bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of HSD3B1 and HSD3B2 gene polymorphisms with essential hypertension, aldosterone level, and left ventricular structure
Authors: Shimodaira Masanori , Nakayama Tomohiro , Sato Naoyuki , Aoi Noriko , Sato Mikano , Izumi Yoichi , Soma Masayoshi , Matsumoto Koichi 
Published: July 2010

BackgroundHSD3B1 and HSD3B2 are crucial enzymes for the synthesis of hormonal steroids, including aldosterone. Therefore,HSD3Bgene variations could possibly influence blood pressure (BP) by affecting the aldosterone level.MethodsWe performed a haplotype- and diplotype-based case–control study to investigate the association between theHSD3Bgene variations and essential hypertension (EH), aldosterone level, and left ventricular hypertrophy (LVH). A total of 275 EH patients and 286 controls were genotyped for four SNPs of theHSD3B1gene (rs3765945, rs3088283, rs6203, and rs1047303) and for two SNPs of theHSD3B2gene (rs2854964 and rs1819698). Aldosterone and LVH were investigated in 240 and 110 subjects respectively.ResultsSignificant differences were noted for the total and the male subject groups for the recessive model (CC versus TC+TT) of rs6203 between the controls and EH patients (P=0.030 andP=0.008 respectively). The frequency of the T-C haplotype established by rs3088283-rs1047303 was significantly higher for EH patients compared with the controls (P=0.014). Even though the polymorphism ofHSB3B1was not associated with LVH, the diplotype established by rs3088283-rs1047303 in the total subject group, along with the systolic BP, diastolic BP, and aldosterone level were significantly higher for those subjects who had the T-C haplotype versus those who did not (P=0.025,P=0.014, andP=0.006 respectively).Conclusionrs6203 and rs1047303 in theHSD3B1gene are useful genetic markers for EH, while polymorphisms ofHSD3B1are associated with the BP and aldosterone level.
Thyroid-associated ophthalmopathy; quality of life follow-up of patients randomized to treatment with antithyroid drugs or radioiodine
Authors: Abraham-Nordling Mirna , Wallin Göran , Träisk Frank , Berg Gertrud , Calissendorff Jan , Hallengren Bengt , Hedner Pavo , Lantz Mikael , Nyström Ernst , Åsman Peter , Lundell Göran , Törring Ove , _ _ 
Published: July 2010

ObjectiveThe objective of this study was to investigate quality of life (QoL) in patients with Graves' disease treated with radioiodine or antithyroid drugs.Design and methodsThe design of the study consists of an open, prospective, randomized multicenter trial between radioiodine and medical treatment. A total of 308 patients were included in the study group: 145 patients in the medical group and 163 patients in the radioiodine group. QoL was measured with a 36-item Short Form Health Status Survey questionnaire (SF-36) at six time points during the 48-month study period.ResultsPatient who developed or got worse of thyroid-associated ophthalmopathy (TAO) at any time point during the 4-year study period (TAO group) had lower QoL when no respect was paid to the mode of treatment.TAO occurred in 75 patients who had radioiodine treatment at some time point during the study period as compared with TAO in 40 medically treated patients (P<0.0009).Comparisons between the group of patients who have had TAO versus the group without TAO, in relation to treatments and time, showed significantly decreased QoL scores for the TAO groups at several time points during the study.In patients without TAO, there were no differences in QoL related to mode of treatment.ConclusionsThe QoL in patients with Graves' ophthalmopathy was similar in radioiodine and medically treated patients, but patients who developed or had worsening of TAO had decreased QoL independent of mode of treatment. Furthermore, patients with TAO recovered physically within 1 year but it took twice as long for them to recover mentally.
Occupational Risks and Challenges of Seafaring
Authors: Oldenburg Marcus , Baur Xaver , Schlaich Clara 
Published: July 2010

Occupational Risks and Challenges of Seafaring: Marcus Oldenburg, et al. Department of Maritime Medicine, Institute for Occupational and Maritime Medicine, Germany—Seafarers are exposed to a high diversity of occupational health hazards onboard ships.ObjectiveThe aim of this article is to present a survey of the current, most important hazards in seafaring including recommendations on measures how to deal with these problems.MethodsThe review is based on maritime expert opinions as well a PubMed analysis related to the occupational risks of seafaring.ResultsDespite recent advances in injury prevention, accidents due to harmful working and living conditions at sea and of non‐observance of safety rules remain a main cause of injury and death. Mortality in seafaring from cardiovascular diseases (CVD) is mainly caused by increased risks and impaired treatment options of CVD at sea. Further, shipboard stress and high demand may lead to fatigue and isolation which have an impact on the health of onboard seafarers. Communicable diseases in seafaring remain an occupational problem. Exposures to hazardous substances and UV‐light are important health risks onboard ships. Because of harsh working conditions onboard including environmental conditions, sufficient recreational activities are needed for the seafarers' compensation both onboard and ashore. However, in reality there is often a lack of leisure time possibilities.DiscussionSeafaring is still an occupation with specific work‐related risks. Thus, a further reduction of occupational hazards aboard ships is needed and poses a challenge for maritime health specialists and stakeholders. Nowadays, maritime medicine encompasses a broad field of workplaces with different job‐related challenges.
Blood Pressure Management in Patients With Diabetes
Authors: Salanitro Amanda H. , Roumie Christianne L. 
Published: July 2010

IN BRIEF
Patients with diabetes who also have hypertension are at increased risk of morbidity and mortality from cardiovascular events. However, blood pressure control is frequently suboptimal in the primary care setting. Large clinical trials support the use of antihypertensive medications in these patients to reduce the risk of cardiovascular disease and death.
Effect of Ozone Exposure on Growth, Yield and Isoprene Emission from Tomato (Lycopersicon esculentum L.) Plants
Authors: Mina Usha , Kumar Pranav , Varshney C. 
Published: July 2010

Effect of Ozone Exposure on Growth, Yield and Isoprene Emission from Tomato (Lycopersicon esculentum L.) Plants
Effect of ozone on three different growth phase of tomato (Lycopersicon esculentum cv. Pusa ruby) crop namely, Early Vegetative Phase (EVP), 30 days old plants; Late Vegetative Phase (LVP), 45 days old plants; and Fruiting Phase (FP), 60 days old plants were exposed to ozone concentrations (75 ppb and 150 ppb) in closed top dynamic chambers for 12 days period. Ozone exposed tomato plants of all the three growth stages exhibited visible injury symptoms as chlorotic spots in variable intensity. Effect of ozone exposure on tomato crop plants was examined with respect to isoprene emission, growth and yield parameters. Enhancement in isoprene emission was observed from ozone exposed tomato plants as compared to unexposed plants. In exposed plants of early vegetative phase isoprene emission was 127% and 187% higher immediately after (within 1 hr) 75 ppb and 150 ppb ozone exposure respectively as compared to unexposed plants. Significant (p≤0.001) reduction in ozone exposed plants shoot length (2 to 10.5%), chlorophyll content (7 to 39%), carotenoids contents (5 to 42%), shoot biomass (upto 44%) and root biomass (8 to 65%) were observed as compared to unexposed plant. It was found that ozone exposure was more detrimental to LVP in comparison to FP and EVP. The results of the study also showed that 150 ppb of ozone exerted more harmful effects on the growth of different growth phases of tomato plants than 75 ppb ozone.
Sport and Social Deviations - a Prognostic Attitude
Authors: Kosiewicz Jerzy 
Published: July 2010

Sport and Social Deviations - a Prognostic AttitudeThe author focuses his attention first of all on social deviations which play a negative role in highly competitive sport. He tries to define - from the viewpoint of philosophy - how they will influence its future form.He proclaims that in philosophy there are at least two options:a. the one negating justifiability of philosophical statements on the future,b. the one affirming that justifiability - after Aurelius Augustine and Hegel.The author takes into account the second viewpoint and comes to the conclusion that as a philosopher (not a futurologist) he has the right to formulate hypothetical statements (referring to assumptions of the metaphysical hypothesis) on the influence of deviations on sport in the future.He pays attention first of all to increasing aggression - both in forms permitted and not permitted by the regulations - and the growing number of injuries among athletes. He maintains that both those injuries as well as phenomena connected with commercialization - such as reification, atomization and alienation (constituting reasons for possible disorders in the field of physical, mental and relational health) will contribute to worsening the image and deformation of sense and essence neither of sport as such, nor of particular sports. This also applies to corruption, poaching, fans' frustration and aggression, doping, alcoholism and nicotinism.He maintains also that social deviations coming from political, ideological, religious, racial and other similar factors will be less and less significant (admittedly they will not disappear, but their number and influence will be considerably limited).
The Penetration of Fundamentalistic Principles through Sport in Conditions of Globalization?
Authors: Oborný Josef 
Published: July 2010

The Penetration of Fundamentalistic Principles through Sport in Conditions of Globalization?The topic of this article unravels the dangers of penetration of fundamentalistic, political and ideological tendencies in the area of sport. It briefly analyzes the possibilities of sport abuse to realize the intention of some extremist groups. The infiltration of dangerous political attitudes to the sport is implemented through terrorism.
University Sports: Major Development and New Perspectives
Authors: Weiss Otmar 
Published: July 2010

University Sports: Major Development and New PerspectivesNew technologies, scientific findings and new or refined kinds of sport as well as national and international contests determine the image of university sports. There is no doubt that university sports are a growing area and will play an important role in the future. Their significance will increase in particular with the increase of knowledge about the positive effects of sports.Looking at social development as a whole and in its parts makes it possible to identify university sports in their present state, their dynamics and development within a context. By way of example major trends and prospects of university sports in contemporary societies will be discussed. In addition some data from empirical studies will be presented in order to underline the argumentation.
Characteristics of Admissions to a Recently Opened Psychiatric Emergency Care Centre
Authors: Brakoulias Vlasios , Mandali Rama , Seymour Joanne , Sammut Peter , Starcevic Vladan 
Published: July 2010

Objective: The Psychiatric Emergency Care Centre (PECC) is a relatively recent service development that aims to improve emergency care of psychiatric patients. The goal of this paper was to report on the characteristics of admissions to a recently established PECC. Method: Several key characteristics of admissions to the PECC were documented for each of 376 patients in the first 6 months of its operation. These characteristics were then compared to the characteristics of admissions of 299 patients in the ‘virtual’ PECC (a PECC within the general emergency department) in the 6 months prior to the opening of the PECC. Results: The most common presenting symptom in the PECC was suicidal ideation (47.6%, n = 179) and the most frequent diagnosis made in the PECC was adjustment disorder (35.9%, n = 135). When comparing admissions to the ‘virtual’ PECC, PECC admissions were characterized by a significantly less frequent use of physical restraint and haloperidol and midazolam as pro re nata (prn) medications. Conclusions: Although further study is needed, one possible advantage of the PECC may be a less frequent use of physical restraint and certain prn medications (i.e. haloperidol and midazolam) for agitated and aggressive patients.
Subverting the military normal
Authors: Schober Elisabeth 
Published: July 2010

Catherine Lutz, ed., The bases of empire: The Global Struggle against US Military Posts. New York: New York University Press, 2009, 356 pp., ISBN: 0-814-75244-6.Network of Concerned Anthropologists, The counter-counterinsurgency manual: Or, notes on demilitarizing American society. Chicago: Prickly Paradigm Press, 2009, 190 pp., ISBN: 0979405750.
Mycobacterium tuberculosis and TLR2 Agonists Inhibit Induction of Type I IFN and Class I MHC Antigen Cross Processing by TLR9
Authors: Simmons Daimon P. , Canaday David H. , Liu Yi , Li Qing , Huang Alex , Boom W. Henry , Harding Clifford V. 
Published: July 2010

Abstract
Dendritic cells (DCs) cross process exogenous Ags and present them by class I MHC (MHC-I) molecules to CD8+ T cells specific for Ags from viruses and bacteria such as Mycobacterium tuberculosis. Unmethylated CpG DNA signals through TLR9 to induce type I IFN (IFN-α/β), which enhances MHC-I Ag cross processing, but lipoproteins that signal through TLR2 do not induce IFN-α/β. In these studies we observed that M. tuberculosis, which expresses agonists of both TLR9 and TLR2, did not induce production of IFN-α/β or cross processing by murine DCs. Furthermore, M. tuberculosis and TLR2 agonists inhibited induction of IFN-α/β and DC cross processing by CpG DNA. Exogenous IFN-α/β effectively enhanced cross processing of M. bovis bacillus Calmette-Guérin expressing OVA, bypassing the inhibition of induction of endogenous IFN-α/β. In addition, inhibition of TLR9-induced cross processing of M. bovis bacillus Calmette-Guérin expressing OVA could be circumvented by pretreating cells with CpG DNA to induce IFN-α/β and MHC-I cross processing before inhibitory mycobacterial TLR2 agonists were present. Inhibition of the response to one TLR by another may affect the ultimate response to pathogens like M. tuberculosis that express agonists of multiple TLRs, including TLR2 and TLR9. This mechanism may contribute to immune evasion and explain why IFN-α/β provides little contribution to host immunity to M. tuberculosis. However, downregulation of certain TLR responses may benefit the host by preventing detrimental excessive inflammation that may occur in the presence of persistent infection.
MHC Class I Presentation and Regulation by IFN in Bony Fish Determined by Molecular Analysis of the Class I Locus in Grass Carp
Authors: Chen Weihong , Jia Zhenghu , Zhang Ting , Zhang Nianzhi , Lin Changyou , Gao Feng , Wang Li , Li Xiaoying , Jiang Yinan , Li Xin , Gao George F. , Xia Chun 
Published: July 2010

Abstract
Beyond their sequences, little is known regarding MHC class I presentation and regulation by IFN in bony fish. In this work, the class I locus (Ctid-UBA) was isolated from a grass carp fosmid library, and its polymorphisms and tissue expression were investigated. The Ctid-UBA and Ctid-β2–microglobulin genes then were expressed and refolded, and tetramer techniques were used to identify the CTL response. The interaction between grass carp type I IFN and Ctid-UBA genes was investigated. Two fosmids coding for Ctid-UBA *0101 and Ctid-UBA *0201 genes were sequenced. The SXY box and IFN-stimulated regulatory element motifs were located from the start codons to −800 bp in Ctid-UBA. A Southern blot showed three to four bands, suggesting that grass carp contains at least three class I loci. In addition, the Ctid-UBA allelic genes are expressed in all tissue of grass carp. The three-dimensional structure of Ctid-UBA *0102 showed that the peptide-binding domain was formed by the α1 and α2 domains, which could bind several nonapeptides of grass carp hemorrhagic virus. There were 1.60% more PE-positive cells in P1(QPNEAIRSL)-immunized fish than in blank and adjuvant control groups. Additionally, recombinant grass carp IFN could regulate the expression of Ctid-UBA. These results characterize the class I presentation, CTL response, and regulation by type I IFN in bony fish.
Multifunctional Au‐Coated TiO2 Nanotube Arrays as Recyclable SERS Substrates for Multifold Organic Pollutants Detection
Authors: Li Xuanhua , Chen Guangyu , Yang Liangbao , Jin Zhen , Liu Jinhuai 
Published: July 2010

AbstractA multifunctional Au‐coated TiO2 nanotube array is made via synthesis of a TiO2 nanotube array through a ZnO template, followed by deposition of Au particles onto the TiO2 surface using photocatalytic deposition and a hydrothermal method, respectively. Such arrays exhibit superior detection sensitivity with high reproducibility and stability. In addition, due to possessing stable catalytic properties, the arrays can clean themselves by photocatalytic degradation of target molecules adsorbed to the substrate under irradiation with UV light into inorganic small molecules using surface‐enhanced Raman spectroscopy (SERS) detection, so that recycling can be achieved. Finally, by detection of Rhodamine 6G (R6G) dye, herbicide 4‐chlorophenol (4‐CP), persistent organic pollutant (POP) dichlorophenoxyacetic acid (2,4‐D), and organophosphate pesticide methyl‐parathion (MP), the unique recyclable properties indicate a new route in eliminating the single‐use problem of traditional SERS substrates and show promising applications for detecting other organic pollutants.
Palladium/Tris(tert‐butyl)phosphine‐Catalyzed Suzuki Cross‐ Couplings in the Presence of Water
Authors: Lou Sha , Fu Gregory C. 
Published: July 2010

AbstractDipalladiumtris(dibenzylideneacetone)/tris(tert‐butyl)phosphonium tetrafluoroborate/potassium fluoride dihydrate [Pd2(dba)3/[HP(t‐Bu)3]BF4/KF⋅2 H2O] serves as a mild, robust, and user‐friendly method for the efficient Suzuki cross‐coupling of a diverse array of aryl and heteroaryl halides with aryl‐ and heteroarylboronic acids.
Characterization and electrical conductivity of poly(ethylene glycol)/polyacrylonitrile/multiwalled carbon nanotube composites
Authors: Aqeel Salem M. , Küçükyavuz Zuhal 
Published: July 2010

AbstractPolymer blends based on poly(ethylene glycol), polyacrylonitrile, and multiwalled carbon nanotubes (MWNTs) were prepared by the solvent cast technique from the dispersion of the MWNTs in the concentration range 0–3.45 wt %. The interaction of the MWNTs with the polymer blend was confirmed by a Fourier transform infrared (FTIR) spectroscopy study. The thermal properties of the polymer blend with the MWNTs were carried out by means of differential scanning calorimetry (DSC). It was evident from DSC that the polymer/MWNTs had a high thermal stability. Scanning electron microscopy was used to study the dispersion of the MWNTs in the polymer blend. To measure the electrical conductivity, the four‐point probe method was used. The electrical conductivity showed an ionic conductivity on the order of 4.4 × 10−4 to 1.2 × 10−2 S/cm. Relative changes in the conductivity with the concentration and temperatures for the samples were analyzed. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Miscibility study of poly(vinyl chloride)/poly(methyl methacrylate‐co‐4‐vinylpyridine) by viscosimetry, DSC, and FTIR
Authors: Benmerad Mouci Fethia , Djadoun Said , Alothman Zeid A. , Aouak Taieb 
Published: July 2010

AbstractThe miscibility of the poly(vinyl chloride)/poly(methylmethacrylate) system were improved by introducing pyridine units into poly(methylmethacrylate) main. For this purpose, we have synthesized through a radical polymerization a series of methylmethacrylate‐co‐vinyl‐4‐pyridine copolymers of different compositions and carried out a comparative study by viscosimetry, differential scanning calorimetry, and Fourier transform infrared spectroscopic (FTIR) methods. The viscosimetric analysis using the Krigbaum‐Wall, K. K. Chee, and Compos approaches revealed that, the Poly(vinyl chloride)/poly(methylmethactylate‐co‐4‐vinylpyridine)(PVC/MMA4VP‐15) at 15 wt % of 4‐vinylpyridine systems in tetrahydrofuran are completely miscible in all proportions. The differential scanning calorimetry analysis confirmed the miscibility of these systems in all proportions by the appearance of only one glass transition temperature between those of the two pure constituents. The Kwei and Schneider approaches showed also the miscibility of this system, which is due to the specific interactions between the acidic hydrogen atom of PVC and the nitrogen of MMA4VP‐15. The use of FTIR method has confirmed the occurrence of this kind of interactions by broadening and shifting of the involved functional groups vibration bands. In this work, we have also carried out a preliminary test of sorption of THF aqueous solution by PVC and PVC/MMA4VP‐15 blend membranes. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Effect of flyash content, particle size of flyash, and type of silane coupling agents on the properties of recycled poly(ethylene terephthalate)/flyash composites
Authors: Joseph Seena , Bambola V. A. , Sherhtukade V. V. , Mahanwar P. A. 
Published: July 2010

AbstractRecent time's polymer waste disposal is a challenging task as the quantity of polymer waste is increasing day by day. Here particulate composites have been developed from recycled poly(ethylene terephthalate) filled with flyash. Flyash of different particle sizes have been used, and effect of particle size and flyash content on the mechanical properties of composites has been analyzed. Tensile and flexural properties of the composites are found to increase with increase in filler content up to 15% and after that decreases due to the agglomeration of flyash particles. SEM studies also showed good dispersion at lower loadings. The use of silane coupling agents was found to increase the flyash/WPET interaction there by increase in mechanical properties is observed. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Fluorescence spectroscopy as a non invasive tool to follow in situ the polymerization in miniemulsion
Authors: Frochot Céline , Mascherin Marion , Haumont Amandine , Viriot Marie‐Laure , Marie Emmanuelle 
Published: July 2010

AbstractMiniemulsion polymerization is a powerful technique to produce a whole variety of latexes with controlled colloidal and chemical properties, which has gained an increasing importance in the past years. For many applications, the following of the kinetics of polymerization is of crucial importance. In this study, we developed a technique based on the use of fluorescent probes that could be a very promising noninvasive method to follow the reaction in situ. It was possible to follow qualitatively the kinetics of methyl methacrylate (MMA) polymerization by measuring the photophysical properties of fluorescent probes sensitive to the modification of the viscosity of the microenvironment along the reaction course. Two fluorescent sensors have been considered: 1,1‐dicyano‐4‐(4′‐dimethylaminophenyl)‐1,3‐butadiene) and pyrene. In this article, we will show that using these two different fluorescent probes allow the detection of MMA polymerization in miniemulsion. The results will be compared with a classical NMR method. This method could be easily adapted to different monomers. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011