bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biochemical comparison of osteoarthritic knees with and without effusion
Authors: Cattano Nicole M , Driban Jeffrey B , Balasubramanian Easwaran , Barbe Mary F , Amin Mamta , Sitler Michael R 
Published: November 2011

Abstract

Background
Several symptom-relieving interventions have been shown to be efficacious among osteoarthritis (OA) patients with knee effusion; however, not every symptomatic knee OA patient has clinical effusion. Results may be over-generalized since it is unclear if effused knees represent a unique pathological condition or subset compared to knees without effusion. The primary purpose of this study was to determine if biochemical differences existed between OA knees with and without effusion.

Methods
The present cross-sectional study consisted of 22 volunteers (11 with knee effusion, 11 without knee effusion) with confirmed late-stage radiographic knee OA (Kellgren-Lawrence score ≥ 3). Synovial fluid samples were collected and analyzed using a custom multiplex enzyme-linked immunosorbent assay to determine eight specific biomarker concentrations (e.g., catabolic, anabolic).

Results
Matrix metalloproteinase (MMP)-3, tissue inhibitor of MMPs (TIMP)-1, TIMP-2, and interleukin-10 were significantly higher in the knees with effusion than in the knees without effusion.

Conclusions
The biochemical differences that existed between knees with and without effusion provide support that OA subsets may exist, characterized by distinct biochemical characteristics and clinical findings (e.g., effusion).
Metachronous pulmonary and adrenal metastases after liver transplantation for hepatocarcinoma
Authors: Chen Shan-Wen , Wang Shuo , Wang Bo , Li Wei-Dong , Yan Sheng , Xie Li-Ping 
Published: November 2011

Abstract

Background
The worldwide experience of surgical resection for isolated metastasis following liver transplantation (LT) for hepatocellular carcinoma (HCC) is limited.

Methods
The case of a 60-year-old patient performed successful surgical management for metachronous pulmonary and adrenal metastases from HCC after LT.

Results
Eighty months after LT, he was presently alive and disease-free with a normal AFP value.

Conclusion
The case is an interesting report on a somehow indolent metastatic spread of HCC after LT. It should be considered that metachronous metastatic resectable disease, with no data of recurrence at the primary site in an operable patient, is an indication to perform a surgical resection.
Remarks on uniform attractors for the 3D non-autonomous Navier-Stokes-Voight equations
Authors: Dou Yiwen , Yang Xinguang , Qin Yuming 
Published: November 2011

Abstract
In this paper, we show the existence of pullback attractors for the non-autonomous Navier-Stokes-Voight equations by using contractive functions, which is more simple than the weak continuous method to establish the uniformly asymptotical compactness in H
1 and H
2.

2010 Mathematics Subject Classification: 35D05; 35M10
Risk factors for invasive fungal disease in critically ill adult patients: a systematic review
Authors: Muskett Hannah , Shahin Jason , Eyres Gavin , Harvey Sheila , Rowan Kathy , Harrison David 
Published: November 2011

Abstract
Introduction
Over 5,000 cases of invasive Candida species infections occur in the United Kingdom each year, and around 40% of these cases occur in critical care units. Invasive fungal disease (IFD) in critically ill patients is associated with increased morbidity and mortality at a cost to both the individual and the National Health Service. In this paper, we report the results of a systematic review performed to identify and summarise the important risk factors derived from published multivariable analyses, risk prediction models and clinical decision rules for IFD in critically ill adult patients to inform the primary data collection for the Fungal Infection Risk Evaluation Study.

Methods
An internet search was performed to identify articles which investigated risk factors, risk prediction models or clinical decisions rules for IFD in critically ill adult patients. Eligible articles were identified in a staged process and were assessed by two investigators independently. The methodological quality of the reporting of the eligible articles was assessed using a set of questions addressing both general and statistical methodologies.

Results
Thirteen articles met the inclusion criteria, of which eight articles examined risk factors, four developed a risk prediction model or clinical decision rule and one evaluated a clinical decision rule. Studies varied in terms of objectives, risk factors, definitions and outcomes. The following risk factors were found in multiple studies to be significantly associated with IFD: surgery, total parenteral nutrition, fungal colonisation, renal replacement therapy, infection and/or sepsis, mechanical ventilation, diabetes, and Acute Physiology and Chronic Health Evaluation II (APACHE II) or APACHE III score. Several other risk factors were also found to be statistically significant in single studies only. Risk factor selection process and modelling strategy also varied across studies, and sample sizes were inadequate for obtaining reliable estimates.

Conclusions
This review shows a number of risk factors to be significantly associated with the development of IFD in critically ill adults. Methodological limitations were identified in the design and conduct of studies in this area, and caution should be used in their interpretation.
Loss of Human Epidermal Growth Factor Receptor 2 (HER2) Expression in Metastatic Sites of HER2-Overexpressing Primary Breast Tumors
Authors: Niikura Naoki , Liu Jun , Hayashi Naoki , Mittendorf Elizabeth A. , Gong Yun , Palla Shana L. , Tokuda Yutaka , Gonzalez-Angulo Ana M. , Hortobagyi Gabriel N. , Ueno Naoto T. 
Published: November 2011

Purpose We evaluated whether patients with human epidermal growth factor receptor 2 (HER2) –positive primary breast tumors had metastatic tumors that were HER2 positive (concordant) or HER2 negative (discordant). We then evaluated whether treatment with trastuzumab or chemotherapy before biopsy of the metastasis had any effect on the rate of HER2 discordance. We also compared the overall survival durations of patients with HER2-concordant and -discordant tumors. Patients and Methods We retrospectively identified all patients who initially had been diagnosed with HER2-positive (immunohistochemistry 3+ and/or fluorescent in situ hybridization positive) primary breast cancer between 1997 and 2008 at MD Anderson Cancer Center who also had metastatic tumor biopsy results available for review. Results We included 182 patients who met our criteria. Forty-three (24%) of the 182 patients with HER2-positive primary tumors had HER2-negative metastatic tumors. The HER2 discordance rates differed significantly on the basis of whether patients received chemotherapy (P = .022) but not on the basis of whether patients received trastuzumab (P = .296). Patients with discordant HER2 status had shorter overall survival than did patients with concordant HER2 status (hazard ratio [HR], 0.43; P = .003). A survival difference remained among the 67 patients who received trastuzumab (HR, 0.56; P = .083) and 101 patients who did not (HR, 0.53; P = .033) before their metastasis biopsies. Conclusion We confirmed that loss of HER2-positive status in metastatic tumors can occur in patients with primary HER2-positive breast cancer. Our data strongly support the need for biopsies of metastatic lesions to accurately determine patient prognosis and appropriate use of targeted therapy.
Modeling Contextual Influences on Parents With Intellectual Disability and Their Children
Authors: Wade Catherine , Llewellyn Gwynnyth , Matthews Jan 
Published: November 2011

AbstractMany parents with intellectual disability experience living conditions associated with risk for children and parents. This study used structural equation modeling to test a theoretical model of the relationships among parent, child, family, and contextual variables in 120 Australian families where a parent had an intellectual disability. Findings revealed that parenting practices had a direct effect on children's well being, that social support was associated with children's well being through the mediator of parenting practices, and that access to social support had a direct influence on parenting practices. Implications of the findings for research, intervention, and policy are explored, with the goal of promoting optimal well being for children who are raised by parents with intellectual disability.
Community analysis of preservative-treated southern pine (Pinus spp.) using terminal restriction fragment length polymorphism (T-RFLP) analysis. Part 1: Fungal field study
Authors: Kirker Grant T. , Prewitt M. Lynn , Schultz Tor P. , Diehl Susan V. 
Published: November 2011

AbstractThe effects of chlorothalonil (CTN), butylated hydroxytoluene (BHT), and ammoniacal copper quat (ACQ-C) on the fungal community on southern yellow pine (SYP) were assessed using terminal restriction fragment length polymorphism (T-RFLP) analysis over 15 months. Field stakes, treated with 0.25 and 0.37% ACQ-C, 0.1 and 0.25% CTN, 2% BHT alone, 0.1 and 0.25% CTN combined with 2% BHT, and untreated controls, were installed in two field sites in Mississippi. Stakes were sampled at 90-day intervals and rated for decay damage. Fungal DNA was extracted and amplified by non-specific (total fungi) and specific (Basidiomycete) primers and processes for T-RFLP. a-Diversity (richness and diversity) and b-diversity (similarity between communities) were calculated by means of T-RFLP data. The presence of wood preservatives slowed the initial colonization of field stakes by total fungi, resulting in lower richness and diversity that increased over time; however, preservatives increased the richness and diversity of Basidiomycetes. The b-diversity of treated samples was less similar in the early stages of exposure (3–9 months), but coalesced over time into equilibrium communities that were similar to communities on untreated controls. Basidiomycete species compositions were different among treated samples while control communities shared more than 75% of their species. Correlations were found between depletion of 0.1% CTN and increasing fungal diversity, but no other significant correlations were found.
Sexual violence and associated factors among women in HIV discordant and concordant relationships in Uganda
Authors: Shuaib Faisal M.B. , Ehiri John E. , Jolly Pauline , Zhang Qionghui , Emusu Donath , Ngu Julius , Foushee Herman , Katongole Drake , Kirby Russell , Wabwire-Mangen Fred 
Published: November 2011

Abstract
HIV serodiscordance is a sexual partnership in which one partner is infected with HIV while the other is not. Managing emotional and sexual intimacy in HIV serodiscordant unions can be difficult due to concerns about HIV transmission and the challenge of initiating and maintaining safe sex. In situations where couples are jointly aware of their HIV status, women in serodiscordant unions may face increased risk of partner violence. We conducted an investigation to assess risk factors for HIV serodiscordance and determine if HIV serodiscordance is associated with incident sexual violence among a cohort of women attending HIV post-test club services at three AIDS Information Centers (AICs) in Uganda. Using a prospective study of 250 women, we elicited information about sexual violence using structured face-to-face interviews. Sexual violence and risk factors were assessed and compared among HIV positive women in HIV discordant unions, HIV negative women in discordant unions, and HIV negative women in negative concordant unions. Multivariable logistic regression was used to assess the association between participants’ serostatus and sexual violence. HIV negative women in serodiscordant relationships (36.1±11.1 years, range: 19–65 years) were significantly older than either HIV positive women in serodiscordant relationships (32.2±9.0 years, range: 18–56 years), or HIV negative women in concordant relationships (32.3±11.0 years, range: 18–62), (p=0.033). Early age at sexual debut was associated with a 2.4-fold increased risk of experiencing sexual violence (OR 2.4, 95% CI 1.27–4.65). Based on unadjusted analysis, HIV positive women in discordant relationship were at highest risk for sexual violence compared to HIV negative women in discordant unions, and HIV negative women in negative concordant unions. HIV negative women in discordant relationships and those in concordant negative relationships showed no increased risk for sexual violence. However, couples’ HIV serostatus was not significant related to incident sexual violence after controlling for potential confounding covariates. Nevertheless, the results were able to elucidate the sexual violence risk factor profile of participants based on couples’ HIV serostatus. Couple counseling protocols at HIV voluntary counseling and testing centers in Uganda should identify those at risk for sexual violence and develop interventions to reduce its incidence.
Body weight satisfaction among New Zealand adolescents: findings from a national survey
Authors: Wood Amanda , Utter Jennifer , Robinson Elizabeth , Ameratunga Shanthi , Fleming Theresa , Denny Simon 
Published: November 2011

Abstract
Body dissatisfaction has been extensively studied but, recently, the importance of body satisfaction and its attributing factors has received significant recognition. Also, there is an increasing awareness of the need for research examining body dissatisfaction and satisfaction in youth other than North American females. Thus, the current research examined the prevalence of, and the individual, social, and familial factors associated with, body-weight satisfaction among New Zealand male and female adolescents (n=9107). Data were analysed from Youth ’07, a nationally representative survey of New Zealand secondary school students. Overall, half of students were happy with their weight, with significantly more males than females reporting body-weight satisfaction. Students happiest with their weight were most likely to report healthy and supportive social and family environments, as well as higher levels of well-being. These findings are consistent with a growing body of research that suggests creating positive peer and family environments may lead to better developmental outcomes, such as body satisfaction, and also higher levels of well-being.
Intra-abdominal hyaluronan concentration in peritoneal fluid of horses with sudden signs of severe abdominal pain
Authors: Lillich James D. , Ray-Miller Wendy , Silver Kristopher S. , Davis Elizabeth G. , Schultz Bruce D. 
Published: November 2011

Abstract
Objective—To determine hyaluronan concentrations in peritoneal fluid from healthy horses and horses with sudden signs of severe abdominal pain and to identify the cellular sources of hyaluronan within the peritoneal cavity.
Animals—7 client-owned horses that were evaluated for sudden signs of severe abdominal pain, 6 healthy teaching horses, and 13 euthanized horses (11 with no abdominal disease and 2 that had undergone abdominal surgery 2 weeks previously for a different study).
Procedures—Abdominal fluid was collected from the client-owned and teaching horses. Hyaluronan concentrations were determined with an ELISA. Equine mesothelial cells were aseptically harvested from euthanized horses immediately after euthanasia, cultured, and processed for western blot immunoassays to detect expression of the following mesothelial cell markers: cytokeratins 8 and 18, vimentin, calretinin, mesothelin, and CD44. A reverse transcriptase–PCR assay was used to detect genetic expression of hyaluronan synthase-2 (HAS-2) from cultured and native equine tissue.
Results—The mean ± SD abdominal hyaluronan concentration in peritoneal fluid from horses with signs of abdominal pain (1,203.3 ± 46.3 ng/mL) was significantly greater than that in healthy horses (228.4 ± 167.3 ng/mL). Harvested cells were maintained, and immunoblotting analyses confirmed expression of the mesothelial markers. Gene expression of HAS-2 from cultured mesothelial cells and fibroblasts was confirmed.
Conclusions and Clinical Relevance—Peritoneal hyaluronan concentration was much higher in horses with severe abdominal pain than in healthy horses. Cultured equine mesothelial cells and fibroblasts can produce hyaluronan through HAS-2. Future investigation should focus on establishing the effect of exogenous hyaluronan administration on mesothelial cell function in horses with abdominal disease.
The sinkhole enigma in the Alpine Foreland, Southeast Germany: Evidence of impact-induced rock liquefaction processes
Authors: Ernstson Kord , Mayer Werner , Neumair Andreas , Sudhaus Dirk 
Published: November 2011

AbstractSudden collapse of the Quaternary soil to form sinkholes on the order of meters and tens of meters has been a geologic phenomenon within living memory in a localized area north of Lake Chiemsee in Southeast Germany. Failing a satisfying explanation, a relation with an undefined glaciation process has always been proposed. Excavations and geophysical measurements at three newly affected sites show underground features such as prominent sandy-gravelly intrusions and extrusions typical of rock liquefaction processes well known to occur during strong earthquakes. Since strong earthquakes can reasonably be excluded to have affected the area under discussion, it has been suggested that the observed widespread liquefaction is related with the recently proposed Holocene Chiemgau meteorite impact event. Except for one earlier proposed but unassertive relation between impact and liquefaction, the obviously direct association of both processes in the Chiemgau area emphasizes that observed paleoliquefaction features need not necessarily have originated solely from paleoseismicity but can provide a recognizable regional impact signature.
Ultrasound Assessment of the Internal Anal Sphincter in Women with Fecal Incontinence and Posterior Vaginal Wall Prolapse (Rectocele)
Authors: Kamel Hossam H , Serour Ahmad G , Mousa Laila AS 
Published: November 2011

ABSTRACT
Rupture of the internal anal sphincter (IAS) causes its weakness and it will not withstand increases of abdominal pressure, and fecal incontinence (FI) will occur. Recently, we put forward a novel concept on the physiology of defecation. Defecation is divided into two stages: First stage before training and second stage starts at the age of about 2 years, when the mother starts to teach her child how to hold up himself. This is gained by maintaining high alpha-sympathetic tone at the IAS, thus keeping it closed all the time till there is a need to pass stool or flatus, and the time and place are convenient. On defecation, six neuromuscular actions take place under the control of the CNS: (1) The person will relax the external anal sphincter, (2) he will lower the gained high alpha-sympathetic tone at the IAS, thus opening the anal canal, (3) he will relax the pelvic floor muscles bringing the rectum and the anal canal into one axis, (4) the abdominal and diaphragmatic muscles contract to increase the abdominal pressure, (5) the muscles of the distal colon and rectum contract pushing the stool, (6) sequential contractions of the three parts of the external anal sphincter (EAS) that squeeze any residual contents in the anal canal. Thus, the anal canal is closed and empty under normal circumstances. The IAS is a collageno-muscular tissue cylinder that surrounds the anal canal.
The IAS is intimately related to the posterior vaginal wall, and the vagina is over stretched in labor, childbirth trauma affects both the posterior vaginal wall and the IAS. Rupture of the collagen sheet of the IAS which causes its weakness is better demonstrated by imaging by 3D US.
Normal vagina is a cylinder of collageno-elastic-muscular tissues. Its strong collagen sheet is responsible for keeping it in its normal upward position. Labors cause redundancy and weakness of the vaginal walls with subsequent prolapse; and lacerations of the IAS which is closely related to the posterior vaginal wall leading to FI.
Cervical Consistency Index: A New Concept in Uterine Cervix Evaluation
Authors: Parra-Saavedra Miguel A , Gómez Libardo A , Barrero Amanda , Parra Guido , Vergara Felipe , Diaz-Yunez Israel , Gómez Martha , Bermúdez Carlos , Kontopoulos Eftichia V , Quintero Rubén A 
Published: November 2011

ABSTRACTObjectiveTo search an ultrasonographic marker to measure cervix consistency throughout pregnancy quantitatively by transvaginal ultrasonography and compare these values with the current pattern–the cervicometry. In a randomly selected population of pregnant and nonpregnant women using a new cervical consistency index (CCI) and compare these changes with the findings using cervicometry.MethodsThe cervical consistency index (CCI) and cervicometry were measured using transvaginal ultrasonography in a reference population of randomly selected women who were mature enough for reproduction, and women in their first, second and third trimester of pregnancy. Patients with history of cervical conization, two or more dilations and miscarriages, Müllerian abnormalities and history of cervix incompetence were excluded from this study. Furthermore, patients with multiple pregnancies and cervical cerclage were not allowed to participate in this study.ResultsA total of 162 patients were evaluated for cervicometry and CCI. Eighty of these women were not pregnant and the remaining 82 were pregnant. The database was analyzed using EPI-INFO version 6.0. Statistical values, such as the average, median and standard deviation between two groups, were analyzed. Statistically significant differences were found between nonpregnant and pregnant women in the first, second and third trimester regarding CCI with p < 0.0001. The cervix of pregnant women loses an average of 1.2% of consistency per week of pregnancy. Cervicometry did not show statistically significant difference among the groups (p = 0.4459).ConclusionCCI can quantitatively assess cervix consistency in pregnant and nonpregnant women, also found statistically significant differences between these groups and between the different trimesters of gestation, CCI also shows a remarkably circumscribed linear regression trend from early pregnancy. This ultrasound marker may serve in future for the early identification of patients at risk for preterm delivery. On cervicometry, there was no statistically significant differences between groups mentioned above.
Spontaneous Unilateral Tubal Twin Ectopic Pregnancy: A Case-Based Discussion and Assessment
Authors: Vallabh-Patel Vaneesha , Vera Robert , Martell Gustavo 
Published: November 2011

ABSTRACT

Introduction
Two percent of all 1st trimester pregnancies in the United States are ectopic. Transvaginal ultrasound is considered the mainstay in diagnosis. Color Doppler ultrasound can prove to be an added helpful modality in identifying ectopic pregnancies.

Case report
An 18-year-old nulliparous female presented with vaginal bleeding and lower abdominal pain. Pelvic exam revealed tenderness in the right adnexal region with elevated quantitative serum beta-hCG. A transvaginal ultrasound showed an echogenic ring adjacent to the right ovary and M-mode and color Doppler revealed two fetal heart tones. Color Doppler enabled visualization of randomly dispersed tubal arteries and heart activity of both embryos. A right salpingectomy was performed without complications and beta hCG levels returned to undetectable levels.

Conclusion
B mode ultrasound is a vital diagnostic tool in the detection of ectopic pregnancy. Color Doppler provides both morphologic and functional information essential for determining the optimal therapeutic strategy. Three-dimensional ultrasound with color and/or power Doppler has proven useful in both the initial diagnosis and follow-up of ectopic pregnancies especially in patients following assisted reproduction treatment.