bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antioxidant and antimicrobial characteristics of mangosteen peel extract and synergistic capacity in beef burger preservation
Authors: Nguyen Khanh Thi Phuong , Nguyen Nguyen Hoang Khoa , Vu Linh Tran Khanh , Le Ngoc Lieu 
Published: June 2024

SummaryThis study aimed to investigate the efficiency of mangosteen peel extract (MPE) in preservation of beef burgers. MPE was first evaluated for its total phenolic content (TPC), total flavonoid content (TFC) and antioxidant and antimicrobial activities. Subsequently, beef burgers were prepared with different MPE amounts (0–1%) and stored for 1 day, 3 days and 5 days. The synthetic antioxidant 2,6‐di‐tert‐butyl‐4‐methyl phenol (BHT) and synthetic antimicrobial sodium benzoate (SB) were used for comparison. The changes of burgers in physicochemical parameters (moisture, cooking loss, storage loss and pH), lipid and protein oxidation (peroxide value, PV; thiobarbituric acid reactive substances, TBARS and carbonyl content), microbiological (total viable count, TVC) and sensory characteristics were assessed. The results revealed that MPE contained a high TPC of 128.93 mg gallic acid equivalent g−1 dry extract and TFC of 62.98 mg rutin equivalent g−1 dry extract. These bioactive compounds rendered MPE with its antioxidant activity approximately equivalent to ascorbic acid and antimicrobial activities against Escherichia coli and Staphylococcus aureus comparable with SB. MPE‐combined burger samples had higher moisture and cooking loss (P < 0.05) but almost equal storage loss and pH value compared with the control samples (P > 0.05). However, the incorporation of MPE into beef burgers did not affect the sensory attributes and preferences of consumers (P > 0.05). The burger with 1% MPE had lower values of PV, TBARS and carbonyl content than all other samples (P < 0.05), including the one added with BHT, indicating the strong potential of MPE as natural antioxidant alternative to prevent the oxidation of lipids and proteins. Through the TVC test, 1% MPE was demonstrated to result in the safe preservation of burgers up to 5 days of storage, equivalent to SB (P > 0.05). Therefore, MPE could become a natural synergistic alternative to both synthetic antioxidant and antimicrobial in the preservation of meat and meat products.
More personal, but not better: The personalization effect in learning neutral and aversive health information
Authors: Almeida Luciana Maria Cavichioli Gomes , Münzer Stefan , Kühl Tim 
Published: June 2024

AbstractBackgroundAccording to the personalization effect in multimedia learning, the use of personal and possessive pronouns in instructional materials (e.g., ‘you’ and ‘your’) is beneficial. However, current research suggests that the personalization effect is inverted for emotionally aversive content (e.g., illnesses).ObjectiveThis study investigates whether a beneficial personalization effect can be observed for emotionally neutral health‐related content whereas the effect may be reversed for emotionally aversive health‐related content.MethodsIn this study, 139 university students learned both emotionally aversive learning content on type 1 diabetes (within‐factor) that was presented in either personalized or non‐personalized language (between‐factor). The presentation order of the content (neutral first vs. aversive first) was controlled (between‐factor), resulting in a 2 × 2 × 2 mixed design. The dependent variables measured include learning outcomes (regarding retention and transfer), state anxiety, extraneous cognitive load, motivation and learning time.Results and ConclusionsIn the transfer test, learners generally performed better when learning with non‐personalized instructional materials than with personalized instructional materials, regardless of whether the content was emotionally neutral or aversive. The results raise questions regarding the robustness of the personalization effect and the underlying mechanisms of the inverted personalization effect. An alternative explanation to be investigated is whether the direct reference to a disease that the participants do not have (here: ‘your type 1 diabetes’) leads to schema interference, which could be responsible for poorer learning performance—even if the learning content about the disease can be considered emotionally neutral.
The quality of prospective mathematics teachers' dynamic geometry tasks in terms of the coordination between mathematical depth levels and technological actions
Authors: Ulusoy Fadime , Girit‐Yildiz Dilek 
Published: June 2024

AbstractBackgroundTeachers must have the skills to find, select, design and use technology‐based mathematical activities that focus on high‐level cognitive demands—supporting student reasoning. However, they experience various difficulties in creating, planning and making decisions about how and when to utilize technological affordances.ObjectivesThis study aims to examine the quality of prospective school mathematics teachers' (PMTs) tasks containing the use of dynamic geometry software through the analysis of the coordination between mathematical depth levels (MDLs) and technological actions (TAs), according to Trocki and Hollebrands', Digital Experiences in Mathematics Education, 2018, 4, 110–138, Dynamic Geometry Task Analysis Framework.MethodsWithin groups, PMTs designed lesson plans that included dynamic geometry tasks (DGTs) based on the learning outcomes of the middle school mathematics curriculum. They then created micro‐teachings of these tasks. The participants' DGTs and transcripts of their microteaching videos were the main data sources.ResultsWe found that many prompts included no TA or a single TA, regardless of the prompts' MDLs. Moreover, the results showed that the high‐depth prompts aimed to contribute to students' reasoning processes on geometric concepts through the TAs, which required specific tools such as dragging and sliding to get generalizations. Although the groups differed in the quality and number of DGTs, the groups' lesson plans mostly contained low‐ or medium‐quality DGTs regarding the coordination between MDLs and TAs.ConclusionsInforming PMTs about high‐quality technology tasks and increasing their awareness on this matter is a priority to encourage them to incorporate innovative technological activities in their mathematics instruction.
Exploring the mechanisms of glycolytic genes involvement in pulmonary arterial hypertension through integrative bioinformatics analysis
Authors: Lou Yu‐xuan , Shi Er‐dan , Yang Rong , Yang Yang 
Published: June 2024

AbstractThe purpose of this study was to identify the mechanisms underlying the involvement of glycolytic genes in pulmonary arterial hypertension (PAH). This study involved downloading 3 datasets from the GEO database at the National Center for Biotechnology Information. The datasets were processed to obtain expression matrices for analysis. Genes involved in glycolysis‐related pathways were obtained, and genes related to glycolysis were selected based on significant differences in expression. Gene Ontology functional annotation analysis, Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis, and GSEA enrichment analysis were performed on the DEGs. Combining LASSO regression with SVM‐RFE machine learning technology, a PAH risk prediction model based on glycolysis related gene expression was constructed, and CIBERSORTx technology was used to analyse the immune cell composition of PAH patients. Gene enrichment analysis revealed that the DEGs work synergistically across multiple biological pathways. A total of 6 key glycolysis‐related genes were selected using LASSO regression and SVM. A bar plot was constructed to evaluate the weights of the key genes and predict the risk of PAH. The clinical application value and predictive accuracy of the model were assessed. Immunological feature analysis revealed significant correlations between key glycolysis‐related genes and the abundances of different immune cell types. The glycolysis genes (ACSS2, ALAS2, ALDH3A1, ADOC3, NT5E, and TALDO1) identified in this study play important roles in the development of pulmonary arterial hypertension, providing new evidence for the involvement of glycolysis in PAH.
Do systemic amoxicillin and metronidazole during the non‐surgical peri‐implantitis treatment phase prevent the need for future surgical treatment? A retrospective long‐term cohort study
Authors: Hakkers Jarno , Vangsted Tine E. , van Winkelhoff Arie Jan , de Waal Yvonne C. M. 
Published: June 2024

AbstractAimThe aim of this retrospective long‐term follow‐up of a 3‐month RCT was to assess whether non‐surgical peri‐implantitis treatment with adjunctive systemic antibiotics influenced the need for additional surgical treatment.Materials and MethodsPatients enrolled in an aftercare programme following non‐surgical peri‐implantitis treatment, with or without systemic amoxicillin and metronidazole, were analysed. Data had previously been collected pre‐treatment (T0) and 3 months after treatment (T1) and were additionally collected during subsequent aftercare visits, until the final assessment (T2). Primary outcome was the need for additional surgical peri‐implantitis therapy during the aftercare programme, analysed via Kaplan–Meier analysis and Cox regression. Secondary outcomes involved clinical parameters, assessed using parametric and non‐parametric tests.ResultsForty‐five patients (22 AB− group, 23 AB+ group) were included. The mean follow‐up time between T1 and T2 was 35.9 months (SD = 21.0). 73.9% of the AB+ group and 50.0% of the AB− group did not receive additional surgical therapy (log‐rank test, p = .110). The adjusted Cox regression model did not provide a significant result for antibiotics (β = .441, 95% CI = 0.159–1.220, p = .115). Univariable regression analysis highlighted the influence of baseline peri‐implant pocket depth on the need for surgical treatment (β = 1.446, 95% CI = 1.035–2.020, p = .031).ConclusionsSystemic amoxicillin and metronidazole administered during non‐surgical peri‐implantitis treatment do not seem to prevent the need for additional surgical therapy in the long term, during a structured aftercare programme.
A review of flash‐floods management: From hydrological modeling to crisis management
Authors: Sadkou Salma , Artigue Guillaume , Fréalle Noémie , Ayral Pierre‐Alain , Pistre Séverin , Sauvagnargues Sophie , Johannet Anne 
Published: June 2024

AbstractIn a context of climate change, flash‐floods are expected to increase in frequency. Considering their devastating impacts, it is primordial to safeguard the exposed population and infrastructure. This is the responsibility of crisis managers but they face difficulties due to the rapidity of these events. The focus of this study was to characterize the extent of the link between hydrologists and crisis managers. It also aimed to determine the limiting and the fostering factors to an effective integration of forecasting in crisis management during flash‐floods. This was achieved through an extensive and methodological study of available literature in selected platforms. The models encountered were characterized on multiple levels including the physical, geographical and crisis management level. The results revealed a limited link between the two involved parties with limiting factors such as the complexity of the modeling approach, the insufficient projection in the implications of operationality of the models proposed and the financial aspect. On the other hand, acknowledging the threat of flash‐floods and conducting cost–benefit‐analysis were pinpointed as fostering factors. This study showed to reconsider the forecasting methods employed, particularly, the integration of machine learning, and the needs of end‐user in these applications in a crisis management context.
Natural mycobacterium tuberculosis complex infection in a brown howler monkey (Alouatta guariba clamitans) in Brazil
Authors: de Souza Endily Vasconcelos , Réssio Rodrigo Albergaria , Figueiredo Ketlyn Bolsachini , de Carvalho Ana Carolina Souza Ramos , Ferreira‐Machado Eduardo , de Carvalho Júlia , dos Santos Cirqueira Cinthya , Navas‐Suárez Pedro Enrique , Zwarg Ticiana , Ritter Jana M. , de Azevedo Fernandes Natália Coelho Couto , Guerra Juliana Mariotti 
Published: June 2024

AbstractNeotropical primates rarely exhibit active tuberculosis. A brown howler monkey was found injured in an urban area. Histopathology revealed granulomatous inflammation in the lungs, lymph nodes, and liver. Immunohistochemistry and molecular analysis confirmed the presence of Mycobacterium tuberculosis complex. The findings highlight the importance of TB surveillance in nonhuman primates.
Fabrication and efficacy assessment of combination of brimonidine and ivermectin for treatment of papulopustular rosacea
Authors: Pakdaman Samin Fallah , Samadi Aniseh , Fattahi Mahsa , Naeimifar Atefeh , Ardehali Fatemeh Amiri , Ketabi Yasaman , Nasrollahi Saman Ahmad , Firooz Alireza 
Published: June 2024

AbstractBackground & AimRosacea is a chronic inflammatory, multifactorial disease for which combination therapy could be an effective treatment.In this study, we evaluate the effect of the combination therapy of brimonidine 0.33% and ivermectin 1% as a single cream for the treatment of papulopustular rosacea.MethodA stable and appropriate formulation was prepared by adding the aqueous phase to the lipid phase while being stirred. The stability and physicochemical properties of the formulation were evaluated under accelerated conditions. Twelve patients (36–60 years) with mild to moderate papulopustular rosacea and a Demodex count of five or more were treated with the combination of brimonidine 0.33% and ivermectin 1% cream. Clinician's Erythema Assessment (CEA), Patients Self‐Assessment (PSA), skin erythema (ΔE) and lightness (ΔL), and skin biophysical parameters including transepidermal water loss (TEWL), skin hydration, pH, and sebum content, as well as erythema and melanin index and ultrasound parameters, were measured before treatment and 4 and 8 weeks after. Adverse drug reactions were also recorded.ResultsCEA and PSA decreased significantly from 3 to 2 after 8 weeks, respectively (p‐value = 0.014 for CEA and 0.010 for PSA). ΔE and ΔL, as well as skin erythema index and TEWL improved after 8 weeks of treatment (p < 0.05). Two patients withdrew from the study in the first week because of local adverse effects; one developed flushing following treatment and left the investigation after 4 weeks and another patient withdrew from the study after 4 weeks due to deciding to become pregnant.ConclusionEight‐week treatment with the combination of brimonidine 0.33% and ivermectin 1% was shown to be effective for improvement of erythema and inflammatory lesions in mild to moderate papulopustular rosacea.
Topical moisturizer with rose stem cell‐derived exosomes (RSCEs) for recalcitrant seborrheic dermatitis: A case report with 6 months of follow‐up
Authors: Lueangarun Suparuj , Cho Byong Seung , Tempark Therdpong 
Published: June 2024

AbstractIntroductionSeborrheic dermatitis (SD) poses significant treatment challenges due to its chronic nature and the side effects associated with long‐term use of conventional therapies like topical corticosteroids. In the search for alternative treatments, exosomes, particularly those derived from rose stem cells (RSCEs), offer a promising avenue due to their potential in managing chronic skin conditions.ObjectiveThis case report examines the efficacy of a topical moisturizer containing RSCEs in treating a patient with refractory SD, aiming to provide an alternative treatment pathway.Materials and MethodsA 40‐year‐old male with a long‐standing history of SD, unresponsive to traditional treatments, underwent a novel treatment regimen. This regimen included an initial topical application of 2.5 mL of RSCEs followed by a maintenance phase involving the application of a RSCE‐containing moisturizer. Clinical outcomes were assessed through the Patient's Global Assessment (PGA) and Investigator's Global Assessment (IGA) scores, along with evaluations of scaling and erythema.ResultsRemarkable clinical improvement was noted as early as 1‐day post‐treatment, with significant reductions in redness, scaling, and itching. The patient experienced sustained relief throughout the 6‐month follow‐up, with a recurrence in the sixth month that was less severe than previous flare‐ups. This demonstrated not only the efficacy of RSCEs in symptom management but also their potential in extending remission periods.ConclusionThe chronic management of SD can benefit from innovative treatments like the RSCE‐containing moisturizer, as shown in this case report. While the observed outcomes are promising, indicating substantial improvements in skin condition and symptom management, larger controlled studies are necessary to validate the therapeutic potential of exosome‐containing moisturizers fully. This case underscores the need for alternative therapies in SD treatment, highlighting the role of exosomes as a viable option.
Cut‐off value for anti‐Müllerian hormone in the diagnostic criteria for polycystic ovary syndrome in the Japanese population
Authors: Noguchi Hiroki , Iwasa Takeshi , Iwase Akira , Kanasaki Haruhiko , Kimura Fuminori , Kugu Koji , Saito Kazuki , Baba Tsuyoshi , Hara Tetsuaki , Matsuzaki Toshiya 
Published: June 2024

AbstractAimTo establish cut‐off values for anti‐Müllerian hormone (AMH) and antral follicle count (AFC) in the diagnostic criteria for polycystic ovary syndrome (PCOS) applicable to the Japan Society of Obstetrics and Gynecology (JSOG) 2024 criteria and the Rotterdam/International Evidence‐Based Guideline for the assessment and management of PCOS (IEBG) 2023 criteria based on a nationwide survey, respectively, taking into account age, assays, and structure of the diagnostic criteria.MethodsData were collected for 986 PCOS cases and 965 control cases using a national survey in Japan and used to establish cut‐off values for AMH and AFC.ResultsSerum AMH levels were significantly higher in the PCOS group compared to the control group. Serum AMH showed a significant negative correlation with age and significant positive correlation with AFC in both groups. In multiple regression analysis, serum AMH level was independently affected by AFC and total testosterone. AMH cut‐off values suitable for the JSOG 2024 criteria and the Rotterdam/IEBG 2023 criteria were separately established for the 20–29 and 30–39 years of age groups, respectively, and for Access, Lumipulse and Elecsys/ECLusys, respectively. AFC cut‐off values suitable for the JSOG 2024 criteria and Rotterdam/IEBG 2023 criteria were also established separately. AFC exhibited statistically greater variability than AMH.ConclusionThe serum AMH level is the biochemical representation of ovarian findings in PCOS and considered objective and highly reliable. Therefore, it could serve as a surrogate for AFC as a marker of polycystic ovarian morphology in diagnostic criteria.
Bidirectional associations between periodontitis and inflammatory bowel disease: A systematic review of longitudinal studies with meta‐analysis and trial sequential analysis
Authors: Wang Qiuhao , Chen Shuze , Zhou Jieyu , Zhao Lei 
Published: June 2024

AbstractThe bidirectional associations between periodontitis and inflammatory bowel disease (IBD) with temporal directionality remain inconclusive. This study aims to evaluate the bidirectional associations between periodontitis and IBD through a systematic review and meta‐analysis. Five databases (PubMed, Embase, Web of Science, Scopus and Cochrane Library) were systematically searched from inception to 27 February 2024. Two independent reviewers performed a review of the retrieved studies. Longitudinal studies, including cohort and nested case–control studies, were considered eligible for the study design. The pooled risk ratio (RR) and hazard ratio (HR) derived from the meta‐analysis were used to assess whether periodontitis (or IBD) was a risk factor for IBD (or periodontitis). Trial sequential analysis (TSA) was performed to evaluate the reliability of the results. Four studies (n = 10 270 912) on the risk of IBD in patients with periodontitis and two (n = 33 420) on the risk of periodontitis in patients with IBD were included. The result suggested that periodontitis did not increase the risk of IBD (pooled RR = 1.04, 95% confidence interval [CI]: 0.99–1.09; p = .164; I‐squared statistic [I2] = 27%). For subtypes of IBD, periodontitis was associated with the occurrence of ulcerative colitis (UC) (pooled RR = 1.12, 95% CI: 1.04–1.21; p = .003; I2 = 38%), but not with Crohn's disease (CD) (pooled RR = 0.98, 95% CI: 0.92–1.04; p = .475; I2 = 0%). Specifically, the risk of UC was higher among men (pooled HR = 1.11, 95% CI: 1.01–1.22; p = .025; I2 = 0%) and smokers (pooled HR = 1.23, 95% CI: 1.07–1.42; p = .004; I2 = 0%) with periodontitis than their counterparts without periodontitis. Patients with IBD may have a higher risk of developing periodontitis (pooled HR = 1.37, 95% CI: 1.26–1.49; p < .001; I2 = 18%); however, whether IBD subtypes increased the occurrence of periodontitis remained uncertain. The TSA results confirmed the reliability of the primary findings. Based on limited longitudinal evidence, patients with periodontitis do not exhibit an increased risk of developing IBD overall, but they are at increased risk of UC (not CD). On the contrary, patients with IBD have a higher risk of developing periodontitis over time. More high‐quality longitudinal studies are needed to determine the effect of specific subtypes of IBD on periodontitis.
Short apneas and periodic breathing in preterm infants in the neonatal intensive care unit—Effects of sleep position, sleep state, and age
Authors: Plunkett Georgina , Yiallourou Stephanie , Voigt Aimee , Segumohamed Aishah , Shepherd Kelsee , Horne Rosemary , Wong Flora 
Published: June 2024

SummaryThis observational study investigated the effects of sleep position and sleep state on short apneas and periodic breathing in hospitalized preterm infants longitudinally, in relation to postmenstrual age. Preterm infants (25–31 weeks gestation, n = 29) were studied fortnightly after birth until discharge, in prone and supine positions, and in quiet sleep and active sleep. The percentage of time spent in each sleep state (percentage of time in quiet sleep and percentage of time in active sleep), percentage of total sleep time spent in short apneas and periodic breathing, respectively, the percentage of falls from baseline in heart rate, arterial oxygen saturation and cerebral tissue oxygenation index during short apneas and periodic breathing, and the associated percentage of total sleep time with systemic (arterial oxygen saturation < 90%) and cerebral hypoxia (cerebral tissue oxygenation index < 55%) were analysed using a linear mixed model. Results showed that the prone position decreased (improved) the percentage of falls from baseline in arterial oxygen saturation during both short apneas and periodic breathing, decreased the proportion of infants with periodic breathing and the periodic breathing‐associated percentage of total sleep time with cerebral hypoxia. The percentage of time in quiet sleep was higher in the prone position. Quiet sleep decreased the percentage of total sleep time spent in short apneas, the short apneas‐associated percentage of falls from baseline in heart rate, arterial oxygen saturation, and proportion of infants with systemic hypoxia. Quiet sleep also decreased the proportion of infants with periodic breathing and percentage of total sleep time with cerebral hypoxia. The effects of sleep position and sleep state were not related to postmenstrual age. In summary, when sleep state is controlled for, the prone sleeping position has some benefits during both short apneas and periodic breathing. Quiet sleep improves cardiorespiratory stability and is increased in the prone position at the expense of active sleep, which is critical for brain maturation. This evidence should be considered in positioning preterm infants.