bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation between basal IOP and functional damage in three different types of open angle glaucoma (OAG)
Authors: CASTEJON M , BOLIVAR G , AREVALO‐SERRANO J , ARRANZ‐MARQUEZ E , TEUS MA 
Published: November 2010

Abstract Purpose To analyze the correlation between basal, untreated IOP and visual field damage in newly diagnosed Hyperbaric glaucoma (HB), Focal damage glaucoma (FG) and pseudoexfoliative glaucoma (PEXG). Methods This is a prospective, cross sectional study. Basal, untreated IOP was measured in all cases. The Retinal fiber layer (RNFL) thickness was measured using the OCT stratus 3.0 and the fast RNFL thickness strategy. Visual field was evaluated using the Humphrey field analyzer, achromatic perimetry, SITA standard 24‐2 strategy. Corneal pachimetry was measured in all eyes. Only one eye per patient was included. Linear regression analyses and Pearson’s correlation coefficients between the basal IOP and the global Visual Field (VF) indices were performed. The ANOVA test was used for comparison of the means of quantitative parameters. Results 36 HB, 43 GF and 28 PEXG eyes were included in the study. Untreated IOP was 30.9 mmHg in HB, 19.1 mmHg in FG, and 24.5 mmHg in PEXG eyes. (p=0.0001 for all comparisons). Central corneal thickness was also different in each group. PEXG eyes had the thicker corneas (568.56 microns) and FG had the thinnest corneas (527.43 microns). No significant difference was found in the RNFL thickness or in the Mean Defect of the visual field between groups. Basal IOP was significantly correlated with the VF Mean Defect in HG (p=0.006, r=0.44) and in PEXG (p=0.002, r=0.55). No statistically significant correlation was found between both parameters in FG eyes. Conclusion Different types of Open Angle Glaucomas with a similar degree of glaucomatous damage, show a different correlation between untreated IOP and visual field damage.
A comparison of perimetric results with standard automated perimetry and HEP perimetry in a group of glaucomatous patients
Authors: GIL ARRIBAS L , CALVO P , FERRERAS A , OTIN S , ALTEMIR I , FERNANDEZ S , GUERRI MONCLUS N , PRIETO E , EGEA ESTOPINAN MC , GARCIA‐MARTIN E , IDOIPE M 
Published: November 2010

Abstract Purpose To compare the results obtained between Humphrey Perimeter (Carl Zeiss Meditec, EEUU) and Heidelberg Edge Perimeter (HEP, Heidelberg Engineering, Alemania) tested in a group of glaucomatous patients. Methods A total of 23 eyes of 23 glaucomatous patients were prospectively and consecutively selected. All of them had basal IOP values higher than 20 mmHg and glaucomatous optic nerve head. They were examined with Standard Automated Perimetry (SAP) using 24‐2 SITA standard and HEP perimetry using 24‐2 ASTA standard algorithm. They performed at least one reliable perimetry with each device. Spearman‘s correlation coefficients were calculated between global indices of both devices: mean deviation (MD), pattern standard deviation (PSD) and visual field index (VFI). Results Mean age was of 65.07±8.67 years. Subjects had mean IOP values of 24.43±1.90 mmHg. The mean MD values were ‐6.73±6.23 and ‐2.89±3.26 measured with Humphrey and HEP perimeters respectively. And the mean PSD values were 6.07±3.62 and 3.80±2.45 measured with Humphrey and HEP perimeters respectively. The strongest correlations were observed between MDs (0.683; p=0.001) and between PSDs (0.619; p=0.003). Conclusion Humphrey and HEP perimeter correlated well in some global values. Further studies are required to evaluate the clinical usefulness of HEP perimeter in glaucoma patients.
Analysis of progression with PeriDataTM and guided progression analysis (GPA) in glaucoma patients: interim analysis
Authors: FORTUNATI M , POURJAVAN S 
Published: November 2010

Abstract Purpose To compare the rate of progression of GPA with the progression analysis calculated by PeriData in a mixed glaucoma group. Methods Retrospective, observational study including 32 eyes (number needed: 76 eyes) of 17 known glaucoma patients with at least 5 reliable visual field examinations in minimum 2 years. Patients who underwent filtering surgery or laser trabeculoplasty during the follow‐up period were excluded. Results Mean age was 70 ±18 yrs. Each patient performed a mean number of 13 ±4.6 (range: 9 to 28) standard automated perimetry visual test (Sita Standard 24‐2) per eye and with a mean follow‐up of 7.5 ± 1.3 yrs. The mean of progression by PeriData (dB/year) and GPA (%/year) were: ‐0.2 ± 0.38 and ‐0.55 ± 0.71 respectively. This difference in progression was not significantly different (p value= 0.06) There was an excellent correlation between Peridata progression analysis and GPA (<0.001). Conclusion Rate of progression with GPA and progression analysis of PeriData are two trend analysis. This could explain the excellent correlation. They represent complementary information and methods for progression of VF. To date, our results didn’t show significant difference between GPA and PeriData.
Relationship between flicker FDF perimetry and standard automated perimetry in glaucoma patients
Authors: CALVO PEREZ P , GIL‐ARRIBAS L , FERRERAS A , ALTEMIR I , OTIN S , FERNANDEZ S , GARCIA E , GUERRI MONCLUS N 
Published: November 2010

Abstract Purpose To compare the main indices of flicker FDF perimetry (FDF, Heidelberg Engineering, Germany) with standard automated perimetry (SAP) in glaucoma patients. Methods Twenty‐three open‐angle glaucoma patients were prospectively and consecutively selected. Glaucomatous patients had an intraocular pressure higher than 21 mmHg and glaucomatous optic disc appearance. All of them underwent at least one reliable perimetry with each device. SAPs were performed with a FDF perimeter (24‐2 ASTA‐Standard test) and Humphrey perimeter (Carl Zeiss (24‐2 SITA standard algorithm). The Kolmogorov Smirnov test was applied to check that the data were normally distributed. Only one eye per subject was included in the study. Spearman correlations were calculated between both devices : mean deviation (MD), pattern standard deviation (PSD), and visual field index (VFI). Results : Mean age was 65.07±8.67 years. MD of SAP was ‐6.73 ± 6.23 dB, and MD of FDF was ‐7.70 ± 5.84 dB (p=0,123); PSD of SAP was 6.07 ± 3.62, and PSD of FDF was 3.91 ± 1.89 (p = 0.953). The correlations between MDs were 0.736 (p<0.001) and between PSDs were 0.320 (p>0.05) Conclusion Moderate correlations were found between main visual field indices both devices. Altough no differences were found, FDF tends to present MD values lower than Humphrey.
Evaluation of the optic nerve in early glaucoma diagnosis: standard automated perimetry, short‐wavelength automated perimetry, frequency doubling technology, pattern electroretinogram and visual evoked potential in glaucoma suspects
Authors: MILANO G , BOSSOLESI L , COLOMBO M , RAIMONDI M , BORDIN M , LANTERI S , ROSSI GCM 
Published: November 2010

Abstract Purpose To compare the ability of different functional tests in detecting early glaucomatous damage Methods 68 randomly selected patients screened by the glaucoma unit of the University Eye Clinic of Pavia were considered glaucoma suspects on the basis of the IOP and the morphometric analysis of the optic nerve with GDx‐VCC and HRT‐III. They were submitted to SAP and divided into two age‐matched groups according to Glaucoma Staging System II: group A (45 subjects, mean age 62±8 y) with GSSII 0 (MD≤‐2dB, PSD<2.7dB) and group B (23 subjects , mean age 64±6 y) with GSSII ≤ 2 (MD≤‐10dB, PSD≤9dB). The two groups were then submitted to a complete evaluation of the optic nerve function based on SWAP, FDT, PERG, VEP. Number of points significantly depressed <5% and <1% in the pattern deviation plot,MD,PSD, and test duration for all perimetric tests, amplitude and latency of P50 and N95 for PERG and P100 for VEP were compared using the Wilcoxon signed rank test Results All parameters of SAP and SWAP pointed out a good correlation to glaucomatous damage.Only PSD and the number of points <1% were correlated to GSSII in FDT. PERG and VEP outcomes were not correlated to glaucatous damage. Conclusion SITA‐SWAP can point out glaucomatous functional damage at least as well as SAP while FDT seems to be less efficient. In perimetric testing the global index PSD seems to be effective in pointing out glaucomatous damage. PERG and VEP are less sensitive but this could be due to the criteria based on VF outcomes to divide examined subjects.
Comparison of FD‐OCT mGCC and pRNFL for the early detection of glaucoma
Authors: ROLLE T , BRIAMONTE C , CURTO D , GRIGNOLO FM 
Published: November 2010

Abstract Purpose To evaluate and compare the Glaucoma detection ability of macular GCC thickness with that of peripapillary RNFL measured by FD‐OCT (RTVue 100. Optovue Inc, CA) in patients with Preperimetric Glaucoma (PPG) and Perimetric Glaucoma (PG) at early stage according to Hodapp‐Parrish‐Anderson classification. Methods 89 patients (178 eyes: 70 PPG, 56 PG and 52 healthy) were enrolled in this cohort study. Each subject underwent complete ophthalmic examination and imaging of mGCC, pRNFL, ONH and 3D disk using RTVue 100. The means of each parameters were compared with ANOVA test. ROC curves were generated for different GCC and RNFL parameters. For both GCC and RNFL protocols the OR‐logical disjunction (Boolean Logic Operator) was calculated. Areas under the ROC curves (AUC) of each parameter were compared ( Delong test). Results The AUCs for Average, Superior, Inferior RNFL were not significantly different (0.72, 0.71, 0.75 respectively): the largest AUC for RNFL parameters was that of RNFL OR (0.79). Average, Superior, Inferior, FLV % GCC (0.74, 0.71, 0.77, 0.76 respectively) were not significantly different from each other and from RNFL AUCs. The largest AUC was that of GLV% GCC (0.81) which is significantly higher than both RNFL and GCC parameters AUCs. Even for the GCC scan, the GCC OR AUC (0.78) was better than others parameters, exception for GLV%. Conclusion We found that GLV% had higher diagnostic accuracy than the simple average for the diagnosis of glaucoma: this must mean that, in some cases, pattern parameters are more sensitive or more specific. The computation of Boolean OR Operator have been found to boost diagnostic accuracy. In summary, analysis of GCC loss pattern further boosted diagnostic accuracy of RNFL measurements.
Logistic regression analysis for early glaucoma diagnosis using optical coherence tomography
Authors: EGEA ESTOPINAN C , PRIETO CALVO E , GUERRI MONCLUS N , FERRERAS AMEZ A , PABLO JULVEZ L , IDOIPE CORTA M 
Published: November 2010

Abstract Purpose To determine and validate the diagnostic ability of a linear discriminant function(LDF) based on the retinal nerve fiber layer thickness at each of the 12 clockhour positions obtained using optical coherence tomography for discriminating between healthy eyes and eyes with early glaucomatous visual field loss Methods We prospectively selected 62 consecutive healthy individuals and 73 patients with open‐angle glaucoma to calculate the LDF. Another independent prospective sample of 280 healthy eyes and 302 glaucomatous eyes was used to evaluate the diagnostic accuracy of the LDF Results The proposed function was LDF=15.584 – (12‐ o’clock segment thickness_0.032) – (7‐o’clock segment thickness_0.041) – (3‐o’clock segment thickness[nasal side]_0.121). The greatest area under the receiver operating characteristic curve was observed for our LDF in both populations: 0.962 and 0.922. Our LDF and the average thickness yielded sensitivities of 74.5% and 67.8%, respectively, at a fixed specificity of 95% Conclusion The LDF increased the diagnostic ability of the isolated retinal nerve fiber layer thickness at the 12 clock‐hour positions. Compared with optical coherence tomography–provided parameters, our LDF had the highest sensitivities at 85% and 95% fixed specificities to discriminate between healthy and early glaucomatous eyes
Comparison of the morphological characteristics of the glaucomatous optic nerve damage in different types of open angle glaucoma
Authors: BOLIVAR G , CASTEJON M , ARRANZ‐MARQUEZ E , AREVALO‐SERRANO J , TEUS MA 
Published: November 2010

Abstract Purpose To analyze the morphological characteristics of the ONH damage in Hyperbaric Glaucoma (HG), Focal damage glaucoma (FG) and in Pseudoexfoliative Glaucoma (PEXG), using Optical Coherence Tomography (OCT). Methods This is a prospective, cross sectional study. Basal, untreated IOP was measured in all cases. ONH and RNFL were evaluated using the OCT stratus 3.0 and the fast optic disc strategy and the fast RNFL thickness, respectively. Only one eye per patient was included. The ANOVA test was used for comparison of the means of quantitative parameters. Results 36 HB, 43 GF and 28 PEXG eyes were included in the study. Untreated IOP was 30.9 mmHg in HB, 19.1 mmHg in FG, and 24.5 mmHg in PEXG eyes. (p=0.0001 for all comparisons). No significant difference was found neither in the RNFL thickness nor in the disc area between groups. In PEXG eyes the rim area and volume were significantly greater than in the other two groups (p=0.0001). No significant difference was observed in the ONH excavation between FG and HB eyes. Conclusion Different types of Open Angle Glaucomas, with a similar degree of RNFL thickness, and similar disc areas, show different morphological ONH damage, as evaluated by the OCT. Automated morphological evaluation of the ONH may be useful to characterize different types of open angle glaucomas.
Correlation between structural and functional damage in three different types of open angle glaucoma
Authors: CASTEJON M , BOLIVAR G , ARRANZ‐MARQUEZ E , AREVALO‐SERRANO J , TEUS MA 
Published: November 2010

Abstract Purpose To analyze the correlation between Optic Nerve Head (ONH) parameters, evaluated using Optical Coherence Tomography (OCT), and visual field damage in newly diagnosed patients with Pseudo Exfoliative Glaucoma (PEXG), Focal Damage Glaucoma (FG) and Hyperbaric Glaucoma (HG). Methods This is a prospective, cross sectional study. Basal, untreated IOP was recorded in all subjects. When both eyes of the same subject fulfilled the inclusion criteria, only one eye was randomly chosen for analysis. OCT stratus 3.0, fast optic disc strategy and Humphrey conventional achromatic perimetry (sita 24‐2) were performed. Linear regression analyses and Pearson’s correlation coefficients between several ONH parameters and the global Visual Field (VF) indices were used for the statistical analysis. Results 36 HB, 43 FG and 28 PEXG eyes were included in the study. We found strong and statistically significant correlations between the MD and the majority of the structural parameters of the ONH in the HB and PEXG groups. No significant correlation was found between any ONH parameter and MD in the FG group. We also found statistically significant correlations between most ONH parameters and the PSD in HB PEXG and FG groups. Conclusion The correlation between morphological visual field damage is different in different type of Open Angle Glaucomas.
Ultrasound biomicroscopic characteristics of the anterior segment in eyes with glaucoma
Authors: KONOPINSKA J , MARIAK Z 
Published: November 2010

Abstract Purpose To evaluate quantitatively changes in anterior chamber depth(ACD),angle width(AW) and intraocular pressure(IOP) induced by phacoemulsification and intraocular lens(IOL)implantation in eyes with glaucoma using ultrasoundbiomicroscopy(UBM). Methods Foreword prospective study of 84 emmetropic eyes from 84 patients divided into two groups.Group I counted 49 eyes with cataract and open‐angle glaucoma(Ia, n=36)and angle‐closure glaucoma(Ib, n=13)underwent phacoemulsification and IOL implantation, group II‐25 control eyes of 25 age‐matched patients scheduled for phacoemulsiﬁcation. 2 control examination were made: before surgery and one month after operation(1).The main diagnostic tests included measuring refraction, aplanation tonometry, pachymetry, gonioscopy, ophthalmoscopy, and anterior chamber depth and angle width using UBM(Vu‐max I, Sonomed). Results In both groups ACD and AW increased significantly after cataract surgery compared to the measurements obtained before surgery(p<0.05),the mean IOP declined in all groups.Group Ia:ACD=2.29±0.4 mm,AW=37.27±10.55°,IOP=17.92±3.76 mmHg; after operation:ACD1=3.68±0.4,AW1=49.64±10.47°,IOP1=15.3±3.1 mmHg; Group Ib: ACD=1.68±0.25 mm,AW=24.38±10.9°,IOP=19.23±6.72mmHg;ACD1=3.65±0.4mm,AW1=45.64±16.04°,IOP1=15.16±5.41mmHg,Group II: ACD=2.97±0.72 mm,AW=38.43±9.43°,IOP=15.2±2.81 mm;ACD1=3.55±0.48 mm,AW1=51.29±8.31°;IOP1=13.2±3.mmHg,(p<0.05) Conclusion After cataract extraction and IOL implantation the width of the angle, and the depth of the anterior chamber increases. This effect is followed by the decrease in IOP in the postoperative period by an average of 2.16 mmHg in open angle glaucoma and 5.11 mmHg in angle closure glaucoma. The project was financed by Ministry of Science and Higher Education, Poland.
Angle configuration changes after phacoemulsification measured with anterior segment optical coherence tomography (AS OCT)
Authors: BRON AM , BIDOT ML , BIDOT S , CREUZOT C 
Published: November 2010

Abstract Purpose To assess the changes of the irio corneal angle configuration and anterior chamber depth with anterior segment optical coherence tomography (AS OCT) after phacoemulsification. Methods Prospective study including consecutive patients operated on age related cataract with phacoemulsification and intraocular lens implantation. An AS OCT was performed before and one month after cataract surgery on the horizontal meridian. The primary objective was to assess the changes of AC depth, iridocorneal angle, angle opening distance at 500 and 750 µm and trabeculum iris space area at 500 and 750 µm. The secondary objective was to evaluate intra ocular pressure (IOP) changes. Results Thirty five eyes of 35 patients were included. Mean age was 72 ± 9 years. Anterior chamber depth increased from 2.62 ± 0.39 µm to 3.66 ± 0.21 µm after cataract removal Nasal AOD 500 and 750 increased by 75 and 73%, nasal TISA 500 and 750 by 69 and 65%, and nasal angle by 52%, respectively, p<0.01. Temporal AOD 500 and 750 increased by 70 and 71%, temporal TISA 500 and 750 by 55 and 64% , and temporal angle by 42%, respectively, p<0.01. A statistically significant but weak correlation was found for AC depth change and axial length, p=0.004, r2=0.22, but not for AC depth change and age and preoperative spherical equivalent, p= 0.52 and p=0.38, respectively. The pre and post operative IOPs were 16.7 ± 3.7 mm Hg and 14.0 ± 2.7 mm, respectively, p=0.0015. Conclusion Cataract extraction leads to important changes of anterior segment configuration evaluated with AS OCT. In our series, all measured parameters showed an opening of the IC angle with wide variation among patients.
An in vivo confocal microscopy study and high frequency ultrasound analysis of filtering bleb functionality
Authors: CARDON A , NOCHEZ Y , BELLICAUD D , PISELLA PJ 
Published: November 2010

Abstract Purpose To evaluate in vivo confocal microscopy (IVCM) analysis and high frequency ultrasounds (US) assessment in the follow‐up of filtering blebs. Methods We retrospectively evaluated 38 filtering blebs (29 patients) which underwent filtering surgery for glaucoma with a mean follow‐up time of 16.4 ± 8.4 months. Examination included IVCM and high frequency US. Filtering blebs were classified in 3 functional clinical groups according to the final intra ocular pressure (IOP): target IOP reached without medication (group 1), target IOP reached with medication (group 2) and target IOP not reached despite medication (group 3). Results Our results showed that failed blebs (group 3) present a low density of microcysts (p=0,0035). Microcysts density was correlated negatively to final IOP (r2=0,23 with p=0,002). We also noticed that eyes with a low microcyst density had been treated with more preserved drops per day prior to the surgery (r²=0,12, p=0,04).This point out the negative influence of preservatives on the conjunctiva creating ocular surface damage and modifying its healing process after filtering surgery. Moreover, IVCM examination did not find any relevant differences between ultrasound groups. In clinically efficient blebs we established a panel of microscopic criteria which could define a higher failure risk group not detected by clinical examination or US imaging. Conclusion IVCM enables a precise imaging of filtering blebs at a microscopic level. It brings a panel of valuable criteria for the detection of microscopic signs associated with failed and fibrosed blebs, or with higher failure risk group.
Choroidal blood flow response to isometric exercise in patients with obstructive sleep apnea syndrome.
Authors: KHAYI H , TONINI M , PEPIN JL , RENARD E , BAGUET JP , ROMANET JP , GEISER MH , CHIQUET C 
Published: November 2010

Abstract Purpose Obstructive sleep apnea syndrome (OSA) has been recently reported to be associated with ischemic and glaucomatous optic neuropathy. The physiopathology of these diseases includes an abnormal regulation in the optic nerve head vasculature. The aim of our study was to characterize the choroidal vascular reactivity to acute increase in ocular perfusion pressure due to exercise in OSA patients. Methods Fourteen newly diagnosed OSA patients were included in this prospective study. Control subjects were matched with OSA patients for body mass index (BMI), gender and age. At the screening visit, each subject underwent a general exam, cardiovascular, neurologic and ophthalmological examinations, and underwent complete overnight polysomnography. The LDF instrument used in this study to measure subfoveal choroidal blood flow (ChBF) measured the following parameters: ChBVel (kHz); volume, ChBVol (in arbitrary units, AU) and the relative flow, ChBF = ChBVel  ChBVol (in AU). Vascular choroidal reactivity was tested during squatting. Results OSA patients exhibited a similar choroidal reactivity during increase in OPP (i.e. stability of choroidal blood flow) than controls until an increase of OPP about 145%. We found a similar vascular resistance increase in both groups during increase of OPP. Conclusion This prospective comparative study explored for the first time the choroidal blood flow of OSA patients and showed that subfoveal ChBF reactivity to gas in OSA patients differed from that of healthy control subjects. These preliminary results suggest that choroidal vasculature of OSA patients remained vasoconstricted when OPP increased, due to a chronic sympathetic activation.
Retinal detachment after pneumatic trabeculoplasty:case report
Authors: PESCE G , MACINAGROSSA G , CANTATORE A , DE BELLIS A , MONTRONE L , DI GESU I , MONTRONE F 
Published: November 2010

Abstract Purpose The authors report on a case of retinal detachment arising after treatment for ocular hypertension with pneumatic trabeculoplasty. Methods Patient male,39 years old,previous surgery with excimer laser for correcting myopia in both eyes.The patient had various treatments of pneumatic trabeculoplasty;he came two days after to our attention with the presence of retinal detachment and retinal hole in left eye. The patient underwent surgery in encircling and sealing the break with ab external technique. Results The postoperative course was smooth with reattachment of the retina and good recovery of vision in left eye. Conclusion The pneumatic trabeculoplasty is a simple and safe procedure for treatment of patients with primary open angle glaucoma (POAG) or ocular hypertension (OH).Controindications are:monocular patients with <1 / 10 visual acuity in the other eye, patients with other ocular diseases or previous surgical procedures, diabetes. The results suggest that pneumatic trabeculoplasty was absolutely contraindicated in this patient.