bluuebunny/crossref_metadata_2025_split huggingface dataset:
El canon de la periferia
Authors: Lemes Karina Beatriz , García Saraví Mercedes 
Published: December 2010

Intentaremos mostrar cómo venimos trabajando con la reconstrucción de la memoria literaria de la provincia de Misiones a partir de la recopilación de los manuscritos de sus autores más representativos. Hemos utilizado para nuestra lectura, en cruce con la crítica genética, las relaciones que Fernando Ainsa establece entre canon y periferia, espacios de la memoria y construcción de la utopía. Ainsa concibe la escritura como proceso genético que en su origen es personal, visceral y solitario, una búsqueda constante de identidad que se enriquece en contacto con el mundo, con la apertura de fronteras. Estas vinculaciones nos han permitido interpretar las prácticas sociales que fundaron actividades estéticas en la distancia de los centros de poder argentinos.
Aquí se vende todo
Authors: Ran Amalia 
Published: December 2010

Aunque « memoria » sea la palabra más usada en el contexto histórico reciente de Argentina, es el olvido aquello de lo que más se habla, y lo que domina al final el discurso público de las últimas décadas. ¿ Cuáles son las distintas formas de « recordar » el pasado doloroso en un entorno que intenta silenciarlo al transformar la memoria en un objeto-fetiche ? ¿ De qué modo conserva el espacio urbano —la ciudad y sus múltiples lugares abiertos y cerrados— una memoria de la desgracia y del horror ?, y ¿ cómo se refleja ese espacio urbano dentro del texto narrativo ? El presente trabajo estudia la problemática de la ciudad globalizada del post-trauma y la desmemoria mediante el análisis de la novela de Horacio Vázquez-Rial, La capital del olvido (2004). Asimismo, propone analizar los efectos de los procesos de privatización y globalización que barrieron a Buenos Aires durante los noventa para explorar las diversas expresiones públicas y privadas de una cultura de culpa y vergüenza que niega recordar su pasado.
Griselda Gambaro, la voix d’une mémoire au théâtre
Authors: Suréda-Cagliani Sylvie 
Published: December 2010

En Argentine, durant les années de répression, d’abord avec la dictature de Juan Carlos Onganía (1966) puis avec celle de Rafael Videla (1976), le théâtre est un espace qui sert d’exutoire. Il est aussi un moyen d’expression qui met en scène les mœurs et les comportements humains. Ce travail propose de montrer que le théâtre de Griselda Gambaro met à la fois l’accent sur les dangers de l’arbitraire exercé par un pouvoir tyrannique et sur le rôle de l’art théâtral comme représentation esthétique de la mémoire.
Conscience fragmentaire et traumatisme de la mémoire collective dans le roman nicaraguayen contemporain
Authors: Chen Sham Jorge 
Published: December 2010

Quand on analyse les 7 récits sur l’amour et la guerre (1986) de Rosario Aguilar et Le rêve de l’ange (1999) de Gloria Elena Espinoza de Tercero une question se pose : de quelle manière la portée de la révolution sandiniste se manifeste dans la structure romanesque et sur le plan des histoires personnelles, à travers une mémoire collective et traumatisée. Les deux romans possèdent une structure fragmentaire, comme si le chaos et les traumatismes de la conscience apparaissaient par le biais d’une temporalité discontinue et qui propose la simultanéité et la fragmentation dans une mosaïque collective. Pour ces raisons, les histoires racontées se développent sur un plan intimiste, comme si les personnages se trouvaient dans l’obligation de se renfermer dans leur conscience. Dans ce cadre, les solutions politiques grandiloquentes sont impossibles et les personnages se contentent de clore, de manière individuelle, leurs expériences. Le dégoût et la déception s’emparent des personnages qui, d’un point de vue post-moderne, voient les pièges de la révolution et des discours politiques dans un Nicaragua troublé à la fin du XXème siècle.
Metaliteratura e identidad : Roberto Bolaño
Authors: Veres Luis 
Published: December 2010

Uno de los rasgos más característicos de la postmodernidad ha sido la crisis de los grandes relatos. A partir de la decadencia del lenguaje, de la historia y en general de todas las disciplinas teóricas y de los discursos redentores, la credibilidad se ha trasladado a los medios de comunicación. Ya Ángel Rama o Jean Franco señalaron que su influencia es inmensa en la sociedad actual y es determinante en la estructura y contenido de las nuevas novelas. Surgen así discursos fragmentarios en donde lo auto-referencial resulta muy importante y en donde la anécdota de la historia, de la tradición adquiere una función lúdica y ejemplarizante en un mundo en donde prima el malestar y en donde las identidades parecen borradas. La metaliteratura se erige así en obras de Piglia, Pauls, Roncagliolo, Fresán en un medio de reflexión sobre la propia identidad. Este trabajo trata de reflexionar sobre estos aspectos en la obra de Roberto Bolaño.
Protein Kinase D Orchestrates the Activation of DRAK2 in Response to TCR-Induced Ca2+ Influx and Mitochondrial Reactive Oxygen Generation
Authors: Newton Ryan H. , Leverrier Sabrina , Srikanth Sonal , Gwack Yousang , Cahalan Michael D. , Walsh Craig M. 
Published: December 2010

Abstract
DRAK2 is a serine/threonine kinase highly enriched in lymphocytes that raises the threshold for T cell activation and maintains T cell survival following productive activation. T cells lacking DRAK2 are prone to activation under suboptimal conditions and exhibit enhanced calcium responses to AgR stimulation. Despite this, mice lacking DRAK2 are resistant to organ-specific autoimmune diseases due to defective autoreactive T cell survival. DRAK2 kinase activity is induced by AgR signaling, and in this study we show that the induction of DRAK2 activity requires Ca2+ influx through the Ca2+ release-activated Ca2+ channel formed from Orai1 subunits. Blockade of DRAK2 activity with the protein kinase D (PKD) inhibitor Gö6976 or expression of a kinase-dead PKD mutant prevented activation of DRAK2, whereas a constitutively active PKD mutant promoted DRAK2 function. Knockdown of PKD in T cells strongly blocked endogenous DRAK2 activation following TCR ligation, implicating PKD as an essential intermediate in the activation of DRAK2 by Ca2+ influx. Furthermore, we identify DRAK2 as a novel substrate of PKD, and demonstrate that DRAK2 and PKD physically interact under conditions that activate PKD. Mitochondrial generation of reactive oxygen intermediates was necessary and sufficient for DRAK2 activation in response to Ca2+ influx. Taken together, DRAK2 and PKD form a novel signaling module that controls calcium homeostasis following T cell activation.
Disruption of Leptin Receptor–STAT3 Signaling Enhances Leukotriene Production and Pulmonary Host Defense against Pneumococcal Pneumonia
Authors: Mancuso Peter , Peters-Golden Marc , Goel Deepti , Goldberg Jared , Brock Thomas G. , Greenwald-Yarnell Megan , Myers Martin G. 
Published: December 2010

Abstract
The adipocyte-derived hormone leptin regulates energy homeostasis and the innate immune response. We previously reported that leptin plays a protective role in bacterial pneumonia, but the mechanisms by which leptin regulates host defense remain poorly understood. Leptin binding to its receptor, LepRb, activates multiple intracellular signaling pathways, including ERK1/2, STAT5, and STAT3. In this study, we compared the responses of wild-type and s/s mice, which possess a mutant LepRb that prevents leptin-induced STAT3 activation, to determine the role of this signaling pathway in pneumococcal pneumonia. Compared with wild-type animals, s/s mice exhibited greater survival and enhanced pulmonary bacterial clearance after an intratracheal challenge with Streptococcus pneumoniae. We also observed enhanced phagocytosis and killing of S. pneumoniae in vitro in alveolar macrophages (AMs) obtained from s/s mice. Notably, the improved host defense and AM antibacterial effector functions in s/s mice were associated with increased cysteinyl-leukotriene production in vivo and in AMs in vitro. Augmentation of phagocytosis in AMs from s/s mice could be blocked using a pharmacologic cysteinyl-leukotriene receptor antagonist. Phosphorylation of ERK1/2 and cytosolic phospholipase A2 α, known to enhance the release of arachidonic acid for subsequent conversion to leukotrienes, was also increased in AMs from s/s mice stimulated with S. pneumoniae in vitro. These data indicate that ablation of LepRb-mediated STAT3 signaling and the associated augmentation of ERK1/2, cytosolic phospholipase A2 α, and cysteinyl-leukotriene synthesis confers resistance to s/s mice during pneumococcal pneumonia. These data provide novel insights into the intracellular signaling events by which leptin contributes to host defense against bacterial pneumonia.
TCR-Dependent and -Independent Activation Underlie Liver-Specific Regulation of NKT Cells
Authors: Subleski Jeff J. , Hall Veronica L. , Wolfe Thomas B. , Scarzello Anthony J. , Weiss Jonathan M. , Chan Tim , Hodge Deborah L. , Back Timothy C. , Ortaldo John R. , Wiltrout Robert H. 
Published: December 2010

Abstract
The fate of invariant NKT (iNKT) cells following activation remains controversial and unclear. We systemically examined how iNKT cells are regulated following TCR-dependent and -independent activation with α-galactosylceramide (αGC) or IL-18 plus IL-12, respectively. Our studies reveal activation by αGC or IL-18 plus IL-12 induced transient depletion of iNKT cells exclusively in the liver that was independent of caspase 3-mediated apoptosis. The loss of iNKT cells was followed by repopulation and expansion of phenotypically distinct cells via different mechanisms. Liver iNKT cell expansion following αGC, but not IL-18 plus IL-12, treatment required an intact spleen and IFN-γ. Additionally, IL-18 plus IL-12 induced a more prolonged expansion of liver iNKT cells compared with αGC. iNKT cells that repopulate the liver following αGC had higher levels of suppressive receptors PD-1 and Lag3, whereas those that repopulate the liver following IL-18 plus IL-12 had increased levels of TCR and ICOS. In contrast to acute treatment that caused a transient loss of iNKT cells, chronic αGC or IL-18 plus IL-12 treatment caused long-term systemic loss requiring an intact thymus for repopulation of the liver. This report reveals a previously undefined role for the liver in the depletion of activated iNKT cells. Additionally, TCR-dependent and -independent activation differentially regulate iNKT cell distribution and phenotype. These results provide new insights for understanding how iNKT cells are systemically regulated following activation.
IL-6 Trans-Signaling Modulates TLR4-Dependent Inflammatory Responses via STAT3
Authors: Greenhill Claire J. , Rose-John Stefan , Lissilaa Rami , Ferlin Walter , Ernst Matthias , Hertzog Paul J. , Mansell Ashley , Jenkins Brendan J. 
Published: December 2010

Abstract
Innate immune responses triggered by the prototypical inflammatory stimulus LPS are mediated by TLR4 and involve the coordinated production of a multitude of inflammatory mediators, especially IL-6, which signals via the shared IL-6 cytokine family receptor subunit gp130. However, the exact role of IL-6, which can elicit either proinflammatory or anti-inflammatory responses, in the pathogenesis of TLR4-driven inflammatory disorders, as well as the identity of signaling pathways activated by IL-6 in a proinflammatory state, remain unclear. To define the contribution of gp130 signaling events to TLR4-driven inflammatory responses, we combined genetic and therapeutic approaches based on a series of gp130F/F knock-in mutant mice displaying hyperactivated IL-6–dependent JAK/STAT signaling in an experimental model of LPS/TLR4-mediated septic shock. The gp130F/F mice were markedly hypersensitive to LPS, which was associated with the specific upregulated production of IL-6, but not TNF-α. In gp130F/F mice, either genetic ablation of IL-6, Ab-mediated inhibition of IL-6R signaling or therapeutic blockade of IL-6 trans-signaling completely protected mice from LPS hypersensitivity. Furthermore, genetic reduction of STAT3 activity in gp130F/F:Stat3+/− mice alleviated LPS hypersensitivity and reduced LPS-induced IL-6 production. Additional genetic approaches demonstrated that the TLR4/Mal pathway contributed to LPS hypersensitivity and increased IL-6 production in gp130F/F mice. Collectively, these data demonstrate for the first time, to our knowledge, that IL-6 trans-signaling via STAT3 is a critical modulator of LPS-driven proinflammatory responses through cross-talk regulation of the TLR4/Mal signaling pathway, and potentially implicate cross-talk between JAK/STAT and TLR pathways as a broader mechanism that regulates the severity of the host inflammatory response.
Multicomponent Cascade Reactions: A Novel and Expedient Approach to Functionalized Indoles by an Unprecedented Nucleophilic Addition‐Heterocyclization‐Oxidative Alkoxycarbonylation Sequence
Authors: Gabriele Bartolo , Veltri Lucia , Salerno Giuseppe , Mancuso Raffaella , Costa Mirco 
Published: December 2010

AbstractA novel multicomponent cascade process is reported, based on the sequential combination between an initial nucleophilic attack step to an imine moiety and a palladium‐catalyzed oxidative heterocyclization‐alkoxycarbonylation process. By this new process, five simple molecules [2‐alkynylaniline imines, alcohol (ROH), carbon monoxide (CO), alcohol (ROH), and oxygen (O2)] are sequentially activated, selectively leading to high value‐added functionalized indole derivatives in a single operation.
Organocatalytic Enantioselective Aziridination of α‐Substituted α,β‐Unsaturated Aldehydes: Asymmetric Synthesis of Terminal Aziridines
Authors: Deiana Luca , Zhao Gui‐Ling , Lin Shuangzheng , Dziedzic Pawel , Zhang Qiong , Leijonmarck Hans , Córdova Armando 
Published: December 2010

AbstractThe first example of a highly enantioselective organocatalytic aziridination of α‐substituted α,β‐unsaturated aldehydes is presented. The reaction is catalyzed by simple chiral amines and gives access to highly functional terminal azirdines containing an α‐tertiary amine stereocenter in high yields and enantiomeric ratios (95.5:4.5–98:2).
Nuclear transport impairment of amyotrophic lateral sclerosis‐linked mutations in FUS/TLS
Authors: Ito Daisuke , Seki Morinobu , Tsunoda Yoshiko , Uchiyama Hidemi , Suzuki Norihiro 
Published: December 2010

AbstractObjective:The fused in sarcoma/translated in liposarcoma (FUS/TLS) protein was recently identified as a cause of familial amyotrophic lateral sclerosis (ALS), as well as a major component of the inclusion bodies found in subtypes of frontotemporal lobar degeneration (FTLD). These diseases now are collectively known as the novel clinical spectrum, FUS proteinopathy. ALS‐linked mutations of FUS are clustered in the C‐terminal region; however, the molecular properties of mutant FUS remain unclear. To gain insight into the pathogenesis of FUS proteinopathy, we examined the biochemical and cellular characteristics of mutant FUS in expressing cells.Methods and Results:Expression of ALS‐linked FUS mutations resulted in their assembly into cytoplasmic stress granules (SGs), cellular structures that package mRNA and RNA‐binding proteins during cell stress. A deletion mutant series revealed that the C‐terminal region in FUS is critical for nuclear retention via Ran guanosine triphosphatase‐dependent transport machinery. A parallel study of subcellular distribution revealed that ALS‐linked mutants additively disturb the function of the C‐terminus for nuclear traffic, resulting in cytoplasmic accumulation and the formation of SGs.Interpretation:This study demonstrates that mutant FUS, which is missing the nuclear traffic activity of the C‐terminus, is dislocated to cytoplasm and assembled into SGs, indicating that disruption of translational regulation and metabolism of mRNA via inappropriate/excessive SGs may be crucial for FUS proteinopathies. Our findings provide new biological and pathological insights into the FUS protein that should help our understanding of the pathogenesis of ALS/FTLD. Ann Neurol 2010
Poly(ethylene‐co‐vinyl acetate)/calcium phosphate nanocomposites: Mechanical, gas permeability, and molecular transport properties
Authors: Thomas P. Selvin , Sreekumar P. A. , Aprem Abi Santhosh , Thomas Sabu 
Published: December 2010

AbstractPoly(ethylene‐co‐vinyl acetate) (EVA)‐based nanocomposites were prepared by melt mixing in an internal mixer with nanocalcium phosphate in different weight percentages. The nanocalcium phosphate with 10‐nm size was prepared by the polymer‐induced crystallization technique. The mechanical properties as well as the gas permeability tests were performed to analyze the effect of nanofiller incorporation in to the polymer. Molecular transport of different solvents such as water, benzene, and n‐heptane was undertaken at room temperature for EVA nanocomposites with 0, 3, and 5% filler loading. Among the three, water showed less uptake and benzene showed maximum uptake. Transport parameters such as diffusion coefficient, sorption coefficient, and permeation coefficient were calculated, and all of them showed a decrease with respect to the filler loading. First‐order kinetics model was applied to investigate the transport kinetics. Also, the sorption curves were compared to theoretical predictions and found to be in good agreement except for water. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Hyperbranched polycarboxylates and their nanocomposites with ZnO: Investigations on the humidity‐sensitive properties
Authors: Li Peng , Li Yang , Yang Mujie 
Published: December 2010

AbstractHyperbranched polycarboxylates (HBPC) with different alkali metal cations (Li+, Na+, and K+) were prepared and characterized by 1H‐NMR and thermal gravimetric analysis. Thin film humidity sensors based on HBPC and its composite with ZnO nanorods were fabricated. The morphologies of films of HBPC and the nanocomposite were investigated by atomic force microscopy, which revealed uniform distribution of ZnO nanorods in HBPC. The humidity‐sensitive characteristics of HBPC and the nanocomposite were investigated at room temperature. It was found that the type of cations significantly affected the humidity‐sensing behaviors of HBPC. In addition, the nanocomposite exhibited better humidity‐sensitive properties than HBPC alone. Its impedance decreased for about three orders of magnitude over the range 19–97% RH, showing high sensitivity. Moreover, the nanocomposite exhibited fast response (∼ 9 and 10 s for response and recovery time between 97% RH and 33% RH, respectively) and small hysteresis (∼ 1.4% RH). The improved humidity‐sensing behaviors of the nanocomposite over HPBC alone is explained by taking into account the hyperbranched structure of the polymer and the special interactions of the polymer and ZnO with water molecules. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Waterborne polyurethane dispersions obtained by the acetone process: A study of colloidal features
Authors: Sardon H. , Irusta L. , Fernández‐Berridi M. J. , Luna J. , Lansalot M. , Bourgeat‐Lami E. 
Published: December 2010

AbstractWaterborne polyurethane (PU) dispersions were prepared from isophorone diisocyanate (IPDI), 2‐bis(hydroxymethyl) propionic acid (DMPA), 1,4‐butane diol (BD), poly(propylene glycol) (PPG), and triethylamine (TEA) by means of phase inversion through the acetone process. Changes in DMPA content, initial PU content in acetone, phase‐inversion temperature, evaporation conditions, and solvent nature were found to have a great impact on dispersion properties. Using a DMPA concentration of 0.30 mmol/gpol, stable PU dispersions could only be obtained when the initial PU content in acetone was at least 60 wt %, and phase‐inversion temperature was lower than 30°C. However, when increasing the PU content to 75 wt %, stable dispersions were obtained using DMPA concentrations three times lower. Finally, viscosity curves during the water addition step as well as a phase diagram were determined to understand the particle formation mechanism. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Preparation and characterization of high‐molecular‐weight sericin by γ irradiation
Authors: Sung Nak‐Yun , Byun Eui‐Baek , Kwon Sun‐Kyu , Yoo Young‐Choon , Jung Pil‐Mun , Kim Jae‐Hun , Choi Jong‐Il , Kim Mee‐Ree , Lee Ju‐Woon 
Published: December 2010

AbstractWe conducted this study to examine the changes in the molecular structure and physiological activities of silk sericin after γ irradiation. Sericin from Bombyx
mori was extracted with an Na2CO3 solution. The molecular weight distribution of sericin increased in the gel permeation chromatography and sodium dodecyl sulfate/polyacrylamide gel electrophoresis results as the irradiation dose increased. Circular dichroism data also revealed that the α‐helix contents decreased with the irradiation dose. Ultraviolet absorption was shown a different pattern between the irradiated and unirradiated sericin. However, the Fourier transform infrared spectrum was not changed in all of the groups. Furthermore, the irradiated sericin was significantly increased in 2,2‐diphenyl‐1‐picryl‐hydrazil radical scavenging, and the tyrosinase inhibitory activities increased with irradiation dose. Therefore, γ irradiation was an effective method for producing high‐molecular‐weight sericin and for developing functional foods and cosmetics. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Simultaneous synthesis, stabilization, and self‐assembly of microscale drug particles in polymer films
Authors: Meng Xiangxin , Yang Dachuan , Mitra Somenath 
Published: December 2010

AbstractThe antisolvent synthesis of micrometer‐scale particles, their stabilization in suspension, and their subsequent self‐assembly as homogeneous polymer films suitable for drug delivery were studied. Ultrasonic agitation was used in the precipitation of the drug particulates, stabilization was carried out with hydroxypropyl methylcellulose (HPMC), and finally, drug‐encapsulated films containing HPMC and polyvinylpyrrolidone were synthesized. These contained as much 28% of the drug Griseofulvin, and the particles were distributed uniformly throughout the films. Most importantly, the redispersion of the drug‐loaded films in an aqueous matrix showed that the crystallinity remained unaltered, and there was no appreciable increase in the particle size distribution. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
The effects of intumescent flame retardant including ammonium polyphosphate/pentaerythritol and fly ash fillers on the physicomechanical properties of rigid polyurethane foams
Authors: Tarakcılar Ali Rıza 
Published: December 2010

AbstractIn this study, rigid polyurethane foams that contain up to 5.0 wt % fly ash (FA) being a by‐product of thermal power stations and being cheap source were successfully produced using a polyurethane injection machine. The effects of FA content on the thermal conductivity, compressive strength, and flammability were investigated. The morphology of the cell was observed under a special microscope. The incorporation of FA in rigid polyurethane foams may dramatically decrease production costs and reduce environmental pollution. In addition, the effects of intumescent flame retardant composed of ammonium polyphosphate and pentaerythritol were examined in pure rigid polyurethane foams and FA‐rigid polyurethane foams. It was found that 5.0 and 7.5 wt % intumescent flame retardant loadings enhanced the thermal stability and improved the flammability resistance of the foams. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011