bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in biogenic amines of silver carp (Hypophthalmichthys molitrix) fillets stored at different temperatures and their relation to total volatile base nitrogen, microbiological and sensory score
Authors: Shi Ce , Cui Jianyun , Lu Han , Shen Huixing , Luo Yongkang 
Published: June 2012

AbstractBACKGROUND: Biogenic amines have received considerable attention owing to their undesirable effects in humans. There are few studies of changes in biogenic amine contents related to freshwater fish. Silver carp is an important freshwater fish species in China. This study aimed to investigate the changes in biogenic amines and their relation to total volatile base nitrogen (TVB‐N), microbiological and sensory score of silver carp fillets stored at 0, 3 and 15 °C.RESULTS: The total biogenic amine contents of all silver carp fillets (regardless of storage time and temperature) ranged from 13.05 to 318.10 mg kg−1. Putrescine and histamine were the main biogenic amines in silver carp fillets during storage. Cadaverine was only detected after 12 days at 3 °C and after 2 days at 15 °C. Spermidine and spermine contents increased during the early storage period and then slightly decreased.CONCLUSION: Low temperature could control the quality of silver carp fillets by inhibiting the contents of biogenic amines. Putrescine showed significant correlation with TVB‐N, total aerobic content, sensory score, tryptamine and phenylethylamine. Putrescine was a good quality marker of silver carp fillets in the cold chain. Copyright © 2012 Society of Chemical Industry
Chemical composition and sensory quality of bovine milk as affected by type of forage and proportion of concentrate in the feed ration
Authors: Larsen Mette K , Kidmose Ulla , Kristensen Troels , Beaumont Pierre , Mortensen Grith 
Published: June 2012

AbstractBACKGROUND: The objective of this study was to investigate how some small changes in the forage content of maize and lucerne silage and in the ration between forage and concentrate in the diet of dairy cows affect milk quality. Milk quality was assessed by quantitative descriptive sensory analysis and by analysis of tocopherols and carotenoids as well as fatty acid composition.RESULTS: Changing the ratio between maize silage and lucerne silage from 5:1 to 2:1 increased milk fat content of carotenoids (23–27%) and C18:3 n3 (15%), and reduced stale aroma and creamy flavour. Increasing the proportion of concentrates in the feed ration from 0.2 to 0.4 increased energy corrected milk yield (26%), reduced fat content (−10%), increased C18 fatty acids (8–62%) and reduced C16 (−20%) content in milk fat. In addition, this milk type was described by the sensory panel as less oily, less saturated and less yellow. The changes in milk composition were related to differences in feed composition.CONCLUSION: The study revealed the potential to produce milk with a distinct composition and sensory quality based on even small changes in the feed composition that are straightforward to implement by farmers. Copyright © 2012 Society of Chemical Industry
Use of honey bees (Apis mellifera L.) to detect the presence of Mediterranean fruit fly (Ceratitis capitata Wiedemann) larvae in Valencia oranges
Authors: Chamberlain Keith , Briens Mathilde , Jacobs Jennifer H , Clark Suzanne J , Pickett John A 
Published: June 2012

AbstractBACKGROUND: When fruit deteriorates a characteristic profile of volatile chemicals is produced that is different from that produced by healthy fruits. The identification of such chemicals allows the possibility of monitoring the fruit for early signs of deterioration with biological sensors. The use of honey bees and other insects as biological sensors is well known. This study aimed to identify the volatiles produced by oranges infested with larvae of the Mediterranean fruit fly and to test the ability of honey bees, conditioned to this volatile chemical profile, to detect such oranges.RESULTS: Seventeen compounds that were present in higher concentrations in the volatile profiles of infested oranges than in those of insect‐free fruits were mixed at the same relative concentrations as those in the collected volatiles of infested oranges. The synthetic mixture was used to train honey bees by classical Pavlovian conditioning and subsequent tests showed that they were then able to discriminate between medfly‐infested and uninfested oranges.CONCLUSION: This study demonstrates an innovative way of detecting, at an early stage, the symptoms of damage to oranges by the Mediterranean fruit fly. Copyright © 2012 Society of Chemical Industry
Risk of superficial squamous cell carcinoma developing in the head and neck region in patients with esophageal squamous cell carcinoma
Authors: Katada Chikatoshi , Muto Manabu , Nakayama Meijin , Tanabe Satoshi , Higuchi Katsuhiko , Sasaki Tohru , Azuma Mizutomo , Ishido Kenji , Katada Natsuya , Yamashita Keishi , Nemoto Masayuki , Shibata Tomotaka , Masaki Takashi , Okamoto Makito , Koizumi Wasaburo 
Published: June 2012

AbstractObjectives/Hypothesis:Multicentric squamous dysplasia in the esophagus can be visualized by Lugol chromoendoscopy as multiple Lugol‐voiding lesions (LVLs). Narrow‐band imaging combined with magnifying endoscopy (NBI‐ME) facilitates the detection of superficial squamous cell carcinoma within the head and neck region (HNSCC). We investigated risk factors for superficial HNSCC in patients with esophageal squamous cell carcinoma (ESCC).Study Design:Case‐control study.Methods:We studied 71 patients with synchronous or former ESCC. All patients underwent screening of the head and neck by NBI‐ME and Lugol chromoendoscopy of the esophageal mucosa. The history of tobacco and alcohol use was documented. Genetic polymorphisms of aldehyde dehydrogenase type 2 (ALDH2) were identified by the sequence‐specific primer polymerase chain reaction. Clinical factors related to superficial HNSCC were analyzed.Results:All patients with superficial HNSCC were drinkers. On univariate analysis, multiple LVLs (odds ratio [OR], 56.92; 95% confidence interval [CI] 6.93‐467.38; P < .001), ALDH2‐2 allele (OR, 14.48; 95% CI, 1.8‐116.56; P = .01), current smoker (OR, 4.25; 95% CI, 1.44‐12.57; P = .009), and smoking index ≥1,000 (OR, 3.45; 95% CI, 1.19‐9.99; P = .02) were associated with superficial HNSCC. On multivariate analysis, multiple LVLs (OR, 61.12; 95% CI, 5.4‐691.64; P = .001), ALDH2‐2 allele (OR, 16.19; 95% CI, 1.15‐228.06; P = .04), and current smoker (OR, 8.02; 95% CI, 1.09‐59.22; P = .04) were associated with superficial HNSCC.Conclusions:Patients with ESCC, particularly drinkers, current smokers, and those with the ALDH2‐2 allele and multiple LVLs, have an increased risk of superficial HNSCC.
Cerebrospinal fluid proteomic patterns discriminate Parkinson's disease and multiple system atrophy
Authors: Ishigami Noriko , Tokuda Takahiko , Ikegawa Masaya , Komori Mika , Kasai Takashi , Kondo Takayuki , Matsuyama Yumiko , Nirasawa Takashi , Thiele Herbert , Tashiro Kei , Nakagawa Masanori 
Published: June 2012

AbstractThe differential diagnosis of Parkinson's disease and multiple system atrophy can be challenging, especially in the early stages of the diseases. We developed a proteomic profiling strategy for parkinsonian diseases using mass spectrometry analysis for magnetic‐bead‐based enrichment of cerebrospinal fluid peptides/proteins and subsequent multivariate statistical analysis. Cerebrospinal fluid was obtained from 37 patients diagnosed with Parkinson's disease, 32 patients diagnosed with multiple system atrophy, and 26 patients diagnosed with other neurological diseases as controls. The samples were from the first cohort and the second cohort. Cerebrospinal fluid peptides/proteins were purified with C8 magnetic beads, and spectra were obtained by matrix‐assisted laser desorption ionization time‐of‐flight mass spectrometry. Principal component analysis and support vector machine methods are used to reduce dimension of the data and select features to classify diseases. Cerebrospinal fluid proteomic profiles of Parkinson's disease, multiple system atrophy, and control were differentiated from each other by principal component analysis. By building a support vector machine classifier, 3 groups were classified effectively with good cross‐validation accuracy. The model accuracy was well preserved for both cases, training by the first cohort and validated by the second cohort and vice versa. Receiver operating characteristics proved that the peak of m/z 6250 was the most important to differentiate multiple system atrophy from Parkinson's disease, especially in the early stages of the disease. A proteomic pattern classification method can increase the accuracy of clinical diagnosis of Parkinson's disease and multiple system atrophy, especially in the early stages. © 2012 Movement Disorder Society
Twenty‐five years of deep brain stimulation: Celebrations and apprehensions
Authors: Hariz Marwan 
Published: June 2012

AbstractThe year 2012 marks the 25th anniversary of the birth of modern deep brain stimulation (DBS), which was introduced by Benabid et al in 1987, initially to treat tremor with DBS of the ventral intermediate nucleus of the thalamus. The subsequent extension of DBS to the subthalamic nucleus (STN), demonstrating its efficacy on virtually all symptoms of advanced Parkinson's disease (PD), sparked an era of intense clinical and research activities, eventually transcending PD and movement disorders to encompass mood and mind. Investigations of the role of DBS in a variety of neurological, psychiatric, cognitive, and behavioral conditions is ongoing. Serendipitous discoveries and advances in functional imaging are providing “new” brain targets for an increasing number of pathologies. Toward the end of this quarter of a century of DBS, there have been some indications that the field may be at risk of gliding down a slippery slope, reminiscent of the excesses of the old‐era DBS. Although there are many reasons this year to celebrate the achievements of 25 years of modern DBS, there are also reasons to fear the opening of a new Pandora's box. © 2012 Movement Disorder Society
LBM–DEM modeling of fluid–solid interaction in porous media
Authors: Han Yanhui , Cundall Peter A. 
Published: June 2012

SUMMARYThree porous media flow problems, in which the fluid mechanical interactions are critical, are studied in a mesoscopic–microscopic coupling system. In this system, fluid flow in the pore space is explicitly modeled at mesoscopic level by the lattice Boltzmann method, the geometrical representation and the mechanical behavior of the solid skeleton are modeled at microscopic level by the particulate distinct element method (DEM), and the interfacial interaction between the fluid and the solids is resolved by an immersed boundary scheme. In the first benchmark problem, the well‐known and frequently utilized Ergun equation is validated in periodic particle and periodic pore models. In the second problem, the upward seepage problem is simulated over three stages: The settlement of the column of sphere under gravity loading is measured to illustrate the accuracy of the DEM scheme; the system is solved to hydrostatic state with pore space filled with fluid, showing that the buoyancy effect is captured correctly in the mesoscopic–microscopic coupling system; then, the flow with constant rate is supplied at the bottom of the column; the swelling of the ground surface and pore pressure development from the numerical simulation are compared with the predictions of the macroscopic consolidation theory. In the third problem, the fluid‐flow‐induced collapse of a sand arch inside a perforation cavity is tested to illustrate a more practical application of the developed system. Through comparing simulation results with analytical solutions, empirical law and physical laboratory observations, it is demonstrated that the developed lattice Boltzmann–distinct element coupling system is a powerful fundamental research tool for investigating hydromechanical physics in porous media flow. Copyright © 2012 John Wiley & Sons, Ltd.
Stable time step estimates for mesh‐free particle methods
Authors: Joldes Grand Roman , Wittek Adam , Miller Karol 
Published: June 2012

SUMMARYReal‐time computational biomechanics for medicine usually uses explicit time integration, because of its efficiency and suitability for parallel implementation. Explicit time integration is only conditionally stable and therefore requires an estimation of the maximum stable time step that can be used. In this paper we develop a method of estimating the stable time step for mesh‐free particle methods for a specific case of mass lumping: the mass associated with an integration point is distributed equally to all nodes found in the support domain of that integration point. Two estimates of the stable time step for each integration point are developed: one that is very accurate but more costly to compute and one less accurate but easier to implement. The results are also valid for the FEM and beyond computational biomechanics for medicine. Copyright © 2012 John Wiley & Sons, Ltd.
An eigenerosion approach to brittle fracture
Authors: Pandolfi A. , Ortiz M. 
Published: June 2012

SUMMARYThe present work is concerned with the verification and validation of a variant of the eigenfracture scheme of Schmidt et al. (2009) based on element erosion, which we refer to aseigenerosion. Eigenerosion is derived from the general eigenfracture scheme by restricting the eigendeformations in a binary sense: they can be either zero, in which case the local behavior is elastic, or they can be equal to the local displacement gradient, in which case the corresponding material neighborhood is failed oreroded. When combined with a finite‐element approximation, this scheme gives rise toelement erosion, i.e., the elements can be either intact, in which case their behavior is elastic, or be completly failed, or eroded, and have no load bearing capacity. We verify the eigenerosion scheme through comparisons with analytical solutions and through convergence studies for mode I fracture propagation, both in two and three dimensions and for structured and random meshes. Finally, by way of validation, we apply the eigenerosion scheme to the simulation of mixed modes I–III experiments in poly‐methyl methacrylate plates.Copyright © 2012 John Wiley & Sons, Ltd.
Plasma proteomics of differential outcome to long‐term therapy in children with idiopathic pulmonary arterial hypertension
Authors: Yeager Michael E. , Colvin Kelley L. , Everett Allen D. , Stenmark Kurt R. , Ivy D. Dunbar 
Published: June 2012

PurposeThe prognosis for children with IPAH unresponsive to therapy is poor. We investigated the plasma proteome for a molecular basis of good versus poor outcome to long‐term vasodilator therapy.Experimental designPlasma was collected at baseline or shortly after therapy initiation and following chronic vasodilator therapy, then divided into those with good outcome (n = 8), and those with a poor outcome (n = 7). To identify proteins unique to either outcome, we used differential gel electrophoresis and mass spectrometry. Results were confirmed by commercial enzyme‐linked immunosorbent assay.ResultsBefore and after therapy, SAA‐4 was 4‐fold lower in those with good outcome compared to those with poor outcome, while serum paraoxonase/arylesterase‐1 was increased 2‐fold in those with good outcome versus poor outcome. After therapy, haptoglobin and hemopexin were 1.45‐ and 1.8‐fold lower, respectively, in those with a good versus poor outcome. Among those with a good outcome, SAP was 1.3‐fold lower prior to therapy.Conclusions and clinical relevanceSAP and SAA‐4 regulate circulating mononuclear phagocytes. As such, they may contribute to the differential response to chronic vasodilator therapy in the context of inflammation in IPAH.
Wigner‐Smith delay times and the non‐Hermitian Hamiltonian for the HOCl molecule
Authors: Barr A.M. , Reichl L.E. 
Published: June 2012

AbstractWe construct the scattering matrix for a two‐dimensional model of a Cl atom scattering from an OH dimer. We show that the scattering matrix can be written in terms of a non‐Hermitian Hamiltonian whose complex energy eigenvalues can be used to compute Wigner‐Smith delay times for the Cl‐OH scattering process. We compute the delay times for a range of energies, and show that the scattering states with the longest delay times are strongly influenced by unstable periodic orbits in the classical dynamics.
Stepwise introduction of model complexity in a generalized master equation approach to time‐dependent transport
Authors: Gudmundsson V. , Jonasson O. , Arnold Th. , Tang C‐S. , Goan H.‐S. , Manolescu A. 
Published: June 2012

AbstractWe demonstrate that with a stepwise introduction of complexity to a model of an electron system embedded in a photonic cavity and a carefully controlled stepwise truncation of the ensuing many‐body space it is possible to describe the time‐dependent transport of electrons through the system with a non‐Markovian generalized quantum master equation. We show how this approach retains effects of the geometry of an anisotropic electronic system. The Coulomb interaction between the electrons and the full electromagnetic coupling between the electrons and the photons are treated in a non‐perturbative way using “exact numerical diagonalization”.
Bianchi identities for non‐geometric fluxes from quasi‐Poisson structures to Courant algebroids
Authors: Blumenhagen R. , Deser A. , Plauschinn E. , Rennecke F. 
Published: June 2012

AbstractStarting from a (non‐associative) quasi‐Poisson structure, the derivation of a Roytenberg‐type algebra is presented. From the Jacobi identities of the latter, the most general form of Bianchi identities for fluxes (H, f, Q, R) is then derived. It is also explained how this approach is related to the mathematical theory of quasi‐Lie and Courant algebroids.
Bradykinin enhances cell migration in human prostate cancer cells through B2 receptor/PKCδ/c‐Src dependent signaling pathway
Authors: Yu Hsin‐Shan , Lin Tien‐Huang , Tang Chih‐Hsin 
Published: June 2012

AbstractBACKGROUNDProstate cancer is the most commonly diagnosed malignancy in men and shows a predilection for metastasis to the bone. Bradykinin (BK) is an inflammatory mediator, and shows elevated levels in regions of severe injury and inflammatory diseases. The aim of this study was to investigate whether Bradykinin is associated with migration of prostate cancer cells.METHODSCancer cells migration activity was examined using the Transwell assay. The c‐Src and PKCδ phosphorylation was examined by using Western blot method. The qPCR was used to examine the mRNA expression of metalloproteinase. A transient transfection protocol was used to examine NF‐κB activity.RESULTSWe found that bradykinin increased the chemomigration and the expression of MMP‐9 of human prostate cancer cells. Bradykinin‐mediated chemomigration and metalloproteinase expression was attenuated by PKCδ inhibitor (rottlerin), PKCδ siRNA, c‐Src inhibitor (PP2) and c‐Src mutant. Activations of PKCδ, c‐Src and NF‐κB pathways after bradykinin treatment was demonstrated, and bradykinin‐induced expression of metalloproteinase and chemomigration activity was inhibited by the specific inhibitor and mutant of PKCδ, c‐Src, and NF‐κB cascades.CONCLUSIONSThis study showed for the first time that the bradykinin mediates migration of human prostate cancer cells. One of the mechanisms underlying bradykinin directed migration was transcriptional up‐regulation of MMP‐9 and activation of B2 receptor, PKCδ, c‐Src, and NF‐κB pathways. Prostate 73: 89–100, 2013. © 2012 Wiley Periodicals, Inc.
Bauen mit Buddha – Ein Erfahrungsbericht aus Indien
Authors: Göppert Knut , Stockhusen Knut 
Published: June 2012

AbstractFür die Austragung der Commonwealth Games 2012 in Neu Delhi, Indien, wurden im Zeitraum zwischen 2006 und 2010 mehrere neue Sportstätten von schlaich bergermann und partner geplant. Eine Grenzerfahrung der besonderen Art des Bauens im Ausland wird anhand der Entstehungsgeschichte des Dachs über das bestehende Jawaharlal Nehru Stadion erläutert. Neben dem Mut der Regierung, sich an ein technisch sehr anspruchsvolles Projekt internationalen Standards zu wagen, erforderte das Projekt enormen Einsatz und Erfindergeist der beteiligten Teams und endete glücklich mit einem besonderen Bauwerk in einem wahrlich einzigartigen Land – Incredible India.Building with Buddha – Experience report from India. Between 2006 and 2010 several sport venues designated for the Commonwealth Games 2010 have been designed by us. Based on the experience during the construction period of the Jawaharlal Nehru Stadium the following article tells the story of a special borderline experience of working abroad. Besides the courage of the authorities to decide for a complex project of international standard, the work required intensive and devotional commitment and inventive talent by all involved parties and ended luckily with a beautiful venue within a truly unique and incredible India.
Olympiastadion Kiew
Authors: Göppert Knut , Balz Markus , Haspel Lorenz , Moschner Thomas 
Published: June 2012

AbstractDas Stadion Kiew blickt auf eine lange und wechselvolle Geschichte zurück, die bereits 1914 begann. Damals noch am Rande der Stadt erbaut, liegt es inzwischen im Stadtzentrum Kiews. Das Stadion wurde im Laufe der Zeit mehrmals umgebaut, um es für immer neue Großereignisse zu rüsten. Die maximale Kapazität des Stadions, mit zwei vollständigen Rängen und über 100.000 Plätzen, wurde 1968 erreicht, jedoch im Zuge späterer Umbaumaßnahmen wieder reduziert, um den steigenden Sicherheitsbedürfnissen gerecht zu werden. Noch heute trägt das Stadion den Namen “Olimpijskyj“, da 1980 einige Wettkämpfe der Olympischen Sommerspiele in Kiew durchgeführt wurden. Vor dem Umbau für die Fußball‐EM 2012 waren noch viele, teilweise sehr schlecht erhaltene Relikte wie olympische Reliefs, Mosaiken oder Malereien erhalten, welche von der großen Historie des Stadions zeugten. Im Fokus des neuen architektonischen Konzeptes stand der Entwurf einer unaufdringlichen leichten Struktur, die auf raumgreifende Elemente verzichtet.Olympic Stadium Kiev. The Stadium Kiev boasts a long and varied history that began in 1914. Built on the former fringes of the city, it is now in the center of Kiev. Over the years the stadium was rebuilt several times, in order to prepare for more and bigger events. The maximum capacity of the stadium, with two complete tiers and more than 100,000 seats, was reached in 1968, but then in subsequent conversion work reduced for more security. The stadium still bears the name “Olimpijskyj” since in 1980 several competitions of the Olympic Summer Games took place in Kiev. Before the conversion for the Euro 2012 the stadium still had a lot of sometimes very badly preserved relics, such as Olympic‐reliefs, mosaics and paintings, received which testified it´s great history. The focus of the new architectural concept was to design a lightweight unobtrusive structure, which dispensed from space‐consuming elements.
Policing Epistemic Deviance: Albert von Schrenck-Notzing and Albert Moll1
Authors: Sommer Andreas 
Published: June 2012

AbstractShortly after the death of Albert von Schrenck-Notzing (1862–1929), the doyen of early twentieth century German para psychology, his former colleague in hypnotism and sexology Albert Moll (1862–1939) published a treatise on the psychology and pathology of parapsychologists, with Schrenck-Notzing serving as a prototype of a scientist suffering from an ‘occult complex’. Moll’s analysis concluded that parapsychologists vouching for the reality of supernormal phenomena, such as telepathy, clairvoyance, telekinesis and materialisations, suffered from a morbid will to believe, which paralysed their critical faculties and made them cover obvious mediumistic fraud. Using Moll’s treatment of Schrenck-Notzing as an historical case study of boundary disputes in science and medicine, this essay traces the career of Schrenck-Notzing as a researcher in hypnotism, sexology and parapsychology; discusses the relationship between Moll and Schrenck-Notzing; and problematises the pathologisation and defamation strategies of deviant epistemologies by authors such as Moll.