bluuebunny/crossref_metadata_2025_split huggingface dataset:
To explore the prognostic characteristics of colon cancer based on tertiary lymphoid structure-related genes and reveal the characteristics of tumor microenvironment and drug prediction
Authors: Wang Zhanmei , Niu Dongguang 
Published: June 2024

AbstractIn order to construct a prognostic evaluation model of TLS features in COAD and better realize personalized precision medicine in COAD. Colon adenocarcinoma (COAD) is a common malignant tumor of the digestive system. At present, there is no effective prognostic marker to predict the prognosis of patients. Tertiary lymphoid structure (TLS) affects cancer progression by regulating immune microenvironment. Mining COAD biomarkers based on TLS-related genes helps to improve the prognosis of patients. In order to construct a prognostic evaluation model of TLS features in COAD and better realize personalized precision medicine in COAD. The mRNA expression data and clinical information of COAD and adjacent tissues were downloaded from the Cancer Genome Atlas database. The differentially expressed TLS-related genes of COAD relative to adjacent tissues were obtained by differential analysis. TLS gene co-expression analysis was used to mine genes highly related to TLS, and the intersection of the two was used to obtain candidate genes. Univariate, LASSO, and multivariate Cox regression analysis were performed on candidate genes to screen prognostic markers to construct a risk assessment model. The differences of immune characteristics were evaluated by ESTIMATE, ssGSEA and CIBERSORT in high and low risk groups of prognostic model. The difference of genomic mutation between groups was evaluated by tumor mutation burden score. Screening small molecule drugs through the GDSC library. Finally, a nomogram was drawn to evaluate the clinical value of the prognostic model. Seven TLS-related genes ADAM8, SLC6A1, PAXX, RIMKLB, PTH1R, CD1B, and MMP10 were screened to construct a prognostic model. Survival analysis showed that patients in the high-risk group had significantly lower overall survival rates. Immune microenvironment analysis showed that patients in the high-risk group had higher immune indicators, indicating higher immunity. The genomic mutation patterns of the high-risk and low-risk groups were significantly different, especially the KRAS mutation frequency was significantly higher in the high-risk group. Drug sensitivity analysis showed that the low-risk group was more sensitive to Erlotinib, Savolitinib and VE _ 822, which may be used as a potential drug for COAD treatment. Finally, the nomogram constructed by pathological features combined with RiskScore can accurately evaluate the prognosis of COAD patients. This study constructed and verified a TLS model that can predict COAD. More importantly, it provides a reference standard for guiding the prognosis and immunotherapy of COAD patients.
LHHW/RSM reaction rate modeling for Co-Mn/SiO2 nanocatalyst in Fishcher-Tropsch synthesis
Authors: Azizi Hamid Reza , Mansouri Mohsen , Farshchi Tabrizi Farshad , Mansouri Ghobad , Setareshenas Naimeh 
Published: June 2024

AbstractThis study aims to assess the kinetics of Fischer–Tropsch (FT) reaction over the cobalt-manganese nanoparticles supported by silica oxide. Nanoparticles were synthesized by the thermal decomposition method using "[Co(NH3)4CO3]MnO4" complex and characterized by XRD, TEM, and BET techniques. The kinetics of the process were evaluated using a combination of Langmuir–Hinshelwood-Hougen-Watson (LHHW) and response surface methodology. Correlation factors of 0.9902 and 0.962 were obtained for the response surface method (RSM) and LHHW, respectively. The two methods were in good agreement, and the results showed that the rate-determining step was the reaction of the adsorbed methylene with the adsorbed hydrogen atom, and only carbon monoxide molecules were the most active species on the catalyst surface. A temperature of 502.53 K and a CO partial pressure of 2.76 bar are proposed as the optimal conditions by RSM analysis. The activation energy of CO consumption reaction was estimated to be 61.06 kJ/mol.
Optimization design of battery bracket for new energy vehicles based on 3D printing technology
Authors: Zhang Guoqing , Li Xueyan , Li Junxin , Zhou Xiaoyu , Zhou Yongsheng 
Published: June 2024

AbstractNowadays, what captures consumers' primary attention is how to purchase electric vehicles with long range and desirable price. Lightweight construction stands as one of the most effective approaches for prolonging range and lowering costs. As a consequence, it is particularly imperative to undertake lightweight design optimization for the battery bracket of new energy vehicles by applying 3D printing technology. To actualize this goal, Rhino software was initially employed for 3D modeling to design the battery bracket system for a pure electric vehicle in China. Subsequently, topology optimization design of the battery bracket was carried out by adopting Altair Inspire software. Last but not least, manufacturing and assembly inspection were completed using a 3D printer. The results show that the maximum displacement of the battery lower tray bracket after topology optimization is 3.20 mm, which is slightly higher than before, but still relatively small. The maximum Mises equivalent stress rose to 240.7 MPa post-optimization, but brought about a uniform stress distribution at the bottom of the bracket. In comparison, the minimum factor of safety met design requirements at 1. The mass was lessened to 0.348 kg, representing a 49.2% decrease in comparison with pre-optimization levels. The 3D-printed bracket was fabricated by employing a 3D printer, thereby achieving the aforementioned mass abatement. The battery pack parts exhibited a bright surface with low roughness and no discernible warping or deformation defects. As revealed by the assembly results, the components of the battery pack bracket are tightly coordinated with each other, with no evident assembly conflicts, revealing that the dimensional accuracy and fit of the completed parts meet production requirements. These findings lay solid groundwork for the mass production of high-performance battery pack brackets.
Analytical and experimental analysis of concrete temperature and energy considering open-air environmental variations
Authors: Yang Wen-Jian , Li Peng , Zhuo Li , Pang Ming-Liang , Xie Hong-Qiang , Xiao Ming-Li 
Published: June 2024

AbstractLongwave radiation is an important open-air environmental factor that can significantly affect the temperature of concrete, but it has often been ignored in the temperature analysis of open-air concrete structures. In this article, an improved analytical model of concrete temperature was proposed by considering solar radiation, thermal convection, thermal conduction and especially longwave radiation. Temperature monitoring of an open-air concrete block was carried out to verify the proposed model and analyze the heat energy characteristics of open-air concrete. As demonstrated by the open-air experiment, under the influence of longwave radiation, the temperature at the top of the concrete block could decrease rapidly at night and even become lower than the minimum temperature at its bottom. Compared with the analytical model that ignores longwave radiation, the improved model that includes it better matches the measured temperature. According to the energy analysis, although solar radiation controls the transient variation in heat energy, the heat exchange caused by longwave radiation were more than that caused by convection on sunlit surfaces, which indicates the importance of considering longwave radiation.
Historical sensible-heat-flux variations key to predicting future hydrologic sensitivity
Authors: Norris Jesse , Thackeray Chad W. , Hall Alex , Madakumbura Gavin D. 
Published: June 2024

AbstractUnder anthropogenic climate change (CC), the global hydrological cycle intensifies at a rate known as hydrologic sensitivity (HS). Global climate models (GCMs) exhibit substantial uncertainty in HS. Past work suggests that another form of HS, derived from internal climate variability (IV), is useful for constraining this uncertainty. However, these two forms of HS are weakly related. Here we show that decomposing HS under both CC and IV, based on the global energy budget, provides insight into the likely range of future HS. We find that sensible heat exchange between the atmosphere and ocean is not accounted for in the atmospheric energy budget under IV, masking the connection between HS under IV and CC. Removing this term, a closer relationship emerges. We use observations in conjunction with this relationship to suggest an upward shift in the likely range of future HS (66% confidence interval: 2.00–2.36 W m−2 K−1).
Dual nature of magnetism driven by momentum dependent f-d Kondo hybridization
Authors: Kang Byungkyun , Lee Yongbin , Ke Liqin , Kim Hyunsoo , Kim Myoung-Hwan , Park Chul Hong 
Published: June 2024

AbstractThe intricate nature of magnetism in uranium-based Kondo lattices is a consequence of correlations between U-5f and conduction electrons. Previously, the source of magnetism has been ascribed to either Mott physics or Ruderman-Kittel-Kasuya-Yosida interaction, both of which are not fully applicable to uranium-based Kondo lattices. Using linearized quasiparticle self-consistent GW plus dynamical mean-field theory, we demonstrate a crossover from incoherent to coherent f-d Kondo cloud in the paramagnetic phase of UTe2, USbTe and USbSe. As the transition occurs, we observe an augmented f-d coherence and Pauli-like magnetic susceptibility, with a substantial frozen magnetic moment of U-5f persisting. We show that momentum dependent f-d hybridization is responsible for the magnetic moments arising from the renormalized f electrons’ van Hove singularity. Our findings provide a perspective to explain the dual nature of magnetism and the long-range magnetic ordering induced by pressure in UTe2.
Association of western US compound hydrometeorological extremes with Madden-Julian oscillation and ENSO interaction
Authors: Wang Jiabao , DeFlorio Michael J. , Gershunov Alexander , Guirguis Kristen , Delle Monache Luca , Ralph F. Martin 
Published: June 2024

AbstractExtreme weather and climate events can have substantial impacts on society and the environment. Compound extremes (two or more extreme events occurring simultaneously or successively) may exert even larger impacts than individual events. Here we examine physical drivers behind variability in hydrometeorological (precipitation and temperature) compound extremes on subseasonal-to-seasonal timescales. Observational evidence presented here through composite analysis indicates that compound extreme frequency is linked to the Madden-Julian oscillation, a unique type of organized tropical convection varying primarily on subseasonal-to-seasonal timescales. The linkage between Madden-Julian oscillation and compound extremes is largely dependent on ENSO phases, which can be seen through different magnitudes or changes in sign of the canonical relationship conditioned on ENSO states. Similarly, the Madden-Julian oscillation can interrupt the canonical ENSO-compound extreme relationship. Our results suggest a potential route to improve subseasonal-to-seasonal prediction of western US compound extremes by considering the combined effect of both Madden-Julian oscillation and ENSO.
Dexamethasone–tamoxifen combination exerts synergistic therapeutic effects in tamoxifen-resistance breast cancer cells
Authors: Gaballah Aliaa I. , Elsherbiny Aliaa A. , Sharaky Marwa , Hamed Najat O. , Raslan Nahed A. , Almilaibary Abdullah , Fayyad Reda Mohamed Abdrabbou , Ousman Mona S. , Hamdan Ahmed M.E. , Fahim Sally A. 
Published: June 2024

Abstract
Tamoxifen (TAM) is a key player in estrogen receptor-positive (ER+) breast cancer (BC); however, ∼30% of patients experience relapse and a lower survival rate due to TAM resistance. TAM resistance was related to the over expression of SOX-2 gene, which is regulated by the E2F3 transcription factor in the Wnt signaling pathway. It was suggested that SOX-2 overexpression was suppressed by dexamethasone (DEX), a glucocorticoid commonly prescribed to BC patients. The aim of the present study is to explore the effect of combining DEX and TAM on the inhibition of TAM-resistant LCC-2 cells (TAMR-1) through modulating the E2F3/SOX-2-mediated Wnt signaling pathway. The effect of the combination therapy on MCF-7 and TAMR-1 cell viability was assessed. Drug interactions were analyzed using CompuSyn and SynergyFinder softwares. Cell cycle distribution, apoptotic protein expression, gene expression levels of SOX-2 and E2F3, and cell migration were also assessed. Combining DEX with TAM led to synergistic inhibition of TAMR-1 cell proliferation and migration, induced apoptosis, reduced SOX-2 and E2F3 expression and was also associated with S and G2-M phase arrest. Therefore, combining DEX with TAM may present an effective therapeutic option to overcome TAM resistance, by targeting the E2F3/SOX-2/Wnt signaling pathway, in addition to its anti-inflammatory effect.
Introduction of ICD-11 in Germany: Seizing opportunities
together
Authors: Broich Karl , Callhoff Johanna , Kaskel Peter , Kowalski Christoph , Malzahn Jürgen , Mundlos Christine , Schöbel Christoph 
Published: June 2024

AbstractWith the new ICD-11 developed by the WHO and translated into German for use in
Germany by the Federal Institute for Drugs and Medical Devices, the German
healthcare system is facing a change that is more than a simple change of a
medical coding system. The ICD-11 modernises the coding system, for example, by
including new, separate health conditions such as sleep-wake disorders and
conditions related to sexual health, thus making the corresponding diseases more
visible. The ICD-11 is more precise than the ICD-10: it allows cross-referencing
between diagnoses, symptoms, functionality and locations and partially abandons
the strict hierarchy of the ICD-10. In addition, a greater number of rare
diseases are represented with their own specific code than was previously
possible with ICD-10. Finally, the ICD-11 is also significantly more “modern”
than the ICD-10 (which dates back to pre-digital times) in that it enables new,
digitally-supported processes, such as keywords flexibility and sustainability
when updating the system as well as actual coding at the point of care. The
switch to ICD-11 can be a great opportunity for the German healthcare system
that should not be missed. It will benefit health service research, which at
best will be able to work with much more detailed and correct data sets. But
medical care will also benefit because the ICD-11 reflects current medical
knowledge. In addition, certain illnesses will be removed from the psychiatric
category, meaning that those affected will no longer be stigmatised by their
classification in the ICD. The improved coding of diagnoses will ultimately also
support guideline-based treatments. However, the changeover is only the first
step. The challenges – also for health service research – include in particular
the latency of introduction and uniform use as well as the necessary change in
coding habits. For ICD-11 to be a success in Germany, authorities, the medical
profession, payers and patients must work together on strategies to ensure not
only a rapid but also a comprehensive implementation that maximises the
potential of ICD-11.
Rh(III)-Catalyzed, Redox-Neutral, C–H Multifluoroalkenylation of Benzamides
Authors: Chen Wen-Hua , Xu Jun , Wu Jia-Qiang , Lin Wei , Qu Yifei , Zhu Huixuan , Xie Mei , Hu Jinhui , Xiong Zhuang 
Published: June 2024

AbstractFluorinated molecules are widely used in pharmaceutical and agrochemical industries. Multifluoroalkyl-containing compounds have attracted increasing attention for their unique ability to alter the activity of drugs and bioactive molecules. Herein, we report an efficient Rh(III)-catalyzed, redox-neutral, C–H multifluoroalkenylation of benzamides with multifluoroalkenes, which provides a versatile protocol for accessing a wide range of multifluoroalkenylated arenes.
Directing-Group-Assisted Transition-Metal-Catalyzed Selective BH Functionalization of o-Carboranes
Authors: Xie Zuowei , Zhang Jie 
Published: June 2024

AbstractCarboranes are a type of molecular clusters consisting of carbon, hydrogen, and boron atoms. They possess unique characteristics, such as three-dimensional aromaticity, icosahedral geometry, and robustness. Functionalized carboranes have been utilized in various fields, including medicine, materials, and organometallic/coordination chemistry. In this context, selective functionalization of o-carboranes has received tremendous attention, specifically in the regio- and enantioselective modification of the ten chemically similar BH vertices within the carborane cage. In recent years, significant progress has been made in catalytic vertex-specific BH functionalization, as well as achieving enantioselective functionalization of the cage BH. This review provides an overview of the recent advancements in this research field.1	Introduction2	Carboxy-Assisted BH Functionalization2.1	Formation of B–C Bonds2.2	Formation of B–N Bonds2.3	Formation of B–O Bonds2.4	Formation of B–X Bonds2.5	Consecutive Formation of B–C and B–Y (Y = N, O) Bonds3	N-Based Directing-Group-Assisted B–H Functionalization3.1	Acylamino as a Directing Group3.2	Amide as a Directing Group3.3	Pyridyl as a Directing Group3.4	Imine as a Directing Group4	Phosphinyl-Assisted Cage B–H Functionalization5	Bidentate-Directing-Group-Assisted B–H Functionalization6	Other Directing-Group-Assisted B–H Functionalization7	Conclusions
Effects of COVID-19 Pandemic in Patients with a Previous Phrenic Nerve Transfer for a Traumatic Brachial Plexus Palsy
Authors: Socolovsky Mariano , Lu Johnny Chuieng-Yi , Zarra Francisco , Wei Chen Kuan , Chang Tommy Nai-Jen , Chuang David Chwei-Chin 
Published: June 2024

Abstract
Background With the advent of the coronavirus disease 2019 (COVID-19) pandemic, some doubts have been raised regarding the potential respiratory problems that patients who previously underwent a phrenic nerve transfer could have.
Objectives To analyze the effects of the coronavirus infection on two populations, one from Argentina and another from Taiwan. Specific objectives were: (1) to identify the rate of COVID in patients with a history of phrenic nerve transfer for treatment of palsy; (2) to identify the overall symptom profile; (3) to compare Argentinian versus Taiwanese populations; and (4) to determine if any phrenic nerve transfer patients are at particular risk of more severe COVID.
Methods A telephonic survey that included data regarding the number of episodes of acute COVID-19 infection, the symptoms it caused, the presence or absence of potential or life-threatening complications, and the status of COVID-19 vaccination were studied. Intergroup comparisons were conducted using the nonparametric Mann–Whitney U test, with categorical variables conducted using either the Pearson χ2 analysis or the Fisher's exact test, as appropriate.
Results A total of 77 patients completed the survey, 40 from Taiwan and 37 from Argentina. Fifty-five (71.4%) developed a diagnosis of COVID. However, among these, only four had any level of dyspnea reported (4/55 = 7.3%), all mild. There were also no admissions to hospital or an intensive care unit, no intubations, and no deaths. All 55 patients isolated themselves at home.
Conclusions It can be concluded that an acute COVID-19 infection was very well tolerated in our patients. (Level of evidence 3b, case reports).
Cisto de Baker gigante com extensão ao gastrocnêmio: Relato de caso
Authors: Siddiqui Adeel Ahmed , Khan Muhammad Waqas , Ali Taimoor , Ahmed Sajjad , Solangi Shahzaeb , Qamar Javeria 
Published: June 2024

ResumoO cisto de Baker é um aumento anormal da bursa gastrocnêmio-semimembranosa atrás da articulação do joelho devido ao efluxo de fluido articular.Relatamos um caso raro de cisto de Baker gigante em uma paciente com artrite reumatoide. A ressonância magnética mostrou um cisto complexo e multiloculado que media 11,8 cm x 4,6 cm x 3,3 cm, com origem na articulação do joelho esquerdo. Foi realizada excisão cirúrgica aberta da lesão. Não houve recidiva durante o acompanhamento de um ano no Departamento de Reumatologia e Ortopedia.Há uma tendência natural de extensão intermuscular, de modo que os relatos de extensões intramusculares são raros na literatura. Pelo que sabemos, nenhum cisto de Baker desse tamanho foi operado em pacientes com artrite reumatoide.
Prethrombin-1 as a Drug Substance Promoting Hemostasis with Reduced Risk of Thrombosis
Authors: Graus Johann Georg , Prückler Michael , Bergmeister Helga , Mader Christoph , Trefilov Alexandru , Gölles Richard , Kunschak Marianne , Schramm Wolfgang 
Published: June 2024

Introduction Prethrombin-1 is a Gla-domain lacking enzymatically inactive split product that results from the cleavage of fragment 1 from prothrombin by thrombin in a feedback reaction.
Methods A prethrombin-1 preparation derived from human plasma was tested for its hemostatic and thrombogenic properties. Animal models of nail clipping (for rabbits) and tail clipping (for mice) were developed to measure blood loss in FVIII-inhibitor or rivaroxaban anticoagulated rabbits and mice, respectively. A modified Wessler test was used in rabbits to assess the thrombogenic potential by Wessler score and clot weight. Studies were performed in groups of three to six for prethrombin-1 dose escalation and comparison with prothrombin, Beriplex®, FEIBA®, and saline as a control. Data were analyzed using t-statistics or the Mann Whitney U test as applicable.
Results Prethrombin-1 has excellent hemostatic properties in anticoagulated mouse and rabbit bleeding models. Wessler tests suggest that in contrast to activated and nonactivated prothrombin complexes, prethrombin-1 has negligible thrombogenic potential.
Conclusion The thrombin zymogen prethrombin-1 promotes hemostasis with reduced risk of thrombosis. Prethrombin-1 may have potential to become a life-saving treatment for patients who bleed or are at risk of bleeding.
A continuous-wave and pulsed X-band electron spin resonance spectrometer operating in ultra-high vacuum for the study of low dimensional spin ensembles
Authors: Cho Franklin H. , Park Juyoung , Oh Soyoung , Yu Jisoo , Jeong Yejin , Colazzo Luciano , Spree Lukas , Hommel Caroline , Ardavan Arzhang , Boero Giovanni , Donati Fabio 
Published: June 2024

We report the development of a continuous-wave and pulsed X-band electron spin resonance (ESR) spectrometer for the study of spins on ordered surfaces down to cryogenic temperatures. The spectrometer operates in ultra-high vacuum and utilizes a half-wavelength microstrip line resonator realized using epitaxially grown copper films on single crystal Al2O3 substrates. The one-dimensional microstrip line resonator exhibits a quality factor of more than 200 at room temperature, close to the upper limit determined by radiation losses. The surface characterizations of the copper strip of the resonator by atomic force microscopy, low-energy electron diffraction, and scanning tunneling microscopy show that the surface is atomically clean, flat, and single crystalline. Measuring the ESR spectrum at 15 K from a few nm thick molecular film of YPc2, we find a continuous-wave ESR sensitivity of 2.6 × 1011 spins/G · Hz1/2, indicating that a signal-to-noise ratio of 3.9 G · Hz1/2 is expected from a monolayer of YPc2 molecules. Advanced pulsed ESR experimental capabilities, including dynamical decoupling and electron-nuclear double resonance, are demonstrated using free radicals diluted in a glassy matrix.