bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accommodating the Rise in Urbanisation: Are New Towns a Good Solution?
Authors: Loumeau Gabriel 
Published: May 2024

Abstract
This paper studies the performance of New Towns, that is, planned large urban sub-centres, as a central tool to accommodate the global rise in urbanisation. A spatial quantifiable general equilibrium framework suitable to study large-scale urban master plans is presented. The framework is then used to investigate the equilibrium effects of five New Towns developed in the 1970s in Paris’s metropolitan area. By 2015, the development of New Towns appears to have increased metropolitan population ($+$18%), metropolitan gross domestic product ($+$11%) and reduced average commuting times (−6.9%). The results obtained for Paris’s metropolitan area are externally validated using a difference-in-differences approach on all 314 New Towns developed worldwide between 1992 and 2012.
Initial clinical experience with the balloon-in-basket pulsed field ablation system: acute results of the VOLT CE mark feasibility study
Authors: Sanders Prashanthan , Healy Stewart , Emami Mehrdad , Kotschet Emily , Miller Amber , Kalman Jonathan M 
Published: May 2024

Abstract

Aims
Pulsed field ablation (PFA) for the treatment of atrial fibrillation (AF) potentially offers improved safety and procedural efficiencies compared with thermal ablation. Opportunities remain to improve effective circumferential lesion delivery, safety, and workflow of first-generation PFA systems. In this study, we aim to evaluate the initial clinical experience with a balloon-in-basket, 3D integrated PFA system with a purpose-built form factor for pulmonary vein (PV) isolation.

Methods and results
The VOLT CE Mark Study is a pre-market, prospective, multi-centre, single-arm study to evaluate the safety and effectiveness of the Volt™ PFA system for the treatment of paroxysmal (PAF) or persistent AF (PersAF). Feasibility sub-study subjects underwent phrenic nerve evaluation, endoscopy, chest computed tomography, and cerebral magnetic resonance imaging. Study endpoints were the rate of primary serious adverse event within 7 days and acute procedural effectiveness. A total of 32 subjects (age 61.6 ± 9.6 years, 65.6% male, 84.4% PAF) were enrolled and treated in the feasibility sub-study and completed a 30-day follow-up. Acute effectiveness was achieved in 99.2% (127/128) of treated PVs (96.9% of subjects, 31/32) with 23.8 ± 4.2 PFA applications/subject. Procedure, fluoroscopy, LA dwell, and transpired ablation times were 124.6 ± 28.1, 19.8 ± 8.9, 53.0 ± 21.0, and 48.0 ± 19.9 min, respectively. Systematic assessments of initial safety revealed no phrenic nerve injury, pulmonary vein stenosis, or oesophageal lesions causally related to the PFA system and three subjects with silent cerebral lesions (9.4%). There were no primary serious adverse events.

Conclusion
The initial clinical use of the Volt PFA System demonstrates acute safety and effectiveness in the treatment of symptomatic, drug refractory AF.
The Association Between Cardiometabolic Risk and Cognitive Function Among Older Americans and Chinese
Authors: Wu Qiao , Ailshire Jennifer A , Kim Jung Ki , Crimmins Eileen M 
Published: May 2024

Abstract

Background
Cardiometabolic risk (CMR) is associated with cognitive health, but the association can be affected by broader social, economic, and medical contexts. The United States and China have very different developmental and epidemiological histories, and thus CMR among older people could be linked to cognitive function differently in the 2 countries.

Methods
Cross-sectional and longitudinal ordinary least squares regression models were estimated for each country using nationally representative samples of populations over age 50: 7 430/4 474 Americans and 6 108/3 655 Chinese in the cross-sectional/longitudinal samples.

Results
In the United States, higher CMR is associated with worse cognitive function (b = −0.08, p &lt; .016). Longitudinally, CMR increase is associated with worse cognitive function at a marginally significant level (b = −0.10, p = .055). No relationship between CMR level or change and cognitive function is observed in China. Higher education levels are linked to better cognitive function and slower cognitive decline in both countries. Unlike older Americans, relative to those with very low education levels, among older Chinese with the highest education level, a higher CMR links to better cognitive function (b = 0.63, p = .013) and slower cognitive decline (b = 0.35, p = .062); Nevertheless, a rapid increase in CMR is additionally harmful (b = −0.54, p = .050) for cognitive function and may lead to faster cognitive decline (b = −0.35, p = .079).

Conclusions
The significant relationship between CMR and cognitive function in the United States suggests the importance of monitoring and controlling CMR factors at older ages. The insignificant relationship in China may be explained by the high CMR among those with high education levels, highlighting the need for improving cardiometabolic health through education and promoting healthy lifestyles.
Addressing the Black Box of AI—A Model and Research Agenda on the Co-constitution of Aging and Artificial Intelligence
Authors: Gallistl Vera , Banday Muneeb Ul Lateef , Berridge Clara , Grigorovich Alisa , Jarke Juliane , Mannheim Ittay , Marshall Barbara , Martin Wendy , Moreira Tiago , Van Leersum Catharina Margaretha , Peine Alexander 
Published: May 2024

Abstract
Algorithmic technologies and (large) data infrastructures, often referred to as Artificial Intelligence (AI), have received increasing attention from gerontological research in the last decade. Although there is much literature that dissects and explores the development, application, and evaluation of AI relevant to gerontology, this study makes a novel contribution by critically engaging with the theorizing in this growing field of research. We observe that gerontology’s engagement with AI is shaped by an interventionist logic that situates AI as a black box for gerontological research. We demonstrate how this black box logic has neglected many aspects of AI as a research topic for gerontology and discuss three classical concepts in gerontology to show how they can be used to open various black boxes of aging and AI in the areas: (a) the datafication of aging, (b) the political economy of AI and aging, and (c) everyday engagements and embodiments of AI in later life. In the final chapter, we propose a model of the co-constitution of aging and AI that makes theoretical propositions to study the relational terrain between aging and AI and hence aims to open the black box of AI in gerontology beyond interventionist logic.
Disparities in telemedicine use among Native Hawaiian and Pacific Islander individuals insured through Medicaid
Authors: Morenz Anna M , Reddy Ashok , Hsu Amy , Le Anh , Wong Edwin S , Liao Joshua M 
Published: May 2024

Abstract
States have implemented policy changes to increase access to telemedicine services for individuals receiving Medicaid benefits. Native Hawaiian and Pacific Islander (NHPI) individuals experienced disproportionate harms from COVID-19 and have long experienced disparities in health care access compared with other racial and ethnic groups, making the issue of telemedicine access particularly salient for NHPI individuals on Medicaid. Utilizing 100% 2020–2021 Medicaid claims, we compared trends in telemedicine use between NHPI and non-Hispanic White individuals on Medicaid in Washington State and conducted a decomposition analysis to identify drivers of underlying disparities. In both years, NHPI individuals were 38%–39% less likely to use any telemedicine than White individuals after adjusting for patient- and area-level characteristics. Decomposition analysis revealed that most of this difference was due to differential effects of characteristics, rather than group differences in characteristics. Namely, several characteristics that were associated with increased telemedicine use had more muted associations for NHPI vs White individuals, such as English as the primary spoken language and female sex. These findings suggest the presence of limited acceptability of or group-specific barriers to telemedicine for NHPI individuals, including potential discrimination in being offered telemedicine visits. These issues should be understood and mitigated through close collaboration between health care leaders and NHPI communities.
Contextual Impartiality: A New Approach to Assessing Impartiality in Investor-State Dispute Settlement
Authors: Brekoulakis Stavros , Howard Anna 
Published: May 2024

Abstract
This article proposes a new approach to assessing impartiality in investor-State dispute settlement (ISDS). It builds on earlier work that criticises the current doctrine of impartiality in ISDS which applies irrespective of the role and context in which arbitrators are called to decide a dispute. Drawing on empirical findings, moral philosophy and psychology, this article proposes the idea of contextual impartiality. As is argued, a contextual approach offers an understanding of impartiality which better corresponds to the foundational value of trust in ISDS which is founded on the method of party appointment of arbitrators. Under this approach, the question is not whether an arbitrator can meet universal standards of impartiality irrespective of the context within which the arbitrator operates. Rather, the critical distinction is between permissible and impermissible partiality which depends on whether the individual is reasonably expected to act partially because of their circumstances. In this respect, the article identifies open-mindedness as a fundamental feature of a contextual approach to impartiality and a bright line between permissible and impermissible partiality.
Drug Concentrations in Hair and Dried Blood Spots as Preexposure Prophylaxis Adherence Metrics During Pregnancy and Postpartum
Authors: Wu Linxuan , Kinuthia John , Anderson Peter L , Baeten Jared M , Dettinger Julia C , Gandhi Monica , Gomez Laurén , John-Stewart Grace , Marwa Mary M , Ngumbau Nancy , Otieno Felix , Omondi Pascal , Odhiambo Ben , Watoyi Salphine , Pintye Jillian 
Published: May 2024

AbstractWe evaluated hair tenofovir (TFV) concentrations as an adherence metric for HIV preexposure prophylaxis during pregnancy and postpartum and compared hair levels with TFV-diphosphate levels in dried blood spots (DBSs). Overall 152 hair samples from 102 women and 36 hair-DBS paired samples from 29 women were collected from a subset of women in a cluster-randomized trial. Having a partner with HIV was associated with higher hair TFV levels (P &lt; .001). Hair TFV concentrations were strongly correlated with DBS TFV-diphosphate levels (r = 0.76, P &lt; .001), indicating hair as a promising cumulative adherence metric for perinatal preexposure prophylaxis assessment.
Morphological Diversity of Turtle Hyoid Apparatus is Linked to Feeding Behavior
Authors: Jorgewich-Cohen G , Werneburg I , Jobbins M , Ferreira G S , Taylor M D , Bastiaans D , Sánchez-Villagra M R 
Published: May 2024

Synopsis
The hyoid apparatus of tetrapods is highly diverse in its morphology. It plays an important role in feeding, breathing, sound production, and various other behaviors. Among turtles, the diversity of the hyoid apparatus has been recurrently linked to their habitat. The ossification of the hyoid corpus is often the main trait used in correlations with “niche” occupancy, an ossified corpus being associated with aquatic environments and a cartilaginous corpus with terrestrial life. Most studies conducted so far have focused on species belonging to Testudinoidea, the clade that occupies the biggest diversity of habitats (i.e., terrestrial, semi-terrestrial, and aquatic animals), while other turtle lineages have been largely understudied. We assessed the adult anatomy of the hyoid apparatus of 92 turtle species from all “families”, together with ossification sequences from embryological series of 11 species, some described for the first time here. Using nearly 40 different discrete anatomical characters, we discuss the evolutionary patterns and the biological significance of morphological transformations in the turtle hyoid elements. Morphological changes are strongly associated to feeding modes, with several instances of convergent evolution within and outside the Testudines clade, and are not as strongly connected to habitat as previously thought. Some of the hyoid character states we describe are diagnostic of specific turtle clades, thus providing phylogenetically relevant information.
How Bashar al-Asad Learned to Stop Worrying and Love the “War on Terror”
Authors: Lee Sean 
Published: May 2024

Abstracts
This article draws on regime newspaper archives and the Arabic-language speeches of and interviews with Syrian president Bashar al-Asad over the last two decades to track how Syrian governmental rhetoric on the question of “terrorism” has changed over time. Engaging with the literature on how ideas, technologies, and contentious repertoires diffuse and spread and how regimes learn from each other, I show how the Asad regime has moved from a discourse that saw “terrorism” as a Western and/or Israeli concept used to delegitimize primarily Palestinian and Lebanese resistance sponsored by Damascus to a discourse that embraces the rhetoric of the “war on terror” in order to legitimize the regime's counterinsurgency policies during the current conflict. I argue that this rhetorical shift is dependent on the ethno-sectarian identity of the population in question through a comparison of regime rhetoric on three separate uprisings in recent Syrian history: the current uprising (2011–present); the Kurdish uprising of 2004; and the Druze uprising in 2000. Since the current uprising is seen as a predominantly Sunni Arab affair, the Syrian regime has used “war on terror” rhetoric in ways that it did not during the Kurdish and Druze uprisings. I then situate this rhetorical move in time as a post-9/11 development by comparing current regime rhetoric with that of the Hafez al-Asad regime's rhetoric during the uprising centered in Hama in the late 1970s and early 1980s.
Machine learning to predict notes for chart review in the oncology setting: a proof of concept strategy for improving clinician note-writing
Authors: Jiang Sharon , Lam Barbara D , Agrawal Monica , Shen Shannon , Kurtzman Nicholas , Horng Steven , Karger David R , Sontag David 
Published: May 2024

Abstract

Objective
Leverage electronic health record (EHR) audit logs to develop a machine learning (ML) model that predicts which notes a clinician wants to review when seeing oncology patients.

Materials and Methods
We trained logistic regression models using note metadata and a Term Frequency Inverse Document Frequency (TF-IDF) text representation. We evaluated performance with precision, recall, F1, AUC, and a clinical qualitative assessment.

Results
The metadata only model achieved an AUC 0.930 and the metadata and TF-IDF model an AUC 0.937. Qualitative assessment revealed a need for better text representation and to further customize predictions for the user.

Discussion
Our model effectively surfaces the top 10 notes a clinician wants to review when seeing an oncology patient. Further studies can characterize different types of clinician users and better tailor the task for different care settings.

Conclusion
EHR audit logs can provide important relevance data for training ML models that assist with note-writing in the oncology setting.
Three-year effect of bisphosphonates on bone mineral density after denosumab withdrawal: observations from a real-world study
Authors: Farias Vanina , Jerkovich Fernando , Barragán Andrea Morejón , Pereyra Alejandro , Pernas Mariana González , Abdala Rubén , Longobardi Vanesa , Zanchetta María Belén 
Published: May 2024

Abstract
Data on long-term treatment regimens for preventing bone mineral density (BMD) loss that occurs after denosumab (Dmab) withdrawal are scarce. Our aim was to evaluate the long-term changes (12–36 months) in BMD and bone turnover markers in a group of postmenopausal women who had been treated with Dmab and received subsequent treatment with bisphosphonates. Secondary objectives were to evaluate factors associated with BMD loss, to compare the BMD change in patients who received oral vs intravenous bisphosphonates, and to assess the frequency of fragility fractures after Dmab discontinuation. The clinical data of 54 patients, 26 of whom had clinical and DXA assessments at 36 months, were analyzed. After 12 months, the mean LS BMD had decreased by 2.8% (±5.0), FN BMD by 1.9% (±5.8), and TH BMD by 1.9% (±3.7). After 36 months, LS BMD had decreased by 3.7% (±6.7), FN BMD by 2.5% (±7.1), and TH BMD by 3.6% (±5.2). C-terminal cross-linked telopeptide of type I collagen significantly increased during the first 12 months after Dmab withdrawal but then decreased at 36 months. BMD loss at 12 months was higher in patients with more than 30 months of Dmab treatment, but this difference was only statistically significant at FN (−3.3% vs −0.3%, P = .252 at LS, −3.3% vs 0.3%, P = .033 at FN, and −2.1% vs 0.9, P = .091 at TH). There were no statistically significant differences regarding the change in BMD at 12 and 36 months between oral and intravenous treatment. Seven patients suffered incidental vertebral fractures (clinical vertebral fractures: n = 6, morphometric fractures: n = 1) three of which were multiple. None of these patients were treated following international or institutional guidelines or recommendations. In summary, our study suggests that bisphosphonates can help maintain BMD for 36 months after Dmab discontinuation.
In Search of Priestly Witness: A Barthian Intervention in the Chinese Church–State Relationship in a Neoliberal Age
Authors: Li Quan 
Published: May 2024

Abstract
This article suggests a theological proposal for envisioning the relationship between the church and state in the context of the Chinese neoliberal regime. It consists of three interrelated tasks. First, I argue that the rise of a neoliberal state has shaped the Chinese political landscape over the past four decades and constrained the collective responses of the Chinese house churches in their cooperative and negotiating strategies. Then, I examine two recent theological announcements by the church leaders and evaluate their strengths and weaknesses in addressing the principles of church–state relations. This critical analysis is followed by a rediscovery of Barth’s theological politics of priestly witness, which has laid the Christological foundation for the integrity of faith communities and shed light on their primary concerns and actions towards the Chinese neoliberal state. In this way, I seek to contribute to the ongoing discussion of Chinese political theology by offering a nascent analysis of the political system encountered by the house churches and reclaiming Barth’s theological legacy for these churches in public witness.
Reduction of Wolbachia in Diaphorina citri (Hemiptera: Liviidae) increases phytopathogen acquisition and decreases fitness
Authors: Roldán Erik L , Stelinski Lukasz L , Pelz-Stelinski Kirsten S 
Published: May 2024

Abstract
Wolbachia pipientis is a maternally inherited intracellular bacterium that infects a wide range of arthropods. Wolbachia can have a significant impact on host biology and development, often due to its effects on reproduction. We investigated Wolbachia-mediated effects in the Asian citrus psyllid, Diaphorina citri Kuwayama, which transmits Candidatus Liberibacter asiaticus (CLas), the causal agent of citrus greening disease. Diaphorina citri are naturally infected with Wolbachia; therefore, investigating Wolbachia-mediated effects on D. citri fitness and CLas transmission required artificial reduction of this endosymbiont with the application of doxycycline. Doxycycline treatment of psyllids reduced Wolbachia infection by approximately 60% in both male and female D. citri. Psyllids treated with doxycycline exhibited higher CLas acquisition in both adults and nymphs as compared with negative controls. In addition, doxycycline-treated psyllids exhibited decreased fitness as measured by reduced egg and nymph production as well as adult emergence as compared with control lines without the doxycycline treatment. Our results indicate that Wolbachia benefits D. citri by improving fitness and potentially competes with CLas by interfering with phytopathogen acquisition. Targeted manipulation of endosymbionts in this phytopathogen vector may yield disease management tools.
Eosinophil biology from the standpoint of metabolism: implications for metabolic disorders and asthma
Authors: Haruna Nana-Fatima , Berdnikovs Sergejs , Nie Zhenying 
Published: May 2024

Abstract
Eosinophils, recognized for their immune and remodeling functions and participation in allergic inflammation, have recently garnered attention due to their impact on host metabolism, especially in the regulation of adipose tissue. Eosinophils are now known for their role in adipocyte beiging, adipokine secretion, and adipose tissue inflammation. This intricate interaction involves complex immune and metabolic processes, carrying significant implications for systemic metabolic health. Importantly, the interplay between eosinophils and adipocytes is bidirectional, revealing the dynamic nature of the immune–metabolic axis in adipose tissue. While the homeostatic regulatory role of eosinophils in adipose tissue is appreciated, this relationship in the context of obesity or allergic inflammation is much less understood. Mechanistic details of eosinophil–adipose interactions, especially the direct regulation of adipocytes by eosinophils, are also lacking. Another poorly understood aspect is the metabolism of the eosinophils themselves, encompassing metabolic shifts during eosinophil subset transitions in different tissue microenvironments, along with potential effects of host metabolism on the programming of eosinophil hematopoiesis and the resulting plasticity. This review consolidates recent research in this emerging and fascinating frontier of eosinophil investigation, identifying unexplored areas and presenting innovative perspectives on eosinophil biology in the context of metabolic disorders and associated health conditions, including asthma.
The AHR repressor limits expression of antimicrobial genes but not AHR-dependent genes in intestinal eosinophils
Authors: Weighardt Heike , Shapiro Michael , Mayer Michelle , Förster Irmgard , Stockinger Brigitta , Diny Nicola Laura 
Published: May 2024

Abstract
Intestinal eosinophils express the aryl hydrocarbon receptor (AHR), an environmental sensor and ligand-activated transcription factor that responds to dietary or environmental ligands. AHR regulates tissue adaptation, survival, adhesion, and immune functions in intestinal eosinophils. The AHR repressor (AHRR) is itself induced by AHR and believed to limit AHR activity in a negative feedback loop. We analyzed gene expression in intestinal eosinophils from wild-type and AHRR knockout mice and found that AHRR did not suppress most AHR-dependent genes. Instead, AHRR limited the expression of a distinct small set of genes involved in the innate immune response. These included S100 proteins, antimicrobial proteins, and alpha-defensins. Using bone marrow–derived eosinophils, we found that AHRR knockout eosinophils released more reactive oxygen species upon stimulation. This work shows that the paradigm of AHRR as a repressor of AHR transcriptional activity does not apply to intestinal eosinophils. Rather, AHRR limits the expression of innate immune response and antimicrobial genes, possibly to maintain an anti-inflammatory phenotype in eosinophils when exposed to microbial signals in the intestinal environment.