bluuebunny/crossref_metadata_2025_split huggingface dataset:
Significance of the Corpus Callosum and Inferior Fronto-Occipital Fasciculus in Recovery after Traumatic Brain Injury
Authors: Pogosbekian Eduard L. , Sharova Elena V. , Fadeeva Liudmila M. , Alexandrova Evgenia V. , Chekhonin Ivan V. , Zakharova Natalia E. , Pronin Igor N. 
Published: April 2024

Abstract

Objective: To analyze the correlations between the consciousness state scores and the fractional anisotropy (FA) values in various segments of the Corpus Callosum (CC) and Inferior Fronto-Occipital Fasciculus (IFOF) at different stages of recovery after traumatic brain injury (TBI).
Methods: Diffusion tensor imaging (DTI) was performed in 43 TBI patients and 22 healthy volunteers. The consciousness levels were estimated with the CRS-R scale. The tracts were divided into segments using a template based on tractograms of healthy volunteers, and the correlations between the CRS-R scores and the FA values were calculated for each tract segment.
Results: In the acute period after TBI, 15 segments of the CC and IFOF demonstrated significant correlations (p<0.05). In the long-term period, the highest number (24) of correlations were found in the studied tracts segments. In the subacute period, only 3 segments with correlations were detected.
Conclusions: We propose a new pipeline, which yields spatial localization of correlations between the fractional anisotropy values and the CRS-R scores in patients after TBI. It allows to make assumptions about the functioning of neural networks.
Significance: This work provides new information concerning the organization of fiber tracts and neural networks in TBI patients and may improve neurorehabilitation approaches.
Professional Identity Work of Nurse Practitioners and Family Physicians in Primary Care in Quebec and Ontario – A Study Protocol
Authors: Rodriguez Charo , Archibald Douglas , Grad Roland , Loban Katya , Kilpatrick Kelley 
Published: April 2024

Abstract

Background
Solo medical practices in primary healthcare delivery have been abandoned in favor of interdisciplinary teamwork in most Western countries. Dynamics in interdisciplinary teams might however be particularly difficult when two or more autonomous health professionals develop similar roles at the practice level. This is the case of family physicians (FPs) and nurse practitioners (NPs), due to the fact that the latter might accomplish not only the traditional role proper to a nurse, but also several medical activities such as requesting diagnostic exams and prescribing medical treatments. The tensions that this overlap might generate and their implications in regard of the development of professional identities, and consequently of the quality of health care delivered, have been suggested, but rarely examined empirically. The goal of this study is to examine identity work, i.e., the processes of (re)construction of professional identities, of NPs and FPs working together in primary care interdisciplinary teams.
Methods
A longitudinal, interpretive, and comparative multiple (n = 2) case study is proposed. Identity work theory in organizations is adopted as theoretical perspective. Cases are urban primary care multidisciplinary teams from two different Canadian provinces: Quebec and Ontario. Participants are NPs, FPs, managers, and patients. Data gathering involves audio-diaries, individual semi-structured and focus group interviews, observations, and archival material. Narrative and metaphor techniques are adopted for analyzing data collected. Within- and cross-case analysis will be performed.
Discussion
For practice, the results of this investigation will: (a) be instrumental for clinicians, primary care managers, and policy decision-makers responsible for the implementation of interdisciplinary teamwork in primary healthcare delivery to improve decision-making processes and primary care team performance over time; (b) inform continuing interdisciplinary professional development educational initiatives that support competency in health professionals’ identity construction in interdisciplinary primary care organizations. For research, the project will contribute to enriching theory about identity construction dynamics in health professions, both in the fields of health services and primary care education research.
The extraction method determines the chemical differences between the stem and leaf of Melissa officinalis L.
Authors: Frazão Vitor P. , Hufnagel Mariana T. , Dörr Fabiane , Pessoa Ana Flavia M. , Demarque Daniel Pecoraro 
Published: April 2024

Abstract

In this contribution, we investigate the impact of different extraction methods on the chemical profile of stems and leaves of Melissa officinalis L. Extemporaneous preparations (infusions) were performed and revealed a significant disparity in the chemical profiles of the leaves and stems, with key constituents like rosmarinic acid being notably absent in stem infusions. Subsequent analyses employing sequential maceration with ultrasound and solvents such as hexane, ethyl acetate, and ethanol, however, demonstrated an equivalency of chemical profiles across both plant parts, including the presence of rosmarinic acid. These findings underscore the critical role of extraction methodology in determining the chemical profile of plant-based medicinal preparations.
Identification of Neisseria animaloris infection as the etiology of cardiac tamponade in a cat: a case report
Authors: Mazurek Łukasz , Adaszek Łukasz , Dzięgiel-Michałowska Beata , Michalak Katarzyna , Pietras-Ożga Dorota 
Published: April 2024

Abstract

Background
Cardiac tamponade is a serious problem in companion animals. A diagnosis of COVID-19 too late can lead to death. Neisseria spp. are considered commensal microorganisms of the oral cavity in dogs and cats and are usually isolated from human wounds resulting from bites on these animals.
Case presentation
This article presents a clinical case of a cat with hydropericardium, the cause of which was Neisseria animaloris. Identification of the pathogen in the pericardial sac fluid was performed using the MALDI-TOF method.
Conclusion
This is the first report on a documented case of cardiac tamponade in a cat triggered by Neisseria animaloris bacterial infection in feline medicine, emphasizing its novelty.
Virtual &amp; Mixed Reality Fatigue Scale
Authors: Cintora-Sanz Ana María , Sanchiz-Torres Paula , Blanco-Lara Alberto , Vázquez-Rodríguez Tatiana , Herrador-Sánchez Soledad , Redondo-Lozano María , Cardós-Alonso Carmen 
Published: April 2024

Abstract

Background: Virtual reality (VR) and mixed reality (MR) are effective training tools in different healthcare settings. These tools are useful for preparing emergency health personnel to respond to disasters by providing them with an immersive reality since real practices are very difficult to implement during mass casualty incidents.
Given the usefulness of this approach, assessing the optimal training times associated with this method and the side effects that may influence learning is helpful. One of the most common side effects is fatigue. We developed a scale to assess fatigue in terms of various dimensions that can affect a person while training in the context of VR and MR.
Methods: We designed a questionnaire to assess the fatigue levels perceived by professionals and validated this measure after a VR training experience. We analyzed ratings of visual, mental, physical, and general fatigue. This questionnaire was applied to emergency professionals (n=66).
Results: The reliability and validity of the scale were assessed in terms of the following factors: general, social, emotional, visual, and motivational fatigue.
Conclusions: The results of this research suggest that fatigue is an element of VR training. Educators should take these effects into account to optimize learning in the context of MR.
A spatiotemporal analysis of compound typhoon storm surge disasters in China
Authors: Zhang Suming , Li Xiaomin , Zhang Jie , Du Xuexue , Zhao Tangqi , Hou Yijun 
Published: April 2024

Abstract

The compound typhoon storm surge disaster (CTSSD) is a major Marine disaster in China. Understanding its spatiotemporal characteristics is of great significance for its prevention and mitigation. Characterized by a large spatial scale (China) and a long time series (1989-2020), this paper proposes a framework to investigate the probability and intensity under different compound scenarios. The framework contains two dimensions, time and space, and methods such as the Mann-Kendall test, the Standard Deviation Ellipse model, and the Spatial clustering analysis are adopted. Subsequently, the links between observed characteristics with policy, adaptation, and geography are explored, and suitable risk governance recommendations for Chinese CTSSD are proposed. The results show that the probability characteristics of different compound scenarios are different. This is closely related to the uneven spatiotemporal distribution of precipitation, typhoon landings, and the tide range of astronomical tide, and thus a pattern of "wind and precipitation prevention in South China, and astronomical tide prevention in North China" is proposed. The probability shows an increasing trend but the intensity shows a downward trend, suggesting that policies taken by China (such as building high-standard seawalls, developing technology, and institutional construction) reduce the damage of CTSSD effectively. By understanding the global excellent cases, a suggestion of "use both 'soft' measures and 'hard' measures, develop community-based CTSSD management" is put forward, which is hoped to provide new ideas for the prevention and management of CTSSD in China.
The CTLH Ubiquitin Ligase Substrates ZMYND19 and MKLN1 Negatively Regulate mTORC1 at the Lysosomal Membrane
Authors: Wang Yin , Guo Rui , Piedras Brenda Iturbide , Tang Hsin-Yao , Asara John M. , Tempera Italo , Lieberman Paul M. , Gewurz Benjamin E. 
Published: April 2024

Abstract

Most Epstein–Barr virus-associated gastric carcinoma (EBVaGC) harbor non-silent mutations that activate phosphoinositide 3 kinase (PI3K) to drive downstream metabolic signaling. To gain insights into PI3K/mTOR pathway dysregulation in this context, we performed a human genome-wide CRISPR/Cas9 screen for hits that synergistically blocked EBVaGC proliferation together with the PI3K antagonist alpelisib. Multiple subunits of carboxy terminal to LisH (CTLH) E3 ligase, including the catalytic MAEA subunit, were among top screen hits. CTLH negatively regulates gluconeogenesis in yeast, but not in higher organisms. Instead, we identified that the CTLH substrates MKLN1 and ZMYND19, which highly accumulated upon MAEA knockout, associated with one another and with lysosomes to inhibit mTORC1. ZMYND19/MKLN1 bound Raptor and RagA/C, but rather than perturbing mTORC1 lysosomal recruitment, instead blocked a late stage of its activation, independently of the tuberous sclerosis complex. Thus, CTLH enables cells to rapidly tune mTORC1 activity at the lysosomal membrane via the ubiquitin/proteasome pathway.
An unexpected IgE anti-Receptor binding domain response following natural infection and different types of SARS-CoV-2 vaccines
Authors: Portilho Amanda Izeli , Silva Valéria de Oliveira , Costa Hernan Hermes Monteiro da , Yamashiro Rosemeire , de Oliveira Isabela Penteriche , de Campos Ivana Barros , Prudencio Carlos Roberto , Matsuda Elaine Monteiro , Brígido Luís Fernando de Macedo , De Gaspari Elizabeth 
Published: April 2024

Abstract

The humoral response of SARS-CoV-2 has been studied, primarily focusing on the classical IgG and subclasses. Although IgE antibodies are typically specific to allergens or parasites, a few reports describe its production in response to SARS-CoV-2 and other viruses. Here, we investigated IgE-specific to Receptor Binding Domain (RBD) of SARS-CoV-2 in a Brazilian cohort following natural infection and vaccination. Samples from 59 volunteers were assessed after infection (COVID-19), primary immunization with vectored (ChAdOx1) or inactivated (CoronaVac) vaccines, and booster immunization with mRNA (BNT162b2) vaccine. Natural COVID-19 induced IgE, but vaccination increased its levels. Subjects vaccinated with two doses of ChAdOx1 exhibited a more robust response than those vaccinated with two doses of CoronaVac; however, after boosting with BNT162b2, all groups had similar IgE levels. IgE presented intermediate-to-high avidity, especially after the booster. We also found IgG4 antibodies, mainly after booster, and its levels presented a moderate correlation with IgE. ELISA results were confirmed by controls assays, using IgG depletion by protein G and lack of reactivity with heterologous antigen. In our cohort, no clinical data could be associated with the IgE response. We encourage studies about IgE and its role in immunity, beyond allergies and parasitic infections.
Prevailing Climatic Trends Perspective and Its Impacts on Glaciers in Central Karakoram, South Asia
Authors: Hussain Nasir , Hussain Muhammad , Ullah Sami , Pervez Mahnoor , Nelson Ugwonoh , Ali Baber , Khan Muhammad Nauman 
Published: April 2024

Abstract

In this study climatic variability trends in the Karakoram Mountains range of the Upper Indus Basin (UIB) was studied. The data obtained from two stations including WAPDA (1995–2020) and PMD (1986–2015) were analyzed for mean annual and seasonal trends. Results showed decline in mean seasonal (summer, winter and autumn) minimum and maximum temperature and solar radiation, while increase in temperature observed during the spring season. Moreover, an increase in seasonal precipitation in all seasons and increase in mean maximum and minimum relative humidity were observed in all seasons. The mean thickness of supra glacier debris on Barpu glacier (study glacier) was measured 1–1.5 feet at the study area (ablation zone).Questionnaire study was also conducted to record the indigenous perception. According to the local inhabitants, the rate of retreating of Barpu glacier is slowly and no considerable changes of snout observed during the last two to three decades. It is also confirmed by taking snout coordinates during the year 2013 and 2022, so there is no any fluctuation of snout throughout the study period. Due to decrease in seasonal (summer, winter and autumn) temperature, solar radiation, and increase in summer, autumn and winter precipitation and all seasonal increase relative humidity consequently facilitate the establishment of Karakoram anomaly. Therefore Barpu glacier in central Karakorum shows stable or low melting rate. The glaciers in Karakorum region shows diverse response to global warming as their counterpart elsewhere.
Identification and Field Verification of Fe-Bearing Rocks in the Hasançelebi Region (Malatya, Türkiye) and its vicinity using ASTER and Sentinel-2A images
Authors: İnal Sedat , Kavak Kaan Şevki 
Published: April 2024

Abstract

In this study, image processing applied to ASTER and Sentinel-2A images is used to reveal Fe-bearing rocks in the vicinity of Hasançelebi (Malatya), which is close to Divriği, one of the most important iron provenances in the Central-Eastern Anatolia region of Türkiye. Remote sensing images, particularly the visible-near-infrared (VNIR) and partially shortwave infrared (SWIR) bands, have been employed to identify Fe-bearing minerals and rocks. To achieve this, various band ratioing processes were applied. Supervised classification using a parallelepiped algorithm was employed on the resulting ratio images to create classification distributions for Fe-bearing minerals. Features such as lineaments and faults which play a crucial role in the development of ore deposits were mapped using digital elevation models. During fieldwork, rock samples representing the lithologies and Fe-bearing minerals in the region were collected, and mineralogical-petrographic, geochemical, and XRD analyses were conducted. Additionally, spectral measurements were also taken from the same samples for comparison. These measurements allowed for spectral mineral identification, and spectral signatures were recorded for each sample. Known Fe-bearing minerals are predominantly associated with the Ciritbelen-Otmangölü Fault (COF), which is an approximately east-west trending strike-slip fault in the study area, along with other related fault systems. They are generally distributed within an ophiolitic slice and the surrounding magmatic intrusions. In the image processing and field verifications, it was determined that ASTER images provided more reliable results compared to Sentinel-2A images.
Association of inflammation-related cytokines and immune cells on bladder cancer：A mendelian-randomization study
Authors: Yu Puguang , Wang Huiwei , You Xiangyun , Su Peng , Yang Yanling , Zhang Xiaoli , Dong Dan , Wang Yibing , Wang Kefeng 
Published: April 2024

Abstract

Background
The inflammation-immune response is thought to be closely related to cancer. Although several studies have evaluated the potential prognostic value of inflammation-immune response in cancer over the past few decades, their effects on patients with bladder cancer (BCa) has not been thoroughly reported.
Methods
A two sample mendelian randomization (MR) analysis was performed to analyze the relationship among 91 inflammation-related cytokines, 731 immune cells and BCa in genome-wide association studies. Inverse-variance weighted (IVW) random-effects models were used to examine the relationship between genetic suppression of these exposure factors and BCa risk. Cochran’s Q test, MR-Egger intercept test, and leave-one-out sensitivity analyses were conducted to evaluate the heterogeneity, horizontal pleiotropy, and stability of single-nucleotide polymorphisms in BCa.
Results
Based on the results of MR analysis, we identified 4 inflammation-related cytokines (Neurotrophin-3, IL-2Rβ, 5-hydroxytrptamine and E-selectin) that contributed to poorer outcomes in patients with BCa. In addition, there were 17 immune cells that may play a causal role in BCa. Of these, 9 immune cells and their subtypes were associated with an increased risk of BCa, and 8 were negatively associated with BCa risk. These 8 immune cells belong to HLA DR + T cell subtype, which is a beneficial factor in BCa.
Conclusions
Through genome-wide association studies, we discovered the key involvement of inflammation-related cytokines and immune cells in the coordination of the inflammatory-immune response in BCa. We demonstrated a range of cytokines and immune cell populations that can serve not only as important diagnostic indicators for BCa, but also as key targets for the development of new treatment and prevention strategies.
Reactive Keratin: Harnessing the Power of Polymer Solutions Extracted Hydrothermally from Poultry Feathers and Wool for Eco-Friendly Functional Finishes on Polyester Textiles
Authors: Zemljič Lidija Fras , Čolnik Maja , Fakin Darinka , Pušić Tanja , Bračko Vanessa , Glaser Tjaša Kraševac , Škerget Mojca 
Published: April 2024

Abstract

This research showcases the use of hydrothermally extracted solutions from poultry feathers and wool as eco-friendly and versatile textile finishes. These solutions, derived from waste biomass containing the keratin biopolymer, were obtained through environmentally conscious hydrothermal degradation processes. Initially, the study focused on analysing the chemical parameters and properties of both dialysed and non-dialysed solutions extracted from feathers and wool. The investigation tracked primarily the presence of keratin within these solutions. Upon application to polyester textiles as the reference material, the presence of these solutions on the fabric surface was confirmed successfully. A thorough physicochemical analysis of the treated textiles involved various analytical techniques. These encompassed surface composition analysis via X-ray Photoelectron Spectroscopy (XPS) and Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR), assessment of wettability through Contact Angle measurements, determination of surface charge using surface zeta potential, and examination of the thermal and flame-retardant properties via Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA), and calorimetric tests. In addition, the colour, UV radiation transmission and antioxidant activity were evaluated using standard tests. The remarkable effects of the treatment have been observed in the exceptional antioxidative action, fire resistance, UV protection and enhanced hydrophilicity of these innovative multifunctional textiles. This approach holds significant implications across research, economics and society, enriching Material Science by deepening the understanding of materials and their multifaceted properties. Moreover, it promotes resource efficiency, opens new sustainable textile market prospects, and contributes to social impact by supporting environmental sustainability, engaging communities and ensuring health and safety benefits.
Long-term prediction modeling of shallow rockburst with small dataset based on machine learning
Authors: Rao Guozhu , Wan Jiazheng , Huang Qiang , Xie Yangjun , Lai Qiande , Yang Zhihua , Xiang Run , Zhang Laiye , Rao Yunzhang 
Published: April 2024

Abstract

Rockburst present substantial hazards in both deep underground construction and shallow depths, underscoring the critical need for accurate prediction methods. This study addresses this need by collecting and analyzing 69 real datasets of rockburst occurring within a 500m burial depth, which poses challenges due to the dataset's multi-categorized, unbalanced, and small nature. Through a rigorous comparison and screening process involving 11 machine learning algorithms and optimization with KMeansSMOKE oversampling, the Random Forest algorithm emerged as the most optimal choice. Efficient adjustment of hyperparameters was achieved using the Optuna framework. The resulting KMSORF model, which integrates KMeansSMOKE, Optuna, and Random Forest, demonstrated superior performance compared to mainstream models such as GB, XBG, and ET. Application of the model in a tungsten mine and tunnel project showcased its ability to accurately forecast rockburst levels, thereby providing valuable insights for risk management in underground construction. Overall, this study contributes to the advancement of safety measures in underground construction by offering an effective predictive model for rockburst occurrences.