bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ternary Cocrystal with Long‐Lived Charge‐Transfer State for Efficient Light Conversion Applications
Authors: Xiao Yejun , Liu Lifang , Xu Peng , Sun Fengke , Li Feng , Liu Xuan , Yin Yanfeng , Leng Jing , Zhang Fuxiang , Jin Shengye 
Published: April 2024

AbstractCharge‐transfer (CT) cocrystals have attracted continuous interest for their promising optical and optoelectronic applications. To improve the performance of this class of material, a CT cocrystal with long‐lived CT excitons is highly desired. Herein, the development of a pyrene‐doped trans‐1,2‐diphenylethylene‐1,2,4,5‐tetracyanobenzene ternary cocrystal (named P‐TS‐TC) is reported. Compared to the undoped binary cocrystals (without pyrene), P‐TS‐TC exhibits a two times longer CT exciton lifetime (≈60.2 ns), and thus 8.8‐ and 16.6‐times improvement in photocurrent response and photocatalytic H2 evolution activity. By using transient photoluminescence spectroscopy, it is uncovered that the absorbed photon energy in P‐TS‐TC is localized to a lower energy CT state through an efficient energy transfer process (≈389.8 ps) between two co‐existing CT states. The CT exciton lifetime is prolonged due to the weakened CT coupling strength, as a result of the enlarged donor‐acceptor distance and the change of geometric structure. The result is expected to inspire the design of cocrystals with manipulatable CT exciton properties and to promote the potential application of multi‐component CT cocrystals.
Cropland soil nitrogen oxide emissions vary with dairy manure incorporation methods
Authors: Miller David J. , Chai Jiajue , Guo Felix , Ponce de León María A. , Ryals Rebecca , Dell Curtis J. , Karsten Heather , Hastings Meredith G. 
Published: April 2024

AbstractSoils contribute 15%–75% of total atmospheric nitrogen oxide (NOx) emissions in agricultural regions during the growing season. However, the impacts of cropland fertilizer management on spatially heterogeneous, temporally episodic NOx emission patterns are highly uncertain. We examine the effects of liquid slurry dairy manure application practices on soil NOx emissions in rainfed, corn‐soybean rotations during spring 2016 and 2017. Daily soil NOx emissions and weekly soil inorganic N measurements were performed in a randomized split–split plot design for 1–4 weeks following manure applications. NOx emissions and soil N with shallow‐disk injection and chisel‐disk manure incorporation methods were compared with unincorporated broadcast practices. Injected manure and chisel‐disk incorporation exhibited two–four times larger mean NOx emissions than those with unincorporated broadcast manure. Larger soil NOx emissions with manure incorporation practices were driven by the predominance of nitrification in these treatments with evidence of soil nitrate production. Soil NOx emission differences between treatments were detectable across order of magnitude changes in daily NOx emissions during two growing seasons. Larger soil NOx emissions associated with manure incorporation practices compared with unincorporated broadcast practices occur alongside larger N2O and smaller NH3 emissions, highlighting important air quality and climate impact tradeoffs for cropland manure fertilizer management choices.
The interplay of psychosis and non‐compliance with fatal outcome in an adult with MSUD
Authors: Falah Nadia , Pendyal Surekha , Sasannejad Cina , Gibson Allison , Lee Yu Lin , McDonald Marie , Koeberl Dwight 
Published: April 2024

AbstractSignificant progress has been achieved in enhancing early outcomes for individuals with maple syrup urine disease (MSUD), a rare metabolic disorder that leads to the accumulation of branched‐chain amino acids leucine, isoleucine, and valine, where leucine is known as the primary neurotoxic metabolite. Newborn screening is helpful in early diagnosis and implementation of dietary treatment, thus reducing neurological deterioration and complications in young children. However, patients face the life‐long challenge of maintaining metabolic control through adherence to a strict low‐leucine diet to avoid long‐term consequences of chronic hyperleucinemia, which include cognitive deficits, mood disorders, and movement disorders. This case report exemplifies the complex involvement of MSUD in adult survivors. Despite presenting early in life, the patient thrived until the onset of psychiatric symptoms. The subject of this case is a 25‐year‐old woman with MSUD, who remained in her usual state of health until presentation to the emergency department (ED) with psychosis and altered mental status. However, due to a lack of medical records and poor communication, there was a delay in considering MSUD as a primary cause of her psychiatric symptoms. Although a genetics consultation was later arranged and efforts were made to decrease plasma leucine to the therapeutic range, these interventions proved inadequate in halting her deterioration in health. Her condition worsened within 72 h, culminating in her untimely death. This case emphasizes the comorbidity of psychiatric involvement in MSUD, which contributes to metabolic decompensation that can lead to cerebral edema and death. This case also highlights the pressing need for enhanced strategies for the acute management and long‐term care of MSUD patients with psychiatric involvement, particularly in scenarios where mental disturbance could lead to noncompliance.
A novel AP1S2 variant causing leaky splicing in X‐linked intellectual disability: Further delineation and intrafamilial variability
Authors: Noojarern Saisuda , Tim‐Aroon Thipwimol , Anurat Kingthong , Phetthong Tim , Khongkraparn Arthaporn , Wattanasirichaigoon Duangrurdee 
Published: April 2024

AbstractPettigrew syndrome (PGS), an X‐linked intellectual disability (XLID), is caused by mutations in the AP1S2 gene. Herein, we described a Thai family with six patients who had severe‐to‐profound intellectual impairment, limited verbal communication, and varying degrees of limb spasticity. One patient had a unilateral cataract. We demonstrated facial evolution over time, namely coarse facies, long faces, and thick lip vermilions. We identified a novel AP1S2 variant, c.1‐2A>G. The mRNA analysis revealed that the variant resulted in splicing defects with leaky splicing, yielding two distinct aberrant transcripts, one of which likely resulting in the mutant protein lacking the first 44 amino acids whereas the other possibly leading to no production of the protein. By performing a literature review, we found 51 patients and 11 AP1S2 pathogenic alleles described and that all the variants were loss‐of‐function alleles. The severity of ID in Pettigrew syndrome is mostly severe‐to‐profound (54.8%), followed by moderate (26.2%) and mild. Progressive spasticity was noted in multiple patients. In summary, leaky splicing found in the present family was likely related to the intrafamilial clinical variability. Our data also support the previous notion of variable expression and neuroprogressive nature of the disorder.
Rhodium‐Catalyzed Direct ortho‐Arylation of Anilines
Authors: Jacob Clément , Annibaletto Julien , Peng Ju , Bai Ruopeng , Maes Bert U. W. , Lan Yu , Evano Gwilherm 
Published: April 2024

AbstractAn efficient and broadly applicable rhodium‐catalyzed direct ortho‐arylation of anilines with aryl iodides relying on readily available aminophosphines as traceless directing groups is reported. Its scope and functional group compatibility were both found to be quite broad as a large variety of both aminophosphines and (hetero)aryl iodides, including complex ones, could be utilized. The ortho‐arylated anilines could be obtained in high average yields, without any competing diarylation and with full regioselectivity, which constitutes a major step forward compared to other processes. The reaction is moreover not limited to aryl iodides, as an aryl bromide and a triflate could be successfully used, and could be extended to diarylation. Mechanistic studies revealed the key and unique role of the aminophosphine, acting not only as a substrate but also as a ligand for the rhodium catalyst.
Coupling Nano and Atomic Electric Field Confinement for Robust Alkaline Oxygen Evolution
Authors: Wang Qiyou , Gong Yujie , Zi Xin , Gan Lei , Pensa Evangelina , Liu Yuxiang , Xiao Yusen , Li Hongmei , Liu Kang , Fu Junwei , Liu Jun , Stefancu Andrei , Cai Chao , Chen Shanyong , Zhang Shiguo , Lu Ying‐Rui , Chan Ting‐Shan , Ma Chao , Cao Xueying , Cortés Emiliano , Liu Min 
Published: April 2024

AbstractThe alkaline oxygen evolution reaction (OER) is a promising avenue for producing clean fuels and storing intermittent energy. However, challenges such as excessive OH− consumption and strong adsorption of oxygen‐containing intermediates hinder the development of alkaline OER. In this study, we propose a cooperative strategy by leveraging both nano‐scale and atomically local electric fields for alkaline OER, demonstrated through the synthesis of Mn single atom doped CoP nanoneedles (Mn SA‐CoP NNs). Finite element method simulations and density functional theory calculations predict that the nano‐scale local electric field enriches OH− around the catalyst surface, while the atomically local electric field improves *O desorption. Experimental validation using in situ attenuated total reflection infrared and Raman spectroscopy confirms the effectiveness of the nano‐scale and atomically electric fields. Mn SA‐CoP NNs exhibit an ultra‐low overpotential of 189 mV at 10 mA cm−2 and stable operation over 100 hours at ~100 mA cm−2 during alkaline OER. This innovative strategy provides new insights for enhancing catalyst performance in energy conversion reactions.
Carbon Free Radical (R⋅) Inactivates NF‐κB for Radical Capping Therapy
Authors: Zhao Peiran , Li Huiyan , Sun Bingxia , Wang Chaochao , Lv Guanglei , Chen Chao , Ying Leilei , He Xinhong , Jin Dayong , Bu Wenbo 
Published: April 2024

AbstractInactivating hyperactivated transcription factors can overcome tumor therapy resistance, but their undruggable features limit the development of conventional inhibitors. Here, we report that carbon‐centered free radicals (R⋅) can inactivate NF‐κB transcription by capping the active sites in both NF‐κB and DNA. We construct a type of thermosensitive R⋅ initiator loaded amphiphilic nano‐micelles to facilitate intracellular delivery of R⋅. At a temperature of 43 °C, the generated R⋅ engage in electrophilic radical addition towards double bonds in nucleotide bases, and simultaneously cap the sulfhydryl residues in NF‐κB through radical chain reaction. As a result, both NF‐κB nuclear translocation and NF‐κB‐DNA binding are suppressed, leading to a remarkable NF‐κB inhibition of up to 94.1 %. We have further applied R⋅ micelles in a clinical radiofrequency ablation tumor therapy model, showing remarkable NF‐κB inactivation and consequently tumor metastasis inhibition. Radical capping strategy not only provides a method to solve the heat‐sink effect in clinic tumor hyperthermia, but also suggests a new perspective for controllable modification of biomacromolecules in cancer therapy.
Mechanochemical Cyclotrimerization: A Versatile Tool to Covalent Organic Frameworks with Tunable Stacking Mode
Authors: Hutsch Stefanie , Leonard Allison , Grätz Sven , Höfler Mark Valentin , Gutmann Torsten , Borchardt Lars 
Published: April 2024

AbstractWe introduce the first mechanochemical cyclotrimerization of nitriles, a facile strategy for synthesizing triazine‐containing molecules and materials, overcoming challenges related to carbonization and solubility. Conducting this solid‐state approach in a mixer ball mill with 4‐Methylbenzonitrile, we synthesize Tris(4‐methylphenyl)‐1,3,5‐triazine quantitatively in as little as 90 minutes. Just as fast, this mechanochemical method facilitates the synthesis of the covalent triazine framework CTF‐1 using 1,4 Dicyanobenzene. Material characterization confirms its porous (650 m2 g−1) and crystalline nature. Adjusting the induced mechanical energy allows control over the obtained stacking conformation of the resulting CTFs ‐ from a staggered AB arrangement to an eclipsed AA stacking conformation. Finally, a substrate scope demonstrates the versatility of this approach, successfully yielding various CTFs.
Design and Synthesis of C4‐Symmetric Axially Chiral β‐Aryl Porphyrins and Application for Supporting Ir(III)‐Catalyzed Enantioselective C−H Alkylation
Authors: Yuan Shanshan , Sun Jun‐Chao , Zhao Xiao‐Ming , Zhu Jieping , Zheng Sheng‐Cai 
Published: April 2024

AbstractA hitherto unknown class of C4‐symmetric Caryl−Cβ (C3, C8, C13, C18) axially chiral porphyrins has been synthesized and the application of their iridium (Ir) complexes in catalytic asymmetric C(sp3)−H functionalization is documented. Cyclotetramerization of enantioenriched axially chiral 2‐hydroxymethyl‐3‐naphthyl pyrroles under mild acidic conditions affords, after oxidation with 2,3‐dichloro‐5,6‐dicyano‐1,4‐benzoquinone (DDQ), the C4‐symmetric α,α,α,α‐atropenantiomer as an only isolable diastereomer. Both regioisomeric Ir(Por*)(CO)(Cl) complexes catalyze the carbene C−H insertion reaction affording the same enantiomer, albeit with slight difference in enantioselectivity. With the optimum Ir‐complex 3 e, the 2‐substituted arylacetic acid derivatives were generated from diazo compounds and cyclohexadiene in excellent yields and enantioselectivities.
Photo‐induced organo‐manganese‐mediated radical polymerization of acrylates under LED irradiation
Authors: Pesqueira Naralyne M. , Lira Kathia H. , Bignardi Camila , da Silva Milene K. C. , Silva Thiago F. , Machado Antonio E. H. , Nascimento Otaciro R. , Carvalho‐Jr Valdemiro P. , Goi Beatriz E. 
Published: April 2024

The role of manganese in photo‐induced organometallic‐mediated radical polymerization (photo‐OMRP) under LED (light‐emitting diode) irradiation has not been previously explored. In this study, four manganese (II) complexes, namely [Mn(6‐tert‐butyl‐N,N′‐propanebis [salicylimine])] (Mn‐Bu), [Mn(6,3‐di‐tert‐butyl‐N,N′‐propanebis [salicylimine])] (Mn‐Bu2), [Mn(6‐ethoxy‐N,N′‐propanebis [salicylimine])] (Mn‐Ethoxy), and [Mn(6,3‐di‐ethoxy‐N,N′‐propanebis [salicylimine])] (Mn‐Ethoxy2), were synthesized using both symmetrical and non‐symmetrical tetradentate N2O2 Schiff base ligands. The Schiff base ligands were characterized by Fourier transform infrared spectroscopy (FTIR), ultraviolet–visible spectroscopy (UV–Vis), and nuclear magnetic resonance spectroscopy (NMR). The Mn (II) complexes were characterized by FTIR, UV–Vis, elemental analysis, molar conductivity, cyclic voltammetry, MALDI‐TOF mass spectrometry, electron paramagnetic resonance, and rationalized with density functional theory (DFT) studies. All complexes were evaluated as photo‐OMRP mediators under LED irradiation at 390 nm and in the 400–800 nm range. The photopolymerization utilized methyl acrylate (MA) and diphenyl(2,4,6‐trimethylbenzoyl)phosphine oxide (TPO) in varying molar ratios of [MA]/[MnII]/[TPO] (900/1/1, 600/1/1, and 600/1/0.5). The photo‐OMRP of MA mediated by Mn‐Bu2 showed the best control over molecular weight (Mn matching Mn,th) and dispersity (Ð < 1.30) at a [MA]/[MnII]/[TPO] = 600/1/0.5 M ratio. The polymerization system demonstrated a living character, as evidenced by reversible “on/off” light source switching. Furthermore, a block copolymer of poly (methyl acrylate)‐b‐poly (butyl acrylate) was successfully synthesized employing a sequential visible‐light‐induced process, with the Mn‐Bu2 system showing the best results.
Stabilization of oil‐in‐water emulsion gels by pH‐induced electrostatic interactions between soybean protein isolate microgel particles and xanthan gum
Authors: Mao Jixian , Cui Lujie , Meng Zong 
Published: April 2024

AbstractIn this paper, a colloidal dispersion at different pH containing soybean protein isolate (SPI) microgel particles and xanthan gum (XG) was used as the aqueous phase to prepare O/W emulsion gels with soybean oil. Properties of SPI microgel particles were analyzed by particle size, Zeta‐potential, secondary structure, optical contact angle, dynamic interface tension, and SEM testing, respectively. Results showed that pH impact microgels particle size and Zeta‐potential and their emulsification properties. It turned out that only at pH 3, 6, 7, and 8 can construct emulsions successfully. Based on a comparison of microstructure and macroscopic properties, it was found that at pH 3, proteins and polysaccharides were oppositely charged, electrostatic attraction between them reduced proteins located at the interface, and was more likely to form larger droplets, resulting in a bimodal droplet distribution and larger sizes. Conversely, at the pH of 6, 7, and 8, respectively, emulsions exhibited a uniform droplet distribution and more solid‐like rheological properties due to the powerful electrostatic repulsion between SPI and XG. Also, emulsion gels co‐stabilized with proteins and polysaccharides under electrostatic repulsion conditions showed an ideal recovery ability. Overall, this work would be beneficial to the use of emulsion gels in fat substitute systems.
A reinterpretation of human breast anatomy includes all the layers of the anterior body wall
Authors: Hall Margaret I. , Suarez‐Venot Ana , Lindvall Tyler , Plochocki Jeffrey H. , Grossman Aryeh , Rodriguez‐Sosa Jose R. , Voegele Georgina M. , Valdez Dominik R. , Georgi Justin A. 
Published: April 2024

AbstractMammary glands define mammals as a group, yet a comprehensive anatomical description of the mammary gland does not exist for almost any mammalian species. In humans, the anatomical and surgical literature provide conflicting and incomplete descriptions of the gross anatomy of the breast. We dissected 9 male and 15 female human body donors to clarify this gross anatomy. We found that, like other epidermally derived glands of the body, the mammary glandular tissue is constrained to a membrane‐bound, central structure referred to as the corpus mammae in the surgical literature, and not dispersed throughout the breast as typically described in the anatomical literature. The major fasciae of the human anterior body wall, including the superficial fatty Camper's fascia and the deeper membranous Scarpa's fascia, both contribute to the structure of the breast. This anatomical arrangement suggests that, as the mammary gland invaginates posteriorly from the integument during embryological development, the mammary fat pad most likely derives from Camper's fascia, and growth of Scarpa's fascia around this fat pad forms the anterior and posterior lamellae of the breast pocket. Anteriorly, Scarpa's fascia becomes a double layer that creates the surface structure of the breast. Posteriorly, Scarpa's fascia forms a circummammary ligament that (1) stabilizes the breast against the thoracic wall and (2) is continuous with Scarpa's fascia on the rest of the anterior body wall. The suspensory ligaments of the breast represent the typical retinaculae cuti found consistently throughout the human body wall, and do not directly attach to the skin. Instead, these retinaculae attach to the anterior or posterior lamella of Scarpa's fascia.
New anti‐windup Proportional‐Integral‐Derivative for motor speed control
Authors: Yapp Kevin K. C. , Hoo Choon Lih , Lai Chun Haw 
Published: April 2024

AbstractThe proportional‐integral‐derivative (PID) was developed and recognized for its reliability. A PID controller is not only simple but also relatively cheap. However, the controller causes system performance degeneration over time due to the presence of windup in a motor speed control system. The windup phenomenon is caused by the saturated control state. Various anti‐windup methods were introduced to decrease a system's long settling time and extreme overshooting. Most anti‐windup techniques require integral switching between saturated and unsaturated states, whereby both versions of steady‐state integral proportional‐integral controller do not need integral switching mechanism. They possess a certain degree of decoupling between
and
tuning parameters and tested to allow a more comprehensive range of tuning in the absence of derivative control. This research investigated the impact of derivative control component on the tuning gain decoupling through hardware simulation. By integrating the derivative component,
, the control system demonstrated an improved system stability and reduced overshoot. Result shows that the decoupling feature allows SIPIC01+D and SIPIC02+D controllers to produce performance with zero overshoot and short settling time. However, SIPIC01+D has better dynamical performance with fastest rise and settling time with no overshoot as compared to other anti‐windup controllers.
Triggerable biomaterials‐based osteomyelitis theranostics
Authors: Li Lei , Yin Yue , Zhang Shengchang , Yang Junyuan , Li Pei , Zhou Huaijuan , Li Jinhua 
Published: April 2024

AbstractThe emergence of multidrug‐resistant bacteria poses a significant challenge in the treatment of osteomyelitis, rendering traditional antibiotic treatment strategies inadequate in terms of achieving a complete cure. In recent years, triggerable biomaterial‐based, antibiotic‐free osteomyelitis treatment strategies have rapidly evolved, demonstrating excellent bactericidal effects. Triggerable biomaterials‐based osteomyelitis theranostics encompass physical signal response strategies and host immune modulation approaches. These strategies can be effective against drug‐resistant bacteria, circumventing the gradual acquisition of resistance that often accompanies traditional antibiotic treatment. Additionally, the inherent physical properties of the triggerable biomaterials facilitate the precise imaging of osteomyelitis. There is no doubt that triggerable biomaterial‐mediated, antibiotic‐free therapies are emerging as a trend, which is critically important in combating multidrug‐resistant bacteria‐induced osteomyelitis. In this review, we summarize the latest advances in osteomyelitis treatment strategies from both pathogen‐directed and host‐directed perspectives. The design regimens and specific action mechanisms of triggerable biomaterial‐based nanoplatforms are also clarified. Finally, we outline the challenges faced by various antibiotic‐free therapies and provide an outlook on the prospects for synergistic interactions.
Strategic pathways to achieve Sustainable Development Goal 12 through Industry 4.0: Moderating role of institutional pressure
Authors: Sharma Mahak , Singh Pratibha , Tsagarakis Konstantinos 
Published: April 2024

AbstractEmerging economies, at the vanguard of extensive resource depletion and limited environmental stewardship, are worst‐hit by climate change events, necessitating an extensive investigation of the relevance of I4.0 in attaining sustainable consumption and production patterns. This study focuses on Sustainable Production and Consumption (SDG12) and investigates how the implementation of I4.0 can contribute to the adoption of circular economy practices (CEPs) to incorporate elements of sustainable consumption and procurement into supply chains. Based on dynamic capabilities theory, institutional pressure, and the triple‐bottom‐line perspective, this study proposes an overarching research framework that presents the synergistic convergence of dynamic capabilities, I4.0, and the circular economy to achieve SDG12. This framework is empirically validated through a survey‐based, cross‐sectional research design by utilizing conditional process modeling. This study employed purposive sampling where respondents constituted 480 industry practitioners and professionals in digital supply chain and operations management from manufacturing firms based in the Baddi and Alwar districts in India. The findings demonstrate that I4.0 and CEPs sequentially mediate the impact of dynamic capabilities on SDG12, while mimetic pressure strengthens the impact of exploitation‐oriented strategy on SDG12.