bluuebunny/crossref_metadata_2025_split huggingface dataset:
A variable neighborhood search for the median location problem with interconnected facilities
Authors: Lozano‐Osorio I. , Sánchez‐Oro J. , López‐Sánchez A.D. , Duarte A. 
Published: April 2024

AbstractThe ‐median problem has been widely studied in the literature. However, there are several variants that include new constraints to the classical problem that make it more realistic. In this work, we study the variant that considers interconnected facilities, that is, the distances between each pair of facilities are less than or equal to a certain threshold . This optimization problem, usually known as the median location problem with interconnected facilities, consists of locating a set of interconnected facilities to minimize the distance between those interconnected facilities and the demand points. The large variety of real‐world applications that fit into this model makes it attractive to design an algorithm able to solve the problem efficiently. To this end, a procedure based on the variable neighborhood search methodology is designed and implemented by using problem‐dependent neighborhoods. Experimental results show that our proposal is able to reach most of the optimal solutions when they are known. Additionally, it outperforms previous state‐of‐the‐art methods in those instances where the optima are unknown. These results are further confirmed by conducting nonparametrical statistical tests.
Promoting resident thriving in nursing homes: A qualitative study
Authors: Baxter Rebecca , Corneliusson Laura , Björk Sabine , Edvardsson David 
Published: April 2024

AbstractAimTo explore how staff promote resident thriving in an Australian nursing home.DesignQualitative research design using content analysis.MethodsInterviews were held with 14 nursing staff working in an Australian nursing home in March/April 2018. Data were analysed using qualitative content analysis.ResultsFour themes were revealed: promoting personalized care; promoting opportunities for autonomy; promoting connection and meaning; and promoting a curated environment.ConclusionsStaff promoted resident thriving in relation to everyday care, activities, capabilities, relationships and the lived environment. Interventions that were perceived to promote thriving were described relative to the nurse, the resident, the care team and the wider nursing home context.Implications for the Profession and/or Patient CareThe findings provide novel insight into the understanding and application of the concept of thriving in long‐term care from nursing staffs' perspective.ImpactWhat Problem did the Study Address?Nursing home staff are uniquely positioned to support resident thriving through person‐centred care, yet little is known about how staff support promotion of thriving for nursing home residents in their everyday practice.What were the Main Findings?Nursing home staff perceived that they promoted thriving by personalizing care and supporting autonomy, connection, meaning and pleasure for residents.Where and on Whom will the Research have an Impact?These findings are of interest for the clinicians, educators and researchers who develop, implement and evaluate interventions to improve place‐related well‐being in nursing homes.Reporting MethodCORE‐Q checklist.Patient or Public ContributionNo patient or public contribution occurred for this study as this research focused on exploring staffs' perspectives from the specific viewpoint of their personal experience.
Hyponatremia‐associated hospital visits are not reduced by early electrolyte testing in older adults starting antidepressants
Authors: Lane Natasha E. , Bai Li , Seitz Dallas P. , Juurlink David N. , Paterson J. Michael , Guan Jun , Stukel Therese A. 
Published: April 2024

AbstractBackgroundClinical practice guidelines recommend early serum electrolyte monitoring when starting antidepressants in older adults due to the increased risk of hyponatremia. It is unclear whether this monitoring improves outcomes.MethodsPopulation‐based, retrospective cohort study of Ontario adults aged ≥66 years who initiated therapy with a selective serotonin reuptake inhibitor (SSRI) or selective norepinephrine reuptake inhibitor (SNRI) between April 1, 2013, and January 31, 2020. The index date was the date of the first such prescription, and the exposure of interest was serum electrolyte measurement during the subsequent 7 days. The primary outcome was any emergency department or hospital admission with hyponatremia within 8–60 days of antidepressant initiation. Poisson regression models compared individuals who had versus did not have their serum electrolytes tested in the week following SSRI/SNRI initiation, weighting by propensity score‐based overlap weights.ResultsAmong the 420,085 patients aged ≥66 years initiating treatment with an SSRI/SNRI, 26,808 (6.4%) had serum electrolytes measured in the subsequent 7 days and 6109 (1.5%) subsequently presented to hospital with hyponatremia. The time from drug initiation to hospitalization varied (median 29, interquartile range [IQR] 17–44 days), and the median sodium concentration measured in the community (136, IQR 133–138 mmol/L) was marginally higher than those at the time of hospitalization (132, IQR 130–134 mmol/L). Patients who underwent electrolyte testing in the week following SSRI/SNRI treatment were more likely to attend an emergency department (ED) or hospital with hyponatremia within 8–60 days relative to those who did not (relative risk = 2.31, 95% confidence interval: 2.16–2.46).ConclusionsTesting serum electrolytes in the week after starting an SSRI/SNRI is not associated with a reduced risk of a hospital visit with hyponatremia. These findings do not support current guidelines recommending routine electrolyte monitoring.
Partial melting mechanisms of peraluminous felsic magmatism in a collisional orogen: An example from the Khondalite belt, North China craton
Authors: Huang Guangyu , Liu Hao , Guo Jinghui , Palin Richard M. , Zou Lei , Cui Weilong 
Published: April 2024

AbstractSedimentary‐derived (S‐type) granites are an important product of orogenic metamorphism, and a range of subtypes can be recognized by differences in field occurrence, mineralogy and geochemistry. These subtypes can reflect variations of initial protolith composition, partial melting reactions, pressure and temperature of anatexis, or magmatic processes that occur during ascent through the crust (e.g. mineral fractional crystallization or crustal assimilation). Together, these diverse factors complicate geological interpretation of the history of peraluminous felsic melt fractions in orogenic settings. To assess the influence of these factors, we performed integrated field investigation, petrology, geochemistry, geochronology and phase equilibrium modelling on a series of leucosomes within migmatite associated with different S‐type granites within the Khondalite belt, North China craton (NCC), which is an archetypal collisional orogen. Three types of leucosome are recognized in the east Khondalite belt: leucogranitic leucosome, K‐feldspar (Kfs)‐rich granitic leucosome and garnet (Grt)‐rich granitic leucosome. Phase equilibrium modelling of partial melting and fractional crystallization processes indicate that the leucogranitic leucosomes were mostly produced through fluid‐present melting, Kfs‐rich granitic leucosomes are produced through muscovite dehydration melting with 3 vol.% garnet fractional crystallization, and Grt‐rich granitic leucosomes are produced through biotite dehydration melting with 20–40 vol.% K‐feldspar fractional crystallization and up to 20 vol.% peritectic garnet entrainment. Mineral fractional crystallization and peritectic mineral entrainment occur in the source during melting, and play equally important roles in partial melting mechanisms in terms of affecting the geochemical compositions of granitic melts. Thus, we suggest that peraluminous felsic magmas preserved in collisional orogens are dominantly produced by fluid‐absent melting in the middle to deep continental crust, although extraction of low‐volume melt fractions from an anatectic source region at shallower depths during fluid‐present melting can also generate small amounts of S‐type granites that subsequently crystallize at high structural levels in the crust.
Single‐shot differential phase contrast microscopy using ring‐shaped polarisation multiplexing illumination
Authors: Wang Shengping , Ma Yifu , Xie Mengyuan , Yao Manhong , Zhang Zibang , Zhong Jingang 
Published: April 2024

AbstractWe propose a differential phase contrast microscopy that enables single‐shot phase imaging for unstained biological samples. The proposed approach employs a ring‐shaped LED array for polarisation multiplexing illumination and a polarisation camera for image acquisition. As such, multiple images of different polarisation angles can be simultaneously captured with a single shot. Through polarisation demultiplexing, the sample phase can therefore be recovered from the single‐shot measurement. Both simulations and experiments demonstrate the effectiveness of the approach. We also demonstrate that ring‐shaped illumination enables higher contrast and lower‐distortion imaging results than disk‐shaped illumination does. The proposed single‐shot approach potentially enables phase contrast imaging for live cell samples in vitro.Lay Description: We propose a microscopy that enables imaging of transparent samples, unstained cells, etc. We demonstrate that the proposed method enables higher contrast and lower‐distortion imaging results than conventional methods, and significantly improves imaging efficiency. The proposed method potentially enables dynamic imaging for live cell samples in vitro.
Analysing the patient experience of COVID‐19: Exploring patients' experiences of hospitalisation and their quality of life post discharge
Authors: Reay Abigail , Dismore Lorelle , Aujayeb Avinash , Dotchin Catherine , Tullo Ellen , Steer John , Swainston Katherine 
Published: April 2024

AbstractAims and ObjectivesWe sought to gain an understanding of the patient experience during their hospital stay for COVID‐19, and the impact of COVID‐19 on quality of life post discharge.BackgroundSymptoms of COVID‐19 include a persistent cough, dyspnoea and fatigue. Individuals with comorbidities such as cardiovascular disease have a higher risk of contracting COVID‐19 and approximately 20% of those diagnosed with COVID‐19 are admitted to hospital. Following discharge from hospital, 40% of patients report a worsened quality of life and up to 87% of those discharged from hospital have experienced ‘long COVID’.DesignA qualitative design was used to understand patient experience of hospitalisation following a diagnosis of COVID‐19, and their experiences following discharge from hospital.MethodsTen patients with a previous diagnosis of COVID‐19 took part in semi‐structured interviews regarding their experiences of hospitalisation and the impact on quality of life post‐discharge.ResultsThe results identified three key themes from the interviews: communication and the inpatient experience, symptoms following discharge and regaining independence. Patients discussed their experience of hospitalisation and how this continued to impact their emotional well‐being post‐discharge. However, patients appeared to push themselves physically to improve their health, despite continued COVID‐19 symptoms.ConclusionPatients hospitalised following a diagnosis of COVID‐19 experienced psychological distress during their hospital stay, as well as 3‐months post‐discharge. We suggest the use of psychosocial interventions to support patients post‐discharge.Relevance to Clinical PracticeThe results of this study provide a greater understanding of the patient experience during their hospital stay, which can support nursing staff practice. Additionally, the study provides in depth knowledge of personal experiences of patients diagnosed with COVID‐19 and the impact following hospital discharge.Patient or Public ContributionPatient's took part in semi‐structured interviews via telephone to support the aims and objectives of this study.
Endogenous subsidies for cleaner products: The role of ecofriendly consumers
Authors: Tarola Ornella , Vergari Cecilia 
Published: April 2024

AbstractIn a vertically differentiated duopoly, we assume that environmental subsidies are endogenously determined by the demand for dirtier goods and the relative greenness of cleaner alternatives. By contemplating the possibility that a subsidy targets either consumers or firms, we study how the impact of a subsidy changes with its recipients, consumers versus firms. A consumer‐based subsidy is environmentally enhancing and increases firms' profits at equilibrium, while it hurts consumers. Overall, however, it is welfare improving. A firm‐based subsidy makes firms better off but may be environmentally harmful and has the paradoxical effect of hurting consumers buying the cleaner variant. Moreover, it is welfare detrimental on the whole.
Data exclusivity and patent monopoly extension: A view from Australia
Authors: Henriksen Teddy , Henriksen Simone 
Published: April 2024

AbstractData exclusivity and patents are important to the pharmaceutical industry, and both these regimes coexist in the pharmaceutical landscape. Both data exclusivity and patents provide market exclusivity through monopoly periods. Because data exclusivity and patents can protect the same pharmaceutical, beginning at different times in the pharmaceutical lifecycle and having different durations, these terms may not coincide, and each can extend the effective market exclusivity period of the other. For example, when data exclusivity persists beyond patent expiry for a pharmaceutical, subsequent entrant access to the market is restricted and the period during which originators can charge high prices is extended. This article seeks to eliminate the situation where patent monopolies have expired, but data exclusivity remains in force by proposing a method to ensure that data exclusivity and patent terms expire simultaneously. Further, the proposal maintains the protection to innovators afforded by both data exclusivity and patents, recognising that these regimes protect different things in pharmaceutical development.
COVID‐19 disease in children and adolescents following allogeneic hematopoietic stem cell transplantation: A report from the Turkish pediatric bone marrow transplantation study group
Authors: Bozkurt Ceyhun , Hazar Volkan , Malbora Barış , Küpesiz Alphan , Aygüneş Utku , Fışgın Tunç , Karakükçü Musa , Kuşkonmaz Barış , Kılıç Suar Çakı , Bayırlı Derya , Arman Bilir Özlem , Yalçın Koray , Gözmen Salih , Uygun Vedat , Elli Murat , Sarbay Hakan , Küpesiz Funda Tayfun , Şaşmaz Hatice İlgen , Aksoy Başak Adaklı , Yılmaz Ebru , Okur Fatma Visal , Tekkeşin Funda , Yenigürbüz Fatma Demir , Özek Gülcihan , Atay Abdullah Avni , Bozkaya İkbal Ok , Çelen Suna , Öztürkmen Seda , Güneş Adalet Meral , Gürsel Orhan , Güler Elif , Özcan Alper , Çetinkaya Duygu Uçkan , Aydoğdu Selime , Özbek Namık Yaşar , Karasu Gülsün , Sezgin Gülay , Doğru Ömer , Albayrak Davut , Öztürk Gülyüz , Aksoylar Serap , Daloğlu Hayriye , Odaman Al Işık , Evim Melike Sezgin , Akbayram Sinan , Öncül Yurday , Zengin Emine , Albayrak Canan , Timur Çetin , Kar Yeter Düzenli , Çakmaklı Hasan Fatih , Tüfekçi Özlem , Töret Ersin , Antmen Bülent 
Published: April 2024

AbstractBackgroundData on the risk factors and outcomes for pediatric patients with SARS‐CoV‐2 infection (COVID‐19) following hematopoietic stem cell transplantation (HSCT) are limited.ObjectivesThe study aimed to analyze the clinical signs, risk factors, and outcomes for ICU admission and mortality in a large pediatric cohort who underwent allogeneic HSCT prior to COVID‐19 infection.MethodIn this nationwide study, we retrospectively reviewed the data of 184 pediatric HSCT recipients who had COVID‐19 between March 2020 and August 2022.ResultsThe median time from HSCT to COVID‐19 infection was 209.0 days (IQR, 111.7–340.8; range, 0–3845 days). The most common clinical manifestation was fever (58.7%). While most patients (78.8%) had asymptomatic/mild disease, the disease severity was moderate in 9.2% and severe and critical in 4.4% and 7.6%, respectively. The overall mortality was 10.9% (n: 20). Deaths were attributable to COVID‐19 in nine (4.9%) patients. Multivariate analysis revealed that lower respiratory tract disease (LRTD) (OR, 23.20, p: .001) and lymphopenia at diagnosis (OR, 5.21, p: .006) were risk factors for ICU admission and that HSCT from a mismatched donor (OR, 54.04, p: .028), multisystem inflammatory syndrome in children (MIS‐C) (OR, 31.07, p: .003), and LRTD (OR, 10.11, p: .035) were associated with a higher risk for COVID‐19‐related mortality.ConclusionWhile COVID‐19 is mostly asymptomatic or mild in pediatric transplant recipients, it can cause ICU admission in those with LRTD or lymphopenia at diagnosis and may be more fatal in those who are transplanted from a mismatched donor and those who develop MIS‐C or LRTD.
Gastric sleeve as an extra‐anatomical roux for biliary reconstruction in a pediatric third liver transplant
Authors: Hakeem Abdul Rahman , Gee Harrison , Attia Magdy , Raj Prasad K. 
Published: April 2024

AbstractBackgroundSir Roy Calne in 1976 described “Biliary reconstruction is the Achilles heel of liver transplantation,” and it remains true. In some patients, such as those with short‐gut syndrome and concomitant biliary atresia, neither duct to duct nor Roux biliary reconstruction is feasible.MethodsWe present a case of child's third liver transplant (LT), where an innovative extra‐anatomical biliary bypass was created using a sleeve from greater curvature of the stomach.ResultsThe patient is well nearly 10 years following the LT.ConclusionsThis technique could prove to be an important addition to the armamentarium of a surgeon in difficult retransplants and in patients with short‐gut syndrome as it provides a viable option with good long‐term outcome.
ChloroSpec: A new in vivo chlorophyll fluorescence spectrometer for simultaneous wavelength‐ and time‐resolved detection
Authors: Nanda Sanchali , Shutova Tatyana , Cainzos Maximiliano , Hu Chen , Sasbrink Bart , Bag Pushan , Blanken Tristian den , Buijs Ronald , Gracht Lex van der , Hendriks Frans , Lambrev Petar , Limburg Rob , Mascoli Vincenzo , Nawrocki Wojciech J , Reus Michael , Parmessar Ramon , Singerling Björn , Stokkum Ivo H M , Jansson Stefan , Holzwarth Alfred R. 
Published: April 2024

AbstractChlorophyll fluorescence is a ubiquitous tool in basic and applied plant science research. Various standard commercial instruments are available for characterization of photosynthetic material like leaves or microalgae, most of which integrate the overall fluorescence signals above a certain cut‐off wavelength. However, wavelength‐resolved (fluorescence signals appearing at different wavelengths having different time dependent decay) signals contain vast information required to decompose complex signals and processes into their underlying components that can untangle the photo‐physiological process of photosynthesis. Hence, to address this we describe an advanced chlorophyll fluorescence spectrometer ‐ ChloroSpec ‐ allowing three‐dimensional simultaneous detection of fluorescence intensities at different wavelengths in a time‐resolved manner. We demonstrate for a variety of typical examples that most of the generally used fluorescence parameters are strongly wavelength dependent. This indicates a pronounced heterogeneity and a highly dynamic nature of the thylakoid and the photosynthetic apparatus under actinic illumination. Furthermore, we provide examples of advanced global analysis procedures integrating this three‐dimensional signal and relevant information extracted from them that relate to the physiological properties of the organism. This conveniently obtained broad range of data can make ChloroSpec a new standard tool in photosynthesis research.
Why temporality matters in collective resistance: Shifting civic norms in a post‐traumatic society
Authors: Cayli Messina Baris 
Published: April 2024

AbstractWhat is the role of civic norms for social change after traumatic events, and how do those norms shape collective resistance? The present study seeks to address this urgent query by examining Sicilians' culture war against the mafia. Based on rigorous ethnographic research over a period of 7 years (2016–2023), an extensive database was created, which included 77 commemorative events, a guided city tour, 54 interviews with antimafia activists, and 89 audio–visual recordings totaling 1768 min. I introduce two analytical concepts, “informative rituals” and “transmissive rituals,” that offer a new perspective on how activists leverage the civic norms of social bonds to realize their objectives. I argue that shifting civic norms in a post‐traumatic society is not only driven by collective resistance but also requires significant time in the presence of an oppressive force. This study proposes that, for a socially traumatized community attempting to shift civic norms, prolonged and strenuous endeavors are required in order to thoroughly permeate those norms among the general public. The findings demonstrate that the consolidation of civic norms within post‐traumatic societies is highly contingent upon its temporal context and sustainability, which explains why culture wars frequently necessitate a long‐term communal investment.
Frequency of red blood cell phenotypes from genotyped Australian blood donors
Authors: Jacko Georgina , Powley Tanya , Daly James 
Published: April 2024

AbstractBackgroundAustralian Red Cross Lifeblood (Lifeblood) performs human erythrocyte antigen (HEA) genotyping for a subset of repeat whole‐blood donors through preferential selection which aims to maximise variation of results and possibility of identifying donors lacking high frequency red cell antigens.Materials and MethodsThe HEA Molecular Bead chip™ assay is used by Lifeblood for donor genotyping. A review of all donor HEA genotype data from March 2019 to May 2022 (3 years) was conducted.ResultsHEA genotyping was performed for 20,185donors. Due to selective genotyping of donors, a higher frequency of R1R1 predicted phenotype was identified. However, frequencies of other red cell phenotypes were relatively similar to previous reported in the Australian population. A small number of donors with rare red cell phenotypes was identified.ConclusionGenotyping of blood donors provides an available pool of extended matched red blood cell products for matching to recipients. Additionally genotyping can improve the identification of donors with rare phenotypes. Whilst limitations exist, genotyping may reduce the need for labour intensive serotyping, improve blood inventory management, and may be useful in donor recruitment and retention.