bluuebunny/crossref_metadata_2025_split huggingface dataset:
Color Point Tuning in Lu3−x−yMnxAl5−xSixO12:yCe3+ for White LEDs
Authors: Jia Yongchao , Guo Ning , Zheng Yuhua , Qiao Hui , Lv Wenzhen , Zhao Qi , You Hongpeng 
Published: July 2012

AbstractA series of the solid‐solution phosphors Lu3−x−yMnxAl5−xSixO12:yCe3+ is synthesized by solid‐state reaction. The obtained phosphors possess the garnet structure and exhibit similar excitation properties as the phosphor Lu3Al5O12:Ce3+, but with an effectively improved red component in the emission spectrum. This can be attributed to the energy transfer from Ce3+ to Mn2+. Our investigation reveals that electric dipole–quadrupole interactions dominate the energy‐transfer mechanism and that the critical distance determined by the spectral overlap method is about 9.21 Å. The color‐tunable emissions of the Lu3−x−yMnxAl5−xSixO12:yCe3+ phosphor as a function of Mn3Al2Si3O12 content are realized by continuously shifting the chromaticity coordinates from (0.354, 0.570) to (0.462, 0.494). They indicate that the obtained material may have potential application as a blue radiation‐converting phosphor for white LEDs with high‐quality white light.
Enzymatic Reaction in Droplets Manipulated with Liquid Dielectrophoresis
Authors: Kumemura Momoko , Collard Dominique , Yoshizawa Satoko , Wee Bernard , Takeuchi Shoji , Fujita Hiroyuki 
Published: July 2012

AbstractDroplet generation and transportation for biological reactions are conducted with liquid dielectrophoresis (LDEP), forming two hundred picoliter droplets and aligning them in an open environment above the micro‐machined electrodes. The generation of the dielectrophoresis signals was critically examined to actuate droplets in biological solutions without excessive Joule heating. Enzymatic reactions between β‐galactosidase and fluorescein di‐β‐D‐galactopyranoside were succeeded in manipulated droplets, which was confirmed by fluorescence imaging. These results allow us to propose the integration of LDEP actuation in high throughput biomolecular assays.
Pore Length Effect on Drug Uptake and Delivery by Mesoporous Silicas
Authors: Burguete Pedro , Beltrán Aurelio , Guillem Carmen , Latorre Julio , Pérez‐Pla Francisco , Beltrán Daniel , Amorós Pedro 
Published: July 2012

AbstractThe capability of UVM‐7 silicas to work as supports for drug storage and delivery is investigated using ibuprofen as a model. UVM‐7 silicas are surfactant‐assisted synthesised mesoporous materials displaying a characteristic bimodal pore architecture related to their nanoparticulate texture. Strict control of the drug‐charge protocol allows the achievement of high ibuprofen loads, not only because of the availability of intra‐nanoparticle mesopores and large textural voids, but also owing to the decrease in pore‐blocking effects (with regard to related unimodal mesoporous materials such as MCM‐41) achieved through the shortening of the mesopore length. The UVM‐7/ibuprofen nanocomposites are characterised using XRD, TEM and N2 adsorption/desorption isotherms, and the drug‐delivery processes are monitored by spectrometric techniques. The bimodal porosity results in two‐stage drug‐delivery processes, which are analysed through kinetic models.
Cationic Iridium Complexes Coordinated with Coumarin Dyes – Sensitizers for Visible‐Light‐Driven Hydrogen Generation
Authors: Takizawa Shin‐ya , Pérez‐Bolívar César , Anzenbacher Pavel , Murata Shigeru 
Published: July 2012

AbstractCationic iridium(III) complexes comprising two cyclometalating 3‐(2‐benzothiazolyl)‐7‐(diethylamino)coumarin (Coumarin 6) ligands and one diimine ancillary ligand (N N) were prepared [N N = 2,2′‐bipyridyl (2), 1,10‐phenanthroline (3), 2,2′‐biquinoline (4)] and examined for their photophysical properties. The synergic effect of the intraligand charge‐transfer (ILCT) transition in the chromophoric Coumarin 6 moiety and the metal‐ligand‐to‐ligand CT (MLLCT) and/or ligand‐to‐ligand CT (LLCT) transitions associated with the diimine ligand rendered these complexes strongly absorptive in the visible region. Their enhanced absorptivity is significant when compared to the corresponding electroneutral complex 1 with acetylacetonate. Specifically, the molar extinction coefficient of complex 2 reached 129000 M–1 cm–1 at 483 nm, which is an unprecedentedly high value relative to those of other recently reported Ir‐based dyes. Ir sensitizers 2–4 were tested for visible‐light‐driven hydrogen generation by using an Ir–Co photocatalytic system, where triethylamine and tris(2,2′‐bipyridyl)dichloridocobalt were employed as a sacrificial electron donor and a water‐reduction catalyst, respectively. As a result, complexes 2 and 3 were found to be highly effective sensitizers displaying turnover numbers up to 1500.
First Intramolecular Alkylation of Nitriles with Primary and Secondary Alcohols Catalyzed by Iridium Complexes
Authors: Anxionnat Bruno , Gomez Pardo Domingo , Ricci Gino , Cossy Janine 
Published: July 2012

AbstractThe first iridium‐catalyzed intramolecular alkylation ofnitriles with primary and secondary alcohols through hydrogen transfer is described. This reaction allows access to precursors of biologically active arylmethylamines.
Fire performance and thermal stability of polypropylene nanocomposites containing organic phosphinate and ammonium polyphosphate additives
Authors: Dahiya Jai Bhagwan , Kumar Narender , Bockhorn Henning 
Published: July 2012

SUMMARYIn order to develop polymer‐clay nanocomposites with reduced flammability by incorporation of char‐forming conventional nitrogen and phosphorus based flame retardants at low loading levels, the polypropylene‐clay nanocomposites were prepared by melt blending method with Cloisite 15A (15A), organic phosphinate (OP) and ammonium polyphosphate (AP) additives. Thermal analysis shows that addition of 5% 15A along with 15% (w/w) OP in polypropylene (PP)/PPgMA increases the thermal stability of PP/PPgMA/OP/15A composite by 82 °C showing synergistic effect, and the PP/PPgMA/AP/15A sample with same loading becomes thermally stable by 70 °C. Cone calorimeter analysis of the PP/PPgMA/OP/15A and PP/PPgMA/AP/15A composites measures the reduction in peak heat release rate values by 66% and 58%, respectively. Addition of 20% OP to PP/PPgMA enhances the limiting oxygen index (LOI) value and gives V‐2 rating of UL‐94 test. Further, on replacing 5% OP with 5% 15A for PP/PPgMA/OP/15A sample without changing the total 20% loading, the LOI value increases further slightly but give no UL‐94 rating. Also, PP/PPgMA/AP/15A sample with same loading similar to that of PP/PPgMA/OP/15A sample shows an enhancement in LOI value and gives no rating in UL‐94 test. No relation was observed between LOI values and UL‐94 test rating in the present study. Copyright © 2012 John Wiley & Sons, Ltd.
An algebraic variational multiscale–multigrid method for large‐eddy simulation of turbulent pulsatile flows in complex geometries with detailed insight into pulmonary airway flow
Authors: Comerford A. , Gravemeier V. , Wall W. A. 
Published: July 2012

SUMMARYThe algebraic variational multiscale–multigrid method, an advanced computational approach recently proposed for large‐eddy simulation of turbulent flow, is further developed in this study for turbulent flow simulations in complex geometries. In particular, it is applied to the complex case of pulsatile turbulent flow dynamics of the upper and lower pulmonary airways up to generation 7 and carefully investigated for this important application. Among other things, the results obtained with the proposed method are compared with the results obtained with a rather traditional stabilized finite element method. As opposed to previous large‐eddy simulations of pulmonary airways, we consider a pulsatile inflow condition, allowing the development of turbulence over a pulse cycle to be investigated, which obviously makes these results more physiologically realistic. Our results suggest that turbulent effects in the bronchial airways are rather weak and can completely decay as early as the third generation, depending on geometry and flow distribution. Both methods utilized in this study are able to adequately capture all flow stages from laminar via transitional to turbulent regimes without any modifications. However, the algebraic variational multiscale–multigrid method provides superior results as soon as the flow enters the most challenging, turbulent flow regime. Furthermore, the robustness of the scale‐separation approach based on plain aggregation algebraic multigrid inherent to the algebraic variational multiscale–multigrid method is demonstrated for the present complex geometry. Copyright © 2012 John Wiley & Sons, Ltd.
Shattered and stitched chromosomes—chromothripsis and chromoanasynthesis—manifestations of a new chromosome crisis?
Authors: Righolt Christiaan , Mai Sabine 
Published: July 2012

AbstractChromothripsis (chromosome shattering) has been described as complex rearrangements affecting single chromosome(s) in one catastrophic event. The chromosomes would be “shattered” and “stitched together” during this event. This phenomenon is proposed to constitute the basis for complex chromosomal rearrangements seen in 2‐3% of all cancers and in ∼ 25% of bone cancers. Here we discuss chromothripsis, the use of this term and the evidence presented to support a single catastrophic event that remodels the genome in one step. We discuss why care should be taken in using the term chromothripsis and what evidence is lacking to support its use while describing complex rearrangements. © 2012 Wiley Periodicals, Inc.
Late complications and long‐term quality of life for survivors (>5 years) with history of head and neck cancer
Authors: Payakachat Nalin , Ounpraseuth Songthip , Suen James Y. 
Published: July 2012

AbstractBackgroundQuality of life (QOL) outcomes become critical for survivors of head and neck cancer. Most QOL studies were based on <5‐year outcomes and very few addressed >5‐year outcomes. This study focused late complications and >5‐year outcomes and also compared the 2 standard treatments.MethodsThe long‐term problems were identified through mail surveys. The 2 treatment arms were compared for differences.ResultsSeventy‐three of 234 possible survivors were identified as still living. Forty‐seven returned responses were analyzed to determined problems and QOL. Fifty‐three percent reported delayed complications which occurred after 5 years. When the 2 treatments were compared, no statistically significant differences were noted. The survivors in the chemoradiotherapy (CRT) group reported greater difficulties with swallowing, sticky saliva, feeding tube, and weight gain. The survivors in the surgery and postoperative radiation therapy (SRT) group reported more problems with trismus.ConclusionSome complications do not occur until after 5 years. The CRT group tended to have more problems. Head Neck, 2012
Search for chromosome rearrangements: New approaches toward discovery of novel translocations in head and neck squamous cell carcinoma
Authors: Wang Vivian W. , Laborde Rebecca R. , Asmann Yan W. , Li Yang , Ma Jian , Eckloff Bruce W. , Tombers Nicole M. , Olsen Steven M. , Moore Eric J. , Olsen Kerry D. , Smith David I. 
Published: July 2012

AbstractBackgroundChromosome rearrangements that result in gene fusions have important roles in the initial steps of tumorigenesis, especially in leukemias and lymphomas, but the biological and clinical impact of gene fusions in common solid tumors are less understood. The purpose of this study was to discover novel translocations that could result in gene fusions in oropharyngeal squamous cell carcinomas (OPSCCs).MethodsTranslocations were identified using 2 different bioinformatics pipelines, SnowShoes‐FTD and FusionHunter, examining data from 11 paired‐end RNA sequencing (RNA‐Seq) data in OPSCC. Translocations were validated by RT‐PCR and Sanger sequencing analysis.ResultsTwo novel cancer‐specific translocations involving MGST3‐ZMAT5 and MS4A7‐C2CD3 were found in 2 of the tumor samples tested. However, these translocations were found only in the single tumor.ConclusionsWe hope that this integrative methodology will elucidate key aspects of tumor biology as well as generate novel targets for cancer diagnoses and therapies. Head Neck, 2012
Repetition related changes in activation and functional connectivity in hippocampus predict subsequent memory
Authors: Manelis Anna , Paynter Christopher A. , Wheeler Mark E. , Reder Lynne M. 
Published: July 2012

AbstractUsing fMRI, this study examined the relationship between repetition‐related changes in the medial temporal lobe (MTL) activation during encoding and subsequent memory for similarity of repetitions. During scanning, subjects classified pictures of objects as natural or man‐made. Each object‐type was judged twice with presentations of either identical pictures or pictures of different exemplars of the same object. After scanning, a surprise recognition test required subjects to decide whether a probe word corresponded to pictures judged previously. When a subject judged the word as “old,” a second judgment was made concerning the physical similarity of the two pictures. Repetition related changes in MTL activation varied depending on whether or not subjects could correctly state that pictures were different. Moreover, psychophysiological interactions analyses showed that accuracy in recalling whether the two pictures were different was predicted by repetition‐related changes in the functional connectivity of MTL with frontal regions. Specifically, correct recollection was predicted by increased connectivity between the left posterior hippocampus and the right inferior frontal gyrus, and also by decreased connectivity between the left posterior hippocampus and the left precentral gyrus on the second stimulus presentation. The opposite pattern was found for trials that were incorrectly judged on the nature of the repetition. These results suggest that successful encoding is predicted by a combination of increases and decreases in both the MTL activation and functional connectivity, and not merely by increases in activation and connectivity as suggested previously. © 2012 Wiley Periodicals, Inc.
Carryover effect on next‐day sleepiness and psychomotor performance of nighttime administered antihistaminic drugs: a randomized controlled trial
Authors: Katayose Yasuko , Aritake Sayaka , Kitamura Shingo , Enomoto Minori , Hida Akiko , Takahashi Kiyohisa , Mishima Kazuo 
Published: July 2012

BackgroundAntihistamines with strong sedative–hypnotic properties are frequently prescribed for insomnia secondary to allergy, but the potential risks of such administration have not been fully elucidated.Subjects and methodsThis randomized, double‐blind, placebo‐controlled crossover study was conducted to evaluate next‐day sleepiness and psychomotor performance following the administration of antihistamines. Twenty‐two healthy male participants participated in four drug administration sessions with more than a 1‐week interval between the sessions. Either zolpidem 10 mg, or diphenhydramine 50 mg, or ketotifen 1 mg, or a placebo was administered before sleep, and polysomnography was conducted to evaluate sleep. In the morning and afternoon of the day after administration, the participants were evaluated for subjective sleepiness, objective sleepiness, and psychomotor performance.ResultsThe antihistamines with high blood–brain barrier‐crossing efficiency were significantly associated with sleepiness and psychomotor performance decline the next day. Ketotifen showed the strongest carryover effect, followed by diphenhydramine. Compared with the placebo, no significant carryover effect was observed with zolpidem.ConclusionThe results suggest that the risk–benefit balance should be considered in the ready use of antihistamines that easily cross the blood–brain barrier for alleviating secondary insomnia associated with allergies. Copyright © 2012 John Wiley & Sons, Ltd.
Detailed characterization of hyaluronan using aqueous size exclusion chromatography with triple detection and multiangle light scattering detection
Authors: Harmon Patricia S. , Maziarz E. Peter , Liu X. Michael 
Published: July 2012

AbstractHyaluronan (HA) has attracted great interest and attention from ophthalmic surgical and eye care companies owing to its unique properties. A more complete understanding of HA biopolymers has, therefore, become increasingly critical as thorough characterization of raw materials helps promote product quality and process control. Often, such detailed information requires the use of a combination of analytical techniques. In this study, we compared size exclusion chromatography (SEC) with online multiangle light scattering (SEC‐MALS) and SEC with triple detection (SEC‐TD) experiments for HA analysis. Three lots of commercially available eye drop grade HA were characterized by SEC‐MALS and SEC‐TD. The absolute molecular weight averages, molecular weight distribution, radius of gyration, and solution conformation of the three HA lots were determined and compared by the two techniques. In addition, the intrinsic viscosity and intrinsic viscosity distribution were measured by SEC‐TD. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.
Pediatric therapeutic plasma exchange indications and patterns of use in us children's hospitals
Authors: Weiss Pamela F. , Klink Andrew J. , Friedman David F. , Feudtner Chris 
Published: July 2012

AbstractPurpose:Therapeutic plasma exchange (TPE) has been increasingly used over the past decade as a first‐line and lifesaving treatment for various conditions classified by the American society for apheresis (ASFA). To date, the degree to which utilization of TPE in pediatrics mirrors recommendations is unknown. Methods: Using inpatient administrative data from 42 children's hospitals we conducted an 8‐year retrospective cohort study of children (≤18 years) with an international classification of diseases‐9‐clinical modification (ICD‐9‐CM) discharge diagnosis indicating an ASFA Category I or II condition, or a procedure code indicating receipt of TPE during hospitalization. Results: TPE was performed during 4,190 hospitalizations of 3,449 patients, of whom 310 (9.0%) and 77 (2.2%) had a primary discharge diagnosis of an ASFA Category I or II condition, respectively. Rates of TPE use for Category I conditions were highest for children with thrombotic thrombocytopenic purpura (TTP), Goodpasture's syndrome, and myasthenia gravis. TPE use in children's hospitals significantly increased from 2003 to 2010, but TPE was performed during only 13.4 and 9.3% of hospitalizations for ASFA Category I and II conditions, respectively. There was significant between‐hospital variation in the use of TPE for Category I conditions as a group and individual Category I conditions including TTP. Conclusion: We found low levels of TPE use across hospitals for key indications, including TTP, a condition for which TPE is considered a first‐line and life‐saving procedure. The variation identified may contribute to varying clinical outcomes between hospitals, warrants further investigation, and represents an important opportunity to improve quality of care. J. Clin. Apheresis 2012. © 2012 Wiley Periodicals, Inc.
Serum Neutrophil Gelatinase‐Associated Lipocalin and Interleukin‐18 as Predictive Biomarkers for Delayed Graft Function After Kidney Transplantation
Authors: Lee Eun Young , Kim Myoung Soo , Park Yongjung , Kim Hyon‐Suk 
Published: July 2012

BackgroundEarly biomarkers for acute kidney injury after kidney transplantation have been studied because delayed graft function (DGF) is associated with increased risk of acute rejection and graft loss. We investigated the usefulness of serum neutrophil gelatinase‐associated lipocalin (NGAL) and interleukin‐18 (IL‐18) for the prediction of DGF after kidney transplantation.Materials and MethodsFifty‐nine kidney transplant recipients were included and they were separated into DGF and immediate graft function (IGF) groups. Serum samples were collected on the preoperative day as well as days 1, 5, and 14 after the transplantation, and assayed for NGAL and IL‐18.ResultsAfter transplantation, serum levels of NGAL were significantly higher at any time in patients with DGF compared to those with IGF. Serum concentrations of IL‐18 were not different between both groups. The receiver operating characteristics(ROC)‐area under the curve (AUC) values of NGAL, IL‐18, and creatinine on day 1 for the discrimination of DGF from IGF were 0.86, 0.63, and 0.65. On POD1, the sensitivities of NGAL and creatinine were respectively 78.6%, and 50.0% at 77.8% specificity, and the AUC values for any combinations including NGAL and that for NGAL alone were higher than that of creatinine.ConclusionSerum NGAL is an early and sensitive marker of graft dysfunction in kidney transplantation, while serum IL‐18 showed limited values. J. Clin. Lab. Anal. 26:286‐294, 2012. © 2012 Wiley Periodicals, Inc.
Transcriptional regulators of the ΔNp63: Their role in limbal epithelial cell proliferation
Authors: Hsueh Yi‐Jen , Kuo Pei‐Ching , Chen Jan‐Kan 
Published: July 2012

AbstractThe surface cells of corneal epithelium are regularly shed off and replaced by new cells that are derived from limbal epithelial stem cells (LESC). LESC are believed to reside in the basal layer of the limbal epithelium and are characterized with high expression levels of ΔNp63, a transcription factor (TF) which is believed to play roles in the regulation of LESC proliferation. In this study, we examined the transcriptional regulation of ΔNp63 in limbal epithelial cell. We employed DNA pull down assay followed by LC/MS analysis and cDNA microarray analysis to identify the TFs that were capable of binding to ΔNp63 promoter or were expressed at higher levels in limbus over cornea. The TFs thus selected were further examined for their in vivo ΔNp63 promoter binding by chromatin immunoprecipitation assay. We identified six putative TFs (PAX6, EGR1, CEBPB, JUN, ATF3, and ARID5B) through the aforementioned approaches. Among them, PAX6 and EGR1 were shown to promote the transcription of ΔNp63 and led to increased cell proliferation. In contrast, CEBPB and ATF3 appeared to exert little or no effect on ΔNp63 expression, however, their silencing suppressed cell proliferation. Although JUN exhibited low promoter‐binding specificity, however, it affected ΔNp63 expression and limbal epithelial cell proliferation in ways similar to that of PAX6 and EGR1. Intriguingly, ARID5B was highly expressed in the limbal epithelial cell, however, its silencing by siRNA did not obviously affect the expression of ΔNp63, nor did it reduce cell proliferation of the limbal epithelial cell. J. Cell. Physiol. 228: 536–546, 2013. © 2012 Wiley Periodicals, Inc.