bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single‐Atom Iron Catalyst as an Advanced Redox Mediator for Anodic Oxidation of Organic Electrosynthesis
Authors: Wang Xin‐Yu , Pan Yong‐Zhou , Yang Jiarui , Li Wen‐Hao , Gan Tao , Pan Ying‐Ming , Tang Hai‐Tao , Wang Dingsheng 
Published: April 2024

AbstractHomogeneous electrocatalysts can indirect oxidate the high overpotential substrates through single‐electron transfer on the electrode surface, enabling efficient operation of organic electrosynthesis catalytic cycles. However, the problems of this chemistry still exist such as high dosage, difficult recovery, and low catalytic efficiency. Single‐atom catalysts (SACs) exhibit high atom utilization and excellent catalytic activity, hold great promise in addressing the limitations of homogeneous catalysts. In view of this, we have employed Fe‐SA@NC as an advanced redox mediator to try to change this situation. Fe‐SA@NC was synthesized using an encapsulation‐pyrolysis method, and it demonstrated remarkable performance as a redox mediator in a range of reported organic electrosynthesis reactions, and enabling the construction of various C−C/C−X bonds. Moreover, Fe‐SA@NC demonstrated a great potential in exploring new synthetic method for organic electrosynthesis. We employed it to develop a new electro‐oxidative ring‐opening transformation of cyclopropyl amides. In this new reaction system, Fe‐SA@NC showed good tolerance to drug molecules with complex structures, as well as enabling flow electrochemical syntheses and gram‐scale transformations. This work highlights the great potential of SACs in organic electrosynthesis, thereby opening a new avenue in synthetic chemistry.
High‐Pressure‐Field Induced Synthesis of Ultrafine‐Sized High‐Entropy Compounds with Excellent Sodium‐Ion Storage
Authors: Liang Ming , Xie Haonan , Chen Biao , Qin Hongye , Zhang Hanwen , Wang Jingyi , Sha Junwei , Ma Liying , Liu Enzuo , Kang Jianli , Shi Chunsheng , He Fang , Han Xiaopeng , Hu Wenbin , Zhao Naiqin , He Chunnian 
Published: April 2024

AbstractEmerging high entropy compounds (HECs) have attracted huge attention in electrochemical energy‐related applications. The features of ultrafine size and carbon incorporation show great potential to boost the ion‐storage kinetics of HECs. However, they are rarely reported because high‐temperature calcination tends to result in larger crystallites, phase separation, and carbon reduction. Herein, using the NaCl self‐assembly template method, by introducing a high‐pressure field in the calcination process, the atom diffusion and phase separation are inhibited for the general formation of HECs, and the HEC aggregation is inhibited for obtaining ultrafine size. The general preparation of ultrafine‐sized (<10 nm) HECs (nitrides, oxides, sulfides, and phosphates) anchored on porous carbon composites is realized. They are demonstrated by combining advanced characterization technologies with theoretical computations. Ultrafine‐sized high entropy sulfides‐MnFeCoCuSnMo/porous carbon (HES‐MnFeCoCuSnMo/PC) as representative anodes exhibit excellent sodium‐ion storage kinetics and capacities (a high rating capacity of 278 mAh g−1 at 10 A g−1 for full cell and a high cycling capacity of 281 mAh g−1 at 20 A g−1 after 6000 cycles for half cell) due to the combining advantages of high entropy effect, ultrafine size, and PC incorporation. Our work provides a new opportunity for designing and fabricating ultrafine‐sized HECs.
Efficiency of novel polyionic liquid toward the chemical separation of petroleum crude oil emulsions
Authors: Abdullah Mahmood M. S. , Al‐Lohedan Hamad A. , Faqihi Noorah A. 
Published: April 2024

AbstractIn the present study, a new polyionic liquid, PEST‐BU, were synthesized and characterized using proton nuclear magnetic resonance, Fourier transform infrared spectroscopy, pendant drop technique, and thermal gravimetric analysis. The efficiency of PEST‐BU and its parent (PE‐ST) for separating petroleum crude oil emulsion was explored using several affecting parameters, including water ratio, separation time, pH, temperature, and demulsifier concentration. The results indicated that PEST‐BU exhibited higher separation efficiency (SE) than PE‐ST. In addition, the results revealed that the increased water ratio, separation time, temperature, and demulsifier concentration promoted the SE of PE‐ST and PEST‐BU. The data also showed that the optimal pH value to achieve maximum SE is 7; however, the SE of PE‐ST and PEST‐BU in acidic and basic mediums declined, possibly due to the increasing polarity of water droplets in these mediums, which increased electrostatic repulsion between them, increasing oil emulsion stability.
Murder‐suicide in post‐Katrina New Orleans: A perfect storm of multidetermined causes
Authors: Griffies W. Scott 
Published: April 2024

AbstractThis applied psychoanalytic paper explores the phenomenon of murder‐suicide in post‐Katrina New Orleans, focusing on the case of Zack Bowen and Addie Hall. The aftermath of natural disasters like Hurricane Katrina often leads to increased mental health issues, including violence and suicide. The author, who lived and practiced psychiatry in the New Orleans French Quarter (FQ), was involved in a documentary about the couple, providing a unique perspective on their tragic story. Zack Bowen, a veteran of Iraq and Kosovo with post‐traumatic stress disorder (PTSD) symptoms, and Addie Hall, an artist with a history of abuse, were star‐crossed lovers in the post‐apocalyptic FQ. In the immediate aftermath of the storm, with the higher socioeconomic population evacuated, the city experienced lawlessness, but also a bond between subcultural groups seeking anarchy, freedom, escapism, and avoidance of past troubles. Drawing from excerpts of the documentary and material from a book about the couple entitled Shake the Devil Off, this paper utilizes an object relational framework to understand the multidetermined causes of the murder‐suicide. It highlights how disasters can bring individuals together in desperate situations, destabilize social connections, and exacerbate avoidant defenses through increased substance abuse. Furthermore, it reveals how such traumatic events can reopen past wounds, including PTSD and experiences of abuse, creating a mental health crisis that extends far beyond the initial impact of the storm. It also underscores the significance of interpersonal containment of toxic projections in the aftermath of a disaster, particularly for individuals with intrapsychic vulnerabilities.
Harnessing Ash for Sustainable CO2Absorption: Current Strategies and Future Prospects
Authors: Wu Wen‐Ya , Zhang Mingsheng , Wang Cun , Tao Longgang , Bu Jie , Zhu Qiang 
Published: April 2024

AbstractThis review explores the potential of using different types of ash, namely fly ash, biomass ash, and coal ash etc., as mediums for CO2capture and sequestration. The diverse origins of these ash types – municipal waste, organic biomass, and coal combustion – impart unique physicochemical properties that influence their suitability and efficiency in CO2absorption. This review first discusses the environmental and economic implications of using ash wastes, emphasizing the reduction in landfill usage and the transformation of waste into value‐added products. Then the chemical/physical treatments of ash wastes and their inherent capabilities in binding or reacting with CO2are introduced, along with current methodologies utilize these ashes for CO2sequestration, including mineral carbonation and direct air capture techniques. The application of using ash wastes for CO2capture are highlighted, followed by the discussion regarding challenges associated with ash‐based CO2absorption approach. Finally, the article projects into the future, proposing innovative approaches and technological advancements needed to enhance the efficacy of ash in combating the increasing CO2levels. By providing a comprehensive analysis of current strategies and envisioning future prospects, this review aims to contribute to the field of sustainable CO2absorption and environmental management.
Optimal iterative feedforward parameter tuning for varying trajectory under actuator constraints
Authors: Yang Liangliang , Yu Kaixin , Zhang Hui , Lu Wenqi 
Published: April 2024

AbstractThis paper presents a feedforward control algorithm that combines the benefits of optimal iterative learning control (OILC) and model‐based feedforward control (MFC) using iterative feedforward tuning and input shaping filter (IFT‐ISF) for industrial motion systems. OILC effectively compensates for tracking errors in repeating tasks under actuator constraints. However, its performance deteriorates when the trajectory changes. In contrast, MFC can achieve high performance for varying trajectory tracking tasks, but its performance may degrade for constrained systems if the control force exceeds the actuator saturation boundary. The proposed algorithm aims to overcome these limitations to achieve optimal trajectory tracking performance for varying trajectories under actuator constraints. Simulation and experimental results demonstrate that the proposed algorithm achieves optimal tracking performance while complying with the actuator constraints. The algorithm provides a data‐driven approach without requiring the tedious process of model identification. By combining the benefits of OILC and IFT‐ISF, the proposed algorithm can achieve high‐performance trajectory tracking for both repeating and varying tasks under actuator constraints, making it suitable for industrial motion systems.
A fractional‐order active disturbance rejection control for permanent magnet synchronous motor position servo system
Authors: Wang Shaohua , Li Bolin , Chen Pengchong , Yu Wei , Peng Yibing , Luo Ying 
Published: April 2024

AbstractThis paper introduces a novel control scheme for the permanent magnet synchronous motor (PMSM) position servo system using a fractional‐order active disturbance rejection control (ADRC) approach. Specifically, a first‐order ADRC is employed in the current loop, while a fractional‐order ADRC is designed for the position loop. In the latter, a linear extended state observer (LESO) is utilized to estimate and compensate for disturbances, while a fractional‐order proportional derivative (FO[PD]) feedback controller is employed to enhance the control performance. Moreover, a parameter tuning method is presented based on frequency domain specifications. This technique utilizes the flat phase constraint as a design constraint to ensure that the phase is flat near the gain crossover frequency, thus ensuring that the closed‐loop system remains robust to loop gain variations. Simulation and experimental results demonstrate that the proposed fractional‐order ADRC control scheme yields improved dynamic response, disturbance rejection, and robustness to loop gain variations.
Predictive processing of music and language in autism: Evidence from Mandarin and English speakers
Authors: Zhao Chen , Ong Jia Hoong , Veic Anamarija , Patel Aniruddh D. , Jiang Cunmei , Fogel Allison R. , Wang Li , Hou Qingqi , Das Dipsikha , Crasto Cara , Chakrabarti Bhismadev , Williams Tim I. , Loutrari Ariadne , Liu Fang 
Published: April 2024

AbstractAtypical predictive processing has been associated with autism across multiple domains, based mainly on artificial antecedents and consequents. As structured sequences where expectations derive from implicit learning of combinatorial principles, language and music provide naturalistic stimuli for investigating predictive processing. In this study, we matched melodic and sentence stimuli in cloze probabilities and examined musical and linguistic prediction in Mandarin‐ (Experiment 1) and English‐speaking (Experiment 2) autistic and non‐autistic individuals using both production and perception tasks. In the production tasks, participants listened to unfinished melodies/sentences and then produced the final notes/words to complete these items. In the perception tasks, participants provided expectedness ratings of the completed melodies/sentences based on the most frequent notes/words in the norms. While Experiment 1 showed intact musical prediction but atypical linguistic prediction in autism in the Mandarin sample that demonstrated imbalanced musical training experience and receptive vocabulary skills between groups, the group difference disappeared in a more closely matched sample of English speakers in Experiment 2. These findings suggest the importance of taking an individual differences approach when investigating predictive processing in music and language in autism, as the difficulty in prediction in autism may not be due to generalized problems with prediction in any type of complex sequence processing.
Accelerated generation of gene‐engineered monoclonal CHO cell lines using FluidFM nanoinjection and CRISPR/Cas9
Authors: Antony Justin S. , Herranz Anabel Migenda , Mohammadian Gol Tahereh , Mailand Susanne , Monnier Paul , Rottenberger Jennifer , Roig‐Merino Alicia , Keller Bettina , Gowin Claudia , Milla Maria , Beyer Tobias A. , Mezger Markus 
Published: April 2024

AbstractChinese hamster ovary (CHO) cells are the commonly used mammalian host system to manufacture recombinant proteins including monoclonal antibodies. However unfavorable non‐human glycoprofile displayed on CHO‐produced monoclonal antibodies have negative impacts on product quality, pharmacokinetics, and therapeutic efficiency. Glycoengineering such as genetic elimination of genes involved in glycosylation pathway in CHO cells is a viable solution but constrained due to longer timeline and laborious workflow. Here, in this proof‐of‐concept (PoC) study, we present a novel approach coined CellEDIT to engineer CHO cells by intranuclear delivery of the CRISPR components to single cells using the FluidFM technology. Co‐injection of CRISPR system targeting BAX, DHFR, and FUT8 directly into the nucleus of single cells, enabled us to generate triple knockout CHO‐K1 cell lines within a short time frame. The proposed technique assures the origin of monoclonality without the requirement of limiting dilution, cell sorting or positive selection. Furthermore, the approach is compatible to develop both single and multiple knockout clones (FUT8, BAX, and DHFR) in CHO cells. Further analyses on single and multiple knockout clones confirmed the targeted genetic disruption and altered protein expression. The knockout CHO‐K1 clones showed the persistence of gene editing during the subsequent passages, compatible with serum free chemically defined media and showed equivalent transgene expression like parental clone.
Overexpression of YTHDF3 increases the specific productivity of the recombinant protein in CHO cells by promoting the translation process
Authors: Cui Zhao‐ming , Feng Ying‐ying , Gao Yan‐ping , Wang Hai‐tong , Lu Jiang‐tao , Guo Jia‐liang , Xu Hong‐yan , Qiu Le‐le , Wang Tian‐yun , Jia Yan‐long 
Published: April 2024

AbstractDue to their high‐quality characteristics, Chinese hamster ovary (CHO) cells have become the most widely used and reliable host cells for the production of recombinant therapeutic proteins in the biomedical field. Previous studies have shown that the m6A reader YTHDF3, which contains the YTH domain, can affect a variety of biological processes by regulating the translation and stability of target mRNAs. This study investigates the effect of YTHDF3 on transgenic CHO cells. The results indicate that stable overexpression of YTHDF3 significantly enhances recombinant protein expression without affecting host cell growth. Transcriptome sequencing indicated that several genes, including translation initiation factor, translation extension factor, and ribosome assembly factor, were upregulated in CHO cells overexpressing YTHDF3. In addition, cycloheximide experiments confirmed that YTHDF3 enhanced transgene expression by promoting translation in CHO cells. In conclusion, the findings in this study provide a novel approach for mammalian cell engineering to increase protein productivity by regulating m6A.
Survival trends for left and right sided colon cancer using population‐based SEER database: A forty‐five‐year analysis from 1975 to 2019
Authors: Ulanja Mark B. , Asafo‐Agyei Kwabena Oppong , Neelam Vijay , Beutler Bryce D. , Antwi‐Amoabeng Daniel , Governor Samuel B. , Rahman Ganiyu A. , Djankpa Francis T. , Ulanja Reginald N. , Nteim Grace B. , Mabrouk Tarig , Amankwah Millicent , Alese Olatunji B. 
Published: April 2024

AbstractBackgroundSurvival differences between left‐sided colon cancer (LSCC) and right‐sided colon cancer (RSCC) has been previously reported with mixed results, with various study periods not accounting for other causes of mortality.PurposeWe sought to assess the trends in colon cancer cause‐ specific survival (CSS) and overall survival (OS) based on sidedness.MethodFine‐Gray competing risk and Cox models were used to analyze Surveillance, Epidemiology, and End Results (SEER) population‐based cohort from 1975 to 2019. Various interval periods were identified based on the timeline of clinical adoption of modern chemotherapy (1975–1989, interval period A; 1990–2004, B; and 2005–2019, C).ResultsOf the 227,637 patients, 50.1% were female and 46.2% were RSCC. RSCC was more common for African Americans (51.5%), older patients (age ≥65; 51.4%), females (50.4%), while LSCC was more common among Whites (53.1%; p < 0.001), younger patients (age 18–49, 64.6%; 50–64, 62.3%; p < 0.001), males (58.1%; p < 0.001). The Median CSS for LSCC and RCC were 19.3 and 16.7 years respectively for interval period A (1975–1989). Median CSS for interval periods B and C were not reached (more than half of the cohort was still living at the end of the follow‐up period). Adjusted CSS was superior for LSCC versus RSCC for the most recent interval period C (HR 0.89; 0.86–0.92; p < 0.001). LSCC consistently showed superior OS for all study periods. Stage stratification showed worse CSS for localized and regional LSCC in the earlier study periods, but the risk attenuated over time. However, left sided distant disease had superior CSS per stage for all interval periods. OS was better for LSCC irrespective of stage, with gradual improvement over time.ConclusionLSCC was associated with superior survival compared to right sided tumors. With the adoption of modern chemotherapy regimens, prognosis between LSCC and RSCC became more divergent in favor of LSCC. Colon cancer clinical trials should strongly consider tumor sidedness as an enrollment factor.
Hemodynamics of low‐pressure cardiac tamponade: An illustrative case report
Authors: Thach Rasmey , Blank Robert , Lin Charles 
Published: April 2024

AbstractA 55‐year‐old male with acute pericarditis presented with low‐pressure cardiac tamponade (LPCT) unresponsive to volume infusion. Subsequent pericardiocentesis resulted in hemodynamic improvement and unmasking of pericardial constriction. This case provides illustrative hemodynamic tracings of LPCT. Additionally, the presence of concurrent pericardial constriction that may indicate a plausible underlying mechanism for the blunted responsiveness to fluid expansion in LPCT. The underlying physiologic processes and the associated hemodynamic tracings are discussed.
Parosteal lipoma of the left femur: A case report
Authors: Waters James P. , Horenstein Sydney , Egger Austin , Johnsen Parker , Kim Tae Won 
Published: April 2024

Key Clinical MessageMultidisciplinary team collaboration in the diagnosis of rare tumors such as parosteal lipoma is highly important, especially when suspicious of malignancy. The use of radiological and physical examinations is imperative to monitor recurrence and quality of life.
Comparative Pharmacokinetics and Safety Assessment of 1st‐ and 2nd‐Generation Zinpentraxin Alfa Drug Products in Healthy Volunteers: A Randomized Crossover Study
Authors: Mai Tu H. , Yadav Rajbharan , Arjomandi Audrey , Jung Christine , Meier Monika M. , Donaldson Francis , Zhao Rui , Ding Han‐Ting , Hsu Joy C. , Kamath Nikhil , Pan Lin 
Published: April 2024

AbstractZinpentraxin alfa is a recombinant form of the human pentraxin‐2 that was studied in idiopathic pulmonary fibrosis (IPF). To improve the purity and yield of the drug material, a 2nd‐generation drug product was developed. To characterize and compare the pharmacokinetic (PK) properties of the 1st‐ and 2nd‐generation zinpentraxin alfa, PK studies were conducted in healthy volunteers (HVs). In a phase 1 randomized, double‐blind, 2‐sequence crossover, sequential 2‐stage study (ISRCTN59409907), single intravenous (IV) doses of 1st‐ and 2nd‐generation zinpentraxin alfa at 10 mg/kg were studied with a blinded interim analysis (IA) at the end of stage 1. Bioequivalence (BE) was achieved for the maximum observed plasma concentration (Cmax), but the overall exposure was higher for the 2nd‐ compared to the 1st‐generation zinpentraxin alfa. The study was stopped after stage 1 as the gating criteria were met based on the result of the blinded IA. Safety profiles were similar for the 1st‐ and 2nd‐generation drug products, and antidrug antibody (ADA) was not observed in this study.
OMIP‐104: A 30‐color spectral flow cytometry panel for comprehensive analysis of immune cell composition and macrophage subsets in mouse metabolic organs
Authors: Lambooij Joost M. , Tak Tamar , Zaldumbide Arnaud , Guigas Bruno 
Published: April 2024

AbstractObesity‐induced chronic low‐grade inflammation, also known as metaflammation, results from alterations of the immune response in metabolic organs and contributes to the development of fatty liver diseases and type 2 diabetes. The diversity of tissue‐resident leukocytes involved in these metabolic dysfunctions warrants an in‐depth immunophenotyping in order to elucidate disease etiology. Here, we present a 30‐color, full spectrum flow cytometry panel, designed to (i) identify the major innate and adaptive immune cell subsets in murine liver and white adipose tissues and (ii) discriminate various tissue‐specific myeloid subsets known to contribute to the development of metabolic dysfunctions. This panel notably allows for distinguishing embryonically‐derived liver‐resident Kupffer cells from newly recruited monocyte‐derived macrophages and KCs. Furthermore, several adipose tissue macrophage (ATM) subsets, including perivascular macrophages, lipid‐associated macrophages, and pro‐inflammatory CD11c+ ATMs, can also be identified. Finally, the panel includes cell‐surface markers that have been associated with metabolic activation of different macrophage and dendritic cell subsets. Altogether, our spectral flow cytometry panel allows for an extensive immunophenotyping of murine metabolic tissues, with a particular focus on metabolically‐relevant myeloid cell subsets, and can easily be adjusted to include various new markers if needed.