bluuebunny/crossref_metadata_2025_split huggingface dataset:
Crosslinking of electrospun fibrous gelatin scaffolds for apatite mineralization
Authors: Zhao Jin , Zhao Yuping , Guan Qianqian , Tang Gongwen , Zhao Yunhui , Yuan Xiaoyan , Yao Kangde 
Published: July 2010

AbstractFibrous gelatin scaffolds fabricated via electrospinning followed by crosslinking were used as substrates for apatite mineralization. Gelatin macromolecules were confined by their fibers and further restricted by the crosslinked structure while proper flexibility could be attained upon hydration. After 4 or 5 days of mineralization, partially carbonated hydroxyapatite was proved to deposit uniformly on the surface of the fibers. The property of the substrate, such as stiffness of the scaffolds and flexibility of macromolecules chain, was changed by different crosslinking ways. The influences of these properties on the formation of apatite were also investigated. Results showed that a relatively less rigid interface and more flexible chain acquired by glutaraldehyde solution crosslinking seemed to favor the nucleation of minerals and to reduce the size of the inorganic products. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Effect of ambient atmosphere on crosslinking of polysilazanes
Authors: Chavez Ricardo , Ionescu Emanuel , Balan Corneliu , Fasel Claudia , Riedel Ralf 
Published: July 2010

AbstractThe influence of ambient atmosphere on the crosslinking process of two commercially available polysilazanes with different molecular units in the backbone structure (one polysilazane with and one without urea units) was studied at different temperatures using oscillatory rheometry under isothermal conditions. The measurements were performed using cone/plate, plate/plate, and Couette geometries to assess the influence of the contact surface of the samples with air on their crosslinking behavior. The crosslinking process of the investigated polysilazanes in ambient atmosphere was found to occur faster than that in inert atmosphere. DSC and FTIR‐spectroscopic investigations indicate that hydrolysis and polycondensation processes occur in both polysilazanes when crosslinked in air. Interestingly, the effect of moisture was found to be more pronounced in the case of the urea derivative. The evolution of the measured complex viscosity and dynamic moduli supported this finding. Furthermore, the variation of the time derivative of complex viscosity (dη*/dt) emphasizes structural changes during crosslinking of the samples which were ascribed to their contact with the ambient atmosphere. This study emphasizes the high potential of rheometry in investigating the crosslinking behavior of polymers in inert and ambient atmosphere. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Synthesis of polyaniline nanoparticle grafted silica gel and study of its Cr(VI) binding property
Authors: Chowdhury P. , Mondal P. , Roy K. 
Published: July 2010

AbstractPolyaniline nanoparticles have been synthesized through simple micelle technique and then grafted it with silanized silica gel to develop a novel hybrid material. The nanoparticles are characterized by UV‐Vis, TEM, CV, SEM, TGA, DTG, and DSC. Silanization and grafting reactions are evaluated by FTIR and chemical test. The Cr(VI) binding behavior of the composite is studied in various pH of the medium, and both competitive and noncompetitive conditions. The particle size, adsorption capacity, and surface area of the material are found to be 100 nm, 135 mg/g, and 720 m2/g, respectively. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Expression of pheromone biosynthesis activating neuropeptide and its receptor (PBANR) mRNA in adult female Spodoptera exigua (Lepidoptera: Noctuidae)
Authors: Cheng Yunxia , Luo Lizhi , Jiang Xingfu , Zhang Lei , Niu Changying 
Published: July 2010

AbstractThe full‐length cDNA of pheromone biosynthesis activating neuropeptide receptor (PBANR) was cloned from the beet armyworm, Spodoptera exigua (Hübner) (Lepidoptera: Noctuidae); it included an open reading frame of 1,053 bp encoding 350 amino acids. The PBANR of S. exigua (SePBANR) was structurally characteristic of G protein–coupled receptor and its amino acid sequence shared 98% identity with the PBANR of Spodoptera littoralis. Both pheromone biosynthesis activating neuropeptide (PBAN) and PBANR mRNA abundance were measured in the brain‐subesophageal ganglion complex, pheromone gland, ventral nerve cord, and ovary of S. exigua female moths by real‐time RT‐PCR. The abundance of PBAN mRNA in brain‐subesophageal ganglion complex and PBANR mRNA in pheromone gland was significantly greater compared to other tissues, suggesting that the ligand‐receptor relationship of PBAN and PBANR exists quantitatively in S. exigua. Both PBAN and PBANR expression displayed a remarkable diurnal rhythm, for they were low and stable during the photophase (07:00–21:00) and increased markedly during the scotophase (with a maximum abundance at 23:30) in 3‐day‐old female moths. The abundance of PBAN and PBANR increased steadily from the 1st day to the 5th day of the adult female life. The pattern of both diurnal and daily expression of PBAN and PBANR mRNA were coincident with enhanced capacity of sex pheromone release and mating of S. exigua moths during the same period. We infer from these results that pheromone biosynthesis and release in S. exigua is regulated by PBAN via up‐regulating synthesis. © 2010 Wiley Periodicals, Inc.
Vitamin C content in plants is modified by insects and influences susceptibility to herbivory
Authors: Goggin Fiona L. , Avila Carlos A. , Lorence Argelia 
Published: July 2010

AbstractAnalysis of a diverse cross‐sample of plant‐insect interactions suggests that the abundance of vitamin C (L‐ascorbic acid, ascorbate or AsA) in plants influences their susceptibility to insect feeding. These effects may be mediated by AsAs roles as an essential dietary nutrient, as an antioxidant in the insect midgut, or as a substrate for plant‐derived ascorbate oxidase, which can lead to generation of toxic reactive oxygen species. Ascorbate can also influence the efficacy of plant defenses such as myrosinases and tannins, and alter insects' susceptibility to natural enemies. Conversely, herbivores appear to influence both de novo synthesis and redox cycling of AsA in their host plants, thereby potentially altering the nutritional value of crops and their susceptibility to pests. The recent development of genetically modified crops with enhanced AsA content provides both an impetus and a tool set for further studies on the role of AsA in plant‐insect interactions.
General solutions to consistency problems in multiple hypothesis testing
Authors: Zhao Haibing , Wang Bushi , Cui Xinping 
Published: July 2010

AbstractCoherence and consonance are the two important concepts to ensure consistent conclusions drawn from multiple tests. Unlike coherence, consonance of a multiple testing procedure (MTP) has not yet received much attention. Although most of the MTPs used in practice are consonant, cases still exist that dissonant tests have to be used due to their unique advantages, for example, the likelihood ratio tests and sum tests. Consonance adjustments are necessary for such tests to avoid difficulty in interpretation. Moreover, in terms of detecting elementary hypotheses, a consonant test procedure is uniformly more powerful than the corresponding dissonant one. In this paper, several general methods using the partitioning principle to construct (strongly) consonant and strongly coherent MTPs are proposed. As a result, any dissonant (but coherent) multiple level α test can be improved by a consonant one without any cost in terms of inferences on elementary hypotheses.
Photomobile luminescent polymeric materials on the basis of boron and europium chelates
Authors: Karpenko A. A. , Fedorenko E. V. , Mirochnik A. G. 
Published: July 2010

AbstractThe photomechanical effect was found in a polymer composition on the basis of polymethylmethacrylate with embedded molecules of the luminophor incapable to undergo photochemical isomerization (anthracenoylacetonate of boron difluoride and dibenzoylmethanatoeuropiate triethylammonium), unlike other compounds having the above effect. The possibility of the development of a simple upward–downward movement drive on the basis of the above compounds was demonstrated. Copyright © 2010 John Wiley & Sons, Ltd.
Enzymatic activity and thermal stability of metallo proteins in hydrated ionic liquids
Authors: Fujita Kyoko , Ohno Hiroyuki 
Published: July 2010

AbstractHydrated choline dihydrogen phosphate (Hy[ch][dhp]) containing 30 wt% water was investigated as a novel protein solvent. The Hy[ch][dhp] dissolved some metallo proteins (cytochrome c, peroxidase, ascorbate oxidase, azurin, pseudoazurin and fructose dehydrogenase) without any modification. These proteins retained the surroundings of the active site after dissolution in Hy[ch][dhp]. Some metallo proteins were found to retain their activity in the Hy[ch][dhp]. © 2010 Wiley Periodicals, Inc. Biopolymers 93: 1093–1099, 2010.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Mercury(II) promotes the in vitro aggregation of tau fragment corresponding to the second repeat of microtubule‐binding domain: Coordination and conformational transition
Authors: Yang Dan‐Jing , Shi Shuo , Zheng Leng‐Feng , Yao Tian‐Ming , Ji Liang‐Nian 
Published: July 2010

AbstractThe loss of metal homeostasis and the toxic effect of metal ion are important events in neurodegenerative and age‐related diseases, such as Alzheimer's disease (AD). For the first time, we investigated the impacts of mercury(II) ions on the folding and aggregation of Alzheimer's tau fragment R2 (residues 275‐305: VQIIN KKLDL SNVQS KCGSK DNIKH VPGGGS), corresponding to the second repeat unit of the microtubule‐binding domain, which was believed to be pivotal to the biochemical properties of full tau protein. By ThS fluorescence assay and electron microscopy, we found that mercury(II) dramatically promoted heparin‐induced aggregation of R2 at an optimum molar ratio of 1: 2 (metal: protein), and the resulting R2 filaments became smaller. Isothermal titration calorimetry (ITC) experiment revealed that the strong coordination of mercury(II) with R2 was an enthalpy‐controlled, entropy‐decreased thermodynamic process. The exceptionally large magnitude of heat release (ΔH1 = −34.8 Kcal mol−1) suggested that the most possible coordinating site on the R2 peptide chain was the thiol group of cysteine residue (Cys291), and this was further confirmed by a control experiment using Cys291 mutated R2. Circular dichroism spectrum demonstrated that this peptide underwent a significant conformational change from random coil to β‐turn structure upon its binding to mercury(II) ion. This study was undertaken to better understand the mechanism of tau aggregation, and evaluate the possible role of mercury(II) in the pathogenesis of AD. © 2010 Wiley Periodicals, Inc. Biopolymers 93: 1100–1107, 2010.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
A liquid chromatography–tandem mass spectrometry method for the simultaneous quantification of escin Ia and escin Ib in human plasma: application to a pharmacokinetic study after intravenous administration
Authors: Liu Lidong , Wu Xiujun , Wu Dan , Wang Yingwu , Li Pengfei , Sun Yantong , Yang Yan , Gu Jingkai , Cui Yimin 
Published: July 2010

AbstractA rapid and sensitive liquid chromatography–tandem mass spectrometry (LC‐MS/MS) method was developed and validated for simultaneous quantification of escin Ia and escin Ib in human plasma. After a solid‐phase extraction (SPE), the analytes were separated on a Zorbax Extend C18 column by isocratic elution with a mobile phase of methanol–acetonitrile–10 mm ammonium acetate (27:27:46, v/v/v) at a flow rate of 1.0 mL/min and analyzed by mass spectrometry in the positive ion multiple reaction monitoring mode. The precursor to product ion transitions of m/z 1131.8 → 807.6 was used to quantify escin Ia and escin Ib. Good linearity was achieved over a wide range of 2.00–900 ng/mL for escin Ia and 1.50–662 ng/mL for escin Ib. The intra‐ and inter‐day precisions (as relative standard deviation) were less than 11% for each QC level of escin Ia and escin Ib. The accuracies (as relative error) were within ±5.27% for escin Ia and within ±4.07% for escin Ib. The method was successfully employed in a pharmacokinetic study after a single intravenous infusion administration of sodium aescinate injection containing 10 mg escin to each of the 10 healthy volunteers. Copyright © 2010 John Wiley & Sons, Ltd.
The study of the lipophilicity of some aminoalkanol derivatives with anticonvulsant activity
Authors: Waszkielewicz Anna , Szkaradek Natalia , Pękala Elżbieta , Galzarano Fabiola , Marona Henryk 
Published: July 2010

AbstractA series of new (phenoxyethyl)aminoalkanol derivatives were synthesized and evaluated for their anticonvulsant activity. The most promising compound seemed to be (R,S)‐1N‐[(2,6‐dimethyl)phenoxyethyl]amino‐2‐butanol, which displayed anti‐MES activity (in mice, i.p.) with protective index (TD50/ED50) of 5.712, corresponding to that of phenytoin (6.6), carbamazepine (4.9) and valproate (1.7). The lipophilicity of compounds 1–17 exhibiting anticonvulsant activity was investigated. Their lipophilicities (RM0) were determined using reversed‐phase thin‐layer chromatography (RP‐TLC) with a mixture of acetone and water as mobile phases. The partition coefficients of 1–17 (logP) were also calculated using two computer programs (Pallas and ALOGPS) and compared with RM0. The relationship between anticonvulsant activity and lipophilicity of the tested substances was estimated. Copyright © 2010 John Wiley & Sons, Ltd.
Preparation of Bismuth Oxide Quantum Dots and their Photocatalytic Activity in a Homogeneous System
Authors: Zhang Hua , Wu Ping , Li Yan , Liao Lifang , Fang Zheng , Zhong Xinhua 
Published: July 2010

AbstractColloidal oil‐soluble Bi2O3 quantum dots (QDs) are synthesized through an alcoholysis route in organic media. Water‐soluble Bi2O3 QDs are then obtained from the initial oil‐soluble QDs through phase transfer by surface modification with mercaptopropionic acid. X‐ray diffraction and transmission electron microscopy studies show that the crystallinity is enhanced and particles grow larger after phase transfer. The water‐soluble Bi2O3 QDs exhibit excellent photocatalytic activity for the degradation of methyl orange at a wide range of pH values. After several cycles, the Bi2O3 QDs retain high degradation efficiency. Simulation according to the first‐order reaction dynamics indicates that the degradation reaction may follow complicated quasi‐homogeneous photocatalysis.
Does combination of lipid formulation of amphotericin B and echinocandins improve outcome of invasive aspergillosis in hematological malignancy patients?
Authors: Mihu Coralia N. , Kassis Christelle , Ramos Elizabeth R. , Jiang Ying , Hachem Ray Y. , Raad Issam I. 
Published: July 2010

AbstractBACKGROUND:In vitro and in vivo studies suggested that combination of lipid formulation of amphotericin B (L‐AMB) and echinocandins may have a synergistic or additive effect against Aspergillus. Furthermore, clinical studies suggested that this combination may improve response of invasive aspergillosis (IA).METHODS:Between August 1993 and June 2008, the authors identified a total of 159 patients with hematological malignancies who received salvage therapy for IA, with L‐AMB alone, echinocandins alone, or a combination of L‐AMB and echinocandins. Clinical characteristics, response to salvage therapy, and death up to 12 weeks after initiation of salvage therapy were retrospectively determined for all patients.RESULTS:Seventy patients received salvage therapy with L‐AMB, 18 patients received echinocandins alone (89% of whom received caspofungin), and 71 patients received the combination therapy of amphotericin B and echinocandins (90% of who received caspofungin). The 3 salvage treatment groups were comparable in regard to clinical characteristics; graft versus host disease was more frequently encountered in the echinocandin group, whereas more patients in the L‐AMB and combination groups had neutropenia and received immunotherapy. The response to salvage therapy was better in the echinocandin group (9% L‐AMB, 28% echinocandins, and 21% for combination therapy). The 3 groups had a comparable rate of Aspergillus‐related death (58%‐64%) and overall mortality (61%‐67%).CONCLUSIONS:The combination of L‐AMB and echinocandins offered no advantage in terms of improving response or reducing mortality over either drug alone. Hence, this combination will only add to the cost of therapy without any improvement in outcome in patients with hematological malignancies. Cancer 2010. © 2010 American Cancer Society.
Investigation of carrier scattering mechanisms in molybdenum diselenide single crystals by hall effect measurements
Authors: Sumesh C. K. , Patel K. D. , Pathak V. M. , Srivastav R. 
Published: July 2010

AbstractMolybdenum diselenide (MoSe2) belong to the large family of layered transition metal dichalcogenides. It consists of weakly coupled sandwiched layers i.e. Se – Mo – Se in which a Mo atom layer is enclosed within two Se layers. This structure makes MoSe2 extremely anisotropic in character and leads to unusual structural properties. In addition, MoSe2 possess flexible nature along with good carrier mobility to make them potential candidate for fabricating flexible high mobility electronic devices such as Schottky barrier devices, FETs, solar cell etc. In context of this authors made an effort to study the low temperature (12 < T < 300 K) electronic transport properties of Molybdenum diselenide (MoSe2). Through the investigation the temperature dependent Hall mobility study revealed that the grown crystals of MoSe2possess a mixed scattering mechanism. It has been found that observed temperature dependant mobility has at least two transitions from lattice to impurity scatterings showing an imprint of multicarrier nature of this semiconductor originating from its complex band structure. It has been observed that the studied crystals have at least two group of carriers of differing origins in which transition between dominant scattering mechanisms occur at different temperatures. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Modeling and Measurement of Toroidal Currents in the HSX Stellarator
Authors: Schmitt J. C. , Talmadge J. N. , Lore J. 
Published: July 2010

AbstractA set of magnetic diagnostics, including Rogowski coils, diamagnetic loops and two poloidal ‘belts’ of 3‐axis pick‐up coils measure the magnetic field at several locations around HSX. The two belts are separated by ≈1/3 of a field period and measure the local magnetic field vector at 16 poloidal locations at the two toroidal angles. With the VMEC [1] and PENTA [2] codes, a calculation of the Pfirsch‐Schlüter (PS) and bootstrap currents is performed. The 3‐D equilibrium reconstruction code V3FIT [3] is then used to calculate the expected response of the magnetic diagnostics. The sensitivity of the diagnostic set to features in both the PS and bootstrap current is explored. Because of the lack of toroidal curvature, the dipole PS current has a helical rotation and nearly reverses at the two toroidal locations. The bootstrap current in HSX is in the opposite direction compared to that in a tokamak. Compared to a tokamak, the relative magnitude of each current is reduced by a factor of the effective transform (≈3) [4]. The PS current reaches steady state quickly, whereas the bootstrap current rises throughout the discharge on a 50‐500 ms timescale. In most cases, the toroidal current is still rising at the end of the discharge, reaching 0.4‐0.6 kA. A 3‐D model that relies on the calculation of the susceptance matrix [5] is used to calculate the time evolution of the toroidal current (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Influence of the Resonant Magnetic Perturbation on the Plasma Boundary in DIII‐D
Authors: Jakubowski M.W. , Evans T.E. , Fenstermacher M.E. , Lasnier C.J. , Schmitz O. , Wolf R.C. , Baylor L.R. , Boedo J.A. , Burrell K.H. , Frerichs H. , Grassie J.S. de , Gohil P. , Mordijck S. , Moyer R. A. , Leonard A. W. , Reiter D. , Samm U. , Schaffer M. J. , Osborne T. H. , Unterberg E. A. , Watkins J. G. 
Published: July 2010

AbstractStochastic boundaries in fusion devices have been investigated in tokamaks, stellarators and reversed field pinch experiments for many years. However, since edge localized modes (ELMs) have been successfully eliminated in H‐mode plasmas at the DIII‐D tokamak [1,2] with small, edge resonant magnetic perturbations, they have become a widely investigated topic in tokamaks. In DIII‐D stochastic boundaries are produced by coils external to the plasma. The magnetic field there consists of field lines with very different connection lengths, which produces a three dimensional, heterogenous structure of stochastic volume. The most obvious manifestation of the perturbed plasma edge is the strike line splitting observable in heat and particle fluxes, which changes with collisionality. The interaction of the magnetic perturbation and the magnetic equilibrium is of a resonant nature and the structure of the stochastic volume is a strong function of q95. This is observed as a modulation of e.g. electron temperature as measured by ECE or Thomson scattering. In this work we summarize recent experimental findings on properties of the stochastic boundary in DIII‐D (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Loss of Necdin impairs myosin activation and delays cell polarization
Authors: Bush Jason R. , Wevrick Rachel 
Published: July 2010

AbstractNDN is one of several genes inactivated in Prader–Willi syndrome (PWS), a developmental disorder characterized by obesity, hypotonia, and developmental delay. We demonstrate that loss of Necdin in murine and human fibroblasts impairs polarity initiation through a Cdc42‐myosin‐dependent pathway, thereby reducing cell migration. We identified defective polarization in both primary neuron cultures and in the developing limb in Ndn‐null mice. Ndn‐null neurons fail to activate myosin light chain and display defective polarization with respect to a brain‐derived neurotrophic factor gradient. Pax3+ muscle progenitors in Ndn‐null developing forelimbs display defective polarization, do not adequately migrate into the dorsal limb bud, and extensor muscles are consequently smaller. These results provide strong evidence that Necdin is a key protein regulating polarization of the cytoskeleton during development. Furthermore, this is the first demonstration of a cellular defect in PWS and suggests a novel molecular mechanism to explain neurological and muscular pathophysiologies in PWS. genesis 48:540–553, 2010. © 2010 Wiley‐Liss, Inc.