bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bradykinesia in dystonic hand tremor: kinematic analysis and clinical rating
Authors: Matejicka Peter , Kajan Slavomir , Goga Jozef , Straka Igor , Balaz Marek , Janovic Simon , Minar Michal , Valkovic Peter , Hajduk Michal , Kosutzka Zuzana 
Published: June 2024

IntroductionBradykinesia is an essential diagnostic criterion for Parkinson’s disease (PD) but is frequently observed in many non-parkinsonian movement disorders, complicating differential diagnosis, particularly in disorders featuring tremors. The presence of bradykinetic features in the subset of dystonic tremors (DT), either “pure” dystonic tremors or tremors associated with dystonia, remains currently unexplored. The aim of the current study was to evaluate upper limb bradykinesia in DT patients, comparing them with healthy controls (HC) and patients with PD by observing repetitive finger tapping (FT).MethodsThe protocol consisted of two main parts. Initially, the kinematic recording of repetitive FT was performed using optical hand tracking system (Leap Motion Controller). The values of amplitude, amplitude decrement, frequency, frequency decrement, speed, acceleration and number of halts of FT were calculated. Subsequently, three independent movement disorder specialists from different movement disorders centres, blinded to the diagnosis, rated the presence of FT bradykinesia based on video recordings.ResultsThirty-six subjects participated in the study (12 DT, 12 HC and 12 early-stage PD). Kinematic analysis revealed no significant difference in the selected parameters of FT bradykinesia between DT patients and HC. In comparisons between DT and PD patients, PD patients exhibited bigger amplitude decrement and slower FT performance. In the blinded clinical assessment, bradykinesia was rated, on average, as being present in 41.6% of DT patients, 27.7% of HC, and 91.7% of PD patients. While overall inter-rater agreement was moderate, weak agreement was noted within the DT group.DiscussionClinical ratings indicated signs of bradykinesia in almost half of DT patients. The objective kinematic analysis confirmed comparable parameters between DT and HC individuals, with more pronounced abnormalities in PD across various kinematic parameters. Interpretation of bradykinesia signs in tremor patients with DT should be approached cautiously and objective motion analysis might complement the diagnostic process and serve as a decision support system in the choice of clinical entities.
The controlling nutritional status score as a predictor of survival in hematological malignancies: a systematic review and meta-analysis
Authors: Lu Guimei , Li Qingqing 
Published: June 2024

ObjectiveThe controlling nutritional status score (CONUT) has been widely used for ascertaining the prognosis of various cancers. However, its use in patients with hematological malignancies remains unclear. This review examined evidence on the utility of CONUT as a prognostic marker for patients with hematological malignancies.MethodsAll cohort studies that examined the association between CONUT and outcomes of hematological malignancies and were published on the databases of Embase, Scopus, CENTRAL, Web of Science, and PubMed were searched from the inception of the databases to 30 January 2024. The primary outcome was overall survival (OS), and the secondary outcome was progression-free survival (PFS).ResultsA total of 23 studies were available for review. A meta-analysis of 22 studies showed that high CONUT was significantly associated with poor OS in patients with hematological malignancies (HR: 1.95 95% CI: 1.62, 2.35 I2 = 89%). The results remained unchanged on sensitivity and subgroup analyses based on study location, sample size, diagnosis, CONUT cutoff, and the Newcastle–Ottawa Scale score. Only six studies reported data on PFS, and the pooled analysis found that high CONUT was a significant marker for poor PFS in patients with hematological malignancies [hazards ratio (HR): 1.64 95% CI: 1.21, 2.20 I2 = 70%]. These results, too, maintained significance in the sensitivity analysis.ConclusionCONUT is an independent predictor of poor OS in patients with hematological malignancies. The results appear to be valid across different cancer types and with different CONUT cutoffs. Scarce data also suggest that CONUT could predict PFS.
The fusiform skin paddle in fibula free flap: a fusiform-designed skin paddle for maxillofacial soft defect reconstruction and reducing leg wound tension
Authors: Li Shuai , Zheng Xin , Cheng Guo-Sheng , Mai Hua-Ming , He Qian-Ting , Wang An-Xun 
Published: June 2024

ObjectiveTo investigate the feasibility of leg wound closure and reconstruction of maxillofacial soft defect by a fusiform-designed skin paddle in fibula free flap (FFF).MethodsFifty patients who underwent FFF for reconstruction of maxillofacial soft defect were divided into two groups. The fusiform group (20 patients) was treated using a fusiform-designed skin paddle in FFF (skin paddle width less than 2 cm), and leg wound was closed using primary suturing. Reconstruction of the maxillofacial soft defect or filling of dead space was achieved by folding the fusiform skin paddle. The conventional group (30 patients) was treated using the conventional-designed skin paddle (skin paddle width no less than 2.5 cm). The leg wound was closed using mattress suturing or skin graft, while reconstruction of the maxillofacial soft defect or filling of dead space by conventional way. The average postoperative length of hospital stay, healing time of leg wound, and post-surgical complications were recorded at least 6 months after the surgery.ResultsCompared with traditional method, the fusiform-designed skin paddle reduced the average healing time of the leg wound (fusiform group: 11.05 days, conventional group: 14.77 days, P &lt; 0.05). The average length-to-width ratio in fusiform group was significantly greater than that of in conventional group (fusiform group: 5.85, conventional group: 2.93, P &lt; 0.05), and no difference was observed on the graft size of skin paddle between two groups (fusiform group: 23.13, conventional group: 27.13, P &gt; 0.05). The post-surgical early complications of the leg wound in the conventional group were higher than that of in the fusiform group (fusiform group: 0%, conventional group: 6.67%), while the post-surgical late complication of the donor site between the two groups showed no case. Healing disorders of maxillofacial soft reconstruction in the conventional group were higher than that of in the fusiform group (fusiform group: 5.26%, conventional group: 20.69%).ConclusionsFusiform-designed skin paddle for closure of the leg wound and maxillofacial soft defect is a feasible alternative to the conventional- designed skin paddle. The fusiform- designed skin paddle resulted in the less postoperative length of hospital stay, shorter healing time of leg wound and less complication.
Nimotuzumab combined with radiotherapy+/- chemotherapy for definitive treatment of locally advanced squamous cell carcinoma of head and neck: a metanalysis of randomized controlled trials
Authors: Guan Meng , Zhang Dan , Zhao Yue , Mao Mingdi , Shen Kang , Wang Xia , Bi Chun 
Published: June 2024

ObjectivesTo assess the efficacy and safety of nimotuzumab in combination with radiotherapy or chemoradiotherapy for locally advanced head and neck squamous cell carcinoma.MethodsSystematic searches were performed on PubMed, Web of Science, Embase, Cochrane Library, China National Knowledge Infrastructure, China Biomedical Medicine, Wanfang, VIP databases. Seven eligible randomized controlled trials (n = 1012) were selected through rigorous inclusion and exclusion criteria.ResultsA total of 1012 cases were included. including 508 (50.2%) in the nimotuzumab combination treatment group; There were 504 cases (49.8%) in the control group. The results of meta-analysis showed that the overall survival (Hazard Ratio [HR]=0.75, 95% Confidence Interval [CI]: 0.62-0.90, P&lt;0.05), progression-free survival (HR=0.69, 95% CI: 0.54-0.87, P&lt;0.05), complete response rate (Risk Ratio [RR]=1.52, 95% CI: 1.24-1.86, P&lt;0.05), and objective response rate (RR=1.32, 95% CI: 1.17-1.48, P&lt;0.05) were significantly improved in the nimotuzumab combination treatment group compared with the control group. In terms of the incidence of adverse effects, only the incidence of rash was the nimotuzumab combination group higher than in the treatment alone group, and there was no significant difference between the remaining adverse reactions (neutropenia, anemia, nausea/vomiting, mucositis, dermatitis, dysphagia).ConclusionNimotuzumab combined with radiotherapy or chemoradiotherapy is more effective than radiotherapy alone or chemoradiotherapy in locally advanced squamous cell carcinoma of the head and neck, and the safety profile is controllable. Therefore, the addition of nimotuzumab to treatment is expected to be an effective treatment option for this disease. However, more prospective randomized controlled trials are needed to fully explore the effectiveness of this treatment in patients with locally advanced head and neck squamous cell carcinoma.Systematic Review Registrationidentifier PROSPERO (CRD: 42022383313).
Longitudinal follow-up of metformin treatment in Fragile X Syndrome
Authors: Seng Panhaneath , Montanaro Federica Alice Maria , Biag Hazel Maridith Barlahan , Salcedo-Arellano Maria Jimena , Kim Kyoungmi , Ponzini Matthew Dominic , Tassone Flora , Schneider Andrea , Abbeduto Leonard , Thurman Angela John , Hessl David , Bolduc Francois V. , Jacquemont Sebastien , Lippé Sarah , Hagerman Randi J. 
Published: June 2024

IntroductionMetformin has been used as a targeted treatment to potentially improve cognition and slow the typical IQ decline that occurs during development among individuals with fragile X syndrome (FXS). In this follow-up study, we are following the trajectory of IQ and adaptive behavior changes over 1 to 3 years in individuals with FXS who are clinically treated with metformin in an open label trial.MethodIndividuals with FXS ages 6 to 25 years (mean 13.15 ± 5.50) and nonverbal IQ mean 57.69 (±15.46) were treated for 1–3 years (1.88 ± 0.63). They all had a baseline IQ test using the Leiter-III non-verbal cognitive assessment and the Vineland-III adaptive behavior assessment before the start of metformin. Repeat Leiter-III and Vineland-III were completed after at least 1 year of metformin (500–1,000 mg/dose given twice a day).ResultThere were no significant changes in non-verbal IQ or in the adaptive behavior measurements at FDR &lt; 0.05. The findings thus far indicate that both IQ and adaptive behavior are stable over time, and we did not see a significant decline in either measure.ConclusionOverall, the small sample size and short follow-up duration limit the interpretation of the effects of metformin on cognitive development and adaptive functioning. There is individual variability but overall for the group there was no significant decline in IQ or adaptive behavior.
Neuropsychological analysis of anxiety and executive control of motor patterns in athletes and non-athletes
Authors: Caramés José María , Reigal Rafael E. , Morales-Sánchez Verónica , Pastrana-Brincones José Luis , Anguera M. Teresa , Hernández-Mendo Antonio 
Published: June 2024

IntroductionEven simple tapping tasks require cognitive processes. Some variants of the Finger Tapping Test (FTT) may reveal cognitive aspects associated with frontal processing, including executive functions such as inhibition, or emotional aspects such as anxiety. A context of particular interest for the application of cognitive-motor-anxiety interactions is sports. Although athletes generally exhibit better anxiety levels, they may experience heightened anxiety before important competitions. The problem lies in determining whether the application of anxiety control techniques can be useful in pre-competition situations, given the lack of quick and easy methods to detect if an athlete is experiencing anxiety at a particular moment.MethodsThis exploratory study evaluated anxiety using online versions of questionnaires (ISRA, the Competitive State Anxiety Inventory-2, and STAI) and applied a variant of the FTT to 204 participants, both athletes and non-athletes. The scores were compared and correlated.ResultsAthletes exhibited lower general anxiety and greater cognitive resistance to interference (better cognitive inhibition). Non-athletes displayed a particular parameter in the FTT variant that differed from the one obtained by athletes and exhibited higher anxiety levels. In the athletes’ group only, anxiety was correlated with a specific parameter of the FTT task.DiscussionOur conclusion is that this parameter holds potential relevance in elite sports performance to detect if an athlete is experiencing anxiety. It could be of particular interest in psychological interventions in sports. Further investigation is warranted to fully explore this potential.
Psychosis detection in dementia: a systematic review of diagnostic test accuracy studies
Authors: Atchison Kayla , Wu Pauline , Watt Jennifer A. , Seitz Dallas , Ismail Zahinoor , Goodarzi Zahra 
Published: June 2024

IntroductionSymptoms of psychosis, characterized by delusions and hallucinations, are commonly experienced by persons living with dementia. A systematic review was completed to identify tools to evaluate symptoms of psychosis compared to a reference standard in persons with dementia. Articles reporting correlation values between psychosis tools were also identified.MethodsThe search concepts psychosis, dementia, and diagnostic accuracy were used to search MEDLINE, PsycINFO, and Embase. Included articles meeting the primary objective described a tool to assess symptoms of psychosis, delusions, or hallucinations in persons with dementia, a reference standard form of diagnostic assessment for psychosis, and diagnostic accuracy outcomes for the psychosis tool. Secondary objective articles reported correlation values between two or more psychosis tools in persons with dementia.ResultsOne study met the primary objective and described the sensitivity and specificity of the Neuropsychiatric Inventory (NPI) and Columbia University Scale for Psychopathology in Alzheimer's Disease (CUSPAD) in identifying symptoms of psychosis, hallucinations, and delusions. The sensitivity of the NPI and CUSPAD in identifying symptoms of psychosis was 83 and 90%, respectively. Nine studies meeting the secondary objective described eleven unique tools and examined the degree to which tools used to assess psychotic symptoms in persons with dementia were related.DiscussionThe NPI and CUSPAD were identified in a single study as psychosis tools that have been evaluated against a reference standard of psychosis assessment in persons with dementia. Various tools to assess the burden of psychotic symptoms in persons with dementia exist, but the diagnostic accuracy of existing tools remains understudied. Further research on the comparative utility and diagnostic accuracy is required for all psychosis tools used with persons with dementia.
Fermented beverages among indigenous Latin American societies
Authors: Lasso García Christian , German Bermúdez Fátima Andrea , Vanden Berghe Wim , Gabriela Zurita-Benavides María , Orellana-Manzano Andrea 
Published: June 2024

PurposeTraditional fermented beverages are a valuable cultural, economic, and social heritage of Latin American societies that deserve to be preserved and strengthened with sustainable development and respect for diversity. Therefore, this article will demonstrate, through scientific literature, the importance for indigenous societies and the nutritional contributions of the most traditional beverages of North and South America.MethodsThis systematic review followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) verification protocol. The study focused on exploring the nutritional information of South and Central American fermented beverages. The search was conducted in the Biomed, PubMed, ScienceDirect, Scopus, Scielo, and Google Scholar databases to identify publications published within the past 15 years.ResultsHowever, the presence of toxic compounds such as biogenic amines and phenols that affect the quality of the product and human health has been detected. In addition, it was found that macro-and micronutrients, vitamins, and microorganisms differ according to the type of raw material used. It was concluded that corn is the most widely used raw material to produce fermented beverages in Latin America. At the same time, Mexico has conducted more research on this product, and most analyses are being carried out on the use of corn in the production of fermented beverages. In addition, several studies have shown that using validated and standardized methodologies to detect biogenic weapons is crucial to ensure accurate identification, effective response, and compliance with legal and security requirements in this critical area.
Economic Value of Peer Support Program in German Hospitals
Authors: Roesner Hannah , Neusius Thomas , Strametz Reinhard , Mira José Joaquín 
Published: June 2024

ObjectivesAcknowledging peer support as the cornerstone in mitigating the psychosocial burden arising from the second victim phenomenon, this study assesses the economic benefits of a Peer Support Program (PSP), compared to data of the Resilience In Stressful Events (RISE) program in the US, within the acute inpatient care sector in Germany.MethodsEmploying a Markov model, this economic evaluation analyzes the cost benefits, including sick day and dropout costs, over a 1-year period, comparing scenarios with and without the Peer Support Program from a hospital perspective. The costs were calculated as an example based on a hospital with 1,000 employees. The estimations are considered conservative.ResultsThe anticipated outcomes demonstrate an average cost saving of €6,672 per healthcare worker participating in the Peer Support Program, leading to an annual budgetary impact of approximately €6,67 Mio. for the studied hospital.ConclusionThe integration of a PSP proves economically advantageous for German hospitals, not only preserving financial resources but also reducing absenteeism, and mitigating turnover, thereby enhancing overall patient care.
Pembuatan Pupuk Organik Tofu Go Green dari Limbah Cair Tahu di Kelurahan Gedanganak Ungaran Timur
Authors: Septi Antika  , Nerischa Adisti Rahma Aulia  , Kristi Ramadhani  , Ryzky Dwi Mulyaningrum  , Muhammad Sultan Al-Zukhruf  , Sri Wahyuni  
Published: June 2024

Environmental pollution by human activities is often found in the environment around residences that live close to industry in both the formal and informal sectors, one of which is the tofu factory. Gedanganak Village is one of the sub-districts located in West Ungaran sub-district, Semarang Regency. Gedanganak sub-district consists of several hamlets, where the residents make their living as laborers and tofu craftsmen. People who do not know how to use liquid waste from tofu factories can be overcome by providing information, education and training to process liquid waste from tofu factories into organic fertilizer to achieve food security and increase people's income in Gedanganak Village. There is a need for liquid waste processing in the tofu industry. One innovation that can be done to reduce tofu waste is by using it into Tofu Go Green products. The purpose of this empowerment is to provide empowerment regarding the use of tofu liquid waste into organic fertilizer in the Gedanganak Village Community. The methods used are education, training and demonstration The result of Community Empowerment with training in making organic fertilizer from tofu liquid waste is that the community is able to independently utilize tofu liquid waste which has not previously been utilized.

ABSTRAK
Pencemaran lingkungan oleh aktivitas manusia kerap ditemui dilingkungan sekitar tempat tinggal yang bermukim dekat dengan industri baik sektor formal dan informal, sektor informal salah satunya adalah pabrik tahu. Kelurahan Gedanganak merupakan salah satu kelurahan yang terletak di kecamatan Ungaran Barat Kabupaten Semarang. Kelurahan Gedanganak terdiri dari beberapa dusun, dimana penduduknya bermata pencarian sebagai buruh dan pengrajin tahu. Masyarakat yang tidak mengetahui bagaimana pemanfaatan limbah cair pabrik tahu dapat diatasi dengan memberikan informasi,edukasi, dan pelatihan mengolah limbah cair pabrik tahu menjadi pupuk organik untuk mewujudkan ketahanan pangan dan menambah penghasilan masyarakat di Kelurahan Gedanganak. diperlukannya pengolahan limbah cair pada industi tahu tersebut, salah satu inovasi yang dapat dilakukan untuk mengurangi limbah tahu tersebut yaitu dengan memanfaatkannya menjadi produk Tofu Go Green. Tujuan dari pemberdayaan ini adalah untuk memberikan empowerment mengenai pemanfaatan limbah cair tahu menjadi pupuk organik pada Masyarakat Kelurahan Gedanganak. Metode yang digunakan adalah edukasi, pelatihan dan demonstrasi. Hasil dari Pemberdayaan Masyarakat dengan pelatihan pembuatan pupuk organik dari limbah cair tahu yaitu masyarakat mampu mandiri untuk memanfaatkan limbah cair tahu yang sebelumnya belum dimanfaatkan.
Upaya Peningkatan Pengetahuan Remaja dalam Deteksi Dini Kanker Payudara dengan Pemeriksaan Payudara Sendiri (SADARI) di SMP Muhammadiyah 8 Surakarta
Authors: Wulandari Retno , Desy Widyastutik  , Wijayanti  , Deny Eka W  
Published: June 2024

Data from Riskesda in 2013 and 2018 shows an increase in the prevalence of cancer in Indonesia from 1.4% to 1.49%. The prevalence of cancer in Indonesia based on age groups shows that a significant increase begins to occur at ages above 35 years. Screening is a government effort or a simple and easy test carried out on healthy populations with the aim of distinguishing people who are sick or at risk of contracting disease from healthy people. One form of increasing public awareness about the symptoms and signs of cancer is providing public education about breast self-examination (BSE). Counseling was carried out to 15 female students at SMP Muhammadiyah 8 Surakarta and the results showed that 100% of the students were able to do BSE themselves.

ABSTRAK
Kanker payudara adalah jenis kanker yang menduduki urutan kedua terbanyak di dunia pada wanita. Berdasarkan survei dari World Health Organization (WHO) di tahun 2018, kanker payudara dialami oleh 8% hingga 9% wanita di dunia (WHO, 2018). Tahun 2018 kanker payudara menyebabkan kematian kedua dari total keseluruhan semua jenis kanker (348.809 kasus) pada wanita di Indonesia, kanker payudara menyumbang sebesar 58.256 (16,7%) (Kemenkes RI, 2021). Skrining adalah upaya pemerintah atau tes yang sederhana dan mudah yang dilaksanakan pada populasi masyarakat sehat yang bertujuan untuk membedakan masyarakat yang sakit atau beresiko terkena penyakit di antara masyarakat yang sehat. Salah satu bentuk peningkatan kesadaran masyarakat tentang gejala dan tanda-tanda kanker salah satunya adalah pemberian edukasi masyarakat tentang pemeriksaan Payudara sendiri (SADARI). Penyuluhan dilakukan kepada siswi di SMP Muhammadiyah 8 Surakarta sebanyak 15 siswi didapatkan hasil bahwa 100 % siswa sudah dapat melakukan SADARI sendiri.