bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chromenopyrazoles: Non‐psychoactive and Selective CB1 Cannabinoid Agonists with Peripheral Antinociceptive Properties
Authors: Cumella Jose , Hernández‐Folgado Laura , Girón Rocio , Sánchez Eva , Morales Paula , Hurst Dow P. , Gómez‐Cañas Maria , Gómez‐Ruiz Maria , Pinto Diana C. G. A. , Goya Pilar , Reggio Patricia H. , Martin María Isabel , Fernández‐Ruiz Javier , Silva Artur M. S. , Jagerovic Nadine 
Published: February 2012

AbstractThe unwanted psychoactive effects of cannabinoid receptor agonists have limited their development as medicines. These CB1‐mediated side effects are due to the fact that CB1 receptors are largely expressed in the central nervous system (CNS). As it is known that CB1 receptors are also located peripherally, there is growing interest in targeting cannabinoid receptors located outside the brain. A library of chromenopyrazoles designed analogously to the classical cannabinoid cannabinol were synthesized, characterized, and tested for cannabinoid activity. Radioligand binding assays were used to determine their affinities at CB1 and CB2 receptors. Structural features required for CB1/CB2 affinity and selectivity were explored by molecular modeling. Some compounds in the chromenopyrazole series were observed to be selective CB1 ligands. These modeling studies suggest that full CB1 selectivity over CB2 can be explained by the presence of a pyrazole ring in the structure. The functional activities of selected chromenopyrazoles were evaluated in isolated tissues. In vivo behavioral tests were then carried out on the most effective CB1 cannabinoid agonist, 13 a. Chromenopyrazole 13 a did not induce modifications in any of the tested parameters on the mouse cannabinoid tetrad, thus discounting CNS‐mediated effects. This lack of agonistic activity in the CNS suggests that this compound does not readily cross the blood–brain barrier. Moreover, 13 a can induce antinociception in a rat peripheral model of orofacial pain. Taking into account the negative results obtained with the hot‐plate test, the antinociception induced by 13 a in the orofacial test could be mediated through peripheral mechanisms.
A 2,6‐Disubstituted 4‐Anilinoquinazoline Derivative Facilitates Cardiomyogenesis of Embryonic Stem Cells
Authors: Shen Guofang , Hu Ying , Wu Jianwei , Jin Ke , Zhu Danyan , Zhang Yandong , Yu Yongping , Lou Yijia 
Published: February 2012

AbstractChemical approaches are widely used in directed differentiation of embryonic stem (ES) cells. In our search for novel lead compounds that could facilitate cardiomyogenesis of ES cells, we designed a two‐step screening system based on P19 embryonic carcinoma and mouse ES cells. Application of this system to a quinazoline compound library including 2,3‐disubstituted 8‐arylamino‐3H‐imidazo[4,5‐g]quinazolines and 2,6‐disubstituted 4‐anilinoquinazoline led us to the discovery of compound 62, which exhibits a stable cardiomyogenic effect on both P19 and mouse ES cells at a concentration of 0.1 μM. An EGFR inhibition assay and molecular docking studies confirmed 62 as a potent EGFR inhibitor with a tyrosine kinase IC50 value of 101 nM. However, major differences in cardiomyogenic activity were observed between iressa and 62, indicating that other molecular events are also involved in compound 62‐induced cardiomyogenesis of ES cells.
The combined predictive effect of patient characteristics and alliance on long‐term dynamic and interpersonal functioning after dynamic psychotherapy
Authors: Hersoug Anne Grete , Høglend Per , Gabbard Glen O. , Lorentzen Steinar 
Published: February 2012

On the basis of the well‐established association between early alliance and outcome, this exploratory study investigated the associations between the therapeutic alliance and long‐term outcome, 3 years after treatment termination. In addition to the early alliance, pre‐treatment patient characteristics and expectancies that were significantly related to early alliance were included in the statistical analyses. The data are from the First Experimental Study of Transference, a dismantling randomized clinical trial with long‐term follow‐up. One hundred out‐patients who sought psychotherapy due to depression, anxiety and personality disorders were treated. Alliance was measured with Working Alliance Inventory after session 7. Change was determined using linear mixed model analyses. The alliance alone had a significant impact on long‐term outcome of the predetermined primary outcome variables of the study: Psychodynamic Functioning Scales and Inventory of Interpersonal Problems. Contrary to common clinical wisdom, when the pre‐treatment patient variables were included, more personality disorder pathology was the strongest predictor of favourable outcome, over and above the effect of the alliance, which was no longer significant. Clinical implications are discussed. Copyright © 2012 John Wiley & Sons, Ltd.Key Practitioner MessagePatients with more personality pathology responded more favourably to long‐term relational dynamic psychotherapy than patients with less personality pathology.Patient characteristic had stronger effect on long‐term outcome, over and above the effect of alliance.In relational dynamic psychotherapy, it is important to focus on dysfunctional interpersonal problems, as they appear both in the transference and in the patients' day to day life outside therapy.The therapeutic task is to balance a forthright discussion of recurrent patterns of interpersonal difficulty with an empathic appreciation that these patterns are hard to change because of their longstanding entrenched nature.
Asymmetric requirement of surface epithelial β‐catenin during the upper and lower jaw development
Authors: Sun Ye , Teng Ian , Huo Randi , Rosenfeld Michael G. , Olson Lorin E. , Li Xiaokun , Li Xue 
Published: February 2012

AbstractBackground: Intercellular communication between epithelial and mesenchymal cells is central to mammalian craniofacial development. β‐catenin is the gateway of canonical Wnt signaling, one of the major evolutionarily conserved cell–cell communication pathways in metazoa. In this study, we report an unexpected stage‐ and tissue‐specific function of β‐catenin during mammalian jaw development. Results: Using a unique mouse genetic tool, we have discovered that epithelial β‐catenin is essential for lower jaw formation, while attenuation of β‐catenin is required for proper upper jaw development. Changes in β‐catenin in vivo alter major epithelial Fgf8, Bmp4, Shh, and Edn1 signals, resulting in partial transcriptional reprogramming of the neural crest‐derived mesenchyme, the primary source of jawbones. Conclusions: The Wnt/β‐catenin signal coordinates expression of multiple epithelial signals and has stage‐specific asymmetric functions during mammalian upper and lower jaw development. In addition, these findings suggest that evolutionary changes of the canonical Wnt/β‐catenin signaling pathway may lead to innovation of jaws. Developmental Dynamics 241:663–674, 2012. © 2012 Wiley Periodicals, Inc.
Synthesis and Characterization of Surface‐Functionalized Layered Titanate Nanosheets Using Lamellar Self‐Assembly as a Template
Authors: Nakagawa Keizo , Yamaguchi Kazuki , Yamada Keiji , Sotowa Ken‐Ichiro , Sugiyama Shigeru , Adachi Motonari 
Published: February 2012

AbstractThe synthesis of metal oxide nanosheets using a lamellar phase as a template effectively modified the nanosheets because surfactant molecules surround the entire surface of the nanosheets. Here, we show the development of layered titanate nanosheets with a lamellar mesostructure. The layered titanate nanosheet forms by using the lamellar self‐assembly of cationic dodecanediamine as a template and an electrostatic interaction between negatively charged titanate nanosheets and positively charged 1,12‐dodecanediamine during hydrothermal synthesis. This approach leads to titanate nanosheets with new properties such as visible light absorption and a high adsorption of cationic organic compounds, which results in the effective photodegradation of Rhodamine B under visible‐light irradiation. This approach has important implications for the use of metal oxide nanosheets in environmental and industrial applications.
New Linearly and Angularly Fused Quinazolinones: Synthesis through Gold(I)‐Catalyzed Cascade Reactions and Anticancer Activities
Authors: Patil Nitin T. , Lakshmi Pediredla G. V. V. , Sridhar Balasubramanian , Patra Sujata , Pal Bhadra Manika , Patra Chitta Ranjan 
Published: February 2012

AbstractA robust library‐based approach to new fused quinazolinones by the development of gold(I)‐catalyzed cascade reactions between 2‐aminobenzohydrazides and alkynoic acids is documented. Selected compounds were administered to lung (A549) and breast cancer cells (MDA‐MB‐231 and MCF‐7) in vitro and it was found that some successfully inhibited cell proliferation.
Triply Branched Viologen Stars: Synthesis and Polymerization by Peripheral Benzyl Coupling (Eur. J. Org. Chem. 5/2012)
Authors: Constantin Veronica‐Alina , Bongard Dirk , Walder Lorenz 
Published: February 2012

AbstractThe cover picture shows the synthesis of new star‐shaped oligoviologens (left to right), consisting of a trifold central branching unit and three linear branches (up to 5.8 nm long) of alternating benzyl (blue) and phenyl viologens (red). Up to 24 electrons can be injected into the viologen subunits at four well‐separated electrode potentials (green vertical region). The corresponding localized spin densities in a single short branch are shown in the grey region. Viologen stars with peripheral benzylic bromides are reductively cross‐linked to yield a polymer with persisting star subunits (brown region). The star‐shaped multielectron molecules are supposed to have potential applications as electron sponges, as switchable organic magnets, as nanometer‐sized components in composite nanomaterials, and so on. Details are discussed in the article by L. Walder et. al. on p. 913 ff. magnified image
Inorganic polymeric materials for passive fire protection of underground constructions
Authors: Sakkas Konstantinos , Nomikos Pavlos , Sofianos Alexandros , Panias Dimitrios 
Published: February 2012

SUMMARYProtection against fire for reinforced concrete constructions is of great importance worldwide. There is a general perception that concrete structures are incombustible and thus, they have good fire‐resistance properties. In a real fire incident, however, concrete can be subjected to excess temperatures causing severe spalling and serious damage to concrete structures with significant economic cost and high potential risk to human life safety. Although a variety of fire‐protection methods exist, there is always a need for the development of new materials with improved thermophysical properties and low cost. Inorganic polymeric materials are promising from this point of view. They are incombustible, combining excellent physical, chemical, mechanical and thermal properties with low production cost and significant environmental benefits. In this work, the thermophysical properties of ferronickel slag‐based inorganic polymeric materials are studied. The results from the laboratory scale experiments are promising and indicative of the large‐scale behavior of material. The effectiveness of this material has to be proved in large‐scale experiments at higher temperatures simulating several severe fire scenarios as well as under all kinds of mechanical loading before concluding for its applicability as a fire protection system. Copyright © 2012 John Wiley & Sons, Ltd.
Hyperparathyroidism–jaw tumor syndrome
Authors: Kutcher Matthew R. , Rigby Matthew H. , Bullock Martin , Trites Jonathan , Taylor S. Mark , Hart Robert D. 
Published: February 2012

AbstractBackgroundHyperparathyroidism–jaw tumor (HPT‐JT) syndrome is a rare autosomal dominant multiple tumor syndrome characterized by hyperparathyroidism due to single or multiple‐gland parathyroid tumor(s). Since it was first described in 1990, the genetics underlying the syndrome have been elucidated and typical clinical presentations are becoming clarified as literature describing this rare entity amasses.Methods and ResultsA 22‐year‐old man presented with a 2‐year history of fatigue, weight loss, nausea, and vomiting. Anemia workup indicated severe hypercalcemia. Investigations were consistent with a diagnosis of HPT‐JT. The patient underwent a total 4‐gland parathyroidectomy with single gland reimplantation.ConclusionHPT‐JT is a complex syndrome with phenotypic manifestations that can seem physiologically and temporally unrelated. The risk of parathyroid carcinoma is elevated in patients with HPT‐JT, necessitating rapid treatment and complete tumor resection to reduce the morbidity and mortality associated with intractable hypercalcemia due to local recurrence or metastatic disease. © 2012 Wiley Periodicals, Inc. Head Neck, 2012
Multimodality approach for advanced‐stage juvenile nasopharyngeal angiofibromas
Authors: Álvarez Fernando López , Suárez Vanessa , Suárez Carlos , Llorente José L. 
Published: February 2012

AbstractBackgroundJuvenile nasopharyngeal angiofibromas (JNAs) with significant skull base involvement and intracranial extension are challenging tumors. We evaluated our experience in the treatment of extensive JNAs through resection followed by radiosurgery.MethodsFrom 1999 to 2007, 10 advanced JNAs (Andrews grade IV) were treated by primary surgical resection followed by gamma knife radiosurgery of residual tumor. Tumor control and treatment morbidity were evaluated.ResultsSix months after radiosurgery and annually thereafter, an imaging study was done that revealed decrement in tumor size in 3 patients and no change in 7 patients, after a 3‐year minimum follow‐up. Clinically, patients are asymptomatic.ConclusionAn efficient strategy in the management of extensive JNAs is the use of a multimodality approach, in which surgical resection is followed by the treatment with radiosurgery in critical locations. These therapeutic schemes are safe and offer long‐term tumor control. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
Clinical value of endosonography in the assessment of laryngeal cancer
Authors: Kraft Marcel , Bruns Nina , Hügens‐Penzel Monika , Arens Christoph 
Published: February 2012

AbstractBackgroundEndosonography has been successfully used in staging gastrointestinal cancer, but its value is as yet undetermined in laryngology.MethodsThis prospective study includes 84 patients undergoing microlaryngoscopy for laryngeal cancer. The results of endosonography were compared with those of CT and MRI in the 76 surgical cases.ResultsIn the assessment of laryngal cancer, endosonography was superior to current imaging techniques, whereas CT and MRI showed similar results (accuracy of 89% vs 77% and 77%, respectively).ConclusionsThis study confirms that endosonography is highly effective in staging laryngeal cancer. Therefore, the latter may constitute a complementary diagnostic tool in these tumors and additionally may assist in choosing an adequate treatment. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
Toward human resource management in inter‐professional health practice: linking organizational culture, group identity and individual autonomy
Authors: Tataw David 
Published: February 2012

SUMMARYThe literature on team and inter‐professional care practice describes numerous barriers to the institutionalization of inter‐professional healthcare. Responses to slow institutionalization of inter‐professional healthcare practice have failed to describe change variables and to identify change agents relevant to inter‐professional healthcare practice. The purpose of this paper is to (1) describe individual and organizational level barriers to collaborative practice in healthcare; (2) identify change variables relevant to the institutionalization of inter‐professional practice at individual and organizational levels of analysis; and (3) identify human resource professionals as change agents and describe how the strategic use of the human resource function could transform individual and organizational level change variables and therefore facilitate the healthcare system's shift toward inter‐professional practice. A proposed program of institutionalization includes the following components: a strategic plan to align human resource functions with organizational level inter‐professional healthcare strategies, activities to enhance professional competencies and the organizational position of human resource personnel, activities to integrate inter‐professional healthcare practices into the daily routines of institutional and individual providers, activities to stand up health provider champions as permanent leaders of inter‐professional teams with human resource professionals as consultants and activities to bring all key players to the table including health providers. Copyright © 2012 John Wiley & Sons, Ltd.
Influence of skin aging effects on the skin surface profile and the correlated distribution of topically applied sunscreens
Authors: Gebauer Vera , Weigmann Hans‐Jürgen , Schanzer Sabine , Meinke Martina C. , Vergou Theognosia , Sterry Wolfram , Lademann Jürgen 
Published: February 2012

AbstractThe surface profile of human skin influences characteristically the distribution pattern of topically applied formulations and consequently the efficacy of sunscreens. The volumes of furrows and the spectroscopically determined factors of inhomogeneity are investigated for three sunscreens. A clear correlation between both measurands exists. The average values for younger (<32 years) and older (≥51 years) volunteers do not show statistically significant differences. Systematic variations found for the individual values are due to a reduced elasticity of the skin with age improving the homogeneity of the sunscreen distribution. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Studying photoprotective processes in the green alga Chlorella pyrenoidosa using nonlinear laser fluorimetry
Authors: Fadeev Victor V. , Gorbunov Maxim Y. , Gostev Timofey S. 
Published: February 2012

AbstractWe use an advanced fluorescence method of Nonlinear Laser Fluorimetry in combination with Fluorescence Induction and Relaxation technique to study the influence of excess‐light conditions on the physiological state of the green alga Chlorella pyrenoidosa. We demonstrate that zeaxanthin‐dependent non‐photochemical quenching leads to a significant increase in the rate constant of singlet‐singlet annihilation of chlorophyll a excited state, which suggests profound conformational changes in the light‐harvesting complexes of photosystem II. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Synthesis of a Furanosyl‐pyranone Derivative Related to the Tri‐O‐heterocyclic Core of Herbicidins
Authors: Hsu Ching‐Yun , Lee I‐Chi , Lico Larry S. , Uang Biing‐Jiun , Hung Shang‐Cheng 
Published: February 2012

AbstractA new compound that is structurally related to the undecose ring structure of herbicidins has been prepared. The synthesis of this novel furanosyl‐pyranone derivative was made possible through the regioselective reductive ring‐opening of a 3,5‐O‐benzylidene‐D‐xylofuranose and the hetero‐Diels—Alder reaction of an aldehyde and a Danishefsky‐type diene. The highly functionalized pyranone derivative can be a useful precursor for the synthesis of herbicidins.
Immobilization of laccase on itaconic acid grafted and Cu(II) ion chelated chitosan membrane for bioremediation of hazardous materials
Authors: Bayramoglu Gulay , Gursel Ihsan , Yilmaz Meltem , Arica Mehmet Yakup 
Published: February 2012

AbstractBACKGROUND: Chitosan membranes were formed through a phase inversion technique and then cross‐linked with epichlorohydrin (CHX). Heterogeneous graft copolymerization of itaconic acid (IA) onto membrane was carried out with different monomer concentrations (CHX‐g‐p(IA)). The membrane properties such as equilibrium swelling ratio, porosity, and contact angle were measured, together with analysis by scanning electron microscopy (SEM), energy dispersive analysis of X‐rays (EDAX), atomic force microscopy (AFM), and Fourier transform infrared (FTIR) spectroscopy.RESULTS: The Cu(II) ion incorporated membranes (i.e. CHX‐g‐p(IA)‐Cu(II)) were used for reversible immobilization of laccase using CHX‐g‐p(IA) membrane as a control system. Maximum laccase adsorption capacities of the CHX‐g‐p(IA) and CHX‐g‐p(IA)‐Cu(II) membranes (with 9.7% grafting yield) were found to be 6.3 and 17.6 mg mL−1 membrane at pH 4.0 and 6.0, respectively. The Km value for immobilized laccase on CHX‐g‐p(IA)‐Cu(II) (4.16 × 10−2 mmol L−1) was 2.11‐fold higher than that of free enzyme (1.97 × 10−2 mmol L−1). Finally, the immobilized laccase was used in a batch system for degradation of three different dyes (Reactive Black 5, RB5; Cibacron Blue F3GA, CB; and Methyl Orange, MO). The immobilized laccase on CHX‐g‐p(IA)‐Cu(II) membrane was more effective for removal of MO dye than removal of CB and RB5 dyes.CONCLUSION: Flexibility of the enzyme immobilized grafted polymer chains is expected to provide easy reaction conditions without diffusion limitation for substrate dye molecules and their products. The support described, prepared from green chemicals, can be used for the immobilization of industrially important enzymes. Copyright © 2012 Society of Chemical Industry
Equilibrium and dynamic studies of the removal of As(III) and As(V) from contaminated aqueous systems using a functionalized biopolymer
Authors: Gupta Anjali , Yunus M. , Sankararamakrishnan Nalini 
Published: February 2012

AbstractBACKGROUND: A study of the removal of arsenic from a sample of actual groundwater using crosslinked xanthated chitosan is described.RESULTS: Removal of As(III) and As(V) was studied at pH 7.5 under equilibrium and dynamic conditions. The equilibrium data were fitted to Langmuir and Freundlich adsorption models and the various model parameters evaluated. The monolayer adsorption capacity from the Langmuir model for xanthated chitosan flakes (XCF) (As(V) 20.0 ± 0.56 mg g−1; As(III) 33.0 ± 0.32 mg g−1) were lower than obtained for xanthated chitosan granules (XCB) (As(V) 36.0 ± 0.52 mg g−1; As(III) 48.0 ± 0.45 mg g−1). Adsorption of As (V) was unaffected by the presence of other anions while in the case of As(III) the presence of sulfate and silicate caused a 26.5–50.9% decrease in adsorption. A sample (940 bed volumes) of a groundwater spiked with 200 µg L−1 As(V) treated with XCF in column experiments reduced the arsenic concentration to < 10 µg L−1. The adsorbent was also successfully applied for the removal of total inorganic arsenic down to < 10 µg L−1 from real samples of arsenic‐contaminated groundwater.CONCLUSION: Xanthated chitosan was an efficient adsorbent for the removal of both forms of arsenic from groundwater under near neutral conditions. The presence of sulfur and the amino groups resulted in increased adsorption capacity of the sorbent. Copyright © 2012 Society of Chemical Industry
Measuring implicit psychological constructs in organizational behavior: An example using psychological capital
Authors: Harms Peter D. , Luthans Fred 
Published: February 2012

SummaryImplicit psychological constructs are effective predictors of behavioral outcomes but are rarely used in organizational settings because of real or imagined problems with measurement validity and administration. To address these concerns, we present a means of assessing implicit constructs quickly and easily by using psychological capital as an example. Copyright © 2012 John Wiley & Sons, Ltd.