bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automated Insulin Delivery in Women With Pregnancy Complicated by Type 1 Diabetes
Authors: Lee Tara T.M. , Collett Corinne , Bergford Simon , Hartnell Sara , Scott Eleanor M. , Lindsay Robert S. , Hunt Katharine F. , McCance David R. , Barnard-Kelly Katharine , Rankin David , Lawton Julia , Reynolds Rebecca M. , Flanagan Emma , Hammond Matthew , Shepstone Lee , Wilinska Malgorzata E. , Sibayan Judy , Kollman Craig , Beck Roy , Hovorka Roman , Murphy Helen R. ,   for the AiDAPT Collaborative Group
Published: April 2024

(Abstracted from N Engl J Med 2023;389:1566–1578
Hyperglycemia during pregnancy is an important risk factor for complications, such as preterm birth, large birth weight, and admission to the intensive care unit. Those at highest risk already have glycated hemoglobin above target levels at the start of pregnancy.
Early Metformin in Gestational Diabetes
Authors: Dunne Fidelma , Newman Christine , Alvarez-Iglesias Alberto , Ferguson John , Smyth Andrew , Browne Marie , O’Shea Paula , Devane Declan , Gillespie Paddy , Bogdanet Delia , Kgosidialwa Oratile , Egan Aoife , Finn Yvonne , Gaffney Geraldine , Khattak Aftab , O’Keeffe Derek , Liew Aaron , O’Donnell Martin 
Published: April 2024

(Abstracted from JAMA 2023;330(16):1547–1556
Worldwide, about 2.93 million pregnancies are complicated by gestational diabetes mellitus (GDM) annually. GDM is associated with an increased risk of maternal adverse outcomes, such as weight gain, cesarean delivery (CD), and preeclampsia, as well as fetal adverse outcomes, such as admission to the neonatal intensive care unit (NICU) due to birth injuries and respiratory disease.
An Overview of Reproductive Carrier Screening Panels for Autosomal Recessive and/or X-Linked Conditions: How Much Do We Know?
Authors: Wang Tianjiao , Scuffham Paul , Byrnes Joshua , Delatycki Martin B. , Downes Martin 
Published: April 2024

(Abstracted from Prenatal Diagnosis 2023;43:1416–1424
Reproductive carrier screening is designed to identify couples who are at a high risk of passing genetic disorders to their children. Advances in genetic screening technology have recently allowed for the commercial development and availability of genetic tests that can screen for autosomal recessive and X-linked genes for many disorders simultaneously.
Advancements in the application of uterine ultrasound elastography
Authors: Barrett Francesca , Willson Stephanie , Werner Marie 
Published: April 2024

Purpose of review
This article reviews recent advances in ultrasound elastography in diagnosing and evaluating the normal nongravid uterus and the infertile uterus in the gynecologic patient.

Recent findings
Focusing on the most recent primary literature, studies have demonstrated new findings among a breadth of gynecologic clinical settings. Studies in the nongravid uterus have found that menopausal status, age, and menstrual phase have not been associated with changes in uterine tissue stiffness. Focusing on myometrial disease, there have been conflicting data regarding the ability to distinguish uterine fibroids from adenomyosis. One area of expanding research surrounding uterine elastography includes the infertile population, where ongoing studies attempt to provide a predictive model using shear wave elastography (SWE) in patients undergoing in-vitro fertilization.

Summary
Ultrasound elastography has become an increasingly studied and utilized tool in assessing physiologic and pathologic processes in the field of gynecology. Evaluating tissue stiffness through strain and SWE can serve to improve diagnosis of various uterine and cervical lesions, as well as prognosticate outcomes after fertility treatments. This growing area of research will continue to establish the role and application of ultrasound elastography into clinical practice.
Clinical Presentations of Bupropion Prescription Drug Misuse
Authors: Noe Greg , Shah Kaushal , Ongchuan Samantha , Munjal Sahil 
Published: April 2024

Abstract

Background
Among prescribers, bupropion is considered a substance of low misuse potential, with some studies showing lesser misuse potential than caffeine. However, several case reports exist of recreational bupropion misuse and diversion. Our goal is to understand at-risk populations, clinical courses, interventions, and outcomes after acute ingestion of bupropion via oral, intravenous route, and insufflation.

Methods
The systematic review was registered with PROSPERO on August 5, 2023. We conducted a systematic literature search on July 30, 2023, utilizing 8 databases with the help of the Medical Subject Headings (MeSH) term “Bupropion” in the context of misuse and abuse. Ultimately, we found 17 articles with qualitative synthesis relevant to our study objective and meeting our inclusion/exclusion criteria.

Results
Bupropion insufflation and intravenous injection occur almost exclusively in patients with a substance use disorder history, with a preponderance of patients with stimulant use disorder or multiple substance use disorders. Additionally, many were dual-diagnosis patients with a history of attention deficit hyperactivity disorder and stimulant use disorder, treated with bupropion. Patients describe the effects of bupropion insufflation/IV injection as a milder “cocaine-like” high that is brief, with less severe withdrawal effects of anxiety and agitation. The most common side effect at presentation was tachycardia, followed by seizures responsive to IV benzodiazepines. IV injection seems particularly insulting to the vascular system, with cellulitis, tissue necrosis, and digital ischemia as documented adverse effects.

Conclusions
This systematic review highlights the bupropion misuse potential in certain patient populations and serves to increase awareness among clinicians. Additional patient screening, monitoring and follow-up, surveillance, and further research are needed to investigate and prevent bupropion misuse in at-risk patient populations entirely.
Patient Preferences for Disposable and Reusable Vaginal Specula and Their Willingness to Compromise in the Era of Climate Change: A Cross-Sectional Study
Authors: Ten Buuren Amber A.A. , Poolman Tessa B. , Bullens Lauren M. , Van Hanegem Nehalennia , Bongers Marlies Y. , Klerkx Wenche M. , Timmermans Anne , Zuithoff Nicolaas P.A. , Kwee Anneke 
Published: April 2024

(Abstracted from BJOG. 2024;131:684–689
The World Health Organization emphasizes that the climate crisis is the single biggest health threat facing humanity, and more than 200 medical journals have called on world leaders to take more and faster action against climate change. Despite this, hospitals have increasingly relied on disposable instruments such as plastic specula, which are incinerated after a single use.
Screening for Critical Congenital Heart Defects in Sweden
Authors: Lannering Katarina , Kazamia Kalliopi , Bergman Gunnar , Östman-Smith Ingegerd , Liuba Petru , Dahlqvist Jenny Alenius , Elfvin Anders , Mellander Mats 
Published: April 2024

(Abstracted from Pediatrics 2023;152:e2023061949
Critical congenital heart defects (CCHDs) affect between 1 and 3 of every 1000 live-born infants and require intervention in the short term after birth. Early identification of affected infants contributes to significantly to better outcomes in both the short- and long-term.
Three-Tiered Fetal Heart Rate Interpretation System and Adverse Neonatal and Maternal Outcomes: A Systematic Review and Meta-analysis
Authors: Zullo Fabrizio , Di Mascio Daniele , Raghuraman Nandini , Wagner Steve , Brunelli Roberto , Giancotti Antonella , Mendez-Figueroa Hector , Cahill Alison G. , Gupta Megha , Berghella Vincenzo , Blackwell Sean C. , Chauhan Suneet P. 
Published: April 2024

(Abstracted from Am J Obstet Gynecol 2023;229(4):377–387
Electronic fetal monitoring is used on more than 3.8 million parturients a year. Despite its ubiquitous use, fetal heart rate tracing (FHRT) is marred by intraobserver variability and inconsistent use of terms to describe contraction patterns.
Dual-Energy Computed Tomography Virtual Noncalcium Imaging of Intracranial Arteries in Acute Ischemic Stroke: Differentiation Between Acute Thrombus and Calcification
Authors: Shinohara Yuki , Ohmura Tomomi , Sasaki Fumiaki , Sato Yuichiro , Inomata Takato , Itoh Toshihide , Kinoshita Toshibumi 
Published: April 2024

Objective
Hyperdense artery sign (HAS) on noncontrast brain computed tomography (CT) indicates an acute thrombus within the cerebral artery. It is a valuable imaging biomarker for diagnosing large-vessel occlusion; however, its identification may be challenging with the presence of vascular calcification. Dual-energy CT virtual noncalcium (VNCa) imaging using a 3-material decomposition algorithm is helpful for differentiating between calcification and hemorrhage. This study aimed to clarify the potential of VNCa imaging for differentiating HAS from vascular calcification.

Methods
Patients with acute ischemic stroke and large-vessel occlusion identified on MR angiography, who also underwent noncontrast dual-energy CT, were included. The 80 kV/Sn 140 kV mixed images, with a weighting factor of 0.4, were considered 120 kVp-equivalent images. Postprocessing using a 3-material decomposition algorithm to differentiate between calcium (Ca), cerebrospinal fluid, and hemorrhage was performed via a commercially available 3-dimensional workstation. A mixed image, VNCa image, color-coded Ca image, and color-coded Ca image with VNCa image overlay (color-coded Ca-overlay image) were obtained, and axial reconstruction with a 1-mm slice thickness was performed for each image type. Two experienced neuroradiologists conducted imaging evaluations in consensus.

Results
Thirty-four patients (mean age, 76.0 years; 21 male and 13 female patients) were included. The mixed and VNCa images revealed an HAS (indicating an acute clot) corresponding to the large-vessel occlusion site in 30 patients. Among them, the VNCa and color-coded Ca-overlay images enabled clear differentiation between the acute thrombus and adjacent vessel wall calcification in 5 patients. Among the other 4 patients, the VNCa, Ca-overlay, and Ca images identified calcified cerebral emboli in the M1 segment in 1 patient. For the other 3 patients, no high attenuation corresponding to magnetic resonance angiography findings was observed in any of the mixed, VNCa, Ca-overlay, or Ca images.

Conclusions
VNCa and color-coded Ca-overlay images obtained via dual-energy brain CT enabled differentiation of acute thrombus from vessel wall calcification and calcified cerebral emboli in patients with acute ischemic stroke.
Time-resolved function of cell polarity kinases PRKCZ and PRKCI in CNS myelination
Authors: Mercau Maria E. , Hackbarth Rieke-Marie , Liu Xinran , Wang Haowei , Zhang Le , Basu Malay K. , Rothlin Carla V. , Ghosh Sourav 
Published: April 2024

ABSTRACTThe atypical Protein Kinase C (aPKC) is a critical component of the PAR polarity complex, as well as of cell polarity in general. There are two paralogs of aPKC in the mammalian genome. Their expression pattern and functional role in oligodendrocyte lineage differentiation and development remains heretofore uncharacterized. Here we show that both paralogs of aPKC – PRKCI, the primary transcript ofPrkciand PKMz, an alternate transcript ofPrkcz– are expressed during oligodendrocyte differentiation, yet are functionally non-redundant. Asymmetric cell division and early specification of the oligodendrocyte fate stage required both paralogs. By contrast, the stage of oligodendrocyte maturation involving membrane polarization and myelination of axons continued to require PKMz, but no longer needed PRKCI. Taken together, our results indicate to a two-stage role of aPKCs and cell polarity in oligodendrocyte differentiation and development.
Design of a self-regulating mRNA gene circuit
Authors: Dykeman Eric C. 
Published: April 2024

ABSTRACTProtein expression from mRNAin vivois predominately controlled via regulatory feedback mechanisms that adjust the level of mRNA transcription. However, for positive sense single-stranded RNA viruses, protein expression is often controlled via secondary structural elements, such as internal ribosomal entry sites, that are encoded within the mRNA. The self-regulation of mRNA translation observed in this class of viruses suggests that it may be possible to design mRNAs that self-regulate their protein expression, enabling the creation of mRNAs for vaccines and other synthetic biology applications where protein levels in the cell can be tightly controlled without feedback to a transcriptional mechanism. As a proof of concept, I design a polycistronic mRNA based on bacteriophage MS2, where the upstream gene is capable of repressing synthesis of the downstream gene. Using a computational tool that simulates ribosome kinetics and the co-translational folding of the mRNA in response, I show that mutations to the mRNA can be identified which enhance the efficiency of the translation and the repression of the downstream gene. The results of this study open up the possibility of designing bespoke mRNA gene circuits in which the amount of protein synthesised in cells are self-regulated for therapeutic or antigenic purposes.
Developing urban infrastructure constructions for increasing e-commerce sales: the moderating roles of aging population
Authors: Shou Minghuan , Jia Furong , Yu Jie 
Published: April 2024

PurposeThe aging population, a higher proportion of older adults (aged 65+), is considered a global and severe problem, while the information systems (IS) literature on detecting the relationship between the aging population and the development of electronic commerce (e-commerce) is limited and insufficient. Hence, the main objective of this paper is to examine whether an aging population can moderate the effect of infrastructure constructions on e-commerce sales and whether an aging population can affect e-commerce sales.Design/methodology/approachTo investigate the relationship between the aging population and e-commerce sales, this study proposes two potential influential mechanisms: moderating the effects of infrastructure development on e-commerce sales and direct influence. Subsequently, a sample of 31 Chinese provinces from 2013 to 2019 is utilized to conduct regression analyses in order to examine these hypotheses.FindingsThe findings suggest that the development of urban transportation infrastructure and network constructions can significantly contribute to the enhancement of e-commerce sales, and the influence cannot be affected by aging population. Furthermore, it is noteworthy that an aging population can have a positive effect on e-commerce sales.Practical implicationsThe findings can inform future infrastructure constructions by assessing the potential of infrastructure projects to boost e-commerce sales and examining whether this effect varies in an aging population context.Originality/valueThe findings substantiate the pivotal role of older adults in the e-commerce industry. Moreover, the obtained results establish a positive relationship between an aging population and e-commerce sales, thereby offering diverse perspectives on existing theories.
Bank ownership and credit risk: an empirical study of Indonesian Islamic local banks
Authors: Sudarsono Heri , Sholihin Mahfud , Susamto Akhmad Akbar 
Published: April 2024

Purpose
This study aims to determine the effect of bank ownership on the credit risk of Indonesian Islamic local banks (ILBs).

Design/methodology/approach
This study uses the system generalized method of moments (GMM) estimation technique with a sample of 155 Islamic local banks in Indonesia from 2012 to 2019.

Findings
The results show that commissioner board (D.COW) ownership has a negative effect on credit risk. This indicates that an increase in the number of shares of Islamic local banks owned by the commissioner board reduces credit risk. On the other hand, government ownership (D.GOW), the Sharia supervisory board (D.SOW) and the director board (D.DOW) do not affect credit risk.

Practical implications
The government, Sharia supervisory board and director board need opportunities to easily own more Islamic local bank shares. Therefore, the provisions regarding the share ownership rights of the government, Sharia supervisory board and director board need to be improved to increase their role in reducing credit risk.

Originality/value
Previous researchers have not studied the effect of government ownership, the commissioner board, the Sharia supervisory board and the ownership of directors on credit risk at the ILB in Indonesia.
Exploring customer engagement tensions when pursuing responsible business practices
Authors: Gallan Andrew S. , Hildebrand Diogo , Komarova Yuliya , Rubin Dan , Shay Ronen 
Published: April 2024

PurposeDesigning and developing responsible business practices can create various tensions for service organizations. The purpose of this research is to develop a deeper understanding of the relationship between customer engagement (CE) and responsible business practices (e.g. environmental, social and/or governance [ESG], corporate social responsibility [CSR] and diversity, equity, and inclusion [DEI]) and explore customer engagement tensions that service organizations may face.Design/methodology/approachThis research develops a list of CE-related responsible business practice tensions and empirically explores their relevance through in-depth interviews with nine ESG professionals.FindingsThis paper makes three important contributions. First, we find support for nine distinct but related tensions with implications for CE that organizations must navigate when pursuing responsible business practices. Second, interview participants provide some suggestions for tackling these tensions, which we support with relevant theories. Finally, we develop a conceptual framework that may stimulate future service research and inform the implementation of ESG strategies.Originality/valueTo the best of the authors’ knowledge, this research is the first to conceptualize and empirically explore the tensions that emerge between responsible business practices and CE. The authors develop a novel analysis of the CE-related tensions that emerge when pursuing an ESG strategy.Research limitations/implicationsThe findings are based on a small sample of ESG professionals. Future research may take a quantitative approach to further evaluate the role that these tensions play in engaging customers.Practical implicationsThis research provides a conceptual framework that may guide ESG professionals in understanding, framing and navigating CE-related tensions when pursuing responsible business practices.Social implicationsA social benefit may be found when service organizations are better able to successfully navigate CE-related tensions when pursuing responsible business practices.
Slow drawdown, fast recovery: Stream macroinvertebrate communities improve quickly after large dam decommissioning
Authors: Atristain Miren , Solagaistua Libe , Larrañaga Aitor , von Schiller Daniel , Elosegi Arturo 
Published: April 2024

Abstract

Dam removal is increasingly considered as a river restoration tool for impoundments that harm the environment or have exceeded their lifespan. However, few studies report the ecological consequences of large dam removal.

We performed a multiple before‐after/control‐impact (mBACI) study to investigate the consequences of the decommissioning of a large dam (42 m high) on instream habitat and invertebrate communities in a temperate, forested catchment of northern Spain.

Before decommissioning, lack of fine sediments and high concentrations of manganese and iron occurred below the dam but decreased downstream. Invertebrate taxa richness and diversity were reduced, and pollution‐sensitive taxa were missing just below the dam.

The drawdown of the reservoir, the first step towards its decommissioning, mobilized stored sediments causing frequent turbidity peaks downstream, which nevertheless, caused no detrimental effects on macroinvertebrate communities. One year after drawdown, the communities downstream from the dam, as well as those in the newly formed stream in the area formerly impounded by the reservoir, became very similar to those in control reaches, showing a successful restoration project.

Synthesis and applications. Dam decommissioning helps restore instream habitats and facilitates the recovery of invertebrate communities in a very short time frame if there are nearby sources of potential colonizers. Slow drawdown reduces the transport of the sediments accumulated in the reservoir and their potential downstream impacts, even more if prior to drawdown the reservoir is kept full for years to promote the deposition of sediments in marginal areas that will later be readily colonized by trees.
Pesticide risk during commercial apple pollination is greater for honeybees than other managed and wild bees
Authors: Mueller Tobias G. , Baert Nicolas , Muñiz Paige A. , Sossa David E. , Danforth Bryan N. , McArt Scott H. 
Published: April 2024

Abstract

Most pesticide research has focussed on risk to managed honeybees, but other managed and wild bees are also exposed to pesticides. Critically, we know little about the magnitude and sources of risk to honeybees compared with other bees during crop pollination.

To compare pesticide exposure and risk across wild and managed bees, we sampled the main bee groups present during bloom in 20 apple orchards, including managed honeybees (Apis mellifera), managed bumblebee workers (Bombus impatiens), wild mining bees (Andrena spp. and Andrena [Melandrena] spp.), bumblebee foundress queens (Bombus impatiens) and eastern carpenter bees (Xylocopa virginica). We screened all bees for 92 pesticides and computed a Risk Quotient using available toxicity data (honeybee LD50s), adjusting for differences in toxicity known to scale with body mass. To gain insight into exposure origin, we compared residues in bees to those in focal orchard apple and dandelion flowers.

Nearly all bee samples contained pesticides (95%), with the average contamination level ranging from 7.1 ± 2.8 parts per billion (ppb) in B. impatiens workers to 388.4 ± 146.2 ppb in Andrena. Exposure profiles were similar for all bees except A. mellifera, whose unique exposure profile included high levels of the neonicotinoid insecticide thiamethoxam.

All bee groups except wild B. impatiens queens had at least one sample exceeding a US Environmental Protection Agency or European Food Safety Authority exposure level of concern. Apis mellifera experienced significantly greater risk than other bee groups, with 63% and 81% of samples exceeding an acute or chronic exposure level of concern, respectively. Risk to honeybees was driven primarily by high thiamethoxam levels not found in focal orchard flowers and likely originating outside the orchard.

Synthesis and applications: We find that pesticide exposure and risk differ between honeybees and other managed and wild bees during apple pollination. Furthermore, pesticide exposure is a landscape‐scale phenomenon and therefore measures to reduce exposure must consider the surroundings beyond focal farms. Limiting orchard sprays, while reducing on‐farm exposures, will not protect far‐foraging bees from off‐farm exposures such as thiamethoxam, which we hypothesize is coming from nearby seed‐treated corn fields planted during apple bloom.