Authors: Belgamwar Madhvi , Bates Catherine , Goes Celina , Taylor Nick 
Published: February 2011

AbstractIn its guidelines on anxiety and depression, NICE recommends a stepped care approach to patient management. In this study, the authors assessed the appropriateness of GP referrals to their community general adult mental health services of patients with anxiety and depression, according to the NICE guidelines. Copyright © 2011 Wiley Interface Ltd