bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glass fibre reinforced acrylic resin complete dentures: a 5‐year clinical study
Authors: Goguţă Luciana Maria , Bratu Dorin , Jivănescu Anca , Erimescu Raluca , Mărcăuţeanu Corina 
Published: June 2011

doi: 10.1111/j.1741‐2358.2010.00385.xGlass fibre reinforced acrylic resin complete dentures: a 5‐year clinical studyBackground and objectives:  The aim of the study was to establish the wear resistance of the glass fiber reinforced complete dentures comparative to the traditional acrylic complete dentures.Materials and methods:  Complete new dentures were made to replace old fractured ‘un’‐reinforced acrylic dentures. The total number of dentures was 30 and woven E‐glass fibre reinforcements were used in maxillary complete dentures. Unidirectional E‐glass fibre reinforcements were used as partial fibre reinforcements in mandibular complete dentures. Ten complete acrylic un‐reinforced dentures were used as control. The follow‐up period was 5 years and the recalls were made at 6 months.Results:  After 5 years of wearing the new dentures, the control dentures suffered seven fractures. After 5 years all the mandibular reinforced dentures were in good shape. The maxillary complete reinforced dentures suffered four partial fractures. Fracture lines were restricted by the glass fibre net and the patients could still use their dentures.Conclusion:  Pre‐impregnated E‐glass fibre nets and polymer pre‐impregnated E‐glass unidirectional fibres are useful in reinforcing acrylic resin complete dentures especially were heavy occlusal forces are involved. Glass fibre reinforcement will be applied on the tension side in both cases (total fibre reinforcement and partial fibre reinforcement). The reinforcement cannot replace the necessary linings and occlusal adjustments.
Clinical diagnosis and outcomes for Troponin T ‘positive’ patients assessed by a high sensitivity compared with a 4th generation assay
Authors: Jairam Sumeshni , Jones Peter , Samaraie Luay , Chataline Alexei , Davidson James , Stewart Ralph 
Published: June 2011

AbstractBackground: High sensitivity troponin T (hsTnT) detects lower levels of troponin T with greater precision than the 4th generation (cTnT) assay. However, the clinical implications of this are uncertain.Objectives: Primary: Describe the proportion of patients who test ‘positive’ with hsTnT but negative with cTnT. Secondary: Determine proportion in each group with an adverse event (representation, AMI or died) within 90 days of the index test.Method: 161 patients samples were tested with cTnT and hsTNT assays. McNemar's test was used to compare paired samples. Electronic medical records were reviewed, with discharge diagnosis and 90 day outcomes determined blind to hsTnT results. Patients were then classified as ‘TnT negative’ (hsTnT was <0.014 mcg/mL), ‘new positive’ (hsTnT was ≥0.014 mcg/mL and cTnT <0.03 mcg/mL) and ‘TnT positive’ (cTNT was ≥0.03 mcg/mL).Results: Positive results more than doubled with the hsTnT assay (50% vs 22%, P < 0.001). 81 patients were ‘TnT negative’, 44 were ‘new positive’ and 36 ‘cTnT positive’. The discharge diagnosis for ‘new positives’ was AMI in 4 (9%), other cardiac in 13 (30%) and non‐cardiac in 27 (61%). At 90 days adverse events occurred in 30%, 54% and 50% of the groups respectively. There were no late cases of AMI or cardiovascular death in ‘new positive’ patients.Conclusion: Many patients with diagnoses other than AMI will have hsTNT above the reference level. Indiscriminate testing with hsTnT might lead to more patients requiring serial troponin testing and/or invasive further tests, which will have process and resource implications for EDs and health services.
Retrospective study of outcome following desmotomy of the accessory ligament of the deep digital flexor tendon for type 1 flexural deformity in Thoroughbreds
Authors: Walmsley EA , Anderson GA , Adkins AR 
Published: June 2011

Objective Determine the long‐term outcome for Thoroughbreds undergoing desmotomy of the accessory ligament of the deep digital flexor tendon (DAL‐DDFT) for type 1 flexural deformity of the distal interphalangeal joint (DIPJ).Design Retrospective matched cohort studyProcedure Medical records were retrieved over a 17‐year period for Thoroughbreds that underwent DAL‐DDFT for type 1 flexural deformity. Long‐term outcome was determined by analysis of race records and comparison with maternal siblings. Comparisons between cases and controls included 2‐year‐old, 3‐year‐old and total career performance data.Results There were 46 cases of DAL‐DDFT. The mean age at surgery was 151 days (median 118, range 2–562); 48% of case horses and 77% of 90 controls started in a race. For case horses that did race, the time to first race, total number of starts and prize money per race were not significantly different to maternal siblings. Age at the time of surgery did not alter the likelihood of starting a race.Conclusion Thoroughbreds undergoing DAL‐DDFT for type 1 flexural deformity of the DIPJ are less likely to race when compared with their maternal siblings. For those that do race, the time to first race, total races and earnings per race are not different from controls. There is no evidence to suggest that age at the time of surgery influences the likelihood of racing.
Lethal genetic disorder in Poll Merino/Merino sheep in Australia
Authors: Shariflou MR , Wade CM , Windsor PA , Tammen I , James JW , Nicholas FW 
Published: June 2011

Objectives  Characterise a lethal genetic disorder in Poll Merino/Merino sheepDesign  Pathological description of a new congenital multisystem disorder in a commercial sheep flock, and analysis of breeding data collected each lambing season between 2004 and mid‐lambing season 2010.Procedure  Necropsies were conducted on six affected lambs and the mode of inheritance of the disorder was determined by pedigree and segregation analyses.Results  The affected lambs were dwarfs with multiple defects in several organs, including skeleton, heart, liver and kidneys. The disorder has been named brachygnathia, cardiomegaly and renal hypoplasia syndrome (BCRHS). Segregation analysis suggests the disorder is transmitted as an autosomal trait with a recessive mode of inheritance. An annual incidence of the disorder in the discovery flock of up to 2.5% was recorded.Conclusions  As a lethal disorder, the occurrence of BCRHS raises potential ethical and economic concerns for Merino breeders. The development of a DNA test would be useful to investigate its distribution in the Australian wool‐sheep population. As the disorder affects both the skeleton and several critical organs, including the heart, it may provide a potential animal model for investigating key developmental processes in humans and other animals.
Ore Geology, Fluid Inclusion, and S‐ and Pb‐Isotopic Constraints on the Genesis of the Chitudian Zn‐Pb Deposit, Southern Margin of the North China Craton
Authors: DUAN Shigang , XUE Chunji , CHI Guoxiang , LIU Guoyin , YAN Changhai , FENG Qiwei , SONG Yaowu 
Published: June 2011

AbstractThe Chitudian Zn‐Pb ore deposit, Luanchuan, Henan province, was recently discovered in the southern margin of the North China Craton. The Zn‐Pb orebodies are hosted in the Proterozoic Guandaokou and Luanchuan Groups, occurring as veins in interbedding fracture zones mainly in a WNW‐ and partially in a NS‐direction. The Zn‐Pb ores are characterized by banded, massive, and breccia structures, coarse crystal grains, and a simple mineral composition mainly of galena, sphalerite, pyrite, quartz, dolomite, and calcite. In addition to the vein type orebodies, there are Mo‐ and Zn‐bearing skarn orebodies in the northwest of the Chitudian ore field. Four types of primary fluid inclusions in quartz and calcite were recognized in the Chitudian Zn‐Pb ores, including aqueous, aqueous‐CO2, daughter‐mineral‐bearing aqueous, and daughter‐mineral‐bearing aqueous‐CO2 inclusions, with aqueous inclusion being most common. The homogenization temperatures of the fluid inclusions from the main mineralization stage are from 290°C to 340°C, and the salinities mainly from 3.7 to 14.8 wt% NaCl equivalent. In addition to CO2, CH4 and H2S were detected in the vapor phase and HS‐ in the liquid phase of the fluid inclusions by Laser Raman spectroscopy. The δ34SV‐CDT values of ore sulfides from the Chitudian deposit range from −0.32‰ to 8.30‰, and show two modal peaks in the histogram, one from 1‰ to 4‰, and the other from 5‰ to 7‰. The former peak is similar to that of porphyry‐type Mo‐W deposits in the area, whereas the latter is relatively close to the sulfur in the strata. The ore sulfur may have been derived from both the magma and the strata. The Pb‐isotopic compositions of the ore minerals from Chitudian, with 206Pb/204Pb from 17.005 to l7.953, 207Pb/204Pb from 15.414 to 15.587, and 208Pb/204Pb from 37.948 to 39.036, are similar to those of Mesozoic porphyries in the Chitudian ore field, suggesting that the ore‐forming metals were mainly derived from the Mesozoic magmatic intrusions. The Chitudian Zn‐Pb deposit is interpreted to be a distal hydrothermal vein‐type deposit, which was genetically related to the proximal, skarn‐type Mo ore deposits in the region.
Geology, Fluid Inclusion, and Sulfur Isotope Studies of the Chehugou Porphyry Molybdenum–Copper Deposit, Xilamulun Metallogenic Belt, NE China
Authors: ZENG Qingdong , LIU Jianming , ZHANG Zuolun , ZHANG Weiqing , CHU Shaoxiong , ZHANG Song , WANG Zaicong , DUAN Xiaoxia 
Published: June 2011

AbstractThe Chehugou Mo–Cu deposit, located 56 km west of Chifeng, NE China, is hosted by Triassic granite porphyry. Molybdenite–chalcopyrite mineralization of the deposit mainly occurs as veinlets in stockwork ore and dissemination in breccia ore, and two ore‐bearing quartz veins crop out to the south of the granite porphyry stock. Based on crosscutting relationships and mineral paragenesis, three hydrothermal stages are identified: (i) quartz–pyrite–molybdenite ± chalcopyrite stage; (ii) pyrite–quartz ± sphalerite stage; and (iii) quartz–calcite ± pyrite ± fluorite stage. Three types of fluid inclusions in the stockwork and breccia ore are recognized: LV, two‐phase aqueous inclusions (liquid‐rich); LVS, three‐phase liquid, vapor, and salt daughter crystal inclusions; and VL, two‐phase aqueous inclusions (gas‐rich). LV and LVS fluid inclusions are recognized in vein ore. Microthermometric investigation of the three types of fluid inclusions in hydrothermal quartz from the stockwork, breccia, and vein ores shows salinities from 1.57 to 66.75 wt% NaCl equivalents, with homogenization temperatures varying from 114°C to 550°C. The temperature changed from 282–550°C, 220–318°C to 114–243°C from the first stage to the third stage. The homogenization temperatures and salinity of the LV, LVS and VL inclusions are 114–442°C and 1.57–14.25 wt% NaCl equivalent, 301–550°C and 31.01–66.75 wt% NaCl equivalent, 286–420°C and 4.65–11.1 wt% NaCl equivalent, respectively. The VL inclusions coexist with the LV and LVS, which homogenize at the similar temperature. The above evidence shows that fluid‐boiling occurred in the ore‐forming stage. δ34S values of sulfide from three type ores change from −0.61‰ to 0.86‰. These δ34S values of sulfide are similar to δ34S values of typical magmatic sulfide sulfur (c. 0‰), suggesting that ore‐forming materials are magmatic in origin.
Cobalt‐Bearing Grunerite in the Metamorphosed Banded Iron Formation in Orissa, India
Authors: NAYAK Prasanta Kumar , MOHAPATRA Birendra Kumar , SINGH Prem Prakash , MARTHA Ranjit Kumar 
Published: June 2011

AbstractBanded iron formation (BIF) comprising high grade iron ore are exposed in Gorumahisani‐Sulaipat‐Badampahar belt in the east of North Orissa Craton, India. The ores are multiply deformed and metamorphosed to amphibolite facies. The mineral assemblage in the BIF comprises grunerite, magnetite/martite/goethite and quartz. Relict carbonate phases are sometimes noticed within thick iron mesobands. Grunerite crystals exhibit needles to fibrous lamellae and platy form or often sheaf‐like aggregates in linear and radial arrangement. Accicular grunerite also occur within intergranular space of magnetite/martite. Grunerite needles/accicules show higher reflectivity in chert mesoband and matching reflectance with that of adjacent magnetite/martite in iron mesoband. Some grunerite lamellae sinter into micron size magnetite platelets. This grunerite has high ferrous oxide and cobalt oxide content but is low in Mg‐ and Mn‐oxide compared to the ones, reported from BIFs, of Western Australia, Nigeria, France, USA and Quebec. The protolith of this BIF is considered to be carbonate containing sediments, with high concentrations of Fe and Si but lower contents of cobalt and chromium ± Mg, Mn and Ni. During submarine weathering quartz, sheet silicate (greenalite) and Fe‐Co‐Cr (Mg‐Mn‐Ni)‐carbonate solid solution were formed. At the outset of the regional metamorphic episode grunerite, euhedral magnetite and recrystalized quartz were developed. Magnetite was grown at the expense of carbonate and later martitized under post‐metamorphic conditions. With the increasing grade of metamorphism greenalite transformed to grunerite.
Variation of Rhenium Contents in Molybdenites from the Sar Cheshmeh Porphyry Cu‐Mo Deposit in Iran
Authors: AMINZADEH Balandeh , SHAHABPOUR Jamshid , MAGHAMI Majid 
Published: June 2011

AbstractThis paper presents the results of a study on the variation of Re in the Sar Cheshmeh porphyry copper‐molybdenum deposit in Iran. The Re content was determined in monomineralic molybdenite separates from veinlets and from molybdenum milled floatation concentrates. Mineralogical data and chemical analyses indicate two generations of veinlet molybdenites in the Sar Cheshmeh deposit. The first generation (molybdenite I), which contains low Re, is found as intergrowth with quartz in silicified rocks with low total sulfide content, and the second generation (molybdenite II), which contains high Re, is found in veinlets with low quartz content. There is a positive correlation between the elevation of molybdenite deposition and Re content. Decrease in the temperature and pH of the hydrothermal fluids are effective for the accumulation Re in molybdenite. X‐ray diffraction study of 14 molybdenite samples indicate that the molybdenites are of the 2H polytype.
Advances in diagnostic imaging of the larynx and pharynx
Authors: Garrett K. S. 
Published: June 2011

SummaryImaging of the larynx and pharynx has traditionally been limited to upper airway endoscopy and radiography. Recently, ultrasonography, magnetic resonance imaging and computed tomography have become used more widely. These modalities have increased our diagnostic yield when investigating disorders of the upper airway. The Case Report in this issue (Koenig et al. 2012) describes the diagnosis and biopsy of a laryngeal mass using ultrasonography illustrating one novel application of laryngeal ultrasonography. Increased use of laryngeal ultrasonography and advanced imaging of the larynx and pharynx will hopefully lead to a better understanding of conditions of the upper airway and improved treatment strategies.
The timeline of metalloprotease events during oligofructose induced equine laminitis development
Authors: VISSER M. B. , POLLITT C. C. 
Published: June 2011

SummaryReason for performing study: The role of matrix metalloproteases (MMPs) and the timeline of proteolysis during laminitis development are incompletely understood.Objectives: To determine the temporal progression of selected MMPs and protease regulators during laminitis development.Methods: Five clinically normal Standardbred horses received, via nasogastric intubation, an oligofructose (OF) bolus (10 g/kg bwt). Laminitis induction proceeded for 48 h followed by euthanasia. Lamellar biopsies were obtained prior to dosing and at intervals during the treatment period for analysis (12, 18, 24, 30 and 36 h and at 48 h following euthanasia). Tissue samples were analysed by real‐time PCR, zymography and western blotting.Results: Activation of proMMP‐2 occurs either simultaneously or at least 12 h following lamellar basement membrane (BM) damage, while no activation of proMMP‐9 is seen during OF laminitis induction. Aggrecanase gene expression increased initially at 12–18 h post OF dosing, similar to BM changes. Gene expression of TIMP‐2, a MMP regulator, decreases during laminitis development.Conclusions: The MMP‐2/MT1‐MMP complex may not play a major role in initiating lamellar BM damage. Aggrecanase and TIMP‐2 gene expression appear related to BM lamellar changes.Potential relevance: MMPs, historically thought to cause laminitis, do not appear to play an initiating role in the lamellar lesion. Other host derived proteases and degradation of alternative lamellar matrix components need to be considered.
Increased plasma fructosamine concentrations in laminitic horses
Authors: KNOWLES E. J. , WITHERS J. M. , MAIR T. S. 
Published: June 2011

SummaryReasons for performing study:The use of plasma fructosamine concentration ([fructosamine]) as a marker of abnormal glucose homeostasis in laminitic horses has not been investigated.Hypothesis:Plasma fructosamine concentration may be higher amongst laminitic horses than normal horses; this might relate to underlying insulin resistance.Objectives:1) To compare [fructosamine] between laminitic and normal horses. 2) To investigate associations between [fructosamine] at presentation in laminitic horses with a) single sample markers of insulin resistance and b) outcome.Methods:Plasma fructosamine concentration, fasting serum insulin concentration (insulin) and fasting plasma glucose concentration (glucose) were measured in 30 horses that presented with laminitis. Clinical details and follow‐up data were recorded. Plasma fructosamine concentration was also measured in 19 nonlaminitic control horses.Results:Laminitic horses had significantly higher mean [fructosamine] than normal horses (P<0.001). Thirteen of 30 laminitic horses had fasting hyperinsulinaemia, 2/30 had fasting hyperglycaemia. Statistically significant univariable correlations were identified between [fructosamine] and [glucose], [insulin] and the proxies RISQI and MIRG. Trends for association between [fructosamine] and negative outcome did not reach statistical significance.Conclusions and potential relevance:Increased mean [fructosamine] in laminitic horses may represent abnormal glycaemic control and [fructosamine] may become a clinically useful marker.
Inhibitory effects of sertraline in rat isolated perfused kidneys and in isolated ring preparations of rat arteries
Authors: Fonseca-Magalhães Patrícia A , Sousa Daniel F , de Siqueira Rodrigo J B , Jorge Roberta J B , Meneses Gdayllon C , Alves Renata S , Monteiro Helena S A , Magalhães Pedro J C , Martins Alice M C 
Published: June 2011

Abstract

Objectives
Sertraline is often prescribed to patients suffering with end stage renal disease, but its action on kidney has not been investigated. We aimed to investigate the pharmacological action of sertraline on rat kidney with emphasis on the underlying mechanisms involved in the vascular actions of the drug.

Methods
The effects of sertraline were evaluated in rat isolated perfused kidneys and on ring preparations of mesenteric or segmental rat renal artery.

Key findings
In kidneys, sertraline prevented the effects of phenylephrine on perfusion pressure, glomerular filtration rate, urinary flow and renal vascular resistance. In mesenteric rings sertraline inhibited phenylephrine-induced contractions with potency 30-times lower than verapamil. Sertraline reversed sustained contractions induced by phenylephrine or 60 mm K+ within a similar concentration range. In segmental isolated rings, sertraline also reversed contractions induced by phenylephrine or 60 mm K+ with the same concentration range, but with higher potency compared with mesenteric preparations. Under Ca2+-free conditions, sertraline did not change the intracellularly-mediated phasic contractions induced by phenylephrine or caffeine. Sertraline was ineffective against contractions induced by extracellular Ca2+ restoration after thapsigargin treatment and Ca2+ store depletion with phenylephrine. Conversely, sertraline decreased the contractions induced by Ca2+ addition in tissues under high K+ solution or phenylephrine plus verapamil.

Conclusions
In rat isolated kidneys and in rat ring preparations of mesenteric or renal vessels, sertraline had antispasmodic effects that appeared to be caused by a direct action on vascular smooth muscle cells. Its actions were ineffective against Ca2+-releasing intracellular pathways, but appeared to interfere with sarcolemmal Ca2+ influx with reduced permeability of both receptor- and voltage-gated Ca2+ channels.
Multisite Comparison of High-Sensitivity Multiplex Cytokine Assays
Authors: Breen Elizabeth Crabb , Reynolds Sandra M. , Cox Christopher , Jacobson Lisa P. , Magpantay Larry , Mulder Candice B. , Dibben Oliver , Margolick Joseph B. , Bream Jay H. , Sambrano Elise , Martínez-Maza Otoniel , Sinclair Elizabeth , Borrow Persephone , Landay Alan L. , Rinaldo Charles R. , Norris Philip J. 
Published: June 2011

ABSTRACT

The concentrations of cytokines in human serum and plasma can provide valuable information about
in vivo
immune status, but low concentrations often require high-sensitivity assays to permit detection. The recent development of multiplex assays, which can measure multiple cytokines in one small sample, holds great promise, especially for studies in which limited volumes of stored serum or plasma are available. Four high-sensitivity cytokine multiplex assays on a Luminex (Bio-Rad, BioSource, Linco) or electrochemiluminescence (Meso Scale Discovery) platform were evaluated for their ability to detect circulating concentrations of 13 cytokines, as well as for laboratory and lot variability. Assays were performed in six different laboratories utilizing archived serum from HIV-uninfected and -infected subjects from the Multicenter AIDS Cohort Study (MACS) and the Women's Interagency HIV Study (WIHS) and commercial plasma samples spanning initial HIV viremia. In a majority of serum samples, interleukin-6 (IL-6), IL-8, IL-10, and tumor necrosis factor alpha were detectable with at least three kits, while IL-1β was clearly detected with only one kit. No single multiplex panel detected all cytokines, and there were highly significant differences (
P
< 0.001) between laboratories and/or lots with all kits. Nevertheless, the kits generally detected similar patterns of cytokine perturbation during primary HIV viremia. This multisite comparison suggests that current multiplex assays vary in their ability to measure serum and/or plasma concentrations of cytokines and may not be sufficiently reproducible for repeated determinations over a long-term study or in multiple laboratories but may be useful for longitudinal studies in which relative, rather than absolute, changes in cytokines are important.