bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediksi Inflasi, Tingkat Suku Bunga, dan Nilai Ekspor dengan Vector Autoregressive dan Estimator Deret Fourier Simultan
Authors: Lu'lu'a Na'imatul , Haq Affan Fayzul , Fitri Marfa Audilla , Mardianto M. Fariz Fadillah , Pusporani Elly 
Published: May 2024

In the face of global economic uncertainty, predictions of the value of inflation, interest rates, and the value of exports are becoming increasingly crucial. This is also closely related to the SDGs in goals 8 and 9, namely on Decent Work and Economic Growth as well as Industry, Innovation, and Infrastructure. This study discusses the use of Vector Autoregressive (VAR) methods and Fourier series estimators to improve the accuracy of predictions of these economic variables. The data used are the inflation, export value, and BI Rate sourced from Bank Indonesia and Badan Pusat Statistik with a monthly period and starting from the beginning of 2010 to September 2023. After analysis, the best method was obtained, namely the Fourier series estimator which included cosine and sine components with oscillation parameters 6 with MAPE 1.51% on the inflation value, 1.65% on the interest rate, and 3.03% on the export value. By considering the interaction between economic variables, the prediction results are expected to provide deeper understanding, support decision-making at the macroeconomic level, and assist governments, central banks, and market participants in identifying risks and planning export strategies.
The use of isolated peripheral lymphocytes and human whole blood in the comet assay
Authors: Najafzadeh Mojgan , Anderson Diana 
Published: May 2024

Abstract

The Comet assay, a highly sensitive method for detecting DNA damage, is used to measure DNA breaks and alkali-labile lesions in eukaryotic cells. This study outlines the application of whole blood in the alkaline gel electrophoresis method. A total of 1,200 blood samples from various individuals were analysed, comprising 300 samples from healthy individuals, 300 from suspected or pre-cancerous individuals, and 600 from cancer patients. Each sample was divided into two identical volumes in separate falcon tubes. The blood samples were prepared and preserved by adding an equal amount of RPMI medium and 10% DMSO. Analysis of the data using Student’s t-Test revealed a p-value of 0.59 for Olive tail moment (OTM) and 0.16 for % tail DNA, indicating no statistically significant differences between the two methods, whether with or without treatment. In conclusion, employing whole blood instead of isolated lymphocytes not only saves time but also maintains a high level of sensitivity, requiring less than 20 µL of blood from each individual.
Geographical Differences in Ophthalmic Trauma Outcomes and Risk Factors: The International Globe and Adnexal Trauma Epidemiological Eye Study (IGATES)
Authors: Hoskin Annette , Ng Sean Ming Sheng , Blanch Richard , Giridhar Anantharaman , Pauly Mariam , Shah Mehul , Sen Alok , Irawati Yunia , Pradhan Eli , Romero Jose , Agarwal Manisha , Soleimani Mohammad , Grover Ashok , Mishra Chitaranjan , Ocampo Hugo , Khatri Anadi , Bhalerao Sushank , Bhasin Purendra , Ayachit Apoorva , Subramanian Prem , Khandelwal Rekha , Natarajan Sundaram , Sindal Manavi , Singh Shakeen , Fredrick Nirmal , Zvorničanin Jasmin , Sundar Gangadhara , Dalma José , Awan Muhammad Amer , Ratra Dhanashree , Bhattacharjee Kasturi , Choovuthayakorn Janejit , Sharma Samata , Tawdekar Yogesh , Jayadev Chaitra , Boesoirie Shanti , Rousselot Andres , Rojas-Carabali William , Watson Stephanie , Lee Bernett , Agrawal Rupesh 
Published: May 2024

Abstract

Objectives: characterize the international variation in ophthalmic trauma and validate prognostic markers for low-, middle- and high income countries.
Subjects/Methods:.Observational Multicentre cohort study using International Globe and Adnexal Trauma Epidemiological Eye Study (IGATES) to collect data on acute presentations with ophthalmic injury including open/closed globe injury, and/or Adnexal/orbital involvement, and/or Intraocular/ Intraorbital foreign body from April 2014 to August 2023. 5350 patients (5557 eyes) from 31 centers in 12 countries. Main outcome measures included demographics, mechanism and setting of injury, and presenting and final visual outcomes.
Results: Male to female ratio of 3.6:1 and mean age 30.7 years-old (range 0.1 to 103 years-old, standard deviation 18.5). Age, gender, presenting and final best corrected visual acuity were strongly associated with country (p<0.005). Poor final visual outcomes were strongly associated with Ocular Trauma Score (p<0.005) and type of injury (p<0.005). Median BCVA LogMAR of open globe injuries (1 LogMAR) compared to closed globe injuries (0.2 LogMAR). Duration between injury and presentation and improvement in BCVA LogMAR were strongly associated with countries income classification with high-income countries (HIC) showing reduced duration to presentation (HIC 5 hours, LIC 28 hours) and increased improvement (-0.40 HIC, -0.19 LIC) when compared to low income countries (LIC’s).
Conclusion: Country of injury, ocular trauma score and age were associated with presenting and final visual outcomes. IGATES provides an opportunity to collect global data on ophthalmic trauma to facilitate management and prevention strategies aimed towards improving outcomes.
Development of a Simple, Low-Cost, Highly Specific Colorimetry-Based Whole-Cell Bacterial Biosensor for Cadmium Detection in the Environment
Authors: Prabhakaran Rajkumar , Tharmarajan Ramprasath , Karuppiah Prakash Shyam , Sadasivam Selvam Govindan 
Published: May 2024

Abstract

The urgent requirement for cost-effective technology to detect heavy metals in the environment is undeniable. This study introduces a novel approach: a low-cost colorimetry-based optical whole-cell bacterial biosensor utilizing a newly identified reporter gene, agarase (dagA), for the specific detection of cadmium (Cd). Through the incorporation of a Cd-sensing promoter (PcadR) upstream of agarase in Pseudomonas aeruginosa, a highly specific Cd biosensor was engineered. Initially developed in E. coli and subsequently in P. aeruginosa, these agarase (dagA) based optical whole-cell bacterial biosensors exhibited promising capabilities. Specifically, P. aeruginosa carrying the vector PcadR-dagA demonstrated a strong linear range detection for cadmium chloride concentrations ranging from 10 ppb to 500 ppm (R2 = 0.9851), with a correlation of 0.96 (Bland-Altman) to the standard inductively coupled plasma mass spectroscopy method. Furthermore, morphological alterations were observed through scanning electron microscopy. Notably, this colorimetry-based optical whole-cell bacterial biosensor presents itself as a straightforward, resilient, portable, and cost-effective solution, eliminating the need for complex sample preparation. Consequently, the biosensor platform proposed in this study stands as a viable, low-cost alternative for monitoring low levels of Cd in the environment.
The shy, the digger and the adventurous: consistency and repeatability of personality traits in the social Lusitanian pine vole, Microtus lusitanicus
Authors: Andrade Rita S. , von Merten Sophie , Varela Susana A. M. , Mathias Maria da Luz , Cerveira Ana Mota 
Published: May 2024

Abstract

In social species, the array of behavioral traits displayed by the different elements of the group can play a key role in the dynamics and fitness of the colony. This could help explain group organization, dispersion, and species’ sociality level. The Lusitanian pine vole, with its complex tunnel system and cooperative breeding strategy, is a perfect candidate to study personality in a social species. We formed laboratory-colonies with wild-caught individuals and their laboratory-reared offspring, and performed repeated behavioral tests of activity, exploration, and boldness. We identified one personality trait (Shyness) and two behavioral syndromes: the Active-Explorative-Bold Syndrome, characterizing individuals that are active, explorative, and bold aboveground; and the Explorative-Shy Syndrome, characterizing individuals not bold enough to venture out in the open often, but being quite explorative underground. Our results suggest that some individuals spend more time aboveground to forage for food and nest materials, while others may be more prone to stay underground, maintaining the burrows and taking care of offspring. By testing across different generations, we found that some traits were not consistent across life stages, indicating that behavioral changes occur during M. lusitanicus’ ontogeny. Lastly, we also found differences between wild-caught and lab-reared individuals, suggesting that captivity can lead to a loss of variation in personality traits in this species. Our results can contribute to a better understanding of the role of diverse personality types in populations of social species, of how personality structure can change across the lifespan and how environmental complexity can shape personality traits.
Bilateral severe Tolosa-Hunt syndrome in an elderly Filipino female: A case report
Authors: Pr Mario Jr Bugay , Apostol-Alday Angela , Adiao Karen Joy 
Published: May 2024

Abstract

Background
Only 1–2 per 1,000,000 individuals are diagnosed with Tolosa Hunt Syndrome (THS). While most will present with unilateral symptoms, 4.6% have bilateral involvement, often affecting cranial nerves III, IV and VI incompletely.[2] Only 2 papers published cases with simultaneous and complete ophthalmoplegia and ptosis, both resolved either spontaneously or with high dose steroids. This case highlights a THS case with bilateral complete cavernous sinus syndrome initially on the right, followed several months later on the left.
Case Report:
Here we report a 78 years old female who was diagnosed with right sided then followed 3 months later by left sided THS while on low to moderate dose of steroids. She had bilateral painful ophthalmoplegia, hyperesthesia on the ophthalmic and maxillary branches of cranial nerve V and absent direct and consensual pupillary eye reflexes. She had prolonged bilateral R1, R2 and R2’ on blink reflex confirming affection of CN V, and enhancement on the right parasellar area on contrast-enhanced cranial CT indicating presence of granulation tissue.
Conclusion
THS should be considered in a patient presenting with bilateral painful ophthalmoplegia whether this happens simultaneously or in succession. Pulse therapy or high dose oral steroid is recommended as initial treatment for THS unless there are contraindications.
Is 70 the new 60? A longitudinal analysis of cohort trends in intrinsic capacity in England and China
Authors: Beard John , Katja Hanewald , Si Yafei , Thiyagarajan Jotheeswaran , Moreno-Agostino Dario 
Published: May 2024

Abstract

To understand how the health of older adults today compares to that of previous generations, we estimated intrinsic capacity and subdomains of cognitive, locomotor, sensory, psychological and vitality capacities in participants of the English Longitudinal Study on Ageing (ELSA) and the China Health and Retirement Longitudinal Study (CHARLS). We applied multilevel growth curve models to examine change over time and cohort trends. We found that more recent cohorts entered older ages with higher levels of capacity, and their subsequent age-related declines were somewhat compressed compared to earlier cohorts. These improvements in capacity were large, with the greatest gains being in the most recent cohorts. For example, a 68-year-old ELSA participant born in 1950 had higher capacity than a 62-year-old born just 10 years earlier. Trends were similar for men and women, and findings were generally consistent across English and Chinese cohorts.
Application of continuous intraoperative neuromonitoring in the study of spinal nerve root thermal injury in a porcine model
Authors: Wang Chengxia , Li Zhuofu , Jiang Shuai , Zhong Woquan , Li Weishi 
Published: May 2024

Abstract

Background
A warning system to avoid potential nerve root thermal injury caused by automatic spine robot is essential. However, there is a lack of basic research to support the development of such warning system. The aims of this study are to confirm the feasibility of continuous intraoperative neuromonitoring (CIONM) in spinal nerve root monitoring and study the exposure time of spinal nerve root thermal injury at different temperature in a porcine model.
Methods
The experiment was carried out on 32 nerve roots of 4 pigs (bilateral L4-S1 nerve roots). Sham group (CIONM only), control group (Room temperature stimulation with CIONM), and 40°C, 45°C, 50°C, 55°C, 60°C, 65°C temperature stimulation groups were conducted at random in each pig. The change of EMG was recorded continuously. The exposure time of nerve root injury at different temperatures was recorded. Histological analysis of the nerve roots was performed to confirm the injury.
Results
The EMG of the sham, control, 40°C and 45°C groups were stable during the experiment, and no significant nerve root injury was observed on histological analysis. The time of 50% EMG amplitude decrease in 50℃, 55℃, 60℃ and 65℃ groups were 277.5 ± 18.2, 59.5 ± 6.2, 20.8 ± 1.0 and 16.5 ± 1.3 seconds, respectively. And the nerve specimens of these groups showed varying degrees of damage.
Conclusions
CIONM can be used for continuous monitoring of spinal nerve roots. For 5 minutes, 40℃ and 45℃ did not cause significant nerve root injury. However, when the temperature reached 50℃ and above, nerve roots appeared injury.
Diagnostic Value of Systemic Immune Inflammation Index in Acute Appendicitis and Complicated Appendicitis in Pregnant Patients
Authors: ALTUG Ertugrul , Kilavuz Huseyin , Çakir Adem , Sener Kemal , Guven Ramazan , Korkut Semih 
Published: May 2024

Abstract

Introduction:Acute pain in the right lower quadrant during pregnancy is difficult to approach and acute appendicitis must be excluded. The complication rate in pregnant acute appendicitis increases as a result of delayed diagnosis due to physiological and anatomic changes. The systemic immune inflammatory index (SII), which includes several inflammatory tests, is considered to be a good indicator of acute inflammation. The aim of the present study was to investigate the diagnostic value of SII in the diagnosis of acute appendicitis and complicated appendicitis in pregnant women.Material-Method:This retrospective, single-center study was designed. This study was performed in pregnant women over 12 weeks of gestation who were diagnosed with acute appendicitis as indicated by pathology report and met the inclusion criteria. Vital parameters, demographic characteristics, laboratory values, presence of complicated appendicitis, and pathology reports were taken into analysis.Results:The present study was performed with 76 pregnant women, including 38 pregnant women with acute appendicitis and 38 pregnant women with healthy controls. SII had a sensitivity of 68.4% and specificity of 81.6% with a cut-off value of 1330.66 in pregnant acute appendicitis cases (AUC: 0.790; 95% CI: 0.686–0.984; p < 0.001) and SII level was significantly higher in complicated appendicitis cases with a sensitivity and specificity of 66.7% and 91.3%, respectively, with a cut-off value of 2301.66 (AUC: 0.812; 95% CI: 0.665–0.958; p = 0.001).Conclusion:SII is a cost-effective, rapid, easily calculated, and powerful marker that can be used for the diagnosis of both acute and complicated appendicitis in pregnant patients.
MOG-specific CAR Tregs: a novel approach to treat multiple sclerosis
Authors: Frikeche Jihane , David Marion , Mouska Xavier , Treguer Damien , Cui Yue , Rouquier Sandrine , Lecorgne Enora , Proics Emma , Fall Papa Babacar , Lafon Audrey , Lara Gregory , Menardi Alexandra , Fenard David , Abel Tobias , Gertner-Dardenne Julie , Rosa Maurus , Dumont Céline , Dumont Céline 
Published: May 2024

Abstract

Multiple sclerosis (MS) is an autoimmune disease affecting the central nervous system (CNS) with the immune system attacking myelin sheaths leading to neuronal death. While several disease-modifying therapies are available to treat MS, these therapies are not universally effective and do not stop disease progression. More personalized long-term treatment options that target specific aspects of the disease, such as reducing relapse frequency, delaying disability accumulation, and addressing symptoms that impact daily functioning, as well as therapies that can promote neuroprotection and repair are needed. Chimeric Antigen Receptor (CAR) T cell therapies have revolutionized cancer treatment by intravenously (IV) administering a defined dose of T cells with high specificity provided by the CAR. An autologous CAR-T cell therapy using suppressive regulatory T cells (Tregs) inducing long-lasting tolerance would be the ideal treatment for patients. Hence, we expanded the application of CAR-T cells by introducing a CAR into Tregs to treat MS patients. We developed a myelin oligodendrocyte glycoprotein (MOG)-specific CAR-Treg cell therapy for patients with MS. MOG is expressed on the outer membrane of the myelin sheath, the insulating layer the forms around nerves, making it an ideal target for CAR-Treg therapy. Our lead candidate is a 2nd generation CAR, composed of an anti-MOG scFv screened from a large human library. In vitro, we demonstrated CAR-dependent functionality and showed efficacy in vivo using a passive EAE mouse model. Additionally, the MOG-CAR-Tregs have very low tonic signaling with a desirable signal-to-noise ratio resulting in a highly potent CAR. In summary our data suggest that MOG-CAR-Tregs are a promising MS treatment option with the potential to induce long-lasting tolerance in patients.
The prevalence and factors of work-related fatigue among nurses: a meta-analysis and systematic review
Authors: Pi Rong , Liu Yunfang , De Zong , Wan Yali , Chen Yi , He Zihan , Li Wenjing , Hou Zixuan , Yan Rong , Wang Yan , Li Suyun 
Published: May 2024

Abstract

Background
Numerous studies have evaluated the level of work-related fatigue in nurses and its risk factors. However, none of these studies have rigorously assessed these through meta-analysis and systematic review.
Objectives
This study aimed to examine work-related fatigue among nurses and identify the factors that influence it.
Method
The review searched eight databases, including PubMed, Web of Science, Scopus, CINAHL, PsycINFO, and Chinese databases such as China National Knowledge Infrastructure (CNKI), Chinese Biological Medical (CBM), and WanFang Database. The temporal scope of the search encompasses a temporal interval commencing from inception and extending to October 2023. The PRISMA guideline was used to report the meta-analysis and systematic review. The research team conducted a comprehensive study of selection, quality assessments, data extraction and analysis of all included literature. The means and standard deviations of three subscales of work-related fatigue were pooled using random effects meta-analysis using Stata 18.0 software. The registration PROSPERO number is CRD42023456337.
Results
A total of 3259 initial studies were retrieved, of which 48 qualified articles were finally included in this article. The pooled mean scores of acute fatigue(AF), chronic fatigue(CF) and inter-shift recovery(IR) was 62.99(95% CI: 59.38–66.4), 51.30(95% CI: 46.82–55.78) and 49.15(95% CI: 43.92–54.37). Furthermore, the factors influencing nurses’ work-related fatigue included both organizational and individual variables.
Conclusion
Clinical nurses were at a moderately high level of acute and chronic fatigue. Four themes were summarized as factors influencing the level of work-related fatigue among nurses, including organizational culture, Management system, individual capability and individual acts. Consequently, Nurse’ work-related fatigue is a vital global issue that roots in multiple causes, and more resources should be used to improve current situation.
Primary antibiotic prophylaxis in biliary atresia did not result in decreased infection rate: a multi-center retrospective study
Authors: Brody Yael , Slae Mordechai , Amir Achiya Z. , Mozer-Glassberg Yael , Bar-Lev Michal , Shteyer Eyal , Waisbourd-Zinman Orith 
Published: May 2024

Abstract

Background and objectives: For infants with biliary atresia (BA), solid research is lacking regarding the effectiveness of prophylactic antibiotics for preventing ascending cholangitis post-Kasai portoenterostomy (KPE), and the effectiveness of primary endoscopic screening for varices. We conducted a retrospective study of patients treated in four tertiary centers in Israel during 2008-2018.
Methods: We collected clinical and laboratory data of 72 children, from their diagnosis with BA until liver transplantation (LT) or the study's end.
Results: The median age at KPE was 58.5 days. Twenty-three (32%) patients had a successful KPE. The incidence of ascending cholangitis was similar among patients with successful and failed KPE: 6/23 (26%) and 15/45 (33%), respectively. Among the 35 (49%) patients treated with primary antibiotic prophylaxis, compared to those not treated, cholangitis episodes occurred earlier (after a median 77 vs. 239 days, p=0.016). Of the 72 patients, 28% underwent upper endoscopy for varices screening at median age of 5.5 years; this revealed normal findings in 45%, grade I varices in 35%, and grade II varices in 20%. A total of 28 patients (39%) underwent LT during the study follow-up. Survival with native liver (SNL) was 54% at 5 years.
Conclusion: Primary antibiotic prophylaxis did not appear to reduce ascending cholangitis episodes in our cohort. Endoscopic screening showed predominantly findings that did not warrant intervention. Further research is needed to establish evidence-based practices for the effective management of infants with BA.
Quantum Tunneling Noise-based Entropy Core for True Random Number Generation
Authors: Kadam Abhishek , Hajare Hemant , Singh Ajay , Somappa Laxmeesha , Baghini Maryam Shojaei , Ganguly Udayan 
Published: May 2024

Abstract

Securing edge devices is crucial in today’s interconnected world, where the Internet of Things (IoT) is rapidly expanding. A “True Random Number Generator (TRNG)” is pivotal in ensuring the security of edge devices. However, strict area and power constraints are key requirements in edge applications. A high entropy source to facilitate an energy-efficient TRNG without adding extra area overhead is critical in safeguarding sensitive data and ensuring the integrity of edge computing environments. We propose a novel, experimentally validated, low area and low power entropy source that leverages inherent natural stochasticity in quantum tunneling current. In comparison with state-of-the-art TRNG architectures implemented in commercially available technologies, our innovative Quantum Tunneling-driven Ring Oscillator (QTRO) enables the TRNG with the lowest energy consumption of only 0.16 pJ/bit while also occupying the least area of only 81 μm2 in GF45RFSOI technology. The area and energy efficiency stem from quaint quantum nature – yet implemented on a mature VLSI technology. Our design is validated using NIST SP800-22 and SP800-90B randomness tests without the need to post-process the generated bitstream. We also validated our design against process, voltage, and temperature (PVT) variations, which shows
resilience against potential security attacks.