bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Reporting Quality and Risk of Bias of Randomized Controlled Trials
in Traditional Persian Medicine: A Systematic Review
Authors: Norouzi Mojtaba , Haghdoost Ali Akbar , Kkarimiafshar Maryam 
Published: May 2024

Objective::
This study aimed to assess the quality of randomized controlled trials
(RCTs) in the field of Traditional Persian Medicine (TPM) by utilizing specific checklists and
the Cochrane Risk-of-Bias tools (RoB 1.0 and RoB 2.0).

Methods::
RCTs in the field of TPM were analyzed in a systematic review between 2018 and
2022. Quality assessment was performed using CONSORT 2010, CONSORT extensions,
RoB1.0 and RoB 2.0.

Results::
Out of 1112 primary retrieval articles, 139 were eligible for quality assessment. The
mean scores of multi-arm studies and trials of herbal medicine interventions, according to CONSORT
extensions, were 1.47 ± 0.66 and 1.48 ± 0.61 out of 2. Based on RoB 2.0, two-thirds of
the studies were assessed as "high risk" and "some concerns". The highest risk and most concerns
were related to outcome measurement and randomization process, respectively. The lowest
mean score was related to the methods section. Reports on drug and herbal interventions were
insufficient, and the scores of key items, such as randomization implementation and allocation
concealment, were less than one.

Conclusion::
The reporting style of a considerable number of the TPM randomized controlled
trials, especially in methodology, is a point of concern. The utilization and adherence to CONSORT
extensions can be effective in improving the methodological quality of these studies and
enhancing the credibility of the obtained results.
Delayed PTSD Prevalence in Road Traffic Crashes: A Systematic
Review and Meta-analysis
Authors: Salehi-Pourmehr Hanieh , Sabahi Zahra , Pashazadeh Fariba , Tahmasbi Fateme , Aletaha Reza , Kashtkar Mahsa , Farahbakhsh Mostafa , Hajebrahimi Sakineh , Sadeghi-Bazargani Homayoun 
Published: May 2024

Introduction:
This systematic review evaluated the prevalence of delayed posttraumatic
stress disorder (PTSD) following road traffic crashes (RTC).

Materials and Methods:
The sample was RTC survivors, and PTSD was assessed by clinician-
administered measures for at least six months (in line with DSM-V standards).

Results:
The search resulted in 10089 unique records. Fourty-three studies were eligible to
be included in the systematic review. Of these, 29 papers were related to the clinicianadministered
measures, and the rest were on self-reported cases. The total prevalence of
PTSD was 13.5%. Delayed PTSD is common in RTC survivors either 60 months after the
accident. Hospitalized patients were more prone to developing disorders.

Conclusion:
The surveyed countries' demographics demonstrate the differences between
them, necessitating a greater focus on survivors in those countries and financial assistance
for their populations' therapeutic and social needs.
De novo Designing of the Antimicrobial Peptide as a Curative Agent for Methicillin-Resistant Staphylococcus aureus through a Computational Approach
Authors: Sinoliya Priyanka , Solanki Pooran Singh , Niraj Ravi Ranjan Kumar , Sharma Vinay 
Published: May 2024

Background:
The emergence of resistance to multiple drugs has posed a
multitude of difficulties that demand immediate attention and solutions. Multiple drug
resistance arises from the accumulation of numerous genes within a single cell, each
conferring resistance to a specific drug, and from the heightened expression of genes
responsible for multidrug efflux pumps. These pumps effectively expel a diverse array
of drugs from the cell.

Objective:
The multi-drug-resistant organisms, including methicillin-resistant Staphylococcus
aureus, are the hub of numerous diseases, from minute ailments to fatal diseases,
like catheter infections. Nowadays, a combination of many antibiotics is given
together as a multimodality therapy to cure MRSA infections. However, researchers
are exploring novel approaches to find better solutions.

Methods:
De novo designing of the peptide sequences has been done through an in
silico tool. The peptides were further screened using different computational methods.
Following this, the selection was conducted utilizing physicochemical properties as
criteria. Molecular docking of the selected peptide sequence was carried out. Based on
the highest docking score, the model complex was chosen for validation purposes by
conducting studies through molecular dynamics simulations.

Results:
A total of fifty-two novel antimicrobial peptides were designed and evaluated
based on various parameters, targeting MRSA-specific proteins PBP2a and PVL toxin.
Among these designed peptides, the peptide sequence VILRMFYHWAVKTNGP
emerged as the optimal candidate, satisfying all the necessary parameters to be an effective
antimicrobial peptide.

Conclusion:
Molecular docking and MD simulation results showed that the designed
peptide sequence could be the possible solution for MRSA treatment.
Effects of the “AI-TA” Mobile App With Intelligent Design on Psychological and Related Symptoms of Young Survivors of Breast Cancer: Randomized Controlled Trial
Authors: Jiang Lulu , Xu Jiehui , Wu Yanwei , Liu Yanyan , Wang Xiyi , Hu Yun 
Published: May 2024

Background
Young women often face substantial psychological challenges in the initial years following cancer diagnosis, leading to a comparatively lower quality of life than older survivors. While mobile apps have emerged as potential interventions, their effectiveness remains inconclusive due to the diversity in intervention types and variation in follow-up periods. Furthermore, there is a particular dearth of evidence regarding the efficacy of these apps’ intelligent features in addressing psychological distress with these apps.

Objective
This study aims to evaluate the effectiveness of a mobile app with intelligent design called “AI-TA” on cancer-related psychological health and ongoing symptoms with a randomized controlled design.

Methods
Women aged 18 to 45 years diagnosed with breast cancer were randomly assigned to the intervention or control group. The intervention was AI-TA, which included 2-way web-based follow-up every 2 weeks. Both intention-to-treat (ITT) and per-protocol (PP) analyses employed repeated measurement analysis of variance. The participants’ background features, primary outcomes (psychological distress and frequency, self-efficacy, and social support), and secondary outcomes (quality of life) were measured using multiple instruments at 3 time points (baseline, 1-month intervention, and 3-month intervention).

Results
A total of 124 participants were randomly allocated to the control group (n=62, 50%) or intervention group (n=62, 50%). In total, 92.7% (115/124) of the participants completed the intervention. Significant improvements in psychological symptoms (Memorial Symptom Assessment Scale-Short Form) were observed in the ITT group from baseline to 1-month intervention relative to the control group (ITT vs control: 1.17 vs 1.23; P<.001), which persisted at 3-month follow-up (ITT vs control: 0.68 vs 0.91; P<.001). Both the ITT and PP groups exhibited greater improvements in self-efficacy (Cancer Behavior Inventory-Brief Version) than the control group at 1-month (ITT vs PP vs control: 82.83 vs 77.12 vs 65.35; P<.001) and 3-month intervention (ITT vs PP vs control: 92.83 vs 89.30 vs 85.65; P<.001). However, the change in social support (Social Support Rating Scale) did not increase significantly until 3-month intervention (ITT vs control: 50.09 vs 45.10; P=.002) (PP vs control: 49.78 vs 45.10; P<.001). All groups also experienced beneficial effects on quality of life (Functional Assessment of Cancer Therapy-Breast), which persisted at 3-month follow-up (P<.001).

Conclusions
The intelligent mobile app AI-TA incorporating intelligent design shows promise for reducing psychological and cancer-related symptoms among young survivors of breast cancer.

Trial Registration
Chinese Clinical Trial Registry ChiCTR2200058823; https://www.chictr.org.cn/showproj.html?proj=151195
The Effectiveness of Patient Education on Laparoscopic Surgery Postoperative Outcomes to Determine Whether Direct Coaching Is the Best Approach: Systematic Review of Randomized Controlled Trials
Authors: Maheta Bhagvat , Shehabat Mouhamad , Khalil Ramy , Wen Jimmy , Karabala Muhammad , Manhas Priya , Niu Ashley , Goswami Caroline , Frezza Eldo 
Published: May 2024

Background
As of 2022, patient adherence to postoperative guidelines can reduce the risk of complications by up to 52.4% following laparoscopic abdominal surgery. With the availability of various preoperative education interventions (POEIs), understanding which POEI results in improvement in patient outcomes across the procedures is imperative.

Objective
This study aims to determine which POEI could be the most effective on patient outcomes by systematically reviewing all the POEIs reported in the literature.

Methods
In total, 4753 articles investigating various POEIs (eg, videos, presentations, mobile apps, and one-on-one education or coaching) were collected from the PubMed, Embase, and Scopus databases. Inclusion criteria were adult patients undergoing abdominal laparoscopic surgery, randomized controlled trials, and studies that provided postoperative outcomes. Exclusion criteria included studies not published in English and with no outcomes reported. Title and abstract and full-text articles with POEI randomized controlled studies were screened based on the above criteria through a blinded, dual review using Covidence (Veritas Health Innovation). Study quality was assessed through the Cochrane Risk of Bias tool. The included articles were analyzed for educational content, intervention timing, intervention type, and postoperative outcomes appropriate for a particular surgery.

Results
Only 17 studies matched our criteria, with 1831 patients undergoing laparoscopic cholecystectomy, bariatric surgery (gastric bypass and gastric sleeve), and colectomy. In total, 15 studies reported a statistically significant improvement in at least 1 patient postoperative outcome. None of these studies were found to have an overall high risk of bias according to Cochrane standards. In total, 41% (7/17) of the included studies using direct individual education improved outcomes in almost all surgery types, while educational videos had the greatest statistically significant impact for anxiety, nausea, and pain postoperatively (P<.01). Direct group education demonstrated significant improvement in weight, BMI, exercise, and depressive symptoms in 33% (2/6) of the laparoscopic gastric bypass studies.

Conclusions
Direct education (individual or group based) positively impacts postoperative laparoscopic surgery outcomes.

Trial Registration
PROSPERO CRD42023438698; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=438698
Kajian Kearifan Lokal Masyarakat Pesisir Daerah Istimewa Yogyakarta dalam Menghadapi Potensi Multi-Bencana
Authors: Saiddinullah Adji , Saputra Erlis 
Published: May 2024

Abstrak Daerah Istimewa Yogyakarta (DIY) memiliki kompleksitas potensi multi-bencana. Dalam menghadapi kondisi ini, maka identifikasi respons masyarakat dalam wujud kearifan lokal menjadi penting. Penelitian ini bertujuan untuk memahami potensi multi-bencana di wilayah pesisir DIY pada geographical settings yang berbeda, mengeskplorasi kearifan lokal masyarakat pesisir DIY dalam menghadapi potensi multi-bencana, serta menganalisis tingkat pengaplikasian kearifan lokal tersebut pada geographical settings yang berbeda. Pengumpulan data dalam penelitian ini menggunakan triangulasi data yaitu wawancara (wawancara semi terstruktur dan mendalam), observasi lapangan, dan studi literatur. Hasil penelitian ini menunjukkan bahwa perbedaan geographical settings wilayah kepesisiran DIY telah memengaruhi keberagaman potensi multi-bencana di wilayah ini. Masyarakat pesisir DIY memiliki kearifan lokal yang sangat beragam dalam menghadapi potensi multi-bencana. Kearifan lokal ini tumbuh secara intrinsik, ekstrinsik, dan intrinsik-ekstrinsik. Pengaplikasian kearifan lokal secara intrinsik dalam menghadapi potensi multi-bencana di wilayah pesisir DIY dominan memiliki tingkat klasifikasi sedang, sedangkan pengaplikasian kearifan lokal secara ekstrinsik dominan memiliki tingkat klasifikasi tinggi. Abstract The Special Region of Yogyakarta (DIY) has the complexity of multi-disaster potentials. In facing this condition, the identification of community responses in the form of local wisdom becomes crucial. This research aims to understand the multi-disaster potentials in the coastal areas of DIY in different geographical settings, explore the local wisdom of coastal communities in DIY in dealing with multi-disaster potentials, and analyze the level of application of this local wisdom in different geographical settings. Data collection in this research uses data triangulation, namely interviews (semi-structured and in-depth interviews), field observations, and literature studies. The results of this research indicate that the differences in geographical settings in the coastal areas of DIY have influenced the diversity of multi-disaster potentials in this region. Coastal communities in DIY have a highly diverse local wisdom in dealing with multi-disaster potentials. This local wisdom grows intrinsically, extrinsically, and intrinsically-extrinsically. The intrinsic application of local wisdom in dealing with multi-disaster potentials in the coastal areas of DIY predominantly has a moderate classification level, while the extrinsic application of local wisdom predominantly has a high classification level.
Longitudinal Plasma Metabolome Patterns and Relation to Kidney Function and Proteinuria in Pediatric CKD
Authors: Lee Arthur M. , Xu Yunwen , Hu Jian , Xiao Rui , Hooper Stephen R. , Hartung Erum A. , Coresh Josef , Rhee Eugene P. , Vasan Ramachandran S. , Kimmel Paul L. , Warady Bradley A. , Furth Susan L. , Denburg Michelle R. ,   on behalf of the CKD Biomarkers Consortium
Published: May 2024

Key PointsLongitudinal untargeted metabolomics.Children with CKD have a circulating metabolome that changes over time.BackgroundUnderstanding plasma metabolome patterns in relation to changing kidney function in pediatric CKD is important for continued research for identifying novel biomarkers, characterizing biochemical pathophysiology, and developing targeted interventions. There are a limited number of studies of longitudinal metabolomics and virtually none in pediatric CKD.MethodsThe CKD in Children study is a multi-institutional, prospective cohort that enrolled children aged 6 months to 16 years with eGFR 30–90 ml/min per 1.73 m2. Untargeted metabolomics profiling was performed on plasma samples from the baseline, 2-, and 4-year study visits. There were technologic updates in the metabolomic profiling platform used between the baseline and follow-up assays. Statistical approaches were adopted to avoid direct comparison of baseline and follow-up measurements. To identify metabolite associations with eGFR or urine protein-creatinine ratio (UPCR) among all three time points, we applied linear mixed-effects (LME) models. To identify metabolites associated with time, we applied LME models to the 2- and 4-year follow-up data. We applied linear regression analysis to examine associations between change in metabolite level over time (∆level) and change in eGFR (∆eGFR) and UPCR (∆UPCR). We reported significance on the basis of both the false discovery rate (FDR) <0.05 andP< 0.05.ResultsThere were 1156 person-visits (N: baseline=626, 2-year=254, 4-year=276) included. There were 622 metabolites with standardized measurements at all three time points. In LME modeling, 406 and 343 metabolites associated with eGFR and UPCR at FDR <0.05, respectively. Among 530 follow-up person-visits, 158 metabolites showed differences over time at FDR <0.05. For participants with complete data at both follow-up visits (n=123), we report 35 metabolites with ∆level–∆eGFR associations significant at FDR <0.05. There were no metabolites with significant ∆level–∆UPCR associations at FDR <0.05. We report 16 metabolites with ∆level–∆UPCR associations atP< 0.05 and associations with UPCR in LME modeling at FDR <0.05.ConclusionsWe characterized longitudinal plasma metabolomic patterns associated with eGFR and UPCR in a large pediatric CKD population. Many of these metabolite signals have been associated with CKD progression, etiology, and proteinuria in previous CKD Biomarkers Consortium studies. There were also novel metabolite associations with eGFR and proteinuria detected.
Lower incisor position in skeletal Class III malocclusion patients: a comparative study of orthodontic camouflage and orthognathic surgery
Authors: Liu Hao , Zhang Yuning , Lu Wenhsuan , Yang Yuhui , Liu Xiaomo , Chen Si , Li Weiran , Han Bing 
Published: May 2024

ABSTRACT

Objectives
To determine the difference between orthodontic camouflage and orthodontic-orthognathic surgery using the traditional cephalometric measurement IMPA and the newly proposed IA/PAMD, the angle between the long axis of the lower incisor (IA) and the principal axis of the mandibular alveolus (PAMD).

Materials and Methods
This study included 40 cases each in the orthodontic camouflage group (OG) and orthodontic-orthognathic surgery group (SG). The differences between the IMPA and IA/PAMD before and after treatment were compared between the two groups. T0 lateral cephalometric images of the 10 cases with the highest and lowest increase in the IA/PAMD were analyzed to identify characteristics associated with a higher risk of overdecompensation of the lower incisors during presurgical orthodontic treatment.

Results
Both the OG and SG showed a significant improvement in hard- and soft-tissue measurements. However, in the OG, there was significant lingual inclination of the lower incisor but only a small change in the IA/PAMD. In the surgical group, the IMPA was close to 90° after treatment, but the IA/PAMD significantly increased.

Conclusions
In orthodontic camouflage, the lower anterior teeth were significantly moved lingually with a better root-bone relationship. However, this relationship deteriorated in some surgical patients. Therefore, it is important to conduct cephalometric or cone-beam computed tomography examinations during preoperative orthodontics to identify and prevent possible periodontal risks.
Intensifikasi Budidaya Perikanan (Osphronemus Gouramy) Mandiri Berbasis Sumberdaya Lokal sebagai Upaya Peningkatan Produktivitas POKDAKAN Mina Sida Karya
Authors: Bimantara Arif , Zuhdi M. Nurdin , Tunggali Ade Putranto Prasetyo Wijiharto , Manasikana Rinta Arina 
Published: May 2024

Mina Sida Karya Fish Cultivation Group (POKDAKAN) operates in Sidamulih Village, Rawalo District, Banyumas Regency, Central Java, employing an extensive, traditional fish farming system that yields low productivity. This group faces four significant challenges that necessitate attention: (1) Insufficient knowledge and skills among partners in intensive gourami fish farming management to enhance POKDAKAN Mina Sida Karya's productivity; (2) Lack of a consistent water supply for cultivation throughout the year; (3) Limited knowledge in producing cost-effective natural and artificial feed; (4) Inadequate expertise in marketing partner products, resulting in a restricted market reach. Addressing these challenges, service activities have been implemented using Participatory Learning and Action (PLA). These include (1) providing assistance and training in intensive gourami fish farming management to boost cultivation productivity; (2) drilling boreholes up to 75 meters deep to secure a year-round water source; (3) conducting training sessions on independent feed production, both artificial and natural Daphnia sp., enabling partners to generate their own feed; (4) establishing digital branding systems through social media platforms to expand market presence. This aims to increase the productivity of the Mina Sida Karya Fish Farming Group. The activities that have been carried out have significantly impacted the Mina Sida Karya POKDAKAN with a percentage of 57.14% of participants stating that they have sufficient knowledge about intensive osphronemus gouramy fish farming, 61.90% stating that they have no difficulty in obtaining water supply, 52.38% stating that they know how to produce efficient and cost-effective natural feed, and 66.67% stating that they are satisfied with the market reach of fish products.
Mental Illness - An Illness to Well-Being Towards Children: Reference to socio-political violence in literature
Authors: S Sri Sakuntala , Srinivas Sarakanam , Murthy D. Sudarsana , Gadre Monika , Masih Jolly 
Published: May 2024

This research paper explores the adverse impact of socio-political turmoil that has long been in existence in Assam society on the psyche of children with reference to Aruni Kashyap's The House with a Thousand Stories.
This research aims to identify and understand the various psychological issues that children are subject to in a society when it is afflicted with socio-political turmoil and its consequent violence unleashed on people due to the armed struggle of the ULFA and the repressive administration of the state. The objectives of this research are (i) to study the characterization of Mamoni and Mridul, (ii) to understand and analyse the impact of socio-political turmoil on the psyche of children with reference to the above-chosen characters, (iii) to explore the connectivity between the narrative and the author’s political inclination in the novel, and (iv) to understand how objectively the historical incidents were reflected in the novel. The research is carried out by studying the chosen primary source against the pragmatic concepts of psychologists, journalists, social activists, and significant historical facts that appeared in reliable data sources such as journals, web studies, newspapers, and other publications. In conclusion, this research sheds light on the profound psychological repercussions experienced by children in Assam society amidst socio-political turmoil, as exemplified in Aruni Kashyap's "The House with a Thousand Stories." By delving into the characters of Mamoni and Mridul, analyzing the intricate interplay between narrative and political inclinations, and objectively examining historical incidents reflected in the novel, this study not only enhances our comprehension of the multifaceted impact on the psyche of children but also contributes valuable insights for policymakers, educators, and communities striving to address and mitigate the enduring consequences of such tumultuous environments on the younger generation.