bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selective nonoperative versus operative management of liver gunshot injuries: a retrospective cohort study
Authors: Dalcin RR , Petrillo YTM , Alves LAC , Fonseca MK , Almeida AS , Corso CO 
Published: May 2024

Introduction Experience accumulated over the last decades suggests nonoperative management (NOM) of civilian gunshot liver injuries can be safely applied in selected cases. This study aims to compare the outcomes of selective NOM versus operative management (OM) of patients sustaining gunshot wounds (GSW) to the liver. Methods A registry-based retrospective cohort analysis was performed for the period of 2008 to 2016 in a Brazilian trauma referral. Patients aged 16–80 years sustaining civilian GSW to right-sided abdominal quadrants and liver injury were included. Baseline data, vital signs, grade of liver injury, associated injuries, injury severity scores, blood transfusion requirements, liver- and non-liver-related complications, length-of-stay (LOS), and mortality were retrieved from individual registries. Results A total of 54 patients were eligible for analysis, of which 37 underwent NOM and 17 underwent OM. The median age was 25 years and all were male. No statistically significant differences were observed between groups regarding patients’ demographics, injury scores, grade of liver injury and associated lesions. NOM patients tended to sustain higher-grade injuries (86.5% vs 64.7%; p = 0.08), and failure of conservative management was recorded in two (5.4%) cases. The rate of complications was 48% with no between-group statistically significant difference. Blood transfusion requirements were significantly higher in the OM group (58.8% vs 21.6%; p = 0.012). The median LOS was seven days. No deaths were recorded. Conclusion Patients with liver GSW who are haemodynamically stable and without peritonitis are candidates for NOM. In this study, NOM was safe and effective even in high-grade injuries.
Impact of untreated preoperative asymptomatic bacteriuria in patients undergoing holmium laser enucleation of prostate
Authors: Bheenick D , Conroy M , Bondad J , Dawam D , Young T , Acher P 
Published: May 2024

Introduction Treatment of preoperative asymptomatic bacteriuria (ASB) before endoscopic surgery is recommended by European Association of Urology (EAU) guidelines. United Kingdom (UK) practice varies, however, owing to the historical nature of the evidence behind the guidelines, risk of increased antimicrobial resistance, the paradoxical view that treatment of ASB leads to increased infection and inefficiencies in rescheduling. We do not routinely treat ASB in our practice before holmium enucleation of the prostate (HoLEP). To determine the safety of this, we examined our experience focusing on the infective complications. Methods Retrospective data collection was performed on consecutive patients undergoing HoLEP between 2015 and 2020. Indication, preoperative urine cultures and infective complications were recorded. No patients were pretreated with oral antibiotics. All patients received intravenous antibiotics on induction and routine postoperative oral antibiotics at the surgeon's discretion. Results Some 443 patients were studied. No urosepsis occurred in the 125 patients with ASB compared with 2 of 318 patients (0.6%) with no growth on preoperative urine culture. Twenty-nine (7%) patients were treated with oral antibiotics for symptomatic postoperative complications (urinary tract infection without fever, epididymitis and haematuria). ASB did not predict for infective complications (urosepsis odds ratio [OR]: 0.50 p=0.66; oral antibiotics OR: 0.97 p=0.93). Conclusion Not treating ASB before a HoLEP procedure is safe. This supports the judicious use of antimicrobials preoperatively. Other modalities of endoscopic surgery should be similarly assessed.
Trainee as trainer in paediatric laparoscopic appendicectomy
Authors: Henderson L , Patwardhan N , Dagash H 
Published: May 2024

Background Intraoperative teaching is an essential surgical skill, but there is little literature regarding trainees acting as trainers; we characterised these cases in paediatric laparoscopic appendicectomy. Methods This is a retrospective review of casenotes over two years (2015–2017) in a single tertiary paediatric surgical centre in the UK. Operating were: paediatric surgery Core Trainees (CT) (postgraduate year (PGY)3–4), Junior Registrars (JR) (PGY5–6) and Senior Registrars (SR) (PGY7+); collectively described as trainees. Results A total of 53 (20.7%) of 256 appendicectomies were trainee as trainer (TT) cases; 22 cases (41.5%) were performed by a CT supervised by a Registrar, and 31 (58.4%) by a JR supervised by a SR. Among the cases, 17 (32.1%) were complex, 47 (88.7%) were in working hours (8am–5pm), and 50 (94.3%) took place Monday to Friday. Median (interquartile range) duration of surgery was 65 (52–77) minutes. In the first year, 60 (47%) appendicectomies were performed by JRs. JR 1 was TT in three cases (8.8%) and JR 2 in five cases (19.2%); in all cases, the learner was a CT. Overall, there were 26 (10.6%) negative appendicectomies, 8 (3%) conversions, 19 (7%) readmissions within 30 days of discharge and 3 (1.1%) required reoperation; there was no statistically significant difference in complications between TT and non-TT cases. Conclusion Laparoscopic appendicectomy is an excellent model for trainees to act as trainer; case selection included simple cases during daylight hours. Our outcomes are comparable with published literature, suggesting that this teaching method is safe for patients.
Switchable dual ultra-broadband perfect absorber based on graphene and vanadium dioxide hybrid metamaterials
Authors: Zhuo Shanshan 
Published: May 2024

The phase transition property of vanadium dioxide (VO2) makes it an attractive field in temperature-controlled chips. In this paper, a microstructure based on a graphene disk and a ring-shaped VO2 hybrid metamaterial is proposed to achieve switchable dual ultra-broadband perfect absorption in the terahertz region, which is analyzed by the phase transition property of VO2 and the dynamic electrical regulation of graphene. When the graphene disk is not present, the absorption intensity can reach up to 97.07%. When the graphene disk is present and respectively interacts with the VO2 metallic and insulated phases, the results exhibit an ultra-broadband perfect absorption (>90%) from 1.620 THz to 4.533 THz and from 1.506 THz to 3.576 THz, respectively, where the bandwidths are as high as 2.913 THz and 2.070 THz, respectively. Adjusting the Fermi level of graphene and the VO2 conductivity allows the absorption intensity and bandwidth to be effectively controlled, where the fractional bandwidth from 81.46% to 94.69% and a high modulation depth of 95.09% can be achieved. These results suggest that dual ultra-broad perfect absorption can be dynamically switched within a single absorber and has various modulation means, which are expected to be developed in applying multifunctional modulators.
The incidence of thrombosis with co-occurring thrombocytopenia prior to the SARS-CoV2 pandemic: A population-based study
Authors: Liu Yanfang , Goh Choo-Hua , Shen Dereck , Qiu Hong , Huang Kuan-Chih , Luo Man , Chen Zhangjing , Tang Chao-Hsiun 
Published: May 2024

Background
Thrombosis with thrombocytopenia syndrome (TTS) is a very rare prothrombotic disorder that is a safety concern for some COVID-19 vaccines. We aimed to devise a case definition to estimate the incidence of thrombosis with thrombocytopenia as a proxy for TTS in a national insurance claims database.

Methods
We conducted a retrospective observational study using the National Health Insurance Research Database (NHIRD) in Taiwan over the three-year period prior to the SARS-COV-2 pandemic (2017–2019). Our case definition was all patients with newly diagnosed thrombosis co-occurring with a diagnosis of thrombocytopenia within seven days before or after the thrombosis diagnosis. Cases were identified using International Classification of Disease-10 codes.

Findings
We identified 2010 patients with newly diagnosed thrombosis co-occurring with thrombocytopenia during the study period. The mean age was 64.71 years; female:male ratio 1:1.45. The most frequent thrombotic events were coronary artery disease (18.81%), cerebral infarction (16.87%), and disseminated intravascular coagulation (13.13%). Cerebral venous sinus thrombosis was rare (<0.1%). The average annual incidence rate of co-occurring new diagnoses of thrombosis and thrombocytopenia was 2.84 per 100 000 population. Incidence rates were higher in men than women, except in 20–39 year-olds (higher in females). 20.6% of patients died within the first month after diagnosis.

Interpretation
We observed that the demographic and clinical characteristics of thrombosis with co-occurring thrombocytopenia using our case definition is different from that of TTS. Further research is needed to refine the case definition of TTS in the post-COVID-19 vaccination period.
Serotype epidemiology and antibiotic resistance of pneumococcal isolates colonizing infants in Botswana (2016–2019)
Authors: Hurst Jillian H. , Shaik-Dasthagirisaheb Yazdani B. , Truong Loc , Boiditswe Sefelani C. , Patel Sweta M. , Gilchrist Jodi , Maciejewski Julia , Luinstra Kathy , Smieja Marek , Steenhoff Andrew P. , Cunningham Coleen K. , Pelton Stephen I. , Kelly Matthew S. 
Published: May 2024

Background
In 2012, Botswana introduced 13-valent pneumococcal conjugate vaccine (PCV-13) to its childhood immunization program in a 3+0 schedule, achieving coverage rates of above 90% by 2014. In other settings, PCV introduction has been followed by an increase in carriage or disease caused by non-vaccine serotypes, including some serotypes with a high prevalence of antibiotic resistance.

Methods
We characterized the serotype epidemiology and antibiotic resistance of pneumococcal isolates cultured from nasopharyngeal samples collected from infants (≤12 months) in southeastern Botswana between 2016 and 2019. Capsular serotyping was performed using the Quellung reaction. E-tests were used to determine minimum inhibitory concentrations for common antibiotics.

Results
We cultured 264 pneumococcal isolates from samples collected from 150 infants. At the time of sample collection, 81% of infants had received at least one dose of PCV-13 and 53% had completed the three-dose series. PCV-13 serotypes accounted for 27% of isolates, with the most prevalent vaccine serotypes being 19F (n = 20, 8%), 19A (n = 16, 6%), and 6A (n = 10, 4%). The most frequently identified non-vaccine serotypes were 23B (n = 29, 11%), 21 (n = 12, 5%), and 16F (n = 11, 4%). Only three (1%) pneumococcal isolates were resistant to amoxicillin; however, we observed an increasing prevalence of penicillin resistance using the meningitis breakpoint (2016: 41%, 2019: 71%; Cochran-Armitage test for trend, p = 0.0003) and non-susceptibility to trimethoprim-sulfamethoxazole (2016: 55%, 2019: 79%; p = 0.04). Three (1%) isolates were multi-drug resistant.

Conclusions
PCV-13 serotypes accounted for a substantial proportion of isolates colonizing infants in Botswana during a four-year period starting four years after vaccine introduction. A low prevalence of amoxicillin resistance supports its continued use as the first-line agent for non-meningeal pneumococcal infections. The observed increase in penicillin resistance at the meningitis breakpoint and the low prevalence of resistance to ceftriaxone supports use of third-generation cephalosporins for empirical treatment of suspected bacterial meningitis.
Job burnout, cognitive functioning, and Brain-derived neurotrophic factor expression among hospital Mexican nurses
Authors: Cortés-Álvarez Nadia Yanet , Lara-Morales Alfredo , Bautista-Rodríguez Elizabeth , Marmolejo-Murillo Leticia Gabriela , Díaz Jiménez Alejandra , Vergara Hernández Lourdes Alejandra , Fernández Moya Monserrat , Vuelvas-Olmos César Rubén 
Published: May 2024

Aim
To analyze the relationship between burnout syndrome, cognitive functions, and sBDNF (Serum Brain-derived Neurotrophic Factor) in Mexican nurses.

Method
A descriptive cross-sectional design was used. This study target staff nurses working in hospitals in Guanajuato, México. Demographic and working condition data were collected via questionnaire. The Maslach Burnout Inventory (MBI) was used to evaluate burnout. A blood sample were collected and processed by ELISA technique to measure sBDNF. Finally, the General Cognitive Assessment (CAB) of the Cognifit© neuropsychological battery was used to evaluated cognitive functions.

Results
Findings showed that there are sociodemographic characteristics and working conditions associated with burnout syndrome among nurses. Furthermore, the data demonstrated a significant decrease in sBDNF levels in burnout nurses and a negative correlation between BDNF levels and burnout syndrome. Additionally, these burnout nurse also revealed significant cognitive impairment in reasoning, memory, and attention as well as total scores of CAB. Interestingly, we found a positive correlation between sBDNF levels and the cognitive deficits in burnout nurse.

Conclusion
Reduced BDNF levels could be a biological indicator or part of the pathological process of burnout, which could affect cognitive abilities. Reduced cognitive function in nurses has relevant implications and emphasizes the need for specialized preventive strategies because nurses make clinical decisions concerning their patients, whose situations are constantly changing.
The All4Children project to assess the initial implementation of the Integrated Model of Family Foster Care in Portugal: A description of the study protocol
Authors: Baptista Joana , Grangeia Helena , Negrão Mariana , Camilo Cláudia , Ornelas Sandra , Nogueira Sandra , Pastor Isabel , Gaspar Ana , Soares Isabel , Alves Stephanie 
Published: May 2024

Background
The All4Children project addresses the urgent need to transition from institutionalization to family-based care for out-of-home children in Portugal. Despite evidence highlighting the detrimental effects of institutionalization, only a small percentage of children (less than 4%) are currently placed in family foster care in the country. In response to European directives for deinstitutionalization, Portuguese legislation now prioritizes non-kinship family foster care as the preferred alternative for young children in need of care. To facilitate this transition, the Integrated Model of Family Foster Care (MIAF) was developed, offering a comprehensive framework covering the entire spectrum of family foster care.

Objective
This research aims to investigate the initial implementation stage of the MIAF to promote high-quality family foster care in Portugal.

Method
The study will conduct a mixed-method and longitudinal research project in family foster care agencies across different regions of Portugal, focusing on evaluating the implementation and outcomes of the MIAF model using a multi-informant and multi-method approach. The participants will include caseworkers, children aged 0–9 years entering foster care, and their respective foster families enrolled in the MIAF program. Process evaluation will assess fidelity, feasibility, appropriateness, and acceptability of MIAF modules, while outcome evaluation will examine child safety, stability, well-being, as well as foster family well-being and quality of relational care.

Outcomes
The insights gained from this research initiative will serve as a foundation for the ongoing enhancement of MIAF. Consequently, this project has the capacity to advance evidence-based child welfare practices by refining processes and strategies to better serve vulnerable children and youth.

Conclusion
Facilitated by a multidisciplinary team, this project will contribute to advancing research in the field, enhancing practice, and informing policy during a pivotal stage of deinstitutionalization in Portugal.
Los Condenados de la Tierra: Un film entre Europa y el Tercer Mundo, Alberto Filippi and Mariano Mestman (2022)
Authors: Peretti Luca 
Published: May 2024

Review of: Los Condenados de la Tierra: Un film entre Europa y el Tercer Mundo, Alberto Filippi and Mariano Mestman (2022)
Buenos Aires: Ediciones Akal, 509 pp.,
ISBN 978-9-87836-739-2, p/bk, e-book, €7.99
Elastic deformation analysis of rotational wood-dowel welding joint system based on the variational method
Authors: Xu Yun , Wang Xuejiao 
Published: May 2024

Abstract
This study aimed to investigate the elastic deformation of rotational wood-dowel welding joints by using the variational method, as there was no efficient tool to access the deformation behavior of welding joints perpendicular to axis orientation so far. Based on the variational method, the displacement control equation of axially-loaded dowel-welded wood joints was derived. By incorporating the boundary conditions and using an iterative approach, the parameters required in the control equation were determined. The analytical expression ϕ(r) for the deformation function of the wood substrate under elastic conditions was proposed, thereby determining the displacement and axial force of the single wood-dowel. The elasticity modulus was the primary influence parameter on the function ϕ(r). However, the welding depth had a more critical impact, and reasonable combination of parameters could lead to a better interaction between the wood dowel and substrate. The comparison between calculated results and test trials collected from the previous studies indicated that the elastic solution method could accurately estimate the pull-out ultimate bearing capacity and deformation characteristics of the welding joints. This work can provide unique perspective to understand the technology of rotational wood-dowel welding joints, and a good reference suggestion for the manufacture of multi-dowel welding joints.
The crystal structure of 2,3,9-triphenyl-9-(2-phenylbenzofuran-3-yl)-9H-9λ
5-benzo[4,5][1,2]oxaphospholo[2,3-b][1,2,5]oxadiphosphole 2-oxide, C40H28O4P2
Authors: Sun Longgen , Mei Zhichao , Chen Chao , Huang Haiyang , Kong Fangfang , Bai Jiang 
Published: May 2024

Abstract
C40H28O4P2, monoclinic, P21/c (no. 4), a = 10.651(3) Å, b = 16.702(5) Å, c = 11.352(4) Å, β = 112.985(5)°, V = 1859.1(10) Å3, Z = 2, Rgt
(F) = 0.0807, wRref
(F
2) = 0.2281, T = 296 K.
Crystal structure of poly[(μ
2-5-hydroxyisophthalato-κ4
O,O′:O″,O‴)-(μ
2-1,4-bis(2-methylimidazolyl)-1-butene-N:N′)nickel(II)], C20H20NiN4O5
Authors: Xin-Tong Yao , Jin Cai , Man-Sheng Chen 
Published: May 2024

Abstract
C20H20NiN4O5, monoclinic, P21/n (no. 14), a = 8.8571(7) Å, b = 20.4827(14) Å, c = 10.9374(8) Å, β = 101.235(3)°, V = 1946.2(2) Å3, Z = 4, Rgt
(F) = 0.0697, wRref
(F
2) = 0.1486, T = 193(2) K.
Applications of nanomedicine-integrated phototherapeutic agents in cancer theranostics: A comprehensive review of the current state of research
Authors: Shoaib Ambreen , Javed Shamama , Tabish Mohammad , Khan Mohammad Ehtisham , Zaki Mehvash , Alqahtani Saad S. , Sultan Muhammad H. , Ahsan Waquar , Afzal Mohd 
Published: May 2024

Abstract
Innovative approaches such as photodynamic therapy (PDT) and photothermal therapy (PTT) have made nanomedicines a promising frontier in cancer theranostics. The combination of nanocarriers with photothermal agents and photosensitizers (PSs) has shown excellent promise for the diagnosis and the treatment of cancer, primarily at the cellular, vascular, and tumor microenvironment level. Using nanocarriers in PDT has revolutionized precision and efficacy, allowing the drug to reach cancer cells faster and offering high enhancing PS accumulation. These agents are activated by light of specific wavelengths, leading to localized cytotoxicity, offering highly selective cancer therapy. Nanomaterials such as gold and silver nanoparticles have enabled remarkable progress in cancer hyperthermia using PTT. The unique optical properties of these nanoparticle-based nanomedicines make them ideal candidates for converting light energy into heat, selectively ablating the cancer cells. In this review, nanomedicine-integrated phototherapeutic agents are discussed and the most important recent developments in PDT and PTT are examined, as well as how nanoparticle-based formulations improve diagnosis and treatment. In addition, nanocarriers used in cancer phototherapy and their mode of action are discussed. Nanocarriers are useful for drug delivery as well as for imaging and diagnostic purposes during cancer treatment. In this review, we explore the role of nanoparticles in improving phototherapy precision and selectivity while minimizing collateral tissue damage. It specifies a comprehensive impression of the current research on cancer therapy, underscoring its potential to revolutionize the treatment paradigm by highlighting the current state of research.
Single-cell RNA-binding protein pattern-mediated molecular subtypes depict the hallmarks of the tumor microenvironment in bladder urothelial carcinoma
Authors: Zhang Jun , He Jiejie , Chen Wen , Chen Guojun , Wang Liang , Liu Yuchan , Wang Zhanjin , Yang Ming , Huang Guoyi , Yang Yongli , Ma Wei , Li Yan 
Published: May 2024

Abstract

Objectives
Bladder carcinoma (BC) is a common malignancy of the urinary tract. As a new hallmark of cancer for drug therapy, RNA-binding proteins (RBPs) are key regulatory factors in alternative splicing events. This work is to uncover the relationship between BC and RBP in order to find drug targets in BC.

Methods
In this work, data from single-cell RNA-seq GSE1355337, PRJNA662018, and the TCGA-Bladder urothelial carcinoma (BLCA) cohorts are integrated to identify their relationships. A scoring system is constructed according to RBPs gene expression and patients’ survival. A network is constructed to analyze the alternative splicing events and RBP genes.

Results
A scoring system identified 321 RBPs significantly associated with the prognosis of patients. Subsequent typing of these RBP genes in two single-cell datasets demonstrated that most of the RBP genes had variable copy numbers. Three RBP clusters were identified. Using RBP genes as a signature in BC epithelial cells allows for differentiation between different grades of BC samples. The novel RBP genes-based subtype system reflects BC clinical staging. Notably, CellChat analysis revealed that the RBP genes-associated cell subtypes of T cells had extensive interactions with epithelial cells. Further analysis showed that the ligand-receptor pair MIF-CXCR4 mediated the communication between RBP-associated subtypes of BC epithelial cells and T cells.

Conclusions
Taken together, RBP genes are associated with BC progress and offer new indicators for precision medicine in BC.
Eine Titeldivergenz in den Grabräuberpapyri
Authors: Böhm Billy 
Published: May 2024

Summary
In papyrus Amherst 6 + Léopold II (16th regnal year of Ramesses IX) of the so-called Tomb Robbery Papyri, a certain Amenemheb is mentioned three times among a number of other individuals. He was convicted of robbing the tombs of western Thebes. In this context, the titles attributed to him on the papyrus are of particular interest. In 2:2 and 3:13, he is referred to as “cultivator of the temple of Amenope” (ꜥḥ.wtj n(.j) pr Jmn-jp.t), whereas, in 4:6 he is called “agent of the temple of Amenope” (rwḏ.w Jmn-m-ḥb n(.j) pr Jmn-jp.t). Based on a detailed analysis of the contents of Papyrus Amherst 6 + Léopold II, this article demonstrates that the reason for this difference is ouster. This means that Amenemheb at least formally lost his office – unlike his colleagues. Afterwards, he was sentenced to death, which is not mentioned explicitly in the text but which we may assume with some certainty. If this is correct, this is one of the few examples of ouster as a punishment being carried out in reality. However, it was not targeted primarily at the denial of the delinquent’s access to the assets, which were tied to it.