bluuebunny/crossref_metadata_2025_split huggingface dataset:
Will competition from Meteorus pulchricornis (Wesmael) (Hymenoptera: Braconidae) limit the success of the potential biocontrol agent Cotesia urabae Austin & Allen (Hymenoptera: Braconidae)?
Authors: Berndt Lisa A 
Published: November 2010

AbstractThe competitive ability of the generalist parasitoid Meteorus pulchricornis was compared with that of the proposed new biological control agent Cotesia urabae to determine the impact the former species might have on the ability of the agent to control its host Uraba lugens Walker (Lepidoptera: Nolidae) in New Zealand. Behavioural observations were made of females of each species exposed together to groups of U. lugens larvae. Meteorus pulchricornis did not successfully attack U. lugens in the presence of C. urabae, and the mortality of the host in the presence of M. pulchricornis alone did not differ from mortality when no parasitoids were present. The presence of M. pulchricornis in the same arena did not reduce the impact of C. urabae on U. lugens compared to controls. Field collections of U. lugens larvae found limited evidence of larval parasitism by M. pulchricornis. These results suggest that the resident parasitoid M. pulchricornis is unlikely to interfere with the success of the proposed biological control agent C. urabae, should it be introduced to New Zealand.
Anoxygenic photosynthesis and photooxidative stress: a particular challenge for Roseobacter
Authors: Berghoff Bork Ansgar , Glaeser Jens , Nuss Aaron Mischa , Zobawa Monica , Lottspeich Friedrich , Klug Gabriele 
Published: November 2010

SummaryRoseobacter clade aerobic anoxygenic phototrophic bacteria (AAnP) are abundant in photic zone environments of marine ecosystems. These bacteria form a photosynthetic apparatus at oxygen saturation, a situation expected to generate high levels of singlet oxygen (1O2) when light is present. Rhodobacter sphaeroides, an anaerobic anoxygenic phototroph, represses photosynthesis genes at high oxygen tension. Here we report that Roseobacter denitrificans showed higher sensitivity to 1O2 compared with Rhb. sphaeroides. While photosynthetic membranes of Rsb. denitrificans generated more 1O2 during light exposure, key regulator genes rpoE and rpoHII were more strongly induced in response to 1O2 stress compared with Rhb. sphaeroides. The regulon controlled by RpoE was different in Rsb. denitrificans and Rhb. sphaeroides. Patterns of synthesized soluble proteins strongly changed upon high light exposure in Rsb. denitrificans but not in Rhb. sphaeroides, and most changes were not further promoted by artificial 1O2 generation. The strong increase of small RNA RDs2461 levels by photooxidative stress implies a role for sRNAs in post‐transcriptional regulation of the response to 1O2 in AAnPs. Our data reveal similarities but also significant differences in the response of Rsb. denitrificans and Rhb. sphaeroides to 1O2, most likely a consequence of their different lifestyles.
Acidobacteria, Rubrobacteridae and Chloroflexi are abundant among very slow‐growing and mini‐colony‐forming soil bacteria
Authors: Davis Kathryn E. R. , Sangwan Parveen , Janssen Peter H. 
Published: November 2010

SummaryEasily visible colonies of bacteria continued to form on plates inoculated with soil and incubated for 24 weeks. Using two different media, 13% and 29% of easily visible colonies appeared after more than 12 weeks. In addition, 10% and 18% of all colonies had diameters of 25–200 µm (mini‐colonies), which could not be readily seen with the unaided eye. Members of soil bacterial groups that are only rarely cultured, such as members of the subclass Rubrobacteridae of the phylum Actinobacteria, members of subdivisions 1 and 2 of the phylum Acidobacteria and members of three subphyla of the phylum Chloroflexi, were more abundant among the easily visible colonies and mini‐colonies that developed after > 12 weeks of incubation. Our results indicate that there is a hidden culturable diversity of soil bacteria that may require laboratory study at colony sizes and incubation periods outside those commonly anticipated by most microbiologists. Working at these scales increases the likelihood of obtaining cultures from groups of soil bacteria that have generally eluded laboratory study by cultivation methods.
PRODUCTIVITY GROWTH AND THE PHILLIPS CURVE: A REASSESSMENT OF THE US EXPERIENCE
Authors: Karanassou Marika , Sala Hector 
Published: November 2010

ABSTRACTIn this paper, we analyse a new Phillips curve (NPC) model and demonstrate that (i) frictional growth, i.e., the interplay of wage staggering and money growth, generates a non‐vertical NPC in the long run and (ii) the Phillips curve (PC) shifts with productivity growth. On this basis we estimate a dynamic system of macro‐labour equations to evaluate the slope of the PC and explain the evolution of inflation and unemployment in the USA from 1970 to 2006. Because our empirical methodology relies heavily on impulse response functions, it represents a synthesis of the traditional structural modelling and (structural) vector autoregressions. We find that the PC is downward‐sloping with a slope of −3.58 in the long run. Furthermore, during the stagflating 1970s, the productivity slowdown contributed substantially to the increases in both unemployment and inflation, whereas the monetary expansion was quite ineffective and led mainly to higher inflation. Finally, the monetary expansion and productivity speedup of the roaring 1990s were both responsible for the significant lowering of the unemployment rate.
NUMERAIRE, SAVINGS AND THE INSTABILITY OF A COMPETITIVE EQUILIBRIUM
Authors: Parrinello Sergio 
Published: November 2010

ABSTRACTThis paper addresses the stability of a multimarket competitive equilibrium. The dependence of stability on the choice of the numeraire is clarified. The traditional tâtonnement pricing is revised in order to satisfy some basic features of economic behaviour. Well‐known conditions for local stability are proved to be insufficient if a market for credit is introduced alongside the markets of dated commodities. Stability depends not only on the slopes of the demand and supply curves, but also on equilibrium prices. This result emerges without the occurrence of capital perversities, such as reswitching and reverse capital deepening.
Exogenous ochronosis in ethnic Chinese Asians: a clinicopathological study, diagnosis and treatment
Authors: Tan S.K. 
Published: November 2010

AbstractBackground  Exogenous ochronosis is believed to be an uncommon complication of treatment with hydroquinone‐ containing skin‐lightning agents. It is widely believed that the condition is found almost exclusively in dark‐skinned individuals and uncommon in other skin‐types.Aims  To show that exogenous ochronosis may be present in ethnic Chinese Asians.Materials & Methods  Facial skin biopsies were obtained from suspicious lesions in ethnic Chinese patients presenting at a private dermatology clinic. Clinical photographs, ultraviolet (UV) photographs and digital dermatoscopic pictures were also obtained.Results  15 patients of ethnic Chinese origin had histologically‐confirmed exogenous ochronosis.Discussion  The difficulties in differentiating exogenous ochronosis from melasma are discussed and there is a likelihood of under‐reporting as the clinical presentation of the condition may be misleading.Conclusion  Exogenous ochronosis may exist amongst ethnic Chinese patients with fairer skin‐types, contrary to the commonly‐accepted perception that it is more prevalent in darker skin‐types.
Cutaneous angiosarcoma is a rare aggressive malignant vascular tumour of the skin
Authors: Wollina U. , Hansel G. , Schönlebe J. , Averbeck M. , Paasch U. , Uhl J. , Hindemann W. , Simon J.‐C. 
Published: November 2010

AbstractBackground  Cutaneous angiosarcoma (AS) is a rare aggressive malignant vascular tumour of the skin.Methods  We analysed the cases of cutaneous AS in two large dermatological departments of Saxony during the last 10 years.Results  A total of eight AS cases were identified, mostly with head and neck involvement. Because of age and late diagnosis, only a minor part was completely resectable. As a palliative therapy pegylated liposomal doxorubicin was used. The drug was well tolerated. Our cases and those published in the literature suggest a high rate of responses and a possible sensitisation to subsequent radiation therapy.Conclusions  Although complete surgical resection followed by wide‐field radiation therapy has been established as a therapeutic standard for AS, delay in diagnosis and older age with comorbidities warrant for a safe and effective adjuvant treatment. Pegylated liposomal doxorubicin combined with radiotherapy seems to be a useful and safe alternative.
Human papillomavirus typing of warts and response to cryotherapy
Authors: Tomson N. , Sterling J. , Ahmed I. , Hague J. , Berth‐Jones J. 
Published: November 2010

AbstractBackground  Cutaneous warts are common and caused by a number of different types of human papillomaviruses (HPVs).Objective  The aim of this study was to investigate the HPV types causing common warts and to determine any association between the HPV type and the duration of warts and response to cryotherapy.Methods  Eighty wart samples from 76 immunocompetent patients were taken from warts by paring prior to cryotherapy and analysed by in situ hybridization (ISH) with HPV probes specific to HPV 1, 2, 3, 4, 7, 10 and 57 and PCR analysis using degenerate cutaneous HPV primers with subsequent DNA sequencing. Each patient's details, including site, duration and response of the wart to cryotherapy were recorded. Cryotherapy was performed at 2 week intervals for a maximum of 12 weeks.Results  An HPV type was identified in 65 samples. The majority of warts (58 samples) were typed as HPV 2/27/57 by ISH and/or PCR. Three of the 18 samples that were HPV negative with ISH were HPV positive by PCR. Response to treatment did not correlate with HPV type, duration or location. In the 21 wart parings taken from patients aged 16 and under, response to treatment did not correlate with HPV type but warts of shorter duration were more likely to resolve with cryotherapy treatment than longer standing lesions.Conclusion  This study demonstrates that HPV type can be determined from wart parings. HPV‐2 related viruses are the prevalent HPV types causing common warts on the hands and feet in this population.
Excessive nickel release from earrings purchased from independent shops and street markets – a field study from Warsaw and London
Authors: Thyssen J.P. , Menné T. , Lidén C. , White I.R. , White J. , Spiewak R. , Johansen J.D. 
Published: November 2010

AbstractBackground  Nickel allergy is frequent and cause morbidity and increased health care costs.Objective  The aim of this study was to determine the proportion of inexpensive earrings randomly purchased from stores and street markets in two capitals that gave positive dimethylglyoxime (DMG) test reactions and to determine whether the degree of nickel release was related to shop category.Methods  Random inexpensive metallic earrings were purchased from stores and vendors in London and Warsaw. A qualitative investigation of nickel release by using the DMG test was performed.Results  DMG testing revealed that respectively 15.1% (n = 205) and 18.4% (n = 206) of earrings purchased in London and Warsaw released nickel as indicated by positive test outcomes. Stratification by store category showed that DMG test‐positive jewellery were mainly purchased from street markets and from stores that were not part of national or international chains.Conclusions  Despite the EU Nickel Directive having resulted in decreasing prevalence of nickel allergy, a large proportion of inexpensive earrings still release nickel in concentrations that may result in nickel allergy and dermatitis. Authorities should prioritize information campaigns and random inspections as a legislation that is not followed is of limited value.
Keloid histopathology after intralesional cryosurgery treatment
Authors: Har‐Shai Y. , Mettanes I. , Zilberstein Y. , Genin O. , Spector I. , Pines M. 
Published: November 2010

AbstractBackground  Keloid presents a great healthcare challenge. The patients suffer from aesthetic disfiguration and occasionally from pruritus, pain and discomfort. Although various treatments are recommended, a single, highly effective treatment represents a great clinical need.Objective  The cellular events and histopathology that follow intralesional cryosurgery were evaluated including cell proliferation, the number of cells expressing fibroblast markers, collagen synthesis and organization and mast cell infiltration.Methods  Biopsies were collected before and after intralesional cryoneedle procedure. Collagen structure was evaluated with confocal microscopy. Mast cells, blood vessels and cell proliferation were evaluated using immunohistochemistry.Results  Keloids contain abnormally thick collagen bundles, organized in swirls comprising closely bound fibrils. After intralesional cryosurgery, the collagen bundles lost their swirl structure, the thickness of the collagen layer decreased, and the bundles became more compact with less space between the fibres. A clear distinct transition zone separated the treated from the unaffected area. The frozen tissue was devoid of proliferating cells and mast cells whereas the number of blood vessels remained unaltered. Most of the fibroblasts expressed all tested myofibroblast markers although some exclusively expressed one and not the other. Few nuclei were observed in the affected area after treatment and very few of them expressed any fibroblast markers.Conclusions  Intralesional cryosurgery resulted in major changes in collagen structure and organization. The treatment reduced the number of proliferating cells, of myofibroblasts and of mast cells. These results may explain the reduction in no‐response rate and the amelioration of the clinical symptoms after intralesional cryosurgery treatment.
Juvenile, insulin‐dependent diabetes mellitus, type 1‐related dermatoses
Authors: Sehgal VN , Bhattacharya SN , Verma P 
Published: November 2010

AbstractJuvenile insulin‐dependent diabetes mellitus type 1 (IDDM) is a well‐recognized worldwide entity, the significance of which has increased because of its recent upsurging trends, warranting attention on variety of its clinical expressions, in particular, pertaining to skin, an aspect seldom taken cognizance of. Hence an endeavour to recap the related dermatoses, such as limited joint mobility syndrome including sclerodermoid (scleroderma–like) changes, xerosis, necrobiosis lipoidica diabeticorum, granuloma annulare, diabetic foot syndrome, has been made. Complexities relating to the recently explored issues of atopic dermatitis and drug hypersensitivity syndrome have also been covered adequately. In addition, the current concepts of the physiopathology of type 1 diabetes‐related dermatoses are briefly recapitulated for clarity.
Responses to ustekinumab in the anti‐TNF agent‐naïve vs. anti‐TNF agent‐exposed patients with psoriasis vulgaris
Authors: Clemmensen A. , Spon M. , Skov L. , Zachariae C. , Gniadecki R. 
Published: November 2010

AbstractBackground  Approximately 20–30% of patients with psoriasis treated with anti‐tumour necrosis factor α (TNFα) agents will discontinue treatment within 2 years due to loss of efficacy or side‐effects. Switching to another anti‐TNFα agent produces clinical responses inferior to previously untreated patients. Ustekinumab binds to the p40 subunit of interleukin (IL)‐12 and IL‐23 and provides a mechanism of action independent of TNFα.Objective  To investigate the efficacy of ustekinumab in a clinical practice setting and to compare treatment responses to ustekinumab in patients previously treated with TNFα inhibitors and anti‐TNFα‐naïve patients.Methods  Patients receiving either ustekinumab (n = 71) or the subcutaneous TNFα inhibitors adalimumab or etanercept (n = 108) were identified through the registry of psoriasis patients in our Institutions. Efficacy effect outcome was a 75% improvement in the psoriasis area severity index (PASI75). Kaplan–Meier statistics evaluated the adherence to the treatments expressed as drug survival rate.Results  PASI75 was achieved in 80% of the ustekinumab‐treated patients after a median time of 112 days. There was no difference in efficacy in anti‐TNFα‐naïve patients compared with anti‐TNFα unresponsive patients. Patients treated with ustekinumab showed a superior adherence to treatment in comparison with adalimumab and etanercept.Limitations  Patients were non‐randomly assigned to treatment, which potentially may lead to biases. Observation time was short (1 year).Conclusion  In clinical practice, the short‐term efficacy and patient adherence to ustekinumab are excellent and comparable to the data obtained in clinical trials. Lack of response to previous anti‐TNF treatment does not impair clinical response to ustekinumab.
Pregnancy outcomes in women with moderate‐to‐severe psoriasis
Authors: Cohen‐Barak E. , Nachum Z. , Rozenman D. , Ziv M. 
Published: November 2010

AbstractBackground  The association between psoriasis and pregnancy outcomes has not been adequately examined, although psoriasis onset is common in the reproductive period.Objective  To evaluate the association between moderate‐to‐severe psoriasis and pregnancy complications.Methods  A retrospective, matched cohort study of 68 deliveries in 35 women with moderate‐to‐severe psoriasis compared to 237 deliveries in 236 women without psoriasis randomly selected after matching for age, parity and gestational age.Results  The psoriasis patients had higher mean of past spontaneous (0.42 ± 0.58 vs. 0.26 ± 0.63, P = 0.002) and induced (0.32 ± 0.60 vs. 0.06 ± 0.25, P = 0.001) abortions than controls. They had a higher percentage of pregnancy‐induced hypertensive diseases (7.4% vs. 2.1%, P < 0.05) and premature rupture of membranes (16% vs. 5.5%, P < 0.008). Newborns to women with psoriasis had higher birth weight (3375 ± 543 g vs. 3247 ± 460 g, P = 0.03), increased percentage of large‐for‐gestational age (24% vs. 12%, P = 0.02), and macrosomia (13% vs. 4.2%P = 0.02). In multivariate analysis, moderate‐to‐severe psoriasis was an independent risk factor for previous spontaneous abortions, induced abortions, premature rupture of membranes (PROM), and newborn macrosomia.Conclusion  Moderate‐to‐severe psoriasis is associated with spontaneous and induced abortions, pregnancy‐induced hypertensive diseases, premature rupture of membranes, large‐for‐gestational age newborns, and macrosomia.
Lacking CD56 expression in a relapsing cutaneous blastic plasmacytoid dendritic cell neoplasm after allogeneic bone marrow transplantation: FISH analysis revealed loss of 11q
Authors: Mitteldorf C. , Bertsch H.P. , Baumgart M. , Haase D. , Wulf G. , Schön M.P. , Rosenwald A. , Neumann C. , Kaune K.M. 
Published: November 2010

AbstractBackground  Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare entity characterized by a CD4+/CD56+/CD123+ immunophenotype and a fatal clinical course. The average survival of 12–14 months may be prolonged by allogeneic bone marrow transplantation (BMT).Objectives  We report about a male patient who suffered from BPDCN with a typical histology and co‐expression of CD4/CD123 and a CD56 expression by 80% of the tumour cells. The cutaneous tumour relapse after chemotherapy and allogeneic BMT was completely negative for CD56.Methods  We performed interphase fluorescence in situ hybridization (FISH) analysis of tumour tissue, asserved before and after BMT, using specific probes for chromosome 11, which encompass the CD56 gene region.Results  The tumour cells revealed a partial loss of 11q as well as a monosomy of chromosome 11.Conclusion  This case demonstrates for the first time that loss of CD56 expression can also occur as a secondary event after chemotherapy and BMT. In our case, DNA loss of 11q23 could be responsible for the negativity of 20% of tumour cells as observed before chemotherapy. However, the complete loss of CD56 expression in the relapsed tumour cannot be explained by the loss of 11q23 alone. Additional factors such as chemotherapy‐induced mutations might also have contributed.
Hormonal Contraception and HIV‐1 Transmission
Authors: Blish Catherine A. , Baeten Jared M. 
Published: November 2010

Citation Blish CA, Baeten JM. Hormonal contraception and HIV‐1 transmission. Am J Reprod Immunol 2011; 65: 302–307Safe and effective contraceptive choices are essential for women with HIV‐1 infection and at risk for HIV‐1 infection. Epidemiological and laboratory‐based studies suggest that hormonal contraception may influence HIV‐1 transmission. Several large studies in high‐risk populations indicate that hormonal contraceptive use may modestly increase the risk of HIV‐1 acquisition. In addition, HIV‐1‐infected users of hormonal contraceptives may be more infectious to their uninfected partners, although no studies have directly measured HIV‐1 transmission risk from women to men. However, several studies failed to demonstrate a link between contraceptive use and HIV‐1 acquisition or transmission, and interpretation of many studies limited by methodological considerations, such as infrequent measurements of contraceptive exposure and HIV‐1 status. As a result, many questions remain, and high‐quality studies remain needed. It is clear that hormonal contraceptives are not protective against HIV‐1 infection and that dual protection with condoms should be the goal for women using hormonal contraception.
Blaschkitis in children – a new entity?
Authors: Denk Katharina , Flux Katharina 
Published: November 2010

SummaryBlaschkitis is an acquired, rare dermatitis that follows the lines of Blaschko. Many consider blaschkitis as a variant of lichen striatus, although authors felt that it is a separate entity. A 2½‐year‐old girl presented with multiple grouped papules along the lines of Blaschko on her trunk. The main differences to lichen striatus are illustrated. Our case supports the hypothesis that blaschkitis is an entity of its own.
BerEP4‐negative basal cell carcinoma on the palm: case report and review of the literature
Authors: Mleczko Anna , Franke Ingolf , Pokrywka Anna , Gollnick Harald , Leverkus Martin 
Published: November 2010

SummaryOnly 10 cases of patients with isolated basal cell carcinoma (BCC) of the palms and soles have been published. We describe a patient with an isolated basal cell carcinoma of the palm. Our patient denied injury and exposure to noxious agents; he did not have basal cell nevus syndrome. The tumor was negative for EpCAM as determined by BerEP4 immunohistochemistry, although EpCAM expression usually is seen in BCC in more conventional locations. Because the tumor cells were connected to secretory eccrine glands, we speculate that BCC of the palm originates from common progenitor cells of eccrine glands or epidermal stem cells. We review the literature on these rare BCC in atypical anatomical regions, and discuss the cellular origin of BCC in such locations.