bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interprofessional follow-up of patients with cancer in France (the SINPATIC study): a preliminary, qualitative study of the patient’s perspective
Authors: Mirat William , Moscova Laura , Lustman Matthieu , Dawidowicz Sebastien , Picot Genevieve , Lebel Audrey , Cittée Jacques , Ferrat Emilie 
Published: May 2024

Abstract

Background
In 2020, 19.2 million people were diagnosed with cancer, and nearly 10 million cancer patients died worldwide. An effective cancer care pathway must be based on coordination, multidisciplinarity, a personalized approach, and collaboration between stakeholders. Follow-up can be improved by good collaboration and communication between GPs and the cancer care team at a common level of organization.

Objectives
To study patients with solid cancers and assess their perceptions of the care pathway, the roles of the healthcare professionals involved, and interprofessional collaboration.

Methods
In a preliminary, qualitative study (part of the SINPATIC study of general practitioners, oncologists, nurses, and patients), adult patients with cancer in the Paris area of France were interviewed between January and April 2018. Using purposive sampling, 10 patients were recruited from hospital departments and primary care. An interview guide explored 3 themes: the care pathway, the stakeholders’ roles in follow-up, and interprofessional collaboration.

Results
For patients, dealing with cancer is a complex process of awareness, care provision, decision-making, task assignment, a lack of clarification of professional roles, a piecemeal announcement of the diagnosis of cancer by several stakeholders, organizational and administrative difficulties, non-formal collaboration in inertia (tending towards collaboration under construction), and with cancer follow-up that was usually parallel, sometimes shared, rarely sequential.

Conclusion
This SINPATIC substudy provided us a better understanding of the complexity of the patient care pathway. Looking forward, the present findings might stimulate thoughts on the design and development of interventional studies.
Need to Revise Classification of Physical Activity Intensity in Older Adults? The Use of Estimated METs, Measured METs, and V̇O2 Reserve
Authors: Skjødt Mathias , Tully Mark A , Tsai Li-Tang , Gejl Kasper Degn , Ørtenblad Niels , Jensen Kurt , Koster Annemarie , Visser Marjolein , Andersen Marianne Skovsager , Caserotti Paolo 
Published: May 2024

Abstract

Background
Multiples of resting metabolic rate (RMR) are often used to classify physical activity intensity, a concept known as the metabolic equivalent of task (MET). However, the METs metrics may misclassify physical activity intensity in older adults because of age-related changes in RMR and maximal aerobic capacity (V˙O2max). This study aimed to (i) compare classifications of activity intensity by estimated (METsestimated) and measured (METsmeasured) METs and (ii) compare physical activity classified by absolute (METsmeasured) versus relative intensity (%V˙O2Reserve) in older adults.

Methods
Ninety-eight adults aged 75–90 years participated in the study. RMR and V˙O2 during sitting, standing, daily activities, and 6-minute walking test were measured. V˙O2Reserve was defined as the difference between V˙O2max and RMR. Moderate and vigorous intensity was classified as 3 and 6 METs and 40% and 60% of V˙O2Reserve, respectively. Paired t tests and a confusion matrix were used to investigate aims 1 and 2, respectively.

Results
METsmeasured was 24% lower than the standard 1 MET of 3.5 mL O2·min−1·kg−1. METsestimated underestimated the intensity during daily and walking activities when compared to METsmeasured. Nevertheless, when comparing METsmeasured to percentages of V˙O2Reserve, a mismatch was shown for moderate intensity in 47%–67% of the participants during daily activities and 21% of the participants during self-selected gait speed.

Conclusions
Applying METsestimated for older adults leads to potential underestimation of physical activity intensity, suggesting that current classification metrics should be revised for older adults. V˙O2Reserve is a candidate metric for establishing precise physical activity intensity cut points for older adults.
Clinical Trials Registration Number: NCT04821713
Numerical modelling of earthquake sequences involving valving and pumping of fluids
Authors: Marguin Valentin , Simpson Guy 
Published: May 2024

SUMMARYFaults in the upper crust are sometimes thought to act as self-sealing valves, episodically releasing highly overpressured fluids trapped at greater depth during earthquakes. They are also often considered to be capable of actively pumping fluids into or out of faults in response to coseismic volumetric strain, thermal pressurization or other mechanisms. In this study, we investigate how these different types of behaviour (i.e. valve versus pump) are manifested in earthquakes. We do this using a 2-D plane strain model where frictional sliding on a thrust fault that is fed by a fluid source at its base is coupled to porous flow, thermal pressurization and strong variations in permeability. Our results show that thermal pressurization leads to dramatic dynamic weakening that produces earthquakes that propagate as slip pulses producing large stress drop, large slip and high slip velocities. On the other hand, valve-type behaviour typically produces smaller, less energetic earthquakes that commonly arrest before rupturing the entire fault. In some valve models, we observe complex compound ruptures and swarm activity, which is linked to the ascent of a propagating fluid pressure pulse driven by a large increase in permeability during sliding. Both pump and valve mechanisms can produce anomalously weak faults, though they are each associated with distinctly different fluid pressure and strength evolution over the seismic cycle and during rupture. Our models highlight the complex way in which fluids may interact with earthquakes, especially if valve and pump models coexist.
Across Commas, Across Semicolons, Across Oceans: Presentation Style and Immigrant Dictionaries
Authors: Vrbinc Alenka , Farina Donna M T Cr , Vrbinc Marjeta 
Published: May 2024

Abstract
It is unfortunate that scholars have given scant attention to what can be called immigrant dictionaries. These books are significant to the history of (learner) lexicography; they meet pressing needs of immigrants and refugees. This article examines four immigrant dictionaries, Slovenian–English and English–Slovenian (Kubelka 1904, Kubelka 1912b, Košutnik 1912, and Kern 1919), published in the early twentieth century at a time when the Slovenian immigration to the United States was at its height. The presentation of information in these dictionaries is investigated with a focus on the treatment of homonymy, polysemy, conversion, and parenthetical information. Findings address the implications of a macrostructure-oriented versus a microstructure-oriented approach for immigrant user understanding. The paper recommends that learner lexicography should prioritize the design of the lexicographic presentation in the microstructure and prioritize the presentation of meaning over other possible elements covered traditionally in dictionaries.
Fall armyworm (Lepidoptera: Noctuidae): practical resistance of 2 Brazilian populations to Cry1A.105 + Cry2Ab and Cry1F Bt maize
Authors: Orozco-Restrepo Silvana M , Santos-Amaya Oscar F , Miranda Morgana de Souza , Tavares Clébson S , Pereira Eliseu José G 
Published: May 2024

Abstract
In the Americas, transgenic crops producing insecticidal proteins from Bacillus thuringiensis Berliner (Bt, Bacillales: Bacillaceae) have been used widely to manage fall armyworm (FAW, Spodoptera frugiperda [J.E. Smith]). As resistance to Cry1 single-gene Bt maize (Zea mays L.) rapidly evolved in some FAW populations, pyramided Bt maize hybrids producing Cry1, Cry2, or Vip3Aa proteins were introduced in the 2010s. We examined field-evolved resistance to single- and dual-protein Bt maize hybrids in 2 locations in southeastern Brazil, where plant damage by FAW larvae far exceeded the economic threshold in 2017. We collected late-instar larvae in Cry1A.105 + Cry2Ab and Cry1F maize fields and established 2 FAW populations in the laboratory. The F1 offspring reared on the foliage of Bt and non-Bt maize plants (Cry1A.105 + Cry2Ab and Cry1F) showed neonate-to-adult survival rates as high as 70% for both populations. There was no significant difference in the life-table parameters of armyworms reared on non-Bt and Bt maize foliage, indicating complete resistance to Cry1A.105 + Cry2Ab maize. Larval survival rates of reciprocal crosses of a susceptible laboratory strain and the field-collected populations indicated nonrecessive resistance to Cry1F and a recessive resistance to Cry1A.105 + Cry2Ab maize. When relaxing the selection pressure, the armyworm fitness varied on Cry1A.105 + Cry2Ab and non-Bt maize; the resistance was somewhat stable across 12 generations, without strong fitness costs, although one of the lines died confounded by a depleted-quality, artificial rearing diet. To our knowledge, this is the first report documenting the practical resistance of FAW to a pyramided Bt crop. We discuss the implications for resistance management.
Precision medicine for pancreatic cancer: characterizing the clinicogenomic landscape and outcomes of KRAS G12C-mutated disease
Authors: Keane Fergus , Chou Joanne F , Walch Henry , Schoenfeld Joshua , Singhal Anupriya , Cowzer Darren , Harrold Emily , O’Connor Catherine A , Park Wungki , Varghese Anna , El Dika Imane , Balogun Fiyinfolu , Yu Kenneth H , Capanu Marinela , Schultz Nikolaus , Yaeger Rona , O’Reilly Eileen M 
Published: May 2024

Abstract

Background
Mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) is the most common oncogene alteration in pancreatic ductal adenocarcinoma, and KRAS glycine to cystine substitution at codon 12 (G12C) mutations (KRAS G12Cmut) are observed in 1%-2%. Several inhibitors of KRAS G12C have recently demonstrated promise in solid tumors, including pancreatic cancer. Little is known regarding clinical, genomics, and outcome data of this population.

Methods
Patients with pancreatic cancer and KRAS G12Cmut were identified at Memorial Sloan Kettering Cancer Center and via the American Association of Cancer Research Project Genomics, Evidence, Neoplasia, Information, Exchange database. Clinical, treatment, genomic, and outcomes data were analyzed. A cohort of patients at Memorial Sloan Kettering Cancer Center with non-G12C KRAS pancreatic cancer was included for comparison.

Results
Among 3571 patients with pancreatic ductal adenocarcinoma, 39 (1.1%) with KRAS G12Cmut were identified. Median age was 67 years, and 56% were female. Median body mass index was 29.2 kg/m2, and 67% had a smoking history. Median overall survival was 13 months (95% CI: 9.4 months, not reached) for stage IV and 26 months (95% CI: 23 months, not reached) for stage I-III. Complete genomic data (via American Association of Cancer Research Project Genomics, Evidence, Neoplasia, Information, Exchange database) was available for 74 patients. Most common co-alterations included TP53 (73%), CDKN2A (33%), SMAD4 (28%), and ARID1A (21%). Compared with a large cohort (n = 2931) of non-G12C KRAS-mutated pancreatic ductal adenocarcinoma, ARID1A co-mutations were more frequent in KRAS G12Cmut (P &lt; .05). Overall survival did not differ between KRAS G12Cmut and non-G12C KRAS pancreatic ductal adenocarcinoma. Germline pathogenic variants were identified in 17% of patients; 2 patients received KRAS G12C-directed therapy.

Conclusion
Pancreatic cancer and KRAS G12Cmut may be associated with a distinct clinical phenotype. Genomic features are similar to non-G12C KRAS-mutated pancreatic cancer, although enrichment of ARID1A co-mutations was observed. Targeting of KRAS G12C in pancreatic cancer provides a precedent for broader KRAS targeting in pancreatic cancer.
Identification of TP53 germline variants in pediatric patients undergoing tumor testing: strategy and prevalence
Authors: Luo Minjie , Wong Derek , Zelley Kristin , Wu Jinhua , Schubert Jeffery , Denenberg Elizabeth H , Fanning Elizabeth A , Chen Jiani , Gallo Daniel , Golenberg Netta , Patel Maha , Conlin Laura K , Maxwell Kara N , Wertheim Gerald B , Surrey Lea F , Zhong Yiming , Brodeur Garrett M , MacFarland Suzanne P , Li Marilyn M 
Published: May 2024

Abstract

Background
TP53 alterations are common in certain pediatric cancers, making identification of putative germline variants through tumor genomic profiling crucial for disease management.

Methods
We analyzed TP53 alterations in 3123 tumors from 2788 pediatric patients sequenced using tumor-only or tumor-normal paired panels. Germline confirmatory testing was performed when indicated. Somatic and germline variants were classified based on published guidelines.

Results
In 248 tumors from 222 patients, 284 tier 1/2 TP53 sequence and small copy number variants were detected. Following germline classification, 86.6% of 142 unique variants were pathogenic or likely pathogenic. Confirmatory testing on 118 patients revealed germline TP53 variants in 28 of them (23 pathogenic or likely pathogenic and 5 of uncertain significance), suggesting a minimum Li-Fraumeni syndrome incidence of 0.8% (23/2788) in this cohort, 10.4% (23/222) in patients with TP53 variant–carrying tumors, and 19.5% (23/118) with available normal samples. About 25% (7/28) of patients with germline TP53 variants did not meet Li-Fraumeni syndrome diagnostic or testing criteria, while 20.9% (28/134) with confirmed or inferred somatic origins did. TP53 biallelic inactivation occurred in 75% of germline carrier tumors and was also prevalent in other groups, causing an elevated tumor-observed variant allelic fraction. Somatic evidence, however, including low variant allele fraction correctly identified only 27.8% (25/90) of patients with confirmed somatic TP53 variants.

Conclusion
The high incidence and variable phenotype of Li-Fraumeni syndrome in this cohort highlights the importance of assessing germline status of TP53 variants identified in all pediatric tumors. Without clear somatic evidence, distinguishing somatic from germline origins is challenging. Classifying germline and somatic variants should follow appropriate guidelines.
Removal of a large symptomatic retrocardiac mediastinal lipoma
Authors: Wollheim Martina , Willatt Lily F S , Ehrsam Jonas P , Cerncic Priska , Lachat Mario L , Schöb Othmar , Inci Ilhan 
Published: May 2024

Abstract
Large mediastinal lipomas are rare. Complete surgical resection can be difficult due to the intricate anatomy in the mediastinum. We report the case of a 75-year-old man with worsened retrosternal pressure, decline in performance and syncope episodes. Computed tomography revealed a large retrocardiac low-attenuated mediastinal lesion measuring 10 × 8 cm, compressing the left atrium and pulmonary veins bilaterally. Surgical exploration was achieved through a right anterolateral thoracotomy with a successful en bloc resection without any intraoperative complications. The total operation time was 185 min with a total blood loss of &lt;250 ml. Stand-by extracorporeal life support was present throughout the procedure, but its use was not required. The postoperative course was uneventful. The pathological examination revealed a mature mediastinal lipoma without any evidence of malignancy. In the 12-month control the patient was completely free of symptoms and in a good general condition.
Gastrointestinal basidiobolomycosis: a rare manifestation of Basidiobolus ranarum in a non-endemic region
Authors: Fathaddin Amany , Alobaid Sarah , Alhumoudi Duaa , Almarshoud Ghaida , Alsubaie Abdulaziz , Alotaibi Naif H 
Published: May 2024

Abstract
Gastrointestinal basidiobolomycosis (GIB) is a rare fungal infection caused by the Basidiobolus ranarum, and it possesses a significant challenge to diagnose it as it presents with non-specific symptoms that often mimic cancer. Herein, we report a case of GIB in a 51-year-old male from the central region of Saudi Arabia, a non-endemic region of GIB, which was initially misdiagnosed as colon cancer. A 51-year-old man presented with abdominal pain for two-months, non-bloody diarrhea, loss of appetite, and weight loss. Abdominal examination revealed a large mass measuring ~10x15cm. Radiological findings prompted the diagnosis of a colon mass, and the patient was surgically treated under that impression. Hemicolectomy and end colostomy with mucous fistula from distal sigmoid stump were done. Histopathology was consistent with GIB. The diagnosis of GIB presents a serious challenge and requires a high index of clinical suspicion.
An unusual presentation of penile fracture with complete transection of urethra: a case report
Authors: Dunna Vasanth , Giduturi Srinivasa Rao , Chary K S N , Kutikuppala L V Simhachalam , Jose Anna Mary , Golla Varshitha 
Published: May 2024

Abstract
Penile fracture is one such urologic emergency that occurs when the penis is struck bluntly during sexual activity, and in less than 5–10% of cases, the concurrent urethral damage is evident, but complete transection is very rare. A 37-year-old male presented with a history of ‘snap’ sound and immediate detumescence of penis during intercourse, when he fell and hit the pubic bone of his partner. There was acute retention of urine, an attempt to pass a catheter failed and the patient underwent supra-pubic catheterization. On examination, there was classical ‘eggplant deformity’ of the penis with blood at the tip of the meatus. MRI showed a tunical tear on both sides at the penoscrotal junction with indistinct urethra and extensive hematoma in the proximal penile shaft. Surgical management was successfully done by anastomotic urethroplasty and cavernosal repair.
Theoretical investigation of energy levels and transitions for Ce iii with applications to kilonova spectra
Authors: Gaigalas G , Rynkun P , Domoto N , Tanaka M , Kato D , Kitovienė L 
Published: May 2024

ABSTRACT
Doubly ionized cerium (Ce2+) is one of the most important ions to understand the kilonova spectra. In particular, near-infrared (NIR) transitions of Ce iii between the ground (5p6 4f2) and first excited (5p6 4f 5d) configurations are responsible for the absorption features around 14 500 Å. However, there is no dedicated theoretical studies to provide accurate transition probabilities for these transitions. We present energy levels of the ground and first excited configurations and transition data between them for Ce iii. Calculations are performed using the grasp2018 package, which is based on the multiconfiguration Dirac–Hartree–Fock and relativistic configuration interaction methods. Compared with the energy levels in the NIST data base (Kramida et al. 2024), our calculations reach the accuracy with the root-mean-square (rms) of 2732 or 1404 cm−1 (excluding one highest level) for ground configuration, and rms of 618 cm−1 for the first excited configuration. We extensively study the line strengths and find that the Babushkin gauge provides the more accurate values. By using the calculated gf values, we show that the NIR spectral features of kilonova can be explained by the Ce iii lines.
Unveiling the X-ray polarimetric properties of LMC X−3 with IXPE, NICER, and Swift/XRT
Authors: Garg Akash , Rawat Divya , Méndez Mariano 
Published: May 2024

ABSTRACT
The incoming Imaging X-ray Polarimetry Explorer (IXPE) observations of X-ray binaries provide a new tool to investigate the underlying accretion geometry. Here, we report the first measurements of X-ray polarization of the extragalactic black-hole X-ray binary LMC X−3. We find a polarization fraction of $\sim 3~{{\ \rm per\ cent}}$ at a polarization angle of ∼135° in the 2–8 keV energy band with statistical significance at the 7σ level. This polarization measurement significantly exceeds the minimum detectable polarization threshold of 1.2 per cent for the source, ascertained at a 99 per cent confidence level within the 2–8 keV energy band. The simultaneous spectro-polarimetric fitting of Neutron Star Interior Composition Explorer, Swift/X-Ray Telescope (XRT), and IXPE revealed the presence of a disc with a temperature of ∼1 keV and a Comptonized component with a power-law index of ∼2.4, confirming the soft nature of the source. The polarization degree increases with energy from ∼3 per cent in the 2–5.7 keV band to ∼9 per cent in the 5.7–8 keV band, while the polarization angle is energy independent. The observed energy dependence and the sudden jump of polarization fraction above 5 keV supports the idea of a static slab coronal geometry for the Comptonizing medium of LMC X−3.
Second Time's the Charm? Assessing the Sensitivity and Yield of Inpatient Diagnostic Algorithms for Pulmonary Tuberculosis in a Low-Prevalence Setting
Authors: Dugdale Caitlin M , Zachary Kimon C , McEvoy Dustin S , Branda John A , Courtney Amy , Craig Rebecca , Doms Alexandra , Germaine Lindsay , Green Chloe V , Gulbas Eren , Hooper David C , Hurtado Rocio M , Hyle Emily P , Jerry Michelle S , Lazarus Jacob E , Paras Molly , Turbett Sarah E , Shenoy Erica S 
Published: May 2024

AbstractBackgroundFor persons with suspected pulmonary tuberculosis, the guidelines of the Centers for Disease Control and Prevention recommend collecting 3 respiratory specimens 8 to 24 hours apart for acid-fast bacilli (AFB) smear and culture, in addition to 1 nucleic acid amplification test (NAAT). However, data supporting this approach are limited. Our objective was to estimate the performance of 1, 2, or 3 AFB smears with or without NAATs to detect pulmonary tuberculosis in a low-prevalence setting.MethodsWe conducted a retrospective study of hospitalized persons at 8 Massachusetts acute care facilities who underwent mycobacterial culture on 1 or more respiratory specimens between July 2016 and December 2022. We evaluated percentage positivity and yield on serial AFB smears and NAATs among people with growth of Mycobacterium tuberculosis on mycobacterial cultures.ResultsAmong 104 participants with culture-confirmed pulmonary tuberculosis, the first AFB smear was positive in 41 cases (39%). A second AFB smear was positive in 11 (22%) of the 49 cases in which it was performed. No third AFB smears were positive following 2 initial negative smears. Of 52 smear-negative cases, 36 had a NAAT performed, leading to 23 additional diagnoses. Overall sensitivity to detect tuberculosis prior to culture positivity was higher in any strategy involving 1 or 2 NAATs (74%–79%), even without AFB smears, as compared with 3 smears alone (60%).ConclusionsTuberculosis diagnostic testing with 2 AFB smears offered the same yield as 3 AFB smears while potentially reducing laboratory burden and duration of airborne infection isolation. Use of 1 or 2 NAATs increased sensitivity to detect culture-positive pulmonary tuberculosis when added to AFB smear–based diagnostic testing alone.