bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unraveling the role played by a buried mud diapir: alternative model for 2016 Mw 6.4 MeiNong earthquake in southwestern Taiwan
Authors: Lin Geng-Pei , Chang Wu-Lung , Chiu Chi-Yu 
Published: April 2024

AbstractSouthwestern Taiwan exhibits multiple fold-thrust systems as a consequence of the interaction between the Philippine Sea Plate and the Eurasian Plate. A prominent geological feature of this region is the extensive layer of GuTingKeng mudstone, with a thickness of approximately 4 km, which serves as a source material for the formation of mud or shale diapirs. The 2016 Mw 6.4 Meinong earthquake, striking southwestern Taiwan at a depth of 15–20 km and inducing approximately 100 mm of uplift, has prompted investigations into the potential involvement of shallow structures (< 4 km) in this uplift. Recent studies have proposed that such shallow structures may have contributed significantly to the observed uplift during the earthquake. This study aims to elucidate the role of buried mud diapirs in the context of coseismic deformation. Here, we present a modeling approach that utilizes sill-like dislocations to simulate the deformation at the upper tip of the diapir. Our results indicate a vertical opening of approximately 60 mm at a depth of 1.4 km, which closely aligns with the spatial distribution of tomographic and gravity anomalies. We also examine how the coseismic stress changes induced by the Meinong earthquake can lead to a dilatational strain of about 1.2 microstrain within the shallow depth range of 0–4 km, resulting in extension within our modeled region. In contrast, the dilatational strain diminishes from 0.2 to − 1.2 microstrain at greater depths (4–8 km), implying compression in the subsurface beneath the diapir's top. This study discusses the potential mechanisms how fluid-rich and high-pressure mudstone may be deformed through coseismic process and how mud diapirs may contribute to additional deformation within the seismic cycle.
Lung behavior during a staircase high-frequency oscillatory ventilation recruitment maneuver
Authors: de Jager Pauline , Koopman Alette A. , Markhorst Dick G. , Kneyber Martin C. J. 
Published: April 2024

Abstract
Background
Lung volume optimization maneuvers (LVOM) are necessary to make physiologic use of high-frequency oscillatory ventilation (HFOV), but lung behavior during such maneuvers has not been studied to determine lung volume changes after initiation of HFOV, to quantify recruitment versus derecruitment during the LVOM and to calculate the time to stabilization after a pressure change.

Methods
We performed a secondary analysis of prospectively collected data in subjects < 18 years on HFOV. Uncalibrated respiratory inductance plethysmography (RIP) tracings were used to quantify lung recruitment and derecruitment during the LVOM inflation and deflation. The time constant was calculated according to the Niemann model.

Results
RIP data of 51 subjects (median age 3.5 [1.7–13.3] months) with moderate-to-severe pediatric acute respiratory distress syndrome (PARDS) in 85.4% were analyzed. Lung recruitment and derecruitment occurred during the LVOM inflation phase upon start of HFOV and between and within pressure changes. At 90% of maximum inflation pressure, lung derecruitment already started during the deflation phase. Time to stable lung volume (time constant) could only be calculated in 26.2% of all pressure changes during the inflation and in 21.4% during the deflation phase, independent of continuous distending pressure (CDP). Inability to calculate the time constant was due to lack of stabilization of the RIP signal or no change in any direction.

Conclusions
Significant heterogeneity in lung behavior during a staircase incremental–decremental LVOM occurred, underscoring the need for higher initial inflation pressures when transitioning from conventional mechanical ventilation (CMV) and a longer time between pressure changes to allow for equilibration.
EDUBox: finding suitable locations for offgrid mobile classrooms in the context of underserved communities
Authors: Martinetti Alberto , Trauernicht Nina , Dietrich Margot , Chemweno Peter 
Published: April 2024

AbstractThe refugee crisis and the COVID-19 pandemic continue to negatively impact access to education, and especially disproportionately affect underserved communities. Apart from access, such communities experience additional barriers including inadequate classroom infrastructure and suitable localization of such infrastructure. This paper aims to provide an analytical framework to identify the most suitable locations for mobile classrooms for underserved communities, thereby mitigating the lack of access to equitable education for underserved communities. To construct the analytical framework, we conduct a critical literature review to conceptualize the educational needs of underserved communities. Next, we proposed parameters that may be applicable for determining locationally metrics that match the educational needs of underserved communities. On this basis, we explore tools and methods applicable for suitability analysis and developed a geo-information framework that integrates an analytical hierarchy process tool to prioritize parameters decision-makers can apply to identify optimal areas to locate classroom infrastructure. This framework was applied to a use case of determining suitable location areas for an innovative mobile classroom (EDUBox) in Jordan. Using the framework, we demonstrate its applicability by identifying appropriate locations adapted to the tertiary and vocational education needs of underserved persons including refugee communities.
Graphical Abstract
Motivations matter: moral and health-related motives indirectly relate to differential psychological health indicators among vegetarians
Authors: Dai Xiaoyu , Leung Angela K.-Y. 
Published: April 2024

AbstractDue to rising popularity of vegetarianism in recent years, research interest has surged in examining the relationship between vegetarianism and psychological health. However, given inconsistent findings in prior research, the answer to whether practicing vegetarianism is associated with better or worse psychological health is still elusive. The present investigation aimed to demonstrate that vegetarians are not homogeneous in terms of psychological experiences, such that it is crucial to consider the motives behind vegetarians’ dietary choice when examining their psychological health. In a survey study with 266 vegetarians and 104 omnivores, it was shown that health vegetarians displayed higher levels of disordered eating as compared to moral vegetarians and omnivores. Mediation analyses further revealed that, among vegetarians, health motivation was positively correlated with disordered eating tendencies, indirectly linking it with poorer psychological health; moral motivation was positively correlated with prosocial behavior, which in turn predicted better psychological health. These findings have implications for understanding the psychological health of vegetarians with different dietary motives and for developing interventions to promote their psychological health.
Unraveling the genetic collagen connection: clinical and therapeutic insights on genetic connective tissue disorders
Authors: Salles Rosa Neto Nilton , Pereira Ivânio Alves , Sztajnbok Flávio Roberto , Azevedo Valderílio Feijó 
Published: April 2024

AbstractHereditary connective tissue disorders include more than 200 conditions affecting different organs and tissues, compromising the biological role of the extracellular matrix through interference in the synthesis, development, or secretion of collagen and/or its associated proteins. The clinical phenotype includes multiple signs and symptoms, usually nonspecific but of interest to rheumatologists because of musculoskeletal involvement. The patient´s journey to diagnosis is long, and physicians should include these disorders in their differential diagnoses of diseases with systemic involvement. In this review, insights for the diagnosis and treatment of osteogenesis imperfecta, hypermobility spectrum disorder/Ehlers–Danlos syndrome, Marfan, Loeys–Dietz, and Stickler syndromes are presented.
Recommendations for the organization of the teleconsultation service in a telestroke network
Authors: Wiestler Hanni , Zickler Philipp , Erdur Hebun , Abu-Mugheisib Mazen , Kallmünzer Bernd , Klingner Caroline , Müller-Barna Peter , Hubert Gordian , Gumbinger Christoph , Worthmann Hans 
Published: April 2024

AbstractTelestroke networks aim to improve acute stroke care within their catchment area. Through a teleconsultation service, the network centers provide support to network hospitals that lack continuous neurological expertise for acute stroke management decisions. Although the importance of telemedical treatment in stroke care is steadily increasing, so far no standards exist for the organization of the teleconsultation service in networks.To ensure a high-level of quality for all processes and measures concerning telemedical stroke treatment, the commission for telemedical stroke care of the German Stroke Society (Deutsche Schlaganfall-Gesellschaft, DSG) created the following recommendations on how to organize a teleconsultation service within a telestroke network. The recommendations are the result of an adjustment process between the authors and include guidance on requirements, qualifications, processes and quality management within the teleconsultation service.
Entropy generation analysis for magnetohydrodynamic flow of chemically reactive fluid due to an accelerated plate
Authors: Abdelhameed T. N. 
Published: April 2024

Abstract
Background
The mixed convection flow of viscous fluid due to an oscillating plate is inspected. The external heating effects and chemical reaction assessment are predicted. Moreover, the flow applications of the entropy generation phenomenon are claimed.

Results
The dimensionless system is expressed in partial differential forms, which are analytically treated with the Laplace scheme. The physical aspects of the flow model are graphically observed. The optimized phenomenon is focused on flow parameters. The results for the Bejan number are also presented. The dynamic of heat transfer and entropy generation phenomenon is observed with applications of Bejan number.

Conclusions
It is claimed that an enhancement of entropy generation phenomenon is noticed due to heat and mass Grashof coefficients. The Bejan number declined due to mass Grashof number. Furthermore, the velocity profile boosted due to Grashof constant.
A novel rock-physics model of organic-rich shale considering maturation influence
Authors: Yang Rui , Chen Huaizhen 
Published: April 2024

Geochemical parameters, e.g., maturity and total organic carbon (TOC) content, play a crucial role in the prediction of sweet spots and the exploration of oil and gas in organic-rich shales. Thermal maturity significantly affects the conversion of solid organic matter into hydrocarbons and the evolution of microstructures, thereby altering the overall elastic properties of shales. To clarify how maturity affects shale properties, we develop a novel rock-physics model (RPM) of organic-rich shale, in which we consider the continuous process of thermal maturity. First, we present how to estimate the maturity level, TOC content, and organic porosity using logging data. Second, different from only considering the discrete-stage maturity, we establish a novel RPM in which a continuous kerogen maturation process serves as a key control condition. Furthermore, we calibrate the volumetric proportion of each porosity type as a function of maturation. Finally, we apply the RPM to investigate how sweet spot parameters (thermal maturity, TOC content, and brittle mineral content), overpressure, and diagenesis affect the overall elastic properties and anisotropy of shale during thermal maturation. Results demonstrate that using our RPM, we may predict the acoustic velocity of shale formations reliably and that kerogen evolution has a noticeable impact on the elastic properties of shale rocks, particularly during the wet gas window stage of mid-to-high maturation. We conclude that thermal maturity emerges as a crucial sweet spot parameter in the case of the exploration of oil and gas in organic-rich shales.
Towards synthetic magnetic turbulence with coherent structures
Authors: Lübke Jeremiah , Effenberger Frederic , Wilbert Mike , Fichtner Horst , Grauer Rainer 
Published: April 2024

Abstract
Synthetic turbulence is a relevant tool to study complex astrophysical and space plasma environments inaccessible by direct simulation. However, conventional models lack intermittent coherent structures, which are essential in realistic turbulence. We present a novel method featuring coherent structures, conditional structure function scaling and fieldline curvature statistics comparable to magnetohydrodynamic turbulence. Enhanced transport of charged particles is investigated as well. This method presents significant progress towards physically faithful synthetic turbulence.
From Bench-to-Bedside: How Artificial Intelligence is Changing Thyroid Nodule Diagnostics, a Systematic Review
Authors: Sant Vivek R , Radhachandran Ashwath , Ivezic Vedrana , Lee Denise T , Livhits Masha J , Wu James X , Masamed Rinat , Arnold Corey W , Yeh Michael W , Speier William 
Published: April 2024

Abstract

Context
Use of artificial intelligence (AI) to predict clinical outcomes in thyroid nodule diagnostics has grown exponentially over the past decade. The greatest challenge is in understanding the best model to apply to one's own patient population, and how to operationalize such a model in practice.

Evidence Acquisition
A literature search of PubMed and IEEE Xplore was conducted for English-language publications between January 1, 2015 and January 1, 2023, studying diagnostic tests on suspected thyroid nodules that used AI. We excluded articles without prospective or external validation, nonprimary literature, duplicates, focused on nonnodular thyroid conditions, not using AI, and those incidentally using AI in support of an experimental diagnostic outside standard clinical practice. Quality was graded by Oxford level of evidence.

Evidence Synthesis
A total of 61 studies were identified; all performed external validation, 16 studies were prospective, and 33 compared a model to physician prediction of ground truth. Statistical validation was reported in 50 papers. A diagnostic pipeline was abstracted, yielding 5 high-level outcomes: (1) nodule localization, (2) ultrasound (US) risk score, (3) molecular status, (4) malignancy, and (5) long-term prognosis. Seven prospective studies validated a single commercial AI; strengths included automating nodule feature assessment from US and assisting the physician in predicting malignancy risk, while weaknesses included automated margin prediction and interobserver variability.

Conclusion
Models predominantly used US images to predict malignancy. Of 4 Food and Drug Administration–approved products, only S-Detect was extensively validated. Implementing an AI model locally requires data sanitization and revalidation to ensure appropriate clinical performance.
Clinical Activity of Selpercatinib in RET-mutant Pheochromocytoma
Authors: Deschler-Baier Barbara , Konda Bhavana , Massarelli Erminia , Hu Mimi I , Wirth Lori J , Xu Xiaojian , Wright Jennifer , Clifton-Bligh Roderick J 
Published: April 2024

Abstract

Context
Activating RET alterations have been reported in a variety of solid tumors, including pheochromocytoma where they occur both sporadically and as part of familial multiple endocrine neoplasia type 2 (MEN2) syndromes. Selpercatinib is a first-in-class, highly selective, and potent small molecule RET kinase inhibitor that has demonstrated marked and durable antitumor activity in diverse RET-activated solid tumors in the LIBRETTO-001 study (NCT03157128).

Methods
We describe the first 6 pheochromocytoma cases treated with selpercatinib in the LIBRETTO-001 study.

Results
Of the 6 patients (1 sporadic and 5 reported as part of MEN2 syndromes) in this case report, 4 had a partial response/complete response and 2 had stable disease per independent review committee. Treatment duration ranged from 9.2 months to more than 56.4 months. The safety profile of treatment was consistent with selpercatinib in other indications.

Conclusion
These data support selpercatinib as an effective therapy against RET-mutant pheochromocytoma, adding to the diversity of RET-activated tumor types that may benefit from targeted RET inhibition.
Lutosławski's Mid-Century Harmony
Authors: Martins José Oliveira 
Published: April 2024

Abstract
This article proposes to expand our understanding of Witold Lutosławski's chordal space and its relation to formal processes. It argues that the traditional analytical focus on harmonic colors of isolated chords comes at the expense of understanding how chordal interactions shape form. How do individual chords participate in cogent, expressive, and sensuous long-range harmonic processes? The article explores how the arrangement of intervals in twelve-tone chords (especially the ordering, restriction, and modularity of intervals) not only imprint distinct coloristic qualities to single chordal entities but are also implicated in strategies of harmonic progression, relatedness, complementarity, and contrast. These analytical goals prompt a reconceptualization of chordal elements, which are understood as combinations of pitch class and modal quality rather than simply as pitches in register. The analytical focus is on Lutosławski's harmony of the mid- to late fifties, attending in particular to the Five Iłłakowicz Songs, the composer's inaugural effort in the use of vertical aggregates. Lutosławski's chordal space in these pieces is interpreted through a series of cyclic graphs and transpositional networks, prompting a novel understanding between twelve-tone chordal harmony and form. The study proposes to contribute to the analytical reappraisal of a set of pieces that anchor an influential harmonic practice in twentieth- and twenty-first-century music.
Schemata, Splices, and Elisions in Monteverdi's Book 5 Madrigals
Authors: Schubert Peter 
Published: April 2024

Abstract
Studies of tonality in Monteverdi's madrigals have focused on cadential harmonies at phrase endings, for the most part ignoring the music that comes in between. The present study, focusing on homorhythmic music, identifies three elements lying between chordal arrivals: schemata, splices, and elisions. Schemata are short conventionalized outer-voice progressions that can connect a variety of starting and ending chords; splices are alterations by which the second version of a progression is varied when it is repeated in transposition; and elisions are made by common tones between the last chord of one progression and the first of the next. Each one of these essentially contrapuntal strategies is a crucial building block of Monteverdi's tonal structures: together they contribute to closing tonal circles, to an expressive use of register, and to meaningful changes of texture.
10th European Calcium Society symposium: The Ca2+-signaling toolkit in cell function, health and disease
Authors: Speelman-Rooms Femke , Vanmunster Maarten , Coughlan Aled , Hinrichs Macarena , Pontisso Ilaria , Barbeau Solene , Parpaite Thibaud , Bultynck Geert , Brohus Malene 
Published: April 2024

ABSTRACT
The 10th European Calcium Society symposium, organized in Leuven, Belgium on November 15-17, 2023, focused on the role of Ca2+ signaling in cell function, health and disease. The symposium featured six scientific sessions, 16 invited speakers – of whom two were postdoctoral researchers – and 14 short talks. The talks covered various aspects of intracellular Ca2+ signaling and its implications in pathology. Each session was opened by one or more invited speakers, followed by a series of presentations from speakers selected from submitted abstracts. Through short talks, poster presentations, awards, and sustainable travel fellowships, the symposium also fostered opportunities for the active participation of early-career researchers. At least half of the short talks were allocated to early-career researchers, thereby offering a platform for the presentation of ongoing work and unpublished results. Presentations were also broadcast in real-time for online attendees. In this Meeting Review, we aim to capture the spirit of the meeting and discuss the main take-home messages that emerged during the symposium.
Acto3D: an open-source user-friendly volume rendering software for high-resolution 3D fluorescence imaging in biology
Authors: Takeshita Naoki , Sakaki Shinichiro , Saba Rie , Inoue Satoshi , Nishikawa Kosuke , Ueyama Atsuko , Nakajima Yoshiro , Matsuo Kazuhiko , Shigeta Masaki , Kobayashi Daisuke , Yamazaki Hideya , Yamada Kei , Iehara Tomoko , Yashiro Kenta 
Published: April 2024

ABSTRACT
Advances in fluorescence microscopy and tissue-clearing have revolutionised 3D imaging of fluorescently labelled tissues, organs and embryos. However, the complexity and high cost of existing software and computing solutions limit their widespread adoption, especially by researchers with limited resources. Here, we present Acto3D, an open-source software, designed to streamline the generation and analysis of high-resolution 3D images of targets labelled with multiple fluorescent probes. Acto3D provides an intuitive interface for easy 3D data import and visualisation. Although Acto3D offers straightforward 3D viewing, it performs all computations explicitly, giving users detailed control over the displayed images. Leveraging an integrated graphics processing unit, Acto3D deploys all pixel data to system memory, reducing visualisation latency. This approach facilitates accurate image reconstruction and efficient data processing in 3D, eliminating the need for expensive high-performance computers and dedicated graphics processing units. We have also introduced a method for efficiently extracting lumen structures in 3D. We have validated Acto3D by imaging mouse embryonic structures and by performing 3D reconstruction of pharyngeal arch arteries while preserving fluorescence information. Acto3D is a cost-effective and efficient platform for biological research.
The psoriasis severity, dermatology life quality index and sleep quality: The role of itch intensity and depression
Authors: Kadzikowska-Wrzosek Romana , Wrzosek- Dobrzyniecka Karolina , Szczerkowska-Dobosz Aneta 
Published: April 2024

Aim of the studyTo better understand the origin of sleep quality impairment among psoriasis patients, we sought to examine whether the psoriasis severity, health related life quality, itch and depression are significant predictors of sleep disruption; and whether itch intensity and depression are mediators of the relationship between the health- related life quality and sleep problems.Subject or material and methods42 patients diagnosed with chronic plaque psoriasis, (female: 40.5%; mean age=44.48 years; SD=17.57, age range=21-82) completed Polish versions of: the Pittsburgh Sleep Quality Index (PSQI), the Centre for Epidemiological Studies - Depression scale (CES-D). The itch intensity was measured according to the 10-point visual analogue scale (VAS). The Severity of patient’s psoriasis was evaluated by using The Psoriasis Area Severity Index (PASI), health related life quality was assessed using the Dermatology Life Quality Index (DLQI) .ResultsThe stronger the negative effect of psoriasis on patients’ life as measured by Dermatology Life Quality Index, the greater the sleep disturbances.DiscussionThe results confirm that poor health- related quality of life may account for higher sleep ditrubances among psoriasis patients, and suggest that this negative effect reveals itself, through enhancing depression.ConclusionsIt seems that a greater therapeutic focus on health related quality of life in psoriasis patients may lead to an improvement in their sleep quality.