bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing the Effectiveness of Computerized Adverse Drug Event Monitoring Systems to Enhance Clinical Decision Support for Hospitalized Patients
Authors: Petratos G. N. , Kim Y. , Evans R. S. , Williams S. D. , Gardner R. M. 
Published: September 2010

Summary
Objective: Performance of computerized adverse drug event (ADE) monitoring of electronic health records through a prospective ADE Monitor and ICD9-coded clinical text review operating independently and simultaneously on the same patient population for a 10-year period are compared. Requirements are compiled for clinical decision support in pharmacy systems to enhance ADE detection.
Methods: A large tertiary care facility in Utah, with a history of quality improvement using its advanced hospital information system, was leveraged in this study. ICD9-based review of clinical charts (ICD9 System) was compared quantitatively and qualitatively to computer-assisted pharmacist-verified ADEs (ADE Monitor). The capture-recapture statistical method was applied to the data to determine an estimated prevalence of ADEs.
Results: A total estimated ADE prevalence of 5.53% (13,420/242,599) was calculated, with the ICD9 system identifying 2,604 or 19.4%, and the ADE monitor 3,386 or 25.2% of all estimated ADEs. Both methods commonly identified 4.9% of all estimated ADEs and matched 62.0% of the time, each having its strength in detecting a slightly different domain of ADEs. 70% of the ADE documentation in the clinical notes was found in the discharge summaries.
Conclusion: Coupled with spontaneous reporting, computerized methods account for approximately half of all ADEs that can currently be detected. To enhance ADE monitoring and patient safety in a hospitalized setting, pharmacy information systems should incorporate prospective structuring and coding of the text in clinical charts and using that data alongside computer-generated alerts of laboratory results and drug orders. Natural language processing can aid computerized detection by automating the coding, in real-time, of physician text from clinical charts so that decision support rules can be created and applied. New detection strategies and enhancements to existing systems should be researched to enhance the detection of ADEs since approximately half are not currently detected.
Synthesis and Antioxidant Activity of New Pyridines Containing Gallate Moieties
Authors: El‐Ebiary Nora M. A. , Swellem Randa H. , Mossa Abdel‐Tawab H. , Nawwar Galal A. M. 
Published: September 2010

AbstractPyridines containing the galloyl moiety have been prepared utilizing 4‐acetyl pyrogallol. In addition, fused pyridines were synthesized from the obtained pyridines via further chemical transformations. The results indicated that compound 4a showed stronger DPPH scavenging activity than the other compounds, and the scavenging effect decreased in the following order 4a > t‐BHQ > 2a > 2b > 3a > 3b > 4b. Accordingly, other antioxidant assays were conducted for 4a. The results suggested that compound 4a could be a good antioxidant candidate. The absence of mortality of rats receiving 5000 mg/kg body weight of 4a as single oral dose may indicate that it could be a safe antioxidant and may be used for further studies.magnified image
Zinc and reproduction: effects of zinc deficiency on prenatal and early postnatal development
Authors: Uriu‐Adams Janet Y. , Keen Carl L. 
Published: September 2010

AbstractA large body of evidence supports the concept that human pregnancy outcome is significantly influenced by the nutritional status of the mother. The consumption of “poor diets” has been associated with an increased risk for pregnancy complications, including gross structural birth defects, prematurity, low birth weight, and an increased risk for neurobehavioral and immunological abnormalities after birth. Forty‐four years ago, zinc deficiency in mammals was shown to be teratogenic. Maternal zinc deficiency produces effects ranging from infertility and embryo/fetal death, to intrauterine growth retardation and teratogenesis. Postnatal complications of maternal zinc deficiency can also occur, and include behavioral abnormalities, impaired immunocompetence, and an elevated risk for high blood pressure in the offspring. It has been suggested that developmental zinc deficiency in humans can present a significant challenge to the conceptus, increasing the risk for numerous defects. Developmental zinc deficiency can occur through multiple pathways, and the concept that acute phase response‐induced changes in maternal zinc metabolism may be a common cause of embryonic and fetal zinc deficiency is presented. Potential mechanisms underlying the teratogenic effects of zinc deficiency are reviewed. The potential value of maternal zinc supplementation in high risk pregnancies is discussed.Birth Defects Res (Part B)89:313–325, 2010. © 2010 Wiley‐Liss, Inc.
Thermophilic laccase from xerophyte species Opuntia vulgaris
Authors: Kumar Gali Nirmal , Srikumar Kotteazeth 
Published: September 2010

AbstractTwo laccase temperature isoforms capable of oxidizing phenolic compounds to quinones were isolated and purified to homogeneity from the cladodes of the xerophyte species Opuntia vulgaris. These catalytically active proteins exhibit apparent molecular masses of 137 and 90 kDa. Under reducing conditions, both isoforms yielded a subunit molecular mass of 43 kDa, suggesting that the enzyme is a multimer of the 43 kDa subunit. The 137 kDa isoform when heated at 80°C for 3min generated three polypeptide bands on activity stained polyacrylamide gels exhibiting 137, 90 and 43 kDa molecular forms. All isoforms of the enzyme exhibited an optimum pH of 10 when 2,6‐dimethoxyphenol was used as a substrate. The optimum temperature of the 137 kDa enzyme form was noted to be 80°C and that of the 90 kDa enzyme form was 70°C. Denaturation kinetics of both the laccase isoforms carried out at their respective optimum temperatures for 30 min exhibited enzyme activity in excess of their t1/2 values throughout the assay period. The Km for the 137 kDa form was determined to be 2.2 ± 0.3 mm and the Vmax was 2.8 ± 0.2 IU/mL. These high temperature stable laccase isoforms having alkaline pH optima can find significant industrial use. Copyright © 2010 John Wiley & Sons, Ltd.
Rapid ultraperformance liquid chromatography–tandem mass spectrometry method for quantification of oxcarbazepine and its metabolite in human plasma
Authors: Bhatt Mitesh , Shah Sanjay , Shivprakash  
Published: September 2010

AbstractA rapid and sensitive ultraperformance liquid chromatography tandem mass spectrometry assay was developed for the simultaneous analysis of oxcarbazepine and its main metabolite in human plasma. The assay involves a simple solid‐phase extraction procedure of 0.3 mL of human plasma and analysis was performed on a triple‐quadrupole tandem mass spectrometer in multiple reaction monitoring mode via electrospray ionization. Separation was achieved on an Acquity UPLC™ BEH C18 column (50 × 2.1 mm, i.d., 1.7 µm) with isocratic elution at a flow‐rate of 0.25 mL/min and imipramine was used as the internal standard. The standard calibration curve was linear over the range 9.580–5070.205 ng/mL for oxcarbazepine (OXC) and 19.444–10290.800 ng/mL for 10,11‐dihydro‐10‐hydroxycarbamazepine (MHD), expressed by the linear correlation coefficient r2, which was better than 0.995 for OXC and MHD. The intra‐ and inter‐day precision and accuracy of the quality control samples were within 10.0%. The recoveries were 81.0, 89.6 and 66.6% for OXC, MHD and imipramine, respectively. The total run time was 1.5 min only for each sample, which makes it possible to analyze more than 350 samples per day. Copyright © 2010 John Wiley & Sons, Ltd.
ChemInform Abstract: Isomerization of PO‐ 3×(H2O)n Clusters to H2PO‐ 4×(H2O)n‐1: Transition States and Barrier Heights
Authors: MA B. , XIE Y. , SHEN M. , VON RAGUE SCHLEYER P. , SCHAEFER H. F. III 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reactions of Beryllium Atoms with Hydrogen. Matrix Infrared Spectra of Novel Product Molecules.
Authors: TAGUE T. J. JUN. , ANDREWS L. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electrochemical Intercalation of Oxygen in La2NiO4+x (0 ≤ x . ltoreq. 0.145).
Authors: DICARLO J. F. , YAZDI I. , BHAVARAJU S. , JACOBSON A. J. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Osmium Tetrafluoride Dioxide, cis‐OsO2F4.
Authors: CHRISTE K. O. , DIXON D. A. , MACK H. G. , OBERHAMMER H. , PAGELOT A. , SANDERS J. C. P. , SCHROBILGEN G. J. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structure of 1,1,3,3,5,5‐Hexaphenyl‐1,3,5‐trisiloxane‐1,5‐diol
Authors: BEHBEHANI H. , BRISDON B. J. , MAHON M. F. , MOLLOY K. C. , MAZHAR M. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Receptors for Oxo Acids: Effects of Intra‐Ion‐Pair Hydrogen Bonding on Acid‐Base Equilibria.
Authors: MANABE K. , OKAMURA K. , DATE T. , KOGA K. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Optically Active 4‐Hydroxymandelic Acid and Derivatives via Regio‐ and Stereoselective Friedel‐Crafts Alkylation.
Authors: BIGI F. , SARTORI G. , MAGGI R. , CANTARELLI E. , GALAVERNA G. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regio‐ and Enantioselective Hydrosilylation of 1‐Arylalkenes by Use of Palladium‐MOP Catalyst.
Authors: UOZUMI Y. , KITAYAMA K. , HAYASHI T. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Directed Metalation/Ligand Coupling Approach to the Enantioselective Synthesis of 1,1′‐Binaphthyls.
Authors: BAKER R. W. , POCOCK G. R. , SARGENT M. V. , TWISS E. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chiral Phosphorus Ligands for the Asymmetric Conjugate Addition of Organocopper Reagents.
Authors: ALEXAKIS A. , FRUTOS J. , MANGENEY P. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Two Enantioselective Syntheses of the Diol Precursor of the Biologically Most Active Isomer of an Insect Growth Regulator.
Authors: BUSER H.‐P. , SPINDLER F. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Strategies for Enantioselective Syntheses of 1‐Alkyl‐ and 1,4‐ Dialkyl‐1,2,3,4‐tetrahydroisoquinolines: Diastereoselective Additions of Nucleophiles and Electrophiles to Isoquinoline Mediated by an Easily Resolved and Recycled Chiral Transition Metal Auxiliary.
Authors: RICHTER‐ADDO G. B. , KNIGHT D. A. , DEWEY M. A. , ARIF A. M. , GLADYSZ J. A. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Synthesis by Enzymatic Hydrolysis of Prochiral Dienol Diacetate.
Authors: DUHAMEL P. , RENOUF P. , CAHARD D. , YEBGA A. , POIRIER J.‐M. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Effect of Substituents on Phenol‐isocyanate Reaction
Authors: KOTHANDARAMAN H. , NASAR A. S. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Reaction of Perfluoro‐2,5‐diazahexane‐2,5‐dioxyl with Alkenes.
Authors: GREEN M. J. , TIPPING A. E. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Free‐Radical Approach to the Synthesis of Fluorine‐Substituted Cyclic Compounds. Cyclization Reactions of Trifluoromethyl‐ and Difluoromethylene‐Substituted Carbon Radicals.
Authors: MORIKAWA T. , UEJIMA M. , KOBAYASHI Y. , TAGUCHI T. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regioselective Free Radical Cyclization: A General Method for the Synthesis of the Spiro(4.4)nonane System of Fredericamycin A.
Authors: RAO A. V. R. , SINGH A. K. , REDDY K. M. , RAVIKUMAR K. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel Photoreductive Cyclization of 1‐Aryl‐2‐methylpropane‐1,3‐diones.
Authors: YOSHIOKA M. , ISHIZUKA N. , SANO A. , KUWABARA S. , YOKOMORI Y. , HASEGAWA T. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Photorearrangements of Acyclic Conjugated Enynes: A Photochemical Analogue of the Bergman Rearrangement.
Authors: ZHENG M. , DIRICO K. J. , KIRCHHOFF M. M. , PHILLIPS K. M. , CUFF L. M. , JOHNSON R. P. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Photochemical Electrocyclization of Perfluoro‐E,Z,E‐4,5‐dimethyl‐2,4,6‐ octatriene.
Authors: DOLBIER W. R. JUN. , PALMER K. W. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electrochemical Reduction Behavior of 1‐Amino‐9,10‐anthraquinone
Authors: REDDY G. S. , REDDY C. R. , REDDY S. J. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Effective PQQ Inhibition by Alkynyl and Aryl Mono‐ and Diiodonium Salts.
Authors: GALLOP P. M. , PAZ M. A. , FLUECKIGER R. , STANG P. J. , ZHDANKIN V. V. , TYKWINSKI R. R. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Interaction of Perfluorocarbons with Carbon.
Authors: WEIGERT F. J. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemical and Electrochemical Synthesis of Some Substituted N,N′‐Diacyl‐ p‐phenylenediamines.
Authors: SUPRINA M. , VORKAPIC‐FURAC J. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 1,ω‐Perfluoroalkylation of Aromatics via Bis‐Decarboxylation of Perfluorodicarboxylic Acids with XeF2.
Authors: BREL V. K. , UVAROV V. I. , ZEFIROV N. S. , STANG P. J. , CAPLE R. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Palladium Catalyzed Chemoselective Cleavage of β‐Propargyloxy‐. alpha.,β‐Unsaturated Esters: Approach to γ‐Protected Hydroxy‐β‐Ketoesters.
Authors: SARIN G. S. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 1,1,4,4‐Tetranitro‐2,3‐butanediol and Its Derivatives. Part 5. Reaction of 1,1,4,4‐Tetranitro‐2,3‐butanediol with N‐(Methoxymethyl)‐2‐ fluoro‐2,2‐dinitroethylamine. Synthesis and Crystal Structure of 1,12‐ Difluoro‐1,1,3,5,5,8,8,10,12,12‐decanitro‐3,10‐diazadodecane‐6,7‐diol Dinitrate.
Authors: FEDOROV B. S. , GOLOVINA N. I. , ARAKCHEEVA V. V. , SHILOV G. V. , ATOVMYAN L. O. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient Electrophile‐Assisted Homoconjugate Addition of Triphenylphosphine to a Cyclopropyl Ketone.
Authors: LEE P. H. , KIM J. S. , HAN I.‐S. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Studies on Synthesis and Antimicrobial Evaluation of Some New Thiophenol Derivatives.
Authors: BHATT K. N. , DAVE A. M. , DESAI N. C. , UNDAVIA N. K. , TRIVEDI P. B. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel Sulfimides.
Authors: KOHRT E. , HARTKE K. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Local Anesthetic Activity of Some Derivatives of N,N‐ Diethyl‐2‐(2‐alkoxyphenylcarbamoyloxy)bornan‐3‐ylmethylammonium Chlorides.
Authors: GREGAN F. , KETTMANN V. , NOVOMESKY P. , RACANSKA E. , SVEC P. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.