bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Challenging Oncologic Cases: A Comparative Analysis Between ChatGPT, Gemini, and a Multidisciplinary Tumor Board
Authors: Hernández‐Flores Luis A. , López‐Martínez José B. , Rosales‐de‐la‐Rosa Jesús J. , Aillaud‐De‐Uriarte Daniel , Contreras‐Garduño Sergio , Cortés‐González Rubén 
Published: February 2025

ABSTRACTIntroductionSince its introduction in 2022, public‐access conversational AI, exemplified by ChatGPT and Gemini, has been increasingly utilized in medical decision‐making, though its impact is questionable. This study aims to evaluate its efficacy in assessing complex oncologic cases compared to a multidisciplinary tumor board (MTB) comprising experts from various specialties.MethodsA 2‐year retrospective analysis was conducted on 98 oncological cases at a reference medical center in Mexico City. A MTB comprising surgical oncologists, medical oncologists, radio‐oncologists, pathologists, among others, reviewed and discussed each case to determine management strategies. We evaluated four key decision points, dichotomized as either affirmative or negative: the need for new imaging studies, radiation therapy, chemotherapy, and surgery. Comprehensive medical documentation accompanied each case. We then compared AI's decisions with those of the MTB using the same criteria and conducted a Cohen's Kappa test to assess agreement.ResultsAgreement between ChatGPT (4o) and Gemini (1.5 Flash), and the MTB ranged from none to slight for additional imaging studies (Gemini: κ = 0.100, p = 0.087; ChatGPT 4o: κ = 0.024, p = 0.592) and chemotherapy (Gemini: κ = 0.089, p = 0.316; ChatGPT 4o: κ = 0.336, p = 0.001). Moderate agreement was observed for decisions regarding surgery (Gemini: κ = 0.194, p = 0.046; ChatGPT 4o: κ = 0.467, p = < 0.001) and radiotherapy (Gemini: κ = 0.214, p = 0.012; ChatGPT 4o: κ = 0.525, p = < 0.001).ConclusionsBoth ChatGPT and Gemini showed moderate agreement with the multidisciplinary tumor board on decisions regarding surgery and radiotherapy. ChatGPT also showed moderate agreement in chemotherapy, but further assessment is needed for other interventions. ChatGPT proved to be superior to Gemini in most key points. The potential of these public access AI in oncology warrants continued exploration to refine its utility in clinical practice.
Reaction Kinetics of NH2 With H2CO and CH3CHO: Modeling Implications for NH3‐Dual Fuel Blends
Authors: Shrestha Krishna Prasad , Mai Tam V.‐T. , Giri Sushant , Reddy V. Mahendra , Szőri Milán , Verma Rakhi , Mauss Fabian , Giri Binod Raj , Huynh Lam Kim 
Published: February 2025

ABSTRACTCarbon‐free fuels like ammonia (NH3) and hydrogen (H₂) offer significant potential in combating global warming by reducing greenhouse gas emissions and moving toward zero carbon emissions. Over the past few years, our research has focused on understanding the combustion behavior of carbon‐neutral and carbon‐free fuels. In particular, we have explored the combustion characteristics of NH3 when blended with various hydrocarbons and oxygenates. Our investigation revealed that carbon‐nitrogen cross‐chemistry plays a crucial role in shaping the combustion properties of NH3‐hydrocarbon/oxygenate blends. Specifically, the chemistry of amino (NH2) radicals is vital in influencing the low‐temperature reactivity of these blends. Understanding the interactions between carbon and nitrogen is essential for optimizing combustion processes and improving the emissions profile of NH3‐based fuels. Recognizing the significance of this cross‐chemistry, we investigated the reaction kinetics of NH2 radicals with formaldehyde (H2CO) and acetaldehyde (CH3CHO) using high‐level ab initio and transition state theory calculations. We computed the potential energy profiles of these reactions at the CCSD(T)/CBS//M06‐2X/aug‐cc‐pVTZ level of theory to analyze the reactivity of NH2 radicals at various C─H bond sites. The newly derived rate constants have proven to be highly sensitive for modeling the low‐temperature oxidation of NH3‐dual fuel blends, significantly enhancing the predictive accuracy of our previously published kinetic models. This work offers valuable insights into the role of NH2 radicals, thereby advancing the development of NH3‐dual fuel systems.
Long‐Term Follow‐up of Percutaneous Dilatational Tracheostomy in the Intensive Care Unit
Authors: Patel Ram , Gandhi Karan , Dzioba Agnieszka , Khan Halema , Leeper William R. , Strychowsky Julie E. , MacNeil Danielle , Mendez Adrian 
Published: February 2025

ObjectiveThe primary objective was to analyze percutaneous dilatation tracheostomy (PDT) management in the intensive care unit (ICU) by comparison with surgical tracheostomy (ST) outside of the ICU, with respect to: (i) long‐term postoperative outcomes, including rate of follow‐up, return to the emergency department, and major and minor complications; (ii) timing of decannulation, including time to decannulation, decannulation after >30 days, and decannulation at discharge. The secondary objective was to compare perioperative outcomes, including major and minor complications.MethodsA retrospective study from April 2013 to 2024 at a tertiary referral center. Eligible patients included those over 18 years old without PDT contraindications who received PDT in the ICU or ST.ResultsFinal analysis included 250 patients (125 [50%] PDT; 125 [50%] ST). The mean (SD) age of patients was 60.05 (16.41) years, and 85 (34.0%) were female. Compared with the ST group, the PDT group experienced significantly decreased long‐term follow‐up (41 [39.8%] vs. 115 [95.0%], respectively, p < 0.001), increased emergency department returns (61 [64.2%] vs. 31 [26.1%], p < 0.001), longer time to decannulation (estimated median difference: 11.00 days [95% CI: 7.00 to 15.00, p < 0.001]), increased decannulation after >30 days (23 [34.8%] vs. 13 [12.7%], p < 0.001), and similar postoperative complications (8 [8.4%] vs. 8 [6.8%], p = 0.664). The PDT group experienced significantly more perioperative complications (37 [30.1%] vs. 22 [17.6%], p = 0.021).ConclusionThe decreased long‐term follow‐up, delayed decannulation, and increased complications after PDT highlight potential pitfalls in ICU tracheostomy management, demonstrating the need for refined protocols, appropriate consultant involvement, and improved patient selection.Level of Evidence3 Laryngoscope, 2025
Renewable Phenolic Resins Based on Nitrogen‐Coordinated Cyclic Boronic Ester Bonds
Authors: Wang Lu , Chang Yuyao , Luo Yu , Zhang Yijie , Jing Xinli , Fan Wei , Wang Shujuan 
Published: February 2025

AbstractPhenolic resins (PRs) are known for their exceptional performance due to their 3D cross‐linked structure formed during curing. However, this crosslinking makes them non‐reprocessable and difficult to recycle, leading to significant environmental pollution and resource waste. In this study, the reactivity of the phenolic hydroxyl group in thermoplastic PR (abbreviated as NR) is utilized to introduce a highly stable nitrogen‐coordinated cyclic boronic ester (NCB) group into traditional carbon‐chain polymers with the aid of aliphatic isocyanates. This dynamic cross‐linked polymer, based on NCB linkages, not only deforms conveniently under appropriate stimuli but also retains excellent dimensional stability and mechanical properties in service environments. This approach gives full play to the good processability and mechanical performance of NR, enabling the closed‐loop recycling of waste phenolic resins. This method provides a promising solution for sustainable and efficient recycling, offering a novel pathway to reduce the environmental impact of phenolic resins.
Fabrication of a High Proton‐Conducting Sulfonated Fe‐Metal Organic Framework‐Polytriazole Composite Membranes: Study of Proton Exchange Membrane Properties
Authors: Kamble Riddhi , Ghanti Bholanath , Pradhan Debabrata , Banerjee Susanta 
Published: February 2025

AbstractA series of hybrid composite membranes including polymer‐metal‐organic frameworks (MOFs), are synthesized using sulfonated Fe‐MOF and sulfonated polytriazole (PTSF). After being post‐modified by 1,3‐propane sultone, the obtained Fe‐S MOF is incorporated into the polytriazole polymer matrix through the solution blending method. Additionally, a series of polytriazole with a degree of sulfonation of 60 is prepared, with the percentage of the Fe‐S MOF ranging from 3 to 9 weight percent. A comparison is made between the properties of these hybrid membranes and those of the pristine membranes. The hybrid membranes demonstrate a high degree of solubility in every solvent that is employed. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) confirm that the MOF is distributed uniformly throughout the polymer matrix. Moreover, well‐separated morphologies are confirmed by transmission electron microscopy (TEM). The prepared hybrid membranes demonstrate enhanced proton conductivities, water absorption, and swelling, all of which are accomplished without influencing the oxidative stability values.
Movement Disorders in Hereditary Cerebellar Ataxia
Authors: Damásio Joana , Costa Sara , Moura João , Santos Mariana , Lemos Carolina , Mendes Alexandre , Oliveira Jorge , Barros José , Sequeiros Jorge 
Published: February 2025

AbstractBackgroundHereditary cerebellar ataxia (HCA) represents a complex group of disorders, with a wide spectrum of neurological symptoms. Among these, non‐ataxia movement disorders (MD) have been increasingly acknowledged, with variable frequency across different forms.ObjectivesTo characterize the type and frequency of MD in patients with HCA. To identify factors associated with MD and analyze their impact on disability.MethodsWe conducted a prospective study starting in 2017, with annual visits according to a structured protocol. Patients were selected from the study database and their clinical and genetic features analyzed.ResultsThe cohort comprised 193 symptomatic patients. Machado‐Joseph disease (MJD, also SCA3 or ATX‐ATXN3) and cerebellar ataxia, neuropathy and vestibular areflexia syndrome (ATX‐RFC1) were the most common autosomal dominant (AD) or recessive forms, with a frequency of 14.0% and 15.0%, respectively. MD were present in 95 (54.4%), with dystonia being the most common (49.2%). Tremor was identified in 10.9%, Parkinsonism in 4.1% and chorea in 3.6% patients. Myoclonus and tics were rare (2.6% and 0.5%). The presence of MD was associated with AD inheritance and ATXN3. MD, regardless of type, correlated with higher SARA score at baseline, increased fall frequency, confinement to wheelchair, and earlier occurrence of falls and of permanent use of walking aid.ConclusionsMovement disorders, particularly dystonia, were common in our cohort. This highlights the possible role of the cerebellum in MD, but also extra‐cerebellar involvement in some HCA. Presence of MD significantly worsened motor disability, highlighting the need for strategies of early identification and tailored management.
Psychological Distress and Quality of Life in Families With a Germline CDKN2A Pathogenic Variant
Authors: Onnekink A. M. , Klatte D. C. F. , van Hooft J. E. , van den Berg S. H. , van der Zwaan S. M. S. , van Doorn R. , Hinnen S. C. H. , Potjer T. P. , Bleiker E. M. A. , van Leerdam M. E. 
Published: February 2025

ABSTRACTBackgroundIndividuals with a germline CDKN2A pathogenic variant (PV) have an increased lifetime risk of melanoma and pancreatic cancer. It is unknown whether the CDKN2A PV impacts quality of life (QoL). Therefore we aimed to assess QoL and psychological distress in families affected by the PV.MethodsThis cross‐sectional study included confirmed carriers and those with a 50% likelihood of carrying the PV (at‐risk carriers) under cancer surveillance who were invited to complete a one‐time questionnaire. Both confirmed and at‐risk carriers are offered skin surveillance, whereas only confirmed carriers aged 40 years or older can participate in pancreatic surveillance.ResultsIn total, 59/247 (24%) individuals under skin surveillance only (skin surveillance group) and 188/290 (65%) individuals under both skin and pancreatic cancer surveillance (pancreatic surveillance group) responded. In both surveillance groups, health‐related QoL and general distress levels were within the general population norms. However, more than 40% of all study participants reported melanoma‐related distress. Pancreatic cancer‐related distress was experienced by 45% of the pancreatic surveillance group. Determinants of cancer‐related distress were a first‐degree relative with melanoma or pancreatic cancer, increased cancer risk perception, and poor general health perception. Over 80% of the participants felt that the benefits of cancer surveillance outweigh the disadvantages.ConclusionIn conclusion, confirmed and at‐risk carriers of the CDKN2A PV under cancer surveillance experienced similar levels of QoL and general distress compared to the general population. However, cancer‐related worry was substantial in this population. These findings can help identify individuals who may benefit from psychological support.
Mixed‐Type Multiobjective Nondifferentiable Symmetric Duality Programming Problem Over Arbitrary Cones
Authors: Balram  , Jaiswal Shubham , Dubey Ramu 
Published: February 2025

ABSTRACTIn the present article, we formulate mixed‐type multiobjective nondifferentiable symmetric duality over cone and derive the duality results under ‐‐convex and ‐‐pseudoconvex. Also, we give non‐trivial examples of ‐‐convex and ‐‐pseudoconvex and show that every ‐‐convex need not be ‐‐pseudoconvex. We give non‐trivial examples of some basic definitions used in this research area. Also, some graphs are used to understand the information better. The outcomes we obtained expand upon several earlier discoveries in the field.
Asymmetry analysis of nuclear Overhauser enhancement effect at ‐1.6 ppm in ischemic stroke
Authors: Zhao Yu , Afzal Aqeela , Zu Zhongliang 
Published: February 2025

AbstractBackgroundThe nuclear Overhauser enhancement (NOE)‐mediated saturation transfer effect at ‐1.6 ppm, termed NOE(‐1.6 ppm), has demonstrated potential for detecting ischemic stroke. However, the quantification of the NOE(‐1.6 ppm) effect usually relies on a multiple‐pool Lorentzian fit method, which necessitates a time‐consuming acquisition of the entire chemical exchange saturation transfer (CEST) Z‐spectrum with high‐frequency resolution, thus hindering its clinical applications.PurposeThis study aims to assess the feasibility of employing asymmetry analysis, a rapid CEST data acquisition and analysis method, for quantifying the NOE(‐1.6 ppm) effect in an animal model of ischemic stroke.MethodsWe examined potential contaminations from guanidinium/amine CEST, NOE(‐3.5 ppm), and asymmetric magnetization transfer (MT) effects, which could reduce the specificity of the asymmetry analysis of NOE(‐1.6 ppm). First, a Lorentzian difference (LD) analysis was used to mitigate direct water saturation and MT effects, providing separate estimations of the contributions from the guanidinium/amine CEST and NOE effects. Then, the asymmetry analysis of the LD fitted spectrum was compared with the asymmetry analysis of the raw CEST Z‐spectrum to evaluate the contribution of the asymmetric MT effect at ‐1.6 ppm.ResultsResults show that the variations of the LD quantified NOE(‐1.6 ppm) in stroke lesions are much greater than that of the CEST signals at +1.6 ppm and NOE(‐3.5 ppm), suggesting that NOE(‐1.6 ppm) has a dominating contribution to the asymmetry analysis at ‐1.6 ppm compared with the guanidinium/amine CEST and NOE(‐3.5 ppm) in ischemic stroke. The NOE(‐1.6 ppm) variations in the asymmetry analysis of the raw CEST Z‐spectrum are close to those in the asymmetry analysis of the LD fitted spectrum, revealing that the NOE(‐1.6 ppm) dominates over the asymmetric MT effects.ConclusionOur study demonstrates that the asymmetry analysis can quantify the NOE(‐1.6 ppm) contrast in ischemic stroke with high specificity, thus presenting a viable alternative for rapid mapping of ischemic stroke.
Electrodiagnostic Assessment of Peri‐Procedural Iatrogenic Peripheral Nerve Injuries and Rehabilitation
Authors: Seidel Geoffrey K. , Vocelle Amber R. , Ackers Ian S. , Scott Kenneth A. , Carl Curtis A. , Bradt Barent A. G. , Dumitru Daniel , Andary Michael T. 
Published: February 2025

ABSTRACTIatrogenic nerve injuries are a significant concern for medical professionals and the patients affected. Peri‐procedural nerve injuries result in functional deficits associated with pain and disability. The exact pathophysiology and etiology of peri‐procedural nerve injuries are complex and often elude providers. The rates of injury to specific nerves are unclear and relate to both procedural and patient specific risk factors. Initial classification of the nerve injury into neurapraxia, axonotmesis, mixed nerve injury, or possible complete transection (neurotmesis) guides rehabilitation and management. Electrodiagnostic medical consultation at least four weeks post‐injury, supplemented with nerve imaging (ultrasound and magnetic resonance imaging), can allow for accurate nerve injury classification. Supplemented with nerve imaging and detailed clinical evaluation, treatment, recovery and rehabilitation can be maximized. Recognizing nerves at risk associated with medical and surgical procedures can facilitate injury avoidance and early diagnosis. If a nerve injury is incomplete, in an optimized physiologic milieu (good glucose control, smoking cessation, etc.), there is a good potential for spontaneous (total or partial) improvement over time. Surgical referral should be considered for severe nerve injuries within 6 months, especially if there is concern for neurotmesis, and/or deteriorating nerve function. This review gives guidance for approaching peri‐procedural peripheral nerve injuries, including the timing and the role of electrodiagnostic medical consultation including serial electrodiagnostic studies in management and rehabilitation.
Relationship Between the First Undisturbed Sleep Period and Diuretic and Urine Storage States of the First Void After Sleep
Authors: Akashi Yasunori , Miki Koji , Kiba Keisuke , Yamamoto Yutaka , Fujita Kazutoshi , Hirayama Akihide 
Published: February 2025

ABSTRACTObjectiveTo explore why older men awaken to urinate within 3 h after falling asleep, we examined diuretic and urine storage states associated with the first void after falling asleep.MethodsWe enrolled 102 male patients, 50 years or older, hospitalized for prostate biopsy between November 2021 and September 2023. Patients were grouped based on their first undisturbed sleep period (FUSP): FUSP < 3 h or FUSP ≥ 3 h. A 24‐h frequency‐volume chart (FVC) was recorded. Urinary sodium, creatinine, and osmolality were measured from the first urine after sleep and upon waking. Free water clearance (FWC) and sodium clearance (SC) of the first urine after sleep were recorded. The urine storage state was calculated as the ratio of urine volume at first nocturnal voiding to the maximum voided volume (VV) according to 24‐h FVC.ResultsOverall, 86 cases were analyzed. FWC was elevated in the first urine after sleep. It was significantly higher in the FUSP < 3 h group (p = 0.041). SC was elevated in the FUSP < 3 h group for both the first urine after sleep and the urine upon waking. The urine storage state tended to be lower in the FUSP < 3 h group (p = 0.057). Multivariate analysis revealed that FWC, SC, and the urine storage state independently associated with FUSP < 3 h.ConclusionDecreased urine storage function, increased water diuresis, and increased sodium diuresis in the first urine after sleep are independent factors associated with FUSP < 3 h. Management of these factors may improve nocturia.Trial RegistrationInstitutional Review Board Certification Number: 679.
Neonatal Portal Vein Thrombosis: A Retrospective Study of Management and Follow‐Up at One Institution
Authors: Jain Suhani , Maurer Lisa , Cooper James , Correa Debra , McCormick Meghan , Devine Kaitlin , Close Allison , Braverman Erica , Squires Judy , Ritchey Arthur Kim , Nolfi‐Donegan Deirdre 
Published: February 2025

ABSTRACTBackgroundManagement of neonatal portal vein thrombosis (PVT), a relatively common type of pediatric deep vein thrombosis, is not completely standardized. Questions remain about the benefit of anticoagulation (ATC) therapy and about the optimal frequency and duration of doppler ultrasound (US) surveillance for liver complications such as portal hypertension and gastrointestinal bleeding. Current guidelines suggest reserving ATC only for occlusive PVT, highlighting a need for explicit grading of PVT in radiologic reports and a consensus approach to imaging and management.MethodsTo address these issues, we implemented an institutional Neonatal PVT Management Algorithm using plan–do–study–act (PDSA) methodology. We aimed to standardize screening tests, reduce unnecessary ATC, and optimize imaging checkpoints. A five‐year retrospective review established baseline data, which we compared to outcomes five years post‐implementation of the algorithm.ResultsThe algorithm recommended ATC only for occlusive PVT and advised US imaging at Week 1, Month 1, Month 3, and Month 6 from diagnosis, with annual surveillance for unresolved or abnormal cases. Post‐implementation analysis revealed improvements in radiologic documentation of PVT grading, a reduction in the use of ATC for subocclusive PVT, and a decrease in the median duration of ATC for all patients. Follow‐up imaging adherence did not improve between the pre‐ and post‐implementation periods.ConclusionsThe algorithm successfully enhanced documentation of PVT grading and reduced unnecessary ATC but highlighted persistent challenges in follow‐up adherence, suggesting a need for further refinement in future PDSA cycles.
The Lived Experience of Childhood Cancer Survivors and Their Parents: A Multi‐National Study of Access to Survivorship Care and Information and Support Needs
Authors: McLoone Jordana K. , Wakefield Claire E. , Glasson N. , Wiener Lori , Ortiz R. , Ilbawi Andre , Schilstra Clarissa E. , Hoffman Ruth , Cayrol Julie 
Published: February 2025

ABSTRACTIntroductionLifelong follow‐up care for childhood cancer survivors (CCS) is recommended and ideally involves both medical and psychosocial care. It is important for CCS and their families to be adequately informed about what to expect after cancer treatment completion to ensure they receive appropriate care. This study aimed to describe patterns of access to survivorship care among a multi‐national sample, as well as examine unmet information and support needs, for CCS and their parents.MethodAn online survey, developed by pediatric psycho‐oncology experts and people with lived experience of pediatric cancer, was distributed by the World Health Organization. This study presents a subanalysis from these data.ResultsParticipants included 102 parents of CCS (94 females, mean age 45 years, mean time since child's diagnosis 9 years), and 43 CCS (28 females, mean age 31 years, mean time since diagnosis 21 years) from 17 countries. Thirty‐five percent of CCS (13/37) were not accessing survivorship care. Most parents (95%; 97/102) and CCS (76%; 31/41) reported a desire for discussion of emotional impacts following cancer treatment completion; however, this did not occur for 69% (70/102) of parents and 46% (19/41) of CCS. Additionally, 92% (93/102) of parents and 83% (33/41) of CCS reported an unmet need for more information about what to expect after cancer treatment. Most CCS (54%; 22/41) reported feeling “somewhat—not at all” supported by healthcare professionals in the period after cancer treatment.ConclusionDiscussions regarding emotional well‐being and ongoing needs post treatment are lacking in cancer survivorship care worldwide.