bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel dual pH-responsive CMC/OHA/SA antibacterial hydrogel
Authors: Xiao Jiajun , Liang Yanming , Sun Ting , Liu Ming , he xiaoning 
Published: June 2024

Abstract

Background
Within the clinical realm, the complexities of wound healing have consistently presented formidable challenges. Recent advancements, notably in hydrogel technologies, have broadened the therapeutic spectrum. This study focuses on introducing a novel dual pH-responsive composite hydrogel for wound healing. This hydrogel is ingeniously designed to maintain an optimal moist environment, expedite healing, and combat bacterial infection during wound recovery.
Methods
This study presents a new polysaccharide hydrogel formulation, combining carboxymethyl chitosan (CMC), oxidized hyaluronic acid (OHA), and sodium alginate (SA) and incorporating the antibiotic tobramycin (TOB) to create the antibacterial hydrogel CMC-OHA-SA-TOB. Hydrogel cross-linking was verified using infrared spectroscopy, and the microstructure was examined with scanning electron microscopy. We explored its swelling and degradation behaviors in different pH environments. The drug release profile was determined, and biocompatibility was evaluated via cytotoxicity and hemolysis assays. The hydrogel's antibacterial efficacy was tested in both solid and liquid media. Additionally, Sprague–Dawley (SD) rat wound models were employed to investigate the hydrogel's wound healing capabilities in vivo.
Results
The experimental outcomes reveal that the CMC-OHA-SA-TOB hydrogel was effectively cross-linked, forming a network structure. The hydrogel exhibited pronounced responsiveness in its swelling and degradation characteristics, significantly influenced by variations in pH levels. In vitro assessments demonstrated that the CMC-OHA-SA-TOB hydrogel exhibits limited cytotoxicity and hemolysis, coupled with a pH-responsive drug release profile. Sustained antibacterial activity of the hydrogel against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli was confirmed. Furthermore, in vivo experiments underscored the hydrogel's proficiency in promoting wound healing, highlighting its potential for clinical applications.
Conclusions
Consequently, the CMC-OHA-SA-TOB hydrogel not only fosters a moist environment essential for wound healing and enhances structural stability, but it also exhibits functional dual pH-responsive capabilities in swelling and degradation. These distinctive abilities enable the precise release of tobramycin, thereby optimizing wound healing.
Evaluation of sediment transport in primary tributaries of the Yellow River based on RUSLE and SEDD models: A case study of the Wanchuan River Basin
Authors: Liu Xingyu , Li Xiaodan , Zhang Xiaoning , Nian Lili , Lin Zihang , Yang Jiali , Hui Caihong , Zhang Miaomiao , Wu Yingying , Zhao Qiqi , Liu Hongyan , Yang Haiyu , Qu Fei , Lei Jiaojiao , An Yan , Zhang Lide , Wang Lina , Ma Jin , Yang Xuan , Liu Xuelu 
Published: June 2024

Abstract

Soil erosion in the Loess Plateau region has been the most serious ecological problem in Northwest China and even North China. A large amount of soil erosion occurs in the mainstream and tributary areas of the Yellow River, which reduces the soil properties of the basin, increases the amount of sand production and siltation in the water flow, and seriously affects the water quality and ecological environment along the shoreline. The Modified Universal Soil Loss Equation (RUSLE) model is widely used worldwide to simulate soil erosion, and its required data are less demanding to obtain. Meanwhile, in order to improve the practicality of the model and facilitate its use in future work, a combination of RUSLE and sediment delivery ratio (SDR) was used to simulate soil erosion in the watershed. Therefore, the Wanchuan River watershed, a first-class tributary of the Yellow River located in Yuzhong County, Lanzhou City, the capital city of Gansu Province, which is located in the Loess Plateau region, with a large difference between the north and south topographies and a high degree of natural erosion, was selected as the study area in this study. By combining different RUSLE model factors, combining measured data and field sampling data, and using the SEDD model to select the most suitable model construction method for the region, the most suitable factor for estimating the average annual soil loss and sediment transport in the Wanchuan River Basin was selected as a combination of the Craw and the R factors generated by the average annual rainfall. It is hoped that the related research will provide feasible suggestions and theoretical references for soil erosion simulation in the main stream and first-level tributaries of the Yellow River.
Using the received signal strength indicator and machine learning to enhance the security of vehicular ad-hoc networks
Authors: Abdelkreem Eslam , Hussein Sherif , Tammam Ashraf 
Published: June 2024

Abstract

A vehicular Ad-hoc Network (VANET) is a wireless network established between vehicles and surrounding infrastructure to enable information exchange between them. Consequently, many applications that can enhance passengers' security assurance and traffic flow are built upon this information. However, malicious nodes can manipulate the exchanged data to attack other nodes and disrupt the network’s normal behavior. For example, if an attacker broadcasts a falsified vehicle’s location, the functionality of applications that rely on accurate location sharing will be confused, and deadly accidents may occur. Thus, many studies have been conducted to implement Misbehavior Detection Schemes (MDSs) to identify position spoofing attacks in VANET. However, the performance results of these MDSs are limited in detecting some attack types, and most of them rely on application layer features that the attacker can alter before transmission to evade the detection model. So, this paper proposes an MDS for position falsification attack detection that employs a physical-layer-based feature called RSSIConf. The RSSIConf feature relies on the Received Signal Strength Indicator of received messages and its confidence intervals at different confidence levels and distances. The evaluations show that the proposed model outperforms existing approaches, where the improvements range between 0.76% to 13.26% in accuracy and 0.74% to 12.71% in F1-Score, depending on the detected attack type.
Homogeneous Microstructure Improving the Mechanical and Electrochemical Properties of Lead Alloys by Stirring Treatment
Authors: Jiang Cheng , Zhou Yingping , Xu Ruidong , Chen Buming , Huang Hui , Guo Jun , Tao Yi , Gao Chao , Guo Zhongcheng 
Published: June 2024

Abstract

Homogeneous microstructure in lead alloy matrix plays an important role in improving its mechanical and electrochemical properties. In this work, different stirring speed provided during the melt casting of the alloy are tended to obtain lead alloys with different microstructure. The results show that proper stirring speed is beneficial for improving the overall homogeneity of the alloy, however, as the stirring speed is too high, plenty of second phase impurities and defects produced in the lead matrix, which possesses negative effect on the mechanical and electrochemical properties. The most uniform composition and homogeneous microstructure was obtained when the stirring speed is 100 r/min, which is conducive to the decrease of oxygen evolution potential of 30 mV and charge transfer resistance of 22.77%, and the increase of the corrosion resistance of 1.49%, and promote the generation of the uniform and dense PbO2 protective layer.
Analysis of temporal and spatial changes of ecological quality and its influencing factors in Guangdong Province
Authors: Guo Qing , Hou Yu 
Published: June 2024

Abstract

Ecological quality and its influencing factors are important contents of ecological security in Guangdong Province. As the representative of China's high-quality development, maintaining its ecological security is of great significance to China's ecological construction. Based on the remote sensing ecological index (RSEI), this paper analyzes the temporal and spatial changes of ecological quality and its influencing factors in Guangdong Province from 2000 to 2023. According to ENVI and Arcgis software, the spatial and temporal changes of ecological quality in Guangdong Province and the spatial correlation of RSEI in Guangdong Province are calculated and drawn. At the same time, R2 of OLS and MGWR models is fitted to verify the linear fitting relationship between influencing factors and RSEI in Guangdong Province. The research results show that: (1) the development of RSEI in Guangdong Province generally shows a downward trend from 2000 to 2023; (2) The change trend of RSEI in Guangdong Province is different in different periods; (3) The RSEI in Guangdong Province shows strong spatial auto-correlation; (4) The relationship between potential influencing factors and RSEI is not only positive, but also negative. Based on the above conclusions, the article puts forward corresponding policy suggestions.
Supplementing Inorganic with Organic Nitrogen Sources Augments Microbial Dynamics favoring Yield in Rice Ecosystem
Authors: Deka Nikunja Chandra , Kumari Gayatri , Nath Tankeswar 
Published: June 2024

Abstract

Microorganisms play crucial role in the ecosystem building. Their presence or absence in a particular environment are indicative of the web of interactions they undergo to impact the life of other components of the system. The current experiment was undertaken in rice-rice cropping sequence to understand the changes in composition of microorganism as a result of interaction of herbicide and different nutrient sources added to soil under lowland area. The experiment was divided into two simultaneous studies, i.e. field experiment and metagenomic study, to obtain the rice yield and soil microbial dynamics, respectively. Pooled soil samples were collected from rice field with constant herbicide application, i.e. Pyraszosulfuron (pre-emergent) @25g/ha + 2, 4-D (post-emergent @0.5 kg/ha), but with 5 different sources of nutrients, viz, T0- absolute control, T1- 100% N-P2O5-K2O through inorganic fertilizers (recommended dose of 40-20-20 kg/ha)), T2- 75% N through inorganic + 25% N through FYM (P2O5 & K2O recommended doses), T3- 75% N through inorganic + 25% N through vermicompost (P2O5 & K2O recommended doses) and T4- 75% N through inorganic + 25% N through crop residues and bio-fertilizer (P2O5 & K2O recommended doses). Based on the amplicon DNA sequencing approach, it was observed that though there was overall increase in bacterial phyla, viz., Chloroflexi, Actinomycetes, Euryarchaeota, Firmicutes in all the treatments from 0 days after transplanting (DAT) to physiological maturity of plant, where, soil treated with vermicompost (TH3) showed a dramatic increase in the population of Firmicutes. Amongst fungal populations, Actinomycetes increased in all the soils from 0 DAS to physiological maturity, the increase was lowest in soil treated with vermicompost while it was highest in soil having crop residues (T4). The results were concomitant to the biological yield of rice that was observed highest in the soil treated with vermicompost along with inorganic fertilizers. The results could be attributed to the favourable niche provided by vermicompost that resulted in synthesis and release of plant hormones, metabolites and antibiotics by the bacterial population leading to dominance of the bacteria as compared to the other treatments.
Enantioselective formal [4π+2σ] cycloaddition of bicyclobutanes with nitrones enabled by asymmetric Lewis acid catalysis
Authors: Feng Jian-Jun , Wu Wen-Biao , Yang Xue-Chun , Wu Feng , He Heng-Xian , Zhang Xu 
Published: June 2024

Abstract

The absence of catalytic asymmetric methods for synthesizing chiral (hetero)bicyclo[n.1.1]alkanes has hindered their application in new drug discovery. Here we demonstrate the achievability of an asymmetric polar cycloaddition of BCB using a chiral Lewis acid catalyst and a bidentate chelating BCB substrate, as exemplified by the current enantioselective formal [4π+2σ] cycloaddition of BCBs with nitrones. In addition to the diverse BCB incorporating an acyl imidazole group or an acyl pyrazole moiety, a wide array of nitrones are compatible with this Lewis acid catalysis, successfully assembling two congested quaternary carbon centers and a chiral aza-trisubstituted carbon center in the pharmaceutically important hetero-bicyclo[3.1.1]heptane product with up to 99% yield and >99% ee.
Privación del derecho de voto de las personas con discapacidad intelectual. Comentario a la STEDH en el caso de Caamaño Valle c. España (11 de mayo de 2021)
Authors: Sánchez Muñoz Óscar 
Published: June 2024

La cuestión del derecho de voto de las personas con discapacidad intelectual ha recibido una atención merecida en los últimos años[1] que contrasta con la falta de atención o incluso olvido en épocas anteriores. Con anterioridad a la ratificación por España de la Convención Internacional sobre los Derechos de las Personas con Discapacidad (en adelante CDPD), acaecida en 2008, la problemática de este colectivo se consideraba «resuelta» mediante la expeditiva técnica de la inhabilitación para el ejercicio del derecho, ligada a la incapacitación de la persona, la cual era aplicada de forma irreflexiva y casi automática por los órganos judiciales.

[1] Véase la bibliografía citada a lo largo de este comentario.
Enhancing Building Thermal Inertia: Impact of Surface-to-Volume Ratio on Multi-Layered PCM-Integrated Brick Walls
Authors: Necib Hichem 
Published: June 2024

Abstract
In this paper, a numerical study is conducted to investigate the effect of using Phase Change Materials (PCMs) in building bricks to improve the thermal inertia of buildings in hot and dry regions. A numerical model is developed to simulate the heat transfer in a brick with cylindrical holes filled with PCM. The effects of the number, type, and arrangement of PCMs on the thermal performance of the brick are investigated. The results show that the use of PCMs can significantly reduce the heat flux through the brick. The optimal number of PCMs is found to be three layers. The optimal type of PCM for the first layer is n-Eicosane, for the second layer is Paraffin Wax, and for the third layer is n-Octadecane. The enhanced brick configuration, with specific PCM arrangements, reduced total heat flux by up to 71.53% in the simulation period, compared to a brick without PCM.
Prerequisites for Business Development in South-Eastern Europe in the Conditions of Polycrisis and Digital Transformation
Authors: Hristozov Yanko , Nozharov Shteryo 
Published: June 2024

Abstract
Purpose: The purpose of the present study is to identify prerequisites for business development in the conditions of polycrisis in the EU member states of South-Eastern Europe. In the context of digital transformation and the low-carbon transition, this can have an impact on changing their economic policy.
Design/Methodology/Approach: The object of research are selected macroeconomic performance indicators of selected EU member states from Southeast Europe (Bulgaria, Romania, Croatia), which are key their business development. The subject is the determination for the business development in conditions of polycrisis and digital transformation. Methodology is mainly based on descriptive analysis and statistical analysis. The main hypothesis proves the statement that in the conditions of polycrisis in the studied period between 2018 and 2022, the three SEE countries (Bulgaria, Romania and Croatia), underestimate the significance of business development in the field of investments and innovations, reforms and institutional environment, and fiscal policy efficiency.
Findings: Identifying key determinants that respond to exogenous shocks in specific regions of the EU may be useful for changing its fiscal policy and also help countries take measures to create the conditions for business development. Also, it can lead to optimization of corporate management and investment processes.
Prognostic value of pro-inflammatory markers at the preoperative stage in Algerian women with breast cancer
Authors: Zergoun Ahmed Amine , Braikia Syhem , Boubnider Mohsen Wahib , Bouzid Kamel , Touil-Boukoffa Chafia 
Published: June 2024

Abstract

Background
Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), and systemic inflammatory response index (SIRI) are widely used to assess patient’s outcome in many types of neoplasms including breast cancer. The aim of this study was to select the best parameter with a high prognostic value by defining the optimal cutoff value for each parameter in patients undergoing mastectomy.

Patients and Methods
This is a retrospective monocentric study enrolling 59 patients. The receiver operating characteristic (ROC) curve was used for the obtention of the optimal cutoff values of NLR, PLR, MLR, SII, and SIRI. The Kaplan–Meier curve and log-rank test were used to assess recurrence-free survival (RFS), distant metastasis-free survival (DMFS), and overall survival (OS).

Results
Among the five parameters, we obtained the optimal cutoff values for NLR, MLR, SII, and NLR but not for PLR (AUC ≤0.5). To assess the RFS, the optimal cutoff values for NLR, MLR, SII, and SIRI were defined as 2.11, 0.16, 472, and 0.6888, respectively. High MLR (p= 0.0165), SII (p= 0.0368), and SIRI (p= 0.012) were associated to shorter RFS. For DMFS, the optimal cutoff values for NLR, MLR, SII, and SIRI were 1.60, 0.28, 472, and 0.6888, respectively. Interestingly, the Kaplan–Meier curve showed that patients with high MLR (p< 0.0001), SII (p= 0.0345), and SIRI (p= 0.0255) exhibited shorter DMFS.

Conclusions
The MLR, SII, and SIRI indices would be the best indicators. They could constitute a promising predictive tool in the detection of locoregional and distant metastasis.
Immunohistochemical Detection of Axonal Injury in Chimpanzee (Pan troglodytes) with Traumatic and Fatal Brain Injury
Authors: Mohammadzadeh Peyman , Baharvand Ahmadreza , Mohammadi Sajjad , Fooladi Ramin , Azimi Kimia , Eftekhar Erfan 
Published: June 2024

Abstract
Estimating the time of death after traumatic brain injury (TBI) in wildlife is a significant challenge in forensic veterinary medicine. The understanding of histopathological changes and predicting the survival time can prompt critical emergency measures and health management strategies for animals in managed care. Glial fibrillary acidic protein (GFAP) is a well-established astrocytic biomarker for diagnosing, monitoring, and predicting TBI outcomes. Moreover, the buildup of Beta-Amyloid Precursor Protein (βAPP) resulting from axonal damage is an energetic process intricately connected to the survival period following the injury. To date, no study has explored the accumulation of GFAP and βAPP in TBI chimpanzees. In human studies, the earliest reported time for detecting axonal injury postmortem in TBI using βAPP is approximately 30 minutes. This study aimed to investigate whether GFAP and βAPP staining can be used to detect postmortem axonal injury within 30 minutes in TBI chimpanzees. Cerebral and cerebellar tissues from a postmortem TBI chimpanzee and control samples were screened for immunopositivity for GFAP and βAPP in neurons using immunohistochemistry and immunofluorescence. The results suggested that neuronal immunopositivity for GFAP was likely a staining artifact, as negative controls also showed neuronal GFAP staining. However, it was not easy to assume the absence of post-traumatic neuronal GFAP. Conversely, the βAPP assay results indicated that axonal damage can be detected within 22 minutes after death, marking the fastest recorded time to date and aiding in diagnosing severe TBI with short survival times. In conclusion, we demonstrated that the axonal damage in captivated chimpanzee caused by severe and sudden concussion can be detected with βAPP staining within 22 minutes.
An Application of φ-Metric and Related Best Proximity Point Results Generalizing Wardowski’s Fixed Point Theorem
Authors: Das Abhishikta , Som Sumit , Kalita Hemanta , Bag Tarapada 
Published: June 2024

Abstract
In this article, an application of φ-metric is given via a geometrical example to show how it can help to measure distance for non-planar surfaces where the classical metric becomes incapable. We also introduce the concept of best proximity point and proximal contraction for a class of mappings in a φ-metric space and prove a best proximity point theorem for such class of contraction mappings from which the famous “Wardowski’s fixed point theorem” can be deduced as a particular case. To support our theorem, we provide an example in which Wardowski’s metric fixed point theorem cannot be applied.
Experimental Study of the Absorption Coefficient of Acoustic Insulators for Undergraduate University Students
Authors: Macho-Stadler Erica 
Published: June 2024

Objective: This study investigates the techniques for measuring the acoustic absorption coefficient that use an impedance tube, to evaluate their use by students of scientific-technical degrees.

Theoretical Framework: This topic presents the concept of absorption coefficient and how it is obtained using impedance tubes.

Method: The absorption coefficient of an acoustic insulator is measured as a function of frequency, thickness and density, with an experimental system that uses the transfer function method in an impedance tube.

Results and Discussion: The results reveal that the absorption coefficient varies with frequency, being lower at low frequencies. An increase in thickness and/or density produces better acoustic absorption performance. The results are compared with others obtained with an experimental system that uses the standing wave method in an impedance tube. The agreement between the two methods is quite good.

Research Implications: The advantages and disadvantages of the two methods are discussed, and their use by students of scientific-technical degrees is assessed. It is recommended to use the transfer function method when students work more autonomously, for example, in final degree projects.

Originality/Value: This work offers teachers information related to the experimental study of the acoustic absorption coefficient, which allows them to choose the most appropriate method for each student based on their ability to work autonomously and their knowledge.