bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the causal association between systemic lupus erythematosus and migraine using Mendelian randomization analysis
Authors: Xu Danfeng , Wu Bing 
Published: April 2024

AbstractObjectiveTo assess whether systemic lupus erythematosus (SLE) may be genetically causally associated with migraine, including the two primary subtypes: migraine with aura (MWA) and migraine without aura (MWoA).BackgroundThe association between SLE and migraine has been investigated extensively. Previous studies have shown a higher prevalence of migraine in patients with SLE, although the exact relationship remains unclear. This study investigated the potential causal association between SLE and migraine using the powerful analytical tool of Mendelian randomization (MR).MethodsWe performed two‐sample MR analysis of publicly available summary statistic datasets using inverse variance‐weighted (IVW), weighted median, and MR‐Egger methods based on an SLE genome‐wide association study (GWAS; 5201 cases; 9066 controls; the exposure frequency is 36.5%) as an exposure and migraine GWAS (15,905 cases; 264,662 controls) in individuals with European ancestry as outcomes, focusing on the two migraine subtypes MWA (6780 cases; 264,662 controls) and MWoA (5787 cases; 264,662 controls). Thepleiotropy and heterogeneity were performed.ResultsWe selected 42 single‐nucleotide polymorphisms from SLE GWAS as instrumental variables (IVs) for SLE on migraine, and 41 SNP IVs for SLE on MWA or MWoA. The IVW (odds ratio [OR] = 1.01, 95% confidence interval [CI] = [0.99, 1.03], p = 0.271), weighted median (OR = 1.00, 95% CI = [0.97, 1.03], p = 0.914), and MR‐Egger (OR = 1.04, 95% CI = [0.99, 1.09], p = 0.153) methods showed no causal effect of SLE on migraine. A causal effect of SLE was observed on MWA (IVW: OR = 1.05, 95% CI = [1.02, 1.08], p = 0.001; weighted median: OR = 1.05, 95% CI = [1.01, 1.10], p = 0.018; MR‐Egger: OR = 1.07, 95% CI = [1.01, 1.14], p = 0.035 and pIVW < 0.017 [Bonferroni correction]) but not MWoA (IVW: OR = 0.99, 95% CI = [0.96, 1.02], p = 0.331; weighted median: OR = 0.98, 95% CI = [0.94, 1.03], p = 0.496; MR‐Egger: OR = 1.02, 95% CI = [0.95, 1.09], p = 0.652). The results showed no significant pleiotropy or heterogeneity.ConclusionOur MR analysis demonstrated the complex relationship between SLE and migraine, suggesting a potential effect of SLE on the risk of MWA but not MWoA. These findings can aid in the development of improved subtype‐specific management of migraine in patients with SLE.
The historical development and current landscape of health library standards: A critical review
Authors: De‐la‐Mano Marta 
Published: April 2024

AbstractBackgroundSince the emergence of the first health library standards, a large body of literature has been published in this field, most often focusing on a particular standard, or set of standards. In the case of literature reviews, they have been usually partial and integrated into a broader study.ObjectiveIdentify and analyse national health library standards developed in different countries worldwide over the past 70 years, tracing their historical development and current status.MethodA comprehensive search of published literature was conducted in Scopus, Web of Science, Medline, LISA, and Google Scholar up to May 2023. The reference lists and citations of retrieved papers were reviewed. After screening and eligibility, a total of 112 papers were included in the final selection.ResultsMore than 40 national hospital library standards published by a group of Anglo‐Saxon and European countries were identified. In a chronological approach, the standards have been arranged by decades, from the 1950s to the present day, and the context of their appearance, their main contributions, and the relationships between them have been analysed. The major trends that have marked their evolution and development over time have also been established.ConclusionStandards have a key role to play in the important challenge facing health libraries today to demonstrate the high impact and value of their services in the functioning of their organisations and in improving patient care.
Mistreatment of nurses by patients and its impact on their caring behaviors: The roles of psychological detachment and supervisor positive gossip
Authors: Zoromba Mohamed A. , Abousoliman Ali D. , Zakaria Abeer Mohamed , El‐Monshed Ahmed Hashem , El‐Gazar Heba E. 
Published: April 2024

AbstractBackgroundMistreatment by patients is a detrimental phenomenon predominant in healthcare organizations. However, there is a lack of nursing literature regarding the underlying mechanisms and boundary conditions that exist between mistreatment by patients and its detrimental consequences.AimBy integrating the Job Demands–Resources Model and the Conservation of Resources Theory, the study aimed to unveil the mediating role of psychological detachment from work in the relationship between mistreatment by patients and nurses' caring behaviors, as well as the moderating effect of supervisor positive gossip.MethodsThis multicenter, cross‐sectional study involved 341 nurses from five hospitals across two cities in Egypt. Data were collected using an introductory information form, the Mistreatment by Patients Scale, the Psychological Detachment Scale, the Caring Behaviors Scale, and the Supervisor Positive Gossip Scale. The study's hypotheses were tested using the PROCESS macro.ResultsThe results showed that mistreatment by patients was negatively related to nurses' caring behaviors via an increased psychological detachment. Further, higher levels of supervisor positive gossip were shown to weaken the direct effect of mistreatment by patients in increasing nurses' psychological detachment, as well as the indirect negative effect of mistreatment by patients on nurses' caring behaviors via psychological detachment.ConclusionsMistreatment by patients contributes to nurses' psychological detachment and decreased caring behaviors; however, these negative outcomes can be mitigated by supervisor positive gossip.Implication for nursing policymakingNursing managers should adopt strategies to deter the rise of mistreatment by patients, and utilize positive gossip to support nurses exposed to such mistreatment to alleviate its consequences.
Impact of clinical pathway implementation satisfaction, work engagement, and hospital–patient relationship on quality of care in Chinese nurses
Authors: Li Junlong , Xiang Lijia , Li Qin , Liu Jie , Pan Jay 
Published: April 2024

AbstractAimsThis study aimed to investigate how clinical pathway implementation satisfaction, work engagement, and hospital–patient relationship impact the quality of care that is provided by nurses in public hospitals.BackgroundClinical pathways are recommended as a form of quality improvement by broader healthcare systems and are widely used in the world. Nurses are the most involved group of healthcare professionals in the implementation of clinical pathways in public hospitals. So, it is important to investigate how their satisfaction with the process affects the quality of care they provide and influencing factors.MethodsThis descriptive cross‐sectional study surveyed nurses practicing across seven tertiary public hospitals in Sichuan Province, China, online. The survey consisted of a questionnaire for the general characteristics of the participants and four Chinese maturity scales validated by previous studies: clinical pathway implementation satisfaction scale, work engagement scale, hospital–patient relationship perception scale, and quality of care scale. The bootstrap method was used to test a moderated mediation model using Hayes' PROCESS macro models 4 and 8. We followed STROBE guidelines to prepare the study report.ResultsA total of 880 nurses filled out the questionnaires, 821 of which were regarded as valid. Clinical pathway implementation satisfaction had a positive effect on quality of care (B = 0.873, P < 0.001). Work engagement played a mediation role between nurses' clinical pathway implementation satisfaction and the quality of care (effect = 0.080, Boot 95% CI = [0.023, 0.142]). This mediation model was moderated by the hospital–patient relationship (P < 0.01).ConclusionClinical pathway implementation satisfaction may enhance the quality of care by work engagement of nurses. Moreover, a good hospital–patient relationship can enhance the positive impact of nurses' satisfaction on work engagement and health service quality.Implications for nursing and nursing policyPublic hospital managers need to pay attention to nurses' evaluation of and perceptions toward clinical pathway implementation and then take corresponding measures to improve their satisfaction to enhance the quality of care. At the same time, the government, society, and hospitals also need to foster good hospital–patient relationships to ensure that nurses have a high level of work engagement that aids in providing high‐quality care services.
Basic income as a pandemic social protection instrument: Lessons from Maricá, Brazil
Authors: De Wispelaere Jurgen , Morales Leticia , Waltenberg Fabio 
Published: April 2024

AbstractThis article explores the connection between two related but distinct models of basic income proposals in the context of a pandemic emergency. While COVID‐19 appears to have increased interest in basic income, this often ended up taking the form of a temporary emergency basic income (EBI) instead of a permanent universal basic income (UBI). In this article we argue that the “dial up/dial down” model of basic income allows us to link EBI and UBI in a way that offers both a practical response to important implementation challenges in emergency policy making and a strategic argument in favour of UBI as a pandemic policy instrument. We illustrate our argument by contrasting the Renda Básica de Cidadania (RBC) in the municipality of Maricá, Brazil, with two comparable programmes in the same region.
What role for emergency basic income in building and strengthening rights‐based universal social protection systems?
Authors: Orton Ian , Markov Kroum , Plaza‐Stern Maya 
Published: April 2024

AbstractDuring the COVID‐19 pandemic there were a great many social protection policy responses. There were also calls for emergency basic income (EBI) to be adopted as a mitigation response. However, it seems that only one country adopted an EBI. Nonetheless, EBI is likely to feature in future policy discussion and action, especially as a crisis‐mitigation tool. This has implications for the future of rights‐based social protection. Consequently, this article aims to examine whether EBI would comply with international social security standards and whether it could contribute to building and strengthening rights‐based universal social protection systems.
Drugs associated with epidermal necrolysis in children: A World Health Organization pharmacovigilance database analysis
Authors: Bataille Pauline , Lebrun‐Vignes Benedicte , Bettuzzi Thomas , Ingen‐Housz‐Oro Saskia , Hadj‐Rabia Smail , Welfringer‐Morin Anne , Bodemer Christine 
Published: April 2024

AbstractBackgroundStevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare life‐threatening mucocutaneous reactions most often induced by drugs. To date, no large pharmacovigilance study has been conducted in the paediatric population.ObjectivesTo describe the spectrum of drugs associated with SJS‐TEN in children through the analysis of cases reported in the WHO pharmacovigilance database (VigiBase).MethodsDisproportionality study using data from VigiBase. All paediatric (age under 18 years) cases reported between January 1, 1967, and July 6, 2022, were included. For each molecule, a case–non‐case study was performed to assess a potential pharmacovigilance signal by computing the lower end of the 95% credibility interval for the information component (IC025). We performed sensitivity analyses, (i) taking into account only cases reported by physicians and (ii) taking into account only cases reported in the last 10 years.ResultsAmong 31,376,783 adverse drug reactions reported in VigiBase, 2,248,727 were paediatric cases and 7342 were encoded as paediatric SJS‐TEN. Significant statistical pharmacovigilance signals were observed for 165 drugs. The two most represented drug classes were antiepileptics and anti‐infectious drugs. The five drugs with the highest IC025 were lamotrigine (IC025 4.99), carbamazepine (IC025 4.88), phenobarbital (IC025 4.67), phenytoin (IC025 4.52) and nimesulide (IC025 4.23). Acetaminophen was significantly associated with paediatric SJS‐TEN (IC025 2.85) and we also described various new suspected drugs. Vaccines had no significant pharmacovigilance signal. These results were confirmed with the sensitivity analyses.ConclusionsThis study updates the spectrum of drugs potentially associated with paediatric SJS‐TEN.
Monitoring strategies during the establishment phase of Aethina tumida on Oahu, Hawaii
Authors: Villalobos E. M. , Nikaido S. , Ito T. , Wong J. 
Published: April 2024

AbstractThe small hive beetle Aethina tumida (SHB) Murray,1867, is an invasive bee pest that is expanding its range across Latin America, parts of Australia and the Philippines, and is now established in two regions in Italy. However, despite multiple recent introductions, there is scant information about the dynamics of the initial stages of colonization of the SHB and this knowledge gap could impact management and quarantine strategies decisions for many countries. This note describes the monitoring strategies and the patterns of SHB establishment in a previously SHB‐free apiary on the island of Oahu, Hawaii in 2010–2011. The weekly hive inspections, conducted over a ten‐month period, showed that beetle prevalence increased slowly at the apiary level, and adult beetles were more commonly found (87.9%) inside the oil traps that were placed inside the hives between the outermost frames of the hive. There were relatively few “free roaming” beetles detected at this point and they were more often found on the side frames and underneath the cover of the hive, not on the floor of the hive. The results also suggest that in the early stages of colonization careful visual inspections of the frames of each colony had relatively low detection success when compared to oil traps. Our results support previous modelling studies that suggest the need to inspect a high proportion of colonies per apiary (>80%) to ensure a 5% detection rate during the initial stages of invasion.
Derailment in adolescence: Factor analytic structure and correlates
Authors: Ratner Kaylin , Zhu Gaoxia , Li Qingyi , Rice Marissa , Estevez Melody , Burrow Anthony L. 
Published: April 2024

AbstractDerailment is the sense of being “off‐course” in life. But what could this mean for adolescents, who are often establishing identity and self‐direction for the first time? We examined the structure and correlates of the Derailment Scale and its short form, the Derailment Scale‐6 (DS‐6), among middle‐to‐late adolescents (N = 452). Both scales exhibited unidimensionality, but the DS‐6 demonstrated superior fit and correlated with cross‐sectional distress markers (e.g., greater depression, lower life satisfaction, strained sense of purpose). Breaking from adult‐based research, we failed to find evidence that derailment related to adolescent identity exploration and commitment. In extending assessment of derailment to adolescence, this study invites exploration of this experience during a time characterized by substantial transition and the emergence of stable self‐views.
Industrial and academic approaches to the search for alternative melatonin receptor ligands: An historical survey
Authors: Bedini Annalida , Boutin Jean A. , Legros Céline , Zlotos Darius P. , Spadoni Gilberto 
Published: April 2024

AbstractThe search for melatonin receptor agonists formed the main part of melatonin medicinal chemistry programs for the last three decades. In this short review, we summarize the two main aspects of these programs: the development of all the necessary tools to characterize the newly synthesized ligands at the two melatonin receptors MT1 and MT2, and the medicinal chemist's approaches to find chemically diverse ligands at these receptors. Both strategies are described. It turns out that the main source of tools were industrial laboratories, while the medicinal chemistry was mainly carried out in academia. Such complete accounts are interesting, as they delineate the spirits in which the teams were working demonstrating their strength and innovative character. Most of the programs were focused on nonselective agonists and few of them reached the market. In contrast, discovery of MT1‐selective agonists and melatonergic antagonists with proven in vivo activity and MT1 or MT2‐selectivity is still in its infancy, despite the considerable interest that subtype selective compounds may bring in the domain, as the physiological respective roles of the two subtypes of melatonin receptors, is still poorly understood. Poly‐pharmacology applications and multitarget ligands have also been considered.
Diagnostic findings in sinonasal aspergillosis in dogs in the United Kingdom: 475 cases (2011–2021)
Authors: Prior C. , Swales H. , Sharman M. , Reed N. , Bommer N. , Kent A. , Glanemann B. , Clarke K. , Kortum A. , Kelly D. , Lea C. , Roberts E. , Rutherford L. , Tamborini A. , Murphy K. , Batchelor D. J. , Calleja S. , Burrow R. , Jamieson P. , Best M. , Borgonovi S. , Calvo‐saiz I. , Elgueta I. , Piazza C. , Gil Morales C. , Hrovat A. , Keane M. , Kennils J. , Lopez E. , Spence S. , Izaguirre E. , Hernandez‐Perello M. , Lau N. , Paul A. , Ridyard A. , Shales C. , Shelton E. , Farges A. , Specchia G. , Espada L. , Fowlie S. J. , Tappin S. , Van den Steen N. , Sparks T. H. , Allerton F. 
Published: April 2024

ObjectivesTo describe the diagnostic tests used and their comparative performance in dogs diagnosed with sinonasal aspergillosis in the United Kingdom. A secondary objective was to describe the signalment, clinical findings and common clinicopathologic abnormalities in sinonasal aspergillosis.Materials and MethodsA multi‐centre retrospective survey was performed involving 23 referral centres in the United Kingdom to identify dogs diagnosed with sinonasal aspergillosis from January 2011 to December 2021. Dogs were included if fungal plaques were seen during rhinoscopy or if ancillary testing (via histopathology, culture, cytology, serology or PCR) was positive and other differential diagnoses were excluded.ResultsA total of 662 cases were entered into the database across the 23 referral centres. Four hundred and seventy‐five cases met the study inclusion criteria. Of these, 419 dogs had fungal plaques and compatible clinical signs. Fungal plaques were not seen in 56 dogs with turbinate destruction that had compatible clinical signs and a positive ancillary test result. Ancillary diagnostics were performed in 312 of 419 (74%) dogs with observed fungal plaques permitting calculation of sensitivity of cytology as 67%, fungal culture 59%, histopathology 47% and PCR 71%.Clinical SignificanceThe sensitivities of ancillary diagnostics in this study were lower than previously reported challenging the clinical utility of such tests in sinonasal aspergillosis. Treatment and management decisions should be based on a combination of diagnostics including imaging findings, visual inspection, and ancillary testing, rather than ancillary tests alone.
Limited genomic signatures of population collapse in the critically endangered black abalone (Haliotis cracherodii)
Authors: Wooldridge Brock , Orland Chloé , Enbody Erik , Escalona Merly , Mirchandani Cade , Corbett‐Detig Russell , Kapp Joshua D. , Fletcher Nathaniel , Cox‐Ammann Karah , Raimondi Peter , Shapiro Beth 
Published: April 2024

AbstractThe black abalone, Haliotis cracherodii, is a large, long‐lived marine mollusc that inhabits rocky intertidal habitats along the coast of California and Mexico. In 1985, populations were impacted by a bacterial disease known as withering syndrome (WS) that wiped out >90% of individuals, leading to the closure of all U.S. black abalone fisheries since 1993. Current conservation strategies include restoring diminished populations by translocating healthy individuals. However, population collapse on this scale may have dramatically lowered genetic diversity and strengthened geographic differentiation, making translocation‐based recovery contentious. Additionally, the current prevalence of WS remains unknown. To address these uncertainties, we sequenced and analysed the genomes of 133 black abalone individuals from across their present range. We observed no spatial genetic structure among black abalone, with the exception of a single chromosomal inversion that increases in frequency with latitude. Outside the inversion, genetic differentiation between sites is minimal and does not scale with either geographic distance or environmental dissimilarity. Genetic diversity appears uniformly high across the range. Demographic inference does indicate a severe population bottleneck beginning just 15 generations in the past, but this decline is short lived, with present‐day size far exceeding the pre‐bottleneck status quo. Finally, we find the bacterial agent of WS is equally present across the sampled range, but only in 10% of individuals. The lack of population genetic structure, uniform diversity and prevalence of WS bacteria indicates that translocation could be a valid and low‐risk means of population restoration for black abalone species' recovery.
Evaluation ofLong‐termcolour resistance of composite materials used in aligner treatments: A comparative study
Authors: Yildiz Hilal , Dedeoglu Mustafa , Aydemir Merve , Oktay Hüsamettin 
Published: April 2024

AbstractAimThe aim of this study is to evaluate the discolouration resistance of attachments made of composites having different physical properties, filler ratios and viscosity through the simulated environment and conditions.Materials and MethodsSeventy‐two extracted human teeth were aligned to simulate upper and lower dental arches. The attachments were prepared according to the guides determined by ClearCorrect. Three different composite groups were used for attachments preparation: Aligner Connect, G‐Aenial Universal Injectable, and Tetric Prime and Tetric Evoflow combination. Dental models and aligners were kept in artificial saliva throughout the experiment of 96 weeks. The aligners were also subjected to 2308 thermal cycles and insertion and removing procedures 840 times for each period of 12 weeks. Afterwards, the models were kept in coffee and red wine solutions. Colour measurements were made with Vita Easy Shade 4.0 at 12th, 24th, 48th and 96th simulated weeks.ResultsNo significant difference in discolouration was observed during thermal cycle application of 12th and 24th week experimental periods. In the later periods, discolouration was observed in the composite materials, and G‐Aenial Universal Injectable was less coloured than the other samples. The composite samples were more coloured in proportion to their residence time. The G‐Aenial Universal Injectable was more affected by wine solution, and Tetric Prime and Tetric Evoflow combination were more affected by coffee solution.ConclusionsViscosity, resin matrix content and nature of inorganic filler particles of the composite materials significantly affect the colour changing properties of them due to the long‐term ageing and exposure to colouring agents.