bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reorganization of Snowfall beneath Cloud Top within the Comma Head Region of Two Extreme U.S. East Coast Winter Cyclones
Authors: Janiszeski Andrew , Rauber Robert M. , Jewett Brian F. , Zaremba Troy J. 
Published: June 2024

Abstract
This paper examines ice particle reorganization by three-dimensional horizontal kinematic flows within the comma head regions of two U.S. East Coast winter storms and the effect of reorganization on particle concentrations within snowbands in each storm. In these simplified experiments, the kinematic flows are from the initialization of the HRRR model. Ice particles falling through the comma head were started from either 9-, 8-, or 7-km altitude, spaced every 200 m, and were transported north or northwest, arriving within the north or northwest half of the primary snowband in each storm. The greatest particle concentration enhancement within each band was a factor of 2.32–3.84 for the 16–17 December 2020 storm and 1.76–2.32 for the 29–30 January 2022 storm. Trajectory analyses for particles originating at 4 km on the southeast side of the comma head beneath the dry slot showed that this region supplied particles to the south side of the band with particle enhancements of factor of 1.36–2.08 for the 16–17 December 2020 storm and 1.04–2.16 for the 29–30 January 2022 storm. Snowfall within the bands had two source regions: 1) on the north/northwestern side, from ice particles falling from the comma head, and 2) on the southeastern side, from particles forming at or below 4-km altitude and transported northwestward by low-level flow off the Atlantic. While the findings give information on the source of particles in the bands, they do not definitively determine the cause of precipitation banding since other factors, such as large-scale ascent and embedded convection, also contribute to snow growth.

Significance Statement
Wintertime storms along the east coast of North America can produce heavy snowfall, high winds, coastal flooding, and cold temperatures, resulting in major economic impacts within the northeast U.S. urban corridor. The heaviest snowfall typically occurs within snowbands, elongated narrow regions identifiable by high reflectivity on radar. This paper examines the potential sources of the ice particles contributing to the snowbands and how the flow fields throughout the storm can contribute to enhanced particle concentrations within the bands.
Development of HFC Blowing Agents. Part II: Expanded Polystyrene Insulating Boards
Authors: Albouy Arnaud , Roux Jean-Denis , Mouton Denis , Wu Jinhuang 
Published: June 2024

The development of HFCs as blowing agents for rigid polyurethane foams has previously been reported11’. In this second paper, it will be seen that the Montreal Protocol and its subsequent reviews have also presented a challenge for the extruded expanded polystyrene (XPS) foam industry. CFC-12 has long been the main blowing agent in that application due to its unique properties such as non-flammability, non-toxicity, low thermal conductivity and good processability. In developed countries, the rapid phase-out of CFC-12 was made possible due to the availability of HCFCs. HCFC-142b, pure or in blends with HCFC-22 or ethyl chloride, has now become the reference blowing agent for XPS insulating boards world wide owing to its superior properties. This paper will discuss the current situation by providing some information about properties commonly found in laminated boards. A theoretical model is used to simulate their long term behaviour, especially thermal insulation. Using this theoretical model and available data, it is possible to gain an insight into foam performance that can be achieved by zero ozone depletion potential substitutes such as HFCs and carbon dioxide. HFC-134a appears to be the leading candidate particularly when the thermal insulation is needed.
Diagnosis of post-thrombotic syndrome: International union of phlebology (UIP) survey of medical specialists
Authors: Xu Nuo , Siriwardene Manisha , Naidu Nikita , Connor David E , Davies Alun H , Gloviczki Peter , Meissner Mark H , Parsi Kurosh 
Published: June 2024

Objective To review the current approaches to the diagnosis of Post-Thrombotic Syndrome (PTS) and to evaluate the potential need for a diagnostic tool. Method Medical specialists were invited to participate in an online survey of their current approaches to the diagnosis and management of PTS, including the use of scoring systems, diagnostic imaging techniques and the extent the practitioner reviews the patient’s venous history. Results 502 participants completed the survey. Over 80% obtained imaging reports to confirm a history of deep vein thrombosis (DVT). 72% of participants always obtained an up-to-date duplex ultrasound for PTS diagnosis. Over 50% did not use a scoring system for either PTS diagnosis or management. 65% of the participants agreed that a new system for PTS diagnosis should be devised. Conclusion Heterogeneity was observed in methods of diagnosing PTS by medical practitioners with frequent use of medical imaging studies and moderate use of scoring systems. Development of a new diagnostic tool for PTS should be considered for future studies.
Esketamine combined with a mindfulness-based intervention for individuals with alcohol problems
Authors: Gent Emily M , Bryan Joshua W , Cleary Maisy A , Clarke Tegan I , Holmwood Harry D , Nassereddine Rania O , Salway Chris , Depla Simon , Statton Sarah , Krecké Joy , Morgan Celia JA 
Published: June 2024

Background: Alcohol use disorder (AUD) is a major public health issue, posing harmful consequences for individuals and society. Recent advances in addiction research have highlighted the therapeutic potential of ketamine-assisted therapy for AUD. However, the exact mechanisms underlying its effectiveness remain unknown. Aims: This double-blind, pilot study aimed to investigate esketamine combined with mindfulness-based intervention (MBI) to examine whether esketamine enhances engagement in MBI for individuals with alcohol misuse problems and whether enhanced engagement has any impact on alcohol-related outcomes. Methods: In all, 28 individuals with alcohol problems were randomly assigned to receive sublingual esketamine hydrochloride (AWKN002: 115.1 mg) or vitamin C (placebo) in an oral thin film and took part in 2 weeks of daily MBI. Participants were assessed on various self-report measures, including mindfulness, engagement in MBI (physical and psychological), alcohol cravings and consumption. Results: Esketamine enhanced psychological engagement with a daily MBI, compared to placebo, and led to transient decreases in alcohol cravings. Esketamine also resulted in significantly greater mystical experiences and dissociative states compared to placebo. Conclusions: The findings suggest that esketamine may improve treatment outcomes when combined with mindfulness-based therapies through its ability to increase engagement with meditative practice.
A reproducible method for evaluating the degree and direction of overstuffing of the humeral head component in anatomic total shoulder arthroplasty
Authors: Panther Eric J , Hao Kevin A , Patrick Matthew R , King Joseph J , Wright Thomas W , Struk Aimee M , Wright Jonathan O , Schoch Bradley S 
Published: June 2024

Background Improper sizing of the humeral head component in anatomic total shoulder arthroplasty (ATSA) can overstuff the joint, potentially compromising outcomes. The purpose of this study was to validate a novel method of evaluating glenohumeral joint overstuffing in which superoinferior and mediolateral overstuffing can be evaluated independently relative to the native humeral anatomy. Methods We identified 25 patients who underwent ATSA and the best Grashey radiograph taken within 1 year of follow-up was assessed using our proposed technique. First, a circle overlaying the implanted humeral head was made. Then, Iannotti's Perfect Circle (IPC) was drawn as originally described. Measurements of superior and medial overstuffing were made using our proposed axes. Inter-rater reliability was assessed by computing interclass correlation coefficients (ICC) using a one-way model. Measurements were summarized as the mean and range, with positive values denoting overstuffing. Results The inter-rater reliability for all measurements was excellent (ICC > 0.9). Compared to our method, the IPC method would have missed 77% of overstuffed cases. Conclusion We present a reproducible method to assess glenohumeral joint overstuffing in ATSA. This technique addresses limitations of other methods that underestimate overstuffing. Further study is needed to establish a clinically significant value of overstuffing based on the proposed method.
Association of Patient-Surgeon and Patient–Physical Therapist Relationships With Return to Sports After ACL Reconstruction: The Untested Dimension in Outcome Assessments
Authors: Moussa Mohamad K. , Lefèvre Nicolas , Valentin Eugénie , Khalaf Zeinab , Meyer Alain , Grimaud Olivier , Bohu Yoann , Gerometta Antoinne , Khiami Frederic , Hardy Alexandre 
Published: June 2024

Background: The Quality of Patient-Surgeon Relationship (QPASREL) is an 11-item questionnaire developed and validated to assess the relationship between practitioners and patients on recovery and return to work after surgery. Purpose: To evaluate the association of patient-surgeon relationship (PSR) and patient-physical therapist relationship (PPR), as measured by QPASREL, with a patient's return to sports (RTS) after anterior cruciate ligament reconstruction (ACLR). Study Design: Case-control study; Level of evidence, 3. Methods: This study targeted patients who underwent primary ACLR at a specialized sports surgery referral center between January and May 2021. Patients who had revision surgery, multiligamentous knee injury, and sedentary status were excluded from the study. Patients were grouped based on ability to RTS at the preinjury level 1 year postoperatively (RTS group and no-RTS group). The primary outcome was rate of RTS at 1 year postoperatively, and the primary dependent variables were the quality of PSR and PPR as measured by QPASREL scores at 6-month intervals. Secondary outcomes were the correlation and discriminative capacity of the QPASREL compared with the Anterior Cruciate Ligament–Return to Sport After Injury (ACL-RSI) scores (collected at 6-month intervals). Results: The study included 243 patients. Patients in the RTS group exhibited a higher mean PPR QPASREL score (36.6 ± 5.1) compared with no-RTS patients (34.8 ± 5.2; P = .01) as well as a higher mean PSR score (35.7 ± 5.1) compared with no-RTS patients (33.8 ± 5.9; P = .01). Multivariate analysis showed that every 5-point increase in the QPASREL scores for PPR and PSR resulted in a 39% (odds ratio [OR] = 1.39; P = 0.014) and 35% (OR = 1.35, P = 0.021) increased odds of RTS, respectively. A weak yet positive correlation was found between QPASREL and ACL-RSI. The predictive capacity of the QPASREL (area under the curve [AUC] = 0.60 for PPR and 0.61 for PSR), although significant, was less powerful compared with that of the ACL-RSI (AUC = 0.73). Conclusion: The quality of the PPR and PSR, as measured by QPASREL scores, demonstrated a significant association with RTS rates at 1 year after ACLR. A weak yet positive correlation was found between QPASREL and ACL-RSI.
How I treat bleeding in hereditary hemorrhagic telangiectasia
Authors: Al-Samkari Hanny 
Published: June 2024

Abstract
Hereditary hemorrhagic telangiectasia (HHT; Osler-Weber-Rendu disease) affects 1 in 5000 persons, making it the second most common inherited bleeding disorder worldwide. Telangiectatic bleeding, primarily causing recurrent epistaxis and chronic gastrointestinal bleeding, is the most common and most important manifestation of this multisystem vascular disorder. HHT-associated bleeding results in substantial psychosocial morbidity and iron deficiency anemia that may be severe. Although there remain no regulatory agency–approved therapies for HHT, multiple large studies, including randomized controlled trials, have demonstrated the safety and efficacy of antifibrinolytics for mild-to-moderate bleeding manifestations and systemic antiangiogenic drugs including pomalidomide and bevacizumab for moderate-to-severe bleeding. This has led to a recent paradigm shift away from repetitive temporizing procedural management toward effective systemic medical therapeutics to treat bleeding in HHT. In this article, 4 patient cases are used to illustrate the most common and most challenging presentations of HHT-associated bleeding that hematologists are likely to encounter in daily practice. Built on a framework of published data and supported by extensive clinical experience, guidance is given for modern evidence–based approaches to antifibrinolytic therapy, antiangiogenic therapy, and iron deficiency anemia management across the HHT disease severity spectrum.
Efficacy of intramedullary bridge fixation for midshaft clavicle fractures: a retrospective analysis of a novel technique
Authors: Ma Tianyong , Su Huan , Lu Yihong , Chen Junping , Tan Weiyuan , Lei Fang , Wang Dewei 
Published: June 2024

Abstract
Background
The aim of this study was to explore the efficacy of a novel intramedullary fixation technique using the ortho-bridge system (OBS) for midshaft clavicle fractures.

Methods
A total of 63 patients were included in this study: 35 underwent plate internal fixation (LP group) and 28 underwent OBS intramedullary fixation (OBS group). Surgical time, intraoperative blood loss, incision length, fracture healing time, removal of the internal fixation agent, visual analog scale (VAS) score for shoulder pain, Constant–Murley shoulder score and complication occurrence were compared between the two groups.

Results
Preoperative general data, such as sex, age and fracture type, were not significantly different between the two groups (P > 0.05). However, the OBS group exhibited better outcomes than the LP group exhibited in terms of surgical time, intraoperative blood loss and total incision length (P < 0.05). Additionally, the OBS group exhibited a significantly shorter fracture healing time and internal-fixation removal time than the LP group exhibited (P < 0.05). The VAS scores on postoperative day 1, week 1, month 1 and month 3 were lower in the OBS group than in the LP group (P < 0.05). Furthermore, the Constant–Murley shoulder scores at 1, 3, and 6 months postoperatively were higher in the OBS group than in the LP group (P < 0.05), with no significant difference at 1 year after surgery (P > 0.05). None of the patients in the OBS group experienced scarring of the surgical incision, and 6 patients in the LP group experienced scarring of the surgical incision. Finally, the complication incidence in the OBS group was lower than that in the LP group.

Conclusion
For midshaft clavicle fractures, OBS intramedullary fixation is better than locking-plate internal fixation because it led to less trauma, a faster recovery, better efficacy, and better esthetic outcomes and comfort. Therefore, this technique may have potential as a novel treatment for midshaft clavicle fractures.
Level of evidence: III, retrospective observational study.
Transcriptomic analysis reveals the regulatory mechanisms of messenger RNA (mRNA) and long non-coding RNA (lncRNA) in response to waterlogging stress in rye (Secale cereale L.)
Authors: Bimpong Daniel , Zhao Lili , Ran Mingyang , Zhao Xize , Wu Cuicui , Li Ziqun , Wang Xue , Cheng Ling , Fang Zhengwu , Hu Zanmin , Fan Chengming , Gyebi-Nimako Bernard , Luo Yirou , Wang Shuping , Zhang Yingxin 
Published: June 2024

Abstract
Background
Waterlogging stress (WS) negatively impacts crop growth and productivity, making it important to understand crop resistance processes and discover useful WS resistance genes. In this study, rye cultivars and wild rye species were subjected to 12-day WS treatment, and the cultivar Secale cereale L. Imperil showed higher tolerance. Whole transcriptome sequencing was performed on this cultivar to identify differentially expressed (DE) messenger RNAs (DE-mRNAs) and long non-coding RNAs (DE-lncRNAs) involved in WS response.

Results
Among the 6 species, Secale cereale L. Imperil showed higher tolerance than wild rye species against WS. The cultivar effectively mitigated oxidative stress, and regulated hydrogen peroxide and superoxide anion. A total of 728 DE-mRNAs and 60 DE-lncRNAs were discovered. Among these, 318 DE-mRNAs and 32 DE-lncRNAs were upregulated, and 410 DE-mRNAs and 28 DE-lncRNAs were downregulated. GO enrichment analysis discovered metabolic processes, cellular processes, and single-organism processes as enriched biological processes (BP). For cellular components (CC), the enriched terms were membrane, membrane part, cell, and cell part. Enriched molecular functions (MF) terms were catalytic activity, binding, and transporter activity. LncRNA and mRNA regulatory processes were mainly related to MAPK signaling pathway-plant, plant hormone signal transduction, phenylpropanoid biosynthesis, anthocyanin biosynthesis, glutathione metabolism, ubiquitin-mediated proteolysis, ABC transporter, Cytochrome b6/f complex, secondary metabolite biosynthesis, and carotenoid biosynthesis pathways. The signalling of ethylene-related pathways was not mainly dependent on AP2/ERF and WRKY transcription factors (TF), but on other factors. Photosynthetic activity was active, and carotenoid levels increased in rye under WS. Sphingolipids, the cytochrome b6/f complex, and glutamate are involved in rye WS response. Sucrose transportation was not significantly inhibited, and sucrose breakdown occurs in rye under WS.

Conclusions
This study investigated the expression levels and regulatory functions of mRNAs and lncRNAs in 12-day waterlogged rye seedlings. The findings shed light on the genes that play a significant role in rye ability to withstand WS. The findings from this study will serve as a foundation for further investigations into the mRNA and lncRNA WS responses in rye.
Genome-wide identification, molecular evolution and expression analysis of the B-box gene family in mung bean (Vigna radiata L.)
Authors: Yin Lili , Wu Ruigang , An Ruilan , Feng Yaxin , Qiu Yaqi , Zhang Meiling 
Published: June 2024

Abstract
Background
Mung bean (Vigna radiata L.) is an important warm-season grain legume. Adaptation to extreme environmental conditions, supported by evolution, makes mung bean a rich gene pool for stress tolerance traits. The exploration of resistance genes will provide important genetic resources and a theoretical basis for strengthening mung bean breeding. B-box (BBX) proteins play a major role in developmental processes and stress responses. However, the identification and analysis of the mung bean BBX gene family are still lacking.

Results
In this study, 23 VrBBX genes were identified through comprehensive bioinformatics analysis and named based on their physical locations on chromosomes. All the VrBBXs were divided into five groups based on their phylogenetic relationships, the number of B-box they contained and whether there was an additional CONSTANS, CO-like and TOC1 (CCT) domain. Homology and collinearity analysis indicated that the BBX genes in mung bean and other species had undergone a relatively conservative evolution. Gene duplication analysis showed that only chromosomal segmental duplication contributed to the expansion of VrBBX genes and that most of the duplicated gene pairs experienced purifying selection pressure during evolution. Gene structure and motif analysis revealed that VrBBX genes clustered in the same group shared similar structural characteristics. An analysis of cis-acting elements indicated that elements related to stress and hormone responses were prevalent in the promoters of most VrBBXs. The RNA-seq data analysis and qRT-PCR of nine VrBBX genes demonstrated that VrBBX genes may play a role in response to environmental stress. Moreover, VrBBX5, VrBBX10 and VrBBX12 are important candidate genes for plant stress response.

Conclusions
In this study, we systematically analyzed the genomic characteristics and expression patterns of the BBX gene family under ABA, PEG and NaCl treatments. The results will help us better understand the complexity of the BBX gene family and provide valuable information for future functional characteristics of specific genes in this family.
Chlamydia psittaci detected at a live poultry wholesale market in central China
Authors: Zhang Rusheng , Fu Huiyuan , Luo Can , Huang Zheng , Pei Ruiqing , Di Yu , Zhu Caiying , Peng Jiayi , Hu Huiqi , Chen Shan , Chen Jingfang , Chen Lamei , Xu Mingzhong , Yang Xuewen , Yang Rengui 
Published: June 2024

Abstract
Background
We investigated the presence of Chlamydia psittaci in poultry and the environment in live poultry wholesale markets in Changsha during 2021–2022 and conducted a phylogenetic analysis to understand its distribution in this market.

Methods
In total, 483 samples were analyzed using real-time polymerase chain reaction and 17 C. psittaci-positive samples using high-throughput sequencing, BLAST similarity, and phylogenetic analysis.

Results
Twenty-two out of 483 poultry and environmental samples were positive for C. psittaci (overall positivity rate: 4.55%) with no difference in positivity rates over 12 months. Chlamydia psittaci was detected at 11 sampling points (overall positivity rate: 27.5%), including chicken, duck, and pigeon/chicken/duck/goose shops, with pigeon shops having the highest positivity rate (46.67%). The highest positivity rates were found in sewage (12.5%), poultry fecal (7.43%), cage swab (6.59%), avian pharyngeal/cloacal swab (3.33%), and air (2.29%) samples. The ompA sequences were identified in two strains of C. psittaci, which were determined to bear genotype B using phylogenetic analysis. Thus, during monitoring, C. psittaci genotype B was detected in the poultry and environmental samples from the poultry wholesale market in Changsha.

Conclusions
To address the potential zoonotic threat, C. psittaci monitoring programs in live poultry markets should be enhanced.