bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic value of C‐reactive protein in parapneumonic effusions
Authors: SKOURAS VASILEIOS , BOULTADAKIS EUAGGELOS , NIKOULIS DIMITRIOS , POLYCHRONOPOULOS VLASIS , DANIIL ZOE , KALOMENIDIS IOANNIS , GOURGOULIANIS KONSTANTINOS I. 
Published: October 2011

ABSTRACTBackground and objective:  Parapneumonic effusions (PPE) that require drainage are referred to as complicated parapneumonic effusions (CPPE). Following resolution of these effusions, residual pleural thickening (RPT) may persist. We hypothesize that the concentrations of CRP in pleural fluid (CRPpf) and serum (CRPser) can be used to identify CPPE and to predict RPT.Methods:  All patients with non‐purulent PPE, who were admitted to two tertiary hospitals during a 30‐month period, were enrolled in the study. Baseline CRPpf and CRPser levels were compared between patients with complicated or uncomplicated PPE, as well as between patients with or without RPT of >10 mm, 6 months after discharge from hospital. Cut‐off values for identification of CPPE and prediction of RPT were determined by receiver operating characteristic curve analysis. Logistic regression analysis was performed to assess the association between CRP levels and RPT.Results:  Fifty‐four patients were included in the study. Patients with CPPE (n = 23) had significantly higher levels of both CRPpf and CRPser than those with uncomplicated PPE. For identification of CPPE, a CRPpf level >78.5 mg/L and a CRPser level >83 mg/L gave 84% and 47% sensitivity, with 65% and 87% specificity, respectively. Classical criteria (pleural fluid pH <7.20, LDH >1000 IU/L, glucose <600 mg/L) were superior for this purpose. A combination of classical biomarkers with CRP levels using an ‘AND’ or ‘OR’ rule improved the positive and negative predictive values, respectively. CRPser was an independent predictor for development of RPT (adjusted OR 1.18). A CRPser level >150 mg/L had 91% specificity and 61% sensitivity for prediction of RPT.Conclusions:  This study demonstrated the value of CRPser for prediction of RPT in patients with PPE. Moreover, when used in combination with classical biomarkers, CRP levels may be a useful adjunct for decision‐making in relation to treatment of patients with non‐purulent PPE.
A case of primary retroperitoneal serous adenocarcinoma
Authors: Arichi Naoko , Yasumoto Hiroaki , Mitsui Yozo , Hiraoka Takeo , Honda Satoshi , Shiina Hiroaki , Igawa Mikio 
Published: October 2011

AbstractPrimary retroperitoneal serous adenocarcinoma (PRSA) is an extremely rare malignancy, of which only six cases have been reported in the literature. Here, we describe a PRSA in a 75‐year‐old woman treated with surgical excision and adjuvant chemotherapy. The pathological features of PRSA resemble those of ovarian serous carcinoma, which suggests that a combination of surgical excision with adjuvant chemotherapy may be the best option.
Subjective Well‐being Poverty of the Elderly Population in China
Authors: Wang Xiaolin , Shang Xiaoyuan , Xu Liping 
Published: October 2011

AbstractPoverty is represented not only by objective well‐being indicators which include income and consumption levels, but also by subjective indicators which reflect what a person feels. It is estimated in this article that the incidence of subjective well‐being poverty (SWP) among the Chinese rural elderly population in 2006 was 9.7 per cent, about 4.2 times as much as that of the country's total rural population in the same year, which was 2.3 per cent. Over 16 per cent of the rural elderly population and 11.5 per cent of the urban elderly population rated their life satisfaction as poor or very poor. In terms of SWP, senior citizens, especially those who live in rural areas or who are women or very aged, have become a special group among the poor in China. This article suggests that China's social policies for the new stage take into account the issue of absolute poverty and also that of SWP. A multi‐dimensional strategy system targeting the issue of poverty needs to be established, and a policy system to address poverty reduction as well as old age security and care should be implemented.
GROOVED WARE FEASTING IN YORKSHIRE: LATE NEOLITHIC ANIMAL CONSUMPTION AT RUDSTON WOLD
Authors: ROWLEY‐CONWY PETER , OWEN ANDREW C. 
Published: October 2011

SummaryWe consider (a) feasting, and (b) the formal deposition of feasting detritus, with regard to the Late Neolithic pits on Rudston Wold. Pigs are common, as in most Grooved Ware assemblages, but we suggest that cattle may have played a proportionately greater role in eastern and northern England. Claimed ‘aurochs’ from the site are in fact misidentified domestic cattle; hardly any wild animals are present. Some aspects of the assemblage support the suggestion that the animals were consumed during feasts, although these were on a much smaller scale than those seen at major Grooved Ware monuments. There is no support for the suggestion that the pits saw formal or ‘structured’ deposition.
Using sighting records to infer extinction in three endemic Argentinean marsupial frogs
Authors: Akmentins M. S. , Pereyra L. C. , Vaira M. 
Published: October 2011

AbstractThree species of marsupial frogs of the genus Gastrotheca are at the forefront of amphibian conservation concern in Argentina. Most of the data available on these amphibian species in the country are in the form of museum collections. In this study, we use the recent rediscovery of G. gracilis to test the applicability of a series of probabilistic methods and a trend analysis to analyse the sighting records in the marsupial frog species of Argentina, and to assess the probability that G. christinani and G. chrysosticta are still extant. The results suggest that the two marsupial frog species are still extant, but probably declining. Based on these results, we suggest as a precautionary measure to raise the actual conservation status of these marsupial frog species to Critically Endangered.
Neuritogenic activity of a genipin derivative in retinal ganglion cells is mediated by retinoic acid receptor β expression through nitric oxide/S‐nitrosylation signaling
Authors: Koriyama Yoshiki , Takagi Yusuke , Chiba Kenzo , Yamazaki Matsumi , Arai Kunizo , Matsukawa Toru , Suzuki Hirokazu , Sugitani Kayo , Kagechika Hiroyuki , Kato Satoru 
Published: October 2011

J. Neurochem. (2011) 10.1111/j.1471‐4159.2011.07533.xAbstractGenipin, a herbal iridoid, is known to have both neuroprotective and neuritogenic activity in neuronal cell lines. As it is structurally similar to tetrahydrobiopterin, its activity is believed to be nitric oxide (NO)‐dependent. We previously proposed a novel neuroprotective activity of a genipin derivative, (1R)‐isoPropyloxygenipin (IPRG001), whereby it reduces oxidative stress in RGC‐5, a neuronal precursor cell line of retinal origin through protein S‐nitrosylation. In the present study, we investigated another neuritogenic property of IPRG001 in RGC‐5 cells and retinal explant culture where in we focused on the NO‐cGMP‐dependent and protein S‐nitrosylation pathways. IPRG001 stimulated neurite outgrowth in RGC‐5 cells and retinal explant culture through NO‐dependent signaling, but not NO‐dependent cGMP signaling. Neurite outgrowth with IPRG001 requires retinoic acid receptor β (RARβ) expression, which is suppressed by an RAR blocking agent and siRNA inhibition. Thereby, we hypothesized that RARβ expression is mediated by protein S‐nitrosylation. S‐nitrosylation of histone deacetylase 2 is a key mechanism in chromatin remodeling leading to transcriptional gene activation. We found a parallelism between S‐nitrosylation of histone diacetylase 2 and the induction of RARβ expression with IPRG001 treatment. The both neuroprotective and neuritogenic activities of genipin could be a new target for the regeneration of retinal ganglion cells after glaucomatous conditions.
Definition of priority areas for soil protection at a continental scale
Authors: Kibblewhite M. G. 
Published: October 2011

AbstractResources for achieving better soil protection are limited and need to be effectively targeted. Spatial variability is high for soil types and related quality and for the risk of degradation because of the threats of organic matter decline, erosion, compaction and salinization. A framework is presented for mapping priority areas for soil protection based on assessing where there is greater risk of degradation and evaluating its acceptability. A conceptual model is proposed which links anthropogenic hazards, threats and the risk of degradation with soil functions. It is recommended that a set of test areas is defined according to dominant soil types, and the probabilities of changes to soil properties relevant to soil functions are then estimated. The risk of exceeding a particular degradation threshold within these test areas can then be assessed and assigned to risk categories to provide the basis for the identification of priority areas.
Low to Moderate Alcohol Intake During Pregnancy and Risk of Psychomotor Deficits
Authors: Bay Bjørn , Støvring Henrik , Wimberley Theresa , Denny Clark H. , Mortensen Erik L. , Eriksen Hanne‐Lise F. , Kesmodel Ulrik S. 
Published: October 2011

Background:  To examine the effects of low to moderate alcohol consumption during pregnancy on child motor function at age 5.Methods:  A prospective follow‐up study of 685 women and their children sampled from the Danish National Birth Cohort based on maternal alcohol consumption during pregnancy. At 5 years of age, the children were tested with the “Movement Assessment Battery for Children” (MABC). Parental education, maternal IQ, prenatal maternal smoking, the child’s age at testing, and gender of child were considered core confounders, while the full model also controlled for prenatal maternal binge drinking episodes, age, maternal prepregnancy body mass index, parity, home environment, postnatal parental smoking, health status, and indicators for hearing and vision impairment.Results:  There were no systematic or significant differences in motor function between children of mothers reporting low to moderate levels of average alcohol consumption during pregnancy and children of mothers who abstained.Conclusions:  In this study, we found no systematic association between low to moderate maternal alcohol intake during pregnancy and child motor function at age 5.
When ShouldRD&Eand Marketing Collaborate? The Moderating Role of Exploration–Exploitation and Environmental Uncertainty
Authors: Calantone Roger , Rubera Gaia 
Published: October 2011

Collaboration between research, development, and engineering (RD&E) and marketing has traditionally been regarded as beneficial for new product performance (NPP). However, some studies have pointed out the drawbacks of excessive collaboration. Because collaboration simultaneously presents costs and benefits that vary with conditions, a contingent view of managerial practices suggests that the optimal level of integration should vary according to some factors that indicate when high levels of collaboration are preferable to lower levels. Although the literature on the many different factors that may impact the desirable level of collaboration is abundant, only a few studies have investigated the role of the peculiar characteristics of the new products being developed. This is at odds with several calls for future research on the role of the characteristics of the new product. This paper investigates the moderating role of an explorative versus an exploitive innovation program. It also controls for the moderating role of environmental uncertainty, which has been traditionally considered a moderator of the relationship betweenRD&E–marketing collaboration and new product program performance.The paper also investigates how a firm's innovation posture—a cultural trait—influences both directly and indirectly, via marketing's technical knowledge,RD&E–marketing collaboration. Indeed, several scholars have recognized that cultural differences create the main barrier betweenRD&Eand marketing. Hence, a firm's culture should have an impact on the cultural barriers between the two departments. Further, the firm's innovation posture affects the extent to which the departments have to share resources and exchange information. In their seminal work,Gupta,Raj, andWilemon argue that resource dependency is the main factor affecting the integration achieved betweenRD&Eand marketing. Hence, an analysis of a firm's innovation posture is required to gain a deeper understanding of the antecedents of the collaboration between the two departments.The antecedents and effects ofRD&E–marketing collaboration are tested in a sample of 80 companies operating in theU.S. auto industry through partial least squares. The paper shows that the extent to which a company develops explorative rather than exploitative innovations is a better moderator than environmental uncertainty in the relationship betweenRD&E–marketing collaboration and new product program performance. This contradicts much previous literature and sheds light on a partially neglected construct in the new product development literature. Second, the paper demonstrates that firms with a more aggressive innovation posture tend to develop greater collaboration betweenRD&Eand marketing. Also, the marketing department tends to have a better understanding of theRD&Eprocesses and capabilities in companies with an aggressive innovation posture than in companies with a defensive one.
Sex Differences in Characteristics of Adolescents Presenting to the Emergency Department with Acute Assault‐related Injury
Authors: Ranney Megan L. , Whiteside Lauren , Walton Maureen A. , Chermack Stephen T. , Zimmerman Marc A. , Cunningham Rebecca M. 
Published: October 2011

ACADEMIC EMERGENCY MEDICINE 2011; 18:1027–1035 © 2011 by the Society for Academic Emergency MedicineAbstractObjectives:  Adolescents with a history of peer assault are known to report high rates of other risky behaviors. The characteristics of adolescents seeking care in the ED for acute assault‐related injury are less well established. This knowledge deficit is particularly noticeable for adolescent female victims of peer assault. This study’s objectives were: 1) to characterize the demographics and risk behaviors of youths presenting to the emergency department (ED) with acute assault‐related injury and 2) to compare assaulted youths’ demographic characteristics, past experiences with violence, and other risk behaviors by sex.Methods:  A systematic sample of adolescents (ages 14 to 18 years) presenting to an urban ED with acute assault‐related injury (excluding dating violence, sexual assault, and child abuse) was recruited. Consenting participants self‐administered a computerized survey about demographics, history of peer and dating aggression, and theoretical correlates of violence (e.g., alcohol and other drug use, depressive symptoms, weapon carriage). Multivariate logistic regression was performed to identify factors that were differentially associated with presentation to the ED for acute assault‐related injury for females versus males.Results:  Of 3,338 adolescents completing a screening survey during the 36‐month study period, 197 had presented to the ED with acute assault‐related injuries; seven of these were excluded from this study due to being victims of dating violence. Most (n = 179, 94.2%) of these 190 acutely assaulted participants were discharged home. The majority reported a history of past‐year peer aggression (n = 160, 84.2%) and past‐year violent injury (n = 106, 55.8%). Similar rates of past‐year peer aggression, past‐year violent injury, alcohol use, and weapon carriage were observed for adolescent males and females presenting with acute assault‐related injury. Males and females also reported similar age, race, socioeconomic status, and education levels. Compared to males, females were less likely to report living with a parent (odds ratio [OR] = 0.25, 95% confidence interval [CI] = 0.08 to 0.84) and were more likely to report depressive symptoms (OR = 2.59, 95% CI = 1.23 to 5.48) and past‐year dating aggression (OR = 2.23, 95% CI = 1.04 to 4.82).Conclusions:  Male and female adolescents with acute assault‐related injuries were very similar. Both reported extremely high rates of past year peer violence, assault‐related injury, and substance use. The greater prevalence of some risk factors among adolescent females, such as depressive symptoms, dating aggression, and independent living status, should be further investigated.
Implication of CD38 gene in podocyte epithelial‐to‐mesenchymal transition and glomerular sclerosis
Authors: Boini Krishna M. , Xia Min , Xiong Jing , Li Caixia , Payne Lori P. , Li Pin‐Lan 
Published: October 2011

AbstractCD38 is a multifunctional protein involving in a number of signalling pathways. Given that the lack of CD38 is considered as a dedifferentiation marker of lymphocytes and other cells, we hypothesized that CD38 and its signalling pathway may participate in the epithelial‐to‐mesenchymal transition (EMT) process of podocytes and thereby regulates the integrity of glomerular structure and function. Western blot analysis and RT‐PCR demonstrated that renal tissue CD38 expression was lacking in CD38−/− mice or substantially reduced in renal CD38 shRNA‐transfected WT (CD38‐shRNA) mice compared to CD38+/+ littermates. Confocal fluorescent microscopy demonstrated the reduced expression of epithelial markers (P‐Cadherin, ZO‐1 and podocin) and increased expression of mesenchymal markers (FSP‐1, α‐SMA and desmin) in the glomeruli of CD38−/− and CD38‐shRNA mice compared to CD38+/+ mice. Morphological examinations showed profound injury in the glomeruli of CD38−/− or CD38‐shRNA mice compared to CD38+/+ mice. This enhanced glomerular injury in CD38−/− or CD38‐shRNA mice was accompanied by increased albuminuria and proteinuria. DOCA/high salt treatment further decreased the expression of epithelial markers and increased the abundance of mesenchymal markers, which were accompanied by more increased glomerular damage index and mean arterial pressure in CD38−/− and CD38‐shRNA mice than CD38+/+ mice. In vitro studies showed that inhibition of CD38 enhances the EMT in podocytes. In conclusion, our observations reveal that the normal expression of CD38 importantly contributes to the differentiation and function of podocytes and the defect of this gene expression may be a critical mechanism inducing EMT and consequently resulting in glomerular injury and sclerosis.
Preventive effects of thymoquinone in a rat periodontitis model: a morphometric and histopathological study
Authors: Ozdemir H. , Kara M. I. , Erciyas K. , Ozer H. , Ay S. 
Published: October 2011

Ozdemir H, Kara MI, Erciyas K, Ozer H, Ay S. Preventive effects of thymoquinone in a rat periodontitis model: a morphometric and histopathological study. J Periodont Res 2012; 47: 74–80. © 2011 John Wiley & Sons A/SBackground and Objective:  Thymoquinone has a variety of pharmacologic properties, including antihistaminic, antibacterial, antihypertensive, hypoglycemic, anti‐inflammatory and anti‐oxidative activities. Through its anti‐inflammatory and antioxidant properties, thymoquinone may play an important role in preventing periodontal diseases. The aim of this study was to evaluate the effectiveness of thymoquinone in preventing the initiation and progression of periodontitis in a rat periodontitis model.Material and Methods:  Twenty‐four rats were randomly divided into three experimental groups: a nonligated (NL) treatment group (n = 8), a ligature‐only (LO) treatment group (n = 8) and a ligature plus thymoquinone (10 mg/kg, daily for 11 d) (TQ) treatment group. In order to induce experimental periodontitis, a 4/0 silk suture was placed at the gingival margin of the right‐mandibular first molars of the rats. Thymoquinone was administered by gastric feeding until the animals were killed on day 11. Changes in the alveolar bone levels of rats in each group were measured clinically, and tissues of rats in each group were examined histopathologically to determine inflammatory cell infiltration (ICI), osteoblast and osteoclast activities, and osteoclast morphology.Results:  Alveolar bone loss around the mandibular molar tooth was significantly higher in the LO group compared with NL and TQ groups (p < 0.05). The ratio of the presence of ICI and osteoclast numbers was significantly higher in the LO group than in the NL and TQ groups (p < 0.05). Osteoblastic activity was significantly lower in the LO group than in the NL and TQ groups (p < 0.05).Conclusion:  The present study showed that the oral administration of thymoquinone diminishes alveolar bone resorption in a rat periodontitis model.
The Nucleoporin Nup358/RanBP2 Promotes Nuclear Import in a Cargo‐ and Transport Receptor‐Specific Manner
Authors: Wälde Sarah , Thakar Ketan , Hutten Saskia , Spillner Christiane , Nath Annegret , Rothbauer Ulrich , Wiemann Stefan , Kehlenbach Ralph H. 
Published: October 2011

AbstractIn vertebrates, the nuclear pore complex (NPC), the gate for transport of macromolecules between the nucleus and the cytoplasm, consists of approximately 30 different nucleoporins (Nups). The Nup and SUMO E3‐ligase Nup358/RanBP2 are the major components of the cytoplasmic filaments of the NPC. In this study, we perform a structure–function analysis of Nup358 and describe its role in nuclear import of specific proteins. In a screen for nuclear proteins that accumulate in the cytoplasm upon Nup358 depletion, we identified proteins that were able to interact with Nup358 in a receptor‐independent manner. These included the importin α/β‐cargo DBC‐1 (deleted in breast cancer 1) and DMAP‐1 (DNA methyltransferase 1 associated protein 1). Strikingly, a short N‐terminal fragment of Nup358 was sufficient to promote import of DBC‐1, whereas DMAP‐1 required a larger portion of Nup358 for stimulated import. Neither the interaction of RanGAP with Nup358 nor its SUMO‐E3 ligase activity was required for nuclear import of all tested cargos. Together, Nup358 functions as a cargo‐ and receptor‐specific assembly platform, increasing the efficiency of nuclear import of proteins through various mechanisms.
Circulating Cell‐Derived Microparticles in Severe Preeclampsia and in Fetal Growth Restriction
Authors: Alijotas‐Reig Jaume , Palacio‐Garcia Carles , Farran‐Codina Immaculada , Ruiz‐Romance Mar , Llurba Elisa , Vilardell‐Tarres Miquel 
Published: October 2011

Citation Alijotas‐Reig J, Palacio‐Garcia C, Farran‐Codina I, Ruiz‐Romance M, Llurba E, Vilardell‐Tarres M. Circulating cell‐derived microparticles in severe preeclampsia and in fetal growth restriction. Am J Reprod Immunol 2012; 67: 140–151Problem  The behavior of the circulating microparticles (cMP) in severe preeclampsia (PE) and fetal growth restriction (FGR) is disputed.Method of study  Non‐matched case–control study. Seventy cases of severe PE/HELLP/FGR were compared to 38 healthy pregnant women. Twenty healthy non‐pregnant women acted as a control. cMP were analyzed using flow cytometry. Results are given as total (annexin‐A5‐ANXA5+), platelet (CD41+), leukocyte (CD45+), endothelial (CD144+CD31+//CD41−), and CD41‐negative cMP/μL of plasma. Antiphospholipid antibodies (aPL) were analyzed through usual methods.Results  Platelet and endothelial cMP increased in healthy pregnant women. PE whole group (PE ± FGR) showed an increase in endothelial and CD41‐negative, but not in platelet‐derived, cMP. Comparing PE whole group versus healthy pregnant, we found cMP levels of endothelial and CD41− had increased. The cMP results obtained in PE group were similar to those of the PE whole group. Comparing PE group to isolated FGR, significant CD41‐negative cMP increase was found in PE. According to its aPL positivity, a trend to decrease in leukocyte and endothelial‐derived cMP was found in PE group.Conclusion  Normal pregnancy is accompanied by endothelial and platelet cell activation. Endothelial cell activation has been shown in PE but not in isolated FGR. In PE, aPL may contribute to endothelial and possibly to leukocyte cell activation.