bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ellagic acid: a potential inhibitor of enhancer of zeste homolog-2 and protein arginine methyltransferase-5
Authors: Nalla Kirankumar , Chatterjee Biji , Poyya Jagadeesha , Swain Aishwarya , Ghosh Krishna , Pan Archana , Joshi Chandrashekhar G , Manavathi Bramanandam , Kanade Santosh R 
Published: May 2024

AbstractDysregulation of epigenetic processes, characterized by aberrant DNA methylation patterns and histone modifications, is a hallmark of cancer, driving its initiation, progression, and metastasis by silencing tumor suppressor genes or activating oncogenes. Perturbations in histone modifications such as H3K27me3 by EZH2 and H4R3me2s by PRMT5 play significant roles in these epigenetic alterations, disrupting normal gene expression and facilitating oncogene activation while suppressing tumor suppressor genes. Consequently, inhibitors targeting enzymes involved in DNA methylation, histone modification, or chromatin remodeling, such as PRMTs and PRC complexes, are promising anti-cancer agents, with several undergoing pre-clinical and clinical trials. Our screening of a phytochemical library revealed ellagic acid as an effective inhibitor of both EZH2 and PRMT5. Ellagic acid interacts strongly with the EZH2 and PRMT5:MEP50 complex, binding to their active sites through π-cation interactions and hydrogen bonds. Surface Plasmon Resonance study confirmed potent binding affinities of ellagic acid, with KD values of 3.28E-06 and 6.54E-05 for EZH2 and PRMT5:MEP50 respectively.In-vitroassays validated inhibitory effects on EZH2 and PRMT5:MEP50 by reducing the levels of their catalytic products H3K27me3 and H4R3me2s respectively and induction of autophagy and apoptosis. FurtherIn-vivostudies using mouse xenografts further demonstrated significant tumor size reductions upon oral administration of ellagic acid, with decreased expression of the proliferative marker ki67 and histone repressive marks. Taken together we showed that inhibition of EZH2 and PRMT5:MEP50 by ellagic acid could be used to develop breast cancer therapeutic drug.
Targeting PRMT3 Impairs Methylation and Oligomerization of HSP60 to Boost Anti-Tumor Immunity by Activating cGAS/STING Signaling
Authors: Shi Yunxing , Wu Zongfeng , Liu Shaoru , Zuo Dinglan , Niu Yi , Qiu Yuxiong , Qiao Liang , He Wei , Qiu Jiliang , Yuan Yunfei , Wang Guocan , Li Binkui 
Published: May 2024

AbstractHepatocellular carcinoma (HCC) is a highly lethal cancer for which current available treatment options have limited efficacy. Immunotherapy has emerged as a promising therapeutic option for HCC, yet resistance to immunotherapy is a major challenge. Here, we uncover protein arginine methyltransferase 3 (PRMT3) as a novel driver of immunotherapy resistance in HCC. We show that PRMT3 expression is induced by activated T cells in response to immune checkpoint blockade (ICB) via an interferon-gamma (IFNγ)−STAT1 signaling pathway, and that high PRMT3 expression inversely correlates with tumor-infiltrating CD8+T cells and predicts poor response to ICB in HCC patients. We demonstrate that genetic depletion and pharmacological inhibition of PRMT3 induce a profound influx of T cells into tumors and activate anti-tumor immunity to suppress HCC progression. Mechanistically, we demonstrate that PRMT3 methylates HSP60, a mitochondrial chaperone protein, at R446, and that this novel post-translational modification is required for HSP60 oligomerization and maintaining mitochondrial homeostasis. We reveal that targeting PRMT3-dependent HSP60-R446 methylation boosts anti-tumor immunity by disrupting mitochondrial function, increasing mitochondrial DNA (mtDNA) leakage, and activating the cGAS/STING pathway, a key innate immune sensor of cytosolic DNA. Importantly, we provide genetic and pharmacologic evidence that targeting PRMT3 enhances anti-PD1 efficacy and anti-tumor immunity in HCC mouse models. Our study identifies PRMT3 as a potential biomarker and therapeutic target to overcome immunotherapy resistance in HCC.
Cluster structure of
3α+p
states in
N13
Authors: Bishop J. , Rogachev G. V. , Ahn S. , Barbui M. , Cha S. M. , Harris E. , Hunt C. , Kim C. H. , Kim D. , Kim S. H. , Koshchiy E. , Luo Z. , Park C. , Parker C. E. , Pollacco E. C. , Roeder B. T. , Roosa M. , Saastamoinen A. , Scriven D. P. 
Published: May 2024

Cluster states in N13 are extremely difficult to measure due to the unavailability of B9+α elastic-scattering data.
Using β-delayed charged-particle spectroscopy of O13, clustered states in N13 can be populated and measured in the 3α+p decay channel.
One-at-a-time implantation and decay of O13 was performed with the Texas Active Target Time Projection Chamber. 149β3αp decay events were observed and the excitation function in N13 reconstructed.
Four previously unknown α-decaying excited states were observed in N13 at an excitation energy of 11.3, 12.4, 13.1, and 13.7 MeV decaying via the 3α+p channel.
These states are seen to have a [9B(g.s)⨂α/p+C12(02+)], [9B(12+)⨂α], [9B(52+)⨂α], and [9B(52+)⨂α] structure, respectively. A previously seen state at 11.8 MeV was also determined to have a [p+C12(g.s.)/p+C12(02+)] structure. The overall magnitude of the clustering is not able to be extracted, however, due to the lack of a total width measurement. Clustered states in N13 (with unknown magnitude) seem to persist from the addition of a proton to the highly α-clustered C12. Evidence of the 12+ state in B9 was also seen to be populated by decays from N★13.Published by the American Physical Society2024
Decays of
1−+
charmoniumlike hybrid using lattice QCD
Authors: Shi Chunjiang , Chen Ying , Gong Ming , Jiang Xiangyu , Liu Zhaofeng , Sun Wei 
Published: May 2024

By extracting the transition amplitudes, we give the first lattice QCD prediction of the two-body decay partial widths of the 1−+ charmoniumlike hybrid ηc1. Given the calculated mass value mηc1=4.329(36)  GeV, the ηc1 decay is dominated by the open charm modes D1D¯, D*D,¯ and D*D¯* with partial widths of 258(133), 88(18), and 150(118) MeV, respectively. The coupling of ηc1 to χc1 plus a flavor singlet pseudoscalar is not small, but χc1η decay is suppressed by the small η−η′ mixing angle. The partial width of ηc1→ηcη′ is estimated to be around 1 MeV. We suggest experiments to search for ηc1 in the P-wave D*D¯ and D*D¯* systems. Especially, the polarization of D*D¯* can be used to distinguish the 1−+ product (total spin S=1) from 1−− products (S=0).

Published by the American Physical Society
2024
Ultrahigh frequency primordial gravitational waves beyond the kHz: The case of cosmic strings
Authors: Servant Géraldine , Simakachorn Peera 
Published: May 2024

We investigate gravitational-wave backgrounds (GWBs) of primordial origin that would manifest only at ultrahigh frequencies, from kilohertz to 100 gigahertz, and leave no signal at LIGO, the Einstein Telescope, the Cosmic Explorer, LISA, or pulsar-timing arrays. We focus on GWBs produced by cosmic strings and make predictions for the GW spectra scanning over high-energy scale (beyond 1010  GeV) particle physics parameters. Signals from local string networks can easily be as large as the big bang nucleosynthesis/cosmic microwave background bounds, with a characteristic strain as high as 10−26 in the 10 kHz band, offering prospects to probe grand unification physics in the 1014–1017  GeV energy range. In comparison, GWB from axionic strings is suppressed (with maximal characteristic strain ∼10−31) due to the early matter era induced by the associated heavy axions. We estimate the needed reach of hypothetical futuristic GW detectors to probe such GWB and, therefore, the corresponding high-energy physics processes. Beyond the information of the symmetry-breaking scale, the high-frequency spectrum encodes the microscopic structure of the strings through the position of the UV cutoffs associated with cusps and kinks, as well as potential information about friction forces on the string. The IR slope, on the other hand, reflects the physics responsible for the decay of the string network. We discuss possible strategies for reconstructing the scalar potential, particularly the scalar self-coupling, from the measurement of the UV cutoff of the GW spectrum.

Published by the American Physical Society
2024
How does strategic deviation affect firm performance? The roles of financing constraints and institutional investors
Authors: Zhang Shujun , Fu Jialiang , Zhu Weiwei , Zhao Guoxiong , Xu Shuwei , Chang Biqing 
Published: May 2024

PurposeThis study investigates the economic outcomes of the strategic deviation (SD), the fundamental and crucial question in institutional theory and strategic management. Previous studies have yielded contradictory findings. This study reconciles conflicting results by distinguishing the effects of the SD on financial and market performance, examining the mechanism of financing constraints and the boundary condition of institutional investor heterogeneity.Design/methodology/approachThis research collected data from Chinese A-shares listed manufacturing firms from 2009 to 2021 from the CSMAR and Wind databases. This study conducted empirical tests using OLS models with Stata 15.FindingsEmpirical results demonstrate that the SD has different impacts on different dimensions of performance. The SD negatively impacts financial performance while positively impacts market performance. Financing constraints mediate the main effects. Moreover, transactional institutional investors positively moderate the negative effect of the SD on financial performance, whereas stable institutional investors negatively moderate the positive effect of the SD on market performance.Originality/valueBy systematically revealing how the SD has different effects on financial and market performance, this study reconciles the debate on the SD between institutional theorists and strategy scholars. This research makes contributions to the research stream by providing reasonable explanations for conflicting conclusions. Furthermore, by introducing the overlooked perspective of financing constraints, this research identifies crucial mediating mechanisms and highlights the double-edged effect of financing constraints, enriching our understanding of financing constraints. Finally, this study investigates the moderating effects of institutional investor heterogeneity, thereby making valuable contributions to the comprehension of boundary conditions.
The impact of digital transformation on firms’ value: examining the role of ESG performance and the effect of information interaction
Authors: Wang Disheng , Xia Xiaohong 
Published: May 2024

PurposeThis study aims to examine the impact of digital transformation on firms’ value and explore the mediating impact of ESG performance and moderating impact of information interaction.Design/methodology/approachData was collected from companies listed on the Shanghai and Shenzhen stock exchange between 2012 and 2020 with 21,488 observational samples, featuring a selection of 3,348 companies. Panel data regression techniques were used to test the mediating role of ESG performance and the moderating role of information interaction.FindingsThe study found that digital transformation can improve firms’ ESG performance, which in turn positively affects their value. The firms that engage in more interaction with outsiders benefit more from digital transformation and have a higher value.Originality/valueThis study provides new theoretical insight into improving firms’ value through digital transformation and ESG performance. It is the first to discuss and study the moderating role of information interaction in the relationship between digital transformation and firms’ value.
Stochastic approach for maximum power point determination for bifacial PV modules by implementing two different cell models
Authors: Najdoska Angela , Cvetkovski Goga Vladimir 
Published: May 2024

Purpose
This paper presents the determination of the maximum power point of a bifacial photovoltaic (PV) system using two different cell models. The optimal power point is determined by using genetic algorithm (GA), as an optimisation tool. The purpose of this paper is to find which of the two analysed models gives better results in the determination of the maximum power point of a bifacial PV system for different solar irradiations. The quality of the results gained from both models is analysed based on the value of the objective function.

Design/methodology/approach
In this research work, the maximum power point of bifacial PV modules is determined by using two different PV cell models, such as the simplified and two-diode models of PV cells. Based on the input electrical data for the analysed bifacial PV module as well as the mathematical model of the two PV cell presentations, the values for the current and the voltage at the maximum power point for a given solar irradiation and working temperature are determined by the algorithm for each solution in the population and generation.

Findings
From the presented results and the performed analysis, it can be concluded that GA is quite appropriate for this purpose and gives adequate results for both models and for all working conditions. The two-diode model was found to be more suitable compared with the simplified model due to its complexity. Therefore, although the power difference for each of the scenarios for the two compared models does not differ significantly among the two models, it is in favour of the two-diode model. Which implicates that the for fast and simple calculation the simplified model can also do the job.

Practical implications
This approach can be very successfully applied in the design process of a PV plant to forecast the output characteristics of the PV system if there is enough information about the weather conditions for a given location. This procedure can be very helpful in the process of selection of right PV module and inverter for a given location.

Originality/value
An optimisation technique using GA as an optimisation tool has been developed and successfully applied in the determination of the maximum power point for a bifacial PV module using to different models of solar cell. The results are compared with the analytically determined values as well as with the values given from the producer and they show good agreement.
Effects of sensory cues on consumers’ wine taste perceptions and behavior: evidence from a wine-tasting experiment
Authors: Yuan Weixi , Guo Fumei , Li Mimi , Song Haiyan 
Published: May 2024

Purpose
This study aims to investigate how sensory cue order, wine knowledge and visual–olfactory (V–O) congruence affect consumer’s taste perceptions of wine and their subsequent behavior.

Design/methodology/approach
An experiment was performed to identify the effects of sensory cue congruence and sensory cue order on wine consumers’ perceptions of wine, affective evaluations, cognitive evaluations and purchase intentions.

Findings
Wine experts exhibited positive emotional responses to congruent sensory cues in the V–O order. Experts’ enjoyment of wine’s aroma, their emotional responses, their cognitive evaluations and their purchase intentions were lower in the incongruent condition. Consumers’ negative emotions elicited by the V–O sequence were also less intense than those triggered by the olfactory–visual (O–V) sequence. Wine experts demonstrated more positive emotional responses in the V–O sensory congruent condition.

Research limitations/implications
This study highlights how visual and olfactory sensory cue order, wine knowledge and sensory cue congruence interact to clarify wine-related behavioral intention. Findings reveal the roles of these factors in shaping sensory perceptions, cognitive evaluations, affective evaluations and behavior related to wine consumption.

Practical implications
This study holds implications for various stakeholders, including winemakers, wine businesses, restaurants and the broader hospitality industry. Wine businesses can enhance advertising effectiveness by tailoring their marketing efforts to customers’ knowledge levels and emphasizing the inherent attributes that align with individuals’ preferences. Winemakers can improve consumers’ sensory experiences by enhancing the natural color of wines. Restaurants can strive to ignite diners’ positive emotions and experiences by providing congruent information. Furthermore, sensory-driven strategies can be used in the hospitality sector to elevate customers’ positive emotions.

Originality/value
This study fills gaps in wine research by delineating how wine knowledge and related sensory cues can influence consumers’ sensory perceptions, cognitive evaluations, affective evaluations and behavior. These aspects have been largely overlooked in previous work.
Sustainability concerns on pro-sustainable travel behavior: combining the United Nations SDGs, norm activation model and value theory
Authors: Assaker Guy 
Published: May 2024

PurposeThis study examines the effect of sustainable development goal (SDG) concerns regarding the sustainability issues raised in the United Nations SDG agenda on pro-sustainable travel behavior (PSTB) by building on the norm activation model as well as value theory (altruism), with the latter assumed to moderate the effect of SDG concerns on PSTB.Design/methodology/approachThe model was tested using structural equation modeling (SEM) based on data from 200 USA respondents who have traveled internationally in the past 12 months.FindingsThe results confirmed the effect of SDG concerns on positively influencing PSTB both directly and indirectly (through the NAM variables of “responsibility” and “obligation”). Additionally, results revealed that altruism positively moderates the effect of SDG concerns on PSTB.Practical implicationsResults provide tourism businesses and destinations with a better understanding of which aspects of the 17 issues identified in the UN SDG agenda are more likely to influence travelers’ future PSTB and whether such behavioral changes additionally depend on people’s individual altruism levels.Originality/valueUnlike previous studies focusing mainly on environmental concerns and tourists’ pro-environmental behavior, this study offers a more comprehensive understanding of PSTB in light of today’s UN SDGs.
The effect of political connections on the relationship between managers’ personality traits and corporate social responsibility disclosure
Authors: Salehi Mahdi , Bashirimanesh Nazanin 
Published: May 2024

Purpose
Corporate social responsibility (CSR) might be among the primary factors ensuring any organization’s survival, and disclosing its related information is very important. This research initially investigates the effect of managers’ behavior characteristics, including overconfidence, myopia and narcissism and corporate political ties on the disclosure of CSR. This study also aims to assess the mediating impact of political connections on the association between managerial personality traits and CSR.

Design/methodology/approach
The research sample included 129 listed companies on the Tehran Stock Exchange from 2013 to 2020. Behavioral managerers charecteristics. A multivariate regression method with combined data (firm-year) was used to test the research hypotheses.

Findings
The results show that overconfidence and managerial myopia cause the disclosure of CSR to decrease. Managers’ overconfidence and short-term attitudes lead to a decrease in the level of CSR activities of the companies and their disclosure, respectively, 0.021 and 0.025. However, the existence of narcissism in managers and having political ties by companies may lead to an increase in the disclosure of the CSR, respectively, around 0.089 and 0.02. Further findings also indicate that political connections may motivate narcissistic managers to increase CSR disclosure near 0.037. However, the results document no significant impact of political ties on the relationship between managerial overconfidence and myopia with CSR involvement.

Research limitations/implications
According to the findings, the authors recommend to stockholders that employing narcissistic managers and improving political connections might be two effective strategies to enhance the level of CSR engagement. One of the critical limitations of the current paper might be its generalizability. As Iran is an emerging and fossil fuel seller country, its institutional settings may significantly differ from those of developed and industrial nations. Thus, the readers of these nations must consider such an important issue.

Originality/value
For the first time, to the best of the authors’ knowledge, this research has investigated the moderating effect of political ties on the association between management behavioral characteristics and the level of fulfilling CSR by listed companies.
Developing university students’ personal skills: the role of business–university partnership programmes
Authors: Aljuwaiber Abobakr 
Published: May 2024

Purpose
This study aims to explore the influence of Mutqen programmes on university students’ personality and skills development. It evaluates the cognitive attitudes of university student participants in Mutqen training programmes. The research was analysed thematically, and this paper reports on the roles businesses and universities play in enhancing students’ personality and skills and the importance of knowledge acquisition to develop students’ career prospects.

Design/methodology/approach
Using a quantitative research approach, the study used a descriptive survey design. A total of 1,039 respondents based in Saudi Arabia participated voluntarily in the survey.

Findings
The results revealed a positive impact from Mutqen programmes on students’ personality and skills development. Moreover, the outcomes demonstrated that the Mutqen programmes promote knowledge acquisition, which enhances future career readiness by enabling students to positively develop their awareness of potential future career requirements.

Originality/value
The critical contribution of this paper is that it empirically evaluates the perceived impact of social corporate training programmes on students’ personality and skills development from the perspective of the students themselves.