bluuebunny/crossref_metadata_2025_split huggingface dataset:
Supporting patient self-management: A cross-sectional and prospective cohort study investigating Patient Activation Measure (PAM) and Clinician Support for PAM scores as part of a multi-centre haemodialysis breakthrough series collaborative
Authors: Keriakos Maria , Lee Sonia , Stannard Catherine , Ariss Steven , Dunn Louese , Wilkie Martin , Fotheringham James 
Published: May 2024

Background
Patient self-management, measured by the Patient Activation Measure (PAM), is associated with reduced healthcare utilisation and better health-related quality of life. Self-management in haemodialysis (HD) is challenging and may require support from clinicians with positive attitudes towards self-management, measured by the Clinician Support for PAM (CSPAM).

Objectives
To assess whether kidney staff CSPAM scores are: 1) associated with their centre’s patient PAM scores and 2) modifiable through staff coaching.

Methods
Baseline PAM and CSPAM and six-month CSPAM were collected from HD patients and kidney staff respectively in seven UK kidney centres as part of a six-month breakthrough series collaborative (BTSC), which trained kidney staff in supporting patient independence with HD tasks. Firstly, multivariable linear regression analyses adjusted for patient characteristics were used to test the baseline association between centre-level staff CSPAM scores and patient PAM scores. Secondly, paired univariate and unpaired multivariable linear regression analyses were conducted to compare staff CSPAM scores at baseline and six months.

Results
236 PAM questionnaires (mean score = 55.5) and 89 CSPAM questionnaires (median score = 72.6) were analysed at baseline. There was no significant association between centre-level mean CSPAM scores and PAM scores in univariate analyses (P = 0.321). After adjusting for patient-level characteristics, increasing centre-level mean CSPAM score by 1 point resulted in a non-significant 0.3-point increase in PAM score (0.328 (95% CI: -0.157 to 0.812; P = 0.184). Paired (n = 37) and unpaired (n = 174) staff analyses showed a non-significant change in CSPAM scores following the BTSC intervention (mean change in CSPAM score in unpaired analysis = 1.339 (95% CI: -1.945 to 4.623; P = 0.422).

Conclusions
Lack of a significant: 1) association between CSPAM and PAM scores and 2) change in CSPAM scores suggest that modifying staff beliefs alone is less likely to influence patient self-management, requiring co-production between patients and staff.
The excessive celebrity worship behavior questionnaire: Chinese scale development and validation
Authors: He Yiqing , Liu Qinxue 
Published: May 2024

Objective
To develop a scale to assess the excessive behavior of superfans in celebrity worship and to test its reliability and validity in China.

Methods
The scale was developed based on the netnography and interviews of celebrity fans and the existing problematic Internet usage scales. Sample 1 (n = 465) was used for exploratory factor analysis, and Sample 2 (n = 804) was used for confirmatory factor analysis, reliability test, criterion validity, and discriminative validity test.

Results
There were 36 items in the final scale, including nine factors: impaired social functioning, replacement of real to virtual social relationships, sleep and eating problems, withdrawal, mood alteration, salience, excessive buying, increased craving, and escape from real life. The factor loadings ranged from 0.565 to 0.803. Confirmatory factor analysis showed that the scale was well structured. The reliability of the scale and each factor were satisfactory. The scale showed good discriminant validity in reflecting celebrity worship behavior. In terms of scores, mood alteration was the highest, excessive buying was the lowest, and there were certain gender and age differences.

Conclusion
This study initially identified the main characteristics of excessive celebrity worship behavior among young fans on social media. The developed Chinese scale has good reliability and validity and can be used as a measurement tool.
Acute and long-term outcomes of SARS-CoV-2 infection in school-aged children in England: Study protocol for the joint analysis of the COVID-19 schools infection survey (SIS) and the COVID-19 mapping and mitigation in schools (CoMMinS) study
Authors: Looker Katharine J. , McClenaghan Elliot , Judd Alison , Pierotti Livia , Downing Harriet , Phelan Jody , Warren-Gash Charlotte , Ngozi Kalu , Dawe Fiona , Relton Caroline , Christensen Hannah , Hay Alastair D. , Mangtani Punam , Nguipdop-Djomo Patrick , Denholm Rachel 
Published: May 2024

Background
The symptom profiles of acute SARS-CoV-2 infection and long-COVID in children and young people (CYP), risk factors, and associated healthcare needs, are poorly defined. The Schools Infection Survey 1 (SIS-1) was a nationwide study of SARS-CoV-2 infection in primary and secondary schools in England during the 2020/21 school year. The Covid-19 Mapping and Mitigation in Schools (CoMMinS) study was conducted in schools in the Bristol area over a similar period. Both studies conducted testing to identify current and previous SARS-CoV-2 infection, and recorded symptoms and school attendance. These research data have been linked to routine electronic health record (EHR) data.

Aims
To better understand the short- and long-term consequences of SARS-CoV-2 infection, and their risk factors, in CYP.

Methods
Retrospective cohort and nested case-control analyses will be conducted for SIS-1 and CoMMinS data linked to EHR data for the association between (1) acute symptomatic SARS-CoV-2 infection and risk factors; (2) SARS-CoV-2 infection and long-term effects on health: (a) persistent symptoms; (b) any new diagnosis; (c) a new prescription in primary care; (d) health service attendance; (e) a high rate of school absence.

Results
Our study will improve understanding of long-COVID in CYP by characterising the trajectory of long-COVID in CYP in terms of things like symptoms and diagnoses of conditions. The research will inform which groups of CYP are more likely to get acute- and long-term outcomes of SARS-CoV-2 infection, and patterns of related healthcare-seeking behaviour, relevant for healthcare service planning. Digested information will be produced for affected families, doctors, schools, and the public, as appropriate.

Conclusion
Linked SIS-1 and CoMMinS data represent a unique and rich resource for understanding the impact of SARS-CoV-2 infection on children’s health, benefiting from enhanced SARS-CoV-2 testing and ability to assess a wide range of outcomes.
Study of the photoperiodic dynamics of the peripheral dopamine content in comparison with the thyroid profile in various groups of men from the European North
Authors: Tipisova E. V. , Zyabisheva V. N. , Alikina V. A. , Elfimova A. E. , Molodovskaya I. N. 
Published: May 2024

BACKGROUND: Knowledge of the physiological mechanisms of adaptation arising in response to changes in photoperiods is especially important for residents of the European North. In the literature, there is practically no information about photoperiodic dynamics of serum dopamine level, despite its significant role in the regulation of the body’s activity. The mutual modulating effect of the dopaminergic and thyroid systems is known.AIM: To show the ratio of dopamine levels and the content of hormones, protines and autoantibodies of the thyroid system, taking into account photoperiod of the year, in practically healthy populations of the European North.MATERIALS AND METHODS: Healthy male population (20 men) of Arkhangelsk was examined in various photoperiods of the year (80 samples): an increase in the length of daylight hours (March), its maximum duration (June), a decrease (September), and a minimum duration (December). The inhabitants of the settlements and the nomadic aboriginal population (100 men) were examined during 2 photoperiods of the year — March and December. The serum levels of iodothyronines, TSH, TG, antibodies to TPO, antibodies to TG and plasma level of dopamine were determined using ELISA methods.RESULTS: Residents of Arkhangelsk in June compared to December have higher levels of dopamine (0.502 and 0.365 nmol/l, p=0.01), T3 (1.09 and 0.94 nmol/l, p=0.003), T4 (113.45 and 99.03 nmol/l, p=0.0002). In September, compared with June, a decrease in dopamine (0.235 nmol/l, p=0.0003), T3 (0.92 nmol/l, p=0.004) was recorded with an increase in T4/T3 ratio from 106.54 to 117.89 units (p=0.006). The nomadic aboriginal population in March compared with December showed a tendency to a higher content of dopamine (0.00 and 0.394 nmol/l, p=0.07) with the decrease in fT4 (15.20 and 13.90, p=0.015), fT4/fT3 ratio from 3.13 to 2.28 units (p=0.006). In December, 67% of nomadic population had undetectable dopamine values (0 nmol/l) and 22% — excess dopamine values, in March 27% — excess values.CONCLUSION: Unidirectional changes in dopamine and thyroid activity in men of the European North were shown with their decrease during periods of decrease and minimum daylight hours and an increase during periods of increase and maximum daylight hours.
Thyrotropin-secreting pituitary adenomas: clinical features and results of treatment in 45 patients
Authors: Trukhina D. A. , Przhiyalkovskaya E. G. , Belaya Zh. E. , Grigoriev A. Yu. , Azizyan V. N. , Mamedova E. O. , Rozhinskaya L. Ya. , Lapshina A. M. , Pigarova E. A. , Dzeranova L. K. , Platonova N. M. , Troshina E. A. , Melnichenko G. A. 
Published: May 2024

BACKGROUND: Thyrotropin-secreting pituitary adenomas (TSH-PA) are a rare cause of thyrotoxicosis and account for 0.5-2% of all pituitary adenomas. Taking into account the rarity of the disease, it is extremely important to analyze each case of TSH-PA. AIM: To analyze the clinical characteristics and treatment outcomes of patients with TSH-PA, as well as to determine preoperative and early postoperative factors that predict long-term remission.MATERIALS AND METHODS: In a single-center retrospective study we analyzed clinical signs, laboratory and instrumental studies, as well as the treatment outcomes of patients with TSH-PA from 2010 to 2023. Preoperative factors, as well as TSH level measured on day 3 postoperatively, were evaluated for their ability to predict long-term remission when comparing groups of patients with and without remission. RESULTS: The study included 45 patients with TSH-PA (14 men, 31 women), with a median age of 45 years [30; 57]. The most common clinical manifestations of TSH-PA were: cardiac arrhythmia in 37 (82.2%) patients, thyroid pathology in 27 (60%), neurological disorders in 24 (53.35%). Most PAs were macroadenomas (n=35, 77.8%). Preoperatively, 28 (77.8%) patients received somatostatin analogs, and 20 (71.4%) patients were euthyroid at the time of surgery. Surgical treatment was performed in 36 (80%) patients, postoperative remission was achieved in 31 cases (86.1%). Administration of somatostatin analogues to patients with no remission/relapse after surgery lead to the remission in 100% of cases (4/4). A 1 mm increase in PA size raised the odds of recurrence/no remission by 1.15-fold,and PA invasion during surgery — by 5.129 fold. A TSH level on day 3 postoperatively above 0.391 mIU/L (AUC, 0.952; 95% CI 0.873–1.000; standard error 0.04; p<0.001) identifies patients with relapse/absence of remission after surgical treatment (sensitivity = 100%, specificity = 88.9%).CONCLUSION: The TSH-PA in the structure of PAs is extremely rare, and as a result, most of them are misdiagnosed and detected already at the stage of macroadenoma. The most effective method of treatment is transnasal transsphenoidal adenomectomy. Somatostatin analogues can be used as second-line therapy if surgical treatment is ineffective. We have proposed a possible model for postoperative TSH levels (>0.391 mU/l) to predict recurrence of TSH-PA, which requires validation on an expanded number of cases.
Toxic manifestations of alpelisib in endocrinology. Description of the clinical case
Authors: Kudaeva L. M. , Kozhedub E. E. , Kupryshina V. O. , Aliyev T. Z. , Troshina E. A. 
Published: May 2024

Breast cancer (BC) is a serious disease and is considered an important health problem worldwide. The prevalence of the disease in women according to Rosstat was 64,951 cases in the Russian Federation in 2020 (21.7% among all types of cancer). Hormone-dependent estrogen receptor-positive (HR+), human epidermal growth factor receptor type 2 negative (HER2-) metastatic breast cancer (mBC) accounts for 70% of all cases. About 40% of patients with ER+/HER2- mBC have mutations in the PIK3CA gene, leading to hyperactivation of the alpha isoform (p110α) of phosphatidylinositol 3-kinase (PI3K). Hormonal therapy with or without cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor is considered the standard treatment for patients with ER+/HER2- mBC. However, acquired resistance to this therapy remains a problem. Innovative methods for the treatment of breast cancer are the use of targeted therapeutic agents aimed at direct inhibition of the PI3K pathway in combination with hormone therapy. Alpelisib is a PI3Kα-specific inhibitor. Hyperglycemia is the most common side effect of alpelisib treatment. Currently, there is a consensus on the prevention and correction of hyperglycemia in patients receiving therapy with alpelisib, which recommends that before starting therapy, in order to diagnose carbohydrate metabolism disorders and assess the risk of developing hyperglycemia, determine in all patients: the level of glycated hemoglobin (HbA1c), glucose fasting plasma (FPG), body mass index (BMI). And also to evaluate such risk factors as the presence of a family history of type 2 diabetes mellitus (DM 2), the presence of gestational diabetes in the patient’s history, or the fact of the birth of children weighing more than 4 kilograms.Recently, new combinations of drugs have been actively used to treat disorders of carbohydrate metabolism, such as pioglitazone + metformin. This paper discusses the mechanism of action of PI3K inhibitors, new therapeutic combinations and their undesirable effects, and presents therapeutic experience.
REVISÃO SISTEMÁTICA SOBRE A PRODUÇÃO CIENTÍFICA COM ÊNFASE NA RELAÇÃO ENTRE VULNERABILIDADE, AMBIENTE E SAÚDE
Authors: Rodrigues Willane da Silva , Ambrósio Halana Tereza Marques de Jesus , Aquino Júnior José 
Published: May 2024

Objetivo: Analisar os dados acerca da produção científica nacional e internacional sobre temáticas relacionadas a saúde e ambiente com enfoque em situações de vulnerabilidade no território brasileiro. Método: Trata-se de uma revisão ancorada nos principais itens recomendados pela declaração PRISMA. Buscou-se por artigos entre os anos de 2016 a 2021 no Portal de Periódicos CAPES. Para a seleção dos artigos, buscou-se pelas palavras chaves “vulnerabilidade, saúde e ambiente” nas línguas portuguesa e inglesa. Foram selecionados 156 artigos após aplicação dos critérios de inclusão e exclusão, e, posteriormente analisados e agrupados em classes de categorias (A e B). Resultados: Na classe A, a temática Exposição/ avaliação de riscos se sobressaiu com uma frequência de 49 artigos. Na classe B, se sobressaiu a temática Vulnerabilidade Social com uma frequência de 75 artigos. Mais da metade das publicações (65%) foram provenientes de periódicos nacionais, sendo a maioria vinculados a instituições oriundas da Região Sudeste (15,6%). Conclusão: A disparidade científica entre regiões pode mascarar problemas que afetam as áreas mais vulneráveis socioeconomicamente, como as regiões Nordeste e Norte do país, dificultando assim a gestão e planejamento de políticas públicas voltadas a promoção da saúde ambiental, bem como melhoria da qualidade de vida destas populações.
MOBILIDADE INTERESTADUAL PARA TRATAMENTO DE CÂNCER DE PELE NA REGIÃO CENTRO-OESTE DO BRASIL: UM ESTUDO ECOLÓGICO DE SÉRIE TEMPORAL
Authors: Ito Arianne Tiemi Jyoboji Moraes , Santos Bruna Nathália , Mota Adeir Archanjo da , Bernardes Sara Santos 
Published: May 2024

Este estudo tem como objetivo caracterizar os fatores clínicos, de assistência à saúde e demográficos de residentes da região centro-oeste do Brasil diagnosticados com câncer de pele, para compreender os deslocamentos interestaduais realizados para receber o primeiro tratamento da doença no Sistema Único de Saúde (SUS). Foi realizado um estudo ecológico analítico de série temporal, que analisou características do atendimento à população no período de 2008-2018, usando a base de dados dos Registros Hospitalares de Câncer e do Sistema de Informações de Mortalidade. As medidas de associação entre as variáveis foram realizadas utilizando os testes de Fisher e de Qui-quadrado. 42,2% dos casos registrados foram encaminhados para outra Unidade Federativa (UF) para realizar o primeiro tratamento, 77,9% dos casos registrados em Goiás iniciaram tratamento em outra UF, e quase todos os casos do DF realizaram o primeiro tratamento na mesma UF. Goiás (77,3%) e Mato Grosso (42,5%) foram os estados que mais encaminharam usuários para outra UF, e São Paulo a que mais recebeu usuários. A mortalidade por câncer de pele aumentou 44% nesse período, principalmente em Goiás e Mato de Grosso do Sul. Os resultados destacam variáveis associadas a deficiência na assistência oncológica na região, que requerem estratégias para maior acessibilidade aos tratamentos.
A agroecologia e a multirreferencialidade do currículo
Authors: Barthes Angela , Basconi Tatiane Cristina Fernandes , Lengthorn Elena Elizabeth , Chalando Véronique , Gibert Anne-Françoise , Souza José Gilberto de 
Published: May 2024

O ensino da agroecologia questiona suas referências e seu posicionamento entre ciência, prática e política. O conhecimento estruturante deve estar estabelecido nas epistemologias do conhecimento politicamente situado, ou seja, um conhecimento que se processa com intencionalidade dos sujeitos sociais na transformação concreta do real . Neste sentido, é importante exigir a multirreferencialidade, a problematização e o reconhecimento das relações de poder e de injustiça. Propomos refletir sobre os objetivos da educação intencionalmente débil ou solida e explicá-los através de um modelo de educação política aplicado à agroecologia. A discussão centra-se nas possibilidades curriculares de uma educação transformadora que inclua, entre outras coisas, a complexidade das questões em jogo, a interdependência dos sistemas, a interdisciplinaridade e a justiça social.
Empirical uncertainty evaluation for the pose of a kinematic LiDAR-based multi-sensor system
Authors: Ernst Dominik , Vogel Sören , Neumann Ingo , Alkhatib Hamza 
Published: May 2024

AbstractKinematic multi-sensor systems (MSS) describe their movements through six-degree-of-freedom trajectories, which are often evaluated primarily for accuracy. However, understanding their self-reported uncertainty is crucial, especially when operating in diverse environments like urban, industrial, or natural settings. This is important, so the following algorithms can provide correct and safe decisions, i.e. for autonomous driving. In the context of localization, light detection and ranging sensors (LiDARs) are widely applied for tasks such as generating, updating, and integrating information from maps supporting other sensors to estimate trajectories. However, popular low-cost LiDARs deviate from other geodetic sensors in their uncertainty modeling. This paper therefore demonstrates the uncertainty evaluation of a LiDAR-based MSS localizing itself using an inertial measurement unit (IMU) and matching LiDAR observations to a known map. The necessary steps for accomplishing the sensor data fusion in a novel Error State Kalman filter (ESKF) will be presented considering the influences of the sensor uncertainties and their combination. The results provide new insights into the impact of random and systematic deviations resulting from parameters and their uncertainties established in prior calibrations. The evaluation is done using the Mahalanobis distance to consider the deviations of the trajectory from the ground truth weighted by the self-reported uncertainty, and to evaluate the consistency in hypothesis testing. The evaluation is performed using a real data set obtained from an MSS consisting of a tactical grade IMU and a Velodyne Puck in combination with reference data by a Laser Tracker in a laboratory environment. The data set consists of measurements for calibrations and multiple kinematic experiments. In the first step, the data set is simulated based on the Laser Tracker measurements to provide a baseline for the results under assumed perfect corrections. In comparison, the results using a more realistic simulated data set and the real IMU and LiDAR measurements provide deviations about a factor of five higher leading to an inconsistent estimation. The results offer insights into the open challenges related to the assumptions for integrating low-cost LiDARs in MSSs.
Ethanedithiol-modified silica nanoparticles for selective removal of Hg2+ ions from aqueous wastewater
Authors: Mohan Anandhu , Ashwini Munusamy , Santhamoorthy Madhappan , Thirupathi Kokila , Suresh Ranganathan , Guganathan Loganathan , Arumugam Natarajan , Almansour Abdulrahman I. , Lin Mei-Ching , Kim Seong-Cheol , Kumarasamy Keerthika , Vy Phan Thi Tuong 
Published: May 2024

Abstract
A mesoporous silica nanoparticle was synthesized by incorporating (3-glycidoxypropyl trimethoxysilane (GPTS)) via sol-gel co-condensation method using Pluronic P123 as structure directing agent and further reacted with ethanedithiol (ED) by post-surface modification process. To produce ethanedithiol-modified silica nanoparticles, approximately 20 wt% of GPTS was incorporated into the mesoporous silica pore walls by reacting tetraethyl orthosilicate and GPTS mixture (80:20 wt/wt%). Next, the ethanedithiol groups were introduced onto the silica surface by reacting with the epoxy part of GPTS and thiol groups of ED to produce the ED-modified-mesoporous silica adsorbent (MS-ED NPs) material. The synthesized MS-ED NPs show a high surface area, pore size, and mesopore volume of approximately 556 m2/g, 2.7 nm, and 0.052 cm3/g, respectively. The MS-ED NPs showed selective removal of mercury ions (Hg2+) ions from the aqueous solution in the presence of other competitive metal ions with an adsorption amount of ∼168 mg/g with a removal capacity of approximately >90 % from the initial metal ion solutions (100 mg/L). The produced MS-ED NPs can be reusable up to 5 times by treating the metal-adsorbed MS-ED NPs in an acidic (0.1 M HCl) aqueous solution. Hence, the MS-ED NPs could be utilized to selectively remove Hg2+ ions from aqueous wastewater.
CT diagnosis of uterine leiomyosarcoma: a case report
Authors: Wang Yubo , Wu Jialei , Fu Yang , Li Jiageng , Wang Caiqiong , Liu Yingchun , Peng Zefei , Yang Bin 
Published: May 2024

Background:
A uterine leiomyosarcoma is a relatively rare malignant tumor of the uterus with a high degree of malignancy that is prone to distant metastasis and recurrence in the early stages, and therefore has a poor prognosis. Plain and enhanced CT scans are important for the early diagnosis of uterine leiomyosarcoma.

Case report:
We report the case of a 47-year-old woman with a uterine leiomyosarcoma. A preoperative plain CT scan showed significant uterine enlargement, whereas an enhanced CT scan showed an uneven and significantly enhanced mass. A large mass was observed in the lower and middle parts of the abdomen intraoperatively. The large mass in the abdominal and pelvic cavities was a uterine mass with bilateral adnexal lesions, approximately 20 cm × 20 cm × 15 cm in size. Bilateral retroperitoneal masses were palpated. A total hysterectomy, left salpingectomy, right adnexectomy, and resection of the retroperitoneal mass were performed. The pathologic diagnosis was uterine leiomyosarcoma with bleeding and necrosis.

Conclusions:
Diagnosis of uterine leiomyosarcoma lacks clinical specificity. Imaging is helpful for early diagnosis, treatment, disease course assessment, and efficacy evaluation. Ultimately, a pathologic examination and biopsy are required to confirm the diagnosis.