bluuebunny/crossref_metadata_2025_split huggingface dataset:
Speaking Credibly? Communicating Christian Particularism in Postmodern Contexts
Authors: Stanley Timothy 
Published: March 2009

AbstractHow can Christian particularism be credibly discussed in postmodern culture? The answer to this question does not necessarily demand an abandonment of the particular salvific claims of the Christian tradition. This essay explores the cultural and philosophical subtext of religious pluralism in order to discuss religious particularity in a more credible way. If Christians are faithfully to articulate their own particularity, they must first seek to understand the way postmodernity's emancipatory strategies have co‐opted the category of religion. Though modernity's quest for political and social emancipation is not a novel thesis, the elucidation of how emancipation in modernity has been radicalized in postmodernity offers new insight into the cultural context within which Christum traditions now find themselves. By explicating the relationship between freedom and religious pluralism in postmodernity, we can begin to see that by gaining a more thoughtful understanding of freedom we can develop more adept strategies for communicating Christian particularity. In this regard, the Christian doctrine of the Trinity may play a crucial role.
Recovering Missional Ecclesiology in Theological Education
Authors: Laing Mark 
Published: March 2009

AbstractThe first part of this paper seeks to demonstrate how predominant Christianity, under Christendom, divorced mission from ecclesiology, and marginalized missiology from the theological curriculum. This is not only a problem for the west, as this model was then exported and replicated worldwide through the agency of the Protestant missionary movement. In the second part the paper explores the factors which have led us to a more adequate ecclesiology. Since we have recovered the missionary dimension in ecclesiology the paper argues that this must also be reflected in our theological curriculum.
Beyond Four‐Walled Campuses: Models of Ecumenical Theological Education in Interfaith Issues in India
Authors: Longchar Wati 
Published: March 2009

AbstractThis article examines the relevancy of three education system models – professional or university, banking or teacher‐centred, and campus or residential – from an inter‐religious perspective. These models are no longer adequate in a multi‐religious context and a shift is imperative. We need to evolve a model of education “together with people”, which includes all sections of the society – rich and poor, young and old, Christians and non‐Christians. An inclusive curriculum that affirms plurality/diversity and the common good is urgently needed. This must take place within the larger academic world. A theological education in interaction with the secular learning process will contribute to reinforcing moral and ethical values in society for the common good.
Theological Reconstruction in China: Ecumenical Accompaniment in the Self‐Theologizing Effort in Theological Education
Authors: Wilson Henry S. 
Published: March 2009

AbstractIn 2007 Protestants in China celebrated the 200th anniversary of their journey of faith. The continuing concern of Chinese Christian theological educators is to rejuvenate Christianity in China by critically adapting to the contemporary socialist order and the best religio‐cultural tradition of Chinese society. Chinese Christians have been challenged by the socialist order of society particularly because of the political and social changes that have taken place in China since the establishment of the People's Republic of China in 1949 and the changes brought about within Chinese society. With the end of the Cultural Revolution (1966–1976) and the change of political atmosphere in 1978 there has been once again an opening for public Christian activities within the confines of certain state regulations. This change has provided scope for pursuing the reconstruction in China of Christianity initiated in the 1950s under the Three Self Patriotic Movement (TSPM). Besides the revival of TSPM, the Chinese leaders have set up another instrument, the China Christian Council (CCC) especially to cater to the surging pastoral and congregational needs. This article briefly surveys the development of the vision of reconstructing Christianity through “theological reconstruction” and the need for ecumenical accompaniment.
Towards a Relevant Paradigm of Theological Education for an Effective Christian Mission in South East Asia: An Attempt at Re‐engineering the South East Asia Graduate School of Theology
Authors: Po Ho Huang 
Published: March 2009

AbstractThe advanced theological education implemented in Asia through area cooperation in order to overcome the limitation of personnel, experiences and educational resources, i.e. South East Asia Graduate School of Theology (SEAGST), has come to a turning point under the influence of factors within and outside. The challenges of the popularity of religious studies in universities, and the readiness of many of the local theological institutes to offer higher theological degree programmes, raised questions about the quality and legitimacy of the current area setup (more and more participating schools are launching their own advanced theological degrees, which creates an overlapping of programmes). While recognizing the strengths of the current model for contextual concerns, the need for reviewing and re‐engineering the SEAGST to a more relevant model of theological education for the churches and societies in Asia has been discussed widely. This article proposes the idea of a supplementary centre or centres to the current area setup, so that the current strengths will be preserved and its weaknesses can be remedied.
Major Challenges for African Women Theologians in Theological Education (1989–2008)
Authors: Phiri Isabel Apawo 
Published: March 2009

AbstractThe paper reflects on the major challenges for African women theologians in theological education as presented and experienced in the Circle of Concerned African Women Theologians (“Circle”) which was launched in Ghana in 1989 as a community of African women theologians who come together to reflect on what it means to them to be women of faith within their experiences of religion, culture, politics and social‐economic structures in Africa. Four major challenges are identified that African women theologians have had to contend with and which are still present, namely (1) re‐defining the identity of African women theologians; (2) promoting more women to study theology and be on permanent staff; (3) inclusion of African women's theology in the theological curriculum; and (4) collaboration with male theologians.
Ionized Hypercalcemia in Dogs: A Retrospective Study of 109 Cases (1998–2003)
Authors: Messinger J.S. , Windham W.R. , Ward C.R. 
Published: March 2009

Background:Serum hypercalcemia in dogs has been reported in association with a variety of diseases. Serum‐ionized calcium (iCa) concentration is a more accurate measure of hypercalcemia than total serum calcium or corrected serum calcium concentrations. The severity of hypercalcemia has been utilized to suggest the most likely differential diagnosis for the hypercalcemia.Hypothesis:Diseases causing ionized hypercalcemia may be different than those that cause increases in total or corrected serum calcium concentrations. The severity of ionized hypercalcemia in specific diseases cannot be used to determine the most likely differential diagnosis for ionized hypercalcemia.Animals:One‐hundred and nine client‐owned dogs with a definitive cause for their ionized hypercalcemia evaluated between 1998 and 2003 were included in this study.Methods:Retrospective, medical records review.Results:Neoplasia, specifically lymphosarcoma, followed by renal failure, hyperparathyroidism, and hypoadrenocorticism were the most common causes of ionized hypercalcemia. Dogs with lymphoma and anal sac adenocarcinoma have higher serum iCa concentrations than those with renal failure, hypoadrenocorticism, and other types of neoplasia. The magnitude of serum‐ionized hypercalcemia did not predict specific disease states.Conclusions and Clinical Importance:Serum‐ionized hypercalcemia was most commonly associated with neoplasia, specifically lymphosarcoma. Although dogs with lymphosarcoma and anal sac adenocarcinoma had higher serum iCa concentrations than dogs with other diseases, the magnitude of the serum iCa concentration could not be used to predict the cause of hypercalcemia. Total serum calcium and corrected calcium concentrations did not accurately reflect the calcium status of the dogs in this study.
Asparaginase and MOPP Treatment of Dogs with Lymphoma
Authors: Brodsky E.M. , Maudlin G.N. , Lachowicz J.L. , Post G.S. 
Published: March 2009

Background:Dogs with multicentric lymphoma are treated with various cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP)‐based chemotherapy protocols with variable success.Objectives:To describe the progression‐free survival (PFS) time and overall survival time (OST) of dogs with T‐cell lymphoma or hypercalcemic lymphoma treated withl‐asparaginase and mechlorethamine, vincristine, prednisone, procarbazine (MOPP).Animals:Fifty dogs with T‐cell lymphoma, hypercalcemic lymphoma, or both treated at 3 referral veterinary hospitals.Methods:Retrospective study. Case were selected based on histologic or cytologic diagnosis of lymphoma; presence of the T‐cell phenotype, presence of hypercalcemia or both; and absence of previous chemotherapy. The T‐cell phenotype was determined by flow cytometry, immunocytochemistry, immunohistochemistry, or polymerase chain reaction of antigen receptor rearrangement.Results:The overall response rate was 98% (78% complete response, 20% partial response). The median PFS for the entire study population was 189 days with 25% PFS at 939 days. The median OST for the entire study population was 270 days with 25% surviving 939 days. Twenty percent of the dogs required hospitalization for treatment related complications.Conclusions and clinical importance:l‐Asp/MOPP chemotherapy might result in longer PFS and OST for dogs with multicentric T‐cell lymphoma, dogs with hypercalcemic lymphoma or both, than achieved with CHOP.
The Korean Peninsula Peace Regime: How to Build It
Authors: Kwak Tae‐Hwan 
Published: March 2009

A Korean peninsula peace regime has not yet been established, over a half century since the Korean armistice agreement. Two approaches to a Korean peninsula peace‐regime‐building process are required: inter‐Korean and international approaches. The two Koreas should play leading roles at the inter‐Korean and international levels in inter‐Korean confidence‐building measures by reducing tension through reconciliation and economic cooperation. A Korean peace forum involving the USA, China and the two Koreas under the 19 September joint agreement could conclude a Korean peninsula peace treaty to replace the armistice agreement and a peace regime could be institutionalized by implementing the inter‐Korean basic agreement (1992) through inter‐Korean cooperation.This article proposes a comprehensive, long‐term roadmap for the Korean peninsula peace‐regime‐building process. The author makes three major arguments. First, the two Koreas and the four powers need to agree on a comprehensive roadmap for the Korean peninsula peace‐regime‐building process as suggested here. The inter‐Korean and international approaches to the peace‐regime‐building process should be considered in parallel. Second, the North Korean nuclear issue should be resolved peacefully through the Six‐Party Talks. Third, the two Koreas need to work together to find an alternative to their respective proposals. The author proposes a Korean peninsula peace treaty signed by the ROK, the DPRK, the USA and China as an alternative. Unless the two Koreas demonstrate their desire to cooperate through sincere deeds by implementing inter‐Korean agreements and are willing to make concessions by working together for establishing a peace regime in Korea, there is little chance of achieving this goal.
Formule du conducteur pour un caractère l-adique
Authors: Vidal Isabelle 
Published: March 2009

AbstractLetKbe a local field of equal characteristicp&gt;2, letXK/Kbe a smooth proper relative curve, and letbe a rank 1 smoothl-adic sheaf (l≠p) on a dense open subsetUKXK. In this paper, under some assumptions on the wild ramification of, we prove a conductor formula that computes the Swan conductor of the etale cohomology of the vanishing cycles of. Our conductor formula is a generalization of the conductor formula of Bloch, but for non-constant coefficients.
Validation of tissue microarray technology in malignant peripheral nerve sheath tumours
Authors: Cunha K Soares Gonçalves , Caruso A Cunha , Gonçalves A Soares , Bernardo V Gonçalves , Pires A Rodrigues Cordovil , da Fonseca E Carvalho , de Faria P Antônio Silvestre , da Silva L Esmeraldo , Geller M , de Moura-Neto R Soares , Lopes V Silami 
Published: March 2009

Background:It has been suggested that the donor tissue cores used in tissue microarrays (TMAs) may not be representative of the whole tissue section.Aim:To validate the use of TMA technology in the study of malignant peripheral nerve sheath tumours (MPNSTs).Methods:A TMA was constructed containing five independent core biopsy samples of 14 formalin-fixed, paraffin-embedded MPNSTs. The immunohistochemical (IHC) results of the five cores from the same tissue block on TMA were compared with readings from whole sections using two antibodies: anti-Ki-67 and anti-S-100. Digital image analysis was performed to calculate the percentage of positive stain areas. The agreement between IHC results obtained with TMA cores and whole sections was assessed using the κ statistic.Results:There was good to very good agreement between IHC results for whole and TMA sections from MPNSTs. In relation to S-100, very good agreement (92% agreement; κ = 0.77) was observed using a minimum of four TMA cores. Staining results for Ki-67 from at least four readable TMA cores were the same as those for the whole section in 86% of cases, with good agreement, using weighted κ statistics (κ = 0.63).Conclusions:This study indicates that the TMA technique can be used in the IHC study of MPNSTs, even with the use of heterogeneous markers such as S-100 protein.
FREE BROWNIAN MOTION AND EVOLUTION TOWARDS ⊞-INFINITE DIVISIBILITY FOR k-TUPLES
Authors: BELINSCHI SERBAN T. , NICA ALEXANDRU 
Published: March 2009

Let [Formula: see text] be the space of non-commutative distributions of k-tuples of self-adjoint elements in a C*-probability space. For every t ≥ 0 we consider the transformation [Formula: see text] defined by [Formula: see text] where ⊞ and ⊎ are the operations of free additive convolution and respectively of Boolean convolution on [Formula: see text]. We prove that 𝔹s◦ 𝔹t= 𝔹s + t, for all s, t ≥ 0. For t = 1, we prove that [Formula: see text] is precisely the set [Formula: see text] of distributions in [Formula: see text] which are infinitely divisible with respect to ⊞, and that the map [Formula: see text] coincides with the multi-variable Boolean Bercovici–Pata bijection put into evidence in our previous paper [1]. Thus for a fixed [Formula: see text], the process {𝔹t(μ)|t ≥ 0} can be viewed as some kind of "evolution towards ⊞-infinite divisibility".On the other hand, we put into evidence a relation between the transformations ⊞tand free Brownian motion. More precisely, we introduce a map [Formula: see text] which transforms the free Brownian motion started at an arbitrary [Formula: see text] into the process {𝔹t(μ)|t ≥ 0} for μ = Φ(ν).
A Key Regulatory Role of the Transcription Factor NFATc2 in Bronchial Adenocarcinoma via CD8+ T Lymphocytes
Authors: Maxeiner Joachim H. , Karwot Roman , Sauer Kerstin , Scholtes Petra , Boross Ildiko , Koslowski Michael , Türeci Özlem , Wiewrodt Rainer , Neurath Markus F. , Lehr Hans A. , Finotto Susetta 
Published: March 2009

AbstractThe Ca2+-regulated calcineurin/nuclear factor of activated T cells (NFAT) cascade controls alternative pathways of T-cell activation and peripheral tolerance. Here, we describe reduction of NFATc2 mRNA expression in the lungs of patients with bronchial adenocarcinoma. In a murine model of bronchoalveolar adenocarcinoma, mice lacking NFATc2 developed more and larger solid tumors than wild-type littermates. The extent of central tumor necrosis was decreased in the tumors in NFATc2(−/−) mice, and this finding was associated with reduced tumor necrosis factor-α and interleukin-2 (IL-2) production by CD8+ T cells. Adoptive transfer of CD8+ T cells of NFATc2(−/−) mice induced transforming growth factor-β1 in the airways of recipient mice, thus supporting CD4+CD25+Foxp-3+glucocorticoid-induced tumor necrosis factor receptor (GITR)+ regulatory T (Treg) cell survival. Finally, engagement of GITR in NFATc2(−/−) mice induced IFN-γ levels in the airways, reversed the suppression by Treg cells, and costimulated effector CD4+CD25+ (IL-2Rα) and memory CD4+CD127+ (IL-7Rα) T cells, resulting in abrogation of carcinoma progression. Agonistic signaling through GITR, in the absence of NFATc2, thus emerges as a novel possible strategy for the treatment of human bronchial adenocarcinoma in the absence of NFATc2 by enhancing IL-2Rα+ effector and IL-7Rα+ memory-expressing T cells. [Cancer Res 2009;69(7):3069–76]
Programmed Cell Death Protein 4 Down-regulates Y-Box Binding Protein-1 Expression via a Direct Interaction with Twist1 to Suppress Cancer Cell Growth
Authors: Shiota Masaki , Izumi Hiroto , Tanimoto Akihide , Takahashi Mayu , Miyamoto Naoya , Kashiwagi Eiji , Kidani Akihiko , Hirano Gen , Masubuchi Daisuke , Fukunaka Yasushi , Yasuniwa Yoshihiro , Naito Seiji , Nishizawa Shigeru , Sasaguri Yasuyuki , Kohno Kimitoshi 
Published: March 2009

Abstract
Programmed cell death protein 4 (PDCD4) has recently been shown to be involved in both transcription and translation, and to regulate cell growth. However, the mechanisms underlying PDCD4 function are not well understood. In this study, we show that PDCD4 interacts directly with the transcription factor Twist1 and leads to reduced cell growth through the down-regulation of the Twist1 target gene Y-box binding protein-1 (YB-1). PDCD4 interacts with the DNA binding domain of Twist1, inhibiting its DNA binding ability and YB-1 expression. Immunohistochemical analysis showed that an inverse correlation between nuclear PDCD4 and YB-1 expression levels was observed in 37 clinical prostate cancer specimens. Growth suppression by PDCD4 expression was completely recovered by either Twist1 or YB-1 expression. Moreover, PDCD4-overexpressing cells are sensitive to cisplatin and paclitaxel but not to etoposide or 5-fluorouracil. In summary, PDCD4 negatively regulates YB-1 expression via its interaction with Twist1 and is involved in cancer cell growth and chemoresistance. [Cancer Res 2009;69(7):3148–56]
The Human Cytomegalovirus–Encoded Chemokine Receptor US28 Promotes Angiogenesis and Tumor Formation via Cyclooxygenase-2
Authors: Maussang David , Langemeijer Ellen , Fitzsimons Carlos P. , Stigter-van Walsum Marijke , Dijkman Remco , Borg Martin K. , Slinger Erik , Schreiber Andreas , Michel Detlef , Tensen Cornelis P. , van Dongen Guus A.M.S. , Leurs Rob , Smit Martine J. 
Published: March 2009

Abstract
The human cytomegalovirus (HCMV), potentially associated with the development of malignancies, encodes the constitutively active chemokine receptor US28. Previously, we have shown that US28 expression induces an oncogenic phenotype both in vitro and in vivo. Microarray analysis revealed differential expression of genes involved in oncogenic signaling in US28-expressing NIH-3T3 cells. In particular, the expression of cyclooxygenase-2 (COX-2), a key mediator of inflammatory diseases and major determinant in several forms of cancer, was highly up-regulated. US28 induced increases in COX-2 expression via activation of nuclear factor-κB, driving the production of vascular endothelial growth factor. Also, in HCMV-infected cells, US28 contributed to the viral induction of COX-2. Finally, the involvement of COX-2 in US28-mediated tumor formation was evaluated using the COX-2 selective inhibitor Celecoxib. Targeting COX-2 in vivo with Celecoxib led to a marked delay in the onset of tumor formation in nude mice injected with US28-transfected NIH-3T3 cells and a reduction of subsequent growth by repressing the US28-induced angiogenic activity. Hence, the development of HCMV-related proliferative diseases may partially be ascribed to the ability of US28 to activate COX-2. [Cancer Res 2009;69(7):2861–9]
14-3-3ζ Overexpression Defines High Risk for Breast Cancer Recurrence and Promotes Cancer Cell Survival
Authors: Neal Christopher L. , Yao Jun , Yang Wentao , Zhou Xiaoyan , Nguyen Nina T. , Lu Jing , Danes Christopher G. , Guo Hua , Lan Keng-Hsueh , Ensor Joe , Hittelman Walter , Hung Mien-Chie , Yu Dihua 
Published: March 2009

Abstract
The ubiquitously expressed 14-3-3 proteins are involved in numerous important cellular functions. The loss of 14-3-3σ is a common event in breast cancer; however, the role of other 14-3-3s in breast cancer is unclear. Recently, we found that 14-3-3ζ overexpression occurs in early stage breast diseases and contributes to transformation of human mammary epithelial cells. Here, we show that 14-3-3ζ overexpression also persisted in invasive ductal carcinoma and contributed to the further progression of breast cancer. To examine the clinical effect of 14-3-3ζ overexpression in advanced stage breast cancer, we performed immunohistochemical analysis of 14-3-3ζ expression in primary breast carcinomas. 14-3-3ζ overexpression occurred in 42% of breast tumors and was determined to be an independent prognostic factor for reduced disease-free survival. 14-3-3ζ overexpression combined with ErbB2 overexpression and positive lymph node status identified a subgroup of patients at high risk for developing distant metastasis. To investigate whether 14-3-3ζ overexpression causally promotes breast cancer progression, we overexpressed 14-3-3ζ by stable transfection or reduced 14-3-3ζ expression by siRNA in cancer cell lines. Increased 14-3-3ζ expression enhanced anchorage-independent growth and inhibited stress-induced apoptosis, whereas down-regulation of 14-3-3ζ reduced anchorage-independent growth and sensitized cells to stress-induced apoptosis via the mitochondrial apoptotic pathway. Transient blockade of 14-3-3ζ expression by siRNA in cancer cells effectively reduced the onset and growth of tumor xenografts in vivo. Therefore, 14-3-3ζ overexpression is a novel molecular marker for disease recurrence in breast cancer patients and may serve as an effective therapeutic target in patients whose tumors overexpress 14-3-3ζ. [Cancer Res 2009;69(8):3425–32]