bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histone chaperones, histone acetylation, and the fluidity of the chromogenome
Authors: Hansen Jeffrey C. , Nyborg Jennifer K. , Luger Karolin , Stargell Laurie A. 
Published: April 2010

AbstractThe “chromogenome” is defined as the structural and functional status of the genome at any given moment within a eukaryotic cell. This article focuses on recently uncovered relationships between histone chaperones, post‐translational acetylation of histones, and modulation of the chromogenome. We emphasize those chaperones that function in a replication‐independent manner, and for which three‐dimensional structural information has been obtained. The emerging links between histone acetylation and chaperone function in both yeast and higher metazoans are discussed, including the importance of nucleosome‐free regions. We close by posing many questions pertaining to how the coupled action of histone chaperones and acetylation influences chromogenome structure and function. J. Cell. Physiol. 224: 289–299, 2010. © 2010 Wiley‐Liss, Inc.
Regulation of adult bone turnover by sex steroids
Authors: Frenkel Baruch , Hong Albert , Baniwal Sanjeev K. , Coetzee Gerhard A. , Ohlsson Claes , Khalid Omar , Gabet Yankel 
Published: April 2010

AbstractRecent reports reveal increasing complexity of mechanisms underlying the bone sparing effects of sex steroids. This review focuses on mechanisms by which sex steroids attenuate endocortical and trabecular adult bone turnover, perhaps their most important property as bone mass regulators. Clearly, estrogen withdrawal increases osteoclast number and bone resorption; however, important open questions are the extent to which osteoblasts and their precursors are involved, and the relative contributions of the RANK/RANKL/OPG system, Fas ligand and Runx2. In addition to reviewing these aspects of estrogen action, we also discuss proskeletal effects of androgens on the adult male skeleton, including aromatization to estrogens and male‐specific mechanisms. Detailed understanding of skeletal site‐ and gender‐dependent mechanisms by which sex steroids protect the adult skeleton will provide the foundation for improved risk assessment, prevention and management of osteoporosis. J. Cell. Physiol. 224: 305–310, 2010. © 2010 Wiley‐Liss, Inc.
Shepherding AKT and androgen receptor by Ack1 tyrosine kinase
Authors: Mahajan Kiran , Mahajan Nupam P. 
Published: April 2010

AbstractAck1 (also known as ACK, TNK2, or activated Cdc42 kinase) is a structurally unique non‐receptor tyrosine kinase that is expressed in diverse cell types. It integrates signals from plethora of ligand‐activated receptor tyrosine kinases (RTKs), for example, MERTK, EGFR, HER2, PDGFR and insulin receptor to initiate intracellular signaling cascades. Ack1 transduces extracellular signals to cytosolic and nuclear effectors such as the protein kinase AKT/PKB and androgen receptor (AR), to promote cell survival and growth. While tyrosine phosphorylation of AR at Tyr267 regulates androgen‐independent recruitment of AR to the androgen‐responsive enhancers and transcription of AR target genes to drive prostate cancer progression, phosphorylation of an evolutionarily conserved Tyrosine 176 in the kinase domain of AKT is essential for mitotic progression and positively correlates with breast cancer progression. In contrast to AR and AKT, Ack1‐mediated phosphorylation of the tumor suppressor Wwox at Tyr287 lead to rapid Wwox polyubiquitination followed by degradation. Thus, by its ability to promote tumor growth by negatively regulating tumor suppressor such as Wwox and positively regulating pro‐survival factors such as AKT and AR, Ack1 is emerging as a critical player in cancer biology. In this review, we discuss recent advances in understanding the physiological functions of Ack1 signaling in normal cells and the consequences of its hyperactivation in various cancers. J. Cell. Physiol. 224: 327–333, 2010. © 2010 Wiley‐Liss, Inc.
Direct and progressive differentiation of human embryonic stem cells into the chondrogenic lineage
Authors: Gong Guochun , Ferrari Deborah , Dealy Caroline N. , Kosher Robert A. 
Published: April 2010

AbstractTreatment of common and debilitating degenerative cartilage diseases particularly osteoarthritis is a clinical challenge because of the limited capacity of the tissue for self‐repair. Because of their unlimited capacity for self‐renewal and ability to differentiate into multiple lineages, human embryonic stem cells (hESCs) are a potentially powerful tool for repair of cartilage defects. The primary objective of the present study was to develop culture systems and conditions that enable hESCs to directly and uniformly differentiate into the chondrogenic lineage without prior embryoid body (EB) formation, since the inherent cellular heterogeneity of EBs hinders obtaining homogeneous populations of chondrogenic cells that can be used for cartilage repair. To this end, we have subjected undifferentiated pluripotent hESCs to the high density micromass culture conditions we have extensively used to direct the differentiation of embryonic limb bud mesenchymal cells into chondrocytes. We report that micromass cultures of pluripotent hESCs undergo direct, rapid, progressive, and substantially uniform chondrogenic differentiation in the presence of BMP2 or a combination of BMP2 and TGF‐β1, signaling molecules that act in concert to regulate chondrogenesis in the developing limb. The gene expression profiles of hESC‐derived cultures harvested at various times during the progression of their differentiation has enabled us to identify cultures comprising cells in different phases of the chondrogenic lineage ranging from cultures just entering the lineage to well differentiated chondrocytes. Thus, we are poised to compare the abilities of hESC‐derived progenitors in different phases of the chondrogenic lineage for cartilage repair. J. Cell. Physiol. 224: 664–671, 2010. © 2010 Wiley‐Liss, Inc.
An empirical evaluation of three popular training programs to improve interpersonal skills
Authors: Kraiger Kurt , Kirkpatrick Stephen 
Published: April 2010

AbstractAs part of their talent development efforts, organizations implement training and development programs that often include some form of interpersonal or behavioral assessment. The study examined in this article compares three popular interpersonal skills training programs for measuring and understanding one's interpersonal style: Inscape's DiSC model, TRACOM Group's Social Style Model, and Consulting Psychologist Press's Myers‐Briggs Type Indicator. The facilitators found that participants in each program held positive reactions to training; participants in the Social Style training scored significantly higher than did participants in the DiSC and MBTI programs on a learning measure; and participants in the Social Style training scored significantly higher than did participants in the DiSC and MBTI programs on two measures of participants' skill at analyzing and responding to the interpersonal behaviors of others.
Should leaders cultivate love or fear?: Humanistic leadership versus the machiavellian prince
Authors: Kirkpatrick J. Stephen 
Published: April 2010

AbstractHeroic Leadership: Best Practices from a 450‐Year‐Old Company That Changed the WorldBy Chris LowneyChicago: Loyola Press, 2005. 330 pp. ISBN 978‐0829421156. $16.95.Reviewed by J. Stephen Kirkpatrick, Ph.D.
Trauma in organizations: Prevention and treatment with emergent strategies from alternative psychology
Authors: Hartung John , Nagireddy Chandra 
Published: April 2010

AbstractEffective organizations intend to select employees who are already emotionally healthy and can be resilient in the face of difficult challenges. There is also growing interest in helping employees learn to be even more resilient, on the principle that prevention is preferred to subsequent treatment. Plans are also made for treatment for situations where selection and prevention efforts prove inadequate and when employees become negatively affected by difficult events. This article describes innovative strategies that can be used for both prevention and treatment.
Posttraumatic stress disorder and the perceived consequences of seeking therapy among U.S. Army special forces operators exposed to combat
Authors: Espinoza Jessica M. 
Published: April 2010

AbstractThe goal of this study was to ascertain the level of PTSD symptoms experienced by Special Forces Operators (SFOs) who have been exposed to combat and compare these rates to the PTSD rates of the general U.S. population and general military population. A secondary goal was to discover whether SFOs were aware that therapy was available to them through the U.S. Army and, if so, whether they would seek this therapy for PTSD. The last goal was to discover whether SFOs who chose not to seek therapy while still serving did so because they feared negative consequences. Data were collected from 68 SFOs who had been exposed to combat. Results indicated that SFOs are experiencing symptoms of PTSD at a rate that is higher than that of the general U.S. population and somewhat lower than that of the general military population. Also, results indicated that a large percentage of the sample would not seek treatment for PTSD due to perceived negative consequences.
A kinetic study of the reactions of sulfate and dihydrogen phosphate radicals with epicatechin, epicatechingallate, and epigalocatechingallate
Authors: Villata Laura S. , Gonzalez Mónica C. , Mártire Daniel O. 
Published: April 2010

AbstractThe bimolecular rate constants for the reactions of sulfate radicals with epicatechin (EC), epicatechingallate (ECG), and epigallocatechingallate (EGCG) were found to be (1.46 ± 0.06) × 109, (1.20 ± 0.08) × 109, and (1.04 ± 0.07) × 109, respectively. The activation energy [EA = 9 ± 3 kJ mol−1] and preexponential factor [A = (4.8 ± 0.6) × 1010] for the reaction of EC with the sulfate radical were measured in the temperature range 288–303 K. The phenoxyl radicals of EC (λmax = 310 nm) were obtained both by the reaction of this flavonoid with the sulfate radicals and by photoionization. The measured bimolecular rate constants for the reactions of the dihydrogen phosphate radicals with EC, ECG, and EGCG were (7.8 ± 0.9) × 108, (8.5 ± 0.4) × 108, and (6.8 ± 0.4) × 108, respectively. © 2010 Wiley Periodicals, Inc. Int J Chem Kinet 42: 391–396, 2010
A 13‐year‐old girl with proximal weakness and hypertrophic cardiomyopathy with danon disease
Authors: Kim Hunmin , Cho Anna , Lim Byung Chan , Kim Min Jung , Kim Ki Joong , Nishino Ichizo , Hwang Yong Seung , Chae Jong‐Hee 
Published: April 2010

AbstractDanon disease is caused by deficiency of lysosome‐associated membrane protein‐2 (LAMP‐2). It is characterized clinically by cardiomyopathy, myopathy, and mental retardation in boys. Herein we report a 13‐year‐old female patient with Danon disease who presented with early‐onset skeletal myopathy and cardiomyopathy. She had a de novo novel mutation in the LAMP2 gene, and her muscles showed many autophagic vacuoles with sarcolemmal features and complete absence of LAMP‐2 expression. To the best of our knowledge, this girl is one of the earliest‐onset manifesting carriers of Danon disease with typical muscle pathology. Muscle Nerve, 2010
Localization of frequency‐dependent conduction block in carpal tunnel syndrome
Authors: Watson Bradley V. , Doherty Timothy J. 
Published: April 2010

AbstractFrequency‐dependent conduction block (FDB) has been demonstrated in subjects with carpal tunnel syndrome (CTS) when the median nerve was stimulated at 30‐HZ frequency proximal to the carpal tunnel (CT). However, it was still questionable whether FDB occurred within the region of the CT or more distally. High‐frequency nerve stimulation (HFNS) was performed in controls and in CTS subjects while stimulating the median nerve proximal and distal to the carpal tunnel. The degree of FDB was measured by comparing the 20th thenar CMAP with the 1st following a train of 20 stimuli at 30‐HZ. FDB occurred across the CT in 11/12 studies (91.7%) and across the distal portion of the palmar aponeurosis–distal terminal motor branches in 5 of the 11 studies (41.7%). These results suggest that the safety margin for impulse transmission can be impaired distal to the presumed site of injury in CTS. Muscle Nerve, 2010
Electrophysiological characteristics of motor units and muscle fibers in trained and untrained young male subjects
Authors: Duez Lene , Qerama Erisela , Fuglsang‐Frederiksen Anders , Bangsbo Jens , Jensen Troels S. 
Published: April 2010

AbstractWe hypothesized that the amplitudes of compound muscle action potentials (CMAPs) and interference pattern analysis (IPA) would be larger in trained subjects compared with untrained subjects, possibly due to hypertrophy of muscle fibers and/or increased central drive. Moreover, we hypothesized that the untrained muscle is less excitable compared with the trained muscle. An electromyographic (EMG) needle electrode was used to record the IPA at maximal voluntary effort. The CMAP was obtained by stimulating the musculocutaneous nerve and recording the brachial biceps muscle using surface electrodes. CMAPs were obtained by direct muscle stimulation (DMS) with two stainless‐steel subdermal electrodes placed subcutaneously in the distal third of the muscle. Amplitudes of CMAP and IPA were significantly larger in trained subjects compared with untrained subjects. We found no differences between trained and untrained subjects in IPA power spectrum and turns per second or amplitude of the CMAPs obtained by DMS. Muscle fiber hypertrophy and/or altered central drive may account for our results, but there was no indication of changes in muscle fiber excitability. Muscle Nerve, 2010
Localization of motor nerve branches of the human psoas muscle
Authors: Van Campenhout Anja , Hubens Guy , Fagard Katrien , Molenaers Guy 
Published: April 2010

AbstractEndplate‐targeted botulinum toxin injections can achieve optimal neuromuscular blockade. The goal of this study was to identify the motor endplate (MEP) zone in the human psoas muscle through dissection. In 24 human cadaver psoas muscles the nerve branches and their intramuscular course were followed by stereoscopic microscopic dissection as far as their terminal ramifications. From the lumbar plexus, an average of 3.7 (range 2–7) nerve branches enter the psoas muscle. The proximal and distal limit of the MEP‐zone are situated at about 30% and 70%, respectively, of the distance between the twelfth thoracic vertebra (Th12) and the passing of the psoas under the inguinal ligament. In reference to the sacral promontory (P), these limits are respectively from 50% of the Th12‐P distance to 20% of the P‐pubis distance. This study of the MEP zone of the human psoas muscle can allow the clinician to inject BTX‐A close to its site of action. Muscle Nerve, 2010
Fus gene mutations in familial and sporadic amyotrophic lateral sclerosis
Authors: Rademakers Rosa , Stewart Heather , Dejesus‐Hernandez Mariely , Krieger Charles , Graff‐Radford Neill , Fabros Marife , Briemberg Hannah , Cashman Neil , Eisen Andrew , Mackenzie Ian R.A. 
Published: April 2010

AbstractMutations in the fused in sarcoma (FUS) gene have recently been found to cause familial amyotrophic lateral sclerosis (FALS). We screened FUS in a cohort of 200 ALS patients [32 FALS and 168 sporadic ALS (SALS)]. In one FALS proband, we identified a mutation (p.R521C) that was also present in her affected daughter. Their clinical phenotype was remarkably similar and atypical of classic ALS, with symmetric proximal pelvic and pectoral weakness. Distal weakness and upper motor neuron features only developed late. Neuropathological examination demonstrated FUS‐immunoreactive neuronal and glial inclusions in the spinal cord and many extramotor regions, but no TDP‐43 pathology. We also identified a novel mutation (p.G187S) in one SALS patient. Overall, FUS mutations accounted for 3% of our non‐SOD1, non‐TARDBP FALS cases and 0.6% of SALS. This study demonstrates that the phenotype with FUS mutations extends beyond classical ALS cases. Our findings suggest there are specific clinicogenetic correlations and provide the first detailed neuropathological description. Muscle Nerve, 2010
Factors associated with persistence of cholinesterase inhibitor treatments in the elderly
Authors: Pariente Antoine , Pinet Marion , Moride Yola , Merlière Yvon , Moore Nicholas , Fourrier‐Réglat Annie 
Published: April 2010

AbstractPurposeTo identify factors associated with one‐year persistence of cholinesterase inhibitor (ChI) treatments.MethodsA retrospective cohort study was performed using the reimbursement database of the Echantillon Généraliste des Bénéficiaires, a 1/96e representative sample of subjects affiliated to the French National Healthcare Insurance System. Among this, patients who initiated a ChI treatment between 1 January 2004 and 31 December 2005 and for whom 1 year of follow‐up in the database after treatment initiation was available were identified. One‐year persistence of ChI treatment was defined as an ongoing treatment without dispensing interval exceeding 60 consecutive days during the 12 months following treatment initiation. Drug switches were not considered as treatment discontinuation. A multivariate logistic regression was conducted to identify, among patients characteristics (sociodemographic, drug uses), factors associated with one‐year persistence of ChI treatments.ResultsAmong the 942 patients who initiated a treatment with ChI during the study period, 72.4% were women; mean age was 79.6 years (SD = 7.4). Patients used eight other different drugs in median (Inter‐Quartile Range: 5–11); 63.7% used psychotropics, 63.6% used cardiovascular drugs. One‐year persistence of ChI treatments was estimated at 45.3%. Persistence of ChI treatments was lower in patients aged 80 years and over (OR = 0.74, 95%CI: 0.57–0.96); it was higher in patients using antidepressants at ChI treatment initiation (OR = 1.38, 95%CI: 1.05–1.82).ConclusionsOne‐year persistence of ChI treatment was estimated at 45.3% in this French sample. To optimize persistence of ChI treatment in the demented, patients poorly symptomatic and/or aged over 80 years should be especially monitored. Copyright © 2010 John Wiley & Sons, Ltd.
Analgesic use and the risk for progression of chronic kidney disease
Authors: Kuo Hsin‐Wei , Tsai Shang‐Shyue , Tiao Mao‐Meng , Liu Yi‐Chun , Lee I‐Ming , Yang Chun‐Yuh 
Published: April 2010

AbstractPurposeThe chronic effect of various analgesics on the progression of chronic kidney disease (CKD) is inconclusive. There is also lack of information on the renal safety of selective cyclooxygenase‐2 (COX‐2) inhibitors. This study aimed to clarify the renal risk of analgesic use in CKD patients.MethodsA cohort study using a nationally representative database randomly sampled from National Health Insurance (NHI) enrollees was performed. The study population included a total of 19,163 newly diagnosed CKD patients. Clinical conditions were defined by diagnostic codes and exposure information on analgesics was derived from service claims. Cox proportional hazard model was used to assess the association between analgesic use and the risk of progression to end stage renal disease (ESRD).ResultsCKD patients using acetaminophen, aspirin, and non‐selective non‐steroidal anti‐inflammatory drugs (NSAIDs) had an increased risk for ESRD with multivariable‐adjusted HRs (95%CIs) of 2.92 (2.47–3.45), 1.96 (1.62–2.36), and 1.56 (1.32–1.85), respectively. The trends toward higher risk with increasing exposure dose were significant for all classes of analgesics (all P for trend < 0.001). Among COX‐2 inhibitors, only rofecoxib, but not celecoxib, shows a significant risk association with ESRD (HR = 1.98; 95%CI, 1.15–3.40).ConclusionsOur data indicated exacerbating effects of acetaminophen, aspirin, and non‐selective NSAIDs on CKD in a dose‐dependent manner. For COX‐2 inhibitors, only rofecoxib showed an increased risk for ESRD. Although the possibility of residual confounding cannot be completely ruled out, given the common use of analgesics, the possible relation suggested by this study warrants further investigation. Copyright © 2010 John Wiley & Sons, Ltd.
Crisis resolution in older people's mental healthcare
Authors: Obinwa Thomas , Goel Tarun , Sule Akeem 
Published: April 2010

AbstractThe Crisis Resolution and Home Treatment (CRHT) team's role in acute mental healthcare services for working age adults is well established throughout England, but this is less so for older adults despite government policy and initiatives promoting equality of care. The authors highlight the need to extend this care model to older people's mental healthcare and suggest some possible ways of achieving this. Copyright © 2010 Wiley Interface Ltd
Isolation of Exophiala dermatitidis from pigmented sputum in a cystic fibrosis patient
Authors: Griffard Emily A. , Guajardo Jesus R. , Cooperstock Michael S. , Scoville Caryn L. 
Published: April 2010

AbstractA 16‐year‐old female with cystic fibrosis (CF) presented with an acute respiratory exacerbation during which black flecks were observed in the spontaneously expectorated sputum. The production of this pigmented sputum was subsequently attributed to Exophiala dermatitidis hyphae. Treatment with antibiotics, corticosteroids, and antifungal medications led to an initial resolution of symptoms and clearance of the black pigment from her sputum. However, the patient again presented nine months later with reappearance of the pigmented flecks and concomitant clinical deterioration and was subsequently treated with an extended course of voriconazole. To the authors' knowledge, this is the first case report of fungal colonization by E. dermatitidis presenting as black flecks spontaneously expectorated in CF sputum. Pediatr Pulmonol. 2010; 45:508–510. © 2010 Wiley‐Liss, Inc.
Pre‐treatment of titanium surfaces by fibronectin: in situ adsorption and effect of concentration
Authors: Payet V. , Dini T. , Brunner S. , Galtayries A. , Frateur I. , Marcus P. 
Published: April 2010

AbstractIn this work, kinetics data on adsorption of fibronectin (Fn) on passivated Ti surfaces (Ti quartz crystals) in phosphate buffered saline (PBS) solution were obtained from in situ investigations with electrochemical quartz crystal microbalance (EQCM): from experiments performed at 15 and 60 mg l−1 Fn solution concentrations, the maximum adsorption was reached within 30 min, and Fn adsorption seemed to be partially reversible, as about 15% of the initially adsorbed protein were removed upon PBS rinsing. The remaining amount of adsorbed Fn was around 1000 ng cm−2 and was similar for both protein concentrations in solution. Moreover, differences in kinetics were observed between the two concentrations: the initial adsorption rate was much larger at 60 mg l−1 than at 15 mg l−1. Ex situ X‐ray photoelectron spectroscopy (XPS) characterizations were used to examine the surface after adsorption under flow (EQCM measurements) or in static conditions: identification of the adsorbed protein and of the passivated TiO2 layer on metallic Ti. With bulk Ti samples, an isotherm of adsorption of Fn in PBS was established on the basis of a selection of Fn solution concentrations and on the maximum time required to get a steady state, for a given concentration. The equivalent thicknesses of adsorbed Fn (dFn (XPS), model of a continuous layer adsorbed on the passivated Ti samples) were estimated by XPS. At saturation, a plateau is reached corresponding to an equivalent thickness of 5.5 nm for Fn solution concentrations larger than 50 mg l−1. The dFn (XPS) values of the experiments performed under flow are in satisfactory agreement with the values determined from static adsorption experiments. Copyright © 2010 John Wiley & Sons, Ltd.