bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Role of Irbesartan in Elevating Serum High Density Lipoprotein in Hypercholesterolemic Animal Model
Authors: Shakir Sabeen , Chaudhry Zunnera Rashid , Atif Maliha , Sadaf Rabia , Chaudhry Erum Rashid , Chaudhry Sana Rasheed 
Published: May 2024

Objective: To explore the HDL cholesterol-raising capacity of Irbesartan (an antihypertensive drug) in rabbit'sserum.Study Design: Laboratory-based experimental study.Place and Duration of Study: The study was carried out at the Animal House of the National Institute of Health(NIH) Islamabad, Pakistan from January 2023 to November 2023.Methods: This study was conducted on 18 rabbits divided into three groups with six rabbits in each. Leaving one group as a normal control, two out of three groups were made hypercholesterolemic by a high-cholesterol diet. Irbesartan was given to one of the hypercholesteremic groups for 30 days. Blood samples were taken for serum analysis of HDL cholesterol.Results: Results of blood serum levels of all three groups were compared and analyzed on three differentoccasions i.e., on day zero, day 120, and day 150 for HDL cholesterol. Their means were calculated using SPSSVersion 20. The irbesartan-treated group showed obvious elevation in serum HDL cholesterol in comparisonwith the hypercholesteremic control group.Conclusion: It is concluded that Irbesartan, an antihypertensive drug has an additional role of elevating serumhigh-density lipoproteins and can provide the supplementary benefit of improving the lipid profile inhypertension and Hypercholesterolemia.
How to cite this: Shakir S, Chaudhry ZR, Atif M, Sadaf R, Chaudhry ER, Chaudhry SR. Novel Role of Irbesartan in Elevating Serum High Density Lipoprotein in Hypercholesterolemic Animal Model. Life and Science. 2024; 5(2): 199-203. doi: http://doi.org/10.37185/LnS.1.1.536
Complications of Therapeutic Plasmapheresis in Patients with Neurologic Diseases at A Tertiary Care Hospital
Authors: Ahmed Naveed , Ahmad Imran , Siddiqi Fuad Ahmad , Nawaz Khurram Haq , Liaqat Jahanzeb , Ahmad Fawad 
Published: May 2024

Objective: To determine the complications of therapeutic plasmapheresis in patients with neurologicaldiseases at a tertiary care hospital.Study Design: Cross-sectional study.Place and Duration of Study: The study was carried out at Department of Neurology, Pak Emirates MilitaryHospital (PEMH) Rawalpindi, Pakistan from August 2021 to July 2022.Methods: This study was carried out on patients diagnosed with various neurologic diseases where therapeuticplasmapheresis was performed which involves the replacement of patient plasma with donor plasma. A totalof 680 therapeutic plasmapheresis treatments were performed on patients with a variety of neurologicdiseases. Ppatients with hemodynamic instability, active sepsis, coagulopathy, and known allergies to freshfrozen plasma were excluded from the study. Data was recorded from consenting patients on a pre-designedproforma recording various parameters.Results: Among 680 treatments,76.2% were carried out in males and 23.8% in females.Guillain Barre Syndrome (42.06%) was the most common disease followed by chronic inflammatorydemyelinating polyneuropathy (13.82%), neuromyelitis optical spectrum disorders (10.29%), and myastheniagravis (7.94%) being the most common ones. In total 157 (23%) adverse events were noted, with fever (2.9%),pruritis (2.8%), urticaria and mild hypotension (2.5% each), tachycardia (2.2%), and DVT (1.3%) beingcommonly encountered complications. Anaphylaxis was recorded in 0.1%. The majority of the reactions weremild 118 (17.3%), some moderate 21 (3%), and few were severe 11 (1.6%). Serious, life-threatening events wereseen in 0.1% and none had a fatal outcome. Prophylactic use of calcium resulted in lower electrolyte imbalancerelatedcomplications.Conclusion: Therapeutic plasmapheresis is a safer treatment option for various neurologic diseases whenperformed by trained staff.
How to cite this: Ahmed N, Ahmad I, Siddiqi FA, Nawaz KH, Liaqat J, Ahmad F. Complications of Therapeutic Plasmapheresis in Patients with Neurologic Diseases at A Tertiary Care Hospital. Life and Science. 2024; 5(2): 259-265. doi: http://doi.org/10.37185/LnS.1.1.538
Evaluación de la Eficacia de los Ejercicios de Risser en Pacientes con Diagnóstico de Pie Plano
Authors: Gutiérrez Nava Miguel Alberto , González Santiago Ana Lilia , García Moreno Irma , García García Nallely , Bustos Ángel de la Cruz , Badillo Michell Serafin , Martínez Cárdenas Karina , López Gómez Rosa Estela 
Published: May 2024

El pie plano se define como la reducción parcial o total del arco longitudinal medio plantar. El objetivo fue evaluar la eficacia de los ejercicios de Risser para aumentar el arco medial del pie plano. método: el estudio es cuasiexperimental donde se manipula la variable independiente que es el factor protector (terapia de Risser), el diseño de los procedimientos de intervención de los ejercicios de Risser fue de 10 sesiones, 3 veces a la semana, con una duración de 10 repeticiones por ejercicio y el análisis estadístico se realizará mediante el software estadístico SPSS en su versión 29.0.0.0, la pruebas que se aplicarán son: la prueba de normalidad, como es una población menor a 50 datos se usa Shapiro-Wilk y la T de Student para muestras relacionadas, comparando la medición inicial de arco de pie derecho e izquierdo, con la medición final de ambos pies. Resultados: Existe una diferencia significativa de medias entre la medición de ambos pies, para el pie derecho es más amplia antes de iniciar la intervención es de 2.5629 cm después de 47.0600 cm (diferencia 14.4971). Conclusión: se recomienda los ejercicios de Risser para aumentar el porcentaje del arco medial del pie en adultos.
Active Galactic Nucleus Properties of ∼1 Million Member Galaxies of Galaxy Groups and Clusters at z < 1.4 Based on the Subaru Hyper Suprime-Cam Survey
Authors: Toba Yoshiki , Hashiguchi Aoi , Ota Naomi , Oguri Masamune , Okabe Nobuhiro , Ueda Yoshihiro , Imanishi Masatoshi , Nishizawa Atsushi J. , Goto Tomotsugu , Hsieh Bau-Ching , Kondo Marie , Koyama Shuhei , Lee Kianhong , Mitsuishi Ikuyuki , Nagao Tohru , Oogi Taira , Sakuta Koki , Schramm Malte , Yanagawa Anri , Yoshimoto Anje 
Published: May 2024

Abstract
Herein, we present the statistical properties of active galactic nuclei (AGNs) for approximately 1 million member galaxies of galaxy groups and clusters with 0.1 < cluster redshift (z
cl) < 1.4 selected using the Subaru Hyper Suprime-Cam, the so-called CAMIRA clusters. In this research, we focused on the AGN power fraction (f
AGN), which is defined as the proportion of the contribution of AGNs to the total infrared (IR) luminosity, L
IR (AGN)/L
IR, and examined how f
AGN depends on (i) z
cl and (ii) the distance from the cluster center. We compiled multiwavelength data using the ultraviolet–mid-IR range. Moreover, we performed spectral energy distribution fits to determine f
AGN using the CIGALE code with the SKIRTOR AGN model. We found that (i) the value of f
AGN in the CAMIRA clusters is positively correlated with z
cl, with the correlation slope being steeper than that for field galaxies, and (ii) f
AGN exhibits a high value at the cluster outskirts. These results indicate that the emergence of the AGN population depends on the redshift and environment and that galaxy groups and clusters at high redshifts are important in AGN evolution. Additionally, we demonstrated that cluster–cluster mergers may enhance AGN activity at the outskirts of particularly massive galaxy clusters. Our findings are consistent with a related study on the CAMIRA clusters that was based on the AGN number fraction.
CEERS: Diversity of Lyα Emitters during the Epoch of Reionization
Authors: Jung Intae , Finkelstein Steven L. , Arrabal Haro Pablo , Dickinson Mark , Ferguson Henry C. , Hutchison Taylor A. , Kartaltepe Jeyhan S. , Larson Rebecca L. , Simons Raymond C. , Papovich Casey , Park Hyunbae , Pentericci Laura , Trump Jonathan R. , Amorín Ricardo O. , Backhaus Bren E. , Bagley Micaela B. , Casey Caitlin M. , Cheng Yingjie , Cleri Nikko J. , Cooper M. C. , Cooper Olivia R. , Gardner Jonathan P. , Gawiser Eric , Grazian Andrea , Hathi Nimish P. , Hirschmann Michaela , Koekemoer Anton M. , Lucas Ray A. , Mobasher Bahram , Pirzkal Nor , Ravindranath Swara , Straughn Amber N. , Yung L. Y. Aaron , de la Vega Alexander 
Published: May 2024

Abstract
We analyze rest-frame ultraviolet to optical spectra of three z ≃ 7.47–7.75 galaxies whose Lyα emission lines were previously detected with Keck/MOSFIRE observations, using the JWST/NIRSpec observations from the Cosmic Evolution Early Release Science survey. From NIRSpec data, we confirm the systemic redshifts of these Lyα emitters, and emission-line ratio diagnostics indicate these galaxies were highly ionized and metal-poor. We investigate Lyα line properties, including the line flux, velocity offset, and spatial extent. For the one galaxy where we have both NIRSpec and MOSFIRE measurements, we find a significant offset in their flux measurements (∼1.3–5× greater in MOSFIRE) and a marginal difference in the velocity shifts. The simplest interpretation is that the Lyα emission is extended and not entirely encompassed by the NIRSpec slit. The cross-dispersion profiles in NIRSpec reveal that Lyα in one galaxy is significantly more extended than the nonresonant emission lines. We also compute the expected sizes of ionized bubbles that can be generated by the Lyα sources and discuss viable scenarios for the creation of sizable ionized bubbles (>1 physical Mpc). The source with the highest-ionization condition is possibly capable of ionizing its own bubble, while the other two do not appear to be capable of ionizing such a large region, but require additional sources of ionizing photons. Therefore, the fact that we detect Lyα from these galaxies suggests diverse scenarios for the escape of Lyα during the epoch of reionization. High-spectral-resolution spectra with JWST/NIRSpec will be extremely useful for constraining the physics of patchy reionization.
Modeling the Saturation of the Bell Instability Using Hybrid Simulations
Authors: Zacharegkas Georgios , Caprioli Damiano , Haggerty Colby , Gupta Siddhartha , Schroer Benedikt 
Published: May 2024

Abstract
The nonresonant streaming instability (Bell instability) plays a pivotal role in the acceleration and confinement of cosmic rays (CRs), yet the exact mechanism responsible for its saturation and the magnitude of the final amplified magnetic field have not been assessed from first principles. Using a survey of hybrid simulations (with kinetic ions and fluid electrons), we study the evolution of the Bell instability as a function of the parameters of the CR population. We find that at saturation, the magnetic pressure in the amplified field is comparable with the initial CR anisotropic pressure, rather than with the CR energy flux, as previously argued. These results provide a predictive prescription for the total magnetic field amplification expected in the many astrophysical environments where the Bell instability is important.
Black Hole–Disk Interactions in Magnetically Arrested Active Galactic Nuclei: General Relativistic Magnetohydrodynamic Simulations Using a Time-dependent, Binary Metric
Authors: Ressler Sean M. , Combi Luciano , Li Xinyu , Ripperda Bart , Yang Huan 
Published: May 2024

Abstract
Perturber objects interacting with supermassive black hole accretion disks are often invoked to explain observed quasiperiodic behavior in active galactic nuclei (AGN). We present global, 3D general relativistic magnetohydrodynamic (GRMHD) simulations of black holes on inclined orbits colliding with magnetically arrested thick AGN disks using a binary black hole spacetime with mass ratio 0.1. We do this by implementing an approximate time-dependent binary black hole metric into the GRMHD Athena++ code. The secondary enhances the unbound mass outflow rate 2–4 times above that provided by the disk in quasiperiodic outbursts, eventually merging into a more continuous outflow at larger distances. We present a simple analytic model that qualitatively agrees well with this result and can be used to extrapolate to unexplored regions of parameter space. We show self-consistently for the first time that spin–orbit coupling between the primary black hole spin and the binary orbital angular momentum causes the accretion disk and jet directions to precess significantly (by 60°–80°) on long timescales (e.g., ∼20 times the binary orbital period). Because this effect may be the only way for thick AGN disks to consistently precess, it could provide strong evidence of a secondary black hole companion if observed in such a system. Besides this new phenomenology, the time-average properties of the disk and accretion rates onto the primary are only marginally altered by the presence of the secondary, consistent with our estimate for a perturbed thick disk. This situation might drastically change in cooled thin disks.
Radial and Vertical Constraints on the Icy Origin of H2CO in the HD 163296 Protoplanetary Disk
Authors: Hernández-Vera Claudio , Guzmán Viviana V. , Artur de la Villarmois Elizabeth , Öberg Karin I. , Cleeves L. Ilsedore , Hogerheijde Michiel R. , Qi Chunhua , Carpenter John , Fayolle Edith C. 
Published: May 2024

Abstract
H2CO is a small organic molecule widely detected in protoplanetary disks. As a precursor to grain-surface formation of CH3OH, H2CO is considered an important precursor of O-bearing organic molecules that are locked in ices. Still, since gas-phase reactions can also form H2CO, there remains an open question on the channels by which organics form in disks, and how much the grain versus the gas pathways impact the overall organic reservoir. We present spectrally and spatially resolved Atacama Large Millimeter/submillimeter Array observations of several ortho- and para-H2CO transitions toward the bright protoplanetary disk around the Herbig Ae star HD 163296. We derive column density, excitation temperature, and ortho-to-para ratio (OPR) radial profiles for H2CO, as well as disk-averaged values of N
T ∼ 4 × 1012 cm−2, T
ex ∼ 20 K, and OPR ∼ 2.7, respectively. We empirically determine the vertical structure of the emission, finding vertical heights of z/r ∼ 0.1. From the profiles, we find a relatively constant OPR ∼ 2.7 with radius, but still consistent with 3.0 among the uncertainties, a secondary increase of N
T in the outer disk, and low T
ex values that decrease with disk radius. Our resulting radial, vertical, and OPR constraints suggest an increased UV penetration beyond the dust millimeter edge, consistent with an icy origin but also with cold gas-phase chemistry. This Herbig disk contrasts previous results for the T Tauri disk, TW Hya, which had a larger contribution from cold gas-phase chemistry. More observations of other sources are needed to disentangle the dominant formation pathway of H2CO in protoplanetary disks.
Relative Occurrence Rate between Hot and Cold Jupiters as an Indicator to Probe Planet Migration
Authors: Gan Tianjun , Guo Kangrou , Liu Beibei , Wang Sharon X. , Mao Shude , Buchner Johannes , Fulton Benjamin J. 
Published: May 2024

Abstract
We propose a second-order statistic parameter ε, the relative occurrence rate between hot Jupiters (HJs) and cold Jupiters (CJs) (ε = η
HJ/η
CJ), to probe the migration of gas giants. Since the planet occurrence rate is the combined outcome of the formation and migration processes, a joint analysis of HJ and CJ frequency may shed light on the dynamical evolution of giant planet systems. We first investigate the behavior of ε as the stellar mass changes observationally. Based on the occurrence rate measurements of HJs (η
HJ) from the Transiting Exoplanet Survey Satellite survey and CJs (η
CJ) from the California Legacy Survey, we find a tentative trend (97% confidence) that ε drops when the stellar mass rises from 0.8 to 1.4 M
⊙, which can be explained by different giant planet growth and disk migration timescales around different stars. We carry out planetesimal and pebble accretion simulations, both of which can reproduce the results of η
HJ, η
CJ, and ε. Our findings indicate that the classical core accretion + disk migration model can explain the observed decreasing trend of ε. We propose two ways to increase the significance of the trend and verify the anticorrelation. Future works are required to better constrain ε, especially for M dwarfs and for more massive stars.
Effect of Cognitive-Behavioral Therapy–Based Anger Management Training on Anger and Aggression Levels of Individuals Convicted of Violent Crimes
Authors: Kayaoğlu Kübra , Köse Mustafa 
Published: May 2024

Purpose
To determine the effect of cognitive-behavioral therapy (CBT)–based anger management training on anger and aggression levels of individuals convicted of violent crimes.

Method
This study was a randomized controlled trial conducted in a prison. Seventy-two individuals who met inclusion criteria were included in the study sample. The experimental group received 10 sessions of CBT–based anger management therapy over a 5-week period.

Results
After CBT–based anger management training, mean total score and mean subdimension scores of the Trait Anger and Anger Expression Style Scale of the experimental group decreased significantly compared to the control group. Similarly, Buss-Perry Aggression Questionnaire total mean score and mean sub-dimension scores of the experimental group significantly decreased compared to the control group.

Conclusion

Results demonstrate that CBT–based anger management training effectively reduces anger and aggression levels among individuals convicted of violent crimes. In this regard, it is recommended that forensic psychiatric–mental health nurses, physicians, and psychologists working in correctional institutions apply CBT–based anger management training. [
Journal of Psychosocial Nursing and Mental Health Services, 62
(10), 51–58.]
The Immunogenomic Landscape of Peripheral High-Dose IL-2 Pharmacodynamics in Patients with Metastatic Renal Cell Carcinoma: A Benchmark for Next-Generation IL-2–Based Immunotherapies
Authors: Beebe Kirk D , Eisner Joel R , Guo John , Shibata Yoichiro , Davison James M , Uronis Josh , Farhangfar Carol , Farhangfar Farhang , Mooney Jill , Milburn Michael V , White Richard L , Amin Asim , Milla Marcos E , Foureau David M 
Published: May 2024

Abstract
High-dose (HD) IL-2 was the first immuno-oncology agent approved for treating advanced renal cell carcinoma and metastatic melanoma, but its use was limited because of substantial toxicities. Multiple next-generation IL-2 agents are being developed to improve tolerability. However, a knowledge gap still exists for the genomic markers that define the target pharmacology for HD IL-2 itself. In this retrospective observational study, we collected PBMC samples from 23 patients with metastatic renal cell carcinoma who were treated with HD IL-2 between 2009 and 2015. We previously reported the results of flow cytometry analyses. In this study, we report the results of our RNA-sequencing immunogenomic survey, which was performed on bulk PBMC samples from immediately before (day 1), during (day 3), and after treatment (day 5) in cycle 1 and/or cycle 2 of the first course of HD IL-2. As part of a detailed analysis of immunogenomic response to HD IL-2 treatment, we analyzed the changes in individual genes and immune gene signatures. By day 3, most lymphoid cell types had transiently decreased, whereas myeloid transcripts increased. Although most genes and/or signatures generally returned to pretreatment expression levels by day 5, certain ones representative of B cell, NK cell, and T cell proliferation and effector functions continued to increase, along with B cell (but not T cell) oligoclonal expansion. Regulatory T cells progressively expanded during and after treatment. They showed strong negative correlation with myeloid effector cells. This detailed RNA-sequencing immunogenomic survey of IL-2 pharmacology complements results of prior flow cytometry analyses. These data provide valuable pharmacological context for assessing PBMC gene expression data from patients dosed with IL-2–related compounds that are currently in development.
Evaluation of Salivary Parameters and Oral Health Status in Periodontally Healthy Subjects and Chronic Periodontitis Subjects
Authors: Kurien Vino Tito V , Shanker Rajesh Kashyap , Hegde Shashikanth , Onisha V , Pillai Siva A S 
Published: May 2024

Introduction:
Periodontal disease is a chronic disease of the oral cavity that consists of a group of inflammatory disorders affecting the supporting structures of the dentition. Saliva can be used to predict the early onset of periodontitis. Several investigations have been carried out to evaluate the salivary chemical compounds that lead to the destruction and/or protection of periodontal tissues. The present study aimed to assess and compare salivary parameters and oral health status in periodontally healthy and chronic generalised periodontitis patients.

Materials and Methods:
This is an in vivo study designed to compare salivary parameters (albumin, urea, total proteins, amylase, glucose and pH) of unstimulated saliva and oral health status of periodontally healthy subjects (n = 65) and chronic generalised periodontitis subjects (n = 65). Human whole unstimulated saliva was collected by spitting method with the subject seated in an upright position after refraining from oral intake for 2 h before saliva collection. Approximately 5 mL of saliva was collected and stored in graduated saliva-collecting vials and refrigerated at 4°C for 1 h. The samples were centrifuged at 2800 rpm for 10 min, and the supernatant was separated from the substrate and stored at 20°C. Next, the sample was defrosted at room temperature and centrifuged at 3000 rpm. The supernatant was separated again to determine the concentrations of glucose, amylase, urea, total protein and albumin using the respective kits and analysed using an automated analyser. Salivary pH was estimated electrometrically with the help of a pH meter.

Results:
A significant association was found between salivary parameters (amylase and albumin total proteins) and clinical parameters (plaque index [PI], gingival index) [GI], probing depth and calculus index in generalised chronic periodontitis subjects when compared to periodontally healthy subjects.

Conclusion:
The increase in salivary parameters (amylase, total proteins and albumin) was statistically significant except for salivary glucose and urea (statistically non-significant) in generalised chronic periodontitis subjects compared to the healthy subjects. As the clinical parameters (probing depth, loss of attachment, PI, GI, calculus index and decay missing filled teeth) in periodontitis subjects increased, the salivary parameters also increased, suggesting a linear relationship between the generalised chronic periodontitis and salivary parameters (total proteins, albumin and amylase).