bluuebunny/crossref_metadata_2025_split huggingface dataset:
Secoscabronine M, a novel diterpenoid from the Chinese bitter mushroom Sarcodon scabrosus
Authors: Shi Xin‐Wei , Zhang An‐Ling , Pescitelli Gennaro , Gao Jin‐Ming 
Published: April 2012

AbstractSecoscabronine M (1) is a hemiacetal cyathane diterpenoid that was isolated from the fruiting bodies of the basidiomycete Sarcodon scabrosus (Fr.) Karst. Compound 1 possesses a novel structure with a bond cleavage between C‐3 and C‐4. The structure of the new compound was elucidated by means of spectroscopic methods, including two‐dimensional nuclear magnetic resonance experiments. The absolute configuration of 1 was established by analysis of circular dichroism spectroscopy and also by employing time‐dependent density functional theory calculations. In addition, compound 1 was confirmed to be an equilibrium mixture of two epimers (15S and 15R) at position C‐15 in polar solvents by one‐dimensional nuclear magnetic resonance analysis. Chirality 4:386–390, 2012. © 2012 Wiley Periodicals, Inc.
Comparison of Air Filter Tests under Real Life and Lab Conditions
Authors: Schmidt Frank , Breidenbach Achim , Däuber Eckhard 
Published: April 2012

AbstractAufgrund des neuen Entwurfs der EN 779 und der damit verbundenen Einführung eines Mindestwirkungsgrades ist erneut eine heftige Diskussion über die Verwertbarkeit der im Labor ermittelten Wirkungsgrade von Filtern insbesondere im Vergleich zu Betriebsergebnissen entfacht. Deshalb wurden im Rahmen dieser Studie Filter drei bzw. sechs Monate in einer Lüftungsanlage eingebaut. Diese im Realbetrieb gealterten Filter wurden im normkonformen Prüfstand einer DEHS‐Effizienzmessung unterzogen, d. h. Druckverluste und Wirkungsgrade wurden ermittelt und mit Werten im Neuzustand verglichen. Es erfolgten weitere Versuche am Filterelement, die auf unterschiedlichen Verfahren zur Entladung des Filters (Beaufschlagung mit Isopropanol, Tensiden und Dieselruß) beruhen.
Effect of Telmisartan on Paroxysmal Atrial Fibrillation Recurrence in Hypertensive Patients With Normal or Increased Left Atrial Size
Authors: Fogari Roberto , Zoppi Annalisa , Maffioli Pamela , Mugellini Amedeo , Preti Paola , Perrone Tiziano , Derosa Giuseppe 
Published: April 2012

AbstractBackground:Hypertension is the most prevalent and potentially modifiable risk factor for atrial fibrillation (AF). In a previous secondary prevention study, the authors observed that the angiotensin II receptor blocker telmisartan was more effective than the calcium channel blocker amlodipine in preventing AF relapse in hypertensive patients with normal atrial size.Hypothesis:Telmisartan may be more effective than amlodipine in preventing AF recurrence in hypertensive patients with paroxysmal AF and normal or increased left atrial dimension (LAD).Methods:The authors assigned 378 mild hypertensive outpatients in sinus rhythm, but with ≥2 episodes of AF in the previous 6 months, to 1 of 2 groups. Group 1 comprised patients with LAD <40 mm in females and <45 mm in males. Group 2 comprised patients with LAD >40 mm and <45 mm in females and >45 mm and <50 mm in males. In both groups, patients were randomly treated with telmisartan or amlodipine for 1 year.Results:Systolic and diastolic blood pressure were similarly reduced by telmisartan and amlodipine in both groups. The AF recurrence rate was significantly lower in the telmisartan‐treated patients than in the amlodipine‐treated patients in both group 1 (12 vs 39, P < 0.01) and group 2 (40 vs 59, P < 0.05). Under telmisartan, the AF recurrence rate was significantly lower in group 1 than in group 2 (12.9% vs 42.1%, P < 0.05). Time to a first AF relapse was significantly longer with telmisartan than with amlodipine in both group 1 (176 ± 94 days vs 74 ± 61 days, P < 0.05) and group 2 (119 ± 65 days vs 38 ± 35 days, P < 0.05).Conclusions:Telmisartan was more effective than amlodipine in preventing AF recurrences in hypertensive patients with paroxysmal AF. Clin. Cardiol. 2012 DOI: 10.1002/clc.21994The authors have no funding, financial relationships, or conflicts of interest to disclose.
Pubertal development predicts eating behaviors in adolescence
Authors: Baker Jessica H. , Thornton Laura M. , Lichtenstein Paul , Bulik Cynthia M. 
Published: April 2012

AbstractObjective:Early maturing girls are at increased risk for disordered eating. However, it is unclear if the association between puberty and disordered eating continues throughout pubertal development and if a similar association is exhibited in boys.Method:Participants included 1340 same‐ and 624 opposite‐sex twins from the Swedish Twin Study of Child and Adolescent Development. Pubertal development was assessed at age 13–14 with the pubertal development scale. General disordered eating, measured with the eating disorder inventory‐2 (EDI) was assessed at age 16–17, and dieting and purging behaviors were assessed at both ages 16–17 and 19–20. We applied analysis of variance and logistic regression analyses to determine whether pubertal development in early‐to‐mid adolescence predicted eating disorder‐related behaviors in late adolescence and young adulthood.Results:Pubertal development in early‐to‐mid adolescence was significantly associated with EDI scores and dieting in late adolescence. No significant association was observed between pubertal development and dieting and purging in young adulthood.Discussion:Complex combinations of cultural and biological influences likely converge during pubertal development increasing vulnerability to disordered eating. The impact of pubertal development on disordered eating appears to be limited to the adolescent period. © 2012 by Wiley Periodicals, Inc. (Int J Eat Disord 2012;45:819–826)
Route guidance by a car navigation system based on augmented reality
Authors: Akaho Kengo , Nakagawa Takashi , Yamaguchi Yoshihisa , Kawai Katsuya , Kato Hirokazu , Nishida Shogo 
Published: April 2012

AbstractCar navigation systems play a prominent role in road traffic safety and traffic regulation. However, it is necessary to improve the route guidance of car navigation systems so that they accurately and quickly recognize small differences in location. Thus, to increase the ease of understanding and safety of car navigation systems, navigation systems based on augmented reality have been proposed for providing guidance at road intersections. We are currently developing a car navigation system based on augmented reality, called AR‐Navi. We investigated designs for the display of road intersection guidance that can be easily understood even when limited information is available and proposed a “best shot” display method that does not use moving images. In addition, we implemented a prototype system that includes these methods and conducted driving experiments on public roads to evaluate the ease of understanding and safety of AR‐Navi. Using the evaluation results, we confirmed that the ease of understanding and safety is similar in the case of AR‐Navi and CG‐Navi. We also clarified the characteristics of AR‐Navi. © 2012 Wiley Periodicals, Inc. Electr Eng Jpn, 180(2): 43–54, 2012; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.22278
Lanthanide‐Based Dinuclear Complexes Involving an o‐Quinone–Tetrathiafulvalene–o‐Quinone Bridging Ligand: X‐ray Structures, Magnetic and Photophysical Properties
Authors: Pointillart Fabrice , Kuropatov Viacheslav , Mitin Alexander , Maury Olivier , Le Gal Yann , Golhen Stéphane , Cador Olivier , Cherkasov Vladimir , Ouahab Lahcène 
Published: April 2012

AbstractSix dinuclear complexes, [Ln2(hfac)6(H2O)2(L)] [Ln = Y (1) and Er (2)], [Yb2(hfac)6(L)] (3), [Ln2(tta)6(L)]·3CH2Cl2 [Ln = Y (4) and Er (5)] and [Yb2(tta)6(L)]·2C6H14 (6), have been prepared by coordination reactions between the [Ln(β‐diketonate)3]·2H2O (Ln = YIII, ErIII and YbIII; β‐diketonate = hfac– or tta–) building blocks and 4,4′,7,7′‐tetra‐tert‐butyl‐2,2′‐bi‐1,3‐benzodithiole‐5,5′,6,6′‐tetrone ligand (L), which acts as a bridge between the two metal centres. Their X‐ray structures reveal that the symmetries around the lanthanide atoms depend on the β‐diketonate anions and the size of the 4f ions. The dc magnetic measurements showed paramagnetic behaviour with thermal variations of the χMT products that depend on the crystal‐field symmetry around the 4f ions. The photophysical properties of the coordination complexes were studied by solid‐state absorption spectroscopy, and DFT calculations were carried out on the free ligand L and the diamagnetic YIII derivatives 1 and 4. Irradiation of the charge‐transfer (ILCT) band of L [λex = 700 nm (14285 cm–1)], 1 and 4 [λex = 750 nm (13335 cm–1)] induced weak fluorescence in L at 12500 cm–1 (for free L) and in 1 at 12200 cm–1, whereas in the case of 3, irradiation at 13335 cm–1 induced weak line‐shape emission assigned to the 2F5/2 → 2F7/2 (9880 cm–1) ytterbium‐centred transition. No residual charge‐transfer emission was observed in this last case attesting the efficient energy transfer from the excited charge‐transfer state to the 2F5/2 state. The weak intensity of the emissions should mainly be attributed to energy back‐transfer between the relaxed CT excited state and the CT state. Nevertheless, sensitisation of the YbIII luminescence in 3 was achieved through the lowest‐energy donor excited state (13585 cm–1) reported until now.
Conformational Preference in Bis(porphyrin) Tweezer Complexes: A Versatile Chirality Sensor for α‐Chiral Carboxylic Acids
Authors: Tanasova Marina , Borhan Babak 
Published: April 2012

AbstractMetallated porphyrin tweezers have demonstrated a remarkable ability to function as reporters of absolute stereochemistry for a number of different classes of organic molecules. Flexibility in binding, however, can result in an ensemble of different Exciton Coupled Circular Dichroism (ECCD) active conformations that could lead to variable results. Linker flexibility was found to be a key determinant of binding conformation. Experimental results indicate that a balance between linker flexibility and rigidity could yield an optimum porphyrin tweezer that stabilizes a common conformation for all bound chiral guests. This leads to a more simplified approach to absolute stereochemical determination of asymmetry for small organic molecules. This was demonstrated by the use of a C3‐linked zincated porphyrin tweezer that yields a common conformational preference for a variety of α‐chiral carboxylic acids derivatized with a diamine carrier.
Voltammetry as a Reference Method in the Preparation Process of Plant Control Material Containing As, Pt and Tl
Authors: Kowalska Joanna , Giska Iwona , Jedynak Łukasz , Krasnodębska‐Ostręga Beata , Pałdyna Joanna , Sadowska Monika , Golimowski Jerzy 
Published: April 2012

AbstractVoltammetric methods are very suitable and versatile techniques for the simultaneous metal determination in complex matrices after thorough mineralization. In the presented work, voltammetric methods were used as reference methods in the preparation process of control plant material. Determination of As, Pt, Tl and other elements (Cd, Cu, Pb, Zn) in plant material prepared in our laboratory is described. For quantitative determination of the elements two independent analytical methods were applied. To obtain plant material containing As, Pt and Tl white mustard (Sinapis alba L.) was hydroponically cultivated under controlled conditions in a nutrient solution with addition of As, Pt and Tl salts.
Multiplexed Ultrasensitive Determination of Adrenocorticotropin and Cortisol Hormones at a Dual Electrochemical Immunosensor
Authors: Moreno‐Guzmán María , González‐Cortés Araceli , Yáñez‐Sedeño Paloma , Pingarrón José M. 
Published: April 2012

AbstractA novel dual electrochemical immunosensor for the multiplexed determination of adrenocorticotropin (ACTH) and cortisol is reported. Aminophenylboronic acid‐modified dual screen‐printed carbon electrodes were prepared on which the corresponding ACTH and cortisol antibodies were immobilized. Competitive immunoassays involved biotinylated ACTH and alkaline phosphatase labelled streptavidin, or alkaline phosphatase labelled cortisol. Differential pulse voltammetry upon 1‐naphtyl phosphate addition was employed to monitor the affinity reactions. The ranges of linearity were 5.0×10−5−0.1 and 0.1−500 ng/mL for ACTH and cortisol. The usefulness of the dual immunosensor was demonstrated by analyzing certified human serum samples with good recoveries.
The course of delirium in older long‐term care residents
Authors: Cole Martin G. , McCusker Jane , Voyer Philippe , Monette Johanne , Champoux Nathalie , Ciampi Antonio , Vu Minh , Belzile Eric 
Published: April 2012

ObjectiveThe purpose of this study was to determine the course of delirium in older long‐term care (LTC) residents.MethodsA prospective cohort study of 279 residents in seven LTC facilities in Montreal and Quebec City, Canada, was conducted. The Mini Mental State Examination (MMSE), Confusion Assessment Method (CAM), Delirium Index (DI), Hierarchic Dementia Scale, Barthel Index, and Cornell Scale for Depression were completed at baseline. The MMSE, CAM, and DI were repeated weekly for 6 months. Information on medical problems and medication was abstracted from resident charts. Data were analyzed using descriptive statistics, Cox proportional hazard regression, and logistic regression.ResultsOf the 279 residents, 41 (14.7%) had 61 CAM‐defined incident episodes of delirium: 28 (10%) had one episode and 13 (4.7%) had two or more episodes. Episode duration was 7–63 days, mean, 11.3 (SD, 10.1) days. The mean episode DI score was 11.5 (SD, 3.5). Rates of recovery at 1, 2, 4, and 24 weeks were 57.4%, 67.2% 77.1%, and 80.3%, respectively. Most episodes were preceded or followed by one or more CAM core symptoms of delirium, sometimes lasting many weeks.ConclusionsConfusion Assessment Method‐defined incident episodes of delirium in older LTC residents appear to last longer than episodes in acute care hospital patients, but rates of recovery at 4 and 24 weeks are similar. Notably, most episodes were preceded or followed by one or more CAM core symptoms of delirium. These findings have implications for clinical practice and research in LTC settings. Copyright © 2012 John Wiley & Sons, Ltd.
Healthcare financing in Yemen
Authors: Holst Jens , Gericke Christian A. 
Published: April 2012

SUMMARYYemen is a low‐middle‐income country where more than half of the population live in rural areas and lack access to the most basic health care. At US$40 per capita, Yemen's annual total health expenditure (THE) is among the lowest worldwide. This study analyses the preconditions and options for implementing basic social health protection in Yemen. It reveals a four‐tiered healthcare system characterised by high geographic and financial access barriers mainly for the poor. Out‐of‐pocket payments constitute 55% of THE, and cost‐sharing exemption schemes are not well organised. Resource‐allocation practices are inequitable because about 30% of THE gets spent on treatment abroad for a small number of patients, mainly from better‐off families. Against the background of a lack of social health protection, a series of small‐scale and often informal solidarity schemes have developed, and a number of public and private companies have set up health benefit schemes for their employees. Employment‐based schemes usually provide reasonable health care at an average annual cost of YR44 000 (US$200) per employee. In contrast, civil servants contribute to a mandatory health‐insurance scheme without receiving any additional health benefits in return. A number of options for initiating a pathway towards a universal health‐insurance system are discussed. Copyright © 2012 John Wiley & Sons, Ltd.
A population‐based study of human papillomavirus genotype prevalence in the United States: Baseline measures prior to mass human papillomavirus vaccination
Authors: Wheeler Cosette M. , Hunt William C. , Cuzick Jack , Langsfeld Erika , Pearse Amanda , Montoya George D. , Robertson Michael , Shearman Catherine A. , Castle Philip E. ,   For The New Mexico HPV Pap Registry Steering Committee
Published: April 2012

AbstractCurrently, two prophylactic human papillomavirus (HPV) vaccines targeting HPV 16 and 18 have been shown to be highly efficacious for preventing precursor lesions although the effectiveness of these vaccines in real‐world clinical settings must still be determined. Toward this end, an ongoing statewide surveillance program was established in New Mexico to assess all aspects of cervical cancer preventive care. Given that the reduction in cervical cancer incidence is expected to take several decades to manifest, a systematic population‐based measurement of HPV type‐specific prevalence employing an age‐ and cytology‐stratified sample of 47,617 women attending for cervical screening was conducted prior to widespread HPV vaccination. A well‐validated polymerase chain reaction (PCR) method for 37 HPV genotypes was used to test liquid‐based cytology specimens. The prevalence for any of the 37 HPV types was 27.3% overall with a maximum of 52% at age of 20 years followed by a rapid decline at older ages. The HPV 16 prevalences in women aged ≤20 years, 21–29 years or ≥30 years were 9.6, 6.5 and 1.8%, respectively. The combined prevalences of HPV 16 and 18 in these age groups were 12.0, 8.3 and 2.4%, respectively. HPV 16 and/or HPV 18 were detected in 54.5% of high‐grade squamous intraepithelial (cytologic) lesions (HSIL) and in 25.0% of those with low‐grade SIL (LSIL). These baseline data enable estimates of maximum HPV vaccine impact across time and provide critical reference measurements important to assessing clinical benefits and potential harms of HPV vaccination including increases in nonvaccine HPV types (i.e., type replacement).
SOCS‐1 gene delivery cooperates with cisplatin plus pemetrexed to exhibit preclinical antitumor activity against malignant pleural mesothelioma
Authors: Iwahori Kota , Serada Satoshi , Fujimoto Minoru , Ripley Barry , Nomura Shintaro , Mizuguchi Hiroyuki , Shimada Kazuki , Takahashi Tsuyoshi , Kawase Ichiro , Kishimoto Tadamitsu , Naka Tetsuji 
Published: April 2012

AbstractMalignant pleural mesothelioma (MPM) is an aggressive tumor with poor prognosis for which an effective therapy remains to be established. This study investigated the therapeutic potential of gene delivery using suppressor of cytokine signaling 1 (SOCS‐1), an endogenous inhibitor of intracellular signaling pathways, for the treatment of MPM. We infected MPM cells (MESO‐4, H28 and H226) with adenovirus‐expressing SOCS‐1 vector to examine the effect of SOCS‐1 overexpression on MPM cells. We evaluated the antitumor effect of SOCS‐1 gene delivery combined with cisplatin plus pemetrexed by cell proliferation, apoptosis and invasion assay. We also investigated the regulation of NF‐κB and STAT3 signaling related to apoptotic pathways. Furthermore, we evaluated the inhibition of tumor growth by SOCS‐1 gene delivery combined with cisplatin plus pemetrexed in vivo. SOCS‐1 gene delivery cooperated with cisplatin plus pemetrexed to inhibit cell proliferation, invasiveness and induction of apoptosis in MPM cells. SOCS‐1 regulated NF‐κB and STAT3 signaling to induce apoptosis in MESO‐4 and H226 cells. Furthermore, SOCS‐1 gene delivery cooperated with cisplatin plus pemetrexed to regulate NF‐κB signaling and significantly inhibit tumor growth of MPM in vivo. These results suggest that SOCS‐1 gene delivery has a potent antitumor effect against MPM and a potential for clinical use in combination with cisplatin plus pemetrexed.
Stirred flow bioreactor modulates chondrocyte growth and extracellular matrix biosynthesis in chitosan scaffolds
Authors: García Cruz Dunia Mercedes , Salmerón‐Sánchez Manuel , Gómez‐Ribelles José Luis 
Published: April 2012

AbstractThe aim of this study is to show the favorable effect of simple dynamic culture conditions on chondrogenesis of previously expanded human chondrocytes seeded in a macroporous scaffold with week cell‐pore walls adhesion. We obtained enhanced chondrogenesis by the combination of chitosan porous supports with a double micro‐ and macro‐pore structure and cell culture in a stirring bioreactor. Cell‐scaffold constructs were cultured under static or mechanically stimulated conditions using an intermittent stirred flow bioreactor during 28 days. In static culture, the chondrocytes were homogeneously distributed throughout the scaffold pores; cells adhered to the scaffold pore walls, showed extended morphology and were able to proliferate. Immunofluorescense and biochemical assays showed abundant type I collagen deposition at day 28. However, the behavior of chondrocytes submitted to mechanical stimuli in the bioreactor was completely different. Mechanical loading influenced cell morphology and extracellular matrix composition. Under dynamic conditions, chondrocytes kept their characteristic phenotype and tended to form cell aggregates surrounded by a layer of the main components of the hyaline cartilage extracellular matrix, type II collagen, and aggrecan. An enhanced aggrecan and collagen type II production was observed in engineered cartilage constructs cultured under stirred flow compared with those cultured under static conditions. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 100A: 2330–2341, 2012.
Synthesis of cationic magnetic nanoparticles and evaluation of their gene delivery efficacy in Hep G2 cells
Authors: Chen Jui‐Tse , Ahmed Marya , Liu Qingxia , Narain Ravin 
Published: April 2012

AbstractWell‐defined cationic polymers were synthesized via the reversible addition fragmentation chain transfer polymerization and were subsequently used as stabilizer for the synthesis of cationic iron‐oxide magnetic nanoparticles via the coprecipitation method. The surface‐coated iron‐oxide nanoparticles made stable suspension in water and were characterized by a range of techniques such as dynamic light scattering, transmission electron microscopy, and thermogravimetric analysis. The presence of protonated amine and carbohydrate residues onto the surface of the nanoparticles allowed their facile complexation with DNA and the resulting nanocomplexes were then studied for their efficacy as DNA carriers in Hep G2 cells. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 100A: 2342–2347, 2012.
Calculation of the relative free energy of oxidation of azurin at pH 5 and pH 9
Authors: Steiner Denise , Oostenbrink Chris , van Gunsteren Wilfred F. 
Published: April 2012

AbstractFree energy calculations are described for the small copper‐containing redox protein Azurin fromPseudomonas aeruginosa. A thermodynamic cycle connecting the reduced and oxidized states at pH 5 and pH 9 is considered, allowing for an assessment of convergence in terms of hysteresis and cycle closure. Previously published thermodynamic integration (TI) data is compared to Hamiltonian replica exchange TI (RE‐TI) simulations using different simulation setups. The effects of varying simulation length, initial structure, position restraints on particular atoms, and the strength of temperature coupling are studied. Although the overall simulation times are too short to observe an experimentally described peptide plane rotation, it is found that RE‐TI simulations do stimulate the distribution of conformational changes over the relevant values of the TI coupling parameter λ. This results in significantly improved values for hysteresis and cycle closure when compared to regular TI. © 2012 Wiley Periodicals, Inc.