bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute pancreatitis in children with inflammatory bowel disease: Risk factors, clinical course, and prognosis
Authors: Anafy Adi , Mirkin Yehoshua , Galai Tut , Ben‐Tov Amir , Moran‐Lev Hadar , Yerushalmy‐Feler Anat , Cohen Shlomi , Amir Achiya Z. 
Published: June 2024

AbstractObjectivesTo characterize the clinical course of acute pancreatitis (AP) in pediatric inflammatory bowel disease (IBD) patients compared to children with AP without IBD and to identify risk factors associated with AP among IBD patients.MethodsThis retrospective, single‐center study compared clinical characteristics of children (<19 years) with AP with and without concomitant IBD who were hospitalized 2005–2019. We also conducted a risk factor analysis of AP development in pediatric IBD.ResultsSixty‐eight (54% males) patients with 120 episodes of AP were admitted at a median age of 15.3 years. Thirteen patients (14 episodes) had a co‐diagnosis of IBD, representing 4% of our IBD patient population. The AP‐IBD patients presented with lower amylase levels compared to the non‐IBD patients (160 [interquartile range, IQR: 83–231] vs. 418 [IQR: 176–874] U/L, p > 0.01), all had a mild pancreatitis, and none required invasive intervention. The presumed etiology for AP in all IBD patients was IBD‐related: IBD flare‐up in five, side effects of medications in two, and undetermined in seven. The only risk factor for AP development among IBD patients was IBD‐associated arthritis (23% vs. 3% for IBD‐non‐AP, p = 0.04), while extracolonic Crohn's disease and induction therapy with nutrition were negative risk factors (15% vs. 51%, p = 0.05, and 8% vs. 44%, p = 0.04, respectively). Other parameters, including disease type and medications, were nonsignificant.ConclusionThe clinical course of AP in pediatric IBD patients is mild. Only IBD‐associated arthritis emerged as a risk factor for the development of AP, while, unexpectedly, IBD medication did not.
Maslinic acid alleviates alcoholic liver injury in mice and regulates intestinal microbiota via the gut–liver axis
Authors: Su Jingwen , Dai Yuan , Wu Xianyao , Zhou Xinhu , Fang Xianying , Ge Xiangyang , Zhao Linguo 
Published: June 2024

AbstractBACKGROUNDMaslinic acid (MA), a pentacyclic triterpene acid, is widely distributed in natural plants and mainly found in the fruit and leaves of olives and hawthorn. MA has been reported as having many health‐promoting functions, such as anticancer, anti‐inflammation and neuroprotective activities. According to previous study, hawthorn extract has certain hepatoprotective effects. However, the detailed mechanism is still unclear, especially the effect of MA on gut microbiota.RESULTSOur study reveals that MA effectively counteracts alcohol‐induced liver injury and oxidative stress. It mitigates alcohol‐induced intestinal barrier damage, reverses increased permeability and reduces translocation of lipopolysaccharide (LPS). This prevents LPS/Toll‐like receptor 4 activation, leading to decreased TNF‐α and IL‐1β production. Furthermore, MA rebalances gut microbiota by reversing harmful bacterial abundance and enhancing beneficial bacteria post‐alcohol consumption.CONCLUSIONMA, through modulation of gut microbiota, alleviates alcohol‐induced liver injury via the gut–liver axis. These findings support the potential use of MA as a functional food ingredient for preventing or treating alcoholic liver disease. © 2024 Society of Chemical Industry.
Color Duplex Ultrasonography for the Evaluation of Innominate, Subclavian, and Common Carotid Artery Stenosis
Authors: Zhang Jie , Wu Dianze , Wang Shaopeng , Bai Liyang , Meng Yan , Wang Lijuan 
Published: June 2024

ObjectiveThis study aimed to validate the efficiency of Doppler ultrasonography for predicting the innominate, subclavian, and common carotid artery stenosis.MethodsThis retrospective multicenter study between 2013 and 2022 enrolled 636 patients who underwent carotid Doppler ultrasonography and subsequent digital subtraction angiography. And 58 innominate artery stenosis, 147 common carotid artery stenosis, and 154 subclavian artery stenosis were included. The peak systolic velocity at innominate, subclavian, and common carotid artery, and velocity ratios of innominate artery to common carotid artery, innominate artery to subclavian artery, and common carotid artery to internal carotid artery were measured or calculated. The threshold values were determined using receiver operating characteristic analysis.ResultsThe threshold values of innominate artery stenosis were peak systolic velocity >206 cm/s (sensitivity: 82.8%; specificity: 91.4%) to predict ≥50% stenosis and >285 cm/s (sensitivity: 89.2%; specificity: 94.9%) to predict ≥70% stenosis. The threshold values of common carotid artery stenosis were peak systolic velocity >175 cm/s (sensitivity: 78.2%; specificity: 91.9%) to predict ≥50% stenosis and >255 cm/s (sensitivity: 87.1%; specificity: 87.2%) to predict ≥70% stenosis. The threshold values of subclavian artery stenosis were peak systolic velocity >200 cm/s (sensitivity: 68.2%; specificity: 84.4%) to predict ≥50% stenosis and >305 cm/s (sensitivity: 57.9%; specificity: 91.4%) to predict ≥70% stenosis.ConclusionsSymptomatic patients with ultrasonic parameters of velocity at innominate artery ≥206 cm/s, velocity at common carotid artery ≥175 cm/s, or velocity at subclavian artery ≥200 cm/s need to be considered for further verification and whether revascularization is necessary.
HMGB1 inhibition blocks ferroptosis and oxidative stress to ameliorate sepsis‐induced acute lung injury by activating the Nrf2 pathway
Authors: Jia Ya‐Jie , Xiong Sha , Yao Ming , Wei Yu , He Yan 
Published: June 2024

AbstractThe proinflammatory properties of high‐mobility group box protein 1 (HMGB1) in sepsis have been extensively studied. This study aimed to investigate the impact of HMGB1 on ferroptosis and its molecular mechanism in sepsis‐induced acute lung injury (ALI). A septic mouse model was established using the cecal ligation and puncture method. Blocking HMGB1 resulted in improved survival rates, reduced lung injury, decreased levels of ferroptosis markers (reactive oxygen species, malondialdehyde, and Fe2+), and enhanced antioxidant enzyme activities (superoxide dismutase and catalase) in septic mice. In addition, knockdown of HMGB1 reduced cellular permeability, ferroptosis markers, and raised antioxidant enzyme levels in lipopolysaccharide (LPS)‐stimulated MLE‐12 cells. Silencing of HMGB1 led to elevations in the expressions of ferroptosis core‐regulators in LPS‐treated MLE‐12 cells, such as solute carrier family 7 member 11 (SLC7A11), solute carrier family 3 member A2 (SLC3A2), and glutathione peroxidase 4. Furthermore, blocking HMGB1 did not alter ferroptosis, oxidative stress‐related changes, and permeability in LPS‐treated MLE‐12 cells that were pretreated with ferrostatin‐1 (a ferroptosis inhibitor). HMGB1 inhibition also led to elevated expressions of nuclear factor erythroid 2‐related factor 2 (Nrf2) and its downstream targets, heme oxygenase‐1 (HO‐1) and NAD(P)H: quinone oxidoreductase 1 (NQO1) in LPS‐treated MLE‐12 cells and lung tissues from septic mice. The Nrf2‐specific inhibitor ML385 reversed the effects of HMGB1 silencing on ferroptosis and cell permeability in LPS‐treated MLE‐12 cells. Our findings indicated that the inhibition of HMGB1 restrains ferroptosis and oxidative stress, thereby alleviating sepsis‐induced ALI through the activation of Nrf2 signaling.
Facile Modification of Propiolated Castor Oil via Nucleophilic Thiol‐Yne Click Reactions
Authors: Kalayci Damla , Akar Emre , Luleburgaz Serter , Çakmakçi Emrah , Gunay Ufuk Saim , Kumbaraci Volkan , Durmaz Hakan , Tunca Umit 
Published: June 2024

AbstractThe combination of modern click protocols and bio‐based building blocks is a great step toward energy‐efficient, and sustainable polymer production. Herein, thiol‐Michael addition (thiol‐yne) reactions from the toolbox of click chemistry protocols are chosen and propiolated castor oil (PCO) is used, a vegetable oil derivative, as the bio‐based building block for the facile functionalization of PCO with various thiols. In addition to the functionalization of PCO, hyperbranched and crosslinked polymers are also prepared. The thiol‐yne click functionalization reactions of the PCO are conducted at room temperature within 5 min and in the presence of an organic catalyst. The yields are found to change between 80% and 99% depending on the type of the thiol compound. The effect of various organic catalysts is investigated, and 1,8‐diazabicyclo(5.4.0)undec‐7‐ene (DBU) is found to be the most effective catalyst for the thiol‐yne modification reactions. The hyperbranched polymer reaches 23.8 kDa (Mw) within 5 min. The findings of this paper open up new horizons for polymer researchers who work in the field of sustainable polymers and click chemistry and the presented idea here is appealing because it offers a potential strategy for fast, reliable, modular, and functional macromolecule preparation from renewable vegetable oils.
What is to be expected? Optimizing the operationalization of consumer–brand relational norms
Authors: Makri Katerina , Bourdin David , Herz Marc 
Published: June 2024

AbstractConsumers relate to brands in ways analogous to how they relate with people. And, just as consumers have norms that guide their interpersonal relationships, they also have norms that guide their relationships with brands. While such relational norms are essential in determining brand value, extant literature offers no measure to effectively operationalize the framework that governs consumer–brand relationships. Preliminary work offers important insight but suffers from several methodological shortcomings, rendering subsequent empirical applications problematic and hindering theoretical and practical advancements. In seven studies (ntotal = 3121), we revisit seminal work on the consumer–brand relational norms construct to refine and validate its measurement. Our findings reveal a unidimensional set of items that display strong psychometric properties, offering a parsimonious measure that promotes consistent operationalizations of the construct across studies and enables comparison and integration of empirical results.
Optionally green: The effect of hybrid product default policy on consumer response to hybrid products
Authors: Usrey Bryan , Saridakis Charalampos , Theotokis Aristeidis 
Published: June 2024

AbstractIn today's marketplace, products can feature both “green” and “non‐green” attributes and consumers, with the press of a button, can select their preferred operating mode (green vs. nongreen). In this research, we define such products as hybrid, arguing that their choice architecture design—specifically, the default operational mode—plays a pivotal role in influencing consumer evaluation and purchase behavior. In four experiments, we found that consumers view a hybrid product as more environmentally friendly when the green mode is the default setting and can be turned off (opt‐out), rather than when the green mode must be activated (opt‐in). Specifically, we show that, when efficiency (vs. effectiveness)—related attributes are valued, the opt‐out (vs. opt‐in) default policy enhances purchase behavior. Moreover, we find that this effect is mediated by green attribute centrality, in that consumers perceive the opt‐out (vs. opt‐in) default policy as more central. Finally, we find that the effect of default policy is stronger for consumers with an analytical, as opposed to a holistic, thinking style. This article contributes to both default policy and hybrid product literature and provides managerial implications for the design and promotion of hybrid products.
Economic evaluation of barriers to minimize reservoir sport fish escapement
Authors: Lewis Madeline C. , Tyndall John C. , Dodd Ben , Weber Michael J. 
Published: June 2024

Abstract

Objective
Barriers can be an effective method for reducing escapement of reservoir sport fish; however, whether the financial benefits of a barrier outweigh the costs of a barrier is unknown. We sought to quantify the costs and benefits associated with constructing barriers to reduce fish escapement while explicitly accounting for variability and uncertainty.

Methods
We developed a framework using simulation modeling and discounted cash flow techniques to quantify the costs and benefits of barrier construction on Brushy Creek Lake, Iowa, where a barrier was constructed in 2020 to reduce escapement of stocked Walleye Sander vitreus and Muskellunge Esox masquinongy. We then incorporated this framework into an interactive Shiny application to enable cost–benefit evaluations across a wide range of barrier types, system types, species, and escapement rates.

Result
The present value of the parallel-bar barrier on Brushy Creek Lake, Iowa, over 10 years was US$69,576 (range = $64,484–$73,976), whereas the present value of escaped fish was $316,416 ($253,459–$378,823), indicating a net benefit of $246,840 ($188,975–$304,847) associated with barrier construction. The benefit–cost ratio of barrier construction was 4.55 after 10 years, indicating that for every $1 in present value spent on barrier construction, we saved $4.55 by preventing fish escapement. There was a 99% probability of a positive mean net benefit of the barrier after 3 years.

Conclusion
Our results indicate that barriers can be a cost-effective option to minimize fish escapement, and barrier costs are more predictable compared with the cost of escapement. Quantifying the value of escaped fish and barrier construction on an economic scale enables the use of formal decision-making tools to address complicated and multifaceted issues associated with reservoir fisheries management.
Domain decomposition methods and acceleration techniques for the phase field fracture staggered solver
Authors: Rannou Johann , Bovet Christophe 
Published: June 2024

AbstractThe phase field modeling of fracture is able to simulate the nucleation and the propagation of complex crack patterns. However, the relatively small internal lengths that are required usually lead to very fine meshes and high computational costs, especially for three‐dimensional applications. In the present work, additional cost also comes from the implicit dynamics regularization of unstable crack propagations which potentially leads to a large variation of time steps when switching from quasi‐static to dynamic regimes. To reduce the time to solution in this context, this study proposes a domain decomposition framework and acceleration techniques for the phase field fracture staggered solver. The displacement subproblem and the phase field one are solved with parallel domain decomposition solvers. Dual domain decomposition methods provide low cost preconditioner well adapted to the phase field subproblem. For displacement subproblems undergoing unstable crack propagations, primal domain decomposition methods are preferred to be less sensitive to the treatment of floating substructures. Preconditioners performances are assessed and scalability studies over academic test cases, up to 324 subdomains, are presented. Finally, the robustness of the approach is illustrated on two semi‐industrial simulations.
Cognitive changes in professional value and career development amid the COVID‐19 pandemic: A qualitative study of nurses' experiences
Authors: Luo Yawen , Li Quanlei , Ma Zhiqun , Hu Xiuying 
Published: June 2024

AbstractAimTo explore cognitions in nurses' professional value and career development amid the COVID‐19 pandemic and to analyse influencing factors.DesignA qualitative descriptive study design was employed.MethodsThirty practising nurses from three general hospitals in Chengdu, China, were purposively recruited. Face‐to‐face semi‐structured interviews were conducted. The content analysis was used for data analysis.ResultsAfter the outbreak of the COVID‐19 pandemic, there were obvious cognitive changes in nurses' professional value, including improvement in the cognition of professional value, awareness of the broadening of the field of acting professional value, and realization of increasingly high requirements in careers. Approval and gratitude of patients, social recognition and attention, self‐awareness of nurses were main influencing factors. For cognitive changes in career development, nurses became more motivated to develop their careers, had a clearer understanding of career development environment, and acquired a clearer understanding of what was needed to advance careers. Hospital support, social respect, family support, and team atmosphere were key influencing factors.ConclusionsThe contributions made by nurses in the prevention and control of the COVID‐19 pandemic have prompted positive changes in their cognition of professional value and career development. To promote nurses' positive understanding and approach to career development, measures should be taken by hospitals. Further, social respect, family support and team cooperation can enhance nurses' enthusiasm for career development.
Enhancing electric vehicle performance through buck‐boost converters with renewable energy integration using hybrid approach
Authors: Sakthivel A. , Ramesh S. , Das R. Mohan , Josh F. T. , Kumar U. Arun , Mohan B. S. 
Published: June 2024

AbstractThe electrification of vehicles has emerged as a pivotal technique for addressing environmental concerns and reducing reliance on conventional fuel sources. Conversely, the best way to incorporate renewable energy into electric vehicles (EVs) is still a challenging task, particularly in enhancing the performance of EVs through efficient energy management. The transition to EVs has gained momentum as part of global efforts to mitigate environmental impacts and reduce dependence on fossil fuels. This paper proposes a hybrid method for enhancing EV performance through buck‐boost converters with renewable energy integration. The proposed technique is the joined execution of Flying Foxes Optimization (FFO) and Viscoelastic Constitutive Artificial Neural Networks (vCANNs) techniques. The proposed method's goal is to enhance the energy efficiency, minimize EV charging cost, and mitigating environmental impacts. The renewable energy sources: solar panels, fuel cells, and wind turbines, are integrated into the EV power system through buck‐boost converters. The buck‐boost converter's control signal is optimized through the FFO method. vCANNs are used to predict these control parameters. The proposed strategy is executed in MATLAB software and is compared with existing strategies. In comparison with other current approaches like particle swarm optimization, heap based optimizer, and wild horse optimize, the proposed method achieves a high efficiency of 99% and low cost of 0.05 €/KWh.
Solvent‐free grafting route to develop thin and flexible polymer film from lignin
Authors: Saikia Ankumoni , Dutta Koushik , Singh Ajit 
Published: June 2024

AbstractThe recent advancements on the development of sustainable copolymers from lignin, has led us to explore a novel two‐step methodology for the development of lignin‐derived copolymers for flexible film preparation. In this work, firstly, chemical modification of lignin with itaconic acid (IA) in green solvent followed by grafting with lactic acid (LA) via solvent free polycondensation pathway was used to produce Lig‐g‐PLA copolymers. The effect of various reaction parameters like IA and LA amount, reaction time, solvent, temperature was studied to optimize yield of the reaction. Analytical techniques (FT‐IR, NMR, and XPS) confirmed successful chemical modification of lignin and copolymer (Lig‐g‐PLA) synthesis. The change in flexibility behavior of the polymer thin films (250 microns) prepared through hydraulic hot press method found to be dependent on the LA grafting. Notably, smooth surface of the films prepared with LA amount (IAL:LA 1:3 wt ratio) indicates enhanced compatibility between copolymer molecules due to the grafting of LA. Additionally, films prepared with a higher LA amount (i.e., IAL:LA 1:4 wt ratio) exhibited superior mechanical property with 3 times higher storage modulus as compared to the film prepared with lower LA amount (i.e., IAL:LA 1:2 wt ratio).
A highly sensitive electrochemical sensor based on surface molecularly imprinted polymers and graphene carbon nanotubes for highly selective detection of chlorpyrifos
Authors: Huang Yongqiang , Zhao Shan , Wang Qingqing , Xu Wanzhen , Huang Weihong 
Published: June 2024

AbstractPesticide residues represent a serious challenge for environmental protection, food safety, and public health. Addressing this challenge, this study strategically developed an electrochemical sensor with molecularly imprinted polymers (MIPs) as the recognition element to accurately detect chlorpyrifos in environmental samples. In this study, we used vinyl‐modified SiO2 as the matrix, methacrylic acid as the functional monomer, ethylene glycol dimethacrylate as the cross‐linker, and azobisisobutyronitrile as the initiator to synthesize the surface‐imprinted polymers. The development of the electrochemical sensor involved a detailed modification of the electrode, first by integrating carboxylated multi‐walled carbon nanotubes and graphene oxide to improve its properties, and then by applying a suspension of MIPs to the glassy carbon electrode. This process resulted in a sensor capable of detecting chlorpyrifos in environmental samples with high sensitivity. The electrochemical sensor, designed for chlorpyrifos detection, exhibited a robust linear response in peak current to varying concentrations of chlorpyrifos, ranging from 1 × 10−11 to 1 × 10−5 mol L−1. It achieved a detection limit as low as 1.85 × 10−11 mol L−1 (S/N = 3). Testing confirmed the sensor's exceptional repeatability, stability, and high selectivity towards chlorpyrifos, underscoring its efficacy. The demonstrated capabilities of this sensor suggest its substantial potential for widespread use in pesticide regulation and environmental conservation efforts.
Design of eco‐synthesized nanocomposites (PVA/TiO2) for promising agents in germicidal and photodecomposition behaviors
Authors: Vishnuvardhanraj G. , Vijayakumar S. , Muthukumaran R. , Vidhya E. , Wadaan Mohammad Ahmad , Mythili R. , Prathipkumar S. 
Published: June 2024

AbstractIn recent decades, there has been a significant surge in enthusiasm surrounding the topic of nanotechnology due to the rapid progress of innovation. The enhanced benefits exhibited by nanoparticles (NPs) in comparison to micro‐materials provide a diverse array of applications. Sustainable synthesis is a very efficient technique for producing nanomaterials using a simple, rapid, and eco‐friendly approach. In this investigation, titanium dioxide (TiO2) NPs were produced by combining the residue of coffee extract with PVA/TiO2 as an anchor material. The use of PVA/TiO2 substrates was employed to enhance the surface area of TiO2 NPs to enhance their characteristics. The TiO2 NPs/PVA nanocomposites (NCs) were characterized using procedures. The TiO2/PVA NCs exhibited an absorbance peak at 319 nm in the ultraviolet–visible spectrum, and the particle size was calculated to be 19.2 nm based on the data obtained from FE‐SEM and x‐ray diffraction analysis. Furthermore, an investigation was conducted to examine the photodecomposition and germicidal properties of the TiO2/PVA NCs. The TiO2/PVA NCs showed remarkable germicidal efficacy against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa. The investigation focused on examining the photodecomposition performance of the TiO2/PVA NCs in the presence of methylene blue (MB). The MB dye exhibited the greatest photocatalytic activity, reaching 89% within 70 min. Hence, the findings of this study indicate that the TiO2/PVA NCs have promising characteristics for use as both germicidal and photodecomposition properties.