bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility, Clinical Potential, and Limitations of Trans-Burr Hole Ultrasound for Postoperative Evaluation of Chronic Subdural Hematoma: A Prospective Pilot Study
Authors: Aspalter Stefan , Gmeiner Matthias , Gasser Stefan , Sonnberger Michael , Stroh Nico , Rauch Philip , Gruber Andreas , Stefanits Harald 
Published: April 2024

BACKGROUND AND OBJECTIVES:
Chronic subdural hematoma (CSDH) is commonly managed through burr hole surgery. Routine follow-up using computed tomography (CT) imaging is frequently used at many institutions, contributing to significant radiation exposure. This study evaluates the feasibility, safety, and reliability of trans-burr hole sonography as an alternative postoperative imaging modality, aiming to reduce radiation exposure by decreasing the frequency of CT scans.

METHODS:
We conducted a prospective pilot study on 20 patients who underwent burr hole surgery for CSDH. Postoperative imaging included both CT and sonographic examinations through the burr hole. We assessed the ability to measure residual subdural fluid thickness under the burr hole sonographically compared with CT, the occurrence of complications, and the potential factors affecting sonographic image quality. The Pearson correlation coefficient was used to demonstrate relationships between CT and ultrasound and axial and coronal ultrasound.

RESULTS:
Sonography through the burr hole was feasible in 73.5% of cases, providing measurements of residual fluid that closely paralleled CT findings, with an average discrepancy of 1.2 mm for axial and 1.4 mm for coronal sonographic views. A strong positive correlation was found between axial and coronal ultrasound (r = 0.955), CT and axial ultrasound (r = 0.936), and CT and coronal ultrasound (r = 0.920). The primary obstacle for sonographic imaging was the presence of air within the burr hole or the subdural space, which typically resolved over time after surgery.

CONCLUSION:
Trans-burr hole sonography emerges as a promising technique for postoperative monitoring of CSDH, with the potential to safely reduce reliance on CT scans and associated radiation exposure in selected patients. Our results support further investigation into the extended use of sonography during the follow-up phase. Prospective multicenter studies are recommended to establish the method's efficacy and to explore strategies for minimizing air presence postsurgery.
Physical Activity and Obesity Risk in Adults in Colombia: The Prospective Urban Rural Epidemiology (PURE) Study
Authors: O’DONOVAN GARY , MARTÍNEZ DANIEL , LÓPEZ-LÓPEZ JOSE P. , OTERO JOHANNA , URINA MANUEL , VASQUEZ TATIANA , NIÑO MONICA , NARVAEZ CLAUDIA , CAMPO MARÍA CAMILA , PEREZ-MAYORGA MARITZA , RODRÍGUEZ SHISLEM , ARCOS EDGARD , SANCHEZ GREGORIO , GARCÍA HENRY , RANGARAJAN SUMATHY , YUSUF SALIM , LÓPEZ-JARAMILLO PATRICIO 
Published: April 2024

ABSTRACT

Purpose
This study aimed to investigate longitudinal associations between physical activity levels and obesity in adults in Colombia, where participation in large amounts of light-intensity physical activity is a necessity for many people.

Methods
Participation in moderate- and vigorous-intensity physical activity was assessed from 2005 to 2009, and obesity was assessed from 2011 to 2019 in men and women from the Prospective Urban Rural Epidemiology (PURE) study. Total physical activity level was categorized as low (<600 MET·min·wk−1), medium (600–3000 MET·min·wk−1), or high (>3000 MET·min·wk−1; 600 MET·min·wk−1 is equivalent to 150 min of moderate activity or 75 min of vigorous activity per week). Obesity was defined as body mass index ≥30 kg·m−2. Analyses were adjusted for age, sex, smoking, socioeconomic status, diet, alcohol, sedentary time, and sleep.

Results
The main analysis included 3086 men and women aged 51 ± 9 yr at baseline (mean ± SD). Compared with the low physical activity group, the odds ratio (95% confidence interval) for obesity was 0.67 (0.53–0.85) in the medium physical activity group and 0.78 (0.62–0.98) in the high physical activity group after adjustment for potential confounders. Smoking is probably a major confounder, and it is noteworthy that similar associations were observed in participants who reported never smoking.

Conclusions
The PURE study is the only prospective cohort study in Colombia. The present analysis is important because it suggests that even the busy people of Colombia could substantially reduce their risk of obesity by participating in moderate- and vigorous-intensity physical activity.
Comprehensive Review of Mastocytosis From Pathophysiology to Management Strategies
Authors: Marchaj Magdalena , Basiaga Bartosz , Żądecka-Kobiałka Klaudia , Putra Anna , Bednarz Karolina , Nowicka-Jasińska Monika , Frączyk Paweł , Bieniek-Zając Sara , Baczkowski Sebastian , Krawiec Klaudia 
Published: April 2024

Introduction: Mastocytosis is a rare hematologic neoplasm characterized by the abnormal proliferation and accumulation of mast cells in various tissues. Its clinical manifestations vary widely, ranging from cutaneous lesions to systemic involvement with potentially life-threatening symptoms. Understanding the pathophysiology, diagnosis, and management of mastocytosis is crucial for improving patient outcomes.

Aim of the Study: The aim of this study was to provide a comprehensive overview of mastocytosis, including its epidemiology, risk factors, pathophysiology, clinical manifestations, diagnostic approaches, and management strategies. By synthesizing current knowledge on mastocytosis, this study aims to enhance understanding of the disease and guide clinical practice.

Description of the State of Knowledge: Mastocytosis is classified into cutaneous and systemic forms, with various subtypes based on clinical and histopathological features. Diagnosis relies on a combination of clinical suspicion, serum tryptase levels, histological examination of bone marrow biopsies, and genetic testing. Management strategies include symptomatic treatment, avoidance of triggers, and targeted therapies such as monoclonal antibodies and tyrosine kinase inhibitors. Advanced forms may require cytoreductive therapy or allogeneic hematopoietic stem cell transplantation (alloHSCT).

Conclusions: Despite advancements in diagnosis and treatment, achieving lasting remission in mastocytosis remains challenging, especially in advanced cases. Further research into the molecular mechanisms underlying the disease and the development of novel therapeutic modalities are needed to improve patient outcomes and quality of life.
Commentary on “Frontiers: Breaking the Glass Ceiling: Empowering Female Entrepreneurs Through Female Mentors”
Authors: Zhang Ting 
Published: April 2024

Mentoring is vital to developing talent. A critical puzzle in designing mentorship programs involves how mentors are matched to mentees: Would mentees benefit more from mentors with a similar or different demographic background? The article [Germann F, Andersen S, Chintagunta P, Vilcassim N (2024) Frontiers: Breaking the glass ceiling: Empowering female entrepreneurs through female mentors. Marketing Sci., 43(2):239–468] highlights that women entrepreneurs benefit more from having women as mentors relative to men as mentors. In this commentary, I highlight how the implications of this paper depend in part on our understanding of the potential mechanisms underlying the benefits of same-gender mentoring relationships for women. I posit that these benefits stem from differences not only in mentors’ provision of psychosocial support but also in their coaching and sponsorship behaviors. By considering these different mechanisms, I propose an alternative implication that involves training mentors to engage in more appropriate coaching and sponsorship behaviors. Thus, I expand the implications of this article from mentor matching to mentor training. I propose that, by learning how effective mentors coach and sponsor women, mentors in cross-gender relationships can be better equipped to help their mentees. History: Catherine Tucker served as the senior editor for this article.
Recurrent infective endocarditis of the mitral valve after orthotopic heart transplantation
Authors: Snopek Peter , Hasilla Jozef , Patrovič Lukáš , Juskanič Dominik , Benko Jakub , Péč Martin Jozef , Samoš Matej 
Published: April 2024

Introduction: Orthotopic heart transplantation is the gold standard for the treatment of advanced heart failure in the absence of contraindications. Infective endocarditis is a rare complication in patients after heart transplantation. The treatment of endocarditis after heart transplantation is challenging since there is a need for ongoing immunosuppression. Case description: We present the case of a 51-year-old orthotopic heart transplant recipient enrolled in a chronic dialysis program, in whom we diagnosed and successfully treated recurrent infective endocarditis of the mitral valve caused by Enterococcus and Enterobacter species. Despite the complicated course of the disease, the treatment was successful. Conclusions: Recurrent infective endocarditis after heart transplantation can be treated successfully with a multidisciplinary approach and robust antimicrobial therapy.
Efficient fiber coupling system for simultaneous beam shaping and wavelength combining based on misaligned stepped prism multiplexing
Authors: Liu Chang , Xue Lirui , Yan Ziyi , Qian Qinyu , Chen Haitao , Cheng Liwen 
Published: April 2024

Due to the substantial contrast in the output beam quality between the two directions
of the semiconductor laser, efficiently coupling the beam directly
into the fiber is difficult. In this study, an efficient shaping
method based on step multiplexing of misaligned step prisms is
proposed and investigated systematically. First, multiple laser stacks
eliminate dark areas to improve the beam quality through the full
utilization of the transmission and reflection surfaces of the
misaligned stepped prisms, which also improves the efficiency of the
stepped prisms. It also simultaneously realizes laser wavelength
combining based on reflective surface multiplexing without affecting
the quality of the beam on the premise of improving the output power.
Finally, the whole beam shaping system is completed without using
cut-transform-rearranging prisms. The method couples four groups of
laser stacks into a single fiber with a fiber diameter of
400 µm and a numerical aperture of 0.22. It can be seen from
the computer-simulated model outputs that the final fiber output power
can reach 2255.4 W and that the system as a whole has a
light-to-light translation rate of 88.1%.
Bioinformatics and system biology approaches to determine the connection of SARS-CoV-2 infection and intrahepatic cholangiocarcinoma
Authors: Zhou Xinyi , Huang Tengda , Pan Hongyuan , Du Ao , Wu Tian , Lan Jiang , Song Yujia , Lv Yue , He Fang , Yuan Kefei 
Published: April 2024

Introduction
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of coronavirus disease 2019 (COVID-19), has infected millions of individuals worldwide, which poses a severe threat to human health. COVID-19 is a systemic ailment affecting various tissues and organs, including the lungs and liver. Intrahepatic cholangiocarcinoma (ICC) is one of the most common liver cancer, and cancer patients are particularly at high risk of SARS-CoV-2 infection. Nonetheless, few studies have investigated the impact of COVID-19 on ICC patients.

Methods
With the methods of systems biology and bioinformatics, this study explored the link between COVID-19 and ICC, and searched for potential therapeutic drugs.

Results
This study identified a total of 70 common differentially expressed genes (DEGs) shared by both diseases, shedding light on their shared functionalities. Enrichment analysis pinpointed metabolism and immunity as the primary areas influenced by these common genes. Subsequently, through protein-protein interaction (PPI) network analysis, we identified SCD, ACSL5, ACAT2, HSD17B4, ALDOA, ACSS1, ACADSB, CYP51A1, PSAT1, and HKDC1 as hub genes. Additionally, 44 transcription factors (TFs) and 112 microRNAs (miRNAs) were forecasted to regulate the hub genes. Most importantly, several drug candidates (Periodate-oxidized adenosine, Desipramine, Quercetin, Perfluoroheptanoic acid, Tetrandrine, Pentadecafluorooctanoic acid, Benzo[a]pyrene, SARIN, Dorzolamide, 8-Bromo-cAMP) may prove effective in treating ICC and COVID-19.

Conclusion
This study is expected to provide valuable references and potential drugs for future research and treatment of COVID-19 and ICC.
Breathing Aesthetics, Jean-Thomas Tremblay (2022)
Authors: Engelmann Sasha 
Published: April 2024

Review of: Breathing Aesthetics, Jean-Thomas Tremblay (2022)
Durham, NC: Duke University Press, 232 pp., photos, illus., notes, bibliog
ISBN 978-1-47801-886-5, p/bk, $25.95
ISBN 978-1-47801-622-9, h/bk, $118.16
National medical eligibility criteria for contraceptive use 2023: review
Authors: Sukhikh G. T. , Prilepskaya V. G. , Aganezova N. V. , Andreeva E. N. , Baranov I. I. , Dolgushina N. V. , Zarochentseva N. V. , Karakhalis L. Yu. , Katkova N. Yu. , Kepsha M. A. , Mezhevitinova E. A. , Nazarenko E. G. , Nazarova N. M. , Podzolkova N. M. , Smetnik A. A. , Tapilskaya N. I. , Uvarova E. V. , Hamoshina M. B. , Chernukha G. E. , Yakushevskaya O. V. , Dzhenina O. V. , Yarmolinskaya M. I. 
Published: April 2024

Individual sexual and reproductive life management has been сonfirmed by medical and state communities since 1990s. Every citizen officially received rights for access to appropriate goods and services. Such international agreements as 1994 International Conference on Population and Development (ICPD, Cairo, Egypt) and 2004 WHO Reproductive health strategy, estimated reproductive health and family planning as priorities. Worldwide agreement on the 2005 summit declares achieving of female reproductive health before year 2015 as worldwide progress.WHO created complex of international eligibility criteria for male and female contraception with the aim of medical aid improvement. According to WHO plan, those criteria should be used by countries considering policy, needs, priorities and resources of national healthcare programs. For example, USA, United Kingdom, Russia etc. have successfully adopted medical eligibility criteria for contraception on the national level.The present review is summary product created by interdisciplinary expert group including representers of federal and regional healthcare establishments, medical universities, and international medical organizations.
The role of repeat kidney biopsy in patients with lupus nephritis (case report)
Authors: Nikishin N. Yu. , Aseeva E. A. , Mesnyankina A. A. , Soloviev S. K. , Stolyarevich E. S. , Zelenov V. A. , Lila A. M. 
Published: April 2024

Lupus nephritis (LN) occurs in 35–60% of patients with systemic lupus erythematosus (SLE), often in the early stages of the disease. LN is one of the most severe manifestations of SLE and, if not treated promptly and effectively, can lead to rapid and severe loss of kidney function. Despite modern pharmacotherapy, 5–20% of patients develop end-stage renal failure within 10 years of diagnosis of LN. The main principle of LN therapy is to prevent deterioration of renal function, but a consensus on outcome assessment criteria and clinically relevant short- and long-term goals for LN therapy has not yet been reached. There is increasing evidence of the importance of repeat kidney biopsies to assess the outcomes of the initial phase of therapy and to determine the long-term prognosis of renal failure. It is believed that the information obtained from repeat biopsies can help to make optimal treatment decisions and thus increase the likelihood of achieving a complete renal response in the short term and a more favorable renal prognosis in the long term.We describe a clinical case of a young patient with highly active SLE and morphologically confirmed class IV-S LN. Repeat biopsy and clinical and laboratory examination, had confirmed a clinical and laboratory remission of the disease on the background of the therapy. This made it possible to reduce the dose of methylpednisolone and cytostatic drugs (mycophenolate mofetil) and to discontinue therapy with biologic diseasemodifying antirheumatic drug (rituximab).
A novel mouse model carrying a gene trap insertion into the Hmgxb4 gene locus to examine Hmgxb4 expression in vivo
Authors: Wang Liang , He Xiangqin , Hu Guoqing , Liu Jinhua , Kang Xiuhua , Yu Luyi , Dong Kunzhe , Zhao Juanjuan , Zhang Aizhen , Zhang Wei , Brands Michael W. , Su Huabo , Zheng Zeqi , Zhou Jiliang 
Published: April 2024

AbstractHMG (high mobility group) proteins are a diverse family of nonhistone chromosomal proteins that interact with DNA and a wide range of transcriptional regulators to regulate the structural architecture of DNA. HMGXB4 (also known as HMG2L1) is an HMG protein family member that contains a single HMG box domain. Our previous studies have demonstrated that HMGXB4 suppresses smooth muscle differentiation and exacerbates endotoxemia by promoting a systemic inflammatory response in mice. However, the expression of Hmgxb4 in vivo has not fully examined. Herein, we generated a mouse model that harbors a gene trap in the form of a lacZ gene insertion into the Hmgxb4 gene. This mouse enables the visualization of endogenous HMGXB4 expression in different tissues via staining for the β‐galactosidase activity of LacZ which is under the control of the endogenous Hmgxb4 gene promoter. We found that HMGXB4 is widely expressed in mouse tissues and is a nuclear protein. Furthermore, the Hmgxb4 gene trap mice exhibit normal cardiac function and blood pressure. Measurement of β‐galactosidase activity in the Hmgxb4 gene trap mice demonstrated that the arterial injury significantly induces Hmgxb4 expression. In summary, the Hmgxb4 gene trap reporter mouse described here provides a valuable tool to examine the expression level of endogenous Hmgxb4 in both physiological and pathological settings in vivo.
Marked on the voice: the visibility experiences of Russian heritage migrants following the war against Ukraine
Authors: Davydenko Sofia , Henry Alastair 
Published: April 2024

Abstract
Identities fundamental to the self, such as race and gender, can operate through visual markers on the body. Identities related to a person’s heritage, or nationality, can also become visible. However, when physical appearance means that a person can pass as a member of a dominant group, being identified or ‘marked’ as other takes place through language use. In migration contexts, situations where a person’s heritage or nationality is revealed can lead to experiences of vulnerability. This study investigated the experiences of five Russian-speaking women living in Sweden whose migrant backgrounds were not visibly noticeable, up until the point that interaction was initiated. Interviews were carried out in the summer of 2022 during the Russian invasion of Ukraine. Data was analysed using a double hermeneutic approach. Findings revealed how, following the outbreak of the war, the fear of becoming visible increased. Fears of exposure triggered vigilant behaviours, and an experience of needing to regulate visibility. Results show how the experience of having situational control over visibility could buffer against emotional pain caused by perceptions of negative positionings, and the risk of prejudicial treatment.
Examination of quality of life and psychiatric symptoms in childhood Graves’ disease
Authors: Yazkan Akgül Gözde , Köprülü Özge 
Published: April 2024

Abstract

Objectives
The aim of our study is to examine the emotional, behavioral problems, and psychiatric symptoms of children diagnosed with Graves’ disease (GD), to assess their quality of life, and to compare with control group.

Methods
The research was planned as a cross-sectional study and included 16 patients with GD (13 female and three male) and 29 healthy children for control group (19 female and 10 male). Sociodemographic form, Pediatric Quality of Life Inventory, Revised Child Anxiety and Depression Scale-Child Version (RCADS-CV), Strengths and Difficulties Questionnaire (SDQ), Turgay DSM-IV-Based Child and Adolescent Behavior Disorders Screening and Rating Scale (T-DSM-IV-S), and Affective Reactivity Index scale were applied to the children and their families.

Results
Eighty one percent of GD group (GG) (n=13, mean age 15.1 ± 2.2) and 66 % of control group (CG) (n=19, 14.6 ± 2.2) were girls. No significant difference was found between GG and CG in terms of quality of life, anxiety, and depression scores. GG had higher scores in affective reactivity index, SDQ-P total score, and T-DSM-IV-S total scores (p values 0.039; 0.009; 0.023, respectively). While no significant difference was detected in the T-DSM-IV-S-inattention and hyperactivity scores, significantly higher scores were detected in oppositional defiance and conduct disorder scores (p values 0.172; 0.294; 0.019; 0.027, respectively).

Conclusions
In children with GD, irritability, oppositional defiant, and conduct disorder symptoms have been detected. Children with these mental health symptoms experience behavioral and emotional difficulties in their daily lives. It is important to follow up children with GD for possible comorbid psychiatric disorders.
Crystal structure of benzo[d][1,3]dioxol-5-ylmethyl 2-(6-methoxynaphthalen-2-yl)propanoate, C22H20O5
Authors: Bai Yang , Zhang Xin-Ru , Hao Duo , Gu Ye 
Published: April 2024

Abstract
C22H20O5, orthorhombic, P212121 (no. 19), a = 5.8585(3) Å, b = 16.2727(10) Å, c = 18.4886(11) Å, V = 1762.59(18) Å3, Z = 4, Rgt
(F) = 0.0276, wRref
(F
2) = 0.0700, T = 100(2) K.
Metal-for-Amber in the European Bronze Age
Authors: Vandkilde Helle , Fischer Stephansen Clara , Suchowska-Ducke Paulina , Ahlqvist Laura , Skaaning Andersen Casper , Felding Louise , Bjørnevad-Ahlqvist Mathias , Czebreszuk Janusz , Nørgaard Heide Wrobel 
Published: April 2024

Abstract
Baltic amber is often considered the principal Scandinavian commodity exchanged for metal from ore-rich regions in Europe. If correct, this may explain the astonishing metal wealth of the Nordic Bronze Age and the modest social consumption of amber locally. The hypothesis of a metal-for-amber principle behind the trade is here for the first time assessed on scales from micro to macro. Amber finds were charted across Europe, and the result was then compared to evidence for regular shifts in copper ore preferences/availability, as found in the systematically changing isotopic/elemental composition of Nordic metal objects in c. 2100–1200 BC. Comparisons indicate that amber and metal followed similar spatiotemporal trajectories with major reorganizations at the turn from the Early to the Middle Bronze Age. Shifts in amber distribution correlate with the geography of metal sources used in both periods and flows of metal to Scandinavia and amber to Europe appear to be contingent even in subperiods. Major European amber tracks – and the crossroads hubs controlling them – were identified for the transfer of goods, yet again revealing major changes at the transition to the Middle Bronze Age. The social roles and meanings of amber among Nordic communities were likewise examined, suggesting that bearers of amber played a role in exercising social control of this resource. It is concluded that amber almost certainly was exchanged for metal.