bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acupuntura na dor crônica musculoesquelética: mecanismos de ação
Authors: Ciolfi Gabriel Maraia , Bianco Otávio Augusto Fernandes Marques , Almeida Marcos dos Santos de 
Published: May 2024

Introdução: A acupuntura é uma técnica milenar chinesa que utiliza a inserção de agulhas em pontos específicos para promover a melhora sintomática de diversos problemas de saúde. Dentre eles se destaca a dor musculoesquelética, que é diretamente responsável por altos índices de absenteísmo laboral e má qualidade de vida. O tratamento desse tipo de dor é convencionalmente feito por fármacos. Contudo, o uso de métodos não-farmacológicos, em especial a acupuntura, tem se mostrado eficaz na melhora deste sintoma. Os mecanismos de ação dessa abordagem ainda não são completamente compreendidos. O que aumenta o interesse no aprofundamento do tema. ; Objetivo: Compreender os mecanismos de ação responsáveis pela modulação da nocicepção na acupuntura ; Método: Trata-se de uma revisão narrativa na qual foi feita a busca computadorizada de artigos através de bases de dados PubMed, ScienceDirect e Scielo, até março de 2024; Resultado: As teorias acerca da regulação nociceptiva englobam diferentes potenciais meios de atuação como a regulação das vias ascendente e descendente da dor, liberação de purinas, produção de endorfinas, produção de mediadores inflamatórios e ativação do sistema endocanabinóide. Conclusão: Ainda não está completamente elucidado o mecanismo pelo qual a acupuntura oferece o controle álgico. Contudo, há confluência entre as diversas teorias que buscam explicar esse fenômeno. Levando a crer que há não um, mas vários mecanismos de ação promovidos pela acupuntura.
Metallic Copper-Based Dual-Enzyme Biomimetic Nanoplatform for Mild Photothermal Enhancement of Anticancer Catalytic Activity
Authors: Chen Ziqun , Li Ying , Xiang Qi , Wu Yunfang , Ran Haitao , Cao Yang 
Published: May 2024

Background:
Chemodynamic therapy (CDT) is recognized as a promising cancer treatment. Recently, copper sulfide nanostructures have been extensively employed as Fenton-like reagents that catalyze the formation of acutely toxic hydroxyl radicals (·OH) from hydrogen peroxide (H
2
O
2
). However, CDT therapeutic potency is restricted by the tumor microenvironment (TME), such as insufficient amounts of hydrogen peroxide, excessive glutathione levels, etc. To address these disadvantages, glucose oxidase (GOx) or catalase (CAT) can be utilized to enhance CDT, while low therapeutic efficacy still inhibits their future applications. Our previous study revealed that mild photothermal effect could boost the CDT catalytic effectiveness as well as GOx enzyme activity over a range.

Results:
We engineered and constructed a hollow CuS nanoplatform loaded with GOx and CAT, coating with macrophage membranes (M@GOx-CAT@CuS NPs). The nanoplatforms allowed enhancement of the reactive oxygen species creation rate and GOx catalytic activeness of CDT through mild phototherapy directed by photoacoustic imaging. After actively targeting vascular cell adhesion molecule-1 (VCAM-1) in cancer cells mediated by macrophage membrane coating, M@GOx-CAT@CuS NPs released GOx and CAT under near-infrared irradiation. GOx catalyzed the formation of H
2
O
2
and gluconic acid with glucose, creating a better catalytic environment for CDT. Meanwhile, CAT-catalyzed H
2
O
2
decomposition to generate sufficient oxygen, appropriately alleviating the oxygen shortage in the TME. In addition, starvation effects decreased adenosine triphosphate levels and further underregulated heat shock protein expression to reduce the heat resistance of tumor cells, resulting in a better mild phototherapy outcome. Both in vitro and in vivo experiments demonstrated that the newly developed M@GOx-CAT@CuS nanoplatform has remarkable synergistic anticancer therapeutic effects.

Conclusion:
The cascade reaction-enhanced biomimetic nanoplatform opens up a new avenue for precision tumor diagnostic and therapeutic research.
PERAN PEMERINTAH DESA DALAM MENDUKUNG PENDIDIKAN ANAK-ANAK DESA TERPENCIL
Authors: Wahyudi Wahyudi , Mahdiansyah Mahdiansyah 
Published: May 2024

Penelitian ini bertujuan untuk mengetahui peran pemerintah desa dalam mendukung pendidikan Masyarakat Desa Terpencil melalui berbagai program kegiatan yang dilakukan secara terstruktur. Jenis Penelitian yang digunakan adalah deskriptif kualitatif dengan model studi kasus pada Desa Long Pada Kecamatan Sungai Tubu Kabupaten Malinau sebagai salah satu desa dengan kategori wilayah 3T (Terdepan, Terluar, Tertinggal) atau terpencil. Teknik pengumpulan data yaitu observasi, wawancara dan dokumentasi. Informan penelitian ini adalah kepala desa, aparat desa, dan masyarakat Long Pada khususnya yang masuk usia sekolah. Teknik analisis data dilakukan dengan cara pengumpulan data, reduksi data, penyajian data dan penarikan kesimpulan. Berdasarkan hasil penelitian dapat diketahui kondisi pendidikan di Desa Long Pada yang memiliki banyak masalah seperti kurangnya sarana-prasarana pendidikan dan putus sekolah. Peran Pemerintah Desa dalam menyelesaikanÂ masalah antara lain sebagai motivator dengan memberikan motivasi kepada orang tua siswa dan anak-anak agar tetap rajin sekolah agar dapat meraih cita-cita, sebagai mobilisator yaitu menggerakkan masyarakat agar sadar dan peduli pentingnya pendidikan dengan cara saling membantu, dan sebagai fasilitator yaitu memberikan layanan pendidikan kepengurusan Surat keterangan tidak mampu dan surat rekomendasi untuk kepengurusan program Paket maupun program beasiswa â€œDesa Sarjanaâ€.
Analisis Perbandingan Kuat Tekan Beton Antara Campuran Agregat Kasar Batu Pecah (Split) dan Agregat Kasar Batu Alam Sungai Noling
Authors: Adriansyah Muhammad Rafdy 
Published: May 2024

Penelitian ini bertujuan untuk membandingkan agregat kasar batu pecah (split) dan agregat kasar batu alam yang berasal dari sungai noling, Kabupaten Luwu, Sulawesi Selatan sebagai campuran beton. Penelitian ini termasuk penelitian eksperimen dengan melakukan uji kuat tekan beton di laboratorium. PPengujian kuat tekan beton dilakukan pada umur beton 3, 7, dan 28 hari menggunakan silinder dengan diameter 150 mm dan tinggi 300 mm dengan mutu beton yang direncanakan yaitu K-250. Hasil penelitian menunjukkan bahwa kuat tekan beton yang menggunakan campuran agregat kasar batu pecah lebih tinggi dibandingkan dengan campuran agregat kasar batu alam. Adapun nilai kuat tekan beton dengan menggunakan campuran agregat kasar batu pecah didapatkan pada umur 3 hari 184,381 kg/cm2, 7 hari 221,489 kg/cm2, dan 28 hari 257,437 kg/cm2, sedangkan kuat tekan beton menggunakan campuran agregat kasar batu alam sungai noling pada umur 3 hari 178,583 kg/cm2, 7 hari 197,137 kg/cm2, dan 28 hari 251,639 kg/cm2 yang mana kedua campuran agregat kasar tersebut mampu memenuhi kuat tekan rencana.
This research was conducted to compare coarse crushed stone aggregate (Split) and natural stone coarse aggregate from the noling river, Luwu Regency, South Sulawesi as a concrete mixture by conducting concrete compressive strength tests in the laboratory. Concrete compressive strength test were carried out at concrete ages of 3, 7, and 28 days using cylinders with a diameter of 150 mm and a height of 300 mm with the planned concrete quality K-250. The results of the research show that the compressive strength of concrete using a mixture of coarse crushed stone aggregate is higher than mixture of coarse natural stone aggregate. The compressive strength value of concrete using a coarse crushed stone aggregate mixture was obtained at 3 days 184,381 kg/cm2, 7 days 221,489 kg/cm2, and 28 days 257,437 kg/cm2 while the compressive strength of concrete using a coarse aggregate mixture of noling river natural stone at 3 days 178,583 kg/cm2, 7 days 197,137 kg/cm2, dan 28 days 251,639 kg/cm2 where both coarse aggregate mixtures are able to meet the planned compressive strength.
Crystallization Process Design by Proximal Policy Optimization
Authors: Tancev Georgi 
Published: May 2024

Chemical process design is the search for an optimal manufacturing
protocol to perform chemical operations. For transient processes such as
crystallization, the optimal conditions can change over time, requiring
a dynamic strategy. Model-free deep reinforcement learning is an
approach that can be used to identify the best sequence of states with
respect to a predefined reward function. In this work, proximal policy
optimization is applied in a simulated environment to identify
operational strategies that are optimal with respect to the desired
particle properties in unseeded batch cooling crystallization processes
of paracetamol in ethanol. For this purpose, the corresponding Markov
decision process is formulated, and it is shown that the method is
promising for the development of novel routes that allow the tuning of
particle size (623 μm) and provide high yields (96%) within a defined
period of time (12 h).
Antibacterial Activity of Ethanol Extracts from Leaves and Flowers of Katang-Katang Ipomoea pes-caprae (L) R.Br Against Pseudomonas aeruginosa
Authors: Wibowo Risky Hadi , Nabella Inastia , Fitri Sabrina , Rahmawati Suci , Hermansyah Oky , Masrijal Camelia Dwi Putri , Slamet Samwilson , Mashudi Mashudi , Hidayah Thoriqul 
Published: May 2024

The resistance character and infection pathogenicity of bacteria to humans is currently increasing, so there is a need for new alternative drugs. The bioactive compounds contained in katang-katang plant are one of the new sources of antibacterials obtained from nature. This study used leaves and flower samples of Katang-katang (Ipomoea pes-caprae (L)R.Br) obtained from the coastal area of Bengkulu City. The purpose of this study was to determine the phytochemical compounds of the leaves and flower extracts of Katang-katang using color reaction test method and to determine the antibacterial activity of the extracts of the leaves and flowers of Katang-katang against the testing pathogenic bacteria (Pseudomonas aeruginosa) at concentrations of 10%,25%,50%,75% using disc diffusion method. The leaves and flowers ethanolic extracts of the Katang - katang were proven contain secondary metabolites such as alkaloids, flavanoids, saponins, tannins and steroids. Antibacterial effectiveness of the ethanol extract from leaves was classified as moderate at a concentration of 50% with a measured inhibition zone of 6.30 mm and a concentration of 75% with an inhibition zone size 8.13 mm. In contrast, effectiveness of the antibacterial extracted from flower was classified as weak at a concentration of 50% with an inhibition zone 4.50mm and moderate at a concentration of 75% with a measured inhibition zone size of 6.40 mm. The experiment revealed that the leaves and flowers of the Katang-katang have antibacterial potential against P. aeruginosa which could be developed as a medicinal ingredient in the future
Application of the Discovery Learning Model to Improve Students' Science Process Skills on Virus Material
Authors: Tangahu Sela Restia , Hasan Ani M. , Ahmad Jusna , Latjompoh Masra , Retnowati Yuliana , Husain Ilyas 
Published: May 2024

Based on the results of a researcher interview with one of the biology teachers at SMAN 3 Gorontalo, science process skills have been applied before, but in their implementation they do not get maximum results so that science process skills in students do not develop. The purpose of the study was to improve the science process skills of students who used the Discovery Learning model on virus material. This type of research is descriptive quantitative with Pre-Experimental Design research methods and One group pretest and posttest designs. The subjects in this study were 31 students of grade X-4 SMA Negeri 3 Gorontalo. The indicators of science process skills observed in this study consist of aspects of observing, interpreting, applying concepts, grouping, and communicating. The results obtained the average pretest score was 45.21%, and the average posttest score was 77.75%. From the results of the study, it can be concluded that the science process skills of grade X students of SMA Negeri 3 Gorontalo can be improved through the application of the Discovery Learning model
HEALTH-RELATED QUALITY OF LIFE IN POSTMENOPAUSAL WOMEN WITH ADVANCED BREAST CANCER RECEIVING ADJUVANT HORMONE THERAPY (RIBOCICLIB AND LETROZOLE)
Authors: Rohman Syahru , Anwarudin Wawang , Azizah Nur , Mauludin Mochammad Nur Isnaeni , Sya’bany Anna Khalida 
Published: May 2024

Breast cancer is a type of cancer that affects many women in Indonesia. Adjuvant hormone therapies, such as letrozole and ribociclib, have succeeded in improving the patient's quality of life. This study aimed to assess the quality of life of postmenopausal women with advanced breast cancer who received adjuvant hormone therapy with ribociclib and letrozole. A cross-sectional study was conducted using retrospective data from postmenopausal female breast cancer patients at Dharmais Cancer Hospital between 2020 and 2023 who met the inclusion criteria. To determine the impact of sociodemographics on patient quality of life, data were examined using the quality of life score (EQ5D5L) and Spearman test. There were 29 patients, with a mean age of 54.9 years (SD = 8.65); the highest education level was high school (34.5%); The majority of occupations are housewives (69%), and the majority are stage IV (34.5%). The mean utility and VAS values of Ribociclib were 0.885 and 81.66, respectively, whereas those for letrozole were 0.725 and 78.46, respectively. Analysis of the relationship between quality of life and patient characteristics showed that the quality of life of patients with breast cancer treated with adjuvant ribociclib and letrozole therapy was influenced by the stage of breast cancer (p = 0.008). These findings indicate that patients receiving ribociclib and letrozole therapy have a good quality of life, which quality of life quality of life is influenced by the stage of malignancy.
Keywords: breast cancer, quality of life, letrozole, ribociclib, post menopause
Principle of Good Faith in Peace Agreements via Mediation
Authors: Jasmaniar Jasmaniar , Nurhaedah Nurhaedah 
Published: May 2024

Many people have selected mediation as a dispute resolution procedure to get the best agreement and solution. However, it is not uncommon for parties to fail to consistently implement an agreement reached through mediation. The purpose of this article is to examine the essence of peace agreements reached through mediation, as well as the importance of the principle of good faith as a form of protection for the parties involved in such agreements. This is normative research that takes both a statutory and conceptual approach. The exploration of data in the form of primary and secondary legal materials was carried out through a literature review and descriptive-qualitative analysis. The analytical results reveal that the mediation process, which concludes with a peace agreement, represents the end of a dispute based on the ideals of benefit and justice. On that premise, its execution must be based on the principle of good faith to provide legal protection to the parties, whether mediation takes place in or out of court. Good faith in implementing a peace agreement is interpreted as an attitude that develops within the parties in dispute to carry out their commitments as a moral obligation to obey and accomplish things that have been agreed upon voluntarily.
Modeling Molecular Hydrogen in Low-metallicity Galaxies
Authors: Polzin Ava , Kravtsov Andrey V. , Semenov Vadim A. , Gnedin Nickolay Y. 
Published: May 2024

Abstract
We use a suite of hydrodynamics simulations of the interstellar medium (ISM) within a galactic disk, which includes radiative transfer, a nonequilibrium model of molecular hydrogen, and a realistic model for star formation and feedback, to study the structure of the ISM and H2 abundance as a function of local ISM properties. We show that the star formation rate and structure of the ISM are sensitive to the metallicity of the gas with a progressively smoother density distribution with decreasing metallicity. In addition to the well-known trend of the H I–H
2
transition shifting to higher densities with decreasing metallicity, the maximum achieved molecular fraction in the ISM drops drastically at Z ≲ 0.2 Z
⊙ as the formation time of H2 becomes much longer than a typical lifetime of dense regions of the ISM. We present accurate fitting formulae for both volumetric and projected

f

H

2

measured on different scales as a function of gas metallicity, UV radiation field, and gas density. We show that when the formulae are applied to the patches in the simulated galaxy, the overall molecular gas mass is reproduced to better than a factor of ≲1.5 across the entire range of metallicities and scales. We also show that the presented fit is considerably more accurate than any of the previous

f

H

2

models and fitting formulae in the low-metallicity regime. The fit can thus be used for modeling molecular gas in low-resolution simulations and semi-analytic models of galaxy formation in the dwarf and high-redshift regimes.
Les transformations du package de contrôle en contexte austéritaire : les leçons de quatre études de cas longitudinales
Authors: Gourbier Léonard , Guenon Marcel 
Published: May 2024

La crise économique et financière de 2008 a favorisé l’émergence d’un management de l’austérité dans les organisations publiques. Celui-ci a induit des transformations profondes dans les pratiques et systèmes de contrôle de gestion. Basée sur quatre études de cas longitudinales dans des collectivités territoriales françaises, notre recherche mobilise une approche par les packages de contrôle qui met en lumière le nombre et la diversité des éléments de contrôle mobilisés pour « gérer » l’austérité. Nous montrons également qu’en contexte austéritaire, le package de contrôle des organisations oscille de façon cyclique entre une approche contraignante destinée à produire des économies rapides et une approche habilitante destinée à rechercher du consensus.
Are it -Clefts Really “Cleft” Constructions?
Authors: Lacassain Christelle 
Published: May 2024

Cet article propose une analyse des clivées en it en tant qu’illustrations d’un cas particulier d’extraposition, celui d’un syntagme nominal complexe incluant une relative restrictive. Pour ce faire, il s’intéresse à la genèse des clivées en it, à leur construction et à leur fonctionnement. Une analyse qualitative, fondée sur un corpus, permet d’identifier les propriétés et les spécificités des clivées, qui examine aussi les analyses syntaxiques et sémantiques traditionnelles et compare les clivées à d’autres constructions marquées, non canoniques, apparentées : l’extraposition et le pseudoclivage. Notre hypothèse sur la genèse des clivées permet également d’expliquer les cas d’accord ou de déconnexion entre la matrice et la subordonnée. L’étude montre ainsi que les clivées ne sont pas de simples outils syntaxiques mais que leur syntaxe est motivée sémantiquement et cognitivement. Il apparaît donc que les clivées constituent une catégorie unique et unifiée tant sur le plan syntaxique que sémantique.
Les métropoles françaises pratiquent-elles une gouvernance de Smart City ? Une évaluation par leur Système d’Information Financier Extra-Organisationnel (SIFEO)
Authors: Michel-Clupot Muriel , Rouot Serge 
Published: May 2024

L’article propose une analyse de la gouvernance des métropoles françaises à partir des contenus discursifs et des fonctionnalités de leur Système d’Information Financier Extra-Organisationnel (SIFEO). La smart city y est abordée comme objet de recherche et caractérisée par de grands champs d’action (Giffinger et al. , 2007), parmi lesquels : la gouvernance. De nature différente, elle prend le pas sur les autres, qu’elle contribue à mettre en œuvre. La recherche inscrit ces éléments de gouvernance propres à la smart city , dans le cadre d’analyse du système de gouvernance publique proposé par Mazouz et al. (2012, 2015) selon quatre niveaux, allant des institutions aux outils de gestion. Déployée sur l’ensemble des métropoles françaises, la démarche empirique est double. Dans un premier temps, il s’agit d’évaluer si leur SIFEO véhicule les thématiques constitutives d’une smart city , soit l’« intelligence discursive ». Le contenu informatif et communicationnel est étudié au moyen d’une analyse textuelle automatisée. Dans un second temps, il s’agit d’étudier le SIFEO comme un outil de gouvernance de la smart city , soit l’« intelligence fonctionnelle », avec une grille d’analyse ad hoc évaluant l’information, la communication et la participation. Les données collectées font l’objet d’une ACM révélatrice des pratiques de gouvernance. Les résultats montrent l’hétérogénéité des pratiques en la matière, corroborant ceux d’études antérieures : si les métropoles tiennent des discours sur la gouvernance, les fonctionnalités des sites et les pratiques sont en revanche très contrastées. Quelques-unes mettent bien en œuvre le triptyque de la smart gouvernance : Information – Communication – Participation et se révèlent être de véritables smart cities . À l’inverse, les autres utilisent de manière très limitée les fonctionnalités du SIFEO : une majorité d’entre elles semble correctement informer et communiquer, sans aller au bout de la démarche, et ignore la participation citoyenne. Les métropoles françaises ne sont pas toutes des smart cities ; certaines pratiquent un smart washing , utilisant l’image positive de la smart city . Plus précisément, l’utilisation du SIFEO pour mesurer l’intelligence de la ville autorise quatre gradations : Smart City , Smart Washing , Mute Smart City et Not Smart . Au-delà de ces différents constats, le SIFEO propose un nouveau cadre d’analyse et constitue un véritable outil d’évaluation de la gouvernance, contribuant à sa conceptualisation (Rodriguez-Bolivar et Meijer, 2015).
Comment les maires ont tué la Métropole du Grand Paris
Authors: Ronai Simon 
Published: May 2024

En Île-de-France, la décentralisation de 1982-1983 s’est d’abord traduite par une montée en puissance des maires, la région n’obtenant le contrôle de la politique des transports que 17 ans plus tard. Les années 2000-2020 ont vu le triomphe de la métropolisation, avec le projet de nouveau métro, le Grand Paris Express, mais pas l’apparition d’un pouvoir métropolitain fort. La Métropole du Grand Paris, créée en 2016 après de nombreuses péripéties législatives, est un acteur faible, du fait de l’opposition de l’ensemble des autres acteurs politiques : la région Île-de-France, la Ville de Paris, les sept autres départements et la quasi-totalité des maires. Chacun défendant ses intérêts et ses positions de pouvoir. Emmanuel Macron a, semble-t-il, renoncé à réformer la gouvernance du Grand Paris, tandis que se multiplient les manœuvres des uns et des autres (tentative de fusion des Yvelines et des Hauts-de-Seine, fusion de la Ville et du département de Paris, candidature d’un proche de la présidente de la région à la tête de la Métropole, etc.).