bluuebunny/crossref_metadata_2025_split huggingface dataset:
Students’ Interest Towards Physical EducationCabilao National High SchoolCabilao, Loon, Bohol
Authors: Carlon Lesley Anne , Vidal L. Platino, Jr. Vidal 
Published: February 2025

This quantitative-descriptive study examines the factors that affect the interest of 107 Senior High School students in physical education at Cabilao National High School, Loon, Bohol, Philippines. The study utilizes a revised questionnaire created by Kate Sauer to investigate the relationships among factors including age, sex, academic strand, grade level, teacher performance, peer influence, and self-perception in relation to students' interest. The findings revealed a significant correlation between grade level and students' interest. On the other hand, characteristics such as age, sex, and academic strand showed no significant correlation. Furthermore, the findings show that, while children have a favorable interest in physical education, it does not have a substantial association with their academic performance. The study emphasizes the critical role of educators in increasing student engagement and the relevance of using interactive and relevant teaching approaches. It highlights the need of developing a positive attitude toward physical education in order to encourage long-term participation in physical activities.
Terrible Triad Injury in a Skeletally Immature Patient
Authors: Lavoie-Gagné Ophélie , de Klerk Huub , Tuaño Krystle R. , Bhashyam Abhiram R. 
Published: February 2025

Case:
A 7-year-old girl presented with an elbow terrible triad injury (coronoid fracture, Salter-Harris IV radial head fracture, and lateral collateral ligament avulsion) diagnosed after magnetic resonance imaging was obtained to evaluate subtle subluxation on radiographs. The patient underwent physeal-sparing fixation using the anconeus-extensor carpi ulnaris interval. One year postoperatively, she had full, stable symmetric range of motion compared with the contralateral side without complication.

Conclusion:
Pediatric terrible triad injuries are rare, are easily missed, and have poor results after late reconstruction. Subtle radiographic abnormalities may benefit from evaluation with advanced imaging since early diagnosis and treatment can lead to excellent results as demonstrated in this case.
The needs, preferences, and experiences of LGBT+ people living with dementia: A systematic review with thematic synthesis
Authors: Chidiac Claude , Walshe Catherine , Lowers Jane , Preston Nancy 
Published: February 2025

Abstract

Background
LGBT+ people are disproportionately at an increased risk for developing dementia. Dementia can compound the impact of stigma and social marginalisation experienced by LGBT+ people, and is likely to create barriers to accessing healthcare services. Understanding the needs, preferences, and experiences of LGBT+ people with dementia will help support high quality individualised care. The aim of this review is to explore and synthesise the evidence on the needs, preferences, and experiences of LGBT+ people with dementia.
Methods
Systematic review with thematic synthesis. The search strategy combined concepts of gender and sexual minorities, and dementia. MEDLINE Complete, PsycInfo, CINHAL, and Academic Search Ultimate were searched until March 2024. Relevant published papers in the English language were included, regardless of design or type. Data were analysed using thematic analysis.
Results
Out of 1537 initial titles, 17 papers were included. Majority were published in the UK (n=8), followed by USA (n=5), Canada (n=2), and Australia (n=2). Of 17 papers, two were empirical qualitative studies, one was empirical quantitative study, one used a subset of qualitative data from a previous study alongside other sources (literature review, reflection, policy) for data analysis, and 13 papers were non-empirical. Four themes were identified:
1. Oppression, discrimination, and stigmatisation of the present are compounded by the past
2. Maintaining personhood: The intersection of an LGBT+ identity and dementia
3. Access to love, intimacy, and social networks act as a buffer to the added stressors
4. ‘Outed by dementia’: Safety and control in identity disclosure and expression
Conclusion
The robustness of the science is weak regarding the needs, preferences, and experiences of LGBT+ people with dementia. Designing and implementing dementia related policies through a queer intersectional lens, alongside embedded cultural safety education programmes are needed. Further research that includes the voice of LGBT+ people with dementia coupled with healthcare professionals’ perspective is needed.
Anesthetic management of a complex spine surgery in a thalassemia patient: a path less travelled!
Authors: Naz Anjum , Sarkar Soumya , Dandapat Saswat 
Published: February 2025

Abstract

Spinal extramedullary hematopoiesis (EMH) a rare complication of Hb E/β-thalassemia can result in compressive myelopathy, posing serious neurological risks, particularly in the thoracic spine. We present the case of a 32-year-old male with Hb E/β-thalassaemia who developed spastic paraplegia due to compressive myelopathy from thoracic epidural EMH refractory to radiotherapy. The patient had severe hypochromic microcytic anemia (Hb 7.3 g/dL), elevated serum iron, and significant spinal canal narrowing from D4-D10 on MRI. The patient underwent surgical decompression under general anesthesia with special considerations, including careful airway management, prone positioning, and restrictive transfusion protocols to avoid increased blood viscosity and exaggerated hemolysis. This case highlights the multifaceted challenges of managing thoracic EMH in Hb E/β-thalassaemia, including ineffective erythropoiesis, hypercoagulability, and anemia. The use of tranexamic acid plays a key role in reducing the amount of intraoperative bleeding and mitigating the risk of hyperfibrinolysis in a prothrombotic condition. The Individualized anesthetic and surgical strategies were crucial for significant neurological recovery and improved quality of life of the patient.
De Novo Design and Evolution of an Artificial Metathase for Cytoplasmic Olefin Metathesis
Authors: Ward Thomas , Zou Zhi , Kalvet Indrek , Lozhkin Boris , Morris Elinor , Zhang Kailin , Chen Dongping , Ernst Marco , Zhang Xiang , Baker David 
Published: February 2025

Abstract

Artificial metalloenzymes (ArMs) present a promising avenue for abiotic catalysis within living systems. However, their in vivo application is currently limited by critical challenges, particularly in selecting suitable protein scaffolds capable of binding abiotic cofactors and maintaining catalytic activity in complex media. Herein, we address these limitations by introducing an artificial metathase—an artificial metalloenzyme designed for ring-closing metathesis (RCM)— for whole cell biocatalysis. Our approach integrates a tailored metal cofactor into a hyper-stable, de novo designed protein. By combining computational design with genetic optimization, a binding affinity (KD ≤ 0.2 μM) between the protein scaffold and cofactor is achieved through supramolecular anchoring. Directed evolution of the artificial metathase yielded variants exhibiting excellent catalytic performance (TON ≥ 1000) and biocompatibility. This work represents a pronounced leap in the de novo design and in vivo engineering of artificial metalloenzymes, paving the way for abiological catalysis in living systems.
Solo or team? A meta-analysis of individual vs. group-based studies on physical activity, functional, psychosocial, and health outcomes.
Authors: Kritz Marlene , Ridell Ηugh , Olsen Daryn , Harden Samantha , Burke Shauna , Ntoumanis Nikos , Thøgersen-Ntoumani Cecilie 
Published: February 2025

Abstract

Social influences, such as group dynamics, social norms, and peer support are assumed to influence physical activity (PA). Burke et al. (2006) found that “true groups” (i.e., those using group dynamics principles) had advantages over other group conditions in terms of PA. Given technological advances and the rise of virtual exercise platforms, we aimed to update and extend these findings. We conducted a meta-analysis of 71 studies (523 effect sizes), primarily experimental (95%), comparing individual and group-based PA conditions on outcomes including PA levels, functional assessments (e.g., flexibility, strength), psychosocial measures (e.g., quality of life, loneliness), and health indices (e.g., body mass index). Using a three-level random-effects model, group-based conditions showed a small but non-significant advantage over individual conditions for PA (g = .071, p = .642), psychosocial (g = .292, p = .214), and health outcomes (g = .125, p = .096). For functional outcomes, a small but significant advantage for groups emerged after outlier removal (g = .164, p = .015). Moderation analysis showed that different types of groups resulted in similar outcomes. The only exception was for “true groups”, whose effect size predicting health outcomes was larger compared to the effect sizes for other group types. Both individual and group -based approaches (in-person or online) may be effective for PA promotion. Future research should explore the underlying mechanisms that optimise each approach for specific populations and settings.
Review registration: Registered on PROSPERO (CRD42021271452)
Case Study Based on Strategic Analysis: Preparation for Industry 4.0 and Process Improvement in a Thermoplastic Company
Authors: Santo Cleiviane Aparecida Nogueira , Pacheco Dulcineves Ferreira , Ferreira Ananda Katharyne Bentes , Gonçalves Daniela Carneiro , Menezes Mauricio Lima de , Santiago Sandro Breval 
Published: February 2025

Objective: This study analyzes how preparation for Industry 4.0 and process improvements affect a thermoplastic company in the Industrial Hub of Manaus. It focuses on the relationship between "Manufacturing and Operations" and "Supply Chain." The goal is to evaluate their impact on operational efficiency.

Theoretical Framework: The theoretical framework highlights the importance of organizational maturity, logistics, automation, and IoT for thermoplastic industries in Industry 4.0, as well as the use of strategies such as QRM and PCP to optimize inventory and reduce costs.

Method: The study employed a mixed and descriptive approach, along with triangulation for analysis. Data were collected from the PIMM 4.0 system and analyzed using JASP software.

Results and Discussion: The analysis results indicate that the "Industry 4.0" variable may have a more significant impact on operational efficiency compared to other variables. However, when compared to “use of data in manufacturing,” “real-time inventory,” and “lead time,” the results were insufficient to clearly determine operational efficiency.

Research Implications: The study showed that preparation for Industry 4.0 and operational variables, on their own, do not significantly impact the efficiency of thermoplastic industries. It emphasizes the need for integrated strategies to overcome the challenges of technological adoption.

Originality/Value: The study examines Industry 4.0 readiness in the thermoplastic sector using a mixed methodology and Multiple Linear Regression with Stepwise. It highlights the importance of contextual factors and integrated approaches in strategic planning.
Desain Pendidikan Karakter Demokratis Pada Pembelajaran PPKn Kelas V SD Muhammadiyah 1 Candi Labschool UMSIDA
Authors: Setyowati Erni Sulis , Kurniawan Machful Indra 
Published: February 2025

Desain pendidikan karakter yang diterapkan dalam pembelajaran PPKn bertujuan untuk mewujudkanserta menanamkan karakter demokratis dalam diri peserta didik, sesuai dengan norma yang ada pada kehidupan sekitar. Metode penelitian yang digunakan dalam penelitian dan pengembangan research and Development (R&D) menggunakan model 4D yakni dikutip dari Thiagarajan, (1974) menjadi 4 tahap pengembangan. Tahap pertamaÂ Define (Pendefinisian), kedua Design, ketiga Develop, danÂ keempat Dessminate (Penyebaran). Pada hasil penelitian menunjukan tahap pendefinisian kurang adanya inovatif dalam penyampaian materi pembelajaran PPKn sehingga peserta didik akan merasa jenuh dengan pembelajaran, perangkat pembelajaran yang belum adanya pembahuruan dengan kurikulum terbaru dan pada perangkat pembelajaran tersebut kurangnya kegiatan pembelajaran yang direncanakan dan kondisi peserta didik yang menunjukan bahwa kurangnya rasa keingin tahuan dalam dirinya. Tahap perancangan dalam menyusun perangkat pembelajaran secara kontekstual, dan penyesuaian materi yang disampaikan.Tahap pengembangan perangkat pembelajaran dilakukan pengembangan dengan memberikan variasi dalam setiap pertemuan pada pembelajaran. Dan tahap penyebaran melalui 3 tahapan yakni tes validasi pada validator ahli, divisi penafsiran dari sebuah lembaga pendidikan terhadap perangkat pembelajaran, dan berdasarkan pengembangan instruksional model 4D memasuki tahap adopsi pada perangkat pembelajaran yang telah dirancang dan dikembangkan dalam penerapan pembelajaran PPKn.Upaya tersebut terus dilaksanakan karena pada abad ke-21 ini apabila tidak seimbang antara perkembangan zaman dengan pendidikan karakter maupun moral akan mengakibatkan terjerumusnya peserta didik dalam ajaran yang salah
Profil PROFIL KETERAMPILAN TEKNOLOGI INFORMASI DAN KOMUNIKASI GURU SEKOLAH DASAR DALAM IMPLEMENTASI KURIKULUM MERDEKA DI BANYUWANGI
Authors: Solipyani  , Sunardi  , Farizi Imam 
Published: February 2025

Penelitian ini bertujuan untuk mendeskripsikan keterampilan teknologi informasi dan komunikasi (TIK) guru alam implementasi kurikulum merdeka di gugus 3 Yosomulyo kecamatan Gambiran Kabupaten Banyuwangi. Keterampilan TIK ini menjadi penting untuk mendukung implementasi kurikulum merdeka yang terintegrasi dengan platform merdeka mengajar. Pada penelitian ini, metode yang digunakan adalah deskriptif kualitatif yang pengumpulan data menggunakan teknis angket,, wawancara dan observasi. Responden penelitian terdiri dari enam guru dari tiga sekolah di gugus 3 Yosomulyo Kecamatan Gambiran Kabupaten Banyuwangi. Data yang diperoleh selanjutnya dianalisis melalui proses reduksi, penyajian, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa sebagian besar guru memiliki keterampilan yang baik dalam mengoperasikan computer, memanfaatkan aplikasi perangkat lunak, memanfaatkan internet, dan memanfaatkan laman website untuk mendukung proses pembelajaran. Keterampilan guru-guru dalam aspek tersebut dianggap memadai untuk menunjang implementasi Kurikulum Merdeka di Sekolah Dasar. Hasil penelitian ini diharapkan dapat menjadi acuan bagi pengembangan profesionalisme guru dalam pemanfaatan TIK di sekolah.

Kata kunci : Keterampilan teknologi informasi dan komunikasi; Guru Sekolah Dasar; Kurikulum Merdeka
HUBUNGAN ANTARA SELF EFFICACY DENGAN LITERASI DIGITAL TERHAPAD MOTIVASI BELAJAR SISWA KELAS V SEKOLAH DASAR
Authors: Ramadhani Afifah Dwi , Habibi Mhmd 
Published: February 2025

Penelitian ini bertujuan untuk memahami bagaimana efikasi diri dan literasi digital siswa kelas V SDIT Al-Fityah Pekanbaru. Urgensi efikasi diri adalah dapat memengaruhi cara seseorang berpikir, bertingkah laku, merasakan, dan memotivasi dirinya sendiri. Populasi dalam penelitian ini berjumlah sembilan puluh siswa kelas V, dibagi menjadi tiga kelas. teknik sampling dalam penelitian ini adalah purposive sampling dengan jumlah sampel 30 siswa di kelas V A. Metode penelitian ini adalah kuantitatif, dengan teknik analisis menggunakan uji t. hasil penelitian menunjukkan motivasi belajar siswa dan literasi digital terbukti berkorelasi secara signifikan, berdasarkan hasil uji-t untuk variabel efikasi diri dan literasi digital. Uji koefisien determinasi (R2) menunjukkan bahwa efikasi diri dan literasi digital bersama-sama menyumbang 45,9% motivasi belajar siswa kelas V SDIT Al-Fityah Pekanbaru.
Patrones Grasp y Anti-Patrones: un Enfoque Orientado a Objetos desde Lógica de Programación
Authors: Botero Tabares Ricardo 
Published: February 2025

This article presents a teaching strategy for introducing the use of patterns GRASP (General Responsibility Assignment Software Patterns) and the disuse of anti-design patterns in the course “fundamentals object-oriented programming”, where problems are solved according to four phases: identification of requirements, design class diagram, specification of responsibilities and pseudocode writing.
Caracterización Del Proceso De Producción De Tableros Alistonados En Pereira Y Dosquebradas
Authors: Londoño Echeverri Carlos Andrés 
Published: February 2025

From a research project registered in the UCPR Research Center, this article presents the study results on current techniques in the manufacturing process of edge-glued panels, as well as the technology used for the wood and furniture regional industry in the handling and disposal of the wood laths (raw material) and edge-glued panels. In addition, it is analyzed a different way of working with wood as an alternative for the regional industry, considering that not only adequate mechanical properties are achieved, which are higher than normal wood, but also itis possible to provide aesthetic value of wood products.
Memory CD4+ T cells sequentially restructure their 3D genome during stepwise activation
Authors: Ward Alexander I. , de las Heras Jose I. , Schirmer Eric C. , Fassati Ariberto 
Published: February 2025

BackgroundCD4+ T cells are a highly differentiated cell type that maintain enough transcriptomic plasticity to cycle between activated and memory statuses. How the 1D chromatin state and 3D chromatin architecture support this plasticity is under intensive investigation.MethodsHere, we wished to test a commercially available in situ Hi-C kit (Arima Genomics Inc.) to establish whether published performance on limiting cell numbers from clonal cell lines copies across to a primary immune cell type. We achieved comparable contact matrices from 50,000, 250,000, and 1,000,000 memory CD4+ T-cell inputs. We generated multiple Hi-C and RNA-seq libraries from the same biological blood donors under three separate conditions: unstimulated fresh ex vivo, IL-2-only stimulated, and T cell receptor (TCR)+CD28+IL-2-stimulated, conferring increasingly stronger activation signals. We wished to capture the magnitude and progression of 3D chromatin shifts and correlate these to expression changes under the two stimulations.ResultsAlthough some genome organization changes occurred concomitantly with changes in gene expression, at least as many changes occurred without corresponding changes in expression. Counter to the hypothesis that topologically associated domains (TADs) are largely invariant structures providing a scaffold for dynamic looping contacts between enhancers and promotors, we found that there were at least as many dynamic TAD changes. Stimulation with IL-2 alone triggered many changes in genome organization, and many of these changes were strengthened by additional TCR and CD28 co-receptor stimulation.ConclusionsThis suggests a stepwise process whereby mCD4+ T cells undergo sequential buildup of 3D architecture induced by distinct or combined stimuli likely to “prime” or “deprime” them for expression responses to subsequent TCR-antigen ligation or additional cytokine stimulation.
Diagnostic accuracy of methylated SEPT9 for primary liver cancer: a systematic review and meta-analysis
Authors: Jin Danwen , Qian Liyong , Chen Jiayao , Yu Ze , Dong Jinliang 
Published: February 2025

BackgroundPrimary live cancer (PLC), including hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). This meta-analysis was conducted to evaluate the diagnostic efficacy of blood methylated septin 9 gene (mSEPT9) for PLC and to analyze its performance across various subgroups.MethodsWe conducted a comprehensive search across PubMed, the Cochrane Library, Embase, and China National Knowledge Infrastructure (CNKI), covering research up to May 10, 2024. The pooled sensitivity, specificity, diagnostic odds ratios, and area under the summary receiver operating characteristic (AUC) were calculated for the diagnostic performance of mSEPT9 for PLC. The quality of the studies was assessed using the QUADAS-2 tool, and the meta-analysis was performed using Stata16.0 software.ResultsTen articles with 2,182 participants were included in the meta-analysis. The pooled sensitivity of mSEPT9 for detecting primary liver cancer was 0.51 (95% confidence interval [CI]: 0.37-0.65), and the pooled specificity was 0.93 (95% CI: 0.78-0.98). The pooled diagnostic odds ratio was 13 (95% CI: -58), and the area under the Summary Receiver Operator Characteristic Curve was 0.75 (95% CI: 0.71-0.79). Subgroup analyses showed that ICC, case-control studies, qPCR and Asian populations had higher specificities (0.99 [95% CI: 0.97–1.00], 0.93 [95% CI: 0.91-0.95], 0.90 [95% CI: 0.88-0.92] and 0.94 [95% CI: 0.92-0.96], respectively) and diagnostic odds ratios (62.04 [95% CI: 6.53-589.53], 17.62 [95% CI: 4.03-76.99], 13.03 [95% CI: 2.01-84.63] and 14.19 [95% CI: 2.42-83.11], respectively) compared to hepatocellular carcinoma, cohort Study, and Euramerican populations.ConclusionsThis study confirmed that mSEPT9 in blood has high specificity and moderate sensitivity for detecting primary liver cancer. The diagnostic performance of mSEPT9 varied across different subgroups, limiting its use as an independent screening tool and necessitating its use in conjunction with other methods for confirmatory diagnostics.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024549669.
Rheumatoid arthritis-associated rheumatoid factors post-COVID-19
Authors: Titi Adam H. , Krisko Braedon T. , Bashar S. Janna , Adyniec Ryan R. , Parker Maxwell H. , Murren Nat F. , Myhr Courtney B. , Shelef Miriam A. 
Published: February 2025

ObjectiveRheumatoid factors (RFs) are a hallmark of rheumatoid arthritis but also arise in infections, including COVID-19. Moreover, infections, again including COVID-19, are associated with rheumatoid arthritis development, positioning RFs as a potential link between infection and rheumatoid arthritis. RFs traditionally have been thought to be relatively uniform in their reactivity across conditions apart from some increased reactivity in rheumatoid arthritis. Recently, however, IgG RFs that bind citrulline- and homocitrulline-containing IgG epitopes were identified in rheumatoid arthritis, but not other autoimmune diseases, whereas IgM RFs that bind specific native linear IgG epitopes were found uniquely post-COVID-19. The objective of this study was to determine if rheumatoid arthritis-associated RFs develop post-COVID-19 in order to provide new insights into post-infection immune tolerance loss.MethodsCOVID-19 convalescent, rheumatoid arthritis, and control sera (n=20) were used in enzyme-linked immunosorbent assay to evaluate IgG, IgM, and IgA binding to eight IgG1-derived peptides in their native, citrulline-containing, and homocitrulline-containing forms. Antibody levels were compared by Kruskal-Wallis test with Dunn’s multiple comparisons test, and the number of participants with binding greater than all controls was compared by Fisher’s exact test.ResultsIgG binding to seven of the eight IgG1-derived peptides was increased in a citrulline- or homocitrulline-specific manner only in rheumatoid arthritis. IgA binding was increased to five of eight IgG1-derived peptides in a citrulline- or homocitrulline-specific manner in rheumatoid arthritis and to one homocitrulline-containing peptide post-COVID-19. More post-COVID-19 participants than controls had elevated IgG or IgA binding to two IgG1-derived peptides in a homocitrulline-specific manner.ConclusionRheumatoid arthritis-associated RFs are primarily restricted to rheumatoid arthritis, but some individuals post-COVID-19 generate moderate levels of a few rheumatoid arthritis-associated RFs, especially of the IgA isotype and homocitrulline-reactive. These findings refine our understanding of RFs, provide novel insights into loss of immune tolerance post-infection, and reveal new possibilities for biomarker development in preclinical rheumatoid arthritis.