bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Chemoselective Thioacetalization of Aldehydes Catalyzed by a MCM‐41‐Supported Mercapto Ruthenium Complex.
Authors: Li Jianying , Xie Shiyun , Cheng Li , Liu Jun , Cai Mingzhong 
Published: February 2012

AbstractVarious aromatic and aliphatic aldehydes are easily converted into cyclic and acyclic dithioacetals.
ChemInform Abstract: Radical Addition Reaction of Perfluoroalkyl Iodides with 2,3‐Allenols and the Pd‐Catalyzed Kinetic Resolution via Sonogashira Coupling Reaction.
Authors: Ma Zhichao , Zeng Rong , Fu Chunling , Ma Shengming 
Published: February 2012

AbstractRadical addition reaction of perfluorobutyl iodide towards allenols (I), (VI) and (IX) provides a mixture of E/Z‐isomeric allylic alcohols.
ChemInform Abstract: The First Catalytic Asymmetric Addition of Diethylzinc to Aldehyde Promoted by Chiral Thiourea.
Authors: Qiao Zhi Guo , Shen Tian Hua , Fu Zhen Fang , Li Jun Qi , Wang Hong , Song Qing Bao 
Published: February 2012

AbstractA C2‐symmetric thiourea is employed as ligand to give the alkylated products with up to 87% e.e.
ChemInform Abstract: Synthesis of Novel Amide Molecular Tweezers under Solvent‐Free Conditions Using Microwave Irradiation.
Authors: Zeng Bitao , Zhou Lijun , Li Xiangbiao , Zhao Xianming , Zhao Zhigang , Deng Mei 
Published: February 2012

AbstractThe molecular tweezers (V) (12 examples) exhibit good recognition properties for Cl‐, Br‐, I‐, and Ac‐O‐ ions.
ChemInform Abstract: Efficient Preparation of ortho‐Aminobenzenesulfonamides Using Ligand‐Free Copper(I)‐Catalyzed Amination.
Authors: Bahlaouan Zineb , Thibonnet Jerome , Duchene Alain , Parrain Jean‐Luc , Elhilali Mostafa , Abarbri Mohamed 
Published: February 2012

AbstractA simple method is presented for the preparation of pharmaceutically important title compounds (III).
ChemInform Abstract: Pd(II)‐Catalyzed Formal O—H Insertion Reactions of Diazonaphthoquinones to Acetic Acid: Synthesis of 1,2‐Naphthalenediol Derivatives.
Authors: Kitamura Mitsuru , Kisanuki Masato , Sakata Rie , Okauchi Tatsuo 
Published: February 2012

AbstractThe position of the acetyl group of the products (III)/(IV) and (VI)/(VII) is undetermined although one major product is obtained in general.
ChemInform Abstract: Metal‐Free C—H Cross‐Coupling Toward Oxygenated Naphthalene‐Benzene Linked Biaryls.
Authors: Dohi Toshifumi , Ito Motoki , Itani Itsuki , Yamaoka Nobutaka , Morimoto Koji , Fujioka Hiromichi , Kita Yasuyuki 
Published: February 2012

AbstractA perfluorinated hypervalent iodine reagent is successfully applied as an extreme single‐electron‐transfer oxidant in the intermolecular C—H cross‐coupling reaction.
ChemInform Abstract: Palladium‐Catalyzed C‐2 or C‐5 Direct Arylation of 3‐Substituted Thiophenes with Aryl Bromides.
Authors: Dong Jia Jia , Roy David , Roy Reny Jacob , Ionita Marina , Doucet Henri 
Published: February 2012

AbstractThe regioselectivity of the reaction strongly depends on the substituent at the thiophene substrate.
ChemInform Abstract: Cytotoxic and Antivascular 1‐Methyl‐4‐(3‐fluoro‐4‐methoxyphenyl)‐5‐(halophenyl)‐imidazoles.
Authors: Biersack Bernhard , Muthukumar Yazh , Schobert Rainer , Sasse Florenz 
Published: February 2012

AbstractNew N‐methylimidazole bridged analogues (VI) (8 examples) of combretastatin A‐4 are synthesized and evaluated for their cytotoxicity and antiangiogenic activity.
ChemInform Abstract: Boric Acid‐Catalyzed Direct Condensation of Carboxylic Acids with Benzene‐1,2‐diamine into Benzimidazoles.
Authors: Maras Nenad , Kocevar Marijan 
Published: February 2012

AbstractDirect cyclocondensation of o‐phenylenediamine (I) with a variety of carboxylic acids is readily achieved using catalytic amounts of boric acid in refluxing toluene under Dean‐Stark conditions.
ChemInform Abstract: Expeditious Preparation of Isoxazoles from Δ2‐Isoxazolines as Advanced Intermediates for Functional Materials.
Authors: Vilela Guilherme D. , da Rosa Rafaela R. , Schneider Paulo H. , Bechtold Ivan H. , Eccher Juliana , Merlo Aloir A. 
Published: February 2012

AbstractNitrile oxides, generated in situ from oximes of type (I), undergo regioselective 1,3‐dipolar cycloaddition with styrenes to yield isoazolines (III).
ChemInform Abstract: Chiral Cinchona Alkaloid‐Thiourea Catalyzed Mannich Reaction for Enantioselective Synthesis of β‐Amino Ketones Bearing Benzothiazol Moiety.
Authors: Lin Peng , Song Baoan , Bhadury Pinaki S. , Hu Deyu , Zhang Yuping , Jin Linhong , Yang Song 
Published: February 2012

AbstractThe preparation of catalyst QTU is presented as well.
ChemInform Abstract: Synthesis and Characterization of Cannabimimetic Aminoalkylindole Based 5‐(4‐Alkyl‐1‐naphthoylamino)‐1,3,4‐thiadiazole‐2‐sulfonamides.
Authors: Zengin Gulay , Nalbantbasi Zehra , Zengin Huseyin , Turkmen Hasan 
Published: February 2012

AbstractAcyl chlorides, derived from naphthoic acids (I), react with deacetylated acetazolamide (II) in the presence of N‐ethyl‐morpholine to provide structures incorporating 1‐naphthoyl groups of cannabimimetic aminoalkylindoles and a five‐membered heteroring typical for antiglaucoma drugs.
ChemInform Abstract: Copper(II)‐Catalyzed Asymmetric Henry Reaction of o‐Alkynylbenzaldehydes Followed by Gold(I)‐Mediated Cycloisomerization: An Enantioselective Route to Chiral 1H‐Isochromenes and 1,3‐Dihydroisobenzofurans.
Authors: Lu Dengfu , Zhou Yirong , Li Yajun , Yan Shaobai , Gong Yuefa 
Published: February 2012

AbstractThe ratio of products is dependent on the electronic nature of the substituents.
ChemInform Abstract: A Pd‐Mediated New Strategy to Functionalized 2‐Aminochromenes: Their in vitro Evaluation as Potential Antituberculosis Agents.
Authors: Reddy T. Ram , Reddy L. Srinivasula , Reddy G. Rajeshwar , Nuthalapati Venkata Subbaiah , Lingappa Y. , Sandra Sandhya , Kapavarapu Ravikumar , Misra Parimal , Pal Manojit 
Published: February 2012

AbstractA new compound library based on the 2‐aminochromene framework is synthesized via a novel strategy involving a multi‐component reaction and Pd‐catalyzed C—C bond forming reaction.
ChemInform Abstract: 1‐Hydroxy‐8‐methyl‐1,4,8‐triazaspiro[4.5]decan‐2‐one and Its (.+‐.)‐3‐Methyl Homologue: Regioselective Synthesis and in vivo Evaluation as Adjuvants in Leukemia Chemotherapy.
Authors: Vystorop Igor V. , Konovalova Nina P. , Sashenkova Tat'yana E. , Berseneva Elena N. , Chernyak Alexander V. , Fedorov Boris S. , Kostyanovsky Remir G. 
Published: February 2012

AbstractThe condensation reaction of glycine and alanine hydroxamic acids with piperidone (II) regioselectively affords the title spiro compounds (III), which are capable of enhancing sensitivity of P388 and L1210 leukemias in mice models to the known anticancer drugs cisplatin and cyclophosphamide.
ChemInform Abstract: N‐(Substituted benzyl)‐3,5‐bis(benzylidene)‐4‐piperidones: Synthesis and Preliminary Antileukemia Activity. Part 1.
Authors: Wang Jing , Meng Wen , Ni Zhenjie , Xue Sijia 
Published: February 2012

AbstractThe starting material (I) is prepared in a three‐step synthesis.
ChemInform Abstract: A General Protocol for the Solvent‐ and Catalyst‐Free Synthesis of 2‐Styrylquinolines under Focused Microwave Irradiation.
Authors: Staderini Matteo , Cabezas Nieves , Bolognesi Maria Laura , Menendez J. Carlos 
Published: February 2012

AbstractThe reaction generates a C—C double bond in a very efficient manner with only AcOH as the side product.
ChemInform Abstract: Selective Synthesis of Some Imidazopyridine‐Fused Chromones.
Authors: Costa Marta , Proenca M. Fernanda 
Published: February 2012

AbstractIntramolecular cyclization of iminochromenylpyridinium chlorides (I) in the presence of DABCO provides access to title imidazopyridine‐fused chromones (II) in moderate yields.
ChemInform Abstract: One‐Pot Three‐Component Synthesis of Functionalized Spirolactones by Means of Reaction Between Aromatic Ketones, Dimethyl Acetylenedicarboxylate, and N‐Heterocycles.
Authors: Maghsoodlou Malek Taher , Habibi‐Khorassani Sayyed Mostafa , Moradi Abbas , Hazeri Nourallah , Davodi Amir , Sajadikhah Seyed Sajad 
Published: February 2012

AbstractThe present procedure has the advantage that the reactions are performed under neutral conditions and that the substances can be mixed without any activation or modification.
ChemInform Abstract: Synthesis of Quinoxaline Derivatives Using TiO2 Nanoparticles as an Efficient and Recyclable Catalyst.
Authors: Alinezhad Heshmatollah , Tajbakhsh Mahmood , Salehian Fatemeh , Biparva Pourya 
Published: February 2012

AbstractTiO2 nanoparticles are prepared via a sol‐gel method and shown to be an efficient catalyst for the synthesis of quinoxaline derivatives.
ChemInform Abstract: Microwave‐Assisted Aqueous Synthesis: A Rapid Approach to Polyfunctionalized Indoline‐Spiro Benzofurodiazepines.
Authors: Wang Shuliang , Cheng Chuang , Gong Feng , Wu Feiyue , Jiang Bo , Zhou Jianfeng , Tu Shujiang 
Published: February 2012

AbstractThe reaction is carried out under environmentally benign conditions.
ChemInform Abstract: Reactions of 2‐(5‐Methyl‐2‐phenyl‐2H‐1,2,3‐diazaphosphol‐4‐yl) ‐4H‐1,3,2‐benzodioxaphosphinin‐4‐one with Chloral and Hexafluoroacetone.
Authors: Mironov Vladimir F. , Ivkova Gulnara A. , Abdrakhmanova Liliya M. , Mironova Ekaterina V. , Krivolapov Dmitry B. , Konovalova Irina V. 
Published: February 2012

AbstractInterestingly, the title diazaphospholyldioxaphosphininone (I) reacts with carbonyl compounds exclusively at the more reactive P(III) atom of the dioxaphosphinine cycle.
ChemInform Abstract: Neat Synthesis and Antioxidant Activity of α‐Hydroxyphosphonates.
Authors: Rao K. Uma Maheswara , Sundar Ch. Syama , Prasad S. Siva , Rani C. Radha , Reddy C. Suresh 
Published: February 2012

AbstractSome α‐hydroxyphosphonates, especially derivative (IIIc), show appreciable antioxidant activities.
ChemInform Abstract: A New Friedelane Triterpenoid from the Branches of Maytenus gonoclada (Celastraceae)
Authors: Silva Fernando C. , Rodrigues Vanessa G. , Duarte Lucienir P. , Silva Gracia D. F. , Miranda Roqueline R. S. , Filho Sidney A. V. 
Published: February 2012

Abstractstructure and stereochemistry of the new triterpenoid (I)
ChemInform Abstract: Concise Synthesis of Pelanserine (IIIa), Goshuyuamide II (VII), and Wuchuyuamide II (VIII) with Quinazolinedione Nuclei.
Authors: Li Xin , Lee Yong Rok , Kim Sung Hong 
Published: February 2012

AbstractEfficient and concise syntheses of the potent antihypertensive agent pelanserine (IIIa) and the two naturally occurring alkaloids (VII) and (VIII) are developed utilizing the formation of quinazolinedione nuclei (III) from isatoic anhydride as key step.
ChemInform Abstract: Potent Antiprotozoal Activity of a Novel Semi‐Synthetic Berberine Derivative.
Authors: Kinghorn A. Douglas , et al. et al. 
Published: February 2012

AbstractThe semi‐synthetic berberine analogue (I) reveals nanomolar level potency against in vitro models of leishmaniasis, malaria, and trypanosomiasis, and shows activity in an in vivo visceral leishmaniasis model.
ChemInform Abstract: Synthesis, α‐Adrenoceptors Affinity and α1‐Adrenoceptor Antagonistic Properties of Some 1,4‐Substituted Piperazine Derivatives.
Authors: Marona H. , Kubacka M. , Filipek B. , Siwek A. , Dybaia M. , Szneler E. , Pociecha T. , Gunia A. , Waszkielewicz A. M. 
Published: February 2012

AbstractA series of 1,4‐substituted piperazine derivatives (I) are synthesized and evaluated for affinity towards α1‐ and α2‐receptors by radioligand‐binding assay.
ChemInform Abstract: Laser‐Induced Chemical Liquid Phase Deposition of Metals: Chemical Reactions in Solution and Activation of Dielectric Surfaces
Authors: Kochemirovsky V. A. , Menchikov L. G. , Safonov S. V. , Bal'makov M. D. , Tumkin I. I. , Tver'yanovich Yu. S. 
Published: February 2012

AbstractReview: 92 refs.
Hybrid SPECT/cardiac‐gated first‐pass perfusion CT: locating transplanted cells relative to infarcted myocardial targets
Authors: Sabondjian Eric , Mitchell Andrea J. , Wisenberg Gerald , White James , Blackwood Kimberley J. , Sykes Jane , Deans Lela , Stodilka Robert Z. , Prato Frank S. 
Published: February 2012

PurposeA challenge with cardiac cell therapy is determining the location of cells relative to infarct tissue. As cells are viable following 111In‐labeling, and first‐pass CT imaging can identify regions of myocardial infarction, we evaluated the feasibility of a SPECT/CT system to localize cells relative to infarcted myocardium in a canine model.MethodsTen canines underwent surgical ligation of the left‐anterior‐descending artery and endothelial progenitor cells labeled with 111In‐tropolone were transplanted endocardially or epicardially. SPECT/CT was performed on day of transplantation, 4 and 10 days post‐transplantation. For each imaging session first‐pass perfusion CT was performed to delineate the area of reduced perfusion. SPECT and first‐pass CT images were fused and evaluated. Contrast‐to‐noise ratios (CNR) were calculated for 111In‐SPECT images to evaluate cell detection.ResultsThe zone of reduced perfusion was well delineated on first‐pass perfusion CT in all canines. The 111In signal was visualized within this zone in all cases. Analysis of the CNRs suggests that cells may be followed for 11 effective half‐lives using the images from first‐pass perfusion CT to provide the anatomic landmarks.ConclusionIn the setting of an acute myocardial infarction SPECT/[first‐pass perfusion CT] is an effective hybrid platform for the localization of cells in relation to the area of reduced blood flow. Copyright © 2012 John Wiley & Sons, Ltd.
Thalamocortical projections of the anterodorsal thalamic nucleus in the rabbit
Authors: Shibata Hideshi , Honda Yoshiko 
Published: February 2012

AbstractThe anterior thalamic nuclei consist of the anterodorsal (AD), anteroventral, and anteromedial nuclei, each of which are highly differentiated and may contribute to different aspects of various cognitive and memory functions. In particular, the AD is unique in that it is implicated in learning at the earliest stage of discriminative avoidance conditioning in the rabbit. To better understand the functional roles played by the AD in memory and learning processes, we analyzed the organization of thalamocortical projections of the AD in the rabbit, using the anterograde tracer biotinylated dextran amine and the retrograde tracer cholera toxin subunit B. The data show that the AD provides strong projections to layers I and IV of area 30 and to layers I, III, IV, and VI of area 29 in the retrosplenial cortex, and to layers I and III–VI of the presubiculum. The projections to the retrosplenial cortex are organized such that the rostral and caudal AD, respectively, project to the caudal and rostral retrosplenial cortex. In contrast, the projections to the presubiculum are not organized topographically. Other minor projections were also observed in the parasubiculum and part of the medial entorhinal area. These results indicate that the AD provides strong projections to the retrosplenial cortex and presubiculum, suggesting that these projections constitute essential pathways to these cortical regions for transmitting mnemonic information, such as a novel conditioning stimulus during the initial stage of avoidance learning. J. Comp. Neurol. 520:2647–2656, 2012. © 2012 Wiley Periodicals, Inc.
Neuroprotective effects of testosterone on motoneuron and muscle morphology following spinal cord injury
Authors: Byers James S. , Huguenard Anna L. , Kuruppu Dulanji , Liu Nai‐Kui , Xu Xiao‐Ming , Sengelaub Dale R. 
Published: February 2012

AbstractTreatment with testosterone is neuroprotective/neurotherapeutic after a variety of motoneuron injuries. Here we assessed whether testosterone might have similar beneficial effects after spinal cord injury (SCI). Young adult female rats received either sham or T9 spinal cord contusion injuries and were implanted with blank or testosterone‐filled Silastic capsules. Four weeks later, motoneurons innervating the vastus lateralis muscle of the quadriceps were labeled with cholera toxin‐conjugated horseradish peroxidase, and dendritic arbors were reconstructed in three dimensions. Soma volume, motoneuron number, lesion volume, and tissue sparing were also assessed, as were muscle weight, fiber cross‐sectional area, and motor endplate size and density. Contusion injury resulted in large lesions, with no significant differences in lesion volume, percent total volume of lesion, or spared white or gray matter between SCI groups. SCI with or without testosterone treatment also had no effect on the number or soma volume of quadriceps motoneurons. However, SCI resulted in a decrease in dendritic length of quadriceps motoneurons in untreated animals, and this decrease was completely prevented by treatment with testosterone. Similarly, the vastus lateralis muscle weights and fiber cross‐sectional areas of untreated SCI animals were smaller than those of sham‐surgery controls, and these reductions were both prevented by testosterone treatment. No effects on motor endplate area or density were observed across treatment groups. These findings suggest that regressive changes in motoneuron and muscle morphology seen after SCI can be prevented by testosterone treatment, further supporting a role for testosterone as a neurotherapeutic agent in the injured nervous system. J. Comp. Neurol. 520:2683–2696, 2012. © 2012 Wiley Periodicals, Inc.
Digital image correlation of bone sequential microscopic observations
Authors: Budyn Elisa , Jonvaux Julien , Hoc Thierry 
Published: February 2012

SUMMARYA method of image correlation is presented to study sequential microscopic observations of human Haversian cortical bone. Imaging biological tissues is sometimes challenging owing to their complex microstructures in particular when microcracks appear. Bone microfractures can be studied in micro compression tests where the progressive growth of small cracks is imaged by light microscopy. The two‐dimensional displacement field on the sample surface is then tracked by various digital image correlation methods based on cross‐correlation formulation. Because of the potential high number of sequential observations, the method calculates the displacements at given growth steps obtained either by direct comparison of the studied step and the undeformed initial state, called ‘direct correlation’, or by iterative comparisons of successive pairs of observations, called ‘gradual correlation’. In the gradual procedure, two cases are studied, referred to as ‘invariant gradual correlation’ and ‘varying gradual correlation’, when the correlation domain is transferred till the last observation or reinitialised for each image pairs. As bone is highly heterogeneous, two types of correlation procedures are considered with or without domain partition (WDP or WODP) delimiting material and strong discontinuities. The precision of the methods is specifically evaluated for experimental observations. Copyright © 2012 John Wiley & Sons, Ltd.
Metallomacrocyclic Complexes by Self‐Assembly of NiII and CuII Ions and Chelating Bis(N‐acylamidines)
Authors: Clodt Juliana Isabel , Fröhlich Roland , Eul Matthias , Würthwein Ernst‐Ulrich 
Published: February 2012

AbstractBis(N‐acylamidines) 1, which contain various rigid or flexible spacer units with different spatial orientations, are potent bis(bidentate) ligands for the coordination of metal ions. Treatment of 1 with NiII or CuII salts gave two 2:2 (3) and four 3:3 (4) metallomacrocycles by self‐assembly. The structures of the hitherto unknown products were determined by the geometry of the ligands that incorporate either linear or bent spacers between the two binding sites. Complex 3b is especially interesting due to its two vinyl subunits orientated perpendicular to the plane of the molecule. Complexes 3 and 4 crystallize in planar layers with intercalated solvent molecules (N,N‐dimethylformamide, dimethyl sulfoxide). The molecular structures of five coordination compounds in the solid state have been elucidated by X‐ray diffraction.
Direct Base‐Assisted C–N Bond Formation between Aryl Halides and Aliphatic Tertiary Amines under Transition‐Metal‐Free Conditions
Authors: Fang Yang , Zheng Yueqin , Wang Zhiyong 
Published: February 2012

AbstractDirect base‐mediated amination of aryl halides with aliphatic tertiary amines via an aryne intermediate was developed under transition‐metal‐free conditions. This operationally simple C–N bond‐coupling protocol could tolerate a variety of functionalized aryl halides as well as several aliphatic tertiary amines. Moreover, this environmentally benign process provides a new strategy for direct C–N bond formation.
Synthesis, Structure, and Photochemistry of 5,14‐Diketopentacene
Authors: Aotake Tatsuya , Ikeda Shinya , Kuzuhara Daiki , Mori Shigeki , Okujima Tetsuo , Uno Hidemitsu , Yamada Hiroko 
Published: February 2012

Abstract5,14‐α‐Diketopentacene, a structural isomer of 6,13‐α‐diketopentacene, was prepared from pentacene in three steps. In addition to the typical n–π* absorption of the diketone moiety at around 468 nm and the anthracene‐like absorption at 333, 349, and 367 nm, a broad absorption was observed at around 386 nm, which could be assigned to an intramolecular charge‐transfer absorption from anthracene to the diketone moiety. 5,14‐α‐Diketopentacene could be converted into pentacene quantitatively by photoirradiation at 405 and 468 nm in toluene with quantum yields of 2.3 and 2.4 %, respectively, and these values are higher than the quantum yield of 1.4 % obtained for 6,13‐α‐diketopentacene irradiated at 468 nm. The quantum yields in acetonitrile were lowered to 0.33 and 0.28 % with irradiation at 405 and 468 nm. The crystal structure of 5,14‐α‐diketopentacene showed a CH–π interaction and π–π stacking between neighbouring anthracene and benzene moieties. The lower solubility of 5,14‐α‐diketopentacene compared with the 6,13‐isomer could be explained by this crystal structure.
Enrichment of seismic ground motion databases using Karhunen–Loève expansion
Authors: Zentner Irmela , Poirion Fabrice 
Published: February 2012

SUMMARYBest estimate seismic analysis are generally based on time‐domain simulations of structural responses. The seismic load is then modeled by a stochastic process representing ground motion. For this purpose, the analyst can use recorded accelerograms or work with synthetically generated ones. The number of ground motion time‐histories available for a given scenario and site condition is limited and generally not sufficient for carrying out more advanced probabilistic structural response analysis. It is then necessary to have at our disposal methods that allow for generating synthetic accelerograms that realistically characterize earthquake ground motions. However, most of the methods proposed in literature for generating synthetic accelerograms do not accurately reproduce the natural variability of ground motion parameters (such as PGA, cumulative absolute velocity, and Arias intensity) observed for recorded time histories. In this paper, we introduce a new method for generating synthetic ground motion, based on Karhunen‐Loève decomposition and a non‐Gaussian stochastic model. The proposed method enables the structural analyst to simulate ground motion time histories featuring the properties mentioned above. To demonstrate its capability, we study the influence of the simulation method on different ground motion parameters and on soil response spectra. We finally compute fragility curves to illustrate the practical application of the proposed method. Copyright © 2012 John Wiley & Sons, Ltd.