bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the Diagnostic Performance and Clinical Utility of Nasal Methicillin-Resistant Staphylococcus aureus PCR Testing in Pediatric Orbital Cellulitis
Authors: Hamilton Shannon , Taylor Michael , Schneider Jack G , Howe Zachary , Sharma Meghna , Boyd LaKeisha , Manaloor John J , Chehab Hiba , Espinel Alexandra , Hamdy Rana F , Wood James B 
Published: June 2024

Abstract
Data are limited on the clinical impact of nasal methicillin-resistant Staphylococcus aureus (MRSA) polymerase chain reaction testing for orbital cellulitis. This 2-center, retrospective study demonstrated a negative predictive value of 98.0% and an overall lower use of anti-MRSA antibiotics, without a concomitant increase in hospital readmission.
(115) DISORDERS OF THYROID FUNCTION AND ERECTILE DYSFUNCTION
Authors: Broul Marek , Jozífková Eva , Kučerová Dr Petra 
Published: June 2024

Abstract

Objectives
We evaluate the relationship between erectile dysfunction and disorders of thyroid function. We confirmed that both dysfunctions are related and require treatment.

Methods
This is a retrospective evaluation of a cohort of patients treated for ED. We selected only men who were found to have any thyroid dysfunction (either hypofunction or hyperfunction) at the beginning of treatment. In total, we identified 51 men in this study. We excluded men who had any other comorbidities. Of the remaining 27 men, 9 had clinical hyperthyroidism and 18 had clinical hypothyroidism. Of the 9 men with hyperthyroidism, five had Graves-Basedow disease and four had toxic nodular goiter. After the patients were examined by an endocrinologist and treatment was initiated, we continued to monitor fT4, TSH and testosterone levels. We assessed the status of erectile function according to the IIEF-5 questionnaire.

Results
We found some form of erectile dysfunction in all men with thyroid dysfunction. All men had IIEF-5 scores less than or equal to 19 before treatment. Two men had an IIEF-5 score of 4, i.e. they suffered from complete erectile dysfunction. The mean IIEF-5 score did not differ between hyper and hypothyroid men (11.56 versus 12.61). We observed an increase in IIEF-5 scores after treatment for thyroid dysfunction, both in men with hypo and hyper thyroid function. Even in 11 men, the IIEF-5 score rose to 21 or more. One year after starting treatment for thyroid dysfunction, we showed no difference between men with hypo and hyper thyroid function.

Conclusions
Erectile dysfunction is very common in men with thyroid dysfunction. Treatment of this primary cause may affect normal erectile function. We recommend screening for thyroid dysfunction in all men with ED. Treatment of ED with iPDE5 agents need not be delayed and can be initiated prior to the initiation of treatment for thyroid dysfunction.

Conflicts of Interest
None.
(396) LOW INTENSITY - EXTRACORPOREAL SHOCK WAVE THERAPY (LI-ESWT) IN THE TREATMENT OF ERECTILE DYSFUNCTION: INITIAL EXPERIENCE AND FOLLOW UP
Authors: Saitta Dr Giuseppe , Di Paola Dr Giuseppe , Mantovani Dr Franco A , Meazza Dr Attilio L , Seveso Dr Mauro 
Published: June 2024

Abstract

Objectives
Low intensity - Extracorporeal Shock Wave Therapy (Li-ESWT) can be considered a novel promising method for treatment men with erectile dysfunction (ED), in particular after failure of medical therapy. The purpose of this study was to investigate feasibility, safety and effectiveness of this kind of therapy through a follow-up period of 12 and 18 months.

Methods
We included 102 patients with ED of vascular origin who failed to respond to oral PDE5-I. The International Index of Erectile Function (IIEF) and Erection Hardness Score (EHS) questionnaires were used to evaluate erectile function. All patients had an EHS of 2 or less with PDE5-I. The patients underwent to one session of Li-ESWT per week for 6 weeks. During each session 3000 shocks (energy density 0.09 mJ/mm2 and frequency 120/min) were erogated. Patients were considered responders to ESWT whenever they showed improvement in erection parameters (IIEF and EHS) 3 or greater: erection hard enough to permit vaginal penetration. Side effects were recorded.

Results
All patients completed follow up. Mean age was 63.9 years (31-82), mean duration of ED was 22 months (5-40). IIEF score was 11 at baseline, 21 at 12 months follow up, 18 at 18 months; EHS improved in 72 patients at 12 months (70.6%). Younger men (&lt;45 years), short ED duration (&lt;12 months) and moderate ED severity, responded better to the treatment (p&lt;0.05). However, during follow up, a gradual decrease in efficacy was observed. Efficient parameters were mantained by 66 patients (64.7%) at 12 months and by 54 patients (52.9%) at 18 months. No adverse events were reported during or after treatment.

Conclusions
Li-ESWT offers a valid therapeutic option in patients with erectile dysfunction, particularly within 12 months. The beneficial effect seems to diminish in the final assessment. Multicentre controlled studies and longer follow up are needed.

Conflicts of Interest
No.
(382) MALE ERECTILE DYSFUNCTION IN PATIENTS RECOVERED FROM COVID-19: IS IT A PERSISTENT PROBLEM?
Authors: Menafra Dr Davide , de Angelis Cristina , Castoro Dr Michele , Garifalos Dr Francesco , Verde Dr Nunzia , Gentile Prof Ivan , Bocchino Prof Marialuisa , Ruggiero Prof Lucia , Jannini Prof Emmanuele AF , Colao Prof Annamaria , Pivonello Prof Rosario 
Published: June 2024

Abstract

Objectives
The current study aimed at investigating the occurrence of erectile dysfunction (ED) as a potential component of the Long Covid-19 Syndrome, and at addressing the relationship between ED and Covid-19 acute phase severity, and psychological and organic comorbidities.

Methods
Thirty-three men (median age 55 years) were recruited 145±48.6 days after a SARS-CoV-2-negative nasopharyngeal swab. Erectile function was assessed by International Index of Erectile Function 6(IIEF-6) questionnaire, and by basal(bPDU) and dynamic(dPDU) penile duplex ultrasonography, particularly including peak systolic velocity(PSV) and end diastolic velocity (EDV). Neuro-psychological symptoms were assessed by BDI, STAY, FSS, AES. Moreover, PDU parameters of 13 Covid-19 patients with IIEF-6-confirmed ED were compared to 13 control patients matched for age, IIEF-6 score and comorbidities.

Results
In the Covid-19 group 18/28(64.3%) patients were affected by ED at IIEF-6, 13(46.4%) had mild, 3(10.7%) moderate and 2(7.1%) severe ED. 11/32(34.4%) patients were affected by arteriogenic ED at bPDU and 10/21(47.6%) at dPDU, with 6(28.6%) mild-moderate and 4(19.0%) severe arteriogenic ED. IIEF-6 score was significantly lower in patients experiencing vs not experiencing myalgia during Covid-19 acute phase(22 vs 26; p=0.041). Mean dPSV was significantly lower (24.55±5.25 cm/s vs 32.13±5.40 cm/s; p=0.025) and prevalence of arteriogenic ED significantly higher [4/4(100%) vs 6/17(35.3%); p=0.035] in patients treated vs not treated for diabetes. EDV was negatively correlated with pO2(r=-0.762; p=0.028) and positively correlated with Chung score at chest CT(r=0.554; p=0.049).

Conclusions
The results of the current study demonstrated for the first time a high prevalence of ED, higher than that reported in the general population, in patients recovered from Covid-19, as assessed by IIEF-6 questionnaire and PDU. The current study also highlighted a potential contribution of tissue hypoxia in the Covid-19 acute phase to the veno-occlusive deficit of corpora cavernosa.

Conflicts of Interest
Nothing to declare.
(1015) COUPLE CONFLICT AND LABOR EXPERIENCE: THE SERIAL MEDIATING ROLE OF PSYCHOLOGICAL DISTRESS AND PRENATAL ATTACHMENT
Authors: Ghinassi Simon , Ponti Lucia , Tani Franca , Smorti Martina 
Published: June 2024

Abstract

Objectives
The role played by the quality of the couple relationship on the outcomes of birth is well known. In particular, couple conflict is linked to a more challenging childbirth, such as more complicated labor experience. Although this link is evident, less is known about possible mediators of this relationship. Therefore, this study aims to build upon previous evidence by examining the serial mediating role of maternal psychological distress and prenatal attachment on the relationships between couple conflict and labor experience.

Methods
A longitudinal design was carried out on 161 pregnant women (Mage = 31.63±4.88). At weeks 31–32 of gestation, women filled out the Romance Qualities Scale, the Beck Depression Inventory, the State Anxiety Inventory, and the Prenatal Attachment Inventory. The day of childbirth, hospital healthcare staff registered the clinical data of labor (duration of labor, administration of oxytocin and epidural analgesia in hours). To verify the hypothesized model a Structural Equation Modeling was performed. The indirect effects were tested using the bootstrapping method with 5,000 bootstrap samples.

Results
The assessed structural model produced adequate fit to the data [χ2 = 20.084, df = 13, p = 0.093; RMSEA = 0.058 (90% C.I. = 0.010–0.106), CFI = 0.985, SRMR = 0.029] and the variables in the model accounted for 47% of the variance in labor experience. Couple conflict affects the experience of labor only indirectly, both through the serial mediating role of psychological distress and prenatal attachment (β = 0.04; 95% CI: [0.002-0.046]) and through the mediation of psychological distress (β = 0.10; 95% CI: [0.011-0.098]).

Conclusions
Overall, the results showed that couple conflict during pregnancy has negative outcomes, affecting indirectly the labor experience. These findings have important clinical implications for potential couple interventions during pregnancy that may favor a less complicated labor experience.

Conflicts of Interest
No conflicts of interest to declare.
(264) FEMALE SEXUAL HEALTH AFTER OBSTETRIC ANAL SPHINCTER INJURY (OASI): A SCOPING REVIEW
Authors: Gibrael Hevy S , Linhardt Signe , Toldam Nana E , Jangö Hanna , Thomsen Louise , Dreier Sabine , Giraldi Prof Annamaria , Graugaard Prof Christian 
Published: June 2024

Abstract

Objectives
Sexual health is an essential aspect of women’s well-being throughout life. However, pregnancy and childbirth cause biological, psychological, and social changes that can impact negatively on sexual health. Studies have thus indicated that sexual function often declines during pregnancy and may not fully recover to pre-pregnancy levels in the postpartum period. Unfortunately, healthcare providers often overlook addressing sexual aspects during this crucial time. With approximately 90% of women sustaining perineal tears during vaginal birth and 1-6 % being affected by obstetric anal sphincter injury (OASI), the current scoping review aims to assess the existing evidence on the associations between OASI and postpartum sexual health. Specifically, the review investigates the domains of sexual functioning, activity, and satisfaction.

Methods
PubMed, Embase, Scopus, Cinahl and Cochrane were systematically searched for relevant peer-reviewed papers as well as grey literature. Studies were selected in a three-stage process involving title and abstract assessment, complete article evaluation, and inclusion meeting predefined criteria. Only original quantitative studies providing statistical evidence on the impact of OASI on postpartum sexual health were included. The initial search yielded 749 articles, with 26 selected for inclusion.

Results
OASI impacted women's sexual health postpartum. In particular, women with OASI had delayed resumption of sexual intercourse compared to those with no or tears of lower degrees although the majority had resumed their coital activity twelve months postpartum. According to most studies, OASI increased the risk of dyspareunia, which oten persisted several years after birth. Also, these women were more likely to develop other long-term consequences, such as fecal incontinence, which can lead to, or exacerbate, sexual problems.

Conclusions
Women with OASI have increased risk of sexual dysfunction and low coital activity. This underscores the importance of initiating conversations with women regarding their sexual health after delivery with OASI and offer referral to physiotherapy, couples therapy, or sexological expertise when necessary.

Conflicts of Interest
Declaration of conflicts of interest for all authors:
H. S. Gibrael: None.
S. Linhardt: None.
(253) ASSESSMENT OF PSYCHOSOCIAL ADAPTATION AND SEXUAL HEALTH OF WAR PARTICIPANTS
Authors: Azatyan Ruzanna , Sahakyan Satenik , Hakobyan Prof Aram , Grigoryan Arsen 
Published: June 2024

Abstract

Objectives
This study examines the assessment of socio-psychological adaptation and sexual health status of combatants and development of effective methods of rehabilitation.

Methods
The Course of Sexology of Yerevan State Medical University and Armenian Association of Sexologists (Sexual Health Protection NGO) has developed a questionnaire using various authoritative questionnaires: Clinical-Administered PTSD scale (CAPS), Mississippi Scale for Combat-Related Posttraumatic Stress Disorder (M-PTSD). The questionnaire consists of 17 questions, conducted on an anonymous voluntary basis.

Results
The study involved 384 adult men aged 18 to 58 years (mean age 26.57 ± 7.17 years). The association with aggressive irritability in the pre-war period was statistically significant as a post-war frequency (p&lt;0,05).
Statistically reliable data were obtained for people with irritability and aggression in the pre-war period, the effect of whether pre-war and post-war situations influenced sexual satisfaction was more pronounced (p&lt;0,05). The frequency of sexual intercourse before the war was not related to having sexual problems (p&gt;0,05), but post-war sexual problems were more common among those with poor family relationships (p&lt;0,05). Fair or good family relationships before the war were associated with less frequent post-war physical reactions (p &lt;0.05).

Conclusions
As a result of statistical analysis, we understand that there is direct connection between sexual satisfaction and sexual drive with the PTSD and the consequences of participation in war. Therefore, in the rehabilitation phase of war participants, referring to the recovery of sexual health, the psychosocial adaptation takes place more quickly and completely.

Conflicts of Interest
We have no conflicts of interest to disclose.
(289) IMPROVING UNDERGRADUATE MEDICAL STUDENTS’ KNOWLEDGE ABOUT THE HISTOLOGY OF THE CLITORIS AND PENIS IN RELATIONSHIP TO SEXUAL PLEASURE
Authors: Kielholz Mirjam , Badre Maeva , Brockmann Dr Celine , Soulie Dr Priscilla , Abdulcadir Dr Jasmine 
Published: June 2024

Abstract

Objectives
Sexual health is a part of global health and well-being. Comprehensive sexual health training is lacking in undergraduate medical education. Genital anatomy and physiology teaching has traditionally focused on reproductive function. Sexual physiology and the sexual response cycle are some of the basic learning objectives necessary for improving the gap in sexual health competencies in healthcare professionals.
The objective was to update the histology teaching of undergraduate medical students at the University of Geneva by including histologic sections of the glans of the clitoris and the penis, thus allowing to address sexual pleasure.

Methods
Standard H&E histology and immunohistochemistry (S100 staining to identify nervous tissue) sections of the glans of the clitoris and penis from the Geneva University Hospital Pathology Service were digitalized and made available, with their description, in the histology teaching on the reproductive system, through a digital microscopy platform.

Results
On the added sections of clitoral glans, students identified the following structures: the distal portion of the clitoral body with numerous Pacinian corpuscles in the surrounding tissue, the dorsal nerves of the clitoris, and numerous genital sensory corpuscles. On the sections of the penile glans, medical students observed the distal part of the urethra surrounded by the corpus spongiosum, nerves of the glans of the penis, and numerous genital sensory corpuscles. The students were invited to compare the two organs, finding similarities and differences as well as correlating the histological structures to their sexual response function.

Conclusions
Histology teaching for undergraduate students of the University of Geneva was successfully updated with existing histologic sections of clitoral and penile glans. This is cost-effective and adaptable to various teaching methods of different medical schools, providing medical students with foundational knowledge for an inclusive understanding of the genital sexual response.

Conflicts of Interest
The authors report no conflicts of interest. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
(197) EXPLORING THE CONNOTATION OF SEXUAL WELL-BEING
Authors: Yu Dr Pei L 
Published: June 2024

Abstract

Objectives
To explore the definition and content of sexual well-being.

Methods
The research participants are people over the age of 20 who have had sexual intercourse with their partners. One-on-one open-ended questions and text conversations are used as the main method of data collection. The study was conducted from September to December 2021. There were 37 interviewees, including 20 women (54.1%) and 17 men (45.9%); the age distribution was 20 (54.1%) between 21 and 39 years old, and 17 (45.9%) over 40 years old.

Results
The majority of participants viewed sexual well-being as alignment with their partner in sexual life, the satisfaction of sexual needs, experiencing positive emotions, and having a diverse, comfortable, and stress-free sexual life.
The content of sexual well-being mainly encompasses 13 indicators, and the content of the first 8 indicators is as follows:
1. Accommodating and satisfying sexual needs (11.6%)
2. Feeling satisfaction or positive emotions (11.1%)
3. Alignment in sexual life with the partner, with the frequency of sexual encounters not being the focus (9.5%)
4. Comfortable and stress-free sexual life (9.5%)
5. Emotional and relational compatibility with the sexual partner (6.8%)
6. Mutual understanding, empathy, and respect in sexual life (6.8%)
7. Able to have diverse and unrestrained sex (6.3%)
8. Effective communication regarding sexual life (6.3%)

Conclusions
Research results have found that a compatible sexual life with your partner is very important for sexual well-being. The frequency of sexual intercourse does not necessarily and cannot represent an individual's sexual well-being. Sexual dysfunction often affects sexual life, but only a few people mention it as an indicator of sexual happiness.

Conflicts of Interest
No.
The extreme coronal line emitter AT 2022fpx: varying optical polarization properties and late-time X-ray flare
Authors: Koljonen Karri I I , Liodakis Ioannis , Lindfors Elina , Nilsson Kari , Reynolds Thomas M , Charalampopoulos Panos , Kouroumpatzakis Konstantinos , McCall Callum , Jermak Helen E , Steele Iain A , Carbajo-Hijarrubia Juan 
Published: June 2024

ABSTRACT
Supermassive black holes disrupt passing stars, producing outbursts called tidal disruption events (TDEs). TDEs have recently gained attention due to their unique dynamics and emission processes, which are still not fully understood. Especially, the so-called optical TDEs are of interest as they often exhibit delayed or obscured X-ray emission from the accretion disc, making the origin of the prompt emission unclear. In this paper, we present multiband optical polarization observations and optical spectrometry of a recent TDE candidate AT 2022fpx, alongside monitoring observations in optical, ultraviolet, and X-rays. The optical spectra of AT 2022fpx show Bowen fluorescence as well as highly ionized iron emission lines, which are characteristic of extreme coronal line emitters. Additionally, the source exhibits variable but low-polarized continuum emission at the outburst peak, with a clear rotation of the polarization angle. X-ray emission observed approximately 250 d after the outburst peak in the decay appear flare-like but is consistent with constant temperature blackbody emission. The overall outburst decay is slower than for typical TDEs, and resembles more the ones seen from Bowen fluorescence flares. These observations suggest that AT 2022fpx could be a key source in linking different long-lived TDE scenarios. Its unique characteristics, such as extreme coronal line emission, variable polarization, and delayed X-ray flare, can be attributed to the outer shock scenario or a clumpy torus surrounding the supermassive black hole. Further studies, especially in the context of multiwavelength observations, are crucial to fully understand the dynamics and emission mechanisms of these intriguing astrophysical events.
Properties of magnetic null points associated with X-class flares during solar cycle 24
Authors: Edgar R L , Régnier S 
Published: June 2024

ABSTRACT
Since the launch of the Solar Dynamics Observatory (SDO) in 2010 and throughout the solar cycle 24, the Sun has produced few tens of X-class flares, which are the most energetic solar events. Those flares are produced in regions where the magnetic flux/energy is large and the magnetic configurations are complex. To provide more insights into the flaring process, we investigate the properties of magnetic null points (MNPs) and their correlation with the energy release sites. During solar cycle 24, we identify 17 X-class flares satisfying selection criteria. From SDO/HMI magnetograms, we perform potential extrapolations around the peak time of the flare to access the 3D coronal magnetic field and thus investigate the existence of coronal MNPs. We then correlate the flaring sites with the existing MNPs using SDO/AIA 171 Å; EUV observations, and deduce their properties (sign, spine, and fan). Six active regions out of 10 possess at least one MNP which is stable and with large magnetic field gradients: this implies that 35 per cent of X-class flares are associated with an MNP; of which 87.5 per cent of MNPs are of positive type. The MNPs associated with the flare sites are predominantly located at a height between 0.5 and 2 Mm, and with a vertical/radial spine field line. We also find a slight correlation between the MNPs not associated with a flare and negative-type MNPs (55 per cent) within the active region. Regarding the physics of flares, the association between the enhanced intensity at the flaring site and an MNP represents about a third of the possible scenarios for triggering X-class flares.