bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and feasibility analysis of rapid daratumumab infusion in Chinese patients with multiple myeloma
Authors: Yin Xi‐xi , Hu Yueyun , Yang Yusi , Zhang Xinglan , Liu Li , Cao Xi , Chen Jianwen , Xia Zhongjun , Wang Ye 
Published: June 2024

AbstractBackgroundWith the increasing use of daratumumab (DARA)‐containing regimens for multiple myeloma (MM) patients in China, the standard infusion time of DARA is long, with the potential for infusion‐related reactions (IRRs) and increased hospitalization and use of resources. Shortening the duration of DARA infusion helps to optimize the hospital stay and enhance the patient treatment experience. The current, commonly used 90‐min rapid DARA infusion regimen may not be applicable to Chinese MM patients, and therefore, we explored a new 110‐min rapid DARA infusion regimen aimed at reducing the treatment burden on patients to guarantee therapeutic safety.MethodsMM inpatients treated with the DARA regimen were divided into two groups according to the number of times the DARA regimen was used: a standard infusion regimen for patients treated with the first two doses of DARA and a 110‐min rapid infusion regimen for patients treated with more than two doses of DARA. Anti‐allergy medications were routinely administered prior to the start of DARA infusion, patient consent, and authorization was obtained for all treatments, and statistical evaluation of the results was conducted via descriptive analyses, one‐way ANOVA and chi‐square tests.ResultsA total of 129 patients were included in this study: 68 in the standard infusion group, with 121 DARA infusions, and 129 in the rapid infusion group (patients who participated in the standard infusion subsequently participated in the rapid infusion), with 738 DARA infusions. The incidence of IRRs was 27.27% (36/121) in the standard infusion group and 1.35% (10/738) in the rapid infusion group, which were significantly different (p < 0.001). The incidence of IRRs after rapid infusion in other studies was <6%. The incidence of grade 1 IRRs in the rapid infusion group was 0.81% (6/738), the incidence of grade 2 IRRs was 0.54% (4/738), and there were no IRRs above grade 3; age, sex, and underlying disease had no effect on the choice of infusion method (p > 0.05). The mean infusion time after the occurrence of IRRs was also shorter in the rapid infusion group than in the standard infusion group (F = 24.781, p < 0.001).ConclusionThe 110‐min rapid infusion DARA regimen is feasible and safe for use in Chinese MM patients.
The clinical, molecular, and therapeutic implications of time from primary diagnosis to brain metastasis in lung and breast cancer patients
Authors: Ge Haitao , Zhu Kaibin , Sun Qian , Wang Huan , Liu Hui , Ge Jinyi , Liu Chunyang , Liang Peng , Lv Zhonghua , Bao Hongbo 
Published: June 2024

AbstractPurposeLung cancer (LC) and breast cancer (BC) are the most common causes of brain metastases (BMs). Time from primary diagnosis to BM (TPDBM) refers to the time interval between initial LC or BC diagnosis and development of BM. This research aims to identify clinical, molecular, and therapeutic risk factors associated with shorter TPDBM.MethodsWe retrospectively reviewed all diagnosed LC and BC patients with BM at Harbin Medical University Cancer Hospital from 2016 to 2020. A total of 570 patients with LC brain metastasis (LCBM) and 173 patients with breast cancer brain metastasis (BCBM) patients who met the inclusion criteria were enrolled for further analysis. BM free survival time curves were generated using Kaplan–Meier analyses. Univariate and multivariate Cox regression analyses were applied to identify risk factors associated with earlier development of BM in LC and BC, respectively.ResultsThe median TPDBM was 5.3 months in LC and 44.4 months in BC. In multivariate analysis, clinical stage IV and M1 stage were independent risk factors for early development of LCBM. LC patients who received chemotherapy, targeted therapy, pulmonary radiotherapy, and pulmonary surgery had longer TPDBM. For BC patients, age ≥ 50 years, Ki67 ≥ 0.3, HER2 positive or triple‐negative breast cancer subtype, advanced N stage, and no mastectomy were correlated with shorter TPDBM.ConclusionsThis single‐institutional study helps identify patients who have a high risk of developing BM early. For these patients, early detection and intervention could have clinical benefits.
Predictive capacity of immune‐related adverse events and cytokine profiling in neoadjuvant immune checkpoint inhibitor trials for head and neck squamous cell carcinoma
Authors: Alnemri Angela E. , Tekumalla Sruti , Moroco Annie E. , Vathiotis Ioannis , Tuluc Madalina , Gargano Stacey , Zhan Tingting , Cognetti David M. , Curry Joseph M. , Argiris Athanassios , Linnenbach Alban , South Andrew P. , Harshyne Larry A. , Johnson Jennifer M. , Luginbuhl Adam J. 
Published: June 2024

AbstractObjectivesCertain low‐level immune‐related adverse events (irAEs) have been associated with survival benefits in patients with various solid tumors on immune checkpoint inhibitors (ICIs). We aimed to investigate the association between irAEs and response to neoadjuvant ICIs in patients with head and neck squamous cell carcinoma (HNSCC) and to identify differences in circulating cytokine levels based on irAE status.MethodsThis was a retrospective cohort study including three neoadjuvant clinical trials from July 2017 to January 2022: NCT03238365 (nivolumab ± tadalafil), NCT03854032 (nivolumab ± BMS986205), NCT03618654 (durvalumab ± metformin). The presence and type of irAEs, pathologic treatment response, and survival were compared. Canonical linear discriminant analysis (LDA) was performed to identify combinations of circulating cytokines predictive of irAEs using plasma sample multiplex assay.ResultsOf 113 participants meeting inclusion criteria, 32 (28.3%) developed irAEs during treatment or follow‐up. Positive p16 status was associated with irAEs (odds ratio [OR] 2.489; 95% CI 1.069–6.119; p = 0.043). irAEs were associated with pathologic treatment response (OR 3.73; 95% CI 1.34–10.35; p = 0.011) and with higher OS in the combined cohort (HR 0.319; 95% CI 0.113–0.906; p = 0.032). Patients with irAEs within the nivolumab cohort had significant elevations of select cytokines pre‐treatment. Canonical LDA identified key drivers of irAEs among all trials, which were highly predictive of future irAE status.ConclusionsirAEs are associated with response to neoadjuvant ICI therapy in HNSCC and can serve as clinical indicators for improved clinical outcomes. irAEs can be predicted by concentrations of several circulating cytokines prior to treatment.
The empathetic landscape: Examining the role of empathy in the well‐being of counsellors and psychotherapists working with trauma
Authors: Palumbo Aimie , Wezyk Agata , Woodward Alison , Panourgia Constantina 
Published: June 2024

AbstractIntroductionCounsellors and psychotherapists working with trauma experience constant exposure to clients' adverse events, placing their well‐being in jeopardy. The pivotal role of empathy in maintaining their well‐being is underscored, given the imperative for these professionals to sustain empathetic engagement with clients. However, prior research has solely focussed on other helping professions.MethodologyThis study employed semi‐structured interviews to explore the subjective experiences of 14 psychotherapists and counsellors in trauma‐informed settings regarding the role of empathy and its implications for well‐being. Reflexive thematic analysis was utilised to analyse these data.ResultsThree main themes were identified from the analysis: Empathy is crucial, empathy as a risk factor and empathy can be regulated and developed.ConclusionsThe study's findings reinforce previous research and provide new insights into empathy's development and management in the context of professional trauma work.
The Chemistry and Biology of Lycopodium Alkaloids
Authors: Zhang Zhi‐Jun , Jiang Shuai , Zhao Qin‐Shi 
Published: June 2024

AbstractLycopodiales, an order comprising 388 distinct species, is the source of Lycopodium alkaloids (LAs), a group of naturally occurring alkaloids that share a common biosynthesis and structural attributes. These remarkable organisms are considered vestiges of ancient ferns, with fossil evidence dating their existence back to an impressive 300 million years. LAs usually are tricyclic or tetracyclic compounds with C16N or C16N2 skeleton. But then there are also have a few C11N, C15N, C15N2, C22N2, and C27N3 skeleton. LAs have attracted much scientific attention because of their important biological activities related to acetylcholinesterase and unique structural characteristics. From 1881 to December 2023, there are 593 LAs from 49 species of Lycopodiales have been reported. Because the total amount of LAs is nearly five times that of 1994, the classification and group allocation of some newly isolated LAs is often challenging and not unambiguous by Ayer's simple classification. This review makes a more systematic and detailed classification for it and provides extensive coverage of naturally occurring LAs discovered from 1881 to December 2023. Until now, there is no comprehensively summary of biological activity of the LAs. This review is the first time covered the biological activity of the all LAs.
Fluorogenic in‐situ Labelling of Gelatin Polymer in Aqueous Solution and Hydrogel
Authors: Cheng Yao , Yang Yujiao , Wang Shuodong , Zhou Zhibiao , Li Jiangcan , Zhang Yang , Chen Sijie , Zeng Zebing , Xie Sheng , Tang Ben Zhong 
Published: June 2024

AbstractGelatin polymers made from partially degraded collagen are important biomaterials, but their in‐situ analysis suffers from uncontrollable covalent labelling and poor spatial‐temporal imaging resolution. Herein, three tetrazolate‐tagged tetraphenylethylene fluorophores (TPE−TAs) are introduced for practical fluorogenic labelling of gelatin in aqueous phase and hydrogels. These probes with aggregation‐induced emission characteristics offer negligible background and elicit turn‐on fluorescence by simply mixing with the gelatin in aqueous phase, giving a detection limit of 0.15 mg/L over a linear dynamic range up to 100 mg/L. This method does not work for collagens and causes minimal interference with gelatin properties. Mechanistic studies reveal a key role for multivalent electrostatic interactions between the abundant basic residues in gelatin (e. g., lysine, hydroxylysine, arginine) and anionic tetrazolate moieties of the lipophilic fluorophore synergistically in spatially rigid macromolecular encapsulation to achieve fluorogenic labelling. The AIE strategy by forming non‐covalent fluorophore‐gelatin complexes was developed for novel hydrogels that exhibited reversible fluorescence in response to dynamic microstructural changes in the hydrogel scaffold upon salting‐in/out treatments, and enabled high spatial‐temporal imaging of the fiber network in lyophilized samples. This work may open up avenues for in‐situ imaging analysis and evaluation of gelatin‐based biomaterials during processes such as in vivo degradation and mineralization.
Nickel‐Catalyzed Enantioselective Carbonyl Addition of Aryl Chlorides and Bromides to Aldehydes
Authors: Jiang Mingjie , Yu Limei , Zou Chenhui , Yuan Hao , Xu Minghui , Chen Bin , Hu Ping , Wang Bi‐Qin , Cao Peng 
Published: June 2024

AbstractThe Ni‐catalyzed enantioselective addition reaction of aryl halides to aldehydes was studied with cyanobis(oxazoline) as chiral ligands and Mn as reductant. Aryl and heteroaryl bromides reacted with phenyl aldehyde at room temperature to produce dibenzyl alcohols in 16–99 % yields with 53–92 % ees. Moreover, the coupling of phenyl chloride with a variety of aryl, heteroaryl and alkyl aldehydes was demonstrated in the presence of cyanobis(oxazoline)/Ni(II) at 60 °C in generally high yields with moderate enantioselectivities.
Early achievement of walkability after cardiac surgery and the risk of cardiovascular disease after hospital discharge
Authors: Kawamura Tomonori , Sakaniwa Ryoto , Nishimura Masato , Matsuo Yoshimi , Imai Yoshihide , Hori Yusuke , Tsukizawa Tomohumi , Fukuda Keisuke , Matsuura Makoto , Takemoto Tetsushi , Furuya Oniti , Kuroyanagi Satoshi , Higashiue Shiniti , Iso Hiroyasu , Sobue Tomotaka 
Published: June 2024

AbstractAimsThis study aimed to investigate the association between the time to achieve walkability after cardiac surgery and the risk of cardiovascular disease after hospital discharge.MethodsWe conducted a prospective cohort study involving 553 ambulatory patients aged 71.5 (range, 64.0–77.0) years who underwent cardiac surgery. All patients were divided into five groups based on the time to achieve walkability ≥100 m within 1, 2, 3, 4 or 5 days after cardiac surgery. We examined the risk of post‐cardiovascular disease outcomes, including readmission due to heart failure, ischaemic heart disease and other cardiovascular disease, according to the time to achieve walkability with reference to 5 days using the Fine and Gray regression model, considering competing risks.ResultsIn the survival curve analysis, we examined the time to experience post‐cardiovascular disease incidence after hospital discharge. During a median of 3.3 years of follow‐up, 118 patients developed cardiovascular disease. We observed a positive association between the time to achieve walkability and cardiovascular disease risk, particularly heart failure. The multivariate hazard ratios (95% confidence intervals) for heart failure readmission were N/A (not assessed due to the sample size being too small) for 1 day, 0.31 (0.10–0.99) for 2 days, 0.60 (0.21–1.79) for 3 days and 0.76 (0.22–2.72) for 4 days (P for trend = 0.032).ConclusionsThe shorter walkability achievement time was associated with a lower risk of cardiovascular diseases, more specifically heart failure readmission, among patients who underwent cardiac surgery. The time required to achieve walkability is a useful predictor for cardiovascular diseases after hospital discharge.
Predicting cardiovascular events with fluoropyrimidine chemotherapy using a standard cardiovascular risk calculator
Authors: Abiodun Aderonke , Shawe‐Taylor Marianne , Tyebally Sara , Bagkeris Emmanouil , Bajomo Omotomilola , Artico Jessica , Slater Sarah , Raisi‐Estabragh Zahra , Diamantis Nikolaos , Manisty Charlotte 
Published: June 2024

AbstractAimsFluoropyrimidine chemotherapy is important for treatment of many solid tumours but is associated with cardiotoxicity. The relationship of fluoropyrimidine‐associated cardiotoxicity (FAC) with conventional cardiovascular (CV) risk factors is poorly understood, and standard cardiovascular risk scores are not validated in this context.Methods and resultsSingle‐centre retrospective study of patients treated with fluoropyrimidine chemotherapy using electronic health records for cardiovascular risk factors (and calculation of QRISK3 score), cancer treatment, and clinical outcomes. FAC was defined by cardiovascular events during or within 3 months of fluoropyrimidine treatment, and Cox regression was used to assess associations of CV risk and cancer treatment with FAC. One thousand eight hundred ninety‐eight patients were included (45% male; median age 64 years), with median follow up 24.5 (11.5–48.3 months); 52.7% of patients were at moderate or high baseline CV risk (QRISK3 score >10%) Cardiovascular events occurred in 3.1% (59/1898)—most commonly angina (64.4%, 38/59) and atrial fibrillation (13.6%, 8/59), with 39% events during cycle one of treatment. In univariable analysis, QRISK3 score >20% was significantly associated with incident FAC (HR 2.25, 95% CI 1.11–4.93, P = 0.03). On multivariable analysis, beta‐blocker use (HR 1.04, 95% CI 1.00–1.08, P = 0.04) and higher BMI (HR 2.33, 95% CI 1.04–5.19, P = 0.04) were independently associated with incident CV events. Thirty‐two of the 59 patients with FAC were subsequently rechallenged with fluoropyrimidine chemotherapy, with repeat CV events in 6% (2/32). Incident FAC did not affect overall survival (P = 0.50).ConclusionsHigh BMI and use of beta‐blockers are associated with risk of CV events during fluoropyrimidine chemotherapy. QRISK3 score may also play a role in identifying patients at high risk of CV events during fluoropyrimidine chemotherapy. Re‐challenge with further fluoropyrimidine chemotherapy can be considered in patients following CV events during prior treatment.
Computed versus experimental energy barriers in solution: Influence of the type of the density functional approximation
Authors: Denjean Aurore E. F. , Rio Jordan , Ciofini Ilaria , Perrin Marie‐Eve L. , Payard Pierre‐Adrien 
Published: June 2024

AbstractMechanistic investigations at the density functional theory level of organic and organometallic reactions in solution are now broadly accessible and routinely implemented to complement experimental investigations. The selection of an appropriate functional among the plethora of developed ones is the first challenge on the way to reliable energy barrier calculations. To provide guidelines for the choice of an initial and reliable computational level, the performances of commonly used non‐empirical (PBE, PBE0, PBE0‐DH) and empirical density functionals (BLYP, B3LYP, B2PLYP) were evaluated relative to experimental activation enthalpies. Most reactivity databases to assess density functional performances are primarily based on high level calculations, here a set of experimental activation enthalpies of organic and organometallic reactions performed in solution were selected from the literature. As a general trend, the non‐empirical functionals outperform the empirical ones. The most accurate energy barriers are obtained with hybrid PBE0 and double‐hybrid PBE0‐DH density functionals, both providing similar performance. Regardless of the functional under consideration, the addition of the GD3‐BJ empirical dispersion correction does not enhance the accuracy of computed energy barriers.
The combined effect of cardiorespiratory and muscular fitness on the incidence of metabolic syndrome before midlife
Authors: Tsai Kun‐Zhe , Chu Chen‐Chih , Huang Wei‐Chun , Sui Xuemei , Lavie Carl J. , Lin Gen‐Min 
Published: June 2024

AbstractBackgroundCardiorespiratory fitness (CRF) could reduce the risk of metabolic syndrome (MetS) while the association between muscular endurance capacity (MEC) and incident MetS has rarely been investigated in young adults.MethodsA total of 2890 military men and women, aged 18–39 years, free of baseline MetS in Taiwan, were followed for incident MetS from baseline (2014) until the end of 2020. All subjects received annual health examinations for assessment of MetS. Physical fitness was assessed by CRF (estimated maximal oxygen uptake, VO2 max [mL/kg/min], in a 3000‐m run) and MEC (numbers of 2‐min push‐ups). MetS was defined according to the International Diabetes Federation (IDF) criteria. Multiple Cox regression analysis was conducted with adjustments for baseline age, sex, substance use status and physical activity to determine the associations of CRF and MEC with incidences of new‐onset MetS and related features, for example, central obesity, hypertension, dyslipidaemia and prediabetes or diabetes. To examine the combined effects of CRF and MEC status on incidence of MetS, high and low levels of CRF and MEC were separately defined by over and under the sex‐specific median in each exercise test.ResultsDuring a median follow‐up of 5.8 years, there were 673 (23.3%) new‐onset MetS. Higher CRF was associated with a lower incidence of MetS (hazard ratio [HR] and 95% confidence interval: 0.905 [0.877–0.933]), and its components separately, except hypertension. No association was observed between MEC and incident MetS, and its components separately, except hypertension. When evaluating the combined effects of MEC and CRF status on the incidence of MetS, it was observed that compared with the low CRF/low MEC, the high CRF/high MEC (HR: 0.553 [0.439–0.697]) and the high CRF/low MEC (HR: 0.730 [0.580–0.918]) had a lower incidence of new‐onset MetS (P value for the intergroup difference = 0.04). There was no significant result for the low CRF/high MEC.ConclusionsThis study highlights that although the protective effects of MEC to reduce the incidence of MetS and most of its related features were mainly driven by CRF in young adults, there was an addictive effect of greater MEC on CRF to prevent the development of new‐onset MetS before midlife.
Cover Image, Volume 99, Issue 7
Authors: Kutlar Feride Ece , Engin Iskin , Yilmazel Yasemin Dilsad 
Published: June 2024

The cover image is based on the Research Article Nutrient recovery from manure digestate by using waste magnesite powder and bone meal as sustainable substitutes for struvite precipitation by Feride Ece Kutlar et al., https://doi.org/10.1002/jctb.7661.
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Defining the Sheldon Creek Formation, a Middle Wisconsinan (MIS 3) till in Iowa, USA
Authors: Tassier‐Surine STEPHANIE A. , Kerr PHILLIP J. , Kilgore SUSAN M. , Cramer BRADLEY D. 
Published: June 2024

ABSTRACTA pre‐Late Wisconsinan, post‐Illinoian, till sheet has long been recognized in north‐central Iowa, but has not been formally recognized or defined until now. Early researchers referred to these deposits as the ‘Tazewell’, and the term ‘Sheldon Creek’ was more recently used informally by the Iowa Geological Survey in guidebooks and reports. Recent mapping has extended the eastern margin significantly past previous interpretations. The Sheldon Creek Formation has similar lithologic characteristics to the overlying Alden Member of the Dows Formation, and the two units are distinguished mainly by stratigraphic position. Differentiation from underlying Pre‐Illinoian till units is accomplished using lithology, primarily matrix grain‐size and sand fraction lithology. A suite of 22 radiocarbon ages indicate two distinct, separate groupings within the Sheldon Creek data. These data strongly suggest ice advanced south to 42° N twice, once during Marine Isotope Stage (MIS) 3 and again during late MIS 3 or possibly early MIS 2. The presence of the Laurentide Ice Sheet in northern Iowa during MIS 3 has significant implications for ice sheet reconstructions during this interval.
Impact of non‐palm triglyceride feedstocks on surfactant properties and consumer product applications
Authors: Falk Nancy 
Published: June 2024

AbstractIncreased demand and sustainability concerns for palm derivatives, which include the major plant‐based feedstocks for surfactants in household, personal care, and industrial & institutional (I&I) applications, is anticipated to cause supply concerns over the next decade. This article reviews the impact of the fatty acid alkyl chain length and unsaturation and resulting physical properties from non‐palm feedstocks on formulation, processing, and functionality. Potential adjustments and their limitations are also discussed.
Singular solutions for Lane–Emden equations with CKN operator
Authors: Chen Huyuan , Sun Yanqing , Wang Ying 
Published: June 2024

AbstractIn this paper, we concern the isolated singular solutions for Lane–Emden equations involving the CKN operator

We classify the isolated singularities by building the connection with the equations involving the Dirac mass in a weighted distributional sense. Then, we obtain the minimal singular solution with given singularities at the origin, analyze the stability of the minimal singular solutions. Finally, we can derive a second solution by the variational method with the given singularities.
Fredholm theory of the Toeplitz algebra on the space of all entire functions
Authors: Jasiczak M. 
Published: June 2024

AbstractWe prove that an aggregate Toeplitz operator on the Fréchet space of all entire functions is a Fredholm operator if and only if its symbol does not vanish. The result is motivated by and closely resembles the classical result of Gohberg and Douglas from the Hardy space theory of Toeplitz operators. There are however some subtle differences which we also discuss.