bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid growth produces transient cortical weakness: A risk factor for metaphyseal fractures during puberty
Authors: Wang Qingju , Wang Xiao-Fang , Iuliano-Burns Sandra , Ghasem-Zadeh Ali , Zebaze Roger , Seeman Ego 
Published: January 2010

Abstract
Fractures of the distal radius in children have a similar incidence to that found in postmenopausal women but occur more commonly in boys than in girls. Fractures of the distal tibia are uncommon in children and show no sex specificity. About 90% of lengthening of the radius but only 30% of lengthening of the tibia during puberty occur at the distal growth plate. We speculated that more rapid modeling at the distal radial metaphysis results in a greater dissociation between growth and mineral accrual than observed at the distal tibia. We measured the macro- and microarchitecture of the distal radial and tibial metaphysis using high-resolution peripheral quantitative computed tomography in a cross-sectional study of 69 healthy boys and 60 healthy girls aged from 5 to 18 years. Bone diameters were larger but total volumetric bone mineral density (vBMD) was lower at the distal radius (not at the distal tibia) by 20% in boys and by 15% in girls at Tanner stage III than in children of the same sex at Tanner stage I (both p &lt; .05). In boys at Tanner stage III, total vBMD was lower because the larger radial total cross-sectional area (CSA) had a thinner cortex with lower vBMD than in boys at Tanner stage I. In girls at Tanner stage III, the larger total radial CSA was not associated with a difference in cortical thickness or cortical vBMD relative to girls in Tanner stage I. Cortical thickness and density at both sites in both sexes after Tanner stage III were greater than in younger children. Trabecular bone volume fraction (BV/TV) was higher in boys than in girls at both sites and more so after puberty because trabeculae were thicker in more mature boys but not in girls. There was no sex- or age-related differences in trabecular number at either site. We infer that longitudinal growth outpaces mineral accrual in both sexes at the distal radius, where bone grows rapidly. The dissociation produces transitory low cortical thickness and vBMD in boys but not in girls. These structural features in part may account for the site and sex specificity of metaphyseal fractures during growth. © 2010 American Society for Bone and Mineral Research
Effect of vitamin D3 and calcium on fracture risk in 65- to 71-year-old women: A population-based 3-year randomized, controlled trial—the OSTPRE-FPS
Authors: Salovaara Kari , Tuppurainen Marjo , Kärkkäinen Matti , Rikkonen Toni , Sandini Lorenzo , Sirola Joonas , Honkanen Risto , Alhava Esko , Kröger Heikki 
Published: January 2010

Abstract
Antifracture efficacy of high-dose vitamin D (800 IU) and calcium (1000 mg) remains controversial. To determine whether daily 800 IU of vitamin D and 1000 mg of calcium supplementation prevents fractures, we randomized 3432 women of the population-based Osteoporosis Risk Factor and Prevention (OSTPRE) Study cohort (ages 65 to 71 years) living in the region of northern Savonia, Finland (latitude 62° to 64°N) for 3 years to receive 800 IU of cholecalciferol and 1000 mg of calcium as calcium carbonate or to a control group that did not receive placebo. The main outcome measure was incident fractures. Fracture data were collected in telephone interviews and validated. Data on 3195 women, 1586 in the intervention group and 1609 in the control group, were available for analysis. In adjusted Cox proportional hazards models, the risk of any fracture decreased in the vitamin D and calcium group by 17% [adjusted hazard ratio (aHR) = 0.83; 95% confidence interval (CI) 0.61–1.12], and the risk of any nonvertebral fracture decreased by 13% (aHR = 0.87; 95% CI 0.63–1.19). The risk of distal forearm fractures decreased by 30% (aHR = 0.70; 95% CI 0.41–1.20), and the risk of any upper extremity fractures decreased by 25% (aHR = 0.75; 95% CI 0.49–1.16), whereas the risk of lower extremity fractures remained essentially equal (aHR = 1.02; 95% CI 0.58–1.80). None of these effects reached statistical significance. In conclusion, this study did not produce statistically significant evidence that vitamin D and calcium supplementation prevents fractures in a 65- to 71-year-old general population of postmenopausal women. © 2010 American Society for Bone and Mineral Research. © 2010 American Society for Bone and Mineral Research
Hypercalcemia and soft tissue calcification owing to sarcoidosis: The sunlight-cola connection
Authors: Demetriou Emily TW , Pietras Sara M , Holick Michael F 
Published: January 2010

Abstract
Hypercalcemia occurs in sarcoidosis because of 1,25-dihydroxyvitamin D production by pulmonary alveolar macrophages. Long-standing hypercalcemia and hypercalciuria may cause such complications as nephrocalcinosis, nephrolithiasis, and soft tissue calcification, which can be at least partially reversible with treatment. Here we present a 43-year-old African-American man with diffuse soft tissue calcifications and acute kidney injury owing to sarcoidosis-induced hypercalcemia, probably exacerbated by sun exposure and phosphorus intake in the form of dietary cola drinks. Soft tissue calcifications resolved and kidney function improved significantly with hydration and glucocorticoid therapy. We discuss the pathophysiology of the hypercalcemia of sarcoidosis and current treatment options. © 2010 American Society for Bone and Mineral Research
IgGs containing light chains of the λ and κ type and of all subclasses (IgG1‐IgG4) from sera of patients with multiple sclerosis hydrolyze DNA
Authors: Parkhomenko Taisiya A. , Legostaeva Galina A. , Doronin Boris M. , Buneva Valentina N. , Nevinsky Georgy A. 
Published: January 2010

AbstractWe present the first evidence demonstrating that small fractions of IgGs of all four subclasses (IgG1–IgG4) are catalytically active in the hydrolysis of DNA and on average their relative activity (nM supercoiled DNA/1mg IgG/1 h) increases in the order: IgG1 (0.58) < IgG2 (0.94) < IgG3 (1.4) < IgG4 (4.1), while their approximate relative contribution to the total activity of abzymes increases in the order: IgG1 (6.9%) < IgG3 (9.3%) < IgG2 (18.2%) < IgG4 (65.6%). On average IgGs containing light chains of the λ‐type are severalfold more active in the hydrolysis of DNA than IgGs with light chains of the κ‐type. Using different physicochemical methods of antibody analysis we have shown that the immune system of multiple sclerosis patients generates a variety of anti‐DNA abzymes of different type and with different catalytic properties, which can play an important role in multiple sclerosis pathogenesis. Copyright © 2010 John Wiley & Sons, Ltd.
Radiotherapy and extent of surgical resection in retroperitoneal soft‐tissue sarcoma: Multi‐institutional analysis of 261 patients
Authors: Sampath Sagus , Hitchcock Ying J. , Shrieve Dennis C. , Randall R. Lor , Schultheiss Timothy E. , Wong Jeffrey Y.C. 
Published: January 2010

AbstractBackground and ObjectiveTo examine the impact of adjuvant radiotherapy (RT) and surgical technique on survival in retroperitoneal soft‐tissue sarcoma.MethodsA retrospective analysis was conducted using the National Oncology Database, a proprietary database of aggregated tumor registries owned by IMPAC® Medical Systems (Sunnyvale, CA). Patients who received definitive surgery with negative or microscopic‐positive margins were included. Multivariate analysis was performed using the Cox proportional hazards model. Survival curves were estimated by the Kaplan–Meier method and were compared for statistical significance (P < 0.05) using the log‐rank test.ResultsTwo hundred sixty‐one patients met inclusion criteria. The median follow‐up was 59 months (range 0.2–186 months). The 5‐year cause‐specific survival (CSS) and local failure‐free survival (LFFS) were 73% and 66%, respectively. Grade, margin status, and histology were independent predictors for CSS (P < 0.05). Adjuvant RT was associated with a significant improvement in LFFS over surgery alone (hazard ratio = 0.42, 95% confidence interval 0.21–0.86,P < 0.05). Patients receiving simple excision and RT had a 5‐year LFFS of 88%, significantly higher than wide resection with or without RT (log‐rank,P < 0.05).ConclusionAdjuvant RT is associated with a lower risk of local relapse compared to surgery alone. The impact of surgical technique on adjuvant RT efficacy warrants further study. J. Surg. Oncol. 2010; 101:345–350. © 2010 Wiley‐Liss, Inc.
Loss of E‐cadherin and β‐catenin is correlated with poor prognosis of ampullary neoplasms
Authors: Hsu Hui‐Ping , Shan Yan‐Shen , Jin Ying‐Tai , Lai Ming‐Derg , Lin Pin‐Wen 
Published: January 2010

AbstractBackground and ObjectivesDistant metastasis resulting from carcinoma cell detachment from the primary tumor involves modification of adhesion molecules. This study was conducted to examine the correlation of E‐cadherin/β‐catenin expression with survival and recurrence in ampullary neoplasms.MethodsPatients with diagnoses of ampullary neoplasms were enrolled in the study. Demographics, operative findings, and histopathological data were collected by retrospective chart review. Expression of E‐cadherin and β‐catenin were detected by immunohistochemistry.ResultsA total of 110 patients were enrolled in the study. Preservation of membranous staining of E‐cadherin was noted in 41 (37%) patients, aberrant cytoplasmic staining in 48 (44%) patients, and complete loss in 21 (19%) patients. Loss of E‐cadherin was associated with pancreatic invasion, recurrence, and poor prognosis. Membranous staining of β‐catenin was noted in 65 (59%) patients, cytoplasmic or nuclear accumulation in 16 (15%) patients, and complete loss in 29 (26%) patients. Loss of β‐catenin expression was associated with tumor markers, ulcerative type, liver metastases, and poor prognosis. Pancreatic invasion, lymph node involvement, and loss of β‐catenin expression were predictors of disease recurrence.ConclusionsLoss of the E‐cadherin/β‐catenin complex is related to poor prognosis in ampullary cancer. Loss of β‐catenin is predictor of recurrence in multivariate analysis. J. Surg. Oncol. 2010; 101:356–362. © 2010 Wiley‐Liss, Inc.
Intraoperative sentinel lymph node detection by vital dye through laparoscopy or laparotomy in early endometrial cancer
Authors: Mais Valerio , Peiretti Michele , Gargiulo Tigellio , Parodo Giuseppina , Cirronis Maria Giuseppina , Melis Gian Benedetto 
Published: January 2010

AbstractBackground and ObjectivesRecent studies reported the feasibility of intraoperative lymphatic mapping in women with endometrial cancer but none of these studies compared the sentinel lymph nodes (SLNs) detection rates obtainable through laparoscopy or laparotomy. The purpose of this study was to address this issue.MethodsThirty‐four patients with clinical stage I–II endometrial cancer were enrolled in this prospective comparative trial. Four milliliters of Patent Blue Violet were injected into the cervix after the induction of general anesthesia. The assessment of SLNs was done in 17 patients through laparoscopy and in 17 patients through laparotomy as first step of systematic pelvic lymphadenectomy. Both SLNs and non‐SLNs were evaluated for micrometastases.ResultsThe SLNs detection rate was significantly higher (82%) for laparoscopy than for laparotomy (41%; P = 0.008). Pelvic lymph node metastases were present in 6 out of 34 patients (18%) but only 3 (50%) of these patients were correctly identified.ConclusionsSLNs detection rate is significantly higher through laparoscopy than through laparotomy after vital dye pericervical injection but intraoperative vital dye pericervical injection is not reliable as part of standard care for predicting lymphatic spread in women with early stage endometrial cancer. J. Surg. Oncol. 2010; 101:408–412. © 2010 Wiley‐Liss, Inc.
Propagation and Termination Kinetics of PEGylated Methacrylate Radical Polymerizations
Authors: Siegmann Rebekka , Jeličić Aleksandra , Beuermann Sabine 
Published: January 2010

AbstractPropagation and chain‐length averaged termination rate coefficients, kp and <kt>, for radical polymerizations of methacrylates carrying poly(ethylene glycol) (PEG) units are reported. kp derived from pulsed laser initiated polymerizations in bulk, in organic solvents, and in ionic liquids follows the methacrylate‐type family behavior. Contrary, diffusion controlled kt values obtained from chemically initiated polymerizations with in‐line FT‐NIR monitoring of monomer conversion are strongly affected by the PEG units in the ester group. Compared to alkyl methacrylates <kt> is unexpectedly high. Moreover, <kt> of poly(ethylene glycol) ethyl ether methacrylate shows a significant reduction in kt already at 15% conversion, whereas dodecyl methacrylate <kt> is constant up to at least 70% conversion.magnified image
Trace formulas and a Borg‐type theorem for CMV operators with matrix‐valued coefficients
Authors: Zinchenko Maxim 
Published: January 2010

AbstractWe prove a general Borg‐type inverse spectral result for a reflectionless unitary CMV operator (CMV for Cantero, Moral, and Velázquez [13]) associated with matrix‐valued Verblunsky coefficients. More precisely, we find an explicit formula for the Verblunsky coefficients of a reflectionless CMV matrix whose spectrum consists of a connected arc on the unit circle. This extends a recent result [39] for CMV operators with scalar‐valued coefficients.In the course of deriving the Borg‐type result we also use exponential Herglotz representations of Caratheodory matrix‐valued functions to prove an infinite sequence of trace formulas connected with CMV operators (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
p ‐nuclear operators in the sense of Grothendieck
Authors: Hinrichs Aicke , Pietsch Albrecht 
Published: January 2010

AbstractThe by now classical theory of p ‐nuclear operators with 0 < p ≤ 1 was founded in Grothendieck's thesis (1953). Since that time only little progress has been achieved. This article describes the present state of the art. We improve Grothendieck's multiplication theorem, characterize the p ‐integral operators, and give a long list of challenging open problems. The abstract theory is illustrated by considering the identity map and the discrete Fourier transform from lan onto lbn with 1 ≤ a, b ≤ ∞ (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
The impact of presentation vs. interaction design on user satisfaction with digital libraries
Authors: Liu Jingjing , Zhang Xiangmin 
Published: January 2010

AbstractInterface design includes two aspects: interaction design and presentation design, but there have not been many works examining the effect of these two aspects on user satisfaction with the system. We conducted a comparison study analyzing user satisfaction with system features in three digital libraries: ACM Digital Library, IEEE Xplore Digital Library, and IEEE Computer Society Digital Library. Our results showed that the two interface aspects of a system: the presentation and interaction designs, may receive rather different, even opposite (positive or negative) user opinions. Weak design of the interaction aspect could possibly be compensated by a good design in interface presentation. We observed that interface presentation is no less important than the interaction aspect. Based on the findings, we suggest interface design balancing between these two aspects instead of emphasizing either one but ignoring the other.
Author name disambiguation for collaboration network analysis and visualization
Authors: Strotmann Andreas , Zhao Dangzhi , Bubela Tania 
Published: January 2010

AbstractIn this paper we outline a heuristic algorithm for disambiguating author names of publications via deterministic clustering based on well‐defined similarity measures between publications in which their names appear as authors. The algorithm is designed to be used in the construction of a collaboration network, i.e., a graph of author nodes and co‐author links. In this context, the goal is to produce a co‐authorship graph with network characteristics that are close to those of the “true” collaboration network, so that meaningful network metrics can be determined.The algorithm we present here is fairly easily comprehended as it does not depend on any sophisticated AI techniques. This is important in the context of policy studies, in which we successfully applied it, as it enables policy makers to judge the soundness of the methodology with considerable confidence. It is also quite fast, making it possible to run large‐scale analyses (here, in the order of a hundred thousand publications and in the order of a million names to be disambiguated) on a moderately sized desktop computer within a few days.The algorithm is, finally, open to improvement via extensions that take into account additional kinds of fields in bibliographic records of publications to provide evidence that two occurrences of similar names belong to the same individual.
Book tagging on LibraryThing: How, why, and what are in the tags?
Authors: Bartley Peishan 
Published: January 2010

AbstractThe purpose of this exploratory study is to understand book tagging by investigating LibraryThing (LT) members' purposes for tagging; exploring how tags are used; and comparing member assigned tags with terms in corresponding MARC records. The results show that LT members tag mostly for personal reasons, especially to manage their own collection, but they also tag to assist others to find a book. Once assigned, LT members use the tags to search and retrieve books, to gain information about books, and most importantly, to assist with personal collection management. Contrary to users of other popular tagging systems such as Flickr, LT members do not perceive social networking as an important factor when assigning and using the tags. The study also reveals that book tags by users vary greatly from MARC records. When tags overlapped with the terms used in MARC records, the majority of the matching occurred in the fields of 600s (Subject Access Fields) and 245 (Title Statement). The findings of the study contribute to the understanding of how books are represented in LT members' conceptual spaces, and have implications on how libraries could employ user created tags in OPACs.
To what degree can log data profile a web searcher?
Authors: Jansen Bernard , Zhang Mimi , Booth Danielle , Park Daehee , Zhang Ying , Kathuria Ashish , Bonner Pat 
Published: January 2010

AbstractIn this paper, we report ongoing efforts in a large scale research project to develop methods for profiling individual Web search engine users by leveraging data recorded in the transaction logs of search engines. Our research aim is to investigate how completely one can profile a Web searcher using log data. Taking a broad brush approach, we present an array of profiling attributes to illustrate the spectrum of user characteristics possible from log data. Specifically, we present ongoing research for determining a user 's location, geographical interest, topic of interest, level of interest, the degree of commercial intent, whether the user plans to make a purchase, and whether the user will click a link. We present the state of our ongoing research in user profiling along with that of other researchers. Our findings show that one can develop a fairly robust profile of a Web searcher using log data. We also discuss issues of determining the specific identity of the user. We conclude with a discussion of the implications for the areas of system development, online advertising, privacy, and policies concerning the use of such profiling.
Users' views on country‐specific search engine results
Authors: Bar‐Ilan Judit , Levene Mark 
Published: January 2010

AbstractIn this paper we report the results of a user study that compared different country‐specific search results of Google and Live search. The users were Israelis and the search results came from six sources: Google Israel, Google.com, Google UK, Live Search Israel, Live Search US and Live Search UK. The users evaluated the results of nine pre‐selected queries, created their own preferred ranking and picked the best ranking from the six sources. The results indicate that the group of users in this study liked most the local Google interface, i.e. Google succeeded in it its country‐specific customization of search results. Live.com was much less successful in this aspect. However search engines are highly dynamic, thus these findings have to be viewed cautiously. The main contribution of the paper is a two‐phase methodology for comparing and evaluating search results from different sources.
Tags as keywords – comparison of the relative quality of tags and keywords
Authors: Syn Sue Yeon , Spring Michael B. 
Published: January 2010

AbstractTags assigned by users are considered to have potential in categorizing web resources despite the fact that they do not use a controlled vocabulary and are contributed by non‐experts. This study explores the potential of using tags to replace controlled vocabulary as a method of organizing web resources. Author‐assigned keywords and users‐assigned tags for a shared data collection are compared. The data was gathered from scientific papers that have both author‐assigned keywords and user‐assigned tags. Author‐assigned keywords and user‐assigned tags were compared using similarity measurements, classification systems, and clustering methods.
Identifying undergraduate media literacy skills: An exploratory study of faculty perceptions
Authors: Bordac Sarah 
Published: January 2010

AbstractGiven the complex nature of the multi‐media landscape available to undergraduate students, understanding how and how well these users make decisions in comprehending and critiquing media information has implications on the tools and quality of teaching and learning in the academy. In this research study, a small sample of faculty members who use visual content in their teaching were interviewed to learn what attributes they identify as important media literacy skills for students. The results support a model of core skills associated with media literacy. Findings from this exploratory study will inform a larger scale research project that investigates the assessment techniques for media literacy skills and based on which, develops a practical framework for media literacy assessment.
An empirical evaluation on textual results clustering for web search
Authors: Pu Hsiao‐Tieh , Chen Sih‐Ying , Kuo Pei‐Yi 
Published: January 2010

AbstractClustering web search results into dynamic clusters and cluster hierarchies has been shown to be promising in reducing the information overload typically found in the ranked list search engines. The study compared sixteen participants' search performance and subjective satisfaction level in using textual clustering and ranked list search interfaces towards conducting assigned and self‐designated search tasks. The results show participants searched slightly faster, better, and were more satisfied using the ranked list interface. However, it is worth noting that participants performed slightly well in easy type of questions with the clustering interface, and obtained non‐repetitive relevant results not found from using the ranked list interface. The study shows the clustering interface provides the values of highlighting prominent concepts and offering richer context for exploring, learning and discovering related concepts; yet it also induces certain degree of information uncertainty, lost, and anxiety. Discussions on the contrast view of clustering search and suggestions for future studies are also provided.