bluuebunny/crossref_metadata_2025_split huggingface dataset:
HDAC1 acts as tumor suppressor in ALK-positive anaplastic large-cell lymphoma: Implications for HDAC inhibitor therapy
Authors: Zrimšek Maša , Draganić Kristina , Malzer Anna , Doblmayr Verena , de Freitas e Silva Rafael , Wohlhaupter Sabrina , Perez Malla Carlos Uziel , Mišura Katarina , Fischer Heinz , Schachner Helga , Schiefer Ana-Iris , Sheibani-Tezerji Raheleh , Ellmeier Wilfried , Seiser Christian , Egger Gerda 
Published: June 2024

ABSTRACTHistone deacetylases (HDACs) play essential roles in T cell development, and several HDAC inhibitors (HDACi) have gained approval for treating peripheral T cell lymphomas. In this study, we investigated the effects of genetic or pharmacological HDAC inhibition on NPM-ALK positive anaplastic large cell lymphoma (ALCL) development to elucidate potential contraindications or indications for the use of HDACi for the treatment of this rare T-cell lymphoma. Short-term systemic pharmacological inhibition of HDACs using the class I-specific HDACi Entinostat in a premalignant ALCL mouse model postponed or even abolished lymphoma development, despite high expression of the NPM-ALK fusion oncogene. To further disentangle the effects of systemic HDAC inhibition from thymocyte intrinsic effects, conditional genetic deletions of highly homologous class I HDAC1 and HDAC2 enzymes were employed. In sharp contrast to the systemic inhibition, T cell-specific deletion ofHdac1orHdac2in the ALCL mouse model significantly accelerated NPM-ALK-driven lymphomagenesis, withHdac1loss having a more pronounced effect. Integration of gene expression and chromatin accessibility data revealed thatHdac1deletion selectively perturbed cell type specific transcriptional programs, crucial for T cell differentiation and signaling. Moreover, multiple oncogenic signaling pathways, including PDGFRB signaling, were highly upregulated. The accelerated lymphomagenesis primarily depended on the catalytic activity of HDAC1, as the expression of a catalytically inactive HDAC1 protein showed similar effects to the complete knockout. Our findings underscore the tumor-suppressive function of class I HDAC1 and HDAC2 in T cells during ALCL development, however systemic pharmacological inhibition of HDACs is still a valid treatment strategy, which could potentially improve current therapeutic outcomes.
Transcription network of SLC7A11 (xCT) in colon cancer provides clinical targets for metabolic regulation and cell proliferation
Authors: Zohar Keren , Wartmann Thomas , Strecker Marco , Doelling Maximilian , Andric Mihailo , Shi Wenjie , Croner Roland S , Kakhlon Or , Zhao Yue , Kahlert Ulf D , Linial Michal 
Published: June 2024

AbstractColorectal cancer (CRC) represents the third leading cause of cancer-related deaths. Knowledge covering diverse cellular and molecular data from individual patients has become valuable for diagnosis, prognosis, and treatment selection. Here, we present in-depth comparative RNA-seq analysis of 32 CRC patients pairing tumor and healthy tissues (total of 73 samples). Strict thresholds for differential expression genes (DEG) analysis revealed an interconnection between nutrients, metabolic program, and cell cycle pathways. Among the upregulated DEGs, we focused on the Xc- system, composed of the proteins from SLC7A11 (xCT) and SLC3A2 genes, along with several interacting genes. To assess the oncogenic potency of the Xc- system in a cellular setting, we applied a knowledge-based approach, analyzing gene perturbations from CRISPR screens. The study focused on a set of 27 co-dependent genes that were strongly correlated with the fitness of SLC7A11 and SLC3A2 across many cell types. Alterations in these genes in 13 large-scale studies (e.g., by mutations and copy number variation) were found to enhance overall survival and progression-free survival in CRC patients. In agreement, the overexpression of these genes in cancer cells drives cancer progression by allowing effective management of the redox level, induction of stress response mechanisms, and most notably, enhanced activity of ion/amino acid transporters, and enzymes acting in de novo nucleotide synthesis. We also highlight the positive correlation between the Xc- system gene expression level, patient responsiveness to different chemotherapy treatments, and immune cell infiltration (e.g.,myeloid-derived suppressor cells) in CRC tumors as a measure for their immunosuppressive activity. This study illustrates that knowledge-based interpretation by synthesizing multiple layers of data leads to functional and mechanistic insights into the role of SLC7A11 and its associated genes in CRC tumorigenesis and therapeutics.
Motivation on training transfer: a moderated moderation model of personal capacity for transfer and gender
Authors: Gara Bach Ouerdian Emna 
Published: June 2024

Purpose
Previous research suggests that motivation to transfer is related to the effective transfer of training, but less is known about the boundary conditions of this relationship. Therefore, this study aims to propose that motivation to transfer is more strongly related to training transfer when employees have a stronger personal capacity for transfer. The author also hypothesizes that this two-way interaction is further moderated by gender.

Design/methodology/approach
Using a cross-sectional design and a sample of 257 Tunisian workers, a three-way interaction model with the PROCESS macro (Hayes, 2018) was used to test the hypotheses.

Findings
Results show that workers respond to motivation to transfer with increased training transfer. Personal capacity for transfer and gender moderated the proposed relationship. Thus, the interaction effect between motivation to transfer and personal capacity for transfer is significant for women but not significant for men. More specifically, motivation to transfer is more likely to predict training transfer among women with high personal capacity for transfer than among those with low.

Originality/value
This study adds to the literature on motivation to transfer and training transfer by explaining two boundary conditions in this relationship and by recognizing the conditional interaction effect of gender on the moderating effect of personal capacity for transfer.
Research trends in memes: insights from bibliometric analysis
Authors: Kamath Charunayan , Alur Sivakumar 
Published: June 2024

Purpose
The growth of social media globally has led to brands adopting memes as a tool for communication. They have influenced digital culture, politics and marketing. This study aims to highlight the research gap in meme literature by profiling and science mapping.

Design/methodology/approach
This study has performed a bibliometric analysis of research papers on memes from the Scopus database. The authors profiled the literature and found the most relevant journal, author and document. Science mapping techniques such as thematic analysis, thematic evolution and co-citation of papers with content analysis were used.

Findings
Profiling of literature revealed that the most relevant journal, based on a number of papers and citations, is New Media and Society. The top researcher on memes is Shiffman L (seven papers), and the most cited author is Menczer F (717 citations). The paper titled “Towards A Unified Science of Cultural Evolution” has the highest number of citations (402). Thematic mapping revealed “Social Movements” and “Twitter” are the currently trending themes. The co-citation analysis clustered the literature into two. The first cluster elucidates the theoretical underpinnings of memes, while the second cluster explicates the various contexts in which memes are studied.

Practical implications
This study will be vital to researchers hoping to study internet memes by providing directions for future research. Furthermore, the insights from this study will enable social media managers to use memes effectively.

Originality/value
To the best of the authors’ knowledge, this study seems to be the first to use bibliometric analysis to profile and map meme literature. This study provides a new perspective for meme researchers to explore memes and suggests marketers implement novel meme-based strategies in their marketing communications.
Masculinity in Scandinavian tech entrepreneurship: male technology entrepreneurs negotiating gender (in)equality
Authors: Balkmar Dag , Lindvert Marta , Ljunggren Elisabet Carine 
Published: June 2024

PurposeBoth entrepreneurship and technology are significantly gendered, and when combined in technology entrepreneurship, they make up a fundamentally masculine field. This article investigates men tech entrepreneurs' negotiations of gender and gender (in)equality. The purpose is to gain knowledge on masculinity in tech entrepreneurship and to explore what role this might play in any change towards more gender-equal entrepreneurship.Design/methodology/approachSemi-structured interviews were conducted with ten Swedish and Norwegian male tech entrepreneurs in tech incubators. The interviews dealt with gender (in)equality and masculinity in tech entrepreneurship. The data were coded in NVivo and inductively analysed using thematic analysis. We apply a social constructivist understanding of gender.FindingsWe categorise the male entrepreneurs' views of gender equality along “privileged”, “paradoxical” and “potential” articulations of gender (in)equality. Building on these articulations, we discuss the potential entrepreneurial men and masculinities could have for changing gender inequality in the Scandinavian tech entrepreneurship context. The findings are applicable to several entrepreneurial contexts.Originality/valueThe study contributes to further the theoretical understanding of tech entrepreneurship as a gendered phenomenon, its dynamics and its potential for change, particularly in promoting gender equality in tech entrepreneurship. Empirically, it investigates the perceptions about gender (in)equality and gender as negotiated concepts amongst male tech entrepreneurs.
Conditional accounting conservatism and financial flexibility: the Corona pandemic in the formation of legal claims
Authors: Mahmoodi Ali Asghar , Abdoli Mohammadreza , Shahri Maryam , Dehdar Farhad 
Published: June 2024

Purpose
The purpose of this research is to investigate the importance and status of conditional accounting conservatism indicators and financial flexibility for the management of legal claims of the company during the outbreak of Corona.

Design/methodology/approach
The research method was implemented using statistical analysis in the SPSS environment. The participants of this research can be experts and specialists working in companies admitted to the stock exchange and expert professors in accounting fields; auditing; economy; financial engineering and financial management, categorized. The data related to the localization tool of research variables were collected by snowball sampling method in the summer of 2022.

Findings
One of the main results of the research is that based on the opinions and professional experience of experts and professionals working in companies admitted to the stock exchange and academic experts, within a range of seven, “The number of legal claims of the company with electronic businesses” under the title of the main indicator in the legal claims of the company in the outbreak of Corona from the importance dimension; “Exchange rate fluctuations in financial resilience” under the title of the main indicator in financial resilience in the Corona outbreak from the functional dimension; “The number of legal claims of the company with government institutions” under the title of the main indicator in the company’s legal claims in the Corona outbreak from the functional dimension; “The company’s conservatism score” under the title of the main indicator in the conditional conservatism of accounting in the Corona outbreak from the functional dimension; “oil price fluctuations in financial resilience” under the title of the main indicator in financial resilience in the Corona outbreak from the importance dimension; and “type of industry based on total assets” under the title of the main indicator in the conditional conservatism of accounting in the Corona outbreak was calculated from the importance dimension.

Originality/value
Although the previous literature has studied the direct correlation between accounting conservatism and financial flexibility, this work focuses on examining the direct association between accounting conservatism and financial flexibility in the post-Corona era and is carried out to resolve legal claims.
A bibliometric analysis on gamifying adult learning: past, present and future trends of learner-centered pedagogies
Authors: Por Fei Ping , Ong Christina Sook Beng , Ng Siew Keow , Din Eak Arathai 
Published: June 2024

Purpose
The psychological theory of self-determination postulated that gamification enhances learning engagement by intrinsically motivating learners to undertake tasks spontaneously. Gamification has then been integrated into adult learning as part of the initiative of learner-centred pedagogies to curb the low retention rates of adult learners who struggle with heavy work commitments, family obligations and financial pressure. Gamification, being one of the technological mediations, assumes the crucial role of engaging and retaining adult learners. Adult learners have received less attention in research when compared with conventional university students. The purpose of this study is to conduct a bibliographic analysis to assess the past, present and future publication trends of gamifying adult learning and to identify the research gap.

Design/methodology/approach
This study included publications related to gamification and adult learning from 2014 to 2022, extracted from Dimensions. A total of 79,864 publications were retrieved initially, and 3,469 publications were ultimately selected for final analysis after the refinement of the keyword search. VOSviewer was used for bibliographic coupling, keyword co-occurrence, clustering and co-citation analysis of countries.

Findings
The number of publications related to gamification in adult learning has decreased since its peak in 2020. The saturation is mainly concentrated in the USA, the UK and China, with similar levels of national income and technology advancement skills. However, gamification in adult learning remains a popular and growing research area in developing countries like Malaysia, which has huge potential due to government investments in education, technology and lifelong learning. There is also an evident research gap on gamification, adult learning and personality traits, which have not been covered in previous studies.

Originality/value
Prior research mostly focused on systematic literature reviews, while the use of bibliometric analysis could be a missing link in this research domain. This paper unveils the evolution of publications on this topic over time by scientifically analysing a large number of publications and rigorously identifying research gaps contributing to future research avenues.
Bank fundamental dynamics: the role of optimal bank management
Authors: Ariefianto Moch. Doddy , Sutanto Tasha , Jesslyn Cecilia 
Published: June 2024

Purpose
This study aims to investigate the dynamic relationships between profitability, credit risk, liquidity risk and capital in Indonesian banking industry.

Design/methodology/approach
The authors use a panel vector autoregression model that incorporates macroeconomic variables: growth, interest rate, foreign exchange. The analysis is based on a monthly panel data set of 88 banks spanning from January 2012 to September 2021, which comprises 10,296 bank-month observations.

Findings
Our key findings highlight (i) permanent credit cost and liquidity cost pass through practices, (ii) complementary function of liquidity and capital, (iii) earning management motivated asset write off and (iv) credit risk-liquidity risk neutrality. In addition, the authors observe that the banks demonstrated resilience to macroeconomic shocks.

Research limitations/implications
Our study have shown some interesting dynamic patterns of fundamentals; nevertheless, unified theoretical underpinning of the process is still unavailable. This should be an important future reasearch avenue.

Practical implications
The study brings significant implications for regulatory and supervisory practices aimed at enhancing the financial stability of banks.

Originality/value
We conduct estimation of Indonesian banks system in dynamic perspective and perform impulses responses.
Campus entrepreneurs’ research habits and needs: a five-year study
Authors: Toane Carey , Shujah Sarah 
Published: June 2024

PurposeThis study surveyed the entrepreneurship community on a large university campus in 2016 and in 2020 to identify and understand its information habits and needs. User needs can inform service design and assessment, as well as inform approaches to reference interactions. Librarians are encouraged to conduct similar surveys to better understand this niche population.Design/methodology/approachInvestigators employed repeated cross-sectional design, a longitudinal research approach that draws on samples of non-overlapping or minimally overlapping cases over time. Qualitative and quantitative data were collected using online survey instruments. Data collected included demographic information, venture characteristics, participation in institutional activities such as accelerator programs and credit courses, general startup research behaviors and needs, and details of a specific instance of business or market research as well as interaction with the library and access to training. Triangulation of semantic and episodic was applied to draw reliable conclusions about respondent behavior.FindingsIn both surveys, over half of respondents were students and 75% of respondents were engaged in startup activity, most at the early stages. While respondent demographics, type and purpose of information sought remained constant between the two surveys, awareness and use of the library rose on several metrics. Coding revealed insights into respondents’ attitudes toward and strategies for secondary business research. Information obtained during the research process had a moderate impact on their ventures. These findings informed the development of library research and instruction services, programs, and collections for entrepreneurs.Originality/valueThe repeated cross-sectional design of the study is unique and shows trends in the community over time. The mixed-methods approach provides a robust and nuanced portrait of the community. These findings informed the development and assessment of library research and instruction services, programs and collections for entrepreneurs.
Accuracy of sonographic lower segment thickness and prediction of vaginal birth after caesarean in a resourced‐limited setting; Prospective study
Authors: Adu‐Takyi Charles , Munazzah Rafique , Owusu Yaw Gyanteh , Owusu‐Bempah Atta , Arhin Bernard , Opare‐Addo Henry Sakyi , Peprah Amponsah , Collins Sally L. , Adu‐Bredu Theophilus 
Published: June 2024

AbstractObjectivesTo assess the accuracy of ultrasound measurement of the lower uterine segment (LUS) thickness against findings at laparotomy, and to investigate its correlation with the success rate of vaginal birth after one previous caesarean delivery (CD) in a resource‐limited setting.DesignProspective study.SettingObstetrics and Gynaecology department in a tertiary hospital in Ghana.PopulationWomen with one previous CD undergoing either a trial of labour (TOLAC) or elective CD.MethodsMyometrial lower uterine segment thickness (mLUS) and full lower uterine segment thickness (fLUS) were measured with transvaginal ultrasound (TVUS). The women were managed according to local protocols with the clinicians blinded to the ultrasound measurements. The LUS was measured intraoperatively for comparison with ultrasound measurements.Main outcome measuresLower uterine segment findings at laparotomy, successful vaginal birth.ResultsA total of 311 pregnant women with one previous CD were enrolled; 147 women underwent elective CD and 164 women underwent a TOLAC. Of the women that underwent TOLAC, 96 (58.5%) women had a successful vaginal birth. The mLUS was comparable to the intraoperative measurement in the elective CD group with LUS thickness <5 mm (bias of 0.01, 95% CI −0.10 to 0.12 mm) whereas fLUS overestimated LUS <5 mm (bias of 0.93, 95% CI 0.80–1.06 mm). Successful vaginal birth rate correlated with increasing mLUS values (odds ratio 1.30, 95% CI 1.03–1.64). Twelve cases of uterine defect were recorded. LUS measurement ≤2.0 mm was associated with an increased risk of uterine defects with a sensitivity of 91.7% (95% CI 61.5–99.8%) and specificity of 81.8% (95% CI 75.8–86.8%).ConclusionAccurate TVUS measurement of the LUS is technically feasible in a resource‐limited setting. This approach could help in making safer decisions on mode of birth in limited‐resource settings.
Effect of mental health staffing inputs on initiation of care among recently separated Veterans
Authors: Shafer Paul R. , Yuan Yingzhe , Feyman Yevgeniy , Price Megan E. , Kabdiyeva Aigerim , Figueroa Stuart M. , Shen Yi‐Jung , Nebeker Jonathan R. , Ward Merry C. , Strombotne Kiersten L. , Pizer Steven D. 
Published: June 2024

AbstractObjectiveTo estimate a causal relationship between mental health staffing and time to initiation of mental health care for new patients.Data Sources and Study SettingAs the largest integrated health care delivery system in the United States, the Veterans Health Administration (VHA) provides a unique setting for isolating the effects of staffing on initiation of mental health care where demand is high and out‐of‐pocket costs are not a relevant confounder. We use data from the Department of Defense and VHA to obtain patient and facility characteristics and health care use.Study DesignTo isolate exogenous variation in mental health staffing, we used an instrumental variables approach—two‐stage residual inclusion with a discrete time hazard model. Our outcome is time to initiation of mental health care after separation from active duty (first appointment) and our exposure is mental health staffing (standardized clinic time per 1000 VHA enrollees per pay period).Data Collection/Extraction MethodsOur cohort consists of all Veterans separating from active duty between July 2014 and September 2017, who were enrolled in the VHA, and had at least one diagnosis of post‐traumatic stress disorder, major depressive disorder, and/or substance use disorder in the year prior to separation from active duty (N = 54,209).Principal FindingsAn increase of 1 standard deviation in mental health staffing results in a higher likelihood of initiating mental health care (adjusted hazard ratio: 3.17, 95% confidence interval: 2.62, 3.84, p < 0.001). Models stratified by tertile of mental health staffing exhibit decreasing returns to scale.ConclusionsIncreases in mental health staffing led to faster initiation of care and are especially beneficial in facilities where staffing is lower, although initiation of care appears capacity‐limited everywhere.