bluuebunny/crossref_metadata_2025_split huggingface dataset:
Community-based psychedelic integration and social efficacy: An ethnographic study in the Southeastern United States
Authors: Gezon Lisa L. 
Published: May 2024

AbstractBackground and aimsThis qualitative ethnographic study of a psychedelic integration group in the Southeastern United States contributes to an understanding of the role of supportive communities in processing psychedelic experiences. This article proposes the concept of ‘social efficacy’ to capture the importance of social relationships to the efficacy of psychedelics. Social efficacy refers to a source of efficacy that includes not just the immediate social environment in which psychedelics are experienced and processed, but also the broad range of social relationships and political economic and historical contexts that frame their use.MethodsThis year-long ethnographic research project took place with a psychedelic integration group in an urban center in the Southeastern United States. It was based on observation, interviews, and a focus group.ResultsOverall, the participants in the integration group see the group as critical to their ability to effectively process their psychedelic experiences. The group is important as a supportive community of like-minded people that facilitates enduring cognitive and affective transformation.ConclusionsCommunity-based non-therapeutic integration groups can play a vital role in the positive integration of psychedelic experiences, improving mental health and quality of life for users. The important role of community-based groups has significance for both the legalization and the medicalization of psychedelics. It highlights the need for safe and legal spaces in which people can talk about their psychedelic experiences and for medical models of efficacy that include social, relational elements.
Clinical case of urachal carcinoma treatment
Authors: Nurgaliyev N. S. , Ukolova E. A. , Satbaeva E. B. , Aydarkulov A. A. , Rakhimov G. T. 
Published: May 2024

Urachal carcinoma is a rare pathology of the lower urinary tract. In a review of the largest case series, five-year overall survival was about 50 %. The poor prognosis is mainly attributed to advanced stage of the disease due to relative absence of symptoms in localized disease, the difficulty of identification by cystoscopy, and the lack of clear consensus regarding investigation and treatment of localized and advanced disease.We report a case of treatment of a 46-year-old patient with primary urachal carcinoma. Cystoscopy revealed a lesion on the bladder closer to the apex. Magnetic resonance imaging of the pelvic organs revealed a picture of a malignant neoplasm of the bladder with growth into the paravesical tissue and the anterior wall of the bladder. The patient underwent surgery followed by adjuvant chemotherapy.
Salvage lymph node dissection in nodal oligorecurrent prostate cancer: literature review and our experience
Authors: Shirokorad V. I. , Izmailov A. A. , Lupashko D. G. 
Published: May 2024

Background. Despite improved surgical techniques in treatment of prostate cancer, biochemical recurrence after surgery (increase in prostate-specific antigen level (PSA) by 0.2 mg/mL or higher in 2 consecutive measurements) develops in 20–40 % of patients depending on disease stage and tumor aggressiveness. To diagnose the source of biochemical recurrence, patients undergo positron emission tomography/computed tomography (PET/CT) with 18F- or 68Ga-labeled prostate-specific membrane antigen (PSMA). Both tracers showed comparable results in phase III trials with positive prognostic values between 84 and 92 % at PSA level ≥1 ng/mL. A number of articles has been published demonstrating the effectiveness of salvage lymph node dissection (SLND) after local treatment of carefully selected patients in the long-term. According to the results of these publications, drug therapy in patients with oligometastatic progression can be delayed by years and potentially increse overall survival.Aim. To analyze the literature and our own experience of SLND in treatment of nodal oligorecurrent prostate cancer.Materials and methods. At the Clinic of the Moscow City Oncological Hospital No. 62 between 2012 and 2023 in the frame-work of the clinical protocol, 32 patients with nodal oligorecurrent prostate cancer underwent SLND after radical prostatectomy: 12.5 % (4 of 32) of patients through open access, 87.5 % (28 of 32) through laparoscopic access.Results. Two groups were identified: 1st group (n = 20) of patients without androgen deprivation therapy (ADT) and/or external beam radiotherapy after SLND; 2nd group (n = 12) of patients receiving immediate ADT and/or external beam radiotherapy after SLND.In the 1st group, an additional criterion of SLND effectiveness was introduced, namely, PSA response: complete, partial PSA response, or its absence. In patients with partial PSA response (n = 4), its depth was evaluated; it varied between 16 and 83 %. PSA response depth did not correlate with duration of response.Complete PSA response was achieved in 60 % (n = 12) of patients. Duration of response varied between 3 and 133 months without additional treatment.In the 1st group, median follow-up was 6 months and progression-free survival was 18 months; in the 2nd group, median follow-up was 31 months and median progression-free survival was 41.9 months (p = 0.84456).Conclusion. The standard of treatment for patients with metastatic hormone-sensitive prostate cancer is ADT in combination with 2nd generation antiandrogens. Improvement and availability of PET/CT with PSMA allowed to identify patients with nodal oligorecurrent prostate cancer in which SLND without ADT allows to achieve complete PSA response in 60 % of cases and delay ADT associated with a number of adverse events. SLND is characterized by low number of postoperative complications, short hospital stay.
Stages of research and development of therapeutic approaches for Duchenne myodystrophy. Part II: etiotropic approaches
Authors: Kochergin-Nikitskiy K. S. , Smirnikhina S. A. , Lavrov A. V. 
Published: May 2024

Duchenne muscular dystrophy is one of the most common inherited muscular dystrophies. The cause of this disease with an X‑linked recessive type of inheritance is mutations in the DMD gene, leading to the absence of the dystrophin protein this gene encodes or its impaired function. Loss of dystrophin leads to severe degenerative processes in patients, especially in muscle tissue, with impaired muscle function, loss of ability to move independently, respiratory failure, cardiomyopathies, etc.The collective efforts of many researchers over the years since the 19th century, when the diseases was described, not allowed to achieve a cure or significantly influencing the trajectory of the illness. The only notable impact on the disease course has come with the integration of corticosteroid medications into Duchenne muscular dystrophy therapy. While their application can decelerate disease progression and extend the average life expectancy up to 30–40 years, it comes with substantial adversely affects influencing patients’ quality of life.Certain hopes were associated in recent decades with the development of etiotropic therapy for Duchenne muscular dystrophy, aimed at restoration of the dystrophin’s function. Some of such approaches were based on the overcoming of the effect of premature stop codons in the DMD gene using aminoglycoside antibiotics, ataluren, etc. Several subsequent studies were conducted to explore the applicability of exon‑skipping approaches in the dystrophin gene, aimed at excluding exons carrying pathogenic genetic variants. The rationale for these studies was the available information about a milder course of the disease associated with a truncated but functional dystrophin. The possibility of the pathology correction by means of introduction of the exogenous functional DMD gene copy from the outside (gene replacement therapy) has been under study since the beginning of the 20th century. One of the most promising directions in recent years was the development of approaches related to genome editing, which, unlike the methods mentioned above, allows for the permanent correction of the underlying cause of genetic diseases. Some of corresponding drugs have already received approval, while others, related to gene therapy, are at the stage of clinical trials.
CICLO DA CARREIRA E DO DESENVOLVIMENTO PROFISSIONAL DOCENTE: CONCEITOS, DEFINIÇÕES E MODELOS
Authors: Mohn Rodrigo Fideles Fernandes , Ribeiro da Costa Návia Regina , Curado Pinheiro Cordeiro da Silva Kátia Augusta 
Published: May 2024

Neste artigo, discorremos acerca dos conceitos, das definições e dos modelos referentes ao Ciclo da Carreira Docente (CCD), buscando discutir se há diferença entre este e o Desenvolvimento Profissional Docente (DPD). Ainda, explanaremos sobre a questão do ciclo relacionado ao tempo de carreira docente, fazendo uma análise sobre o processo de inserção do profissional neste âmbito, discutindo a relação entre a idade cronológica e a idade de ingresso no mundo do trabalho. Para tanto, estabelecemos um paralelo entre a pesquisa de Huberman (1992) e de outros autores, e consideramos que o CCD estudado não é algo fechado, mas aponta para possibilidades de se pensar e estudar a carreira docente, sendo que um professor, independentemente do tempo de atuação como questão central para definir a sequência normativa, pode vivenciar outra fase da carreira, aliada às condições objetivas do trabalho.
Facile synthesis of nanoscale CuO and NiO via the PVA-assisted sol-gel method and their exploration in the catalytic epoxidation of styrene
Authors: Bepari Ruhul Amin , Mochahari Nabajyoti , Siddique Kibriya , Das Birinchi Kumar 
Published: May 2024

The full-text of the article will be published in the English version of the journal "Catalysis in Industry" No. 4, 2024.Both nanoscale copper oxide and nickel oxides, with diameter 17 and 25 nm respectively, have been synthesized via an easy sol-gel method using polyvinyl alcohol. The method involves the simple dispersion of metal ions (M2+ = Cu or Ni) into the PVA gel and subsequent calcination of the dried gel at 400 °C for 3 h. The synthesized oxide materials are characterized by different physical tools like TGA, powder XRD, SEM, TEM and DRS UV-visible spectroscopic technique. The oxides are found to be very efficient catalysts in the epoxidation of styrene. CuO gives 87 % styrene conversion and 88 % SO selectivity while, NiO gives 69 % styrene conversion and 80 % with TBHP as an oxidant at the end of 6 h. Both the catalysts can suitably be reused for several successive runs without appreciable loss in activity and selectivity. The cost-effective synthesis, excellent catalytic performance and reusability make these oxides promising catalysts for the industrial use.
New, promising, domestic hybrids smooth-fruited cucumber for light culture
Authors: Ruslan A. Gish , Tishchenko L. A. 
Published: May 2024

Relevance. Innovations in modern greenhouse complexes necessitate the creation of new technological cucumber hybrids for them, an important component of which is their comprehensive assessment in production conditions.Materials and methods. In 2023, experiments were conducted in the Krymsk (Krasnodar Territory) SC “Gavrish” with 9 new parthenocarpic hybrids of cucumber F1 smooth type in 2 repetitions of 10 plants each. Hybrids were grown in a winter greenhouse under light culture conditions in winter-spring and summer-autumn rotations. The technology of growing the crop is maintained in accordance with the requirements adopted in the V light zone. The assessment of economically valuable features was carried out according to generally accepted methods.Results. The early and total yields, marketability of the grown hybrids in two crop rotations, the degree of their resistance to real powdery mildew and adaptability of cultivation in crop rotations have been established. A comparative assessment of the potential of new hybrids with the generally accepted F1 analogue of Meva in the region has been carried out.Conclusions. The new parthenocarpic smooth-fruited cucumber hybrids of GC “Gavrish” F1 Metreng, Model 4560/19, Model 166/20 can act as an import substitution.
A variety of potato cultivars from the VIR World Collection in northern conditions
Authors: Zhigadlo T. E. 
Published: May 2024

Relevance. Potatoes are one of the most popular agricultural crops in Russia. The unique chemical composition characterizes potatoes as a valuable food product in the diet of the population. One of the important factors for increasing and stable potato yields is the selection of the optimal assortment for each region of the Russian Federation. Therefore, the varieties most adapted to local growing conditions should be used in production. The world potato collection allows solving various issues of modern breeding, such as: early maturity, resistance of tubers to various diseases, seed quality, adaptation to climatic stresses, history and systematics. The study and evaluation of new potato breeding varieties makes it possible to identify promising source material for the creation of future varieties suitable for cultivation in the northern regions of the country.The purpose of this study is to characterize the studied potato samples in extreme climate conditions.Material and methodology. In 2013-2023, 543 potato samples from the World Collection of VIR were studied at the experimental field of the Polar Experimental Station VIR branch according to the main biological and economically valuable characteristics. For a comprehensive assessment of the varieties according to the main economic and biological characteristics, phenological observations were carried out, the harvest was taken into account during early and final harvesting, including the structure of the crop. Visual assessment of diseases was carried out in the field and during storage. Starch was determined in the laboratory. All basic accounting is performed according to the VIR methodology.Results and discussion. Over the years, 15 potato varieties with the best characteristics of economically valuable traits have been identified. According to the results of the final harvest, 6 varieties had a stable harvest – Favorit, Meteor, Tekes, Severny, Gusar, Lingonberry. The yield of these varieties was 1034-1409 g/bush.
Food independence and technological sovereignty of Russia in the vegetable growing sector
Authors: Pivovarov V. F. , Soldatenko A. V. , Pyshnaya O. N. , Gurkina L. K. , Pinchuk E. V. 
Published: May 2024

Relevance. The state of Russia's agro-industrial complex determines the country's national security, as it provides the population with quality agricultural products and raw materials, which affects state sovereignty. According to a number of analysts, in commercial vegetable growing, about 80 % of sown areas are annually sown with imported varieties and hybrids, and this is a vulnerability in ensuring the industry's independence and the country's competitiveness. Strengthening technological sovereignty in the field of vegetable production is one of the priorities of the state agrarian policy, as well as the main focus of scientific organisations and private companies.Results. Federal State Budgetary Scientific Institution Federal Scientific Vegetable Center (FSBSI FSVC) is a major scientific center of the industry, which can compete with foreign companies with its breeding achievements. The article shows the leading position in the breeding of vegetable and melon crops FSBSI FSVC, which actively conducts research on private genetics, biotechnology, contributing to the acceleration of the breeding process; varieties and hybrids are created that combine consistently high productivity, early maturity, resistance to biotic and abiotic stressors, high quality products with an optimal content of biologically active substances to obtain potential raw materials and products of functional action; development of resource-saving, environmentally safe, high-precision technologies for cultivation of vegetable and melon crops, taking into account species and varietal characteristics, as well as scientific bases and practical recommendations for production of original seeds taking into account zonal specifics.However, there are problems hindering the introduction of breeding achievements: the increased cost of registration of breeding achievements in the State Register of Selection Achievements of the Russian Federation of the Russian Federation, bureaucratic difficulties in their approbation, which arose for breeders after the adoption of the new law "On Seed Production". In order to solve the problems of seed production, the Ministries in charge of vegetable production have launched a sub-programme "Development of breeding and seed production of vegetable crops", which aims to increase the production of domestic competitive seeds and brings together the state, science and business.
Improvement of elements of zonal agro-technology of sweet pepper cultivation on seeds under irrigation conditions of Astrakhan region
Authors: Gulin A. V. , Mukanov M. V. , Karakadzhiev A. S. 
Published: May 2024

Relevance. The purpose of the research was to improve the elements of zonal agricultural technology for cultivating a new variety of sweet pepper Zarnitsa, to study the possibility of increasing productivity, reducing production costs during its seed production through the use of a non-seedling method of cultivation in irrigated conditions and the plant growth regulator Zircon, R.Methodology. Experimental studies were carried out on the experimental field of All-Russian Research Institute of Irrigated Vegetable and Melon Growing (Astrakhan region) in 2022-2023. The establishment of the field experiment and the carrying out of records and observations in the experiment were carried out in accordance with generally accepted methods.Results. It was found that with the seedless method of growing sweet pepper, the period from sowing to the start of fruit harvesting was 12 days shorter. Sweet pepper plants in the seedling method during the fruiting phase had advantages: in plant height by 9.3%, in the number of lateral shoots by 21.2%, in leaf weight by 7.0%, in average fruit weight by 6.1%. The highest yield, on average 31.6 t/ha, was obtained using the seedling method; when sowing seeds in the ground, it was 3.8% lower. Replacing the seedling method of cultivation with a non-seedling method contributed to a reduction in production costs by 74.7 thousand rub./ha, production costs by 1.9 thousand rub./t, production profitability by 1.2 times, due to savings in labor resources and working capital for growing and planting seedlings. Replacing the seedling method of cultivation with a non-seedling method helped reduce production costs by 74.7 thousand rub./ha, production costs by 1.9 thousand rubles/t, the profitability of production of sweet pepper products and seeds by 1.2 times, due to savings labor resources, working capital for growing, planting seedlings. A single treatment with the plant growth regulator Zircon, P (30 ml/ha) at the beginning of flowering contributed to a significant increase in plant biometric parameters: height by 12.2%, number of lateral shoots by 30.8%, leaf weight by 14.3%, yield by 2.4 t/ha (7.9%), compared to the control (30.4 t/ha), an increase in sugar content by 0.2%, vitamin C by 4 mg% and seed yield by 9 kg/ha (8.7%). The sowing qualities of sweet pepper seeds in all variants of the experiment met the standard requirements and were – 94-95% in terms of germination and – 92-94% in terms of germination energy. The highest level of profitability of 204.9% was obtained as a result of using a growth regulator; in the option without treatment it was lower by 14.4%.
Methods of increasing the seed productivity of the new variety of sage medicinal Fioletovy Aromat
Authors: Tropina N. S. , Sidelnikov N. I. 
Published: May 2024

Relevance. Salvia officinalis L. is an important essential oilseed crop with anti-inflammatory, antimicrobial and antioxidant properties. Providing the pharmaceutical industry with raw materials of Salvia in full is possible due to the expansion of production areas and the availability of the maximum amount of highquality seed material of new promising varieties.Methods. In 2019-2022 in the conditions of the North Caucasus branch of VILAR on a new variety of Salvia Fioletovy aromat II year of vegetation by staging small-scale experiments were conducted to study the systematic application of organomineral fertilizer – EcoFus and growth regulators of different mechanism of action – Zircon, Epin-extra, retardant Hardy to increase seed productivity and seed quality. The area of the experimental plots was 12 m2. Treatment with EcoFus was carried out at the beginning of regrowth, and with bioregulators – during the budding phase. The consumption of the working solution is 300 l/ha. Control variants of medicinal crops were treated with water.Results. Application of EcoFus in the phase of regrowth contributed to the activation of the intensity of photosynthesis and increase in the accumulation of plastic substances, which allowed plants to enter the generative phase earlier, the budding phase came 2-3 days earlier than in the control. Subsequent treatment of budding plants with growth regulators led to earlier and more friendly flowering, the time of seed ripening was reduced by 3-4 days. The highest efficiency was observed in the variants of joint application of EcoFus with Zircon or Hardy, where the number of inflorescences on plants increased, seed setting and seed productivity increased by 37-42%, seed quality also improved – weight of 1000 seeds increased by 9-10% and germination by 6-7%.
<sup>87</sup>Sr/<sup>86</sup>Sr isotopic composition of wine: uses and limitations
Authors: Erban Kochergina Yulia , Pavloušek Pavel , Šanda Martin , Hora John M. 
Published: May 2024

Isotopic 87Sr/86Sr fingerprints are increasingly applied to identify wine provenance, i.e., the geology of the source region. We present 87Sr/86Sr analyses of 27 samples of commercial wines from Central Europe, Southern Moravia, Czech Republic, done by thermal ionisation mass spectrometry (TIMS), and compare these data with isotopic compositions of bulk soil, bio-available soil fraction groundwater and precipitation. 87Sr/86Sr ratios of wines vary from 0.708 to 0.710 and correspond to those in groundwater and leachates from soils. We have divided the rocks (soils) into three groups according to their 87Sr/86Sr isotopic composition: (i) below that of precipitation (0.700–0.709); (ii) similar to precipitation (0.709–0.710); (iii) above that of open-area precipitation (> 0.710). We describe how bedrock from each group can affect the isotopic composition of juice, must (i.e., juice + pomace) or wine. Wines from South Moravia have very similar 87Sr/86Sr, independent of cultivars and vintage. We conclude that the groundwater sample could be used as a tracer for bio-available Sr isotopic composition. We recommend analysing the rainwater and groundwater or/and leachate from soil together with wine samples and discuss the limitations of 87Sr/86Sr use in wine as a geological tracer. We offer a simple predictive model that connects the wine-leachate-bulk rock/soil Sr isotopic composition. To interpret isotopic data correctly, careful assessment of geochemical context, i.e., isotope systematics in bedrock and soil, is necessary.