bluuebunny/crossref_metadata_2025_split huggingface dataset:
MARCH5 promotes hepatocellular carcinoma progression by inducing p53 ubiquitination degradation
Authors: Cai Xin , Gao Jie , Yan Zhiping , Zhang Huapeng , Guo Danfeng , Zhang Shuijun 
Published: June 2024

Abstract
Background
Human MARCH5 is a mitochondria-localized E3 ubiquitin-protein ligase that is essential for the regulation of mitochondrial dynamics. A large body of evidence suggests that imbalances in mitochondrial dynamics are strongly associated with cancer. However, the expression, biological function and prognostic significance of MARCH5 in hepatocellular carcinoma (HCC) have not been determined.

Materials and methods
The mRNA and protein expression of MARCH5 in HCC cell lines and tumor tissues was assessed by real-time quantitative PCR, Western blot analysis and immunohistochemistry. The clinical prognostic significance of MARCH5 was evaluated in 135 HCC patients. Knockdown or overexpression of MARCH5 in HCC cells was determined by in vitro cell proliferation, migration and invasion assays, and in vivo tumor growth and metastasis assays. In addition, the intrinsic mechanisms by which MARCH5 regulates HCC cell growth and metastasis were explored.

Results
MARCH5 was significantly overexpressed in HCC cells and was closely associated with patients' poor postoperative prognosis. In vivo and in vitro experiments revealed that MARCH5 significantly promoted the increase and invasive and migratory ability of hepatocellular carcinoma cells, which was mainly due to the promotion of autophagy by MARCH5. Mechanistic studies revealed that MARCH5 promoted autophagy through ubiquitination degradation of p53 leading to malignant progression of hepatocellular carcinoma.

Conclusion
Our findings suggest that MARCH5 plays a critical oncogenic role in HCC cells, which provides experimental evidence for the use of MARCH5 as a potential target for HCC therapy.
Acute kidney injury after colorectal surgery with prophylactic ureteral stents
Authors: Rather Assar , Fisher Adrianne , Gardner Kelly , Ghanem Nessreen , Katsichtis Theodoris , Siegelman Gary , Mannion John D. 
Published: June 2024

Abstract
Background
After colorectal surgery, acute kidney injury (AKI) results from a complex interplay of multiple independent causes and preventive measures that occur during the hospitalization. Prophylactic stenting for ureter identification has been identified as a potential cause, but the evidence is conflicting, possibly because of differing baseline characteristics and procedure-related approaches.

Objective
This retrospective cohort study assesses the role of stents in the etiology of AKI after determining the independent predictors of AKI.

Methods
From a population of 1224 consecutive colorectal patients (from 8/1/2016 through 12/31/2021), 382 (31.2%) received ureteral stents, and propensity score matching was used to create stented and control groups. Emergent cases and patients with sepsis were excluded from the analysis. Previously identified independent predictors of AKI, minimally invasive procedures, and a history of diabetes mellitus were used as criteria to create two balanced groups.

Results
Baseline demographic characteristics and procedure-related factors baseline factors were similar between the groups. There was no difference in the rate of AKI between stented patients and controls (P = 0.82), nor was there any difference in postoperative complications, such as chronic renal insufficiency (CRI, P = 0.49), average postoperative creatinine (P = 0.67), urinary tract infections (UTI, P = 0.82), any postoperative infection (P = 0.48), in-hospital complications (P = 1.00), length of stay (LOS, P = 0.15), and 30-day readmissions (P = 0.79).

Conclusions
In a population of patients where stenting was frequently employed, ureter stents placed for identification did not appear to cause AKI or AKI-related complications.

Graphical Abstract
A finite volume adaptation of beam-to-beam contact interactions implemented for geometrically exact Simo–Reissner beams
Authors: Bali Seevani , Tuković Željko , Cardiff Philip , Ivanković Alojz , Pakrashi Vikram 
Published: June 2024

AbstractThis paper presents an adaption of the finite-element based beam-to-beam contact interactions into a finite volume numerical framework. A previous work of the same authors, where a cell-centred based finite volume implementation of geometrically exact nonlinear Simo–Reissner beams was developed, is used as an underlying mathematical model. An implicit contact procedure is developed for both point-to-point and line-to-line beam frictionless contact interactions, and is implemented using the cell-centred finite volume method. To enforce the contact constraint, both penalty method and augmented-Lagrangian based techniques are used. A total of six numerical benchmark cases for point and line beam-to-beam contact interactions based on the finite element method are used to verify the numerical results, accuracy and robustness of the developed contact procedure.
Proliferative glomerulonephritis with monoclonal IgG deposits in an adolescent successfully treated with daratumumab
Authors: Svabova Eva , Zieg Jakub , Sukova Martina , Flachsova Eva , Kment Martin , Tesar Vladimir 
Published: June 2024

AbstractThere is no specific treatment for proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID), a disease that is very rare in the pediatric population. We report the case of a 15-year-old boy who presented with mildly reduced kidney function and nephrotic syndrome. Kidney biopsy revealed PGNMID with monoclonal deposits of IgG3 with kappa light chain restriction. Flow cytometry showed a significant CD38 plasma cell population in the peripheral blood in the absence of other signs of hematological malignancy. The patient was treated with a 6-month course of daratumumab, a monoclonal antibody targeting CD38. There was a significant reduction in proteinuria and normalization of kidney function. Based on positive experience with adults, daratumumab should also be studied in children with PGNMID.
Assessing the association between quantity and quality of family caregiver participation in decision-making clinical encounters on patient activation in the metastatic breast cancer setting
Authors: Henderson Nicole L. , Padalkar Tanvi , Bourne Garrett , Hendrix Emma K. , Williams Courtney P. , Odom J. Nicholas , Triebel Kristen , Rocque Gabrielle B. 
Published: June 2024

Abstract
Objective
Caregivers support individuals undergoing cancer treatment by assisting with activities, managing care, navigating healthcare systems, and communicating with care teams. We explored the quality and quantity of caregiver participation during recorded decision-making clinical appointments in women with metastatic breast cancer.

Methods
This was a convergent parallel mixed methods study that utilized qualitative and quantitative data collection and analysis. Caregiver participation quality was operationalized using a summative thematic content analysis to identify and sum caregiver actions performed during appointments. Performance of a greater number of actions was considered greater quality of participation. Caregiver participation quantity was measured by calculating the proportion of speaking time. Participation quality and quantity were compared to patient activation, assessed using the Patient Activation Measure 1-month post decision-making appointment.

Results
Fifty-three clinical encounters between patients with MBC, their caregivers, and oncologists were recorded. Identified caregiver actions included: General Support; Management of Treatment or Medication; Treatment History; Decision-Making; Insurance or Money; Pharmacy; Scheduling; Travel Concerns; General Cancer Understanding; Patient Specific Cancer Understanding; Caregiver-Initiated or Emphasis on Symptom Severity; and Caregiver Back-Up of Patient Symptom Description. Caregivers averaged 5 actions (SD 3): 48% of patient’s caregivers had low quality (< 5 actions) and 52% had high quality (> 6 actions) participation. Regarding quantity, caregivers spoke on average for 4% of the encounter, with 60% of caregivers speaking less than 4% of the encounter (low quantity) and 40% of caregivers speaking more than 4% (high quantity). Greater quality and quantity of caregiver participation was associated with greater patient activation.

Conclusions
Caregivers perform a variety of actions during oncological decision-making visits aiding both patient and provider. Greater participation in terms of quantity and quality by the caregiver was associated with greater patient activism, indicating a need for better integration of the caregiver in clinical decision-making environments.
A crossover comparison of patient satisfaction with two teriparatide regimens: primary results of the Japanese Osteoporosis Intervention Trial 06 (JOINT-06)
Authors: Soen Satoshi , Uemura Yukari , Tanaka Shiro , Takeuchi Yasuhiro , Endo Naoto , Takada Junichi , Ikeda Satoshi , Iwamoto Jun , Okimoto Nobukazu , Tanaka Sakae 
Published: June 2024

Abstract
Introduction
This study aimed to compare treatment satisfaction with two dosing regimens (two teriparatide [TPTD] self-injection systems) in osteoporosis patients at high risk of fracture.

Materials and methods
In this open-label crossover randomized trial comparing self-injected once-daily (1/D)-TPTD with self-injected twice-weekly (2/W)-TPTD, three satisfaction variables were evaluated by questionnaire for 2 years. The primary endpoint was overall satisfaction and secondary endpoints were satisfaction with treatment effectiveness and with utility of the self-injection device. Changes in quality of life (QOL) assessed by EuroQol-5 Dimension, pain assessed by visual analogue scale (VAS), and anthropometric parameters were also analyzed. Safety was evaluated based on the incidence and severity of adverse events (AEs).

Results
The 1/D-TPTD and 2/W-TPTD groups consisted of 180 (75.9 ± 7.3 years) and 179 (age: 75.5 ± 6.9 years) patients, respectively. After 26 weeks of treatment, no significant between-group difference in the persistence rate (79.4% vs 72.6% in the 1/D-TPTD and 2/W-TPTD groups, respectively), distributions of overall satisfaction scores, and satisfaction with treatment (p > 0.05) were observed. However, several items of satisfaction with the utility of the injection device were significantly higher in the 2/W-TPTD group (p < 0.05). Statistical improvements from baseline values were observed in QOL and pain VAS in both groups (p < 0.05). No serious AEs were reported.

Conclusion
The between-group similarity of overall treatment satisfaction and effectiveness scores and between-group difference in satisfaction with the utility of the self-injection device was useful information for real-world treatment of osteoporosis. Both medication regimens were well tolerated.
Audience perceptions of Foley footsteps and 3D realism designed to convey walker characteristics
Authors: Cunningham Stuart , McGregor Iain 
Published: June 2024

AbstractFoley artistry is an essential part of the audio post-production process for film, television, games, and animation. By extension, it is as crucial in emergent media such as virtual, mixed, and augmented reality. Footsteps are a core activity that a Foley artist must undertake and convey information about the characters and environment presented on-screen. This study sought to identify if characteristics of age, gender, weight, health, and confidence could be conveyed, using sounds created by a professional Foley artist, in three different 3D humanoid models, following a single walk cycle. An experiment was conducted with human participants (n=100) and found that Foley manipulations could convey all the intended characteristics with varying degrees of contextual success. It was shown that the abstract 3D models were capable of communicating characteristics of age, gender, and weight. A discussion of the literature and inspection of related audio features with the Foley clips suggest signal parameters of frequency, envelope, and novelty may be a subset of markers of those perceived characteristics. The findings are relevant to researchers and practitioners in linear and interactive media and demonstrate mechanisms by which Foley can contribute useful information and concepts about on-screen characters.
Viewpoint-sharing method with reduced motion sickness in object-based VR/AR collaborative virtual environment
Authors: Tserenchimed Tuvshintulga , Kim Hyungki 
Published: June 2024

AbstractWe propose a viewpoint-sharing method with reduced motion sickness in an object-based remote collaborative virtual environment (CVE). The method is designed with an assumption of asymmetric, object-based CVE where collaborators use non-homogeneous devices, such as immersive virtual reality head-mounted display (VR HMD) and tablet-based augmented reality (AR), and simultaneously interact with 3D virtual objects. Therefore, collaborators interact with different interfaces such as virtual reality (VR) users relying on controllers for virtual locomotion and object manipulation, while AR users perform physical locomotion and multi-touch input for object manipulation. The proposed viewpoint-sharing method allows both users to observe and manipulate the objects in interest from the shared point of view, enabling participants to interact with the objects without the need for virtual/physical locomotion. While viewpoint-sharing, instead of changing point of view, the proposed method performs seamless object transformation to provide a shared point of view, reducing motion sickness and associated discomfort. From our user experiment, the viewpoint-share condition resulted in a 35.47% faster task completion time than the baseline condition which is without proposed viewpoint-sharing. The advantage of viewpoint-sharing regarding system usability was significant, while task workloads were similar in the baseline and viewpoint-sharing conditions. We expect that the proposed viewpoint-sharing method allows users to quickly, efficiently, and collaboratively communicate in an object-based CVE, and represents a step forward in the development of effective remote, asymmetric CVE.
The discovery and significance of fast radio bursts
Authors: Lorimer Duncan R. , McLaughlin Maura A. , Bailes Matthew 
Published: June 2024

AbstractIn 2007 we were part of a team that discovered the so-called “Lorimer Burst”, the first example of a new class of objects now known as fast radio bursts (FRBs). These enigmatic events are only a few ms in duration and occur at random locations on the sky at a rate of a few thousand per day. Several thousand FRBs are currently known. While it is now well established that they have a cosmological origin, and about 10% of all currently known sources have been seen to exhibit multiple bursts, the origins of these enigmatic sources are currently poorly understood. In this article, we review the discovery of FRBs and present some of the highlights from the vast body of work by an international community. Following a brief overview of the scale of the visible Universe in §1, we describe the key moments in radio astronomy (§2) that led up to the discovery of the Lorimer burst (§3). Early efforts to find more FRBs are described in §4 which led to the discovery of the first repeating source (§5). In §6, as we close out on the second decade of FRBs, we outline some of the many open questions in the field and look ahead to the coming years where many surprises are surely in store.
(Un)Solvable loop analysis
Authors: Amrollahi Daneshvar , Bartocci Ezio , Kenison George , Kovács Laura , Moosbrugger Marcel , Stankovič Miroslav 
Published: June 2024

AbstractAutomatically generating invariants, key to computer-aided analysis of probabilistic and deterministic programs and compiler optimisation, is a challenging open problem. Whilst the problem is in general undecidable, the goal is settled for restricted classes of loops. For the class of solvable loops, introduced by Rodríguez-Carbonell and Kapur (in: Proceedings of the ISSAC, pp 266–273, 2004), one can automatically compute invariants from closed-form solutions of recurrence equations that model the loop behaviour. In this paper we establish a technique for invariant synthesis for loops that are not solvable, termed unsolvable loops. Our approach automatically partitions the program variables and identifies the so-called defective variables that characterise unsolvability. Herein we consider the following two applications. First, we present a novel technique that automatically synthesises polynomials from defective monomials, that admit closed-form solutions and thus lead to polynomial loop invariants. Second, given an unsolvable loop, we synthesise solvable loops with the following property: the invariant polynomials of the solvable loops are all invariants of the given unsolvable loop. Our implementation and experiments demonstrate both the feasibility and applicability of our approach to both deterministic and probabilistic programs.
Weighted Composition Semigroups on Spaces of Continuous Functions and Their Subspaces
Authors: Kruse Karsten 
Published: June 2024

AbstractThis paper is dedicated to weighted composition semigroups on spaces of continuous functions and their subspaces. We consider semigroups induced by semiflows and semicocycles on Banach spaces $$\mathcal {F}(\Omega )$$

F
(
Ω
)

of continuous functions on a Hausdorff space $$\Omega $$
Ω
such that the norm-topology is stronger than the compact-open topology like the Hardy spaces, the weighted Bergman spaces, the Dirichlet space, the Bloch type spaces, the space of bounded Dirichlet series and weighted spaces of continuous or holomorphic functions. It was shown by Gallardo-Gutiérrez, Siskakis and Yakubovich that there are no non-trivial norm-strongly continuous weighted composition semigroups on Banach spaces $$\mathcal {F}(\mathbb {D})$$

F
(
D
)

of holomorphic functions on the open unit disc $$\mathbb {D}$$
D
such that $$H^{\infty }\subset \mathcal {F}(\mathbb {D})\subset \mathcal {B}_{1}$$

H
∞

⊂
F

(
D
)

⊂

B
1

where $$H^{\infty }$$

H
∞

is the Hardy space of bounded holomorphic functions on $$\mathbb {D}$$
D
and $$\mathcal {B}_{1}$$

B
1

the Bloch space. However, we show that there are non-trivial weighted composition semigroups on such spaces which are strongly continuous w.r.t. the mixed topology between the norm-topology and the compact-open topology. We study such weighted composition semigroups in the general setting of Banach spaces of continuous functions and derive necessary and sufficient conditions on the spaces involved, the semiflows and semicocycles for strong continuity w.r.t. the mixed topology and as a byproduct for norm-strong continuity as well. Moreover, we give several characterisations of their generator and their space of norm-strong continuity.
The approximation capabilities of Durrmeyer-type neural network operators
Authors: Coroianu Lucian , Costarelli Danilo , Natale Mariarosaria , Pantiş Alexandra 
Published: June 2024

AbstractIn this paper, a new family of neural network (NN) operators is introduced. The idea is to consider a Durrmeyer-type version of the widely studied discrete NN operators by Costarelli and Spigler (Neural Netw 44:101–106, 2013). Such operators are constructed using special density functions generated from suitable sigmoidal functions, while the reconstruction coefficients are based on a convolution between a general kernel function $$\chi $$
χ
and the function being reconstructed, f. Here, we investigate their approximation capabilities, establishing both pointwise and uniform convergence theorems for continuous functions. We also provide quantitative estimates for the approximation order thanks to the use of the modulus of continuity of f; this turns out to be strongly influenced by the asymptotic behaviour of the sigmoidal function $$\sigma $$
σ
. Our study also shows that the estimates we provide are, under suitable assumptions, the best possible. Finally, $$L^p$$

L
p

-approximation is also established. At the end of the paper, examples of activation functions are discussed.
Modeling of distortional hardening including plane strain tension and pure shear for a TWIP steel
Authors: Wu Kang , Zhang Shunying , Weiss Matthias , Yoon Jeong Whan 
Published: June 2024

AbstractThis paper focuses on calibrating and modeling of distortional hardening behaviours in twinning induced plasticity steels. True stress-strain curves for uniaxial tension, plane strain tension, and pure shear specimens are inversely identified from corresponding load-displacement curves. The study reveals that accurately predicting the hardening behaviours of TWIP980 steel under plane strain tension and pure shear stress states is challenging with an isotropic hardening model, and a negative hydrostatic effect for TWIP980 is observed through shear testing. A novel distortional hardening model is proposed to simultaneously accommodate the three stress states on the contours of plastic work. Coefficients of the distortional hardening model are calibrated at discrete levels of plastic work and then interpolated to describe the distortion of the initial yield surface. The model is then expanded to consider the true stress-strain curves under uniaxial tension along 0, 45 and 90-degree directions, as well as under the plane strain tension along the 0-degree direction simultaneously. This expansion explicitly incorporates the three true stress-strain curves under uniaxial tension, with the curve of plane strain tension captured by an evolutionary exponent related to plastic work. The developed distortional hardening models demonstrate reasonable reproduction of load-displacement curves for TWIP980 steel under uniaxial tension, plane strain tension, and pure shear stress states.
Pontryagin Maximum Principle for Fractional Delay Differential Equations and Controlled Weakly Singular Volterra Delay Integral Equations
Authors: Gasimov Jasarat J. , Asadzade Javad A. , Mahmudov Nazim I. 
Published: June 2024

AbstractThis article explores two distinct issues. To begin with, we analyze the Pontriagin maximum principle concerning fractional delay differential equations. Furthermore, we investigate the most effective method for resolving the control problem associated with Eq. (1.1) and its corresponding payoff function (1.2). Subsequently, we explore the Pontryagin Maximum principle within the framework of Volterra delay integral equations (1.3). We enhance the outcomes of our investigation by presenting illustrative examples towards the conclusion of the article.