bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical Handover Core Outcome Measures (SH-CORE): a protocol for the development of a core outcome set for trials in surgical handover
Authors: Ryan Jessica M. , Devane Declan , Simiceva Anastasija , Eppich Walter , Kavanagh Dara O. , Cullen Christine , Hogan Aisling M. , McNamara Deborah A. 
Published: June 2024

Abstract
Background
Surgical handover is associated with a significant risk of care failures. Existing research displays methodological deficiencies and little consensus on the outcomes that should be used to evaluate interventions in this area. This paper reports a protocol to develop a core outcome set (COS) to support standardisation, comparability, and evidence synthesis in future studies of surgical handover between doctors.

Methods
This study adheres to the Core Outcome Measures in Effectiveness Trials (COMET) initiative guidance for COS development, including the COS-Standards for Development (COS-STAD) and Reporting (COS-STAR) recommendations. It has been registered prospectively on the COMET database and will be led by an international steering group that includes surgical healthcare professionals, researchers, and patient and public partners. An initial list of reported outcomes was generated through a systematic review of interventions to improve surgical handover (PROSPERO: CRD42022363198). Findings of a qualitative evidence synthesis of patient and public perspectives on handover will augment this list, followed by a real-time Delphi survey involving all stakeholder groups. Each Delphi participant will then be invited to take part in at least one online consensus meeting to finalise the COS.

Ethics and dissemination
This study was approved by the Royal College of Surgeons in Ireland (RCSI) Research Ethics Committee (202309015, 7th November 2023). Results will be presented at surgical scientific meetings and submitted to a peer-reviewed journal. A plain English summary will be disseminated through national websites and social media. The authors aim to integrate the COS into the handover curriculum of the Irish national surgical training body and ensure it is shared internationally with other postgraduate surgical training programmes. Collaborators will be encouraged to share the findings with relevant national health service functions and national bodies.

Discussion
This study will represent the first published COS for interventions to improve surgical handover, the first use of a real-time Delphi survey in a surgical context, and will support the generation of better-quality evidence to inform best practice.

Trial registration
Core Outcome Measures in Effectiveness Trials (COMET) initiative 2675. http://www.comet-initiative.org/Studies/Details/2675.
Investigating non-inferiority of internet-delivered versus face-to-face cognitive behavioural therapy for insomnia (CBT-I): a randomised controlled trial (iSleep well)
Authors: Benz F. , Grolig L. , Hannibal S. , Buntrock C. , Cuijpers P. , Domschke K. , Ebert D. D. , Ell J. , Janneck M. , Jenkner C. , Johann A. F. , Josef A. , Kaufmann M. , Koß A. , Mallwitz T. , Mergan H. , Morin C. M. , Riemann D. , Riper H. , Schmid S. R. , Smit F. , Spille L. , Steinmetz L. , Van Someren E. J. W. , Spiegelhalder K. , Lehr D. 
Published: June 2024

Abstract
Background
Insomnia is a highly prevalent disorder associated with numerous adverse health outcomes. Cognitive behavioural therapy for insomnia (CBT-I) is recommended as first-line treatment by clinical guidelines but is accessible to only a minority of patients suffering from insomnia. Internet-delivered CBT-I (iCBT-I) could contribute to the widespread dissemination of this first-line treatment. As there is insufficient evidence regarding non-inferiority, this study directly aims to compare therapist-guided internet-delivered versus face-to-face CBT-I in terms of insomnia severity post-treatment. Furthermore, a health-economic evaluation will be conducted, and potential benefits and disadvantages of therapist-guided iCBT-I will be examined.

Methods
This study protocol describes a randomised controlled two-arm parallel-group non-inferiority trial comparing therapist-guided iCBT-I with face-to-face CBT-I in routine clinical care. A total of 422 patients with insomnia disorder will be randomised and treated at 16 study centres throughout Germany. Outcomes will be assessed at baseline, 10 weeks after randomisation (post), and 6 months after randomisation (follow-up). The primary outcome is insomnia severity measured using the Insomnia Severity Index. Secondary outcomes include depression-related symptoms, quality of life, fatigue, physical activity, daylight exposure, adverse events related to treatment, and a health-economic evaluation. Finally, potential moderator variables and several descriptive and exploratory outcomes will be assessed (e.g. benefits and disadvantages of internet-delivered treatment).

Discussion
The widespread implementation of CBT-I is a significant healthcare challenge. The non-inferiority of therapist-guided iCBT-I versus face-to-face CBT-I will be investigated in an adequately powered sample in routine clinical care, with the same therapeutic content and same level of therapist qualifications provided with both interventions. If this trial demonstrates the non-inferiority of therapist-guided iCBT-I, healthcare providers may be more confident recommending this treatment to their patients, contributing to the wider dissemination of CBT-I.

Trial registration
Trial registration number in the German Clinical Trials Register: DRKS00028153 (https://drks.de/search/de/trial/DRKS00028153). Registered on 16th May 2023.
Geometry, reactivity descriptors, light harvesting efficiency, molecular radii, diffusion coefficient, and oxidation potential of RE(I)(CO)3Cl(TPA-2, 2′-bipyridine) in DSSC application: DFT/TDDFT study
Authors: Tegegn Dereje Fedasa , Belachew Habtamu Zewude , Wirtu Shuma Fayera , Salau Ayodeji Olalekan 
Published: June 2024

AbstractDye-sensitized solar cells (DSSCs) are an excellent alternative solar cell technology that is cost-effective and environmentally friendly. The geometry, reactivity descriptors, light-harvesting efficiency, molecular radii, diffusion coefficient, and excited oxidation state potential of the proposed complex were investigated. The calculations in this study were performed using DFT/TDDFT method with B3LYP functional employed on the Gaussian 09 software package. The calculations were used the 6–311 +  + G(d, p) basis set for the C, H, N, O, Cl atoms and the LANL2DZ basis set for the Re atom, with the B3LYP functional.. The balance of hole and electron in this complex has increased the efficiency and lifetime of DSSCs for photovoltaic cell applications. The investigated compound shows that the addition of the TPA substituent marginally changes the geometric structures of the 2, 2′-bipyridine ligand in the T1 state. As EDsubstituents were added to the compound, the energy gap widened and moved from ELUMO (− 2.904 eV) (substituted TPA) to ELUMO (− 3.122 eV) (unsubstituted). In the studying of solvent affects; when the polarity of the solvent decreases, red shifts appears in the lowest energy an absorption and emission band. Good light-harvesting efficiency, molecular radii, diffusion coefficient, excited state oxidation potential, emission quantum yield, and DSSC reorganization energy, the complex is well suited for use as an emitter in dye-sensitized solar cells. Among the investigated complexes mentioned in literature, the proposed complex was a suitable candidate for phosphorescent DSSC.
Multidisciplinary, multicomponent interventions to reduce frailty among older persons in residents of residential care facilities: a scoping review
Authors: Ambagtsheer R. C. , Leach M. J. , O’Brien L. M. , Tyndall J. , Wardle J. , Beilby J. 
Published: June 2024

AbstractBackgroundFrailty reduction and reversal have been addressed successfully among older populations within community settings. However, these findings may not be applicable to residential care settings, largely due to the complex and multidimensional nature of the condition. Relatively, few attempts at frailty prevention exist in residential settings. This review aims to identify and describe best practice models of care for addressing frailty among older populations in residential care settings. This research also sets out to explore the impact of multidisciplinary health service delivery models on health outcomes such as mortality, hospitalisations, quality of life, falls and frailty.MethodsA scoping review of the literature was conducted to address the project objectives. Reference lists of included studies, bibliographic databases and the grey literature were systematically searched for literature reporting multidisciplinary, multidimensional models of care for frailty.ResultsThe scoping review found no interventions that met the inclusion criteria. Of the 704 articles screened, 664 were excluded as not relevant. Forty articles were fully assessed, and while no eligible studies were found, relevant data were extracted from 10 near-eligible studies that reported single disciplines or single dimensions rather than a model of care. The physical, nutritional, medicinal, social and cognitive aspects of the near eligible studies have been discussed as playing a key role in frailty reduction or prevention care models.ConclusionThis review has identified a paucity of interventions for addressing and reducing frailty in residential care settings. High-quality studies investigating novel models of care for addressing frailty in residential care facilities are required to address this knowledge gap. Similarly, there is a need to develop and validate appropriate screening and assessment tools for frailty in residential care populations. Health service providers and policy-makers should also increase their awareness of frailty as a dynamic and reversible condition. While age is a non-modifiable predictor of frailty, addressing modifiable factors through comprehensive care models may help manage and prevent the physical, social and financial impacts of frailty in the ageing population.
Do current energy policies in Germany promote the use of biomass in areas where it is particularly beneficial to the system? Analysing short- and long-term energy scenarios
Authors: Jordan Matthias , Meisel Kathleen , Dotzauer Martin , Schindler Harry , Schröder Jörg , Cyffka Karl-Friedrich , Dögnitz Niels , Naumann Karin , Schmid Christopher , Lenz Volker , Daniel-Gromke Jaqueline , de Paiva Gabriel Costa , Esmaeili Aliabadi Danial , Szarka Nora , Thrän Daniela 
Published: June 2024

Abstract
Background
Policymakers are tasked with both driving the rapid expansion of renewable energy technologies and, additionally channelling the limited national potential of biomass into areas where it can provide the greatest benefit to the energy system. But do current policy instruments promote the use of biomass in these areas? As biomass is limited, its use must be sustainable without leading to further biodiversity loss or depleting forest or soil resources. In this study, short-term energy scenarios are generated using the BenOpt model, which take into account both current and alternative policy instruments under limited biomass utilisation. The results are compared with long-term, cost-optimal energy scenarios for the use of biomass.

Results
The analysis reveals that the instrument of a GHG quota does not promote the use of biofuels in hard-to-electrify areas of the transport sector, where they should be cost-optimally allocated according to long-term energy scenarios. Biofuels are promoted for use in passenger road transport and not in the shipping or aviation sector. In contrast, alternative policy scenarios indicate that the sole instrument of a high CO2 price is more conducive to direct electrification and could displace more fossil fuels by 2030 than the GHG quota alone. This instrument also promotes the optimal use of biogas plants in the power sector in accordance with long-term cost-optimal developments.

Conclusions
The instrument of a GHG quota might lead to counterproductive developments in passenger road transport, but it also helps to ramp up the biofuel capacities required in shipping and aviation in the long term. However, it does not provide the necessary incentives for the ramp-up of battery electric vehicles, which would be the cost optimal solution in passenger road transport according to the long-term scenarios. Even though alternative policy scenarios show that the sole instrument of a high CO2-price is more conducive to direct electrification, a high CO2 price alone is not enough (e.g. in the heat sector) to promote the efficient use of biomass instead of simply covering the base load demand.
Establishment of a circRNA-regulated E3 ubiquitin ligase signature and nomogram to predict immunotherapeutic efficacy and prognosis in hepatocellular carcinoma
Authors: Wu Gefeng , Zhang Jiahao , Peng Rui , Cao Jun , Tu Daoyuan , Zhou Jie , Su Bingbing , Jin Shengjie , Jiang Guoqing , Zhang Chi , Bai Dousheng 
Published: June 2024

Abstract
Background
Hepatocellular carcinoma (HCC) is a common type of malignant tumor where the prognosis is dismal. Circular RNA (CircRNA) is a novel RNA that regulates downstream gene transcription and translation to influence the progression of HCC. However, the regulatory relationship that exists between E3 ligases, which is a class of post-translational modifying proteins, and circRNA remains unclear.

Methods
Based on the E3 ubiquitin ligase in the competitive endogenous RNA (ceRNA) network, a circRNA-regulated E3 ubiquitin ligase signature (CRE3UL) was developed. A CRE3UL signature was created using the least absolute shrinkage and selection operator (Lasso) and Cox regression analysis and merged it with clinicopathologic characteristics to generate a nomogram for prognosis prediction. The pRRophetic algorithm was utilized and immunological checkpoints were analyzed to compare the responses of patients in the high-risk group (HRG) and low-risk group (LRG) to targeted therapy and immunotherapy. Finally, experimental research will further elucidate the relationship between E3 ubiquitin ligase signature and HCC.

Results
HRG patients were found to have a worse prognosis than LRG patients. Furthermore, significant variations in prognosis were observed among different subgroups based on various clinical characteristics. The CRE3UL signature was identified as being an independent prognostic indicator. The nomogram that combined clinical characteristics and the CRE3UL signature was found to accurately predict the prognosis of HCC patients and demonstrated greater clinical utility than the current TNM staging approach. According to anticancer medication sensitivity predictions, the tumors of HRG patients were more responsive to gefitinib and nilotinib. From immune-checkpoint markers analysis, immunotherapy was identified as being more probable to assist those in the HRG.

Conclusions
We found a significant correlation between the CRE3UL signature and the tumor microenvironment, enabling precise prognosis prediction for HCC patients. Additionally, a nomogram was developed that performs well in predicting the overall survival (OS) of HCC patients. This provides valuable guidance for clinicians in devising specific personalized treatment strategies.

Graphical Abstract
Effects of methionine supplementation in a reduced protein diet on growth performance, oxidative status, intestinal health, oocyst shedding, and methionine and folate metabolism in broilers under Eimeria challenge
Authors: Liu Guanchen , Choppa Venkata Sesha Reddy , Sharma Milan Kumar , Ko Hanseo , Choi Janghan , Kim Woo Kyun 
Published: June 2024

Abstract
Background
This study investigated effects of different methionine (Met) supplementation levels in a reduced protein diet on growth performance, intestinal health, and different physiological parameters in broilers under Eimeria challenge. A total of 600 fourteen-day-old Cobb500 male broilers were challenged with E. maxima, E. tenella, and E. acervulina, and randomly allocated in a 2 × 5 factorial arrangement. Birds received normal protein diets (20% crude protein, NCP) or reduced protein diets (17% crude protein, LCP), containing 2.8, 4.4, 6.0, 7.6, and 9.2 g/kg of Met.

Results
On 6 and 9 days post inoculation (DPI), increasing Met level linearly improved the growth performance (P < 0.05). Total oocyst shedding linearly increased as Met level increased (P < 0.05). Duodenal villus height (VH):crypt depth (CD) in the LCP groups were higher on 6 DPI (P < 0.01) while lower on 9 DPI (P < 0.05) compared to the NCP groups. Jejunal CD and duodenal VH:CD changed quadratically as Met level increased (P < 0.05). On 6 DPI, liver glutathione (GSH) and glutathione disulfide (GSSG) linearly increased as Met level increased (P < 0.05). On 9 DPI, GSSG quadratically increased, whereas GSH:GSSG quadratically decreased as Met levels increased (P < 0.05). The expression of amino acid transporters linearly decreased as Met level increased (P < 0.05). The expression of zonula occludens 2 and claudin-1 linearly increased on 6 DPI whereas decreased on 9 DPI as Met level increased (P < 0.05). The expressions of cytokines were lower in the LCP groups than the NCP groups (P < 0.05). Interaction effects were found for the expression of IL-10 and TNFα on 6 DPI (P < 0.05), where it only changed quadratically in the NCP group as Met level increased. The expression of Met and folate metabolism genes were lower in the LCP groups than the NCP groups on 9 DPI (P < 0.05). The expression of these genes linearly or quadratically decreased as Met level increased (P < 0.05).

Conclusion
These results revealed the regulatory roles of Met in different physiological parameters including oxidative status, intestinal health, and nutrient metabolism in birds fed reduced protein diet and challenged with Eimeria.
Analysis of the biocorrosion community from ancient wooden constructions at Tianluoshan (7000–6300 cal BP), Zhejiang Province, China
Authors: Wang Biao , Zhu Chengshuai , Wang Bowen , Zhang Bingjian , Hu Yulan 
Published: June 2024

Abstract
Ancient wooden constructions, also known as wooden cultural relics, refers to ancient wood that has been modified or crafted by human activities. To ensure its preservation, it is crucial to gain further understanding of the decomposition mechanisms affecting archaeological wood. In this study, we investigated the microbiome diversity and cellulose decomposition processes in a 6300-year-old ancient wooden construction at the Tianluoshan site (7000–6300 cal BP) in Zhejiang Province, China. High-throughput sequencing (HTS) was employed to analyze the metagenomic functions, specifically focusing on the microbial communities' cellulose-degrading pathways using bioinformatic approaches. The findings revealed that the excavation of archaeological wood significantly altered the environment, leading to an accelerated deterioration process. This degradation was primarily influenced by carbohydrate metabolism and xenobiotic biodegradation and metabolism pathways within the complex ecosystem consisting of bacteria, archaea, fungi, microfauna, plants, and algae. Proteobacteria, actinobacteria, ascomycota, and basidiomycota were identified as the main sources of bacterial cellulose-degrading enzymes. The results obtained from this evaluation will provide valuable insights for the development of targeted conservation strategies and prioritization of preservation efforts for the ancient wooden constructions found in different regions of the Tianluoshan site.

Graphical Abstract
Automatic labeling framework for paint loss disease of ancient murals based on hyperspectral image classification and segmentation
Authors: Yu Kai , Hou Yucen , Fu Yihao , Ni Wenwei , Zhang Qunxi , Wang Jun , Peng Jinye 
Published: June 2024

Abstract
Ancient murals have suffered from continuous damage over time, and especially paint loss disease. Therefore, disease labeling, as the basis for ancient mural restoration, plays an important role in the protection of cultural relics. The predominant method of disease labeling is currently manual labeling, which is highly dependent on expert experience, time consuming, inefficient and results in inconsistent accuracy of the marking effect. In this paper, we propose a labeling framework for paint loss disease of ancient murals based on hyperspectral image classification and segmentation. The proposed framework involves first the extraction of features from the hyperspectral image, and then image segmentation is performed based on the spatial features to obtain more accurate region boundaries. Then, the hyperspectral image’s regions are classified based on their spatial-spectral characteristics, and the candidate areas of paint loss disease are obtained. Finally, by leveraging the true color image segmentation results, the proposed disease labeling strategy combines the results of classification and segmentation to propose the final paint loss disease labeling areas. The experimental results show that the proposed method can not only combine the hyperspectral space and spectral information effectively to obtain accurate labeling of paint loss disease, but can also mark the paint loss disease not easily observed using ordinary digital cameras. Compared with the state-of-the-art methods, the proposed framework could be promising for accurate and effective paint loss disease labeling for ancient murals.