bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generation of multiple user-defined dispersive waves in a silicon nitride waveguide
Authors: Yang Yijun , Turpaud Victor , Lafforgue Christian , Melati Daniele , Wilmart Quentin , Faugier-Tovar Jonathan , Gianini Linda , Edmond Samson , Cassan Eric , Marris-Morini Delphine , Alonso-Ramos Carlos , Vivien Laurent 
Published: June 2024

The quest for a wide and bright supercontinuum source has received
significant attention, addressing pivotal challenges in ultra-fast
spectroscopy, imaging, and frequency metrology. Among the diverse
optical nonlinear mechanisms steering supercontinuum generation,
dispersive waves emerge as crucial contributors, providing heightened
spectral intensity, wavelength tunability, and superior temporal
coherence. Nevertheless, their generation is tightly bound by
waveguide geometry, limiting both their numbers and the wavelengths at
which they manifest. In this paper, we demonstrate the controlled
generation of multiple dispersive waves in fundamental optical
transverse mode by leveraging quasi phase-matching in an integrated
silicon nitride (Si3N4) waveguide. This approach involves
modulating the group velocity dispersion through varying the width of
the Si3N4 waveguide crossing anomalous and
normal dispersion, which facilitates the creation of diverse
dispersive waves in fundamental transverse electromagnetic (TE)
polarization at multiple phase-matched wavelengths. A wide nonlinear
optical spectral broadening surpassing conventional approaches is
achieved with good temporal and spatial coherence. Remarkably, the
generation of the multiple dispersive waves and the supercontinuum is
achieved by a 190-fs pulse duration pump with peak power as low as
110 W (24 pJ). This work offers flexibility to
manipulate dispersive waves in an integrated platform beyond current
dispersion engineering. It represents a significant step forward in
developing an integrated broadband source with a user-defined spectral
shape, accomplished with minimal pump power requirements.
Implementation of gender-based violence screening guidelines in public HIV treatment programs: A mixed methods evaluation in Uganda
Authors: Thomas Dorothy , Nalumansi Alisaati , Reichman Mira , Metitiri Mine , Nambi Florence , Kibuuka Joseph , Nakabugo Lylianne , Kamusiime Brenda , Kasiita Vicent , Nalukwago Grace K. , Muwonge Timothy R. , Simoni Jane , Montgomery Elizabeth T. , Mujugira Andrew , Heffron Renee 
Published: June 2024

Background
HIV and gender-based violence (GBV) intersect to threaten population health. The Uganda Ministry of Health recommends routine GBV screening alongside HIV care but evidence detailing its implementation in HIV care settings is limited. We evaluated screening practices in public HIV clinics to generate evidence supporting GBV screening optimization.

Methods
To evaluate GBV screening implementation in antiretroviral therapy (ART) clinics, we extracted client data from GBV registers at 12 public ART clinics in Uganda (January 2019-December 2021). We concurrently evaluated perceptions of GBV screening/referral practices by conducting in-depth qualitative interviews with providers (N = 30) and referral partners (N = 10). We contextualized quantitative findings with interview data which were analyzed using a thematic analysis approach.

Results
During the evaluation period, >90% of providers in participating health facilities implemented GBV screening. Among 107,767 clients served in public ART clinics, providers identified 9,290 (8.6%) clients who experienced past-year physical, sexual and/or emotional GBV of whom 86% received counseling and 19% were referred to support services—most commonly to legal services. Key factors influencing GBV screening implementation included awareness of screening guidelines; client volume; and client’s level of engagement in HIV care. Providers and referral partners identified important benefits to clients (e.g., pursuit of justice and removal from violent environments) when referrals were successful. Key factors influencing referrals included financial constraints that limited referral partners’ ability to provide services at no cost to clients and socio-cultural norms that inhibited client willingness to pursue support services.

Conclusions
GBV screening implementation in ART clinics supports identification and referral of clients exposed to violence. The effectiveness of GBV screening may be limited by socio-cultural factors that inhibit client capacity to pursue referrals and fragmented and resource-constrained referral networks. Providers and referral partners identified allocating funds to support referrals and collaborative networking meetings as important opportunities for strengthening GBV referrals.
Discerning the functional role of plasmalogen at the synapse by shotgun lipidomics
Authors: Gane Iwan , Coates Kathryn , Hunter Ann , Angelini Roberto 
Published: June 2024

We seek to investigate the functional role of PEp in neurons with aims to better understand its involvement in neurodegeneration and the potential of clinical applications targeting its metabolism. To achieve this, we have developed a simple
in vitro neuronal model to assay synapse function while modulating PEp levels. SH-SY5Y neuroblastoma cells are differentiated into neuron-like cells by serum starvation and incubation with neurotropic factors. These cells exhibit a highly polarised, neuron-like morphology, forming neural networks and co-localised pre- and post-synaptic markers. Plasmalogen levels and speciation are modulated by post-transcriptional gene silencing of PEp biosynthetic enzymes and supplementation with plasmalogen precursors and labelled PUFA. PEp levels are analysed by shotgun lipidomics in parallel with assays of synaptic assembly and protein expression including ICC/IF, PCR, and Western Blot.
For targeted ESI-HRAM-MS/MS shotgun lipidomics, we utilised an LTQ-Orbitrap XL (ThermoFisher Scientific) coupled with a TriVersa NanoMate (Advion Biosciences), following established methods (Nielsen, 2017). Lipids are identified by product-ion scan MS
n analyses, targeting PE, PEo, and PEp species for quantification against an internal standard. PEp specie identification was confirmed by MS
n analysis (Hsu, 2018) and sensitivity to acid hydrolysis (Han, 2005).
Our preliminary data demonstrates that PEp levels and fatty acid composition play a role in synapse formation, with further experiments being implemented to investigate underlying mechanisms. We are currently developing further our shotgun lipidomics approach to employ data-independent acquisition and incorporate a range of internal standards to enable identification and quantitation of the global lipidome.
Deprescribing bisphosphonates in the osteoporosis treatment in older people
Authors: Dudinskaya E. N. , Malaya I. P. 
Published: June 2024

The term deprescribing (de-prescribe) means the abolition of appointments. In the modern researches, deprescribing is presented as a planned and controlled process of dose reduction or drug cessation, which can potentially harm the patient and/or does not benefit the patient. The target population for deprescribing is the older people, as old age and limited life expectancy are themselves reasons to try to reduce and optimize the drug load. Frailty syndrome or dementia, decreased kidney function and comorbidity are expected to coexist with polypragmasy and inconsistent appointments of different specialists. In foreign and domestic scientific studies there are manuals and recommendations on deprescribing of various groups of drugs for the elderly and seniors: proton pump inhibitors, sugary drugs, psychotropic drugs and others. However, with regard to osteoporosis drug therapy, the concept of deprescribing is debated rather sparingly, despite the possible serious side effects of osteoporosis treatment in the older age group.The review presents data from small clinical studies and systematic reviews describing deprescribing antiosteoporotic drugs from the bisphosphonate group, the reasons for their withdrawal and its consequences for the elderly and seniors with osteoporosis, as well as the analysis of tools for optimizing pharmacotherapy in elderly and seniors with respect to deprescribing of bisphosphonates.
Surrogate markers in assessment of bisphosphonate effectiveness in osteoporosis treatment (bone mineral density, bone turnover markers)
Authors: Belaya Zh. E. , Rozhinskaya L. Ya. 
Published: June 2024

A review of the literature which summarizes our knowledge on the use of surrogate markers of the osteoporosis treatment effectiveness when on bisphosphonate (BP) therapy. Bone mineral density (BMD) and markers of bone turnover, which have been shown to be associated with the clinical fracture end point, have been used as surrogate criteria for the effectiveness of treatment of osteoporosis in randomized controlled trials. When prescribing BP for the treatment of osteoporosis, BMD measurement every 12 months by dual-energy x-ray absorptiometry (DXA) is the well-described surrogate marker of BP efficacy. At the same time, stabilization of BMD is also a criterion for the treatment effectiveness since changes in BMD determined only 16% of the anti-fracture effectiveness of BP. Markers of bone remodeling can be used as surrogate markers after 3 (bone resorption) or 6 (bone formation) months from the start of BP therapy. A decrease of 30% or more is considered to be prognostically effective for both antifracture and BMD gain. There is a direct relationship between the degree of bone remodeling markers decrease and the antifracture effectiveness of BP therapy. The decrease in markers persists throughout the entire period of therapy and, accordingly, they can be used as surrogate markers of effectiveness and adherence to BP therapy throughout the entire treatment period. However, the presence of pathological fractures is a key clinical manifestation of osteoporosis and should be considered first in every decision making compared to any surrogate marker.Thus, when prescribing BP treatment, surrogate markers of changes in BMD and/or markers of bone remodeling can be used to monitor the effectiveness of treatment throughout the entire period of treatment and patients’ monitoring.
Gamificación como estrategia para incluir la educación ambiental en el contexto universitario: caso REHI
Authors: Marlés Betancourt Claritza , Peña Torres Parcival , Pardo Rozo Yelly Yamparli 
Published: June 2024

Este artículo describe una experiencia de innovación educativa en el aula mediante el diseño de un juego de mesa como alternativa didáctica para introducir la educación ambiental en el contexto universitario. Esta experiencia considera las realidades ambientales de los recursos hídricos y el impacto que genera el ser humano sobre ellos. Se presenta una investigación aplicada en el campo educativo, con enfoque mixto y fases metodológicas de la investigación basada en diseño, que aborda la construcción colectiva del juego Reduce tu huella hídrica con un grupo semilla a través del design thinking y la gamificación. En las distintas fases de desarrollo participaron 106 estudiantes de la Universidad de la Amazonía, elegidos a través de un muestreo no probabilístico. Entre los resultados se destaca la sensibilización ambiental de los participantes respecto a los recursos hídricos en la fase de implementación, con una valoración positiva en cuanto a la apropiación percibida del conocimiento, la importancia del tema en la región, las dinámicas del juego en términos de su capacidad para motivar cambios actitudinales y la importancia metodológica de la gamificación en el desarrollo de competencias genéricas como el trabajo en equipo, la creatividad y la comunicación. El juego de mesa diseñado representa una alternativa didáctica participativa y flexible que contribuye desde la academia a la construcción de una cultura hídrica en el piedemonte amazónico colombiano.
Si metasurface supporting multiple quasi-BICs for degenerate four-wave mixing
Authors: Moretti Gianni Q. , Weber Thomas , Possmayer Thomas , Cortés Emiliano , Menezes Leonardo de S. , Bragas Andrea V. , Maier Stefan A. , Tittl Andreas , Grinblat Gustavo 
Published: June 2024

Abstract
Dielectric metasurfaces supporting quasi-bound states in the continuum (qBICs) enable high field enhancement with narrow-linewidth resonances in the visible and near-infrared ranges. The resonance emerges when distorting the meta-atom’s geometry away from a symmetry-protected BIC condition and, usually, a given design can sustain one or two of these states. In this work, we introduce a silicon-on-silica metasurface that simultaneously supports up to four qBIC resonances in the near-infrared region. This is achieved by combining multiple symmetry-breaking distortions on an elliptical cylinder array. By pumping two of these resonances, the nonlinear process of degenerate four-wave mixing is experimentally realized. By comparing the nonlinear response with that of an unpatterned silicon film, the near-field enhancement inside the nanostructured dielectric is revealed. The presented results demonstrate independent geometric control of multiple qBICs and their interaction through wave mixing processes, opening new research pathways in nanophotonics, with potential applications in information multiplexing, multi-wavelength sensing and nonlinear imaging.
A review on modeling of graphene and associated nanostructures reinforced concrete
Authors: Yue Qiang , Wang Qiao , Rabczuk Timon , Zhou Wei , Chang Xiaolin , Zhuang Xiaoying 
Published: June 2024

Abstract
Concrete is the most popular construction material in infrastructure projects due to its numerous natural advantages. Nevertheless, concrete constructions frequently suffer from low tensile strength and poor durability performance which are always urgent tasks to be solved. The concrete reinforced by various nanomaterials, especially graphene and its associated nanostructures (GANS), shows excellent chemical and physical properties for engineering applications. The influence of GANS on cement composites is a multiscale behavior from the nanoscale to the macroscale, which requires a number of efforts to reveal via numerical and experimental approaches. To meet this need, this study provides a comprehensive overview of the numerical modeling for GANS reinforced concrete in various scales. The background and importance of the topic are addressed in this study, along with the review of its methodologies, findings, and applications. Moreover, the study critically summarizes the performance of GANS reinforced concrete, including its mechanical behavior, transport phenomena, and failure mechanism. Additionally, the primary challenges and future prospects in the research field are also discussed. By presenting an extensive overview, this review offers valuable insights for researchers and practitioners interested in numerical simulation to advance concrete science and engineering.
Knee Extensor Apparatus Reconstruction with Allograft after Patellar Resection: A Case Report
Authors: Cosseddu Fabio , Cordoni Martina , Bechini Elena , Ipponi Edoardo , Campo Francesco Rosario , D'Arienzo Antonio , Andreani Lorenzo 
Published: June 2024

Background: The extensor apparatus of the knee can be thought of a chain that transmits the muscular strength developed by the quadriceps muscles to the proximal tibia. This complex is essential to allow the extension of the tibia over the femur, being essential to provide knee mobility and stability. In case of lesions which irreparably damage the patella, such as a locally aggressive bone tumor, it is necessary to restore both the apparatus’ anatomical continuity and its strength.Case report: A 39-years-old Caucasian man with a history of lung carcinoma developed atraumatic swelling and soreness in his left knee. Imaging evidence reported a degeneration of the left patella. We performed an en bloc resection of the patella and the nearby soft tissues of the extensor apparatus. The resulting gap was fulfilled with a massive allograft consisting of a quadriceps tendon, a patella and a patellar ligament. No complication or local recurrences were observed. At the patient’s latest follow-up, he did not have any extension lag and quadriceps strength was completely restored.Conclusion: Massive allografts can represent a reliable alternative for the reconstruction of the patella and the knee extensor apparatus in orthopedic oncology.
Дослідження форм гемоглобіну за умов споживання енергетичного напою
Authors:   Ivano-Frankivsk National Medical University, 2 Halytska str., Ivano-Frankivsk, 76018, Ukraine, Partsei Kh. Yu. , Ersteniuk H. M. ,   Ivano-Frankivsk National Medical University, 2 Halytska str., Ivano-Frankivsk, 76018, Ukraine
Published: June 2024

In today’s world, where stress and busyness are an integral part of everyday life, energy drinks have become not only a means of satisfying the need for energy and maintenance of vitality, but also a symbol of lifestyle, an important element of the modern culture of consumption. The speed and efficiency they promise attract the attention of consumers, especially those who are constantly on the move. Such drinks have become popular not only among young people, but also among everyone who seek to maintain their activity and efficiency during the day. The purpose of the work was to investigate the dynamics of changes in the level of total hemoglobin and its forms, in particular oxy-, carboxy-, sulf-, met-, and dyshemoglobin under the conditions of energy drink consumption. The study was conducted using male Wistar rats weighing 150–220 g kept in the vivarium under appropriate lighting conditions, temperature, humidity and standard diet. All the animals had free access to feed (based on daily requirements) and water (based on 20 ml of water per rat per day). The experiment was carried out in compliance with the requirements of the European Convention for the Protection of Vertebrate Animals used for Experimental and Scientific Purposes (Strasbourg, 1986). The animals were divided into five groups: the 1st group received drinking water (intact control); the 2nd–5th groups received daily the non-alcoholic energy drink “Burn” per os for a month. The calculation of the required amount of drink for administration per one rat was based per 1 kg of body weight. To monitor the growth and development, we weighted the rats at the beginning and at each stage of the experiment. The material (blood) was taken on the 1st (2nd group), 10th (3rd group), 20th (4th group) and 30th day (5th group) after the completion of the experiment under anesthesia (intramuscularly sodium thiopental, 60 mg/kg). The total hemoglobin level was determined with the Mythic 18 hematological analyzer. Determination of the content of oxyhemoglobin, methemoglobin, sulfhemoglobin and carboxyhemoglobin was performed spectrophotometrically. The obtained data indicate significant changes in both the total level of hemoglobin and its ligand forms, in particular, a decrease in the level of oxyhemoglobin and the accumulation of dyshemoglobins, such as methemoglobin, sulfhemoglobin, and carboxyhemoglobin. As evidenced by the obtained results, the consumption of energy drinks leads to the oxygen homeostasis violation, the development of tissue hypoxia and can cause structural and functional disorders in the body under such conditions.
Концептуализация транспозиции в семиотике литературы Ю. М. Лотмана
Authors: Кроо Каталин 
Published: June 2024

В статье изучается семиотическое явление транспозиции, предпринимается попытка разработать его понятийное определение и описаниe в общих рамках семиотики культуры и, в частности, в се-миотике литературы Юрия Лотмана.Если понятие транспозиции в семиотике культуры входит в такие области научного исследования как трансмедийность, переводоведение, интертекстуальность, интердискурсивность, интерсемио-тика, то в семиотике литературы Лотмана транспозиция концептуализирована – непосредственно или через опосредование без превращения самого термина «транспозиция» в ключевой – в окру-жении и свете таких понятий как граница; контекст – в вариантах: «контекстные структуры», «кон-структивные контексты», «семантические структуры»; семантическая «упорядоченность» (в том числe и «частичная» и «дополнительная»); условность; бинарность и плюральность; множество и «подмножество» / «субсемиосфера»; семиосфера и т. д.Перечень составляющих понятийного фона для изучения транспозиции в литературно-семио-тическом понимании Лотмана сам по себе свидетельствует о том, что исследование в данном на-правлении приводит к выяснению экстенсивного терминологического поля и органических вза-имосвязей элементов внутри него. С другой стороны, прослеживание данных понятий на основе многочисленных текстов (oт работы «О разграничении лингвистического и литературоведческого понятия структуры», через «Структуру художественного текста», до работ 90-х годов), возникаю-щих по ходу эволюции научного достижения ученого, позволяет подчеркнуть когерентность теоре-тической работы, относящейся к так называемым «структуралистскому» и «постструктуралистко-му» периодам его мышления.Толкование в статье согласованности понятий Лотмана в разнообразных его подходах к лите-ратурному тексту, ориентированных на понимание внутри- и внетекстовых форм культурного общения, в котором литература участвует в разных измерениях, позволяет видеть транспозицию в понимании ученого как гарантий текстовой динамики. Текстовая динамика в смысле порождения нового смысла толкуется в статье в свете операций дифференциации в ракурсах принципов реля-ционности и взаимопроекций определенных микро- / макроэлементов и -контекстов, а также смен их упорядоченностей. Эти смены воплощают транспозиции, несущие смысловые трансформации и приводящие к возникновению новых семиотических условностей.Транспозиция в итоге осмысляется как семантический генератор, касающийся в семиотике ли-тературы Лотмана толкования события в качестве «перемещения персонажа через границу семан-тического поля»; оформления семантического сюжета; умножения бинарностей, превращающихся в составляющие плюральных формаций; развития семиотических условностей в поэтике литера-турного текста и метадискурсивности литературы.