bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrative geospatial approaches for the comprehensive monitoring and assessment of land management sustainability: Rationale, Potentials, and Characteristics
Authors: Buenemann M. , Martius C. , Jones J. W. , Herrmann S. M. , Klein D. , Mulligan M. , Reed M. S. , Winslow M. , Washington‐Allen R. A. , Lal R. , Ojima D. 
Published: December 2010

AbstractSustainable dryland management seeks to improve the conditions of people and ecosystems affected by degradation, but it is often unclear which land management strategies work, which ones do not and why. Monitoring and assessment (M&A) can support decision‐making by providing this information. As implied by the 10‐year Strategy of the United Nations Convention to Combat Desertification (UNCCD), however, M&A efforts have thus far been insufficient or inadequate. We argue that integrative geospatial approaches should be implemented to enhance dryland management decision‐making. By assimilating and linking human and environmental data, qualitative and quantitative data, as well as field and remotely sensed data in a spatially explicit framework, such approaches facilitate assessments of both the complexities and place‐specificities inherent to sustainability. In addition, they help represent different stakeholder perspectives, promote communication among scientists from diverse backgrounds as well as between scientific and local experts, facilitate inter‐institutional knowledge sharing, and create synergy between the UNCCD and other Conventions. Due to these benefits as well as the rapid evolution and increasing availability and affordability of geospatial data and technologies in all countries, it is appropriate to begin capitalizing more fully on them now for the M&A of land management sustainability. In order for integrative geospatial approaches to become more central to M&A efforts, however, capacities and infrastructure must be improved and standards and protocols developed for the collection, analysis, and modeling of data, for the evaluation of outputs, and for the reporting of results. Copyright © 2010 John Wiley & Sons, Ltd.
Essential spectra of singular matrix differential operators of mixed order in the limit circle case
Authors: Qi Jiangang , Chen Shaozhu 
Published: December 2010

AbstractThe present paper is concerned with the essential spectrum of the singular matrix differential operator of mixed order

over the interval (a, b), where D = d/dt. It is shown that if the coefficients are locally integrable functions and T is in the limit circle case, then the essential spectrum of T is given by the essential range of ${{p(t)d(t)-\vert h(t)\vert^2}\over{p(t)}} $\end{document}. The main idea is to transform the original spectral problem into a spectral problem of a singular Hamiltonian differential operator so that the classical Titchmarsh‐Weyl theory can apply. The approach used here can be applied to many other cases. © 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
Relative bioavailability of coumarin from cinnamon and cinnamon‐containing foods compared to isolated coumarin: A four‐way crossover study in human volunteers
Authors: Abraham Klaus , Pfister Michael , Wöhrlin Friederike , Lampen Alfonso 
Published: December 2010

AbstractScope: Cassia cinnamon contains high levels (up to 1 %) of coumarin. Heavy consumption of this spice may result in a dose exceeding the tolerable daily intake (TDI). In this context, the question was raised whether coumarin in the plant matrix of cinnamon has the same bioavailability as isolated coumarin.Methods and results: A four‐way crossover study was performed, in which the same dose of 12 mg coumarin was administered in different formulations to 24 healthy volunteers. The relative extent of absorption measured as urinary excretion of the main metabolite 7‐hydroxycoumarin (7OHC) was found to be 62.8% for isolated coumarin in a capsule (reference), 56.0% for cinnamon in capsules, 66.1% for cinnamon tea, and 54.7% for cinnamon in rice pudding (means, n=23, observation period 8 hours). Additionally, 7OHC plasma levels were measured for 105 minutes after administration and revealed a fast absorption of coumarin from cinnamon tea leading to the highest peak concentrations.Conclusion: The relative extent of absorption of coumarin from powder of cassia cinnamon is only slightly lower than that of isolated coumarin. Therefore, the TDI of coumarin can be used for risk assessment of coumarin exposure from cinnamon‐containing meals.
Interactive effects of corticosteroid and mechanical ventilation on diaphragm muscle function
Authors: Sassoon Catherine S.H. , Zhu Ercheng , Fang Liwei , Ramar Kannan , Jiao Guang‐Yu , Caiozzo Vincent J. 
Published: December 2010

AbstractInformation on the interactive effects of methylprednisolone, controlled mechanical ventilation (CMV), and assisted mechanical ventilation (AMV) on diaphragm function is sparse. Sedated rabbits received 2 days of CMV, AMV, and spontaneous breathing (SB), with either methylprednisolone (MP; 60 mg/kg/day intravenously) or saline. There was also a control group. In vitro diaphragm force, myofibril ultrastructure, αII‐spectrin proteins, insulin‐like growth factor‐1 (IGF‐1), and muscle atrophy F‐box (MAF‐box) mRNA were measured. Maximal tetanic tension (Po) decreased significantly with CMV. Combined MP plus CMV did not decrease Po further. With AMV, Po was similar to SB and controls. Combined MP plus AMV or MP plus SB decreased Po substantially. Combined MP plus CMV, MP plus AMV, or MP plus SB induced myofibrillar disruption that correlated with the reduced Po. αII‐spectrin increased, IGF‐1 decreased, and MAF‐box mRNA increased in both the CMV group and MP plus CMV group. Short‐term, high‐dose MP had no additive effects on CMV‐induced diaphragm dysfunction. Combined MP plus AMV impaired diaphragm function, but AMV alone did not. We found that acute, high‐dose MP produces diaphragm dysfunction depending on the mode of mechanical ventilation. Muscle Nerve, 2011
Treatment of hypokalemic periodic paralysis with topiramate
Authors: Fiore Darren M. , Strober Jonathan B. 
Published: December 2010

AbstractHypokalemic periodic paralysis (hypoPP), the most common form of periodic paralysis, is a disorder characterized by attacks of transient muscle weakness associated with a drop in serum potassium level.The mainstay of treatment is potassium supplementation and drugs that inhibit the enzyme carbonic anhydrase. In this report we describe 11‐year‐old twins with hypoPP who were treated with topiramate, an anti‐epileptic drug known to have carbonic anhydrase inhibitory properties. The patients experienced a decrease in the severity of their attacks upon initiation of treatment. Topiramate may warrant further investigation as a treatment option in hypoPP. Muscle Nerve, 2011
Decentralized receding horizon control with communication bandwidth allocation for multiple vehicle systems
Authors: Izadi H. A. , Gordon B. W. , Rabbath C. A. 
Published: December 2010

SUMMARYIn this paper, a decentralized receding horizon control (DRHC) for a group of cooperative vehicles is investigated where the communication bandwidth is limited. This gives rise to a DRHC problem with communication delays. A new approach is proposed to vary the communication bandwidth for each vehicle, subject to network bandwidth constraints, in order to improve the cooperation performance. In the DRHC approach, each vehicle predicts its future trajectory over a prediction horizon and the neighboring vehicles exchange their predicted trajectories at each sample time to maintain the cooperation objectives. A delayed DRHC architecture is formulated that explicitly accounts for the inter‐vehicle communication delays. Then a bandwidth allocation algorithm is proposed for the delayed DRHC formulation. The key idea with the proposed approach is that each vehicle minimizes an error bound due to the mismatch between the delayed and updated neighbor's trajectories. This allows a dynamic bandwidth allocation to optimize the group performance. Simulation of formation of a group of vehicles is used to demonstrate the effectiveness of the approach. Copyright © 2010 John Wiley & Sons, Ltd.
Intrinsic cell memory reinforces myogenic commitment of pericyte‐derived iPSCs
Authors: Quattrocelli Mattia , Palazzolo Giacomo , Floris Giuseppe , Schöffski Patrick , Anastasia Luigi , Orlacchio Aldo , Vandendriessche Thierry , Chuah Marinee KL , Cossu Giulio , Verfaillie Catherine , Sampaolesi Maurilio 
Published: December 2010

AbstractMesoangioblasts (MABs) are a subset of muscle‐derived pericytes able to restore dystrophic phenotype in mice and dogs. However, their lifespan is limited and they undergo senescence after 25–30 population doublings. Recently, induced pluripotent stem cells (iPSCs) generated from reprogrammed fibroblasts have been demonstrated to have in vitro and in vivo myogenic potential when sorted for the SM/C‐2.6 antigen. Furthermore, chimeric mice from mdx‐iPSCs (DYS‐HAC) cells showed tissue‐specific expression of dystrophin. Nevertheless, myogenic differentiation protocols and the potential of iPSCs generated from different cell sources still present unanswered questions. Here we show that iPSCs generated from prospectively sorted MABs (MAB‐iPSCs) are pluripotent as fibroblast‐derived iPSCs (f‐iPSCs). However, both teratoma formation and genetic cell manipulation assays identify a durable epigenetic memory in MAB‐iPSCs, resulting in stronger myogenic commitment. Striated muscle tissue accounts for up to 70% of MAB‐iPSC teratomas. Moreover, transfection with Pax3 and Pax7 induces a more robust myogenic differentiation in MAB‐iPSCs than in f‐iPSCs. A larger amount of CD56+ progenitors can be sorted from the MAB‐iPSCs differentiating pool and, after transplantation into αsg‐KO mice, can efficiently participate to skeletal muscle regeneration and restore αsg expression. Our data strongly suggest that iPSCs are a heterogeneous population and, when generated from myogenic adult stem cells, they exhibit a stronger commitment, paving the way for creating custom‐made cell protocols for muscular dystrophies. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Clinicians' use of personality disorder models within a particular treatment setting: A longitudinal comparison of temporal consistency and clinical utility
Authors: Samuel Douglas B. , Widiger Thomas A. 
Published: December 2010

AbstractAn active line of current investigation is how the five‐factor model (FFM) of personality disorder might be applied by clinicians and particularly, how clinically useful this model is in comparison to the existing nomenclature. The current study is the first to investigate the temporal consistency of clinicians' application of the FFM and the DSM‐IV‐TR to their own patients. Results indicated that FFM ratings were relatively stable over 6 months of treatment, supporting their use by clinicians, but also indexed potentially important clinical changes. Additionally, ratings of utility provided by the clinicians suggested that the FFM was more useful for clinical decision‐making than was the DSM‐IV‐TR model. We understand the clinical utility findings within the context of previous research indicating that the FFM is most useful among patients who are not prototypic for a personality disorder. Copyright © 2010 John Wiley & Sons, Ltd.
Delirium prevention in terminal cancer: assessment of a multicomponent intervention
Authors: Gagnon Pierre , Allard Pierre , Gagnon Bruno , Mérette Chantal , Tardif François 
Published: December 2010

AbstractObjective: Delirium is a highly prevalent and deleterious disorder in terminally ill cancer patients. We assessed whether a multicomponent preventive intervention was effective in decreasing delirium incidence and severity among cancer patients receiving end‐of‐life care.Methods: A cohort of 1516 patients was followed from admission to death at seven Canadian palliative care centers. In two of these centers, routine care included a delirium preventive intervention targeting physicians (written notice on selective delirium risk factors and inquest on intended medication changes), patients, and their family (orientation to time and place, information about early delirium symptoms). Delirium frequency and severity were compared between patients at the intervention (N = 674) and usual‐care (N = 842) centers based on thrice‐daily symptom assessments with the Confusion Rating Scale.Results: The overall rate of adherence to the intervention was 89.7%. The incidence of delirium was 49.1% in the intervention group, compared with 43.9% in the usual‐care group (odds ratio [OR] 1.23, P = 0.045). When confounding variables were controlled for, no difference was observed between the intervention and the usual‐care groups in delirium incidence (OR 0.94, P = 0.66), delirium severity (1.83 vs 1.92; P = 0.07), total days in delirium (4.57 vs 3.57 days; P = 0.63), or duration of first delirium episode (2.9 vs 2.1 days; P = 0.96). Delirium‐free survival was similar in the two groups.Conclusion: A simple multicomponent preventive intervention was ineffective in reducing delirium incidence or severity among cancer patients receiving end‐of‐life care. Delirium prevention remains a difficult challenge in terminally ill cancer patients. Copyright © 2010 John Wiley & Sons, Ltd.
Depression in lung cancer patients: the role of perceived stigma
Authors: Gonzalez Brian D. , Jacobsen Paul B. 
Published: December 2010

AbstractObjective: Previous research has shown that lung cancer patients are at an increased risk for depressive symptomatology; however, little is known about the factors contributing to depression in these patients. This study focused on the possible association between perceived stigma related to a lung cancer diagnosis and depressive symptomatology. It was hypothesized that greater perceived stigma would be related to greater depressive symptomatology and that perceived stigma would account for variance in depressive symptomatology above and beyond that accounted for by relevant clinical, demographic, and psychosocial variables.Method: A sample of 95 participants receiving chemotherapy for stage II–IV non‐small cell lung cancer was recruited during routine outpatient chemotherapy visits. Participants completed a demographic questionnaire and self‐report measures assessing perceived stigma, depressive symptomatology, and other psychosocial variables. A medical chart review was conducted to assess clinical factors.Results: As hypothesized, there was a positive association between perceived stigma and depressive symptomatology, r = 0.46, p<0.001. Perceived stigma also accounted for significant unique variance in depressive symptomatology above and beyond that accounted for by relevant demographic, clinical, and psychosocial factors, β = 0.19, p<0.05.Conclusions: Future research should aim to replicate and extend these findings in longitudinal studies and explore whether lung cancer patients' depressive symptomatology can be ameliorated by targeting perceived stigma. Copyright © 2010 John Wiley & Sons, Ltd.
Managing a dual role—experiences and coping strategies of parents donating haploidentical G‐CSF mobilized peripheral blood stem cells to their children
Authors: van Walraven S. M. , Ball L. M. , Koopman H. M. , Switzer G. E. , Ropes‐de Jong C. M. H. , de Jong A. , Bredius R. G. M. , Egeler R. M. 
Published: December 2010

AbstractHematopoietic stem cell transplantation is an effective therapy for life‐threatening hematological diseases. Parents may be asked to donate hematopoietic stem cells for their child when no compatible related or unrelated donor is available.Objective: Parents donating G‐CSF mobilized peripheral blood stem cells simultaneously and uniquely fulfill the dual role of donor and caregiver for their ill child. The experiences of both sibling and unrelated stem cell donors have been extensively reported but not those of parental donors.Methods: We therefore undertook a study specifically to investigate the experiences and coping strategies of parental stem cell donors. In‐depth qualitative interviews were conducted with 13 parental donors, which were subsequently transcribed and subjected to thematic analysis. In addition, parental coping was assessed utilizing the Utrecht Coping List.Results: Qualitative analyses revealed four main thematic categories describing the way parental stem cell donation was experienced, namely ‘Hope and Fear’, ‘Need for Information’, ‘Do Anything for your Child’ and ‘Transplant Outcome’ In addition parents noted similar difficulties which were unrelated to their specific role as a donor, for example they felt socially isolated.Conclusions: Individual information for the parents needs to address not only the transplantation procedure but particularly those aspects related to the donation process. We feel there is a need for a protocol specifically designed to support and coach parental donors. Copyright © 2010 John Wiley & Sons, Ltd.
Does psychological adjustment of melanoma survivors differs between genders?
Authors: Hamama‐Raz Y. 
Published: December 2010

AbstractObjective: Survival rates of cancer have significantly increased. However, cancer survivors face physical, psychological and social difficulties, while adjusting to post‐illness status. We examined between‐gender differences in the psychological adjustment (mental well‐being, distress and subjective level of functioning), the putative origin of those differences, and the roles of cognitive appraisal, hardiness and attachment style in the psychological adjustment of melanoma survivors. Methods: Our sample included 300 malignant melanoma survivors (182 women and 118 men). Most were diagnosed in stages IA and IB of the disease, and had no evidence of disease for 5 years or more. Participants completed self‐report questionnaires regarding personal data, adjustment measured by sense of well‐being, distress and subjective functioning, cognitive appraisal (primary and secondary) and personal resources (hardiness and attachment style). Results: Between‐gender differences were revealed in psychological adjustment and in various components of cognitive appraisal and attachment styles. Women revealed more distress, less secondary cognitive appraisal and were more secure in attachment styles. Men showed higher secondary appraisal and were more dismissing‐avoidant in attachment. No between‐group differences were found in mental well‐being, subjective functioning, and primary cognitive appraisal or in the global measure of hardiness. Conclusions: We present social processes that seem to account for gender differences in behavior and response to stress, and psychological explanations for these findings. This study contributes to the field of psycho‐oncology by identifying factors that promote adjustment among melanoma survivors. Copyright © 2010 John Wiley & Sons, Ltd.
Determinants of the burden and positivity of family caregivers of terminally ill cancer patients in Korea
Authors: Park Chang‐Hae , Shin Dong Wook , Choi Jin Young , Kang Jina , Baek Young Ji , Mo Ha Na , Lee Mee‐Sook , Park Seon‐Ju , Park Sang Min , Park Sohee 
Published: December 2010

AbstractObjective: Caregivers may experience positive or negative feelings about their role. The study investigated the determinants of the burden and positivity of family caregivers of Korean terminal cancer patients.Methods: A multicenter cross‐sectional survey was conducted with 139 family caregivers. Determinants of caregiver's burden and positivity were assessed by the Caregiver Reaction Assessment Scale and by three questions based on a previous study, respectively. Two separate hierarchical multiple regression models were used.Results: Each domain of the caregiver's burden and positivity was explained by different factors, with the total explained variance ranging between 14.4–33.6% and 2.6–18.3%, respectively. Caregivers who were unmarried, less educated, and/or had low incomes were more likely to be negatively affected, while those who shared caregiving responsibilities were less prone to negative consequences. Caregivers who were male, religious practitioners, and who perceived a higher burden of schedule disruptions were more likely to have a positive perception of their role, while those who perceived a lack of family support were less likely.Conclusions: Our results highlight the importance of sharing the caregiving burden with the other family members. Organizing a family meeting can provide an opportunity for other family members to acknowledge the feelings and reactions of the primary caregivers, and can prompt the sharing of caregiving responsibilities. Copyright © 2010 John Wiley & Sons, Ltd.
Cancer Treatment Survey (CaTS): development and validation of a new instrument to measure patients' preparation for chemotherapy and radiotherapy
Authors: Schofield Penelope , Gough Karla , Ugalde Anna , Carey Mariko , Aranda Sanchia , Sanson‐Fisher Rob 
Published: December 2010

AbstractObjective: Cancer patients experience high levels of pre‐treatment anxiety. Chemotherapy and radiotherapy are threatening medical procedures. Preparation for these procedures should include the provision of sensory and procedural information, and addressing fears. The aim of this study was to develop a cancer treatment survey (CaTS) to assess the preparation for chemotherapy and radiotherapy in cancer patients.Methods: Drawing on evidence for how to prepare patients for threatening procedures, items were generated by psychosocial/clinical experts and pilot tested with cancer patients. The 36‐item draft CaTS was administered to 192 cancer patients commencing chemotherapy for lymphoma, breast or colon cancer. Participants also completed the Hospital Anxiety and Depression Scale (HADS) and basic medical and demographic information was recorded.Results: A systematic process of item selection removed 11 items. Factor analysis indicated a two‐factor solution, with 11 items representing sensory/psychological concerns and 14 items representing procedural concerns. The two subscales demonstrated excellent internal reliability with Cronbach's alpha both over 0.90 and the average inter‐item correlation for each scale exceeded 0.30. Divergent validity was established for both CaTS subscales with the HADS‐A and‐T (allr<0.30). Younger participants (under 65 years of age) had significantly greater procedural concerns (p= 0.001; medium effect).Conclusions: The CaTS is a two factor, 25‐item measure that assesses sensory/psychological concerns and procedural concerns relating to cancer treatment. The instrument provides a reliable and valid outcome measure for interventions to prepare cancer patients for chemotherapy and radiotherapy. Copyright © 2010 John Wiley & Sons, Ltd.