bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analytical and experimental studies on midstory isolated buildings with modal coupling effect
Authors: Wang Shiang‐Jung , Hwang Jenn‐Shin , Chang Kuo‐Chun , Lin Meng‐Hui , Lee Bo‐Han 
Published: May 2012

SUMMARYIn a midstory isolated building, the isolation system is incorporated into the midstory rather than the base of the building. Because of the flexibility of the substructure below the isolation system in a midstory isolated building, the contribution of higher modes to the seismic responses of the midstory isolated structure may not be negligible, especially when the coupling of higher modes exists. To investigate this modal coupling effect, a simplified three‐lumped‐mass structural model of the midstory isolated building is assumed in this study. Through the equivalent linear analysis and shaking table tests, it is found that the coupling of higher modes may lead to enlarged acceleration responses at the super‐floor and superstructure above the isolation layer. Accordingly, a simple method to prevent the midstory isolation design from the coupling of higher modes attributed to the improper design of the substructure and superstructure is proposed in this paper. Copyright © 2012 John Wiley & Sons, Ltd.
Environmental change, hydromorphological reference conditions and the restoration of Polish Carpathian rivers
Authors: Wyżga Bartłomiej , Zawiejska Joanna , Radecki‐Pawlik Artur , Hajdukiewicz Hanna 
Published: May 2012

ABSTRACTIn the twentieth century Polish Carpathian rivers were considerably modified by channelization and gravel mining, with significant detrimental effects to their ecological integrity, vertical stability of the streambeds and flood hazard to downstream river reaches. Restoration of the rivers is thus necessary to improve their ecological status and re‐establish geomorphic dynamic equilibrium conditions. Various approaches to defining hydromorphological reference conditions, proposed to date in river restoration literature, have serious deficiencies. In particular, environmental changes that took place in the catchments of Carpathian rivers during the twentieth century invalidate the historical state of the rivers as reference for their restoration. This is illustrated by a change from bar‐braided to island‐braided channel pattern that occurred in the past century in unmanaged sections of the Czarny Dunajec in response to a reduction in flow and sediment dynamics of the river. We indicate that reference conditions should be defined as those which exist or would exist under present environmental conditions in the catchment but without human influence on the channel, riparian zone and floodplain of the river which is to be restored. This assumption was tested through the evaluation of hydromorphological river quality of the Czarny Dunajec according to the European Standard EN‐14614. The evaluation confirmed a high‐status hydromorphological quality in an unmanaged channel section, which can thus be used as a reference for restoration of impacted river sections. Copyright © 2012 John Wiley & Sons, Ltd.
Partial response DFT‐precoded‐OFDM modulation
Authors: Kuchi Kiran 
Published: May 2012

ABSTRACTA low peak‐to‐average‐power‐ratio (PAPR) modulation technique is proposed for discrete Fourier transform precoded orthogonal frequency division multiple access (DFT‐precoded‐OFDMA) systems. This technique reduces the PAPR by introducing a phase rotation between successive modulation symbols along with partial response (PR) precoding before feeding the data to a DFT‐precoded‐OFDMA modulator. The PAPR reduction is shown to be quite significant for amplitude‐shift‐keying systems based on real constellations employing π ∕ 2 phase rotation. In particular, for the special case of binary modulation, the combination of phase rotation and PR precoding produces a signal with low amplitude variations. We show that the class of PR precoders obtained by sampling the linearised Gaussian‐minimum‐shift‐keying pulse provides low PAPR and a small degradation in bit‐error‐rate (BER) performance. In particular, the widely linear minimum‐mean‐square‐error (WL‐MMSE) estimation and WL MMSE decision feedback equaliser (WL MMSE‐DFE) methods that jointly filter the signal and its complex conjugate are shown to be useful in mitigating the additional intersymbol interference introduced by the PR precoder. The BER performance is comparable with that of conventional DFT‐precoded‐OFDMA systems employing conventional equalisers.The proposed technique is also suitable for reducing the PAPR of Q‐ary phase‐shift‐keying systems based on complex constellations employing a phase rotation of π ∕ Q. Introduction of Type A‐2 PR precoder that is obtained from the linearised Gaussian‐minimum‐shift‐keying pulse reduces the PAPR by 3.0 dB for quadrature phase‐shift keying, and 2.5 dB reduction is observed for Q‐ary phase‐shift keying with Q ≥8. The intersymbol interference created by the PR precoder causes bit‐error‐rate degradation in the range of 2.0–2.5 dB when conventional MMSE‐DFE receiver is used for symbol detection. Copyright © 2012 John Wiley & Sons, Ltd.
Microwave‐assisted synthesis of disulfides using tetrathiomolybdate: A step toward greener synthesis
Authors: Sidiq Naheed , Bhat Mohsin Ahmad , Khan Khaliquz Zaman , Khuroo Mohammad Akbar 
Published: May 2012

AbstractAn eco‐friendly, efficient, and rapid synthetic procedure for disulfides using benzyl triethyl ammonium tetrathiomolybdate through microwave irradiation of solid support adsorbed reactants is reported. © 2012 Wiley Periodicals, Inc. Heteroatom Chem 23:373–376, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.21025
Combination of bioactive moieties with different heteroatom(s): Application of the Suzuki cross‐coupling reaction
Authors: Patel Rahul V. , Patel Jigar K. , Kumari Premlata , Chikhalia Kishor H. 
Published: May 2012

AbstractTwo series of thiophene/benzothiophene‐linked quinolinyl oxadiazoles condensed to the substituted N‐benzothiazolyl acetamides have been synthesized via the Suzuki cross‐coupling reaction. The ester derivative of 6‐bromo‐substituted quinoline was reacted via the Suzuki cross‐coupling reaction with commercially available (benzo)thiophen‐2‐ylboronic acid at optimized temperature in 1,2‐dimethoxy ethane and water in the presence of potassium carbonate and palladium tetrakis. The resulting derivatives were then hydrazinolized using 99% hydrazine hydrate followed by cyclization using carbon disulfide in ethanolic KOH to furnish the corresponding oxadiazoles, which were then condensed with various substituted 2‐chloro‐N‐benzothiazolyl acetamides to produce the final scaffolds involving a unique combination of four heterocycles to be examined for their antimicrobial activity against two Gram‐positive bacteria (Staphylococcus aureus and Bacillus cereus), three Gram‐negative bacteria (Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae), and two fungal species (Aspergillus niger and Candida albicans). The investigation of biological screening data revealed that the majority of the compounds tested have demonstrated excellent activity (minimum inhibitory concentrations; 6.25–50 µg/mL) against most of the microorganisms as compared with the standard and hence they warrant more consideration as prospective antimicrobial agents. New products (9a–10i) were characterized by physicochemical, elemental, and spectral (IR, 1H NMR, and 13C NMR) data. © 2012 Wiley Periodicals, Inc. Heteroatom Chem 23:399–410, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.21027
Mediating Effect between Supportive Culture and Job Satisfaction in Administrative Services at Higher Education Institutions
Authors: Liou Dian‐Yan , Tu Chia‐Ching , Chang Shu‐Hsuan 
Published: May 2012

AbstractThe purpose of this article is to examine halo effect and organizational commitment in relation to employees' job satisfaction and organizational supportive culture at universities in Taiwan. The study used a questionnaire to collect data from 210 female faculty members of Taiwanese universities. The conceptual model was tested mediating the effect of structural equation modeling with maximum likelihood estimation. This study not only found the mediating role of halo effect and organizational commitment between supportive culture and job satisfaction, but also proved that a supportive culture in universities is directly and positively related to job satisfaction and that emotional and identification‐oriented organizational commitment may affect job satisfaction in a positive way among female faculty members. © 2012 Wiley Periodicals, Inc.
Service systems and the social enterprise
Authors: Tracy Stephen , Lyons Kelly 
Published: May 2012

AbstractService science is an emerging multidisciplinary field concerned with the study of service systems and value cocreation. In recent years, the field has expanded considerably, growing to encompass a community of researchers and practitioners from a range of backgrounds and knowledge domains. However, very little research has focused on the study of service systems within the context of social‐purpose organizations (SPOs), such as a nonprofit charitable organization or an academic institution. We contend that SPOs represent a class of service systems that are understudied in service science. The goal of this study is to contribute to the ongoing development of the discipline's theoretical foundations through an empirical study of a special type of SPO, the social enterprise. Through case‐study research, we analyzed five social enterprise organizations. Our findings point to a number of areas that suggest a bias in service science concepts toward economically motivated and profit‐driven service systems. © 2012 Wiley Periodicals, Inc.
EXCHANGE RATE REVERSION UNDER REGIMES OTHER THAN FREE FLOAT
Authors: Lin Luke , Lin Wenyuan 
Published: May 2012

ABSTRACTSeveral studies indirectly point out that the exchange rate system may be one of the factors for establishing purchasing power parity (PPP). However, current researches on PPP have mainly focused on the recent floating period and need various statistical models to carry out. We use quantile autoregression technique to comprehensively examine the mean reversion properties of the New Taiwan Dollar (NTD), where the NTD was both in a fixed regime period and a managed floating system period. Empirical findings indicate that NTD showed comparatively faster recovery when subjected to a larger or positive disturbance from the market. Additionally, when NTD was in a fixed regime period, PPP was mostly established. But during the managed floating system period, it was only partially established. These results suggest that mean reversion of real exchange rate heavily depends on the regime effect. Copyright © 2012 John Wiley & Sons, Ltd.
NSAIDs induce apoptosis in nonproliferating ovarian cancer cells and inhibit tumor growth in vivo
Authors: Duncan Kristal , Uwimpuhwe Henriette , Czibere Akos , Sarkar Devanand , Libermann Towia A. , Fisher Paul B. , Zerbini Luiz F. 
Published: May 2012

AbstractOvarian cancer (OC) is one of the most lethal gynaecological cancers, which usually has a poor prognosis due to late diagnosis. A large percentage of the OC cell population is in a nonproliferating and quiescent stage, which poses a barrier to success when using most chemotherapeutic agents. Recent studies have shown that several nonsteroidal anti‐inflammatory drugs (NSAIDs) are effective in the treatment of OC. Furthermore, we have previously described the molecular mechanisms of NSAIDs' induction of cancer apoptosis. In this report, we evaluated various structurally distinct NSAIDs for their efficacies in inducing apoptosis in nonproliferating OC cells. Although several NSAIDs‐induced apoptosis, Flufenamic Acid, Flurbiprofen, Finasteride, Celocoxib, and Ibuprofen were the most potent NSAIDs inducing apoptosis. A combination of these agents resulted in an enhanced effect. Furthermore, we demonstrate that the combination of Flurbiprofen, which targets nonproliferative cells, and Sulindac Sulfide, that affects proliferative cells, strongly reduced tumor growth when compared with a single agent treatment. Our data strongly support the hypothesis that drug treatment regimens that target nonproliferating and proliferating cells may have significant efficacy against OC. These results also provide a rationale for employing compounds or even chemically modified NSAIDs, which selectively and efficiently induce apoptosis in cells during different stages of the cell cycle, to design more potent anticancer drugs. © 2012 IUBMB IUBMB Life, 64(7): 636–643, 2012
Moderate intensity static magnetic field has bactericidal effect on E. coli and S. epidermidis on sintered hydroxyapatite
Authors: Bajpai Indu , Saha Naresh , Basu Bikramjit 
Published: May 2012

AbstractThe application of electromagnetic field in the context of bacteria associated infections on biomaterial surfaces has not been extensively explored. In this work, we applied a moderate intensity static magnetic field (100 mT) to understand the adhesion and growth behavior of both gram positive (S. epidermidis) and gram negative bacteria (E.
coli) and also to investigate bactericidal/bacteriostatic property of the applied electromagnetic field. An in‐house built magnetometer was used to apply static homogeneous magnetic field during a planned set of in vitro experiments. Both the sintered hydroxyapatite (HA) and the control samples seeded with bacteria were exposed to the magnetic field (100 mT) for different timescale during their log phase growth. Quantitative analysis of the SEM images confirms the effect of electromagnetic field on suppressing bacterial growth. Furthermore, cell integrity and inner membrane permeabilization assays were performed to understand the origin of such effect. The results of these assays were statistically analyzed to reveal the bactericidal effect of magnetic field, indicating cell membrane damage. Under the investigated culture conditions, the bactericidal effect was found to be less effective for S. Epidermidis than E.
coli. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 2012:100B:1206–1217, 2012.
Experimental repair of segmental bone defects in rabbits by angiopoietin‐1 gene transfected MSCs seeded on porous β‐TCP scaffolds
Authors: Cao Le , Liu Xudong , Liu Shen , Jiang Yao , Zhang Xianlong , Zhang Changqing , Zeng Bingfang 
Published: May 2012

AbstractSegmental bone defect repair remains a clinical and experimental challenge in tissue engineering with increasing focus on angiogenesis in the bone substitutes. The objective of this study was to investigate the osteogenic effects of angiopoietin‐1 (Ang‐1) gene transfected bone marrow‐derived mesenchymal stem cells (MSCs) seeded on porous β‐TCP scaffolds. This bone substitute (experimental group) and MSCs/β‐TCP compounds (control group) were implanted into 15 mm segmental bone defects of the radii of 30 New Zealand white rabbits, with platelet‐rich plasma injected at the same time. Bone regeneration and angiogenesis were assessed by Scanning electron microscope (SEM), X‐ray, histology, immunohistology, and biomechanical outcome measurements made on the 2nd, 4th, 8th, and 12th week after the operation. In vitro, the amount of proliferation and differentiation of Ang‐1 gene transfected MSCs was found to be gross increased than that of the control groups. In vivo, a significantly increased amount of new bone formation accompanied by active capillary vasculature regeneration was observed in the pores of the scaffolds which had been seeded with Ang‐1 gene transfected MSCs, as compared with the control groups. The biomechanical test confirmed the failure load of new born bone was close to normal bone. These results suggest that transfer of gene encoding Ang‐1 to MSCs increases their osteogenic properties by enhancing capillary regeneration, thus providing a rich blood supply for new bone formation in segmental bone defects. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.
Physicochemical properties and in vitro biocompatibility of a hydraulic calcium silicate/tricalcium aluminate cement for endodontic use
Authors: Liu Weining , Peng Weiwei , Zhu Yaqin , Chang Jiang 
Published: May 2012

AbstractThis study sought to prepare a calcium silicate cement (CSC) with varying additions of tricalcium aluminate (Ca3Al2O6, C3A), and to find an optimal amount of C3A by evaluating the effect of C3A on the physicochemical and in vitro biological properties of the CS/C3A cement. The results indicated that the addition of C3A into CSC reduced the setting time and improved the compressive strength especially at the early stage of setting. However, the 15% C3A was too much for the CS/C3A system and did harm to its strength development. Furthermore, the CS/C3A cement was bioactive and biocompatible in vitro, and had a stimulatory effect on the cell growth, when the content of C3A was 5 or 10%. When compared with the commercially available Dycal®, the CS/C3A cement was notably more compatible with the human dental pulp cells. Therefore, the CS/C3A cement with 5–10% C3A produced the best compromise between setting and in vitro biological properties, and may be a promising candidate for endodontic use. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.
A generalized reference state extends the applicability of approximative kinetics in metabolic engineering
Authors: Nikerel Emrah , Verheijen Peter J. T. , Heijnen Joseph J. 
Published: May 2012

AbstractBACKGROUND: The use of approximative kinetics for modeling enzyme kinetics and for metabolic engineering purposes has become increasingly attractive. Despite a list of advantages, the proposed use of a steady state for reference limits the use of such kinetic formats.RESULTS: Here, to avoid these limitations, an alternative formulation is proposed for the linlog approximative kinetics introducing ‘a characteristic set’ for normalization. The necessary equations for the parameter (elasticities and the reaction rate of the characteristic set) estimation framework using data obtained from various types of perturbation experiments are given. The use of the new formulation is exemplified with three illustrative examples: parameter estimation in steady state and in dynamic experiments; and prediction of the effect of a mutation in enzyme kinetics properties. The implications of the new formulation are discussed.CONCLUSIONS: By introducing a so‐called characteristic set, we show that the approximative quality of this kinetics is improved and this formulation can be used to analyze and model data from a broader set of experimental scenarios. Copyright © 2012 Society of Chemical Industry
Promiscuous enzyme‐catalyzed Michael addition: synthesis of warfarin and derivatives
Authors: Xie Bang‐Hua , Guan Zhi , He Yan‐Hong 
Published: May 2012

AbstractBACKGROUND: Biocatalytic promiscuity has attracted much attention from chemists and biochemists in recent years. Warfarin, one of the most effective anticoagulants, has been introduced for clinical use as a racemate for more than half a century. Although some different chemical strategies towards the synthesis of optically active warfarin have been reported, biocatalytic preparation of warfarin remains unexploited.RESULTS: Lipase from porcine pancreas (PPL) was used as a biocatalyst to catalyze the Michael addition of 4‐hydroxycoumarin to α,β‐unsaturated enones in organic medium in the presence of water to synthesize warfarin and derivatives. The products were obtained in moderate to high yields (up to 95%) with none or low enantioselectivities (up to 28% ee). The influence of reaction conditions including solvents, temperature and molar ratio of substrates was systematically investigated.CONCLUSION: Among the many reported lipase‐catalyzed Michael additions, only a few showed enantioselectivity. Therefore, this Michael addition activity of, for example, PPL is a valuable case of enantioselective lipase catalytic promiscuity. In addition, it was the first time warfarin and derivatives were prepared using a biocatalyst. Copyright © 2012 Society of Chemical Industry
Subject movement during multislice interleaved MR acquisitions: Prevalence and potential effect on MRI‐derived brain pathology measurements and multicenter clinical trials of therapeutics for multiple sclerosis
Authors: Gedamu Elias L. , Gedamu Abraham 
Published: May 2012

AbstractPurpose:To show the prevalence of inter‐packet motion in clinical trial magnetic resonance imaging (MRI) data and the effect of inter‐packet motion on MRI‐derived brain pathology measurements.Materials and Methods:We present a method to detect and quantify inter‐packet motion, apply it to 2384 MRIs to determine the prevalence of inter‐packet motion in clinical trial data, and show the effect of inter‐packet motion on measuring multiple sclerosis (MS) lesion volumes.Results:Experiments with simulated data showed that the detection procedure was accurate at measuring the amount of movement between packets and quantifying the amount of missing data. Application to clinical trial data demonstrated that a large number of MRIs had missing data due to inter‐packet motion; 20% of the images had greater than 10% of the data missing and 10% of the images had greater than 15% of the data missing. These levels corresponded to thresholds where lesions were difficult to visually identify or disappeared completely. Lesion volume measurement errors ranged from 1.3 ± 0.5% to 9.9 ± 6.3%.Conclusion:Inter‐packet motion can introduce substantial errors to MRI‐derived brain pathology measurements. The prevalence of inter‐packet motion is substantial in MS clinical trial data. Automated detection procedures should be implemented to increase the fidelity of MRI‐derived measurements. J. Magn. Reson. Imaging 2012;36:332–343. © 2012 Wiley Periodicals, Inc.
The twisted tale of saturated fat
Authors: Volek Jeff S. , Volk Brittanie M. , Phinney Stephen D. 
Published: May 2012

AbstractRecent research results mandate a careful re‐evaluation of the widespread belief that dietary saturated fat is harmful. Specifically, multiple recent reports find no association between dietary saturated fat intakes and cardiovascular disease (CVD). There is, however, a consistent pattern of increased risk for both CVD and type‐2 diabetes associated with increased levels of saturated fatty acids (SFA) in circulating lipids. This raises the important question as to what contributes to increased levels of saturated fat in the blood? Whereas dietary intake of saturated fats and serum levels of SFA show virtually no correlation, an increased intake of carbohydrate is associated with higher levels of circulating SFA. This leads to the paradoxical conclusion that dietary saturated fat is not the problem; rather it's the over‐consumption of carbohydrate relative to the individual's ability to metabolize glucose without resorting to de novo lipogenesis. From this perspective, insulin resistant states like metabolic syndrome and type‐2 diabetes can be viewed as carbohydrate intolerance, in which a high carbohydrate intake translates to increased serum SFA and therefore increased risk.