bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dutch Lutheran Women on the Pulpit
Authors: Hiebsch Sabine 
Published: April 2024

Abstract
In the course of the Twentieth century, the roles for women in Protestant churches in Europe expanded to include the possibility of participating in the church office of minister. For the Evangelical-Lutheran Church in the Kingdom of the Netherlands, the year 2022 marked the centenary of women in the ordained ministry. On June 12, 1922, the Lutheran synod decided that, according to the existing regulations, women could also be admitted as candidates for the ministry. In 1929 Jantine Auguste Haumersen (1881–1967) became the first female Lutheran minister in the Netherlands and worldwide. This made the Lutheran church, after the Mennonites and the Remonstrants, the third denomination in the Netherlands where women could hold the office of minister.
Utilizing a broad cultural analysis and based on recent extensive archival research this article describes the turning points in the development of women’s ordained ministry in the Lutheran Church in the Netherlands.
The Habit Does Make the Monk: Jesuit Dress in the Marianas Mission 1668–1700
Authors: Montón-Subías Sandra 
Published: April 2024

Abstract
This article explores some of the body modifications that occurred in the Mariana Islands during the initial decades of the Jesuit mission. It focuses on Jesuit vestments and the use of Indigenous CHamoru palm-weaving in a cultural background where the CHamoru dress code clashed with Jesuit mindsets. The article also analyzes the imposition of clothing on the CHamorus by the Jesuits and the imposition of nakedness on the Jesuits by the CHamorus as punitive measures within a colonial environment where the Jesuits sought to dismantle traditional lifeways while the CHamorus endeavored to preserve them.
Phenomenology and Critical Hermeneutics of the “Livestock” Industry and Associated Sanctuaries
Authors: Acampora Ralph R. 
Published: April 2024

Abstract
A phenomenology of factory farms and slaughterhouses, as well as associated animal sanctuaries, is mounted. It is found that other animals in the former situations are reified into machine-like beings, as are the workers who deal with them. In terms of critical hermeneutics, it is found that alienation from the process and product of work and from each other and themselves happens for both human and nonhuman denizens of these contexts. In animal sanctuaries, it is found that a contrary movement of “subjectification” occurs. The ethical ramifications of these patterns are that animals become bereft of moral standing in the former institutions and are restored to moral considerability in the latter context.
Newly Identified Fragments of 4Q51 (4QSama)
Authors: Ableman Oren Shalom 
Published: April 2024

Abstract
The following paper is a preliminary publication of newly identified fragments of the book of Samuel that all belong to manuscript 4Q51. The fragments were discovered during the cataloging effort being carried out by the Israel Antiquities Authority (IAA) as part of the digitization project of the Leon Levy Dead Sea Scrolls Digital Library (www.deadseascrolls.org.il). Some of the fragments that will be presented were published in the past, but with various errors. Other fragments have never been published, although due to the placement of some of them on the museum plates it is clear that someone in the past recognized that they belong to 4Q51.
The Peripheral Avant-Garde Artist, Part of and Apart from Europe
Authors: Pinto dos Santos Mariana 
Published: April 2024

Abstract
This article deals with the building of an avant-garde identity in a peripheral European country by returning to a mythical past placed in Egypt. It focuses on the main promoter of Futurism in Portugal, Almada Negreiros, and on how his African roots played a part in the splitting of the self, a phenomenon that at the time was discussed widely in Fernando Pessoa’s circle and which Pessoa himself so dramatically put into practice with the creation of heteronymous identities. It demonstrates how Almada’s heritage was at once an instrument to perform Otherness—that is, a means to construct an identity as civilisation’s Other—and a gateway to accessing the creative origin of all selves through the connecting cipher of ancient Egypt.
Thanatographic Automatism in Michel Leiris’ Aurora (1927–1928)
Authors: Susik Abigail 
Published: April 2024

Abstract
In 1927, Michel Leiris embarked upon a five-month trip to Egypt and Greece. His text Aurora (1927–1928; pub. 1946), commenced during this journey, combines Surrealist approaches with fictional and documentary elements in an investigation of the ontological limits of the writing self. In Aurora, Surrealist automatism and elements of autobiography become epistemological demonstrations of being alive and facing the threat of impending death. Aurora experiments with thanatography, a written account of the death of the self. References to ancient Egyptian necropolis building and hieroglyphics inflect Surrealist automatism with a notion of the self as split between the living voice, death, and the multiplication of consciousness.
Self-Translation in the Sinosphere: Challenging Orthodoxies from Shanghai to Taipei to Makassar
Authors: Cordingley Anthony , Stenberg Josh 
Published: April 2024

Abstract
This article begins a debate in translation studies about the nature of self-translation in the Sinophone world. It demonstrates the continued influence of a history of cosmopolitan authorship and self-translation that emanated from Republican China and moved to Taiwan and beyond in the post-war period. This history and its contemporary effects, including diverse forms of self-translation in Taiwan and Indonesia, are shown to challenge the most prominent models of self-translation, notably those drawing on sociological frameworks such as Abram de Swaan’s “global language system,” which are proven to occlude local realities and multilingual writing. These new perspectives are shown to have consequences for both world literature studies and theoretical accounts of self-translation in the 21st century.
Transposition and Inspiration
Authors: McCraw A. B. 
Published: April 2024

Abstract
Evangelicals have often considered C. S. Lewis’s view of scripture insufficient, viewing several of his statements as directly rejecting the inerrancy of scripture. However, this reading overlooks a foundational theological principle which frames Lewis’s view on scripture—his notion of ‘transposition’. When read in light of this principle, Lewis’s statements on the inspiration of scripture gain greater nuance and resist a strict reading of him as noninerrantist. More, Lewis’s principle of transposition, when applied to scripture, affords space for developing a thick account of inerrancy.
Seven-year outcomes of venetoclax-ibrutinib therapy in mantle cell lymphoma: durable responses and treatment-free remissions
Authors: Handunnetti Sasanka M. , Anderson Mary Ann , Burbury Kate , Thompson Philip A. , Burke Glenda , Bressel Mathias , Di Iulio Juliana , Hicks Rodney J. , Westerman David , Lade Stephen , Pott Christiane , Agarwal Rishu , Koldej Rachel , Ritchie David , Dreyling Martin , Dawson Mark A. , Dawson Sarah-Jane , Seymour John F. , Roberts Andrew W. , Tam Constantine S. 
Published: April 2024

Abstract
In the phase 2 clinical trial (AIM) of venetoclax-ibrutinib, 24 patients with mantle cell lymphoma (MCL; 23 with relapsed/refractory [R/R] disease) received ibrutinib 560 mg and venetoclax 400 mg both once daily. High complete remission (CR) and measurable residual disease negative (MRD-negative) CR rates were previously reported. With median survivor follow-up now exceeding 7 years, we report long-term results. Treatment was initially continuous, with elective treatment interruption (ETI) allowed after protocol amendment for patients in MRD-negative CR. For R/R MCL, the estimated 7-year progression-free survival (PFS) was 30% (95% confidence interval [CI], 14-49; median, 28 months; 95% CI, 13-82) and overall survival (OS) was 43% (95% CI, 23-62; median, 32 months; 95% CI, 15 to not evaluable). Eight patients in MRD-negative CR entered ETI for a median of 58 months (95% CI, 37-79), with 4 experiencing disease recurrence. Two of 3 reattained CR on retreatment. Time-to-treatment failure (TTF), which excluded progression in ETI for those reattaining response, was 39% overall and 68% at 7 years for responders. Beyond 56 weeks, grade ≥3 and serious adverse events were uncommon. Newly emergent or increasing cardiovascular toxicity were not observed beyond 56 weeks. We demonstrate long-term durable responses and acceptable toxicity profile of venetoclax-ibrutinib in R/R MCL and show feasibility of treatment interruption while maintaining ongoing disease control. This trial was registered at www.clinicaltrials.gov as #NCT02471391.
Biology System Description Language (BiSDL): a modeling language for the design of multicellular synthetic biological systems
Authors: Giannantoni Leonardo , Bardini Roberta , Savino Alessandro , Di Carlo Stefano 
Published: April 2024

Abstract
Background
The Biology System Description Language (BiSDL) is an accessible, easy-to-use computational language for multicellular synthetic biology. It allows synthetic biologists to represent spatiality and multi-level cellular dynamics inherent to multicellular designs, filling a gap in the state of the art. Developed for designing and simulating spatial, multicellular synthetic biological systems, BiSDL integrates high-level conceptual design with detailed low-level modeling, fostering collaboration in the Design-Build-Test-Learn cycle. BiSDL descriptions directly compile into Nets-Within-Nets (NWNs) models, offering a unique approach to spatial and hierarchical modeling in biological systems.

Results
BiSDL’s effectiveness is showcased through three case studies on complex multicellular systems: a bacterial consortium, a synthetic morphogen system and a conjugative plasmid transfer process. These studies highlight the BiSDL proficiency in representing spatial interactions and multi-level cellular dynamics. The language facilitates the compilation of conceptual designs into detailed, simulatable models, leveraging the NWNs formalism. This enables intuitive modeling of complex biological systems, making advanced computational tools more accessible to a broader range of researchers.

Conclusions
BiSDL represents a significant step forward in computational languages for synthetic biology, providing a sophisticated yet user-friendly tool for designing and simulating complex biological systems with an emphasis on spatiality and cellular dynamics. Its introduction has the potential to transform research and development in synthetic biology, allowing for deeper insights and novel applications in understanding and manipulating multicellular systems.
OrthoRefine: automated enhancement of prior ortholog identification via synteny
Authors: Ludwig J. , Mrázek J. 
Published: April 2024

Abstract
Background
Identifying orthologs continues to be an early and imperative step in genome analysis but remains a challenging problem. While synteny (conservation of gene order) has previously been used independently and in combination with other methods to identify orthologs, applying synteny in ortholog identification has yet to be automated in a user-friendly manner. This desire for automation and ease-of-use led us to develop OrthoRefine, a standalone program that uses synteny to refine ortholog identification.

Results
We developed OrthoRefine to improve the detection of orthologous genes by implementing a look-around window approach to detect synteny. We tested OrthoRefine in tandem with OrthoFinder, one of the most used software for identification of orthologs in recent years. We evaluated improvements provided by OrthoRefine in several bacterial and a eukaryotic dataset. OrthoRefine efficiently eliminates paralogs from orthologous groups detected by OrthoFinder. Using synteny increased specificity and functional ortholog identification; additionally, analysis of BLAST e-value, phylogenetics, and operon occurrence further supported using synteny for ortholog identification. A comparison of several window sizes suggested that smaller window sizes (eight genes) were generally the most suitable for identifying orthologs via synteny. However, larger windows (30 genes) performed better in datasets containing less closely related genomes. A typical run of OrthoRefine with ~ 10 bacterial genomes can be completed in a few minutes on a regular desktop PC.

Conclusion
OrthoRefine is a simple-to-use, standalone tool that automates the application of synteny to improve ortholog detection. OrthoRefine is particularly efficient in eliminating paralogs from orthologous groups delineated by standard methods.
Effect of metabolically divergent pig breeds and tissues on mesenchymal stem cell expression patterns during adipogenesis
Authors: Ponsuksili Siriluck , Siengdee Puntita , Li Shuaichen , Kriangwanich Wannapimol , Oster Michael , Reyer Henry , Wimmers Klaus 
Published: April 2024

Abstract
Background
Unraveling the intricate and tightly regulated process of adipogenesis, involving coordinated activation of transcription factors and signaling pathways, is essential for addressing obesity and related metabolic disorders. The molecular pathways recruited by mesenchymal stem cells (MSCs) during adipogenesis are also dependent on the different sources of the cells and genetic backgrounds of donors, which contribute to the functional heterogeneity of the stem cells and consequently affect the developmental features and fate of the cells.

Methods
In this study, the alteration of transcripts during differentiation of synovial mesenchymal stem cells (SMSCs) derived from fibrous synovium (FS) and adipose synovial tissue (FP) of two pig breeds differing in growth performance (German Landrace (DL)) and fat deposition (Angeln Saddleback (AS)) was investigated. SMSCs from both tissues and breeds were stimulated to differentiate into adipocytes in vitro and sampled at four time points (day 1, day 4, day 7 and day 14) to obtain transcriptomic data.

Results
We observed numerous signaling pathways related to the cell cycle, cell division, cell migration, or cell proliferation during early stages of adipogenesis. As the differentiation process progresses, cells begin to accumulate intracellular lipid droplets and changes in gene expression patterns in particular of adipocyte-specific markers occur. PI3K-Akt signaling and metabolic pathways changed most during adipogenesis, while p53 signaling and ferroptosis were affected late in adipogenesis. When comparing MSCs from FS and FP, only a limited number of differentially expressed genes (DEGs) and enriched signaling pathways were identified. Metabolic pathways, including fat, energy or amino acid metabolism, were highly enriched in the AS breed SMSCs compared to those of the DL breed, especially at day 7 of adipogenesis, suggesting retention of the characteristic metabolic features of their original source, demonstrating donor memory in culture. In contrast, the DL SMSCs were more enriched in immune signaling pathways.

Conclusions
Our study has provided important insights into the dynamics of adipogenesis and revealed metabolic shifts in SMSCs associated with different cell sources and genetic backgrounds of donors. This emphasises the critical role of metabolic and genetic factors as important indications and criteria for donor stem cell selection.
Gut bacterial and fungal dysbiosis in tuberculosis patients
Authors: Han MeiQing , Wang Xia , Zhang JiaMin , Su Lin , Ishaq Hafiz Muhammad , Li Duan , Cui JunWei , Zhao HuaJie , Yang Fan 
Published: April 2024

Abstract
Background
Recent studies have more focused on gut microbial alteration in tuberculosis (TB) patients. However, no detailed study on gut fungi modification has been reported till now. So, current research explores the characteristics of gut microbiota (bacteria)- and mycobiota (fungi)-dysbiosis in TB patients and also assesses the correlation between the gut microbiome and serum cytokines. It may help to screen the potential diagnostic biomarker for TB.

Results
The results show that the alpha diversity of the gut microbiome (including bacteria and fungi) decreased and altered the gut microbiome composition of TB patients. The bacterial genera Bacteroides and Prevotella were significantly increased, and Blautia and Bifidobacterium decreased in the TB patients group. The fungi genus Saccharomyces was increased while decreased levels of Aspergillus in TB patients. It indicates that gut microbial equilibrium between bacteria and fungi has been altered in TB patients. The fungal-to-bacterial species ratio was significantly decreased, and the bacterial-fungal trans-kingdom interactions have been reduced in TB patients. A set model including Bacteroides, Blautia, Eubacterium_hallii_group, Apiotrichum, Penicillium, and Saccharomyces may provide a better TB diagnostics option than using single bacterial or fungi sets. Also, gut microbial dysbiosis has a strong correlation with the alteration of IL-17 and IFN-γ.

Conclusions
Our results demonstrate that TB patients exhibit the gut bacterial and fungal dysbiosis. In the clinics, some gut microbes may be considered as potential biomarkers for auxiliary TB diagnosis.
Twelve newly assembled jasmine chloroplast genomes: unveiling genomic diversity, phylogenetic relationships and evolutionary patterns among Oleaceae and Jasminum species
Authors: Xu Xiuming , Huang Hechen , Lin Shaoqing , Zhou Linwei , Yi Yuchong , Lin Enwen , Feng Liqing , Zheng Yu , Lin Aiting , Yu Liying , Shen Yingjia , Henry Robert J. , Fang Jingping 
Published: April 2024

Abstract
Background
Jasmine (Jasminum), renowned for its ornamental value and captivating fragrance, has given rise to numerous species and accessions. However, limited knowledge exists regarding the evolutionary relationships among various Jasminum species.

Results
In the present study, we sequenced seven distinct Jasminum species, resulting in the assembly of twelve high-quality complete chloroplast (cp) genomes. Our findings revealed that the size of the 12 cp genomes ranged from 159 to 165 kb and encoded 134–135 genes, including 86–88 protein-coding genes, 38–40 tRNA genes, and 8 rRNA genes. J. nudiflorum exhibited a larger genome size compared to other species, mainly attributed to the elevated number of forward repeats (FRs). Despite the typically conservative nature of chloroplasts, variations in the presence or absence of accD have been observed within J. sambac. The calculation of nucleotide diversity (Pi) values for 19 cp genomes indicated that potential mutation hotspots were more likely to be located in LSC regions than in other regions, particularly in genes ycf2, rbcL, atpE, ndhK, and ndhC (Pi > 0.2). Ka/Ks values revealed strong selection pressure on the genes rps2, atpA, rpoA, rpoC1, and rpl33 when comparing J. sambac with the three most closely related species (J. auriculatum, J. multiflorum, and J. dichotomum). Additionally, SNP identification, along with the results of Structure, PCA, and phylogenetic tree analyses, divided the Jasminum cp genomes into six groups. Notably, J. polyanthum showed gene flow signals from both the G5 group (J. nudiflorum) and the G3 group (J. tortuosum and J. fluminense). Phylogenetic tree analysis reflected that most species from the same genus clustered together with robust support in Oleaceae, strongly supporting the monophyletic nature of cp genomes within the genus Jasminum.

Conclusion
Overall, this study provides comprehensive insights into the genomic composition, variation, and phylogenetic relationships among various Jasminum species. These findings enhance our understanding of the genetic diversity and evolutionary history of Jasminum.
A simple scoring algorithm based on intrinsic capacity for functional ability in community-dwelling older adults in Taiwan
Authors: Chang Ya-Hui , Lin Chung-Ying , Chou Yu-Tsung , Chen Hung-Yu , Su Hui-Chen , Wu Yi-Lin , Yang Yi-Ching , Hou Wen-Hsuan 
Published: April 2024

Abstract
Background
Intrinsic capacity (IC) is a comprehensive indicator of the overall well-being of older adults, and assessing of IC can help identify early stage of disability and tailor intervention to individual needs. However, there is a lack of effective and simple IC assessment tools. This study aimed to establish predictive scoring algorithms of IC to identify older adults at high risk of impaired functional ability.

Methods
We conducted a cross-sectional study in Southern Taiwan, measuring IC using 7 subitems: cognition, locomotion, vitality, vision, hearing, psychological well-being, and medication usage were measured. Functional ability outcomes included frailty, basic activities of daily living, and instrumental activities of daily living (IADL). The capability of 7 domains of IC in predicting functional ability was assessed by multivariable logistic regression. The prediction of capability of scoring algorithms was indicated by receiver operating characteristic (AUC) curves and measures of sensitivity and specificity.

Results
A total of 1,152 older adults were recruited and analyzed. Locomotion emerged as a significant predictor of IADL disability and worsening frailty. The IC-based weighted scoring algorism for predicting IADL demonstrated satisfactory capability (AUC: 0.80), as did the algorithm for predicting worsening frailty (AUC: 0.90). The optimal cutoff points for predicting IADL disability and frailty worse were estimated respectively at 13 and 16, with sensitivity/specificity values of 0.74/0.75 for the IADL prediction algorithm and 0.92/0.77 for the frailty prediction algorithm.

Conclusion
Our 7-domain IC screening tool proves to be sensitive and practical for early identification of functional disability and frailty among community-dwelling older adults in Taiwan.