bluuebunny/crossref_metadata_2025_split huggingface dataset:
Near-infrared spectroscopy in resin transfer molding—determination of the degree of cure
Authors: Salzmann Moritz , Märzinger Wolfgang , Teuchtmann Michael , Ravindran Bharath , Kirschnick Ulrike , Fauster Ewald 
Published: May 2024

AbstractNear-infrared (NIR) spectroscopy is employed to directly monitor the degree of cure of composite material during the curing phase in the resin transfer molding (RTM) process. The composite material consists of natural fibers and an epoxy-amine resin system. The quantitative determination of the degree of cure, α, from the NIR spectra is realized by partial least square (PLS) regression in conjunction with various pre-treatments of the spectral data. As a reference, the degree of cure is determined by isothermal differential scanning calorimetry (DSC) experiments. The best PLS model that could be obtained for α is characterized by a determination coefficient of prediction (R²P) of 0.980 and root mean square error of prediction (RMSEP) of 4.4 %. While the spectra change during curing according to the literature for each RTM trial, significant differences can be observed between the spectra of different RTM trials. The reasons for this are discussed in detail. The findings show the potential of inline NIR spectroscopy for monitoring α in the RTM process.
Remote ischemic preconditioning versus sham-control for prevention of anastomotic leakage after resection for rectal cancer (RIPAL trial): a pilot randomized controlled, triple-blinded monocenter trial
Authors: Hardt Julia , Seyfried Steffen , Brodrecht Hannah , Khalil Leila , Büttner Sylvia , Herrle Florian , Reissfelder Christoph , Rahbari Nuh N. 
Published: May 2024

Abstract
Purpose
Remote ischemic preconditioning (RIPC) reportedly reduces ischemia‒reperfusion injury (IRI) in various organ systems. In addition to tension and technical factors, ischemia is a common cause of anastomotic leakage (AL) after rectal resection. The aim of this pilot study was to investigate the potentially protective effect of RIPC on anastomotic healing and to determine the effect size to facilitate the development of a subsequent confirmatory trial.

Materials and methods
Fifty-four patients with rectal cancer (RC) who underwent anterior resection were enrolled in this prospectively registered (DRKS0001894) pilot randomized controlled triple-blinded monocenter trial at the Department of Surgery, University Medicine Mannheim, Mannheim, Germany, between 10/12/2019 and 19/06/2022. The primary endpoint was AL within 30 days after surgery. The secondary endpoints were perioperative morbidity and mortality, reintervention, hospital stay, readmission and biomarkers of ischemia‒reperfusion injury (vascular endothelial growth factor, VEGF) and cell death (high mobility group box 1 protein, HMGB1). RIPC was induced through three 10-min cycles of alternating ischemia and reperfusion to the upper extremity.

Results
Of the 207 patients assessed, 153 were excluded, leaving 54 patients to be randomized to the RIPC or the sham-RIPC arm (27 each per arm). The mean age was 61 years, and the majority of patients were male (37:17 (68.5:31.5%)). Most of the patients underwent surgery after neoadjuvant therapy (29/54 (53.7%)) for adenocarcinoma (52/54 (96.3%)). The primary endpoint, AL, occurred almost equally frequently in both arms (RIPC arm: 4/25 (16%), sham arm: 4/26 (15.4%), p = 1.000). The secondary outcomes were comparable except for a greater rate of reintervention in the sham arm (9 (6–12) vs. 3 (1–5), p = 0.034). The median duration of endoscopic vacuum therapy was shorter in the RIPC arm (10.5 (10–11) vs. 38 (24–39) days, p = 0.083), although the difference was not statistically significant.

Conclusion
A clinically relevant protective effect of RIPC on anastomotic healing after rectal resection cannot be assumed on the basis of these data.
Incidence and management of secondary deformities after megaendoprosthetic proximal femur replacement in skeletally immature bone sarcoma patients
Authors: Guder Wiebke K. , Engel Nina M. , Streitbürger Arne , Polan Christina , Dudda Marcel , Podleska Lars E. , Nottrott Markus , Hardes Jendrik 
Published: May 2024

Abstract
Introduction
Megaendoprosthetic reconstruction of bone defects in skeletally immature patients has led to the development of unique complications and secondary deformities not observed in adult patient cohorts. With an increasing number of megaendoprosthetic replacements performed, orthopedic oncologists still gain experience in the incidence and type of secondary deformities caused. In this study, we report the incidence, probable cause and management outcome of two secondary deformities after megaendoprosthetic reconstruction of the proximal femur: hip dysplasia and genu valgum.

Materials and methods
Retrospective analysis of 14 patients who underwent primary and/or repeat reconstruction/surgery with a megaendoprosthetic proximal femur replacement between 2018 and 2022.

Results
Mean patient age was 9.1 years (range 4–17 years). Stress shielding was observed in 71.4%. Hip dislocation was the most frequent complication (50%). While four dislocations occurred without an underlying deformity, secondary hip dysplasia was identified in 58.3% (n = 7/12) of intraarticular resections and reconstructions, leading to dislocation in 71.4% (n = 5/7). A genu valgum deformity was observed in 41.6% (n = 5/12). The incidence of secondary hip dysplasia and concomitant genu valgum was 42.9% (n = 3/7). Triple pelvic osteotomy led to rebound hip dysplasia in two cases (patients aged < 10 years), whereas acetabular socket replacement led to stable hip joints over the course of follow-up. Temporary hemiepiphyseodesis was applied to address secondary genu valgum.

Conclusions
Patients aged < 10 years were prone to develop secondary hip dysplasia and genu valgum following proximal femur replacement in this study. Management of secondary deformities should depend on remaining skeletal growth. Stress shielding was observed in almost all skeletally immature patients.
Retrospective evaluation of radiological and clinical outcomes after surgical treatment of proximal femoral fractures utilizing PFNA and PFNA augmented
Authors: Schneider Friedemann , Oettle Cedric , Runer Armin , Wagner Moritz , Arora Rohit , Lindtner Richard A. 
Published: May 2024

Abstract
Introduction
The primary aim of this study was to evaluate the clinical and radiological outcomes after surgical treatment of proximal femoral fractures utilizing the Proximal Femoral Nail Antirotation (PFNA), with the main focus on complications and reoperations. The secondary aim was to compare the outcomes of patients with and without cement augmentation of the cephalomedullary nails.

Materials and methods
All patients with an acute proximal femoral fracture consequently treated with a PFNA between January 2011 and Dezember 2018 were evaluated. Clinical and radiological data were assessed for intra- and postoperative complications, including treatment failure. In addition, intra- and postoperative radiographs were used to determine the position of the implant, and any migration, via Tip-Apex-Distance (TAD) and the caput-collum-diaphyseal angle (CCD). The accuracy of the fracture reduction was rated according to Baumgaertners criteria.

Results
Two hundred sixty-four consecutive patients (mean age 78.8 ± 12.0; 73.1% female) were included. The predominant OTA/AO fracture classification was 31A1 (153 cases, 58.0%). The average duration of surgery was 63.1 ± 28.0 min and showed no significant differences between PFNA and PFNA with augmentation. The implant positioning was rated as good in 222 cases (84.1%). Two hundred sixty-three patients (99.6%) showed evidence of healing within the time frame of three months postoperatively, one case of delayed union healed after secondary dynamization. During the observational period, 18 patients (6.8%) required a total of 23 additional surgeries. Overall, a lower reoperation rate was observed following the use of the augmentation option (2/86 patients (2.3%) vs. 16/178 patients (9.0%), p = 0.04). In particular, there were no cases of cut-out or cut-through among patients who underwent augmentation as part of osteosynthesis.

Conclusions
Overall reoperation rate after surgical treatment of proximal femoral fractures utilizing the Proximal Femoral Nail Antirotation (PFNA) was 6.8%, with 23 additional surgeries performed in 18 patients. The usage of the PFNA with augmentation showed equally good implant positioning, excellent healing rates and fewer postoperative complications compared to the PFNA implant alone with a similar overall duration of surgery.
Functional results after hiatal repair and gastropexy without fundoplication in patients with paraoesophageal hernia
Authors: Bomio-Pacciorini Laura , Gaspar-Figueiredo Sérgio , Mantziari Styliani , Godat Sébastien , Schäfer Markus , Teixeira Farinha Hugo 
Published: May 2024

Abstract
Purpose
Paraoesophageal hernias (PEH) are associated with a high complication rate and often occur in elderly and fragile patients. Surgical gastropexy without fundoplication is an accepted alternative procedure; however, outcomes and functional results are rarely described. Our study aims to evaluate short-term outcomes and the long-term quality of life after gastropexy as treatment for PEH.

Methods
Single center cohort analysis of all consecutive patients who underwent gastropexy for PEH without fundoplication. Postoperative outcomes and functional results were retrospectively collected. Reflux symptoms developed postoperatively were reported using the validated quality of life questionnaire: GERD-Health Related Quality of Life Qestionnaire (GERD-HRQL).

Results
Thirty patients (median age: 72 years (65–80)) were included, 40% classified as ASA III. Main PEH symptoms were reflux (63%), abdominal/thoracic pain (47%), pyrosis (33%), anorexia (30%), and food blockage (26%). Twenty-six laparoscopies were performed (86%). Major complications (III-IVb) occurred in 9 patients (30%). Seven patients (23%) had PEH recurrence, all re-operated, performing a new gastropexy. Median follow-up was 38 (17–50) months. Twenty-two patients (75%) reported symptoms resolution with median GERD-HRQL scale of 4 (1–6). 72% (n = 21) reported operation satisfaction. GERD-HRQL was comparable between patients who were re-operated for recurrence and others: 5 (2–19) versus 3 (0–6), p = 0.100.

Conclusion
Gastropexy without fundoplication was performed by laparoscopy in most cases with acceptable complications rates. Two-thirds of patients reported symptoms resolution, and long-term quality-of-live associated to reflux symptoms is good. Although the rate of PEH recurrence requiring a new re-intervention remained increased (23%), it does not seem to affect long-term functional results.
Prognostic value of perioperative changes in the prognostic nutritional index in patients with surgically resected non-small cell lung cancer
Authors: Hayasaka Kazuki , Notsuda Hirotsugu , Onodera Ken , Watanabe Tatsuaki , Watanabe Yui , Suzuki Takaya , Hirama Takashi , Oishi Hisashi , Niikawa Hiromichi , Okada Yoshinori 
Published: May 2024

Abstract
Purpose
This single-institution retrospective cohort study was conducted to assess the prognostic significance of perioperative changes in the prognostic nutritional index (PNI) in patients who underwent surgery for non-small cell lung cancer (NSCLC).

Methods
Clinicopathological data were collected from 441 patients who underwent lobectomy for NSCLC between 2010 and 2016.The PNI ratio (postoperative PNI/preoperative PNI) was used as an indicator of perioperative PNI changes. Prognostic differences were investigated based on PNI ratios.

Results
The optimal cut-off value of the PNI ratio for overall survival (OS) was set at 0.88 using a receiver operating characteristic curve. The PNI ratio was inversely related to a high smoking index, interstitial lung disease, and postoperative pulmonary complications. The 5-year OS rates for the high vs. low PNI ratio groups were 88.2% vs. 68.5%, respectively (hazard ratio [HR]: 3.04, 95% confidence interval [CI]: 1.90–4.86). Multivariable analysis revealed that a low PNI ratio was significantly associated with poor prognosis (HR: 2.94, 95% CI: 1.77–4.87). The PNI ratio was a more sensitive indicator than postoperative PNI status alone for identifying patients at high risk of mortality, particularly those with non-lung cancer causes.

Conclusion
The perioperative PNI change is a significant prognostic factor for patients with NSCLC.
Serum neurofilament light chain levels correlate with small fiber related parameters in patients with hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN)
Authors: Galosi Eleonora , Costanzo Rocco , Forcina Francesca , Morino Stefania , Antonini Giovanni , Salvetti Marco , Lauletta Antonio , Luigetti Marco , Romano Angela , Primiano Guido , Guglielmino Valeria , Fionda Laura , Garibaldi Matteo , Esposito Nicoletta , Falco Pietro , di Pietro Giuseppe , Truini Andrea , Leonardi Luca 
Published: May 2024

Abstract
Background
Recent evidence suggests that both serum neurofilament light chain (sNfL) levels and small fiber related diagnostic variables may be valuable disease biomarkers of hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN).
Our study aimed to explore the relations between sNfL and small fiber related skin biopsy and quantitative sensory testing (QST) parameters in a cohort of ATTRv-PN patients and pre-symptomatic carriers.

Methods
We retrospectively analyzed data from 13 ATTRv patients and 21 pre-symptomatic carriers who underwent sNfL dosage, skin biopsy, and QST, and analyzed correlations between sNFL, intraepidermal nerve fiber density (IENFD), and cold (CDT) and warm detection thresholds (WDT).

Results
Both sNfL and small fiber related parameters significantly differed between carriers and patients (sNfL: p < 0.0001; IENFD: p = 0.0008; CDT, WDT: < 0.0001). sNFL levels were normal in all carriers, altered in 85% of patients, negatively correlated with distal IENFD (r = -0.47, p = 0.005), and significantly correlated with CDT (r = -0.68; p < 0.0001) and WDT (r = 0.57; p < 0.0001).

Conclusions
Our study showed that sNfL reliably discriminates symptomatic ATTRv-PN patients from pre-symptomatic carriers, and found significant relations between sNfL, skin biopsy, and QST small fiber related parameters, suggesting that sNfL might be a valuable biomarker of peripheral nerve involvement in ATTRv-PN and a supportive criterion for symptomatic disease transition.
Probing the carbon neutrality drive of environmental-related technologies and energy transition in France and Germany: a novel time–frequency technique
Authors: Adebayo Tomiwa Sunday , Alola Andrew Adewale , Ullah Sami 
Published: May 2024

AbstractThis study presents a rare comparative analysis of the factors influencing environmental quality through greenhouse gas (GHG) emissions in the European Union member states’ largest economies, i.e., France and Germany. By considering the unique economic, energy, and environmental characteristics of both countries, the finding unveils a novel perspective in the literature. The research utilizes a recently developed wavelet local multiple correlation (WLMC) technique with quarterly dataset spanning from 1990/Q1 to 2020/Q4. The results demonstrate that environmental-related information and communication technologies innovations, energy transition, and financial development play significant roles in limiting the growth of GHGs emission, particularly in the medium and long term. The wavelet-based Granger causality analysis reveals evidence of feedback causality among the variables in both countries in the medium and long term. Moreover, there are slight differences in the short-term relationships given that the observations are generally similar in later period. Overall, the findings offer a deeper understanding and policy insights regarding the time and frequency dynamics of GHG drivers in France and Germany.
Graphical abstract
Optimization of municipal solid waste collection system: systematic review with bibliometric literature analysis
Authors: Neto Alice B. P. Santos , Simões Carla L. , Simoes Ricardo 
Published: May 2024

AbstractMunicipal solid waste management (MSWM) requires significant planning and objective definitions of each of its stages. Waste collection and transportation stages are of utmost importance, and they represent a significant cost of the process. In this context, a systematic study using bibliometric analysis was conducted, seeking to identify and understand the applied methodologies and tools, as well as which parameters and approaches are employed to optimize the solid urban waste collection system. The analysis portfolio features 12 publications, focusing on the optimization of municipal solid waste (MSW) collection systems, mostly with the aim of optimizing routes for transporting waste from the collection points to the final destination, with the goal of reducing the costs of this stage. Results highlight how these studies only consider as optimization criteria the reduction of the travelled distance and lack other dimensions (such as an environmental impact perspective). Some of the studies demonstrate the vital role of technology in optimizing the waste collection operation, from the use of geographic information systems (GIS) to using sensors or smart bins. Future research efforts should widen the scope of what is considered in optimizing the waste collection system.
The impact of different perspectives on the cost-effectiveness of remote patient monitoring for patients with heart failure in different European countries
Authors: Mokri Hamraz , van Baal Pieter , Rutten-van Mölken Maureen 
Published: May 2024

Abstract

Background and objective
Heart failure (HF) is a complex clinical syndrome with high mortality and hospitalization rates. Non-invasive remote patient monitoring (RPM) interventions have the potential to prevent disease worsening. However, the long-term cost-effectiveness of RPM remains unclear. This study aimed to assess the cost-effectiveness of RPM in the Netherlands (NL), the United Kingdom (UK), and Germany (DE) highlighting the differences between cost-effectiveness from a societal and healthcare perspective.

Methods
We developed a Markov model with a lifetime horizon to assess the cost-effectiveness of RPM compared with usual care. We included HF-related hospitalization and non-hospitalization costs, intervention costs, other medical costs, informal care costs, and costs of non-medical consumption. A probabilistic sensitivity analysis and scenario analyses were performed.

Results
RPM led to reductions in HF-related hospitalization costs, but total lifetime costs were higher in all three countries compared to usual care. The estimated incremental cost-effectiveness ratios (ICERs), from a societal perspective, were €27,921, €32,263, and €35,258 in NL, UK, and DE respectively. The lower ICER in the Netherlands was mainly explained by lower costs of non-medical consumption and HF-related costs outside of the hospital. ICERs, from a healthcare perspective, were €12,977, €11,432, and €11,546 in NL, the UK, and DE, respectively. The ICER was most sensitive to the effectiveness of RPM and utility values.

Conclusions
This study demonstrates that RPM for HF can be cost-effective from both healthcare and societal perspective. Including costs of living longer, such as informal care and non-medical consumption during life years gained, increased the ICER.
Dietary supplementation and health behavior in a sample of young adults in Austria
Authors: Dorczok Marie Celine , Schrank Beate , Mittmann Gloria , Steiner-Hofbauer Verena 
Published: May 2024

Abstract
Aim
The market for dietary supplements (DS) is booming since DS can be a simple and targeted dietary component if a wholesome nutrition is not available. DS consumption might be linked to other health behaviors that help people to maintain health and reduce potential health risks. The aim of this study was to identify and compare selected health behaviors among young Austrian DS consumers.

Subjects and methods
An online questionnaire (including dietary habits, consumption of DS, physical activity, general state of health, DEGS FFQ) was handed out via a pannel distribution to young Austrian adults aged 18 to 30 years.

Results
The questionnaire was answered by 400 participants, of which 33% consumed DS regularly. There were no significant differences between the sexes with regard to the consumption of DS. Most participants (66%) consumed DS without medical prescription. Only the consumption of healthy food as well as weekly time spent on sports as part of health behavior was able to predict DS consumption.

Conclusion
Although DS consumers show significantly higher levels of health behavior in some facets, they do not differ from non-DS consumers in a large number of health-relevant aspects. Our results indicate that DS consumers exhibit a broader spectrum of health-relevant behaviors than non-DS consumers and thus contribute to maintaining their health. Further studies with larger national samples and alternative assessment methods are necessary to consolidate the existing results and hypotheses.
Perspectives of environmental health officers on climate change adaptation in Australia: a cross-sectional survey
Authors: Walter Tony G. , Bricknell Lisa K. , Preston Robyn G. , Crawford Elise G. C. 
Published: May 2024

Abstract
Aim
Climate change adaptation is critical for reducing and preventing many community health risks. The Environmental Health Profession has decades of experience of effective interventions for reducing and preventing many community health risks. However, in Australia adaptation is not included in the profession’s scope of practice leaving the community health at risk to climate change. The aim of this study was to assess the perspectives of Australian Environmental Health Officers concerning climate change health adaptation and whether this should be included in their role.

Subject and methods
Eighty-nine (89) eligible participants undertook a mixed method survey between November 2021 and January 2022. These participants were members of Environmental Health Australia and held a relevant degree in environmental health. The questions on the survey were related to six themed items: (1) climate change and health, (2) climate change adaptation, (3) the profession’s role in capacity building for adaptation, (4) hurdles for building adaptive capacity, (5) health awareness as a bridging concept and finally, (6) disaster risk reduction.

Results
The findings from this study indicate that the majority of participants were concerned for their community health from climate change impacts. A system thinking approach is required to effectively address and understand complex health risks. There was also an overwhelming support for the profession to integrate approaches of disaster risk reduction and climate change adaptation in health. However, the environmental health profession is facing some significant hurdles to building adaptive capacity to climate change.

Conclusion
This study demonstrates the environmental health profession does want to have a role in climate change adaptation in Australia. These findings, with further qualitative research, could bolster the preventive public health approach in building community health resilience to climate change and related disasters.