bluuebunny/crossref_metadata_2025_split huggingface dataset:
Field Apparatus for Measurement of Elastic Rebound and Final Set for Driven Pile Capacity Estimation
Authors: Oliveira J. R. M. S. , Nunes P. R. R. L. , Silva M. R. L. , Cabral D. A. , Ferreira A. C. G. , Carneiro L. A. V. , Giraldi M. T. M. R. 
Published: October 2010

AbstractMany advances have been made on driven piles bearing capacity tests, such as the static and dynamic load tests. However, the cost and the time necessary to prepare these kinds of tests usually restrict their application to a small percentage of the piles. Consequently, the simple and low-cost ways to estimate the bearing capacity of driven piles, for instance, through the final set and the elastic rebound, can be used to control the majority of the piles, and then the results can be compared with more complex and accurate tests executed in fewer elements. This paper describes the development of an in situ tool to measure the elastic rebound and the final set without any direct contact with the pile. Afterwards, these values can be used to evaluate the bearing capacity based on the dynamic formulas proposed by many authors. The apparatus was tested in three different sites, with the results very close to those obtained with the conventional elastic rebound and the final set measuring method.
Jumper Kinematics on Terrain Park Jumps: Relationship between Takeoff Speed and Distance Traveled
Authors: Shealy Jasper , Scher Irving , Stepan Lenka , Harley Erin 
Published: October 2010

Abstract
The performance of individuals jumping tabletop features in terrain parks has not been widely studied. A field study was conducted to measure the takeoff speed and horizontal distance achieved by jumpers at two tabletop style jump features: A smaller jump at Snow Summit, CA and a larger jump at Mammoth Mountain, CA, USA. Analyses were also conducted to determine the effects of equipment type (skis versus snowboard) on jumper kinematics. Before each data collection session, the physical dimensions of the jump were measured and recorded. For consecutive jumpers, the speed parallel to the ramp was measured at the end of the takeoff by using a laser speed trap accurate to 0.11 m/s. The landing zone was marked at 3.0 m intervals with colored dye, beginning just past the flat deck portion of the jump. A high-definition video camera was used to record the landing of each jumper, and the landing point of the projected center of mass was determined by using photogrammetry, accurate to within 5 cm. The actual landing distances measured in the field were compared to predicted landing distances by using ordinary ballistic equations. A total of 280 jumps was observed on the two features: 105 on skis and 175 on snowboards. The correlation coefficients between the square of the takeoff speed and the landing distance for the smaller and larger jumps were 0.75 (R2=0.56) and 0.41 (R2=0.16), respectively. The measured landing distances differed significantly from those predicted by models using the ballistic equations of motion. The average landing distance beyond the knuckle was 2.4 m on the smaller jump and 2.1 m on the larger jump. For both features, skier and snowboarder jumpers did not differ in average landing distance.
Parlor Games: Italian Music and Italian Politics in the Parisian Salon
Authors: Smart Mary Ann 
Published: October 2010

Abstract
Among a community of Italian political leaders and artists who settled in Paris after the failed Italian revolutions of 1831 was Count Carlo Pepoli, author of the libretto for Bellini's I puritani. During his years in Paris, Pepoli also wrote the poetry for two song collections: Rossini's Soirées musicales and Mercadante's Soirées italiennes. Both collections are conceived as a series of picturesque images of Italian locales interspersed with pastoral scenes; they are also linked by allusions to a character named Elvira, perhaps a projection of the heroine of I puritani. This article explores the connections between the Rossini and Mercadante songs and their possible link to Bellini's opera, in relation to two distinct audiences: the Parisian salons of the 1830s, with their strong Italian expatriate presence, and the market of amateurs who purchased sheet music. In both contexts, the poetic content and musical style of the songs may have fostered favorable attitudes to Italy and to Unification, showing that even music composed for private and domestic uses could be politically influential.
Differences in the insulin tolerance test in patients with brain damage depending on posture
Authors: Kopczak A , von Rosen F , Krewer C , Schneider H J , Stalla G K , Schneider M 
Published: October 2010

ObjectiveThe insulin tolerance test (ITT) is the gold standard for the diagnosis of GH deficiency (GHD) and hypocortisolism. As hypopituitarism is a common disorder after traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH), the test is increasingly used in patients with pre-existing brain damage.DesignA cross-sectional, observational study.MethodsFifty-six patients (41 TBI and 15 SAH) were tested with the ITT (0.15 IE/kg body weight, mean glucose 33 mg/dl). In 38 patients, the test was performed in a supine position; the other 18 patients were in a sitting position during the ITT.ResultsHypocortisolism and GHD were more often diagnosed in a supine than in a sitting position (hypocortisolism: 55.3% supine versus 0% sitting, P<0.0001; GHD: 42.1% supine versus 11.1% sitting, P=0.03). Patients in a sitting position suffered more often from symptoms such as tachycardia (61.1% sitting versus 15.8% supine, P=0.001), trembling (22.2 vs 7.9%, NS), and sweating (66.7 vs 28.9%, P=0.007). There were no significant differences between the groups in drowsiness (72.2% sitting versus 65.8% supine, NS), dizziness (44.4 vs 44.7%, NS), and fatigue (33.3 vs 15.8%, NS). Because of somnolence, the hypoglycemic state could only be stopped with i.v. administration of glucose in 25 supine patients (66%). In contrast, none of the 18 patients (0%) tested in a sitting position got somnolent or was in need of i.v. application of glucose (P<0.001).ConclusionsIn patients with brain injury, posture might affect rates of diagnosing GHD and hypocortisolism and sympathetic symptoms in the ITT. These findings are exploratory and need replication in a standardized setting.
Glycosylation Genes Expressed in Seam Cells Determine Complex Surface Properties and Bacterial Adhesion to the Cuticle of Caenorhabditis elegans
Authors: Gravato-Nobre Maria J , Stroud Dave , O'Rourke Delia , Darby Creg , Hodgkin Jonathan 
Published: October 2010

Abstract
The surface of the nematode Caenorhabditis elegans is poorly understood but critical for its interactions with the environment and with pathogens. We show here that six genes (bus-2, bus-4, and bus-12, together with the previously cloned srf-3, bus-8, and bus-17) encode proteins predicted to act in surface glycosylation, thereby affecting disease susceptibility, locomotory competence, and sexual recognition. Mutations in all six genes cause resistance to the bacterial pathogen Microbacterium nematophilum, and most of these mutations also affect bacterial adhesion and biofilm formation by Yersinia species, demonstrating that both infection and biofilm formation depend on interaction with complex surface carbohydrates. A new bacterial interaction, involving locomotory inhibition by a strain of Bacillus pumilus, reveals diversity in the surface properties of these mutants. Another biological property—contact recognition of hermaphrodites by males during mating—was also found to be impaired in mutants of all six genes. An important common feature is that all are expressed most strongly in seam cells, rather than in the main hypodermal syncytium, indicating that seam cells play the major role in secreting surface coat and consequently in determining environmental interactions. To test for possible redundancies in gene action, the 15 double mutants for this set of genes were constructed and examined, but no synthetic phenotypes were observed. Comparison of the six genes shows that each has distinctive properties, suggesting that they do not act in a linear pathway.
Socially-Responsive Gene Expression in MaleDrosophila melanogasterIs Influenced by the Sex of the Interacting Partner
Authors: Ellis Lisa L , Carney Ginger E 
Published: October 2010

AbstractBehavior is influenced by an organism's genes and environment, including its interactions with same or opposite sex individuals. Drosophila melanogaster perform innate, yet socially modifiable, courtship behaviors that are sex specific and require rapid integration and response to multiple sensory cues. Furthermore, males must recognize and distinguish other males from female courtship objects. It is likely that perception, integration, and response to sex-specific cues is partially mediated by changes in gene expression. Reasoning that social interactions with members of either sex would impact gene expression, we compared expression profiles in heads of males that courted females, males that interacted with other males, or males that did not interact with another fly. Expression of 281 loci changes when males interact with females, whereas 505 changes occur in response to male–male interactions. Of these genes, 265 are responsive to encounters with either sex and 240 respond specifically to male–male interactions. Interestingly, 16 genes change expression only when a male courts a female, suggesting that these changes are a specific response to male–female courtship interactions. We supported our hypothesis that socially-responsive genes can function in behavior by showing that egghead (egh) expression, which increases during social interactions, is required for robust male-to-female courtship. We predict that analyzing additional socially-responsive genes will give us insight into genes and neural signaling pathways that influence reproductive and other behavioral interactions.
H2A.Z (Htz1) Controls the Cell-Cycle-Dependent Establishment of Transcriptional Silencing at Saccharomyces cerevisiae Telomeres
Authors: Martins-Taylor Kristen , Sharma Upasna , Rozario Tania , Holmes Scott G 
Published: October 2010

Abstract
The establishment of transcriptional silencing in Saccharomyces cerevisiae requires progression through the cell cycle. We have previously found that transit through M-phase is necessary and sufficient to establish silencing at telomeres following induction of the Sir3 silencing factor. In this study we find that halting cell-cycle progression in either G1 or at the beginning of M-phase limits the ability of Sir3 to associate with a telomere-linked reporter gene and prevents the changes in histone modifications associated with gene repression. Deletion of genes coding for the histone variant H2A.Z (Htz1 in yeast) and histone acetyltransferase Sas2 abolish the cell-cycle progression requirement for the establishment of silencing. Cells blocked in telophase (but not at metaphase) are also able to establish silencing. We show that H2A.Z binds to the promoter of our telomere-linked reporter gene and that this binding diminishes in silenced cells. Finally, we observe a specific displacement of H2A.Z from chromatin in telophase-blocked cells, regardless of the silencing status of the reporter gene. These results suggest that the requirement for M-phase in the establishment of silencing may reflect a cell-cycle regulated relaxation of heterochromatin barriers.
Trans-Centromere Effects on Meiotic Recombination in the Zebrafish
Authors: Demarest Bradley L , Horsley Wyatt H , Locke Erin E , Boucher Kenneth , Grunwald David J , Trede Nikolaus S 
Published: October 2010

Abstract
We report that lack of crossover along one chromosome arm is associated with high-frequency occurrence of recombination close to the opposing arm's centromere during zebrafish meiotic recombination. Our data indicate that recombination behavior on the two arms of a chromosome is linked. These results inform mapping strategies for telomeric mutants.
The DNA Polymerase Activity ofSaccharomyces cerevisiaeRev1 is Biologically Significant
Authors: Wiltrout Mary Ellen , Walker Graham C 
Published: October 2010

AbstractA cell's ability to tolerate DNA damage is directly connected to the human development of diseases and cancer. To better understand the processes underlying mutagenesis, we studied the cell's reliance on the potentially error-prone translesion synthesis (TLS), and an error-free, template-switching pathway in Saccharomyces cerevisiae. The primary proteins mediating S. cerevisiae TLS are three DNA polymerases (Pols): Rev1, Pol ζ (Rev3/7), and Pol η (Rad30), all with human homologs. Rev1's noncatalytic role in recruiting other DNA polymerases is known to be important for TLS. However, the biological significance of Rev1's unusual conserved DNA polymerase activity, which inserts dC, is much less well understood. Here, we demonstrate that inactivating Rev1's DNA polymerase function sensitizes cells to both chronic and acute exposure to 4-nitroquinoline-1-oxide (4-NQO) but not to UV or cisplatin. Full Rev1-dependent resistance to 4-NQO, however, also requires the additional Rev1 functions. When error-free tolerance is disrupted through deletion of MMS2, Rev1's catalytic activity is more vital for 4-NQO resistance, possibly explaining why the biological significance of Rev1's catalytic activity has been elusive. In the presence or absence of Mms2-dependent error-free tolerance, the catalytic dead strain of Rev1 exhibits a lower 4-NQO–induced mutation frequency than wild type. Furthermore, Pol ζ, but not Pol η, also contributes to 4-NQO resistance. These results show that Rev1's catalytic activity is important in vivo when the cell has to cope with specific DNA lesions, such as N2-dG.
Part II: Crystalline Fluorapatite-Coated Hydroxyapatite Implant Material: A Dog Study With Histologic Comparison of Osteogenesis Seen With FA-Coated HA Grafting Material Versus HA Controls: Potential Bacteriostatic Effect of Fluoridated HA
Authors: Nordquist William D , Okudera Hajima , Kitamura Yutaka , Kimoto Kazunari , Okudera Toshimitsu , Krutchkoff David J 
Published: October 2010

Abstract
Success of osteogenesis in bone graft procedures can be enhanced by inhibiting oral bacterial infections through the use of prophylactic bacteriostatic fluoride within the grafting environment. Ideally, the fluoride ion should be chemically sequestered and thus unavailable unless needed at times during the process of early infection. As fluoride within fluorapatite is tightly bound at neutral pH and becomes available only during acidic conditions, fluorapatite is an ideal store for the fluoride ion which becomes released for bacteriostasis only during an acidic environment found with incipient bacterial infection. The purpose of this investigation was to compare the histologic properties of new bone formed surrounding fluorapatite (FA)-coated microcrystalline hydroxyapatite (HA) grafting material with comparable bone formed following the use of control HA material (OsteoGen, Impladent, Ltd, Holliswood, NY). The results of histologic analysis within dog studies here showed no detectable difference in new bone following therapeutic grafting procedures using each of the above 2 mineral coatings.
Part III: Crystalline Fluorapatite-Coated Hydroxyapatite; Potential Use as a Bacteriostatic Agent for Both Pre-Implant Cases and Retreatment of Infected Implant Sites: A Report of 4 Cases
Authors: Nordquist William D , Krutchkoff David J 
Published: October 2010

Abstract
Four cases of peri-implant bone loss associated with undiagnosed necrotic pulps of adjacent teeth are reported. In two cases, bone was obliterated along sinus tracts (fistulas) that coursed between the implant and adjacent tooth. Endodontic treatment was completed on the adjacent teeth concurrent with periapical surgery to seal the tooth apex. The sinus tract (fistula) was excised, and the implant plus tooth surfaces were treated with a combination of concentrated citric acid and 4.3% sodium fluoride solutions. The third case involved peri-implant surgery with endodontic treatment on the adjacent tooth. A fourth case represented an infected socket augmentation which was surgically treated, augmented with microcrystalline fluorapatite in the range of a 300 µm to 400 µm cluster, and allowed to heal for 4 months followed by a trephine bone biopsy and subsequent analysis for bone growth around the fluoridated nonceramic microcrystalline hydroxyapatite (HA). An augmentation procedure employing fluoridated of resorbable HA was then completed. Histologic analysis showed healthy bone regeneration suggesting that therapeutic fluoride treatment and resultant fluorapatite were helpful in inhibiting reinfection following surgical treatment. All 4 infected implant sites were successfully managed and retained using the aforementioned treatment schemes, and there was no evidence of posttreatment infection in any of the 4 cases. It is proposed that fluoride treatment, through the use of 4.3% sodium fluoride and/or fluoridated hydroxyapatite (fluorapatite), shows promise as an adjunctive treatment component in inhibiting peri-implant infection and reinfection when managing ailing or failing implants.
Effect of Letrozole on Plasma Lipids, Triglycerides, and Estradiol in Postmenopausal Women with Metastatic Breast Cancer
Authors: Zidan Jamal , Chetver Lika , Hussein Osamah , Zucker Miriam 
Published: October 2010

Abstract

Purpose.
The aromatase inhibitor letrozole effectively treats breast cancer by decreasing estrogen levels in postmenopausal women. The aim of this prospective study was to evaluate the effect of letrozole on plasma lipids, triglyceride lipase (TGL), and estradiol levels in women with metastatic breast cancer (MBC).

Materials and Methods.
Fifty-two postmenopausal women with MBC received letrozole, 2.5 mg/day. Blood samples for assessment of plasma levels of total cholesterol (TC), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, TGL, and estradiol were taken at baseline and after 3, 6, and 12 months of treatment.

Results.
A nonsignificant increase was found in TC and HDL cholesterol levels after 3 months, which returned to baseline levels after 6 months (p = .794 and p = .444, respectively). LDL cholesterol increased nonsignificantly after 6 months and returned to baseline thereafter (p = .886). The mean estradiol level was suppressed from 44 pmol/l before treatment to &lt;18 pmol/l after 6 months (p = .014). No difference was found in the estradiol suppression rate whether baseline levels were &gt;40 or &lt;40 pmol/l.

Conclusion.
Letrozole has a safe effect on the lipid and TGL profiles of postmenopausal women with MBC. Estradiol levels were maximally suppressed within 6 months of treatment. The increased levels of TC during treatment were reversible and returned to normal levels after 3 months.
Nonmyeloablative Allogeneic Stem Cell Transplantation for Nasopharyngeal Carcinoma
Authors: Chia Whay K. , Wang Who W. , Lim Wan T. , Tai Wai M. , Sun Li , Thng Choon H. , Soe Yatanar , Yap Swee P. , Tan Eng H. , Toh Han C. 
Published: October 2010

Abstract
We present a case of a patient with metastatic nasopharyngeal carcinoma who failed two lines of palliative combination chemotherapy and was treated with allogeneic nonmyeloablative stem cell transplantation (NST). This patient achieved a durable tumor response, dramatic relief of his symptoms, and elimination of tumor in his bone marrow—an effect likely achieved via a graft-versus-tumor response. Although NST has been explored previously in solid tumors, such as renal cell carcinoma and breast cancer, it has not been widely explored in nasopharyngeal carcinoma. We also present data from a flow cytometric immune analysis and cytokine enzyme-linked immunosorbent assay analysis in the pre- and post-NST period.
Improved Clinical Decision Making Using the Evidence‐Based Approach
Authors: Newman Michael G. 
Published: October 2010

AbstractClinical experience, technical ability, and intuition are indispensable but no longer sufficient as the sole skills necessary to provide the best outcomes from periodontal and implant treatment. This article describes the evidence‐based approach, a comprehensive and rigorous literature evaluation process applied by scientists and clinicians. The methodology was used by the participants in The American Academy of Periodontology World Workshop to assess the evidentiary status of periodontal and implant treatment. The major goal of using the evidence‐based approach was to improve treatment decisions by increasing the strength of the inference that practitioners can derive from the base of knowledge contained within the literature.
Regulatory Issues Unique to Clinical Trials on Periodontal Diagnostic Methods and Devices
Authors: Gutman Steven I. , Tylenda Carolyn A. 
Published: October 2010

AbstractA wide variety of in vitro diagnostic products have been proposed for use in patients with periodontal disease. The Food and Drug Administration (FDA) review focuses on three important issues. First, the product must exhibit acceptable analytical performance (accuracy, precision, analytical sensitivity, and analytical specificity). Second, the effectiveness of the device must be clearly defined. The studies required to establish this will depend largely on the proposed intended use of the product. At a minimum, clinical or diagnostic sensitivity and specificity should be established. Finally, the product must meet the labeling requirements for in vitro devices. These requirements outlined in CFR 809.10(b) are comprehensive and cover 15 key elements including information about the principles of the analytical method; handling of instruments, reagents, and patient samples; test limitations; and test performance. Applicants developing products for any in vitro diagnostic device are encouraged to review the labeling regulations along with other divisional and office guidance material to help in defining the submission requirements. The FDA is willing to meet and work with companies prior to and during preclinical and clinical trials to assist in the development of appropriate study protocols. Ann Periodontol 1997;2:108‐112.
An Overview of Food and Drug Administration Regulation of Drugs, Biologies, and Devices to Be Used for Management of Periodontal Diseases
Authors: Tylenda Carolyn A. , Weintraub Michael 
Published: October 2010

AbstractThe Food and Drug Administration (FDA) has been actively involved in assuring the safety and effectiveness of medical products since 1906. The FDA was granted increased authority to regulate drugs in 1938 and devices in 1976. The regulatory requirements for marketing in the United States vary according to the type of product and the degree of risk associated with it. One route to the market is through the premarket notification [510(k)] process in which devices are evaluated according to their substantial equivalence to devices marketed prior to May 28, 1976. Many devices specifically intended to treat periodontal conditions have progressed through the 510(k) process based on their substantial equivalence to predicate devices. In some cases manufacturers have needed to provide clinical data in the form of Investigational Device Exemptions (IDE) to support an equivalence determination. Certain devices with indications for use in periodontal evaluation or therapy, specifically, those determined by FDA to be not substantially equivalent to legally marketed devices, require Premarket Approval Applications (PMA). For new drug products, clinical trials are carried out under an approved Investigational New Drug Application (IND). Application for approval for marketing is requested through a New Drug Application. Data from clinical trials conducted outside the United States may be considered by the FDA in support of the safety and effectiveness of the product. The FDA is continually developing and updating guidance documents and guidelines to assist manufacturers in gaining clearance/ approval to market new products. Ann Periodontol 1997;2:11–17.