bluuebunny/crossref_metadata_2025_split huggingface dataset:
International trends in the implementation of assessment for learning revisited: Implications for policy and practice in a post-COVID world
Authors: Volante Louis , DeLuca Christopher , Barnes Nicole , Birenbaum Menucha , Kimber Megan , Koch Martha , Looney Anne , Poskitt Jenny , Smith Kari , Wyatt-Smith Claire 
Published: May 2024

This paper discusses the evolution of assessment for learning (AfL) across the globe with particular attention given to Western educational jurisdictions. Scholars from Australia, Canada, Ireland, Israel, New Zealand, Norway, and the United States discuss prominent assessment reforms within their respective countries over the last decade. Particular attention is given to the impact of the pandemic as well as technological developments for classroom assessment policies and practices. Ongoing tensions that exist between AfL and summative forms of assessment within national policy initiatives are also revisited in relation to the seminal version of this article published 10 years ago.
Mechanical thrombectomy with Embolus Retriever with Interlinked Cages device for medium vessel occlusions: First pass results and safety profile
Authors: Bajrami Arsida , Senadim Songul , Bas Demet Funda , Erdem Eren , Geyik Serdar 
Published: May 2024

Background Reperfusion of medium vessel occlusions is correlated with good outcomes. However, optimal techniques and medical devices are still unclear. In this study, we sought to evaluate the safety and efficacy of mechanical thrombectomy with Embolus Retriever with Interlinked Cages (ERIC™) retrieval device in patients with acute ischemic stroke due to distal medium vessel occlusions. Methods A retrospective review of the prospectively collected mechanical thrombectomy database revealed 50 patients who had fulfilled the inclusion criteria. The data collected includes clinical patient characteristics, procedural measures, timestamps at each stage, and patient outcomes. Intravenous thrombolytics application, pre- and post-intervention imaging findings, device-related adverse events and any type of intracranial hemorrhage were recorded. Results There were 25 men (50%) and 25 women (50%) with a median of 67 years (interquartile range (IQR) 41–84). Median presenting NIHSS was 14 (IQR, 3–23). First pass rates were: eTICI3 in 16 cases (32%), eTICI-2c in eight cases (16%), eTICI-2B67 in nine cases (10%), eTICI2B50 in three cases (6%) and mTICI 0–2A in 18 cases (36%). Final recanalization rate of mTICI 2b-3 was 90% and 2c-3 was 70%. Conclusion In conclusion, the ERIC thrombectomy device offers a high rate of first-pass success along with a favorable safety profile. Larger series and multi-center studies are needed for further investigation.
Prior abdominal surgery is not associated with 30-day mortality or morbidities after endovascular repair of complex abdominal aortic aneurysm
Authors: Li Renxi , Sidawy Anton , Nguyen Bao-Ngoc 
Published: May 2024

Background Prior abdominal surgery (PAS) has the potential to affect outcomes of abdominal aortic aneurysm (AAA) repair. Recently, endovascular aneurysm repair (EVAR) has been expanded among patients with complex AAA, which involves visceral branches in the upper abdominal aortic. However, outcomes of EVAR for complex AAA in patients with PAS have not been examined. This study aimed to investigate the impact of PAS on 30-day outcomes in EVAR for complex AAA. Methods Patients who underwent EVAR for complex AAA were identified in ACS-NSQIP targeted database from 2012 to 2022. Complex AAA was defined as juxtarenal, suprarenal, or pararenal proximal extent, Type IV thoracoabdominal aneurysm, or aneurysms treated with Zenith Fenestrated endograft. Patients with age less than 18 years, ruptured AAA with or without hypotension, acute intraoperative conversion to open, and emergency presentation were excluded. Multivariable logistic regression was used to compare 30-day postoperative outcomes of patients with and without PAS. Demographics, baseline characteristics, aneurysm diameter, indication for surgery, proximal and distant aneurysm extent, anesthesia, and concomitant procedures were adjusted. Results There were 515 (28.34%) and 1302 (71.66%) patients with and without PAS, respectively, who underwent EVAR for complex AAA. Patients with and without PAS had comparable 30-day mortality (3.11% vs 3.00%, aOR = 0.766, 95 CI = 0.407–1.442, p = .41). Organ system complications including cardiac complications, stroke, pulmonary complications, and renal complications were comparable between patients with and without PAS. All other 30-day outcomes were similar between groups. However, patients with PAS had higher 30-day readmission rate (11.65% vs 7.14%, aOR = 1.634, 95 CI = 1.145–2.331, p = .01). Conclusion While PAS has high prevalence among patients undergoing EVAR for complex AAA, it does not impact 30-day mortality and morbidities. Thus, EVAR for complex AAA can be considered safe for patients with PAS in terms of short-term outcomes, despite the long-term prognosis in these patients being needed in further studies.
Effect of heparin for the prevention of venous thromboembolism in patients with spontaneous intracranial cerebral hemorrhage: a meta-analysis
Authors: Zhou Yifu , Wang Gang , Xue Chunxiao , He Guojun , Zhang Yan , He Feilong , He Chenjun , Liang Xiaosong 
Published: May 2024

Background: Venous thromboembolism (VTE) has a serious impact on the prognosis of patients with spontaneous intracranial hemorrhage (sICH). However, the use of prophylactic heparin remains controversial. Objectives: This study investigated the safety and timing of prophylactic heparin for VTE in patients with sICH. Design: This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines. Methods: Two authors systematically searched Web of Science, Cochrane Library, Embase, and PubMed to find all published research before June 2023. The incidence of deep venous thrombosis (DVT) and mortality were set as primary endpoints. Results: This meta-analysis included seven randomized controlled trials (RCTs) and five observational studies involving a total of 4419 sICH patients in the heparin ( n = 2808) and control ( n = 1183) groups. Among these patients, 205 received early heparin administration, while 223 received late heparin administration. The results suggested that, compared to the control group, patients in the heparin group had a lower incidence of VTE [odds ratio (OR), 0.47; 95% CI, 0.31–0.71; p < 0.001], DVT (OR, 0.53; 95% CI, 0.33–0.85; p = 0.009), pulmonary embolism (OR, 0.31 95% CI, 0.15–0.65; p = 0.002), and mortality (OR, 0.70; 95% CI, 0.54–0.90; p = 0.006), but there were no statistical differences in hematoma enlargement, extracranial hematoma, and major disability ( p > 0.05). There was no statistically significant difference in DVT, mortality, hematoma enlargement, and extracranial hemorrhage between the early heparin group (<24–48 h) and the late heparin group ( p > 0.05). Conclusion: In patients with sICH, prophylactic use of heparin may be beneficial because it reduces the incidence of VTE and mortality without increasing the risk of additional bleeding. In addition, early prophylactic use of heparin appears to be safe. However, large-scale RCTs are lacking to support this evidence.
Mapping evidence on barriers to and facilitators of diagnosing noncommunicable diseases among people living with human immunodeficiency virus in low- and middle-income countries in Africa: A scoping review
Authors: Badacho Abebe Sorsa , Woltamo Deginesh Dawit , Demissie Dereje Bayissa , Mahomed Ozayr Haroon 
Published: May 2024

Objectives: To map the evidence on the barriers to and facilitators of diagnosing noncommunicable diseases among people living with HIV in low- and middle-income countries in Africa. Introduction: Noncommunicable diseases are increasing among people living with HIV. Thus, strengthened and sustained diagnosis of noncommunicable diseases through integrated noncommunicable diseases and HIV care is needed to improve patient outcomes. However, there is paucity of evidence on the barriers and facilitators diagnosing noncommunicable diseases among people living with HIV in low- and middle-income countries. Methods: The Arksey and O’Malley methodological framework was used. A comprehensive systematic search of academic databases (MEDLINE, Academic Search Complete, APA PsycInfo, CAB, and Health Source/Nursing) was performed via EBSCO search and PubMed. The articles were reviewed independently by three reviewers. The results were structured using Capability-Opportunity-Motivation-Behavior model and Theoretical Domains Framework. Results: A total of 152 articles were retrieved for full-text review. Forty-one articles met the inclusion criteria. The identified barriers were relevant to all the Capability-Opportunity-Motivation-Behavior constructs and 14 Theoretical Domains Framework domains. A lack of knowledge and awareness of noncommunicable diseases, fear of stigma, financial problems and out-of-pocket payments were the most cited patient-level barriers. Healthcare providers (knowledge and awareness gaps, skill and competence deficiencies, unwillingness, burnout, low motivation, and apathy) were frequently cited. Lack of equipment, noncommunicable disease medications and supply chain challenges, lack of integrated noncommunicable disease and HIV care, and shortage of trained healthcare providers were identified as health-system-level barriers. Conclusion: This scoping review is the first to identify barriers and facilitators using a theoretical framework. The most cited barriers include a lack of integrated HIV and noncommunicable disease care, equipment and logistics chain challenges for noncommunicable diseases, patients’ and healthcare providers’ lack of knowledge and awareness of noncommunicable diseases, and healthcare provider’s skill and competency deficiencies. Addressing these issues is crucial for improving patient outcomes and reducing the burden on healthcare providers and health systems.
Postpartum Ogilvie syndrome, cause of acute intestinal obstruction
Authors: Elbahaoui Nezha , Lahnaoui Oumayma , Benammi Sara , Ouanani Mohamd , Errougani Abdelkader 
Published: May 2024

Lesson Ogilvie's syndrome presents as a rare complication in the postpartum period. Prompt diagnosis is crucial to prevent colonic perforation, occurring in 25 to 40% of cases, leading to significant mortality.
How do provider communication strategies predict online patient satisfaction? A content analysis of online patient-provider communication transcripts
Authors: Rui Jian Raymond , Guo Jieqiong , Yang Keqing 
Published: May 2024

Objective As a result of the growing access to the Internet, online medical platforms have gained increased popularity in China. However, which strategies doctors should use to improve their online communication with patients remains understudied. Drawing upon the performance-evaluation-outcome (PEO) model, the present study seeks to develop a typology of patient-centered communication (PCC) strategies online and identify those strategies that can increase patient satisfaction. Methods We employed the data crawling technique to access text-based patient–provider transcripts through a large medical consultation platform in China and coded 9140 conversational turns of doctors. Results Our analysis revealed 15 PCC strategies that Chinese doctors often used online. In addition, several strategies were found to enhance patient satisfaction including information provision, making diagnosis, information appraisal, emotion expression, emotion recognition and support, in-depth discussion of medical treatments, providing coping strategies, and enabling self-management. Conclusion Chinese patients may have developed multiple needs, which they expect to fulfill through their interactions with doctors. Technological affordances of online medical platforms may pressure doctors to adapt their communication strategies to patients’ needs. Our findings develop the PEO model from the perspective of patient-provider communication strategies and add a perspective centering on patients’ needs to the scholarship on patient satisfaction. In addition, these results provide practical implications on how to improve patient-provider communication online.
Microbiological and Immunological Assessment of Peri-implant Sites in Healthy and Diabetic Individuals After Prosthetic Rehabilitation: A Prospective Case Control Study
Authors: Dinesh Gera , Ramesh KSV , Penmetsa Gautami S , Swetha P , NVS Sruthima G  , Kumar P Mohan 
Published: May 2024

Aim: Microbial colonization contributes to periodontitis and peri-implantitis with an increase in proinflammatory cytokines like IL 17. This has a vital role in the destructive process of tissue and bone around the implant. Type 2 diabetes mellitus has the potential to increase these microbial colonies thus becoming a risk factor. To compare and correlate the association of peri-implant sulcular microflora and salivary IL-17 between healthy and controlled diabetic individuals. Materials and Methods: A total of 30 participants who have undergone dental implant placement with screw-retained prosthesis were included in the study. Participants were divided into two groups, healthy ( n = 15) and diabetic ( n = 15). The subgingival plaque was collected from peri-implant sites into TE buffer vials and the salivary sample was collected into Eppendorf tubes at the 7th, 14th, and 30th day. Microbiological counts of P. gingivalis, T. denticola, T .forsythia, and F. nucleatum were evaluated by polymerase chain reaction, and salivary interleukin (IL)-17 levels were obtained by enzyme-linked immunosorbent assay. Results: The bacterial count was increased in both healthy and diabetic individuals but more prevalent in diabetes. The salivary IL-17 levels were increased in diabetic individuals which was statistically significant. Conclusion: Increased microbiota in both healthy and diabetic individuals along with increased IL-17 levels can lead to peri-implantitis which provides an insight into microbiological and immunological aspects in individuals with dental implants further acting as a predictor for peri-implantitis.
A 10-Step Process to Align Problem-Based Learning With Accreditation Expectations for Self-Directed and Lifelong Learning
Authors: Al-Eyd Ghaith , Seki Tsugio , Griffin Daniel P 
Published: May 2024

OBJECTIVE Self-directed and lifelong learning (SDLL) skills are essential skillsets in both undergraduate and graduate medical education (UME and GME). Hence, medical schools’ accreditation bodies emphasize the requirements to acquire these skills in their accreditation standards. For example, in the United States, the Liaison Committee on Medical Education (LCME) clearly defines the components of the SDLL process in Element 6.3 of Accreditation Standard Six. Among the active learning pedagogies, problem-based learning (PBL) provides ample learning opportunities where SDLL skills are effectively applied. The aim of this article is to streamline the process of developing, delivering, and evaluating PBL sessions in line with the SDLL accreditation requirements through a 10-step design and implementation process. METHODS Our 10-step process, detailed in the article, starts with developing learning objectives that inform the content of the PBL case and the required embedded learning triggers. The process carefully addresses the components of the SDLL process and other aspects of the accreditation needs within the framework of PBL. The approach to implementation, feedback, assessment, and evaluation is explicitly described to meet the regulatory expectations. DISCUSSION In addition to the essential role in UME and GME, SDLL skills are vital requisites for continuing medical education of all physicians. Instilling this skillset early in medical students helps to cultivate their ability to apply these skills in their future professional roles. Using accreditation standards as a foundation for creating learning experiences, for example, PBL, requires careful content development and sequencing. Such a process needs explicit standardized steps that should not only be feasible, but also transferable for usage by different medical schools. CONCLUSION Our streamlined 10-step process of designing and delivering an SDLL-oriented PBL experience can easily be adopted by other medical schools to address the SDLL skills acquisition as well as meeting the accreditation requirements.
Atomic-scale deformation mechanisms at high-pressure in inderborite, CaMg[B3O3(OH)5]2(H2O)4⋅2H2O
Authors: Comboni Davide , Battiston Tommaso , Lotti Paolo , Hanfland Michael , Gatta G. Diego 
Published: May 2024

AbstractThe high-pressure behaviour of inderborite [ideally CaMg[B3O3(OH)5]2(H2O)4⋅2H2O, space group C2/c with a≈ 12.14, b≈ 7.43, c≈ 19.23 Å and β ≈ 90.3° at room conditions] has been studied by two in situ single-crystal synchrotron X-ray diffraction experiments up to ~10 GPa, using He as pressure-transmitting fluid. Between 8.11(5) and 8.80(5) GPa, inderborite undergoes a first-order phase transition to its high-pressure polymorph, inderborite-II (with a≈ 11.37, b≈ 6.96, c≈ 17.67 Å, β ≈ 96.8° and ΔV ≈ 7.0%, space group unknown). The isothermal bulk modulus (KV0 = β−1P0,T0, where βP0,T0 is the volume compressibility coefficient) of inderborite was found to be KV0 = 41(1) GPa. The destructive nature of the phase transition prevented any structure resolution of inderborite-II or even the continuation of the experiments at pressures higher than 10.10(5) GPa. In the pressure range 0–8.11(5) GPa, the compressional anisotropy of inderborite, indicated by the ratio between the principal components of the Eulerian finite unit-strain ellipsoid, is ɛ1:ɛ2:ɛ3 = 1.4:1.05:1. The deformation mechanisms at the atomic scale in inderborite are here described. Our findings support the hypothesis of a quasi-linear correlation between the total H2O content and P-stability range in hydrated borates, as the pressure at which inderborite undergoes the phase transition falls in line with most of the hydrate borates studied at high-pressure so far.
Effect of antibody-mediated connective tissue growth factor neutralization on lung edema in ventilator-induced lung injury in rats
Authors: van den Brom Charissa E. , Bozic Caitlin , Polet Chantal A. , Bongers Annabel , Tuip-de Boer Anita M. , Ibelings Roselique , Roelofs Joris J. T. H. , Juffermans Nicole P. 
Published: May 2024

Abstract
Background
Acute respiratory distress syndrome (ARDS) is characterized by alveolar edema that can progress to septal fibrosis. Mechanical ventilation can augment lung injury, termed ventilator-induced lung injury (VILI). Connective tissue growth factor (CTGF), a mediator of fibrosis, is increased in ARDS patients. Blocking CTGF inhibits fibrosis and possibly vascular leakage. This study investigated whether neutralizing CTGF reduces pulmonary edema in VILI.

Methods
Following LPS administration, rats were mechanically ventilated for 6 h with low (6 mL/kg; low VT) or moderate (10 mL/kg; mod VT) tidal volume and treated with a neutralizing CTGF antibody (FG-3154) or placebo lgG (vehicle). Control rats without LPS were ventilated for 6 h with low VT. Lung wet-to-dry weight ratio, FITC-labeled dextran permeability, histopathology, and soluble RAGE were determined.

Results
VILI was characterized by reduced PaO2/FiO2 ratio (low VT: 540 [381–661] vs. control: 693 [620–754], p < 0.05), increased wet-to-dry weight ratio (low VT: 4.8 [4.6–4.9] vs. control: 4.5 [4.4–4.6], p < 0.05), pneumonia (low VT: 30 [0–58] vs. control: 0 [0–0]%, p < 0.05) and interstitial inflammation (low VT: 2 [1–3] vs. control: 1 [0–1], p < 0.05). FG-3154 did not affect wet-to-dry weight ratio (mod VT + FG-3154: 4.8 [4.7–5.0] vs. mod VT + vehicle: 4.8 [4.8–5.0], p > 0.99), extravasated dextrans (mod VT + FG-3154: 0.06 [0.04–0.09] vs. mod VT + vehicle: 0.04 [0.03–0.09] µg/mg tissue, p > 0.99), sRAGE (mod VT + FG-3154: 1865 [1628–2252] vs. mod VT + vehicle: 1885 [1695–2159] pg/mL, p > 0.99) or histopathology.

Conclusions
‘Double hit’ VILI was characterized by inflammation, impaired oxygenation, pulmonary edema and histopathological lung injury. Blocking CTGF does not improve oxygenation nor reduce pulmonary edema in rats with VILI.

Graphical Abstract
Phylogenetic analysis and antigenic epitope prediction for E6 and E7 of Alpha-papillomavirus 9 in Taizhou, China
Authors: Yuan Haobo , Yan Ziyi , Gan Jun , Di Xinghong , Qiu Yi , Xu Huihui 
Published: May 2024

Abstract
Background
Alpha-papillomavirus 9 (α-9) is a member of the human papillomavirus (HPV) α genus, causing 75% invasive cervical cancers worldwide. The purpose of this study was to provide data for effective treatment of HPV-induced cervical lesions in Taizhou by analysing the genetic variation and antigenic epitopes of α-9 HPV E6 and E7.

Methods
Cervical exfoliated cells were collected for HPV genotyping. Positive samples of the α-9 HPV single type were selected for E6 and E7 gene sequencing. The obtained nucleotide sequences were translated into amino acid sequences (protein primary structure) using MEGA X, and positive selection sites of the amino acid sequences were evaluated using PAML. The secondary and tertiary structures of the E6 and E7 proteins were predicted using PSIPred, SWISS-MODEL, and PyMol. Potential T/B-cell epitopes were predicted by Industrial Engineering Database (IEDB).

Results
From 2012 to 2023, α-9 HPV accounted for 75.0% (7815/10423) of high-risk HPV-positive samples in Taizhou, both alone and in combination with other types. Among these, single-type-positive samples of α-9 HPV were selected, and the entire E6 and E7 genes were sequenced, including 298 HPV16, 149 HPV31, 185 HPV33, 123 HPV35, 325 HPV52, and 199 HPV58 samples. Compared with reference sequences, 34, 12, 10, 2, 17, and 17 nonsynonymous nucleotide mutations were detected in HPV16, 31, 33, 35, 52, and 58, respectively. Among all nonsynonymous nucleotide mutations, 19 positive selection sites were selected, which may have evolutionary significance in rendering α-9 HPV adaptive to its environment. Immunoinformatics predicted 57 potential linear and 59 conformational B-cell epitopes, many of which are also predicted as CTL epitopes.

Conclusion
The present study provides almost comprehensive data on the genetic variations, phylogenetics, positive selection sites, and antigenic epitopes of α-9 HPV E6 and E7 in Taizhou, China, which will be helpful for local HPV therapeutic vaccine development.