bluuebunny/crossref_metadata_2025_split huggingface dataset:
Co‐occurrence of rhino‐orbital mucormycosis and acute lymphoblastic leukemia post‐COVID‐19 infection in a young adolescent male: A case report from a low middle‐income country
Authors: Lingarapu Maneesha , Shaikh Bisma , Singh Ajeet , Khan Mustafa Ahmed , Oduoye Malik Olatunde , Kamboj Nancy , Danishwar Mahmood 
Published: May 2024

Key Clinical MessageImmunosuppression from B‐acute lymphoblastic leukemia (B‐ALL) chemotherapy and a preceding COVID‐19 infection may predispose patients to rare complications such as rhino‐orbital mucormycosis. Hence, a high index of suspicion should be maintained by physicians (and oncologists) if patients undergoing B‐ALL treatment present with orofacial symptoms and ophthalmological manifestations such as peri‐orbital swelling, ophthalmoplegia, and loss of vision, suggestive of infection.AbstractMucormycosis is a severe fungal infection that poses significant mortality and morbidity risks, particularly in immunocompromised individuals. We present a rare case of a 16‐year‐old patient with rhino‐orbital mucormycosis following B‐acute lymphoblastic leukemia (B‐ALL) treatment and concurrent COVID‐19 infection. We describe the clinical presentation, diagnosis, treatment, and outcome of this patient, and discuss the possible interactions and implications of these three conditions. A young 16‐year‐old male patient without significant clinical history was admitted with complaints of low‐grade intermittent fever, fatigue, malaise, restlessness, and unexplained weight loss for the past 2 months. A bone marrow biopsy confirmed the diagnosis of B‐ALL. Following the diagnosis of B‐ALL, the patient underwent initiation of chemotherapy. Following the initial two cycles of chemotherapy, the patient experienced fever and cough and tested positive for COVID‐19 infection. Nearly a week later, the patient presented to the chemotherapy emergency department with a clinical picture characterized by a fever up to 39°C associated with left facial swelling, severe headache, purulent rhinorrhea, and foreign body sensation in the ipsilateral nostril. The following day, erythema and left eyelid edema were observed, with ocular opening limitation. The diagnosis was confirmed based on the positive result of polymerase chain reaction for left‐sided mucormycosis. Initial administration of liposomal and lipid amphotericin B at 1–1.5 mg/kg/d doses for 4–6 weeks was followed by surgical debridement of necrotic tissue on the left side of the face and nose. Subsequent ophthalmological examinations showed normal conditions of the left eye. The case underscores the importance of heightened clinical suspicion, early diagnosis through imaging and molecular techniques, aggressive multimodal therapy, and close interdisciplinary collaboration for improved outcomes in such rare and challenging clinical scenarios.
Exceedingly rare incidence of a double inferior vena cava (IVC) with azygos continuation of left IVC
Authors: Dadkhah Adeleh , Pasha Saeed Akbarzadeh , Amin Borjian Mohammad 
Published: May 2024

Key Clinical MessageBecause of the complex embryonic origin of the abdominal venous structures, IVC and azygous systems can show numerous and even previously unreported anatomical variations and anomalies. Also, evaluating major vascular structures should not be dismissed in non‐contrast‐enhanced CT as it can provide valuable information about these structures.AbstractDouble IVC is a rare occurrence of IVC anatomical variations and congenital anomalies. Herein, we discuss a case of a very rare type of double IVC that has not been reported in the literature before. A non‐contrast‐enhanced CT study was performed for a 34‐year‐old patient who visited our ER to evaluate for urolithiasis, during which two IVCs were noted. Each renal vein joined the ipsilateral IVC at a perpendicular angle. Unusually, the right IVC was formed from the confluence of both left and right common iliac veins (CIV), and the left IVC—Instead of crossing the midline at the renal veins level and reuniting the right IVC—cranially contributed to the azygos vein formation and caudally joined the left CIV. Also, there were some small communicating veins between the two IVCs and the left gonadal vein was slightly dilated before suggesting a reflux from the left renal vein (LRV). A complimentary doppler ultrasound exam confirmed the diagnosis and revealed a left‐side varicocele. Although rare cases of hemiazygos continuation and interiliac connections of left‐side IVC in the cases of double‐IVC have been reported previously, a complete confluence of CIVs is rare. The main differential diagnosis is retro‐aortic left renal vein (RLRV) type IV which seems to have an oblique course. Radiologists and surgeons should expect previously unreported variations in the vena cava system. Furthermore, reviewing the main abdominal vasculature should not be dismissed in non‐contrast CT exams.
Antiaromaticity of Cycloheptatrienyl Anions: Structure, Acidity, and Magnetic Properties
Authors: Salikov Rinat F. , Belyy Alexander Y. , Ilyushchenko Matvey K. , Platonov Dmitry N. , Sokolova Alena D. , Tomilov Yury V. 
Published: May 2024

AbstractInvestigations of the nature and degree of antiaromaticity of cycloheptatrienyl anion derivatives using both experimental and computational tools are presented. The ground state of cycloheptatrienyl anion in the gas phase is triplet, planar and Baird‐aromatic. In DMSO, it assumes a singlet distorted allylic form with a paratropic ring current. The other derivatives in both phases assume either allylic or diallylic conformations depending on the substituent pattern. A combination of experimental and computational methods was used to determine the pKa values of 16 derivatives in DMSO, which ranged from 36 to −10.7. We revealed that the stronger stabilization of the anionic system, which correlates with acidity, does not necessarily imply a lower degree of antiaromaticity in terms of magnetic properties. Conversely, the substitution pattern first affects the geometry of the ring through the bulkiness of the substituents and their better conjugation with a more distorted system. Consequently, the distortion reduces the cyclic conjugation in the π‐system and thereby decreases the paratropic current in a magnetic field, which manifests itself as a decrease in the NICS. The triplet‐state geometries and magnetic properties are nearly independent on the substitution pattern, which is typical for simple aromatic systems.
An Investigation on Linker Modifications of Cyanoguanidine‐Based P2X7 Receptor Antagonists
Authors: Garrett Taylor R. , Gilchrist Jayson , McKenzie Andre D. J. , Larik Fayaz Ali , Danon Jonathan J. , Werry Eryn L. , Kassiou Michael 
Published: May 2024

AbstractDespite their acknowledged significance in the inflammatory signalling cascade across a range of disease states, P2X7R antagonists have not yet proven to be effective in clinical trials. In this study, we present findings on P2X7 receptor antagonists that are based on a core adamantyl‐cyanoguanidine‐quinoline lead. To investigate the specific features of the cyanoguanidine moiety that influence compound potency we carried out a structure‐activity relationship (SAR) study. Compound potency was assessed using an in vitro dye‐uptake assay measuring P2X7R pore formation. While none of the compounds displayed superior potency to the lead, we established key structural requirements for potent P2X7R antagonism. An additional SAR using different aryl groups was performed based on the promising activity displayed by the squaramide derivative.
Detoxification of Chemical Warfare Agents by a Zr‐Based MOF with High Recycling Ability at Physiological pH
Authors: Biswas Subharanjan , Gay Rémy , Bzdrenga Janek , Soirot Thomas , Belverge Nicolas , Taudon Nicolas , Brazzolotto Xavier , Haouas Mohamed , Steunou Nathalie , Mahy Jean‐Pierre , Ricoux Rémy 
Published: May 2024

AbstractThe neutralization of organophosphorous (OP) chemical agents used in modern warfare is a growing concern due to their extreme toxicity to human cells. In several previous works, although the capability of several Zr‐MOF‐based catalysts has been showcased to facilitate hydrolysis of OP agents in heterogeneous pathways, their usage appeared to be limited by very slow kinetics at neutral pH. There is still a lack of MOF based catalysts that can detoxify OPs at physiological pH. The recycling ability of MOF‐based catalysts has also not been greatly explored. Thus, herein, we explored a Zr‐based MOF, MOF‐801(Zr) for the detoxification of a series of OP nerve agents and a pesticide with simultaneous adsorption and degradation at pH 7.5 in a buffer solution, close to physiological conditions. This MOF‐based catalyst demonstrates significant hydrolysis activity towards several nerve agents, with up to 99 % conversion within 2 h and an excellent half‐life of less than 5 minutes. In addition, it can be recycled at least 5 times consecutively with a residual activity of at least 90 %.
‘The Relentless Nature of Whiteness’: Black Psychologists' Experiences of Racial Microaggressions in Cross‐Cultural Supervision
Authors: Ebubedike Ngozi , Callanan Margie , Oldershaw Anna 
Published: May 2024

ABSTRACTObjectivesResearch suggests that cross‐cultural supervision can be prone to microaggressions with deleterious effects for ethno‐racial minorities. There are currently no known studies examining the impact of racial microaggressions in supervision on qualified psychologists. This study aimed to explore Black psychologists' experiences of microaggressions in supervision with a White supervisor and their impact.MethodsSemi‐structured interviews were conducted with 10 individuals who had completed clinical or counselling psychology doctoral training. Interviews were transcribed and analysed using interpretative phenomenological analysis.ResultsThree superordinate themes and 12 subthemes were derived from the analysis. The superordinate themes were: ‘It's the subtle things’, ‘It's an ordeal’ and ‘Surviving Whiteness in psychology’. The findings illustrate the complex nature of racial microaggressions and their profound and lasting impact on individuals. The cumulative impact of these experiences resulted in significant negative psychological outcomes.ConclusionsThe results suggest that there are common microaggressions that recur in supervision. Encountering microaggressions impeded the supervisory relationship, supervision and professional development. Clinical implications include recommendations for including multicultural competency in psychology trainings and ongoing professional development plans.
Constructing and Preliminary Testing a Narrative Therapy Programme for Posttraumatic Growth in Chinese Patients With Inflammatory Bowel Disease—A Pilot Study
Authors: Chen Dandan , Zhu Tianrong , Zhou Yunxian 
Published: May 2024

ABSTRACTBackgroundThe research on posttraumatic growth (PTG) promotion programmes, particularly narrative therapy (NT), for patients with inflammatory bowel disease (IBD) remains limited. This pilot study aims to develop an NT programme to promote PTG and evaluate its feasibility, preliminary effectiveness, participants' experiences and improvement suggestions.MethodsThe NT programme was initially developed through literature review, interviews with IBD patients and expert panel discussions. A randomized controlled pilot trial was conducted to assess the feasibility and preliminary effectiveness of the programme. Participants in the NT group received five consecutive weekly sessions of the programme, while the control group received standard care. Outcomes including PTG, anxiety, depression and quality of life were measured. Qualitative interviews were conducted to explore participants' experiences and suggestions for programme modifications.ResultsThe NT programme was developed with scientific rigour. The recruitment rate and retention rate were 62.5% and 96.7%, respectively. A significant reduction in anxiety levels was observed, and manifestations of PTG were reported in the NT group. Suggestions for improvement of the NT programme were received from the participants.ConclusionThe NT programme was constructed to promote PTG in IBD patients in this study, further offering preliminary evidence for its feasibility and potential positive psychological change. However, large‐scale research is needed to validate its effectiveness for broader applications.
Controllable Afterglow Emission of Single‐Mode to Dual‐Mode Carbon Dot Composites through Matrix Ratio Adjustment
Authors: Zhang Kunsheng , Huang Shengyao , Gao Jingran , Tang Limei , He Rongxing , Li Ming , Shen Wei 
Published: May 2024

AbstractRoom temperature afterglow materials have received widespread attention and application in anti‐counterfeiting, imaging, and other fields, but the many shortcomings of traditional afterglow materials in terms of cost, environment, and synthesis methods have limited their development. In contrast, carbon dot materials have attracted more and more research due to their numerous advantages and great potential for development. However, the preparation of carbon dot materials with phosphorescence and delayed fluorescence afterglow emission capabilities remains a difficult task. In this study, a series of long life afterglow carbon dot composites with single‐mode and dual‐mode afterglow emission were successfully prepared by inserting carbon dots synthesized from glucose and glycine into boric acid matrix through a two‐step hydrothermal method. This series of carbon dot composites has achieved a transformation from single‐mode phosphorescent emission to unique dual‐mode afterglow emission, allowing for efficient environmental response color modulation. The composites display different afterglow emissions dominated by either phosphorescent or delayed fluorescence at different temperatures. Based on their excellent temperature sensitivity, a single‐mode long phosphorescence with a lifetime of 1.62 seconds was achieved at low temperature. In summary, we have discovered a convenient and efficient method to achieve dual‐mode emission by adjusting the matrix proportion.
Controlled Self‐Assembly of Zn‐Tetraphenylporphyrins for Efficient Photocatalytic Solar H2 Production and Simultaneous Organic Transformation to Valuable Chemicals
Authors: Sury Adhra , Samuthirapandi Kiruthika , Ghosh Soham , Kar Subhajit , Sarkar Sunandan , Kommula Bramhaiah , Bhattacharyya Santanu 
Published: May 2024

AbstractHerein, we have designed aqueous dispersed self‐assembled nanostructures with diverse morphologies from the zinc tetraphenyl porphyrin (ZnTPP) monomer employing simple solution‐based coprecipitation methods. Detailed morphological studies have been carried out by various electron microscopy techniques. Finally, the structural features were correlated with the underpinning photophysical processes using steady‐state and time‐resolved spectroscopy. Detailed studies suggest that controlled morphology and highly defined intermolecular interactions affect the overall photoinduced charge transfer process. Based on the fundamental investigations, all these different types of nanostructures have been utilized as photocatalysts for solar hydrogen production without using any cocatalysts, and it was found that the spherical nanostructure exhibits significantly higher H2 production rates of ∼1682 μ mole/g, which is a few folds higher than other 1D and 2D nanostructured materials. The experimental findings were further supported by the TD‐DFT study. Furthermore, the detailed computational studies suggest that the spherical aggregates exhibited a more vital interaction between the ZnTPP molecules, causing significant electronic coupling between bright local excited and charge transfer states, which supports our experimental findings. Finally, we have selectively utilized the oxidative half‐reaction for the simultaneous transformation of glycerol to valuable chemicals along with photocatalytic H2 production through reductive half‐reaction.
Growing Small Grains in Sub‐Arctic Alaska
Authors: Joosse Tess 
Published: May 2024

Abstract
The largest state in the U.S., Alaska has only 1% of its land devoted to agriculture. Yet, there’s a strong need for and interest in increasing local production to help fortify food security in the state.
The Alaska Collaborative Food Production Systems Project develops research projects and supports agricultural producers in the state.
At the 2023 ASA, CSSA, and SSSA Annual Meeting, researchers from the team talked about the project’s objectives and progress. With one growing season under their belts, they’ve made headway on breeding trials, gathered novel data on soil health and quality, finished a year of cover crop trials, and interviewed producers and consumers about food agency in the state.
An investigation of the impact of imbalance on the analysis of the US crop variety evaluation program data
Authors: Fang Zhou , Deng Dewayne D. , Jenkins Johnie N. , Zhou Qian M. 
Published: May 2024

AbstractMulti‐environment trial data from many crop variety evaluation programs are imbalanced because only a subset of varieties is selected for the following year, which leads to missing variety by year. Inspired by the US National Cotton Variety Test trial, we conducted new simulation studies to investigate selection processes that differ from the existing literature. The followings are our four main contributions. First, we adopted a framework that utilizes a logistic regression to generate imbalanced data that follow missing completely at random, missing at random, or missing not at random (MNAR). Second, our selection process can depend on multiple traits, whereas all existing studies only used a single trait for selection. Third, besides variance components (VCs), long‐term trends that reflect genetic and non‐genetic development are of interest since the simulated data span over 30 years. Last, we evaluated the prediction accuracy for variety's overall and location‐specific performance. The results show that the VC and long‐term trends estimations are the worst under MNAR using the single trait for selection. Compared to VC, the long‐term trends estimation is more influenced by the missing mechanism and missing rate. However, the prediction accuracy for variety's performance is mainly driven by the missing rate and is less sensitive to the selection process. If ignoring the genetic and non‐genetic long‐term trends, both estimation and prediction will deteriorate. More testing years would improve estimation and prediction, despite a higher missing rate.
Non‐Fused π‐Extension of Endcaps of Small Molecular Acceptors Enabling High‐Performance Organic Solar Cells
Authors: Feng Fan , Hu Zunyuan , Wang Jianxiao , Wang Pengchao , Sun Cheng , Wang Xiaoning , Bi Fuzhen , Li Yonghai , Bao Xichang 
Published: May 2024

AbstractThe modular structure of small molecular acceptors (SMAs) allows for versatile modifications of the materials and boosts the photovoltaic efficiencies of organic solar cells (OSCs) in recent years. As a critical component, the endcaps of SMAs have been intensively investigated and modified to control the molecular aggregation and photo‐electronic conversion. However, most of the studies focus on halogenation or π‐fusion extension of the endcap moieties, but overlook the non‐fused π‐extension approach, which could be a promising strategy to balance the self‐aggregation and compatibility behaviors. Herein, we reported two new acceptors namely BTP‐Th and BTP‐FTh based on non‐fused π‐extension of the endcap by chlorinated‐thiophene, of which the latter molecule has better co‐planarity and crystallinity because of the intramolecular noncovalent interactions. Paired with donor PBDB‐T, the optimal device of BTP‐FTh reveals a greater efficiency of 14.81 % that that of BTP‐Th (13.91 %). Nevertheless, the BTP‐Th based device realizes a lower energy loss, enabling BTP‐Th as a good candidate to serve as guest acceptor. As a result, the ternary solar cells of PM6 : BTP‐eC9 : BTP‐Th output a champion efficiency up to 18.71 % with enhanced open‐circuit voltage. This study highlights the significance of rational decoration of endcaps for the design of high‐performance SMAs and photovoltaic cells.
Engineered CAR‐T cells targeting the non‐functional P2X purinoceptor 7 (P2X7) receptor as a novel treatment for ovarian cancer
Authors: Bandara Veronika , Niktaras Victoria M , Willett Vasiliki J , Chapman Hayley , Lokman Noor A , Macpherson Anne M , Napoli Silvana , Gundsambuu Batjargal , Foeng Jade , Sadlon Timothy J , Coombs Justin , McColl Shaun R , Barry Simon C , Oehler Martin K , Ricciardelli Carmela 
Published: May 2024

AbstractObjectivesRecent studies have identified expression of the non‐functional P2X7 (nfP2X7) receptor on various malignant cells including ovarian cancer, but not on normal cells, which makes it a promising tumour‐associated antigen candidate for chimeric antigen receptor (CAR)‐T‐cell immunotherapies. In this study, we assessed the cytotoxic effects of nfP2X7‐CAR‐T cells on ovarian cancer using in vitro and in vivo models.MethodsWe evaluated the effects of nfP2X7‐CAR‐T cells on ovarian cancer cell lines (SKOV‐3, OVCAR3, OVCAR5), normal peritoneal cells (LP‐9) and primary serous ovarian cancer cells derived from patient ascites in vitro using monolayer and 3D spheroid assays. We also evaluated the effects of nfP2X7‐CAR‐T cells on patient‐derived tissue explants, which recapitulate an intact tumour microenvironment. In addition, we investigated the effect of nfP2X7‐CAR‐T cells in vivo using the OVCAR‐3 xenograft model in NOD‐scid IL2Rγnull (NSG) mice.ResultsOur study found that nfP2X7‐CAR‐T cells were cytotoxic and significantly inhibited survival of OVCAR3, OVCAR5 and primary serous ovarian cancer cells compared with un‐transduced CD3+ T cells in vitro. However, no significant effects of nfP2X7‐CAR‐T cells were observed for SKOV3 or normal peritoneal cells (LP‐9) cells with low P2X7 receptor expression. Treatment with nfP2X7‐CAR‐T cells increased apoptosis compared with un‐transduced T cells in patient‐derived explants and correlated with CD3 positivity. Treatment with nfP2X7‐CAR‐T cells significantly reduced OVCAR3 tumour burden in mice compared with un‐transduced CD3 cells for 7–8 weeks.ConclusionThis study demonstrates that nfP2X7‐CAR‐T cells have great potential to be developed as a novel immunotherapy for ovarian cancer.