bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH GAYA KEPEMIMPINAN DAN KOMUNIKASI ORGANISASI TERHADAP KINERJA GURU SD, SMP DAN SMK PUTRA PERTIWI PONDOK CABE, TANGERANG SELATAN
Authors: Fauziah Gina , Suri Atika , Yopi Muhamad 
Published: June 2024

ABSTRAK
Tujuan penelitian ini adalah untuk mengetahui pengaruh gaya kepemimpinan dan komunikasi organasisa terjadap kinerja guru SD, SMP dan SMK Putra Pertiwi Pondok Cabe, Tangerang Selatan. Metode yang digunakan adalah kuantitatif. Teknik pengambilan sampel menggunakan sampling jenuh, dimana semua populasi dipakai sebagai sampel dalam penelitian ini berjumlah 33 responden. Analisis data menggunakan uji validitas, uji reliabilitas, uji asumsi klasik, analisis regresi, analisis koefisien korelasi, analisis koefisien determinasi, dan uji hipotesis. Hasil penelitian ini menunjukan Variabel (X1) Gaya kepemimpinan berpengaruh signifikan secara parsial terhadap variabel (Y) Kinerja karyawan dengan nilai koefisien regresi 0,571. Variabel (X2) Komunikasi berpengaruh signifikan secara parsial terhadap variabel (Y) Kinerja karyawan dengan nilai Koefisien sebesar 0,364, dan Variabel (X1) Gaya kepemimpinan dan Variabel (X2) Komunikasi secara bersama-sama memiliki pengaruh signifikan terhadap Variebel (Y) Kinerja karyawan dengan nilai koefisien determinasi sebesar 83,1%, sedangkan sisanya sebesar 16,9% merupakan kontribusi variabel lain selain Kepemimpinan dan Komunikasi.

Kata Kunci : Gaya Kepemimpinan; Komunikasi; Kinerja Guru

THE INFLUENCE OF LEADERSHIP STYLE AND ORGANIZATIONAL COMMUNICATION ON THE PERFORMANCE OF PRIMARY, SMP AND VOCATIONAL TEACHERS IN PUTRA PERTIWI PONDOK CABE, SELATAN TANGERANG

ABSTRACT
The aim of this research is to determine the influence of leadership style and organizational communication on the performance of elementary, middle school and vocational school teachers at Putra Pertiwi Pondok Cabe, South Tangerang. The method used is quantitative. The sampling technique used saturated sampling, where the entire population was used as a sample in this study totaling 33 respondents. Data analysis uses validity tests, reliability tests, classical assumption tests, regression analysis, correlation coefficient analysis, coefficient of determination analysis, and hypothesis testing. The results of this research show that the variable (X1) leadership style has a partially significant effect on the variable (Y) employee performance with a regression coefficient value of 0.571. Variable (X2) Communication has a partially significant effect on variable (Y) Employee performance with a coefficient value of 0.364, and Variable (X1) Leadership style and Variable (X2) Communication together have a significant influence on Variable (Y) Employee performance with The coefficient of determination value is 83.1%, while the remaining 16.9% is the contribution of other variables besides Leadership and Communication
Keywords:; Leadership Style; Communication; Teacher Performance
Effect of training with the gradual distance drill method on the shooting skills of pétanque players
Authors: Mirop Dominggus , Satria M. Haris 
Published: June 2024

Shooting ability in petanque sports is an important aspect that affects the performance of athletes. The phased distance drill method is very effective in improving skills in various sports areas. The problem lies in the effectiveness of the gradual distance drill training model to enhance the shooting ability of petanque athletes in the Tebedak petanque Club. The research method used an experimental approach one group pretest-posttest Design. The experiment will last about 6 weeks at a frequency of 3 workouts a week. The sample totaled 12 athletes. Inturmen research using test Shooting Game station 1 to station 5 with distance increments of 6,7,8, and 9 meters. Data were collected through direct observation of athletes ' training before and after training. Data analysis using SPSS version 23 to measure pretest and posttest. The results showed a significant effect of gradual distance drill method training on improving the shooting ability of petanque athletes in Tebedak petanque Club. Training summary the gradual distance drill method is very effective in improving the shooting ability of petanque athletes. The next research can pay attention to the drill training model to design a petanque athlete training program in other clubs.
The influence and mechanism exploration of hydration environment on the stability of natural clay crude oil emulsion
Authors: Zhang Shusong , Liu Tianyu , Chen Qingyuan , Xiao Bao , Xian Xiaokang , Ye Zhongbin 
Published: June 2024

The study investigated the effects and mechanisms of clay content, emulsion water content, pH, and metal cations on clay-crude oil emulsions. The results indicate the following: 1) At a water content of 50 V/V%, montmorillonite can form emulsions with crude oil at different concentrations, with the highest stability observed at 5 wt% content. In contrast, chlorite, illite, and kaolinite cannot form emulsions at low concentrations. 2) Under acidic conditions, montmorillonite, illite, and chlorite cannot form emulsions with crude oil, or the emulsions are highly unstable. However, kaolinite forms more stable emulsions under acidic conditions. In alkaline environments, emulsions formed by all clay minerals exhibit increased stability. 3) The order of the effectiveness of different metal cations in reducing the stability of montmorillonite-crude oil emulsions is K+ &gt; Na+ &gt; Mg2+ &gt; Ca2+, while for chlorite, illite, and kaolinite, it is Mg2+ &gt; Ca2+ &gt; K+ &gt; Na+. 4) The factors that influence the stability of clay-crude oil emulsions are the arrangement of clay particles in water and the dispersion capability of clay particles in water. The most significant influencing factor is the arrangement of clay particles in water.
Drone-based early detection of bark beetle infested spruce trees differs in endemic and epidemic populations
Authors: Bozzini Aurora , Brugnaro Stefano , Morgante Giuseppe , Santoiemma Giacomo , Deganutti Luca , Finozzi Valerio , Battisti Andrea , Faccoli Massimo 
Published: June 2024

IntroductionEuropean forests face increasing threats due to climate change-induced stressors, which create the perfect conditions for bark beetle outbreaks. The most important spruce forest pest in Europe is the European Spruce Bark Beetle (Ips typographus L.). Effective management of I. typographus outbreaks necessitates the timely detection of recently attacked spruce trees, which is challenging given the difficulty in spotting symptoms on infested tree crowns. Bark beetle population density is one of many factors that can affect infestation rate and symptoms development. This study compares the appearance of early symptoms in endemic and epidemic bark beetle populations using highresolution Unmanned Aerial Vehicles (UAV) multispectral imagery.MethodsIn spring of 2022, host colonization by bark beetles was induced on groups of spruce trees growing in 10 sites in the Southern Alps, characterized by different population density (5 epidemic and 5 endemic). A multispectral sensor mounted on a drone captured images once every 2 weeks, from May to August 2022. The analyses of a set of vegetational indices allowed the actual infested trees’ reflectance features and symptoms appearance to be observed at each site, comparing them with those of unattacked trees.ResultsResults show that high bark beetles population density triggers a more rapid and intense response regarding the emergence of symptoms. Infested trees were detected at least 1 month before symptoms became evident to the human eye (red phase) in epidemic sites, while this was not possible in endemic sites. Key performing vegetation indices included NDVI (Normalized Difference Vegetation Index), SAVI (Soil Adjust Vegetation Index, with a correction factor of 0.44), and NDRE (Normalized Difference Red Edge index).DiscussionThis early-detection approach could allow automatic diagnosis of bark beetles’ infestations and provide useful guidance for the management of areas suffering pest outbreaks.
Clinical profiles and molecular genetic analyses of 98 Chinese children with short statures
Authors: Fang Danfeng , Li Xing , Zhang Zhigang , Cai Hefei , Wang Lu , Yu Jiahe , Hu Xuanye , Ye Bin 
Published: June 2024

BackgroundShort stature is one of the most prevalent endocrine disorders in children, and its genetic basis is a complex and actively researched subject. Currently, there is limited genetic research on exome sequencing for short stature, and more large-scale studies are necessary for further exploration.MethodsThe retrospective study entailed investigation of 98 Chinese children with short statures (height SDS ≤ −2.5) of unknown etiologies recruited between 2017 and 2021. Whole-exome sequencing (WES) was performed on these patients to identify the potential genetic etiologies. The clinical data were reviewed retrospectively to assess the pathogenicity of the identified mutations. Additionally, 31 patients consented to and received recombinant human growth hormone (rhGH) therapy for 12 months. The short-term effects of rhGH treatment were evaluated across different etiologies of patients with short statures.ResultsThe WES results were used to identify 31 different variants in 18 genes among 24 (24.5%) patients. Individuals with more severe short statures were more likely to have underlying genetic etiologies. Short stature accompanied by other phenotypes had significantly higher diagnostic yields than simple severe short stature. The rhGH therapy demonstrated efficacy in most children. Nevertheless, the treatment response was suboptimal in a boy diagnosed with 3M syndrome.ConclusionWES is an important approach for confirming genetic disorders in patients with severe short statures of unknown etiologies, suggesting that it could be used as a primary diagnostic strategy. The administration of rhGH may not be suitable for all children with short statures, and the identification of the genetic cause of short stature by WES has significant guidance value for rhGH treatment.
Effectiveness of PD-1 inhibitor-based first-line therapy in Chinese patients with metastatic gastric cancer: a retrospective real-world study
Authors: Duan Yichun , Li Jielang , Zhou Shuang , Bi Feng 
Published: June 2024

ObjectiveProgrammed cell death protein-1 (PD-1) inhibitor-based therapy has demonstrated promising results in metastatic gastric cancer (MGC). However, the previous researches are mostly clinical trials and have reached various conclusions. Our objective is to investigate the efficacy of PD-1 inhibitor-based treatment as first-line therapy for MGC, utilizing real-world data from China, and further analyze predictive biomarkers for efficacy.MethodsThis retrospective study comprised 105 patients diagnosed with MGC who underwent various PD-1 inhibitor-based treatments as first-line therapy at West China Hospital of Sichuan University from January 2018 to December 2022. Patient characteristics, treatment regimens, and tumor responses were extracted. We also conducted univariate and multivariate analyses to assess the relationship between clinical features and treatment outcomes. Additionally, we evaluated the predictive efficacy of several commonly used biomarkers for PD-1 inhibitor treatments.ResultsOverall, after 28.0 months of follow-up among the 105 patients included in our study, the objective response rate (ORR) was 30.5%, and the disease control rate (DCR) was 89.5% post-treatment, with two individuals (1.9%) achieving complete response (CR). The median progression-free survival (mPFS) was 9.0 months, and the median overall survival (mOS) was 22.0 months. According to both univariate and multivariate analyses, favorable OS was associated with patients having Eastern Cooperative Oncology Group performance status (ECOG PS) of 0–1. Additionally, normal baseline levels of carcinoembryonic antigen (CEA), as well as the combination of PD-1 inhibitors with chemotherapy and trastuzumab in patients with human epidermal growth factor receptor 2 (HER2)-positive MGC, independently predicted longer PFS and OS. However, microsatellite instability/mismatch repair (MSI/MMR) status and Epstein-Barr virus (EBV) infection status were not significantly correlated with PFS or OS extension.ConclusionAs the first-line treatment, PD-1 inhibitors, either as monotherapy or in combination therapy, are promising to prolong survival for patients with metastatic gastric cancer. Additionally, baseline level of CEA is a potential predictive biomarker for identifying patients mostly responsive to PD-1 inhibitors.
Identification of drug targets for Sjögren’s syndrome: multi-omics Mendelian randomization and colocalization analyses
Authors: Bai Yingjie , Wang Jiayi , Feng Xuefeng , Xie Le , Qin Shengao , Ma Guowu , Zhang Fan 
Published: June 2024

BackgroundTargeted therapy for Sjögren’s syndrome (SS) has become an important focus for clinicians. Multi-omics-wide Mendelian randomization (MR) analyses have provided new ideas for identifying potential drug targets.MethodsWe conducted summary-data-based Mendelian randomization (SMR) analysis to evaluate therapeutic targets associated with SS by integrating DNA methylation, gene expression and protein quantitative trait loci (mQTL, eQTL, and pQTL, respectively). Genetic associations with SS were derived from the FinnGen study (discovery) and the GWAS catalog (replication). Colocalization analyses were employed to determine whether two potentially relevant phenotypes share the same genetic factors in a given region. Moreover, to delve deeper into potential regulation among DNA methylation, gene expression, and protein abundance, we conducted MR analysis to explore the causal relationship between candidate gene methylation and expression, as well as between gene expression and protein abundance. Drug prediction and molecular docking were further employed to validate the pharmacological activity of the candidate drug targets.ResultsUpon integrating the multi-omics data, we identified three genes associated with SS risk: TNFAIP3, BTN3A1, and PLAU. The methylation of cg22068371 in BTN3A1 was positively associated with protein levels, consistent with the negative effect of cg22068371 methylation on the risk of SS. Additionally, positive correlations were observed between the gene methylation of PLAU (cg04939496) and expression, as well as between expression and protein levels. This consistency elucidates the promotional effects of PLAU on SS risk at the DNA methylation, gene expression, and protein levels. At the protein level, genetically predicted TNFAIP3 (OR 2.47, 95% CI 1.56–3.92) was positively associated with SS risk, while BTN3A1 (OR 2.96E-03, 95% CI 2.63E-04–3.33E-02) was negatively associated with SS risk. Molecular docking showed stable binding for candidate drugs and target proteins.ConclusionOur study reveals promising therapeutic targets for the treatment of SS, providing valuable insights into targeted therapy for SS. However, further validation through future experiments is warranted.
Interruption of anti-thymocyte globuline treatment in solid organ transplantation is effectively monitored through a low total lymphocyte count
Authors: Rasander Rikke Olund , Sørensen Søren Schwartz , Krohn Paul Suno , Bruunsgaard Helle 
Published: June 2024

IntroductionAnti-Thymocyte Globulin (ATG) is a cornerstone in immune suppression for solid organ transplantation. The treatment is a delicate balance between complications arising from over-immunosuppression such as infections and cancer versus rejection stemming from under-immunosuppression. CD3+ T-lymphocyte measurements are frequently employed for treatment monitoring. However, this analysis is costly and not always accessible. The aim of this study was to investigate whether the total count of lymphocytes could replace CD3+ T-lymphocyte measurements based on data from our transplantation center combined with a review of the literature. The hypothesis was that the total lymphocyte count could serve as a diagnostic surrogate marker for CD3+ T-lymphocytes.MethodsA retrospective cohort study was conducted, including patients who underwent kidney and/or a pancreas transplantation and received ATG as induction therapy or for rejection treatment. The inclusion criterium was that the total lymphocyte count and CD3+ T-lymphocyte measurements were measured simultaneously on the same day. Additionally, PubMed and Embase were searched up to 18/10/2023 for published studies on solid organ transplantation, ATG, T-lymphocytes, lymphocyte count, and monitoring. In the retrospective cohort study, a total of 91 patients transplanted between 2016 and 2023, with 487 samples, were included. ResultsTotal lymphocyte counts below 0.3 x 109/L had a high sensitivity (86%) as a surrogate marker of CD3+ T-lymphocytes below 0.05 x 109/L, but the specificity was low (52%) for total lymphocyte counts above 0.3 x 109/L as a surrogate marker for CD3+ T-lymphocytes above 0.05 x 109/L. A review of the literature identified seven studies comparing total lymphocyte counts and CD3+ T-lymphocytes in ATG monitoring. These studies supported the use of a low total lymphocyte count as a surrogate marker for CD3+ T-lymphocytes and an indicator to omit ATG treatment. However, there was no consensus regarding high total lymphocyte counts as an indicator for continued treatment.DiscussionResults supports that the total lymphocyte count can be used to omit ATG treatment when below 0.3 x 109/L whereas the CD3+ T-lymphocyte analysis should be reserved for higher total lymphocyte counts to avoid ATG overtreatment.
The complement regulatory protein CD46 serves as a novel biomarker for cervical cancer diagnosis and prognosis evaluation
Authors: Yu Jun-Hui , Yuan Hao-Bo , Yan Zi-Yi , Zhang Xia , Xu Hui-Hui 
Published: June 2024

BackgroundCD46 has been revealed to be a key factor in malignant transformation and cancer treatment. However, the clinical significance of CD46 in cervical cancer remains unclear, and this study aimed to evaluate its role in cervical cancer diagnosis and prognosis evaluation.MethodsA total of 180 patients with an initial diagnosis of cervical cancer were enrolled at Taizhou Hospital of Zhejiang Province, China. The plasma levels of soluble CD46 (sCD46) and the expression of membrane-bound CD46 (mCD46) were detected by enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry (IHC), respectively.ResultsCD46 was found to be significantly upregulated in cervical cancer tissues vs. normal tissues, while no CD46 staining was detected in paired adjacent noncancerous tissues. CD46 staining was more pronounced in cancer cells than in stromal cells in situ (in tissues). Moreover, the plasma levels of sCD46 were able to some extent discriminate between cancer patients and healthy women (AUC=0.6847, 95% CI:0.6152–0.7541). Analysis of Kaplan–Meier survival curves revealed that patients with low CD46 expression had slightly longer overall survival (OS) than patients with high CD46 expression in the tumor microenvironment, but no significant difference. Univariate Cox regression analysis revealed that CD46 (P=0.034) is an independent risk factor for OS in cervical cancer patients.ConclusionThe present study demonstrated that cervical cancer patients exhibit aberrant expression of CD46, which is closely associated with a poor prognosis, suggesting that CD46 plays a key role in promoting cervical carcinogenesis and that CD46 could serve as a promising potential target for precision therapy for cervical cancer.
Divergent assembly of soil microbial necromass from microbial and organic fertilizers in Chimonobambusa hejiangensis forest
Authors: Cai Xue , Long Zhijian , Li Yongyang , Cao Ying , Wang Boya , Zhao Bo , Ren Peng , Zhao Xin , Huang Yan , Lu Xueqin , Hu Shanglian , Xu Gang 
Published: June 2024

IntroductionVariability in microbial residues within soil aggregates are becoming progressively essential to the nutritive and sustainability of soils, and are therefore broadly regarded as an indispensable part of soil organic matter. It is unexplored how the widespread implementation of microbial fertilisers in agricultural production impacts soil organic nutrients, in particular the microbial residue fraction.MethodsWe performed a three-year field experiment to verify the distinct impacts of microbial and organic fertilizers on carbon accumulation in soil microbial leftovers among aggregate fractions.ResultsMicrobial residual carbon was shown to decrease insignificantly during the application of microbial fertilizer and to rise marginally afterwards with the utilization of organic fertilizer. However, the combined effects of the two fertilizers had substantial impacts on the accumulation of microbial residual carbon. Changes in the structure of the fungi and bacteria shown in this study have implications for the short-term potential of microbial fertilizer shortages to permanent soil carbon sequestration. Additionally, our findings revealed variations in microbial residue accumulation across the microbial fertilizers, with Azotobacter chroococcum fertilizer being preferable to Bacillus mucilaginosus fertilizer due to its higher efficiency. In this scenario of nutrient addition, fungal residues may serve as the primary binding component or focal point for the production of new microaggregates, since the quantity of SOC provided by fungal residues increased while that supplied by bacterial residues decreased.DiscussionOur findings collectively suggested that the mechanisms behind the observed bacterial and fungal MRC (microbial residue carbon) responses to microbial fertilizer or organic fertilizer in bamboo forest soils are likely to be distinct. The application of microbial fertilizers for a limited duration led to a decline soil stable carbon pool, potentially influencing the regulation of soil nutrients in such hilly bamboo forests.