bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chest x‐ray has low sensitivity to detect silicosis in artificial stone benchtop industry workers
Authors: Hoy Ryan F. , Jones Catherine , Newbigin Katrina , Abramson Michael J. , Barnes Hayley , Dimitriadis Christina , Ellis Samantha , Glass Deborah C. , Gwini Stella M. , Hore‐Lacy Fiona , Jimenez‐Martin Javier , Pasricha Sundeep S. , Pirakalathanan Janu , Siemienowicz Miranda , Walker‐Bone Karen , Sim Malcolm R. 
Published: May 2024

AbstractBackground and ObjectiveChest x‐ray (CXR) remains a core component of health monitoring guidelines for workers at risk of exposure to crystalline silica. There has however been a lack of evidence regarding the sensitivity of CXR to detect silicosis in artificial stone benchtop industry workers.MethodsPaired CXR and high‐resolution computed tomography (HRCT) images were acquired from 110 artificial stone benchtop industry workers. Blinded to the clinical diagnosis, each CXR and HRCT was independently read by two thoracic radiologists from a panel of seven, in accordance with International Labour Office (ILO) methodology for CXR and International Classification of HRCT for Occupational and Environmental Respiratory Diseases. Accuracy of screening positive (ILO major category 1, 2 or 3) and negative (ILO major category 0) CXRs were compared with identification of radiological features of silicosis on HRCT.ResultsCXR was positive for silicosis in 27/110 (24.5%) workers and HRCT in 40/110 (36.4%). Of the 83 with a negative CXR (ILO category 0), 15 (18.1%) had silicosis on HRCT. All 11 workers with ILO category 2 or 3 CXRs had silicosis on HRCT. In 99 workers ILO category 0 or 1 CXRs, the sensitivity of screening positive CXR compared to silicosis identified by HRCT was 48% (95%CI 29–68) and specificity 97% (90–100).ConclusionCompared to HRCT, sensitivity of CXR was low but specificity was high. Reliance on CXR for health monitoring would provide false reassurance for many workers, delay management and underestimate the prevalence of silicosis in the artificial stone benchtop industry.
The scope of practice of geriatric dentistry in British Columbia (Canada): An exploratory study
Authors: Chen Alice , Wyatt Chris C. L. 
Published: May 2024

AbstractAimsThe oral health needs of frail older adults are increasing with an aging population in Canada. The objective of this study was to explore the perceptions of dentists in British Columbia regarding their view of geriatric dentistry as a distinct scope of practice and in relation to special needs dentistry.Methods and resultsQualitative data were gathered thorough semi guided interviews of a purposeful sample of dental clinicians, educators and members of organized dentistry with specialized knowledge of oral health for frail older adults. Interviews were transcribed, coded, and analyzed using a thematic approach. Thematic saturation was reached with the 10 participants in this study. Through the method of interpretative description, patient, dentist, and systemic factors that shaped scope of practice for geriatric dentistry were identified as well as the broader skill sets required for geriatric dentistry.ConclusionThe study found that participants perceived geriatric dentistry as unique scope of practice from general dentistry requiring special knowledge in the management of challenges associated with aging with frailty as well as the ability to work in long‐term care. Similar to special needs dentistry, geriatric dentistry requires person‐centered care and emphasized the need for interprofessional collaboration in alternative care settings.
Fuzzy Uncertainty Analysis of a Fractional Order Human Immunodeficiency Virus Dynamic Model With Type-1 and Interval Type-2 Parameters
Authors: Mohapatra Dhabaleswar , Chakraverty S. 
Published: May 2024

Abstract
In recent years, the study of mathematical models for the human immunodeficiency virus (HIV) has attracted considerable interest due to its importance in comprehending and combating the propagation of the virus. Typically, the model's governing equations are a system of ordinary differential equations. In order to explain the inheritance behavior, fractional order HIV models may be more helpful than integer order models. In addition, the presence of uncertainty in real-world phenomena can not be avoided, and fuzzy numbers are of great use in these scenarios. In view of the above, the numerical solution of the fuzzy fractional order HIV model is analyzed in this paper. The model takes into account the interactions between susceptible, asymptomatic, and symptomatic populations, as well as the effects of fractional order derivatives and fuzzy uncertainty. Here, the differentiation of the fuzzy parameters is considered in granular sense. The uncertain model parameters are addressed with triangular fuzzy numbers (TFNs) and interval type-2 triangular fuzzy numbers (IT2TFNs). The use of interval type-2 fuzzy numbers rather than type-1 fuzzy numbers to express the imprecise parameters may be helpful in some instances where the membership grade is unclear. The generalized modified Euler method (GMEM) is used to derive the corresponding solutions. Lastly, the behavior of various populations in crisp as well as uncertain environments is also studied using graphical results.
Combination of anti-SSA/Ro60 and anti-dsDNA serotype is predictive of belimumab renal response in patients with lupus nephritis
Authors: Zhao Liling , Wang Wenwen , Wu Lijun , Wu Tong , Tu Jianxin , Wu Xue , Sun Fangfang , Ding Huihua , Shen Nan , Wu Huaxiang , Zhu Jing , Sun Li , Ye Shuang 
Published: May 2024

ObjectivesTo investigate the effectiveness of belimumab on active lupus nephritis (LN) and explore the predictors, including serological biomarkers, of renal response to belimumab in a real-world setting.MethodsThis multicentre, real-world observational study enrolled patients with active LN receiving intravenous belimumab as an add-on therapy with 24-hour urine protein≥1 g and estimated glomerular filtration rate≥30 mL/min/1.73 m2at baseline. Complete renal response (CRR), partial renal response (PRR), no renal response (NRR) and primary efficacy renal response (PERR) were evaluated. Multivariable logistic regression was used to identify risk factors for NRR to belimumab at 6 months.ResultsAmong the 122 patients enrolled, the proportions of patients achieving CRR, PRR, NRR and PERR were 35.9%, 17.1%, 47.0% and 44.4% at 6 months (n=117) and 55.6%, 19.4%, 26.4% and 58.3% at 12 months (n=72), respectively. Proteinuria, daily prednisone dosage and Systemic Lupus Erythematosus Disease Activity Index 2000 scores significantly decreased at 6 and 12 months (p<0.0001). NRR at 6 months (NRR6) was the strongest negative predictor of CRR at 12 months. Baseline anti-dsDNA positivity inversely predicted NRR6 (OR=0.32,95% CI=0.10 to 0.98, p=0.049), while anti-SSA/Ro60 positively predicted NRR6 (OR=3.16, 95% CI=1.14 to 8.74, p=0.027). The combination of anti-SSA/Ro60 and anti-dsDNA serotype quantitatively predicted belimumab renal response.ConclusionThe effectiveness of belimumab was reproducible in Chinese patients with active LN. The simple yet interesting serotype predictive model needs further validation and its possible underlying mechanistic relevance deserves further exploration.
Dysregulation of circulating collagen turnover markers in very early systemic sclerosis
Authors: Dobrota Rucsandra , Jordan Suzana , Juhl Pernille , Del Papa Nicoletta , Maurer Britta , Becker Mike , Mihai Carina , Bay-Jensen Anne-C , Karsdal Morten Asser , Siebuhr Anne Sofie , Distler Oliver 
Published: May 2024

ObjectiveClinical observation suggests that vascular activation and autoimmunity precede remodelling of the extracellular matrix (ECM) in systemic sclerosis (SSc). We challenge this paradigm by hypothesising that ECM biomarkers are already disturbed in patients with very early SSc (veSSc) when fibrosis is not yet clinically detectable.Methods42 patients with veSSc, defined as the presence of Raynaud’s phenomenon and at least one of puffy fingers, positive antinuclear antibodies or pathological nailfold capillaroscopy, not meeting the 2013 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for SSc, were compared with healthy controls (HCs, n=29). ECM degradation (BGM, C3M, C4M and C6M) and ECM formation biomarkers (PRO-C3, PRO-C4 and PRO-C5) were measured in serum using ELISAs. A cross-sectional analysis at baseline and a longitudinal analysis was performed.ResultsCompared with HC, veSSc patients showed a strongly dysregulated turnover of type III and IV collagens (higher C3M, C4M, both p<0.0001 and PRO-C3, p=0.004, lower turnover ratios PRO-C3/C3M and PRO-C4/C4M, both p<0.0001). The biglycan degradation biomarker BGM was higher in veSSc than in HC (p=0.006), whereas the degradation biomarker for type VI collagen, C6M, was lower (p=0.002). In an ROC analysis, biomarkers of type III and IV collagen excellently distinguished between veSSc and HC: C3M, AUC=0.95, p<0.0001; C4M, AUC=0.97, p<0.0001; turnover ratios PRO-C3/C3M, AUC=0.80, p<0.0001; PRO-C4/C4M, AUC=0.97; p<0.0001.ConclusionThese findings indicate ECM remodelling as a very early phenomenon of SSc occurring in parallel with microvascular and autoimmune changes. Biomarkers of type III and IV collagens distinguished between veSSc patients and HC, indicating them as potential biomarkers for the detection of veSSc.
Method summaries for JPF
Authors: Berglund Lasse , Artho Cyrille 
Published: May 2024

Java Path nder (JPF) is a virtual machine executing Java byte- code that is able to perform model checking using backtracking execution. Due to backtracking, parts of a program may be ex- ecuted multiple times during model checking. Hence, we explore whether method summaries can be used to make JPF's model checking more efficient. We present the design and implementa- tion of dynamically generated summaries as an extension of JPF.
While our summaries incur an overhead that outweighs the bene- ts in most cases, the approach shows promise in certain cases, in particular when stateless model checking is used. We also provide some results related to cases when our summaries are applicable that could provide guidance for future work within this eld.
Cardiovascular Complications With Delivery Hospitalizations in Patients With Pulmonary Hypertension: A Nationwide Study From 2011 to 2020
Authors: Agrawal Ankit , Bajaj Suryansh , Bhagat Umesh , Yesilyaprak Abdullah , Chandna Sanya , Arockiam Aro Daniela , Jamil Yasser , El Iskandarani Mahmoud , Gupta Rahul , Majid Muhammad , Nayar Divya , Michos Erin D. 
Published: May 2024

Background
Pregnancy in patients with pulmonary hypertension (PH) is associated with a heightened risk of medical complications including right heart failure, pulmonary edema, and arrhythmias. Our study investigated the association between PH and these complications during delivery.

Methods and Results

The National Inpatient Sample was used to identify delivery hospitalizations from 2011 to 2020. Multivariable logistic regression was performed to study the association of PH with the primary outcomes of in‐hospital medical and obstetric complications. A total of 37 482 207 delivery hospitalizations in women ≥18 years of age were identified, of which 9593 patients had PH. Pregnant patients with PH had higher incidence of complications during delivery including preeclampsia/eclampsia, arrhythmias, and pulmonary edema among others, compared with those without PH. Pregnant patients with PH also had a higher incidence of in‐hospital mortality compared with those without PH (0.51% versus 0.007%). In propensity‐matched analyses, PH was still significantly associated with a higher risk of in‐hospital mortality (odds ratio [OR], 5.02 [95% CI, 1.82–13.90];
P
=0.001), pulmonary edema (OR, 9.11 [95% CI, 6.34–13.10];
P
<0.001), peripartum cardiomyopathy (OR, 1.85 [95% CI, 1.37–2.50];
P
<0.001), venous thromboembolism (OR, 12.60 [95% CI, 6.04–26.10];
P
<0.001), cardiac arrhythmias (OR, 6.11 [95% CI, 4.97–7.53];
P
<0.001), acute kidney injury (OR, 3.72 [95% CI, 2.86–4.84];
P
<0.001), preeclampsia/eclampsia (OR, 2.24 [95% CI, 1.95–2.58];
P
<0.001), and acute coronary syndrome (OR, 2.01 [95% CI, 1.06–3.80];
P
=0.03), compared with pregnant patients without PH.

Conclusions
Delivery hospitalizations in patients with PH are associated with a high risk of mortality, pulmonary edema, peripartum cardiomyopathy, venous thromboembolism, arrhythmias, acute kidney injury, preeclampsia/eclampsia, and acute coronary syndrome.
On the Meditation Sutra of Dharmatrāta, Buddhabhadra’s Profile, and the Primordial State
Authors: Mohr Michel 
Published: May 2024

Abstract
This article focuses on the Damoduoluo chanjing 達摩多羅禪經 [Meditation Sutra of Dharmatrāta], a text completed around 411 CE. This article focuses first on the central figure associated with it, Buddhabhadra [Fotuobatuoluo 佛馱跋陀羅] (359–429), geographical issues linked with him, and the historical context, before discussing and unpacking a few portions of the text about mindfulness with breathing.
The MSD not only discusses some of the obstacles encountered on the path toward mastery, according to the preliminary way and the advanced way, but it also emphasizes how this practice leads to a stage called “primordial state”. Such a state cannot be accurately described by speaking of confirmatory vision or confirmatory experience because it coincides with rediscovering the intrinsic luminosity of consciousness, which precisely coincides with the cessation of all discursive experience. This article challenges the idea that a single overarching theory can account for the increasing popularity of meditation techniques in the Sinosphere during the early fifth century. Scrutinizing the accounts about cultivation that mushroomed in the early fifth century and highlighting one of their facets as expressed in the MSD serves to emphasize their diversity.
Predicting Unplanned Readmissions to the Intensive Care Unit in the Trauma Population
Authors: O’Quinn Payton C. , Gee Kaylan N. , King Sarah A. , Yune Ji-Ming J. , Jenkins Jacob D. , Whitaker Fiona J. , Suresh Sapna , Bollig Reagan W. , Many Heath R. , Smith Lou M. 
Published: May 2024

Background: Unplanned readmission to intensive care units (UR-ICU) in trauma is associated with increased hospital length of stay and significant morbidity and mortality. We identify independent predictors of UR-ICU and construct a nomogram to estimate readmission probability. Materials and Methods: We performed an IRB-approved retrospective case-control study at a Level I trauma center between January 2019 and December 2021. Patients with UR-ICU (n = 175) were matched with patients who were not readmitted (NR-ICU) (n = 175). Univariate and multivariable binary linear regressionanalyses were performed (SPSS Version 28, IBM Corp), and a nomogram was created (Stata 18.0, StataCorp LLC). Results: Demographics, comorbidities, and injury- and hospital course-related factors were examined as potential prognostic indicators of UR-ICU. The mortality rate of UR-ICU was 22.29% vs 6.29% for NR-ICU ( P < .001). Binary linear regression identified seven independent predictors that contributed to UR-ICU: shock ( P < .001) or intracranial surgery ( P = .015) during ICU admission, low hematocrit ( P = .001) or sedation administration in the 24 hours before ICU discharge ( P < .001), active infection treatment ( P = .192) or leukocytosis on ICU discharge ( P = .01), and chronic obstructive pulmonary disease (COPD) ( P = .002). A nomogram was generated to estimate the probability of UR-ICU and guide decisions on ICU discharge appropriateness. Discussion: In trauma, UR-ICU is often accompanied by poor outcomes and death. Shock, intracranial surgery, anemia, sedative administration, ongoing infection treatment, leukocytosis, and COPD are significant risk factors for UR-ICU. A predictive nomogram may help better assess readiness for ICU discharge.
Ultrasound-guided Axillary Artery Catheter Placement and Associated Complications in Critically Ill Patients
Authors: Cardona Stephanie , Gross Aliza S. , Yu Allen T. , Bassily-Marcus Adel , Oropello John , Manasia Anthony 
Published: May 2024

Background Arterial catheter placement for hemodynamic monitoring is commonly performed in critically ill patients. The radial and femoral arteries are the two sites most frequently used; there is limited data on the use of the axillary artery for this purpose. The aim of this study was to investigate the rate of complications from ultrasound-guided axillary artery catheter placement in critically ill patients. Methods A retrospective study at a tertiary care center of patients admitted to an intensive care unit who had ultrasound-guided axillary artery catheter placement during admission. Primary outcome of interest was catheter related complications, including bleeding, vascular complications, compartment syndrome, stroke or air embolism, catheter malfunction, and need for surgical intervention. Results This study identified 88 patients who had an ultrasound-guided axillary artery catheter placed during their admission. Of these 88, nine patients required multiple catheters placed, for a total of 99 axillary artery catheter placement events. The median age was 64 [IQR 48, 71], 41 (47%) were female, and median body mass index (BMI) was 26 [IQR 22, 30]. The most common complication was minor bleeding (11%), followed by catheter malfunction (2%), and vascular complications (2%). Univariate analyses did not show any association between demographics and clinical variables, and complications related to axillary arterial catheter. Conclusion The most common complication found with ultrasound-guided axillary artery catheter placement was minor bleeding, followed by catheter malfunction, and vascular complications. Ultrasound-guided axillary arterial catheters are an alternative in patients in whom radial or femoral arterial access is difficult or not possible to achieve.
RAS/RAF/MAPK Pathway Mutations as Predictive Biomarkers in Middle Eastern Colorectal Cancer: A Systematic Review
Authors: Benmokhtar Soukaina , Laraqui Abdelilah , Hilali Farida , Bajjou Tahar , El Zaitouni Sara , Jafari Meryem , Baba Walid , Elannaz Hicham , Lahlou Idriss Amine , Hafsa Chahdi , Oukabli Mohamed , Mahfoud Tarik , Tanz Rachid , Ichou Mohamed , Ennibi Khaled , Dakka Nadia , Sekhsokh Yassine 
Published: May 2024

Background: This review article aims to investigate the prevalence and spectrum of rat sarcoma (RAS) and V-Raf Murine Sarcoma Viral Oncogene Homolog B (BRAF) mutations, and their connection with geographical location, clinicopathological features, and other relevant factors in colorectal cancer (CRC) patients in the Middle East. Methods: A systematic literature review, employing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework, was conducted to investigate the association between the frequency of relevant mutations and the descriptive clinicopathological characteristics of CRC patients. Multiple electronic databases, including PubMed, Science Direct, Web of Science, Scopus, and Google Scholar, were searched to analyze the relevant literature. Results: A total of 19 eligible studies comprising 2960 patients with CRC were included in this review. A comprehensive analysis of the collected literature data as well as descriptive and methodological insights is provided. Men were predominant in reviewed studies for the region, accounting for 58.6%. Overall, RAS mutation prevalence was 38.1%. Kirsten RAS Viral Oncogene Homolog (KRAS) mutations were the most common, accounting for 37.1% of cases and distributed among different exons, with the G12D mutation being the most frequent in exon 2 (23.2%) followed by G12V (13.7%), G13D (10.1%), G12C (5.1%), G12A (5.04%), and G12S (3.6%). Neuroblastoma RAS Viral Oncogene Homolog (NRAS) mutations were identified in 3.3% of tumor samples, with the most common mutation site located in exons 2, 3, and 4, and codon 61 being the most common location for the region. The total mutation frequency in the BRAF gene was 2.6%, with the V600E mutation being the most common. Conclusion: The distribution patterns of RAS and BRAF mutations among CRC patients exhibit notable variations across diverse ethnic groups. Our study sheds light on this phenomenon by demonstrating a higher prevalence of KRAS mutations in CRC patients from the Middle East, as compared with those from other regions. The identification of these mutations and geographical differences is important for personalized treatment planning and could potentially aid in the development of novel targeted therapies. The distinct distribution patterns of RAS and BRAF mutations among CRC patients across different ethnic groups, as well as the regional variability in mutation prevalence, highlight the need for further research in this area.
Refining Operative Indications for Zygomaticomaxillary Complex Fracture Repair
Authors: Goli Rachna , Rao Vinay , Crozier Joseph W. , Woo Albert S. 
Published: May 2024

Study Design Case-control. Objective Although zygomaticomaxillary complex (ZMC) fractures are among the most common facial injuries, the optimal approach to management remains controversial. This study analyzes the relationship between displacement measures derived from pre-operative CT imaging and clinical symptomatology to enhance surgeon understanding of the need for operative intervention. Methods A retrospective analysis was conducted on 95 patients with ZMC fractures seen at a single institution between 2015 and 2020. Patient demographics, CT characteristics, and symptoms prompting surgery were recorded from the medical record. Statistical analysis was conducted to determine relationships between radiographic characteristics, symptomatology, and need for operative intervention. Results Malar flattening or facial asymmetry was significantly predicted by lateral maxillary wall impaction (OR = 1.36 , P < .001) and anterior-posterior displacement (OR = 1.18, P = .01). Infraorbital rim step-off was significantly associated with lateral maxillary wall impaction (OR = 1.23, P < .01). Vertical displacement predicted complaint of malocclusion (OR = 1.47, P = .03). Moreover, fractures with posterior displacement greater than 2.5 mm (OR = 14.3, P < .001) or lateral maxillary wall impaction greater than 4.5 mm (OR = 12.0, P < .001) were significantly more likely to be considered operative. Fractures displaced less than 15 mm total in all directions (OR = 16.0, P < .001) were less likely to require surgery. Conclusions CT characteristics of ZMC fractures reliably predict a patient’s likelihood of developing symptoms, indicating surgical intervention. We hope these findings will aid in surgical decision-making regarding the management of ZMC fractures.