bluuebunny/crossref_metadata_2025_split huggingface dataset:
Raltegravir-Based HAART Regimen in a Patient with Large B-Cell Lymphoma
Authors: Fulco Patricia Pecora , Hynicka Lauren , Rackley Dwight 
Published: December 2009

Objective:To describe the antiretroviral management of a patient diagnosed simultaneously with HIV/AIDS and diffuse large B-cell lymphoma, focusing on the drug-drug interactions between highly active antiretroviral therapy (HAART) and concomitant cancer chemotherapy.Case Summary:A 55-year-old white man was recently diagnosed with HIV/AIDS and presented 1 month later with complaints of nausea, vomiting, abdominal pain, double vision, right eye discomfort/swelling, and a 3.6-kg weight loss. An excisional biopsy of a right inguinal lymph node confirmed a new diagnosis of diffuse large B-cell lymphoma. HAART and a chemotherapeutic regimen, including cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP) with intrathecal methotrexate, was to be initiated. As the potential for multiple drug-drug interactions existed, raltegravir, abacavir, and lamivudine were chosen for the initial HAART regimen. The patient achieved and maintained an undetectable viral load throughout 6 CHOP cycles.Discussion:HAART improves the chemotherapeutic response in patients with HIV and lymphoma. Multiple drug-drug interactions are possible in patients who are to receive CHOP and HAART. Cyclophosphamide and vincristine are metabolized via the CYP3A4 isoenzyme. Protease inhibitors (Pls) and nonnucleoside reverse transcriptase inhibitors both inhibit and induce CYP3A4, with the potential for altered chemotherapeutic and cytotoxic effects. When Pls are combined with CHOP, mortality is reduced, but increased adverse effects are demonstrated. Raltegravir, an integrase inhibitor, is eliminated via glucuronidation and results in minimal drug-drug interactions. Raltegravir improves virologic and immunologic responses in HAART-naïve patients and thus would be a suitable alternative for preventing chemotherapeutic-HAART interactions.Conclusions:There is limited information published regarding the potential for interactions between HAART and cancer chemotherapy. While further research is necessary, it is important for clinicians to consider the potential for drug-drug interactions when designing a HAART regimen concurrently with chemotherapy. KEY WORDS: abacavir, antiretroviral therapy, CYP3A4, diffuse large B-cell lymphoma, drug interactions, highly active antiretroviral therapy, integrase inhibitor, lamivudine, nonnucleoside reverse transcriptase inhibitors, nucleoside reverse transcriptase inhibitors, protease inhibitors, raltegravir, tumor lysis syndrome.
Frankfurt Cases and Overdetermination
Authors: Funkhouser Eric 
Published: December 2009

For nearly forty years now, Frankfurt cases have served as one of the major contributors to the compatibilist's cause with respect to moral responsibility. These cases typically involve a causally preempted condition that is supposed to guarantee a choice without causing it. This has had the effect of softening up some to the idea that determinism does not exclude moral responsibility simply in virtue of guaranteeing a unique future. I believe that these traditional Frankfurt cases adequately support this cause. But I also believe that the traditional versions of Frankfurt cases suffer from some rhetorical defects.My strategy is as follows. First, I want to respond to a dilemma that has been raised by some libertarians against arguments utilizing Frankfurt cases. This dilemma has the effect of raising a question-begging charge against such arguments. Part of my response is to draw attention to the relevant principle that I think Frankfurt cases should really target, a principle slightly different from Harry Frankfurt's original Principle of Alternate Possibilities. Second, I elaborate and defend the claim that traditional Frankfurt cases involve causal preemption.
Propositions and Propositional Acts
Authors: Johnston D.K. 
Published: December 2009

Suppose that John asks, ‘Is the window open?’ and Mary replies, ‘The window is open.’ Then John and Mary have produced two distinct utterances, and in doing so, they have performed two different kinds of speech act. But clearly there is something that these utterances have in common. According to the standard theory of speech acts, in these utterances different illocutionary forces have been applied to the same propositional content. Similarly, if John and Mary both believe that roses are red, the same propositional content is attributed to their individual mental states.The propositional contents of utterances and beliefs have traditionally been identified with propositions. In turn, propositions have been characterized as language-independent particulars that can be re-identified in different contexts. In this article, I will argue that various phenomena that have hitherto been explained by propositions are better understood in terms of propositional acts.
Assessment of Vitamin B12 Absorption Based on the Accumulation of Orally Administered Cyanocobalamin on Transcobalamin
Authors: Hardlei Tore Forsingdal , Mørkbak Anne Louise , Bor Mustafa Vakur , Bailey Lynn B , Hvas Anne-Mette , Nexo Ebba 
Published: December 2009

AbstractBackground: Vitamin B12, or cobalamin (Cbl), is absorbed in the intestine and transported to the cells bound to transcobalamin (TC). We hypothesize that cyanocobalamin (CNCbl) is absorbed unchanged, thereby allowing measurement of the complex of CNCbl bound to TC (TC–CNCbl) to be used for studying the absorption of the vitamin.Methods: TC was immunoprecipitated from serum samples obtained from healthy donors at baseline and at 24 h after oral administration of three 9-μg CNCbl doses over 1 day. Cbl was released by treatment with subtilisin Carlsberg. The different forms of Cbl were isolated by HPLC and subsequently quantified with an ELISA-based Cbl assay.Results: At baseline, the median TC–CNCbl concentration was 1 pmol/L (range, 0–10 pmol/L); the intraindividual variation (SD) was 1.6 pmol/L (n = 31). After CNCbl administration, the TC–CNCbl concentration increased significantly (P = 0.0003, paired t-test), whereas no major changes were observed in any of the other Cbl forms bound to TC (n = 10). Only a moderate additional increase in TC–CNCbl was observed with prolonged (5 days) CNCbl administration (n = 10). We designed an absorption test based on measuring TC–CNCbl at baseline and 24 h after CNCbl intake and established a reference interval for the increase in TC–CNCbl (n = 78). The median absolute increase was 23 pmol/L (range, 6–64 pmol/L), and the relative increase was &gt;3-fold.Conclusions: Our data demonstrate that CNCbl is absorbed unchanged and accumulates on circulating TC. We suggest that measuring TC–CNCbl will improve the assessment of vitamin B12 absorption.
Detection of Drug-Resistant Clones in Chronic Myelogenous Leukemia Patients during Dasatinib and Nilotinib Treatment
Authors: Gruber Franz X , Ernst Thomas , Kiselev Yuri , Hochhaus Andreas , Mikkola Ingvild 
Published: December 2009

AbstractBackground: Imatinib effectively inhibits the tyrosine kinase activity conferred by the BCR-ABL gene [fusion gene of BCR (breakpoint cluster region) and ABL1 (c-abl oncogene 1, receptor tyrosine kinase)] and thereby appreciably improves outcomes for chronic myelogenous leukemia (CML). A small percentage of patients relapse because of the proliferation of escape clones; such relapses can be treated with second-generation drugs. Early detection and monitoring of resistant clones may provide clinical benefit. We describe the development and testing of a new approach for quantitative monitoring of CML resistance.Methods: We designed mutation-specific assays that use hydrolysis probes and an array of allele-specific primers containing nucleotides mismatched at various positions. All assays were tested with plasmids containing corresponding mutant or wild-type sequences, allowing identification of optimal assays for specific and effective amplification of the target template. Clinical samples were then used to compare the results of selected assays with those of standard genotyping.Results: We used a modified amplification refractory mutational system approach and testing with plasmid constructs to design assays that allowed highly selective detection of resistance for all target mutations. By taking advantage of single-step performance and high PCR efficiency, we were able to quantitatively track the absolute amount of resistance conferred by a specific mutation over 4 orders of magnitude. Moreover, we designed an integrated test for dasatinib resistance that uses multiple primers simultaneously.Conclusions: These single-step, closed-tube assays specifically target mutations associated with resistance to dasatinib or nilotinib. Compared with standard genotyping, such biased genotyping improves the detection of resistance or alternative features via quantitative analysis of the absolute amount of resistance.
Reliability of InP-based HBTs at High Current Density
Authors: Fukai Yoshino 
Published: January 2010

AbstractInP-based HBTs for ultrahigh speed optical communications systems operation at over 40 GHz require a long-term stability under high current injection conditions, such as current densities of 2 or 5 mA/μm2. We achieved high reliability by suppressing surface recombination and emitter-metal-related crystalline degradation.Changes in the electric properties of devices due to temperature and bias stress were evaluated. The reduction in DC current gain due to surface recombination had the activation energy of 1.7 eV without current density dependence, and the lifetime of HBTs for this degradation mode is predicted to be over 1×108 hours at 125°C. The emitter metal diffusion and disruption of uniformity of the atomic composition were observed by transmission electron microscopy and energy dispersive X-ray spectroscopy in HBTs with the conventional Ti/Pt/Au emitter, whereas suppression of those degradations was observed in HBTs with refractory metal of Mo and W. The emitter resistance was estimated to evaluate the contact layer degradation. The critical time was one order larger for HBTs with refractory metal than for HBTs with conventional metal. The activation energies for resistance increases were 2.0 and 1.65 eV for the current density of 2 and 5 mA/μm2, respectively, for all types of emitter electrodes.The effectiveness of the refractory metal electrode for improving device reliability was confirmed, especially in high-current-density operation, which is essential for applying InP HBTs in high-speed ICs.
Influences of Polarization Effects in the Electrical Properties of Polycrystalline MgZnO/ZnO Heterostructure
Authors: Chin Huai-An , Huang Chih-I , Wu Yuh-Renn , Cheng I-Chun , Chen Jian Z. , Chiu Kuo-Chuang , Lin Tzer-Shen 
Published: January 2010

AbstractZnO has shown great promise for the application in optoelectronic devices. Since the modulation of conductivity is one of the key issues in device performances, we have applied the Monte Carlo method to analyze the mobility of poly-crystalline MgZnO/ZnO heterostructure thin film layer in this paper. The effects of the grain boundary scattering, ionized impurity scattering, as well as phonon scattering are considered. Our study shows that with a design of modulation doping by including the effects of spontaneous and piezoelectric polarization, the grain boundary potential can be suppressed to improve the mobility of the ZnO layer by order(s) of magnitude. Simulation results are also confirmed by our experimental works that polarization effects play an important role to attract carriers and to increase the mobility.
A Luminescence Study of Electron-Irradiated ZnO Crystals
Authors: Avella Manuel , Martínez Oscar , Jiménez Juan , Wang Buguo , Devrinsky P. , Bliss David 
Published: January 2010

AbstractZnO crystals were irradiated with high energy electrons (1MeV). The main defects created were analyzed by cathodoluminescence (CL) spectroscopy. The main effects of irradiation on the CL spectrum were the partial quenching of the emission, the shift of the visible luminescence to the yellow, and the observation of an additional band and its phonon replicas at ∼3.32 eV. Zinc vacancy related defects are postulated as responsible for the changes induced in the spectrum.
Photocurrent measurements of MgxZn1-xO epitaxial layers of different x
Authors: Thöt Richard K. , Sander Thomas , Klar Peter J. , Meyer Bruno 
Published: January 2010

AbstractThe MgxZn1-xO alloy in wurtzite structure can be grown with Mg contents x up to 0.4. The band gap of the alloy increases with x. Furthermore, ZnO/MgxZn1-xO quantum well structures are of type I and thus are of interest for the active region of opto-electronic devices.We report on in-plane photocurrent measurements of MgxZn1-xO epitaxial layers with x up to about 0.4 in the temperature range from 80 K to 300 K. Epitaxial films are either grown by plasma-assisted molecular beam epitaxy on c-plane sapphire substrates with a thin MgZnO buffer layer and by chemical vapor deposition on a-plane ZnO substrates. We map the evolution of the band gap transitions as a function of the Mg composition at different temperatures for the c-plane samples and as a function of polarization of the incoming light for an a-plane sample. The contributions of A, B and C interband transitions to the band gap signals are analysed and discussed.
Measuring the Young’s Relaxation Modulus of PDMS Using Stress Relaxation Nanoindentation
Authors: Du Ping , Lu Hongbing , Zhang Xin 
Published: January 2010

AbstractThe Young’s relaxation modulus of Polydimethylsiloxane (PDMS) film specimens was measured by the nanoindenter with a flat punch indenter. In the stress relaxation test, the initial ramp part was carefully considered to develop an accurate viscoelastic contact model. This model was used to fit the load-time data from the experimental tests. The resulting relaxation function was expressed by a general Maxwell equation. In addition, a case study of PDMS micropillar bending tests was performed, and the viscoelastic constitutive law was applied to develop an analytical solution of the reaction force. The results show that the reaction force calculated from the corrected model is generally agreed well with the experimental data.
Magnesium-based Biodegradable Nanostructured Substrates: Hybrid Materials for Cellular Engraftment
Authors: Schoen Tobias , Wolfram Tobias , Spatz Joachim P 
Published: January 2010

AbstractMagnesium and its alloys are used as implants because of their biocompatibility and high strength-to-weight ratio. In contrast to other commonly used implantable materials such as stainless steel and Co-Cr-alloys, which may release toxic metallic ions, magnesium belongs to the natural composition of the human body. Our work is focused on engineering a cellular carrier system based on biodegradable magnesium and magnesium alloy substrates, which are decorated with gold nanoparticles to form magnesium-gold (Mg-Au) hybrid materials. Specifically, we deposited gold nanoparticles on MgO single crystals (100 orientation) and on AZ31-Mg alloy substrates using diblock copolymer micelle nanolithography. The gold nanoparticles were arranged in ordered arrays with controllable interparticle distances of 25 to 300 nm and were further functionalized with RGD-thiols or fibronectin. This method allowed the deposition of a protein carpet on top of the surface and facilitated the initial adhesion of cells on the magnesium substrates. In order to determine the stability of the substrates in a physiological environment, their corrosive behavior was studied by comparing the weight of the substrates before and after a 24h-long submersion in water, PBS, or cell culture medium and by studying the post-submersion surface morphology with scanning electron microscopy. Corrosion rates of magnesium substrates in PBS and cell culture medium were significantly higher than in water. The spreading and survival of C2C12 mouse myoblasts and human mesenchymal stem cells cultured on MgO single crystals and AZ31-alloys were investigated with fluorescence and phase contrast microscopy. The spreading and survival of C2C12 myoblasts on the Mg-Au hybrid materials were different than on non-functionalized Mg substrates. Additionally, cells on non-functionalized MgO crystals showed reduced filopodia activity. Our results show that biofunctionalized and engineered magnesium-based substrates can be used as carriers for different cellular systems and promising initial steps have been taken towards an implantable device with a defined biological surface activity made from magnesium materials.
The Use of Electrospun Polycaprolactone as a Dermal Scaffold for Skin Tissue Engineering
Authors: Chen Ming , Chopra Manisha , Bhowmick Sankha 
Published: January 2010

AbstractRapid healing of acute and chronic skin defects is an important objective. In the present work, we report on the design and feasibility of a co-culture system for fibroblasts and keratinocytes by using electrospun polycaprolactone (PCL) scaffolds. Specifically, we quantified the effect of scaffold fiber diameter on keratinocyte attachment, proliferation and differentiation along with collagen secretion by fibroblasts post vacuum seeding with fibroblasts at various depths. The results show that fibroblasts secrete more collagen and keratinocytes differentiate more on 400 nm scaffolds than on 1000 nm scaffolds. Also, fibroblasts co-cultured with keratinocytes provide increased collagen secretion and keratinocyte differentiation. These results suggest that the fiber architecture can be a useful parameter in skin tissue engineering.
Suture zones and importance of strike-slip faulting for Variscan geodynamic reconstructions of the External Crystalline Massifs of the western Alps
Authors: Guillot Stéphane , di Paola Silvia , Ménot René-Pierre , Ledru Patrick , Spalla Maria Iole , Gosso Guido , Schwartz Stéphane 
Published: December 2009

AbstractThis paper reviews the geodynamic evolution of the Belledonne, Grandes Rousses and Oisans massifs in the western Alps from Early Ordovician to Permian times. Three domains are distinguished. The eastern domain, which includes the NE Belledonne massif and the inner Oisans massif, records the subduction of the Central-European ocean along a NW dipping subduction zone. The western domain is marked by Cambro-Ordovician back-arc rifting (Chamrousse ophiolite) initiating the opening of the Rheic ocean. It was followed by Mid-Devonian obduction of the back-arc Chamrousse ophiolite, towards the NW in relation with the SE dipping subduction of the Saxo-Thuringian ocean. The central domain, including the SW part of the Belledonne massif, the Grandes Rousses massif and the outer Oisans massif, records the Devonian to Carboniferous orogenic activity that produced calc-alkaline magmatism, Mg-K granite intrusions and syn-collisional sedimentation related to Visean nappe stacking that we relate to the closure of the Saxo-Thuringian ocean. Based on tectonostratigraphic correlations we propose that these domains initially correspond to the northeastward extension of the Bohemian massif. During the late Carboniferous, the External Crystalline Massifs including Sardinia and Corsica were stretched towards the SW along the &gt; 600 km long dextral External Crystalline Massifs shear zone. Offset of the Saxo-Thuringian and eo-Variscan suture zones from the Bohemian massif to the ECM suggests a possible dextral displacement of about 300 km along the ECM shear zone.
Variscan structure in the eastern part of the Pallaresa massif, Axial Zone of the Pyrenees (NW Andorra). Tectonic implications
Authors: Clariana Pilar , García-sansegundo Joaquin 
Published: December 2009

AbstractThe Variscan structures of the Axial Zone of the Pyrenees are traditionally separated into the “infrastructure” and the “suprastructure” domains. Three deformation events have been recognized within Cambro-Ordovician rocks in the eastern part of the Pallaresa massif. D1 consists of a slaty cleavage (S1), and no folds have been found associated with it. The D2 event is characterized by E-W trending and north-verging recumbent folds with an associated foliation (S2) that can be observed at all scales. The S2 foliation has a horizontal orientation, and is the main foliation in the northern and central parts of the study area. The D3 deformation event is distinguished by development of E-W trending, upright folds, of centimetric to metric scale. These folds are associated with a steep and rough crenulation cleavage (S3) in the southern part of the study area. Subvertical faults trending E-W are associated with D3 folds. Most of the structures recognized in the eastern part of the Pallaresa massif have developed under low metamorphic grade conditions, although close to the Aston and Hospitalet domes, in the vicinity of some igneous intrusions, the metamorphism is coeval with S2 foliation and may reach high grade conditions. A gradual transition can be observed from zones characterized by structures of type D2 to zones exhibiting a better development of D3 structures. This transition can be explained by a décollement level located in the Cambro-Ordovician succession. This level can be related to faults and D3 folds observed in the eastern part of the Pallaresa massif. Most of the structures can be explained in a contractional geological setting. In addition the relationships between the different Variscan structures of the eastern part of the Pallaresa massif are better described. The different models recently presented by some authors about the Variscan structure of the Pyrenees are discussed in the light of these new results.
Visean sinistral wrench faulting along the Sillon Houiller in the French Massif Central: Late Variscan tectonic implications
Authors: Thiery Vincent , Rolin Patrick , Marquer Didier , Cocherie Alain , Fanning C. Mark , Rossi Philippe 
Published: December 2009

AbstractThe Sillon Houiller is one of the main crustal discontinuities of the Variscan domain of the French Massif Central. Paradoxically, its kinematics and its tectonic significance are still a matter of debate.Since Grolier and Letourneur [1968]’s works, a Stephanian sinistral offset, inferred from the emplacement of numerous coal basins along the fault, is widely accepted.The earlier history of this accident is still debated and subject to controversies. The finite offset of the Sillon Houiller results from the superposition of 3 distinct events. The first one is a brittle/ductile accident that is probably at the origin of the main left-lateral motion. Dated granitoid intrusions and Visean tuff basins seal this accident. The later Stephanian motion is revealed by brittle faulting related to coal basin opening. Finally, a vertical offset of the fault is suggested by a few strong-dipping striations.The Visean offset of the Sillon Houiller has first order implications for the understanding of the western Europe Variscan orogeny. We suggest that the Sillon Houiller and the Paris Basin Magnetic anomaly belong to a single crustal discontinuity interpreted as the eastern boundary of the Armorican/Massif Central block. The 15° clockwise rotation affecting this crustal block and inferred from the structural study of this domain occurred along this accident. The magnetic and gravimetric anomaly may be the result of Visean mafic intrusions, such as quartz diorites that are exposed in the northern part of the Massif Central close to the southern end of the anomaly.