bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anakinra as first‐line disease‐modifying therapy in systemic juvenile idiopathic arthritis: Report of forty‐six patients from an international multicenter series
Authors: Nigrovic Peter A. , Mannion Melissa , Prince Femke H. M. , Zeft Andrew , Rabinovich C. Egla , van Rossum Marion A. J. , Cortis Elisabetta , Pardeo Manuela , Miettunen Paivi M. , Janow Ginger , Birmingham James , Eggebeen Aaron , Janssen Erin , Shulman Andrew I. , Son Mary Beth , Hong Sandy , Jones Karla , Ilowite Norman T. , Cron Randy Q. , Higgins Gloria C. 
Published: November 2010

AbstractObjectiveTo examine the safety and efficacy of the interleukin‐1 (IL‐1) receptor antagonist anakinra as first‐line therapy for systemic juvenile idiopathic arthritis (JIA).MethodsPatients with systemic JIA receiving anakinra as part of initial disease‐modifying antirheumatic drug (DMARD) therapy were identified from 11 centers in 4 countries. Medical records were abstracted using a standardized instrument, and resulting data were analyzed to characterize concomitant therapies, clinical course, adverse events, and predictors of outcome.ResultsAmong 46 patients meeting inclusion criteria, anakinra monotherapy was used in 10 patients (22%), while 67% received corticosteroids and 33% received additional DMARDs. Outcomes were evaluated at a median followup interval of 14.5 months. Fever and rash resolved within 1 month in >95% of patients, while C‐reactive protein and ferritin normalized within this interval in >80% of patients. Active arthritis persisted at 1 month in 39% of patients, at 3 months in 27%, and at >6 months of followup in 11%. Approximately 60% of patients, including 8 of 10 receiving anakinra monotherapy, attained a complete response without escalation of therapy. Disease characteristics and treatment were similar in partial and complete responders, except that partial responders were markedly younger at onset (median age 5.2 years versus 10.2 years; P = 0.004). Associated adverse events included documented bacterial infection in 2 patients and hepatitis in 1 patient. Tachyphylaxis was not observed.ConclusionAnakinra as first‐line therapy for systemic JIA was associated with rapid resolution of systemic symptoms and prevention of refractory arthritis in almost 90% of patients during the interval examined. These results justify further study of IL‐1 inhibition as first‐line, rather than rescue, therapy in systemic JIA.
Bio‐electrospraying primary cardiac cells: In vitro tissue creation and functional study
Authors: Ng Keat‐Eng , Joly Pascal , Jayasinghe Suwan N. , Vernay Bertrand , Knight Richard , Barry Sean P. , McComick James , Latchman David , Stephanou Anastasis 
Published: November 2010

AbstractManifestations of myocardial infarctions have been recognized as one of the major killers in the Western world. Therefore, advancing and developing novel cardiac tissue repair and replacement therapeutics have great implications to our health sciences and well‐being. There are several approaches for forming cardiac tissues, non‐jet‐based and jet‐based methodologies. A unique advantage of jet‐based approaches is the possibility to handle living cells with a matrix for cell distribution and deposition in suspension, either as single or heterogeneous cell populations. Our previous studies on bio‐electrospraying of cardiac cells have shown great promise. Here, we show for the first time the ability to bio‐electrospray the three major cell types of the myocardium, both independently and simultaneously, for forming a fully functional cardiac tissue. Several samples are characterized in vitro and found to be indistinguishable in comparison to controls. Thus, we are describing a swiftly emerging novel biotechnique for direct cardiac tissue generation. Moreover, the present investigations pave the way for the development and optimization of a bio‐patterning approach for the fabrication of biologically viable cardiac tissue grafts for the potential treatment of severe heart failure after myocardial infarction.
Novel technique to reduce the size of a Fontan Diabolo stent fenestration
Authors: Anderson Ben , Bhole Vinay , Desai Tarak , Mehta Chetan , Stumper Oliver 
Published: November 2010

AbstractObjectives: To develop an effective catheter technique to reduce the size of a Diabolo stent fenestration in the failing Fontan circulation. Background: Diabolo stent fenestration is employed by many centers in the treatment of the failing Fontan patient. With subsequent recovery, exercise tolerance may be impaired by significant desaturation secondary to the right to left shunt across the fenestration. Complete fenestration closure carries the risk of recurrence of the initial symptoms and, hence, reduction of the size of fenestration should be the preferred technique. Methods: Twenty‐eight patients with failing Fontan circulations (16 early and 12 late) underwent Diabolo stent fenestration for relief of symptoms. Five of these patients remained very limited by severe desaturation even at rest, after complete recovery from symptoms. Further cardiac catheterization with crimping/reduction of the size of the waist of the stent was carried out using a technique whereby a snare catheter was placed over the waist of the stent aided by an arterio‐venous guidewire loop and a balloon catheter placed within the stent. Results: All 5 patients had successful stent reduction with improvement in saturations, whilst still maintaining a small residual fenestration. No complications were encountered. Conclusion: This novel technique of reduction of a diabolo stent fenestration, in a failing Fontan circulation, offers the advantages of avoidance of implanting further devices in the circulation and the ability to redilate the stent should symptoms recur. © 2010 Wiley‐Liss, Inc.
New Catalytic Materials for the Direct Epoxidation of Propylene by Molecular Oxygen
Authors: Seubsai Anusorn , Kahn Michael , Senkan Selim 
Published: November 2010

AbstractThe direct vapor‐phase production of propylene oxide (PO) from propylene and molecular oxygen without the use of a co‐reactant remains a challenging problem in industrial catalysis, in spite of several decades of research. Herein, the discovery of a new class of silica‐supported multimetallic RuO2–CuOx–NaCl catalysts for the direct synthesis of PO from propylene and molecular oxygen is reported. This trimetallic catalyst exhibits durability and delivers PO selectivities of 40–50 % at propylene conversions of 10–20 % within 240‐270 °C and at atmospheric pressure. The best performing catalysts are characterized by powder X‐ray diffraction (PXRD) and transmission electron microscopy (TEM) and are determined to be composed of nanocrystalline domains of the three phases of RuO2, CuOx, and NaCl.
Design, Synthesis and Characterisation of a Fluorescently Labelled CyPLOS Ionophore
Authors: Coppola Cinzia , Paciello Antonio , Mangiapia Gaetano , Licen Sabina , Boccalon Mariangela , De Napoli Lorenzo , Paduano Luigi , Tecilla Paolo , Montesarchio Daniela 
Published: November 2010

AbstractA novel fluorescently labelled synthetic ionophore, based on a cyclic phosphate‐linked disaccharide (CyPLOS) backbone and decorated with four tetraethylene glycol tails carrying dansyl units, has been synthesised in 12 steps in 26 % overall yield. The key intermediate in the synthetic strategy is a novel glucoside building block, serving through its 2‐ and 3‐hydroxy groups as the anchor point for flexible tetraethylene glycol tentacles with reactive azido moieties at their ends. To test the versatility of this glucoside scaffold, it was preliminarily functionalised with a set of diverse probes—as fluorescent, redox‐active or hydrophobic tags—either by reduction of the azides followed by condensation with activated carboxylic acid derivatives, or by a direct coupling with a terminal alkyne in a CuI‐promoted 1,3‐dipolar cycloaddition. Tagging of the monomeric building block with dansyl residues allowed us to prepare a fluorescent, amphiphilic macrocycle, which was investigated for its propensity to self‐aggregate in CDCl3—studied by means of concentration‐dependent 31P NMR spectroscopy experiments—and in aqueous solution, in which combined dynamic light scattering (DLS) and small‐angle neutron scattering (SANS) measurements provided a detailed physico‐chemical analysis of the self‐assembled systems, mainly organised in the form of large vesicles. Its ion‐transport properties through phospholipid bilayers, determined by HPTS fluorescence assays, showed this compound to be more active than the previously synthesised CyPLOS congeners. Solvent‐dependent fluorescence changes for the labelled ionophore in liposome suspension established that the dansyl moieties are dispersed in environments with polarity intermediate between those of CH2Cl2 and propan‐2‐ol, suggesting that the CyPLOS tentacles infiltrate the mid‐polar region of the membranes.
ChemInform Abstract: Synthesis of Amorphous Mg(BH4)2 from MgB2 and H2 at Room Temperature.
Authors: Fichtner Maximilian , et al. et al. 
Published: November 2010

AbstractUnsolvated amorphous Mg(BH4)2 is prepared by reactive ball milling of commercial MgB2 under 100 bar hydrogen pressure for up to 100 h with a yield of about 50%.
ChemInform Abstract: Novel RZn2Ga2 (R: La, Ce, Pr, Nd, Sm) Intermetallic Compounds with BaAl4‐Type Structure.
Authors: Verbovytskyy Yu. , Kaczorowski D. , Goncalves A. P. 
Published: November 2010

AbstractThe new title compounds are synthesized by arc melting of the elements (900—950 °C, 1 h) followed by annealing at 400 °C (20 d).
ChemInform Abstract: Synthesis and Characterization of KCu3S2 Microstructures Through a Composite‐Hydroxide Mediated Method.
Authors: Huang Linyong , Liu Jing , Zuo Zhiyuan , Liu Hong , Liu Duo , Wang Jiyang , Boughton Robert I. 
Published: November 2010

AbstractKCu3S2 is synthesized in the absence of any organic surfactant from a 3:2 mixture of elemental sulfur and CuCl2 in a 51.5:48.5 mixture of NaOH and KOH.
ChemInform Abstract: Pt(II)‐Catalyzed Cyclization of Alkyne‐Aldehydes.
Authors: Hong Jong Tai , Kang Min‐Jung , Jang Hye‐Young 
Published: November 2010

AbstractAn environmentally‐friendly cyclization of a series of alkyne‐aldehydes under Pt‐catalyzed hydrogenative conditions is presented.
ChemInform Abstract: Development of Safe and Scalable Continuous‐Flow Methods for Palladium‐Catalyzed Aerobic Oxidation Reactions.
Authors: Ye Xuan , Johnson Martin D. , Diao Tianning , Yates Matthew H. , Stahl Shannon S. 
Published: November 2010

AbstractThe Pd‐catalyzed aerobic alcohol oxidations developed on a small scale are translated into a scalable flow‐based process.
ChemInform Abstract: Unified Oxidation Protocol for the Synthesis of Carbonyl Compounds Using a Manganese Catalyst.
Authors: Kamijo Shin , Amaoka Yuuki , Inoue Masayuki 
Published: November 2010

AbstractThe use of MnCl2/BTP and MCPBA or KHSO5 offers an efficient and selective protocol for the oxidation of a variety of ethers, benzylic compounds and alcohols.
ChemInform Abstract: Iron Oxide Nanoparticles Grown on Carboxy‐Functionalized Graphite: An Efficient Reusable Catalyst for Alkylation of Arenes.
Authors: Rajpara Vikul , Banerjee Subhash , Sereda Grigoriy 
Published: November 2010

AbstractA novel heterogeneous hydrid catalyst is developed and applied for the Friedel—Crafts‐type alkylation of arenes.
ChemInform Abstract: Highly Active and Selective Supported Iron Oxide Nanoparticles in Microwave‐Assisted N‐Alkylations of Amines with Alcohols.
Authors: Gonzalez‐Arellano Camino , Yoshida Kenta , Luque Rafael , Gai Pratibha L. 
Published: November 2010

AbstractFe oxide nanoparticles stabilized on mesoporous silica are the most efficient catalyst for the selective N‐alkylation of amines with benzyl alcohols.
ChemInform Abstract: Triton B‐Mediated Efficient and Convenient Alkoxylation of Activated Aryl and Heteroaryl Halides.
Authors: Meshram H. M. , Goud P. Ramesh , Reddy B. Chennakesava , Kumar D. Aravind 
Published: November 2010

AbstractA simple and convenient one‐pot synthesis of aryl alkyl ethers by the alkoxylation of aryl halides in the presence of Triton B as nonmetallic base is described.
ChemInform Abstract: Synthesis and Properties of Brominated 6,6′‐Dimethyl‐ [2,2′‐bi‐1H‐indene]‐3,3′‐diethyl‐3,3′‐dihydroxy‐1,1′‐diones.
Authors: Chen Yong , Pang Meili , Cheng Kaige , Wang Ying , Han Jie , Meng Jiben 
Published: November 2010

AbstractThe bromination of substrate (I) is studied and the spectral, photochromic, and photomagnetic properties of the different products are investigated.
ChemInform Abstract: The Sandmeyer Reaction on Some Selected Heterocyclic Ring Systems: Synthesis of Useful 2‐Chloroheterocyclic‐3‐carbonitrile Intermediates.
Authors: da Silva Daniel , Samadi Abdelouahid , Chioua Mourad , Carreiras Maria do Carmo , Marco‐Contelles Jose 
Published: November 2010

AbstractThe method is successful for various substrate types, although the yields are only moderate to low.
ChemInform Abstract: Selective Base‐Promoted Synthesis of Dihydroisobenzofurans by Domino Addition/Annulation Reactions of ortho‐Alkynylbenzaldehydes.
Authors: Dell'Acqua Monica , Facoetti Diego , Abbiati Giorgio , Rossi Elisabetta 
Published: November 2010

AbstractThe sequential transformation of ortho‐alkynylbenzaldehydes in the presence of methanol proceeds generally with high regio‐ and stereoselectivity to provide the target compounds with (Z)‐configuration at the exocyclic double bond.
ChemInform Abstract: Convenient Synthesis of 2‐Aminothiophene Derivatives by Acceleration of Gewald Reaction under Ultrasonic Aqueous Conditions.
Authors: Mojtahedi Mohammad M. , Abaee M. Saeed , Mahmoodi Peyman , Adib Mehdi 
Published: November 2010

AbstractAn ultrasound‐promoted Gewald reaction is presented.
ChemInform Abstract: Hydroamination of 2‐Ethynyl‐4,5,6,7‐tetrahydroindoles: Toward 2‐Substituted Amino Derivatives of Indole.
Authors: Sobenina Lyubov' N. , Tomilin Denis N. , Petrova Ol'ga V. , Ushakov Igor' A. , Mikhaleva Al'bina I. , Trofimov Boris A. 
Published: November 2010

AbstractHydroamination of propynones (I) with dimethylamine gives the target amino derivatives (III) and (IV), whereas propynoates (V) yield only the corresponding amides (VI).
ChemInform Abstract: Synthesis of 1,2‐Disubstituted Benzimidazoles, 2‐Substituted Benzimidazoles and 2‐Substituted Benzothiazoles in SDS Micelles.
Authors: Bahrami Kiumars , Khodaei Mohammad M. , Nejati Akbar 
Published: November 2010

AbstractAdvantages of the title method are operational simplicity, high chemoselectivity, cheap and environmentally benign conditions.
ChemInform Abstract: Azide/Alkyne Resins for Quick Preparation of 1,4‐Disubstituted 1,2,3‐Triazoles.
Authors: Sirion Uthaiwan , Lee Jae Hak , Bae Yu Jin , Kim Hee Jun , Lee Byoung Se , Chi Dae Yoon 
Published: November 2010

AbstractA general procedure for the high throughput synthesis of 1,4‐disubstituted 1,2,3‐triazoles under optimized reaction conditions without conventional purification is developed.
ChemInform Abstract: Broensted Acid—Thiourea Co‐Catalysis: Asymmetric Synthesis of Functionalized 1,4‐Dihydropyridines from β‐Enamino Esters and α,β‐Unsaturated Aldehydes.
Authors: Yoshida Kohzo , Inokuma Tsubasa , Takasu Kiyosei , Takemoto Yoshiji 
Published: November 2010

AbstractThe optimized conditions lead to formation of 5,6‐unsubstituted dihydropyridines as pharmaceutical substructures with only moderate e.e.′s up to 80%.
ChemInform Abstract: Pseudo Four‐Component Synthesis of Benzopyranopyrimidines.
Authors: Ghahremanzadeh Ramin , Amanpour Tayebeh , Bazgir Ayoob 
Published: November 2010

AbstractA simple procedure is presented for the reaction of salicylic aldehydes, amines and malononitrile to give novel derivatives of the pharmaceutically interesting heterocyclic skeleton.
ChemInform Abstract: A Facile Synthesis of Novel Unsymmetrical N‐(4‐Oxo‐2‐phenyl‐3(4H)‐quinazolinoyl)‐N‐(aryl)acetamidines.
Authors: Khan Rasool , Arfan Mohammad , Mahmood Javeed , Anjum Shazia , Choudhary M. Iqbal 
Published: November 2010

AbstractEthanimidoate derivatives (I) react with electron‐rich aromatic amines to give the target compounds which are isolated as their HCl salts.
ChemInform Abstract: Thietanyl Protection in the Synthesis of 1‐Alkyl‐8‐bromo‐3‐methyl‐3,7‐dihydro‐1H‐purine‐2,6‐diones.
Authors: Khaliullin F. A. , Shabalina Yu. V. , Sharafutdinov R. M. 
Published: November 2010

AbstractA strategy for the selective N‐alkylation in 1‐position of purine derivative (I) is presented.
ChemInform Abstract: Zirconium‐Catalyzed Nagata Reaction for the Synthesis of 2‐Aryl‐1,3,2‐aryldioxaborins via a Mild Three‐Component Condensation of Phenols, Aldehydes, and Boronic Acid.
Authors: Zheng Hongchao , Hall Dennis G. 
Published: November 2010

AbstractA mild approach is developed with an electron‐deficient boronic acid (I) as coupling component.
ChemInform Abstract: Microwave Assisted One‐Pot Synthesis of Novel α‐Aminophosphonates and Their Biological Activity.
Authors: Rao Alahari Janardhan , Rao Pasupuleti Visweswara , Rao Valsani Koteswara , Mohan Challamchalla , Raju Chamarthi Naga , Reddy Cirandur Suresh 
Published: November 2010

AbstractVarious new α‐aminophosphonates (IV) are efficiently synthesized by a simple reaction of substituted aromatic/heterocyclic aldehydes (II), benzothiazole (I) and phosphites (III) under microwave irradiation without any catalyst.
ChemInform Abstract: Synthesis of 2‐Diphenylphosphinoyl‐3,5‐diaryl‐3,4‐dihydro‐2H‐telluropyrans by Reaction of Chalcones with Bis[(Diphenylphosphinoyl)methyl]telluride.
Authors: Silveira Claudio C. , Rinaldi Francieli , Bassaco Mariana M. , Kaufman Teodoro S. 
Published: November 2010

AbstractThe mild conditions allow a highly stereoselective access to the polysubstituted target compounds.
ChemInform Abstract: Total Synthesis of (‐)‐8‐Deoxyserratinine (IX) via an Efficient Helquist Annulation and Double N‐Alkylation Reaction.
Authors: Yang Yu‐Rong , Lai Zeng‐Wei , Shen Liang , Huang Jiu‐Zhong , Wu Xing‐De , Yin Jun‐Lin , Wei Kun 
Published: November 2010

AbstractThe strategy is general and can be applied to the preparation of many complex members of the Lycopodium family.
ChemInform Abstract: A Rapid Access to (.+‐.)‐Sedamine and Some Original N‐Benzyl Unsaturated Analogues.
Authors: Boussonniere Anne , Ranaivondrambola Tsiresy , Lebreton Jacques , Mathe‐Allainmat Monique 
Published: November 2010

AbstractQuarternization of the pyridine derivative (I) followed by hydride reduction and catalytic hydrogenation offers a short synthesis of racemic sedamine (VI) and norsedamine (XI).
ChemInform Abstract: Bioactive Microbial Metabolites. Part 36. Alchivemycin A, a Bioactive Polycyclic Polyketide with an Unprecedented Skeleton from Streptomyces sp.
Authors: Igarashi Yasuhiro , Kim Youngju , In Yasuko , Ishida Toshimasa , Kan Yukiko , Fujita Tsuyoshi , Iwashita Takashi , Tabata Hirokazu , Onaka Hiroyasu , Furumai Tamotsu 
Published: November 2010

AbstractThe title compound exhibits potential antimicrobial effects against Micrococcus luteus and shows inhibitory effects on tumor cell invasion.
ChemInform Abstract: Synthesis and Antibacterial Activity of Novel 4′′‐Carbamates of 6,11‐Di‐O‐methylerythromycin A.
Authors: Hu Xianming , et al. et al. 
Published: November 2010

AbstractTwenty‐four new 4′′‐carbamates (I) are synthesized and evaluated for their activity against erythromycin, methicillin and ampicillin susceptible and resistant bacteria.
ChemInform Abstract: Heterocycles in Organic Synthesis: Thiazoles and Triazoles as Exemplar Cases of Synthetic Auxiliaries
Authors: Dondoni Alessandro 
Published: November 2010

AbstractReview: key role of thiazole in the syntheses of carbohydrate‐based bioactive molecules; use of 1,2,3‐triazole as robust linker of complex molecules such as glycosyl amino acids, non‐natural nucleotides, 1,6‐oligomannosides and sialoside clusters on calixarene platform; <100 refs.
ChemInform Abstract: Synthetic Strategies in the Construction of Chromones
Authors: Li Nian‐Guang , Shi Zhi‐Hao , Tang Yu‐Ping , Ma Hong‐Yue , Yang Jian‐Ping , Li Bao‐Quan , Wang Zhen‐Jinag , Song Shu‐Lin , Duan Jin‐Ao 
Published: November 2010

AbstractReview: 112 refs.
Efficient mapping and acceleration of AES on custom multi‐core architectures
Authors: Pande Amit , Zambreno Joseph 
Published: November 2010

AbstractMulti‐core processors can deliver significant performance benefits for multi‐threaded software by adding processing power with minimal latency, given the proximity of the processors. Cryptographic applications are inherently complex and involve large computations. Most cryptographic operations can be translated into logical operations, shift operations, and table look‐ups. In this paper we design a novel processor (called mu‐core) with a reconfigurable Arithmetic Logic Unit, and design custom two‐dimensional multi‐core architectures on top of it to accelerate cryptographic kernels. We propose an efficient mapping of instructions from the multi‐core grid to the individual processor cores and illustrate the performance of AES‐128E algorithm over custom‐sized grids. The model was developed using Simulink and the performance analysis suggests a positive trend towards development of large multi‐core (or multi‐ µ‐core) architectures to achieve high throughputs in cryptographic operations. Copyright © 2010 John Wiley & Sons, Ltd.
Constrained range search query processing on road networks
Authors: Xuan Kefeng , Zhao Geng , Taniar David , Safar Maytham , Srinivasan Bala 
Published: November 2010

AbstractRange search is one of the most common queries in the spatial databases and geographic information systems (GIS). Most range search processing depends on the length of the distance that expresses the relative position of the objects of interest in the Euclidean space or road networks. But, in reality, the expected result is normally constrained by other factors (e.g. number of spatial objects, pre‐defined area, and so forth.) rather than the distance alone; hence, range search should be comprehensively discussed in various scenarios. In this paper, we propose two constrained range search approaches based on network Voronoi diagram, namely Region Constrained Range (RCR) and k nearest neighbor Constrained Range (kCR), which make the range search query processing more flexible to satisfy different requirements in a complex environment. The performance of these approaches is analyzed and evaluated to illustrate that both of them can process constrained range search queries very efficiently. Copyright © 2010 John Wiley & Sons, Ltd.
Extending the concurrency model of the real‐time specification for Java
Authors: Basanta‐Val P. , García‐Valls M. , Estévez‐Ayres I. 
Published: November 2010

AbstractThe current RTSJ (Real‐Time Specification for Java) threading model is dualized: a programmer has to decide between the high predictability offered by the region‐based model and the flexibility offered by the garbage collection. So far, there is no unique type of thread which offers both the high predictability of a non‐heap thread and the flexibility of a real‐time thread in a single entity. Furthermore, this lack has a serious impact on the programmer who has to deal with new and sometimes non‐trivial to use mechanisms, such as specific queues of objects or new types of threads, in order to avoid the priority inversion caused by the garbage collector. In order to tackle the concern properly and provide an improved and more generalized programming model, the authors propose a simple extension to the current threading model namedRealtimeThread++, in an attempt to introduce more flexibility in the RTSJ concurrency model. The paper describes the extension from several points of view: (i) the programmer, identifying scenarios that may benefit from it significantly; (ii) the real‐time Java technology perspective, identifying changes required in the current real‐time virtual machine to support it; and (iii) the accumulated experience, relating empirical results obtained from a software prototype that supports the extension. Copyright © 2010 John Wiley & Sons, Ltd.