bluuebunny/crossref_metadata_2025_split huggingface dataset:
956-P: Successful Use of U-500 Insulin with the Tandem X2 Pump with Control IQ (CIQ)
Authors: AKCAN TUGCE , BASINA MARINA 
Published: June 2024

Objectives: The American Diabetes Association recommends the use of U-500 insulin for individuals with insulin dose requirements over 200 units per day. Commercially available insulin pumps are FDA-approved for U-100 insulin. Patients requiring high daily insulin doses must frequently refill pump reservoirs due to the use of large insulin volumes. U-500 allows for less frequent reservoir refills and a reduction in insulin infusion site discomfort. Previously, the VIVID study demonstrated the safety and efficacy of U-500 insulin with pump therapy used in manual mode. We describe a case of using U-500 insulin in a Tandem X2 insulin pump with the CIQ algorithm.
Methods: We reviewed clinical and insulin pump data for a patient before and after switching to U-500 Lispro insulin in a Tandem pump with the CIQ algorithm. The starting insulin dose was calculated as 20% of the U-100 insulin Total Daily Dose (TDD), with 50% allocated to basal insulin delivery. The carbohydrate ratio and correction factor were adjusted proportionally.
Results: Prior to switching to U-500 insulin, the patient's average TDD of insulin was 254.25 units, with a Time in Range (TIR) of 20%. A month following the transition, there was a marked improvement in TIR to 53% with a TDD of 40.53 units of U-500 insulin, without increasing the rate of hypoglycemia. Time spent in the CIQ algorithm averaged 94% per day. The mean blood glucose levels decreased from 250 mg/dL to 185 mg/dL. Additionally, the use of U-500 insulin extended the infusion set wear time from one day to three days.
Conclusion: This is the first-ever reported case highlighting the successful use of the CIQ algorithm with U-500 insulin in a Tandem X2 pump for a patient with a high insulin dose demand. Through appropriate dose conversions and pump setting adjustments, there was a marked improvement in glycemic control in a safe and effective manner. It provides a viable option for patients with severe insulin resistance to use automated insulin delivery systems.

Disclosure
T. Akcan: None. M. Basina: None.
Penambahan Biji Chia (Salvia hispanica L.) pada Fermentasi Tempe Kedelai dalam Peningkatan Aktivitas Antioksidan dan Nilai Kesukaan
Authors: Dwianto Stefanus Agung , Meitiniarti V Irene , Sukmana Andreas Binar Aji , Dewi Lusiawati 
Published: June 2024

Tempe merupakan produk pangan berbahan kedelai (Glycine max) yang difermentasi dengan melibatkan mikroba dari genus Rhizopus. Tempe memiliki berbagai kandungan gizi dan senyawa, salah satunya adalah antioksidan. Untuk meningkatkan kandungan antioksidan dalam tempe dapat dilakukan dengan penambahan bahan alami. Biji chia (Salvia hispanica) dipilih karena termasuk bahan pangan fungsional dan memiliki kandungan antioksidan. Tujuan penelitian ini untuk mengetahui efektivitas penambahan biji chia pada fermentasi tempe kedelai dalam peningkatan antioksidan dan nilai kesukaan. Penelitian dilakukan menggunakan RAL dengan satu faktor dan empat taraf perlakuan, yaitu konsentrasi penambahan biji chia 0%, 0,5%, 1% dan 1,5% (b/b). Penentuan aktivitas antioksidan dilakukan dengan metode DPPH, sedangkan uji hedonik dilakukan menggunakan kuesioner pada 15 orang panelis. Hasil pengukuran antioksidan menunjukkan penambahan biji chia pada tempe dapat meningkatkan aktivitas antioksidan yang dapat dilihat pada persen inhibisi. Persen inhibisi paling tinggi yaitu pada konsentrasi biji chia 1% yaitu sebesar 69,83%. Pada uji hedonik dengan uji Univariate dan uji lanjutan Duncan, perlakuan tempe tanpa pemberian bumbu menunjukkan tidak berbeda nyata antar konsentrasi perlakuan pada parameter aroma dan tekstur. Sedangkan perlakuan tempe dengan penambahan bumbu menunjukkan tidak berbeda nyata antar konsentrasi perlakuan pada parameter tekstur dan rasa.
Modification of Starch with Amylosucrase: Methods, Physicochemical Properties and Health Implications
Authors: Dewi Angela Myrra Puspita , Tethool Eduard Fransisco 
Published: June 2024

Amylosucrase is a transglucosylase enzyme that utilizes sucrose as a substrate to produce α-1,4 glucan (amylose-like polymer). Modification of starch with Amylosucrase can increase the degree of polymerization, degree of crystallinity, heat stability, and increase the proportion of slow digestible starch (SDS) and resistant starch (RS). Thus, Amylosucrase (ASase) modified starch has enormous potential to be developed in the food industry because the consumption of ASase modified starch can improve insulin sensitivity and reduce blood glucose response, making it suitable for consumption by people with Diabetes Mellitus. In addition, consumption of ASase-modified starch also has the potential to prevent obesity and improve blood lipid profile.
Conhecimento dos pacientes do SUS sobre o gerenciamento de resíduos gerados em suas residências.
Authors: Marchi Virginia , Bacaro Mirta Rodrigues Coelho , Kovac Valéria , Ramos José Francisco , Duarte Ana Raquel Leal , Pinheiro Marcos , Sá Nelson Leite , Paixão Susana , Ferreira Ana , Silva Odair Ramos , Habermann Mateus , Junqueira Virginia Berlanga Campos , Azzalis Ligia Ajaime , Fonseca Fernando Luiz Affonso 
Published: June 2024

A gestão dos resíduos sólidos é um dos maiores desafios enfrentados pelo poder público. O conhecimento e conscientização da população quanto ao uso racional e descarte adequado dos resíduos torna-se um aspecto importante neste processo. Pretendeu-se verificar o conhecimento prévio dos pacientes do SUS sobre a separação e destinação adequada dos resíduos sólidos gerados em suas residências e propor medidas de conscientização. 100 pacientes do Ambulatório de Especialidades da Faculdade de Medicina do ABC foram entrevistados aleatoriamente enquanto aguardavam atendimento. Foram obtidas informações socioeconômicas, sobre gestão de resíduos residenciais etc. A diferença das respostas entre os grupos socioeconômicos foi analisada por teste de ?2 (?=5%). O hábito de separar resíduos é mais frequente em pessoas de renda e escolaridade elevada (p=0,024), assim como o entendimento da sigla 3R (reduzir, reutilizar e reciclar) (p<0,001) e o grau de satisfação dos gestão de resíduos (p=0,009). Os resultados indicam maior conhecimento e engajamento nas práticas corretas de destinação dos resíduos sólidos entre pacientes de melhor nível socioeconico. Sugere-se que o período de espera por atendimento médico seja utilizado para divulgação e orientação acerca do assunto.
Alterações no solo ocasionadas pela fertirrigação dos dejetos suínos
Authors: Krajeski Arildo , Povaluk Maristela 
Published: June 2024

A suinocultura brasileira está em franco crescimento no país; dados afirmam que os estados de Santa Catarina, Rio Grande do Sul, Paraná e Minas Gerais têm os maiores rebanhos, sendo que os dejetos dos animais são inerentes à atividade, o produtor tem responsabilidade com relação a sua destinação. Neste contexto, a pesquisa efetuada ofereceu a condição da correta utilização dos dejetos suínos em prol do aumento da produtividade nas lavouras e da prevenção do meio ambiente, pois é considerada uma atividade de grande potencial poluidor podendo alterar as condições do solo da região. Esta pesquisa teve por finalidade constatar quais as principais mudanças do solo ocasionadas com a fertilização através de dejetos suínos, tendo como base a empresa Master Genética Animal Ltda, unidade VII. Foram disponibilizados aproximadamente trinta e dois hectares, onde retirou-se do local cinco amostras de solo para análise físico-química e doze amostras de solo para análise de microscopia; obtendo resultados reais para a pesquisa realizada na região do planalto norte catarinense. A coleta de solo auxiliou no diagnóstico na quantificação dos microrganismos que fazem parte deste micro biosistema, sua função demonstra a atenção e o cuidado com o meio ambiente, pois interagem diretamente com a cultura utilizada na área de lavoura. Buscando a visão de diferentes instituições para a utilização deste material como adubo orgânico. Com o correto manejo deste substrato incorporado no solo, obtêm-se a valoração nutricional do mesmo, podendo ser utilizado em culturas como gramíneas, reduzindo assim a compra de adubos químicos e melhorado a porosidade do solo. Em contrapartida, há necessidade do devido controle e monitoramento ambiental na adubação que este solo deve receber, pois o seu mau manejo poderá acarretar em danos ao meio ambiente.
Feeding dogs a high-fat diet induces metabolic changes similar to natural aging, including dyslipidemia, hyperinsulinemia, and peripheral insulin resistance
Authors: McKenzie Brennen , Peloquin Matthew , Tovar Ashley , Graves Jessica L , Ratcliff Ellen , Tucker Katya , Vo Kenny , Greenwood Karen , Halioua-Haubold Celine-Lea , Juarez-Salinas Dina 
Published: June 2024

Abstract

OBJECTIVE
The goal of this study was to characterize changes induced by a high-fat diet in body composition, insulin levels and sensitivity, blood lipids, and other key biomarkers also associated with the metabolic dysfunction that occurs with natural aging.

ANIMALS
24 male Beagle dogs, 3 to 7 years of age, of mixed castration status.

METHODS
Dogs were randomly assigned to continue twice daily feeding of the commercial adult maintenance diet (n = 12, including 2 intact) that they were previously fed or to a high-fat diet (12, including 2 intact) for 17 weeks between December 1, 2021, and April 28, 2022. Assessments included body composition (weight, body condition score, and adipose mass determined by deuterium enrichment), clinical chemistries, plasma fatty acid quantification, oral glucose tolerance test, and histology of subcutaneous and visceral adipose biopsy samples.

RESULTS
The high-fat diet led to increased body weight, body condition score, fat mass and adipocyte size, hyperinsulinemia and peripheral insulin resistance, and elevations in serum lipids, including cholesterol, triglycerides, and several species of free fatty acids. Leptin levels increased in dogs fed a high-fat diet but not in control dogs. There were no significant changes in routine clinical chemistry values in either group.

CLINICAL RELEVANCE
Feeding a high-fat diet for 17 weeks led to potentially deleterious changes in metabolism similar to those seen in natural aging in dogs, including hyperinsulinemia, insulin resistance, and dyslipidemia. A high-fat diet model may provide insights into the similar metabolic dysfunction that occurs during natural aging.
Deforestation as a catalyst for natural disaster and community suffering: A cycle in the socioecological system
Authors: Golar Golar , Muis Hasriani , Isrun Isrun , Simorangkir Wahyu Syahputra , Fadhliah Fadhliah , Ali Muhammad Nur , Basir-Cyio Muhammad 
Published: June 2024

Abstract
Lore Lindu National Park (LLNP) is a conservation area that contains a lot of wood resources. Various illegal community activities have become widespread, such as illegal mining and illegal logging. So, this research aims to determine the involvement of communities around forest areas in material and wood theft from June to October 2021. To determine forest encroachment, we find explanatory variables, using qualitative description integrated with perceptual tests and Classification and Regression Tree (CART) analysis. Based on the results of the 10-fold cross-validation analysis with the smallest Rcv (x-Val relative error) value of 0.428, with a classification accuracy of 68.6%, a four-node optimum tree was obtained, which explained that as many as 86 forest encroachers were victims of a vast landslide disaster along with flood and whirlwind, due to which there was no longer any property left for them. Their encroachment affected the condition of land cover. The data on the land cover change, from 2010 to 2020, showed a reduction of 15,369.20 ha or 6.90%, which indicated a severe threat to the sustainability of LLNP as a biodiversity conservation area that should be protected. The involvement in illegal logging by communities living around the forest areas resulted from the loss of their agricultural land for their livelihoods due to natural disasters such as flood, landslide and whirlwind that destroyed infrastructure and community settlement facilities. As a result, these losses and destruction were a catalyst for forest destruction. Initially being in the frontline for preserving the forest, however, the community has now turned into silent partners with licensed wood businesspeople. The community eventually becomes a subsystem in the social ecology system (SES), which negatively affects the destruction of forest resources, production and conservation forests.
Density optimisation of pine plantations in the Left-Bank Steppe in ukraine
Authors: Tkach Viktor , Tarnopilska Oksana , Luk’yanets Volodymyr , Musienko Sergiy , Kobets Oleksii , Rumiantsev Maksym , Bondarenko Vira 
Published: June 2024

Abstract
The paper presents the results of long-term research on different cultivation regimes for planted Scots pine (Pinus sylvestris L.) stands in the experiment initiated by B. Gavrylov in 1932 in the Left-Bank Steppe in Ukraine. The aim of the study is to identify the optimal density of planted pine stands that provides the largest growing stock at the age of 95 years. The study shows that it is possible to form highly productive pine stands by regulating their density within certain limits through their thinning. The results suggest that the intensity of thinning in young pine plantations in the Left-Bank Steppe conditions in Ukraine can vary within a wide range (30–70% of the growing stock). With the increase in the intensity of thinning of pine plantations, the growing stocks do not change significantly, but other stand characteristics, such as average height and average diameter, increase significantly. In young stands, high-intensity thinning creates favourable conditions for the growth of the remaining trees. As the intensity of thinning increases, the number of tending operations in the stand decreases and the operation costs are reduced. Accordingly, the number of interventions in the forest ecosystem decreases. The efficiency of wood mass use increases by decreasing losses from natural decline. The impact of machinery on the environment in such pine stands during harvesting is significantly reduced. Such stands are more resistant to man-caused load as well as to forest pests and diseases. The most rational was the cultivation regime, under which about 1,000 stems·ha−1 were left to the age of 30 for further growth after thinning. At the age of 95, such stands had the largest growing stock and basal area as well as the best health condition.
The effect of commercial thinning in Scots pine stands on the growth of black cherry
Authors: Korzeniewicz Robert , Rutkowski Bartłomiej , Kowalkowski Wojciech , Baranowska Marlena 
Published: June 2024

Abstract
Black cherry (Prunus serotina Ehrh.) is one of the most abundant invasive species found in Polish forests. The mass occurrence of this species in pine stands is one of the main problems of silviculture. Therefore, the paper addresses the problem of the effect of commercial thinning, which increases the access of light to the lower layers of the stand, on the annual growth of rings and the development of black cherry. The study attempted to determine the strength of the progression of the black cherry threat as expressed by increased diameter increment. It was assumed that the thickness increment of mature black cherry individuals after thinning would be significantly greater compared to the average thickness increment before thinning. Over time after the treatment, the average growth of sprouts of black cherry will decrease.
Six pine stands differing in age and timing of the silvicultural treatment in the Golub–Dobrzyn Forest District (N 57°81′42″ E 50°20′19″) were analysed. A positive effect of commercial thinning on the thickness increment of black cherry was found in all the studied plots. Over time, the average increment of black cherries resulting from the clearance decreased.
Conducting late thinning, in pine stands where black cherry occurs, results in an increased threat of its expansion. To limit the development of black cherry at this stage of pine stand management, two solutions are possible. The first is to abandon late thinning or reduce the intensity of the treatment, which will inhibit its rapid expansion. The second scenario is to limit the occurrence of black cherry a few years before thinning, perform thinning and introduce understorey or underplanting from native competitive tree species.
Creation of a Different Landscape for Cardiovascular Diseases and Diabetes in Europe Through JACARDI Joint Action
Authors: Zaletel Jelka , Farkaš Lainščak Jerneja 
Published: June 2024

Abstract
The Joint Action on CARdiovascular diseases and DIabetes (JACARDI) aims to reduce the burden of cardiovascular disease and diabetes in European countries, both at the individual and societal levels. The initiative covers the entire patient journey, from improving health literacy and awareness of cardiovascular diseases and diabetes, travelling through primary prevention among high-risk populations and screenings, reaching people living with cardiovascular diseases and diabetes, improving service pathways, self-management, and labour participation. The project involves 21 European countries, 76 partners and plans to implement 142 pilot interventions, ensuring diversity in terms of cultural backgrounds, public health priorities, and healthcare systems.
In Slovenia, interventions will be developed and tested to improve screening for diabetes through community involvement, the involvement of people with diabetes in education programmes in health centres, and the involvement of people with diabetes in a screening programme for diabetic retinopathy. A set of unified, comprehensive and integrated health education materials and approaches will be developed for both healthcare providers and patients referred to the outpatient cardiovascular rehabilitation programme. The effectiveness of the upgraded health education intervention will be tested in a randomized trial. Furthermore, Slovenian experts are involved in developing a harmonized implementation methodology across all 142 pilot interventions, including contextual analysis at the country and pilot levels, multidimensional assessment and evaluation.
JACARDI will enhance cross-national collaboration, maximizing the exploitation of lessons learned through a clear strategy, promoting the integration and sustainability of approaches to achieve high-level impact, including the implementation of effective interaction, cooperation and co-creation between science and policy.
Motivational Factors Influencing the Choice of Medical Studies and Future Career Plans among Montenegrin Students
Authors: Zvrko Elvir , Popović Nataša , Radunović Miodrag , Nikolić Goran 
Published: June 2024

Abstract

Introduction
There is a concerning trend of emigration among highly educated individuals in Montenegro. This includes medical professionals who seek better job opportunities abroad. The aim of the present study was to identify the primary motivational factors driving Montenegrin medical students to pursue a career in medicine, and whether these factors undergo changes over the course of their studies.

Methods
A cross-sectional study included 210 medical students in Montenegro, 27.62% were males, and 72.38% were females. The mean age of the students was 21.90 years (SD=3.05) (range 19–39). Their academic motivation was analysed using the Academic Motivation Scale, previously validated in various cultural contexts.

Results
The results showed that autonomous motivation levels were higher than controlled motivation levels (p<0.001) among students in Montenegro, which has been previously associated with better learning outcomes. Students with medical doctors among their family members had higher extrinsic motivation related to rewards and punishments (extrinsic motivation with external regulation p=0.018). Amotivation showed a trend of increasing as the students got closer to graduation (p=0.057). Only 8.1% of students planned a career in primary healthcare, and 1% wished to specialize in family medicine.

Conclusions
This study’s findings, which indicate high levels of autonomous motivation among medical students, are of significant importance. They contribute to a comprehensive understanding of the motivation factors among medical students and young healthcare professionals in Montenegro. Moreover, they provide a basis for the implementation of strategic interventions to retain highly skilled medical professionals within the country’s workforce, thereby addressing the concerning trend of emigration among this group.
The Prevalence of Self-Reported Systemic Allergic Reaction to Hymenoptera Venom in Beekeepers Worldwide: A Systematic Literature Review and Meta-Analysis
Authors: Carli Tanja , Locatelli Igor , Košnik Mitja , Kukec Andreja 
Published: June 2024

Abstract

Background
Beekeepers represent a high-allergic risk population group due to their unavoidable seasonal or persistent exposure to the elicitors of Hymenoptera venom allergy, bees in particular. A systematic literature review and meta-analysis aimed to estimate the prevalence of self-reported systemic allergic reaction to Hymenoptera venom among beekeepers worldwide.

Methods
We rigorously reviewed and conducted meta-analysis on observational studies retrieved from seven electronic databases (MEDLINE via PubMed, Web of Science Core Collection, Scopus, Academic Search Complete, ScienceDirect, Cumulative Index to Nursing and Allied Health Literature, Zoological Record), spanning data from inception to August 1, 2023. The Joanna Briggs Institute Prevalence Critical Appraisal Tool was employed to assess the risk of bias. A meta-analysis was conducted to synthesize evidence.

Results
Out of 468 studies, eight original articles met the inclusion criteria. The estimated overall lifetime and one-year prevalence of self-reported systemic allergic reaction to bee venom were 23.7% (95% CI: 7.7–53.4) and 7.3% (95% CI: 5.8–9.2), respectively. The estimated lifetime prevalence of self-reported systemic allergic reaction to bee venom for grades III–IV (severe systemic allergic reaction) was 6.0% (95% CI: 3.0–11.7). In general, substantial heterogeneity and a high risk of bias were observed across the majority of studies. The impact of geographical location and climate differences on the estimated lifetime prevalence is suggestive for severe systemic allergic reaction.

Conclusions
Future observational cross-sectional studies should employ rigorous study designs, using validated questionnaires, and thoroughly report the observed health outcomes, verified by physicians.