bluuebunny/crossref_metadata_2025_split huggingface dataset:
Headache in Systemic Lupus Erythematosus vs Multiple Sclerosis: A Prospective Comparative Study
Authors: Katsiari Christina G. , Vikelis Michail , Paraskevopoulou Eleftheria S. , Sfikakis Petros P. , Mitsikostas Dimos D. 
Published: July 2011

Objective.— To clarify whether headache, and particularly migraine, belongs to the spectrum of neurologic manifestations of systemic lupus erythematosus (SLE), the archetypal autoimmune disease.Methods.— Consecutive SLE patients were matched 1:1 for age, gender, and level of education with healthy control subjects. A representative subgroup of SLE patients were also matched with patients suffering from multiple sclerosis (MS), a nervous system‐specific autoimmune disease. All study participants were assessed for headache present in the previous year. Anxiety, depression, and quality of life were also estimated at baseline. During the following year, all participants were assessed every 3 months using specific headache diaries.Results.— Seventy‐two SLE/control pairs and 48 MS patients completed 12 months of follow‐up. Prevalence of migraine, with or without aura, was similar between SLE patients (21%), MS patients (23%), and controls (22%), as was the prevalence of frequent tension‐type headache. Duration and severity of migraine attacks were milder in SLE patients than controls. Only chronic tension‐type headache was significantly more prevalent in SLE patients (12.5%) compared to controls (1.4%). MS patients also presented increased frequency of chronic tension‐type headache (8.3%). No associations of any headache type with particular clinical manifestations, autoantibody, or disease activity, either in SLE or MS patient groups, were found. Irrespective of the presence of headache, anxiety symptoms and impaired quality of life were more frequent among SLE than MS patients or controls.Conclusion.— Migraine should be no longer considered a neurologic manifestation of systemic or organ‐specific autoimmunity. Increased migraine prevalence in these patients found in previous studies could be due to methodological weaknesses.
Bioactive Coils Cause Headache and Fever After Endovascular Treatment of Intracranial Aneurysms
Authors: Takigawa Tomoji , Matsumaru Yuji , Nakai Yasunobu , Nakamura Kazuhiro , Hayakawa Mikito , Tsuruta Wataro , Matsumura Akira 
Published: July 2011

Background.— Based on our encounters with patients who have been treated for unruptured intracranial aneurysms by endovascular coil embolization using bioactive coils, we observed that such patients often present with headaches and fever.Objective.— The purpose of this study was to evaluate the incidence of headache and fever after coil embolization using bioactive coils.Methods.— A database of 92 intracranial unruptured aneurysm patients (88 patients who did not have chronic headaches or migraines before treatment) on whom coil embolization had been performed between July 2007 and October 2010 was retrospectively assessed. Forty‐five aneurysms (43 patients) were treated using bioactive coils and the other aneurysms were treated using bare coils. We analyzed the incidence and duration of headache, temperature, C‐reactive protein, and white blood cell count before and after coil embolization and compared the 2 groups.Results.— Forty‐one patients (46.6%) reported onset of headaches just after treatment. Headache incidences were significantly greater in the patients treated with bioactive coils (bioactive coil group: 62.8% [27/43] vs bare coil group: 31.1% [14/45], P = .003), and the duration of headaches was significantly longer in the bioactive coil group (bioactive coil group: 3.44 ± 1.22 days vs bare coil group: 2.40 ± 1.17 days, P = .027). Seventy‐one patients (80.7%) had incidences of fever (over 37°C) after treatment (bioactive coil group: 83.7% [36/43] vs bare coil group: 77.8% [35/45], P = .663). The duration of fever was significantly longer in the bioactive coil group (bioactive coil group: 2.9 ± 1.4 days vs bare coil group: 1.9 ± 1.1 days, P = .0017), and temperatures at 1, 2, or 3 days after treatment were significantly higher in the bioactive coil group (respective temperatures at 1, 2, 3 days after treatment: bioactive coil group: 37.42 ± 0.49, 37.19 ± 0.45, 37.00 ± 0.49 vs bare coil group: 37.14 ± 0.38, 36.96 ± 0.41, 36.63 ± 0.51, P = .009, P = .0246, P = .0032). There were no significant differences in C‐reactive protein level and white blood cell count 1 and 3 days after treatment between 2 groups.Conclusions.— Bioactive coils induce headache and fever after coil embolization for intracranial aneurysms due to the inflammatory effects of polyglycolic acid used to accelerate aneurysm fibrosis and neointimal formation.
Long‐Term Evaluation of Sumatriptan and Naproxen Sodium for the Acute Treatment of Migraine in Adolescents
Authors: McDonald Susan A. , Hershey Andrew D. , Pearlman Eric , Lewis Donald , Winner Paul K. , Rothner David , Linder Steven L. , Runken M. Chris , Richard Nathalie E. , Derosier Frederick J. 
Published: July 2011

Objectives.— To evaluate the long‐term safety, tolerability, effectiveness, impact on quality of life, and medication satisfaction of sumatriptan/naproxen sodium in the acute treatment of migraine headache in adolescents.Methods.— This 12‐month, multicenter, open‐label, safety study was conducted in adolescents (aged 12‐17 years) with an average of 2‐8 migraines/month typically lasting >2 hours untreated for >6 months prior to initiation. Subjects were instructed to treat migraines as early as possible and were allowed to rescue 2 hours post dose with a single dose of a naproxen‐containing product, over‐the‐counter pain reliever, or anti‐emetics. Subjects were advised not to take a second tablet of sumatriptan/naproxen sodium without at least a 24‐hour headache‐free period. Safety evaluations included adverse events, laboratory tests, and vital signs and electrocardiogram evaluation. Other evaluations included freedom from pain, quality of life, and medication satisfaction.Results.— Of the 656 subjects enrolled, 622 (95%) treated at least 1 migraine with sumatriptan/naproxen sodium, of which 435 (70%) and 363 (58%) completed 6 and 12 months of the study, respectively. Overall, there were 12,927 exposures to sumatriptan/naproxen sodium: on average 2.5 tablets were taken per month per subject. The most common treatment‐related adverse events were nausea (7%), dizziness (3%), muscle tightness (3%), and chest discomfort (3%). There were no deaths; 4 subjects had 5 serious adverse events (suicide attempt, hemolytic anemia and syncope, suicidal ideation, spontaneous abortion) unrelated to sumatriptan/naproxen sodium and resolved without sequelae. Seven percent of subjects discontinued participation in the study because of an adverse event; 5% of subjects discontinued due to lack of efficacy. Overall, 42% of the migraine attacks were pain‐free within 2 hours of treatment with sumatriptan/naproxen sodium, subjects reported improvements from baseline in 2 of 3 quality of life domains over time, and were generally satisfied with the efficacy and overall treatment at the end of the study.Conclusion.— In adolescent migraineurs, after up to 12 months and over 12,000 exposures to sumatriptan/naproxen sodium, there were no new or clinically significant findings in the safety parameters, including the frequency and nature of adverse events, as compared to the individual components or to the adverse event profile in adults. In addition, sumatriptan/naproxen sodium provided freedom from pain over time, improvements in quality of life and medication satisfaction.
The Point Prevalence of Dizziness or Vertigo in Migraine – and Factors That Influence Presentation
Authors: Calhoun Anne H. , Ford Sutapa , Pruitt Amy P. , Fisher Karen G. 
Published: July 2011

Objective.— To ascertain and characterize the point prevalence of dizziness or vertigo in migraineurs presenting for routine appointments at a specialty headache clinic.Background.— Migraine, dizziness, and vertigo are all common in the general population, affecting 13%, 20‐30%, and 5‐10% respectively. Thereby, chance concurrence of migraine with either dizziness or vertigo would be expected in roughly 4% of the general population. It is the authors' clinical impression that severe attacks of migraine are far more commonly associated with these complaints than chance would predict.Methods.— This is a prospective, cross‐sectional study of 462 consecutive patients who presented for consultation at a specialty headache clinic over a 4‐month period of time. During routine check‐in procedures, patients were asked to report their headache pain on a 1‐10 Likert scale. Patients were also asked to report if they were currently experiencing dizziness or vertigo. Responses to these questions were recorded along with vital signs. Diagnosis of migraine with or without aura was made by headache medicine specialists in accordance with International Classification of Headache Disorders – second edition criteria. Chi‐square analysis was used to examine the prevalence of vertigo or dizziness in subjects with varying intensity of headache, and by history of aura.Results.— Of the 425 evaluable subjects, 28% experienced aura. Subjects' average age was 43.8 years (range 15 to 76 years); 89.5% were female. At the time of evaluation, 72.4% of subjects reported some degree of ongoing headache pain and 15.7% reported concurrent dizziness or vertigo. The prevalence of dizziness or vertigo was twice as high (24.5% vs 12.1%) in migraine with aura compared to migraine without aura (P < .01), and prevalence increased with age (P < .05). There was a strong correlation between migraine pain and subjective complaint of vertigo (P < .001). When migraine pain was present at an intensity of 7 or greater (on a scale of 1‐10), almost half of the subjects (47.5%) reported concomitant dizziness or vertigo.Conclusions.— Subjective complaints of dizziness or vertigo appear to be relatively common accompaniments of migraine, particularly migraine with aura, and prevalence increases with age. Disequilibrium symptoms have a strong and positive association with the severity of migraine pain. With co‐occurrence higher than expected by chance, the relationship either reflects comorbidity or these symptoms may be part of the migraine presentation. With a point prevalence of 15.7%, and factors that link expression both to the intensity of migraine pain and to migraine aura, the authors believe that the true relationship may prove to be the latter.
Translation of an Evidence‐Based Social Skills Intervention for Children with Prenatal Alcohol Exposure in a Community Mental Health Setting
Authors: O’Connor Mary J. , Laugeson Elizabeth A. , Mogil Catherine , Lowe Evy , Welch‐Torres Kathleen , Keil Vivien , Paley Blair 
Published: July 2011

Background: Children with prenatal alcohol exposure (PAE) have significant social skills deficits and are often treated in community mental health settings. However, it remains unclear whether these children can be effectively treated using manualized, evidence‐based interventions that have been designed for more general mental health populations.Methods: To shed light on this issue, the effectiveness of Children’s Friendship Training (CFT) versus Standard of Care (SOC) was assessed for 85 children ages 6 to 12 years with and without PAE in a community mental health center.Results: Children participating in CFT showed significantly improved knowledge of appropriate social skills, improved self‐concept, and improvements in parent‐reported social skills compared to children in the SOC condition. Moreover, results revealed that within the CFT condition, children with PAE performed as well as children without PAE. Findings indicated that CFT, an evidence‐based social skills intervention, yielded greater gains than a community SOC social skills intervention and was equally effective for children with PAE as for those without PAE.Conclusions: Results suggest that children with PAE can benefit from treatments initiated in community settings in which therapists are trained to understand their unique developmental needs, and that they can be successfully integrated into treatment protocols that include children without PAE.
Pharmacodynamic Effects of Intravenous Alcohol on Hepatic and Gonadal Hormones: Influence of Age and Sex
Authors: Vatsalya Vatsalya , Issa Julnar E. , Hommer Daniel W. , Ramchandani Vijay A. 
Published: July 2011

Background:  Growth hormone (GH)–insulin‐like growth factor‐1 (IGF‐1) axis and gonadal hormones demonstrate extensively associated regulation; however, little is known about the effects of acute alcohol exposure on these hormones. This study examined the effects of intravenous alcohol on the GH–IGF‐1 axis and gonadal hormone concentrations, and the influence of age and sex on their regulation.
Methods:  Forty‐eight healthy volunteers (24 men and 24 women each in the 21 to 25 and 55 to 65 year age groups) underwent a 2‐session single‐blinded study. Subjects received in randomized counter‐balanced order, alcohol infusions, individually computed based on a physiologically based pharmacokinetic model, to maintain a steady‐state (“clamped”) exposure of 50 mg% or saline for 3 hours in separate sessions. Blood samples collected at baseline and postinfusion in each session were assayed for levels of GH, IGF‐1, free testosterone, and estradiol.
Results:  Acute alcohol administration resulted in changes in gonadal hormones that differed by sex. Change in free testosterone showed a significant treatment × baseline interaction (p < 0.001), indicating that alcohol‐induced suppression of testosterone occurred predominantly in men. On the other hand, change in estradiol showed a significant treatment × sex interaction (p = 0.028), indicating that alcohol‐induced increases in estradiol occurred predominantly in women. There was a trend for alcohol‐induced decreases in IGF‐1 levels. Change in GH showed a significant main effect of baseline (p < 0.001) and a trend for treatment by baseline interaction, suggesting an alcohol‐induced decrease in individuals with high baseline GH values. There was also a significant main effect of sex (p = 0.046) indicating that men had greater changes in GH across treatment compared with women.
Conclusions:  Alcohol induced a complex pattern of hormonal responses that varied between younger and older men and women. Some of the observed sex‐based differences may help improve our understanding of the greater susceptibility to alcohol‐related hepatic damage seen in women.
External Validation of an Index to Predict Up to 9‐Year Mortality of Community‐Dwelling Adults Aged 65 and Older
Authors: Schonberg Mara A. , Davis Roger B. , McCarthy Ellen P. , Marcantonio Edward R. 
Published: July 2011

OBJECTIVES: To further validate an index predicting mortality in community‐dwelling older adults.DESIGN: A comparison of the performance of the index in predicting mortality among new respondents to the National Health Interview Survey (NHIS, 2001–2004) with that of respondents from the original development and validation cohorts (1997–2000) and a test of its performance over extended follow‐up (up to 9 years) using the original cohorts. Follow‐up mortality data were available through 2006.SETTING: NHIS.PARTICIPANTS: Twenty‐two thousand fifty‐seven new respondents to the NHIS (2001–2004) and 24,139 respondents from the original development and validation cohorts (1997–2000).MEASUREMENTS: A risk score was calculated for each respondent based on the presence or absence of 11 factors (function, illnesses, behaviors, demographics) that make up the index. Using the Kaplan‐Meier method, 5‐year mortality estimates were computed for the new and original cohort respondents and 9‐year mortality estimates for the original cohorts.RESULTS: New respondents were similar to original cohort respondents but were slightly more likely to be aged 85 and older, report diabetes mellitus, and have a body mass index of 25.0 kg/m2 or greater. The model performed as well in the new cohort as it had in the original cohort. New respondents with risk scores of 0 to 1 had a 2% risk of 5‐year mortality, whereas respondents who scored 18 or higher had a 69% risk of 5‐year mortality (range 3–71% risk of 5‐year mortality in the development cohort). The index also demonstrated excellent calibration and discrimination in predicting 9‐year mortality (range 7% risk for scores of 0–1 to 92% risk for scores of ≥18, original validation cohort extended).CONCLUSION: These results further justify use of this index to estimate life expectancy in clinical decision‐making.
Diffusion Processes of Product Meanings in Design‐Intensive Industries: Determinants and Dynamics*
Authors: Dell'Era Claudio , Verganti Roberto 
Published: July 2011

Literature on the diffusion of innovation (DoI) is particularly rich and articulated and has been a topic of practical and academic interest since the 1960s. Empirical research in this field has focused on new technologies and managerial practices. However, given the increasingly important role played by design in today's business and academic arenas, we must verify the validity of otherwise robust results obtained largely from tech‐based industries with studies from design‐intensive industries. This paper aims to identify the factors (or determinants) that impact the diffusion dynamics of product meanings within the Italian furniture industry. In particular, we have identified three groups of determinants (innovator marketing strategy, innovator characteristics, and competitive environment), and we have conceptualized diffusion dynamics along two dimensions with their corresponding variables (Speed, Contagion). We have analyzed more than 5,600 products proposed on the market between 1995 and 2006 by 215 furniture manufacturers operating within seven compartments (kitchen, upholstery, lighting, living, chairs, tables, and night). The article discusses 82 diffusion processes of new product meanings.Our results, which were obtained using linear regression analysis, enrich a broad literature on the diffusion of innovation, focusing on design‐intensive industries. Diffusion processes that are activated by several companies are able to influence several manufacturers, and they spread very quickly (Collaboration). Companies concentrating their offerings on only a few product meanings are able to rapidly penetrate the market, proposing clear product identities (Focalization). Reputation does not impact Speed and Contagion, as new product meanings have the opportunity to significantly impact the market but only in cases where well‐known companies have participated in the diffusion process since the beginning and have done so in collaboration with small proactive companies; otherwise, the new meanings remain confined to a market niche phenomenon. Collaboration with several creative resources (System Openness) allows a company to seize dominant trends and improve its capacity to strongly influence the rest of the market. Our empirical results show that launching new product meanings in years when several proposals already exist negatively impacts the possibility of influencing other manufacturers (Ferment). From a managerial point of view, providing variables that characterize the early stages of diffusion processes (i.e., that determine their dynamics) allows our empirical results to be interpreted as forecasting suggestions. This paper provides managers with new guidelines for forecasting the evolution of a product meaning in light of the characteristics of the innovators, the marketing strategies employed, and the competitive environment associated with its launch.
Do Mobile Phones Pose a Potential Risk to Autonomic Modulation of the Heart?
Authors: BARUTCU IRFAN , ESEN ALI METIN , KAYA DAYIMI , TURKMEN MUHSIN , KARAKAYA OSMAN , SAGLAM MUSTAFA , MELEK MEHMET , ÇELİK ATAÇ , KİLİT CELAL , ONRAT ERSEL , KIRMA CEVAT 
Published: July 2011

Background:
It has long been speculated that mobile phones may interact with the cardiac devices and thereby cardiovascular system may be a potential target for the electromagnetic fields emitted by the mobile phones. Therefore, the present study was designed to test possible effects of radiofrequency waves emitted by digital mobile phones on cardiac autonomic modulation by short‐time heart rate variability (HRV) analysis.
Methods and Results:
A total of 20 healthy young subjects were included to the study. All participants were rested in supine position at least for 15 minutes on a comfortable bed, and then time and frequency domain HRV parameters were recorded at baseline in supine position for 5 minutes. After completion of baseline records, by using a mobile GSM (Global System for Mobile Communication) phone, HRV parameters were recorded at turned off mode, at turned on mode, and at calling mode over 5 minutes periods for each stage.
Conclusion:
Neither time nor frequency domain HRV parameters altered significantly during off mode compare to their baseline values. Also, neither time nor frequency domain HRV parameters altered significantly during turned on and calling mode compared to their baseline values. Short‐time exposure to electromagnetic fields emitted by mobile phone does not affect cardiac autonomic modulation in healthy subjects. (PACE 2011; 34:1511–1514)
Prognostic Value of Exercise‐Induced Ventricular Arrhythmia in Chagas’ Heart Disease
Authors: PEDROSA ROBERTO COURY , SALLES JOSÉ HUGO GAMEIRO , MAGNANINI MONICA M. F. , BEZERRA DANIEL C. , BLOCH KATIA VERGETTI 
Published: July 2011

Objective:
To determine the prevalence and the prognostic value of exercise‐induced ventricular arrhythmia (EIVA) in chronic Chagas’ heart disease.
Study Design and Setting:
An open prospective cohort of 130 clinically stable patients at a University Hospital outpatient unit in Rio de Janeiro, Brazil, was followed up at scheduled clinical visits from 1990 through 2007. The endpoint was total cardiovascular mortality. Survival curves (Kaplan‐Meier) and a multivariate Cox proportional hazard model were adjusted to determine the association between EIVA and mortality.
Results:
The median duration of follow‐up was 9.9 years (range, 132 days to 17 years). EIVA prevalence was 43.1% (95% CI: 34.5–51.7). Thirty‐three cardiovascular deaths (25.4%) occurred. The hazard ratio of EIVA for cardiovascular death, after adjustment for age, was 1.84 (P = 0.09). An interaction was found between EIVA and cardiomegaly on x‐ray. In the group with cardiomegaly, the hazard of dying was four times greater in the presence of EIVA (P for interaction = 0.05).
Conclusion:
In clinically stable chagasic subjects with cardiomegaly, EIVA is a clinically significant marker of total cardiovascular mortality and may be a useful risk stratification tool in this population. (PACE 2011; 34:1492–1497)