bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of vitamin D deficiency and low bone mass in children with asthma in fars province: A case‐control study
Authors: Alyasin Soheila , Sadeghi Fateme S. , Saki Forough , Dabaghmanesh Mohamadhosein 
Published: May 2024

AbstractBackground and AimsAsthma is a chronic inflammatory pulmonary disease which affects 10%–20% of children and adolescents. Inhaled corticosteroids (ICS) is one of its most effective therapies. The effect of systemic corticosteroids on decreasing bone mineral density (BMD) was investigated and proved in children; however, the influence of ICSs on bone density has still remained unclear. This study evaluates the bone mineral density of children and adolescents with asthma in southern Iran and the associated factors, for example, amount of used inhaled steroid.MethodThis case‐control study enrolled 41 children and adolescents (aged 8–18 years) with asthma and their age and gender‐matched controls in 2019–2020. Serum Calcium, phosphate, vitamin D, and bone mineral density were measured. Their physical activity, sun exposure, and fracture history were evaluated subjectively.ResultsLumbar BMD and BMD Z‐score in patients showed no significant difference with controls (p = 0.23, p = 0.73). Also, it showed that there was no significant difference in biochemical studies, growth, and bone densitometry parameters between patients who used ICSs for less than 3 months/year corticosteroid therapy compared to those with equal or more than 3 months/year usage. Prevalence of vitamin D deficiency was 28% and 8% in the controls and patients, respectively (p = 0.005).ConclusionThe present study showed that 9.46% of children and adolescents with asthma had low bone mass for chronological age, and it is not significantly higher than normal population. Dosage of inhaled steroid did not associate with osteoporosis in these patients. Prevalence of vitamin D deficiency in patients was lower than normal population, probably due to receiving vitamin D in their routine follow‐ups.
UBE2T mediates SORBS3 ubiquitination to enhance IL‐6/STAT3 signaling and promote lung adenocarcinoma progression
Authors: Pu Jiangtao , Wang Biao , Zhang Dengguo , Wang Kaiqiang , Yang Ze , Zhu Peiquan , Song Qi 
Published: May 2024

AbstractUBE2T is an oncogene in varying tumors, including lung adenocarcinoma (LUAD). SORBS3 is an important signaling regulatory protein that plays a crucial role in many cancers. This study aimed to investigate whether UBE2T promoted LUAD development by mediating the ubiquitination of SORBS3 and further explore its mechanism. Bioinformatics analysis was conducted to examine the expression of SORBS3 in LUAD tissues. Cell Counting Kit‐8, Transwell, and flow cytometry were employed to analyze the cellular functions of SORBS3. Co‐immunoprecipitation and ubiquitination analysis were employed to observe the correlation between UBE2T and SORBS3. In vitro and in vivo experiments verified the role of UBE2T in mediating SORBS3 ubiquitination to enhance interleukin‐6/signal transducer and activator of transcription 3 (IL‐6/STAT3) signaling and promote LUAD development. We observed significant downregulation of SORBS3 in LUAD tissues and cells. Furthermore, SORBS3 inhibited the proliferation, migration, and invasion of LUAD cells, while facilitating apoptosis in vitro. UBE2T enhanced IL‐6/STAT3 signaling by mediating ubiquitination and degradation of SORBS3, thereby promoting LUAD progression. Additionally, this mechanism was further validated in the xenograft animal model in vivo. This study confirmed that UBE2T‐mediated SORBS3 ubiquitination enhanced IL‐6/STAT3 signaling and promoted LUAD progression, providing a novel therapeutic target for LUAD.
The diminishing association between adolescent mental disorders and educational performance from 2006–2019
Authors: Nordmo Magnus , Kleppestø Thomas H. , Reme Bjørn‐Atle , Sunde Hans Fredrik , von Soest Tilmann , Torvik Fartein Ask 
Published: May 2024

AbstractBackgroundA rising prevalence of adolescent mental disorders in the Western world has been widely reported, raising concerns for adolescent development and well‐being. Mental disorders are known to negatively impact educational performance. Yet it remains uncertain whether the relationship between mental disorders and educational outcomes has also changed over time and if the change is more pronounced among high compared to low performing students. The aims of this paper are to (1) describe the change over time in the prevalence of common mental disorders in adolescence; (2) determine whether the change in prevalence of common mental disorders differs between high and low performing students; and (3) assess whether the associations between mental health disorders and educational performance have changed over time.MethodsTo address these issues, this study examines potential shifts in the associations between diagnoses of ADHD and internalizing disorders and educational performance among 843,692 Norwegian students graduating from lower secondary education between 2006 and 2019. We utilize population‐wide register data on ADHD and internalizing disorders from primary and specialist care combined with educational outcomes.ResultsOur analysis revealed a marked rise in ADHD prevalence, from 1.0% in 2006 to 2.6% in 2019. Concurrently, diagnoses of internalizing disorders also increased from 1.9% to 4.2%. This increasing trend in diagnoses spanned across all high school grade point average (GPA) categories, thereby not supporting the notion that the rise is predominantly observed among high‐performing adolescents. Importantly, the strength of the associations of internalizing disorders and ADHD with GPA diminished significantly over time. For instance, the difference between the average GPA standardized score for boys with and without an ADHD diagnosis shrunk from 1.0 in 2006 to 0.73 in 2019.ConclusionsWe discuss various potential explanations for this observation and suggest that changes in diagnostic thresholds is a contributing factor.
Age–rank correlations and firm‐level outcomes: The moderating role of environmental dynamism
Authors: De Meulenaere Kim , Kunze Florian , Bruch Heike 
Published: May 2024

SummaryTraditionally, older employees have held higher positions in the organizational hierarchy. However, today, there is significant variation among firms in the extent to which age is correlated with rank. In this study, we integrate the career timetable and social exchange theory to propose that age–rank correlation is related to organizational performance, serially mediated by the perceived age discrimination climate and organizational innovation. We further suggest that the direction of this indirect relationship depends on firms' environmental dynamism. We find support for our moderated serial mediation framework using multisource data from 12,829 employees, 68 top HR representatives, and 229 top managers in 68 firms. Under lower levels of environmental dynamism, age–rank correlation was negatively related to perceived age discrimination climate and had a positive indirect relationship with organizational performance. Under higher levels of environmental dynamism, age–rank correlation was positively related to perceived age discrimination climate and had a negative indirect relationship with organizational performance. Our study provides a more nuanced view of the fading link between age and rank, which has typically been viewed negatively and from an individual perspective only. Additionally, our results have important practical implications for organizations navigating a shifting workforce demographic in increasingly dynamic environments.
Smurf1‐targeting microRNA‐136‐5p‐modified bone marrow mesenchymal stem cells combined with 3D‐printed β‐tricalcium phosphate scaffolds strengthen osteogenic activity and alleviate bone defects
Authors: Duan Gang , Lu Ya‐Fei , Chen Hong‐Liang , Zhu Zi‐Qiang , Yang Shuo , Wang Yun‐Qing , Wang Jian‐Qiang , Jia Xing‐Hai 
Published: May 2024

AbstractSuitable biomaterials with seed cells have promising potential to repair bone defects. However, bone marrow mesenchymal stem cells (BMSCs), one of the most common seed cells used in tissue engineering, cannot differentiate efficiently and accurately into functional osteoblasts. In view of this, a new tissue engineering technique combined with BMSCs and scaffolds is a major task for bone defect repair. Lentiviruses interfering with miR‐136‐5p or Smurf1 expression were transfected into BMSCs. The effects of miR‐136‐5p or Smurf1 on the osteogenic differentiation (OD) of BMSCs were evaluated by measuring alkaline phosphatase activity and calcium deposition. Then, the targeting relationship between miR‐136‐5p and Smurf1 was verified by bioinformatics website analysis and dual luciferase reporter assay. Then, a rabbit femoral condyle bone defect model was established. miR‐136‐5p/BMSCs/β‐TCP scaffold was implanted into the defect, and the repair of the bone defect was detected by Micro‐CT and HE staining. Elevating miR‐136‐5p‐3p or suppressing Smurf1 could stimulate OD of BMSCs. miR‐136‐5p negatively regulated Smurf1 expression. Overexpressing Smurf1 reduced the promoting effect of miR‐136‐5p on the OD of BMSCs. miR‐136‐5p/BMSCs/β‐TCP could strengthen bone density in the defected area and accelerate bone repair. SmurF1‐targeting miR‐136‐5p‐modified BMSCs combined with 3D‐printed β‐TCP scaffolds can strengthen osteogenic activity and alleviate bone defects.
Challenges to Improve Extrusion‐Based Additive Manufacturing Process of Thermoplastics toward Sustainable Development
Authors: Patti Antonella 
Published: May 2024

AbstractThis review aims to present the different approaches to lessen the environmental impact of the extrusion‐based additive manufacturing (MEX) process of thermoplastic‐based resins and protect the ecosystem. The benefits and drawbacks of each alternative, including the use of biomaterials or recycled materials as feedstock, energy efficiency, and polluting emissions reduction, have been examined. First, the technological option of using a pellet‐fed printer was compared to a filament‐fed printer. Then, common biopolymers utilized in MEX applications are discussed, along with methods for improving the mechanical properties of associated printed products. The introduction of natural fillers in thermoplastic resins and the use of biocomposite filaments have been proposed to improve the specific performance of printed items, highlighting the numerous challenges related to their extrusion. Various polymers and fillers derived from recycling are presented as feeding raw materials for printers to reduce waste accumulation, showing the inferior qualities of the resulting goods when compared to printed products made from virgin materials. Finally, the energy consumption and emissions released into the atmosphere during the printing process are discussed, with the potential for both aspects to be controlled through material selection and operating conditions.
A Fluorescent Hydrogel with AIE Emission for Dehydration‐Visualizable Wearable Sensors
Authors: Liu Yanru , Li Yali , Yu Shengsheng , Niu Kaikai , Liu Hui , Xing Ling‐Bao , Ma Shuanhong 
Published: May 2024

AbstractHydrogel‐based wearable sensors eventually experience dehydration, which negatively impacts their function, leading to decreased sensitivity. Monitoring the real‐time water retention rate and sensing performance of wearable flexible sensors without dismantling them remains a significant difficulty. In this study, a molecule having aggregation‐induced emission (AIE) properties in an aqueous environment has been developed and produced, which can combine with anionic guar gum and acrylic acid to create an AIE hydrogel. Wearable sensing electronic devices have the capability to track motion signals at various joints of the human body. Additionally, they can effectively and visually monitor dehydration status during extended periods of operation. The fluorescence intensity of the hydrogel is primarily influenced by the level of aggregation of luminous monomers inside the network. This level of aggregation is predominantly governed by the hydrogel's water retention rate. Hence, the extended duration of hydrogel dehydration can be manifested through alterations in their fluorescence characteristics, which are employed for strain sensing. This approach enables users to assess the water retention of hydrogels with greater efficiency, eliminating the requirement for disassembling them from the completed electrical gadget. In summary, the use of AIE‐based fluorescent hydrogels will advance the progress of intelligent wearable electronics.
Interference characteristics of leaking SF6 on photoacoustic detection of dissolved C2H4 in transformer oil
Authors: Mo Bingyu , Zhou Shanghu , He Yanjiao , Han Xiao , Han Menglong , Li Chenxi , Chen Ke 
Published: May 2024

AbstractSF6 leaked from gas insulation equipment will interfere with the detection of dissolved characteristic gases in transformer oil. In order to determine the impact of SF6 on the detection of dissolved C2H4 gas in oil, a photoacoustic (PA) C2H4 detection system based on the combination of mid‐infrared thermal radiation source and near‐infrared laser was constructed. The excitation light from two bands was incident on a non‐resonant PA cell. The thermal radiation light source and the laser light source were switched to evaluate the interference level of SF6 on the detection of C2H4. The experimental results show that SF6 has significant interference to C2H4 when using a mid‐infrared thermal radiation light source. The interference coefficient is 2014%. The near‐infrared laser based on PA detection method can effectively suppress the interference of SF6 on C2H4. The minimum detection limit of C2H4 reaches 0.6 ppm when the average time is 60 s.
Physicochemical evaluation of polyvinyl alcohol films crosslinked with saturated and unsaturated dicarboxylic acids: A comparative study
Authors: Gautam Leela , Warkar Sudhir G. , Jain Manish 
Published: May 2024

AbstractIn this study, crosslinked films of polyvinyl alcohol (PVA) were prepared using two dicarboxylic acids: saturated succinic acid (SA) and unsaturated maleic acid (MAL) as crosslinkers. The crosslinking capabilities of these acids were compared through physical, chemical, mechanical, morphological, thermal analysis, and swelling measurements to investigate their impact on the physicochemical properties of the resulting films. Attenuated total reflectance fourier transform infrared spectroscopy (FTIR) confirmed the occurrence of an esterification reaction between PVA and the dicarboxylic acids. Based on the degree of crosslinking and thermal properties, it was noted that the crosslinking achieved with maleic acid is more effective for PVA compared with succinic acid. The crosslinking degree of PVA‐MAL was determined to be 6.47 times higher than that of the PVA‐SA film. In terms of thermal stability, the decomposition temperature for crosslinked PVA‐MAL was measured at 365.57°C, whereas PVA‐SA exhibited a slightly lower decomposition temperature of 362.58°C. The findings indicate that the PVA‐MAL film displays lower crystallinity and a higher contact angle (80.60°) in contrast to PVA‐SA (76.0°) and PVA (30.4°). Atomic force microscopy analysis indicated that the PVA‐SA film exhibited more surface roughness compared with the smoother PVA‐MAL film. Also, crosslinked films displayed enhanced elasticity and resilience in comparison with neat PVA, which may be due to the difference in crosslinking density, disruption in intermolecular hydrogen bonding due to crosslinking, and incorporation of flexible crosslinkers.Highlights
PVA was crosslinked using SA and MAL.
Unsaturated MAL exhibited superior crosslinking density over saturated SA.
PVA‐SA film exhibited a porous surface compared to PVA‐MAL film.
PVA crosslinked with unsaturated MAL showed higher thermal stability than SA.
Both the films showed enhanced elasticity and resilience compared with neat PVA.
Myosteatosis and not low muscle mass is associated with lower survival in kidney transplant recipients
Authors: Huitfeldt Sola Kristoffer N.D. , Genberg Helena M. , Avesani Carla M. , Brismar Torkel B. 
Published: May 2024

AbstractBackgroundMyosteatosis, that is muscle fat infiltration, is an important marker of muscle quality, affecting quality of life and survival in patients with chronic kidney disease (CKD). However, the connection between myosteatosis, skeletal muscle index (SMI) and survival in kidney transplant (KTx) recipients remains unclear.MethodsThis retrospective observational study included a cohort of consecutive adult kidney recipients transplanted between 2010 and 2017 in Stockholm. Preoperative abdominal computed tomography (CT) images obtained after diagnosis of CKD 5 and within 36 months of transplantation were collected. Using established criteria, we measured muscle area at the third lumbar vertebra (L3 level) and identified low attenuation muscle, indicating myosteatosis. Each area was divided by height squared providing the SMI, and fatty muscle index (FMI). Given that there is no commonly accepted definition of sarcopenia, two cut‐offs for SMI were used to define low muscle mass, Cut‐off 1 (≤32.8 for women and ≤44.7 for men) and Cut‐off 2 (≤38.5 for women and ≤52.4 for men). Average radiodensity of skeletal muscle and Charlson comorbidity index were calculated for each patient. The influence on survival from SMI, FMI, SMI/FMI ratio, and radiodensity was analysed.ResultsOut of 582 KTx recipients, 266 (46%) had a pre‐transplant abdominal CT available. Applying SMI Cut‐off 1, 30 recipients (11%) had sarcopenia compared with 106 (40%) with Cut‐off 2. Neither SMI nor FMI was associated with survival. Yet there was an association between SMI/FMI ratio and survival, patients with the lowest quintile SMI/FMI ratio having a significantly lower survival when compared with the highest quintile, both in the crude model and when adjusted for age, gender, and comorbidity. Additionally, FMI, radiodensity, and SMI/FMI, but not SMI, were significantly associated with Charlson comorbidity index (P < 0.01).ConclusionsThe SMI/FMI ratio may be associated with both pre‐transplant comorbidity and post‐transplant survival even though the significance of SMI is unclear. This suggests that SMI/FMI ratio is a better indicator of muscular impairment than skeletal muscle quantity alone. The finding may reflect the complex interplay between muscle mass, muscular fat infiltration and metabolic health, all important determinants of wellness and longevity. In summary, our study underscores the potential of the SMI/FMI ratio as a predictor of outcome after KTx, a finding possibly transferable to other patient populations.
An Iminophosphinite Pincer Iridium Complex: Synthesis and Catalytic Tool for Alkane Transfer Dehydrogenations
Authors: Cardozo Jesvita , He Ouchan , Ma Wanli , Ray Kallol , Braun Thomas 
Published: May 2024

AbstractA [(POCN)Ir(H)(OAc)] complex bearing an iminophosphinite pincer ligand was synthesized. The complex showed catalytic transfer dehydrogenation of various linear and cyclic alkanes with reasonable conversions and a maximum TON of 400 for n‐octane. A catalytic isomerization of 1‐octene to yield internal octenes was also possible. It is notable that the catalyst could perform catalytic transfer dehydrogenation even at a temperature of 100 °C with a TON of 100.
Public Organizations’ Social Responsibility and Its Impact on Citizens’ Trust in Public Administration
Authors: Xanthopoulou Panagiota , Sahinidis Alexandros , Horák Jakub , Antoniadis Ioannis , Panagopoulou Maria 
Published: May 2024

AbstractThis study seeks to contribute to the existing body of literature by exploring the relationship between public organizations’ social responsibility initiatives and the level of citizens’ behaviors. By investigating how public organizations’ engagement in socially responsible practices influences citizens’ perceptions of their administrations, this study aims to provide actionable insights for policymakers and administrators. The authors used a quantitative study and data were gathered through online questionnaires from a convenient sample of 104 individuals. Findings showed that socially responsible actions have no significant impact on citizens’ trust on public administration, however, they prefer more responsible public organizations, which promote transparency and protect human rights. The practices that were mainly mentioned referred to the protection of human rights and the protection of the natural environment of the local community where the organization operates. This research serves as a valuable resource for policymakers, practitioners, and researchers aiming to enhance the effectiveness and accountability of public administration through socially responsible actions.
Characteristics of Romanian Travel Bloggers and Generated Content During COVID-19
Authors: Briciu Victor-Alexandru , Briciu Arabela , Bularca Maria Cristina , Dogaru Georgiana 
Published: May 2024

AbstractTourism plays a vital role in the global economy and its promotion relies on a variety of methods, including advertising, social media, and blogging. Traditional travel writing has evolved into digital platforms such as blogs, micro-blogs, and travel apps, changing the way travellers document their journeys. This paper examines the phenomenon of travel blogging and its impact on the tourism industry, focusing on Romanian travel bloggers. We used content analysis to explore our research objectives: to understand the demographics of bloggers, to explore their travel interests, to analyse the topics covered, and to assess the effectiveness of travel blogs. This is particularly important given the challenges facing the tourism industry during the pandemic. In addition, our findings highlight the importance of travel-related blog posts, such as those discussing travel conditions and restrictions during the pandemic. These findings are valuable in both stable and disrupted travel industry contexts. In conclusion, this study reveals the evolving role of travel blogs and their importance in destination development and highlights the adaptability and relevance of travel blogs in different tourism scenarios.
Health Tourism in Greece: The Fertility Center in Crete
Authors: Athanasopoulou Pinelopi , Giovanis Apostolos N. , Gdonteli Krinanthi 
Published: May 2024

AbstractAccording to global health tourism data there were over 23 million health tourists in 2019 and medical tourism is growing rapidly. Greece is one of the most preferred destinations for medical tourism and particularly for fertility treatment. However, research on medical tourism is limited. The purpose of this study is to investigate the inbound tourism for fertility treatment in Greece. A survey was administered to a sample of 60 women that came for fertility treatment in a fertility Centre in Crete. Results show that most patients come from Russia, Italy and the Netherlands and select Greece because of high success rates, positive word of mouth, wide range of treatment options available, ease of travel and the perceived safety of Greece as a country. Sources of information include their doctor, direct communication with a clinic, the internet and word of mouth from past customers or personal sources. The perceived quality of services is high and 75% of respondents believe their treatment was effective and are willing to recommend the Fertility Center to friends/relatives. Also, 55% of respondents combined the fertility treatment with a vacation. Results have implications for the management of businesses that offer medical tourism services and of Greece as a medical tourism destination in terms of targeting, promotion and brand building.