bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multimodal Migraine Treatment: Does Thermal Feedback Add to the Outcome?
Authors: Sorbi Marjolijn , Tellegen Bert 
Published: August 2010

SYNOPSISThis study was carried out to examine the therapeutic necessity of thermal feedback training in a multimodal treatment program for migraine headache. Twenty‐one patients with frequent (at least two per month) migraine headaches or combined migraine‐tension headaches were randomly assigned to one of two conditions: (1) autogenic relaxation training followed by stress‐coping training; (2) the same treatment package supplemented with thermal feedback.Results indicated the equivalent effectiveness of both treatments in ameliorating headache activity and reducing medication use. These outcomes were stable 7 months after treatment. Between‐group comparisons on clinical improvement and on temperature performance with autogenic relaxation, as well as findings from post‐treatment interviews, led to the conclusion that thermal feedback training can be excluded without weakening the program's therapeutic efficacy.In general the results suggest that thermal feedback per sé does not add to the treatment outcomes obtainable with general relaxation training, and that for patients characterized by high achievement‐motivation and sensitivity to initial failure a feedback regimen might even be counterproductive. Both findings need further experimental clarification.
Patient Motivation in the Treatment of Migraine. A Non‐medicinal Study
Authors: Gallagher R. Michael , Warner Joanne B. 
Published: August 2010

SYNOPSISMotivation is recognized by many physicians as a critical component of any comprehensive treatment program for the migraine patient. To study the role of patient motivation, eighteen migraine patients were entered into a non‐medicinal treatment program to include counselling, biofeedback, stress reduction, dietary restriction, exercise, and sleep pattern adjustment. Patients were divided equally into the following groups: military and civilian flyers who were not permitted maintenance medication to remain on flying status; fertile females who were not practicing birth control; and patients who for various reasons desired no maintenance medication. After six months, the first group (flyers) showed significant improvement in reference to both frequency and duration of headache; the second group (fertile females) showed improvement to a lesser degree; and the third group (varied) showed only minimal improvement. This limited study suggests that patient motivation is a significant determinant in the success of a migraine treatment program.
Migraine Due to Hydrocephalus
Authors: Donaldson I. MacG. 
Published: August 2010

SYNOPSISTwo patients are presented who developed classical migraine in association with raised intracranial pressure due to a colloid cyst of the third ventricle and a presumed brain stem tumor. Although intraventricular tumours have been claimed to occasionally produce migrainous attacks, brain stem and posterior fossa masses have not been regarded as having this potential. Obstructive hydrocephalus was probably the common mechanism and this should be recognized as a rare cause of migraine.
A Comparison of Naproxen Sodium to Propranolol Hydrochloride and a Placebo Control for the Prophylaxis of Migraine Headache
Authors: Sargent Joseph , Solbach Patricia , Damasio Hanna , Baumel Barry , Corbett James , Eisner Larry , Jessen Barbara , Kudrow Lee , Mathew Ninan , Medina Jose , Saper Joel , Vijayan Nazhiyath , Watson Craig , Alger Jeanne 
Published: August 2010

SYNOPSISA 17 week, double‐blind, randomized, parallel, multicenter study compared naproxen sodium 550 mg bid, propranolol hydrochloride 40 mg tid, and placebo in 129 patients with classical or common migraine. Daily efficacy data were collected during the 12 week full treatment phase. Characteristics measured included headache days, headache severity, nausea, vomiting and visual disturbances. Patients and investigators, separately, rated the overall response and tolerance to the medication at the end of the trial.Patients' daily records revealed a trend toward superiority in the reduction of headache frequency, headache severity, nausea and visual disturbances for naproxen sodium and propranolol hydrochloride when compared to the placebo. In the overall evaluation of therapeutic response, both patients and investigators favored naproxen sodium in comparison with placebo. In a similar paired comparison the patients, but not the investigators, judged the overall response to propranolol better than placebo. In the overall evaluation of tolerance, both the patients and investigators favored propranolol hydrochloride. The majority of patients reported a high incidence and severity of gastrointestinal complaints associated with naproxen sodium treatment than propranolol hydrochloride treatment. The incidence and severity of nongastrointestinal complaints related to naproxen and propranolol hydrochloride treatment were comparable.Headache activity occurring before and after the onset of menses was analyzed for a subset of 30 patients. Those treated with naproxen sodium experienced lesser headache frequency and severity during the week prior to menses, compared with the week after onset of menses. The difference in severity in the naproxen sodium treated patients was statistically significant when compared to the placebo treated patients and approached significance when compared to the propranolol hydrochloride treated patients.In this study naproxen sodium was shown to be an effective prophylactic medication for migraine. A long‐term study, to confirm these findings, seems warranted.
Migraine Symptoms in School Children: What Is the Best Diagnostic Characteristic for Migraine?
Authors: Passchier J. , Bonke B. 
Published: August 2010

SYNOPSISMigraine symptoms were assessed in a sample of about 2300 school children between 10 and 17 years of age in Amsterdam. Prevalence of migraine symptoms was very similar to that reported by Waters using the same questionnaire. Headache intensity gave a reliable indication of the presence of other migraine symptoms. This finding was crossvalidated in several subsamples and confirmed the severity hypothesis of Waters for a young population.
Chronic Paroxysmal Hemicrania‐like Headaches in a Child: Response to a Headache Diary
Authors: Klassen Brian D. , Dooley Joseph M. 
Published: August 2010

Chronic paroxysmal hemicrania and cluster headache are both characterized by recurrent, severe, unilateral headaches accompanied by symptoms and signs of autonomic dysfunction. They are differentiated by the frequency, duration, and medication responsiveness of the headaches. Both occur in childhood, although such reports are rare.A 6‐year‐old boy presented with chronic paroxysmal hemicrania‐like headaches. Through the use of a headache diary, his headaches were found to follow stressful events and resolved shortly after the introduction of the diary.Precipitation of chronic paroxysmal hemicrania‐like headaches by stress has not been previously reported. We recommend the use of a headache diary as both an aid to diagnosis and an initial nonpharmacological therapeutic intervention for children with such headaches.
Dracula's Teeth Syndrome
Authors: Jacome Daniel E. 
Published: August 2010

Objective.—To describe a patient with facial pain, ipsilateral facial dystonia, and phantom supernumerary teeth, beginning after resection of hypertrophic gums. She had familial sensorineural deafness.Background.—Atypical cranial dystonia subsequent to dental procedures is associated with facial pain, dysesthesias, or phantom phenomena, but not with phantom supernumerary teeth. Patients with migraine are susceptible to experience cephalic phantom phenomena after dental procedures. Wynne syndrome is a hereditary autosomal dominant disorder characterized by congenital sensorineural deafness and supernumerary teeth.Methods.—Clinical examination, computerized tomography of paranasal sinuses and facial bones, magnetic resonance imaging of the brain, cranial electrophysiological testing, and electroencephalogram.Results.—A 52‐year‐old woman with history of migraine without aura for 40 years exhibited focal right facial involuntary tonic contracture accompanying chronic severe pain over the same area after gum resection. She reported a daily sensation of having two extra upper canine teeth pressing on her tongue, simulating vampire's (“Dracula's”) teeth. She had high‐frequency bilateral sensorineural deafness. Her computerized tomography studies, brain magnetic resonance imaging, and cranial electrophysiological testing were normal.Conclusion.—This patient with chronic migraine had atypical cranial dystonia beginning after a dental procedure. Her dystonia was complicated by the unusual phenomenon of phantom supernumerary teeth. This condition may be misdiagnosed as atypical or psychogenic facial pain when facial dystonia is localized or subtle and is, therefore, confused with an idiosyncratic gesture or habitual spasm. Her signs and symptoms are reminiscent of Wynne syndrome.
Use of the ICHD‐II Criteria in the Diagnosis of Pediatric Migraine
Authors: Hershey Andrew D. , Winner Paul , Kabbouche Marielle A. , Gladstein Jack , Yonker Marcy , Lewis Don , Pearlman Eric , Linder Steven L. , Rothner A. David , Powers Scott W. 
Published: August 2010

Objective.—To evaluate the sensitivity of the new International Classification of Headache Disorders‐2nd edition (ICHD‐II) criteria in the diagnosis of childhood migraine and to propose specific criteria for the diagnosis of childhood migraine.Background.—In 2004, ICHD‐II was adopted by the International Headache Society. The prior version had been criticized for its lack of sensitivity in diagnosing childhood headaches. ICHD‐II is felt to be an improvement as it provides for some differences between pediatric and adult migraine diagnosis in its footnotes, however, has yet to be validated. Clinically, it is the impression of many pediatric headache specialists that children's migraines are of shorter duration, tend to be bilateral rather than unilateral, and that children more often report either photophobia or phonophobia, rather than both.Methods.—The characteristics of headache in 260 patients, ages 18 and under, clinically diagnosed with migraine at two large pediatric headache centers were compiled using standard intake questionnaires. Inter‐rater reliability in clinical diagnosis was determined by consensus of the clinical diagnosis. These data were analyzed applying the International Classification of Headache Disorders‐1st edition (ICHD‐I) and ICHD‐II criteria for migraine to determine sensitivity of migraine diagnosis in comparison with clinical impression. Each headache characteristic in ICHD‐II was analyzed individually to determine its effect on sensitivity of diagnosis.Results.—183/260 patients (70.4%) met ICHD‐I criteria. 161/260 patients (61.9%) met the ICHD‐II criteria with a 4‐ to 72‐hour range. When the footnoted allowance of ICHD‐II for short duration (2 hours) was utilized, 187/260 patients (71.9%) met criteria, while this improved to 192/260 patients (73.9%) with 1‐hour duration. If duration was excluded, 210/260 patients (80.8%) met criteria. The most common reasons for patients not meeting the standard criteria were the requirement of unilateral location, headache duration and number of associated symptoms. Based on these observations, modified criteria were empirically derived and the sensitivity increased to 84.4%. Data were reanalyzed using the criteria of focal head pain, either bilateral or unilateral, shortened duration, and modified associated symptoms, which resulted in an improved sensitivity in migraine diagnosis of 84.4%.Conclusions.—Modification of ICHD‐II criteria to include bilateral headache, headache duration of 1 to 72 hours, and nausea and/or vomiting plus two of five other associated symptoms (photophobia, phonophobia, difficulty thinking, lightheadedness, or fatigue), in addition to the usual description of moderate to severe pain of a throbbing or pulsating nature worsening or limiting physical activity, improved sensitivity of migraine diagnosis to 84.4%.
Serum S100β Protein in Children With Acute Recurrent Headache: A Potentially Useful Marker for Migraine
Authors: Papandreou Ourania , Soldatou Alexandra , Tsitsika Artemis , Kariyannis Catherine , Papandreou Thalia , Zachariadi Asimina , Papassotiriou Ioannis , P. Chrousos George 
Published: August 2010

Objective.—To examine the role of glia‐derived S100β protein and to evaluate its use as a biochemical marker in childhood acute recurrent headache.Methods.—Twenty‐five patients with acute recurrent headache (according to International Headache Society criteria) from our department's Headache Clinic were studied. Blood samples for measurement of serum S100β were drawn: (1) ≤3‐hour post pain attack from our patients and (2) from 23 healthy controls.Results.—Of the 25 patients evaluated, 15 suffered from migraine and 10 from tension‐type headache (TTH). Statistical analysis of the mean values of S100β levels demonstrated a significant elevation in children with migraine headache, with values higher than those of both children with TTH and controls (P= .001).Conclusions.—Our data suggest a direct relation between childhood migraine attacks and increased production of glial S100β protein. Serum S100β determination may be a useful biochemical marker for migraine in acute recurrent headache in childhood.
Tramadol/Acetaminophen for the Treatment of Acute Migraine Pain: Findings of a Randomized, Placebo‐Controlled Trial
Authors: Silberstein Stephen D. , Freitag Frederick G. , Rozen Todd D. , Kudrow David B. , Hewitt David J. , Jordan Donna M. , Fisher Alan C. , Rosenthal Norman R. ,   for the CAPSS‐223 Investigators
Published: August 2010

Objective.—To compare tramadol/acetaminophen (APAP) and placebo for the management of acute migraine pain.Background.—Tramadol/APAP tablets reduced moderate‐to‐moderately severe acute pain in controlled studies of other painful conditions.Methods.—This randomized, double‐blind, placebo‐controlled, parallel group study enrolled adults with migraine pain as per International Headache Society criteria. Subjects took tramadol/APAP (total dose, 75 mg/650 mg) or placebo for a typical migraine with moderate‐to‐severe pain. Severity of pain and migraine‐related symptoms were recorded before study medication and at 0.5, 1, 2, 3, 4, 6, and 24 hours after study medication.Results.—Efficacy analyses included 305 subjects (154 tramadol/APAP and 151 placebo). Treatment response was higher for tramadol/APAP than a placebo at 2 hours after dosing (55.8% vs. 33.8%,P< .001) and at every other assessment from 30 minutes (12.3% vs. 6.6%) through 6 hours (64.9% vs. 37.7%) (allP≤ .022). Subjects in the tramadol/APAP group were more likely than those in the placebo group to be pain‐free at 2 hours (22.1% vs. 9.3%), 6 hours (42.9% vs. 25.2%), and 24 hours (52.7% vs. 37.9%) (allP≤ .007). Two hours after dosing, moderate‐to‐severe symptoms that were less common for tramadol/APAP than placebo included photophobia (34.6% vs. 52.2%,P= .003) and phonophobia (34.3% vs. 44.9%,P= .008), but not migraine‐related nausea (38.5% vs. 29.4%,P= .681). Treatment‐related adverse events included nausea, dizziness, vomiting, and somnolence.Conclusions.—Tramadol/APAP reduces the severity of pain, photophobia, and phonophobia associated with migraine headache, but does not reduce migraine‐associated nausea. Tramadol/APAP might be an appropriate option for the management of moderate‐to‐severe migraine headache.
Development and Validation of the Migraine Screen Questionnaire (MS‐Q)
Authors: Láinez Miguel J.A. , Domínguez Manuel , Rejas Javier , Palacios Gemma , Arriaza Encarnación , Garcia‐Garcia Margarida , Madrigal María 
Published: August 2010

Aim.—To develop and evaluate the clinimetric properties of a new migraine screening questionnaire: the Migraine Screen Questionnaire (MS‐Q).Background.—Migraine is a public health problem requiring screening programs and tools to ensure early detection.Methods.—A questionnaire was developed based on the criteria of the International Headache Society (IHS) and a review of the literature by a committee of experts. Stage I: The original version of the MS‐Q was distributed by mail and completed by Pfizer employees and self‐administered to neurological patients; all subjects were afterward evaluated by a neurologist who was blinded to the MS‐Q results, to establish an independent IHS diagnosis. Stage II: A final version of the MS‐Q was administered to neurological patients to confirm clinimetric properties. Logistic regression and receiver–operator characteristic curve statistical methods were used and the 95% confidence interval, sensitivity, specificity, and positive (PPV) and negative (NPV) predictive values, were estimated.Results.—Of the 605 subjects recruited, 465 were evaluable (325 in stage I and 140 in stage II). Of the original 15 items, 5 conformed the final version of the MS‐Q: frequency and intensity of headache; a duration of between 4 hours and 3 days; nausea; sensitivity to light/noise; and disability. A cutoff point of ≥4 points showed a sensitivity of 0.93 (95% CI = 0.87 to 0.99), specificity of 0.81 (95% CI = 0.72 to 0.91), PPV of 0.83 (95% CI = 0.75 to 0.91), and NPV of 0.92 (95% CI = 0.85 to 0.99). Cronbach's alpha coefficient = 0.82.Conclusions.—The MS‐Q showed adequate validity and reliability, and it could be a good screening tool for application to clinical practice and research.
Stroke‐Related Headache: A Clinical Study in Lacunar Infarction
Authors: Arboix Adrià , García‐Trallero Olivia , García‐Eroles Luis , Massons Joan , Comes Emili , Targa Cecilia 
Published: August 2010

Objective.—To describe the characteristics of headache related to lacunar stroke based on data collected from a prospective hospital‐based stroke registry over a 12‐year period. Demographics, clinical variables, and prognostic features of lacunar stroke in patients with and without headache are compared.Background.—Stroke‐related headache has been largely investigated, but there is little clinical data on headache in individualized stroke subtypes.Methods.—The cohort of 484 patients with lacunar infarction was selected. Forty‐five (9.3%) presented headache within a 72‐hour interval of stroke onset. Predictors of lacunar infarction with headache were assessed by logistic regression analysis.Results.—The intensity of headache was mild in severity and poorly localized (diffuse or bilateral headache). Tension‐type headache was present in 36 patients (80%) and 9 patients (20%) presented nausea or vomiting while experiencing mild pulsating pain. The frequency of headache was 17% in patients with atypical lacunar syndrome, 12% in dysarthria‐clumsy hand, 11.5% in pure sensory stroke, 9.4% in sensorimotor stroke, and 7.1% in pure motor hemiparesis. When patients with lacunar infarction with and without headache were compared, female sex, diabetes mellitus, nausea and vomiting, and mesencephalic topography were significantly more frequent and dysarthria and frequency of symptom free at discharge were less frequent in the headache group. In the multivariate analysis, mesencephalic topography (odds ratio [OR] 16.62), nausea and vomiting (OR 13.27), sex female (OR 2.29), diabetes mellitus (OR 1.96), and age (OR 0.95) were predictors of lacunar infarction with headache.Conclusions.—Headache at the onset of a lacunar infarction is uncommon. Mesencephalic topography, nausea and vomiting, female sex, diabetes, and age were independent variables significantly associated with lacunar infarction with headache. These findings contribute to knowledge of stroke‐related headache in patients with lacunes.
Effects of Noise and a Stressor on Head Pain
Authors: Martin Paul R. , Todd Juanita , Reece John 
Published: August 2010

Objective.—Can causal relationships be established between negative affect (NA) and headaches, and noise (N) and headaches? Do NA and N interact to cause headaches? Do NA and N cause headaches by means of the same or different physiological mechanisms? Are the answers to these questions a function of diagnostic status?Background.—A functional model of chronic headaches has been proposed that seeks to understand the variance in headaches by focusing on the controlling variables, that is, the antecedents and consequences. This study is one in a series investigating the immediate antecedents of headaches, namely the trigger factors.Design.—Twenty‐four subjects with migraine and 44 subjects with tension‐type headache were randomly assigned to one of four experimental conditions defined by the presence or absence of two antecedent challenges, a stressor (S) designed to induce NA and N.Methods.—The S challenge consisted of difficult‐to‐solve anagrams accompanied by failure feedback. The N challenge consisted of 50 dB of white N. Laboratory sessions were divided into adaptation, baseline, challenge, and recovery phases. Responses were measured in terms of headache intensity ratings, forehead electromyographic activity, heart rate, blood pressure, and temporal pulse amplitude (TPA).Results and Conclusions.—Both NA and N precipitated headaches. These two factors did not interact in triggering headaches. Headaches induced by N were associated with elevated TPA but headaches induced by NA were not associated with significant physiological changes. Diagnosis was not related to any of the outcomes.
Intracortical Inhibition and Facilitation in Migraine—A Transcranial Magnetic Stimulation Study
Authors: Siniatchkin Michael , Kröner‐Herwig Birgit , Kocabiyik Ebru , Rothenberger Aribert 
Published: August 2010

Objective.—Migraine is a disease of altered cortical excitability between attacks. However, the mechanisms of abnormal excitability in migraine are insufficiently investigated. Hence, the aim of the study was to investigate intracortical inhibition/facilitation of the motor circuit in migraine.Methods.—Sixteen women suffering from migraine without aura and 15 healthy women were investigated using a suprathreshold transcranial magnetic stimulation (TMS) in the paired‐pulse paradigm with long interstimulus intervals (ISI = 20, 60, 120 ms) and measurement of the cortical silent period.Results.—We found no differences for the cortical silent period and for the long intracortical inhibition between the groups. Concerning intracortical facilitation, this ability was significantly more pronounced in patients suffering from migraine compared with healthy controls.Conclusion.—Migraineurs produce an increased intracortical facilitation. The results may be discussed in line of glutamatergic mechanisms in migraine, which could be related to altered facilitation.