bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex and gender differences in adverse events following influenza and COVID-19 vaccination
Authors: Yin Anna , Wang Nadia , Shea Patrick J. , Rosser Erica N. , Kuo Helen , Shapiro Janna R. , Fenstermacher Katherine Z.J. , Pekosz Andrew , Rothman Richard E. , Klein Sabra L. , Morgan Rosemary 
Published: June 2024

Abstract
Introduction
Active and passive surveillance studies have found that a greater proportion of females report adverse events (AE) following receipt of either the COVID-19 or seasonal influenza vaccine compared to males. In a predominately young adult female population of healthcare workers, we sought to determine the intersection of biological sex and sociocultural gender differences in prospective active reporting of vaccine outcomes, which remains poorly characterized.

Methods
This cohort study enrolled Johns Hopkins Health System healthcare workers (HCWs) who were recruited from the mandatory annual fall 2019–2022 influenza vaccine and the fall 2022 COVID-19 bivalent vaccine campaigns. Vaccine recipients were enrolled the day of vaccination and AE surveys were administered two days post-vaccination for bivalent COVID-19 and influenza vaccine recipients. Data were collected regarding the presence of a series of solicited local and systemic AEs. Open-ended answers about participants’ experiences with AEs also were collected for the COVID-19 vaccine recipients.

Results
Females were more likely to report local AEs after either influenza (OR = 2.28, p = 0.001) or COVID-19 (OR = 2.57, p = 0.008) vaccination compared to males, regardless of age or race. Males and females had comparable probabilities of reporting systemic AEs after either influenza (OR = 1.18, p = 0.552) or COVID-19 (OR = 0.96, p = 0.907) vaccination. Hormonal birth control use did not impact the rates of reported AEs following influenza vaccination among reproductive-aged female HCWs. Women reported more interruptions in their daily routine following COVID-19 vaccination than men and were more likely to seek out self-treatment. More women than men scheduled their COVID-19 vaccination before their days off in anticipation of AEs.

Conclusions
Our findings highlight the need for sex- and gender-inclusive policies to inform more effective mandatory occupational health vaccination strategies. Further research is needed to evaluate the potential disruption of AEs on occupational responsibilities following mandated vaccination for healthcare workers, a predominately female population, and to more fully characterize the post-vaccination behavioral differences between men and women.
Estimating the first and second derivatives of discrete audio data
Authors: Lewandowski Marcin 
Published: June 2024

AbstractA new method for estimating the first and second derivatives of discrete audio signals intended to achieve higher computational precision in analyzing the performance and characteristics of digital audio systems is presented. The method could find numerous applications in modeling nonlinear audio circuit systems, e.g., for audio synthesis and creating audio effects, music recognition and classification, time-frequency analysis based on nonstationary audio signal decomposition, audio steganalysis and digital audio authentication or audio feature extraction methods. The proposed algorithm employs the ordinary 7 point-stencil central-difference formulas with improvements that minimize the round-off and truncation errors. This is achieved by treating the step size of numerical differentiation as a regularization parameter, which acts as a decision threshold in all calculations. This approach requires shifting discrete audio data by fractions of the initial sample rate, which was obtained by fractional delay FIR filters designed with modified 11-term cosine-sum windows for interpolation and shifting of audio signals. The maximum relative error in estimating first and second derivatives of discrete audio signals are respectively in order of$$10^{-13}$$10-13and$$10^{-10}$$10-10over the entire audio band, which is close to double-precision floating-point accuracy for the first and better than single-precision floating-point accuracy for the second derivative estimation. Numerical testing showed that this performance of the proposed method is not influenced by the type of signal being differentiated (either stationary or nonstationary), and provides better results than other known differentiation methods, in the audio band up to 21 kHz.
Changes in nail position and antirotation blade angles on the risk of femoral head varus in PFNA fixed patients: a clinical review and comprehensive biomechanical research
Authors: Huang Chenyi , Xu Wenqiang , Ye Xiong , Hong Wanying , Xu Yue , Liu Zongchao , Li Jingchi 
Published: June 2024

Abstract
Background
Femoral head varus triggers poor clinical prognosis in intertrochanteric fracture patients with proximal femoral nail antirotation (PFNA) fixation. Studies present that changes in nail position and screw insertion angles will affect fixation stability, but the biomechanical significance of these factors on the risk of femoral head varus has yet to be identified in PFNA fixed patients.

Methods
Clinical data in PFNA fixed intertrochanteric fracture patients have been reviewed, the relative position of intermedullary nail has been judged in the instant postoperative lateral radiography. Regression analyses have been performed to identify the effect of this factor on femoral head varus. Corresponding biomechanical mechanism has been identified by numerical mechanical simulations.

Results
A clinical review revealed that ventral side nail insertion can trigger higher risk of femoral head varus, corresponding numerical mechanical simulations also recorded poor fixation stability in models with ventral side nail insertion, and changes in the trajectory of anti-rotation blade will not obviously affect this tendency.

Conclusions
Ventral side insertion of intramedullary nail can trigger higher risk of femoral head varus in PFNA fixed patients by deteriorating the instant postoperative biomechanical environment, and changes in blade trajectory cannot change this tendency biomechanically. Therefore, this nail position should be adjusted to optimize patients’ prognosis.
Strong evidence supports the use of estradiol therapy for the treatment of vaginal inflammation: a two-way Mendelian randomization study
Authors: Xu Xiaosheng , Liu Yan , Feng Weiwei , Shen Jian 
Published: June 2024

AbstractObjectiveNowadays, there has been limited Mendelian randomization (MR) research focusing on the causal relationship between estradiol and vaginitis. Therefore, this study conducted a two-way MR study to clarify the causal effect and related influencing factors between them.MethodsAll genetic datasets were obtained using publicly available summary statistics based on individuals of European ancestry from the IEU GWAS database. MR analysis was performed using MR-Egger, weighted median (WM) and inverse variance weighted (IVW) methods to assess the causal relationship between exposure and outcome and to validate the findings by comprehensively evaluating the effects of pleiotropic effects and outliers.ResultsMR analysis revealed no significant causal relationship between estradiol and vaginitis risk. There was a negative correlation between estradiol and age at menarche (IVW, OR: 0.9996, 95% CI: 0.9992–1.0000,P = 0.0295; WM, OR: 0.9995, 95% CI: 0.9993–0.9998,P = 0.0003), and there was a positive correlation between age at menarche and vaginitis (IVW, OR: 1.5108, 95% CI: 1.1474–2.0930,P = 0.0043; MR-Egger, OR: 2.5575, 95% CI: 1.7664–9.6580,P = 0.0013). Estradiol was negatively correlated with age at menopause (IVW, OR: 0.9872, 95% CI: 0.9786–0.9959,P = 0.0041). However, there was no causal relationship between age at menopause and vaginitis (P > 0.05). In addition, HPV E7 Type 16, HPV E7 Type 18, andLactobacillushad no direct causal effects on estradiol and vaginitis (P > 0.05). Sensitivity analyses revealed no heterogeneity and horizontal pleiotropy.ConclusionWhen estrogen levels drop, it will lead to a later age of menarche, and a later age of menarche may increase the risk of vaginitis, highlighting that the longer the female reproductive tract receives estrogen stimulation, the stronger the defense ability is formed, and the prevalence of vaginitis is reduced. In conclusion, this study indirectly supports an association between reduced level of estrogen or short time of estrogen stimulation and increased risk of vaginitis.
Repetition suppression between monetary loss and social pain
Authors: Zhang Yue , Tan Huixin , Luo Siyang 
Published: June 2024

AbstractThe relationship between monetary loss and pain has been a recent research focus. Prior studies found similarities in the network representation patterns of monetary loss and pain, particularly social pain. However, the neural level evidence was lacking. To address this, we conducted an ERP experiment to investigate whether there is a repetitive suppression effect of monetary loss on the neural activity of social pain, aiming to understand if they engage overlapping neuronal populations. The results revealed that FRN amplitudes showed repetitive suppression effects of monetary loss on the neural activity of social pain. Our study suggests that monetary loss and social pain share common neural bases, indicating that they might involve shared neural modules related to cognitive conflict and affective appraisal.
The impact of virtual reality on practical skills for students in science and engineering education: a meta-analysis
Authors: Yang Chuanwen , Zhang Jinying , Hu Yongbin , Yang Xianmin , Chen Meitan , Shan Mengyue , Li Li 
Published: June 2024

AbstractVirtual reality (VR) has emerged as a promising tool for enhancing practical skills of students in science and engineering education. However, the effectiveness of VR in this context remains unclear due to inconsistent findings across studies. This meta-analysis aimed to synthesize the existing literature and investigate the overall impact of VR on practical skills among science and engineering students. A comprehensive literature search was conducted, yielding 37 empirical studies published between 2000 and 2022 that met the inclusion criteria. The analysis included 72 effect sizes, and the random-effects model was employed to account for heterogeneity among studies. The results revealed a significant moderate positive effect of VR on practical skills (g = 0.477). Moderator analyses indicated that the disciplinary category significantly influenced the effect size, with medical students demonstrating the largest improvement in practical skills. Additionally, using the practice approach combining with traditional methods yielded the highest effect size among the instructional approaches. The study also considered potential reasons behind the observed results and acknowledged certain constraints. Additionally, it proposed avenues for further inquiry to advance the understanding of the subject matter.
Loss of protein tyrosine phosphatase receptor delta PTPRD increases the number of cortical neurons, impairs synaptic function and induces autistic-like behaviors in adult mice
Authors: Cortés Bastián I. , Meza Rodrigo C. , Ancatén-González Carlos , Ardiles Nicolás M. , Aránguiz María-Ignacia , Tomita Hideaki , Kaplan David R. , Cornejo Francisca , Nunez-Parra Alexia , Moya Pablo R. , Chávez Andrés E. , Cancino Gonzalo I. 
Published: June 2024

Abstract
Background
The brain cortex is responsible for many higher-level cognitive functions. Disruptions during cortical development have long-lasting consequences on brain function and are associated with the etiology of brain disorders. We previously found that the protein tyrosine phosphatase receptor delta Ptprd, which is genetically associated with several human neurodevelopmental disorders, is essential to cortical brain development. Loss of Ptprd expression induced an aberrant increase of excitatory neurons in embryonic and neonatal mice by hyper-activating the pro-neurogenic receptors TrkB and PDGFRβ in neural precursor cells. However, whether these alterations have long-lasting consequences in adulthood remains unknown.

Results
Here, we found that in Ptprd+/- or Ptprd-/- mice, the developmental increase of excitatory neurons persists through adulthood, affecting excitatory synaptic function in the medial prefrontal cortex. Likewise, heterozygosity or homozygosity for Ptprd also induced an increase of inhibitory cortical GABAergic neurons and impaired inhibitory synaptic transmission. Lastly, Ptprd+/- or Ptprd-/- mice displayed autistic-like behaviors and no learning and memory impairments or anxiety.

Conclusions
These results indicate that loss of Ptprd has long-lasting effects on cortical neuron number and synaptic function that may aberrantly impact ASD-like behaviors.
Clinical complete response after trastuzumab deruxtecan 6th-line treatment for postoperative gastric cancer recurrence: a case report
Authors: Yamada Erika , Iwasaki Kenichi , Barroga Edward , Sakurai Toru , Enomoto Masaya , Shimoda Yota , Mazaki Junichi , Kuwabara Hiroshi , Hoshino Akihiro , Hayashi Yutaka , Ishizaki Tetsuo , Nagakawa Yuichi 
Published: June 2024

Abstract
Background
Despite the recent developments in the treatment of advanced or recurrent gastric cancer, the median survival time remains shorter than 15 months. Herein, we report a case of postoperative gastric cancer recurrence in which a complete clinical response was achieved with trastuzumab deruxtecan as 6th-line treatment.

Case presentation
A 70-year-old man underwent abdominal contrast-enhanced computed tomography (CT) during follow-up after rectal cancer surgery. The CT revealed an enlarged perigastric lymph node. After further examination, the patient’s condition was diagnosed as gastric cancer cT2N1H0P0M0 cStage IIA. The patient underwent distal gastrectomy and D2 lymph node dissection. The resulting pathological diagnosis was pT1bN3aH0P0 pStageIIB, HER2 score 3+. Abdominal contrast-enhanced CT 19 months postoperatively revealed para-aortic lymph node recurrence, thus systemic chemotherapy courses were planned. The primary treatment was a combination of S-1, cisplatin, and trastuzumab administered in 11 courses. However, there was an enlargement of the para-aortic lymph node which was evaluated as progressive disease. Systematic chemotherapy with various regimens was continued until the 5th-line treatment. However, therapeutic benefits were not achieved and lung metastasis was observed. Trastuzumab deruxtecan (TDXD) was initiated as 6th-line treatment. Abdominal contrast-enhanced CT at 4 months after the start of treatment showed marked shrinkage of the enlarged para-aortic lymph node and disappearance of the lung metastasis in the right upper lung lobe, which was evaluated as partial response (PR). The para-aortic lymph node metastasis was evaluated as PR with only a slight accumulation of SUV-Max 2.66 with a shrinking trend by positron emission tomography-computed tomography (PET-CT) performed after 1 year. Tumor markers CEA, CA19-9, and CA125 also improved significantly. PET-CT after 1 year and 4 months showed no lymph node enlargement or accumulation, indicating a complete response (CR). All tumor markers also normalized. The patient has maintained clinical CR without additional treatment to date.

Conclusions
We report the apparent first case of postoperative gastric cancer recurrence successfully treated with TDXD, achieving clinical CR with TDXD as a 6th-line treatment.
Nintedanib combined with immunosuppressive agents improves forced vital capacity in connective tissue disease-associated PF-ILD: a single-center study
Authors: Ushio Yusuke , Wakiya Risa , Kameda Tomohiro , Nakashima Shusaku , Shimada Hiromi , Miyagi Taichi , Sugihara Koichi , Mino Rina , Mizusaki Mao , Chujo Kanako , Kagawa Ryoko , Yamaguchi Hayamasa , Kadowaki Norimitsu , Dobashi Hiroaki 
Published: June 2024

Abstract
Background
In 2020, Nintedanib (NTB), a tyrosine kinase inhibitor, was the first drug approved worldwide for treating progressive fibrosing interstitial lung disease (PF-ILD). This study evaluated the efficacy and safety of NTB in Japanese patients with CTD-associated PF-ILD in a real-world setting, as there are few reports on this topic. We also evaluated the efficacy and safety of combination therapy with NTB and immunosuppressive agents (IS).

Methods
CTD-associated PF-ILD patients receiving NTB at our institution were included in this retrospective study. To evaluate the efficacy and safety of NTB, we investigated changes in forced vital capacity (FVC) (%), diffusing capacity for carbon monoxide (DLCO) (%), monthly change in FVC (%/month), serum Krebs von den Lungen-6 (KL-6) levels (U/mL) before and after NTB treatment, and adverse events (AEs) during NTB treatment. Moreover, to evaluate the efficacy of the NTB + IS combination therapy, we divided the patients into two groups: one received only NTB (NTB group), and the other received both NTB and IS (NTB + IS group) following the diagnosis of CTD-associated PF-ILD. We analyzed the differences in the changes of these variables between the two groups.

Results
Twenty-six patients with CTD-associated PF-ILD were included. After NTB treatment, there were no significant deteriorations in FVC (%) and DLCO (%), while the monthly change in FVC (%/month) significantly increased (p < 0.001). The changes in FVC (%) and the monthly change in FVC (%/month) were significantly greater in the NTB + IS group than in the NTB group. Following NTB treatment, the mean serum KL-6 levels significantly decreased (p < 0.001). AEs associated with NTB in this study were similar to those in previous clinical trials, and there was no significant difference in the incidence of AEs between the two groups.

Conclusions
This study demonstrates that NTB is an effective medication for slowing the progression of CTD-associated PF-ILD in real-world settings. NTB + IS combination therapy for CTD-associated PF-ILD may be more effective than NTB alone in slowing the progression of CTD-associated PF-ILD.
Challenges associated with managing treatment complications in an older patient with cardiac amyloidosis
Authors: An Soo Yeon , Yang Yujin 
Published: June 2024

Abstract
Background
Amyloidosis, particularly wild-type transthyretin amyloidosis (ATTRwt), is an increasingly recognized cause of heart failure with preserved ejection fraction in the aging population. The complexity of managing ATTRwt in older patients underscores the necessity for individualized treatment approaches, yet clinical guidelines are lacking. This case report contributes to the understanding of ATTRwt management in the elderly, emphasizing the intricacies of medication tolerance and therapeutic decision-making.

Case presentation
An 83-year-old Korean man with a history of hypertension presented with dyspnea and peripheral edema. Investigations including electrocardiography, transthoracic echocardiography, cardiac magnetic resonance, and Technetium pyrophosphate scintigraphy led to a diagnosis of ATTRwt cardiac amyloidosis. Initial management with heart failure medications, including an angiotensin-converting enzyme inhibitor, diuretic, and mineralocorticoid receptor antagonist, was modified due to evolving clinical presentations, such as hypotension and onset of atrial fibrillation. Challenges included intolerance to beta-blockers and bleeding complications from direct oral anticoagulant therapy. The patient’s treatment journey highlighted the need for personalized management strategies in older ATTRwt patients.

Conclusions
This case illustrates the challenges in diagnosing and managing ATTRwt amyloidosis in the elderly, particularly the complexities in medication management due to the patient’s age, comorbid conditions, and side effects. It underscores the importance of a tailored approach in managing ATTRwt in older populations and highlights the need for ongoing research and development of treatment strategies tailored to this demographic.
Comparative Phenotyping of Mice Reveals Canonical and Noncanonical Physiological Functions of TRα and TRβ
Authors: Hönes Georg Sebastian , Geist Daniela , Wenzek Christina , Pfluger Paul Thomas , Müller Timo Dirk , Aguilar-Pimentel Juan Antonio , Amarie Oana Veronica , Becker Lore , Dragano Natalia , Garrett Lillian , Hölter Sabine Maria , Rathkolb Birgit , Rozman Jan , Spielmann Nadine , Treise Irina , Wolf Eckhard , Wurst Wolfgang , Fuchs Helmut , Gailus-Durner Valerie , Hrabe de Angelis Martin , Führer Dagmar , Moeller Lars Christian 
Published: June 2024

Abstract
Thyroid hormone (TH) effects are mediated through TH receptors (TRs), TRα1, TRβ1, and TRβ2. The TRs bind to the DNA and regulate expression of TH target genes (canonical signaling). In addition, they mediate activation of signaling pathways (noncanonical signaling). Whether noncanonical TR action contributes to the spectrum of TH effects is largely unknown. The aim of this study was to attribute physiological effects to the TR isoforms and their canonical and noncanonical signaling. We conducted multiparameter phenotyping in male and female TR knockout mice (TRαKO, TRβKO), mice with disrupted canonical signaling due to mutations in the TR DNA binding domain (TRαGS, TRβGS), and their wild-type littermates. Perturbations in senses, especially hearing (mainly TRβ with a lesser impact of TRα), visual acuity, retinal thickness (TRα and TRβ), and in muscle metabolism (TRα) highlighted the role of canonical TR action. Strikingly, selective abrogation of canonical TR action often had little phenotypic consequence, suggesting that noncanonical TR action sufficed to maintain the wild-type phenotype for specific effects. For instance, macrocytic anemia, reduced retinal vascularization, or increased anxiety-related behavior were only observed in TRαKO but not TRαGS mice. Noncanonical TRα action improved energy utilization and prevented hyperphagia observed in female TRαKO mice. In summary, by examining the phenotypes of TRα and TRβ knockout models alongside their DNA binding–deficient mutants and wild-type counterparts, we could establish that the noncanonical actions of TRα and TRβ play a crucial role in modulating sensory, behavioral, and metabolic functions and, thus, contribute to the spectrum of physiological TH effects.
Entering the Seemingly Unattainable Citadel of Laṅkā
Authors: Shen Hsueh-Man 
Published: June 2024

Abstract
Among extant sites of stone sutras in China, Mount Gang stands out because of the visuality it creates and the experience it affords. This paper explores how the carving and subsequent placement of an interpolated prologue of the Laṅkāvatāra Sutra across many rocks on the mountain conduce to a multi-sensorial, immersive experience for visitors to contemplate the sutra doctrine of Consciousness Only. It shows that tactics applied to the stone inscriptions induce an onward and upward journey over Mount Gang. Moreover, they conjure Laṅkā while simultaneously negating its existence, as the inscriptions and their environment remind visitors of Rāvaṇa's dreamlike experience of Laṅkā. This mental-physical experience afforded by the created environment makes visitors realize that all phenomena are but mental projections, which is the key doctrinal message of the sutra. Once they realize this, they hold the key to the seemingly unattainable Citadel of Laṅkā.