bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of Dialysis Access-Associated “Steal” Syndrome with DRIL Procedure: Challenges and Clinical Outcomes
Authors: Anaya-Ayala Javier E. , Pettigrew Candace D. , Ismail Nyla , Diez-De Sollano Ana L. , Syed Fahad A. , Ahmed Farhan G. , Davies Mark G. , Peden Eric K. 
Published: January 2012

Purpose The Distal Revascularization Interval-Ligation (DRIL) procedure has demonstrated efficacy in the management of Dialysis Access-associated Steal Syndrome (DASS); however, this has not been widely used because of concerns about complexity, risk of ligating a native artery, and lack of long-term outcomes. Methods Retrospective review of all patients with DASS who underwent DRIL procedure from March 2005 to August 2011. Indications, clinical considerations, bypass grafts, and patency rates were determined; complications, reinterventions, and factors influencing their outcomes were studied. Results 33 patients, (70% women, mean age of 56 ± 13) with DASS underwent a DRIL. Indications were ischemic pain alone in 12 (36%) patients, loss of neurologic function in 7 (21%), both ischemic pain and loss of neurologic function in 4 (12%) tissue loss in 7 (21%), pain during hemodialysis in one (3%), and “prophylactic” DRIL during a Femoral Vein transposition (FVt) fistula in two (6%). Technical success was 100%; Ischemic symptoms fully resolved by DRIL in 24 of the 31 symptomatic patients (77%) and during the follow up period DASS did not develop in the subjects we judged at high risk and underwent DRIL during FVt. One serious complication occurred because of early bypass thrombosis causing worsening hand gangrene requiring transmetacarpal amputation. The primary, assisted-primary, and secondary patency rates of the arterial bypass at 12 months were 65%, 75%, and 95% respectively. AV access primary, assisted-primary, and secondary patency were 29%, 85%, and 94% at 12 months. Conclusions DRIL procedure is effective at relieving symptoms in carefully selected patients, but does have potential complications such as bypass failure and worsened ischemia. DASS remains a complex clinical entity in that it is not fully understood, and deserves further study.
The Macbride Principles
Authors: McNamara Kevin 
Published: January 2012

Published in November 1984, The MacBride Principles contained nine affirmative action proposals aimed at eliminating religious discrimination in the employment practices of United States corporations with subsidiaries in Northern Ireland. The weapon used by the MacBride campaigners was the federal constitution of the United States. States and cities in the Union could pass their own corporate legislation incorporating the MacBride Principles and use their pension fund investments to table shareholder resolutions seeking the Principles inclusion in employment policies. Later developments saw their application to US and foreign firms supplying goods and services to states and cities. Using devolved legislation, the MacBride Campaign broke the stranglehold on the discussion of Irish issues maintained by the US, UK and Irish governments in the Congress. It was debated in state legislatures and city councils. Irish-America was motivated to participate in a nonviolent campaign to achieve social justice in Northern Ireland. Supported by the United States government, there was a fierce reaction by the British government to the Principles. Its attempts to suppress them were unsuccessful. Using interviews with key personalities involved and hitherto unpublished and inaccessible archives of the Department of Foreign Affairs, Dublin, and papers obtained using the Freedom of Information Acts of the United States the United Kingdom, the evolution of the McBride Campaign is mapped out in full by Kevin McNamara, who brings particular insight through is role as a British Member of Parliament and former Shadow Secretary of State for Northern Ireland.
Association Between Cost Sharing and Naloxone Prescription Dispensing
Authors: Chua Kao-Ping , Conti Rena M. , Lagisetty Pooja , Bohnert Amy S. , He Sijia , Nguyen Thuy D. 
Published: June 2024

ImportanceIncreasing access to naloxone (an opioid antagonist that can reverse overdose) could slow the US opioid epidemic. Prior studies suggest cost sharing may be a barrier to dispensing of naloxone prescriptions, but these studies were limited by their cross-sectional designs and use of databases that do not capture prescriptions that are not filled (abandoned).ObjectiveTo evaluate the association between cost sharing and naloxone prescription abandonment (nondispensing of naloxone prescriptions).Design, Setting, and ParticipantsThis cross-sectional, regression discontinuity analysis exploited the fact that deductibles typically reset at the beginning of the year in commercial and Medicare plans. The included data were derived from the 2020-2021 IQVIA Formulary Impact Analyzer (a pharmacy transactions database that represents 63% of prescriptions at US pharmacies). The analysis included claims for naloxone nasal spray among commercially insured patients and Medicare patients that occurred during the 60 days before January 1, 2021, through 59 days after January 1, 2021.ExposureCost sharing, which is defined as the amount patients would have to pay to fill prescriptions.Main Outcomes and MeasuresLocal linear regression models were used to assess for abrupt changes in cost sharing and the probability of prescription abandonment on January 1, 2021. To estimate the association between cost sharing and prescription abandonment, a fuzzy regression discontinuity analysis was conducted.ResultsThese analyses included naloxone claims for 71 306 commercially insured patients and 101 706 Medicare patients (40 019 [56.1%] and 61 410 [60.4%], respectively, were female). The commercially insured patients and Medicare patients accounted for 73 311 and 106 076 naloxone claims, respectively. On January 1, 2021, the mean cost sharing per claim increased by $15.0 (95% CI, $13.8-$16.2) for commercially insured patients and increased by $12.3 (95% CI, $10.9-$13.6) for Medicare patients and the probability of abandonment increased by 4.7 (95% CI, 3.2-6.2) percentage points and 2.8 (95% CI, 1.6-4.1) percentage points, respectively. The results from the fuzzy regression discontinuity analysis suggest a decision by commercial and Medicare plans to increase naloxone cost sharing by $10 would be associated with percentage-point increases of 3.1 (95% CI, 2.2-4.1) and 2.3 (95% CI, 1.4-3.2), respectively, in the probability of abandonment.ConclusionsThe elimination of cost sharing might be associated with increased naloxone dispensing to commercially insured and Medicare patients.
Well-Child Visits for Early Detection and Management of Maternal Postpartum Hypertensive Disorders
Authors: Amro Farah H. , Smith Kim C. , Hashmi Syed S. , Barratt Michelle S. , Carlson Rachel , Sankey Kristen Mariah , Bartal Michal Fishel , Blackwell Sean C. , Chauhan Suneet P. , Sibai Baha M. 
Published: June 2024

ImportanceInnovative approaches are needed to address the increasing rate of postpartum morbidity and mortality associated with hypertensive disorders.ObjectiveTo determine whether assessing maternal blood pressure (BP) and associated symptoms at time of well-child visits is associated with increased detection of postpartum preeclampsia and need for hospitalization for medical management.Design, Setting, and ParticipantsThis is a pre-post quality improvement (QI) study. Individuals who attended the well-child visits between preimplementation (December 2017 to December 2018) were compared with individuals who enrolled after the implementation of the QI program (March 2019 to December 2019). Individuals were enrolled at an academic pediatric clinic. Eligible participants included birth mothers who delivered at the hospital and brought their newborn for well-child check at 2 days, 2 weeks, and 2 months. A total of 620 individuals were screened in the preintervention cohort and 680 individuals were screened in the QI program. Data was analyzed from March to July 2022.ExposuresBP evaluation and preeclampsia symptoms screening were performed at the time of the well-child visit. A management algorithm—with criteria for routine or early postpartum visits, or prompt referral to the obstetric emergency department—was followed.Main Outcome and MeasuresReadmission due to postpartum preeclampsia. Comparisons across groups were performed using a Fisher exact test for categorical variables, and t tests or Mann-Whitney tests for continuous variables.ResultsA total of 595 individuals (mean [SD] age, 27.2 [6.1] years) were eligible for analysis in the preintervention cohort and 565 individuals (mean [SD] age, 27.0 [5.8] years) were eligible in the postintervention cohort. Baseline demographic information including age, race and ethnicity, body mass index, nulliparity, and factors associated with increased risk for preeclampsia were not significantly different in the preintervention cohort and postintervention QI program. The rate of readmission for postpartum preeclampsia differed significantly in the preintervention cohort (13 individuals [2.1%]) and the postintervention cohort (29 individuals [5.6%]) (P = .007). In the postintervention QI cohort, there was a significantly earlier time frame of readmission (median [IQR] 10.0 [10.0-11.0] days post partum for preintervention vs 7.0 [6.0-10.5] days post partum for postintervention; P = .001). In both time periods, a total of 42 patients were readmitted due to postpartum preeclampsia, of which 21 (50%) had de novo postpartum preeclampsia.Conclusions and RelevanceThis QI program allowed for increased and earlier readmission due to postpartum preeclampsia. Further studies confirming generalizability and mitigating associated adverse outcomes are needed.
Stereotactic Ablative Radiotherapy for Gynecological Oligometastatic and Oligoprogessive Tumors
Authors: Donovan Elysia K. , Lo Simon S. , Beriwal Sushil , Chen Hanbo , Cheung Patrick , Keller Andrew , Nwachukwu Chika , Mantz Constantine , Pond Gregory R. , Schnarr Kara , Swaminath Anand , Albuquerque Kevin , Leung Eric 
Published: June 2024

ImportanceThe role of stereotactic ablative radiotherapy (SABR) for gynecologic malignant tumors has yet to be clearly defined despite recent clinical uptake.ObjectiveTo evaluate the outcomes of SABR in patients with oligometastatic and oligoprogressive gynecologic cancers.Design, Setting, and ParticipantsIn this retrospective pooled analysis, patients with oligometastatic and oligoprogressive gynecologic cancers receiving SABR at 5 institutions from Canada and the US were studied. Data were collected from January 2011 to December 2020, and data were analyzed from January to December 2023.ExposureStereotactic ablative radiotherapy.Main Outcomes and MeasuresCumulative incidence of local and distant recurrence, chemotherapy-free survival (CFS), and overall survival (OS) probabilities after SABR were calculated using Kaplan-Meier methods. Univariable and multivariable analysis was conducted using Cox regression methods.ResultsA total of 215 patients with 320 lesions meeting criteria were included in the analysis; the median (range) age at primary diagnosis was 59 (23-86) years. The median (range) follow-up from SABR was 18.5 (0.1-124.5) months. The primary site included the endometrium (n = 107), ovary (n = 64), cervix (n = 30), and vulva or vagina (n = 14). Local cumulative incidence of recurrence was 13.7% (95% CI, 9.4-18.9) and 18.5% (95% CI, 13.2-24.5) at 1 and 5 years, respectively. Distant cumulative incidence of recurrence was 48.5% (95% CI, 41.4-55.1) and 73.1% (95% CI, 66.0-79.0) at 1 and 5 years, respectively. OS was 75.7% (95% CI, 69.2-81.1) and 33.1% (95% CI, 25.3-41.1) at 1 and 5 years, respectively. The median CFS was 21.7 months (95% CI, 15.4-29.9). On multivariable analysis, local recurrence was significantly associated with nodal metastasis, lesion size, biologically effective dose, treatment indication, institution, and primary disease type. Distant progression-free survival was associated with nodal targets and lesion size. OS and CFS were significantly associated with lesion size.Conclusions and RelevanceIn this study, SABR appeared to have excellent local control with minimal toxic effects in this large patient group, and certain patients may achieve durable distant control and OS as well. It may be possible to delay time to chemotherapy in select patient subtypes and therefore reduce associated toxic effects. Prospective multicenter trials will be critical to establish which characteristics procure the greatest benefit from SABR use and to define the ideal time to implement SABR with other oncologic treatments.
Home Time Among Older Adults With Acute Myeloid Leukemia Following Chemotherapy
Authors: Richardson Daniel R. , Zhou Xi , Reeder-Hayes Katherine , Jensen Christopher E. , Islam Jessica , Loh Kah Poh , Gupta Arjun , Basch Ethan , Bennett Antonia V. , Bridges John F. P. , Wheeler Stephanie B. , Wood William A. , Baggett Christopher D. , Lund Jennifer L. 
Published: June 2024

ImportancePatients with acute myeloid leukemia (AML) recognize days spent at home (home time) vs in a hospital or nursing facility as an important factor in treatment decision making. No study has adequately described home time among older adults with AML.ObjectiveTo describe home time among older adults with AML (aged ≥66 years) and compare home time between 2 common treatments: anthracycline-based chemotherapy and hypomethylating agents (HMAs).Design, Setting, and ParticipantsA cohort of adults aged 66 years or older with a new diagnosis of AML from the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database in 2004 to 2016 was identified. Individuals were stratified into anthracycline-based therapy, HMAs, or chemotherapy, not otherwise specified (NOS) using claims.Main Outcomes and MeasuresThe primary outcome was home time, quantified by subtracting the total number of person-days spent in hospitals and nursing facilities from the number of person-days survived and dividing by total person-days. A weighted multinomial regression model with stabilized inverse probability of treatment weighting to estimate adjusted home time was used.ResultsThe cohort included 7946 patients with AML: 2824 (35.5%) received anthracyclines, 2542 (32.0%) HMAs, and 2580 (32.5%) were classified as chemotherapy, NOS. Median (IQR) survival was 11.0 (5.0-27.0) months for those receiving anthracyclines and 8.0 (3.0-17.0) months for those receiving HMAs. Adjusted home time for all patients in the first year was 52.4%. Home time was highest among patients receiving HMAs (60.8%) followed by those receiving anthracyclines (51.9%). Despite having a shorter median survival, patients receiving HMAs had more total days at home and 33 more days at home in the first year on average than patients receiving anthracyclines (222 vs 189).Conclusions and RelevanceThis retrospective study of older adults with AML using SEER-Medicare data and propensity score weighting suggests that the additional survival afforded by receiving anthracycline-based therapy was entirely offset by admission to the hospital or to nursing facilities.
Longitudinal Trends and Disparities in Diabetic Retinopathy Within an Aggregate Health Care Network
Authors: Markle Jonathan , Shaia Jacqueline K. , Araich Harman , Sharma Neha , Talcott Katherine E. , Singh Rishi P. 
Published: June 2024

ImportanceDiabetic retinopathy (DR) is a leading cause of blindness in the US, warranting updates on its prevalence and incidence in the setting of advancements in diabetic care over recent years.ObjectiveTo determine recent trends in DR prevalence stratified by baseline demographics to identify those populations at greater risk.Design, Setting, and ParticipantsThis was a cross-sectional epidemiologic evaluation conducted using deidentified data from the large federated TriNetX Analytics health research network composed of 56 health care organizations in the US. Patients from 2015 to 2022 who had an International Statistical Classification of Diseases and Related Health Problems, Tenth Revision code of type 1 DR (T1DR) or type 2 DR (T2DR) were included in this analysis. Patients were further stratified by age cohorts (20-29 years, 30-39 years, 40-49 years, 50-59 years, 60-69 years, and 70 years or older), race and ethnicity, and sex.Main Outcomes and MeasuresPrevalence per 100 000 patients and prevalence odds ratios (ORs) were calculated in Microsoft Excel and Posit (formerly RStudio).ResultsA total of 359 126 patients with T1DR or T2DR (mean [SD] age, 67 [14] years; 52% female) were included in this study between January 1, 2015, and December 21, 2022. T1DR increased in prevalence from 2015 to 2022, with T1DR increasing 1.15-fold affecting 70.4 patients per 100 000 in 2022. T2DR increased 1.07-fold affecting 461.7 patients per 100 000 in 2022. For T1DR, the cohort aged 20 to 39 years had the most substantial increase at 4.7 and 1.96 fold. Overall, White males had the largest prevalence ORs of T1DR at 1.41 (95% CI, 1.36-1.47) compared with White females (reference group). In T2DR, patients aged 20 to 39 years again had a 2.5- and 1.6-fold prevalence increase from 2015 to 2022. Regardless of age group, Hispanic males demonstrated larger prevalence OR at 4.08 (95% CI, 3.97-4.19) compared with White females followed by Hispanic females at 2.49 (95% CI, 2.42-2.56), Black males at 2.23 (95% CI, 2.17-2.29), and Black females at 2.00 (95% CI, 1.95-2.05).Conclusion and RelevanceThe prevalence of both T1DR and T2DR increased in this network from 2015 to 2022, with individuals aged 20 to 39 years showing large increases. Additionally, T2DR was associated with greater increases in both Hispanic and Black communities. These findings support DR screening in young adults and for T2DR interventions specifically designed for racial and ethnic minoritized patients most affected by disease. Future investigations are warranted to further investigate these trends among young adults.
Enzyme‐Assisted Activation Technique for Producing Versatile Hydrogel Microparticle Scaffolds with High Surface Chemical Reactivity
Authors: Zhang Jing , Zeng Yunfeng , Heng Yongyuan , Shen Yu , Sun Ximeng , Wang Yijia , Zheng Haiping , Zeng Ming , Yu Ziyi 
Published: June 2024

AbstractAdvancing the integration of nonliving and living components relies heavily on functional hydrogel materials with biocompatibility and customizability. In this study, an enzyme‐assisted surface activation method is developed to produce reactive hydrogel microparticles (HMPs) comprising thiolated hyaluronic acid and hyperbranched poly(β‐hydrazide esters). Fluorescence labeling analysis reveals an over six‐fold increase in surface‐active functional group density on the hydrogels and three‐fold on HMPs after enzyme activation. This enhancement improves accessibility of active elements, facilitating post‐functionalization and optimizing their capacity to support initial cell adhesion and spreading as carriers for cell cultures. Additionally, by utilizing the exposed reactive double bonds on the HMP surfaces post‐enzymatic treatment, thiolated HMPs are produced through a thiol‐ene coupling reaction with thiolated polymers. These thiolated HMPs bond together spontaneously, resulting in the formation of annealed granular hydrogels with interconnected large‐pore networks and a tunable storage modulus (G’) from tens to hundreds of pascals, compatible with most soft tissues. Integrated with 3D bioprinting, this hydrogel ink generates prints that foster cell adhesion, migration, growth, and network formation. Moving forward, integrating various granular hydrogel scaffold systems with the enzyme‐assisted activation technique holds significant promise for enhancing performance and expanding applications in regenerative medicine and innovative living materials.
Access to β‐Lactam Sulfonamides from Sulfamoyl Chlorides via Photoredox Catalyzed C−S Bond Formation
Authors: Petek Nejc , Brodnik Helena , Grošelj Uroš , Svete Jurij , Štefane Bogdan 
Published: June 2024

AbstractSulfonyl chlorides are a synthetically attractive source of sulfonyl radicals in photoredox catalysis and are useful precursors in the synthesis of sulfones. Sulfamoyl chlorides, on the other hand, remain poorly represented despite their similar potential. In this study, N‐chlorosulfonylated β‐lactams were prepared from readily available precursors and utilized in an atom transfer radical addition (ATRA) reaction with a variety of olefins, producing β‐lactam sulfonamides in 49–95% yields. β‐Lactams fused to a dihydro‐1,2‐thiazine ring which closely resemble carbacephems, a widely used class of antibiotics, were also synthesized by an intra‐molecular ATRA reaction. This methodology enables the preparation of β‐lactam sulfonamides, a class of compounds that are of great interest in pharmacology.
Coupling of Induction with Damping Behavior for Viscosity Sensing via Design of Magnetized Oscillator
Authors: Liang Yuanzhe , Dai Ziyi , Ding Sen , Zhang Yuan , Zhou Yinning , Zhou Bingpu 
Published: June 2024

AbstractDetection of liquid viscosity is important from chemical engineering to daily safety. To match the emergence of internet of things, precise and fast viscosity determination is attracting intention in the society. However, most miniature viscometers face limitations such as high operation frequency, moving component, and non‐linear sensing, etc. Herein, a flexible viscometer is developed via coupling the electromagnetic induction with inherent oscillation of a magnetized oscillator. The mechanism allows vibration of the oscillator to be electrically reflected using damping signals. By analyzing the damping factor from viscosity‐dependent voltage profiles, viscosity of an unknown liquid can be accurately obtained. Furthermore, the 3D structures is developed with a dual‐template method, which enables convenient and high‐throughput preparations of devices with complex 3D structures. Via optimizing the structural and physical parameters, the “sphere” oscillator enables a linear relationship between the damping factor and the square root of viscosity for quantitative sensing in range of 0.01809–24.7 mPa s. The principle of electromagnetic induction renders the viscometer with superiorities of low operating frequency, remote sensing, self‐powered and chemical stability. It is expected that the methodology and damping dominant mechanism will serve as a promising platform for cost‐effective, portable and convenient viscosity detection for applications in diverse fluids.
Reversing MET‐Mediated Resistance in Oncogene‐Driven NSCLC by MET‐Activated Wnt Condensative Prodrug
Authors: Liu Na , Zheng Xiaoqiang , Yan Jin , Jiang Aimin , Yao Yu , He Wangxiao 
Published: June 2024

AbstractThe amplification of MET is a major cause of acquired resistance to targeted therapy in EGFR‐mutant non‐small‐cell lung cancer (NSCLC), only to be temporarily restrained by the partial efficacy of MET inhibitors. This study reveals that the MET inhibitor has unexpectedly limited efficacy due to amplified MET triggering a strong positive feedback loop in the Wnt/β‐catenin signaling pathway, allowing optimal functionality even when the MET pathway is suppressed again. To test this conjecture and specifically target the Wnt/β‐catenin pathway, a cleverly designed Wnt condensative pro drug called WntSI is developed using reversible supramolecular self‐assembly driven by liquidliquid phase separation (LLPS). This process involves a MET/pH‐responsive peptide (Tyr‐Pep) and a potent Wnt inhibitor known as CA. Upon recognition and phosphorylation of Tyr‐Pep by over expressed MET in cells, it disrupts LLPS propensity and facilitates the disintegration of WntSI. Consequently,this enables it to suppress the carcinogenic effect mediated by β‐catenin,effectively overcoming acquired resistance to EGFR‐TKIs caused by MET amplification in both cell line‐derived and patient‐derived tumor xenograft (PDX) mouse models while maintaining exceptional biosecurity. This effective strategy not only suppresses the Wnt/β‐catenin signaling pathway selectively, but also serves as an innovative example for pro‐drug development through biologically responsive LLPS.